bluuebunny/crossref_metadata_2025 huggingface dataset:
Przydatność oceny stężenia łańcuchów lekkich neurofilamentów w surowicy w codziennej praktyce klinicznej
Authors: Żur-Wyrozumska Kamila
Published: January 2025

Neurofilamenty są składnikami cytoszkieletu, a wzrost ich stężenia w surowicy jest wykładnikiem uszkodzenia neuroaksonalnego. Oznacza to, że są markerem uszkodzenia ośrodkowego układu nerwowego. Ich szczególne znaczenie jest obecnie badane w wielu chorobach neurologicznych, zwłaszcza w stwardnieniu rozsianym, stwardnieniu bocznym zanikowym, czy w urazach mózgu. W stwardnieniu rozsianym stężenie łańcuchów lekkich neurofilamentów w surowicy jest rozpatrywane jako predyktor krótkoterminowej progresji choroby, długoterminowej progresji choroby oraz jako biomarker odpowiedzi na leczenie modyfikujące przebieg choroby. Ponieważ neurofilamenty są markerem tkankowo specyficznym, a wzrost ich stężenia odzwierciedla utratę neuronów w czasie rzeczywistym, wydają się one prostym i użytecznym narzędziem oceny aktywności choroby.
Epstein–Barr virus infection and the risk of developing multiple sclerosis
Authors: Kuczko-Piekarska Ewelina
Published: January 2025

Despite increasing amounts of data regarding the pathogenesis of multiple sclerosis (MS), its etiology remains unknown. MS is believed to develop by interplay of genetic predispositions and environmental factors, including infectious ones, which disturb proper immune surveillance. More and more data indicate that the infectious agent is the Epstein–Barr virus (EBV). Although infection with it is usually asymptomatic in childhood, the ability of the virus to convert into a latent form with limited gene expression allows it to avoid host immune surveillance. It initiates a cascade of immunological processes leading to severe clinical implications, e.g., in the development of autoimmune diseases. Previous studies have shown that anti-EBV antibodies exist in almost all patients with multiple sclerosis. The most extensive population-based study in recent years covered US Army conscripts and found that the risk of developing multiple sclerosis is 32 times higher after infection with this virus. Determining the exact relationship between the Epstein–Barr virus and multiple sclerosis, including assessing the influence of genetic and environmental factors on this correlation, may be very important for understanding pathogenesis of multiple sclerosis and other autoimmune diseases. Such insights will also enable the identification of targets for future personalized therapies, especially in the context of increasingly widely used B cell depletion therapies.
Adaptive Property Reuse for Social Housing: Benefits, Challenges, and Best Practices
Authors: Sanchaniya Rashmi Jaymin , Černeckienė Jurgita , Gudumasu Naga Shilpa , Kundziņa Antra
Published: January 2025

This study examines the adaptive reuse of properties for the development of social housing, focusing on the benefits, challenges, and best practices associated with this approach. Through a comprehensive literature review and analysis of case studies, the research investigates how adaptive reuse can address housing shortages while promoting sustainable urban development. The study identifies key economic, environmental, and social benefits of adaptive reuse in social housing, including cost savings, reduced environmental impact, and community revitalisation. It also explores the technical, financial, regulatory, and social challenges often arising in such projects. The research presents a detailed analysis of successful adaptive reuse case studies, highlighting effective strategies to overcome common obstacles. Based on these findings, the study proposes a set of best practices for planning, designing, and implementing adaptive reuse projects in social housing. The paper concludes with policy recommendations and suggestions for future research, highlighting the potential of adaptive reuse to contribute significantly to sustainable and inclusive urban housing solutions.
Benefits Of Omega-3 In Peruvian Anchoveta: A Review Of Its Impact On Health
Authors: Herrera- Cruz Jorge Patrocinio , Castro- Rojas Miriam , Cornejo Rodolfo , Delgado -Flores Hilda , Minaya- Agüero Carmen del Pilar , Martínez- Albán Pascual Alejandro , Zúñiga- Vargas Oscar Alberto
Published: January 2025

Objectives: The objective of the research was to analyze the current state of knowledge about Omega-3 in the Peruvian anchovy to understand its positive effects on health and promote its adequate consumption.
 
Theoretical framework: The Omega-3 fatty acid present in the Peruvian anchovy is widely known by the scientific community, but its information has not been disseminated enough to know its positive effects in the treatment of inflammatory and autoimmune diseases.
 
Method: The positive effects of Omega-3 fatty acid on health were explored from various perspectives, highlighting its anti-inflammatory action and potential in the prevention and treatment of chronic diseases.
 
Results and discussion: The anchovy, abundant in the Peruvian sea and economic for its availability of catch by the fishing fleet, offers an accessible alternative without compromising the nutritional content, especially relevant in regions with low economy where other sources of Omega-3 are unreachable. It is concluded that anchovy is an accessible source of Omega-3 with considerable nutritional and economic value. Consumption improves public health by preventing chronic and autoimmune diseases.
 
Implications of research: Promote public health policies that include anchovy to maximize its benefits to society, especially in vulnerable populations by ensuring food security and access to low-cost animal protein.
 
Originality/Value: It is essential to promote public health policies that include anchovy in accordance with the ecosystem approach applied to fisheries, food security and sustainable development goals. a rethinking of dietary recommendations is suggested, especially in vulnerable populations in Peru.
Analysis of Shrinkage in Metal Injection Molding
Authors: Šarić Emir
Published: January 2025

Maintaining component dimensions in metal injection molding (MIM) is difficult because of
significant component shrinkage in the sintering step and shrinkage variation. Most of the
shrinkage variation in MIM is due to density inhomogeneity in moldings (greens), induced in the
injection molding step. Therefore, the focus of this research was to clarify the relationship between
injection molding parameters and shrinkage of a ring-shaped component molded into a four-cavity
split mold. Material used in research was Catamold 310N in the form of ready to mold granules.
An experiment, according to a 2k factorial design, was performed to evaluate the effects of holding
pressure profiling on shrinkage at different levels of coolant temperatures and fill rates. Results
showed that the interaction of holding profile and coolant temperature has the most influence on
the mean shrinkage. This finding offers a possibility to maintain the component dimensions in MIM
by using the revealed interconnection between holding pressure profile and mean shrinkage.
Level of awareness towards keratoconus among students of Bisha University, Bisha Saudi Arabia
Authors: Alshehri Merai , Alamri Malik , Alaklabi Sami , Alshmrani Saud , Hajlaa Abdullah , Alqahtani Saif , Albogami Sultan , Almuawi Abdullah , Alghamdi Mohammed , Alghuthaymi Abdulaziz , Alsalouli Faisal , Almuwai Abdulmalik , Alshahrani Faisal , Kadsah Nawaf
Published: January 2025

Objective:
This study aimed to assess the level of awareness of keratoconus among students of Bisha University, Saudi Arabia.
Methods:
This was a descriptive cross-sectional study that utilized data from a sample of 402 students of Bisha University in Saudi Arabia. The participants completed the self-administered online questionnaires and ensured anonymity.
Results:
Nearly three-quarters (75.1%) of the students demonstrated low awareness while about one-quarter (24.9%) had high knowledge about keratoconus. The majority (60.9%) of the students reported being familiar with keratoconus; with a notable proportion had heard about it from social media sites (34.3%) and doctors (33.0%). Nearly half (47.0%) of the students knew that keratoconus could lead to myopia and about one-third (31.1%) of them were aware that the condition is hereditary. The common risk factors and symptoms reported were eye rubbing (30.3%) and constant change in the size of glasses (27.1%), respectively. The study established a statistically significant association between all the factors including age, sex, college, source of knowledge, and the level of awareness about keratoconus with p-values of
Efficacy, safety, and risk assessment of antipsychotics and antidepressants for behavioral and psychological symptoms of dementia (BPSD): a narrative review
Authors: Alsultan Feras , Althabtah Shahad , Sangoura Rawan , Aljardan Salman , Alharbi Hamad , Nami Moath , Alameeri Zainab , Alharbi Abdullah , Alfehaid Mohammed , Mukrim Mohammedelamin
Published: January 2025

Dementia is one of the most common neurodegenerative disorders that annually affects over 55 million people worldwide; behavioral and psychological symptoms of dementia (BPSD), including anxiety, aggression, and depression, reduce the quality of life. The pharmacological interventions applied as a treatment of BPSD comprise antipsychotics, antidepressants, and sedatives. They include serious side effects such as increased mortality risk, cognitive impairment, and extrapyramidal syndromes. Moreover, the type of treatment applied must address the patient's needs. Evidence suggested that a patient's response to the medications might differ depending on the general health status, age, and the type of dementia present. An analysis of scientific articles included a systematic search in the PubMed database for articles published between the years 2018 and 2024. The search identified 93 papers pertinent to the pharmacological interventions of BPSD, where keywords were "antipsychotics," "antidepressants," "outcomes," and "side effects." The medications' effectiveness and safety were evaluated, in addition to concerns in elderly patients. Pharmacological interventions vary in efficacy, with atypical antipsychotics being moderately effective but linked to significant side effects, including metabolic disturbances and cardiovascular risks. The treatment selection must consider the patient's clinical profile, underlying dementia type, and potential drug interactions. Careful monitoring and individualized treatment plans are crucial, especially for elderly patients at higher risk of adverse outcomes. Although treatments with antipsychotics and other relatively safe drugs might reduce the symptoms of BPSD, their usage should be guarded given the side effects, especially in frail elderly patients.
Effective Teaching Methods and Strategies for Inclusion
Authors: Andrea Carroll
Published: January 2025

Gender equality in education is a matter of social justice, concerned with rights,opportunities and freedoms. Unfortunately, there are many schools today that is still ineducation prioritize boys over girls in classroom. This article aims to present thesignificance of inclusive teaching in bringing together all groups and promoting genderequality. Observational method to present effective teaching methods and strategies forinclusion was applied as research method. Moreover, the research was qualitative innature and used for explanatory research purposes. The findings indicate that inclusivelearning brings about interest and motivation to students and also promotes genderequality. Teaching inclusively also helps children to learn and develop.Keywords: Dyslexia; gender equality; inclusive teaching.
Cultural Heritage and Literature in the Face of Global Challenges
Authors: Faisal Mahmoud Adam Ibrahim
Published: January 2025

This research aims to show the importance of heritage, culture, literature and artsin the life of nations and peoples, as it represents their history, authenticity andidentity. Also, it is the thing that distinguishes the citizens of a state or people fromothers, as it is the one who puts the people or the nation in its rightful place. It isalso a tool for the formation of her thought, her mind, and her culture. In thisresearch, the researcher followed the descriptive analytical approach, which isbased on the analysis of a specific phenomenon, and suggests solutions andtreatments for it. The research concluded with the most important results:Heritage, literature and the arts have an important place in our lives, because oftheir amazing link in increasing social cohesion, and helping to promote peaceamong all, through their role in promoting trust and common knowledge.
Inner Conflict of Woman Character as Analyzed on Hayao Miyazaki’s Karigurashi no Arrietty
Authors: Khansa Zhafirah Arliyan  , Listyaningsih
Published: January 2025

Literature work as imagination and creativity, which basically can be used asentertainment and education. One of them is an anime entitled Karigurashi no Arrietty byHayao Miyazaki. This anime depicts the inner conflict of the female character caused bythe pressing circumstances both in her own environment and the external environment. Itis very suitable to be studied with the conflict theory approach of Kurt Lewin. Innerconflict is a very difficult situation for a person to make a choice. The factors that causean inner conflict, according to Lewin, include driving factors, restraining factors, factorscorresponding to a person's needs, induced factors, and impersonal factors, but theresearchers found the most inhibiting factors. There are three types of inner conflictaccording to Lewin, but in this study only type 1 conflict was used. This study usedqualitative research with descriptive methods. The result of this research is that the causeof the inner conflict is the inhibiting factor that comes from inside and outside Arrietty's
environment. At the same time, the most common form of inner conflict is approaching-away conflict, which is a form of conflict that occurs because it is faced with a difficult
choice.Keywords: Anime; Character; Inner Conflict; Kurt Lewin.
Women Mass Organizations and War in 20th Century Japan – An Overview
Authors: Susy Ong
Published: January 2025

Gender inequality is a ‘sexy topic’ for students and research on Japan in Indonesia. Many students andeven experts wonder why in such a modern and prosperous society like Japan, women lackbehind men in almost every aspect of social life, especially being excluded from social andeconomic participation. Most of the experts rationalize by pointing to ‘ryosai kenbo’ (good wife, wisemother) as cultural or traditional value that confine women in domestic sphere. In this essay, I argue,by presenting historical facts and data, that Japanese women were encouraged to and they did activelyparticipate in public sphere during the wartime in the 20th century.Keyword: women patriotic organization, women emancipation and war participation
African Fiction-African Intricacies Nexus: A Bird’s Eye View
Authors: Ayele Fafavi d’Almeida
Published: January 2025

I consider it a profound privilege and honor to be part of the remarkable ECKLL XI (11th Enrichment of Career by Knowledge of Language and Literature) event. I am delighted to share insights on “Contemporary Perspectives in Language, Literature, Education, and Culture”.
Theme of Hunger of Materialism in Tolstoy’s How Much Does a Man Need?
Authors: Cahyaningsih Pujimahanani  , Putut Handoko  , Hariyono
Published: January 2025

The research focuses on the theme of hunger of materialism in Tolstoy’s How Much Does a Man Need? The short story conveys the theme of hunger for materialism as seen how a man who a man who.is greedy with material things that he is always hungry, and he cannot satisfy his lust for it beyond limitation. Using the allusion, the researchers can learn how Tolstoy deploys the simple understanding of Bashkir, who are illiterate and seem underdeveloped people, they are much wiser than a Russian man like Pakhom. Using this technique, Tolstoy wants to say that happiness can be found ironically in the simplicity of life that does not need a lot of things that trigger the hunger of materialism that according to Christianity, he will not inherit the Kingdom of God.Keywords: Theme, hunger, allusion
Fostering Students' Curiosity through Pop Culture: Insights from English Lecturers in Indonesia
Authors: Arny Irhani Asmin  , Oikurema Purwati
Published: January 2025

Curiosity is the driving force behind learning, innovation, and human progress, while popular culture, comprising a spectrum of modern media and entertainment, is an integral part of contemporary student life. This study explores how popular culture can be used in English classrooms to spark students' curiosity. The research was a qualitative investigation involving six English lecturers in South Sulawesi, Indonesia, actively participating in focus group discussions and individual interviews. The results showed the potential of using pop culture to increase students' curiosity. The lecturers integrated various forms of pop culture in discussion activities, role-playing, voiceover exercises, storytelling sessions, vocabulary expansion exercises, dictation tasks, extensive reading, creative writing endeavors, comic and video making, vlogging, social media interactions, and interviews. The lecturers underlined that integrating popular culture into teaching practices engages, relaxes, and effectively stimulates students' curiosity. It can also foster closer relationships with students, encourage more in-depth and meaningful learning experiences, and significantly, students show enthusiasm and positive attitudes towards learning by incorporating popular culture.Keywords: curiosity, English lecturer, learning activity, pop culture
Enhancing Japanese Language Learning: The Role of Technological Tools and Supplementary Materials Among JFL Learners
Authors: Rokiah Paee
Published: January 2025

This study explores the technological tools and supplementary materials used by Japanese as a Foreign Language (JFL) learners to enhance their language learning. Interviews were conducted with 24 Malaysian undergraduate students enrolled in JFL courses, focusing on their resource preferences and learning strategies. The findings highlight significant challenges in memorizing vocabulary and Japanese characters, attributed to the high volume of required content. To address these challenges, many learners supplement traditional textbooks with digital tools such as Japanese Study, Obenkyo, and Busuu. Additionally, platforms like Google Translate and YouTube are leveraged for vocabulary practice, pronunciation guidance, and cultural immersion. Recreational digital content, such as anime and language-optioned computer games, supports informal learning by reinforcing listening and contextual understanding. Insights from this study underline the importance of integrating diverse technological tools with traditional study methods to overcome language-learning challenges.Keywords: Technological tools, supplementary materials, JFL learners, mobile applications, digital resources
The Phenomenon of Use of Chatbot Character AI by ARMY-BTS
Authors: Ninik Mardiana  , Ramaya Oktavia DA  , Selvasina Medilin K
Published: January 2025

The phenomenon of artificial characters (Character AI) has experienced development, including the need for interaction between fans and idol figures. Army as a BTS fandom also takes advantage of the availability of AI-made characters for interaction needs. The purpose of this research is to explore how Army interacts with AI characters inspired by BTS and the impact when using the application. The method used is a qualitative descriptive type, by collecting data using a questionnaire. This is of course useful for describing the phenomenon of diversity in fandom behavior towards the idol figures they idolize.Keywords: Artificial Intelegence, Army Fandom, BTS, Korean Pop
Enhanced AI-Based Navigation System for The Visually Impaired
Authors: Aniedu Azubuike Nzubechukwu , Nwokoye Sandra Chioma , Okafor Chukwunenye Sunday , Anyanwu Kingsely , Nosike Isizoh Anthony
Published: January 2025

This work introduces an Artificial intelligence (AI) based navigation system using the Raspberry Pi single-board computer. Its primary aim is to assist visually impaired users with precise navigation, achieved through machine learning algorithms for object detection. The development follows an agile methodology, emphasizing flexibility. The work explores integrating essential technologies into a system divided into two major subsystems: hardware and software. The hardware subsystem consists of a Raspberry Pi processor, a camera, an ultrasonic sensor, and a power source, collecting data on road conditions and traffic. The software employs TensorFlow and OpenCV to process data and provide optimized routes. The processed images were classified and identified using the YOLOv3 algorithm. The ultrasonic sensor could measure object distance with about 99.8% accuracy correctly. The test results demonstrate that the AI-based navigation system enhances user experiences and interaction with their environment by simplifying transportation and delivering accurate routes. It effectively analyzes and processes data obtained from the environment, improving accessibility for visually impaired individuals. The work concludes by discussing potential applications and future directions for AI-based navigation systems. It highlights the importance of affordable and accessible technology in improving transportation infrastructure, showcasing the potential for low-cost technology to enhance accessibility and mobility.
Perbandingan Berbagai Metode Pengukuran Geolistrik untuk Eksplorasi Air Tanah
Authors: Susiati Ana , Hidayatullah Didin , Hidayatulloh Mohamad Farid
Published: January 2025

Pemanfaatan air tanah sebagai sumber penyediaan air bersih untuk berbagai keperluan pada daerah limpasan menunjukkan tren yang terus meningkat, sedangkan penggunaan lahan untuk resapan juga mengalami perubahan seiring dengan berjalannya pembangunan. Untuk memenuhi kebutuhannya, banyak orang bergantung pada eksplorasi dan eksploitasi berbasis lahan. Air tanah merupakan salah satu sumber daya alam yang paling penting dan tidak dapat dipisahkan bagi kehidupan di bumi. Eksplorasi air tanah memerlukan teknik yang tepat dan efisien. Salah satu metode yang umum digunakan adalah metode resistivitas listrik karena efisien dan ekonomis dalam menentukan air tanah. Vertical Electrical Sounding (VES) Metode pengukuran resistivitas batuan dari permukaan untuk mengetahui lapisan batuan bawah permukaan. Resistivitas geolistrik merupakan salah satu variabel yang merupakan sifat fisik lapisan batuan di bawah permukaan. Data resistivitas batuan dapat digunakan untuk mengembangkan model struktur bawah permukaan dan stratigrafi ditinjau dari sifat kelistrikannya. Resistivitas geolistrik bergantung pada litologi, kandungan udara, porositas, dan konsentrasi ion pori. Metode geolistrik terbagi menjadi dua bagian yaitu metode pemetaan resistivitas sebagai metode resistivitas yang bertujuan mempelajari variasi jenis resistivitas lapisan horizontal secara horizontal dan metode sounding resistivitas atau metode resistivitas pengeboran yang mempelajari variasi resistivitas batuan di bawah permukaan bumi secara vertikal. . Pengolahan data hasil pengukuran geolistrik dapat dilakukan dengan metode kurva standar, 2- Metode Dimensi (Schlumberger dan Wenner), Metode 3 Dimensi (Konfigurasi dipol-dipol, Konfigurasi Partisi Lee, Sumber Garis Persegi Panjang, Sistem Gradien 3 Titik). Oleh karena itu, ambiguitas dalam interpretasi dapat terjadi dan menjadi sangat diperlukan untuk mengkalibrasi data pengukuran geolistrik dengan data lubang bor yang tersedia untuk menentukan kisaran resistivitas berbagai satuan litologi. Data resistivitas dapat digunakan untuk mengidentifikasi dan mendeskripsikan kondisi bawah permukaan seperti keberadaan dan jenis akuifer, air tanah yang terkontaminasi, dan distribusi ukuran sedimen.
RELEVANSI NILAI AKUNTANSI ASET TIDAK BERWUJUD PADA ERA DIGITAL
Authors: Astuti Elly , Yusdita Elana Era , Riana Ayu , Stevani Jesika , Febriani Karina Nurani
Published: January 2025

Perkembangan teknologi telah mendiversifikasi aset tak berwujud secara signifikan, yang menekankan pentingnya aset tersebut dalam pelaporan keuangan. Para pemangku kepentingan mengandalkan laporan ini untuk membuat keputusan ekonomik. Studi ini mengeksplorasi relevansi penilaian aset tak berwujud dalam transformasi digital yang berkembang pesat. Dengan menggunakan kombinasi tinjauan pustaka dan metode kuantitatif dan kualitatif, penelitian ini bertujuan untuk mendapatkan pemahaman yang komprehensif. Temuan penelitian mengungkapkan bahwa klasifikasi aset tak berwujud semakin beragam, mencakup organisasi, karyawannya, dan persepsi konsumen. Namun, investor cenderung tidak melihat pengungkapan aset tak berwujud sebagai sinyal positif untuk meningkatkan nilai perusahaan. Sebaliknya, dari perspektif konsumen dan mitra bisnis, pengembangan aplikasi yang mudah digunakan dan reputasi merek yang kuat secara signifikan meningkatkan nilai perusahaan perangkat lunak dan layanan teknologi informasi.
 
Technological developments have diversified intangible assets significantly, emphasizing their importance in financial reporting. Stakeholders rely on these reports to make economic decisions. This study explores the relevance of intangible asset valuation in the rapidly evolving digital transformation. By using a combination of literature reviews and quantitative and qualitative methods, this research aims to gain a comprehensive understanding. Research findings reveal that the classification of intangible assets is increasingly diverse, encompassing organizations, their employees, and consumer perceptions. However, investors tend not to see disclosure of intangible assets as a positive signal to increase company value. On the contrary, from the perspective of consumers and business partners, the development of easy-to-use applications and a strong brand reputation significantly increases the value of information technology software and services companies.
ANALISIS TEORI AISAS DALAM STRATEGI KOMUNIKASI PEMASARAN PADA AKUN INSTAGRAM @waturumpuk_mendak
Authors: Ningsih Riska Yulia , Mukhlisin Latutik - , Darodjah Rakhma Widya , Syarifuddin Muhammad
Published: January 2025

Wisata Alam Watu Rumpuk, yang berlokasi di desa Mendak Kabupaten Madiun, telah berkembang dari kawasan semak belukar menjadi destinasi wisata alam unggulan berkat inisiatif masyarakat dan dukungan pemerintah. Menghadapi tantangan ekonomi akibat gagal panen cengkeh, masyarakat berinovasi dengan mengubah potensi alam menjadi objek wisata. Dalam mempromosikan destinasi ini, akun Instagram @waturumpuk_mendak memainkan peran penting dalam strategi komunikasi pemasaran digital. Penelitian ini bertujuan untuk menganalisis penerapan teori AISAS (Attention, Interest, Search, Action, Share) dalam strategi pemasaran yang diterapkan pada akun Instagram tersebut. Dengan menggunakan pendekatan kualitatif deskriptif melalui wawancara, observasi, dan dokumentasi, penelitian ini mengeksplorasi bagaimana konten visual dan interaksi di media sosial berkontribusi terhadap menarik perhatian audiens, membangkitkan minat, dan mendorong kunjungan. Hasil penelitian menunjukkan bahwa penggunaan Instagram yang didukung oleh fitur-fitur seperti foto, video reels, hashtags, dan kolaborasi dengan influencer secara efektif menarik audiens, meningkatkan visibilitas, dan mendorong tindakan seperti kunjungan fisik ke lokasi wisata. Penelitian ini memberikan wawasan bagi pengelola wisata alam dalam memanfaatkan media sosial untuk promosi, serta memberikan kontribusi pada pengembangan pemasaran digital destinasi wisata berbasis media sosial.
 
Watu Rumpuk Nature Tourism, located in Mendak village, Madiun Regency, has transformed from a bushy area into a premier nature tourism destination thanks to community initiative and government support. Facing economic challenges due to clove crop failures, the community innovated by transforming natural potential into a tourist attraction. In promoting this destination, the Instagram account @waturumpuk_mendak plays an important role in the digital marketing communication strategy. This study aims to analyze the application of the AISAS (Attention, Interest, Search, Action, Share) theory in the marketing strategy implemented on the Instagram account. Using a descriptive qualitative approach through interviews, observations, and documentation, this research explores how visual content and interactions on social media contribute to attracting audience attention, generating interest, and encouraging visits. The research results show that the use of Instagram, supported by features such as photos, video reels, hashtags, and collaborations with influencers, effectively attracts audiences, increases visibility, and encourages actions such as physical visits to tourist locations. This research provides insights for nature tourism managers in utilizing social media for promotion, as well as contributing to the development of digital marketing for social media-based tourist destinations.
Methodology for determining the medical determinant of public health with the identification of medical risk factors for health disorders in otorhinolaryngology (on the example of analyzing the treatment of polyposis rhinosinusitis)
Authors:   PhD, visiting fellow, N.A. Semashko Research Institute of Public Health, Russkikh S.V. ,   teacher of National Research University Higher School of Economics,   researcher of the Research Institute of Organization of Health and Medical Management of the Department of Health in Moscow, Savlevich Е.L. ,   MD, associate professor, visiting fellow of the Moscow Regional Scientific Research Clinical Institute named after M.F. Vladimirsky, Vasilieva T.P. ,   MD, prof., director of N.A. Semachko Research Institute of Public Health, Tarasenko Е.А. ,   Candidate of Social Sciences, Associate Professor of NRU Higher School of Economics, Afanasyeva L.N. ,   MD, associate professor of M.K. Ammosov North-East Federal University, Shurupina А.V. ,   otolaryngologist of the Moscow Regional Scientific Research Clinical Institute named after M.F. Vladimirsky, Arsenina Yu.V. ,   deputy director of Volga Medical Research University of MH RF
Published: January 2025

An algorithm for assessing the professional potential of an otorhinolaryngologic based on the identification of medical risk factors in the provision of medical care to patients with rhinosinusitis has been developed. A total of 627 otorhinolaryngologic from 32 subjects of the Russian Federation were screened and the treatment of patients with polyposis rhinosinusitis was analyzed. The proposed methodological approach was successfully used to assess the knowledge and skills of physicians of other specialties and formed the basis for the methodology of studying the professional potential of physicians, for which the author's invention certificates were also obtained.
Keywords: public health, medical determinant of public health, medical personnel, human potential, professional potential, staff potential, medical risks, quality, interaction efficiency, medical effectiveness, polyposis rhinosinusitis, antibiotics, topical glucocorticosteroids, antiseptics, otorhinolaryngologic, sociological research.
Саммит Будущего и права человека.
Authors: Карташкин В.А.
Published: January 2025

Данная публикация посвящена неординарному событию глобального масштаба — Саммиту Будущего, состоявшемуся 22—23 сентября текущего года и призванному сыграть важную роль в подтверждении Устава ООН, активизации многостороннего подхода к проблемам, придании ускорения выполнению существующих обязательств, а также в согласовании конкретных решений проблем и восстановлении доверия между государствами — членами Организации. Автор делает специальный акцент на итогах Саммита в контексте осуществления и защиты прав человека, рассматривая в дискуссионном ключе спорные точки зрения на данную проблематику, содержащиеся в других публикациях.

This article is devoted to an extraordinary global event – Summit of the Future, which took place on September 22-23 this year and was called upon to play an important role in reaffirming the UN Charter, activating the multilateral approach, accelerating the implementation of existing commitments, as well as agreeing on specific solutions to problems and restoring trust between member states. The author places special emphasis on the results of the Summit in the context of the implementation and protection of human rights, examining in a discussion vein the controversial points of view on this issue contained in other publications.
К вопросу о совершенствовании правового механизма предотвращения загрязнения атмосферного воздуха
Authors: Джунусова Д.Н.
Published: January 2025

Проблема обеспечения надлежащего качественного состояния атмосферного воздуха с каждым годом приобретает все более актуальный характер. В связи с этим необходимо постоянно совершенствовать правовые основы организации охраны этого важнейшего компонента природной среды. В статье исследуются причины и факторы, способствующие ухудшению качества атмосферного воздуха, последствия его загрязнения для живых организмов, проводится анализ содержания основных нормативных правовых актов, устанавливающих обязательные требования по охране атмосферного воздуха от загрязнения.

The problem of ensuring the proper quality of atmospheric air is becoming more and more relevant every year. Therefore, it is necessary to constantly improve the legal framework for the organization of protection of this most important component of the natural environment. The article examines the causes and factors contributing to the deterioration of atmospheric air quality, the consequences of its pollution for living organisms, analyzes the content of the main normative legal acts establishing mandatory requirements for the protection of atmospheric air from pollution.
К вопросу о предмете экологического права
Authors: Куракин А.В. , Елбаева Н.А. , Козырева Ю.Н. , Калинина Ю.В.
Published: January 2025

В статье рассматривается предмет экологического права, характеризуется круг общественных отношений, связанных с экологическим правом. Отмечается, что основы данного направления правового регулирования определены в Конституции России. Приводятся различные точки зрения относительно определения предмета экологического права, а также сформулировано собственное представление о данной отрасли с учетом опыта имеющегося доктринального анализа.

The article examines the subject of environmental law, characterizes the range of public relations related to environmental law. It is noted that the foundations of this area of ​​legal regulation are defined in the Constitution of Russia. Various points of view are given regarding the definition of the subject of environmental law, and the author's own idea of ​​this branch is formulated taking into account the experience of the existing doctrinal analysis.
Роль общественного контроля в обеспечении прав и свобод человека и гражданина в Российской Федерации: перспективы развития
Authors: Ястребова А.И. , Поваров Н.А.
Published: January 2025

В статье рассматривается понятие общественного контроля, анализируются принципы и основы данной деятельности, закрепленные в законах и подзаконных актах, исследуются цели, субъекты и формы осуществления общественного контроля в России. Предложены перспективы развития общественного контроля в Российской Федерации. Делается вывод о необходимости более тесного сотрудничества государства и общества в решении различных вопросов организации и обеспечения общественной жизнедеятельности.

The article examines the concept of public control, analyzes the principles and foundations of this activity, enshrined in laws and regulations, examines the goals, subjects, and forms of implementation of public control in Russia. Prospects for the development of public control in the Russian Federation are proposed. A conclusion is made about the need for closer cooperation between the state and society in solving various issues of organizing and ensuring public life.
Защита прав кредиторов от сделок с номинальными (мнимыми) держателями активов должника
Authors: Амбарцумов Р.А.
Published: January 2025

Недобросовестные должники часто «записывают» свое имущество на других лиц — мнимых собственников. В результате такое имущество не попадает в конкурсную массу должника в случае его банкротства, и кредиторы не могут получить удовлетворение своих требований из стоимости этого имущества. Для защиты прав и законных интересов кредиторов необходимо наличие действенного механизма по возврату активов в конкурсную массу должника — реального собственника имущества. Между тем при защите кредиторами своих прав на практике часто возникают сложности, связанные с доказыванием мнимости собственника и выбором способа защиты. Автор исследует понятие мнимости собственности и способы защиты прав кредиторов от сделок с мнимыми собственниками.

Unfair debtors often "write down" their property to other persons – imaginary owners. As a result, such property is not included in the bankruptcy estate of the debtor in the event of bankruptcy and creditors are deprived of the opportunity to obtain satisfaction of their claims from the value of this property. To protect the rights and legitimate interests of creditors, it is necessary to have an effective mechanism for the return of assets to the bankruptcy estate of the debtor – the real owner of the property. Meanwhile, in practice, when creditors protect their rights, difficulties often arise related to proving the imaginary owner and choosing a method of protection. This paper examines the concepts of imaginary property and ways to protect creditors' rights from transactions with imaginary owners.
Конституционное регулирование брачно-семейных отношений в Республике Беларусь
Authors: Шупицкая О.Н.
Published: January 2025

Брачно-семейные отношения — сфера общественных связей, в которых сочетается как частноправовое, так и публично-правовое регулирование. Брак как союз мужчины и женщины, семья являются основными институтами гражданского общества, находящимися одновременно и под пристальным вниманием государства. Брачно-семейные отношения в Беларуси регулируются, с одной стороны, нормами обычаев и традиций, а с другой — нормативными актами государства, среди которое важнейшее значение имеет Конституция Республики Беларусь. Цель исследования — проанализировать конституционное регулирование брачно-семейных отношений в условиях белорусской национальной правовой системы через призму обычаев, конституционно-правовых принципов и конституционно-правовых норм; выявить тенденции, связанные с указанным регулированием. По мнению автора, при сохранении в целом диспозитивного характера воздействия на сферу брака и семьи со стороны белорусских государственных институтов возрастает число императивных предписаний, позволяющих в определенной мере контролировать эту сферу.

Marital and family relations are a sphere of social relations, which combine both private and public legal regulation. Marriage as a union of a man and a woman, family are the main institutions of civil society, which are simultaneously under close attention of the state. Marital and family relations in Belarus are regulated, on the one hand, by the norms of customs and traditions, and, on the other hand, by regulatory acts of the state, among which the Constitution of the country is the most important. The purpose of the study is to analyze the constitutional regulation of marital and family relations in the context of the Belarusian national legal system through the prism of customs and constitutional legal principles and constitutional legal norms; to identify trends associated with this regulation. According to the author, while maintaining the generally optional nature of the impact on the sphere of marriage and family on the part of Belarusian state institutions, the number of imperative regulations is increasing, allowing marriage and family to be to a certain extent controlled.
Evaluating the Diversity and Target Addressability of DELs using Scaffold Analysis and Machine Learning
Authors: Fischer Yaelle , Cedeno Ruel , Triki Dhoha , Vivet Bertrand , Schambel Philippe
Published: January 2025

DNA-encoded libraries (DELs) enable efficient experimental screening of vast combinatorial molecular libraries, making it a powerful platform for drug discovery. Apart from ensuring the druglike physicochemical properties, other key parameters to maximize the success rate of DEL designs include the scaffold diversity and target addressability. While several computational tools have been developed to evaluate DEL chemical diversity, a dedicated tool that combines both parameters is currently lacking. In this work, we developed a computational approach to systematically evaluate both the scaffold diversity and target-orientedness of DELs using Bemis-Murcko (BM) scaffold analysis and machine learning. To demonstrate its utility, we present a case study using two of our in-house produced libraries. We show that our workflow can effectively distinguish between a generalist and a focused library. Furthermore, we show that although focused libraries tend to have higher compound-based addressability, they could suffer from lower scaffold-based addressability relative to a generalist library. Consequently, we illustrate how our tool can guide medicinal chemists in deciding which library to screen as a function of the objective, whether it is hit-finding or hit-optimization. To facilitate utilization, this tool is freely available both as a web application and as a Python script at https://github.com/novalixofficial/NovaWebApp.
Structural Elucidation of Na2/3NiO2, A Dynamically Stabilised Cathode Phase with Ni Charge- and Na Vacancy- Ordering
Authors: Steele James Mark Alexander , Genreith-Schriever Annalena R , Bocarsly Joshua D , Nagle-Cocco Liam Agostino Vincenzo , Sayed Farheen N , Juramy Marie , O'Keefe Christopher A , Orlandi Fabio , Manuel Pascal , Dutton Siân E , Grey Clare P
Published: January 2025

NaNiO2 (NNO) has been investigated as a promising sodium-ion battery (NIB) cathode material, but it is limited by degradation-induced capacity fade. On desodiation, NNO forms multiple phases with large superstructures due in part to Na+-ion vacancy ordering, however, their structures are unknown. Here, we report a structural solution to the Na2/3NiO2 (P/3) de-sodiated phase using combined Rietveld refinement of high-resolution synchrotron X-ray (SXRD) and neutron diffraction (NPD) data, magnetic susceptibility, and 23Na solid-state nuclear magnetic resonance (ssNMR) spectroscopy. Our experimental results are compared to Ab Initio Molecular Dynamics (AIMD) simulations, which indicate multiple low-energy structures that are dynamically populated. We observe a combination of competing effects which contribute to the resultant dynamic nature of the structure, including honeycomb ordering of mixed-valence Ni, orbital-ordering of Jahn-Teller (JT) distorted Ni3+, and zigzag Na+/vacancy ordering. Our work provides evidence of the multiple contributions to the structures of de-sodiated Na2/3NiO2, along with a framework for investigating the other unsolved de-sodiated structures. This work may also inform understanding of the Jahn-Teller evolution in other nickel-rich lithium and sodium ion cathodes, such as LiNiO2.
Donor-Acceptor Index as a Descriptor for Electrolyte Design in High-Voltage Aqueous Batteries
Authors: Hou Chuanyu , Xie Miao , Wang Jianhui
Published: January 2025

Introducing organic molecules to anchor water can reduce water activity and expand the electrochemical stability window of aqueous electrolytes. However, there is a lack of reliable guidelines for screening suitable organic modulators. Through examining the effects of various organic molecules on the hydrogen bonding network of water, we found that the water-anchoring capabilities of organic modulators are positively correlated with their acceptor-donor index (IA-D)—the sum of the products of donor and acceptor sites and their respective intensities. Furthermore, lithium metal titration-assisted differential electrochemical mass spectrometry (Li-DEMS) technique was developed to systematically investigate the charge-discharge behavior of three electrodes with different redox potentials (Li4Ti5O12, V2O5, and Zn) in nonaqueous/aqueous hybrid electrolytes containing different organic modulators and salts. The contributions of the hydrogen evolution reaction (HER) and solid-electrolyte interphase (SEI) formation to irreversible capacity were decoupled. For all the electrodes studied, a higher IA-D value correlates with a smaller contribution of HER to irreversible capacities and higher initial and average Coulombic efficiencies. Notably, HER becomes the dominant contributor to irreversible capacity after the initial cycles. For the high-potential electrode (V2O5), electrochemical performance is primarily influenced by IA-D, rather than SEI formation, while for the low-potential electrode (Li4Ti5O12), both IA-D and SEI formation play significant roles in determining performance. These findings not only validate IA-D as a reliable descriptor for assessing the water-anchoring capabilities of organic modulators, but also establish a link between organic modulators, electrolyte solution structure, interphase reactions, and battery performances, providing valuable insights for the development of high-performance aqueous batteries.
Scalable synthesis of CO2-selective porous single-layer graphene membranes
Authors: Hao Jian , Mieczyslaw Gebolis Piotr , Marcin Gach Piotr , Chevalier Mojtaba , Sébastien Bondaz Luc , Kocaman Ceren , Hsu Kuang-Jung , Bhorkar Kapil , Babu Deepu , Agrawal Kumar Varoon
Published: January 2025

Membranes based on atom-thin, porous single-layer graphene (PG) have shown attractive performance for diverse separation applications, especially gas separation and carbon capture. However, despite a decade of research, a scalable synthesis of PG membranes has remained under question. This is mainly because the literature resorts to complicated and expensive methods that yield small membranes and limited reproducibility. Herein, we introduce several interventions that significantly reduce PG membrane cost, allow uniform pore formation in a large area, and enable the preparation of large-area PG membranes with attractive performance. We show that mass transfer of the oxidant, neglected in the literature, plays a crucial role in achieving uniform oxidation of large-area graphene. Crack formation during the transfer of graphene, a major challenge in this field that also limits reproducibility, is eliminated using a novel protocol that does not require delicate floating and handling of graphene, allowing the realization of a high-performance 50 cm2 graphene membrane in a cross-flow module.