bluuebunny/crossref_metadata_2025 huggingface dataset:
Environmental and hormonal control of body-color polyphenism in Patanga japonica (Orthoptera, Acrididae): Effects of substrate color, crowding, temperature and [His7]-corazonin injection
Authors: Tanaka Seiji , Kayukawa Takumi
Published: January 2024

Patanga japonica (Bolívar) shows various body colors in the field. Most nymphs are green in the summer, but some develop non-green colors, such as yellow, white, brown, reddish, and black, in the fall. Nymphs individually reared in white, yellow-green, and black containers showed green, light-green, white, and reddish body colors, and the substrate color significantly influenced the proportions of green nymphs. A few individuals developed black spots and patterns, and such individuals were most frequently observed in the black containers. Nymphs with distinct black patterns were observed when reared in a group of five individuals per container, and the proportion of such individuals varied slightly depending on the brightness of the substrate color. Singly kept nymphs that were allowed to see five other nymphs in another container turned darker than those that were only allowed to see an empty container, suggesting that visual stimuli without mechanical stimulation induced black patterns. In outdoor cages, nymphs tended to develop more pronounced black patterns during their last instar when the hatching date was delayed and the temperature during the later stages of development was decreased. The effect of temperature during the late stadia was tested by transferring a group of third-stadium nymphs from outdoor cool conditions to a high temperature, while other nymphs were continuously maintained outdoors. Markedly melanized individuals were observed in the outdoor cage, whereas the appearance of such individuals was strongly suppressed at a high temperature. Green nymphs injected with synthetic [His7]-corazonin developed black patterns after ecdysis to the following instars and to the adult stage, and some looked indistinguishable in body color from group-reared nymphs. Nymphs injected with this hormone developed black patterns even at a high temperature. Adults looked similar in body coloration with some variation. Their hindwings turned reddish after overwintering. These results demonstrate that P. japonica exhibits body-color pholyphenism.
Worldwide distribution and phylogeography of the agave weevil Scyphophorus acupunctatus (Coleoptera, Dryophthoridae): the rise of an overlooked invasion
Authors: Viviano Andrea , Cocco Arturo , Colangelo Paolo , Delitala Giuseppe Marco , Pantaleoni Roberto Antonio , Loru Laura
Published: January 2024

Global plant trade represents one of the main pathways of introduction for invertebrates, including insects, throughout the world. Non-native insects include some of the most important pests affecting cultivated and ornamental plants worldwide. Defining the origins and updating the distribution of non-native invasive species is pivotal to develop effective strategies to limit their spread. The agave weevil,Scyphophorus acupunctatus(Coleoptera, Dryophthoridae), is a curculionid beetle native to Central and North America, although it also occurs in Eurasia, Africa, Oceania and South America as a non-native species. Despite being widespread, the extent of occurrence and origins of European populations of the agave weevil have been overlooked. In the present study, the current and potential worldwide distribution ofS. acupunctatuswas assessed and an analysis of its genetic diversity in the native and non-native ranges was performed. By analysing occurrences from local phytosanitary bulletins and citizen-science platforms, the agave weevil was confirmed to be widely distributed and to occur on all continents, except Antarctica. Additionally, there is potential for expansion throughout the world, as estimated by species distribution models. Nucleotide and haplotype diversity of the COXI mitochondrial gene (about 650 bp) was lower in the non-native (n = 39 samples) than native populations (n = 26 samples). The majority of introduced individuals belonged to the same haplotype, suggesting that most introductions in Europe might have occurred from a small geographical area in Central America. Constant transboundary monitoring and national laws must be considered to reduce the spread of the agave weevil, given that a bridgehead effect may occur from non-native populations to new suitable areas.
Développer le pouvoir d’agir des praticiens hospitaliers, pour « bien faire » et impacter : le cas du centre hospitalier Calvi-Balagne
Authors: Moretti Romain , Frimousse Soufyane
Published: January 2024

La crise sanitaire de la covid 19 qui semblait sonner la fin de l’hôpital public, a conduit à une prise de conscience accélérée, de la part des acteurs hospitaliers et des pouvoirs publics, des maux du secteur de la santé publique. L’essor du Nouveau Management Public caractérisé au sein de l’hôpital public par une hybridation de rôle des professionnels de santé, conduit à une perte de sens au travail chez ces derniers et à un choc entre identités professionnelles au sein de la structure, avec d’un coté la sphère administrative et de l’autre la sphère praticienne. Afin de répondre à ces enjeux, cet article s’intéresse à l’essor du pouvoir d’agir, qui offre au collaborateur des conditions pour tendre vers l’essence de son métier et ainsi contribuer à la construction, ou la reconstruction, du sens au travail pour les professionnels de santé. La méthodologie qualitative mobilisée dans cette étude met en évidence, à travers la réalisation de cartes cognitives et d’entretiens semi directifs, les points de rapprochement entre les visions administratives et praticiennes. Les résultats invitent à dépasser l’idée d’un « médecin-gestionnaire » pour tendre vers une approche systémique et apprenante, permise par l’essor d’un environnement capacitant.
A SAFER Workplace: Broadening Peer Support Programs
Authors: Vermylen Julia H. , Burnett-Zeigler Inger , Agarwal Gaurava
Published: January 2024

Mistreatment from patients and their visitors is a troubling problem affecting the majority of physicians throughout their career and disproportionately impacting female and nonwhite physicians. This article reviews the prevalence and impact of mistreatment of physicians from patients and their visitors and reviews steps that organizations can take to address mistreatment from patients. Additionally, this article highlights a unique opportunity to expand peer support programs to provide trauma-informed emotional first aid to physicians after episodes of mistreatment and provides a communication roadmap, SAFER, to guide peer supporters.

[
Psychiatr Ann
. 2024;54(1):e3–e8.]
Exertional Heat Illness—From Identifying Heat Rash to Treating Heat Stroke
Authors: Danzig Rachel M. , Raunig Jefferey M. , Acholonu Chidimma J.
Published: January 2024

Heat-related illness commonly affects adolescent patients, especially as summer approaches and global temperature extremes worsen. Basic counseling on sunburn prevention can decrease the risk for future malignancies, and rapidly preventing, identifying, and treating heat stroke can prevent severe morbidity and mortality. This article will review the epidemiology of exertional heat-related illness and the variations in presentations and pathology, from heat rash and sunburn to heat exhaustion and heat stroke. By the end of this review clinicians should be able to identify and treat different heat-related illnesses in adolescents and potentially save a life.

[
Pediatr Ann
. 2024;53(1):e17–e21.]
A generalized quantum cluster algebra of Kronecker type
Authors: Bai Liqian , Chen Xueqing , Ding Ming , Xu Fan
Published: January 2024

The notion of generalized quantum cluster algebras was introduced as a natural generalization of Berenstein and Zelevinsky's quantum cluster algebras as well as Chekhov and Shapiro's generalized cluster algebras. In this paper, we focus on a generalized quantum cluster algebra of Kronecker type which possesses infinitely many cluster variables. We obtain the cluster multiplication formulas for this algebra. As an application of these formulas, a positive bar-invariant basis is explicitly constructed. Both results generalize those known for the Kronecker cluster algebra and quantum cluster algebra.
BUILDING THE REPLICA THAMES BARGE BLUE MERMAID
Authors: Titchener R D , Spooner P
Published: January 2024

The building of a replica steel engineless Thames Sailing Barge, the Blue Mermaid, based on an original design from 1930; the design process; doing this within the modern regulatory framework; observations on engineless operation and the developing sail cargo initiative.
Territoires zéro chômeur de longue durée
Authors: Semenowicz Philippe , Fretel Anne , Jany-Catrice Florence , Vatan Sylvain
Published: January 2024

L’expérimentation territoires zéro chômeur de longue durée (TZC) a été introduite dans le débat public comme un « nouveau modèle » de lutte contre le chômage de longue durée. Pourtant, le projet présente dès l’origine des similitudes avec les dispositifs de l’insertion par l’activité économique (IAE). Dans quelle mesure TZC constitue-t-il une rupture avec l’IAE ? Sur la base d’une enquête de terrain menée durant trois ans sur l’un des territoires ayant expérimenté TZC, complétée par une série d’entretiens semi-directifs auprès d’acteurs nationaux du projet, nous abordons cette question sous l’angle d’une comparaison de leurs modèles socioéconomiques respectifs. Nous mettons en évidence combien l’ambition originelle du projet le positionne à distance des évolutions de l’IAE. Pour autant, l’opérationnalisation de l’expérimentation produit des formes de convergence avec cette dernière.
On Aristotelian Essence
Authors: Khodadadi Hossein
Published: January 2024

The concept of essence holds a pivotal role in unraveling Aristotle’s metaphysical framework. In his exploration of Metaphysics, Aristotle delves into the quest for fundamental being, positing that the primary substance is essentially synonymous with essence. This paper examines the criteria for essence, drawing from both the Categories and Metaphysics Z. Two distinct perspectives on essentialism, namely individual essentialism, aligned with the contemporary modal account of essence, and kind essentialism, are scrutinized. Through a critical analysis, this paper contends that both these essentialist accounts fall short in adequately elucidating the Aristotelian concept of essence. Consequently, this pivotal notion, governed by Aristotelian criteria, remains a perplexing enigma, challenging contemporary attempts to fully grasp its intricacies.
Top-down and bottom-up constraints in mechanistic inquiry
Authors: Diesel Werberich Matheus
Published: January 2024

Mechanisms play a crucial role in scientific research across various disciplines, and philosophers of science have devoted significant effort into understanding their ontology and epistemology. This paper examines the relationship between mechanisms and phenomena, highlighting the inherent dependence of mechanistic delineation on the characterization of phenomena. By acknowledging that characterizing phenomena is influenced by pragmatic considerations and research interests, the paper argues that mechanistic inquiry is inherently shaped by researchers’ perspectives. This dependence raises concerns about the possibility of a realist view of mechanisms. To address these concerns, the paper explores how top-down constraints, rooted in researchers’ interests and pragmatic concerns, can be balanced by bottom-up constraints derived from empirical considerations. In conclusion, I argue that the interplay between these constraints forms an empirical and realist counterweight to the perspectival nature of top-down constraints.
Soberania nacional, direitos humanos e o paradoxo democrático:
Authors: Ferreira Lacerda Moara , Corrêa de Araujo Ricardo , Pensabem Ribeiro Filho Marcos Aurélio
Published: January 2024

O artigo pretende analisar e sugerir uma saída para o paradoxo democrático, o dilema moral constitutivo entre a soberania nacional do Estado democrático liberal e o reconhecimento dos direitos humanos dos estrangeiros, apontado por Donatella Di Cesare. Para isso, serão reconstruídos o referido paradoxo, a partir das críticas da autora a Michael Walzer e David Miller, e a solução apontada por ela, que envolve a superação da ordem estadocêntrica e a criação de uma comunidade política que não seja centrada na identidade nacional. Em seguida, serão sucessivamente analisadas as posições de tais autores, mostrando-se que as críticas feitas por Di Cesare não correspondem aos trabalhos desenvolvidos por eles sobre comunidade política e identidade nacional. Por fim, será sugerido que há congruências entre esses três autores que poderiam ajudar na construção conceitual de um conceito de comunidade política capaz de oferecer uma direção inicial de saída do paradoxo democrático.
Study on Shape Effect of MHD Radiative Ag-Water and CuO-Water Nanofluid Flow in a Semi-Porous Channel
Authors: Paul Dhanonjoy Chandra , Hye Md. Abdul , Islam Md. Maidul , Hosen Md. Zakir , Alam Md. Sarwar
Published: January 2024

This paper studies the two-dimensional unsteady incompressible Ag-water and CuO-water nanofluid flow in a semi-porous expanding-contracting channel in the presence of thermal radiation effect. The continuity equation, Navier-Stokes equation, and energy equation governing the model are transformed into a set of non-dimensional ordinary differential equations using appropriate transformations. These dimensionless governing equations are solved using power series with the aid of the Hermite-Padé approximation method. The influences of physical parameters such as Reynolds number, expansion ratio, solid volume fraction, Prandtl number, Magnetic parameter, and shape factor are depicted in velocity and temperature profiles. Moreover, the average Nusselt number and skin friction coefficient are also investigated with the effect of Reynolds number, solid volume fraction, and expansion ratio. It is observed that the heat transfer rate decreases significantly as the shape factor increases.
Physical Experiments and DEM Simulations for Erosion of Iron Target by Two Impingements of Al2O3 Particle with Impingement Angles of Double 90º
Authors: Fang Zi Qiang , Peng Song Lin
Published: January 2024

In mechanical equipment interacting with impingement particles, worn surface morphology of parts and components is formed by an accumulative action of a large number of single-particle erosions. To exhibit the mechanism of multi-particle erosion of target, three physical experiments and Discrete Element Method (DEM) simulations of erosion of iron target by the two vertical impingements of Al2O3 particle are carried out under three different landing errors x of the two impingements. The experimental results showed that each of two overlapping worn morphologies by the two impingements has an spherical cap shape. When x is larger than radius R1 of worn morphology of target by the first erosion, two morphologies with an spherical cap shape are very close in size; while the size of worn morphology by the second erosion increases with the decrease of x, when x is smaller than R1. The predicting worn morphologies by DEM are almost consistent with the experimental results, where the maximum relative deviation in size of worn morphology is 2.98% in the direction along x, and is 3.93% in the direction perpendicular to x. All these proved the effectiveness of the DEM model in predicting erosion of target by two impingements of particle.
Development of Manufacturing Process for High-Chromium Steel Large Welding Roll
Authors: Kukhar Volodymyr V. , Vasylevskyi Oleg , Malii Khrystyna , Zurnadzhy Vadym , Efremenko Bohdan , Sili Ivan
Published: January 2024

Due to the operating conditions of weld and calibrating rolls used in the production processes of large electric-welded pipes, their material is subject to stringent wear and abrasion resistance requirements at high temperatures. The limited capabilities of conventional Cr-Mn-Ni tool steels and open die forging technologies with heat treatment processes do not provide the required performance properties for large welded rolls. Therefore, the material of the product was replaced with Cr12MoV high-chromium steel. This required identifying the formation patterns of the fine grain structure of high-chromium steel in order to adjust the production technology with adaptation to the unique conditions and equipment (12.5 MN hydraulic forging press, heating and thermal furnaces) of the forging shop. The technology was offered, which included the development of modes from heating to heat treatment with intermediate two-stage forging from Cr12MoV steel ingots in two sets of combined dies. At the first stage, deformation with a low reduction ratio ε = 5% and a relative feed rate of 0.4 per pass was provided to break and refine the carbide mesh, and at the second stage, intense deformation with a reduction ratio ε = 15% was performed. Further practical application has shown that the durability of weld rolls made from the new material increases by 20–30%.
Oxidized Low-Density Lipoprotein Accumulation in Macrophages Impairs Lipopolysaccharide-Induced Activation of AKT2, ATP Citrate Lyase, Acetyl–Coenzyme A Production, and Inflammatory Gene H3K27 Acetylation
Authors: Ting Kenneth K Y , Yu Pei , Iyayi Mudia , Dow Riley , Hyduk Sharon J , Floro Eric , Ibrahim Hisham , Karim Saraf , Polenz Chanele K , Winer Daniel A , Woo Minna , Rocheleau Jonathan , Jongstra-Bilen Jenny , Cybulsky Myron I
Published: January 2024

The accumulation of lipid and the formation of macrophage foam cells is a hallmark of atherosclerosis, a chronic inflammatory disease. To better understand the role of macrophage lipid accumulation in inflammation during atherogenesis, we studied early molecular events that follow the accumulation of oxidized low-density lipoprotein (oxLDL) in cultured mouse macrophages. We previously showed that oxLDL accumulation downregulates the inflammatory response in conjunction with downregulation of late-phase glycolysis. In this study, we show that within hours after LPS stimulation, macrophages with accumulated oxLDL maintain early-phase glycolysis but selectively downregulate activation of AKT2, one of three AKT isoforms. The inhibition of AKT2 activation reduced LPS-induced ATP citrate lyase activation, acetyl-CoA production, and acetylation of histone 3 lysine 27 (H3K27ac) in certain inflammatory gene promoters. In contrast to oxLDL, multiple early LPS-induced signaling pathways were inhibited in macrophages with accumulated cholesterol, including TBK1, AKT1, AKT2, MAPK, and NF-κB, and early-phase glycolysis. The selective inhibition of LPS-induced AKT2 activation was dependent on the generation of mitochondrial oxygen radicals during the accumulation of oxLDL in macrophages prior to LPS stimulation. This is consistent with increased oxidative phosphorylation, fatty acid synthesis, and oxidation pathways found by comparative transcriptomic analyses of oxLDL-loaded versus control macrophages. Our study shows a functional connection between oxLDL accumulation, inactivation of AKT2, and the inhibition of certain inflammatory genes through epigenetic changes that occur soon after LPS stimulation, independent of early-phase glycolysis.
Management of large traumatic pneumothorax: when the patient is an experienced Internist
Authors: Artom Nathan , Maineri Paola , Paris Luca , Lagasio Chiara , Artom Francesco , Artom Patrizia , Artom Alberto
Published: January 2024

Traumatic pneumothorax is traditionally treated with tube thoracostomy. We report a case of conservative management of a large traumatic pneumothorax, due to the close collaboration between the physician, a Thoracic Surgeon and the patient, a retired Internist.
On the unlocked secrets of the lymphatics and lymphatic circulation
Authors: Pansini Giancarlo
Published: January 2024

The glory of having discovered the lymphatic vessels belongs undoubtedly to the Italian Gaspare Aselli from Cremona; he established itself as an excellent anatomist and surgeon, also military, in Milan, where the first true description of the lymphatic system can really begin; later, he moved to Pavia, where in 1624 he obtained the chair of anatomy.
Association of DNA methylation/demethylation with the functional outcome of stroke in a hyperinflammatory state
Authors: Wang Yubo , Zhang Ling , Lyu Tianjie , Cui Lu , Zhao Shunying , Wang Xuechun , Wang Meng , Wang Yongjun , Li Zixiao
Published: January 2024

Inflammation is closely related to stroke prognosis, and high inflammation status leads to poor functional outcome in stroke. DNA methylation is involved in the pathogenesis and prognosis of stroke. However, the effect of DNA methylation on stroke at high levels of inflammation is unclear. In this study, we constructed a hyperinflammatory cerebral ischemia mouse model and investigated the effect of hypomethylation and hypermethylation on the functional outcome. We constructed a mouse model of transient middle cerebral artery occlusion and treated the mice with lipopolysaccharide to induce a hyperinflammatory state. To investigate the effect of DNA methylation on stroke, we used small molecule inhibitors to restrain the function of key DNA methylation and demethylation enzymes. 2,3,5-Triphenyltetrazolium chloride staining, neurological function scores, neurobehavioral tests, enzyme-linked immunosorbent assay, quantitative reverse transcription PCR and western blot assay were used to evaluate the effects after stroke in mice. We assessed changes in the global methylation status by measuring DNA 5-mc and DNA 5-hmc levels in peripheral blood after the use of the inhibitor. In the group treated with the DNA methylation inhibitor, brain tissue 2,3,5-triphenyltetrazolium chloride staining showed an increase in infarct volume, which was accompanied by a decrease in neurological scores and worsening of neurobehavioral performance. The levels of inflammatory factors interleukin 6 and interleukin-1 beta in ischemic brain tissue and plasma were elevated, indicating increased inflammation. Related inflammatory pathway exploration showed significant overactivation of nuclear factor kappa B. These results suggested that inhibiting DNA methylation led to poor functional outcome in mice with high inflammation following stroke. Further, the effects were reversed by inhibition of DNA demethylation. Our findings suggest that DNA methylation regulates the inflammatory response in stroke and has an important role in the functional outcome of hyperinflammatory stroke.
Music software with a Machine Learning-based feedback system as an alternative for initial piano study in children
Authors: Borja Acevedo Miguel Angel , Camargo Mendoza Jorge Eliecer
Published: January 2024

As evidenced in the literature, music has accompanied the human being for millennia, in different situations, emotions, and activities. In addition, not only does it allow expressions of internal personal states and feelings, but it can also produce many positive effects on those who practice it. Various authors have explored these benefits that musical activity brings, mainly in children. They highlight positive aspects of learning music in different areas of knowledge, in school performance and even improvements in the IQ of infants. However, despite the large number of studies regarding the benefits of music in children and the different nascent teaching alternatives, in Colombia the situation continues to be dramatic in terms of the incorporation of musical activity in the school curriculum. The foregoing added to political factors, teaching spaces and teacher training. In this way, the present work offers a new musical learning alternative, aimed at children from 7 to 11 years old, through musical software focused on the initial teaching of the instrumental keyboard. It is important to mention that the software has a feedback system based on decision trees, which allows reinforcing the topics covered in the application. Finally, a comparative analysis is presented between teaching using the software and traditional teaching with the book, through an Investigation-Action carried out over six days with two students from a public school in the city of Bogotá, Colombia. This investigation action allowed us to observe positive results based on the comments and performance of the participants, which opens a great possibility for the subsequent scaling of this application.
О качественных свойствах решения одной краевой задачи для системы нелинейных интегральных уравнений
Authors: Khachatryan Khachatur Aghavardovich , Petrosyan Haykanush Samvelovna
Published: January 2024

Исследуется одна краевая задача для системы нелинейных интегральных уравнений на полуоси, матричное ядро которой имеет единичный спектральный радиус. эта краевая задача имеет приложения в различных областях физики и биологии. в частности, такие задачи возникают в динамической теории $p$-адических струн для скалярного поля тахионов, в математической теории распространения эпидемий, в кинетической теории газов и в теории переноса излучения. обсуждаются вопросы существования, отсутствия и единственности нетривиального решения этой краевой задачи. доказано, что краевая задача с нулевыми краевыми условиями на бесконечности имеет только тривиальное решение в классе неотрицательных и ограниченных функций. также доказано, что если хотя бы одно из краевых значений на бесконечности положительно, то эта задача имеет нетривиальное решение, которое является выпуклым, неотрицательным, ограниченным и непрерывным. приведены примеры матричных ядер и нелинейностей, удовлетворяющих всем условиям доказанных теорем.
Clinical value of oral contrast-enhanced ultrasonography in diagnosis of gastric tumors
Authors: Wang Chuan-Yu , Fan Xiao-Jing , Wang Fei-Liang , Ge Yue-Yue , Cai Zhao , Wang Wei , Zhou Xin-Ping , Du Jun , Dai De-Wei
Published: January 2024

BACKGROUND

The incidence of gastric cancer remains high, and it is the sixth most common cancer and the fourth leading cause of cancer deaths worldwide. Oral contrast-enhanced ultrasonography is a simple, non-invasive, and painless method for the diagnosis of gastric tumors.

AIM

To explore the diagnostic value of oral contrast-enhanced ultrasonography for the detection of gastric tumors.

METHODS

The screening results based on oral contrast-enhanced ultrasonography and electronic gastroscopy were compared with those of the postoperative pathological examination.

RESULTS

Among 42 patients with gastric tumors enrolled in the study, the diagnostic accordance rate was 95.2% for oral contrast-enhanced ultrasonography (n = 40) and 90.5% for electronic gastroscopy (n = 38) compared with postoperative pathological examination. The Kappa value of consistency test with pathological findings was 0.812 for oral contrast-enhanced ultrasonography and 0.718 for electronic gastroscopy, and there was no significant difference between them (P = 0.397). For the TNM staging of gastric tumors, the accuracy rate of oral contrast-enhanced ultrasonography was 81.9% for the overall T staging and 50%, 77.8%, 100%, and 100% for T1, T2, T3, and T4 staging, respectively. The sensitivity and specificity were both 100% for stages T3 and T4. The diagnostic accuracy rate of oral contrast-enhanced ultrasonography was 93.8%, 80%, 100%, and 100% for stages N0, N1-N3, M0, and M1, respectively.

CONCLUSION

The accordance rate of qualitative diagnosis by oral contrast-enhanced ultrasonography is comparable to that of gastroscopy, and it could be used as the preferred method for the early screening of gastric tumors.
Mechanism of pachymic acid in the treatment of gastric cancer based on network pharmacology and experimental verification
Authors: Du Yu-Hua , Zhao Jian-Jun , Li Xia , Huang Shi-Cong , Ning Na , Chen Guo-Qing , Yang Yi , Nan Yi , Yuan Ling
Published: January 2024

BACKGROUND

Pachymic acid (PA) is derived from Poria cocos. PA has a variety of pharmacological and inhibitory effects on various tumors. However, the mechanism of action of PA in gastric cancer (GC) remains unclear.

AIM

To investigate the mechanism of PA in treating GC via the combination of network pharmacology and experimental verification.

METHODS

The GeneCards and OMIM databases were used to derive the GC targets, while the Pharm Mapper database provided the PA targets. Utilizing the STRING database, a protein-protein interaction network was constructed and core targets were screened. The analyses of Gene Ontology, Kyoto Encyclopedia of Genes and Genomes (KEGG), and gene set enrichment analysis were conducted, and molecular docking and clinical correlation analyses were performed on the core targets. Ultimately, the network pharmacology findings were validated through in vitro cell assays, encompassing assessments of cell viability, apoptosis, cell cycle, cloning, and western blot analysis.

RESULTS

According to network pharmacology analysis, the core targets were screened, and the PI3K/AKT signaling pathway is likely to be the mechanism by which PA effectively treats GC, according to KEGG enrichment analysis. The experimental findings showed that PA could control PI3K/AKT signaling to prevent GC cell proliferation, induce apoptosis, and pause the cell cycle.

CONCLUSION

Network pharmacology demonstrated that PA could treat GC by controlling a variety of signaling pathways and acting on a variety of targets. This has also been supported by in vitro cell studies, which serve as benchmarks for further research.
Impact of propofol and sevoflurane anesthesia on cognition and emotion in gastric cancer patients undergoing radical resection
Authors: Li Ao-Han , Bu Su , Wang Ling , Liang Ai-Min , Luo Hui-Yu
Published: January 2024

BACKGROUND

Propofol and sevoflurane are commonly used anesthetic agents for maintenance anesthesia during radical resection of gastric cancer. However, there is a debate concerning their differential effects on cognitive function, anxiety, and depression in patients undergoing this procedure.

AIM

To compare the effects of propofol and sevoflurane anesthesia on postoperative cognitive function, anxiety, depression, and organ function in patients undergoing radical resection of gastric cancer.

METHODS

A total of 80 patients were involved in this research. The subjects were divided into two groups: Propofol group and sevoflurane group. The evaluation scale for cognitive function was the Loewenstein occupational therapy cognitive assessment (LOTCA), and anxiety and depression were assessed with the aid of the self-rating anxiety scale (SAS) and self-rating depression scale (SDS). Hemodynamic indicators, oxidative stress levels, and pulmonary function were also measured.

RESULTS

The LOTCA score at 1 d after surgery was significantly lower in the propofol group than in the sevoflurane group. Additionally, the SAS and SDS scores of the sevoflurane group were significantly lower than those of the propofol group. The sevoflurane group showed greater stability in heart rate as well as the mean arterial pressure compared to the propofol group. Moreover, the sevoflurane group displayed better pulmonary function and less lung injury than the propofol group.

CONCLUSION

Both propofol and sevoflurane could be utilized as maintenance anesthesia during radical resection of gastric cancer. Propofol anesthesia has a minimal effect on patients' pulmonary function, consequently enhancing their postoperative recovery. Sevoflurane anesthesia causes less impairment on patients' cognitive function and mitigates negative emotions, leading to an improved postoperative mental state. Therefore, the selection of anesthetic agents should be based on the individual patient's specific circumstances.
Sectoral Intergovernmental Relations in Ethiopia Federation: Normative and Empirical Considerations
Authors: Nigussie Afesha
Published: January 2024

Policy overlap or functional interface is inevitable in all federations. In Ethiopia, federal sectoral offices depend on the regional state institutions to execute most of their policy, programs, and decisions. The policy overlap and functional interface demands the entrenchment of sectoral forums that facilitate interactions, consultation, and cooperation between federal and state sectoral offices to deal with functional interface and spillover. Yet, formal sectoral forums are not institutionalized. Previous studies reveal that there is no much study that shows how sectoral relations and interactions are conducted in various policy sectors. This article examines sectoral IGR using the practices of selected federal-state and interstate sectoral relations. It reveals that the established formal sectoral IGR forums have remained dysfunctional. Yet, there are several informal sectoral meetings (conferences) between the federal and state sectoral institutions or among state sectoral bureaus. The vertical sectoral meetings are organized by the federal sectoral offices which also set the agenda of the meetings. The federal sectoral personnel are also overrepresented. These matters negate the co-equal status expected in federal-state relations. In most of the sectoral IGR, there are no written rules that regulate their meetings and decision-making procedures except the relations that exist between the Ministry of Health and state health bureaus regulated by an internal bylaw. However, horizontal sectoral relations are regulated by interstate agreements.
Lošinj: From a sailor´s island to a fashionable hotspot for health tourism in Austria-Hungary
Authors: Wiltos Victoria
Published: January 2024

This article discusses the historical development of tourism on the Croatian island of Lošinj, which underwent a transformation from a hub for goods to a popular destination for health tourism during the winter. The paper explores the factors that contributed to the development of tourism on Lošinj and places its history in a broader context, shedding light on new medical aspirations, the Austrian authorities’ will to vitalize the Austrian Littoral, and the emergence of a new era of tourism to the sea. With over 8000 visitors arriving at the island in the Kvarner during the peak years of 1912/13, Lošinj was the first island of the Austrian Riviera where tourism had been able to develop.
Művészetoktatás online térben pandémia idején – tapasztalatok, kihívások és megoldások
Authors:   University of Arts Târgu Mureş, Vargancsik-Thörik Krisztina Iringó
Published: January 2024

The coronavirus pandemic (COVID-19), which lasted for almost two years (2020-2022), paralyzed education systems around the world and Romania was no different. The quick transition to online education has faced many obstacles, including lack of equipment, lack of network coverage and limited digital skills among teachers and students. The chaos in the education system also affected teachers of the arts in Romania. I summarize the experiences, challenges and solutions of this period in this paper. I used a 31-question structured interview to assess the experiences of online arts education and interviewed nine teachers coming from diverse areas of teaching, such as music, visual arts and drama in a metropolitan Transylvanian context of Romania
Respon metabolik sapi madura pada musim masah di Kabupaten Pamekasan
Authors: Agustina Desi K. , Kuswati Kuswati , Kurnadi Bambang , Hidayati Nurul
Published: January 2024

Abstract 
The purpose of this study was to evaluate the effect of environmental factors, namely seasonal changes and nutritional factors on the adaptive abilities shown by the metabolic response of Madura cattle. The research was conducted in Pademawu District, Pamekasan Regency, East Java from February to June 2022. The research material included 45 Madura cattle which included differences in sex and age. Metabolic response was analyzed descriptively. The results of the study obtained blood urea nitrogen (BUN) concentrations in male and female Madura cattle with different ages, including; 20.96 ± 6.79; 22.04 ± 5.12; 18.63 ± 1.94; 15.86 ± 2.72; 27.42 ± 14.5; 21.40 ± 8.2. Triglyceride concentrations in Madura cattle successively at different sexes and ages, namely; 11.00 ± 3.53; 21.60 ± 7.4; 11.00 ± 1.94; 12.00 ± 2.72; 9.20 ± 5.65; 11.00 ± 2.40. Glucose concentrations in male and female Madura sai with different ages, namely; 83.00 ± 16.90; 102.40 ± 13.90; 97.60 ± 12.60; 110.00 ± 13.3; 95.00 ± 8.4; 54.80 ± 8.7. Blood protein concentrations respectively; 7.70 ± 1.28; 10.30 ± 2.09; 10.14 ± 2.48; 9.16 ± 1.73; 9.56 ± 2.01; 6.16 ± 1.55. In general, the metabolic response of male and female Madura cattle at different age levels in the wet season is within the normal range. This shows that it can adapt well.
Keywords: Madura cattle; Metabolic; Response; Season
 
Abstrak
 Tujuan penelitian ini adalah mengevaluasi respon metabolik sapi Madura pada musim basah. Materi penelitian meliputi 45 ekor sapi Madura yang meliputi perbedaan jenis kelamin dan umur. Respon metabolic dianalisis secara deskriptif, hasil penelitian didapatkan konsentrasi Blood urea nitrogen (BUN) pada sapi Madura jantan dan betina dengan umur berbeda antara lain: 20,96 ± 6,79; 22,04 ± 5,12; 18,63 ± 1,94; 15,86 ± 2,72; 27,42 ± 14,5; 21,40 ± 8,2. Konsentrasi trigliseride pada sapi Madura berturut-turut pada jenis kelamin dan umur yang berbeda yaitu; 11,00 ± 3,53; 21,60 ± 7,4; 11,00 ± 1,94; 12,00 ± 2,72; 9,20 ± 5,65; 11,00 ±  2,40. Konsentrasi Glukosa pada sapi Madura jantan dan betina dengan umur berbeda yaitu: 83,00 ± 16,90; 102,40 ± 13,90; 97,60 ± 12,60; 110,00 ± 13,3; 95,00 ± 8,4; 54,80 ± 8,7. Konsentrasi protein darah berturut-turut: 7,70 ± 1,28; 10,30 ± 2,09; 10,14 ± 2,48; 9,16 ± 1,73; 9,56 ± 2,01; 6,16 ± 1,55. Respon metabolic sapi Madura jantan maupun betina pada tingkatan umur yang berbeda di musim basah berada dalam kisaran normal.
Kata kunci: Metabolik; Musim; Respon; Sapi Madura
Financial Performance and Potential Feasibility of Black Rice (Oryza sativa L. Indica) Cultivation in Assam: An Empirical Study
Authors: Hazarika Bidyutt Bikash
Published: January 2024

"This paper explores the economic and financial performance of black rice production in the upper Brahmaputra valley region of Assam. Black rice, known for its rich nutritional value and cultural significance, has gained attention from agri-entrepreneurs and development projects aiming to promote its cultivation. The study employs various accounting ratios, such as gross profit ratio, profit-volume ratio, and expenses ratio, to assess the profitability and financial health of black rice farmers in three different categories based on farm size. Through a comprehensive analysis of primary data collected from 170 farmers, the study reveals that category C farmers, with the largest farm size, achieve the highest average gross profit and gross profit ratio, followed by category B and category A. Similarly, category C farmers incur higher expenses on machinery and fertilizers but maintain the lowest expense ratio. Conversely, category A farmers have the highest expense ratio but achieve the lowest average gross profit and profit volume ratio. Break-even analysis and margin of safety are employed to understand the profitability and financial strength of black rice farmers. The study finds that category C farmers have the highest break-even point and the highest margin of safety ratio, followed by category B and category A. The research concludes that black rice cultivation holds immense potential for economic growth and livelihood improvement in Assam. However, despite favorable agro-climatic conditions, commercial production remains limited. Further research is needed to understand the barriers to scale up production and promote the systematic adoption of black rice cultivation to achieve nutritional security and enhance livelihoods in the region."
Digital Marketing and its Role in Customer Acquisition
Authors: Melinevskyi Andrii
Published: January 2024

"The study examines the role of digital marketing in customer acquisition. The relevance of this research is driven by the fact that marketing is increasingly encompassing various industries today. One of its main tasks is to acquire new customers. At the same time, the growing number of companies producing goods with similar specifications means that marketing is beginning to use the latest technologies to increase its target audience actively. As a result, the topic of digital marketing’s role in the cultivation of customer loyalty is becoming an acute issue. The study aims to discover the role of digital marketing in customer acquisition. The research object is digital marketing strategies. Research methods. The following research methods were employed in this paper: description, analysis and synthesis, comparison, generalization, and modelling. The article is dedicated to unravelling the role of digital marketing in customer acquisition. The authors describe the impact of factors such as the virtual space, competition, the accessibility of the average consumer to the Internet, and the lack of qualified personnel in marketing on the application of digital marketing in business activities. The study characterizes the essence of the “digital marketing” concept in broad and specific contexts. In addition, the authors identified the advantages of digital marketing and its components. The article analyzes the main features of digital marketing applied to customer acquisition. They include the Internet, mobile devices, digital television, interactive screens, and local networks. The article summarizes digital marketing methods for attracting customers. The authors investigate customer acquisition methods such as contextual advertising, retargeting, mobile marketing, viral marketing, Big Data, RTB, SMM, SEO, SMO, SEM, and email marketing. During the research, a model was developed that presents the main trends associated with digital marketing in the context of customer acquisition. These trends include ads harmoniously embedded in content, online advertising being widely present in the virtual space, advertising customized to a specific category’s needs, advertising in various formats, and customer acquisition by forming a virtual community. This article categorizes customer acquisition tools into three groups: paid resources, owned resources, and earned resources."
Vectors and Mechanisms of Japan’s Influence for the Development of the Countries of East Asia
Authors: Oliynyk O.
Published: January 2024

The article analyzes the role of Japan in East Asia, as well as defines the vectors and mechanisms of its influence on the countries of the region. The country of the Rising Sun takes an active part in international development, cooperates with international organizations, acts as an active initiator of various international development programs and is one of the largest donors in the world. It was established that Japan constantly provides economic support to ASEAN countries, in particular in the form of official development assistance, builds infrastructure, contributes to the formation of the economic environment, provides technical assistance, promotes the development of human resources, education and health care. The study clarifies the main principles of Japan’s foreign policy regarding international cooperation in their historical development. The author presented the essence of the main doctrines of the Japanese government on supporting the development of SA countries. A comparative analysis of the global initiatives of Tokyo and Beijing and directions of interaction between China and Japan was conducted. The attitude of the ASEAN countries regarding the role of Japan in East Asia is clarified. According to the results of the conducted research, certain conclusions were made regarding the influence of Japan on EA. First, Japan remains a supporter of EA’s policy of peace and prosperity, therefore it takes an active position in ensuring peace and stable development of the region. Secondly, the country’s leadership considers the region in a broader format, more open to the outside world, therefore supports the idea of Indo-Pacific regionalization. Thirdly, Tokyo gives preference to the economic development of EA and implements various regional development mechanisms, in particular: official aid, direct investment and other forms of support. Fourth, the Japanese leadership is aware of China’s power and role in the EA, but adheres to the position of constructive cooperation and avoidance of confrontation. Fifth, Japanese political circles believe that the role of the region in the global processes of globalization will grow, so it is important to take a constructive position regarding interaction with the EA and form a new vision of regional integration.
Environmental Consequences of the Explosion of the Kahovsky Hydroelectric Plant on Biodiversity
Authors: Nepsha Oleksandr , Hryshko Svitlana , Prokhorova Larysa , Zavialova Tetiana , Lysenko Valeriy
Published: January 2024

The purpose of this article is to determine the ecological consequences of the explosion of the Kakhovka hydroelectric plant (southern Ukraine) on the biological diversity of the region. The main research methods were: theoretical generalization and system-functional approach, analysis, synthesis, expedition method. The ecological consequences of the destruction of a hydroelectric dam are divided into two types: drainage and flooding. As a result of the flooding, 48 objects of the nature reserve fund, with a total area of 120 thousand hectares, were affected. Aquatic biotopes and biotopes characteristic of overmoistened areas were the most affected by drainage. 38 rare types of biotopes, which are under the protection of the Bern Convention, were affected by the ecological disaster; wetlands of international importance (so-called Ramsar) with an area of 33,000 hectares in the Dnipro delta and seven objects of the Emerald network. Prospects for further research are related to the study of biotope restoration after an ecological disaster.
Digital Technologies and Project Management as the Basis of Competitiveness of the Distance Business Education
Authors: Ivanova Nataliia , Ivanets Sergii , Krylov Denys , Kharchenko Yuliia , Povna Svitlana , Bondarenko Andrii
Published: January 2024

The purpose of the study is to identify the features of ensuring the competitiveness of distance business education and modern trends in the development of the field of educational services and the role of digital technologies and project management in these processes. General scientific and special methods are used: historical-logical grouping (systematization of electronic learning system elements, distance education, approaches of project management etc.); generalization (understanding of modern role and evaluation of distance education and e-learning resources, digitalization processes). It has been proven that such an alternative to traditional formal education is more closely correlated with the demands of the labour market, allows to better and more quickly meet the needs of employers, and for employees to ensure their professional development throughout their life and to apply their competencies in the countries of the European Union. Approaches to project management in distance business education are described. It has been established that project management in business education has a scientific basis based on pedagogical theories and researches, which supports active, collaborative and critical learning, and also promotes the development of skills that are important in today's information society and the labour market.