bluuebunny/crossref_metadata_2025 huggingface dataset:
The Effect of Growth Regulator Substance and Growing Media on The Growth of Shoot Cuting Coffea arabica L.
Authors: Hani Aditya , Amalia Muhyidin Riskyia
Published: February 2021

Coffee can be propagated vegetatively, namely by cuttings. One of the factors that can affect the success of coffee cuttings is the use of growth regulators (ZPT) and the right type of planting medium. This study aims to determine the concentration of growth regulators and the type of planting medium that gives the best growth in Arabica coffee cuttings (Coffea arabica L.). The research was conducted at the nursery of the Agroforestry Research and Development Center in Cijeungjing, Ciamis Regency. The experiment was conducted from August to November 2019. The experiment used a factorial randomized block design (RBD) consisting of two factors. The main factors were planting media: cocopeat, husk charcoal, soil; the second factor was the concentration of auxin regulators with active ingredients (active ingredients: naphthalene acetic and naphthalene acetic amid): 0 ppm, 1,000 ppm, 2,000 ppm, 3,000 ppm. The results showed that the interaction between the treatment of planting media and the provision of growth regulators only gave a significant difference in the number of secondary root parameters. The single factor effect of ZPT dose did not provide significant differences in each parameter. Single factor of soil media resulted in significant differences in the parameters of the percentage of root cuttings, root dry weight and percentage of live cuttings. Based on the results of this study, the use of soil growing media resulted in the best percentage of cuttings compared to other growing media.
StandingTrees Volume Tape of Teak to Support The Management of Private Forest Budiman Achmad, Dian Diniyati
Authors: Achmad Budiman , Diniyati Dian
Published: February 2021

The absence of an estimating tool for the volume of standing trees causes the community timber management to tend to disadvantage farmers. This study aims to provide a practical tool for estimating the volume of teak trees in an equitable timber transaction. This research used samples of 74 Nusantara Superior Teak (JUN) stands in Lemahbang Village, Bendo District, Magetan Regency, East Java, representing the smallest to largest diameter classes. The data were collected using a destructive method by felling trees and bucking them into logs at most 2 m long. The total volume of trees is obtained by summing up all the logs till the smallest diameter of 7 cm. Data were analyzed using linear regression V = a + b*DBH and non-linear V = a*DBHb. The results showed that the teak tree volume tape was better constructed using a non-linear model V = 0.0000776 DBH2.613 with r = 0.94. This teak tree volume tape can help minimize the gap in tree volume estimation between farmers and intermediaries. Besides, this volume tape can also reduce damage to other crops, minimize plant biodiversity loss, and maintain environmental quality because tree sales will tend to be selective, not clear-cut. It is also important to support the implementation of available trade by providing regulation by the local government.
EFEK INTERAKSI MASA EKUILIBRASI DAN LAJU PENURUNAN SUHU TERHADAP PENINGKATAN KEUTUHAN MEMBRAN PLASMA SPERMA DOMBA PRIANGAN PASCA THAWING (The Interaction Effect of Equilibration Time and Freezing Rate toward the Membran Plasma Sperm Integrity of Priangan Ram Sperm Post thawing)
Authors: Alhuur Ken Ratu Gharizah , Soeparna Soeparna , Darodjah Rd. S.
Published: February 2021

In general, the freezing process of semen will have a detrimental effect on the structure and function of spermatozoa. The critical point in the semen freezing process is when the temperature drops to freezing, but this can be overcome by applying the right equilibration period. This study aimed to find out the best the equilibration length, the freezing rate,  their interaction in the semen freezing process towards membrane sperm cell integrity of the frozen semen post thawing. This study used Priangan sheep’s semen and was carried out according to a completely randomized design with a 3 x 3 split-plot design arrangement. The main plot was equilibration length, i.e., 0.5,  1.5, and 2.5 hours. The subplot was the freezing rate, i.e., 7.5ºC/mins, 13.5ºC/mins, and 19.5ºC/mins. The result of the study showed that there was a significant interaction (P<0.05) between the equilibration length of 1.5 hours and the freezing rate of 13.5°C/mins on the motility and the membrane sperm cell integrity. In conclusion, the best sperm quality was obtained from the equilibration length of 1.5 hours and the freezing rate of 13.5°C/mins.
STUDI KELAYAKAN TRAINER JARINGAN KOMPUTER SEBAGAI MEDIA BELAJAR PADA PRAKTIKUM JARINGAN KOMPUTER DASAR
Authors: Pratiwi Agustina Dyah , Hatta Puspanda , Efendi Agus
Published: February 2021

Jaringan komputer merupakan mata kuliah yang umum terdapat dalam kurikulum pendidikan tingi bidang teknologi informasi. Pada mata kuliah jaringan komputer, mahasiswa dituntut memiliki kompetensi dalam mengoperasikan perangkat keras jaringan komputer. Pada umumnya, pembelajaran praktik untuk melatih ketrampilan motorik pada jaringan komputer selama ini hanya menggunakan software simulasi. Pada umumnya, mahasiswa belum memiliki ketrampilan dalam mengoperasikan perangkat jaringan secara langsung pada tingkat dasar ini. Pada penelitian ini dibuat sebuah media belajar praktik untuk jaringan komputer dasar dalam bentuk perangkat keras trainer. Trainer tersebut digunakan sebagai media belajar praktik untuk mengoperasikan network device secara nyata. Penelitian ini juga bertujuan untuk menguji tingkat kelayakan trainer jaringan komputer ketika digunakan dalam perkuliahan. Model pengembangan yang digunakan untuk membuat trainer ini menggunakan model pengembangan Alessi dan Trollip. Hasil validasi dari ahli media dari segi kelayakan perangkat media belajar menunjukkan tingkat kelayakan trainer ini sebagai media belajar praktikum sebesar 80,7%. Sedangkan hasil validasi dari praktisi jaringan komputer menunjukkan bahwa tingkat kelayakan materi trainer jaringan ini sebesar 89,4% jika digunakan sebagai suplemen untuk pembelajaran jaringan komputer dasar.
Inteligência artificial incorporada à Administração Pública: mitos e desafios teóricos
Authors: Lírio do Valle Vanice
Published: February 2021

A disseminação de inteligência artificial através de quase todas as áreas da vida ordinária, mais cedo ou mais tarde vai alcançar à Administração Pública, apoiada por promessas de celeridade, acuidade e outros benefícios no que toca às decisões do Estado Administrativo. Este artigo, construído a partir do método crítico-dialético, oferece um leque de conceitos sobre modelagem de inteligência artificial, e as funções que ela pode desempenhar em organizações públicas. Também mapeia pontos de tensão iniciais que o uso de inteligência artificial pode trazer às organizações públicas, quando adotada sem uma perspectiva crítica. A conclusão é pela necessidade urgente de revisitação de velhos cânons do Direito Administrativo, vez que eles podem não se revelar úteis, no seu conteúdo tradicional, a prevenir abuso de poder em cenário onde inteligência artificial decide, ou quando menos, induz decisões.
O consequencialismo e a LINDB: a cientificidade das previsões quanto às consequências práticas das decisões
Authors: Gabardo Emerson , De Souza Pablo Ademir
Published: February 2021

O presente trabalho tem como ponto de partida a existência de problemas hermenêuticos que seriam causados pela prevalência do modelo de fundamentação focado em princípios no Direito brasileiro. A resposta comumente oferecida é a alteração de paradigma, rumo ao pragmatismo. O objetivo é discutir a problemática da aplicação do art. 20 da Lei de Introdução às Normas do Direito Brasileiro a partir das teorias consequencialistas da decisão judicial, especialmente no que tange à cientificidade da previsão quanto às prováveis consequências apontadas pelos julgadores. O método utilizado foi o descritivo, a partir de análise bibliográfica direta. A partir do debate sobre o consequencialismo enquanto teoria da decisão judicial, foi possível traçar um panorama sobre alguns problemas relativos à aplicabilidade do art. 20 da LINDB. Um deles se refere à questão da cientificidade das previsões utilizadas como fundamento das decisões, ou, em outros termos, o problema da validade da etapa descritiva do consequencialismo. O primeiro problema refere-se às questões temporais e financeiras que a encomenda de estudos técnicos específicos para cada caso pode acarretar à realidade dos tribunais. O segundo problema trabalha o cenário hipotético ideal, no qual todas as decisões são lastreadas com estudos técnicos e pareceres realizados com o maior rigor metodológico possível. No entanto, mesmo neste cenário, as previsões lastreadas por estudos, pareceres e decisões se limitariam a descrever juízos probabilísticos sobre a realidade – podendo implicar subjetivação do processo e deturpações do resultado. A revolução científica operada através dos métodos quantitativos alterou a percepção sobre a verdade buscada através da ciência. Deixou-se a busca das verdades determinísticas em detrimento das verdades probabilísticas. Todavia, a ausência de lastro probatório adequado para as previsões pode relegar o argumento consequencialista ao senso intuitivo dos operadores que, por sua própria natureza, não possuem habilitação sobre outras áreas do conhecimento. Ao final, toda esta conjuntura pode favorecer a impactação de fenômenos como o lawfare, o populismo judicial e o moralismo político na decisão dos administradores, controladores e juízes – o que caminha em sentido inverso à ideia original de busca por uma solução aos problemas hermenêuticos do Direito brasileiro neste início do século XXI.
Multidimensional Signal Analysis as a Means of Better Understanding Factors Associated with Repetitive Use in Violin Performance
Authors: Shan Gongbing , Visentin Peter , Schultz Arlan
Published: February 2021

Multidimensional signal analysis (MSA) involves the coordination and correlation of data gathered by multiple analytic techniques. For complex biosystems, MSA provides a means to investigate better aspects of the system that cannot be understood easily using a single method. This is
clearly the case for repetitive use injuries, also commonly referred to as overuse syndrome. Injuries from overuse syndrome are the result of deliberate physical behaviors. They typically are investigated through injury-site examinations, statistical or epidemiologic studies, and observation
of the behaviors associated with the injury. Diverse methods often must be used to evaluate a patient because individually they provide only partial information relating to the etiology. The use of MSA permits the integration of multiple observational perspectives, generally creating a more
holistic view. Using MSA, accurate external description of the movements thought to cause injury can be linked with internal physiologic conditions. Because physical work causes observed damage in overuse syndrome patients, a full examination of internal loading and muscle activity provides
one possibility for understanding the evolutionary nature of these pathologies. Kinematic description, internal load analysis, electromyography, and biomechanical modeling are complementary methods used for MSA in this study. In the current study, a nine-camera ViCON v8i system was used to
capture three-dimensional body kinematics as input for inverse dynamic modeling. Electromyography (Noraxon; 8-channel, wireless) was measured and synchronized to the model, permitting the correlation of joint moments and selected muscle activity. Results reveal clear relationships between
muscle activity and physiologic loading for a variety of bowing speeds, strong interaction among muscles and groups of muscles, and changes in motor control at varying speeds. Additionally, load levels and work patterns are quantitatively established, and evidence is found to support a three-phase
division of motor control based on speed: (1) increasing physical effort, (2) optimization, and (3) approaching physiologic limits. Combined with previous kinematic, kinetic, and statistical studies, the current study illuminates the relative risks of static versus dynamic loading, and provides
perspective on the working patterns of muscles throughout the kinematic chain of the arms and torso during violin performance. Most importantly, this study begins the process of establishing MSA as a means of gleaning a greater overall view from the separate observational perspectives provided
by multiple assessment methods used to examine performing artists’ injuries. This is the first such study for violin performance; an activity highly correlated with overuse syndrome.
Competition in the Arts: Risks and Benefits?
Authors: Brandfonbrener Alice G
Published: February 2021

One problem in writing editorials for Medical Problems of Performing Artists is a consequence of the need to complete them in advance of publication. What is deemed currently important as I write is often both stale and irrelevant 4 months later. Thus, if I write about what is of interest
now in August, the Athens Olympics, this does not ensure that it will be particularly timely when it is read in December. However, in August, I also re-read Dr. Bonnie Robson's article, in this December issue of MPPA [MPPA 2004;19(4):160], about competition in the arts and sports and could
not help making associations between her article and the Olympics that I was watching on television.
Efeitos da natação no pico de fluxo em crianças asmáticas
Authors:   Universidad Miguel Hernández de Elche, Boechat De Oliveira Flávio , Soares Batista Suellen ,   Universidade Estácio de Sá, Dias De Oliveira Brum Rosana ,   Universidade Estácio de Sá, Soares Pernambuco Carlos ,   Universidade Estácio de Sá
Published: February 2021

Antecedentes: El asma és un problema crónico que provoca que las vías respiratórias se enfermas, probocando inflamación, broncoespasmos, afectando a los bronquios. Objetivos: Investigar si existe algún cambio en el pico de flujo en niños en clases de actividades acuáticas. Método: Estudio del tipo experimental con grupo control. Fuerón selecionados 7 niños que estában activos en un programa de natación, con una frecuencia de dos veces por semana con edades de 5 a 12 años. El instrumento de evaluación fue medir el pico de flujo respiratorio y una balanza de peso. Se llevaron a cabo estadísticos descritivos. Fue utilizado el test T del Student para la comparación interna y externa de los grupos. El nível sgnificativo p < .05. Resultados: Se encontraron diferencias significativas después de la intervención en los dos grupos con p < 0.04 en grupo control sadios y p < 0.003 en el grupo con asma. No hubo diferencias significativas entre los grupos observados. Conclusiones: El ejercicio de natación mejoró en el pico de flujo expiratório. La natación es un buen ejercicio para niños con deficiencias respiratorias
Efeitos de 12 meses de hidroginástica sobre o estado nutricional, pressão arterial de repouso e dosagem medicamentosa de idosas hipertensas
Authors: De Souza Sodré Ravini , Da Silva Soares Renata Pitilo , De Paula Silva Glória , Magalhaes Da Fonseca Tatiane , Braga De Mello Danielli , Rosa Ghilherme
Published: February 2021

Introdução: Os exercícios físicos em meio aquático, como a hidroginástica, vêm sendo sugeridos como forma de prevenção e tratamento não farmacológico para a hipertensão arterial sistêmica (HAS).
Objetivos: verificar o efeito de 12 meses de hidroginástica sobre o estado nutricional, a pressão arterial de repouso e a dosagem medicamentosa diária de idosas hipertensas.
Métodos: 17 mulheres hipertensas, praticantes de hidroginástica, foram divididas de acordo com o medicamento utilizado: G1 (Enalapril®, n=5, 67,0 ± 6,0 anos), G2 (Losartana®, n=7, 64,2 ± 4,3 anos), e G3 (Atenolol®, n=5, 73,8 ± 6,6 anos). Foram utilizadas as medidas de massa corporal, estatura e Índice de Massa Corporal (IMC). A pressão arterial (PA) foi avaliada com esfigmomanômetro digital (HEM-7200, OMRON®). As informações sobre os medicamentos foram obtidas através de entrevista. As voluntárias participaram de aulas de hidroginástica, durante 12 meses, 2x/semana.
Resultados: A única variável a apresentar diferença significativa nos grupos G2 e G3 foi a pressão arterial diastólica (PAD). Não foi observada diferença significativa ao comparar pré e pós intervenção para as outras variáveis investigadas. Não foram observadas diferenças significativas na dosagem de medicamentosa e na comparação intergrupos.
Conclusões: A prática de hidroginástica não apresentou alterações no estado nutricional e na pressão arterial de repouso de idosas hipertensas. A PAD apresentou um aumento significativa possivelmente pelo melhor retorno venoso e maior débito cardíaco ocasionado pela prática regular de exercício e pela pressão mecânica da musculatura contraída sobre os vasos sanguíneos dos membros inferiores.
Palavras-chave: Promoção da saúde; exercício físico; hipertensão; atividades aquáticas.
Una historia de la enseñanza de la natación en la Educación Física vista a través de los currículos reales de los profesores de campo en Francia
Authors: Auvray Emmanuel
Published: February 2021

Antecedentes: En educación fïsica, como en otras materias, son conocidos y aplicados los estudios de personas de relevancia nacional e internacional. Sin embargo, los docentes anónimos, que en definitiva son los que aplican el currículo y le dan un carácter real, tienen mucho que decir en este sentido. La inclusión de la natación dentro de la materia de educación física ha sufrido una gran evolución a lo largo de los años, y son los profesores de campo los que más tienen que aportar al respecto.
Objetivos: El propósito de este estudio fue dar cuenta de una investigación histórica sobre la evolución, según una población de profesores de educación física anónimos, de prácticas educativas escolares relacionadas con la natación en Educación Secundaria (Bachillerato, Educación Secundaria Obligatoria) durante la segunda mitad del siglo XX.
Método: Se ha llevado a cabo una encuesta por cuestionario semiestructurado, completado con los testimonios escritos, y los registrosimpresos privados y semi-oficiales, donde han participado un total de 158 profesores de diferentes niveles educativos pertenecientes a 25 academinas educativas.
Resultados: Se desprende de este estudio una periodización constituida en tres periodos: una natación utilitaria (1945-1959), una natación a la sombra de la natación deportiva federativa (1960-1986), y una natación que gira sobre ella misma (1987-2000). Además, a nivel local, existe una diversidad relativa de currículos reales, que sin embargo siguen estando basados en los currículos nacionales formales de educación física.
Conclusiones: Concretamente, la disparidad curricular (real-oficial) parece estar relacionada con un conjunto de variables que dependen a nivel macro de los diferentes recorridos biográficos personales y profesionales de los profesores de campo; a nivel meso a los contextos educativos locales; y a nivel micro a la evolución en la identidad de la educación física y discursos sobre la pedagogía y la didáctica de la natación. Esta disparidad real nos hace cuestionarnos la democratización efectiva de la educación física a nivel nacional frente al lema de la República francesa "libertad, igualdad y fraternidad”.
Palabras clave: Natación, historia, educación física y deportiva, curriculum y prácticas pedagógicas.
Código de buenas prácticas en las instalaciones acuáticas
Authors: Albarracín Pérez Apolonia , Moreno Murcia Juan Antonio
Published: February 2021

Antecedentes: Son pocas la evidencias y propuestas que se pueden encontrar acerca de reflexiones sobre cómo se puede llevar a cabo la práctica de las actividades acuáticas, y que sirvan de ayuda de forma transversal a usuarios, formadores y gestores de instalaciones. El poder unificar criterios y clarificar estos procesos acuáticos, pueden ayudar a mejorar la eficiencia de todas aquellas acciones que se puedan llevar a cabo alrededor del ejercicio acuático.
Objetivos: Realizar una propuesta de buena praxis en las actividades acuáticas, siendo la base para proponer una guía que sirva de base para la organización y puesta en práctica de todos los programas realizados en las instalaciones acuáticas.
Método: Se analizaron todos los estudios que relacionan el ejercicio acuático con las instalaciones, metodología y normativa. Se llevó a cabo el análisis de los mismos para realizar dicha propuesta, a través de las bases de datos Medline, Scielo, ScienceDirect, Scopus, Google Scolar, Web of Science.
Resultados: Se han realizado propuestas en tres líneas, siendo por un lado las personas implicadas en todos los procesos acuáticos (ususarios, formadores y familias), el método utilizado en cada uno de ellos y la necesidad de que la instalación sea adecuada para cada caso.
Conclusiones: Se presenta un documento inicial como paso previo para elaborar una guía práctica de buenas prácticas que ayude a usuarios, gestores y profesionales a ubicar de forma más adecuada las necesidades de cada una de las iniciativas de ejercicio acuático que se están llevando a la práctica en las instalaciones.
Palabras clave: Programas acuático, piscinas, usuarios, formadores, método.
Protocolos de intervención en piscinas cubiertas de la Región de Murcia
Authors: Cano Noguera Francisco , Hernández Luján Irene
Published: February 2021

Antecedentes: Las muertes por ahogamiento son el peor resultado que puede tener la interacción del ser humano con el medio acuático.
Objetivo: El objetivo del presente estudio  fue estudiar la seguridad de las piscinas cubiertas de la Región de Murcia, desde el punto de vista de la posesión de un protocolo de actuación en caso de accidente.
Método: Para ello se contó con la participación de 26 piscinas. Tras la revisión de la legislación se elaboró una entrevista con el fin de recabar información sobre los recursos humanos y materiales de los que disponía la instalación en caso de incidente.
Resultados: Se obtiene la obligatoriedad por parte de las piscinas de poseer un protocolo de autocontrol de la instalación en el que recoger las medidas de las que se disponen para la seguridad de esta. El 19,23% de las piscinas encuestadas no contaba con un procedimiento de actuación en caso de accidente.
Conclusiones: La conclusión principal es que no existe la obligación de disponer de un protocolo de actuación en caso de accidente, y se requiere la creación de un protocolo que cubra el mayor número de situaciones y que establezca entre otras cosas la coordinación entre el personal y las acciones de salvamento a llevar a cabo.
Palabras clave: Seguridad, Prevención, Piscina, Ahogamiento, Coordinación de socorristas.
Efectos de un programa de entrenamiento compensatorio en seco sobre la postura del hombro y la posición escapular de nadadoras de competición
Authors: Sousa João Paulo , Malta João , Carrageta Ana , Batalha Nuno
Published: February 2021

Antecedentes: Los nadadores de competición exigen mucho a los aductores del hombro y a los músculos rotadores internos debido a la naturaleza repetitiva de los movimientos de natación.
Objetivos: Evaluar el efecto de un programa de entrenamiento compensatorio en seco sobre la postura del hombro y la posición escapular de las nadadoras de competición.
Método: 25 nadadoras de competición de nivel nacional recibieron un programa de intervención de 8 semanas centrado en el fortalecimiento de los músculos posteriores de la cintura escapular y el estiramiento de los músculos anteriores del hombro. La muestra del estudio estuvo expuesta a un periodo de control de 2 semanas y a un periodo de intervención de 8 semanas.
Resultados: Se encontraron diferencias significativas tras el periodo de intervención, tanto en el lado dominante como en el no dominante, con respecto a la protracción del hombro (distancia entre la cara anterior del acromion a la pared - p < 0,05) y la abducción escapular (distancia entre una línea medial marcada sobre la apófisis espinal torácica y el borde medial de la espina escapular - p < 0,05; y distancia entre una línea medial marcada sobre la apófisis espinal torácica y el borde medial de la espina escapular - p < 0,05).
Conclusiones: Los resultados revelaron que la incorporación de un programa de entrenamiento compensatorio en seco junto a un entrenamiento normal en el agua redujo significativamente la distancia de la postura del hombro en protracción y la posición escapular en abducción.
Palabras clave: protracción del hombro, abducción escapular, entrenamiento en seco, natación, mujer.
Efectos de la intervención con el método watsu en jóvenes nadadores de competición brasileños: asistencia, necesidades y efectos experimentados
Authors: Lima Costa Ana Carolina , Sanz-Arribas Ismael , Hernández-Álvarez Juan Luís
Published: February 2021

Objetivos: El objetivo de este estudio es conocer los efectos generados por una intervención del método Watsu en un grupo de 11 nadadores de competición (6 hombres y 5 mujeres), con edades comprendidas entre los 13 y los 21 años.Método: Para la consecución de este objetivo, todos los participantes de este estudio recibieron 20 sesiones de método Watsu, durante 20 semanas. Las sesiones del método Watsu, fueron añadidas a la rutina de entrenamiento de los nadadores, sin que ello supusiera una alteración del trabajo inicialmente diseñado para los deportistas que participaron en la investigación. Para el análisis de los datos, se utilizaron instrumentos y procedimientos de carácter cuantitativo (ej. cuestionarios) y cualitativo (ej. diarios) durante todo el proceso de intervención.Resultados: Los resultados demostraron que los participantes de esta investigación interpretaron que el método Watsu es una herramienta válida y necesaria para mejorar los aspectos físicos y psicológicos dentro y fuera del ambiente deportivo.Conclusiones: En definitiva, se concluye que el método Watsu puede ayudar a mejorar el nivel de relajación, descanso y consciencia corporal de aquellos deportistas que se ven expuestos a un alto nivel de exigencia deportiva y/o de competición.Palabras clave: Natación; Rendimiento deportivo; Técnicas de relajación; bienestar.
A New Way of Compositional Simulation without Phase Labeling
Authors: Khorsandi Saeid , Li Liwei , Johns Russell T.
Published: February 2021

Current relative permeability models rely on labeling a phase as “oil” and “gas” and cannot therefore capture accurately the effect of compositional variations on relative permeabilities and capillary pressures in enhanced oil recovery processes. Discontinuities in flux calculations caused by phase labeling problems not only cause serious convergence and stability problems but also affect the estimated recovery factor owing to incorrect phase mobilities.

We developed a fully compositional simulation model using an equation of state (EoS) for relative permeabilities (kr) to eliminate the unphysical discontinuities in flux functions caused by phase labeling issues. The model can capture complex compositional and hysteresis effects for three-phase relative permeability. Each phase is modeled separately based on physical inputs that, in part, are proxies to composition. Phase flux calculations from one gridblock to another are also updated without phase labels. The tuned kr-EoS model and updated compositional simulator are demonstrated for simple ternary cases, multicycle three-phase water-alternating-gas (WAG) injection, and three-hydrocarbon-phase displacement with complex heterogeneity. The approach improves the initial estimates and convergence of flash calculations and stability analyses, as well as the convergence in the pressure solvers. The new compositional simulator allows for high-resolution simulation that gives improved accuracy in recovery estimates at significantly reduced computational time.
HSF1 promotes endometriosis development and glycolysis by up-regulating PFKFB3 expression
Authors: Wang Yixin , Xiu Jing , Yang Tingting , Ren Chune , Yu Zhenhai
Published: February 2021

Background Endometriosis is a chronic hormonal inflammatory disease characterized by the presence of endometrial tissue outside the uterus. Endometriosis often causes infertility, which affects the body and mind of patients and their families.Methods We examined the functions of heat shock factor 1 (HSF1) in endometriosis development through cell count, scratch and clone formation experiments. We used quantitative real-time PCR (qRT-PCR) and Western blot (WB) to detect the functions of HSF1 in endometriosis cells. Glucose and lactate levels were determined using a glucose (GO) assay kit and a lactate assay kit. Furthermore, we established a mouse model of endometriosis by using a HSF1 inhibitor-KRIBB11.Results Our study demonstrated that HSF1 was highly expressed in endometriosis, and promoted endometriosis development. Interestingly, we found that HSF1 promoted glycolysis in endometriosis cells. Further, HSF1 enhanced glycolysis by up-regulating PFKFB3 in endometriosis cells, which was a key enzyme in glucose metabolism. Moreover, the HSF1 inhibitor KRIBB11 could abrogate endometriosis progression in vivo and in vitro.Conclusions Findings indicate that HSF1 plays an important role in the development of endometriosis, which might become a new target for the treatment of endometriosis and provide a new idea for the clinical treatment of endometriosis.Electronic supplementary material Supplementary data are available.
Ratio of T790M to EGFR-activating mutation predicts response of osimertinib in 1st or 2nd - generation EGFR-TKI-refractory NSCLC
Authors: Tamiya Motohiro , Tamiya Akihiro , Okamoto Norio , Taniguchi Yoshihiko , Nishino Kazumi , Atagi Shinji , Hirashima Tomonori , Imamura Fumio , Kumagai Toru , Suzuki Hidekazu
Published: February 2021

Background: Afatinib followed by osimertinib (Afa group) may reportedly provide better outcomes for T790M-positive non-small cell lung cancer (NSCLC) than 1st-generation (G) epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) (1st-G group). Methods: We studied 111 consecutive patients with T790M mutation-positive NSCLC who were treated with osimertinib after progression following 1st- or 2nd-G EGFR-TKI between March 28, 2016 and March 31, 2018. We analyzed T790M ratio with the re-biopsy tissue, obtained after EGFR-TKI resistance using droplet digital polymerase chain reaction, and investigate whether afatinib prifies the T790M mutation more than 1st-G EGFR-TKI.Results: Among the 60 patients with preserved re-biopsy tissues, we analyzed 38 patients whose re-biopsy tissue had adequate DNA content. Eleven patients in the Afa group had 81.8% of response rate, and 27 patients in the 1st-G group had 85.2% with RR. The mean T790M ratio was 0.3643. The T790M ratio in those with response of the osimertinib group was significantly higher than in those with non-response group (p=0.0272) and was similar in the Afa and 1st-G group (p=0.9693).Conclusion: T790M ratio significantly correlated with osimertinib response and T790M ratio was similar between the 1st and 2nd -G EGFR-TKIs in 1st or 2nd -G EGFR-TKI-refractory tumors.
Identification of Potential Gene Expression in Hepatitis B Virus-induced Liver Cancer Using the Simulated Annealing Algorithm
Authors: Muflikhah Lailil , Widodo  , Mahmudy Wayan Firdaus , Solimun
Published: February 2021

BackgroundLiver cancer is often associated with hepatitis B infection, and there is a progression from chronic hepatitis to hepatocellular carcinoma. The replication of the virus affects the cell cycle of the host. Many oncogenes that express themselves in the formation of proteins can be highly expressed. A microarray technique can be used as a high throughput measure to determine gene expression in the mechanism of hepatoma progression. However, it has lacks important information on the potential genes to trigger the disease. The information is about the produced mRNA and has a difference to the normal cell line as control. ResultsThis study aimed to identify the potential genes that could be used as predictors to detect liver cancer using a heuristic algorithm, simulated annealing optimization. The basic idea of this algorithm was to overcome the combinatorial problem using probability values to select the significant features as a predictor for the classifier model in the representative machine learning algorithms, such as SVM, KNN, Naïve Bayes. C5.0 Decision Tree, and Random Forest. The experimental results showed quite high performance, more than 90% on average. However, using the simulated annealing algorithm requires substantial computation time to identify genes that could be used for detecting liver cancer.Conclusion A large amount of gene expression data can be reduced by identifying the potential gene as a predictor in the liver cancer mechanism. Using simulated annealing optimization, the experiment result obtained almost all the selected gene belongs to the type of protein-coding in liver tumor progression. Using cross-validation, the result achieved high performance even though the required time for selection is higher than classification using the machine learning method.
Fault Diagnosis of Rolling Bearing based on an Improved Denoising Technique using Complete Ensemble Empirical Mode Decomposition and Adaptive Thresholding Method
Authors: Sahu Prashant Kumar , Rai Rajiv Nandan
Published: February 2021

The vibration signals for rotating machines are generally polluted by excessive noise and can lose the fault information at the early development phase. In this paper, an improved denoising technique is proposed for early faults diagnosis of rolling bearing based on the complete ensemble empirical mode decomposition (CEEMD) and adaptive thresholding (ATD) method. Firstly, the bearing vibration signals are decomposed into a set of various intrinsic mode functions (IMFs) using CEEMD algorithm. The IMFs grouping and selection are formed based upon the correlation coefficient value. The noise-predominant IMFs are subjected to adaptive thresholding for denoising and then added to the low-frequency IMFs for signal reconstruction. The effectiveness of the proposed method denoised signals are measured based on kurtosis value and the envelope spectrum analysis. The presented method results on experimental datasets illustrate that the proposed approach is an effective denoising technique for early fault detection in the rolling bearing.
Plant Biomass and Soil Nutrients Mainly Explain the Variation of Soil Microbial Communities during Secondary Succession on the Loess Plateau
Authors: Xu Miao-Ping , Wang Jia-Yi , Han Xin-Hui , Ren Cheng-Jie , Yang Gai-He
Published: February 2021

Soil microorganisms play an important role in the circulation of materials and nutrients between plants and soil ecosystems, but the drivers of microbial community composition and diversity remain uncertain in different vegetation restoration patterns. We studied soil physicochemical properties (i.e., soil moisture, bulk density, pH, soil nutrients, available nutrients), plant characteristics (i.e., Shannon index [HPlant] and Richness index [SPlant], litter biomass [LB], and fine root biomass [FRB]), and microbial variables (biomass, enzyme activity, diversity and composition of bacterial and fungal communities) in different plant succession patterns (Robinia pseudoacacia [MF], Caragana korshinskii [SF] and grassland [GL]) on the Loess Plateau. The herb communities, soil microbial biomass and enzyme activities were strongly affected by vegetation restoration. And soil bacterial and fungal communities were significantly different from each other at the sites. Furthermore, LB and FRB were significantly positively correlated with SBacteria, soil microbial biomass, enzyme activities, Proteobacteria, Zygomycota and Cercozoa, while negatively correlated with Actinobacteria and Basidiomycota. In addition, soil water content (SW), pH and nutrients have important effects on the bacterial and fungal diversities, Acidobacteria, Proteobacteria, Nitrospirae, Zygomycota and microbial biomass. Furthermore, plant characteristics and soil properties modulated the composition and diversity of soil microorganisms, respectively. Overall, the relative contribution of vegetation and soil to the diversity and composition of soil bacterial and fungal communities illustrated that plant characteristics and soil properties may synergistically modulate soil microbial communities. And soil bacterial and fungal communities mainly depend on plant biomass and soil nutrients.
Effectiveness of Naloxegol in Patients With Cancer Pain Suffering From Opioid-Induced Constipation
Authors: Lemaire Antoine , Pointreau Yoann , Narciso Bérengère , Piloquet François-Xavier , Braniste Viorica , Sabaté Jean-Marc
Published: February 2021

Purpose

Naloxegol, an oral once-daily peripherally acting mu-opioid receptor antagonist, is indicated for the treatment of opioid-induced constipation (OIC) with inadequate response to laxative(s), in cancer and non-cancer patients. This study mainly aimed to assess in real-life conditions the efficacy and safety of naloxegol in cancer pain patients, and the evolution of their quality of life.
Methods

A non-interventional, 4-week follow-up study was conducted in 24 French oncology and pain centers between 2018 and 2019. Eligible patients were aged ≥ 18 years, treated with opioids for cancer-pain, and started naloxegol for OIC with inadequate response to laxatives. The rate of the response to naloxegol (primary criterion) was assessed at W4. The evolution of quality of life was measured using the Patient Assessment of Constipation Quality of Life (PAC-QOL).
Results

A total of 124 patients were included (mean age: 62 ± 12 years; ECOG ≤ 2: 79%; primary cancer: lung 18%, breast 16%, prostate 11%, head and neck 9%, digestive 9%...; metastatic stage: 80%). At inclusion, the median opioid dosage was 60 mg of oral-morphine or equivalent. At W4, the response rate was 73.4% (95% CI [63.7%-83.2%]) and 62.9% (95% CI [51.5%-74.2%]) of patients had a clinically relevant change in quality of life (decrease in PAC-QOL score ≥ 0.5 point). Adverse events related to naloxegol were reported in 8% of patients (7% with gastrointestinal events; one serious diarrhea).
Conclusion

This real-world study shows that naloxegol is effective and well tolerated in cancer pain patients with OIC and that their quality of life improves under treatment.
Multifunctional Molecule, JM-20, Reverses Aluminum Chloride-Induced Memory Impairment and Neuronal Damage in Rats
Authors: Wong-Guerra Maylin , Montano-Peguero Yanay , Ramírez-Sánchez Jeney , Jiménez-Martin Javier , Fonseca-Fonseca Luis Arturo , Hernández-Enseñat Daniela , Nonose Yasmine , Valdés Odalys , Mondelo-Rodriguez Abel , Ortiz-Miranda Yaquelin , Bergado Gretchen , Carmenate Tania , Valle Roberto Menéndez Soto del , Pardo-Andreu Gilberto , Outeiro Tiago Fleming , Padrón-Yaquis Alejandro Saúl , Assis Adriano Martimbianco de , Souza Diogo O , Nunez-Figueredo Yanier
Published: February 2021

Alzheimer's disease (AD) is a neurodegenerative disease that worsens with aging. Today, there is a worldwide effort to find new drugs that could delay the onset, slow the progression, or improve symptoms of AD. Oral administration of aluminum to rodents recapitulates some pathological alterations observed in AD, being considered a convenient tool for modeling and testing the efficacy of new therapeutics. Our previous studies have shown that JM-20, a dihydropyridine and benzodiazepine hybrid molecule protected memory in an environment with cholinergic dysfunction, high oxidative stress, hyperactivation of acetylcholinesterase (AChE) enzyme, and mitochondrial damage produced by scopolamine. In order to gain further insight into the effects on JM-20 on AD pathology, we evaluated the protective effects of JM-20 after chronic AlCl3 administration to rats, and assessed several types of episodic memory alterations and associated-pathological mechanisms, including mitochondrial dysfunction, AChE hyperactivity, inflammation, and apoptosis-related proteins. We used behavioral tasks to test spatial, working an emotional- associative memory, as well as molecular, enzymatic and histological assays to evaluate selected biochemical parameters. Our study showed that JM-20 prevented memory decline alongside with the inhibition of aluminum-induced alterations of oxidative parameters, and increase of AChE activity and of tumor necrosis factor alpha (TNF-α) levels. JM-20 also preserved anti-apoptotic proteins and protected against axonal and neuronal damaged in the hippocampus and prefrontal cortex. Altogether, our findings expanded our understanding of the ability of JM-20 to preserve essential types of memory in rats under neurotoxic conditions, and suggest its potential capacity to counteract etiological factors of AD by breaking the progression of key neurodegeneration-associated steps in a rat model of the disease.
Impact of Green Entrepreneurship Orientation on Environmental Performance: The Natural Resource-Based View Perspective
Authors: Makhloufi Lahcene , Meirun Tang , Belaid Fateh , Yaacob Noorulsadiqin Azbiya
Published: February 2021

Environmental sustainability is the primary task of environmental entrepreneurship by critically handling increased institutional, customer, and environmental pressures. Green entrepreneurship orientation (GEO) seeks to harmonize their relationships with the external environment to foster the impact of green innovation performance (GIP) on environmental performance (EP). Drawing upon the natural resource-based view, the study examines the effect of green entrepreneurship orientation on GIP and EP. Additionally, the moderating effect of managerial environmental concerns (MEC) on this relationship is also inspected. The results revealed that green absorptive capacity (GAC), environmental cooperation (EC), and MEC significantly affect GEO. Furthermore, GEO positively influenced GIP and EP. Indeed, GEO partially mediates GAC, EC, and managerial concern’s relationship on green innovation and EP. Additionally, MEC significantly moderates the relationship between GEO and EP. Firms GEO should adequately enhance green practices performance and environmental performance to accommodate their external environment relationships. Theoretical and practical implications were also presented.
Preparation and Dielectric Properties of the Amorphous Basaltic Glass
Authors: Liu Changjiang , Tong Xiaocong , Yang Chuncheng , Jiang Letao , Li Yan , Zhang Lei , Ding Baoming , Liu Zhong , Huang Heyu , Li Hongchao
Published: February 2021

Due to the continuous basalt fiber is a kind of amorphous material, only the basaltic glass without crystallization can represent its dielectric properties. To explore the dielectric properties of the continuous basalt fiber, amorphous basaltic glass must be prepared. The present research focuses on the influence of chemical component on the preparation process of the amorphous basaltic glass and its dielectric properties. The basaltic rocks from different places of China were melted at 1500℃, then the melt was poured into the mould, at last glass sample was annealed at 650℃ for 2h. Ten groups of basaltic rocks were studied, and the results showed that the melt viscosity of basaltic rocks with 55-58% SiO2 was poor at 1500℃. The high-content of Fe2O3 and TiO2 in basaltic rocks was found to enhance the formation of magnetite (Fe3O4) crystal during the annealing process. The other five groups of basaltic rocks were suit to the amorphous basaltic glass. At 1MHz, the best dielectric constant of amorphous basaltic glass is 6.55, the dielectric loss is 4.034×10-3.
Adipose-Derived Stromal Vascular Fraction and Fat Grafts Versus Medical Treatment for Treating the Hands of Patients With Systemic Sclerosis. A Randomized Crontolled Trial
Authors: Iglesias Martin , Torre-Villalvazo Ivan , Butrón-Gandarillas Patricia , Rodríguez-Reyna Tatiana S , Torre-Anaya Erik A , Tovar-Palacio Armando R , Zentella-Dehesa Alejandro , Guevara-Cruz Martha , Hernandez-Campos Alan M
Published: February 2021

Background. In the hand, the Systemic Sclerosis (SS) is characteristically evidenced by Raynaud's phenomenon (RP) and fibrosis of the skin, tendons, ligaments, and joints as well as digital ulcers with prolonged healing. Current medical treatment not always cure these complications. Local adipose-derived stromal vascular fraction (ADSVF) administration into the hands has been proposed as an emerging treatment for these complications, due to its proangiogenic, antifibrotic, and immunoregulatory activities. The objective of this controlled trial was to evaluate the safety and clinical effects of fat micrografts plus ADSVF administration into the hands of patients with SS.Methods. This was an open-label, monocentric, randomized controlled study. Twenty patients diagnosed with SS were enrolled and assigned to the experimental or control group. Fat micrografts plus the ADSVF were injected into the right hand of experimental group patients. The control group continued to receive only medical treatment. Demographic, serologic data and disease severity were recorded. Digital oximetry, pain, Raynaud phenomenon (RP), digital ulcer healing (DUH), mobility, thumb opposition, vascular density of the nail bed, skin affection of the hand, Serologic antibodies, hand function, and quality of life scores were evaluated in both groups. The mean follow-up period was 168 days. The differences between before and after the intervention were analyzed with the Wilcoxon range test, and the differences between the control and experimental groups at 0 days and 168 days were analyzed with the Mann–Whitney U test.Results. Adverse events were not observed in both groups. There were no changes in disease severity, serologic antibodies, nailfold capillaroscopy patterns, mobility, and hand function in both groups. There were significant improvements in pain, DUH and quality of life scores in the experimental group. RP improved significantly in both groups. However, on statistically comparing the results at 168 days between the groups, significant improvements were only observed in pain levels (p = 0.02) and DUH (p=0.003).Conclusions. The injection of ADSVF plus fat micrografts is a reproducible, and safe technique. Pain and digital ulcers in the hands of patients with SS can be treated with this treatment. Trial Registration: Retrospectively registered in ClinicalTrials.gov with identifier NCT04387825
Sustainable Approaches Towards Aquaculture: Microalgal Circular Economy Perspectives
Authors: Mishra Bharti , Tiwari Archana , Mahmoud Alaa El Din
Published: February 2021

Microalgae have higher nutritional value as they are abundant in protein, carbohydrates, lipids, and vitamins. Hence, they play several important roles in aquaculture and are known as a major source of the food chain for aquaculture organisms. Furthermore, they are also used indirectly or directly by humans as food supplements and medicines to improve health by strengthening the immune system. Microalgae are used as biocontrol agents because they have biocidal properties, produce biomolecules (beta carotene, PUFA, and astaxanthin), wastewater, are a renewable resource of biofuel, and are used in wastewater treatment. Due to the overexploitation of wild fish and pollution, aquaculture faces serious issues. Eco- friendly methods are required to overcome this problem, so, microalgae are in practicing, that control the water pollution. Fishmeal is a rich source of protein in aquaculture but it is decreasing over time and has become cost-effective, so, to solve the problem, microalgae are used to replace the fishmeal which (microalgae as aquafeed) is cheap and not required large area to grow. Microalgae are seemed to be very useful in the growth enhancement of aquatic organisms.