bluuebunny/crossref_metadata_2025 huggingface dataset:
The Deep Eutectic Solvent in Used Batteries as an Electrolyte Additive for Potential Chitosan Solid Electrolyte Membrane
Authors: Wahyusi Kindriari Nurma , Puspitawati Ika Nawang , Wirayudha Abdul Rachman
Published: August 2023

The electrolyte or ion conductor acts as a bridge to transfer the ions the electrodes generate. In general, electrolytes are in the form of liquids. However, liquid electrolytes have drawbacks, including needing to be more practical and leaking quickly. Therefore, people switch to solid matrix electrolytes as battery electrolytes. An ideal solid electrolyte membrane must have chemical stability, thermal stability, high ionic conductivity, high flexibility, low cost, and abundant material availability. Lithium extraction from used batteries using Deep Eutectic Solvent (DES) was found to be an intelligent solvent. Mixing the method with lithium salt on a chitosan membrane can increase conductivity. This study aims to determine the lowest resistance value and highest conductivity of solid polymer electrolytes using Li2CO3 from used batteries. After separating the Lithium-Cobalt component from the used battery, it was extracted with deep DES solvent and precipitated using Na2CO3 to produce the Li2CO3 compound. Polymer electrolyte was synthesized by mixing polyvinyl alcohol and adding 0.2 grams, 0.4 grams, 0.6 grams, 0.8 grams, and 1 gram of chitosan. Li2CO3 variables are 0.2 grams, 0.4 grams, 0.6 grams, 0.8 grams, and 1 gram. The results showed that the higher content of chitosan and Li2CO3 led to an increase in ionic conductivity. These results concluded that the best solid electrolyte membrane was obtained with a variation ratio of 0.2 grams of chitosan with the addition of 1 gram of Li2CO3.
Degradation of Aniline & Para- Chloroaniline from Water by Adsorption Coupled with Electrochemical Regeneration
Authors: Hussain Syed muhammad Shahid , Hussain Syed Nadir , Asghar Hafiz Muhammad Anwaar , Sattar Hamed
Published: August 2023

Treatment methods for water-containing organics are gaining significant attraction in modern-day research. Amines are an important organic compound class encountered in industrial wastewater streams. The current research paper focuses on studying the adsorption behavior of aniline and parachloro-aniline using a graphite-based adsorbent, namely, Nyex-1000, and the subsequent regeneration of the adsorbent.   To determine Nyex-1000's adsorption capacity, several parameters, including time, pH, and concentration, were assessed. Adsorption isotherms, kinetics, and used adsorbent regeneration were also investigated. The adsorption of aniline and parachloro-aniline was found to be quite rapid owing to its non-porous nature. Moreover, the low energy requirement makes the process quite economical due to the high electrical conductivity of the adsorbent. The adsorption data was fitted to Langmuir, Freundlich, Redlich Peterson, Sips, and Toth isotherm models. In aniline’s case, Langmuir and Parachloro-aniline Sips models gave the best fitting with the highest R2 value.  A regeneration efficiency of 100% was observed in case of both aniline and parachloro-aniline by passing a charge of 5 and 10 coulombs per gram through the adsorbent bed 10 mm in thickness. Adsorption for parachloro-aniline  was found to be 0.88 mg/g, and for aniline was found to be 0.40 mg/g. The reduction in adsorption capacity was minimal after several adsorption and regeneration cycles. This study found that spent adsorbent could be regenerated effectively through electrochemical regeneration.
Prevalence and Predictors of Cyberbullying in Middle and High School Students During the COVID-19 Pandemic
Authors: Borualogo Ihsana Sabriani , Wahyudi Hedi , Kusdiyati Sulisworo
Published: August 2023

Schools were closed during the COVID-19 pandemic, and the learning process has changed dramatically. Students spent countless hours online for learning and leisure activities and risked themselves by engaging in cyberbullying. This study aims are twofold: (1) to investigate the prevalence of cyberbullying perpetration and victimization during the COVID-19 pandemic, and (2) to investigate predictors of cyberbullying perpetration and victimization. A cross-sectional survey method was used in this study. This study used three questionnaires named Cyberbullying Perpetration and Victimization, Problematic Internet Use Questionnaire Short Form (PIUQ-SF-6), and Cyberbullying Attitudes Measure. Participants are middle and high school students (N = 3,752; 52.4% were girls, 81.6% were middle school students). Data were analyzed using descriptive statistics and multivariate linear regression. Results showed that more students engaged in cyberbullying victimization than perpetration. Boys were more likely to engage in cyberbullying perpetration. Girls were more likely to engage in cyberbullying victimization. The most prevalent cyberbullying perpetration and victimization were posted mean or hurtful comments online. PIU, particularly more time spent online, harms both perpetrators and victims, as many as 3.4% for perpetrators and 4.5% for victims. Having fun teasing others online and feeling good attacking others online made the highest contributions to engaging in cyberbullying perpetration, as many as 10.9% and 10.1%, respectively. Do not accept harming others online and do not feel-good attacking others online, protecting the individuals from being cyberbullied as many as 4.2%. The attitude that school rules will be ineffective at stopping cyberbullying made the highest contribution to being cyberbullied, as many as 4.2%.
Empathy as Mediator in Relationship between Self-Compassion and Prosocial Behavior among Adolescents
Authors: Widyastuti Asri , Savitri Luh Surini Yulia
Published: August 2023

As a construct which promotes having compassion for ourselves, self-compassion has been found to have an inconsistent relationship with prosocial behaviour. However, the relationship between self-compassion and prosocial behaviour might be mediated by another predictor, such as empathy. The lack of literature discussing self-compassion in adolescents also encouraged this research. In this study, we examine the mechanism between self-compassion and prosocial behaviour through empathy as a possible mediating factor. Participants of this study were 303 adolescents in Indonesia aged 11-18 years old who filled out Self-Compassion Scale, Basic Empathy Scale and Prosocial Tendencies Measure-Revised. All the data were analyzed using the mediation analysis using approach introduced by Hayes. The results of statistical analysis showed there was a direct significant effect of self-compassionon prosocial behaviour (c = 0.10, p<0.05), and there was no significant effect from self-compassionon empathy (b=0.04, 95% CI [-0.030, 0.101]). Therefore, there was no indirect effect from self-compassionto prosocial behaviour through empathy. It can be concluded that empathy is not a mediator in the relationship between self-compassion and prosocial behaviour in adolescents.
Forgiveness as a Moderator between Perceived Unfair Treatment and Anger With own Children
Authors: Dumondor Claudia Maria , Tjipto Susana
Published: August 2023

Referring to Komisi Perlindungan Anak Indonesia (KPAI), the highest perpetrators in family violence were mothers (22%), but there has not been much research on the violence transmission from parents to children and the role of forgiveness as a protective factor. This study aims to examine the role of forgiveness as a moderator of the relationship between the perceived unfair treatment by family members of origin and anger with their own children. Participants involved in this study were 63 mothers who perceived unfair treatment by family members of origin and had children aged between 2 to 7 years old. Data were collected using 3 scales: Personal Forgiveness Scale, Family of Origin Hurt Scale, and Attitude toward Child Scale. The multiple regression analysis showed that there was a significant positive relationship between the perceived unfair treatment and anger with one's own child (gender similarity transmission sample, r = .75, p = .000,n = 31; all sample, r = .77, p = .000, n = 63). The analysis for gender similarity transmission sample showed that 56.7% (and for all samples, 58.4) of the variance in anger with one's own child was explained by the perceived unfair treatment by the mother. Meanwhile, forgiveness does not play as a moderator variable in the association of both variables. The implications of the results of this study are discussed.
Melanoma Espial Employing Deep Learning Applied to Mobilenet
Authors: Mukherjee Nivedeeta , Dolzake Nutan , Ubhare Harshal , Sahu Sudeep , Sharma Shubham , Shirdhankar Shreyas
Published: August 2023

Abstract: The most recent advancements in smartphone-based skin cancer diagnosis software enable convenient, portable methods for melanoma risk assessment and diagnosis for skin cancer early detection due to the issue of trade-offs. [12] The majority of skin cancer detection applications do the image analysis on the server due to the (time complexity and error rate) limitations of running a machine learning algorithm for image analysis on a smartphone. In this work, we use the MobileNet v2 deep learning model to examine the performance of skin cancer picture identification and classification on Android devices. [10] We evaluate the effectiveness of a number of factors, including parameter setup, picture acquisition technique, computer and Android-based image analysis, and object identification and classification methods. Melanoma and skin cancer are utilized to evaluate the effectiveness of the suggested approach. [15] The measurement uses the testing techniques' running times, sensitivity, accuracy, and specificity. The optimum parameter for the MobileNet v2 model on Android utilizing photos from the smartphone camera gives 91.346% accuracy for classification, according to the experiment's findings. The Android app's ability to recognize objects and classify them made it possible to analyze skin cancer. Android-based image analysis maintains the computation time threshold that indicates user comfort and matches the computer's performance accuracy for high-quality photos. [18] These results drove the creation of an Android app for disease detection processing that makes use of the camera on smartphones and seeks to achieve high-accuracy real-time detection and classification.
Trust in management, change resistance and work engagement on startup employees in Indonesia
Authors: Aziza Dhimas Fachri , Nadia Fiona Niska Dinda
Published: August 2023

Dynamic industrial development requires many organizations to have the right competitive business strategy. Indonesian startups are no exception. Startups must think about ways to develop their human resources. In addition, because startups are companies that have just grown, startup owners need to build trust in their members to achieve what is planned according to the company’s targets. This study will examine the role of trust in management on work engagement among startup employees in Indonesia, focusing on mediating change resistance. The participants actively involved in this study were 100 start-up members at the staff to middle manager level and were selected based on a purposive sampling technique. The instruments used are the change resistance scale, the trust in management scale, and the work engagement scale. The PLS-SEM method test results found a significant positive role for trust in management on work engagement; trust in management affects change resistance, and change resistance affects work engagement. This means that trust in management can further strengthen its role in increasing work engagement if it is mediated by change resistance.
VISITANDO GALPONES DE ESQUILA. VIAJE DE UN MANAGER DE ESTANCIA POR FUEGOPATAGONIA, 1915
Authors:   Escuela de Arquitectura, Departamento de Obras Civiles, Centro de Innovación de Ingeniería Aplicada (CIIA), Facultad de Ciencias de la Ingeniería, Universidad Católica del Maule, García Oteíza Samuel Alejandro , Bascopé Julio Joaquín ,   Escuela de Arquitectura, Departamento de Obras Civiles, Centro de Innovación de Ingeniería Aplicada (CIIA), Facultad de Ciencias de la Ingeniería, Universidad Católica del Maule, López-Olivari Christian ,   Escuela de Arquitectura, Departamento de Obras Civiles, Centro de Innovación de Ingeniería Aplicada (CIIA), Facultad de Ciencias de la Ingeniería, Universidad Católica del Maule
Published: August 2023

A continuación, se desclasifica un documento que derivó en un hallazgo en terreno. Se trata del diario de viaje de un ovejero que condujo al hallazgo de un galpón de esquila armado, desarmado y trasladado por el Territorio de Magallanes. Este galpón perteneció originalmente a la estancia Kimire Aike, pero hace décadas cambió su ubicación original. Al no existir un factor que gatillara su búsqueda, resultaba insospechado su destino y su posición actual. El galpón en cuestión tiene una cualidad característica de la región fuegopatagónica1 y de otras regiones subpolares: es una estación móvil, kohwi o kau de fierro
The Environment in the Box of Cold-War Developmentalism: North Korea’s 1970s Discourse on Pollution (konghae)
Authors: Cho Eunsung
Published: August 2023

This paper examines the unfolding of North Korean discourse on “konghae (pollution)” in the context of the Cold War and developmentalism during the 1970s. Scrutinizing how the North Korean regime justified its own environmental management approach by critiquing the handling of the konghae issue in capitalist states, this study elucidates the impact of North Korea’s Cold War framing on the intertwined dynamics of development and the environment. In particular, the import of Japanese polluting industries into South Korea triggered the introduction of the term konghae into the North Korean vernacular and the subsequent proliferation of related discourse, which may have also been influenced by the growing global consciousness of environmental matters and the corresponding dialogue on potential solutions.
While Cold War framing impeded North Korean acknowledgment of its own developing pollution problem, discourse on pollution expanded as it became harder to ignore the growing phenomenon of pollution within the country and awareness of pollution became more common. This led to efforts in the 1980s and 1990s to respond to environmental concerns in North Korea, such as the enactment of the Environmental Protection Law in 1986 and the incorporation of environmental rights into the Constitution in 1992. This paper highlights the significance of the 1970s as a pivotal pre-transition phase during which North Korea’s environmental discourse evolved from a confined focus on konghae to a broader, more comprehensive conception of the environment. Despite this progression, the developmentalist idea that technological advancement can resolve environmental challenges persists in the DPRK.
Calidad fisicoquímica y microbiológica del agua costera en Nicoya, Costa Rica: comparación de tres playas con diferente impacto turístico y administración
Authors: Montiel-Mora José R. , Gómez-Ramirez Eddy
Published: August 2023

Introducción: El crecimiento socioeconómico ha causado presión sobre los ecosistemas marinos, y existe poca información que pueda ser utilizada para el manejo de playas en Nicoya, Costa Rica. Objetivo: Determinar la calidad fisicoquímica y microbiológica del agua marino-costera en Nicoya, Costa Rica. Métodos: En octubre de 2021, y mayo y junio de 2022, usamos métodos estándar para evaluar las condiciones fisicoquímicas y microbiológicas del agua, en tres playas con diferentes administraciones y número de turistas. Resultados: La temperatura del agua osciló entre 26,1°C y 31,2°C, la salinidad entre 22 y 31ups, el oxígeno disuelto entre 3,6 y 7,3mg/L y los valores de hidrocarburos totales suspendidos estuvieron por debajo del límite de detección. La mayor contaminación fecal se encontró en época de lluvias, con valores máximos de 3,5x103 NMP/100mL coliformes fecales, 1,1x103 NMP/100mL Escherichia coli y 2,4x103 NMP/100mL Enteroccocus faecalis. Conclusión: Si bien la contaminación fecal fue alta durante la época de lluvias, los parámetros fisicoquímicos fueron aceptables en las tres playas.
Surgical Management of Residual or Recurred Hibernoma of the Neck
Authors: Kim Young Chul , Koh Jiwon , Kwon Seong Keun
Published: August 2023

A 16-year-old girl was incidentally found to have a mediastinal lipogenic mass, which was confirmed as a hibernoma on biopsy. Mediastinal mass excision with full sternotomy was performed, and follow-up chest computed tomography at postoperative 1 year revealed a residual or recurred mass at the left neck (level VI). Consequently, left level-VI neck dissection was performed, and the biopsy also confirmed hibernoma. During neck dissection, an electromyography tube was used to monitor the recurrent laryngeal nerve, and complete removal was achieved without damage to the vagus nerve, carotid vessels, or thyroid gland. When managing cervical lipogenic tumors, clinical suspicion is necessary, followed by radiological and pathological evaluations to differentiate malignancies. If a hibernoma is suspected, en bloc resection of the tumor is crucial to prevent hemorrhage and recurrence. Cervical hibernoma can cause symptoms such as dysphagia, weight loss, and exertional dyspnea owing to its mass effect. Surgeons should be cautious during tumor removal to protect the recurrent laryngeal nerve. We successfully removed the residual or recurred hibernoma in the neck without complications.
Observaciones sobre la evaluación formativa en docentes de la Escuela de Ciencias de la Educación - ZCBOY UNAD
Authors: Medina Pedraza Edgar Crisanto , Rozo Suárez Juana Valentina
Published: August 2023

La observación de las prácticas de evaluación formativa permite un proceso de reflexión para así detectar espacios de mejora. Hacer un diagnóstico inicial del uso y apropiación de la evaluación formativa en algunos docentes se configura como el objetivo principal de la aplicación de un instrumento de medición. De esta manera, desde la Escuela de Ciencias de la Educación de la Universidad Nacional Abierta y a Distancia UNAD - Zona Centro Boyacá ZCBOY – Colombia, se ha implementado un instrumento inspirado y creado por el Centro Universitario, CIFE, de México, que permite evaluar y observar los procesos de la evaluación formativa aplicada por los docentes. A partir de la aplicación de dicho instrumento se logra evidenciar que hay avances en la evaluación formativa, pero que también existen áreas de oportunidad para mejorar la aplicación de dichos procesos. Las principales áreas de oportunidad se ven representadas en la corrección con base al seguimiento, los procesos de autoevaluación de los docentes, formación de estos y el incremento de las asesorías y seguimiento permanente a los estudiantes. Dentro de las conclusiones más relevantes se encuentra que es esencial mantener el proceso de observación de las prácticas de evaluación formativa y su implementación para así mejorar el proceso desde la práctica docente.
Fortalecimiento de las lenguas indígenas en Colombia
Authors: Mojica Sauna Armando , Contreras Griego Isaac Rafael , Duarte Orozco Mario Alejandro
Published: August 2023

La lengua materna es el elemento constitutivo fundamental dentro de las culturas indígenas, porque permite la conservación de la identidad y los valores ancestrales. Este artículo busca describir las principales estrategias, recursos y políticas en educación que se han desarrollado en Colombia, enfocadas al fortalecimiento de las lenguas maternas indígenas entre los años 2017 al 2021. Se desarrolla a través de la metodología cualitativa descriptiva, una revisión y análisis documental de artículos científicos, tesis de maestría y doctorados de investigaciones realizadas en el país, con el fin de recopilar aportes principales de autores en cuanto la implementación de estrategias etnoeducativas y políticas lingüísticas que permitan fortalecer las lenguas originarias. Los resultados se exponen a través de tres categorías principales apoyados en diferentes investigaciones y autores con enfoques dirigidos principalmente al fortalecimiento de las lenguas indígenas y sus contribuciones se centran en el desarrollo de competencias interculturales y sociolingüísticas en entornos educativos. Al final se tienen en cuenta algunos aspectos más relevantes como los hallazgos, las discusiones y comparaciones de los diferentes aportes teóricos; y, por último, en la conclusión se tendrá en cuenta algunas consideraciones del tema de la revisión, principalmente encontrados en relación con las dificultades y avances surgidos en el transcurso de las investigaciones.
Impact of Arteriovenous Fistula on Flow States in the Evaluation of Aortic Stenosis among ESKD Patients on Dialysis
Authors: Ogugua Fredrick , O Roy Mathew , Ternacle Julien , Rodin Holly , Pibarot Philippe , Shroff Gautam
Published: August 2023

Introduction An arteriovenous fistula (AVF) in patients with
end-stage kidney disease (ESKD) can influence flow states. We sought to
evaluate if assessment of aortic stenosis (AS) by transthoracic
echocardiographic (TTE) differs in the presence of AVF compared to other
dialysis accesses in patients on dialysis. Methods We
identified consecutive ESKD patients on dialysis and concomitant AS from
a single center between January 2000 and March 2021. We analyzed TTE
parameters of AS severity (velocities, gradients, aortic valve area
[AVA]) and hemodynamics (cardiac output [CO], valvuloarterial
impedance [Zva]) and compared AS parameters in patients with AVF
versus other dialysis access. Results The cohort included 94
patients with co-prevalent ESKD and AS; mean age 66 years, 71% male;
43% Black, 24% severe AS. Dialysis access: 53% AVF, 47% others. In
the overall cohort, no significant differences were noted between AVF
vs. non-AVF in AVA/CO/Zva, but with notable subgroup differences. In
mild AS, CO was significantly higher in AVF vs. non-AVF (6.3 vs. 5.2
L/min; p=0.04). In severe AS, Zva was higher in the AVF vs. non-AVF (4.6
vs. 3.6 mmHg/ml/m ). With increasing AS severity in
the AVF group, CO decreased, coupled with increase in Zva, likely
counterbalancing the net hemodynamic impact of the AVF.
Conclusion Among ESKD patients with AS, TTE parameters of flow
states and AS severity differed in those with AVF versus other dialysis
accesses and varied with progression in severity of AS. Future
longitudinal assessment of hemodynamic parameters in a larger cohort of
co-prevalent ESRD and AS would be valuable.
The influence of moisture content on drilled cuttings’ properties of bed packing and flowability
Authors: Altino Heitor , Lourenço Giovani , Ataíde Carlos , Duarte Claudio
Published: August 2023

To design and operate various equipment of the solids control system in offshore drilling platforms, it is important to establish how the moisture content influences the characteristics of drilled cuttings to form packed beds and flow over solid surfaces. The current study comprehensively analyzes how moisture content, primarily composed of water and representing water-based muds (WBMs), influences the bed packing properties and drilled cuttings' flowability. The particle aggregation/disaggregation dynamics, loose and tapped bulk densities and porosities, compaction dynamics of packed beds, Hausner ratio, and angle of repose of drilled cuttings with ten distinct moisture contents (1.4?44.0 wt%) were analyzed. It was noticed that the increment of moisture content up to 15.2% promoted the formation of looser interparticle structures. However, these structures were steadier, showing greater difficulty flowing and releasing air/liquid. The continuous increment of moisture content beyond 15.2% promoted a complete change in the material behavior. The interparticle structures became denser. The material could flow and release air/liquid more easily. In addition, it was possible to establish a classification of the different behaviors of drilled cuttings according to the moisture content. Predictive models were proposed to describe the influence of the moisture content on the bed packing and flowability properties of drilled cuttings.
Insulin sensitivity and C-reactive protein levels after laparoscopic and open cholecystectomy - seven days follow-up
Authors: Micic Dusan , Polovina Snezana , Loncar Zlatibor , Doklestic Krstina , Gregoric Pavle , Arsenijevic Vladimir , Ceranic Miljan , Micic Dragan , Ivancevic Nenad
Published: August 2023

Introduction/Objective. The development of acute insulin resistance after surgery intervention is associated with the type and magnitude of operation and tissue injury. The aim of our study was to compare insulin sensitivity assessed by homeostatic model assessment of insulin resistance (HOMA-IR) and C-reactive protein (CRP) before and after laparoscopic and open cholecystectomy during seven days follow-up. Methods. In total, 92 patients were divided into two groups: laparoscopic cholecystectomy (Group 1) (n = 61) and open cholecystectomy (Group 2) (n = 31). Glucose, insulin and CRP levels were measured at day 0 and at postoperative days one, three and seven. Glucose, insulin and CRP were determined using commercial assay on Roche Cobas 6000 automated analyzer (Roche Diagnostics, Manheim, Germany). Results. There was no statistical difference between studied groups concerning age (p = 0.626), body mass index (p = 0.548), glucose (p = 0.947), insulin (p = 0.212), HOMA-IR (p = 0.390) and CRP (p = 0.546) at day 0. At day one, higher values of CRP were found in group 2 compared with group 1 (p = 0.046). At day three, significantly higher values of glucose and HOMA-IR were found in group 2 compared with group 1 (p = 0.025, p = 0.036, respectively). Conclusion. Increase in CRP precedes deterioration of insulin sensitivity measured by HOMA-IR after cholecystectomy. Impairment of insulin sensitivity was more pronounced at postoperative day three in group with open cholecystectomy. On the basis of our results, laparoscopic cholecystectomy induced less impairment in insulin sensitivity and lower inflammatory response.
Índices de Naturaleza Urbana: marco metodológico e indicadores clave
Authors:   IUCN, International Union for Conservation of Nature
Published: August 2023

La Alianza Urbana de la UICN, una amplia coalición de Miembros de la UICN preocupados por las dimensiones urbanas de la conservación de la naturaleza, ha presentado un nuevo producto de conocimiento para medir el desempeño ecológico de las ciudades: los Índices de Naturaleza Urbana (INU) de la UICN. El INU, compuesto por seis temas con cinco temáticas anidadas en cada tema, una para cada indicador, pretende ayudar a los responsables de la formulación de políticas, a las partes interesadas y a las comunidades locales a comprender su impacto en la naturaleza, establecer objetivos de mejora basados en la ciencia y supervisar los avances utilizando, también, medidas basadas en la ciencia. Al aumentar la transparencia y la responsabilidad medioambientales, y al centrarse en la mejora más que en metas fijas, el INU busca catalizar la acción local en favor de la naturaleza en todas las ciudades.
Impact of Gestational Diabetes Detection Thresholds on Infant Growth and Body Composition: A Prospective Cohort Study Within a Randomized Trial
Authors: Manerkar Komal , Crowther Caroline A. , Harding Jane E. , Meyer Michael P. , Conlon Cathryn A. , Rush Elaine C. , Alsweiler Jane M. , McCowan Lesley M.E. , Rowan Janet A. , Edlin Richard , Amitrano Francesca , McKinlay Christopher J.D.
Published: August 2023

OBJECTIVE

Gestational diabetes mellitus (GDM) is associated with offspring metabolic disease, including childhood obesity, but causal mediators remain to be established. We assessed the impact of lower versus higher thresholds for detection and treatment of GDM on infant risk factors for obesity, including body composition, growth, nutrition, and appetite.

RESEARCH DESIGN AND METHODS

In this prospective cohort study within the Gestational Diabetes Mellitus Trial of Diagnostic Detection Thresholds (GEMS), pregnant women were randomly allocated to detection of GDM using the lower criteria of the International Association of Diabetes and Pregnancy Study Groups or higher New Zealand criteria (ACTRN12615000290594). Randomly selected control infants of women without GDM were compared with infants exposed to A) GDM by lower but not higher criteria, with usual treatment for diabetes in pregnancy; B) GDM by lower but not higher criteria, untreated; or C) GDM by higher criteria, treated. The primary outcome was whole-body fat mass at 5–6 months.

RESULTS

There were 760 infants enrolled, and 432 were assessed for the primary outcome. Fat mass was not significantly different between control infants (2.05 kg) and exposure groups: A) GDM by lower but not higher criteria, treated (1.96 kg), adjusted mean difference (aMD) −0.09 (95% CI −0.29, 0.10); B) GDM by lower but not higher criteria, untreated (1.94 kg), aMD −0.15 (95% CI −0.35, 0.06); and C) GDM detected and treated using higher thresholds (1.87 kg), aMD −0.17 (95% CI −0.37, 0.03).

CONCLUSIONS

GDM detected using lower but not higher criteria, was not associated with increased infant fat mass at 5–6 months, regardless of maternal treatment. GDM detected and treated using higher thresholds was also not associated with increased fat mass at 5–6 months.
Methyl Donor Nutrient Intake and Incidence of Type 2 Diabetes: Results From Three Large U.S. Cohorts
Authors: Sawicki Caleigh M. , Haslam Danielle E. , Braun Kim V.E. , Drouin-Chartier Jean-Philippe , Voortman Trudy , Franco Oscar H. , Sun Qi , Hu Frank B. , Bhupathiraju Shilpa N.
Published: August 2023

OBJECTIVE

We examined whether intake of methyl donor nutrients, including vitamins B2, B6, and B12 and folate, from foods and/or supplements is associated with type 2 diabetes risk.

RESEARCH DESIGN AND METHODS

We included 203,644 women and men from the Nurses’ Health Study (1984–2016), Nurses’ Health Study 2 (1991–2017), and Health Professionals Follow-Up Study (1986–2016). Dietary data were collected every 2–4 years with use of semiquantitative food-frequency questionnaires. Cox proportional hazards models with time-varying covariates were used to evaluate associations between each nutrient and type 2 diabetes risk. We combined cohort-specific hazard ratios (HRs) using inverse variance–weighted fixed-effects meta-analyses.

RESULTS

During 4,900,181 person-years of follow-up, we documented 19,475 incident type 2 diabetes cases. In multivariable-adjusted meta-analyses, participants in the highest quintiles of total vitamin B2 and B6 intakes had lower risk of diabetes compared with those in the lowest quintiles (HR 0.93 [95% CI 0.89, 0.98] for B2 and 0.93 [0.89, 0.97] for B6). With stratification by source, significant associations remained for B2 from food but not from supplements. Neither association for B6 from food nor association for B6 from supplements attained significance. No association was observed between total B12 intake and diabetes. However, B12 from food was marginally associated with higher diabetes risk (1.05 [1.00–1.11]) but not after additional adjustment for red meat intake (1.04 [0.99–1.10]). No evidence of association was observed between intakes of folate and diabetes.

CONCLUSIONS

The results of our study suggest that higher intake of vitamin B2 and B6, especially B2 from food sources, may be associated with a modestly lower type 2 diabetes risk.
Note on psoriasis. Concordance in monozygous twins.
Authors: Bettley FR.
Published: August 2023

No abstract available
Radioactive monitoring of degranulating mast cells.
Authors: Katz HI , Fusaro RM , Smith QT.
Published: August 2023

No abstract available
Systemic effects of topically applied corticosteroid hormones.
Authors: Herdenstam CG.
Published: August 2023

No abstract available
Ultrastructure of mast-cell granules in squamous cell carcinoma.
Authors: Kobayasi T , Asboe-Hansen G.
Published: August 2023

No abstract available
Spectral skin sensitivity in erythropoietic protoporphyria.
Authors: Nozicková-Novotná M , Kraus Z , Janousek V.
Published: August 2023

No abstract available
Wound healing under plastic-coated pads.
Authors: Knudsen EA , Snitker G.
Published: August 2023

No abstract available
Indomethacin in urticaria and histamine induced wealing. A double-blind
Authors: Zachariae H , Niordson AM , Henningsen SJ.
Published: August 2023

No abstract available
Routine patch testing V. Correlations of reactions to the site of dermatitis and
Authors: Magnusson B , Fregert S , Hjorth N , Hovding G , Pirilä V Skog
Published: August 2023

No abstract available
Leg ulcers. A report of two cases caused by sarcoidosis.
Authors: Brodkin RH.
Published: August 2023

No abstract available
The effect of humidity on the phototoxic response to 8-methoxypsoralen in guinea
Authors: Levine GM , Harber LC.
Published: August 2023

No abstract available
Isolation-ward treatment for dermatoses. II. Influence on bacterial colonization
Authors: B Nyström , L Molin , G. Rajka
Published: August 2023

No abstract available
Sj?gren-Larsson syndrome. Diversity of cutaneous manifestations
Authors: LA Goldsmith , HP Baden , TG. Canty
Published: August 2023

No abstract available
Local panatrophy with linear distribution: a clinical, ultrastructural and biochemical study
Authors: Serup J. , Weismann K. , Kobayasi T. , Ammitzbøll T. , Møller R.
Published: August 2023

A young female with local panatrophy of the right-side extremities affecting all mesodermal layers--dermis, subcutaneous tissue, muscles, and bone--is described. The atrophies were strictly linear. Ultrastructurally, collagen fibrils of the reticular dermis from the atrophic area consisted of two types, a large population of fibrils with decreased diameter and round cut-surface, and a small population with increased diameter and a "flower-like" cut-surface. Collagen analysis revealed a reduced hydroxyproline concentration and content per mm2 skin in atrophic area as compared with the perilesional and regional control. Urinary excretion of hydroxyproline was normal. Glycosaminoglycan analysis showed a less reduced content of hexosamine and uronic acid in the atrophic area per mm2 skin, but no differences in the concentrations. Consistently, the gel/fibre ratio (uronic acid/hydroxyproline) was found slightly elevated in atrophic skin. The proportions of the individual glycosaminoglycans heparin, dermatan sulphate, hyaluronic acid and chondroitin sulphates were not affected. It is concluded that reduced collagen and ultrastructural changes of collagen fibrils are significant features in local panatrophy. The significance of local foetal factors affecting the somatic mesoderm is discussed.
Effects of short-wave ultraviolet light (UVB) on delayed hypersensitivity in the guinea pig
Authors: Austad J. , Mørk NJ.
Published: August 2023

Guinea pigs, previously sensitized to dinitrochlorobenzene (DNCB), were exposed to varying doses of UVB radiation on the right flank for a period of 12 days. The response to an elicitation dose of DNCB was diminished in the irradiated skin immediately after UV treatment. This effect was dose-dependent. No reduction in the response could be demonstrated in unexposed skin. One week after UVB treatment the response to DNCB was increased, and after 2 weeks there was a normal eczematous reaction after application of DNCB.
Malignant clear cell hidradenoma: a case report
Authors: Czarnecki DB. , Aarons I. , Dowling JP. , Lauritz B. , Wallis P. , Taft EH.
Published: August 2023

A 73-year-old man developed a malignant clear cell hidradenoma on the nose. Although it was treated solely with diathermy and curettage it did not recur. These rare tumours are histologically malignant but do not always behave aggressively. In some patients local growth and recurrence may occur, while in others the tumour metastasizes widely. There is no way of predicting how these tumours will behave.
Cartilaginous nevus on the glabella
Authors: Sayama S. , Tagami H.
Published: August 2023

Cartilaginous nevus usually occurs in front of the auricle as an accessory auricle and much less frequently on the cheek or anterior part of the neck. We report a case of cartilaginous nevus found on an unusual location, The glabella of the face, in an otherwise normal newborn girl. We think that it was a remnant of the branchial cartilage derived from the first pharyngeal arch of embryonic life.
An immunological study of patients with bullous pemphigoid
Authors: Hovmark A. , Asbrink E.
Published: August 2023

No abstract available.
Cutaneous periarteritis nodosa occurring during pregnancy
Authors: Janin-Mercier A. , Beyvin AJ. , Pablo M. , Jacquetin B.
Published: August 2023

No abstract available.
Forty years of diarrhoea in a patient with urticaria pigmentosa
Authors: Mahood JM. , Harrington CI. , Slater DN. , Corbett CL.
Published: August 2023

A patient with urticaria pigmentosa who gave a 40-year history of diarrhoea was found to have systemic mastocytosis with gut involvement. The radiological appearance of the gut in this disease, although not widely recognized, are specific and should be looked for carefully in patients with urticaria pigmentosa who complain of gastro-intestinal symptoms. Gastro-intestinal symptoms, due mainly to alterations in bowel motility or peptic ulceration, are said to occur in some 25-50% of cases of systemic mastocytosis (3, 6). These symptoms have usually been ascribed to generalized histamine release acting on the gut, although cases where mast cell infiltration of the bowel has occurred have also been reported (4, 5). In a review of the radiological features (2), increased gastric rugosity with or without evidence of peptic ulceration and nodular space-filling defects of the bowel mucosa were the most commonly found. Occasionally, diffuse thickening of the bowel wall was seen. It was concluded that these appearance were probably due to local release of vasoactive substances causing submucosal oedema following mast cell accumulation in the gut. Another result of such infiltration may be malabsorption (1).
Acantholysis induced by proteolytic enzymes. II. Enzyme fractions produced by Trichophyton mentagrophytes
Authors: Hino H. , Ammitzbøll T. , Svejgaard E. , Kobayasi T. , Asboe-Hansen G.
Published: August 2023

Trichophyton mentagrophytes produces three enzyme fractions of molecular weight 65,000, 92,000 and 18,000, respectively. Normal human skin was cultivated and the specimens were subjected to electron microscopy. Enzyme fraction I showed the capacity to induce epidermal acantholysis and dermo-epidermal separation, while the other two fractions showed no proteolytic nor keratinolytic action in cultivated skin.
E-rosette formation of lymphocytes from patients with atopic dermatitis
Authors: Bjerring P. , Thestrup-Pedersen K.
Published: August 2023

The total number of circulating T lymphocytes in 47 patients with atopic dermatitis was a significantly lower than in 98 healthy persons. However, when the T lymphocytes were investigated for their affinity to sheep erythrocytes (E-rosette formation), no difference was found between patients and healthy persons, when using several different techniques varying in length of incubation of sheep erythrocytes and lymphocytes, presence of fetal calf serum, glassware, media, increased mechanical force at resuspension, and different observers. Our findings are discussed with reference to earlier publications of a reduced percentage of E-rosette forming lymphocytes in patients with atopic dermatitis.
PUVA therapy for polymorphous light eruptions: comparison of systemic methoxsalen and topical trioxsalen regimens and evaluation of local protective mechanisms
Authors: Jansén CT. , Karvonen J. , Malmiharju T.
Published: August 2023

Twenty-six patients with long-standing, recurrent polymorphous light eruptions were treated with psoralen photochemotherapy. Thirteen patients received oral methoxsalen, while 13 were photosensitized by trioxsalen baths. After an average of 20 PUVA exposures, a good or excellent therapeutic result was achieved in 12 of the orally treated and 10 of the topically treated patients. In most of the cases, clinical desensitization lasted throughout the summer season, without further PUVA exposures. When the polymorphic phototest reaction (PPR) was registered 72 h after skin testing with a medium pressure mercury lamp, a remarkable reduction or total abolition of the reaction was seen in tests made on PUVA-exposed skin, as compared with tests made on a comparable skin site, shielded from UVA exposure during the treatments. A concomitant decrease in the erythemal reactivity (MED) of the skin was usually--though not invariably--seen. It is concluded that in addition to including an increase in the shielding properties of stratum corneum, PUVA treatment may induce non-responsiveness in PMLE skin by other, possibly anti-inflammatory or immunological mechanisms.
Sézary syndrome: relative increase in T helper lymphocytes demonstrated by monoclonal antibodies
Authors: Thivolet J. , Fulton R. , Souteyrand P. , Gaucherand M. , Claudy A.
Published: August 2023

No abstract available.
Malignant melanoma caused by UV-A suntan bed?
Authors: Brodthagen H.
Published: August 2023

No abstract available.
Endothelial cell renewal in skin of patients with progressive systemic sclerosis (PSS): an in vitro autoradiographic study
Authors: Kazandjian S. , Fiessinger JN. , Camilleri JP. , Dadoune JP. , Housset E.
Published: August 2023

The labelling index of endothelial cells of the dermal microvessels was studied by in vitro autoradiography with [3H] thymidine. 14 patients with PSS were compared with 7 control subjects, by sampling the upper-third of the forearm skin. One patient had a second biopsy in this area, on a telangiectasis. Microvessels from patients showed a significant increase in endothelial cell labelling. Within the PSS group, no difference was found between the indurated and the non-indurated skin. There was no correlation between the labelling index and the duration of the disease. A very high uptake was found in the telangiectasis. Such an increased labelling index in PSS is consistent with a response to the endothelial cell destruction as described in electron microscopy and in cultures with patient´s serum.
Galactose tolerance test and methotrexate-induced liver fibrosis and cirrhosis in patients with psoriasis
Authors: Lenler-Petersen P. , Søgård H. , Thestrup-Pedersen K. , Zachariae H.
Published: August 2023

A total of 151 galactose tolerance tests (GTT) and liver biopsies were performed in a consecutive study of 45 psoriatic patients with methotrexate-induced liver fibrosis; of these, 23 had cirrhosis. Most patients with an abnormal liver histology had a normal GTT. We conclude that an oral GTT is not sensitive enough to reveal methotrexate-induced liver fibrosis or cirrhosis. The results indicate that the histological changes in methotrexate-induced liver fibrosis and cirrhosis may be of a rather non-aggressive nature.
Demodex folliculorum hominis (Simon): incidence in a normomaterial and in patients under systemic treatment with erythromycin or glucocorticoid
Authors: Bøge-Rasmussen T. , Christensen JD. , Gluud B. , Kristensen G. , Norn MS.
Published: August 2023

A study was made of 20 cilia and sebum from 20 nasal follicles from each of 86 persons. In a normomaterial aged 20-30 years. Demodex folliculorum was present in the nasal follicles in 25% and in the cilia in 29% of the subjects. This is consistent with the very high incidence we found 10 years ago. Systemic erythromycin treatment did not erradicate the mite, but the incidence decreased in both regions. Systemic glucocorticoid treatment lowered the incidence in the nasal region, whereas the incidence increased in the ciliary region.
Corneocyte morphology and formation rate in lichen planus and experimental parakeratosis in subjects with and without psoriasis
Authors: Johannesson A. , Hammar H.
Published: August 2023

In a recent paper changes in corneocyte morphology and formation rate in psoriasis have been established. In the present study the specificity of these alternations were analysed in two situations. Early lichen planus papules were chosen as a model of hyperproliferation with hypergranulosis and orthohyperkeratosis. Hyperproliferation with parakeratosis was induced by nonanoic acid (CH3(CH2)7COOH) as an experimental model in psoriatics and non-psoriatics. In lichen planus papules, the rate of corneocyte layer formation was 2.4 times that of the non-involved skin. In psoriasis, a similar rate was found in parts with hypergranulosis. A 13% decrease in corneocyte diameter took place in lichen planus lesions--similar to that found in psoriasis. The corneocytes in lichen planus were also thicker than normal cells, though their volumes were similar. Thickness decreased in more superficial locations of these corneocytes. Swelling was a finding during the histological procedure, Corneocytes in the lesion increased markedly in volume, due to swelling. The parakeratosis elicited by nonanoic acid showed cells with irregular membranes and nuclei with non-flattened and irregular borders. The rate of corneocyte layer formation was 2.6 times that of the normal skin. The epidermal reaction to the superficial damage by nonanoic acid did not differ between psoriatics and non-psoriatics. This type of parakeratosis was distinctly different from that present in psoriasis.
The inhibitory effect of zinc pyrithione on the epidermal proliferation of animal skins
Authors: Imokawa G. , Okamoto K.
Published: August 2023

The hypothesis that zinc pyrithione, a highly active anti-dandruff agent, exerts an anti-biosynthetic effect and reduces the epidermal turnover has been tested using guinea pig and hairless mouse skins. It has been found that enhanced mitosis caused by both stripping off the horny layers and sodium dodecyl sulphate, could be suppressed by approximately 50% by the topical application of zinc pyrithione. Furthermore, sodium dodecyl sulphate-induced epidermal hyperproliferation has been found suppressible by the simultaneous application of zinc pyrithione. Thymidine incorporation studies using hairless mice revealed that a single application of zinc pyrithione results in reduction of DNA synthesis. It is suggested that the anti-dandruff effect of zinc pyrithione results primarily from its action as an anti-biosynthetic agent rather than from its anti-yeast action.
Transfer factor therapy in mycosis fungoides: a double-blind study
Authors: Thestrup-Pedersen K. , Grunnet E. , Zachariae H.
Published: August 2023

Sixteen patients with mycosis fungoides (MF) were given either active transfer factor (TF) or heat-inactivated TF as additional therapy to topical nitrogen mustard or PUVA. The TF was prepared from non-selected healthy blood donors. The clinical evaluation after 2 years of therapy showed that among 8 patients treated with active TF, none went into complete remission of their disease 4 patients had partial remission, one was unchanged, 2 progressed, and one died of active MF. In the placebo-treated group, 5 patients achieved complete remission and 2 partial remission. One patient died early in the trial due to cardiac disease. Immunological studies during the first year of therapy revealed cutaneous anergy towards tuberculin in most patients. This anergy did not change during TF therapy and differed from normal lymphocyte reactivity in vitro after tuberculin stimulation. At the start of treatment the patients had diminished levels of T lymphocytes in peripheral blood. A temporary increase was observed in the total number of T lymphocytes in patients after one month of treatment with active TF. After one year the T lymphopenia had disappeared in both groups. The mitogen reactivity of lymphocytes was found to be normal (PHA, PWM) or somewhat reduced (Con A). It is concluded that under the conditions employed in this trial, TF was not able to prevent progression of early mycosis fungoides, when viewed over a period of 2 years.
Transient lymphomatoid papulosis in mycosis fungoides
Authors: Aronsson A. , Jonsson N. , Tegner E.
Published: August 2023

During PUVA treatment a 66-year-old woman with mycosis fungoides in stage III suddenly developed widespread papulonodular lesions of alarming clinical and histological appearance. There was rapid spontaneous and complete regression of the eruptions, which was probably an expression of transient lymphomatoid papulosis in connection with MF.