bluuebunny/crossref_metadata_2025 huggingface dataset:
A Survey of Short-Range Wireless Communication for Ultra-Low-Power Embedded Systems
Authors: Baker Billy , Woods John , Reed Martin J. , Afford Martin
Published: May 2024

Wireless short-range communication has become widespread in the modern era, partly due to the advancement of the Internet of Things (IoT) and smart technology. This technology is now utilized in various sectors, including lighting, medical, and industrial applications. This article aims to examine the historical, present, and forthcoming advancements in wireless short-range communication. Additionally, the review will analyze the modifications made to communication protocols, such as Bluetooth, RFID and NFC, in order to better accommodate modern applications. Batteryless technology, particularly batteryless NFC, is an emerging development in short-range wireless communication that combines power and data transmission into a single carrier. This modification will significantly influence the trajectory of short-range communication and its applications. The foundation of most low-power, short-range communication applications relies on an ultra-low-power microcontroller. Therefore, this study will encompass an analysis of ultra-low-power microcontrollers and an investigation into the potential limitations they might encounter in the future. In addition to offering a thorough examination of current Wireless short-range communication, this article will also attempt to forecast future patterns and identify possible obstacles that future research may address.
Exploring the Gut Microbiome’s Role in Inflammatory Bowel Disease: Insights and Interventions
Authors: Gyriki Despoina , Nikolaidis Christos , Stavropoulou Elisavet , Bezirtzoglou Ioanna , Tsigalou Christina , Vradelis Stergios , Bezirtzoglou Eugenia
Published: May 2024

Inflammatory Bowel Disease (IBD), encompassing Crohn’s disease (CD) and ulcerative colitis (UC), is a chronic and relapsing inflammatory condition of the intestine that significantly impairs quality of life and imposes a heavy burden on healthcare systems globally. While the exact etiology of IBD is unclear, it is influenced by genetic, environmental, immunological, and microbial factors. Recent advances highlight the gut microbiome’s pivotal role in IBD pathogenesis. The microbial dysbiosis characteristic of IBD, marked by a decline in beneficial bacteria and an increase in pathogenic microbes, suggests a profound connection between microbial imbalance and disease mechanisms. This review explores diagnostic approaches to IBD that integrate clinical assessment with advanced microbiological analyses, highlighting the potential of microbiome profiling as a non-invasive diagnostic tool. In addition, it evaluates conventional and emerging treatments and discusses microbiome-targeted intervention prospects, such as probiotics, symbiotics, and faecal microbiota transplantation. The necessity for future research to establish their efficacy and safety is emphasised.
Analysis of Missingness Scenarios for Observational Health Data
Authors: Zamanian Alireza , von Kleist Henrik , Ciora Octavia-Andreea , Piperno Marta , Lancho Gino , Ahmidi Narges
Published: May 2024

Despite the extensive literature on missing data theory and cautionary articles emphasizing the importance of realistic analysis for healthcare data, a critical gap persists in incorporating domain knowledge into the missing data methods. In this paper, we argue that the remedy is to identify the key scenarios that lead to data missingness and investigate their theoretical implications. Based on this proposal, we first introduce an analysis framework where we investigate how different observation agents, such as physicians, influence the data availability and then scrutinize each scenario with respect to the steps in the missing data analysis. We apply this framework to the case study of observational data in healthcare facilities. We identify ten fundamental missingness scenarios and show how they influence the identification step for missing data graphical models, inverse probability weighting estimation, and exponential tilting sensitivity analysis. To emphasize how domain-informed analysis can improve method reliability, we conduct simulation studies under the influence of various missingness scenarios. We compare the results of three common methods in medical data analysis: complete-case analysis, Missforest imputation, and inverse probability weighting estimation. The experiments are conducted for two objectives: variable mean estimation and classification accuracy. We advocate for our analysis approach as a reference for the observational health data analysis. Beyond that, we also posit that the proposed analysis framework is applicable to other medical domains.
The Effect of Physiotherapy on Dyspnea, Muscle Strength and Functional Status in Patients with Long COVID Syndrome
Authors: Michalas Michail , Katsaras Stefanos , Spetsioti Stavroula , Spaggoulakis Dimitrios , Antonoglou Archontoula , Asimakos Andreas , Katsaounou Paraskevi , Christakou Anna
Published: May 2024

Background: Patients who were infected with COVID-19 may experience Long COVID syndrome. We examined the effectiveness of physiotherapy on dyspnea, muscle strength, and functional status in Long COVID syndrome. Methods: The exercise group underwent an 8-week supervised physiotherapeutic program consisting of interval aerobic exercise and strengthening exercises, each lasting 30 min. The control group did not engage in any exercise. Dyspnea, muscle strength, and functional status were assessed at the beginning and end of the intervention in both groups. Results: No significant baseline differences were found between the two groups. The exercise group demonstrated improvements compared to baseline in dyspnea, quadriceps muscle strength, and functional status. Specifically, there was a significant increase of 3.7 lifts in the 60-s sit-to-stand test (p = 0.01), an increase of 5.86 kg in right quadriceps muscle strength (p = 0.03), an increase of 8.26 kg in left quadriceps muscle strength (p = 0.01), and a decrease in dyspnea score by 0.95 points (p = 0.02). Conclusions: Similar studies have reported improvements in dyspnea, muscle strength, and functional status in the exercise group. However, further research with larger sample sizes is needed to confirm these findings.
Detailed Radiomorphometric Analysis of the Surgical Corridor for the Suprageniculate Approach
Authors: Wojciechowski Tomasz , Bisi Nicola , Szopiński Kazimierz , Marchioni Daniele
Published: May 2024

Background: The suprageniculate fossa (SGF) is located between the geniculate ganglion, the middle cranial fossa (MCF) and the anterior semicircular canal (ASCC). An endoscopic transcanal approach has been recently proposed to treat the different lesions in this area. The aim of the study is to describe the anatomical pathway of this approach by measuring the dimensions of its boundaries while checking their correlation with the pneumatization of the SGF area. Methods: This is a retrospective anatomical analysis of Cone Beam CT scans of 80 patients, for a total of 160 temporal bones analyzed. Two checkpoints were measured for the SGF route, as an internal and an external window. These are triangles between the MCF dura, the geniculate ganglion and the ASCC on parasagittal and axial planes. The pneumatization of the SGF was also assessed, classified and correlated with the measured dimensions. Results: The depth of the SGF was 7.5 ± 1.8 mm. The width of the external window was 7.5 ± 1.9, 5.6 ± 2.4 and 1.6 ± 1.6 mm for the posterior, middle and anterior points of measurement, respectively. The height of the internal window was 7.6 ± 1.2, 4.5 ± 1.5 and 1.7 ± 1.7 mm for the posterior, middle and anterior points of measurement, respectively. Type A pneumatization was found in 87 cases, type B in 34 and type C in 39. The degree of pneumatization directly correlated to the depth and height of the fossa. Conclusions: The suprageniculate approach route is defined by the internal and external windows which should be evaluated during a pre-surgery imaging assessment. The detailed anatomy of the approach and the novel classification of the pneumatization of the SGF are here described which may be useful to plan a safer procedure with minimal complications.
Misdiagnosis and Clinical Insights into Acral Amelanotic Melanoma—A Systematic Review
Authors: Cassalia Fortunato , Danese Andrea , Cocchi Enrico , Danese Elisabetta , Ambrogio Francesca , Cazzato Gerardo , Mazza Marcodomenico , Zambello Anna , Belloni Fortina Anna , Melandri Davide
Published: May 2024

Background: Acral amelanotic melanomas (AAMs), a rare subset of melanomas located on acral sites such as the palms, soles, and subungual areas, are diagnostically challenging due to their lack of typical pigmentation and often benign clinical appearance. Misdiagnosis is common, leading to delays in treatment and potentially worse outcomes. This systematic review aims to synthesise evidence on cases of AAM initially misdiagnosed as other conditions, to better understand their clinical and epidemiological characteristics, diagnostic pitfalls, and management strategies. Methods: A comprehensive search of the MEDLINE/PubMed, EMBASE, and SCOPUS databases was conducted up to March 2024. Case reports and small case series of AAMs initially misdiagnosed as other conditions were included. Data on patient demographics, clinical presentation, and diagnostic methods were collected and analyzed. Results: Of the 152 records identified, 26 cases from 23 articles met the inclusion criteria. A demographic analysis revealed that the gender distribution appears to be perfectly balanced, with an age range of 38 to 91 years. Misdiagnoses included non-healing ulcers or traumatic lesions (37.5%), benign proliferative lesions (29.2%) and infectious lesions (20.8%). The foot was the most affected site (53.8%). Notably, a histological evaluation was performed in 50% of cases involving the upper extremities, in contrast to only 7.1% of cases involving the foot and 0% of cases of the heel. This discrepancy suggests a reluctance to perform biopsies in the lower extremities, which may contribute to a higher misdiagnosis rate in these areas. Conclusions: The underutilization of biopsy in the diagnosis of lower extremity lesions contributes significantly to the misdiagnosis and delay in treatment of AAMs. Especially when the clinical assessment and dermoscopy are inconclusive, biopsies of suspicious lesions are essential. Immunohistochemistry and markers such as PRAME are critical in differentiating melanoma from other malignancies such as clear cell sarcoma. This review highlights the need for increased vigilance and a proactive diagnostic approach to increase early detection rates and improve prognostic outcomes.
Emotional State Measurement Trial (EMOPROEXE): A Protocol for Promoting Exercise in Adults and Children with Cerebral Palsy
Authors: Gómez-González Isabel M. , Castro-García Juan A. , Merino-Monge Manuel , Sánchez-Antón Gemma , Hamidi Foad , Mendoza-Sagrera Alejandro , Molina-Cantero Alberto J.
Published: May 2024

Background: The protocol described in this paper is part of a research project coordinated between three Spanish universities, where a technology aimed at improving the quality of life of people with cerebral palsy will be developed. Part of the proposed technology will consist of an interface and a series of applications to increase motivation for daily physical activity. The basis of these developments is the measurement of the emotional state of the subjects. Methods: The experimental protocol is designed with two research objectives, on the one hand to identify the emotional state through physiological signals, and on the other to determine whether music can be a motivating factor to promote physical activity. It is specifically designed for subjects with cerebral palsy, taking into account the special characteristics of this population. These are people with whom it is difficult to use questionnaires to have a basis to contrast with the measured physiological signals, so measurements must be taken in carefully chosen daily-life situations. Discussion: We hope our findings show which physiological parameters are the most robust to measure the emotional state and how to design rehabilitation and physical activity promotion routines that are motivating, in addition to being able to avoid risk factors during the performance of these routines. Trial registration: NCT05621057.
Ending an Odyssey? The Psychosocial Experiences of Parents after the Genetic Diagnosis of a Mitochondrial Disease in Children
Authors: Heath Oliver , Hammerl Emma , Spitzinger Anna , Wortmann Saskia B.
Published: May 2024

Obtaining a genetic diagnosis of a primary mitochondrial disease (PMD) is often framed as a diagnostic odyssey. Yet, even after receiving a diagnosis, parents of affected children experience ongoing therapeutic and prognostic uncertainty and considerable psychosocial challenges. Semi-structured interviews (N = 24) were conducted with parents of 13 children (aged 2–19 years) with a genetically confirmed PMD. Paternal (N = 11) and maternal (N = 13) perspectives were obtained, and thematic analysis was performed on all interviews. A genetic diagnosis was valuable and empowering for parents, despite eliciting varied emotional responses. While the diagnosis helped focus management decisions, families often felt overwhelmed and unsupported in navigating the healthcare system. Most parents reported a serious impact on their romantic relationship. The sources of social support varied, with a preference for established friendship and family support networks over disease-specific community support groups. Most parents favored prenatal genetic testing in the event of a future pregnancy. This study provides insight into the lived experiences of parents after a genetic diagnosis of PMD in their children. The findings draw awareness to supportive care needs and highlight important gaps that should be addressed to ensure that parents feel supported within a holistic framework of management for PMDs.
The Agro-Pastoral Transitional Zone in Northern China: Continuously Intensifying Land Use Competition Leading to Imbalanced Spatial Matching of Ecological Elements
Authors: Wang Kaige , Zhao Xiangyu , Zheng Huihui , Zheng Bangyou , Xu Yan , Zhang Fengrong , Duan Zengqiang
Published: May 2024

The agro-pastoral transitional zone (APTZ) in northern China is a typical ecologically vulnerable zone and a comprehensive geographical transitional zone. Its land use pattern has significant type diversity and spatial interlocking, which is always related to the play of ecological barrier functions and the sustainability of social-ecological systems. Accurately grasping the spatial competition relationship and comprehensive geographical effects of land types of APTZ in northern China is a key proposition for achieving coordinated and sustainable development between humans and land. To explore the spatial competition mechanism and comprehensive geographical effects of land use in the research area, this study focuses on revealing the evolutionary characteristics of land use patterns based on the center of gravity migration model. Based on the process of land use center of gravity migration, the spatial competition relationship of land types is explored to reveal the evolutionary trend and basic characteristics of land use in the APTZ. The results show the following: (1) Cultivated land and meadow are the main land types of the APTZ in northern China, accounting for up to 70% of the total regional area. The spatial competition between the two land types is the main contradiction in regional land use competition. (2) Drifting of the center of gravity of cultivated land towards the northwest direction is an important land use migration feature of the APTZ in northern China. Between 1980 and 2020, the center of gravity of cultivated land shifted by about 2 km to the northwest, and the center of gravity of grassland shifted by 8–10 km to the southwest. (3) The center of gravity of arable land and grassland in the entire region is constantly approaching, which has decreased from 70.95 km in 1980 to 61.38 km in 2020. The intensification of their interweaving has led to more intense land use competition. Grasping the basic characteristics and driving mechanisms of land type competition is an important means to achieve sustainable spatial governance. (4) The scale differentiation and regional differentiation characteristics of gradient effects are significant, and it is essential to prevent the risk of mismatch between land use and natural endowments in the northeast and north China sections. The research has surpassed the traditional method of analyzing land use competition, and by introducing a centroid model to analyze the spatial mechanism of land use competition, it has expanded the methodology for expanding research in the field of land science and provided basic references for regional sustainable development.
Bibliometric and Visualization Analysis of the Literature on the Remote Sensing Inversion of Soil Salinization from 2000 to 2023
Authors: Yin Chengshen , Liu Quanming , Ma Teng , Shi Yanru , Wang Fuqiang
Published: May 2024

Tracing the historical development of soil salinization and monitoring its current status are crucial for understanding the driving forces behind it, proposing strategies to improve soil quality, and predicting future trends. To comprehensively understand the evolution of research on the remote sensing inversion of soil salinity, a scientific bibliometric analysis was conducted on research from the past two decades indexed in the core scientific databases. This article analyzes the field from various perspectives, including the number of publications, authors, research institutions and countries, research fields, study areas, and keywords, in order to reveal the current state-of-the-art and cutting-edge research in this domain. Special attention was given to topics such as machine learning, data assimilation methods, unmanned aerial vehicle (UAV) remote sensing technology, soil inversion under vegetation cover, salt ion inversion, and remote sensing model construction methods. The results indicate an overall increase in the volume of publications, with key authors such as Metternicht, Gi and Zhao, Gengxing, and major research institutions including the International Institute for Geoinformatics Science and Earth Observation and the Chinese Academy of Sciences making significant contributions. Notably, China and the USA have made substantial contributions to this field, with research areas extending from Inner Mongolia’s Hetao irrigation district to the Mediterranean region. Research in the remote sensing domain focuses on various methods, including hyperspectral imaging for salinized soil inversion, with an increasing emphasis on machine learning. This study enriches researchers’ knowledge of the current trends and future directions of remote sensing inversion of soil salinization.
A Land Cover Change Detection Approach to Assess the Effectiveness of Conservation Projects: A Study Case on the EU-Funded LIFE Projects in São Miguel Island, Azores (2002–2021)
Authors: Tiengo Rafaela , Merino-De-Miguel Silvia , Uchôa Jéssica , Gil Artur
Published: May 2024

Small oceanic islands, such as São Miguel Island in the Azores (Portugal), face heightened susceptibility to the adverse impacts of climate change, biological invasions, and land cover changes, posing threats to biodiversity and ecosystem functions and services. Over the years, persistent conservation endeavors, notably those supported by the EU LIFE Programme since 2003, have played a pivotal role in alleviating biodiversity decline, particularly in the eastern region of São Miguel Island. This study advocates the application of remote sensing data and techniques to support the management and effective monitoring of LIFE Nature projects with land cover impacts. A land cover change detection approach utilizing Rao’s Q diversity index identified and assessed changes from 2002 to 2021 in intervention areas. The study analyzed the changes in LIFE project areas using ASTER, Landsat 8, and Sentinel 2 data through Google Earth Engine on Google Colab (with Python). This methodological approach identified and assessed land cover changes in project intervention areas within defined timelines. This technological integration enhances the potential of remote sensing for near-real-time monitoring of conservation projects, making it possible to assess their land cover impacts and intervention achievements.
Unraveling the Dynamic Relationship between Neighborhood Deprivation and Walkability over Time: A Machine Learning Approach
Authors: Wang Qian , Li Guie , Weng Min
Published: May 2024

Creating a walkable environment is an essential step toward the 2030 Sustainable Development Goals. Nevertheless, not all people can enjoy a walkable environment, and neighborhoods with different socioeconomic status are found to vary greatly with walkability. Former studies have typically unraveled the relationship between neighborhood deprivation and walkability from a temporally static perspective and the produced estimations to a point-in-time snapshot were believed to incorporate great uncertainties. The ways in which neighborhood walkability changes over time in association with deprivation remain unclear. Using the case of the Hangzhou metropolitan area, we first measured the neighborhood walkability from 2016 to 2018 by calculating a set of revised walk scores. Further, we applied a machine learning algorithm, the kernel-based regularized least squares regression in particular, to unravel how neighborhood walkability changes in relation to deprivation over time. The results not only capture the nonlinearity in the relationship between neighborhood deprivation and walkability over time, but also highlight the marginal effects of each neighborhood deprivation indicator. Additionally, comparisons of the outputs between the machine learning algorithm and OLS regression illustrated that the machine learning approach did tell a different story and should contribute to remedying the contradictory conclusions in earlier studies. This paper is believed to renew the understanding of social inequalities in walkability by bringing the significance of temporal dynamics and structural interdependences to the fore.
Institutional, Ecological, Economic, and Socio-Cultural Sustainability—Evidence from Ponjavica Nature Park
Authors: Ristić Vladica , Trišić Igor , Štetić Snežana , Maksin Marija , Nechita Florin , Candrea Adina Nicoleta , Pavlović Marko , Hertanu Andreea
Published: May 2024

The Nature Park Ponjavica (NP) is the habitat of strictly protected plant and animal species, located in AP Vojvodina, in southern Banat (Northern Serbia). The area of the park covers 302.96 ha. Protection zones I, II, and III have been established in the protected area of the NP. The NP includes the middle course of the Ponjavica River, which has preserved characteristics of watercourses of plain areas and coastal remains of wetland habitats. The most valuable area of this park in terms of protection is an island with an area of slightly less than 1 hectare. According to the IUCN (International Union for Conservation of Nature), the NP is classified as the fourth category—Habitat and species management area. The good geographical position of NP is one of its main characteristics. The NP can be a destination where specific forms of tourism can be developed, such as ecotourism, nature-based tourism, birdwatching, scientific and research tourism, etc. Numerous historical sites represent a significant potential for the development of cultural tourism. The research examined the influence of institutional, economic, ecological, and socio-cultural sustainability on the respondents’ satisfaction. The quantitative methodology in this research included a questionnaire as a survey instrument for respondents. A total of 547 residents were surveyed. The results of the research indicate that there is considerable satisfaction among residents with sustainable tourism. The results of the research can help in the development of numerous tourism development strategies in which the wetland is the primary resource.
A New Approach to Landscape Visual Quality Assessment from a Fine-Tuning Perspective
Authors: Fan Rong , Chen Yingze , Yocom Ken P.
Published: May 2024

Various methods for evaluating the visual quality of landscapes have been continuously studied. In the era of the rapid development of big data, methods to obtain evaluation data efficiently and accurately have received attention. However, few studies have been conducted to optimize the evaluation methods for landscape visual quality. Here, we aim to develop an evaluation model that is model fine-tuned using Scenic Beauty Evaluation (SBE) results. In elucidating the methodology, it is imperative to delve into the intricacies of refining the evaluation process. First, fine-tuning the model can be initiated with a scoring test on a small population, serving as an efficient starting point. Second, determining the optimal hyperparameter settings necessitates establishing intervals within a threshold range tailored to the characteristics of the dataset. Third, from the pool of fine-tuned models, selecting the one exhibiting optimal performance is crucial for accurately predicting the visual quality of the landscape within the study population. Lastly, through the interpolation process, discernible differences in landscape aesthetics within the core monitoring area can be visually distinguished, thereby reinforcing the reliability and practicality of the new method. In order to demonstrate the efficiency and practicality of the new method, we chose the core section of the famous Beijing–Hangzhou Grand Canal in Wujiang District, China, as a case study. The results show the following: (1) Fine-tuning the model can start with a scoring test on a small population. (2) The optimal hyperparameter setting intervals of the model need to be set in a threshold range according to different dataset characteristics. (3) The model with optimal performance is selected among the four fine-tuning models for predicting the visual quality of the landscape in the study population. (4) After the interpolation process, the differences in landscape aesthetics within the core monitoring area can be visually distinguished. We believe that the new method is efficient, accurate, and practically applicable for improving landscape visual quality evaluation.
Temporal and Spatial Response of Ecological Environmental Quality to Land Use Transfer in Nanling Mountain Region, China Based on RSEI: A Case Study of Longnan City
Authors: Xiong Qiulin , Hong Qingwen , Chen Wenbo
Published: May 2024

Nanling Mountain region is a typical southern hilly region, which plays an important ecological and environmental protection role in China’s overall land protection pattern. Based on the remote sensing image data of Longnan City in Nanling Mountain region in 2013, 2018 and 2023, this paper interpreted the land use type and analyzed the land use transfer situation by using land use transfer flow, and a land use transfer matrix. At the same time, based on the remote sensing ecological index (RSEI) model, the ecological environmental quality of Longnan City from 2013 to 2023 was retrieved. The temporal and spatial response model of the ecological environmental quality to land use transfer in Longnan City from 2013 to 2023 was discussed based on spatial autocorrelation and a geographical detector. The results show that from 2013 to 2023, the decrease of forest land (16.23 km2) and the increase of construction land (13.25 km2) were the main land use transfers in Longnan City. The ecological environment indexes of Longnan City in 2013, 2018 and 2023 were 0.789, 0.917 and 0.872, respectively, showing a trend of “first rising and then decreasing”. The ecological environmental quality in the north of Longnan City was significantly lower than that in the south, and the poor ecological quality area appeared in and around the northern main urban area, showing a trend of “inward contraction”. Forest land, garden land, grassland, cultivated land and water area have a positive impact on ecological environmental quality, while traffic land, construction land and other land have a negative impact on ecological environmental quality. The response of ecological environmental quality to different land use transfer modes is related to the change of the overall ecological environmental quality. The interaction between land use and land cover change (LUCC) and other factors had a great impact on the evolution of ecological environmental quality in Longnan City.
Has the Establishment of National Key Ecological Function Zones Improved Eco-Environmental Quality?—Evidence from a Quasi-Natural Experiment in 130 Counties in Sichuan Province, China
Authors: Deng Yuanjie , Ming Lu , Hai Yifeng , Chen Hang , Jize Dingdi , Luo Ji , Yan Xiaohan , Zhang Xiaolong , Yao Shunbo , Hou Mengyang
Published: May 2024

China’s National Key Ecological Function Zones (NKEFZs) currently represent the largest and most extensive ecological conservation policy in China, with one of the core objectives of this policy being to improve eco-environmental quality (EEQ). This study regards the establishment of NKEFZs as a quasi-natural experiment. Based on panel data from 130 counties in Sichuan Province from 2001 to 2021, a multi-period difference-in-differences (DID) model was employed to evaluate the impact of NKEFZ establishment on EEQ. The findings indicate the following: ① The establishment of NKEFZs can significantly enhance the EEQ of the covered areas, albeit as a gradual long-term process. This conclusion not only meets the parallel-trends assumption but also holds true in a series of robustness tests such as placebo tests. ② Mechanism analysis reveals that NKEFZs can enhance EEQ through the effects of optimizing land spatial allocation and upgrading industrial structure. ③ Heterogeneity analysis demonstrates that the beneficial effect of NKEFZs on EEQ varies across different functional zone types, geographic spaces and ethnic regions. Our study not only contributes to the accumulation of empirical evidence and institutional refinement in the sustainable implementation of ecological policies in China but also offers valuable insights and references for other countries in formulating policies for eco-environmental protection.
Unraveling Urban Disaster Management: A Deep Dive into SETS Implications through a Case Study of Toyama City, Japan
Authors: Lee Yujeong , Hong Changyu
Published: May 2024

This study uses the Social–Ecological–Technological Systems (SETS) framework to examine the urban disaster management strategies of Toyama City, Japan. The recent seismic shocks on the Noto Peninsula highlight the importance of implementing efficient disaster management. Toyama City has incorporated the United Nations’ Sustainable Development Goals into its statutory planning frameworks and urban management policies. This synthesis promotes a cooperative approach to disaster resilience while effectively managing challenging limitations. However, we investigate how Toyama City’s policy may be improved using policy direction evaluation and SETS allomorph coding. This extensive allomorph analysis of the city’s urban planning and disaster management documents shows a dominant focus on social and technical elements, including emergency preparedness, policy, economic criteria, and infrastructure. Nevertheless, the results reveal a significant deficiency in ecological considerations, indicating an asymmetry in the existing policy framework. Our study emphasizes the need for a comprehensive disaster management strategy that considers social, technological, and ecological variables to improve the city’s ability to support sustainable development and socio-hydrological challenges.
Identification of Critical Areas of Openness–Vitality Intensity Imbalance in Waterfront Spaces and Prioritization of Interventions: A Case Study of Xiangjiang River in Changsha, China
Authors: Zhou Zhaoyu , Yang Fan , Li Jiayu , Li Jiale , Zou Zhuojun
Published: May 2024

To alleviate the contradiction between high-density urban spatial environments and high-frequency citizens’ activities, it is vital to determine the degree of openness of waterfront space, figure out the matching relationship between spatial openness and vitality intensity, identify imbalanced spatial zones and divide the order of intervention, and compensate for the limitations of subjective judgment in traditional planning decisions. This paper uses the Changsha Xiangjiang River waterfront space as a research sample based on multi-source data. It constructs the evaluation indicators system and research framework for the degree of openness of waterfront space. Then, by evaluating the openness and vitality intensity of the waterfront space and adopting the quadrant division method, waterfront space zones with a mismatched openness and vitality intensity were identified. Finally, planning interventions are prioritized based on a priority index. The results show the following: (1) The openness and vitality of the waterfront space of Xiangjiang River show the spatial distribution characteristics of “high in the middle and low in the north and south” and “high on the east bank and low on the west bank”. (2) Fifteen low-quality waterfront spatial zones with “low vitality intensity and low openness” and one with a severe imbalance of “low openness–high vitality intensity” were identified. These waterfront spatial zones cannot meet the requirements for the high-quality development of waterfront space. (3) The study delineates five priority levels for planning interventions. Among them, three waterfront space zones belong to priority V, mainly distributed north and south of the Xiangjiang River. Five waterfront spatial zones belonging to priority IV are concentrated in the middle of the Xiangjiang River. The above areas need to be prioritized for improvement to accurately promote the overall balanced development of the waterfront space.
Exploring Semanticity for Content and Function Word Distinction in Catalan
Authors: Català Neus , Baixeries Jaume , Hernández-Fernández Antoni
Published: May 2024

In the realm of linguistics, the concept of “semanticity” was recently introduced as a novel measure designed to study linguistic networks. In a given text, semanticity is defined as the ratio of the potential number of meanings associated with a word to the number of different words with which it is linguistically linked. This concept provides a quantitative indicator that reflects a word’s semantic complexity and its role in a language. In this pilot study, we applied the semanticity measure to the Catalan language, aiming to investigate its effectiveness in automatically distinguishing content words from function words. For this purpose, the measure of semanticity has been applied to a large corpus of texts written in Catalan. We show that the semanticity of words allows us to classify the word classes existing in Catalan in a simple way so that both the semantic and syntactic capacity of each word within a language can be integrated under this parameter. By means of this semanticity measure, it has been observed that adverbs behave like function words in Catalan. This approach offers a quantitative and objective tool for researchers and linguists to gain insights into the structure and dynamics of languages, contributing to a deeper understanding of their underlying principles. The application of semanticity to Catalan is a promising pilot study, with potential applications in other languages, which will allow progress to be made in the field of theoretical linguistics and contribute to the development of automated linguistic tools.
Vitamin D: A Bridge between Kidney and Heart
Authors: Secondulfo Carmine , Visco Valeria , Virtuoso Nicola , Fortunato Martino , Migliarino Serena , Rispoli Antonella , La Mura Lucia , Stellato Adolfo , Caliendo Giuseppe , Settembre Emanuela , Galluccio Fabiana , Hamzeh Sarah , Bilancio Giancarlo
Published: May 2024

Chronic kidney disease (CKD) and cardiovascular disease (CVD) are highly prevalent conditions, each significantly contributing to the global burden of morbidity and mortality. CVD and CKD share a great number of common risk factors, such as hypertension, diabetes, obesity, and smoking, among others. Their relationship extends beyond these factors, encompassing intricate interplay between the two systems. Within this complex network of pathophysiological processes, vitamin D has emerged as a potential linchpin, exerting influence over diverse physiological pathways implicated in both CKD and CVD. In recent years, scientific exploration has unveiled a close connection between these two prevalent conditions and vitamin D, a crucial hormone traditionally recognized for its role in bone health. This article aims to provide an extensive review of vitamin D’s multifaceted and expanding actions concerning its involvement in CKD and CVD.
Modulation of Tropane Alkaloids’ Biosynthesis and Gene Expression by Methyl Jasmonate in Datura stramonium L.: A Comparative Analysis of Scopolamine, Atropine, and Hyoscyamine Accumulation
Authors: Rasi Arash , Sabokdast Manijeh , Naghavi Mohammad Reza , Jariani Parisa , Dedičová Beáta
Published: May 2024

Scopolamine and atropine are two medicinal alkaloids derived from Datura stramonium L. with anticholinergic properties. This study explored how methyl jasmonate (MJ), a plant growth regulator, affects the biosynthesis and accumulation of these alkaloids in different plant tissues. The expression levels of putrescine N-methyltransferase (PMT), tropinone reductase I (TR1), and hyoscyamine 6β-hydroxylase (h6h), three critical enzymes in the biosynthetic pathway, were also analyzed. The results indicated that MJ at 150 µM increased the production of scopolamine and atropine in both leaves and roots, while MJ at 300 µM had an adverse effect. Furthermore, MJ enhanced the expression of PMT, TR1, and h6h genes in the roots, the primary site of alkaloid synthesis, but not in the leaves, the primary site of alkaloid storage. These results imply that MJ can be applied to regulate the biosynthesis and accumulation of scopolamine and atropine in D. stramonium, thereby improving their production efficiency.
Dried Plasma for Major Trauma: Past, Present, and Future
Authors: Peng Henry T. , Singh Kanwal , Rhind Shawn G. , da Luz Luis , Beckett Andrew
Published: May 2024

Uncontrollable bleeding is recognized as the leading cause of preventable death among trauma patients. Early transfusion of blood products, especially plasma replacing crystalloid and colloid solutions, has been shown to increase survival of severely injured patients. However, the requirements for cold storage and thawing processes prior to transfusion present significant logistical challenges in prehospital and remote areas, resulting in a considerable delay in receiving thawed or liquid plasma, even in hospitals. In contrast, freeze- or spray-dried plasma, which can be massively produced, stockpiled, and stored at room temperature, is easily carried and can be reconstituted for transfusion in minutes, provides a promising alternative. Drawn from history, this paper provides a review of different forms of dried plasma with a focus on in vitro characterization of hemostatic properties, to assess the effects of the drying process, storage conditions in dry form and after reconstitution, their distinct safety and/or efficacy profiles currently in different phases of development, and to discuss the current expectations of these products in the context of recent preclinical and clinical trials. Future research directions are presented as well.
Correction: Pruvost, M.; Moyon, S. Oligodendroglial Epigenetics, from Lineage Specification to Activity-Dependent Myelination. Life 2021, 11, 62
Authors: Pruvost Mathilde , Moyon Sarah
Published: May 2024

The authors wish to make the following corrections to this paper [...]
Impact of Replacement Therapy on Pregnancy Outcomes in Hemophilia Carriers: A Historical Cohort Study in Saudi Arabia
Authors: Bakhsh Ebtisam
Published: May 2024

This retrospective cohort study evaluates the safety and efficacy of replacement therapy with regard to pregnancy outcomes in hemophilia carriers. Hemophilia carriers face elevated bleeding risks during pregnancy, necessitating meticulous management, including replacement therapy with clotting factors. This research examines the records of 64 pregnant hemophilia carriers at King Fahad Medical City, Riyadh, from January 2010 to December 2023, analyzing their demographic details, hemophilia type and severity, replacement therapy specifics, and pregnancy outcomes. The study found that 62.5% of the participants had hemophilia A, with 43.8% categorized as severe. Most subjects (87.5%) received recombinant factor VIII at a median dosage of 30 IU/kg weekly. Adverse pregnancy outcomes included gestational hypertension (15.6%), preterm labor (18.8%), and postpartum hemorrhage (12.5%). The cesarean section rate was 28.1%. Neonatal outcomes were generally favorable, with median birth weights at 3100 g and mean Apgar scores of 8.2 and 9.1 at 1 and 5 min, respectively. Logistic regression analysis revealed no significant association between adverse events and therapy type or dosage, though a trend towards significance was noted with once-weekly administration (p = 0.082). The study concludes that replacement therapy is a viable method for managing hemophilia in pregnant carriers, leading to generally favorable maternal and neonatal outcomes. However, it underscores the importance of individualized treatment plans and close monitoring to effectively manage the risks associated with hemophilia during pregnancy.
Familial Alzheimer’s Disease Neurons Bearing Mutations in PSEN1 Display Increased Calcium Responses to AMPA as an Early Calcium Dysregulation Phenotype
Authors: Targa Dias Anastacio Helena , Matosin Natalie , Ooi Lezanne
Published: May 2024

Familial Alzheimer’s disease (FAD) can be caused by mutations in PSEN1 that encode presenilin-1, a component of the gamma-secretase complex that cleaves amyloid precursor protein. Alterations in calcium (Ca2+) homeostasis and glutamate signaling are implicated in the pathogenesis of FAD; however, it has been difficult to assess in humans whether or not these phenotypes are the result of amyloid or tau pathology. This study aimed to assess the early calcium and glutamate phenotypes of FAD by measuring the Ca2+ response of induced pluripotent stem cell (iPSC)-derived neurons bearing PSEN1 mutations to glutamate and the ionotropic glutamate receptor agonists NMDA, AMPA, and kainate compared to isogenic control and healthy lines. The data show that in early neurons, even in the absence of amyloid and tau phenotypes, FAD neurons exhibit increased Ca2+ responses to glutamate and AMPA, but not NMDA or kainate. Together, this suggests that PSEN1 mutations alter Ca2+ and glutamate signaling as an early phenotype of FAD.
Advancing Microbiology through the Discovery of New Microbial Species and Strains
Authors: Rampelotto Pabulo Henrique
Published: May 2024

In our pursuit of understanding the intricacies of microbial life, the isolation and characterization of new microbial species and strains play a pivotal role [...]
Experimental Study of the Implantation Process for Array Electrodes into Highly Transparent Agarose Gel
Authors: Wang Shengjie , Yan Xuan , Jiao Xuefeng , Yang Heng
Published: May 2024

Brain–computer interface (BCI) technology is currently a cutting-edge exploratory problem in the field of human–computer interaction. However, in experiments involving the implantation of electrodes into brain tissue, particularly high-speed or array implants, existing technologies find it challenging to observe the damage in real time. Considering the difficulties in obtaining biological brain tissue and the challenges associated with real-time observation of damage during the implantation process, we have prepared a transparent agarose gel that closely mimics the mechanical properties of biological brain tissue for use in electrode implantation experiments. Subsequently, we developed an experimental setup for synchronized observation of the electrode implantation process, utilizing the Digital Gradient Sensing (DGS) method. In the single electrode implantation experiments, with the increase in implantation speed, the implantation load increases progressively, and the tissue damage region around the electrode tip gradually diminishes. In the array electrode implantation experiments, compared to a single electrode, the degree of tissue indentation is more severe due to the coupling effect between adjacent electrodes. As the array spacing increases, the coupling effect gradually diminishes. The experimental results indicate that appropriately increasing the velocity and array spacing of the electrodes can enhance the likelihood of successful implantation. The research findings of this article provide valuable guidance for the damage assessment and selection of implantation parameters during the process of electrode implantation into real brain tissue.
Simultaneous Li-Doping and Formation of SnO2-Based Composites with TiO2: Applications for Perovskite Solar Cells
Authors: Hattori Nagisa , Manseki Kazuhiro , Hibi Yuto , Nagaya Naohide , Yoshida Norimitsu , Sugiura Takashi , Vafaei Saeid
Published: May 2024

Tin oxide (SnO2) has been recognized as one of the beneficial components in the electron transport layer (ETL) of lead–halide perovskite solar cells (PSCs) due to its high electron mobility. The SnO2-based thin film serves for electron extraction and transport in the device, induced by light absorption at the perovskite layer. The focus of this paper is on the heat treatment of a nanoaggregate layer of single-nanometer-scale SnO2 particles in combination with another metal-dopant precursor to develop a new process for ETL in PSCs. The combined precursor solution of Li chloride and titanium(IV) isopropoxide (TTIP) was deposited onto the SnO2 layer. We varied the heat treatment conditions of the spin-coated films comprising double layers, i.e., an Li/TTIP precursor layer and SnO2 nanoparticle layer, to understand the effects of nanoparticle interconnection via sintering and the mixing ratio of the Li-dopant on the photovoltaic performance. X-ray diffraction (XRD) and high-resolution transmission electron microscopy (HR-TEM) measurements of the sintered nanoparticles suggested that an Li-doped solid solution of SnO2 with a small amount of TiO2 nanoparticles formed via heating. Interestingly, the bandgap of the Li-doped ETL samples was estimated to be 3.45 eV, indicating a narrower bandgap as compared to that of pure SnO2. This observation also supported the formation of an SnO2/TiO2 solid solution in the ETL. The utilization of such a nanoparticulate SnO2 film in combination with an Li/TTIP precursor could offer a new approach as an alternative to conventional SnO2 electron transport layers for optimizing the performance of lead–halide perovskite solar cells.