bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of Intravenous Dexamethasone Dose on the Occurrence of Rebound Pain after Axillary Plexus Block in Ambulatory Surgery
Authors: Touil Nassim , Pavlopoulou Athanassia , Delande Simon , Geradon Pierre , Barbier Olivier , Libouton Xavier , Lavand’homme Patricia
Published: June 2023

Rebound pain (RP) remains a challenge in ambulatory surgery, characterized by severe pain upon resolution of a peripheral nerve block (PNB). Intravenous (IV) administration of Dexamethasone (DEXA) potentiates PNB analgesic effect and reduces RP incidence although preventive effective dose remains undetermined. This retrospective analysis evaluates the preventive effect of IV DEXA on RP in outpatients undergoing upper limb surgery under axillary block. DEXA was divided into high (HD > 0.1 mg/kg) or low (LD < 0.1 mg/kg) doses. RP was defined as severe pain (NRS ≥ 7/10) within 24 h of PNB resolution. DEXA HD and LD patients were matched with control patients without DEXA (n = 55) from a previous randomized controlled study. Records of 118 DEXA patients were analyzed (DEXA dose ranged from 0.05 to 0.12 mg/kg). Intraoperative IV DEXA was associated with a significant reduction of the pain felt when PNB wore off as well as to a significant reduction of RP incidence (n = 27/118, 23% vs. 47% in controls, p = 0.002) with no effect related to the dose administered (p = 0.053). Our results support the administration of intraoperative DEXA as a preventive measure to reduce the occurrence of RP.
Validation of the Polish Version of Knee Outcome Survey Activities of the Daily Living Scale in a Group of Patients after Arthroscopic Anterior Cruciate Ligament Reconstruction
Authors: Szczepanik Magdalena , Jabłoński Jarosław , Bejer Agnieszka , Bazarnik-Mucha Katarzyna , Majewska Joanna , Snela Sławomir , Szymczyk Daniel
Published: June 2023

Background: The study aimed to assess the reliability, validity, and responsiveness of the Polish version of Knee Outcome Survey Activities of the Daily Living Scale (KOS-ADLS) in a group of patients after arthroscopic reconstruction of the anterior cruciate ligament (ACL). Methods: The study was a longitudinal study with repeated measures. One hundred and twelve subjects who qualified for arthroscopic ACL reconstruction (mean age = 31.8 years) were initially enrolled in this study. The Polish version of KOS-ADLS and Short Form-36 v. 2.0 (SF-36) were used. Results: The Polish version of KOS-ADLS in subjects after ACL rupture demonstrated excellent internal consistency (Cronbach’s alpha for KOS-ADLS- total = 0.91), and test–retest reliability using the intraclass correlation coefficient (ICC-total = 0.98). The standard error of measurement (SEM) value was 0.81 and the minimal detectable change (MDC) was 2.23 for KOS-ADLS-total. The validity analysis showed a moderate and low correlation between KOS-ADLS and different domains of SF-36 from r = 0.354 between KOS-ADLS activity and the physical component scale (PCS) of SF-36: to r = 0.206 between KOS-ADLS activity and the mental component scale (MCS) of SF-36. Conclusions: The Polish version of KOS-ADLS turned out to be a reliable, valid and responsive self-reported outcome measure, allowing for the self-assessment of symptoms and function related to the knee joint impairment after ACL reconstruction. Therefore, the scale can be applied in clinical practice and research.
Marginal Ulcers after Roux-en-Y Gastric Bypass: Etiology, Diagnosis, and Management
Authors: Salame Marita , Jawhar Noura , Belluzzi Amanda , Al-Kordi Mohammad , Storm Andrew C. , Abu Dayyeh Barham K. , Ghanem Omar M.
Published: June 2023

Marginal ulcer (MU) is a potential complication following Roux-en-Y gastric bypass (RYGB), with a mean prevalence of 4.6%. Early identification and prompt intervention are crucial to mitigating further complications. The pathophysiology of MU is complex and involves multiple factors, including smoking, Helicobacter pylori infection, non-steroidal anti-inflammatory drug (NSAID) use, and larger pouch size. Patients with MU may experience acute or chronic abdominal pain. Rarely, they may present with a complication from the ulceration, such as bleeding, perforation, or strictures. Following diagnosis by endoscopy, management of MU typically involves modification of risk factors and medical therapy focused on proton pump inhibitors. In case of complicated ulcers, surgical intervention is often required for the repair of the perforation or resection of the stricture. For recurrent or recalcitrant ulcers, endoscopic coverage of the ulcer bed, resection of the anastomosis, and abdominal or thoracoscopic truncal vagotomy may be considered. This review aims at providing an overview of the etiology, diagnosis, and management of MU after RYGB.
Automated Vehicle Counting from Pre-Recorded Video Using You Only Look Once (YOLO) Object Detection Model
Authors: Majumder Mishuk , Wilmot Chester
Published: June 2023

Different techniques are being applied for automated vehicle counting from video footage, which is a significant subject of interest to many researchers. In this context, the You Only Look Once (YOLO) object detection model, which has been developed recently, has emerged as a promising tool. In terms of accuracy and flexible interval counting, the adequacy of existing research on employing the model for vehicle counting from video footage is unlikely sufficient. The present study endeavors to develop computer algorithms for automated traffic counting from pre-recorded videos using the YOLO model with flexible interval counting. The study involves the development of algorithms aimed at detecting, tracking, and counting vehicles from pre-recorded videos. The YOLO model was applied in TensorFlow API with the assistance of OpenCV. The developed algorithms implement the YOLO model for counting vehicles in two-way directions in an efficient way. The accuracy of the automated counting was evaluated compared to the manual counts, and was found to be about 90 percent. The accuracy comparison also shows that the error of automated counting consistently occurs due to undercounting from unsuitable videos. In addition, a benefit–cost (B/C) analysis shows that implementing the automated counting method returns 1.76 times the investment.
Evaluation of Soil–Foundation–Structure Interaction for Large Diameter Monopile Foundation Focusing on Lateral Cyclic Loading
Authors: Kim Jae-Hyun , Jeong Yeong-Hoon , Ha Jeong-Gon , Park Heon-Joon
Published: June 2023

In this study, the monotonic and cyclic behavior of an offshore wind turbine with a monopile foundation installed in a sand layer were evaluated in the centrifuge. A simplified offshore wind turbine was modeled, and the lateral load was applied to the tower under displacement control. The monotonic loading test evaluated ultimate lateral load capacity and bending moment profiles under different loading levels. During cyclic loading, variations of moment-rotation responses, cyclic stiffness, and bending moments along the pile were observed. The initial rotational stiffness of the monopile decreased as the loading level increased. In the fatigue limit state (FLS) and service limit state (SLS) loading conditions, no noticeable variation in stiffness was observed with the number of cycles. However, in the ultimate limit state (ULS), the stiffness of the monopile increased during the first few cycles, followed by a decreasing rate of increase, and reached a certain value. The loading rate had a weakening effect on the monopile–soil interaction, which was supported by the bending moments induced in the monopile.
Determination of Loading and Residual Stresses on Offshore Jacket Structures by X-ray Diffraction
Authors: Schubnell Jan , Carl Eva , Widerspan Viktor , Collmann Mareike
Published: June 2023

As basements of offshore wind turbines (OWTs) in deep water (>50 m), jacket structures are an economic alternative to monopiles. For this reason, the structural durability of jackets has become more important. In such structures, welded tubular joints are weak points for fatigue design. The harmful effect of tensile residual stresses in welding joints is well known. For these reasons, the residual stresses and the loading stresses of offshore jacket structures were determined by X-ray diffraction (XRD) using a mobile diffractometer. This allows us to directly determine the load stress at the fatigue-critical locations, namely at the weld toe at the testing rig. High tensile residual stresses up to 250 MPa were determined in a welded (and unloaded) condition. At a loaded structure (10,000 load cycles), a lower residual stress level was determined. During loading, a local increase in the stress at the welded joint that is between 1.4 and 4 times higher than the applied nominal stress was determined. Furthermore, it is shown that additional treatment (grinding and clean blasting) influences the local stress state significantly.
Arctic Route Planning and Navigation Strategy: The Perspective of Ship Fuel Costs and Carbon Emissions
Authors: Chen Aowen , Chen Weiqi , Zheng Jian
Published: June 2023

Arctic navigation research will be more urgent as it is predicted that 4.7% of the shipping trade will be deployed in the Arctic region by 2030. This paper presents a multi-objective path optimization algorithm based on the field theory to investigate Arctic shipping route design and navigation strategies that take safety, economy and environmental protection as factors. The algorithm considers the ice conditions in Arctic waters throughout the year, the energy consumption of ships with different ice classes and carbon emissions. The sea environment is initially modeled using the potential field method, incorporating the ice condition field, fuel consumption, emission field and directional field. The navigable area is defined based on the ship navigability, and path optimization is conducted using the principle of gradient descent between the departure point and destination. The experimental results show that the cost of carbon emissions and fuel consumption varies for each class of ship on the planned path in different months. Therefore, by combining different classes of ships and months, we obtain an Arctic navigation strategy with a consideration of the best cost and environmental protection for each month. The path planning and navigation strategy decision method proposed in this paper can provide a reference for an Arctic route design, navigation month and vessel selection, which is beneficial to the sustainable development of Arctic shipping.
Multi-Locus Phylogenetic Analysis Revealed the Association of Six Colletotrichum Species with Anthracnose Disease of Coffee (Coffea arabica L.) in Saudi Arabia
Authors: Alhudaib Khalid , Ismail Ahmed Mahmoud , Magistà Donato
Published: June 2023

Several Colletotrichum species are able to cause anthracnose disease in coffee (Coffea arabica L.) and occur in all coffee production areas worldwide. A planned investigation of coffee plantations was carried out in Southwest Saudi Arabia in October, November, and December 2022. Various patterns of symptoms were observed in all 23 surveyed coffee plantations due to unknown causal agents. Isolation from symptomatic fresh samples was performed on a PDA medium supplemented with streptomycin sulfate (300 mg L−1) and copper hydroxide (42.5 mg L−1). Twenty-seven pure isolates of Colletotrichum-like fungi were obtained using a spore suspension method. The taxonomic placements of Colletotrichum-like fungi were performed based on the sequence dataset of multi-loci of internal transcribed spacer region rDNA (ITS), chitin synthase I (CHS-1), glyceraldehyde-3-phosphate dehydrogenase (GAPDH), actin (ACT), β-tubulin (TUB2), and partial mating type (Mat1–2) (ApMat) genes. The novel species are described in detail, including comprehensive morphological characteristics and colored illustrations. The pathogenicity of the isolated Colletotrichum species was assessed on detached coffee leaves as well as green and red fruit under laboratory conditions. The multi-locus phylogenetic analyses of the six-loci, ITS, ACT, CHS-1, TUB2, GAPDH and ApMat, revealed that 25 isolates were allocated within the C. gloeosporioides complex, while the remaining two isolates were assigned to the C. boninense complex. Six species were recognized, four of them, C. aeschynomenes, C. siamense, C. phyllanthi, and C. karstii, had been previously described. Based on molecular analyses and morphological examination comparisons, C. saudianum and C. coffeae-arabicae represent novel members within the C. gloeosporioides complex. Pathogenicity investigation confirmed that the Colletotrichum species could induce disease in coffee leaves as well as green and red fruits with variations. Based on the available literature and research, this is the first documentation for C. aeschynomenes, C. siamense, C. karstii, C. phyllanthi, C. saudianum, and C. coffeae-arabicae to cause anthracnose on coffee in Saudi Arabia.
The Influence of Cone Age and Urbanisation on the Diversity and Community Composition of Culturable Seed Fungal Endophytes within Native Australian Banksia ericifolia L.f. subsp. ericifolia
Authors: Philpott Merize , Liew Edward C. Y. , van der Merwe Marlien M. , Mertin Allison , French Kristine
Published: June 2023

Seed fungal endophytes play a crucial role in assisting the overall health and success of their host plant; however, little is known about the factors that influence the diversity and composition of these endophytes, particularly with respect to how they change over time and within urban environments. Using culturing techniques, morphological analyses, and Sanger sequencing, we identified the culturable seed fungal endophytes of Banksia ericifolia at two urban and two natural sites in Sydney, New South Wales, Australia. A total of 27 Operational Taxonomic Units were obtained from 1200 seeds. Older cones were found to contain, on average, more colonised endophytes than younger cones. Species richness was also significantly influenced by cone age, with older cones being more speciose. Between urban and natural sites, the overall community composition did not change, although species richness and diversity were greatest at urban sites. Understanding how these endophytes vary in time and space may help provide an insight into the transmission pathways used and the potential role they play within the development and survival of the seed. This knowledge may also be crucial for restoration purposes, especially regarding the need to consider endophyte viability in ex situ seed collection and storage in seed-banking practices.
Persistent Symptoms and IFN-γ-Mediated Pathways after COVID-19
Authors: Piater Talia , Gietl Mario , Hofer Stefanie , Gostner Johanna M. , Sahanic Sabina , Tancevski Ivan , Sonnweber Thomas , Pizzini Alex , Egger Alexander , Schennach Harald , Loeffler-Ragg Judith , Weiss Guenter , Kurz Katharina
Published: June 2023

After COVID-19, patients have reported various complaints such as fatigue, neurological symptoms, and insomnia. Immune-mediated changes in amino acid metabolism might contribute to the development of these symptoms. Patients who had had acute, PCR-confirmed COVID-19 infection about 60 days earlier were recruited within the scope of the prospective CovILD study. We determined the inflammatory parameters and alterations in tryptophan and phenylalanine metabolism in 142 patients cross-sectionally. Symptom persistence (pain, gastrointestinal symptoms, anosmia, sleep disturbance, and neurological symptoms) and patients’ physical levels of functioning were recorded. Symptoms improved in many patients after acute COVID-19 (n = 73, 51.4%). Still, a high percentage of patients had complaints, and women were affected more often. In many patients, ongoing immune activation (as indicated by high neopterin and CRP concentrations) and enhanced tryptophan catabolism were found. A higher phenylalanine to tyrosine ratio (Phe/Tyr) was found in women with a lower level of functioning. Patients who reported improvements in pain had lower Phe/Tyr ratios, while patients with improved gastrointestinal symptoms presented with higher tryptophan and kynurenine values. Our results suggest that women have persistent symptoms after COVID-19 more often than men. In addition, the physical level of functioning and the improvements in certain symptoms appear to be associated with immune-mediated changes in amino acid metabolism.
Complications of Pessaries Amenable to Surgical Correction: Two Case Reports and a Systematic Review of the Literature
Authors: Calles Sastre Laura , Almoguera Pérez-Cejuela Belén , Pereira Sánchez Augusto , Herrero Gámiz Sofía , Magrina Javier F. , Ríos Vallejo Mar , Pérez Medina Tirso
Published: June 2023

Background: Forty percent of women will experience prolapse in their lifetime. Vaginal pessaries are considered the first line of treatment in selected patients. Major complications of vaginal pessaries rarely occur. Methods: PubMed and Embase were searched from 1961 to 2022 for major complications of vaginal pessaries using Medical Subject Headings (MeSH) and free-text terms. The keywords were pessary or pessaries and: vaginal discharge, incontinence, entrapment, urinary infections, fistula, complications, and vaginal infection. The exclusion criteria were other languages than English, pregnancy, complications without a prior history of pessary placement, pessaries unregistered for clinical practice (herbal pessaries), or male patients. The extracted data included symptoms, findings upon examination, infection, type of complication, extragenital symptoms, and treatment. Results: We identified 1874 abstracts and full text articles; 54 were assessed for eligibility and 49 met the inclusion criteria. These 49 studies included data from 66 patients with pessary complications amenable to surgical correction. Clavien–Dindo classification was used to grade the complications. Most patients presented with vaginal symptoms such as bleeding, discharge, or ulceration. The most frequent complications were pessary incarceration and fistulas. Surgical treatment included removal of the pessary under local or general anesthesia, fistula repair, hysterectomy and vaginal repair, and the management of bleeding. Conclusions: Pessaries are a reasonable and durable treatment for pelvic organ prolapse. Complications are rare. Routine follow-ups are necessary. The ideal patient candidate must be able to remove and reintroduce their pessary on a regular basis; if not, this must be performed by a healthcare worker at regular intervals.
Protective Effects of Cirsium japonicum var. maackii Flower on Amyloid Beta25–35-Treated C6 Glial Cells
Authors: Pang Qi Qi , Lee Sanghyun , Cho Eun Ju , Kim Ji-Hyun
Published: June 2023

Amyloid beta (Aβ) is a neurotoxic peptide and a key factor causing Alzheimer’s disease. Cirsium japonicum var. maackii (CJM) has neuroprotective effects, but the protective effects of the flower from CJM (FCJM) on the neural system remain unclear. This study aimed to identify the fraction of FCJM with the highest neuroprotective potential and investigate its protective mechanisms against Aβ25–35-induced inflammation in C6 glial cells. The cell viability and generation of reactive oxygen species (ROS) were measured to investigate the positive effect of FCJM on oxidative stress. Treatment with the FCJM extract or fractions increased the cell viability to 60–70% compared with 52% in the Aβ25–35-treated control group and decreased ROS production to 84% compared with 100% in the control group. The ethyl acetate fraction of FCJM (EFCJM) was the most effective among all the extracts and fractions. We analyzed the protective mechanisms of EFCJM on Aβ25–35-induced inflammation in C6 glial cells using Western blot. EFCJM downregulated amyloidogenic pathway-related proteins, such as Aβ precursor protein, β-secretase, presenilin 1, and presenilin 2. Moreover, EFCJM attenuated the Bax/Bcl-2 ratio, an index of apoptosis, and upregulated the oxidative stress-related protein, heme oxygenase-1. Therefore, this study demonstrated that FCJM improves cell viability and inhibits ROS in Aβ25–35-treated C6 glial cells. Furthermore, EFCJM exhibits neuroprotective effects in Aβ25–35-induced inflammation in C6 glial cells by modulating oxidative stress and amyloidogenic and apoptosis signaling pathways. FCJM, especially EFCJM, can be a promising agent for neurodegenerative disease prevention.
Therapy in the Course of Kidney Graft Rejection—Implications for the Cardiovascular System—A Systematic Review
Authors: Mizera Jakub , Pilch Justyna , Giordano Ugo , Krajewska Magdalena , Banasik Mirosław
Published: June 2023

Kidney graft failure is not a homogenous disease and the Banff classification distinguishes several types of graft rejection. The maintenance of a transplant and the treatment of its failure require specific medications and differ due to the underlying molecular mechanism. As a consequence, patients suffering from different rejection types will experience distinct side-effects upon therapy. The review is focused on comparing treatment regimens as well as presenting the latest insights into innovative therapeutic approaches in patients with an ongoing active ABMR, chronic active ABMR, chronic ABMR, acute TCMR, chronic active TCMR, borderline and mixed rejection. Furthermore, the profile of cardiovascular adverse effects in relation to the applied therapy was subjected to scrutiny. Lastly, a detailed assessment and comparison of different approaches were conducted in order to identify those that are the most and least detrimental for patients suffering from kidney graft failure.
Fabrication and Tribology Properties of Cr-Coated Cemented Carbide under Dry Friction Conditions
Authors: Zhang Li , Song Wenlong , An Lei , Xia Zixiang , Wang Shoujun , Li Tianya
Published: June 2023

To improve the surface friction characteristics of cemented carbide, a Cr coating was deposited on cemented carbide substrate with the multiple arc plating technique. The surface and cross-section micrographs, adhesion force and micro-hardness of the Cr-coated cemented carbide were tested. The anti-friction and anti-wear behaviors of cemented carbide with and without Cr coating were investigated via the sliding friction test against a WC/Co ball. The tribological properties of cemented carbide were examined using a scanning electron microscope and energy dispersive X-ray analysis. The test results showed that Cr-coated cemented carbide possessed good adhesion properties and lower hardness. The average coefficient of friction for Cr-coated cemented carbide was reduced by 10–20% compared with that of an uncoated one. The primary wear modes of the Cr-coated sample were delamination of coating, flaking and abrasion wear. It can be found that the preparation of a Cr coating is an effective way to enhance the friction and wear performance of traditional cemented carbide.
Microscopic Analysis of the Wetting Morphology and Interfacial Bonding Mechanism of Preoxidised Kovar Alloys with Borosilicate Glass
Authors: Shen Jiajia , Chen Changjun , Zhang Min
Published: June 2023

This paper investigates the wettability of Kovar alloys with high-borosilicate glass and microscopically analyses the mechanism of wettability and diffusion between Kovar and borosilicate glass. First, Kovar was oxidised at 800 °C for 5, 15, 25, 35, and 60 min to observe the oxide morphology of the Kovar surface layer and to analyse the composition of the oxide layer. To investigate the wetting pattern formations of Kovar and high-borosilicate glass under different wetting temperatures, times, and preoxidation conditions, Kovar and high-borosilicate glass obtained from different oxidation treatments were held at 1060 °C for 20 min for wetting experiments, and the glass–metal wetting interface morphology and elemental distribution were observed using SEM and EDS. The elemental diffusion at the wetting interface between the borosilicate glass and the Kovar with different preoxidation and at the glass spreading boundary was investigated. The longitudinal diffusion of the liquid glass in the metal oxide layer formed a new tight chemical bond of Fe2SiO4, and the lateral diffusion of the liquid glass in the Kovar surface layer formed a black halo.
CovC-ReDRNet: A Deep Learning Model for COVID-19 Classification
Authors: Zhu Hanruo , Zhu Ziquan , Wang Shuihua , Zhang Yudong
Published: June 2023

Since the COVID-19 pandemic outbreak, over 760 million confirmed cases and over 6.8 million deaths have been reported globally, according to the World Health Organization. While the SARS-CoV-2 virus carried by COVID-19 patients can be identified though the reverse transcription–polymerase chain reaction (RT-PCR) test with high accuracy, clinical misdiagnosis between COVID-19 and pneumonia patients remains a challenge. Therefore, we developed a novel CovC-ReDRNet model to distinguish COVID-19 patients from pneumonia patients as well as normal cases. ResNet-18 was introduced as the backbone model and tailored for the feature representation afterward. In our feature-based randomized neural network (RNN) framework, the feature representation automatically pairs with the deep random vector function link network (dRVFL) as the optimal classifier, producing a CovC-ReDRNet model for the classification task. Results based on five-fold cross-validation reveal that our method achieved 94.94%, 97.01%, 97.56%, 96.81%, and 95.84% MA sensitivity, MA specificity, MA accuracy, MA precision, and MA F1-score, respectively. Ablation studies evidence the superiority of ResNet-18 over different backbone networks, RNNs over traditional classifiers, and deep RNNs over shallow RNNs. Moreover, our proposed model achieved a better MA accuracy than the state-of-the-art (SOTA) methods, the highest score of which was 95.57%. To conclude, our CovC-ReDRNet model could be perceived as an advanced computer-aided diagnostic model with high speed and high accuracy for classifying and predicting COVID-19 diseases.
EV Charging Path Distribution Solution Based on Intelligent Network Connection
Authors: Wang Xinxin , Xu Qian , Shen Xiaopan
Published: June 2023

The long queuing time for electric vehicles to charge under intelligent network connection leads to low distribution efficiency. Therefore, this paper proposes a strategy to predict the probability of queues forming for electric vehicles arriving at charging stations under intelligent network connection. Both the dynamic demand of customers and the characteristics of the alternating influence of charging vehicles should be considered when studying such problems. Based on the above problem characteristics, a real-time dynamic charging selection strategy is developed by predicting the probability of other vehicles in the region going to the charging station. A distribution path optimization model based on intelligent network connection and queuing theory is proposed for electric logistics vehicles in charging mode, taking into account the time window constraint and the influence of charging vehicles when using intelligent network connection for path planning. The objective is to minimize the total cost, and the route for electric logistics vehicles is adjusted in real time. This is solved by an improved hybrid genetic-annealing algorithm. The experimental results show that this paper obtains real-time dynamic road information and charging information with the help of intelligent network connection. It predicts the queuing probability of electric vehicles by combining with queuing theory, which can help select a more suitable charging location and timing for electric logistics vehicles. This can effectively avoid peak periods and reduce waiting times. By comparing with other models, this paper’s model can save the distribution cost of electric vehicles.
Some Characteristic Properties of Non-Null Curves in Minkowski 3-Space 𝔼13
Authors: Almoneef Areej A. , Abdel-Baky Rashad A.
Published: June 2023

This paper gives new characteristic properties of non-null spherical and rectifying curves in Minkowski 3-space E13. In the light of the causal characteristics, we give some representations of rectifying non-null curves. Additionally, we proved that the tangential function of every non-null curve fulfills a third-order differential equation. Then, a number of well-known characteristic properties of rectifying, Lorentzian, and hyperbolic spherical curves are consequences of this differential equation.
Post-Quantum Signature Scheme Based on the Root Extraction Problem over Mihailova Subgroups of Braid Groups
Authors: Lin Hanling , Wang Xiaofeng , Li Min
Published: June 2023

In this paper, by introducing an isomorphism from the Mihailova subgroup of F2×F2 to the Mihailova subgroups of a braid group, we give an explicit presentation of Mihailova subgroups of a braid group. Hence, in a braid group, there are some Mihailova subgroups experiencing unsolvable subgroup membership problem. Based on this, we propose a post-quantum signature scheme of the Wang–Hu scheme, and we show that the signature scheme is free of quantum computational attack.
Inference Based on the Stochastic Expectation Maximization Algorithm in a Kumaraswamy Model with an Application to COVID-19 Cases in Chile
Authors: Figueroa-Zúñiga Jorge , Toledo Juan G. , Lagos-Alvarez Bernardo , Leiva Víctor , Navarrete Jean P.
Published: June 2023

Extensive research has been conducted on models that utilize the Kumaraswamy distribution to describe continuous variables with bounded support. In this study, we examine the trapezoidal Kumaraswamy model. Our objective is to propose a parameter estimation method for this model using the stochastic expectation maximization algorithm, which effectively tackles the challenges commonly encountered in the traditional expectation maximization algorithm. We then apply our results to the modeling of daily COVID-19 cases in Chile.
Production of a Reinforced Refractory Multielement Alloy via High-Energy Ball Milling and Spark Plasma Sintering
Authors: Menapace Cinzia , Shaik Khaja Naib Rasool , Emanuelli Lorena , Ischia Gloria
Published: June 2023

Refractory high entropy alloys have shown potential to be developed as structural materials for elevated temperature applications. In the present research, the multielement alloy Fe2TiVZrW0.5 was produced by high-energy ball milling of elemental powders in the air to promote the formation of reinforcing oxide and nitride particles followed by spark plasma sintering consolidation. The sintering temperature was optimized to achieve a full-density material that was characterized from the microstructural and mechanical points of view. Hardness and KIC were measured in the as-sintered condition as well as after thermal treatment at 1100 °C. TEM observations showed the presence of a fine distribution of ZrO2 and Ti(V)-N in the microstructure mainly constituted by the bcc Fe-V and Fe-V-W phases. The fine distribution of ceramic particles in a metallic multielement matrix is responsible for the consistent hardness and thermal stability of this alloy.
Clinical Blood Metabogram: Application to Overweight and Obese Patients
Authors: Lokhov Petr G. , Balashova Elena E. , Trifonova Oxana P. , Maslov Dmitry L. , Plotnikova Oksana A. , Sharafetdinov Khaider K. , Nikityuk Dmitry B. , Tutelyan Victor A. , Ponomarenko Elena A. , Archakov Alexander I.
Published: June 2023

Recently, the concept of a mass spectrometric blood metabogram was introduced, which allows the analysis of the blood metabolome in terms of the time, cost, and reproducibility of clinical laboratory tests. It was demonstrated that the components of the metabogram are related groups of the blood metabolites associated with humoral regulation; the metabolism of lipids, carbohydrates, and amines; lipid intake into the organism; and liver function, thereby providing clinically relevant information. The purpose of this work was to evaluate the relevance of using the metabogram in a disease. To do this, the metabogram was used to analyze patients with various degrees of metabolic alterations associated with obesity. The study involved 20 healthy individuals, 20 overweight individuals, and 60 individuals with class 1, 2, or 3 obesity. The results showed that the metabogram revealed obesity-associated metabolic alterations, including changes in the blood levels of steroids, amino acids, fatty acids, and phospholipids, which are consistent with the available scientific data to date. Therefore, the metabogram allows testing of metabolically unhealthy overweight or obese patients, providing both a general overview of their metabolic alterations and detailing their individual characteristics. It was concluded that the metabogram is an accurate and clinically applicable test for assessing an individual’s metabolic status in disease.
Beam Scanning and Capture of Micro Laser Communication Terminal Based on MEMS Micromirrors
Authors: Wang Xuan , Han Junfeng , Wang Chen , Xie Meilin , Liu Peng , Cao Yu , Jing Feng , Wang Fan , Su Yunhao , Meng Xiangsheng
Published: June 2023

With the development of space laser communication and the planned deployment of satellite Internet constellations, there is a growing demand for microminiature laser communication terminals. To meet the requirements of size, weight and power (SWaP), miniaturized terminals require smaller drive components to complete on-orbit scanning and capture, which must be fast and efficient to enable satellite laser communication networks. These miniaturized laser communication terminals are highly susceptible to the impact of the initial pointing accuracy of the laser beam and microvibrations of the satellite platform. Therefore, this paper proposes a laser scanning-capture model based on a Micro-electromechanical Systems (MEMS) micromirror that can provide a fast, large-scale scanning analysis. A scanning overlap factor is introduced to improve the capture probability under the influence of microvibrations. Finally, experimental analysis was carried out to verify the effectiveness of the proposed model, which can establish a theoretical basis for future ultra-long-distance microspace laser communication.
Velocity and Out-Step Frequencies for a Micro-Swimmer Based on Spiral Carbon Nanotubes
Authors: Zhang Ce , Ma Shiqi , Xu Lizhong
Published: June 2023

The existing producing processes of micro spiral swimmers are complex. Here, a microswimmer with a magnetic layer on the surface of the spiral carbon nanotubes is proposed, which has a simple producing process. For the microswimmer, its equations of the velocities and out-step frequency are deduced. Using these equations, the velocities and out-step frequency of the microswimmer and their changes with related parameters are investigated. Results show that its velocities are proportional to the radius and helix angle of the spiral carbon nanotubes, and its out-step frequencies are proportional to magnetic field strength, the helix angle and magnetic layer thicknesses of the spiral carbon nanotubes, and inversely proportional to the fluid viscosity. The out-step frequency of the microswimmer is measured, which is in good agreement with the calculative ones.
Acoustic Sensing of Fresh Feed Disturbances in a Locked-Cycle Laboratory AG/SAG Mill
Authors: Owusu Kwaku Boateng , Skinner William , Greet Christopher , Asamoah Richmond K.
Published: June 2023

In a large-scale operation, feed ores are introduced into the AG/SAG mill in a continuous mode at a given flow rate to replace the discharging slurry. Nonetheless, the variations in the feed characteristics, typically hardness and size distribution, could cause sudden disruption to the mill operation. This would be challenging to detect in practice, owing to the hostile environment of the mill. In this work, an acoustic sensing-based monitoring technique was utilized in a laboratory-scale AG/SAG mill locked-cycle study to keep track of fluctuations caused by feed ore heterogeneity. Analysis of the recorded mill acoustic response using statistical root mean square (RMS) and mill discharge sizes showed that the introduction of fresh feed with varying hardness and size distribution considerably altered the mill product undersize of −150 μm and acoustic emission. Overall, the acoustic sensing technique demonstrated that the AG/SAG mill stability as well as disturbances caused by different feed size fractions and hardness can be monitored using the mill acoustic response, an indication of real-time monitoring and optimisation.
Pharmacological Activity of Cepharanthine
Authors: Liu Ke , Hong Bixia , Wang Shuqi , Lou Fuxing , You Yecheng , Hu Ruolan , Shafqat Amna , Fan Huahao , Tong Yigang
Published: June 2023

Cepharanthine, a natural bisbenzylisoquinoline (BBIQ) alkaloid isolated from the plant Stephania Cephalantha Hayata, is the only bisbenzylisoquinoline alkaloid approved for human use and has been used in the clinic for more than 70 years. Cepharanthine has a variety of medicinal properties, including signaling pathway inhibitory activities, immunomodulatory activities, and antiviral activities. Recently, cepharanthine has been confirmed to greatly inhibit SARS-CoV-2 infection. Therefore, we aimed to describe the pharmacological properties and mechanisms of cepharanthine, mainly including antitumor, anti-inflammatory, anti-pathogen activities, inhibition of bone resorption, treatment of alopecia, treatment of snake bite, and other activities. At the same time, we analyzed and summarized the potential antiviral mechanism of cepharanthine and concluded that one of the most important anti-viral mechanisms of cepharanthine may be the stability of plasma membrane fluidity. Additionally, we explained its safety and bioavailability, which provides evidence for cepharanthine as a potential drug for the treatment of a variety of diseases. Finally, we further discuss the potential new clinical applications of cepharanthine and provide direction for its future development.
Pharmacological Modulation of Host Immunity with Hen Egg White Lysozyme (HEWL)—A Review
Authors: Bergamo Alberta , Sava Gianni
Published: June 2023

In the 100 years since its discovery, lysozyme has become an important molecule, both as model for studies in different fields and as a candidate for the therapy of various pathological conditions. Of the dozens of known lysozymes, in this review we focus on one in particular, lysozyme extracted from hen egg white (HEWL), and its interaction with the immune system when it is administered orally. Experimental data show that there is an axis that directs immune system activation from GALT (gut-associated lymphoid tissue) and the intestinal lymphocyte clusters. Although a contribution of peptidoglycans from digestion of the bacterial cell wall in the intestinal lumen cannot be excluded, immune stimulation is not dependent on the enzymatic activity of HEWL. The immune responses suggest that HEWL is able to recover from immunodepression caused by tumor growth or immunosuppressants, and that it also improves the success of chemotherapy. The positive results obtained in a small Phase 2 study in patients, the ease of oral administration of this protein, and the absence of adverse effects suggest that HEWL may play an important role in all diseases where the immune system is weakened or where its enhancement plays a critical role in the resolution of the pathology.
Recent Developments in Direct C–H Functionalization of Quinoxalin-2(1H)-Ones via Heterogeneous Catalysis Reactions
Authors: Yang Qiming , Wang Hu , Wang Xiang , Lei Yizhu
Published: June 2023

In recent years, Web of Science has published nearly one hundred reports per year on quinoxalin-2(1H)-ones, which have attracted great interest due to their wide applications in pharmaceutical and materials fields, especially in recyclable heterogeneous catalytic reactions for direct C–H functionalisation. This review summarises for the first time the methods and reaction mechanisms of heterogeneous catalytic reactions of quinoxalin-2(1H)-ones, including six major types of heterogeneous catalysts involved. The heterogeneous reactions of quinoxalin-2(1H)-ones are summarised by classifying different types of catalytic materials (graphitic phase carbon nitride, MOF, COF, ion exchange resin, piezoelectric materials, and microsphere catalysis). In addition, this review discusses the future development of heterogeneous catalytic reactions of quinoxalin-2(1H)-ones, including the construction of C-B/Si/P/RF/X/Se bonds by heterogeneous catalytic reactions, the enrichment of heterogeneous catalysts such as metal oxides, graphene-based composites, doped metal nanoparticles, and molecular sieve-based porous materials, asymmetric synthesis, and other areas. The aim of this review is to contribute to the development of green and sustainable heterogeneous reaction methods for quinoxalin-2(1H)-ones with applications in materials chemistry and pharmacology.
Amino-Termination of Silicon Carbide Nanoparticles
Authors: Czene Szabolcs , Jegenyes Nikoletta , Krafcsik Olga , Lenk Sándor , Czigány Zsolt , Bortel Gábor , Kamarás Katalin , Rohonczy János , Beke David , Gali Adam
Published: June 2023

Silicon carbide nanoparticles (SiC NPs) are promising inorganic molecular-sized fluorescent biomarkers. It is imperative to develop methods to functionalize SiC NPs for certain biological applications. One possible route is to form amino groups on the surface, which can be readily used to attach target biomolecules. Here, we report direct amino-termination of aqueous SiC NPs. We demonstrate the applicability of the amino-terminated SiC NPs by attaching bovine serum albumin as a model for functionalization. We monitor the optical properties of the SiC NPs in this process and find that the fluorescence intensity is very sensitive to surface termination. Our finding may have implications for a few nanometers sized SiC NPs containing paramagnetic color centers with optically read electron spins.
Barium Titanate/Gadolinium Ferrite: A New Material Composite to Store Energy
Authors: Baivier Clara , Hammami Imen , Benzerga Ratiba , Graça Manuel P. F. , Costa Luís C.
Published: June 2023

This work investigates the dielectric properties of barium titanate/gadolinium ferrite ceramic composites, with different concentrations of each material. Our objective was to increase the storage ability of this material, finding a compromise between high permittivity and low dielectric losses. A two-step sintering procedure was used in the preparation of the composites to attain the desired results. Their morphological, structural and electrical properties were tested using scanning electron microscopy, X-Ray powder diffraction and impedance spectroscopy, respectively. Dielectric characterizations were performed on the frequency band of 100 Hz–1 MHz and for different temperatures (180–380 K). The best compromise between barium titanate and gadolinium ferrite in the composition was calculated in order to obtain a potential material for electrical energy storage. The sample with 25% gadolinium ferrite presented the best results. The dielectric constant reached values of the order of 2000, at 1 kHz and 340 K. It was also important not to have very high losses, and this was confirmed by the calculated loss tangent.
Rapid Microwave-Assisted Synthesis of ZnIn2S4 Nanosheets for Highly Efficient Photocatalytic Hydrogen Production
Authors: Chang Yu-Cheng , Chiao Yung-Chang , Hsu Po-Chun
Published: June 2023

In this study, a facile and rapid microwave-assisted synthesis method was used to synthesize In2S3 nanosheets, ZnS nanosheets, and ZnIn2S4 nanosheets with sulfur vacancies. The two-dimensional semiconductor photocatalysts of ZnIn2S4 nanosheets were characterized by XRD, FESEM, BET, TEM, XPS, UV–vis diffuse reflectance, and PL spectroscopy. The ZnIn2S4 with sulfur vacancies exhibited an evident energy bandgap value of 2.82 eV, as determined by UV–visible diffuse reflectance spectroscopy, and its energy band diagram was obtained through the combination of XPS and energy bandgap values. ZnIn2S4 nanosheets exhibited about 33.3 and 16.6 times higher photocatalytic hydrogen production than In2S3 nanosheets and ZnS nanosheets, respectively, under visible-light irradiation. Various factors, including materials, sacrificial reagents, and pH values, were used to evaluate the influence of ZnIn2S4 nanosheets on photocatalytic hydrogen production. In addition, the ZnIn2S4 nanosheets revealed the highest photocatalytic hydrogen production from seawater, which was about 209.4 and 106.7 times higher than that of In2S3 nanosheets and ZnS nanosheets, respectively. The presence of sulfur vacancies in ZnIn2S4 nanosheets offers promising opportunities for developing highly efficient and stable photocatalysts for photocatalytic hydrogen production from seawater under visible-light irradiation.
Contribution of Chronic Sleep Deprivation to Age-Related Neurodegeneration in a Mouse Model of Familial Alzheimer’s Disease (5xFAD)
Authors: Klimenko Maria O. , Mishchenko Tatiana A. , Mitaeva Yaroslava I. , Kondakova Elena V. , Mitroshina Elena V. , Vedunova Maria V.
Published: June 2023

Sleep–wake cycle disorders most often accompany the elderly and are frequently associated with the development of neurodegenerative processes, primarily Alzheimer’s disease. Sleep disturbances can be diagnosed in patients with AD even before the onset of memory and cognitive impairment, and become more pronounced as the disease progresses. Therefore, the expansion of our knowledge of how sleep relates to AD pathogenesis needs to be addressed as soon as possible. Here, we investigated the influence of chronic sleep deprivation on the motor and orienting–exploratory activity of 5xFAD mice, as well as their spatial learning ability and long-term memory retention. The studies carried out revealed that chronic sleep deprivation negatively affects the processes of spatial memory reconsolidation in 5xFAD mice. This leads to the development of stress-related behavioral responses, including aggressive behavior. In addition, the morphological changes in the cerebral cortex, including changes in the nuclear–cytoplasmic ratio and degradation of neuronal processes are observed. Moreover, we found an increase in the level of total DNA methylation in the blood of the sleep-deprived mice, which may be one of the mechanisms of the two-way relationship between sleep and neurodegeneration.
Comment on Clayton-Chubb et al. Understanding NAFLD: From Case Identification to Interventions, Outcomes, and Future Perspectives. Nutrients 2023, 15, 687
Authors: Abenavoli Ludovico , La Torre Giuseppe , Milic Natasa
Published: June 2023

This letter is to comment on the article by Clayton-Chubb et al. on the pathogenesis of non-alcoholic fatty liver disease and its outcomes, and the description of current, emerging and future directions to treat this condition [...]
Evaluating a 10-Week Family-Focused E-Health Healthy Lifestyle Program for School-Aged Children with Overweight or Obesity: A Randomized Controlled Trial Study Protocol
Authors: Zhu Diana , Dordevic Aimee L. , Gibson Simone , Davidson Zoe E.
Published: June 2023

E-Health childhood obesity treatment interventions may serve as favorable alternatives to conventional face-to-face programs. More studies are needed to evaluate the effectiveness of such interventions beyond immediately post-program completion, including exploring program features impacting effectiveness. This randomized controlled trial with a qualitative component and waitlisted control group will evaluate the effectiveness of a 10-week family-focused e-Health program for school-aged children with overweight/obesity and explore the experience of families completing the program. The primary outcome is the change in BMI z-score and will be assessed from baseline to 10 weeks. Secondary outcomes include (the change in) waist circumference, dietary intake, physical activity, quality of life, and experiences, and will be assessed at baseline, post-10 weeks, and/or immediately, 3-, 6-, and/or 12-months post-program completion. Independent t-tests will be used to compare the differences in means and analyses of variances (ANOVAs) will be conducted to investigate the impact of the program or of being waitlisted and the effect size of the program on quantitative outcome measures. Reflexive thematic analysis will be used with qualitative data. Findings from this study are expected to provide learnings to upscale conventional childhood obesity treatment services, in the hopes of curbing the rising rate of childhood obesity.