bluuebunny/crossref_metadata_2025 huggingface dataset:
Network Pharmacology and Molecular Docking to Unveil the Mechanism of
Shudihuang against Amyotrophic Lateral Sclerosis
Authors: Wu Haidong , Wang Tong , Li Xiaojing , Tian Yueqin
Published: June 2023

Background:

Shudihuang has been clinically proven to be an effective Chinese medicine compatible with the treatment of amyotrophic lateral sclerosis. However, the underlying mechanism of Shudihuang against amyotrophic lateral sclerosis remains unclear.

Objectives:

The present study aims to elucidate the possible mechanism of Shudihuang in treating ALS using network pharmacology and molecular docking.

Methods:

The primary active components of Shudihuang and their relevant targets were identified by the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP) and the Swiss Target Prediction database, respectively. The ALS-related targets were obtained from the Disgenet and OMIM databases. The shared targets were derived by the intersection of disease-associated and component-associated targets and then introduced into the Cytoscape software to construct a network of drug-component-target. In addition, protein interaction relationships among the shared targets were analyzed by the STRING and Cytoscape software. Furthermore, the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway and Gene Ontology (GO) functional enrichment analysis were conducted by the Metascape platform. The binding activities between the hub targets and the active components were assessed with molecular docking.

Results:

Dousterol and glutathione were identified as the core components of Shudihuang, and the hub targets of ALS are PTGS2, PPARG, ESR1, IGF-1R, and MAPK3, with the highest degrees in the PPI network. The finding that dousterol and glutathione had a good affinity with PTGS2, PPARG, ESR1, IGF-1R, and MAPK3 also supported this. Finally, it was revealed that Shudihuang treatment of ALS predominantly involves estrogen-related pathways such as nuclear receptor activity and steroid binding.

Conclusion:

In summary, this study suggested that the main active components of Shudihuang (stigmasterol and sitosterol) may exert a critical effect in ALS treatment by binding to hub targets (PTGS2, PPARG, ESR1, IGF-1R, and MAPK3) and then modulating estrogen receptor-related pathways to attenuate glutamate excitotoxicity, inhibit oxidative stress and antagonize inflammation.
The Effect of PEGylation on Drugs’ Pharmacokinetic Parameters; from
Absorption to Excretion
Authors: Khajeei Ali , Masoomzadeh Salar , Gholikhani Tooba , Javadzadeh Yousef
Published: June 2023

Until the drugs enter humans life, they may face problems in transportation, drug delivery,
and metabolism. These problems can cause reducing drug’s therapeutic effect and even increase its side
effects. Together, these cases can reduce the patient's compliance with the treatment and complicate the
treatment process. Much work has been done to solve or at least reduce these problems. For example,
using different forms of a single drug molecule (like Citalopram and Escitalopram); slight changes in
the drug’s molecule like Meperidine and α-Prodine, and using carriers (like Tigerase®). PEGylation is a
recently presented method that can use for many targets. Poly Ethylene Glycol or PEG is a polymer that
can attach to drugs by using different methods and resulting sustained release, controlled metabolism,
targeted delivery, and other cases. Although they will not necessarily lead to an increase in the effect of
the drug, they will lead to the improvement of the treatment process in certain ways. In this article, the
team of authors has tried to collect and carefully review the best cases based on the PEGylation of drugs
that can help the readers of this article.
Edible Herbal Medicines as an Alternative to Common Medication for
Sleep Disorders: A Review Article
Authors: Hosseini Azar , Mobasheri Leila , Rakhshandeh Hassan , Rahimi Vafa Baradaran , Najafi Zohreh , Askari Vahid Reza
Published: June 2023

Insomnia is repeated difficulty in falling asleep, maintaining sleep, or experiencing lowquality
sleep, resulting in some form of daytime disturbance. Sleeping disorders cause daytime fatigue,
mental confusion, and over-sensitivity due to insufficient recovery from a sound sleep. There are some
drugs, such as benzodiazepines and anti-histaminic agents, which help to sleep induction and insomnia
cure. However, the prolonged administration is unsuitable because of tolerance and dependence.
Therefore, the researchers attempt to find new medicines with lesser adverse effects. Natural products
have always been good sources for developing new therapeutics for managing diseases such as cancer,
cardiovascular disease, diabetes, insomnia, and liver and renal problems. Ample research has justified
the acceptable reason and relevance of the use of these herbs in the treatment of insomnia. It is worth
noting that in this study, we looked into various Persian herbs in a clinical trial and in vivo to treat insomnia,
such as Artemisia annua, Salvia reuterana, Viola tricolor, Passiflora incarnata, lettuce, and
Capparis spinose. According to research, herb extracts and fractions, particularly n-butanol fractions
with non-polar agents, impact the benzodiazepine receptors and have hypnotic properties. Also, alkaloids,
glycosides, flavonoids, saponins, and tannins in practically every plant are mentioned making
them the popular natural compounds to help with sleep disorders and promote calmness.
Pyrene Appendant Triazole-based Chemosensors for Sensing Applications
Authors: Maddeshiya Tarkeshwar , Jaiswal Manoj K. , Tamrakar Arpna , Mishra Gargi , Awasthi Chhama , Pandey Mrituanjay D.
Published: June 2023

Over the last two decades, the design and development of fluorescent chemosensors for the targeted detection of Heavy Transition-metal (HTM) ions, anions, and biological ana-lytes, have drawn much interest. Since the introduction of click chemistry in 2001, triazole moie-ties have become an increasingly prominent theme in chemosensors. Triazoles generated via click reactions are crucial for sensing various ions and biological analytes. Recently, the number of studies in the field of pyrene appendant triazole moieties has risen dramatically, with more sophisticated and reliable triazole-containing chemosensors for various analytes of interest de-scribed. This tutorial review provides a general overview of pyrene appendant-triazole-based chemosensors that can detect a variety of metal cations, anions, and neutral analytes by using modular click-derived triazoles.
Association between Self-perceptions of Periodontal Health and Electronic Cigarette use in Young Adults
Authors: Miguras Maite , Leon-Rios Ximena Alejandra
Published: June 2023

Background:

The present study aimed to determine the association between self-perceptions of periodontal health and electronic cigarette use.

Material and Methods:

The study used an observational, analytical and cross-sectional design. 189 young adults aged 18 to 29 from the Metropolitan area of Lima, Peru, were recruited. In order to evaluate self-reported periodontal health, a questionnaire conceived by Quiroz et al. (2017) was used. This includes 13 questions divided into two dimensions (habits and self-perceived periodontal health). Poisson regression with robust variance was used to examine associations between qualitative variables and calculate raw and adjusted prevalence ratios.

Results:

59.46% of participants using electronic cigarettes were found to have a poor perception of gum health. Statistically significant associations were produced between poor perceptions of gum health and vaping, regarding both raw data (PR=0.81; 95% CI: 0.69-0.95; p=0.011) and data adjusted to consider covariates (PR=0.82; 95% CI: 0.69-0.97; p=0.021). No associations were observed for the dimensions of bleeding during brushing, reddish, and/or swollen gums.

Conclusion:

A relationship was found between poor perceptions of gum health and electronic cigarette use.
Evaluation of Knowledge, Awareness, Preparedness, and Measures among Dental Technicians Attending COVID-19 in Jordan
Authors: Bakri Isra Abdulkarim AL , Khader Yousef , Al Hourani Zeid Ahmad , Alshatrat Sabha Mahmoud
Published: June 2023

Introduction:

During the pandemic of COVID-19, Jordan imposed strict measures and abandoned selected medical procedures. Due to the high risk of cross-infection among dental team members, dental clinics and laboratories were subjected to definite regulations before being allowed back to work.

Aims:

This survey aims to assess the knowledge, awareness and preparedness of dental technicians in Jordan regarding COVID-19. Also, to investigate prevention measures for dental technicians working during the COVID-19 pandemic.

Methods:

A cross-sectional self-administered online survey was distributed electronically as a Google formviasocial media platforms. The study population consisted of registered dental technicians working in public and private laboratories in Jordan. The questionnaire consisted of a series of questions; demographic characteristics; knowledge and awareness about COVID-19, and the preparedness and measures to practice dental laboratory procedures during the pandemic.

Results:

This study included a total of 90 dental technicians (31 females and 59 males); their ages ranged from 22-60 years old. Almost all the participants (90%) were found knowledgeable about COVID-19. Governmental organizations, and visual and social media were the main sources of information. The majority of participants (>85%) encouraged drifting to digital dental technology protocols during COVID-19 pandemic. More than 65% of the participants reported COVID-19 very dangerous and considered themselves in a high risk of COVID-19 transmission.

Conclusion:

Most dental technicians have sufficient knowledge about COVID-19. However, most of them are not prepared to deal with impressions, restorations, and dentures of infected/suspected cases. Educational and training programs regarding COVID-19 among dental technicians are significantly needed.
Assessment of General Dentists' Knowledge and Confidence towards Dental Implants and their Perceptions regarding Undergraduate Education
Authors: Alsharif Shahad B. , Muthaffar Sarah , Aljahdali Raghad
Published: June 2023

Background:

Dentists are the primary sources of information regarding dental implants. Thus, they are required to be knowledgeable to meet patients’ expectations.

Objective:

This cross-sectional study aims to evaluate dentists’ knowledge and confidence in dental implants and investigate their perceptions regarding their undergraduate education.

Methods:

The study utilized a voluntary anonymous questionnaire, distributed among dentists, and graduates of King Abdulaziz University, Faculty of Dentistry, Jeddah, Saudi Arabia. The questionnaire sections were: demographics, perception regarding undergraduate education, confidence, and knowledge assessment. Descriptive statistics and Chi-square test at a statistical significance of P-value <0.05 were conducted.

Results:

The majority 75.5% reported sufficient theoretical information regarding implant dentistry during undergraduate education. However, only 12.2% reported sufficient clinical education. Limited participants had the chance to practice implant dentistry. About half of the participants 44.9% wished they were given this opportunity. Participants’ confidence in different procedures ranged between 45.9% and 82.6%. Survey participants reported adequate knowledge in treatment planning 82.7%, in prosthetics 92.9%, and 79.6% in surgical aspects. No association was found between gender and knowledge sections, treatment planning, prosthetic, and surgical aspects of implant dentistry. Respective P-values were 0.45, 0.14, and 0.09.

Conclusion:

Participants were interested to obtain more clinical experience in implant dentistry during undergraduate education. Thus, adjustments are suggested to optimize the quality of education to meet graduates’ expectations.
Selection of promotional media on tourist boats with fuzzy AHP and fuzzy TOPSIS
Authors: Utomo Dutho Suh , Cahyadi Dedy , Astuti Indah Fitri , Putra Gubtha Mahendra
Published: June 2023

The tourism sector necessitates effective promotion to introduce tourist attractions, including tourist boats operating on the Mahakam River. Given the prevalence of the digital era, it is imperative to employ appropriate promotional channels that precisely target the intended audience. The selection of promotional media entails various criteria and alternatives, thereby making it highly suitable to employ a multi-criteria decision-making approach. Due to the inherent uncertainty in assessments, a fuzzy scale becomes indispensable. This research utilizes a combination of Fuzzy Analytic Hierarchy Process (Fuzzy AHP) and Fuzzy Technique for Order of Preference by Similarity to Ideal Solution (Fuzzy TOPSIS) to address this issue. The findings of this study reveal that the order of importance for the criteria is as follows: Audience fit (C1), Reach (C2), Interactivity (C3), Cost (C4), Look and Feel (C5), and Frequency (C6). Regarding the selection of promotional media, social media (A1) emerges as the most effective medium when compared to web-based platforms (A2) and mobile applications (A3). The amalgamation of these two methodologies (Fuzzy AHP and Fuzzy TOPSIS) for the purpose of selecting tourism promotion media in Indonesia remains largely unexplored in prior research. Therefore, this study exhibits novelty and contributes to the existing knowledge concerning Multicriteria Decision Making and the selection of tourism promotion media in Indonesia.
Factores que influyen en la educación financiera de los jóvenes de Celaya, Guanajuato, México
Authors: Merino González Emma Liliana
Published: June 2023

La educación financiera se ha convertido en un elemento diferenciador en el desarrollo económico de los países y México ha tomado medidas que no han sido suficientes. Esta investigación tiene el objetivo de identificar qué factores influyen en el nivel de educación financiera de los jóvenes pertenecientes a la generación Z en el municipio de Celaya, Guanajuato, México. Con un enfoque cuantitativo, de diseño no experimental y alcance correlacional. Los resultados muestran que los jóvenes no cuentan con los conocimientos necesarios para tomar buenas decisiones financieras, además, que el nivel educativo de la madre influye en el nivel que poseen estos jóvenes. Se recomienda que se ajusten los planes y programas de estudio para que se impartan materias relativas al tema desde la educación básica. Una limitación del presente fue la recolección de los datos que se realizó mediante encuestas en línea debido a las condiciones actuales de pandemia. Se concluye se debe fortalecer la competencia financiera, sobre todo enfocada en las prácticas o comportamientos financieros positivos.
Cultivo: manejo del barrenador Diatraea ssp
Authors: Barona Rodríguez Ayda Fernanda , Antolinez Sandoval Eduar Yovany , Barreto Triana Nancy del Carmen , López González Ximena , Avendaño Avendaño Diego Fernando
Published: June 2023

Para el manejo integrado del complejo de barrenadores, realice control cultural mediante el uso de semilla sana, buena preparación del lote y destrucción de residuos de cosecha.
Balance Social 2020
Authors:   Corporación Colombiana de Investigación Agropecuaria - AGROSAVIA
Published: June 2023

El Balance Social de AGROSAVIA 2020 nos deja nuevas enseñanzas, no solo sobre cómo el conocimiento acumulado a lo largo del tiempo y las tecnologías son esenciales para reaccionar mejor ante eventualidades y ser resilientes, sino de la gran tenacidad del campo colombiano.
Comparison of Exergames Versus Conventional Exercises on the Health Benefits of Older Adults: Systematic Review With Meta-Analysis of Randomized Controlled Trials
Authors: Chen Xi , Wu Lina , Feng Hui , Ning Hongting , Wu Shuang , Hu Mingyue , Jiang Dian , Chen Yifei , Jiang Yu , Liu Xin
Published: June 2023

Background

Conventional exercises (CEs) can provide health benefits for older adults, but the long-term exercise adherence rate is low. As an emerging, stimulating, and self-motivating strategy, exergames (EGs) are defined as combinations of exercises and games that users carry out through physical actions. They can promote exercise, but the health effects of EGs versus CEs on the physical function and mental health (cognitive function, depression, and quality of life) of older adults remain controversial.

Objective

The aim of the study is to compare the health benefits of EGs versus those of CEs for the physical function and mental health of older adults.

Methods

A comprehensive search was conducted from the earliest available date to February 2023 in the following 6 databases: PubMed, Web of Science, Embase, Cochrane, CINAHL, and PsycINFO. All English-language randomized controlled trials comparing the effects of EGs versus those of CEs on the physical function and mental health of older adults, with nearly same physical activity between the 2 interventions, were included. Risk of bias was independently evaluated by 2 authors using the Cochrane risk of bias in randomized trials tool. Two authors independently extracted data. We followed the Cochrane Handbook of Systematic Reviews of Interventions to process and analyze the data for meta-analysis. Standardized mean differences (SMDs) and 95% CIs were used for continuous data, and random models were used for analyses.

Results

We included 12 studies consisting of 919 participants in total. Of these, 10 studies were eventually included in the meta-analysis. The results showed that EGs versus CEs exhibited no significant differences in physical (P=.13; τ2=0.31; χ26=26.6; I2=77%; SMD=0.37; 95% CI –0.11 to 0.86) or cognitive function (P=.63; τ2=0.01; χ23=3.1; I2=4%; SMD=0.09; 95% CI –0.27 to 0.44) effects.

Conclusions

Our findings indicate no significant difference between EGs and CEs in improving the physical function and cognitive function of older adults. Future studies are required to compare the effects of EGs versus those of CEs on cognitive function according to cognitive status, quantify the “dose-effect” relationship between EGs and health benefits, and evaluate the effects of different types and devices of EGs with regard to the health benefits of older adults.

Trial Registration

PROSPERO CRD42022322734; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=322734
A Mobile Medication Support App and Its Impact on People Living With HIV: 12-Week User Experience and Medication Compliance Pilot Study (Preprint)
Authors: Suzuki Mai , Yamanaka Kou , Fukushima Shinichi , Ogawa Mayu , Nagaiwa Yuki , Naito Toshio
Published: June 2023

BACKGROUND

The continuity of care between hospital visits conducted through mobile apps creates new opportunities for people living with HIV in situations where face-to-face interventions are difficult.

OBJECTIVE

This study investigated the user experience of a mobile medication support app and its impact on improving antiretroviral therapy compliance and facilitating teleconsultations between people living with HIV and medical staff.

METHODS

Two clinics in Japan were invited to participate in a 12-week trial of the medication support app between July 27, 2018, and March 31, 2021. Medication compliance was assessed based on responses to scheduled medication reminders; users, including people living with HIV and medical staff, were asked to complete an in-app satisfaction survey to rate their level of satisfaction with the app and its specific features on a 5-point Likert scale.

RESULTS

A total of 10 people living with HIV and 11 medical staff were included in this study. During the trial, the medication compliance rate was 90%, and the mean response rates to symptom and medication alerts were 73% and 76%, respectively. Overall, people living with HIV and medical staff were satisfied with the medication support app (agreement rate: mean 81% and 65%, respectively). Over 80% of medical staff and people living with HIV were satisfied with the ability to record medications taken (9/11 and 8/10 medical staff and people living with HIV, respectively), record symptoms of concern (10/11 and 8/10),and inquire about drug combinations (8/10, 10/10). And further, 90% of people living with HIV were satisfied with the function for communication with medical staff (9/10).

CONCLUSIONS

Our preliminary results demonstrate the feasibility of the medication support app in improving medication compliance and enhancing communication between people living with HIV and medical staff.
COVID-19 pandemic course 2020-2022: description by methods of mathematical statistics and discrete mathematical analysis
Authors: Gvishiani Alexei , Odintsova Anastasiya , Rovenskaya Elena , Boyarshinov Grigory , Belov Ivan , Dobrovolsky Michael
Published: June 2023

The paper describes the course of the COVID-19 pandemic using a combination of mathematical statistics and discrete mathematical analysis (DMA) methods. The method of regression derivatives and FCARS algorithm as components of DMA will be for the first time tested outside of geophysics problems. The algorithm is applied to time series of the number of new cases of COVID-19 infections per day for some regions of Russia and the Republic of Austria. This allowed to assess the nature and anomalies of pandemic spread as well as restrictive measures and decisions taken in terms of the administration of countries and territories. It was shown that these methods can be used to identify time intervals of change in the nature of the incidence rate and areas with the most severe course of the epidemic. This made it possible to identify the most significant restrictive measures that allowed to reduce the growth of the disease.
The influence of hormonal status on the hepatotropic effect and metronidazole in chronic liver damage and the administration of placenta cryoextract
Authors: Koshurba I.V. , Hladkykh F.V. , Chyzh M.O.
Published: June 2023

Background. Liver diseases occupy an important place in the structure of gastrointestinal pathology and remain an important medical and social problem throughout the world. Almost half of patients with manifest disorders of the hepatobiliary system have a polymorbid status or a high risk of developing concomitant pathology. One of the variants of the combined pathology in the clinic of gastroenterology is peptic ulcer on the background of liver disorders. As a potential anti-ulcer biotechnological agent with a hepatoprotective effect, cryocell — placenta cryoextract, a domestic drug, attracted attention. The purpose was to determine the gender aspects of the hepatotropic effect of placenta cryoextract in tetrachloromethane hepatitis with background ethanol-induced liver cirrhosis and liver damage by antiulcer agents. Materials and methods. Hepatotropic effects were studied at different levels of sex hormones in 112 male and female rats weighing 200–220 g, divided into 4 groups of 28 animals each. Tetrachloromethane hepatitis with background ethanol-induced liver cirrhosis was simulated by administration of an oily solution of tetrachloromethane in combination with a 5.0% ethanol solution for 45 days. Modulation of the content of sex hormones was achieved by surgical ovariectomy or orchiectomy. The activity of γ-glutamyl-transpeptidase was determined by the spectrophotometric method according to G. Szasz.
Diagnostic accuracy of computer morphometry for steatosis and fibrosis assessment in patients with chronic liver disease of various etiologies
Authors: Stepanov Yu.M. , Didenko V.I. , Gaydar Yu.A. , Zavhorodnia N.Yu. , Petishko O.P.
Published: June 2023

Background. Accurate assessment of the fibrosis stage is crucial for effective treatment. Histological examination, the primary method used for assessing liver fibrosis, has certain limitations due to variation within each stage. Computer morphometry offers an objective and quantitative approach to complement histological analysis, providing additional diagnostic information. The purpose of this study was to analyze the computer morphometry data in patients with chronic liver diseases (CLD) of different etiologies and determine their diagnostic accuracy for liver fibrosis diagnosis. Materials and methods. Seventy-five patients with CLD, namely 24 with non-alcoholic fatty liver disease (NAFLD), 8 with alcoholic liver disease (ALD), 1 with toxic hepatitis, and 42 with chronic hepatitis C (CHC), were included in the study. Percutaneous liver biopsy was performed under ultrasound guidance using a semi-automatic needle Colt Shot 16 G. The severity of fibrosis was assessed using the Metavir scale. For computer morphometry, biopsies were photographed and evaluated using the ImageJ 1.45S program (National Institutes of Health, USA). The computerized fibrosis index (CFI), steatosis index, and the number of apoptotic cells in 5 consecutive high-power fields were calculated. Receiver operating characteristic analysis was performed for CFI diagnostic accuracy assessment. Results. Advanced liver fibrosis (F3-F4) was diagnosed in 62.5 % of ALD cases and 31.0 % of CHC. The highest CFI was found in ALD, it exceeded the level of NAFLD and CHC patients by 3.3 (p < 0.01) and 2 times (p < 0.05), respectively. At the same time, people with NAFLD had the highest steatosis index (0.36 ± 0.11), which was 1.7 times higher (p < 0.05) than in ALD and CHC. Moreover, CFI correlated with the fibrosis stage (r = 0.71, p < 0.05). Stage I of liver fibrosis according to the Metavir scale is characterized by CFI up to 0.040, stage II — 0.041–0.130, stage III — 0.131–0.219, and stage IV — more than 0.220. CFI cut-off value was 0.017, which confirms the presence of liver fibrosis in patients with chronic liver diseases regardless of the etiology (sensitivity — 85.2 %, specificity — 100.0 %). Conclusions. Computer morphometry significantly improves the accuracy and reliability of histological examination, and allows to objectify morphological assessment of liver steatosis and fibrosis and to ensure long-term storage of the results.
Features of the intestinal microbiome in patients with gluten-sensitive diseases who are on a gluten-free diet
Authors: Gubska O.Yu. , Kuzminets A.A. , Denesyuk O.R. , Koliada O.K. , Moseyko V.V. , Dolko O.A.
Published: June 2023

Background. Intestinal dysbiosis is associated with violating both quantitative and qualitative intestinal microbiome (IM) composition. It accompanies different gastrointestinal disorders, including non-celiac gluten sensitivity (NCGS) and celiac disease (CD). A gluten-free diet is the only existing treatment for CD and NCGS. One of the questions of interest is the characteristics of the IM of patients with gluten-related diseases and its relationship with diet therapy. Materials and methods. The study included 25 adults, 14 (56 %) with CD and 11 (44 %) with NCGS; all were on agliadin diet. We determined the faecal content of the Bacteroidetes, Firmicutes, and Actinobacteria and the rest bacterial DNA (“other” indicator) using the real-time polymerase chain reaction. Results. The Bacteroidetes content was 28.4 (Q1-Q3 9.195–37.83) % in CD and 24.98 (Q1-Q3 9.615–30.597) % in NCGS patients, p = 0.565. Firmicutes content was 53.47 (Q1-Q3 49.98–56.798) % in CD patients and 53.0 (Q1-Q3 48.12–68.53) % in NCGS, p = 0.763. The Actinobacteria content was 4.8 (Q1-Q3 3.82–6.84) % in CD patients and 5.37 (Q1-Q3 4.09–7.77) % in NCGS, p = 0.572. There was a moderate positive correlation with the diet duration (p = 0.397, p = 0.03). The Firmicutes/Bacteroidetes ratio was 1.996 (Q1-Q3 1.35–6.85) in CD patients and 2.0 (Q1-Q3 1.65–7.58) in NCGS patients, p = 0.681. The content of “other” types of IM was 15.39 (Q1-Q3 7.44–22.33) % in CD patients and 13.78 (Q1-Q3 10.65–15.58) % in NCGS patients, p = 0.936. Conclusions. We found similar intestinal microbiome features in patients with celiac disease and non-celiac gluten sensitivity. The detected intestinal microbiome changes are most likely to be a consequence of dietary features in such patients, namely the side effect of maintaining an agliadin diet.
English Academic Writing Performance Level of KSU Students
Authors: Y. Cosmiano Lourdes Adeline Nicole
Published: June 2023

Linguists and scholars have been studying the influence of English language competency on numerous domains such as academic performance and employability for many years. While early researchers suggested that English proficiency did not predict high academic ratings and employment aptitude, evidence now shows that English proficiency is a cutting-edge asset in areas of academic success and employment in highly competitive and demanding industries in various fields of specialization. This is descriptive-evaluative research that employed a survey to investigate the English proficiency level and the relationship between English proficiency and academic accomplishment of technical writing students. In this study, a non-probability sampling strategy, namely the purposive sampling technique, was used. The findings show majority of respondents are proficient at English grammar and reading but have a low degree of competency in writing. Only grammar had an effect on the respondents' sex profile out of the three English competence levels tested. The survey also indicated that respondents' English proficiency levels (grammar, reading, and writing) are highly connected to their academic accomplishment. It is recommended that a more thorough evaluation and analysis be conducted in order to identify real variables and predictors that would truly affect and influence students' levels of proficiency and academic achievement, ultimately creating and producing the best teaching and learning enhancement program.
Estatuto normativo de las penas conjuntas y alternativas en la legislación penal chilena
Authors: Carrasco-Jiménez Edison
Published: June 2023

The criminal penalties that Chilean and Spanish criminal legislation refer to as combined sentences and alternative sentences are addressed. First, in order to describe their legal framework and, then, to present the criticisms raised against them by the criminal law literature. On the basis of a dogmatic study of them and a legal-logical analysis of their configuration, the purpose is also to explain the rationale behind the use of these sentences within the aforementioned legislations. And, thus, to propose ways of use and application of these penalties, both for the legislator and for the criminal adjudicator.
Educación, conocimiento e innovación
Authors: Casanova Cardiel Hugo , Trejo Quintana Janneth , Rodríguez Santiago Andrés , López Ramírez Mónica , Belausteguigoitia Rius María Isabel , Celis García Zaida María , de la Cruz Flores Gabriela , Cuevas Cajiga Yazmín Margarita , Plá Pérez Sebastián , Piña Osorio Juan Manuel , Pérez Castro Judith , González Ledesma Miguel Alejandro , Ruiz Velazco Sánchez Enrique
Published: June 2023

Con la llegada de la COVID-19, se implementaron diversas estrategias para dar continuidad a los procesos educativos. Sin embargo, estos esfuerzos para atender las necesidades formativas de la población no pudieron contener por completo los efectos negativos de la pandemia sobre la educación, por lo que los nuevos retos se sumaron a problemáticas que aquejan al campo educativo desde décadas atrás. Ante este escenario, el libro reúne a diez especialistas que analizan desde diversas perspectivas el hecho educativo mexicano durante la coyuntura que tuvo lugar entre 2020 y 2022. Las reflexiones que aquí se presentan, además de abordar diversos elementos y dimensiones de lo educativo, estudian al sistema mexicano en sus distintos niveles, desde el básico hasta el superior. Con ello, se busca enriquecer la discusión sobre cómo se afrontó la pandemia por COVID-19 en el campo educativo, de qué forma los principales actores educativos experimentaron sus consecuencias y sortearon sus desafíos, cómo se desarrolló la docencia en este contexto adverso, qué retos impuso la crisis sanitaria y qué escenarios y propuestas es posible visualizar.
Estudio del oportunismo en el canal de distribución desde la teoría de grupos de referencia: Un análisis empírico
Authors: Gimeno Arias Fernando
Published: June 2023

El presente trabajo de investigación tiene por objeto analizar el oportunismo en el canal de distribución mediante una de sus formas más peculiares: la participación en un mercado paralelo de un distribuidor del canal oficial. Para ello se recurre a la teoría sociológica de grupos de referencia con el objeto de explicar el oportunismo en el canal de distribución mediante la imitación de los miembros del grupo de referencia. Las hipótesis expuestas se contrastan con una muestra de distribuidores mayoristas españoles de productos de gran consumo, encontrando evidencias de que el efecto imitación del oportunismo puede graduarse en función de la posición jerárquica que ocupa el oportunista original dentro del grupo de referencia.
Importancia de las fuentes de conocimiento para la innovación: un análisis de las empresas de servicios en Colombia
Authors: Pertuz Vanessa , Ojeda Ramírez Mario Miguel
Published: June 2023

Este estudio analiza la importancia de las fuentes de conocimiento internas y externas (basadas en la ciencia, el mercado y la asistencia técnica) de acuerdo con la tipología de innovación de las empresas (innovadoras y potencialmente innovadoras). Para este propósito, se utilizaron datos de la Encuesta de Desarrollo e Innovación Tecnológica EDITS VII (2018-2019), una encuesta oficial que recopila información sobre la dinámica de innovación de las empresas del sector servicios en Colombia. Los datos fueron analizados mediante procedimientos de análisis multivariante conjunto, el cual realiza simultáneamente dos procesos de optimización: reducción de dimensionalidad y agrupación. Los resultados indican que las empresas innovadoras otorgan mayor importancia a las fuentes internas de conocimiento, en comparación con las potencialmente innovadoras. De forma similar, para las empresas innovadoras es más relevante el acceso a fuentes basadas en el mercado y en la asistencia técnica. Respecto a las fuentes científicas, solo se evidencia diferencias significativas en la importancia del conocimiento derivado de las universidades entre las tipologías de empresas analizadas. Finalmente, se encontró una relación inversa entre el carácter familiar y la importancia otorgada por las empresas a las fuentes de conocimientos internas y externas para innovar. Asimismo, las empresas que invierten en I+D y en formación otorgan una mayor importancia a las fuentes de conocimiento internas y externas para innovar.
Optimización del Net Promoter Score (NPS) con factores de expansión, una medición de experiencia de clientes en riesgo reputacional
Authors: Trejo García José Carlos , Soto Rosales Maria de Lourdes , Olivares Aguayo Héctor Alonso
Published: June 2023

Actualmente, la experiencia de consumo del cliente-usuario es analizada mediante encuestas de satisfacción, jugando un papel importante en la creación y/o mantenimiento del valor económico de una organización, así como medida del riesgo reputacional. Derivado de ello, surge el interés creciente por la medición del grado de satisfacción y lealtad. De esta manera, el objetivo de la presente investigación es proponer una alternativa y optimización para medir la satisfacción del cliente-usuario de una organización. El presente trabajo innova con proponer la integración de un factor de expansión mensual al cálculo ortodoxo del NPS, mismo que determina niveles de importancia para cada canal de atención; dicho factor considera el número de afluencia y las encuestas realizadas por canal. Así, los resultados arrojan una importante sobreestimación del cálculo convencional de aproximadamente 38% en comparación con el método propuesto, por lo que las organizaciones deben considerar elementos complementarios a la proporción de los promotores y detractores, tal es el caso de la relativa importancia de cada canal de atención ofrecida a los clientes.
Más allá de la venta online: de la calidad del servicio a la lealtad y boca a boca electrónicos
Authors: Acosta Morey Karla , Chávez Aguilar Andrea , Mauricio Andía Martín
Published: June 2023

El presente trabajo busca demostrar cómo la calidad del servicio es un antecedente, influyendo a través de la confianza y satisfacción, en la lealtad y el boca a boca electrónicos dentro de negocios de e-commerce. Se recopiló información de 300 usuarios con experiencia en compra electrónica y para comprobar las hipótesis propuestas se analizaron los resultados mediante el modelamiento de ecuaciones estructurales (SEM) con la técnica de mínimos cuadrados parciales (PLS). Los resultados mostraron que la calidad de servicio tiene un efecto positivo en la satisfacción y confianza electrónicas, y estás a su vez influyen en la lealtad y boca a boca. El principal aporte de esta investigación es ampliar el conocimiento en la relación entre la calidad de servicio y el boca a boca, en un entorno de e-commerce.
Identificación de factores sociales y económicos que influyen en el emprendimiento mediante un modelo de ecuaciones estructurales
Authors: Véliz Palomino José Carlos , Pimentel Bernal Paul Marcelo , Arana Barbier Pablo José
Published: June 2023

Esta investigación analiza la influencia que tienen los factores económicos y los factores sociales sobre el emprendimiento analizando la relación entre estos tres constructos, utilizando un modelo de ecuaciones estructurales (SEM) basado en PLS mediante un enfoque basado en la varianza, el cual analizó las relaciones entre estos factores y el emprendimiento con la disposición de los Objetivos de Desarrollo Sostenible, la Tasa de Intención Emprendedora y la Tasa Total de Actividad Empresarial en etapa inicial como variables latentes. Además, se recopilaron los datos de 60 países en diversas áreas geográficas, los cuáles se validaron por medio de un modelo cuantitativo de mínimos cuadrados parciales. Los resultados señalan que solo los factores económicos explican de manera significativa el emprendimiento, mientras que los factores sociales no son estadísticamente significativos en el modelo. Nuestros hallazgos implican que los países que invierten en consolidar sus factores económicos obtienen mayores índices de emprendimiento.
Representación y gestión de datos de pacientes mexicanos con COVID-19 mediante grafos de conocimiento
Authors: Bravo Maricela , González Darinel , Reyes-Ortiz José A. , Hoyos-Reyes Luis Fernando
Published: June 2023

En este artículo se presenta el desarrollo y evaluación de un grafo de conocimiento para la representación y gestión de datos de pacientes mexicanos que fueron registrados como casos positivos COVID-19. El empleo de grafos de conocimiento ofrece ventajas sobre otros modelos de representación, los grafos de conocimiento facilitan el acceso ágil a los datos mediante diversas tecnologías de consulta y acceso, lo que resulta relevante para la administración de sistemas de salud. Por otra parte, el empleo de grafos de conocimiento favorece la integración y expansión del conocimiento mediante la vinculación con otros grafos. En este trabajo se describe un enfoque de construcción que abarca desde el diseño del grafo general, la búsqueda y reutilización de grafos existentes, así como el registro de la información de pacientes COVID-19. Como resultado se obtuvo un modelo de grafo integral, eficiente y expandible; capaz de representar y extenderse incorporando información de otros grafos de conocimiento del dominio médico relacionados con los conceptos de la enfermedad del COVID-19, como son las vacunas, pruebas de laboratorio, los síntomas, medicamentos, así como como el diagnóstico clínico, lo que puede impactar en la mejora de la administración de sistemas de salud. El conjunto de datos utilizados durante las pruebas muestra la utilidad que tiene el grafo de conocimiento para registrar datos reales de pacientes mexicanos diagnosticados con COVID-19.
Análisis de estabilidad coalicional entre las aerolíneas mexicanas dentro del mercado de transporte aéreo de mercancías antes y durante la Covid-19
Authors: Larios Ferrer José Leonel , Vega-Ortiz Carlos , Redondo Galván Arturo
Published: June 2023

En este trabajo se analiza la estabilidad de coaliciones entre aerolíneas mexicanas dentro del mercado de transporte aéreo de mercancías (MTAM) antes y durante la Covid-19. Se aplica teoría de juegos y simulaciones en Scilab para determinar los elementos de cada juego. Se halla una diversidad de maneras que las aerolíneas tienen para formar parte de un grupo dominante en el MTAM, donde las aerolíneas pequeñas pueden tener relevancia. Además, se encuentra que la estabilidad de las alianzas depende de su solidez y que, en el largo plazo, no todas las coaliciones ganadoras minimales ofrecen estabilidad. Este tipo de estudios puede coadyuvar a la toma de decisiones por parte de las empresas dentro de dicho mercado y por parte del gobierno como agente regulador. Es importante saber las posibles alianzas para tener las ventajas que ello conlleva y llegar a nuevos puntos de carga en los actuales y futuros aeropuertos.
Comercio intraindustrial del sector manufacturero y de los subsectores de transporte y electrónicos entre México y los EUA
Authors: Mendoza Cota Jorge Eduardo
Published: June 2023

En este trabajo se analiza los determinantes del comercio intraindustrial del sector manufacturero, el subsector de electrónicos y computadoras y el subsector de equipo de transporte. Se utiliza un modelo ARDL para estimar los determinantes de largo y corto plazo. Los resultados indican que la evolución del comercio intraindustrial en el sector manufacturero entre México y los EUA, en el corto y largo plazo, es impactada positivamente por los salarios más bajos pagados en México y los flujos de IED hacia México, el impacto de la actividad económica de ambos países y el nivel de apertura comercial. Finalmente, el impacto de la caída económica ocasionada por la pandemia del Covid-19 tuvo un efecto en el comportamiento del comercio en el corto plazo.
Obesity in dogs: dimension of the problem and effects of feed
Authors: García Rendón Jorge , Pohls Ramírez Patricia
Published: June 2023

Obesity in dogs is a growing problem which affects between 30 – 60 % of the pet population world-wide. It is mainly caused by an energy consumption greater than the animal’s requirement; and needs to be detected and faced accordingly because it negatively affects their well-being and longevity. Some important observations are; although it has been reported that depends on the composition of the diet, that dogs fed 2 times a day have lower blood glucose levels, as well as insulin levels showing the same tendency as glucose. Ghrelin and GLP1 concentrations are no different feeding 1 or 2 times a day. Energy expenditure through physical activity is important as it increases the rate of energy utilization and helps to raise the metabolic rate, which contributes to a comprehensive weight reduction program. Metabolic Energy Rate (MER) in sterilized dogs is lower than for intact animals; therefore, sterilization of pets increases the risk of obesity.  The level of protein in the diet is important for promoting body protein synthesis and tissue repair. High protein diets work best when feed is offered ad libitum. Omega fatty acids reduce plasma concentrations of C-reactive protein and insulin. Dietary fiber helps to significantly reduce blood cholesterol and triglycerides.
Cambios ambientales en una laguna costera tropical: un enfoque de δ18O y δ13C en una especie residente
Authors: Carrillo-Birkhahn José Armando , Torres-Rojas Yassir Edén , Aguíñiga-García Sergio , Sánchez-González Alberto
Published: June 2023

Con la finalidad de estudiar las variaciones ambientales a nivel espacio-temporal en lagunas costeras tropicales y su impacto en fauna residente, se analizó la composición isotópica (δ18O y δ13C) de 70 otolitos (1 por par) pertenecientes al pez Bairdiella chrysoura, considerada especie residente del Área de Protección de Flora y Fauna Laguna de Términos (APFFLT). Se realizaron muestreos mensuales (septiembre de 2016 a agosto de 2017) en 17 estaciones del APFFLT, donde se obtuvieron los ejemplares a los cuales se les analizó el otolito “sagitta” mediante “GasBench” acoplado a un espectrómetro de masas de razones isotópicas. Se encontraron diferencias significativas en δ18O a nivel temporal, lo que sugiere que los otolitos responden a cambios ambientales, asociados a fluctuaciones de temperatura y salinidad relacionadas a la zona (bajo traslape entre temporadas en δ13C). Las ecuaciones de paleotemperatura mostraron un mejor ajuste con cambios de salinidad, lo que demuestra la influencia de la variable en lagunas costeras tropicales. En conclusión, el δ18O y δ13C mostraron que B. chrysoura registra cambios ambientales que se presentan en el APFFLT; sin embargo, se recomienda desarrollar ecuaciones paleoclimáticas para lagunas costeras tropicales para proyectar escenarios climáticos regionales.
Paronatrema guillerminae n. sp. (Trematoda: Syncoeliidae) parásito del tiburón azul Prionace glauca (Linnaeus) (Elasmobranchii: Carcharhinidae) en la costa occidental de Baja California Sur, México
Authors: Méndez Oscar
Published: June 2023

Se colectaron 9 especímenes de Paronatrema guillerminae n. sp. de las branquias del tiburón azul Prionace glauca (Linnaeus) durante la captura por pesca artesanal en la localidad de Punta Belcher (bahía Magdalena), Baja California Sur, México. Se propone a P. guillerminae n. sp. como una nueva especie dentro del género Paronatrema (Dollfus), por presentar características distintivas de otras especies cogenéricas, tales como el tamaño del cuerpo (más grande que las restantes), tegumento con extensiones en forma de escamas, forma del ovario (redondeado) y el número de testículos (más de 200 testículos). La nueva especie se describe en este trabajo.
Gorgojos (Coleoptera: Curculionidae) asociados con el cultivo de papa en Cusco, Perú
Authors: Yábar Erick , Jorge Melany
Published: June 2023

La papa es uno de los cultivos alimenticios más importantes para el Cusco, Perú. Sin embargo, es afectado por un gran número de plagas que pueden reducir grandemente su rendimiento. Entre los problemas más importantes se encuentran los “gorgojos” (Coleoptera: Curculionidae) que, a pesar de numerosos estudios, aún no han sido identificados adecuadamente. El presente proyecto de investigación se orientó a identificar las especies de gorgojos asociados con el cultivo de papa. Se estudió el material depositado en la Colección Entomológica de la Universidad Nacional de San Antonio Abad del Cusco. Se logró identificar a 20 especies, pertenecientes a las subfamilias Cryptorhynchinae: Maemactes vestitus Kirsch, 1875; Cyclominae: Adioristidius costulatus (Hustache, 1938), A. manu Morrone, 1994, Amathynetoides nitidiventris, Antarctobius sp., Falklandiopsis magellanica (Morrone, 1992), Hyperoides victus (Germain, 1896), Nacodius alectrus Morrrone, 1994, Puranius obrienorum Morrone, 1994 y Telurus sp.; y Entiminae: Cylydrorhinus villosulus (Hustache, 1926), C. elongatus (Kuschel, 1949), Cylydrorhinus sp., Amitrus mundus (Erichson, 1834), A. nitens Voss, 1947, Premnotrypes solaniperda (Kuschel, 1956), P. latithorax (Pierce, 1914), P. pusillus (Kuschel, 1956), Rhinotrypes grossepunctatus Kuschel, 1956 y R. laevigatus Kuschel, 1956.
Primer registro de Gibbesia neglecta (Crustacea: Stomatopoda) en aguas mexicanas del golfo de México con comentarios sobre su distribución batimétrica
Authors: Illescas-Monterroso Carlos M. , Hernández Carmen , Bortolini José Luis
Published: June 2023

Se revisaron los estomatópodos de la familia Squillidae recolectados entre 1973 y 2014 en aguas mexicanas del golfo de México y depositados en 3 colecciones carcinológicas de la Universidad Nacional Autónoma de México (UNAM). De 1,605 ejemplares identificados como Squilla empusa y recolectados en aguas de Tamaulipas, Veracruz y Tabasco, se identificó la presencia de 8 ejemplares de Gibbesia neglecta. Estos especímenes fueron capturados en 3 sitios, por arrastre con una red tipo camaronero en la plataforma continental de Tamaulipas, Tabasco y cerca de la laguna de Tamiahua, Veracruz, México; constituyen los primeros registros de esta especie en aguas mexicanas. El intervalo batimétrico de las capturas coincidió con lo registrado previamente y se confirma que el valor máximo de profundidad de la especie es, hasta ahora, en 64 m. Se analiza la distribución actual y se compara con la conocida para S. empusa.