bluuebunny/crossref_metadata_2025 huggingface dataset:
Engaging Stakeholders in the Adaptation of the Connect for Health Pediatric Weight Management Program for National Implementation
Authors: Simione Meg , Frost Holly M. , Cournoyer Rachel , Mini Fernanda Neri , Cassidy Jackie , Craddock Cassie , Moreland Jennifer , Wallace Jessica , Metlay Joshua , Kistin Caroline J. , Sease Kerry , Hambidge Simon J. , Taveras Elsie M.
Published: January 2020

Background: Connect for Health is an evidence-based weight management program with clinical- and family-facing components for delivery in pediatric primary care for families of children ages 2 to 12 years. We used the Consolidated Framework for Implementation Research (CFIR) to guide formative work prior to national implementation. The purpose of this study was to describe the process and results of stakeholder engagement and program adaptation. Methods: We used mixed qualitative and quantitative methods to iteratively adapt and optimize the program by assessing needs and perspectives of clinicians and parents, as well as contextual barriers, facilitators and organizational readiness for the uptake of the proposed program tools and implementation strategies. We conducted interviews with primary care clinicians from four health care organizations in Boston, MA, Denver, CO, and Greenville, SC and used principles of immersion-crystallization for qualitative analyses. We also conducted surveys of parents of children with a body mass index ≥ 85th percentile.Results: We reached thematic saturation after 52 clinician interviews. Emergent themes representing the CFIR domains of intervention characteristics, outer and inner setting, and process included: (1) importance of evidence-based clinical decision support tools that integrate into the workflow and do not extend visit time; (2) developing resources that respond to family’s needs; (3) using multimodal delivery options for family resources; (4) addressing childhood obesity while balancing competing demands; (5) emphasizing patient care rather than documentation and establishing sustainability plans; and (6) offering multiple training methods that incorporate performance feedback. Of the parents surveyed (n=400), approximately 50% were Spanish-speaking and over 75% reported an annual income < $50,000. Parents affirmed the importance of addressing weight management during well-child visits, being provided with referrals and resources, and offering multiple methods for resource delivery. Decisions about program modifications were made at the program and healthcare-system level and based on stakeholder engagement findings. Modifications included cultural, geographic, and target audience adaptations, as well as varied resource delivery options. Conclusions: To ensure the fit between the Connect for Health program and national implementation settings, adaptations were systematically made through engagement of clinician and parent stakeholders to support adoption, sustainability, and health outcomes.
Explaining the mixed findings of a randomised trial of telehealth with centralised remote support for heart failure: qualitative evaluation
Authors: Papoutsi Chrysanthi , A'Court Christine , Wherton Joseph , Shaw Sara , Greenhalgh Trisha
Published: January 2020

BackgroundCentralised specialist remote support, in which a clinician responds promptly to biomarker changes, could potentially improve outcomes in heart failure. The SUPPORT-HF2 trial compared telehealth technology alone with the same technology combined with centralised remote support. The intervention was implemented differently in different sites; no significant impact was found overall. We sought to explain these findings in a qualitative evaluation. Methods51 people (25 patients, 3 carers, 18 clinicians and 4 additional research staff) were interviewed and observed in 7 SUPPORT-HF sites across UK between 2016 and 2018. We also collected 110 pages of documents. Analysis was informed by sociotechnical theory. ResultsPatients’ experiences of the technology were largely positive; staff engaged with the intervention to a variable degree. Existing services, staffing levels, technical capacity and previous experience with telehealth all influenced how the complex intervention of ‘telehealth technology plus centralised specialist remote support’ was interpreted and the extent to which it was adopted and used to its full potential. In some settings, the intervention was quickly mobilised to fill significant gaps in service provision. In others, it was seen as usefully extending the existing care model for selected patients. However, in some settings, the new care model was actively resisted and the technology little used. In one setting, centralised provision of specialist advice aligned awkwardly with an existing community-based heart failure support service. ConclusionsThe introduction of a telehealth programme rests not only on the technological intervention but also on the individuals involved and numerous subtle aspects of local service design. An iterative approach that attends to patients’ illness experiences, clinicians’ professional values, work practices and care pathways could lead to more effective telehealth support for patients with heart failure.
An intelligent decision-making support system for the detection and staging of prostate cancer in developing countries
Authors: Zhang Jun , Chen Zhigang , Wu Jia , Liu Kanghuai
Published: January 2020

Background Most developing countries face great problems in the medical, and the threat posed by large populations, scarce medical resources and inadequate medical personnel will affect the development and stability of the society. Therefore, for most developing countries, the development of intelligent medical systems can greatly alleviate the social contradictions arising from this problem. Intelligent Medical System is a system to assist doctors to make decisions. Through effective input, the system makes corresponding decisions and provides doctors with corresponding auxiliary diagnosis and relevant treatment plans. Methods The experimental team collected and compiled about 2,156,528 data items based on the hospitalization information of more than 8,000 prostate patients in three hospitals of Xiangya. The ratio of experimental data to test data was about 7: 3. Combining prostate cancer images and physical indicators to assist diagnosis and make decisions, from the extraction of corresponding image feature data to the final diagnosis decision, a new intelligent system for prostate cancer data decision-making based on Perceptron neural network is proposed. In the comprehensive decision-making, the final decision is made by using the rule-reasoning model. Through data collection, medical data analysis and integration, image processing and analysis, and disease detection and decision-making processes, patients are assisted in diagnosis and treatment to solve the problems and social contradictions facing most developing countries. Results Through the study of hospitalization information of more than 8,000 prostate patients in three hospitals, about 2,156,528 data items were collected and compiled for experiment purposes. Experimental data shows that when the patient base increases from 200 to 8,000, the accuracy of the machine-assisted diagnostic system will increase from 61% to 87%, and the doctor's diagnosis rate will be reduced to 81%. Conclusions From the study, it is concluded that when the patient base reaches a certain number, the diagnostic accuracy of the machine-assisted diagnosis system will exceed the doctor's expertise. So the smart medical system can help doctors and Medical experts make suggest more effective treatments.
Socioeconomic status and health literacy as the important predictors of general health in Iran: A structural equation modeling approach
Authors: Nadi Taiebeh , Poorolajal Jalal , Doosti-Irani Amin
Published: January 2020

Background: We aimed to determine the level of health literacy (HL), and its association with general health. In addition, we investigated the direct and indirect association of socioeconomic status (SES) and general health among the adult population in Iran. Methods: This cross-sectional study involved 750 literate adults' people. The SES was assessed based on the owning of assets HL was evaluated using a validated questionnaire in Iran. General health was assessed using the WHO general health questionnaire. The simple and adjusted linear regression models, and structural equation modeling (SEM) were used for data analysis. Results: In adjusted model, female gender, higher level of education, use of books, pamphlets, or brochures as a source of health information, the higher level of SES was positively associated with higher HL. In addition, the HL was significantly associated with higher scores of general health. Results of SEM showed that the direct effect of SES on general health was not significant, but the indirect effect via HL was significant (path coefficient: 0.24; p<0.001). Conclusion: Results of our study indicated HL is strongly associated with general health among the adult population. SES had a significant indirect association with general health via the effect on health literacy.
Sex-specific Longitudinal Comparison of CES-D and PHQ-9 Depression Scales. A Concordance Analysis using data from the population-based Heinz Nixdorf Recall Study
Authors: Engel Miriam , Peternel Markus , Jöckel Karl-Heinz , Schramm Sara , Slomiany Uta , Moebus Susanne
Published: January 2020

Background To measure depressive symptoms in population-based studies, there are two well-established questionnaires: the Center for Epidemiologic Studies Depression Scale (CES-D) and the Patient Health Questionnaire-9 (PHQ-9). So far, comparisons between both instruments have only been performed using cross-sectional data, and in specific patient groups. Furthermore, comparisons for population-based studies are missing as well as sex-specific analyses. The aim is to evaluate the psychometric properties and concordance of the longitudinal results of CES-D and PHQ-9 in the German population-based Heinz Nixdorf Recall (HNR) study. Methods We used data of n=3,084 participants (48.8% men, mean age: 66.8 years). CES-D and PHQ-9 were assessed in the 8th (t8) and 9th (t9) annual postal follow up within two years via questionnaires. Depressive symptoms were defined as CES-D score ≥ 17 and PHQ-9 score ≥ 10. Internal consistency reliability, convergent validity, and agreement between PHQ-9 and CES-D were assessed using respectively Cronbach’s alpha, Pearson’s correlation, and Cohen’s kappa. To analyse depressive symptoms differences between t8 and t9 we used McNemar’s test. Sex-stratified results are presented. Results The prevalence of depressive symptoms at t8 was higher for CES-D (7.8%) than for PHQ-9 (4.4%). The prevalence slightly increased for CES-D (8.1%), as well as for PHQ-9 to 4.5% at t9. Internal consistency of the PHQ-9 and CES-D was good at both times (Cronbach’s alpha: CES-D t8 & t9: 0.89, PHQ-9 t8: 0.84; t9: 0.85). Cohen’s kappa of agreement between CES-D and PHQ-9 was moderate at both time points (t8: k=0.57; 95% CI: 0.51, 0.63; t9; k=0.58; 95% CI: 0.52, 0.64). For both instruments, the McNemar’s test revealed no differences in the proportion of depressives between t8 and t9. We could not observe sex-specific differences of psychometric characteristics, whereas the agreement between the CES-D and PHQ-9 performed slightly higher in men than in women (t8: k=0.61, resp. k=0.55). Conclusions The results do not support the superiority of one of the scales. Both scales perform well in this population-based cohort in both sexes and longitudinal approach. The decision, which scale to use may depend on characteristics other than the accuracy of the scale, including feasibility and clinical usability.
Value Co-creation and Leadership: An Analysis Based on the Business Ecosystem Concept
Authors: Bonamigo A. , Mendes D.
Published: January 2020

This paper summarizes the arguments and counterarguments of the scientific discussion on multi-company co-operation leading, given that co-creating value between companies is a survival strategy for organizations by boosting competitiveness jointly several players. However, in the literature, the empirical characterization of value creation management in service companies is little explored. Therefore, the main objective of the research is to list the key factors for managing value co-creation in an industrial service company. To achieve this goal, an on-site interview was conducted with the leaders of a business-consulting firm whose business strategy is to cooperate with multiple players. The company object of research is located in southern Brazil, in the state of Santa Catarina. Once data collection was conducted, then content analysis was conducted. Based on the research findings, eleven key criteria that characterize cooperation between companies in the business consulting area were listed. It was found that value co-creation had several advantages for the company studied, however, lack of trust is one of the critical and risk factors for cooperation with other companies. Thus, it can be seen that leadership strategies are a key element for meeting potential business partners to co-create value as well as for managing cooperation between multiple companies. Given the findings, some practical implications can be highlighted. The study can serve as a basis for managers and leaders to make strategic business decisions, guide business leadership in driving plans to capture new business partners reliably and that together can generate mutual value. In addition, it is clear that the studied company’s system in relation to knowledge management is fragile since there is no structured system to control and disseminate knowledge internally and externally to the analyzed company. Thus, this research allows us to identify new insights to advance in studies related to the leadership of value co-creation among companies.
Keywords: Leadership, Value co-creation; Business consulting; Multi-agent cooperation; Innovation; Industrial service management.
Research on Multi - Resonant LCL Harmonic Suppression Strategy
Authors: Chen Jingwen , Zhou Xin , Dang Hongshe
Published: January 2020

Aiming at the resonance problem in the process of grid connection of LCL filter microgrid inverter, a multi-resonance LCL harmonic suppression strategy is proposed. On the basis of analyzing the principle and establishing the mathematical model in detail, the realization process of the multi-resonance constant power compound control strategy is studied emphatically. Through the simulation, the validity of the control strategy is verified, The results show that the scheme stabilizes the output power and reduces the total harmonic distortion of the grid-connected inverter to 0.12%, and the corresponding phase current distortion rate drops to 0.02%.The suppression effect is obvious, it is an effective harmonic suppression method.
Analysis and Design of Image Segmentation Algorithm Based on Super-pixel and Graph Cut
Authors: Xiao Feng , Sun Hao
Published: January 2020

Image segmentation has always been a research hotspot in computer vision. Traditional image segmentation is based on pixels, and it is difficult to achieve the desired target effect. The manual segmentation method is too cumbersome and has limited precision. There is a certain degree of instability in the selection of interactively segmented pixels, which will affect the final segmentation results to a large extent.

In this paper, the superpixel block generated by the SLIC algorithm is used to preprocess the image, and then based on the Graph cut algorithm, the selection of seed points is improved, and the pixels of the background area are attempted to be optimized to obtain a more excellent target point sample. On top of the image segmentation, the foreground object is further divided with a frame, the pixels in the background are optimized, and the advantages of other segmentation algorithms are extracted to achieve the goal of global optimization, and interactive image segmentation is achieved.
Numerical simulation of scour and flow field over movable bed induced by a submerged wall jet
Authors: Samma Hamidreza , Khosrojerdi Amir , Rostam-Abadi Masoumeh , Mehraein Mojtaba , Cataño-Lopera Yovanni
Published: January 2020

Dam construction continues its rapid expansion around the world primarily for the purpose of hydropower generation. One important consequence of such projects is local scour at the downstream of the dam caused by outflow of excess reservoir water through spillways or bottom outlets that is associated with high velocities. The scour development endangers the dam foundation and river banks and undermines the stability of the hydraulic structures. In this study, a detailed three-dimensional (3D) flow simulation is conducted to investigate the complex fluid–sediment interactions leading to the formation of the scour hole and ridge systems downstream of a near-bottom jet. Three different bed-load equations, including Meyer-Peter–Müller, Nielsen, and Van Rijn formulas, are applied for calculating the bed-load transport rate. Comparison with a series of available experimental data shows that the Meyer-Peter–Müller equation results in better predictions than the two other relations. The performance of different turbulence models to reproduce vertical profiles of velocity and scour characteristic against the experimental data were evaluated. The vertical and horizontal profiles of the scour hole-ridge system are also compared with the corresponding experimental ones. The numerical model satisfactorily reproduces the geometric parameters representing the scour hole. However, the model overestimates the length of the scour hole.
Developing a sustainable biosolids program through a comprehensive, collaborative approach for Arlington county
Authors: Tsang K. Richard , Strawn Mary , Broderick Tom , Treadway Jonathan
Published: January 2020

Arlington County, Virginia has recently completed a wastewater solids master plan addressing the near- and long- term needs of the County's biosolids program. The planning process included comprehensive evaluation of over 70 technologies. The project team included representatives from engineering, operations, maintenance, and management from the County; a consultant team of national and local experts; a technical expert advisory committee from consultants, utilities, and academia; and community stakeholders. There were multiple project team workshops and regular presentations to stakeholders, feedback from which was incorporated into the planning process. Ultimately, there was a detailed evaluation of four process options – lime-stabilization (the current process), mesophilic anaerobic digestion, thermal hydrolysis pre-treatment leading to anaerobic digestion, and anaerobic digestion with thermal drying. The four options were evaluated against nineteen criteria representing economic, operating, environmental, and social issues of the ‘quadruple bottom line.’ The County has now developed a more sustainable biosolids program plan that includes the development of anaerobic digestion with thermal hydrolysis pre-treatment to produce a commercially viable biosolids product. The process will also produce biogas for use as fuel. The collaborative approach, which included evaluating numerous options and engaging with many stakeholders, contributed to the project's success and has provided a resilient roadmap towards a more sustainable biosolids program.
Exciting Potential of Nanoparticlized Lipidic System for Effective Treatment of Breast Cancer and Clinical Updates: A Translational Prospective
Authors: Harwansh Ranjit K. , Bahadur Shiv , Deshmukh Rohitas , Rahman Md. A.
Published: January 2020

:

Breast cancer (BC) is a multifactorial disease and becoming a major health issue in women throughout
the globe. BC is a malignant type of cancer which results from transcriptional changes in proteins and genes.
Besides the availability of modern medicines and detection tools, BC has become a topmost deadly disease and its
cure still remains challenging. Nanotechnology based approaches are being employed for the diagnosis and
treatment of BC at clinical stages. Nanosystems have a significant role in the study of the interaction of malignant
cells with their microenvironment through receptor-based targeted approach. Nowadays, lipid-based nanocarriers
are being popularized in the domain of pharmaceutical and medical biology for cancer therapy. Lipidic nanoparticlized
systems (LNPs) have proven to have high loading efficiency, less toxicity, improved therapeutic efficacy,
enhanced bioavailability and stability of the bioactive compounds compared to traditional drug delivery systems.
In the present context, several LNPs based formulations have been undertaken in various phases of clinical trials
in different countries. This review highlights the importance of chemotherapeutics based lipidic nanocarriers and
their anticipated use for the treatment of BC. Furthermore, the clinical trials and future prospective of LNPs have
been widely elaborated.
Synthesis, Cytotoxicity and Docking Simulation of Novel Annulated Dihydroisoquinoline Heterocycles
Authors: Saleh Fatma M. , Hassaneen Hamdi M. , Mohamed Magda F. , Mohamed Yasmin Sh.
Published: January 2020

Objective:

Coupling of ethyl 2-(6,7-dimethoxy-3,4-dihydroisoquinolin-1-yl)acetate 2 with
diazotized anilines in ethanol in the presence of sodium acetate yielded 2-(2-arylhydrazono)-2-(6,7-
dimethoxy-3,4-dihydroisoquinolin-1-yl)acetate (4a-f).

Methods:

Treatment of 2 with α-bromoketones 6a-f in dry benzene at reflux gave the corresponding
isoquinolinium bromides 7a-f. Refluxing of each of the salts 7a-f in dry benzene and in the presence of
triethylamine yielded 2-arylpyrrolo-[2,1-a]isoquinoline structures 8a-f, that converted to ethyl (E)-8,9-
dimethoxy-3-(phenyldiazen-yl)-2-(aryl)-5,6-dihydropyrrolo[2,1-a]isoquinoline-1-carboxylate (9a-f)
upon treatment with diazotized anilines 3 in ethanol in the presence of sodium acetate.

Results and Conclusion:

Cytotoxic assay was performed for in vitro antitumor screening against caucasian
breast adenocarcinoma (MCF7), hepatocellular carcinoma (HepG2) and colorectal carcinoma
(HCT-116) cell lines. The results were compared with the standard anticancer drug (doxorubicin). Molecular
docking using MOE 2014.09 software was carried out for the most potent compound 4d, which
showed the highest binding affinity towards the four tested proteins and thus initiated apoptosis of cancer
cells.
Neuroserpin in Bipolar Disorder
Authors: Çinar Rugül Köse
Published: January 2020

Objective:

Neuroserpin is a serine protease inhibitor predominantly expressed in the nervous
system functioning mainly in neuronal migration and axonal growth. Neuroprotective effects of neuroserpin
were shown in animal models of stroke, brain, and spinal cord injury. Postmortem studies confirmed
the involvement of neuroserpin in Alzheimer’s disease. Since altered adult neurogenesis was postulated
as an aetiological mechanism for bipolar disorder, the possible effect of neuroserpin gene expression
in the disorder was evaluated.

Methods:

Neuroserpin mRNA expression levels were examined in the peripheral blood of bipolar disorder
type I manic and euthymic patients and healthy controls using the polymerase chain reaction
method. The sample comprised of 60 physically healthy, middle-aged men as participants who had no
substance use disorder.

Results:

The gene expression levels of neuroserpin were found lower in the bipolar disorder patients
than the healthy controls (p=0.000). The neuroserpin levels did not differ between mania and euthymia
(both 96% down-regulated compared to the controls).

Conclusion:

Since we detected differences between the patients and the controls, not the disease states,
the dysregulation in the neuroserpin gene could be interpreted as a result of the disease itself.
Antenatal Depression; its Prevalence of Positive Screen and the Associating Risk Factors Including Labor and Neonatal Outcome
Authors: Elias Nurezwana , Sulaiman Sofiah
Published: January 2020

Background:

Antenatal depression is often neglected and unrecognized. It is known to
be associated with various unwanted outcomes for both mothers and babies.

Objective:

This study aims to assess the prevalence of a positive screen for antenatal depression and
its risk factors as well as the labour and neonatal outcomes.

Method:

265 pregnant women who received care from University Malaya Medical Centre were
recruited in this study. They completed the Edinburgh Postnatal Depression Scale (EPDS) questionnaires
twice; once during the antenatal period and once again during the postnatal period. Only
235 out of 265 data were analysed for the association between risk factors, labour and neonatal
outcome. Postnatal data that were collected after 4-6 weeks of delivery were completed in 90
women.

Results:

41 women (17%) were found to have a positive screen and it has a significant positive
correlation with postnatal EDPS score (r=0.919, p=0.00). After adjustment for confounders, preexisting
medical illness is the only risk factor found to be associated with the positive screen group
(OR 3.0, 95% CI1.11-8.46). The positive screen group is also associated with reduced neonatal
birth weight (0R=0.998; 95%CI0.997-0.999), reduced cord pH (OR=0.000; 95%CI0.000-0.202) and
increased blood loss at birth (0R=1.005; 95%CI1.001-1.009).

Conclusions:

The positive screen group of antenatal depression is associated with few adverse pregnancy
and neonatal outcomes. Therefore, a formal mental health assessment should be offered to all
pregnant women who are found to have a positive screen of antenatal depression.
Design, Synthesis, Docking and Biological Evaluation of Novel 4-hydroxy Coumarin Derivatives
Authors: Ramalakshmi N. , Chitra S.R. , Manimegalai P. , Arunkumar S.
Published: January 2020

Background:

Hospital acquired (HA) infections are caused due to E. coliwhich is resistant to multiple drugs particularly to fluroquinolone class of drugs. Urinary tract infections (UTI) affects people in the community and in hospitals. 150 million people per annum are suffering from UTI worldwide.

Methods:

: In this present study, we designed 36 novel coumarin derivatives, also we predicted
pharmacokinetic and toxicity parameters. Docking studies were also carried out and all the compounds
were evaluated for antibacterial activity against resistant quinolone E. coli strain ATCC
25922. It was interesting to note that the introduction of electron-withdrawing group on the aromatic
ring resulted in compounds with an increased antibacterial activity, which is observed in
compound 6 (with 4-nitro substitution), compound 23 (chloro) and compound 30 (chloro, nitro).

Results:

From the MIC results, it was observed that compounds 6, 23 and 30 showed higher activity
with 0.5μg/ml, 0. 12 μg/ml, 0.5 μg/ml respectively. Docking studies were performed with the
active site of DNA gyrase (PDB ID: 4CKK). The maximum binding energy was found to be -10.7
Kcal/mol.

Conclusion:

From the study, it was found that 3 compounds were potentially active against quinolone-
resistant E. coli strains. This study can further be extended for in vivo evaluation.
Current Nanotechnology Based Solutions for Sustainable Wastewater Treatment
Authors: Murshid Shabnam , Gopinath Kannappan Panchamoorthy , Prakash Dhakshinamoorthy Gnana
Published: January 2020

Background:

Industrialization plays an important role in the growth of a nation. But it is
also one of the causes of the deteriorating condition of our ecosystem. The pollution, be it aquatic,
terrestrial, or air-borne, has affected our environment drastically, and industrial and domestic
wastewater plays a major role in it. As the Earth transforms into urban sprawl, industries flourish,
pollution increases and the natural resources deplete. Recently nano-engineering based technologies
have been explored for the purpose of wastewater treatment, which helps in the detection and
remediation of the pollutants present in wastewater. Various nano-material based technologies
deployed in wastewater treatment are discussed in this article.

Methods:

A thorough survey of the literature was effectuated, and the study was focused mainly on
the different types of nanomaterials applied for the purpose of wastewater management and the
diverse treatment methods related to them. Literature was also studied to confirm the
functionalization of nanomaterials as pollution sensors.

Results:

There are four main kinds of nano-materials employed for the purpose of wastewater
remediation, i.e. metallic nanomaterials, carbon-based nanomaterials, nanocomposites, and
dendrimers. The treatment technologies utilizing these materials include nanofiltration, nanoadsorption,
nano-photocatalysis, and disinfection.

Conclusion:

Nanomaterials are quite efficient in removing pollutants from different kinds of
wastewater. But drawbacks such as expenditure and effect of the materials in the environment make
it difficult for real-time utilization. Since the nano-scaled elements behave differently than their
standard-sized counterparts, the consequence of these materials in the human life cycle is unknown.
This knowledge gap should be filled so that these materials can be adopted worldwide.
Synthesis, Biological and Computational Evaluation of Novel 2,3-dihydro-2-aryl-4-(4- isobutylphenyl)-1,5-benzothiazepine Derivatives as Anticancer and Anti-EGFR Tyrosine Kinase Agents
Authors: Shaik Afzal B. , Prasad Yejella R. , Nissankararao Srinath , Shahanaaz Shaik
Published: January 2020

Background:

Despite the availability of a variety of chemotherapeutic agents, cancer is still one of
the leading causes of death worldwide because of the problems with existing chemotherapeutic agents like objectionable
side effects, lack of selectivity, and resistance. Hence, there is an urgent need for the development of
novel anticancer agents with high usefulness, fewer side effects, devoid of resistance and superior selectivity.

Objective:

The objective of this study is to synthesize a series of novel 1,5-benzothiazepine derivatives and
evaluate their anticancer activity employing biological and computational methods.

Methods:

Twenty new benzothiazepines (BT1-BT20) were prepared by condensing different 1-(4-
isobutylphenyl)ethanone chalcones with 2-amiothiophenol and evaluated for their anticancer activity by MTT
assay against three cell lines including HT-29 (colon cancer), MCF-7 (breast cancer) and DU-145 (prostate
cancer). These compounds were also tested for their inhibitory action against EGFR (Epidermal Growth Factor
Receptor) tyrosine kinase enzyme by taking into account of their excellent action against colon and breast cancer
cell lines. Further, the structural features responsible for the activity were identified by Pharmacophorebased
modelling using Schrodinger’s PHASETM software.

Results:

Among the 20 benzothiazepine derivatives, three compounds viz., BT18, BT19 and BT20 exhibited promising
activity against the cell lines tested and the activity of BT20 was more than the standard methotrexate. Again the
above three compounds showed excellent inhibitory activity with the percentage inhibition of 64.5, 57.3 and
55.8 respectively against EGFR (Epidermal Growth Factor Receptor) tyrosine kinase. PHASE identified a five-point
AHHRR model for the proposed activity and the computational studies provided insights into the structural
requirements for the anticancer activity and the results were consistent with the observed in vitro activity data.

Conclusion:

These novel benzothiazepines will be useful as lead molecules for the further development of new
cancer therapies against colon and breast cancers.
PSİKOLOJİK DANIŞMAN ADAYLARININ MESLEĞE İLİŞKİN KİŞİSEL EĞİLİMLERİ
Authors: Korkut Owen Fidan , Tuzgöl Dost Meliha
Published: January 2020

Bu çalışmanın amacı lisans düzeyindeki
psikolojik danışman adaylarının cinsiyetlerine, sınıflarına, psikolojik danışma
eğitimini seçme nedenlerine ve alanının neden önemli olduğuna yönelik
görüşlerine göre mesleğe ilişkin kişisel eğilimlerinin değişip değişmediğini
ortaya koymaktır. Çalışmanın katılımcıları İç Anadolu Bölgesi’ndeki büyük bir
şehirde bulunan iki devlet üniversitesindeki toplam 431 Psikolojik Danışma ve
Rehberlik programı öğrencisidir. Veriler Mesleğe İlişkin Kişisel Eğilimleri
Değerlendirme Ölçeği ve Kişisel Bilgi Formu ile toplanmıştır. Elde edilen
bulgulara göre, kadın psikolojik danışman adaylarının ölçeğin  toplam ve tüm altı alt boyutlardan elde
ettikleri puanların erkek psikolojik danışman adaylarına göre daha yüksek
olduğu görülmektedir. Sınıf düzeyi psikolojik danışman adaylarının kişilerarası
ilişkilere özen ve kendinin farkında olma alt boyutlarından elde ettikleri
puanların arttığı saptanmıştır. Psikolojik danışma alanını planlayarak
seçenlerin mesleğe ilişkin kişisel eğilimlerinin diğer nedenlerle seçenlere
göre daha yüksek olduğu elde edilen bulgulardandır. Benzer biçimde psikolojik
danışma alanını başkalarına yardımcı olduğu için önemli bulanların mesleğe
ilişkin kişisel eğilimleri de diğer görüşlerde olan gruplara göre daha yüksek
bulunmuştur. Bulgular alanyazın ışığında tartışılmış ve gelecek araştırmalar ve
uygulamalar için öneriler sunulmuştur.
Avaliação da independência das agências reguladoras dos setores de energia elétrica, telecomunicações e petróleo no Brasil
Authors: De Souza Vieira José Nilton , Corrêa Gomes Ricardo , Guarido Filho Edson Ronaldo
Published: January 2020

Este artigo propõe novos parâmetros e indicadores para avaliar os níveis de independência formal e de facto dos órgãos reguladores. O alvo são as agências dos setores de eletricidade, telecomunicações e petróleo no Brasil. O estudo é orientado por duas perspectivas teóricas: a da necessidade de independência dos órgãos reguladores, uma vez que a interferência política pode elevar os riscos e inibir o investimento privado, especialmente nos setores de infraestrutura; e a da influência das instituições, presentes em cada setor e em cada país, sobre os novos desenhos institucionais. Trata-se de uma pesquisa descritiva, que identificou diferenças nos desenhos institucionais, não captadas por metodologias convencionais, como o índice de governança regulatória, proposto pelo Banco Mundial. Os resultados confirmam a maior resistência às mudanças nos setores de energia: menor independência formal das agências reguladoras e presença mais ativa das autoridades políticas no campo normativo desses setores. Além disso, os índices estimados confirmam que as três agências não dispõem de autonomia para gerir as próprias receitas. Essa limitação à independência de facto ocorre principalmente na fase de elaboração da proposta orçamentária.
Strength Properties of Untreated Coal Bottom Ash as Cement Replacement
Authors: Baco Noraziela Syahira , Shahidan Shahiron , Zuki Sharifah Salwa Mohd , Ali Noorwirdawati , Azmi Mohamad Azim Mohammad
Published: January 2020

Coal Bottom Ash (CBA) is a mineral by-product of thermal power plants obtained from the combustion of coal. In many countries, CBA wastes are identified as hazardous materials. The utilization of CBA can help in alleviating environmental problems; thus, this research was carried out to explore the possibility of its use as cement replacement in concrete manufacturing. Presently, In Malaysia, research that concerns about the use of CBA as cement replacement is very limited. Therefore, this study was aimed to investigate the properties of CBA as cement replacement and to identify the optimum percentage of untreated CBA as cement replacement. The CBA used in this study were taken from the Tanjung Bin power plant. In this research, the amount of CBA in the concrete mixture varied from 20% to 40% to replace cement. The properties of concrete containing CBA as cement replacement was examined through slump test, sieve analysis, concrete compressive strength test and splitting tensile strength test. The compressive strength test and splitting tensile strength test were performed at 7 and 28 days of curing time. Based on this research, it can be concluded that the optimum percentage of CBA as cement replacement is 25% for a curing time of both 7 and 28 days with the concrete compression strength of 45.2 MPa and 54.6 MPa, respectively. Besides, the optimum percentage for tensile strength is also at 25% CBA for a curing period of both 7 and 28 days with the tensile strength of 2.91 MPa and 3.28 MPa, respectively.
A Critical Review of Wastewater Resource Recovery Implementation in Indonesia
Authors: Marleni Ni Nyoman Nepi , Raspati Gema Sakti
Published: January 2020

Wastewater has been recognized as a resource due to its large quantities, and it contains many valuable resources that can be converted into valuable material. Reusing or recovering resources from wastewater can reduce the environmental footprint of wastewater treatment, minimize the contamination and ensure the availability of valuable resources for the human being. The ultimate aim of wastewater resource recovery (WRR) is to create a sustainable and resilient community which is very relevant in Indonesia as this country experiences many natural or human-made disaster. To have an effective implementation, therefore, it is crucial to identify the barriers or supporting factors in its implementation of Wastewater Resource Recovery, which can be different for many regions. Through extensive literature studies, this study intends to review the possibility of WRR implementation in Indonesia.  This study discusses Indonesia policy/regulation about wastewater management across all-region in Indonesia, identify barriers in WRR, compares global trends of wastewater management to Indonesia practice and list wastewater resources that potentially can be recovered in Indonesia. From the review, barriers of WRR implementation in Indonesia is most probably due to the policy and regulation of wastewater management which many of them did not support the option of WRR, instead of suggesting only safe discharge option. However, some regulations have mentioned the utilization of wastewater by-product, but it is limited only to treated water utilization. Other obstacles are social acceptance and distance between recovered material supply and demand. Social acceptance includes the human perception regarding the health risk associated with wastewater by-product. Religion also could be a potential barrier that needs to be handled in the implementation of WRR. This study could give new insight into the current state of wastewater resource recovery initiative in Indonesia; thus the strategy to overcome the barriers could be designed.
Ethnicity Situation and Intolerant Attitudes in Multicultural Societies in the Medan City
Authors: Damanik Erond Litno
Published: January 2020

This article aims to explore and discuss the phenomenon of intolerant attitudes in multicultural societies. Empirically, the substance of the study is focused on strengthening discrimination and segregation in Medan City. The fundamental problem is formulated in the question: is it true that intolerant attitudes have an impact on discrimination and segregation in multicultural societies? This study was conducted qualitatively with a descriptive approach. Data collected through in-depth interviews and questionnaires. Theoretically, the reference used is the Least-Liked approach developed by Sullivan. Data analysis refers to eight attribute values tolerant according to Ingelhart. The study’s finding is that the Least-Liked attitude is the failure of an assimilationist political mechanism. Multiculturalism is influenced by ethnicity situations that do not guarantee the emergence of multiculturalist attitudes but have the least related effects, discrimination, and segregation. The novelty of this study lies in the idea of multiculturalism which is lacking in the support of assimilative politics. Theoretically, the contribution of this study reinforces Sullivan’s assumptions and empirically emphasizes the importance of assimilative political mechanisms in multicultural societies.
Discursive Construction of Subject and Ideological Fantasy in Postcolonial Indonesia
Authors: Salam Aprinus
Published: January 2020

This paper tries to explain the contestation at the discursive construction level of the subject. The subject in question is Indonesia in postcolonial era. The problem that will be answered was how the ideological fantasy constructed its subject. The data were chosen purposively from several novels. The paper approach is discourse-like in nature. The results of this paper show that in the contestation there is competition of colonial discourse, modernism; in which will also crossed with religion or local values. It can be concluded that there has been overlapping ideological fantasy of Indonesian postcolonial subject.
The End of Peasantry: Peasants and Cities in Colonial Java in The Early Twentieth Century
Authors: Akhyat Arif -
Published: January 2020

This paper aims to explain the decline of the peasant community in Semarang City, Central Java, by exploring the historical shifts in the city's spatial structures and livelihoods. Spatial changes and the issue of subsistence ethics simultaneously will be used to explain the peasant community’s exclusion in the city. In the early of modernization Semarang, peasant economy collapsed by deagrarianization process and  creating patterns of domestication, adaptation, and marginalization. This adaptation was necessary to reaffirm longstanding communal bonds that had contributed significantly to the city's historical growth. At the same time, however, the urban peasant community was excluded, as agrarian subsistence ethics required it to remain subordinate, while the city's new economic system limited or failed their social mobility. As a result, the peasant community was increasingly left behind by the city's social transformation. Discussing the end of the peasantry during decolonialization process is as a way to find out the consolidation ability of the peasant community during a depeasantization process.  This paper will answer the question how socio-economic modifications were made by peasant to navigate with gigantic changes in the city during decolonialization Semarang? Using the historical method, an analysis of a peasant community seems to be more appropriate for obtaining the process of ending of the peasantry and it took into account for both the continuity and the discontinuity process. This paper is expected to provide new facts that have implications for the writing of the Javanese urban historiography which has never been present in Indonesian historiography.
Differences in effectiveness of membrane fixation using periosteal vertical mattress and simple sling suture techniques in infrabony pocket treatment
Authors: Oktiani Beta Widya , Lastianny Sri Pramestri , Syaify Ahmad
Published: January 2020

Guide tissue regeneration (GTR) is the treatment of infrabony pockets for soft and hard tissue regeneration. Membrane is used as a barrier and prevents apical migration of the cells in epithelial tissues. Membrane fixation is one of the procedures in GTR treatment because resorbed membrane is less stable. Simple sling suture technique for membrane fixation has 1 anchorage, located in coronal flap, while periosteal vertical mattress suture technique has 2 anchorages in periosteum, making it more stable. This study aimed to study the differences in the effectiveness of membrane fixation using periosteal vertical mattress suture and simple sling suture techniques in terms of probing depth, relative attachment loss, and alveolar bone height in the treatment of infrabony pockets. The samples were divided into 2 groups. The first group was open flap debridement (OFD) with demineralized freeze dried bone allograft (DFDBA) application and membrane fixation with simple sling suture, while the second group was OFD with DFDBA application and membrane fixation with periosteal vertical mattress suture, observed on day 0, 30th day, and 90th day. The results of the study showed significant differences in the probing depth and relative attachment loss (except from the 30th day to the 90th day), and there were no significant differences in the alveolar bone height from the baseline to the 90th day, between the group of membrane fixation using simple sling suture and that of periosteal vertical mattress suture techniques on flap surgery. This study concluded that membrane fixation in the treatment of infrabony pocket with periosteal vertical mattress suture technique is more effective in reducing the probing depth and relative attachment loss, but there is no difference in increasing the alveolar bone height when compared to simple sling suture technique.
KINEMATIC MODELING OF THE TECHNIQUE STALDER BACKWARD TO HANDSTAND ON THE UNEVEN BARS
Authors: Petković Emilija
Published: January 2020

Optimizing the technique of successful performance is important for detecting different technique styles that occur in female gymnasts. The aims of this research were to define an optimal kinematic model of the Stalder backward to handstand on the uneven bars exercise, as well as factors that most greatly affect the successful performance of the selected exercise, performed at the 39th and 40th World Cups in Artistic Gymnastics in Maribor (SLO). The sample of participants consisted of eight female gymnasts who participated in the Finals and performed the above mentioned exercise. Kinematic parameters were determined by the use of the Ariel Performance APAS 3-D video system, and anthropometric 16 reference points with four body segments (foot, center of gravity of the body-CG, shoulder joint and head). CG was calculated based on the model presented by Winter in 2009. The results of the research defined the kinematic exercise model that requires four phases: 1) Upswing from a handstand position to balance the resistance front; 2) Downswing to upswing with clear support; 3) Lower vertical passing; 4) Swing to handstand position. Variability of the trajectory of referent points is necessary as an indication of the successful performance of the Stalder backward to handstand on the uneven bars technique. In the current research, the variability for the successful technique for CG trajectory values decreases from -0.767m to -1.045m, while the trajectory values of the shoulder point decrease from 0.689m to 0.488m under the axis of rotation. The information given could optimize the performance of other young gymnasts at all levels of performance.
Nuevos registros de tayra (Eira barbara) y ocelote (Leopardus pardalis) en una selva baja caducifolia de Yucatán, México.
Authors: Hernández-Hernández Julio C. , Monter-Pozos Alvaro , Villegas-Patraca Rafael
Published: January 2020

ResumenEl tayra (Eira barbara) y el ocelote (Leopardus pardalis) son dos especies que se encuentran catalogadas en peligro de extinción. En este trabajo presentamos nuevos registros de ambas especies en la región litoral centro del estado de Yucatán, México. Nuestras observaciones se basan en registros obtenidos mediante cámaras trampa colocadas en fragmentos de vegetación secundaria de selva baja caducifolia (SBC) con cierto grado de perturbación. Obtuvimos dos registros de tayra, en uno de ellos se aprecian dos individuos y seis fotografías de ocelote. Estos registros muestran la importancia de los manchones de sbc como potenciales refugios, corredores biológicos o sitios de paso para las especies silvestres.Palabras clave: Cámaras-trampa, Carnívora, nuevos registros, Yucatán.AbstractThe tayra (Eira barbara) and ocelot (Leopardus pardalis) are species that are cataloged in danger of extinction. In this work we present new records of both species in the central coastal region of Yucatan state, Mexico. Our observations are based on records using camera traps, placed in fragments of secondary vegetation in tropical dry forest (TDF) with some degree of disturbance. We obtained two records of tayra, one of them shows two individuals, in addition to six photographs of ocelot. These records denote the importance of tdf patches as potential shelters, biological corridors or wildlife passage sites.Key words: Camera-trapping, Carnivore, new records, Yucatan.
О методике оценки критических определителей в рамках вопроса оценки константы совместных диофантовых приближений
Authors: Басалов Юрий Александрович
Published: January 2020

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О некоторых характерах представлений групп
Authors: Малинин Дмитрий
Published: January 2020

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