bluuebunny/crossref_metadata_2025 huggingface dataset:
Carrot hairy roots (Daucus carota L.) characterisation and optimisation for high β‐carotene extraction
Authors: Mai Nga Thi Phuong , Le Thi Van Anh , Nguyen Bao Chau , Le Nguyen Ha Trang , Do Quang Minh
Published: December 2022

Hairy roots are widely known as a biological system for the production of highly diverse biomolecules. β‐carotene – a precursor for vitamin A – is known to be an anti‐oxidant and anti‐gastric cancer and protection agent against cardiovascular disease, heart disease and stroke. β‐carotene has been chemically synthesised and consumed by humans. However, the chemical process often produces a by‐product that may be harmful to human health. Therefore, this study established a protocol to induce hairy roots (HRs) from a Vietnamese carrot variety and produce natural β‐carotene. The Rhizobium rhizogenes ATCC15834 harbouring Ri plasmid and a Vietnamese carrot variety were used as materials for genetic transformation and HR induction studies. The result showed that approximately 50 HR lines were obtained. Culture medium supplemented with 30 mg/L of sucrose that gave the highest biomass of HR was shown in carrot HR line 30, which had a doubling time of 6.5 days. The highest content of β‐carotene extraction, at 128 mg/100g hairy roots, was achieved with a ratio volume (v/v) of 2‐propanol and plant samples of 20:1, followed by two hours’ incubation with 2‐propanol at 60 °C. Our study reveals a highly efficient protocol for Vietnamese carrot hairy root establishment and multiplication. A very efficient protocol for β‐carotene extraction from the hairy root was established to produce natural β‐carotene that achieves the same β‐carotene quantity as that produced by normal roots. This study provides new insight into the production of high‐content and natural β‐carotene for therapeutic application.
Bio-oil synthesis from Botryococcus braunii by microwave-assisted pyrolysis
Authors: Ortiz Edixon Daniel , Budiman Arief , Cahyono Rochim Bakti
Published: December 2022

Microalgae have proven to be a promising resource in renewable energy search; Products such as bio-oils could contribute to the replacement of petroleum. The objective of this investigation is to determine the decomposition mechanism, obtain the kinetic reaction, as well as evaluate the potential to obtain microalgae bio-oil through microwave-assisted pyrolysis (MAP). MAP is a new thermochemical conversion from biomass to bio-oil that is faster, efficient, controllable, and flexible, compared to conventional pyrolysis, rapid pyrolysis, or instant pyrolysis. As raw material in this experiment, Indonesian microalgae, Botryococcus braunii was used. The investigation focused on the temperature effect (100-300 °C) and the residence time (10-30 min); a modified microwave oven was used with a power of 900 W. Hexane was used for the extraction of bio- oil. The bio-oil composition was measured with chromatography of mass spectrometry gas (GC-MS) and then this data was used to evaluate a kinetic model and calculate the constant kinetic reaction of the pyrolysis process. The results indicated that bio-oil production begins from 100 °C, however, temperatures between 200-250 °C favor the production of bio-oil, while temperatures above 250 °C and the long residence times prioritize the production of bio-gas. Regarding the kinetic evaluated, the reactions seem to show from third to sixth order with an activation energy (E) of around 30 kj/mol and a pre-exponential factor (ln A) of around 9 s-1. Based on GC-MS Analysis, the bio-oil contains short chain alkanes, cycloalkanes, organic acids as well as aromatic, phenol, benzene compounds. On the other hand, although small amounts of oil were achieved, the decomposition of biomass was up to 50% favoring gas production, these results indicate that MAP has potential in the obtaining of biofuels such as bio-gas and bio-oil.
Old Enemy with a New Face: Re-emerging Monkeypox Disease – An Update
Authors: Islam Md. Aminul , Hemo Mizbahul Karim , Chopra Hitesh , Amin Mohammad Ruhul , Bhattacharya Prosun , Dhama Kuldeep
Published: December 2022

Human monkeypox (MPX), a multi-country re-emerging disease, is rapidly spreading around the world. The etiological agent of this disease, Monkeypox virus (MPXV), is a DNA virus classified into three genetic types (West Africa, Congo Basin clade, and one new clade-3). Atypical or unusual symptoms as well as asymptomatic infection of MPXV has also been reported. Transmission among humans is possible by droplets, contact, sexual intercourse, and fomites. Secondary transmission of this disease has been reported to occur in less than 10% of cases where it was found 35%–88% of smallpox. Mother-to-fetus transmission by vertical route is also possible for this disease. Modern equipment, biosafety level-3 laboratory facilities, and trained expert persons are needed to diagnose this disease. Previous data support that ~85% clinical protection is provided by smallpox vaccines for monkeypox, although initially non-human primates models were used for various experiments, and also side-effects of this vaccine have been notably mentioned in various studies. Limited research findings of JYNNEOS vaccine has supported the comparatively lower prevalence of MPX cases with vaccination. Few drugs, including cidofovir, tecovirimat, brincidofovir, and vaccinia immune globulin intravenous are preferable against this disease, although clinical trial data is limited and FDA-approval is also pending. This review-based study presents an overall scenario of Monkeypox disease (MPXD) based on previously published studies. Recommended clinical treatment and vaccination, appropriate infection prevention and control strategies, adopting one health approach, and quick identification of hotspots using a wastewater-based surveillance system need to be followed to check the further spread of MPX outbreaks.
Monkeypox Viruses: Resurgence of Global Threat to Mankind
Authors: Manju K. , Ranjini H.K. , Raj S. Niranjan , Nayak S. Chandra , Chouhan Raghuraj Singh , Prasad Ashwini , Harini B.P. , Prasad M.N. Nagendra , Satish S. , Baker Syed
Published: December 2022

The unprecedented outbreaks of monkeypox viruses in non-endemic regions have created grave concern for global health. The World Health Organization has declared a public health emergency of international concern and stated the seriousness of monkeypox viruses. The gravity of this zoonotic disease cannot be underestimated, owing to the fact that this viral infection can cause pathetic situations if ignored. Keeping these lacunas, the scientific communities have expressed their interest towards the study of monkeypox viruses. Hence the present review discusses the etiological features, historical events, and vaccination along with management strategies to combat and counter the sudden outbreak. The review also highlights the current Indian scenario of the monkeypox virus; with scanty reports available, the present contributes towards the growing scientific knowledge to prevent a future threats to mankind.
An overview on Monkeypox, Current Paradigms and Advances in its Vaccination, Treatment and Clinical Management: Trends, Scope, Promise and Challenges
Authors: Sharma Varruchi , Aggarwal Diwakar , Sharma Anil Kumar , Chandran Deepak , Sharma Ajay , Chopra Hitesh , Emran Talha Bin , Dey Abhijit , Dhama Kuldeep
Published: December 2022

Monkeypox virus is an orthopoxvirus sharing the common genus with variola and vaccinia virus. Most of the monkeypox (MPX) cases had been reported from the central and west African region (the main endemic areas) prior to 2022 but there was a sudden outbreak in May, 2022 disseminating the infections to thousands of people even in non-endemic countries, posing a global public health emergency. MPX was considered a rae and neglected disease, however the 2022 MPX outbreaks in multiple countries attracted attention of worldwide researchers to pace up for carrying out researches on various aspects of MPXV including attempts to design and develop diagnostics, vaccines, drugs and therapeutics counteract MPX. Apart from being a zoonotic disease, the current outbreaks highlighted rapid human-to-human transmission of MPXV, besides the reverse zoonosis has also been documented with recent first report of human-to-dog transmission, urging a call for the importance of one health approach. Atypical and unusual disease manifestations as well asymptomatic MPXV infections have also been observed during 2022 MPX outbreak. The affected patients typically develop a rash resulting in a mild disease followed by recovery with some supportive care and use of antivirals such as tecovirimat, cidofovir and brincidofovir in severe disease cases. Modified vaccinia Ankara (MVA) vaccine with an excellent safety profile has been recommended to patients with higher risk exposure and immunocompromised individuals. Moreover, another vaccine the replication-competent vaccine (ACAM2000) could be a suitable alternative to MVA’s non-availability to some selective immunocompetent individuals. Current review highlights the salient aspects of management and treatment of monkeypox along with underlying promises in terms of therapeutics and a variety of challenges posed due to current global public health emergency situation to counteract MPX.
Candidate Vaccines and Therapeutics against Monkeypox Infection
Authors: Nainwal Nidhi , Jakhmola Vikash
Published: December 2022

While human beings are still facing the challenges of the pandemic coronavirus disease (COVID-19), a new viral disease, monkeypox raises concerns among healthcare authorities about this new threat. Since May 2022, thousands of people have been affected by a continuous monkeypox outbreak linked to close contact transmission in numbers of nonendemic nations. The Food and Drug Administration (FDA) has not yet approved any medications to treat monkeypox in humans. However, medications created for smallpox patients, such as antivirals and other medical countermeasures, might also be effective against monkeypox. Tecovirimat (TPOXX), brincidofovir, cidofovir antivirals and Vaccinia Immune Globulin Intravenous (VIGIV) are the medical countermeasures for the treatment of monkeypox. The second and third generations of smallpox vaccinations have been developed after many years of research. Some of these vaccines may also be beneficial for monkeypox. Three vaccinations, MVA-BN, LC16, or ACAM2000 can be used for monkeypox. Two of these (MVA-BN and LC16) have received approval for the purpose of preventing monkeypox. Considering the current vaccine shortage, widespread immunisation is not advised. Therefore, prevention is the best policy to keep everyone safe. The current review highlights the treatment available for the management of monkeypox. It also reviewed the preventive measures that human beings should take to protect themselves from monkeypox infection.
Discovering Extraordinary items from Binary Enhanced Database using APRIORI-BEAP Algorithm
Authors: Savitha R. , Deepa Dr. V. Baby
Published: December 2022

Abstract: An Item set is an instance format that is hidden beneath the raw data and after mining the database is created to help users make certain decisions to improve their business needs. Most of the previous studiesare carried out in extracting frequently occurring items or patterns and rare patterns are often ignored. Rare patterns are very useful in many areas like fraud detection, underselling products, intrusion attacks on networks, and these rare patterns indicate the user with some interesting detils to overcome and avoidthose problems. This paper proposes a new algorithm, BEAP algorithm, which uses binary representation and detects rare items without compromising speed and reduces memory consumption. From the experimental evaluation the proposed algorithm BEAP has been proved to be more effective and efficientthan the existing algorithms.
Advanced Intuitive Model for Digital Forensics Collection Methods in the Context of Cloud Computing and IoT
Authors: Kotasthane Abhijith , Khare Aparna , Sunil Bapat Gaurav , Kashikar Pradnya , Suhas S , Khullar Subin
Published: December 2022

Abstract: With the wide scale adoption of cloud computing paradigms and Internet of Things implementations, the arena of service delivery has changed significantly for the world of technology-oriented services. While these new modes of service delivery have provided innovations that were not fathomable earlier, they not only create new non-traditional pathways for evidence generation, nevertheless, they have also been seen to carry a potential of creating and exposing a whole new set of security vulnerabilities that malicious actors can exploit. Traditional forensic investigation process falls short in many ways including the way it aims to identify and link crucial pieces of evidence in these scenarios due to a myriad of internal and external factors. Challenges and inadequacies have been identified in the community in relation to these specific sets of advancing technologies that hinder the efficient identification, extraction and processing of evidence generated in crimes involving them. In this paper we wish to surmise the current forensic collection methods, how they pose challenges when put together with the latest cloud and IoT technologies and then attempt to propose an advanced, more intuitive, and theoretically validated digital forensic collection process guided by zero trust principle and enforced with artificial intelligence and machine learning methodologies with the aim to fill the gaps and provide a more reliable, robust and intuitive model to perform digital evidence collection in the given context.
Antibacterial effect of Caesalpenia bonducella Leaf Extract on Salmonella typhi
Authors: Kumar Rajesh
Published: December 2022

Abstract: Plants are important source of treatment for various diseases. We are using them from prehistoric times in our folk medicines. Many plants have their different medicinal properties, among them one is Caesalpinia bonducella. It has many local names in different languages, it is known as kantkaranja in Hindi and fever nut in English. It is prickly shrub widely distributed all over the world specially in tropical areas. All parts of plant have medicinal properties ,so it is utilized intraditional system of medicines. It is used for the treatment of several diseases. It is very popular in Ayurveda, Siddha, Unani and Homeopathic system of medicines. This review attempts to encompass the antityphoidal property of Caesalpinia bonducella.
Consumer Satisfaction of Chocolate Product and Its Marketing Facilities: Case Study of a MSME Chocolate Factory in Jember
Authors: Hartatri Diany Faila Sophia , Aprilia Sugesti Dwi
Published: December 2022

The role of micro, small and medium enterprises (MSME)-scale of cocoa agro-industry sector in Indonesia has increased along with the increasing number of MSMEs engaged in secondary cocoa processing sector. One of the factors that influence the sustainability of cocoa agroindustry business is customer satisfaction index (CSI). Therefore, this study aims to analyze consumer satisfaction index of chocolate product and its marketing facilities offered by producer which can then be used as input for the development of chocolate business. This research was conducted at MSME chocolate factory located in Jember, Indonesia. The selection of this location was done purposively with the consideration that the MSME chocolate factory produces couverture chocolate products. The research method chosen is descriptive using the analysis method of customer satisfactionindex (CSI) and importance performance analysis (IPA). There were 96 respondents involved in this research. Determination of sample size was calculated by using the Slovin formula. The results showed that the majority of the chocolate consumers are, young generation female who have well literacy of digital experiences. Furthermore, CSI of chocolate products and its marketing facilities was 77.86%, which indicates that overall consumers were satisfied. Several attributes that has satisfied the consumers are chocolate taste, packaging, chocolate shape, food safety guarantees labeled at the chocolate products, outlet cleanliness, outlet convenience, the atmosphere offered by the outlet, friendliness of the salesperson to the customer, salesperson’s knowledge of the menu, responsiveness of salespeople in fulfilling orders, attractive outlet interior design, cleanliness and availability of toilets, prayer rooms and supporting facilities for consumer comfort has also satisfied the consumers. Priority improvement strategies that require to be conducted to increase consumer satisfaction include adjusting the price of chocolate products, increasing promotions through social media and providing entertainment facilities, such as music, wi-fi, and TV at chocolate marketing facilities.
Проект «Мир Иммануила Канта» и современные возможности виртуальной реконструкции Кёнигсберга XVIII века: архитектурно-скульптурная декорация здания почты на рыночной площади Альтштадта
Authors: Белинцева Ирина , Баранова Елена , Верещагин Вячеслав , Маслов Виталий
Published: December 2022

В связи с приближающимся трёхсотлетием со дня рождения Иммануила Канта (1724-1804) в БФУ имени И. Канта в Калининграде в рамках стратегического проекта «Балтийская долина» создаётся уникальная виртуальная реконструкция нескольких улиц Кёнигсберга, по которым ходил немецкий философ. Сложность воспроизведения архитектурного окружения заключается в почти полном отсутствии сохранившихся элементов среды XVIII века и минимуме имеющихся изобразительных источников. Один из маршрутов пролегает от дома И. Канта до книжной лавки И.Я. Кантера (1738-178 6). На этом пути философ мог видеть здание почты на рыночной площади. Согласно проекту 1730 года, в центре фасада предполагалось сделать сложную архитектурно-скульптурную композицию со статуей короля Фридриха Вильгельма I (скульптор И.Х. Майсснер). После сноса здания в 1906-1907 годах декорация была перенесена на опорную стену перед южной стеной замка, дополнена фонтаном и рельефом (скульптор В. Розенберг). От памятника XVIII века в современном Калининграде сохранился небольшой фрагмент в виде полукруглой ниши, завершённой конхой и обрамлённой парными ионическими пилястрами, что позволило снять точные размеры и на основании со­хранившихся чертежей, рисунков и фотографий сделать виртуальную реконструкцию здания в 3D-модели с помощью современных компьютерных методик.
Будущие архитекторы-урбанисты С.А. Лопатин и В.С. Попов - авторы ключевых объектов в Самарканде. 1927 год
Authors: Верхотуров Филипп
Published: December 2022

Статья раскрывает новые подробности архи­тектурно-строительной практики будущих членов Объединения архитекторов-урбанистов (АРУ) В.С. Попова и С.А. Лопатина в период учёбы во ВХУТЕМАСе. На основе личных дел сту­дентов РГАЛИ и газетных публикаций впервые составлен перечень и дано описание реализованных ими проектов для Самарканда, сохранившихся до сегодняшнего дня. Освещают­ся обстоятельства, при которых студентам удалось совместить ответственную работу по реализации их проектов с учёбой во ВХУТЕМАСе. Опыт В.С. Попова и С.А. Лопатина явился важным этапом для предстоящих проектов АРУ в Средней Азии. Вы­явлено, что в основу построенного Терапевтического корпуса Республиканской больницы в Самарканде был положен со­вместный конкурсный проект архитекторов А.З. Гринберга и Н.В. Гофман-Пылаева.
И.В. Жолтовский - педагог УЖВЗ, вторых СГХМ, ВХУТЕМАСА. 1917-1923 годы
Authors: Иванова-Веэн Лариса , Печёнкин Илья , Шурыгина Ольга
Published: December 2022

В статье на основании архивных материалов (ГАРФ, РГАЛИ, ГНИМА им. А.В. Щусева и Музея МАРХИ), многие из которых впервые вводятся в научный оборот, освещена педагогическая деятельность крупного отечественного ар­хитектора Ивана Владиславовича Жолтовского (1867-1959) в первые революционные годы. В период конца 1917-го - 1923 годов он, почти не имевший ранее педагогического опыта, оказался чрезвычайно востребованным в роли преподава­теля архитектуры. Эта история особенно интересна потому, что Жолтовский был чужд новаторским экспериментам в архитектуре, придерживался консервативных взглядов и академического подхода к обучению профессии. Это не помешало ему снискать популярность среди учащихся москов­ского Училища живописи, ваяния и зодчества, затем - Вторых Свободных государственных художественных мастерских и, наконец, ВХУТЕМАСа. В последнем случае Жолтовский стал во главе партии традиционалистов, составлявших в начале 1920-х годов абсолютное большинство на архитектурном факультете. Это положение сохранялось вплоть до его отъезда в заграничную командировку осенью 1923 года.
Наука в пространстве Москвы: истоки развития
Authors: Бочаров Юрий , Фрезинская Наталия , Сергеев Кирилл
Published: December 2022

В статье рассматриваются проблемы возник­новения и пространственного развития московской науки на протяжении XVII века. Анализируются причины проведения научных исследований в царских приказах, аптеках, мона­стырских и светских школах, в первых высших учебных за­ведениях. Подчёркивается, что важным условием зарождения новой городской функции являлись успехи просвещения и появление в русской столице образованных людей. Большое внимание уделяется созданию Славяно-греко-латинской Академии и Школы математических и навигацких наук. Ха­рактеризуются принципы расселения учёных, в том числе приезжающих в Москву из других городов и стран, а также принципы расселения учащихся.

Рассматриваются факторы концентрации объектов науки в пределах территориального ареала «Кремль - Китай-город». Предметом анализа становится Никольская улица, выполняющая роль планировочной оси, ведущей от Кремля к северо-восточ­ной части города, и одновременно - «первого луча московской науки». Складывалась практика функционального зонирования пространства, в том числе, вертикального функционального зонирования. Отмечается, что во времена Петра I наука при­нимала участие в формировании архитектурных ансамблей, а объекты науки, возникающие в рамках многофункциональных градостроительных комплексов, проявляли способность доми­нировать в застройке городских площадей и районов. Приёмы пространственной организации исследовательской деятельно­сти, разработанные в XVII веке, сопоставляются с теми, которые используются архитекторами и градостроителями современной Москвы.
DAMPAK KEBERADAAN BUDI DAYA KERAMBA IKAN AIR TAWAR TERHADAP KESEJAHTERAAN MASYARAKAT DESA TOWEREN KECAMATAN LUT TAWAR KABUPATEN ACEH TENGAH
Authors: Furqan Furqan , Maghfirah Fitria Rizki
Published: December 2022

Abstract: A prosperous society is a society that has a good and sufficient economy so that it can provide a decent enough life. To meet the necessities of life and also a decent life, of course the community must try, as the people of Toweren Village who started fish cage cultivation in order to achieve a prosperous family. The research problem is formulated into two: First, what is the impact of freshwater fish cage cultivation on the welfare of the people of Toweren Village. Second, what is the response of the Toweren Village Community regarding the Existence of Freshwater Fish Cage Cultivation. The purpose of this study was to determine the impact of fish cage cultivation and the public's response to fish cage cultivation. This research is a field research using a qualitative descriptive approach. Data collection techniques by way of observation and interviews. The results of the study show that fish cage cultivation can improve the economy and can meet the needs of the community and can reduce the unemployment rate of the people of Toweren Village so that the people of Toweren Village can be said to be a prosperous society. In addition, fish cage cultivation has a negative impact, namely, environmental pollution and becomes an obstacle to community activities such as fishermen and anglers.Keywords: Aquaculture; Fish Cage; Welfare; Community.   Abstrak: Masyarakat yang sejahtera merupakan masyarakat yang memiliki ekonomi bagus dan mencukupi sehingga dapat memberikan kehidupan yang cukup layak. Untuk memenuhi kebutuhan hidup dan juga kehidupan yang layak tentunya masyarakat harus berusaha, sebagaimana masyarakat Desa Toweren yang memulai budi daya keramba ikan agar mencapai keluarga yang sejahtera. Masalah penelitian dirumuskan menjadi dua: Pertama, Bagaimana dampak usaha budi daya keramba ikan air tawar terhadap kesejahteraan masyarakat Desa Toweren. Kedua, Bagaimana tanggapan Masyarakat Desa Toweren mengenai Keberadaan Budi Daya Keramba Ikan air tawar. Tujuan penelitian ini untuk mengetahui dampak budi daya keramba ikan dan tanggapan masyarakat terhadap budi daya keramba ikan. Penelitian ini merupakan penelitian lapangan melalui pendekatan Deskriptif kualitatatif. Teknik pengumpulan data dengan cara observasi dan wawancara. Hasil penelitian menunjukkan bahwa budi daya keramba ikan dapat meningkatkan ekonomi dan dapat memenuhi kebutuhan hidup masyarakat serta dapat mengurangi tingkat pengangguran masyarakat Desa Toweren sehingga masyarakat Desa Toweren dapat dikatakan ke dalam masyarakat yang sejahtera. Selain itu budi daya keramba ikan memiliki dampak negatif yaitu, pencemaran lingkungan serta menjadi penghambat aktivitas masyarakat seperti nelayan dan pemancing.Kata Kunci: Budi Daya; Keramba Ikan; Kesejahteraan; Masyarakat.
Tantangan Radikalisme dan Upaya Deradikalisasi Beragama
Authors: Devi Sunita , Arif Mahmud
Published: December 2022

Radicalism is a delicate subject with the potential to disrupt the natural order. This study aims to determine the meaning of radicalism, the genealogy of religious radicalism, the factors that cause radical Islam, and deradicalization efforts. This research was a qualitative method with descriptive approach. Based on the research results, it is known that radicalism's teachings and movements are a movement that leads to ideological changes both politically and socially through violence, which is contrary to Islamic values. The challenge of radicalism is overcome by various deradicalization efforts so that it can maintain the nature of Islam itself. Deradicalization is not intended as an attempt to convey a "new understanding" of Islam or to refute the creed but rather as an effort to purify the understanding of what and how Islam is.Abstrak      Radikalisme merupakan suatu pembahasan yang sangat sensitif dan merupakan paham yang dapat menggoyahkan tatanan kehidupan. Penelitian ini bertujuan untuk mengetahui makna dari radikalisme, genealogi radikalisme agama, faktor terjadinya Islam radikal, serta upaya deradikalisasi. Penelitian ini menggunakan metode kualitatif dengan pendekatan deskriptif. Berdasarkan hasil penelitian diketahui bahwa ajaran dan gerakan radikalisme merupakan suatu pergerakan yang menuju kepada perubahan ideologi baik secara politik maupun sosial melalui jalan kekerasan, dan ini bertentangan dengan nilai-nilai keislaman. Tantangan radikalisme diatasi dengan berbagai upaya deradikalisasi sehingga dapat menjaga fitrah dari agama Islam itu sendiri. Deradikalisasi bukan dimaksudkan sebagai upaya untuk menyampaikan “pemahaman baru” tentang Islam dan bukan pula pendangkalan akidah, melainkan sebagai upaya purifikasi atau pemurnian pemahaman tentang apa dan bagaimana Islam.
The effect of CRP/albumin ratio on prognosis of hospitalized patients due to COVID-19
Authors: ŞEN Nesrin , TEZCAN Mehmet , DOGAN GOKCE Gizem , ZORLUTUNA KAYMAK Nilüfer , ACER Sevtap , ALGA BATIREL Ayşe
Published: December 2022

Introduction: COVID-19 disease caused by the SARS-Cov-2 virus is characterized by clinical spectra of varying severity. Coagulopathy and inflammation are the most important factors associated with COVID-19 severity. The use of a biomarker of inflammation and coagulation factors has not yet been clarified. The present study aimed to examine the role of CRP/Albumin, an inflammation marker, in predicting the course of COVID-19 disease.Methods: The Demographic, laboratory, and prognosis of 457 patients who were hospitalized during the COVID-19 pandemic service between April and May 2020 were analyzed retrospectively. The relationship between the patients' CRP/Albumin ratio and disease severity, length of hospital stays, and prognosis were analyzed.Results: The rate of hospitalization in the intensive care unit was 10.5% (n=48), mechanical ventilation was 8.1% (n=37), and death was 1.3% (n=6). The CRP/albumin ratio was statistically higher in those with lung infiltration (p=0.005), those who were taken to the intensive care unit (p<0.001), and those who needed mechanical ventilation (p<0.001). A positive significant correlation was found between the length of hospital stay and the CRP/albumin ratio(r=0.412, p < 0.001).Conclusion: The CRP/Albumin ratio is thought to be an auxiliary marker for doctors in the early transfer of patients to the intensive care unit, the early detection of those in need of MV, and the determination of lung infiltration.Keywords: COVID-19, CRP/albumin ratio, prognosis
Peculiarities of allocating public finances for special territories (as exemplified by the Donetsk People’s Republic)
Authors:   Donetsk National University of Economics and Trade named after Mikhail Tugan-Baranovsky, Gradinarova Arina
Published: December 2022

Introduction. The relevance of the research topic is determined by the necessity to study financial phenomena and processes in order to understand the economic essence of public finance in the life of society. The strategic imperative for the formation of public finance is the development of an appropriate provision for its implementation, adequate to the complex and changeable circumstances of the territory development. The main purpose of the study is to identify the features of performing the functions of public finance for regions with a specific mode of operating. Methods. When solving the tasks, the author uses general logical methods: analysis, synthesis, induction, deduction, analogy; empirical level methods: observation, description, measurement, modeling, as well as private and special methods of scientific research: comparative analysis, system approach, the Robinsonade model (Crusoe model). Scientific novelty of the research. The scientific novelty of the results lies in solving an important scientific problem - identifying the features of implementing the allocative function of public finance in the regions with a specific mode of operating (as exemplified by the Donetsk People’s Republic, where there is a special military and political situation, a mobilization type of economy, a transitional period due to the integration of the Republic into the system of the Russian Federation federal relations) in order to improve the system of public finance management in such regions. Results. The main results of the study consist in characterizing the process of implementing the allocation function of public finance, which makes it possible to determine the maximum effect of economic actions of the subjects in the current conditions, as well as to lay the foundations for analyzing the following distribution function of public finance. Conclusions. The author makes a conclusion that in the context of strengthening the role of public finance, not only in ensuring the economic development of the Donetsk People’s Republic, but also in the post-crisis recovery and stabilization of business activity, the implementation of the allocation function of public finance becomes important.
Prevalensi diare pada santri pondok pesantren di Kota Medan
Authors: Purnama Tri Bayu , Tanjung Riyan Rahmat R , Siregar Waridah Santi
Published: December 2022

Pondok pesantren merupakan ranah pembelajaran, pengembangan karakter dan pendidikan agama islam dengan meninjau berbagai aspek termasuk aspek kesehatan. Pesantren menjadi tempat berkumpulnya siswa dari berbagai kelompok usia dan latar belakang sosial ekonomi yang berbeda beda sehingga berada pada kondisi rawan terhadap berbagai permasalahan kesehatan terutama Diare. Penelitian ini bertujuan untuk mengetahui prevalensi diare pada santri pondok pesantren di Kota Medan. Penelitian ini menggunakan desain cross-sectional dengan simple random sampling secara acak sederhana. Populasi penelitian ini adalah seluruh santri yang tersebar di Kota Medan, Provinsi Sumatera Utara dengan sampel sebanyak 436 santri yang berasal dari 7 pesantren di Kota Medan. Instrumen pengumpulan data berupa selfreport questionnaire dengan uji Uji chi square. Penelitian ini menemukan bahwa prevalensi diare pada santri di Kota Medan sebesar 48,6% dan bervariasi antar pesantren (20-80%). Berdasarkan hasil uji statistic diketahui bahwa Jenis kelamin memiliki perbedaan yang signifikan (p-value 0,000 < 0,005) dengan Prevalens Risk (PR) pada 95% CI 1,995 (1,362 – 2,922) yang menunjukkan bahwa laki-laki berisiko 2 kali lebih besar terinfeksi diare dibandingkan perempuan, Proporsi santri yang diare dan tidak rutin cuci tangan pakai sabun lebih besar dibandingkan yang diare dan rutin cuci tangan pakai sabun. Edukasi secara menyeluruh terutama pada kelompok laki-laki menjadi rekomendasi dalam memutuskan rantai penularan diare di pesantren.
Survei nyamuk Culex sp. pada lingkungan sekitar penderita filariasis di Kabupaten Brebes
Authors: Magfiroh Ulfatul , Siwiendrayanti Arum
Published: December 2022

Jumlah kasus filariasis di Kabupaten Brebes meningkat dari tahun ke tahun. Penderita filariasis pada tahun 2016, 2017, dan 2018 berturut-turut terdapat 25, 54, dan 61 kasus filariasis di Kabupaten Brebes. Pada tahun 2018 Kabupaten Brebes menempati urutan kedua kasus filariasis terbanyak di Provinsi Jawa Tengah. Tujuan penelitian untuk mengetahui gambaran kondisi lingkungan sekitar penderita, kepadatan nyamuk, angka dominasi, dan angka infeksi mikrofilaria nyamuk Culex sp. Jenis penelitian yang digunakan adalah deskriptif kuantitatif. Teknik pengambilan sampel menggunakan metode total sampling. Analisis data dalam penelitian ini menggunakan analisis univariat. Lingkungan fisik yang berisiko adalah genangan air, selokan, kandang ternak, dan semak-semak. Kepadatan nyamuk di tempat penelitian yang belum memenuhi persyaratan Permenkes No. 50 Tahun 2017 adalah Kecamatan Ketanggungan (Desa Ketanggungan, Dukuhturi, Karangmalang, Baros, Cikeusal Lor, dan Jemasih) serta Kecamatan Paguyangan (Desa Taraban). Nyamuk yang paling dominan adalah nyamuk Culex quinquefasciatus dengan angka dominasi sebesar 85,25%. Berdasarkan hasil pembedahan semua spesies nyamuk tidak mengandung mikrofilaria. Kami menyarankan dinas kesehatan setempat untuk melakukan pengelolaan lingkungan dan tindakan preventif untuk mencegah penularan filariasis.
Hubungan ko-infeksi soil-transmitted helminths terhadap status gizi pada penderita tuberkulosis di Kecamatan Puger
Authors: Suswati Enny , Taryafi Muhammad Alif , Hermansyah Bagus , Shodikin Muhammad Ali , Armiyanti Yunita , Raharjo Angga Mardro
Published: December 2022

Tuberkulosis (TB) adalah penyakit yang disebabkan oleh infeksi Mycobacterium tuberculosis. Kejadian ko-infeksi parasit di daerah endemik TB sering dilaporkan yang mengakibatkan kondisi penderita TB semakin parah dan sulit disembuhkan. Ko-infeksi cacing pada penderita TB diketahui berpengaruh terhadap respon imun, proses pengobatan, status gizi, dan prognosisnya.  Tujuan penelitian ini adalah untuk mengetahui hubungan ko-infeksi soil-transmitted helminthiasis (STH) terhadap status gizi pada penderita TB di Kecamatan Puger, Kabupaten Jember. Studi ini adalah penelitian observasi dengan desain cross sectional yang dilakukan di Puskesmas Puger, Kabupaten Jember, Jawa Timur pada September 2019 sampai Januari 2020. Data ko-infeksi cacing pada penderita TB diperoleh dari pemeriksaan feses dengan metode sedimentasi dan flotasi sedangkan status gizi diperoleh dari pengukuran indek masa tubuh (IMT). Analisis data menggunakan uji Chi-square untuk mengethui adanya hubungan ko-infeksi STH terhadap status gizi penderita TB. Hasil penelitian menunjukkan bahwa 6 dari 32 pasien TB (18,72 %) terinfeksi STH, 4 (%) terinfeksi Ascaris lumbricoides, dan 2 (%) terinfeksi hookworms. Hasil pengukuran IMT adalah18 (56,25%) yang mengindikasikan bahwa penderita TB berstatus gizi kurang dan14 (43,75%) berstatus gizi normal. Hasil uji Chi Square menunjukkan tidak   ada hubungan ko-infeksi STH terhadap status gizi penderita TB (p>0,05). Dengan demikian, perlu dilakukan edukasi pada penderita TB tentang gizi seimbang khususnya di wilayah puskesmas Puger Kabupaten Jember, Jawa Timur agar status gizi dapat meningkat.
Hubungan Penerapan Etika Batuk pada Penderita TB Paru dengan Kejadian TB Paru pada Pasangan di Kecamatan Darul Imarah Kabupaten Aceh Besar
Authors: Hermaya Putri , Safarianti Safarianti , Mamfaluti Teuku
Published: December 2022

Tuberkulosis (TB) Paru merupakan salah satu penyakit infeksi penyebab kematian tertinggi di dunia. Lingkungan yang memiliki risiko penularan Mikobakterium tuberkulosis (MTB) yang besar adalah rumah. Pasangan merupakan anggota yang memiliki lama dan kualitas kontak terbaik di rumah. WHO merekomendasikan 7 poin rekomendasi untuk mencegah transmisi MTB, salah satunya adalah penerapan etika batuk. Penelitian ini bertujuan untuk mengetahui hubungan penerapan etika batuk pada penderita TB Paru dengan kejadian TB Paru pada pasangan penderita di Kecamatan Darul Imarah Kabupaten Aceh Besar. Penelitian ini merupakan penelitian analitik observasional dengan desain cross-sectional. Data diolah menggunakan uji chi square terhadap 94 sample yang diambil dengan simple random sampling. Hasil penelitian didapatkan 76,6% dari penderita TB Paru tidak menerapkan etika batuk dengan baik dan hanya 3,2% pasangan penderita yang mengalami TB Paru. Penelitian ini menunjukkan bahwa penerapan etika batuk yang buruk pada penderita TB Paru tidak berpengaruh secara signifikan terhadap kejadian TB Paru pada pasangan (p=0,072). Hal ini disebabkan sedikitnya jumlah pasangan yang terkena TB Paru. Faktor lingkungan dalam pengendalian MTB dan peran genetik dalam kerentanan terhadap MTB diduga berperan dalam kejadian ini.
Editorial
Authors: Raffnsøe et al. Sverre
Published: December 2022

Sverre Raffnsøe, Alain Beaulieu, Barbara Cruikshank, Bregham Dalgliesh, Knut Ove Eliassen, Verena Erlenbusch, Alex Feldman, Marius Gudmand-Høyer, Thomas Götselius, Robert Harvey, Robin Holt, Leonard Richard Lawlor, Daniele Lorenzini, Edward McGushin, Hernan Camilo Pulido Martinez, Giovanni Mascaretti, Johanna Oksala, Clare O’Farrell, Rodrigo Castro Orellana, Eva Bendix Petersen, Alan Rosenberg, Annika Skoglund, Dianna Taylor, Martina Tazzioli, Andreas Dahl Jakobsen & Rachel Raffnsøe.
Cultura democrática em meio à pandemia de coronavírus no Brasil:
Authors: Moraes Diego , Moisés José Álvaro
Published: December 2022

Este artigo parte dos dados do projeto Valores em Crise para discutir em que medida a cultura democrática foi afetada pela pandemia de covid-19 no Brasil. Tal projeto se valeu de uma abordagem de painéis longitudinais para avaliar os valores e atitudes sociopolíticas de uma amostra nacional de brasileiros em três momentos distintos da pandemia. Os resultados mostram uma ampla estabilidade na maioria das variáveis de cultura democrática ao longo da pandemia, sugerindo que a crise do coronavírus não afetou significativamente a cultura política dos brasileiros. Todavia, identificamos importantes variações no nível das desagregações sociodemográficas que merecem consideração. Concluímos que, embora em um primeiro momento a crise sanitária tenha fomentado algumas forças de capital social e de apoio às instituições, o contexto político altamente conturbado limitou qualquer oportunidade de se valer dessa situação para avançar nossa democracia.
Palavras-chave: Cultura Democrática. Valores em Crise. Democracia. Painel Longitudinal. Covid-19.
Violência civilizatória e neoliberalismo:
Authors: Guerreiro Clayton , Milisse Chambe Zacarias , De Regina Cassalho João
Published: December 2022

Este artigo estabelece um paralelo analítico entre duas situações etnográficas distintas em Moçambique: a “Operação Limpeza”, uma campanha de repatriamento por forças da polícia da República de Moçambique iniciada em Montepuez em 2019, cuja nomenclatura reactivou práticas e discursos de uma acção iniciada em 1974, durante o governo de transição de Moçambique, e o discurso civilizatório, por meio do empreendedorismo, em igrejas pentecostais em Maputo. Embora díspares, as duas situações são fenómenos sociopolíticos relativas ao avanço do neoliberalismo no país. O argumento é de que ambas se relacionam com uma violência moral que orienta processos modernizantes, civilizadores e de empreendedorismo, os quais pressupõem que os moçambicanos precisariam ser educados pelo trabalho. Esses processos, alinhados ao neoliberalismo, pretendem a transformação moral dos moçambicanos, estabelecendo continuidades com fenómenos e discursos de outros momentos históricos do país.    
Palavras-chave: Neoliberalismo. Deslocamento. Política. Religião. Civilização.
O que ensinar na Ginástica Rítmica?
Authors: De Oliveira Laura , Nunomura Myrian
Published: December 2022

O objetivo deste estudo foi identificar e analisar o conteúdo desenvolvido na iniciação esportiva competitiva da Ginástica Rítmica (GR). Entrevistamos seis treinadoras das categorias de base de instituições medalhistas em ao menos uma categoria dos Campeonatos Brasileiros de GR 2019. Por meio da análise temática, cinco temas emergiram: (1) Especializar versus Ampliar: fatores que limitam e contribuem para o desenvolvimento físico-motor na iniciação esportiva da GR; (2) O posicionamento corporal é “regra” na GR; (3) Dificuldades corporais: treinar para aprender ou treinar para competir?; (4) De elemento acessório a elemento essencial: a valorização dos aparelhos da GR; (5) Dentro das regras e fora dos treinos: O componente artístico na GR. Sugerimos que o conteúdo preze pelas características, saúde, formação em longo prazo e desenvolvimento integral das ginastas. Por tratar-se de crianças, os resultados não seriam prioritários nessa fase e o conteúdo deveria apoiar-se na visão de futuro da modalidade.
Solidariedade em ação
Authors: Luguetti Carla , Gonçalves Luiza Lana , Borges Cecilia , MacPhail Ann
Published: December 2022

O objetivo deste artigo é oferecer um modelo para colegas que desejam aproveitar a oportunidade de trabalhar juntos em todas as nacionalidades para questionar a solidariedade. Nesta seção Em Foco, vinte e dois pesquisadores (nove brasileiros e treze internacionais) trabalharam em seis pequenos grupos durante dois anos para escrever sobre suas experiências com práticas colaborativas. Partindo do conceito de solidariedade de Freire, os editores compartilharam as etapas do processo de co-design, bem como suas visões que resultaram em três temas: (a) a necessidade de aumentar a visibilidade da comunidade acadêmica brasileira; (b) nosso cuidado coletivo com linguagem e comunicação; e (c) como ao liderar este projeto nos repensamos de diferentes maneiras. Defendemos que o modelo da seção Em Foco coelaborada deve ser fundamentado na solidariedade quando utilizado por colegas de outros países. É uma solidariedade baseada na partilha da luta para mudar as desigualdades sociais com as pessoas e a vontade de doar e repensar a nós mesmos.
Application of Profile Prediction for Proactive Scheduling
Authors: Dos Santos Allan Matheus Marques , Pinto Raquel Coelho Gomes , Duarte Julio Cesar , Schulze Bruno Richard
Published: December 2022

Today, cloud environments are widely used as execution platforms for most applications. In these environments, virtualized applications often share computing resources. Although this increases hardware utilization, resources competition can cause performance degradation, and knowing which applications can run on the same host without causing too much interference is key to a better scheduling and performance. Therefore, it is important to predict the resource consumption profile of applications in their subsequent iterations. This work evaluates the use of machine learning techniques to predict the increase or decrease in computational resources consumption. The prediction models are evaluated through experiments using real and benchmark applications. Finally, we conclude that some models offer significantly better performance when compared to the current trend of resource usage. These models averaged up to 94% on the F1 metric for this task.
GÊNESE DO ESPAÇO URBANO COMO ABISMO EM DUAS NARRATIVAS DE CONCEIÇÃO EVARISTO
Authors: Conceição Francis Willams Brito da , Cordiviola Alfredo Adolfo
Published: December 2022

Neste artigo, focaremos nos deslocamentos e nas percepções do espaço criados através do movimento de corpos que transitam pelos entre-lugares, marcando um (não) pertencimento, temática recorrente nos textos literários produzidos por mulheres negras. Considerando que algumas teóricas dos estudos sobre o espaço, como Massey (2008, p. 69), podem dialogar com o conceito de “erosão do espaço heterogêneo”, de Foucault (2013, s/p), ao ressaltar a afetação espacial que os corpos, socialmente marginalizados, sofrem nos contextos globais de poder (BHABHA, 1998, p. 292), investigaremos a representação de dois espaços nomeados, respectivamente, Buracão e Grota, presentes no romance “Becos da Memória” (2017) e no conto “Grota Funda” (2017), de Conceição Evaristo. Para tanto, nos basearemos nas discussões de Conceição Evaristo (2005), Nazareth Fonseca (2017), Simone Schmidt (2016), entre outros. Ademais, a hipótese que norteará este estudo é que, a representação do abismo no conto, tem sua gênese no romance, no Buracão da favela.
CINCO CONTEMPORÂNEAS ANGLÓFONAS DE CAROLINA MARIA DE JESUS
Authors: Alexander Ian
Published: December 2022

Roberta Flores Pedroso descreve Carolina Maria de Jesus (1914-1977), autora de Quarto de despejo (1960), como “mulher negra, pobre, semialfabetizada e migrante” que “se tornou um fenômeno editorial”. Na tentativa de estabelecer um contexto anglófono para a leitura comparativa de Quarto de despejo, este artigo apresenta cinco autoras negras, anglófonas, de países periféricos, nascidas entre 1904 e 1924, e analisa de quais maneiras os termos pobre, semialfabetizada, migrante e fenômeno editorial devem ser relativizados para poder fazer a comparação. As autoras são Oodgeroo Noonuccal (1920-1993) e Faith Bandler (1918-2015), da Austrália; Ellen Kuzwayo (1914-2006), da África do Sul, e Una Marson (1905-1965) e Louise Bennett (1919-2006), da Jamaica.
RESPOSTA DOS PARÂMETROS DO ANDAR APÓS INTERVENÇÃO COM DICAS AUDITIVAS RÍTMICAS EM IDOSOS COM DOENÇA DE PARKINSON
Authors: Silva Tamires Vicente , Orcioli Silva Diego , Spiandor Beretta Victor , Teresa Bucken Gobbi Lilian , Vitorio Rodrigo
Published: December 2022

Introdução: os comprometimentos do andar em idosos com doença de Parkinson (DP) estão associados à elevada ocorrência de quedas e à redução dos níveis de independência. O objetivo do estudo foi comparar a resposta dos parâmetros do andar em idosos com doença de Parkinson (DP), durante, imediatamente após e até uma hora após o término de uma sessão de treinamento do andar com e sem dicas auditivas rítmicas, utilizando três ritmos diferentes para o grupo dica (10% abaixo da cadência preferida, cadência preferida e 10% acima) e um ritmo diferente para o grupo controle (velocidade usual de cada participante). Métodos: vinte e nove idosos foram aleatoriamente distribuídos em dois grupos: “controle” e “dica”. As sessões de intervenção tiveram 30 minutos de duração e a diferença entre os grupos foi a utilização de dicas auditivas rítmicas oferecidas por um metrônomo no grupo dica. O andar foi avaliado antes, durante e até uma hora após a sessão de intervenção. Resultados: os grupos apresentaram desempenhos similares ao longo das avaliações, com aumento do comprimento do passo e redução da variabilidade daduração do passo. Conclusão: a sessão de intervenção com dicas auditivas rítmicas apresentou efeitos similares aos da sessão de treino sem dica para o andar de idosos com DP.