bluuebunny/crossref_metadata_2025 huggingface dataset:
Unlocking the Potential of Drug Delivery Systems: A Comprehensive
Review of Formulation Strategies and Technologies in the Field of
Pharmaceutics
Authors: Rajan Nitin , Kanaujiya Shubham
Published: December 2023

:

The creation of innovative drug delivery systems to enhance therapeutic effectiveness,
safety, and patient compliance has resulted in considerable developments in pharmaceutics in recent
years. The most recent formulation techniques and technologies are reviewed in this article to improve
medication distribution and accomplish specific therapeutic goals.

:

This article thoroughly summarizes the most recent formulation techniques and technologies used to
enhance medication delivery and provide specific therapeutic effects. It discusses the variety of medication
delivery methods, including nanoparticles, liposomes, micelles, and dendrimers, and explores
the application of nanotechnology and biotechnology in drug delivery. Additionally, the paper emphasizes
the significance of targeted drug delivery systems and their capacity to cross biological barriers
including the blood-brain barrier and tumor microenvironment.

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The review also addresses the challenges faced in developing and commercializing drug delivery
systems and suggests potential solutions to overcome them. Furthermore, the article emphasizes the
role of computational modeling and simulation in designing and optimizing drug delivery systems.

:

Overall, this review paper offers insightful information for pharmaceutics researchers, scientists, and
practitioners that will help in the creation of novel drug delivery systems that improve patient outcomes
and quality of life.
Antitumor Activity of a Lectin Purified from Punica granatum Pulps against Ehrlich
Ascites Carcinoma (EAC) Cells
Authors: Nurujjaman Md , Mashhoor Tanjila , Pronoy Tasfik Ul Haque , Auwal Abdul , Hasan Md Robiul , Islam Shaikh Shohidul , Hasan Imtiaj , Asaduzzaman A.K.M. , Uddin Md Belal , Kabir Syed Rashel , Islam Farhadul
Published: December 2023

Background:

Lectins are carbohydrate-binding proteins with various pharmacological activities, such
as antimicrobial, antidiabetic, antioxidant, and anticancer. Punica granatum fruit extract has traditional uses,
however, the anti-cancer activity of purified lectin isolated from P. granatum pulp is yet to be reported.

Objective:

The goals of this study are purification, characterization of the lectin from P. granatum, and examination of the purified lectin's anticancer potential.

Methods:

Diethylaminoethyl (DEAE) ion-exchange chromatography was used to purify the lectin, and SDSPAGE was used to check the purity and homogeneity of the lectin. Spectrometric and chemical analysis were
used to characterize the lectin. The anticancer activity of the lectin was examined using in vivo and in vitro functional assays.

Results:

A lectin, designated as PgL of 28.0 ± 1.0 kDa molecular mass, was isolated and purified from the pulps
of P. granatum and the lectin contains 40% sugar. Also, it is a bivalent ion-dependent lectin and lost its 75%
activity in the presence of urea (8M). The lectin agglutinated blood cells of humans and rats, and sugar molecules
such as 4-nitrophenyl-α-D-manopyranoside and 2- nitrophenyl -β- D-glucopyranoside inhibited PgL’s hemagglutination activity. At pH ranges of 6.0-8.0 and temperature ranges of 30°C -80°C, PgL exhibited the highest agglutination activity. In vitro MTT assay showed that PgL inhibited Ehrlich ascites carcinoma (EAC) cell growth in a
dose-dependent manner. PgL exhibited 39 % and 58.52 % growth inhibition of EAC cells in the mice model at
1.5 and 3.0 mg/kg/day (i.p.), respectively. In addition, PgL significantly increased the survival time (32.0 % and
49.3 %) of EAC-bearing mice at 1.5 and 3.0 mg/kg/day doses (i.p.), respectively, in comparison to untreated
EAC-bearing animals (p < 0.01). Also, PgL reduced the tumor weight of EAC-bearing mice (66.6 versus 39.13%;
p < 0.01) at the dose of 3.0 mg/kg/day treatment. Furthermore, supplementation of PgL restored the haematological parameters toward normal levels deteriorated in EAC-bearing animals by the toxicity of EAC cells.

Conclusion:

The results indicated that the purified lectin has anticancer activity and has the potential to be developed as an effective chemotherapy agent.
An Active Compound from the Pyrazine Family Induces Apoptosis by Targeting the
Bax/Bcl2 and Survivin Expression in Chronic Myeloid Leukemia K562 Cells
Authors: Rostampour Saeedeh , Eslami Farhad , Babaei Esmaeil , Mostafavi Hossein , Mahdavi Majid
Published: December 2023

Background:

It has been established that pyrazine derivatives, which have widespread bioactivities,
can effectively treat cancer.

Objectives:

In this study, we investigated the effects of 2-methoxy-5-(oxiran-2-ylmethyl) phenyl pyrazine-2- carboxylate
(2-mOPP), a new pyrazine derivative, on proliferation, viability, and apoptosis induction in human leukemia
K562 cells.

Methods::

For this purpose, the K562 cells were treated with various concentrations (20-120 μM) of the 2-mOPP
for 24-72 hours. Cell viability was determined by MTT growth inhibition assay. Apoptotic activity of 2-mOPP
was investigated morphologically by Hoechst staining, cell surface expression assay of phosphatidylserine by
Annexin-V/PI technique, as well as DNA fragmentation assay. The effect of 2-mOPP on the K562 cell cycle was
studied by flow cytometry. To determine the impact of 2-mOPP on the expression of intrinsic apoptosis-related
genes, Bcl2 (anti-apoptotic), Bax (pro-apoptotic), and Survivin genes expression levels were evaluated before and
after treatment with 2-mOPP through Real-Time PCR analysis.

Results::

The results revealed that 2-mOPP inhibited viability with IC50 of 25μM in 72 h. Morphological changes
assessment by fluorescence microscopy, Annexin V/PI double staining by flow cytometry, and DNA ladders
formation upon cell treatment with the 2-mOPP showed that this compound induces apoptosis at IC50 value. Cell
cycle arrest was observed in the G0/G1 phase, and the sub-G1 cell population (the sign of apoptosis) increased in a
time-dependent manner. Low expression levels of Bcl2 and Survivin in K562 cells were observed 24-72 h after
treatment. Along with the down-regulation of Survivin and Bcl2, the expression of Bax was increased after treatment
with 2-mOPP.

Conclusion:

These findings demonstrate that the new pyrazine derivative plays a crucial role in blocking the
proliferation of the leukemic cells by inducing cell cycle arrest and apoptosis.
Therapeutic Drug Monitoring of Voriconazole in Children with Hematologic
Malignancy and Invasive Fungal Infections: An RCT from a Tertiary Care
Centre in India
Authors: Sharad Neha , Singh Gagandeep , Xess Immaculata , Agarwal Reshu , Seth Tulika , Reeta K.H. , Kothari Sweta
Published: December 2023

Introduction:

Voriconazole is a triazole anti-fungal with non-linear kinetics and a
narrow therapeutic range. The objective of our study was to monitor the voriconazole serum levels
in children with hematological malignancy and clinically suspected invasive fungal infections.

Methods:

The study was a prospective, randomized controlled trial conducted from June 2016 to
December 2017. All children who had haematologic malignancies with clinically suspected invasive
fungal infections and received voriconazole as the only anti-fungal were included in the
study. The children were randomly allotted into two groups; one was the group that underwent
TDM, and the other, TDM, was not done. Bioassay was the method employed for TDM. The
trough levels were evaluated on a sample obtained on the fifth day of starting the drug. The institute's
ethics committee approved the study.

Result:

A total of 30 children were included in the study: 15 in the TDM group and 15 in the
non-TDM group. The most common underlying malignancy was AML. Neutropenia due to
chemotherapy sessions was these patients' most common risk factor. A favorable outcome was
seen in 13/15 (86.7%) in the TDM group and 11/15 in the non-TDM group (73.3%).

Conclusion:

Only five out of 15 (33.3%) children had voriconazole serum levels within the therapeutic
range. Alterations in dose had to be done in the remaining to achieve the recommended
serum levels. Thus, we recommend TDM for all children of hematologic malignancy receiving
voriconazole for better management. Our findings also revealed that children with AML had
lower than recommended levels of voriconazole on TDM evaluation, whereas those with ALL
had normal to elevated levels of voriconazole.
Recent Trends on Synthesis of Benzimidazoles
Authors: El-Rashedy Ahmed A. , Magd El-Din Asmaa A. , Yousif Nabil M. , Yousif Mahmoud N. M.
Published: December 2023

Preparation of benzimidazole derivatives have become the interest of many chemists because of the versatile therapeutic activity of benzimidazoles as antiulcer, antimicrobial, anti-viral, anticancer, anti-inflammatory, analgesic and anthelmintic drugs. This review will de-scribe the most recent research on benzimidazole synthesis.
Assessment of the influence of vitamin D level on the course of chronic hepatitis C in comorbidity with chronic pancreatitis
Authors: Derbak M.A. , Buchok O.V. , Ganych T.M. , Rishko O.A. , Timashev V.V.
Published: December 2023

Background. Chronic hepatitis C (СHC) is often complicated by the presence of concomitant gastrointestinal diseases, one of which is chronic pancreatitis (CP). This has a negative impact on the clinical course of both diseases, contributes to nutrient deficiencies, in particular vitamin D, and worsens the quality of life of patients. The aim of the research was to study the features of the clinical course of CHC in comorbidity with CP and to evaluate the quality of life in patients with different levels of vitamin D in blood serum. Materials and methods. The study included 120 patients who were divided into 2 groups: group 1 — 72 patients with CHC and CP and group 2 — 48 patients with CHC. In turn, patients of group 1, depending on the enzymatic activity of the pancreas, were divided into group 1a (n = 52), which included patients with CHC and CP with exocrine insufficiency (EI), and group 1b (n = 20) — patients with CHC and CP with preserved exocrine function of the pancreas. In all patients, fecal coproscopy was performed, the level of fecal elastase (FE-1), vitamin D, viral load was determined, and the degree of fibrosis and necroinflammatory activity was evaluated using FibroTest and ActiTest. Situational anxiety was assessed according to the Spielberger-Hanin method, and quality of life using the SF-12 questionnaire. The analysis and processing of the results of the examination of patients was carried out using the computer program Jamovi 2.3.2.1, Microsoft Office Excel for Windows 2016 using the Kruskal-Wallis method, the Mann-Whitney-Wilcoxon criterion and the Pearson correlation coefficient. The difference was considered to be statistically significant at p < 0.05. Results. A significantly lower level of vitamin D was found in patients of group 1a than in patients of groups 1b and 2. Patients of group 1 with higher stages of fibrosis (F2–3 and F3–4), a higher degree of necroinflammatory activity in the liver (> A2) and a high viral load have lower levels of vitamin D than those with initial stages of fibrosis and less severe necroinflammatory process in the liver. Patients with CHC, CP and exocrine insufficiency complained of mood changes, increased anxiety, rapid fatigue, and muscle weakness significantly more often than those with preserved exocrine function and patients with CHC. The level of vitamin D in people with CHC, CP and exocrine insufficiency positively correlates with the level of FE-1. In all patients with CHC in comorbidity with CP, a negative effect of low levels of vitamin D on indicators of quality of life and anxiety was found. Conclusions. A reduced level of vitamin D in the blood of patients with CHC and CP worsens the course of the disease and is associated with a decrease in quality of life.
Impairment of auditory function in persons with type 2 diabetes mellitus depending on the level of peripheral myelin protein 22
Authors: Shydlovska T.A. , Navalkivska N.Y. , Kostitska I.O.
Published: December 2023

Background. One of the priority tasks of modern medicine is early diagnosis and treatment of micro- and macrovascular complications of diabetes mellitus (DM) which cause a decrease in the quality of life of working age people and an increase in mortali­ty. Variability of carbohydrate metabolism indicators, metabolic dysfunction are leading factors in the development and progression of disabling complications of type 2 DM with hearing loss due to degenerative changes in nerve fibers. An important aspect of diagnostic and treatment algorithms of sensorineural hearing disorders in patients with type 2 DM is early detection of demyelinating processes to prevent damage to neuronal structures. The purpose of the study is to determine the relationship between the level of peripheral myelin protein 22 (PMP 22) and the condition of the auditory analyzer according to the data of instrumental examination in patients with type 2 DM combined with hearing impairment. Materials and methods. There were examined 30 patients with type 2 DM (15 men and 15 women aged 56.28 ± 4.54 years) associated with degree I–II sensorineural disorders of the auditory function; 15 people with signs of sensorineural hearing loss (SNHL) (8 men, 7 women aged 59.33 ± 2.65 years) without diabetes and 15 controls. During the examination, the patients with type 2 DM and SNHL, depending on the severity of the underlying disease, were divided into groups: the first group (n = 15) with or without isolated microvascular complications of type 2 DM, the second group (n = 15) with neuro-, nephro- and retinopathy. All patients underwent a set of laboratory tests to determine the content of PMP 22 in the blood serum, clinical and instrumental diagnosis of the auditory function. The obtained data were processed statistically, and correlations were identified. Results. The analysis of the results revealed that in patients with type 2 DM and SNHL (groups 1 and 2), the level of peripheral myelin protein 22 significantly increased compared to both controls and the comparison group, and more significantly in those with microangiopathies. The correlations were found bet­ween the most informative indicators reflecting the state of various structures of the hearing analyzer and the content of PMP 22 in the blood serum. Conclusions. A significant increase was revealed in the content of PMP 22 and manifestations of sensorineural hearing loss in patients with type 2 diabetes mellitus associated with microangiopathies that indicate demyelinating processes in the neural structures of the auditory analyzer.
An Assessment of the University Usage of Social Media Platforms: Case from Lebanon—Theoretical Foundations—Part 1
Authors: Bashir Eman , Hejase Hussin J. , Yassin Wissam , Hejase Ale J.
Published: December 2023

This paper, part of two, aims to assess how a selection of Lebanese Universities utilizes social media platforms to attract potential student candidates. Social Media is considered a significant recruitment tool universities use to attract high school graduates from the millennium digital generation. Different universities have dealt differently with social media, so capturing recorded activity is essential to assess such efforts and pinpoint gaps to justify student recruitment investments by universities. This study uses a mix of quantitative and qualitative methods. A descriptive comparative analysis is carried out based on collected data from the different university social media platforms to help categorize selected universities in their efforts, successes, and gaps. However, this paper, the first part of two, represents the theoretical foundations needed for the study. Paper part two (2) will follow to illustrate the numerical and graphical analysis. Results show a lack of motivation schemes to attract potential candidates and encourage them to interact with such platforms. Moreover, universities lack specialized digital marketing staff to produce the appropriate content and design marketing strategies that are attractive, interactive, and with high response rates to inquiries.
A RETROSPECTIVE STUDY TO ASSESS THE PREVALENCE OF DRY EYES AND DRY SKIN AMONG THE RURAL POPULATION ATTENDING OUTPATIENT DEPARTMENT AT TERTIARY CARE TEACHING HOSPITAL IN WESTERN INDIA
Authors: RATHORE KANCHAN BALA , DANGE KIRAN J. , PATIL GAURAV A.
Published: December 2023

Objective: Assess the prevalence of dry eyes and dry skin in the rural population attending OPD and determine the association between dry eyes and dry skin.
Methods: The study utilized a non-experimental descriptive analytical design with a quantitative retrospective approach. Patient records from the eye and skin OPDs at a designated tertiary teaching hospital were included in the analysis. The study period spanned from January 1, 2018, to December 31, 2022. A total of 2000 patients meeting the inclusion and exclusion criteria were included in the study. Descriptive and inferential statistics were employed to analyze the data.
Results: The prevalence rate of dry eyes was found to be 67.8%, while the prevalence rate of dry skin was 79%. There was a strong positive correlation between dry eyes and dry skin (r = 0.74, p<0.05). The study also identified a significant association between dry eyes and dry skin (χ2 = 8.34, p = 0.0038). Gender showed a significant association with dry eyes (χ2 = 4.76, p<0.05), and age showed a significant association with dry skin (χ2 = 52.57, p<0.05).
Conclusion: The study concluded that there is a higher prevalence of dry eyes and dry skin among the rural population attending OPD at tertiary teaching hospital in Western India. There is a significant positive association and correlation between dry eyes and dry skin. Gender and age were identified as demographic factors associated with dry eyes and dry skin.
Marginality in the Brontë sisters’ novels
Authors: Tine Etienne Pathé , Gning Maurice
Published: December 2023

The Brontë sisters, Charlotte, Emily, and Anne have left their mark on the literary landscape of Victorian England. Beyond the fact that they belong to the same family and are all three remarkable writers in the same period, a unique fact in literary history, these sisters fully express their genius through the sensitive and aesthetic dimension of the various themes they address in their novels. One of the major themes common to their novels is the question of marginality in a highly stratified society of 19th-century Britain. Using Marxist, new historicist, feminist, and psychoanalytical reading grids, we aim to examine this theme of marginality precisely in Jane Eyre, The Professor and Shirley by Charlotte and Wuthering Heights by Emily. This work thus reveals the multiple faces and implications of marginality in these novels in a context of economic, political and social revolution.
An Eco critical Concerns in The Living Mountain by Amitav Ghosh
Authors: Sangeeta Sangeeta
Published: December 2023

Amitav Ghosh’s The Living Mountain explores the intricate relationship between humans and the environment, particularly in the Himalayas. This eco-critical analysis unravels ecological concerns in Ghosh’s narrative, emphasizing the interplay between nature and human existence. Examining Ghosh’s literary techniques, the research highlights how the novel serves as a tool for ecological consciousness, using character interactions, natural landscapes, and indigenous knowledge. The analysis explores implications of Ghosh’s choices, including the portrayal of local communities, climate change impact, and the symbiotic relationship between humanity and nature. Through this lens, the paper sheds light on eco-critical concerns, contributing to contemporary environmental discourse and emphasizing the need for collective commitment to sustainability and harmonious coexistence.
Probiotic Properties and Anti-inflammatory Activity of Bacillus spp. Isolated from Ethnically Fermented Soybean
Authors: Khongriah Welfareson , Maurya Ruchika , Kondepudi Kanthi Kiran , Joshi Santa Ram
Published: December 2023

Bacillus spp. probiotics used as feed additives can form spores and tolerate the harsh conditions of the human digestive system and are beneficial for the treatment of inflammatory bowel syndrome. Since reports on probiotics and anti-inflammatory properties of Bacillus spp. isolated from the fermented food of Northeast India have not been explored much. The present study focused on Bacillus spp. BN5, AY5, and AN8, possessing these desired properties. In the probiotics study, the isolates were screened for their tolerance to acid and bile salt, auto-aggregation, hydrophobicity, cholesterol assimilation, antibiotic resistance, and antagonistic properties. It was found that these isolates possessed the desirable probiotic traits. The Bacillus spp. culture and their supernatant were also screened for their ability to reduce LPS-induced inflammation in murine macrophage (RAW 264.7) cells. All the Bacillus spp. culture and their supernatant treatments were found to reduced the Nitric oxide (NO) production by LPS-induced cell lines. The supernatant of LPS-induced cell lines were also analyzed to measure the level of inflammatory cytokine production. It was found that the levels of TNF-α, IL-6, and IL-1β were reduced after co-treatment with LPS and Bacillus spp. culture or LPS and Bacillus spp. supernatant. Results suggested that the Bacillus spp. are potential probiotic candidates with anti-inflammatory properties.
Antibiotic-resistant Escherichia coli Undergoes a Change in mcr-1 and qnr-S Expression after being Exposed to Gamma Irradiation
Authors: Merdash Ahmed G. , El-Sherbiny Gamal M. , El-Gendy Ahmed O. , Azmy Ahmed F. , El-Kabbany Hussein M. , Ahmad Maged S.
Published: December 2023

Human consumption of antibiotics has increased their concentrations in many parts of the environment, including rivers, sediments, soil, and wastewater. Consequently, resistant bacteria originating from these environments are distributed to humans, resulting in illness. The aim of this study was to identify mobilized colistin-resistant (mcr) genes and quinolone-resistant (qnr) genes in E. coli strains obtained from clinical samples. Additionally, the study explored the impact of different radiation dosages on the expression of antibiotic-resistance genes. In this study, conducted in Beni-Suef, Egypt, samples from 430 community-acquired urinary tract infection (UTI) cases resulted in the isolation of 85 different strains of E. coli. Conventional microbiological procedures were employed to identify these bacterial isolates. Three bacterial isolates with resistance to both quinolones and colistin underwent examination for their corresponding genetic determinants, which subsequently proved the presence of their respective genes. Furthermore, the expression levels of the mcr-1 and qnr-S genes were assessed using real-time PCR after exposure to gamma irradiation. Remarkably, the use of a sublethal dosage of 3 kGy gamma irradiation treatment on bacterial cells increased their susceptibility to colistin and quinolones post-irradiation. Additionally, there was a notable reduction in the expression levels of both mcr-1 and qnr-S genes, which could be helpful for preventing the storage of antibiotic-resistant E. coli in the environment.
State of the Art - Cybercrimes and Cyber Security Policies and Countermeasures
Authors: A. K. R. S. Anusha
Published: December 2023

Abstract: The world has become a global village because of the availability of Internet Connectivity and mobile devices to most of the masses around the world. The benefits of digitalization goes hand in hand with a steep rise in cybercrimes, cyber threats and cyberattacks. Cyber security has become crucial in our day to day life in order to protect our information systems. Cyber security has become a buzz word and has kindled interests among cyber security experts, researchers, academicians, private organizations and the government alike. This paper explores the state of the art in Cyber Security and the challenges caused by cybercrimes, cyber threats and cyberattacks. Various methods to protect individuals, organizations, and governments from cybercrimes has been addressed in this paper. Importantly, ways to detect and report cybercrimes are also dealt with.
Persepsi Tamu Terhadap Kinerja Karyawan Restoran
Authors: Dwipayana Ida Bagus Made Aditya Ananta , Ismail Deden , Aprinica Ni Putu Isha
Published: December 2023

Penelitian ini dilakukan untuk mengetahui persepsi tamu terhadap kinerja karyawan berdasarkan 5 indikator (Tangible, Reliability, Responsiveness, Assurance, dan Empathy) dan mengetahui indicator apa saja yang menjadi prioritas bagi pelanggan yang berkunjung ke Rollpin Casual Smart Dine Mataram – Lombok melalui diagram kartesius. Teknik pengumpulan data yang digunakan dalam penelitian ini adalah dengan menggunakan kuesioner. Berdasarkan hadil olah kuesioner yang peneliti ajukan ke 32 responden dan kuesioner menunjukan bahwa tingkat harapan tamu terhadap kinerja karyawan berdasarkan 5 indikator masih lebih besar dari pada tingkat kenyataan di lapangan. Dan berdasarkan hasil yang didapat dari diagram kartesius indikator empathy merupakan indikator yang menjadi prioritas bagi tamu namun pelaksanaanya perlu ditekankan lagi. Indikator reliability merupakan indikator yang dianggap kurang penting bagi tamu namun pelaksanaanya dianggap cukup, sedangkan indikator tangible, assurance, dan responsiveness dianggap tidak terlalu penting akan tetapi pelaksanaannya tergolong sangat baik.
 
This research was conducted to determine guest perceptions of employee performance based on 5 indicators (Tangible, Reliability, Responsiveness, Assurance, and Empathy) and find out what indicators are priorities for customers who visit Rollpin Casual Smart Dine Mataram – Lombok via Cartesian diagram. Data collection techniques used in this research is to use a questionnaire. Based on processing results questionnaire that the researcher submitted to 32 respondents and the questionnaire showed that the level of hope guests on employee performance based on 5 indicators is still greater than the level reality on the ground. And based on the results obtained from the Cartesian diagram of empathy indicators is an indicator that is a priority for guests, but its implementation needs to be emphasized again. The reliability indicator is an indicator that is considered less important for guests however implementation is considered sufficient, while the indicators are tangible, assurance and responsiveness considered not very important, but its implementation is considered very good.
Caracterización de la evasión fiscal en establecimientos gastronómicos de Bogotá
Authors:   Universidad Piloto de Colombia, Colombia, Briñez Torres Carlos Yesid , Gutiérrez Duarte Carlos Eduardo ,   Universidad Católica de Colombia, Bogotá, Colombia
Published: December 2023

La identificación de la evasión y elusión fiscal en el caso de los comercios no formales es una necesidad urgente para alcanzar los objetivos de desarrollo sostenible en Colombia. El presente estudio tiene como objetivo realizar un seguimiento a los procesos de formalización en el sector de establecimientos gastronómicos de una zona de Bogotá y calcular, a partir de una metodología observacional de cliente incógnito, los ingresos presuntos y la posible evasión del impuesto al consumo. De 68 comercios informales identificados en dos barrios de la localidad de Chapinero en Bogotá, se seleccionaron de manera aleatoria 15 restaurantes y se llevó a cabo un seguimiento por cinco días, registrando las ventas, las sillas y la existencia o no de factura. Este procedimiento se repitió en los mismos restaurantes en el 2021 y 2022. Los resultados mostraron una presunta y significativa evasión del impuesto al consumo, en la medida que durante los dos años de observación no se realizaron cambios de régimen y no se detectó la existencia de facturas de venta, incluyendo el impuesto al consumo. Se discuten los aportes de la metodología de observación sistemática a la prevención de la evasión y la elusión, como también las posibles acciones para mejorar la tributación en el sector gastronómico.
Salario policial, análisis comparativo de las brechas existentes entre los estipendios del sector público
Authors:   Policía Nacional de Colombia, Bogotá Colombia, Flórez Rincón Oleskyenio Enrique , Medina Carrión Óscar Fernando ,   Policía Nacional de Colombia, Bogotá Colombia, Sanabria Wilson Alexander ,   Policía Nacional de Colombia, Bogotá Colombia, Cortés Olarte Gonzalo Andrés ,   Policía Nacional de Colombia, Bogotá Colombia, Echeverri Petti Luce Marina ,   Policía Nacional de Colombia, Bogotá Colombia
Published: December 2023

Este artículo de revisión presenta una comparación teórica de la realidad salarial policial, frente a los estipendios de 16 entidades del Estado en materia ocupacional y 14 a nivel nominal, analizados bajo los criterios de homogeneidad-diferencia, desde un enfoque cualitativo con carácter descriptivo. A partir de la triangulación de datos provenientes de diferentes fuentes, se intenta mostrar al lector distintos escenarios en materia organizacional y su relación con los regímenes legal, salarial, prestacional, de funciones y competencias. Para tal fin, se realiza un análisis de contexto, que tiene por objetivo general, alinear las etapas de identificación de similitudes y disimilitudes relacionadas con estructuras jerárquicas, niveles de riesgo, política remunerativa y marco jurídico que les definen, logrando identificar las brechas existentes entre los estipendios del sector público y la Policía Nacional de Colombia.
Caracterización de los caninos en función de vigilancia y seguridad privada. Contribución para la prevención y seguridad en Colombia
Authors:   Policía Nacional, Bogotá, Colombia, Bohórquez Gabriel Antonio , Gutiérrez Guauta David Orlando ,   Policía Nacional, Bogotá, Colombia, Aparicio Barrera Juan ,   Policía Nacional, Bogotá, Colombia
Published: December 2023

La utilización de caninos es habitual tanto en la seguridad pública como en el servicio de vigilancia privada. En Colombia, la Policía Nacional certifica a los caninos para que puedan ser utilizados para la seguridad privada. El presente artículo muestra cuál es el comportamiento de las variables de especialidad, sexo y raza de 1949 perros certificados, pertenecientes a 56 empresas de la seguridad privada y que pasaron por el proceso de certificación por parte de la Policía Nacional durante el último trimestre de 2022 y primero de 2023. El estudio es un análisis descriptivo de los registros administrativos de la Escuela de Guías y Adiestramiento Canino, perteneciente a la Dirección de Educación Policial, según el Formato de Evaluación para Certificación Caninos a Empresas de Vigilancia y Seguridad Privada. De tal forma, según la especialidad, el 36% de los perros se emplean para la defensa controlada, el 41.5% para la detección de explosivos y el 22.5% para la detección de narcóticos. En cuanto al sexo, el 63.2% son machos y el 36.8% hembras; y respecto a la raza, el 26.6% son labrador retriever, el 20% rottweiler, el 18.8% golden retriever, el 18% pastor alemán y el 13.6% pastores belgas malinois. De esta manera, las organizaciones de vigilancia privada incluyen entre sus servicios el uso de caninos y para satisfacer la demanda han seleccionado ciertas razas para desempeñarse en escenarios que representan vulnerabilidad a la seguridad por cuenta de las manifestaciones delictivas.
Redes Sociales: Riesgos y desafíos para la comunidad académica de los colegios de la Policía
Authors:   Policía Nacional, Bogotá, Colombia, Villa Ramírez José Neftalí , Mesa Méndez Carlos Manuel ,   Policía Nacional, Bogotá, Colombia, Garzón Santos José Luis ,   Policía Nacional, Bogotá, Colombia, Urueña Sanabria Rut ,   Escuela de Cadetes de Policía, General Francisco de Paula Santander, Bogotá, Colombia
Published: December 2023

La utilización de redes sociales por los estudiantes de educación media de los colegios de la Policía Nacional en Bogotá, incluye, la identificación de posibles vacíos en temas de ciberseguridad, pese a programas y estrategias relacionadas con el uso responsable al navegar por el ciberespacio. Esta investigación se sustenta en el paradigma comprensivo-interpretativo (sociológico) con un enfoque mixto de preponderancia cualitativa. Se realizó una revisión documental, encuesta a estudiantes y entrevista en profundidad a padres de familia y docentes. Se agruparon los hallazgos en dos categorías; ciberseguridad y educación. Los resultados de la encuesta evidenciaron una hiper- conectividad por parte de los estudiantes; la interacción realizada a través de las redes sociales, especialmente mediante el intercambio de fotos, videos, compartir estados y hacer video llamadas. Los hallazgos de la entrevista expresan que, si bien cada establecimiento educativo es autónomo, no es claro entre padres de familia, cuidadores y docentes una ruta expresamente definida a seguir al momento de evidenciar peligros emergentes al uso evidenciado en redes sociales. También falta mayor corresponsabilidad al identificar ciertos tipos de conductas que atentan contra los estudiantes, dado que algunos padres consideran que es un tema del cual debe encargarse el colegio, mientras que los docentes discurren que es compromiso de los padres. En conclusión, se deja al descubierto, la necesidad de valorar el grado de aceptación, efectividad y alcance de estrategias desarrolladas por colegios y entes privados o gubernamentales, respecto a la sensibilización en temas de ciberseguridad y uso responsable al navegar en internet.
Relatos de jóvenes urbano-popular frente a la segregación socio-territorial
Authors:   Universidad Católica de Temuco, Vivero Arriagada Luis Alberto
Published: December 2023

Se presentan parte de los resultados de una investigación de carácter cualitativa, cuyo objetivo fue comprender la segregación socio-territorial y la desigualdad estructural, desde la perspectiva de los jóvenes urbano-populares del sector portal San Francisco de la ciudad de Temuco. Con una metodología de carácter cualitativo, se utilizó el grupo de discusión con jóvenes de 15 a 29 años, como técnica de recolección de información. Se recogieron los relatos y experiencias de jóvenes y a partir de ello se generaron categorías de análisis en función de los objetivos. Se concluye que la segregación socio- territorial es una expresión material que determina las subjetividades de estos jóvenes, y sus prácticas cotidianas.
Diasporas mediju pētījums
Authors:   Latvijas Universitāte, Ločmele Klinta , Uzule Laura
Published: December 2023

Šis ir pirmais apjomīgais pētījums pēdējo gadu laikā, kurā analizēts diasporas mediju saturs un pašu mediju redzējums par medija lomu, darbību un nākotnes prognozēm. Pētījuma mērķis: noskaidrot Latvijas diasporas mediju veidus un piedāvāt Latvijas situācijai atbilstošu definīciju un diasporas medija statusa kritērijus, izpētīt valsts iestāžu gaidas no tiem un pašu mediju redzējumu par savu darbību, finansējumu, žurnālistikas ētiku, auditoriju un to pastāvēšanas riskiem, diasporas mediju darbības izbeigšanas iemeslus, analizēt diasporas mediju saturu tematiskajā un žurnālistikas kvalitātes ziņā, pievēršot šiem jautājumiem uzmanību arī no Mediju atbalsta fonda saņemtā finansējuma kontekstā. Pētījuma jautājumi: Kāda ir Latvijas gadījumam piemērojama diasporas medija definīcija, un kādi Latvijas diasporas mediji pastāv? Kāds bija oriģinālsatura īpatsvars, un kādā kvalitātē tas tika veidots diasporas medijos 2022. gadā? Vai un kādas ir atšķirības satura kvalitātē, kas radīts ar un bez Mediju atbalsta fonda finansējuma? Kādi šobrīd ir Latvijas īstenotie diasporas mediju atbalsta mehānismi, un kas no diasporas medijiem tiek sagaidīts? Kādu iemeslu dēļ pēdējos astoņos gados (kopš 2014. gada pētījuma) ir beiguši pastāvēt daļa diasporas mediju un interneta vietņu? Kā tiek nodrošināta diasporas mediju ikdienas darbība, tostarp žurnālistu ētikas ievērošana un finansējuma piesaiste, un kā diasporas mediju pārstāvji redz lielākos pastāvēšanas riskus? Kā diasporas mediju pārstāvji redz savu auditoriju, misiju un kādu atbalstu sagaida no Latvijas valsts?
Legal realities of the Golden Horde Crimea through the eyes of foreign contemporaries
Authors:   National Research University Higher School of Economics in St. Petersburg, Pochekaev Roman Yu. ,   “The Great Altai” Scientific Educational Center of altaistics and turkology of the Altai State University
Published: December 2023

The article is an analysis of specific status of the Crimea as a part of the Golden Horde and as it was reflected in the contemporary sources: notes of travelers, diplomats, merchants, missionaries, etc., correspondence of rulers, historical chronicles and hagiographic works based the information of eye-witnesses. Despite of the fact that the Crimean Peninsula was an integral part of the Golden Horde, its specific position, including the structure of population, international trade relations and the interest of the foreign states, caused the series of specific features in the legal regulations of different groups of inhabitants. The system of authorities in Crimea, taking into account the position of some cities (such as Sudak or Caffa), is observed as well as religious policy of khans towards different confessions, specific taxes and duties. The author finds out that although the Crimean Peninsula was completely in the field of the Golden Horde political and legal regulations, khans needed to take into consideration its strategic position, national and confessional structure of the population and these peculiarities were reflected in the Crimean legal realities.
Literary and cultural character of Cemil Seitabla Kermenchikli (1891–1942) (part 2)
Authors:   Fevzi Yakubov Crimean Engineering and Pedagogical University, Kerimov Ismail A. ,   Marjani Institute of History of the Tatarstan Academy of Sciences
Published: December 2023

Cemil Kermenchikli is one of the brightest Crimean Tatar poets of the early twentieth century, who played a significant role in the development of the national poetic word in the Crimea. On the basis of new materials recently discovered both in the central and in the repositories of regional libraries in Russia, the article reveals new facets of his work and introduces many clarifications into the development of the author’s scientific biography. Attention is paid to the rich journalistic component of his work. The appendix to the article contains unknown poetic works of the author relating to the period of the First World War.
A memory state-feedback controller via random pocket dropouts for multi-agent systems with external disturbance
Authors: Thipcha J. , Stephen A. , Srinidhi A. , Raja R. , Kaewbanjak N. , Mukdasai K. , Singkibud P. , Yotha N.
Published: December 2023

This study explores the challenge of achieving consensus in multi-agent systems (MASs) when facing the random packet dropouts and disturbances. It employs memory state-feedback control (MSFC) in the context of undirected graphs and specified leader agents. The analysis focuses on mean square consensus, considering MASs within strongly connected networks or networks with undirected spanning trees. The MSFC approach is developed to ensure asymptotic consensus despite packet dropouts and also to reduce the impact of disturbances. Specifically, the consensus analysis leverages the Lyapunov-Krasovskii functional (LKF) framework, and the necessary conditions for implementing the proposed MSFC are established using linear matrix inequalities (LMIs). The system, augmented with an H ∞ attenuation level is guaranteed to achieve asymptotic mean-square stability according to the provided criteria. In conclusion, two examples are provided to illustrate the effectiveness and practicality of the proposed control mechanism.
A Case Study in Attachment Trauma Counseling: Focusing on the Integrative Applicability of Eye Movement Desensitization Reprocessing(EMDR) and Internal Family Systems(IFS) Therapy
Authors:   Korean Association of Christian Counseling & Psychology, Shin Sujeong
Published: December 2023

The purpose of this study is to present an integrative counseling approach to support the recovery of attachment trauma clients, focusing on the process of creating a sense of safety and building resources to help clients connect with the power of their authentic inner self. This paper examines an integrative counseling approach to help clients recover from attachment trauma by combining the Eye Movement Desensitization and Reprocessing(EMDR) technique with the counseling techniques of the Internal Family System(IFS) therapy. In addition, we examined the integrative counseling approach and the process of recovery through the case of a woman in her 20s who experienced attachment trauma, in order to contribute to providing the best counseling for attachment trauma clients. Based on the results of this study, limitations, implications, and further research are discussed.
O CARNAVAL DE CLUBES DE RIO NOVO
Authors: Xavier Felipe Araújo
Published: December 2023

Esse texto tem como objetivo apresentar a história do carnaval de clubes de Rio Novo – MG, entre 1907 e 1979, período no qual a sociedade rionovense foi marcada por forte segregação socioeconômica e racial, utilizando como fonte principal a memória dos foliões rionovenses.
Tugas Guru dalam Perspektif al-Qur`an Surat al-Jumu’ah Ayat 2
Authors: Muslimin Minal , M Afrizal.
Published: December 2023

This study aims to find out lesson contained in surah al-Jumu’ah verse 2 and to explore the existence of the teachers’ responsibilities in surah al-Jumu’ah verse 2. This is a library research in which the research activities are carried out by collecting data from various literatures that include books in libraries, documents, and others. The findings of this study show that the teachers’ responsibilities are similar to the duties of the prophets and apostles. Therefore the best way to be used by a teacher is to model and imitate what had been taught by the Prophet to his students (friends) in guiding, directing, advising, with the main duty is to always teach the Quran to the students to make them calm down and soften their soul in accepting lessons, cleanse their souls from the misguided understanding of ‘aqidah and the despicable nature leading to fitrah, noble character and purity of heart, teach the contents of the Quran, hadith, and science (wisdom) universally.
Menggagas Era Baru Pendidikan Islam 4.0 yang Visoner
Authors: Bahri Samsul
Published: December 2023

This paper discusses the idea of a new era of visionary Islamic education 4.0, this study is a philosophical normative, and philosophical, substantial approach. The method used is analytical descriptive supported by authoritative sources. This study offers an offer on Islamic education to get out of the problems of Islamic education that occur in its implementation, both the dichotomy of science, exclusivism, and only in the form of teaching that does not teach students. So this paper proves the importance of a new era of Islamic education that follows the 4.0 industrial revolution by participating in self-discipline by creating non-dichotomic education, inclusivism, and changing from teaching to learning, with a digital basis so that Islamic education is able to develop its potential, and learn to complete all life problems or with the term learning how to learn.
RELEVANSI NILAI-NILAI KEWIRAUSAHAAN DALAM MATERI PAI BP SMA SEDERAJAT K13 REVISI 2020
Authors: Adib Hamdan , Suriyah Suriyah , Fatimah Siregar Siti
Published: December 2023

The purpose of this research is to find out the relevance of entrepreneurship values in the PAI BP material at SMA Sederajat K13 Revised 2020. This study uses a qualitative method in the type of literature study. The primary source in this research is LKS PAI BP SMA and secondary sources are various literatures that support the research theme. The results of this study indicate that there is a relevance of entrepreneurial values in the PAI BP material in SMA including in class X material, Chapter 3 explains the obligation to study where entrepreneurs must have broad insight, then class XI in Chapter 1 is a work ethic material that has a work orientation. and later results in Chapter 10 related to Islamic economics and various economic practices based on the rules of the Qur'an Hadith and other Islamic legal bases and class XII in Chapter 1 and Chapter 4 which discusses positive thinking, hard work and responsibility is a form of concrete of the leadership values contained in entrepreneurship.
Pengaruh Penerapan Strategi Inkuiri dan Penggunaan Media Power Point terhadap Kreativitas Belajar Siswa pada Pelajaran Pendidikan Agama Islam
Authors: Hidayat Muhammad
Published: December 2023

This study aims to see whether there is an influence of the Implementation of the Inkuri Strategy and the Use of Power Point Media on Student Learning Creativity in PAI Lessons in Private Vocational Schools in the Bukit Raya District of Pekanbaru City. The population in this study were all private vocational students in the Bukit Raya District of Pekanbaru, totaling 1,012 people. The sample in this study was taken by probality random sampling technique with 5% of the total pollution that is 290 people. Data collection was performed using a questionnaire technique (questionnaire), the data collected was analyzed using multiple regression analysis namely Y = a + b1X1 + b2 X2. The results of this study indicate the value of R2 (coefficient of determination) or R Square of 0.343 or 34.3%. This value can be interpreted that changes in student learning creativity by changing the value of the independent variable application of inquiry strategy and the use of power point media by 34.3% while 56.7% is determined by changes in other factors. The tcount for the implementation of the inquiry strategy variable was 7.856 with sig. 0,000 is smaller than 0.05, this means that there is an influence of the application of inquiry strategy on student learning creativity and the tcount for the variable use of power point media is 4.742 with sig. 0,000 is less than 0.05 which means there is an influence of the use of power point media on student learning creativity. It can be concluded that there is an influence between the application of inquiry strategy and the use of power point media on the creativity of student learning in PAI lessons in Private Vocational Schools in the Bukit Raya District of Pekanbaru City
Implementasi Kebijakan Kurikulum Kondisi Khusus Pandemi Covid-19 Pada Pembelajaran Pendidikan Agama Islam Di SMA Negeri 1 Bangkinang Kota
Authors: Farih Imam , Ramli Ramli
Published: December 2023

Tujuan penelitian untuk mengetahui implementasi kurikulum kondisi khusus pada pembelajaran Pendidikan Agama Islam di SMA Negeri 1 Bangkinang Kota, Faktor pendukung dan penghambat, dan solusi yang diambil apabila didapati faktor penghambat. Penelitian ini menggunakan pendekatan kualitatif, tehnik pengumpulan data yang digunakan adalah wawancara, observasi dan dokumentasi. Analisis data menggunakan analisis deskriptif yang menggunakan metode mereduksi data, menganalisa data, dan menarik kesimpulan. Hasil penelitian ini menunjukkan bahwa Implementasi kurikulum yang digunakan di SMA Negeri 1 Bangkinang Kota adalah kurikulum darurat dengan kompetensi inti dan kompetensi dasar yang disederhanakan untuk Kondisi Khusus. Guru membuat perencanaan pembelajaran dengan mengacu kepada kurikulum darurat, pembelajaran dilaksanakan dengan cara pembelajaran jarak jauh (daring), terdapat faktor pendukung yakni sarana dan prasarana yang memadai, dan faktor penghambat adalah kemampuan guru dalam melaksanakan pembelajaran berbasis didgital, solusi yang diambil adalah melakukan pelatihan guru dalam hal pembelajaran berbasis digital.TRANSLATE with x EnglishArabicHebrewPolishBulgarianHindiPortugueseCatalanHmong DawRomanianChinese SimplifiedHungarianRussianChinese TraditionalIndonesianSlovakCzechItalianSlovenianDanishJapaneseSpanishDutchKlingonSwedishEnglishKoreanThaiEstonianLatvianTurkishFinnishLithuanianUkrainianFrenchMalayUrduGermanMalteseVietnameseGreekNorwegianWelshHaitian CreolePersian //  TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster PortalBack//