bluuebunny/crossref_metadata_2025 huggingface dataset:
Lateral Rhinotomy for a Large, Infected Haller Cell Causing Proptosis
Authors: Ghosh Debangshu , Baruah Dilip Kumar , Goswmi Subodh Chandra , Basu Sumit  Kumar
Published: April 2019

Objective: To report a case of a large sinus Haller cell that presented with chronic rhinosinusitis and proptosis and its surgical management.

Method:

            Design:            Case Report

            Setting:            Tertiary Government Hospital

            Participants:    One (1)

Results: A 34-year-old lady with proptosis and secondary sinusitis due to a giant infected Haller cell was successfully treated by lateral rhinotomy approach and clearance of all diseased mucosa therein into the nasal cavity.

Conclusion: Approach to diseased sinonasal structures via lateral rhinotomy is an alternative to endoscopic sinus surgery in the presence of an unusually large Haller cell.

Keywords: Haller cell.  proptosis. maxillary sinusitis.  lateral rhinotomy.
Otorhinolaryngologic Manifestations of Human Immunodeficiency Virus Infection in Manila, the Philippines
Authors: Arriola Anna Carlissa P. , Chua Antonio H. , Tactacan-Abrenica Rosario Jessica F.
Published: April 2019

Objective: To determine the prevalence of otorhinolaryngologic (ENT) manifestations in people living with Human Immunodeficiency Virus (HIV) infection seen in our institutions, and to determine the association of these manifestations with age, sex, CD4 count and antiretroviral treatment.

Methods:

Study Design: Cross-Sectional Study

Setting: Two Tertiary Government Hospitals

Subjects: Adult patients (>19 years old) confirmed to be HIV- infected  were seen at Jose R. Reyes Memorial Medical Center and San Lazaro Hospital from February to July 2014. A data sheet regarding ENT manifestations was filled upon examination. Age, sex, CD4 count and antiretroviral treatment data were recorded. Independent samples t-test was used to determine age association with manifestations. Fischer’s exact test was used to determine association of sex and manifestations. Chi-square test of independence was used to determine association of CD4 count and antiretroviral treatment with manifestations. Association was considered statistically significant if p< 0.05.

Results: Three hundred one patients participated with 287 males (95.3%) and 14 females (4.7%). The mean age was 31.7 ± 8. One hundred ninety seven (65.4%) had ENT manifestations. The most common areas of manifestations came from the oral cavity-oropharyngeal area (n=104, 37%), nasal cavity-nasopharyngeal area (n=73, 26%) and ear (n=43, 15%). The most frequent manifestations were cervical lymphadenopathy, aphthous stomatitis and acute rhinitis. There was no significant difference in the age (p=0.31) and sex (p=0.15) of patients with and without manifestations. However, there was a direct association of manifestations with low CD4 count (p<0.001) and inverse association with antiretroviral treatment (p=0.036).

Conclusion: Our findings emphasize the importance of screening for ENT manifestations, regular CD4 monitoring and enrollment to antiretroviral therapy in persons with HIV. Baseline otorhinolaryngologic examination upon HIV diagnosis and prior to initiating treatment should be followed by regular surveillance. Conversely, physicians should also be aware that patients with ENT manifestation may have HIV infection.

Keywords:   HIV, Otorhinolaryngologic diseases, CD4 Lymphocyte Count, Anti-Retroviral Agents, Stomatitis, Rhinitis
Sinonasal Ameloblastic Carcinoma in a 50-Year-Old Filipino Female
Authors: Del Mundo Daryl Anne A.
Published: April 2019

Objective: To report the possible malignant transformation of primary sinonasal ameloblastoma into sinonasal ameloblastic carcinoma.

Methods:

Design: Case Report

Setting: Tertiary Public University Hospital

Patient: One (1)

Result: A 50-year-old woman with a previous diagnosis of sinonasal ameloblastoma reported recurrence of symptoms of right-sided nasal obstruction and epistaxis two years after endoscopic sinus surgery. Clinical examination, CT scans, and subsequent total maxillectomy with orbital exenteration revealed a left intranasal mass with maxillary, ethmoid, and orbital floor extension and pulmonary and hepatic metastases.  Histopathologic findings of palisading columnar epithelium with reverse polarity with malignant features were consistent with ameloblastic carcinoma. Despite subsequent cycles of chemotherapy, the patient died two years after surgery. To the best of our knowledge, there have been no published reports of a primary sinonasal ameloblastoma with malignant transformation in the English literature.

Conclusion: Ameloblastic carcinoma is a rare neoplasm which may arise de novo or from malignant transformation of an ameloblastoma. Because ameloblastoma is commonly encountered in our setting, clinicians should be aware of this possibility and closely follow their patients accordingly.

Keywords: sinonasal, maxillary, ameloblastic carcinoma, malignant transformation
The Effectiveness of Intravenous Tranexamic Acid on Blood Loss and Surgical Time During Endoscopic Sinus Surgery: A Systematic Review
Authors: Ligon Jona Minette E. , Almazan Natividad A.
Published: April 2019

Objective: To review the effectiveness of intravenous tranexamic acid in reduction of blood loss, surgical time and field visualization among patients who underwent endoscopic sinus surgery (ESS) for chronic rhinosinusitis (CRS). 

Methods:

Data Sources:  MEDLINE (PubMed), EMBASE, ScienceDirect, HERDIN, and the Cochrane Library.

Eligibility Criteria: Randomized controlled trials (RCT) between 2005-2014 that evaluated the effects of tranexamic acid or placebo in patients undergoing ESS for CRS.

Appraisal and Synthesis Methods: Articles were selected by 2 independent reviewers and methodological quality was blindly evaluated using a Jadad scale. Data were compiled in tables for analysis of outcome measures (estimated blood loss, length of surgery and intraoperative surgical field visualization).

Results: Two trials were included in the study, enrolling 128 patients. One arm of the study had been given tranexamic acid while the other arm was given placebo (saline solution). Results varied for both studies. The summary of the observed difference for blood loss had a standardized mean difference of -51.20 (CI95 [-59.44, -42.95]) showing that the blood loss in milliliters was less in the tranexamic group compared to saline solution. The summary of the observed difference in surgical time had a standardized mean difference of -19.32 (CI95 [-24.21, -14.43]) showing that the surgical time in minutes was shorter in the tranexamic group compared to saline solution. The secondary outcome on surgical field visualization was not pooled together because the studies used different measurement scales.

Limitations:  The most important weaknesses of the 2 included studies were the differences in dose of tranexamic acid, scales of measurement of field visibility and age groups of the patients. 

Conclusion: Tranexamic acid reduced blood loss and shortened surgical time after ESS among patients with CRS. However, the additional benefit of tranexamic acid for better field visualization was not clear. Adverse effects were not considered in this study, however results support the use of intravenous tranexamic acid intraoperatively as an option for ESS with blood loss as a concern. Further randomized clinical trials and an update on the systematic review will strengthen the evidence on the effectivity of tranexamic acid for ESS.

Keywords: tranexamic acid, endoscopic sinus surgery, bleeding time
Accuracy of Fine Needle Aspiration Biopsy in Diagnosing Parotid Gland Malignancy
Authors: Santiago Kathleen Joy B. , Roldan Rodante A. , Castañeda Samantha S.
Published: April 2019

Objective: To determine the sensitivity, specificity, positive predictive value, negative predictive value and overall accuracy of FNAB in detecting parotid malignancies in our institution.

Methods:

Design:           Retrospective Chart Review

Setting:           Tertiary Government Hospital

Participants: Postoperative records of seventy six (76) patients with tumors of the parotid gland preoperatively diagnosed by FNAB.

Results: The sensitivity of FNAB was 46%. The specificity and positive predictive value were both 100% and negative predictive value was 90%. Overall accuracy in diagnosing malignant parotid tumor was 91%.

Conclusion: FNAB in this institution is a poor predictor of malignancy, having a sensitivity rate of only 46%. While this may serve as a basis for not recommending pre-operative FNAB for patients with parotid tumors in the interim, other factors should also be considered, including concerns with the actual performance and interpretion of FNAB in our institution.

Keywords: Parotid neoplasm, Cancer of the parotid, fine needle aspiration biopsy, sensitivity, specificity, accuracy
Oral Propranolol Therapy for Benign Capillary Hemangiomas in a Series of Adult and Pediatric Patients
Authors: Dimaguila Gerardo Aniano C. , Samson Emmanuel S.
Published: April 2019

Objective: To describe outcomes of oral propranolol therapy in a series of adult and pediatric patients diagnosed with benign capillary hemangioma of the head and neck.

Methods:

            Design:           Prospective Case Series

            Setting:           Tertiary Government Hospital

Participants: Ten (10) patients representing all patients clinically diagnosed with benign capillary hemangioma of the head and neck, enrolled in the study from 2012 to 2015.

Results: Two (2) adults and eight (8) children were enrolled in the study. Although a decrease in lesion size was observed in half of the participants starting at three months, only one (1) attained complete resolution of the lesion-- a 12-year-old girl with hemangioma of the right parotid gland that attained clinical resolution of symptoms after four months of treatment. The remaining nine out of ten (9/10) participants did not attain complete clinical resolution; but there was a decrease in lesion size in four (4) of these participants. For the remaining five (5) participants, there was neither a decrease nor an increase in lesion size. Altogether, of the two adult participants, only one responded to therapy, while only 4 out of 8 pediatric participants responded to therapy. There were no noticeable differences between adult and pediatric patients in terms of resolution and plateau. Aside from mild bradycardia expected with propranolol, no adverse reactions were observed during the course of treatment.

Conclusion: Although half of our participants responded to oral propranolol therapy, whether these observations may be attributable to oral propranolol alone cannot be concluded.

Keywords: hemangioma, capillary; hemangioma; propranolol administration, oral; propranolol
Basal Cell Carcinoma, Odontogenic Cysts, Brain and Skeletal Abnormalities (Gorlin Goltz) Syndrome in a 46-Year-Old Woman
Authors: Magbuhat Diane Clarice D. , Matsuo Jeannette Marie S. , De la Cruz Rhodieleen Anne R.
Published: April 2019

Objective: To present the case of a 46-year-old woman with basal cell carcinoma, odontogenic cysts, brain anomalies and skeletal abnormalities.

Method:

            Design:           Case Report

            Setting:           Tertiary National University Hospital

            Patient:           One

Results: A 46-year-old woman consulted for a non-healing, necrotic left orbital ulcer that started as a skin-colored, papilla-like lesion on the upper eyelid. There were also hyperpigmented lesions with ill-defined borders over both paranasal areas. Tissue biopsies revealed basal cell carcinoma. Radiologic imaging showed cystic lesions in the mandible, straightening of cervical vertebrae and calcifications of the falx cerebri, tentorium cerebelli, pineal gland and choroid plexus. Based on established major and minor clinical and radiologic criteria, we arrived at a diagnosis of Gorlin Goltz Syndrome or Nevoid Basal Cell Carcinoma Syndrome (NBCCS). She underwent wide excision of the left orbital mass with exenteration, excision of left and right paranasal masses, left total parotidectomy with facial nerve preservation, enucleation of mandibular cyst, and cervicofacial reconstruction with skin grafts of the left orbital area and ala.

Conclusion: NBCCS is a rare autosomal dominant disorder with a high tendency for neoplasms and developmental anomalies. Diagnosis can easily be missed if the physician is unaware of its classic but bizarre presentation. Early recognition and prompt specialist referral is very important in order to prevent complications and provide better prognosis. Patients should be reminded of the importance of follow-up as other presentations of the syndrome may manifest later in life, and family genetic screening and counseling should be undertaken.

Keywords: Gorlin Goltz Syndrome; Nevoid Basal Cell Carcinoma Syndrome; odontogenic keratocyst
Unilateral Tonsillar Hypertrophy in a 4-Year-Old Girl with Focal Dermal Hypoplasia (Goltz Syndrome)
Authors: Ong John Emmanuel L. , Cruz Emmanuel Tadeus S. , Barrientos Clydine Maria Antonette G.
Published: April 2019

Objective: To report a case of unilateral tonsillar hypertrophy resulting in severe Obstructive Sleep Apnea in a 4-year-old girl with focal dermal hypoplasia (FDH, Goltz or Goltz-Gorlin) Syndrome.

Methods:

Design:           Case Report

Setting:           Tertiary Teaching Hospital

            Subject:          One

Results: A 4-year-old girl with Goltz Syndrome (classical features of cutaneous and osteopathic disorders since birth) and unilateral tonsillar hypertrophy manifested with snoring and apneic episodes at two years of age. Polysomnography revealed severe Obstructive Sleep Apnea, and Arterial Blood Gases revealed metabolic acidosis with hypoxemia. A tonsillectomy and adenoidectomy improved breathing, appetite and sleep with resolution of snoring and apneic spells and final tonsil histopathology revealed lymphoepithelial polyp.

Conclusion: A 4-year-old child with Goltz syndrome, who developed severe obstructive sleep apnea due to tonsillar hypertrophy was presented.  Otolaryngologists should be aware of this syndrome, which may manifest with oral and mucosal lesions.   Although rare, Goltz syndrome may be considered in the differential diagnosis of tonsillar hypertrophy especially in the presence of the inherent clinical features. Physicians should educate patients and address the co-morbidities associated with it through individualized treatment.  

 

Keywords: Focal Dermal Hypoplasia, Unilateral Tonsillar Hypertrophy, Goltz Syndrome, Goltz-Gorlin Syndrome
Late-onset Anterolateral Thigh Free Flap Failure in Buccal Carcinoma Reconstruction
Authors: Mendoza Daniel Jose C. , Nieves Cristina S. , Castañeda Samantha S.
Published: April 2019

Objective: To report a case of late-onset anterolateral thigh free flap failure in reconstruction of a defect from excision of buccal carcinoma.

Methods:

Design:           Case Report

Setting:           Tertiary Government Hospital

Participant:   One

Results: Complete flap failure of the anterolateral thigh free flap used for reconstructing the defect from a buccal cancer excision was documented on the 29th post-operative day.

Conclusion:  Late-onset flap failure is mainly non-vascular in etiology. However, flap failure is more likely multifactorial. Frequent follow-up after hospital discharge is recommended to monitor flap viability.

Keywords: free flap, anterolateral thigh flap, flap failure, microvascular surgery, head and neck reconstruction
Prevalence of Supraorbital Ethmoid Air Cells among Filipinos
Authors: Carlos Avian Loren C. , Gelera January E.
Published: April 2019

Objective : This study aims to determine the prevalence of supraorbital ethmoidal cells (SOEC) among Filipinos in a single tertiary government institution. 

Methods:

 

Study Design:            Retrospective review of CT scan images

Setting:                       Single Tertiary Institution

Patients:                     123 patients aged 13-years-old and above

 

Results: A total of 474 CT scans (60 PNS and 414 Craniofacial) performed during the study period were considered, with 55 excluded for age < 13, and 296 excluded for craniofacial fractures. None had congenital craniofacial deformities.  Eighty-five of 123 CT scans (69.11%) or 147 of 246 sides (59.76%) demonstrated supraorbital ethmoidal cells. There were 62 (72.94%) males and 23 (27.06%) females, ages ranging from 13 to 83 (mean age between male and female was 39.53 and 43.57). The scans showed 62 (50.41%) patients with bilateral and 23 (18.70%) with unilateral SOEC. Twenty-two (25.9%) patients were identified with chronic rhinosinusitis and two of whom were considered to have maxillary sinus mass. Two out of 5 patients with SOEC presented with aplastic/hypoplastic frontal sinus.

Conclusion: Our study suggests that Filipinos may have a higher prevalence rate of SOEC than their Chinese, Japanese and Korean counterparts and bilateral SOEC are more predominant than unilateral SOEC.

 

Keywords: supraorbital ethmoid cell, anterior ethmoid artery, paranasal CT scan, craniofacial CT scan, frontal sinus surgery
ENHANCING BUSINESS PERFORMANCE OF SAHID MONTANA HOTEL MALANG IN TOURISM PROGRAM
Authors: Larasati Novia , Shinta Gusti Ayu , Mahendra Dennis , Sanchez Vanessa , Denisa Pinandita , Yulza Della Fany , Almutari Naser B M AA
Published: April 2019

Sahid montana is a 5 star hotel located in Malang. The hotel has a herritage-themed design, which makes Sahid hotel has its own advantages from other hotels. Sahid Montana wants his hotel to be known internationally. The idea for Sahid Montana if want go international are to create an attractive package for the tourists so will be interested and create activities such as learning traditional dance and learning to make batik. Sahid Montana does not have a target country because Sahid Montana wants all customers from all the countries can stay at Sahid Hotel. If want to succeed until the international level it will require some strategies in doing promotions such as creating websites and join some events in Festival Beautiful Indonesia in abroad.
Psychometric Evaluation of Newly Developed Self-Assessment of Entrepreneurial Competencies
Authors: Riyanti Benedicta Prihatin Dwi , Suwartono Christiany
Published: April 2019

Entering the ASEAN economic community today, Indonesia activelyencourages the number of entrepreneurs. One of the primary resourcesis from the graduates of the vocational high school. The school needsa strategic way to evaluate the improvement of its entrepreneurship curriculum. Therefore, we designed a self-assessment of entrepreneurial competencies. The authors developed an assessment consists of various soft skill and hard skill competencies. Participants were asked to assess own abilities, according to the statements provided. The participants were 258 graduated vocational students from Yogyakarta and Jakarta. From 137 preliminary items, we took 24 best items. Results showed that three-factor model provided an adequate fit for the data. Business management capabilities, strategic thinking skills in managing the business, and the ability to see the opportunities emerged as first-order factors. The reliability estimation with the internal consistency method involved the Cronbach’s alpha for all subtests showed excellent results. Future studies are still needed to test the predictive power of the test tool to the success of graduateswho becomean entrepreneur.
FACTORS AFFECTING CONSUMERS IN USING SERVICES J&T EXPRESS (CASE STUDY ON J&T EXPRESS BRANCH MARGONDA DEPOK)
Authors: Saputri Helen Aldila , Nugroho Widyo
Published: April 2019

J&T Express is one of the companies engaged in the provision of logistics services in the form of delivery of documents and goods that can compete with senior companies. One marketing strategy undertaken by a J&T Express company is to use a Brand Ambassador as part of advertising, where other similar companies do not use brand ambassadors as a means of promotion. Maintaining the quality of service also becomes one part of the strategy that companies do in the face of competition. The decision of prospective users of logistic services also has another factor as an indicator of the selection of logistics service providers, is price. In this study discussed three dependent variables that affect consumer decisions in using J&T express services consisting of Brand Ambassador, Service Quality, and Price. This research will be carried out by spreading 200 questionnaires to consumers who use the services of J&T Express Branch Margonda Depok. Technique done using technique of Multiple Linear Regression, Analysis using SPSS analysis tool 23. The result of research proves that three variables namely Brand Ambassador, Service Quality, and Price partially influence to consumer decision in using services of J&T Express Branch Margonda Depok. And simultaneously there is a positive influence between independent variables namely Brand Ambassador variable, Service Quality and Price to the dependent variable that is consumer decision. It is seen that the relationship between Brand Ambassador variable, Service quality, and Price on Consumer Decision is quite strong, that is R = 0,634 or equal to 63,4%
Implementation of Social Security Protection for Workers at the Village Level (Research Study at Langsa City-Aceh)
Authors: Bustami Bustami , Fitriani Rini , Krisna Liza Agnesta
Published: April 2019

This research aims to analyze the implementation of social security protection for works at the village level through Social Security Administrator (BPJS) at Langsa city, Aceh. The type of this research is juridical Empirical, approach methodology that used in this research is sociological juridical which get the truth in empirical way by reviewing directly to the people about the implementation of social security protection for workers at the village level. In fact, the implementation of social security protection for workers at the village level has not ran optimally, even though the dues for the social security protection is not from the workers’ salary, but funded by the government, there are 2 (two) obstacles that faced which is internally each village’s headman wisdom, and the workers’ incomprehension to the rights of the social security protection for workers they have, meanwhile externally is lack of socialization from the Social Security Administrator (BPJS) so that there is information misunderstanding that received by the village’s headman, and the election for the new village’s headman is still on process. The effort to increase the socialization and give the understanding in detail to the village’s headman about the purpose and the use of social security protection for workers.
Can emerging markets be a source of global troubles again?
Authors: Dabrowski Marek
Published: April 2019

After two turbulent decades (1980s and 1990s) when emerging-market economies were frequent victims of financial crises, in the first two decades of the 21st century their macroeconomic performance improved. Nevertheless, there were three crisis episodes that hit some of these countries: (i) the spill-over effects of the global financial crisis in 2008–2009; (ii) the consequences of the decline in commodity prices in 2014–2016 for their exporters; (iii) the turbulence in Argentina and Turkey in 2018. Currency crises in Argentina and Turkey in 2018 underlined again the key role of prudent domestic policies. Early policy correction can help to prevent a crisis and avoid its economic, social and political costs. If crisis cannot be avoided, the comprehensive anti-crisis package, including up-front monetary and fiscal adjustment, should be adopted as quickly as possible to arrest market panic and reverse negative expectations.
Latent Fingerprint Identification Using Deep Learning Method
Authors: P Shree Nandhini.
Published: April 2019

Digital fingerprint is one of the most consistent modalities in up to date biometrics and hence has been broadly studied and deploy in real applications. The accuracy of one Automatic Fingerprint Identification System (AFIS) largely depends on the quality of fingerprint samples, as it has an important impact on the degradation of the matching (comparison) error rates. This thesis generally focuses on the evaluation of biometric quality metrics and Fingerprint Quality Assessment (FQA), particularly in estimating the quality of gray-level latent fingerprint images or represented by minutiae set. By making a refined review of both biometric systems and relevant evaluation techniques, this contribute by the definition of a new evaluation or validation outline for estimating the performance of biometric quality metrics. It is defined to check the quality of latent fingerprint images by statistically measured parameters. In this work, an automatic Region-Of-Interest (ROI)-based latent fingerprint quality assessment technique is proposed by using deep learning. The first stage in our model uses deep learning, namely Region Convolutional Neural Network (R-CNN) to segment a latent fingerprint. In the second stage, feature vectors computed from the segmented latent fingerprint are used as input to a multi-class perceptron that predicts the value of the fingerprint. This proposed approach eliminates the need for manual ROI and feature markup by dormant examiners. Finally, experimental results on NIST SD27 show the effectiveness of our technique in latent fingerprint quality prediction
Elaboración de una bebida funcional de borojó (Borojoa patinoi) enriquecida con Lactobacillus casei, empleando como sustrato el suero proveniente de la elaboración de queso fresco de la Industria Lechera Carchi
Authors: Burbano P. Marco , Amador S. Carlos
Published: April 2019

La presente investigación se fundamentó en la formulación de una bebida láctea funcional, elaborada a base del suero de leche proveniente de la elaboración de quesos frescos de la Industria Lechera Carchi de la ciudad de Tulcán, que tuvo como ingrediente sabori- zante la pulpa de borojó (Borojoa patinoi) y como agente probiótico a Lactobacillus casei. En cuanto a la bebida formulada, se partió del análisis cuatro tratamientos T1 (tratamiento con 2,5% de saborizante), T2 (tratamiento con 5% de saborizante), T3 (tratamiento con  7,5% de saborizante) y T4 (tratamiento con 10% de saborizante), a los mismos que se evaluó física, química, bromatológica y sensorialmente, con el propósito de establecer sus parámetros de calidad y seleccionar el mejor tratamiento. Los resultados en muchos de los casos no mostraron diferencias estadísticas significativas desde el punto de vista nutricional, pero si se evidenció un nivel superior por parte de T4 con respecto a T1; T2 y T3 en la mayor parte de análisis presentaron resultados muy parecidos. Desde el punto de vista microbiológico únicamente T1 presentó inconvenientes; específicamente en cuanto al límite máximo establecido por la normativa INEN en lo que respecta a Salmonella spp. Finalmente el análisis organoléptico llevado a cabo por un grupo de 34 catadores arrojó como resultado que los mejores tratamientos fueron T3 y T4, concluyéndose que la mayor concentración del saborizante aportó positivamente a la mayoría de las características sensoriales del producto.
Incidencia del uso de ácido Acético y ácido Láctico en la vida útil del filete de trucha Arcoíris (Oncorhynchus mykiss)
Authors: Delgado Ramos Andrea Verónica , Mosquera Araújo Corina
Published: April 2019

La presente investigación se fundamentó en el análisis de incidencia del ácido láctico y acético en la vida útil del filete de trucha {Oncorhynchus mykiss). Partimos tratando las unidades experimentales {200 - 300 g de filete) en inmersiones de las soluciones de los ácidos en estudio al 0,5% y 1% por 5 y 10 min. alma- cenados a 4 QC; cada tres días se evaluó Nitrógeno Básico Volátil {NBV) en mg/100g, Mesófilos Aerobios en UFC/g y sensorialmente el color, textura y olor, como indicadores de calidad en la vida útil del filete y con el fin de determinar el mejor tratamiento. Los resultados no mostraron diferencias significativas para NBV y Mesófilos Aerobios, estadísticamente todos los tratamientos tienen igual comportamiento entre sí y resultan estadísticamente diferentes con respecto al testigo. El análisis organoléptico indica que todos los tratamientos conservan las características hasta el noveno día, mostrando que el día 12 que ninguno se encuentra apto para el consumo humano, resultando concomitante a los análisis de NBV y mesófilos aerobios. El testigo tiene un tiempo de descomposición acelerado y fue rechazado al noveno día.
Extracción de pigmentos naturales a partir de cerote (Hesperomeles het- erophylla), motilón (Hyeronima macrocarpa), mortiño (Vaccinium loribundum) y su aplicación en la elaboración de yogurt de mora (rubus glaucus benth)
Authors: Mina Ortega Jorge Iván , Torres Mayanquer Freddy Giovanny
Published: April 2019

Ecuador posee una amplia gama de frutos con potencialidades tintoreas, de los cuales existen muy pocas investigaciones que nos permita establecer el potencial de ellas como alimento con propiedades funcio- nales y el desarrollo de productos con valor agregado que puedan ser usados como colorantes naturales para la producción de alimentos. El objetivo de este trabajo es extraer los pigmentos naturales a partir del mortiño, motilón y cerote e iden- tificar cuál de los extractos presenta mejores características para ser empleado como aditivo colorante. En la segunda fase los extractos acuosos de los frutos señalados se liofilizaron y fueron evaporados en un rotovaporador, los concentrados obtenidos se adicionaron en concentraciones de 0.5, 1.0, 1.5 y 2 g/100 g de yogur natural comercial, valorando su estabilidad durante 30 días de almacenamiento. Al yogur adi- cionado se le determinó: grados Brix y pH. Además, se evaluó el nivel de agrado del yogur adicionado con una prueba de preferencia por color. Por medio del análisis sensorial que se realizó a los yogures adicionados los pigmentos de mortiño, motilón y cerote se determinó que presentan el color y la pureza más cercanos a los del yogur comercial sabor mora. Con estos resultados se comprobó que las frutas estudiadas son una fuente promisoria de pigmentos na- turales, y es posible su uso para colorear alimentos de acidez media como el yogur, siendo las muestras más preferidas el motilón y cerote
Gestión del conocimiento dentro de una empresa constructora vial
Authors: Valenzuela Schaw Karen Nicole , Arellano Ramos Enzo Alejandro
Published: April 2019

El desarrollo de un sistema de gestión del conocimiento al interior de una organización, se tra- duce en recopilar, almacenar y transferir aquellos conocimientos que le permiten a una empresa generar productos o servicios de alto nivel de calidad y satisfacción, tanto para traba}adores como para clientes. Este estudio se ha llevado a cabo en Ingeniería y Construcciones Santa Fe S.A, empresa que se dedica específicamente a construir obras viales. Para las empresas lo más importante además del activo tangible, debiera ser el activo intangible, o sea, el capital humano y por lo cual es de gran importancia aumentar dicho capital, para ello se debe gestionar el con- ocimiento y tener como resultado final el aumento del valor de la empresa. Una vez analizada la organización, se identifican las falencias y se entregan recomendaciones que la empresa puede tomar en consideración para me}orar y ser competitiva en el mercado en que está involucrada.
La educación financiera y el sobreendeudamiento de los comerciantes de la ciudad de Tulcán
Authors: Carvajal Pérez Luis Alfredo , Arcos Ponce Georgina Guadalupe , Gutierrez Villarreal Milena Del Rocio
Published: April 2019

Esta investigación se enfoca en el estudio del sobreendeudamiento de los comerciantes de la ciudad de Tulcán generado por su escasa educación inanciera, es decir que si el comerciante no equilibra sus conocimientos de inanzas con sus emociones puede tomar decisiones equivo- cadas que le ubiquen en un alto nivel de riesgo de endeudamiento y a su vez desencadena otros problemas de carácter social, que afectan la economía e incluso desintegración familiar. Para obtener la información se realizó un estudio de campo aplicando entrevistas a Gerentes de las entidades inancieras y encuestas a los comerciantes de Tulcán que permitió relacionar las variables y determinar los resultados de la investigación. Esto se complementó con el uso de información secundaria de datos estadísticos de la Superintendencia de Bancos, Superinten- dencia de Economía Popular y Solidaria, y Banco Central del Ecuador como soporte del análisis. La investigación muestra que existen problemas de sobreendeudamiento ocasionados porque los comerciantes no han recibido capacitación especíica en Finanzas, no saben determinar su capacidad de pago, sus ganancias son reducidas, existe sobre oferta del sistema cooperativo y bancario, la gente no planiica adecuadamente el destino de los recursos, ni la forma de pago, asumiendo altos riesgos por invertir en algo que no está debidamente analizado, no equilibran lo intelectual con lo emocional en sus decisiones inancieras.
Desarrollo ágil de aplicaciones empresariales nativas de Android que consumen servicios web soap en la nube
Authors: Trejo España Diego Javier
Published: April 2019

El creciente uso de dispositivos móviles inteligentes, ha traído además una demanda cada vez más elevada de aplicaciones móviles. El mercado actual lo lideran los dispositivos con Sistema Operativo Android, por tanto es necesario satisfacer de una manera ágil la demanda de aplica- ciones Android. Al respecto, existen especificaciones generales que deben cumplir las aplica- ciones móviles, así como una arquitectura que incluye el consumo de Web Services en formato XML SOAP que encapsulan Bases de Datos empresariales. Los IDE's de desarrollo para Android más prometedores no incluyen librerías con soporte total para el consumo de Web Services, por lo que hay que evaluar librerías de terceros o incluso crear nuestras propias librerías para acelerar el desarrollo de aplicacines Android con acceso a Web Services Empresariales. En el presente traba}o se plantea una solución que reduce sustancialmente el tiempo de desarrollo del tipo de aplicaciones móviles nativas para Android.
Condicionamiento de la gestión cultural
Authors: Escudero Sánchez Carlos Leonel
Published: April 2019

El condicionamiento de la gestión cultural por las relaciones sociales se despliega a través de infiuencias en las que la cultura es mediada y mediatizadora de procesos sociales concretos con destaque, por la fuerza de su vínculo, para la economía y la política. Idea que evidencia que el peso concedido a lo económico en la gestión cultural muestra una perspectiva inscrita en la óp- tica neoliberal. Junto a esta mediación está la política, pues no existe gestión que no responda a los centros de poder en su expresión cotidiana y reticular. la enunciación e implementación for- malizada de las políticas culturales coincide con el surgimiento y devenir de la gestión cultural. Los condicionamientos de la gestión cultural constituyen mediaciones mutuas en tanto lo económi- co, lo político y lo cultural se interpenetran. Tal interrelación es observable en cada uno de los sectores sociales en que se produce una práctica de gestión cultural. De ahí la necesidad de asumir a la política cultural como fundamento que transversaliza la gestión en cada uno de estos sectores para su estudio.
El Caballo que regresaba de las guerras
Authors: Reino Garcés Pedro Arturo
Published: April 2019

Tienes que prometerme que también dejarás escrita para otros esta historia. He viajado lo suficiente como para alargar mi vida, y he dormido tan poco para soñar despierto. Lo que vas a oír es tan cierto que parece haber sido dicho por alguien que solo lo ha oído: La gente de Pasto, de Guaitarilla, de Berruecos, de Pupiales; de las gargantas del Juanambú donde estornudan las sombras y se desbarrancan enigmas al Patía; las de Tulcán y hasta las de San Ga- briel y Huaca, son la que más recuerdan al caballo. Pasaba cabalgado, cada cierto tiempo, con tan solo una camisa herida y desflecada. Volaba sobre los abismos desbarrancando a destiempo las piedras amontonadas por Agualongo. Cruzaba pisoteando ese ajedrez de lomeríos verdes de la melancolía. Eran tiempos del frío sin fronteras, de peones que lidiaban con caballos que relinch- aban sus porfías manoteando la resignación de los potreros. Las vacas rumiaban antiguas indif- erencias mirando cómo los vecinos de los caseríos les alambraban los linderos. Se agachaban a resoplar un aire ajeno a las obsesiones de los reclutadores, porque llegaban pesquisas milicianas que se habían puesto a practicar el calorcito de las guerras.
A cluster-controlled clinical trial of two prophylactic silicone sacral dressings to prevent sacral pressure injuries in critically ill patients
Authors: Stankiewicz Monica , Gordon Jodie , Dulhunty Joel , Brown Wendy , Pollock Hamish , Barker-Gregory Nicola
Published: April 2019

Objective Patients in the intensive care unit (ICU) have increased risk of pressure injury (PI) development due to critical illness. This study compared two silicone dressings used in the Australian ICU setting for sacral PI prevention.
Design A cluster-controlled clinical trial of two sacral dressings with four alternating periods of three months' duration.
Setting A 10-bed general adult ICU in outer-metropolitan Brisbane, Queensland, Australia.
Participants Adult participants who did not have a sacral PI present on ICU admission and were able to have a dressing applied for more than 24 hours without repeated dislodgement or soiling in a 24-hour period (>3 times).
Interventions Dressing 1 (Allevyn Gentle Border Sacrum™, Smith & Nephew) and Dressing 2 (Mepilex Border Sacrum™, Mölnlycke).
Main outcomes measures The primary outcome was the incidence of a new sacral PI (stage 1 or greater) per 100 dressing days in the ICU. Secondary outcomes were the mean number of dressings per patient, the cost difference of dressings to prevent a sacral PI and product integrity.
Results There was no difference in the incidence of a new sacral PI (0.44 per 100 dressing days for both products, p = 1.00), the mean number of dressings per patient per day (0.50 for both products, p = 0.51) and product integrity (85% for Dressing 1 and 84% for Dressing 2, p = 0.69). There was a dressing cost difference per patient (A$10.29 for Dressing 1 and A$28.84 for Dressing 2, p < 0.001).
Conclusions Similar efficacy, product use and product integrity, but differential cost, were observed for two prophylactic silicone dressings in the prevention of PIs in the intensive care patient. We recommend the use of sacral prophylactic dressings for at-risk patients, with the choice of product based on ease of application, clinician preference and overall cost-effectiveness of the dressing.
Compression bandaging: Identification of factors contributing to non-concordance
Authors: Boxall Sharon , Carville Keryln , Leslie Gavin , Jansen Shirley
Published: April 2019

Aims To elucidate reasons for non-concordance with compression bandaging, subject the identified reasons to thematic analysis and use the resultant themes as the basis for the development of a screening tool to identify those patients at risk of non-concordance with compression bandaging.
Method A literature search was undertaken using the terms ‘concordance’, ‘compression bandaging’ and ‘venous leg ulcer’. Articles were included if they discussed reasons for non-concordance with compression bandaging. Forty-one articles were identified which met inclusion criteria. The full texts were read and the reasons for non-concordance tabulated. These were then subjected to thematic analysis.
Results Six themes emerged. These were termed knowledge deficit; resource deficit; psychosocial issues; pain/discomfort; physical limitations; and wound management. These themes were used to develop a screening tool to identify patients who exhibit barriers to concordance with compression bandaging.
Discussion Compression bandaging is the recommended treatment for venous leg ulceration1-3. However, the degree of concordance with compression bandaging therapy remains at sub-optimal levels4,5. Consequently patients experience protracted ulceration. The development of a risk screening tool for non-concordance will permit targeted intervention to address barriers to concordance before the patient has a poor experience of compression therapy.
Frequency of the most common CYP3A5 polymorphisms in the healthy population of the Republic of Macedonia
Authors: Jakovski Krume , Kapedanovska Nestorovska Aleksandra , Labacevski Nikola , J. Dimovski Aleksandar
Published: April 2019

The genetic polymorphism affecting the CYP3A5 enzyme is responsible for inter-individual and interethnic variability in the metabolism of CYP3A5 substrates. The aim of this study was to analyze the distribution of the most common CYP3A5*3 allelic variants in the healthy population of R. Macedonia and to investigate if the allelic frequency falls within the assumed range for European Caucasians. The total of 174 healthy volunteers from the general population were included. The genotyping of the CYP3A5*3 variant alleles, *3A (rs15524) and *3E (rs28365095), was performed with Real-Time PCR based on the allelic discrimination method using a TaqMan SNP genotyping assay according to the manufacturer’s instructions. The CYP3A5*3 allele is abundantly present displaying an allelic frequency of 0.922. We estimate that 0.82 of the Macedonian population are homozygotes for the variant and do not have a CYP3A5 enzymatic activity. Our study demonstrated a high prevalence of CYP3A5*3 allele in the Macedonian population. The distribution of CYP3A5 alleles was similar to that found in other European Caucasians. As the goals of personalized medicine are beginning to be realized, this provides basic
information on the CYP3A5 allele frequency for the future pharmacogenetic research in R. Macedonia.
Natural antioxidants in cancer prevention
Authors: Arsova-Sarafinovska Zorica , J. Dimovski Aleksandar
Published: April 2019

It is well known that oxidative stress is an inevitable event in aerobic life. When our cells use oxygen to create energy, a variety of reactive oxygen (ROS) and nitrogen species (RNS) are generated. These species could attack DNA directly and form mutagenic lesions afterwards. According to the oxidative stress hypothesis of aging, the oxidative damage to critical molecules accumulates over the life period and could ultimately impair the body’s function. Moreover, severe oxidative stress causes mutations of tumor suppressor genes, known as one of the initial events in carcinogenesis. Furthermore, it could also play a crucial role in the promotion of the multi-step carcinogenesis.
On the other hand, the human body possesses a number of mechanisms that counteract oxidative stress by producing antioxidants in situ, or externally supplied them through foods and/or supplements. Indeed, a considerable amount of laboratory evidence from chemical, cell culture, and animal studies indicates that antioxidants may slow down or possibly prevent the cancer development. Yet, the information from
recent cohort, case-control and/or ecological studies is less clear. Therefore, the objectives of this review are to compile a compendium of studies, and to identify effective and promising natural antioxidant interventions.
Psychological distinguished characteristics of legal education in the context of reformation of the legal system of Ukraine
Authors: Boiko-Buzyl Yuliia , Salii Iryna
Published: April 2019

The article will be interesting for specialists in psychology and law, scientific and scientific-pedagogical staff, who participate in educational process in sphere of legal education of individual. This article describes (justifies) the insufficiency of illustration, in previously written scientific projects, of the basics of legal education on current stage of Ukrainian reforms, in which main psychological aspects would be taken into account. These aspects are based on creation of individual’s legal culture with prevalence of universal human values. This article shows that modern life realities demand determination of place and role for legal education, taking into account psychological aspects, in the context of reformation of the Legal System, its aim and tasks, review and improvement of forms and methods. Scientific task on justification of main psychological principles of legal education on current stage of our state development was formulated. The main idea is creation of legal culture of individual in whom universal human values prevail. It is defined, that legal education mast be based on: deeply rooted folk traditions of humanism;  folk pedagogics; best samples of world culture (which are the most important factors of personality formation); ideological principles of universal human  values and ideas of creation of constitutional stat; ideological basis (The Constitution of Ukraine); pluralism; fusion of possibilities of folk pedagogics; the best moral and ethical traditions; moral laws of the Bible; the best samples of achievements of world civilization; culture; idea of philosophical and religious social consciousness; interconnection and coherence of legal education with modern state-building processes in Ukraine. Pedagogues, psychologists and lawyers, who are involved in work on problems of legal education, should concentrate their efforts on possibilities of psychology and law to ensure behavior, which would guaranty progressive and irreversible development of society.
Igor Kon: «You Can’t Hide Anything From History» From Email Correspondence With I.S. Kon. Part I. 2005-2006
Authors: Doktorov Boris
Published: April 2019

This article is an introduction to the description and analysis of the electronic correspondence of the author with I.S. Kon, held in 2005-2011. Kon belongs to a narrow group of sociologists who stood at the origins of Soviet sociology. For many years, Kon has successfully worked in different areas of sociology, at the same time he is a recognized expert in the history of Russian and Western sociology. All this: 1) makes Kon a unique expert in the field of studying the entire period of development of Russian sociology, and 2) determines the historical, sociological and methodological value of his letters. Let us pay attention to the fact that the study of the correspondence of sociologists is a poorly studied topic, but there is a tendency to increase attention to it. The total number of letters is about 200. The texts of 39 letters for 2005-2006 are given. The history of correspondence and its content is briefly considered.
Political and socio-economic development of modern Russia: environmental obstacles and risks
Authors: Tsepilova Olga
Published: April 2019

The article deals with environmental obstructions and limitations for a dynamic political and socioeconomic development of modern Russia. Environmental problems accumulated in the past decades, including problems that appeared in the "Soviet" period of the country's development, together with growing new environmental risks, become a serious obstacle to the progressive development of the country. Contemporary Russian manufacturing practices continue to use extensively anti-environmental obsolete technologies, which lead to increasing degradation of the natural environment and an increase in negative trends in the health of the population. The absence or limited use of remediation activities in extractive industries has led to the natural degradation of a number of territories in the country. Unfavorable socio-demographic characteristics of the development for modern Russia caused by the environmental factors hinder innovative development in all spheres of society in the present period; moreover, their increasing impact will be an obstacle to socio-economic development in the future. Additionally the article discusses long-term negative trends in the development of environmental policy and weakening of the ecological spectrum of civil society.