bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of the Factors Affecting the Level of Tourist Visits at Puncak Bila Tourism Park
Authors: Mahmud Amir
Published: July 2023

This study aims to test and analyze the effect of retribution, cost and distance on the number of tourist visits of Puncak Bila tourist park in Sidenreng Rappang Regency. The population in this study was in Sidrap district, and the sampling  method used the accindental sampling method, namely random sampling.   This study used primary data by providing questionnaires to respodents or peak travelers when. The analysis method in this study uses multiple linear regression analysis with the analysis tool used is SPSS-23.  The results showed that in the hypothesis test, the calculated value on all variables was greater than the ttabel, namely Retribution (X1) 6.665; Cost (X2) 3,365; The distance (X3) is 6.696 > 1.98498 with a significant value below 0.05 so that H0 is received which means that levy, cost, and distance are factors that affect the number of tourist visits in Puncak Tourism Park Bila Sidenreng Rappang Regency.
Improving Brand Image of Television Electronic Products Through Integrated Marketing Communications
Authors: Latief Fitriani
Published: July 2023

This study aims to examine and analyze the effect of integrated marketing communications (advertising, sales promotion, public relations, personal selling, direct & online marketing) on ​​the brand image of electronic television products. The population in this study were 2,576 customers or users of the 2018 Panasonic brand television. To determine the number of samples, the Slovin formula was used and 100 people were obtained spread across the city of Makassar. The data in this study used primary data collected by distributing questionnaires to all respondents. The data in this study will be tested with several stages of testing, namely descriptive statistical tests, validity and reliability tests and testing of all hypotheses through the coefficient of determination test, partial test (t test) and simultaneous test (f test). The results of this study indicate that the variables of advertising, promotion, public relations, personal selling and direct & online marketing have a positive and significant effect on the brand image of television electronic products at PT. Panasonic Goblet. And based on the test results on all variables in the integrated marketing communication program, the promotion variable has the most dominant value influencing the brand image of television electronic products at PT. Panasonic Goblet.
Relationship between Service Quality and Customer Satisfaction
Authors: Abbas Muhammad
Published: July 2023

This research aims to measure the level of customer satisfaction in the dimensions of service quality, namely physical evidence, reliability, responsiveness, assurance and empathy. The research method uses a questionnaire distributed to 65 Damri Bus passengers. After the results were obtained through the reliability and validity tests, they were analyzed using Multiple Linear Regression with the SPSS 17.0 for Windows program in which the classical assumption test, multicollinearity test, heteroscedasticity test, normality test, t test, f test and coefficient of determination (R2) test were carried out. Based on the analysis conducted, it is concluded that service quality (SERVQUAL) affects the level of customer satisfaction both individually and simultaneously and is empirically proven. The dominant factor that most affects customer satisfaction on Damri Buses in Makassar City is physical evidence.
Factors Influencing Consumer Decisions to Purchase Hijab Products Online on Instagram Social Media
Authors: Latief Fitriani , Murti Rahel Sri
Published: July 2023

The purpose of this study is to investigate the cultural, social, personal, and psychological factors that are believed to influence consumers' online purchasing decisions. Data analysis employs multiple linear regression analysis techniques and is validated using SPSS software. This study is a form of quantitative research with a sample size of 96 respondents. The selected sample was a student from the Nobel Institute of Technology and Business Indonesia who was known to have used Instagram for online purchasing, making the data obtained reliable and pertinent. Individual factors and psychology have a greater impact on consumers' online hijab decisions, as demonstrated by the findings.
Regional Original Income and Special Allocation Funds on Economic Development
Authors: Rahman Zainuddin
Published: July 2023

This study aims to determine whether there is a natural and significant effect of Regional Original Income (PAD) and Special Allocation Funds (DAK) on Economic Development in Pinrang Regency and find the most dominant variables affecting economic development in Pinrang Regency. This research was conducted at the Regional Personnel Agency of Pinrang Regency. The type of data used in this study is secondary data, namely data sourced from documents, publications, or unique publications from related agencies, especially in Pinrang Regency. Data collection techniques in this study use the method of documentation. The data that has been collected will be tested by several stages of testing, namely descriptive statistical tests, classical assumption tests consisting of (normality test, multicollinearity test, autocorrelation test, heteroscedasticity test), and testing all hypotheses through the coefficient of determination test, partial test (t-test ) and simultaneous test (f test). The results showed that the Regional Original Income (PAD) variable significantly affected economic development in Pinrang Regency. Meanwhile, the Special Allocation Fund hurts economic growth in the Pinrang district.
Application of the Economic Value Added (EVA) Concept as a Measuring Tool for Financial Performance
Authors: Nianty Dara Ayu , Safitri Putri Aulia
Published: July 2023

This study aims to determine the application of Economic Value Added (EVA) to financial performance at PT. XL Axiata, Tbk. The sample in this study is the financial performance of PT. XL Axiata, Tbk for three years. This research method uses the documentation method. The data used in this study is secondary data obtained from financial reports on the Indonesian Stock Exchange website. The data obtained is then processed by simple regression. Based on the analysis that has been done, it can be concluded that the financial performance of PT. XL Axiata, Tbk. This can be seen from the EVA value, which continuously decreases yearly until it reaches a negative EVA value so that PT. XL Axiata, Tbk could not generate returns per the expectations of shareholders. Also, evaluating financial performance using the EVA method strongly supports assessing financial performance based on financial ratios. This performance appraisal method gives the result that PT. XL Axiata has continuously experienced a decline in financial performance. However, with EVA, shareholders can see the size of the return generated by PT. XL Axiata Tbk for shareholders and whether the rate of return follows the shareholders' expectations, exceeding the cost of capital for the investment it makes
The Effect of Transformational Leadership Style and Job Satisfaction on Employee Performance
Authors: Basalamah Muhammad Syafii A
Published: July 2023

This study aims to analyze and determine the effect of transformational leadership style and job satisfaction on employees of PT. Mandiri Utama Finance Makassar City. The population in this study were PT Mandiri Utama Finance employees, totaling 225 employees. The total population used was 68 people which were determined based on the purposive sampling method. The data source used is primary data, namely data obtained directly from respondents by distributing questionnaires to the object to be studied. The data analysis method that will be carried out consists of descriptive statistical analysis, validity test, reliability test, normality test, multicollinearity test, heteroscedasticity test, and hypothesis testing through multiple linear regression analysis, t test, f test and coefficient of determination test. The results of this study, both partially and simultaneously, indicate that the transformational leadership style and job satisfaction have a positive and significant effect on the performance of employees of PT. Mandiri Utama Finance Makassar City.
The Impact of Work Environment and Competence on Employee Performance
Authors: HA Ismail
Published: July 2023

This study seeks to empirically investigate the relationship between Work Environment and Competence and Employee Performance at the Ministry of Religion of Tana Toraja Regency. This study's demographic consisted of forty employees of the Ministry of Religion Office of Tana Toraja Regency. Non-probability sampling, namely saturated sampling, in which all members of the population are used as samples, will be employed as a supplementary technique. The data source employed is primary data, i.e., data obtained directly from respondents by distributing questionnaires (research questionnaires) to the objects under investigation. The method of data analysis includes descriptive statistical analysis, tests of validity and reliability, and testing of hypotheses via multiple linear regression analysis, t test, f test, and coefficient of determination test. Partially and simultaneously, the results of this study indicate that the work environment and employee competence have a positive and statistically significant effect on employee performance at the Office of the Minister of Religion of Tana Toraja Regency.
Accounts Receivable Turnover Analysis and Company Merchandise Inventory Turnover
Authors: Haeruddin Sitti Hartati
Published: July 2023

This study aims to determine the level of trade receivables and merchandise inventory turnover at PT. Fajar Mas Karyatama. This research was conducted with quantitative descriptive techniques, namely by calculating the turnover of accounts receivable and merchandise inventory and collecting data by means of survey and documentation methods. The results showed that the turnover of trade receivables in 2011 was 15 times, in 2012 as many as 13 and 2013 as many as 12 or when calculated in the number of days for 2011 for 24 days, in 2012 for 28 days while in 2013 for 30 days. Meanwhile, merchandise inventory turnover in 2011 was 3 times, 2012 was 4 times and in 2013 4 times or when calculated in the average number of days the goods were stored in the warehouse in 2011 for 120 days, in 2012 for 90 days and for 2013 for 90 days.
Several Factors Affecting Taxpayer Compliance During the Covid-19 Pandemic
Authors: Junaid Asriani , Ahmad Hamzah , Salsabila Putri Aisyah , Amiruddin Amiruddin , Ikhtiari Kirana
Published: July 2023

The purpose of this study was to determine the effect of tax policies and business strategies on MSME actors during the pandemic in Kolaka City. This type of research includes quantitative descriptive research. The population in this study were SMEs in Kolaka District, Kolaka City. The method used in the selection of the sample is purposive sampling method and set a sample of 52 respondents based on the established criteria. The results of this study are Tax Policy has a Positive and Significant Effect on MSME Actors in the Pandemic Period in Kolaka City. The Tax Policy in question is Tax Incentives for Taxpayers affected by the 2019 Corona Virus Disease Pandemic. And the second is a Business Strategy that has a Positive and Significant Effect on MSME Actors during the pandemic in Kolaka City. The Business Strategy in question is online marketing. Based on the results of the discussion, it can b e concluded that the tax policy in this case is tax intensive for MSME actors, it is felt to be very beneficial for MSME actors during the pandemic and this tax policy provides benefits for MSME actors to increase knowledge about taxation. By using a Business Strategy, online marketing is the right strategy for MSME actors to re-increase their business activities during the pandemic
Perception of State Civil Apparatus towards Income Tax Article 21: Maximum Four Tax Theory Approach
Authors: Adil Muhammad
Published: July 2023

This study aims to determine the perception of ASN towards the collection of Income Tax Article 21 whether it is in accordance with the theory put forward by Adam Smith, namely the Theory of Four Maximum Taxes. This study uses a qualitative descriptive data analysis method with data collection techniques, namely interviews. Researchers conducted interviews with taxpayers who work at the Mamajang Sub-District Office, Makassar City. Based on the results of this study, it can be concluded that the collection of Income Tax Article 21 on ASN can generally be stated to be in accordance with the theory of "Four Maximum Taxes". This is assessed based on the four criteria, namely equity, certainty, convenience of payment, and economics of collection.
Aculturación y relaciones intergeneracionales: estudio de casos en las familias de inmigrantes chinos en Portugal
Authors: Jin Yangmin , Gómez-Pellón Eloy
Published: July 2023

El objetivo del presente artículo es examinar los cambios culturales y los conflictos intergeneracionales acaecidos en el seno de las familias de inmigrantes chinos llegados a Portugal a partir de 1990. Para ello se ha aplicado el estudio de casos sobre cinco familias inmigrantes procedentes de la provincia de Zhejiang de China. Se concluye que los padres y los hijos se aculturan a diferentes velocidades en la sociedad portuguesa, como resultado de la “brecha de aculturación”. No obstante, se observa que los conflictos entre padres e hijos, que perjudican la cohesión familiar, y las complejas relaciones intergeneracionales no sólo son efectos de dicha brecha de aculturación, sino que también se relacionan con las trayectorias vitales de los inmigrantes.
Aprendizagem e educação de adultos em Portugal e na UE: relevância sociológica, desafios conceptuais e resultados de investigação
Authors: Ávila Patrícia
Published: July 2023

Este artigo tem como enfoque a investigação sobre a participação da população adulta em processos de aprendizagem e educação. Discute e sistematiza as principais perspetivas analíticas, dispositivos metodológicos e resultados de investigação, situando, numa perspetiva comparada e temporalmente alargada, a evolução registada em Portugal neste domínio. Sublinham-se as acentuadas desigualdades sociais associadas à aprendizagem ao longo da vida, a complexidade e multiplicidade dos fatores que condicionam ou favorecem a participação, destacando a centralidade das políticas públicas. Abordam-se, ainda, as implicações sociais destes processos, para os indivíduos e para as sociedades, e defende-se a necessidade de reforçar a investigação sociológica neste campo.
Distinct states of nucleolar stress induced by anti-cancer drugs
Authors: Potapova Tamara A. , Unruh Jay R. , Conkright-Fincham Juliana , Banks Charles A. S. , Florens Laurence , Schneider David A. , Gerton Jennifer L.
Published: July 2023

Ribosome biogenesis is one of the most essential and energy-consuming cellular functions. It takes place mainly in the nucleolus. For cancer cells, the nucleolar function is especially important due to the high demand for ribosomes to support continuous proliferation. The goal of this study was to assess the effects of existing chemotherapy drugs on the nucleolar state. For this, we conducted an imaging-based screen for anticancer drugs that induce morphological re-organization consistent with nucleolar stress. For a readout, we developed a novel parameter termed “nucleolar normality score”, which measures ratios of dense fibrillar center and granular component in the nucleolus and nucleoplasm. We show that multiple classes of drugs cause nucleolar stress, including DNA intercalators, inhibitors of mTOR/PI3K, heat shock proteins, proteasome, and cyclin-dependent kinases (CDKs). Different classes of drugs induced morphologically and molecularly distinct states of nucleolar stress. By applying phospho-proteomics and live imaging strategies, we characterized in detail the nucleolar stress induced by inhibition of transcriptional CDKs, particularly CDK9, the main CDK that targets RNA Pol II. Inhibition of CDK9 dramatically reduced rRNA production, caused dissociation of RNA Polymerase I catalytic subunit POLR1A from ribosomal DNA and dispersal of the nucleolar granular component, a stress we refer to as the “bare scaffold” state. We identified multiple nucleolar CDK phosphorylation substrates, including RNA Pol I – associated protein Treacle, and demonstrated that CDK9 can phosphorylate Treacle in vitro. This implies that transcriptional CDKs coordinate the action of RNA pol I and RNA pol II. Furthermore, molecular dynamics analysis of the endogenous nucleolar protein NPM1 demonstrated that CDK inhibition vastly increased its mobility, consistent with the loss of nucleolar integrity. We conclude that many classes of chemotherapy compounds directly or indirectly target nucleolar structure and function, and recommend considering this in anticancer drug development.

Types of nucleolar stresses identified in this study.
(1) DNA intercalators and RNA Pol inhibitors induced canonical nucleolar stress manifested by partial dispersion of GC components and segregation of nucleolar stress caps. (2) Inhibition of mTOR and PI3K growth pathways caused a metabolic suppression of function without dramatic re-organization of nucleolar anatomy. (3) Inhibitors of HSP90 and proteasome caused proteotoxicity – loss of protein homeostasis and accumulation of misfolded and/or not degraded proteins. (4) Inhibition of transcriptional CDK activity resulted in the loss of interaction between rDNA, RNA Pol I, and granular component proteins, resulting in almost complete nucleolar dissolution, with an extended bare rDNA scaffold and few associated proteins remaining.
Coral affected by stony coral tissue loss disease can produce viable offspring
Authors: Mendoza Quiroz Sandra , Tecalco Renteria Raúl , Ramírez Tapia Gandhi Germán , Miller Margaret W. , Grosso-Becerra Maria Victoria , Banaszak Anastazia T.
Published: July 2023

Stony coral tissue loss disease (SCTLD) has caused high mortality of at least 25 coral species across the Caribbean, with Pseudodiploria strigosa being the second most affected species in the Mexican Caribbean. The resulting decreased abundance and colony density reduces the fertilization potential of SCTLD-susceptible species. Therefore, larval-based restoration could be of great benefit, though precautionary concerns about disease transmission may foster reluctance to implement this approach with SCTLD-susceptible species. We evaluated the performance of offspring obtained by crossing gametes of a healthy P. strigosa colony (100% apparently healthy tissue) with that of a colony affected by SCTLD (>50% tissue loss) and compared these with prior crosses between healthy parents. Fertilization and settlement were as high as prior crosses among healthy parents, and post-settlement survivorship over a year in outdoor tanks was 7.8%. After thirteen months, the diseased-parent recruits were outplanted to a degraded reef. Their survivorship was ∼44% and their growth rate was 0.365 mm ± 1.29 SD per month. This study shows that even diseased parent colonies can be effective in assisted sexual reproduction for the restoration of species affected by SCTLD.
Ferramenta Bowtie na identificação de riscos em planos de integridade em projetos públicos
Authors: Feitosa Alan Negri , Pedro Filho Flávio de São , Carneiro Ricardo José Gouveia
Published: July 2023

Planos de Integridade são mecanismos de prevenção que estão em voga no contexto da Administração Pública brasileira. Dessa forma, este trabalho se propôs a investigar como Planos de Integridade podem contribuir para a prevenção de práticas antiéticas na gestão de projetos públicos? Para isso traçou como objetivo geral estudar a utilização de Planos de Integridade na prevenção de práticas antiéticas em projetos públicos. No que concerne à metodologia adotada, considerando o objetivo geral proposto, esta pesquisa é classificada como descritiva, haja vista que sua finalidade é descrever as propriedades, características e perfis relevantes do que se está analisando. Quanto ao método, adotou-se a Análise de Conteúdo. O material bibliográfico foi buscado por meio das plataformas de pesquisa Spell, Scielo e Google Acadêmico. A análise está fundamentada nos princípios de Habermas, pois almeja promover a interação de forma racional (Teoria da Ação Comunicativa). Como resultados ressaltou-se a necessidade de haver um sistema de controles internos bem estruturados, bem como gestão de riscos implementada. Identificou-se riscos de integridade que podem afetar projetos públicos como, por exemplo, nepotismo, conflito de interesses e fraudes, bem como a utilização de Planos de Integridade como meio de prevenção dessas condutas. Por fim, foi apontado que a ferramenta Bowtie se amolda ao segundo nível do modelo COSO ERM (Committee of Sponsoring Organizations of the Treadway Commission - Enterprise Risk Management – Integrated Framework), que trata da identificação de eventos de riscos.
Estratégia organizacional na construção de cenários disruptivos
Authors: Teixeira Ivandi Silva , Teixeira Regina Cleide Figueiredo da Silva , Rodrigues Junior Alfredo Alves , Santos Fabio Cardoso , Dias Denilson Vidal
Published: July 2023

O presente artigo busca analisar, a partir da conceituação de estratégia organizacional, e sua caracterização, o processo de inovação, em relação aos comportamentos das organizações, enquanto parte pulsante da sociedade, em momentos onde se verifica a quebra de etapas do processo de desenvolvimento, alcançando um sentido disruptivo, com cenários de inovação acentuados, como é o caso atual, onde, por diversas motivações, especialmente, de origem mais ampla, global, como no caso da pandemia de Covid-19, as estruturas, antes mais físicas, dos processos de gestão organizacional, foram reconstruídas para funcionarem em um ambiente tecnológico, calcado em relações, muitas vezes, virtuais, com maior velocidade, dinâmica e intensidade. A pesquisa é qualitativa, expositiva, de metodologia dedutiva. Conclui-se que, na busca por resultados que possam garantir a continuidade dessas organizações e atender as demandas, igualmente, ágeis e urgentes da sociedade de consumo, culturalmente digital, as estratégias organizacionais devem se tornar mais flexíveis e dinâmicas na construção de cenários, cuja conceituação de GODET (1997), define CENÁRIOS como sendo “um conjunto formado pela descrição de uma situação futura e do encaminhamento dos acontecimentos que permitem passar da situação de origem à situação futura”, a qual nos somamos em entendimento e relevância para soluções positivas a serem alcançadas.
Evaluation of Salivary Lactate Dehydrogenase Level as a Biomarker for Early Detection in Oral Cancer and Potentially Malignant Disorders: A Systematic Review and Meta-analysis
Authors: Sarma Arunima , Mishra Sunil S , Das Sukanya , Sawane Harshawardhan , Gaikwad Trupti
Published: July 2023

Introduction: Saliva diagnostics are emerging tools which are being explored as a non invasive method for early detection of oral premalignant lesions and Oral Cancer (OC). Salivary Lactate Dehydrogenase (LDH) is one such promising biomarker which has shown potential to be utilised in future for detection of premalignant lesions and conditions. The rationale behind this systematic review was to evaluate whether salivary LDH can be considered as biomarker for OC and Oral Potentially Malignant Disorders (OPMDs). Aim: To review the literature for levels of salivary LDH in patients with OC and OPMD. Materials and Methods: A comprehensive search was done and this systematic review was conducted in the Department of Oral Medicine and Radiology, Dr. DY Patil Dental College and Hospital, Pimpri, Pune, Maharashtra, India, following (Preferred Reporting Items for Systematic Reviews and Meta-analyses) PRISMA guidelines. The International Prospective Register of Systematic Reviews (PROSPERO) registration Identity Document (ID) was (CRD42022366117). Electronic data was searched through the database PubMed, ScienceDirect and Cochrane Library from 2012-2022. Observational and analytical studies, original longitudinal or case-control, randomised clinical trials, prospective controlled clinical trials with the inclusion of cases diagnosed with oral leukoplakia, Oral Lichen Planus (OLP), Oral Submucous Fibrosis (OSMF), OC and having salivary LDH levels reported were included. The data was collected from the studies that were included based on study design, eligibility criteria, histological differentiation, collection method, LDH level and the data were subjected to meta-analysis. Results: A total of 16 articles were included. The meta-analysis showed increased salivary LDH levels between cases with OC and Control Group (CG). The pooled estimate was 5.71 (95% CI: 3.89-7.53) with statistical significance of <0.05. In OSMF and controls the levels of salivary LDH was significantly increased. The pooled estimate was 30.38 (95% CI: 15.82-44.94) with statistical significance of <0.05. The level of salivary LDH among cases with premalignant lesions and controls was increased. The pooled estimate was 9.10 (95% CI: 3.45-14.75) with statistical significance of <0.05. In case of OLP and controls, the levels of salivary LDH were seen elevated. The pooled estimate was 6.76 (95% CI: 6.86- 20.38) with no statistical significance of p-value<0.05. Conclusion: To sum up, the results of this systematic review showed that levels of salivary LDH were higher in OC and OPMD patients than in healthy patients. Furthermore, the levels of salivary LDH are more in OC than OPMDs.
PTEN Immunoexpression in Atypical Endometrial Hyperplasia and Endometrioid Endometrial Carcinoma: A Research Protocol
Authors: Chandrakar Garima Akhil , Bhake Arvind , Vagha Sunita
Published: July 2023

Introduction: One of the major cancers affecting women is of Endometrial Carcinoma (EC). Therefore, its molecular characterisation remains important. Phosphatase and Tensin Homolog (PTEN) gene defects are one such molecular pathology commonly seen in lesion of atypical endometrial hyperplasia and EC. However, studies on PTEN immunoexpression in India are scarce. Aim: To study immunoexpression of PTEN and its correlation with various clinicopathologic parameters in lesion of atypical endometrial hyperplasia and EC. Materials and Methods: It will be carried out as a crosssectional study with prospective and retrospective design with sample size of 20 cases each in two groups- cases diagnosed on biopsy or surgical specimen of atypical endometrial hyperplasia and endometrioid endometrial carcinoma type -1, dividing them into sample size of 20 for each group. PTEN immunoexpression will be observed by immunohistochemical method on paraffin section of the tissue. The study would make the observation on the PTEN positivity by IHC in atypical endometrial hyperplasia and type-1 EC. The positive research of IHC will be compared for various other clinicopathologic parameters included in the study for both the endometrial lesion. The statistics of comparison will be drawn by using standard statistical test.
Gastrointestinal Manifestations and Liver Abnormalities in COVID-19: A Real-World Experience and a Novel COVID-19 Prognostic Index
Authors: Manrai Manish , Marwah Vikas , Peter Deepu , Mangal Vishal , Harikrishnan P , Mishra Yogendra , Sharma Manish , Pemmaraju Arpitha
Published: July 2023

Introduction: Gastrointestinal (GI) manifestations and liver function abnormalities have been reported in Coronavirus Disease-2019 (COVID-19). However, data is variable and lacking from the Indian Population. Moreover, the prognostic implication of these manifestations has not been well-defined. Aim: To determine the impact of COVID-19, on the gastrointestinal tract and Liver Function Test (LFT) and develop a prognostic model for mortality. Materials and Methods: An observational descriptive study was conducted in the Department of Internal Medicine at a temporary dedicated COVID-19 centre in a Tertiary Care Cardiothoracic Centre, Western Maharashtra, India. The hospital records of all the patients admitted from July 2020 to September 2020 were analysed. Clinical details and laboratory details were obtained from 589 Reverse Transcription– Polymerase Chain Reaction (RT-PCR) confirmed patients. The data was analysed and a prognostic scoring system was developed. Patients with positive Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) RT-PCR on nasopharyngeal or oropharyngeal swabs. The data was entered in Microsoft Excel 2010 worksheet and t-test or Mann-Whitney test was also applied to compare the mean of variables being studied by separation of living and deceased patients based on the normality of the quantitative data. Results: The mean age±SD of the study participants was 44.74±19.61 years. The majority {127/589 (21.56 %)} of the patients were in the age group of 51-60 years. A total of 5 (0.84%) out of 589 patients had diarrhoea, and 3 (0.51%) had vomiting at the time of admission. Elevated Aspartate Aminotransferase (AST), Alanine Transaminase (AST), Alkaline Phosphatase (ALP), Gamma-glutamyl Transferase (GGT), Lactate Dehydrogenase (LDH), Creatine Kinase Myocardial Band (CK-MB) was reported in non survivors in 45 (90%), 39 (78%), 15 (30%), 28 (56%), 48 (96%) and 49 (98%) out of 50 cases, respectively. The prognostic scoring system was developed with the following variables: age, Diabetes Mellitus (DM), symptomatic, breathlessness, albumin, AST, ALP, LDH, Prothrombin Time (PT), D-Dimer. The area under the curve, came out to be 0.91 and a cut-off value of three in the scoring system was able to predict death at a sensitivity of 85.5% and specificity of 79.6%. Conclusion: Gastrointestinal manifestations and abnormalities in LFTs are important extrapulmonary manifestations of COVID19. Patients with abnormal liver tests had higher risks of progressing to severe disease. Hence, LFT should be monitored and evaluated frequently during hospitalisation for COVID-19.
Partial Nephrectomy for Renal CancerA Phoenix Risen from the Ashes: A Case Series on Totally Laparoscopic Partial Nephrectomy with Review of Literature
Authors: Chawda Vishal , Joshi Abhijit , Shetty Prakash
Published: July 2023

Partial nephrectomy, also called Kidney-sparing Surgery (KSS) or Nephron-sparing Surgery (NSS), is an operation wherein, only a cancerous renal tumour or diseased renal tissue is surgically removed; leaving behind as much healthy renal tissue as possible. Understandably, it was initially preferred in patients with solitary kidney and those, with concurrent bilateral tumours. Over the first two decades of the 21st century, Partial Nephrectomy (PN) has become the standard procedure for many renal tumours; even in unilateral disease. This is because of early pick up due to significant developments in imaging modalities and also, due to better understanding of the biology of renal tumours. With advances in minimal access surgery, partial nephrectomy too has come under its ambit. In the present case series, it's fascinating journey has been discussed- its exciting rise, subsequent downfall and then its unique rise again; as the preferred surgical therapy for many renal tumours, around the world. The purpose of reporting the present case series on Laparoscopic Partial Nephrectomy (LPN) performed for renal cancer, was to share the authors’ early experience and results on the topic and to compare them with the world literature. Also, the aim was to underscore the fact that, in an advanced laparoscopy set up, with optimum patient selection and availability of advanced laparoscopic skills, it is an effective and feasible operation. Herein, the authors have described three cases of totally LPN and review of literature on the same. Over an average follow-up period of 23 months, all three patients continue to be asymptomatic and disease free.
A Comparative Analysis of Mandibular Ramus and Maxillary Sinus in Sex Determination among the Population of West Godavari, India: A Tool in Forensic Identification
Authors: Supriya Alapati Naga , Gayatri Saridena Udayasri Naga , Manyam Ravikanth , Swetha P , Supraja MHL , Meka Jyothi Pravallika
Published: July 2023

Introduction: The application of dental principles to legal issues is known as forensic dentistry. Among the skull’s various bones, mandible is the strongest and most diverse bone and is crucial in determining sex. It is been reported in many studies that maxillary sinus seems to be intact, although other bones may be severely deformed and can be applied to determine sex. Aim: To assess, analyse and compare the morphometric analysis of maxillary sinus and ramus of mandible for gender determination using digital Orthopantamograph (OPG). Materials and Methods: A cross-sectional study comprising of 64 individual radiographs (32 men and 32 women) were measured for mandibular ramus (maximum ramus width, condylar and coronoid height) and maxillary sinus length, width and compared bilaterally. The results were tabulated and statistically analysed using discriminant functional analysis after the mean values were calculated. Results: In this study, the overall measurements of mandibular ramus were more in males than females whereas maxillary sinus measurements were more in females when compared with males. Condylar length (right and left), width of ramus (right) and width of maxillary sinus (left) were found to have statistical significance in determining the gender (p-value<0.001,0.024,0.024). Length of the condyle showed highest accuracy of 73.8% in gender determination. Conclusion: This study suggests that the mandibular ramus and maxillary sinus measurements using OPG are helpful in dealing forensics, with condylar height being the most accurate indicator for gender determination.
Single Anterior Tooth Crossbite Correction in Mixed Dentition using Versatile 2x4 Appliance Along with Posterior Bite Plane: A Case Report
Authors: Maheshkumar K. , Chowdhary Nagalakshmi , Manjula K. T. , Anuraaga A. Thirumagal , Shaji Nikhitha Elsa , Nandini Ambika
Published: July 2023

The period of mixed dentition is considered to be one of the most appropriate ages for getting an orthodontic treatment. Most parents have a misconception that orthodontic treatment should only be started after all of the permanent teeth have fully erupted. Early mixed dentition patients with anterior crossbites and ectopic incisors are treated versatile 2x4 appliance along with posterior bite plane. This appliance has many benefits over alternative methods, including complete control over anterior tooth positioning, excellent patient acceptance, no patient adjustment needed, and the ability to accurately and quickly position teeth. The present case report refers who reported to the department with complains irregularly placed teeth which was managed with 2 X4 appliance.
Knowledge Level of the Anganwadi Workers on Integrated Child Development Service: A Study in Manipur, India
Authors: Brahmacharimayum Dolica , Das Puspita , Boruah Munmi , Nath Meghali , Mishra B. K.
Published: July 2023

Integrated Child Development Service (ICDS) is a Government program in India that mainly focuses on child and maternal health to address the health, nutrition, and development needs of children, pregnant women, nursing mothers, and adolescent girls. The Anganwadi workers are the front-line workers who are responsible for transferring the services of ICDS to children and mothers. As the ICDS program is designed for vulnerable section of the society like women and children it is important not only from health point of view but also from the point of socio economic as well as for a better future generation. Success of any program depends on the knowledge of stakeholders about the concept, objective, functions of the program. Anganwadi workers are grass-root level functionaries who are implementing the program at ground level. Their knowledge level has impact on implementation and output of the programme. This paper attempts to explore the knowledge level of AWWs regarding not only the activities of ICDS but also their knowledge on different nutrients its source and importance which will act as a guide to policy makers, planners, extension functionaries, scientist, researchers, students and health personnel. For this purpose 150 respondents from Imphal East, Manipur were selected randomly and interviewed with a structured schedule. The data were analyzed using appropriate statistical methods. The finding of the study revealed that majority of the AWWs had medium level of knowledge regarding the objectives and functions of ICDS. Further it was found that only 16 per cent of the respondents had high knowledge level regarding Vitamin A, 4.67 per cent regarding Iron, 0 per cent for Calcium and 15.33 per cent for Vitamin C respectively. Moreover, it was found that age and experience of the respondents had a negatively significant relationship with their knowledge while their educational qualification was correlated positively. Thus, the present study strongly felt the need of improving the quality of knowledge and awareness among Anganwadi workers about the various activities of ICDS and the nutritional requirements of mother and children which needs regular training, awareness and orientation programs along with group discussion and observations.
Estimating Runoff for Bamnidhi Watershed Using SCS Curve Number Approach and Geospatial Technique
Authors: Yadav Usha , Ghodichore Nikhil , Dileshwari
Published: July 2023

Water is one of the most valuable natural resources and a vital component of the socioeconomic development of a nation. Water resources in India and throughout the world are under a lot of stress as a result of the limited supply and rising demand. Water availability of a region can be better estimated using rainfall runoff relationship. Runoff is mostly produced as a result of rainfall, which is a significant part of the hydrologic cycle. In this study, the rainfall-runoff relation of the Bamnidhi watershed in Chhattisgarh (India) is studied using SCS CN method. Various inputs such as HSG map and land use land cover were overlaid in ArcGIS platform for estimation of weighted curve number, based on which the runoff is estimated. The results of the study indicate that CN values range from 30 to 97. The lowest runoff potential is observed for forest regions having CN value of around 30, while highest runoff potential is observed for water bodies. The total runoff is found to be around 3.6 Million m3 for the period 2011 to 2020, which is about 10 to 25 percent of the total rainfall.
Sowing Time, Plant Growth Regulators and their Application Scheduling Affect Quality Traits of Wheat (Triticum aestivum L.)
Authors: Kumawat Rohit Kumar , Tiwari Gyanendra , Ramakrishnan R. Shiv , Debnath Supriya , Thakur Satyendra , Bhayal Divya , Samaiya R. K. , Upadhyay Anubha , Bhayal Lalita
Published: July 2023

A field experiment was conducted during winter (rabi) seasons of 2020-21, 2021-22 at Research farm, seed technology research center, Department of Plant Physiology, College of Agriculture, JNKVV, Jabalpur, Madhya Pradesh to study the response of sowing time, plant growth regulators and their application scheduling on quality traits of wheat. The experiment consisting of 3 sowing dates (D1-15th November, D2-15th December, D3 - 15th January), 3 Spray scheduling at different stages (A1-Vegetative stage, A2-Anthesis stage, A3-Vegetative + Anthesis stage) and 7 Plant Growth Regulators (H1: Cycocel @1000 ppm, H2: Salicylic acid@400ppm, H3: Salicylic acid@800ppm, KCl@1%, H4: Ascorbic acid@10ppm, H5: Thiourea@400ppm, H6: Water spray and H7: Control) making 63 treatment combinations, replicated thrice in a split plot design. The crop sown at normal sowing time showed significantly positive affect on quality traits of wheat than the late sown crop. Spraying of plant growth regulators salicylic acid@400ppm and 800ppm along with other plant growth regulators at different growth stages have positive effect on seed quality and improve germination %, seedling length, seedling dry weight, seed vigour index I and II of wheat crop.
Bone Metabolism Assessment in Hemodialysis Patients by Using Carboxy-Terminal Cross-Linked Telopeptide of Type I Collagen
Authors: Alawany Rehab Anter Albahy , Negm Manal Saad Ahmed , Hazzaa Sahar Mohy El-Dine , Elbedewy Mohamed Mohamed Mokhtar
Published: July 2023

Aims: To evaluate the carboxy-terminal telopeptide of type I collagen (CTX I) as a serum bone metabolism marker in hemodialysis patients.
Study Design:  Cross-sectional observational.
Place and Duration of Study: Hemodialysis unit of Tanta University Hospital, between October 2018 and March 2020.
Methodology: 80 male patients aged from (18-65y) on regular hemodialysis were included. All patients were subjected to: history taking, full clinical examination, laboratory investigations including: Serum calcium, serum phosphorus, serum albumin, alkaline phosphatase (ALP), Intact parathyroid hormone (iPTH), serum carboxy-terminal cross linking telopeptide (CTX I) and dual energy X ray absorptiometry (DEXA) scan of the lower third of the right fibula to evaluate bone mineral density (BMD) and patient were divided according to bone mineral density T score into two groups "normal and osteopenic groups".
Results: There is significant difference between normal and osteopenic groups according to iPTH (p = 0.001) and ALP (p = 0.001) and CTX I (p = 0.001), but there is non-significant difference between normal and osteopenic groups according to serum calcium (p =0.239), serum phosphorus (p =0.672), serum albumin (p =0.749) and corrected serum calcium (p = 0.314).There was negative significant correlation between CTX I and DEXA scan, and between DEXA scan and iPTH and ALP. There was positive significant correlation between CTX I and iPTH, ALP and serum albumin and there was positive significant correlation between iPTH and ALP. At cutoff 2.0 ng/ml CTX I can significantly diagnose osteopenia in hemodialysis patients with 93% sensitivity, 95% specificity and accuracy of 92%. It had positive predictive value of 95% and negative predictive value of 83%, in multiple regression analysis the increase in iPTH and CTX I was the significant predictor of osteopenia.
Conclusion: This study showed high association between CTX I and other established markers of bone metabolism and BMD by DEXA demonstrating the potential utility of CTX I as marker of bone resorption in renal bone disease.
Effectiveness of Cognitive Behavioral Therapy for Post-partum Depression in Low and Middle-income Countries: A Systematic Review
Authors: Arisoyin Abimbola Eunice , Salawu Mujeeb Adedeji , Folorunsho Ibrahim Lanre , Olaleye Kehinde Tolulope , Afolayan Adebola Yewande , Adeyemo Damilola Abiola , Mbaezue Rheiner Nnenna , Ibeneme Chidalu Nkeyonyere , Ballagan Jashanpreet Singh , Rai Shilpa , Fagbenle Olasumbo Elizabeth , Oraekwute Ifeyinwa Monica , Pantoja Stefany Carolina Lopez , Okunromade Omolola , Haddad Mark Majid
Published: July 2023

Background: Post-partum depression (PPD) is a prevalent psychological condition affecting 10-20% of women following childbirth, with higher rates in low and middle-income countries (LMICs) due to limited resources, poor access to mental health care, and sociocultural stressors. Cognitive Behavioral Therapy (CBT) is an evidence-based intervention for treating PPD in high-income countries, but its effectiveness in LMICs remains underexplored.

Aim: This systematic review aims to synthesize evidence on CBT's effectiveness for post-partum women in LMICs, examine cultural and contextual factors, and provide recommendations for culturally-sensitive interventions.

Methods: Following PRISMA Statement 2020 guidelines, a systematic search was conducted in electronic databases such as PubMed, PsycINFO, and Web of Science to identify studies evaluating CBT's effectiveness for post-partum women in LMICs. A narrative synthesis was used to analyze and synthesize findings, considering the heterogeneity in study designs, populations, and outcome measures.

Results: The review included five studies, all of which reported a more significant decrease in Edinburgh Postnatal Depression Scale (EPDS) scores for the CBT intervention group compared to the control group. The studies varied in terms of populations, settings, and CBT delivery modes, with telephonic CBT, in-hospital CBT, and in-person CBT being utilized.

Conclusion: The findings from this systematic review suggest that CBT may be effective in reducing depressive symptoms among post-partum women in LMICs. Further research is needed to strengthen the evidence base, refine intervention strategies, and develop more effective, accessible, and culturally-appropriate interventions for PPD in LMICs. Addressing these recommendations will contribute to better mental health outcomes for post-partum women and their families in developing countries.
Associations Between Neighborhood-Level Racial Residential Segregation, Socioeconomic Factors, and Life Expectancy in the US
Authors: Khan Sadiya S. , McGowan Cyanna , Seegmiller Laura E. , Kershaw Kiarri N.
Published: July 2023

This cross-sectional study evaluates the association between neighborhood-level residential segregation and life expectancy and aims to determine the proportion mediated by representative neighborhood-level socioeconomic factors.
Synthesis of Carboxylic Acids from Benzamide Precursors Using Nickel Catalysis
Authors: Bulger Ana S. , Witkowski Dominick C. , Garg* Neil K.
Published: July 2023

This chapter describes the procedure for synthesis of carboxylic acids from benzamide precursors using nickel catalysis. It presents some of the important points to be considered, the conditions that need to be maintained, characterization data, and the reagents required, as well as the techniques used and the equipment setup that are vital to carrying out the process. Carboxylic acids are ubiquitous functional groups found in natural products and drugs but can be difficult to carry through multistep syntheses due to their acidity. Many methods for accessing carboxylic acids proceed from oxidation of alcohols or aldehydes to the corresponding carboxylic acid, but methods to access carboxylic acids from amide precursors are limited. The chapter also describes the hazards associated with working with chemicals and the ways to deal with these hazards.
A scoping review of workplace health promotion interventions for chronic diseases in Australia
Authors: Arnold Leonie , Harris Katherine , Weale Victoria
Published: July 2023

Objective

The aim of this study is to systematically chart and summarize the literature pertaining to workplace health promotion (WHP) interventions targeting the five main modifiable lifestyle risk factors for chronic disease, including smoking, nutrition, alcohol, physical activity, overweight/obesity (SNAPO) in Australian workers.

Methods

A scoping review was performed using the framework of Arksey and O’Malley. MEDLINE, EMBASE, CINAHL, and SCOPUS were searched to identify peer-reviewed publications that evaluated primary or secondary WHP interventions which targeted one or more modifiable risk factor (SNAPO).

Results

A total of fifty-six articles were included in the review. The findings revealed a heterogeneous nature of WHP intervention design and evaluation. The majority of the interventions focussed on physical activity, with fewer targeting the other four main modifiable risk factors. Health care and white-collar workers were most frequently targeted, with less attention paid to other worker groups. The review also found that many interventions had a duration of three months or less.

Conclusions

Significant gaps have been identified in relation to the occupational role, risk factors targeted, and intervention length. This review also highlights the need for further research to be conducted to determine the efficacy of interventions to facilitate the development of a framework for WHP interventions to reduce the risk and prevalence of chronic disease.