bluuebunny/crossref_metadata_2025 huggingface dataset:
Separation of Oral Cooling and Warming Requires TRPM8
Authors: Li Jinrong , Zumpano Kyle T. , Lemon Christian H.
Published: February 2024

Cooling sensations arise inside the mouth during ingestive and homeostasis behaviors. Oral presence of cooling temperature engages the cold and menthol receptor TRPM8 (transient receptor potential melastatin 8) on trigeminal afferents. Yet, how TRPM8 influences brain and behavioral responses to oral temperature is undefined. Here we used in vivo neurophysiology to record action potentials stimulated by cooling and warming of oral tissues from trigeminal nucleus caudalis neurons in female and male wild-type and TRPM8 gene deficient mice. Using these lines, we also measured orobehavioral licking responses to cool and warm water in a novel, temperature-controlled fluid choice test. Capture of antidromic electrophysiological responses to thalamic stimulation identified that wild-type central trigeminal neurons showed diverse responses to oral cooling. Some neurons displayed relatively strong excitation to cold <10°C (COLD neurons) while others responded to only a segment of mild cool temperatures below 30°C (COOL neurons). Notably, TRPM8 deficient mice retained COLD-type but lacked COOL cells. This deficit impaired population responses to mild cooling temperatures below 30°C and allowed warmth-like (≥35°C) neural activity to pervade the normally innocuous cool temperature range, predicting TRPM8 deficient mice would show anomalously similar orobehavioral responses to warm and cool temperatures. Accordingly, TRPM8 deficient mice avoided both warm (35°C) and mild cool (≤30°C) water and sought colder temperatures in fluid licking tests, whereas control mice avoided warm but were indifferent to mild cool and colder water. Results imply TRPM8 input separates cool from warm temperature sensing and suggest other thermoreceptors also participate in oral cooling sensation.
Edge-Based General Linear Models Capture Moment-to-Moment Fluctuations in Attention
Authors: Jones Henry M. , Yoo Kwangsun , Chun Marvin M. , Rosenberg Monica D.
Published: February 2024

Although we must prioritize the processing of task-relevant information to navigate life, our ability to do so fluctuates across time. Previous work has identified fMRI functional connectivity (FC) networks that predict an individual's ability to sustain attention and vary with attentional state from 1 min to the next. However, traditional dynamic FC approaches typically lack the temporal precision to capture moment-to-moment network fluctuations. Recently, researchers have “unfurled” traditional FC matrices in “edge cofluctuation time series” which measure timepoint-by-timepoint cofluctuations between regions. Here we apply event-based and parametric fMRI analyses to edge time series to capture moment-to-moment fluctuations in networks related to attention. In two independent fMRI datasets examining young adults of both sexes in which participants performed a sustained attention task, we identified a reliable set of edges that rapidly deflects in response to rare task events. Another set of edges varies with continuous fluctuations in attention and overlaps with a previously defined set of edges associated with individual differences in sustained attention. Demonstrating that edge-based analyses are not simply redundant with traditional regions-of-interest–based approaches, up to one-third of reliably deflected edges were not predicted from univariate activity patterns alone. These results reveal the large potential in combining traditional fMRI analyses with edge time series to identify rapid reconfigurations in networks across the brain.
The Use of Management Information System Direct Procurement (SIMPEL) in the Procurement of Goods and Services within the Ministry of Education, Culture, Research, and Technology
Authors: Yuwono Setyo , Masdjojo Gregorius N.
Published: February 2024

The research objective is to identify and analyze the effect of performance expectancy, effort expectancy, and social influence on behavior intention within the Ministry of Education, Culture, Research, and Technology. To find out and analyze the effect of facilitating conditions and behavior intention on user behavior within the Ministry of Education, Culture, Research, and Technology. The research population is SIMPeL users within the Ministry of Education, Culture, Research, and Technology, totaling 60 people. The sampling technique with census sampling technique is to determine the number of samples by taking all members of the existing population to be sampled so that the sample size is 60 respondents. The data used is primary data in the form of a questionnaire. Data analysis used linear regression analysis. The results of the performance expectancy research have a positive and significant effect on behavior intention. Effort expectancy has a positive and significant effect on behavior intention. Social influence has a positive and significant effect on behavior intention. Facilitating conditions have a positive and significant effect on user behavior. The behavioral intention has a positive and significant effect on user behavior. Behavioral intention does not mediate the influence between performance expectancy on behavioral use. Behavioral intention mediates the influence between effort expectancy on behavioral use. Behavioral intention mediates the influence between social influence on behavioral use.
The Tiroca Model of PT Goto Gojek Tokopedia Tbk
Authors: Priscilla Lysandra , Khoirunissa Alvi Diani , Rufaidah Popy
Published: February 2024

This research aims to analyze the strategy of PT GoTo Gojek Tokopedia Tbk. by using the TIROCA model (Tangible, Intangible Resources, and Organizational Capabilities Analysis) as a basis for identifying the company's strengths and weaknesses. This research uses the qualitative research method with a case study approach to explore the company's strategic strengths and weaknesses through tangible assets, intangible assets, and organizational capabilities. The results showed that the company's sustainable competitive advantage comes from technology as a tangible resource, brand reputation as an intangible resource, and the company's ability to manage product development and improve the quality of human resources as an organizational resource capability. This research contributes to expanding the understanding of PT GoTo's business strategy and provides advice for making the right decisions in developing the business in the future.
Information Technology Capabilities and Innovation Capacities Increasing with Competitive Advantage
Authors: HENDRAYANTI SILVIA , Fauziyanti Wachidah , Tamrin Moh
Published: February 2024

This study aims to examine the effect of information technology capability and innovation capability on culinary UMKM competitive advantage with strategy as an intervening variable. This research was conducted in the city of Semarang. The sampling technique used purposive sampling method. The research data is primary data collected by distributing questionnaires to UMKM owners in the culinary field in Semarang City with a sample of 96 respondents. Hypothesis testing is done using the Path Analysis method. Based on statistical tests, the results show that information technology capability has a significant effect on strategy, innovation capability has a significant effect on strategy, information technology capability has a significant effect on competitive advantage. Innovation capability has a significant effect on competitive advantage, and Strategy has a significant effect on competitive advantage. Micro, small and medium businesses in the culinary field It is suggested to be able to continue to increase the use of information technology in order support business activities and improve the ability to create innovation in product without losing the original product.
The Funding Burden in Detecting Financial Fraud
Authors: Utomo Sasongko Tri , Mawardi Wisnu
Published: February 2024

The purpose of this research is to analyze the relationship between Leverage, financial performance and earnings manipulation. The Leverage in this study uses a debt to total asset (DART) proxy, while for financial performance it uses a return on asset (ROA) proxy. Manipulation decisions with the beneficial M score model where the results will be seen by companies in the manipulator or non-manipulator category. This study used a sample of manufacturing companies listed on the Indonesia Stock Exchange for the 2016 – 2020 period. The sample was taken using a purposive sampling technique and the number of samples used was 29 companies so the data analyzed was 145 data. The analytical method used is path analysis with SPSS software. These findings indicate that Leverage has a significant negative effect on financial performance. Financial performance has a positive effect on earnings manipulation and financial performance mediates a significant positive relationship between leverage and earnings manipulation. The results of these findings can be used as that for regulators, management, policy makers, government agencies (Financial Services Authority and the Indonesian Stock Exchange) in making procedures or developing a policy that is able to control or closely supervise companies in transparency of the company's financial condition so as to minimize companies committing fraud. financial Manipulation. In addition, this research is still rarely researched because many previous studies have focused on reporting quality, earnings management, financial fraud with proxies other than M Score so that to the author's knowledge no one has researched with a focus on earnings manipulation
Does Innovation Matter? Evidence from Enterprise Survey of ASEAN Countries
Authors: Fuad Muhammad , Purnamasari Shresta , Maksar Muhammad Sofian
Published: February 2024

This study embarks on an investigation to unearth evidence that innovation may, in certain contexts, fail to foster enterprise development. Innovation has been identified as a key driver of firms’ growth. However, to have successful innovation requires some minimum capabilities and resources. Based on this notion, we tried to find evidence that innovation may fail to help enterprises develop. The study use the World Bank's enterprise survey. The survey collected samples from ASEAN firms. Respondents were chosen by using stratified random sampling technique based on the type of business for all small, medium and large non-agricultural companies in all geographical areas. We used instrumental variable regression to avoid simultaneous causality. The findings show that while innovation has a considerable impact on the growth of non-SMEs, it has little or no impact on SMEs. This confirms our prediction that innovation dampen firms’ development, particularly those with limited abilities to innovate successfully. The research emphasizing the importance of tailored approaches to accommodate the diverse landscape of businesses, particularly in the dynamic ASEAN market.
Aportes inéditos en la biografía y carrera del artista Eulogio Varela Sartorio (1868-1955). Circunstancias y acontecimientos de sus últimos años a la luz del archivo familiar
Authors: Aparicio Benítez Antonio José
Published: February 2024

Eulogio Varela Sartorio (1868-1955), ilustrador gráfico, pintor y artista polifacético, ha sido objeto de diversos estudios que, sin embargo, han dejado hasta la fecha no pocas interrogantes, fundamentalmente sobre el final de su vida. Este artículo pretende despejar alguna de esas cuestiones, aportando un nuevo marco documental y factual que ayude a delimitar un perfil biográfico más definido de su figura, así como un inédito hilo de sucesos que marcarían la vejez del maestro. La investigación se sustenta en el estudio y cotejo de los numerosos documentos pertenecientes al archivo familiar que, al margen de aclararnos diferentes aspectos de sus últimos años, descubren también ciertos datos profesionales y personales desconocidos.
Beating and the Mechanical Properties of Paper
Authors:   PAPER TECHNOLOGY DEPT., SWEDISH FOREST PRODUCTS RESEARCH LABORATORY, STOCKHOLM, Steenberg Borje
Published: February 2024

A survey of existing standard and suggested methods of paper testing shows the need of increasing the battery of testing methods to enable a more thorough theoretical analysis of the influence of beating on mechanical properties of paper to be made. This statement is exemplified among others by a comparison of the vast quantity of scientific work on beating carried out using the Mullen tester and the small amount of new information reached over a period of years. Only by using methods sufficiently well defined to allow physical interpretation either alone or in combination with other tests can a comprehensible theory of the influence of beating on paper properties be expected. The problem of studying beating is complicated by the fact that there seems to be no method by which all fibres in a sample can be treated in the same way. Fibre length determinations as a measure of beating have limitations. The important property of fibre flexibility ought to be made the subject of closer study and a possible way of carrying out such studies is indicated. The need to study the stress distribution in paper under different conditions in order to understand its behaviour and the influence of its composition is stressed. The problem is in all probability so complicated that any valuable theory must be supposed to include a number of independent factors.
Enhancing Patient Safety and Financial Performance: Business Management Strategies for Reducing Medical Errors in Healthcare Organizations
Authors: Malkawi Ruba , Al-karaki Wa’el , Tawalbeh Mohammad , Gharaibeh Sara , Tawalbeh Jawad
Published: February 2024

This research article explores the crucial role of effective strategies in reducing medical errors and improving profitability in healthcare organizations. Medical errors pose a significant threat to patient safety and also result in substantial financial burdens. By implementing comprehensive approaches and leveraging business management techniques, healthcare organizations can enhance patient safety while simultaneously achieving financial stability. This study examines various strategies such as optimizing workflow, minimizing distractions, ensuring proper drug storage, implementing rigorous prescription checking processes, and providing thorough patient counseling. Moreover, it emphasizes the significance of organizational culture, adequate staffing, and workload balancing in reducing medical errors. The findings underscore the importance of a system-oriented approach and the involvement of business managers in fostering a culture of safety and implementing cost-effective measures. This research aims to provide healthcare leaders and managers with valuable insights and evidence-based recommendations to guide their efforts in reducing medical errors and improving the overall profitability of healthcare organizations.
Apibrėžtumas ir jo raiška romanų kalbose: tipologinis ir diachroninis aspektai
Authors:   , Keturakis Antanas
Published: February 2024

Definiteness and its marking in Romance languages: typological and diachronic aspects
Parental Mental Illness and the Likelihood of Child Out-of-Home Care: A Cohort Study
Authors: Nevriana Alicia , Kosidou Kyriaki , Hope Holly , Wicks Susanne , Dalman Christina , Pierce Matthias , Abel Kathryn M.
Published: February 2024

OBJECTIVES

To detail the relationship between parental mental illness and the likelihood of out-of-home care (OHC) among their children, and to identify factors which modify this relationship.

METHODS

Using Swedish national registers, children born in 2000 to 2011 (n = 1 249 463) were linked to their parents. Time-dependent parental mental illness (nonaffective and affective psychosis, substance misuse, depression, anxiety and stress, eating disorders, personality disorders, attention deficit hyperactivity disorder, autism, and intellectual disability), was identified through International Classification of Diseases codes.

RESULTS

After adjustment for socioeconomic factors, children living with mentally ill parents were 4 times as likely to be placed in OHC than children without (95% confidence interval [CI] 4.24–4.61). The highest hazard ratio (HR) was in the youngest children aged 0 to 1 year (5.77, 95% CI 5.42–6.14), exposed to maternal illness (HR 4.56, 95% CI 4.37–4.76), and parental intellectual disability (HR 4.73, 95% CI 4.09–5.46). Children with parental mental illness with multiple risk factors were at particularly high risk. Compared with children without parental mental illness, and those with university-educated parents, children whose parents had mental illness and only had education to age 16 had a 15 times higher risk of OHC (95% CI 13.75–16.54).

CONCLUSIONS

Children with parental mental illness are considerably more likely to be removed from home into care during childhood, particularly during the first year of life and if they are from socially disadvantaged families. Greater knowledge of these risks should lead to increased support for vulnerable new families.
Performance of agri-food organizations in the Colombian Central Region supplying food to Bogotá
Authors: Delgado-López Miguel Augusto , Barrientos-Fuentes Juan Carlos , Barrios Dursun
Published: February 2024

The city of Bogotá requires approximately 2.7 million t of food products annually, of which 84% comes from the territories associated with the Central Region of the country (Bogotá, Boyacá, Cundinamarca, Meta, and Tolima). Small agricultural producers, who supply food to the main urban centers through intermediaries, are now targeted by a new marketing strategy promoted by the district. The objective of this strategy is to transform agroredes (organizations of small agricultural producers, in Spanish) into participants in the food market in the city of Bogotá. However, these organizations need to enhance their operations; measuring their performance is fundamental for this purpose. The objective of this research was to assess the performance of 60 agroredes in the Central Region of Colombia using the organizational performance index (OPI). For this, a quantitative, transversal and descriptive research was carried out, evaluating agricultural organizations across various dimensions, including administration and finance, associativity and network management, marketing, information and communications technology (ICT), management and logistics, and storage. The organizational performance of the agroredes in the Central Region of Colombia is currently in a consolidation stage. The performance dimensions that have been identified are associativity and network management. However, the most significant challenges are found in ICT management.
Espiritualidade no tratamento quimioterápico: percepções e alterações relatadas
Authors: Fontes De La Longuiniere Agnes Claudine , Dos Santos Maria da Conceição Quirino , Tosoli Gomes Antônio Marcos , Donha Yarid Sérgio
Published: February 2024

Objetivo: descrever as mudanças ocorridas após a inclusão da espiritualidade no tratamento quimioterápico.
Materiais e método: trata-se de estudo qualitativo, realizado com 30 pacientes em tratamento quimioterápico. Os dados foram coletados através de entrevista realizada após a inclusão da prática espiritual na quimioterapia. Realizou-se a análise de conteúdo lexical, por meio do software Iramuteq, pelo método de classificação hierárquica descendente.
Resultados: evidenciou-se que a inclusão da dimensão espiritual pode trazer uma aproximação com a fé, trazer bons pensamentos, melhorar estados e sentimentos, o que ajuda no tratamento. Houvereconhecimento da importância da inclusão dessa dimensão no cuidado em saúde para garantir a integralidade do cuidado.
Conclusões: apesar dos desafios ainda existentes para a abordagem da dimensão espiritual na prática clínica, incluir a espiritualidade no plano terapêutico do paciente pode trazer benefícios para o seu bem-estar e para o enfrentamento da doença.
Economía baja en carbono para el sector agropecuario de la Orinoquia colombiana: una oportunidad para la producción de bioenergía
Authors: Munar Florez David Arturo , Caro Caro Clara Inés , Ramírez Contreras Nidia Elizabeth , García Núñez Jesús Alberto
Published: February 2024

A futuro, la oferta sostenible de alimentos, energía, tierra, y recursos será uno de los mayores retos de la humanidad. El cambio climático afecta al ambiente, impacta negativamente la producción agrícola y aumenta el riesgo de la extinción humana. A esto se agrega el actual modelo de producción, en general ineficiente en el uso del suelo y en la producción en toneladas por hectárea. De continuar este modelo de producción, se aumentarán las emisiones de gases de efecto invernadero a la atmósfera, intensificando los efectos del cambio climático. Tanto los alimentos como la energía deben ser producidos con cero emisiones, mediante la descarbonización del sector agrícola y la aplicación de un modelo de economía baja en carbono. Este artículo hace una compilación de literatura sobre el concepto de economía baja en carbono y analiza su aplicación en la Orinoquia colombiana resaltando la oportunidad de producir bioenergía con bajas emisiones de GEI. La mitigación y adaptación al cambio climático de la Orinoquia es clave para el desarrollo de una economía baja en carbono en la producción agrícola y el uso de la tierra.
Entre locas y bugarrones: género, régimen político y traducción en Reinaldo Arenas
Authors: Bernal Sandoval Nathaly , Arciniegas Hugo Armando
Published: February 2024

En este artículo analizamos las traducciones al inglés de las categorías de las locas y los bugarrones expuestas en dos obras de Reinaldo Arenas: Antes que anochezca (Before Night Falls, trad. Dolores Koch) y El color del verano (The Color of Summer, trad. Andrew Hurley). Para ello, nos valemos de las técnicas de traducción que proponen Lucía Molina y Amparo Hurtado Albir (2002) y los métodos de traducción propuestos por José Luis Martí Ferriol (2006), según la reclasificación de Ericka Vargas Castro (2022). Asimismo, consideramos postulados teóricos de género, como la performatividad y la precariedad, de Judith Butler (2009), o la paradoja de la doxa, de Pierre Bourdieu (1998), puestos en diálogo con la perspectiva sociopolítica de Cuba. Concluimos que predominan las técnicas de traducción literal, de equivalencia acuñada y de creación discursiva. A su vez, esta discusión concerniente a género, régimen político y traducción puede conducir a proponer traducciones consistentes de las denominaciones sexogenéricas en la obra de Arenas.
El Sindbad de Owen en la travesía de Maqroll
Authors: Rodríguez Martínez Daniel
Published: February 2024

A lo largo de la década de 1980, en México tuvo lugar un proceso de revalorización de la labor poética de Gilberto Owen. Tal acontecimiento propició que su poesía fuera leída y discutida desde el ámbito académico e intelectual, al tiempo que se puso de manifiesto su influencia en la obra de escritores contemporáneos. Gracias a su “Rescate de Gilberto Owen” se sabe que Álvaro Mutis no fue ajeno a dicho proceso. Por consiguiente, dado que no se suele hablar de Owen cuando se piensa en el santoral de lecturas del colombiano, se ha profundizado en este vínculo no tan conocido para concluir que existen indicios para pensar que Mutis bien se pudo haber retroalimentado del discurso crítico que emergió en torno a la poesía del mexicano. De esta manera, el retorno inesperado de Maqroll en 1981 se entendería mejor al trasluz del nuevo desembarco de Sindbad el varado en México.
MDMA-assisted dialectical behavioral therapy for borderline personality disorder: A qualitative study of mental health clinicians
Authors: Inouye Ann M. , Wolfgang Aaron S. , Philhower Lianne T.
Published: February 2024

In 2021, the final series of phase 3 clinical trials looking at MDMA-AT for treatment-resistant post-traumatic stress disorder (PTSD) found that 71.2% of 3,4-methylenedioxymethamphetamine (MDMA) full-dose participants no longer met criteria for PTSD. MDMA-assisted therapy is not US Food and Drug Administration (FDA) approved in treating borderline personality disorder (BPD), and while PTSD is quite different from BPD, it is possible that some of the beneficial effects of MDMA-assisted therapy may be applicable in treating BPD. Interviewing two clinicians utilizing dialectical behavioral therapy treatment and two MDMA-assisted therapy clinicians was one way to examine the phenomenology of MDMA-assisted therapy with BPD individuals in a thoughtful manner. An exploratory, qualitative, interview-based study assessed clinicians' perspectives of MDMA-assisted therapy and BPD and increased our understanding of underlying therapeutic mechanisms and processes and the role of pharmacological factors in these treatment modalities, optimizing treatment context, and leading to improved clinical responses and patient recovery. The codes generated unique perspectives of the participants revealing a chronological narrative which included three phases of treatment.
Perceptions and attitudes towards psychedelic-assisted psychotherapy among health professionals, patients, and the public: A systematic review
Authors: Wells Alesha , Fernandes Merciana , Reynolds Lisa
Published: February 2024

Background and aims

Scientific interest in the therapeutic potential of psychedelics has been experiencing significant growth. Understanding the perceptions of psychedelic assisted psychotherapy (PAP) among health professional, patients, and the public is essential to guide future research objectives, trial protocols, and identify any barriers to future implementation.

Methods

A comprehensive search of the databases (Medline, EMBASE, PSYCHinfo, SCOPUS, and Web of Science) was conducted on the 29th of November, 2022. This review included cross-sectional, longitudinal, and quasi-experimental studies published in peer-reviewed journals exploring perceptions of PAP among the three stakeholder groups. Studies were limited to English-language and the years 2012–2022. The protocol and review was conducted according to the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines.

Results

The sample consisted of 29 studies, including n = 17 health professional, n = 6 patients, and n = 6 public. Broadly, knowledge of PAP was low among all three stakeholder groups. There was mixed to positive belief in the therapeutic potential of psychedelics, with male gender, younger age, and personal psychedelic experience/knowledge being key predictors of more favourable views. The majority of findings reported strong endorsement of further research. Consistent themes were identified surrounding concerns about legal status, funding, access, side-effects, and implementation.

Conclusion

The evaluated research indicates a need for further research that will provide clarity about safety and elucidate how PAP may be implemented in public health settings. Further education of health professionals and the public should be a priority.
THE HARMONIOUS BLEND OF CULTURAL ACCULTURATION AND ISLAMIC PRINCIPLES WITHIN THE RICH TAPESTRY OF JAMBI’S RELIGIOUS TRADITIONS
Authors: Zulgafrin Zulgafrin
Published: February 2024

ABSTRACTThis research was carried out to determine Islamic contact with the Malay community in Jambi, through Arab traders and Sufis who entered the area across Jambi City. Apart from that, we also know the process of interaction between Islam and community culture which ultimately gave birth to acculturation to Malay culture and Islamic values. The method used in the research is the historical research method to reveal the history of the entry of Islam into the people of Seberang Jambi City. Research stages include heuristics, criticism, interpretation and historiography. The research results show that the interaction of Islam and Malay society gave birth to acculturation of Islamic culture and values. The acculturation process is through trade relations, marriage, and interactions in adjacent communities. It can be seen in the religious traditions across the city of Jambi, such as in the Malay traditional seloko which contains Islamic values. Apart from that, religious rituals also developed in Jambi Malay society, such as assyuro commemoration, grave pilgrimage, nuak ketan, baby thanksgiving and nisfu Sya'ban, and in artistic traditions including Gambus, zapin dance, Dana Syarah and Hadrah dance.Keywords: Acculturation, Islam and Malay Culture, Religious Culture. ABSTRAKPenelitian ini dilakukan untuk mengetahui kontak Islam dengan masyarakat Melayu di Jambi, melalui para pedagang Arab dan para Sufi yang masuk ke wilayah seberang Kota Jambi. Selain itu kita juga mengetahui proses interaksi antara Islam dan budaya masyarakat yang pada akhirnya melahirkan akulturasi budaya Melayu dan nilai-nilai Islam. Metode yang digunakan dalam penelitian adalah metode penelitian sejarah untuk mengungkap sejarah masuknya Islam ke masyarakat Seberang Kota Jambi. Tahapan penelitian meliputi heuristik, kritik, interpretasi dan historiografi. Hasil penelitian menunjukkan bahwa interaksi Islam dan masyarakat Melayu melahirkan akulturasi budaya dan nilai-nilai Islam. Proses akulturasi tersebut melalui hubungan dagang, perkawinan, dan interaksi dengan masyarakat yang berdekatan. Hal ini terlihat pada tradisi keagamaan yang ada di Kota Jambi, seperti pada seloko adat melayu yang mengandung nilai-nilai keislaman. Selain itu, ritual keagamaan juga berkembang pada masyarakat Melayu Jambi, seperti peringatan assyuro, ziarah kubur, nuak ketan, syukuran bayi dan nisfu Sya'ban, serta dalam tradisi kesenian antara lain Gambus, tari zapin, Dana Syarah, dan tari Hadrah.Kata Kunci: Akulturasi, Islam dan Budaya Malayu, Budaya Beragama
Comprehensibility at a Phonological Level
Authors: Tavakoli Parvaneh , Cooke Sheryl
Published: February 2024

This chapter focuses on the more traditional scope of the comprehensibility/intelligibility construct and takes an analytical approach to examining evidence related to phonemic and prosodic linguistic components affecting comprehensibility of spoken language. An overview of the features that have been identified by previous studies is presented and categorised (e.g. Isaacs & Harding, 2017; Isaacs & Trofimovich, 2012), including those occurring at phoneme level (articulation), word level (segmental units, word stress) and sentence level (intonation, pitch, fluency). The features are then examined from three key perspectives: a) reported impact on comprehensibility b) how the features are reflected in rating scales c) whether the features are L1-dependent.
List of Figures
Authors: Tavakoli Parvaneh , Cooke Sheryl
Published: February 2024

List of Figures
Duncan Garrow and Neil Wilkin, 'The World of Stonehenge'
Authors: Chadburn Amanda
Published: February 2024

Duncan Garrow and Neil Wilkin, The World of StonehengeLondon: British Museum Press, 2022. Hardback, 271 pp. ISBN 978-07141-2349-3-HB. £40.
Peran Kepala Madrasah dalam Pengembangan Kewirausahaan di MTs Nurul Huda Sedati
Authors: Hidayati Nurul
Published: February 2024

Kepala madrasah adalah pemegang kunci untuk keberlangsungan dan keberhasilan di madrasah. Kepala madrasah memiliki peran yang sangat kompleks dalam rangka mewujudkan visi dan misi serta tujuan dari madrasah yang dipimpinnya. Kompetensi Kewirausahaan adalah Kompetensi yang harus dimiliki oleh kepala madrasah, dimana dengan menguasai komptensi tersebut kepala madrasah akan mudah mengembangkan madrasah agar lebih efektif dan efisien. Penelitian ini termasuk kedalam penelitian kualitatif yang mana metode pengumpulan data nya menggunakan wawancara, observasi dan dokumentasi. Pada penelitian ini yang menjadi fokus pembahasan adalah Peran Kepala Madrasah dalam Pengembangan Kewirausahaan di MTs Nurul Huda Sedati. Penelitian ini bertujuan untuk mendeskripsikan tentang kompetensi kewirausahaan sebagai salah satu dari lima kompetensi yang harus dimiliki oleh seorang Kepala Madrasah. Hasil penelitian ini adalah kompetensi kewirausahaan Kepala Madrasah dalam meningkatkan daya saing madrasah meliputi kompetensi yang ada pada diri seorang wirausaha diantaranya mampu membaca peluang, kreatif dan inovatif, bekerja keras, memiliki motivasi, pantang menyerah dan memiliki naluri kewirausahaan.
Peran Manajemen Pendidikan Islam Bagi Pesantren Di Tengah Pandemi Covid-19
Authors: Anshori Isa , Maziyah Elok
Published: February 2024

Abstract: The purpose of this study is to get information about the impact COVID-19 has on the boarding school of Islamic education institutions and identify the role of Islamic education management in the boarding school of Islamic education in dealing with COVID-19. The study uses qualitative methods used to learn information about the effects of COVID-19 on boarding schools. Limited to one respondent is KH. Ilyas Siraj who is the head of the foundation of the boarding school Nurul Islam Karang Cempaka, Bluto, Sumenep, Madura. The interview was conducted by the questions provided by three, where the interview was conducted at his residence. The result of this study is that boarding schools have had very profound effects during the COVID-19 outbreak. Among other things, there are canceled boarding programs, uncontrolled and irreplaceable educational of student character, and finally an aspect of management activity is not well because of the government's policies on the corona strains of education for education.
Keywords:  COVID-19 pandemic, Islamic boarding school, the role of Islamic education management.
Abstrak : Tujuan dari penelitian ini adalah untuk mendapatkan informasi mengenai dampak adanya COVID-19 bagi lembaga pendidikan Islam pesantren serta mengidentifikasi peranan manajemen pendidikan Islam pada lembaga pendidikan Islam pesantren dalam menghadapi pandemic COVID-19. Penelitian ini menggunakan metode kualitatif untuk memahami dampak  COVID-19 bagi pesantren. Subjek  penelitiannya ditentukan secara purposif yaitu KH. Ilyas Siraj  yang merupakan pengasuh sekaigus ketua yayasan dari Pondok Pesantren Nurul Islam Karang Cempaka, Bluto, Sumenep, Madura. Teknik pengumpulan data menngunakan observasi terfokus, wawancara mendalam dan dokumentasi. Data yang dihimpun dianalisis melalui reduksi data, display data dan mengambil kesimpulan. Hasil penelitian menunjukkan,  terdapat beberapa dampak yang teramat sangat dirasakan oleh pesantren ditengah adanya wabah covid-19, yaitu pesantren terpaksa memulangkan para santri, terdapat berbagai macam program kegiatan pesantren yang dibatalkan, penanaman pendidikan karakter santri yang tidak dapat terkontrol dan tidak dapat tergantikan dengan system online, dan yang terakhir aspek kegiatan manajemen tidak berjalan baik karena kebijakan pemerintah mengenai wabah corona bagi pendidikan dirasa terlalu mendadakan.
Kata kunci : pandemi COVID-19, Pesantren, Peran Manajemen Pendidikan
NEGOTIATING RELIGIOUS IDENTITIES AND MODERNITY IN MALUKU: A Socio-Historical Perspective
Authors: Gaspersz Steve Gerardo Christoffel , Souisa Nancy Novitra
Published: February 2024

This research article was based on a literature review using the lens of a socio-historical perspective on the dynamic relationship between Islam and Christianity in Maluku throughout the social history of the Maluku archipelago. The research question “How did the metamorphosis of religious identities (Islam and Christianity) take place through the history and contemporary social reality in Ambon?” becomes a reference to trace the historical trajectory of relations between the two religions in Maluku. The religious conflict that occurred from 1999-2005 still leaves social residues that must be carefully considered for the future of these two religions in Maluku and Indonesia. A hermeneutic analysis of social history was used to map the sociological variables that determine the existence and interaction of Islam and Christianity in Maluku, which in turn also determine interfaith relations at large in the context of Indonesia’s pluralistic society. A multidisciplinary approach was used to synthesize various documents and analyses of some experts, especially Pierre Bourdieu’s sociological analytical framework. The result of this research is the construction of historical understanding that must be understood in managing religious pluralism, especially in the relations between Islam and Christianity in Maluku and Indonesia.
The Ethical-Dialectic Relationship of Islam and Indonesia: Reviewing Ahmad Syafii Maarif’s Thought
Authors: Arifin Syamsul , Abdeljelil Moncef Ben , Mu’ammar Muhammad Arfan , Yusuf Muhammad
Published: February 2024

Ahmad Syafii Maarif—affectionately known as Buya Syafii—is one of the Indonesian leading Muslim intellectuals and is a well-known national figure. This article examines Maarif’s Islamic thought and his dialectical-ethical link between Islam, national identity, and humanity. Using an in-depth textual analysis of the primary sources and supported by selected secondary sources, this study attempts to reveal Maarif’s intellectual legacy. This study concludes that Maarif was a Muslim intellectual who developed the model of a religious and democratic state. He bases his main argument that Islam does not need to be placed in a ‘binary opposition’ to the political reality and the national consensus, i.e., Pancasila as the last stated entity evidently accommodates the teachings of the Qur’an. He insisted that the ethical principles of Pancasila, which are in line with Islam, should be absorbed into public life in order to bring forth the right nation and the right state. To him, Islam in Indonesia must thus manifest itself as an ‘ethical entity’ to become the basis for modern Indonesia. He also called Muslims in Indonesia and elsewhere to comprehend the universal moral message of the Qur’an which has a versatile and immutable reach.
Effect of the bone marrow mesenchymal stromal cells cytokine-producing activity on mobilization of hematopoietic stem cells
Authors: Poponina E. A. , Pestrikova A. O. , Nazarova E. L. , Isaeva N. V. , Fokina E. S. , Endakova A. I. , Minaeva N. V.
Published: February 2024

Hematopoietic stem cell transplantation is used to treat hemoblastoses and some other diseases. Depending on the diagnosis, autologous cells of the patient or allogeneic cells obtained from a healthy related or unrelated donor are used. A sufficient count of harvested hematopoietic progenitor cells is necessary for successful transplantation. Currently, stimulation of their egress from the bone marrow into the peripheral blood by a granulocyte colony-stimulating factor, followed by collection by leukapheresis, is widely used for their preparation. Hematopoietic stem cells leave the bone marrow niche formed by the stromal microenvironment when their holding bonds are interrupted. Mesenchymal stromal cells regulate the release of hematopoietic precursors by producing various cytokines and other biologically active substances. Therefore, the study of the functional properties of bone marrow mesenchymal cells can help in solving the problem of “poor” mobilizations that occur in patients with multiple myeloma.

The aim of the study was to estimate the effectiveness of mobilization of hematopoietic stem cells depending on the cytokine-producing ability of mesenchymal stromal cells in the bone marrow of donors and patients with multiple myeloma.

The yields of hematopoietic progenitors were studied in 10 donors (median age 27 years) and 18 patients with multiple myeloma (median age 57 years). In donors, the release of hematopoietic stem cells into the peripheral blood was stimulated by subcutaneous administration of G-CSF at a dose of 10 μg/kg/day. Patients with multiple myeloma received vinorelbine at a dose of 35 mg/m2 of body surface, followed by administration of G-CSF (10 μg/kg/day subcutaneously). A culture of mesenchymal stromal cells was obtained from bone marrow taken prior to mobilization and the content of interleukins IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, TNF-α and IFN-γ in supernatants was studied by enzyme-linked immunosorbent assay using kits of reagents produced by Vector-Best (Novosibirsk).

Patients with multiple myeloma were characterized by high secretion of the pro-inflammatory cytokine IL-2 (4.70 pg/ml vs 3.55 pg/ml in healthy individuals, p=0.003) and low IFN-γ (0.41 pg/ml vs 2.14 pg/ml in healthy, p<0.001), but no relationship was found between these cytokines and the hematopoietic stem cells yield. The present study showed that in patients with ineffective harvesting of hematopoietic precursors, secretion of IL-8 by stromal cells was low (308.08 pg/ml vs 561.29 pg/ml in healthy individuals, p=0.04).

The obtained results are consistent with the literature data on the important role of IL-8 in the mobilization of hematopoietic stem cells, which allows to consider IL-8 as an informative marker for predicting the insufficient yields of hematopoietic precursors.
A new approach to immunosuppressive therapy in patients with glomerulonephritis with nephrotic syndrome
Authors: Kudryashov S. I. , Stenina M. A. , Karzakova L. M. , Lutkova T. S.
Published: February 2024

Glomerulonephritis (GN) is a group of immuno-inflammatory kidney diseases with predominant glomerular lesions that are difficult to treat. The greatest problems are caused by the treatment of GN with nephrotic syndrome, which often has a recurrent course. The aim of the research was to study the effectiveness of recombinant interleukin-2 (rIL-2) therapy in the GN patients with nephrotic syndrome. 62 patients with a nephrotic form of primary GN with frequent relapses admitted to the Nephrology Department have been recruited into the study. The age of patients was from 18 to 65 years. The patients underwent standard examinations, as well as immunological studies, before administration of the anti-relapse treatment, and 12 months after the treatment was started. Immunological testing included immunophenotyping of lymphocytes with counting of T and B lymphocytes, immunoregulatory and activated subpopulations of T lymphocytes, determination of urinary immunoglobulins (IgM, IgG, IgA) by immunoturbidimetric assays, proinflammatory cytokines – IL-1β, IL-8, IL-17A and anti-inflammatory cytokine IL-10 by ELISA tests. As a result of studies, the examined patients showed an increased contents of T helper cells, activated T lymphocytes (CD8+HLA-DR+CD45+, CD3+CD8brightCD38+) along with decreased numbers of Treg cells and an increased contents of proinflammatory cytokines IL-1β, IL-8, IL-17A and immunoglobulins of all three classes in urinary samples.

The cohort of patients with GN selected for the study was divided in two groups (the main group and the comparison group). In addition to nephroprotective and steroid therapy, the treatment regimen of patients included rIL-2 in the main group, or cyclophosphamide in the comparison group. Regardless of the method used, the levels of protein, IgG and IL-17A in the urine proved to be decreased relative to the initial values; the contents of B cells and HLA-DR+ cytotoxic T lymphocytes in peripheral blood were found to be decreased. The revealed changes were more pronounced in the main group of patients. By 12 months after starting the treatment, the mentioned indexes began to differ significantly in the main group from those in the comparison group. Serum creatinine levels, numbers of T helper cells and Treg cells, IL-1β levels in urine did not undergo significant changes in the comparison group, whereas a decrease in serum creatinine and urinary IL-1β was registered in the main group of patients, along with decreased number of T helpers and increased numbers of Treg cells. In the main group of patients treated with rIL-2, the average number of relapses per year decreased by 4 times, showing only a 1.2-fold decrease in the comparison group. Hence, the low-dose therapy with rIL-2 may be considered an effective and safe alternative to conventional immunosuppressive therapy and a new option of the targeted treatment of glomerulonephritis with frequent recurrence of nephrotic syndrome.
Assessing the impact of a rare synonymous variant in the KNG1 gene on the development of hereditary angioedema
Authors: Pechnikova N. A. , Ostankova Yu. V. , Saitgalina M. A. , Bebyakov A. M. , Totolian A. A.
Published: February 2024

The main cause of edema in hereditary angioedema (HAE) is due to elevated bradykinin levels, caused either by C1-INH deficiency/change in functional activity and caused by mutations in the SERPING1 gene or by mutations in the F12, PLG, ANGPT1, KNG1, MYOF and HS3ST6 genes with a normal level and functionality of the C1-esterase inhibitor. The aim of the work was in silico prognostic analysis of the rare synonymous variant NC_000003.12:g.186725098T>C in the KNG1 gene and its impact on the development of HAE symptoms. The material was a whole blood sample obtained from a woman with clinical manifestations of hereditary angioedema without a decrease in the levels and function of the C1 inhibitor. The research methods included whole exome sequencing, bioinformatic analysis of the KNG1 gene mutation using a number of databases and web resources. Results. When processing full-exome sequencing data, we detected a synonymous variant in the KNG1 gene (exon 4, isoform 1): NC_000003.12:g.186725098T>C. The patient is a heterozygous carrier of the variant, with a frequency of 0.000004 (1:264690). Presumably, the identified variant can lead to the development of sporadic edema through several pathways that are associated with the formation of bradykinin or its analogues. Therefore, (1) the mutant high-molecular-weight kininogen is more easily activated by kallikrein and becomes a source of bradykinin formation through the kallikrein-kinin system; (2) the mechanism of bradykinin formation undergoes significant changes and results in the formation of functionally active but aberrant bradykinin, which alters its inactivation by enzymes with a consequent increase in its half-life, (3) the changes in positions 380-389 bring about modifications in Lys-bradykinin reproduction such that in subsequent steps it is “easily” cleaved to bradykinin by arginine aminopeptidase. The results of our study therefore indicate a possible role of the identified variant in the KNG1 gene in the development of HAE.