bluuebunny/crossref_metadata_2025 huggingface dataset:
Pre-milling Effects on Self-propagating Reactions in Mechanochemical Synthesis of CdSe and ZnSe
Authors: Ohtani Tsukio , Kusano Yoshihiro , Ishimaru Kenta , Morimoto Takato , Togano Akihiro , Yoshioka Teppei
Published: September 2015

CdSe was synthesized from an elemental mixture via a mechanically-induced self-propagating reaction (MSR). No reaction was observed in the induction period. When each elemental powder was separately pre-milled for 15 min, the elemental mixture formed CdSe after 5 s of milling, which is much shorter than that for MSR without the pre-milling process. It was thus deduced, that in the induction period, the mechanical energy supplied by the ball-milling process was employed primarily for activation of the particles. ZnSe was also formed via MSR from a pre-milled elemental mixture after 5 s of milling. The pre-milled Zn and Se powders showed lattice expansion, suggesting that the strain energy accumulated in the particles.
Acid-regulated Electron-transfer Disproportionation of a Nonsubstituted Tetramethyl-biacridine Derivative
Authors: Yamamoto Koji , Nakamura Toshikazu , Higashibayashi Shuhei
Published: September 2015

A 9,9,9′,9′-tetramethyl-4,4′,10,10′-biacridine derivative without substituents at 2,2′,7,7′-positions was synthesized. The X-ray analysis revealed formation of one-dimensional stacked column in the crystal. The compound underwent electron-transfer disproportionation by acid stimulus. The generated cation radical exhibited high stability in CH2Cl2 solution under air at room temperature over 10 days even without bulky protecting substituents. By neutralization with NEt3, biacridine was recovered in high yield via back electron transfer.
Intergeneric hybridisation between Berula erecta and Helosciadium nodiflorum (Apiaceae)
Authors: Desjardins Stuart D. , Leslie Alan C. , Stace Clive A. , Schwarzacher Trude , Bailey John P.
Published: September 2015

A hybrid between Berula erecta and Helosciadium nodiflorum is reported from Chippenham Fen National Nature Reserve, Cambridgeshire, England. Parentage was investigated using chromosome counts, a maternally inherited chloroplast marker (rps16‐trnK), a biparentally inherited nuclear marker (ITS), and fluorescent in situ hybridisation (FISH) using labelled total genomic probes. Two parental genomes were identified in the putative hybrid (2n = 20), a maternal genome consisting of 9 chromosomes from B. erecta (2n = 18) and a paternal genome consisting of 11 chromosomes from H. nodiflorum (2n = 22). The implication of this hybrid for the taxonomy of the group is discussed, and a new hybrid genus is described: ×Beruladium (= Berula × Helosciadium). In overall appearance the hybrid resembles a small, creeping H. nodiflorum, and can be identified in the wild by a combination of characters: (1) the absence of a ring‐mark on the petiole below the lowest pair of leaflets that is characteristic of pure Berula, (2) lower leaves with up to five pairs of leaflets, (3) peduncles varying from shorter than to longer than rays, (4) umbels with several usually untoothed bracts, (5) a relatively long stigma and style, and (6) the absence of ripe fruits. The detection of this taxon is of considerable interest and, as far as we know, it is the first confirmed intergeneric hybrid in the Apiaceae within Europe.
Features of Modern Psycholinguistics Development and Communication in the Process of Teaching Foreign Languages and Cultures
Authors: Соколова  , Sokolova E.
Published: September 2015

The article devoted to the particular features of psycholinguistics and communication

process in modern tendencies of teaching foreign languages

and cultures.

The author provides the basic problems of psycholinguistics and emphasizes

the role of language and consciousness in solving professional communication

problems.
Verbal Means of Speech Influence in Local Encyclopedic Text
Authors: Яковлев  , Yakovlev D.
Published: September 2015

The article focuses on the analysis of verbal linguistic manipulation within

local encyclopaedic text relying on materials of local encyclopaedic texts

about Chelyabinsk.

The authors research considerable number of scientific works that use the

concept of verbal communication.

The major tasks are: defining the verbal communication concept, studying

main assets of speech influence, and analysing the bock of local encyclopaedic

texts to identify the means of persuasion and to form the list of

means of verbal influence within the local encyclopaedic text.
Past Master of Psychological and Pedagogical Methods Impact
Authors: Любезнова  , Lyubeznova N.
Published: September 2015

The article is devoted to the oratory of Franklin Delano Roosevelt. Roosevelt’s

speech had not only convincing, but also inspiring character. The

magical influence of his words due to the fact that he was the finest social

psychologist.
Scientists’ Communication at International Conferences
Authors: Брукс  , Bruks Elena
Published: September 2015

The author of the article tries to define specifics in communication in

English among professionals in natural sciences during international

functions, as well as to find the way to ease the problems in comprehension.
From the Experience of Training Russian As Foreign Language: Group and Individual Lessons for the Development of the Speech, with the Pupils, Having Different Level of Preparation
Authors: Салимова  , Salimova D. , Кудрявцева  , Kudryavtseva E.
Published: September 2015

The article deals with the peculiarities of teaching Russian as a foreign language

by teachers of the department, the main burden of whom is to work

in the Russian groups, the preparation of teachers of Russian language and

literature. Special conditions, namely uneven preparedness for the group of

trainees, different goals and intentions of the students, a variety of ethnic

composition – all this requires from specialists in Russian philology maximum

compression and concentrated types and forms of learning, different

both in structure and content. Only the most advanced and complex methods

causing interest in the subject, participation in the classroom at the

same time two or three teachers, attraction to participate in the classroom

as a teaching and Russian students give the opportunity to work effectively

in a group of foreign nationals. Maximum results and maximum impact can

be achieved only by the individual form of training (two or three teachers

and one trainee).
Encouraging Creative Speech Activity in Preschool Age
Authors: Дорошенко  , Doroshenko O.
Published: September 2015

The article considers the main stages of forming skills of creative narrative

(story-telling) in pre-school age children; are listed effective techniques to

stimulate creative preschoolers’ speech activity.
Media Competence As a Part of Students’ Language Competence
Authors: Ковригина  , Kovrigina A.
Published: September 2015

In this article we examine the notions of media competence and media critics,

which means a critical approach to mass media texts, from the point

of view of the needs of modern education not only for native speakers,

but also for students of foreign languages practicing with mass media material.

Special attention is paid to the question of students’ preparation to

real communication situations in Internet space. Strategies are proposed

for teachers to work with students in order to contribute to the development

of media competence.
Gender Aspect of Communication
Authors: Кошлякова  , Koshlyakova Mariya
Published: September 2015

Adherence to gender roles is an important aspect of business communication. When this marking professional roles according to principles of masculinity and femininity. It is argued that in business communication elements of the “female” model of speech behavior more relevant and appropriate in certain business situations.
Investment and interregional projects of tourism development in the regions
Authors: Цапук Дмитрий , Tsapuk Dmitriy
Published: September 2015

1. Александрова А. Ю. Новейшее представление о сфере туризма как системе // Современные проблемы сервиса и туризма. 2014. № 1. С. 24-38. 2. В Туле проходит презентация межрегионального туристского маршрута «Русские усадьбы». URL: http://mkrf.ru/press-tsentr/novosti/ministerstvo/v-tule-prokhodit-prezentatsiya-mezhregionalnogo-turistskogo-marshruta-russkie-us (Дата обращения: 09.07.2015). 3. Ганыиина Г. В. Особенности развития и сохранения народных художественных промыслов Центрального федерального округа // Современные проблемы сервиса и туризма. 2011. № 3. С. 78-84. 4. ДунецА. Н. Пространственная организация туризма в регионе: теоретические основы кластерного подхода // Современные проблемы сервиса и туризма. 2011. № 1. С. 37-44. 5. О состоянии туристской отрасли в регионах Центрального федерального округа: Доклад к заседанию Совета при полномочном представителе Президента Российской Федерации в Центральном федеральном округе. Ярославль: Правительство Ярославской области, 2012. 78 с.
Rural guesthouses as perspective direction of development of agritourism in the Ivanovo region
Authors: Яковенко Наталия , Yakovenko Nataliya
Published: September 2015

The prospect of tourism development in rural areas is connected with use of various approaches and models of the organization of agrotourism taking into account an environment and cultural and historical heritage of each region at steady observance of requirements of environmental protection, the quality standards and safety of tourists on vacation. Problems and perspectives of agrotourism development are caused by tendencies and changes in agriculture, problems of social and economic development of rural territories as in general in Russia, and in the Ivanovo region, directly. In this regard the Ivanovo region is the most interesting object for studying in Central Federal District because by the level of social and economic development it is the most crisis, depressive territory and takes the last place in relation to all regions of the district. In the territory of the district is represented a very wide range of attractive tourist recreational facilities and complexes which are popular both among Russian and foreign tourists. Experience of many European countries proves that in many Russian regions including the Ivanovo region possessing considerable ecological, recreational, social and cultural potential, development of agrotourism in rural areas can be the most effective instrument of their social and economic development. In recent years the Ivanovo region shows dynamic development of tourism, and offers unique tourist products. The biggest part of tourist resources of the region is located in rural areas. In article the characteristic of conditions for development of agrotourism in the region is given. Prospects of development of this type of tourism on the example of guesthouses are shown.
Experience of creation and functioning of tourist and information center in Russia: tourist and information center «Dmitrov» in Moscow region
Authors: Горбачева Ирина , Gorbacheva Irina , Феногенова Виктория , Fenogenova Viktoriya
Published: September 2015

The article deals with the problems of creation and functioning of Tourist and Information Center (TIC) in Russia as one of the most important segments of the hospitality industry. With the example of TIC «Moscow suburbs. DMITROV» the main problems that appear in process of creation and functioning of Russian TIC in current conditions are considered. The article presents basic features and capabilities of TIC, the range of services, examples of applications of citizens, the main difficulties in process of work. In addition, this article considers TIC not only as an organization that provides information to residents and visitors to the city, but also reflects their role as a bridge between business and municipal authorities in the territory for more effective their interaction and the formation of a competitive tourism product in the region. Big attention is paid to lack of normative legal acts defining and regulating the activities of TIC, their powers, which greatly complicates the process of work and the further development of such centers. To address these issues the integration of the work of all state and municipal bodies responsible for the development of tourism in the Russian Federation is required.

The article provides a brief analysis of creation and functioning of Tourist and Information Center «Moscow region. DMITROV», experience of its work and problems that have been encountered. It also contains proposals relating to the regulation of Tourist and Information Centers´ activities, defining their powers and duties as well as cooperation with each other and other organizations.
Barriers and facilitators to bicycle use in adults: a systematic review
Authors: Camargo Edina , Fermino Rogerio , Reis Rodrigo
Published: September 2015

The aim of this systematic review was to summarize the evidence on the barriers and facilitators to the use of bicycles in adults. Search terms were defined using Health Sciences Descriptors (DeCS) and Medical Subject Headings (MeSH) and evidence was searched in the following databases: Lilacs, SciELO, PubMed, Web of Science and Science Direct. A total of seven studies met the inclusion criteria and showed that the main barriers and facilitators to the use of bicycles are related to the physical, social and natural environment characteristics and individual characteristics (cognitive, psychological and emotional aspects). Interventions in the area of public health should consider these features to increase the use of bicycles in adults.
Características de vizinhança e prática de atividade física: uma revisão sistemática
Authors: Costa Miguel , Fonseca Maria , Silva Junior Sérgio , Vasconcelos Ana
Published: September 2015

O objetivo do estudo foi investigar a relação entre características de vizinhança e a prática de atividade Física em adultos, por meio de revisão sistemática. <span style="font-size: 12.0pt; font-family: ";Times New Roman";,serif; mso-fareast-font-family: ";Times New Roman";; mso-ansi-language: PT; mso-fareast-language: PT-BR; mso-bidi-language: AR-SA;" lang="PT">F<span style="font-size: 12.0pt; font-family: ";Times New Roman";,serif; mso-fareast-font-family: ";Times New Roman";; mso-ansi-language: PT; mso-fareast-language: PT-BR; mso-bidi-language: AR-SA;" lang="PT">oram utilizadas as bases de dados Scopus, Web of Science e Pubmed, acessadas em fevereiro de 2013, com os seguintes descritores ("Residence Characteristics"[Mesh] OR Neighborhood [all field]) AND ("Sedentary Lifestyle"[Mesh] OR Physical activity [all fields] OR Motor activity [Mesh]) na base Pubmed e nos demais sintaxes correspondentes. Na busca inicial, foram encontrados 5779 (sendo 2257 duplicatas). Após análise e aplicação de critérios de inclusão 19 artigos fizeram parte da revisão. O principal instrumento utilizado para mensurar a atividade física foi o IPAQ (16 artigos). Em relação aos questionários para mensurar percepção de vizinhança foram identificados 5 instrumentos diferentes. A análise da associação entre atividade física e características de vizinhança apontou diversas inconsistências. Independentemente do instrumento utilizado, ao analisar apenas o constructo de cada característica de vizinhança, os resultados dos estudos foram divergentes ou inconsistentes, não indicando ainda uma sólida relação entre as características de vizinhança e a prática de atividade física. A diversidade de populações e metodologias para mensuração de características de vizinhança podem ser um dos motivos das diferenças apontadas. Este estudo aponta uma lacuna importante nos estudos de associação entre a prática de atividade física e características de vizinhança. O não uso de análises multinível nos estudos analisados pode ser apontado como um motivo para as associações não significativas ou inconsistências encontradas entre os estudos.
Optimization of Industrial-Scale Assemble-to-Order Systems
Authors: van Jaarsveld Willem , Scheller-Wolf Alan
Published: September 2015

Using a novel stochastic programming (SP) formulation, we develop an algorithm for inventory control in industrial-size assemble-to-order (ATO) systems that has unparalleled efficiency and scalability. Applying our algorithm to several numerical examples, we generate new insights regarding the control and optimization of these systems.

We consider a continuous time model, seeking base-stock levels for components that minimize the sum of holding costs and product-specific backorder costs. Our initial focus is on first-come, first-served (FCFS) allocation of components to products; for this setting our algorithm quickly computes solutions for which the asymptotic optimality gap with the optimal FCFS base-stock policy is less than 1%. We then turn to two related questions: How do common heuristics used in practice compare to our performance, and how costly is the FCFS assumption?

For the first question, we investigate the effectiveness of ignoring simultaneous stock-outs (ISS), a heuristic that has been used by companies such as IBM and Dell. Our experiments indicate that ISS performance, when compared to the optimal FCFS base-stock policy, improves as the average newsvendor (NV) fractiles increase but suffers under lead-time demand correlations.

For the second question, we develop an efficiently computable upper bound on the benefit of optimal allocation over FCFS. We find that for many large ATO systems, FCFS performs surprisingly well and that its performance improves with decreasing NV fractile asymmetry among products and, again, with increasing average NV fractiles. We also investigate simple no-holdback allocation policies and find that they tend to outperform the best FCFS policies.
Integrated Bioenergy Supply Chain Network Planning Problem
Authors: Memişoğlu Gökhan , Üster Halit
Published: September 2015

We consider planning and design of an extended supply chain for bioenergy networks (i.e., networks for multibiomass as well as biofuel logistics) in an integrated fashion while simultaneously addressing strategic and tactical decisions pertaining to location, production, inventory, and distribution in a multiperiod planning horizon setting. In our modeling, we also explicitly incorporate realistic operational parameters, including biomass deterioration rates and transportation economies of scale. For an efficient solution of our model, we suggest a Benders decomposition–based algorithm that can handle realistic size problems for design and analysis purposes. We implement the approach in a particular way using callback functions, in which the master problem is solved only once; we also develop surrogate constraints for enhanced lower bounds to obtain improved convergence especially for large instances. We provide computational results that demonstrate the efficiency of the solution approach on a wide-ranging set of problem instances. Furthermore, we develop a realistic case using data pertaining to the state of Texas and conduct an extensive analysis on the effects of varying input parameters on the design outcomes for a bioenergy supply chain network.
Reliable Location-Routing Design Under Probabilistic Facility Disruptions
Authors: Xie Weijun , Ouyang Yanfeng , Wong Sze Chun
Published: September 2015

This study considers an integer programming formulation of a reliable location routing problem in which built facilities are subject to the risk of probabilistic disruptions. In this study we identify facility locations, and outbound delivery routing and backup plans during disruptions to minimize facility setup, routing, and customer penalty costs (if no delivery is possible). A variety of approaches (e.g., Lagrangian relaxation with embedded column generation and local search) to solving the problem are assessed. We conduct numerical case studies to test the performance of the proposed model and solution algorithms. The findings offer managerial insights into how various system parameters affect the optimal solution.
Becoming through a/r/tography, autobiography and stories in motion
Authors: LeBlanc Natalie , Davidson Sara Florence , Ryu Jee Yeon , Irwin Rita L.
Published: September 2015

The authors present stories in motion, reminding all those interested in practicebased research of the importance of a/r/tography as becoming-intensity, becoming-event and becoming-movement. Embracing a métissage approach, this article provides an example of art educators co-labouring in order to understand their need for materializing, theorizing and practising their ideas, and, in doing so, realize that being committed to emergence offers ways for becoming artist, researcher and teacher as ways of living one’s art practice as research.
Design students foreseeing the unforeseeable: Practicebased empathic research methods
Authors: McDonagh Deana
Published: September 2015

Designing for the future needs of people requires designers to develop an extensive research skill set and user-centred mindset. As our global community faces the unprecedented ageing tsunami, designers of tomorrow need to be prepared as effective design(er) researchers. Designers cannot rely upon a lengthy history of research methods to help shape our curricula, such as other more established disciplines, and this is both a challenge and an opportunity. As we prepare our students for positions and jobs that may not yet exist, we also have to prepare them for professional expectations that are still emerging. This article discusses a number of practice-based research methods and tools that are helping to contribute to the design student’s skill set whilst also shaping their mindset in terms of ageing, disability and emotional needs of users. In addition, practice-based research is shaping the way we teach, learn and connect with others beyond the classroom.
Nuclear Imaging in Dentistry -A novel modality to explore
Authors: Dathar Sahithi , Reddy Sudhakara , Koneru Jyothirmai , Preethi M , Guvvala Satheesh
Published: September 2015

Nuclear imaging is an exceptional branch of medical science that has been evolved in the latest decades in early diagnosis of a disease. The main underlying principle is that radioisotopes are injected in the body and emits gamma rays which are detected by special image receptors. Various nuclear imaging modalities include Scintigraphy, SPECT (Single photon emission computed tomography) and PET (Positron emission tomography) which can assess any functional changes that occur within a diseased cell. This article has essentially dealt with the fundamental principles of various nuclear imaging modalities and their applications in oral and maxillofacial region.
Effects of Emergent-Level Structure on Melodic Processing Difficulty
Authors: Russo Frank A. , Thompson William Forde , Cuddy Lola L.
Published: September 2015

Four experiments assessed the influence of emergent-level structure on melodic processing difficulty. Emergent-level structure was manipulated across experiments and defined with reference to the Implication-Realization model of melodic expectancy (Narmour, 1990, 1992, 2000). Two measures of melodic processing difficulty were used to assess the influence of emergent-level structure: serial-reconstruction and cohesion ratings. In the serial-reconstruction experiment (Experiment 1), reconstruction was more efficient for melodies with simple emergent-level structure. In the cohesion experiments (Experiments 2-4), ratings were higher for melodies with simple emergent-level structure, and the advantage was generally greater in the presence of simple surface-level structure. Results indicate that emergent-level structure as defined by the model can influence melodic processing difficulty.
BRAF V600E and decreased NIS and TPO expression are associated with aggressiveness of a subgroup of papillary thyroid microcarcinoma
Authors: Bastos André Uchimura , Oler Gisele , Nozima Bruno Heidi Nakano , Moysés Raquel Ajub , Cerutti Janete Maria
Published: September 2015

Background

Thyroid cancer incidence has dramatically increased worldwide over the last two decades. The rise is mostly due to an increased detection of small papillary thyroid carcinomas (PTCs) (≤20 mm), predominantly microPTC (≤10 mm). Although small tumors generally have an excellent outcome, a considerable percentage may have a more aggressive disease and worse prognosis. The clinical challenge is to preoperatively identify those tumors that are more likely to recur.

Aim

To improve risk stratification and patient management, we sought to determine the prognostic value of BRAF V600E,NRASorRET/PTCmutations in patients with PTC measuring <20 mm, mainly microPTC.

Methods

The prevalence ofRET/PTCfusion genes was examined by quantitative RT-PCR. BRAF V600E and NRAS Q61 mutations were determined by PCR sequencing. To further elucidate why some small PTC are less responsive to radioactive iodine treatment therapy, we explored if these genetic alterations may modulate the expression of iodine metabolism genes (NIS,TPO,TG,TSHRandPDS) and correlated with clinico-pathological findings that are predictors of recurrence.

Results

This study shows that tumors measuring ≤20 mm exhibited higher prevalence of BRAF V600E mutation, which correlated with aggressive histopathological parameters, higher risk of recurrence, and lower expression ofNISandTPO. Although this correlation was not found when microPTC were evaluated, we show that tumors measuring 7–10 mm, which were positive for BRAF mutation, presented more aggressive features and lower expression ofNISandTPO.

Conclusion

We believe that our findings will help to decide the realistic usefulness of BRAF V600E mutation as a preoperative marker of poor prognosis in small PTC, primarily in microPTC.
Effects of exercise dose on endogenous estrogens in postmenopausal women: a randomized trial
Authors: Friedenreich Christine M , Neilson Heather K , Wang Qinggang , Stanczyk Frank Z , Yasui Yutaka , Duha Aalo , MacLaughlin Sarah , Kallal Ciara , Forbes Cynthia C , Courneya Kerry S
Published: September 2015

Exercise dose comparison trials with biomarker outcomes can identify the amount of exercise required to reduce breast cancer risk and also strengthen the causal inference between physical activity and breast cancer. The Breast Cancer and Exercise Trial in Alberta (BETA) tested whether or not greater changes in estradiol (E2), estrone, and sex hormone-binding globulin (SHBG) concentrations can be achieved in postmenopausal women randomized to 12 months of HIGH (300 min/week) vs MODERATE (150 min/week) volumes of aerobic exercise. BETA included 400 inactive postmenopausal women aged 50–74 years with BMI of 22–40 kg/m2. Blood was drawn at baseline and 6 and 12 months. Adiposity, physical fitness, diet, and total physical activity were assessed at baseline and 12 months. Intention-to-treat analyses were performed using linear mixed models. At full prescription, women exercised more in the HIGH vs MODERATE group (median min/week (quartiles 1,3): 253 (157 289) vs 137 (111 150); P<0.0001). Twelve-month changes in estrogens and SHBG were <10% on average for both groups. No group differences were found for E2, estrone, SHBG or free E2 changes (treatment effect ratios (95% CI) from linear mixed models: 1.00 (0.96–1.06), 1.02 (0.98–1.05), 0.99 (0.96–1.02), 1.01 (0.95, 1.06), respectively, representing the HIGH:MODERATE ratio of geometric mean biomarker levels over 12 months; n=382). In per-protocol analyses, borderline significantly greater decreases in total and free E2 occurred in the HIGH group. Overall, no dose effect was observed for women randomized to 300 vs 150 min/week of moderate to vigorous intensity exercise who actually performed a median of 253 vs 137 min/week. For total and free E2, the lack of differential effect may be due to modest adherence in the higher dose group.
STAT4 contributes to adipose tissue inflammation and atherosclerosis
Authors: Dobrian A D , Hatcher M A , Brotman J J , Galkina E V , Taghavie-Moghadam P , Pei H , Haynes B A , Nadler J L
Published: September 2015

Adipose tissue (AT) inflammation is an emerging factor contributing to cardiovascular disease. STAT4 is a transcription factor expressed in adipocytes and in immune cells and contributes to AT inflammation and insulin resistance in obesity. The objective of this study was to determine the effect of STAT4 deficiency on visceral and peri-aortic AT inflammation in a model of atherosclerosis without obesity.Stat4−/−Apoe−/−mice andApoe−/−controls were kept either on chow or Western diet for 12 weeks. Visceral and peri-aortic AT were collected and analyzed for immune composition by flow cytometry and for cytokine/chemokine expression by real-time PCR.Stat4−/−Apoe−/−andApoe−/−mice had similar body weight, plasma glucose, and lipids. Western diet significantly increased macrophage, CD4+, CD8+, and NK cells in peri-aortic and visceral fat inApoe−/−mice. In contrast, inStat4−/−Apoe−/−mice, a Western diet failed to increase the percentage of immune cells infiltrating the AT. Also, IL12p40, TNFa, CCL5, CXCL10, and CX3CL1 were significantly reduced in the peri-aortic fat inStat4−/−Apoe−/−mice. Importantly,Stat4−/−Apoe−/−mice on a Western diet had significantly reduced plaque burden vsApoe−/−controls. In conclusion, STAT4 deletion reduces inflammation in peri-vascular and visceral AT and this may contribute via direct or indirect effects to reduced atheroma formation.
Teneligliptin improves metabolic abnormalities in a mouse model of postmenopausal obesity
Authors: Sameshima Azusa , Wada Tsutomu , Ito Tetsuo , Kashimura Ayaka , Sawakawa Kanae , Yonezawa Rika , Tsuneki Hiroshi , Ishii Yoko , Sasahara Masakiyo , Saito Shigeru , Sasaoka Toshiyasu
Published: September 2015

A decrease in serum estrogen levels in menopause is closely associated with the development of visceral obesity and the onset of type 2 diabetes in women. In the present study, we demonstrated the therapeutic effects of the novel DPP4 inhibitor, teneligliptin, on the features of postmenopausal obesity in mice. In the control group, female C57BL/6 mice were sham-operated and maintained on a standard diet. In the postmenopausal obese group, ovariectomized (OVX) mice were maintained on a high-fat diet, and were referred to as OVX-HF. In the treated group, teneligliptin at 60 mg/kg per day was administrated to OVX-HF, and were referred to as Tene. After a 12-week food challenge, the metabolic phenotypes of these mice were analyzed. Body weight, fat accumulation, and glucose intolerance were greater in OVX-HF than in control, while these abnormalities were markedly improved without alterations in calorie intake in Tene. Teneligliptin effectively ameliorated the characteristics of metabolic abnormalities associated with postmenopausal obesity. Regarding chronic inflammation in visceral adipose tissue, the numbers of F4/80+CD11c+CD206− M1-macrophages in flow cytometry, crown-like structure formation in immunohistochemistry, and proinflammatory cytokine expression were significantly attenuated in Tene. Hepatic steatosis was also markedly improved. Furthermore, decreased energy consumption in the dark and light phases, reduced locomotor activity in the dark phase, and lowered core body temperature in OVX-HF were ameliorated in Tene. Since obesity and reduced energy metabolism are a common physiology of menopause, teneligliptin appears to be beneficial as a treatment for type 2 diabetes in postmenopausal obesity.
Turbulent burning velocity in combustion chamber of SI engine fueled with compressed biogas
Authors: Ga Bui Van , Dong Nguyen Van , Hung Bui Van
Published: September 2015

Turbulent burning velocity is the most important parameter in analyzing pre-mixed combustion simulation of spark ignition engines. It depends on the laminar burning velocity and turbulence intensity in the combustion chamber. The first term can be predicted if one knows fuel composition, physico chemical properties of the fluid. The second term strongly depends on the geometry of the combustion chamber and fluid movement during the combustion process. One cannot suggest a general expression for different cases of engine. Thus, for accuracy modeling, one should determine turbulent burning velocity in the combustion chamber of each case of engine individually. In this study, the turbulent burning velocity is defined by a linear function of laminar burning velocity in which the proportional constant is defined as the turbulent burning velocity coefficient. This coefficient was obtained by analyzing the numerical simulation results and experimental data and this is applied to a concrete case of a Honda Wave motorcycle engine combustion chamber that fueled with compressed biogas. The results showed that the turbulent burning velocity coefficient in this case is around 1.3 when the average engine revolutions is in the range of 3000 rpm to 6000 rpm with biogas containing 80% Methane. We can then predict the effects of different parameters on the performance of the engine fueled with compressed biogas by simulation.
Transformational Leadership and Organizational Change: How do Leaders Approach Trauma-Informed Organizational Change…Twice?
Authors: Middleton Jennifer , Harvey Sarah , Esaki Nina
Published: September 2015

There is increasing interest in the human services field in transformational leadership (Fisher, 2009; Gellis, 2001; Mary, 2005) and the association between this style of leadership and employee engagement, thus impacting the quality of services delivered (Everett & Sitterding, 2011; Mary, 2005). The Sanctuary Model®, a trauma-informed organizational intervention, promotes many elements of the transformational style of leadership, especially the elements of inspiration, optimism, encouragement, honesty, motivation, respect, team-orientation, effective communications, empowerment, reliability, trustworthiness, and empathy (Bloom, 2005, 2011; Smith, 2011). This exploratory, qualitative study examines how social service agency leaders have used a transformational leadership approach to implement the model in two different organizations.
Rereporting to Child Protective Services among Initial Neglect Subtypes
Authors: Kang Jiyoung , Bae Hwa-Ok , Fuller Tamara
Published: September 2015

The current study aims to identify predictors of child maltreatment rereporting among initial neglect subtypes. The study used 16,707 investigated children in child protective services (CPS) of Illinois. A latent class analysis identified five neglect subtypes, using 11 indicators of alleged maltreatment type recorded by CPS agencies. A multivariate analysis showed that substantiation of the initial report and service receipt were common predictors of rereporting across all neglect subtypes; being Black, child age, parental relationship, and number of children increased the risk of rereporting for certain neglect subtypes. Regardless of the neglect subtype, cases with substantiation and service receipt required more effective interventions to reduce the risk of rereporting.
Balancing Work and Family: A Pilot Evaluation of an Evidence-Based Parenting Education Program
Authors: Baugh Eboni , Ballard Sharon M. , Tyndall Lisa , Littlewood Kerry , Nolan Melissa
Published: September 2015

In balancing family and work demands, there is an ever-increasing need for programming for working parents that increases their effectiveness in both domains. More evidence is needed in order to substantiate the delivery of such programs in the workplace. This study measured the effectiveness of an evidence-based parenting intervention, with pre- and postassessments of parenting experience, workplace outcomes, and child behavior. In all, 49 participants completed a 5-week pilot study of the adapted Level 3 Triple P – Positive Parenting Program. Participants reported increased positive parenting experiences and improved work engagement. Results provide evidence to support the delivery of short-term parenting interventions in the workplace, as well as evidence that these interventions can produce positive outcomes both at home and work.
Using Authentic Engagement to Improve Health Outcomes: Community Center Practices and Values (At the Agency)
Authors: Broeckling Jerica , Pinsoneault Laura , Dahlquist Amanda , Van Hoorn Maria
Published: September 2015

In this article, we explore how community centers seed healthy lifestyles through engagement of residents in community wellness initiatives in low-income, urban neighborhoods. These initiatives, focused on the building blocks of healthy lifestyles, include crossgeneration engagement in nutrition education, urban agriculture, access to healthy food, and physical activity. Success of these initiatives stems from the unique practices and values embedded in community centers: taking a holistic perspective on the individual, paying attention to the environment, cocreating with neighbors, partnering in purposeful ways, and focusing on resident- and community-centered outcomes. Through these practices and values, community centers are shaping initiatives that address the key underlying factors that affect health and creating long-term solutions that will benefit entire communities.
Microbial spectrum and microflora antibiotic sensitivity in patients with inflammatory eye diseases
Authors: Borovskikh Yelena Viktorovna , Borobova Inna Mikhaylovna , Yegorov Viktor Vasilyevich
Published: September 2015

The authors studied 1726 bacteriological cultures to find the etiology of inflammatory eye diseases, to assess the sensitivity of microorganisms to modern antibiotics used in ophthalmological practice. The main causative microorganisms are various Staphylococci, as a monoculture (85 %), or in association with other microorganisms (15 %). The microflora revealed is most sensitive to medications containing Tobramycin (87 %), Ofloxacin (72 %), Ciprofloxacin (71 %).
The dry eye syndrome in patients treated for breast cancer and methods to correct it
Authors: Kovalevskaya Mariya Aleksandrovna , Turovets Yekaterina Konstantinovna
Published: September 2015

Treatment for breast cancer in women promotes the dry eye syndrome and its worsening during chemo- and hormonotherapy courses, this fact being warranted by dry eye syndrome diagnostic tests. It is the authors’ opinion, that the dry eye syndrome treatment using a Cyclosporine A based medication in combination with artificial tears leads to considerable improvement. I case of inflammatory component overlay (redness, eye pain at ocular movements), such therapy is most effective. In all patients, the treatment was well tolerated, with positive dynamics noted. After a local treatment course, dry eye syndrome diagnostic tests’ results reached normal values.
Glaucoma and the dry eye syndrome
Authors: Brjesky Vladimir Vsevolodovich , Radukhan Mukhammed
Published: September 2015

The development of the dry eye syndrome in glaucoma patients is a pressing challenge during last 10 years. As reported by multiple investigators, the main causes for the development of corneal and conjunctival xerosis in such patients are: toxic action of preservatives in hypotensive ophthalmic medications, pharmacological effect of beta-blockers, and corneal trauma at the time of diagnostic manipulations. A meaningful action to prevent this disease is a to switch to either a preservative-free hypotensive ophthalmic medications, or to those containing a non-toxic preservative. A review of the literature was also done to find the causes, prevention and treatment methods of the dry eye syndrome in glaucoma patients
Some results of a glaucoma epidemiological study in 2011
Authors: Neroyev Vladimir Vladimirovich , Avdeyev Roman Vasilyevich , Kiseleva Olga Aleksandrovna , Bessmertnyy Aleksandr Markovich
Published: September 2015

The article provides data on general and primary glaucoma morbidity, the availability of modern diagnostic equipment in Federal districts of the Russian Federation. There is information from 82 regions of the country presented. The tables present the distribution of patients according to glaucoma stages. Indices are arranged into groups according to Federal districts
The evolution of surgical methods for treatment of benign ocular adnexa diseases
Authors: Onishchenko Yekaterina Sergeyevna , Novikov Sergey Aleksandrovich , Beldovskaya Nataliya Yuryevna , Zhabrunova Mariya Aleksandrovna
Published: September 2015

In the article, currently known methods of surgical treatment of inflammatory, degenerative and benign neoplastic diseases of ocular adnexa are reviewed. Special attention is paid by the authors to the advantages and shortcomings of various treatment methods. The newer treatment trends in this field are considered as well.
The experience of “Hyloparin” use in clinical practice
Authors: Tkachenko Natalya Viktorovna , Astakhov Sergey Yuryevich
Published: September 2015

The incidence of the “dry eye” syndrome diagnosis in developed countries increases from year to year. It is a reason for continuous scientific search for effective and safe methods for its treatment, for new ophthalmic medications. Because of the registration in the Russian Federation of “Hyloparin-Comod” containing heparin, our chair carried out a study on the efficacy of the medication in treatment of several eye diseases associated with the “dry eye” syndrome.
Ranibizumab and retinal photocoagulation in the treatment of ischemic retinal vein occlusion
Authors: Tultseva Svetlana Nikolaevna , Astakhov Yury Sergeevich , Nechiporenko Pavel Andreevich , Ovnanyan Andranik Yuraevich , Khatina Varvara Andreevna
Published: September 2015

Introduction. This investigation was focused on the post-RVO (retinal vein occlusion) macular edema treatment in cases with peripheral retinal ischemia, and on methods to estimate the ischemic area. Aim. To develop an examination and treatment algorithm for patients with chronic macular edema due to ischemic RVO. Material and methods. A prospective non-randomized study included 250 patients with RVO, the mean follow-up was 24.5 ± 6.5 months. Results. The drop-out of retinal capillary perfusion was detected in 175 patients (70 %). Peripheral ischemia was found in 125 cases, that is in 50% of all RVO patients and 71.4 % of all patients with ischemia. The mean number of ranibizumab injections performed after retinal photocoagulation was 2.9 ± 1.4. Patients treated with ranibizumab monotherapy for 24 months received 10.6 ± 2.5 intravitreal injections. Conclusions. The combination of ranibizumab intravitreal injections with retinal photocoagulation in the capillary non-perfusion areas can significantly reduce the number of injections and reduce the amount of neovascular complications.
An analysis of the economic impact of drug-coated balloon use for the treatment of peripheral artery disease
Authors: Micari Antonio , Vadalà Giuseppe , Corbo Mara , D'Alessandro Gianluigi , Castriota Fausto , Cremonesi Alberto
Published: September 2015

Background: Drug-coated balloons (DCBs) are an alternative for patients with peripheral arterial disease. Costs and re-intervention rates are potentially reduced compared to other technologies. We assessed the economic impact of these endovascular therapies.

Methods: An Italian National Healthcare Service-perspective budget impact model with a 5-year horizon was developed to compare relative costs of 4 index procedures (plain old balloon angioplasty (POBA), DCBs, and bare-metal and drug-eluting stents (BMSs, DESs)) based on 1-year repeat-procedure rates (target-lesion revascularization (TLR)). A published systematic review of TLR rates in patients with femoral-popliteal disease undergoing these treatments was used to measure effectiveness. Costs associated with each treatment were derived from diagnosis-related group tariffs. A decision analytic model was developed to estimate 1-year costs for index procedures and possible revascularizations.

 

Results: Pooled TLR rates show clear patient benefits for DCBs (6.9%) compared with POBA (21.6%) and BMSs (14.2%) and non-inferiority vs. DESs (7.3%). One-year payments for index and repeat interventions (by TLR rate) showed that DCBs were the least costly strategy, saving ~€1,000/patient vs. POBA. The potential savings were €8.7M, assuming 5% annual increase in DCB adoption over 5 years.

Conclusions: Despite initial higher investment, DCB represent a cost-saving alternative to other technologies. 
Progressive nature of heart failure and systems biology
Authors: Louridas George , Lourida Katerina
Published: September 2015

The progressive nature of heart failure (HF) is the predominant cause for the clinical course that the HF syndrome is taking. Systems biology methodology is of the utmost importance to explain and comprehend the build-in mechanisms of clinical adverse progression. Various heart diseases produce myocardial damage with subsequent left ventricular remodeling which is the principal underlying pathophysiological mechanism for the clinical progression of HF. The self-organized positive feedback stabilization mechanisms of left ventricular remodeling, adrenergic stimulation and activation of the renin-angiotensin-aldosterone system and natriuretic peptide systems, are hierarchical adaptive processes. These adaptive processes are responsible for further left ventricular remodeling with subsequent clinical deterioration and for the emergence of clinical phenotypes. These mechanisms are counteracted with angiotensin-converting enzyme inhibitors, angiotensin receptor blockers and β-blockers in an attempt to improve the adverse clinical phenomena of HF progression in a new but clinically worse stabilization level. In this review our intention is to underline the progressive nature of the HF syndrome and to demonstrate the significance of ventricular remodeling and the role of self-organized positive feedback adaptive processes.
A importância do Programa Sertão Empreendedor para a geração de renda na agricultura familiar
Authors: Ferreira J. S. , Martins D. S. S. , Oliveira J. S. , Alves S. V. , Nóbrega Andressa L.
Published: September 2015

A implementação do Programa Sertão Empreendedor no semiárido, destaca o grande avanço que a agricultura familiar vem conquistando no âmbito regional e suas contribuições para a fixação do sertanejo no campo. O trabalho em questão desenvolve uma análise das contribuições que o programa Sertão Empreendedor trará para o semiárido e para a sua população. Quanto à metodologia utilizada foi o de pesquisa bibliográfica. A análise dos resultados evidencia que a implementação desse programa no semiárido trará benefícios para a população como capacidade de geração e renda para os membros das comunidades rurais. É necessário que sejam desenvolvidos novos estudos com essa temática para que se tenha cada vez mais dados sobre a importância de políticas públicas para o desenvolvimento da agricultura e fixação do homem no campo.
Profitability and Risk Analysis of Soybean Planting Date by Maturity Group
Authors: Boyer Christopher N. , Stefanini Melissa , Larson James A. , Smith S. Aaron , Mengistu Alemu , Bellaloui Nacer
Published: September 2015

Limited knowledge exists regarding the yield response of soybean [Glycine max (L.) Merr.] from different maturity groups (MGs) to planting date in the southern United States. This information is needed to determine optimal planting dates for each MG. Our objective was to determine the optimum planting date for soybean in MG II, III, IV, and V in western Tennessee while considering producers’ risk preference. Net returns for each MG with four revenue protection (RP) insurance coverage levels were simulated using planting date–yield response functions for each MG. A multiyear experiment (2008–2010) was conducted on MG II, III, IV, and V planted at different dates in Milan, TN. The profit‐maximizing planting dates for soybean in western Tennessee were 24 May, 16 May, 13 May, and 22 May for MG II, III, IV, and V, respectively. The confidence intervals for the expected profit‐maximizing planting dates across MGs overlapped, suggesting that Tennessee producers have a long period for planting. Risk‐neutral to slightly risk‐averse producers would prefer MG III with no RP, but as the risk aversion increased, the preferred management strategy was MG III with 80% RP. These results will help producers determine optimum planting windows and crop insurance options for soybean production in West Tennessee based on their risk preferences.