bluuebunny/crossref_metadata_2025 huggingface dataset:
Extraction and Characterization of Natural Antioxidants from Olive Leaves Powder
Authors: Saeed Muhammad Khalid , Shehzadi Iram , Zahra Naseem , Anjum Shaheena , Huma Zille , Ur Rehman Khalil
Published: April 2024

Olive (Olea europaea L.) leaves, which contain large amounts of phenols, are a common byproduct in the production of olive oil. When improperly processed, the by-products produced by the olive diligence can impairment the environment. Its leaves, which are made when olive trees are pruned and harvested and it is expected that foliage make up twenty five percent of pruning remains overall. These byproducts cost manufacturers money and have serious environmental implications. So, like other agronomical production wastes, partial reuse is something that should be pursued. These leftovers have a high concentration of beneficial chemicals, if isolated, may be used in food, cosmetics and nutraceutical sectors. Objectives: To extract the bioactive compounds polyphenols and flavonoids in 70% ethanol extract and its antioxidant activity was done. Methods: The polyphenols were quantified by Folin reagent and flavonoids by aluminum chloride methods respectively and the natural antioxidants were estimated by using free radical scavenging DPPH assay. Results: It was discovered that the 70% ethanol extract's total polyphenolic content was 65.50 ± 1.42 (mg GAE/g) and its total flavonoids were 11.85 ± 0.60 (mg QE/g). In 70% ethanol extract the % inhibition (DPPH) was 42.82±3.20-88.40±5.18 while BHT has the % inhibition (DPPH) 30.4 ± 2.50-80.50 ± 4.68 at concentration 0.1-0.5 mg/ml. Conclusions: The results indicating a noteworthy antioxidant activity in terms of radical scavenging activity. These results also wrapped up that the olive industry waste may be reutilized as a natural source of antioxidants in various sectors.
SARS-CoV-2 and Angiotensin-Converting Enzyme-2 Receptor Interaction Blocker– an In-Silico Approach
Authors: Khan Zoha , Suleman Muhammad , Tariq Hamna , Mumtaz Mehvish , Azam Hafiz Muhammad Husnain , Hussain Nazim , Sarfraz Hadia , Baqar Zulqarnain , Munir Haris , Zulfiqar Moeen
Published: April 2024

The global COVID-19 pandemic, instigated by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), has led to substantial morbidity and mortality on a worldwide scale. While COVID-19 vaccines offer hope, the emergence of mutated viral strains necessitates the development of FDA-approved drugs to address future outbreaks. Objective: To examine prospective antiviral medications through an analysis of the interaction between the spike protein of SARS-CoV-2 and Angiotensin-converting enzyme-2 (ACE-2) receptors, which play a pivotal role in facilitating viral entry into host cells. Methods: Molecular docking was employed to assess the binding affinities of various protease inhibitors with ACE-2 receptors. Natural proteases, including Furin and Transmembrane serine protease 2 (TMPRSS2), cleave viral spike proteins into S1 and S2 subunits, facilitating fusion with ACE-2 receptors. We assessed the binding energies of Indinavir, Nafamostat, Fosamprenavir, Lopinavir, and Boceprevir to inhibit this interaction with a sense of optimism for their potential therapeutic applications. Results: Our findings suggest potential treatments for COVID-19, with Indinavir, Nafamostat, Fosamprenavir, Lopinavir, and Boceprevir displaying promising binding energies of -9.6 kcal/mol, -8.4 kcal/mol, -7.7 kcal/mol, and -7.5 kcal/mol, respectively. Conclusions: While promising, further clinical trials are important to potentially evaluate the efficacy and safety of these proposed drugs in combating COVID-19 and its variants.
Thoughts and countermeasures of establishing national modern agricultural demonstration zone——Take Shijiazhuang City, Hebei Province as an example
Authors: Xing Donghai , Geng Jishen , Du Xiaodong , Cai Haiyan
Published: April 2024

The modern agricultural demonstration area is of far-reaching significance to promote the development of modern agriculture. According to the current situation of agricultural industry development in Shijiazhuang, this paper analyzes the development conditions of establishing a national modern agricultural demonstration zone, puts forward the basic ideas, development orientation, and development countermeasures of building a national modern agricultural demonstration zone, and analyzes the guarantee measures for its development in order to build Shijiazhuang into a national modern agricultural demonstration zone.
Efficacy of different irrigation methods in saving water and ameliorating pollution in paddy field: Take Pinghu as an example
Authors: Xu Yi , Wu Yongxiang , Wang Gaoxu , Liu Pei , Guo Ting
Published: April 2024

Objective: Improving water use efficiency and ameliorating pollution is a challenge facing agriculture, and this paper aims to present an experimental study on the efficacy of different irrigation methods in saving water and reducing pollution in paddy fields in an attempt to provide suitable management for paddy fields in plain regions. Method: We examined three irrigation methods: flooding irrigation, shallow-water irrigation, and rain-collecting irrigation in Pinghu, Zhejiang province. For each irrigation, we measured TN, TP, NH4+-H, NH3-N, and COD in both irrigation water and drainage water. Result: Compared with flooding and shallow-water irrigation, rain-collecting irrigation reduced the amount of irrigation water by 67.4% and 43.4%, TN loss by 86.9% and 90.7%, emissions of NH4+-H by 96.7% and 98.3%, and COD emissions by 61.5% and 62.5%, respectively. The difference in change of TP and NH3-N between all three irrigation methods was not significant. Conclusion: For the areas we studied, rain-collecting irrigation is most effective in saving water and reducing pollution.
Pernyataan Iman Menurut Roma 10:9 dan Relevansinya bagi Kaum Difabel Kategori Tunawicara
Authors: Wicaksono Arif , Sumisu Laurens Ruben
Published: April 2024

The statement of faith according to Romans 10:9 is a call to confess Jesus Christ as Lord and accept His resurrection from the dead. This verse emphasizes the importance of verbal confession of the Christian faith and belief in the heart in the truth of Christ's resurrection as the basis for salvation. For disabled people in the speech category, who may face communication challenges. In order to find the relevance of this confession of faith to the faith of the Speech Impaired, the author uses a literature study approach. Based on research conducted, confession does not always have to be verbal. Confession of faith can be done in a deep heart and awareness of the universal gift of salvation, not limited by communication limitations. The relevance of Romans 10:9 for the deaf category lies in their ability to experience, express, and celebrate the Christian faith through various forms of communication, while the Church provides support and inclusivity to ensure their safety and spiritual growth.ABSTRAKPernyataan iman menurut Roma 10:9 adalah panggilan untuk mengakui Yesus Kristus sebagai Tuhan dan mempercayai kebangkitan-Nya dari antara orang mati. Ayat ini menekankan pentingnya pengakuan verbal terhadap iman Kristen dan keyakinan dalam hati akan kebenaran kebangkitan Kristus sebagai dasar keselamatan. Bagi kaum difabel kategori tunawicara, yang mungkin menghadapi tantangan komunikasi. Guna menemukan relevansi pengakuan iman ini terhadap keimanan kaum Tuna wicara penulis menggunakan  pendekatan studi pustaka. Berdasarkan penelitian yang dilakukan pengakuan tidak selalu harus bersifat verbal. Pengakuan iman dapat dilakukan dalam hati yang mendalam serta kesadaran akan anugerah keselamatan yang universal, tidak terbatas oleh keterbatasan komunikasi. Relevansi Roma 10:9 bagi kaum difabel kategori tunawicara terletak pada kemampuan mereka untuk mengalami, menyatakan, dan merayakan iman Kristen melalui berbagai bentuk komunikasi, sementara gereja memberikan dukungan dan inklusivitas untuk memastikan keselamatan dan pertumbuhan rohani mereka.. Kata-kata kunci: Difabel, Pernyataan Iman, Roma 10:9, Tunawicara.
Studi Pengembangan Konseling Kristen dalam Memengaruhi Penerimaan Diri
Authors: Deak Victor , Geovani Loveilia
Published: April 2024

This research  focuses on the role of Christian Cognitive-Behavioral Therapy (C-CBT) in the self-acceptance process during young adulthood, by integrating aspects of Christian counseling and Christian identity formation. The study proposes that the integration of cognitive-behavioral principles with Christian values and teachings can offer a unique and effective approach to addressing self-acceptance issues. The research methodology employs a qualitative approach. Results indicate that C-CBT significantly contributes to improved self-acceptance, achieved through self-reflection driven by Christian values, understanding, and reinterpretation of beliefs about oneself in the light of Christian faith. It was also found that the process of Christian identity formation, reinforced through C-CBT, plays an important role in supporting self-acceptance. The integration of cognitive-behavioral and Christian counseling elements offers a valuable and effective approach in supporting self-acceptance during young adulthood. ABSTRAKPenelitian ini berfokus pada peranan terapi kognitif-perilaku Kristen (Christian Cognitive-Behavioral Therapy, C-CBT) dalam proses penerimaan diri pada masa dewasa muda, dengan mengintegrasikan aspek konseling Kristen dan formasi identitas Kristen. Kajian ini mengusulkan integrasi prinsip-prinsip kognitif-perilaku dengan nilai-nilai dan ajaran Kristen yang dapat menawarkan pendekatan unik dan efektif untuk mengatasi masalah penerimaan diri. Metodologi penelitian ini menggunakan pendekatan kualitatif. Hasil penelitian menunjukkan bahwa C-CBT secara signifikan berkontribusi terhadap peningkatan penerimaan diri, dicapai melalui refleksi diri yang didorong oleh nilai-nilai Kristen, pemahaman dan reinterpretasi keyakinan tentang diri sendiri dalam cahaya iman Kristen. Ditemukan juga bahwa proses formasi identitas Kristen, yang diperkuat melalui C-CBT, memainkan peran penting dalam mendukung penerimaan diri. Integrasi kognitif-perilaku dan elemen-elemen konseling Kristen menawarkan pendekatan yang berharga dan efektif dalam mendukung penerimaan diri pada masa dewasa muda. Kata-kata kunci: Konseling Kristen; Penerimaan Diri; Pengembangan Identitas; Krisis; Emerging Adulthood
MANIFESTAÇÕES DERMATOLÓGICAS EM CRIANÇAS COM OBESIDADE: UMA REVISÃO INTEGRATIVA DE LITERATURA
Authors: Martins Jackerson Álvaro Emmanuel , Nogueira Adriana Karim de Araújo , Vasconcelos Clara Batista Saturnino de , Rodríguez Valéria Chávez , Costa Ruth Silva Lima da
Published: April 2024

A obesidade é uma doença crônica metabólica e inflamatória que afeta pessoas de todas as idades, e as crianças não são uma exceção, visto que houve um aumento significativo em sua incidência nos últimos anos. A pele é sensível a vários estímulos endógenos e exógenos e é influenciada pela obesidade. Este estudo consiste em uma revisão integrativa da literatura realizada de fevereiro a março de 2024, utilizando as bases de dados MEDLINE/PubMed e BioMed Central (BMC), com o objetivo de descrever as principais manifestações dermatológicas associadas à obesidade em crianças. Nove artigos foram identificados e selecionados para compor a amostra final. Da análise desses estudos, surgiram dois pontos de discussão: as patologias cutâneas associadas à obesidade em crianças e as possíveis associações fisiopatológicas dessas doenças com o excesso de peso. Os resultados indicam que a obesidade é um fator de risco para atopias de pele e doenças autoimunes, além de uma maior predisposição a infecções secundárias e outras condições, como acantose nigricans e estrias de pele. No entanto, a relação causal precisa entre obesidade e dermatopatias ainda é objeto de controvérsia. Mais estudos devem ser realizados com objetivo de esclarecimento, especialmente no que diz respeito a anormalidades cutâneas em pacientes obesos pediátricos.
POTENCIAL ALELOPÁTICO DE EXTRATOS AQUOSOS DA FOLHA DE JURUBEBA SOBRE GERMINAÇÃO E CRESCIMENTO INICIAL DE ALFACE
Authors: Oliveira Talita Costa de , Cuchi Giovana , Cardoso Elisa dos Santos , Roveda Ana Paula , Pedri Eliane Cristina Moreno de , Tiago Auana Vicente , Francisco Bruno Goularte , Rossi Ana Aparecida Bandini
Published: April 2024

A alelopatia tem sido reconhecida como importante método ecológico de controle para plantas espontâneas, que influencia no domínio e progresso das plantas, criação de novas associações, diversidade biológica, controle e produtividade de culturas. Diante disso, objetivou-se neste estudo avaliar o potencial alelopático de diferentes concentrações de extratos aquosos da folha de jurubeba (Solanum paniculatum L.) na germinação e no crescimento inicial da alface (Lactuca sativa L.). O experimento foi conduzido em delineamento inteiramente casualizado (DIC) com esquema fatorial 2 x 5 + 1, sendo dois extratos aquosos (macerado e decocto), cinco concentrações (3, 6, 12, 25 e 50 mg mL-1) e água destilada como controle negativo (0 mg mL-1). Foram realizadas quatro repetições, compostas por 50 sementes cada, totalizando 200 sementes por concentração. As variáveis analisadas foram: percentual de germinação (PG), índice de velocidade de germinação (IVG), tempo médio de germinação (TMG), comprimento da parte aérea (CPA) e comprimento da parte radicular (CPR). O PG das sementes de alface sofreu inibição devido ao aumento das concentrações nos dois tipos de extratos aquosos. Para a variável IVG houve uma redução significativa para o extrato macerado na concentração de 12 mg mL-1. Quanto à variável TMG, houve diferença significativa entre os extratos apenas na concentração de 12 mg mL-1. Na variável CPA, houve diferença estatística e significativa nas concentrações testadas. A variável CSR apresentou diferença estatística para os dois extratos aquosos. Verificou-se que os extratos aquosos testados influenciaram em todas as variáveis, onde as maiores concentrações levaram a menores médias. Conclui-se que extratos aquosos de folhas de jurubeba exercem efeito alelopático sobre a germinação e o crescimento inicial das plântulas de alface.
A IMPORTÂNCIA DA MONITORIA PARA APRENDIZAGEM DOS FUNDAMENTOS DA EDUCAÇÃO NO CURSO DE LICENCIATURA EM EDUCAÇÃO FÍSICA
Authors: Alves João Fillype Vasconcelos Viana , Santos Francisco Xavier dos , Lima Isael João de , Silva Liliane Farias Cabral Borges da , Barreto Magna Sales , Ferreira Monica Maria do Carmo , Silva João Lucas Ferreira Bonifacio e , Nascimento Eduarda Vitória de Melo , Santana José Daniel Barbosa de
Published: April 2024

O programa de monitoria tem como finalidade proporcionar uma experiência enriquecedora no processo de formação, onde destaca-se a participação do aluno monitor na função de aprendiz docente, como forma de produção de saberes e experiências enriquecedoras durante o desenvolvimento do processo de ensino e aprendizagem da monitoria no curso de Licenciatura em Educação Física. O presente trabalho, trata-se de relato de experiência a partir da vivência dos discentes/monitores na disciplina de fundamentos da educação, ministrada no curso de graduação Licenciatura em Educação Física na Universidade Federal de Pernambuco no Centro Acadêmico da Vitória de Santo Antão, disciplina ofertada no 1⁰ período. Tal experiência ocorreu durante o período presencial pós-pandemia no semestre letivo 2022.1 a 2022.2 com duração de 4 meses. Sendo possível, aprofundar nos conhecimentos teóricos dos movimentos que constituíram a Educação brasileira, tais como movimento iluminista, movimento positivista e o movimento escolanovista, elencando os principais teóricos que são referência na efetivação desses movimentos e correlacionando os principais conceitos com a Educação Física escolar. Pode-se considerar neste processo de formação docente, as funções didático-pedagógicas desempenhadas pelos monitores na qual  consistiu no apoio aos estudantes na disciplina, na elaboração e resolução de exercícios, em desenvolvimento de projetos didáticos acadêmicos, produção de seminários, compreensão da bibliografia básica da disciplina, orientação quanto às dúvidas dos conteúdos ministrados em sala de aula e ainda, em situações na qual o professor orientador necessitou de auxílio. Podemos afirmar que, a experiência da monitoria possibilitou um desenvolvimento de habilidades de pesquisa, de produção acadêmica de trabalhos para eventos e discussões sobre conceitos importantes tais como Ensino, Educação e Aprendizagem e prática pedagógica refletindo a partir das conexões os conceitos e relação teoria e prática para compreensão de uma sociedade sábia a partir de questionamentos teóricos, didáticos e educativos, contribuindo na constituição de profissionalização docente dos monitores.
Vữa nhẹ sử dụng cốt liệu cao su tái chế từ lốp xe và hạt vi cầu rỗng từ tro bay
Authors: Trần Đức Trung
Published: April 2024

Bài báo này trình bày kết quả nghiên cứu, chế tạo vữa nhẹ trên cơ sở sử dụng cốt liệu cao su (CS) tái chế từ lốp xe và hạt vi cầu rỗng từ tro bay (CE), trong đó CS được xử lý bề mặt bằng cách ngâm với dung dịch NaOH nồng độ 20% trong 30 phút. Nghiên cứu cho thấy có thể sử dụng tỷ lệ về thể tích giữa CS và cát tự nhiên (CV) là 40:60 hoặc 50:50, hàm lượng CE sử dụng thay thế thể tích xi măng (XM) từ 10÷40%, lượng dùng XM là 450kg/m3, tỷ lệ N/CKD là 0,4 và phụ gia siêu dẻo (PGSD) để chế tạo vữa có khối lượng thể tích khô (KLTT) từ 1300÷1500kg/m3, cường độ nén ở tuổi 28 ngày lớn hơn 5MPa. Kết quả nghiên cứu cũng cho thấy KLTT, cường độ nén, cường độ uốn, cường độ bám dính, độ hút nước...của vữa phụ thuộc rất nhiều vào hàm lượng CS, CE và mô đul độ lớn của CS, nhưng hầu như không bị ảnh hưởng bởi phụ gia khoáng hoạt tính (PGK) sử dụng.
ĐÁNH GIÁ NGUY CƠ NGÃ Ở NGƯỜI BỆNH CAO TUỔI SAU ĐỘT QUỴ
Authors: Nguyễn Thị Thu Hương , Nguyễn Ngọc Tâm , Trần Viết Lực
Published: April 2024

Mục tiêu: đánh giá nguy cơ ngã và một số yếu tố liên quan trên người bệnh cao tuổi sau đột quỵ. Đối tượng và phương pháp: Nghiên cứu mô tả cắt ngang trên 107 người bệnh ³ 60 tuổi được chẩn đoán đột quỵ não khám và điều trị tại Bệnh viện Lão Khoa Trung ương từ tháng 07-11/2021. Nguy cơ ngã được đánh giá bằng bảng đánh giá nguy cơ ngã 21 câu hỏi.  Kết quả: Tỉ lệ người bệnh có nguy cơ ngã cao là 69,2%. Tỉ lệ nguy cơ ngã cao ở nam là 70,4% và ở nữ là 67,9%. Tuổi càng cao thì nguy cơ ngã càng cao. Tuổi trung bình của nhóm nguy cơ ngã cao cao hơn có ý nghĩa thống kê so với ở nhóm nguy cơ ngã thấp. Triệu chứng liệt nửa người, đột quỵ nhồi máu não và mức độ di chứng sau đột quỵ càng nặng có mối liên quan có ý nghĩa thống kê với nguy cơ ngã (p<0,05). Không có sự khác biệt có ý nghĩa thống kê giữa nguy cơ ngã và giới, chỉ số khối cơ thể, một số bệnh đồng mắc, số lần đột quỵ và thời gian chẩn đoán đột quỵ não. Kết luận: cứ hai trong ba người bệnh cao tuổi sau đột quỵ có nguy cơ ngã cao. Nguy cơ ngã có mối liên quan với tuổi cao, triệu chứng liệt nửa người, đột quỵ nhồi máu não và mức độ di chứng sau đột quỵ.
TÌNH TRẠNG RỐI LOẠN GIẤC NGỦ VÀ ĐẶC ĐIỂM LÃO KHOA TRÊN NGƯỜI BỆNH SAU ĐỘT QUỴ
Authors: Nguyễn Thị Hoài Thu , Nguyễn Ngọc Tâm , Hoàng Cúc , Trần Viết Lực
Published: April 2024

Mục tiêu: Đánh giá tình trạng rối loạn giấc ngủ và các đặc điểm lão khoa trên người bệnh cao tuổi sau đột quỵ.

Phương pháp nghiên cứu:  Nghiên cứu mô tả cắt ngang thực hiện trên người cao tuổi sau đột quỵ tại bệnh viện Lão khoa Trung ương. Chúng tôi sử dụng thang điểm The Pittsburgh Sleep Quality Index (PSQI) để đánh giá tình trạng rối loạn giấc ngủ. Đặc điểm lão khoa bao gồm hoạt động hàng ngày, tình trạng dinh dưỡng, mệt mỏi, đa bệnh lý và trầm cảm. Nghiên cứu sử dụng SPSS 22.0 để phân tích số liệu.

Kết quả: Tổng số 138 bệnh nhân trong nghiên cứu với độ tuổi trung bình là 74,59 (độ lệch chuẩn là 8,45). Tỉ lệ rối loạn giấc ngủ là 75,4%. Tỉ lệ bệnh nhân phụ thuộc là 82,6% với 114 người. Nhóm có nguy cơ suy dinh dưỡng là 60 bệnh nhân với 43,5%. Bệnh nhân có từ 5 bệnh lý trở lên chiếm 30,4%. Điểm trung bình của mệt mỏi là 4,73±1,66.

Kết luận: Tỉ lệ rối loạn giấc ngủ trên người bệnh sau đột quỵ khá cao. Cần sàng lọc rối loạn giấc ngủ cho bệnh nhân sau đột quỵ để cải thiện chất lượng cuộc sống của đối tượng trên.
ĐÁNH GIÁ RỐI LOẠN CHUYỂN HÓA CALCI – PHOSPHO – PTH Ở BỆNH NHÂN CAO TUỔI LỌC MÁU CHU KỲ TẠI KHOA THẬN TIẾT NIỆU – LỌC MÁU, BỆNH VIỆN HỮU NGHỊ
Authors: Trịnh Thị Thanh Hằng , Nguyễn Hữu Việt , Nguyễn Thế Anh
Published: April 2024

Mục tiêu: Đánh giá nồng độ caclci, phospho, PTH và một số yếu tố liên quan ở bệnh nhân cao tuổi lọc máu chu kỳ. Đối tượng: 82 bệnh nhân cao tuổi lọc máu chu kỳ tại khoa Thận tiết niệu – Lọc máu, bệnh viện Hữu Nghị, từ tháng 10/2023 đến tháng 12/2023. Phương pháp nghiên cứu: Mô tả cắt ngang. Kết quả: Tuổi trung bình bệnh nhân nghiên cứu là 75.87 ± 8.485 tuổi; tỷ lệ bệnh nhân nam chiếm 68.3% cao hơn bệnh nhân nữ; thời gian lọc máu trung bình là 4.94 ± 4.67 năm; bệnh nhân có chỉ số khối cơ thể trong giới hạn bình thường chiếm tỷ lệ 62.2%. Theo tiêu chuẩn KDIGO 2017 ở bệnh nhân bệnh thận mạn giai đoạn V, trong nhóm nghiên cứu nồng độ calci toàn phần hiệu chỉnh đạt tiêu chuẩn chiếm tỷ lệ 58.5%, nồng độ phospho đạt tiêu chuẩn chiểm 50%, nồng độ PTH đạt tiêu chuẩn chiếm 25.6%, Ca x P đạt tiêu chuẩn chiếm 68.3%. Nồng độ calci toàn phần hiệu chỉnh, PTH có mối tương quan thuận với thời gian lọc máu.
KHẢO SÁT ĐẶC ĐIỂM CHỨC NĂNG THÔNG KHÍ PHỔI Ở BỆNH NHÂN SAU NHIỄM COVID-19
Authors: Phạm Ngọc Thảo , Đỗ Đức Thuần
Published: April 2024

Mục tiêu: Nghiên cứu tỷ lệ rối loạn thông khí phổi ở bệnh nhân sau nhiễm COVID-19 Phương pháp: Tổng số 111 bệnh nhân sau nhiễm COVID-19 với tiền sử không mắc các bệnh lý hô hấp đi kiểm tra sức khỏe về chức năng thông khí phổi tại Bệnh viện Quân y 103 được thu thập từ tháng 2/2022 tới tháng 5/2022. Chức năng thông khí phổi của bệnh nhân được đánh giá bằng phương pháp đo hô hấp ký. Phân tích hồi quy nhị phân (Binary Logistic) được sử dụng để phân tích mối liên quan giữa có biểu hiện rối loạn chức năng thông khí phổi với mức độ bệnh khi nhiễm COVID-19 sau khi hiệu chỉnh cho giới tính và thời gian sau nhiễm COVID-19. Kết quả: Tỷ lệ bệnh nhân có biểu hiện giảm FVC (%) và PEF (%) lần lượt là 30.6% và 61.2%. Tỷ lệ bệnh nhân có giảm về FEV1/FVC (%) và FEF 25-75% là 4.5%. Tăng tỷ lệ bệnh nhân có biểu hiện giảm FVC (%) được quan sát ở nhóm bệnh nhân sau mắc COVID-19 mức độ nặng so với nhóm bệnh nhân mắc COVID-19 mức độ nhẹ ((OR: 4.363, p< 0.05). Kết luận: Kết quả này chỉ ra tăng tỷ lệ biểu hiện các rối loạ
Contents
Authors: Tudball Daniel
Published: April 2024

Contents
Sir David Hendry: An Appreciation from Wall Street and What Macroeconomics Got Right
Authors: Guerard John
Published: April 2024

Professor Hendry�s software, Autometrics, could be a great resource of enormous value to portfolio construction and management as a tool for portfolio lambda setting.
A Quantum Model of Implied Volatility
Authors: Orrell David
Published: April 2024

The quantum implied volatility (QIV) model is a minimalistic model of an implied volatility surface. It is derived by assuming that the implied volatility is the volatility which, when used as input to the Black-Scholes model, will produce the correct option price under a previously derived quantum model of asset price. In its base form, the model uses only two parameters to simulate a volatility surface over different strikes and expirations. Results can be improved by adding additional parameters, such as a drift term. The method is illustrated using data from the S&P 500 index, as well as individual stocks.
Psychiatric outcomes in outpatients affected by long COVID: A link between mental health and persistence of olfactory complaint
Authors: Metelkina-Fernandez Victoria , Dumas Louise-Emilie , Vandersteen Clair , Chirio David , Gros Auriane , Fernandez Arnaud , Askenazy Florence , Manera Valeria
Published: April 2024

BACKGROUND

Anosmia was one of the main symptoms of coronavirus disease 2019 (COVID-19). A psychiatric history (i.e., depression) may be an independent contributor to the risk of COVID-19 diagnosis, and COVID-19 survivors appear to have an increased risk of neuropsychiatric sequelae (bidirectional association).

AIM

To compare the rate of psychiatric disorder among post-COVID patients without anosmia vs patients with persistent olfactory complaints.

METHODS

We conducted a prospective case control study from March 2020 to May 2021. Patients recruited at the ENT department of Nice University Hospital had a subjective olfactory complaint (visual analogue scale) for over 6 wk and a molecular or CT-proven severe acute respiratory syndrome coronavirus 2 diagnosis confirmed by serology. Post-COVID patients without persistent olfactory disorders were recruited at the university hospital infectiology department. Psychiatric medical histories were collected by a psychiatrist during the assessments.

RESULTS

Thirty-four patients with post-COVID-19 olfactory complaints were included in the first group of the study. Fifty percent of the patients were female (n = 17). The group’s mean age was 40.5 ± 12.9 years. The control group included 32 participants, of which 34.4% were female (n = 11), and had a mean age of 61.2 ± 12.2 years. The rate of psychiatric disorder among post-COVID patients with olfactory complaints was significatively higher (41.7%) than among patients without (18.8%) (χ 2 = 5.9, P = 0.015).

CONCLUSION

The presence of a psychiatric history may constitute a potential risk factor for the development of long COVID due to persistent anosmia. It therefore seems important to establish reinforced health monitoring after a COVID 19 infection in at-risk patients. Further prospective, translational, and collaborative studies are needed to extrapolate these results to the general population.
Relationship between plasma risperidone concentrations and clinical features in chronic schizophrenic patients in China
Authors: Xu Jing-Wen , Guan Xiao-Bo , Wang Xue-Ying , Feng Yang , Zhang Qi , Zhu Jun-Juan , Chen Jian-Hua
Published: April 2024

BACKGROUND

Prior studies have noted great variability in the plasma levels of risperidone (RIS). Plasma concentrations of RIS and its active moiety are highly variable and depend on absorption, metabolism, and other predictors of metabolic dysregulation; however, these factors are poorly understood and the association between metabolic change and change in psychopathology is uncertain.

AIM

To ascertain the characteristics of chronic schizophrenic patients treated with RIS, and to assess their relationship with plasma RIS levels.

METHODS

This was a descriptive cross-sectional study of 50 patients with a diagnosis of schizophrenic psychosis treated with RIS in a psychiatric service. The plasma concentrations of RIS and its metabolite 9-hydroxyrisperidone were determined by high performance liquid chromatography. The patients’ demographic and clinical characteristics, and psychopathologies were assessed, and the associations between clinical variables and plasma levels of RIS were explored.

RESULTS

Male patients received higher doses of RIS than female ones, but plasma concentrations of RIS and risperidone + 9-hydroxyrisperidone (active moiety) were higher in female patients. Age and the mean scores of the general psychopathology subscale of the Positive and Negative Syndrome Scale (PANSS) were significantly positively correlated with plasma concentrations of risperidone + 9-hydroxyrisperidone adjusted for weight and dose in all 50 subjects. In male subjects, we found a statistically significant positive correlation between the concentrations of risperidone + 9-hydroxyrisperidone in plasma/(dose × kg) and age, mean PANSS negative subscale scores, mean PANSS general psychopathology subscale scores, and mean PANSS total scores.

CONCLUSION

Long-term use of RIS should be closely monitored in older patients and females to minimize the risk of high concentrations which could induce side effects.
Analysis of acupoint massage combined with touch on relieving anxiety and pain in patients with oral implant surgery
Authors: Qu Jin-Hong , Shou Cheng-Cheng , He Xin , Wang Qin , Fang Yue-Xia
Published: April 2024

BACKGROUND

Oral implant surgery is an effective procedure for artificial implants in missing tooth areas under local anesthesia. Because patients under local anesthesia are conscious during this procedure, compared with general anesthesia-related operations, they are more likely to experience negative emotions, such as anxiety and tension. These emotional reactions result in shivering and chills in the limbs, leading to poor doctor-patient cooperation and even avoidance of treatment. In traditional Chinese medicine, it is believed that acupoint massage regulates blood and Qi, dredge menstruation, and relieve pain, which is beneficial for patients’ emotional adjustment; however, there are few related clinical studies.

AIM

To observe the changes in anxiety and pain in patients with oral implant after acupoint massage combined with touch therapy.

METHODS

One hundred patients undergoing oral implantation in our hospital between May 2020 and May 2023 were randomly divided into control and study groups, according to a random number table, with 50 patients in each group. The control group received routine intervention, and the study group received acupoint massage combined with touch on the basis of the control group. Anxiety [assessed using the Modified Dental Anxiety Scale (MDAS)], pain severity, blood pressure, heart rate, and satisfaction were compared between the two groups.

RESULTS

Before intervention, the difference in MDAS score between the two groups was not significant (P > 0.05), while after the intervention, the MDAS scores decreased in both groups compared with those before the intervention (P < 0.05); the MDAS score of the study group was lower than that of the control group, with a statistically significant difference (P < 0.05). The degree of pain in the intervention group was significantly lower than that in the control group (P < 0.05). Before the intervention, there were no significant differences in systolic and diastolic blood pressures or heart rate between the two groups (P > 0.05). The systolic and diastolic blood pressures and heart rate in the intervention group, during and after the intervention, were significantly lower than those in the control group (P < 0.05). The total degree of satisfaction in the study group was significantly higher than that in the control group (P < 0.05).

CONCLUSION

Acupoint massage combined with touch better relieves anxiety and pain in patients undergoing dental implant surgery, improving the perioperative comfort of these patients and ensuring safety and a smooth operation.
Resilience provides mediating effect of resilience between fear of progression and sleep quality in patients with hematological malignancies
Authors: Tian Yuan , Wang Ying-Li
Published: April 2024

BACKGROUND

Hematological tumors are common malignant tumors, with high morbidity and mortality rates. Most patients with hematological malignancies develop sleep disorders that seriously affect their life and health because of acute onset of disease, rapid progression, high recurrence rates, complex treatment methods, and treatment costs.

AIM

To explore the mediating effect of resilience on fear of disease progression and sleep quality in patients with hematological malignancies.

METHODS

A cross-sectional analysis of 100 patients with hematological malignancies, treated in the First Affiliated Hospital of Jinzhou Medical University between August 2022 and August 2023, was conducted. Patients were assessed using a general data survey, a simplified scale for the fear of progression (FoP) of disease, a resilience scale, and the Pittsburgh Sleep Quality Index. Statistical analysis was conducted to determine the relationship between various patient characteristics and FoP, resilience, and sleep quality. Spearman’s correlation analysis was used to examine the correlations between mental resilience, FoP, and sleep quality.

RESULTS

The total FoP score mean value in patients with hematological malignancies was 38.09 ± 5.16; the total resilience score mean value was 40.73 ± 7.04; and the Pittsburgh Sleep Quality Index score mean value was 10.72 ± 1.90. FoP, resilience, and sleep quality of the patients were associated with family per capita monthly income and patient education level (P < 0.05). Spearman correlation analysis revealed that FoP was negatively correlated with resilience and sleep quality scores (r = -0.560, -0.537, P < 0.01), respectively, and resilience was significantly associated with sleep quality scores (r = 0.688, P < 0.01). Mediation analysis showed that the mediating effect of resilience between FoP and sleep quality in patients with hematological malignancies was -0.100 and accounted for 50.51% of the total effect. This indicated that FoP directly and indirectly affected sleep quality through the mesomeric effect of resilience.

CONCLUSION

Resilience is an intermediary variable between FoP and sleep quality in patients with hematological malignancies. Medical staff should evaluate and follow-up FoP and resilience to implement measures to improve sleep quality.
Nurse anesthetists’ perceptions and experiences of managing emergence delirium: A qualitative study
Authors: Xin Yi , Lin Fu-Cai , Huang Chen , He Bin , Yan Ya-Ling , Wang Shuo , Zhang Guang-Ming , Li Rui
Published: April 2024

BACKGROUND

This study employs a descriptive phenomenological approach to investigate the challenges anesthesia nurses face in managing emergence delirium (ED), a common and complex postoperative complication in the post-anesthesia care unit. The role of nurses in managing ED is critical, yet research on their understanding and management strategies for ED is lacking.

AIM

To investigate anesthetic nurses’ cognition and management experiences of ED in hopes of developing a standardized management protocol.

METHODS

This study employed a descriptive phenomenological approach from qualitative research methodologies. Purposeful sampling was utilized to select 12 anesthetic nurses from a tertiary hospital in Shanghai as research subjects. Semi-structured interviews were conducted, and the data were organized and analyzed using Colaizzi’s seven-step analysis method, from which the final themes were extracted.

RESULTS

After analyzing the interview content, four main themes and eight subthemes were distilled: Inefficient cognition hinders the identification of ED (conceptual ambiguity, empirical identification), managing diversity and challenges (patient-centered safe care, low level of medical-nursing collaboration), work responsibilities and pressure coexist (heavy work responsibilities, occupational risks and stress), demand for high-quality management (expecting the construction of predictive assessment tools and prevention strategies, and pursuing standardized management processes to enhance management effectiveness).

CONCLUSION

Nursing managers should prioritize the needs and suggestions of nurses in order to enhance their nursing capabilities and provide guidance for standardized management processes.
Tanshinone IIA improves Alzheimer’s disease via RNA nuclear-enriched abundant transcript 1/microRNA-291a-3p/member RAS oncogene family Rab22a axis
Authors: Yang Long-Xiu , Luo Man , Li Sheng-Yu
Published: April 2024

BACKGROUND

Alzheimer’s disease (AD) is a neurodegenerative condition characterized by oxidative stress and neuroinflammation. Tanshinone IIA (Tan-IIA), a bioactive compound isolated from Salvia miltiorrhiza plants, has shown potential neuroprotective effects; however, the mechanisms underlying such a function remain unclear.

AIM

To investigate potential Tan-IIA neuroprotective effects in AD and to elucidate their underlying mechanisms.

METHODS

Hematoxylin and eosin staining was utilized to analyze structural brain tissue morphology. To assess changes in oxidative stress and neuroinflammation, we performed enzyme-linked immunosorbent assay and western blotting. Additionally, the effect of Tan-IIA on AD cell models was evaluated in vitro using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Genetic changes related to the long non-coding RNA (lncRNA) nuclear-enriched abundant transcript 1 (NEAT1)/microRNA (miRNA, miR)-291a-3p/member RAS oncogene family Rab22a axis were assessed through reverse transcription quantitative polymerase chain reaction.

RESULTS

In vivo , Tan-IIA treatment improved neuronal morphology and attenuated oxidative stress and neuroinflammation in the brain tissue of AD mice. In vitro experiments showed that Tan-IIA dose-dependently ameliorated the amyloid-beta 1-42-induced reduction of neural stem cell viability, apoptosis, oxidative stress, and neuroinflammation. In this process, the lncRNA NEAT1 - a potential therapeutic target - is highly expressed in AD mice and downregulated via Tan-IIA treatment. Mechanistically, NEAT1 promotes the transcription and translation of Rab22a via miR-291a-3p, which activates nuclear factor kappa-B (NF-κB) signaling, leading to activation of the pro-apoptotic B-cell lymphoma 2-associated X protein and inhibition of the anti-apoptotic B-cell lymphoma 2 protein, which exacerbates AD. Tan-IIA intervention effectively blocked this process by inhibiting the NEAT1/miR-291a-3p/Rab22a axis and NF-κB signaling.

CONCLUSION

This study demonstrates that Tan-IIA exerts neuroprotective effects in AD by modulating the NEAT1/miR-291a-3p/Rab22a/NF-κB signaling pathway, serving as a foundation for the development of innovative approaches for AD therapy.
A STUDY ON WORK LIFE BALANCE OF WOMEN WORKING IN IT SECTOR IN INDIA
Authors: Patel, Monalisha
Published: April 2024

Work-life balance (WLB) is a major problem because of the many demands and challenges that women in the information technology sector face while trying to combine their personal and professional lives. This study aims to investigate the appropriate management of personal and professional life by Indian women employed in the IT sector. The paper integrates quantitative and qualitative data from more than 50 females IT workers who were polled and interviewed across Indian cities using a mixed-methods methodology. The research looks at the factors that affect women's capacity to balance work and personal life in the IT business, including working hours, workplace culture, family responsibilities, career ambitions, and social support. This article also looks at how women's performance, contentment, and overall health are affected by work-life balance. The study found that work-family conflict, high levels of stress, and burnout are common among women in IT, and that these factors negatively affect the happiness, productivity, and health of these women. The paper also outlines a number of coping strategies and best practices that the women use to balance their personal and professional life, including negotiating, self-care, delegating, and time management. The article offers a number of suggestions and methods to help women in IT occupations achieve a better work-life balance, including childcare facilities, mentorship programs, flexible work schedules, and awareness campaigns. By concentrating on the unique demands and experiences of women in India's technical advancements sector—a highly competitive and rapidly growing industry with a sizeable female workforce—the research contributes to the body of information on work-life balance. The report also offers some consequences and suggestions for more research, laws, and industrial practices in this area. This paper says that how the women employees are balanced and Satisfied in IT sector and the factors that affect the work life balance of women employees are working hours, Job satisfaction, working condition, etc. Which are key indicators in terms of measuring the work-life balance of women’s working in IT sector.
PENGAWASAN INSPEKTORAT DAERAH DALAM MEWUJUDKAN AKUNTABILITAS PENGELOLAAN DANA DESA DI KABUPATEN MALAKA
Authors: Fetomalae Michael Anjelo , Angi Yohana Febiani , Oematan Herly M.
Published: April 2024

This study aims to determine the supervisory function and constraints of the Inspectorate in realising the accountability of village fund management in Malaka Regency. The type of research used is descriptive qualitative with a case study approach with research informants inspectors, planning and finance sections and auditors of the inspectorate of Malaka Regency. This research focuses on the implementation of supervision by using data collection techniques in the form of in-depth interviews, observation, literature study and documentation. The data collected was analysed using Nvivo 12 software with the analysis method developed by Miles and Huberman. The results of this study indicate that the inspectorate has carried out supervision but not maximally due to the discovery of corruption cases that occur, one of the breakthroughs of the Inspectorate is a consultation clinic. There are three obstacles experienced by the Inspectorate, namely budget limitations, short audit time and inadequate infrastructure access.
Le coût environnemental du bonheur
Authors: Brulé Gaël
Published: April 2024

Objectif de vie pour tout un chacun, démonstration de puissance pour l’État, le bonheur fait l’objet de nombreux classements. Les indicateurs utilisés résultent toutefois de constructions fondées sur différentes idées du bonheur, incluant de manière variable la préservation du vivant. Le bien-être des sociétés occidentales en particulier repose sur un imaginaire consumériste peu en phase avec les préoccupations écologiques. Mais est-il possible aujourd’hui d’être heureux sans se soucier des limites planétaires ? Est-il envisageable d’indexer le bonheur sur d’autres récits, davantage axés sur l’émotion que sur la possession, la comparaison et leurs effets délétères ? Cet ouvrage interroge le rôle que ces palmarès du bien-être et les mesures sur lesquelles ils s’appuient jouent dans la prise en compte de l’environnement. En faisant le tour des liens entre mesures du bonheur et empreinte écologique, il sonde notre rapport au vivant là où on s’y attend le moins, au coeur même de notre quête du bonheur.
"Pa uvijek smo živjeli ovako teško…". Istraživanje putova žena do stambene isključenosti
Authors: Šikić-Mićanović Lynette
Published: April 2024

Da bismo potpunije razumjeli životne situacije žena koje žive u neadekvatnim i/ili nesigurnim životnim uvjetima, u ovoj se studiji istražuju njihovi stambeni putovi u prošlosti. Konkretno, studija istražuje njihove stambene nestabilnosti i pokuπava pratiti povijest njihova kretanja u i kroz viπe ili manje vidljiva mjesta beskuÊniπtva i stambene iskljuËenosti. Nalazi istraæivanja pokazuju da je trenutaËna æivotna situacija æena obiËno samo epizoda u dugom razdoblju nestabilnosti. Takoer, upućuju na potrebu za stalnom podrškom, po mogućnosti od rane dobi. Ova holistička studija o nedovoljno proučenoj skupini žena i neistraženoj temi postavlja nova pitanja i smjernice za potencijalno vrijedna istraživanja sa zanimljivim implikacijama za politike
Implementasi Metode Backward Chaining untuk Mendiagnosa Penyakit pada Bayi Pasca Kelahiran
Authors: Alvin Supriyan  , Arif Budimansyah Purba  , Wawan Kusdiawan  , Cepi Indra Grahana  , Rani Amalia
Published: April 2024

The critical period for the growth and development of infants can be referred to as a critical period. It is said that this critical period in infancy will be very detrimental to the environment around it and it is said that the future due to infancy is very short and cannot be repeated. Newborns are more susceptible to various diseases. Diseases in infants can be identified based on the symptoms that arise. This is caused by several factors including the lack of information about diseases in infants after birth that is known to the general public. Therefore, research is needed on diseases and symptoms that affect babies after birth. One alternative in order to find out the disease in the baby after birth can use an expert system. In building the system, the author uses the Backward Chaining method, uses the Waterfall system development method (SDLC) and the Object Oriented Approach (OOA). The result of this research is a web-based application that can later be accessed or used to make it easier for the public, especially parents of babies, to diagnose symptoms or diseases in babies after birth as early as possible.
Impact of specialized training for emergency department nurses screening or undetected HIV infection: the “Urgències VIHgila” project experience
Authors: Miró Emília , Miró Òscar , Varón Angèlica , Marrón Pepi , Canóniga Carmen , Salgado Pilar , Mola Alba , Castro Inmaculada , Montoya Ramón , Llaneras Jordi , Smithson Alejandro , Sotomayor Margarita , Robert Neus , Picart Emma , Salazar Paul , Rebollo Aleix , Gené Emili , Villamor Alberto
Published: April 2024

Objetivo. Evaluar el impacto de una formación específica para enfermería en el servicio urgencias (SU) sobre el despistaje selectivo de infección por VIH oculta. Método. Participaron 6 SU adheridos al programa “Urgències VIHgila” con un mínimo de 3 meses y se realizaron sesiones formativas para los diferentes turnos. Las sesiones enfatizaban en qué circunstancias debía sospecharse infección oculta VIH y la necesidad de solicitar serología. Se realizaron dos estudios: 1) cuasiexperimental pre/post, que comparó la tasa de solicitudes VIH entre ambos periodos, con diversos análisis de sensibilidad; 2) caso-control, que comparó el cambio entre periodos de los 6 SU con formación (caso) con el cambio en otros 6 SU que no tuvieron formación (control). Resultados. Se realizaron serologías de VIH a 280 de los 81.015 pacientes atendidos durante el periodo preintervención (0,3%) y a 331 de los 79.620 del periodo posintervención (0,4%). El incremento relativo fue del 20,3% (IC 95% de +2,9% a +34,5%; p = 0,022). Los análisis de sensibilidad mostraron incrementos relativos congruentes con el análisis principal (entre 19% y 39%). En el grupo control hubo descenso de solicitudes entre periodos, del 0,9% al 0,8% (descenso relativo del 15,7%, IC 95% de –25,1% a–6,2%; p = 0,001). El grupo caso, en relación con el grupo control, tuvo un incremento absoluto de 0,2% (IC 95% de +0,11 a +0,31%, p < 0,001) de pacientes testados. Conclusiones. La formación de enfermería para despistaje de la infección VIH oculta en urgencias incrementa el número de pacientes investigados, tanto comparado con el periodo previo a la formación como comparado con SU sin formación específica para enfermería.