bluuebunny/crossref_metadata_2025 huggingface dataset:
The Effects of Pregestational Overweight and Obesity on Maternal Lipidome in Pregnancy: Implications for Newborns’ Characteristics
Authors: Derikonjic Minja , Saric Matutinovic Marija , Vladimirov Sopic Sandra , Antonic Tamara , Stefanovic Aleksandra , Vekic Jelena , Ardalic Daniela , Miljkovic-Trailovic Milica , Stankovic Marko , Gojkovic Tamara , Ivanisevic Jasmina , Munjas Jelena , Jovicic Snezana , Mikovic Zeljko , Zeljkovic Aleksandra
Published: July 2024

Obesity is an important risk factor for the development of pregnancy complications. We investigated the effects of pregestational overweight and obesity on maternal lipidome during pregnancy and on newborns’ characteristics. The study encompassed 131 pregnant women, 99 with pre-pregnancy body mass index (BMI) < 25 kg/m2 and 32 with BMI ≥ 25 kg/m2. Maternal lipid status parameters, plasma markers of cholesterol synthesis and absorption and sphingolipids were determined in each trimester. Data on neonatal height, weight and APGAR scores were assessed. The results showed a higher prevalence (p < 0.05) of pregnancy and childbirth complications among the participants with elevated pregestational BMI. Levels of total cholesterol, HDL-cholesterol (p < 0.05) and LDL-cholesterol (p < 0.01) were significantly lower, and concentrations of triglycerides were higher (p < 0.05) in women with increased pre-gestational BMI. Lower concentrations of the cholesterol synthesis marker, desmosterol, in the 2nd trimester (p < 0.01) and the cholesterol absorption marker, campesterol, in each trimester (p < 0.01, p < 0.05, p < 0.01, respectively) were also found in this group. Markers of maternal cholesterol synthesis were in positive correlation with neonatal APGAR scores in the group of mothers with healthy pre-pregnancy weight but in negative correlation in the overweight/obese group. Our results indicate that gestational adaptations of maternal lipidome depend on her pregestational nutritional status and that such changes may affect neonatal outcomes.
Fetal Cannabinoid Syndrome: Behavioral and Brain Alterations of the Offspring Exposed to Dronabinol during Gestation and Lactation
Authors: Navarro Daniela , Gasparyan Ani , Navarrete Francisco , Manzanares Jorge
Published: July 2024

This study establishes a fetal cannabinoid syndrome model to evaluate the effects of high doses of dronabinol (synthetic THC) during pregnancy and lactation on behavioral and brain changes in male and female progeny and their susceptibility to alcohol consumption. Female C57BL/6J mice received dronabinol (10 mg/kg/12 h, p.o.) from gestational day 5 to postnatal day 21. On the weaning day, the offspring were separated by sex, and on postnatal day 60, behavioral and neurobiological changes were analyzed. Mice exposed to dronabinol exhibited increased anxiogenic and depressive-like behaviors and cognitive impairment. These behaviors were associated with neurodevelopment-related gene and protein expression changes, establishing, for the first time, an association among behavioral changes, cognitive impairment, and neurobiological alterations. Exposure to dronabinol during pregnancy and lactation disrupted the reward system, leading to increased motivation to consume alcohol in the offspring. All these modifications exhibited sex-dependent patterns. These findings reveal the pronounced adverse effects on fetal neurodevelopment resulting from cannabis use during pregnancy and lactation and strongly suggest the need to prevent mothers who use cannabis in this period from the severe and permanent side effects on behavior and brain development that may occur in their children.
Blockage of Autophagy for Cancer Therapy: A Comprehensive Review
Authors: Hassan Ahmed Mostafa Ibrahim Abdelrahman , Zhao Yuxin , Chen Xiuping , He Chengwei
Published: July 2024

The incidence and mortality of cancer are increasing, making it a leading cause of death worldwide. Conventional treatments such as surgery, radiotherapy, and chemotherapy face significant limitations due to therapeutic resistance. Autophagy, a cellular self-degradation mechanism, plays a crucial role in cancer development, drug resistance, and treatment. This review investigates the potential of autophagy inhibition as a therapeutic strategy for cancer. A systematic search was conducted on Embase, PubMed, and Google Scholar databases from 1967 to 2024 to identify studies on autophagy inhibitors and their mechanisms in cancer therapy. The review includes original articles utilizing in vitro and in vivo experimental methods, literature reviews, and clinical trials. Key terms used were “Autophagy”, “Inhibitors”, “Molecular mechanism”, “Cancer therapy”, and “Clinical trials”. Autophagy inhibitors such as chloroquine (CQ) and hydroxychloroquine (HCQ) have shown promise in preclinical studies by inhibiting lysosomal acidification and preventing autophagosome degradation. Other inhibitors like wortmannin and SAR405 target specific components of the autophagy pathway. Combining these inhibitors with chemotherapy has demonstrated enhanced efficacy, making cancer cells more susceptible to cytotoxic agents. Clinical trials involving CQ and HCQ have shown encouraging results, although further investigation is needed to optimize their use in cancer therapy. Autophagy exhibits a dual role in cancer, functioning as both a survival mechanism and a cell death pathway. Targeting autophagy presents a viable strategy for cancer therapy, particularly when integrated with existing treatments. However, the complexity of autophagy regulation and the potential side effects necessitate further research to develop precise and context-specific therapeutic approaches.
Benzoxazinoids Biosynthetic Gene Cluster Identification and Expression Analysis in Maize under Biotic and Abiotic Stresses
Authors: Zhao Xiaoqiang , Shi Zhenzhen , He Fuqiang , Niu Yining , Qi Guoxiang , Sun Siqi , Li Xin , Gao Xiquan
Published: July 2024

Benzoxazinoids (BXs) are unique bioactive metabolites with protective and allelopathic properties in maize in response to diverse stresses. The production of BXs involves the fine regulations of BXs biosynthetic gene cluster (BGC). However, little is known about whether and how the expression pattern of BGC members is impacted by biotic and abiotic stresses. Here, maize BGC was systemically investigated and 26 BGC gene members were identified on seven chromosomes, for which Bin 4.00–4.01/4.03–4.04/7.02 were the most enriched regions. All BX proteins were clearly divided into three classes and seven subclasses, and ten conserved motifs were further identified among these proteins. These proteins were localized in the subcellular compartments of chloroplast, endoplasmic reticulum, or cytoplasmic, where their catalytic activities were specifically executed. Three independent RNA-sequencing (RNA-Seq) analyses revealed that the expression profiles of the majority of BGC gene members were distinctly affected by multiple treatments, including light spectral quality, low-temperature, 24-epibrassinolide induction, and Asian corn borer infestation. Thirteen differentially expressed genes (DEGs) with high and specific expression levels were commonly detected among three RNA-Seq, as core conserved BGC members for regulating BXs biosynthesis under multiple abiotic/biotic stimulates. Moreover, the quantitative real-time PCR (qRT-PCR) verified that six core conserved genes in BGC were significantly differentially expressed in leaves of seedlings upon four treatments, which caused significant increases in 2,4-dihydroxy-7-methoxy-1,4-benzoxazin-3-one (DIMBOA) content under darkness and wound treatments, whereas a clear decrease in DIMBOA content was observed under low-temperature treatment. In conclusion, the changes in BX metabolites in maize were regulated by BGC gene members in multiple stress presences. Therefore, the identification of key genes associated with BX accumulation under biotic/abiotic stresses will provide valuable gene resources for breeding maize varieties with enhanced capability to adapt to environmental stresses.
Synergistic Targeting of Innate Receptors TLR7 and NOD2 for Therapeutic Intervention in Multiple Sclerosis
Authors: Dubik Magdalena , Marczynska-Grzelak Joanna , Sørensen Michael Zaucha , Dieu Ruthe Storgaard , Rusin Dominika , Schiöth Eydís Sigurdardóttir , Ramazani Bita , Belal Rouhin , Ojha Bhavya , Krieger Jonathan , Arengoth Dina S. , Wlodarczyk Agnieszka , Owens Trevor , Khorooshi Reza
Published: July 2024

Regulation of neuroinflammation is critical for maintaining central nervous system (CNS) homeostasis and holds therapeutic promise in autoimmune diseases such as multiple sclerosis (MS). Previous studies have highlighted the significance of selective innate signaling in triggering anti-inflammatory mechanisms, which play a protective role in an MS-like disease, experimental autoimmune encephalomyelitis (EAE). However, the individual intra-CNS administration of specific innate receptor ligands or agonists, such as for toll-like receptor 7 (TLR7) and nucleotide-binding oligomerization-domain-containing protein 2 (NOD2), failed to elicit the desired anti-inflammatory response in EAE. In this study, we investigated the potential synergistic effect of targeting both TLR7 and NOD2 simultaneously to prevent EAE progression. Our findings demonstrate that simultaneous intrathecal administration of NOD2- and TLR7-agonists led to synergistic induction of Type I IFN (IFN I) and effectively suppressed EAE in an IFN I-dependent manner. Suppression of EAE was correlated with a significant decrease in the infiltration of monocytes, granulocytes, and natural killer cells, reduced demyelination, and downregulation of IL-1β, CCL2, and IFNγ gene expression in the spinal cord. These results underscore the therapeutic promise of concurrently targeting the TLR7 and NOD2 pathways in alleviating neuroinflammation associated with MS, paving the way for novel and more efficacious treatment strategies.
Associations between Diabetes Mellitus and Selected Cancers
Authors: Pliszka Monika , Szablewski Leszek
Published: July 2024

Cancer is one of the major causes of mortality and is the second leading cause of death. Diabetes mellitus is a serious and growing problem worldwide, and its prevalence continues to grow; it is the 12th leading cause of death. An association between diabetes mellitus and cancer has been suggested for more than 100 years. Diabetes is a common disease diagnosed among patients with cancer, and evidence indicates that approximately 8–18% of patients with cancer have diabetes, with investigations suggesting an association between diabetes and some particular cancers, increasing the risk for developing cancers such as pancreatic, liver, colon, breast, stomach, and a few others. Breast and colorectal cancers have increased from 20% to 30% and there is a 97% increased risk of intrahepatic cholangiocarcinoma or endometrial cancer. On the other hand, a number of cancers and cancer therapies increase the risk of diabetes mellitus. Complications due to diabetes in patients with cancer may influence the choice of cancer therapy. Unfortunately, the mechanisms of the associations between diabetes mellitus and cancer are still unknown. The aim of this review is to summarize the association of diabetes mellitus with selected cancers and update the evidence on the underlying mechanisms of this association.
A Combined Metabolome and Transcriptome Reveals the Lignin Metabolic Pathway during the Developmental Stages of Peel Coloration in the ‘Xinyu’ Pear
Authors: Jiang Cuicui , Lyu Keliang , Zeng Shaomin , Wang Xiao’an , Chen Xiaoming
Published: July 2024

Sand pear is the main cultivated pear species in China, and brown peel is a unique feature of sand pear. The formation of brown peel is related to the activity of the cork layer, of which lignin is an important component. The formation of brown peel is intimately associated with the biosynthesis and accumulation of lignin; however, the regulatory mechanism of lignin biosynthesis in pear peel remains unclear. In this study, we used a newly bred sand pear cultivar ‘Xinyu’ as the material to investigate the biosynthesis and accumulation of lignin at nine developmental stages using metabolomic and transcriptomic methods. Our results showed that the 30 days after flowering (DAF) to 50DAF were the key periods of lignin accumulation according to data analysis from the assays of lignin measurement, scanning electron microscope (SEM) observation, metabolomics, and transcriptomics. Through weighted gene co-expression network analysis (WGCNA), positively correlated modules with lignin were identified. A total of nine difference lignin components were identified and 148 differentially expressed genes (DEGs), including 10 structural genes (PAL1, C4H, two 4CL genes, HCT, CSE, two COMT genes, and two CCR genes) and MYB, NAC, ERF, and TCP transcription factor genes were involved in lignin metabolism. An analysis of RT-qPCR confirmed that these DEGs were involved in the biosynthesis and regulation of lignin. These findings further help us understand the mechanisms of lignin biosynthesis and provide a theoretical basis for peel color control and quality improvement in pear breeding and cultivation.
Unveiling the Cutting-Edge Impact of Polarized Macrophage-Derived Extracellular Vesicles and MiRNA Signatures on TGF-β Regulation within Lung Fibroblasts
Authors: Casara Alvise , Conti Maria , Bernardinello Nicol , Tinè Mariaenrica , Baraldo Simonetta , Turato Graziella , Semenzato Umberto , Celi Alessandro , Spagnolo Paolo , Saetta Marina , Cosio Manuel G. , Neri Tommaso , Biondini Davide , Bazzan Erica
Published: July 2024

Depending on local cues, macrophages can polarize into classically activated (M1) or alternatively activated (M2) phenotypes. This study investigates the impact of polarized macrophage-derived Extracellular Vesicles (EVs) (M1 and M2) and their cargo of miRNA-19a-3p and miRNA-425-5p on TGF-β production in lung fibroblasts. EVs were isolated from supernatants of M0, M1, and M2 macrophages and quantified using nanoscale flow cytometry prior to fibroblast stimulation. The concentration of TGF-β in fibroblast supernatants was measured using ELISA assays. The expression levels of miRNA-19a-3p and miRNA-425-5p were assessed via TaqMan-qPCR. TGF-β production after stimulation with M0-derived EVs and with M1-derived EVs increased significantly compared to untreated fibroblasts. miRNA-425-5p, but not miRNA-19a-3p, was significantly upregulated in M2-derived EVs compared to M0- and M1-derived EVs. This study demonstrates that EVs derived from both M0 and M1 polarized macrophages induce the production of TGF-β in fibroblasts, with potential regulation by miRNA-425-5p.
Quantitative Proteomic Analysis of Macrophages Infected with Trypanosoma cruzi Reveals Different Responses Dependent on the SLAMF1 Receptor and the Parasite Strain
Authors: Herreros-Cabello Alfonso , del Moral-Salmoral Javier , Morato Esperanza , Marina Anabel , Barrocal Beatriz , Fresno Manuel , Gironès Núria
Published: July 2024

Chagas disease is caused by the intracellular protozoan parasite Trypanosoma cruzi. This disease affects mainly rural areas in Central and South America, where the insect vector is endemic. However, this disease has become a world health problem since migration has spread it to other continents. It is a complex disease with many reservoirs and vectors and high genetic variability. One of the host proteins involved in the pathogenesis is SLAMF1. This immune receptor acts during the infection of macrophages controlling parasite replication and thus affecting survival in mice but in a parasite strain-dependent manner. Therefore, we studied the role of SLAMF1 by quantitative proteomics in a macrophage in vitro infection and the different responses between Y and VFRA strains of Trypanosoma cruzi. We detected different significant up- or downregulated proteins involved in immune regulation processes, which are SLAMF1 and/or strain-dependent. Furthermore, independently of SLAMF1, this parasite induces different responses in macrophages to counteract the infection and kill the parasite, such as type I and II IFN responses, NLRP3 inflammasome activation, IL-18 production, TLR7 and TLR9 activation specifically with the Y strain, and IL-11 signaling specifically with the VFRA strain. These results have opened new research fields to elucidate the concrete role of SLAMF1 and discover new potential therapeutic approaches for Chagas disease.
Advancements in Radiogenomics for Clear Cell Renal Cell Carcinoma: Understanding the Impact of BAP1 Mutation
Authors: Greco Federico , D’Andrea Valerio , Buoso Andrea , Cea Laura , Bernetti Caterina , Beomonte Zobel Bruno , Mallio Carlo Augusto
Published: July 2024

Recent advancements in understanding clear cell renal cell carcinoma (ccRCC) have underscored the critical role of the BAP1 gene in its pathogenesis and prognosis. While the von Hippel–Lindau (VHL) mutation has been extensively studied, emerging evidence suggests that mutations in BAP1 and other genes significantly impact patient outcomes. Radiogenomics with and without texture analysis based on CT imaging holds promise in predicting BAP1 mutation status and overall survival outcomes. However, prospective studies with larger cohorts and standardized imaging protocols are needed to validate these findings and translate them into clinical practice effectively, paving the way for personalized treatment strategies in ccRCC. This review aims to summarize the current knowledge on the role of BAP1 mutation in ccRCC pathogenesis and prognosis, as well as the potential of radiogenomics in predicting mutation status and clinical outcomes.
Predictors of Headaches and Quality of Life in Women with Ophthalmologically Resolved Idiopathic Intracranial Hypertension
Authors: Horev Anat , Aharoni-Bar Sapir , Katson Mark , Tsumi Erez , Regev Tamir , Zlotnik Yair , Biederko Ron , Ifergane Gal , Shelef Ilan , Eliav Tal , Ben-Arie Gal , Honig Asaf
Published: July 2024

Background/objectives: The aim of this study was to evaluate the long-term outcomes of a cohort of ophthalmologically resolved female idiopathic intracranial hypertension (IIH) patients. Methods: Our cross-sectional study included adult females with at least 6 months of ophthalmologically resolved IIH. Patients with papilledema or who underwent IIH-targeted surgical intervention were excluded. Participants completed a questionnaire consisting of medical information, the Migraine Disability Assessment Scale (MIDAS) and the Headache Impact Test (HIT-6). Electronic medical records and the results of imaging upon diagnosis were retrospectively reviewed. Results: One-hundred-and-four participants (mean age 35.5 ± 11.9 years) were included (7.85 ± 7 years post-IIH diagnosis). Patients with moderate–severe disability according to the MIDAS scale (n = 68, 65.4%) were younger (32.4 ± 8.9 vs. 41.5 ± 14.4 year-old, p < 0.001), had a shorter time interval from IIH diagnosis (5.9 ± 5.3 vs. 11.7 ± 8.5 years, p < 0.001), and had lower FARB scores (indicating a more narrowed transverse-sigmoid junction; 1.28 ± 1.82 vs. 2.47 ± 2.3, p = 0.02) in comparison to patients with low–mild disability scores. In multivariate analysis, a lower FARB score (OR 1.28, 95% CI 0.89–1.75, p = 0.12) and younger age (OR 1.09, 95% CI 0.98–1.19, p = 0.13) showed a trend toward an association with a moderate–severe MIDAS score. Moreover, in the sub-analysis of patients with a moderate–severe MIDAS scale score, the 10 patients with the highest MIDAS scores had a low FARB score (1.6 ± 1.1 vs. 2.7 ± 2.4, p = 0.041). Conclusions: High numbers of patients with ophthalmologically resolved IIH continue to suffer from related symptoms. Symptoms may be associated with the length of time from the diagnosis of IIH and a lower FARB score.
The Effect of Revascularization on Lower Limb Circulation Parameters in Symptomatic Peripheral Arterial Disease
Authors: Gerken Andreas L. H. , Sigl Martin , Israel Elisa , Weiß Christel , Reißfelder Christoph , Schwenke Kay
Published: July 2024

Background: The prevalence of peripheral arterial disease and the number of revascularization procedures performed in symptomatic patients are steadily increasing. However, uncertainties remain regarding hemodynamic monitoring after revascularization and the prediction of clinical outcomes. This study aimed to investigate hemodynamic parameters with a focus on the microvasculature. Methods: This prospective, single-center study included 29 patients (15 with intermittent claudication [IC] and 14 with chronic limb-threatening ischemia [CLTI]). Before and after the revascularization procedure, in addition to the ankle–brachial index (ABI), microperfusion parameters, including microvascular blood flow, capillary oxygen saturation (SO2), and relative hemoglobin content (rHb), were assessed with lightguide spectrophotometry combined with laser Doppler flowmetry using an oxygen-to-see (O2C) device in the horizontal and elevated leg positions. Results: At baseline, SO2 in the elevated leg position was significantly lower in patients with CLTI than in those with IC (p = 0.0189), whereas the other microcirculatory parameters and ABI values were not significantly different. Patients with diabetes mellitus had a higher flow rate than those without in the horizontal leg position (p = 0.0162) but not in the elevated leg position. After successful revascularization, the flow increased immediately and significantly in both positions, whereas SO2, rHb, and the ABI did not. Conclusions: Elevated leg SO2 was significantly lower in CLTI than in clinically compensated peripheral arterial disease, whereas microvascular flow was a suitable surrogate parameter indicating successful revascularization. In studies using surgical or interventional revascularization procedures, noninvasive hemodynamic monitoring of the microcirculation at the foot level might be beneficial.
Disturbance-Observer-Based Adaptive Prescribed Performance Formation Tracking Control for Multiple Underactuated Surface Vehicles
Authors: Li Jin , Fu Mingyu , Xu Yujie
Published: July 2024

This study proposes a new disturbance-observer-based adaptive distributed formation control scheme for multiple underactuated surface vehicles (USVs) subject to unknown synthesized disturbances under prescribed performance constraints. A modified sliding mode differentiator (MSMD) is applied as a nonlinear disturbance observer to estimate unknown synthesized disturbances, which contain unknown environmental disturbances and system modelling uncertainties, thus enhancing the robustness of the system. Based on this, we impose the time-varying performance constraints on the position tracking error between the neighboring USVs. A novel differentiable error transformation equation is embedded in the prescribed performance control, and an adaptive prescribed performance controller is constructed by employing the backstepping method to ensure that the position tracking error remains within the prescribed transient and steady performance, and each USV realizes collision-free formation motion. Furthermore, a novel second-order nonlinear differentiator is introduced to extract the derivative information of the virtual control law. Finally, the numerical simulation results verify the effectiveness of the proposed control scheme.
Mitigation of Vibrio-Induced Metabolic Perturbations in Argopecten purpuratus Scallop Larvae via Probiotic Pretreatment
Authors: Muñoz-Cerro Katherine , Venter Leonie , Young Tim , Alfaro Andrea C. , Brokordt Katherina , Schmitt Paulina
Published: July 2024

Background: The decrease in the production of Argopecten purpuratus scallops in Chile is linked to extensive larval deaths in hatcheries caused by bacterial pathogens, particularly Vibrio genus, threatening sustainability. Traditional antibiotic practices raise concerns, urging research on eco-friendly strategies like bacterial probiotics. This study explores the metabolic responses of scallop larvae to Vibrio bivalvicida and evaluates the impact of the Psychrobacter sp. R10_7 probiotic on larval metabolism pre- and post-infection. Materials and Methods: Analysis detected 183 metabolite features, revealing significant changes in larval metabolites during Vibrio infection. Larvae pretreated with probiotics showed a metabolic profile comparable to non-infected larvae, indicating low impact on larval metabolome, likely due to probiotics antagonistic effect on pathogens. Results: Arachidonic acid, eicosatrienoic acid, docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), and docosapentaenoic acid (DPA) were significantly higher in non-pretreated/infected larvae compared to both pretreated/infected and non-pretreated/non-infected larvae, potentially supporting the activation of immune response in non-pretreated larvae to Vibrio infection. Identification of 76 metabolites provided insights into scallop larvae metabolome, highlighting the enriched metabolic pathways associated with energy provision and immune response. Conclusions: Probiotic pretreatment may mitigate metabolic disruptions in scallop larvae caused by Vibrio infection, suggesting a promising strategy for sustainable scallop production.
Impact of Anthropogenic Activities on Sedimentary Records in the Lingdingyang Estuary of the Pearl River Delta, China
Authors: Liu Dezheng , Lin Yitong , Zhang Tao , Huang Enmao , Zhu Zhiyuan , Jia Liangwen
Published: July 2024

High-intensity anthropogenic activities have greatly altered the estuarine-shelf depositional processes of sediments, and the intensity and frequency of the impacts of human interventions have far exceeded the natural development of estuarine systems. Since the reform and opening up, human activities such as dams, sand mining, channel dredging, and reclamation have already caused anomalous changes in the dynamical–sedimentary–geomorphological processes of the Lingdingyang Estuary (LE). Analyzing the impact of high-intensity anthropogenic activities on sedimentary processes and the hydrodynamic environment through sedimentary records can provide a scientific basis for predicting the evolution of the estuary and the sustainable development of the Guangdong–Hongkong–Macao Greater Bay Area. The aims of this study are to reveal the impact of varying intensity human activities across different periods on depositional pattern and conduct a preliminary investigation into the spatial differences in sedimentary characteristic attributed to human activities. Two cores (LD11 and LD13) located in the LE were selected for continuous scanning of high-resolution XRF, grain size, and 210Pbex dating tests, and scrutinized with the previous studies of the historical process of human activities in the LE. The results show the following: (1) The abrupt alterations in 210Pbex, geochemical indices, and grain size in LD13 happened in close proximity to the 95 cm layer, suggesting a shift in the sedimentary environment during 1994. (2) In the context of the continuous reduction in water and sediment flux into the LE after 1994, the large-scale and high-intensity human activities like sand mining, channel dredging, and reclamation are responsible for the sedimentation rate increase rather than decrease, the coarsening of sediment fractions, the frequent fluctuations in Zr/Rb, Zr/Al, Sr/Fe, and Sr/Al ratios, and the increase in anomalous extremes. (3) Sedimentary records found in locations varying in anthropogenic intensities differ greatly. Compared with the nearshore siltation area, the grain size composition in the channel area is noticeably coarser and exhibits a wider range of grain size variations. The 210Pbex is strongly perturbed and the vertical distribution is disturbed; the phenomenon of multiple inversions from the surface downwards is shown, making it impossible to carry out sedimentation rate and dating analysis, and the geochemical indicators have changed drastically without any obvious pattern. The evidence of the human activities can be retrieved in the sedimentary record of the estuary and provide a different angle to examine the impacts of the human activities.
High-Dose versus Low-Dose Oxytocin for Labor Augmentation: A Meta-Analysis of Randomized Controlled Trials
Authors: Moraes Francisco Cezar Aquino de , Kelly Francinny Alves , Leite Marianna Gerardo Hidalgo Santos Jorge , Dal Moro Lucca , Morbach Victória , Burbano Rommel Mario Rodríguez
Published: July 2024

Background/Objectives: Although oxytocin administration is recommended for delayed labor progress, there is no consensus over the preferred optimal dose of oxytocin. We aimed to perform a meta-analysis of pregnancy outcomes comparing high-dose versus low-dose oxytocin regimens for augmentation of delayed labor. Methods: PubMed, Embase, and Cochrane databases were systematically searched for studies comparing high-dose with low-dose oxytocin for labor augmentation from inception up to May 2023. The outcomes assessed were cesarean rate, instrumental delivery rate, postpartum hemorrhage, neonatal death, and uterine tachysystole. Subgroup analysis was performed with randomized controlled trials (RCTs) and propensity-matched studies. Statistical analysis was performed using Rstudio. Heterogeneity was assessed with I2 statistics, and a random-risk effect was used if I2 > 50%. Results: Twenty-one studies met inclusion criteria, and eighteen were RCTs. A total of 14.834 patients were included, of whom 7.921 (53.3%) received high-dose and 6.913 (46.6%) received low-dose oxytocin during labor augmentation. No statistical differences were found in cesarean delivery, neonatal mortality, postpartum hemorrhage and vaginal instrumentation rate. However, uterine tachysystole incidence was significantly higher with high-dose oxytocin (95% Cl, 1.30–1.94, p = 0.3; 0.6; I2 = 9%). Conclusions: Labor augmentation with a low-dose oxytocin regimen is effective as with a high-dose regimen, but with significantly less uterine tachysystole events, which can lead to intrauterine and neonatal complications. Our findings suggest that a low-dose regimen may be safe and effective for labor augmentation in medical practice.
Advanced Sperm Selection Techniques for Assisted Reproduction
Authors: Cariati Federica , Orsi Maria Grazia , Bagnulo Francesca , Del Mondo Daniela , Vigilante Luigi , De Rosa Martina , Sciorio Romualdo , Conforti Alessandro , Fleming Steven , Alviggi Carlo
Published: July 2024

Male infertility accounts for approximately 40% of infertility cases. There are many causes of male infertility, including environmental factors, age, lifestyle, infections, varicocele, and cancerous pathologies. Severe oligozoospermia, cryptozoospermia, and azoospermia (obstructive and non-obstructive) are identified as severe male factor infertility, once considered conditions of sterility. Today, in vitro fertilization (IVF) techniques are the only treatment strategy in cases of male factor infertility for which new methodologies have been developed in the manipulation of spermatozoa to achieve fertilization and increase success rates. This review is an update of in vitro manipulation techniques, in particular sperm selection, emphasizing clinical case-specific methodology. The success of an IVF process is related to infertility diagnosis, appropriate choice of treatment, and effective sperm preparation and selection. In fact, selecting the best spermatozoa to guarantee an optimal paternal heritage means increasing the blastulation, implantation, ongoing pregnancy and live birth rates, resulting in the greater success of IVF techniques.
Scenic Assessment Methodology for Preserving Scenic Viewsheds of Virginia, USA
Authors: Miller Patrick A. , Sim Jisoo , Powell Leighton , Crump Lynn
Published: July 2024

The non-profit organization Scenic Virginia is dedicated to identifying and showcasing the state’s scenic landscapes. Recently, the state incorporated a “scenic” element into its new Conserve Virginia land conservation strategy. Consequently, there is a need for a standardized assessment tool that both citizens and professionals can use to identify and evaluate the scenic value of publicly accessible viewsheds in Virginia. This paper outlines the rationale behind developing a scientifically robust protocol, which is based on an extensive literature review and photographs from Scenic Virginia’s annual photo contest. The protocol serves as a scenic assessment tool designed to encourage local citizen participation in identifying significant scenic resources in Virginia. Local communities will utilize this new tool to help them identify and evaluate their scenic assets. The protocol was reviewed by a panel of experts, and its implementation is currently underway.
Mapping Topsoil Behavior to Compaction at National Scale from an Analysis of Field Observations
Authors: Richer-de-Forges Anne C. , Arrouays Dominique , Chen Songchao , Libohova Zamir , Beaudette Dylan E. , Bourennane Hocine
Published: July 2024

Soil compaction is one of the most important and readily mitigated threats to soil health. Digital Soil Mapping (DSM) has emerged as an efficient method to provide broad-scale maps by combining soil information with environmental covariates. Until now, soil information input to DSM has been mainly composed of point-based quantitative measurements of soil properties and/or of soil type/horizon classes derived from laboratory analysis, point observations, or soil maps. In this study, we used field estimates of soil compaction to map soil behavior to compaction at a national scale. The results from a previous study enabled clustering of six different behaviors using the in situ field observations. Mapping potential responses to soil compaction is an effective land management tool for preventing future compaction. Random forest was used to make spatial predictions of soil behavior to compaction over cultivated soils of mainland France (about 210,000 km2). Modeling was performed at 90 m resolution. The map enabled us to spatially identify clusters of possible responses to compaction. Most clusters were consistent with known geographic distributions of some soil types and properties. This consistency was checked by comparing maps with both national and local-scale external sources of soil information. The best spatial predictors were available digital maps of soil properties (clay, silt, sand, organic carbon (SOC) content, and pH), some indicators of soil structural quality using SOC and clay content, and environmental covariates (T °C and relief-related covariates). Predicted maps were interpretable to support management recommendations to mitigate soil compactness at the soil–scape scale. Simple observational field data that are usually collected by soil surveyors, then stored and available in soil databases, provide valuable input data for digital mapping of soil behavior to compaction and assessment of inherent soil sensitivity to compaction.
Friction Investigation of Closed-Cell Aluminium Foam during Radial-Constrained Test
Authors: Kertesz Jozsef , Kovacs Tünde Anna
Published: July 2024

The energy-absorbing capacity and friction phenomena of different closed-cell aluminium foam-filled Al tube types are investigated through experimental compression tests. Concerning the kind of investigation, free, radial-constrained and friction tests occurred. The radial-constrained compression test results confirm that the process requires significantly more compression energy than without the constrain. Pushing away different pre-compressed foams inside the aluminium tube, the static and kinematic frictional resistances can be determined and the energy required to move them can be calculated. Knowing the value of the energy required for the frictional resistance, we can obtain how much of the energy surplus in radially inhibited compression is caused by the friction phenomena. The main goal present study is to reveal the magnitude of friction between the foam and the wall of the tube during the radially constrained test. The investigation used 0.4 and 0.7 g/cm3 density closed-cell aluminium foam whilst a compressive test was applied where the force–displacement data were recorded to calculate the absorbed energy due to friction. Considering the results of the test, it can be stated that 18% of the invested energy was used to overcome friction in the case of lighter foam and almost 23% with 0.7 g/cm3 foam during the radial-constrained test.
Facile Synthesis of Oxygen-Doped g-C3N4 Mesoporous Nanosheets for Significant Enhancement of Photocatalytic Hydrogen Evolution Performance
Authors: Jia Tiekun , Li Jingjing , Deng Zhao , Yu Dongsheng , Lee Joong Hee
Published: July 2024

In this work, oxygen-doped g-C3N4 mesoporous nanosheets (O-CNS) were synthesized via a facile recrystallization method with the assistance of H2O2. The crystal phase, chemical composition, morphological structure, optical property, electronic structure and electrochemical property of the prepared O-CNS samples were well investigated. The morphological observation combined with the nitrogen adsorption–desorption results demonstrated that the prepared O-CNS samples possessed nanosheet-like morphology with a porous structure. Doping O into g-C3N4 resulted in the augmentation of the specific surface area, which could provide more active sites for photocatalytic reactions. Simultaneously, the visible light absorption capacity of O-CNS samples was boosted owing to the regulation of O doping. The built energy level induced by the O doping could accelerate the migration rate of photoinduced carriers, and the porous structure was most likely to speed up the release of hydrogen during the photocatalytic hydrogen process. Resultantly, the photocatalytic hydrogen production rate of the optimized oxygen-doped g-C3N4 nanosheets reached up to 2012.9 μmol·h−1·g−1, which was 13.4 times higher than that of bulk g-C3N4. Thus, the significantly improved photocatalytic behavior was imputed to the synergistic effect of the porous structure, the increase in active sites, and the enhancement of visible light absorption and charge separation efficiency. Our research highlights that the synergistic effect caused by element doping will make a great contribution to the remarkable improvement in photocatalytic activity, providing a new inspiration for the construction of novel catalysts.
Engineered Mesoporous Silica-Based Nanoparticles: Characterization of Surface Properties
Authors: Grisolia Antonio , De Santo Marzia , Curcio Manuela , Cavallaro Palmira Alessia , Morelli Catia , Leggio Antonella , Pasqua Luigi
Published: July 2024

Mesoporous silica-based nanomaterials have emerged as multifunctional platforms with applications spanning catalysis, medicine, and nanotechnology. Since their synthesis in the early 1990s, these materials have attracted considerable interest due to their unique properties, including high surface area, tunable pore size, and customizable surface chemistry. This article explores the surface properties of a series of MSU-type mesoporous silica nanoparticles, elucidating the impact of different functionalization strategies on surface characteristics. Through an extensive characterization utilizing various techniques, such as FTIR, Z-potential, and nitrogen adsorption porosimetry, insights into the surface modifications of mesoporous silica nanoparticles are provided, contributing to a deeper understanding of their nanostructure and related interactions, and paving the way to possible unexpected actionability and potential applications.
Strength Optimisation of Hybrid Bolted/Bonded Composite Joints Based on Finite Element Analysis
Authors: Blier Raphael , Monajati Leila , Mehrabian Masoud , Boukhili Rachid
Published: July 2024

A finite element analysis (FEA) was conducted to examine the behaviour of single-lap quasi-isotropic (QI) and cross-ply (CP) hybrid bolted/bonded (HBB) configurations subjected to tensile shear loading. Several critical design factors influencing the composite joint strength, failure conditions, and load-sharing mechanisms that would optimise the joining performance were assessed. The study of the stress concentration around the holes and along the adhesive layer highlights the fact that the HBB joints benefit from significantly lower stresses compared to only bolted joints, especially for CP configurations. The simulation results confirmed the redundancy of the middle bolt in a three-bolt HBB joint. The stiffness and plastic behaviour of the adhesive were found to be important factors that define the transition of the behaviour of the joint from a bolted type, where load sharing is predominant, to a bonded joint. The load-sharing potential, known as an indicator of the joint’s performance, is improved by reducing the overlap length, using a low-stiffness, high-plasticity adhesive, and using thicker laminates in the QI layup configuration. Enhancing both the ratio of the edge distance to the hole diameter and washer size proves advantageous in reducing stresses within the adhesive layer, thereby improving the joint strength.
Investigation of Grain Boundary Effects in Sm0.2Ce0.8O2−x Thin Film Memristors
Authors: Shi Weikai , Wang Luyao , Yang Nan
Published: July 2024

Cerium-based materials (CeO2−x) are of significant interest in the development of vacancy-modulated resistive switching (RS) memory devices. However, the influence of grain boundaries on the performance of memristors is very limited. To fill this gap, this study explores the influence of grain boundaries in cerium-based thin film resistive random-access memory (RRAM) devices. Sm0.2Ce0.8O2−x (SDC20) thin films were deposited on (100)-oriented Nb-doped SrTiO3 (NSTO) and (110)-oriented NSTO substrates using pulsed laser deposition (PLD). Devices constructed with a Pt/SDC20/NSTO structure exhibited reversible and stable bipolar resistive switching (RS) behavior. The differences in conduction mechanisms between single-crystal and polycrystalline devices were confirmed, with single-crystal devices displaying a larger resistance window and higher stability. Combining the results of XPS and I–V curve fitting, it was confirmed that defects near the grain boundaries in the SDC-based memristors capture electrons, thereby affecting the overall performance of the RRAM devices.
Development of Carbon Black Coating on TPU Elastic Powder for Selective Laser Sintering
Authors: Chao Yu-Deh , Liu Shu-Cheng , Yeh Dong-Quan , Kumar Ajeet , Tsai Jung-Ting , Prajapati Mayur Jiyalal , Jeng Jeng-Ywan
Published: July 2024

Increased usage of selective laser sintering (SLS) for the production of end-use functional components has generated a requirement of developing new materials and process improvements to improve the applicability of this technique. This article discusses a novel process wherein carbon black was applied to the surface of TPU powder to reduce the laser reflectivity during the SLS process. The printing was carried out with a preheating temperature of 75 °C, laser energy density of 0.028 J/mm2, incorporating a 0.4 wt % addition of carbon black to the TPU powder, and controlling the powder layer thickness at 125 μm. The mixed powder, after printing, shows a reflectivity of 13.81%, accompanied by the highest average density of 1.09 g/cm3, hardness of 78 A, tensile strength of 7.9 MPa, and elongation at break was 364.9%. Compared to commercial TPU powder, which lacks the carbon black coating, the reflectance decreased by 1.78%, mechanical properties improved by 33.9%, and there was a notable reduction in the porosity of the sintered product.
Three-Dimensional Printing of Yttrium Oxide Transparent Ceramics via Direct Ink Writing
Authors: Chen Qiming , Li Huibing , Han Weijie , Yang Jian , Xu Wentao , Zhou Youfu
Published: July 2024

The utilization of 3D printing technology for the fabrication of intricate transparent ceramics overcomes the limitations associated with conventional molding processes, thereby presenting a highly promising solution. In this study, we employed direct ink writing (DIW) to prepare yttrium oxide transparent ceramics using a ceramic slurry with excellent moldability, solid content of 45 vol%, and shear-thinning behavior. A successfully printed transparent yttrium oxide ring measuring 30 mm in diameter, 10 mm in inner diameter, and 0.9 mm in thickness was obtained from the aforementioned slurry. After de-binding and sintering procedures, the printed ceramic exhibited in-line transmittance of 71% at 850 nm. This work not only produced complex yttria transparent ceramics with intricate shapes, but also achieved in-line transmittance that was comparable to that of the CIP method (79%), which can meet certain optical applications.
The Impact of Microwave Annealing on MoS2 Devices Assisted by Neural Network-Based Big Data Analysis
Authors: Su Xing , Cui Siwei , Zhang Yifei , Yang Hui , Wu Dongping
Published: July 2024

Microwave annealing, an emerging annealing method known for its efficiency and low thermal budget, has established a foundational research base in the annealing of molybdenum disulfide (MoS2) devices. Typically, to obtain high-quality MoS2 devices, mechanical exfoliation is commonly employed. This method’s challenge lies in achieving uniform film thickness, which limits the use of extensive data for studying the effects of microwave annealing on the MoS2 devices. In this experiment, we utilized a neural network approach based on the HSV (hue, saturation, value) color space to assist in distinguishing film thickness for the fabrication of numerous MoS2 devices with enhanced uniformity and consistency. This method allowed us to precisely assess the impact of microwave annealing on device performance. We discovered a relationship between the device’s electrical performance and the annealing power. By analyzing the statistical data of these electrical parameters, we identified the optimal annealing power for MoS2 devices as 700 W, providing insights and guidance for the microwave annealing process of two-dimensional materials.
Synthesis of Up-Conversion CaTiO3: Er3+ Films on Titanium by Anodization and Hydrothermal Method for Biomedical Applications
Authors: Tuyen Nguyen Thi Thanh , Tuan Ta Quoc , Toan Le Van , Tam Le Thi , Pham Vuong-Hung
Published: July 2024

The present study investigates the effects of Er3+ doping content on the microstructure and up-conversion emission properties of CaTiO3: Er3+ phosphors as a potential material in biomedical applications. The CaTiO3: x%Er3+ (x = 0.5, 1.0, 1.5, 2.0, 2.5, and 3.0%) films were synthesized on Ti substrates by a hydrothermal reaction at 200 °C for 24 h. The SEM image showed the formation of cubic nanorod CaTiO3: Er3+ films with a mean edge size value of (1–5) μm. When excited with 980 nm light, the CaTiO3: Er3+ films emitted a strong green band and a weak red band of Er3+ ions located at 543, 661, and 740 nm. The CaTiO3: Er3+ film exhibited excellent surface hydrophilicity with a contact angle of ~zero and good biocompatibility against baby hamster kidney (BHK) cells. CaTiO3: Er3+ films emerge as promising materials for different applications in the biomedical field.
Numerical and Experimental Study on Dummy Blade with Underplatform Damper
Authors: Li Di , Du Chenhong , Li Hongguang , Meng Guang
Published: July 2024

To confirm the variation in damping ratio offered by dry friction dampers against structural vibration stress, this study developed a blade vibration response test system for capturing damping characteristic curves through both frequency sweep excitation and damping-freevibration methods. The damping-free vibration method demonstrates high efficiency, allowing for the acquisition of a complete damping ratio characteristic curve in a single experiment. Experimental findings indicate that the two contact surfaces on the triangular prism damper produce distinct damping effects, closely aligning with the predicted damping characteristic curves. The peak damping ratio was found to be independent of the centrifugal load of the damper; dampers with varying contact areas produce approximately similar damping characteristics; and the damping effect shows a positive correlation with the root extension length.