bluuebunny/crossref_metadata_2025 huggingface dataset:
Surgery on the C3-4 Level and the Presence of Ligamentum Flavum Hypertrophy Increases the Risk of 30-Day Reoperation Rate After Anterior Cervical Discectomy and Fusion
Authors: Shin Hong Kyung , Jang Sun Woo , Park Jin Hoon
Published: September 2024

BACKGROUND AND OBJECTIVES:

Cervical myelopathy caused by C3-4 level degeneration often exhibits different characteristics after anterior cervical discectomy and fusion (ACDF) than other cervical levels. This study compared the outcomes of C3-4 ACDF with surgeries at other levels and identified risk factors of 30-day reoperation after ACDF.

METHODS:

We retrospectively analyzed patients who underwent ACDF for degenerative cervical disease from 2018 to 2023. The patients were divided into 2 groups based on the level of surgery: C3-4 and non–C3-4 groups. Radiological outcomes, including cervical alignment and range of motion (ROM), were analyzed. Clinical outcomes were assessed with patient-reported outcomes and the rates of 30-day reoperation and complications after ACDF. Patient-reported outcomes included visual analog scale for neck pain, visual analog scale for arm pain, and modified Japanese Orthopedic Association scores. Risk factors of 30-day reoperation were assessed.

RESULTS:

Of 259 patients, 74 (28.6%) and 185 (71.4%) were in the C3-4 and non–C3-4 groups, respectively. The C3-4 group exhibited lower C2-7 ROM (P = .019), higher C3-4 ROM (P = .015), and greater C3-4 %ROM (P = .014). The C3-4 group demonstrated lower preoperative and 1-month postoperative modified Japanese Orthopedic Association scores (P < .001; P < .001, respectively). The rate of 30-day reoperation was significantly higher in the C3-4 group (9.5%) compared with the non–C3-4 group (2.2%) (P = .014). In addition, C3-4 surgical level (odds ratio = 4.99, P = .034) and ligament flavum hypertrophy (odds ratio = 5.84, P = .018) were identified as independent risk factors of 30-day reoperation after ACDF.

CONCLUSION:

Surgery on C3-4 level showed a higher risk of 30-day reoperation than other levels. It is likely due to C3-4 surgical level, and ligament flavum hypertrophy contributes to cord compression, particularly in the unstable early postoperative period.
Η επίδραση του παιχνιδιού και των θεατροπαιδαγωγικών τεχνικών στην ανάπτυξη δεξιοτήτων προσωπικής ασφάλειας σε παιδιά προσχολικής ηλικίας με και χωρίς αναπτυξιακές διαταραχές
Authors: Δάμπα Αθανασία
Published: September 2024

Σκοπός της παρούσας μελέτης ήταν η αξιολόγηση της ικανότητας παιδιών προσχολικής ηλικίας να αναγνωρίζουν και να αντιδρούν σε ενδεχόμενους κινδύνους από άγνωστα άτομα, καθώς και η εφαρμογή προγράμματος παρέμβασης για τη βελτίωση αυτών των δεξιοτήτων. Στην έρευνα συμμετείχαν 865 παιδιά προσχολικής ηλικίας, από τα οποία τα 555 παιδιά αποτέλεσαν την ομάδα ελέγχου, ενώ τα 310 αποτέλεσαν την ομάδα παρέμβασης. Σε όλα τα παιδιά έγινε αξιολόγηση των δεξιοτήτων προσωπικής ασφάλειας μέσω ενός τεστ (White et al., 2018), το οποίο σχεδιάστηκε για να αξιολογεί την ικανότητα των παιδιών να εφαρμόζουν γνώσεις συμπεριφοράς αυτοπροστασίας μέσω μιας ρεαλιστικής δοκιμασίας. Η ρεαλιστική δοκιμασία είχε τη μορφή ενός κοινωνικού πειράματος κατά την οποία αξιολογήθηκε η προθυμία των παιδιών να ακολουθήσουν μία άγνωστη γυναίκα που προσπάθησε να τα δελεάσει. Έπειτα, όλα τα παιδιά αξιολογήθηκαν με τη μορφή συνέντευξης για τις γνώσεις τους σχετικά με τις βασικές δεξιότητες αυτοπροστασίας (Children’s Safety Knowledge and Skills Questionnaire, Kraizer, 1986), αλλά και τις γνώσεις τους σχετικά με υποθετικά επικίνδυνες καταστάσεις (“What If” Situations Test, Wurtele et al., 1998). Από τα αποτελέσματα φάνηκε ότι στην αρχική ρεαλιστική δοκιμασία, το 88% πήρε το γλυκό που πρόσφερε η άγνωστη γυναίκα και το 78% δέχτηκε να την ακολουθήσουν στο αυτοκίνητο. Μετά την αξιολόγηση των αρχικών γνώσεων και των αντιδράσεων τους σε προκλητικές καταστάσεις, η ομάδα παρέμβασης παρακολούθησε ένα βιωματικό πρότυπο πρόγραμμα αφήγησης κλασικών παραμυθιών σε συνδυασμό με θεατροπαιδαγωγικές τεχνικές και παιχνίδια, διάρκειας 14 εβδομάδων και συχνότητας 3 φορές εβδομαδιαίως, για την αντιμετώπιση των κινδύνων. Μετά την ολοκλήρωση της παρέμβασης, παρατηρήθηκε σημαντική βελτίωση στην ικανότητα των παιδιών να αναγνωρίζουν κινδύνους και να αντιδρούν αποτελεσματικά σε πιθανές απειλές. Η προσέγγιση βιωματικής μάθησης αποδείχθηκε αποτελεσματική, παρέχοντας πρακτικές δεξιότητες αυτοπροστασίας στα παιδιά, βελτιώνοντας την ασφάλειά τους σε ενδεχόμενους κινδύνους.
Psychosocial well-being needs of alcohol/drug sufferers and therapeutic architectural solutions in rehabilitation centre, Nigeria: a cross-sectional study
Authors: Ekhaese Eghosa , Ezeora Ifeanyi
Published: September 2024

Background In a rehabilitation centre designed for drug and alcohol recovery, the therapeutic environment may enhance the psychosocial well-being of sufferers and facilitate a speedy recovery. This study aims to investigate the psychosocial well-being needs (PWNs) of users in an alcohol and drug rehabilitation centre (ADRC) and how therapeutic architectural solutions (TASs) can promote a healing environment through design. Methods The study employed a mixed research method (qualitative and quantitative). The research strategy was a case study of four rehabilitation centres in Nigeria’s busiest cities; Lagos, Abuja, Port Harcourt, and Enugu. Data were collected via survey questionnaires, an in-depth interview guide, an observation guide, and a checklist of TACs in a healthcare facility. We first investigated what the PWNs of alcohol and drug sufferers (ADSs) are, then identified the therapeutic architectural components (TACs) of an ADRC, before determining what effect TACs have on the recovery process of substance abuse patients. Results The findings identify eight PWNs and nine TACs essential in an ADRC. The result indicates that TACs have a significant effect on the recovery process of ADSs. However, based on the study results, a framework (framework here refers to using an intelligent and sensitive conceptual design structure as a standard guide for the building archetype rehabilitation facility, which supports mental health service delivery) may be recommended for rehabilitation facilities with TASs for Substance Abuse Disorder (SUD). Conclusion The study result presents a correlation between ADSs’ recovery rates and a well-designed therapeutic environment. So, there is a need for evidence-based design (EBD) of rehabilitation centres with full compliments of a therapeutic architectural environment and integration of mental health services into routine care in sub-Saharan Africa. Limitations include that analyses were cross-sectional and thus may not deduce causal directions, and the authors based the result on self-report.
Metagenome quality metrics and taxonomical annotation visualization through the integration of MAGFlow and BIgMAG
Authors: Yepes-García Jeferyd , Falquet Laurent
Published: September 2024

Background Building Metagenome–Assembled Genomes (MAGs) from highly complex metagenomics datasets encompasses a series of steps covering from cleaning the sequences, assembling them to finally group them into bins. Along the process, multiple tools aimed to assess the quality and integrity of each MAG are implemented. Nonetheless, even when incorporated within end–to–end pipelines, the outputs of these pieces of software must be visualized and analyzed manually lacking integration in a complete framework. Methods We developed a Nextflow pipeline (MAGFlow) for estimating the quality of MAGs through a wide variety of approaches (BUSCO, CheckM2, GUNC and QUAST), as well as for annotating taxonomically the metagenomes using GTDB-Tk2. MAGFlow is coupled to a Python–Dash application (BIgMAG) that displays the concatenated outcomes from the tools included by MAGFlow, highlighting the most important metrics in a single interactive environment along with a comparison/clustering of the input data. Results By using MAGFlow/BIgMAG, the user will be able to benchmark the MAGs obtained through different workflows or establish the quality of the MAGs belonging to different samples following the divide and rule methodology. Conclusions MAGFlow/BIgMAG represents a unique tool that integrates state-of-the-art tools to study different quality metrics and extract visually as much information as possible from a wide range of genome features.
Real Customization or Just Marketing: Are Customized Versions of Generative AI Useful?
Authors: Garrido-Merchán Eduardo C. , Arroyo-Barrigüete Jose Luis , Borrás-Pala Francisco , Escobar-Torres Leandro , Martínez de Ibarreta Carlos , Ortíz-Lozano Jose María , Rua-Vieites Antonio
Published: September 2024

Abstract* Background Large Language Models (LLMs), as in the case of OpenAITM ChatGPT-4TM Turbo, are revolutionizing several industries, including higher education. In this context, LLMs can be personalised through a fine-tuning process to meet the student demands on every particular subject, like statistics. Recently, OpenAI launched the possibility of fine-tuning their model with a natural language web interface, enabling the creation of customised GPT versions deliberately conditioned to meet the demands of a specific task. Methods This preliminary research aims to assess the potential of the customised GPTs. After developing a Business Statistics Virtual Professor (BSVP), tailored for students at the Universidad Pontificia Comillas, its behaviour was evaluated and compared with that of ChatGPT-4 Turbo. Firstly, each professor collected 15-30 genuine student questions from “Statistics and Probability” and “Business Statistics” courses across seven degrees, primarily from second-year courses. These questions, often ambiguous and imprecise, were posed to ChatGPT-4 Turbo and BSVP, with their initial responses recorded without follow-ups. In the third stage, professors blindly evaluated the responses on a 0-10 scale, considering quality, depth, and personalization. Finally, a statistical comparison of the systems’ performance was conducted. Results The results lead to several conclusions. Firstly, a substantial modification in the style of communication was observed. Following the instructions it was trained with, BSVP responded in a more relatable and friendly tone, even incorporating a few minor jokes. Secondly, when explicitly asked for something like, “I would like to practice a programming exercise similar to those in R practice 4,” BSVP could provide a far superior response. Lastly, regarding overall performance, quality, depth, and alignment with the specific content of the course, no statistically significant differences were observed in the responses between BSVP and ChatGPT-4 Turbo. Conclusions It appears that customised assistants trained with prompts present advantages as virtual aids for students, yet they do not constitute a substantial improvement over ChatGPT-4 Turbo.
Systematic Literature Review of Disseminating Health Information to BIPOC Communities
Authors: Kelly Damien , Ostovar-Kermani Tiffany G.
Published: September 2024

Purpose This study aims to systematically review the literature to examine best practices for disseminating health information and strategies useful for advancing equitable health outcomes in communities of Black, Indigenous, and People of Color (BIPOC). Methods Databases such as Science.gov, Education Resources Information Center (ERIC), Social Science Research Network, and CHAT AI were searched using terms like “health promotion,” “information dissemination/methods,” “minority communities,” “urban health,” “health education/methods,” and “health promotion/methods.” The search focused on qualitative, quantitative, and mixed-methods studies conducted between January 1, 2005, and December 31, 2023. An academic expert evaluated the manuscripts for quality. Dissemination methods were categorized based on cultural, linguistic, and sociodemographic characteristics. Results/Expected results Out of 4,726 articles identified, 23 were included in the full review. The study found that the most effective methods for disseminating health information involved direct community interaction using versatile communication strategies. Real-time engagement and accessibility to public health experts increased community trust and participation. Narrative storytelling, focus groups, workshops, and the use of technology for visual representation were particularly effective. Major obstacles included the lack of stakeholder interaction, language barriers, cultural, educational, and generational differences, and limited funding for human resources. The unavailability of information from previous research also caused frustration among decision-makers. Conclusion Effective engagement with BIPOC communities requires diverse communication methods. Involving community members in selecting settings, language, cultural activities, and other specific aspects helps non-community stakeholders understand evidence-based best practices for health information dissemination, thereby improving healthcare outcomes. Implications This comprehensive literature review enhances understanding of evidence-based best practices for disseminating health information to BIPOC communities. The findings provide valuable insights for policymakers, healthcare providers, community organizations, and researchers to develop targeted and effective health communication strategies.
Current State and Development Trends of Agricultural Consumer Cooperation
Authors: Burlakov Vladimir
Published: September 2024

Today, small forms of management in the Russian agro-industrial complex occupy a significant share in the structure of producers for certain groups of agricultural raw materials and food. Institutional transformations that have taken place over decades in the agro-industrial complex have shown the viability of such a form of organization as agricultural cooperation. The advantages that determine the competitiveness of cooperation include reducing transaction costs, economies of scale, increasing the share of rural producers in the final price of products, etc. Modern socio-economic trends dictate new conditions for the formation of food chains and the participation of economic entities in them. In this connection, there is an urgent need to analyze trends in the development of agricultural consumer cooperation. This will make it possible to determine strategic directions for development and justify relevant measures of state support for both small business forms themselves and the cooperative form of their organization. The purpose of the study is to comprehensively analyze and substantiate the development trends of the institution of agricultural consumer cooperation, as the most important component of ensuring food security in Russia in modern conditions. Achieving this goal involves the use of general scientific methods of cognition (historical and logical, comparative and system-structural) and traditional methods of economic analysis. The trends in the development of the Institute of Agricultural Consumer Cooperation have been studied. A comprehensive analysis of the competitive advantages and weaknesses of small business forms in the agro-industrial complex was carried out. The potential for growth of the institution of agricultural consumer cooperation in the conditions of transformation of the socio-economic space has been identified. The experience of supporting agricultural cooperatives in the constituent entities of the Russian Federation was studied. Measures of state support for the development of this institution that are relevant to current trends in economic development are substantiated. The results of the study and the conclusions drawn on their basis will be useful for supporting management decisions in the field of development of the agro-industrial complex, increasing the efficiency of planning and implementing state support for the small business sector in the agro-industrial complex
Alternative Forms of Investment at the Present Stage
Authors: Yudina O.
Published: September 2024

e article is devoted to the marginal use of alternative investment forms: gold, precious metals, coins and diamonds at the current stage, as well as their detailed characteristics in conditions of high volatility and uncertainty of financial markets. The study reveals the dynamics, main advantages, disadvantages and extrapolar trends of the above-listed forms of investment.

The article focuses on the profitability of the main financial instruments with significant risks and economic unpredictability for private investors, and its correlation with official inflation is presented.

In order to hedge and diversify risks, a comparative analysis of the main financial indicators of the market and an algorithm for the profitability of a conditional balanced portfolio of a private investor are presented.

The final results of the study provide a description of the fundamental factors of the growth in demand for diamonds in the long term and prove the effectiveness and convenience of this instrument.
The affective temperaments as a prognostic factor in the course of alcohol addiction – a key to enhance diagnoses and therapy?
Authors: Podlecka Marlena , Nowakowska-Domagała Katarzyna , Czarnecki Jan , Mokros Łukasz
Published: September 2024

The paper outlines the role of affective temperaments, as defined by Akiskal, in the development and maintenance of alcohol use disorders with a particular focus on the clinical course of addiction.
Among affective temperaments, a cyclothymic temperament seems to play a key role in the development and maintenance of alcohol use disorders, and have the greatest influence on the clinical course of addiction. A high cyclothymic score is associated with inter alia an earlier onset of drinking and alcohol dependence, a negative course of alcohol dependence, relapse and alcohol craving. The structure of affective temperaments is also a predictor of suicidal behavior and drug addiction in the alcohol addict population.
Interest has been growing regarding the role of affective temperament in the development and course of alcohol dependence; however, further research in this area is needed. An understanding of the temperamental determinants of alcohol dependence in the affective dimension may significantly support diagnostic and therapeutic procedures. Affective temperament profile may be suggestive of alcohol use disorders and may be a primary prognostic factor of craving and relapse, potential suicide, treatment motivation and the co-occurrence of drug dependence among patients with alcohol use disorder.
Exploring the Therapeutic Potential of Sodium Butyrate in Irritable Bowel Syndrome. A Literature Review
Authors: Miga-Orczykowska Nadia , Lemieszek Paulina , Sajkiewicz Ilona , Rudnicka Katarzyna
Published: September 2024

Introduction and purpose
Irritable bowel syndrome (IBS) is a prevalent digestive condition marked by symptoms like abdominal discomfort, bloating, and irregular bowel movements. Sodium butyrate, a short-chain fatty acid recognized for its anti-inflammatory effects and benefits to gut health, has gained attention as a potential treatment for IBS. This review seeks to assess the existing research on the effectiveness and safety of sodium butyrate in managing IBS.
Material and methods
This work was based on a review of the literature available on PubMed. We included studies corresponding to the keywords: sodium butyrate, irritable bowel disease, butyric acid.
Results
Research has shown that sodium butyrate supplementation significantly alleviated abdominal pain, bloating, and overall IBS symptoms compared to a placebo. Notable improvements were seen in both visceral pain sensitivity and gut permeability. Furthermore, combining sodium butyrate with probiotics may offer additional benefits. The treatment was generally well-tolerated, easily accessible, and cost-effective.
Conclusion
Sodium butyrate shows promise as a therapeutic option for managing IBS, with studies indicating its effectiveness in reducing symptoms and enhancing gut health. However, more extensive, well-structured clinical trials are required to validate these results, determine optimal dosage, and assess long-term safety and efficacy.
The role of prolactin levels in metabolic syndrome: a systematic review
Authors: Korta Karolina , Szeliga Anna , Oluszczak Karolina , Szostak Agata , Dyląg Liliana , Wawszkowicz Konrad , Szopińska Kinga , Śmigielska-Mikołajczyk Maria Janina , Łowicka Weronika , Graca Magdalena
Published: September 2024

Introduction and purpose: Prolactin is primarily associated with lactation and gonadal function, but it also has metabolic effects. Recent research shows prolactin's role in food intake, body weight, glucose, and lipid profile. Both low and excessive prolactin levels can lead to metabolic dysfunctions such as metabolic syndrome, type 2 DM, and dyslipidemia. Dopamine agonists, like cabergoline, used to treat hyperprolactinemia, may help balance metabolic homeostasis, likely due to their effect on prolactin. This study aims to synthesize current research on prolactin's metabolic effects, focusing on metabolic syndrome.State of knowledge: Metabolic syndrome is a cluster of dysfunctions like central obesity, atherogenic dyslipidemia, hypertension, and insulin resistance. It increases the risk of diabetes and cardiovascular diseases, affecting a quarter of the European population. Different combinations of metabolic syndrome components require various treatment approaches. New research focuses on prolactin and dopamine agonists in its pathogenesis and treatment.Materials and methods: This literature review is based on PubMed materials using keywords “prolactin,” “hyperprolactinemia,” “hypoprolactinemia,” “metabolic syndrome,” “diabetes mellitus,” “obesity.”Conclusions: This study highlights prolactin's importance in metabolic homeostasis, finding a positive correlation between both low and high prolactin levels and metabolic syndrome. However, gender differences and the pathogenesis of metabolic disorders should be further explored.
Complicated symptomatology and diagnosis of Creuzfeld-Jakob disease on a basis of clinical case
Authors: Jurga Marta , Kuśmierczyk Katarzyna , Karkos Patrycja , Gruszczyńska Hanna , Kuderska Natalia , Jurga Kacper , Okowińska Ewa , Cieślik Aleksandra , Wojtyła Klaudia , Lambrinow Jakub
Published: September 2024

Creutzfeldt-Jakob disease (CJD) is a rare condition. In this study we describe the diagnosis of the disease in a 73-year old female, presenting dementia. Diagnostic tests unveiled characteristic features of CJD. The diagnosis of CJD was confirmed. It is important to always take into consideration the diagnosis of CJD in the diagnostic process of dementia.
Purpose: The aim of this scientific paper is to present symptoms and diagnostic methods of Creutzfeldt-Jakob disease on the basis of a clinical case.
Review Methods: We conducted our study as a literature review based on information gathered from PubMed, Embase, GoogleScholar using combinations of the following. As a part of study, we also present a case description from our materials from clinical practice.
role of butyric acid in the human body - review
Authors: Krawczuk vel Walczuk Julia , Baran Joanna , Sobczyk Maciej , Słaboń Małgorzata , Pasztelan Małgorzata , Pulikowski Jarosław , Garbacz Karolina , Maciąg Maria , Muca Aleksandra , Marczak Aleksandra
Published: September 2024

Wprowadzenie i cel: Kwas masłowy jest jednym z najważniejszych krótkołańcuchowych kwasów tłuszczowych (SCFA) wytwarzanych w ludzkim jelicie grubym. Celem tego artykułu jest podkreślenie jego funkcji i potencjalnych zastosowań w praktyce klinicznej. Analizując wyniki badań i publikacje naukowe, podejmiemy próbę wyjaśnienia znaczenia kwasu masłowego w funkcjonowaniu ludzkiego ciała.
Cel pracy: Celem niniejszej pracy było przedstawienie wyników badań naukowych dotyczących funkcji i zastosowania kwasu masłowego w medycynie.
Materiały i metody: Niniejszy przegląd opiera się na analizie materiałów pochodzących z bazy PubMed i różnych artykułów naukowych, wykorzystujących takie słowa kluczowe, jak „kwas masłowy”, „maślan”, „nieswoiste zapalenie jelit”, „odporność”, „mikrobiota jelitowa” i „krótkołańcuchowe kwasy tłuszczowe”.
Opis stanu wiedzy: Mikrobiota jelitowa jest przedmiotem badań naukowych od wielu lat, jednak znaczenie jej produktów metabolicznych, w tym kwasu masłowego, jest dopiero teraz w pełni zrozumiane. Obecny stan wiedzy daje nadzieję na stosowanie kwasu masłowego w takich schorzeniach jak choroby zapalne jelit, co potwierdzają liczne badania. Przeciwzapalne właściwości tego metabolitu bakterii jelitowych sugerują również potencjalne korzyści w chorobach neurodegeneracyjnych i sercowo-naczyniowych, co podkreślają cytowane tutaj prace naukowe, które potwierdzają takie zastosowania .
Wnioski : Kwas masłowy, jako produkt metaboliczny mikrobiomu jelitowego, ma potencjał, aby stać się znaczącym suplementem w różnych dziedzinach medycyny. Niniejszy przegląd, który bada jego działania i zastosowania, dostarcza wglądu w jego możliwe funkcje i daje nadzieję na przyszłe opcje terapeutyczne.
Early diagnosis, effective treatment: modern approaches to the management of ectopic pregnancies
Authors: Żydek Ada , Ciułek Urszula , Bilska Wiktoria , Zduńczyk Wiktoria , Dobosz Anna , Dubińska Michalina , Paduch-Jakubczyk Wiktoria
Published: September 2024

Purpose of research: The aim of this article is to provide an overview of the diagnosis and management of atypical ectopic pregnancy, with particular reference to pregnancy in the cesarean scar. The importance of early detection and medical intervention will be described, as well as the impact of advanced diagnostic techniques and modern treatments on the curability of patients.This article aims to provide valuable insights into the development of effective strategies for the diagnosis, treatment and prognosis of ectopic pregnancy.
State of knowledge: Ectopic pregnancies account for 1-2% of all pregnancies, with the majority (90%) occurring in the fallopian tube. Less commonly, they present as ovarian, cervical or abdominal pregnancies. Advances in diagnosis and treatment have made it possible to identify rare forms such as cesarean scar pregnancy (0.15% of all pregnancies), interstitial pregnancy and recurrent ectopic pregnancy on tubal remnants. Techniques such as transvaginal ultrasound (TVS), MRI and laparoscopy have the potential to improve diagnostic accuracy and treatment outcomes. Modern interventions such as transvaginal natural orifice transluminal endoscopic surgery (vNOTES) and methotrexate have shown promise in terms of safety and efficacy.
Conclusions: Ectopic pregnancy and its complications have a significant impact on the psycho-physical health of patients, requiring ongoing research to improve diagnostic and therapeutic methods. Future studies should focus on long-term outcomes and the coordination of multidisciplinary medical care to further improve diagnosis and treatment.
Existence of positive solution for a class of quasilinear Schrödinger equations with potential vanishing at infinity on nonreflexive Orlicz-Sobolev spaces
Authors: Da Silva Lucas , Souto Marco A. S.
Published: September 2024

In this paper we investigate the existence of positive solution for a class of quasilinear problem on an Orlicz-Sobolev space that can be nonreflexive
$$
- \Delta_{\Phi} u +V(x)\phi(|u|)u= K(x)f(u)\quad\mbox{in } \mathbb{R}^{N},
$$
where $ N \geq 2 $, $ V, K $ are nonnegative continuous functions and $f$ is
a continuous function with a quasicritical growth.
Here we extend the Hardy-type inequalities presented in \cite{AlvesandMarco} to nonreflexive Orlicz spaces. Through inequalities together with a variational
method for non-differentiable functionals we will obtain a ground state solution. We analyze also the problem with $V=0$.
The limiting behavior of solutions to p-Laplacian problems with convection and exponential terms
Authors: De Araujo Anderson L. A. , Ercole Grey , Vargas Julio C. Lanazca
Published: September 2024

We consider, for $a,l\geq1$, $b,s,\alpha> 0$, and $p> q\geq1$, the
homogeneous Dirichlet problem for the equation $-\Delta_{p}u=\lambda
u^{q-1}+\beta u^{a-1}\left\vert \nabla u\right\vert ^{b}+mu^{l-1}e^{\alpha
u^{s}}$ in a smooth bounded domain $\Omega\subset\mathbb{R}^{N}$. We prove
that under certain setting of the parameters $\lambda$, $\beta$ and $m$ the
problem admits at least one positive solution. Using this result we prove that
if $\lambda,\beta> 0$ are arbitrarily fixed and $m$ is sufficiently small, then
the problem has a positive solution $u_{p}$, for all $p$ sufficiently large.
In addition, we show that $u_{p}$ converges uniformly to the distance function
to the boundary of $\Omega$, as $p\rightarrow\infty$. This convergence result
is new for nonlinearities involving a convection term.
Multiplicity of 2-nodal solutions of the Yamabe equation
Authors: Ortiz Jorge Dávila , González Héctor Barrantes , Lima Isidro H. Munive
Published: September 2024

Given a closed Riemannian manifold $(M,g)$, we use the gradient flow method and Sign-Changing Critical Point Theory to
prove multiplicity results for $2$-nodal solutions of a subcritical non-linear equation on $(M,g)$, see \eqref{yam-nodal-1} below. If $(N,h)$ is a closed Riemannian manifold of constant positive scalar curvature our result gives multiplicity results for the Yamabe-type equation on the
Riemannian product $(M\times N , g + \ve h )$, for $\ve > 0$ small.
p(x)-biharmonic equations involving (h,r(x))-Hardy singular coefficients with no-flux boundary conditions
Authors: Liu Jian , Zhao Zengqin
Published: September 2024

In this article, we investigate $p(x)$-biharmonic equations involving two kinds of different Hardy potentials, in which the $r(x)$-Hardy potentials are seldom mentioned in previous papers. New criteria for the existence of generalized solutions are reestablished when the nonlinear terms satisfying appropriate assumptions.
The results are based on variational methods and the theory of variable exponent Sobolev spaces.
Evaluación del conocimiento tecnológico pedagógico del contenido (TPACK) entre los profesores en formación: modelo de medición Rasch
Authors: Komarudin Komarudin , Suherman Suherman
Published: September 2024

La creciente importancia de integrar la tecnología en los entornos educativos ha subrayado la importancia del Conocimiento Tecnológico del Contenido Pedagógico (TPACK) para una enseñanza eficaz en el siglo XXI. Sin embargo, muchos futuros docentes enfrentan desafíos para acceder y utilizar de manera competente las nuevas tecnologías en sus prácticas docentes. La literatura existente carece de un examen exhaustivo de los aspectos empíricos de los instrumentos TPACK y su aplicabilidad en diversos entornos y niveles educativos, particularmente en contextos no occidentales. Esta investigación tuvo como objetivo evaluar y comparar TPACK entre profesores en formación en Indonesia. Una muestra diversa de 405 futuros docentes indonesios de diferentes disciplinas participó completando un cuestionario TPACK en línea. Se utilizaron análisis factorial confirmatorio y el modelo de Rasch para validar el cuestionario, demostrando un modelo bien ajustado consistente con su marco teórico y un ajuste satisfactorio para individuos y ítems. La evaluación de TPACK entre profesores de educación primaria, preescolar y matemáticas en formación reveló un desempeño superior por parte de los profesores de educación primaria en formación. Las sólidas propiedades psicométricas lo hacen adecuado para explorar TPACK. Esta investigación sienta las bases para una mayor investigación de las dimensiones empíricas de TPACK en diversos contextos educativos.
A Case Study on the Social Skill Training in Psychiatric Mental Health Nursing
Authors: Lee Kwang Ja , Kim Gyung Hee , Park Jeung Suk , Choe Kwi Sun
Published: September 2024

Recently as psychiatric mental health nursing focuses on the psychiatric patients* social rehabilitation after discharging, we can see the trend of more practical and substential rehabilitation therapies being developed and improved.Psychiatric client experience deterioration of social functioning, deficits in social skills and dysfunctional inter — relationships. Those who has mental disability spend the rest of their life suffering from their handicap. Even after the discharge, lack of social skills and difficulties in adjusting to reality, draw them act to relapse or rehospitalization. Thus appropriate rehabilitation program will improve social adjustment increase self-esteem develop positive interpersonal relationship and further more it will prevent them from regression.The purpose of this study is to verify the effectiveness of social skills training program in improving the psychiatric client* social functioning. To serve the purpose of the study outpatient with OPD treatment and community psychiatric patient were selected to test effect of social skill training.The effect of social skill traing will be evaluated by comparity the consequences of relationship change, social behavior, positive and negative syndrome before and after the experiment. Also cases will be based on the result, the cases will be analyzed individually to prove the case changing scores.The following are these results of the analysis of the 2 cases.1. Interpersonal relationship score of case 1 was biggest incresed from 56 score to 88 score by 32 score. Case 2 showed the increase from 55 score to 73 score. Both of these result was possible due to effective role play and feedback.2. Social behavior score improved from 67 score to 89 score by social skills training for case 1. For case 2, Social behavior score improved from 61 score to 80 score social skill training was merely focused on correcting non-verbal communication skill (ex : eye contact) and the results showed a great deal of improvement.3. The positive and negative syndrome score of case 1 decreased from 50 score to 36 score by 14 score.Case 2 also decreased from 78 to 60 score by 18 score. Case showed difficulties in expressed negative feeling (ex : anger) but improved after the training.Therefore, regardless of individual differences, there were improvements in relationship change, social behavior, and positive & negative syndrome.In other words, limitations of this program were first, the short program practice period, secondly, lack of case.Based on the results of this study, it is concluded that the social skills training program is a very valuable intervention method for psychiatric mental health nursing. Therefore if the studies, applied in actual situation, which based on this study were continuously conducted, it will contribute to psychiaric patient’ interpersonal relationship and social rehabilitation.
Behavior Modification Case of a 6-year Old Girl with Disruptive Behaviors
Authors: Joo Hye Joo
Published: September 2024

The study showed the process of behavior modification of a 6—year old girl with disruptive behaviors, admitted to child-adolescent psychiatry ward. The behavior problems which were observed for a week in the ward were, 1. Without reason, hitting and biting other children and therapists for 10 -12 times a day.2. Rejeccting meals and throwing away the tray for 2—3 times a day.3. Rejecting the drug with aggressive behaviors to therapists.4. Rejecting to wash her face and brush her teeth with aggressive behaviors to therapists.5. Taking away other children’s goods without con sent for 5—6 times a day.Through the application of behavior modification program, reinforcement and punishment were given simply, definitely.So the adaptive behaviors improved and maladap tive behaviors decreased.The outcomes were, 1. The hitting and biting behavior decreased for 1-2 times.2. The rejecting meals and throwing away the tray dissappeared.3. She took the medicine without aggressive behaviors.4. With a little prompt, she washed her face and brush her teeth.5. Taking away other’s thing decreased for 1—2 times.In addition,other positive behaviors increased.For example, she took care of the younger ones in the ward and she could do other activities of daily living.Finally, through the consistent B. M. program at home during admission period, her mother had confidence of controling her daughter’s behaviors.
Theory and Practice of Nursing - Logotherapy
Authors: Lee Jeong Ji
Published: September 2024

Nursing has its object such as human being. Human have an innate need for positive change and growth. Especially, psychiatric nurse as experts in communication and relationship with patients have to plant warmth and meaning of life in through the interpersonal relationship of encounter, sharing, and caring. By doing so, nurses have to make patients be existed with a comfort and peace.Psychiatric nursing has focused on the process of interpersonal relationship to maintain, improve, recover, and restore the mental health. This is very personal struggle to establish the relationship between nurse and patients. It is maintained and accomplished by a nurse, and called for techniques and means to establish this relationship effectively in short period.The purpose of this descriptive study was to understand and applicate to nurses as an effective nursing intervention that Nursing—Logotherapy developed and tested by the proceding study “The effect of Nursing-Logotherapy on the self-esteem, purpose in life and finding meaning, and hope of the patients of mental illness*.Nursing — Logotherapy based upon Travelbee’s five—step model of interpersonal relationship and includes three steps of Carkhuff and Gazda’s model-warmth, respect, empathy. In its 4th step of nursing activity, mainly activates Frankfs logo therapy and follows the solution — focused brief therapy of Kim-Berg. In its 5th final step, it includes the preparatory education to leave a hospital.
A Study of the Relationship Between Professional Self Concept and the Opinion, Attitudes Above the Specialization Regarding Korean Nurses
Authors: Kim Susie , Noh Choon Hee , Han Young Sook , Jeong Kum Hee
Published: September 2024

This study was conducted to find the level of Korean nurses’ professional self-concept and to validate the PSCNI tool. Also, we had a goal to understand the Korean nurses opinion and attitudes about nursing specialization.The research subjects were 1200 clinical nurses in Korea, who attended the academic conference of KNC on nursing specialization from March to November 1995.We used the tool of research developed from demographic items concerning opinions, attitudes on specialization and PSCNI (30iterns).Research findings were as followes : (1) The credibility of PSCNI was very high(Cronbach’s alpha=0.933211). The results of validity test showed that professional self concept consisted of 4factors: competence, satisfaction, confidence, empathy. These factors reflected 'caring’ as the core element of nursing. (2) The average item score of PSCNI was 3.02. This means that professionalism of Korean nurses has not yet been established. The high scoring items were U I don’t believe I am particularly empathic**, T think it is important to share emotions with patients 0 , “I feel more comfortable not getting too emotionally close to the people I work with”. This finding suggested the need to gain the skill of empathy in the clinical and educational setting. (3) The majority of subjects wanted to establish nursing specialization, which included 6types of Medical-Surgical nursing, MaternityChild nursing, Psychiatric — Mental health nursing, Geriatric nursing, and Community nursing. These 6types were presented by ICN. They think nursing specialization should be settled by the needs of clients first. (4) Resistered nurses should be calledw general nurse (GN) w , general nurses who completethe training courses in Anesthetics, Psychiatric — Mental health, and Home Care for one year, then receive the certificates issued by the government, called “certified nurse(CN) W . Those certified nurses who complete the specialized master of nursing science program, which includes advanced nursing the ory courses, clinical experiences, and research methodology should be called “advanced practice nurse(APN)". (5) There is no clear difference be tween opinion and attitudes of the standards and criteria of training institution, training period, whether or not the certification test, test supervising institution certificates. (6) There is a significant deference between PSCNI and the opinion and attitudes on nursing specialization. The nurses who had positive PSCNI revealed high motivation to be a CN, or APN and had a specific plan.In conclusion, to gain the professional self-con cept, nurses should be socialized continuously through role modeling in basic nursing education, clinical nursing and research.
Trend of Mental Health Nursing Research in Korea
Authors: Yang Soo , Lee Mi Hyoung , Yu Sook Ja
Published: September 2024

This study was conducted to examine research trends in psychiatric — mental health nursing in Korea. The data were collected from 221 theses published between January, 1962 and August, 1995 and included psychiatric patients, psychiatric hospi tal, community mental health, psychiatric nurses, or psychiatric nursing records. The results are following.1. The first thesis in the field of psychiatric — mental health nursing was published in 1968. There were 221 master's and doctoral theses from 27 colleges by 1995. Twenty two of the theses were doctoral ones from 6 nursing colleges. There were 16 theses only by 1980, yet the number increased to 93 in 1980’s. The number of theses sharply increased in 1990’s, when researchers adopted various scopes and methods of research. Accordingly, the number( 113) of theses published in recent 5 years was greater than the number(108) published between 1962 and 1990.2. Surveys (42.5%) and correlational studies (34.4%) were most prevalent and these research designs were mainly conducted before 1980. Quasi -experimental design was adopted after 1981 and it has been conducted more oftentimes in recent years.Qualitative study was reported after 1986 and the rate of thesis using this design increased rapidly between 1991 and 1995. 3. As for the subjects, healthy people were greatest, which were followed by patients, nurses, families of patients, and families of healthy people, in that sequence. According to the developmental stage of the subject, adults took most, followed by adolescents, the school-aged and the aged.4. The data were collected by using questionnaires most frequently (185 theses), followed by interviews, physiological measures, and obser vation. A variety of methods for data collection appeared as time passed by. Hospital were most prevalent place for data collection, followed by schools, and communities.5. Regarding measurement, general questionnaires were most frequently used(119 theses). Those variables measured are stress, burnout, mental health, anxiety, depression, physical status, family measures, use of drug, social support, activities in daily life , satisfaction, locus of control, personality, adjustment, self-concept, health beliefs, loneliness, coping strategies, etc. The physiological measures chosen were serum components, blood pressure, the amount of output, pulse rate, respiration.6. Most studies adopted quantitative method. As for data analyses, t - test was adopted in 150 theses, revealing the highest frequency. Other statistical methods used in the theses were ANOVA, percentages, correlation analysis, frequencies, chi-square test, etc. In particular, such inferential statistics as regression analyses, factor analyses, and ANOVA began to be used from late 1980’s, while nonparametric statistical method has been adopted since 1991. Qualitative research method was largely applied after 1991.
Enhancement of Mycelial Biomass Production and Bioactive Properties Related to Cosmeceuticals of Calocybe indica (Milky Mushroom) by Optimization of Submerged Culture Conditions
Authors:   Department of Microbiology, Faculty of Science, Kasetsart University, Bangkok 10900, Thailand, Vajrobol Natthawadee , Taengphan Weerasak ,   Expert Center of Innovative Herbal Products, Thailand Institute of Scientific and Technological Research, Pathum Thani 12120, Thailand, Teerapatsakul Churapa ,   Department of Microbiology, Faculty of Science, Kasetsart University, Bangkok 10900, Thailand
Published: September 2024

Calocybe indica or milky mushroom grown in submerged culture was investigated as a new source of antioxidants and anti-collagenase substances, and for its ability to inhibit three bacteria that trigger inflammatory acne, Cutibacterium acnes, Staphylococcus epidermidis, and S. aureus. To facilitate C. indica submerged cultivation and achieve high productivity, a three-level four-factor Box-Behnken design was utilized to find the optimal culture conditions for its mycelial biomass production. The model estimated the optimal conditions as 30 °C, a medium pH of 5.9, and incubation for 14 days under static culture, with results verifi ed by validation experiments. The optimal conditions gave mycelial biomass of 7.12 g/L, which is 5-fold higher than the original condition. This statistical method facilitated rapid identification and integration of key factors for C. indica high mycelial biomass production with significantly improved cosmeceutical properties in terms of antioxidant and antibacterial activities against acne-causing bacteria, especially C. acnes at 19-fold and 18-fold, respectively, compared to the original condition. An ethanolic extract derived from C. indica mycelia was nontoxic to human skin keratinocytes (HaCaT). These diverse functionalities indicate that the mycelial extract of C. indica may represent a promising source of bioactive substances for cosmeceutical applications.
Managing uterine artery pseudoaneurysm post-hysteroscopic surgery: Clinical insights and future directions
Authors: Cheng Chun-Han , Hao Wen-Rui , Cheng Tzu-Hurng
Published: September 2024

This editorial discusses the case report by Kakinuma et al , which details a rare occurrence of uterine artery pseudoaneurysm following hysteroscopic surgery. The case highlights diagnostic challenges and management strategies for this uncommon complication. The editorial explores the implications for clinical practice, emphasizing the importance of early recognition and appropriate intervention to prevent potential severe outcomes. Future research directions to increase the understanding and management of uterine artery pseudoaneurysm in similar clinical settings.
Revisiting tuberculosis as a cause of gastric outlet obstruction: Insights from a case report
Authors: Meng Jin , Zhang Li-Mei , Wang Zhi-Gang , Zhao Xiu , Bai Hai-Xia , Wang Ying , Chen De-Yu , Liu De-Long , Ji Cheng-Chun , Liu Yuan , Wang Lei , Li Bo-Yang , Yin Zhi-Tao
Published: September 2024

Gastroduodenal tuberculosis (GD-TB) is exceptionally rare. The clinical manifestations of gastrointestinal TB are diverse and non-specific, which makes diagnosis difficult, leading to delayed diagnosis and high mortality. As a peer-reviewer of World Journal of Clinical Cases , I would like to share my opinion on the article published by this journal. The patient had no family history of TB or contact with people with TB. Primary GD-TB presenting as gastric outlet obstruction and normal findings of thoracic computed tomography increased the difficulty of diagnosis and treatment in this patient. The diagnosis and treatment scheme of this typical case have reference value for the clinical treatment of GD-TB.
Butorphanol in epidural: Could this be the breakthrough solution for safe and effective labor analgesia that we've been waiting for?
Authors: Gupta Anju , Valecha Brinda , Gupta Nishkarsh
Published: September 2024

The authors have conducted a comprehensive investigation into the safety and effectiveness of butorphanol for epidural analgesia during labor. Their critical analysis of the paper and discussion of the technique's advantages and disadvantages provide a thorough understanding of the topic.