bluuebunny/crossref_metadata_2025 huggingface dataset:
Istri Bergaji: Analisis Peran Wanita Bekerja Dalam Meningkatkan Ekonomi Keluarga
Authors: Dessy Asnita Fika Andriana, Agustinar &
Published: July 2021

The Cases in this paper include what are the causes of wives having to work outside as housewives? And what is the position of wives in running as housewives and their position as workers in order to improve the family economy? The purpose of writing this paper is to find out the causes of wives working outside other than as housewives and also as working mothers. This writing uses a qualitative descriptive method. The Information collection method used in this paper is observation, interviews, and data analysis using two data, namely primary and secondary data. The result of this paper indicates that some of the causes of wives having to work outside, among others, are the desire to increase family income, the desire to help husband because the wife’s income tends to below, and apply the knowledge gained during education in the world of work. The role of the wife in this paper looks very influential in improving the family economy. Because a working wife can fill meaningful sectors in the family. These include education, health, economic and social zones. In addition, with the work of the wife, the position of the wife automatically becomes double, namely as a housewife and a working mother.
Revisão Sistemática Sobre Os Impactos Das Ferramentas De Mentoring Nas Organizações
Authors: Loureiro Adeylson Felix , Scatolin Henrique Guilherme
Published: July 2021

Diante do contexto de mudanças na dinâmica organizacional, é imprescindível explorar ferramentas de capacitação que integram resultados mais competitivos e significativos. Portanto, essa pesquisa tem por objetivo realizar um levantamento sistemático acerca da aplicação do mentoring no ambiente organizacional, avaliando as ferramentas utilizadas nos últimos cinco anos. Para isso utilizou-se as bases de dados Google Scholar e SciELO. Essa busca gerou 27 ocorrências, das quais apenas 22 são utilizadas para revisão através da base Google Scholar. A análise desse estudo é decorrente dos artigos encontrados através dos critérios de inclusão na base Google Scholar, onde apenas 10 foram considerados aptos. Esse levantamento pôde evidenciar que o mentoring é explorado somente por sua finalidade teórico-prática, mas não como uma ferramenta individual de aplicação.
Inibição De Elastase Por Extratos De Cordia Superba: Um Estudo In Vitro
Authors: Barbosa Karen Eduarda , Santos Jorge Alexandre Nogueira
Published: July 2021

As proteases desempenham papéis fisiológicos em seres humanos e quando tem sua atividade desregulada podem gerar diversos problemas e enfermidades. A atividade proteolítica aumentada da elastase, uma serino protease produzida pelo pâncreas e neutrófilos, está relacionada com algumas com envelhecimento precoce da pele e algumas enfermidades como enfisema pulmonar e fibrose cística. Tendo em vista que plantas produzem diferentes classes de compostos bioativos, o presente estudo teve como objetivo avaliar o efeito inibitório de extratos brutos aquosos e etanólicos da planta Cordia Superba sobre a atividade enzimática da elastase. Ambos os extratos apresentaram relevante inibição sobre a atividade proteolítica da elastase. O extrato aquoso apresentou porcentagem de inibição máxima de 99% na concentração de 440 µg/ml e IC50 de 77,3 ± 16,4 µg/ml.O extrato etanólico inibiu com uma porcentagem máxima de 73% na concentração de 308 µg/ml, com IC50 de 154,1 ± 26,5 µg/ml. Em conclusão, os resultados sugerem que os extratos brutos de Cordia Superba podem ser uma boa fonte para prospecção de inibidores da elastase.
Diversidad y dinámica poblacional de Scolytinae (Coleoptera: Curculionidae) en plantaciones de palto y bosque natural circundante en el NW de Argentina
Authors:   Instituto de Entomología, Área de Zoología, Fundación Miguel Lillo, Córdoba Silvia Patricia , Mendoza Eduardo Agustín ,   Instituto de Ecología, Comportamiento y Conservación, Área de Biología Integrativa, Atkinson Thomas Harris ,   University of Texas, Insect Collection, Manzo María Verónica ,   Instituto de Biodiversidad Neotropical (UNT – CONICET)
Published: July 2021

Scolytinae es un grupo de escarabajos descortezadores y ambrosiales ampliamente distribuidos capases de usar una extensa gama de huéspedes. El estudio de su diversidad permite estimar la riqueza y abundancia de las especies así como su dinámica poblacional. Algunas especies afectan cultivos de importancia comercial, causando por ejemplo, una enfermedad vascular letal en árboles de la familia Lauraceae incluyendo el palto o aguacate. El objetivo de este trabajo fue dar a conocer la diversidad de especies y su dinámica poblacional en la principal zona productora de palta de Argentina. Los adultos se capturaron usando trampas de etanol, desde noviembre de 2016 hasta febrero de 2018 y a través de colecta manual. Se midieron las variables climáticas y se calcularon los índices de diversidad, índice de similitud y la importancia relativa de las especies. Fueron recolectados 39.309 especímenes pertenecientes a ocho tribus. Xyleborini fue la tribu mejor representada. Cryptocarenus heveae (Hagedorn, 1912), Hypothenemus seriatus (Eichhoff, 1872), Monarthrum bicolor (Ferrari, 1867), Orthotomicus laricis (Fabricius, 1792) y Xyleborinus sentosus (Eichhoff, 1868) fueron nuevos registros para la provincia de Tucumán. Theoborus ricini (Eggers, 1932) fue nueva cita para la Argentina. Xylosandrus crassiusculus (Motschulsky, 1866), Xyleborus bispinatus Eichhoff, 1868, Xyleborinus saxeseni (Ratzeburg, 1837) y T. ricini fueron registrados por primera vez para el cultivo de palto en Argentina. El aumento de la temperatura y las precipitaciones fueron los factores que mejor explicaron las fluctuaciones poblacionales. La fauna de Scolytinae asociada al cultivo de palto y bosque natural circundante fue similar, con mayor diferencia de X. crassiusculus en el bosque natural. En general las especies registradas en este trabajo estuvieron presentes durante todo el año, aumentando su abundancia por factores tales como el incremento de la temperatura y las precipitaciones; sin embargo es necesario considerar las características del hábitat para explicar su dinámica poblacional.
Solidaridad y humor, caricaturas y memes en torno a un terremoto.
Authors: Fernández Poncela Anna María
Published: July 2021

Este trabajo es un acercamiento al sismo de magnitud 7.1 en México, el 19 de septiembre del año 2017. En concreto una revisión de expresiones culturales y humorísticas que aparecen en los medios de comunicación y las redes digitales en torno al temblor: las caricaturas y los memes. Como resultado principal se señala el destacado papel de la solidaridad ante la tragedia y también la crítica política. Las emociones de amor y miedo, y de enojo, se mostraron junto a la empatía, como parte de transitar la tensión existente, de vincularse y consolarse, aliviar el estrés y mostrar comprensión y solidaridad.
Significación sobre la diferencia entre violencia y conflicto escolar : un estudio de caso sobre sujetos que han sufrido o generado violencia.
Authors: Jaramillo Valencia Bairon , Pineda Taborda Claudia Maria
Published: July 2021

Este artículo tiene como propósito establecer una mirada diferente sobre la importancia de entender quiénes son los sujetos que participan en el acto escolar, en el conflicto y en la violencia escolar; y de igual forma, develar que los fenómenos ‘violencia’ y ‘conflicto escolar’ son diferentes a partir de las significaciones que construyen ambas nociones desde una perspectiva hermenéutica. A su vez, la investigación base para la escritura de este texto se ejecutó bajo un paradigma cualitativo con enfoque hermenéutico y tipo de investigación estudio de caso, a través de técnicas de recogida como: encuestas, entrevistas semiestructuradas y grupos focales. Finalmente, este estudio se llevó a cabo en la Escuela San José de los Hermanos Terciarios Capuchinos sede Copacabana-Antioquia, con la participación de la Universidad Católica Luis Amigó-Medellín. Sobre los hallazgos más significativos, se resaltan la no claridad percibida por los participantes hacia lo entendido por violencia y conflicto, al igual que la confusión sobre forma, contenido y características de dichos actos. Finalmente, a manera de conclusión se determina que no se halla una forma clara y definida de la expresión ‘violencia’, refiriendo el vocablo amplio o restringido como el más interesante.
Significados emocionales sobre el abuelazgo temprano e inesperado.
Authors: Marín Rengifo Alba Lucía
Published: July 2021

El presente artículo tiene como objeto analizar el significado emocional del abuelazgo temprano e inesperado a partir de la base de datos de una investigación precedente, realizada en cuatro zonas del oriente del departamento de Caldas- Colombia, en el año 2014, en la cual participaron abuelas y abuelos, agentes educativos, niñas y niños, a través de grupos focales, entrevistas a profundidad y talleres. Desde el lente del abuelazgo y las emociones se realizó un proceso de selección, decantación y sistematización de la información registrada que fue sometida a combinaciones teóricas, asociaciones y transferencias conceptuales y metodológicas con el fin de construir un acercamiento hermenéutico en torno al significado emocional de este particular proceso de vida personal y familiar. Un mapa vital, complejo que hace visible la ambigüedad y ambivalencia emocional alrededor de la pertenencia familiar, el peso del linaje parental y la proyección de la vida.
tercer congreso médico nacional en cartagena (1918): representación en la prensa comercial local.
Authors: Sierra Merlano Rita M. , Simancas Mendoza Estella
Published: July 2021

El Tercer Congreso Médico Nacional se realizó en Cartagena en 1918. El presente trabajo tiene por objetivo investigar cómo la prensa comercial de la ciudad registró los discursos, actores y ponencias de ese evento. Se hizo una búsqueda de las referenciasal evento en la prensa local cartagenera y en las publicaciones nacionales del programa y las ponencias. El problema es abordado desde la sociología histórica y la historia social de las ideas. Se muestra como la prensa fue un medio expedito del saber médico quevisualiza y afirma su autoridad científica e ingerencia política en materia de higiene y salud pública. Rev.cienc.biomed. 2011; 2(1): 163–172
Meningioma falcotentorial, una localización inusual : presentación de un caso en paciente masculino y revisión de la literatura.
Authors: Rivero Monterrosa Saúl Andrés , Maury Ayala Andrés , Segovia Fuentes Javier , Tuñón Pitalúa Martha
Published: July 2021

Introducción: los meningiomas representan los tumores cerebrales primarios más frecuentes. Hasta el 90% de los casos son tumores de bajo grado. Son más frecuentes en mujeres entre la cuarta y sexta década de la vida, con una relación hombre/mujer de 3:1. Caso clínico: se presenta el caso de un hombre en la sexta década a quien por medio de neuroimágenes se le demuestra una gran masa circunscrita de localización falcotentorial, con criterios radiográficos e histopatológicos de meningioma, caso que resalta por la presentación clínica tan elocuente y lo infrecuente de esta localización. Conclusiones: los meningiomas son tumores más frecuentes en mujeres, se encuentran comúnmente en la convexidad cerebral de localización supratentorial; las localizaciones variantes implican un reto diagnóstico siendo la localización falcotentorial extremadamente rara, con pocos informes de los hallazgos de imágenes en esta localización.
Preliminares
Authors: Editorial Comite
Published: July 2021

Preliminares
Metsá Kené : los diseños y la identidad del pueblo Shipibo-Konibo.
Authors: Favaron Pedro , Bensho Chonon
Published: July 2021

La nación shipibo-konibo es un pueblo indígena de la Amazonía peruana. Pertenece a la familia lingüística pano y se asienta, principalmente, en las orillas del río Ucayali y del río Psiqui. También se pueden encontrar algunas comunidades shipibas en otras ciudades del Perú, como Tingo María, Iquitos o Lima. Una de sus características más saltantes es la belleza de sus diseños geométricos, que reciben el nombre de kené. Desde abril del 2008, y gracias al trabajo conjunto de antropólogos, artistas shipibos y autoridades sensibles a la belleza del arte indígena, el kené fue declarado Patrimonio cultural de la nación por el ahora desaparecido Instituto Nacional de Cultura del Perú. En el presente texto, se dará cuenta sobre los diseños kené desde la propia perspectiva indígena, proponiendo la posibilidad de una escritura académica intercultural que permita a los conocimientos ancestrales expresarse desde su temperamento poético y narrativo.
La narrativa quechua contemporánea en Perú como sistema : el inmenso caleidoscopio de la literatura latinoamericana.
Authors: Manino Marcia Muriel
Published: July 2021

El libro en cuestión da cuenta, crítica y detalladamente, de una cartografía de escrituras quechuas que inician en 1970 y que, por años, fueron invisibilizadas en el sistema literario latinoamericano. El estudioso moche emprende la tarea que Antonio Cornejo Polar (1989), en “Apéndice: La literatura peruana como totalidad contradictoria” propone como ineludible: pensar a la multiplicidad del escenario escriturario en Latinoamérica como una totalidad contradictoria. Para entender las producciones literarias que representan al plano social y cultural de nuestro continente se debe atender a los dinamismos que subyacen en el sistema. Estamos ante un movimiento y el libro de Espino Relucé es un fuerte e innovador aporte para ello.
EFEITOS DA PRÁTICA SISTEMÁTICA DE FUTEBOL NO DESENVOLVIMENTO DE HABILIDADES MOTORAS FUNDAMENTAIS
Authors: Xavier Breno Henrique da Silva , Uriat Caique , Gomes Thábata Viviane Brandão , Marinho Nádia Fernanda Schmitt
Published: July 2021

Estudos de corte transversal apontam que a prática de esporte de forma sistematizada auxilia no desenvolvimento das habilidades motoras fundamentais (HMF). Neste tipo de delineamento não se pode afirmar que a prática do esporte auxiliou as crianças no seu desenvolvimento motor, ou se as crianças procuraram a prática de um esporte por terem desenvolvimento motor alto. O objetivo deste estudo foi verificar os efeitos da prática sistemática de futebol no desenvolvimento de habilidades motoras fundamentais a partir de um delineamento longitudinal. Participaram do estudo 10 meninos, sendo 04 iniciantes na prática sistematizada de futebol (GPF= 6,65±0,39 anos) e 06 sedentários (GC=6,42±0,44). O GPF realizava além das aulas de Educação Física, prática orientada de futebol duas vezes por semana, uma hora/dia. O GC realizava apenas aulas de educação física escolar. Utilizou-se como medidas o escore padrão locomotor e de controle de objetos do Test of Gross Motor Development (TGMD-2). Os grupos realizaram o primeiro teste no início do ano e, após 6 meses, realizaram o segundo teste. O teste U de Mann Whitney  não apontou diferença significante entre os grupos antes ou após intervenção em nenhuma das variáveis (p>0,05). O teste de Wilcoxon, com correção de Bonferroni (p<0,025), não apontou diferença significante entre pré e pós-teste para nenhum dos grupos (p>0,05). Estes resultados indicam que as habilidades do futebol (especializadas), podem não beneficiar o desenvolvimento de HMF, confirmando a ideia de hierarquia do desenvolvimento. Estudos futuros podem analisar a qualidade das aulas oferecidas,  diferentes tempos de intervenção e uma amostra maior.
Selected Buildings in Transylvania: About Ybl Miklós' Designs
Authors: Popescu Mara
Published: July 2021

Ybl Miklós is a leading figure of nineteenth-century architecture, one of the prestigious Hungarian architects who won the Franz Jozef Knights' Cross and the Knight's Cross Order of Leopold medals, a member of Budapest's Board of Public Works and the Association of Architects and Engineers. His works represented highly complex national and European heritage values and were a reference point for nineteenth century Hungarian architecture. In 2014, when UNESCO celebrated the bicentennial of the birth of Ybl Miklós, it marked both his personality and the architect's vision. In his honour, the Faculty of Architecture and Civil Engineering of the Szent István University in Budapest bears his name.Some of his works in Transylvania and the connections he had with Transylvanian nobles are lesser known. This article highlights another aspect of his work.
Energy Balance of a Low Energy House with Building Structures with Active Heat Transfer Control
Authors: Kalús Daniel , Straková Zuzana , Kubica Matej
Published: July 2021

A qualitatively new dimension has been introduced to the issue of building structures for energy-efficient buildings by the system of Active Thermal Insulation (ATI), which is already applied in the construction of such buildings. ATI are embedded pipe systems in the envelope structures of buildings, into which we supply a heat-carrying medium with adjusted temperature, so this constitutes a combined building-energy system. This introduces the concept of an internal energy source understood as an energy system integrated into the zone between the static part and the thermal insulation part of the building structure envelope. Under certain conditions, the ATI can serve as a heat recuperator or as an energy collector for a heat pump application. ATI consists of pipe systems embedded in building structures, in which the medium circulates heated by energy from any heat source. The function of the system is to reduce or eliminate heat losses through non-transparent structures in the winter and at the same time to reduce or eliminate heat gains in the summer. It is especially recommended to apply heat sources using renewable energy sources due to the required low temperatures of the heating medium and thus shorten the heating period in the building. Also recommended is to apply ATI for the use of waste heat. Buildings with a given system show low energy consumption and therefore meet the requirements of Directive no. 2018/844/EU, according to which, from 01.01.2021, all new buildings for housing and civic amenities should have energy needs close to zero.
THE HYBRID SUBISCHIAL SOCKET FOR PERSONS WITH TRANSFEMORAL AMPUTATION: GAIT PARAMETERS AND CLINICAL ASSESSMENT OF A CASE SERIES
Authors: Pellegrini Roberto , Denza Gabriele , Brunelli Stefano , Zenardi Daniele , Imperio Matteo , Vannozzi Giuseppe , Traballesi Marco
Published: July 2021

BACKGROUND: The subischial socket interface design is a promising new shape of socket for persons with transfemoral amputation. Typically, the proximal trim line is located distal to the ischial tuberosity, improving comfort in prosthetic users without interfering with gait parameters compared to Ischial Containment Socket (ICS). No studies have investigated the performances of a subischial sockets with suction suspension system. A new subischial socket (Hybrid Subischial Socket - HySS) combined with a hypobaric passive suspension system has been recently developed.

OBJECTIVE: To assess the effects of HySS in terms of comfort, hip range-of-motion and gait parameters.

METHODOLOGY: Three persons with transfemoral amputation were tested first using their usual ICS and then after one month of continuous use of HySS.

FINDINGS: The following parameters improved in all participants using HySS: 1) hip range-of-motion, 2) walking speed and distance, 3) Timed-Up-and-Go-Test time, 4) stride length, 5) double support duration, 6) peak value of hip extension during stance, 7) satisfaction with the prosthesis.

CONCLUSION: These findings suggest that the use of HySS could allow improvements for prosthetic use.

Layman’s Abstract

This case series describes the effects of a subischial socket combined with a hypobaric suction suspension system for persons with transfemoral amputation. This socket has the proximal trim line located distally to the ischial tuberosity and it does not interact with the pelvis. The results have shown that this socket may improve the overall prosthetic comfort, hip range of motion and some gait parameters compared to the conventional ischial containment socket.

Article PDF Link: https://jps.library.utoronto.ca/index.php/cpoj/article/view/36252/28095

How To Cite: Pellegrini R, Denza G, Brunelli S, Zenardi D, Imperio M, Vannozzi G, Traballesi M. The hybrid subischial socket for persons with transfemoral amputation: gait parameters and clinical assessment of a case series. Canadian Prosthetics & Orthotics Journal. 2021;Volume 4, Issue 1, No.9. https://doi.org/10.33137/cpoj.v4i1.36252

Corresponding Author: Stefano Brunelli, MDFondazione Santa Lucia, Scientific Institute for Research, Hospitalization and Health Care, Rome, Italy.E-Mail: s.brunelli@hsantalucia.itORCID ID: https://orcid.org/0000-0002-5986-1564
A Review of Periodontal Ligament-Derived Mesenchymal Stem Cells Being Used to Regenerate the Periodontal Ligament and Periodontium
Authors: Anderson Natalie J. , Gallicchio Vincent S.
Published: July 2021

Periodontal disease is an inflammatory disease of the tissues making up the periodontium that consists of alveolar bone resorption, recession of the gingiva, as well as damage to the periodontal ligament and cementum caused by accumulation of bacteria in the oral cavity. The method of treatment is dependent upon the depth of pocket formation and stage of disease advancement. When pockets are at a depth between 4 and 5 mm, nonsurgical treatments such as scaling, root planning, and antibiotics are used to treat. Surgical methods are used, however, when pockets are deeper than 5 mm. Both nonsurgical and surgical treatments currently used have limited capabilities to regenerate parts of the periodontium. The discovery of periodontal ligament-derived mesenchymal stem cells and their ability to generate cementoblasts, osteoblasts, adipocytes, chondroblasts, and fibroblasts in vitro that all contribute to the formation of the periodontium. This paper discusses the aims of current and future research on periodontal ligament stem cells and their potential to regenerate the periodontal ligament, as well as the entire periodontium.
Volumetric Modulated Arc Therapy Craniospinal Re-Irradiation of Adulthood Medulloblastoma Leptomeningeal Disease
Authors: Petrova Kremena , Marinova Lena , Yankov Zdravko , Nikolaeva Dimka
Published: July 2021

For the first time in the English medical literature we present two adulthood clinical cases with medulloblastoma leptomeningeal disease (LMD) in which we have performed second craniospinal irradiation (re-CSI) using bias volumetric-modulated arc therapy (VMAT) technique. In this article we present bias volumetric-modulated arc therapy (VMAT) technique for repeated CSI (re-CSI) in two patients with adulthood medulloblastoma leptomeningeal disease (LMD). In both clinical cases (case1/case2) with adulthood medulloblastoma LMD, re-CSI has been performed using the bias VMAT technique in the area of the spinal cord up to total dose (TD) - 24 Gy/32 Gy; cauda equina up to TD- 28 Gy/38 Gy; in the cerebellum up to TD- 24 Gy/28 Gy; both cerebral hemispheres up to TD- 26 Gy/32 Gy and the cerebral ventricles up to TD-30 Gy/38 Gy with daily dose (DD)-1.8 Gy (17/21fractions). We describe in detail the stages of dosimetry planning of this radiotherapy technique, presenting its advantages and disadvantages, the observed early radiation toxicity and the possible treatment outcome. Volumetric-modulated radiotherapy with bias dose VMAT technique in adulthood medulloblastoma patients achieves improved dose homogeneity at the junction of the fields, increased compliance with the target volume and minimized dose to the organs at risk (OARs).
PPARS - Peroxisome Proliferator Activated Receptor Activators and Fibrates Actions
Authors: Fernandes Sidney Carvalho , Saldanha Anita L. R. , Margeotto Ana Paula Pantoja , Gasparoto André Luiz Valera , Martinez Tania Leme da Rocha
Published: July 2021

Peroxisome Proliferator Activated Receptor sits part of the family of nuclear receptors, which has about 50 known receptors, including thyroid hormone receptors, which have the function of regulating metabolism and metabolizing and eliminating substances. These receptors, to act, must be activated by ligands, form a heterodmer with the retinoic acid receptor, recruit activating cofactors, release inhibitory cofactors to which they are bound, and then act on the responsive element of target gene. Three species of peroxisome proliferator activated receptor are known: PPARa, PPARγ and PPARβ (also known as PPARd or β/d). The prototypes of PPARa activators are the derivatives of fibricacid, of which the first representative was clofibrate, used as a lipid-lowering factor in the 1960s and 1970s. Although there may be a small variation among the various fibrates regarding the mechanism of action, these drugs are basically PPARa activators. In the action of fibrates, there is a reduction of triglycerides, with a decrease in the synthesis of VLDL, increase of HDL particles and transformation of small and dense LDL into larger, less dense LDL and with lower atherogenic potential. Fibrates are second-choice substances, and statins are the first for the treatment of hypertriglyceridemia. Fibrates are efficient for the treatment of patients with low HDL-C, decrease macro and microvascular disease of diabetic patients. The recommendation is do not associate gemfibrozil with statins. Other fibrates may be associated, and preference should be given to the association of statins that are not metabolized by CYP3A4: rosvastatin, pravastatin and fluvastatin.
The Algorithms Cruz Rodriguez (CR) are Proposing A Novel Vaccine RNA-Peptide against Breast, Ovarian, and Lung Cancers Disease: Exosomes as Carrier in Cancer Progression and Metastasis
Authors: L Cruz-Rodriguez , N Dilsiz , R Barea , P Ziarati , B Hochwimmer , Tamayo A Zayas , Brown D Lambert
Published: July 2021

Exosomes are a novel horizon in modern therapy and open exciting new opportunities for advanced drug transport and targeted release. Exosomes are biological nanoparticles with dimensions ranging from 30 to 100 nm and are generated by all cell types in the human body. Exosomes-which are extracellular vesicles that function in intercellular communication-may play a key role in the dissemination of vaccine as well as host-derived molecules during cancer disease. We highlight the composition and function of exosomes produced during cancer disease in our work, how these vesicles could function as carriers of the RNA-peptide molecule. Finally, according to the algorithms CRUZ RODRIGUEZ (CR) we are proposing various methods to develop a novel vaccine against breast, ovarian, and lung cancers. Therefore, six RNA-peptides from our previous study were chosen based on the potential of inducing strong fusion stability (FS=58.50 cruz) and exosome affinity (EA=59.80 ro), Biological Action (BA= 1.0223 ro/cruz). This result may lead to the development of promising new therapeutic approaches in cancer management by using exosome-mediated miRNA-peptide vaccine therapy. Due to, according to the algorithm CR the Optimal Biological Action (OBA) value for antitumoral RNA-peptide with Exosome as carrier are: 0.8 < OBA < 1.3. These results suggest that the designed vaccine can elicit specific immune responses against three types of cancer; however, these results need experimental studies to confirm the efficacy and safety profile of the proposed vaccine structure.
TTK M. 1530/1 BAĞLAMINDA TİCARİ HÜKÜMLERLE YASAKLANMIŞ İŞLEMLER
Authors: KARAAHMETOĞLU İsmail Özgün
Published: July 2021

TTK m 1530/1’de ticari hükümlerle yasaklanmış işlemler hüküm altına alınmıştır. Bu hüküm uyarınca; “Aksine bir hüküm bulunmadığı takdirde, ticari hükümlerle yasaklanmış işlemler ve şartlar batıldır. Ancak, sözleşme uyarınca yerine getirilmesi gereken edimler için kanunun veya yetkili makamların koymuş olduğu en yüksek sınırı aşan sözleşmeler en yüksek sınır üzerinden yapılmış sayılır; sınırı aşan edimler hata ile yerine getirilmiş olmasa bile, geri alınır. Bu sınırlarda, Türk Borçlar Kanununun 27 nci maddesinin ikinci fıkrasının ikinci cümlesi uygulanmaz.” Görüldüğü üzere, TBK m 27/2’de hüküm altına alınan kısmi hükümsüzlük yaptırımı TTK m 1530/1 hükmünde ticari işlere özel ve kendine özgü bir düzenleme olarak karşımıza çıkmaktadır. Bu bağlamda TTK m 1530/1 hükmünün ticari işlere dair çoğu uyuşmazlıkta üstlendiği rol ve işlevin üzerinde durulması gerekir. Zira kanun koyucu kesin hükümsüzlük karşısında kısmi hükümsüzlüğün adi işlere nazaran ticari işlerde nasıl uygulanacağına ilişkin hususa ayrı bir önem vermiş olmalıdır. Bu saikle özel bir düzenleme yapma yoluna gidilmiştir. Bu da, söz konusu hükmün genel hüküm karşısındaki uygulama alanının sınırlarının çizilmesi ve açıklığa kavuşturulmasını gerektirmektedir. Bu yüzden özellikle hükmün uygulama alanının belirlenmesi noktasında eksikliği gidermek adına bir inceleme yapma gerekliliği hasıl olmuştur.
Failure of Implantation in IVF due to oxidative stress
Authors: Stavros Sofoklis , Koutras Antonios , Ntounis Thomas , Koukoubanis Konstantinos , Papalios Theodoros , Mavrogianni Despoina , Drakakis Peter
Published: July 2021

Oxidative stress may play a role in implantation failure on multiple levels. Oxidative stress is found widely in several biological systems, as well as it acts on various molecular levels with different mechanisms. It has been shown that it is rather the disequilibrium between reactive oxygen species causing oxidative stress and antioxidant mechanisms counteracting their effects, than reactive oxygen species levels themselves. Reactive oxygen species play a role in implantation and fertilisation by acting on different levels of embryo-formation and endometrial changes. Additionally, it is widely abundant in the female reproductive tract including ovaries, oocytes, tubal as well as follicular fluid. Moreover, it has been shown that male fertility is affected by reactive oxygen species by determining sperm quality. Last but not least, oxidative stress may affect IVF indirectly through its actions on peritoneal fluid. As long as research studies on elucidating the development of oxidative stress markers on patients undergoing IVF continue, ever more new possibilities emerge on predicting the pregnancy outcome.
Fetal maternal immune cross talking and vaccination during pregnancy
Authors: Masoura Panagiota , Koutsogeorgopoulou Georgia , Tsianni Diamanto , Kourtesa Anastasia , Pappa Kalliopi
Published: July 2021

Maternal adaptations in pregnancy induce complex physiological changes of the immune system which protect mother’s health and ensure the accommodation of the growing embryo. The innate immunity is amplified and the adaptive immunity is partially suppressed, preserving the ability to produce antibodies. Vaccination during pregnancy constitutes a fundamental preventive measure in the antenatal care, as it achieves both the immunization of the mother and the baby. Besides passive immunization through the placenta, also active transfer of IgG via placenta occurs throughout pregnancy. Live attenuated vaccines (LAV) are contraindicated in pregnant women, while the others should be recommended if benefits overshadow risks.
Overweight in childhood and early adulthood is associated with parental Body Mass Index and perinatal risk factors
Authors: Tambalis Konstantinos D. , Panagiotakos Demosthenes B. , Sidossis Labros S.
Published: July 2021

Background: To investigate the associations of pregnancy and pre-pregnancy parental characteristics on child’s weight and progression at the early adulthood. Material and Methods: Α random sample of 5,125 dyads children and their mothers was assessed. Mothers were asked to provide information contained in their medical booklets and pregnancy ultrasound records. With the use of a standardized questionnaire, telephone interviews were carried out for the collection of parental factors and offspring’s BMI. Results: Mother’s overweight (including obesity) before pregnancy was found to significantly increase the likelihoods of offspring’s overweight (including obesity) at the age of 8-9 years and 15-25 years (odds ratio (OR) 1.97; 95% confidence interval %CI: 1.65, 2.30 and OR 2.0; 95%CI: 1.67, 2.36, respectively). Paternal BMI (OR 1.41; 95% CI: 1.20–1.62), maternal smoking at pregnancy (OR 1.22; 95% CI: 1.14–1.30), gestational weight gain (OR 1.44; 95% CI 1.24–1.66), and gestational hypertension OR 1.30; 95% CI 1.14–1.49) were also found to significantly increase the odds of children’s obesity. Conclusion: Among prenatal factors considered, mother’s pre-pregnancy and father’s BMI, GWG, not breastfeeding, smoking in pregnancy and gestational hypertension increased the odds of offspring’s overweight/obesity in childhood and early adulthood, even after adjustment for several covariates.
First live birth in Greece after blastocyst trophectoderm biopsy and preimplantation genetic testing for hereditary angioedema
Authors: Economou Konstantinos Α. , Billi Chrysanthi , Florentin Lina , Pachydakis Anastasios , Sintoris Ioannis , Mastrominas Minas
Published: July 2021

Preimplantation genetic testing for monogenic/single-gene defects (PGT-M) is a well established tool in assisted reproduction. A couple, where the male was carrier of the c.550G>A (p.Gly184Arg) mutation of the SERPING 1 gene causing hereditary angioedema (HAE) attended our clinic for PGT-M. Employing a strategy of preserving embryos after blastocyst trophectoderm biopsy by vitrification cryopreservation, we managed to screen 10 embryos collected from a single IVF cycle. Three embryos were found unaffected after preimplantation genetic analysis for the paternal mutation. The transfer of one normal blastocyst post-thaw resulted in a healthy and uneventful pregnancy and in the live birth of a male neonate on the 38th week of pregnancy. This is the first report of a live birth in Greece after blastocyst trophectoderm biopsy and preimplantation genetic analysis for hereditary angioedema.
Exact Solution of the Schrödinger Equation for Composition of Coulomb and Oscillator Potentials
Authors: Kudryashov V. V. , Baran A. V.
Published: July 2021

The spherically symmetric potential is considered whose dependence on the distance r is described by the smooth composition of Coulomb at r < r0 and oscillator at r > r0 potentials. The boundary distance r0 is determined by the parameters of these potentials. The exact continuous solution of the radial Schrödinger equation is expressed in terms of the confluent hypergeometric functions. The discrete energy levels are obtained. The graphic illustrations for the energy spectrum and the radial wave functions are presented.
E-Health System Based on Telemedicine Platform and GRID Layer Model
Authors: Dao Van Tuyet , Ablameyko Maria , Ablameyko Sergey , Ngo Hoang Huy , Pham Thi Kim Dzung , Hoang Van Quy , Tran Van Huy
Published: July 2021

The paper describes e-Health system based on telemedicine platform and GRID layer model. We identify the currently isolated hospital subsystems that should be integrated. Telemedicine platform was proposed that was designed to enable secure management and analysis of patient data and DICOM images in a grid environment. The platform provides doctors the capacity to upload and query medical information stored over distributed servers. It was built also for sharing data between remote hospitals to help doctors in diagnosis. We propose the software components and Grid infrastructure for implementation of the Telemedicine platform and show some results of our implementation in the hospitals.
A Method of Finding Discrete Controls for Switched Dynamical Systems by Applying Continued Fractions
Authors: Khryashchev S. M.
Published: July 2021

Control systems with a finite number of control settings are considered. It is assumed that any polysystem operates in continuous time and control switchings occur at some certain discrete time instants. A control goal is to transfer a polysystem from an initial state to a final state. Controllability of systems switched in discrete time is studied. Controls are constructed by using the theory of generalized multicomponent continued fractions and the congruences theory. Applications of the proposed control method to specific systems are discussed.
Illusiveness of the Problem of Time
Authors: Cherkas S. L. , Kalashnikov V. L.
Published: July 2021

The essay is devoted to the problem of time in the context of quantum cosmology, which acquires a philosophical level to date. At an example of the minisuperspace model, we show that this problem is illusive because it does not prevent calculating the mean values of the operators over the quantum state of the universe. Contrariwise, the different approaches to the description of these time-dependent mean values give similar results.
Study of Chemical Composition of Walnut Shell Coal
Authors: Toktorbaeva G. , Tashpolotov Y. , Ysmanov E.
Published: July 2021

The article investigates the chemical composition of walnut shell coal by spectrographic and X-ray fluorescence methods. The composition of the ash content of walnut shell coal has been determined: Si, K, F, Ca, Mg, Fe, Na, Mn, Zn, Cu, I, Ba, As, Ni, etc. Carbon — 84–84.9%.
Profile of Individual Functioning With the Use of ICF for Persons With Disabilities With the Consequences of Brain Stroke in the Kyrgyz Republic
Authors: Kachybekova L.
Published: July 2021

Ratification of the Convention on the Rights of Persons with Disabilities in Kyrgyzstan in March 2019 has encouraged the country to explore the possibilities of multidisciplinary tools to assess the needs and strengths of an individual. The International Classification of Functioning, Disability and Health (ICF) is such a recognized tool. ICF allows to have complete information on any individual using a system for coding the level of disability. Further, this assessment of an individual's needs and strengths becomes the basis for rehabilitation programs for individuals with disabilities. The purpose of this study is to examine the relationship between the profile of individual functioning compiled according to ICF and medical rehabilitation programs for brain strokes using the 2020 data of certain medical and social expert commissions (MSEC) of the Kyrgyz Republic as an example, followed by the preparation of recommendations for the development of medical rehabilitation system for brain strokes. Each of the selected individual with disability was given an adapted profile of individual functioning with domains corresponding to brain strokes. Analysis of the profiles showed the possibility of using a single tool in the usual practice of the health system and medical and social examination for a more detailed assessment of functioning impairments and environmental conditions of an individual, which allowed to re-orient the rehabilitation goals. Authors revealed insufficient rehabilitation resources in Kyrgyzstan, including the availability of medical personnel and medicines with evidence-based effectiveness. Analysis of the findings allowed the authors to present recommendations for the development of a medical rehabilitation system for brain stroke in the Kyrgyz Republic.
Current State of the Labor Market and Employment Problems
Authors: Ismailov K. , Baijanov  , Bekbosinov K.
Published: July 2021

This article discusses upon the problems of employment, which are one of the main goals of the macroeconomic policy of any state. The following types of unemployment are considered in the article: frictional, structural, institutional, cyclical, voluntary. Current level of unemployment in the Republic of Karakalpakstan was studied. In conclusion, some proposals were developed to increase new job places and reduce unemployment.
On the Relevance of the Observation in the Framework of Insolvency (Bankruptcy)
Authors: Gasanov Z. , Shumov P.
Published: July 2021

The authors analyze the problem of the low efficiency of the modern observation procedure in the framework of the insolvency (bankruptcy) case. It is noted that in most insolvency cases, observation is a procedure that inhibits the opening of bankruptcy proceedings. In conclusion, it is concluded that the reduction in the overall length of proceedings may have a positive impact on the efficiency of the judicial system and to reduce the workload of judges of arbitration courts.
EFFECT OF TECHNOLOGICAL PASTURE SYSTEMS ON THE BOTANICAL COMPOSITION OF LONG-TERM GRASS STANDS AND FEED QUALITY
Authors: Privalova Kira , Karimov Ruslan
Published: July 2021

The results of long-term studies on the influence of multi-variant pasture management systems (techno-genic, integrated, technogenic-mineral, technogenic-organic) on the botanical composition and quality of feed of long-term phytocenoses are presented. The possibility of preserving the valuable botanical com-position and high quality of feed for a 75-year period under the condition of a rational mode of use and an optimal level of fertilizer is justified. All the studied systems of pasture management belong to the category of energy-saving, since with the 75-year use of grass stands, the capital costs planned for periodic re-servicing are reduced to 10 or more times. Experimental data on the botanical composition of pasture grass stands for 2005 and 2020 and the quality of green feed in terms of protein nutrition and mineral content for 1976–2020 are presented in accordance with the requirements of the technical specifications of GOST R 57482-2017 "Pasture feed". The content of seeded grasses, meadow foxtail and meadow bluegrass, in the herbage of 75 years of life against the background of N180P45K120 was 43%. The content of crude protein (at a rate of at least 14%) and crude fat (at a rate of at least 3.2%) in all studied systems exceeded the standard values.
Consensus Statements on the Approach to COVID-19 Vaccine Allergy Safety in Hong Kong
Authors: Chiang Valerie , Leung Agnes S. Y. , Au Elaine Y. L. , Ho Marco H. K. , Lee Tak Hong , Wu Adrian Y. Y. , Wong Gary W. K. , Li Philip H.
Published: July 2021

Background: Mass coronavirus disease 2019 (COVID-19) vaccination to achieve herd immunity is an effective means to mitigate the current COVID-19 pandemic. Reports of COVID-19 vaccine-associated allergic reactions and lack of clear local guidance are contributing factors leading to a low vaccine acceptance rate in the community. A task force of experts from the Hong Kong Institute of Allergy (HKIA) has been formed to address current needs.

Objective: To formulate a set of consensus statements (CS) on COVID-19 vaccine allergy safety (VAS) in Hong Kong.

Methods: A nominated task force of experts managing patients with drug and vaccine allergies in Hong Kong formulated the CS by the Delphi method. An agreement was a priori defined as ≥80% consensus.

Results: A total of 11 statements met the criteria for consensus with good overall agreement among task force members, including seven statements on pre-vaccination recommendations and four statements on vaccination and post-vaccination guidance. Individuals with a history of suspected allergic reaction to prior COVID-19 vaccination should not receive further COVID-19 vaccination, and other groups at risk of COVID-19 vaccine-associated allergic reactions have been identified. The importance of pre-vaccination and post-vaccination assessment by frontline healthcare workers and evaluation by allergists are highlighted.

Conclusion: The CS provides pragmatic and timely guidance for local frontline healthcare providers on decisions regarding COVID-19 VAS.
Overexpression of ABCG2 Confers Resistance to MLN7243, a Ubiquitin-Activating Enzyme (UAE) Inhibitor
Authors: Wu Zhuo-Xun , Yang Yuqi , Wang Jing-Quan , Narayanan Silpa , Lei Zi-Ning , Teng Qiu-Xu , Zeng Leli , Chen Zhe-Sheng
Published: July 2021

Overexpression of ATP-binding cassette transporter superfamily G member 2 (ABCG2), is known as a major mechanism mediating multidrug resistance (MDR) in cancer cells. MLN7243 is a small-molecule ubiquitin activating enzyme inhibitor currently under clinical investigation. The aim of the current study is to determine if MLN7243 is a substrate of MDR-related ABCG2 transporter. Our results showed that cancer cells overexpressing ABCG2 transporter were resistant to MLN7243 compared to the parental cells, while knockout of ABCG2 gene or pharmacological inhibition of ABCG2 efflux function completely reversed the drug resistance. Unexpectedly, the endogenous low expression of ABCG2 is sufficient to confer cancer cells resistance to MLN7243. The ABCG2 ATPase assay and HPLC assay suggested that MLN7243 can significantly stimulate ABCG2 ATPase activity and be pumped out from ABCG2-overexpressing cells by ABCG2. The docking analysis also implied that MLN7243 binds to ABCG2 drug-binding pocket with optimal binding affinity. However, MLN7243 did not competitively inhibit the efflux of other ABCG2 substrate drugs, indicating it may not serve as an MDR reversal agent. In conclusion, our study provides directin vitroevidence to show that MLN7243 is a potent ABCG2 substrate. If our results can be translated to humans, it suggests that combining MLN7243 with ABCG2 inhibitors may enhance the anticancer efficacy for patients with high tumor ABCG2 level.
Computational Insights Into the Inhibition Mechanism of Proanthocyanidin B2 on Tau Hexapeptide (PHF6) Oligomer
Authors: Li Qin , Xiong Chunmei , Liu Hongli , Ge Huizhen , Yao Xiaojun , Liu Huanxiang
Published: July 2021

The formation of amyloid fibrils from Tau is a key pathogenic feature of Alzheimer’s disease (AD). To disturb the formation of Tau aggregates is considered as a promising therapeutic strategy for AD. Recently, a natural product proanthocyanidin B2 (PB2) was confirmed to not only inhibit Tau aggregation, but also disaggregate Tau fibrils. Herein, to explore the inhibition mechanism of PB2 against Tau fibril and to provide the useful information for drug design and discovery, all-atom molecular dynamics simulations were carried out for the ordered Tau hexapeptide PHF6 oligomer in the presence and absence of PB2. The obtained result shows that PB2 can transform PHF6 oligomer from the ordered β-sheet structure into disordered one. Moreover, the clustering analysis and binding free energy calculations identify that S3 site is the most potential binding site. At S3 site, by hydrophobic and hydrogen bond interactions, the residues V309, Y310 and K311 are essential for binding with PB2, especially K311. In a word, our study reveals the molecular mechanism of PB2 inhibiting PHF6 aggregation and it will provide some valuable information for the development of Tau aggregation inhibitors.