bluuebunny/crossref_metadata_2025 huggingface dataset:
Islamic Banking: Past, Present and Future
Authors: Alshater Muneer Maher , Khan Ashraf , Hassan Mohammad Kabir , Paltrinieri Andrea
Published: December 2022

Purpose: The Islamic banking literature has been growing rapidly in the last decade. The aim of this study is to carry out a retrospective hybrid review to reveal this literature’s influential scientific actors (countries, institutions, journals, authors and documents), identify and discuss its most important streams, and finally, present a future research agenda. Methodology: We use a bibliometric approach, performing a review and objective analysis of 1,304 articles dealing with Islamic banking published during 1983–2021. We apply citation, keyword, and coauthorship analysis, as well as bibliographic coupling via VOSviewer software and Biblioshiny (an R package). Findings: We identify the influential aspects in the literature and discuss four important research streams: (1) overview, growth, and legal framework of Islamic banks; (2) Islamic banks’ performance and risk management practices; (3) customer and marketing perspectives of Islamic banking; and (4) the dynamics of efficiency in Islamic banks. Originality: This is one of the first studies to apply state-of-the-art methodology to review the literature related to Islamic banking and to highlight the dynamics of Islamic banks while presenting an extensive future research agenda.
Nanoparticles in biology and medicine
Authors: Stanovaya A. , Terekhova M. , Abashkin V. , Odabashi M. , Shcherbin D.
Published: December 2022

The authors give characteristics of nanoparticles used in medicine and biology, consider the mechanisms of drug transport with their help, as well as research conducted at the Institute of Biophysics and Cell Engineering of the National Academy of Sciences of Belarus in this area.
БЕЗПЕЧНІСТЬ ВИЗНАЧЕННЯ СТАНУ БУДІВЕЛЬНИХ МАТЕРІАЛІВ ЗА РАХУНОК ВИКОРИСТАННЯ БІОТЕСТУВАННЯ
Authors:   Таврійський державний агротехнологічний університет імені Дмитра Моторного, Чернишова Л.М. , Мовчан С.І. ,   Таврійський державний агротехнологічний університет імені Дмитра Моторного, Епоян С.М. ,   Харківський національний університет міського господарства імені О.М. Бекетова
Published: December 2022

The production of building materials is a significant reserve for increasing productivity and solving many environmental and economic problems in the construction industry. The use of any production waste in construction, especially liquid dehydrated galvanic waste, should ensure the environmental safety of their preparation and use, which are considered in the scope of the presented research. The work involves consideration of research results, which consist in the development of a block diagram of biological testing and the obtained tabular values, due to biological testing of certain types of building materials. Based on the obtained practical results, the optimal values for construction products have been developed, which determine the condition of construction materials through the use of biotesting. As a result of approbation of several test schemes, the practical values of input and heat-treated sludge (g / dm3), masonry mortar (%) and reinforced concrete with sludge additive (%) were obtained. Dunaliella-degree of immobilization for 5 days. (%); Elodéa canadénsis - the degree of inhibition of growth in length (% to control) at exposure (ext.) And Daphnia - survival at 48 days of exposure (%). The practical scheme and optimum values of production of building materials are offered, the initial application of use of products of biological testing (ceramic tiles with the addition of slime and other products with slime waste) is substantiated.
Ciências da natureza na base nacional comum curricular para os anos finais do ensino fundamental
Authors: Rego Elaine Cunha Morais Do , Oliveira Anatália Dejane Silva De
Published: December 2022

Avaliação da área de Ciências Naturais na nova BNCC para os anos finais do Ensino Fundamental
Comparativo: Pesquisa de Emprego e Desemprego x Pesquisa Nacional por Amostra em Domicílios (PED x PNAD)
Authors: Federal Companhia de Planejamento do Distrito
Published: December 2022

A presente Nota Técnica tem por objetivo a avaliação de alguns conceitos-chaves do mercado de trabalho e como eles são abordados pela PED e pela PNADC. A comparação desses conceitos permite uma visão crítica em relação aos resultados das duas pesquisas e à capacidade de extrapolação do resultado de uma pesquisa para o resultado observado na outra. Os conceitos-chaves selecionados foram: a População Economicamente Ativa (PEA), participação da PEA, desocupação e taxa de desocupação. Com o objetivo de buscar conceitos mais próximos entre as duas pesquisas, foram observados outros três conceitos: o percentual de ocupados em relação à população em idade ativa, o percentual de desocupados em relação à população em idade ativa e o percentual de inativos em relação à população economicamente ativa. Os conceitos foram selecionados pela sua importância e presença em ambas as pesquisas.
Comportamento dos Saldos Migratórios no Distrito Federal -1992-2007
Authors: Federal Companhia de Planejamento do Distrito
Published: December 2022

A migração ainda é um componente de expressão significativa na dinâmica demográfica do Distrito Federal, embora tenha apresentado saldos migratórios negativos nos últimos anos.
Neste trabalho, a análise baseia-se na comparação da dinâmica do fluxo migratório. Busca-se confrontar os resultados sobre imigração e emigração no Distrito Federal a partir dos dados da Pesquisa Nacional por Amostra de Domicílios - PNAD - 1992-2007.
As comparações dos dados das PNADs cobrem um período de 16 anos, intervalo esse que pode apontar tendências comportamentais que vêm sinalizando, de certa forma, como a migração contribui para o incremento populacional do Distrito Federal.
O imigrante é aqui definido como aquele que morava no DF na data da pesquisa e que, cinco anos atrás, residia em outra Unidade da Federação (migrante de data fixa).
DISTRITO FEDERAL SÍNTESE DE INFORMAÇÕES SOCIOECONÔMICAS 2010
Authors: Federal Companhia de Planejamento do Distrito
Published: December 2022

O “Distrito Federal - Síntese de Informações Socioeconômicas 2010” pretende atualizar os estudos elaborados pela CODEPLAN em 2006, 2007 e 2008, disponíveis no site www.codeplan.df.gov.br, com a finalidade de proporcionar aos estudantes, professores, pesquisadores e à população em geral, melhor compreensão do Distrito Federal.
O último estudo contém informações, de acordo com a realidade atual, sobre o território, a população e suas interações socioeconômicas. É apresentado em cinco capítulos: Caracterização do Território; Caracterização Político - Administrativa; Caracterização da População; Caracterização da Economia e Caracterização da RIDE - Região Integrada de Desenvolvimento do Distrito Federal e Entorno.
Na Caracterização do Território destacam-se, entre outras, informações sobre o clima, relevo, recursos hídricos, flora e fauna, histórico da capital, estrutura urbana de Brasília e características das 30 Regiões Administrativas. No que se refere à população, a Pesquisa Nacional por Amostra de Domicílios - PNAD/IBGE/2008 realizada pelo Instituto Brasileiro de Geografia e Estatística - IBGE estimou para o Distrito Federal um total de 2.526.000 habitantes. Destes, 1.290.000 são migrantes, oriundos em sua maioria das regiões Nordeste e Sudeste.
O Distrito Federal, face às peculiaridades de sediar a capital do país, e desempenhar funções preponderantemente institucionais e administrativas, concentra 93,16% do Produto Interno Bruto no segmento de serviços. O PIB per capita do DF, indicador de crescimento econômico é o maior do país.
O desenvolvimento econômico do DF nas quatro primeiras décadas de sua existência é marcado pela expansão da construção civil. Apenas nos anos 1980 que o setor de serviços passou a ser fortemente incorporado à economia.
O estudo contempla dados sobre educação, saúde, rede hospitalar, segurança, energia elétrica, saneamento básico, infraestrutura rodoviária, ferroviária e turismo.
As informações apresentadas foram levantadas por meio de pesquisas secundárias, em publicações disponíveis na CODEPLAN e em levantamentos junto aos órgãos públicos e entidades privadas do Distrito Federal.
Demografia em Foco 1 - Indicadores de Desigualdade Social no Distrito Federal
Authors: Federal Companhia de Planejamento do Distrito
Published: December 2022

A arte/ciência de administrar o conjunto das políticas públicas em cada uma das Unidades Federadas Brasileiras tem o seu sucesso determinado pelo equilíbrio conferido entre o plano, os recursos necessários para a execução deste plano e a conjuntura em que se dará esta execução. Alimentando estes três aspectos da gestão pública encontram-se os dados e as informações, cuja obtenção, tratamento e disseminação são parte da missão da Companhia de Planejamento do Distrito Federal - CODEPLAN.
É neste contexto que entendemos o que fundamenta a elaboração do trabalho apresentado: colaborar para o aperfeiçoamento das ações dos gestores locais, conferindo maior clareza para o entendimento da realidade e das variáveis que devem ser consideradas para permitir este aperfeiçoamento.
Resultado do trabalho do Núcleo de Estudos Populacionais da CODEPLAN, em parceria com o Fundo de População das Nações Unidas – UNFPA, este volume da série “Demografia em Foco”, apresenta achados ainda não explorados da Pesquisa Distrital por Amostra de Domicílios - PDAD, realizada em 2004, para a melhor compreensão da estrutura da população do Distrito Federal, segmentada em regiões de acordo com suas tipologias norteadoras (renda, condições domiciliares e outras).
DISTRITO FEDERAL SÍNTESE DE INFORMAÇÕES SOCIOECONÔMICAS
Authors: Federal Companhia de Planejamento do Distrito
Published: December 2022

O “Distrito Federal Síntese de Informações Socioeconômicas” foi idealizado para proporcionar aos estudantes e a comunidade uma melhor compreensão do Distrito Federal, fornecendo informações de acordo com a realidade atual.
O trabalho se divide em seis capítulos, a saber: Introdução, Caracterização do Território, Preservação da Ocupação Territorial, Caracterização da População, Caracterização da Economia e Entorno do Distrito Federal.
As informações apresentadas foram levantadas por meio de pesquisas secundárias em publicações disponíveis na Codeplan e em levantamentos junto aos órgãos públicos e entidades privadas do Distrito Federal.
O enfoque dado ao estudo é o de apresentar uma breve descrição e a última informação disponível sobre o tema, possibilitando ao usuário o conhecimento da realidade de Brasília e das demais Regiões Administrativas do DF.
Emergências Pediátricas - Edição I
Authors: Lopes Amanda Brandão , Vilefort Laís Assunção
Published: December 2022

O livro Emergência Pediátricas foi pensado e construído pensando no cuidado da criança doente ou ferida e no ganho de conhecimento do profissional envolvido com esse atendimento. Ele apresenta informações essenciais dedicadas especificamente às emergências pediátricas e adolescentes. É a primeira publicação da Editora Pasteur com foco específico para este nicho da medicina pediátrica e esperamos nas proporcionar ao leitor experiência no manejo de cuidados agudos mais imediatos, como gerenciamento de vias aéreas pediátricas, trauma agudo, ingestão de objetos pontiagudos e toxicologia. Essa é a primeira edição de uma série sobre cuidados em emergência. O livro é dedicado às equipes multiprofissionais que rotineiramente enfrentam o desafio de pensar e agir com rapidez e eficiência. A todos os autores, a Editora Pasteur agradece a contribuição de excelência.
Psychological well-being amongst students in a Malaysian medical college one year into the COVID-19 pandemic: a cross-sectional study
Authors: Kong Sylvia W. , Cheong Sabrina Pei Y. , Yong Jade L. , Ong Edmund Liang C.
Published: December 2022

Background

The frequent disruption to the delivery of education and the switch to online learning amidst the COVID-19 pandemic affected students’ mental health. The objectives of the study were to explore the levels of anxiety, depression, somatic symptoms, and stress among students during the COVID-19 pandemic and their associations with sociodemographic status, clinical teaching, and concerns about COVID-19.

Methods

A cross-sectional study was conducted using convenience sampling via an online self-administered questionnaire-based survey with 285 participants. The survey included questionnaires on sociodemographics, anxiety, depression, somatic symptoms, and stress levels using a validated questionnaire. Data was analyzed using Spearman’s correlation test and ordinal logistic regression to identify correlations between psychological well-being and the effectiveness of e-learning.

Results

More than half of the students reported anxiety (57.2%), depression (58.6%), somatic symptoms (54.4%) and moderate to high stress (79.7%) during the pandemic. Students who stated that online role players were not helpful had increased anxiety levels (rho=-0.18, P=0.005). However, somatic symptoms were reduced among students who found campus role players helpful (rho=0.16, P=0.012). More than half the participants (55.8%) felt that they were supported by the university during the COVID-19 pandemic, although most students (91.6%) sought clear information and prompt updates from the university. We found that students with psychological distress experiencing anxiety (OR=2.47, 95% confidence interval, CI=1.49-4.08), depression (OR=3.22, 95% CI=1.94-5.34), somatic symptoms (OR=2.94, 95% CI=1.76-4.91, P<0.001), and stress (OR=3.08, 95% CI=1.76-5.41) would value more mental health support from the university.

Conclusions

The university should consider increasing campus role-play sessions and providing prompt updates and mental health resources to help students cope better psychologically during the pandemic.
Development of score models for severe course risk assessment of febrile form of tick-borne encephalitis
Authors: Filatova E. N. , Ilyinskikh E. N. , Reshetova A. V. , Puchkova N. N. , Portnyagina E. V. , Petrova E. I. , Minakova Iu. V. , Voronkova O. V. , Motlokhova E. A. , Naydenova N. E. , Ilyinskikh N. N.
Published: December 2022

Background. There is no current generally accepted classification and clinical approaches to assess the clinical course severity of tick-borne encephalitis.   The aim is to develop models for the quantitative severity scores of the febrile form of tick-borne encephalitis using the most informative predictors.   Materials and methods. In accordance with clinical criteria of the height and duration of fever, two groups of 9 and 30 patients (52.2 ± 4.3 and 49.5 ± 3.9 years old) with severe and non-severe febrile form of tick-borne encephalitis were formed. The study design was a retrospective case-control study. Statistical significance assessment of variables was carried out using the chi-square test. The odds ratios were also calculated. The development of logistic regression models was carried out using Statistica 12.0 modules.   Results. A questionnaire of febrile form of tick-borne encephalitis severity score was developed using the height of fever and 11 most informative clinical predictors including arthralgia, chills, sleep disturbance, dizziness, orbital pain, nausea, photophobia, myalgia, severe headache, vomiting and meningism. To predict the severe clinical course of febrile form of tick-borne encephalitis, two logistic regression models were developed with or without severity score assessment of fever syndrome (coefficients α and β were –12.13 and 0.94 and –5.78 and 0.75 for models 1 and 2, respectively). Models 1 and 2 demonstrated a high predicted probability for cut-off values equal to 14 and 9 points and excellent quality of prediction test (AUC are equal to 0.99 and 0.98, respectively).   Conclusions. The models of severity score demonstrated high predicted probabilities to predict severe clinical course of febrile form of tick-borne encephalitis, which can be used in clinical practice and for scientific purposes.
Comparative characteristics of clinical, laboratory and instrumental indicators in children with seasonal influenza depending on the virus strain
Authors: Kazantseva E. D. , Petrova A. G. , Vanyarkina A. S. , Novikova E. A. , Moskaleva E. V. , Rychkova L. V.
Published: December 2022

Introduction. According to the literature, it is known that clinical signs and symptoms of influenza may differ depending on age, the state of the human immune system, the serotype of the virus and its virulence. Intoxication, catarrhal and hyperthermia are main symptoms of influenza, but the disease does not always proceed classically, it may hide under the mask of other infections.   The aim was to conduct a comparative analysis of clinical, laboratory and instrumental parameters in children with influenza A(H1N1) and A(H3N2).   Materials and methods. A single-stage retrospective comparative study was carried out with the participation of 96 children from 1 month of age up to 13 years old with a diagnosis of influenza, who were hospitalized at the Irkutsk Regional Infectious Clinical Hospital from December 2018 to January 2019. Clinical and laboratory features of the course of influenza in children were determined depending on a viral strain.   Results. The structure of morbidity: influenza A(H1N1) – 70 people (73 %), influenza A(H3N2) – 20 children (21 %), influenza A clinically unvaccinated – in 3 people (3 %), mixed viral infection influenza H1N1 + adenovirus infection – 2 cases (2 %), mixed viral infection H1N1 flu + RS-virus – 1 case (1 %). In the clinic of both strains of the virus, symptoms prevailed: runny nose, dry cough, fever, intoxication. Muscle pain and pharyngeal hyperemia were significantly more common in influenza A(H1N1), the duration of symptoms did not differ. Lymphocytosis was more often observed in influenza A(H1N1), monocytosis – in influenza A(H3N2) (р < 0.05). In 64 % of cases, patients with influenza A(H1N1) had a high leukocyte index of intoxication (odds ratio – 2.2).   Conclusion. The symptoms of different influenza A viral strains virus in children are the same, however, muscle pain and hyperemia of the pharynx prevails in children with influenza A(H1N1).
Editor-in-chief’s preface to Issue 5-2, 2022
Authors: Kolesnikov S. I.
Published: December 2022

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Single-stage combined urethroplasty for extended strictures of the anterior urethra of tuberculous origin
Authors: Volkov A. A. , Budnik N. V. , Zuban O. N. , Reshetnikov M. N. , Plotkin D. V. , Bogorodskaya E. M. , Yarovaya E. V.
Published: December 2022

Background. Urethral strictures are currently one of the most complex pathologies in reconstructive urology. The most promising direction in this area is the development of single-stage surgical interventions that meets modern requirements for the quality of life of patients.The aim of the study. To evaluate the possibility and the effectiveness of surgical treatment of extended recurrent tuberculous urethral strictures in men using a combination of a skin flap and a buccal graft. In the literature, there is no description of the use of this technique in patients with urethral tuberculosis.Materials and methods. We observed 44 patients with urethral tuberculosis. Three men from this group of patients were diagnosed with tuberculous (post-tuberculous) extended recurrent stricture of the anterior urethra and they underwent combined single-stage urethroplasty with a ventral fasciocutaneous flap and a buccal graft using the inlay method in the penile region and with a buccal graft using the ventral onlay method in the bulbous urethra. Ultrasound of the urethra served as a method that determines the possibility of performing this surgery in case of maintaining a sufficient width of the urethral plate with a moderate degree of spongiofibrosis.Results. Patients were under observation for 34, 50 and 54 months and have good long-term functional results – all patients have unassisted urination and no residual urine. Post-micturition dribbling persists in 1 patient. The overall effectiveness of the treatment of these strictures, taking into account the treatment of repeated cases of the disease recurrence, is high.Conclusion. This technique demonstrates the possibility of performing a single-stage reconstruction of the anterior urethra in patients with extended recurrent tuberculous (post-tuberculous) urethral strictures and is also applicable for the surgical treatment of urethral strictures of other origins.
Modulating effect of Cu(II) complexes with enamine and tetrazole derivatives on CYP2C and CYP3A and their cytotoxic and antiproliferative properties in HepG2 spheroids
Authors: Klyushova L. S. , Golubeva Yu. A. , Vavilin V. A. , Grishanova A. Yu.
Published: December 2022

CYP2C and CYP3A cytochromes are induced by a variety of compounds and affect the pharmacokinetics and pharmacodynamics of a large number of drugs. Currently, the possibility of using copper coordination compounds in antitumor therapy is being actively studied. Evaluation of potential interactions between new molecules and P450 cytochromes is necessary at an early stage of drug design.The aim. To study the modulating effect of Cu(II) complexes with enamine and tetrazole derivatives on CYP2C9, CYP2C19 and CYP3A4 and their cytotoxic and antiproliferative properties on normal human lung fibroblasts MRC-5 and a 3D model of hepatocellular carcinoma HepG2.Materials and methods. Cytotoxic and antiproliferative activities of copper(II) complexes – [CuL2] (1), [Cu2(bipy)2(PT)4] (2), [Cu2(phen)2(PT)4] (3), {[Cu(phen)(MT)2]∙H2O}n (4) (L – anion of 2-anilinomethylidene-5,5-dimethylcyclohexane-1,3-dione; PT – 5-phenyltetrazolate anion; MT – 5-methyltetrazolate anion; bipy – 2,2’-bipyridine; phen – 1,10-phenanthroline) – were examined in 2D and 3D models using fluorescence-based phenotypic screening. The modulating effect on CYP2C9, CYP2C19 and CYP3A4 was studied using fluorescence-based targeted screening. The results of CYP3A4 expression were confirmed by real-time reverse transcription polymerase chain reaction (RT-PCR).Results. Complex (1) increases the CYP3A4 expression and does not affect CYP2C9 and CYP2C19 expression. Complex (2) has no modulating effect on CYP2C and CYP3A. Complexes with 1,10-phenatrolin (3) and (4) induce CYP3A4, inhibit CYP2C9 and do not affect CYP2C19 expression. All compounds have a dose-dependent cytotoxic effect on HepG2 and MRC-5: the compound with 5-methyltetrazolate anion (4) has the same effect on cell lines, compounds with 5-phenyltetrazolate anion (2) and (3) have selective effect. Complexes with 1,10-phenatrolin are effective on both 2D and 3D models.Conclusion. The [Cu2(phen)2(FT)4] complex (3) can be used as a basis for creating an antitumor compound, but further modification of the structure is required to increase the selectivity to tumor cells.
Verification of a case of mixed infection with Lyme disease, tick-borne encephalitis and COVID-19
Authors: Leonova G. N. , Shutikova A. L. , Popov A. F. , Shchelkanov M. Yu.
Published: December 2022

Background. The relationship between pathogens of new diseases and tick-borne infections is an underinvestigated direction in the problem of infectious diseases.The aim. To show the features of identifying the markers of Borrelia burgdorferi, tickborne encephalitis and SARS-CoV-2 pathogens on the example of a case of a triple mixed infection (Lyme disease, tick-borne encephalitis and COVID-19) and using comprehensive studies.Methods. In 2019–2021, a comprehensive study of 7 blood samples from a patient with mixed infection was carried out. We used real-time polymerase chain reaction (PCR), enzyme immunoassay (ELISA) and determined antigen, IgM, IgG antibodies, and avidity index (AI) of IgG antibodies.Results. Ixodid tick-borne borreliosis was diagnosed in a patient 5 months after contagion. Only high-avid Lyme-IgG antibodies were detected. Low-avid Lyme- IgG antibodies appeared against the background of a reduced general condition. At the same time, high-avid IgG (cut-off index (COI) – 7.8) and IgM (COI = 1.2) antibodies to the TBE virus were detected. In July 2020, the patient was infected with SARSCoV-2. TBE virus which passed into the body simultaneously with Borrelia in the fall of 2019 was activated. Although the patient did not have specific symptoms of TBE, in subsequent blood samples (No. 4, 5, 6) we found TBEV antigen (optical density (OD) – 4.3; 1.9 and 2.0 respectively) and IgM (COI = 1.3; 0,9 and 0 respectively). These results were recognized as TBEV activation, which contributed to an increase in the avidity of IgG antibodies (AI = 65 %; 100 % and 63 % respectively). IgM antibodies to SARSCoV-2 virus were not detected, as opposed to the high levels of IgG (COI = 8.2; 8.1; 8.4 and 14.7 respectively).Conclusions. Therefore, using not only the common methods of diagnosing (PCR and ELISA), but also the determination of the antibody avidity degree, we have shown that when analyzing a case of a triple mixed infection, B. burgdorferi dominates in the human body and causes a long-term chronic course of the disease.
Comorbid disease in children and adolescents with perinatal HIV infection: A pilot study
Authors: Manaenkova T. L. , Bairova T. A. , Sambyalova A. Yu. , Paramonov A. I. , Belyaeva E. V. , Bugun O. V. , Rychkova L. V.
Published: December 2022

Background. With the increased use of combination antiretroviral therapy, the mortality of people living with HIV has decreased significantly, which has led to an increase of comorbidity and secondary HIV-related pathology in both adults and also in children and adolescents living with HIV infection. The incidence of children and adolescents with HIV infection and those in the general population varies significantly.The aim. To assess the frequency and range of chronic comorbidities in children and adolescents with perinatal HIV infection Methods. We carried out an observational study. Data on the incidence of 161 children with perinatal HIV infection registered in the Irkutsk Regional AIDS Center were copied.Results. Overall incidence of tuberculosis (18633.5 per 100 000 children), diseases of the digestive system (24844.7 per 100 000 children), diseases of the eye and adnexa (28571.4 per 100 000 children), diseases of the nervous system (18012.4 per 100 000 children), mental and behavioral disorders (13,664.6 per 100 000 children) in children with perinatal HIV infection is the higher than in children of comparable age. The overall incidence values of the endocrine system diseases, eating and metabolic disorders, diseases of the ear and mastoid process, diseases of the circulatory system, diseases of the genitourinary system, as well as congenital disorders and chromosomal disorders in children and adolescents with and without perinatal HIV infection are comparable.Conclusion. The prevalence of diseases of the circulatory, respiratory and genitourinary systems in children with perinatal HIV infection is comparable to that in the corresponding population. Prevalence of tuberculosis, anemia, diseases of the gastrointestinal tract, diseases of the eye and adnexa, diseases of the nervous system, mental and behavioral disorders is higher compared to children not exposed to HIV.
Efficacy of olocizumab in treatment of COVID-19 patients
Authors: Goma T. V. , Kalyagin A. N. , Ryzhkova O. V. , Soloveva N. S.
Published: December 2022

Background. Production of pro-inflammatory cytokines including interleukin 6 (IL-6) is activated in COVID-19. Using olokizumab which inhibits IL-6 production in treatment of COVID-19 is pathogenetically justified.The aim. To study in real clinical practice the efficacy and safety of using the IL-6inhibitor (olokizumab) in treatment of patients with confirmed COVID-19 pneumonia.Materials and methods. The first group included 41 hospitalized patients with confirmed COVID-19 pneumonia having complex therapy including olokizumab. The control group consisted of 66 patients with confirmed COVID-19 pneumonia who did not have therapy with IL-6 inhibitor. We analyzed clinical (volume of lung involvement, respiratory failure degree, body mass index) and laboratory data (levels of T-troponin, lactate, procalcitonin, natriuretic peptide, C-reactive protein, fibrinogen, D-dimer, ferritin, erythrocyte sedimentation rate, glomerular filtration rate).Results. The groups did not differ in gender, age, body mass index of patients, volume of lung tissue injury, and duration of hospitalization (p > 0.05). Respiratory failure of 2–3rd degree was more common in patients of the first group (χ2 = 6.3; p = 0.010). The initial levels of C-reactive protein (50.9 [34.2; 76.2] and 32.2 [9.9; 69.1] mg/L respectively; p = 0.009) and fibrinogen (6.0 [5.3; 6.7] and 5.2 [4.3; 6.2] g/l respectively; p = 0.005) in patients having therapy including olokizumab were significantly higher than in the control group. The levels of erythrocyte sedimentation rate, fibrinogen and ferritin, D-dimer, detected upon admission of patients to the hospital, didn’t have statistically significant differences. At discharge, the erythrocyte sedimentation rate in patients receiving olokizumab was statistically significantly lower (9.0 [5.5; 14.5] and 13.0 [7.0; 27.0] mm/h; p = 0.018).Conclusions. Using olokizumab in the treatment patient with COVID-19 pneumonia has demonstrated a positive effect on clinical and laboratory parameters (erythrocyte sedimentation rate, fibrinogen level) in patients with pronounced inflammatory changes and respiratory impairment.
Assessment of air quality at Takoradi technical university (TTU) satellite campus (akatakyi) and it’s environ
Authors: Esther B. Kyere  , Albert K. Arkoh  , Joseph Ellis  , Patrick Bluvi
Published: December 2022

Air pollution poses a challenge to human life, meanwhile, air quality in human inhabitancy is usually given less attention. Therefore, the study aims at assessing air pollution at Takoradi Technical University (TTU-Akatakyi campus) and its environs. The assessment was done to determine the particulate matter in the study area using a Haz-dust Monitor-5000. Before data collection, the sampler was calibrated and set to start for 24 hours. Data recorded were analysed using Microsoft Office Excel. The results were compared to EPA-Ghana and WHO Guidelines Values. TTU Akatakyi Campus, Bokro Township, and Diamond Cement Factory recorded mean PM1 values of 3.10, 3.19, and 3.56 mg/m3, respectively. The highest PM2.5 mean value (3.57 mg/m3) was recorded at Diamond Cement Factory whereas the least PM2.5 (3.11mg/m3) was at TTU-Akatakyi Campus. The highest PM10 mean value (3.80 mg/m3) was recorded at Diamond Cement Factory while the least (3.12 mg/m3) was at TTU Akatakyi Campus. The highest recorded Total Suspended Particulate (TSP) mean value (3.62 mg/m3) was at Diamond Cement Factory while the least (3.11 mg/m3) was at TTU Akatakyi Campus. The recorded values were above EPA-Ghana and WHO guidelines, which implies that the air quality in the study area at the time of the study was harmful to human health.
Study on morphological characterization of Citrus macroptera Mont collected from garo hills district Meghalaya, India
Authors: Pronomi M Sangma  , Suresh Chellakan Perinba
Published: December 2022

The work was undertaken to study the variability in Citrus macroptera from five Garo hills district. Many important horticultural plant species, viz. Citrus are known to have originated from this region. Citrus macroptera Mont. is one of the endangered, semi-wild species which have found to exist in various parts of NE region, including Meghalaya. Thirty accession of Citrus macroptera from five different districts of Garo Hills, Meghalaya were collected to study its variability in quantity and quality parameters. In the study significant to highly significant differences were observed among the genotypes. The analysis of variance for different parameters such as tree height, tree girth, leaf length, leaf width, fruit width, fruit length, fruit weight, number of fruit segment, rind thickness, number of seeds per segment, seed length, and seed width varied significantly among accession. Variability among accession collected from different location shows the great scope for genetically potential genotypes for cultivation and also for their exploitation in plant breeding programme.
Differential antimicrobial extract activity of Graviola (Annona muricata) on gram positive and gram- negative antibiotic-resistant bacteria
Authors: Meaghan Bruskoski  , Brent Ito  , Balbina J Plotkin  , Monika Konaklieva  , Ira M Sigar
Published: December 2022

New agents are needed with the increasing prevalence of multidrug-resistant (MDR) bacteria. Identification of plants with activity against MDR bacteria is of increasing importance. The antimicrobial activity of commercially available Graviola preparations against 38 clinical and laboratory isolates, representing MDR and drug-sensitive Gram positive and Gram negative bacteria, was measured by broth microdilution. Commercially Graviola fruit, as well as leaves/stems preparations, exhibited both inhibitory and cidal activity. However, the fruit preparation showed significantly less activity than the leaves/stems preparation. The Graviola leaves/stems preparation activity titer ranged from 1:4 to 1:16 against MDR Gram positive and Gram negative bacteria; including methicillin-resistant Staphylococcus aureus (MRSA), extended-spectrum β-lactamase (ESBL) Escherichia coli, Acinetobacter baumannii, and Klebsiella pneumoniae carbapenemase (KPC). However, the preparation had no effect on Lactobacillus. In addition, further extractions of the leaves/stems were tested against MRSA and MSSA in an in-vitro biofilm wound infection model. The polar extracts of the stems/leaves exhibited the highest bactericidal activity in preventing and inhibiting biofilm formation. Thus, Graviola leaves/stems extracts showed differential activity for phytochemical utility against multidrug-resistant bacteria.
Strengthening the Role of Village-Owned Enterprises for Agriculture and Livestock SMEs
Authors: Nugeraha Prasetya , Agung Pratama Maulana , Adistya Diang , Efendi Ahmad , Septiani Winda , Handika Firman , Febryani Siska , Lola Widisono Rachmawati , Sari Murni , Ami Nugroho Cristofer , Ali Suprihatin
Published: December 2022

Village-Owned Enterprises, or BUMDes, are local business institutions that use village resources to enhance the village economy. However, in numerous locations where BUMDes already exist, some of these BUMDes are not working smoothly and are inactive. As a result, the construction of a BUMDes business unit must be tailored to the capabilities of the community. The purpose of this research is to explore more into the role of BUMDes for SMEs in agriculture and livestock. This study employed a qualitative research method with a descriptive approach. This study's data is derived from primary sources. While data gathering is accomplished by the use of observation, interviews, and documentation. According to the study's findings, BUMDes Purworejo and BUMDes Lugusari have been able to support the community's economy in their villages, where the majority of residents work in the agricultural and livestock industries. BUMDes Purworejo and BUMDes Lugusari contribute to the village economy through business units such as PAMDes, Quail Farms, Village Markets, and Pond Management Businesses.
Asiakasturvallisuuden oikeudellisia ulottuvuuksia sosiaalihuollossa
Authors: Lohiniva-Kerkelä Mirva
Published: December 2022

Artikkelissa tarkastellaan asiakasturvallisuutta sosiaalihuollossa oikeudellisesta näkökulmasta palvelujen järjestämisvastuun, palveluntuottajien ja ammattihenkilöiden velvollisuuksien ja vastuiden sekä toiminnan valvonnan kannalta. Aineistona on käytetty lainsäädäntöä, esitöitä sekä valvontaviranomaisten tuottamaa materiaalia. Asiakasturvallisuuden takaaminen on sosiaalihuollon lainsäädännön keskeinen tavoite, jota toteutetaan asettamalla vaatimuksia esimerkiksi tiloille, henkilöstölle ja toimintatavoille. Sisällöllisesti asiakasturvallisuus on yhteydessä asiakkaan oikeuksiin ja sosiaalihuollon laatuun. Sääntelyssä ja ohjauksessa korostuu yleensä välittömässä asiakastilanteessa tapahtuva toiminta, kun taas päätöksentekoon asiakasasiassa sisältyviä asiakasturvallisuusriskejä on nostettu esiin vähemmän. Ongelmana on erityisesti se, että potilas- ja asiakasturvallisuuden suunnitteluun, toimeenpanoon ja seurantaan liittyvät velvoitteet ovat yleisiä sekä hajallaan useassa eri laissa ja niitä tarkentavissa määräyksissä ja ohjeistuksissa, jolloin niiden soveltaminen käytännössä voi olla vaikeaa.
Agamennone (ri)figurato
Authors: Tusini Gian Luca
Published: December 2022

Painting of the early Contemporary Age reserves some attention to the
mythical figure of Agamemnon and the characters closely involved in his story, mostly
including him in figurative works that retrace the salient moments of the Homeric and
especially tragic narrative, the latter with various modulations. The twentieth century,
on the other hand, tends perhaps to isolate his figure, to make him a kind of monument
to himself, with singular experiences in stage design. The result is a continuous redefinition
that gradually dilutes the very recognizable identity of the characters in the drama,
now pondered within more ‘intimate’ and personal poetics, now transfigured into open
and polysemic symbolic forms.
Rivisitazioni del vanto epico del guerriero nell’Orestea
Authors: Medda Enrico
Published: December 2022

A peculiar feature of Aeschylus’s Oresteia, a trilogy characterized by a
pervasive blending and overlapping of different linguistic registers, is represented by
the reprise and refunctionalisation of the boast of epic warriors on the lying body of
a defeated enemy. This paper analyses how the topoi of Homeric boast are applied by
Aeschylus to characters who, in different ways, either come into conflict with the epic
model (Clytemnestra, Aegisthus, Orestes) or are not up for it because of a disastrous
unawareness of the real situation (Agamemnon). This allows the poet to cast light on
essential nuances of his new dramatic construction.
ANALISIS KINERJA PARKIR SEPANJANG JALAN WALIKOTA MUSTAJAB SURABAYA
Authors: Yulmida Damarta Anugrah , Mudjanarko Sri Wiwoho , Setiawan M Iksan , Limantara Arthur Daniel
Published: December 2022

Jumlah kendaraan yang meningkat di kota Surabaya membutuhkan lahan parkir yang mencukupi. Sepanjang ruas jalan protokol banyak dijumpai kendaraan parkir di tepi jalan. Larangan parkir masih dijumpai kendaraan parkir. Hal ini menunjukkan kebutuhan parkir sangat tinggi. Jalan Walikota Mustajab Surabaya menjadi salah satu objek penelitian parkir. Kemacetan yang terjadi di sepanjang jalan tersebut sangat menganggu aktifitas lalu lintas. Oleh karena itu, perlu dilakukan analisis kinerja parkir di ruas Jalan Walikota Mustajab Surabaya.Tujuan dari studi ini adalah untuk mendapatkan solusi yang dapat ditawarkan untuk menanggulangi kejenuhan di ruas Jalan Walikota Mustajab Surabaya. Metode yang mengunakan Manual Kapasitas Jalan Indonesia (MKJI) dan PedomanTeknik Direktorat Jendral Perhubungan Darat. Data yang dibutuhkan berupa data primer dan data sekunder. Data primer berupa pengamatan  data lapangan yang terdiri  dari data jumlah kendaraan parkir, durasi parkir dan volume lalu lintas, sedangkan data sekunder didapatkan dari peta ruas Jalan Walikota Mustajab Surabaya. Hasil analisis studi diperoleh ruas jalan Walikota Mustajab telah mengalami kejenuhan dengan nilai derajat kejenuhan sebesar 1,31. Alternatif penanganan adalah membuat Off Street Parking, yang nilai derajat kejenuhannya berkurang sampai 0,85. Setelah diberlakukan Off Street Parking  derajat kejenuhan  menjadi berkurang. Selain itu dari segi karakteristik parkir pada ruas – ruas Jalan Walikota Mustajab diperoleh hasil volume parkir sebesar 544 mobil, dimana kapasitas parkir mencapai 58 Satuan Ruang Parkir. Akumulasi parkir terbesar  didapatkan nilai sebesar 29 mobil dan durasi parkir terlama adalah 60 menit dengan nilai 22.30% pada ruas Jalan Walikota Mustajab. Pada jalan Walikota Mustajab ini sistem tarif parkir masih menggunakan sistem tarif tetap dengan harga Rp.1500,- untuk sepeda motor dan Rp.3000,- untuk mobil. Disarankan memperbanyak penyediaan fasilitas  Off Street Parking seperti lahan kosong parkir Bangi Kopi Tiam yang memiliki pa­­­­njang 32 meter dan lebar 22 meter. Kata kunci : Kinerja parkir, MKJI, kapasitas jalan
Analytical Hierarchy Process (AHP) for Maintenance Management at Bali Mandara Hospital
Authors: Mosa Maria Imaculata Goran , Sinarta I Nengah , Eryani I Gusti Agung Putu
Published: December 2022

The absence of an assessment of the level of damage and the condition of the Bali Mandara Hospital building makes the maintenance management plan contained in the umbrella contract only based on the damage that occurred in the previous year. Therefore, it is very difficult to determine which building infrastructure components require maintenance and repair first. This study examines the priority scale of infrastructure maintenance at Bali Mandara Hospital using the Analytical Hierarchy Process (AHP). In this study, researchers used a quantitative-descriptive approach. The assessment of the building condition index value is then determined by the priority scale of each component using the Analytical Hierarchy Process (AHP) method with the help of the Expert Choice Version 11 application and the SWOT Method. The results showed that the index value for the infrastructure condition of the Bali Mandara Hospital building was 89.492 with very good condition criteria and was in zone I, while the highest priority scale was faucets, namely 1,000, and the lowest priority was action on a scale of 0.050, where this priority scale can be used in planning. Standard Operating Procedure (SOP) and efficient maintenance management. So based on the results of this study, with SWOT analysis, maintenance management can develop a more effective and efficient maintenance plan and Standard Operating Procedure (SOP) by the building condition index and existing priority scale.
The Ultrasonic Pulse Velocity and Lagrangian Approaches to Predict the Effective Thickness and Homogeneity of the Sandwich Panel
Authors: Ma'arif Faqih , Widodo Slamet , Nugroho Maris Setyo , Tafrikan Mohamad , Gao Zhengguo
Published: December 2022

Non-destructive testing can be applied to various things, including sandwich panels. Sandwich panels made of EPS are greatly affected by the mixing process. Bad mixing can affect the level of homogeneity and reduce quality. In addition, the improper thickness of layers and cores can result in wall damage. For this reason, carrying out a non-destructive test on the sandwich panel is necessary. This study aims to determine the homogeneity of the material and predict the dimensions of the EPS core and layer. Experimental testing was conducted using Ultrasonic Pulse Velocity (direct method) with 90 points. The test object consisted of six sandwich panel walls with three variants, each with dimensions and layer thickness of 15 mm, 20 mm, and 25 mm, respectively, while the core layer size was 70 mm, 80 mm, and 90 mm, respectively. The test results were analyzed on travel time and wave velocity using a statistical analysis approach including covariance, Kolmogorov-Smirnov, ANOVA, t-test, and Lagrangian. The analysis results show that the mixture's homogeneity can be determined based on the ultrasonic pulse velocity. The proposed Lagrange analysis can reveal the behavior of the propagation speed. Based on the results of the Lagrange approach, the highest speed is obtained at a thickness of 80 with a maximum speed of 2.395 km/s. The results of this study contribute to the non-destructive test procedure, especially in determining homogeneity and the dimensions of the effective thickness of the structural walls (cores and layers) that have been installed in the field quickly, cheaply, accurately, and briefly.
SAVUNMA HARCAMALARI, İŞSİZLİK VE EKONOMİK BÜYÜME ARASINDAKİ NEDENSELLİK İLİŞKİLERİNİN ANALİZİ: TÜRKİYE ÖRNEĞİ
Authors: ÖZEN ATABEY Aslı , KARAKUŞ Mustafa
Published: December 2022

Savunma harcamaları ülke güvenliği için zorunlu olarak nitelendirilmekle birlikte ekonomik büyüme, istihdam gibi toplum refahını belirleyen değişkenleri de etkileyebilmektedir. Bu bağlamda savunma harcamalarının, söz konusu değişkenler üzerindeki olası etkilerinin ortaya konması, alan yazınındaki ihtiyaçtan ve toplum refahı açısından oldukça önem arz etmektedir. Nitekim bu çalışmanın amacı savunma harcamaları ile ekonomik büyüme ve işsizlik arasındaki nedensellik ilişkisini Türkiye ekonomisine yönelik olarak ekonometrik yöntemlerle incelemektir.
1988-2020 yılları arasındaki süreçte Türkiye’deki savunma harcamaları, işsizlik ve ekonomik büyüme değişkenlerine ait yıllık veriler kullanılarak yapılan çalışmada, Toda - Yamamoto (1995) Nedensellik Testi uygulanmıştır. Yapılan ekonometrik uygulama neticesinde, savunma harcamaları ve ekonomik büyüme arasında çift taraflı bir neden-sonuç ilişkisi bulunduğu sonucuna ulaşılmıştır. Ayrıca işsizlikten savunma harcamalarına doğru olmasa da savunma harcamalarından işsizliğe doğru olmak üzere sadece tek yönlü bir nedensellik ilişkisi tespit edilmiştir. Çalışma kapsamında yapılan ekonometrik analizde ekonomik büyüme ile işsizlik arasındaki ilişki de araştırılmış ve ekonomik büyümeden işsizliğe, işsizlikten de ekonomik büyümeye doğru nedensellik ilişkisi olmadığına dair bulgulara ulaşılmıştır.
Mediation und Systemische Beratung: Was beides trennt
Authors: Nixdorf Philipp
Published: December 2022

Im Spektrum der Mediation Ausgabe 3/2022 erfolgte eine Darlegung der Gemeinsamkeiten von Mediation und Systemischer Beratung. Schnittstellen, verfahrensübergreifend geteilte Überzeugungen und Grundhaltungen sowie Konvergenzpotenziale wurden aufgezeigt. Es existieren allerdings auch einige Unterschiede zwischen beiden Verfahren. Sie zu kennen und in der Anwendung zu berücksichtigen, ist wichtig.
Der praktische Fall
Authors: Metzger Tilman , Robrecht Thomas
Published: December 2022

In Ausgabe 89 stellte Ihnen Tilman Metzger den Fall »Die heimliche Beziehung einer Leiterin« vor. Nun folgt seine »Auflösung«. Gleichzeitig lädt Sie Thomas Robrecht ein, sich zu überlegen, wie Sie im neuen Fall reagiert hätten. In diesem Fall geht es um eine Mediationsserie ohne größere Widerstände.
»Die Wissenschaft darf nicht verstummen«
Authors: Weißkopf Markus , Windmann Thomas
Published: December 2022

Seit der Coronapandemie nehmen (verbale) Attacken auf Wissenschaftler*innen zu, vor allem in den sozialen Medien. Immer mehr Menschen zweifeln Forschungsergebnisse an und sträuben sich vehement gegen angeratene Handlungskonsequenzen. Wie kann man diesen Entwicklungen entgegenwirken, um weiterhin eine qualitativ hochwertige Wissenschaftskommunikation zu gewährleisten? Markus Weißkopf, Geschäftsführer von Wissenschaft im Dialog, berichtet von einem groß angelegten neuen Projekt zur direkten Unterstützung von Wissenschaftler*innen und Wissenschaftskommunikator*innen.
IMPLEMENTASI LAYANAN INFORMASI DALAM MENINGKATKAN MANAJEMEN WAKTU PENGUMPULAN TUGAS SELAMA PEMBELAJARAN DARING DI MAS SINAR ISLAMI BINGAI KEC. WAMPU KAB. LANGKAT
Authors: Dani Ismay
Published: December 2022

Tujuan dari penelitian ini untuk mengetahui 1) Bagaimana manajemen waktu pengumpulan tugas selama pembelajaran daring di MAS Sinar Islami Bingai Kec. Wampu Kab. Langkat, 2) Bagaimana keberhasilan implementasi layanan informasi dalam meningkatkan manajemen waktu pengumpulan tugas selama pembelajaran daring di MAS Sinar Islami Bingai Kec. Wampu Kab. Langkat, 3) Apa saja faktor pendukung guru bimbingan dan konseling dalam meningkatkan manajemen waktu pengumpulan tugas selama daring di MAS Sinar Islami Bingai.Jenis penelitian ini adalah penelitian kualitatif dengan menggunakan prosedurpengumpulan data berupa observasi, wawancara, dan dokumentasi. Teknis analisis yang digunakan dalam penelitian ini mereduksi data, penyajian data, dan memberi kesimpulan.Setelah dilakukan penelitian diperoleh hasil bahwa: implementasi layanan informasi dalam meningkatkan manajemen waktu pengumpulan tugas selama pembelajaran daring di MAS Sinar Islami Bingai Kec.Wampu Kab.Langkat sudah terlaksana dengan baik, namun dalam hal memanajemen waktu pengumpulan tugas menunjukkan bahwa tidak semua peserta didik menerapkan apa yang sudah disampaikan oleh guru BK.Kata Kunci : Layanan Informasi, Manajemen Waktu, Pengumpulan Tugas, Pembelajaran Daring