bluuebunny/crossref_metadata_2025 huggingface dataset:
RANCANGAN SISTEM INFORMASI UKM STMIK KOMPUTAMA MAJENANG BERBASIS WEB
Authors: Diky Setiawan  , Miftahul Khoeri Amarulloh , Fajar Syafani Henky , Ristianingsih  , Bambang Sumantri R Bagus
Published: June 2021

Student activity unit (UKM) STMIK KOMPUTAMA MAJENANG is a student organization outside the classroom that is engaged in various fields, such as Wanacetta, Racana Pramuka, Sports, Web Programing, etc. Information dissemination to UKM itself is not yet fully effective, it needs information media to publish information related to UKM. Among other things, to find out information related to the field of UKM, participate in UKM, and can also participate in managing UKM management. Therefore, this system was created to help students and lecturers to get information about UKM and facilitate data management that can be accessed via a Web browser. This information system was created using the Waterfall method, Boostrap Framework, Html, Css, PHP programming language and MYSQL database. This system is still in the form of a design or prototype that has not been fully completed, it is still in the development process. So that there is still a need for further processes in completing the Prototype of this System both from Design, Content of the website, Testing, and also maintenance.
Kompetensi Keamanan Jaringan Sesuai Kebutuhan Industri ISP (Internet Service Provider)
Authors: Dina Merlinda Izzah
Published: June 2021

Kesesuaian antara kompetensi yang dimiliki oleh seorang lulusan dengan kebutuhan dunia kerja sangat penting agar dapat saling bersinergi dalam menjalankan keberlangsungan di dalam suatu lingkungan kerja. Hal ini perlu untuk dikaji dan diketahui ketercapaiannya sebagai bahan evaluasi baik dari pihak sekolah agar lebih relevan dengan kebutuhan dunia kerja.

Penelitian ini bertujuan untuk mengetahui kompetensi Keamanan Jaringan yang dibutuhkan oleh industri ISP dari lulusan SMK kompetensi keahlian Teknologi Komputer dan Jaringan (TKJ). Subjek penelitian ini adalah guru mata pelajaran SMK kompetensi keahlian TKJ. Adapun objek penelitiannya adalah kompetensi Keamanan Jaringan lulusan SMK kompetensi keahlian TKJ yang dibutuhkan oleh industri ISP.

Instrumen dalam penelitian ini menggunakan angket yang terdiri dari kompetensi pengetahuan, keterampilkan, sikap, dan moral. Kompetensi pengetahuan mengacu dari Kompetensi Dasar (KD) pada Kompetensi Keahlian (KI)-3, dan keterampilan mengacu dari KD pada KI-4. Kurikulum yang diimplementasikan pada penelitian ini adalah Kurikulum 2013 (K-13) sebelum revisi dan K-13 Revisi 2017. Hasil penelitian menunjukkan bahwa terdapat beberapa kompetensi Keamanan Jaringan yang dibutuhkan oleh industri ISP dari lulusan SMK kompetensi keahlian TKJ yang terdapat pada KD mata pelajaran.
Implementasi Data Mining untuk mengelompokkan Pasien Rawat Jalan dan Rawat Inap Asuransi Kesehatan
Authors: Ratih  , Mahardika Fajar
Published: June 2021

Patient Visits Outpatient and inpatient insurance at Class C Hospitals is increasing from year to year. Increased visits to insurance patients will have an impact on the inpatient and outpatient health services provided. From the increase in patient visits, the data owned by the hospital is increasingly abundant. The data can be used to explore knowledge, find certain patterns.

To explore knowledge about Inpatient and Outpatient Insurance patients, data mining clustering techniques are used with the Self Organizing Map (SOM) algorithm using R Studio tools. Clustering technique with the implementation of the Self Organizing Map (SOM) algorithm is a technique for grouping data based on certain characteristics which are then mapped into areas that resemble map shapes. The CRISP-DM method is used in this study to perform the stages of the data mining process.

The results obtained from the implementation of clustering with the Self Organizing Map (SOM) algorithm are obtained 2 clusters representing dense areas and non-congested areas. Dense areas are represented by Internal Medicine Clinic, Surgery Clinic, Eye Clinic, Hemodialysis, Melati Room, Orchid Room, Bougenville Room, Flamboyan Room. Non-crowded areas are represented by General Clinics, Dental Clinics, Obstetrics and Gynecology Clinics, Children's Clinics, Mawar Room and Soka Room
Evaluasi Service Operation dan Pembuatan Dokumen Service Strategy Menggunakan Framwork ITIL Versi 3 (Studi Kasus : BPPW Jabar)
Authors: Zulkifli Ridwan
Published: June 2021

BPPW JABAR (Balai Prasarana Permukiman Wilayah Jawa Barat) under the Ministry of Public Works and Public Housing Directorate General Cipta Karya, is a representative of the Central Government to support the Coordination function with the Regional Government,

In the BPPW JABAR organizational structure, there is an Individual Consultant who is placed specifically to deal with obstacles experienced by the organization in the use of IT services, but in its application, there has never been an evaluation for any process of repairing the constraints experienced and documentation for the process of repairing IT service constraints, resulting in every obstacle never experienced repeated with the same case. That is because the number of people who handle IT problems is only 1 person and there is no IT work structure so that work is carried out based on continuous orders, if it continues to occur it will result in obstruction of existing business processes and processes, due to problem handling IT services are not completed quickly and precisely because of the limitations of people and lack of documentation for any problems that have been experienced and resolved. Not just repairing IT service constraints. In the BPPW JABAR organization the dependence on centralized data and secure data storage becomes a high need because every existing data is important and confidential data because it is related to planning data and the implementation of development in the field of Cipta Karya, so the need for an IT service for data storage centralized and can be shared specifically for the work environment of the BPPW JABAR organization and people who have access to the data.

The steps taken are evaluating IT services in service operations to assess the level of readiness of the IT problem improvement process experienced by the organization while using IT services and to conduct a GAP analysis between the existing conditions of IT service improvement with the level of maturity expected by the organization in the process of improving IT services and design service strategy for related centralized data and can be shared.
PERANCANGAN SISTEM INFORMASI PENJUALAN LIMBAH HASIL PABRIK GARMENT BUSANA MUSLIM BERBASIS WEB (Studi Kasus : PT. Shafco Multi Trading)
Authors: Andryadi Aan Ansen , Muniroh Nur
Published: June 2021

Berdasarkan pada undang-undang Nomor 32 Tahun 2009 tentang Perlindungan dan Pengelolaan Lingkungan Hidup, Perusahaan diwajibkan untuk menjaga lingkungan  disekitarnya. Untuk itu limbah hasil produksi yang dihasilkan harus diuji terlebih dahulu sebelum dibuang ke alam dan harus dipastikan aman serta tidak berbahaya bagi lingkungan. Berdasarkan undang-undang tersebut, PT. Shafco Multi Trading menganalisis limbah hasil produksinya agar memenuhi ketentuan. Dari hasil analisis didapatkan bahwa limbah yang dihasilkan dari proses cutting dan sewing yang biasa disebut dengan majun, memiliki nilai jual. Selain itu sampah kertas hasil dari kegiatan administrasi perkantoran, cones yang digunakan untuk menggulung kain, plastik pembungkus kain, kardus dari hasil kiriman supplier yang digunakan untuk mengirim accessories juga memiliki nilai jual. Sehingga di PT. Shafco Multi Trading relatif tidak memiliki limbah hasil produksi. Agar laporan penjualan limbah hasil produksi dapat terpantau lebih baik lagi, dibuatlah sebuah sistem informasi berbasis web agar top level management dapat melihat berapa jumlah limbah yang dihasilkan dari satu job/design busana yang ingin dibuat dengan quantity yang telah ditentukan serta berapa hasil penjualan limbahnya.
Aerobic Capacity and Regular Physical Exercise among Tobacco Smokers
Authors: Alyafei Anees
Published: June 2021

Background: The Aerobic capacity is a well-recognized indicator for cardiopulmonary fi tness, which is aff ected by many factors, including tobacco use. Tobacco smoking is also known for its toxic eff ects on the cardiopulmonary system. Thus, aerobic capacity change is an exciting area for discussion among tobacco smokers, parallel to the cardiopulmonary eff ect. There is signifi cant agreement that aerobic capacity is reduced in tobacco smokers and improves by regular physical exercise in a dose-related manner. Few scattered studies showed minimal or no eff ect of physical exercise on aerobic capacity. Further clinical trials need to assess the impact of physical exercise and related improving & suppresser factors on the aerobic capacity among tobacco smokers.
PERANCANGAN SISTEM APLIKASI PELACAKAN PENGIRIMAN PAKET POS BERBASIS WEBSITE CABANG PT. XWZ
Authors: Iskandar  , Muslim Adam Firdaus
Published: June 2021

Perkembangan teknologi pengiriman surat dan paket, merupakan faktor utama pendorong kemajuan bagi masyarakat dan negara. Kemudahan dalam pengiriman surat dan paket antar pulau dan negara membuat masyarakat semakin maju dan berkembang karena tidak harus datang ke tempat yang mereka ingin tuju, Penelitian ini bertujuan untuk mengusulkan pembaruan rancangan sebuah sistem Website untuk melacak keberadaan paket yang dikirim melalui ekspedisi PT. XYZ. Perancangan Website telah menghasilkan suatu rancangan Website untuk mendukung proses pelacakan paket, alur berjalannya paket, dan berupaya mempercepat proses update status kiriman paket. Pengembangan Perangkat lunak menggunakan metode Agile Framework Scrum dengan menggunakan bahasa pemrograman php dengan framework Codeigniter 4.0. Hasil evaluasi implementasi aplikasi menunjukan performance usability 76.26%, sehingga rata-rata penelusuran memerlukan waktu 15 second, sehingga dapat memperbaharui proses pengiriman dan penelusuran  paket menjadi lebih baik.
RANCANG BANGUN PERANGKAT SISTEM PANGGIL PERAWAT (NURSE CALL) BERBASIS MIKROKONTROLER ATMEGA8535 – DENGAN FITUR KOMUNIKASI
Authors: Djoko Nursanto  , Pria Sukamto  , Arif Eko Wicaksono
Published: June 2021

Perangkat sistem pemanggil perawat atau biasa disebut nurse call, wajib dimiliki oleh sebuah rumah sakit. Perangkat ini berada di ruang perawatan-inap pasien. Fungsi perangkat ini adalah untuk memanggil perawat yang berada di pos perawat apabila seorang pasien membutuhkan bantuan. Tombol panggil ada disamping tempat tidur pasien dan di kamar mandi. Dalam pedoman teknis yang diterbitkan oleh Departemen Kesehatan disebutkan bahwa perangkat nurse call harus memiliki kemampuan komunikasi audio antara perawat dan pasien akan tetapi ternyata tidak semua perangkat nurse call di rumah sakit memiliki memiliki fitur ini. Perangkat nurse call dengan fitur komunikasi biasanya harganya jauh lebih mahal. Tujuan penelitian yaitu membuat rancang bangun Perangkat Sistem Pemanggil Perawat menggunakan Mikrokontroler ATmega8535 sebagai pengendali utama. Rancangan yang dibuat diharapkan bisa memberikan alternatif penyediaan sistem pemanggil perawat/nurse call yang lebih ekonomis tetapi tetap efektif, efisien, dan mudah dalam perawatan. Penggunaan mikrokontroler dan komponen elektronika digital tanpa memakai komputer sebagai pengendali, membuat harga jauh lebih murah dan konsumsi daya listrik sangat kecil. Fitur komunikasi yang dimiliki oleh perangkat nurse call juga akan meningkatkan waktu tanggap dan menghemat tenaga kesehatan yang sedang bertugas di ruang rawat inap.
PERANCANGAN APLIKASI PESAN TANDING FUTSAL DENGAN METODE WATERFALL
Authors: Sumardiono  , Mus Mulyadi Maulana
Published: June 2021

Futsal merupakan salah satu jenis olahraga beregu atau berkelompok dan masuk cabang atletik dengan jumlah pemain dalam satu kelompok 5 pemain. Dengan banyaknya minat masyarakat akan olahraga sepak bola (futsal), lebih dari 30 club/team futsal se kecamatan Sindang. Sebanyak 60% dari jumlah itu menjadi pelanggan tetap di Vianos Futsal. Dalam satu minggu lebih dari 20 team/club menyewa lapangan. Jadi, untuk memudahkan penjadwalan dan pengaturan dalam penggunaan lapangan futsal (booking sarana), penulis merancang sistem pengaturan pinjaman lapangan dengan metode First Come First Serve (FCFS) yaitu pertama daftar, maka pertama dilayani. Dalam perancangan sistem informasi pesan tanding futsal, penulis melakukan beberapa metode pengembangan sistem yaitu dengan menggunakan metodologi SDLC. SDLC has a similar set of four fundamental phases: planning, analysis, design, and implementation. Dari hasil penelitian ini diperoleh rancang bangun aplikasi berupa aplikasi login dan register akun, aplikasi penyewaan, aplikasi laporan pemesanan, dan aplikasi atur jadwal. Tentunya masih terdapat kekurangan dalam sistem ini sehingga perlu adanya penelitian berikutnya untuk pengembangan sistem yang lebih baik
MANAJEMEN DATA PENDIDIKAN ANAK SECARA REAL-TIME DENGAN OPEN-SOURCE SMART REGISTER PLATFORM (OpenSRP)
Authors: Sudirman
Published: June 2021

Di Nusa Tenggara Barat, data tersebar di berbagai sektor namun belum ada pengelolaan data secara real-time. Kami membuat tahapan proses dalam merancang sistem manajemen data tepat waktu untuk mendukung pertumbuhan, perkembangan dan pendidikan anak. Studi formatif dilakukan di Kabupaten Lombok Barat dan Kabupaten Lombok Timur secara random sampling untuk mengumpulkan informasi pada 1059 orang tua anak atau pengasuh  melalui pemetaan data, wawancara mendalam, pemeriksaan dokumen, dan entri data  secara langsung menggunakan Open-source Smart Register Platform (OpenSRP). Untuk memperoleh gambaran lengkap tentang pendidikan dan tumbuh kembang anak dihubungkan dalam satu platform. Penelitian ini menggunakan Open-source Smart Register Platform (OpenSRP) untuk manajemen data pendidikan menggunakan tablet PC atau smartphone.  Data dapat dengan mudah dimasukkan kapan saja secara tepat waktu menggunakan Enketo form. Jika infrastruktur jaringan internet belum tersedia, platform ini juga memungkinkan untuk memasukkan data secara offline dan dapat secara otomatis tersimpan pada server database ketika koneksi jaringan tersedia. Segera setelah entri data selesai platform ini menyediakan dashboard yang berisi laporan data secara real time yang dapat diakses oleh pemangku kepentingan di setiap tingkatan. Untuk menghindari penyalahgunaan data, akses tersebut juga akan dibatasi dengan sistem login yang aman. Berdasarkan studi formatif ini, OpenSRP dapat diterapkan untuk manajemen data pendidikan secara tepat waktu sesuai dengan indikator nilai rata-rata pengiriman data tepat waktu sebesar 93,39%, kualitas dan kelengkapan data sebesar 83,94%
APLIKASI SOFTWARE UNTUK MONITORING BAHAN BAKU PADA PERUSAHAAN PENGOLAH REMPAH-REMPAH
Authors: Sobarnas Mohamad Anas , Suherwin  , Ashari Imamuddin
Published: June 2021

Kesesuaian pembelian bahan baku dengan proses produksi sangat krusial agar tidak terjadi penumpukan bahan baku. Hal ini akan menghilangkan masalah bahan baku yang tidak terpakai dalam proses produksi dan menjadi rusak tidak layak pakai. Penelitian ini bertujuan untuk merancang sebuah aplikasi perangkat lunak untuk monitoring material (bahan baku) yang ada di gudang. Perancangan perangkat lunak berbasis Unified Modeling Language (UML) ini telah menghasilkan suatu rancangan perangkat lunak untuk mendukung  proses pengecekan bahan baku, permintaan barang, pembuatan PO, penerimaan barang, pengeluaran barang, dan pelaporan stock opname. Hasil evaluasi oleh calon pengguna perangkat lunak ini disimpulkan bahwa rancangan ini telah memenuhi kebutuhan perusahaan dan perlu diimplementasikan menjadi working system sehingga dapat mendukung proses bisnis perusahaan
SISTEM PENJUALAN DARING BERBASIS WEB PADA PERUSAHAAN MODE PAKAIAN
Authors: Ivan Rifki Nur Alif  , Pria Sukamto  , Imamuddin Ashari
Published: June 2021

Studi ini dilakukan di sebuah perusahaan mode pakaian yang kegiatan usahanya menjual produk fesyen (mode pakaian) secara langsung kepada pembeli melalui toko-tokonya. Pemilik bisnis perusahaan ini ingin mengembangkan melalui penjualan daring. Penelitian ini dilakukan untuk merancang sebuah sistem penjualan daring berbasis web pada perusahaan tersebut dengan memanfaatkan peluang bisnis menggunakan metode ini. Metode penelitian ini adalah pengumpulan data dengan studi literatur/pustaka dan interview (wawancara) kepada pemilik dan karyawan perusahaan, analisis sistem dan perancangan sistem. Dari penelitian ini dihasilkan sebuah rancangan sistem penjualan daring berbasis web yang telah diverifikasi dan divalidasi bersama dengan calon pengguna sistem ini. Rancangan ini dapat dijadikan sebagai landasan dalam pengembangan sistem penjualan pada perusahaan sehingga dapat meningkatkan penjualan perusahaan.
Evaluation of the corrective effect of therapeutic plasmapheresis on the state of renal function in patients after surgical treatment of localized kidney cancer
Authors: Dimitriadi S. N. , Ushakova N. D. , Velichko A. V. , Frantsiyants E. M.
Published: June 2021

Purpose of the study. To assess the state of renal function in the application of therapeutic plasmapheresis in order to correct the disorders accompanying the development of preclinical stage of AKI in patients after partial nephrectomy under conditions of warm ischemia.

Patients and methods. We examined 119 patients (average aged 57.6±7.8 years) from 2018 to 2019, who underwent open or laparoscopic kidney resection for cancer according to elective indications and with the usage of standard WIT technique within 15-21 minutes. Patients with a high risk of developing a clinical stage of AKI (n=21) were divided into 2 groups: in group I (n=10), patients continued to receive standard nephroprotective therapy, in group II (n=11), 24 hours after surgery, therapeutic plasmapheresis was performed according to the TPE (Therapeutic plasma exchange) protocol. During 7 days after the surgery patients in both groups were monitored daily for the rate of hourly diuresis, serum creatinine, and creatinine GFR. The presence of significant differences in the groups was evaluated using the STATISTICA 12.6 software package and the differences between the samples were considered significant at p<0.05.

Results. The development of the clinical stage of AKI in group I was detected in 80.0 % of cases, in group II in 9.0 % of patients (p=0.0019). The rate of diuresis in group II was significantly higher: by more than 2 times by day 3, by 90.0 % on day 4, by 81.4 % on day 5, by 36.8 % on day 6, and by 25.4 % on day 7 (p<0.05). The average increase in creatinine in group I was significantly higher: more than 5 times on day 5 and more than 4 times on day 6 and 7 of the study (p<0.05). GFR in group II was significantly higher on day 3 (65.3 %), day 5 (54 %), day 6 (39.2 %) and day 7 (50 %) (p<0.05).

Conclusion. Therapeutic plasmapheresis is highly effective in the correction of renal function disorders after kidney resection under WIT conditions and demonstrates an advantage in reducing the risk of developing a clinical stage of AKI in comparison with preventive measures that include standard nephroprotective infusion therapy.
Radical removal of advanced cancer of the oral cavity and oropharynx
Authors: Svetitskiy P. V.
Published: June 2021

Surgery for advanced cancer of the oral cavity and oropharynx are among the most difficult. This is due to the topographical and anatomical features that limit the operating field and the proximity of the internal carotid artery, which penetrates into the skull without branches. Her injury and bandaging are fraught with lethality. In the postoperative period, due to a violation of the function of swallowing, there is a stagnation of oral fluid in the oral cavity, which pro[1]motes healing by secondary tension. The functions of the oropharynx are impaired: swallowing, chewing, breathing and speech.

Purpose of the study. To develop an operation in patients with advanced cancer of the oral cavity and oropharynx, allowing to visualize the area of the tumor with it’s radical removal and postoperative healing without suppuration.

Patients and methods. We’ve operated a patient with advanced cancer of the oral cavity and oropharynx with me[1]tastases to the cervical lymph nodes (T4 N1 M0 – IV st.). Cervical lymphodessection and removal of the tumor from the oral cavity and oropharynx was performed according to the method developed at the National Medical Research Centre for Oncology of the Ministry of Health of Russia: the tumor was removed after a preliminary modified mandib-ulotomy. Good visualization allowed for a radical operation, after which a urostoma was formed, which promotes the free flow of oral fluid from the oral cavity, without its stagnation and without suppuration of the tissues. The jaw was restored with two titanium mini-plates.

Results. The healing was carried out by primary tension. On the 7th day after the operation, breathing was restored[1]decanulated. On day 20, epithelialization of the wound surface of the oral cavity and oropharynx occurred. The nasoesophageal probe was removed. Plastic orostoma was produced. By this time, the functions of the oropharyngeal region were partially restored: chewing, swallowing, and speech. Discharged home. Remission for more than 2 years.

Conclusions. Previously performed modifi ed mandibulotomy in patients with advanced cancer of the oral cavity and oropharynx, allows you to expand the view of the operating field and provide a radical operation. The formed orostoma, preventing suppuration in the oral cavity, accelerates healing with the restoration of functions: chewing, swallowing, breathing and speech.
Orthopedic treatment in cancer patients with maxillofacial pathology
Authors: Pustovaya I. V. , Engibaryan M. A. , Svetitskiy P. V. , Aedinova I. V. , Volkova V. L. , Chertova N. A. , Ulianova Yu. V. , Bauzhadze M. V.
Published: June 2021

Relevance. Staged orthopedic treatment was used to improve the quality of life of patients who underwent radical maxillofacial surgeries for cancer.

Patients and methods. 197 patients receiving treatment for maxillofacial cancer were observed at the Department of head and neck tumors, National Medical Research Centre for Oncology of the Ministry of Health of Russia, in 1998- 2018. All patients underwent radical surgical treatment resulting in postoperative defects of the upper jaw, soft tissues of the zygomatic- buccal-orbital region, nose, or auricle.

Results. Removable obturator prostheses with various supporting and retaining elements were made for 159 (80.7 %) patients. Individual facial prostheses were made for 38 (19.3 %) patients: 17 (44.7 %) – external orbital prostheses, 14 (36.8 %) – external nasal prostheses, 6 (15.8 %) – external zygomatic- buccal-orbital prostheses, 1 (2.7 %) – external auricle prosthesis. Combined prostheses were made for 4 patients– removable upper jaw obturator and nose prosthe[1]sis; removable upper jaw obturator and eye prosthesis. Combined prostheses were fixed to each other using magnets. The results of maxillofacial prosthetics were evaluated according to the aesthetic requirements of the patients and their quality of life. Maxillofacial prostheses allowed a complete restoration of chewing, swallowing, and speaking, restored facial deformation, and improved the appearance of patients.

Conclusions. Timely and comprehensive orthopedic treatment of patients with postoperative maxillofacial defects after radical surgeries for malignant tumors takes the main place in the complex of rehabilitation measures. Early elimination of extensive defects is aimed at maximum restoration of oral dysfunctions and appearance preservation. The apparent advantages of maxillofacial prostheses involve improvement of social adaptation and the quality of life of patients, which promotes complete rehabilitation and a return to socially useful activities.
The use of immunotherapy for the treatment of refractory forms of Hodgkin lymphoma in real clinical practice.
Authors: Kamaeva I. A. , Lysenko I. B. , Nikolaeva N. V. , Pushkareva T. F. , Kapuza E. A. , Gaisultanova Ya. S. , Velichko A. V.
Published: June 2021

With a frequency of 2.2 cases per 100,000 population in Russia, Hodgkin's lymphoma (HL) is one of the most common malignant neoplasms in young people. In connection with the predominant spread of HL among young people, the issue of effective treatment of various forms of HL remains relevant. Currently, 70-90 % of patients with HL who have received standard chemotherapy or chemoradiotherapy have a long period of remission. However, 10 % of patients with progressive course, can`t achieve a response, and 30 % of patients subsequently recur. The standard approach of treating recurrent and/or refractory HL after initial treatment is “salvage therapy” followed by consolidation with high-dose chemotherapy and stem cell transplantation. Although there is a model for treating these patients, recent research has focused on improving the effectiveness and tolerability of rescue therapy. The use of anti- PD-1 drugs opens up new possibilities for the treatment of recurrent/refractory HL. The article describes the results of using checkpoint inhibitors for patients with a history of multi- course chemotherapy. Inhibitors of immune check points were supplemented in the 3rd and subsequent lines of ChT. A clinical case with immunotherapy supplementation in a patient with severe comorbidity is also presented.
Optimization of anesthetic tactics in the surgical treatment of multiple primary non-small cell lung cancer
Authors: Tikhonova S. N. , Rozenko D. A. , Ushakova N. D. , Popova N. N. , Skopintsev A. M. , Shulga A. V. , Ten I. A.
Published: June 2021

The article describes a clinical case of surgical treatment of a patient with multiple primary malignant lesions of the lungs (cancer of the left lung, central peribronchial nodular tumor with involvement of the upper lobe and distal parts of the main bronchus; cancer of the right lung, central tumor with involvement of the upper lobar bronchus). Radical treatment became possible due to using the potential of artifi cial gas exchange of both lungs with two devices with fundamentally different ventilation mechanics. The choice of an optimal tactics for the functional correction of the supposed hypoxemia by volumetric and high-frequency pulmonary ventilation allowed avoiding an imbalance in the ventilation/perfusion ratio and preventing the development of life-threatening complications, as well as ensured an adequate gas exchange for the patient during surgical treatment.
Molecular genetic classification of colorectal cancer subtypes: current state of the problem
Authors: Kit O. I. , Dzhenkova E. A. , Mirzoyan E. A. , Gevorkyan Yu. A. , Sagakyants A. B. , Timoshkina N. N. , Kaymakchi O. Yu. , Kaymakchi D. O. , Tolmakh R. E. , Dashkov A. V. , Kolesnikov V. E. , Milakin A. G. , Poluektov S. I.
Published: June 2021

Today, colorectal cancer (CRC) is the third most common cancer and therefore an urgent problem of oncology. Despite all modern diagnostic capabilities, the rates of advanced cases are growing steadily. CRC was proven to be a result of a phased dysplastic change in the colon mucosa, molecular genetic changes that determine the molecular biology of the tumor, its properties, morphology, disease prognosis and response to therapy. The following mechanisms of CRC tumor progression are distinguished: chromosomal instability, microsatellite instability, "methylator" phenotype, and serrated pathway of adenocarcinoma development. Application of molecular and diagnostic methods has become a promising direction in recent years. This led to the development of a molecular genetic classifi cation with 4 CRC subtypes differing not only in their molecular genetic characteristics, but also in clinical course and response to therapy.
Pollination in the Tropics: Role of Pollinator in Guava Production
Authors: OMAR Nurul Alia , ZARİMAN Nur Athirah , NURUL HUDA A.
Published: June 2021

Pollinators are the key point for successful pollination in most flowering plants around regions where around 90% depend entirely on pollination. Majority of the pollinating species are wild, comprising bees, certain species of flies, wasps, moths, butterflies, thrips, beetles, bats, birds and other vertebrates, and among them insect pollinators are the most crucial. Fruit crops benefit in an impressive way from insect pollination, where there is a remarkable improvement both in the productivity and the quality of self-fertilized, self-incompatible and cross-cropping crops worldwide. The pollinators are responsible for assisting these flowering plants with their reproduction. However, the crisis of the wild and managed pollinators has attracted the attention of the world, which could seriously disrupt pollination activities and the ecosystem. Despite the growing concern about the decline in pollinators worldwide, issues remain uncertain as data are often limited and undermined. Guava Psidium guajava is a marketable fruit culture in numerous tropical and subtropical regions around the world. There has been a growing interest in pollination studies on guava because of its great economic importance. In guava, self-pollination is evident, however, they benefit greatly from insect pollination. This article aims to provide an overview of tropical pollination and pollination problems that have occurred around the world with a focus on pollination activities in guava.
Fermented Traditional Probiotic Beverages of Turkish Origin: A Concise Review
Authors: ALADEBOYEJE Oluwaseun , ŞANLI Nazmiye Özlem
Published: June 2021

ABSTRACT:

The fact that foods can provide additional medicinal health benefits beyond basic energy requirements and nutritional needs for survival, has been proven through rigorous scientific researches over the years. Although Turkey is historically believed to be the ancient origin of a decent number of fermented probiotic foods and beverages, there is still little awareness amongst the overall populace regarding the usefulness of these medicinal products also known as functional foods. Hence, the current review article discusses probiotics as a top notch variety of functional foods and encapsulates their history as well as some proven beneficial effects of some known probiotic microorganisms on human health. More importantly, greater emphasis is placed on elucidating scientific data on seven fermented traditional probiotic beverages of Turkish origin namely boza, kefir, ayran, shalgam, hardaliye, koumiss and gilaburu juice. The paper concisely describes their main characteristics, probiotic microbiota composition, production techniques as well as nutritional properties and some potential health benefits derivable from their consumption.
The most common bacterial isolates from wound samples – a three-year study
Authors: Kaftandzieva Ana , Kostovski Marko , Mehmeti Blerta , Mirchevska Gordana
Published: June 2021

Aim: The aim of our study was to determine the most common bacteria isolated from wound samples and tо compare the frequency of the resistant bacteria isolated over a 3-year period. Material and methods: During a three years period (2017-2019) a total of 11 863 wound samples (wound swabs, punctuates, exudates, tissue, etc.) were obtained from the hospitalized patients in the University Clinics of the ,,Mother Theresa” campus, the City hospital ,,8th September” and the University Clinic for surgical diseases ,,St. Naum Ohridski” in Skopje. All samples were processed at the Institute of Microbiology and Parasitology, Faculty of Medicine, Skopje. They were examined by standard microbiology techniques. Identification and susceptibility of microorganisms were done by both standard methods and automatized Vitek 2 system. Results: Out of a total number of samples, which was 3 463 in 2017, 4 127 in 2018 and 4 273 in 2019, positive were 2 068 (60%), 2 302 (55.8%) and 2 387 (55.9%), respectively. From the total of aerobes/facultative anaerobes (2 758, 2 949 and 3 279 in three consecutive years, 2017, 2018 and 2019, respectively), Staphylococcus aureus was the most predominant isolate (19.5%, 16.6%, 16.9%) followed by Enterococcus spp (16%, 16%, 16.7%), Pseudomonas aeruginosa (12%, 13%, 12.7%) and E. coli (10%, 10.4%, 10.7%). Considering anaerobic bacteria, the percentage of Gram positive anaerobes (Peptostreptococcus) has decreased from 33% to 18% out of a total number of anaerobes, unlike Gram negative anaerobes in which the increasing percentage was mostly observed in bacteria of the genus Bacteroides (from 39% to 45%). The percentage of the resistant strains of MRSA, CNS-MR and VRE was almost the same in that period. In Gram-negatives the percentage of ESBL-positive isolates of E. coli and Enterobacter spp. increased consecutively from 2017 to 2019. The increase in the percentage of resistant strains was more noticeable in ESBL-positive isolates of Klebsiella pneumonia between 2017 and 2018, but in 2019 a percentage decrease can be observed. Considering carbapenem-resistant (CR) Enterobacterales, an increase in the resistance was noticeable in K. pneumonia. The increase in the percentage of resistant strains in Enterobacter spp. between 2017 and 2018, as well as the decrease between 2018 and 2019 was statistically significant. The percentage of CR-isolates of Pseudomonas aeruginosa was from 30% to 38% and for Acinetobacter spp. this percentage was from 81% to 85%. Conclusion: The knowledge of the most commonly isolated bacterial pathogens, especially the presence of resistant bacteria, is crucial and should be continuously monitored in order to understand, construct and update effective treatment algorithms and guidelines.
Changes in weight status of 7-year-old children in North Macedonia between 2010 and 2019
Authors: Spiroski Igor , Mikik Vladimir , Miloradovska Natalija , Veljanovski Marjan , Shaqiri Jeton , Petrova Aleksandra , Dzikovska Biljana , Shahini Blerta , Kitanovska Spasev Julijana
Published: June 2021

Childhood obesity is growing as one of the most important public health issues that affects individual and population health but also puts heavy burden on the health systems. It is frequently associated with immediate adverse consequences, such as psychological problems, and a higher risk of many harmful comorbidities later in life, such as type 2 diabetes, dyslipidemia, non-alcoholic fatty liver disease, hypertension, and coronary heart disease. Comparability of anthropometric data is crucial to track the changes over time. The aim of this paper was to present prevalence of thinness, overweight, and obesity in 7-year-old schoolchildren in North Macedonia in 2010 and 2019, and the changes in their nutritional status during thatperiod. Material and methods: Anthropometric measurements of body height and body weight were performed to the nationally representative sample of 7-year-oldchildren in school years 2010/2011 and 2018/2019. Measurements followed the Childhood Obesity Surveillance Initiative (COSI) protocol and data collecting procedures. In total, 2737 children (1317 girls and 1420 boys) in 2010 and 2059 children (1045 girls and 1014 boys) in 2019 were measured. WHO Growth references were used to determine the growth and nutritional status of children. Results: The average height of children in the observed period has increased by 1.7 cm, weight for 1.2 kg and the BMI for 0.3 kg/m2. As for the weight classification, thinness prevalence is significantly increased for 0.3%. Overweight (including obesity) significantly increased (p=0.0377) from 34.4% (95% CI 32.6%-36.2%) in 2010 to 37.3% (95% CI 35.2%-39.5%) in 2019. Obesity significantly increased (p=0.040) from 16.3% (95% CI 14.9%-17.7%) in 2010 to 18.4% (95% CI 16.7%-20.1%) in 2019. The main driver of that increase was the highly significant (p=0.0004) increase of almost 7% of overweight (including obesity) in girls. Conclusion: There is unfavorable rising trend which indicates deterioration of the situation with childhood obesity in the country. Focused and more comprehensive public health nutrition actions are needed to plateau or reverse the trends. The childhood obesity national monitoring system is well established and should continue to beone of the key public health monitoring systems that provide evidence for actions.
Influence of alendronate therapy on the results of densitometric examination after implantation of total hip endoprosthesis
Authors: Shabani Ilir , Gavrilovski Antonio , Velkovski Vilijam , Atanasov Nenad , Memeti Shaban , Belchishta Anila
Published: June 2021

The development of aloarthroplasty of the hip is continuously rising. After implantation of a total cement-free hip endoprosthesis, often there is a periprosthetic femoral bone loss. Alendronate has been shown to be a potent inhibitor of bone resorption activity; it inhibits osteoclastic bone resorption, increases bone mass, and plays a significant role in post-implantation stabilization of the femur. The aim of this study was to determine the effect of alendronate on osteointegration of hip endoprosthesis.Material and methods: The study analyzed 10 patients operated on with implantation of a total cement-free hip endoprosthesis (THP). The included patients were examined by a radiographic method at 6 and 12 months and DXA method at 6 and 12 months. Results: The study showed differences in the values of bone mineral density and bone mineral content in the interval between 6 and 12 months in patients undergoing THP, and hence we can conclude that alendronate therapy after THP implantation reduced periprosthetic loss of bone mass and implant stiffening. Alendronate is a proven inhibitor of periprosthetic bone loss that occurs after prirmary impantation of a total cement-free hip endoprosthesis.
Relationship of serum procalcitonin levels and c-reactive protein levels in newborns with sepsis in different types of respiratory support in intensive care unit
Authors: Sofijanova Aspazija , Bojadzieva Sonja , Naunova- Timovska Silvana , Mandzukovska Hristina , Shuperliska Elizabeta , Jordanova Olivera
Published: June 2021

Sepsis in newborns with RDSy and asphyxia is essential; it is a life-threatening condition and still represents an important cause of mortality and morbidity. The aim of this study was to evaluate the predictive values of procalcitonin (PCT) as an early diagnostic and prognostic biochemical marker for sepsis in newborns with RDS and asphyxia. Material and methods: The study was designed as prospective and we examined 110 newborns with proven sepsis admitted in the Intensive  Care Unit at the University Clinic of Pediatrics – Skopje in the period between December 2018 and Јanuary 2021. Procalcitonin levels were measured by using the immunoassay system Vidas based on the ELFA principles. The newborns with proven sepsis were divided into two groups. The first group comprised 55 newborns with RDS and proven sepsis and the second group included 55 newborns with asphyxia and proven sepsis. The statistical analysis confirmed significantly different values ​​of PCT in the analyzed time period in first group of newborns with RDS and proven sepsis, p<0.001. The highest average values (40.37±53.79) ​​were measured on admission with a high level of peak compared to the second group of newborns with asphyxia and proven sepsis. The statistical analysis confirmed significantly different values ​​of PCT in the analyzed time period in the first group of newborns with RDS and proven sepsis with mechanical ventilation (MV) and bubble continuous positive airway pressure (BCPAP) compared to the second group of newborns with asphyxia  and proven sepsis,  p<0.001. PCT is a promising sepsis marker in newborns with RDSy, capable of complementing clinical signs and routine laboratory parameters suggestive of severe infection at the time of ICU admission.
Оral hygiene and fluoride influence on dental health in early childhood
Authors: Kokoceva-Ivanovska Olga
Published: June 2021

Early childhood caries occurs immediately after the eruption of deciduous teeth. During this period, children are too young to be able to properly implement oral hygiene. Consequently, it is at a negligible level, with plenty of soft plaque on the deciduous tooth surfaces. The objective of this investigation was to determine the correlation between oral hygiene (shown with the OHI index) and the initial stages of early childhood caries: initial lesion (white spot) and superficial form, before and after local fluoride treatment. Material and methods: For determining the OHI index among our examinees we used the method of Green-Vermillion. It was determined in 117 examinees twice, during the first visit and immediately before physiological replacement of deciduous teeth. Patients were two to three years of age, diagnosed with initial stages of early childhood caries and fluoride preparate (amino fluoride solution) was applied once a week, for 6 months. Results: In 30 subjects treated with local fluoride treatment from both basic groups (with initial and superficial lesions), just before the physiological change of the teeth, we received a statistically significant improvement in the OHI index (p = 0.000038; p = 0.00006) at the end from the examination. Conclusion: From the conducted analysis of the obtained results, we can conclude that the level of oral hygiene is correlated with the progression of changes in the enamel. Oral hygiene and fluoride treatment significantly reduce soft tissue levels and improve the OHI index.
Longstanding postoperative fluid collection influences recurrence of pancreatic malignancy
Authors: Kim Young Jung , Cheon Young Koog , Lee Tae Yoon , Chang Seong-Hwan , Yu Mi-Hye
Published: June 2021

Background/Aims: Postoperative abdominal fluid collection (PAFC) is a frequent complication of pancreatobiliary cancer surgery. The effects of the existence and duration of PAFC are not well known. This study aimed to assess the effects of PAFC on patient prognosis after surgery for pancreatobiliary adenocarcinoma and the association of longstanding PAFC with the recurrence of pancreatic cancer.Methods: We retrospectively analyzed the data of 194 consecutive patients with pancreatobiliary adenocarcinoma who underwent curative operations from August 2005 to December 2019. The presence of PAFC was assessed using computed tomography within a week of surgery; PAFC lasting > 4 weeks was defined as longstanding PAFC.Results: Among 194 patients, PAFC occurred in 165 (85.1%), and 74 of these had longstanding PAFC. The recurrence rate of pancreatobiliary adenocarcinoma was significantly higher in patients with longstanding PAFC than in patients with non-longstanding PAFC (p = 0.025). Recurrence was also significantly associated with high T stage (T3, T4; p = 0.040), lymph node involvement (p < 0.001), perineural invasion (p < 0.006), and non-receipt of adjuvant chemotherapy (p = 0.025). Longstanding PAFC was significantly associated with the recurrence of pancreatic adenocarcinoma (p = 0.016). However, cancer-specific survival was related to neither the presence nor the duration of PAFC.Conclusions: The presence of longstanding PAFC was associated with the recurrence of pancreatic adenocarcinoma. However, a larger prospective study is necessary to confirm the findings.
SMARCA4/BRG1 protein-deficient thoracic tumors dictate re-examination of small biopsy reporting in non–small cell lung cancer
Authors: Mehta Anurag , Bansal Divya , Tripathi Rupal , Jajodia Ankush
Published: June 2021

Background: SMARCA4/BRG1 protein–deficient lung adenocarcinomas and thoracic sarcoma are recently described entities that lack distinctive histological features, transcription termination factor 1 (TTF1) reactivity, and actionable driver mutations. The current diagnostic path for small lung biopsies as recommended by the World Health Organization (WHO, 2015) is likely to categorize these as non– small cell carcinoma–not otherwise specified (NSCC-NOS). The present study attempts to define the subtle but distinctive clinicopathologic features of SMARCA4/BRG1 protein-deficient thoracic tumors; highlight their unique biology; and addresses the unmet need to segregate these using a new, tissue-proficient diagnostic pathway.Methods: All lung biopsies and those from metastatic sites in patients with suspected advanced lung cancer and classified as NSCC-NOS as per WHO (2015) guidelines were subjected to BRG1 testing by immunohistochemistry. SMARCA4/BRG1 protein–deficient thoracic tumors were evaluated by an extended immunohistochemistry panel. Predictive biomarker and programmed death–ligand 1 testing was conducted in all cases.Results: Of 110 cases, nine were found to be SMARCA4/BRG1 protein-deficient; six were identified as SMARCA4/BRG1 protein–deficient lung adenocarcinomas, and three were SMARCA4/BRG1 protein-deficient thoracic sarcomas. The histology ranged from poorly differentiated to undifferentiated to rhabdoid. None of the cases showed significant expression of TTF1 or p40, and no actionable mutation was identified.Conclusions: It is difficult to separate BRG1-deficient lung adenocarcinomas and thoracic sarcomas based on morphology alone. We propose a diagnostic pathway for small biopsies of thoracic tumors to segregate these distinct entities so that they can be studied more efficaciously for new biomarkers and therapeutic options.
Lessons from COVID-19 Pandemic: A Preliminary Analysis of Bangladesh’s Responses
Authors: Mahmud Rifat
Published: June 2021

The first wave of the COVID- 19 disease has caused a daunting and unprecedented challenge for governments of the world. Decision-makers worldwide, including that of Bangladesh, had to initiate responses that were beyond the conventional measures. This paper offers the decision-makers in Bangladesh on the possible learning in the field of crisis management during this pandemic. The paper aims in focusing on the first phase of responses to COVID-19 (March-May) from the initial lockdown to the reopening of offices by the government of Bangladesh. Methodologically, the paper is a content analysis involving netnography approach of data collection from websites. The paper presents a finding of possible lessons of crisis responses in Bangladesh. The paper aims to create an agenda for learning lessons from the situation of the largest crisis to hit the world in centuries. The paper induces substantial value for policy-makers to be prepared for the second wave of the COVID- 19 crisis, to meet the challenges of the pandemic.
Geçmişteki Gelecek: Bilimkurgudaki Gerçeğin Mimarlık ve Kentin Gerçekliği Üzerinden Okunması
Authors: SOFTAOGLU Hidayet
Published: June 2021

Teknolojinin her geçen gün gelişmesiyle, mimarlık ve tasarım alanlarında da sürekli gelecek senaryoları üretilerek, alternatif mekânlar kurgulanmaktadır. Teknolojik destekle modellenen bilim kurgu setleri, sanal gerçeklik ve arttırılmış gerçeklik aracılığıyla mevcut düzende elde edilemeyen deneyimler sunulmaktadır. Oysa bilim ve teknoloji desteğiyle kurgulanan alternatif mekân arayışı, bugüne özgü olmayıp endüstriyel devrimle başladığı ve 19. yüzyıl ile üst düzeye ulaştığı William Heath tarafından 1829’da üretilen Akıl Yürüyüşü karikatüründe de görülür. Heath’ten günümüze; gerçeklik sınırlarını zorlayarak üretilen bu mekânlarda her şey sahte, sanal ya da kurgusal mıdır, yoksa bu gerçek dışılık ardında bir gerçek var mıdır, net bir biçimde sunulmaz. Lacan gerçeği mevcutta var olmayan bir gerçekliği yaratma arzusu ve bu arzuyu formüle ederek şekillendiren düzeni olarak tanımlar. Fantastik, teknolojik, gelecekçi mekânların ortaya çıkmasının ardında yatan sebep olan gerçek her zaman gizli olup kurgu tarafından maskelenmiştir. Bu maskenin kaldırılmasını ve gerçeği yani kurgusal mekânı formüle eden dışsal etkiyi aramak için bu makalede erişilebilen en erken kentsel, mimari bilim kurgusal görüntü olan William Heath’in Akıl Yürüyüşü karikatürü ele alınarak kurgudaki gerçeklik yerine kurgunun gerçeği araştırılmıştır. Bunu yaparken çağdaş filozof Slavoj Zizek’in Lacancı psikanalize dayanan trilojisi; imgesel gerçek, simgesel gerçek ve gerçek gerçek kavramları kullanılarak, gerçek üç kategoride incelenmiştir. Sonuçta geçmişteki geleceğin iletişime dayalı bir etki alanıyla kurgulandığı saptanmış ve Zizek’in trilojisi gerçeği aramakta kullanılabilecek bir yöntem olarak önerilmiştir.