bluuebunny/crossref_metadata_2025 huggingface dataset:
CHEMICAL COMPOSITIONS OF TWO BROWN SEAWEED SPECIES FROM KARIMUN JAWA, INDONESIA
Authors: Siahaan Evi Amelia , Asaduzzaman A.K.M. , Pangestuti Ratih
Published: October 2019

Seaweeds are potentials to be developed as alternative source in foods and pharmaceuticals. In this study, chemical compositions of two brown seaweeds species from Karimun Java Indonesia Padina australis and Turbinaria conoides were investigated. Proximate results showed that both seaweeds contain high amount of carbohydrates and ashes. Mineral contents of P. australis and T. conoides follow the orders of Na>Mg>Fe>K>Ca>Zn>Cu and Na>Mg>K>Fe>Zn>Ca>Cu, respectively. Almost all essential amino acids (including histidine, isoleucine, leucine, phenylalanine, threonine, valine and lysine) were present in both seaweeds. Amino acid profiles showed that both seaweed contain polyunsaturated fatty acids (PUFA) with T. conoides contain higher amount of EPA (8.58 ± 0.22 g/100 g of total fatty acids) and DHA (6.05 ± 0.21 g/100 g of total fatty acids). The findings of this study have provided evidence that brown seaweeds were nutritious and potential to be utilized for producing functional ingredients in food. Further, P. australis and T. conoides can be used as candidate to be used in food industries to increase shelf-life of food items for human consumption, and use to deter deleterious free radical-induced life-threatening diseases.
PRACTICAL GUIDELINES FOR ASSESSING CORAL CALCIFICATION VIA COMPUTED TOMOGRAPHY
Authors: Nurhati Intan Suci
Published: October 2019

Coral calcification as the product of extension rate and skeletal density, is projected to change under marine environmental changes of local (e.g., sedimentation, eutrophication) and global (e.g., warming, ocean acidification) scales. For the regional effort to monitor the ecological impacts of ocean acidification on coral reef ecosystems, the Intergovernmental Oceanographic Commission Sub-Commission for the Western Pacific (IOC-WESTPAC) has incorporated an interdisciplinary approach that includes monitoring of seawater carbonate parameters, coral calcification, net calcification minus bioerosion, and reef community structure. Currently, there is a need to formulate a standard operating procedure (SOP) for assessing coral calcification over the recent years via coral cores. The SOP needs to yield accurate data in a cost-effective way that can be applied by researchers in the region. High variation of coral calcification parameters between coral colonies warrants a sufficiently large number of samples thus a rapid method for analyzing coral extension rate, skeletal density, and calcification. This paper outlines practical guidelines for assessing coral calcification from the field to laboratory using the three-dimensional computed tomography (CT) method.
SITE SUITABILITY ANALYSIS FOR COMMUNITY-BASED TROPICAL SEA CUCUMBER HOLOTHURIA SCABRA GROW-OUT IN NORTH SULAWESI WATERS
Authors: Rizqi Marenda Pandu , Supono -
Published: October 2019

North Sulawesi, a region that has experienced a decreasing population of commercial sea cucumbers in Indonesia, has recently been designated an aquaculture development area. Recent developments of sea cucumber Holothuria scabra hatchery technology have successfully enabled the small-scale enterprise to produce hatcheryreared sandfish for restocking purposes. However, the grow-out phase requires considerable resources including ex-situ grow-out sites, labor, and distribution. This study aims to investigate the suitability of some potential grow-out sites for juvenile H. scabra in North Sulawesi waters. Three traditional sea cucumber fishing grounds in coastal areas of North Minahasa regency in North Sulawesi, i.e., Tanjung Merah, Tasikoki and Makalisung, were examined to determine their suitability as a grow-out site. Several criteria encompassing bioecological (native sea cucumber population, seagrass bed population, competitor/predator), environmental (substrate, protection to weather, water quality, tidal cycle), and technical/support (access, safety, labor) were assessed in each site. Site suitability analysis using a multi-criteria decision-making tool, Analytical Hierarchy Process (AHP), shows that Tasikoki has the highest suitability score (48.94%) followed by Tanjung Merah (27.18%) and Makalisung (23.88%). Tasikoki scores higher than the two other sites in 7 out of 11 sub-criteria, including native sandfish population, seagrass species, substrate, weather protection, safety, and community support. Our finding suggests that Tasikoki is bioecologically, environmentally, and technically the best potential site to be developed for H. scabra juvenile grow-out.
BRIDGING COASTAL RESEARCH PROGRAM BETWEEN INDONESIA AND JAPAN
Authors: Arifin Zainal , Saito Hiroaki
Published: October 2019

The JSPS Core-to-Core Research and Education Network on Coastal Ecosystems in Southeast Asia (RENSEA) 2016-2019 program has benefited Indonesian and Japanese researchers, as well as researchers in Southeast Asia. The program consists of three research groups; G1: Physical oceanography, G2: Biodiversity, and G3: Marine pollution. Considering the vast geographical area of Indonesia, managing joint research at the national level is challenging. Few active members, lack of funding, as well as the reorganization of research institutions over the last two years, pose more challenges. Funding as an engine of research execution has become highly competitive in recent years; therefore, research groups need to be more active in securing available funding at the national level, such as the COREMAP-CTI demand-driven research program, LPDP research scheme, and INSINAS research fund. From the science management perspective, the regional Core-to-Core RENSEA program needs to adapt to global trends in marine science with closer communication during the planning and execution of research projects. We recommend that joint research projects are developed to have more joint supervisory of graduate students; therefore, the collaboration would result in joint research publications and formal degrees for young scientists at the end of the program. In this way, the JSPS Core-to-Core program would have more significant benefits to the development of coastal science and research cooperation.
PESQUISAR ESCOLAS: “ABORDAGEM DO CICLO DE POLÍTICAS” E “TEORIA DA ATUAÇÃO POLÍTICA” EM DISCUSSÃO
Authors: Hojas Viviani Fernanda
Published: October 2019

Este artigo reúne reflexões realizadas durante e sobretudo após a finalização de pesquisa de doutorado, que teve como objetivo analisar as relações que as políticas produzidas no interior das escolas estabelecem com o Sistema de Avaliação de Rendimento Escolar do Estado de São Paulo (SARESP). Para subsidiar a referida investigação, foram adotadas algumas formulações desenvolvidas por Stephen Ball e colaboradores, as quais sustentam que as políticas educacionais são caracterizadas por negociações e embates que não se encerram na ação estatal e que é necessário levar em conta as ações exercidas pelos atores escolares nas análises. Tal perspectiva teórico-metodológica, apesar de valorizar as experiências micropolíticas construídas nas escolas e se distanciar das investigações que conferem centralidade ao Estado na produção de políticas, apresenta certa fragilidade que será discutida ao longo do texto. Por fim, são apresentadas algumas ferramentas conceituais elaboradas por Silvio Gallo como uma nova forma de compreender e pesquisar o cotidiano escolar.
DISCURSO E RESISTÊNCIA NA OBRA POÉTICA DE ELIANE POTIGUARA EM METADE CARA, METADE MÁSCARA
Authors: Da Silva Neuza Maria Correa , Soares da Silva Giacomolli Dóris Helena
Published: October 2019

Este artigo tem por intuito articular uma reflexão acerca de questões imanentes ao discurso exarado no livro Metade cara, metade máscara. Pretendemos acentuar as regularidades arquivadas nas formações discursivas que atravessam a fala de Eliane Potiguara, norteiam sua poesia e sua palavra em movimento, nos norteando pelos teóricos Michel Foucault e Eni Orlandi para, a partir da fala de Potiguara, observarmos a ordem discursiva que a interpela. Pretendemos observar em que sujeito ela se converte ao tomar posse da palavra e dar vazão ao viver dos povos indígenas brasileiros. Pela análise da referida obra, percebemos que Potiguara vem, por meio de seu discurso poético, autobiográfico ou em forma de escrita jornalística de informação, exaltar a determinação e a firmeza da luta dos povos originários.
Machine Learning–Based Computational Models Derived From Large-Scale Radiographic-Radiomic Images Can Help Predict Adverse Histopathological Status of Gastric Cancer
Authors: Li Qiong , Qi Liang , Feng Qiu-Xia , Liu Chang , Sun Shu-Wen , Zhang Jing , Yang Guang , Ge Ying-Qian , Zhang Yu-Dong , Liu Xi-Sheng
Published: October 2019

INTRODUCTION:

Adverse histopathological status (AHS) decreases outcomes of gastric cancer (GC). With the lack of a single factor with great reliability to preoperatively predict AHS, we developed a computational approach by integrating large-scale imaging factors, especially radiomic features at contrast-enhanced computed tomography, to predict AHS and clinical outcomes of patients with GC.

METHODS:

Five hundred fifty-four patients with GC (370 training and 184 test) undergoing gastrectomy were retrospectively included. Six radiomic scores (R-scores) related to pT stage, pN stage, Lauren & Borrmann (L&B) classification, World Health Organization grade, lymphatic vascular infiltration, and an overall histopathologic score (H-score) were, respectively, built from 7,000+ radiomic features. R-scores and radiographic factors were then integrated into prediction models to assess AHS. The developed AHS-based Cox model was compared with the American Joint Committee on Cancer (AJCC) eighth stage model for predicting survival outcomes.

RESULTS:

Radiomics related to tumor gray-level intensity, size, and inhomogeneity were top-ranked features for AHS. R-scores constructed from those features reflected significant difference between AHS-absent and AHS-present groups (P < 0.001). Regression analysis identified 5 independent predictors for pT and pN stages, 2 predictors for Lauren & Borrmann classification, World Health Organization grade, and lymphatic vascular infiltration, and 3 predictors for H-score, respectively. Area under the curve of models using those predictors was training/test 0.93/0.94, 0.85/0.83, 0.63/0.59, 0.66/0.63, 0.71/0.69, and 0.84/0.77, respectively. The AHS-based Cox model produced higher area under the curve than the eighth AJCC staging model for predicting survival outcomes. Furthermore, adding AHS-based scores to the eighth AJCC staging model enabled better net benefits for disease outcome stratification.

DISCUSSION:

The developed computational approach demonstrates good performance for successfully decoding AHS of GC and preoperatively predicting disease clinical outcomes.
Immunologic aspects of autoimmune thyroiditis
Authors: Kalinin A P , Potemkina Ye Ye , Pesheva N V , Rafibekov D S
Published: October 2019

Autoimmune thyroiditis (AIT) is one of the most important and relevant problems of modern endocrinology due to the lack of study of the etiology, lack of clarity of pathogenetic mechanisms, and the absence of objective and reliable diagnostic methods, including immunological ones.

The last decade is characterized by the appearance of fundamental works devoted to the immunology of autoimmune thyroid diseases. The data need generalization, a critical analysis, since the conclusions of the authors often differ in inconsistency.

AIT takes first place among thyroid diseases. According to V.I. Litvinov, AIT is observed in 20-40% of the adult population, according to foreign authors, in 7.2% of the children. In 90% of cases, hypothyroidism in adults is caused by autoimmune processes, of which 70% is associated with AIT.

The prevalence of the disease is primarily associated with a catastrophic environmental degradation. There are separate studies suggesting that factors associated with urbanization can contribute to the emergence of AIT. M. Podleski et al., N.I. Romanyuk, I.D. Levit revealed a greater incidence of AIT in the urban population compared with the rural one. The effect of iodine on the incidence of AIT is widely studied: a deficiency of a trace element helps to reduce it, and an excess increases it. In the occurrence of AIT, the role of radiation is significant. So, in territories affected by radiation as a result of accidents, AIT is registered 2 times more often (19.2% versus 8.8% in uncharged territory). N.V. Romashkan et al. they associate an increase in the incidence of AIT with increasing general allergization of the population, a significant recent prevalence of viral infections that enhance autoimmunization. The function of the thyroid gland, the peripheral phenotype of T cells and their function are affected by smoking. Nicotine can damage thyroid cells and release thyroglobulin into the blood, and also directly affect the function of T-suppressors.

To date, there are three hypotheses for the pathogenesis of AIT: antigenic damage to the thyroid gland, a defect in specific T-suppressors, and a violation of the regulatory function of thyroid-stimulating hormone. None of the hypotheses is conclusively confirmed. It is possible that all three mechanisms are involved in the emergence and formation of an autoimmune specific process, clinically manifesting themselves in various stages and forms of the disease.
Research and practical conference of endocrinologists of the Armed Forces
Authors: Yakovlev V A , Shustov S B
Published: October 2019

In June 1993, the All-Army Scientific and Practical Conference of Endocrinologists was held in St. Petersburg, dedicated to the memory of Professor D. Ya. Shurygin, Honored Scientist of the Russian Federation, who for a long time headed the endocrinological service of the Armed Forces. The conference was organized by the medical service of the Armed Forces of Russia and the Military Medical Academy.The conference was attended by the chief therapist of the Ministry of Defense of the Russian Federation, corresponding member. RAMS V.T. Ivashkin, endocrinologists of the Military Medical Academy and central military hospitals, a number of leading scientists and endocrinologists of the country from Moscow, St. Petersburg, Saratov and Yekaterinburg, as well as some specialists from neighboring countries. The conference lasted 2 days and consisted of 3 plenary sessions, at which 22 reports were heard. Other participants who submitted abstracts of messages (more than 130 people) could present materials in the form of poster presentations. Conference proceedings published.
Effects of low dehydroepiandrosterone doses on the development of the gonadal hormonal function of young monkeys
Authors: Goncharov N. P. , Butnev V. Yu.
Published: October 2019

The effect of prolonged administration of dehydroepiandrosterone (DHEA) to young male Papyo hamadryas on the subsequent course of sexual maturation was studied. Blood levels of testosterone, hydrocortisone, corticosterone, and 11-deoxyhydrocortisone were radioimmunoassayed over the course. of DHEA administration and after it. No appreciable changes in the said steroid compounds were observed during DHEA administration and soon after it. One year after DHEA administration, when the animals were in the pubertal stage, they had higher testosterone levels in the blood and a statistically higher mass in comparison with age-matched control monkeys. The most marked differences in testosterone levels were observed 2 years after DHEA administration, when the animals grew adult. Their testosterone levels surpassed the normal value by 4.7 times. The authors consider the effect of physiologic doses of DHEA the gonadal hormonal function from the “neurosteroid" concept viewpoint.
The use of second generation sulfonylurea agents and the role of glurenorm in the therapy of non-insulin-dependent diabetes mellitus
Authors: Balabolkin M. I. , Nedosugova L. B.
Published: October 2019

Sulfonylurea drugs stimulate the 1st phase of insulin secretion, activate adenylate cyclase, inhibit phosphodiesterase or cause prolonged depolarization of the beta cell membrane. The peripheral effect of the hypoglycemic action of sulfonylurea drugs is mediated through the effect on insulin receptors. It is clearly shown that sulfonylureas lead to an increase in the number of receptors on target cells (hepatocytes, muscle and adipose tissue, lymphocytes and other cells). It is known that patients with type II diabetes mellitus have a decrease in both the number of receptors and their affinity. The increase in the number of receptors on the membrane of target cells is not due to their de novo synthesis, but by improving the return of the receptor to the membrane from the cytosol, where they are translocated as an insulin-receptor complex after the interaction of insulin with the corresponding receptor.

One of the sulfonylurea drugs of the second generation is Gliquidone (glurenorm). This drug has one advantage, distinguishing it from other sulfonylurea drugs. About 95% of the drug is excreted from the body through the gastrointestinal tract, and only 5% is extracted by the kidneys. Therefore, it is the drug of choice in the treatment of diabetic patients with nephropathy, given the fact that the drug is metabolized in the liver and eliminated through the bile ducts into the intestine. Naturally, the question arises of the possibility of its influence on the liver function of patients who have been receiving long-term treatment with glurenorm.
The combination of cystic thyroid changes with cystic changes in other organs
Authors: Murahovskaya E. V. , Katsova I. B.
Published: October 2019

The combination of cystic changes in the thyroid gland with a violation of its function with cystic changes in other organs is rare and is of practical interest. Thyroid dysfunction can be due to various causes. In the literature, there are a small number of observations of a combination of cystic changes in a number of organs, including the thyroid gland.

The literature describes the combination of congenital cysts of the lungs, kidneys, thyroid gland in a child of 11 months, who was diagnosed with polycystic left kidney and multiple thin-walled cavities in the lower pulmonary field. Left-sided nephrectomy was performed. In 3 years - left-sided hemistrumectomy for macrofollicular adenoma of the thyroid gland. In the dynamics of the patient there was an increase in the size of cysts in the lungs without clinical manifestation. In adults, such changes are not described. This article presents a case of cystic thyroid changes with hyperthyroidism combined with cystic liver and kidney changes.
The cerebral amygdaloid body: Functional morphology and neuroendocrinology
Authors: Kandror V. I. , Akmayev I. G. , Kalimullina L. B.
Published: October 2019

Due to the fact that endocrine functions are inherent in almost all areas of the brain, the hypothalamus ceases to be an exclusive object of research by neuroendocrinologists. An increasing number of brain regions are being drawn into the orbit of neuroendocrine research. Among them, the limbic region of the brain attracts the most attention, an important link of which, participating in the regulation of reproductive functions, is the amygdala complex (MC). Latest fundamental analysis, including structural, concerning histophysiologic and neuroendocrinological approaches are presented in the reviewed book. It must be admitted that the publication of this book is timely. Drawing on many years of experience of their own research and extensive literature, the authors analyze in detail the features of the structural organization of this region of the brain and the mechanisms of its interaction with the centers of the brain that control reproductive function. The book consists of a brief introduction, three main chapters and a conclusion. In addition to a large summary of the cited literature, attracts the attention of a rich and very illustrative material. The latter includes a volumetric reconstruction of the entire MC of the brain and its individual components, the reconstruction of the MC on a series of histological sections, each of which is further reproduced in the form of a schematic diagram, and finally, a series of the most informative sections of the MC, reflecting the main structures of this brain region on the frontal sections. Due to its uniqueness, the illustrative material can be used as an atlas of the structural organization of the MC, and therefore it is of independent value.
On diabetes mellitus register
Authors: Dedov I. I. , Suntsov Yu. I. , Kudryakova S. V. , Ryzhkov S. G.
Published: October 2019

The modern system of medical and statistical observation, which has developed in Russia, does not allow a sufficiently complete assessment of the real epidemiological situation in relation to such a disease as diabetes mellitus (DM). Meanwhile, the damage associated with the incidence of diabetes mellitus, early disability and mortality from it, as well as the cost of treatment of patients are very significant. Planning specialized care for patients, providing them with a sufficient amount of medicines, as well as training the necessary number of specialists and specially trained average staff to work with patients with diabetes requires a clear knowledge of their needs. In this regard, there is a need for a more complete and systematic account of not only the fact of disease or death, but also the presence of complications of diabetes, the need for insulin, oral hypoglycemic agents, the causes of disability and death of patients with diabetes. In world practice, the above problems are solved by creating a register of SD. In its modern view, the diabetes register is an automated information system for recording the results of continuous medical-statistical monitoring of diabetes incidence and mortality in connection with it. The system provides for monitoring of the patient from the moment of his inclusion in the register until his death. The latter involves the registration of information about the patient with diabetes in various aspects: the presence of complications, their dynamics, treatment and availability of drugs, as well as the nature of the course of diabetes, the direct causes of death of the patient. The amount of information recorded depends on the objectives pursued by the organizers of the register.
Modern concepts for the diagnosis and treatment of hypothyroidism
in adults
Authors: Fadeev V. V.
Published: October 2019

The relevance of the problem of hypothyroidism in the clinical practice of doctors of all specialties is not necessary. Hypothyroidism is one of the most common diseases of the endocrine system. According to some epidemiological studies, in certain population groups the prevalence of subclinical hypothyroidism reaches 10-12% [16]. In the last decade, a large number of works on the problem of hypothyroidism have appeared, which have transformed our views on the entire pathology of the thyroid gland (thyroid gland). This is primarily due to the introduction of modern thyroid hormone preparations into clinical practice.
Idiopathic hypoparathyroidism with epilepsy, optic atrophy and the syndrome of the "empty" Turkish saddle
Authors: Bondar' I. A. , Klimentov V. V. , Sorogina L. D.
Published: October 2019

Hypoparathyroidism is an endocrine disease caused by decreased secretion or action of parathyroid hormone (PTH). In the vast majority of cases, clinicians experience hypoparathyroidism resulting from damage or removal of the parathyroid glands during surgical interventions.
Impact of hypolipidemic therapy on carbohydrate and lipid metabolism and their hormonal regulators in patients with type diabetes mellitus
Authors: Starkova N. T. , Dolgov V. V. , Davydov A. L. , Roitman A. P. , Baranova L. Yu. , Trubnikova T. Yu. , Sazhin N. L.
Published: October 2019

The effects of lipostat and maninil on carbohydrate and lipid metabolisms and their hormonal regulators were studied in 36 obese patients aged 50- 70 years who had type 2 diabetes mellitus concurrent with dyslipidemia. A course of therapy with lipostat in a daily dose of 20 mg for 3 months was shown to lead to nor­malization of lipid metabolism, to diminished glycemia and hy- perinsulinemia, and to an increase in fasting plasma somatotrop­ic hormone levels to normal values, these were not observed in the control group.
Expression of 5’-deiodinase in various thyroid tumors
Authors: Artykbaeva G. M. , Turakulov Ya. Kh
Published: October 2019

5'-deiodination is an important pathway for the metabolism of T4 by determining its great role as a prohormone for T3. T4 is metabolized by two 5'-deiodinases: DI and DII which are encoded by different genes, regulated by different modes and expressed in various tissues. The aim of the present study was to examine DI and DII expression in health and in various human thyroid tumors. Eighteen thyroid specimens (10 from tumors and 8 from the intact thyroid tissues surrounding the nodes) were used. RNA isolated from the tissues by reserve transcription, followed by polymerase chain reaction (PCR) were transcribed to cDNA. Gel electrophoresis showed the bands corresponding to 177 b. p for DI and 796 b. p for DII. The experiments demonstrated that there were genes of both isoenzymes of 5 ’deiodinases in thyroid carcinoma tissues. Gel electrophoresis indicated the different expression of PCR products in different thyroid tumors for DI and DII at the level of mRNA.
The effect of multiple injections of cholecystokinin 26-33 on a - and p-cells of islets of Langerhans normal and in experimental type 1 diabetes mellitus
Authors: Orlovskii M. A. , Kolesnik Yu. M. , Abramov A. V.
Published: October 2019

The impact of multiple peripheral (intraperitoneal) and central (intracerebroventricular) administrations of cholecystokinin 26-33 (CCK-8) octapeptide on the function of a- and /3- cells of the islets of Langerhans was studied in investigations made on normal rats and rats with experimental streptosotocine-induced type 1 diabetes mellitus. Insulin in /З-cells and glucagon in а-cells were found by indirect immunofluorescence. Both routes of administration to normal animals were shown to lead to the suppressed secretion of insulin with decreased food intake. At the same time the central administration of CCK-8, unlike the peripheral one, caused a sig­nificant (p < 0.05) rise in the level of glycemia and enhanced glucagon production in а-cells, while the administrations of the peptide to diabetic animals resulted a significant increase in the blood concentration of insulin (p < 0.05), to the lower level of glycemia (p < 0.05) and to suppressed polyphagia (p < 0.01), which is associated with the activation of /З-cell function and with the suppression of the pathologically high activity of а-cells. The established facts suggest that neuroendocrine interactions are impaired in diabetes mellitus and confirm the previously made suggestions that cholecystokinin plays an important role in the pathogenesis of this disease.
Disorders of lipid metabolism in subclinical hypothyroidism
Authors: Sych Yu. P. , Fadeev V. V. , Mel'nichenko G. A. , Syrkin A. L. , Roitman A. P.
Published: October 2019

Subclinical hypothyroidism (SG) is a syndrome caused by a persistent borderline decrease in the level of thyroid hormones in the body, in which a normal level of T4 is determined in combination with a moderately elevated level of TSH. SG is the most common thyroid dysfunction.
Incidence of diffuse toxic goiter in children irradiated as a result of the Chernobyl accident
Authors: Shilin D. E.
Published: October 2019

Time course of incidence of diffuse toxic goiter (DTG) was studied in 1986-1999 in the cohort of subjects who were aged under 15 years in the year of the Chernobyl accident and lived at radionuclide contaminated iodine deficient territories of Central Russia (Belgorod, Voronezh, and Orel regions, a total of 34 territories, n = 215,294). Control cohort (3-fold more numerous) consisted of age-matched residents of the same region, but from non-contaminated territories (45 territories, n = 665,987). During 5 years after the accident the morbidity was the same in both groups and lower than in children of Europe, Americas, Asia living in regions with normal and excess iodine consumption (0.279 per 100,000 annually in the main cohort and 0.390 in the control vs. 3-4 in foreign countries). The values remained low during subsequent 4 years (0.697 and 0.526 - the increases are insignificant). During recent 5 years the incidence of DTG sharply increased at all territories, most drastically in the cohort of irradiated subjects (1.579 and 0.841). The morbidity increased 2- fold in the control vs. the initial level (the relative risk being 2.1 (1.1-4. l,p < 0.03) and almost 6-fold in the main cohort (relative risk = 5.7 (1.7-19.3, p < 0.004). On the whole, 10-15 years after the accident, the risk of DTG for children exposed to low-intensive radiation surpassed the estimated level 1.9 times ([1.1-3.4], p < 0.04).
Chorionic gonadotropin regulation of intracellular potassium levels in human blood immunocompetent cells, a role of phases of a menstrual cycle
Authors: Shirshev S. V. , Lyalina O. G.
Published: October 2019

The effect of chorionic gonadotropin (CG) on intracellular po­tassium ion( [K+]) levels in human blood immunocompetent cells was studied by taking into account the phases of a menstrual cy­cle. CG was used in doses of 10, 50, and 100 IU/ml. Plasma photometry was used to measure the level of [K+] ‘ in the frac­tionated peripheral monocytes and lymphocytes from males, as well as from females in the late follicular and luteal phases of a menstrual cycle. CG used in a dose of 100 IU/ml was found to lower flCf in the monocytes and lymphocytes of males and in a dose of 50 IU in the lymphocytes of females in the luteal phase of a menstrual cycle. The hormone used in large doses stabilized the level of [K+] in both types of cell of female in the follicular phase. It is concluded that CG can modulate the level of [K+] in human peripheral blood immunocompetent cells, and the direc­tionality of its effects depends on a type of hormone-accepting cells and it is determined by a menstrual phase.
Natalya V. Repkina - Experimento genético-modelador e a produção do sistema Elkonin-Davidov-Repkin: um olhar para os processos experimentais do ensino desenvolvimental
Authors: Longarezi Andréa Maturano
Published: October 2019

Natalya V. Repkina é graduada em Psicologia e doutora em Ciências Psicológicas (1987). Professora do Departamento de Psicologia da Universidade Estatal de Kharkov (1972-1977). Desde 1990 é docente do Departamento de Psicologia da Universidade Nacional de Shevchenko, na cidade de Lugansk, Ucrânia. Entre 1997 e 2004 ocupou a chefia do Departamento de Psicologia e Pedagogia do Instituto Siberiano de Ensino Desenvolvimental de Tomsk. É uma das principais representantes do sistema Elkonin-Davidov na Ucrânia. É autora de numerosos livros e artigos científicos sobre ensino desenvolvimental, especialmente, sobre Atividade de Estudo e Diagnóstico da Atividade de Estudo.
Ensino Desenvolvimental em Ciências Humanas: ações didáticas orientadoras do trabalho docente
Authors: Souza Leandro Montandon de Araújo
Published: October 2019

Este trabalho compõe um conjunto de esforços coletivos que visam a instrumentalização teórica do Ensino Desenvolvimental, materializadas em práticas de ensino verificadas na realidade da sala de aula e que tenham apresentado resultados promissores. Nosso objetivo é que possam servir de apoio e orientação a outras práticas que também compartilhem das intencionalidades formativas que marcam o pensamento Histórico-Cultural, mais precisamente, o desenvolvimento humano, de habilidades psicológicas superiores e, em especial, da formação do conceito e do pensamento conceitual. Com esta orientação principal, buscamos instrumentalizar algumas ações didáticas que possam contribuir com o ensino de Ciências Humanas, a adolescentes do Ensino Médio e orientadas nas bases epistemológicas da Teoria Histórico-Cultural.
O conteúdo filosófico e o sujeito da aprendizagem: aportes para a organização do ensino de Filosofia em nível médio
Authors: Belieri Cleder Mariano , Sforni Marta Sueli de Faria
Published: October 2019

Pesquisas já realizadas pelo Grupo de Estudos e Pesquisas sobre Atividade de Ensino (GEPAE) têm evidenciado que o planejamento de ensino que visa o desenvolvimento dos estudantes deve ter como ponto de partida a análise do objeto de ensino e do sujeito da aprendizagem. Neste artigo, analisamos o objeto de ensino - o conceito filosófico- e o sujeito da aprendizagem do ensino médio - o adolescente. Por meio dessa análise, evidenciamos a relação entre as características desse período do desenvolvimento humano e o conhecimento filosófico, bem como identificamos algumas ações didáticas que procuram aproximar os motivos de ensinar filosofia aos motivos de aprendizagem dos estudantes.
Didática desenvolvimental e as necessárias reelaborações dos currículos para o ensino de história
Authors: Soares Olavo Pereira
Published: October 2019

O artigo tem por objetivo identificar as contribuições que os pressupostos teóricos e metodológicos da didática desenvolvimental Â nos fornecem para análise dos currículos para o ensino de história. Tais contribuições incidem tanto sobre a prescrição quanto ao praticado e nos encaminham para a necessária revisão das concepções sobre as aprendizagens presentes nas atuais propostas curriculares para o ensino da disciplina. Apresentamos dados que foram coletados em pesquisa-ação de caráter colaborativo realizada em escola pública. Tais dados demonstram que as atuais prescrições curriculares dificultam a efetivação de uma prática curricular que possibilite a pesquisa, a produção do conhecimento e o desenvolvimento do pensamento teórico por parte dos escolares. Não obstante, os mesmos dados nos possibilita propor modificações nos currículos praticados nas escolas.
Technology-supported global education: A mixed method study
Authors: Egüz Şule , Öztürk Cemil , Kesten Alper
Published: October 2019

The purpose of this study was to investigate the effects of using communication technologies in teaching of attainments related to global education in social studies course on students’ academic success, knowledge retention and their opinions on teaching practice. The research was carried out on the 6th grade students in a secondary school in the province of Samsun. In the research, exploratory order model, one of the mixed method research designs, was used. There were 44 students in the experimental group and 41 students in the control group. “Academic achievement test" was used for data collection. The second phase of the study was designed as a case study and a semi-structured interview form was used to collect data. The interview form prepared for 10 students in the experimental group was applied. One-factor ANOVA was used for the repeated measures of the relationship between pre-test, post-test and retention scores of the experimental and control groups to determine the retention of the program in learning. Descriptive analysis method was used in the analysis of qualitative data. At the end of the research, it was found that the technology supported teaching program applied to the experimental group was more effective in increasing students' academic achievement and learning retention compared to the teaching application in the control group which was not supported by communication technologies and where teacher-centered teaching -straight expression method- was used.
Staurochilus ramosus (Lindl.) Seidenf (Orchidaceae): an addition to the flora of Tripura
Authors: Baishnab Biswajit , Chowdhury Ashish Kumar , Datta Badal Kumar
Published: October 2019

In this study we have included a monopodial epiphytic orchid, Staurochilus ramosus (Lindl.) Seidenf. to the flora of Tripura, for the first time. This article deals with a little bit of genus description, geographical location, phenology and taxonomic enumeration supported by suitable photo flyer.
Drought stress in plants: An overview on implications, tolerance mechanisms and agronomic mitigation strategies
Authors: Hussain Sadam , Hussain Saddam , Qadir Tauqeer , Khaliq Abdul , Ashraf Umair , Parveen Abida , Saqib Muhammad , Rafiq Muhammad
Published: October 2019

Drought is considered as one of the major limiting factors affecting growth and productivity of crop plants. It severely affects the morphological and physiological activities of the plants and hampers the seed germination, root proliferation, biomass accumulation and final yield of field crops. Drought stress disrupts the biosynthesis of chlorophyll contents, carotene and decreases photosynthesis in plants. It gradually reduces CO2 assimilation rates owing to decrease in stomatal conductance. In addition, drought affects cell membrane stability and disrupts water relations of a plant by reducing water use efficiency. To cope with these situations, plants adopt different mechanisms such as drought tolerance, avoidance and escape. In this review, we discussed about the effects of drought on morphological and physiological characteristics of plants and suggested the different agronomic practices to overcome the deleterious effects of drought stress.
Notes on the typification of three names in Indian Ranunculus L. (Ranunculaceae)
Authors: Kumar Anand , Maurya Onkar Nath
Published: October 2019

The erroneous designation of holotype and lectotype of three names in Ranunculus namely R. reniformis Wall. ex Wight & Arn., R. subpinnatus Wight & Arn. and R. wallichianus Wight & Arn. in one of the recent publications is discussed here. This paper also emphasizes the precise application of the phrase typification of the name and also rectifies here the erroneous designation of holotype and lectotype of names in a recent publication.
Diverse application and future prospects for commercial cultivation of microalgae species: A review
Authors: Sharma Nishesh , Singh Ajay , Lalremruati Felicia , Vanlalmalsawmi _ , Sharma Rohit
Published: October 2019

Industrial revolutions, advancements in health care, pharmaceuticals, transportation can be attributed to advancements made in the field of science and technology. Environment and natural resources has paid a heavy cost for most of industrial development. Rapid depletion of non-renewable sources of energy eventually leading towards the energy crisis, direct or indirect release of industrial effluents into soil and natural water bodies, global warming are among major consequences of industrialization. Ever since these environmental concerns have been recognized substantial studies have been conducted to minimize, control pollution and restore environment and natural resources. Among several measures cultivation of algae on large scale stands out to be a multipurpose solution. Inherent potential of microalgae species to accumulate lipids makes algae an efficient source of biofuel. Beside this ability of algae to detoxify polluted water and industrial effluent support utilization of algae for environment management and restoration. Efficient CO2 fixation, ability to tolerate wide range of environmental conditions, minimal nutritional requirements further support commercial cultivation of algal species to achieve their widespread application. However, efforts are required to develop large scale cultivation protocols (beyond the range of photobioreactors) so as to achieve practical applicability of algae and their products. Alongwith, cultivation protocols there is simultaneous need of either selection of naturally occurring high yielding strains / species or genetic improvement. Standardization of optimum cultivation conditions along with harvesting procedure is equally important.
Peat moss: A hyper-sorbent for oil spill cleanup - a review
Authors: Pandey Saumya , Alam Afroz
Published: October 2019

Peat moss, a well-known hyper-sorbent is now gaining attention for its utilization in oil-spill cleanup techniques because of its cost-effectiveness, biodegradability and relatively high oil absorption capacities. This review mainly emphasis on the characteristic features of the peat moss such as high porosity and large surface area which make it an efficient natural sorbent material for cleaning up oil spills. There are several products which have been developed from the peat moss and are commercially available in the market for oil spill cleanup.
A review on molecular techniques employed for authentication of Indian medicinal plants
Authors: Mattummal Rubeena , Kallingilkalathil Gopi Divya , Bobbili Erni , Koppala Narayana Sunil Kumar
Published: October 2019

Traditional medical systems are advancing to the level of modern medicines in treatment and preventive aspects. The increased trade in medicinal plants provides income source for herbalists while substitution of rare ingredients with cheaper and more readily available species is misleading the end users. The prime cause of the problems associated with the standardization of medicinal plants is complex composition of herbal drugs used in the form of whole plants, plant parts or extracts. Deliberate adulteration of intended ingredients are posing difficulty in distinguishing the genuine resources. Authentication of medicinal plants by recent molecular techniques is inevitable for herbal drug industries, researchers and academia. Of late, herbal genomics, molecular studies of medicinal plants and powerful next generation sequencing techniques have been emerged to transform the current knowledge. A compilation of various molecular markers used, their efficiency in barcoding for the purpose of accurate authentication of herbal drugs has been attempted in this study. Data were collected from previous literature and online repositories like NCBI, Pubmed etc. There are various molecular techniques that can be exploited for authentication of medicinal plants such as Restriction Fragment Length Polymorphism (RFLP), Random Amplified Polymorphic DNA (RAPD), Amplified Fragment Length Polymorphism (AFLP), Sequence Characterized Amplified Region (SCAR), Selective Amplification of Microsatellite polymorphic loci (SAMPL), Simple Sequence Repeats (SSR), Inter Simple Sequence Repeat (ISSR), DNA barcoding, Next Generation Sequencing Techniques etc. Some of medicinal plants were reported having molecular data useful in plant identification. The genomic data of poly herbal formulations helps for scientific validation and universal recognition. Even though the challenges associated with reprehensibility, primer designing, amplification products of molecular markers and troubles related with DNA isolation and purification, become the major obstacle in front of researchers. It is high time to focus these novel strategies for proper identification to ensure the fidelity of traditional herbal products and there by promoting a step towards the global acceptance of our indigenous medicinal systems.
Józef Tymanowski, Rola i znaczenie Republiki Białoruś we współczesnej Europie, Wydawnictwo Adam Marszałek, Toruń 2017, ss. 245.
Authors: Czachor Rafał
Published: October 2019

Recenzja
O patriotyzmie Wielkopolskim – ze spuścizny regionalizmu wielkopolskiego XIX/XX wieku
Authors: Kowalczyk Ryszard
Published: October 2019

Autor skupił się na próbie zdefiniowania idei patriotyzmu wielkopolskiego, korzystając z dorobku nauki, literatury i czasopiśmiennictwa XIX/XX wieku, głównie z Wielkopolski. Osadził pojęcie patriotyzmu Wielkopolan na tle idei regionalizmu, w szczególności regionalizmu wielkopolskiego, którego podstawy programowe i praktyka w warunkach zaboru pruskiego były specyficzne dla tego regionu.
The European Union’s strategy on Afghanistan. Selected Issues
Authors: Sabawoon Mirza
Published: October 2019

Zamach na World Trade Center z 11 września 2001 roku był dowodem na zwiększające się zagrożenie terrorystyczne dla USA, ale również dla Unii Europejskiej. Nie dziwi zatem, że UE zaczęła walczyć z terroryzmem również poza jej własnym obszarem. Afganistan stanowił na tyle duże zagrożenie, że wspólnota europejska zdecydowała się na czynny udział najpierw w wojnie z talibami, a następnie w misji pokojowej na tamtym terenie. Artykuł pozwala prześledzić ewolucję zaangażowania Unii Europejskiej w pomoc Afganistanowi, w sprawę demokratyzacji, odbudowy kraju i jego struktur, stworzenia społeczeństwa obywatelskiego oraz poprawę jakości życia. Pochylono się też nad zapisami najnowszej strategii UE dla Afganistanu z 2017 roku, która najsilniejszy nacisk kładzie na kwestie przestrzegania praw człowieka, zwiększenia roli kobiet w życiu społecznym oraz zapewnieniu pokoju i stabilności w regionie.
Fractional Choquard Equations with Confining Potential With or Without Subcritical Perturbations
Authors: Mugnai Dimitri , Proietti Lippi Edoardo
Published: October 2019

In this paper, we consider fractional Choquard equations with confining potentials. First, we show that they admit a positive ground state and infinitely many bound states. Then we prove the existence of two signed solutions when a superlinear and subcritical perturbation is added; in this case, the main feature is that such a perturbation does not satisfy the usual Ambrosetti–Rabinowitz condition.
Die Juden im Decretum Gratiani
Authors: Friedrich Lotter
Published: October 2019

Although it never entered the Church’s official legal code, the Decretum Gratiani, completed around 1140, systematically summarizes a millennium of ecclesiastical legislature and therefore forms the basis of later canonistic teachings. This applies also to the numerous clauses it contains relating to Jews and Christian-Jewish co-existence. Besides the specific articles that explicitly refer to Jews, importance must be assigned to numerous others which, though they do not expressly name Jews, relate equally to them, and have scarcely been considered in previous analyses. In fact, historical research has also overlooked many of the articles explicitly concerned with Jews. The number of relevant edicts presented in this essay is therefore more than twice that of previous compilations. This extensive material is systematically compiled in groupings: toleration, acknowledgement and legal protection for Jews; efforts at conversion, Christian-Jewish intermarriages, children and slaves of Jews; prevention of proselytising and the apostasy of converts; theological disavowal, rights limitation and suppression of the Jews. In conclusion, the significance of the Decretum Gratiani for the treatment of Jews is examined in comparison with other canonistic collections of the High Middle Ages, and is found to be relatively moderate. The appended tables not only provide a systematic overview of the relevant articles, but also list their origin, and their appearance in the more important pre-Gratian canonical collections.