bluuebunny/crossref_metadata_2025 huggingface dataset:
Practical solutions to logistics and supply chain issues posed by the covid-19 Crisis and similar crises: a literature review
Authors: Zachari KABORE Zachari KABORE , HOUSSAS M’Bark , BOURMA Khalid
Published: May 2023

Covid-19 pandemic is still ongoing, and its economic consequences are far from being limited. This pandemic, as others, negative economic impacts are strongly related to logistics and supply chain shortcomings. Finding appropriate solutions (strategies, practices, and tools) to address these shortcomings will ensure the recovery of economic activities that are currently suffering from the blows of the current crisis. This paper aims at this goal by providing a literature review focused on practical solutions implemented around the world to give practitioners a set of turnkey solutions, already implemented by counterparts or competitors, to cope effectively with the pandemic. Bibliographical resources are gathered from Web of science and Google Scholar. An analysis is performed followed by a presentation of insightful findings. Finally, research opportunities are proposed to fill the identified gaps in the current literature.
ADA as main biochemical marker in patients with tuberculous effusion
Authors: Janković Jelena , Ilić Branislav , Đurđević Nataša , Jandrić Aleksandar
Published: May 2023

Tuberculous pleuritis (TP) is one of the most common extra-pulmonary tuberculosis form. Because of tuberculous pleurisy is hard to diagnose due to slow course of disease and lack of specificity in symptoms and diagnostic methods. In that reason, we need multidisciplinary approach and efficient biomarkers. Acid-fast bacilli (AFB) staining, cultures and pathophysiological biopsy finding from the majority of patients are positive only in less than 10%. Löwenstein culture results need time about 6-8 weeks what delays diagnosis. Adenosine deaminase (ADA) is biomarker with high sensitivity and specificity (more than 90%) and considered as gold standard of biomarkers in the diagnosis of TP. It is very hard to distinguish malignant from TP with lymphocyte predomination, but in patient with malignant pleural effusion the level of ADA is decreased, opposite from TP. ADA in pleural punctate is a fast, simple, efficient and economical way for clarification the etiology of the pleural effusion as tuberculous pleurisy. Also, many studies have proved the role of ADA in the response to treatment for tuberculosis at follow up period.
OPTIMAL ALLOCATION OF PENSION FUNDS. SENSITIVITY ANALYSES OF THE ADJUSTED SHARPE RATIO
Authors: Hovhannisyan Rita
Published: May 2023

In order to optimally manage pension funds, an optimal portfolio is constructed under various constraints. The Sharpe and adjusted Sharpe ratios are calculated. An assessment of the symmetry and spread coefficients of the optimal portfolio yield is made. A sensitivity analysis of the optimal portfolio is performed and founded that when using the Sharpe ratio as a decision criterion, the optimal limit for the country and asset is 35%, while under RA law it is 15%, and the obtained result is stable with respect to symmetry and spread.
L’évolution de l’assurance contre l’incendie
Authors: Parizeau Gérard
Published: May 2023

Cet article relate les développements importants de l'assurance des débuts jusqu'en 1957, en mettant l'emphase sur l'assurance incendie au Canada. Il a paru dans la revue Assurances en 1957 (volume 25, no 2, pages 67-118).
Lēmumu pieņemšana ceļā uz ilgtspējīgu enerģētiku
Authors:   , Āboltiņš Reinis
Published: May 2023

Promocijas darbā izveidots lēmumu pieņemšanas algoritms, kas ņem vērā esošās zināšanas par šķēršļiem un politikām, kas kavē vai veicina ilgtspējīgas enerģijas attīstību, koncentrējoties uz lēmumu pieņemšanas posmu un soļu identificēšanu un analīzi pilnā politikas dzīves ciklā. Darba gaitā noteiktas arī piemērotas analīzes metodes katrā lēmumu pieņemšanas posmā un solī, lai atbalstītu lēmumu pieņemšanu par enerģētikas un klimata politiku, integrējot šīs metodes lēmumu pieņemšanas procesā, lai nodrošinātu tādu politikas dzīves ciklu, kas rada ilgtspējīgas enerģētikas sistēmu.
Decision-making in Transition to Sustainable Energy
Authors:   , Āboltiņš Reinis
Published: May 2023

The goal of the Thesis is to create an algorithm of decision-making, which takes into account existing knowledge about barriers and policies that hamper or facilitate development of sustainable energy by focusing on identifying and analysing stages and steps of decision-making throughout policy lifecycle, as well as identifying suitable methods of analysis at each stage and step of making decisions to support decision-making about energy and climate policy, and integrating those in the decision-making process with the purpose of ensuring a policy lifecycle leading to sustainable energy system.
NASTANAK I RAZVOJ PRAVA ZADRŽAVANјA U RAZLIČITIM EVROPSKIM DRŽAVAMA
Authors: PAVIĆEVIĆ Aleksandra
Published: May 2023

Korišćenjem istorijskopravnog i aksiološkog metoda autor u radu razmatra i kritički ocjenjuje genezu prava zadržavanja, kao specifičnog in- stituta građanskog prava, počev od nastanka u rimskom pravu, preko srednjovi- jekovne regulative u pojedinim evropskokontinentalnim zakonodavstvima, do konačne kodifikacije u građanskim zakonicima. Predmet razmatranja u radu su klјučni segmenti ovog instituta u nekadašnjoj domaćoj regulativi, kao i u pojed- inim evropskim regulativama, sa fokusom na nekadašnjem austrijskom i francus- kom rješenju. Cilј rada je formulisanje odgovora na pitanja: koji su modeli regulati- va prava zadržavanja postojali kroz vrijeme, kako su i zašto evoluirali; kakav je bio odnos različitih zakonodavaca prema ovom institutu; i otkrivanje ratia njegovog sve šireg priznavanja. Autor ocjenjuje da je geneza evropske retencije kroz vri- jeme - put od njene izričite zabrane, preko kazuističkog priznavanja na nivou izuz-etka, pa do formulisanja opšteg pravila o retenciji građanskog i trgovačkog prava, te da ona u savremenoj fizionomiji oličava ne samo sredstvo pritiska na neured- nog dužnika, već i efikasno sredstvo namirenja, a u ulozi instrumenta zaštite pov- jerenja u pravni promet, pravičnosti (equitas) i ekvivalencije uzajamnih davanja u dužničko-povjerilačkim odnosima.
ODREĐENE NEDOUMICE I PROBLEMI U KRIMINALISTIČKOJ PRAKSI REAGOVANJA NA KRIVIČNO DJELO ,,POLNO UZNEMIRAVANJE”
Authors: MILADINOVIĆ Aleksandar
Published: May 2023

U radu se daje pregled određenih nedoumica i problema koji se susreću u petogodišnjoj kriminalističkoj praksi reagovanja na krivično djelo ,,Pol- no uznemiravanje” koje je u Krivičnom zakoniku Republike Srpske inkriminisano 2017. godine. Nedoumice i problemi na koje se ukazuje se prikazuju iz aspekta rada policije, odnosno ukazuje se na određene probleme primijetne u radu policije koji su u većoj ili manjoj mjeri uslovljeni nedoumicama u inkriminaciji ovog novog krivičnog djela. U prvom redu ukazuje se na neodređenost, odnosno nepreciznost radnje izvršenja ovog krivičnog djela, zatim na spornost nužnosti posljedice djela, kao i na problem subjektivne strane djela. U radu se ukazuje i na određene prob- leme koji se odnose na gonjenje po prijedlogu što nije primarno vezano za ovo krivično djelo, međutim, problemi se svakako ispoljavaju u većoj mjeri i kod ovog krivičnog djela.
Prikaz udžbenika
Authors: KAROVIĆ Sadmir , MURTEZIĆ Arben
Published: May 2023

U Bihaću je, u martu 2021. godine, u izdanju Pravnog fakulteta Univerziteta u Bihaću izašao iz štampe udžbenik „Krivično procesno pravo: uvod i opšti dio“, šesto izmijenjeno i dopunjeno izdanje, izdavača Grafomark Laktaši. Udžbenik je proizašao iz opravdane i realne potrebe, s obzirom na aktuelne promjene norma- tivnog krivičnog procesnog ambijenta kao rezultata stupanja na snagu i primjenu Zakona o izmjenama i dopunama Zakona o krivičnom postupku Republike Srsp- ke iz 2018. i 2021. godine, Zakona o izmjenama i dopunama Zakona o krivičnom postupku Federacije Bosne i Hercegovine iz 2020. godine i Zakona o izmjenama i dopunama Zakona o krivičnom postupku Brčko Distrikta Bosne i Hercegovine iz 2019. godine. S obzirom na sadržaj, metodološki koncept i kvalitativnu komponen- tu, navedeno izdanje udžbenika sa razlogom zavređuje posebnu pažnju naučne i stručne javnosti jer omogućava svim zainteresovanim, a prije svega studentima osnovnih, master i doktorskih studija na pravnim fakultetima i drugim srodnim fakultetima kao i praktičarima (sudije, tužioci, advokati, ovlaštena službena lica, vještaci i dr.), da se upoznaju sa materijom krivičnoprocesne prirode. Navedena krivičnoprocesna materija je adekvatno prilagođena normativnom krivičnopro-cesnom okviru bosanskohercegovačkog zakonodavstva 15. marta 2021. godine. Ovaj udžbenik su recenzirali akademik prof. dr Stanko Bejatović, redovni profesor Pravnog fakulteta u Kragujevcu i prof. dr Drago Radulović, redovni profesor Prav- nog fakulteta u Podgorici.
The Hazard of Electric Field Increment in the Damaged Silicon-Rubber and Porcelain Insulators
Authors: Shemshadi Asaad , Khorampour Pourya
Published: May 2023

In power transmission lines, it is necessary to isolate the inherent voltage parts from each other and from zero potential. An insulator is defined as having a high degree of electrical insulation between the conductors and the brackets. Insulators also allow for mechanical conductivity of the conductor and ground. The presence of a broken insulator can alter the stress distribution. In this paper, the effect of mechanical insulation cracking (chattering) on electric field in two common types of insulators (porcelain and silicone rubber) and electric potential distribution models are analyzed. First, the electric field and electric potential patterns in the solid insulator are examined. In the following, the insulator is assumed to be broken, and the electric field and electric potential patterns for a broken insulator relative to the basic insulator shape are illustrated and compared. The results show that the presence of insulation cracking under dry and environmentally benign conditions affects the stress distribution pattern within and around the insulator. Finally, a comparison between the effect of fracture on the electric field and the potential distribution patterns in different parts of the insulator is discussed in detail.
p-Analogue of biperiodic Pell and Pell–Lucas polynomials
Authors:   Erzincan Binali Yıldırım University, Kuloğlu Bahar , Özkan Engin ,   Erzincan Binali Yıldırım University, Shannon Anthony G. ,   Warrane College, University of New South Wales
Published: May 2023

In this study, a binomial sum, unlike but analogous to the usual binomial sums, is expressed with a different definition and termed the p-integer sum. Based on this definition, p-analogue Pell and Pell–Lucas polynomials are established and the generating functions of these new polynomials are obtained. Some theorems and propositions depending on the generating functions are also expressed. Then, by association with these, the polynomials of so-called ‘incomplete’ number sequences have been obtained, and elegant summation relations provided. The paper has also been placed in the appropriate historical context for ease of further development.
Oxygen levels at the time of activation determine T cell persistence and immunotherapeutic efficacy
Authors: Cunha Pedro P , Minogue Eleanor , Krause Lena CM , Hess Rita M , Bargiela David , Wadsworth Brennan J , Barbieri Laura , Brombach Carolin , Foskolou Iosifina P , Bogeski Ivan , Velica Pedro , Johnson Randall S
Published: May 2023

Oxygenation levels are a determinative factor in T cell function. Here, we describe how oxygen tensions sensed by mouse and human T cells at the moment of activation act to persistently modulate both differentiation and function. We found that in a protocol of CAR-T cell generation, 24 hr of low oxygen levels during initial CD8+ T cell priming is sufficient to enhance antitumour cytotoxicity in a preclinical model. This is the case even when CAR-T cells are subsequently cultured under high oxygen tensions prior to adoptive transfer. Increased hypoxia-inducible transcription factor (HIF) expression was able to alter T cell fate in a similar manner to exposure to low oxygen tensions; however, only a controlled or temporary increase in HIF signalling was able to consistently improve cytotoxic function of T cells. These data show that oxygenation levels during and immediately after T cell activation play an essential role in regulating T cell function.
The Plasmodium falciparum apicoplast cysteine desulfurase provides sulfur for both iron-sulfur cluster assembly and tRNA modification
Authors: Swift Russell P , Elahi Rubayet , Rajaram Krithika , Liu Hans B , Prigge Sean T
Published: May 2023

Iron-sulfur clusters (FeS) are ancient and ubiquitous protein cofactors that play fundamental roles in many aspects of cell biology. These cofactors cannot be scavenged or trafficked within a cell and thus must be synthesized in any subcellular compartment where they are required. We examined the FeS synthesis proteins found in the relict plastid organelle, called the apicoplast, of the human malaria parasite Plasmodium falciparum. Using a chemical bypass method, we deleted four of the FeS pathway proteins involved in sulfur acquisition and cluster assembly and demonstrated that they are all essential for parasite survival. However, the effect that these deletions had on the apicoplast organelle differed. Deletion of the cysteine desulfurase SufS led to disruption of the apicoplast organelle and loss of the organellar genome, whereas the other deletions did not affect organelle maintenance. Ultimately, we discovered that the requirement of SufS for organelle maintenance is not driven by its role in FeS biosynthesis, but rather, by its function in generating sulfur for use by MnmA, a tRNA modifying enzyme that we localized to the apicoplast. Complementation of MnmA and SufS activity with a bacterial MnmA and its cognate cysteine desulfurase strongly suggests that the parasite SufS provides sulfur for both FeS biosynthesis and tRNA modification in the apicoplast. The dual role of parasite SufS is likely to be found in other plastid-containing organisms and highlights the central role of this enzyme in plastid biology.
Structural and mechanistic insights into the MCM8/9 helicase complex
Authors: Weng Zhuangfeng , Zheng Jiefu , Zhou Yiyi , Lu Zuer , Wu Yixi , Xu Dongyi , Li Huanhuan , Liang Huanhuan , Liu Yingfang
Published: May 2023

MCM8 and MCM9 form a functional helicase complex (MCM8/9) that plays an essential role in DNA homologous recombination repair for DNA double-strand break. However, the structural characterization of MCM8/9 for DNA binding/unwinding remains unclear. Here, we report structures of the MCM8/9 complex using cryo-electron microscopy single particle analysis. The structures reveal that MCM8/9 is arranged into a heterohexamer through a threefold symmetry axis, creating a central channel that accommodates DNA. Multiple characteristic hairpins from the N-terminal oligosaccharide/oligonucleotide (OB) domains of MCM8/9 protrude into the central channel and serve to unwind the duplex DNA. When activated by HROB, the structure of MCM8/9’s N-tier ring converts its symmetry from C3 to C1 with a conformational change that expands the MCM8/9’s trimer interface. Moreover, our structural dynamic analyses revealed that the flexible C-tier ring exhibited rotary motions relative to the N-tier ring, which is required for the unwinding ability of MCM8/9. In summary, our structural and biochemistry study provides a basis for understanding the DNA unwinding mechanism of MCM8/9 helicase in homologous recombination.
WASPAS method and Aczel-Alsina aggregation operators for managing complex interval-valued intuitionistic fuzzy information and their applications in decision-making
Authors: Fang Haojun , Mahmood Tahir , Ali Zeeshan , Zeng Shouzhen , Jin Yun
Published: May 2023

Aczel-Alsina t-norm and t-conorm are a valuable and feasible technique to manage ambiguous and inconsistent information because of their dominant characteristics of broad parameter values. The main theme of this analysis is to explore Aczel-Alsina operational laws in the presence of the complex interval-valued intuitionistic fuzzy (CIVIF) set theory. Furthermore, we derive the theory of aggregation frameworks based on Aczel-Alsina operational laws for managing the theory of CIVIF information. The CIVIF Aczel-Alsina weighted averaging (CIVIFAAWA), CIVIF Aczel-Alsina ordered weighted averaging (CIVIFAAOWA), CIVIF Aczel-Alsina hybrid averaging (CIVIFAAHA), CIVIF Aczel-Alsina weighted geometric (CIVIFAAWG), CIVIF Aczel-Alsina ordered weighted geometric (CIVIFAAOWG) and CIVIF Aczel-Alsina hybrid geometric (CIVIFAAHG) operators are proposed, and their well-known properties and particular cases are also detailly derived. Further, we derive the theory of the WASPAS method for CIVIF information and evaluate their positive and negative aspects. Additionally, we demonstrate the multi-attribute decision-making (MADM) strategy under the invented works. Finally, we express the supremacy and dominancy of the invented methods with the help of sensitive analysis and geometrical shown of the explored works.
Analysis of IGHA1 and other salivary proteins post half marathon in female participants
Authors: Maruyama Yosuke , Seki Tomoaki , Ando Seiichi , Tanabe Hiroki , Mori Hitoshi
Published: May 2023

Background

High-intensity exercise (HIE), such as that in marathons and triathlons, suppresses transient local and systemic immunity. Serum and salivary immunoglobulin heavy constant alpha 1 (IGHA1) are major markers of immunosuppression by HIE. Although much is known about the systemic immunosuppressive response, little is known about its local response in the oral cavity, lungs, bronchial tubes, and skin. The oral cavity allows bacteria or viruses to enter the body. Saliva covers the epidermis of the oral cavity and plays an important role in the local stress response by preventing infection. In this study, we examined the properties of saliva secreted during the local stress response for half-marathon (HM) induced IGHA1 protein expression using quantitative proteomics.

Methods

The Exercise Group (ExG) (19 healthy female university students) participated in a HM race. The Non-Exercise Group (NExG) (16 healthy female university students) did not participate in the ExG. The ExG saliva samples were collected 1 h pre and 2 h and 4 h post-HM. The NExG saliva samples were collected at the same time intervals. The saliva volume, protein concentration, and relative IGHA1 expression were analyzed. In addition, 1 h pre and 2 h post- HM saliva samples were analyzed by iTRAQ. The identified factors in iTRAQ were analyzed for the ExG and the NExG using western blotting.

Results

We identified kallikrein 1 (KLK1), immunoglobulin kappa chain (IgK), and cystatin S (CST4) as suppression factors, as well as IGHA1, which has been reported to be an immunological stress marker. IGHA1 (p= 0.003), KLK1 (p= 0.011), IGK (p= 0.002), and CST4 (p= 0.003) were suppressed 2 h post-HM compared with their levels pre HM, and IGHA1 (p< 0.001), KLK1 (p= 0.004), and CST4 (p= 0.006) were suppressed 4 h post-HM. There was also a positive correlation between IGHA1, IGK, and CST4 levels at 2 and 4 h post-HM. In addition, KLK1 and IGK levels at 2 h post-HM were positively correlated.

Conclusion

Our study demonstrated that the salivary proteome is regulated, and antimicrobial proteins are suppressed post-HM. These results suggest that oral immunity was transiently suppressed post-HM. The positive correlation of each protein at 2 and 4 h post-HM suggests that the suppressed state was similarly regulated up to 4 h after a HM. The proteins identified in this study may have applications as stress markers for recreational runners and individuals who perform moderate to HIE on a regular basis.