bluuebunny/crossref_metadata_2025 huggingface dataset:
EEG in Education: A Scoping Review of Hardware, Software, and Methodological Aspects
Authors: Orovas Christos , Sapounidis Theodosios , Volioti Christina , Keramopoulos Euclid
Published: December 2024

Education is an activity that involves great cognitive load for learning, understanding, concentrating and other high level cognitive tasks. The use of the electroencephalogram (EEG) and other brain imaging techniques in education has opened the scientific field of neuroeducation. Insights about the brain mechanisms involved in learning and assistance in evaluation and optimization of education methodologies according to student brain responses is the main target of this field. Being a multidisciplinary field, neuroeducation requires expertise in various fields such as education, neuroinformatics, psychology, cognitive science and neuroscience. The need for a comprehensive guide where various important issues are presented and examples of their application in neuroeducation research projects are given is apparent. This paper presents an overview of the current hardware and software options, discusses methodological issues, and gives examples of best practices as found in the recent literature. These were selected applying the PRISMA statement on results returned by searching in PubMed, Scopus and Google Scholar with keywords “EEG and neuroeducation” for projects published on the last six years (2018-2024). Apart from the basic background knowledge, two research questions regarding methodological aspects (experimental settings, hardware and software used) and the subject of research and type of information used from the EEG signals are addressed and discussed.
Could There be Method Behind Kepler's Cosmic Music?
Authors: Redding Paul
Published: December 2024

While Kepler is regarded as a major figure in standard historical accounts of the scientific revolution of early modern Europe, he is typically seen as having one foot in the new scientific culture and one in the old. In some of his work Kepler appears, along with Galileo, to be on a trajectory towards Newton’s celestial mechanics. Besides his advocacy of Copernicus’s heliocentrism, he appeals to physical causes in his explanations of the movements of celestial bodies. But other work expresses a neo-Platonic “metaphysics” or “mysticism”, as most obvious in his self-alignment with the ancient tradition of the “music of the spheres”. Here I problematize this distinction. Kepler’s purported neo-Platonic “metaphysics”, I argue, had been tied to Platonic and neo-Platonic features of the methodology of a tradition of mathematical astronomy that would remain largely untouched by his shift to heliocentrism and that would be essential to his actual scientific practice. Importantly, certain inherited geometric practices—one’s later formalized as “projective geometry”—would carry those “harmonic” structures expressed in the thesis of the music of the spheres.
Derecho a la igualdad y a la no discriminación:¿dónde están las lesbianas?
Authors: Vergara Brambila Nahomi Gabriela
Published: December 2024

La pregunta que acompaña este artículo hace alusión a uno de los textos de Beatriz Gimeno, activista lesbiana, que aborda una de las interrogantes comunes al momento de buscar la presencia lésbica: en la historia, en las luchas de la diversidad sexual, en los textos académicos, en los compilados de arte o incluso en la vida cotidiana donde el respeto a identidades no heterosexuales es una lucha que sigue de pie aún después de: la Declaración Universal de los Derechos Humanos en 1948...
El derecho a la salud de personas migrantes internacionales en tránsito por México
Authors: Rojero Herrera Alejandra
Published: December 2024

El presente trabajo tiene por objetivo responder a dos cuestionamientos: 1) ¿en qué consiste el derecho a la salud?; y 2) ¿cuál es la relación entre migración y salud? Para brindar respuesta estas preguntas se parte de un enfoque de derechos humanos y de la perspectiva de los determinantes sociales de la salud, la cual señala que los factores de riesgo de enfermedad, lesión y muerte no sólo están vinculados a aspectos individuales como la edad, el sexo y el estilo de vida, sino que variables socioeconómicas, culturales y ambientales también contribuyen a explicar el estado de salud de las personas.
Alfabetización Informacional en el uso del conocimiento jurídico mexicano
Authors: Ruiz-Domínguez Arturo Iván , Tarango Javier
Published: December 2024

El presente artículo representa un estudio descriptivo sobre patrones de Alfabetización Informacional (ALFIN) en personas involucradas en ámbitos jurídicos mexicanos, tomando para ello, la aplicación del modelo propuesto por el British & Irish Association of Law Librarians (BIALL) del Reino Unido, mismo que midió cinco dimensiones contempladas del uso del conocimiento jurídico (comprende, realiza, analiza, comunica y se actualiza) convertido en un instrumento tipo encuesta electrónica, mismo que permitió recolectar datos de 141 sujetos de estudio pertenecientes al Tribunal Superior de Justicia en el Distrito Morelos, Chihuahua, México en rangos de puesto varios. Los resultados representan en general bajos índices en el uso del conocimiento jurídico, concluyéndose la necesidad de implementar programas formativos, especialmente en acceso a fuentes de información utilizando medios tecnológicos, observándose la necesidad de generar medios que permitan no sólo el consumo de información, sino la generación de conocimiento.
El Papa pide auxilio a México
Authors: Orozco Víctor
Published: December 2024

El 4 de diciembre de 1848, el Papa Pío IX, desde Gaeta donde se encontraba exiliado, en el reino de Nápoles, Italia, envió una carta al Presidente de la República mexicana en la que clamaba por auxilio frente a los revolucionarios nacionalistas italianos.
25 de noviembre de 1973
Authors: Trevizo Edgar
Published: December 2024

Fragmento:

Ha nevado en Davisville, Missouri. Es domingo y el mundo es temible como una página en blanco...
Carta Amarilla
Authors: Hermosillo Garcia Brenda Sofia
Published: December 2024

Cuento inspirado en el Día de Muertos donde un amante le escribe a otro en un intento de evitar el olvido que la mortalidad supone.
Otras democracias. más allá de la democracia liberal
Authors: Gaytán Martínez Víctor Hugo , Corona Jiménez Josué
Published: December 2024

En este artículo se presentan dos ejemplos sobre practicas democraticas diferentes a la democracia liberal; se reflexiona sobre una democracia con y sin adjetivos y se menciona el riesgo que puede haber y se habla de una democracia sin adjetivs; finalmente se reflexiona sobre aquellas practicas democráticas que van más allá de la democracia liberal.
Mario Bunge y su Filosofía para médicos
Authors: Alarcón Lavín Rafael
Published: December 2024

El propósito del presente texto es ofrecer, en mi calidad de médico y como activista, una breve reﬂexión crítica sobre el libro Filosofía para médicos, del físico y ﬁlósofo Mario Bunge, fallecido a principios de año
Transformaciones en la estructura económica de China entre 1965-2017: un análisis mediante técnicas de insumo-producto
Authors: Pinazo Germán , Borracchia Sabrina
Published: December 2024

Este artículo analiza los cambios en la estructura económica china entre 1965 y 2017. Lo hace utilizando técnicas de insumo-producto y fuentes de información novedosas al respecto; particularmente, la matriz insumo-producto interpaís elaborada por la Comisión Económica para América Latina y el Caribe, sobre datos del Banco de Desarrollo de Asia. Sobre la base de lo anterior, el trabajo muestra tanto los cambios históricos intersectoriales al interior de la economía china, como el rol que ha venido asumiendo dicho país en la provisión global de insumos industriales.
Effect of The Teams Games Tournament Method on Arabic Writing Skills of Student Islamic Junior High School 25 Jakarta
Authors: Setiadi Syamsi , Jannah Eni Nurul , Zulharby Puti , Ilham Andri
Published: December 2024

This research is motivated by the condition of students who have difficulty writing Arabic in Islamic Junior High School students and the need to apply learning methods that are in accordance with the expected competencies. This study aims to determine the influence of the Teams Games Tournament learning method on students' Arabic writing ability. This study is an experimental research with a quasi-experimental design type of experimental group design consisting of 31 students and a control group consisting of 27 students. The sampling technique was carried out by cluster sampling. The data analysis technique used to determine the effect of the independent variable on the bound variable is the t-test. The results showed that t count = 2.52 with a significance of 0.007 lower than 0.05. Thus, it was concluded that there was an influence of the Team Game Tournament method on Arabic writing skills in Islamic Junior High School 25 Jakarta students.
Metabolic Syndrome Prevalence Change Before and After the COVID-19 Epidemic: Using Data from the National Health and Nutrition Examination Survey 2018-2021
Authors: Kim Jung-Hwa , Kim Kyung-Hee , Park Gyu Bin , Lee Won Kee
Published: December 2024

Objectives: In this study, we aim to investigate changes in the prevalence and risk factors of metabolic syndrome before and after the COVID-19 epidemic. Methods: A cross-sectional survey was conducted using data from the 2018-2021 National Health and Nutrition Examination Survey, and 21,159 people were selected for analysis. SPSS version 29.0 program was used to analyze data, and frequency analysis and chi-square test were performed to determine the frequency and ratio of demographic and health behavioral factors before and after the COVID-19 epidemic, and the distribution of metabolic syndrome prevalence. The risk of occurrence by metabolic syndrome prevalence factor was analyzed through logistic regression. Results: As a result of the study, the prevalence of metabolic syndrome increased after the COVID-19 epidemic, and among the five diagnostic criteria, waist circumference, fasting blood sugar, triglycerides, and HDL-cholesterol, excluding blood pressure, increased significantly. In addition, the risk of metabolic syndrome was 1.16 times higher after the COVID-19 epidemic compared to before, and even after controlling for variables such as demographic factors, it was significantly higher at 1.14 times compared to before. Conclusions: Through this study, the prevalence of metabolic syndrome increased during the COVID-19 epidemic due to changes in lifestyle habits, such as decreased activity. If times like the COVID-19 epidemic repeat in the future, we recommend adding and promoting measures that can help manage chronic diseases such as metabolic syndrome when creating national action guidelines to prevent infectious diseases.
Income Changes and Depression Status Following the Impact of Household Income Levels During the COVID-19 Period
Authors: Goo Hyunjin , Park Gyu Bin
Published: December 2024

Objectives: This study investigated income changes and depressive symptoms that occurred following the impact of household income levels during the COVID-19 period using the 2021 Community Health Survey. Methods: A survey was conducted on 185,145 adults aged 19 and older, who responded that the change in household income compared to before the COVID-19 pandemic (January 2020) as “decreased” or “unchanged.” As for the dependent variables, the case was considered depressive if at least one of the following criteria was met: anxiety/depression on EQ-5D, having depression experience, depression using the PHQ-9 score (0-4 points: Not depressed. More than 5 points: Depression), or having suicidal thoughts. The independent variables were defined as quartiles by dividing household income changes during the COVID-19 and annual household income by the number of household members, and the confounding variables were defined as general characteristics, income, health behavior, and status. Results: As the results, the group whose household income decreased during the COVID-19 period was 1.34 times more likely to suffer from depression than the unchanged household income group. In addition, it was confirmed that the possibility of depression increased 1.19 times as the household income level went to the low-income group by 1 quartile compared to the 3rd and 4th quartiles. Conclusions: In conclusion, this study, which consists of a cross-sectional survey, has limitations as it can reveal causal relationships, but overall, depression was higher in people with lower household income, and moreover, the more the income decreased, there were more cases of individuals reporting depressive symptoms. Therefore, in the future, in the event of a new infectious disease outbreak, such as COVID-19, careful national attention is needed from the public health perspective of each household income group, such as supporting essential goods for low-income families and developing mental health programs.
Determinants of Smart Healthcare Utilization: A Focus on Individual Characteristics and Goal-setting Behavior
Authors: Jeong Dahyun , Son Hyelim
Published: December 2024

Objectives: This study aims to investigate the relationship between individual characteristics and health-related behaviors in the context of wearable devices and information and communications technology (ICT) healthcare technology adoption and use. Methods: Using large data from the Smart Healthcare Pilot Project Phase 1, implemented by the Seoul Metropolitan government, we estimate the relationship between individual characteristics and health-related behaviors, namely, physical activity level and sustained usage of ICT. Results: Our empirical analysis reveals variations in physical activity levels and smart healthcare usage sustainability based on participants’ gender, age, obesity status, and goal-setting behavior at program initiation. Notably, we find that setting specific goals is positively associated with higher step counts and sustained engagement in wearable device usage. Conclusions: These findings suggest that future smart healthcare programs should adopt tailored approaches based on participant characteristics and emphasize the importance of goal-setting. Our research contributes to the understanding of factors influencing the effectiveness of wearable devices and ICT healthcare technologies in promoting health-related behaviors.
Regional Factors Affecting Liver Cancer Mortality Using GWR
Authors: Son Jin Hyun , Ryu Wooseok
Published: December 2024

Objectives: This study aimed to identify the regional factors affecting liver cancer mortality using geographically weighted regression (GWR). Methods: Data from 2017 to 2019 were utilized, including health examination statistics and regional medical utilization statistics from the National Health Insurance Corporation, regional infectious disease statistics and community health surveys from the Korea Centers for Disease Control and Prevention, mortality statistics and population census data from Statistics Korea. Spatial data were obtained from the Statistical Geographic Information Service, covering 229 cities, counties, and districts. Statistical analysis was performed using R version 4.3.2, with significant variables identified through ordinary least squares (OLS) analysis, followed by GWR to assess model improvement. Results: The OLS analysis identified percent of population aged 40+, incidence of hepatitis C, high-risk drinking rate, and national health insurance premium as significant factors. Moran’s Index showed a positive spatial autocorrelation (0.373, p<0.001). GWR analysis increased the adjusted R² from 48% to 61% and reduced the AIC from 1,062.21 to 1,038.59, indicating an improvement in the model’s explanatory power and fit. In Jeollanam-do and Jeju-do, the explanatory power was high, and the percent of population aged 40+ had a strong influence in Gangwon-do. The incidence of hepatitis C had a strong influence in the southern coastal regions, the high-risk drinking rate was notably significant in the Yeongnam region, and the national health insurance premium had a strong influence in Busan. Conclusions: As significant factors vary by region, it is considered important to establish health care policies and projects that take into account the characteristics of each region, and through this, we can expect to reduce liver cancer mortality in the region and improve community health levels.
A Method of Applying Mixtures to Optimize Grounding during Installation of Vertical Composite Grounding Devices
Authors: Pavlovich I. A. , Baraishuk S. M. , Murodov M. , Nabiev M.
Published: December 2024

The article considers the method of using mixtures to optimize the electrophysical  parameters of grounding devices in conjunction with vertical composite grounding conductors.  It has been found that fluctuations in soil resistivity caused by changes in weather and climatic conditions can lead to instability of the ground loop resistance. The study shown that without appropriate measures, the resistance of the loop as a result of seasonal changes in soil properties may exceed acceptable values. This is fraught with deviations in the resistance to current spreading of grounding devices beyond the limits of acceptable parameters. To compensate for these fluctuations, a method is proposed to reduce the seasonality factor. Reducing seasonality plays an important role in ensuring the safety of service personnel and farm animals by maintaining the  resistance of the grounding device within the limits of regulatory values. The authors discuss methods for artificially reducing the resistance of the ground loop, including increasing its size and using deep ground electrodes. The results of vertical electrode probing of the soil at the sites of grounding conductors are presented, the effect of humidity on the resistivity of the soil is shown, the influence of soil layering and the presence of moisture-saturated soil layers is considered.  A method is proposed that allows the mixture to be introduced together with a vertical composite grounding device, the design of the coupling, tip and auxiliary device, experimental studies of the proposed designs are carried out and the results of measuring the current spreading resistance  of such a grounding device with both standard and proposed couplings are presented. A comparison was made with a grounding device without the use of mixtures. The measurement results demonstrate that with an increase in the length of the grounding device, its diameter and the volume of the injected mixture, the resistance decreases. It is shown that the proposed solution makes it possible to reduce seasonality by 1.64–2.1 times, depending on the couplings used, and to obtain a grounding conductor with an equivalent diameter dozens of times larger than the diameter of  a composite grounding conductor. The authors propose the use of soil-replacing mixtures to reduce soil resistivity and ensure the stability of the grounding loop throughout the entire service life.  The proposed method of applying mixtures without pre-drilling makes it possible to reduce the cost of constructing grounding devices.
Advances in Engineering Education with an Analysis of the Effect on the Oil and Gas Industry
Authors: Kirkpatrick C. V.
Published: December 2024

This paper presents a comprehensive survey of the current status of engineering education in the United States and analyzes the effect of some of the recent advances on high schools, colleges and universities, and industry. It is noted that many constructive and critical appraisals of engineering education in the United States were made several years prior to Sputnik I and that many of the recommendations incident thereto had already been put into effect at leading colleges and universities. A commonly accepted engineering core curricula is given and the dynamics of its content are reviewed. A follow-up survey is presented on changes in engineering education in academic institutions which have occurred since the ASEE "Report on Evaluation of Engineering Education".

It is concluded that, although college and university curricula are still undergoing significant changes, many constructive advances have been made. In general, the engineering graduate of tomorrow will be a more highly creative and imaginative individual-better equipped, academically, to handle the problems presented by our dynamic technology. Industry will face problems created as a result of this rapid transition to maintain its status as one of the most vigorous and dynamic of industries.

A word of caution is voiced against proceeding too rapidly and too far in a direction which may be leading away from our common educational concepts and philosophy in the United States. Although indirect reference is made to Soviet and European engineering education, no direct comparisons are made; however, references to this subject are given.
Amino Acid-Titanium (III) Complex to Control and Synthesize Different Structures of TiO2 Nanoparticles; Usage as a Photocatalysts for Alcohols Oxidization into Aldehyde
Authors: Shad Nazanin Noroozi , Gholizadeh Mostafa , Absalan Yahya , Kopylov Vladimir Viktorovich , Butsov Leonid Alekseevich
Published: December 2024

Different types of amino acids (Glutamine, Glycine, Alanine) were used to coordinate TiCl3 to find the best precursor for synthesizing TiO2. A full investigation was also carried out to synthesize four different structures of TiO2 nanoparticles (TiO2 (A0.8R0.2), TiO2 (A0.6R0.4), TiO2 (Anatase), and TiO2 (Rutile)). Oxidation of alcohol derivatives to their corresponding aldehyde was assessed using the developed nanoparticles as the photocatalyst, under UV light to find the best structure of TiO2. Different physical-chemical analyses were applied to characterize the samples. The results showed that the titanium oxide nanoparticle can be synthesized by the use of glycine at the lowest temperature; thus it was chosen as a precursor to synthesis four different types of TiO2. All the synthesized TiO2 were applied to oxidize benzyl alcohols into benzaldehyde. TiO2 (A0.6R0.4) led to the best efficiency (87%). Hence, it was employed to oxidize benzyl alcohol, 4-cholorobenzyl alcohol, 4-nitrobenzyl alcohol and 4-methoxybenzyl alcohol to their corresponding aldehyde which resulted in the efficiencies of 74, 92, 87, and 65%, respectively.
Fluorescence Imaging-Assisted Thoracoscopic Anatomical Lesion Resection in Treating Congenital Lung Malformation
Authors: He Taozhen , Sun Xiaoyan , Che Guowei , Luo Dengke , Yuan Miao , Yang Gang , Cheng Kaisheng , Xu Chang
Published: December 2024

Identification of lesion demarcation during thoracoscopic anatomical lesion resection is fundamental for treating children with congenital lung malformation. Existing lesion demarcations do not always meet the needs of clinical practice. This study aimed to explore the safety and efficacy of near-infraredfluorescence imaging with nebulized inhalation of indocyanine green for thoracoscopic anatomical lesion resection in children with congenital lung malformation. Under the fluorescence scope, the area of uniform green fluorescence was produced when indocyanine green was distributed into normal lung tissue, and lesions showed little or no green fluorescence, thus delineating a clear fluorescent lesion demarcation. Under the guidance of fluorescent demarcation, all the patients except one case of extralobar sequestration underwent thoracoscopic anatomical lesion resection successfully.
Ante-mortem Diagnosis of Unilateral Pulmonary Vein Stenosis in a Cat: A Case Report
Authors: Aoki Takuma , Miyamoto Takashi , Kizaki Kota , Ueshima Asuka , Iwasaki Kentaro , Kusaka Takuya , Terui Haruko
Published: December 2024

Background: Pulmonary hypertension (PH) in cats may be challenging to detect. Pulmonary venous stenosis (PVS) is rare in cats and can lead to PH. The only reported case of PVS received a postmortem diagnosis. Imaging during the cat's lifetime established the diagnosis in this case.
Case presentation: A 2-year-old Norwegian Forest cat was diagnosed with pulmonary oedema and PH secondary to cor triatriatum sinister(CTS) and showed improved breathing following twice subcutaneous furosemide treatment, 1 and 2 mg/kg, during an overnight stay at the referral veterinary hospital. Sildenafil alone (0.69 mg/kg, PO, BID) was prescribed post-discharge to address PH without diuretics. Following discharge from the referral veterinary hospital, collapse and pre-syncope were suspected to be due to PH. Consequently, sildenafil was titrated weekly, starting at 1.09 mg/kg BID and then increasing to 1.63 mg/kg BID. Pre-syncope and collapse resolved, and pulmonary opacities reduced considerably, although concerns remained that increased pulmonary blood flow to suspected CTS from sildenafil might worsen cardiogenic pulmonary oedema. The patient was also treated with rivaroxaban (2.5 mg/head, SID), considering the increased risk of thrombus formation due to blood flow stasis and endothelial damage. Thirty-eight days later, the cat presented to our hospital for examination. On echocardiography, the continuous mosaic blood flow (maximum and minimum velocity, 3.14 m/s; estimated pressure gradient, 39.4 mmHg) was observed in two enlarged pulmonary veins. Pulmonary artery enlargement (main pulmonary artery to thoracic aorta ratio: 1.90), pulmonary vein stenosis (PVS), and diffuse bilateral ground-glass lung opacities were observed using computed tomography. PH with unilateral PVS involving two out of the three right pulmonary veins, specifically the right cranial and right middle pulmonary veins, along with pulmonary parenchymal disease, was diagnosed. The cat was further treated with furosemide (1 mg/kg, BID, PO) with no clinical signs but succumbed to acute dyspnoea 51 days after the first visit.
Conclusions: Unilateral PVS should be considered in young cats with a localised alveolar pattern, as the prognosis may be poor. Severe PH with PVS may coexist with lung disease. If sildenafil is used, it should be started at a low dose and monitored closely.
Development of a Nomogram for Predicting Malignancy in BI-RADS 4 Breast Lesions Using Contrast-Enhanced Ultrasound and Shear Wave Elastography Parameters
Authors: Ren Tiantian , Gao Zhenzhen , Yang Lufeng , Cheng Weibo , Luo Xiao
Published: December 2024

Background
This study aimed to construct a Least Absolute Shrinkage and Selection Operator (LASSO) logistic regression (LR) model using Shear Wave Elastography (SWE) and Contrast-Enhanced Ultrasound (CEUS) quantitative imaging features to accurately assess the malignant probability of Breast Imaging Reporting and Data System (BI-RADS) 4 breast lesions (BLs).
Methods
Female patients (n = 111) with BI-RADS 4 BLs detected via routine ultrasound at Ma'anshan People's Hospital underwent SWE, CEUS, and histopathological examinations. Histopathological results served as the benchmark. LASSO LR analysis with 10-fold cross-validation identified significant imaging features for malignancy prediction. A predictive nomogram was developed and validated with bootstrap sampling. Performance was assessed using calibration curves, Receiver Operating Characteristic (ROC) analysis, and decision curve analysis (DCA).
Results
Histopathological analysis revealed 35 malignant and 76 benign BLs. Significant features included peak intensity (PI) from CEUS (odds ratio [OR] = 5.788, p < 0.05), the area under the curve (AUC) from CEUS (OR = 6.920, p < 0.05), and Maximum Young’s Modulus (SWE_Max) from SWE (OR = 10.802, p < 0.05). The nomogram showed an AUC of 0.875 (95% CI: 0.805–0.945), sensitivity of 0.886, and specificity of 0.684, with good calibration and clinical utility.
Conclusion
The nomogram outperformed traditional BI-RADS methods, providing excellent predictive performance for distinguishing malignant from benign BI-RADS 4 BLs and reducing unnecessary biopsies.
Exploration of treatment burden through examination of workload and patient capacity during transition onto kidney replacement therapy: a systematic review of qualitative research
Authors: Jones Catrin , Cairns Ross , Walker Heather , Welsh Silje , Edgar Benjamin , Stevenson Karen , Jani Bhautesh D. , Mark Patrick B. , Kingsmore David , Gallacher Katie I.
Published: December 2024

Background:
Patients with advanced chronic kidney disease requiring initiation of Kidney Replacement Therapy (KRT) are frequently asked to enact complex management plans. Treatment burden has been defined as the effect of healthcare workload and the capacity a person has to manage this workload has on wellbeing. The aim of this review is to examine the experience of healthcare workload and the factors that affect capacity to meet that workload for people transitioning onto KRT for the first time, using a framework synthesis of published literature informed by Normalisation Process Theory (NPT) and Theory of Patient Capacity (TPC).
Methods: Medline, Scopus and CINAHL were systematically searched with manual citation and reference searching. Studies were included if meeting the criteria of adults aged 18 or over transitioning for the first time onto any modality of KRT (haemodialysis, peritoneal dialysis or kidney transplantation), using qualitative methodologies to describe any aspect of experiences of healthcare workload or any factors that affect capacity to manage workload were included. Abstracts and full papers were independently screened by two reviewers and data extraction and quality appraisal were also independently conducted by two reviewers. Qualitative data were analysed using framework synthesis informed by NPT and TPC.
Results: 24,380 studies were screened, 406 full texts were reviewed and 18 studies were included. There were four broad categories of workload described: making sense of KRT, working out what to do and how to do it, meeting the challenges of KRT, and reflecting on work done. Patient capacity influenced the experience of all types of workload and the treatment burden generated by the work.
Conclusion: Transitioning onto KRT is a period of very high healthcare workload and potentially high treatment burden. The relationship between healthcare workload and capacity to handle workload is complex, multifactorial and changes over time. By better understanding workload, capacity and burden during transition we can develop better ways of measuring these important aspects of care and develop interventions to reduce treatment burden in those transitioning onto KRT.
RvD1 Combined with Exercise Promotes Mitophagy and Reduces Neuronal Apoptosis in Mice After Intracerebral Hemorrhage via the BDNF/TrkB/PI3K/AKT Pathway
Authors: Lv Xiaoyu , Dandan Li , Tianzhao Ouyang , Ziyou Zhang , Zhuang Li , Mingrui Liu , Yusong He , Yangyang Zhong , Yanjiao Li , Chun Shi , Siqi Wang , Tong Li , Bensi Zhang
Published: December 2024

Resolvin D1 (RvD1) is an endogenous anti-inflammatory mediator that can modulate the inflammatory response and promote inflammation resolution. RvD1 has been shown to exert neuroprotective effects in various central nervous system contexts; however, its role in the pathophysiological processes of Intracerebral hemorrhage (ICH) and the potential protective mechanisms when combined with exercise rehabilitation training remain unclear. In this study, we aimed to investigate whether RvD1 combined with exercise rehabilitation training could protect against neurological deficits in ICH mice by activating the BDNF/TrkB/PI3K/AKT signaling pathway, improve cognitive function, reduce neuronal apoptosis and inflammatory response, and explore its relationship with mitochondrial autophagy. A mouse model of ICH was established using collagenase, and treatment with RvD1 combined with three weeks of exercise rehabilitation significantly improved neurological deficits, muscle strength, learning and memory in the cerebral hemorrhage mice while reducing anxiety-like behavior. RvD1 combined with exercise rehabilitation training can up-regulate anti-inflammatory factors, inhibit inflammatory state and activate BDNF/TrkB/PI3K/ akt related pathway.TUNEL staining confirmed a decrease in residual apoptotic neurons, while transmission electron microscopy showed an increase in mitochondrial autophagosomes with combined treatment. Mendelian randomization and molecular docking further confirmed the association of RvD1 with targets related to mitophagy and inflammatory factors, thereby clarifying the mechanism of RvD1 involvement.In summary, RvD1 combined with exercise rehabilitation can activate the BDNF/TrkB/PI3K/AKT signaling pathway, effectively reduce neuronal apoptosis and inflammatory responses following ICH in mice, and participate in mitochondrial autophagy-related states. This comprehensive therapeutic strategy promotes neurological recovery and provides insights for the clinical management of this condition.
Crystal structure analysis of four 2-pyridineformamide thiosemicarbazone derivatives using non-spherical atomic form factors
Authors: Shakya Bhushan , Mahiya Kuldeep , Shrestha Ramina Maharjan , Oli Hari Bhakta , Yadav Paras Nath
Published: December 2024

The crystal structures of four 2-pyridineformamide thiosemicarbazone derivatives viz, (Z,Z’)-4-methyl-N'-(morpholine-4-carbonothioyl)picolinohydrazonamide (1), (Z,Z’)-4-methyl-N'-(thiomorpholine-4-carbonothioyl) picolinohydrazonamide (2) and (Z,Z’)-6-methyl-N'-(thiomorpholine-4-carbonothioyl)picolinohydrazonamide (3) and (Z,Z’)-N'-(azepane-1-carbonothioyl)-4-methylpicolinohydrazonamide (4) has been determined by single crystal X-ray diffraction analysis. Combined quantum mechanical methods (ORCA) and computation of non-spherical scattering form factors (NoSpherA2) were used for the refinement with anisotropic hydrogen atoms. The results of using independent atom model (IAM) and Hirshfield atom refinement (HAR) method based R2SCAN/ def2-TZVP functional were compared. All compounds show an improvement in the model after HAR refinement compared to independent atom model (IAM). There is a significant decrease in the residual factors with the use of anisotropic hydrogen refinement. HAR refinement provides a clearer understanding of electron delocalization, lone pairs, and the accumulation and depletion of electron density. The information obtained came from standard resolution single crystal X-ray diffraction data, indicating that high-quality structural analysis can now be performed without the need for neutron or synchrotron facilities.
One sentence essence:
Hirshfield atom refinement provides a clearer understanding of electron delocalization, lone pairs, and the accumulation and depletion of electron density.
Cerebral Venous Thrombosis Presenting as Lower Limb Action Myoclonus: A Case Report
Authors: Osayan Andre Anthony A. , Autentico Alicia Rose T. , Villamor Reynaldo Benedict V. , Saranza Gerard Raimon M.
Published: December 2024

Introduction:
Cerebral venous thrombosis is a rare stroke caused by occlusion of venous sinuses. Most cases usually present with headaches, seizures, or focal deficits, but rarely as movement disorders.
Case Report:
Herein we describe a 57-year-old female who presented with action myoclonus in the right lower extremity. Venous thrombosis involving the straight and inferior superior sagittal sinuses was noted on CT angiography. She was then treated with Apixaban and Levetiracetam, with good control of the myoclonic jerks. However, she later developed an action myoclonus and weakness of the left leg due to venous infarction. Cerebral angiography showed clearing of thrombosis in the previously affected sinuses. Workup for prothrombotic conditions predisposing to venous thrombosis was unremarkable. Anticoagulation with Warfarin and a higher dose of Levetiracetam eventually afforded a gradual improvement of the weakness and complete resolution of her myoclonus.
Conclusion
Although rare, cerebral venous sinus thrombosis should also be considered as an acquired cause of action myoclonus.
The Impact of Family Care on Sleep Quality in Perimenopausal Women: Mediating Roles of Anxiety and Depression
Authors: Liang Nana , Zhao Juan , Ren JiShun , Shi Xinyi , Zheng Haixia
Published: December 2024

Background
Family systems theory posits that the family serves as the most intimate social support network, offering patients practical care, companionship, and emotional communication. Effective family functioning can significantly enhance patients' sleep quality. This study aimed to investigate the effects of family care on sleep quality and its mechanism of action in perimenopausal women in Gansu Province, and to provide theoretical support for alleviating anxiety and depression levels and improving sleep quality in perimenopausal women.
Methods
Perimenopausal women (n = 860) in Gansu Province were surveyed using the Self-Rating Scale of Sleep, Self-Rating Anxiety Scale, Self-Rating Depression Scale, and Family Adaptation Partnership Growth Affection Resolve.
Results
The sleep quality, anxiety, and depression scores of perimenopausal women in Gansu Province were 25.33 ± 5.00, 40.74 ± 10.89, and 40.77 ± 10.03, respectively, and the family care score was 6.64 ± 2.36. Family care was negatively correlated with sleep quality, anxiety, and depression scores; anxiety was positively correlated with depression and sleep quality scores, and depression was positively correlated with sleep quality scores. Anxiety and depression in perimenopausal women partially mediated family care and sleep quality, with mediating effects accounting for 15.74% and 60.69% of the total effect, respectively.
Conclusion
Family care has a direct predictive effect on sleep quality in perimenopausal women, and anxiety and depression mediate the relationship between family care and sleep quality. Lowering anxiety and depression levels in perimenopausal women is an effective way to improve sleep quality.
UBE decompression combined with percutaneous pedicle screw internal fixation for thoracolumbar burst fracture with secondary spinal stenosis: a technical note
Authors: Bai Guangchao , Qiu Xiaowen , Wei Guojun , Jing Xiaowei , Hu Qingfeng
Published: December 2024

Objective:The purpose of this study was to present the surgical technique of UBE decompression combined with percutaneous pedicle screws for the treatment of thoracolumbar burst fractures with secondary spinal stenosis.
Background: Thoracolumbar burst fracture is a common traumatic disease in spinal surgery, the incidence of Atype fracture is the highest in the AO classification of thoracolumbar burst fracture, accounting for about 70% of the fracture, which is most common in the A1 and A3 fractures [1], and the fracture of the A3 fracture often occurs in the fracture block to the intra-vertebral canal displacement, resulting in secondary stenosis. The traditional approach is posterior open surgery pedicle screws combined with direct visualization for decompression, which requires extensive stripping of paravertebral muscles and resection of more bone, and is more traumatic [2], which is not in line with the current development concept of minimally invasive spine. The UBE technique in spinal endoscopy is currently a hot spot in the development of minimally invasive spine [3], and we attempted to utilize UBE decompression combined with percutaneous pedicle screws to treat thoracolumbar burst fracture with spinal stenosis, which provides a new option for the surgical treatment of thoracolumbar burst fracture with spinal stenosis.
Methods: We included five patients with thoracolumbar burst fractures with secondary spinal stenosis admitted to our hospital between January 2023 and January 2024, who were treated with sub-UBE decompression combined with percutaneous pedicle screw internal fixation by our team. The degree of correction of spinal deformity was assessed using the sagittal Cobb angle and the percentage of height of the anterior margin of the vertebral body, the rate of canal encroachment was used to assess the decompression of the spinal canal, and the recovery of the patients' ability to live was assessed using the VAS and JOA scales.
Results：the results showed that the average operative length of the patients was 154.2mins, and the average intraoperative bleeding was 90ml; the sagittal Cobb angle averaged 22.23° preoperatively, and 6.10° at 3 days postoperatively; the anterior vertebral body height ratio averaged 36.77% preoperatively, and 91.16% at 3 days postoperatively; and the residual spinal canal volume averaged 52.01% preoperatively, and 91.58% at 3 days postoperatively; VAS score averaged 7 preoperatively and 2 at 3 days postoperatively; JOA score averaged 8.4 preoperatively and 22.4 at 3 days postoperatively.
Conclusions：UBE decompression combined with percutaneous pedicle screws is effective in the treatment of thoracolumbar burst fractures with secondary spinal stenosis and is a safe, minimally invasive surgical option for this patient population.
Factors Associated with Prevalence of Malaria among Children-under-5-Years Following Mass Net Campaign and Indoor Residual Spraying in Amolatar District, Northern Uganda: Cross-Sectional Study
Authors: Orech Sam , Opollo Marc Sam , Auma Irene , Ocen Francis , Akello Anne Ruth
Published: December 2024

Background: Globally, 3.3 billion people are at risks of contracting malaria, and the disease still endemic in 91 countries. Despite the scale up of interventions geared towards controls and eliminations of malaria, the number of malaria cases that progress to severe causing malaria-related deaths remains high. WHO identified mass LLINs distribution and IRS as effective measures for malaria preventions and control. In 2021, malaria caused an estimated 247 million clinical episodes and 619,000 deaths mostly vulnerable children in sub-Saharan Africa.
Objective: To determine the prevalence of malaria and associated factors among children under 5 years following mass net (LLINs) campaign and indoor residual spraying in Amolatar district, Northern Uganda.
Methods: A community-based, cross-sectional research design used. Quantitative survey for data collection employed. We collected blood sample from children under 5 years to detect the prevalence of malaria using plasmodium falciparum malaria rapid diagnostic test (PF.mRDT). Bivariate analysis and multivariate logistic regression analysis at 95% CI, p-value of 0.05 for significant variables were performed to identify the factors associated with the prevalence of malaria among children under 5 years.
Results: Overall, 44.1% (105/238) of children tested positive of malaria. The mean age the caretakers were 24 years, SD 9.4. More than half of caretakers had attained primary level of education 50% (119/238). Children living with married caretakers had 3.2 increased odds of testing positive for malaria (AOR 3.2, 95%CI: 1.395-7.378, P<0.006). Having 2 children in the HH had a significant association of testing positive for malaria (AOR 0.4, 95%CI: 0.219-0.869, P<0.018]). However living in the HH ≥6Km from water body (AOR 0.3, 95%CI: 0.024-3.532, P<0.334) wasn’t significantly associated of testing positive for malaria.
Conclusion: Children who lived with the married caretakers, having 2 children in the HH, and not sleeping under the LLINs had significant association of testing positive for malaria. While living in a HH ≥6Km from stagnated water bodies had reduced odds of testing malaria positive. We recommend strengthening awareness campaigns on the importance of consistent use of LLINs while targeting caretakers especially married households (HHs), where LLINs usage is low and community engagement strategies that focus on behavioral change to increase LLINs adherence.
Application Value of Central Venous-arterial Carbon Dioxide Partial Pressure Difference in Postoperative Cognitive Dysfunction in Patients with Acute Aortic Dissection
Authors: Wang Lei , Wang Zhen Hong , Zhu Duan QI , Xie Xin Yi , Wang Xiao Liang , Chen Xin
Published: December 2024

Objective
This study aims to investigate the clinical application value of the central venous-arterial carbon dioxide partial pressure difference (Pv-aCO2) in postoperative cognitive dysfunction(POCD) in patients with acute aortic dissection.
Methods
A retrospective analysis was conducted on the general data of 236 patients. Blood gas samples were collected from the arterial and venous lines at various time points during the surgery, including before and after the initiation of cardiopulmonary bypass (CPB), immediately after CPB initiation, before and after deep hypothermic circulatory arrest, 30 minutes after rewarming, and 5 minutes before weaning from CPB. The partial PV-aCO2 was calculated. Based on the average PV-aCO2 value, patients were divided into an observation group (PV-aCO2 > 6 mmHg, n = 112) and a control group (PV-aCO2 < 6 mmHg, n = 124). The perioperative data and Mini-Mental State Examination (MMSE) scores were compared between the two groups to assess the incidence and severity of POCD. Additionally, the expression levels of peripheral serum S100β in the two groups were compared 6 hours postoperatively.
Results
The incidence of POCD was higher in the observation group compared to the control group, while MMSE scores and serum S100β levels were lower in the observation group. Additionally, the observation group patients with POCD had lower MMSE scores and serum S100β levels compared to the control group patients. In addition, logistic regression analysis revealed that advanced age, serum S100β levels, female gender, CPB time, unilateral brain perfusion time, hyperlipidemia, diabetes, and smoking history were all independent risk factors for postoperative POCD (all P < 0.05).
Conclusion
Pv-aCO2 can effectively reflect the intraoperative cerebral metabolic level in patients with acute aortic dissection and can serve as an intraoperative warning indicator for cognitive dysfunction. Its clinical recommendation for use is warranted.
Association of triglyceride-glucose-related obesity indices with sarcopenia among U.S. adults: A cross-sectional study from the National Health and Nutrition Examination Survey
Authors: Zhao Runtao , Wang Fan , Ji Xinqiang
Published: December 2024

Background Sarcopenia, identified by a decline in muscle mass and function, poses a significant health challenge, particularly among elderly individuals. Its association with cardiovascular diseases and metabolic disorders necessitates the exploration of early diagnostic markers. The triglyceride-glucose (TyG) index, a novel indicator of insulin resistance, has shown promise in predicting metabolic diseases, but its relationship with sarcopenia remains unclear.
Methods This cross-sectional study analysed data from the National Health and Nutrition Examination Survey (NHANES) to evaluate the associations between the TyG index and obesity-related parameters (TyG-BMI, TyG-WC, and TyG-WHtR) with sarcopenia. A total of 7,636 participants were included after applying strict exclusion criteria. Logistic regression models adjusted for potential confounders were used to assess the relationship.
Results This study revealed a significant positive association between TyG-WHtR and sarcopenia, with the highest odds observed in the fourth quartile (OR: 11.2, 95% CI: 5.87--21.50; P < 0.001). Compared with the other indices, the TyG-WHtR also demonstrated superior diagnostic efficacy for sarcopenia, with an AUC of 0.79. No significant associations were found for TyG, TyG-BMI, or TyG-WC after full covariate adjustment.
Conclusions The TyG-WHtR, which integrates lipid and anthropometric measures, has emerged as a potent predictor of sarcopenia, outperforming the TyG index alone. This study underscores the importance of considering metabolic and body composition factors in sarcopenia risk assessment, offering a potential avenue for early intervention strategies.