bluuebunny/crossref_metadata_2025 huggingface dataset:
Layout modelling of the built environment for autonomous mobile robots using Building Information Modelling (BIM) and simulation
Authors: Byers Gareth , RazaviAlavi SeyedReza
Published: September 2022

Robotics is a fast-growing technology in the construction industry, particularly in off-site construction and Modern Methods of Construction (MMC). Recent advancements in technologies have made robots more intelligent and capable of autonomously undertaking tasks. Navigation of the robots in the built environment requires analysis of robots’ sensor data, which is computationally sophisticated and time consuming. Modeling the layout of the built environment using BIM and simulation can reduce the computational burden of the sensor data analysis. This research aims to develop a method to transfer the geometry data from BIM models to virtual robots in the simulation environment, and provide the robots with priori knowledge about the built environment. This method is simple-to-use and can enhance robot navigation in terms of accuracy and efficiency. The method was implemented in a case study to demonstrate its usefulness and practicality.
An holistic approach to product evaluation and selection in industrialised building: Benchmarking of long span, low carbon floor systems
Authors: Kuzmanovska Ivana , Bunster Victor , Solarte Angela , Maxwell Duncan
Published: September 2022

As the construction industry shifts towards more systematised methods of designing and delivering buildings, data-informed approaches towards product development, evaluation, and selection promise to enable improved performance (structural, acoustic, fire, environmental), material efficiencies, and ease of production while maintaining the highest quality end result. This paper presents the outcomes of an applied research project that takes the first steps towards the development of a framework to guide holistic evaluation of product performance and future design efforts. Key outcomes of the research include: a systems matrix approach to (1) map the current product landscape, (2) select representative systems for benchmarking, and (3) to communicate relative performance; and a decision matrix used to illustrate the effect of varying priorities when selecting products for use in a building project.
Operations management concepts applied to offsite construction
Authors: Prado Lujan Guillermo
Published: September 2022

The Architecture Engineering and Construction (AEC) industry has been criticized for low productivity, lack of innovations, damage to the environment, lack of improvement. Several innovations have emerged to address these problems and, in this paper, the relationship between operations management (OM) and offsite construction will be discussed. The purpose of this paper is to present a proposal for the application of OM concepts in offsite construction. A research method based on the assumption that construction processes can be analyzed as production systems will be used. The resulting proposal consists of the exploration of potential applications, benefits, and barriers of OM in offsite construction based on the current experience of OM in manufacturing processes. A thorough discussion about the implications of this proposal in a project and supply chain levels are presented. The most important conclusions were related to the need for applying OM concepts in offsite construction projects and the need for more research in this direction to prove the proposed proposal.
Front matter, 2022 Proceedings of the Modular and Offsite Construction Summit
Authors: Al-Hussein Mohamed
Published: September 2022

Proceedings of the 2022 Modular and Offsite Construction (MOC) SummitEdmonton, Alberta, CanadaJuly 27 - 29, 2022

Editor(s): Dr. Mohamed Al-Hussein, PhD, University of Alberta© University of Alberta Library, Edmonton, CanadaISSN 2562-5438
Pengenalan dan Edukasi Senam Jantung Sehat Di Poli Jantung Pada Era Pandemi Covid-19 di Rumah Sakit Akademik Universitas Mataram
Authors: Meiswaryasti P Anak Agung Sagung Mas , Budyono Catarina , Lestarini Ima Arum , Putri Novia Andansari , Wedayani Niti , Partiwi Sekar
Published: September 2022

Heart disease is included in the list of diseases that cause the most deaths in Indonesia. Starting from a heart attack, coronary heart disease, heart failure to cardiac arrest. All these diseases are closely related to the application of an unhealthy lifestyle, one of which is lazy to move. Healthy heart exercise is the most popular choice of exercise in the community. This exercise is composed of various movements that benefit the heart. Starting from strengthening the heart muscle, preventing damage to the arteries due to high cholesterol, lowering high blood pressure, and keeping weight under control. Health workers play an important role in providing education related to the health of the people of West Nusa Tenggara. Lack of public knowledge about one way to prevent coronary heart disease is the responsibility of health workers to provide education. Because the lack of knowledge to prevent it causes an increase in morbidity and mortality caused by heart disease. The approach steps taken in this program are counseling or providing education to visitors to the Cardiology Polyclinic at the Mataram University Hospital. Community service was carried out at the Poly Hospital of UNRAM and also in the hall of the UNRAM Hospital. Attended by 30 participants and 1 speaker as well as 4 young doctors and 1 lab employee from the Faculty of Medicine, University of Mataram. From the analysis of the questionnaire distributed, 28 people scored less than 50 in answering questions about risk factors and the dangers of obesity and there was a change in the score to 26 respondents who got a score of 80 after being given education. This shows that after the education is given, public knowledge about cardiac gymnastics increases.
The COVID-19 pandemic as a consequence of sustainable changes in the planet’s biosphere
Authors: Stupakov G. P. , Shcherbinina N. V. , Shirokov E. A.
Published: September 2022

The pandemic caused by the SARS-CoV-2 virus has demonstrated the development of new global biological, biophysical and epidemiological processes able to change human environment and cause signifi cant demographic, social and economic consequences. The explanation of the pandemic as caused by accidental transmission of the virus from animal to human does not seem convincing and does not correspond to the scale of the planetary biological shifts that have occurred as a result of the pandemic. The authors of the article develop a hypothesis that links the causes of the COVID-19 pandemic with global environmental problems and damages of the biocoenosis of large ecosystems on the planet. The disastrous reduction of forest areas throughout the continents has led to a growing disproportion of the plant kingdom, animals and the expansion of viruses in biosphere. The mechanism of viral infections propagation has changed under conditions of violation of the stability of the biocoenosis and the fi lling of large ecosystems with viruses. Along with the traditional methods of infection transmission from person to person, the physical features of viruses and their correlations to the nanoworld have become signifi cantly important. Literature data and the results of our own research suggest that viruses have wave properties and are capable of creating stable resonance systems and an electromagnetic fi eld. Presumably, the energy of the electromagnetic fi eld determines the mechanism for filling ecosystems with viruses, “competitive relations” with other representatives of the microcosm, and the process of self-limitation of viral expansion. The article for the first time touches upon the issues of the interaction of viruses within the framework of viral and viral-bacterial microbiocenosis, the persistence of viruses in the human body and the development of chronic diseases. The study of the mechanisms of virus expansion, the patterns of emergence and contagion suggests newopportunities for understanding the nature of new viral infections and the development of methods to resist them.
The effectiveness of melatonin in coronary heart disease
Authors: Zaslavskaya R. M.
Published: September 2022

The article is dedicated to a review of the literature on the use of melatonin in patients with coronary artery disease, taking into account its participation in the regulation of the cardiovascular system, the function in the presence of a circadian rhythm of hemodynamic parameters and melatonin receptors in the muscular layer and endothelial tissue. The eff ect of melatonin on the organs of the cardiovascular system is due to its pronounced antioxidant activity, and the ability to infl uence vascular tone, heart rate, and inhibit platelet aggregation.
Enhancement the eff ec- tiveness of therapy of the new COVID-19 coronavirus infection using interferon alpha-2b in adults
Authors: Mordyk A. V. , Vyzhlova E. N. , Samsonov K. Yu. , Zenkova L. A. , Ptukhin A. O. , Kukhlov V. V. , Semenenko T. A. , Shuvalov A. N. , Bragina G. S.
Published: September 2022

In order to assess the clinical eff ectiveness of COVID-19 complex therapy in adults, 140 patients with a confi rmed diagnosis of a new coronavirus infection, clinical symptoms and lung damage from 25 to 75 % (mild and moderate form) hospitalized in budgetary healthcare institutions of the Omsk region were included in an open prospective observational study. Patients were evenly divided into two groups: 1 — received standard therapy in accordance with the Temporary Guidelines "Prevention, diagnosis and treatment of new coronavirus infection (COVID-19)" approved by the Ministry of Health of the Russian Federation and interferon alpha-2b preparations (Viferon ® rectal suppositories 3,000,000 IU and Viferon ® gel for external and topical use of 36,000 IU/g); 2 — received only standard therapy. In group 1 patients, elimination of the SARS-CoV-2 antigen from the nasopharyngeal mucosa occurred 2 days earlier than in group 2 patients. Also, patients receiving standard therapy and interferon alpha-2b preparations improved on average 4.5 days earlier, most of the main symptoms of the disease were stopped by the 6th day of therapy. It was noted that in patients receiving complex standard therapy with adding of interferon alpha-2b preparations, a more pronounced regression of lung tissue damage was observed, especially in patients with a high degree of their lesion according to CT data before hospitalization. By the end of treatment in group 1, the proportion of patients with lung tissue lesions of grade CT-3 signifi cantly decreased by 17%, while in group 2, the proportion of patients with CT-3 increased by 13 %. Analysis of the dynamics of laboratory parameters and the main markers of infl ammation in the therapy groups also confi rms the positive eff ect of the inclusion of interferon alpha-2b drugs in the standard therapy. No adverse events associated with the use of interferon alpha-2b preparations were registered. Thus, in patients receiving standard therapy and interferon alpha-2b preparations, recovery occurred in a shorter time. In the end, this contributed to a faster discharge from the hospital and a reduction in the burden on the bed fund and medical staff . The results obtained give grounds to recommend the inclusion of interferon alpha-2b preparations (Viferon ® rectal suppositories 3,000,000 IU and Viferon ® gel for external and topical use 36,000 IU/g) in standard COVID-19 therapy regimens in adult patients with mild and moderate forms of the disease.
Modern approaches to the diagnostics and treatment of functional diarrhea
Authors: Sheptulin A. A. , Rabotyagova Yu. S.
Published: September 2022

Modern approaches to the diagnostics and treatment of one of the most common forms of functional bowel disorders, functional diarrhea (FD), are discussed in the article. The clinical features of FD are considered. It is emphasized that various organic diseases (inflammatory bowel diseases, microscopic colitis, celiac disease, lactase defi ciency, etc.) can occur under the mask of FD, which makes the diagnosis of FD a "diagnosis of exclusion" and involves a thorough laboratory and instrumental examination of patients. The main drugs used for the treatment of PD are characterized.
Devlopment of family practice in the Central Military Clinical Hospital named after P. V. Mandryk
Authors: Mashkov T. N. , Krynyukov P. E. , Abashin V. G.
Published: September 2022

The article presents the history of the establishment of health maintenance system for military key personnel and their family members (medical examination, emergency and planned care) with the signifi cant role of general practitioners in the Central Military Clinical Hospital named after P. V. Mandryk.
Academician V. N. Shamov – surgeon, innovator, patriot (for the 140th anniversary of his birth)
Authors: Knopov M. Sh.
Published: September 2022

The article presents the facts about life and career of an outstanding Russian transfusiologist and neurosurgeon, an excellent clinician, a talented health offi cial, a well-known public character, the creator of an original scientifi c school of surgery, an academician of the USSR Academy of Medical Sciences, an honored science worker of the RSFSR, a Lenin Prize laureate, lieutenant general of the medical service, Professor Vladimir Nikolaevich Shamov.
Caractérisation des exploitations agriculture-élevage et origine de l’innovation dans les principaux bassins laitiers de l’Algérie.
Authors: Himeur Zakia , Ikhlef Hacène , Madani Toufik
Published: September 2022

The study focuses on dairy cattle farming systems and the sources of innovation for breeders in the Setif and Souk-Ahras dairy basins recognized by cereals, dairy cattle breeding and irrigated crops. A sample of 140 family farms was selected and surveyed between 2017 and 2018. A typology of livestock systems was constructed using of a PCA and AHC. The results show three groups. G1 retains 68% of breeders with small farms, combining polyculture with dairy cattle breeding; G2, 30% of breeders, the farm is medium-sized and the productive orientation is mixed farming and dairy cattle breeding; G3, made up of large grain farmers and mixed cattle breeders (milk/meat). The cattle breeds exploited are Red Holstein and Montbeliard, 74% dominant. The origin of innovation relating to breeding practices comes mainly from local socio_x0002_technical networks, whereas formal extension by public services is ineffective (0.64 %). It appears that group1 occupies the first position in terms of acquiring information on innovations, followed by G2 and 3. Socio-technical networks operate from 27 to 33% in the 3 groups. The veterinarian contributes 25% in G1 and 2; at 41% in G3.
Rain-fed agriculture risks and management strategies adopted by farmers in two agro_x0002_ecological zones in Al-Hasakeh province of Syria.
Authors: khames AlFraj Naji
Published: September 2022

Based on survey data of 319 rain-fed farmers in Al-Hasakeh, Syria, this study analyses rain-fed farmers’ risk attitudes and farmers’ perceptions of risk and risk management. Furthermore, it analyzes, using multiple regression analysis, the relationship between socio-economic characteristics and farmers’ risk attitudes. The results demonstrate that precipitation shortage was the most important risk source that threaten farmers in both zones. Moreover, risks of diseases and pests and natural disasters were highly perceived by farmers in zone 1. Farmers in zone 2 were more concerned about fire damages and lack of government support. The financial strategy related to the producing at lowest possible cost is perceived as an important strategy to manage risk by farmers in both zones. Spraying for diseases and pests and liquidity are perceived as the most effective risk management strategies by farmers in zone 1, whereas farmers in zone 2 considered liquidity and choose good quality materials as an important strategy. The results also show that some farm and farmers’ characteristics (e.g. age, experience, education, household size, farm size, family labour, extension contact, off-farm work and Co-op Member) significantly impact the risk attitudes of the farmers in both zones.
The impact of Estonia’s established relations with the EU on the success of its post-communist transition
Authors: Walker Charlotte
Published: September 2022

ESAANZ ESSAY PRIZE WINNERThis paper investigates Estonia’s post-communist transition and the successes and challenges of its accession and integration into EU. Specifically, it examines the tumultuous history between Estonia and Russia over the course of the last century and how this affected Estonian independence in the 1990s and the path to EU accession. Due to historical and ethnic factors, Estonians had always been opposed to Russification. This factor, coupled with Estonia’s consolidated liberal democracy and working market economy, has led the country’s accession to the EU to be one of the most successful examples of an effective post-communist transition. EU accession has benefitted Estonia in terms of protection against the ever-lingering threat of Russia, but such benefits have not come without a cost. Estonia has struggled with treatment of minorities and refugees, while its support for EU integration has been tested by the rise of populism both within and beyond its borders.
How much do Central Asian countries participate in Regional Value Chains?
Authors: Sharafeyeva Alfinura
Published: September 2022

This paper estimates the level of Central Asian countries’ participation in regional value chains (RVCs) and global value chains (GVCs) using data from the Eora multi-region input-output table.  The contribution of foreign value-added to gross exports is low both absolutely and compared to baseline estimates for Southeast Asia.  Moreover, despite their geographic, cultural, and historic closeness, Central Asian countries tend to be more integrated into GVCs, whereas RVCs are at a rudimentary stage.  The high trade costs and uncertain trading environment at border-crossing points are among the reasons for underdeveloped RVCs in Central Asia.
The first scientific forum «Genetic resources of Russia» - on legal regulation in the field of bioresources and biological collections
Authors: Khlestkina E. K. , Zakharova M. V. , Nizhnikov A. A. , Geltman D. V. , Chernetsov N. S. , Mikhailova N. A. , Glotov A. S. , Khlestkin V. К. , Zavarzin A. A. , Mokhov A. A. , Tikhonovich I. A.
Published: September 2022

The first scientific forum «Genetic Resources of Russia» took place in Saint Petersburg on 21-24 June 2022. The Forum brought together more than 500 specialists from more than 100 research institutions and universities of the Russian Federation. A round table «Regulations and standards of work with bio-resource collections» was organized within the framework of the Forum in connection with the relevance to create the legislation base for the work with biological collections and regulation of the activities of bioresource centres in the Russian Federation. This publication presents the outcomes of the Forum and its resolution relating to the legal regulation of biological collections.
Formation of the structure and phase composition of wear-resistant steel alloyed with titanium
Authors: Bagrov Valeriy , Hlushkova Diana
Published: September 2022

Problem. In order to increase the durability of the elements of parts and machines operating in conditions of shock-abrasive and abrasive wear during surfacing, alloys doped with such elements as Cr, W, V, Nb and others have been widely used. Currently, these elements are scarce and expensive in Ukraine. The purpose of the work is to improve the quality and wear resistance of the deposited metal by improving the composition of alloying powders by optimizing the content of titanium and carbon. Methodology. Surfacing was done with a TS-17M tractor and an A-1416 automatic head on plates measuring 200x150x25 mm from 20 steel, 500x300x40 mm from 45 steel, and 400x50x40 from 5KHNM steel. AN-22 flux was adopted as a protective flux for layer-by-layer surfacing of alloyed powder based on CaF2 with Cr-Mn-Ti and Cr-Mn-Mo-Ti alloying systems. Results. It was established that the presence of titanium in the amount of 1.6-2.0% with a carbon content of 0.4-0.5% allows obtaining a carbon-free matrix with a carbide strengthening phase. The hardness of the deposited metal in comparison with the martensitic-troostite structure is slightly reduced by 4...6 HRC. The presence of titanium in the amount of 1.6-2.0% with a carbon content of 0.4-0.5% allows obtaining a carbon-free matrix from the carbide strengthening phase. Originality. A rational method of increasing wear resistance of the deposited metal by multicomponent sparing alloying has been developed, with the help of which it is possible to obtain steels with a strengthening carbide phase and high physical and mechanical characteristics. Practical value. A composition of surfacing steels has been developed for work under conditions of shock-abrasive wear for electric arc surfacing, which contains a Cr-Mn-Ti alloy system based on iron (with a small content of Mo and V) and ensures high quality of the weld metal.
Through-Life Information Management for high-tech machinery products: principles and ap-proaches of implementation in Ukraine
Authors: Skvorchevsky Alexander
Published: September 2022

Problem. During the post-war restoration of the Ukrainian industry, it is advisable to use the most modern technologies, including information technology. Significant destruction of industrial facilities is a tragedy, but opens up opportunities to jump to the level of Industry 4.0 and even Industry 5.0, skipping the level of Industry 3.0+, which most Ukrainian enterprises have not yet reached. That is why it is necessary now to study the scientific principles and foundations on the basis of which the future Ukrainian industry and the economy as a whole will be formed. The successful implementation of many other components of the fourth industrial revolution, including Digital Twins and the Internet of Things, depends to a large extent on successful information management. Goal. The paper's aim is to research the prospects and formation of methodological principles for the use of Through-Life Information Management (TLIM) in Ukrainian high-tech engineering. Methodology. The research was based on the current state of information management (including Through-Life Information Management) development in Ukraine analysis and the world level of Through-Life Information Management development. The state of the art in the field of research in Ukraine was compared with the world level of Through-Life Information Management development. Based on this comparative analysis, a synthesis of the implementation of Through-Life Information Management in Ukrainian high-tech engineering principles was performed. Results. It is shown that it is important to implement Through-Life Information Management together with other Continuous Acquisition and Life Cycle Support systems and technologies. The process of introducing Through-Life Information Management into the high-tech engineering industry of Ukraine should be iterative in nature with a constant expansion of the scope of Through-Life Information Management. In addition, Through-Life Information Management, like other ideas and principles of the Continuous Acquisition and Life Cycle Support concept, is important to introduce into the educational process of technical universities and colleges. Originality. For the first time, an algorithmic scheme of the process of Through-Life Information Management implementation in the Ukrainian high-tech machine-building industry is proposed. Practical value. The developed principles of Through-Life Information Management implementation should contribute to the post-war restoration of the Ukrainian machine-building industry with the usage of Industry 4.0 technologies.
OBTAINING MACROMECHANICAL VALUES USING QUANTUM-MECHANICAL DIFFERENTIAL EQUATIONS
Authors:   Kurgan State University, POPOV I.P.
Published: September 2022

The wave function Ψ satisfies the Schrödinger equation for a free particle. Formally, the Schrödinger equation generates the magnitude of mechanical motion of the zero order 0 p = mv 0 (in the sense that it is contained in the Schrödinger equation. Comparison of the wave function Ψ and its gradient implies a formal analogue of the Schrödinger equation, which generates the magnitude of mechanical motion of the first order 1 p = mv 1. From the comparison of the wave function and its time derivative yields a formal analogue of the Schrödinger equation, which generates the magnitude of mechanical motion of the second order 2 p = mv 2/2!. The values of mechanical motion of the zero, first, and second orders are known.Obviously, other formal analogs of the Schrödinger equation can generate mechanical motion of other orders.The aim of the work is to establish such quantities and related regularities that may be of interest, which makes the study relevant. hovering. Then the spatial derivatives will be one-dimensional. The magnitude of the mechanical movement of the third order is 3 p = mv 3/3!. This value is Umov's integral vector for kinetic energy. The magnitude of the mechanical movement minus the first order -1 p = mv -1 is a reverse impulse. The meaning of this quantity and its relevance is established by the theorem: in a hy- drogen-like atom, the quantity m v-1 is quantized. A fixed (unchanged) quantum is a quantity m v-1 correspond- e e 0 ing to the basic energy level. Almost all of the results obtained were a consequence of the use of quantum mechanical differential equations, however, the results themselves are predominantly macromechanical. The quantities of mechanical motion of various orders are generated by formal analogs of the Schrödinger equation. In all formal analogs of the Schrödinger equation, the orders of the partial derivatives differ by one. For quantities of motion with a positive degree of velocity, the order of the temporal derivatives is higher than that of the spatial ones. For quantities with a negative degree, the order of spatial derivatives is higher.
EMBRYONIC DATA IN BIOTECHNOLOGICAL STUDIES OF WHEAT DROUGHT RESISTANCE FOR BREEDING PURPOSES
Authors:   Ufa Institute of biology, KRUGLOVA N.N. , SELDIMIROVA O.A., ,   Ufa Institute of biology, ZINATULLINA A.E. ,   Ufa Institute of biology
Published: September 2022

Drought as an unfavorable combination of meteorological conditions under which plants experience a prolonged water shortage in the air and soil is one of the most common abiotic stress factors, the effect of which leads to significant crop losses of economically important plants, including cereals. One of the promising directions of biotechnological assessment of the resistance of existing and newly created genotypes of cereals to this abiotic stress factor for breeding purposes is the use of embryo culture in vitro, when embryos of the particular stage of development are used as explants. Especially promising is the in vitro cultivation of immature embryos that are at the critical stage of autonomy. Such embryo does not depend on the physiological factors of the maternal individual and is able to independently give rise to a full-fledged regenerant under adequate in vitro conditions. At the same time, to identify the stage of autonomy, complex cytophysiological studies of the embryo in the dynamics of development from the zygote to the mature structure are necessary. Embryonic analysis is also necessary during evaluation of the obtained regenerants in the laboratory ex vitro and especially in the field in vivo conditions. The review article, using the example of spring soft wheat, presents some results of comprehensive investigation by the researchers of the plant physiology laboratory UIB UFRC RAS on the use of cytophysiological data to identify the critical stage of embryo autonomy, as well as on the application of the obtained results in the elaboration of biotechnology of embryo culture in vitro. Together with the researchers of the laboratory of breeding and seed production of spring wheat of the RIAS UFRC RAS, the prospects of using culture in vitro of immature autonomous embryos in the creation of drought-resistant hybrid wheat lines are shown. Experimental studies were conducted on the basis of theoretical formulation by RAS corresponding member T.B. Batygina, whose memory this article is dedicated to.
BIOLOGY OF RARE SPECIES GLOBULARIA PUNCTATA (GLOBULARIACEAE) IN BASHKIRIA NATIONAL PARK
Authors:   South Ural Botanical Garden-Institute, ABRAMOVA L.M. , MUSTAFINA A.N. ,   South Ural Botanical Garden-Institute, MULDASHEV A.A., ,   Ufa Institute of biology, SULTANGAREEVA L.A. ,   National Park «Bashkiria»
Published: September 2022

A study of the rare species Globularia punctata Lapeyr. was carried out. (Globulariaceae) in the National Park "Bashkiria" (Bashkortostan of Republic). The species is included in the Red Books of Russian Federation and Bashkortostan of Republic . G. punctata is a European species; in the South Urals, it has the easternmost fragment of its range. The features of biology and ontogenetic structure of the species have been studied. An assessment of the current state of two cоenopopulations located on the territory of the National Park is given. It was revealed that the CP Balatau is numerous (2-3 thousand individuals) and denser (10,3 ind./m2); the CP Tallytau is small (150-300 individuals), with a lower density (4.7 ind./m2). The study of the morphometric parameters of plants showed that qualitative traits are leading in the CP Tallytau, and quantitative traits are leading in the CP Balatau. All characters have a normal degree of variability (8.7-42.6%). According to the "delta-omega" classification, both CPs are young (CP Balatau - ∆ = 0.17, ω = 0.44; CP Tallytau - ∆ = 0.28, ω = 0.58). The recovery index in both CPUs is above one, the aging index is low. The ontogenetic spectrum of both CPs is left-sided, with a maximum on virginal individuals. The condition of the studied populations of G. punctata is stable and satisfactory. Anthropogenic impacts and overgrowth of its habitats with shrubs can be a threat to the species.
INTRODUCTION OF TWO SAMPLES OF KUNTA ONIONS IN THE SOUTH URAL BOTANICAL GARDEN-INSTITUTE
Authors:   South Ural Botanical Garden-Institute, TUKHVATULLINA L.A. , ABRAMOVA L.M. ,   South Ural Botanical Garden-Institute
Published: September 2022

The paper presents the results of introductoin study of two samples of A. kunthianum Vved.: information is given on the study of the seasonal rhythm of development, seed productivity and the peculiarity of reproduction. A. kunthianum is endemic to the Caucasus, grows in highland meadows and rocks. The studied samples of A. kunthianum were grown from seeds, the plants entered a generative state in the 2nd year of life. The flowering phase of the German specimen occurs at the end of the 2nd decade of June and lasts 23 days. The Binsky specimen blooms at the end of the 3rd decade of June, lasting up to 20 days. According to the flowering dates, A. kunthianum belongs to the early-middle-summer. The duration of the interphase is the beginning of vegetation - the beginning of flowering in the studied samples of this onion is on average 65-73 days (German and Binsky, respectively). A. kunthianum according to the phenorhethmotype belongs to the short-vegetating summergreen, vegetation ends in the fruiting phase (in the 2nd-3rd decade of July). Seed ripening occurs in late July - early August. The number of flowers in the umbrella of the German sample is from 81 to 105 pcs., In Binsky - from 48 to 101 pcs. On average, less by 18 pcs.; the number of fruits in inflorescences of the German specimen has from 43 to 62 pcs., Binsky - from 30 to 54 pcs. On average, less by 11.7 pcs.; real seed productivity of the umbrella in the German sample - from 77 to 142 pcs. Seeds, in the bin sample - from 65 to 90 pcs.; potential seed productivity of one inflorescence in a Germanic sample from 468 to 630 pieces of seeds, in a binary sample - from 286 to 605 pieces of seeds. The average productivity ratio of the studied samples is only 17 and 18.6% (German and binary, respectively). In terms of the sum of points, few promising plants are assigned to the group (13 points).
EFFECT OF MEAN PRESSURE ON THE BENDING OF A LONG CYLINDRICAL SHELL
Authors:   Institute of Mechanics and Mechanical Engineering FITC KazNC RAS 2 Bashkir State University 3 R.R. Mavlyutov Institute of Mechanics, ILGAMOV M.A.
Published: September 2022

A review is given of studies of the interaction of pressures on both sides of a thin elastic plate and a cylindrical shell and changes in the curvature of their middle surface during bending. The influence of the average pressure has been established so far by refining the distributed transverse force in the known equations for the bending of a long cylindrical shell. In this paper, this influence is taken into account when deriving the equation for bending with wave formation along the circumference and the absence of waves along its length.
COMPARATIVE ANALYSIS OF BIOCHEMICAL PARAMETERS OF SPERMOPLASM OF STALLIONS WITH NORMAL AND LOW PROGRESSIVE SPERM MOTILITY AFTER CRYOPRESERVATION
Authors:   All-Russian Research Institute for Horse Breeding, ATROSCHENKO M.M. , SHITIKOVA A.M. ,   Ryazan State Medical University, ZVYAGINA V.I. ,   Ryazan State Medical University, ENGALYCHEVA M.G. ,   Ryazan State Medical University, MARSYANOVA YU.A. ,   Ryazan State Medical University, NOVIKOVA YU.E. ,   Ryazan State Medical University, ZHIRKOVA M.A. ,   Ryazan State Medical University
Published: September 2022

The aim of this work was to perform a comparative analysis of the biochemical parameters of spermoplasm of stallions with normal and low sperm progressive motility after cryopreservation. Seminal plasma of 34 Arabian stallions was collected during the breeding season (February-May). The activity of H+-ATPase was determined on the SF-2000 spectrophotometer (OKB Spectrum LLC, Russia), the activity of alkaline phosphatase (ALP), creatine kinase (СK), alanine aminotransferase (ALT), aspartate aminotransferase (AST), α-amylase (AA), lactate dehydrogenase (LDH), as well as the concentration of triacylglycerin (TAG), glucose and fructose - on a biochemical analyzer AU 680 (Beckman Coulter, USA), cytochrome oxidase activity, lactate and citrate concentration - on a semiautomatic analyzer Stat Fax 1904+ (Awareness Technology Inc, USA). The succinate content was determined on an IF analyzer StatFax 3200 (Awareness Technology Inc, USA). Statistical analysis was carried out using the Statistica 10 program and the nonparametric Mann-Whitney U-test. It was found that in the spermoplasm of stallions with low progressive sperm motility after freezing-thawing, the activity of ALT (p=0.012), AST (p=0.012), LDH (p=0.017) and H+-ATPase (p=0.037) is statistically significantly higher than in the spermoplasm of stallions with normal progressive sperm motility after cryopreservation. The results obtained may be associated with damage to the cytoplasmic and mitochondrial membranes of spermatozoa, which leads to a drop in ATP synthesis. The latter may be accompanied by a decrease in progressive motility in spermatozoa after cryopreservation. The research was supported by the grant of the Russian Science Foundation No. 20-16-00101.
Human Parvovirus B19 Nonstructural Protein 1 Regulates GATA1 Expression via the Notch Signaling Pathway in K562 Cell Line
Authors: Zeng Dongxin , Zheng Junwen , Feng Shuwen , Fan Panpan , Zhao Dongchi
Published: September 2022

Background: Human parvovirus B19 (B19) infection can affect the hematopoietic arrest in fetus by hindering the differentiation and maturation of erythroid progenitor cells. B19 nonstructural protein 1 (NS1) has been shown to inhibit the differentiation of erythroid progenitor cells. The goal of this study is to explore the role of B19 NS1 in the regulation of GATA1 and Notch signaling pathway in hematopoietic cells. Methods: The B19 NS1 expression plasmid was reconstituted, and the possibility of NS1 regulating GATA1 and GATA2 expression modulated by Notch-Hes pathway was tested by qRT-PCR and western blot. Immunofluorescence assays were conducted to visualize pNS1 in K562 cells. Results: We demonstrate that B19 NS1 inhibited GATA1 and induced Hes1/Hes5, which is involved in the activation of Notch signaling pathway. Meanwhile, NS1 exhibited promoting effects on GATA2 expression. Activation of the Notch signaling pathway up-regulated its downstream transcriptional repressor family Hes, thereby inhibiting the expression of GATA gene in K562 cells. Conclusions: The results show that B19 NS1 protein negatively regulates GATA1 related nuclear transcription and may interfere with hematopoietic cell differentiation.
The Synergism of Natural Compounds and Conventional Therapeutics against Colorectal Cancer Progression and Metastasis
Authors: Liang Zimao , Xie Han , Shen Weixing , Shao Le , Zeng Li , Huang Xingxing , Zhu Qianru , Zhai Xiangyang , Li Keshuai , Qiu Zejing , Sui Xinbing , Cheng Haibo , Wu Qibiao
Published: September 2022

Cancer progression and metastases are the leading causes of poor outcomes in patients with colon cancer. Colon cancer metastasis is a multigene, multistep, multistage complex process in which target genes, microRNAs, epithelial-stromal transformation, tumour stem cells, the tumour microenvironment, and various cell signalling pathways are implicated in the progression and metastasis of colon cancer. Although conventional therapies have made significant advances in treating the progression and metastasis of colorectal cancer, they have failed to improve survival outcomes. Natural compounds may have more significant potential in preventing and treating colon cancer. Active natural compounds exert their antitumor effects by inducing tumour cell differentiation, promoting tumour cell apoptosis, inhibiting tumour vascular growth, and regulating immunity. Natural compounds, combined with conventional therapies, can target mutant genes and various cellular signalling pathways, inhibit epithelial-stromal transformation, and improve the tumour microenvironment to inhibit tumour progression and metastasis. The synergism of natural compounds and conventional therapeutics has the potential to become a promising therapy for treating colorectal cancer progression and metastases.
Using Molecular Targets to Predict and Treat Aortic Aneurysms
Authors: Zhou Xiaonan , Liu Gang , Lai Hao , Wang Chunsheng , Li Jun , Zhu Kai
Published: September 2022

Aortic aneurysms are life-threatening vascular diseases associated with high morbidity, and usually require prophylactic surgical intervention. Current preventative management of aortic aneurysms relies on the diameter and other anatomic parameters of the aorta, but these have been demonstrated to be insufficient predictive factors of disease progression and potential complications. Studies on pathophysiology of aortic aneurysms could fill this need, which already indicated the significance of specific molecules in aortic aneurysms. These molecules provide more accurate prediction, and they also serve as therapeutic targets, some of which are in preclinical stage. In this review, we summarized the inadequacies and achievements of current clinical prediction standards, discussed the molecular targets in prediction and treatment, and especially emphasized the molecules that have shown potentials in early diagnosis, accurate risk assessment and target treatment of aortic aneurysm at early stage.
Environment-by-PGS Interaction in the Classical Twin Design: An Application to Childhood Anxiety and Negative Affect.
Authors: Bruins Susanne , Hottenga Jouke-Jan , Neale Michael C. , Pool René , Boomsma Dorret , Dolan Conor V.
Published: September 2022

One type of genotype-environment interaction occurs when genetic effects on a phenotype are moderated by an environment; or when environmental effects on a phenotype are moderated by genes. Here we outline these types of genotype-environment interaction models, and propose a test of genotype-environment interaction based on the classical twin design, which includes observed genetic variables (polygenic scores: PGSs) that account for part of the genetic variance of the phenotype. We introduce environment-by-PGS interaction and the results of a simulation study to address statistical power and parameter recovery. Next, we apply the model to empirical data on anxiety and negative affect in children. The power to detect environment-by-PGS interaction depends on the heritability of the phenotype, and the strength of the PGS. The simulation results indicate that under realistic conditions of sample size, heritability and strength of the interaction, the environment-by-PGS model is a viable approach to detect genotype-environment interaction. In 7-year-old children, we defined two PGS based on the largest genetic association studies for 2 traits that are genetically correlated to childhood anxiety and negative affect, namely major depression (MDD) and intelligence (IQ). We find that common environmental influences on negative affect are amplified for children with a lower IQ-PGS.
A Novel Process Production of Calophyllum Inophyllum Biodiesel with Electromagnetic Induction
Authors: Syam Sudirman , Kurniati Sri , Soeparman Sudjito , Yuwono Sudarminto Setyo , Hakim Lukman
Published: September 2022

A novel method as proposed in the production of Calophyllum inophyllum biodiesel has been investigated experimentally. This study reports the results of biodiesel processing with electromagnetic induction technology. The applied method is aimed to compare the results of Calophyllum inophyllum biodiesel processing among conventional, microwave and electromagnetic induction. The degumming, transesterification, and esterification process of the 3 methods are measured by stopwatch to obtain time comparison data. Characteristics of viscosity, density, and Fatty Acid Metil Ester (FAME) are obtained from testing of a Gas Chromatography-mass Spectrometry (GCMS) at the Integrated Research and Testing Laboratory, Gadjah Mada University, Yogyakarta. The results present that the biodiesel produced by this method satisfies the biodiesel standards and their characteristics are better than the biodiesel produced by conventional and microwave methods. The electromagnetic induction method also offers a fast and easy route to produce biodiesel with the advantage of increasing the reaction rate and improving the separation process compared to other methods. This advanced technology has the potential to significantly increase biodiesel production with considerable potential to reduce production time and costs.
Why economists should learn more from nature?
Authors: Quý Khúc Văn
Published: September 2022

As nature degrades and the environment becomes more polluted, economists frequently use tax tools to mitigate and control the negative externality of the problem. The Pigou tax is, of course, one of the most common environmental economic instruments. However, it seems that this is not the best solution to the problem because environmental pollution and climate change are becoming more and more serious. While I appreciate what economists who have done in devising policies over the last several decades, I believe their efforts are insufficient to solve the problem.
Public Gender Policy for Contextualization of Emergence
Authors: Penaha Maria , Pehna Zaroora
Published: September 2022

Public Gender Policy for Contextualization of Emergence
EKONOMI MONETER
Authors: Akbar Muh.
Published: September 2022

A. Pengertian Ekonomi MoneterEkonomi moneter merupakan suatu cabang ilmu ekonomi yang membahas tentang peranan uang dalam mempengaruhi tingkat harga-harga dan tingkat kegiatan ekonomi dalam usaha.B. TujuanEkonomiMoneterKonvensional Transaksi Berjaga-jaga spekulasiC. Ruang Lingkup Ekonomi Moneter Fungsi dan peran uang dalam perekonomian Sistem dan pengaruh moneter terhadap jumlah uang yang beredar Struktur dan fungsi bank sentral Pengaruh jumlah uang yang beredar dan kredit terhadap kegiatan ekonomi Pembayaran serta sistem moneter internasionalD. TujuanEkonomiMoneter Kesempatan kerja : semakin besar peningkatan produksi juga membantu masyarakat yang menjadi pengangguran. Kestabilan harga : harga makin kian tinggi membuat masyarakat menjadi resah, untuk mencegah kenaikan harga, pemerintah menstabilkan harga agar bisa tidak mengalami kenaikan harga setiap tahunnya. Neraca pembayaran internasional : neraca pembayaran internasional yang seimbang menunjukkan stabilitas ekonomi di suatu negara.
Mindspongebusiness
Authors: Khuc Van Quy
Published: September 2022

To nurture and build our next generation of businessman associated with an ecosurplus culture, high value culture, I advocate Mindspongebusiness...
A roadmap to reduce information inequities in disability with digital health and natural language processing
Authors: Newman-Griffis Denis , Hurwitz Max B. , McKernan Gina P. , Houtrow Amy J. , Dicianno Brad E.
Published: September 2022

People with disabilities disproportionately experience negative health outcomes. Purposeful analysis of information on all aspects of the experience of disability across individuals and populations can guide interventions to reduce health inequities in care and outcomes. Such an analysis requires more holistic information on individual function, precursors and predictors, and environmental and personal factors than is systematically collected in current practice. We identify three key information barriers to more equitable information: (1) a lack of information on contextual factors that affect a person’s experience of function; (2) under-emphasis of the patient’s voice, perspective, and goals in the electronic health record; and (3) a lack of standardized locations in the electronic health record to record observations of function and context. Through analysis of rehabilitation data, we have identified ways to mitigate these barriers through the development of digital health technologies to better capture and analyze information about the experience of function. We propose three directions for future research on using digital health technologies, particularly natural language processing (NLP), to facilitate capturing a more holistic picture of a patient’s unique experience: (1) analyzing existing information on function in free text documentation, (2) developing new NLP-driven methods to collect information on contextual factors, and (3) collecting and analyzing patient-reported descriptions of personal perceptions and goals. Multidisciplinary collaboration between rehabilitation experts and data scientists to advance these research directions will yield practical technologies to help reduce inequities and improve care for all populations.