bluuebunny/crossref_metadata_2025 huggingface dataset:
Missionary theology and the peopling of pre-Columbian America: John Oxenbridge’s “A plea for the dumb Indian” (ca. 1666)
Authors: Cogley Richard W.
Published: August 2021

John Oxenbridge was a 17th-century Puritan minister who lived in England, Bermuda, Suriname, Barbados, and New England. During his residence in Suriname, a short-lived English colony, he wrote a missionary treatise he entitled “A plea for the dumb Indian.” The work was never published and survives partially in non-digitalized manuscript form at the Massachusetts Historical Society in Boston. One of the intact portions of the manuscript is a discussion of the settlement of pre-Columbian America. Oxenbridge held that the Native Americans were descended from ancient Scythians, the semi-nomadic and “uncivilized” peoples of the vast Eurasian Steppe, who had entered America through “Anian,” an early modern designation for the region around the Bering Strait. He also thought that two other peoples later settled in pre-Columbian America: Welsh adventurers sailed across the Atlantic but soon intermarried with the Native Americans and disappeared as a distinct people, and some of the lost tribes of Israel entered the New World through Anian. These lost Israelites still survived and continued to observe the Mosaic Law. They never intermarried with the Native Americans; however, they passed on a “tincture of Israels customs” to their Indian neighbors. Oxenbridge’s discussion of the peopling of pre-Columbian America may seem like an antiquarian curiosity of little interest to historians of Christian missions. But for him it remained relevant to the present day. The Welsh migration, which he thought predated Spanish and French colonization, legitimated the English imperial claim in America. More importantly, the presence of lost Israelites in Scythian America would facilitate the conversion of the Native Americans.
A Limited Thoracocervical Approach for Accessing the Anterior Mediastinum in Retrosternal Goiters: Surgical Technique and Implications for the Management of Head and Neck Emergencies
Authors: Vlastarakos Petros V. , Trinidade Aaron , Jaberoo Marie-Claire , Mochloulis George
Published: August 2021

In this article we describe the surgical management of retrosternal goiters via a limited thoracocervical approach, and we explore how the respective surgical know-how can be used in the management of the carotid blowout syndrome. Four cases involving patients who had undergone thyroidectomy via a limited thoracocervical approach are retrospectively reviewed. An acute blowout of the innominate artery managed with the same principal surgical technique is also reviewed. Tree patients had a total thyroidectomy and one had a hemithyroidectomy. No malignancy was found. There was no mortality or unexpected morbidity from the limited thoracocervical approach. The median length of the inpatient stay was 3 days. The blowout survivor lived for 9 months, with no rebleeding and with an acceptable quality of life. We conclude that a limited thoracocervical approach can be safely performed by head and neck surgeons for accessing the anterior mediastinum in retrosternal goiters, and the respective surgical know-how can be used in the immediate management of an acute carotid blowout syndrome with satisfying long-term results and provision of quality end-of-life care.
Refugee depictions in Dutch Internet news
Authors: Konings Roy , Notten Natascha
Published: August 2021

Much has been written about the depiction of refugees in newspapers and television news, yet far less is known about how refugees are portrayed in Internet news. In this era of increasing Internet use, it is important to also study how refugees are depicted by Internet news websites. We used a quantitative coding sheet to investigate how Dutch news websites covered refugees. Our research found, first, that Dutch Internet news reports rather positively about refugees. This finding is directly linked to a conceptual decision, however, as we categorized references to victimization as positive coverage of refugees. Second, we found no significant difference between commercial and public Internet news sources in their depiction of refugees. Finally, we found a tendency towards depersonalization of refugees across all of the Dutch Internet news sources examined, which is reflected in the more frequent use of thematic over episodic frames.
MRI-visible perivascular spaces in basal ganglia but not centrum semiovale or hippocampus were related to deep medullary veins changes
Authors: Zhang Kemeng , Zhou Ying , Zhang Wenhua , Li Qingqing , Sun Jianzhong , Lou Min
Published: August 2021

Our purpose is to assess the role of deep medullary veins (DMVs) in pathogenesis of MRI-visible perivascular spaces (PVS) in patients with cerebral small vessel disease (cSVD). Consecutive patients recruited in the CIRCLE study (ClinicalTrials.gov ID: NCT03542734) were included. Susceptibility Weighted Imaging-Phase images were used to evaluate DMVs based on a brain region-based visual score. T2 weighted images were used to evaluate PVS based on the five-point score, and PVS in basal ganglia (BG-PVS), centrum semiovale (CSO-PVS) and hippocampus (H-PVS) were evaluated separately. 270 patients were included. The severity of BG-PVS, CSO-PVS and H-PVS was positively related to the increment of age (all p < 0.05). The severity of BG-PVS and H-PVS was positively related to DMVs score (both p < 0.05). Patients with more severe BG-PVS had higher Fazekas scores in both periventricle and deep white matter (both p < 0.001) and higher frequency of hypertension ( p = 0.008). Patients with more severe H-PVS had higher frequency of diabetes ( p < 0.001). Besides, high DMVs score was an independent risk factor for more severe BG-PVS ( β = 0.204, p = 0.001). Our results suggested that DMVs disruption might be involved in the pathogenesis of BG-PVS.
John Davies Thomas: Chloroformist in London and pioneer South Australian doctor
Authors: Haridas Rajesh P
Published: August 2021

John Davies Thomas (1844–1893) described a two-ounce drop-bottle for chloroform in 1872 while he was a resident medical officer at University College Hospital, London. After working as a ship’s surgeon, he settled in Australia. In May 1875, Thomas presented a paper on the mortality from ether and chloroform at a meeting of the Medical Society of Victoria in Melbourne, Victoria. Surveys conducted in Europe and North America had established that the mortality from chloroform was eight to ten times higher than that from ether. At that time, chloroform was the most widely administered anaesthetic in Australia. Thomas’ paper was published in The Australian Medical Journal and reprinted by the Medical Society of Victoria for distribution to hospitals in the Colony of Victoria. Later that year, Thomas moved to Adelaide, South Australia, where he may have been influential at the Adelaide Hospital in ensuring that ether was administered more often than chloroform. It does not appear that Thomas’ papers on anaesthesia had a significant effect on the conduct of anaesthesia in Victoria or New South Wales.
Controversy on the Association of the Critical Shoulder Angle and the Development of Degenerative Rotator Cuff Tears: Is There a True Association? A Meta-analytical Approach
Authors: Rojas Lievano Jorge , Bautista Maria , Woodcock Santiago , Fierro Guido , González Juan Carlos
Published: August 2021

Background:

The role of the critical shoulder angle (CSA) as a risk factor for rotator cuff tear (RCT) remains controversial. Studies on the association between the CSA and RCT show considerable differences in design, and this could be responsible for the variation in study results.

Purpose:

To (1) describe the reliability of CSA measurement and (2) evaluate the results of the studies reporting the association between the CSA and RCT using meta-analytical techniques to explore potential sources of variation of study results.

Study Design:

Systematic review and meta-analysis; Level of evidence, 4.

Methods:

MEDLINE, EMBASE, and CINAHL electronic databases were searched through June 30, 2019. Case-control and cross-sectional studies reporting the association of the CSA and RCT were selected. The weighted mean difference in the CSA was estimated using a random-effects model. Prediction interval was computed to better express uncertainties in the effect estimate. Metaregression and subgroup analyses were performed to explore potential sources of heterogeneity.

Results:

A total of 14 studies, including 1154 cases and 1271 controls, were identified. Of these studies, 79% (11/14) assessed the reliability of the CSA measurement, demonstrating an excellent intraobserver (range, 0.91-0.99) and interobserver (range, 0.87-0.99) reliability. Compared with controls, cases with RCT showed larger measurements of the CSA (3.3° [95% CI, 2.3°- 4.4°]). However, there was a high heterogeneity ( I2 = 93%), and the 95% prediction interval (-0.4° to 7.1°) included no difference in the CSA. Results of the metaregression analysis showed a significant association of several methodological aspects with the heterogeneity. The difference in the CSA tended to be larger when only full-thickness tears were included, when no specific defined criterion for assessing radiographic viewing perspective was used, in studies with smaller sample sizes, and in studies at higher risk of bias.

Conclusion:

While the CSA can be reliably measured, the difference in the CSA between cases and controls varied from very large to modest or almost no difference. Several determinants of heterogeneity were determined. Owing to this heterogeneity, it is difficult to gain an insight into the strength and exact nature of the association between the CSA and RCT with the current evidence.
Job Resignation in Nursing Homes During the COVID-19 Pandemic: The Role of Quality of Employer Communication
Authors: Cimarolli Verena R. , Bryant Natasha S. , Falzarano Francesca , Stone Robyn
Published: August 2021

Limited research has examined coronavirus disease 2019 (COVID-19)-related work stressors experienced by nursing home (NH) employees and how these stressors may impact employees’ decision to resign when taking organizational factors into account. Thus, the purpose of this study was to investigate whether quality of employer communication related to COVID-19 and staff preparedness to care for residents with COVID-19 can mediate the effects of COVID-19-related stressors on NH employees’ ( N = 1,730) decision to resign. Results from path analyses indicate that higher quality of communication and more optimal preparedness mediated the relationship between COVID-19-related stressors and likelihood of resignation. Specifically, higher levels of COVID-19-related stressors were indirectly associated with reduced likelihood of resigning through the paths of more optimal communication and preparedness. Findings underscore the importance of effective employer communication during emergencies in NHs.
Design and analysis of motion and energy regulating vibration harvester
Authors: Satpute Nitin , Jugulkar Lalitkumar , Jabade Siddharth , Korwar Ganesh , Arawade Swapnil
Published: August 2021

In this paper a novel design of energy harvester has been proposed, which converts harmonic or random vibrations energy into useful electric power. The energy harvester comprises of mechanical motion rectifier, motion regulator, strain energy storage element and a rotary electric generator. The mechanical motion rectifier comprises of a spatial mechanism with unidirectional bearings and spherical joint that converts the linear oscillating force into unidirectional torque pulses. Further, motion regulating mechanism directs the energy flow to the strain energy storage element and drives the electric generator. The arrangement ensures that flow of vibration energy is regulated such that it is stored in the spring up to a threshold limit and thereafter dissipated to the electric generator. Rigid body simulations in Adams and Matlab have been used in design and analysis of the energy harvester with investigations for the effect of significant design parameters. Experimentation on a prototype has been performed to validate the numerical model which delivered 4.13 W of peak power and average power of 0.12–0.52 W within frequency range of 1–15 Hz. Simulation results on a real size device with higher torsion spring stiffness indicates that the harvester can operate with 69.8% efficiency and deliver 0.32–2.45 W of average power for frequency of 0.5–4 Hz.
Robust nonlinear control integrated operator theory and sliding mode technology for a system considering the change of thermal conductivity
Authors: Deng Mingcong , Yamakita Akihiro
Published: August 2021

Based on the mathematical modelling of a cooling and heat system using Peltier elements, thermal conductivity influencing the characteristics of Peltier device is taken into account to increase the temperature control accuracy. Integrating operator theory and sliding mode technology, the control system is designed, where the robust stability of the nonlinear system is ensured with operator-based right coprime factorization and robust stability condition is proposed for system’s robustness analysis. Besides, for the tracking performance of the designed nonlinear system, sliding mode technology is also adopted. New simulations and experiments of the proposed system demonstrate the effectiveness.
Perceptions on the Implementation of Accreditation Requirements and Standards in the Primary Healthcare Centres, Ras Al Khaimah, UAE
Authors: Seraidi Salhah Taresh Ahmed Ali Al , Adam Shukri , Shivappa Pooja
Published: August 2021

The purpose of this study was to assess the changes resulting from the implementation of an accreditation programme on quality of care. This study aims to find the association between nurses’ perceptions of the implementation of accreditation requirements and standards in the healthcare services at primary health centres (PHCs) with selected demographic variables (age, gender, nationality, level of education and designation). A cross-sectional quantitative study was conducted by a self-administered questionnaire. The study sample ( n = 130) nurses who were working in accredited governmental PHCs and the research was conducted in eight PHCs out of the 18 PHCs in Ras Al Khaimah (RAK), UAE. The association between nurses’ perceptions on the implementation of accreditation requirements and standards in the healthcare services in PHCs with selected demographic variables: gender X2 (2. N = 130) = 0.28, p > 0.05, age X2 (1. N = 130) = 1.76, p > 0.05, level of education X2 (6. N = 130) = 0.94, p < .05, designation X2 (4. N = 130) = 13.3, p < .05. Level of education and designation demonstrates the same perception levels (60% moderate and 40% high). There is a significant association between nurses perception of the implementation of JCI accreditation requirement and standard in health serive of PHC’s with the selected demographic data age and designation (p < 0.05). However level of education and gender are not significant(p > 0.05). Nurses are the backbone of any healthcare setting, and they spend more time with the patient. Being a part of the quality of care and patient safety is essential.
Factors Affecting Organisational Learning: The Case of a Medical Centre
Authors: Shamir-Bladerman Orit
Published: August 2021

Despite many studies that examined the relationship between organisational learning and organisational culture, none examined whether the levels of learning differ within a given organisation and if so, what factors lead to this difference. This article is based upon a study on organisational learning and investigates the relationship among organisational learning, culture and structure. Quantitative research was conduct on organisational learning practices in 17 medical departments of a large hospital in Israel. Three main categories of variables were examined: mapping the learning mechanisms, characterising the organisational culture and examining the organisational structure of various departments. Organisational learning was measured by means of a set of organisational learning mechanisms used in each medical department. Because data were collected from individuals, it was necessary to control and overcome self-report and common method bias. Reverse scoring of items, the use of variation in wording of items and guaranteeing anonymity to respondents helped control common method bias. As expected, it was found that those departments do differ one from the others by the extent to which organisational learning mechanisms are systematically used. The article further presents and discusses the effects of some structural and cultural factors upon levels of organisational learning on those departments. Both the method and the results of this research differ from previous studies of organisational learning; thus, the article sheds a new light on the concept of organisational learning. The study points to the importance and need of organisations to adopt a culture that encourages use of these organisational learning mechanisms to create effective and ongoing organisational learning. Increasing awareness among hospital departments of organisational learning as an essential process for coping with environmental change is also an important practical contribution.
An Examination of Per Capita Income Convergence in Emerging Market Economies
Authors: Sharma Prakarti , Sharma Nidhi
Published: August 2021

The study intends to examine the convergence of per capita income in emerging market economies (EMEs) toward a steady state for the post reform period (1999–2019). Cross-sectional regression analysis has been performed for unconditional convergence and a panel data regression to find the conditional convergence in EMEs. Sigma convergence has been applied to find the dispersion of income level in EMEs. In addition, to find the impact of global financial crisis on the convergence process of EMEs, unit root test with one structural break has been applied. The findings indicate that there exists unconditional convergence among EMEs toward a common steady state. Further, the results show a significant role of all control variables except education in the growth process but prove the absence of conditional convergence in selected EMEs. The results of sigma convergence find that the dispersion of per capita income is declining in EMEs, showing the sign of sigma convergence in EMEs. However, this study provides further scope to examine per capita income convergence among EMEs by including other variables and their effect on the convergence process of EMEs.
Emergency department visits for psychiatric care during the first lockdown in Melbourne
Authors: Jagadheesan Karuppiah , Danivas Vijay , Itrat Annie , Lakra Vinay
Published: August 2021

Objective:

We investigated the nature of patients presenting to an emergency department (ED) during the first lockdown in Melbourne.

Method:

This study compared adult patients in the North West Area Mental Health Service catchment area who presented to the local ED during the lockdown (16 March–12 May 2020) and the control (16 March–12 May 2019) periods.

Results:

The control and lockdown periods included 321 and 332 patients, respectively. Compared to the control period, patients with non-English speaking backgrounds and presenting complaints of suicidal behaviour were lower, whereas patients with anxiety symptoms and needing compulsory assessments were higher in the lockdown period. Diagnostically, the lockdown period included more patients with anxiety disorders, substance use disorders and psychotic disorders.

Conclusions:

ED access for acute psychiatric care can vary depending upon certain patient characteristics during lockdowns.
Vericiguat: A Novel Oral Soluble Guanylate Cyclase Stimulator for the Treatment of Heart Failure
Authors: Campbell Nicole , Kalabalik-Hoganson Julie , Frey Kathleen
Published: August 2021

Objective

To review the efficacy and safety of vericiguat indicated to reduce the risk of cardiovascular death and heart failure (HF) hospitalization following hospitalization or need for outpatient intravenous diuretics in adult patients with chronic symptomatic HF and ejection fraction (EF) less than 45%.

Data Sources

A literature search through MEDLINE with search terms MK1242, BAY 1021189, and vericiguat was conducted. Product labeling and English-language studies assessing pharmacokinetics, pharmacodynamics, efficacy, or safety of vericiguat were included.

Study Selection and Data Extraction

Preclinical and clinical studies describing the efficacy and safety of vericiguat were included.

Data Synthesis

The phase 3 VICTORIA clinical trial demonstrated a lower composite primary outcome of death from cardiovascular causes or first hospitalization in the vericiguat group compared to placebo. Total hospitalizations for HF in the vericiguat group were significantly less compared to placebo. The composite secondary outcome of death from any cause or first HF hospitalization was significantly less in the vericiguat group.

Relevance to Patient Care and Clinical Practice

The addition of vericiguat offers a new treatment option for those in whom rehospitalization or recurrent outpatient intravenous diuretic treatment is a concern. Given high rates of nonadherence in HF patients, vericiguat represents an additional treatment option, especially for patients who do not tolerate available HF therapies.

Conclusion

Vericiguat is a novel soluble guanylate cyclase stimulator that is safe and effective for reducing the risk of cardiovascular death and HF hospitalization in adults with symptomatic chronic HF and reduced EF.
Collaborative Care: Integrating Behavioral Health Into the Primary Care Setting
Authors: Reising Virginia , Diegel-Vacek Lauren , Dadabo Lisa , Corbridge Susan
Published: August 2021

Introduction:

Integrated behavioral health is a model of health care that aims to meet the complex health care needs of patients in primary care settings. Collaborative Care (CC) is an evidence-based model incorporating an interdisciplinary team to improve outcomes for behavioral health disorders commonly seen by primary care providers.

Aim:

CC was implemented in a nurse-managed health center in a medically underserved community of Chicago with a team of family nurse practitioners, psychiatric mental health nurse practitioners, and a licensed clinical social worker.

Methods:

Integration of the CC model required restructuring of the patient visit, the care team, and financial operations. Weekly team meetings were held for interdisciplinary case consultation and training for the primary care team by the psychiatric nurse practitioner. The model includes suggested goals of reducing patient scores of validated depression (Patient Health Questionnaire–9) and anxiety (Generalized Anxiety Disorder–7) screening tools to a score less than 5 points or to less than 50% of original score.

Results:

During the initial year of implementation, 166 patients received care under the CC model, with 64 patients currently receiving active care. In this cohort, 22% reached suggested goals for depression and 47% for anxiety.

Conclusions:

CC has benefits for both patients and providers. Patients receive holistic treatment of both mental and physical health needs and access to psychiatric services for medication initiation and behavioral health modalities when necessary. We observed that the CC model improved collaboration with behavioral health specialists and the competence and confidence of family nurse practitioners.
Epilepsy in British Shorthair cats in Sweden
Authors: Tenger Marianne , Van Meervenne Sofie , Varjonen Katarina , Tidholm Anna , Rohdin Cecilia
Published: August 2021

Objectives

The primary objective of this study was to investigate the prevalence of epileptic seizures and of presumed idiopathic epilepsy (PIE, describing epilepsy of unknown origin) in a cohort of British Shorthair (BSH) cats in Sweden. The secondary objective was to describe epileptic seizure characteristics and outcome for cats with PIE.

Methods

Owners of BSH cats born between 2006 and 2016 and registered with SVERAK (the Swedish Cat Clubs’ National Association) were invited to reply to a questionnaire about their cat’s general health. Owners who indicated that their cat had experienced epileptic seizures were invited to participate in an in-depth telephone interview about the epileptic seizures. The clinical characteristics of epileptic seizures in BSH cats were determined from the results of the interview.

Results

In this population comprising 1645 BSH cats (representing 28% of registered BSHs), the prevalence of epileptic seizures was 0.9% and for PIE it was 0.7%. BSH cats with PIE presented with infrequent but consistent epileptic seizures. Twenty-seven percent of BSH cats with epileptic seizures had cluster seizures but none presented with status epilepticus. None of the BSH cats was treated with antiepileptic drugs, and none of the owners reported epileptic seizure remission in their cat.

Conclusions and relevance

The prevalence of PIE in this population of BSH cats was 0.7%. The prevalence of epileptic seizures was 0.9%. In general, PIE in the BSH cat displayed a relatively benign phenotype where progression of epileptic seizures was uncommon.
Filling the vacuum: Role of negative pressure wound therapy in open wound management in cats
Authors: Nolff Mirja C
Published: August 2021

Practical relevance:

Open wounds and their treatment present a common challenge in veterinary practice. Approaching 15 years ago negative pressure wound therapy (NPWT) started to be incorporated into clinical veterinary medicine, and its availability is becoming more widespread in Europe and the USA. Use of this therapy has the potential to significantly increase the healing rate of open wounds as well as free skin grafts in small animals, and it has been occasionally described for the management of feline wounds.

Aim:

This review describes the mechanisms of action of, and indications for, NPWT, and offers recommendations for NPWT specific to feline patients.

Evidence base:

The information presented is based on the current evidence and the author’s clinical experience of the technique gained over the past 12 years. Comparative studies of different treatment options are lacking and, since wound healing in cats and dogs differs, cat-specific studies are especially needed. Well-designed wound healing studies comparing different advanced techniques will improve open wound healing in cats in the future, and potentially allow better understanding of the role of NPWT in this setting.
Quantifying self-quantification: A statistical study on individual characteristics and motivations for digital self-tracking in young- and middle-aged adults in Germany
Authors: Findeis Charlotte , Salfeld Benedikt , Voigt Stella , Gerisch Benigna , King Vera , Ostern Anna Rosa , Rosa Hartmut
Published: August 2021

This study presents a quantitative account of who uses or stops using digital self-tracking (ST). A representative sample of German adults aged 20–50 years ( N = 1022) completed an online survey on their ST practices, personality traits and attitudes toward numbers, on sociodemographic characteristics, mental disorders (particularly bulimia, burnout syndrome, and depression) and somatic disorders. A descriptive statistical analysis was performed on differences between self-trackers and non-trackers. Among others, they differ regarding age, civil status, social class, presence of mental and/or somatic diagnoses, performance-pressure, and strive for competition. A consequent binary logistic regression analysis suggests perfectionism, a somatic diagnosis within the last 5 years, a diagnosis of bulimia in the past, as well as a present mental diagnosis to be significant predictors for ST, though the predictive value of the factors was relatively low.
Provincializing planning: Reflections on spatial ordering and imperial power
Authors: Beebeejaun Yasminah
Published: August 2021

This paper takes the development of the British town planning movement as its starting point to explore a series of challenges for the discipline’s historiography. The emergence of the professional field involved the circulation of ideas beyond the metropolitan core to colonial territories with spatial interventions that were deemed both physically and morally beneficial. The paper explores the role played by the discipline in developing spatialized forms of ethnic and racial differentiation within colonial territories. I conclude that British planning has largely ignored its own historiography, including the colonial legacy, enabling the discipline to assert its role as a socially progressive profession.
Revisiting Lung Cancer Metastasis: Insight From the Functions of Long Non-coding RNAs
Authors: Huang Peng , Zhu Shaomi , Liang Xin , Zhang Qinxiu , Liu Chi , Song Linjiang
Published: August 2021

Globally, lung cancer is the most common cause of cancer-related deaths. After diagnosis at all stages, <7% of patients survive for 10 years. Thus, diagnosis at later stages and the lack of effective and personalized drugs reflect a significant need to better understand the mechanisms underpinning lung cancer progression. Metastasis should be responsible for the high lethality and recurrence rates seen in lung cancer. Metastasis depends on multiple crucial steps, including epithelial–mesenchymal transition, vascular remodeling, and colonization. Therefore, in-depth investigations of metastatic molecular mechanisms can provide valuable insights for lung cancer treatment. Recently, long noncoding RNAs (lncRNAs) have attracted considerable attention owing to their complex roles in cancer progression. In lung cancer, multiple lncRNAs have been reported to regulate metastasis. In this review, we highlight the major molecular mechanisms underlying lncRNA-mediated regulation of lung cancer metastasis, including (1) lncRNAs acting as competing endogenous RNAs, (2) lncRNAs regulating the transduction of several signal pathways, and (3) lncRNA coordination with enhancer of zeste homolog 2. Thus, lncRNAs appear to execute their functions on lung cancer metastasis by regulating angiogenesis, autophagy, aerobic glycolysis, and immune escape. However, more comprehensive studies are required to characterize these lncRNA regulatory networks in lung cancer metastasis, which can provide promising and innovative novel therapeutic strategies to combat this disease.
When the independence of syntactic representation meets the sentence processing of Mandarin: Evidence from syntactic priming
Authors: Xiang Keshu , Chang Hui , Sun Lu
Published: August 2021

There is no consensus on whether syntactic representation is independent of semantic representation in Mandarin. In four experiments, we adopted the syntactic priming paradigm to investigate the independence of syntactic representation in Mandarin. Experiments 1 and 2 investigated the priming effects of double object construction (DO) and prepositional object construction (PO) with the ditransitive verb being repeated across the prime and target. Experiment 1 showed two-way priming effects of DO and PO. Experiment 2 showed that the syntactic priming effects persisted regardless of whether the semantic features (animacy of the Theme) matched across the prime and target or not. Furthermore, such effects persisted in Experiments 3 and 4 where the ditransitive verb across the prime and target was not repeated. Taken together, these findings provide evidence that syntactic/semantic independence is universal and favoured over the traditional Chinese grammar account, which claims that the syntactic representation of Mandarin is not independent of the semantic representation.
Clinically unsuspected primary hepatic mucosa-associated lymphoid tissue lymphoma collision with an intrahepatic cholangiocarcinoma: A case report and literature review
Authors: Grewe Stefanie , Shahid Mohammad , Zhang Ling , Jiang Kun
Published: August 2021

A synchronous tumor represents two histologically distinct neoplasms occurring at the same anatomic site, each displaying a distinct tumorigenesis pathway; they can be primary, secondary, or a mixture. The occurrence of an adenocarcinoma and lymphoma has been reported in gastrointestinal and pulmonary sites; however, such a finding in hepatobiliary system remains elusive. Primary hepatic lymphoma is rare, while primary biliary mucosa-associated lymphoid tissue lymphoma is an even rarer event; hence, its collision with an intrahepatic cholangiocarcinoma could be entirely missed both in practice and in the literature. We herein reported a case of biliary mucosa-associated lymphoid tissue lymphoma occurring synchronously with an intrahepatic cholangiocarcinoma in a 78-year-old female following a biopsy-proven intrahepatic cholangiocarcinoma and hepatectomy. Microscopic examination identified atypical lymphoid population intermingled with this intrahepatic cholangiocarcinoma. An immunohistochemical panel uncovered an incidental mucosa-associated lymphoid tissue lymphoma occurring with this intrahepatic cholangiocarcinoma. This clinically missed entity led to comprehensive systemic investigation/staging, with subsequent detection of bone marrow involvement by stage IV lymphoma. This unique case highlights the importance of astute histomorphological evaluation and thorough ancillary studies in identifying a clinically unsuspected neoplasm in close contact with a known tumor.
Acute motor axonal neuropathy after ipilimumab and nivolumab treatment in melanoma brain metastases: A case report and review of the literature
Authors: Piña Yolanda , Evernden Brittany R. , Khushalani Nikhil , Margolin Kim , Tawbi Hussein , Tran Nam D. , Macaulay Robert , Forsyth Peter , Peguero Edwin
Published: August 2021

The use of immune checkpoint inhibitors including ipilimumab and nivolumab has expanded for several tumors including melanoma brain metastasis. These have resulted in a growing spectrum of neurologic immune-related adverse events, including ones that are rare and difficult to diagnose and treat. Here, we present a patient with melanoma brain metastasis who was treated with immune checkpoint inhibitors and developed an Acute Motor Axonal Neuropathy. To our knowledge, this is the first case of Acute Motor Axonal Neuropathy as an immune-related adverse event associated with combination treatment of ipilimumab and nivolumab, who was successfully treated. A 28-year-old woman with metastatic BRAF V600E melanoma developed melanoma brain metastasis and was enrolled on Checkmate 204, a Phase 2 clinical trial using ipilimumab (3 mg/kg intravenous) and nivolumab (1 mg/kg intravenous) every 3 weeks for four cycles, followed by monotherapy with nivolumab (240 mg intravenous) every 2 weeks. A few days after Cycle 2 of ipilimumab and nivolumab, she developed a pure motor axonal neuropathy consistent with Acute Motor Axonal Neuropathy. She was treated with several immunosuppressive treatments including high dose methylprednisolone, immune globulin, and infliximab, and her motor neuropathy eventually improved several months after onset of symptoms. Unfortunately, she had progression of her systemic disease and died several months later. This is the first case reported of Acute Motor Axonal Neuropathy associated with ipilimumab and nivolumab, successfully treated with immune-suppressive therapy. As the field of immunotherapy expands with the increasing use of the immune checkpoint inhibitors, it is critical to increase our knowledge and understanding of the neurologic immune-related adverse events associated with immune checkpoint inhibitors. This includes the spectrum of rare neurologic immune-related adverse events, which can be quite difficult to recognize and treat. Early consultations with neurology may expedite a diagnosis and treatment plan in patients with unexplained weakness receiving immune checkpoint inhibitor therapy.
From Demotivation to Remotivation: A Mixed-Methods Investigation
Authors: Albalawi Fatemah H. , Al-Hoorie Ali H.
Published: August 2021

Research into language learning demotivation has tended to focus on the identification of discrete factors resulting in demotivation. In this article, we report an investigation into the interrelationship among factors eventually leading to demotivation using a sequential exploratory mixed-methods design. In Study 1, 13 participants were interviewed about their demotivation experiences and what factors, they perceived, had led to demotivation over a period of 12 months. We then used these results to formulate a demotivation model. In Study 2, we tested the generalizability of this model on a larger sample ( N = 2044). Using structural equation modeling, our results showed that the model fit the data, and most of its paths were statistically significant. This model showed that having a fixed mindset had one direct and two indirect paths to demotivation. The two indirect paths were through lowering the learner’s ideal L2 self and through feeling disappointed by setbacks. We discuss the implication of our findings for language learning and teaching.
Epstein-Barr Virus Coinfection in COVID-19
Authors: Nadeem Asim , Suresh Krithika , Awais Hassan , Waseem Saba
Published: August 2021

Epstein-Barr virus (EBV), a member of the herpes virus family, is a causative agent for infectious mononucleosis in young adults. It has an asymptomatic and subclinical distribution in about 90% to 95% of the world population based on seropositivity. EBV is associated with various lymphomas, nasopharyngeal carcinoma, and in immunocompromised states can give rise to aggressive lymphoproliferative disorders. Symptomatic patients mostly present with mild hepatitis, rash, oral symptoms, lymphadenopathy, and generalized malaise. Recently with the COVID-19 (coronavirus disease-2019) pandemic, hepatitis has been found to be related to acute EBV and cytomegalovirus reactivation versus acute infection in the absence of other major causes. We describe a case of EBV coinfection in a patient with resolving mild COVID-19 infection.
Attending to the Adversity of Racism Against Young Black Children
Authors: Iruka Iheoma U. , Durden Tonia R. , Gardner-Neblett Nicole , Ibekwe-Okafor Nneka , Sansbury Amber , Telfer Nicole A.
Published: August 2021

The first 1,000 days is one of the most consequential times for children’s development. As a hugely ignored adversity embedded in all aspects of black children’s lives before birth and throughout their life course, racism in all forms deserves more attention in the developmental science literature. Racism—including structural, institutional, interpersonal, intrapersonal, and cultural—negatively impacts the health, learning, and well-being of black children, their families, and their communities. Using the Integrative Model for the Study of Developmental Competencies for Minority Children and Critical Race Theory frameworks, this article elucidates how racial disparities in every opportunity and outcome connected to black children and their ecosystem are due to white supremacy and anti-black racism. We call for urgent action focused on preservation, protection, and promotion to address white supremacy and combat anti-black racism through racial equity and culturally grounded science and policymaking.
Differences in cerebral small vessel disease magnetic resonance imaging markers between lacunar stroke and non–Lobar intracerebral hemorrhage
Authors: Wiegertjes Kim , Jansen Michelle G , Jolink Wilmar MT , Duering Marco , Koemans Emma A , Schreuder Floris HBM , Tuladhar Anil M , Wermer Marieke JH , Klijn Catharina JM , Leeuw Frank-Erik de
Published: August 2021

Introduction

It is unclear why cerebral small vessel disease (SVD) leads to lacunar stroke in some and to non–lobar intracerebral hemorrhage (ICH) in others. We investigated differences in MRI markers of SVD in patients with lacunar stroke or non–lobar ICH.

Patients and methods

We included patients from two prospective cohort studies with either lacunar stroke (RUN DMC) or non–lobar ICH (FETCH). Differences in SVD markers (white matter hyperintensities [WMH], lacunes, cerebral microbleeds [CMB]) between groups were investigated with univariable tests; multivariable logistic regression analysis, adjusted for age, sex, and vascular risk factors; spatial correlation analysis and voxel–wise lesion symptom mapping.

Results

We included 82 patients with lacunar stroke (median age 63, IQR 57–72) and 54 with non-lobar ICH (66, 59–75). WMH volumes and distribution were not different between groups. Lacunes were more frequent in patients with a lacunar stroke (44% vs. 17%, adjusted odds ratio [aOR] 5.69, 95% CI [1.66–22.75]) compared to patients with a non–lobar ICH. CMB were more frequent in patients with a non–lobar ICH (71% vs. 23%, aOR for lacunar stroke vs non–lobar ICH 0.08 95% CI [0.02–0.26]), and more often located in non–lobar regions compared to CMB in lacunar stroke.

Discussion

Although we obserd different types of MRI markers of SVD within the same patient, ischemic markers of SVD were more frequent in the ischemic type of lacunar stroke, and hemorrhagic markers were more prevalent in the hemorrhagic phenotype of non-lobar ICH.

Conclusion

There are differences between MRI markers of SVD between patients with a lacunar stroke and those with a non-lobar ICH.
Levetiracetam in management of bilateral trigeminal neuralgia due to large glomus tumor case report
Authors: Hsieh Billie , Benkli Barlas , Ansoanuur George N , Bonfante-Mejia Eliana E , Smart Shaun O
Published: August 2021

Background:

Trigeminal neuralgia can be classical or idiopathic. While trigeminal neuralgia (TN) due to space-occupying lesions is atypical, such lesions rarely cause severe TN secondary to trigeminal nerve irritation. Mass effect from these lesions has been shown to correlate with symptom burden, due to direct or indirect compressive effects. A tethering effect, provoked by an abnormal root-stretching force, theoretically plays a role in trigeminal nerve hyperexcitability.

Case:

The likely etiology in this case presentation is a large glomus tumor invading the middle and posterior cranial fossa. Glomus tumors are uncommon benign tumors of the head and neck derived from neural crest cells. Even more strikingly, a large glomus tumor causes bilateral TN due to direct compression on one side and indirect compression on the contralateral side.

Conclusion:

Although the gold standard in TN management is carbamazepine, other anti-epileptic drugs (AEDs) have been used in the treatment of patients unable to take carbamazepine. A few studies suggest levetiracetam alleviates central and neuropathic pain, supporting the hypothesis that it may be effective in management of TN.
A novel method for predicting cell abundance based on single-cell RNA-seq data
Authors: Peng Jiajie , Han Lu , Shang Xuequn
Published: August 2021

Background

It is important to understand the composition of cell type and its proportion in intact tissues, as changes in certain cell types are the underlying cause of disease in humans. Although compositions of cell type and ratios can be obtained by single-cell sequencing, single-cell sequencing is currently expensive and cannot be applied in clinical studies involving a large number of subjects. Therefore, it is useful to apply the bulk RNA-Seq dataset and the single-cell RNA dataset to deconvolute and obtain the cell type composition in the tissue.

Results

By analyzing the existing cell population prediction methods, we found that most of the existing methods need the cell-type-specific gene expression profile as the input of the signature matrix. However, in real applications, it is not always possible to find an available signature matrix. To solve this problem, we proposed a novel method, named DCap, to predict cell abundance. DCap is a deconvolution method based on non-negative least squares. DCap considers the weight resulting from measurement noise of bulk RNA-seq and calculation error of single-cell RNA-seq data, during the calculation process of non-negative least squares and performs the weighted iterative calculation based on least squares. By weighting the bulk tissue gene expression matrix and single-cell gene expression matrix, DCap minimizes the measurement error of bulk RNA-Seq and also reduces errors resulting from differences in the number of expressed genes in the same type of cells in different samples. Evaluation test shows that DCap performs better in cell type abundance prediction than existing methods.

Conclusion

DCap solves the deconvolution problem using weighted non-negative least squares to predict cell type abundance in tissues. DCap has better prediction results and does not need to prepare a signature matrix that gives the cell-type-specific gene expression profile in advance. By using DCap, we can better study the changes in cell proportion in diseased tissues and provide more information on the follow-up treatment of diseases.
Implementation of pharmaceutical services in Brazilian primary health care: a cross-sectional study
Authors: Pereira Nathália Cano , Luiza Vera Lucia , Campos Mônica Rodrigues , Chaves Luisa Arueira
Published: August 2021

Background

In the Brazilian public health system, primary health care (PHC) is provided by the municipalities and is considered the entry level of the Unified Health System (SUS). Governmental pharmaceutical services (PharmSes) are part of the SUS, including PHC, and are the most significant way in which patients access medicine and services. Considering the diversity of the country, the municipalities have the autonomy to decide how PharmSes are implemented. Even though policies and procedures should be implemented as expected by policy makers and experts, municipality characteristics may interfere with implementation fidelity. Therefore, this study evaluated the degree to which the PharmSes in PHC were delivered as intended in Brazilian municipalities.

Methods

We analysed data from a secondary database originating from a cross-sectional nationwide study carried out by the Ministry of Health and the World Bank from 2013 to 2015. Data on 465 municipalities and the Federal District were collected from 4939 governmental PharmSes. A rating system comprising 43 indicators was developed and applied to the dataset to obtain the implementation degree (ID) of each PharmSe. Additionally, the IDs of the two PharmSes dimensions and the nine components were measured.

Results

Overall, the ID of the PharmSes in Brazilian PHC was evaluated as critical. The ID was critical in 81% of the municipalities (n = 369), incipient in 14% (n = 65) and unsatisfactory in 4.8% (n = 22). Regarding the PharmSes dimensions, the ‘medicine management’ (MM) ID was considered critical (Mean = 46%), while the ‘care management’ (CM) ID was incipient (Mean = 22%). In terms of the PharmSes components, the highest ID was achieved by ‘forecasting’ (58%). In contrast, ‘continuing education and counselling’ showed the lowest figure (ID = 11%) in the whole sample, followed by ‘information and communication’ and ‘teamwork’.

Conclusions

The degree to which PharmSes were implemented was critical (ID< 50%). This analysis demonstrated that PharmSes were implemented with low fidelity, which may be related to the low availability of medicine in PHC. Although the care management component requires more attention, considering their incipient ID, all components must be reviewed. Municipalities must increase their investment in PharmSes implementation in order to maximize the benefits of these services and guarantee the essential right of access to medicine.
Pseudomonas otitidis bacteraemia in a patient with COPD and recurrent pneumonia: case report and literature review
Authors: Caixinha Adriana L. , Valsamidis Alexandros N. , Chen Ming , Lindberg Mats
Published: August 2021

Background

Pseudomonas otitidis is a novel species of Pseudomonas bacteria that has been isolated from patients with otic infections.

Case presentation

In this report, we describe a case of a 59-year-old known with moderate chronic obstructive pulmonary disease with bronchiectasis and recurrent pneumonia where blood cultures revealed the growth of P. otitidis.

Conclusions

This case describes the first report of bacteraemia to P. otitidis and raises questions regarding the misdiagnosis and underestimation of the incidence of infections caused by this novel pathogen.