bluuebunny/crossref_metadata_2025 huggingface dataset:
Organellar crosstalk as a potential therapeutic target for rare neurodegenerative diseases
Authors: Lam Josephine J. , Li Chenxu , Terluk Marcia R. , Kartha Reena V.
Published: February 2025

Organellar crosstalk has gained significant interest due to its essential role in maintaining cellular homeostasis and normal function. Conversely, disruptions in organelles and their interactions are increasingly recognized as key contributors to the pathogenesis of numerous diseases. Rare neurodegenerative diseases, such as Gaucher disease (GD) and X-linked adrenoleukodystrophy (ALD), are caused by inherited mutations that disrupt critical metabolic pathways. Genetic variants encoding key proteins involved in these pathways result in the excessive accumulation of corresponding substrates, which subsequently trigger organellar crosstalk dysfunction, often involving mitochondria, lysosomes, endoplasmic reticulum (ER), or peroxisomes. To date, the specific mechanisms underlying organellar interactions and their roles in the pathophysiology of these respective diseases are not fully elucidated, an area that continues to be actively studied. Understanding these mechanisms could reveal novel pathways or targets for future therapeutic development. Furthermore, the severity of these rare neurodegenerative diseases and the lack of effective treatments forpatients underscore the urgency for thorough investigations into organellar crosstalk. This review provides an overview of the crosstalk between mitochondria, lysosomes, the ER, and peroxisomes in lysosomal diseases, such as GD, and peroxisomal disorders, including ALD. Additionally, we explore potential therapeutic strategies targeting these interconnected pathways.
Turkey in Cenral Asia: Regional Trends
Authors: Sbitneva A.
Published: February 2025

The Turkic direction, in particular the Central Asian region, is not new for the foreign policy of the Turkish Republic, which has been systematically expanding its influence there since the collapse of the Soviet Union and forming a special subsystem of international relations called the “Turkic world”. Over the past few years, the forms of Turkey's interaction with the Turkic-speaking space have dramatically changed. Currently, in Turkey’s regional Central Asian policy can be traced 4 trends, which in the midterm can significantly reform both: the region and individual countries in particular. Among these trends are: the informatization and Latinization of the “Turkic world”, the intensification of contacts with neutral Turkmenistan and the formation of the foundations of Turkic-centric security.
Socio-political Adaptation of Belarus to Regional Realities
Authors: Olenchenko V.
Published: February 2025

The changes taking place in the region and in the world require Belarus to clarify its ideology. Belarus is experiencing a multi-vector ideological impact. The article analyzes the main factors of influence. The method of research is a comparison of external and internal factors. The question of the ideology of the Union State has been raised. The analysis shows that cooperation with Russia, primarily within the framework of the Union State, continues to be the key to the sovereignty of Belarus and the preservation of its identity. A joint Russian-Belarusian study of the possibilities of ideological strengthening of the Union State is becoming urgent. More broadly, a conceptual and practical revision of the main approaches of Russia and Belarus to key points of global development is needed.
Optimalisasi Pengelolaan Bisnis untuk Kemajuan Ekonomi Lokal: Analisis SWOT pada Angkringan Asli Jogja, Kota Batu
Authors: Rahayu Nika Esti , Ibrahim Rosida , Primasiwi Asri
Published: February 2025

This community service activity aims to analyze and provide strategic recommendations for optimizing MSME business management based on SWOT analysis. This community service was carried out on October 1-31, 2024 at Angkringan Asli Jogja, Batu City. The method used is discussion and mentoring with 6 stages of activities. This community service has resulted in the original Angkringan of Jogja having the potential for strengths in the form of an experienced and trained team, a varied and affordable menu and an efficient operational process. The weaknesses in this angkringan are the limited number of employees, product innovation that is still lacking, and financial management that is not optimal. Angkringan Asli Jogja has opportunities, namely increasing interest in local culinary and consumer trends that prioritize cheap food and culinary experiences. The threats that need to be considered for this angkringan are fierce competition in the culinary sector and rapid changes in consumer tastes. Based on the results of the satisfaction survey for this activity, it was obtained that 61% of the participants were very satisfied with the delivery of the material and the relevance of the strategic recommendations to the conditions of MSMEs, while 39% of the participants were satisfied with the Community Service activities carried out.
Digital Skills Workshop for Adult: Mastering the Basics of Technology in the Digital Age
Authors: Hera Khairunnisa  , Zairin Gentiga Muhammad , Saparuddin Mukhtar  , Wahono Puji , Muhammad Edo Suryawan Siregar  , Shandy Aditya  , Anisa Putri Isnaini  , Dwi Handarini  , Charlie Albert Lasuin
Published: February 2025

This program aimed to enhance digital awareness and literacy by equipping participants with essential knowledge and skills in navigating the digital environment. The webinar, held on July 15, 2024, attracted 80 participants, including students, lecturers, and the general public from Jakarta State University and Universiti Malaysia Sabah. Expert speakers addressed critical topics such as maintaining human connection in the digital age (Charlie Albert Lasuin, Universiti Malaysia Sabah), responsible data collection for economists (Prof. Dr. Puji Wahono, S.E., M.Sc., Jakarta State University), and the interplay between social media and data privacy (Shandy Aditya, Jakarta State University). The program successfully engaged participants, sparking active discussion and a desire for further learning in digital and social literacy.
Study on Effects of Bending Stiffness of Aluminum Alloy Plate-Column Joints on Stability of Semi-Rigid Single-Layer Cylindrical Reticulated Shells
Authors: LI Ren , LI Huijun , XIAO Zhicheng , LI Baohui
Published: February 2025

The plate-column joint (PCJ) is a kind of typical semi-rigid joint improved from traditional plate joint and has larger bending stiffness. The influence of the geometric parameters of the joint on its bending stiffness and the stability of its semi-rigid reticulated shell has not been well-clarified. For this reason, this study first investigates the influence of the cover plate thickness and bolt diameter on the joint bending stiffness and then obtains the bending moment-rotation angle curves. Secondly, an improved bilinear model (i.e. bending moment-rotation angle) is proposed, and the fitting formulas of the stiffness coefficient, initial stiffness and yield bending moment of the bilinear model are formulated by a multiple regression analysis. Finally, the influence of the cover plate thickness on the bearing capacity of single-layer cylindrical reticulated shells with different spans and rise-to-span ratios is figured out. The results showed that the smaller the cover plate thickness, the smaller the bearing capacity of reticulated shell. When the thickness of the cover plate is less than 4 mm, the bending stiffness decreases significantly. Therefore, the cover plate thickness can be taken as 4-6mm to save steel consumption. Furthermore, bending stiffness of the joint has a significant effect on the failure mode of the reticulated shell.
A chronological history of fetal pain during prenatal surgery
Authors: Bellieni Carlo V.
Published: February 2025

Much debate still exists on fetal pain, and this is often due to the scarcity of trials on this topic. This review reports the history of this debate since its origins, which dates back to about 50 years. Understanding this trajectory is important to identify the points that are clear now, the way a consensus was reached on them, and the aspects that still require clarification. Until now, no scheme is available to summarize the scientific progress in this field. This article aims to offer such a scheme, as well as raise further questions to delve deeper in future research.
Conceptions of Physiotherapy students about concepts in the field of Gender and Sexuality
Authors: Félix Viviane Patrícia Pereira , Silva Ivanderson Pereira da
Published: February 2025

This article was developed based on a study conducted in the context of the Embryology curricular component taught in the first year of the Physiotherapy course at a public university in Maceió, AL. Its general objective was to investigate the senses and meanings that Physiotherapy students attribute to concepts in the field of Gender and Sexuality. This is an action research, whose data analysis was based on the assumptions of content analysis. The research presented as a potential attempt to deconstruct the discourses that reinforce standardizations and naturalization present in Embryology classes. Finally, as limiting factors, we highlight the short discussion time and the marginality of the themes.
Financing Risk Mitigation Strategy with Governance Approach, Local Wisdom, and Religiosity at Sharia Rural Bank (BPRS) of Riau
Authors: Putra P. Adiyes , Sapparudin Sapparudin , Anggraeni Tuti , Nurnasrina Nurnasrina
Published: February 2025

This study presents an innovative approach to financing risk mitigation strategies at BPRS in Riau by identifying causal factors, solutions, and strategies. Using a qualitative approach with the Analytic Network Process (ANP) method involving regulators, practitioners, and academics to reveal the interconnection between internal and external factors, sociocultural dimensions, and religiosity affecting financing performance. The findings show that implementing good governance, community and local wisdom, and religious values in the customer selection process reduces financing risks and strengthens the relationship between Sharia Rural Bank (BPRS) and the community. The results of this study provide significant contributions to developing a more comprehensive and sustainable risk mitigation framework, policies, and practices for BPRS in Riau, inspire the application of similar principles in other Islamic financial institutions, and encourage regulators to develop regulations to support the development of BPRS.
Religiosity as a Moderator Between Planned Behavior Factors and Online Purchase Intention
Authors: Lahuri Setiawan Bin , Mulia Putri Nurmalasari , Ahmad Rusyda Afifah , Mahfudz Akhmad Affandi
Published: February 2025

The development of the digital era has changed consumer behavior patterns. This is influenced by factors such as social media, ease of use, lifestyle, and price. This study aims to evaluate the influence of social media, ease of use, price, lifestyle, and religiosity on online shopping behavior. This study uses Structural Equation Modeling (SEM) with a quantitative approach to measure the influence of social media, ease of use, price, lifestyle and religiosity on 300 Muslim consumer respondents with religiosity as a moderator variable. This study found that social media, ease of use, price, and lifestyle have a significant impact on online shopping behavior, with a p-value below 0.05. Price shows the strongest influence (coefficient 0.328), followed by ease of use (0.261), social media (0.219), and lifestyle (0.132). In contrast, religiosity has no significant influence (p-value 0.954) and does not moderate this relationship, as indicated by the high p-value and low f-square value. This suggests that Muslim consumers prioritize rational factors over religiosity in online shopping.
Partnership Morality as a Masterpiece of Business Performance
Authors: Ade Sinar Hubtriyan , Wibowo Bagus Yunianto , Kurniasih Pritha
Published: February 2025

Partnership morality strengthened by spiritual capital is a variable built to mediate the effect of relational capital on business performance. The main purpose of this research is to analyze the essence and role, partially focusing on relational capital, spiritual capital, and partnership morality in business performance. In this study, the population was the owner of Batik SMEs in Pekalongan, Central Java, Indonesia, with as many as 247 Batik business units. The sampling method employs census sampling or turns the entire population into a research sample using a purposive sampling technique. The sample in this study was 101 owners of Batik SMEs in Pekalongan. Structural Equation Modeling (SEM) was used to analyze the data. The results of this study proved that partnership morality strengthened by spiritual capital variables can become a powerful mediation in the effect of relational capital on business performance. Partially, relational and spiritual capital has a significant positive effect on partnership morality. Meanwhile, spiritual and moral capital has a positive and significant impact on business performance, while spiritual capital does not affect business performance.
CONSUMERS' BEHAVIOURAL INTENTION TO ADOPT SHARI’AH-COMPLIANT DIGITAL GOLD PLATFORM IN MALAYSIA: EXTENSION OF UTAUT MODEL
Authors: Hamdan Nur Hazirah binti , Kassim Salina binti , Nik Azman Nik Hadiyan , Abd Rahman Noor Amira Syazwani Binti
Published: February 2025

The advancement of technology has resulted in the emergence of digital platforms, such as digital gold platforms, as alternative channels for retail investment. In this study, we investigate factors that influence consumers’ behavioural intentions towards a Shari’ah-compliant digital gold platform in Malaysia. The study incorporates trust and Shari’ah-compliance as constructs in the extended UTAUT model. Gathering data from 130 respondents and applying SmartPLS 4.0 for data analysis, the study documents the significance of performance expectancy, effort expectancy, trust, and Shari’ah-compliance. Meanwhile, facilitating conditions and social influence turn out to be insignificant. The study notes that feeling safe, secure, and transparent as well as having Shari’ah-compliant features are crucial factors that influence consumer intention to adopt the Shari’ah-compliant digital gold platform in Malaysia. It is also critical to be aware of the services provided by Shari’ah-compliant providers and financial institutions by utilising the social network within the Shari’ah-compliant finance sphere.
PORTFOLIO DIVERSIFICATION OPPORTUNITIES FOR NIGERIA’S ISLAMIC (SHARIAH) STOCK INVESTORS WITH THEIR MAJOR TRADING PARTNERS
Authors: Abdulkarim Fatima Muhammad , Ali Hamisu Sadi , Muhammad Ibrahim Muye , Tabash Mosab I.
Published: February 2025

This paper investigates potential diversification opportunities for Nigeria’s Islamic stock investors with Nigeria’s top trading partners (France, Spain, United Kingdom and India). It employs daily data of Islamic stock indices, namely Nigeria’s LOTUS Islamic index and FTSE shariah indices of the four countries, from 14 July 2015 to 14 December 2022. Using multivariate GARCH-DCC, we show that Islamic investors from Nigeria have almost no portfolio diversification opportunities in the Islamic stock markets of these countries except for a slight portfolio diversification opportunity found in the UK Islamic stock market for a very short period (one year) and almost none for India, Spain, France. The results from the continuous wavelet transform (CWT) however suggest that diversification opportunities are present in UK, France, Spain and not in India. These findings have important policy implications for policy makers and investors seeking to invest in these countries to be mindful of the appropriate investment timing to minimize potential future losses in investments.
Impact of organic contents on sludge rheology and dewaterability
Authors: Tabatabaei Seyedali
Published: February 2025

Understanding the relationship between the rheological behaviour of digested sludge and its dewaterability is crucial for reducing the overall operating costs of the dewatering process. Municipal sewage sludge exhibits complex and unpredictable rheological properties due to its nature as a suspension containing various degradable and non-degradable organic matter, including extracellular polymeric substances (EPS). This study analyses the effect of different conditioning technologies on the non-degradable organic matter in sludge and their impact on dewatering performance and rheological behaviour. Since the change in characteristics of EPS (protein and polysaccharide) on different sludges rheology has not been investigated in previous works, this current investigation examines the effect of EPS characteristics on sludge rheology and subsequently on sludge dewaterability by characterising EPS compounds using Fourier Transform Infrared (FTIR). By examining sludge samples from various treatment plants, we aim to provide a comprehensive understanding of these effects.
Per- and polyfluoroalkyl substances (PFAS) degradation and defluorination involving ultraviolet and ultrasonication activated advanced oxidation and reduction
Authors: Wanninayake Dushanthi , Hamilton David , Yu Jimmy , Busch Andrew
Published: February 2025

Breaking down PFAS into their starting elements, or even naturally degradable products, is extremely difficult with most treatment techniques, thus developing an efficient and cost-effective treatment methodology would be an important breakthrough.

The objective of this research was to adapt currently available water treatment techniques for micropollutants for improving PFAS breakdown efficiency. We used low frequency ultrasonication (US) in the presence of oxidative and/or reducing agents, and with or without catalysts, to enhance PFAS degradation.
Inferring directed spectral information flow between mixed-frequency time series
Authors: Chen Zhe , Xian Qiqi
Published: February 2025

Identifying directed spectral information flow between multivariate time series is important for many applications in finance, climate, geophysics and neuroscience. Spectral Granger causality (SGC) is a prediction-based measure characterizing directed information flow at specific oscillatory frequencies. However, traditional vector autoregressive (VAR) approaches are insufficient to assess SGC when time series have mixed frequencies (MF) or are coupled by nonlinearity. Here we propose a time-frequency canonical correlation analysis approach (“MF-TFCCA”) to assess the strength and driving frequency of spectral information flow. We validate the approach with extensive computer simulations on MF time series under various interaction conditions and further assess statistical significance of the estimate with surrogate data. In various benchmark comparisons, MF-TFCCA consistently outperforms the traditional parametric MF-VAR model in both computational efficiency and detection accuracy, and recovers the dominant driving frequencies. We further apply MF-TFCCA to real-life finance, climate and neuroscience data. Our analysis framework provides an exploratory and computationally efficient nonparametric approach to quantify directed information flow between MF time series in the presence of complex and nonlinear interactions.
Motor skills and fitness in African children: the PERF-FIT study
Authors: Smits-Engelsman Bouwien , Coetzee Dane , Doe-Asinyo Rosemary , Ituen Oluwakemi , Farhat Faical , Dubale Yabsra , Verbecque Evi
Published: February 2025

Africa is facing an increasing prevalence of non-communicable diseases (NCDs) due to changing lifestyles and dietary habits. Children with developmental delays in motor coordination are particularly less inclined to engage in physical play and sports, putting them at risk of reduced fitness, overweight, and eventually NCDs. While several motor performance tests exist, they were not designed for African children and lack valid norms. As the results of an African-led initiative, a contextually relevant motor performance test was developed, the PERFormance and FITness test battery (PERF-FIT), that is open-source and specifically tailored for low-resource African settings. This study provides the first age- and sex-specific motor skill norms for African children aged 6–12. By generating normative data alongside its previously established robust psychometric properties, the PERF-FIT is positioned as a critical resource for clinicians, educators, and policymakers working to monitor and enhance motor performance and physical fitness among African children.
Rapid scaffold-hopping for molecular glues: from fragments to cell-active probes targeting the 14-3-3/ERα complex
Authors: Arkin Michelle , Konstantinidou Markella , Zingiridis Marios , Pennings Marloes , Fragkiadakis Michael , Virta Johanna , Revalde Jezrael , Visser Emira , Ottmann Christian , Brunsveld Luc , Neochoritis Constantinos
Published: February 2025

Molecular glues, small molecules that bind cooperatively at a protein-protein interface, have emerged as powerful modalities for the modulation of protein-protein interactions (PPIs) and “undruggable” targets. The systematic identification of new chemical matter with a molecular glue mechanism of action remains a significant challenge in drug discovery. Here, we present a scaffold hopping approach, using as a starting point our previously developed molecular glues for the native 14-3-3/estrogen receptor alpha (ERα) complex. The novel, computationally designed scaffold was based on the Groebke-Blackburn-Bienaymé multi-component reaction (MCR), leading to drug-like analogs with multiple points of variation, thus enabling the rapid derivatization and optimization of the scaffold. Structure-activity relationships (SAR) were developed using intact mass spectrometry and TR-FRET. Rational structure-guided optimization was facilitated by crystal structures of ternary complexes with the glues, 14-3-3 and phospho-peptides mimicking the highly disordered C-terminus of ERα. We measured the kinetics of 14-3-3/ERαpeptide binding by SPR, using a format in which a 14-3-3/molecular glue complex was immobilized on the SPR chip. The most potent compounds stabilized the complex by 100-fold and increased the residence time by 14-fold. Cellular stabilization of 14-3-3/ERα for the most potent analogs was confirmed using a NanoBRET assay with full-length proteins in live cells (EC50 = 2.7 – 5 µM). Our approach highlights the potential of MCR chemistry, combined with scaffold hopping, to drive the development and optimization of unprecedented molecular glue scaffolds.
Education, Occupation and Income Inequalities in Obesity Among Portuguese Women and Men: Evidence from National Health Surveys (2005–2019)
Authors: Valente Berta , Severo Milton , Gerdtham Ulf-Göran , Fraga Sílvia , Araújo Joana
Published: February 2025

Introduction: We aimed to examine socioeconomic inequalities in obesity among Portuguese women and men from 2005–2019 with data from National Health Surveys (NHSs).
Methods: We analysed weighted data corresponding to 20–64-year-old adults from the 2005/2006 (N̂= 6,508,833), 2014 (N̂=6,227,041), and 2019 (N̂=6,073,178) NHS. Socioeconomic position (SEP) included education (no formal education, 6th, 9th, and 12th grades, postsecondary education, and higher education), occupation (unemployed, operations/trade, technical/administrative, and senior professional/managerial), and monthly household net income (quintiles). Obesity was defined as body mass index (BMI) ≥ 30 kg/m² from self-reported weight and height. Slope index of inequality (SII) and relative index of inequality (RII) were used to measure absolute and relative inequalities, respectively. Log-binomial regression model was used to examine the relationship between obesity and socioeconomic indicators, employing an identity link function to calculate SII (absolute differences in predicted obesity incidence between highest and lowest SEP) and a log link function to estimate RII (ratio of obesity prevalence between these groups). Trends and overall SII and RII were analysed by socioeconomic indicators and sex, with significance set at p < 0.05.
Results: We found statistically significant socioeconomic inequalities in terms of obesity: SII consistently exhibited negative values, and RII was less than 1, indicating a concentration of obesity among adults with lower SEP. Overall, education-related SII and RII were greater for women [SII (95% CI)= -0.27(-0.29;-0.24); RII (95%CI) = 0.18(0.15;0.21)] than for men [SII= -0.16(-0.19;-0.13); RII = 0.35(0.29,0.44)]. Similarly, occupational and income-related SIIs and RIIs were greater among women, although they were smaller in magnitude than education was, and SIIs and RIIs were minimal in men. From 2005–2019, sex differences in absolute education-, occupation-, and income-related inequalities remained relatively stable, with slight variations in the SII values (education: -0.11 to -0.10; occupation: constant at 0.11; income: -0.09 to -0.08). Similarly, over the study period, sex differences in relative education-related inequalities remained stable (RII: constant at 0.16), while occupational-related inequalities decreased (RII:0.42 to 0.31), and income-related inequalities showed minimal changes (RII:0.32 to 0.31).
Conclusion: Socioeconomic inequalities in obesity persist and disproportionately affect women. The gender gap in socioeconomic inequalities in obesity has remained largely unchanged.
Uso de poesias e músicas como estímulo do consumo alimentar e promoção da qualidade de vida em idosos institucionalizados
Authors: EUGÊNIO Lauralice Carvalho , PEREIRA Rafaela Corrêa , ANGELIS-PEREIRA Michel Cardoso de
Published: February 2025

Este trabalho teve como objetivo relatar a experiência de desenvolvimento de ações extensionistas com idosos residentes em uma instituição de longa permanência (ILP). Essas ações envolveram a obtenção de relatos autobiográficos para composição de poesias e seleção de músicas, que foram apresentadas momentos antes do jantar. O consumo alimentar foi avaliado antes e depois das apresentações, para avaliar os efeitos do engajamento em atividades de valor afetivo. As ações se mostraram capazes de aumentar em até 38,6% o consumo alimentar no jantar e exerceu influência positiva sobre o bem-estar dos participantes. A música e a poesia trouxeram benefícios psicológicos e emocionais pelo compartilhamento de experiências significativas ou pela sobreposição de estigmas relacionados ao envelhecimento. A construção poética com base nas histórias de vida forneceu ainda representação intrínseca da vida, oferecendo uma forma emocionalmente envolvente de comunicar dados de investigação.
Drought risk assessment and mapping under changing climate: the East Hararge zone in Ethiopia
Authors: Serur Abdulkerim Bedewi , Kebira Huseyidin Mohammed
Published: February 2025

Drought is a period of abnormally dry weather that causes hydrological imbalances, significantly impacting agricultural production in Ethiopia. This study aims to assess and map drought-risk areas in the East Hararge zone using satellite data and global climate models. We analyzed the spatial and temporal characteristics of historical droughts through remotely sensed Climate Hazard Group Infrared Precipitation with Station (CHIRPS) rainfall and Moderate Resolution Imaging Spectroradiometer (MODIS) vegetation data, utilizing the CanESM5 dataset from CMIP6 to identify drought risk under changing climate conditions. Drought indices, such as the Standardized Precipitation Index (SPI), adjusted SPI (aSPI), Normalized Difference Vegetation Index (NDVI), and NDVI anomaly were employed, with validation against crop yield anomalies showing correlation coefficients of r = 0.72, 0.74, and 0.78 for SPI, NDVI, and NDVI anomaly, respectively. The analysis revealed that 29.8 and 26.7% of the area experienced moderate and slight drought over the past 12 years, respectively. Trend analysis indicated a significant increase in drought occurrences with a rate of −0.003 (p = 0.046) based on SPI_6, while aSPI analysis showed a general decrease in drought risk areas at a rate of 0.466. Frequency analysis projected drought occurrence every 2 years under the SSP2 4.5 scenario. This study provides essential baseline information and future predictions to monitor real-time drought situations and inform adaptation strategies in East Hararge, Ethiopia.
Analyzing the impact of different forms of precipitation (rain and snow) on drought
Authors: Liu Hongying , Wang Jiang
Published: February 2025

Precipitation is a key driving factor of drought. This study advanced the first investigation of the impact of different forms of precipitation on drought. This study used the gridded dataset of different forms of precipitation (snow, sleet, and rain) and terrestrial hydrological dataset, with the study period from 1961 to 2015. The standardized precipitation index (SPI) and the standardized runoff index (SRI) were employed to monitor meteorological drought and hydrological drought, respectively. The SPI calculated based on rainfall, precipitation, and snowfall was defined as SPIp, SPIr, and SPIn, respectively. Run theory was used to identify drought events. The drought propagation time and degree was estimated based on the maximum Pearson correlation coefficient method. The results showed that (1) the annual snowfall amounts were higher in the Qinghai–Tibetan Plateau (QTP) and the temperate humid and sub-humid northeast China (THSN). The Southeast Basin and the Pearl River Basin showed a higher runoff amount and an increasing trend. (2) The meteorological drought events of rainfall presented obviously higher severity and duration than the precipitation in northern China and QTP. The hydrological drought event exhibited relatively high severity and duration in THSN and QTP. (3) The propagation degree and time of SPIr–SRI was higher than that of SPIp–SRI in northeastern China and QTP.
Making the Genocide Convention Globally Effective by the Doctrine of Prevention. Comments on the ICJ Provisional Measures Orders in the case of South Africa v. Israel
Authors: Lachowski Tomasz
Published: February 2025

On 29 December 2023, South Africa filed an application against Israel before the International Court of Justice (ICJ) concerning alleged violations of its obligations under the UN Convention on the Prevention and Punishment of the Crime of Genocide of 1948 in relation to the protected group of Palestinians in the course of the large-scale military operation in Gaza Strip launched by the Israeli authorities as a response to an attack carried out by Hamas on Israel on 7 October 2023. The main aim of this case commentary is to analyze the provisional measure orders issued by the ICJ in the Genocide Convention case (South Africa v. Israel) on 26 January 2024, 28 March 2024 and 24 May 2024 in the light of South Africa’s effort to make the Genocide Convention ‘globally effective’ by emphasizing the key role played by the obligation to prevent genocide in a process of securing the most fundamental rights of the protected groups under this treaty. Besides, it examines the interrelated issue of the ability of the ICJ to address the hard legal cases with strong political implications by the instrument of provisional measures.
Imagens e sinais: uma proposta de ensino de história através da Língua Brasileira de Sinais
Authors:   , Almeida Márcio Araújo de
Published: February 2025

O presente estudo tem como objetivo compreender o uso didático dos elementos visuais e da Língua
Brasileira de Sinais (LIBRAS), pelos profissionais da Educação Inclusiva e professores de História
para o ensino da disciplina História aos alunos surdos das escolas públicas de Ensino Médio, na
região do Território de Identidade do Piemonte Norte de Itapicuru - TIPNI, no estado da Bahia. Para a
análise dos dados, a pesquisa baseou-se na metodologia qualitativa, segundo os conceitos de
Minayo (2007), Macedo (2000), Soares e Fazenda (1992) e Pereira (1983), e para tal foram utilizadas
as narrativas colhidas durante 15 entrevistas semiestruturadas feitas em formato remoto com
profissionais envolvidos no Ensino de História no Ensino Médio na rede pública da região. Primeiro, é
feita uma exposição de fatos históricos e movimentos político-sociais relativos à Comunidade Surda
mundial e brasileira afim de se entender como a região pesquisada foi influenciada por esses
movimentos. Em segundo são apresentados os prejuízos para o Ensino de História das aquisições
tardias da Primeira Língua (Libras) e da Segunda Língua (Português) pelos alunos surdos, bem como
da importância da participação familiar no aprendizado de ambas as línguas. E por último, a partir dos
relatos foi possível inferir a necessidade de formação continuada para os docentes em História, como
também o indispensável trabalho colaborativo das equipes multiprofissionais inclusivas neste
processo de ensino-aprendizagem. Essa proposta é segundo a teoria enunciativa de Bakhtin, refletir
sobre o contexto e as línguas na construção de propostas educacionais para alunos surdos. Dessa
forma, concluiu-se que as imagens sinalizadas (fotografias, gestos, códigos somados às sinalizações
em Libras) são imprescindíveis para o desenvolvimento da pessoa surda, devendo ser usadas em
parceria com equipe multiprofissional e o docente de História com vista na otimização do processo de
ensino-aprendizagem de surdos
A Review on Melanoma Brain Metastases
Authors: Shrestha Sabi , Cook Charles M. , Parekh Jay , mattei jane
Published: February 2025

Melanoma brain metastases (MBM) are associated with poor prognosis and remain a significant
challenge in oncology. In recent years, significant progress has been made in understanding the molecular
mechanisms underlying MBM. Advances in targeted therapies, immunotherapies, and stereotactic radiosurgery
(SRS) have significantly improved patient survival. This study presents an overview of the current
landscape of treatment approaches and emerging modalities for MBM treatment, highlighting recent advancements
and future directions for research and clinical practice.
Regulatory Effect of Non-Coding RNAs on Programmed Cell Death in Melanoma: Novel Therapeutic Crosstalk for Targeted Therapy
Authors: Fazlollahpour-naghibi Andarz , Taha Seyed Reza , Shariatzadeh Mahdieh , Daneshdoust Danyal , Bagheri Kimia , Farkhondeh Tahereh , Samini Mohammad , Pourhanifeh Mohammad Hossein , Samarghandian Saeed
Published: February 2025

Cutaneous melanoma, one of the most fatal and aggressive types of skin cancer, is a malignant tumor created from pigment-producing cells called melanocytes. The mor-bidity and incidence rate of melanoma are increasing around the world. Considering all developments in diagnostic and therapeutic approaches, early diagnosis and more effective targeted therapies are still urgent for melanoma. Non-coding RNAs (ncRNAs), including microRNAs and long non-coding RNAs, are key role players in fundamental cellular pro-cesses and have various biological properties. It has been demonstrated that the dysregula-tion of these biomarkers contributes to melanoma pathogenesis. Furthermore, programmed cell death (PCD), as an important cellular event, has been shown to play a role in the initi-ation and progression of cutaneous melanoma. Recent investigations have reported that the interplay between ncRNAs and PCD can be considered a novel choice for targeted therapy in melanoma. Thus, this review discusses PCD-related ncRNAs in melanoma, focusing on underlying pathways.
Evaluating the influence of St. John’s Wort on Naproxen Pharmacokinetics and Pharmacodynamics: A Drug Interaction Assessment
Authors: Halumane Keerthana S. , Kadiri Sunil Kumar
Published: February 2025

Introduction:

Rheumatoid arthritis (RA) is a chronic autoimmune disease which leads to pain and disability that may trigger anxiety and sleep disturbances. Naproxen and St.John’s Wort concomitant administration in RA and anxiety raises the question of safety due to a potential drug interaction.

Materials and Methods:

Albino Wistar rats were treated with naproxen and St. John’s Wort for 30 days. The study involved the evaluation of safety of naproxen when combined with St. John’s Wort by estimation of biochemical markers such as SGOT, SGPT, TG’s, Creatinine, BUN, the extent of gastromucosal damage and estimation of AUC, t1/2 and Clearance using blood serum analysis with HPLC after 30 days of treatment. Histopatho-logical studies were also conducted to determine the tissue architecture.

Results:

Elevated levels of hepatic markers SGOT, SGPT, TG, and gastro-mucosal dam-age with enhanced ulcer index were found in naproxen-St. John’s Wort treated rats as compared to only naproxen treated rats. HPLC analysis displayed increased AUC and t1/2 of naproxen with decreased clearance in naproxen-St. John’s Wort treated rats. Histo-pathological findings revealed tissue rupture and mucosal damage supporting the naproxen toxicity.

Conclusion:

Consulting a healthcare professional before combining St. John's Wort with naproxen is essential to assess potential risks, manage drug interactions, and ensure safety. Personalized advice helps optimize treatment outcomes for both rheumatoid arthritis and mental health.

other:

Keywords: Naproxen, St. John’s Wort, biochemical, gastromucosal, drug interactions, NSAID, rheumatoid arthritis.
Corrigendum to: Nanotheranostics: The Fabrication of Theranostics with Nanoparticles and their Application to Treat the Neurological Disorders
Authors: Singh Astha , Patel Aakriti , Chaudhary Hema , Yadav Kiran , Minocha Neha
Published: February 2025

The error was noted after the publication of the article titled ‘Nanotheranostics: The Fabrication of Theranostics with
Nanoparticles and their Application to Treat the Neurological Disorders’’, published in Recent Patents on Nanotechnology,
2025, 1, 17-34 [1], that a part of the text was inadvertently omitted. The missing text has now been included as:

The original article can be found online at: https://www.eurekaselect.com/article/132973

We regret the error and apologize to readers.

Details of the error and a correction are provided here.

Original:

Nanotheranostic
However, we may encounter more significant difficulties with their in vivo studies by invalidating their safety and efficacy
before clinical applications.

Corrected:

Nanotheranostic systems are being utilised in addition to imaging and treatment to track pharmacokinetics, the dispersion of
particles in the tissue, and drug accumulation at the target site. Using this cutting-edge technology, a thorough understanding of
the pathophysiology of neurological illnesses has been attained. The manufacture and physiochemical characterisation of
nanotheranostics has been the main foci of notable in vitro studies in the current situation.

However, we may encounter more significant difficulties with their in vivo studies by invalidating their safety and efficacy
before clinical applications.
Sociability dan Place Attachment Sebagai Faktor Livability Ruang Publik (Kasus: Kawasan Permukiman Pecinan Pasar Lama Tangerang)
Authors:   Magister Arsitektur, Fakultas Teknik Sipil dan Perancangan, Universitas Trisakti, Jakarta, Lailika Alfiani Nur , Hartanti Nurhikmah Budi
Published: February 2025

Providing access to safe and inclusive public spaces is the target of the UN's Sustainable Development Goals (SDGs). There are challenges to achieving this goal because of the high density in many areas in Indonesia, which occurs in the Pasar Lama area of Tangerang, causing limited public open space. Nevertheless, residents of the Pasar Lama area still actively use the available spaces between buildings, which may have different standards from the literature, as places for social activities. Thus, this study aims to investigate the factors contributing to the livability of public spaces in the Pasar Lama area. This study uses a qualitative method with purposive random sampling, selecting 20 informants from 7 identified public spaces to be interviewed. Primary data includes interviews, observations, mapping, and secondary data from various literature on standards of livable public spaces. The results of this study conclude that sociability and place attachment factors play an important role in making these spaces livable. The high level of social interaction and the existence of supporting facilities at every point in the public space reflect a high level of sociability and encourage public space to continue to be used actively. The strong place attachment felt by residents also creates a sense of responsibility towards the environment where they live.
Implementasi Sustainable Streetscape pada Koridor Jalan Jenderal Basuki Rahmat, Kota Malang Berdasarkan Persepsi Masyarakat
Authors:   Magister Arsitektur Lingkungan Binaan, Fakultas Teknik, Universitas Brawijaya, Fanda Aigan Mubiena , Ernawati Jenny ,   Departemen Arsitektur, Universitas Brawijaya, Malang, Santoso Joko Triwinarto ,   Departemen Arsitektur, Universitas Brawijaya, Malang
Published: February 2025

However, not all cities have uniformly implemented sustainable streetscape, particularly in the context of historic corridors, despite its critical role in enhancing urban success and boosting tourist appeal. The goal of this study is to look at how to create sustainable streetscapes using urban and social principles and public opinion. The Jalan Jenderal Basuki Rahmat corridor after the changes was used as an example. This research utilizes a descriptive quantitative method to identify the actual conditions through direct observations and public impressions, using questionnaires with a Likert scale, which are then analyzed through mean score analysis. The characteristics of this study include legibility, comfort, safety, beauty, liveliness, and healthy urban communities. The study's results show that, in the public's opinion, the implementation of a sustainable streetscape along the Jalan Jenderal Basuki Rahmat corridor meets urban and social principles. The variables of attractiveness and liveliness got the highest mean scores. The Malang City Government anticipates this research to play a significant role in facilitating the city's success.
Branding Through Interior Design: Exploring Theory, and Interpretation
Authors:   Interıor Design, Institut Teknologi Sepuluh Nopember, Surabaya, Ramadhina R Mekar Liza , Astuti Susy Budi ,   Interıor Design, Institut Teknologi Sepuluh Nopember, Surabaya
Published: February 2025

The theory of interior branding is a concept proposed by Kim Kuhteubl (2016) in her book "Branding + Interior Design: Visibility and Business Strategy for Interior Designers". The theory of interior branding explores the role of interior design in reinforcing brand identity and customer loyalty. Discussion regarding this theory can be found in journals/articles that examine the implementation of interior branding in various commercial spaces. Among these discussions are explanations concerning the aspects that contribute to interior branding, such as vision, story, and energy. However, in-depth explanations regarding the meaning of these aspects in forming interior branding are still limited. This limitation poses a risk of generating multiple interpretations of the theory of interior branding. Nevertheless, these aspects can be further elucidated by referencing fundamental theories of interior design. This journal aims to complement the explanations of each aspect that shapes interior branding. A more comprehensive explanation can provide a deeper understanding. The research method employed is a literature review method related to each relevant keyword. The literature review sources are limited to the fields of interior design and architecture to ensure relevance and alignment with the context of the research.
Determining Child-Friendly Villages as Thematic Tourism Villages (Case Study: Lamongan Regency)
Authors:   Jurusan Arsitektur, Universitas Islam Darul ‘Ulum, Lamongan, Yusuf Mimin Aminah , Qahar Dhiah Agustina ,   Jurusan Arsitektur, Universitas Islam Darul ‘Ulum, Lamongan, Setiadi Amos ,   Jurusan Arsitektur, Universitas Atma Jaya Yogyakarta, Heriyanto Muhil Frido ,   Jurusan Arsitektur, Universitas Islam Darul ‘Ulum, Lamongan
Published: February 2025

The Child-Friendly Village Program (DRA) in Lamongan Regency is a continuation of both the Child-Friendly Regency program and the Habitat Agenda II, specifically the Child-Friendly City initiative. Although Lamongan Regency lacks a designated DRA village, several villages have demonstrated commitment and progress in meeting the DRA indicators. In line with the priority program, namely tourist villages, DRA needs to be studied as a thematic tourism village because it has specific tourist attractions and attractions for children. This research aims to determine potential villages for thematic tourism based on Child-Friendly Villages. This study uses a case study method. We collected data through in-depth interviews and observation techniques. The data analysis employs a weighting technique (scoring) to evaluate tourism potential and DRA implementation. This technique involves assigning a score of 86-100 for very good, 71-85 for good, 56-70 for quite good, and less than 55 for not good. The results of the study show that the potential village with the highest value is Kendal Sekaran Village. This research provides practical recommendations for local governments in the development of child-friendly thematic tourism villages, as well as being a reference for other villages in meeting the Child-Friendly Village indicators.
Tracing Tangible Aspect Around Dr Radjiman Street Corridor in Surakarta (From the Perspective of Architecture Students)
Authors:   Program Studi Arsitektur, Fakultas Arsitektur dan Desain, Institut Teknologi Nasional, Bandung, Subekti Bambang , Hidayat Robi ,   Program Studi Arsitektur, Fakultas Arsitektur dan Desain, Institut Teknologi Nasional, Bandung, Wardhani Mustika Kusumaning ,   Program Studi Arsitektur, Fakultas Arsitektur dan Desain, Institut Teknologi Nasional, Bandung
Published: February 2025

Street corridors in a historical area are vital in forming an element of the city's image. Dr Radjiman's corridor in Surakarta is part of a historical area containing residents' daily activities. Physically, humans can visually perceive colour, ornament and material elements as a building's facade on two sides of the corridor. This study aims to trace the visual elements in the corridor, which can be seen from the physical aspect. The method used in the research is mixed-methods based, and the respondent data sample obtained is probability sampling. This research can provide a physical description of what is found around the corridor. This research found that visually, the colour, material and ornamental aspects create a diverse mix and match the dominance of white, fabricated materials and cultural acculturation ornaments such as Dutch, Chinese Peranakan and Javanese heritage ornaments. The results of this research can become scientific findings to support efforts to revitalize street corridors in Surakarta.
Development of a Life Cycle Sustainability Assessment Framework for Hemp-Based Building Materials in Australia
Authors: Aybar Daniela Milagros Rivas , Biswas Wahidul , John Michele
Published: February 2025

The construction industry, a cornerstone of global economic and social progress, is under increasing pressure to adopt sustainable practices due to its significant environmental footprint. Industrial hemp (Cannabis sativa L.) has gained attention as a renewable material for building applications, offering potential reductions in greenhouse gas emissions and resource consumption. However, its broader sustainability performance remains underexplored. This study develops a comprehensive Life Cycle Sustainability Assessment (LCSA) framework to evaluate the environmental, economic, and social implications of hemp-based building materials in Australia. The framework integrates environmental life cycle assessment, life cycle costing, and social life cycle assessment based on ISO 14040-44 standards. Using a participatory approach, 19 indicators were identified relevant for the sustainability assessment of hemp-based materials through consultation with 30 stakeholders across the construction, hemp industries, and academia. By addressing critical gaps in methodology, this study provides a robust tool for stakeholders to optimise the sustainability performance of hemp-based building materials and advance net-zero construction practices.