bluuebunny/crossref_metadata_2025 huggingface dataset:
A comparison of assays for the detection of Cryptosporidium parvum in the feces of scouring calves
Authors: Atwal Harveen K. , Zabek Erin , Bidulka Julie , DuCharme Alecia , Pawlik Michael , Himsworth Chelsea G.
Published: January 2022

Cryptosporidium parvum is a zoonotic, protozoan parasite that causes potentially life-threatening diarrhea in the host and can be transmitted via the fecal-oral route. C. parvum can infect cattle and may be detected in their feces using a variety of tests. We compared the level of agreement, ease of procedure, and cost among PCR, lateral flow immunoassay, fluorescent antibody, and Kinyoun acid-fast stain direct smear tests. Over the course of 9 mo, 74 calf fecal samples were submitted and tested for C. parvum using all 4 tests. A Fleiss kappa value of 0.813 was obtained, indicating an excellent level of agreement among tests. Overall, the best test based on cost and ease of procedure was the Kinyoun acid-fast stain direct smear.
Conceptualizing a Quantitative Measurement Suite to Evaluate Healthcare Teams
Authors: Paige John T. , Rogers Camille L. , Kerdolff Kathryn E. , Garbee Deborah D. , Bonanno Laura S. , Yu Qingzhao
Published: January 2022

Background

Current team assessment instruments in healthcare tend to involve rater-based evaluations that are susceptible to well-known biases. Recent advances in technology include portable devices to measure team-based activities. Consequently, the possibility exists to move away from rater-based assessments of team function by identifying quantitative measures to replace them.

Aim

This article aims to provide potential approaches to developing quantitative measurement suites involving large amounts of data to address the challenges of assessment presented by the complex nature of teamwork.

Conclusion

By addressing construct, measurement, and context components, we provide a practical approach to developing a suite to capture quantitative measurements that, through incorporation of social network analysis and aggregated other values, aligns with the Team Strategies & Tools to Enhance Performance and Patient SafetyTM (TeamSTEPPSTM) dimensions for fostering teamwork.
Facial Nerve Dysfunction After Mandibular Distraction Osteogenesis in Patients with Robin Sequence: A Systematic Review and Meta-Analysis
Authors: Kapoor Elina , Mantilla-Rivas Esperanza , Rana Md Sohel , Aivaz Marudeen , Duarte-Bateman Daniela , Escandón Joseph M. , Crowder Hannah R. , Manrique Monica , Rogers Gary F. , Oh Albert K.
Published: January 2022

Objective

Robin Sequence (RS), characterized by micrognathia, glossoptosis, and upper airway obstruction, is an increasingly recognized diagnosis. An effective surgical intervention is mandibular distraction osteogenesis (MDO). This study analyzes published evidence regarding facial nerve dysfunction (FND) associated with MDO.

Design and Setting

According to PRISMA guidelines, a systematic review was carried out with databases queried in June 2019 using MESH terms, or equivalent terms, as follows: “distraction osteogenesis” and “Robin Sequence”. A review of original Spanish and English articles, were included. Outcome measures included the prevalence of FND; the affected branches; the rate of permanent vs. transient FND; the use of an internal vs. external device; the daily distraction rate; and finally, the overall distraction length. Subsequently, a meta-analysis was conducted to collate results regarding the prevalence of FND and the factors associated with it.

Results

Of 239 unique studies identified, 19 studies with 729 patients met inclusion criteria; 52 patients developed FND after MDO. A random-effects meta-analysis yielded a pooled prevalence of FND of 6.40%, with moderately heterogeneous studies (I2 = 41%, τ2 = 0.006). Marginal mandibular nerve involvement was most commonly noted. Nine studies reported transient FND, six permanent, one both, and two unspecified. Internal distractors were used in 8 studies and external in 3 and both in 2. Distraction rate was 1.00 to 2.00 mm/day and total distraction length ranged from 13.00 to 22.3 mm. Sample size was the only parameter inversely associated with rate of FND (p = 0.04).

Conclusion

This analysis of FND associated with MDO for patients with RS demonstrates a lack of consistent documentation. MDO-associated FND does not appear to be uncommon, and permanent dysfunction can occur. This review underscores the importance of thorough documentation to elucidate the mechanism of FND.
Upper limb involuntary tremor reduction using cantilever beam TMDs
Authors: Gebai Sarah , Cumunel Gwendal , Hammoud Mohammad , Foret Gilles , Roze Emmanuel , Hainque Elodie
Published: January 2022

Tuned mass dampers (TMDs) are proposed as a solution to reduce the involuntary tremor at the upper limb of a patient with postural tremor. The upper limb is modeled as a three-degrees-of-freedom rotating system in the vertical plane, with a flexion-extension motion at the joints. The measured extensor carpi radialis signal of a patient is used to excite the dynamic model. We propose a numerical methodology to optimize the parameters of the TMDs in the frequency domain combined with the response in the time domain. The objective function for the optimization of the dynamic problem is the maximum angular displacement of the wrist joint. The optimal stiffness and damping of the TMDs are obtained by satisfying the minimization of the selected objective function. The considered passive absorber is a cantilever beam–like TMD, whose length, beam cross-sectional diameter, and mass position reflect its stiffness for a chosen additional mass. A parametric study of the TMD is conducted to evaluate the effect of the TMD position along the hand segment, the number of TMDs, and the total mass of TMDs. The sensitivity of the TMD to a decrease of its modal damping ratio is studied to meet the range of stainless steel. TMDs are manufactured using stainless steel beams of the same length (9.1 cm) and cross-sectional diameter (0.79 mm), for which the mass (14.13 g) position is adjusted to match the optimal frequency. Three TMDs holding a mass of 14.13 g each cause 89% reduction in the wrist joint angular displacement.
Orthonormal piecewise Bernoulli functions: Application for optimal control problems generated using fractional integro-differential equations
Authors: Heydari Mohammad Hossein , Razzaghi Mohsen , Avazzadeh Zakieh
Published: January 2022

In this study, the orthonormal piecewise Bernoulli functions are generated as a new kind of basis functions. An explicit matrix related to fractional integration of these functions is obtained. An efficient direct method is developed to solve a novel set of optimal control problems defined using a fractional integro-differential equation. The presented technique is based on the expressed basis functions and their fractional integral matrix together with the Gauss–Legendre integration method and the Lagrange multipliers algorithm. This approach converts the original problem into a mathematical programming one. Three examples are investigated numerically to verify the capability and reliability of the approach.
Charles Bonnet syndrome as first manifestation of occipital infarction
Authors: Martínez-Sánchez Marta Isabel , Bolívar Gema
Published: January 2022

Purpose

To describe a case of Charles Bonnet syndrome as the first manifestation of occipital infarction in a patient with preserved visual acuity.

Observations

We report a 78-year-old man followed in our department with a two-month-long history of visual hallucinations based on the vision of flowers and fruits intermittently, being perceived as unreal images. Best-corrected visual acuity was stable in the follow-up time being 20/20 in the right eye and 20/25 in the left eye. Extraocular muscle function testing, pupillary reflexes, biomicroscopy, fundus and optical coherence tomography examinations did not reveal any interesting findings. In order to rule out occipital pathology, orbital-cerebral magnetic resonance imaging was performed, showing an image compatible with the chronic ischemic right occipital lesion. The patient was diagnosed with Charles Bonnet syndrome secondary to occipital infarction and neurology decided that no treatment was required. 24-2 and 10-2 visual field tests showed no remarkable alterations and Full-field 120 point screening test showed nonspecific peripheral defects. Hallucinations improved over the months, being described as not annoying and increasingly infrequent.

Conclusions and Importance

Charles Bonnet syndrome is a condition characterized by the presence of recurrent and complex visual hallucinations in patients with visual pathway pathologic defects. Visual acuity or visual field loss is not a requirement for diagnosis. Charles Bonnet syndrome should be suspected in all patients with non-disturbing visual hallucinations, even though they present good visual acuteness. It will be essential to perform complementary explorations to identify the underlying pathology that allows the starting of a correct treatment option.
Long-term outcomes in Primary congenital glaucoma, aniridia and anterior segment dysgenesis
Authors: Magan Tejal , Tanner Alexander , Fajardo-Sanchez Julia , Lim Kin Sheng , Goyal Saurabh , Rodrigues Ian , Amaya Luis , Trikha Sameer , Kulkarni Avinash , Hammond Christopher , Lascaratos Gerassimos , Yu-Wai-Man Cynthia
Published: January 2022

Aim

To determine the long-term outcomes of a cohort of complex patients with primary congenital glaucoma, aniridia and anterior segment dysgenesis.

Methods

Retrospective consecutive series between 1990–2021 in two UK tertiary centres: Guy's and St Thomas’ NHS Foundation Trust and King's College Hospital NHS Foundation Trust. We recorded the number and types of surgical and laser treatments along with preoperative and postoperative data, including intraocular pressures (IOP) and anti-glaucoma medications.

Results

A total of 41 eyes of 21 patients were included. Primary diagnoses were primary congenital glaucoma in 16 eyes (39.0%), aniridia in 14 eyes (34.2%), and anterior segment dysgenesis in 8 eyes (19.5%). Sixteen eyes (39.0%) had one or more glaucoma surgery or laser procedures for advanced glaucoma, and the long-term follow-up was 12.8 ± 3.6 years. There was a significant decrease in postoperative IOP (mmHg) at 3 months (16.5 ± 1.6; p = 0.0067), 6 months (18.7 ± 2.1; p = 0.0386), 12 months (18.6 ± 1.7; p = 0.0229), 3 years (14.7 ± 1.2; p = 0.0126), 5 years (15.5 ± 1.8; p = 0.0330) and 10 years (15.4 ± 2.3; p = 0.7780), compared to preoperatively (24.1 ± 2.6). Surgical success (complete and qualified) was 62.5%, 50.0%, 43.8%, 46.2%, 45.5% and 28.6% at 3 months, 6 months, 12 months, 3 years, 5 years and 10 years, respectively. There was no significant change in the number of anti-glaucoma drugs postoperatively ( p > 0.05). Four eyes (25.0%) had postoperative complications (hyphaema, hypotony) that resolved after conservative management.

Conclusions

Surgical management of these complex eyes with advanced glaucoma is challenging. Overall, the cohort had good surgical outcomes with a significant decrease in IOP by 36.1% after long-term follow-up.
Focal choroidal excavation associated with nonmelanocytic iris tumor
Authors: Montesel Andrea , Eandi Chiara M. , Zografos Leonidas
Published: January 2022

Purpose

To describe a unique unilateral association between an iris stromal tumor and a macular focal choroidal excavation.

Case Description

A 40-year old patient presented with a small iris tumor associated with a unilateral macular lesion disclosed during a routine ophthalmologic examination. The patient was asymptomatic and visual function was not affected. After clinical and instrumental evaluation, a diagnosis of nonmelanocytic undefined stromal tumor of the iris associated with macular focal choroidal excavation was made. The size and shape of the two lesions remained stable during a 7-year follow-up and the patient did not develop other signs.

Conclusion

The concurrent presence of a stromal iris tumor associated with focal choroidal excavation has never been reported. Further reports of this association are required in order to understand its exact pathogenesis.
Internal jugular to internal jugular vein bypass of symptomatic central vein obstruction
Authors: Carleton Jared , Chang Jason , (Richard) Pu Qinghua , Rhee Robert
Published: January 2022

Introduction:

Central venous obstruction (CVO) often arises among hemodialysis patients with upper extremity access due to a varying number of risk factors. While the true incidence of CVO in hemodialysis patients is unknown, it been reported in the range of 20%–40% in dialysis patients undergoing venograms. In the non-hemodialysis population, chronic central vein obstruction has a compensatory mechanism comprised of numerous collaterals along the chest wall, neck, and mediastinum. However, the presence of an AVF or AVG ipsilateral to a central venous stenosis or occlusion can overwhelm the collateral network due to the significantly elevated blood flow. This may result in severe and debilitating upper extremity and fascial swelling. While ligation results in almost instantaneous symptomatic relief, it does not address the patient’s underlying pathologic process and necessitates an additional access. As these patients continue to live longer, our strategies to manage these failing accesses are becoming increasingly complex. The goal of preserving existing access while correcting any symptoms is paramount. Previous case reports have documented various surgical options for preserving an existing access.

Case presentation:

Our patient is a 49-year-old female with hypertension and end-stage renal disease, on hemodialysis through a right arm arteriovenous (AV) fistula. She had a history of multiple AV fistulae creations in the past, all of which previously thrombosed. Several years after the creation of her most recent fistula, she developed severe throbbing headaches, right arm and facial swelling, right eye lacrimation, and blurry vision. AV fistula angiogram demonstrated right brachiocephalic vein chronic occlusion and endovascular revascularization through both trans-AVF and transfemoral approaches were attempted, but unsuccessful.

Discussion:

This case illustrates the success of the creation of an internal jugular-jugular vein bypass to maintain a right arm arteriovenous fistula, while at the same time, correcting the symptoms of a right brachiocephalic vein occlusion.
The Persistence of the Victorian Prison: Alteration, Inhabitation, Obsolescence, and Affirmative Design
Authors: Moran Dominique , Houlbrook Matt , Jewkes Yvonne
Published: January 2022

Prior scholarship tracing the origins and architecture of prisons has tended to focus on how and why prisons are built—what they are intended to achieve and their construction as an expression of the punitive philosophies of their age. It does not consider how prisons persist as time passes, perhaps beyond their anticipated operational life span, and into “obsolescence.” Focusing on the archetypal Victorian prison, and considering the alteration and inhabitation of such prisons through time, this article critically reinterprets notions of obsolescence in the built environment and explores an enduring cultural attachment to a particular and arguably archaic material manifestation of punishment.
Exploring user agency and small acts of algorithm engagement in everyday media use
Authors: Kapsch Patrick Heiberg
Published: January 2022

Based on participant-driven media use tracking and self-reflexive media use Vlogs, this article explores how young adult media users make sense of their user agency vis-à-vis algorithms in digital media and how they try actualizing it through reflexive and mundane enactments of algorithmic systems. The article proposes to adapt the concept of ‘small acts of engagement’ to grasp the productive and agentic potentials of how users enact algorithms purposively in daily media use. By engaging research participants actively in reflections to better understand, and possibly respond to the influence of algorithmic power in daily media use, the study unfolds common boundaries of users’ reflexive capabilities, showing how exercising user agency in a datafied age is increasingly complex and prospective, yet not merely limited by algorithmic power. As a result, the article discusses the methodological implications and potentials of engaging media users in reflections and actions to shape their communicative agency, which might be a possible step towards mobilizing algorithmic literacy.
Fault diagnosis systems for rotating machines operating with fluid-film bearings
Authors: Stebakov Ivan , Kornaev Alexey , Popov Sergey , Savin Leonid
Published: January 2022

The paper deals with the application of deep learning methods to rotating machines fault diagnosis. The main challenge is to design a fault diagnosis system connected with multisensory measurement system that will be sensitive and accurate enough in detecting weak changes in rotating machines. The experimental part of the research presents the test rig and results of high-speed multisensory measurements. Six states of a rotating machine, including a normal one and five states with loosened mounting bolts and small unbalancing of the shaft, are under study. The application of deep network architectures including multilayer perceptron, convolutional neural networks, residual networks, autoencoders and their combination was estimated. The deep learning methods allowed to identify the most informative sensors, then solve the anomaly detection and the multiclass classification problems. An autoencoder based on ResNet architecture demonstrated the best result in anomaly detection. The accuracy of the proposed network is up to 100% while the accuracy of an expert is up to 65%. A one-dimensional convolutional neural network combined with a multilayer perceptron that contains a pretrained encoder demonstrated the best result in multiclass classification. The detailed fault detection accuracy with the determination of the specific fault is 83.3%. The combinations of known deep network architectures and application of the proposed approach of pretraining of the encoders together with using a block of inputs for one prediction demonstrated high efficiency.
An exception to every rule; high velocity impact not always required for bilateral 1st rib fractures
Authors: Kutywayo Kudzayi H , Thekkudan Joyce , Tyson Nathan , Chowdhry Mohammed F
Published: January 2022

Introduction

First rib fractures are commonly reported in high velocity trauma. The neuromuscular sequelae that can ensue, not the physical disruption of the rib, necessitate thorough evaluation for such injuries.

Methods

We describe a case of a patient who sustained bilateral rib fractures following low-energy trauma.
Joining sheets made from dissimilar materials by hole hemming
Authors: Kasaei Mohammad Mehdi , da Silva Lucas FM
Published: January 2022

This research work presents a new joining process based on the hemming process for attaching sheets made from dissimilar materials with very different mechanical properties. The process is termed ‘hole hemming’ and consists in producing a mechanical interlock between pre-drilled holes which can be made anywhere on the sheets. The process is carried out in a two-stage operation including flanging the hole of an outer sheet and bending the flange over the hole of an inner sheet. First, the joining stages and the required tools are designed. Then, the joining of DP780 steel and AA6061-T6 aluminium alloy sheets, which are applied to manufacture lightweight structures in the automotive industries, is investigated using finite element analysis. Results show that the hole hemming process is able to successfully join these materials without fracture. The hole-hemmed joint withstood the maximum forces of 2.5 and 0.5 kN in single-lap shear and peel tests, respectively, and failed with hole bearing mode which is known as a gradual failure mode. The results demonstrate the applicability of the hole hemming process for joining dissimilar materials.
Trust and temporality in participatory research
Authors: Armstrong Andrea , Flynn Emma , Salt Karen , Briggs Jo , Clarke Rachel , Vines John , MacDonald Alistair
Published: January 2022

This paper argues that trust cannot be taken for granted in long-term participatory research and promotes greater consideration to conceptualizing the trusting process as fluid and fragile. This awareness by researchers can reveal to them how the passing of time shapes and reshapes the nature of trusting relationships and their constant negotiation and re-negotiation. The paper draws together literature from different disciplines on the themes of trust, temporality and participatory research and outcomes from interviews and workshops undertaken for The Trust Map project to focus on two key moments that reveal the fragility of trust. These are the subtlety of disruption and trust on trial and trust at a distance. We discuss how trust was built over time through processes of interaction that were continually tested, incremental and participatory.
Are knowledgeable voters better voters?
Authors: Hannon Michael
Published: January 2022

It is widely believed that democracies require knowledgeable citizens to function well. But the most politically knowledgeable individuals tend to be the most partisan and the strength of partisan identity tends to corrupt political thinking. This creates a conundrum. On the one hand, an informed citizenry is allegedly necessary for a democracy to flourish. On the other hand, the most knowledgeable and passionate voters are also the most likely to think in corrupted, biased ways. What to do? This paper examines this tension and draws out several lessons. First, it is not obvious that more knowledgeable voters will make better political decisions. Second, attempts to remedy voter ignorance are problematic because partisans tend to become more polarized when they acquire more information. Third, solutions to citizen incompetence must focus on the intellectual virtue of objectivity. Fourth, some forms of epistocracy are troubling, in part, because they would increase the political power of the most dogmatic and biased individuals. Fifth, a highly restrictive form of epistocracy may escape the problem of political dogmatism, but epistocrats may face a steeper tradeoff between inclusivity and epistemic virtue than they would like.
Study on the application of BP neural network optimized based on various optimization algorithms in storm surge prediction
Authors: Zhang Xiao-qi , Jiang Si-qi
Published: January 2022

Storm surge prediction is of great importance to disaster prevention and mitigation. In this study, four optimization algorithms including genetic algorithm (GA), particle swarm optimization (PSO), beetle antenna search (BAS), and beetle swarm optimization (BSO) are used to optimize the back propagation neural network (BPNN), and four optimized BPNNs for storm surge prediction are proposed and applied to Yulin station and Xiuying station at Hainan, China. The optimal model parameter combination is determined by trail-and-error method for the best prediction performance. Comparisons with the single BPNN indicate that storm surge can be efficiently predicted using the optimized BPNNs. BPNN optimized by BSO has the minimum prediction error, and BPNN optimized by BAS has the minimum time cost to reduce unit prediction error.
Diagnosis of internal cracks in concrete using vibro-acoustic modulation and machine learning
Authors: Miele Sarah , Karve Pranav M , Mahadevan Sankaran , Agarwal Vivek
Published: January 2022

This paper investigates the utility of physics-informed machine learning models for vibro-acoustic modulation (VAM)–based damage localization in concrete structures. Vibro-acoustic modulation is a nonlinear dynamics-based non-destructive testing method, which was initially developed to perform damage detection and later extended to accomplish damage localization. The VAM-based damage (hidden crack) diagnosis is performed by analyzing the damage index pattern on the surface of the component to arrive at the size and location of the hidden damage. Past investigations have employed heuristically selected damage index thresholds as well as computationally expensive Bayesian estimation methods for VAM-based damage localization in two (surface) dimensions. Compared to these studies, the proposed methodology automates the threshold selection (algorithmic instead of heuristic), increases the speed of the probabilistic damage diagnosis process, and enables the estimation of damage depth. We generate training data (damage index) for the machine learning models using the pertinent nonlinear dynamics (finite element) models using different combinations of test parameters. The (supervised) machine learning models are thus informed by computational physics models. These include two types of artificial neural network (ANN) models: classification models that identify whether a sensor location is damaged or not and regression models that enable Bayesian estimation to obtain the posterior probability distribution of damage location and size. The accuracy of machine learning-based diagnosis is evaluated using both numerical and laboratory experiments. The proposed physics-informed machine learning models for VAM-based damage diagnosis are able to achieve an accuracy of about 60–64% in the validation experiments, indicating the potential of these methods for internal crack detection. The results show that for complex (nonlinear dynamics-driven) diagnostic methods, damage index patterns learned from physics models could be successfully used for damage detection as well as localization.
Retrograde Recanalization of Occluded Radial Artery: A Single-Centre Experience and Literature Review
Authors: Shi Ganwei , Li Feng , Zhang Liuyan , Gong Chun , Xue Sheliang , Song Yanbin , Cai Gaojun
Published: January 2022

Purpose:

Radial artery occlusion (RAO) is one of the common complications after coronary intervention via the conventional radial artery approach. The purpose of the study was to explore the safety and feasibility of retrograde recanalization of the occluded radial artery via a distal radial artery (DRA) approach.

Methods:

Combined with the practice of our centre and a literature review, we summarized the procedure of retrograde recanalization of RAO, success rate, and complications.

Results:

A total of 14 of 15 patients with 15 pieces of occluded radial arteries were successfully recanalized via the DRA in our centre. In the 15 occluded vessels, 11 vessels (73.3%) had total occlusion and 4 vessels (26.7%) had functional occlusion. Four of 15 occluded vessels were acute occlusions. Two acute RAOs were only treated with aspiration via sheath, 11 RAOs with balloon angioplasty, and 2 RAOs with both, respectively. In 6 patients, cardiac catheterization was carried out via the DRA after recanalizing the RAO. A total of 10 studies reporting the results of recanalization of RAO via the DRA were systematically retrieved in the present study. In 3 case series, the number of cases was more than 5, and the success rate of recanalization was more than 85.7%. Two studies reported complications, including dissection in one case, hematoma in 2 cases, and pain in the forearm during angioplasty.

Conclusions:

Recanalization of the occluded radial artery via the DRA was safe and effective. When repeat cardiac catheterization was required, recanalization of the RAO and subsequent coronary angiography or intervention through the ipsilateral radial artery approach was feasible.
Acute isolated posterior cerebral artery stroke treated with mechanical thrombectomy: A single-center experience and review of the literature
Authors: Baig Ammad A , Monteiro Andre , Waqas Muhammad , Cappuzzo Justin M , Siddiqi Manhal , Doane Jacob , Dossani Rimal H , Almayman Faisal , Khawar Wasiq I , Davies Jason M , Snyder Kenneth V , Levy Elad I , Siddiqui Adnan H
Published: January 2022

Background

Acute isolated posterior cerebral artery (PCA) occlusions account for 5–10% of all ischemic events. Due to peculiar patient presentation, the potential benefit of mechanical thrombectomy (MT) remains controversial. We evaluated the safety, feasibility, and effectiveness of MT in our patients and compared our results with the literature review conducted.

Methods

Charts were reviewed retrospectively for consecutive patients diagnosed with acute PCA stroke who underwent MT. Demographics, procedural, and follow-up details were noted. For the literature review, a systematic search of PubMed, MEDLINE, and EMBASE databases was conducted for the keywords “posterior cerebral artery” and “thrombectomy” for articles published between January 1, 2010 and June 30, 2021. Estimated rates for recanalization, favorable outcomes (modified Rankin Scale [mRS] score 0–2), symptomatic intracerebral hemorrhage (sICH), and mortality were extracted.

Results

Our cohort included 21 patients. Mean age was 71.2 years (standard deviation [SD] ± 10.2). Median National Institutes of Health Stroke Scale (NIHSS) presentation score was 9 (interquartile range [IQR] 5–15), with visual symptoms reported in 12(57.1%) patients. Overall, final modified thrombolysis in cerebral infarction (mTICI) 2b-3 was achieved in 17 patients (80.9%) with first-pass mTICI 2b-3 attained in 8 (38.1%). Postprocedure sICH occurred in 1 (4.8%) patient. Fifteen (71.4%) patients had a 0–2 mRS score at 90 days. Visual symptoms resolved in 10 of 12(83.3%) patients. Mortality occurred in 2 (9.5%) patients. For the systematic review, cohorts from 4 articles plus ours were included, totaling 222 patients. The estimated rate of successful recanalization was 85.25% (95% confidence interval[CI], 73.05%–97.45%), sICH was 3.60% (95% CI, 1.11%–6.09%), and mortality was 10.51% (95% CI, 5.88%–15.15%).

Conclusion

The results of our series and systematic review indicate MT as a potentially safe and effective treatment modality for acute PCA stroke. These results also indicate that patient selection and assessment may be the key in obtaining favorable outcomes.
Small-sided games do not replicate all external and internal loads of a football match-play during pre-season: A case study
Authors: Pinheiro Guilherme de Sousa , Chiari Quintão Roberto , Nascimento Vitor Bertoli , Claudino João Gustavo , Alves Adriano Lima , Teoldo da Costa Israrel , Teoldo da Costa Varley
Published: January 2022

This study investigated the differences in external and internal load during pre-season training sessions carried out with different SSGs and a friendly match in top-class professional football players. The study was conducted over a full pre-season. Participants were 9 male top-class professional football players (25 ± 5 years; 74 ± 8 kg; 177 ± 8 cm). The following variables were measured: training session duration (min), average heart rate (bpm), total distance (m), distance covered per minute (m/min), the total number of accelerations > 2.5 m/s2, number of accelerations > 2.5 m/s2 per minute, average distance of accelerations (m), the average value of acceleration (m/s2). One-way ANOVA was performed to analyze the variance of all evaluated variables. No differences were found in the average accelerations (m/s2) (0.128) among all the training formats. Moderate differences were found in number of accelerations > 2.5 m/s2 per minute (η2 = 0.396, moderate effect) and average distance of accelerations (η2 = 0.545). Strong differences were found in HR (η2 = 0.788, large effect), total distance (η2 = 0.797, strong effect), distance per minute (η2 = 0.775 strong effect), total number of accelerations > 2.5 m/s2 (η2 = 0.699 strong effect). Significant correlations were found just for the number of accelerations > 2.5 m/s2 and the number of accelerations > 2.5 m/s2 per minute with the 4v4, 8v8 and the FM (r = 0.828–0.890, r2 = 69% – 79%; p < 0.01). External and internal loads differ across different SSGs and a FM during the pre-season training sessions.
Identifying candidates for immunotherapy with cemiplimab to treat advanced cutaneous squamous cell carcinoma: an expert opinion
Authors: Argenziano Giuseppe , Fargnoli Maria Concetta , Fantini Fabrizio , Gattoni Massimo , Gualdi Giulio , Pastore Francesco , Pellacani Giovanni , Quaglino Pietro , Queirolo Paola , Troiani Teresa
Published: January 2022

Cutaneous squamous cell carcinoma (CSCC) is the second most common skin malignancy in white-skinned populations. Only a minority of patients (<5%) develop advanced disease, but this is often difficult to treat and characterised by a poor prognosis. Cemiplimab, a fully human IgG4 monoclonal antibody against programmed cell death-1 receptor, is indicated for advanced (i.e. locally advanced or metastatic) CSCC. Although the definition of metastatic CSCC is clear, there is currently no agreed definition of locally advanced CSCC. In recent guidelines, locally advanced CSCC was described as non-metastatic CSCC that is unlikely to be cured with surgery, radiotherapy or combination treatment. A multi-disciplinary advisory group of Italian CSCC experts was convened to develop criteria to assist in identifying appropriate candidates for cemiplimab therapy in advanced CSCC, based on the literature and clinical experience. In locally advanced CSCC, absolute, or mandatory, criteria for the use of cemiplimab are deep invasion, multiple lesions without defined margins, inadequate surgical excision margins and multiple recurrences, whereas relative criteria include large lesions, in critical or functionally significant areas and that are surgically complex. In addition, physicians should consider patient willingness/preferences (an absolute criterion), and their age and health status/comorbidities (relative criteria). It is hoped that these proposed absolute and relative criteria will help guide rational identification of patients who will receive maximum benefit from immunotherapy, while more clinical data accumulate.
Serum NfL levels in the first five years predict 10-year thalamic fraction in patients with MS
Authors: Lokhande Hrishikesh , Rosso Mattia , Tauhid Shahamat , Chu Renxin , Healy Brian C. , Saxena Shrishti , Barro Christian , Paul Anu , Polgar-Turcsanyi Mariann , Anderson Mark , Glanz Bonnie I. , Kropshofer Harald , Granziera Cristina , Leppert David , Kappos Ludwig , Kuhle Jens , Weiner Howard L. , Bakshi Rohit , Chitnis Tanuja
Published: January 2022

Background

Serum neurofilament light chain (sNfL) levels are associated with relapses, MRI lesions, and brain volume in multiple sclerosis (MS).

Objective

To explore the value of early serum neurofilament light (sNfL) measures in prognosticating 10-year regional brain volumes in MS.

Methods

Patients with MS enrolled in the Comprehensive Longitudinal Investigations in MS at Brigham and Women's Hospital (CLIMB) study within five years of disease onset who had annual blood samples from years 1–10 (n = 91) were studied. sNfL was measured with a single molecule array (SIMOA) assay. We quantified global cortical thickness and normalized deep gray matter (DGM) volumes (fractions of the thalamus, caudate, putamen, and globus pallidus) from high-resolution 3 T MRI at 10 years. Correlations between yearly sNfL levels and 10-year MRI outcomes were assessed using linear regression models.

Results

sNfL levels from years 1 and 2 were associated with 10-year thalamus fraction. Early sNfL levels were not associated with 10-year putamen, globus pallidus or caudate fractions. At 10 years, cortical thickness was not associated with early sNfL levels, but was weakly correlated with total DGM fraction.

Conclusions

Early sNfL levels correlate with 10-year thalamic volume, supporting its role as a prognostic biomarker in MS.
Corruption – Poverty Nexus: Evidence from Panel ARDL Approach for SAARC Countries
Authors: Vinayagathasan Thanabalasingam , Ramesh Ramasamy
Published: January 2022

The article intends to investigate the relationship between corruption and poverty based on the panel data of SAARC countries over the period 1996–2019. We employed the panel ARDL of pooled mean group (PMG) technique to analyze the data and focus on capability poverty, using the human development index (HDI) as a proxy for poverty. The empirical findings of PMG of the ARDL model suggest that an increase in corruption score (COC) (i.e. decrease in corruption) and increase in women’s labor force participation rate (WLFPR) seem to have a significant impact either in eradicating poverty or increasing social welfare in the long run as well as in the short run. A random effect (RE) model also identified a significant positive relationship between corruption score and HDI, and WLFPR and HDI. A Dumitrescu-Hurlin pairwise panel Granger non-causality test detected a bilateral causality relationship between COC and HDI, and WLFPR and HDI, while unilateral causality ran from WLFPR to COC. The article contributes to examining the dynamics between corruption and poverty from the governance aspect, taking South Asia as a case study.
The Hierarchical Taxonomy of Psychopathology (HiTOP) Is Not an Improvement Over the DSM
Authors: Haeffel Gerald J. , Jeronimus Bertus F. , Fisher Aaron J. , Kaiser Bonnie N. , Weaver Lesley Jo , Vargas Ivan , Goodson Jason T. , Soyster Peter D. , Lu Wei
Published: January 2022

In their response to our article (both in this issue), DeYoung and colleagues did not sufficiently address three fundamental flaws with the Hierarchical Taxonomy of Psychopathology (HiTOP). First, HiTOP was created using a simple-structure factor-analytic approach, which does not adequately represent the dimensional space of the symptoms of psychopathology. Consequently, HiTOP is not the empirical structure of psychopathology. Second, factor analysis and dimensional ratings do not fix the problems inherent to descriptive (folk) classification; self-reported symptoms are still the basis on which clinical judgments about people are made. Finally, HiTOP is not ready to use in real-world clinical settings. There is currently no empirical evidence demonstrating that clinicians who use HiTOP have better clinical outcomes than those who use the Diagnostic and Statistical Manual of Mental Disorders ( DSM). In sum, HiTOP is a factor-analytic variation of the DSM that does not get the field closer to a more valid and useful taxonomy.
Painful catamenial vulvar lesions misleading gynecologist
Authors: Yildiz Sule , Bilir Esra , Yilmaz Dikmen Bahar , Bulutay Pınar , Turkgeldi Engin , Ata Baris
Published: January 2022

Endometriosis usually presents as cyclical pain in the pelvis but may also present as painful cutaneous lesions. Many diseases may mimic hidradenitis suppurativa (HS) since HS, a chronic inflammatory painful skin disease, is a clinical diagnosis. A 32-year-old woman presented with painful lumps on her vulva and groin accompanied with bloody discharge during menstruation. She was followed up with preliminary diagnosis of endometriosis. Previous excision without definitive diagnosis resulted in temporary relief. She was prescribed oral contraceptive pills that alleviated her symptoms but quitted due to headache. Surgical excision was performed for definitive diagnosis and therapeutic relief. Pathology report revealed HS. She was prescribed oral doxycycline. She responded well to the therapy and has symptom-free for the last 2 years. She delivered one healthy girl via cesarian section 2 years after the treatment. Endometriosis and HS should be included in the differential diagnosis when women present with menstrual painful lesions around external genitalia for diagnosis and treatment.
A Primary Care Intervention to Increase HIV Pre-Exposure Prophylaxis (PrEP) Uptake in Patients with Syphilis
Authors: Bonner Ryan , Stewart Jessica , Upadhyay Ashish , Bruce R. Douglas , Taylor Jessica L.
Published: January 2022

Identifying candidates for HIV pre-exposure prophylaxis (PrEP) is a barrier to improving PrEP uptake in priority populations. Syphilis infection is an indication for PrEP in all individuals and can be easily assessed by primary care providers (PCP) and health systems. This retrospective study evaluated the impact of a multidisciplinary provider outreach intervention on PrEP uptake in patients with a positive syphilis test result in a safety-net hospital-based primary care practice. The PCPs of PrEP-eligible patients with a positive syphilis result were notified via the electronic medical record (EMR) about potential PrEP eligibility and institutional HIV PrEP resources. Rates of PrEP offers and prescriptions were compared in the pre (8/1/2018-12/31/2018, n = 60) and post (1/1/2019-5/31/2019, n = 86) intervention periods. Secondary analyzes evaluated receipt of appropriate syphilis treatment and contemporaneous screening for HIV, gonorrhea, and chlamydia. No significant differences in the overall proportion of patients offered (15% vs 19%) and prescribed (7% vs 5%) PrEP were observed between the pre- and post-periods. Overall, 7% of positive tests represented infectious syphilis. The rate of appropriate syphilis treatment was equivalent (57% vs 56%) and contemporaneous screening for other sexually transmitted infections was suboptimal across the entire study period. Although any positive syphilis test may be an easily abstracted metric from the EMR, this approach was inclusive of many patients without current HIV risk and did not increase PrEP uptake significantly. Future research into population health approaches to increase HIV prevention should focus on patients with infectious syphilis and other current risk factors for incident HIV infection.
A Comparison of Effectiveness of Thai Traditional Massage and Tamsulosin in Lower Urinary Tract Symptoms: A Randomized Controlled Trial
Authors: Sinsomboon Ongart , Noppakulsatit Patranuch , Tassanarong Adis , Tungsukruthai Parunkul , Sriyakul Kusuma
Published: January 2022

The prospective clinical, non-inferiority study aimed to investigate the effectiveness of Thai traditional massage on lower urinary tract symptoms (LUTS) compared with Tamsulosin in Thai men. It was conducted on men aged 50 to 75 years old with LUTS (N = 45). Participants were blocked four randomly assigned into 2 groups. The control group (n = 25) was received 0.4 mg Tamsulosin daily and the study group (n = 20) was given Thai traditional massage for 4 weeks. The efficacy evaluation was performed by the International Prostate Symptoms Score (IPSS), a Thai version of the World Health Organization Quality of Life Questionnaire (WHO-QoL Brief), Uroflowmetry, and Post-void residual urine (PVR) at baseline and end of study. The background characteristics of participants were not significantly different between groups. Both interventions relieved LUTS in the total IPSS and the quality of life score associated with urination were decreased, described as symptoms and quality of life due to urination improvement after 4 weeks of intervention. Interestingly, the Thai traditional massage has significant improvement in total IPSS and voiding score (p < .05). Additionally, the time to peak flow rate, peak flow rate (Qmax), average flow rate (Qave) and voided volume of both interventions were improved with no statistical significance. PVR was decreased in both interventions. The WHO-QoL brief score was improved the total score. There was no significant difference in terms of uroflowmetry, PVR, and WHO-QoL brief scores compared between groups. The result suggests that Thai traditional massage has the potential to be an alternative treatment for LUTS.
Hoagland Sign as an Aid for Antimicrobial Stewardship—A Case Report
Authors: Nair Lakshmi J. , Reghukumar Aravind , Gurudas Athul , Sasidharan Kirankumar V. , Parvathy Kalyani
Published: January 2022

Hoagland sign is an early and transient bilateral painless upper eyelid edema observed in patients with Epstein-Barr virus (EBV)-related infectious mononucleosis. This sign can predate the appearance of exudative pharyngitis and cervical lymphadenopathy. Usually, this sign disappears by first week of infection. Here, we describe the occurrence of late onset Hoagland sign in a 14-year old boy who presented to us on 10th day of fever. Hoagland sign appeared after 10 days from symptom onset in our patient. Despite persistence of fever, the presence of Hoagland sign which appeared prior to confirmation of EBV infection was a helpful indicator for stopping antibiotics. In view of tonsillar hypertrophy with potential airway compromise and biochemical parameters suggestive of possible secondary hemophagocytic lymphohistiocytosis, he was initiated on steroids with which defervescence and prompt resolution of symptoms occurred. EBV can present as acute undifferentiated febrile syndrome which might result in inappropriate use of antibiotics. This case highlights the importance of using clinical clues like Hoagland sign to optimize antimicrobial stewardship.
Media Generation and Pharmacy Regulatory Authority Awareness
Authors: Boyle Todd A. , Morrison Bobbi , Mahaffey Thomas
Published: January 2022

Background: Professional regulatory authorities play a critical role in protecting public interest. Yet, there is a growing view that trust in regulatory authorities may be on the decline. Objective: Awareness has been identified as important for maintaining trust. However, research that examines public awareness and trust in pharmacy regulatory authorities (PRAs) is lacking. This research explores public awareness and trust of PRAs and presents recommendations to enhance PRA communication strategies. Methods: An online survey was conducted with the Nova Scotia (Canada) public in 2020. Adopting classifications from the Communications literature, 3 media generations were explored: newspaper, television, and the Internet. The χ2 test of independence and Kruskal-Wallis H test were adopted to explore differences between the generations. Results: Six hundred sixty-two usable surveys were obtained. Over 80% of those surveyed were aware of the existence of the PRA. Those who had heard of the PRA were most aware of its operational responsibilities and less aware of its governance. The Internet Generation was more aware that the PRA includes members of the public in its decision making than expected and showed increased trust toward the PRA versus the other media generations. Conclusion: The findings should help inform PRA communication plans and set baselines to assess whether such plans enhance awareness. Future studies should explore additional aspects of PRA awareness and trust, perform comparisons across pharmacy jurisdictions, and develop and test models of the relationship between PRA awareness and various dimensions of institutional trust.
Knowledge-Oriented Leadership, Team Cohesion, and Project Success: A Conditional Mechanism
Authors: Mariam Shahida , Khawaja Kausar Fiaz , Qaisar Muhammad Nawaz , Ahmad Farooq
Published: January 2022

We examined the impact of knowledge-oriented leadership on project success via team cohesion and the moderating role of valuing people and project complexity on this relationship. We collected data from 121 project employees in Pakistan in a two-wave field survey at an interval of 15 days. The results showed a positive association between knowledge-oriented leadership and project success, and team cohesion partially mediated this relationship. Valuing people positively moderated the relationship between knowledge-oriented leadership and team cohesion. Project complexity had a negative but insignificant moderating effect on project success. The theoretical and practical implications of these findings are discussed.