bluuebunny/crossref_metadata_2025 huggingface dataset:
Crack Propagation Law and Failure Characteristics of Coal-Rock Combined Body with the Different Inclination Angle of Prefabricated Fissure
Authors: Zhang Chunlei , Dong Yun , Feng Ruimin , Peng Ningbo , Zhang Jihua , Wu Jingke , Shen Wei
Published: July 2021

Few studies have been conducted on the crack propagation law and failure characteristics of coal-rock combined body (CRCB) with prefabricated fissure. A sliding crack model was firstly presented to analyze the failure law of rock with a single fracture and the influence of the inclination angle of the fracture on the strength of the rock. The RFPA numerical models of the CRCB with different inclination angles of prefabricated fracture were then established to simulate the dynamic change process of crack propagation and shear stress of the CRCB with prefabricated fracture under uniaxial compression. The influence of the inclination angle of the fracture in the rock on the fracture expansion and failure characteristics of CRCB was further analyzed based on the acoustic emission data. The results showed that (1) when

2
β
=
arctan
1
/
μ

,

σ

cw

takes the minimum value, and crack initiation is most likely to occur; (2) the strength of coal-rock assemblage shows different changing trends with the fracture inclination angle; (3) the secondary cracks of CRCB with prefabricated fracture of 0°, 15°, and 30° initiated and expanded near the tip of the main crack, and the secondary cracks of 45°, 60°, and 75° initiated and expanded from the tip of the main crack; (4) there are three failure modes of CRCB with prefabricated crack, the double-shear failure mode

Λ

, the tensile-shear composite failure mode along the fracture surface, and the tensile failure mode along the fracture surface; and (5) intact CRCB and CRCB with prefabricated crack when

α
=

75

°

and

α
=

90

°

have strong brittleness, and other CRCB with different prefabricated fracture inclination angles show a certain degree of postpeak plasticity. The results on the mechanical properties and damage characteristics of CRCB are of great significance for the safety and efficient mining of deep coal resources.
[Retracted] Lineage Contribution of PDGFRα‐Expressing Cells in the Developing Mouse Eye
Authors: Zhuo Deyi , Diao Yumei , Li Xiaoqi , Huang Yifei , Wang Liqiang
Published: July 2021

PDGFRα signaling is critically important in ocular development. Previous data on PDGFRα lacks an expression map with high spatial and temporal resolution and lineage information. In this study, we aim to present a detailed PDGFRα expression and lineage map from early embryogenesis to adulthood. PDGFRα‐CreER; mT/mG reporter mice were analyzed. mEGFP‐positive cells contributed to multiple ocular lineages in a spatiotemporally regulated manner. A dynamic PDGFRα expression was identified in corneal stromal cells, lens epithelial cells, lens fiber cells, and retinal astrocytes during the entire period of eye development, while PDGFRα expression in retinal astrocytes from E17.5 onwards and in Müller glial cells was identified within two weeks after birth. By revealing detailed characterization of gene expression and function, we present a comprehensive map of PDGFRα‐expressing cells in the eye for a better understanding of PDGFRα signaling’s role during eye development.
The Effects of Berberis integerrima Fruit Extract on Glycemic Control Parameters in Patients with Type 2 Diabetes Mellitus: A Randomized Controlled Clinical Trial
Authors: Soltani Rasool , Ghanadian Syed Mustafa , Iraj Bijan , Homayouni Alireza , Esfahani Tanin Shahmiveh , Akbari Mojtaba
Published: July 2021

Background. Berberis integerrima Bunge fruits have been utilized in traditional medicine to control diabetes mellitus (DM). However, no clinical survey has been done in this regard. This study was conducted to clinically evaluate the effects of fruit extract of this plant in improving glycemic control indices in patients with type 2 DM (T2DM). Methods. In a randomized controlled clinical trial, patients with T2DM who met the inclusion criteria were randomly divided into two groups of drug (Berberis) and control to receive the extract solution 5 ml twice daily (equivalent to 1000 mg of dry extract) with standard treatment (metformin) or only standard treatment, respectively, for 8 weeks. Before and after the intervention, fasting blood sugar (FBS), serum glycosylated hemoglobin (HbA1c), serum insulin, the homeostasis assessment model for insulin resistance (HOMA-IR), body mass index (BMI), and systolic and diastolic blood pressure were determined and compared between the two groups. Results. During the study, 30 and 35 patients in the drug and control groups, respectively, completed the study. Although no significant changes occurred in any parameter within each group, postintervention FBS (117.5 [107–128.8] versus 134 [120–142],

P
=
0.001

) and HbA1c (7 [6.4–7.7] versus 7.5 [6.8–7.9],

P
=
0.045

) were significantly lower in the drug group than in the control one. In terms of other parameters, there were no significant differences between the groups. Conclusion. Consumption of B. integerrima Bunge fruit extract at a dosage of 1000 mg daily decreases FBS and HbA1c but does not affect HOMA-IR in patients with type 2 diabetes mellitus.
Diagnostic Accuracy of Procalcitonin for Bacterial Infection in Liver Failure: A Meta-Analysis
Authors: He Xinchun , Chen Liang , Chen Haiou , Feng Yuqing , Zhu Baining , Yang Caixia
Published: July 2021

The purpose of our studies was to systematically assess the accuracy and clinical value of plasma calcitonin in patients with liver failure complicated with bacterial infection. In this study, we included prospective observational studies or randomized controlled trials on PCT. The quality of the studies was evaluated using the Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2) tool. Heterogeneity, pooled diagnostic odds ratio (DOR), pooled sensitivity, pooled specificity, pooled positive likelihood ratio, pooled negative likelihood ratio, the area under the summary receiver operating characteristic curve (SROC), and metaregression analysis were performed using Stata16.0 software. Consequently, the studies revealed substantial heterogeneity (I2 = 96, 95% confidence interval (95% CI) = 94–99). The results of meta-analysis using random effect models suggested that the combined DOR was 10.67 (95% CI = 3.73–30.53). In addition, the threshold effect analysis showed that the threshold effect was 0.23 and the correlation coefficient was −0.48, indicating that there was no threshold effect. In the forest map, the DOR of each study and the combined DOR are not distributed along the same line, and Q = 2.2 × 1014,

P
≤
0.001

. Furthermore, the metaregression analysis of PCT study design, bacterial infection site, and mean age displayed that the

P

values were >0.05. The combined sensitivity was 0.77 (95% CI = 0.54–0.90), the combined specificity was 0.76 (95% CI = 0.70–0.82), the combined positive likelihood ratio was 3.25 (95% CI = 2.33–4.52), the combined negative likelihood ratio was 0.30 (95% CI = 0.14–0.67), and the combined AUC was 0.80 (95% CI = 0.76–0.83). In conclusion, PCT has moderate diagnostic value for adult liver failure complicated with bacterial infection, and it is a better auxiliary diagnostic index for liver failure with bacterial infection. However, the results of procalcitonin must be carefully interpreted combined with medical history, physical examination, and microbiological assessment.
Desmin Correlated with Cx43 May Facilitate Intercellular Electrical Coupling during Chronic Heart Failure
Authors: Cao Junxian , Gao Qianping , Chen Hongyan , Wang Can , Zhang Qiuju , Wang Zhipeng , Li Yuanshi
Published: July 2021

Desmin is one of five major intermediate filament proteins in cardiomyocytes. Desmin contributes to the maintenance of healthy muscle. The desmin content in cardiomyocytes directly affects the long-term prognosis of patients with heart failure, and lack of desmin leads to myocyte contractile dysfunction. However, the mechanism is elusive. In this study, we measured desmin expression using western blotting and qPCR in the failed hearts of human patients and rats. Our results showed that desmin content was reduced at the protein level in failed hearts and isolated cardiomyocytes. The association of desmin and the gap junction proteins connexin 43 (Cx43) and zonula occludens-1 (ZO-1) was also investigated. Immunoprecipitation assay showed that desmin was associated with Cx43 in cardiomyocytes. To compare the electrical integration of skeletal myoblasts in cocultures with cardiac myocytes, familial amyloid polyneuropathy (FAP) activation rate was found in 33% desmin overexpressing skeletal myoblasts. Desmin not only affected Cx43 and ZO-1 expression but also facilitated the complex of Cx43 and ZO-1 in skeletal myoblasts, which enhanced cell-to-cell electrical coupling of skeletal myoblasts with cardiac myocytes. Desmin has potential as a novel therapeutic target for heart failure. Preservation of desmin may attenuate heart failure.
Phase Behavior Identification and Formation Mechanisms of the BZ19-6 Condensate Gas Reservoir in the Deep Bozhong Sag, Bohai Bay Basin, Eastern China
Authors: Wang Zhenliang , Xiao Shengdong , Wang Feilong , Tang Guomin , Zhu Liwen , Zhao Zilong
Published: July 2021

Significant developments have been observed in recent years, in the field of deep part exploration in the Bozhong Sag, Bohai Bay Basin in eastern China. The BZ19-6 large condensate gas field, the largest gas field in the Bohai Bay Basin, was discovered for the first time in a typical oil-type basin. The proven oil and gas geological reserves in the deeply buried hills of the Archean metamorphic rocks, amount to approximately

3
×

10

8

tons of oil equivalent. However, the phase behavior and genetic mechanisms of hydrocarbon fluids are still unclear. In this study, the phase diagram identification method and various empirical statistical methods, such as the block diagram method,

φ

1

parameter method, rank number method, and

Z

-factor method were implemented to comprehensively identify the phase behavior types of the BZ19-6 condensate gas reservoir. The genetic mechanism of the BZ19-6 condensate gas reservoir was investigated in detail through analyses of physical properties of the fluid at high temperatures and pressures, organic geochemical characteristics of condensate oil and gas, and regional tectonic background. Consequently, this study is shown as follows: (1) The BZ19-6 condensate gas reservoir is a part of a secondary condensate gas reservoir with oil rings, formed synthetically since the Neogene period due to multiple factors, such as retrograde evaporation from deep burial and high temperature, inorganic CO2 charging from the deep mantle, and late natural gas invasion. (2) The hydrocarbon accumulation process of the BZ19-6 condensate gas reservoir is as follows: First, a large amount of oil is accumulated at the end of the lower Minghuazhen deposition (5 Ma BP); second, a large amount of natural gas is generated in the deep-source kitchen and mantle-derived inorganic CO2 charged into the early formed oil reservoirs at the end of the upper Minghuazhen deposition (2 Ma BP). As a result, the content of gaseous hydrocarbons in the hydrocarbon system of the reservoir increased, which led to large amounts of liquid hydrocarbons dissolved in gaseous hydrocarbons and significantly reduced the critical temperature of the hydrocarbon system. Therefore, existing secondary condensate gas reservoirs are formed when the critical temperature is lower than the formation temperature and it enters the critical condensate temperature range.
A Review on the Mechanism of Tuina Promoting the Recovery of Peripheral Nerve Injury
Authors: Liu Zhifeng , Wang Hourong , Yu Tianyuan , Jiao Yi , Zhang Yingqi , Liu Di , Xu Yajing , Guan Qian , Lu Mengqian
Published: July 2021

Tuina, as one of the characteristic external therapies of Traditional Chinese Medicine (TCM), has been used to treat the disease caused by peripheral nerve injury (PNI) for thousands of years. An increasing number of clinical trials and animal experiments have demonstrated that tuina can improve the symptoms and promote the recovery of damaged nerves. This review focuses on the mechanistic studies of tuina in promoting the recovery of PNI, which might provide a neurobiological foundation for the effects of tuina. Although many mechanisms underlying the effects of tuina on nerve repair have been identified, there are still many unknown problems, such as the key substance or way for tuina to work, so further investigation is warranted.
Diacerein Inhibits Myopia Progression through Lowering Inflammation in Retinal Pigment Epithelial Cell
Authors: Tien Peng-Tai , Lin Chia-Hung , Chen Chih-Sheng , Chang Ching-Yao , Ku Hsiangyu , Gan Dekang , Tsai Yi-Yu , Chen Jamie Jiin-Yi , Lin Hui-Ju , Wan Lei
Published: July 2021

Myopia is a highly prevalent refractive disorder. We investigated the effect of diacerein on monocular form deprivation (MFD) in hamsters as a possible therapeutic intervention. Diacerein is an anthraquinone derivative drug whose active metabolite is rhein. Diacerein or atropine was applied to the MFD hamsters, and their refractive error and axial length were measured after 21 days. The refractive error (control:

−
0.91
±
0.023

, atropine:

−
0.3
±
0.08

, and diacerein:

−
0.27
±
0.07
 
D

) and axial length (control:

0.401
±
0.017

, atropine:

0.326
±
0.017

, and diacerein:

0.334
±
0.016
 
mm

) showed statistically significant differences between control, atropine-treated, and diacerein-treated MFD eyes. Furthermore, we determined the level of transforming growth factor-beta- (TGF-) β1, matrix metalloproteinase- (MMP-) 2, type I collagen, interleukin- (IL-) 6, IL-8, and monocyte chemoattractant protein- (MCP-) 1 in the retina. Atropine and diacerein suppressed levels of the myopia-related TGF-β1 and MMP-2 while increasing type I collagen expression. They also inhibited the interleukin IL-6, IL-8, and MCP-1 levels. Diacerein reduced the IL-6, IL-8, and MCP-1 expression in ARPE-19 cells. Furthermore, diacerein inhibited inflammation by attenuating the phosphorylation of protein kinase B (AKT) and nuclear factor kappa-light-chain-enhancer of activated B (NF-κB) pathway. This suggests that diacerein has a therapeutic effect on myopia and is a potential treatment option.
On Determining the Critical Path of Activity Network with Normalized Heptagonal Fuzzy Data
Authors: Khalifa Hamiden Abd El-Wahed , Alharbi Majed G. , Kumar Pavan
Published: July 2021

In this research work, an approach to determine the critical path of activity network with normalized heptagonal fuzzy data is proposed. In the proposed model, we attempt to develop a method for solving litigation problems by experts when they share the same information but differ in their opinions. The concepts for a critical path method (CPM) optimization with two kinds of data are as follows: those are to be optimistic and those considered being pessimistic. A numerical example is given for the illustration of the proposed approach and gain more insights. Based on the findings of the proposed work, we observe that the floating times with optimistic data are always smaller than or equal to the corresponding floating times for the pessimistic data.
A Stock Trend Forecast Algorithm Based on Deep Neural Networks
Authors: Yan Yingying , Yang Daguang
Published: July 2021

As a recognized complex dynamic system, the stock market has many influencing factors, such as nonstationarity, nonlinearity, high noise, and long memory. It is difficult to explain it simply through mathematical models. Therefore, the analysis and prediction of the stock market have been a very challenging job since long time. Therefore, this paper adopts an encoder-decoder model of attention mechanism, adding attention mechanism from two aspects of feature and time. Both encoder and decoder use LSTM neural network. This method solves two problems in time series prediction; the first problem is that multiple input features have different degrees of influence on the target sequence, the feature attention mechanism is used to deal with this problem, and the weights of different input features can be obtained. A more robust feature association relationship is obtained; the second problem is that the data before and after the sequence have a strong time correlation. The time attention mechanism is used to deal with this problem, and the weights at different time points can be obtained to obtain more robustness and good timing dependencies. The simulation and experimental results show that the introduction of the attention mechanism can obtain lower forecast errors, which proves the effectiveness of the model in dealing with stock forecasting problems.
Experimental and Numerical Research on Defective Shield Segment under Cyclic Loading
Authors: Tian Long-gang , Hu Zhi-qiang , Chen Jie
Published: July 2021

The retaining structure of a shield tunnel is usually subjected to static loading; however, cyclic loading such as the vibration loading of the train will act on the lining structure year after year that cannot be neglected. Due to the complex manufacturing and assembling process of the lining segment, initial defects in the segment are inevitable. Such defects will propagate under the cyclic loading such as the train vibration, which may cause a large threat to the shield tunnel system. In this paper, a defective shield tunnel lining segment under cyclic loading is studied by both a full‐scale experiment and three‐dimensional numerical simulations to investigate its fracture properties and failure mechanism and make a rational estimate of its fatigue life. Results show that crack propagation of the defective shield tunnel segment can be identified as several different stages based on its deformation characteristics, and the failure pattern of the segment is determined by its initial defects. The results by the experiment and numerical investigation are in good agreement for each other.
Pore Structure and Fractal Character of Lacustrine Oil-Bearing Shale from the Dongying Sag, Bohai Bay Basin, China
Authors: Zhang Pengfei , Lu Shuangfang , Zeng Zhiping , Chang Xiangchun , Li Junqian , Chen Guo , Zhang Junjian , Lin Zizhi , Li Jijun
Published: July 2021

To better understand the pore structure and fractal character of lacustrine shales and their influence on liquid hydrocarbon occurrences, in this study, a total of 29 lacustrine oil-bearing shale samples collected from the Shahejie Formation in the Dongying Sag, Bohai Bay Basin, were investigated based on nitrogen adsorption (NGA) analysis combined with TOC, Rock-Eval pyrolysis, X-ray diffraction (XRD), and field emission-scanning electron microscopy (FE-SEM) experiments. The relationships among the compositions (TOC, minerals, and oil content), pore structures, and fractal dimensions of the lacustrine shale samples were discussed. The results showed that the adsorption and fractal characteristics of lacustrine oil-bearing shales differ at relative pressures of 0-0.1 and 0.5-1. Two corresponding fractal dimensions

D

1

and

D

2

were determined by the FHH model according to the nitrogen adsorption branches. Specifically,

D

1

varies from 2.4292 to 2.6109 (mean 2.5245), and

D

2

varies between 2.4680 and 2.8535 (mean 2.6889). The specific surface area (SSA) ranges from 1.512 m2/g to 34.002 m2/g, with an average of 13.656 m2/g, the total pore volume is between 6.0 × 10-3 cm3/g and 48.4 × 10-3 cm3/g (mean 24.5 × 10-3 cm3/g), and the average pore diameter is in the range of 4.22 nm to 19.57 nm (mean 9.35 nm). Both

D

1

and

D

2

increase with increasing SSA and increase with decreasing average pore diameters but have no correlation with pore volume. Moreover,

D

1

and

D

2

exhibit positive relationships with clay minerals and negative correlations with carbonate minerals (calcite and dolomite). The relationship between fractal dimensions (

D

1

and

D

2

) and TOC contents is expressed as a U-shaped curve, characterized by the minimum

D

values at approximately 3% TOC. The shale oil content is controlled by the pore structures and fractal dimensions, and lacustrine shales with lower SSAs and smaller fractal dimensions would have more free oil. Therefore, lacustrine shales in the oil window with TOC contents ranging from 2% to 4% are probably the preferred shale oil exploration target in the Shahejie Formation, Dongying Sag, Bohai Bay Basin. The results indicate that fractal analysis can provide insight into the pore structure characteristics and oil storage capacity of lacustrine shales.
The Current Situation and Influencing Factors of the Alarm Fatigue of Nurses’ Medical Equipment in the Intensive Care Unit Based on Intelligent Medical Care
Authors: Zhao Yunxia , Wan Minlin , Liu Huisong , Ma Mei
Published: July 2021

After rapid development and reform, the health level and medical diagnosis and treatment capabilities of Chinese residents have been significantly improved, and high-quality medical resources have significantly improved the life safety and health of the masses. As the most concentrated area of medical equipment in the hospital, the intensive care unit produces the most alarms during the operation of the equipment. The intensive care unit nurses are responsible for heavier nursing work, and the problem of alarming in other departments is more prominent. Therefore, this paper presents an analysis and research on the current situation and influencing factors of the alarm fatigue of nurse medical equipment in the intensive care unit based on intelligent medicine. This article uses a variety of related methods such as literature data method and questionnaire survey method to deeply study the theoretical knowledge of intelligent medical treatment, medical equipment alarm fatigue device, and so on. The logistic regression analysis method is introduced to classify its influencing factors, and the analysis experiment on the influencing factors of the medical equipment alarm fatigue of nurses in the intensive care unit is designed. The nurses’ cognition of clinical alarms and the analysis of clinical alarm fatigue questionnaire data are studied. The alarm fatigue of nurses in the intensive care unit is at a severe level, which needs to be taken seriously in the intensive care unit. Unmarried, high-level positions, long working years, high professional titles, and high education are negatively correlated with alarm fatigue (

P
<
0.05

), and those without an alarm habit are positively correlated with alarm fatigue (

P
<
0.05

), and the number of night shifts per month is related to alarm fatigue. There is no correlation between them (

P
>
0.05

).
Secondary Normal-Pressure Hydrocephalus in Rheumatoid Meningitis
Authors: Owens Micaela , Gatson Na Tosha , Mongelluzzo Gino , Goren Oded , Newman Eric , Sandulescu Mihai Cosmin
Published: July 2021

Normal-pressure hydrocephalus (NPH) is a common cause of gait apraxia, cognitive impairment, and urinary incontinence in the elderly. It is usually a primary idiopathic disorder but can be secondary. We present a case of secondary NPH due to biopsy-confirmed rheumatoid meningitis initially refractory to intravenous (IV) immunotherapy. Our patient reported an excellent response right after shunting. Her gait remains normal one and a half years later. We searched PubMed for similar cases of rheumatoid meningitis with gait abnormality for additional clinicopathologic discussion. The patient’s movement disorder initially improved with steroid taper. However, she developed progressive symptoms, later on, refractory to IV solumedrol and rituximab. She underwent ventriculoperitoneal shunting (VPS) and reported an outstanding outcome. This is the first reported biopsy-confirmed case of rheumatoid meningitis causing NPH to undergo shunting for immediate improvement. Previous cases of rheumatoid meningitis-associated Parkinsonism have improved with steroid induction. Although our patient’s rheumatoid arthritis is now controlled, her case illustrates that NPH in autoinflammatory conditions may not recover with immune suppression alone. VPS is an option for a faster response in secondary NPH due to rheumatoid meningitis or other inflammatory disorders with progressive symptoms despite standard induction therapy.
A Educação Física no Ensino Médio no “Currículo da Cidade de São Paulo”: uma leitura crítica
Authors: Vaz Antonio Carlos
Published: July 2021

O artigo trata de uma leitura crítica do currículo da rede pública municipal para o Ensino Médio, produzido a partir da Base Nacional Comum Curricular, a ser finalizado no ano de 2020. O documento curricular apresenta um caráter progressista, mostrou-se de fácil manuseio para consulta das professoras e dos professores da rede municipal da cidade de São Paulo. Do ponto de vista dos processos formativos, parece haver uma grande demanda também por discussões de caráter filosófico, para que a proposta possa ser plenamente compreendida e implementada pelo conjunto docente. O documento traz uma fundamentação teórica marcadamente crítica em relação à sociedade contemporânea. Sua estrutura assemelha-se à da Base Nacional Curricular, trazendo a Educação Física dentro do campo de Linguagens e suas tecnologias.
Taxonomic study of the genus Promalactis Meyrick, 1908 (Lepidoptera: Oecophoridae) XI. The rubra species-group and the fuscimacularis species-group, with descriptions of six new species
Authors: WANG SHUXIA , LIU CHEN
Published: July 2021

The rubra and the fuscimacularis species-groups of the genus Promalactis Meyrick, 1908 are proposed for the first time based on the forewing patterns. Moths of the rubra species-group are characterized by the ochreous forewing of all shades with a short dorsal spot or a short obliquely inward dorsal streak; moths of the fuscimacularis species-group are characterized by the forewing having a dark basal spot or a dark basal costal patch. Six species are described as new: P. albimarginalis Wang, sp. nov., P. introextensa Wang, sp. nov., P. magnisticta Wang, sp. nov., P. anteromacularis Wang, sp. nov., P. fuscimacularis Wang, sp. nov., P. folivalvaris Wang, sp. nov. Photographs of adults and genitalia of the new species are provided. A list of species belonging to both species-groups is given.
Research on Autophagy of Gingiva Epithelial Cell Induced by Porphyromonas Gingivalis Regulated by Long Non-Coding RNA Transforming Growth Factor Beta-2 Overlapping Transcript 1 (LncRNA TGFB2-OT1)
Authors: Lin Yujiao , Wang Youshan , Lin Jiaxu , Xie Yiwen
Published: July 2021

Our study analyzes lncRNA TGFB2-OT1’s effect on autophagy and migration of gingiva epithelial cells and porphyromonas gingivalis. The expression of TGFB2-OT1 and TIMP2 in GEC cells was detected by QRT-PCR. Cell proliferation and colon formation was assessed by MTT method and colony forming assay. The relation between TGFB2-OT1 and TIMP2 was confirmed luciferase assay. The autophagy, apoptosis rate and period distribution was detected by flow cytometry along with analysis of porphyromonas gingivalis of GEC cells. TGFB2-OT1 was upregulated significantly as shown by IncRNA array. TGFB2-OT1 overexpression in GEC cells improved cell proliferation and migration, enhanced the sensibility of gingiva epithelial cell on the porphyromonas gingivalis and increased autophagy. The GEC cells were blocked at G2/M period. The TIMP2 was a direct target of TGFB2-OT1. In conclusion, TIMP2 participates in the up-regulation of MMP10 induced by TGFB2-OT1. The lncRNA TGFB2-OT1 maybe be a potential biomarker to assess the autophagy of gingiva epithelial cell.
Research on Anti-Tumor Nano-Particle with New Type 5-Fluorouracil on the Peritoneal Metastasis of Breast Cancer
Authors: Xiao Yujie , Huang Guilin , Xiang Yibo
Published: July 2021

The 5-fluorouracil (5-FU) was a classical chemotherapy drug. The administrational carrier of nano-particle provides enhancement effect prior to target and reduce side effect. But the specific function of nano-particle on the peritoneal metastasis of breast cancer was poorly understood.
Our study was designed to discover the biological function of anti-tumor nano-particle with new type 5-FU on breast cancer. The nano-particle of 5-fluorouracil (5-FU-NPs) was prepared by multiple emulsion method. The distribution of particle size was analyzed by electron microscope. The proliferation
and apoptosis of cell in breast cancer was interfered by 5-FU solution (control group) or 5-FU-NPs. Cell cycle was assessed by flow cytometry and proliferation was detected by MTT and cell clone technology. The rat was injected with 5-FU solution (control group) or 5-FU-NPs intraperitoneally
followed by analysis of tumor volume and size. The average tumor diameter was 200±10.84 nm. The encapsulation rate and loading rate was 81.6±5.7% and 7.29±0.14% respectively. The apoptosis of MCF-7 cell treated by 5-FU-NPs was increased significantly with abundant rounded
and floating apoptotic cellular morphology as well as reduced quantity of surviving cells. The number of bacterial colony induced by 5-FU-NPs, which could interdict cell cycle. The 5-FU-NPs could restrain tumor cell growth in peritoneal metastasis of breast cancer. The new-type nano-particle
of 5-FU loaded with PEG-PLGA could retard breast cancer cell proliferation and peritoneal metastasis of breast cancer in rats.
Cisplatin and si-Notch 1-Folic Acid-Conjugated Mesoporous Silica Nanoparticles Prevent Hepatocellular Carcinoma
Authors: Li Xiaoping , Liu Donghong , Fan Kai , Qian Miaomiao
Published: July 2021

Hepatocellular carcinoma (HCC) is still a severe disorder with a high mortality and new effective therapies are urgently required. Our study aimed to explore the effect of combined cisplatin with conjugated mesoporous silica nanoparticles (MSN) on HCC. We prepared copolymer PCL-b-PPEEA
and PEG-b-PCL-Pt(IV) to load drugs, while Pt(IV) MNP/siRNA nanoparticles were synthesized. The nanoparticles were characterized by transmission electron microscopy and Western blot analysis. Flow cytometry was determined to detect apoptosis of CD133 + SMMC7721 cells. Then cells were treated
with Pt(IV) MNP/siRNA, MNP/siRNA or PBS, where the Notch1 and related gene expression were determined by RT-qPCR with clone formation detected by agarose assay. The synthesized nanoparticles were about 90 nm and absorbed by cancer cells with a high stability. Compared with the cisplatin, Pt(IV)
MNP/siNotch1 nanoparticles exhibited enhanced cytotoxicity and downregu-lated expression of cisplatin-induced Notch1 and cancer stem cells. Moreover, the MNP/siNotch1 nanoparticles significantly suppressed the proliferation and clonal formation of CD133 + SMMC7721 cells. Co-delivery of cisplatin,
si-Notch1 and folic acid conjugated MSN can inhibit the development of HCC, indicating that it might be a novel treatment approach for HCC in the future.
Effects of MicroRNA-22 (miR-222) on Non-Small-Cell Lung Carcinoma (NSCLC) Cells Apoptosis and Proliferation Through Protein Kinase B/Mammalian Target of Rapamycin (AKT/mTOR) Signaling Pathway
Authors: Xie Xiaowei , Lin Jiansheng , Kang Mingqiang , Guo Ying
Published: July 2021

Our study investigated miR-222’s effect on NSCLC apoptosis and proliferation. H1650 cells were assigned into NSCLC group, SI group and IN group followed by analysis of Akt-mTOR protein content, cell apoptosis and proliferation, and miR-222 expression by Western blot, Hoechst 33258
fluorescence staining, qRT-PCR, cck-8, and immunohistochemistry miR-222 expression was lowest in IN group and highest in SI group (P < 0.05). The nucleus shrinkage rate in IN group and NSCLC group was significantly higher than that in SI group (P < 0.05) with NSCLC group
showed more cells apoptosis than IN group (P < 0.05). The SI group had significantly higher OD value than IN group and NSCLC group (P < 0.05) with NSCLC group having significantly higher OD value than IN group (P < 0.05). The Akt-mTOR and p-Akt/p-mTOR expression
was lowest in IN group and highest in SI group (P < 0.05) with lower level in IN group than NSCLC group (P < 0.05). The number of positive Akt-mTOR of H1650 cells was highest in SI group while lowest in IN group (P < 0.05). The decreased miR-222 expression in
NSCLC can promote cancer cell apoptosis and inhibit lung cancer development, which may be via down-regulating Akt-mTOR signaling.
The Targeting Mechanism of Long Intergenic Non-Coding RNA 01503 to miR-338-3p and Its Regulation on Cell Behaviors of Bladder Cancer T24 Cells
Authors: Wu Tingming , Fu Shibao , He Shuming , Che Xianping , Mo Zhibo
Published: July 2021

This study aimed to investigate the effects of long intergenic non-coding RNA 01503 (LINC01503) on cell behaviors of T24 bladder cancer cells, including proliferation and apoptosis, as well as its mechanism for targeting miR-338-3p. First, bladder cancer tissues and the corresponding
adjacent tissues were obtained and subjected to RT-qPCR to analyze their LINC01503 and miR-338-3p expressions. Afterward, si-LINC01503, miR-338-3p mimics were transfected into T24 cells and then CCK-8 assay and flow cytometry were applied to analyze the cell behaviors of the T24 cells, including
proliferation and apoptosis. In additionally, Western blot was carried out to analyze the protein expressions of Ki-67, Bcl-2, and Bax. Finally, dual luciferase reporter and RT-qPCR assay were used to confirm the targeted function of LINC01503 to miR-338-3p. Our data clearly demonstrates a
highly expressed LINC01503 and a lowly expressed miR-338-3p in bladder cancer. Interfering LINC01503 was found to obviously influence some protein expressions, such that it down-regulated Ki-67 and Bcl-2 expressions, but upregulated Bax expression, thus resulting in reduced proliferation and
enhanced apoptosis. Meanwhile, miR-338-3p overexpression was found to influence these protein expressions, which was similar to functions of the interfering LINC01503. Furthermore, it was found that LINC01503 directly binds to miR-338-3p and that LINC01503 overexpression could obviously down-regulate
miR-338-3p expression, thus weakening the influence of interfering LINC01503 on behaviors of the T24 cells. Our results demonstrate that interfering LINC01503 could affect cell behaviors of T24 bladder cancer cells, inhibit proliferation, and induce apoptosis, which was mediated by the targeted
binding of interfering LINC01503to miR-338-3p.
Effect of Huangqin Decoction on Improving the Mouse Model of Ulcerative Colitis by Inhibiting NF-κB p65 Signal Pathway
Authors: Wang Yinyu , Zheng Chenxi , Cheng Ningning , Sun Cong
Published: July 2021

Natural medicine, such as traditional Chinese medicine, plays a role in treating ulcerative colitis (UC) because of its action on multiple targets. Here we have improved the effectiveness of a traditional Chinese medicinal herb, Huangqin decoction (HQD), on UC via the nuclear factor-κB
(NF-κB) p65 signaling pathway in a mouse model. NF-κB is a crucial regulator of inflammation, cancer, and autoimmunity. It may be related to the initiation and development of UC. Histopathological changes in colon show that Huangqin Decoction can improve colon tissue
environment In addition, the Western blots of the inflammatory cytokines related to the NF-κB p65 pathway suggest that HQD inhibits the development of UC by regulating the NF-κB p65 signaling pathway. These findings provide a basis for the clinical application of
HQD and suggest a new strategy for treating UC in the future.
Cost of Futile ICU Care in One Ontario Hospital
Authors: Schouela Nicholas , Kyeremanteng Kwadwo , Thompson Laura H. , Neilipovitz David , Shamy Michel , D’Egidio Gianni
Published: July 2021

Critical care is a costly and finite resource that provides the ability to manage patients with life-threatening illnesses in the most advanced forms available. However, not every condition benefits from critical care. There are unrecoverable health states in which it should not be used to perpetuate. Such situations are considered futile. The determination of medical futility remains controversial. In this study we describe the length of stay (LOS), cost, and long-term outcomes of 12 cases considered futile and that have been or were considered for adjudication by Ontario’s Consent and Capacity Board (CBB). A chart review was undertaken to identify patients admitted to the Intensive Care Unit (ICU), whose care was deemed futile and cases were considered for, or brought before the CCB. Costs for each of these admissions were determined using the case-costing system of The Ottawa Hospital Data Warehouse. All 12 patients identified had a LOS of greater than 4 months (range: 122-704 days) and a median age 83.5 years. Seven patients died in hospital, while 5 were transferred to long term or acute care facilities. All patients ultimately died without returning to independent living situations. The total cost of care for these 12 patients was $7 897 557.85 (mean: $658 129.82). There is a significant economic cost of providing resource-intensive critical care to patients in which these treatments are considered futile. Clinicians should carefully consider the allocation of finite critical care resources in order to utilize them in a way that most benefits patients.
Path planning of mobile robot with PSO-based APF and fuzzy-based DWA subject to moving obstacles
Authors: Lin Zenan , Yue Ming , Chen Guangyi , Sun Jianzhong
Published: July 2021

This paper proposes a two-layer path-planning method, where an optimized artificial potential field (APF) method and an improved dynamic window approach (DWA) are used at the global and local layer, respectively. This method enables the robot to plan a better path under a multi-obstacle environment while avoiding the moving obstacles effectively. For the part of global path planning, a new repulsive field is proposed based on the APF method. The length and smoothness of the global path are taken as fitness functions of particle swarm optimization (PSO) to obtain the obstacle influence range, the coefficients of gravitation and repulsion in APF. At the level of local path planning, on the basis of DWA, a fuzzy control scheme is adopted to evaluate the danger level of moving obstacles via collision risk index and relative distance. In brief, compared with existing methods, the robot can reasonably plan a shorter and smoother path with the aid of PSO-based APF, meanwhile quickly react to the moving obstacles and avoid them by fuzzy-based DWA. Finally, a static multi-obstacle environment and two dynamic scenarios with moving obstacles are simulated to verify the effectiveness of the proposed path-planning method.
Older Persons in Biblical Texts: Using Modern Gerontological Theories to Cast Light and Raise Questions on Four Older Persons in Luke 2
Authors: Dickie June F.
Published: July 2021

In the ancient world, the average life expectancy was far lower than that in the western world today. There are some biblical characters, however, even in the New Testament, who lived into their 80s and beyond. In this article, modern theories of gerontology are examined to indicate questions to ask, and insights to gain, in seeking to understand four such persons of mature years who are briefly mentioned in Luke’s Gospel but who play critical roles in the biblical story. The wisdom available to them on coping with the latter years (as seen in the “aging poem” in Ecclesiastes 12:1–7) is reviewed to assess whether those values are apparent in these four characters, and to compare it with modern ideas.
Parents’ Emotional Responses to Early Parenthood
Authors: Sanders Rachael , Lehmann Jennifer , Gardner Fiona
Published: July 2021

Early parenthood is a significant developmental stage that involves abrupt and dramatic changes to a new parent’s life. It is thought to be both a stressful and rewarding period, requiring significant adjustment to pre-parenthood lifestyles and routines. This study explores the emotional journey that new parents experience during the early phases of parenthood, examining these with a critical lens and giving consideration to the impacts of social constructions on early parenthood. Thirty parents were interviewed as part of a grounded theory study which uncovered parents’ experiences of significant emotional disturbance including self-doubt, isolation and loneliness. Both the role (lack of sleep, frustration) and social expectations and demands contributed to emotional disturbance. Many parents experienced a culture of comparison, competition and judgement that impacted on their emotional well-being, which we believe can be resisted with professional and social supports and the application of critical reflection.
A Qualitative Exploration of Fathers’ Antenatal and Postnatal Challenges
Authors: Gemayel Daisy J. , Wiener Karl K. K. , Nic Giolla Easpaig Bróna , Saliba Anthony J.
Published: July 2021

This study explores and identifies the different challenges for both antenatal and postnatal fathers that might act as precursors for poor paternal perinatal emotional well-being. Twelve fathers living in Sydney, aged over 18 years, identified as either an antenatal or postnatal father were interviewed concerning their experiences. Interview data were thematically analysed to identify challenges faced by expectant and new fathers. Five main challenges were identified – father–mother relationship, father–child relationship, life changes, lack of support and birth event. The results of this study indicate possible differences between antenatal and postnatal challenges, with postnatal fathers being confronted by additional challenges. These findings provide valuable insight for health professionals to better target treatment interventions by considering the actual precursors for poor emotional well-being in fathers.
Organizational and individual barriers and facilitators to the integration of pediatric palliative care for children: A grounded theory study
Authors: Laronne Anat , Granek Leeat , Wiener Lori , Feder-Bubis Paula , Golan Hana
Published: July 2021

Background:

Pediatric palliative care has established benefits for children with cancer and their families. Overcoming organizational and healthcare provider barriers have been demonstrated as central for the provision of palliative care in pediatric oncology. A deeper understanding is needed of the influence of these barriers and the interactions between them, specifically in primary palliative care in hospital settings.

Aim:

To identify the organizational and healthcare provider barriers to the provision of primary pediatric palliative care.

Design:

This study utilized the grounded theory method. Semi-structured interviews were conducted and analyzed line by line, using NVivo software.

Setting/participants:

Forty-six pediatric oncologists, nurses, psychosocial team members, and other healthcare providers from six academic hospital centers participated in the research.

Results:

Organizational and healthcare provider factors were identified, each of which acted as both a barrier and facilitator to the provision of pediatric palliative care. Organizational barriers included lack of resources and management. Facilitators included external resources, resource management, and a palliative care center within the hospital. Individual barriers included attitudes toward palliative care among pediatric oncologists, pediatric oncologists’ personalities, and the emotional burden of providing palliative care. Facilitators include dedication and commitment, initiative, and sense of meaning. Provider facilitators for palliative care had a buffering effect on organizational barriers.

Conclusion:

Organizational and healthcare provider factors influence the quality and quantity of palliative care given to children and their families. This finding has implications on interventions structured to promote primary palliative care for children, especially in healthcare systems and situations where resources are limited.
Interpretative Frames, Phenomenology, and the Question of the Republican Character of Polish and Czech Dissident Movements of the 1970s and 1980s
Authors: Ciżewska-Martyńska Elżbieta
Published: July 2021

The Polish Solidarity movement of 1980–1981 and the Czechoslovak dissident movement both developed an original model of democracy. The dissidents sought to reconcile the tensions between the individual and the community—personal independence and engagement with public affairs—by building a pluralist, debating civic community entrenched in objective values. Calling upon on the phenomenological tradition and the interpretative frames perspective used in social movement studies, the author seeks to interrogate the intellectual roots of the dissident vision of democracy and the reasons behind one of its future interpretations, which viewed it through the lens of the republican political tradition. Drawing on the popularity and the character of the phenomenological tradition, the author explains the differences in the understanding of community in Poland and Czechoslovakia.
The Idea of the Yugoslav–Bulgarian Federation at the End of the Second World War
Authors: Ivašković Igor
Published: July 2021

The article analyses the issue of Yugoslav–Bulgarian unification within the broader idea of a Balkan (con)federation from the aspects of internal and external stakeholders. The author describes the key interwar factors and events impacting the formation of states in postwar South-east Europe and, building on this, identifies the primary motives for/against the idea of a Balkan (con)federation with respect to the Communist Party of Yugoslavia, the Bulgarian Communist Party (BCP), the United Kingdom, and the Soviet Union. In the second part, the role of this idea during the period of Yugoslav and Bulgarian rapprochement immediately after the war is analysed and the major events determining the dramatic turnaround in the Bulgarian–Yugoslav relationship in 1948, when the idea was abandoned, are presented. It is argued that the Yugoslav side tried to take advantage of the (con)federal idea to manoeuvre between the Soviet Union and the United Kingdom, which on the other hand were never very keen on a Yugoslav–Bulgarian state. The BCP showed somewhat greater interest, primarily due to the Macedonian issue. Bulgaria had to follow Moscow’s policy almost entirely, hoping this would lead to Soviet support in obtaining anti-fascist ally status and resolving internal problems with the Bulgarian opposition. From this perspective, promoting the (con)federative alliance with Yugoslavia was the Bulgarian communists’ strategy for accomplishing the nationalistic aim of not completely losing Macedonia. Provided Bulgaria would be an equal part of the dual federation, the BCP had no problem even ceding Pirin Macedonia to the unified socialist Republic of Macedonia.
Prosociality Beyond Big Five Agreeableness and HEXACO Honesty-Humility: Is Openness/Intellect Associated With Cooperativeness in the Public Goods Game?
Authors: Lawn Erin C. R. , Zhao Kun , Laham Simon M. , Smillie Luke D.
Published: July 2021

Who is cooperative? Although Big Five (B5) Agreeableness and HEXACO Honesty-Humility are correlates of charitable prosociality, distinctions between “charity” and “cooperation” suggest that additional traits could be associated with cooperative prosociality. Echoing prior theoretical and empirical indications that B5 Openness/Intellect may play a role in cooperation, Study 1 ( N = 119; exploratory) revealed a significant correlation between Openness/Intellect and cooperativeness in the one-shot Public Goods Game that did not generalize to charitableness in the Dictator Game. We therefore conducted three preregistered replications to discern the robustness of this Openness/Intellect–cooperativeness link. As expected, Openness/Intellect showed no consistent correlation with charitable behavior. Surprisingly, the predicted correlation between Openness/Intellect and cooperative behavior was also inconsistent, partially replicating in Study 3 ( N = 304) but not Studies 2 or 4 ( Ns = 131; 552). Across our replications, cooperative behavior was most strongly correlated with Honesty-Humility (internal meta-analytic [Formula: see text] = .15, p = .005). The correlation between Openness/Intellect and cooperative behavior across our replications was significant and identical in magnitude to that between Agreeableness and cooperative behavior, though this effect-size was weak (internal meta-analytic [Formula: see text] = .08, p < .001). We therefore conclude that Openness/Intellect is a nonnull but very modest correlate of cooperativeness.