bluuebunny/crossref_metadata_2025 huggingface dataset:
Preoperative and intraoperative assessment of myometrial invasion in patients with FIGO stage I non-endometrioid endometrial carcinoma—a large-scale, multi-center, and retrospective study
Authors: Yang Xiaohang , Yin Jingjing , Fu Yu , Shen Yuanming , Zhang Chuyao , Yao Shuzhong , Xu Congjian , Xia Min , Lou Ge , Liu Jihong , Lin Bei , Wang Jianliu , Zhao Weidong , Zhang Jieqing , Cheng Wenjun , Guo Hongyan , Guo Ruixia , Xue Fengxia , Wang Xipeng , Han Lili , Li Xiaomao , Zhang Ping , Zhao Jianguo , Li Wenting , Dou Yingyu , Wang Zizhuo , Liu Jingbo , Li Kezhen , Chen Gang , Sun Chaoyang , Sun Pengming , Lu Weiguo , Yao Qin
Published: January 2023

Introduction

Myometrial invasion is a prognostic factor for lymph node metastases and decreased survival in non-endometrioid endometrial carcinoma patients. Herein, we explored the mode of myometrial invasion diagnosis in FIGO stage I non-endometrioid carcinoma and evaluated the differences in diagnostic efficiency among intraoperative frozen section (IFS), intraoperative gross examination (IGE), magnetic resonance imaging (MRI), and computed tomography (CT) in clinical practice. Finally, we suggested which test should be routinely performed.

Method

This was a historical cohort study nationwide with 30 centers in China between January 2000 and December 2019. Clinical data, including age, histology, method of myometrial invasion evaluation (MRI, CT, IGE, and IFS), and final diagnosis of postoperative paraffin sections, were collected from 490 non-endometrioid endometrial carcinoma (serous, clear cell, undifferentiated, mixed carcinoma, and carcinosarcoma) women in FIGO stage I.

Results

Among the 490 patients, 89.59% presented myometrial invasion. The methods reported for myometrial invasion assessment were IFS in 23.47%, IGE in 69.59%, MRI in 37.96%, and CT in 10.20% of cases. The highest concordance was detected between IFS and postoperative paraffin sections (Kappa = 0.631, accuracy = 93.04%), followed by IGE (Kappa = 0.303, accuracy = 82.40%), MRI (Kappa = 0.131, accuracy = 69.35%), and CT (Kappa = 0.118, accuracy = 50.00%). A stable diagnostic agreement between IFS and the final results was also found through the years (2000–2012: Kappa = 0.776; 2013–2014: Kappa = 0.625; 2015–2016: Kappa = 0.545; 2017–2019: Kappa = 0.652).

Conclusion

In China, the assessment of myometrial invasion in non-endometrioid endometrial carcinoma is often performed via IGE, but the reliability is relatively low in contrast to IFS. In clinical practice, IFS is a reliable method that can help accurately assess myometrial invasion and intraoperative decision-making (lymph node dissection or not). Hence, it should be routinely performed in non-endometrioid endometrial carcinoma patients.
Effect of blended and unguided online delivery of mindfulness-based cognitive therapy versus care as usual on distress among cancer patients and survivors: protocol for the three-arm parallel randomized controlled buddy trial
Authors: Badaghi Nasim , van Kruijsbergen Mette , Prins Judith , Kelders Saskia , Cillessen Linda , Compen Félix , Donders Rogier , Kwakkenbos Linda , Speckens Anne
Published: January 2023

Background

One third of cancer patients and survivors experience psychological distress. Previous studies have shown that online mindfulness-based cognitive therapy (eMBCT) supports cancer patients and survivors in managing distress. Lack of peer support and asynchronicity during online interventions have been reported as barriers for treatment adherence and can result in higher drop-out rates. Considering this, two new formats of eMBCT were created. The primary objective of the Buddy trial is to evaluate the (cost) effectiveness of blended and unguided eMBCT versus care as usual (CAU) on psychological distress among cancer patients and survivors. Secondary objectives include evaluating effects on other psychological outcomes and investigating working mechanisms and treatment effect moderators.

Methods

The Buddy trial is a parallel three-armed randomized controlled trial. Participants will be randomly assigned to blended therapist-assisted eMBCT, unguided individual eMBCT or CAU. Eligible participants will be Dutch-speaking adult cancer patients or survivors with access to internet. The primary outcome will be psychological distress scores as assessed by the Hospital Anxiety and Depression scale immediately post-treatment. Secondary outcome measures include fear of cancer recurrence (FCRI), fatigue (CIS-F), rumination (RRQ), mindfulness skills (FFMQ), decentering (EQ), self-compassion (SCS-SF), positive mental health (MHCSF), health related quality of life (EQ-5D), and costs associated with psychiatric illness (TiC-P). Outcome measures will be evaluated at baseline, mid-treatment, immediately post-treatment, and three-, six-, and nine-months follow-up. Possible mediators, such as engagement with interventions (TWEETS), and moderators will be also analyzed.

Discussion

There is room to improve eMBCT for cancer patients prior to implementation to ensure adherence and scalability. Blended and unguided eMBCT may reduce psychological distress and improve quality of life and be easily accessible to cancer patients and survivors.

Trial registration clinicaltrials.gov, NCT05336916, registered on April 20th, 2022. https://clinicaltrials.gov/ct2/show/NCT05336916.
Determining the impact of cannabis use and severity on tobacco cessation outcomes: study protocol for a prospective tobacco treatment trial
Authors: Walters Kyle J. , Baker Nathaniel L. , Tomko Rachel L. , Gray Kevin M. , Carpenter Matthew J. , McClure Erin A.
Published: January 2023

Background

Several evidence-based tobacco cessation treatment strategies exist, though significant barriers to cessation remain which must be addressed to improve abstinence rates for sub-populations of those smoking cigarettes. Cannabis co-use among those who use tobacco is common and appears to be increasing among adults in the United States (US). The literature evaluating the impact of cannabis use on tobacco cessation has been mixed and has several important limitations, which precludes development of treatment recommendations specific to individuals who use tobacco and co-use cannabis. To date, no prospective studies have evaluated the impact of cannabis use and severity on tobacco cessation or quantified cannabis use changes during tobacco treatment to assess for concurrent reductions, abstinence, or compensatory (i.e., increased) cannabis use. This study’s aims are to: (1) evaluate tobacco cessation outcomes among participants who co-use cannabis compared to participants only using tobacco, (2) using daily diaries and biochemical verification, assess changes in cannabis use during tobacco treatment, and (3) assess for a dose-dependent impact of cannabis use on tobacco cessation.

Method

A multi-site, prospective, quasi-experimental 12-week tobacco treatment trial enrolling treatment-seeking adults (ages 18–40; N = 208) from three sites across South Carolina (US) who use tobacco daily and oversampling (2:1) those who co-use cannabis. Participants receive tobacco cessation pharmacotherapy (varenicline) paired with behavioral support, while cannabis use is not addressed as part of treatment. The primary outcome is 7-day point prevalence tobacco abstinence at the week 12 end of treatment visit, measured via biochemical verification and self-report. Secondary outcome measures include changes in cannabis use (via biochemical verification and self-report) during tobacco cessation treatment.

Discussion

Results from this trial have the potential to inform tobacco treatment among those co-using cannabis, which may require a tailored approach to address the role of cannabis in quitting tobacco.

Trial registration

The trial is registered with ClinicalTrials.gov: NCT04228965. January 14th, 2020.
Is There Evidence for the Development of Sex-Specific Guidelines for Ultramarathon Coaches and Athletes? A Systematic Review
Authors: Kelly Claudia P. M. G.
Published: January 2023

Background

There is evidence of sex differences in the physiology of endurance exercise, yet most of the advice and guidelines on training, racing, nutrition, and recovery for ultramarathons are based on research that has largely excluded female athletes. The objective was therefore to review the current knowledge of sex differences in ultramarathon runners and determine if sufficient evidence exists for providing separate guidelines for males and females.

Methods

This systematic review was carried out in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Three databases were searched for studies investigating differences in elite and recreational male and female ultramarathon runners. Studies were included if they compared males and females and looked at outcomes relating to the performance or health of ultramarathon runners. The quality of the included studies was determined using the Grading of Recommendations Assessment Development and Evaluation (GRADE) approach.

Results

The search strategy identified 45 studies that met the inclusion criteria. Most studies were observational in design, with only three papers based on randomised controlled trials. The overall quality of the evidence was low. Sex differences in the predictors of ultramarathon performance; physiological responses to training, racing, and recovery; chronic and acute health issues; and pacing strategies were found. There were areas with contradictory findings, and very few studies examined specific interventions.

Conclusion

The results from this review suggest that the development of sex-specific guidelines for ultramarathon coaches and athletes could have a significant effect on the performance and health of female runners. At present, there is insufficient high-quality evidence on which to formulate these guidelines, and further research is required.
Predictive digital twin for offshore wind farms
Authors: Haghshenas Amirashkan , Hasan Agus , Osen Ottar , Mikalsen Egil Tennfjord
Published: January 2023

As wind turbines continue to grow in size, they are increasingly being deployed offshore. This causes operation and maintenance of wind turbines becoming more challenging. Digitalization is a key enabling technology to manage wind farms in hostile environments and potentially increasing safety and reducing operational and maintenance costs. Digital infrastructure based on Industry 4.0 concept, such as digital twin, enables data collection, visualization, and analysis of wind power analytic at either individual turbine or wind farm level. In this paper, the concept of predictive digital twin for wind farm applications is introduced and demonstrated. To this end, a digital twin platform based on Unity3D for visualization and OPC Unified Architecture (OPC-UA) for data communication is developed. The platform is completed with the Prophet prediction algorithm to detect potential failure of wind turbine components in the near future and presented in augmented reality to enhance user experience. The presentation is intuitive and easy to use. The limitations of the platform include a lack of support for specific features like electronic signature, enhanced failover, and historical data sources. Simulation results based on the Hywind Tampen floating wind farm configuration show our proposed platform has promising potentials for offshore wind farm applications.
Effect of visual distraction on discomfort score during flexible fiberoptic direct laryngoscopy: a randomized control trial
Authors: Pyarali Maheen , Aslam Afshan , Nawaz Ahmed , Akhtar Saeed , Andleeb Hira , Syed Dania
Published: January 2023

Background

Flexible fiberoptic direct laryngoscopy is the standard technique for evaluating the larynx and hypopharynx and is a routine outpatient procedure performed in ENT. This study aims to find the effect of patients’ own procedure video as a distractor over the discomfort score, during flexible fiberoptic direct laryngoscopy. It can be a cost-effective alternative to local anesthetics and should be included in our routine practice.

Results

The study included 60 patients undergoing flexible laryngoscopy at a tertiary care hospital. Patients were divided into two groups: group A (those patients who had visualized their procedure video while performing FFODL) and group B (those patients who had not visualized their procedure video while performing FFODL). Visual distraction was involving patients to see their own video while FFODL was being performed. After, the procedure discomfort score was assessed using a visual analog scale. In our study, both groups were comparable in terms of age and gender. The mean discomfort score was significantly reduced in group A as compared to group B (p value 0.003).

Conclusion

This study has shown that visual distraction significantly reduced the procedure-specific mean discomfort scores and that it should be practiced routinely to alleviate patient’s anxiousness and fear to go through this procedure and to gain the confidence of patients.
The United Auto Workers’ Jimmy Hoffa: The Backstory to the Current Corruption Scandal
Authors: Witwer David
Published: January 2023

Richard Gosser was a national leader in the United Auto Workers (UAW) union and a contemporary of James R. Hoffa. Both men had similar backgrounds, had similar ties to organized crime, and faced similar allegations of corruption, but the results of those allegations differed dramatically. Hoffa was singled out by a congressional investigative committee, and his name became a byword for the menace of labor racketeering. After an initial period of controversy, Gosser enjoyed a reputation as a labor statesman. A comparison of their careers highlights the political nature of union corruption probes. Gosser's career also provides a historical perspective on the sources of the recent corruption scandals that have shaken the UAW.
Liver and Renal Injury with Remdesivir treatment in SARS-CoV-2 Patients
Authors: Rabiah Sadaf  , Ali Faiza Sadaqat , Rasheed Tazeen , Bader Faiyaz Zuberi
Published: January 2023

Objective: To determine the effect of Remdesivir on liver enzymes and renal functions in SARS-CoV-2 patients.

Methods: This prospective cohort study was conducted at Dr. Ruth KM Pfau, Civil Hospital Karachi between 1st December 2021 to 31st January, 2022. All patients of severe SARS-CoV-2 infection who received Inj. Remdesivir for five days as per protocol of SARS-CoV-2 management were included. Biodata of selected patients including age, gender, diabetic, hypertensive status was recorded. Patients Liver Function Tests and Serum Creatinine were performed on days 0, 3, 5, 7 and 14.

Results: This study included 85 patients, out of which 55 (64.7%) were males and 30 (35.3%) were females. Out of 85 patients, Remdesivir was stopped in 3 (3.5%) patients. Among these three patients Remdesivir was stopped in one patient on day three because of decrease in CrCl to <30 ml/min. His CrCl improved after stopping Remdesivir. In the remaining two patients, Remdesivir was stopped due to increase in ALT to greater than 10 times from normal values on day three. Similarly, in these two patients the ALT improved after stopping Remdesivir.

Conclusion: Only three patients developed adverse effects resulting in stopping of Remdesivir, however these were reversible on stopping the drug. Therefore, Remdesivir is a relatively safe drug and well tolerated in SARS-CoV-2 patients.

doi: https://doi.org/10.12669/pjms.39.2.6236

How to cite this: Sadaf R, Ali FS, Rasheed T, Zuberi BF. Liver and Renal Injury with Remdesivir Treatment in SARS-CoV-2 Patients. Pak J Med Sci. 2023;39(2):---------. doi: https://doi.org/10.12669/pjms.39.2.6236

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Efficacy of Adjunctive Chlorhexidine in non-surgical treatment of Peri-Implantitis/Peri-Implant Mucositis: An updated systematic review and meta-analysis
Authors: Ye Mingfu , Liu Wenjun , Cheng Shaolong , Yan Lihui
Published: January 2023

Objective: The current review aimed to assess the efficacy of adjunctive chlorhexidine (CHX) in the non-surgical treatment of peri-implantitis/peri-implant mucositis.

Methods: PubMed, Embase, Science Direct, CENTRAL, and Google Scholar databases were searched up to 10th March 2022 for relevant randomized controlled trials or controlled clinical trials.

Results: Fourteen studies were included. Meta-analysis revealed significantly lower probing depths in peri-implant mucositis patients using CHX adjuncts as compared to controls (SMD: -1.49 95% CI: -2.56, -0.42 I2=95% p=0.006). However, the same effect was not noted in peri-implantitis (SMD: -1.18 95% CI: -0.04, 2.40 I2=96% p=0.06). CHX was not found to improve bleeding of probing in peri-implant mucositis while sufficient data was unavailable for peri-implantitis. Results on other outcome variables were conflicting.

Conclusion: Evidence on the efficacy of adjunctive CHX for peri-implant mucositis is conflicting. Similarly, strong conclusions on the effect of CHX for peri-implantitis cannot be drawn due to limited number of studies. Overall, there seems to be a trend of non-significant impact of CHX on outcomes of peri-implant mucositis as well as peri-implantitis.

doi: https://doi.org/10.12669/pjms.39.2.7253

How to cite this: Ye M, Liu W, Cheng S, Yan L. Efficacy of Adjunctive Chlorhexidine in non-surgical treatment of Peri-Implantitis/Peri-Implant Mucositis: An updated systematic review and meta-analysis. Pak J Med Sci. 2023;39(2):---------. doi: https://doi.org/10.12669/pjms.39.2.7253

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Towards the engagement of citizens in SOSTs decision-making: participatory models setting a common ground for border surveillance and respect of fundamental rights. Findings from ARESIBO H2020 project
Authors: Laterza Riccardo , Del Bianco Daniele , Velea Ramona , Ferrari Olivia , De Sabbata Lorenzo , Benedetti Ezio
Published: January 2023

ARESIBO is an H2020 project aiming to improve the efficiency of border surveillance systems by providing the operational teams, as well as the tactical command and control level with accurate and comprehensive information related to border control by different perspectives. Human Rights Groups’ (HRGs) and Civil Society Organisations’ (CSOs) involvement and participation in decision making related Surveillance-Oriented Security Technologies (SOSTs) for border surveillance is considered as a key-factor to ensure the coexistence of two only apparently opposite needs: security and respect of fundamental rights (i.e., privacy, refugees etc.). Starting from this general approach, the paper represents the second part of a research diptych dedicated to present the main achievements and methods proposed by ARESIBO to enhance participation in border surveillance. It outlines the ARESIBO Participatory Model (APM) as a tool to improve HRGs, CSOs, and ultimately citizens’ involvement related to border surveillance in general and the adoption of specific SOSTs for borders’ control. The first part of the paper introduces some key elements included in the ARESIBO desk research that led to the elaboration of the APM (i.e., literature review, semantic analysis), describing who were the targets of that approach (i.e., stakeholders, end-users, actors). After a contextualization on the three interlaced dimensions of surveillance, security and privacy related borders’ control, the paper presents the three components of the methodological framework within which this citizens’ involvement process has been developed (i.e., ARESIBO Participation Framework, ARESIBO Participation Strategy, ARESIBO Participation Action Plan). In the conclusions, by outlining the first partial application of the model within the ARESIBO framework, the paper argues that APM can represent a pilot for a more structured and duplicable participatory model, also through additional research regarding participatory models applied to SOSTs development processes.
Alliteration and Rhyme in the Traditional Kakataibo Chants of Emilio Estrella
Authors: Prieto Mendoza Alejandro Augusto
Published: January 2023

This paper studies alliteration and rhyme in the traditional Kakataibo chants of Emilio Estrella Logía, one of the most important Kakataibo sabios of the present era. For alliteration and rhyme, consonants which are able to be in coda position according to Kakataibo syllable structure play a central role. Alliteration is sporadic and based on the repetition of fricative consonants in passages of indeterminate length. It occurs in syllable onset and freely within a line and across lines, the latter by adjacency. Kakataibo rhyme is also sporadic, its domain is the final syllable of the line and the nucleus of it; only the nasal consonant /n/ can occupy coda in end-line syllables. Kakataibo true rhyme, as opposed to rhyme in lists created by repetition or semantic parallelism, is by adjacency and within vowel passages of indeterminate length.
The Meter of the Ophni and Phineas Insertion in Piers Plowman
Authors: Weiskott Eric
Published: January 2023

The C version of Piers Plowman has yet to earn much attention from metrists relative to the outgrowth of research into fourteenth-century alliterative meter since 1986. Langland’s relationship to metrical tradition is idiosyncratic, a judgment that involves both this author’s divergence from conventions characteristic of other alliterative poems and the recognizability of his own metrical habitus across his career. Scansion of an inconsistently alliterating passage new in C (Prol.95–124) illustrates in miniature the unusual problems thrown up by Langland’s metrical practice and suggests that his metrical signature persisted over the years of his writing life. The Ophni and Phineas insertion is of special interest because it has been thought an unfinished draft.
Zaciąganie zobowiązań gminy w ramach przejściowego deficytu budżetu jednostki samorządu terytorialnego
Authors: Myć Piotr
Published: January 2023

W inicjatywy podejmowane przez gminy jako jednostki sektora finansów publicznych wpisane jest zaciąganie zobowiązań finansowych. Jest to odzwierciedlone w systemowych rozwiązaniach określonych w ustawie z dnia 8 marca 1990 r. o samorządzie gminnym, ustawie z 27 sierpnia 2009 r. o finansach publicznych, czy też ustawie z 17 grudnia 2004 r. o odpowiedzialności za naruszenie dyscypliny finansów publicznych. Za ciekawy obszar badawczy należy przyjąć ustalenie, czy w działaniach omawianych jednostek samorządu terytorialnego pojawiają się pewne obszary, które można uznać za przejaw dysfunkcji, tzn. czy aktywności te są poprawne normatywnie. Ze względu na wytyczony w tytule zakres przedmiotowych analiz rozważane zagadnienia ograniczone zostaną do przejściowego deficytu tej jednostki. Na analizowany problem należy spojrzeć wieloaspektowo, gdyż jego konsekwencje poza – co oczywiste – wpływem na gospodarkę finansową gminy, wpływają również bezpośrednio na społeczność lokalną, tj. m.in. skutkuje zmniejszeniem środków na realizację zadań służących lokalnym społecznościom, ujmowanych w ramach funduszy sołeckich. Zatem należy nie tylko rozważyć instytucję przejściowego deficytu budżetowego gminy, ale także nadać tej instytucji sztywniejsze ramy. We wnioskach końcowych stwierdzono, że zobowiązania zaciągane w ramach przejściowego deficytu budżetowego mają ograniczenia, przede wszystkim muszą być to zobowiązania, które spełniają kryterium przejściowego braku środków na pokrycie określonego zobowiązania, a wspomniane zobowiązanie musi wynikać z uchwały budżetowej. Nadto przekroczenie upoważnienia rady gminy dla zaciągania zobowiązań w ramach przejściowego deficytu budżetowego stanowi naruszenie dyscypliny finansów publicznych.
Kształcenie korespondencyjne jako metoda kształcenia – w okresie jej rozkwitu i upowszechniania
Authors: Woźnicka Elżbieta
Published: January 2023

Założeniem niniejszego artykułu jest zaprezentowanie kształcenia korespondencyjnego jako metody pracy samokształceniowej, której cechą specyficzną jest pośredni, korespondencyjny kontakt nauczyciela z uczniem. Istnieje kilka odmian metodycznych, które są przedmiotem poniższego artykułu: ich wspólną cechę stanowi wspomniany wyżej specyficzny sposób kontaktowania się. Artykuł dotyczy głównie lat 50.–70. XX w. Był to czas intensywnego rozwoju tej formy edukacji dorosłych nie tylko w Polsce, ale również za granicą. Jednocześnie tekst jest próbą ukazania znaczenia kształcenia korespondencyjnego w rozwoju dzisiejszej edukacji na odległość. Z prezentacji rozwiązań metodycznych i dydaktycznych pierwszych szkół korespondencyjnych można wywnioskować, że podstawy metodyki nauczania edukacji na odległość zostały ukształtowane właśnie w pierwszych szkołach korespondencyjnych i są aktualne po dzień dzisiejszy,
Research roundup
Authors: Welyczko Nikki
Published: January 2023

In this section, Nikki Welyczko presents a brief synopsis of a range of recently published articles that may be of interest to nurses working in the renal setting. The aim of this roundup is to provide an overview, rather than a detailed summary and critique, of the research papers selected. Should you wish to look at any of the papers in more detail, a full reference is provided.
EL PODER DE LA ROPA EN ORLANDO DE VIRGINIA WOOLF
Authors: Gutiérrez Gutiérrez José Ismael
Published: January 2023

El presente artículo revisita un aspecto central en muchas de las investigaciones sobre Orlando (1928), la novela de Virginia Woolf (1882-1941): el análisis del juego vestimentario en el que participa su protagonista a lo largo de más de tres siglos y la singularidad identitaria adquirida por sus constantes mutaciones de género, sus cambios de ropa y sus circunstancias particulares. Partiendo de la idea de que los vestidos influyen en la materialidad del sujeto, en su psicología y en la adquisición de una determinada idiosincrasia, este estudio proporciona una relectura del poliédrico recurso de la ropa en la novela de Woolf con el fin de resaltar la modernidad de la propuesta literaria de la escritora y describir el proceso constructivo de una personalidad híbrida que se va labrando histórica y espacialmente. Más allá de la aparente transexualidad y de los travestismos del personaje, en Orlando prevale la opción de la androginia como utopía de una existencia que lucha por eludir la tradicional dicotomía sexogenérica y que es seña distintiva de todo escritor y de un sector importante de la moda de nuestra época.
Objetivos de Desarrollo Sostenible y Acción Social. Una experiencia de incorporación de ODS en la planificación estratégica de una entidad sin ánimo de lucro.
Authors: Esteban Romaní Laura , Vázquez Gómez Lucía
Published: January 2023

La agenda 2030 es considerada el mayor acuerdo internacional para la sostenibilidad del planeta adoptado hasta la fecha. Establece 17 Objetivos de Desarrollo Sostenible para alcanzar la prosperidad social, económica y ambiental. El presente artículo expone una experiencia de cómo se pueden identificar e implementar estos Objetivos en la estrategia de una entidad sin ánimo de lucro como la Federación Española de Fibrosis Quística y sus asociaciones. Para ello, se ha apostado por utilizar la aplicación de metodologías participativas para la investigación-intervención social lideradas desde el Trabajo Social. Se han seguido los 5 pasos recomendados por la Red Española del Pacto Mundial y la Plataforma de ONG de Acción Social. Como resultado se han identificado las prioridades en las que se alinean los diferentes ODS y la estrategia de las entidades. Además, se ha explorado la posibilidad de ampliar estos, no solo a los proyectos derivados directamente de la misión de las entidades, sino también a su ecosistema.
Panorámica de la violencia contra las mujeres con discapacidad en España. Un análisis de datos estadísticos.
Authors: López-Pérez Mercedes
Published: January 2023

La violencia contra las mujeres es el resultado de un sistema de poder que discrimina a la mujer por el hecho de serlo. En las últimas décadas, las mujeres han ocupado el espacio público y han reivindicado sus derechos, haciendo que la sociedad tome conciencia de la gravedad que representa la violencia contra las mujeres. Pero ¿dónde están las mujeres con discapacidad? Estos avances no se reflejan en este grupo especialmente vulnerable. El objetivo de este trabajo es analizar la violencia que soportan las mujeres con discapacidad de 16 o más años residentes en España desde el año 2006 al 2019. Se ha realizado una recopilación y extracción de los datos secundarios proporcionados por las Macroencuestas de Violencia contra la Mujer de los años mencionados y un análisis estadístico descriptivo. Algunos de los resultados obtenidos muestran que la mayoría de estas mujeres, aunque sufren niveles muy altos de violencia, no denuncian, lo que provoca que soporten mayores niveles de fragilidad.
Heritage Interpretation and the Portrayal of Gadara for Tourism
Authors: Alobiedat Ammar A
Published: January 2023

Heritage interpretation is a powerful issue in destination promotion that could either bolster understanding the value of heritage and increase cultural exchange or lead to heritage manipulation to fit political and economic agendas. Using the heritage site of Gadara in northwest Jordan, this article not only examines Gadara’s heritage interpretation and portrayal in the tourism industry, but also presents a holistic approach to Heritage Studies that fosters the inclusion of all types of heritage resources in congruence with the local context. This approach will diversify the attractiveness of heritage assets to meet the needs of different visitors and enhance the quality of their experiences.
Swem: The Tangible and Intangible Cultural Heritage of the Tiv of Central Nigeria
Authors: Nomishan Terngu Sylvanus
Published: January 2023

The Tiv are a major ethnic group in the Middle Belt Region of Nigeria. Scholarly writings about the Tiv usually make mention of Swem as either the ‘ancestral home’ of the Tiv, or an ‘Oath of justice’ sworn by the Tiv people to prove innocence and cleanse the land to avert calamities. To this end, ‘Swem’ stands as a tangible and intangible heritage of the Tiv. This paper examines the nexus between the Tiv and the Swem, and its impact on the culture and traditions of the Tiv people. Data for this research was elicited from primary sources such as oral traditions, and ethnographic survey. Secondary sources such as published books, journals, and monographs were also used in this study. Today, though the Swem tradition is significant in the cultural history of the Tiv people, it is fast going into extinction. Thus, this paper becomes timely and most appropriate for the documentation of the Swem tradition, being part of the cultural heritage of the Tiv people. This documentation will enable a scholarly preservation of the tradition for posterity.
COVID-19 impact on tourism: Measuring similarities and differences on tourists and tourism businesses’ perceptions
Authors: Zouni Georgia , Nasiou Paraskevi-Myrsini , Georgaki Ioanna , Kapetanaki Eirini
Published: January 2023

The purpose of this study is to investigate the similarities and differences between tourists and tourism professionals in Greece in relation to: (a) the impact of the pandemic to tourism, (b) the attitude towards global and national measures, and (c) the behavior of tourists in the next phases of the pandemic and post-pandemic times. A research framework was constructed and tested in two waves, during and after lockdown in Greece. Results highlight that the views of tourism businesses and tourists largely converge, following a more pessimistic or a more realistic approach as time goes by and the pandemic continues.
Gazing upon a fictional ghost town: Juan Rulfo’s Comala and the convergence of dark tourism and literary tourism.
Authors: Speakman Mark , Diaz Garay Alejandro
Published: January 2023

Overlooking the town of San Gabriel in Mexico stands a monument which attracts aficionados of Juan Rulfo’s novel Pedro Paramo. San Gabriel inspired the creation of the fictional Comala, a deserted town haunted by past residents. The main objective of the paper was to explore, from the conceptual perspective of lieux de imagination (Reijnders, 2011) whether some aficionados imagine that San Gabriel is Comala. Furthermore, considering the dark characteristics of Comala, the possibility that specific visitors undergo thanatopsis was also considered. A qualitative approach to the research was deemed the appropriate methodology to answer the research questions and accomplish the overall aim, hence twenty semi-structured interviews were conducted over the course of two days at the monument. The findings demonstrated that all of the participants were attracted to San Gabriel (and the monument) because it was the childhood home of Rulfo and the inspiration for Comala, while the vast majority imagined that San Gabriel transformed into Comala. Meanwhile, a smaller but significant proportion of visitors underwent a thanatological experience. It was suggested that this experience was an example of Debordian dark tourism, hence signifying that the monument is a place in which literary tourism and dark tourism occasionally converge.
A dark literary tourist at the end of life: Tezer Özlü
Authors: Çevik Samet
Published: January 2023

The blending of dark tourism and literary tourism has created a sub-niche as dark literary tourism. It offers dissimilar experiences as it incorporates distinctive motivations from literary tourism and dark tourism. This study aims to provide a better understanding of dark literary tourism motivations and experiences by offering a perspective on the concept of dark literary tourism. For that purpose, the work Journey to the End of Life by Turkish author Tezer Özlü, in which she traced three authors, Franz Kafka, Italo Svevo, and Cesare Pavese, was selected. The work was subjected to qualitative textual analysis. As a result of the analysis, the data obtained on the concept of dark literary tourism were interpreted under three headings. The findings of the study show that dark literary tourists have both dark tourist and literary pilgrim motivations, travelling for motivations such as paying homage to authors and the past, understanding their feelings by establishing closeness and connection with the authors, empathizing with their suffering, acquiring the smallest details about their lives, and experiencing their daily lives. The most crucial finding of the study is that the dark literary tourism experience allows tourists an inner journey and provides awareness about their lives.
Femtosecond laser-plasma dynamics study by a time-resolved Mach–Zehnder-like interferometer
Authors: Zuffi Armando Valter Felicio , Ricardo dos Santos Jhonatha , Maldonado Edison Puig , Vieira Nilson Dias , Samad Ricardo Elgul
Published: January 2023

Side-view density profiles of a laser-induced plasma were measured by a home-built, time-resolved, Mach–Zehnder-like interferometer. Due to the pump-probe femtosecond resolution of the measurements, the plasma dynamics was observed, along with the pump pulse propagation. The effects of impact ionization and recombination were evidenced during the plasma evolution up to hundreds of picoseconds. This measurement system will integrate our laboratory infrastructure as a key tool for diagnosing gas targets and laser-target interaction in laser wakefield acceleration experiments.
Compact on-chip crystalline resonator integration with etching of tapered fiber waveguide
Authors: Yue Jun , Rong Jiamin , Xing Enbo , Xu Weikang , Bai Jiamin , Liu Wenyao , Tang Jun , Liu Jun
Published: January 2023

Whispering-gallery-mode crystalline resonators currently maintain the best quality factor (

Q

) record; however, compact on-chip packaging is still a challenge, although various coupling architectures have been developed. Here, a chemical etching method is proposed to fabricate a miniaturized tapered fiber waveguide on silicon substrate. The Marangoni effect is implemented to reduce the surface roughness of the cone region. The optical loss of 0.1 dB/mm is obtained, and the

Q

of the on-chip crystalline resonator exceeds

1

0

8

. Additionally, thermoelectric cooler (TEC) is implanted in the package to actively customize the temperature, and the temperature response of 18 pm/°C is consistent with the theoretical calculation.
Laser-induced controllable crystallization of organic-inorganic hybrid perovskites assisted by gold nanoislands
Authors: Chen Junying , Yang Jiaxin , Zhuang Weijie , He Xiaobing , Li Shulei , Lin Zhenxu , Lan Sheng
Published: January 2023

Organic-inorganic hybrid perovskites have attracted great interest in recent years because of their excellent luminescence properties. However, the controllable and reversible growth of such perovskites by using a simple method remains a big challenge although it is highly desirable. Here, we demonstrate the controllable and reversible crystallization of MAPbBr3 in a thin liquid film on top of densely-packed gold (Au) nanoislands deposited on a silica substrate. The formation of MAPbBr3 crystal is induced by irradiating densely-packed Au nanoislands with femtosecond laser light. MAPbBr3 crystals with diameters of ∼10 µm can be stably created around the focal point of the laser beam and they will disappear rapidly after switching off the laser light. The threshold laser power for creating stable MAPbBr3 crystal depends strongly on the morphology of Au nanoislands, which can be modified by changing the sputtering time. By increasing the concentration of the precursors in the liquid film, high-quality MAPbBr3 microrods can be obtained after switching off the laser light. Our findings indicate a simple but effective method to induce perovskites with a controllable manner and pave the way for developing photonic devices based on organic-inorganic perovskites.
Dysprosium gain-switched fiber laser at 3.24 µm pumped at 1064 nm
Authors: Jobin Frédéric , Aydin Yiğit Ozan , Bernier Martin , Vallée Réal
Published: January 2023

We report a dysprosium-doped gain switched fluoride fiber laser pumped at 1064 nm and emitting at 3244 nm. Pulses with energies up to 1  µJ were generated on a wide range of repetition rates between 100 kHz and 200 kHz, the highest reported for a pulsed dysprosium-doped fiber laser, producing an average output power reaching 207 mW. Stable 8.9  µJ pulses were also generated near 10 kHz, which is the highest pulse energy reported to date from a 1.1 µm band pumped dysprosium-doped fiber laser. This shows the 1.1 µm band as a valuable alternative for the pumping of dysprosium-doped fiber lasers emitting far from the emission peak and is thus of potential interest for future field applications.
Myopic axial elongation in school children and the COVID-19 lockdown in Russia: The Ural Children Myopia Study
Authors: Bikbov Mukharram M. , Kazakbaeva Gyulli M. , Fakhretdinova Albina A. , Tuliakova Azaliia M. , Rakhimova Ellina M. , Panda-Jonas Songhomitra , Gilemzianova Leisan I. , Garipova Liana A. , Khakimov Dinar A. , Jonas Jost B.
Published: January 2023

Background

To explore an influence of the COVID-19-related lockdown on ocular axial elongation in school children in Russia.

Methods

The participants of the school-based Ufa Children Myopia Study in Ufa/Russia underwent, at baseline in 2019/2020 before the COVID-19 outbreak and after a COVID-19-related lockdown, a detailed interview and ophthalmological examination including laser interferometric biometry for axial length measurement.

Results

The study included 461 children (age:10.7±2.1 years;range:6.8–16.9 years). The mean follow-up was 1.41±0.33 years. Mean axial length at baseline was 23.96±0.95mm and 23.94±0.95mm in the right and left eyes, respectively. During the study period, annual axial elongation (right/left eyes) was 0.19±0.17mm/0.19±0.22mm. Before the COVID-19 lockdown, the age-dependent coefficient for axial length (ADCAL) for the right/left eyes was 0.21mm (95%CI:0.17,0.25)/0.20mm (95%CI:0.16,0.24). In children younger than 9.6 years (n = 157), annual axial elongation (right eyes) during the study period was larger than the ADCAL before the COVID-19 outbreak (0.29 mm (95%:0.00,0.66) versus 0.21 mm (95%CI:0.02,0.41)). In the groups aged 9.6 to 11.4 years (n = 148) and aged >11.4 years (n = 156), annual axial elongation during the study period was comparable to the ADCAL before the COVID-19 outbreak (0.18mm (95%CI:-0.07,0.46) versus 0.22mm (95%CI:-0.05,0.48), and (0.09mm (95%CI:-0.15,0.34) versus 0.14mm (95%CI:0.00,0.28), respectively). In children aged ≤9 years at study end, axial length at study end was 0.20 mm larger than axial length at baseline in the participants aged ≤9 years at baseline. Larger axial elongation during the study period was associated (multivariable analysis) with younger age (beta:-0.62;P<0.001), female sex (beta:0.21;P<0.001), longer study period (beta:0.22;P<0.001), and longer axial length at baseline (beta:0.28;P<0.001), and marginally, with less time spent outdoors (beta:-0.07;P = 0.06).

Conclusions

The COVID-19-related lockdown in the Russian city of Ufa was associated with a relatively minor increase in axial elongation, detected only in children aged <9.6 years.
Problematic smartphone and social media use among undergraduate students during the COVID-19 pandemic: In the case of southern Ethiopia universities
Authors: Mengistu Nebiyu , Habtamu Endashaw , Kassaw Chalachaw , Madoro Derebe , Molla Wondwosen , Wudneh Aregahegn , Abebe Lulu , Duko Bereket
Published: January 2023

Background

Smartphone and social media use are supposed to be integral parts of university students’ daily lives. More specifically, smartphones and social media are frequently used for communication in daily life during the COVID-19 pandemic. Nonetheless, uninterrupted and persistent use of these technologies may lead to several psychological problems. Even though smartphones and social media were used more frequently during the pandemic, there is no evidence suggesting that the studies were not undertaken in low-income countries, including Ethiopia. Therefore, the current study aimed to assess problematic smartphone use and social media use among undergraduate university students in southern Ethiopia.

Methods

A cross-sectional study was carried out among 1,232 university students using a simple random sampling technique. The Bergen Social Media Addiction Scale and Smartphone Application-Based Addiction Scale were used to collect data on social media and smartphone use, respectively. The Beck Depression Inventory, Generalized Anxiety Assessment Tool, Rosenberg Self-Esteem Scale, and Pittsburg Sleep Quality Index were standardized tools used to measure other independent variables. To identify factors, simple and multiple linear regression analyses were performed. A p-value of 0.05 was used to determine statistical significance.

Results

The overall response rate was 95%. The mean scores for problematic smartphone and problematic social media use were 17 ± 3.3/36 and 12.7 ± 2.2/30, respectively. A linear regression model revealed that being female, first-year students and poor sleep quality were significantly associated with problematic smartphone use. Factors associated with problematic social media use (PSMU) were depression, substance use, and urban residence.

Conclusions

This study identified significant problems with smartphone and social media use among university students. Therefore, it is preferable to provide psychological counselling, educate students about safe, beneficial, and healthy internet use, and focus on recognized high-risk groups in order to give them special attention. It is also preferable to seek counselling about substance use. It is preferable to regularly screen and treat individuals with psychological problems in collaboration with stakeholders.
Leveraging an advanced simulated moving bed approach to achieve 3-component separation for enhanced impurity removal in a non-affinity cation exchange capture step
Authors: Chen Serene W. , Zheng Zi Ying , Mahfut Farouq Bin , Yang Yuansheng , Ogino Masahiro , Okada Kazuo , Sato Kohei , Zhang Wei
Published: January 2023

One of the key challenges in downstream bioprocessing is to obtain products of high purity in a productive fashion through the effective removal of process and product related impurities. While a classical simulated moving bed (SMB) system operation can typically achieve a 2-component separation between the weakly bound impurities and target species, here we present an advanced SMB approach that can achieve a 3-component separation, including the removal of the strongly bound impurities from the target species. As a proof-of-concept, we demonstrate the enhanced removal of strongly bound host cell proteins (HCP) from the target monoclonal antibody (mAb) through the utilisation of the advanced SMB approach in a non-affinity cation exchange (CEX) capture step. In this way, 1 less polishing step was required to achieve the therapeutic requirements of < 100 ppm HCP and the overall process recovery was increased by ~ 6% compared to the corresponding process that utilised a batch CEX operation. The non-affinity CEX capture platform technology established through the utilisation of the advanced SMB approach presented here can potentially be further applied to address the downstream processing challenges presented by other challenging biotherapeutic modalities to yield a final target product with improved purity and recovery.
Farmers’ beliefs and concerns about climate change, and their adaptation behavior to combat climate change in Saudi Arabia
Authors: Azeem Muhammad I. , Alhafi Alotaibi Bader
Published: January 2023

Climate change threatens the existence of humankind on the planet Earth. Owing to its arid climate and poor natural resources base, Saudi Arabia is particularly susceptible to the negative impact of ongoing climate change. Farmers’ understanding of this global phenomenon is extremely important as it may help determine their adaptation behavior. This study was designed to analyze farmers’ beliefs and concerns about climate change as well as their views about adaptation different obstacles. Data were collected from 80 randomly farmers of the Al-Ahsa region in Eastern Province using structured interviews. The findings revealed that farmers believed that climate change is mainly occurring due to anthropogenic activities. Drought, insects, crop diseases, and heat stress were their main concerns regarding adverse impacts of climate change. Lack of knowledge about adaptation practices, and poor government and financial support are perceived as the major obstacles to adaptation. The results of non-parametric analysis identified no significant differences in farmers’ climate change beliefs and concerns, and their views about obstacles to adaptation in relation to their demographic characteristics. Based on the findings, we suggest that capacity building programs should be undertaken by the government for enhancing the adaptive capacity of the farmers as well the provision of financial incentives wherever deemed necessary for promoting the adoption of sustainable agricultural practices and building a resilient national food system.