bluuebunny/crossref_metadata_2025 huggingface dataset:
Desain Indutri Sebagai Karya Yang Dilindungi (HAKI)
Authors: Azhari AR Azhari AR
Published: April 2021

A designer has a copyright on the results of his creativity in the form of a blueprint and has the exclusive right to make the artwork into three or two dimensions. The industrial design law is directed at protecting mass-produced goods. People prefer protection with the right to industrial design, which is only protected for 10 years. This is because a design is very easy and can be imitated quickly by the general public. When it is protected by copyright, it becomes ineffective and wasteful. Copyright does not protect mass products.Keywords: Design, Industry, Work, Intellectual Property Rights
Peran Penyidik Polri Dalam Pencegahan Dan Penegakan Hukum Tindak Pidana Korupsi
Authors: Susilawati Susilawati
Published: April 2021

Corruption is very detrimental to the country's finances and impedes national development. Corruption that has occured so far has also resulted in inhibiting the growth and continuity of national development which demands high efficiency. In this case, those who play a role in the prevention and  enforcement of criminal acts of corruption, are not only the prosecutor and the court but also the National Police regulated in Law No. 2 of 2002 concerning the  Indonesian National Police. The situation above aroused the problem that is, what are the duties and functions of investigators of the Directorate of Special Criminal Investigation of the North Sumatra Regional Police in the prevention and enforcement of criminal acts of corruption, what is the role of investigators of the Directorate of Special Criminal Investigation of the North Sumatra Regional Police in the prevention and enforcement of criminal acts of corruption, what are the obstacles faced by investigators of the Directorate of Special Criminal Investigation of the North Sumatra Regional Police in the prevention and enforcement of criminal acts of corruption.Based on the results of the study, the duties and functions of the police investigator of the Directorate of Special Criminal Investigation of the North Sumatra Regional Police in the prevention and law enforcement of criminal acts of corruption, namely the existence of prevention, detection and correction regulated in Law No. 2 of 2002 concerning the North Sumatra Regional Police. The role of investigators of the Special Criminal Investigation Directorate of the North Sumatra Regional Police in the prevention and enforcement of criminal acts of corruption is to carry out stages such as inquiry and
Kepastian Dan Perlindungan Hukum Terhadap Pemegang Sertifikat Hak Milik Atas Tanah Berdasarkan Undang-Undang No.5 Tahun 1960 Tentang Peraturan Pokok-Pokok Agraria
Authors: Butarbutar Jawakil
Published: April 2021

This research is related to the Basic Agrarian Law which regulates land rights including property rights by registering the rights to their land to obtain ownership rights intended for maintain legal certainty and legal protection for holders of property rights over land. For this reason, it is important to socialize the importance of registering uncertified land to become certified land for legal certainty and protection of holders of property rights on the land to avoid land problems in the community. For this reason legal certainty and protection are needed so that the status of land owned by the people is clear as well as all actions taken relating to the land such as transfer, inheritance, transfer of rights, revocation / exemption and abolition of the land rights. With the certificate, the government has a definite role to provide legal protection to the  holders of property rights because the certified land has been registered at the landoffice and it becomes an obligation for the government to protect it. Keywords: Legal Certainty and Protection, Holders of Certificates of Ownership,  Agrarian Basic Law.
Analisis Atas Keabsahan Perkawinan Beda Agama
Authors: Nasution Hamdan
Published: April 2021

Marital status of different religions in the legal system in Indonesia is illegitimate. Marriage Law Number 1 of 1974 in Article 2 paragraph 1 reveals that marriage is legal if it is carried out according to the law of each religion and belief. It means that marriage can only take place if the parties (future husband and wife) follow the same religion. From the formulation of Article 2 paragraph 1, there are no marriages outside their respective laws and beliefs. Interfaith marriages are held abroad. Keywords: Analysis, Legitimacy, Interfaith Marriage
Perbuatan Melawan Hukum Menguasai Tanah Hak Milik Orang Lain (Studi Putusan Mahkamah Agung Nomor 3302 K/Pdt/2018)
Authors: Rahendra Lubis M. Faisal
Published: April 2021

Unlawful deed are an adverse effect to the rights of other people created by the law. This indicates that unlawful deed of disobedience based on consent and legal actions resulting from man’s own actions. Studies suggest that an act is unlawful when it adds to the several elements of an act, it must unlawful deed, it must inflict harm, it is wrong, and between the act and the harm inflicted there must be a causal relationship. Unlawful deed in this case by violating the ordinance in article 1335 dan article 1337 KUHPerdata, that is a forbidden cause and the existence of covenant matters or materials in violation of the law make it subject to article 1365 KUHPerdata. It was concluded that elements of unlawful deed constituted unlawful deed performed by the individual and those works were contrary to the right of another person to possession of property that didn’t belong to him. As a result when a man takes possession of the land of another’s property, the owner of the land of another’s property is required to vacate and return the land of property rights to its owner. All forms of deeds are categorized unlawful deed when they are unlawful deed, and when an individual has done wrong at the expense of the rights of another.Keywords: Unlawful Deeds, Legal Consequences, Land Of Proferty
Bunga Bank Konvensional Dan Pasar Modal Syariah Dalam Perspektif Hukum Islam
Authors: Supaino Supaino
Published: April 2021

This paper aims to examine the problems of conventional bank interest and the Islamic capital market in the perspective of Islamic law. The debate regarding the concept of interest and usury against additional rewards (benefits) from conventional banking products and the Islamic capital market has become a polemic in the life of Indonesian Muslim communities. The opinion of the scholars in addressing interest in the context of conventional banking and usury has generated its own debate, as well as the capital market in the perspective of sharia. This research is a literature research using both classical and contemporary fiqh books, holy books and journals regarding conventional bank interest and Islamic capital markets which are analyzed descriptively. In conclusion, conventional bank interest is a part of a form of usury which is prohibited, although there are differences of opinion among scholars in it. Likewise, the capital market, while it related to the Islamic capital market, there are various opinions of Islamic law scholars and it has given birth to the decision of Majma 'Fiqh. Keywords: Conventional Bank, Sharia Capital Market, Islamic Law
Penegakan Hukum Abstract Terhadap Pelaku Tindak Pidana Kekerasan Dalam Rumah Tangga (Studi Penelitian Pada Polrestabes Medan)
Authors: Syarifuddin Syarifuddin
Published: April 2021

The purpose of law enforcement is to harmonize the relationship of the values that are outlined in the rules, and to create, maintain and preserve peace in social life. Women and children are very vulnerable to becoming victims in all forms of violence or criminal acts, including violence in the domestic sphere. This research is descriptive analysis because it only explains about legal arrangements, law enforcement, as well as barriers and efforts to enforce the law by Medan Police against perpetrators of criminal acts of domestic violence (Research Study at Medan Police).The regulation of domestic violence law is contained in the Article 4 of Law of the Republic of Indonesia Number 23 of 2004 concerning Domestic Violence which states that the purpose of domestic violence is to prevent all forms of domestic violence, protect victims, take action against perpetrators, and maintain the integrity of the household. The application of the law by the police against the perpetrators of criminal acts of domestic violence prioritizes prevention, protection of victims, and maintaining household integrity. Barriers and efforts in law enforcement are that the regulations contained in PKDRT Law have not been integrated with other statutory regulations for law enforcement against criminal acts of domestic violence, so that the police strive to deal with restorative justice in order to improve and maintain the integrity of the households of the people dealing with the law.Keywords: Law Enforcement, Perpetrator, Criminal Acts, Domestic Violence
Community acquired pneumonia. Differential diagnosis. COVID-19
Authors:   Odessa National Medical University, Ukraine, Sokolov V. N. , Anischenko L. V. ,   Odessa National Medical University, Ukraine, Byanov A. S. ,   Odessa National Medical University, Ukraine, Nikitina O. V. ,   Odessa National Medical University, Ukraine
Published: April 2021

Introduction. The paper presents the results of X-ray examination of patients with lung lesions caused by diseases and computed tomography (CT) of patients with COVID-19 of varying degrees of infiltration according to the categorical CT scheme from CO-RADS 1 to CO-RADS 6, developed by the Dutch Radiological Society (NVvR). Good results can be achieved by detecting the early stage of the disease in COVID-19. The work considers indications, contraindications, methodology and interpretation, at different phases of infil-tration in COVID-19. Objective. To review the dynamic models of CT imaging of lungs affected by COVID-19, to define CT character of primary and post-primary infection and discuss the role of imaging in differential diagnostics and monitoring of the pathology. Materials and research methods. 85 patients (the median of 48 y.o. to the 17 to 84 y.o. range) were examined. All patients un-derwent CT procedure («Toshiba Corp.» 64-sl. CT). Results. At an early stage bilateral basal peripheral changes of the «ground glass» type opacity, generally of minuscule area, pre-dominate which precurse development of viral pneumonia in COVID-19. As the disease progresses areas of change in the tissue appear patterned according to the type of «patchwork», consolidation areas form resembling OP «reverse halo». Complete resorption of changes in lungs is likely. Resolution of pathological changes could be observed after a month and longer with a successful outcome. Conclusion. At the stage of the outbreak progression the role of CT imaging methods in assessing the condition of lungs could not be overestimated. They provide means to identify changes at the subclinical stage, to assess the severity of the course and conduct differential diagnostics, but also to inform about the likelihood of COVID-19 when PCR testing results are lacking. The role of CT is in-deed prevailing in clinical conditions of limited resources and while coping with a large patient cohort with acute respiratory diseases of undefined aetiology. Key words: Differential diagnosis; CT examination; COVID-19; CO-RADS scheme.
Bioinformational significance of the past–present–future for integral assessment of the functional state of the human organism
Authors:   State Institution «Y.I. Kundiev Institute of Occupational Health of the National Academy of Medical Sciences of Ukraine», Kyiv, Kalnish V. V.
Published: April 2021

Introduction. Temporary processes take place not only in the consciousness of a person - the entire organism and its components at the unconscious level are also somehow oriented in time. In the process of evolution in living systems, a certain way of responding to the prevailing external and internal situations has been formed, in the process of implementation of which a fundamental restruc-turing of the functional relationships of its subsystems is carried out. Therefore, the characteristics of the behavior of an organism in time are fundamental and integral for assessing its state and the form of orientation in time. The objective of the undertaken research is to develop an approach to retrospective assessment of the functional state of a person, taking into account the processes that occur before and after the period of time designated as «present». Methods and scope of research. The rhythmogram data and the calculation of its indicators were obtained as a result of an annual daily study (333 measurements of 5-minute heart rate segments) using the gythmograph apparatus. For further analysis, a well-known set of heart rate indicators was used, as well as a number of its new «temporal» characteristics: a function of the probabilities of two events in the «past» relative to the «present» and a function of the probabilities of two events in the «future» relative to the «present». Results and Conclusions. The studies carried out have shown the novelty and expediency of a retrospective analysis of heart rate variability from the standpoint of isolating the body’s reactions to «past» and «future» functional states that change depending on the transformations of environmental conditions during the year. The attractiveness of such an analysis lies in the fact that the obtained functions of the probability of occurrence of events in the «past» and «future» reflect the fundamental processes of integra-tion of various physiological processes in the body. The specifics of providing rigid and plastic processes occurring in the human body, accompanying their synchronization in the event of changes in environmental conditions, have been established. The possibility of classifying functional states according to the characteristics of the functions of probability of occurrence of events in the «past» and «future» has been revealed. Key words: Functional state; Rhythmogram; Past; Present; Future.
Evaluation of changes in the parameters of the vascular system in a reactive hyperemia test using rheographic data
Authors:   National Aerospace University «KhAI», Kharkiv, Ukraine, Kirichenko V. A. , Kulbashevskaya T. V. ,   National Aerospace University «KhAI», Kharkiv, Ukraine, Pechenin A. V. ,   National Aerospace University «KhAI», Kharkiv, Ukraine, Sergeev V. G. ,   National Aerospace University «KhAI», Kharkiv, Ukraine
Published: April 2021

Abstract Introduction. The task of searching method of non-invasive assessment of the cardiovascular system state is now as relevant as it was many years ago, since a method that fully satisfies the researchers is still not offered today. Once a popular rheographic method of studying the cardiovascular system today is increasingly being forgotten. A point of view was formed about its low effectiveness, due to the low accuracy and instability of the results obtained. Doppler analyzers widely used today give excellent results in the study of local vascular pathologies, but are of little use for an integral assessment of the state of vascular regions. Objective. Revealing the reasons for the low effectiveness of the rheographic method for assessing the state of the vascular system and determining ways to improve the method. Results of the research. On the example of the reactive hyperemia test data analysis, the inadequacy of the existing classical procedure for the analysis of rheograms is shown and the prospects for using the procedure for decomposing the rheogram into low-frequency (LF) and high-frequency (HF) components are shown. Conclusions. The use of rheography to assess the state of the cardiovascular system is very promising, but it requires fundamental changes in the existing classical methodology for the analysis and interpretation of rheograms. Based on the data of rheographic complex «ReoCom» results of using the technique of «LF-HF analysis» are given. The obvious advantages are shown, in comparison with the classical technique of rheogram analysis. Key words: Evaluation of the cardiovascular system parameters; Rheographic data; «LF-HF analysis» of rheograms; Vascular tone; Peripheral resistance; Venous outflow.
Use of innovative computer technologies in providing health monitoring of children and adolescents of school age
Authors:   SI «Institute of Children and Adolescent Health Protection», Kharkiv, Ukraine, Necheporenko N. I. , Peresypkina T. V. ,   SI «Institute of Children and Adolescent Health Protection», Kharkiv, Ukraine, Sidorenko T. P. ,   SI «Institute of Children and Adolescent Health Protection», Kharkiv, Ukraine
Published: April 2021

Introduction. The current achievements of modern science are the use of specialized automated systems and applications in various fields of medicine. In the current context of health care reform, the burden on health workers who provide medical care to school-age children is growing. The purpose of the work. With the declining level of children’s health, the system of optimizing the monitoring of children’s health and their physical development is becoming an urgent issue. Results. The proposed program is based on MS Access, VBA programming language. Designed for a comprehensive automatic assessment of physical development of students on the basis of anthropometric and physiometric indicators, functional capabilities of the body and the data of medical examination. The program provides the possibility of longitudinal observation (accumulation of data) on the health and physical development of students of an educational institution or classroom during the entire period of study of students. The result of the program is the formation of reports that describe the results of medical examinations to determine the proportion of students, physical or sexual development, visual or hearing acuity which meets or does not meet the normative age. Also, students who need further counseling from specialists in various fields are identified. Conclusions. The use of the proposed software will help to improve the organization of medical care by increasing the effectiveness of health monitoring and optimizing the work of health care workers or educational institutions. Key words: Medical examinations; Database; Software packages; Children’s health.
Model of functional system of adaptive control of student learning process in e-learning systems
Authors:   Zaporizhzhia State Medical University, Zaporizhzhia, Ukraine, Ryzhov O. A. , Ivankova N. A. ,   Zaporizhzhia State Medical University, Zaporizhzhia, Ukraine, Androsov O. I. ,   Zaporizhzhia State Medical University, Zaporizhzhia, Ukraine
Published: April 2021

Introduction. The current achievements of modern science are the use of specialized automated systems and applications in various fields of medicine. In the current context of health care reform, the burden on health workers who provide medical care to school-age children is growing. The purpose of the work. With the declining level of children’s health, the system of optimizing the monitoring of children’s health and their physical development is becoming an urgent issue. Results. The proposed program is based on MS Access, VBA programming language. Designed for a comprehensive automatic assessment of physical development of students on the basis of anthropometric and physiometric indicators, functional capabilities of the body and the data of medical examination. The program provides the possibility of longitudinal observation (accumulation of data) on the health and physical development of students of an educational institution or classroom during the entire period of study of students. The result of the program is the formation of reports that describe the results of medical examinations to determine the proportion of students, physical or sexual development, visual or hearing acuity which meets or does not meet the normative age. Also, students who need further counseling from specialists in various fields are identified. Conclusions. The use of the proposed software will help to improve the organization of medical care by increasing the effectiveness of health monitoring and optimizing the work of health care workers or educational institutions. Key words: Medical examinations; Database; Software packages; Children’s health.
Telerehabilitation: information and technological support, experience of application
Authors:   V. M. Glushkov Institute of Cybernetics of NAS of Ukraine, Kyiv, Palagin A. V. , Semikopnaya T.V. ,   V. M. Glushkov Institute of Cybernetics of NAS of Ukraine, Kyiv, Chaikovsky I. A. ,   V. M. Glushkov Institute of Cybernetics of NAS of Ukraine, Kyiv, Sivak O. V. ,   Center for psychological counseling and trauma therapy «Open Doors», Kyiv, Ukraine
Published: April 2021

Introduction. Telerehabilitation is a complex of rehabilitation exercises and training programs provided to the patient remotely using telecommunication computer technologies, mainly at the outpatient stage of treatment. Telerehabilitation must be accompanied by appropriate software. The purpose of the work. To give an idea of the high-tech platform for telerehabilitation, which is being created at the Institute of Cybernetics named after V. M. Glushkov National Academy of Sciences of Ukraine. Methods. Work is being carried out under a project of the National Research Foundation of Ukraine, which is called «Transdisciplinary Intelligent Information and Analytical System for Supporting Rehabilitation Processes in a Pandemic (TISP)». The peculiarity of the system is that it is based on knowledge-oriented technology, ontological engineering and trans-disciplinary paradigm. The cognitive services of the system implement structuring. and classification. information, synthesize the necessary documents based on semantic analysis, identify the characteristic properties of information processes and provide support for decision-making at all stages of their life cycle. Results. The absence of specialized scales for functional assessment of the cardiorespiratory system, suitable for use during telereha-bilitation, was revealed. The proposed technology of objective functional assessment of the patient at home, based on the use of several portable devices and an innovative system for scaling small ECG changes. The technology was tested in the process of rehabilitation of patients with PTSD in the Center for Psychological Counseling and Trauma Therapy «Open Doors» as a means of control in the process of psychodiagnostics and psychotherapy. Conclusion. 1. Telerehabilitation is the most modern type of rehabilitation, which is rapidly developing. 2. The V. M. Glushkov Insti-tute of Cybernetics of the National Academy of Sciences of Ukraine is creating a transdisciplinary intelligent information and analytical system for supporting rehabilitation processes in a pandemic (TISP), based on cognitive information technology, which fully provides the process of analyzing large volumes of information resources. 3. The technology of objective functional assessment of a patient at home, based on the use of portable devices and an original ECG scaling system, is an important component of telerehabilitation. Key words: Telerehabilitation; Novel coronavirus disease COVID-19; Post-traumatic stress disorder; Intelligent information and analytical system; Functional assessment; Scaling of the electrocardiogram and heart rate variability.
The psycho-religious mechanism behind suicide attacks: a mindsponge-based Bayesian statistical investigation and implications for the post-9/11 world
Authors: Vuong Quan-Hoang , Nguyen Minh-Hoang , Le Tam-Tri
Published: April 2021

The book examines the psycho-religious mechanism behind the violent extremism of suicide attacks in the post-9/11 world. It employs the mindsponge concept, an original dataset, and original research results obtained from the authors' statistical investigations using the Hamiltonian Markov chain Monte Carlo technique. It provides insights and implications for policymakers and strategists in their efforts to engage in peace talks and reduce violent conflicts worldwide. ================================================================== Quan-Hoang Vuong, Minh-Hoang Nguyen, Tam-Tri Le. (2021). A Mindsponge-Based Investigation into the Psycho-Religious Mechanism Behind Suicide Attacks. Warsaw, Poland: De Gruyter / Sciendo. https://doi.org/10.2478/9788366675599 Online ISBN: 9788366675599 *Amazon: https://www.amazon.com/dp/8366675580/
Optimizing the Kerr nonlinear optical performance of silicon waveguides with integrated graphene oxide films
Authors: Moss David
Published: April 2021

The Kerr nonlinear optical performance of silicon nanowire waveguides integrated with 2D layered graphene oxide (GO) films is theoretically studied and optimized based on experimentally measured linear and nonlinear optical parameters of the GO films. The strong mode overlap between the silicon nanowires and highly nonlinear GO films yields a significantly enhanced Kerr nonlinearity for the hybrid waveguides. A detailed analysis for the influence of waveguide geometry and GO film thickness on the propagation loss, nonlinear parameter, and nonlinear figure of merit (FOM) is performed. The results show that the effective nonlinear parameter and nonlinear FOM can be increased by up to ~52 and ~79 times relative to bare silicon nanowires, respectively. Self-phase modulation (SPM)-induced spectral broadening of optical pulses is used as a benchmark to evaluate the nonlinear performance, examining the trade-off between enhancing Kerr nonlinearity and minimizing loss. By optimizing the device parameters to balance this, a high spectral broadening factor of 27.8 can be achieved ‒ more than 6 times that achieved in previous experiments. Finally, the influence of pulse chirp, material anisotropy, and the interplay between saturable absorption and SPM is also discussed, together with the comparison between the spectral broadening after going through GO-coated and graphene-coated silicon waveguides. These results provide useful guidance for optimizing the Kerr nonlinear optical performance of silicon waveguides integrated with 2D layered GO films.
STRATEGI PENGAWASAN KEIMIGRASIAN SERTA PERAN HUKUM KEIMIGRASIAN DALAM MENGHADAPI ANCAMAN KEDAULATAN NEGARA DI INDONESIA
Authors: WarisulAmbia
Published: April 2021

Keimigrasian merupakan hal ihwal lalu lintas orang yang masuk atau keluar wilayah Indonesia serta pengawasannya dalam rangka menjaga tegaknya kedaulatan negara (UU No 6 Tahun 2011 pasal satu angka 1). Saat ini Total jumlah penduduk dunia tahun 2019 adalah sebanyak 7.714.576.923 dan terus bertambah tentunya. Bertumbuh 1.07 persen dibanding tahun 2018 atau bertambah 81.757.598 penduduk. Adapun jumlah usia rata-rata penduduk dunia menurut worldometers adalah 29,9 tahun. Ini merupakan suatu kondisi dimana siklus kepadatan dan lalu lintas orang di dunia semakin berkembang dan meningkat. Jumlah penduduk terbanyak masih didominasi Cina. Negara Tirai Bambu ini mencatatkan 1.417.930.226 jiwa penduduk. Total penduduk Cina lima kali lebih banyak dibandingkan jumlah penduduk Indonesia. Di peringkat dua, penduduk paling banyak di dunia ditempati oleh India. Penduduk India berjumlah 1.362.483.286 sejak artikel ini dibuat dan terus bertambah. India mengejar Cina yang hanya berjarak sekitar 50 juta penduduk. Indonesia merupakan negara peringkat ke 4 dengan jumlah penduduk terbanyak ke 4 di dunia dengan jumlah penduduk mencapai 257.912.349 jika di persenkan mencapai 3.44% penduduk bumi. Dengan adanya perkembangan globalisasi dan ekonomi yang kian meningkat dan jumlah peningkatan penduduk yang kian bertambah membuat manusia bermigrasi ke negara?negara lain. Dengan adanya dampak perubahan siklus perekonomian di setiap negara berbeda beda serta mobilitas sosial dan diferensiasi sosial juga ketimpangan sosial maka akan timbul kriminalitas di setiap negara. Kriminalitas bukan hanya dari segi ekonomi saja tetapi, bisa dari segi politik, sosial, serta berdampak juga terhadap keamanan negara. Dengan adanya hal tersebut, maka keimigrasian harus selektif dalam menerima orang asing (foreign) ke Indonesia, guna menjaga stabilitas keamanan negara dari ancaman, gangguan, dan hambatan dari luar.Kata kunci : Penegakan Hukum , Orang Asing , Keimigrasian , Kejahatan.
key genetic factors in the metabolic syndrome predisposition which may be a therapeutic options by gene therapy
Authors: Dowaidar Moataz
Published: April 2021

Metabolic syndrome affects 24–42 percent of individuals over the age of 50 in the United States. Dietary treatments tailored to the APOE genotype may help patients with MeS. Both mitotic and meiotic epigenetics are heritable. SREBP 1 and 2 genes overexpress in response to low cholesterol, statins, and insulin tolerance, resulting in decreased fatty acid oxidation, insulin signalling, and HDL-c levels. FTO is a key gene in the metabolic syndrome predisposition which may be a therapeutic option. MicroRNA repression of the VEGF 62 reference gene is prevented by the LncRNA MIAT/miR-150-5p complex. MEG3, a maternally expressed three-letter noncoding RNA, has been related to endothelial cell angiogenesis. Phosphorylation of p38 and JNK improved in the absence of (SRA) lncRNAs, resulting in decreased insulin signaling. Mipomersen is a 20-mer oligonucleotide that binds to the APOB mRNA's coding region. Volanersorsen has finished phase II and III clinical trials, making it the first APOC3 ASO to do so. ASO targeting APOB3 based on next-generation ligands is also in the early stages of research. Angptl3 is another successful genome editing target. Given the role of ANGPTL3 in TRL metabolism. Defects in the LDLR gene cause the most common genetic form of hypercholesterolemia, FH.
Genome editing's potential target diseases in the cardiovascular field
Authors: Dowaidar Moataz
Published: April 2021

Two types of cardiovascular diseases can be cured or prevented using genome editing. The liver is the organ that has received the most attention in terms of clinical genome editing for cardiovascular diseases. Off-target mutagenesis is a concern of any form of genome editing. Off-target mutations in target cells or tissues may lead to undesirable functional phenotypes, including cancer. For therapeutic editing of the heart, the authors claim it's critical to achieve high editing efficiency at a chosen genomic site in a desired tissue. Off-target editing can be tested genome-wide unbiasedly using newer cell-based methods. For low off-target impact, well-designed gRNAs are important. The delivery of genome editors to target tissues and cells is a significant barrier to clinical use.
Anti-sense pathways have been generated using siRNA. The liver and other organs will now be targeted by gene therapy.
Authors: Dowaidar Moataz
Published: April 2021

Novel RNA-based medicines also benefited from a greater understanding of how many different roles RNAs have. They are expected to be useful for objectives that have previously been considered inaccessible. In addition, siRNAs have been used to generate anti-sense pathways Different techniques may be used to administer this to tissues. Several options have emerged from the different plans and strategies described here. These method/methods, formulae, and dosages differ dramatically. The biggest challenge is delivering results. It is now possible to target the liver and other well-utilized organs, Adhesive high levels of discharge, for example, affect most body tissues. The use of nanoparticles with ligands can increase uptake in some tissues. In this process, processing, quality is a limitation on growth. Only specific structures should be targeted. Ribonucleic therapy has proven a therapeutic option for various conditions. Several hindrances get in the way of practical use. Clinical experiments are stopped due to medical concerns. To avoid side effects, future research will likely emphasize finding transmission to target tissues.
Researchers would be able to develop a detailed picture of chromatin in disease, which would be useful for gene therapy.
Authors: Dowaidar Moataz
Published: April 2021

Researchers would be able to produce an accurate picture of chromatin in disease by combining reported results with new measurements using existing databases. Data mining and the development of new databases will have an effect on how we address chromatin questions in the coming years. The QCBio Collaboratory at UCLA is a unique forum for non-programmers looking for training and collaboration to solve biological problems. Many bioinformatics tools are already available, and more will be developed as new knowledge becomes available. Scientists will continue to be motivated to test the most interesting hypotheses with the right instruments, exposing new insights into cardiac biology. Basic knowledge of how computers work and how to answer problems with big data will continue to inspire scientists to test the most important theories with the right tools, revealing novel insights into cardiac biology.
Kedudukan dan fungsi pemerintahan (Nomor 6 Tahun 2008 Tentang Urusan Pemerintah Kota Palembang bahwa bidang Komunikasi Dan informatika mempunyai kedudukan, Tugas dan Kewenangan)
Authors: P Muh Wahyu Ananda
Published: April 2021

Kepala Dinas berkedudukan di bawah dan bertanggung jawab kepada Walikota melalui sekretaris daerah
Preclinical studies and clinical trials have sparked interest in certain gene therapy strategies for atherosclerotic Coronary Heart Disease.
Authors: Dowaidar Moataz
Published: April 2021

In recent years, an amazing array of innovative therapeutic approaches has been built in our battle against atherosclerotic Coronary Heart Disease. These cutting-edge therapeutic methods range from vaccines to protein, mRNA, genome, and even DNA base modulation to treat atherosclerotic Coronary Heart Disease. Although the molecular targets studied by these approaches are largely the same, some of them are safer and more targeted against specific targets due to technical advantages and limitations. Preclinical studies and clinical trials have sparked interest in certain biological medications for the treatment of atherosclerotic Coronary Heart Disease, although others have stalled. With bated breath, we await the results of the clinical trial. Both of these treatment choices, however, have major disadvantages. As a result of their acquired experience and ongoing efforts to overcome them, their transition to the clinical community could be improved in the coming years.
Teaching and Learning activities that promote effective learning of Research Methodology among Psychology students
Authors: Mathews Minu
Published: April 2021

BackgroundCreating a conducive environment for learning cultivates engaged and independent learners, allowing for high-level learning (Warren, 2004). When assessing the diverse Psychology courses that exist, the evaluation of Research Methods (RM) teaching and its associated pedagogies is high on the agenda of college based Higher Education (Burton & Schonfield, 2011). ObjectiveThis study aimed at exploring what range of teaching and learning activities (TLA’s) promote effective learning of RM among Psychology students. Additionally, it aimed to understand, from a student perspective, what ‘effective learning’ meant in the context of RM. MethodA mixed methods approach comprising of both surveys as well as focus groups was conducted with undergraduate Psychology students. Thematic analysis and basic frequencies were used to analyse data. Results Results demonstrated that both student and teacher-led activities were beneficial and worked complementarily for students in their understanding of the subject whilst serving different purposes. Practical labs and class exercises were the top activities highlighted (student-led) followed by lectures and flow chart concept checks (teacher-led). Furthermore, ‘effective learning’ encapsulated not just a long-term knowledge acquisition of concepts but the ability to apply one’s knowledge to the wider context. Conclusion and teaching implication Findings are in line with the Conception of Learning which has a nested hierarchy consisting of both surface learning elements and deep learning (Marton,Dall’Alba & Beaty, 1993). RM has been identified as a difficult subject to teach as well for students to learn (Gray et al., 2015) and as a result this study teases apart some of the most beneficial techniques from a student perspective to be considered when designing the structure and delivery of RM courses.
Giovanni Bassano’s Divisions. A Computational Approach to Analyzing the Gap between Theory and Practice
Authors: Sela Sarig
Published: April 2021

“Division Ornamentation Practice” refers to the 16th-century phenomenon of embellishing a known melody in an extemporaneous or more pre-planned manner. 11 division instruction manuals were published by different performers during the 16th century and the first two decades of the 17th century. It is a common belief today that if performers wish to learn how to improvise divisions in a specific performer’s style, they need to practice the performer’s manual. In this paper, I challenge this assumption, demonstrating that, at least with the cornetist and composer Giovanni Bassano, there is an unsurmountable gap between his manual ornamentations, called here figurations, and the figurations he used in his division pieces. Surprisingly, in fact, Bassano uses less than 3% of his manual figurations in his division pieces. This raises the intriguing question of whether it is effective to practice Bassano’s manual figurations in learning to improvise in his style. I proposed three computational models to examine this question. None of them yield an overlapping ratio that suggests close affinity between the manual figurations and the division figurations that Bassano used in his division pieces. Moreover, I show that Bassano’s manual figurations are longer, faster and have a higher pitch range than the division figuration. Based on these findings, I recommend performers who wish to improvise in Bassano style to practice his figuration divisions rather than his manual figurations.
Rough Set Based Analysis of Document Images
Authors: Chaudhuri Ushasi
Published: April 2021

Rough set is a well-studied subject with a theoretical foundation and many applications. However, its usage in image processing has been very sparse. Most of the well-known algorithms for document image processing related to character recognition, character spotting, and logo retrieval resort to supervised classification, causing the system to slow down in the speed with increasing diversity in the documents, as well as the need to have a large training dataset. Hence, with an aim to resolve the tediousness and pitfalls of training, but without compromising on the efficiency, we introduce a rough-set-theoretic model. It is designed to perform an unsupervised classification of optical characters and logos with a small subset of attributes, called the semi-reduct. The semi-reduct attributes are mostly geometric and topological in nature, each having a small range of discrete values estimated from different combinatorial characteristics of rough-set approximations. This eventually leads to quick and easy discernibility of almost all the characters and logos. In this thesis, we first explain the basics of rough set theory. Subsequently, we propose various attributes that can be easily computed from the binary representation of the images. In subsequent chapters we show how one can select an appropriate subset of such attributes, known as semi-reduct, to perform a document processing task. We demonstrate in this thesis that using the above attributes one can design a character recognition system that is both computationally and storage efficient. Using a different semi-reduct, we show that one can also solve the very delicate task of character spotting in ancient inscriptions. Additionally, we propose appropriate pre-processing steps to binarize the old and dilapidated inscriptions. Finally, we propose a novel technique for logo retrieval using a suitably prepared semi-reduct. Comparison with other existing techniques substantiates our claim that attributes from the rough set are indeed good candidates for document image processing.
FORMATION OF SELF-ANALYSIS SKILLS DURING USING CRITICAL THINKING STRATEGIES IN LEARNING
Authors:   Biology teacher, Nazarbayev Intellectual School, Pavlodar, Kazakhstan, Altayeva I. B. , Zakanova A. N. ,   Biology teacher, Nazarbayev Intellectual School, Pavlodar, Kazakhstan
Published: April 2021

The main goals of this research are developing self-analysis skills through the using of critical thinking strategies in learning. The article presents the importance of self-analysis and the impact of reflection on the planning of further educational activities, managing education through the use of strategy data. The main critical thinking strategies are listed, special tools are identified and developed that are applicable in the study of an advanced biology course. A self-analysis table has been make, in accordance with the development of certain skills and abilities necessary for studying an advanced biology course and preparing for formative, summative assessments and an international exam.
THE ISSUE OF LEARNING AND TEACHING A FOREIGN LANGUAGE
Authors:   Azerbaijan state university of oil and industry, Azerbaijan, Charkazova Sevda
Published: April 2021

The article deals with the issue of teaching a foreign language in connection with the need to form students of certain competencies that allow them to participate in a new society based on knowledge. A complex of problems associated with teaching and learning a second foreign language is discussed, and ways to solve them are proposed.
Analisis Variabel Yang Mempengaruhi Earning Per Share (EPS) Pada Industri Food and Beverage Di Indonesia Tahun 2013-2017
Authors: Alfisah Erni , Kurniaty Kurniaty
Published: April 2021

The purpose of this study was to examine and analyze the effect of Current Ratio (CR), Debt to Equity Ratio (DER), Return on Equity ((ROE), and Net Profit Margin (NPM) on Earning Per Share (EPS) either partially or simultaneously. The research object used is the food and beverage industry which is listed on the IDX from 2013 to 2017. The type of research carried out is descriptive quantitative. The sample obtained after being carried out with a purposive sampling approach is 14 companies. The data used is secondary data in the form of reports financial industry food and beverage for the observation period. In this study, there are four variables, namely ROE, CR, DER, NPM as the independent variable and EPS as the dependent variable. The analysis techniques used are econometric analysis or classical assumption test, multiple regression, test of the coefficient of determination, and simultaneous test The results showed that the variables DER (X2) and ROE (X3) are partially significant significant effect on EPS (Y1), while the variables CR (X1) and NPM (X4) do not have a significant effect on EPS (Y1) and simultaneously CR, DER, ROE, and NPM have a significant effect on EPS.Keywords: Current Ratio, Debt to Equity Ratio, Return on Equity, Net Profit Margin, Earning per share
AIR MANCUR OTOMATIS DENGAN MUSIK BERBASIS ARDUINO
Authors: Ratna Silvia
Published: April 2021

AbstrakAir mancur banyak digunakan di taman-taman sebagai hiasan taman. Banyak metode yang sudah dilakukan misalnya pancaran air mancur tidak bervariasi sehingga hiasan taman dalam waktu yang lama kurang menarik. Pada penelitian ini pengaturan air mancur yang dapat bervariasi dengan menggunakan irama musik yang diputar melalui aplikasi android dengan cara menghubungkan nya dengan bluetooth dan file lagu diletakan pada modul DF player. Tahapan-tahapan yang dilakukan: masukan sumber musik, Arduino Uno, DF player mini, bluetooth, Transistor TIP 31C, Pompa Air, Sumber Air dan aplikasi android. Dengan bervariasi irama musik maka bervariasi tegangan masukan kesistem dengan pengontrolan menggunakan arduino uno maka sistem mampu mengatur kerja Transistor  sehingga pompa air dapat diatur, akhirnya irama musik dapat mengatur keluaran air bervariasi menyerupai air mancur. Kata kunci: air mancur, df player, musik, pompa air
APLIKASI BIMBINGAN SKRIPSI STUDI KASUS FAKULTAS TEKNOLOGI INFORMASI UNISKA UNTUK KEEFEKTIVITAS WAKTU SELESAI MASA BIMBINGAN
Authors: Zaenuddin Zaenuddin , Mahalisa Galih
Published: April 2021

ABSTRAK Aplikasi adalah suatu program komputer yang dibuat untuk mengerjakan dan melaksanakan tugas khusus dari pengguna khususnya pada studi kasus yang ada pada Fakultas Teknologi Informasi UNISKA. Perlunya sebuah aplikasi bantuan untuk mengatasi efisiensi waktu pada saat bimbingan skripsi bisa dilihat dari hasil obsevasi yaitu sebanyak 82% dari 20 responden kurang puas dengan metode konvensional yang digunakan saat ini terutama masalah efektivitas masa bimbingan. Hasil yang didapatkan berdasarkan analisa dari implementasi dan pengujian menggunakan metode Standart ISO 9126 pada aplikasi tersebut maka didapatkan sebanyak 131 sample yang terdiri dari 18 dosen, 120 mahasiswa, dan 1orang staf FTI, salah satu pengujian dengan hasil dari pengujian functionality menyatakan 93% termasuk skor baik, pengujian usability menyatakan 83% termasuk baik. Maka dari itu hasil observasi setelah menggunakan aplikasi dilakukan perhitungan ulang dari 20 responden presentase  90% menyatakan respon yang bagus untuk bisa menggunakan aplikasi ini sebagai alat pendamping dalam melakukan konsultasi skripsi secara online. Kata Kunci : aplikasi, skripsi, efisiensi, waktu, efektivitas, konsultasi, online
APLIKASI PENGELOLAAN PELAKSANAAN PROYEK BERBASIS WEB PADA CV. PUTERI MURAKATA
Authors: Rahman Fauzi Yusa
Published: April 2021

ABSTRACT CV. Puteri Murakata adalah perusahaan yang bergerak pada bidang general suplier dan  kontraktor yang melayani perusahaan menengah dan perusahaan besar, baik swasta dan pemerintahan. Saat ini pengelolaan data pada CV. Puteri Murakata  masih  dilakukan melalui pembukuan yang ditulis secara manual.Hal ini tentu saja memiliki banyak kekurangan, komputerisasi merupakan cara tepat untuk mengatasi permasalahan  ini. Aplikasi berbasis web untuk  menggantikan  pekerjaan  yang  awalnya masih secara manual sekarang menjadi berbasis komputer. Aplikasi tersebut diharapkan dapat mempermudah dan dapat mengatur jalannya proses pengelolaan data pada  CV. Puteri Murakata. Kata kunci : Aplikasi, Proyek, Web.
APLIKASI SISTEM PENGELOLAAN PANTI SOSIAL BINA REMAJA “BUDI SATRIA” BANJARBARU BERBASIS WEB
Authors: Ibrahim Ibrahim
Published: April 2021

Abstrack  Aplikasi pengelolaan dinas sosial yang ada pada Panti Sosial Bina Remaja (PSBR) “Budi Satria” Banjarbaru Provinsi Kalimantan Selatan ini masih menggunakan sistem yang manual. Hal ini menimbulkan beberapa kendala yang cukup merepotkan, terutama pada ketidakvalidan dan ketidakcocokan data. Sering pula terjadi kendala pada saat pencarian informasi tentang data-data siswa, data-data setiap pengajar, maupun pada saat ingin menginput suatu data.Demikian pula halnya dengan penyediaan data, misalnya data siswa jurusan, data tempat magang siswa dan siswa magang, data siswa jurusan, siswa asrama, dan data penyalur ataupun pengajar. Maka pada penelitian/skripsi ini dibuatlah aplikasi pengelolaan berbasis web yang dapat mempermudah petugas dalam menginput data secara cepat, tepat dan efisien.Aplikasi yang dibangun ini, dibuat dengan menggunakan tools seperti sublime, PHPMyAdmin, MySQL sebagai database dengan bahasa pemprograman HTML dan PHP, dan dirancang dengan alur serta rancangan antar muka yang sederhana menggunakan metode perancangan meliputi, perancangan DFD, Flowchart, struktur tabel database dan  beberapa perancangan diagram-diagram lainnya yang menjelaskan alur berjalannya aplikasi pengelolaan ini, sehingga dapat dengan mudah digunakan di lingkungan panti sosial.  Kata Kunci : HTML, MySQL, Web Aplikasi, Pengelolaan PSBR “Budi Satria”  dan PHP