bluuebunny/crossref_metadata_2025 huggingface dataset:
The effect of intermittent pneumatic compression on deep-vein thrombosis and ventilation-free days in critically ill patients with heart failure
Authors: Al-Dorzi Hasan M. , Al-Dawood Abdulaziz , Al-Hameed Fahad M. , Burns Karen E. A. , Mehta Sangeeta , Jose Jesna , Alsolamy Sami , Abdukahil Sheryl Ann I. , Afesh Lara Y. , Alshahrani Mohammed S. , Mandourah Yasser , Almekhlafi Ghaleb A. , Almaani Mohammed , Al Bshabshe Ali , Finfer Simon , Arshad Zia , Khalid Imran , Mehta Yatin , Gaur Atul , Hawa Hassan , Buscher Hergen , Lababidi Hani , Al Aithan Abdulsalam , Arabi Yaseen M.
Published: May 2022

There are contradictory data regarding the effect of intermittent pneumatic compression (IPC) on the incidence of deep-vein thrombosis (DVT) and heart failure (HF) decompensation in critically ill patients. This study evaluated the effect of adjunctive use of IPC on the rate of incident DVT and ventilation-free days among critically ill patients with HF. In this pre-specified secondary analysis of the PREVENT trial (N = 2003), we compared the effect of adjunctive IPC added to pharmacologic thromboprophylaxis (IPC group), with pharmacologic thromboprophylaxis alone (control group) in critically ill patients with HF. The presence of HF was determined by the treating teams according to local practices. Patients were stratified according to preserved (≥ 40%) versus reduced (< 40%) left ventricular ejection fraction, and by the New York Heart Association (NYHA) classification. The primary outcome was incident proximal lower-limb DVT, determined with twice weekly venous Doppler ultrasonography. As a co-primary outcome, we evaluated ventilation-free days as a surrogate for clinically important HF decompensation. Among 275 patients with HF, 18 (6.5%) patients had prevalent proximal lower-limb DVT (detected on trial day 1 to 3). Of 257 patients with no prevalent DVT, 11/125 (8.8%) patients in the IPC group developed incident proximal lower-limb DVT compared to 6/132 (4.5%) patients in the control group (relative risk, 1.94; 95% confidence interval, 0.74–5.08,p = 0.17). There was no significant difference in ventilator-free days between the IPC and control groups (median 21 days versus 25 days respectively,p = 0.17). The incidence of DVT with IPC versus control was not different across NYHA classes (pvalue for interaction = 0.18), nor across patients with reduced and preserved ejection fraction (pvalue for interaction = 0.15). Ventilator-free days with IPC versus control were also not different across NYHA classes nor across patients with reduced or preserved ejection fraction. In conclsuion, the use of adjunctive IPC compared with control was associated with similar rate of incident proximal lower-limb DVT and ventilator-free days in critically ill patients with HF.

Trial registration: The PREVENT trial is registered at ClinicalTrials.gov, ID: NCT02040103 (registered on 3 November 2013,https://clinicaltrials.gov/ct2/show/study/NCT02040103) and Current controlled trials, ID: ISRCTN44653506 (registered on 30 October 2013).
Baseline serum Krebs von den Lungen-6 as a biomarker for the disease progression in idiopathic pulmonary fibrosis
Authors: Chung Chiwook , Kim Jiwon , Cho Hyo Sin , Kim Ho Cheol
Published: May 2022

Disease progression (DP) is an important parameter for the prognosis of idiopathic pulmonary fibrosis (IPF). This study aimed to evaluate the baseline serum biomarkers for predicting the DP in IPF. Seventy-four patients who were diagnosed with IPF and had their serum Krebs von den Lungen-6 (KL-6) and monocyte count, which might be associated with prognosis of IPF, checked more than twice were included. KL-6 ≥ 1000 U/mL and monocyte ≥ 600/μL were arbitrarily set as the cut-off values for DP. The DP was defined as a 10% reduction in forced vital capacity, a 15% reduction in diffusing capacity of the lung for carbon monoxide relative to the baseline, or disease-related mortality. Of the 74 patients, 18 (24.3%) were defined as having DP. The baseline KL-6 level was significantly increased in the DP group compared to the stable disease group (median, 1228.0 U/mL vs. 605.5 U/mL, P = 0.019). Multivariate Cox analyses demonstrated that a high KL-6 level (KL-6 ≥ 1000 U/mL; hazard ratio, 2.761 or 2.845; P = 0.040 or 0.045) was independently associated with DP in each model. The baseline serum KL-6 level might be a useful biomarker for DP in IPF.
Origin of an antifreeze protein gene in response to Cenozoic climate change
Authors: Graham Laurie A. , Gauthier Sherry Y. , Davies Peter L.
Published: May 2022

Antifreeze proteins (AFPs) inhibit ice growth within fish and protect them from freezing in icy seawater. Alanine-rich, alpha-helical AFPs (type I) have independently (convergently) evolved in four branches of fishes, one of which is a subsection of the righteye flounders. The origin of this gene family has been elucidated by sequencing two loci from a starry flounder, Platichthys stellatus, collected off Vancouver Island, British Columbia. The first locus had two alleles that demonstrated the plasticity of the AFP gene family, one encoding 33 AFPs and the other allele only four. In the closely related Pacific halibut, this locus encodes multiple Gig2 (antiviral) proteins, but in the starry flounder, the Gig2 genes were found at a second locus due to a lineage-specific duplication event. An ancestral Gig2 gave rise to a 3-kDa “skin” AFP isoform, encoding three Ala-rich 11-a.a. repeats, that is expressed in skin and other peripheral tissues. Subsequent gene duplications, followed by internal duplications of the 11 a.a. repeat and the gain of a signal sequence, gave rise to circulating AFP isoforms. One of these, the “hyperactive” 32-kDa Maxi likely underwent a contraction to a shorter 3.3-kDa “liver” isoform. Present day starry flounders found in Pacific Rim coastal waters from California to Alaska show a positive correlation between latitude and AFP gene dosage, with the shorter allele being more prevalent at lower latitudes. This study conclusively demonstrates that the flounder AFP arose from the Gig2 gene, so it is evolutionarily unrelated to the three other classes of type I AFPs from non-flounders. Additionally, this gene arose and underwent amplification coincident with the onset of ocean cooling during the Cenozoic ice ages.
Apparent regional differences in the spectrum of BARD1 pathogenic variants in Spanish population and importance of copy number variants
Authors: Benito-Sánchez B. , Barroso A. , Fernández V. , Mercadillo F. , Núñez-Torres R. , Pita G. , Pombo L. , Morales-Chamorro R. , Cano-Cano J. M. , Urioste M. , González-Neira A. , Osorio A.
Published: May 2022

Only up to 25% of the cases in which there is a familial aggregation of breast and/or ovarian cancer are explained by germline mutations in the well-known BRCA1 and BRCA2 high-risk genes. Recently, the BRCA1-associated ring domain (BARD1), that partners BRCA1 in DNA repair, has been confirmed as a moderate-risk breast cancer susceptibility gene. Taking advantage of next-generation sequencing techniques, and with the purpose of defining the whole spectrum of possible pathogenic variants (PVs) in this gene, here we have performed a comprehensive mutational analysis of BARD1 in a cohort of 1946 Spanish patients who fulfilled criteria to be tested for germline pathogenic mutations in BRCA1 and BRCA2. We identified 22 different rare germline variants, being 5 of them clearly pathogenic or likely pathogenic large deletions, which account for 0.26% of the patients tested. Our results show that the prevalence and spectrum of mutations in the BARD1 gene might vary between different regions of Spain and expose the relevance to test for copy number variations.
A lightweight deep learning model for automatic segmentation and analysis of ophthalmic images
Authors: Sharma Parmanand , Ninomiya Takahiro , Omodaka Kazuko , Takahashi Naoki , Miya Takehiro , Himori Noriko , Okatani Takayuki , Nakazawa Toru
Published: May 2022

Detection, diagnosis, and treatment of ophthalmic diseases depend on extraction of information (features and/or their dimensions) from the images. Deep learning (DL) model are crucial for the automation of it. Here, we report on the development of a lightweight DL model, which can precisely segment/detect the required features automatically. The model utilizes dimensionality reduction of image to extract important features, and channel contraction to allow only the required high-level features necessary for reconstruction of segmented feature image. Performance of present model in detection of glaucoma from optical coherence tomography angiography (OCTA) images of retina is high (area under the receiver-operator characteristic curve AUC ~ 0.81). Bland–Altman analysis gave exceptionally low bias (~ 0.00185), and high Pearson’s correlation coefficient (p = 0.9969) between the parameters determined from manual and DL based segmentation. On the same dataset, bias is an order of magnitude higher (~ 0.0694, p = 0.8534) for commercial software. Present model is 10 times lighter than Unet (popular for biomedical image segmentation) and have a better segmentation accuracy and model training reproducibility (based on the analysis of 3670 OCTA images). High dice similarity coefficient (D) for variety of ophthalmic images suggested it’s wider scope in precise segmentation of images even from other fields. Our concept of channel narrowing is not only important for the segmentation problems, but it can also reduce number of parameters significantly in object classification models. Enhanced disease diagnostic accuracy can be achieved for the resource limited devices (such as mobile phone, Nvidia’s Jetson, Raspberry pi) used in self-monitoring, and tele-screening (memory size of trained model ~ 35 MB).
Irregular shape as an independent predictor of prognosis in patients with primary intracerebral hemorrhage
Authors: Liu Chunyang , Zhang Haopeng , Wang Lixiang , Jiang Qiuyi , Lu Enzhou , Yuan Chao , Liang Yanchao , Sun Zhenying , Xiang Huan , Xu Xun , Sun Jingxian , Fu Bo , Zhao Boxian , Zhang Daming , Chen Xin , Wang Ning , Wang Lu , Yang Guang
Published: May 2022

The utility of noncontrast computed tomography markers in the prognosis of spontaneous intracerebral hemorrhage has been studied. This study aimed to investigate the predictive value of the computed tomography (CT) irregularity shape for poor functional outcomes in patients with spontaneous intracerebral hemorrhage. We retrospectively reviewed all 782 patients with intracranial hemorrhage in our stroke emergency center from January 2018 to September 2019. Laboratory examination and CT examination were performed within 24 h of admission. After three months, the patient's functional outcome was assessed using the modified Rankin Scale. Multinomial logistic regression analyses were applied to identify independent predictors of functional outcome in patients with intracerebral hemorrhage. Out of the 627 patients included in this study, those with irregular shapes on CT imaging had a higher proportion of poor outcomes and mortality 90 days after discharge (P < 0.001). Irregular shapes were found to be significant independent predictors of poor outcome and mortality on multiple logistic regression analysis. In addition, the increase in plasma D-dimer was associated with the occurrence of irregular shapes (P = 0.0387). Patients with irregular shapes showed worse functional outcomes after intracerebral hemorrhage. The elevated expression level of plasma D-dimers may be directly related to the formation of irregular shapes.
Spin-orbit coupling effects on transport properties of electronic Lieb lattice in the presence of magnetic field
Authors: Sadeghi Elham , Rezania Hamed
Published: May 2022

In this paper, the transport properties of a two-dimensional Lieb lattice that is a line-centered square lattice are investigated in the presence of magnetic field and spin-orbit coupling. Specially, we address the temperature dependence of electrical and thermal conductivities as well as Seebeck coefficient due to spin-orbit interaction. We have exploited Green’s function approach in order to study thermoelectric and transport properties of Lieb lattice in the context of Kane–Mele model Hamiltonian. The results for Seebeck coefficient show the sign of thermopower is positive in the presence of spin-orbit coupling. Also the temperature dependence of transport properties indicates that the increase of spin-orbit coupling leads to decrease thermal conductivity however the decrease of gap parameter causes the reduction of thermal conductivity. There is a peak in temperature dependence of thermal conductivity for all values of magnetic fields and spin-orbit coupling strengths. Both electrical and thermal conductivities increase with increasing the temperature at low amounts of temperature due to the increasing of transition rate of charge carriers and excitation of them to the conduction bands. Also we have studied the temperature dependence of Seebeck coefficient of Lieb monolayer due to both spin orbit coupling and magnetic field factors in details.
No evidence of DUI in the Mediterranean alien species Brachidontes pharaonis (P. Fisher, 1870) despite mitochondrial heteroplasmy
Authors: Lubośny Marek , Śmietanka Beata , Arculeo Marco , Burzyński Artur
Published: May 2022

Two genetically different mitochondrial haplogroups ofBrachidontes pharaonis(p-distance 6.8%) have been identified in the Mediterranean Sea. This hinted at a possible presence of doubly uniparental inheritance in this species. To ascertain this possibility, we sequenced two complete mitogenomes ofBrachidontes pharaonismussels and performed a qPCR analysis to measure the relative mitogenome copy numbers of both mtDNAs. Despite the presence of two very similar regions composed entirely of repetitive sequences in the two haplogroups, no recombination between mitogenomes was detected. In heteroplasmic individuals, both mitogenomes were present in the generative tissues of both sexes, which argues against the presence of doubly uniparental inheritance in this species.
Selection of RNA-based evaluation methods for tumor microenvironment by comparing with histochemical and flow cytometric analyses in gastric cancer
Authors: Saito Noriyuki , Sato Yasuyoshi , Abe Hiroyuki , Wada Ikuo , Kobayashi Yukari , Nagaoka Koji , Kushihara Yoshihiro , Ushiku Tetsuo , Seto Yasuyuki , Kakimi Kazuhiro
Published: May 2022

Understanding the tumor microenvironment (TME) and anti-tumor immune responses in gastric cancer are required for precision immune-oncology. Taking advantage of next-generation sequencing technology, the feasibility and reliability of transcriptome-based TME analysis were investigated. TME of 30 surgically resected gastric cancer tissues was analyzed by RNA-Seq, immunohistochemistry (IHC) and flow cytometry (FCM). RNA-Seq of bulk gastric cancer tissues was computationally analyzed to evaluate TME. Computationally analyzed immune cell composition was validated by comparison with cell densities established by IHC and FCM from the same tumor tissue. Immune cell infiltration and cellular function were also validated with IHC and FCM. Cell proliferation and cell death in the tumor as assessed by RNA-Seq and IHC were compared. Computational tools and gene set analysis for quantifying CD8+ T cells, regulatory T cells and B cells, T cell infiltration and functional status, and cell proliferation and cell death status yielded an excellent correlation with IHC and FCM data. Using these validated transcriptome-based analyses, the immunological status of gastric cancer could be classified into immune-rich and immune-poor subtypes. Transcriptome-based TME analysis is feasible and is valuable for further understanding the immunological status of gastric cancer.
Average relative flow of single-wing labyrinth drip irrigation tape based on projection pursuit regression
Authors: Tao Hongfei , Tao Juanqin , Li Qiao , Aihemaiti Mahemujiang , Jiang Youwei , Yang Wenxin , Wei Jianqun
Published: May 2022

The hydraulic performance of single-wing labyrinth drip irrigation tapes under the coupling effect of water and fertilizer affects the operating efficiency of the entire drip irrigation system. In this study, three types of single-wing labyrinth drip irrigation tapes were studied. We evaluated the average relative flow of each type and conducted indoor uniform orthogonal tests of three factors, namely, fertilizer concentration, sediment content, and operating pressure. The results showed that the order of the factors affecting the average relative flow of single-wing labyrinth drip irrigation tape was sediment content > fertilizer concentration > operating pressure. The projection pursuit regression (PPR) models of the average relative flow of three types of single-wing labyrinth drip irrigation tapes (H1, H2, and H3) were established. The root mean square errors (nRMSE) of these three models were 0.66%, 0.74%, 0.34%, respectively, indicating their excellent prediction performance. The optimal performance of the three types of tapes were obtained when the fertilizer concentration was 0.6 g/L, the sediment content was 1 g/L, and the operating pressure was 40 kPa. Under the optimal condition, the average relative flows of H1-type, H2-type, and H3-type were 0.792, 0.764, and 0.700, respectively.
Fruit/Juice Quality Assessment Using Spectroscopic Data Analysis
Authors: Moncada-Basualto M. , Pozo-Martínez J. , Olea-Azar C.
Published: May 2022

The food industry involves all activities connected with the production, storage, processing and distribution of different food products, complying with strict quality parameters at each stage. Spectroscopic techniques together with statistical analysis provide a useful tool for the food industry, to ensure the quality of food and deliver added value to beneficial properties for health. This chapter describes spectroscopic techniques for the analysis of fruits and juices.
Application of FTIR Spectroscopy and Chromatography in Combination With Chemometrics for the Quality Control of Olive Oil
Authors: Indrayanto Gunawan , Rohman Abdul
Published: May 2022

Edible fats and oils are essential for the human diet because they contain nutritional sources needed for daily life. However, owing to price discrepancies, some unethical sellers may adulterate expensive oils with lower quality oils. Olive oils (OOs) are valuable oils commanding high prices in the fats and oils industry, therefore OOs are commonly subjected to adulteration. Hence the development of analytical methods capable of detecting the adulteration of OOs has been under active investigation. Some official methods have been used for the quality control of OOs, such as gas chromatography with flame ionization detection for identifying fatty acid (FA) composition. All edible oils are characterized by specific parameters, including FA composition. The compositional difference of FAs in original OOs may indicate that there has been adulteration. In addition to official methods, some alternative methods such as Fourier transform infrared (FTIR) spectroscopy have been developed and validated for the quality control and authentication of OOs.
Application of Molecular Spectroscopy and Chromatography in Combination with Chemometrics for the Authentication of Virgin Coconut Oil
Authors: Windarsih Anjar , Lestari Lily Arsanti , Erwanto Yuny , Fadzillah Nurrulhidayah Ahmad , Rohman Abdul
Published: May 2022

Coconut oil and virgin coconut oil can be considered as functional food oils owing to their beneficial effects on human health. Coconut oils command a high price in the fats and oils industry, hence they may be subjected to adulteration with cheaper oils such as palm oil. As a consequence, the development and standardization of analytical methods intended for the authentication of coconut oils are necessary. In this context, some instrumental techniques based on spectroscopic and chromatographic methods in combination with multivariate data analysis (chemometrics) have been used successfully for the authentication of coconut oils.
Application of Molecular Spectroscopy and Chromatography in Combination with Chemometrics for the Authentication of Cod Liver Oil
Authors: Hastuti Agustina A. M. B. , Rohman Abdul
Published: May 2022

Cod liver oil (CLO) is a fish oil commonly used in pharmaceutical and food supplement products. CLO is acknowledged as a functional oil owing to its capability to provide some health benefit effects. It is known as a good source of vitamins and essential fatty acids, especially omega-3 (ω-3) and omega-6 (ω-6) fatty acids such as eicosapentaenoic acid (EPA, C20:5 ω-3) and docosahexaenoic acid (DHA, C22:6 ω-3), hence it commands a high price in the fats and oils industry. Some analytical methods for the authentication of CLO have been reported, including Fourier transform infrared spectroscopy, NMR spectroscopy, and chromatography-based methods. These methods in combination with chemometric techniques were successful for the identification and classification of CLO and CLO adulterated with other animal fats and vegetable oils having a lower price than CLO.
Breath odor-based individual authentication by an artificial olfactory sensor system and machine learning
Authors: Jirayupat Chaiyanut , Nagashima Kazuki , Hosomi Takuro , Takahashi Tsunaki , Samransuksamer Benjarong , Hanai Yosuke , Nakao Atsuo , Nakatani Masaya , Liu Jiangyang , Zhang Guozhu , Tanaka Wataru , Kanai Masaki , Yasui Takao , Baba Yoshinobu , Yanagida Takeshi
Published: May 2022

The potential feasibility of breath odor sensing-based individual authentication was demonstrated by a 16-channel chemiresistive sensor array and machine learning.
Multicharged cyclodextrin supramolecular assemblies
Authors: Liu Zhixue , Liu Yu
Published: May 2022

This review provides an overview of multicharged cyclodextrin supramolecular assemblies, including their assembly mechanisms and broad applications in chemistry, materials science, medicine, biological science, catalysis, and other fields.
Toward controlling the Al2O3/ZnO interface properties by in situ ALD preparation
Authors: Janowitz Christoph , Mahmoodinezhad Ali , Kot Małgorzata , Morales Carlos , Naumann Franziska , Plate Paul , Zoellner Marvin Hartwig , Bärwolf Florian , Stolarek David , Wenger Christian , Henkel Karsten , Flege Jan Ingo
Published: May 2022

The electronic band alignment of an alumina/zinc oxide thin-film heterostructure solely grown by atomic layer deposition has been determined by XPS/UPS depth profiling, correlating the electronic properties with the interface chemical composition.
A core–shell liquid metal-Cu nanoparticle with glutathione consumptionviaanin situreplacement strategy for tumor combination treatment of chemodynamic, microwave dynamic and microwave thermal therapy
Authors: Yu Yongnian , Wu Qiong , Niu Meng , Gou Li , Tan Longfei , Fu Changhui , Ren Xiangling , Ren Jun , Zheng Yongfa , Meng Xianwei
Published: May 2022

A stable core–shell spherical “storage pool” was obtained, which could realize the combination of chemodynamic, microwave dynamic and microwave thermal therapy.
Zero-dimensional hybrid binuclear manganese chloride with thermally stable yellow emission
Authors: Zhang Liming , Luo Zhishan , Wei Yi , Wang Wei , Liu Yulian , Li Chen , He Xin , Quan Zewei
Published: May 2022

A novel 0D hybrid manganese chloride [Pb(C12H24O6)Cl]2[Mn2Cl6] (PMC) with near-unity yellow emission is reported. PMC exhibits superior photoluminescence thermal stability up to 450 K.
Crippling the C70 fullerene: non-classical C68Cl26(OH)2 and C68Cl25(OH)3 with three heptagons and only fused pentagons via chlorination-promoted skeletal transformations
Authors: Brotsman Victor A. , Ioffe Ilya N. , Troyanov Sergey I.
Published: May 2022

High-temperature chlorination of C70 with SbCl5 promotes a five-step skeletal transformation that gives partially hydrolyzed C68Cl28 with an unprecedented carbon cage featuring three heptagons and 15 pentagons arranged in fused pairs and triples.
A receptor-targeting AIE photosensitizer for selective bacterial killing and real-time monitoring of photodynamic therapy outcome
Authors: Wang Cheng , Wang Jiaxin , Xue Ke , Xiao Minghui , Sun Zhencheng , Zhu Chunlei
Published: May 2022

A receptor-targeting AIE photosensitizer is reported for selective killing of Gram-positive bacteria with real-time feedback on the therapeutic outcome.
Correction: Breath odor-based individual authentication by an artificial olfactory sensor system and machine learning
Authors: Jirayupat Chaiyanut , Nagashima Kazuki , Hosomi Takuro , Takahashi Tsunaki , Samransuksamer Benjarong , Hanai Yosuke , Nakao Atsuo , Nakatani Masaya , Liu Jiangyang , Zhang Guozhu , Tanaka Wataru , Kanai Masaki , Yasui Takao , Baba Yoshinobu , Yanagida Takeshi
Published: May 2022

Correction for ‘Breath odor-based individual authentication by an artificial olfactory sensor system and machine learning’ by Chaiyanut Jirayupat et al., Chem. Commun., 2022, DOI: https://doi.org/10.1039/D1CC06384G.
Correction: Lead(ii) supramolecular structures formed through a cooperative influence of the hydrazinecarbothioamide derived and ancillary ligands
Authors: García-Santos Isabel , Castiñeiras Alfonso , Mahmoudi Ghodrat , Babashkina Maria G. , Zangrando Ennio , Gomila Rosa M. , Frontera Antonio , Safin Damir A.
Published: May 2022

Correction for ‘Lead(ii) supramolecular structures formed through a cooperative influence of the hydrazinecarbothioamide derived and ancillary ligands’ by Isabel García-Santos et al., CrystEngComm, 2022, 24, 368–378, https://doi.org/10.1039/D1CE01251G.
Sizable magnetic entropy change in bismuth-substituted La0.75Bi0.1Na0.15MnO3 manganite
Authors: Mendonca Lozil Denzil , Murari M. S. , Daivajna Mamatha D
Published: May 2022

The sample La0.75Bi0.1Na0.15MnO3 exhibits large ΔSMaxm of 4.4 J kg−1 K−1 near room temperature (RT) at low field of 1.5 T (LF). The coexistence of long and short-range interactions leading to first order like phase transition is responsible for LFRT magnetic entropy change.
Highly selective synthesis of multicarbon compounds by carbon dioxide hydrogenation over Pt nanocrystals anchoring Ru clusters
Authors: Yu Yulv , Cai Yichen , Liang Minghui , Tan Xin , Huang Jin , Kotegawa Fukue , Li Zezhou , Zhou Jihan , Jiang Hong , Harada Masafumi , Wang Yuan
Published: May 2022

Carbon supported Pt nanocrystals anchoring small Ru nanoclusters (Ru-co-Pt/C) could catalyze CO2 hydrogenation to form multi-carbon compounds (C2–C26) with an extraordinary C2+ selectivity of 90.1% at 130 °C.
Designing bifunctional platforms for LED devices and luminescence lifetime thermometers: a case of non-rare-earth Mn4+ doped tantalate phosphors
Authors: Wu Zhaojie , Li Li , Li Hong , Mei Lingsong , Xia Weidi , Yi Yousheng , Hua Yongbin
Published: May 2022

Non-rare-earth Mn4+ doped tantalate (Sr2GdTaO6) phosphors exhibiting deep-red emission were synthesized.
Convenient construction of polycyclic architectures via multicomponent reaction of amino acids, dialkyl but-2-ynedioates and 2-(o-hydroxyarylidene)-1,3-indanediones
Authors: Liu Xueyan , Sun Jing , Yan Chao-Guo
Published: May 2022

Unique polyheterocyclic compounds were efficiently synthesized by cascade reaction of the in situ generation of a special kind of azomethine ylide, 1,3-dipolar cycloaddition and annulation of phenoxide.
A rhodamine–TPE scaffold-based fluorescent probe for visualizing phosgene with a portable smartphone via test TLC strips
Authors: Yin Shuai , Zhang Shishen , Han Yifeng
Published: May 2022

A rhodamine–TPE scaffold-based ratiometric signal readout probe was developed for sensitive, rapid, and in situ phosgene determination.
Pt–Cu nanoalloy catalysts: compositional dependence and selectivity for direct electrochemical oxidation of formic acid
Authors: Pushpalatha Nataraj , Abraham Elezabeth V. , Saravanan Govindachetty
Published: May 2022

A PtCu3 nanoalloy catalyst showed much enhanced catalytic activity for the direct electrochemical oxidation of formic acid compared to a commercial platinum catalyst.
Correction: Ultrasmall Prussian blue nanoparticles attenuate UVA-induced cellular senescence in human dermal fibroblasts via inhibiting the ERK/AP-1 pathway
Authors: Li Yueyue , Zeng Ni , Qin Zhiguo , Chen Yihe , Lu Qian , Cheng Yuxin , Xia Qingyue , Lu Zhiyu , Gu Ning , Luo Dan
Published: May 2022

Correction for ‘Ultrasmall Prussian blue nanoparticles attenuate UVA-induced cellular senescence in human dermal fibroblasts via inhibiting the ERK/AP-1 pathway’ by Yueyue Li et al., Nanoscale, 2021, 13, 16104–16112, https://doi.org/10.1039/D1NR04268H.
Synthesis and Optical Properties of Excited-State Intramolecular Proton Transfer (ESIPT) Emitters with Sulfobetaine Fragments
Authors: Munch Maxime , Ulrich Gilles , Massue Julien
Published: May 2022

This article describes the synthetic efforts towards the solubilization of organic fluorescent emitters based on a 2-(2′-hydroxybenzofuranyl)benzazole (HBBX) scaffold in aqueous media under physiological conditions (PBS, pH 7.4).
Synthesis of an ABC triblock copolymer by a bilateral Click reaction using α,ω-bifunctionalized poly(3-hexylthiophene) as an inner segment
Authors: Inagaki Shin , Higashihara Tomoya
Published: May 2022

A novel A-b-poly(3-hexylthiophene)(P3HT)-b-C type triblock copolymer was successfully synthesized by the bilateral Cu-catalyzed azide alkyne cycloaddition reaction using α,ω-bifunctionalized P3HT.
Correction: An engineered third electrostatic constriction of aerolysin to manipulate heterogeneously charged peptide transport
Authors: Niu Hongyan , Li Meng-Yin , Ying Yi-Lun , Long Yi-Tao
Published: May 2022

Correction for ‘An engineered third electrostatic constriction of aerolysin to manipulate heterogeneously charged peptide transport’ by Hongyan Niu et al., Chem. Sci., 2022, 13, 2456–2461, https://doi.org/10.1039/D1SC06459B.
NAD-catabolizing ectoenzymes of Schistosoma mansoni
Authors: Nation Catherine S. , Da'Dara Akram A. , Skelly Patrick J.
Published: May 2022

Infection with schistosomes (blood flukes) can result in the debilitating disease schistosomiasis. These parasites survive in their host for many years, and we hypothesize that proteins on their tegumental surface, interacting with the host microenvironment, facilitate longevity. One such ectoenzyme — the nucleotide pyrophosphatase/phosphodiesterase SmNPP5 can cleave ADP (to prevent platelet aggregation) and NAD (likely preventing Treg apoptosis). A second tegumental ectoenzyme, the glycohydrolase SmNACE, also catabolizes NAD. Here, we undertake a comparative biochemical characterization of these parasite ectoenzymes. Both are GPI-linked and exhibit different optimal pH ranges. While SmNPP5 requires divalent cations, SmNACE does not. The KM values of the two enzymes for NAD at physiological pH differ: SmNPP5, KM = 340 µM ± 44; SmNACE, KM = 49 µM ± 4. NAD cleavage by each enzyme yields different products. SmNPP5 cleaves NAD to form nicotinamide mononucleotide (NMN) and AMP, whereas SmNACE cleaves NAD to generate nicotinamide (NAM) and adenosine diphosphate ribose (ADPR). Each enzyme can process the other's reaction product. Thus, SmNACE cleaves NMN (to yield NAM and ribose phosphate) and SmNPP5 cleaves ADPR (yielding AMP and ribose phosphate). Metabolomic analysis of plasma containing adult worms supports the idea that these cleavage pathways are active in vivo. We hypothesize that a primary function of SmNPP5 is to cleave NAD to control host immune cell function and a primary function of SmNACE is to cleave NMN to generate the vital nutrient nicotinamide (vitamin B3) for convenient uptake by the worms. Chemical inhibition of one or both ectoenzymes could upset worm metabolism and control schistosome infection.
Silencing GOLGA8B inhibits cell invasion and metastasis by suppressing STAT3 signaling pathway in lung squamous cell carcinoma
Authors: Li Zhanzhan , Li Yanyan , Li Na , Shen Liangfang , Liu Aibin
Published: May 2022

Changes to some Golgi subfamily member proteins are reported to be involved in tumor metastasis. However, the functional role and potential mechanism of the Golgi A8 family member B (GOLGA8B) in lung squamous cell carcinoma (LUSC) remains unknown. In the present study, GOLGA8B expression was detected using qRT-PCR, Western blot, and immunohistochemistry (IHC). In vivo animal experiments and in vitro functional assays were performed to explore the function of GOLGA8B in LUSC. Luciferase assays were performed to investigate the underlying targets of GOLGA8B in LUSC. GOLGA8B was shown to be highly expressed in LUSC metastasis tissue, and significantly associated with the distant metastasis-free survival of LUSC patients. Loss-of-function assays indicated that silencing GOLGA8B suppressed LUSC cell tumorigenesis in vivo and weakened in vitro invasion and migration. GOLGA8B silencing-induced inhibition of invasion and migration was associated with the inactivation of STAT3 signaling. Importantly, these results showed that the number of circulating tumor cells (CTCs) was markedly higher in the GOLGA8B silencing group than in the control vector group. GOLGA8B expression was positively associated with p-STAT3 expression in LUSC tissue. Study findings revealed a novel mechanism by which GOLGA8B promotes tumor metastasis in LUSC cells and suggests that this protein could be a promising target for antitumor metastasis therapy in LUSC patients.
Design of impedance matching network based on optimized real frequency algorithm
Authors: Bai Bo , Chen Riliang , Yuan Kai , Tang Rongxin , Zhao Ziyang , Lin Hai , Wang Yuhao , Deng Xiaohua
Published: May 2022

In the recent couple of decades, some multifunctional spaceborne active radars had been launched. Those radars used to be broadband radars using dipole transmitting antennas. The odd‐order resonant frequency of the antenna does not completely cover the operating frequency of the entire radar, so this may cause the antenna's radiation efficiency to deteriorate. The typical method to solve this problem was to design an impedance matching network system for broadband antennas to achieve a good voltage standing wave ratio and transmit power gain. In this paper, a new optimized real‐frequency method was designed, and a 0.4‐meter dipole antenna was tested before and after impedance matching. The measured results showed that the impedance matching network obtained by the optimized real‐frequency method proposed in this paper can improve the antenna radiation efficiency, and can effectively reduce the standing wave ratio to avoid damage to the transmitter caused by high echo power.
Improved coordinated control for thyristor controlled series compensation and generator excitation
Authors: Li Jian , Zhao Zhengnan , Su Qingyu
Published: May 2022

This article improves the coordinated passivation control strategy of a single machine infinite bus system with generator excitation and thyristor controlled series compensation. First, in the traditional coordinated passivation control strategy, class − κ functions and an integral term are introduced to improve the convergence speed and reduce the steady‐state error of the system. Furthermore, an adaptive control method based on sliding mode is used to design adaptive laws for uncertain parameters and external disturbances and simplify the controller form. Finally, the simulation results show that compared with the traditional coordinated passivation method, the proposed controller has stronger robust adaptability and improves the convergence rate and transient performance of the system.
Simulation and experimental analysis of three‐dimensional temperature distribution of ±400‐kV converter transformer valve‐side resin impregnated paper bushing under high current
Authors: Xie Gengsheng , Shi Shifeng , Wang Qingyu , Liu Peng , Peng Zongren
Published: May 2022

In order to cope with the current engineering demand for increasing the current‐carrying capacity of resin impregnated paper (RIP) bushing, an optimization scheme of RIP bushing was proposed in this paper. Simulation and experimental studies were carried out to verify the rationality of the scheme. An improved simulation method was proposed. To ensure as much accuracy as possible, the physical model of simulation considers the influence of heat conduction, thermal convection and thermal radiation process according to the actual operation environment. To boost the computational efficiency, the improved method simplified the relationship between temperature and heating power of the current‐carrying conductor as a fitting formula to avoid the iterative calculation between electromagnetic field simulation and temperature field simulation. The temperature rise test was carried out according to the engineering requirement and the standard international electro technical commission (IEC) 60137:2008. The simulation and experimental results show that the RIP bushing can carry a current with the heating power of its conductor equivalent to that generated by a 50‐Hz current of 6736 A while running in a converter station. It is a breakthrough of the current‐carrying capacity of high voltage bushing. Meanwhile, the regularity of temperature distribution of the RIP bushing was discussed.
Study on the energy stability region of DFIG‐integrated power system with virtual inertia
Authors: Ma Jing , Zhou Yi , Shen Yaqi , Du Yanling , Wang Jingran , Sun Sujuan , Huang Yuanyan , Zhao Shuqiang
Published: May 2022

Currently available research on the oscillatory stability of doubly‐fed induction generator (DFIG) integrated power system can hardly depict the dynamic characteristics of DFIGs with inertia support capability. The dynamic energy stability region of DFIG‐integrated power system with virtual inertia is constructed in this paper. First, a dynamic model of the wind farm is built and the dynamic energy function of DFIG during oscillation is derived. The dissipation energy model of DFIG‐integrated power system is established, and the functional relationship between the dissipation energy and the critical energy of the system is explored. Then, the dynamic energy stability region of DFIG‐integrated power system is constructed according to the energy curve formed by the critical energy points. Based on this, the effects of the virtual inertia and PLL control parameters on the energy stability region are revealed. Simulation tests performed in RTDS verify that, the proposed method is applicable to the system with multiple oscillation modes. It can effectively evaluate the tolerance of the system to disturbances, and can quantitatively analyze the effects of the control parameters on the energy stability regions of intra‐area and inter‐area oscillation modes.
Retracted: Robotic Process Automation use cases in academia and early implementation experiences
Authors: Gupta Ankur , Prabhat Purnendu , Sawhney Sahil , Gupta Rajesh , Tanwar Sudeep , Kumar Neeraj , Shabaz Mohammad
Published: May 2022

Retraction: [Ankur Gupta, Purnendu Prabhat, Sahil Sawhney, Rajesh Gupta, Sudeep Tanwar, Neeraj Kumar, Mohammad Shabaz, Robotic Process Automation use cases in academia and early implementation experiences, IET Software 2022 (https://doi.org/10.1049/sfw2.12061)].

The above article from IET Software, published online on 19 May 2022 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the Editor‐in‐Chief, Hana Chockler, the Institution of Engineering and Technology (the IET) and John Wiley and Sons Ltd. This article was published as part of a Guest Edited special issue. Following an investigation, the IET and the journal have determined that the article was not reviewed in line with the journal’s peer review standards and there is evidence that the peer review process of the special issue underwent systematic manipulation. Accordingly, we cannot vouch for the integrity or reliability of the content. As such we have taken the decision to retract the article. The authors have been informed of the decision to retract.
Predicting HCN, HCO+, multi-transition CO, and dust emission of star-forming galaxies
Authors: Lizée T. , Vollmer B. , Braine J. , Gratier P. , Bigiel F.
Published: May 2022

The interstellar medium is a turbulent, multiphase, and multi-scale medium that follows scaling relations that link the surface density, volume density, and velocity dispersion with the cloud size. Galactic clouds range from below 1 pc to about 100 pc in size. Extragalactic clouds appear to follow the same range, although they are only now becoming observable in atomic and molecular lines. Analytical models of galactic gaseous disks need to take the multi-scale and multiphase nature of the interstellar medium into account. They can be described as clumpy star-forming accretion disks in vertical hydrostatic equilibrium, with the mid-plane pressure balancing the gravity of the gaseous and stellar disk. Interstellar medium turbulence is taken into account by applying Galactic scaling relations to the cold atomic and molecular gas phases. Turbulence is maintained through energy injection by supernovae. With the determination of the gas mass fraction at a given spatial scale, the equilibrium gas temperature between turbulent heating and line cooling, the molecular abundances, and the molecular line emission can be calculated. The resulting model radial profiles of infrared, HI, CO, HCN, and HCO+ emission are compared to THINGS, HERACLES, EMPIRE, SINGS, and GALEX observations of 17 local spiral galaxies. The model free parameters were constrained for each galactic radius independently. The Toomre parameter, which measures the stability against star formation (cloud collapse), exceeds unity in the inner disk of a significant number of galaxies. In two galaxies it also exceeds unity in the outer disk. Therefore, in spiral galaxies Qtot = 1 is not ubiquitous. The model gas velocity dispersion is consistent with the observed HI velocity dispersion where available. Within our model, HCN and HCO+ is already detectable in relatively low-density gas (∼1000 cm−3). We derive CO and HCN conversion factors and molecular gas depletion times. Both conversion factors are consistent with values found in the literature. Whereas in the massive galaxies the viscous timescale greatly exceeds the star-formation timescale, the viscous timescale is smaller than the star-formation timescale within R ∼ 2 Rd, the disk scale length, in the low-mass galaxies. We suggest that massive spiral galaxies undergo starvation in the absence of gas accretion from the halo, whereas in low-mass galaxies the fuel for star formation reaches R ∼ 2 Rd from outside via a thick gas disk component with a high radial infall velocity observable in the HI line.
Cold dark matter protohalo structure around collapse: Lagrangian cosmological perturbation theory versus Vlasov simulations
Authors: Saga Shohei , Taruya Atsushi , Colombi Stéphane
Published: May 2022

We explore the structure around the shell-crossing time of cold dark matter protohaloes seeded by two or three crossed sine waves of various relative initial amplitudes, by comparing Lagrangian perturbation theory (LPT) up to the tenth order with high-resolution cosmological simulations performed with the public Vlasov code ColDICE. Accurate analyses of the density, the velocity, and related quantities such as the vorticity are performed by exploiting the fact that ColDICE can follow the phase-space sheet locally at the quadratic level. To test LPT predictions beyond the shell-crossing, we employ a ballistic approximation, which assumes that the velocity field is frozen just after the shell-crossing. In the generic case, where the amplitudes of the sine waves are all different, high-order LPT predictions match the exact solution very well, even beyond collapse. As expected, convergence slows down when going from quasi-1D dynamics, where one wave dominates over the two others, to the axial-symmetric configuration, where all the amplitudes of the waves are equal. We also notice that LPT convergence is slower when considering velocity-related quantities. Additionally, the structure of the system at and beyond collapse given by LPT and the simulations agrees very well with singularity theory predictions, in particular with respect to the caustic and vorticity patterns that develop beyond collapse. Again, this does not apply to axial-symmetric configurations, which are still correct from the qualitative point of view, but rather when multiple foldings of the phase-space sheet produce very high density contrasts and hence a strong back-reaction of the gravitational force.
Water, hydrogen cyanide, carbon monoxide, and dust production from distant comet 29P/Schwassmann-Wachmann 1
Authors: Bockelée-Morvan D. , Biver N. , Schambeau C. A. , Crovisier J. , Opitom C. , de Val Borro M. , Lellouch E. , Hartogh P. , Vandenbussche B. , Jehin E. , Kidger M. , Küppers M. , Lis D. C. , Moreno R. , Szutowicz S. , Zakharov V.
Published: May 2022

Context. 29P/Schwassmann-Wachmann 1 is a distant Centaur/comet, showing persistent CO-driven activity and frequent outbursts.

Aims. We aim to better characterize its gas and dust activity from multiwavelength observations performed during outbursting and quiescent states.

Methods. We used the HIFI, PACS and SPIRE instruments of the Herschel space observatory on several dates in 2010, 2011, and 2013 to observe the H2O 557 GHz and NH3 573 GHz lines and to image the dust coma in the far-infrared. Observations with the IRAM 30 m telescope were undertaken in 2007, 2010, 2011, and 2021 to monitor the CO production rate through the 230 GHz line, and to search for HCN at 89 GHz. The 70 and 160 µm PACS images were used to measure the thermal flux from the nucleus and the dust coma. Modeling was performed to constrain the size of the sublimating icy grains and to derive the dust production rate.

Results. HCN is detected for the first time in comet 29P (at 5σ in the line area). H2O is detected as well, but not NH3. H2O and HCN line shapes differ strongly from the CO line shape, indicating that these two species are released from icy grains. CO production rates are in the range (2.9–5.6) × 1028 s−1 (1400–2600 kg s−1). A correlation between the CO production rate and coma brightness is observed, as is a correlation between CO and H2O production. The correlation obtained between the excess of CO production and excess of dust brightness with respect to the quiescent state is similar to that established for the continuous activity of comet Hale-Bopp. The measured Q(H2O)/Q(CO) and Q(HCN)/Q(CO) production rate ratios are 10.0 ± 1.5 % and 0.12 ± 0.03 %, respectively, averaging the April-May 2010 measurements (Q(H2O) = (4.1 ± 0.6) × 1027 s−1, Q(HCN) = (4.8 ± 1.1) × 1025 s−1). We derive three independent and similar values of the effective radius of the nucleus, ~31 ± 3 km, suggesting an approximately spherical shape. The inferred dust mass-loss rates during quiescent phases are in the range 30–120 kg s−1, indicating a dust-to-gas mass ratio <0.1 during quiescent activity. We conclude that strong local heterogeneities exist on the surface of 29P, with quenched dust activity from most of the surface, but not in outbursting regions.

Conclusions. The volatile composition of the atmosphere of 29P strongly differs from that of comets observed within 3 au from the Sun. The observed correlation between CO, H2O and dust activity may provide important constraints for the outburst-triggering mechanism.