bluuebunny/crossref_metadata_2025 huggingface dataset:
O projeto político-pedagógico e currículo da EFAU: educação para que? E para quem?
Authors: Amaral Ana Paula do , Machado Ilma Ferreira
Published: July 2021

Este trabalho tem por objetivo analisar os pressupostos ontológicos, a ideologia e a efetivação diária do Projeto político-pedagógico da Escola Família Agrícola de Uirapuru-GO (EFAU) e sua relação com o currículo diferenciado proposto pela Pedagogia da Alternância, em que os tempos e espaços educativos não se dão exclusivamente na escola, mas também nas comunidades rurais. Sendo assim, buscou-se socializar dados de um projeto de pesquisa que procurou analisar a configuração da Pedagogia da Alternância na EFAU, seus limites e potencialidades, baseando-se em uma metodologia de pesquisa qualitativa, numa perspectiva participante. Nesse processo investigativo, entrevistou-se educadores, estudantes, funcionários/monitores e pais, observando de forma participativa o cotidiano da escola, além de analisar documentos históricos, como o Projeto político-pedagógico (PPP) e Regimento Escolar. Em específico, as correlações entre o PPP e currículo buscam sistematizar e socializar as falas dos educadores e suas reflexões sobre a Pedagogia da Alternância no cotidiano da escola, no sentido de contribuir para ações e debates no âmbito da Educação do Campo.
A integração das tecnologias de informação e comunicação na escola: o projeto político pedagógico nesse contexto
Authors: Castro Márcia Ferreira de , Lemes Sebastião de Souza
Published: July 2021

O presente trabalho tem como objetivo analisar as possibilidades de integração das novas tecnologias de informação e comunicação (TIC) no processo de ensino-aprendizagem em uma escola de Ensino Fundamental da Rede Municipal de Araraquara. Trata-se de uma pesquisa fundamentada numa abordagem qualitativa, que tem como estratégia o Estudo de Caso. Fez-se uma análise das Diretrizes Curriculares e do Projeto Político Pedagógico (PPP) da escola selecionada, com o intuito de verificar como a escola aborda o tema do uso das novas tecnologias no processo educativo. Pela análise feita das Diretrizes Curriculares e do Projeto Político Pedagógico constatamos que a escola estudada tem uma preocupação em fazer uso das TIC no processo de ensino e aprendizagem, o que caracteriza uma conscientização da importância das tecnologias na educação, porém não descreve formas de integrá-las curricularmente. A integração das novas tecnologias no currículo exige uma reflexão sistemática acerca de seus objetivos, de suas técnicas e dos conteúdos escolhidos. Não é somente trabalhar com as novas tecnologias visando à inclusão digital dos alunos, mas é preciso que a escola as integre nas atividades curriculares, ou seja, integrá-las ao processo de ensino e aprendizagem. Hoje as TIC se configuram em uma nova forma de linguagem, essencial para a representação do conhecimento e, nesse caso, sua presença no currículo escolar é fundamental.
Indícios de criatividade e inovação no processo de formação continuada
Authors: Pinho Maria José de , Morais Maria José da Silva , Santos Jocyléia Santana dos
Published: July 2021

Este artigo objetivou identificar, por meio de documentos e relatos de professores da Secretaria Municipal da Educação de Palmas, os indícios de prática criativa e inovadora no processo de formação continuada dos professores dos anos iniciais do ensino fundamental. Este trabalho caracteriza-se como abordagem qualitativa, com caráter exploratório. Os procedimentos técnicos adotados para a realização deste estudo incluem revisão bibliográfica, análise documental e pesquisa de campo (entrevistas). Para haver mudanças nas práticas metodológicas faz-se imprescindível a percepção docente de que o conhecimento é um contínuo aprender. Portanto, ao investigar as experiências pessoais e educacionais de professores, buscou-se evidenciar a memória e a subjetividade desses sujeitos, no sentido de desvelar possibilidades de ações criativas e inovadoras no processo educacional.
Educação especial: compreendendo a produção do conhecimento com a teoria da complexidade
Authors: Antonioli Camyla , Pavão Sílvia Maria de Oliveira
Published: July 2021

O artigo objetiva estabelecer relações entre a produção do conhecimento em educação especial e os métodos de pesquisa nessa área de estudos. Ao encontro do debate proposto e como fio condutor para uma análise qualitativa, a fundamentação teórica apresenta conhecimentos da Teoria da Complexidade (MORIN, 2000, 2005). A produção do conhecimento em educação especial cresce quantitativamente principalmente após a vigência das atuais políticas educacionais, como consequência disso, foi expandida a utilização de métodos de pesquisa. O debate proposto é descrito como um desafio, pois não se deixa por saciar, sendo assim compreendido como constante e emergente.
Campo do poder, refração política e legislação educacional: notas para uma discussão da gestão democrática no Brasil
Authors: Santos Pablo Silva Machado Bispo dos
Published: July 2021

O presente artigo possui como finalidade principal analisar a Política e a Legislação Educacional a partir de um viés ainda pouco explorado, especialmente quando se trata de fenômenos intrincados e que envolvem diversas mediações, Entre estas podemos destacar as mediações jurídico-políticas e sociais. Um elemento exemplar desta ocorrência é a noção de Gestão Democrática, presente na atual Constituição Federal de 1988 (BRASIL, 1988) e na atual Lei de Diretrizes e Bases da Educação Nacional - LDB 9394/96 (BRSIL, 1996). Com vistas a analisar esta noção basilar da Educação, procuro aplicar os conceitos de Campo e Refração Política com o objetivo de examinar as referidas noções, tomando como fontes a CF/88 e a LDB 9394/96. Ao final do artigo apresento algumas decorrências desta análise.
A responsabilização do Programa de Segurança do Paciente: um novo olhar pela equipe de Enfermagem
Authors: Arantes Rafaela Barboza , Alves Daniele Viana , Consentino Alana Amancio , Celento Denize Duarte
Published: July 2021

A Segurança do Paciente hoje é considerada um dos atributos de qualidade e visa prover um cuidado seguro e efetivo aos usuários dos serviços de saúde, prevê a cultura de segurança do paciente que pode ser entendida como produto de valores, atitudes, percepções e competências coletivas e individuais, que substituem a culpa e a punição pela oportunidade de aprender, algo que vem tentando ser implementado nas instituições. Desta forma, este presente estudo tem como objetivo reavaliar a cultura de responsabilização em ambiente hospitalar visando traçar uma correlação entre “erros” e “riscos”.  Trata-se de uma pesquisa de natureza qualitativa de caráter exploratório realizada com a participação de 08 enfermeiros em dois momentos distintos: inicialmente em um Hospital Geral de Ensino do Interior do Estado do RJ e posteriormente por meio de uma ferramenta de videoconferência. A Coleta de dados foi realizada pela técnica de entrevista em grupo focal. Após a análise da fala dos participantes pode-se concluir que a segurança do paciente ainda é um campo pouco conhecido pelos profissionais desta referida instituição e que mesmo que haja um clima favorável a implementação da cultura de segurança do paciente, os profissionais ainda manifestam o medo de errar, pôde-se perceber também que o Núcleo de Segurança do Paciente ainda não é visto como uma  instância de gestão, portanto sugerimos mediante a explanação dos enfermeiros que o NSP busque a revisão em suas atribuições e atividade de gestão, por fim ressaltamos que o estudo em segurança do paciente não se esgota nesse momento.

Palavras-chaves: Segurança do Paciente; Cultura de Segurança do Paciente; Qualidade da Assistência; Cultura de Responsabilização.
Principais diagnósticos e intervenções de enfermagem no manejo da covid-19 do cuidado primário à alta complexidade
Authors: Silva Jorge Luiz Lima da , Ramos Camille Rabello , Lindolpho Miriam da Costa , Lima Ana Luísa de Oliveira , Abreu Larissa Murta , Oliveira Fernanda Karolinne Rampe
Published: July 2021

Introdução: no final do ano de 2019, tomou-se conhecimento a nova doença viral (covid-19) que se demonstrou um problema de saúde a medida que milhares de indivíduos foram acometidos. Dessa forma, faz-se necessário elencar diagnósticos de enfermagem relacionados ao manejo dos pacientes com a doença.  Materiais e Métodos: trata-se de pesquisa de revisão integrativa de caráter descritivo, que se deu sobre análise da produção científica de enfermagem, baseada em obras secundárias disponibilizadas. Resultados: foram elaborados quadros que apresentam o levantamento dos principais diagnósticos e suas respectivas intervenções em quatro categorias a serem discutidas, sendo: I- diagnósticos levantados para a população brasileira em risco; II- diagnósticos levantados para a população com déficit de conhecimento; III- diagnósticos levantados para o paciente infectado pela covid-19; IV- diagnósticos levantados para a população infectada e com complicações agudas da covid-19. Discussão: os diagnósticos e as intervenções apresentadas representam um subsídio para os problemas encontrados na prática clínica, representando a importância da produção bibliográfica sobre o tema. Considerações finais: identificaram os principais diagnósticos de enfermagem atribuídos aos pacientes de covid-19, destacando para cada diagnóstico elencado suas respectivas intervenções, frisando a necessidade de avaliar particularmente os casos e cenários que podem existir, durante a prática clínica do enfermeiro nos diferentes níveis de atenção.
Palavras-chave: Processo de Enfermagem; Assistência de Enfermagem; Diagnóstico de Enfermagem; Cuidados de Enfermagem; Infecções por Coronavírus.
Síndrome de burnout entre homens de cidade do interior de São Paulo
Authors: Silva Jorge Luiz Lima da , Costa Felipe dos Santos , Bento Luiz Carlos dos Santos , Almeida Giulia Lemos de , Mota Cristina Portela da , Messias Cláudia Maria
Published: July 2021

Objetivo: investigar a suspeição de síndrome de burnout entre o público masculino usuário do Serviço Único de Saúde de Bananal. Método: estudo epidemiológico observacional, descritivo seccional. A amostra totalizou 370 participantes. Utilizou-se questionário autoaplicado, abordando hábitos de vida, medidas antropométricas, e escala Maslach Burnout Inventory (MBI). Foi realizada análise descritiva de regressão logística binária. Resultados: identificou-se a prevalência global de 53%, quando utilizado como critério o desequilíbrio de uma das dimensões da escala. Quando vista a combinação das três dimensões, a prevalência foi de 12,4%; e aqueles que apresentaram despersonificação elevada totalizaram 22,7%. Mantiveram diferença estatística significativa e risco para a síndrome de burnout as variáveis: possuir companheiro (a); ser provedor da família; e etilismo regular. E como fatores de proteção: tabagismo; consumo de drogas; elevado número de refeições ao dia; e a realização de práticas integrativas e complementares. Conclusão: a prevalência de suspeição reflete a vulnerabilidade da população masculina. A baixa frequência do grupo à rede básica de saúde e o perfil sociocultural masculino são fatores colaborativos para baixa adesão a práticas saudáveis.
Palavras-Chave: Esgotamento Profissional; Saúde do Homem; População Rural.
Produção científica sobre saúde do trabalhador de enfermagem em tempos de pandemia: revisão integrativa de literatura
Authors: Silva Jorge Luiz Lima da , Gomes Mariana , Carlos Fabiane  Wendling , Abreu Larissa , Correa Larissa Vieira
Published: July 2021

Introdução: A sociedade enfrenta, atualmente, a disseminação global de um determinado vírus identificado pela primeira vez na província chinesa de Wuhan. Foi declarado estado de pandemia devido à covid-19, causada pelo novo coronavírus. Materiais e métodos: trata-se de uma revisão integrativa da literatura, utilizando-se de fontes bibliográficas secundárias, por meio de levantamento em ambiente virtual. Foi utilizado para a busca nas bases de dados os descritores “saúde do trabalhador”, “covid-19”, “enfermagem”, combinados com operador booleano “and”. Resultados: a seleção foi composta por 16 artigos. No que se refere ao ano de publicação, constatou-se que, em sua totalidade (16), os artigos foram publicados no ano de 2020 mediante à síndrome gripal. Em sua maioria (4), os manuscritos foram publicados nos periódicos LILACS, MEDLINE e SciELO. Discussão: após análise textual e observação dos temas, emergiram 2 categorias levantadas a partir dos resultados encontrados, sendo: aspectos epidemiológicos relacionados à covid-19 e aspectos relacionados às condições de trabalho. Considerações finais: a partir da literatura selecionada pode-se perceber que dada a natureza recente da temática muitos estudos que contemplam o tema ainda estão sendo desenvolvidos e publicados. Espera-se que a produção científica sobre a saúde dos trabalhadores de enfermagem seja fomentada durante a pandemia, pois sua contribuição é tamanha para o desenvolvimento de estratégias de prevenção de doenças e gerenciamento das emoções, revelando-se importantes componentes do enfrentamento dos profissionais a situações delicadas como a pandemia do novo coronavírus.
Palavras-chave: Saúde dos Trabalhadores; Enfermagem; Infecções por Coronavírus; Atenção à Saúde do Trabalhador.
Estimativa da tensão admissível do solo e dimensionamento geométrico de sapatas isoladas e corridas com uso do Excel.
Authors: Brandão Alves do Pinho Bruna , Maria Portugal Alinne Christinna , Brandão de Carvalho Marcelle
Published: July 2021

Sapatas são elementos de fundações rasas, cuja função é transportar as cargas provenientes dos pilares até o solo. Por ser estruturas encobertas, raramente inspecionadas, o dimensionamento dos elementos de fundações deve ser realizado de forma segura e com métodos confiáveis. Um dos ensaios mais difundidos no Brasil, o ensaio com o SPT, fornece resultados que permitem estimar características do solo analisado.  O presente artigo consiste no desenvolvimento de uma planilha elaborada no Microsoft Excel dedicada a otimizar a estimativa da capacidade resistiva do solo e tensão admissível de sapatas isoladas e corridas (cargas cêntricas) e  estabelecer a área da seção transversal mínima, com base no SPT, utilizando-se de métodos empíricos (anteprojeto), semiempíricos e teórico.  Como resultado, temos a estimativa de parâmetros importantes do solo, como ângulo de atrito interno, coesão não drenada (para solos argilosos), peso específico equivalente do solo e obtenção da tensão admissível com agilidade e minimização de erros, além do acompanhamento dos resultados através de gráfico.
Utilização de asfalto-borracha na restauração da pavimentação da rodovia RJ-122
Authors: Vital Richard , Siqueira Clara , Barbosa Carolina , Geraldo Caio
Published: July 2021

O transporte rodoviário tem um papel fundamental para a economia brasileira e, por isso, garantir a qualidade e durabilidade das estruturas civis é um grande desafio para a Engenharia. Devido à escassez de recursos públicos para o desenvolvimento da infraestrutura de transporte, torna-se evidente a necessidade do desenvolvimento de materiais resistentes às condições climáticas adversas e alterações nas condições operacionais. No tocante aos pavimentos, uma solução que vem apresentando bons resultados do ponto de vista ambiental e aumento da durabilidade é o asfalto ecológico, que emprega pneus inservíveis. Nesse sentido, este trabalho discute os principais aspectos relacionados ao emprego do asfalto ecológico na restauração da pavimentação da rodovia fluminense RJ-122.
Inflammatory Biomarkers in the Pathogenesis of Respiratory Dysfunction in People Living with HIV
Authors: Ribes Isabel , Reus Sergio , Asensio Santos , García-Ródenas Mar , León Rafael , Portilla-Tamarit Irene , Giner Livia , Portilla Joaquín
Published: July 2021

Background:

Although the association between HIV infection and airways obstruction
is well known, its etiopathogenesis is not clear.

Objectives:

Our aim was to analyze the association between biomarkers of systemic inflammation
and bacterial translocation and pulmonary function tests in HIV infected patients and compare it between
smokers and non-smokers.

Methods:

Cross-sectional, observational study. Inclusion criteria: people living with HIV with undetectable
plasma viral load. Exclusion criteria: other comorbidities associated with systemic inflammation.
Outcome variables: spirometry and diffusing capacity for carbon monoxide; explanatory
variables: inflammatory biomarkers (interleukin-6, tumor necrosis factor-alpha), bacterial translocation
(soluble CD14 [sCD14] and bacterial 16S rDNA), and variables related to HIV infection.
Associations were tested using the Pearson/Spearman correlation tests, the student t test, and multivariable
linear regression.

Results:

We included 71 patients (54.9% smokers). We did not observe significant differences in
pulmonary function tests according to biomarkers of inflammation or bacterial translocation. In
non-smokers (n=32), sCD14 was negatively correlated with forced expiratory volume in 1 second
(R = -0.35, P = 0.048) and forced vital capacity (R= -0.40, P=0.023). Age, time since HIV diagnosis
and CD4+ nadir were associated with alterations in PFTs. In smokers, the only association observed
was between the pack-years and pulmonary obstruction.

Conclusion:

In non-smokers HIV patients, lung dysfunction can be, at least partially, related to
bacterial translocation (sCD14), CD4+ nadir and time since HIV diagnosis.
Empirical Antimicrobial Therapy and QTc Interval Prolongation in Emergency
Medicine
Authors: Suppa Marianna , Marino Luca
Published: July 2021

Background:

QTc prolongation is common in dangerous clinical conditions, associated
with an increased risk of life-threatening arrhythmia torsades de pointes. The goal of this short communication
is to evaluate the principal causes of risk of QTc prolongation that are observed in an
emergency department and discuss the differences between drug- and non-drug-associated factors.

Methods:

The retrospective analysis was carried out on 130 patients that presented a QTc prolongation
(>480 ms for man and >470 for female, respectively), admitted to the emergency department
of a single Italian hospital. Patients with pace-maker (22) were excluded from this study. For each
patient, a minimum of 3 ECGs (12 leads) were recorded. Attention was paid on electrolytes disturbances
and to the pharmacotherapy, with a particular emphasis to the use of antibiotics.

Results:

Mean age of the patients was 79.6 years (SD=11.3) and females and males were almost
equally present (46.6% F, 53.7% M). The average QTc value was 492.2 ms (493.3 ms F, 492.8 M).
The patients were divided in those with electrolytes disturbances (24.0%), antimicrobial therapy
(35.2%), both antimicrobial therapy and electrolytes disturbances (24.1%), and other causes of
QTc prolongation (16.7%).

Conclusion:

This analysis shows the relevance of the empirical therapy established at the admission,
in particular for infective diseases, as an important risk factor for the prolongation of QTc.
Other factors that can increase the risk are electrolytes alterations, advanced age, cardiovascular diseases,
and drug-drug interaction.
Role of Dysprosium in In2-xDyxO3 to Enhance White Light Emission in OLED
Authors: Verma Om Prakash , Swamy N. Kumar , Mishra Anup Kumar , Meshram Mekh Ram
Published: July 2021

Background:

OLED material is always having much science to explore in them. The
role of rare earth Dy as a dopant material in well studied In2O3 is studied.

Objective:

The candidature of the white light emission from the Organic light emitting diode is
explored in the present work.

Methods:

The doping concentration effect and the corresponding emission is shown in the present
work. It is emphasized that the doping at nearly x = 1 mol% of dysprosium could alter the
transition states and the output of the emission is pure white which is corresponds to the luminescence
peaks. Color purity and co-related color temperature was calculated by CIE technique.

Results:

The spectroscopic parameters are calculated by Judd-Oflet approaches which is suitable
for RE3+ (RE= rare earth) ions.

Conclusion:

The present prepared phosphor is suitable for white light emission and used in display
devices applications.
PERSEPSI STATEMENT TAKERS TERHADAP PENGUNGKAPAN KEBENARAN KONFLIK ACEH
Authors: Rahmah Nailur , Nisa Haiyun , Mirza Mirza , Amna Zaujatul
Published: July 2021

Konflik Aceh menimbulkan korban sebanyak 30.000 jiwa. Konflik ini berakhir damai dengan ditandatanganinya Memorandum of Understanding (MoU) di Helsinki dengan salah satu mandatnya ialah mewujudkan keadilan transisi bagi penyintas konflik yang diwujudkan melalui pengungkapan kebenaran konflik Aceh. Pengungkapan kebenaran dilaksanakan oleh statement takers yang turun langsung ke lapangan untuk menemui penyintas konflik, namun hal ini beresiko bagi statement takers untuk mengalami dampak psikologis. Metode yang digunakan pada penelitian ini adalah kualitatif melalui pendekatan eksploratif. Responden penelitian berjumlah empat orang statement takers yang terlibat dalam pengungkapan kebenaran konflik aceh. Teknik pemilihan sampel menggunakan purposive sampling, serta pengumpulan data melalui wawancara. Hasil penelitian menunjukkan bahwa statement takers mengalami reaksi emosional, terbebani secara moral, serta mengalami dampak fisik dan psikologis. Namun, pengungkapan kebenaran dinilai tepat karena sesuai dengan nilai moral dan budaya masyarakat Aceh. Kesimpulan penelitian ialah pengungkapan kebenaran konflik menjadi tindakan preventif agar konflik tidak terjadi lagi, sehingga pengungkapan kebenaran tetap dilaksanakan demi mewujudkan keadilan transisi dan tetap memerhatikan dampak negatif yang ditimbulkan.
Dampak Sosial Relokasi Pedagang Kaki Lima di Kawasan Wisata Kuliner Kota Tomohon
Authors: Aotama Reynaldo Christian , Klavert Deavy Rosaline Henny
Published: July 2021

Relokasi sebagai upaya penataan dan pengembangan usaha pedagang kaki lima sebagai salah satu sekor informal perlu dilakukan dengan mempertimbangkan beberapa faktor agar dapat terlaksana dengan baik, salah satunya adalah lingkungan sosial pedagang itu sendiri. Tujuan dari penelitian ini adalah untuk mengetahui dampak relokasi terhadap kondisi lingkungan sosial pedagang di Kawasan Wisata Kuliner Kota Tomohon. Jenis penelitian ini adalah penelitian deskriptif kualitatif dengan teknik pengumpulan data yaitu wawancara mendalam, observasi, dan dokumentasi. Hasil dari penelitian ini menunjukkan bahwa dampak dari relokasi terhadap kondisi sosial pedagang secara keseluruhan mengalami peningkatan jika dibandingkan dengan keadaan pada lokasi sebelumnya dilihat dari beberapa aspek seperti kepastian dan jaminan hukum, keamanan dan ketertiban, kenyamanan dan kebersihan, persaingan antar pedagang, serta hubungan sosial antar pedagang. Meskipun demikian ada beberapa kendala yang dihadapi pedagang di lokasi relokasi terutama kurangnya perhatian pemerintah dalam proses peremajaan dan pengembangan lokasi yang berdampak pada semakin berkurangnya pedagang yang berjualan. Penelitian ini mengindikasikan pentingnya pengelolaan lokasi yang berkelanjutan untuk memberikan manfaat yang lebih besar sesuai fungsi dan peruntukannya.
KEDUDUKAN ANAK PEREMPUAN DALAM SISTEM PEWARISAN PADA ADAT ULUN LAMPUNG SAIBATIN DI KECAMATAN PESISIR TENGAH KABUPATEN PESISIR BARAT
Authors: Yusha Bina , Sinaga Risma Margaretha , Widodo Sugeng
Published: July 2021

Ulun (orang) Lampung menganut sistem kekerabatan patrilineal, yakni menarik garis keturunan kebapakan, sangat mementingkan seorang anak laki-laki dalam anggota keluarganya sebagai penerus keturunan. Laki-laki dalam adat ulun Lampung Saibatin memiliki kedudukan yang tinggi dalam prihal penerimaan warisan dibandingkan dengan perempuan. Perempuan hanya sebagai pemelihara harta warisan dan tidak berhak memiliki. Dalam penelitian ini bertujuan untuk memaparkan kedudukan perempuan dan menjelaskan jenis harta warisan yang diperolehnya berdasarkan kedudukannya dalam sistem pewarisan adat ulun Lampung Saibatin. Penelitian ini menggunakan pendekatan kualitatif dengan jenis penelitian etnografi dan menggunakan model interaktif Miles dan Huberman. Data dikumpulkan melalui wawancara mendalam dan observasi. Hasil penelitian menunjukkan kedudukan anak perempuan dalam sistem pewarisan bukan sebagai ahli waris meskipun ia sebagai anak kandung, anak tiri, dan anak angkat serta sebagai waris balu (janda) dalam sebuah keluarga. Kedudukan bukan sebagai ahli waris ini berdampak pada jenis harta yang akan dimilikinya dan keturunannya kelak. Jenis harta materiil dan immaterill di peroleh anak perempuan jika ia memiliki gelar adat dalam masyarakat. Namun, harta yang diperoleh anak perempuan pada umumnya hanya mendapatkan harta berupa materiil saja dengan jenis harta bawaan. Kata Kunci : Kedudukan perempuan, Sistem perwarisan, Adat ulun Lampung SaibatinUlun (people) Lampung adhere to a patrilineal kinship system, which is to draw a fatherly lineage, attach great importance to a boy in a family member as a descendant. Men in the ulun Lampung Saibatin tradition have a higher position in terms of receiving inheritance compared to women. Women are only custodians of inheritance and have no right to own them. This study aims to describe the position of women and to explain the types of inheritance they receive based on their position in the ulun Lampung Saibatin customary inheritance system. This study uses a qualitative approach with ethnographic research type and uses the interactive model of Miles and Huberman. Data were collected through in-depth interviews and observations. The results showed that the position of girls in the inheritance system was not as heirs even though they were biological children, stepchildren, and adopted children as well as inheritors of a balu (widow) in a family. The position of not being an heir has an impact on the types of assets she will have and her future descendants. The type of material and immaterial assets is obtained by a girl if she has a customary title in the community. However, the assets obtained by girls generally only get material assets with the types of assets.Keywords: Position of women, Inheritance system, Traditional of Lampung Saibatin People
CERULOPLASMIN LEVEL AND ITS RELATIONSHIP WITH METABOLIC PARAMETERS IN PATIENTS WITH TYPE 2 DIABETES CONCURRENT WITH NONALCOHOLIC FATTY LIVER DISEASE
Authors: Zemlyanitsyna O. V.
Published: July 2021

A determination of serum ceruloplasmin and its relationship with metabolic parameters in 71 patients with type 2 diabetes mellitus in combination with non-alcoholic fatty liver disease with comorbid autoimmune thyroiditis (group 1, 53 patients) or without (group 2, 18 patients) was concucted. It was revealed an increase of serum ceruloplasmin in 20.8 % of 1st group patients and 27.8 % of 2nd group patients that is regarded as a manifestation of hypoxia of hepatocytes, reduced reactivity of the antioxidant system. A direct correlation of serum ceruloplasmin with indicators of inflammation of the liver tissue, the development of obesity and hypertriglyceridemia in patients of group 1 and adipokine resistin levels in patients 2 groups was found. These regularities require further study.
THYROID HORMONE LEVELS IN OFFSPRING OF MOTHERS WHICH SMOKED DURING PREGNANCY AND HAD MALNUTRITION
Authors: Sokolova S. S. , Sregiyenko L. Yu. , Yakovtsova I. I. , Bondarenko T. V.
Published: July 2021

On the model of the combined effects of passive smoking and reducing of energy intake diet of pregnant female rats was shown that their offspring of both sexes in the postnatal life have disrupted age ensuring body’s thyroid hormone. At the same time a significant number of offspring at an early age have expressed hyperthyroidism at the background of lower body weight. It was expected that this impact is the cause of a high percentage the death of pups of mothers during the first months of life, as had been shown by the authors earlier. It was found that the stress functioning of thyroid system in female offspring of experimental mothers has changing influence on hypothyroid status and leads to obesity at young age.
ROLE OF NUCLEAR FACTOR (NF)-kB PROTEIN IN ATHEROSCLEROSIS AND DIABETES: A POTENTIAL THERAPEUTIC TARGET
Authors: Dolzhenko A. , Richter T. , Sagalovsky S.
Published: July 2021

Cardiovascular diseases and diabetes are the leading cause of morbidity and mortality in all countries. Atherosclerosis, the background for many cardiovascular diseases, is characterized by the accumulation of lipid and fibrotic entities in large arteries and bears many similarities with chronic inflammatory diseases such as diabetes. Common features include extravasation of blood-derived leukocytes, as well as production of cytokines, chemokines and matrix-degrading enzymes. There are also many shared signaling pathways, including activation of the nuclear factor kB (NF-kB) cascade. In the pathology of atherosclerosis and diabetes NF-kB is essential to the cross-talk between cytokines, adhesion molecules and growth factors, leading to atherosclerotic plaque formation, growth and eventual rupture. The intent of this paper is to gather and summarize information on the role of NF-kB in the pathology of atherosclerosis and diabetes. Thus, it is essential to understand the role of this important signaling cascade in atherosclerosis and diabetes, in a quest for more specific therapeutic targets.
THE CLINICAL ASPECTS OF DIABETIC FOOT
Authors: Agaçi F. , Hasho S. , Idrizi M. , Sadedini A. , Tafaj S. , Çelo E.
Published: July 2021

This article presents the results of a survey of 102 patients with diabetes mellitus type 1 and 2 diabetic with diabetic foot syndrome. The mean duration of type 1 diabetes was 13.9 years; type 2 diabetes — 9.9 years. The average level of HbA1c was 8,4_2,2 %. We examined motor  nd sensory functions of these patients, performed Doppler examination of the lower extremities vessels, microbiological examination with sensitivity to antibiotics. 68% of the patients were diagnosed with autonomic neuropathy. Doppler examination revealed occlusion of the arteries in 75% of cases. 49% of patients suffered from dry and wet gangrene. The aim of the treatment was compensation of carbohydrate metabolism, inhibition of the infection process and elimination of ulcers. In 3 patients, conservative therapy was ineffective, and therefore, the amputation was performed. This study like previous one performed in Albania, once again confirmed the importance of the problem of diabetic foot syndrome and the need to address this pathology in everyday medical practice.
AUTOIMMUNE MECHANISMS OF CHRONIC HEART FAILURE PROGRESSION IN ARTERIAL HYPERTENSION AND CHRONIC OBSTRUCTIVE PULMONARY DISEASE WITH CONCOMITANT TYPE 2 DIABETES MELLITU
Authors: Dielievska V. Yu. , Dunaeva I. P.
Published: July 2021

We examined whether autoantibodies against type IV collagen are associated with heart failure progression in arterial hypertension combined with chronic obstructive pulmonary disease with and without type 2 diabetes mellitus. Both patients with chronic heart failure in essential hypertension and chronic obstructive pulmonary disease and patients with concomitant type 2 diabetes mellitus showed higher levels of plasma type IV collagen autoantibodies in comparison to healthy controls. Type IV collagen antibodies correlated with dilation of the left ventricle and reduction of its contractility. Elevation of plasma type IV collagen autoantibodies is associated with progression of chronic heart failure in arterial hypertension combined and chronic obstructive pulmonary with and without type 2 diabetes mellitus.
POSSIBILITIES OF HYPERTENSION PREDICTION IN CHILDREN WITH OBESITY
Authors: Lezhenko G. , Gladun K.
Published: July 2021

The article shows the method of mathematical prediction of hypertension in children with obesity that allows risk groups formation. In adolescents suffering from obesity, the risk of hypertension increases according to the increasing the value of prognostic factors.
ALDEHYDE DEHYDROGENASE ACTIVITY IN THE TISSUE OF INTERNAL ORGANS OF RATS UNDER CONDITIONS OF CHANGING ANDROGEN SATURATION
Authors: Volkova Yu. , Plekhova E. , Sukhova L. , Kozlova O.
Published: July 2021

An increased aldehyde dehydrogenase activity has been found in the liver and heart homogenates of 3-month-old rats under conditions of hypoandrogenia. Testosterone solution administration brings about a decrease in the enzyme activity and puts limitation on the catabolism of carbonyl products in oxidative way of their utilization.
THE ROLE OF DPP-4 INHIBITORS IN DIABETOLOGICAL CARE
Authors: Polozova L. G.
Published: July 2021

Diabetes mellitus type 2 is the most important medical problem in many countries within the world. The features of hypoglycemic drug with high efficiency include the effectivity, safety, usability, ability to prevent progressive deterioration of pancreatic β-cell function under long-term treatment conditions, and positive impact on the outcomes of diabetes. Inhibitors of dipeptidyl peptidase-4 (DPP-4) belong to the class of glucose reducing drugs which has proved the existence of the potential benefit for clinical diabetology in 10 years. The development of incretinomimetics led to changes in national and international recommendations for the therapy of diabetes. Vildagliptin is included to the family of DPP-4 inhibitors which is widely used in many countries among the world for more than 10 years, although it was introduced inside Ukrainian market only in September 2018 (GLIPTAR, production of Kyivmedpreparat). International clinical trials have shown the great potential of the therapy with vildagliptin which can be characterized by the effectivity either the safety, and it may be stipulated by achievement of glycemic control without complications and other side effects. The advantages of Vildagliptin mono-therapeutic strategy compared to the traditional drugs provide the opportunity to be recommended for initiating therapy of 2 type of diabetes. The validated combination of vildagliptin with other glucose-lowering drugs allows to health care specialists to comprehensively build the treatment approach for all stages of the exacerbation of type 2 diabetes therapy.
CLINICAL AND PATHOGENETIC ASPECTS OF THE PURINE METABOLISM STATE IN DIABETES MELLITUS (review of literature and own observations)
Authors: Cherniaieva A. A. , Karachentsev Y. I. , Kravchun N. A. , Tykhonova T. M.
Published: July 2021

In recent years attention has been paid on the state of purine metabolism (PM) in diabetes mellitus (DM) and the possible role of disturbances in the metabolism of uric acid (UA) in the manifestation and progression of this endocrine pathology. Up today it has been proven that the imbalance of UA is a risk factor for the occurrence of such conditions and disorders, which are usually combined with DM, namely: cardiovascular diseases, arterial hypertension, chronic kidney disease and vascular lesions. In addition, hyperuricemia (HUE) is considered as a component of the metabolic syndrome (MS) and the relationship of HUE with insulin resistance is revealed. Despite a significant number of studies on the state of the PM in patients with MS and with type 2 diabetes, there are a number of issues that need to be resolved, and data on the status of the PM in type 1 diabetes are only isolated. Based on a examination of 95 patients with DM, metabolic disorders of UA were detected in 28.42 % of DM patients, including 25.64 % of patients with type 1 DM, 36 % of patients with type 2 DM and 25.81 % of patients with type 2 DM with development of absolute insulin dependence. There are no significant differences in the frequency of imbalance of PM depending on the type of DM and insulin dependence. In patients with DM asymptomatic HUE was observed, so the absence of arthritis is not a criterion for excluding metabolic disorders of UA with diabetes. In patients with type 1 DM metabolic disturbances of UA are associated with complicated forms of the disease, in particular, with the development of diabetic nephropathy and diabetic foot syndrome.
Urinary tract infections and asymptomatic bacteriuria in diabetic patients with pulmonary diseases
Authors: Agaçi F. , Tafaj S. , Xhardo E. , Suraj L.
Published: July 2021

Urinary tract infections and asymptomatic bacteriuria, are more frequent in diabetic patients, especially in those with type 2 diabetes, than in subjects without diabetes. Diabetic people are more risked than persons without diabetes for acute infections of upper urinary tract (pyelonephritis). Some investigators, on the other hand, observed that signs and symptoms of these infections are more severe in diabetics than in non-diabetic people [6–8]. Urinary tract infections can cause severe kidney injuries and, consequently, can lead to chronic kidney disease (chronic renal insufficiency). Concerning pathological mechanisms that explain urinary tract infections and asymptomatic bacteriuria, they are numerous. So, the presence of glucose in urine favours increase and multiplication of miscellaneous pathological microbes .
Metabolic disorders in patients with excessive weights: formation and forecasting
Authors: Misyura K. , Kravchun P. , Dunayeva I. , Kravchun N.
Published: July 2021

According to the results of the complex laboratory-instrumental survey of adult urban population of Kharkiv, a mathematical model has been created that allows estimating the risk of developing metabolic syndrome in patients with excess in terms of anthropometric indices, body composition parameters, carbohydrate and lipid metabolism, clusterin concentration in the blood, and the value of the cardiac index masses of the body of different degrees — representatives of the Ukrainian population. The diagnostic accuracy of the proposed model is quite high: sensitivity — 82.8 %; specificity — 91.45 %; accuracy — 88.07 %; the odds ratio — 40.449. Application of the model in the system of practical health care will improve the risk-stratification of metabolic syndrome, timely conduct therapy to prevent its complications.
Circulating levels of tumor necrosis factor-alpha in type 2 diabetes mellitus patients with non-alcoholic fatty liver disease taking into account the vascular complications
Authors: Tyzhnenko T. , Krasova N. , Gorshunska M. , Leshchenko Z. , Cherniaieva А. , Gladkih A. , Plohotnichenko O. , Jаnsen E. , Роltorak V. , Karachentsev I. , Kravchun N.
Published: July 2021

The relationship between non-alcoholic fatty liver disease (NAFLD) and risk factors for vascular disorders and type 2 diabetes mellitus (T2D) remains the subject of discussion. Therefore, the purpose of our work was to determine the circulatory levels of tumor necrosis factor-alpha (TNF-α) in patients with T2D and to determine the nature of the effect of vascular complications in the presence and absence of NAFLD on this indicator. 146 patients with T2D aged from 28 to 80 years old (68 men / 78 women) were examined, with varying degrees of glycemic control and overweight, without renal insufficiency. 95 surveyed people had NAFLD. 21 practically healthy persons were studied as controls. Compared to controls, patients with T2D at the background of impaired glucose homeostasis were characterized by a marked increase in body mass index (BMI), increased levels of free fatty acids, triglycerides (TG), TNF-α, basal insulin, HOMA-IR indices, and decreased insulin sensitivity. It was found that the average level of TNF-α in patients with T2D (17.88 ± 3.42 pg/ml) was 3-fold higher than in the control group — 5.47 ± 3.44 pg/ml (p < 0.05). Patients with T2D with NAFLD have a greater BMI (35.10 ± 0.77 kg/m2 ) than T2D patients without NAFLD (32.13 ± 0.82 kg/m2, p < 0.001). Stratification of the diabetic population on the base of the presence/absence of NAFLD shown a more pronounced increase in circulating levels of TNF-α in the presence of NAFLD (20.36 ± 4.81 pg/ml vs 10.05 ± 1.62 pg/ml, p < 0.05), which substantiates this parameter utility for further applications as a diagnostic marker. It was found the difference between TNF-α levels in non-NAFLD diabetic patients with different types of vascular complications (p < 0.05 – p < 0.02). There were almost 2-fold higher TNF-α levels in patients with T2D and NAFLD regardless of vascular complication type (p < 0.05). In general, the group of patients without the liver disease had lower levels of TNF-α, but the lowest levels of TNF-α were noted in patients with T2D without the liver or vascular complications (p < 0.05). There was no significant differences in the TNF-α levels in T2D patients with NAFLD regardless macro/microvascular complications, which confirms the leading influence of hepatic insulin resistance and a possible presence of additional factors, that modulate the general level of this proinflammatory cytokine.
Assessment of the condition of pro-/antioxidant systems in the rats heart of different age with hypogonadism
Authors: Volkova Yu. V. , Sukhova L. L.
Published: July 2021

A specific androgen receptor is present in cardiomyocytes. Тhis proves the role of androgens in the work of the heart. Hypoandrogenia can be one of the conditions for changing the intensity of the processes of radical formation and the activity of the antioxidant system in the cells of the heart. Such changes may cause metabolic disorders and may increase the risk of developing and progressing pathological changes in the cardiovascular system. The age characteristics of the oxidative balance in the heart of different ages rats are determined. It is proved, that the influence of hypoandrogenism on the state of pro- / antioxidant systems in the heart of rats is age-dependent. It was found that the condition of androgen deficiency is more reflected on the oxidative balance of the heart of early sexual maturity rats. It has been established that hypoandrogenism is accompanied by modulation of the state of pro- / antioxidant balance in the heart of 3-months-old animals. This leads to the formation of oxidative stress. At the same time, in the heart of 2-months-old rats, under conditions of hypoandrogenism, there are significant changes in the intensity of the processes of free radical oxidation of proteins and lipids, as well as the activity of antioxidant defense enzymes. does not occur due to the fact that the rats in this age have increased basal indicators of redox-balance. It is suggested that testosterone in the heart of pubertal rats is not a key factor in the processes of regulation of the oxidative balance, where as in early sexual maturity age, its properties change towards the antioxidant effect.
Stress and reproductive disorders: modern views on the problem and own research experience
Authors: Seliukova N. Yu. , Gladkova A. I. , Koreneva E. M. , Yaremenko F. G. , Kustova S. P. , Misyura E. V. , Kravchun N. O. , Karachentsev Yu. I.
Published: July 2021

Modern therapy of infertility in men is mainly associated with the use of hormonal and anti-hormonal drugs, but hormonal therapy often leads to a number of negative complications. The list of non-hormonal nature is extremely limited, which is why the study of effective and safe non-hormonal drugs for the treatment of pathospermia and infertility remains an urgent task. The purpose of our work was to evaluate the effectiveness of the new biologically active compound Katiazin — a non-hormonal medicine — for the treatment of pathospermia. The work was performed on sexually mature 6-month rats’ males of the Vistar population. To simulate the pathology of spermatogenesis, animals were stressed for seven days by daily one-hour immobilization on the back with fixation of both pairs of paws. The appointment of Katiazin was carried out from the first day of male exertion in a dose of 0.6 mg/kg body weight daily for 21 days intragastrically. Generative function of males was estimated by the indicators of spermogram and morphometric analysis of the histological structure of the testicles. It was founf that stressing of rats affects all the indicators of spermatogenesis, namely, the amount and mobility of spermatozoa decreases and, conversely, the percentage of pathological cells increases. In animals who taking the Katiazin, all the parameters of spermogram of rats were improved. The analysis of morphometric data suggests that the formation of germ cells at the stage of maturation of sperm from the spermatoid and the stage of spermatogenesis is activated under the influence of Katiazin. The results allow us to recommend Katiazin for the development of a new drug for the treatment of male infertility.
Skin lesions in diabetes mellitus: risk factors for development, clinical manifestations, prevention and treatment
Authors: Tykhonova T. M.
Published: July 2021

The overall prevalence of skin lesions in diabetes mellitus varies from 51.1 to 97 %. More than 30 different dermatoses are described that either precede diabetes or develop against the background of manifest disease. Among a number of dermatoses, diabetic dermopathy, lipoid necrobiosis, disseminated granuloma annulare, bullosis diabeticorum, xanthomatosis, acanthosis nigricans, necrolytic migratory erythema, diabetic scleredema should be noted. Most often, patients with diabetes mellitus have dry skin and hyperkeratosis, which can cause trophic infected ulcers. As a prophylactic agent in such cases, today, SEPTOTON TM BBpharm cream with panthenol and lanolin is proposed
THE CLINICAL AND FUNCTIONAL STATE OF THE THYROID GLAND IN CHILDREN FROM ECOLOGICALLY UNFAVOURABLE AREAS IN THE DYNAMICS OF TREATMENT
Authors: Kech N. R. , Hnateyko O. Z. , Lychkovska O. L.
Published: July 2021

During the period from 2015 to 2017, 359 children between the ages of three and sixteen who originated from and still live in the ecologically unfavourable areas (EUA) of Ivano-Frankivsk region were examined by clinical, laboratory and instrumental means.The aim of the research is to prove the effectiveness of adequate therapy for thyroid ecodependent diseases treatment. The method of the research involves the general clinical and ultrasonic testing of the thyroid gland,as well as the study of its T3 and T4 hormones activity since the pa 3 and T4 hormones activity since the pathology of the thyroid gland is the leading pathology among other ecop T4 thology of the thyroid gland is the leading pathology among other ecopathologies in children from ecologically unfavourable areas. The incidence of almost all analyzed complaints in children from the ecologically unfavour able areas has been higher than in children from ecologically favourable areas. Among the most frequent com plaints from both groups were as follows: emotional lability and excitement (64 % – 72 %),especially in children from the EUAs, headaches (up to 58 %), appetite disorders (49 % – 56 %), fatigability (21 % – 45 %), tachycardia (up to 18 %),and hyperhidrosis (up to 9 %), i.e.complaints common for goitre and unspecific general intoxication. The level of T3 and T4 thyroid hormones revealed that subclinical hypothyroidism is common in areas af 3 and T4 thyroid hormones revealed that subclinical hypothyroidism is common in areas affected by radiation T4 fected by radiation pollution and endemic goitre, whereas subclinical hyperthyroidism is common in chemically polluted areas. The study results demonstrate the effectiveness of the therapy by means of membrane protectors, entero sorbents and iodine preparations, which brought back the indexes of clinical and functional state of the thyroid gland to almost normal in the studied children.