bluuebunny/crossref_metadata_2025 huggingface dataset:
Optimization of the Enterprise Human Resource Management Information System Based on the Internet of Things
Authors: Li Haiqiu
Published: March 2021

In this paper, the optimization of the enterprise HR information system is studied based on IoT first‐off technology, the system demand phase is analysed, and the edge control system is designed and built. The hardware and software system and edge node management platform are implemented first, and then the communication scenarios between the edge layer of the system and the sensing layer, the edge layer, and the cloud layer are analysed, and the business type‐driven link selection algorithm and the northbound multilink switching algorithm are designed and implemented, respectively, to guarantee the communication reliability between different layers of the system. Based on the implementation of the above functions, the edge control system can meet the intelligence, expandability, and security requirements of IoT applications. An in‐depth investigation and research are launched mainly on the enterprise demand to determine the functional requirements and performance requirements of the enterprise and to achieve the basic logical structure; in the system design phase, the system architecture and other aspects of the design are realized. According to the conditions of the system function structure, a number of system module functions are designed in detail. The system is composed of the following modules, namely, personnel change management, organization management, and salary and benefits management. The system consists of the following modules, namely, personnel change management, organization management, compensation and benefits management, and personnel information management. The system modules run through the process of human resource management; in the system implementation stage, the system coding and page operation are realized based on the development tools and software development techniques. The system finally achieves the system design objectives and is put on a trial operation to meet its actual business requirements.
Network Pharmacological Study of Achyranthis bidentatae Radix Effect on Bone Trauma
Authors: Wu Liying , Hao Youguo , Dai Chuanqiang , Zhang Zhibang , Ijaz Munazza , Ibrahim Sobhy M. , Murtaza Ghulam , Yao Zhiguang
Published: March 2021

Purpose. Bone trauma is a clinical condition that afflicts the majority of the world’s population. For the management of bone trauma, the underlying mechanisms of the drugs effective for bone healing are deemed necessary. Achyranthis bidentatae Radix (ABR) is a popular alternative medicine recommended in the treatment of bone trauma and injury, yet its mechanism of action persists to be vague. This study was conducted for the evaluation of the mode of action of ABR through network pharmacology in treating bone trauma. Methods. An extensive survey of published works led to the development of a drug‐target database, after which multiple protein targets for bone trauma were discerned. The protein‐protein interaction network was developed by utilizing the STITCH database and gene ontology (GO) enrichment analysis using Cytoscape and ClueGO. Moreover, docking studies were performed for revealing the affinity of various ingredients with IL6. Results. The extensive literature survey yielded the presence of 176 components in ABR, and 151 potential targets were acquired. Scrutinization of these targets revealed that 21 potential targets were found to be associated with bone trauma. Out of which, some remarkable targets such as IL6, MAPK14, MAPK8, SRC, PTGS2, and MMP2 were observed to be associated in the functional interaction of ABR. According to docking results, several ingredients of ABR such as Baicalien, Copistine, Epiberberine, Kaempferol, and Palmatine have the lowest docking scores (range between ‐6 and ‐7). Conclusions. The results of the study elucidated that ABR can positively be utilized for the management of bone trauma, which can be mediated by multiple molecular mechanisms such as ERBB2 signaling pathway, positive regulation of oxidoreductase activity, JNK cascade pathway, multicellular organism metabolic process, T cell costimulation, and the positive regulation of MAPK activity. The findings also suggest that several ingredients of ABR such as Baicalien, Copistine, Epiberberine, Kaempferol, and Palmatine have good affinity with IL6, suggesting the promising potential of ABR in treating bone trauma, likely through IL6.
Immunomodulatory and Antioxidant Activities of Select Indonesian Vegetables, Herbs, and Spices on Human Lymphocytes
Authors: Safriani Novi , Rungkat Fransiska Zakaria , Yuliana Nancy Dewi , Prangdimurti Endang
Published: March 2021

Edible plants have attracted increasing attention as functional foods as they are rich in bioactive compounds with health benefits, including antioxidant and immunomodulatory activities. However, scientific evidence of these health effects is limited. This study is aimed at determining antioxidant and immunomodulatory activities of 25 select vegetables, herbs, and spices commonly consumed in Indonesia. Phytochemical profiles were determined by measuring total flavonoid content and 1H-NMR. Human blood lymphocyte cells were used to probe the immunomodulatory potency and treated with the methanol extract of these vegetables, herbs, and spices. The results showed the enhanced propensity for all tested plant extracts to stimulate lymphocyte proliferation, except Pandanus amaryllifolius. Etlingera elatior, Ocimum xcitriodorum, Kaempferia galanga, and Apium graveolens had the highest lymphocyte cell proliferation stimulation index (SI) at concentrations of 41.67, 16.67, 4.17, and 2.5 mg/mL culture, respectively (SI

2.21
±
0.05

,

2.62
±
0.12

,

3
±
0.05

, and

2.64
±
0.07

, respectively). The NMR spectra of these four most potent plants showed low peaks in the aromatic/phenolic area and several other peaks indicating the presence of terpenoid, steroid, amino acid, and sugar compounds. The results demonstrate the immunomodulatory potential of all vegetables, herbs, and spices, except P. amaryllifolius, although this potential did not necessarily correlate with flavonoid content and antioxidant activity. Nevertheless, this research showed promising health effect, particularly immunomodulation, of the various local plants. Further elaboration on the specific immunomodulatory activity will be interesting.
Electroacupuncture Inhibits Autophagy of Neuron Cells in Postherpetic Neuralgia by Increasing the Expression of miR‐223‐3p
Authors: Zou Jing , Dong Xueyang , Wang Ke , Shi Jing , Sun Ning
Published: March 2021

Postherpetic neuralgia (PHN) is a complication of herpes zoster viral infection. Its main manifestations are continuous or intermittent burning‐like and electroshock‐like pain in the affected nerves. Electroacupuncture (EA) is widely used in clinical treatment and exerts effects in alleviating neuropathic pain. In this study, we investigated the effect and underlying mechanism of EA on PHN. Sprague‐Dawley rats were treated with resiniferatoxin (RTX) to establish a PHN model and subjected to EA and/or miR‐223‐3p overexpression (OV) or interference. Mechanical withdrawal latency was measured as an indication of pain sensitivity. Hematoxylin‐eosin staining and transmission electron microscopy were performed to observe neuron cell morphology and autophagic vacuoles, respectively. ELISA was performed to detect reactive oxygen species (ROS) production and the levels of tumor necrosis factor‐ (TNF‐) α, inducible nitric oxide synthase (iNOS), interleukin‐ (IL‐) 6, and IL‐10. Changes in autophagy and apoptosis‐related miRNAs were detected by immunofluorescence and qRT‐PCR, respectively. In RTX‐treated rats, OV and EA reduced pain sensitivity, decreased the number of eosinophils, and increased that of nerve cells. ROS generation and the levels of TNF‐α and iNOS were significantly reduced, while those of IL‐6 and IL‐10 were increased. OV and EA induced fewer autophagic vacuoles than those in the model group. The expression of autophagy‐related protein microtubule‐associated protein 1 light chain 3‐II, ATG9, and Rab1 was decreased by OV and EA, whereas that of P62 was increased. qRT‐PCR revealed that miR‐223‐3p expression in the model group decreased but was increased by EA. EA inhibits neuron cell autophagy in PHN by increasing miR‐223‐3p expression.
Repositioning of the Severe Prolapsed Silicone Tubes after Bicanalicular Nasal Intubation: A Novel Technique
Authors: He Jinjing , Gong Jingwen , Zheng Qingqing , Jiang Jin
Published: March 2021

Background. Bicanalicular nasal intubation is widely used in lacrimal drainage system surgery. Its common complication is lateral displacement or spontaneous prolapse. When the distal part of the silicone tubes cannot be seen in the nose endoscopically, either repositioning or removal could be a challenge. We developed a simple technique to reposition the severe prolapsed silicone tubes. Method. This retrospective study included 6 patients with severe prolapsed silicone tubes who had undergone bicanalicular nasal intubation between January 2017 and December 2019. We used a memory wire probe to pull a nylon suture through the lacrimal passage retrograde. Then, the nylon suture was cut into two lines. One line was coiled to the prolapsed tube and tied to another line. This nylon turned into a “lasso” to capture the silicone tube and then lock its knot. By pulling the nylon suture, the severe prolapsed silicone tube was repositioned to the nasal cavity. Results. Using this technique, we successfully repositioned severe prolapsed silicone tubes without any complication in 6 cases. Conclusions. Silicone tube reposition guiding by using a memory wire probe is an optional technique in the treatment of prolapse of silicone tubes, particularly if the distal part of the silicon tube was embedded in the lacrimal sac and cannot be seen in the nose by endoscopy. It is a feasible, minimally invasive, safe, and effective method, avoiding premature tube removal.
A Novel COMP Mutated Allele Identified in a Chinese Family with Pseudoachondroplasia
Authors: Guo Bing-Bing , Jin Jie-Yuan , Yuan Zhuang-Zhuang , Zeng Lei , Xiang Rong
Published: March 2021

Pseudoachondroplasia (PSACH) is an autosomal dominant skeletal dysplasia with an estimated incidence of ~1/60000 that is characterized by disproportionate short stature, brachydactyly, joint laxity, and early‐onset osteoarthritis. COMP encodes the cartilage oligomeric matrix protein, which is expressed predominantly in the extracellular matrix (ECM) surrounding the cells that make up cartilage, ligaments, and tendons. Mutations in COMP are known to give rise to PSACH. In this study, we identified a novel nucleotide mutation (NM_000095.2: c.1317C>G, p.D439E) in COMP responsible for PSACH in a Chinese family by employing whole‐exome sequencing (WES) and built the structure model of the mutant protein to clarify its pathogenicity. The novel mutation cosegregated with the affected individuals. Our study expands the spectrum of COMP mutations and further provides additional genetic testing information for other PSACH patients.
Influence of Deformation and Instability of Borehole on Gas Extraction in Deep Mining Soft Coal Seam
Authors: Zhang Xue-Bo , Shen Shuai-Shuai , Feng Xiao-Jun , Ming Yang , Liu Jia-jia
Published: March 2021

To study the effects of the three deformation instability modes of gas drainage borehole on gas drainage, the deformation instability mechanism of soft coal seams is analyzed, three deformation instability modes are proposed for soft coal seams, namely, complete holes, collapse holes, and plug holes, and a solid‐fluid coupling model incorporating dynamic change of borehole suction pressure is established. The results of the study show the following. (1) When there is no borehole deformation (i.e., complete borehole), the suction pressure loss of drainage system in the borehole is very small, whose effect on gas drainage can be neglected. (2) In case of borehole collapse, the suction pressure loss is big at the collapse segment, and the total suction pressure loss of the drainage system in the borehole is bigger than that in the complete hole. However, it is smaller than the suction pressure of the drainage system and exerts limited effect on gas drainage. As the borehole collapse deteriorates, the effective drainage section of the borehole becomes smaller, while the suction pressure loss in the borehole increases continuously; thus, the gas drainage effect continuously worsens. (3) In case of plug hole, a continuous medium forms between the plug segment coal body and the surrounding coal seam, the plug segment drainage pressure turns into coal‐bed gas pressure, and effective drainage length of the borehole shortens, seriously affecting the gas drainage effect. The study carries important theoretical guiding significance for improving gas drainage effect and effectively preventing gas disasters.
Clinical and Translational Considerations for Understanding Depression and Anxiety in Patients with Inflammatory Bowel Disease
Authors: Sidebottom Ashley M. , Rodriguez Tina G. , Karpin Jordan E. , Rubin David T.
Published: March 2021

Depression and anxiety are comorbidities of inflammatory bowel disease (IBD). Though previous studies have proposed a relationship between anxiety, depression, and IBD, causality and directionality are largely unknown. Current and future research in these areas is aimed at exploring the biological underpinnings of this relationship, specifically pertaining to small molecule metabolism, such as tryptophan. Tryptophan is acquired through the diet and is the precursor to several vital bioactive metabolites including the hormone melatonin, the neurotransmitter serotonin, and vitamin B3. In this review, we discuss previous findings relating mental health comorbidities with IBD and underline ongoing research of tryptophan catabolite analysis.
Improvement of Experimental Equipment Based on the One‐Step Outflow Test and Research on Rapid Determining SWCC
Authors: Wu Jiaqi , Li Huan , Wang Anming , Huang Zhiquan
Published: March 2021

The soil‐water characteristic curve (SWCC) is an important hydraulic parameter for modeling water flow and contaminant transport in the unsaturated soil. However, direct measurement of the SWCC is still difficult. The commonly used measuring instrument in the laboratory is the pressure plate extractor. In this paper, the original pressure plate extractor has been improved based on the one‐step outflow test. Compared with the original pressure plate extractor, three devices, water storage, data acquisition system, and bubbles scouring device, are added to the improved pressure plate extractor. The improved equipment eliminates the problems of long test time consumption and inaccurate test data. A one‐step outflow test is performed utilizing the improved pressure plate extractor. The test data (the amount of spilled water and the time of pressurization) are substituted into the one‐dimensional moisture migration analysis software HYDRUS‐1D. The parameters (α, m, and n) are identified by the numerical inversion method in the inversion module of the HYDRUS‐1D, which are associated with the VG model to fit SWCC. The fitted SWCC is highly consistent with the measured SWCC, which is obtained from the conventional test of the original pressure plate extractor. Results confirm that the improved pressure plate extractor not only saves considerable time but also effectively measures the SWCC. The improved pressure plate extractor also involves a simple operation. The influence factors of controlling the geometry of SWCC are also discussed, the results of the discussion confirm that the geometry of SWCC is directly controlled by pore distribution, and the consolidation pressure is an indirect factor.
Effect of COVID-19 on Mortality of Pregnant and Postpartum Women: A Systematic Review and Meta-Analysis
Authors: Karimi Leila , Makvandi Somayeh , Vahedian-Azimi Amir , Sathyapalan Thozhukat , Sahebkar Amirhossein
Published: March 2021

Background. Based on what is known at this time, pregnant women are at an increased risk of severe illness from COVID-19 compared to nonpregnant women. Additionally, pregnant women with COVID-19 might have an increased risk of adverse pregnancy outcomes. To investigate the effects of coronavirus disease 2019 (COVID-19) on mortality of pregnant and postpartum women, we performed a systematic review of available published literature on pregnancies affected by COVID-19. Methods. Web of Science, SCOPUS, and MEDLINE- databases were searched for original studies concerning the effect of COVID-19 on mortality of pregnant and postpartum women published by July 10, 2020. Meta-analyses of proportions were used to combine data and report pooled proportions. Results. 117 studies with a total of 11758 pregnant women were included. The age ranged between 15 and 48 years. Most subjects were infected with SARS-CoV-2 in the third trimester. Disease severity was not reported in 1125 subjects. Maternal mortality was 1.3%. In 100% of fatal cases with adequate data, fever alone or with cough was one of the presenting symptoms. Also, dyspnea (58.3%) and myalgia (50%) were the most common symptoms. Sore throat (8.3%) and gastrointestinal symptoms (anorexia, nausea) (8.3%) were rare. The rate of comorbidities was 20% among COVID-19 deaths. The majority of COVID-19-infected women who died had cesarean section (58.3%), 25% had a vaginal delivery, and 16.7% of patients were not full term. Conclusion. COVID-19 infection in pregnant women was associated with higher rates (and pooled proportions) of cesarean section and mortality. Because new data are continuously being generated and published, the findings of this study can be complete and updated with new researches. The results of this study can guide and improve prenatal counseling of COVID-19-infected pregnant women.
CRISPR-Mediated Kinome Editing Prioritizes a Synergistic Combination Therapy for FGFR1-Amplified Lung Cancer
Authors: Yang Zhang , Liang Shun-Qing , Yang Haitang , Xu Duo , Bruggmann Rémy , Gao Yanyun , Deng Haibin , Berezowska Sabina , Hall Sean R.R. , Marti Thomas M. , Kocher Gregor J. , Zhou Qinghua , Schmid Ralph A. , Peng Ren-Wang
Published: March 2021

Oncogenic activation of the FGFR pathway is frequent in lung and other cancers. However, due to drug resistance, pharmacological blockage of aberrant FGFR signaling has provided little clinical benefit in patients with FGFR-amplified tumors. The determining factors for the limited efficacy of FGFR-targeted therapy remain incompletely understood. In this study, we performed kinome-wide CRISPR/Cas9 loss-of-function screens in FGFR1-amplified lung cancer cells treated with an FGFR inhibitor. These screens identified PLK1 as a potent synthetic lethal target that mediates a resistance mechanism by overriding DNA damage and cell-cycle arrest upon FGFR1 inhibition. Genetic and pharmacological antagonism of PLK1 in combination with FGFR inhibitor therapy synergized to enhance antiproliferative effects and drove cancer cell death in vitro and in vivo through activation of the γH2AX–CHK–E2F1 axis. These findings suggest a previously unappreciated role for PLK1 in modulating FGFR1 inhibitor sensitivity and demonstrate a synergistic drug combination for treating FGFR1-amplified lung cancer.

Significance:

The identification of PLK1 as a potent synthetic lethal target for FGFR-targeted therapy provides an innovative rationale for the treatment of lung and other FGFR1-amplified cancers.
Design and simulation of high-swing fully differential telescopic Op-Amp
Authors: Pezeshki Zahra
Published: March 2021

This article describes the process of design and simulation of a high-swing fully differential telescopic Operational Amplifier (Op-Amp). Due to the Common Gate-Common Source (CG and CS) cascode structure, the gain is very high. To maximize this gain, the load must also be selected such as two current sources. This circuit has the higher voltage in output than current Op-Amps in accordance with desirable characteristics. The loss of power of this operating amplifier are very low and in milliwatts. With use of a power supply of 1.8 V, it achieves a high-swing 1.2 V, a differential gain of 76.333 dB, ω_uGB of 412 MHz, and 50 dB CMRR. This new design through the simulations and analytically shows that the high-swing fully differential telescopic Op-Amp retains its high CMRR even at high frequencies.
Numerical approach for extraction of photovoltaic generator single-diode model parameters
Authors: Benahmida Abdelaaziz , Maouhoub Noureddine , Sahsah Hassan
Published: March 2021

In this work, a numerical approach has been proposed to estimate the five single-diode circuit model physical parameters of photovoltaic generators from their experimental current-voltage characteristics. Linear least square method has been used to solve the system of three linear equations to express the shunt resistance, the saturation current and the photocurrent as a function of the series resistance and the ideality factor. Two key points have been used to solve the system of two nonlinear equations to extract values of series resistance and ideality factor. The advantage of the proposed method with respect of existing numerical techniques is that use only two key points of the experimental characteristic and need only two initial guesses and does not use any approximation. To evaluate the proposed method, three PV generators data have been used to compare the experimental and the theoretical curves. The application of the proposed method provides a good agreement with the experimental.
Satellite image inpainting with deep generative adversarial neural networks
Authors: Zaytar Mohamed Akram , El Amrani Chaker
Published: March 2021

This work addresses the problem of recovering lost or damaged satellite image pixels (gaps) caused by sensor processing errors or by natural phenomena like cloud presence. Such errors decrease our ability to monitor regions of interest and significantly increase the average revisit time for all satellites. This paper presents a novel neural system based on conditional deep generative adversarial networks (cGAN) optimized to fill satellite imagery gaps using surrounding pixel values and static high-resolution visual priors. Experimental results show that the proposed system outperforms traditional and neural network baselines. It achieves a normalized least absolute deviations error of (  &  decrease in error compared with the two baselines) and a mean squared error loss of  (  &  decrease in error) over the test set. The model can be deployed within a remote sensing data pipeline to reconstruct missing pixel measurements for near-real-time monitoring and inference purposes, thus empowering policymakers and users to make environmentally informed decisions.
Analysis of spammers’ behavior on a live streaming chat
Authors: Yousukkee Sawita , Wisitpongphan Nawaporn
Published: March 2021

Live streaming is becoming a popular channel for advertising and marketing. An advertising company can use this feature to broadcast and reach a large number of customers. YouTube is one of the streaming media with an extreme growth rate and a large number of viewers. Thus, it has become a primary target of spammers and attackers. Understanding the behavior of users on live chat may reduce the moderator’s time in identifying and preventing spammers from disturbing other users. In this paper, we analyzed YouTube live streaming comments in order to understand spammers’ behavior. Seven user’s behavior features and message characteristic features were comprehensively analyzed. According to our findings, features that performed best in terms of run time and classification efficiency is the relevant score together with the time spent in live chat and the number of messages per user. The accuracy is as high as 66.22 percent. In addition, the most suitable technique for real-time classification is a decision tree.
Recent development of smart traffic lights
Authors: Aulia Yusuf A’isya Nur , Setyo Arifin Ajib , Yuli Zulkifli Fitri
Published: March 2021

Increased traffic flow causes congestion, especially in large cities. Even though congestion is not unusual, traffic jams still result in very high economic and social losses. Several factors cause congestion, one of which is traffic lights. Therefore, a mechanism is needed so that traffic lights can intelligently and adaptively manage signal time allocation according to traffic flow conditions. A traffic light with this type of mechanism is known as a smart traffic light. Smart traffic light cycle settings can be grouped based on the traffic density, scenarios for emergency vehicles, and the interests of pedestrians. This paper analyzes the methods and technologies used in the development of smart traffic light technology from the perspective of these three situations as well as the development of smart traffic light technology in the future.
Teachers’ views on challenges affecting learners’ performance in natural science
Authors: Ndjangala M.N.N. , Abah J. , Mashebe P.
Published: March 2021

In Namibia, natural science (NS) is one of the priority subjects in upper primary phases (Grades 4 to 7). However, in the Omusati Region of Namibia, there are increasing public concerns that many learners are not performing well in NS. Thus, this study surveyed the views of NS teachers on the challenges affecting upper primary learners’ performance in NS at three selected combined schools in the Omusati Region. Qualitative research design using face-to-face interview was used to gather the views of upper primary NS teachers in the schools. Seven teachers who are currently teaching NS at the selected schools were selected using the purposive sampling method to participate in the study. The results obtained revealed that the following challenges affect upper primary learners’ performance in NS in the selected schools: medium of instruction, lack of adequate teaching and learning resources, lack of laboratories, sensitive topics, overcrowded classroom, indiscipline among learners, absenteeism, unfavorable teaching environment, hunger, and lack of proper guidance from subject advisory teachers. The study recommended that the government should provide schools with feeding programs, build laboratories, renovate classes and provide teaching materials. The schools should evolve disciplinary measures to check the learners’ indiscipline.
Undergraduates entrepreneurial intention: Holistic determinants matter
Authors: Owee Kowang Tan , Abdulah Apandi Siti Zulaiha Binti , Choon Hee Ong , Chin Fei Goh , Saadon Mohd Saiful Izwaan , Othman Mohamad Rosni
Published: March 2021

The role of entrepreneurship in job creation and unemployment reduction is well established by prior studies. Hence, one of the ways to address the unemployment issue among young graduates in Malaysia is to explore how entrepreneurial intention could be embraced into the broader context of the country's education system. Empirical research found that prior studies on entrepreneurship education in Malaysia tends to focus on reviewing educational policies, issue and challenges. The concept of the entrepreneurial intention determinants beyond entrepreneurial education remains ambiguous. Hence, this study advances the discussion in entrepreneurship education by reviewing determinants for entrepreneurial intention from holistic perspective by integrating Model of Personality Traits and the theory of planned behavior (TPB). Five determinants for entrepreneurial intention are identified from literature review, which are entrepreneurship attitude, subjective norm, behavior control, entrepreneurship education and personality traits. The study is quantitative based, 360 questionnaires were distributed to the undergraduates from three faculties of a public university in Malaysia, with 199 responded. Data was analyzed via Pearson correlation and ANOVA analysis. Finding from the study suggested all the five entrepreneurial determinants are significantly correlated with entrepreneurial intention, and there is no significant difference on entrepreneurial intention based on faculty. However, one of the remarkable finding is Entrepreneurship Education is viewed as determinant with the lowest correlation coefficient with entrepreneurial intention. The implication of this finding is perhaps the content of entrepreneurial education shall emphasize on cultivating students’ entrepreneurial attitude, behavioral and personality rather than the theoretical part of entrepreneurial and entrepreneurship.
An investigation of teacher and teacher candidates’ views on the course of school experience
Authors: Akkuş Emine Begüm , Üredi Lütfi
Published: March 2021

One of the most important elements involved in the development of countries is teachers. Therefore, developing countries should pay attention to training good teachers. Thus, the purpose of this study was to present the opinions of teachers and prospective teachers on the “teaching experience” course. The study is based on a qualitative research. The data were collected from 84 teachers in Şanlıurfa, an eastern city of Turkey and 88 prospective teachers (undergraduate seniors) studying at Mersin University, Turkey. Semi-structured interview form was utilized to collect the required data. Besides, content analysis was applied in the study. The data have been expressed in numbers. Results have displayed that there are problems arising from the stakeholders in the “teaching experience” lesson. The types of schools attending internships are not inclusive. Not all stakeholders are working cooperatively. Moreover, the following suggestions were accordingly put forward: 1) The internship duration can be extended; 2) Applications covering all types of schools should be added; and 3) Stakeholders should be encouraged to work in a collaborative way.
Performance enhancement of relays used for next generation wireless communication networks
Authors: Prasad Padhy Saraju , Panda Madhusmita , Sethi Srinivas , Tripathy Aruna
Published: March 2021

Relaying is one of the latest communication technologies developed for wireless networks like WiMAX, LTE Advanced and 5G Ultra Reliable Low Latency Communication (URLLC) networks to provide coverage extension as well as higher bitrates for cell edge users. Thus they are included in the design of next generation wireless communication systems to provide performance improvement in terms of coverage and capacity over their predecessors. Other promising features of this technology include easy to implement and reduction in deployment cost. The objective of this paper is to analyze both cooperative and non-cooperative relaying techniques in the Infinite Block length regime and findout the benefits of Relay implementation. A single Amplify and Forward (A&F) Relay is used for this purpose. Reduction in power requirement for Simple Relay is shown in comparison to the direct transmission, using experimental analysis with Matlab simulation. SER (Symbol error rate) is calculated at the receiver for no relay, simple Relay and Cooperative Relaying scenario to show the improvements of cooperative Relaying implementation.The performance enhancement of the Relay is then carried out using Particle Swam Optimization (PSO) optimization technique where allocation of power between Base station and Relay Node is effectively distributed for optimum performance.
Expectation of administering the first aid for traumatic victims during the absence of pre-hospital service
Authors: Anita Fitri , Hariyanti Tita , Suharsono Tony
Published: March 2021

Traffic incidents become typical cases of trauma outside of hospitals. The integrated-emergency nursing system outside of hospitals becomes an important component to minimize any worsening condition of the traumatic victims. However, this pre-hospitalized service system has not been formally established in several cities or municipalities. This research aims to explore various hopes of the trauma-victim aid process in a region that has not applied pre-hospitalized emergency service formally. This research was carried out by implementing a qualitative research method and a case study approach to identify the themes. The research was conducted in Konawe municipality, from February until March 2020. It was done by interviewing eight participants consisting of the citizens, traffic police officers, hospital party, and health agency. Four themes result from this research. Establishing the pre-hospitalized emergency service, socializing the first aid for the incident victims, training dealing with the first aid of taking care of trauma victims, and promoting socialization for all citizens about the emergency numbers of health service institutions which could be immediately contacted when an accident occurs. There is a need for an emergency service system establishment and development.
Health and safety implementation in Indonesia and risk of COVID-19
Authors: Sudiarno Adithya , Diartiwi Sri Indriyani , Dewi Ratna Sari , Zulqornain M. Rizqi , Susanti Maria , Hermawan Edwin , Dedy Dedy , Arifin Syamsul , Wulansari Reni , Akbar Reza Aulia , Hidayat Muhammad Hendrawan , Feryanto Rico
Published: March 2021

The COVID-19 pandemic impacted the socio-economic sectors since the end of 2019. Indonesian’s Government issued the large-scale social restrictions policy to limit the industrial activities. This study aimed to investigate the difference of the health, safety, and environment (HSE) implementations among Indonesian companies, before and during the disruption risk of COVID-19 pandemic according to the use of personal protective equipment (PPE). It used a random sampling, involved 1,027 workers from various sectors of Indonesian companies. Hypothesis tests used are ANOVA and t-test method. The level of HSE compliance changed quite significantly when the COVID-19 outbreak emerged. The results explained, there is no significant difference in HSE compliance based on company location, company risk level, and position of a respondent in the company. However, there is a significant difference between companies that have a HSE division and a HSE Management System certificate with the company who did not have any. The recommendations of HSE improvement formulated using a Safety Model Canvas and a Focus Group Discussion conducted to convey the jazz scenario in the next normal. This study suggests the priority order for HSE improvement strategy in a company is commitment, responsibility, engagement and involvement, leadership, competence, information and communication, to organizational learning.
HDAC Inhibition Reverses Preexisting Diastolic Dysfunction and Blocks Covert Extracellular Matrix Remodeling
Authors: Travers Joshua G. , Wennersten Sara A. , Peña Brisa , Bagchi Rushita A. , Smith Harrison E. , Hirsch Rachel A. , Vanderlinden Lauren A. , Lin Ying-Hsi , Dobrinskikh Evgenia , Demos-Davies Kimberly M. , Cavasin Maria A. , Mestroni Luisa , Steinkühler Christian , Lin Charles Y. , Houser Steven R. , Woulfe Kathleen C. , Lam Maggie P.Y. , McKinsey Timothy A.
Published: March 2021

Background:

Diastolic dysfunction (DD) is associated with the development of heart failure and contributes to the pathogenesis of other cardiac maladies, including atrial fibrillation. Inhibition of histone deacetylases (HDACs) has been shown to prevent DD by enhancing myofibril relaxation. We addressed the therapeutic potential of HDAC inhibition in a model of established DD with preserved ejection fraction.

Methods:

Four weeks after uninephrectomy and implantation with deoxycorticosterone acetate pellets, when DD was clearly evident, 1 cohort of mice was administered the clinical-stage HDAC inhibitor ITF2357/Givinostat. Echocardiography, blood pressure measurements, and end point invasive hemodynamic analyses were performed. Myofibril mechanics and intact cardiomyocyte relaxation were assessed ex vivo. Cardiac fibrosis was evaluated by picrosirius red staining and second harmonic generation microscopy of left ventricle (LV) sections, RNA sequencing of LV mRNA, mass spectrometry–based evaluation of decellularized LV biopsies, and atomic force microscopy determination of LV stiffness. Mechanistic studies were performed with primary rat and human cardiac fibroblasts.

Results:

HDAC inhibition normalized DD without lowering blood pressure in this model of systemic hypertension. In contrast to previous models, myofibril relaxation was unimpaired in uninephrectomy/deoxycorticosterone acetate mice. Furthermore, cardiac fibrosis was not evident in any mouse cohort on the basis of picrosirius red staining or second harmonic generation microscopy. However, mass spectrometry revealed induction in the expression of >100 extracellular matrix proteins in LVs of uninephrectomy/deoxycorticosterone acetate mice, which correlated with profound tissue stiffening based on atomic force microscopy. ITF2357/Givinostat treatment blocked extracellular matrix expansion and LV stiffening. The HDAC inhibitor was subsequently shown to suppress cardiac fibroblast activation, at least in part, by blunting recruitment of the profibrotic chromatin reader protein BRD4 (bromodomain-containing protein 4) to key gene regulatory elements.

Conclusions:

These findings demonstrate the potential of HDAC inhibition as a therapeutic intervention to reverse existing DD and establish blockade of extracellular matrix remodeling as a second mechanism by which HDAC inhibitors improve ventricular filling. Our data reveal the existence of pathophysiologically relevant covert or hidden cardiac fibrosis that is below the limit of detection of histochemical stains such as picrosirius red, highlighting the need to evaluate fibrosis of the heart using diverse methodologies.
Ischemic Core Overestimation on Computed Tomography Perfusion
Authors: García-Tornel Álvaro , Campos Daniel , Rubiera Marta , Boned Sandra , Olivé-Gadea Marta , Requena Manuel , Ciolli Ludovico , Muchada Marian , Pagola Jorge , Rodriguez-Luna David , Deck Matias , Juega Jesus , Rodríguez-Villatoro Noelia , Sanjuan Estela , Tomasello Alejandro , Piñana Carlos , Hernández David , Álvarez-Sabin José , Molina Carlos A. , Ribó Marc
Published: March 2021

Background and Purpose:

Different studies have pointed that CT perfusion (CTP) could overestimate ischemic core in early time window. We aim to evaluate the influence of time and collateral status on ischemic core overestimation.

Methods:

Retrospective single-center study including patients with anterior circulation large-vessel stroke that achieved reperfusion after endovascular treatment. Ischemic core and collateral status were automatically estimated on baseline CTP using commercially available software. CTP-derived core was considered as tissue with a relative reduction of cerebral blood flow <30%, as compared with contralateral hemisphere. Collateral status was assessed using the hypoperfusion intensity ratio (defined by the proportion of the time to maximum of tissue residue function >6 seconds with time to maximum of tissue residue function >10 seconds). Final infarct volume was measured on 24 to 48 hours noncontrast CT. Ischemic core overestimation was considered when CTP-derived core was larger than final infarct.

Results:

Four hundred and seven patients were included in the analysis. Median CTP-derived core and final infarct volume were 7 mL (interquartile range, 0–27) and 20 mL (interquartile range, 5–55), respectively. Median hypoperfusion intensity ratio was 0.46 (interquartile range, 0.23–0.59). Eighty-three patients (20%) presented ischemic core overestimation (median overestimation, 12 mL [interquartile range, 41–5]). Multivariable logistic regression analysis adjusted by CTP-derived core and confounding variables showed that poor collateral status (per 0.1 hypoperfusion intensity ratio increase; adjusted odds ratio, 1.41 [95% CI, 1.20–1.65]) and earlier onset to imaging time (per 60 minutes earlier; adjusted odds ratio, 1.14 [CI, 1.04–1.25]) were independently associated with core overestimation. No significant association was found with imaging to reperfusion time (per 30 minutes earlier; adjusted odds ratio, 1.17 [CI, 0.96–1.44]). Poor collateral status influence on core overestimation differed according to onset to imaging time, with a stronger size of effect on early imaging patients(
P
interaction
<0.01).

Conclusions:

In patients with large-vessel stroke that achieve reperfusion after endovascular therapy, poor collateral status might induce higher rates of ischemic core overestimation on CTP, especially in patients in earlier window time. CTP reflects a hemodynamic state rather than tissue fate; collateral status and onset to imaging time are important factors to consider when estimating core on CTP.
A new species, Sursamucro rostratus sp. nov. (Copepoda, Calanoida) from the abyss of the northern Pacific and South Atlantic
Authors: Markhaseva Elena L. , Bradford-Grieve Janet M. , Renz Jasmin
Published: March 2021

A new calanoid copepod, Sursamucro rostratus sp. nov., belonging to the family Aetideidae, is described from female specimens collected in the northern Pacific and South Atlantic from abyssal waters close to the sea bed. The new species is the second of a rare deep-water genus, Sursamucro; it differs from its congener in size, configuration of the rostrum, the shape of the posterior corners of the prosome and details of antenna, mandible, maxillule and P1 setation. The genus Sursamucro is recorded for the first time from the northern Pacific and the Atlantic Ocean.
Children out of place? Negotiating children’s places from the margins
Authors: Henze-Pedersen Sofie
Published: March 2021

Inspired by a central concept in the sociology of childhood – that of ‘place’ – this article explores how childhood is constructed and experienced in an atypical place for childhood to unfold. The place in question is a refuge for women and their children who have experienced violence in the intimate sphere. In this article, ‘place’ has a dual meaning as referring to both social positions and physical locations. Employing this dual concept to investigate an atypical place provides insight into the dynamics that shape childhood space. Based on ethnographic fieldwork and interviews with children, the analysis shows how children negotiate children’s places in challenging circumstances in a semi-public setting. It uncovers the plurality of children’s places and how these are shaped by the children’s positions in a protective context. The plurality of children’s places becomes apparent by paying attention to the temporality of these places, which foregrounds the relational qualities and fields of power that contribute to the shaping of childhood space.
Novel scouring method of hemp fibers based on electrochemical techniques
Authors: Zhu Ruoying , Yu Ye , Yang Wenfang , Zhao Jin , Shi Guigang , Liu Jianyong
Published: March 2021

Hemp fiber has excellent performance as a renewable fiber material. It is of great significance to study more efficient, energy-saving and environmentally friendly pre-treatment methods of hemp textiles. A novel hemp fiber scouring method based on electrochemical techniques was presented in the research. A type of water solution with high and stable oxidative potential due to in-situ- generated oxidative components was produced by the proposed electrical method, and was applied to scouring treatment of raw hemp fibers by just soaking the fibers in it. Hemp fibers with different treatments were characterized by scanning electron microscopy, Fourier transform infrared spectroscopy and X-ray diffraction, and residual gum rate, lignin content and whiteness of the samples were tested. Experiment results show that electrochemical scouring has a similar degumming effect of hemp fibers compared with traditional chemical scouring, with a better lignin removal and whiteness, implying an effective and short process method of hemp textiles pre-treatment with low impact on the environment.
Real-time footstep planning including capture point trajectory optimization for stable biped navigation
Authors: Hong Young-Dae
Published: March 2021

For stable and efficient biped navigation, a real-time footstep planner taking bipedal dynamics for walking stability control into consideration is proposed. A capture point (CP)-based walking controller is utilized, and footstep planning including reference CP trajectory generation is formulated as an optimization problem. The footstep planning problem is solved using a particle swarm optimization algorithm. The walking period at every footstep is also planned to achieve more effective footstep planning, along with foot placement. Consequently, footstep placement, walking period, and reference CP trajectory for each footstep are optimized by the proposed method. The footstep optimization is performed in real-time without any approximations or precomputations. The effectiveness of the proposed method is demonstrated through experiments in a three-dimensional environment.
Managing the handling–comfort contradiction of a quarter-car system using Kalman filter
Authors: Muhammed Alhelou , Gavrilov Alexander
Published: March 2021

This article introduces a new approach to manage the “handling–comfort” contradiction of a vehicle suspension system. The idea is based on determining a specific time constant that reflects the percentage of suspension damping. This time constant is defined using the measurement of the sprung mass acceleration and the suspension deflection. A distinction is made between the control unit design for a semi-active suspension system and the control unit design for an active suspension system. The semi-active design is based on two sensors and a Kalman filter (KF), while the active design is based on three sensors and a dual-estimation KF. For active suspension, a third sensor was added to measure the acceleration of the unsprung mass. Simulation is carried out in Simulink and Simscape environments. The results of the proposed approach were compared with the results achieved by the hybrid-hook system. Simulation results showed a better efficiency of the proposed approach in driving safety during a “comfort” situation.
Cochlear Nerve Canal Stenosis: Association With MYH14 and MYH9 Genes
Authors: Liang Wenqi , Wang Line , Song Xinyu , Gao Fenqi , Liu Pan , Lee Tiffany H. , Peng Kevin A.
Published: March 2021

The bony cochlear nerve canal transmits the cochlear nerve as it passes from the fundus of the internal auditory canal to the cochlea. Stenosis of the cochlear nerve canal, defined as a diameter less than 1.0 mm in transverse diameter, is associated with inner ear anomalies and severe to profound congenital hearing loss. We describe an 11-month-old infant with nonsyndromic congenital sensorineural hearing loss with cochlear nerve canal stenosis. Next-generation sequencing revealed heterozygous mutations in MYH9 and MYH14, encoding for the inner ear proteins myosin heavy chain IIA and IIC. The patient’s hearing was rehabilitated with bilateral cochlear implantation.
Black–White Differences in the Link Between Offspring College Attainment and Parents’ Depressive Symptom Trajectories
Authors: Yahirun Jenjira , Sheehan Connor , Mossakowski Krysia
Published: March 2021

This study examines whether the relationship between children’s college attainment and their parents’ mental health differs for Black and White parents as they age. Data come from the U.S. Health and Retirement Study (HRS) and multilevel growth curve models are used to assess parents’ depressive symptom trajectories. Results indicated that parents over age 50 whose children all completed college had significantly lower initial levels of depressive symptoms than those with no college-educated children. The initial benefit was stronger for Blacks than Whites. Results stratified further by parents’ education show that Black parents at nearly all levels of schooling experienced stronger returns to their mental health from children’s college completion compared to White parents, for whom only those with a high school education showed an inverse association between offspring education and depression symptoms. The findings underscore how offspring education is a potential resource for reducing disparities in health across families.