bluuebunny/crossref_metadata_2025 huggingface dataset:
Essential Oil Chemical Characterization and Antibacterial Activities of Lepidium sativum Seed
Authors: Nigussie Gashaw , Desta Dinkayehu , Ashenafi Sintayehu , Werede Yemane
Published: April 2021

Lepidium sativum plants are available abundantly in all part of Ethiopia and traditionally used for the treatment of various ailments. The work done on essential oil chemical characterization and biological activity of this plant are still insufficient reports in Ethiopia. Therefore the aim of the present study was to carry out essential oil chemical characterization and antibacterial activities of the seeds extracts and oils of L. sativum obtained from the local area Kersu Kebele, Goma Wereda, Jimma zone. The study was conducted by extraction of the seeds with organic solvents n-hexane, dichloromethane, ethyl acetate and methanol. The study performed on extraction of essential oil of the seed through hydrodistillation and investigation of phytochemical constituents of each solvent extract. The n-hexane extract (oil) and the essential oil of the seed extract were analyzed with GC-MS and 11 components were obtained from each types of oil. 7, 10, 13-hexadecatrienoic acid (64.42%) and Indol (63.78%) were the major components of n-hexane extracted and essential oil of the seeds respectively. Moreover both oils were held unsaturated fatty acid, saturated fatty acid and aromatic derivative compounds. The preliminary phytochemical test revealed the presence of alkaloids, flavonoids, glycosides, phenols, saponins, anthraqunnes, and tannins. Antibacterial activities of the essential oil were implemented by disc diffusion method against one Gram positive bacterium Stphylococus aureus and three Gram negative bacteria: E.coli, Proteus mirabilis and Klibsiella pneumoniae. The inhibition zones of the samples were compared with standard drug ceftriaxone. The essential oil showed antibacterial activities on all the tested bacteria.
A Phytopharmacological Review on a Medicinal Plant: Cordia africana Lam.
Authors: Nigussie Gashaw , Ibrahim Fozia , Neway Sebsib
Published: April 2021

The use of phytoconstituents single or combined with standard medicines has been utilized in cure of different diseases. Many plants of genus Cordia comprise of trees and shrubs are widely distributed in warmer regions and have been utilized in management of various diseases. Cordia africana Lam. (family- Boraginaceae) is a small to medium-sized evergreen tree, 4 to 15 (30) m high, heavily branched with a spreading, umbrella-shaped or rounded crown. Bole typically curved or crooked. Bark grayish-brown to dark brown, smooth in young trees, but soon becoming rough and longitudinally fissured with age; young branch lets with sparse long. Uses of C. africana: firewood, timber (furniture, beehives, boxes, mortars, church, drums), food (fruit), medicine (bark, roots), fodder (leaves), bee forage, mulch, soil conservation, ornamental, shade. Various phytoconstituents like flavonoids, alkaloids, tannins, terpenoids, saponins, steroids, anthraquinones, carbohydrates and protins having different activities were screened and isolated from different parts of Cordia africana. Various important Pharmacological properties including Antioxidant, Cytotoxicity, anti-inflammatory, anthelmintic, antimicrobial, anti-nociceptive, and others have been well documented for this plant. Therefore, we have briefly reviewed the various bioactivities of Cordia africana to improve our knowledge on plant phytochemicals as therapeutic entities. The present review describes the various phytoconstituents and therapeutic potential of Cordia africana that can be followed for future research on this plant for human health benefits.
Cenários da produção docente nas licenciaturas: desafios para uma universidade pública no Sul do Brasil
Authors: Irala Valesca Brasil , Bihain Anderson Luis Jeske
Published: April 2021

Este texto objetiva mapear, em uma instituição pública do sul do Brasil, o cenário da produção docente no que tange à escolha dos veículos utilizados para socializar resultados de pesquisa, com ênfase nos professores dos cursos de Licenciatura. Caracteriza-se como um estudo descritivo de dados extraídos da produção declarada por 400 docentes em um período de três anos (2016-2018). Identificaram-se os níveis de ensino predominantemente investigados (principalmente a Educação Básica), área do conhecimento com maior produção (Ciências da Natureza) e enfoques orientativos (Metodologias de Ensino e Formação de Professores – Inicial e Continuada). Também foi constatado que a maioria dos artigos foram publicados em Língua Portuguesa, bem como o padrão quantitativo dominante por docente foi de 1 a 5 produções durante o período trienal analisado. Como prognóstico, indica-se a necessidade de serem pensados mecanismos para a formação continuada dos docentes universitários não apenas no âmbito do ensino, mas também da pesquisa.
Habilidades socioemocionais: da BNCC às salas de aula
Authors: Canettieri Marina Kurotusch , Paranahyba Jordana de Castro Balduino , Santos Soraya Vieira
Published: April 2021

O objetivo deste trabalho é identificar as bases epistemológicas e os marcos legais que sustentam a concepção de habilidades socioemocionais na Base Nacional Comum Curricular (BNCC) destinada ao Ensino Médio. A pesquisa teve caráter documental, e durante sua realização também foram analisados 3 (três) materiais de educação socioemocional de editoras brasileiras a fim de melhor compreender como o conceito trazido pela BNCC pode comparecer nas atividades escolares. Além do conteúdo explícito, também foi considerado o contexto sociopolítico que perpassa as temáticas abordadas por tais materiais. Sabendo que a BNCC busca manter a pluralidade dos currículos e a autonomia das escolas, foram apresentados benefícios e riscos da adoção do conceito aberto sobre habilidades sociais e emocionais, e suas possíveis implicações na formação dos educandos e na atuação do professor. Ademais, o trabalho teve por sustentáculo a visão da psicologia escolar crítica e a experiência de outros pesquisadores da área.
L’égalité Filles-Garçons dans l’enseignement en France: Stéréotypes de genre et programmes cachés d’éducation.
Authors: Gleyse Jacques
Published: April 2021

L’article proposé est constitué d’une revue de littérature générale et quelques études spécifiques et originales sur la question de l’égalité filles-garçons à l’école en France. Il propose une délimitation théorique des concepts de genre et de sexe au travers notamment des rôles sexués. Ensuite, après un parcours historique assez rapide, il montre comment la mixité mise en place en 1976 dans tous les établissements scolaires français, ne correspond pas du tout à l’égalité des chances ni à l’égalité de traitement des élèves filles et des élèves garçons. Les préjugés et stéréotypes de genre reste très nombreux dans les écoles de ce pays. L’article en montre de manière résumé toutes les facettes à différents niveaux de la scolarité et dans la plupart des matières mais aussi au travers de question par exemple, de la transgresion des règles scolaires et des punitions.
Pityriasis rubra pilaris post-infection due COVID-19: case report
Authors: Aguilar-Gamboa Franklin R , Cubas-Alarcon Dennis , Villegas-Chiroque Miguel , Failoc-Rojas Virgilio E
Published: April 2021

Case description: 32-month-old boy, IgG positive for SARS-CoV-2, presented to the emergency department with dermatologic lesions.
Clinical findings: Four days before admission, he presented skin eruptions with redness and pruritus on hands and feet. Generalized papular erythema was evidenced, upper extremities with diffuse erythematosquamous plaques, palmoplantar keratoderma, so he was evaluated by a dermatologist who diagnosed pityriasis rubra pilaris.
Treatment and outcome: rehydrating cream, cetirizine 0.5 mg/kg/day every two days, and prednisolone 2 mg/kg/day in the morning. He was discharged after 14 days, the patient presented clinical improvement, but the erythematous lesion persisted on the trunk and extremities. In the evaluation, after three months, the patient did not show the described lesions, evidencing an improvement and clinical resolution of the dermatological problems.
Clinical relevance: We report a patient with pityriasis rubra piloris associated with a post-infection by SARS-CoV-2 that had not been described before.
Russia-Serbia relations in the context of the activities of pro-western and pro-Russian NGOs
Authors: Mladenovic Maja
Published: April 2021

The purpose of the article is to analyze the most active western and pro-Russian non-governmental organizations working in Serbia. In the Mass Media and non-governmental sphere, the influence of Russia is rudimentary, and is often hampered by the supporters of the Euro-Atlantic ideas. The maintenance and development of a positive image in the face of information war led by Western countries against Russia, requires constant attention of Russia’s foreign policy agencies in their work with Serbian government and social structures. The active work of the government and civil society is needed for mutual promotion of cultural achievements in Russian and Serbian cultural space. The research methodology is based on the comparative approach. The author arrives at the conclusion that Western NGOs have huge financial capacities to influence the society of Serbia. They create, promote and develop their own NGOs through local contractors, whilst pro-Russian NGOs are authentic projects of pro-Russian Serbs which typically lack money and wide public action and whose projects don’t get wide information or financial support. The scientific novelty of the research consists in the fact that it is one of the first attempts to comprehensively analyze and assess the work of non-governmental organizations in modern Serbia.  
Pan-Turkism and geopolitical identity in modern Eurasia: the analysis of representations in the media
Authors: Milyukova Anna , Kovaleva Alla Vladimirovna , Valyulina Ekaterina Vladimirovna
Published: April 2021

The subject of research is quantitative and qualitative characteristics of representation of the issue of Pan-Turkism in the Mass Media. The authors study two trends of development of the Pan-Turkism ideas: on the other hand, marginalization, on the other hand - actualization, which corresponds with the periods of crises (wars, epidemics, political crises). As an alternative to separatist movements, the authors name the increase of the role of transborder cooperation in the context of Eurasian integration with the help of the Eurasian Economic Union, Shanghai Cooperation Organization, the Eurasian Economic Community, and the project of transborder regional cooperation Big Altai. The purpose of the research is to characterise the main media trends of presentation of the Pan-Turkism issue in the Mass Media. The authors demonstrate the assessment of quantitative and qualitative characteristics of media coverage of the ideas of Pan-Turkism (the dynamics of referring; the activity of media in the number of messages and mediaindex, the level, categories, genres, the most remarkable newsworthy events; the role of international social, religious, educational organizations; the position of countries, regions, public figures, government and social organizations and institutions in the media coverage of the Pan-Turkism ideas). The scientific novelty consists in the fact that the context of references to the Pan-Turkism ideas in the media, as well as the media trends in this field which are being formed, almost haven’t been studied. The main conclusions of the research are about the information agenda, formed mainly by the Russian federal Internet media, aimed at the coverage of the Pan-Turkism issues. The most active in the formation of the Pan-Turkism agenda are the Russian pro-government and pro-Armenian media. Turkey, Armenia, Syria, Azerbaijan and Nagorno-Karabakh have a negative image in the media materials in the context of Pan-Turkism. Russia, the U.S., China. Kazakhstan, Kyrgyzstan, Uzbekistan, as well as such political figures as Recep Erdoğan, Vladimir Putin, Ilham Aliyev and Nikol Vovayi Pashinyan are referred to in a positive context.   
The development of cooperation between the South Caucasus countries in the field of railway transport. The role of the international regime after the Karabakh war
Authors: Cho Yongsung
Published: April 2021

The subject of research is the mutual influence of the development of the South Caucasus countries’ transport system, and international political and economic cooperation of actors. The author emphasizes that, despite all contradictions, the “international regime” system allows the Russian Federation to participate in the work of the Baku-Tbilisi-Kars railway transport corridor. Based on the complex mutual influence theory, the author focuses on the problem of this system influencing the development of transport networks after the Nagorno-Karabakh war. The research methodology is based on the case study method which helps the author not only to analyze the activities of the parties to the conflict, but also to forecast the strategy of each of political actors of the “international regime” in the South Caucasus in the field of railway transport cooperation. The scientific novelty of the research consists in the institutional approach to the problem of conflict settlement by means of cooperation between the South Caucasian states involved in the area of interest in the field of transport logistics. Based on the research, the author concludes that for Russia, joining the Baku-Tbilisi-Kars transport corridor gives a new opportunity for mutually beneficial cooperation. Moreover, transport corridors, created by other countries in the South Caucasus, are not “competitors” within the international regime. The transformation of the movement of goods with the optimisation of routes, linking the actors, will directly or indirectly promote the economic capacity development and the interdependence of participants, which will lead to the decrease of security problems. Thus, in the long-term perspective, it can be seen that the unification of transport networks in the region will help the actors to mute conflicts and contradictions.   
Folklorismus of the works of I. I. Bashmakov in the context of “third culture” (almanac “In-Between Time”)
Authors: Usatov Konstantin Andreevich
Published: April 2021

The subject of this research is folklorismus of the works of I. I. Bashmakov, namely in almanac “In-Between Time” (“Mezhdudelye”). I. I. Bashmakov (Ivan Vanenko) is one of the representatives of mass literature of the 1830s – 1850s. The goal of this article is to demonstrate the peculiarities of using folklore plots, motifs, and images in the poetic and prose texts of the people’s writer. Bashmakov uses a thematic diversity of fairy tales, pastiche of folk songs, epic poems, and anectodes. His texts also feature traditional elements of the combination of peasant and urban culture (“third culture”). Analysis is conducted on the almanac “In-Between Time” (“Mezhdudelye”) by I. I. Bashmakov, using the cultural-historical and historical-literary methods. The novelty lies in consideration of folklorismus of the works of I. I. Bashmakov in the context of “third culture”. The works contained in the almanac “In-Between Time” (“Mezhdudelye”) are introduced into the scientific discourse. Folklorismus of the works of I. I. Bashmakov is associated primarily with application of folklore plots and images, as well as folklore artistic and stylistic peculiarities, based on which his works are attributed to aesthetic row of the “third culture”.
Soteriological context of the image a righteous man in fictional prose of I. S. Shmelyov.
Authors: Muratova Tat'yana Anatol'evna , Saichenko Valeriya Viktorovna
Published: April 2021

The object of this research is the embodiment of the Orthodox anthropological ideal in the works of I. S. Shmelyov. Among multiple images of a righteous man described in the literature, I. S. Shmelyov in his works features “righteousness in the world”. Dilogy “Summer of the Lord” and “Pilgrimage” is selected as an example, namely the image of Gorkin as church-going person among others. His image reflects a peculiar worldview model that reconciles the contradictions of worldly and religious life, due to the dominant of Christocentrism — the uniform principle of an Orthodox person. Through the prism of soteriological attitudes, the author traces in the image of Gorkin the embodiment of the principles of Christian morality, love for the neighbor, and orientation towards the Prototype. The main conclusions consist in development of the original concept of a church-going person, which is based on the Orthodox understanding of human. The author distinguishes between the Orthodox and the abstract spiritual, which is essential for an adequate interpretation of the applied artistic method. Based on Shmelev's reference to the fundamentals of Orthodox anthropology, the interpretation of images suggests using the theological concepts and the elements of patristic teachings. A sequential, rather than fragmentary analysis, is carried out on a specific example of the image of Gorkin. The methodological novelty of such approach lies in the establishment of a profound axiological connection between fiction and Christian anthropology, which underlies the artistic uniqueness of Shmelev's works.
MEKANISME PENERAPAN PAJAK PARKIR PADA PT BARRU BARAKAH PROPERTI
Authors: Wirayanti Uswatun khasanah , Ilham Ilham , Den ka Veronika sari
Published: April 2021

Penelitian ini bertujuan untuk mengetahui penghitungan, penyetoran dan pelaporan Pajak Parkir pada PT Barru Barakah Properti dan untuk mengetahui PT Barru Barakah Properti sebagai Wajib Pajak sudah melaksanakan kewajiban perpajakannya sesuai dengan peraturan perpajakan yang berlaku. Penelitian ini menggunakan teknik analisis deskriptif kualitatif. Data penelitian ini di peroleh dari hasil wawancara langsung dengan staff tax PT Barru Barakah Properti dan Pegawai KTU UPTD Parkir Badan Pendapatan Daerah Kota Makassar. Hasil dari penelitian ini menunjukkan bahwa mekanisme penghitungan telah dilakukan dengan mengalikan dasar  pengenaan pajak dengan tarif sebesar 30% (tiga puluh persen) yang berlaku di wilayah kota Makassar, mekanisme penyetoran dan pelaporan pajak parkir telah dilakukan tepat waktu sesuai dengan peraturan daerah yang berlaku. PT Barru Barakah Properti sebagai wajib pajak parkir telah melaksanakan kewajiban perpajakannya sesuai dengan peraturan perpajakan yang berlaku yaitu Undang-undang Nomor 28 tahun 2009 dan Peraturan Daerah kota Makassar Nomor 2 Tahun 2018 tentang Pajak Daerah.
EVALUASI PENENTUAN HARGA POKOK PRODUK UNTUK MENENTUKAN HARGA JUAL PADA PT INDOBERKA INVESTAMA
Authors: Sari Joti mustika , Pirmaningsih Lilik
Published: April 2021

Harga pokok produksi adalah keseluruhan biaya yang dikeluarkan atau digunakan untuk proses produksi barang mulai dari bahan baku, biaya overhead dan biaya tenaga kerja, sehingga menghasilkan barang jadi yang bisa untuk dijual. Penelitian merupakan studi kasus dengan deskriptif kuantitatif dilakukan dengan perhitungan dengan metode Full Costing  dan penetapan harga jual menggunakan metode Cost Plus Pricing.  Hasil penelitian yang menunjukkan bahwa harga pokok produksi yang dihitung menggunakan metode Full Costing menghasilkan penetapan harga jual dengan metode Cost Plus Pricing yaitu untuk produk C 75 X 0,75 IBI Rp. 59.980,87 per batang; C 75 X 1,00 Rp. 77.151,00 per batang; Reng I-1A Rp. 22.943,36 per batang; Reng I-100A Rp. 24.978,50 per batang; Spandek 0,30 IBI Rp. 161.146,70 per lembar; dan Hollow IBI Rp. 26.102,00 per batang.
ESTABLISHMENT OF A RELIGIOUS CULTURE IN SCHOOL
Authors: Ubabuddin Ubabuddin , Nasikhah Umi , Subowo Adi
Published: April 2021

The moral crisis that occurs today makes an anxiety for all circles, not least schools as an institution that prints a generation of directors are constantly demanded to improve services in order to produce knowledgeable output, and good character. Various events such as brawl, promiscuity, abuse of illegal drugs, immoral acts, sexual harassment always adorn the school. If the abuse is allowed to continue, then all moral depravity will become a bad culture in school. Education is expected to provide a way out and have a role in shaping human beings who are intellectual and Islamic. To realize it all, it is important to make the school atmosphere with religious culture through planting, habituation, cultural imitation based on Islamic shari'ah by all school residents.
THE CONCEPT OF ISMAIL RADJI AL-FARUQI ISLAMIC EDUCATION AS A SOLUTION IN THE MILLENNIAL ERA
Authors: Sa'diyah Halimatus
Published: April 2021

Of several problems in the Millennial era, one of them is the westernization of science, including Islamic education. So it is necessary to find a solution by Islamizing science as conceptualized by Ismail Radji al-Faruqi. This research is a library research using qualitative descriptive analysis. Data was collected from various kinds of reading sources in the form of scientific articles and books and other supporting references, then ancarried content analysis was in-depthout to find solutions to educational problems in the millennial era. The results of the research show that the concept of Islamic education Ismail Radji al-Faruqi is a leading Muslim intellectual who has responded positively to the development of science and technology, but he still puts the principle of tauhid in his idea of ​​Islamization of science. Through a work plan arranged systematically with five objectives and twelve stages al-Faruqi was able to realize his program. It is important to review the concept of education to be re-realized in the current millennial era.
THE RELATIONSHIP BETWEEN SPIRITUAL INTELLIGENCE AND THE JUST ATTITUDE OF STUDENTS AT SMP RAHMAN WAHID MOJOGENENG
Authors: Asfina Taufiqillah Ridha , Abidin Chasiru Zainal , Rohmad M. Ali
Published: April 2021

Spiritual intelligence is closely related to how a person maintains the principles and responsibilities to carry out these principles while maintaining balance and creating appropriate value benefits. A person is not called spiritually intelligent, if he only cares about the hereafter but blinds himself to his mission in the world to Allah. Fair is a word that is quite difficult to describe, the meaning of fair is associated with law or something that is inherent in the rights of each individual. Fair is human values ​​and a pillar for aspects of life, both individuals, families and communities. The objectives of this study were: 1) to determine the spiritual intelligence of students at SMP Rahman Wahid Mojogeneng 2) to determine the fair attitude of students at SMP Rahman Wahid Mojogeneng 3) to test empirically the relationship between spiritual intelligence and fair attitude of students at SMP Rahman Wahid Mojogeneng. This research is a quantitative study with a correlation approach. The research population used was all students of SMP Rahman Wahid Mojogeneng. Sampling with stratified sampling technique was taken 34 students as respondents. Data collection using questionnaires, observation, and documentation. The results showed: 1) The spiritual intelligence of students at SMP Rahman Wahid Mojogeneng was generally in the high category with an average score of 36 because it was between the criteria for a score of 31 ≤ 40.2) The fair attitude of students at SMP Rahman Wahid Mojogeneng was generally included in moderate category with an average score of 37 because it is between the interval 31 ≤ 40. 3) There is a significant positive relationship between spiritual intelligence and fairness of students at SMP Rahman Wahid Mojogeneng with a correlation value of 0.618. The result of the correlation shows the level of correlation is strong with interpretation 0.610-0.800.
THE ROLE OF CHARACTER EDUCATION TO IMPROVE THE MORAL OF THE NATION
Authors: Lestari Astriani , Surur Agus Miftakus
Published: April 2021

It has become a shared awareness that the world of education is a way that has been done by human beings throughout their lives to become a means of transmitting and transformation of both values ​​and science. Thus the strategic world of education as a means of transmission and transformation of values ​​and knowledge, so in order to instill and develop the character of this nation, it cannot be separated from the role played by the world of education. Character education is important for human life, so the role played by the education world must not only show moral knowledge, but also love and be willing to act morally. In addition to education in schools, of course education in the family becomes the most important thing in instilling character education in children. The environment is also very supportive of that, so in addition to the family, school and also a good environment will also be embedded in good character for children.With so life becomes a child who has good character who will be the successor to a nation that has high character.
ISLAMIC EDUCATION VALUE IN THE PROCESS OF MANEJEK HUMA (MEMBANGUN RUMAH) FOR DAYAK KAHAYAN / NGAJU (BIAJU) AT BAHAUR HULU VILLAGE
Authors: Rianti Heni , Syaipullah Syaipullah , Muslimah Muslimah , Hamdanah Hamdanah
Published: April 2021

The aim of this research was to know how the process Manejek Huma in the Dayak culture of kahayan / ngaju (biaju) in Bahaur Hulu Village and to analyze the values of Islamic education in the process of Manejek Huma in Dayak Kahayan / ngaju (biaju) Tribe at Bahaur Hulu Village. This research used an ethnographic approach. In collecting data the researchers used observation, interview and documentation. The result show that the Islamic education value in the process of mockinghuma the Dayak Kahayan / Ngaju was reading basmallah, praying, reading the Qur'an praying and giving thanks to Allah, always giving respect to the Prophet Muhammad SAW. The indigenous culture and customs and traditions of this tribe have absorbed a lot from the culture and customs of the Banjar Malay tribe.

Keyword : Islamic Educaion ValueIslamic Educaion Value; Manajek Huma; Dayak Kahayan/Ngaju (Biaju)
THE DEVELOPMENT OF STUDENTS’ ENGLISH WORKSHEET BASED ON PHONETIC TRANSCRIPTION AT THE TENTH GRADE OF MA MA’ARIF ROUDLOTUT THOLIBIN METRO
Authors: Safita Anggun Tika , Zuniati Mai
Published: April 2021

Education is a conscious and planned effort to create a good learning atmosphere and learning process so that students actively develop their potential. But so far the teacher only uses textbooks only to provide material and questions without training students' pronunciation, because in the textbooks the pronunciation is small and even the teacher doesn't pay attention to students in pronunciation. So that development is needed for the learning process. This study aims to develop a Worksheet based on Phonetic transcription class X MA MA'arif Roudlotut Tholibin 28 Purwosari north Metro. This research is a research and development study. The steps in this research are: Potential and Problems, Data Collection, Product Design, Product Revision, Product Validation, Product Trial, Revision After Trial. The results of this study in the form of a Phonetic transcription class X-based Science Worksheet can be used in the learning process at MA Ma'arif Roudlotut Tholibin 28 Purwosari north Metro, based on responses and validator ratings of the developed teaching materials, obtained results categorized as good.  This shows that teaching materials developed based on phonetic transcription in class X can be used as teaching materials for MA MA'arif Roudlotut Tholibin 28 Purwosari north Metro students.
As possíveis causas da não adesão à imunização no Brasil: uma revisão de literatura
Authors: Corrêa Shesllen Mikaelly Cruz , De Vasconcelos Pedro Fonseca , Dos Passos Jamille Santos , Marques Valéria Gomes , Tanajura Nadynne Porto Magalhães , Do Nascimento Davi Ramos , Silva Camila Santana , Magalhães Laila Pereira , Neves Lilian Rhodes , Silveira Michelle Beatriz Santos
Published: April 2021

Objetivo: Revisar e analisar quais as possíveis causas que levam a não adesão a imunização no Brasil. Revisão bibliográfica: A vacinação é reconhecida como uma prática de intervenção que previne doenças com grande potencial de causar morbidades e mortalidade em massa. Entretanto, posturas comportamentais, como a promoção de ideias antivacina e falta de conscientização da população mais jovem acerca da gravidade das doenças imunopreveníveis, são alguns dos fatores que atualmente contribuem para a queda das taxas de imunização e o retorno de doenças até então erradicadas. Considerações finais: Este constructo é de fundamental importância, pois irá prover embasamento teórico-metodológico para a comunidade acadêmica e científica sobre as possíveis motivações da recusa populacional quanto à adesão da imunização e a análise da cobertura vacinal no Brasil. Ademais, por meio da análise dos fatores que levam a população a não se vacinar, possibilitará a construção de debates que sustentem o planejamento de estratégias para impulsionar a adesão à imunização.
ANALOGS OF INFORMATION SYSTEMS AND TECHNOLOGIES FOR EVALUATING THE EFFECTIVENESS OF INVESTMENT PROJECTS
Authors:   Kursk State Medical University, VLASOVA O.V
Published: April 2021

As part of Russia's transition to a digital economy, businesses and administrative institutions have begun to introduce information technologies into their activities. The process of commissioning any information product is a complex and lengthy process that lasts from six months to several years, requiring large financial investments. One of the most relevant areas in the economy that require the use of information technologies is the assessment of the effectiveness of investment activities. Investing is always associated with certain risks, and the success of the project is influenced by a large number of various factors. The impact of adverse factors can be leveled by using the latest data analysis techniques to generate comprehensive information for the organization's management. Today, according to some evaluation methods, they are taken into account as part of the decision on the effectiveness of the investment project. A number of applied methods suggest using and taking into account possible risks to stabilize the position of investors. Information systems and the technologies they implement offer various tools for solving the problem of preinvestment analysis. The development of areas of informatics and computer engineering opens up more global opportunities for the development of information systems for the analysis of investment activities. It is thanks to the tools of analytical modeling that it has become possible to consider risks more widely and make more accurate forecasts. Also, the emergence of expert decision-making systems made it possible to perform data analysis operations with minimal human participation.
PROBLEMS OF PRELIMINARY INFORMATION WHEN MOVING GOODS ACROSS THE CUSTOMS BORDER OF THE EURASIAN ECONOMIC UNION BY SEA
Authors:   Vladivostok state University of Economics and service, SMOLYANINOVA E.N ,   Vladivostok state University of Economics and service, SEBADAS I.A
Published: April 2021

The active development of international trade has created the need for a qualitatively new level of development of customs regulation within the framework of the Eurasian economic Union (EAEU). One of the main tasks in this direction is the widespread introduction of the mandatory pre-notification mechanism (PM). Therefore, this technology has become a priority for improving information technologies in the Russian customs. However, at present, not all PM problems have been solved when moving goods across the customs border of the EAEU by sea. Sea transport is one of the most complex means of moving goods to implement such a mechanism. The article substantiates the relevance of studying modern problems of individual entrepreneurs when moving goods across the customs border of the EAEU by sea. The article presents the results of a study of the opinions of various domestic authors of articles and theses of the higher attestation Commission in recent years on the topic of research on the practice of PM application in the EAEU. Specific proposals were put forward on the necessary and possible ways to address these key issues, the implementation of which will improve customs regulation, increase port capacity, save time and reduce costs for participants in foreign economic activity.
PARTISIPASI POLITIK DALAM PEMILIHAN UMUM KEPALA DAERAH DI DESA PERAPAKAN KABUPATEN SAMBAS
Authors: Hemafitria Hemafitria , Novianty Fety Novianty Fety , Fitriani Fitriani
Published: April 2021

Partisipasi politik masyarakat erat dengan demokrasi suatu negara. Dalam demokrasi negara, kedaulatan berada di tangan rakyat, yang pelaksanaannya melalui kegiatan bersama untuk menentukan tujuan-tujuan, serta masa depan dan untuk menentukan orang-orang yang akan memegang pimpinan. Partisipasi politik suatu kegiatan masyarakat dalam memilih pemimpin baik secara langsung atau tidak langsung dan ikut aktif dalam kehidupan politik. Metode yang digunakan dalam penelitian ini adalah kualitatif dengan bentuk deskriptif, subjek dalam penelitian ini adalah Kepala Desa, Tokoh Masyarakat, dan Tokoh Pemuda. Teknik dalam penelitian data ini observasi, wawancara, dokumentasi. Hasil dari penelitian ini dapat menyatakan bahwa wujud Partisipasi politik masyarakat dapat dipakai sebagai ukuran untuk menilai penilaian stabilitas sistem politik kepuasan dan ketidakpuasan warga kepala negara yang rendahnya partisipasi politik masyarakat dalam pemilihan umum kepala daerah masyarakat yang aktif menggunakan hak suara nya dalam melaksanakan pemilihan umum umum daerah dan ikut serta dalam kegiatan politik. Faktor mempengaruhi politik masyarakat dalam pemilihan umum kepala daerah adalah faktor kesadaran dan kepercayaan masyarakat kepada pemerintah yang tentang pengetahuan masyarakat tentang politik. Upaya Partisipasi politik masyarakat dalam pemilihan umum kepala daerah dalam melakukan kegiatan sosialisasi,
A Data Scope Management Service to Support Privacy by Design and GDPR Compliance
Authors: Piras Luca , Al-Obeidallah Mohammed Ghazi , Pavlidis Michalis , Mouratidis Haralambos , Tsohou Aggeliki , Magkos Emmanouil , Praitano Andrea
Published: April 2021

In order to empower user data protection and user rights, the European General Data Protection Regulation (GDPR) has been enforced. On the positive side, the user is obtaining advantages from GDPR. However, organisations are facing many difficulties in interpreting GDPR, and to properly applying it, and, in the meanwhile, due to their lack of compliance, many organisations are receiving huge fines from authorities. An important challenge is compliance with the Privacy by Design and by default (PbD) principles, which require that data protection is integrated into processing activities and business practices from the design stage. Recently, the European Data Protection Board (EDPB) released an official document with PbD guidelines, and there are various efforts to provide approaches to support these. However, organizations are still facing difficulties in identifying a flow for executing, in a coherent, linear and effective way, these activities, and a complete toolkit for supporting this. In this paper, we propose the design of such flow, and our comprehensive supporting toolkit, as part of the DEFeND EU Project platform. Within DEFeND, we identified candidate tools, fulfilling specific GDPR aspects, and integrated them in a comprehensive toolkit: the DEFeND Data Scope Management service (DSM). The aim of DSM is to support organizations for continuous GDPR compliance through model-based Privacy by Design analysis. Here, we present DSM, its design, flow, and a preliminary case study and evaluation performed with pilots from the healthcare, banking, public administration and energy sectors.
Boosting Dissolution-Dynamic Nuclear Polarization by Multiple-Step Dipolar Order Mediated 1H->13C Cross-Polarization
Authors: Elliott Stuart J. , Cala Olivier , Chappuis Quentin , Cousin Samuel , Ceillier Morgan , Decker Venita , Jannin Sami
Published: April 2021

Dissolution-dynamic nuclear polarization can be boosted by employing multiplecontact cross-polarization techniques to transfer polarization from 1H to 13C spins. The method is efficient and significantly reduces polarization build-up times, however, it involves high-power radiofrequency pulses in a superfluid helium environment which limit its implementation and applicability and prevent a significant scaling-up of the sample size. We propose to overcome this limitation by a stepwise transfer of polarization using a lowenergy and low-peak power radiofrequency pulse sequence where the 1H®13C polarization transfer is mediated by a dipolar spin order reservoir. An experimental demonstration is presented for [1-13C]sodium acetate. A solid-state 13C polarization of ~43.5% was achieved using this method with a build-up time constant of ~5.1 minutes, leading to a ~28.5% 13C polarization in the liquidstate after sample dissolution. The low-power multiple-step polarization transfer efficiency with respect to the most advanced and highest-power multiple-contact cross-polarization approach was found to be ~0.69.
Efficiency Gains for Thermally Coupled Solar Hydrogen Production in Extreme Cold
Authors: Kölbach Moritz , Rehfeld Kira , May Matthias
Published: April 2021

Hydrogen produced from water using solar energy constitutes a sustainable alternative to fossil fuels, but solar hydrogen is not yet economically competitive. A major question is whether the approach of coupling photovoltaics via the electricity grid to electrolysis is preferential to higher levels of device integration in ‘artificial leaf’ designs. Here, we scrutinise the effects of thermally coupled solar water splitting on device efficiencies and catalyst footprint for sub-freezing ambient temperatures of -20C. These conditions are found for a significant fraction of the year in many world regions. Using a combination of electrochemical experiments and modelling, we demonstrate that thermal coupling broadens the operating window and significantly reduces the required catalyst loading when compared to electrolysis decoupled from photovoltaics. Efficiency benefits differ qualitatively for double- and triple junction solar absorbers, which has implications for the general design of outdoor-located photoelectochemical devices. Similar to high-efficiency photovoltaics that reached technological maturity in space, application cases in polar or alpine climates could support the scale-up of solar hydrogen at the global scale.
Comparison of Prevalence and Risk Factors in COPD Patients With and Without History of Smoking
Authors: Ethirajan Nandagopal  , Sumithra M  , Meenakshi N
Published: April 2021

A prospective cross-sectional study to compare the prevalence and risk factors in chronic pulmonary obstructive disease (COPD) patient with and without a history of smoking. This was an observational study conducted in the department of respiratory medicine, Chettinad Hospital and Research Institute (CHRI), Kancheepuram. A total of 206 patients with COPD, diagnosed as per GOLD criteria were enrolled in the study. Out of 206 COPD patients, 164 (79.61%) were men, and 42 (20.4%) were women and their mean age was 62.88 (± 9.53). The prevalence of COPD patients in smokers/ex-smokers were 125 (60.7%) and 81 (39.3%) in never smokers. There were 75 patients (92.59%) in the never smoker cohort and 72 patients (57.6%) in the ex-smoker/smoker cohort found to have at least one non-smoking risk factor for COPD. Biomass Exposure (39.50%), Passive Smoking (22.22%, P=), Co-existing Asthma (22.22%) were the non-smoking risk factors which were found to be present significantly higher in never smokers than smokers/ex-smokers, and the difference was statistically significant (<0.05). A higher proportion of severe patients were in smokers/ex-smokers than non- smokers (41.6% vs 27. 1%). Patients with moderate disease in both groups were found to be of equal proportion (12% vs 11. 11%). The results of the study reiterate that a significant proportion of COPD patients were never smokers and prevalence of non-smoking risk factors were more common in that population.
Psychological impact of COVID-19 outbreak on nurses: A systematic review
Authors: Aruna Jothishanmugam  , Sithara Begum  , Amani Abdelgader Mohammed Abdelgader  , Hawa Ibrahim Abd AllaHamid  , Nagla Abdelmonim Abdelrahim Abdalghani
Published: April 2021

The sudden exposure of COVID-19 has affected more than one hundred million people live and heath across the world. COVID-19 pandemic not only affected the lives of people, and it also affected the functions of Health care systems and also produced an overburden to the Health care systems. During the COVID-19 period, health care workers are affected by psychological problems, especially nurses working in the hospital and protecting the lives of everyone affected with COVID -19 infections. It is important to identify the issues that producing psychological problems among nurses, and it is necessary to support the nurses during their struggle. The researcher considering these issues, did a rapid systematic review to identify the percentage of nurses affected with psychological impact and causes for psychological impacts among nurses during COVID19 outbreaks. The researcher searched Google scholar and Science direct for selecting relevant research articles. The searched the studies based on the title, Study design, population, psychological problems of the nurses like anxiety, depression, fear, stress, sleeping problems, key words of nursing, psychological problems, and COVID-19. A PRISM protocol was used for selecting relevant research articles. According to the systematic review, the result shows that 26.4% of the nurses had depression, 40.8% had anxiety, and 42.7% had somatic symptoms, 50.5% had stress, and 91.2% had fear. The nurses are at risk of psychological problems and physical problems as being due to Covid-19. Effective intervention should be planned on nurses' issues, and it helps to strengthen the mental health of nurses.
Molecular Docking Study of α-Cyclodextrin With Psoralen: MDA-MB-231 Cancer Cell
Authors: Prasheena Russell S  , Steiny R P  , Prema Kumari J
Published: April 2021

Psoralen is an important bioactive component, isolated from the leaves of Ficus carica (Fig). Psoralen is proved to inhibit breast cancer cell growth and in tumor bearing mice the function of osteoblasts and osteoclasts is regulated. It is difficult to treat Triple-Negative Breast Cancer, a sub type of breast cancer. On treating Fig leaf extract, it is found that the leaf extract inhibits the proliferation of MDA-MB-231, which is a TNBC cell line, but not MCF10A cells, which is normal breast epithelial cell line. To increase the stability, solubility, volatility, it is beneficial to encapsulate natural products with α-Cyclodextrin (α-CD). Cyclodextrin constituted by 6 glucose units are termed as α-Cyclodextrin. Compared to host molecule guest: host inclusion complexes exhibit improved chemical or biological properties. Main aim of the study is interaction of Psoralen with α-CD and MDA-MB-231 Cancer cell with α-CD: Psoralen inclusion complex by molecular docking studies. 3D structures of Psoralen, α-CD and MDA-MB-231 cancer cell are obtained and docking is carried out using PatchDock server. Model which is highly favorable will have a high score. Energetically favorable and most probable structures of α-CD: Psoralen and MDA-MB-231 cancer cell: α-CD Psoralen inclusion complex has a score of 1762 and 6230 respectively.
Controlled drug release of levofloxacin from poly (acrylamide) hydrogel
Authors: Madhusudana T.  , Mamatha G. P.  , Demappa T.  , Satyanarayan N. D.
Published: April 2021

Hydrogels are 3D polymer networks capable to absorb and release water or biological fluids. They are stimuli-responsive materials, which can show rapid volume changes with response to small changes in environmental parameters such as ionic strength, pH, and temperature. In this work, we performed a synthesis of Poly(acrylamide) hydrogel and tested for controlled release of levofloxacin hemihydrate as a model drug. We used sodium metabisulfite and potassium persulphate as free radical initiators to prepare hydrogel with methylenebisacrylamide as a crosslinker. Characterization of hydrogel was performed by TGA, SEM, and FT-IR. Swelling study and drug release were performed at pH 1.2 and 7.4 solutions, identical to the gastrointestinal fluid at 37°C (human body temperature) to examine possible site-specific drug delivery. UV-Visible spectrophotometer was used to measure the concentration of drug release. Results exhibited the pH and temperature-dependent drug release. The amount of drug release was found to be 17% and 99% in acidic and alkaline pH of 1.2 and 7.4, respectively, after 6 hours.
Formulation and Evaluation of Taste Masking Lercanidipine Hydrochloride Oral Disintegrating Tablets
Authors: Ravi Kumar Kota  , Pavankumar Krosuri  , Madhusudhana Chetty C
Published: April 2021

Lercanidipine is an antihypertensive drug. It is a dihydropyridine class of calcium channel blockers. It is extremely bitter. The reason for this exploration was to build up a non-bitter orally breaking down the tablet of inadequately solvent medication viz Lercanidipine. The bitterness of drug, masked through complexing Tulsion 339 in various ratios. Sodium starch glycolate, crospovidone, low substituted hydroxypropyl cellulose selected as super disintegrants in the formulation. The formulated tablets were assessed for various properties like Drug content, crushing strength, friability, wetting time, water retention proportion, breaking downtime and in-vitro disintegration time and dissolution studies. The disintegration time obtained in the range between 38.46-51.40 seconds. Release studies observed between 5 to 30 minutes. From the prepared formulations, formulation using Low substituted hydroxypropyl cellulose with 5% concentration showed 98.89% drug release within 30minutes. Thus F9 was considered as best among the other formulations With effective dissolution and improves patient intake. Drug release Kinetic analysis (r2) based on best curve fitting method for optimized lercandipine formulation showed first order kinetics proves that the drug release depends upon its concentration.
Comparative in vitro dissolution studies of fixed-dose combination formulations: analgesic tablets of acetaminophen/caffeine
Authors: Medina-López J R  , Sánchez-Badajos S  , Carreto-Jiménez R M  , García-Hernández P  , Contreras-Jiménez J M
Published: April 2021

A simple and rapid UV derivative method with zero-crossing determinations was developed for estimation of acetaminophen (ACE) and caffeine (CAF) in fixed-dose combination formulations. The first-derivative of standard solutions of both drugs were used and ACE and CAF were quantified at 273.0 and 216.5 nm, respectively. The method was validated, and it was applied to dissolution studies with the USP Apparatus 2 and flow-through cell (USP Apparatus 4). Dissolution profiles comparisons (generic vs reference) were carried out with model-independent and model-dependent approaches. Mean dissolution time and dissolution efficiency were calculated and significant differences, in almost all calculated parameters, were found (p<0.05). Weibull, logistic, Gompertz, and Probit models were used to fit dissolution data and Probit was the best-fit model that describes the in vitro dissolution performance of ACE and CAF. Using t50% data, derived from this fit, dissolution profiles of ACE in USP Apparatus 2 were significant different (p<0.05). The proposed UV derivative method generates reliable information that can be compared with published results. Dissolution studies of fixed-dose combination formulations are important because quality of generic drug products depends on quality of references. It is essential to maintain a post-marketing evaluation of formulations with analgesic drugs mixed with CAF to offer the population high quality medicines.