bluuebunny/crossref_metadata_2025 huggingface dataset:
A novel retroviral vector system to analyze expression from mRNA with retained introns using fluorescent proteins and flow cytometry
Authors: Jackson Patrick E. H. , Huang Jing , Sharma Monika , Rasmussen Sara K. , Hammarskjold Marie-Louise , Rekosh David
Published: April 2019

The ability to overcome cellular restrictions that exist for the export and translation of mRNAs with retained introns is a requirement for the replication of retroviruses and also for the expression of many mRNA isoforms transcribed from cellular genes. In some cases, RNA structures have been identified in the mRNA that directly interact with cellular factors to promote the export and expression of isoforms with retained introns. In other cases, a viral protein is also required to act as an adapter. In this report we describe a novel vector system that allows measurement of the ability of cis- and trans-acting factors to promote the export and translation of mRNAs with retained introns. One reporter vector used in this system is derived from an HIV proviral clone engineered to express two different fluorescent proteins from spliced and unspliced transcripts. The ratio of fluorescent signals is a measurement of the efficiency of export and translation. A second vector utilizes a third fluorescent protein to measure the expression of viral export proteins that interact with some of the export elements. Both vectors can be packaged into viral particles and be used to transduce cells, allowing expression at physiological levels from the integrated vector.
Semisynthetic aurones inhibit tubulin polymerization at the colchicine-binding site and repress PC-3 tumor xenografts in nude mice and myc-induced T-ALL in zebrafish
Authors: Xie Yanqi , Kril Liliia M. , Yu Tianxin , Zhang Wen , Frasinyuk Mykhaylo S. , Bondarenko Svitlana P. , Kondratyuk Kostyantyn M. , Hausman Elizabeth , Martin Zachary M. , Wyrebek Przemyslaw P. , Liu Xifu , Deaciuc Agripina , Dwoskin Linda P. , Chen Jing , Zhu Haining , Zhan Chang-Guo , Sviripa Vitaliy M. , Blackburn Jessica , Watt David S. , Liu Chunming
Published: April 2019

Structure-activity relationships (SAR) in the aurone pharmacophore identified heterocyclic variants of the (Z)-2-benzylidene-6-hydroxybenzofuran-3(2H)-one scaffold that possessed low nanomolar in vitro potency in cell proliferation assays using various cancer cell lines, in vivo potency in prostate cancer PC-3 xenograft and zebrafish models, selectivity for the colchicine-binding site on tubulin, and absence of appreciable toxicity. Among the leading, biologically active analogs were (Z)-2-((2-((1-ethyl-5-methoxy-1H-indol-3-yl)methylene)-3-oxo-2,3-dihydrobenzofuran-6-yl)oxy)acetonitrile (5a) and (Z)-6-((2,6-dichlorobenzyl)oxy)-2-(pyridin-4-ylmethylene)benzofuran-3(2H)-one (5b) that inhibited in vitro PC-3 prostate cancer cell proliferation with IC50 values below 100 nM. A xenograft study in nude mice using 10 mg/kg of 5a had no effect on mice weight, and aurone 5a did not inhibit, as desired, the human ether-à-go-go-related (hERG) potassium channel. Cell cycle arrest data, comparisons of the inhibition of cancer cell proliferation by aurones and known antineoplastic agents, and in vitro inhibition of tubulin polymerization indicated that aurone 5a disrupted tubulin dynamics. Based on molecular docking and confirmed by liquid chromatography-electrospray ionization-tandem mass spectrometry studies, aurone 5a targets the colchicine-binding site on tubulin. In addition to solid tumors, aurones 5a and 5b strongly inhibited in vitro a panel of human leukemia cancer cell lines and the in vivo myc-induced T cell acute lymphoblastic leukemia (T-ALL) in a zebrafish model.
Optical intrinsic signal imaging with optogenetics reveals functional cortico-cortical connectivity at the columnar level in living macaques
Authors: Nakamichi Yu , Okubo Kai , Sato Takayuki , Hashimoto Mitsuhiro , Tanifuji Manabu
Published: April 2019

Despite extensive research on primate cognitive function, understanding how anatomical connectivity at a neural circuit level relates to information transformation across different cortical areas remains primitive. New technology is needed to visualize inter-areal anatomical connectivity in living monkeys and to tie this directly to neurophysiological function. Here, we developed a novel method to investigate this structure-function relationship, by combining optical intrinsic signal imaging (OISI) with optogenetic stimulation in living monkeys (opto-OISI). The method involves expressing channelrhodophsin-2 in one area (source) followed by optical imaging of optogenetic activations in the other area (target). We successfully demonstrated the potential of the method with interhemispheric columnar projection patterns between V1/V2 border regions. Unlike the combination of optogenetics and functional magnetic resonance imaging (opto-fMRI), opto-OISI has the advantage of enabling us to detect responses of small clusters of neurons, even if the clusters are sparsely distributed. We suggest that opto-OISI can be a powerful approach to understanding cognitive function at the neural circuit level, directly linking inter-areal circuitry to fine-scale structure and function.
Ancient amino acids from fossil feathers in amber
Authors: McCoy Victoria E. , Gabbott Sarah E. , Penkman Kirsty , Collins Matthew J. , Presslee Samantha , Holt John , Grossman Harrison , Wang Bo , Solórzano Kraemer Monica M. , Delclòs Xavier , Peñalver Enrique
Published: April 2019

Ancient protein analysis is a rapidly developing field of research. Proteins ranging in age from the Quaternary to Jurassic are being used to answer questions about phylogeny, evolution, and extinction. However, these analyses are sometimes contentious, and focus primarily on large vertebrates in sedimentary fossilisation environments; there are few studies of protein preservation in fossils in amber. Here we show exceptionally slow racemisation rates during thermal degradation experiments of resin enclosed feathers, relative to previous thermal degradation experiments of ostrich eggshell, coral skeleton, and limpet shell. We also recover amino acids from two specimens of fossil feathers in amber. The amino acid compositions are broadly similar to those of degraded feathers, but concentrations are very low, suggesting that much of the original protein has been degraded and lost. High levels of racemisation in more apolar, slowly racemising amino acids suggest that some of the amino acids were ancient and therefore original. Our findings indicate that the unique fossilisation environment inside amber shows potential for the recovery of ancient amino acids and proteins.
Effects of dietary arginine supplementation in pregnant mares on maternal metabolism, placental structure and function and foal growth
Authors: Robles Morgane , Couturier-Tarrade Anne , Derisoud Emilie , Geeverding Audrey , Dubois Cedric , Dahirel Michele , Aioun Josiane , Prezelin Audrey , Calvez Juliane , Richard Christophe , Wimel Laurence , Chavatte-Palmer Pascale
Published: April 2019

Foals born to primiparous mares are lighter and less mature than those born to multiparous dams. Factors driving this difference are not totally understood. Using 7 multiparous and 6 primiparous standardbred mares, we demonstrated that, in late gestation, primiparous mares were less insulin resistant compared to multiparous mares, and that their foals had reduced plasma amino-acid concentrations at birth compared to foals born to multiparous mares. Vascular development, as observed through structure and gene expression, and global DNA methylation were also reduced in primiparous placentas. Another group of 8 primiparous mares was orally supplemented with L-arginine (100 g/day, 210d to term). L-arginine improved pregnancy-induced insulin resistance and increased maternal L-arginine and L-ornithine plasma concentrations but foal plasma amino acid concentrations were not affected at birth. At birth, foal weight and placental biometry, structure, ultra-structure and DNA methylation were not modified. Placental expression of genes involved in glucose and fatty acid transfers was increased. In conclusion, maternal insulin resistance in response to pregnancy and placental function are reduced in primiparous pregnancies. Late-gestation L-arginine supplementation may help primiparous mares to metabolically adapt to pregnancy and improve placental function. More work is needed to confirm these effects and ascertain optimal treatment conditions.
ATP-binding Cassette Transporters Substantially Reduce Estimates of ALDH-positive Cancer Cells based on Aldefluor and AldeRed588 Assays
Authors: Park Jin Won , Jung Kyung-Ho , Byun Youngjoo , Lee Jin Hee , Moon Seung Hwan , Cho Young Seok , Lee Kyung-Han
Published: April 2019

Aldehyde dehydrogenase (ALDH) assays measure the accumulated fluorescence of enzyme products. However, cancer cells frequently co-express ALDH and ATP-binding cassette (ABC) transporters, which might mediate efflux of ALDH assay reagents. We demonstrate expression of active multidrug resistance protein1 (MDR1), multidrug resistance-associated protein (MRP), and breast cancer resistance protein (BCRP) in CT26 cancer cells as well as expression of MRP and BCRP in HT29 cancer cells. Without transporter inhibition, only small portions of both cell types were estimated to be ALDH-positive based on Aldefluor and AldeRed588 assays. However, MK-571 (MRP inhibitor) and novobiocin (BCRP inhibitor) substantially increased the rate of ALDH-positive CT26 cells based on either Aldefluor or AldeRed588 assays. Verapamil (MDR inhibitor) did not influence assay results. MK-571 also substantially increased the rate of ALDH-positive HT29 cells. Limiting dilution assays demonstrated greater numbers of tumor-spheres formed by Aldefluor-positive compared to -negative CT26 cells selected in the presence of MK-571 or novobiocin but not in their absence. These results reveal that Aldefluor and AldeRed588 products are efficient substrates for MRP- and BCRP-mediated efflux and substantially reduce estimated ALDH positivity rates in cancer cells. These findings demonstrate that complete blockade of these transporters is important to ensure accurate ALDH assay results and to develop newer assay techniques.
Resistance to paclitaxel is associated with a variant of the gene BCL2 in multiple tumor types
Authors: Ben-Hamo Rotem , Zilberberg Alona , Cohen Helit , Bahar-Shany Keren , Wachtel Chaim , Korach Jacob , Aviel-Ronen Sarit , Barshack Iris , Barash Danny , Levanon Keren , Efroni Sol
Published: April 2019

Paclitaxel, the most commonly used form of chemotherapy, is utilized in curative protocols in different types of cancer. The response to treatment differs among patients. Biological interpretation of a mechanism to explain this personalized response is still unavailable. Since paclitaxel is known to target BCL2 and TUBB1, we used pan-cancer genomic data from hundreds of patients to show that a single-nucleotide variant in the BCL2 sequence can predict a patient’s response to paclitaxel. Here, we show a connection between this BCL2 genomic variant, its transcript structure, and protein abundance. We demonstrate these findings in silico, in vitro, in formalin-fixed paraffin-embedded (FFPE) tissue, and in patient lymphocytes. We show that tumors with the specific variant are more resistant to paclitaxel. We also show that tumor and normal cells with the variant express higher levels of BCL2 protein, a phenomenon that we validated in an independent cohort of patients. Our results indicate BCL2 sequence variations as determinants of chemotherapy resistance. The knowledge of individual BCL2 genomic sequences prior to the choice of chemotherapy may improve patient survival. The current work also demonstrates the benefit of community-wide, integrative omics data sources combined with in-lab experimentation and validation sets.
Modeling of crop wild relative species identifies areas globally for in situ conservation
Authors: Vincent Holly , Amri Ahmed , Castañeda-Álvarez Nora P. , Dempewolf Hannes , Dulloo Ehsan , Guarino Luigi , Hole David , Mba Chikelu , Toledo Alvaro , Maxted Nigel
Published: April 2019

The impact of climate change is causing challenges for the agricultural production and food systems. More nutritious and climate resilient crop varieties are required, but lack of available and accessible trait diversity is limiting crop improvement. Crop wild relatives (CWR) are the wild cousins of cultivated crops and a vast resource of genetic diversity for breeding new, higher yielding, climate change tolerant crop varieties, but they are under-conserved (particularly in situ), largely unavailable and therefore underutilized. Here we apply species distribution modelling, climate change projections and geographic analyses to 1261 CWR species from 167 major crop genepools to explore key geographical areas for CWR in situ conservation worldwide. We identify 150 sites where 65.7% of the CWR species identified can be conserved for future use.
Population structure determines the tradeoff between fixation probability and fixation time
Authors: Tkadlec Josef , Pavlogiannis Andreas , Chatterjee Krishnendu , Nowak Martin A.
Published: April 2019

The rate of biological evolution depends on the fixation probability and on the fixation time of new mutants. Intensive research has focused on identifying population structures that augment the fixation probability of advantageous mutants. But these amplifiers of natural selection typically increase fixation time. Here we study population structures that achieve a tradeoff between fixation probability and time. First, we show that no amplifiers can have an asymptotically lower absorption time than the well-mixed population. Then we design population structures that substantially augment the fixation probability with just a minor increase in fixation time. Finally, we show that those structures enable higher effective rate of evolution than the well-mixed population provided that the rate of generating advantageous mutants is relatively low. Our work sheds light on how population structure affects the rate of evolution. Moreover, our structures could be useful for lab-based, medical, or industrial applications of evolutionary optimization.
The EC-HDA9 complex rhythmically regulates histone acetylation at the TOC1 promoter in Arabidopsis
Authors: Lee Kyounghee , Mas Paloma , Seo Pil Joon
Published: April 2019

Circadian clocks are conserved time-keeper mechanisms in some prokaryotes and higher eukaryotes. Chromatin modification is emerging as key regulatory mechanism for refining core clock gene expression. Rhythmic changes in histone marks are closely associated to the TIMING OF CAB EXPRESSION 1 (TOC1) Arabidopsis clock gene. However, the chromatin-related modifiers responsible for these marks remain largely unknown. Here, we uncover that the chromatin modifier HISTONE DEACETYLASE 9 (HDA9) and the Evening complex (EC) component EARLY FLOWERING 3 (ELF3) directly interact to regulate the declining phase of TOC1 after its peak expression. We found that HDA9 specifically binds to the TOC1 promoter through the interaction with ELF3. The EC-HDA9 complex promotes H3 deacetylation at the TOC1 locus, contributing to suppressing TOC1 expression during the night, the time of EC function. Therefore, we have identified the mechanism by which the circadian clock intertwines with chromatin-related components to shape the circadian waveforms of gene expression in Arabidopsis.
Gene expression analysis delineates the potential roles of multiple interferons in systemic lupus erythematosus
Authors: Catalina Michelle D. , Bachali Prathyusha , Geraci Nicholas S. , Grammer Amrie C. , Lipsky Peter E.
Published: April 2019

A role for interferon (IFN) in systemic lupus erythematosus (SLE) pathogenesis is inferred from the prominent IFN gene signature (IGS), but the major IFN species and its relationship to disease activity are unknown. A bioinformatic approach employing individual IFN species gene signatures to interrogate SLE microarray datasets demonstrates a putative role for numerous IFN species, with prominent expression of IFNB1 and IFNW signatures. In contrast with other SLE-affected organs, the IGS is less prominent in lupus nephritis. SLE patients with active and inactive disease have readily detectable IGS and the IGS changes synchronously with a monocyte signature but not disease activity, and is significantly related to monocyte transcripts. Monocyte over-expression of three times as many IGS transcripts as T and B cells and IGS retention in monocytes, but not T and B cells from inactive SLE patients contribute to the lack of correlation between the IGS and SLE disease activity.
Perspective and future prospects of tandem olefin oligomerization and Friedel–Crafts alkylation reactions catalyzed by iron, cobalt, nickel and palladium complexes
Authors: Ojwach Stephen O. , Darkwa James
Published: April 2019

Late transition metal complexes in the presence of an EtAlCl2 co-catalyst promote in situ Friedel–Crafts alkylation of preformed olefin oligomers.
Aluminum containing molecular bowls and pyridinophanes: use of pyridine modules to access different molecular topologies
Authors: Bawari Deependra , Negi Chandrakala , Porwal Vishal Kumar , Ravi Satyam , Shamasundar K. R. , Singh Sanjay
Published: April 2019

Bowl shaped organoaluminum bridged neutral and cationic pyridinophanes and aluminum containing neutral bicyclic pyridinophane compounds have been reported.
Structure and luminescence properties of supramolecular polymers of amphiphilic aromatic thioether–peptide conjugates in water
Authors: Ahlers Patrick , Götz Christian , Riebe Steffen , Zirbes Michael , Jochem Matthias , Spitzer Daniel , Voskuhl Jens , Basché Thomas , Besenius Pol
Published: April 2019

We present the preparation of luminophore–peptide conjugates that self-assemble into phosphorescent supramolecular polymers in neutral buffer.
The use of fractionated Kraft lignin to improve the mechanical and biological properties of PVA-based scaffolds
Authors: Rejmontová Petra , Kovalcik Adriana , Humpolíček Petr , Capáková Zdenka , Wrzecionko Erik , Sáha Petr
Published: April 2019

The mechanical properties of poly(vinyl alcohol) (PVA)-based scaffolds were successfully improved.
Forsythiaside inhibited titanium particle-induced inflammation via the NF-κB signaling pathway and RANKL-induced osteoclastogenesis and titanium particle-induced periprosthetic osteolysis via JNK, p38, and ERK signaling pathways
Authors: Xu Kaihang , He Rongzhi , Zhang Yuan , Qin Sheng , Wang Guangchao , Wei Qiang , Zhang Hao , Ji Fang
Published: April 2019

Forsythiaside can act as a candidate drug for the precaution of implant-associated particle-induced osteolysis.
A review of femtosecond laser-structured superhydrophobic or underwater superoleophobic porous surfaces/materials for efficient oil/water separation
Authors: Yong Jiale , Yang Qing , Guo Chunlei , Chen Feng , Hou Xun
Published: April 2019

Recent applications of the femtosecond laser-structured superhydrophobic or underwater superoleophobic porous materials in oil/water separation are summarized in this review.
High-performance metal-oxide thin-film transistors based on inkjet-printed self-confined bilayer heterojunction channels
Authors: Liang Kun , Wang Yan , Shao Shuangshuang , Luo Manman , Pecunia Vincenzo , Shao Lin , Zhao Jianwen , Chen Zheng , Mo Lixin , Cui Zheng
Published: April 2019

High-performance metal-oxide thin-film transistors, based on inkjet-printed self-confined bilayer heterojunction channels.
A resorufin-based fluorescent probe for imaging polysulfides in living cells
Authors: Liu Jingwei , Yin Zheng
Published: April 2019

Nowadays H2Sn have attracted ever-increasing attention in the field of biomedical research. Herein, we report a resorufin-based “turn-on” probe for H2Sn sensing in vitro and in living cells.
Lithium removal from seawater via liquid membrane transport using 12-crown-4 as a carrier and study of the effect of carbon nanotubes as a membrane additive
Authors: Yazdanpanah Mehrdad , Zahedi Mir Mahdi , Ziyaadini Morteza
Published: April 2019

In this work, transport of lithium (Li) ions from seawater into an aqueous phase was performed by using a liquid membrane (LM) and 12-crown-4 as a carrier.
Photocatalyzed borylation using water-soluble quantum dots
Authors: Chandrashekar Hediyala B. , Maji Arun , Halder Ganga , Banerjee Sucheta , Bhattacharyya Sayan , Maiti Debabrata
Published: April 2019

Herein, we report the use of water-soluble MPA-capped quantum dot (QD) photocatalysts for the borylation of diazonium salts in the presence of water.
A deconvolution protocol of the mechanical relaxation spectrum to identify and quantify individual polymer feature contributions to self-healing
Authors: Montano Vincenzo , Picken Stephen J. , van der Zwaag Sybrand , Garcia Santiago J.
Published: April 2019

Deconvolution of overlapping relaxation phenomena in near Tg intrinsic self-healing polymers.
Studies of competing evaporation rates of multiple volatile components from a single binary-component aerosol droplet
Authors: Gregson F. K. A. , Ordoubadi M. , Miles R. E. H. , Haddrell A. E. , Barona D. , Lewis D. , Church T. , Vehring R. , Reid J. P.
Published: April 2019

The simultaneous evaporation and condensation of multiple volatile components from multicomponent aerosol droplets leads to changes in droplet size, composition and temperature.
The influence of zeolite morphology on the conversion of methane to methanol on copper-exchanged omega zeolite (MAZ)
Authors: Knorpp Amy J. , Newton Mark A. , Sushkevich Vitaly L. , Zimmermann Patrik P. , Pinar Ana B. , van Bokhoven Jeroen A.
Published: April 2019

The synthesis conditions and morphology of the zeolite play an enormous role in the direct conversion of methane to methanol.
Nano-sized ZrO2 derived from metal–organic frameworks and their catalytic performance for aromatic synthesis from syngas
Authors: Liu Jingge , He Yurong , Yan Linlin , Li Ke , Zhang Chenghua , Xiang Hongwei , Wen Xiaodong , Li Yongwang
Published: April 2019

Oxygen vacancies apparently improve the surface properties of nano-sized ZrO2, inducing the promotion of the catalytic performance of nano-sized ZrO2.
CO2 electrochemical reduction at thiolate-modified bulk Au electrodes
Authors: Fang Yuxin , Cheng Xun , Flake John C. , Xu Ye
Published: April 2019

Simple modification of polycrystalline bulk Au by an appropriate thiol can selectively enhance electrochemical CO2RR at the expense of HER.
Isolation of chloride- and hydride-bridged tri-iron and -zinc clusters in a tris(β-oxo-δ-diimine) cyclophane ligand
Authors: Hong Dae Ho , Knight Brian J. , Catalano Vincent J. , Murray Leslie J.
Published: April 2019

Chloride- and hydride-bridged tri-iron and -zinc clusters decorated with amine protons were successfully isolated in a cage-type ligand.
Four-membered red iridium(iii) complexes with Ir–S–P–S structures: rapid room-temperature synthesis and application in OLEDs
Authors: Su Ning , Zheng You-Xuan
Published: April 2019

Two pure red iridium(iii) complexes with sulfur-containing ligands were synthesized at room temperature within 5 min, and their devices achieved an EQEmax of 21.50%.
Antifouling UV-treated GO/PES hollow fiber membranes in a membrane bioreactor (MBR)
Authors: Fathizadeh Mahdi , Xu Weiwei L. , Shen Margaret , Jeng Emily , Zhou Fanglei , Dong Qiaobei , Behera Dinesh , Song Zhuonan , Wang Lei , Shakouri Abolfazl , Khivantsev Konstantin , Yu Miao
Published: April 2019

Single layer graphene oxide was studied as a novel coating material to improve the antifouling performance of PES HF membranes in MBR application.
A sulfated polysaccharide fromGracilaria Lemaneiformisregulates cholesterol and bile acid metabolism in high-fat diet mice
Authors: Huang Shiming , Pang Daorui , Li Xiong , You Lijun , Zhao Zhengang , Cheung Peter Chi-Keung , Zhang Mingwei , Liu Dong
Published: April 2019

This study aimed to evaluate the regulation of lipid metabolism and mechanism of a sulfated polysaccharide fromGracilaria Lemaneiformis(GLP).
Ixocarpalactone A from dietary tomatillo inhibits pancreatic cancer growth by targeting PHGDH
Authors: Zheng Mengzhu , Guo Jing , Xu Jiamin , Yang Kaiyin , Tang Ruotian , Gu Xiaoxia , Li Hua , Chen Lixia
Published: April 2019

3-Phosphoglycerate dehydrogenase (PHGDH) has been reported to associate with tumorigenesis in many cancers. IoxA, a natural withanolide obtained from dietary tomatillo (Physalis ixocarpa), was identified as the novel natural PHGDH inhibitor with high targeting and low toxicities for treatment of pancreatic cancers.
Nanocrystalline graphene at high temperatures: insight into nanoscale processes
Authors: Kumar C. N. Shyam , Konrad Manuel , Chakravadhanula Venkata Sai Kiran , Dehm Simone , Wang Di , Wenzel Wolfgang , Krupke Ralph , Kübel Christian
Published: April 2019

In contrast to pristine graphene, nanocrystalline graphene shows a fundamentally different high-temperature behavior due to its reactive nature.
On the passivation of iron particles at the nanoscale
Authors: Lasserus Maximilian , Knez Daniel , Schnedlitz Martin , Hauser Andreas W. , Hofer Ferdinand , Ernst Wolfgang E.
Published: April 2019

The oxidation of Fe@Au core@shell clusters with sizes below 5 nm is studied via high resolution scanning transmission electron microscopy.
Band engineering realized by chemical combination in 2D group VA–VA materials
Authors: Guo Shiying , Zhou Wenhan , Cai Bo , Zhang Kan , Zhang Shengli , Zeng Haibo
Published: April 2019

Theoretical motivation for chemical combination in 2D group VA–VA materials and their novel electronic structures.
Aerobic oxidation of fluorene to fluorenone over Co–Cu bimetal oxides
Authors: Luo Jing , Xuan Keng , Wang Yanxia , Li Feng , Wang Feng , Pu Yanfeng , Li Lei , Zhao Ning , Xiao Fukui
Published: April 2019

Aerobic oxidation of fluorene to fluorenone was achieved over Co–Cu bimetal oxides using O2 as an oxidant in the absence of a radical initiator. Co–Cu bimetal oxides showed better catalytic performance than CuO and Co3O4.
New molecular design for blue BODIPYs
Authors: Wu Zhiyuan , Fujita Hikaru , Magdaong Nikki Cecil M. , Diers James R. , Hood Don , Allu Srinivasarao , Niedzwiedzki Dariusz M. , Kirmaier Christine , Bocian David F. , Holten Dewey , Lindsey Jonathan S.
Published: April 2019

Dihydro analogues of BODIPYs exhibit spectral features (Φf ∼ 0.4–0.9) resembling aminocoumarins and suggest applications for broad-band photosensitization or where large Stokes shifts are desired.
Sulfated zirconia: an efficient catalyst for the Friedel–Crafts monoalkylation of resorcinol with methyl tertiary butyl ether to 4-tertiary butylresorcinol
Authors: Marakatti Vijaykumar S. , Marappa Shivanna , Gaigneaux Eric M.
Published: April 2019

Sulfated zirconia (SZ) is an efficient and recyclable catalyst in the selective monoalkylation of resorcinol with MTBE to 4-tertiary butyl resorcinol at low temperature (60 °C).
Structural determinants of mechanical resistance against breakage of a virus-based protein nanoparticle at a resolution of single amino acids
Authors: Medrano María , Valbuena Alejandro , Rodríguez-Huete Alicia , Mateu Mauricio G.
Published: April 2019

Strength of a virus particle against mechanical breakage is determined by specific chemical groups.
Recyclable nanographene-based micromachines for the on-the-fly capture of nitroaromatic explosives
Authors: Khezri Bahareh , Beladi Mousavi Seyyed Mohsen , Sofer Zdeněk , Pumera Martin
Published: April 2019

A powerful, efficient and fast strategy to remove nitroaromatic explosives using recyclable graphene-based self-propelled tubular micromachines.
Liquid-based memory and artificial synapse
Authors: Kim Dongshin , Lee Jang-Sik
Published: April 2019

Resistive switching is observed in silver nitrate solution and synaptic behaviors are evaluated using liquid-based memory devices.
Insights into the thermal and chemical stability of multilayered V2CTx MXene
Authors: Thakur Raj , VahidMohammadi Armin , Moncada Jorge , Adams William R. , Chi Mingyang , Tatarchuk Bruce , Beidaghi Majid , Carrero Carlos A.
Published: April 2019

We report the thermal stability of multilayered V2CTx MXene by combining various techniques to elucidate and monitor the molecular, electronic, and structural changes in the material.
Fusaresters A–E, new γ-pyrone-containing polyketides from fungusFusariumsp. Hungcl and structure revision of fusariumin D
Authors: Gong Jiaojiao , Chen Chunmei , Mo Shuyuan , Liu Junjun , Wang Wenjing , Zang Yi , Li Huaqiang , Chai Chenwei , Zhu Hucheng , Hu Zhengxi , Wang Jianping , Zhang Yonghui
Published: April 2019

Chemical investigation of a marine-derived fungusFusariumsp. Hungcl afforded five new γ-pyrone-containing polyketides, fusaresters A–E.
Nanopore separator of cross-linked poly(propylene glycol)-co-pentaerythritol triacrylate for effectively suppressing polysulfide shuttling in Li–S batteries
Authors: Li Haixia , Tang Wentao , Huang Yifu , Ruan Wenhong , Zhang Mingqiu
Published: April 2019

A nanopore polymer separator blocks the polysulfide migration more efficiently than the Celgard separator, endowing a Li–S battery with a much better discharge performance.
Controlled aggregation of core(amorphous silica)@shell(TPA+-polysilicate) nanoparticles at room temperature by selective removal of TPA+ ions from the nanoparticle shell
Authors: Bosnar Sanja , Sikirić Maja Dutour , Smrečki Vilko , Bronić Josip , Šegota Suzana , Strasser Vida , Antonić Jelić Tatjana , Palčić Ana , Subotić Boris
Published: April 2019

Displacement of TPA+ ions from the nanoparticle shell exposes the terminal silanol groups, which enables the aggregation of the collided nanoparticles.
Enhanced thermoelectric transport properties of n-type InSe due to the emergence of the flat band by Si doping
Authors: Lee Kyu Hyoung , Oh Min-Wook , Kim Hyun-Sik , Shin Weon Ho , Lee Kimoon , Lim Jae-Hong , Kim Ji-il , Kim Sang-il
Published: April 2019

An improved thermoelectric figure of merit (zT) of 0.14 at 795 K was obtained in 7% Si doped InSe due to the emergence of the flat band.
Facile and scalable preparation of 3D SnO2/holey graphene composite frameworks for stable lithium storage at a high mass loading level
Authors: Liang Junfei , Sun Hongtao , Xu Yuqi , Liu Tengxiao , Wang Hua , Liu Hantao , Guo Lin
Published: April 2019

A binder-free 3D SnO2/holey graphene composite framework electrode with high mass loading shows superior Li+ storage performance.
Enhanced catalytic degradation of amoxicillin with TiO2–Fe3O4 composites via a submerged magnetic separation membrane photocatalytic reactor (SMSMPR)
Authors: Li Qilong , Kong Hui , Jia Rongrong , Shao Jiahui , He Yiliang
Published: April 2019

With a TiO2–Fe3O4 composite as the catalyst, amoxicillin was degraded via a photo-Fenton process using a submerged magnetic separation membrane photocatalytic reactor.
Self-assembly of l-phenylalanine amino acid: electrostatic induced hindrance of fibril formation
Authors: Tomar Deepak , Chaudhary Shilpi , Jena Kailash Chandra
Published: April 2019

Nanostructure morphology originating from the self-assembly of molecules has attracted substantial attention due to its role in toxic amyloid fibril formation and immense potential in the design and fabrication of novel biomaterials.
Computational investigation of the Mg-ion conductivity and phase stability of MgZr4(PO4)6
Authors: Nakano Koki , Noda Yusuke , Tanibata Naoto , Nakayama Masanobu , Kajihara Koichi , Kanamura Kiyoshi
Published: April 2019

Computational studies on Mg ion conduction in the MgZr2(PO4)6 with both NASICON-type and β sulfate-type structures have been performed.
Bilayer MSe2 (M = Zr, Hf) as promising two-dimensional thermoelectric materials: a first-principles study
Authors: Yan Peng , Gao Guo-ying , Ding Guang-qian , Qin Dan
Published: April 2019

Motivated by experimental synthesis of two-dimensional MSe2 (M = Zr, Hf) thin films, we investigate the thermoelectric transport properties of MSe2 (M = Zr, Hf) bilayers by using first-principles calculations and Boltzmann transport theory.
Nanostructured poly(l-lactic acid)–poly(ethylene glycol)–poly(l-lactic acid) triblock copolymers and their CO2/O2permselectivity
Authors: Xueyan Yun , Xiaofang Li , Pengju Pan , Tungalag Dong
Published: April 2019

Biodegradable PLLA copolymers, containing higher molecular weight and content of PEG present better CO2permeability and CO2/O2permselectivity, have great potential for use as fresh product packaging.
Construction of a graphene/polypyrrole composite electrode as an electrochemically controlled release system
Authors: Zhu Mo , Hao Ying , Ma Xun , Feng Lin , Zhai Yuanxin , Ding Yaping , Cheng Guosheng
Published: April 2019

A biocompatible conductive composite electrode GN–PPy–FL can realize controlled release of a drug model triggered by low voltages.
Fabrication of polyaniline–graphene/polystyrene nanocomposites for flexible gas sensors
Authors: Bhadra Jolly , Popelka Anton , Abdulkareem Asma , Ahmad Zubair , Touati Farid , Al-Thani Noora
Published: April 2019

A flexible thin membrane made of a graphene–PANI nanocomposite decorated PS electrospun fibre as a highly sensitive carbon dioxide gas sensor.
Annealing atmosphere effect on the resistive switching and magnetic properties of spinel Co3O4 thin films prepared by a sol–gel technique
Authors: Yao Chuangye , Ismail Muhammad , Hao Aize , Thatikonda Santhosh Kumar , Huang Wenhua , Qin Ni , Bao Dinghua
Published: April 2019

The resistive switching and magnetic properties can be enhanced by controlling oxygen vacancies via the annealing atmosphere effect.
Fabrication and excellent electroresponsive properties of ideal PMMA@BaTiO3 composite particles
Authors: Liu Wen , Xie Zunyuan , Lu Yaping , Gao Meixiang , Zhang Weiqiang , Gao Lingxiang
Published: April 2019

A series of core–shell-structured poly(methylmethacrylate)@BaTiO3 (PMMA@BT) composite particles were constructed via the self-assembly of BT nanoparticles on the surfaces of PMMA cores through the covalent bonding of siloxane groups at room temperature.
Eco-friendly and facile one-step synthesis of a three dimensional net-like magnetic mesoporous carbon derived from wastepaper as a renewable adsorbent
Authors: Yu Jing , Zhang Donghuan , Zhu Shukui , Chen Pin , Zhu Gang-Tian , Jiang Xiangtao , Di Siyuan
Published: April 2019

Millions of tons of paper and its derivatives are annually wasted without being recycled and reused.
Transport property of ligand-driven light-induced spin-change Fe-based spin crossover complexes
Authors: Li Feifei , Huang Jing , Hu Yujie , Li Qunxiang
Published: April 2019

The transport properties of LD-LISC Fe-based SCO complexes with the trans and cis configuration exhibit robust spin-filtering and NDR features, which highlight them for promising applications in molecular devices.
Black titania nanotubes/spongy graphene nanocomposites for high-performance supercapacitors
Authors: El-Gendy Dalia M. , Abdel Ghany Nabil A. , Allam Nageh K.
Published: April 2019

A simple method is demonstrated to prepare functionalized spongy graphene/hydrogenated titanium dioxide (FG-HTiO2) nanocomposites as interconnected, porous 3-dimensional (3D) network crinkly sheets.
Importance of protein flexibility in ranking ERK2 Type I1/2inhibitor affinities: a computational study
Authors: Niu Yuzhen , Yao Xiaojun , Ji Hongfang
Published: April 2019

Extracellular-regulated kinase (ERK2) has been regarded as an essential target for various cancers, especially melanoma.
Mesoporous carbon prepared by etching halloysite nanotubes (HNTs) with pyrrole as a precursor for a sulfur carrier of superior lithium–sulfur batteries
Authors: Liu Jiuqing , Wang Cheng , Cui Jinqiang , Li Jie , Li Qihou , Liu Meng , Xi Yang
Published: April 2019

Using pyrrole as a carbon precursor and halloysite nanotubes (HNT) as a templating agent, mesoporous carbon (MC) was prepared by template etching and combined with sulfur as a composite cathode for lithium–sulfur batteries.
Solving the enigma of weak fluorine contacts in the solid state: a periodic DFT study of fluorinated organic crystals
Authors: Levina Elena O. , Chernyshov Ivan Y. , Voronin Alexander P. , Alekseiko Leonid N. , Stash Adam I. , Vener Mikhail V.
Published: April 2019

The nature and strength of weak C–H⋯F–C and C–F⋯F–C interactions and their role in organofluorine molecular crystals were studied using periodic DFT coupled with CSD data mining and experimental sublimation enthalpies.
Monitoring spin coherence of single nitrogen-vacancy centers in nanodiamonds during pH changes in aqueous buffer solutions
Authors: Fujiwara Masazumi , Tsukahara Ryuta , Sera Yoshihiko , Yukawa Hiroshi , Baba Yoshinobu , Shikata Shinichi , Hashimoto Hideki
Published: April 2019

We report on the sensing stability of quantum nanosensors in aqueous buffer solutions for the two detection schemes of quantum decoherence spectroscopy and nanoscale thermometry.
Synthesis of block cationic polyacrylamide precursors using an aqueous RAFT dispersion polymerization
Authors: Huang Bo , Jiang Jie , Kang Mutian , Liu Pingwei , Sun Hailong , Li Bo-Geng , Wang Wen-Jun
Published: April 2019

Synthesis of block cationic polyacrylamides (CPAMs) by introducing random CPAM as both chain-transfer agent and stabilizer for aqueous RAFT dispersion polymerization of acrylamide is a promising approach for engineering high-performance CPAMs.
Reaction pathways and kinetics for tetra-alanine in hot, compressed liquid water
Authors: Sheehan James D. , Abraham Ashwin , Savage Phillip E.
Published: April 2019

pH alters the prevalence of the dissociation states of peptides, through acid–base equilibrium, and influences reaction selectivity under hydrothermal conditions.
Harnessing13C-labeledmyo-inositol to interrogate inositol phosphate messengers by NMR
Authors: Harmel Robert K. , Puschmann Robert , Nguyen Trung Minh , Saiardi Adolfo , Schmieder Peter , Fiedler Dorothea
Published: April 2019

The analysis of inositol poly- and pyrophosphates, an important group of eukaryotic messengers, is enabled by applying13C-labeled inositol.
A synthetic cyclitol-nucleoside conjugate polyphosphate is a highly potent second messenger mimic
Authors: Dohle Wolfgang , Su Xiangdong , Mills Stephen J. , Rossi Ana M. , Taylor Colin W. , Potter Barry V. L.
Published: April 2019

A densely functionalised phosphorylatedchiro-inositol-nucleoside ether conjugate constructed from cyclic fragments is the most potent IP3receptor ligand discovered.
Nitrogen-coordinated cobalt nanocrystals for oxidative dehydrogenation and hydrogenation of N-heterocycles
Authors: Wu Yue , Chen Zheng , Cheong Weng-Chon , Zhang Chao , Zheng Lirong , Yan Wensheng , Yu Rong , Chen Chen , Li Yadong
Published: April 2019

To endow non-noble metals with the high catalytic activity that is typically exhibited by noble metals is the central yet challenging aim for substituting noble metals.
Guest recognition enhanced by lateral interactions
Authors: Jiao Tianyu , Cai Kang , Liu Zhichang , Wu Guangcheng , Shen Libo , Cheng Chuyang , Feng Yuanning , Stern Charlotte L. , Stoddart J. Fraser , Li Hao
Published: April 2019

Lateral interactions enhance the guest inclusion and peripheral complexation within a highly charged covalent cage.
Quantifying rival bond fission probabilities following photoexcitation: C–S bond fission in t-butylmethylsulfide
Authors: Bain Matthew , Hansen Christopher S. , Karsili Tolga N. V. , Ashfold Michael N. R.
Published: April 2019

Competitive bond fission probabilities in a photoexcited molecule are quantified using contemporary ion imaging methods.
Tuning the π-bridge of quadrupolar triarylborane chromophores for one- and two-photon excited fluorescence imaging of lysosomes in live cells
Authors: Griesbeck Stefanie , Michail Evripidis , Wang Chenguang , Ogasawara Hiroaki , Lorenzen Sabine , Gerstner Lukas , Zang Theresa , Nitsch Jörn , Sato Yoshikatsu , Bertermann Rüdiger , Taki Masayasu , Lambert Christoph , Yamaguchi Shigehiro , Marder Todd B.
Published: April 2019

The tetracationic diketopyrrolopyrrole compound 5M exhibits a σ2 value of 4560 GM at 740 nm.
Threading-gated photochromism in [2]pseudorotaxanes
Authors: Baggi Giorgio , Casimiro Lorenzo , Baroncini Massimo , Silvi Serena , Credi Alberto , Loeb Stephen J.
Published: April 2019

Photochromic axles bearing a bis(thienyl)ethene moiety exhibit threading-gated photochromism, where formation of a [2]pseudorotaxane with crown ether rings significantly enhances the photochromic properties of the axles.
Synergistic effect of N-doped layered double hydroxide derived NiZnAl oxides in CO2 electroreduction
Authors: Li Wenting , Hou Pengfei , Wang Zhuo , Kang Peng
Published: April 2019

N-doped NiZnAl oxides on graphene which were derived from layered double hydroxide showed a synergistic effect in CO2 electrocatalytic reduction to CO.
Impact of perovskite solar cell degradation on the lifetime energy yield and economic viability of perovskite/silicon tandem modules
Authors: Qian Jiadong , Ernst Marco , Wu Nandi , Blakers Andrew
Published: April 2019

Perovskite/silicon two-junction tandem solar cells have achieved higher power conversion efficiency than silicon cells. However, the long-term performance of tandem modules strongly depends on the degradation of perovskite top cells.
Poly(3-hexylthiophene)/zinc phthalocyanine composites for advanced interface engineering of 10.03%-efficiency CsPbBr3 perovskite solar cells
Authors: Liu Yu , He Benlin , Duan Jialong , Zhao Yuanyuan , Ding Yang , Tang Mixue , Chen Haiyan , Tang Qunwei
Published: April 2019

Through passivating and promoting interfacial charge extraction, P3HT/ZnPc composite HTMs help CsPbBr3 PSC achieve a champion PCE of 10.03% and excellent stability.
Boosting the pseudocapacitance of nitrogen-rich carbon nanorod arrays for electrochemical capacitors
Authors: Yang Duo , Song Yu , Ye Yin-Jian , Zhang Mingyue , Sun Xiaoqi , Liu Xiao-Xia
Published: April 2019

The ultrahigh N content (∼24%) induced by the low-temperature treatment boosts the pseudocapacitance for carbonaceous materials.
Efficient and stable carbon-based perovskite solar cells enabled by the inorganic interface of CuSCN and carbon nanotubes
Authors: Wu Xin , Xie Liqiang , Lin Kebin , Lu Jianxun , Wang Kexiang , Feng Wenjing , Fan Bingbing , Yin Penggang , Wei Zhanhua
Published: April 2019

The inorganic CuSCN interlayer makes carbon-based perovskite solar cells more efficient and stable.
A negatively charged Pt(iv) prodrug for electrostatic complexation with polymers to overcome cisplatin resistance
Authors: Kang Xiaoxu , Yu Yingjie , Chen Zhigang , Wu Yixin , Wei Dengshuai , Zhao Yao , Wang Fuyi , Xiao Haihua
Published: April 2019

A negatively charged Pt(iv) prodrug with lipid tails can self-assemble into nanoparticles via electrostatic complexation with a positively charged hydrophilic polymer, which exhibits great potential for clinical application.
Mussel-inspired coatings with tunable wettability, for enhanced antibacterial efficiency and reduced bacterial adhesion
Authors: Li Mingjun , Schlaich Christoph , Willem Kulka Michaël , Donskyi Ievgen S. , Schwerdtle Tanja , Unger Wolfgang E. S. , Haag Rainer
Published: April 2019

The mussel-inspired coatings with tunable wettability were designed, showing enhanced antibacterial efficiency and reduced bacterial adhesion.
Sol–gel magnetite inks for inkjet printing
Authors: Kolchanov Denis S. , Slabov Vladislav , Keller Kirill , Sergeeva Ekaterina , Zhukov Mikhail V. , Drozdov Andrey S. , Vinogradov Alexandr V.
Published: April 2019

The article describes an easy-to-implement and print-ready composition for inkjet printing of magnetic structures, which can be used for security printing, coding, and marking, magnetic device fabrication or creation of micro-antennas.
Efficient perovskite solar cells with negligible hysteresis achieved by sol–gel-driven spinel nickel cobalt oxide thin films as the hole transport layer
Authors: Lee Ju Ho , Noh Young Wook , Jin In Su , Park Sang Hyun , Jung Jae Woong
Published: April 2019

Current–voltage hysteresis is a critical issue that impacts the photovoltaic performance of perovskite solar cells, and thus, it is imperative to develop high-efficiency perovskite solar cells without hysteresis behavior.
Radiative emission from Cu2ZnSnS4/ZnSn core/shell nanocrystals
Authors: Irkhina A. , Levcenko S. , Xie L. , Leifer K. , Unold T.
Published: April 2019

The authors experimentally demonstrate that passivation of the Cu2ZnSnS4nanocrystals by a ZnSn shell can activate the radiative emission.
Liquid metals for tuning gas sensitive layers
Authors: Han Jialuo , Yang Jiong , Tang Jianbo , Ghasemian Mohammad B. , Hubble Lee J. , Syed Nitu , Daeneke Torben , Kalantar-Zadeh Kourosh
Published: April 2019

Liquid metals can offer extraordinary properties for application in the field of sensors, yet their potential has not been fully realised.
Efficacy and toxicities of combination maintenance therapy in the treatment of advanced non-small-cell lung cancer: an up-to-date meta-analysis
Authors: Hu Jianming , Hu Jiawei , Liu Xiaolan , Li Long , Bai Xue
Published: April 2019

Background: Single agent maintenance therapy has been approved for the treatment of advanced non-small-cell lung cancer (NSCLC) due to its potential survival benefits, but whether combined maintenance therapy would improve the survival of advanced NSCLC remains undetermined.

Methods: Relevant trials were identified by searching electronic databases and conference meetings. Prospective randomized controlled trials (RCTs) assessing combination maintenance therapy in advanced NSCLC patients were included. Outcomes of interest included overall survival (OS), progression-free survival (PFS), and grade 3–4 toxicities.

Results: A total of 1950 advanced NSCLC patients received combination maintenance treatment from six trials were included for analysis. The use of doublet maintenance therapy in NSCLC patients significantly improved PFS (HR 0.74, 95%CI: 0.59–0.93, P = 0.010), but not for OS (HR 0.95, 95%CI: 0.85–1.07, P = 0.40) in comparison with single agent maintenance therapy. Similar results were observed in sub-group analysis according to treatment regimens. In addition, there was no significantly risk difference between doublet and single agent maintenance therapy in terms of grade 3/4 hematologic and non-hematologic toxicities.

Conclusion: The findings of the present study show that doublet combination maintenance therapy is superior to single agent maintenance therapy in terms of PFS, without increased grade 3–4 toxicities. Future prospective studies are recommended to clearly assess the long-term clinical benefit of doublet maintenance therapy and its impact on health-related quality of life.
Datenschutzkonform arbeiten – Praxistipps für Hebammen zur DSGVO
Authors: Diefenbacher Matthias
Published: April 2019

Seit 25.05.2018 gilt die neue Datenschutz-Grundverordnung (DSGVO) in der gesamten Europäischen Union. Sie ist geltendes Recht (Art. 3 I, alle im Folgenden genannten Artikel sind solche der DSGVO). Das bringt einige Neuerungen auch für Hebammen mit sich und hat Auswirkungen auf die tägliche Praxis, insbesondere im Hinblick auf die Schweigepflicht und berufsrechtliche Regelungen. Welche Vorgaben einzuhalten sind, verrät dieser Artikel.
Die Angst junger Erwachsener vor Schwangerschaft und Geburt
Authors: Streffing Joana , Stoll Kathrin , Gross Mechthild M.
Published: April 2019

Schwangerschaft und Geburt gehören zu den sensibelsten Phasen im Leben einer Frau und dem ihrer Begleitperson. Die Kenntnis über mögliche Ängste ist für das geburtshilfliche Personal wichtig, um eine gute und adäquate Betreuung gewährleisten zu können. Daher erhob die vorliegende Masterarbeit die Angst junger Erwachsener vor Schwangerschaft und Geburt. Zudem analysierte sie, wie die Befragten Informationen über Schwangerschaft und Geburt erhalten haben und wie dies optimiert werden kann.
Interdisziplinäre Betreuung von Schwangeren mit schweren internistischen Vorerkrankungen
Authors: Schäfer-Graf Ute
Published: April 2019

Schwangere mit schwerwiegenden internistischen Vorerkrankungen stellen eine Risikogruppe von zunehmender Größe dar, die einer engen interdisziplinären Betreuung bedarf. Der Beitrag vermittelt die wichtigsten Hintergründe für die häufigsten Erkrankungen und erklärt anhand des Vorgehens am St. Joseph Krankenhaus in Berlin, wie eine abgestimmte Beratung und Behandlung umgesetzt werden kann. Hebammen tragen durch die emotionale Entlastung und fachliche Unterstützung der Schwangeren wesentlich dazu bei, Schwangerschaftsverlauf und Geburt positiv zu gestalten.