Abstract 3218: Lifestyle intervention of food and exercise for lymphoma survivors (LIFE-L): a pilot intervention protocol for adults
Authors: Rossi Paola , Pissinis Moira , Lopez-Pentecost Melissa , Freylersythe Sarah , An Hong Su , Rolle Lashae , Moskowitz Craig , Crane Tracy 
Published: April 2023

Background: Lymphomas are among the top seven most frequent cancers in men and women in the United States. In 2022, more than 21,000 deaths related to this neoplasm are expected. The use of common treatment modalities (e.g., chemotherapy, radiation, stem cell transplant) may lead to negative physical and psychosocial symptoms. Furthermore, these adverse effects decrease treatment tolerance and adherence. Little is known about the potential of lifestyle factors (nutrition and physical activity) to mitigate these adverse events in lymphoma patients. To fill this gap, we propose a pilot feasibility study to assess the impact of healthy diet and exercise intervention on relative dose intensity (RDI), an integrated measure of chemotherapy dose delays and reductions; patient-reported outcomes, (e.g., quality of life (QoL), fatigue, and cognition);immune and metabolic markers; and body composition.

Methods: 60 newly diagnosed lymphoma patients will be recruited in this two-arm stratified (by treatment type) randomized waitlist controlled pilot study. Eligibility criteria include adults fluent in English or Spanish, presenting with any type of lymphoma at any stage, receiving one of the following three chemotherapy regimens: R-CHOP, BR, B±ABVD. Participants must have clearance from their oncologist to participate. Participants must have access to the internet through an electronic device. They are randomized to either the intervention arm, that consists of telephone- or video call-delivered health coaching to achieve a Mediterranean diet and 150 minutes per week of moderate or vigorous exercise, or a waitlist control (n=15) arm which will receive the study materials and two telephone-based coaching sessions after study completion. Interventions will take place during active treatment. Data will be collected prior to randomization, the third and sixth cycle of chemotherapy, and four weeks post-treatment at standard of care visits through self-reported questionnaires, anthropometric measures, physical assessments, ActiGraph watches, blood samples, CT scans (if available), and clinical information from electronic medical records (EMR).

Discussion: Results from this pilot will provide valuable information about the feasibility, acceptability, and preliminary efficacy of a lifestyle intervention in lymphoma patients undergoing active treatment. Lessons learned from this study seek to fill the gap in supportive oncology care programs among lymphoma patients to improve treatment outcomes, such as RDI, and patient reported outcomes, and overall QoL.

Citation Format: Paola Rossi, Moira Pissinis, Melissa Lopez-Pentecost, Sarah Freylersythe, Hong Su An, Lashae Rolle, Craig Moskowitz, Tracy Crane. Lifestyle intervention of food and exercise for lymphoma survivors (LIFE-L): a pilot intervention protocol for adults [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 3218.