bluuebunny/crossref_metadata_2025 huggingface dataset:
Ultrastructural Analysis of Inflammatory Breast Cancer Cell Clusters in an Ex Vivo Environment Mechanically Mimicking the Lymph Vascular System
Authors: Fujii Yuka , Krishnamurthy Savitri , El-Zein Randa
Published: December 2021

Background:

Inflammatory breast cancer (IBC) is a rare form of breast cancer with a poor prognosis. IBC is characterized by florid lymphovascular tumor emboli in the skin and the parenchyma of the breast. We hypothesized that the formation of these emboli/clusters plays a pivotal role in IBC metastasis and its rapid progression, and that their structure and function may be a key to identifying molecular biological differences between IBC and non IBC.

Methods:

Mechanical methods were used to mimic the lymph fluid viscosity by adding 2.25% of PEG8000 to the media. Clusters were obtained for IBC tumor cell lines (SUM149 and IBC-3), non IBC tumor cell lines (MDA-MB-231, MDA-MB-468, and MCF7), and a non-tumorigenic human mammary epithelial cell line (MCF10A). Clusters were analyzed by light microscopy, and then prepared for and observed by transmission electron microscopy (TEM).

Results:

Significant differences were seen between IBC and non IBC clusters. The TEM analysis revealed that IBC cells harbored numerous microvilli and microvesicles, both on the free outer surface and inside the cluster. Microvilli from IBC cell clusters were noted at higher density and were longer than those of non IBC cell clusters.

Conclusions:

IBC tumor cell clusters exhibited distinct ultrastructural features characterized by the presence of long, crowded microvilli and numerous microvesicles. These microvilli may play an important role in the biology and aggressiveness of IBC.
Development of the South Sudan Mental Health Assessment Scale
Authors: Ng Lauren C. , Solomon Jordan S. , Ameresekere Maithri , Bass Judith , Henderson David C. , Chakravarty Shubha
Published: December 2021

This study developed and validated a measure that captures variation in common local idioms of distress and mental health problems experienced by women in South Sudan, a country which has experienced over 50 years of violence, displacement, and political, social, and economic insecurity. This measure was developed during a randomized controlled trial of the Adolescent Girls Initiative (AGI) and used qualitative Free Listing (n = 102) and Key Informant interviews (n = 27). Internal reliability and convergent validity were assessed using data from 3,137 randomly selected women (ages 14–47) in 100 communities in South Sudan. Test-retest and inter-rater reliability were assessed using responses from 180 women (ages 15–58) who completed the measure once, and 129 of whom repeated the measure an average of 12 days (SD = 8.3) later. Concurrent validity was assessed through the ratings of 22 AGI leaders about the presence or absence of mental health symptoms in the 180 women in the test-retest sample. The study resulted in the development of the South Sudan Mental Health Assessment Scale, a 24-item measure assessing six idioms of distress. The scale consisted of one factor and had excellent internal, test-retest, and interrater reliability. The scale also demonstrated good convergent and concurrent validity and performed well psychometrically. Moreover, its development provides an example for other organizations, working in environments where mental health measures have not yet been developed and validated, to create and validate measures relevant to their populations. In this way, the role of mental health in development settings can be more rapidly assessed.
Magnetorheological Elastomer based torsional vibration isolator for application in a prototype drilling shaft
Authors: Syam Thaer M. I. , Muthalif Asan G. A.
Published: December 2021

Smart materials properties are altered using external stimuli such as temperature, pressure and magnetic field. Magnetorheological Elastomer (MRE) is a type of smart composite material consisting of a polymer matrix embedded with ferromagnetic particles. In the presence of an external magnetic field, its mechanical properties, such as stiffness, change due to the interaction between the magnetic particles, which have applications in vibration isolation. Unwanted vibration in machines can cause severe damage and machine breakdown. In this work, a semi-active vibration isolator using MRE is proposed for a potential application in a drilling system to isolate the torsional vibration. The MRE was fabricated with a 35% mass fraction (MF) consisted of silicon rubber and iron particles. It was fitted with aluminium couplers and attached to the shaft (drill string) to study its efficiency in vibration isolation under a magnetic field. Two tests were conducted on the drilling prototype setup used in this work; the first test was a hammer impact test. The torsional transfer function TTF analysis showed that the system’s natural frequency has shifted from 13.9 Hz to 17.5 Hz by the influence of increasing magnetic field around the MRE. The results showed that the continuous rotational vibration amplitude of the prototype is attenuated by more than 40%.
How the interplay between organisational ‘culture’ and ‘climate’ shapes police officers’ perceptions of community policing
Authors: Fenn Liam , Bullock Karen
Published: December 2021

This article draws on interview data and the concepts of organisational ‘culture’ and ‘climate’ to critically assess police officers’ perceptions of community policing in one English constabulary. In so doing, it considers the cultural, organisational and wider contextual determinants of officers’ alignment to this style of police work. With an emphasis on developing community partnerships and engaging in problem-solving, rather than enforcement of the criminal law, community policing has been seen a primary way of rendering officers more ‘responsive’ to the needs of citizens, improving police–community relations and driving down crime rates. An important reform movement in police organisations around the world, the success of community policing nonetheless depends on officers’ willingness and ability to deliver it. Accordingly, the generation of evidence about the ‘drivers’ of officers’ attitudes to inform strategies to promote the delivery of the approach is essential. Findings suggest that officers value community policing as an organisational strategy but that the approach maintains a low status and is undervalued compared with other specialisms within the organisation. This is born of an organisational culture that foregrounds law enforcement as the primary function of police work and an organisational climate that reinforces it. This has implications for community officers in terms of their perceptions of and attitudes towards the approach, self-esteem and sense of value and worth, perceptions of organisational justice, discretionary effort and role commitment. Recommendations for police managers are set out.
The Square Inch quilting studio: Survival strategies for a lifestyle enterprise
Authors: Krishnan S Navaneetha , Ganesh L S , Rajendran C
Published: December 2021

This case focuses on how a lifestyle enterprise has used strategies to survive amidst the COVID-19 crisis. It explores how a lifestyle enterprise, ‘The Square Inch’, a quilting studio, (a) conducts teaching workshops, (b) stitches and sells quilts and (c) sells raw materials and accessories, including sewing machines required for quilting. The case provides a detailed account of the risks, uncertainties and crises faced by a lifestyle enterprise and its entrepreneur during its founding and growth. This case also highlights how resilience, entrepreneurial orientation and innovation can be used as survival strategies to overcome challenges. The case engages students to understand the survival strategies employed by a lifestyle entrepreneur in times of crisis.
Becoming interested—the evolvement of research interest in case study research on sports
Authors: Andersson Åsa , Korp Peter , Reinertsen Anne B
Published: December 2021

This article challenge research political assumptions of research interests as context specific phenomena predefined by researchers and others in case study research on sports. By adopting a Deleuzian perspective of materiality, the aim is to overturn academic power dimensions as well as anthropocentric focuses and instead explore how research interests emerge in case-assemblages. This is a radical shift that re-theorizes the production of research interests as co-produced capacities in researching bodies. The analysis is done by mapping territorializing, deterritorializing, and reterritorializing affects as well as molar and molecular affects. We use these affects to explore how our research interest evolved in a case study on a swimming event. We conclude by extending this critical exploration to the production of research interests in general and the exaggerated belief that research interests are attributes of specific human bodies (researchers) that precede studies.
Is architecture relevant for political theory?
Authors: van Leeuwen Bart
Published: December 2021

Is architecture relevant for political theory? That is the key question that structures this excellent collection Political Theory and Architecture, although a number of essays fit a broader formulated theme better, namely, concerning the political relevance of the organization and design of our built environment more generally, including architecture but also spatial planning and urban design. The collection demonstrates that our build environment is not merely a passive backdrop to a political community, but actively shapes aspects of our common political life. This constitutive nature of our built environment figures in many different guises throughout this volume. In this review article, I discuss some of these and conclude that concerns about the ‘common good’ and hence about the discipline of political theory should take reflections on urban design, planning, and architecture into account.
Sovereignty, territory, and the legitimacy of the international order
Authors: Murphy Colleen
Published: December 2021

In The Shifting Border, Ayelet Shachar (2020) argues that the exercise of sovereign power through border regimes no longer tracks territorial boundaries. In my commentary, I first argue that Shachar’s analysis implicitly calls into question the legitimacy of the international order. I then raise the worry that the logic which severs the link between the exercise of sovereignty and territory is the same logic that can be used to justify injustice and atrocity such as ethnic cleansing. Shachar’s normative proposals do not sufficiently recognize or guard against this risk.
Climate Change and the Politics of Apocalyptic Redirection
Authors: Cross Ben
Published: December 2021

Alison McQueen’s study of the historical role of apocalyptic ideas in realist political theory cautiously proposes the ‘redirection’ of apocalyptic thought as a plausible alternative to its rejection. Apocalyptic redirection, so understood, uses apocalyptic language to describe potential future catastrophes in order to inspire drastic action to prevent them. Although McQueen acknowledges that apocalyptic redirection may have certain risks, she suggests it may be an appropriate response to the crisis of climate change. In this article, I aim to show that this use of the discourse of apocalyptic redirection is ideologically problematic. I argue that it involves conflating the interests of those who are at least moderately materially comfortable with the interests of humanity as a whole. I will also draw on the 2019 ‘Stop Adani Convoy’ in Australia as a case study to show how the ideological character of this discourse renders it ill-suited to generating popular support for action on climate change, and liable to reproduce existing power relations.
Passing Extracranial Artery Occlusion by Intermediate Catheter With Expanding Microballoon (PEACE): A Novel Endovascular Therapy in Acute Tandem Occlusion Stroke
Authors: Cheng Zhe , Rajah Gary B. , Gao Jie , Geng Xiaokun , Ding Yuchuan
Published: December 2021

Purpose:

Endovascular treatment of atherosclerotic tandem occlusions in acute ischemic stroke (AIS) is a matter of debate. This article reports a single-center experience using an intermediate catheter with microballoon for treatment of tandem occlusions.

Methods:

A total of 151 AIS patients with large vessel occlusion received endovascular therapy and a consecutive series of patients (n = 26) who suffered from tandem cervical intracranial occlusions were treated using the Passing Extracranial Artery Occlusion by Intermediate Catheter with Expanding Microballoon (PEACE) technique. Intracranial recanalization was achieved by aspiration or stent retriever and then emergency stenting was performed for extracranial internal carotid artery (ICA) lesion. Demographic, clinical characteristics, procedural details of endovascular therapy, and prognosis outcome were assessed. The outcomes of tandem occlusion group were compared with isolated intracranial occlusion group (n = 122) and previous studies.

Results:

As compared to isolated intracranial occlusion groups, only a few patients suffered from atrial fibrillation (7.7% vs 38.5%, p<0.01) in tandem occlusions group. A larger proportion of patients (61.5% vs 29.5%) had tandem occlusions in which extracranial ICA occlusion was combined with intracranial terminus occlusion in ICA (p<0.01). 46.2% of tandem occlusions patients achieved intracranial recanalization by aspiration alone versus 15.6% in patients with isolated intracranial occlusion (p<0.01). In tandem occlusion patients treated with PEACE, 92.3% achieved successful reperfusion (thrombolysis in cerebral infarct [TICI] ≥2b). The median time from puncture to recanalization was 51 minutes (interquartile range [IQR], 41–66). 67.6% favorable functional prognosis (modified Rankin score [mRS], 0–2) was seen, with 11.5% mortality and 3.8% of symptomatic intracerebral hemorrhage (sICH) at 90 days. These outcomes are all consistent or better than previously reported studies performed for tandem occlusion.

Conclusions:

Endovascular therapy using the PEACE technique with intermediate catheter and lined expanding microballoon is safe, efficient, and fast in the treatment of atherosclerotic tandem occlusion patients.
Providers and Families Weigh in on Delays to Pediatric Kidney Transplant Wait-List Activation
Authors: Farkas-Skiles Cristina M. , Feinsinger Ashley , Pines Rachyl , Waterman Amy D.
Published: December 2021

Introduction

Timely access to kidney transplant is essential to reducing mortality of children with kidney disease. We examined factors affecting providers’ decisions to delay waitlisting, compared perceptions of important factors of providers to families, when delaying activation, and describe recommendations to improve support for pediatric patients and families to overcome waitlisting delays.

Methods

Using a mixed-methods design, 20 providers and 20 families of pediatric patients with kidney disease, participated in interviews and surveys. Interviews were analyzed using thematic analysis. Surveys were analyzed with descriptive statistics.

Results

Avoiding retransplantation, treatment nonadherence, poor psychological readiness for transplant, poor physical health, and greater need for social support were the key themes affecting providers’ decisions to delay waitlisting. At least 70% of both providers and families felt that waitlisting should be delayed until patients and families had reliable access to transportation, mental health support, and caregivers who can better understand medical information. At least 70% of families surveyed felt it was important to delay waitlisting until they had regulated blood pressure and well-managed labs. Ethical concerns emerge that waitlisting practices may contribute to disparities in access to transplant.

Conclusion

Providers and families agree that stabilizing the family situation and improving adherence to treatment are important reasons to delay waitlisting. However, pediatric patients facing greater disparities need easier access to psychological services, strengthened social support, access to economic resources, and stronger relationships with coordinators. Addressing patient burdens is essential for reaching more equitable listing practices.
Hypofractionated Simultaneous Integrated Boost Radiotherapy Versus Conventional Fractionation Radiotherapy of Early Breast Cancer After Breast-Conserving Surgery: Clinical Observation and Analysis
Authors: Dong Jinling , Yang Ya , Han Dan , Zhao Qian , Liu Chengxin , Sun Hongfu , Wang Zhongtang , Lin Haiqun , Huang Wei
Published: December 2021

Purpose: The objective of this retrospective study is to evaluate the efficacy and safety of hypofractionated simultaneous integrated boost radiotherapy for early breast cancer patients undergoing breast-conserving surgery. Methods: A total of 185 women with early breast cancer undergoing breast-conserving surgery were retrospectively divided into hypofractionated simultaneous integrated boost group and conventional fractionation group. Hypofractionated simultaneous integrated boost included 104 patients and the dose of whole-breast radiation reached 42.56 Gy in 16 fractions and simultaneously tumor bed boost to 48 Gy in 16 fractions, which course of radiotherapy was 22 days. The 81 patients of the conventional fractionation group received whole breast radiation to 50 Gy in 25 fractions and followed by tumor bed boost to 10 Gy in 5 fractions, which course of radiotherapy was 40 days. Clinical information including patients’ characteristics, skin toxicity, myelosuppression, radiation pneumonia, and cosmetic effects was recorded to analyze the influence of age, chemotherapy, position, and breast volume on the results of radiotherapy. Results: Hypofractionated simultaneous integrated boost group had no case of recurrence after a median follow-up of 25.6 months (9-47 months)) as compared with 2 after a median follow-up of 33.4 months (25-45 months) in the conventional fractionation group. The 2 groups had similar results in skin toxicity, cosmetic outcomes, and radiation pneumonia. In terms of myelosuppression, grade 1, grade 2, and grade 3 of myelosuppression in the hypofractionated simultaneous integrated boost group accounted for 16.7%, 12.3%, and 3.5% as compared with 30.0%, 21.1%, and 12.3% of the conventional fractionation group, respectively ( P = .000). Conclusions: HF-SIB RT is a considerable option in patients after breast-conserving surgery with a lower degree of myelosuppression and shorter treatment time.
High Expression of VAV Gene Family Predicts Poor Prognosis of Acute Myeloid Leukemia
Authors: Mu Dan , Long Sili , Guo Ling , Liu Wenjun
Published: December 2021

Objectives: VAV family genes ( VAV1, VAV2, and VAV3) are associated with prognosis in various cancers; however, they have not been evaluated in acute myeloid leukemia (AML). In this study, the prognostic value of VAV expression in AML was evaluated by a single-center study in combination with bioinformatics analyses. Methods: The expression and prognostic value of VAVs in patients with AML were investigated using various databases, including GEPIA, CCLE, EMBL-EBI, UALCAN, cBioPortal, STRING, and DAVID. Blood samples from 35 patients with AML (non-M3 subtype) and 13 benigh individuals were collected at our center. VAV expression levels were detected by real-time quantitative PCR (RT-qPCR) and western blotting. Clinical data were derived from medical records. Results: Based on data from multiple databases, the expression levels of VAV1, VAV2, and VAV3 were significantly higher in AML than in control tissues ( P < 0.05). RT-qPCR and western blotting results showed that VAV expression in mRNA and protein levels were higher in patients with AML that in the control group ( P < 0.05). Complete remission rates were lower and risks were higher in patients with AML with high VAV1 expression than with low VAV1 expression ( P < 0.05). High levels of VAV2, VAV3, and VAV1 were related to a poor overall survival, and this relationship was significant for VAV1 ( P < 0.05). High expression levels of genes correlated with VAV1, such as SIPA1, SH2D3C, and HMHA1 were also related to a poor prognosis in AML. Functional and pathways enrichment analyses indicated that the contribution of the VAV family to AML may be mediated by the NF-κB, cAMP, and other pathways. Conclusion: VAVs were highly expressed in AML. In particular, VAV1 has prognostic value and is a promising therapeutic target for AML.
Editors’ Introduction to the Special Issue of the Journal of Transformative Education on Assessing Transformative Learning
Authors: Acheson Kris , Dirkx John M.
Published: December 2021

Over 40 years ago, Jack Mezirow introduced the idea of transformative learning (TL) to the adult education community. Representing a profound shift in how one thinks and feels about one’s self and the socio-cultural context in which one is embedded, transformative learning has since evolved to reflect numerous theoretical lenses and its framework continues to be extended and elaborated. As TL theory expands within different contexts and across different disciplines, particularly within postsecondary education, the term transformative learning is often employed with scant connection to the theoretical framework in which it was initially grounded. Learners and educators alike frequently describe learning experiences as transformative, yet little consensus exists around a definition of transformative leaning However, if the field is to continue to evolve theoretically, we cannot accept these claims of transformation at face value. The phenomenon must be measured in some manner. The field continues to struggle with several perennial issues related to assessment. This special issue of the Journal of Transformative Education seeks to address the need to wrestle with these underlying theoretical and conceptual issues by critiquing the state of the field, introducing new approaches to operationalizing the phenomenon, and advancing new trajectories for research. We approach this charge through two major threads explored through eight papers that represent Methodological Innovations and Cases of Methodological Application. We close this introduction to the Special Issue with key themes represented in the eight papers and recommendations for addressing the challenges of assessing the processes and outcomes of transformative learning.
Preclinical Evidence for the Mechanisms of Transcranial Direct Current Stimulation in the Treatment of Psychiatric Disorders; A Systematic Review
Authors: Yamada Yuji , Sumiyoshi Tomiki
Published: December 2021

Backgrounds. Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique for the treatment of several psychiatric disorders, eg, mood disorders and schizophrenia. Although tDCS provides a promising approach, its neurobiological mechanisms remain to be explored. Objectives. To provide a systematic review of animal studies, and consider how tDCS ameliorates psychiatric conditions. Methods. A literature search was conducted on English articles identified by PubMed. We defined the inclusion criteria as follows: (1) articles published from the original data; (2) experimental studies in animals; (3) studies delivering direct current transcranially, ie, positioning electrodes onto the skull. Results. 138 papers met the inclusion criteria. 62 papers deal with model animals without any dysfunctions, followed by 52 papers for neurological disorder models, and 12 for psychiatric disorder models. The most studied category of functional areas is neurocognition, followed by motor functions and pain. These studies overall suggest the role for the late long-term potentiation (LTP) via anodal stimulation in the therapeutic effects of tDCS. Conclusions. tDCS Anodal stimulation may provide a novel therapeutic strategy to particularly enhance neurocognition in psychiatric disorders. Its mechanisms are likely to involve facilitation of the late LTP.
Smart contract-based secure cooperative spectrum sensing algorithm
Authors: Ji Chu , Zhu Qi
Published: December 2021

Spectrum sensing is the key technology of cognitive radio. In this article, we apply blockchain technology in spectrum sensing process and propose a related algorithm based on reputation. The algorithm builds a system model based on smart contract in blockchain and applies blockchain asymmetric encryption algorithm and digital signature technology in the process of secondary users’ transmitting local judgments to the secondary user base station. The algorithm can resist spectrum sensing data falsification (SSDF) attack launched by malicious users. This article comprehensively considers the channel error rate, detection probability, secondary user base station budget and remaining energy of the secondary users (SUs) and then establishes the SU’s utility function as well as the game model. By solving the Nash equilibrium, the SU determines whether it uploads sensing data. Finally, the SU base station selects registered SUs by calculating and updating their reputation, obtaining the final judgment by voting rule. With simulations, we prove that the algorithm proposed in this article increases the accuracy and security of spectrum sensing and can effectively resist SSDF attack.
Factors associated with in-stent stenosis after cerebral aneurysm embolization using a Pipeline embolization device
Authors: Flores-Milan Gabriel , Pressman Elliot , Peto Ivo , Ren Zeguang , Guerrero Waldo R. , Mokin Maxim
Published: December 2021

Background

Flow-diverting (FD) stents, with or without coiling, are a mainstay in endovascular treatment of intracranial aneurysms (IAs). One observed complication from flow diverter stent (FDS) insertion has been in-stent stenosis. Though previously studied in the short-term period, the long-term history of this complication has yet to be described.

Methods

We performed a retrospective cohort study of consecutive IAs treated with Pipeline Embolization Device (PED), with or without coiling, at our centre between September 2014 and December 2018 that had at least one digital subtraction angiogram (DSA) during follow-up. In-stent stenosis was measured from DSA images, and associated patient and procedural characteristics were analysed.

Results

94 patients treated with PED for IA were identified. On initial DSA during follow-up, 52 patients (55.3%) had in-stent stenosis within the PED. Of these 52 patients, 17 had a second DSA during follow-up. In this 2nd DSA, improvement and/or stable in-stent stenosis was seen 16 patients (94.1%). One patient in this group had worsening in-stent stenosis had a vertebrobasilar junction FD stent. Of the patients without in-stent stenosis on initial DSA, 15 had a second DSA during follow-up. Only one of these patients (6.7%) had new appearance of in-stent stenosis (measuring 5%). Multivariate analysis found statin use to be predictive of in-stent stenosis (p = 0.020, Odds ratio = 0.279 and 95% confidence interval = 0.095–0.821).

Conclusions

In-stent stenosis after FDS placement was seen in 53.2% of cases, which had between 1–50% of stenosis. 82.4% had resolution/improvement of their stenosis. Statin use was protective of in-stent stenosis.
Factors affecting the quality of work-life of nurses: a correlational study
Authors: Kheiri Marzieh , Gholizadeh Leila , Taghdisi Mohammad Hossein , Asghari Elnaz , Musavi Mitra , Mahdavi Nader , Ghaffari Samad
Published: December 2021

Background

Quality of work-life is an important factor in the recruitment and retention of the nursing workforce and their work productivity.

Aims

This study aimed to identify factors that affect the quality of work-life of nurses.

Methods

In this correlational study, 239 nurses employed in a tertiary teaching hospital in Iran completed the study questionnaires, including the quality of work-life questionnaire. The associations between potential independent variables and quality of work-life were examined using multivariate regression analysis.

Results

Participants were mostly women (80.33%) and within the age range of 30–45 years (71.54%). Working in other hospitals, having a second job and health information-seeking behaviours were significant predictors of quality of work-life, explaining 28.68% of the total variance in quality of work-life of nurses.

Conclusions

Improving working standards may prevent nurses from working extra hours or in different occupations. This, along with facilitating the health information-seeking behaviours of nurses, may help improve their quality of work-life by maintaining a better work-life balance and acquiring knowledge and skills that can help with effective management of work and life commitments.
Individualisation, readjustment and athlete codetermination of high-performance training in athletics and volleyball
Authors: Sigmund Philipp , Güllich Arne
Published: December 2021

The study investigated the extent of individualisation, readjustment and athlete codetermination of high-performance training. Individualisation refers to the extent to which the training design is tailored to an athlete's individual wishes, interests, strengths, and weaknesses. Readjustment refers to the adjustment of day-to-day training to an athlete's current physical, health-related and psychological constitution. Athlete codetermination refers to an athlete's involvement in decision-making on the training design. German national-squad members in athletics and volleyball ( n = 336) reported these variables in an online questionnaire. Analyses revealed four central findings: (1) Large parts of athletes’ training were characterised by high degrees of individualisation, readjustment and athlete codetermination. (2) These characteristics were more pronounced in athletics than in volleyball. (3) They explained large parts of the appropriateness of athletes’ training (whether the training was ‘just right’ for an athlete's performance development). Consistently, greater extents of individualisation, readjustment and athlete codetermination of training control were associated with better multi-year performance development. (4) Participation in performance analytics had no additional, specific effect on training appropriateness. All the results consistently applied to both youth age and adult age. In conclusion, greater extents of individualisation, readjustment and athlete codetermination of the training design apparently facilitate long-term training efficiency.
UHMWPE suture induced pseudotumor following arthroscopic rotator cuff repair: A case report
Authors: Yamakado Kotaro
Published: December 2021

UHMWPE suture shows excellent biocompatibility and complication associated with suture debris had not been described before in shoulder surgery.

In this study, a case of a 38-year-old man with a wear debris pseudotumor mimicking osteochondromatosis in the subacromial bursa five years after arthroscopic rotator cuff repair using a composite braid suture (a polydioxanone core with a sleeve of UHMWPE) was presented.

Histological examination confirmed the presence of suture fragments surrounded with the osteochondral layer without inflammatory reactions. The present study implies the potential risk of free fragmented remnants from the UHMWPE suture. Because of the silent nature of the histological response, a high index of suspicion should be necessary to disclose the chanciness of its use.
Is training doctors in medical certification effective? Evidence from a prospective study in the Philippines
Authors: Rebanal Jomilynn , Adair Tim , Mikkelsen Lene
Published: December 2021

Background

Correct certification of causes of death by physicians according to International Classification of Diseases (ICD) rules is essential to generate mortality statistics of the quality needed to guide public health policy debates and reliably monitor the impact of health interventions. Several efforts to train doctors have been undertaken in the Philippines to improve Medical Certification of Causes of Death (MCCOD). However, there is very little evidence about the long-term effects of training interventions for medical certification.

Objective

To test whether there were measurable long-term impacts of this large-scale training intervention for improving medical certification and reducing different types of certification errors.

Method

We assessed the quality of 2100 MCCOD completed before face-to-face training with those written by the same doctors 6 months after the training. An assessment tool was used to evaluate the quality of MCCOD.

Results

Less than 1% of the 2100 MCCOD assessed prior to the training were completely error-free, increasing to 19.2% 6 months after the training. On average, the number of errors per certificate fell from 2.2 pre-training to 1.3, six months after training. Importantly, there was a 38% decrease in writing ill-defined causes on the last line, which is particularly important for the policy utility of data.

Conclusion

Training doctors in correct medical certification can have a long-term impact on medical certification practices.

Implications

Shorter, more focused, trainings that address the most common medical certification errors could have an even greater impact on medical certification practices.
Double Suicide Due to the Ingestion of Levamisole-Adulterated Cocaine: Case Report and Review of the Literature
Authors: Serinelli Serenella , Bonaccorso Luigi , Furnari Carmelo , Gitto Lorenzo
Published: December 2021

Suicide is a major public health issue and the risk of attempting and committing suicide increases with age. We present the case of an elderly couple who decided to commit suicide together by self-poisoning using levamisole-adulterated cocaine. The choice of committing a double suicide, the method selected (self-poisoning), the drug self-administered (cocaine), and the route of administration (ingestion) are events rarely encountered in the forensic pathology practice, especially not in combination. In this article, we will review the literature regarding the frequency and features of these methods of suicide. An overview of the effects and mechanism of action of levamisole is also provided, highlighting the importance of including this substance and its metabolites in the routine toxicological analyses for cocaine deaths.
Effects of Internal and External CSR on Supportive and Harmful Employee Attitudes
Authors: Kim Jungsun (Sunny) , Milliman John F. , Lucas Anthony F.
Published: December 2021

Prior studies have suggested that corporate social responsibility (CSR) contributes to a hospitality organization’s competitive advantage by influencing employee attitudes. However, the mechanisms driving employees’ responses to different types of CSR activities remain largely unexplored. Based on social exchange and social identity theories, we examined the mechanisms through which external and internal CSR activities influence employees’ perceived organizational justice and identification, and their subsequent outcomes (i.e., organizational commitment and turnover intention). We collected data from the employees of a hospitality company operating in the United States and used confirmatory factor analysis and structural equation modeling for data analysis. The results showed that internal CSR activities had significant sequential effects on organizational justice, organizational identification, and organizational commitment as well as turnover intention. External CSR activities had significant indirect effects on organizational commitment via organizational identification. These findings reinforce the notion that external and internal CSR operate through different mediating mechanisms. We discussed the main findings of this study in terms of their theoretical implications for our understanding of the psychology behind CSR, as well as social exchange and social identity theories. The results suggest that both external and internal CSR have particular importance as a means of supporting a hospitality company’s efforts to foster employee identification with the company, and thereby improve employee attitudes at work. We closed by discussing the practical implications of our results, including recommendations for hospitality operators.
Implicit motives as the missing link between visionary leadership, approach and avoidance motivation, and vision pursuit
Authors: Kehr Hugo M. , Voigt Julian , Rawolle Maika
Published: December 2021

An unresolved question in visionary leadership research is, why must visions be high in imagery to cause affective reactions and be motivationally effective? Research in motivation psychology has shown that pictorial cues arouse implicit motives. Thus, pictorial cues from vision-induced imagery should arouse a follower’s implicit motives just like a real image. Hence, our fundamental proposition is that follower implicit motives and follower approach motivation serially mediate the relationship between leader vision and followers’ vision pursuit. We also examine the case of negative leader visions, with the central propositions that a negative leader vision arouses a follower’s implicit fear motives and that the follower’s implicit fear motives and follower avoidance motivation serially mediate the relationship between negative leader vision and the follower’s fear-related behaviors. Lastly, we assert that multiple implicit follower motives aroused by a multithematic leader vision exert additive as well as interaction effects on the follower’s vision pursuit. Plain Language Summary An unresolved question in leader vision research concerns why visions need to be high in imagery in order to elicit affective reactions in followers and be motivationally effective? Research in motivation psychology has shown that pictorial cues can arouse a person's implicit motives. It would thus be reasonable to expect that pictorial cues from leader vision-induced imagery arouse a follower's implicit motives just like a real image. Based on this reasoning, our key proposition is that follower implicit motives and follower approach motivation serially mediate the relationship between leader vision and followers' vision pursuit. We also integrate the special case of negative leader visions into our theorizing, with the central propositions that a negative leader vision arouses a follower's implicit fear motives, and that the follower's implicit fear motives and follower avoidance motivation serially mediate the relationship between negative leader vision and the follower's fear-related behaviors. Lastly, based on the distinction between mono- and multithematic visions, the latter of which with the potential to arouse more than one implicit motive simultaneously, we assert that multiple implicit follower motives aroused by a multithematic leader vision exert additive as well as interaction effects on the follower's vision pursuit.
Blindness paving the path to the diagnosis of metastatic prostate carcinoma: A unique case presentation
Authors: Jain Aadhar , Nayan Anveshi , Patwardhan Sujata
Published: December 2021

Background:

Intracranial metastases from prostate adenocarcinoma are very unusual and typically occur late in the course of the disease, and initial presentation with symptomatic brain involvement, especially vision loss is very rare (with this being only the sixth such reported case to the best of our knowledge). The present case elucidates how a diagnosis was reached in such a scenario and the management provided.

Case presentation:

A 66-year-old gentleman presented with loss of vision and headache with no other ocular or neurological complaint. Computed tomography (CT) of his head revealed a destructive lesion involving the clivus and a space-occupying lesion (SOL) in occipito-parietal region. Detailed inquiry regarding the possible primary source of suspected the metastatic lesion revealed an increased frequency of urination, nocturia, and significant weight loss. His serum prostate-specific antigen (PSA) levels were raised. He was treated by surgical hormonal therapy and his visual symptoms improved.

Conclusion:

Awareness of such a presentation can lead to an accurate diagnosis. Initiation of appropriate therapy can successfully alleviate the neurologic deficits.
Critical companionship: Some sensibilities for studying the lived experience of data subjects
Authors: Ziewitz Malte , Singh Ranjit
Published: December 2021

What are the challenges of turning data subjects into research participants—and how can we approach this task responsibly? In this paper, we develop a methodology for studying the lived experiences of people who are subject to automated scoring systems. Unlike most media technologies, automated scoring systems are designed to track and rate specific qualities of people without their active participation. Credit scoring, risk assessments, and predictive policing all operate obliquely in the background long before they come to matter. In doing so, they constitute a problem not only for those subject to these systems but also for researchers who try to study their experience. Specifically, we identify three challenges that are distinct to studying experiences of automated scoring: limited awareness, embeddedness, and ongoing inquiry. Starting from the observation that coming to terms with one's position as a data subject constitutes a form of learning in its own right, we propose a research strategy called critical companionship. Originally articulated in the context of nursing research, critical companionship invites us to accompany a data subject over time, paying critical attention to how the participant's and the researcher's inquiries complicate and constitute each other. We illustrate the strengths and limitations of this methodology with materials from a recent study we conducted about people's credit repair practices and sketch a set of sensibilities for studying contemporary scoring systems from the margins.
Gender-specific nursing needs of people with multiple sclerosis: A scoping review
Authors: Schermann Karoline , Kreyer Christiane , Pallauf Martin , Deufert Daniela
Published: December 2021

Women and men with multiple sclerosis (MS) experience different disease courses and occurring symptoms. These lead to different gender-specific needs. However, gender-specific needs are often elusive for nurses and therefore difficult to address in daily care. Thus, our aim is to describe gender-specific needs of people with MS. A scoping review was conducted, covering papers published between 1999 and 2019. Overall, 26 studies were identified, and a deductive coding process was applied based on Henderson's Nursing Need Theory. The PRISMA-ScR checklist was used to write the scoping review. Different needs of female and male patients with MS are described in eight categories of Henderson’s Nursing Need Theory, occurring in mobility and elimination. The analysis shows differences in communication about the disease, individual needs, and the acceptance of support. To address these differences, training on gender-sensitive care should be offered in nursing education and for nurses.
Discovering Tonal Profiles with Latent Dirichlet Allocation
Authors: Moss Fabian C. , Rohrmeier Martin
Published: December 2021

Music analysis, in particular harmonic analysis, is concerned with the way pitches are organized in pieces of music, and a range of empirical applications have been developed, for example, for chord recognition or key finding. Naturally, these approaches rely on some operationalization of the concepts they aim to investigate. In this study, we take a complementary approach and discover latent tonal structures in an unsupervised manner. We use the topic model Latent Dirichlet Allocation and apply it to a large historical corpus of musical pieces from the Western classical tradition. This method conceives topics as distributions of pitch classes without assuming a priori that they correspond to either chords, keys, or other harmonic phenomena. To illustrate the generative process assumed by the model, we create an artificial corpus with arbitrary parameter settings and compare the sampled pieces to real compositions. The results we obtain by applying the topic model to the musical corpus show that the inferred topics have music-theoretically meaningful interpretations. In particular, topics cover contiguous segments on the line of fifths and mostly correspond to diatonic sets. Moreover, tracing the prominence of topics over the course of music history over [Formula: see text]600 years reflects changes in the ways pitch classes are employed in musical compositions and reveals particularly strong changes at the transition from common-practice to extended tonality in the 19th century.
The Perfect Storm: Organizational Dissonance and the Global Pandemic
Authors: Jun Jin
Published: December 2021

An incongruity between what is said and done can be harmful. Cultivating consonance is a place to bring organizations and nurses together.
Biceps tenodesis combined with rotator cuff repair increases functional status and elbow strength
Authors: Ihsan Kilic Ali , Hapa Onur , Ozmanevra Ramadan , Demirhan Demirkiran Nihat , Gursan Onur
Published: December 2021

Purpose

The aim of the present study was to prospectively evaluate the elbow flexion and supination strengths and the functional outcomes of patients following arthroscopic rotator cuff repair combined with simultaneous biceps tenodesis.

Methods

19 patients who underwent arthroscopic rotator cuff repair and biceps tenodesis with at least 24 months of follow-up were included. Patients were evaluated using a visual analog scale (VAS) for bicipital groove pain, American Shoulder and Elbow Surgeons (ASES), and constant scores (CS), biceps apex distance (BAD), elbow flexion, and supination strengths.

Results

The VAS for biceps groove measurement averages in the postoperative 6th, 12th, and 24th months was lower in comparison to preoperative data and was considered to be statistically significant ( p < .05). The constant score, an average of all postoperative measurements and scores, was found to be higher than preoperative values and was considered to be statistically significant ( p < .01). There was a significant difference in the operated and non-operated forearm supination and elbow flexion muscle strength measurements at the postoperative 3- and 6-month follow-ups ( p < .01).

Conclusion

Arthroscopic biceps tenodesis into the anchors of the lateral row in combination with rotator cuff repair provides an increase in the strength of elbow flexion and forearm supination, while decreasing pain.

Level of Evidence

Level IV
Refractory Torsades de Pointes Due to Dofetilide Overdose
Authors: Crosby James , Bhopalwala Huzefa , Kharawala Amrin , Dewaswala Nakeya , Ganti Subramanya Shyam , Bhopalwala Adnan
Published: December 2021

Dofetilide, a class III antiarrhythmic, is widely used in the treatment of cardiac arrhythmias. Antiarrhythmic drugs can have a long duration of action that prolongs the QT interval. This causes bradycardia that predisposes to R-on-T phenomenon subsequently leading to torsades de pointes (TdP). This necessitates constant monitoring to prevent or treat ventricular arrhythmias or bradycardia associated with cardiac medications. Although extremely rare, dofetilide overdose has been described in the literature. However, no evidence found in the current literature required prolonged intervention after the initial acute stabilization, leading to scarcity of data for treatment of ongoing dofetilide overdose. We present the case of an intentional dofetilide overdose in a 61-year-old Caucasian woman with a history of congestive heart failure, atrial fibrillation, stage IIIb chronic kidney disease, diabetes mellitus type II, hypothyroidism, morbid obesity, and hypertension that required extensive interventions for refractory TdP that lasted 4 days. Therapeutic as well as excess dosage of dofetilide can lead to TdP, which is usually controlled by decreasing the dose or terminating drug administration. If the arrhythmia is not resolved, guidelines recommend management with activated charcoal if ingestion is within 15 minutes, followed by administration of 2 g IV (intravenous) magnesium and addressing the electrolyte imbalance. However, if the arrhythmia is persistent due to ongoing dofetilide toxicity, isoproterenol is given as a bridge to overdrive pacing and dopamine is used as an alternative to isoproterenol.