bluuebunny/crossref_metadata_2025 huggingface dataset:
Maternal Thyroid Antibodies Associates With Cardiometabolic Risk Factors in Children at the Age of 16
Authors: Heikkinen Anna-Leena , Päkkilä Fanni , Hartikainen Anna-Liisa , Vääräsmäki Marja , Männistö Tuija , Suvanto Eila
Published: September 2017

Context and Objective

The objective of this study was to determine the effects of maternal thyroid dysfunction or antibodies during pregnancy on the cardiometabolic risk factors in children.

Design, Setting, and Participants

This prospective population-based cohort study, Northern Finland Birth Cohort 1986, included all pregnancies within a year in the area. Maternal serum samples were collected before the 20th week of gestation and analyzed for thyrotropin, free T4, thyroid-peroxidase antibodies (TPO-Abs), and thyroglobulin antibodies (Tg-Abs). Cardiometabolic risk factors in children at the age of 16 years were evaluated via blood sampling and clinical examination. Data were available for 3229 to 4176 mother–child pairs.

Main Outcome Measures

Waist circumference, blood pressure, lipids and lipoproteins, and insulin resistance were measured. Odds ratios (ORs) with 95% confidence intervals (CIs) of cardiometabolic risk factors in children with and without mothers with thyroid dysfunction or antibodies were calculated with logistic regression and adjusted for covariates.

Results

Children of TPO-Ab–positive mothers had higher odds of metabolic syndrome (OR, 2.57; 95%, CI 1.26 to 5.25) and waist circumference indicative of metabolic syndrome (OR, 1.69; 95% CI, 1.14 to 2.50). They were also more likely to be overweight or obese (OR, 1.56; 95% CI, 1.04 to 2.34). Maternal thyroid dysfunction or Tg-Ab positivity did not associate with cardiometabolic risk factors in children.

Conclusion

Metabolic syndrome, greater waist circumference, and higher body mass index were more prevalent in children of TPO-Ab–positive mothers, indicating an adverse cardiovascular health profile.
Changing Their Tune: How Consumers’ Adoption of Online Streaming Affects Music Consumption and Discovery
Authors: Datta Hannes , Knox George , Bronnenberg Bart J.
Published: September 2017

Instead of purchasing individual content, streaming adopters rent access to libraries from which they can consume content at no additional cost. In this paper, we study how the adoption of music streaming affects listening behavior. Using a unique panel data set of individual consumers’ listening histories across many digital music platforms, adoption of streaming leads to very large increases in the quantity and diversity of consumption in the first months after adoption. Although the effects attenuate over time, even after half a year, adopters play substantially more, and more diverse, music. Relative to music ownership, where experimentation is expensive, adoption of streaming increases new music discovery. While repeat listening to new music decreases, users’ best discoveries have higher play rates. We discuss the implications for consumers and producers of music.

Data and the online appendix are available at https://doi.org/10.1287/mksc.2017.1051 .
Optimal Rebate Strategies Under Dynamic Pricing
Authors: Hu Shanshan , Hu Xing , Ye Qing
Published: September 2017

Instant discounts and mail-in rebates are two common pricing tools in retail, but they are not simple substitutes. On the one hand, consumers discount the face value of a mail-in rebate, making it less effective than an instant discount in inducing consumers’ purchase. On the other hand, a portion of consumers with mail-in rebates fail to redeem them, resulting in savings for the retailer. We study how retailers, under pressure to move inventory, should use these two pricing tools to maximize revenue by determining the optimal use of mail-in rebates together with dynamic pricing of limited inventory. In a base model that allows frequent adjustment of product price and rebate face value, the optimal policy takes the form of “discount only,” “rebate only,” or a combination of the two. For useful heuristics with infrequent policy adjustment, we analyze the deterministic approximation of the base model. Interestingly, the deterministic solution splits the selling season into two segments, and it suggests using different pricing-rebate policies in each segment. Finally, we study a scenario in which the retailer has only one opportunity to introduce a static rebate, and we find that for any inventory level there is a cutoff time before which rebates should not be used. Our numerical studies show that such an optimal one-time static rebate policy performs well compared with the optimal revenue in the benchmark model.

The online appendix is available at https://doi.org/10.1287/opre.2017.1642 .
Experiential Learning, Competitive Selection, and Downside Risk: A New Perspective on Managerial Risk Taking
Authors: Jaspersen Johannes G. , Peter Richard
Published: September 2017

It is part of managerial wisdom that managers need to take risks in order to succeed. This is in stark contrast to the prominent agent-based theories of experiential learning and competitive selection that are known to be biased against risky alternatives in the long run. How can the positive managerial view on risk taking prevail given these results? Qualitative surveys of managers suggest risks to be acceptable if their outcome distribution meets certain criteria. We argue in this paper that these criteria are widely congruent with low downside risk. Using a novel simulation design, we analyze the effects of experiential learning and competitive selection on downside risk preferences in an ecology of agents. In the long run, experiential learning implies weak downside risk seeking, whereas competitive selection leads to strong downside risk aversion. Furthermore, competitive selection leads to the prevalence of outcome distributions with low downside risk in an ecology, even if they have a significantly higher level of total risk than comparable distributions with more downside risk. We draw implications for empirical studies on managerial behavior.

The online appendix is available at https://doi.org/10.1287/orsc.2017.1149 .
Exact Solutions for the Carrier–Vehicle Traveling Salesman Problem
Authors: Gambella Claudio , Lodi Andrea , Vigo Daniele
Published: September 2017

Carrier–vehicle systems generally consist of a slow carrier (e.g., a ship) with a long operational range and a faster vehicle (e.g., an aircraft) with a limited operational range. The carrier has the role of transporting the faster vehicle and of deploying, recovering, and servicing it. The goal of the carrier–vehicle traveling salesman problem (CVTSP) is to permit the faster vehicle to visit a given collection of targets in the shortest time while using the carrier as a base for possible multiple trips. As a consequence, the carrier and vehicle should be synchronized. The visiting sequence of the targets is not given a priori. We present a mixed-integer, second-order conic programming (MISOCP) formulation for the CVTSP. Computational results are shown for the resolution of the model with commercial solvers. The MISOCP structure and the relationship to the traveling salesman problem are exploited for developing a ranking-based solution algorithm that outperforms the commercial solvers.
Factors related to college students’ self-directed learning with technology
Authors: Sumuer Evren
Published: September 2017

This study investigated factors influencing college students’ self-directed learning with technology. A questionnaire was employed to obtain data from 153 college students on their self-directed learning readiness, the use of Web 2.0 tools for learning, online communication self-efficacy, and computer self-efficacy to predict their self-directed learning with technology. The data were analysed using sequential multiple regression and mediation analyses. The results showed that the predictor variables explained 19% of the variation in self-directed learning with technology. Self-directed learning readiness and the use of Web 2.0 tools for learning were found to be significant predictors of students’ self-directed learning with technology. Moreover, the results indicate that the use of Web 2.0 tools for learning significantly mediated the influence of students’ online communication self-efficacy and computer self-efficacy on their self-directed learning with technology. This study suggests that students be provided with scaffolding or assistance, not only for self-directed learning skills and the use of Web 2.0 tools for learning, but also for computer use and online communication in order to enhance their self-directed learning with technology.
Investment Of Temporarily Free Resources Of Czech Seniors – Present And Perspectives
Authors: Novotný Josef , Polách Jiří
Published: September 2017

The article deals with investment of Czech seniors into investment instruments. This article aims to find out how seniors invest in investment instruments in the Czech Republic and how much of their retirement they are willing to invest. The main problem that occurs in the investment environment in the Czech Republic is a reluctance to invest public investment. The result is the finding whether the seniors investors invest or not, including the introduction of new knowledge arising from research conducted at the chosen target group on the basis of the questionnaire survey. Investors in retirement are an important group of investors in terms of population, where their number is growing every year. The disadvantage of the elderly is often neglected investment company with regard to their age and income.
Electronic Banking, Its Use and Safety. Are There Differences in the Access of Bank Customers by Gender, Education and Age?
Authors: Belás Jaroslav , Korauš Michal , Gabčová Lenka
Published: September 2017

Electronic banking is an important area of banking activities, under which the commercial banks try to retain existing clients or attract new customers through a better quality of service and decrease in prices of these services. The aim of the article was to examine selected attributes of security and the use of electronic banking and quantify differences in approach of the bank customers by gender, education and age. Our research confirmed that the dominant part of banking customers use electronic access when managing their personal finances. We found out that there are some differences in the approach of the bank customers in terms of their education. The customers with higher education to a greater extent and more intensively use electronic banking. In the safety area, we did not find any significant differences between banking clients by gender, education and age. The only exception is the finding that clients up to 35 years are significantly more confident in the use of electronic banking through public networks.
Social Customer Relationship Management: A Case Study
Authors: Paliouras Konstantinos , Siakas Kerstin V.
Published: September 2017

Social Customer Relationships Management (CRM) is a current business trend providing new channels of two-way communication with customers through social media sites, such as Facebook, Twitter etc. Social CRM enables companies to interact in an easy and contemporary way directly with customers as well as to track customer interactions and their social influence. In this paper we examine the importance of CRM, e-CRM and Social CRM for businesses. We provide perspectives on objectives and types of CRM, the working cycle of CRM, the stages of a CRM Strategy and technology tools that are used in CRM. Social CRM is in particularly analyzed, since this new trend requires active engagement by customers and other stakeholders. The engagement process is essential to successful Social CRM and to successful social business practices. Finally, we describe experiences from three family businesses that introduced Social CRM as a result of a project carried out as an assignment in the ‘Social Media Networking’ module of the MSc course in ‘Web Intelligence’ at the Department of Informatics of Alexander Technological Educational Institute of Thessaloniki. The assignment of the groups was to create a Social CRM Strategy in collaboration with a company. This study is a follow-up of the outcome of the projects carried out in the autumn semester 2014 and 2015. The results show that all three companies consider that Social CRM is an excellent tool for obtaining real time valuable data about customers and a cheap way to reach them.
Asymmetries of Maximum Trunk, Hand, and Leg Strength in Comparison to Volleyball and Fitness Athletes
Authors: Mattes Klaus , Wollesen Bettina , Manzer Stefanie
Published: September 2017

Mattes, K, Wollesen, B, and Manzer, S. Asymmetries of maximum trunk, hand, and leg strength in comparison to volleyball and fitness athletes. J Strength Cond Res 32(1): 57–65, 2018—Playing volleyball and corresponding training loads lead to specific strains and might result in asymmetric muscle pattern. The study aimed to identify volleyball-specific maximum bilateral strength asymmetries in comparison to fitness athletes. The cross-sectional study design compared an age-matched male volleyball group (n = 23; 27.9 ± 5 years) with a fitness group (n = 30; 26.3 ± 3 years). The participants performed an isometric maximum handgrip strength test followed by 2 isokinetic concentric maximum strength tests to determine the performance capacity of the axial trunk rotators (left-right) and bilateral leg extensors. Differences between groups and left-right side (within group) were proven by variance analysis with repeated measurements. There was a left-right difference with higher maximum forces for the rotation in the right direction in the volleyball group (p = 0.0058) but the group interaction effect was not significant after alpha error accumulation. The results of the leg press indicated a stronger left leg in the fitness group (nonsignificant) in comparison to the volleyball group. Overall, the volleyball group displayed symmetry in maximum handgrip and leg strength and asymmetry in trunk rotation with higher strength in right rotation. This asymmetry for the right trunk rotation showed a small effect size. The resulting asymmetry might be an adaptation to the volleyball techniques, but it remains unclear if this is a cause for or of injury. As a practical implication, the asymmetries should be examined to develop individualized strength training programs for both groups.
Comparative Effects of Two Interval Shuttle-Run Training Modes on Physiological and Performance Adaptations in Female Professional Futsal Players
Authors: Teixeira Anderson S. , Arins Francimara B. , De Lucas Ricardo D. , Carminatti Lorival J. , Dittrich Naiandra , Nakamura Fábio Yuzo , Guglielmo Luiz Guilherme A.
Published: September 2017

Teixeira, AS, Arins, FB, De Lucas, RD, Carminatti, LJ, Dittrich, N, Nakamura, FY, and Guglielmo, LGA. Comparative effects of two interval shuttle-run training modes on physiological and performance adaptations in female professional futsal players. J Strength Cond Res 33(5): 1416–1428, 2019—The purpose of this study was to analyze the effects of 2 shuttle-run interval training (SRIT) models with 1 and 3 directional changes per running bout on the aerobic and anaerobic performances of elite female futsal players. Sixteen players competing in the Brazilian National Division League took part in the study. The training protocols consisted of shuttle-run intervals organized in 4 sets of 4-minute bouts with 3 minutes of rest intervals between the sets. The SRIT models were composed of 1 (7.5 seconds running and 7.5 seconds pause [SRIT7.5×7.5]; n = 7) or 3 (15 seconds running and 15 seconds pause [SRIT15×15]; n = 9) directional changes. The athletes performed the following tests before and after a 5-week training period: incremental treadmill test (ITT), futsal intermittent endurance test (FIET) (with respective peak speeds [PSs]), and a repeated sprint ability (RSA) test. After the training period, PSFIET and speed at the second lactate turnpoint were very likely and almost certainly increased in both training regimens, respectively. SRIT15×15 induced possibly greater improvements in PSITT (+3.28%, 90% CL −0.16 to 6.82) and RSAmean (+1.17%, 90% CL −0.68 to 3.05) than SRIT7.5×7.5. In addition, SRIT15×15 resulted in a likely greater improvement in running economy (+4.33%, 90% CL −0.35 to 9.23) compared with SRIT7.5×7.5. In elite female futsal players, SRIT15×15 is a promising strategy to enhance performance-related physical fitness attributes in a short-term period (5 weeks) during the preseason, Because of its superior effects on these important aerobic and anaerobic qualities than a protocol with fewer directional changes.
Determination of Vertical Jump as a Measure of Neuromuscular Readiness and Fatigue
Authors: Watkins Casey M. , Barillas Saldiam R. , Wong Megan A. , Archer David C. , Dobbs Ian J. , Lockie Robert G. , Coburn Jared W. , Tran Tai T. , Brown Lee E.
Published: September 2017

Watkins, CM, Barillas, SR, Wong, MA, Archer, DC, Dobbs, IJ, Lockie, RG, Coburn, JW, Tran, TT, and Brown, LE. Determination of vertical jump as a measure of neuromuscular readiness and fatigue. J Strength Cond Res 31(12): 3305–3310, 2017—Coaches closely monitor training loads and periodize sessions throughout the season to create optimal adaptations at the proper time. However, only monitoring training loads ignores the innate physiological stress each athlete feels individually. Vertical jump (VJ) is widely used as a measure of lower-body power, and has been used in postmatch studies to demonstrate fatigue levels. However, no pretraining monitoring by VJ performance has been previously studied. Therefore, the purpose of this study was to determine the sensitivity of VJ as a measure of readiness and fatigue on a daily sessional basis. Ten healthy resistance-trained males (mass = 91.60 ± 13.24 kg; height = 179.70 ± 9.23 cm; age = 25.40 ± 1.51 years) and 7 females (mass = 65.36 ± 12.29 kg; height = 162.36 ± 5.75 cm; age = 25.00 ± 2.71 years) volunteered to participate. Vertical jump and BRUNEL Mood Assessment (BAM) were measured 4 times: pre-workout 1, post-workout 1, pre-workout 2, and post-workout 2. Workout intensity was identical for both workouts, consisting of 4 sets of 5 repetitions for hang cleans, and 4 sets of 6 repetitions for push presses at 85% 1 repetition maximum (1RM), followed by 4 sets to failure of back squats (BSs), Romanian deadlift, and leg press at 80% 1RM. The major finding was that VJ height decrement (−8.05 ± 9.65 cm) at pre-workout 2 was correlated (r = 0.648) with BS volume decrement (−27.56 ± 24.56%) between workouts. This is important for coaches to proactively understand the current fatigue levels of their athletes and their readiness to resistance training.
Concurrent Training Followed by Detraining: Does the Resistance Training Intensity Matter?
Authors: Sousa António C. , Marinho Daniel A. , Gil Maria H. , Izquierdo Mikel , Rodríguez-Rosell David , Neiva Henrique P. , Marques Mário C.
Published: September 2017

Sousa, AC, Marinho, DA, Gil, MH, Izquierdo, M, Rodríguez-Rosell, D, Neiva, HP, and Marques, MC. Concurrent training followed by detraining: does the resistance training intensity matter? J Strength Cond Res 32(3): 632–642, 2018—The aim of this study was to analyze the training and detraining (DT) effects of concurrent aerobic training and resistance training against 3 different external loads on strength and aerobic variables. Thirty-two men were randomly assigned to 4 groups: low-load (LLG, n = 9), moderate-load (MLG, n = 9), high-load (HLG, n = 8), and control group (CG, n = 6). Resistance training consisted of full squat (FS) with a low load (40–55% 1 repetition maximum [1RM]), a moderate load (55–70% 1RM), or a high load (70–85% 1RM) combined with jump and sprint exercises. Aerobic training was performed at 75% of the maximal aerobic speed for 15–20 minutes. The training period lasted for 8-week, followed by 4-week DT. Pretraining, post-training, and post-DT evaluations included 20-m running sprints (0–10 m: T10; 0–20 m: T20), shuttle run test, countermovement vertical jump (CMJ) test, and loading test (1RM) in FS. All the experimental groups showed improvements (p ≤ 0.05) in all the parameters assessed, except the LLG for T10 and the HLG for T20. The LLG, MLG, and HLG showed great changes in 1RM and V̇o
2max compared with the CG (p ≤ 0.05), whereas the HLG and MLG showed a greater percentage change than the CG in T10 (p < 0.001) and CMJ (p ≤ 0.05). The 4-week DT period resulted in detrimental effects in all variables analyzed for all 3 experimental groups. In conclusion, our results suggest that strength training programs with low, moderate, or high external loads combined with low-intensity aerobic training could be effective for producing significant gains in strength and aerobic capacities. Moreover, the higher loads used increased gains in explosive efforts.
Biogeochemical characterization of municipal compost to support urban agriculture and limit childhood lead exposure from resuspended urban soils
Authors: Fitzstevens Maia G. , Sharp Rosalie M. , Brabander Daniel J.
Published: September 2017

Chronic low-level lead exposure among low-income minority children is an urgent environmental justice issue. Addressing this ubiquitous urban public health crisis requires a new transdisciplinary paradigm. The primary goals of this work are to inform best practices for urban gardeners working in lead contaminated soils and to reimagine urban organic waste management schemes to produce compost, which when covering or mixed with urban soil, could minimize lead exposure. We investigate bulk and bioaccessible lead from five types of compost used in urban gardens in Boston, MA. We categorized them by feedstock and measured bulk elemental concentrations and physical characteristics. Our results show that different feedstocks exhibit unique geochemical fingerprints. While bulk lead concentrations in compost are a fraction of what is typical for urban soils, the bioaccessible lead fraction in compost is greater than the default parameters for the Integrated Exposure Uptake Biokinetic (IEUBK) model. The lack of geochemical differences across feedstocks for lead sorption to carbon indicates a similar sorption mechanism for all compost. This suggests that municipal compost would be suitable for capping lead contaminated urban soils. Risk assessment models should consider lead bioaccessibility, to prevent the underprediction of exposure risk, and should include compost along with soils as urban matrices. Based on the observed bioaccessibility in our compost samples, 170 mg/kg total lead in compost will yield the same bioaccessible lead as the IEUBK model predicts for the 400 mg/kg EPA soil lead benchmark. Local logistical challenges remain for interdisciplinary teams of city planners, exposure scientists, and urban agricultural communities to design organic waste collection practices to produce compost that will support urban agriculture and primary lead exposure prevention.
Exile, Within and Without: New Work in Two Modes from Rithy Panh
Authors: Boyle Deirdre
Published: September 2017

Franco-Cambodian filmmaker Rithy Panh has two new works titled Exil (Exile). His 2016 poetic film is a sepia-toned meditation on time, memory, revolution, and resistance that materializes dreams, fantasies, and nightmares with the mundane realities of his childhood survival of genocide. This survival is juxtaposed with a complex, disembodied narration on being-in-exile. Inspired by this original film, Panh's 2017 immersive multimedia installation embraces the current global refugee crisis, combining photographs, archival film footage, selected objects, and an audio track all designed to elicit understanding and compassion for people fleeing war, oppression, and catastrophe. Both film and installation are intellectually rigorous and aesthetically compelling, and both share visual motifs, but each stakes out a different perspective—the former offers an introspective vision of one man's experience of exile while the latter documents the plight of millions of stateless people. Together they represent the latest achievements of a major artist who is driven to remember and to affirm his own humanity and the humanity of Others.
Stress and sex: does cortisol mediate sex change in fish?
Authors: Goikoetxea Alexander , Todd Erica V , Gemmell Neil J
Published: September 2017

Cortisol is the main glucocorticoid (GC) in fish and the hormone most directly associated with stress. Recent research suggests that this hormone may act as a key factor linking social environmental stimuli and the onset of sex change by initiating a shift in steroidogenesis from estrogens to androgens. For many teleost fish, sex change occurs as a usual part of the life cycle. Changing sex is known to enhance the lifetime reproductive success of these fish and the modifications involved (behavioral, gonadal and morphological) are well studied. However, the exact mechanism behind the transduction of the environmental signals into the molecular cascade that underlies this singular process remains largely unknown. We here synthesize current knowledge regarding the role of cortisol in teleost sex change with a focus on two well-described transformations: temperature-induced masculinization and socially regulated sex change. Three non-mutually exclusive pathways are considered when describing the potential role of cortisol in mediating teleost sex change: cross-talk between GC and androgen pathways, inhibition of aromatase expression and upregulation ofamh(the gene encoding anti-Müllerian hormone). We anticipate that understanding the role of cortisol in the initial stages of sex change will further improve our understanding of sex determination and differentiation across vertebrates, and may lead to new tools to control fish sex ratios in aquaculture.
Therapeutic benefits of phosphodiesterase-5 inhibition in chronic heart failure: A meta-analysis
Authors: Vecchis Renato De , Cesaro Arturo , Ariano Carmelina
Published: September 2017

Background

Phosphodiesterase-5 inhibitors (PDE5i) have been shown to be beneficial for patients with pulmonary arterial hypertension. However, several studies would have documented a useful effect of PDE5i even for pulmonary hypertension secondary to left-sided chronic heart failure (CHF).

Methods

We performed a meta-analysis including randomized controlled trials (RCTs) which had compared PDE5i (mostly sildenafil) and placebo in CHF patients.

Results

Fourteen studies enrolling a total of 928 patients were incorporated in the meta-analysis. In heart failure with reduced left ventricular ejection fraction (HFREF), PDE5i, compared to placebo, significantly improved the composite of death and hospitalization (OR = 0.28; 95% CI: 0.10–0.74). They also improved peak VO2 [difference in means (MD): 3.76; 95% CI: 3.27–4.25], six-minute walking distance test (MD: 22.7 m; 95% CI: 8.19–37.21), and pulmonary arterial systolic pressure (MD: −11.52 mmHg; 95% CI: −15.56 to −7.49). Conversely, in CHF with preserved left ventricular ejection fraction (HFpEF), PDE5i proved not to yield any significant improvement of the investigated outcomes.

Conclusions

In HFREF, PDE5i showed beneficial effects on the composite of death and hospitalization, as well as on exercise capacity and pulmonary hemodynamics. Conversely, in HFpEF, no significant clinical, spiroergometric, or hemodynamic improvement was achieved using PDE5i therapy.
Epidemiology and antibiotic resistance phenotypes of diarrheagenic Escherichia coli responsible for infantile gastroenteritis in Ouagadougou, Burkina Faso
Authors: Konaté Ali , Dembélé René , Guessennd Nathalie K. , Kouadio Fernique Konan , Kouadio Innocent Kouamé , Ouattara Mohamed Baguy , Kaboré Wendpoulomdé A. D. , Kagambèga Assèta , Cissé Haoua , Ibrahim Hadiza Bawa , Bagré Touwendsida Serge , Traoré Alfred S. , Barro Nicolas
Published: September 2017

The emergence and persistence of multidrug-resistant (MDR) diarrheagenic Escherichia coli (DEC) causing acute diarrhea is a major public health challenge in developing countries. The aim of this study was to evaluate the resistance phenotypes of DEC isolated from stool samples collected from children less than 5 years of age with acute diarrhea living in Ouagadougou/Burkina Faso. From August 2013 to October 2015, this study was carried out on 31 DEC strains of our study conducted in “Centre Médical avec Antenne Chirurgicale (CMA)” Paul VI and CMA of Schiphra. DEC were isolated and identified by standard microbiological methods and polymerase chain reaction (PCR) method was used to further characterize them. Antimicrobial susceptibility testing was done based on the disk diffusion method. DEC isolates were high resistant to tetracycline (83.9%), amoxicillin (77.4%), amoxicillin clavulanic acid (77.4%), piperacillin (64.5%), and colistin sulfate (61.3%). The most resistant phenotype represented was the extended spectrum β-lactamase (ESBL) phenotype (67.7%). Aminoglycosides were 100% active on enteroinvasive E. coli (EIEC) and enterohemorrhagic E. coli (EHEC). All the DEC isolates exhibited absolute (100%) sensitivity to ciprofloxacin. Monitoring and studying the resistance profile of DEC to antibiotics are necessary to guide probabilistic antibiotic therapy, especially in pediatric patients.
Multidrug-resistant Pseudomonas aeruginosa induce systemic pro-inflammatory immune responses in colonized mice
Authors: von Klitzing Eliane , Bereswill Stefan , Heimesaat Markus M.
Published: September 2017

The World Health Organization has rated multidrug-resistant (MDR) Pseudomonas aeruginosa as a critical threat to human health. In the present study, we performed a survey of intestinal colonization, and local and systemic immune responses following peroral association of secondary abiotic mice with either a clinical MDR P. aeruginosa or a commensal murine Escherichia coli isolate. Depletion of the intestinal microbiota following antibiotic treatment facilitated stable intestinal colonization of both P. aeruginosa and E. coli that were neither associated with relevant clinical nor histopathological sequelae. Either stable bacterial colonization, however, resulted in distinct innate and adaptive immune cell responses in the intestines, whereas a pronounced increase in macrophages and monocytes could be observed in the small as well as large intestines upon P. aeruginosa challenge only, which also applied to colonic T lymphocytes. In addition, TNF secretion was exclusively elevated in large intestines of P. aeruginosa-colonized mice. Strikingly, association of secondary abiotic mice with MDR P. aeruginosa, but not commensal E. coli, resulted in pronounced systemic pro-inflammatory responses, whereas anti-inflammatory responses were dampened. Hence, intestinal carriage of MDR P. aeruginosa as compared to a mere commensal Gram-negative strain in otherwise healthy individuals results in distinct local and systemic pro-inflammatory sequelae.
Expected long-term labour market resilience and the European Union’s perceived role — results of an online Policy Delphi
Authors: Lengyel György , Göncz Borbála , Tóth Lilla
Published: September 2017

The 2008 crisis highlighted how fragile the labour markets of the European Union’s member states were, while it also directed attention to the eventual further deepening of integration as a potential solution. Nevertheless, employment and labour market policy competences are still on the national level with relatively low EU intervention. In a recent study, we explored the role of the EU in facilitating potential policy solutions with regards to labour market resilience until 2030. The study focused on labour market experts’ opinion, coming from different European countries; and took form of an online Policy Delphi Survey combined with backcasting to predict the importance and feasibility of policies concerning future challenges. The most important policies considered to be best suited to deal with the main challenges of the labour market in the EU until 2030 are education, investment in human and social capital and improvement of social policies and protection, including migration policy. The research revealed a systematic gap between the importance and feasibility of relevant solutions.
Is discrepancy between confidence and spending driven by pessimism or by high aspriations? — Review of the discrepancy between the admitted financial situation and actual spending in Hungary
Authors: Hajdu Csongor
Published: September 2017

The opinions of people are expected to forecast their actions, and even major economic institutions rely on this correlation. This research paper examines a case when the opinion of people about their financial situation contradicts their financial-related actions. In 2012 in Hungary the general opinion of people about their financial situation was showing the lowest confidence in the world, with a significant declining trend, reaching an extremely low level. Although the general expectation would be that this pessimism triggers a set-back in consumer spending, figures show that Hungarians were on the other end of the scale regarding their expenditures and were greatly increasing their spending. This raises the question: why do people say they are in such a tough financial situation yet instead of saving they increase their spending? This paper presents a cross-country analysis that reviews the severity of this discrepancy, as well as proves the validity of the question by excluding several alternative explanations, followed by a recommendation and hypotheses for a detailed research to explain the phenomenon.
Ocupar, resistir e a luta nas redes sociais.
Authors: Carneiro Silvio
Published: September 2017

Ensaio sobre a articulação entre o movimento de ocupações e as comunicações virtuais da página de Facebook "Escola de Luta Fernão Dias Paes".
Web crippling of stainless-steel tubes with bolt-anchored carbon-fibre-reinforced polymer
Authors: Zhou Feng , Luo Chenhao , Ling Yunhao
Published: September 2017

This paper presents a numerical investigation and design equation for web crippling of cold-formed stainless-steel tubes strengthened with bonded and bolt-anchored plates of carbon-fibre-reinforced polymer. The bolt-anchored polymer strengthening scheme was proved by previous experimental study to delay or totally prevent de-bonding failure and significantly improve web-crippling behaviour of stainless-steel tubes. A non-linear finite-element model was developed and verified against existing experimental results. An extensive parametric study was then carried out using different web slenderness, bearing-plate length and polymer-plate thickness to investigate the increased resistance of strengthened stainless-steel tubes to web crippling. Two loading conditions of end two-flange loading and interior two-flange loading were considered. The test data and numerical results were then compared with US and European web-crippling design rules for stainless-steel structures. A comparison was also made with a web-crippling design equation proposed by other researchers for polymer-strengthened stainless-steel tubes. Finally, a unified web-crippling equation is proposed for bolt-anchored polymer-strengthened cold-formed stainless-steel tubes under end and interior two-flange loading conditions.
Um revolucionário amoroso, tolerante, bem humorado e radicalmente democrático: saudades de Paulo Freire. Uma entrevista com a professora Lisete Arelaro
Authors: Saul Alexandre , Pitano Sandro De Castro
Published: September 2017

Entrevista com a professora e pesquisadora Lisete Regina Gomes Arelaro, por Sandro de Castro Pitano e Alexandre Saul.
Ler para ser: a leitura na perspectiva freiriana
Authors: Lacerda Junior José Calvalcante , Gasparetto Higuchi Maria Inês
Published: September 2017

O texto apresenta uma reflexão sobre a leitura à luz da concepção de Paulo Freire, que a infere como prática social capaz de levar o sujeito a compreender os intercursos ideológicos da realidade. Nesse sentido, o mesmo objetiva compreender a importância da leitura tendo como parâmetro a perspectiva de Paulo Freire. Para tanto, sua construção metodológica pautou-se em uma pesquisa bibliográfica, a qual investigou o campo teórico-conceitual da leitura, trançando uma reflexão a partir de Freire (1987; 1996; 2001; 2003). Desse modo, como resultado, a interface entre leitura e o pensamento freireano sinaliza a necessidade de explicitar o ato de ler como via de construção de uma consciência individual e coletiva acerca das tramas que atravessam a realidade. Assim, a intenção proposta é propiciar a consideração imprescindível da leitura na construção de um ser humano crítico e instrumentalizado para transformação ideológica da sociedade.
High-fidelity detection of IFN-? secreting CD4 and CD8 cells in response to soluble or Ad5 transduced influenza antigens using ELISPOT and cell sorting v1
Authors: Pichugin Aleksey , Bagaev Alexander , Ataullakhanov Ravshan
Published: September 2017

ELISPOT allows detection of single IFN-γ-secreting cell, but the use of unseparated spleen cells removes the advantages of the method due to a high back ground of IFN-γ-production and uncertainty of the phenotype of secreting cells (CD4, CD8 or NK). We used high purity sorted CD4 and CD8 cells. For in vitro restimulation of CD8 T-cells, we used dendritic cells that present antigenic epitopes of M2, NP or of adenovirus in the context of MHC class I. In this instance, dendritic cells were transduced with Ad5-tet-M2, Ad5-tet-NP or Ad5-null, respectively. For restimulation of CD4 T-cells in vitro, we used dendritic cells that present antigenicM2 or NP epitopes in the context of MHC class II. For this purpose, dendritic cells were additionally activated by lipopolysaccharide E. coli (1 μg/ml) and were loaded with recombinant protein NP or M2e peptide..
Peripheral Blood Mononuclear Cells (PBMC) and plasma isolation from whole peripheral blood v1
Authors: L. Dembinski Jennifer , Savic Miloje
Published: September 2017

This protocol describes isolation of PBMC from human whole peripheral blood samples by density gradient centrifugation, using One SepMate-50ml tube (https://www.stemcell.com/sepmate-trade-hassle-free-pbmcs-in-just-15-minutes.html), followed by freeze and thaw protocol.
Jueces de ejecución de penas, subrogados penales y hacinamiento carcelario
Authors: Serrano Juan Sebastián , Pinzón Manuel , Guío Armando
Published: September 2017

This paper presents the results obtained in a field work carried out in the year 2013, in which it was tried to study the role of the execution judges of penalties within the problematic of prison overcrowding. Fieldwork included different research methods, such as collection of documentation, analysis of court decisions and interviews with judges. The purpose was to identify the legal and social patterns that influence the decision-making of judges of execution of penalties to apply criminal surrogates. Identifying these aspects of sentencing judges is relevant to the debate over prison overcrowding, bearing in mind that these are the ones who ultimately decide on the application of alternative measures to the prison.
The faces of religiosity in Poland
Authors: Śliwak Jacek , Wiechetek Michał , Zarzycka Beata , Bartczuk Rafał P.
Published: September 2017

The phenomenon of religiosity is increasingly often explored by representatives of various scientific disciplines. This is particularly noticeable in the field of the psychology of religion. The issues of human religiosity have been attracting an increasing amount of interest among Polish scholars. The present article presents the main trends illustrating the development of interest in the phenomenon of religiosity in the field of psychology. Both Polish and international contexts are consid-ered. Additionally, the papers included in the special issue of Roczniki Psychologiczne (Annals of Psychology) are outlined. The special issue is devoted to the problems addressed by Polish psychologists interested in the phenomenon of human religiosity.
Wiara lub niewiara polskich naukowców w Boga a ich poglądy na relację między nauką a religią
Authors: Gołąb Andrzej
Published: September 2017

The paper presents selected results of a study on the religious views of 279 Polish scholars with a doctoral or higher degree. The percentage of scholars who declared belief in God was 56.3%. The four groups with the highest indices were chemists (80%), geographers and Earth scientists (76.2%), mathematicians and information technology specialists (73.1%), and medical scientists (64.5%). A small proportion of respondents (6.5%) chose the following option: “I don’t believe in a personal God but I believe in a higher power of some kind.” The percentages of atheists and agnostics were 18.3% and 7.2%, respectively. The subjects’ views on the relationship between science and religion were categorized according to the Barbour’s typology (Barbour, 1990). The largest proportion of the subjects (41.9%) denied the inevitability of conflict between science and religion; 13% held the opposite view. Some scholars (19.6%) expressed the view that science and religion should be treated as independent areas of inquiry. The relationship of dialog seemed to be the best form of their coexistence to 2% respondents, while 3.6% were in favor of the cooperation of science and religion in building a comprehensive worldview.
Wstępna charakterystyka psychometryczna polskiej wersji kwestionariusza Religious Commitment Inventory-10 (RCI-10-PL) Everetta Worthingtona i współpracowników
Authors: Polak Jarosław , Grabowski Damian
Published: September 2017

The article presents the theoretical background and the psychometric properties of the Polish version of the Religious Commitment Inventory-10 (RCI-10-PL). Confirmatory factor analysis (CFA) was conducted on two samples: 273 participants (Sample A) and 308 participants (Sample B). The results of the CFA showed an acceptable fit of empirical data to the one-factor and two-factor theoretical models, the latter model having a slightly better fit. Moreover, we obtained satisfactory values of the reliability coefficient. Cronbach alpha coefficients for the Polish version of the RCI scales ranged from .82 to .95. Test-retest reliability correlations ranged from .90 to .91 for a five- -week interval between ratings. We also found positive correlations between specific dimensions of RCI-10-PL and religious attitudes, ethical sensibility, and focus on the achievement of harmony in life, which confirms the external validity of the instrument. The results of the analysis conducted on Polish samples are similar to the results obtained from American samples.
O absenteísmo na equipe de enfermagem em um hospital no interior de Minas Gerais
Authors: Moura Josely Pinto de , Silva Policardo Gonçalves da , Miranda Jemima Alves , Oliveira Márcia Mattes Mello de
Published: September 2017

Levantar o índice do absenteísmo da equipe de enfermagem e suas principais causas em um hospital no interior de Minas Gerais. Trata­-se de uma pesquisa quantitativa, descritiva, retrospectiva com análise documental. A pesquisa teve como público alvo todos os funcionários lotados nas unidades de internação do referido hospital. Foram totalizados 408 funcionários de enfermagem, sendo eles, auxiliares de enfermagem, técnicos de enfermagem e enfermeiros. Utilizou os arquivos do setor de Recursos Humanos (RH) como fonte da coleta de dados. Foram identificados 2308 afastamentos de profissionais de enfermagem no ano em estudo, sendo 298 faltas por motivo não justificado e 2010 faltas justificadas por atestados médicos. As unidades com maiores taxas de absenteísmo foram: Ala A (2,76%), Ala F (2,50%), UTI Neonatal (2,30%), Clínica Cirúrgica (2,12%), Pediatria e UTI Adulto (1,96%). As principais causas de absenteísmo por doenças mais frequentes, foram: diarreia (55 atestados), dor lombar (25 atestados), sinusite (20 atestados) e episódios depressivos (15 atestados). Os setores que obtiveram maior índice foram aqueles que apresentaram uma rotina mais complexa de cuidados intensivos. Os setores que obtiveram maior índice de absenteísmo são a Ala A (2,76%) e a Ala F (2,50%). As principais causas dos atestados médicos que contribuíram para o absenteísmo, foram: diarreia (55 atestados) e dor lombar (25 atestados).
Prevalência de Silicose Entre Trabalhadores de Alpinópolis, Guapé e São José da Barra
Authors: Costa Jaqueline Campos
Published: September 2017

A silicose é uma doença pulmonar ocupacional que está relacionada com a geografia do local de trabalho, ocasionada através da inalação de poeira ou substâncias químicas. A evolução começa a partir do período de exposição, mas em fases iniciais é assintomática, com possíveis reações agudas ou crônicas. De acordo com o período de duração e intensidade da exposição, pode ocorrer um quadro clínico de dispnéia. O objetivo foi identificar e classificar os pacientes com silicose no Centro de Referência Regional em Saúde ao Trabalhador (CEREST), destacando os municípios de Alpinópolis, Guapé e São José da Barra. Foram analisados prontuários do mês de janeiro de 2008 a julho de 2016, para posterior classificação quanto a gênero, faixa etária e profissão. Com base nos dados obtidos, constatou-se que há predominância do gênero masculino, devido ao trabalho braçal. Avaliou-se que Alpinópolis apresenta mais casos pelo fato da cidade possuir área geográfica composta por montanhas de arenito quartzito. Na análise da faixa etária obteve-se índices elevados para idade, de 30 a 39 anos, justificado pela intensidade de exposição. Em relação a atividade empregatícia, funções de extrator e serrador apresentam mais adoecimentos por maior liberação da poeira durante a extração e os processos iniciais. Conclui-se que é indispensável a utilização dos EPI’s pelos trabalhadores, e que a capacitação e informação dos profissionais da área da saúde e segurança é fundamental para minimizar a prevalência desses índices, além da promoção de campanhas, disponibilização de cursos e palestras que visem a prevenção da doença.
La función probatoria del documento público y privado en los tipos penales de falsedad documental
Authors: Medina Rico Ricardo Hernán , Acosta Zarate Laura
Published: September 2017

El presente texto busca abordar la existencia del documento como medio probatorio y las implicaciones jurídico penales de plasmar falsedades en los mismos a partir de un análisis de fuentes del derecho tales como la jurisprudencia y la doctrina y una revisión normativa bajo un estudio de la veracidad y la autenticidad como principios fundantes de la importancia del escrito. A partir de ello se presenta la definición de este medio probatorio en el sistema normativo vigente y cuáles son los elementos del mismo así como la distinción entre uno de carácter privado y aquel proferido por una entidad estatal. También se realiza un análisis sobre la mendacidad y el artificio - ya sea en la veracidad o en la autenticidad - del documento y se resolverá a la cuestión de si cualquier tipo de alteración a la verdad conlleva a la comisión de algún tipo de punible o si por el contrario existirán circunstancias que no sean del tenor de la justicia penal colombiana. Lo anterior permite concluir, al finalizar el texto, que no todo engaño plasmado en un papel conlleva a un delito de falsedad pero en el evento de existir una falta sobre la verdad, ya sea material o ideológica, y este documento tenga relevancia en el tráfico común de las cosas, implicará las sanciones previstas en el Código Penal Colombiano.