bluuebunny/crossref_metadata_2025 huggingface dataset:
New onset autoimmune diabetes mellitus and hypothyroidism secondary to pembrolizumab in a patient with metastatic lung cancer
Authors: Cunha Clara , Silva Eugénia , Vieira Ana Cláudia , Saraiva Catarina , Duarte Sequeira
Published: February 2022

Immunotherapy has become an important pillar for the management of advanced cancer. Immune-related adverse events including endocrinopathies have been well described with programmed cell death 1 inhibitors such as pembrolizumab. While thyroid dysfunction is the most common endocrinopathy associated with pembrolizumab, new-onset autoimmune diabetes mellitus (DM) is extremely rare. The authors report a case of pembrolizumab-induced primary hypothyroidism and type 1 diabetes mellitus presenting with diabetic ketoacidosis (DKA). A 59-year-old female patient was treated with pembrolizumab for a stage 4 lung adenocarcinoma. She presented to the emergency department with hyperglycaemia-related signs and symptoms, such as polyuria, polydipsia, weight loss, vomiting, asthenia and dehydration, 3 weeks after her first dose of pembrolizumab. Laboratory evaluation revealed hyperglycaemia, hyperketonaemia and high anion gap metabolic acidaemia consistent with DKA. After prompt and adequate treatment of DKA, she transitioned to s.c. basal-bolus insulin. The diagnose of autoimmune DM was established based on the undetectable C-peptide levels and seropositivity for antiglutamic acid decarboxylase antibodies. Additional hormonal parameters revealed overt hypothyroidism and levothyroxine therapy was initiated. This case highlights the importance of blood glucose and thyroid function monitoring as an integral part of cancer treatment protocols for pembrolizumab and other immune checkpoint inhibitors.

Learning points

Programmed cell death 1 (PD1) inhibitors such as pembrolizumab can cause endocrine immune-related adverse events (irAE), including thyroid dysfunction and type 1 diabetes mellitus (T1DM).

Thyroid dysfunction is the most frequent endocrine irAE secondary to PD1 inhibitors.

Autoimmune diabetes and possible resultant diabetic ketoacidosis are rare, but life-threatening adverse events associated with pembrolizumab.

Pembrolizumab-induced T1DM often present with relatively low HbAlc levels, reflecting the fulminant onset of β-cell destruction.

Patients treated with pembrolizumab and other immune checkpoints inhibitors should be monitored regularly for hyperglycaemia and thyroid dysfunction.
Thyrotoxic periodic paralysis associated with Graves’ disease: a case series
Authors: Ludgate S , Lin M , Mayadunne M , Steen J , Ho K W
Published: February 2022

Thyrotoxic periodic paralysis (TPP) is a rare condition characterised by acute onset hypokalaemia and paralysis which most commonly affects men of Asian descent between the ages of 20 and 40 years (1, 2). It has been reported in approximately 2% of patients with thyrotoxicosis in China and Japan (1, 2, 3). Hypokalaemia in TPP results from a massive intracellular shift of potassium induced by the thyroid hormone sensitisation of Na+/K+-ATPase (4). Treatment of TPP includes prevention of this shift by using beta-blockade, rapid potassium replacement and treatment of the underlying hyperthyroidism. We present two cases of TPP with differing outcomes. In the first case, a 33-year-old Filipino gentleman presented to our emergency department (ED) with a 3-month history of recurrent proximal lower limb weakness. Serum potassium was 2.2 mmol/L (3.3–5.1) and he was given i.v. potassium replacement. Thyroid function tests (TFTs) and thyroid antibodies were consistent with Graves thyrotoxicosis. He was discharged home on carbimazole and remains well controlled on long-term medical therapy. In the second case, a 22-year-old Malaysian gentleman presented to our ED with new-onset bilateral lower limb painless paralysis. Serum potassium was 1.9 mmol/L with TFTs demonstrating Graves thyrotoxicosis. He was treated with i.v. potassium replacement and discharged home on carbimazole and propranolol. He represented to the hospital on two further occasions with TPP and was advised to consider total thyroidectomy given his refractory Graves’ disease. These cases highlight the importance of prompt recognition of this rare life-threatening complication of Graves’ disease, especially in patients of Asian descent.

Learning points

Thyrotoxic periodic paralysis is a rare condition characterised by hypokalaemia and acute painless muscle weakness in the presence of thyrotoxicosis.

The signs and symptoms of thyrotoxicosis can be subtle in these patients.

It is most commonly seen in Asian males between the ages of 20 and 40 and is most frequently caused by Graves’ disease.

Prompt recognition is essential as it is a life-threatening condition.

Urgent i.v. potassium replacement and beta-blockade with a non-selective beta-blocker are the mainstays of treatment.

i.v. potassium replacement should not be given in dextrose as this can potentiate hypokalaemia.
Ocena wartości MIC na wybrane leki przeciwbakteryjne u Streptococcus agalactiae izolowanych od kobiet ciężarnych – badania wstępne
Authors: Sikora Agnieszka , Majszczyk Klaudia , Sikora-Futyma Anna
Published: February 2022

Wstęp Paciorkowce z grupy B stanowią główny czynnik etiologiczny zakażeń okołoporodowych oraz wczesnych i późnych zakażeń noworodków. Wdrożenie odpowiednej okołoporodowej profilaktyki antybiotykowej u kobiet ciężarnych, będących nosicielkami GBS, zmniejsza ryzyko zakażeń inwazyjnych u noworodków, a tym samym przyczynia się do zmniejszenia zachorowalności i śmiertelności. Cel Celem pracy była ocena wartości minimalnego stężenia hamującego na penicylinę, ampicylinę, cefazolinę, klindamycynę oraz wankomycynę. Materiał i metody Materiał stanowiło 20 szczepów GBS izolowanych od kobiet ciężarnych pomiędzy 35. a 37. tygodniem ciąży z pochwy i/lub odbytnicy. Profil lekowrażliwości analizowanych szczepów zbadano przy użyciu E-testów®. Wyniki Wszystkie szczepy wykazały wrażliwość na antybiotyki β-laktamowe, tj. penicylinę, ampicylinę, cefazolinę, oraz na antybiotyk glikopeptydowy – wankomycynę. Stwierdzono oporność na erytromycynę u 9 przebadanych szczepów, a na klindamycynę u 7. Wnioski Paciorkowce grupy B pozostają wrażliwe na antybiotyki β-laktamowe. Penicylina, która wykazała największą skuteczność, powinna pozostać lekiem pierwszego wyboru w okołoporodowej profilaktyce antybiotykowej. Odnotowano oporność GBS na erytromycynę i klindamycynę, co zwraca uwagę na konieczność oceny lekowrażliwości szczepów przed ich zastosowaniem. Pomimo wykazanej skuteczności wankomycyny u wszystkich przebadanych szczepów, należy zachować ostrożność przy stosowaniu tego leku, jako leku ostatniej szansy.
Gestión educativa y desempeño. Estudio correlacional en la provincia de Recuay, Perú
Authors: Yépez Huamán René Gabriel
Published: February 2022

El presente estudio tiene como propósito identificar las características de la gestión educativa y el desempeño docente, mediante la cual el personal directivo realiza diferentes acciones destinadas para que el profesor realice sesiones de aprendizaje de calidad para lograr aprendizajes significativos en los estudiantes. En dicho contexto, surge la siguiente pregunta ¿hasta qué punto la gestión educativa se relaciona con la mejora del desempeño docente? Metodológicamente, el estudio posee alcance correlacional. Se llegó a concluir que las actividades pedagógicas de la plana directiva ejercen una influencia positiva para la mejora del desempeño docente.
Ефективна трифотонна вершина у густому ферміонному середовищі
Authors: Резніков Є.В. , Скалозуб В.В.
Published: February 2022

Обчислено тензор ефективної трифотонної вершини для випадку середовища з ненульовим хімічним потенціалом μ в однопетльовому наближенні. Проаналізовано властивості тензора залежно від довжини хвилі та частоти зовнішніх фотонів. Проведено детальне дослідження окремого випадку розсіяння вільних фотонів на магнітному полі. Обговорено можливі застосування отриманих результатів.
Induced Vacuum Current and Magnetic Flux in Quantum Scalar Matter in the Background of a Vortex Defect with the Neumann Boundary Condition
Authors: Gorkavenko V.M. , Gorkavenko T.V. , Sitenko Yu.A. , Tsarenkova M.S.
Published: February 2022

A topological defect in the form of the Abrikosov–Nielsen–Olesen vortex in the space of an arbitrary dimension is considered as a gauge-flux-carrying tube that is impenetrable for quantum matter. The charged scalar matter field is quantized in the vortex background with the perfectly rigid (Neumann) boundary condition imposed at the side surface of the vortex. We show that a current circulating around the vortex is induced in the vacuum, if the Compton wavelength of the matter field exceeds the transverse size of the vortex considerably. The vacuum current is periodic in the value of the gauge flux of the vortex, providing a quantum-field-theoretical manifestation of the Aharonov–Bohm effect. The vacuum current leads to the appearance of an induced vacuum magnetic flux that, for some values of the tube thickness, exceeds the vacuum magnetic flux induced by a singular vortex filament. The results are compared to those obtained earlier in the case of the perfectly reflecting (Dirichlet) boundary condition imposed at the side surface of the vortex. It is shown that the absolute value of the induced vacuum current and the induced vacuum magnetic flux in the case of the Neumann boundary condition is greater than in the case of the Dirichlet boundary condition.
Forming Clinician-Parent Therapeutic Alliance for Children With Severe Neurologic Impairment
Authors: Bogetz Jori F. , Trowbridge Amy , Lewis Hannah , Jonas Danielle , Hauer Julie , Rosenberg Abby R.
Published: February 2022

OBJECTIVES

Care for children with severe neurologic impairment (SNI) often involves complex medical decision-making where therapeutic alliance between clinicians and families is essential. Yet, existing data suggest that communication and alliance are often lacking. This study aimed to examine aspects important to developing therapeutic alliance between clinicians and parents of children with SNI.

METHODS

A purposive sample of expert clinicians and parents of children with SNI completed brief demographic surveys and 1:1 semistructured interviews between July 2019 and August 2020 at a single tertiary pediatric academic center. Interviews focused on the inpatient experience and transcriptions underwent thematic analysis by a study team of qualitative researchers with expertise in palliative care and communication science.

RESULTS

Twenty-five parents and 25 clinicians participated (total n = 50). Many parents were mothers (n = 17, 68%) of school-aged children with congenital/chromosomal conditions (n = 15, 65%). Clinicians represented 8 professions and 15 specialties. Responses from participants suggested 3 major themes that build and sustain therapeutic alliance including: (1) foundational factors that must exist to establish rapport; (2) structural factors that provide awareness of the parent/child experience; and (3) weathering factors that comprise the protection, security, and additional support during hard or uncertain times. Participants also shared concrete actions that promote these factors in clinical practice.

CONCLUSION

Therapeutic alliance between clinicians and parents of children with SNI consists of at least 3 factors that support communication and medical decision-making. These factors are facilitated by concrete actions and practices, which enhance communication about the care for children with SNI.
Assessment of Students’ Oral Communicative Competence in English Through a Web Conferencing Platform
Authors: Cruz-Ramos María de los Milagros , Herrera-Diaz Luz Edith
Published: February 2022

This manuscript reports on a study carried out at a public university in southeast Mexico aimed to determine whether changes in the instructional design of an online English course benefit students’ oral communicative competence. The research followed a quantitative quasi-experimental design that involved two groups of students. One of them took a modified version of an online English II course that provided contextualized instruction of the syllabus language topics. This group’s communicative competence was assessed online, which represented a major shift from the face-to-face assessments typically delivered to online groups. The results showed that online assessment is possible, and also that students’ communicative competence improved and was directly related to the intervention.
Framing English as a Medium of Instruction Within the Iberian-American Spanish-Speaking Education Contexts
Authors: Escobar-Alméciga Wilder Yesid
Published: February 2022

Education in Spain and Latin America has been experiencing an ever-increasing use of English as a medium of instruction at all levels and across curricula. Bringing the vast research-literature into a reflective dialogue is paramount to advancing the discipline and to refining English teaching practices. As such, this literature review systematically situates English-as-a-medium-of-instruction literature related to higher education within the Iberian-American school contexts where Spanish was the students’ first language. Thus, the paper asserts that while research that addresses methodological approaches, processes, procedures, and their effects in instruction is significant, there is still a pressing need for framing English-as-a-medium-of-instruction research within the reciprocal relationship existing among communication, classroom culture, social values, the classroom climate for learning, and ultimately, the students’ learning.
In-Service University-Level EFL Instructors’ Language Assessment Literacy and Training Needs
Authors: Sayyadi Ali
Published: February 2022

The study examined university-level English instructors’ assessment training experiences, classroom-based assessment practices, and assessment training needs in Iran. Sixty-eight instructors who were randomly selected through academic social networks filled out a questionnaire. Eight instructors were also interviewed. The results indicated that the instructors had received insufficient training, especially in practical aspects, because they had solely been exposed to assessment concepts and theories in the limited and impractical assessment courses offered to preservice teachers in their universities. Also, they had recurrently failed to put their limited assessment knowledge into practice. Despite this situation, they preferred to get basic rather than advanced assessment training due to personal and contextual constraints. The study bears implications for university English instructors, teacher educators, and university administrators.
O estudo dialógico da valoração
Authors: Pereira Rodrigo Acosta , Gregol Fernando Arthur
Published: February 2022

Neste trabalho, temos por objetivo apresentar uma discussão teórico-metodológica em torno do conceito de “valoração” e suas interfaces com outros conceitos da arquitetônica dos escritos de Mikhail Bakhtin e o Círculo. Para tanto, pautamos nossas discussões nas reflexões de Mikhail Bakhtin, Pável Medviédev e Valentin Volochínov e, ainda, em autores contemporâneos inseridos no campo de estudos da Análise Dialógica do Discurso (ADD). Trata-se, portanto, de uma pesquisa de revisão bibliográfica, pois buscamos delinear e revisitar caminhos de como o conceito de valoração é desenhado nos escritos do Círculo e em estudos contemporâneos da ADD. Os resultados apontam que a valoração, assim como o é com basicamente todos os conceitos da obra de M. Bakhtin e o Círculo, se engendra dialogicamente a outros conceitos cunhados pelo Círculo, tais como ideologia, cronotopo e esfera da atividade humana.
Comentários em fanfics
Authors: Mendonça Marina Célia , Lara Marina Totina de Almeida
Published: February 2022

Este artigo tem como objetivo analisar a relação de alteridade, a partir da proposta bakhtiniana, em comentários de leitores a fanfics publicadas no site brasileiro Spirit Fanfics e Histórias. A fanfiction é uma história de ficção escrita individual ou coletivamente a partir de livros, séries, filmes e/ou personagens de outros autores, sendo majoritariamente popular entre leitores e escritores jovens. Esses textos circulam na internet, em comunidades específicas – sites criados com esse fito, como o selecionado – e, nesse espaço de produção escrita, escritores e leitores dialogam sobre as produções, por meio dos comentários, no intuito de aperfeiçoá-las, sob os valores desse espaço. Para isso, o ato de comentar a produção do outro, manifestando seu posicionamento individual, a fim de colaborar com o desenvolvimento do texto, é fundamental e, por isso, é requerido pelos escritores e pelo próprio site. Os estudos bakhtinianos indicam que os enunciados concretos – manifestações de linguagem em atos/eventos interativos – são elaborados por sujeitos sociais sempre na relação com o outro, a quem se dirige, direta ou indiretamente. Assim, embasado pelos estudos de Bakhtin, de Volóchinov e da Análise Dialógica do Discurso, este trabalho analisa as relações de alteridade em cinco comentários postados em fanfics do seriado 13 Reasons Why, selecionados de um conjunto de 120, os quais compõem uma pesquisa de doutoramento em andamento, na qual o critério de seleção foi a presença de elogio/crítica justificada ao texto. Por sua vez, os comentários analisados neste artigo são representativos da alteridade nesse corpus maior. A metodologia selecionada – o cotejamento – consiste no colocar textos em relação, no intuito de ampliar os contextos para a compreensão dos enunciados, conforme propõe Bakhtin. Da proposta bakhtiniana, destacamos os conceitos de arquitetônica, diálogo, enunciado concreto, campo de atividade e alteridade como relevantes para a presente discussão, os quais embasam as análises propostas. Partiu-se da hipótese de que as relações de alteridade são elemento central para a edificação desses textos nessa comunidade colaborativa de produção escrita. Diante disso, os resultados alcançados indicam que o comentário é constituinte da fanfic, o qual orienta a produção com base na relação de alteridade entre autores e leitores. Somado a isso, o artigo destaca a importância do gênero comentário para essa relação, o qual se mostrou, por meio das análises, como singular nesse espaço, com as relações entre eu e outro marcadas em sua arquitetônica. Com isso, este artigo contribui para a área dos estudos bakhtinianos com considerações sobre os gêneros do discurso em contexto digital.
Sermões evangélicos e idealização do comportamento feminino
Authors: Santos Nádson Araújo dos , Petrus Wilton , Pugina Rosana Letícia
Published: February 2022

Este artigo teve como objetivo analisar a voz de autoridade do terceiro no discurso em sermões de pastores evangélicos quanto à presença de um ideário de submissão feminina com vista a problematizar o lugar e o papel da mulher na sociedade. Tratou-se de uma pesquisa qualitativa, do tipo estudo exploratório, em que foram analisados três vídeos disponibilizados na internet e textos bíblicos utilizados como voz de autoridade que dita regras acerca da condição da mulher. A metodologia caracterizou-se pela análise dialógica do discurso, por meio da qual se buscou perceber, a partir dos sermões, como os pastores pensam a construção social do lugar de mulher, atendendo aos preceitos bíblicos da fé cristã pentecostal e neopentecostal. Para isso, foram utilizadas as reflexões de Bakhtin (2011) e Volóchinov (2017) sobre discurso e os apontamentos de Beauvoir (1967) a respeito dos enquadramentos de gênero. Os resultados da análise demonstraram que o funcionamento da engrenagem patriarcal depende da obediência e submissão das mulheres evangélicas, dentro e fora das igrejas.
Persepsi Mahasiswa Jurnalistik pada Keterampilan Komunikasi Lisan Presenter Najwa Shihab
Authors: Maesyaroh Imas , Wibawa Darajat , Dulwahab Encep
Published: February 2022

Penelitian ini bertujuan untuk mengetahui persepsi atau pandangan mahasiswa Jurnalistik UIN Bandung pada keterampilan komunikasi lisan presenter Najwa Shihab. Penelitian ini menggunakan pendekatan kualitatif, metode penelitian pada penelitian ini adalah metode deskriptif yang memaparkan suatu situasi atau peristiwa berdasarkan data dari hasil wawancara. Metode ini digunakan agar mengetahui persepsi atau pandangan mahasiswa pada keterampilan komunikasi lisan presenter Najwa Shihab. Hasil penelitian menunjukkan bahwa pandangan mahasiswa terhadap keterampilan komunikasi Najwa Shihab menimbulkan persepsi yang positif. Keterampilan komunikasi Najwa Shihab saat membawakan sebuah acara dan menyampaikan informasi mampu membentuk pemahaman mahasiswa akan isi pesan yang disampaikan. Keterampilan komunikasi yang dimiliki Najwa Shihab sesuai dengan konsep dari Asrori yang meliputi keterampilan dalam menggunakan kata-kata/bahasa/gaya bahasa yang menarik dan sopan, dan mampu menjadi pendengar yang baik bagi narasumber maupun audiens dalam sebuah acara talkshow.

Kata Kunci ;  Persepsi; Keterampilan Komunikasi;

This research aims to find out the perceptions of views of UIN Bandung Journalistic students on the presenter’s oral communication skills, Najwa Shihab. This study uses a qualitative approach, the research method of this study is a descriptive method that describes a situation or event based on data from interviews. This method is used to determine the perceptions or views of students on the presenter's oral communication skills, Najwa Shihab. The results of the study show that students' views on the presenter's communication skills Najwa Shihab rise up the positive perceptions. Najwa Shihab's communication skills when delivering an event and delivering information were able to create students' understanding of the contents of the message delivered. The communication skills possessed by Najwa Shihab are in accordance with the concepts of Asrori which include skills in using interesting and polite words, languages and language styles, as well as are able to become good listeners for the speakers and audiences in a talkshow.

Keywords ; Perception; Communication Skills;
The Role of Social Media Da'wah in Improving Individual Piety during the Covid 19 Pandemic
Authors: Nuraeni Heni Ani , Kurniasih Novie
Published: February 2022

This study aims to analyze the use of social media as a da'wah platform during the covid 19 pandemic. The research is directed at observing the role of social media da'wah in increasing individual piety. This study uses a qualitative approach through descriptive methods. Descriptive research is research whose purpose is to present a complete picture of exploration and clarification of a phenomenon. Data were collected through observation, interviews, and distributing questionnaires via a google form. The subjects in this research are women aged 30-60 years who live in Jakarta and are active social media users. The results show that social media can increase knowledge, sources of information, communication and increase individual piety. The increase in individual piety is marked by the dominance of access to religious content during the COVID-19 pandemic. In addition, religious content that many users access is related to worship, such as prayer, zakat, infak and alms, fasting, hajj, and reading the Qur'an. Individual piety becomes an immunity that strengthens self-confidence and capital in building social piety.
Miracles, Offerings, Aspirations and Predictions
Authors: Appleton Naomi
Published: February 2022

Part A of the volume introduces the Avadānaśataka and its themes and concerns, with a particular focus on placing the first four chapters of the text – those translated in Part B of the volume – into the context of developing ideas about the Buddha and buddhahood. After a general introduction to the text, the discussion moves through themes that are core to each of the chapters under discussion: the many buddhas of the past and future who feature in chapters 1 and 2; the past lives of the most recent Buddha, Śākyamuni, which are related in chapters 2 and 4; and the pratyekabuddhas (beings awakened in times of no Buddhism) of chapter 3. The discussion then uses features common to the whole text, including miracles, aspirations and predictions, to mount an argument that the Avadānaśataka treads a fine line between acknowledging the validity of the three paths to awakening (full buddhahood, pratyekabuddhahood and arhatship) while clearly placing full buddhahood at the pinnacle. Furthermore, even within the category of full buddhas, Śākyamuni Buddha takes centre stage as the miracle-working, prediction-making, magical-smiling, utterly awe-inspiring Buddha of our time.
Assessment of visceral adipose tissue in patients with coronary artery disease using bioelectrical impedance analysis
Authors: Miklishanskaya S. V. , Orlovsky A. A. , Chigineva V. V. , Karlova N. A. , Muksinova M. D. , Mazur N. A.
Published: February 2022

Aim. To study visceral adipose tissue (VAT) content in patients with coronary artery disease (CAD) using the bioimpedance analysis, to identify metabolic disorders associated with visceral obesity, and to determine the role of individual risk factors in the formation of coronary artery lesions using modern statistical methods.

Material and methods. A total of 152 patients were examined (women, 66; men, 86). The median age of patients was 63 [55;69] years. This observational study assessed anthropometric parameters, such as height, weight, body mass index, waist circumference, whole-body fat percentage, and specifically VAT mass, as well as the relationship of these parameters with blood levels of triglycerides, high-density lipoprotein cholesterol (HDL-C) and glucose. Height was measured using a metal height meter RM-1 “Diakoms”. Weight, body mass index, wholebody fat percentage, and VAT mass were measured using the Omron BF-508 body composition monitor (Omron, Japan). Epicardial adipose tissue (EAT) thickness was assessed using two-dimensional echocardiography on a Philips Sonos 5500 ultrasound system (Germany).

Results. Bioimpedance analysis revealed a higher VAT content in patients with CAD compared with those without CAD (14 [11;18]% vs 13 [10;14,5]%, respectively (p=0,025)). During the ROC analysis, cut-off values for VAT ≥15% and EAT ≥7,5 mm were identified, associated with a higher risk of CAD. In multivariate analysis, only HDL-C levels were significantly associated with CAD, while at the same time, univariate analysis demonstrated the significance of VAT and EAT in predicting CAD.

Conclusion. The results showed that an increased VAT content and low HDL-C level is associated with the presence of CAD.
Myocardial revascularization by percutaneous coronary intervention in senile patients with chronic total occlusion: a modern view of the problem
Authors: Atamanyuk E. R. , Tarasov R. S. , Tyryshkin A. G.
Published: February 2022

In recent decades, the problem of coronary artery disease (CAD) accompanied by chronic total occlusion (CTO) has come to the fore in senile patients. The reason for this is the absence of generally accepted management strategies for these groups of patients. The choice of myocardial revascularization method in elderly patients has a fundamental impact on outcomes, but requires additional research. There is no doubt that in recent years, percutaneous coronary intervention (PCI) in CTO has gained a status as the first-choice method for this pathology. The following main reasons are distinguished: development of intravascular imaging; improvement of surgical instruments; development of new approaches to recanalization; increase in the number of experienced surgeons. The use of PCI for CTO in elderly patients is specified by the upward trend in the proportion of senile population worldwide. This review considers the validity and potential of using PCI for CTO in senile patients, as well as its safety, benefits and prospects. For this review, the following databases were used: Medline (PubMed), RSCI (eLIBRARY), Google Scholar.
Anthropometric indices and their relationship with poor prognosis in patients with coronary artery disease and obesity
Authors: Svarovskaya A. V. , Trubacheva O. A. , Pereverzev S. V. , Garganeeva A. A.
Published: February 2022

Aim. To assess the association of anthropometric indices in patients with coronary artery disease (CAD) and obesity and to study their predictive value in the development of adverse cardiovascular events.

Material and methods. The study included 229 patients with CAD (median age, 55±7,56 years). Depending on the presence of obesity according to the World Health Organization criteria (1999), patients were divided into 2 groups. The 1st group included 107 obese patients, while the 2nd group — those without obesity (n=122). The groups were comparable in age. We measured waist (WC) and hip circumference (HC), followed by waist-to-hip ratio and body mass index calculation. The lipid profile parameters were determined by the enzymatic colorimetric method. During the study, the following indices were calculated: body mass index, visceral adiposity index, insulin resistance index, body shape index (BSI), fasting triglyceride (TG)/plasma glucose index, waist-to-height ratio, lipid accumulation product, TG-to-high density lipoprotein cholesterol ratio.

Results. During the follow-up period, adverse cardiovascular events in the 1st group of patients were found in 37 (34,5%) patients, while in the 2nd group, the composite endpoint was revealed in 12,3% of patients. In order to develop a model for predicting the risk of an unfavorable CAD course in obese patients, we performed a logistic regression analysis, which showed that the following were the most significant predictors of unfavorable cardiovascular outcomes: TG/glucose index and BSI.

Conclusion. Thus, of all the considered anthropometric indices, only two were associated with unfavorable CAD course — TG/glucose index and BSI. The data obtained indicate the validity of the search for novel useful obesity indicators with a good predictive value.
CASA: Conversational Aspect Sentiment Analysis for Dialogue Understanding
Authors: Song Linfeng , Xin Chunlei , Lai Shaopeng , Wang Ante , Su Jinsong , Xu Kun
Published: February 2022

Dialogue understanding has always been a bottleneck for many conversational tasks, such as dialogue response generation and conversational question answering. To expedite the progress in this area, we introduce the task of conversational aspect sentiment analysis (CASA) that can provide useful fine-grained sentiment information for dialogue understanding and planning. Overall, this task extends the standard aspect-based sentiment analysis to the conversational scenario with several major adaptations. To aid the training and evaluation of data-driven methods, we annotate 3,000 chit-chat dialogues (27,198 sentences) with fine-grained sentiment information, including all sentiment expressions, their polarities and the corresponding target mentions. We also annotate an out-of-domain test set of 200 dialogues for robustness evaluation. Besides, we develop multiple baselines based on either pretrained BERT or self-attention for preliminary study. Experimental results show that our BERT-based model has strong performances for both in-domain and out-of-domain datasets, and thorough analysis indicates several potential directions for further improvements.
MULTI-OBJECTIVE OPTIMIZATION OF AN AMMONIA-BASED MULTI-STAGE VAPOR COMPRESSION REFRIGERATION SYSTEM WITH FLASH INTERCOOLER CUM SUBCOOLER
Authors: Singh Kaushalendra Kumar , Kumar Rajesh , Gupta Anjana
Published: February 2022

This work focuses on multi-objective optimization of an ammonia-based multi-stage vapor compression refrigeration system incorporated with a flash intercooler which also works as a sub-cooler. The study is carried out via thermo-economic optimization of the system in order to maximize the exergetic efficiency and minimize the total capital cost of the system. Evaporator temperature, condenser temperature, subcooling parameter, and de-superheating parameter are considered as the four design variables of optimization problem. Multi-objective Genetic Algorithm (MOGA) is employed to carry out the optimization using MATLAB. The technique for order of preference to by similarity to ideal solution (TOPSIS) decision-making technique has been used to find unique solutions for five different weights of exergetic efficiency and total cost. The results reveal that exergetic efficiency and total capital cost of the system are 41.76% and 223,717.6 USD, respectively, at thermo-economic optimal operating conditions.
Qualitative Assessment of Access to Perinatal Mental Health Care: A Social-Ecological Framework of Barriers
Authors: Tyokighir Deborah , Hervey Ashley , Schunn Christy , Clifford Daniel , Ahlers-Schmidt Caroyln
Published: February 2022

Introduction. Psychological distress affects up to 25% of pregnant women and contributes to poor birth outcomes. This project aimed to triangulate themes from interviews with low-income pregnant or postpartum women, primary care providers and mental health providers regarding knowledge of and barriers to mental health services in the perinatal period.
Methods. Study personnel conducted interviews in Sedgwick County, Kansas until saturation of themes within each group. Thirty-three interviews were transcribed, independently reviewed using grounded theory and themes were stratified using the social-ecological model framework.
Results. Individual level themes including cost/lack of insurance and transportation were consistent across groups, however women only identified barriers at this level. Consistent themes across provider groups included lack of support at the interpersonal level; poor communication between providers at the organizational level; and Medicaid limitations at the public policy level.
Conclusions. Multi-level interventions are needed to improve access to mental health care for low-income women in the perinatal period.
EVALUATION OF ENDOGENOUS AUDITORY EVOKED POTENTIALS IN CHILDREN WITH SPECIFIC LANGUAGE IMPAIRMENT: A REVIEW
Authors: Prabhu Prashanth , Vastare Guruprasad Mekhala , Vijayan Kavya , Narayanan Swapna , Barman Animesh
Published: February 2022

Introduction

Children with specific language impairment (SLI) have poorer language ability and have difficulties understanding complex sentences even though they have no clear sensory, motor, or neurological abnormalities. Nevertheless, they may exhibit auditory processing deficits. Hence the present study was conducted to provide an overview of endogenous auditory evoked potentials in this population, potentials which may help in early identification of subtle auditory processing deficits.

Material and Methods

Relevant articles were included from searches of two electronic data sources, Google Scholar and PubMed. Articles on endogenous potentials in children with SLI were included, but studies on exogenous potentials in children with SLI were excluded.

Results

The results of the review showed contradictory findings in terms of mismatch negativity. Some studies report a statistically significant difference in waveform morphology, latency, and amplitude of mismatch negativity between children with SLI and a control group. This suggests that these children might have auditory processing problems at higher auditory centers. A few other studies find no difference in evoked potentials, pointing to intact auditory processing abilities in children with SLI.

Conclusions

The study helps us understand auditory processing abilities at the level of the higher auditory areas. Endogenous potentials may be included in a battery of tests for identifying children with SLI.
APPLICATIONS OF ARTIFICIAL INTELLIGENCE IN HEARING AIDS AND AUDITORY IMPLANTS: A SHORT REVIEW
Authors: Umashankar Abishek , MN Anusha , C Pachaiappan
Published: February 2022

Artificial intelligence (AI) has been broadly used for a long time, but in terms of hearing aids it only came into the limelight in 2004. Although at that time AI was yet to be incorporated into a hearing aid, with improvement in technology, slowly AI began to be introduced. AI included trainable hearing aids, own voice processing, brain-controlled hearing aids, strategies to improve speech perception in noise, and wind noise management in both hearing aids and cochlear implants. This short review discusses these AI technologies and their utility for the user.
ASSESSMENT OF THE CLINICAL UTILITY OF THE SENTENCE IDENTIFICATION TEST IN KANNADA FOR ADULTS
Authors: Chinnaraj Geetha , Sharath Kumar Keelara , Manjula Puttabasappa , Pavan Mahadevaiah
Published: February 2022

Introduction

A sentence identification test was developed by Geetha, Kumar, Manjula, and Pavan (2014) in the Kannada language. The test consists of 25 equivalent sentence lists with 10 sentences each. The present study aimed to assess the clinical utility of this test.

Material and methods

All sentences were presented to 5 groups of adults with 10 individuals in each group. Four groups, each of 10 individuals, had hearing loss: mild, moderate, moderately-severe, or severe. The fifth group had 40 individuals with normal hearing sensitivity. Standardized lists of 25 sentences were presented monaurally at the most comfortable level in a sound-treated double room. The number of correctly identified words was tabulated.

Results

The mean identification scores decreased with increase in the degree of hearing loss, although the scores were comparable between the normal and mild group. A comparison of scores between each list within each group revealed that there was no significant difference between the lists for the scores obtained from the individuals with mild, moderate, moderately-severe, and severe degrees of hearing loss.

Conclusions

The developed sentence material is sensitive to differences in speech identification ability across different degrees of hearing loss. In addition, the mean number of correctly identified words do not vary across the lists in any of the four groups, suggesting equivalency across the standardized 25 lists in the clinical groups.
PRODUKSI BIOETANOL DARI BAGAS SORGUM MANIS MELALUI SAKARIFIKASI DAN FERMENTASI SIMULTAN (SSF) KONVENSIONAL MENGGUNAKAN Trichoderma reesei dan Saccharomyces cerevisiae
Authors: Syadiah Essa Annisa , Syamsu Khaswar
Published: February 2022

Bagas sorgum manis (Sorghum bicolor L. Moench) merupakan hasil samping industri gula dari nira sorgum manis yang dapat digunakan sebagai bahan baku pembuatan bioetanol. Tujuan dari penelitian ini adalah untuk memproduksi bioetanol dari bagas sorgum manis menggunakan Trichoderma reesei dan Saccharomyces cerevisiae. Teknik Sakarifikasi dan Fermentasi Simultan (SSF) konvensional adalah teknik SSF produksi bioetanol dengan aerasi penuh atau tidak direkayasa. Penggunaan teknik SSF memiliki kelebihan jika dibandingkan dengan teknik sakarifikasi dan fermentasi terpisah (SHF), yaitu waktu proses produksi yang dibutuhkan lebih pendek, meningkatkan rendemen, dan laju produksi bioetanol. Produk bioetanol akhir yang dihasilkan sebesar 6.60±0.28 g L-1. Dengan μx maks gabungan sebesar 0.02/jam, nilai Yp/s sebesar 0.17±0.01 g bioetanol/g substrat, dan laju produksi bioetanol sebesar 0.09±0.00 g L-1 jam-1.
PERSEPSI KONSUMEN REMAJA DI KOTA BANDUNG TERHADAP PRODUK PANCAKE BAYAM
Authors: Andriastuti Primasti Alya , Rahayu Dwi Lestari
Published: February 2022

Kesehatan merupakan aspek yang penting dalam menjalani kehidupan. Salah satu usaha untuk menjalankan hidup sehat adalah dengan mengonsumsi makanan bergizi. Pancake bayam dapat menjadi alternatif makanan ringan yang sehat dan merupakan produk makanan ringan yang inovatif. Oleh karenanya, penelitian ini bertujuan untuk mengetahui persepsi konsumen terhadap produkpancake bayam. Metode yang digunakan dalam penelitian ini adalah metode deskriptif kuantitatif yang melibatkan 170 responden berusia 17-21 tahun yang berdomisili di Bandung. Persepsi konsumen merujuk pada atribut-atribut yang meliputi kesehatan, kualitas, harga, ramah lingkungan, dan food safety. Secara keseluruhan, hasil penelitian menunjukkan bahwa responden memiliki persepsi yang baik terhadap produk pancake bayam, namun jika dilihat dari 5 atribut yang digunakan, atribut food safety memiliki persepsi yang sangat baik sedangkan yang lainnya baik. Atribut kualitas memiliki skor nilai persepsi yang paling rendah dibandingkan atribut yang lain, oleh karenanya atribut ini perlu diperbaiki untuk mewujudkan persepsi yang lebih baik lagi.
KARAKTERISTIK MUTU KIMIA DAN BIOLOGI COCOGURT DENGAN PERBEDAAN KONSENTRASI PEKTIN DAN PISANG SEBAGAI PREBIOTIK ALAMI
Authors: Destiana Irna Dwi , Aprilia Devi , Hermalia Sri
Published: February 2022

Cocogurt atau coconut yoghurt merupakan minuman probiotik berbahan dasar susu atau santan kelapa yang difermentasi dengan bantuan bakteri asam laktat (BAL). Penambahan pisang berperan sebagai prebiotik fasilitator bakteri asam laktat, sedangkan pektin untuk memperbaiki tekstur. Penelitian ini bertujuan untuk mengetahui pengaruh perbedaan penambahan konsentrasi pisang dan pektin terhadap karakteristik mutu kimia dan biologi cocogurt. Sampel yang diamati adalah 3 formulasi terbaik yang diperoleh dari 16 formulasi hasil penelitian sebelumnya. Hasil pengukuran dan analisis sidik ragam dengan alfa 5% dilanjutkan dengan Uji Duncan Multiple (DMRT) dengan selang kepercayaan 5%. Penambahan perbedaan konsentrasi prebiotik memberikan pengaruh nyata terhadap kadar lemak dan total bakteri asam laktat, namun penambahan perbedaan konsentrasi pisang dan pektin tidak berpengaruh nyata terhadap kadar abu dan kadar protein. Penambahan pisang berbanding terbalik dengan kadar protein, namun berbanding lurus dengan total bakteri asam laktat.
Was passiert in Druckbehältern zur Druckstoßsicherung?
Authors: Haakh Frieder
Published: February 2022

Bei der Auswertung von Kompressions- und Dekompressionsversuchen an Druckbehältern zur Druckstoßsicherung wurde festgestellt, dass sich im Druckbehälter eine deutliche Temperaturschichtung einstellt. Weiterhin zeigt die Analyse der Messwerte, dass eine hinreichend genaue Beschreibung der Zustandsänderung gelingt, wenn in der Zustandsgleichung der Anteil des Wasserdampfes im Druckluftpolster sowie die Enthalpieänderung von Luft und Wasserdampf berücksichtigt werden. Erst damit kann die Wärmebilanz zur Bestimmung des Wärmeübergangskoeffizienten zutreffend aufgestellt werden. Der vorliegende Beitrag erläutert die Zusammenhänge anhand von Versuchsdaten an realen Druckbehältern sowie die weitergehenden Auswertungen.
Tension headache treatment
Authors: Yakupova A. A. , Ismagilov M. F. , Yakupov R. A.
Published: February 2022

Among the variety of different types of headaches, the leading place (more than 80%) belongs to tension-type headache (THT), the frequency of which in the population ranges from 32 to 64%. Treatment of HDN is a rather difficult task. This is primarily due to the need to carefully consider all the mechanisms of the development of the pathological process in various types of HDN, as well as additional factors (cervicogenic, myofascial, psychoalgic, etc.) leading to the onset of pain.
Software quality revisted
Authors:   , Haigh Maria , Verner June
Published: February 2022

This work presents an exploratory study of the differences in software quality perceptions between different groups of people involved with the software development process. Survey respondents ranked each of thirteen generally accepted attributes of software quality on a scale of one to seven according to their perceived importance for the piece of software most vital to that individual's work: correctness, maintainability, usability, testability, flexibility, portability, reusability, interoperability, integrity, accuracy, robustness, augmentability, efficiency. Differences in the priorities assigned to these attributes were explored using a number of different statistical techniques. The main category of analysis is termed here the "stakeholder role" of the individual with respect to the chosen software, and consists of two dimensions: managerial/non-managerial and development/use. The four primary categories were thus termed developer, development manager, user and user manager. Several additional ways of grouping the individual respondents were explored. Firstly, the organizational sector in which the respondent works (education, military, etc.) was used. Secondly, the class of software (custom developed corporate application, standard mass market package, etc.) was analyzed. Thirdly, the overall view of the nature of quality, according to the taxonomy established by Garvin, was examined. Finally, other personal characteristics of the respondent, including their general interest in software quality issues and years of experience with the software development process, were explored. This study, which including the pilot data examined the responses of almost seven hundred individuals, found that ideas of what constituted software quality were broadly shared between different stakeholder groups. This reassuring finding suggests that software which can achieve high levels of quality according to the attributes valued by all groups, such as correctness and accuracy, will be viewed as satisfactory by all stakeholder groups. The survey did reveal important differences between the priorities assigned to a number of attributes by holders of different roles, particularly usability (favored by users) and testability and maintainability (favored by development staff).
New approaches to the state accreditation procedure: accreditation indicators - areas for improvement
Authors: Горячко В.В. , Зернов В.А. , Дарда И.В.
Published: February 2022

Рассматриваются изменения, которые произойдут в процедуре государственной аккредитации с марта 2022 года. Выделяются положительные моменты и возможные проблемы. Анализируются показатели и критерии их оценки.

The changes that will occur in the state accreditation procedure from March 2022 are being considered. The positive aspects and possible problems are highlighted. The indicators and criteria for their evaluation are analyzed.
Accompanying students of pedagogical areas of training in the process of practice
Authors: Неумоева-Колчеданцева Е В , Болтунова Л.М.
Published: February 2022

Рассматриваются теоретические аспекты психолого-педагогического сопровождения будущих педагогов в процессе практики. Сопровождение трактуется как интегративная педагогическая деятельность. Анализируется содержание психолого-педагогического сопровождения на разных этапах взаимодействия студентов с образовательной средой.

The theoretical aspects of psychological and pedagogical support of future teachers in the process of practice are considered. Accompanying is viewed as an integrative pedagogical activity. The content of psychological and pedagogical support at diff erent stages of interaction between the individual and the educational environment is analyzed.
Stages of preparation of future teachers-defectologists for professional activities
Authors: Бекирова М.И.
Published: February 2022

Рассматривается проблема подготовки будущих учителей-дефектологов к профессиональной деятельности в процессе обучения в высшем учебном заведении. Подготовка специалистов представлена как взаимосвязанный процесс, включающий определенные этапы (мотивационный, деятельностный, рефлексивный), соблюдение последовательности которых позволит повысить уровень подготовленности обучающихся к профессиональной деятельности. Проблема рассматривается на примере направления подготовки 44.03.03 Специальное (дефектологическое) образование, профиль «Олигофренопедагогика», программы авторского специального курса.

The article deals with the problem of preparing future teachers-defectologists for professional activity as a result of training in a higher educational institution. The training of specialists is presented as an interconnected process that includes certain stages (motivational, activity, refl exive), the observance of which will increase the level of preparedness of students for professional activities. The problem is considered on the example of the direction of training 44.03.03 Special (Defectology) Education, profi le «Oligophrenopedagogy».