bluuebunny/crossref_metadata_2025 huggingface dataset:
Synthesis of IONPs@β-CD by co-precipitation method at different ultrasound frequencies
Authors: Díaz-Castañon Sergio , Rivero Yuniel Rodríguez , Insausti Maite , Zabala Izaskun Gil de Muro , Lezama Luis , Rojo Teofilo , Díaz-García A.M.
Published: September 2023

In the last few decades, the use of iron oxide nanoparticles (IONPs) with magnetic properties, especially in biomedicine, has gained a great attention due to the wide range of applications of those systems in various fields. In the present work, iron oxide nanoparticles (IONPs) using β-cyclodextrin (β-CD) as capping agent were synthesized by normal co-precipitation and reverse co-precipitation methods. Syntheses were made at 25 kHz y 45 kHz and without ultrasound for both methods. As-synthetized IONPs were characterized using Fourier transform infrared spectroscopy (FT-IR), X-ray powder diffraction, thermal analysis, scanning electron microscopy, transmission electron microscopy, dynamic light scattering (DLS) and electrophoretic light scattering (z potentials). The analyses of vibration sample magnetometer confirmed that the nanoparticles have magnetic properties. Differences in particle size, organic coating degrees, and magnetization values for normal and reverse co-precipitation methods for obtained IONPs were observed. The particle size determined by Scherrer equation, SEM, TEM and DLS was increased at 45 kHz for both methodologies. The z potentials nearby ˗30 mV suggest that nanoparticles dispersion are moderately stable from aggregation. Potential use a platform for magnetic separation of IONPs modified with β-CD obtained by normal co-precipitation method in this work, are analyzed by FT-IR spectroscopy, using as a model IBF, taking in account the formation of inclusion complex between this molecule and the β-CD on the surface of IONPs.
A phase 1 dose-escalation study of low-dose lenalidomide maintenance post-allogeneic stem cell transplantation for high-risk acute myeloid leukaemia or myelodysplastic syndrome
Authors: Ritchie David , Koo Ray Mun , Wong Eric , Davis Joanne , Perera Travis , Lim Andrew Boon Ming , Koldej Rachel
Published: September 2023

Immunomodulatory strategies to promote the graft-versus-leukaemia (GVL) effect following allogeneic stem cell transplantation (alloSCT) may precipitate graft-versus-host-disease (GVHD). We hypothesise that low-dose lenalidomide may be tolerable whilst still being able to augment GVL. We conducted a phase 1 study of post-alloSCT low-dose lenalidomide maintenance for patients with high-risk acute myeloid leukaemia or myelodysplastic syndrome. The primary objective was to determine the maximum tolerated dose (MTD). Secondary objectives were treatment efficacy and assessment of immune reconstitution. Lenalidomide was commenced from day 40–45 post-alloSCT for up to 12 months. Fifteen patients were recruited. The highest lenalidomide dose was 5mg alternate daily, however the MTD was not reached due to early study termination from poor recruitment. Four dose-limiting toxicities were encountered, of which 3 were grade III acute GVHD. Of the 6 patients who died, 5 were due to relapsed disease. The incidence of acute GVHD was 33% and chronic GVHD at 1-year was 19%. One-year relapse-free survival and overall survival were 60%. Despite the low dose of lenalidomide, NK and T cell immune reconstitution was improved at day 100 post-alloSCT. Low-dose lenalidomide maintenance post-alloSCT resulted in acceptable GVHD risks with demonstrable impacts on immune reconstitution, meriting further investigation as a relapse-prevention strategy.
Object Detection In Low-Light Environment Using YOLOv7
Authors: Al-refai Ghaith , Elmoaqet Hisham , Ryalat Mutaz , Al-refai Mohammed
Published: September 2023

Object detection in low-light conditions is very essential in many applications such as autonomous driving, surveillance and security systems. Deep learning and neural networks are widely used in object detection applications, many algorithms were modified to improve the detection in low-light environments. You Only Look Once (YOLO) is one of the latest computer vision algorithms that provides accurate object detection and optimized algorithm run-time. In this work, the latest YOLO algorithm (version 7) is trained and validated using Exclusively Dark Image Dataset (ExDark) to detect twelve classes in dark environments. Results are displayed and compared with the latest related research work in this field. The detection precision and recall are 0.7153 and 0.6556 respectively. YOLOv7 showed a major improvement in the mean average precision (mAP) over a previous recent work who used the same dataset.
Tandem Autologous Stem Cell Transplantation Improve Outcomes in Multiple Myeloma Patients with high risk factors: A Systematic Review and Meta-Analysis
Authors: Chen Haifei , Qin SiBer , Zhou Lingyun , Liu Yusi , Zhang Peng , Zhou Qionglin , Xu Xiayan , Liu Danbo , Du Fang , Chen Jiao , Cao Weiling
Published: September 2023

Background
This study aims to conduct a systematic review and meta-analysis to assess the differential effects of tandem or single autologous stem cell transplantation (HDT/ASCT) in multiple myeloma (MM) patients.
Methods
A systematic literature searched was performed on Pubmed, Cochrane, Embase. RCTs comparing single HDT/ASCT with or without consolidation therapy and tandem transplantation were included into network meta-analysis.
Results
A total of 8 RCTs was included into meta-analysis. The combined HR was 0.58 (95% CI: 0.43 to 0.80, P = 0.001) and 0.70 (95%CI: 0.54 to 0.90, P = 0.006) indicating tandem HDT/ASCT might significantly PFS and OS benefit for patients with at least one adverse factor. Results of network meta-analysis indicated there was no significant effect between tandem HDT/ASCT and single HDT/ASCT with consolidation therapy for PFS and OS. Tandem HDT/ASCT could reach a statistically significant VGPR or better response benefit compared with single HDT/ASCT (RR = 1.18, 95% CI: 1.05 to 1.32, P = 0.006). No significant difference in the risk of TRM between tandem HDT/ASCT and single HDT/ASCT group.
Conclusions
The results of meta-analysis showed a superior PFS and OS with similar safety among tandem HDT/ASCT and single HDT/ASCT in high risk patients. Tandem HDT/ASCT might be considered as an alternative for high risk patients.
Glans Hypermobility Scale (GHS) Score: a Simple and Reliable Grading Scale for Glanular Hypermobility.
Authors: Kohler Tobias , Ziegelmann Matthew , Mian Abrar , Dodge Nicole , Mian Raza , Helo Sevann , Suarez-Sarmiento Alfredo , Brennan Matthew , Perito Paul
Published: September 2023

Glans hypermobility (GH) is a well-described clinical entity that can have significant implications for cosmesis and function, resulting in sexual dissatisfaction, penile pain, and early device erosion, with an estimated incidence of 0.04–10%. We developed a novel grading scale to assess GH severity intraoperatively during primary inflatable penile prosthesis (IPP) placement and describe a modified glanspexy technique to correct GH when encountered during IPP placement. A total of 530 patients underwent primary device implantation. Of these, 139 (26%) had hypermobility. Employing our new scaling system, grade 1, 2, and 3 GH was seen in 86 (16%), 29 (5.5%), and 24 (4.5%) cases, respectively. Increased implant size correlated with decreased likelihood of GH incidence. Each increase in implant size by 1 cm decreased the incidence of detecting GH by 11% (OR = 0.89; p = 0.015). 11 patients underwent primary GH repair using our described technique. At one-year follow-up, one patient required repeat glanspexy for recurrent bothersome GH and a second patient developed a suture granuloma at the glanspexy incision requiring unilateral cylinder explant. Our modified glanspexy technique can be used to correct GH in any direction and is a useful tool for the prosthetic surgeon’s armamentarium.
How do we treat psoriatic arthritis in the era of GRAPPA recommendations: predictive factors for bDMARDs usage in PsA patients in a real life setting
Authors: Ferraioli Mario , Conigliaro Paola , Fatica Mauro , D'Antonio Arianna , Ferrigno Sara , Scriffignano Silvia , Triggianese Paola , Perrotta Fabio Massimo , Greco Elisabetta , Bergamini Alberto , Lubrano Ennio , Chimenti Maria Sole
Published: September 2023

Psoriatic arthritis’s therapeutic approach has recently improved, as indicated by the recent GRAPPA recommendations, since the introduction of bDMARDs with different targets. Purpose of this study was to evaluate usage of PsA recommendations for bDMARDs selection based on baseline predictive factors. A retrospective study was conducted on bDMARD-naïve patients, in stable condition. Study population was divided in two groups based on the period they started treatment: between January 2006-December 2013 and between January 2014-December 2022. Then, impact of clinical PsA features and comorbidities was evaluated as an influencing factor in bDMARD selection. 146 patients were included in the 1st period (all receiving TNFi) and 250 in the 2nd (175 received TNFi and 75 ILi). Comparing only TNFi treated patients, subjects treated in the 2nd period presented less frequently PsO, enthesitis, poly-arthritis, bone erosions, CV risk factors, while those presenting PsO familiarity, oligo-arthritis and axial involvement resulted more frequently treated. Comparisons of patients treated in 2nd period with TNFi and ILi resulted that those presenting PsO, nail PsO, axial involvement and CV risk factors were more frequently treated with ILi while those presenting bone erosions with TNFi. Therefore, it is possible to speculate that PsA clinical features/comorbidities may influence treatment choices.
How important is natural selection respect to environment change in driving financial markets?
Authors: Fort Hugo
Published: September 2023

A central challenge in evolutionary economics stems from the fact that fitness values are not static quantities but typically fluctuate over time. Based on the longstanding tradition of rigorous mathematical description of evolution in population genetics, we propose a quantitative implementation of fluctuating selection to explain the dynamics of firms’ market capitalizations. We thus estimate the Malthusian fitness of a company from a time series of its market cap. Next, the Fisher/Price theorem allows us to decompose the time variation of mean fitness into a “selection” term and an “environment change” term. The latter encompasses all time changes of fitnesses (due to innovation of firms, changes in economic policy, etc.)
We apply this Fluctuating Selection from Market Caps (FSMC) approach to daily market capitalizations of public-owned Fortune 100 companies across 2000-2021. The main findings are: Firstly, most of the change in mean fitness is explained by the environment change. Secondly, the smaller effect of selection has been mainly circumscribed to the three recessions that occurred between 2000 and 2021. Thirdly, recessions were characterized by drops in mean fitness. We conclude by deriving an equation for the evolution of market concentration that explains the observed trend towards greater concentration.
JEL codes: B52, C51, C52, C53, C63, G17
Temporary and Spatial Analysis of Lightning Density in Türki̇ye
Authors: ÇİÇEK İhsan , TÜRKOĞLU Necla , DEMİRÖRS Zerrin , GÖZET Edanur , YILMAZ Batuhan Ateş , ALAN İlker
Published: September 2023

The electrical discharge occurring due to ascending and descending air movements between the ground and the atmosphere is called lightning. Lightning from cumulonimbus (Cb) clouds occurs as intercloud (IC), cloud-to-cloud (CC), or cloud-to-ground (CG). In the present study, both meteorological parameters (ground temperature, moisture content due to sea effect) and geographical features (latitude-longitude and altitude) were addressed in the spatial analysis of lightning density in Türkiye. The temporal analysis of lightning density was performed hourly, monthly, seasonally, and annually. The lightning data used in the study were obtained from the Türkiye State Meteorological Service (TSMS). ArcGIS version 10.4.1 was used as GIS software. When the annual lightning density was evaluated by regions, the highest values were observed in the Inner Aegean, Marmara, Muğla-Antalya, Western Black Sea, and Eastern Anatolia Regions. The Central Anatolia Region is the region with the lowest lightning density. Lightning density is also highest in late spring-early summer when the ground temperature and, thus, instability are highest. May and June were determined to be the months with the highest lightning density, whereas December, January, and February were the months with the lowest lightning density. Considering lightning activity hourly, the highest number of lightning strikes occurred at noon, and the lowest number occurred at night and morning hours. Upon examining the relationship of lightning with latitude and longitude values, it was concluded that the relationship with latitude values was more significant and positive. Lightning increases as a function of altitude between 30-150 m and 500-1000 m altitude, while it decreases as a function of altitude between 150-500 m and above 1000 m altitude.
Effect of basket depth and stocking density on production of the sea urchin Tripneustes gratilla: insights and recommendations
Authors: Vos Bas C. , Cyrus Mark D. , Bolton John J. , Macey Brett M.
Published: September 2023

Basket depth and stocking density are crucial and related factors for successful commercial sea urchin aquaculture, but these factors have not been definitively determined for production of Tripneustes gratilla. This study investigates the effects of varying basket depths (deep 35cm vs. shallow 10cm) and stocking densities (4, 6 and 8kgs.m− 2 or 13, 19 and 24% coverage of available basket surface area) on urchin production. Contrary to previous suggestions, reduced consumption was identified as the cause of decreased production in deeper baskets. Consumption was significantly higher in shallow baskets than deep baskets for both the fresh seaweed, Ulva lacinulata, (W = 38, p = 0.026) and formulated feed (W = 76.5, p = 0.007). Consequently, baskets of approximately 10cm deep are recommended to enhance production of T. gratilla and possibly other urchin species. Two subsequent trials assessed T. gratilla production at different stocking densities. Trial 1 aimed to maximize urchin size over a three-month grow-out period using fresh U. lacinulata, while trial 2 focused on enhancing gonad production over two months using formulated feed. Although greater stocking density significantly reduced the specific growth rates of individual urchin mass in both trials (p < 0.044), there was no significant impact on mortality, net production or gonad size and quality. The variations in growth rates were attributed to spine loss resulting from negative behavioural interactions (F2, 9= 9.551; p = 0.005). Based on the objectives of both grow-out and gonad-enhancement phases, we recommend a stocking density of approximately 20% coverage.
Transient Hydromagnetic Maxwell Fluid Flow over Inclined Stretching Surface with Thermal Radiation, Viscous Dissipation and Ohmic Heating Effects
Authors: Opanuga Abiodun A. , Agboola Olasunmbo O. , Okagbue Hilary I. , Olajide Ibikunle
Published: September 2023

Analysis of an electrically conducting two-dimensional Maxwell fluid flowing through an inclined stretching sheet is considered in this work. Incorporating the viscous dissipation and Ohmic heating effects on the time-dependent optically dense fluid, and using the required similarity transformation variables, the equations governing the flow are deduced and converted into a coupled system of ordinary differential equations. Runge-Kutta fourth order scheme with shooting technique is applied to solve the derived equations. Plots and tables are employed to explain the flow parameters for fluid velocity, temperature, and concentration profiles as well as the skin friction, local Nusselt number, and local Sherwood number. Increase in the angle of inclination parameter, Hartmann number, Prandtl number and Schmidt number reduce the magnitude of the fluid velocity, while radiation parameter, Grashof and Eckert numbers increase it. However, fluid temperature is significantly moderated by Grashof and Prandtl numbers.
Exploring the Biotechnological Potential of Endophytic Fungi from Acorus calamus: Enzymatic Activity, Antimicrobial Properties, and Siderophore Production
Authors: Parki Prabha , Verma Himani , Rana Babita , Khulbe Kapil
Published: September 2023

The leaves and rhizome of Acorus calamus (Acoraceae) were investigated for the endophytic fungi associated with the plant. Two fungal endophytes were isolated and confirmed as Cladosporium sphaerospermumand Plectosphaerella sp. using molecular techniques. Both species were recorded as new isolates of A. calamus. The isolates were tested for extracellular enzyme production. The Plectosphaerella sp. demonstrated enzymatic activity in maximum instances, whereas C. sphaerospermum displayed positive results for three extracellular enzyme production (pectinase, cellulase, and tyrosinase) activities. The preliminary siderophore production assay was done, and Plectosphaerella sp. was found to have the potential for siderophore production. Both fungal isolates were screened for preliminary antibacterial activity by the agar-well diffusion method against plant and animal pathogens, in which C. sphaerospermumshowed the maximum zone of inhibition against the animal pathogenic Bacillus megaterium (30.67 ± 1.64) while Plectosphaerella sp. against Staphylococcus aureus(16.67 ± 1.20). When tested against plant pathogenic strains, C.sphaerospermum showed the maximum zone of inhibition against Xanthomonas phaseoli (31.50 ± 1.76) and Plectosphaerella sp. against Xanthomonas campestris (15.33 ± 0.88).
Financial conflicts of interest among authors of clinical practice guideline for diabetes mellitus in Japan between 2016 and 2020
Authors: Murayama Anju
Published: September 2023

Aims:
To assess the financial relationships between pharmaceutical companies and authors of the Japanese Clinical Practice Guideline for Diabetes 2019.
Methods:
Retrospective analysis of publicly available pharmaceutical-industry personal payments evaluated size and prevalence of financial relationships between all 27 authors of the CPG and pharmaceutical companies in Japan. Personal payments from pharmaceutical companies to the authors between 2016 and 2020 were extracted from publicly disclosed database and each pharmaceutical company.
Results:
Of all 135 authors of clinical practice guideline for diabetes mellitus developed by the Japan Diabetes Society in 2019, 129 (95.6%) received personal payments from pharmaceutical companies between 2016 and 2020. The total amounts of personal payments were $23,130,423, with a median of $89,955 and an average of $171,336 per author. More than 74.1% (100 authors), 60.7% (82 authors), and 47.4% (64 authors) received more than $10,000, $50,000, and $100,000 personal payments in total over the five years, respectively. The guideline chairpersons of the guideline development and review committees received substantial amounts of personal payments from the companies during the guideline development period.
Conclusion:
Nearly all guideline authors received substantial amounts of personal payments from pharmaceutical companies during the guideline development period and one year after its publication. Nevertheless, the Japan Diabetes Society roughly managed their COIs, and many authors self-declared no financial COIs with pharmaceutical companies even though they received moderate amounts of personal payments. These findings underscore the urgent need for policy interventions to enhance transparency, integrity, and reliability in the development of clinical practice guidelines in Japan.
Influence of CerS on T cell function and colitis
Authors:   , Hartel Jennifer
Published: September 2023

Sphingolipids are not only structural components of cell membranes but can also act as signalling molecules in different pathways. Sphingolipid precursors, Ceramides (Cer), are synthesized de novo by six different synthases (CerS1-6) which generate Cer of different chain lengths. Cer can be further synthesized to glycosphingolipids and sphingomyelin. Cell membrane parts that are enriched in glycosphingolipids are so-called lipid rafts and can function as signalling platforms for different receptors, such like the T cell receptor (TCR). CD4+ T cells play a crucial role in the development of ulcerative colitis, a chronic inflammatory disease of the colon. As CerS3 expression was increased in the white blood cells of human colitis patients, the role of CerS3 in the TCR signalling and colitis was investigated in this dissertation. By lenti-viral transduction of a CerS3-shRNA into a CD4+ Jurkat cell line, it was shown that CerS3 has an impact on activated T cells. A decrease of different sphingolipids after T cell activation via CD2/3/28 activation beads and IL2 treatment was observed that was accompanied by an inhibition of Zap70 phosphorylation, an important protein of the TCR signalling. The impaired TCR signalling led to a diminished NFAT1 translocation into the nucleus which subsequently led to a reduced NFAT1- dependent TNFα release. Downregulation of CerS3 in primary CD4+ T cells, obtained from the blood of healthy volunteers, also showed a reduced release of pro-inflammatory cytokines after activation. This dissertation demonstrates a pivotal role for CerS3 in T cell function and highlights CerS3 as potential new target for T cell driven colitis.
Innovations and Tourism Regions: are Innovations Perceived as A Problem in Regional Development in European Tourism?
Authors: Kubickova Viera , Labudova Viera , Benesova Dana , Mura Ladislav
Published: September 2023

This article examines innovative aspects of the development of tourism regions in Europe. The article aims to determine the intensity of the perception of innovation in the tourism region as a problem in its development. The ambition of the article is to assess the problems in the development of tourism regions in Europe in the field of innovation as a possible starting point for optimizing changes in local and regional tourism policy. The research analyses the positions of 95 regional tourism experts from 17 European countries. The database was based on a databank of 150 representatives of academia and 275 representatives of regional tourism organizations. To analyse the properties of categorical data and the relationships between them, we used Gamma, Kendall’s Tau-b, Somers’ D C|R, Spearman correlation coefficient, Phi Coefficient, Contingency Coefficient, Cramer’s V and the decision tree algorithm. The maturity of the innovation environment of tourism regions and their level of development influence the perception of innovations as a problem in their development. Southern European tourism regions perceive innovation as a problem in their development most intensively. Tourism regions with stronger innovation activity have a well-established quality management system and a comprehensive and systematically addressed supply of seasonal and off-season products. Tourism regions ranked in the emerging innovator group perceive the specified problems in the implementation of innovations more intensively. This reflects the lack of coordination of the product portfolio, both in terms of range and quality, in countries where the innovation environment is poorly developed. A key recommendation to mitigate the perception of innovations as a problem in the development of Europe’s tourism regions is to focus attention on the implementation of regional policy instruments that stimulate the participation of tourism in the synergy effects of the existing innovation environment of the economy.
Nothing Stays the Same: A Typology of Markers and Functions of Reimagination
Authors: SF. Luthfie Arguby Purnomo  , Wildi Adila  , Shabrina An Adzhani
Published: September 2023

Reimagination has become a common practice in milking the revenues of comics, animated films, films, and games that experienced a past glory. However, the discussions over reimagination specifically on its markers and a typology of functions remain under investigated. In response to this gap, we investigated 31 reimagined titles from comics, animated films, films, and games by implementing the theories of space and place reimagination by Richardson (2012), the death of the reader by Gray, Sandvoss, and Harrington (2007), transtylisation by Genette (1997), and narrative identity by Ricoeur (1991). The findings indicate that reimagined works have two shared markers namely mutation and presentness on the textual, visual, and operative elements of the works. Mutation deals with the alterations of the three elements while preserving the core narrative identity of the works while presentness refers to the adjustment of the three elements in chronospatial context of the present time. The investigated works also indicate that six reimagination functions could be formulated. Those functions are stylistic, ludic, methectic, medial, branding, and cultural reimaginations.
Мутационный профиль генома нормальных и опухолевых клеток у больного множественной миеломой (клиническое наблюдение)
Authors: Жук А. С. , Кострома И. И. , Степченкова Елена Игоревна , Качкин Д. В. , Белопольская О. Б. , Зотова И. В. , Гарифуллин А. Д. , Волошин С. В. , Грицаев С. В. , Аксенова А. Ю.
Published: September 2023

This paper is a case report of a patient with newly diagnosed multiple myeloma (MM) who underwent exome sequencing of peripheral blood lymphocytes and CD138+ tumor plasma cells prior to therapy. This patient showed some inherited genetic variants which are associated with underlying risk for MM. This patient’s genotype was reported to have some variants in the DNA repair genes, including inherited mutations in the RFDW3 and TP53 genes. They are involved in the maintenance of genome stability and accumulation rate of somatic mutations, including structural rearrangements and chromosome aberrations. A large number of structural variations

and mutational signature ID6 in the tumor genetic material point to the disruption of DNA damage repair. The tumor cell exome analysis yielded a profile of somatic mutations, also the mutations in the genes previously associated with MM, as well as a functional significance of the detected abnormalities. Somatic mutations also included damaging mutations and highly significant mutations in the other tumor-associated genes, such as ASCC3, TET3, and CHD1, as well as in the antimicrobial peptide-coding genes CAMP and HTN3. With the exception of an extra copy of 1q arm in the tumor plasma cell genome, the patient showed no genetic risk factors associated with poor prognosis of the disease. Based on literature, inherited (ABCB1 mutations) and somatic (trisomy 3) variations detected in the patient’s genetic material can be characterized as positive prognostic factors in MM.
Complex skin care for psoriasis: effective control with modern dermatocosmetic products
Authors: Zhukova O. V. , Artemyeva S. I.
Published: September 2023

Introduction. Recent decades have witnessed significant progress in the dermatocosmetic industry, driven by increased knowledge of  skin physiology, development of  new active ingredients and products based on well-studied action mechanisms. Dermatovenerologists actively use dermatocosmetics in inflammatory skin diseases, which include psoriasis. Even in mild forms, psoriatic rashes can be accompanied by itching and flaking. A significant proportion of patients have lesions on exposed skin, and the disease has a severe psychosocial burden. Full and successful control of psoriasis requires the use of adjuvant agents, which can be used alone to maintain remission or as an adjunct to medication, also reducing the negative effects of treatment. The Kertyol P.S.O. Ducray range is represented by products containing active components with anti-inflammatory, antipruritic, keratoregulatory action.

Aim. To evaluate the effectiveness of including the Kertyol P.S.O. Ducray range of products in the treatment regimen of patients with psoriasis.

Materials and methods. 20 patients with localization of psoriatic rashes on smooth skin and scalp were included in the study. Kertyol P.S.O. Ducray concentrate in combination with calcipotriol was recommended for smooth skin rashes, and daily skin care was corrected; Kertyol P.S.O. Ducray concentrate and regenerating shampoo in  combination with calcipotriol/betamethasone dipropionate were recommended for scalp skin.

Results. At the 4th week of therapy the average reduction of PASI index in the complex evaluation of clinical manifestations amounted to 89.6%; antipruritic effect was determined by the dynamics of VAS – the average reduction of the index at the 4th week amounted to 90.6%. Dermatologic life quality index (DLQI) decreased by 89.5% at the 4th week of therapy.

Conclusion. Kertyol P.S.O. Ducray products can be recommended as an effective adjuvant therapy for smooth skin and scalp psoriasis.
Alterations in IL-17 expression in pediatric patients with psoriatic arthritis
Authors: Chebysheva S. N. , Sobolev V. V. , Geppe N. A. , Soboleva A. G. , Korsunskaya I. M.
Published: September 2023

Introduction. Psoriatic arthritis is a common inflammatory disease affecting the joints and it is usually accompanied by plaque psoriasis. The pathogenetic link between psoriasis and psoriatic arthritis well reflects the mechanistic hypotheses of disease pathogenesis. Psoriatic arthritis is characterized by chronic inflammation which results in bone erosion and bone loss, as well as new bone formation around the affected joints. The exaggerated inflammatory response leads to enthesitis with the crucial contribution of IL-17 producing T cells and entheseal resident cells, expressing IL-23R. Studying the IL-17 gene expression patterns can help choose a therapy for patients with psoriatic arthritis.

Aim. To study alterations in IL-17 gene expression in immune cells of paediatric patients with psoriatic arthritis.

Materials and methods. Mono nuclear cells were isolated from the peripheral blood of 45 patients with psoriatic arthritis and 20 healthy controls. The IL-17 gene expression was analysed using a real-time PCR.

Results and discussion. Mononuclear cells were isolated from whole peripheral blood for subsequent analysis of IL-17 gene expression by quantitative RT-PCR. The comparative analysis of the expression levels of patients with psoriatic arthritis and healthy volunteers showed that the expression level of IL-17 gene in patients with psoriatic arthritis was 345 times higher than the expression level in healthy volunteers.

Conclusion. Patients with psoriatic arthritis are characterized by a very high level of IL-17 gene expression in immune blood cells. The high IL-17 gene expression level confirms its significant role in the inflammatory process in patients with psoriatic arthritis.
Development of Biology E-Module Based on POGIL in Virus and Bacteria Material to Train HOTS X Graders of Senior High School
Authors: Ningsih Ani Widia , Hidayatullah Ahmad Fauzan , Rofi’ah Ndzani Latifatur
Published: September 2023

Higher-Order Thinking Skill (HOTS) is a skill that every individual needs to be able to solve problems quickly, critically, and logically. The condition of HOTS in Indonesia is still low. This study aims to create and assess the feasibility of E-module biology based on POGIL on viral and bacterial materials. This study uses the 4D development model (Define, Design, Develop, and Disseminate but is limited to the Development stage. The product trial sample on 42 science students of grade X was taken randomly. The validation results from media experts, POGIL experts, material experts, HOTS experts, and biology teachers, namely, 83.3%, 85%, 82.5%, 86.2%, and 88.6%. The overall results from the expert validation are of very decent quality. The student's responses regarding the E-module based on POGIL on the virus and bacteria material obtained a mark of 85.3%, which included the very decent category. E-module is a feasible type to be applied as a learning resource for X senior high school grades.
Microbial Biomass as a Bioresource of Functional Food Ingredients: A Review
Authors: Serba Elena , Yuraskina Tatyana , Rimareva Liubov , Tadzibova Polina , Sokolova Elena , Volkova Galina
Published: September 2023

Microbial biomass is a promising source of essential macro- and micronutrients to be used in the food industry, e.g., protein, vitamins, essential amino acids, polysaccharide, etc. This article reviews scientific publications on the properties and composition of microbial biomass as a source of functional ingredients, its biological effectiveness, production methods, and composition.

The review covered research articles published in 2005–2021 and indexed in eLIBRARY.RU, Google Scholar, Scopus, Elsevier, and PubMed. It relied on such general scientific methods as analysis, generalization, and systematization.

Saccharomyces cerevisiae yeast and Aspergillus mycelial fungi appeared to be the most popular research objects. Most studies concentrated on the chitin-glucan-mannan complex of cell walls and protoplasmic biovaluable protein. Others featured the biocatalytic conversion of microbial polymers with the transfer of biologically valuable components into an enzyme-accessible state. Bioactive ingredients of microbial origin could be divided into sorbents, immunomodulators, neurotransmitters, antioxidants, and anticarcinogenics.

Microbial fermentolysates are a potential source of bioactive compounds for functional foods. However, the medical and biological properties of their minor bioactive components remain understudied while fermentolysates can yield new functional products fortified with essential amino acids and low-molecular bioactive peptides.
Teoria da consciência em Simone de Beauvoir
Authors: Lindenmeyer Luciane Luisa
Published: September 2023

Neste artigo, busco elementos conceituais presentes em O Segundo Sexo para a formulação de uma teoria da consciência propriamente beauvoiriana. A sua própria teoria da consciência foi, pode-se dizer, ofuscada teoricamente pelas teses de grandes autores como Sartre, Merleau-Ponty e mesmo Bergson. É claro que não é possível dissociá-los por completo do pensamento de Beauvoir. Apesar disso, pretendo rastrear os elementos conceituais próprios da fenomenologia de Beauvoir. Se há uma teoria da consciência especificamente beauvoiriana ela só pode ser caracterizada a partir de conceitos que compõem a sua análise da condição existencial da mulher, isto é, conceitos como os de socialização e de eterno feminino. Com esses termos técnicos, Beauvoir fundamenta a sua crítica à pretensa impessoalidade fenomenológica que pode ser reconstituída até a fenomenologia clássica de Husserl. Não há, portanto, como pensar uma teoria da consciência satisfatória, sem considerar a desproporcionalidade entre mulheres e homens, no que se refere à constituição da consciência de si.
Rousseau e a radicalidade democrática
Authors: Moscateli Renato
Published: September 2023

A associação de Rousseau às fontes filosóficas da democracia não constitui algo livre de discussões. O próprio autor preferia a qualificação de “republicano” em vez de “democrata”, e no Contrato Social apontou sérias dificuldades para a existência da democracia como uma forma de governo, ainda que suas teses sobre a soberania popular reverberem princípios tipicamente ligados às constituições democráticas. Diante disso, Kevin Inston questionou que os democratas radicais contemporâneos tenham negligenciado a contribuição do filósofo genebrino, e por isto buscou mostrar o quanto ela continua sendo relevante para enfrentar os desafios políticos da atualidade. Todavia, em que medida se sustentam os esforços de Inston para compatibilizar a teoria política rousseauniana com a democracia contemporânea? Não terá o comentador subestimado ou ignorado elementos cruciais que tornam tal convergência problemática? O objetivo deste artigo é tentar fornecer algumas respostas para tais perguntas.
Que é isto - a Filopsicodelia?
Authors: Costa de Freitas Jan Clefferson
Published: September 2023

Os principais objetivos do presente artigo são: a) rememorar os precedentes e explicar os desdobramentos do conceito de psicodelia através da história da filosofia; b) apresentar as evidências que definem como psicodélico não apenas o efeito de substâncias transformadoras da mente, mas também um conjunto integrado de práticas místicas, um espectro amplo de estados conscienciais e um movimento contracultural de natureza libertária; c) identificar as aproximações possíveis entre a filosofia e a psicodelia a partir do horizonte da estética visionária, da fenomenologia perceptual, da epistemologia consciencial, das éticas da resistência, das políticas da liberdade e da metafísica originária; e d) interpretar o reflorescimento do pensamento psicodélico como filopsicodelia, ou seja, uma análise das ideias filosóficas a partir da experiência psicodélica e uma descrição da experiência psicodélica a partir dos conceitos filosóficos.
Habitação de Interesse Social e acesso à terra urbana
Authors: Gomes Reis Lopes Wilza , Martins Ribeiro de Carvalho Ilana , Cardoso Façanha Antonio , Cardoso Matos Karenina
Published: September 2023

O modelo de urbanização brasileiro resultou em espaços com características diferenciadas quanto à renda dos habitantes e disponibilidade de infraestrutura. No caso da cidade de Teresina, nas últimas décadas do século XX, já se percebia a presença das desigualdades sociais, elemento comum às demais cidades brasileiras. Parte deste contexto resulta da produção de conjuntos habitacionais em espaços periféricos, que contribuem para o espraiamento da malha urbana e para fenômenos como especulação imobiliária e segregação espacial. Exemplo disto pode ser ilustrado na construção do Residencial Jacinta Andrade, situado em Teresina, Piauí, o maior conjunto de Habitação de Interesse Social (HIS) da cidade, destinado à provisão de 4.000 moradias para famílias de baixa renda, obra do Programa de Aceleração do Crescimento (PAC). Neste artigo foram analisadas as necessidades e percepções dos moradores do residencial Jacinta Andrade, na cidade de Teresina, sobre condições de moradia, infraestrutura e serviços urbanos ofertados, utilizando-se de formulários aplicados a 103 residentes, que foram aprovados pelo Comitê de Ética em Pesquisa (CEP). Foi constatado que a habitação, foi avaliada, de forma positiva, embora, isto pode ser resultado da sensação de segurança, proporcionada pelo imóvel próprio, e não, à qualidade de vida promovida pelo conjunto habitacional. Quanto à Infraestrutura e Serviços, aspectos como abastecimento de energia elétrica e coleta de lixo surpreenderam ao satisfazer mais de 85% dos moradores. Em relação à Segurança, foi observada a presença de áreas de lazer e de equipamentos públicos, embora tenham sido avaliadas de modo negativo, por mais de 83% dos residentes.
ARQUITETURA DE INTERIORES AMIGÁVEL A CRIANÇA COM TRANSTORNO DO ESPECTRO AUTISTA: ADAPTAÇÃO DE DORMITÓRIO
Authors: Barbosa da Silveira Rodrigues Lucas , Oliveira da Silva Robson , Fernandes Andrade Isabela
Published: September 2023

Este trabalho foi constituído acerca da experiência de projetar a arquitetura de interiores de uma residência unifamiliar, com estrutura familiar composta por mãe, pai e filho, na qual este possui diagnóstico de Transtorno do Espectro Autista (TEA). O objeto de estudo trata-se do processo projetual de interiores para a reforma do dormitório infantil, que era subutilizado pela criança em decorrência das incompatibilidades do espaço físico com as suas características como criança e como pessoa com TEA. No processo de projeto, algumas soluções foram implementadas através de uma metodologia empática ao usuário e fundamentada na literatura que trata sobre autismo e desenvolvimento infantil. Como resultado desse processo, o dormitório reformado permitiu apropriação pela criança, o que representa um referencial de projeto de sucesso. Como as normas de acessibilidade das edificações não fazem luz sobre como projetar para autistas, este trabalho pode ser um auxílio para projetistas que necessitem conhecer modelos de projetos amigáveis às pessoas com TEA.
Developing System of Indicators Estimating Bankruptcy Possibility for Public Catering Organizations within the Frames of Crisis Management
Authors: Malinovsky R. O. , Anisimov A. Yu.
Published: September 2023

Developing the optimum crisis strategy depends mainly on the quality of analytical base, which is built in the process of finance analysis and diagnostics of organization bankruptcy. It is connected with organizations of public catering as well. Today issues of shaping the optimum set of indicators to estimate bankruptcy possibility have not been clarified so far. Thus the necessity of investigations in the field is stipulated by debatable nature of accounting for sectoral peculiarities in the current assessment methods. The goal of the research is to identify specific features of building the system of indicators for estimating bankruptcy possibility in public catering organizations. Such research methods as comparative analysis, statistic analysis, correlation analysis, bench-marking, classification and ranking were used, as well as the modified method of hierarchy analysis. As a result of the research academic and practical recommendations were put forward dealing with developing the system of indicators for estimating bankruptcy possibility in public catering organizations. The authors came to the conclusion that the optimum system of indicators for estimating bankruptcy possibility could foster the development of efficient strategy of crisis management.
Variation Approach and Principle of Maximum in Theory of Dynamic Systems
Authors: Proskuryakov A. Yu.
Published: September 2023

The article shows dynamics of value figures on market of digital finance assets. The research studies methods of the sensitivity theory in tasks of optimal management of non-linear systems for automated monitoring and controlling the portfolio of digital finance assets and crypto-currencies. The authors study process modeling in economic systems, set the task of optimal management by the system of non-linear differential equations and target functionality, describe the variation method of task resolving, the principle of invariability of non-linear systems and possibilities to model economic systems provided by the solution. The approach to investigating dynamics of economic systems based on the principle of maximum was analyzed. The article shows possible application of the approach for resolving optimization tasks and for methods of management with split and continuous character in conditions of uncertainty typical of economic systems. Functions of non-linear sensitivity are identified. The use of the sensitivity theory for tasks of optimal management of non-linear systems was studied, illustrated by estimating the vector of unknown parameters of dynamic system. The authors analyze the condition in tasks of economic modeling with regard to uncertainty caused by social and psychological reasons. The material provided in the article shows possibilities of using the method of sensitivity analysis for tasks of system decomposition and related transformations in systems of differential equations.
Key Trends in Pursuing Industrial Policy in Conditions of Russian Economy Digitalization (illustrated by oil industry)
Authors: Sorokin N. S. , Khatiushin D. I.
Published: September 2023

The article analyzes the use of digitalization in oil industry on today’s stage of development and studies best practices of such companies as ‘Lukoil’ and ‘Gaspromneft’. Findings of the research showed barriers for introducing digital technologies in oil industry, i. e. a shortage of highly-qualified workers, who could work with robotized production processes, the necessity to invest large finance resources and difficulties in realizing import-substitution technologies. At the same time two key trends aimed at these challenges minimization were put forward: the development of digital strategy of the company and setting-up own digital techno-parks. Principle advantages of industry digitalization were shown: possibility to attract investors, to increase volumes of mineral resource extraction, to grow the number of spheres of oil companies’ work and to cut costs on equipment maintenance.
EVALUATING PUBLIC COMPLIANCE WITH WILDLIFE CONSERVATION LAW IN WUHAN, CHINA
Authors: Sharaai Amir Hamzah , Yujing Zha , Wafa Wafaurahman , Sining Ma , Zhijian He
Published: September 2023

As a result of the outbreak of COVID-19 in mainland China, the governments expedite the legislation of the Wildlife Protection Law (WPL) by proposing a comprehensive prohibition on wildlife eating and trading in the latest WPL due to the potential association between the outbreak and wildlife. However, the prohibition could affect the current social-economic system, leading to a void of legislation due to the disobedience of laws in society. Public readiness toward the law has a strong relationship with expected obedience to it. Therefore, the objectives of this study are to assess the two components of the readiness knowledge about the law and the readiness toward the actions potentially contradicting the latest WPL. Another objective is to collect participants' opinions and reasons on whether they think the latest WPL is difficult to enforce. By selecting the epicenter Wuhan as a study site, voluntary response sampling was used to distribute the questionnaire online. The data obtained from 410 respondents show that the citizens in Wuhan have average knowledge about the latest WPL but are unaware of the definition of wildlife. Based on the Mann-Whitney test, the study found no significance between gender and knowledge, but it exists in all other comparisons. Moreover, the significance only exists between readiness scale and age groups. The difficulty in enforcing the latest WPL underlines the problems in enforcement, awareness, demand, and society aspect, while on the opposite, respondents highlight the lesson from the pandemic and belief in the governments. In conclusion, citizens in Wuhan show a medium readiness toward the latest WPL, which is vital to design optimal legislation.
PERCEPTUAL DIFFERENCES OF TREE REMOVAL IN DEVELOPMENT AREAS AMONG LANDSCAPE PROFESSIONALS
Authors: Hassan Khalilah , Wan Mohamad Wan Saiful Nizam , Hasan Ramly , Md Alwi Najah
Published: September 2023

Urban areas employ proactive strategies to effectively manage their urban tree population, aiming to enhance the overall coverage of tree canopies. This process involves certified landscape practitioners (ALP) and individuals without formal professional credentials (LP) who collectively contribute to decision-making processes. However, there is limited information on the perception among these LPs. Thus, this study employed a questionnaire survey to obtain empirical observations from the perceptions of landscape professionals in both groups about tree removal by comparing similarities and differences and identifying the factors influencing existing tree removal decisions in development areas. The study used simple random sampling involving 265 respondents, 102 ALPs and 163 LPs. Descriptive and exploratory factor analysis (EFA) were used to analyse the data. Results showed that the tree removal was a common decision in urban development. Both groups of respondents agreed on three factors influencing tree removal in development areas: institutional constraints, resource availability, and cost/benefit, with institutional constraints being the primary determinant of the decision-making process. Additionally, ALPs posited that the physical environment influences tree removal decision-making. On the other hand, The LPs contended that this decision was also motivated by preferences and tree characteristics. This research advances urban tree retention literature and provides pertinent information for tree retention and management planning and strategy. Future studies may consider investigating the perceptions of different landscape professional credentials related to site design and construction to strengthen the research findings.