bluuebunny/crossref_metadata_2025 huggingface dataset:
MD, Doctor of Medical Science, Head of the Department of Pulmonary Hypertension and Heart Diseases, Myasnikov Clinical Cardiology Institute
Authors: Lyapina I. N. , Valieva Z. S. , Martynyuk T. V.
Published: February 2025

The review addresses principal approaches to intensifying therapy in patients with pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH). The position of Russian experts on the strategy of switching within one class of PAH-specific therapy is presented. Particular attention is paid to the strategy of therapy optimization in the form of replacing phosphodiesterase type 5 inhibitors with a stimulator of soluble guanylate cyclase (riociguat) in patients with PAH and inoperable/residual CTEPH who cannot not achieve treatment goals on phosphodiesterase type 5 inhibitors. The authors analyzed and identified the criteria justifying the choice of a specific therapy strategy in favor of switching from a phosphodiesterase type 5 inhibitor to riociguat.
Analysis of keyword networks of electronic scientific journal
Authors: Müller Fernandes Rogerio Paulo , Maria Nogueira Cervantes Brígida , Luiz Contani Miguel
Published: February 2025

Information science faces challenges in addressing the ever-growing, deterritorialized, and increasingly complex digital environment. New methodological approaches are needed to effectively analyze the diversity of contemporary networks and information systems. This study employed bibliometric and network analysis to examine trends and highlight frequent keywords within a scholarly electronic journal, Informação & Informação. The analysis quantitatively and visually mapped the relationships between keyword frequency and co-occurrence within the journal’s corpus. Data, spanning four decades, were grouped and analyzed using keyword network maps. While “information science” emerged as a prominent keyword, its relevance in published research became particularly pronounced in the first decade of the 21st century. The analysis also revealed a considerable expansion of research themes over time, with “knowledge organization,” “knowledge management,” “information management,” and “scientific communication” appearing as particularly relevant topics.
Phenology and production of blackberry trees in the southern Minas Gerais
Authors: Dos Santos Cruz Guilherme , Bortolotti da Silva Adriano , Sampaio de Matos Nágla Maria , Corrêa Landgraf Paulo Roberto , Alves Leão Ana Patrícia
Published: February 2025

The objective of this study was to evaluate the phenology, yield and productivity of “Brazos” and “Tupy” blackberry cultivars in the first production cycle in southern Minas Gerais. The experiment was carried out in a property in the municipality of Serrania – Minas Gerais (MG), with a randomized block design, two cultivars (“Brazos” and “Tupy”), 10 blocks and two useful plants per experimental unit. In the harvest of the 2022/23 production cycle, the beginning, end and duration of flowering were recorded, as well as the beginning, end and duration of the harvest. The following productive parameters were evaluated: number of fruits per plant, fresh fruit mass (g), yield (g plant–1) and estimated productivity (kg ha–1). In mid-November, six fruits per plot were randomly selected to obtain physical fruit parameters (mean lengths and diameters). The data was submitted to analyses of variance and the means were compared using the Tukey test, at 5 % probability. The “Brazos” cultivar had longer flowering and harvest duration. “Tupy” overtook “Brazos” in number of fruits per plant, yield and estimated productivity (p<0.05). “Brazos” produced heavier fruits with a larger diameter (p<0.05). It was concluded that the flowering and harvest duration of the “Brazos” and “Tupy” blackberry cultivars are similar in the first production cycle. During the first production cycle, the “Tupy” cultivar achieved higher production and higher estimated productivity, and the “Brazos” cultivar produced heavier fruits with a larger diameter.
Separate (Asynchronous) Therapeutic Plasma Exchange (TPE) and Plasma Transfusion in the Patient with Severe TPE Complications: A Case Report
Authors: Anvari Saeid , Larijani Amirhossein , Ghorbannejad Nasim
Published: February 2025

Thrombotic thrombocytopenic purpura (TTP) is a medical condition characterized by a decreased activity of the ADAMTS13 protease, which is responsible for cleaving the von Willebrand factor. It contributes to thrombotic microangiopathy. In this report, we described a case of TTP followed by significant adverse effects during therapeutic plasma exchange (TPE) treatment. The patient received TPE with a time interval from plasma transfusion.
A 30-year-old female was evaluated for headaches and bruises on her arms and legs. Laboratory testing revealed thrombocytopenia and anemia. The identification of thrombocytopenia with severe schistocytosis was verified by the analysis of a peripheral blood smear. After confirming a diagnosis of TTP, TPE was performed as therapy. To avoid the complications arising during the previous TPE sessions, we conducted plasma exchange with albumin followed by FFP injection, with a six-hour interval between them. This strategy successfully alleviated the patient's symptoms.
Therapeutic plasma exchange (TPE) with a time interval from plasma transfusion can be successfully used in patients with severe TPE complications.
Different Presentations and Different Treatment Options in Blastic Plasmacytoid Dendritic Cell Neoplasms: A Case Series
Authors: Cengiz Esra , Aydin Muruvvet Seda , Gunes Ahmet K , Ceran Funda , Dagdas Simten , Ozet Gulsum
Published: February 2025

Blastic plasmacytoid dendritic cell neoplasms (BPDCN) are rare, aggressive hematologic neoplasms. Awareness about this neoplasm has increased after it was defined as a clonal plasmacytoid dendritic cell disease under histiocytic/dendritic cell neoplasms in the World Health Organization 2022 classification of myeloid and Histiocytic/Dendritic Neoplasms1. Therapies include chemotherapy or immunotherapy2-4 though stem cell transplantation (SCT) is the best consolidative approach in eligible patients5. Here, we present one intensive therapy-ineligible and two intensive-therapy-eligible patients with different presentations of BPDCN.
Escherichia coli in septic arthritis: prevalence and antibiotics susceptibility patterns
Authors: Ali Khan Masroora , Kamran Taj Muhammad , Khan Zahid , Taj Imran , Naeem Muhammad , Azam Saima
Published: February 2025

Background and Objectives: Septic arthritis (SA) is an orthopedic emergency mainly caused by bacteria. SA due to Esche- richia coli (E. coli) is rare with a poor prognosis. This study aimed to assess the occurrence and antibiotic resistance patterns of E. coli in SA patients in Quetta, Balochistan, Pakistan.
Materials and Methods: A cross-sectional study was conducted from March 2021 to December 2023. 220 samples were collected from SA patients from tertiary care hospitals. Joint aspirates (2ml) and blood (5ml) were analyzed for microbial and hematological examination.
Results: There were 5.45% samples positive, and 94.5% negative for E. coli. SA due to E. coli was more common in male (6.2%) than female (4.6%) patients with the knee being the most affected joint (6.3%). E. coli was more common in patients aged 41-60 years (7.7%), lower socioeconomic (6.9%), and illiterate (8.6%) patients. Suspected patients showed a significant increase in the levels of white blood cells (WBC), C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR), nota- bly, these levels were further elevated in E. coli-positive patients. The polymerase chain reaction (PCR) based identification of E. coli showed clear bands of 204bp of the 16S rRNA gene. Sequence analysis using the Basic Local Alignment Search Tool found high similarity with pathogenic E. coli from Egypt and China. The identified E. coli strain showed significant resistance to common antibiotics: amoxicillin, amoxicillin-clavulanate, ceftriaxone, sulfamethoxazole/trimethoprim, genta- micin, tetracycline, and erythromycin.
Conclusion: Antibiotic resistance in E. coli from SA patients suggests the need for accurate antibiotic selection to ensureprompt treatment.
Direct MALDI-TOF MS-based method for rapid identification of microorganisms and antibiotic susceptibility testing in urine specimens
Authors: Assi Fouad , Jabri Brahim , Melalka Lamia , Sekhsokh Yassine , Zouhdi Mimoun
Published: February 2025

Background and Objectives: Urinary tract infections (UTIs) are considered as a major public health issue, often causing complications. Although the traditional cultivation approach is reliable in diagnosis, it is time-consuming, leading to delay in treatment and contributing to antibiotic resistance due to suboptimal empirical treatments. This study aimed to evaluate the performance of a direct, rapid identification technique using MALDI-TOF MS for pathogen identification and antibiotic susceptibility testing in UTIs, aiming to reduce diagnostic time compared to standard culture methods.
Materials and Methods: In the span of a year, 458 monomicrobial urine samples were analysed using both the standard bacterial culture method and the direct MALDI-TOF MS-based method. Antibiotic susceptibility was directly tested on 20 samples using the disk diffusion method.
Results: The direct identification technique accurately identified 92.14% of microorganisms at the genus level and 60.92% at the species level within an hour, significantly faster than the 24 to 48 hours required by traditional culture methods. The direct antibiotic susceptibility test results were consistent with the standard post-culture method ranging from 60.00% to 100%. Conclusion: Direct identification using MALDI-TOF MS can improve UTI management by enabling faster pathogen iden- tification and targeted treatments, potentially reducing antibiotic resistance. Further studies are needed in terms of enhancing its clinical utility and reliability.
Serological epidemiology analysis of Cytomegalovirus infection in pregnant women in Diwaniyah, Iraq
Authors: Khadhur Al-Zubaidi Mohsen Abdul , Hosseini Seyed Masoud , Al-Roudhan Mohsen Abdul Nemah , Al-Harmooshee Maather Baqer Hussein
Published: February 2025

Background and Objectives: Human cytomegalovirus (HCMV) infection is the most common cause of congenital infection during pregnancy. It is a major concern worldwide with a wide range of clinical outcomes in fetuses and newborns due to HCMV reactivation or reinfection during pregnancy. Primary maternal infection is best diagnosed by examining IgM and IgG antibodies. The current study aimed epidemiology survey of congenital HCMV infection in pregnant women in Diwan- iyah.
Materials and Methods: 600 blood samples were collected from pregnant women, between 18-45 years old, in Diwaniyah Governorate for 12 months, from January to December 2022, in regards to their place of residence (urban or rural). All sam- ples were monitored for both IgG and IgM antibodies against HCMV using rapid test and ELISA.
Results: Our findings showed a high positive rate for IgG (95.7%) and (96.2%) and a positive rate for IgM (1.5%) and (1.8%) for rapid test and ELISA, respectively. The highest IgG positive rate was in the age group 26-35 years (43.33%), while the lowest rate (13.0%) was in the age group 36-45 years. The HCMV infection rate in rural and urban areas were (96.48%) and (95.26%), respectively, with no significant differences (P value>0.05). Also, the rate of miscarriages among pregnant women infected with HCMV was 28.83%, and the highest infection rate (30.51%) was recorded in the age group 26-35 years.
Conclusion: The prevalence of HCMV infection and its related miscarriage among the studied population is relatively high with the highest rate in the age group of 26-35 years.
New Interpretations and Adaptations of Shakespeare’s Plays in Japan from 2020 to 2023
Authors: Kawai Shoichiro
Published: February 2025

This essay examines some notable Shakespearean productions and adaptations in Japan from 2020 to 2023. The main focus is on a Hamlet production by Mansai Nomura, a Kyogen performer, in March 2023; it was an amalgamation of the traditional Japanese theatres, such as Kyogen, Nô, Kabuki, and Bunraku. Mansai’s aspiration to produce Hamlet, utilizing all the elements of traditional Japanese art forms, began twenty years ago, when he played Hamlet in Jonathan Kent’s production in London and in Tokyo. He re-examined the text and offered a completely new interpretation of a scene, giving the play a fresh dimension. Moreover, this essay examines other recent Shakespeare productions and adaptations, including my two new plays based on Shakespeare, as well as Kôki Mitani’s Thirteen Vassals of Kamakura Shogun, a serial historical TV drama, broadcast by NHK (Japan’s version of the BBC).
Assessment of Happy Seeder as a Resource Conservation Technology in Hamirpur District of Uttar Pradesh, India
Authors:   Banda University of Agriculture and Technology, Banda, (U.P.), Shalini Shalini
Published: February 2025

Residue burning in conventional agriculture poses a significant challenge, resulting in the loss of vital plant nutrients and contributing to environmental degradation. To address these issues, it is important to develop feasible, cost-effective, and environmentally friendly technologies. In light of this pressing concern, an on-farm trial was conducted during 2019-20 & 2020-21 to evaluate the performance of happy seeders based on yield and economics, compared to the existing farmer's conventional practice of sowing the wheat crop. The Happy Seeder, a resource-conserving technology for residue management in agricultural systems, has gained significant attention for its potential to improve soil health, reduce the burning of crop residues, and promote sustainable agricultural practices. This study assesses the effectiveness and adoption of the Happy Seeder in Hamirpur District, Uttar Pradesh, India, focusing on its role in resource conservation, cost savings, and productivity enhancement. The study revealed that the average reduction in weed count in happy seeder fields was 33.3% compared to normal sown wheat. Sowing of wheat crops with a happy seeder yielded 5% more over farmer's fields. Happy seeder sown wheat recorded higher net income (Rs. 92454/ha) with B:C ratio of 1:4.4 compared to normal sown wheat i.e. Rs. 80026 /ha with B:C ratio of 1: 3.3.
Development of Alcohol-Tolerant Yeast Strains and Assessment of their Fermentation Efficiency
Authors:   National Sugar Institute, Kanpur, Uttar Pradesh, India, Ranganathan Ananthalakshmi
Published: February 2025

Ethanol consumption rises with urbanization as people seek alternative fuels, industrial solvents, cleaning agents and preservatives. The synthesis of ethanol by Saccharomyces cerevisiae is influenced by a number of intrinsic variables, including fermentation conditions such as temperature, pH, ethanol concentration and sugar concentration. Ethanol is the main result of yeast sugar fermentation under anaerobic conditions. On the other hand, ethanol may inhibit the activity of yeast cells like yeast growth, viability, and fermentation rates. The current study focuses on developing alcohol-tolerant strains by inducing alcohol stress. The developed alcohol-tolerant strains are studied for their morphological and biochemical characteristics and evaluated for their fermentation efficiency. The testing results revealed that all the produced alcohol-tolerant strains were able to grow well at alcohol concentrations of 10%, 12%, 14%, 16%, 18%, and 20%. The examination of developed alcohol-tolerant strains revealed that all the strains are of Saccharomyces cerevisiae and are able to ferment sucrose to ethanol. The fermentation efficiency of control yeasts (CM and CY) was determined to be 93.7%. Alcohol-tolerant strains with 18% and 20% alcohol strength demonstrated fermentation efficiency ranging from 88% to 91%. The alcohol-tolerant strains M4 – molasses-based culture and Y4– YPD-based culture with 16% alcohol strength achieved the highest fermentation efficiency of 98.2% and 98.3%, respectively. The alcohol-tolerant yeast strains - M4 and Y4 could serve as potential strains for fermentation even under high ethanol concentrations and could be used at the industrial level for fermentation of various raw materials in order to increase bioethanol output.
Nutritional Evaluation of Azolla pinnata Meal in Broiler Chicken Diets
Authors: Yassar F.B. , Rano N.B. , Abubakar A.
Published: February 2025

Background: This study was carried out to evaluate the nutritional value of Azolla pinnata meal (AZM) in broiler chickens’ diets. Methods: The experiment was laid in a completely randomized design comprising a total of one hundred and sixty Cobb 500 strain of day-old broiler chicks which were randomly assigned into 4 dietary treatment groups with 4 replications, comprising 10 birds per replicate for a six-week duration. The iso-caloric and iso-nitrogenous diets were tested at 0, 10, 20 and 30% levels of AZM inclusion designated as T1, T2, T3 and T4 respectively. The experimental diets were offered ad libitum throughout the trial. At the end of the feeding trial, one bird per replicate was selected for carcass evaluation. Proximate compositions of AZM and meat samples were determined. Data generated were statistically assessed by Analysis of Variance. Result: Proximate analysis of AZM revealed crude protein, crude fibre, ether extract and total ash values of 22.5, 7.37, 3.59 and 19.46, respectively. Results also showed no significant difference (P greater than 0.05) in live weight gain but, feed intake significantly differed (P less than 0.05) with T1 having the highest value of 2.91kg/bird and T4 recorded the least value of 1.80 kg/bird. The feed conversion ratio was also found to be statistically (P less than 0.05) lower in T4 and highest in T1 group. The inclusion of AZM in the diets did not (P greater than 0.05) influence the carcass and internal organs characteristics except for empty gizzard. However, the crude protein content of broiler meat was improved significantly at T2 10% AZM level.
The Daily Behavior of Bali Cattle (Bos sondaicus) at the Conservation Ex-Situ of PT Taman Satwa Kota Semarang
Authors: Fauziah Gassania Naufal , Kasiyati Kasiyati , Isdadiyanto Sri , Setiawan Hendrik Tri
Published: February 2025

Bali cattle are tropical animals that adapt to environmental changes in an effort to maintain survival. The presence of visitors at the conservation area affects the daily behavior of Bali cattle. The study was aimed to analyze the daily behavior of Bali cattle at the Conservation Ex-situ of PT Taman Satwa Kota Semarang under conditions of weekday and weekend; on weekdays (Monday to Friday) there were fewer visitors, and on weekends (Saturday to Sunday) there were more visitors. This study was conducted for 30 days, and behavior observation using the focal animal sampling method included eating behavior, group tendency behavior (allelomimetic) and avoidance behavior (agonistic), shelter seeking, and eliminative behavior. Cattle were observed for two hours at 10-minute intervals. Data analysis was carried out using the t-test at a significant level of 5%. The results of the study showed that visitor activity caused Bali cattle to tend to reduce their active movement and choose to remain silent away from the enclosure fence. The excitement of visitors on weekdays and weekends had a significant effect (P<0.05) on the duration of eating (foraging), agonistic, and eliminative behaviors, as well as the frequency of allelomimetic and eliminative behaviors. The conclusion of this study was that the elimination and group behavior of Bali cattle in conservation areas occurred more frequently and for longer durations on weekdays as an indicator that the cattle were uncomfortable, so it was necessary to limit visiting time in the cattle pen area, which may improve cattle welfare.
Otros modos de ser/hacer escuela. Sujetos, territorios y disputas desde prácticas educativas otras
Authors:   Universidad Nacional de Río Negro, Brumat Maria Rosa ,   Argentina., Jaimes Garrido Rosa Isabel ,   Universidad Autónoma del Estado de México; México.
Published: February 2025

Este dossier “Otros modos de ser/hacer escuela. Sujetos, territorios y disputas desde prácticas educativas otras” de la Revista Praxis Educativa de la Universidad Nacional de La Pampa, Argentina, tiene por objeto poner en foco educaciones otras o prácticas educativas otras que nos muestran y plantean otros modos de ser y hacer escuela en territorios latinoamericanos (México, Brasil y Argentina). En este sentido, es que se recupera a la praxis como eje en el análisis concreto de las experiencias que componen al dossier porque consideramos que atraviesa los artículos adquiriendo significaciones según las experiencias, contextos y miradas que desarrollan y crean las condiciones para otras formas de pensar y hacer en los procesos educativos.
Learning in the forest: community education and forestry in southern Mexico
Authors:   Universidad Autónoma Benito Juárez de Oaxaca, México, Pérez Rios Edgar
Published: February 2025

La presente contribución tiene como objetivo analizar las prácticas educativas comunitarias en torno al aprovechamiento forestal en el núcleo agrario de San Jerónimo Coatlán, Estado de Oaxaca, en el sur de México. Se trata de procesos educativos fuera del ámbito escolar, lo cual implica que los agentes educativos, tiempos y espacios estén determinados en función de las dinámicas comunitarias. Este es un estudio etnográfico, con perspectiva histórica, que recupera datos de campo recabados durante el ciclo de aprovechamiento forestal que abarcó de febrero a agosto de 2024. Los principales hallazgos muestran que, desde que la comunidad ingresó al mercado forestal, en la década de 1970, ha habido una constante transmisión intergeneracional de conocimientos que, actualmente, les permite tener una autonomía en el manejo del bosque y el territorio. También se pudieron observar diversos procesos de negociación interna, que incluyen tensiones y acuerdos. Un tercer hallazgo se relaciona con aprendizajes forestales de carácter técnico, es decir, con la forma de trabajo en la extracción de madera. Finalmente, se observó que, a partir de estos procesos, la comunidad en cuestión ha construido estrategias de autorregulación en el manejo del bosque y sus recursos maderables. Se concluye que existe un proceso de construcción de autonomía educativa y forestal encaminado hacia la preservación del bosque como espacio que permite el sostenimiento económico y social de la comunidad.
Topical application of a gel formulation containing Centauri® honey enhances epidermal water balance in healthy skin – data from a 28-day pilot trial
Authors: Cariano Lopes Mariana , Rijo Patrícia , Monteiro Rodrigues Luis
Published: February 2025

Honey is one of the oldest natural products applied to human skin. However, science-based evidence of some of its biological impacts are recent. Our study focuses on the impact of topically applied honey on healthy skin. To that purpose, a 28-day exploratory study was designed involving eight healthy participants of both sexes, selected following previously defined criteria. This double-blind study involved two identical formulations, where only one contained 5% (w/v) of a previously characterized honey (Centauri® honey, produced in Turkey). Formulations were applied daily (0.1 mL per application) for twenty-eight days (D0–D28) of regular use. Compliance was regularly verified by the investigators. Measured outcomes were “epidermal” barrier quantified by evaporimetry and epidermal hydration measured by electrometric techniques. Results demonstrated that at the end of the study peroid, the formulation with honey significantly reduced trans-epidermal water loss while improving both superficial and deep hydration of the skin as compared to the respective controls at D0. Similar favorable results were also obtained with the same formulation after a challenge test using tape-stripping. These results confirm the interest of this ingredient in skin health, even in healthy participants, that should be further explored.
Running Spatiotemporal Parameters are Associated with Standing Long Jump Distance and BMI in Children aged 3-10 Years
Authors: Mesquita Paula R. , De David Ana C.ristina
Published: February 2025

Background: Evidence shows that standing long jump (SLJ) distance is related to running velocity in children aged 4-5. However, this hypothesis still requires further investigation and should be tested in a wider age range of the child population. Moreover, increased body mass index (BMI) may affect spatiotemporal parameters, and its impact seems to change with age and different activities such as running, requiring further study.
Aim: We aimed to investigate the associations between running velocity and the SLJ distance in children aged 3-10 years. We also described sex-specific normative values for SLJ. Further, the association between BMI and running and walking spatiotemporal parameters was presented.
Method: This study included 182 children aged 3–10 years. SLJ was measured through standard procedures. We assessed running through the absolute and normalized velocities, cadence, step length, cycle time, and duration of the swing and stance phases using the GAITRite walkway. Participants completed three valid trials for each condition: fast running, self-selected running, and self-selected walking.
Results: The SLJ distance was associated with higher running velocity. Performances on the SLJ test were better for older and male children. Higher BMI led to a reduction of the swing phase, cadence, and velocities.
Interpretation: We suppose that leg muscle power, growth, and motor development enhance running velocity and SLJ distance. Sex differences in the SLJ test were linked to the maturational and morphological characteristics of boys and girls. The effect of a higher BMI on spatiotemporal parameters may be more relevant during running than walking.
Editorial: Manipulation of Sensory Information on Postural Control Performance of Children, Young and Older Adults
Authors: Polastri Paula F. , Godoi-Jacomassi Daniela
Published: February 2025

Effective postural control is essential for daily activities, sports, and fall prevention. It relies on the integration of sensory information from the visual, vestibular, and somatosensory systems, which continuously adapt throughout life. Research in this area explores how altering sensory information impacts balance across different age groups and conditions. This special issue features studies on children, athletes, older adults, and individuals with neurological or developmental disorders, highlighting the complex relationship between sensory input and postural control. Two studies explore the developmental role of sensory systems in balance and investigate visual dependency and fall risk in older adults. Additionally, two studies examine how sensory manipulation affects postural control, particularly in older adults and individuals with balance deficits, such as Parkinson’s disease. One infographic illustrates how hemophilia affects postural and gait performance. Finally, three studies discuss interventions such as physical exercise, neurostimulation (e.g., tDCS), and trunk resistance load, all aimed at improving postural control. By manipulating sensory information, we can gain a deeper understanding of how postural control functions and develop effective strategies to enhance balance, particularly for individuals with specific health conditions or age-related challenges.
A extensão nos estatutos da Universidade Estadual de Campinas
Authors: Oliveira Loryne Viana de
Published: February 2025

Ao longo de seus 56 anos, a Universidade Estadual de Campinas - Unicamp, teve ao menos 29 versões de seu Estatuto. Os Estatutos, baixados pelo Decreto nº 52.255 de 30 de julho de 1969, são documentos que estipulam os fins e constituição da universidade, regimentando sua organização e aspectos administrativos gerais. Considerando o contexto atual de implantação da Resolução 07/2018 do Conselho Nacional de Educação – que estabelece as Diretrizes para a Extensão na Educação Superior Brasileira –, o objetivo da presente pesquisa, de natureza bibliográfica, foi cotejar os sentidos e modelos de Extensão Universitária que comparecem nos Estatutos da Unicamp, considerando suas atualizações ao longo dos anos de sua existência. Acessoriamente, se recorreu aos Relatórios de Gestão da Universidade. Identificou-se a persistência de uma concepção ofertista de extensão universitária - aquela que parte unilateralmente da comunidade de pesquisa para a sociedade - nos primeiros 54 anos da universidade. De 2020 em diante, a letra dos Estatutos muda substancialmente, em resposta à citada Resolução, que torna compulsória a incorporação, de ao menos 10% do total da carga horária curricular estudantil dos cursos de graduação, de atividades de extensão. Assim, os Estatutos passaram a dedicar um título próprio para a extensão em seu texto e incorporaram uma concepção de extensão afeita à Política Nacional de Extensão Universitária, consolidada em 2012 no âmbito do Fórum de Pró-Reitores de Extensão das Instituições Públicas de Educação Superior Brasileiras.
Antropologia no som
Authors: Fleischer Soraya , Manica Daniela Tonelli
Published: February 2025

Neste texto, apresentamos uma prática em extensão universitária. A Antropologia é uma área científica que pouca gente conhece, com um nome estranho e pouca visibilidade pública. O Mundaréu é um podcast de divulgação científica da área de Antropologia. Criado em 2019, este projeto interinstitucional vem investindo em apresentar as formas de pesquisa, de escrita, de debate que a área desenvolve. Aqui, contaremos do projeto a partir dos objetivos da Antropologia, dos desdobramentos do som e da potência das histórias vividas conjuntamente entre antropólogas e suas interlocutoras.
O lugar do direito
Authors: Santos Cleiton Marcolino Isidoro dos
Published: February 2025

Este artigo busca realizar uma crítica a tese da independência proposta por Marcus Willaschek, bem como apresentar uma interpretação do direito e da ética enquanto parte da lei moral na arquitetônica kantiana, denominada aqui por tese da especificidade. Para isso, será apresentado o debate acerca da dicotomia entre a Doutrina do direito (Rechtslehre) e a Doutrina da virtude (Tugendlehre). Após isso, será exposto os argumentos propostos por Willaschek com os quais se realizará a crítica aqui definida. Por fim, pretendemos expor uma outra visão do debate, propondo a tese da especificidade para melhor interpretação do texto kantiano.
Plasma mcfDNA Sequencing May Improve Usual Care Diagnostics to Detect HHV-8 Among Outpatient People with Advanced HIV
Authors: Park Sarah , Epling Brian , Richey Morgan , Lupu Daniel , Mughar Mona , Sereti Irini
Published: February 2025

Background: Human herpesvirus-8 (HHV-8), or Kaposi sarcoma (KS)-associated herpesvirus (KSHV), causes severe disease in people with profound immunosuppression. Yet, diagnosing KS can be challenging given the diverse manifestations and current limited usual care diagnostic methods (UC; polymerase chain reaction, histopathology).
Methods: Pathogen-agnostic plasma microbial cell-free DNA sequencing was applied to banked samples from 116 outpatients included in 2 previous prospective studies of patients with antiretroviral treatment-naïve, advanced HIV (CD4 count ≤100 cells/µL). We then reviewed clinical and laboratory data for any people who tested positive for HHV-8 by mcfDNA sequencing or UC at baseline.
Results: HHV-8 was detected in 21 (18%) outpatients with advanced HIV by any method, with males comprising the majority (86%) and one-third originally from non-US countries (including Africa, Central America, and the Caribbean). Adding mcfDNA sequencing to UC proportionally increased HHV-8 detection by 38%, while also identifying in 18 (86%) people other microbes of potential interest, including common herpesviruses, Mycobacterium tuberculosis, and Pneumocystis jirovecii.
Conclusions: Plasma mcfDNA sequencing may improve UC in detection of HHV-8 infection, especially in immunocompromised outpatients, in whom early detection may facilitate appropriate management to prevent severe KS disease. The potential added benefit of the detection of other pathogens by mcfDNA sequencing may be particularly relevant for this population.
Smart tourism technologies and destination perception: implications for revisit intentions in mountainous destinations
Authors: Anjum Fatima , Ali Yousaf
Published: February 2025

Purpose - This study aims to investigate the impact of Smart Tourism Technologies (STT)
on tourists’ perceptions of a mountainous tourism destination, and how it influences their
intention to revisit. Additionally, this research examines the role of destination trust and
perceived risk in the relationship between perceived destination image and revisit intention.
Methodology - The data being utilized involved the accumulation of experience-based survey
data from 200 respondents and experts, leading to the application of the partial least square
structure equation modeling (PLS-SEM) approach.
Findings - The results showed that five out of six smart tourism technologies had a positive
effect on perceived destination image, leading to increased trust and decreased risk perceptions
towards the destination. The study found that trust strongly mediates the relationship between
perceived destination image and intention to revisit, while perceived risk does not have a
mediating effect.
Originality of the research - These findings offer significant insights for tourism authorities,
local governments, and tourism enterprises to enhance the competitiveness and long-term
sustainability of their destinations. This research is one of its kind that explored the relationship
based on six different attributes of smart tourism technologies that are specifically related to
Pakistan’s mountainous tourism destinations.
Library on Social Media
Authors: Pleshakova M. A.
Published: February 2025

The purpose of the article is an objective assessment of library’s representation on social media in a certain period. The article presents analytical cross-sectional study of the State Public Scientific Technological Library of the Siberian Branch of the Russian Academy of Sciences (SPSTL SB RAS) activities on social media and online media from July 28 to August 10, 2023. The analysis of mentions of the library on social media was carried out, the total number of which for the analyzed period amounted to 195 and received an average of 4.5 audience actions per message. The authors of the messages, mainly library specialists, were characterized, the main themes reflected in the published content were defined, trends were identified, audience engagement was analyzed and user reactions to the published content were assessed, as well as the advantages and disadvantages of current communication practices were determined. The author concludes that it is advisable to use analytical tools to build a successful communication strategy and increase the effectiveness of an organization’s activities on social media. A brief literature review on a particular topic was presented. It showed the wide research possibilities of data generated by social media and, at the same time, the insufficient development of the scientific research base of social media in the library and information sphere.
Philosophical Reflections of Robert Piercey on the Meaning of Reading
Authors: Ogleznev V. V.
Published: February 2025

The article summarizes the reflections on the meaning of reading by the contemporary Canadian philosopher Robert Piercey. The study showed on what grounds this particular philosophical practice was built. The heuristic of his arguments in favor of reading as an important sociocultural phenomenon is assessed, and Piercey’s vision of the future of reading in the era of digital technology dominance is presented.
Popular Science Literature in Saratov Province in 1918-1928: Subject Matter, Publishers, Authors
Authors: Kasovich A. S.
Published: February 2025

This article provides significant addition related to the history of book publishing in the Saratov province in 1918–1928. According to the study, the number of books and brochures published in Saratov province from 1918 to 1928 was at least 2294. Among them, there were popular science books. However, their role and significance in the regional book publishing of the first Soviet decade have not received adequate coverage to date. Therefore, it seems important not only to establish quantitative indicators of output, but also to identify the factors that determined the appearance of this type of books, their subject matter, dynamics, features, analyze the book repertoire, the composition of authors and publishers. The study identified 173 titles of popular science literature published in the region in 1918–1928 by three dozen publishing houses and publishing organizations. Among the above-mentioned publishing organizations were scientific institutes and organizations, as well as cooperative, state and even private enterprises. The authors included many well-known scientists and practitioners in the province, university professors. Reacting to the problems of the region, they tried to provide information on modernization of agriculture in the arid Volga region; countering epidemics and diseases that threatened the province in the 1920s; strengthening women’s health; civil defense, on the development of a new metric system of measures, etc. A number of authors and publishing organizations stimulated the interest of the local community in technical creativity and promoted general science, local history and other education-related spheres. The highest rise in the output of popular science literature, recorded in 1924–1926, was largely associated with the activities of the Moscow publishing house Novaya Derevnya. It was placed in the province for printing books and brochures created by both Saratov and metropolitan authors under the conditions of the NEP (New Economic Policy).
Kazakhstan National Project "Reading Nation"
Authors: Zamzayeva T. A.
Published: February 2025

The purpose of the article is to show the increase in the level of reading literacy among the population after the launch of Kazakhstan’s national project “Reading Nation”. In the conditions of rapid development of information and communication technologies there is a noticeable reduction in the share of regularly reading part of modern society, globalization of mass media, widespread availability of electronic audiovisual media, development of screen culture, social networks and entertainment industry has led to a reduction in reading of traditional books. Kazakhstan’s national project “Reading Nation” was developed on behalf of the head of state K.-J. Tokayev in 2020. The main goal of this project is to create in Kazakhstan an active environment for the creative development of children, modern youth and their parents, and to increase interest in reading among the population.
A Study of Vague Language in English News Reports
Authors: Ye Jiamei , Liang Yu
Published: February 2025

This paper elucidates and summarizes a selection of scholarly works dedicated to the exploration of vagueness within English news reports. Initially, it presents the foundational backdrop of this research domain, highlighting the imperative of conducting thorough investigations, the current state of research on this topic, and the principal findings derived from various theories within the international academic sphere. Furthermore, it meticulously examines the origins of the theoretical data and the underlying theoretical framework. The paper proceeds to enumerate, one by one, the essential terminology utilized in the discussion, elucidating their definitions and classification criteria. In the third chapter, a synthesis of research outcomes from a pragmatic perspective is offered, underlining the pivotal role and significance of fuzzy language in English news reporting. Additionally, it provides a balanced assessment and constructive suggestions. Lastly, the conclusion section concisely summarizes the entirety of the paper and proposes potential avenues for future research endeavors in this field.
OPTIMIZATION OF THE GENERAL ELECTION SUPERVISORY BODY IN ENSURING THE FULFILLMENT OF THE RIGHTS OF DISABILITIES
Authors: Pawestri Aprilina , Akbar Wahyu Nurdin , Rohmah Maimunatur
Published: February 2025

People with disabilities have physical, intellectual, mental and sensory limitations which may cause them to experience obstacles in carrying out their activities. One of them is related to fulfilling the right to vote in general elections. This has implications for the limited participation rate of voters with disabilities. The General Election Supervisory Agency (Bawaslu), as one of the election organizers, has the main task in the field of supervision. Can play a bigger role in efforts to increase participation of voters with disabilities. Contributed articles related to issues regarding the implementation of the voting rights of persons with disabilities and optimizing the role of Bawaslu in fulfilling the rights of persons with disabilities, focusing on Sampang and Bangkalan Regencies as research locations. The methodology used is empirical/sociological legal research. With data collection techniques through interviews with relevant respondents. The research results show (1) The implementation of the right to vote for persons with disabilities in general elections has not been fully realized, participation is still limited. (2) Optimizing the rights of persons with disabilities in general elections carried out by Bawaslu of Sampang and Bangkalan Regency, namely conducting outreach to disabled voters together with the Indonesian Association of Disabled People (PPDI) as well as carrying out participatory supervision, coordinating with the General Election Commission (KPU) at every stage of the election and establishing cooperation with local governments.
Prevalencia y factores de riesgo asociados a fluorosis dental en niños de 6 a 12 años de la Institución Educativa Primaria N° 36118 - Ambato, Huancavelica-Perú
Authors:   , Raymundo Rondinel Daniel Josue
Published: February 2025

OBJETIVO: El objetivo del estudio fue evaluar la prevalencia y los factores asociados a Fluorosis Dental en niños de 6 a 12 años en una institución educativa de Ambato, Huancavelica-Perú.
MATERIALES Y MÉTODO: El estudio fue observacional, transversal y prospectivo. La población estuvo conformada por 131 niños de 6 a 12 años en una institución educativa de Ambato, Huancavelica-Perú. Los niños de 6 a 12 años en una institución educativa de Ambato, Huancavelica-Perú cuyos padres hayan firmado el consentimiento informado se consideraron como criterios de inclusión. Los niños que tengan aparatología fija en los dientes a examinar, niños con lesiones o patologías que impidan la observación de los dientes seleccionados para el examen clínico se consideraron como criterios de exclusión. RESULTADOS: La prevalencia de fluorosis dental fue del 29.6% (32), entre los niños que presentaron fluorosis dental, la mayor cantidad de casos fueron niños de 10 años (31.3%) y 9 años (25%), hubo igual número de casos tanto en el sexo femenino 14 (50%) como masculino 14 (50%), todos los casos vivían en un área rural (100%). No se determinó una asociación significativa entre los factores de consumo de agua, leche, sal, bebidas envasadas, vegetales y carnes con fluorosis dental. Una asociación significativa entre el inicio de cepillado con crema dental de adulto y marca de la crema dental al iniciar cepillado con fluorosis dental fue encontrada.
CONCLUSIÓN: Se concluyó que la prevalencia de fluorosis dental fue del 29,6%, no hubo diferencias en la prevalencia según sexo. La ausencia de FD en esta población de niños de 6 a 12 años se produjo cuando no se usó pasta dental fluorada...
WITHDRAWN: Relationships Between Temperature and Precipitation Conditions and Tree- Ring Growth in Küre Mountains National Park in the Context of Climate Change
Authors: ATAY Selinay , İRDEM Cemil
Published: February 2025

The full text of this preprint has been withdrawn, as it was submitted in error. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.
Economic Growth and Income Inequality in Iraq: An Assessment of the Impact of Public Revenues and Transfers on Income Redistribution
Authors: Majeed Hawre Latif
Published: February 2025

Iraq's hydrocarbon wealth is a cornerstone of its Growth domestic product and government revenue, yet significant income inequality, as reflected by the Gini Index, poses persistent economic challenges. The unequal distribution of oil-derived income constrains public sector wages and investments, exacerbating social instability and impeding progress on the Human Development Index (HDI). Empirical analysis reveals a strong, consistent relationship between income inequality and developmental outcomes, with stationary trends indicating stable patterns over time. Addressing these disparities requires targeted interventions to promote sustainable growth. Reducing inequality and expanding opportunities for marginalized groups are essential. Leveraging information and communication technology to boost employment, alongside policies ensuring wage equity, labor inclusion, and social protection, can improve HDI outcomes. This study examines data spanning (1990 to 2024) to analyze Iraq's economic structure, employing robust empirical models that confirm these relationships. The analysis demonstrates high reliability, with no evidence of heteroskedasticity, serial correlation, or multicollinearity. Promoting equity across employment sectors and empowering collective bargaining are pivotal steps toward fostering a more inclusive and sustainable economic framework for Iraq.
Myeloid Cell Replacement Therapy Improves Function in Friedreich Ataxia Mice by Intercellular Mitochondrial Transfer
Authors: Gomez-Ospina Natalia , Cho Hyunmin , Sayana Ruhi , Koladiya Abhishek , Colella Pasqualina , Cho Sangkyun , Jahng James , Wu Joseph
Published: February 2025

Friedreich's ataxia (FA) is a mitochondrial disease caused by frataxin deficiency, leading to neurodegeneration and cardiomyopathy. Currently, there are no effective therapies for FA. Our study investigated the potential of myeloid cell replacement using bone marrow-derived cells in the YG8-800 mouse model. Combining Busulfan myeloablation, Colony-stimulating factor 1 receptor inhibition, and bone marrow transplantation, we achieved almost complete microglia and tissue macrophage replacement. This replacement facilitated mitochondrial transfer to various CNS cells, enhancing ATP synthesis and oxidative phosphorylation and improving the mice's growth and neurobehavioral performance. Similarly, replacing macrophages restored function and increased mitochondrial activity in the heart. In vitro studies showed that transferring intact mitochondria partially restored respiratory capacity in FA cells, which had a higher uptake, suggesting a specific compensatory mechanism for mitochondrial acquisition. These findings suggest that myeloid cell replacement can promote metabolic recovery in FA through mitochondrial transfer and provide a new approach to treating FA and other mitochondrial disorders.