bluuebunny/crossref_metadata_2025 huggingface dataset:
Retrofit pada Bangunan Komersial: Tinjauan Masalah dan Metode
Authors: Tasya Annisa Fikriyah , Setijanti Purwanita , Dinapradipta Asri
Published: November 2020

At present energy efficiency is the main target to reduce building operating costs and achieve sustainability. The use of energy in buildings can be done through retrofitting. In addition, retrofitting has the potential to reduce carbon emissions, but there are also those who have to release some building features if necessary, energy features that are applied to existing buildings that have been issued to carry out renovations. Building reinforcement is a complex act, with various criteria that must be met with each other to achieve sustainable use of buildings. This article discusses the benefits, criteria, analytic methods, and decision making processes used to improve commercial buildings. The main criteria for increased energy consumption. Some other criteria are building materials, economy and occupants' needs. The analytical method for estimating or measuring the increase in retrofit that will be discussed in this article is a simulation of building energy. This method is widely used because it can predict the condition of buildings in the future. Each retrofit step is chosen and approved by the several factors; regulations, risks, business sustainability, knowledge, awareness and occupant demand. The retrofit valuation process is based on the value at which financial performance is taken into account. Retrofitting carried out on commercial buildings, applied with care, not only provides opportunities to reduce energy consumption and carbon emissions, but can also increase the value of these properties.
Effect of 24/7 attending coverage in the Neonatal Intensive Care Unit on fellow education.
Authors: Sahni Mitali , Mowes Anja
Published: November 2020

BackgroundThere is a current change in type of attending coverage in the Neonatal Intensive Care Unit (NICU) from home calls to 24/7 in House. Effects of this increased attending physician presence on education of NICU fellows has not been studied. The objective of this study is to evaluate the fellows’ perception of in house attending coverage on their education and evaluate its effect on their perceived autonomy.MethodsA secure, anonymous, web-based survey was designed using RedCap. The web-based survey was sent via the section of Neonatal Perinatal Medicine of the American Academy of Pediatrics, to all members of Training & Early Career Neonatologists. Questions were focused on perception of IH attending coverage on fellows’ educational experience including the respondent’s perceived ability to make independent decisions (autonomy). Chi-square tests were used to compare responses between groups, with Fisher Exact tests used when the expected cell frequencies were small.Results One hundred and twenty-three surveys were analyzed, that included responses from 82 fellows & 41 early career neonatologists. 52% reported having 24/7 attending in-house (IH) coverage. 30 of the 123 respondents experienced a change in model of attending coverage during their training. Among these 30, only 26.6% preferred the model of attending IH coverage. The respondents currently working in IH models, when compared to those in non-IH coverage models felt IH attending coverage was beneficial for fellow education (p <0.05) but was less likely to give fellows autonomy for decision making (p=0.02).ConclusionIn our survey respondents with in house attending, had a more favorable view of its benefit on fellow education. Institutions practicing or considering IH attending coverage should consider use of adequate measures to balance fellow supervision and education.
Neuromedin B Promotes Chondrocyte Differentiation of Mesenchymal Stromal Cells Via Calcineurin and Calcium Signaling
Authors: Maumus Marie , Fonteneau Guillaume , Ruiz Maxime , Assou Said , Boukhaddaoui Hassan , Pastoureau Philippe , De Ceuninck Frédéric , Jorgensen Christian , Noël Danièle
Published: November 2020

Background: Articular cartilage is a complex tissue with poor healing capacities. Current approaches for cartilage repair based on mesenchymal stromal cells (MSCs) are often disappointing because of the lack of relevant differentiation factors that could drive MSC differentiation towards a stable mature chondrocyte phenotype. Methods: We used a large-scale transcriptomic approach to identify genes that are modulated at early stages of chondrogenic differentiation using the reference cartilage micropellet model. Results: We identified several modulated genes and selected neuromedin B (NMB) as one of the early and transiently modulated genes. We found that the timely regulated increase of NMB was specific for chondrogenesis and not observed during osteogenesis or adipogenesis. Furthermore, NMB expression levels correlated with the differentiation capacity of MSCs and its inhibition resulted in impaired chondrogenic differentiation indicating that NMB is required for chondrogenesis. We further showed that NMB activated the calcineurin activity through a Ca++-dependent signaling pathway. Conclusion: NMB is a newly described chondroinductive bioactive factor that upregulates the key chondrogenic transcription factor Sox9 through the modulation of Ca2+ signaling pathway and calcineurin activity.
Knowledge, Attitude and Practices on Cervical Cancer Screening, Prevention, and Control among Undergraduate Female Students in Northwest, Ethiopia: A Descriptive Cross Sectional Study
Authors: Getaneh Alem , Tegegne Birhanemesikel , Belachew Teshome
Published: November 2020

Background

In the world, cervical cancer is an easily preventable disease and it is one of the leading causes of cancer mortality in females. It is the second most common women cancer in Ethiopia. The aim of the present study was to assess the KAP of undergraduate female students towards cervical cancer screening, prevention, and control.
Methods

A cross-sectional study was conducted in April 2018 at the University of Gondar, College of Medicine and Health Sciences undergraduate female students. Pretested, self-administered questionnaire was used for data collection. Four hundred and three female students were recruited by a stratified random sampling method and the data were entered and analyzed using SPSS version 20 statistical packages. Descriptive data analysis was used to report the results.
Results

Most of the respondents (59.3.3%) had good knowledge, whereas nearly 67.7% of the respondents had a positive attitude towards cervical cancer. However, less than 1% of the respondents had been screened for cervical cancer.
Conclusion

Although female students had a high proportion of good knowledge and a positive attitude, their practices on cervical cancer were quite low. Therefore the university should create awareness on cervical cancer screening, prevention, and control by incorporating in the curriculum.
Does the Medical Insurance System Play a Real Role in Reducing Catastrophic Economic Burden in Elderly Patients With Cardiovascular Disease in China? Implication for Accurately Targeting Vulnerable Characteristics.
Authors: Ma Meiyan , Ye Li , Li Yuze , Wang Nianshi , Wu Qunhong , Shan Linghan , Xia Qi , Zhang Xiyu , Miao Wenqing , Tian Wanxin , You Dingyun , Shi Baoguo , Li Heng , Sun Tao , Fu Xuelian , Hao Yanhua , Gao Han
Published: November 2020

BackgroundThe vulnerability of cardiovascular disease (CVD) patients’ health abilities, combined with the severity of the disease and the overlapping risk factors, can cause such people to bear the economic burden of the disease due to the medical services.We estimated the economic burden of CVD，and identified the weak link in the design of the medical insurance.MethodsData from 5,610 middle-aged and elderly with CVD were drawn from the 2015 wave of China Health and Retirement Longitudinal Study (CHARLS). The recommended method of the World Health Organization (WHO) was adopted to calculate catastrophic health expenditure (CHE), impoverishment by medical expenses (IME), and applied the treatment-effect model to analyze the determinants of CHE.ResultsThe incidence of CHE was 19.9% of the CVD, compared to 7.6% of the sample households trapped in IME. The incidence of CHE in CVD participating in medical insurance was 2.6% higher than for uninsured families (16.3%).Family size, health satisfaction,combine with other chronic diseases, having hospitalization and disabled members, and participating in insurance were found to be significantly associated with the CHE.Conclusions﻿Elderly with physical vulnerabilities were more prone to CHE. The medical insurance only reduced barriers to accessing health resources for elderly with CVD, but lacked policy inclination for high-utilization populations,and had poorly accurate identification of vulnerable characteristics of CVD,which in turn affects the economic protection ability of the medical insurance. The dispersion between the multiple medical security systems leads to the existence of blind spots in the economic risk protection of individuals and families.
Combination of CT Imaging-based Radiomics and Clinicopathological Characteristics for Predicting the Clinical Benefit of Immune Checkpoint Inhibitors in Lung Cancer
Authors: Yang Bin , Zhou Li , Zhong Jing , Lv Tangfeng , Li Ang , Ma Lu , Zhong Jian , Yin Saisai , Huang Litang , Zhou Changsheng , Li Xinyu , Ge YingQian , Tao Xinwei , Zhang Longjiang , Song Yong , Lu Guangming
Published: November 2020

PurposeIn this study, we tested whether a combination of radiomic features extracted from baseline pre-immunotherapy computed tomography (CT) images and clinicopathological characteristics could be used as novel noninvasive biomarkers for predicting the clinical benefits of non-small cell lung cancer (NSCLC) patients treated with immune checkpoint inhibitors (ICIs).MethodsData on 92 consecutive patients with lung cancer who had been treated with ICIs were retrospectively analyzed. In total, 88 radiomic features were selected from the pretreatment CT images for the construction of a random forest model. Radiomics model 1 was constructed based on the rad-score.Through multivariate logistic regression analysis, the rad-score and significant predictors were integrated into a single predictive model (radiomics nomogram model 1) to predict the durable clinical benefit from ICIs. Radiomics model 2 was developed based on the same rad-score as radiomics model 1. Through multivariate Cox proportional hazards regression analysis using the rad-score and independent risk factors, radiomics nomogram model 2 was constructed to predict the progression-free survival (PFS).ResultsThe models successfully predicted the patients who would benefit from ICIs. With radiomics model 1, the area under the receiver operating characteristic curve values for the training and validation cohorts were 0.848 and 0.795, respectively, whereas with radiomics nomogram model 1, the values were 0.902 and 0.877, respectively. For the PFS prediction, the Harrell’s concordance indexes for the training and validation cohorts were 0.717 and 0.760, respectively, with radiomics model 2, whereas they were 0.749 and 0.791, respectively, with radiomics nomogram model 2.ConclusionCT-based radiomic features and clinicopathological factors can be used prior to the initiation of immunotherapy for identifying NSCLC patients who are the most likely to benefit from the therapy. This could be a step forward toward the realization of precision medicine and individualized decision support for patients with advanced NSCLC.
Primary Renal Pelvis Squamous Cell Carcinoma: A Case Report
Authors: Xiao Wei , Cai Hongjia , Wang Xiaomin , Zhang Neng
Published: November 2020

Background: Primary renal pelvic squamous cell carcinoma (SCC) is exceedingly rare neoplasm and poor prognosis. We reported a patient who underwent surgery for radical nephrectomy.Methods and results: The patient was a 72-year old man, who visited doctors with complaints of dull aching in right flank region and occasional gross hematuria. Abdominal contrast-enhanced magnetic resonance imaging (MRI) revealed a neoplasm and hydronephrosis in the right kidney. The preoperative diagnosis of malignant tumor in right kidney was made by urologist, and open radical nephrostomy was performed. The resected tumor was shown histologically to be squamous cell carcinoma of right renal pelvis.Conclusions: Renal SCC is a rare tumor usually presented in advanced stage with poor prognosis. Early diagnosis and surgical treatment are beneficial for patients’ survival. Most patients are associated with risk factors of Renal SCC such as renal calculi and infection, but patient with no risk factors shouldn’t be ignored. We encountered a rare case with no risk factors.
High Level Plasmid-Mediated Quinolone Resistance in Clinical Infections at a Tertiary Healthcare Institution in South-West Nigeria
Authors: Ojewuyi Abiodun Ronke , Odetoyin Babatunde , Aboderin Aaron Oladipo
Published: November 2020

Background Plasmid-mediated quinolone resistance (PMQR) has become a growing clinical concern worldwide. Recent reports from Nigeria revealed that qunolone resistant clinical isolates have become commomplace. However, few reports regarding the prevalence of PMQR are available. Hence, this study aimed to determine the prevalence of PMQR genes in qunolone resistant clinical isolates from a tertiary care hospital in Nigeria. Methods This was a cross-sectional hospital based study involving 390 non-repetitive Gram negative bacilli from diverse clinical infections. The isolates were characterized by the MicrobactTM identification kit and their susceptibility patterns determined by the Kirby-Bauer disc diffusion technique. All quinolone resistant isolates were investigated for the carriage of PMQR genes by multiplex polymerase chain reaction (PCR). Data analysis was with appropriate descriptive and inferential statistics.Results The isolates were distributed as Escherichia coli (n=121; 31.0%), Klebsiella species (n= 112;28.7%), Pseudomonas aeruginosa (n=59;15.1%), Proteus species (n=43;11.0%), Salmonella species (n=6;1.3%) and others. They were commonly resistant to nalidixic (62.6%), co-amoxiclav (57.7%); norfloxacin (52.3%), ofloxacin(52.1%) and ciprofloxacin(51.0%), but were least resistant to imipenem; (n=36; 9.2%). Out of 244 isolates that were resistant to at least one quinolone, 180 (73.8%) harboured one or more PMQR gene with a high prevalence of efflux-mediating determinants (qepA, 22.5%; oqxAB, 21.1%), and the aminoglycoside acetyltransferase (aac(6’)-Ib-cr, 19.7%). Proportionately low level of target-protecting determinants; qnrB, 13.2%; qnrS, 8.7%; qnrA, 5.9%; qnrD, 4.5% and qnrC, 4.2% were found in these isolates.Conclusion There is high level quinolone resistance and wide distribution of PMQR genes in clinical isolates in Nigeria with a preponderance of Efflux-mediating determinants and the aminoglycoside acetyltransferase. This emphasizes the need for regular resistance surveillance and antimicrobial stewardship to guide the appropriate and judicious use of antibiotics.
Compliance of daily iron supplementation during pregnancy affecting the hemoglobin level in second trimester and at term
Authors: S Romthira - , Thinkhamrop Jadsada , Chaiyarach Sukanya - , Kreetiyutanont Sukanya -
Published: November 2020

Objectives: To determine the compliance rate of iron supplementation during pregnancy and the hemoglobin concentration in second trimester and at term.Methods: The study conducted among term pregnant women admission to the hospital for delivery who had non-anemic status at the initial visit for antenatal care, received daily iron supplementation before 20 weeks of gestation. They were interviewed to obtain the personal data, daily taking the supplemented tablet and side-effects. The compliance rate categorized as >80%, >50-80%, 25-50%, and < 25% according to the women’s response that they took daily tablet of 6-7, 3-5, 2, and 0-1 days/week, respectively. The type of supplementation and laboratory results of hemoglobin level were retrieved from their medical records.Results: Almost 90% of 350 participants had the compliance rate of >80%. The common side-effects were nausea and constipation. The side-effect rates were 10.5%, 12.1%, 66.7% in >80%, >50-80%, <25% compliance groups, respectively. In second trimester and term pregnancy revealed some anemic women. While hemoglobin concentrations above 13 gm/dl, which defined as high concentrated hemoglobin, revealed 12% during second trimester, and up to 30% at term in high compliance group.Conclusions: There was high compliance rate of iron supplementation with the high hemoglobin level markedly found in high compliance group.
Urinary microRNA Biomarkers for Detecting the Presence of Esophageal Cancer
Authors: Okuda Yusuke , Shimura Takaya , Iwasaki Hiroyasu , Fukusada Shigeki , Nishigaki Ruriko , Kitagawa Mika , Katano Takahito , Okamoto Yasuyuki , Yamada Tamaki , Horike Shin-ichi , Kataoka Hiromi
Published: November 2020

Background: Esophageal cancer (EC) including esophageal squamous cell carcinoma (ESCC) and adenocarcinoma (EAC) generally exhibits poor prognosis; hence, a noninvasive biomarker enabling early detection is necessary. Thus, this study aimed to establish novel urinary miRNA biomarkers for diagnosing EC.Methods: Out of 343 patients (299 healthy controls [HCs] and 44 ESCCs), 150 HCs and 43 patients with ESCC, which were both age- and sex-matched, were analyzed and randomly divided into two groups: 9 patients (6 HCs and 3 ESCCs) in the discovery cohort for microarray analysis and 184 patients (144 HCs and 40 ESCCs) in the training/test cohort with cross-validation for qRT-PCR analysis. Using 152 urine samples (144 HCs and 8 EACs), we validated the urinary miRNA biomarkers for EAC diagnosis.Results: Eight miRNAs were selected as biomarker candidates in the discovery cohort. In the training/test cohort, five of the eight miRNAs (miR-1273f, miR-619-5p, miR-150-3p, miR-4327, and miR-3135b) in the ESCC group had significantly higher urinary levels than those in the HC group. Consistently, these five urinary miRNAs were significantly different between HC and ESCC in both training and test sets. Especially, urinary miR-1273f and miR-619-5p showed excellent values of area under the curve (AUC) ≥ 0.80 for diagnosing stage I ESCC. Consistent with the ESCC group, the EAC group had significantly higher urinary levels of these five miRNAs than the HC group, and it also exhibited AUC values of approximately 0.80.Conclusion: The present study established novel urinary miRNA biomarkers that can early detect ESCC and EAC.
Human Cost of Tyranny in Kurdistan Region of Iraq
Authors: Ameen Jamal
Published: November 2020

Background The 2003 liberation/invasion of Iraq and the resulting casualties from civilians and armed forces attracted researchers publishing in high prestigious journals but little mentioned about the events that led to the armed intervention. This paper is assessing the human cost of successive Iraqi governments tyrannical rule in Kurdistan Region of Iraq over three decades.Method The two most recent and reliable census datasets of 1947 and 1957 were used to estimate fertility and survival rates by age group under normal circumstances. These were used in the classical Leslie Matrix to predict 2007 Kurdistan Region of Iraq population. Results were contrasted with estimates for the same year that were obtained by the World Food Programme as part of their Food Security Analysis for Iraq to arrive at estimates that would indicate the scale of the loss in human capital from Saddam’s tyranny that was imposed on the region. Findings Kurdistan Region has lost around 1,911,479 of which 1,043,549 were male and 867,930 female of different age groups. These include direct victims of the past genocide actions of successive Iraqi governments as well as those who thought refuge beyond the boundaries of Kurdistan Region during the past decades. Interpretation Saddam’s actions were directed to all indigenous inhabitants irrespective of gender and age. As such, any possible offspring, had life continued as normal, is counted as human loss. Impacts of changes in demography, socio-political and the environment of Saddam’s tyrannical rule are worth further investigation.Funding None
Integrative transcriptomic, proteomic, and machine learning approach to identifying feature genes of atrial fibrillation
Authors: Liu Yaozhong , Bai Fan , Tang Zhenwei , Liu Na , Liu Qiming
Published: November 2020

Background: Atrial fibrillation (AF) is the most common arrhythmia with poorly understood mechanisms. We aimed to investigate the biological mechanism of AF and to discover feature genes by analyzing multi-omics data and by applying a machine learning approach. Methods: At the transcriptomic level, four microarray datasets (GSE41177, GSE79768, GSE115574, GSE14975) were downloaded from the Gene Expression Omnibus database, which included 130 available atrial samples from AF and sinus rhythm (SR) group. Microarray meta-analysis was adopted to identified differentially expressed genes (DEGs). At the proteomic level, a qualitative and quantitative analysis of proteomics in the left atrial appendage of 18 patients (9 with AF and 9 with SR) was conducted. The machine learning correlation-based feature selection (CSF) method was introduced to selected feature genes of AF using the training set of 130 samples involved in the microarray meta-analysis. The Naive Bayes (NB) based classifier constructed using training set was evaluated on an independent validation test set GSE2240. Results: 863 DEGs with a FDR<0.05 and 482 differentially expressed proteins (DEPs) with a FDR<0.1 and fold change >1.2 were obtained from the transcriptomic and proteomic study, respectively. The DEGs and DEPs were then analyzed together which identified 30 biomarkers with consistent trends. Further, 10 feature, including 8 upregulated genes (CD44, CHGB, FHL2, GGT5, IGFBP2, NRAP, SEPTIN6, YWHAQ) and 2 downregulated genes (TNNT1, TRDN) were selected from the 30 biomarkers through machine learning CFS method using training set. The NB based classifier constructed using the training set accurately and reliably classify AF from SR samples in the validation test set with a precision of 87.5% and AUC of 0.995.Conclusion: Taken together, our present work might provide novel insights into the molecular mechanism and provide some promising diagnostic and therapeutic targets of AF.
Generation of restriction endonucleases barcode map to trace SARS-CoV-2 origin and evolution.
Authors: Colombo Federico , Corsiero Elisa , Lewis Myles J. , Pitzalis Costantino
Published: November 2020

Since the first report of SARS-CoV-2 in China in 2019, there has been a huge debate about the origin. In this work, using a different method we aimed to strengthen the observation that no evidence of genetic manipulation has been found by i) detecting classical restriction site (RS) sequence in human SARS-CoV-2 genomes and ii) comparing them with other recombinant SARS-CoV-like virus created for experimental purposes. Finally, we propose a novel approach consisting in the generation of a restriction endonucleases site map of SARS-CoV-2 and other related coronavirus genomes to be used as a fingerprint to trace the virus evolution.