bluuebunny/crossref_metadata_2025 huggingface dataset:
2D Interfacial Crystallization Stabilized by Short-Chain Aliphatic Interfaces
Authors: W. A. Swanson Hamish , Barriales Kenny , A. Sherman Emmet , Li Tai-De , R. Kennedy Alan , Tuttle Tell , V. Ulijn Rein , Hang Aaron Lau King
Published: September 2024

We report the formation of interface sealing crystalline sheets based on amino acid and peptoid-monomer amphiphiles. This process, interfacial crystallization (IFC), is demonstrated using a range of halide salts of amidated peptoid monomers and amino acid amide bases with varied aliphatic sidechains. In our investigation, we identified that sufficient dynamic freedom of attached sidechains is a crucial design principle underpinning the viability of IFC for a given molecule. In addition, our results indicated that a combination of ionic coordination, hydrogen bonding and dispersion interactions all contribute significantly to the formation of these structures, and they are consistent with a hypothesis of interfacial ion migration playing a critical role in structure formation. A comprehensive range of techniques, including AFM, FT-IR, TOF-SIMs, X-ray crystallography, salt exchange experiments, quantum mechanical (QM) calculations and molecular dy-namics (MD) simulation studies were used to characterize this phenomenon. The formation of these hierarchical nanostructures, and the simplicity of the chemistry involved, suggests that IFC may have applications in formation of 2D supramolecular materials and barriers.
Avanços e perspectivas da investigação do tema mobilidades no contexto brasileiro
Authors: Machado da Silva Elisangela Aparecida , Araújo Sobrinho Fernando Luiz , Santos Peixoto Nathane Eva
Published: September 2024

O paradigma das novas mobilidades emerge tornando-se uma linha de condução nas pesquisas contemporâneas onde, contraditoriamente, movimento e estática se confundem e consubstaciam o viés das investigações, desvelando abordagens críticas e humanísticas de forma a exacerbar as relações entre transporte e sociedade, bem como a aplicação de conhecimentos à transformação da realidade e das limitações de mobilidade de parte da população brasileira. Embora o tema ganhe repercussão, com relativa sistematização do conhecimento sobretudo na Inglaterra, no Brasil a temática ainda é pulverizada em diversas áreas do conhecimento, porém com baixa relação interdisciplinar. A utilização dessa terminologia em diferentes abordagens difi culta a compreensão do objeto de análise, a começar pela defi nição conceitual de mobilidade. Metodologicamente, foi conduzida uma revisão sistemática da literatura com análise de conteúdo e utilização do Software Iramuteq. Foram analisadas produções dos cursos de pós-graduação Stricto Sensu brasileiras – em Geografi a, Turismo e Engenharia de Transportes-, identifi cadas no título com o tema mobilidade. Os resultados apontam os tipos de mobilidades abordados, orientadores e instituições de ensino superior, a sistematização da produção e, ainda, identifi cam, ante ao estágio atual das pesquisas, o paradigma como oportuno para confi guração de novas redes de pesquisa necessárias para entender a mobilidade – não como reduto, mas como uma norma emergente, e que requer convergência. O termo, no campo da Geografi a, gradativamente, é incorporado à ideia de circulação das pessoas em ambientes urbanizados, embora vista assim, mobilidade é mais que o simples ato de transportar: é uma ação de valor, interpretada por meio do movimento físico; da representação; da prática e do (re)ordenamento espacial que se faz e refaz a cada instante em razão do ato de se movimentar. Enquanto as (i)mobilidades encontram-se relacionadas ao tempo dos deslocamentos, às diferenças e convergências entre lugares e aos grupos sociais, mas também, na busca por dirimir as barreiras de impedâncias físicas, sociais e ético-políticas quando o foco é a integração ou a conectividade espacial. Em suma, pensar em uma nova perspetiva de mobilidade implica refl etir sobre a produção de conhecimento em relação a vida móvel no mundo em permanente processo de transformação espaço-temporal, bem como nos aspectos inerentes a fundamentação teórico-conceitual. Dentre as abordagens futuras destaca-se a construção de constructo teórico de caráter interdisciplinar, que considere complexas e diferentes especifi cidades de análise, ou seja, métodos que avaliem a mobilidade em seus diversos aspectos.
Modernização antagônica do território no sudeste paraense: uma análise do circuito inferior em Parauapebas-PA
Authors: Silva Reis Walison , Macedo de Sousa Jailson
Published: September 2024

O presente artigo tem como proposta discutir o circuito inferior da economia urbana do município de Parauapebas-PA, local este que sedia os principais projetos de mineração do Sudeste do Pará, comandado pela Companhia Vale S.A. Parauapebas tem conjugado as contradições das atividades modernas da política mineradora, focadas no comércio externo, e as pequenas atividades não modernas, pouco capitalizadas e de baixa organização, ligadas à vida local da cidade e/ou da região, constituindo-se, desse modo, um espaço antagônico. A discussão do artigo mostra-se relevante por contribuir no entendimento da organização das atividades do circuito inferior da cidade de Parauapebas, como também por demonstrar que tais atividades são geradoras de empregos e renda, condição esta não restrita somente à moderna indústria mineradora.
Component Blood Transfusion with Restrictive Fluid Resuscitation in Ectopic Pregnancy Hemorrhage with Hemorrhagic Shock
Authors: Niu Ben , Wang Le
Published: September 2024

Objective: To study the effect of using component blood transfusion with restrictive fluid resuscitation in ectopic pregnancy hemorrhage complicating hemorrhagic shock. Methods: 50 cases of ectopic pregnancy hemorrhage complicating hemorrhagic shock were selected for data study, and after grouping, 25 cases in each group were grouped, and the use of component blood transfusion with restrictive fluid resuscitation was used in the study group and restrictive fluid resuscitation was used in the control group, and the differences in the data were compared. Results: Compared with the control group, the study group had a significantly higher resuscitation success rate, significantly fewer complications, significantly higher hemodynamic indexes 2 h after treatment, significantly better coagulation function indexes, and significantly fewer various quantities in the therapeutic situation, P < 0.05. Conclusion: The use of component blood transfusion with restrictive fluid resuscitation in ectopic pregnancy hemorrhage-complicating hemorrhagic shock has an ideal effect.
Early Intervention Facilitates Neuropsychological Development in Children with Autism and Attention Deficit Hyperactivity Disorder
Authors: Li Bei
Published: September 2024

Objective: This study aims to investigate the impact of early intervention on neuropsychological development in children with autism and attention deficit hyperactivity disorder (ADHD), providing effective intervention strategies for clinical practice. Methods: A total of 130 children with autism and ADHD who visited the hospital between June 2023 and June 2024 were selected as study subjects and randomly divided into an intervention group and a control group, with 65 children in each group. The intervention group received a one-year early comprehensive intervention, including behavioral therapy, cognitive training, and family guidance, while the control group only received routine medical care. The neuropsychological development assessment scale was used to evaluate both groups before and after the intervention to compare changes in their neuropsychological development levels. Results: Children in the intervention group showed significant improvements in cognitive function, social skills, language ability, and attention concentration, with an average improvement score of 23.5 points. Children in the control group did not show significant improvements in these areas, with an average improvement score of only 5.8 points. The difference between the two groups was statistically significant (P < 0.05). Conclusion: Early comprehensive intervention has a significant promoting effect on the neuropsychological development of children with autism and ADHD. Targeted behavioral therapy, cognitive training, and family guidance can effectively enhance children’s cognitive, social, language, and attention abilities, laying a solid foundation for their future overall development. Therefore, it is recommended to actively promote and apply early intervention strategies in clinical practice.
Effect of EditGPT on the Learners` Autonomy and Learning Anxiety
Authors: Jubier Mustafa Mahdi , Al-Rawe Marwah Firas Abdullah , Algaithi Ali
Published: September 2024

Recently, the use of automated writing applications has increased in English writing instruction. Therefore, this study aimed to measure the effect of using an automated writing evaluation system, called EditGPT, on learning anxiety and learners' autonomy. Thirty Omani EFL learners were selected as participants of this study in two equal groups of control and experimental groups. Pre-tests were conducted to ensure homogeneity of the groups. The data was used to collect the foreign language anxiety (FLA) questionnaire and autonomy scales developed by Horwitz et al. (1986) and McCrocklin (2016). The experimental group used the EditGPT AI (artificial intelligence) application during the treatment period. After treatment, post-tests were performed to measure discrepancies in the results. The findings of the study revealed that, in the post-test, the experimental group showed less anxiety and more autonomy than the control group. The results of this study will be helpful to both students and teachers.
Enhancing Reading Literacy in Thai Grade 2 Students through Active Learning Activities
Authors: Nandee Sasithon , Intasena Autthapon , Srimunta Thussaneewan
Published: September 2024

The purpose of this study was to investigate the effectiveness of employing a comprehensive active learning management plan in enhancing reading literacy among 2nd-Grade students in Thailand. The participants were 24 English as a foreign language (EFL) students in Thailand, selected through cluster random sampling. The research instruments included a learning management plan featuring a mix of active learning activities, including game-based learning, interactive storytime, story swap, and comprehension puzzles, and a pre–post reading literacy test. Data were analyzed using percentages, mean score, standard deviation, learning management effectiveness (E1: E2), the Effectiveness Index (E.I.), and a paired samples t test. The results show that active learning is effective, with students’ post-test scores being significantly higher than their pre-test scores. This study contributes to the existing body of evidence supporting active learning in primary school language classrooms. It highlights the benefits of incorporating a variety of active learning activities, rather than relying on a single approach, to enhance reading literacy.
Intervención en enfermería en reanimación cardiopulmonar pediátrica
Authors: García Vega Jefferson Benito , Chacha Uto David Gustavo , Quizanga Maldonado Carmen Janeth , Heredia Iza Martha Magdalena
Published: September 2024

La parada cardiorrespiratoria constituye una de las grandes emergencias médicas en todo el mundo, por tanto, también un importante problema de salud mundial. En niños es un evento infrecuente, no obstante, tiene una alta mortalidad y su pronóstico es multifactorial. En este sentido, la reanimación cardiopulmonar es un conjunto de intervenciones ejecutadas ante la constatación de una parada cardiorrespiratoria que consiste en maniobras de compresión torácica, ventilación, así como desfibrilación y el uso de fármacos con base en el ritmo de paro detectado. El personal de enfermería desempeña un papel fundamental dentro del equipo multidisciplinario que maneja estos eventos, ya que están más cerca del paciente en la realización de las maniobras. El propósito de la presente investigación es plasmar aspectos generales acerca de la intervención en enfermería en reanimación cardiopulmonar pediátrica. El enfoque metodológico de la investigación es una revisión bibliográfico – documental. La preparación constante y la actualización y seguimiento de intervenciones basadas en evidencia en el personal de enfermería está directamente relacionado con minimizar los retos relacionados con estos eventos. La detección temprana de la descompensación juega un papel fundamental en la prevención de la mayor parte de los paros cardiopulmonares en esta área. El manejo de la reanimación cardiopulmonar pediátrica se debe realizar en base a las guías internacionales y de cada país, incluso de cada centro hospitalario, ya que están realizadas en base a la mayor evidencia y unifica los criterios de manejo en busca de los mejores resultados.
Libros que hablan: Impacto de la literatura infantil en el desarrollo del lenguaje oral en niños de la Unidad Educativa Municipal del Milenio “Bicentenario”
Authors: Puchaicela Chicaiza Lida Elizabeth , Almagro Lascano Amparo Belén , Santillán Curillo Rocío del Pilar , Zaruma Suntasig Alba Marisela
Published: September 2024

La incorporación de la literatura infantil en las primeras etapas escolares se ha convertido en un pilar fundamental para transformar el paradigma educativo establecido hace décadas. Este cambio ha modificado el rol del docente y el objetivo en relación con el desarrollo infantil. Al introducir la literatura infantil a temprana edad, se fortalece el pensamiento, la imaginación, la creatividad, y las emociones de los niños, lo que les permite construir su conocimiento. Al enfocarse en el fortalecimiento y desarrollo del lenguaje oral a través de estrategias en el aula, se logran mejores resultados en la comunicación entre los niños y su entorno. Los docentes suelen utilizar más los cuentos, las canciones y las fábulas, dejando en segundo plano los trabalenguas, el teatro y las adivinanzas, a pesar de que estas formas literarias aportan de manera significativa al desarrollo de habilidades en los niños y niñas de 4 a 6 años; estas actividades ayudan a mantener la atención, acumular y retener información, e identificar palabras ocultas en el lenguaje, contribuyendo así al desarrollo del lenguaje oral. Es fundamental valorar todas las formas de la literatura infantil, ya que son esenciales para el desarrollo significativo de los niños. Esto no solo beneficia su formación y construcción de vocabulario, sino que también fomenta su autonomía, pensamiento crítico y capacidad para enfrentar la realidad y resolver problemas en su entorno. Implementar diversas formas literarias infantiles es, por tanto, un medio eficaz para promover y fortalecer su lenguaje, lo que resulta valioso para su vida cotidiana. El ambiente escolar es el espacio idóneo para que las niñas y niños desarrollen su lenguaje oral, les permitirá expresar sus emociones, necesidades, sentimientos y conocimientos, aspectos que desarrollaran su identidad y contribuyen a su desarrollo personal en el futuro. Por lo tanto, la literatura infantil es crucial para el desarrollo del lenguaje oral en los niños, ya que facilita su aprendizaje, mejora su capacidad para expresarse y comprender información, enriquece su vocabulario y fortalece su socialización en el entorno que se desenvuelve.
Dziecko milczące w kulturze i edukacji – analiza dyskursu filmowego
Authors: Wlazło Marcin
Published: September 2024

Sytuacja niemówienia (mutyzm, afonia, niemota, afazja) dotyczy zarówno identyfikowania biopsychicznych przyczyn tego stanu, jak i jego społeczno-kulturowych konsekwencji. O ile kwestie medyczne zaburzeń rozwoju językowego, a więc diagnoza i terapia neurologopedyczna nie budzą większych kontrowersji, o tyle społeczna, w tym szkolna obecność dziecka niemówiącego jest nadal zjawiskiem niepokojącym, obcym i niezrozumianym. Jak na każdy innym przypadek trudności (potrzeb) rozwojowych i edukacyjnych dziecka, na kwestię niemówienia można spojrzeć z perspektywy modelu medycznego (problemu zdrowotnego tkwiącego w dziecku) lub w kontekście modelu społecznego, a więc identyfikowania barier środowiskowych i społecznych utrudniających, ograniczających lub uniemożliwiających funkcjonowanie dziecka niemówiącego w roli ucznia. W artykule przedstawione zostały zależności między medycznym i społecznym podejściem do sytuacji szkolnej dziecka niemówiącego, ze szczególnym uwzględnieniem założeń edukacji włączającej. Wskazany został także kulturowy kontekst dziecka milczącego jako jednej z najpopularniejszych „protez narracyjnych” wykorzystywanych w literaturze i sztuce filmowej.
Szukając odpowiedzi – wirtualne społeczności na Facebooku jako forma współdzielenia się doświadczeniami rodziców dzieci z uszkodzonym słuchem
Authors: Skalny Magdalena
Published: September 2024

Prezentowany artykuł dotyczy charakterystyki grup FB stworzonych dla rodziców dzieci z uszkodzeniem słuchu. W części teoretycznej artykułu znajduje się opis, charakterystyka środowiska wirtualnego. Dokonano syntezy zagadnień związanych z wirtualną i tradycyjną komunikacją, wskazano różnice w korzystaniu z omawianych form porozumiewania się. Część teoretyczną kończy opis rodzicielstwa w kontekście wychowania dziecka z uszkodzeniem ze słuchem. Dokonano przeglądu badań z uwzględnieniem doświadczenia rodzicielstwa badanym kontekście. Część empiryczna dotyczy metodologii badań jaka posługują autorce do znalezienia odpowiedzi na pytania badawcze dotyczące opisu przykładowych wirtualnych grup przeznaczonych dla rodziców dzieci z uszkodzeniem słuchu. Pierwsze z nich dotyczy wybranych/przykładowych grup na FB, które są dostępne dla rodziców wychowujących dzieci z uszkodzeniem słuchu, opisu, które zagadnienia dominują w grupach rodziców z dziećmi z uszkodzeniem słuchu oraz w jakich obszarach rodzice z dziećmi z uszkodzeniem słuchu współdzielą się doświadczeniami poprzez wybrane grupy na FB. Odpowiedź na pytanie badawcze stanowi podstawę do tworzenia wniosków z przeprowadzonej analizy, ukazując wady i zalety grup FB dostępnych dla osób zainteresowanych zagadnieniami wychowania dzieci z uszkodzeniem słuchu. W artykule zaprezentowano wnioski płynące z analizy badań oraz implikacje dla nauki.
An overview of Centella asiatica and its therapeutic applications
Authors: Aszrin Farashakira Najiah , Adam Siti Hajar , Abdul Mutalib Maisarah , Tang Hooi Chia , Tang Shirley Gee Hoon
Published: September 2024

Globally, medicinal herb intervention has become popular in treating many illnesses. Centella asiatica (C. asiatica), a plant native to Southeast Asia, is utilized extensively due to its pharmacological and therapeutic benefits attributed by its triterpenoids and saponins. It has been widely researched for a variety of medicinal properties, including antidiabetic, antioxidant, wound healing, reproductive, sedative, anxiolytic, digestive, gastric ulcer, cognitive, antidepressant, and anti-inflammatory effects. The sedative qualities are associated with regulating the HPA axis to mitigate stress and modulate GABAergic activity, while its capacity to promote collagen production, provide antioxidant protection, and lower inflammation aids in the healing of wounds. Owing to a wide range of literature on C. asiatica, the significant discoveries about various diseases are occasionally overlooked. Hence, more concise and succinct information is warranted. This review aimed to summarize the potential medicinal aspects of C. asiatica, highlighting the medicinal properties, physicochemical properties and health benefits along with future direction of the therapeutic potential. While many of the well-established properties and effects have been proven, the procurement of further clinical trials must be attended to involving the determination of standardized procedures and investigate the ultimate possible function of C. asiatica in treating diverse medical diseases, thus, to fully comprehend the therapeutic benefits of the herb. By possessing numerous pharmacological properties, C. asiatica could potentially offer greater assistance in the medical world for treating the patients while minimizing risks and mitigating degenerative effects.
Kitap Tanıtım Değerlendirme-Tezkire-i Şu'arâ-yı Âmid
Authors: Kırık Halil İbrahim
Published: September 2024

Çalışmamızda, İdris Kadıoğlu tarafından 2014 yılında neşredilen ve müellifinin Ali Emîrî Efendi olduğu Tezkire-i Şu’arâ-yı Âmid adlı eserin tanıtım ve değerlendirmesiyle beraber kısa başlıklar maddeler halinde mevcuttur.
MİLLET KÜTÜPHANESİ ALİ EMÎRÎ MANZUM KOLEKSİYONU’NDAKİ TÜRKÇE DÎVÂNLARDA YER ALAN ALİ EMÎRÎ’YE AİT KUYÛDÂT
Authors: Aşı Havva , Güler Muhammed İkbâl
Published: September 2024

Yazma eserler, ana metni ve üzerine yazılan metin dışı kayıtlarıyla Osmanlı okuma kültürünü günümüze taşıyan önemli kaynaklardandır. Bu bağlamda yazma eserlerin içinde yer alan metinle birlikte üzerine yazılan metin dışı kayıtların da her birinin ayrı ayrı incelenmesi gerekir. Türkiye Yazma Eserler Kurumu Başkanlığı Yazma Eserler Veri Tabanı’nda Millet Kütüphanesinde kayıtlı toplam 86.416 eser mevcuttur. Bu eserlerin 370’i Ali Emîrî koleksiyonundaki Türkçe yazma dîvânlardan oluşmaktadır. Padişah ve şehzâde dîvânları, müellif hattı nüshalar ve doğrudan Ali Emîrî tarafından istinsâh edilmiş nüshaları da içinde barındıran bu koleksiyon, kuyûdât bakımından da zengin bir içeriğe sahiptir. Koleksiyonda temellük kaydı, istinsâh kaydı, fevâid kaydı, mübâyaa kaydı, mühür, manzume, dua ve tanımlanamayan birçok kayıtla birlikte doğrudan Ali Emîrî tarafından eklenmiş kayıtlar da tespit edilmiştir. Araştırma sürecinde Ali Emîrî Manzum Koleksiyonu Türkçe dîvânlardaki metin dışı bütün kayıtlar üzerine inceleme yapılmış; fakat bu çalışmada sadece Ali Emîrî tarafından yazma Türkçe dîvânların muhtelif sayfalarına eklenen kayıtlar değerlendirilmiştir. Kurduğu kütüphaneyle Türk dili, tarihi ve edebiyatına önemli hizmetler sunan Ali Emîrî, kütüphanesindeki kitaplara eklediği kayıtlarla da günümüze farklı alanlarda bilgi aktarmıştır. Çalışmada Ali Emîrî Manzum Koleksiyonu Türkçe Dîvânlar örneğiyle Osmanlı’nın son dönmelerinde okuma kültürünü ve bu kültürün bir yansıması olan metin dışı kayıtların içerik zenginliğini göstermek amaçlanmıştır.
THE CONTINUATION PLOT AS A MANIFESTATION OF SELF-REFLECTION IN MIKE NAUMENKO’S SONGS “SUBURBAN BLUES” AND “SUBURBAN BLUES NO. 2”
Authors:   Kazan (Volga region) Federal University, Stankovich Zinaida G.
Published: September 2024

The article is an analysis of literary self-reflection based on the material of M. Naumenko’s songs “Suburban Blues” and “Suburban Blues no. 2” which are considered as a mini-cycle, including the original plot and the continuation plot. Both texts are distinguished by a high degree of visualization which is made possible by Naumenko’s mention of a large number of subject details. Visualization attains a cinematic quality, which is reflected in the way of naming the above works in the cinematic prequel and sequel tradition. From the point of view of genre specificity, the first song can be called a philosophical and psychological drama, and the second – a melodrama. Those genres are in demand today primarily in cinema. The author of the article concludes that the change in genre originality from the first to the second text can be explained by connecting the mini-cycle with the third song, “Bitter Angel”, which enhances the drama of the other two works.
POETICS OF HISTORICAL MEMORY IN THE NOVELS OF S.A. ALEXIEVICH “LAST WITNESSES” AND “SECONDHAND TIME”
Authors:   Russian State University for the Humanities, Besova Arina V.
Published: September 2024

The article analyzes the functioning of memory in two novels by S.A. Alexievich, included in the cycle of books “Voices of Utopia” – “Last Witnesses” and “Secondhand Time”, which are based on the memories of witnesses of the Great Patriotic (Second World) War and the dissolution breakup of the USSR. The features of the poetics of memory in above novels are highlighted by analyzing the subjective organization of the text and the system of points of view, speech organization and figurative structure, as well as spatio-temporal organization, which allows talking about features of the poetics of historical memory in the novels by S.A. Alexievich and about features of the poetics of memory in a literary work as a whole. The influence of the novels on the remediation of the memory of the Great Patriotic War memory and the breakup of the USSR is considered
THE ROLE OF TRANSLATION STRATEGIES IN THE CONSTRUCTION OF A POETIC TEXT IN LANGUAGES WITH DIFFERENT STRUCTURES (“JANE EYRE” BY CH. BRONTE)
Authors:   The Federal State University of Education, Borodulina Ekaterina S.
Published: September 2024

The article provides a comparative analysis of the translations of poetic text in the framework of assessing the quality of the translation of the artwork. Stylistic deformations are considered for the first time, as well as their influence on the perception of the text. The role of domestication, foreignization and deformation in the construction of poetic text in different languages (Russian and French) is studied in detail. The author identifies reasons for the use of the above strategies and translation transformations as well as the most common translation techniques. He also considers the diachronic aspect of the use of deformation as a strategy in the construction of a poetic text.
ON THE ANIMAL TRAIL BOOK REVIEW: FEDUNINA O.V. KRIMINAL’NYI BESTIARII: ZVER’ – TEKST – ZHANR [CRIMINAL BESTIARY. BEAST - TEXT - GENRE]. TULA: AQUARIUS, 2023. 148 P
Authors:   Russian State University for the Humanities, Domanskii Yurii V.
Published: September 2024

The review considers the monograph “Criminal bestiary: beast – text – genre” by O.V. Fedunina, in which, through the prism of philological systematization and interpretation in a genre key, cases of the appearance in criminal literature of various hypostases and functions of representatives of the animal world are considered and comprehended.
Un balance historiográfico sobre las relaciones entre las Américas portuguesa y española en la América Meridional, 1808-1830
Authors: Castro Oscar Javier
Published: September 2024

Este artículo realiza un análisis de la historiografía multidisciplinar que ha estudiado las relaciones de los imperios ibéricos en la América meridional, desde diversas perspectivas. Se enfoca en el proceso revolucionario e independentista, el cual estaba en expansión en el mundo occidental y que, finalmente, desembocó en la disolución de tales imperios y la consecuente formación de nuevos Estados y naciones, entre 1808 y 1831.
The art of branding: an explorative pilot study into aspects of branding utilized by artisan entrepreneurs
Authors: Chandler Nick
Published: September 2024

Artisan and craft businesses have been and continue to be growing sectors. Branding plays a crucial role in the lives of artisan entrepreneurs and other entrepreneurs in the craft sector. With scant research into artisanal branding, this pilot study employs a theoretical framework to consider how artisan entrepreneurs build their brands. Pilot studies of qualitative research are recommended as a foundation for conducting a larger study, especially as a basis for developing contextual sensitivity. Five semi-structured interviews were conducted with artisan entrepreneurs in the UK. Initial findings indicate themes such as the use2 of storytelling, quality concerns, personal branding, the value of media and the importance of distribution stream in the branding. It is also found that there is a dilemma between pandering to customer tastes and following their own line of creativity. Based upon the findings, it is recommended to substantially increase sample size for such a heterogenous sample where each craft is seen as different from others.
How do the theatres in Budapest communicate their mission and values?
Authors: Komáromi György
Published: September 2024

This paper focuses on the communication strategies of theatres in relation to their missions and values. While it is widely accepted and encouraged in a general market context to explicitly communicate missions and values to both regular and potential customers, as well as all stakeholders, theatres in Budapest appear to differ in some aspects. Using sample data from the field to illustrate the concepts of the relevant literature conference paper tries to identify several factors explaining why theatres in Budapest almost never formulate written mission statements. This phenomenon can be explained by programming with well-defined branding, audience partition, sharing artistic resources (actors and creative personnel), and financing structure with public subsidies.
Informative genetic markers of predisposition to the formation of high-level intelligence
Authors: Mosse I. B. , Dokukina T. V. , Sedlyar N. G. , Mosse K. A. , Yanchuk E. P. , Glebko O. P. , Vankovich A. , Kilchevsky A. V.
Published: September 2024

This study is devoted to investigating the association of intelligence with a person’s genotype. Comparative psychological and molecular genetic testing was carried out on a representative sample of Belarusian population representatives numbering 746 people. Intelligence quotient (IQ) was determined using D. Wechsler’s test. It was established that the distribution of general intelligence values among the Belarusian population representatives was shifted towards higher results. The persons were divided into low and high IQ groups using the quartile method. The association of intelligence level with genotype was determined using a panel of genetic markers consisting of 18 gene polymorphic variants of neurogenesis, synaptic plasticity and neurotransmitter systems. Molecular genetic testing was carried out using real-time PCR. To automate a search for informative gene combinations associated with cognitive abilities, we used a special computer program that we had previously developed, taking into account the gene interaction effects. 15 most informative combinations of polymorphic gene variants associated with a high intelligence level were identified. These gene variants can be used to assess a genetic predisposition to the formation of high-level intelligence, which will allow assessing the abilities of candidates for extreme activities.
Genetic variability of the major birch pollen allergen Bet v 1 and characterization of B- and T-cell epitopes
Authors: Parkhomchuk O. Yu. , Fomina E. G. , Grigorieva E. E.
Published: September 2024

The hanging birch pollen collected in the period April – May 2020, 2021 in the territory of six regions of the Republic of Belarus was studied. Recombinant plasmid DNA was obtained. A nucleotide sequence of cloned fragments was determined. The results on the spectrum of isoforms of the Bet v 1 protein were analyzed. The obtained sequences corresponded to one degree or another to 11 genetic variants of the studied allergen. There were 7 isoforms of Bet v 1 defined within one tree. The predominant isoform of the birch pollen allergen Bet v 1 in the territory of the Republic of Belarus was Bet v 1.0101 (Bet v 1a, X15877.1). The identified variants were analyzed for their potential allergenicity by screening amino acids that according to the literature data were identified as affecting IgE-binding. The analysis of amino acid residues included in the IgE-binding conformational epitopes revealed amino acid substitutions exhibiting the multidirectional (high or low) IgE-binding activity in positions 31, 58, 113, 114, 126. The structure of dominant epitopes recognized by the T-cell receptor was studied. It was found that the C-terminal immunodominant T-cell epitope Bet v 1143–157 is highly conserved among various isoforms of the allergen in contrast to the epitope Bet v 178–93 located in the central region. The revealed amino acid substitutions of the studied sites can affect the activation of T-cells, cross-reactivity and significantly increase the variability of the expected IgE-mediated reaction.
Climatic and anthropogenic deflation change factors in the territory of Belarus and their regional features
Authors: Kukharik E. A. , Danilovich I. S. , Kostyuchenko I. V.
Published: September 2024

The present study deals with the analysis of the frequency and recurrence of extreme deflation phenomena in the territory of Belarus. The deflation intensity was estimated using meteorological data. 810 cases of dust storms and drifting snow were recorded in the country in the period of 1961–2022, of which 238 had low intensity, 213 – medium intensity and 359 – high intensity. The deflation phenomenon dynamics was analyzed: in the period of 1961–2000 the number of cases decreased gradually, but after 2000 there was an increase in dust storms. The growth of deflation repeatability corresponds to ongoing current climate changes. The spatial zoning of the country by deflation intensity was conducted based on the relief, the composition and structure of cover deposits, and the conditions of economic development of the area. The zones are presented as follows: with low deflation intensity (central Belarusian hills and ridges, northern and eastern regions of the country), medium (central regions of the country) and high (Belarusian Polesie, Grodno, Volkovysk and Slonim uplands with adjacent plains and lowlands).
New fibrous carboxyl cation exchangers for sorption cations of heavy and non-ferrous metals from water
Authors: Pryhazhayeva L. M. , Medyak G. V. , Shunkevich A. A. , Polikaгpov A. P. , Ogorodnikov V. A.
Published: September 2024

New fibrous carboxyl cation exchangers FIBAN were synthesized by the method of graft copolymerization to polypropylene staple fibers of acrylic acid and various bifunctional comonomers (divinylbenzene – DVB, ethyleneglycoldimethacrylate – EGDM, methylene-bis-acrylamide – MBAA). Sorption properties of the fibers towards cations of heavy and non-ferrous metals (Cо2+, Ni2+, Zn2+, Cd2+, Cu2+ и Pb2+) were studied on the model solutions in the dynamic regime. The dynamic activity of the crosslinked sorbents towards Cu2+ and Pb2+ ions is higher compared to fibrous analogues FIBAN Х-1, FIBAN Х-2, FIBAN К-6М, FIBAN К-5, VION КN-1. The best sorbent for lead ions between the crosslinked fibers is the fiber with EGDM. The fiber with MBAA has a higher affinity towards the cations of Ni2+, Zn2+, Cd2+ and Cа2+, which increases with the increasing of the degree of crosslinking by MBAA. Studying the fibers by the methods of Fourier-transform IR-spectroscopy, scanning electron microscopy, analyzing of the chemical oxygen demand in water extracts and determination of the equivalent moisture capacity coefficient coefficient demonstrated that the crosslinking by MBAA provides a stable structure of the sorbent. The high stability of the crosslinked structure combined with the high ion exchange capacity near 7 mEq/g and dynamic activity towards the cations of Pb2+, Zn2+, Cd2+ и Cа2+ makes the fibrous carboxyl sorbent with MBAA safe and perspective for drinking water purification.
Ligand-binding characteristics of CYP51 Mycobacterium tuberculosis in relation to marine steroid compounds
Authors: Karputs A. I. , Kapustina I. I. , Tabakmakher K. M. , Makarieva T. N. , Kicha A. A. , Ivanchina N. V. , Dmitrenok P. S. , Kaluzhskiy L. A. , Gilep A. A.
Published: September 2024

CYP51 steroid-14α-demethylases are members of a large superfamily of cytochrome P450 enzymes found in all kingdoms of living organisms, and catalyze the 14α-demethylation reaction of a number of natural steroids, including lanosterol, obtusifoliol, and 24,25-dihydrolanosterol. CYP51 are important components of the eukaryotic steroid biosynthetic chain, and thus represent one of the main targets for antifungal therapy. A 14α-demethylase CYP51 homologous gene has also been found in the genome of Mycobacterium tuberculosis. At the same time, M. tuberculosis lacks the de novo pathway for steroid biosynthesis. Conservation of CYP51 among the Mycobacterium genus and colocalization in the genome with 3Fe-4S ferredoxin Rv0763c, which maintains its catalytic activity in vitro, may indirectly indicate the involvement of MTCYP51 in a biochemical process important for mycobacteria. In order to characterize the specificity of the MTCYP51 active site to various compounds of isoprenoid nature, we obtained a highly purified MTCYP51 and, using spectrophotometric titration and surface plasmon resonance methods, studied the interaction of MTCYP51 with steroids from marine organisms obtained in the Pacific Institute of Bioorganic Chemistry of the Far Eastern Branch of the Russian Academy of Sciences. The investigated compounds represent a wide range of evolutionarily ancient isoprenoids. The results showed that MTCYP51 is able to bind structurally diverse steroid derivatives in the active site. The conducted studies suggest the biological role of MTCYP51 for pathogenic mycobacteria, which consists in the binding and possible metabolism of exogenous bioregulatory isoprenoids in vivo.
PREPARATION AND STANDARDIZATION OF EXPERIMENTAL BATCHES OF "PHOTORAN E6, LYOPHILIZATE FOR THE PREPARATION OF SOLUTION FOR INFUSIONS", A DRUG FOR PHOTODYNAMIC THERAPY USING HOGWEED LEAVES AS RAW MATERIALS
Authors: Pogartseva Yu. A. , Kauhova I.E.
Published: September 2024

Introduction. In recent years, there has been a sharp increase in the number of oncological diseases associated with more frequent detection of malignant neoplasms, including in the early stages. Photosensitizers are widely used for the diagnosis and treatment of oncological diseases. Already at the beginning of the twentieth century, it was discovered that a cancer cell is able to accumulate and retain colored substances [1]. In Russia, the photosensitizer "Photoran E6, lyophilizate for the preparation of an infusion solution" is widely used for the diagnosis of malignant tumors. The sub-stance for its production is sodium chloride E6, obtained by chemical synthesis from methylpheophorbide A. which, according to the patent, is extract-ed from the biomass of the green microalgae Spirulina Platensis, native to Japan and California. In this regard, there is an urgent question of replacing imported intermediates with more affordable ones. For this purpose, Sosnowski's hogweed (Heraculum sosnowskyi) was chosen. In connection with the above, the aim of this study was to obtain and standardize in terms of quality the finished drug for photodynamic therapy "Pho-toran E6, lyophilizate for the preparation of an infusion solution" produced from sodium chloride E6, synthesized using a new type of raw material (leaves of borscht Sosnowski). Material and methods. The object of the study was three series of the finished medicine product (hereinafter referred to as GLS) "Photoran, lyophi-lizate for the preparation of an infusion solution", produced from an active pharmaceutical substance synthesized from methylpheophorbide a, ob-tained, in turn, from the leaves of borscht Sosnovsky as an alternative source of vegetable raw materials [2]. The quality indicators of the finished me-dicinal product were determined according to the methods described in the regulatory documentation in accordance with the Regulatory Documentation of the XIV and XV editions. Results. For the research, the aseptic production of three series of GLS was carried out from the previously produced active pharmaceutical sub-stance Sodium Chloride E6. AFS was synthesized from an intermediate obtained from the leaves of borscht Sosnowski. The standardization of the ob-tained series of the drug has been carried out. The possibility of using Sosnowski's hogweed as a plant raw material for the production of photosensi-tizers based on chlorophyll derivatives has been evaluated. Conclusion. In the course of the study, the technology of aseptic production of GLS "Photoran, lyophilizate for the preparation of solution for infusions" was implemented. The quality indicators of the three produced batches of the finished drug have been determined.
PLATELET ACTIVATION IN THE PROGNOSIS OF CARDIOVASCULAR RISKS IN PATIENTS WITH PSORIASIS
Authors: Shelamova D.A. , Gaikovaya L.B.
Published: September 2024

Psoriasis is a chronic inflammatory immune-dependent genodermatosis, mainly affecting the skin, with a prevalence in the population from 1 to 5%. The pathogenesis of psoriasis is based on Th1-dependent autoimmune inflammation, which leads to a change in the aggregation properties of platelets, increased excretion of thromboxane-A2, which worsens microcirculation processes and causes the development of endothelial dysfunction. Psoriasis is associated with a number of concomitant nosologies, such as psoriatic arthritis, depression, inflammatory bowel disease and cardiometabolic syndrome. Platelets play an important role in the development of cardiovascular diseases, as mediators of hemostasis. However, the number of publications on their pathophysiological contribution to the development of cardiovascular risks in patients with psoriasis is insignificant. Understanding the role of platelet activation in psoriasis and the correct choice of laboratory methods for their assessment will allow the timely prevention of vascular platelet disorders and prognosis.
MINERAL PHYSICS ANALYSIS OF ALLUVIAL ROCKS AS A SOURCE OF SHALLOW HYDROCARBON SEEPAGE IN BELIS VILLAGE, WARU BASIN, EASTERN SERAM ISLAND, MALUKU PROVINCE
Authors: Sapulete Sisca M. , Nukuhaly Manda S. , Souisa Matheus
Published: September 2024

Belis Village is located in the Waru basin adjacent to the Bula basin on the eastern part of Seram Island and has potential shallow hydrocarbon manifestations. This research aims to determine the mineralogical characteristics of the rocks that make up shallow hydrocarbon manifestations at the research location. The research method used is physical analysis of minerals including petrographic analysis and XRD methods. The analysis results of the XRD method show an abundance of quartz minerals at 58%, followed by clay minerals at 35%, opaque minerals at 25%, and the rest in the form of cavities while feldspar minerals are secondary minerals. The results of the XRD analysis show that the more dominant mineral is protoenstatite (MgSio3) with an average abundance of 70.33% as a carrier of shallow hydrocarbon seeps, Quartz (SiO2) with an average abundance of 18.46%, and Clinoestatite with an average abundance of 11.21% as a mineral associated with shallow hydrocarbon seeps.
Efficiency of Supply Chain Management Performance in Potato Farming with Data Envelopment Analysis
Authors: Putri Dindy Darmawati , Fadlillah Nurfahmi , Suyono Suyono , Wijayanti Irene Kartika
Published: September 2024

The potato farmers in Karangreja District use two supply chain channels, namely the supply chain channel partnership non-partnership supply chain channels. The existence of a good supply chain channel, will provide benefits and benefits that are evenly distributed to all parties involved in distributing potato products to consumers. The purpose of this research is to analyze the differences in profit, farmer share, and supply chain efficiency in partnership and non-partnership patterns in Karangreja District, Purbalingga Regency. The farmer sampling method using Simple Random Sampling obtained 500 partnership pattern farmers and non-partnership pattern farmers. Determination of marketing agencies using the Snowball Sampling technique obtained collectors, wholesaler, and retailers. Analysis of the data used is the analysis of supply chain efficiency and analysis of different tests. The results of the analysis show the supply chain efficiency analysis shows that 42.86 farmers operating efficiently have partnership patterns and 57.20 non-partner pattern farmers. The different test analysis shows that for profit and farmer's share indicators there is a significant difference between the partnership pattern and the non-partnership pattern. As for the marketing margin indicators and performance efficiency, there is no significant difference between the partnership pattern and the non-partnership pattern
STEM-PjBL Learning Model To Enhance Critical Thinking Skills of Students on Magnets, Electricity, and Technology
Authors: Lestari Hasanah Dewi , Rahmawati Yuli , Usman Herlina
Published: September 2024

This study aims to enhance the critical thinking skills of fifth grade elementary school students on topics of magnet, electricity, and technology through the STEM-PjBL model. The study involved 20 students. The research design employed was classroom action research conducted in three cycles. Qualitative data analysis techniques were utilized. The analysis of students' critical thinking skills focused on five indicators: Identify Question at Issue, conceptual understanding, ideas connection, assumptions, and inferences, with five levels of achievement. The results showed an improvement in critical thinking skills, with 75% of students' responses at a very good level of critical thinking, 35% at the mastering level in cycles I and II, and 45% in cycle III, along with 35% at the competent level. Meanwhile, those at the developing level were 15% in cycles I and II, increasing to 20% in cycle III. The remainder was 5% at the emerging stage in cycle I and 10% in cycle II. There were 5% at the absent level in cycle I. Therefore, the STEM-PjBL model can be considered an effective approach for students to enhance their critical thinking skills in IPAS learning and to support their active engagement in the classroom.
Skrifter utgivna av Svenska institutet i Athen, 8°
Authors:   Stockholm University, Habetzeder Julia
Published: September 2024

Also known as Acta Instituti Atheniensis Regni Sueciae, series in 8˚ (ISSN 0081-9921), this series was first published in 1951 and is the smaller of the two Acta series. It includes monographs and collections of scholarly works such as conference volumes within the fields of Classical Archaeology, Ancient History and Greek Philology. The bibliographical abbreviation is ActaAth-8˚.
The Tomba Åström and the 1969 excavations at San Giovenale
Authors: D'Acri Mattia , Tobin-Dodd Fredrik
Published: September 2024

In June 1969, Paul Åström and a group of students from the Swedish Institute of Classical Studies in Rome conducted a small series of excavations at San Giovenale, an Etruscan site in the inland between Cerveteri and Tarquinia. The material was unpublished until now, but a study of the finds and archival material suggests that it primarily comes from a chamber tomb constructed in the second half of the 7th century BC, in the late Orientalizing period, and probably used for several burials.
The development of the water supply on the Peloponnese in Greco-Roman times
Authors: Klingborg Patrik
Published: September 2024

It has long been clear that the water supply in ancient Greece was transformed over time, with the relative number of various types of water sources varying in time and space. Yet, what patterns this produced has never been explored, and the degree to which trends suggested by local or qualitative studies are representative for larger areas and patterns is unknown. The root of this uncertainty lies largely in the difficulty assembling an extensive and representative material beyond individual sites or cities. Following this, the present article has two aims. The first is to test and evaluate a method for collecting an extensive and (more) representative material for the investigation of the water supply in ancient Greece on a regional scale, based on a systematic review of the material from the Peloponnese published in Archaeological Reports 1887–2012. The second aim is to discuss how the collected data can be used to explore the transformations of the water supply systems on the Peloponnese in the period 900 BC–AD 300. Together the results are intended to develop further the WaterWorks project, which aims to create a better understanding of the development of the ancient water supply. The method produced a considerably better dataset than previously available. The dataset, recorded in an Access database, suggests that some hitherto acknowledged trends are probably valid for larger areas while others are less prominent than previously believed. However, in the end, the dataset is too limited to allow firm conclusions concerning how, and to a larger degree why, the water supply system was transformed over time. The dataset will be made publicly accessible in an open access repository.