bluuebunny/crossref_metadata_2025 huggingface dataset:
Design and Flight Simulation Verification of the Dragonfly eVTOL Aircraft
Authors: Zhao Wen , Wang Yingqi , Li Liqiao , Huang Fenghua , Zhan Hanwen , Fu Yiqi , Song Yunfei
Published: July 2024

Recently, electric vertical take-off and landing (eVTOL) aircraft have become a top priority for urban air transportation due to their ability to overcome urban ground traffic congestion. In this research, a new type of scaled lift–cruise ‘Dragonfly’ has been designed. The ‘Dragonfly’ combines the characteristics of an octocopter and a fixed-wing aircraft. Compared with the same type of eVTOL aircraft, it has a longer wingspan and a more stable aircraft structure, it can not only take off and land vertically without the need for a runway, but also fly quickly in a straight line and hover in mid-air. In order to ensure the success of the flight test, it was also simulated in this paper. A simulation scenario highly fitting with the flight test environment of eVTOL is designed in the Gazebo simulation platform, and then combined with the PX4 flight control platform, the system SITL of the constructed aircraft simulation model is carried out on the Gazebo platform, Finally, simulation flight test data for accurate analysis are obtained, the accuracy and stability of the control algorithm are fed back, and scientific support for the follow-up ‘Dragonfly’ aircraft hardware-in-the-loop simulation and physical flight test is provided.
Cardiopulmonary Resuscitation Training and Automatic External Defibrillators Deployment: Strengthening Community Response to Cardiac Arrest
Authors: Giamello Jacopo Davide , Barile Chiara , Flego Lorella , Lauria Giuseppe , Silimbri Luigi , Garrone Simona , Nannini Marco , Melchio Remo , Racca Emanuela , Aimar Beatrice , Gallo Marco , Bertolaccini Luca
Published: July 2024

The most effective strategy to save the life of a victim of out-of-hospital cardiac arrest (OHCA) is to provide aid as early as possible. To achieve this objective, widespread dissemination of knowledge on basic life support and defibrillation (BLSD) in the general population is necessary. In recent years, evidence has been emerging supporting the effectiveness of public-access defibrillation (PAD) programs; the diffusion of automatic external defibrillators (AEDs) and the knowledge of their correct use among lay rescuers are associated with a higher survival rate and better neurological outcomes among OHCA victims. This study aims to implement and monitor a BLSD training program involving an entire city in Italy. Since 2016, a PAD program has been implemented in Busca (CN), a small town in the northwest of Italy. The project was divided into three phases: (1) the diffusion of AEDs in the most-frequented places in the city; (2) BLSD training aimed at reaching the most significant possible number of citizens; (3) the training of all schoolchildren in the basics of first aid. The retention of the concepts learned was assessed via a multiple-choice questionnaire proposed months after the training events. From 2016 to 2023, 42 BLSD courses were held, which trained 1302 adults (12.8% of citizens) with a female/male ratio of 0.9 and a median age of 46 (range: 32–59 years). The participants in the courses were volunteers from associations (59%), athletes (16%), ordinary citizens (13%), school staff (10%), and municipal employees (2%). At the start of the project in 2016, the first 11 AEDs were positioned. To date, the municipal area can count on 25 always-available defibrillators to reach each area within 4 minutes. Furthermore, 1500 school pupils were trained. The retention of the learned notions was excellent. After training, 92% of adult participants and 90% of the schoolchildren reported being willing to provide help in the event of cardiac arrest. The project combined the widespread diffusion of AEDs with a significant number of citizens able to use them, effectively providing cardiopulmonary resuscitation. This project ensured that an entire community shared the goal of saving the lives of people affected by OHCA.
The Effect of a SEL (Social–Emotional Learning) Intervention Program Based on Emotional Regulation and Metacognitive Awareness for Special Education Preservice Teachers Experiencing Adapted Teaching in Mathematics
Authors: Gidalevich Stella , Mirkin Ella
Published: July 2024

This study’s aim was to examine the influence of a unique intervention program based on emotional self-awareness and the development of emotional regulation as an important component of SEL combined with metacognitive awareness. Seventy-two third-year preservice teachers participated for one year, tutoring a mathematically challenged student. This intervention was applied to an experimental group where each participant learned to assess his/her emotional state using a special ruler prior to teaching a lesson, and according to the ruler’s assessment results, the preservice teacher was assisted by a variety of emotional regulations as well as metacognitive strategies. A control group learned only metacognitive strategies. This study’s results indicated that experimental group participants showed notable improvement in cognitive reappraisal post-intervention compared to the control group, which showed no change. For metacognitive awareness, in both research groups, an increase was apparent post-intervention. Nevertheless, a comparison of the effect size of differences between the two measurement points indicated that the experimental group exhibited a greater improvement in metacognitive regulation compared to the control group. A significant positive correlation was found in the experimental group between cognitive reappraisal and metacognitive regulation. Assimilation and training of emotional skills among preservice teachers during training are necessary.
Simple Sugars Alter the Odorant Composition of Dairy Cow Manure
Authors: Loughrin John , Agga Getahun , Lovanh Nanh
Published: July 2024

A study was conducted to determine if the odor profile of Bos taurus manure could be altered by the addition of the simple saccharides glucose, lactose, and sucrose. Sucrose was added to manure slurry at 0, 12.5, 25, 50, or 125 g L−1, while glucose and lactose were added at 0, 6.45, 13.2, 26.4, or 65.8 g L−1. One hundred mL slurries were incubated in capped bottles at 30 °C for four weeks. Biogas production was measured throughout the incubations, and the pH and concentrations of short-chain fatty acids were measured at the end of the incubations. Odor compounds of the final manure slurries were isolated by stir bar sorptive extraction and identified by stir bar gas chromatography/mass spectroscopy. Unamended manure had high concentrations of the typical manure malodorants phenol, p-cresol, p-ethylphenol, indole, and skatole. The addition of the sugars decreased these malodors in a dose-dependent manner. The addition of sugars shifted odor production to aliphatic esters including ethyl butyrate and propyl propanoate. The sugar-amended manure therefore had a different odor profile than the unamended manure did. The addition of sugar also caused the accumulation of short-chain fatty acids and, thus, decreased the pH of the manure. The production of lactic acid was particularly enhanced at high concentrations of sugar, suggesting that lactic acid bacteria could be responsible for changes in the odor profile. Future research will investigate if the addition of lesser concentrations of sugars or agricultural and food wastes rich in carbohydrates can reduce manure malodor.
Reshaping Emergency Care: Dynamics of OHCA and STEMI in a Three-Year Analysis
Authors: Bottega Francesca , Kacerik Erika , Perotti Gabriele , Signorelli Carlo , Ristagno Giuseppe
Published: July 2024

The COVID-19 pandemic drastically reshaped healthcare in Lombardy, Italy, notably impacting EMS and emergency departments and altering the epidemiology of time-dependent pathologies such as STEMI and OHCA. While previous studies focused on modifications during the pandemic peak, with an increase in the number of OHCA diagnoses and a reduction in the number of STEMI, little evidence exists regarding the inter-pandemic phases. We analyzed OHCA and STEMI accesses to the ED in the regional emergency department access register (EUOL) for 2019–2021. The analysis revealed a significant difference in monthly diagnosis averages. For STEMI, the change was statistically significant (F(2, 33) = 4.45, p = 0.02), while it was not for OHCA (F(2, 33) = 0.18, p = 0.83). Despite the monthly decreases, the likelihood of receiving a STEMI diagnosis increased with total accesses, OR 1.40 [95% CI 1.25–1.58, p < 0.0001]. Additionally, there was a significant increase in March 2020 discharge diagnoses for OHCA compared to March 2019, OR 3.35 [95% CI 2.88–3.90, p < 0.0001], corresponding to the first pandemic wave. Therefore, our analysis indicates that the epidemiology of STEMI and OHCA was altered during the COVID-19 pandemic.
Charring of and Chemical Changes in Historical Wood under Thermal Loading
Authors: Dúbravská Katarína , Kučerová Viera , Štefková Jaroslava , Mišíková Ol’ga
Published: July 2024

Research in historical timber assessment is hindered by the limited availability of samples, yet understanding the fire resistance of historic wood is crucial for preservation efforts. There is an opinion that historic wood behaves similarly to contemporary wood in terms of fire resistance. The aim of this paper is to observe the rate of charring of historical pine wood during the experiment, the color changes in the sample that occurred due to thermal loading, and the changes in the chemical composition of pine wood. Test samples made from historic pine wood were loaded with a 50 kW∙m−2 radiation panel for 60 min. The charring process was faster at the beginning of the charred layer formation. The charring rate at the beginning of the test at a depth of 10 mm from the exposed side reached values from 1.28 mm∙min−1 to 3.16 mm∙min−1. At a depth of 30 mm from the exposed side, the individual charring rates approached a value of 1 mm∙min−1 (0.99 mm∙min−1 to 1.08 mm∙min−1). Observations during medium-scale testing revealed distinct layers forming on the exposed side: a charred layer, charring base, pyrolysis layer, and intact wood. The chemical composition of the wood changed under the influence of the thermal load. The relative contents of extractives and holocellulose decreased with the increasing temperature while the lignin content increased. The highest value of combustion heat was measured in the charred layer of the sample. Correlation analysis demonstrated a negative relationship between the combustion heat and holocellulose, while a positive correlation was found with the lignin content. Chemical changes were also monitored using the FTIR method. These findings provide valuable insights into the behavior of historic pine wood under thermal loading, which is essential for understanding and preserving historical structures.
Natural Fiber-Reinforced Mycelium Composite for Innovative and Sustainable Construction Materials
Authors: Voutetaki Maristella E. , Mpalaskas Anastasios C.
Published: July 2024

Fiber-reinforced mycelium (FRM) composites offer an innovative and sustainable approach to construction materials for architectural structures. Mycelium, the root structure of fungi, can be combined with various natural fibers (NF) to create a strong and lightweight material with environmental benefits. Incorporating NF like hemp, jute, or bamboo into the mycelium matrix enhances mechanical properties. This combination results in a composite that boasts enhanced strength, flexibility, and durability. Natural FRM composites offer sustainability through the utilization of agricultural waste, reducing the carbon footprint compared to conventional construction materials. Additionally, the lightweight yet strong nature of the resulting material makes it versatile for various construction applications, while its inherent insulation properties contribute to improved energy efficiency in buildings. Developing and adopting natural FRM composites showcases a promising step towards sustainable and eco-friendly construction materials. Ongoing research and collaboration between scientists, engineers, and the construction industry will likely lead to further improvements and expanded applications. This article provides a comprehensive analysis of the current research and applications of natural FRM composites for innovative and sustainable construction materials. Additionally, the paper reviews the mechanical properties and potential impacts of these natural FRM composites in the context of sustainable architectural construction practices. Recently, the applicability of mycelium-based materials has extended beyond their original domains of biology and mycology to architecture.
Effect of Surfactants on the Synthesis and Dissociation of Gas Hydrates
Authors: Misyura Sergey , Morozov Vladimir , Strizhak Pavel , Shlegel Nikita , Donskoy Igor
Published: July 2024

The synthesis and dissociation of methane hydrate and carbon dioxide hydrate were studied. Nonflammable gas hydrates can be used to extinguish flames in confined spaces. To increase the extinguishing efficiency, it is necessary to increase the dissociation rate (gas release rate) by using surfactant. The work investigates gas hydrates synthesized using sodium dodecyl sulfate (SDS). Experimental studies were carried out in wide ranges of surfactant concentration, the number of the stirrer revolutions and the initial water volume. To achieve the maximum rate of synthesis and dissociation, optimization of the specified parameters was performed. The influence of the key parameters on the dissociation rate was investigated experimentally and theoretically. The novelty of the work lies in solving a complex of interrelated tasks on the synthesis and dissociation of gas hydrate. It is shown that in order to achieve the maximum dissociation rate of carbon dioxide hydrate, it is necessary to optimize the following parameters: the diameter of the particles and their porosity, the porosity of the layer and the external heat flux.
Ingredient Functionality of Soy, Chickpea, and Pea Protein before and after Dry Heat Pretreatment and Low Moisture Extrusion
Authors: Pennells Jordan , Trigona Louise , Patel Hetvi , Ying Danyang
Published: July 2024

This study investigates the impact of dry heat pretreatment on the functionality of soy, chickpea, and pea protein ingredients for use in texturized vegetable protein (TVP) production via low moisture extrusion. The protein powders were heat-treated at temperatures ranging from 80 °C to 160 °C to modulate the extent of protein denaturation and assess their effects on RVA pasting behavior, water absorption capacity (WAC), and color attributes. The results indicate that the pretreatment temperature significantly influenced the proteins’ functional properties, with an optimal temperature of 120 °C enhancing pasting properties and maintaining WAC, while a higher pretreatment temperature of 160 °C led to diminished ingredient functionality. Different protein sources exhibited distinct responses to heat pretreatment. The subsequent extrusion processing revealed significant changes in extrudate density and color, with increased density and darkness observed at higher pretreatment temperatures. This research provides insights into the interplay between protein sources, pretreatment conditions, and extrusion outcomes, highlighting the importance of controlled protein denaturation for developing high-quality, plant-based meat analogues. The findings have broad implications for the optimization of meat analogue manufacturing, with the aim of enhancing the sensory experience and sustainability of plant-based foods.
Analysis of the Sensory Profile and Physical and Physicochemical Characteristics of Amazonian Cocoa (Theobroma cacao L.) Beans Produced in Different Regions
Authors: dos Santos Renato Meireles , Silva Niara Maria de Jesus , Moura Fábio Gomes , Lourenço Lúcia de Fátima Henriques , Souza Jesus Nazareno Silva de , Sousa de Lima Consuelo Lúcia
Published: July 2024

The cocoa tree (Theobroma cacao L.) has seeds that after processing become a valuable agricultural commodity in the world. In Brazil, the state of Pará located in the Eastern Amazon is the main producer, accounting for more than 53% of the national production. Although the region is the largest producer, no studies are found in the literature containing data on the sensory quality of the beans. Thus, the purpose of this study is to establish the sensory profile of Amazonian cocoa from the main cocoa-producing regions of the Eastern Amazon (Lower Tocantins River, Northeast, West, Southeast and Trans-Amazon). The sensory profile was established from the Quantitative Descriptive Analysis (QDA), in addition to using an affective test to verify consumer preference for the chocolates produced. Physical, physicochemical and bioactive compound evaluations were carried out. Beans from different regions had a similar sensory profile; however, it was possible to observe some differences in certain descriptor terms. In the physical evaluation, the samples presented an acceptable commercial standard, and the humidity was within the values established by the legislation. It was found that the post-harvest and/or processing parameters had no influence on the quality attributes of cocoa beans.
Extraction Effects on Roselle Functionalities: Antioxidant, Antiglycation, and Antibacterial Capacities
Authors: Lai Ying-Jang , Chiang Yi-Chan , Jhan Yi-Syuan , Song Tuzz-Ying , Cheng Ming-Ching
Published: July 2024

This study investigated the effects of certain roselle (Hibiscus sabdariffa Linnaeus) extraction methods on various functional properties, including the antioxidant and antiglycation capacities and bacterial growth inhibition. Roselle anthocyanins were extracted using water and ethanol solvents at different temperatures and concentrations. The results revealed that the extraction rate increased with higher temperatures and ethanol concentrations (p < 0.05). Ethanol extracts exhibited higher total organic acid and total anthocyanin contents compared to water extracts, while water extracts showed higher total saccharide, total polyphenol, and total flavonoid contents (p < 0.05). Furthermore, the water extracts demonstrated superior Trolox equivalent antioxidant capacity (TEAC) values, while the ethanol extracts exhibited better 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging ability, antiglycation capacity, and bacterial growth inhibition. A Pearson correlation analysis revealed strong associations between specific components and functional properties, such as a positive correlation between the total anthocyanin content and antiglycation capacity (R2 = 0.9862). A principal component analysis and agglomerative hierarchical clustering highlighted distinct clusters of water and ethanol extracts, indicating solvent-dependent variations in functional properties. This study assessed roselle extraction models for antioxidant, antiglycation, and antibacterial activities, which could be used for the development of functional alcoholic or non-alcoholic beverages.
R&D Expenditures and Analysts’ Earnings Forecasts
Authors: Elkemali Taoufik
Published: July 2024

Previous research provides conflicting results regarding how R&D expenditures impact market value. Given that financial analysts are the primary intermediaries between companies and investors, our study focused on the impact of R&D-related uncertainty, growth, and information asymmetry associated on analysts’ earnings forecasts. Based on 19,834 firm-year observations in the European market between 2005 and 2020, our results show that R&D activities lead to higher absolute forecast error and negative forecast error, indicating higher forecast inaccuracy with an optimistic bias. Additionally, these investments contribute to higher forecast dispersion, indicating disagreement among financial analysts. The comparison between 17 industries revealed that these effects are more pronounced in R&D-intensive industries than in non-R&D industries, uncovering the varied relationship between R&D investments and analyst forecasts across sectors.
The Influence of Sulfation Degree of Glycosaminoglycan-Functionalized 3D Collagen I Networks on Cytokine Profiles of In Vitro Macrophage–Fibroblast Cocultures
Authors: Ullm Franziska , Renner Alexander , Freudenberg Uwe , Werner Carsten , Pompe Tilo
Published: July 2024

Cell–cell interactions between fibroblasts and immune cells, like macrophages, are influenced by interaction with the surrounding extracellular matrix during wound healing. In vitro hydrogel models that mimic and modulate these interactions, especially of soluble mediators like cytokines, may allow for a more detailed investigation of immunomodulatory processes. In the present study, a biomimetic extracellular matrix model based on fibrillar 3D collagen I networks with a functionalization with heparin or 6-ON-desulfated heparin, as mimics of naturally occurring heparan sulfate, was developed to modulate cytokine binding effects with the hydrogel matrix. The constitution and microstructure of the collagen I network were found to be stable throughout the 7-day culture period. A coculture study of primary human fibroblasts/myofibroblasts and M-CSF-stimulated macrophages was used to show its applicability to simulate processes of progressed wound healing. The quantification of secreted cytokines (IL-8, IL-10, IL-6, FGF-2) in the cell culture supernatant demonstrated the differential impact of glycosaminoglycan functionalization of the collagen I network. Most prominently, IL-6 and FGF-2 were shown to be regulated by the cell culture condition and network constitution, indicating changes in paracrine and autocrine cell–cell communication of the fibroblast–macrophage coculture. From this perspective, we consider our newly established in vitro hydrogel model suitable for mechanistic coculture analyses of primary human cells to unravel the role of extracellular matrix factors in key events of tissue regeneration and beyond.
Genome-Wide Identification and Evolutionary and Mutational Analysis of the Bos taurus Pax Gene Family
Authors: Zhong Jintao , Wang Wenliang , Li Yifei , Wei Jia , Cui Shuangshuang , Song Ning , Zhang Yunhai , Liu Hongyu
Published: July 2024

Bos taurus is known for its tolerance of coarse grains, adaptability, high temperature, humidity, and disease resistance. Primarily, cattle are raised for their meat and milk, and pinpointing genes associated with traits relevant to meat production can enhance their overall productivity. The aim of this study was to identify the genome, analyze the evolution, and explore the function of the Pax gene family in B. taurus to provide a new molecular target for breeding in meat-quality-trait cattle. In this study, 44 Pax genes were identified from the genome database of five species using bioinformatics technology, indicating that the genetic relationships of bovids were similar. The Pax3 and Pax7 protein sequences of the five animals were highly consistent. In general, the Pax gene of the buffalo corresponds to the domestic cattle. In summary, there are differences in affinity between the Pax family genes of buffalo and domestic cattle in the Pax1/9, Pax2/5/8, Pax3/7, and Pax4/6 subfamilies. We believe that Pax1/9 has an effect on the growth traits of buffalo and domestic cattle. The Pax3/7 gene is conserved in the evolution of buffalo and domestic animals and may be a key gene regulating the growth of B. taurus. The Pax2/5/8 subfamily affects coat color, reproductive performance, and milk production performance in cattle. The Pax4/6 subfamily had an effect on the milk fat percentage of B. taurus. The results provide a theoretical basis for understanding the evolutionary, structural, and functional characteristics of the Pax family members of B. taurus and for molecular genetics and the breeding of meat-production B. taurus species.
Alpine Catchments’ Hazard Related to Subaerial Sediment Gravity Flows Estimated on Dominant Lithology and Outcropping Bedrock Percentage
Authors: Tiranti Davide
Published: July 2024

Sediment gravity flows (SGFs) cause serious damage in the Alpine regions. In the literature, several methodologies have been elaborated to define the main features of these phenomena, mainly considering the rheological features of the flow processes by laboratory experiments or by flow simulation using 2D or 3D propagation models or considering a single aspect, such as the morphometric parameters of catchments in which SGFs occur. These very targeted approaches are primarily linked to the definition of SGFs’ propagation behavior or to identify the predisposing role played by just one feature of catchments neglecting other complementary aspects regarding phenomena and the environment in which SGFs can occur. Although the research aimed at the quantification of some parameters that drive the behavior of SGFs provides good results in understanding the flow mechanisms, it does not provide an exhaustive understanding of the overall nature of these phenomena, including their trigger conditions and a complete view of predisposing factors that contribute to their generation. This paper presents a research work based on the collection and cross-analysis of lithological, geomechanical, geomorphological and morphometrical characteristics of Alpine catchments compared with sedimentological and morphological features of SGF deposits, also taking in to account the rainfall data correlation with historical SGF events. A multidisciplinary approach was implemented, aiming at quantifying SGF causes and characteristics starting from the catchments’ features where the phenomena originate in a more exhaustive way. The study used 78 well-documented catchments of Susa Valley (Western Italian Alps), having 614 historical flow events reported, that present a great variability in geomorphological and geological features. As the main result, three catchment groups were recognized based on the dominant catchment bedrock’s lithology characteristics that influence the SGFs’ rheology, sedimentological and depositional features, triggering rainfall values, seasonality, occurrence frequency and alluvial fan architecture. The classification method was also compared with the catchments’ morphometry classification, demonstrating that the fundamental role in determining the type of flow process that can most likely occur in a given catchment is played by the bedrock outcropping percentage, regardless of the results provided by the morphometric approach. The analysis of SGF events through the proposed method led to a relative estimate of the hazard degree of these phenomena distinguished by catchment type.
Goal-Directed Use of Prothrombin Complex Concentrates in Liver Transplantation: Is a Plasma-Free Procedure Feasible?
Authors: Punzo Giovanni , Di Franco Valeria , Aceto Paola
Published: July 2024

Background: Fresh frozen plasma (FFP) transfusions have been the mainstay of hemostatic intervention for the treatment of bleeding and coagulation abnormalities arising during liver transplantation (LT) for decades. However, numerous clinical studies showed that FFP has many side effects, including the risk of pathogen transmission, transfusion-associated circulatory overload (TACO), transfusion-related immunomodulation (TRIM), and transfusion-related acute lung injury (TRALI). These adverse events are particularly challenging in patients undergoing LT, who often suffer from severe portal hypertension, poor renal function and coexisting cardiac disease.The aims of this review are to summarize the pharmacological properties of currently available PCCs, to represent the theoretical benefits and the possible risks related to the use of these drugs in patients undergoing LT, and, finally, to review the current literature on the topic in order to highlight the evidence that currently supports PCC use in LT patients. Methods: The current literature on the topic was reviewed in order to highlight the evidence that currently supports PCC use in LT patients. Results: Prothrombin complex concentrates (PCCs) may offer several advantages when compared to FFP. Indeed, PCCs have been shown to reduce the risk of TACO, which during liver transplantation may deteriorate portal hypertension, increase intraoperative bleeding, and possibly reduce survival rates. One of the major concerns for PCC use is thrombogenicity. However, currently available PCCs are much safer as they contain inactivated forms of the vitamin K-dependent coagulation factors and protein C, protein S, antithrombin and/or heparin. Nowadays, the use of PCCs to correct coagulation abnormalities that occur during LT is an increasingly widespread practice. However, it is not yet clear what level of evidence supports this practice, and what the risks associated with it are. Conclusions: Administration of PCC in LT patients to correct haemostatic abnormalities seems to be well-tolerated, but the relationship between PCC use and thromboembolic events in the postoperative period remains unclear. Adequately powered, methodologically sound trials are urgently required for more definitive conclusions about the efficacy and safety of PCCs in a broad phenotype of LT recipients.
Generative Artificial Intelligence, Human Agency and the Future of Cultural Heritage
Authors: Spennemann Dirk H. R.
Published: July 2024

The first half of 2023 was dominated by a public discussion of the nature and implications of generative artificial intelligence (genAI) models that are poised to become the most significant cross-cultural global disruptor since the invention of the World-Wide Web. It can be predicted that genAI will affect how cultural heritage is being managed and practiced, primarily by providing analysis and decision-making tools, but also by genAI generated texts and images, in particular reconstructions of objects and sites. The more speculative interpretations of contexts and alternative interpretations generated by genAI models may constitute manifestations of cultural heritage in their own right. But do these constitute human cultural heritage, or are they AI cultural heritage? This paper is a deliberation of the realities and future(s) of cultural heritage in a genAI and post-genAI world.
Interspecific Hardy Geranium Progenies: Morphological Characterization and Genetic Evaluation
Authors: Akbarzadeh Mehrdad , Van Laere Katrijn , De Keyser Ellen , Van Huylenbroeck Johan , Werbrouck Stefaan P. O. , Dhooghe Emmy
Published: July 2024

Hardy geranium is a popular ornamental plant with a high market demand. As a result, there is a strong need for continuous innovation to improve its ornamental qualities. Interspecific hybridization is a widely used technique for introducing desirable traits and creating new cultivars with added value. To explore the possibilities of creating novelty within the Geranium genus, we conducted 2438 interspecific crosses over three flowering seasons, resulting in the successful harvest of 445 seeds and the final production of 82 seedlings. Using embryo rescue increased the germination rate of a seedling from 0.17% to 1.01%. To validate the paternal genetic contribution in the new seedlings, we used amplified fragment length polymorphism (AFLP) to assess the proportion of uniquely inherited paternal markers in all seedlings. AFLP analysis confirmed that 54 of the 82 seedlings were indeed true hybrids (65.8% hybridization success rate). A morphological evaluation of the flowers and leaves, including flower diameter (mm), style length (mm), number of flowers, flowering period (weeks), and color of both flowers and leaves, provided further confirmation of the F1 hybrid status of the seedlings. The results of our interspecific breeding demonstrated the efficiency of interspecific hybridization in hardy geraniums and its potential to create distinctive and novel cultivars for the ornamental market.
Agricultural Drought Model Based on Machine Learning Cubist Algorithm and Its Evaluation
Authors: Sha Sha , Wang Lijuan , Hu Die , Ren Yulong , Wang Xiaoping , Zhang Liang
Published: July 2024

Soil moisture is the most direct evaluation index for agricultural drought. It is not only directly affected by meteorological conditions such as precipitation and temperature but is also indirectly influenced by environmental factors such as climate zone, surface vegetation type, soil type, elevation, and irrigation conditions. These influencing factors have a complex, nonlinear relationship with soil moisture. It is difficult to accurately describe this non-linear relationship using a single indicator constructed from meteorological data, remote sensing data, and other data. It is also difficult to fully consider environmental factors using a single drought index on a large scale. Machine learning (ML) models provide new technology for nonlinear problems such as soil moisture retrieval. Based on the multi-source drought indexes calculated by meteorological, remote sensing, and land surface model data, and environmental factors, and using the Cubist algorithm based on a classification decision tree (CART), a comprehensive agricultural drought monitoring model at 10 cm, 20 cm, and 50 cm depth in Gansu Province is established. The influence of environmental factors and meteorological factors on the accuracy of the comprehensive model is discussed, and the accuracy of the comprehensive model is evaluated. The results show that the comprehensive model has a significant improvement in accuracy compared to the single variable model, which is a decrease of about 26% and 28% in RMSE and MAPE, respectively, compared to the best MCI model. Environmental factors such as season, DEM, and climate zone, especially the DEM, play a crucial role in improving the accuracy of the integrated model. These three environmental factors can comprehensively reduce the average RMSE of the comprehensive model by about 25%. Compared to environmental factors, meteorological factors have a slightly weaker effect on improving the accuracy of comprehensive models, which is a decrease of about 6.5% in RMSE. The fitting accuracy of the comprehensive model in humid and semi-humid areas, as well as semi-arid and semi-humid areas, is significantly higher than that in arid and semi-arid areas. These research results have important guiding significance for improving the accuracy of agricultural drought monitoring in Gansu Province.
The Role of Delay Time in the Preliminary Assessment of the Seismic Resilience (SR) of a Bridge: A Case Study
Authors: Baciocchi Federico , Forcellini Davide
Published: July 2024

The seismic resilience of bridges has become an important concept in civil engineering since these systems need to remain operative during and after earthquakes. In this regard, the definition of recovery needs to consider the delay time (named as the time between an event and the beginning of the recovery process). The original concept of seismic resilience has been expanded herein in order to account for the delay time of bridge configurations. Its role in the quantification of seismic resilience has been investigated by performing a case study of a Californian highway bridge subjected to an ensemble of 100 input motions. The results demonstrate that the delay time may significantly reduce the seismic resilience of bridges.
Characterisation of Tenebrio molitor Reared on Substrates Supplemented with Chestnut Shell
Authors: Ferri Irene , Dell’Anno Matteo , Spano Mattia , Canala Benedetta , Petrali Beatrice , Dametti Matilda , Magnaghi Stefano , Rossi Luciana
Published: July 2024

Tenebrio molitor larvae represent a sustainable protein source for food and feed. The aim of this study was to evaluate the supplementation of chestnut shell, a by-product of the agro-industrial chain, in growth substrates for T. molitor larvae rearing. Seven-week-old larvae were reared on three different growth substrates: the control group (CTRL) was fed wheat bran, treatment group one was fed wheat bran supplemented with 12.5% w/w chestnut shell (TRT1), and treatment group two was fed wheat bran supplemented with 25% w/w chestnut shell (TRT2). Larval weight, substrate consumption, and mortality were recorded weekly. After 14 days, insect meals were produced for bromatological and colorimetric analysis, and bacterial inhibition activity assay using a microdilution method. The amino acid profile of insects was determined using quantitative nuclear magnetic resonance spectroscopy. Our results showed a lower feed conversion ratio and higher larval survival rate % in TRT2 compared to CTRL (p < 0.05). Proteins and lipids of TRT2 were higher than other groups (p < 0.05). Important differences were observed in the amino acid profile of TRT1 and TRT2 compared to CTRL (p < 0.05). TRT1 and TRT2 showed higher E. coli inhibitory activity than CTRL (p < 0.05). In conclusion, chestnut shell supplementation improved the survival and functional characteristics of larvae and likely impacted the insects’ metabolism.
Pharmacomechanical Thrombectomy and Catheter-Directed Thrombolysis, with or without Iliac Vein Stenting, in the Treatment of Acute Iliofemoral Deep Vein Thrombosis
Authors: Ozcinar Evren , Dikmen Nur , Kayan Ahmet , Kandemir Melisa , Saricaoglu Mehmet Cahit
Published: July 2024

Background: This study aims to evaluate and compare the outcomes and clinical efficacy of pharmacomechanical thrombectomy (PMCT) plus catheter-directed thrombolysis (CDT) and PMCT combined with CDT and venous stenting in managing acute iliofemoral deep vein thrombosis (DVT), while also assessing the long-term safety and efficacy of these interventions. Methods: A retrospective case–control study spanning 3 years involved 112 patients presenting with acute symptomatic iliofemoral deep vein thrombosis (DVT), each with a symptom duration of less than 14 days. Patients were consecutively categorized into two groups based on individual clinical indications: PMCT + CDT vs. PMCT + CDT + venous stent. Statistical analyses were conducted to compare clinical features and outcomes between the two groups. Additionally, patients were followed up for 24 months post-treatment, during which quality of life (QoL) and severity of post-thrombotic syndrome (PTS) were analyzed. Results: In this retrospective study, we analyzed a total of 112 consecutive patients, with 63 patients undergoing PMCT + CDT and 49 patients undergoing PMCT + CDT + venous stent. Between the two groups, regarding primary outcomes at 6 months, there was no difference in the observed cumulative patency rates, standing at 82.5% for PMCT + CDT and 81.6% for PMCT + CDT + stent. Survival analyses for primary, primary-assisted, and secondary patency yielded comparable results for PMCT + CDT, with p-values of 0.74, 0.58, and 0.72, respectively. The two-year patency rate was high in both groups (85.7% for PMCT + CDT vs. 83.7% for PMCT + CDT + stent). Additionally, during the follow-up period, there were no statistically significant differences observed in the incidence of PTS or the average Villalta score between the two groups. At 24 months post-intervention, the incidence of post-thrombotic syndrome (PTS) was 11.1% in the PMCT + CDT group and 22% in the PMCT + CDT + stent group (p = 0.381). Both treatment arms of the study groups experienced bleeding complications during the thrombolysis therapy; in the PMCT + CDT group, there were three cases of gastrointestinal bleeding, compared to two cases in the PMCT + CDT + stent group (p = 0.900). Additionally, there was one intracranial hemorrhage in the PMCT + CDT group and two in the PMCT + CDT + stent group. Conclusions: Pharmacomechanical thrombectomy (PMCT) combined with catheter-directed thrombolysis (CDT) therapy has shown significant efficacy in alleviating leg symptoms and reducing the occurrence of post-thrombotic syndrome (PTS), including the incidence of moderate-to-severe PTS. On the other hand, the utilization of PMCT + CDT + stent therapy, tailored to individual patients’ clinical and venous conditions, may enhance long-term venous patency and lead to superior outcomes, including improved quality of life parameters.
Improvement of Cardiac Function and Subcellular Defects Due to Chronic Diabetes upon Treatment with Sarpogrelate
Authors: Tappia Paramjit S. , Elimban Vijayan , Shah Anureet K. , Goyal Ramesh K. , Dhalla Naranjan S.
Published: July 2024

In order to investigate the subcellular mechanisms underlying the beneficial effects of sarpogrelate—a 5-HT2A receptor antagonist—on diabetic cardiomyopathy, diabetes was induced in rats by injecting streptozotocin (65 mg/kg). Diabetic animals were treated with or without sarpogrelate (5 mg/kg daily) for 6 weeks; diabetic animals were also treated with insulin (10 units/kg daily) for comparison. Elevated plasma levels of glucose and lipids, depressed insulin levels, hemodynamic alterations and cardiac dysfunction in diabetic animals were partially or fully attenuated by sarpogrelate or insulin treatment. Diabetes-induced changes in myocardial high-energy phosphate stores, as well as depressed mitochondrial oxidative phosphorylation and Ca2+-uptake activities, were significantly prevented by these treatments. Reductions in sarcolemma Na+-K+ ATPase, Na+-Ca2+ exchange, Ca2+-channel density and Ca2+-uptake activities were also attenuated by treatments with sarpogrelate and insulin. In addition, decreases in diabetes-induced sarcoplasmic reticulum Ca2+-uptake, Ca2+-release and Ca2+-stimulated ATPase activities, myofibrillar Mg2+-ATPase and Ca2+-stimulated ATPase activities, and myosin Mg2+-ATPase and Ca2+-ATPase activities were fully or partially prevented by sarpogrelate and insulin treatments. Marked alterations in different biomarkers of oxidative stress, such as malondialdehyde, superoxide dismutase and glutathione peroxidase, in diabetic hearts were also attenuated by treating the animals with sarpogrelate or insulin. These observations suggest that therapy with sarpogrelate, like that with insulin, may improve cardiac function by preventing subcellular and metabolic defects as a consequence of a reduction in oxidative stress.
Understanding Internalized Stigma’s Role in Sex-Specific Suicidal Ideation among Individuals with Bipolar Disorder
Authors: D’Angelo Martina , Steardo Luca
Published: July 2024

Background: The experience of stigma can exert a profound impact on the mental health and well-being of individuals with bipolar disorder (BD). Our study explores which factors of internalized stigma are associated with suicidal ideation and how they differ between the two sexes in a clinical sample of BD patients. Methods: The study follows a cross-sectional study design, employing the Clinical Global Impression for Bipolar Patients (CGI-BP) to evaluate the overall severity of illness and the alteration in patients affected by bipolar disorder, the Internalized Stigma of Mental Illness (ISMI) assessing self-stigma among individuals experiencing mental disorders, and the Columbia Suicide Severity Rating Scale (C-SSRS) identifying and assessing individuals vulnerable to suicide. Descriptive analyses, analysis of variance (ANOVA), and logistic regression analysis were conducted, and 344 BD subjects were recruited. Results: Our ANOVA results revealed a significant association between sex and suicide across ISMI sub-items (p = 0.000). Logistic regression analysis comprised three phases: Discrimination was consistently significant across all phases (p < 0.001), while Alienation and Stereotype emerged as additional predictors of suicide in later phases of the analysis (p < 0.001). Conclusions: Our study contributes to the growing body of literature on internalized stigma, sex, and suicidality among individuals with bipolar disorder. Early intervention programs and prevention strategies are needed.
Nonlinear Soil–Pile–Structure Interaction Behaviour of Marine Jetty Structures
Authors: Koronides Marios , Michailides Constantine , Onoufriou Toula
Published: July 2024

Nonlinear soil–pile–structure interaction (SPSI) phenomena are known to play a vital role in the response of bottom-fixed marine structures. For such structures, these phenomena are commonly considered by the imposition of p-y, τ-z, and q-z springs, representing the lateral and axial shaft and axial base soil resistances, respectively. The importance of each resistance mechanism depends on the type of foundation system, with only very limited studies investigating their roles in the response of piled marine structures, such as jetties. Within this context, this study presents numerical three-dimensional pushover analysis results for two marine jetties, a smaller model with four piles and a larger model supported by twenty-four piles. SPSI effects are considered through p-y, τ-z, and q-z springs, the behaviours of which are determined by following commonly employed procedures. The structures’ responses are investigated under the influence of various assumptions regarding the behaviours of springs, as well as steel plasticity. The current investigation underscores the substantial influence of the axial soil–pile interaction on the response of the jetty, particularly in terms of its failure mode. Moreover, it demonstrates the importance of incorporating p-y springs, even though the choice between their linear or nonlinear constitutive behaviour is found to be less critical. Finally, the study concludes that the behaviours of the springs significantly affect the system’s ductility and the degree of steel yielding in the piles, while also highlighting the unconservative influence of neglecting SPSI phenomena.
Paradoxical Roles of Carbon Nanotubes in Cancer Therapy and Carcinogenesis
Authors: Xu Bohan , Wu Shunjie , Wang Yiyang , Ji Yuhe , Liang Shufeng , Wang Chunyan , Tian Xin
Published: July 2024

Carbon nanotubes (CNTs), members of the nanomaterial family, are increasingly being used in consumer products and extensively studied for various biomedical applications. Due to their benign elemental composition, large surface area, and chemical and biological activities, CNTs demonstrate great potential in cancer therapy, including drug delivery, imaging analysis, photothermal therapy, photodynamic therapy, and radiotherapy. However, there is still a major knowledge gap when it comes to transitioning from research to clinical applications. One of the important issues is that the biological toxicity of CNTs, especially in terms of carcinogenesis, and the underlying mechanisms are not fully understood. Therefore, a thorough evaluation of toxicity and the underlying mechanisms of carcinogenesis is essential to enable the wide application of CNTs. In this review, we summarize the recent progress of CNTs as multifunctional therapeutics in cancer therapy. Furthermore, a detailed discussion is provided on the carcinogenesis and potential mechanisms of CNTs. Finally, the review ends with further challenges and prospects for CNTs with the expectation of facilitating their broader utilization.