bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparison Between Traditional and Alternated Resistance Exercises on Blood Pressure, Acute Neuromuscular Responses, and Rating of Perceived Exertion in Recreationally Resistance-Trained Men
Authors: Corrêa Neto Victor Gonçalves , Silva Danrley do Nascimento , Palma Alexandre , de Oliveira Francine , Vingren Jakob L. , Marchetti Paulo H. , da Silva Novaes Jefferson , Monteiro Estêvão Rios
Published: April 2024

Corrêa Neto, VG, Silva, DdN, Palma, A, de Oliveira, F, Vingren, JL, Marchetti, PH, da Silva Novaes, J, and Monteiro, ER. Comparison between traditional and alternated resistance exercises on blood pressure, acute neuromuscular responses, and rating of perceived exertion in recreationally resistance-trained men. J Strength Cond Res 38(5): e211–e218, 2024—The purpose of this study was to compare the acute effects of traditional and alternated resistance exercises on acute neuromuscular responses (maximum repetition performance, fatigue index, and volume load), rating of perceived exertion (RPE), and blood pressure (BP) in resistance-trained men. Fifteen recreationally resistance-trained men (age: 26.40 ± 4.15 years; height: 173 ± 5 cm, and total body mass: 78.12 ± 13.06 kg) were recruited and performed all 3 experimental conditions in a randomized order: (a) control (CON), (b) traditional (TRT), and (c) alternated (ART). Both conditions (TRT and ART) consisted of 5 sets of bilateral bench press, articulated bench press, back squat, and Smith back squat exercises at 80% 1RM until concentric muscular failure. The total number of repetitions performed across sets in the bench press followed a similar pattern for TRT and ART, with significant reductions between sets 3, 4, and 5 compared with set 1 (p < 0.05). There was a significant difference for set 4 between conditions with a lower number of repetitions performed in the TRT. The volume load was significantly higher for ART when compared with TRT. TRT showed significant reductions in BP after 10-, 40-, and 60-minute postexercise and when compared with CON after 40- and 60-minute postexercise. However, the effect size illustrated large reductions in systolic BP during recovery in both methods. Thus, it is concluded that both methods reduced postexercise BP.
Metabolic Effects of Reduced Volume Sprint Interval Training During and Postexercise
Authors: McCarthy Seth F. , McKie Greg L. , Howe Greg J. , Vanderheyden Luke W. , Hazell Tom J.
Published: April 2024

McCarthy, SF, McKie, GL, Howe, GJ, Vanderheyden, LW, and Hazell, TJ. Metabolic effects of reduced volume sprint interval training during and postexercise. J Strength Cond Res 38(5): 891–897, 2024—It is unclear what dose of sprint-interval training exercise (exercise volume) is required to derive beneficial metabolic effects during and postexercise. Therefore, we examined how reducing the volume of sprint interval training (SIT) from 2 minutes of “all-out” efforts (8 bouts) to 1.5 minutes (6 bouts) and 1 minute (4 bouts) affected during and postexercise metabolism. Fourteen recreationally active males (age: 25 ± 3 years; body mass index: 25.1 ± 3.1 kg·m−2) had gas exchange measured during and following (3 h) 4 experimental sessions: (a) no-exercise control (CTRL), (b) 8 × 15 SIT (2 minutes exercise), (c) 6 × 15 minutes SIT (1.5 minutes exercise), and (d) 4 × 15 SIT (1 minute exercise). All SIT protocols were 15 seconds “all-out” running efforts with 2 minutes recovery (4, 6, or 8 bouts). Changes were considered important if p < 0.100 and the effect size was ≥medium. During exercise, oxygen consumption (V̇o
2; L) was different between protocols (p < 0.001, d > 2.98) and greater than CTRL (p < 0.001, d > 2.12); however, the rate of O2 consumption (L·min−1) was similar between protocols (p = 0.479,

= 0.055). Total V̇o
2 (L) postexercise was elevated following all conditions compared with CTRL (p < 0.003, d > 1.25). Overall session V̇o
2 was different in each condition (p < 0.001, d > 1.89). Fat oxidation was elevated postexercise following all SIT protocols compared with CTRL (p < 0.017, d > 0.98) with no differences between protocols (p > 0.566, d < 0.48). Our results suggest reducing the number of all-out 15 seconds bouts during a SIT session from 8 to 6 or 4 had no differential effects on postexercise metabolism and differences during exercise were due to the longer duration of exercise.
Army Combat Fitness Test Scores Moderate Cognitive Function Improvements After a Ruck March: A Hierarchical Linear Model Approach
Authors: Sax van der Weyden Megan , Merrigan Justin J. , Newman Kayleigh , Hahn Joseph , Martin Joel
Published: April 2024

Sax van der Weyden, M, Merrigan, JJ, Newman, K, Hahn, J, and Martin, J. Army Combat Fitness Test scores moderate cognitive function improvements after a ruck march: A hierarchical linear model approach. J Strength Cond Res 38(7): 1314–1320, 2024—Heavy load carriage is a common task for military personnel and can lead to undue physical and mental fatigue. The purpose of this study was to assess effects of load carriage on cognitive function (CF) and the role individual characteristics play in CF responses. Anthropometrics/body composition, demographics, and Army Combat Fitness Test (ACFT) scores were gathered from 47 Reserve Officers' Training Corps cadets. Cadets' CF was assessed through the concentration task grid (CTG) before (preruck), immediately after (postruck), and 3 weeks after (follow-up) a 16.09- to 19.31-km ruck march. Hierarchical linear modeling was used, with α < 0.05. The final model revealed growth, or improvement, in CF from preruck to postruck with growth decelerating, but still improved, at follow-up. The load carriage bout improved CF in most cadets, with average growth from 5.67- to 7.20-grid squares found. However, postruck CF did not return to the same level as a controlled follow-up (9.69). Sex (2.46, female), familiarity with the CTG (1.99), ACFT total scores (0.009), and relative ruck mass (−0.09) were all significant predictors of postruck CF. Army Combat Fitness Test scores (0.008) were also significant predictors of the slope between preruck and postruck, such that an ACFT score 59 points above average would result in a 1-grid square greater improvement in CF postruck. The significance of ACFT scores, lower relative ruck mass, and familiarization highlights the importance physical and mental preparation for desirable CF outcomes after occupational tasks.
Calcium-Dependent Regulation of Neuronal Excitability Is Rescued in Fragile X Syndrome by a Tat-Conjugated N-Terminal Fragment of FMRP
Authors: Zhan Xiaoqin , Asmara Hadhimulya , Pfaffinger Paul , Turner Ray W.
Published: April 2024

Fragile X syndrome (FXS) arises from the loss of fragile X messenger ribonucleoprotein (FMRP) needed for normal neuronal excitability and circuit functions. Recent work revealed that FMRP contributes to mossy fiber long-term potentiation by adjusting the Kv4 A-type current availability through interactions with a Cav3-Kv4 ion channel complex, yet the mechanism has not yet been defined. In this study using wild-type andFmr1knock-out (KO) tsA-201 cells and cerebellar sections from maleFmr1KO mice, we show that FMRP associates with all subunits of the Cav3.1-Kv4.3-KChIP3 complex and is critical to enabling calcium-dependent shifts in Kv4.3 inactivation to modulate the A-type current. Specifically, upon depolarization Cav3 calcium influx activates dual-specific phosphatase 1/6 (DUSP1/6) to deactivate ERK1/2 (ERK) and lower phosphorylation of Kv4.3, a signaling pathway that does not function inFmr1KO cells. InFmr1KO mouse tissue slices, cerebellar granule cells exhibit a hyperexcitable response to membrane depolarizations. Either incubatingFmr1KO cells or in vivo administration of a tat-conjugated FMRP N-terminus fragment (FMRP-N-tat) rescued Cav3-Kv4 function and granule cell excitability, with a decrease in the level of DUSP6. Together these data reveal a Cav3-activated DUSP signaling pathway critical to the function of a FMRP-Cav3-Kv4 complex that is misregulated inFmr1KO conditions. Moreover, FMRP-N-tat restores function of this complex to rescue calcium-dependent control of neuronal excitability as a potential therapeutic approach to alleviating the symptoms of FXS.
PISTACIA TEREBINTHUS L. OIL EXTRACTION BY LIQUID and SUPERCRITICAL CARBON DIOXIDE MODIFIED WITH A CO-SOLVENT AND EVALUATION OF PHENOLIC COMPOUNDS, FATTY ACIDS PROFILE AND TOCOPHEROLS
Authors: Sür Atakan , Eyiler Kaya Esen , Vural Halil
Published: April 2024

The Pistacia terebinthus L was extracted using liquid and supercritical carbon dioxide together with a co-solvent (ethanol). The effect of different temperatures (30 and 50°C), pressure (250, 300, and 350 bar), extraction time (60 and 120 min), and different percentages of co-solvent (0, 5, and 10%) was investigated. The amount of phenolic compounds, tocopherols, and fatty acid composition was determined. HPLC, UHPLC and GC were used for analysis of phenolic compounds, tocopherols, and fatty acid composition respectively. Quercetin was the main phenolic compound. The oil was rich in unsaturated fatty acids which were between 69.68 – 75.47%. Oleic acid was the predominant unsaturated fatty acid, and the main saturated fatty acid was palmitic acid. Total tocopherol content of the oil was between 13.07-245.3 ppm and the main tocopherol was β-tocopherol. The study showed that the amount of phenolic compounds, fatty acid composition, and tocopherol content were changed according to the parameters.
Influence of biological sex on exercise-induced nuclear factor erythroid 2-related factor 2 and downstream targets
Authors: Thorley Josh , Alhebshi Abrar , Bailey Stephen J , Martin Neil R W , Bishop Nicolette C , Clifford Tom
Published: April 2024

Objective

The aim was to evaluate whether exercise induces different nuclear factor erythroid 2-related factor 2 (NRF2) responses in males and females.

Methods

Twenty-two males and females (n = 11 per group; mean (s.d.): age: 25 (6) years, height: 1.71 (0.10) m, weight: 69.6 (12.3) kg) performed 100 drop jumps and 50 squat jumps. NRF2/antioxidant response element (ARE) binding in peripheral blood mononuclear cells, glutathione peroxidase (GPX) activity, and immune markers influenced by NRF2 (interleukin 6 (IL-6), tumour necrosis factor-α (TNF-α), matrix metalloproteinase-9 (MMP-9), vascular cell adhesion molecule-1 (VCAM-1), total leukocytes, neutrophils, monocytes) were measured pre-exercise, post exercise, and 1 h post exercise.

Results

NRF2/ARE binding did not significantly alter following exercise (P = 0.59), and no sex differences were evident (P = 0.17). Similarly, GPX activity did not change post exercise (P = 0.74) and did not differ between sexes (P = 0.61). IL-6 and TNF-α did not increase post exercise (P > 0.05 for both) but were lower in females (P < 0.01 for both). MMP-9 increased post exercise (P = 0.02), but no group differences were found (P = 0.27). VCAM-1 was unchanged after exercise (P = 0.38) and did not differ between groups (P = 0.11). Total leukocytes, neutrophils, and monocytes all increased post exercise (P < 0.01 for all); neutrophils were lower (P < 0.01), and monocytes were higher (P = 0.03) in females vs males.

Conclusion

There were no sex differences in NRF2 activity at rest and in response to an exercise bout; however, several immune markers displayed sex-specific differences, independent to NRF2.

Pre-registration

Open Science Framework = osf.io/5fpvn; Thorley, J., & Clifford, T. (2022, August 12). Curcumin supplementation, exercise, Nrf2/NFkB activity. https://doi.org/10.17605/OSF.IO/C4UQ2. Identifier: osf-registrations-c4uq2-v1

Significance statement

Sex differences in NRF2 signaling were not evident, suggesting males and females may incur similar redox-specific adaptations post exercise.
Esbozo para una lectura iconográfica de los objetos artísticos marianos en Costa Rica
Authors: Bonilla Soto Carlos
Published: April 2024

This article provides an iconographic reading of the figure of Mary of Nazareth based on the description and contextualization of artistic objects in Costa Rica. The study uses only the first two levels of reading proposed by Panofsky (1987). First, the pre-iconographic description, as a practical experience that facilitates familiarization with the objects and the circumstances that surround them, and second, the iconographic analysis to trace the constitution of the world of images, stories and allegories that underlie artistic assets. The study join the different Marian titles seen in different plastic artistic supports, into three large categories: 1. Joyful Mary; 2. Glorious Mary and 3. Mary Sorrowful, which are associated with the narrative of the mysteries of the Rosary, and are also linked to the way in which the Marian cult developed from Divine Motherhood dogmas, the Assumption to heaven and the Mary’s compassion towards her Son`s death.
SEED REPRODUCTION OF DELPHINIUM GRANDIFLORUM (RANUNCULACEAE) IN THE WESTERN SIBERIA FOREST-STEPPE CONDITIONS
Authors: Гусар А.С.
Published: April 2024

В работе представлены результаты изучения сезонного развития, семенной продуктивности и состояния зародышей в зрелых семенах Delphinium grandiflorum L. Исследования проводились на протяжении двух лет (2021–2022 гг.). Растения успешно проходят все фенофазы, один генеративный побег образует 299–700 шт. семян. Впервые выявлены достоверные отличия по числу цветков и плодов на главной оси синфлоресценции и паракладиях различных порядков, а также по числу семязачатков в цветках и семян в плодах, расположенных в разных частях синфлоресценции. Показано влияние гидротермических условий вегетационных периодов на семенную продуктивность и качество семян. Наиболее благоприятными для роста и развития D. grandiflorumбыли метеоусловия 2022 года, что выражалось в раннем наступлении фенофаз, высокой семенной продуктивности и высокой степени сформированности зародышей в зрелых семенах. Это обусловлено тем, что во время бутонизации и цветения D. grandiflorum отсутствовали значительные колебания температуры воздуха и влажности. Растения D. grandiflorum перспективны для выращивания в Западной Сибири по следующим репродуктивным показателям: сезонному развитию, семенной продуктивности и развитию зародышей в семенах.

The article reports the results of the following studies: seasonal development, seed production and embryo conditions in the mature seeds of Delphinium grandiflorum L. The research was done over two years (2021–2022). The species successfully goes through all phenophases, one generative shoot forms 299–700 pcs. seeds. For the first time, significant differences were revealed in the number of flowers and fruits on the main axis of synflorescence and paracladia of various orders, as well as in the number of ovules in flowers and seeds in fruits located on different parts of synflorescence. The article presents the influence of vegetation period hydrothermal conditions on seed productivity and quality of seeds. The weather conditions of 2022 year were the most favorable for the growth and development of D. grandiflorum, which was expressed in the early beginnings of phenophases, high seed productivity, and the more developed embryos in mature seeds. This may be due to the fact that during the budding and flowering of D. grandiflorumthere were absence of significant fluctuations in air temperature and humidity. D. grandiflorum plants are promising for cultivation in Western Siberia according to the following reproductive indicators: seasonal development, seed productivity and development of embryos in seeds.
NEW SPECIES OF AGARICOID BASIDIOMYCETES FOR THE MYCOBIOTA OF SIBERIA AND RUSSIA
Authors: Горбунова И.А. , Зибзеев Е.Г.
Published: April 2024

На основании исследований биоты агарикоидных базидиомицетов Южной Сибири приводятся сведения о морфологии, распространении и экологической приуроченности для 3 новых для микобиоты Сибири видов агарикомицетов: Hemimycena tortuosa (P.D. Orton) Redhead, Entoloma formosum (Fr.) Noordel., E. sublaevisporum Vila, Noordel. et O.V. Morozova, обнаруженных в степных и лесных сообществах Западной и Восточной Сибири. Вид Hemimycena tortuosa также является новым для территории России.

Based on studies of the biota of agaricoid basidiomycetes in Southern Siberia, information is provided on the morphology, distribution and ecological association of 3 new agaricomycete species for the mycobiota of Siberia: Hemimycena tortuosa (P.D. Orton) Redhead, Entoloma formosum(Fr.) Noordel., E. sublaevisporum Vila, Noordel. et O.V. Morozova, found in steppe and forest communities of Western and Eastern Siberia. The species Hemimycena tortuosa is also new to Russia.The specimens of this species are kept in the Herbarium of M.G. Popov of the Central Siberian Botanical Garden SB RAS (NSK). Key words: Agaricales, Entolomataceae, Mycenaceae, agaricoid basidiomycetes, mycological findings, Kemerovo Region, Trans-Baikal Territory, Russia.
Haiti resurging epidemics: Its potential to transition to endemic status
Authors: L Tulp Orien , Sainvil Frantz , Sanon Valentine , A Sciranka Andrew , Karunyasopon Vorachoat , A Awan Aftab , P Einstein George
Published: April 2024

The island nation of Haiti had been Cholera free for over a century prior to the 2010 earthquake which left over 1 million inhabitants homeless, when a key community water source became inadvertently contaminated with the causative organism, V. cholerae (El Toro strain 01) soon after the earthquake. The infectious organism was apparently transmitted via well intentioned Nepalese aid workers visiting the Island. During the 2010-2018 outbreak, over 819,000 people were treated for cholera, resulting in nearly 10,000 deaths. With assistance from the CDC, the U.S. Agency for International Development, and implementing partners including the Pan American Health Organization to further expand epidemiologic and public health initiatives, Haiti was once again declared cholera free in February 2022, having no new cases for over 3 years; however, by Sept 2022 new cases were once again reported, ultimately affecting over 20,000 additional mostly Haitian residents, geographically centered around the Port au Prince area, and in 285 additional deaths from the second wave of the Cholera epidemic. This was followed by over 1150 additional deaths by mid-December 2023 and the designation as a Grade 3 Emergency Hazard Status by the WHO. Because of the high potential for asymptomatic carriers of cholera to develop following a widespread epidemic, additional public health strategies must be vigorously employed including widespread immunization to control and minimize the continued impact of the endemic on community, regional and global wellbeing and hopefully prevent the next epidemic from occurring in Haiti or from spreading to surrounding islands and distant jurisdictions.
Detection of white spot syndrome virus in seston from a coastal ecosystem and a shrimp farm in the Gulf of California
Authors: Hakspiel-Segura Cristian , Martínez-López Aída , López-Meyer Melina , Escobedo-Urías Diana Cecilia
Published: April 2024

Three molecular assays were used to detect and quantify white spot syndrome virus (WSSV) in DNA extracted from seston size-fractioned (0.02, 0.2, 1.2, and 20 μm) samples collected from a coastal lagoon and an adjacent shrimp farm. From 107 DNA extracts, only two from one sample tested positive for WSSV with nested PCR in the 1.2 and 20 μm fractions. These results were confirmed by a semi-quantitative (IQ2000TM WSSV Detection and Prevention System) and a quantitative (IQREALTM WSSV Quantitative System) detection system based, based, respectively, on nested PCR and real-time PCR. A first viral load reference value (6.54 × 104 WSSV copies/mL) was established in a seston size fraction (1.2−20 μm). The results suggest that WSSV could be associated with both resuspension of fine clays and silts, and nanoplankton and organic colloids during infectious events.
Factorial analysis of road infrastructure related to traffic accidents occurred in Neiva in the years 2017-2018
Authors: Parra-Quintero Juan David , Barrera-Cardozo José Adel , Ramírez-Soto Primitivo
Published: April 2024

The transportation sector has been fundamental in Colombia and faces serious consequences in terms of traffic accidents. This paper examines the relationship between accidentability and most outstanding road infrastructure factors in ten urban stretches of Neiva in the period 2017-2018, following the inclusion and exclusion criteria of the International Road Assessment Program (IRAP) for developing countries in order to characterize the state of road infrastructure of the selected points. The results showed that the central sections of the city tend to be related to the day, time, type of vehicle and victim, attribute and direction of the road. The motorcyclist was the road actor most vulnerable to injuries and fatalities, Saturday and 8:00 am was where more crashes occurred. The road infrastructure factors contributing to accidents highlight the relevance of the environment in the city.
Smart sensors/actuators based in amorphous nanostructures, according to enhance robotic arms energy transmission
Authors: Calderón-Chavarri Jesús Alan , Barriga Benjamín , Tafur Julio C. , Jiménez Fernando , Lozano John , Lozano Hugo , Risco Rusber , Gallo Dante J.
Published: April 2024

This article mainly analyzes the correlation between the carrier energy in robotic arms, according to enhance its performance. This task is achieved because of the sensors/actuators based on nanostructures properties: short response time and high robustness, which proportionated the possibility to execute intricate instructions by the control subsystem of the robotic arm. Therefore, the instructions executed by the controller are supported by a polynomial design, this algorithm helped to evaluate every response signal as a consequence of the main control system, which was consequently by the short response time from the main sensors “flow (carrier energy) and speed of the robotic arm”, moreover, the advantage of the proposed system is given by the extra time obtained also to verify the stability of the robotic arm based in Lyapunov models correlated with Lagrange, as well as every equations were solved and organized by neural network.
LoRa-based IoT platform for remote soil parameter monitoring
Authors: Lopes Iug , Souza Barbosa Rafael , Damascena dos Santos Diego , Medrado de Melo Juliana Maria , Melo Vellame Lucas , Alves de Oliveira Eziom , Kramer Schwiderke Samuel
Published: April 2024

The objective of this work was to develop an innovative LoRa-based platform that provides a low-cost and customizable solution for real-time monitoring of soil parameters. The system architecture was based on four levels: environmental (rural), sensors and actuators, communication network, and application, with the code made available for operation. The collected data were transmitted to data collection points using LoRa technology. The application level allowed for data storage, analysis, and visualization, enabling end-users to remotely monitor and control environmental measurement operations. With LoRa technology range tests, results indicated the capability to cover a maximum area between 95 and 120 hectares in the studied areas. Additionally, the collected data were sent to ThingSpeak.com and a mobile application called Thingsview. This demonstrated the efficiency and viability of LoRa technology for industrial communication sensor and IoT applications in rural environments, offering automation, increased efficiency, and savings in human resources for environmental monitoring tasks.
Desarrollo de una Arquitectura IoT para monitoreo ambiental: integración de tecnologías de código abierto con proyección de aplicación en el sector minero
Authors: Vallejo-Sanchez Dulfary , Muñoz-García Andrés , Chaverra-Zuleta Emanuel , Correa-Casas Jader , Londoño Luis Fernando , Bustamante-Rúa Oswaldo
Published: April 2024

Este trabajo detalla el diseño y la implementación de una arquitectura de Internet de las Cosas centrada en el monitoreo de temperatura y humedad. La selección estratégica de tecnologías, como Arduino, módulos LoRa, sensor DHT11 y el microcontrolador ESP32, constituye la base del sistema. Se destaca el empleo de Python Flask para desarrollar una interfaz de usuario en la aplicación web, asegurando así una experiencia de usuario fácil y accesible. Además, se enfatiza la implementación de algoritmos modulares y medidas de autenticación para mejorar la escalabilidad y seguridad del sistema. El artículo concluye resaltando los beneficios y la eficacia de la tecnología de código abierto en la adquisición, procesamiento y monitoreo de datos en diferentes escenarios de aplicación. Se proporcionan sugerencias para futuras mejoras, con especial atención a la expansión de la visualización de datos y la monitorización ambiental. Se abordan las limitaciones y ventajas del sistema, destacando su potencial aplicación en áreas remotas o con recursos limitados. Se espera que los resultados obtenidos en este trabajo puedan ser escalados a las diferentes etapas de un proyecto minero de pequeña y mediana escala en los que se requiere monitorear parámetros ambientales que oriente la toma de decisiones, como una metodología de trabajo que esté al alcance de pequeñas agremiaciones y explotación de recursos naturales de manera sostenible.
Screen time, sleep, brain structural neurobiology, and sequential associations with child and adolescent psychopathology: Insights from the ABCD study
Authors: Zhao Yihong , Paulus Martin P. , Tapert Susan F. , Bagot Kara S. , Constable R. Todd , Yaggi H. Klar , Redeker Nancy S. , Potenza Marc N.
Published: April 2024

Background and Aims

The precise roles of screen media activity (SMA) and sleep problems in relation to child/adolescent psychopathology remain ambiguous. We investigated temporal relationships among sleep problems, SMA, and psychopathology and potential involvement of thalamus-prefrontal-cortex (PFC)-brainstem structural covariation.

Methods

This study utilized data from the Adolescent Brain Cognitive Development study (n = 4,641 ages 9–12) at baseline, Year1, and Year2 follow-up. Cross-Lagged Panel Models (CLPMs) investigated reciprocal predictive relationships between sleep duration/problems, SMA, and psychopathology symptoms. A potential mediating role of baseline Thalamus-PFC-brainstem covariation on SMA-externalizing relationships was examined.

Results

Participants were divided into discovery (n = 2,359, 1,054 girls) and replication (n = 2,282, 997 girls) sets. CLPMs showed 1) bidirectional associations between sleep duration and SMA in late childhood, with higher frequency SMA predicting shorter sleep duration (β = −0.10 [95%CI: −0.16, −0.03], p = 0.004) and vice versa (β = −0.11 [95%CI: −0.18, −0.05], p < 0.001); 2) externalizing symptoms at age 10–11 predicting sleep problems (β = 0.11 [95%CI: 0.04, 0.19], p = 0.002), SMA (β = 0.07 [95%CI: 0.01, 0.13], p = 0.014), and internalizing symptoms (β = 0.09 [95%CI: 0.05, 0.13], p < 0.001) at age 11–12; and 3) externalizing behavior at age 10-11 partially mediating the relationship between baseline thalamus-PFC-brainstem covariation and SMA at age 11–12 (indirect effect = 0.032 [95%CI: 0.003, 0.067], p-value = 0.030). Findings were replicable.

Conclusion

We found bi-directional SMA-sleep-duration associations in late childhood. Externalizing symptoms preceded future SMA and sleep disturbances and partially mediated relationships between structural brain covariation and SMA. The findings emphasize the need for understanding individual differences and developing and implementing integrated strategies addressing both sleep concerns and screen time to mitigate potential impacts on psychopathology.
Enhancing collaboration and engagement using virtual reality within site safety planning
Authors: Swallow Mark , Zulu Sam
Published: April 2024

For construction managers’ effective collaboration, communication and engagement during safety planning is essential to improve on-site efficiency and reduce risks. While the use of virtual reality (VR) has gained increased global attention in the past decade, the documentation of practical applications during active construction projects in the UK remains underdeveloped. Specifically, this includes the use of VR within on-site construction logistics management processes and its potential impacts on multidisciplinary collaboration and engagement. This study aims to bridge this gap by exploring the use of VR during practical safety and plant logistics planning workshops to capture real-world examples. Collaborating with a UK-based construction contractor, this study collected qualitative data over a series of planning workshops during a live project, involving 15 site team members of varying disciplines. Data collection included direct observations and focus groups, with the data analysed using a hybrid thematic analysis method. The results provided evidence of effective and accurate plant logistics planning with working practical examples, indicating that the use of VR had a positive impact on interdisciplinary collaboration and engagement. The results showed that the inclusion of VR tools also encouraged knowledge transfer between project teams, which led to improved confidence and engagement when conducting planning activities.
Salinity preferences of Diamondback Terrapin (Malaclemys terrapin) headstarts: A laboratory study
Authors: Dahl Erika , Banner Hanna , Vatnick Itzick
Published: April 2024

Salt marshes along the eastern coast of the USA are challenging environments due to their tidal nature,which causes constant fluctuations in the salinity levels of their brackish water. Diamondback Terrapins (Malaclemysterrapin) can inhabit these salt marshes due to their ability to tolerate highly saline water. The physiological mechanismsunderlying this ability are well known in adults, but have not been thoroughly explored in hatchlings and juveniles,which cannot grow when exposed to high salinity. We examined salinity preferences of hatchlings and juveniles in thelaboratory and concluded that hatchlings do not exhibit salinity preferences and develop this trait as juveniles.
Experimental studies of ignition and combustion of coal using plasma activation
Authors:   Kutateladze Institute of Thermophysics of the Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Butakov Evgenii B. , Abdurakipov Sergey S. ,   Kutateladze Institute of Thermophysics of the Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Kochergin Dmitriy O. ,   Kutateladze Institute of Thermophysics of the Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Vinogradov Sergey V. ,   Kutateladze Institute of Thermophysics of the Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Pochtar Anton S. ,   Kutateladze Institute of Thermophysics of the Siberian Branch of the Russian Academy of Sciences, Novosibirsk
Published: April 2024

This work presents experimental studies of a promising method of ignition and combustion of coal fuel using plasma activation. Experimental studies were carried out on a bench with a thermal power of up to 5 MW. As an experimental sample, hard coal of the GD grade was chosen selected after a ball drum mill with a sieve residue of R90 = 15%. The conditions were close to industrial ones used when lighting coal boilers. The operating range of pulverized coal flow velocities in the electric arc unit has been determined. It has been established that a stable process of ignition and further combustion of coal is possible at flow rates on the electric arc unit from 6 to 13 m/s. The experimental stand was kindled from a cold state to a temperature of 1000 °C at excess air coefficients a from 0.5 to 0.7, the kindling time did not exceed 200 seconds. Based on the experiments, CFD modeling determined whether the process conditions were met.
Заботы и дни секунд-майора Алексея Ржевского. 3-е изд.
Authors: Федюкин Игорь
Published: April 2024

В новой книге из серии «Новые источники по истории России. Rossica Inedita» представлен ранее неизвестный комплекс писем, дневниковых записей и заметок секунд-майора Ширванского полка Алексея Ивановича Ржевского за 1755–1759 гг. Документы Ржевского отражают офицерский быт и служебные реалии в тылу русской армии в годы Семилетней войны, обширные социальные контакты автора и его отношения с родственниками. Уникальным для этого времени является подробное описание Ржевским своих многочисленных болезней и методов их (само)лечения, а также эмоциональных состояний и любовных приключений. Книга адресована как историкам и культурологам, так и широкому кругу читателей.
AF & HCM meta-analysis protocol v1
Authors: Aboutorabi Max
Published: April 2024

Background: A systematic review and meta-analysis will be conducted to assess the efficacy and safety of direct oral anticoagulants (DOACs) versus vitamin K antagonists (VKAs) in patients with hypertrophic cardiomyopathy (HCM) and atrial fibrillation (AF). Methods: Studies enrolling patients with HCM and AF will be included. Primary outcomes will include thromboembolic events, major bleeds, and all-cause mortality, while secondary outcomes will include intracranial hemorrhages and cardiovascular death. Results: We will search OVID MEDLINE, Cochrane CENTRAL, and EMBASE up to April 2024. Data will be extracted and analysed using standard meta-analytic techniques. Conclusion: Our findings will provide insights into the comparative effectiveness of DOACs and VKAs in patients with HCM and AF, aiding clinical decision-making in this population.
SARS-CoV-2 nsp3 macrodomain Time-Resolved FRET peptide displacement assay v3
Authors: Barr Haim , Lahav Noa
Published: April 2024

This protocol details the Time-Resolved FRET (TR-FRET) assay for SARS-CoV-2 nsp3 macrodomain (Mac1) binding of adenosine diphosphate (ADP)–ribosylated (ADPr) peptide. This method is intended to measure the activity of Mac1 by using a specific ADPr-modified peptide that allows the detection of binding. When bound, the biotinylated-peptide and the HIS-tagged Mac1 form a proximity complex that is detected by TR-FRET using Streptavidin-Eu Cryptate and anti-HIS-XL665 as a donor/acceptor pair. Excitation of the Eu Cryptate complex at 325 nm emits a resonant energy of 625 nm which in turn excites the XL665 to emit fluorescence at 665 nm. This energy transfer occurs only when ADPr modified peptide is in sufficient proximity to Mac1 and inhibitors which displace the peptide will prevent energy transfer. Binding activity is reported as the ratio of Acceptor/Donor (Em/Em) X 10,000. ------------------------------------------------------- Experiment Concentrations (From Stock to Assay) ReagentStockLoaded into CombiFinal in assay plateUnitsHis-SARS COV2 MAC1183000 5012.5nM Substrate (Biotin-ADPr) 100000001600400nMDetection solution Streptavidin-XL665 (SA-XL)10.250.125%MAb Anti-6HIS-Eu cryptate Gold1000.250.125%Assay buffer HEPES pH=7.025025 25 mMNaCl200 20 20 mMBSA0.50.050.05%Tween 20 0.50.050.05%HTRF PPI Europium Detection Buffer1001010 % ------------------------------------------------------- Compound Plate Design for Dose Response: Total Assay Volume: 16 µL Compounds Top Assay Concentration: 100 µM Dilution Factor: 3 Dose Response Points: 10 Number of Replicates: 2 Backfill with DMSO: Yes Compounds Plate Design for 2-Point Assay: Total Assay Volume: 16 µL Compounds Assay Concentration: 100 µM and 50 µM Dilution Factor: 2 Dose Response Points: 2 Number of Replicates: 2 Backfill with DMSO: Yes
A method for determining the location and type of fault in transmission network using neural networks and power quality monitors
Authors: Šipoš Mario , KLAIĆ Zvonimir , Nyarko Karlo Emmanuel , Fekete Krešimir
Published: April 2024

A new technique for identifying the location of a fault on a power line utilizing neural networks is presented in this paper. Specifically, the procedure involves four stages (three of which employ neural networks): gathering voltage input data via simulation, classifying the fault type, detecting the faulted line, and determining the fault position on the power line. This model was developed and tested for the IEEE 39 bus test system. Input voltages are obtained using DigSILENT PowerFactory software in which a set of three-phase and single-phase short circuits are simulated. Not voltages from all buses are used for the subsequent stages, only voltages from the optimally placed 12 buses in the IEEE 39 bus test system are used. In the second step, the first neural network is employed in order to classify the fault type – single-phase or three-phase. In the second stage, another neural network is used to determine the faulted line and in the third stage, the last neural network is developed to determine the fault position on the faulted line.
Walnut shells as a promising sorbent for treatment of urban surface wastewater
Authors: Samodolova Olesya A. , Ulrikh Ulrikh V. , Lonzinger Tatiana M. , Golovina Svetlana G.
Published: April 2024

Food industry is one of the most stable sectors of the global market demonstrating the annual growth of the production output, including in the walnut kernel production, with subsequent generation of waste as a result of its processing. The use of walnut shells as a material for production of sorbents is a promising method of waste disposal. The goal of this research is to evaluate the sorption capacity of walnut shells to clean surface wastewater from urban territories. The object of research was the surface wastewater from urban territories. OPTIMA 2100DV spectrometer (Perkin Elmer), pH-150MI microprocessor pH meter, and JEOL JSM-6460 LV scanning electron microscope were used during the research. The obtained experiment data have shown that walnut shells are a promising material for production of sorbents.
Features of modern spatial development of the kama agglomeration
Authors: Khakimova Tansylu S. , Zakirova Yulia A.
Published: April 2024

The article examines strategic documents, regulatory legal acts of the federal, regional and local levels in order to identify priority areas of project activities in relation to the Kama agglomeration, examines the current urban situation on the basis of cartographic data, data from state statistical agencies, field studies. The possibilities and limitations of the territorial and spatial development of the Kama agglomeration are determined. Today, the Kama agglomeration is formed on the basis of two core cities: the cities of Naberezhnye Chelny and Nizhnekamsk. The purpose of the study is to determine the features of the modern territorial and spatial development of the Kama agglomeration.
A VIEW OF THE NATURE AND MEANING OF HUMAN EXISTENCE IN CHINESEISED MARXISM
Authors:   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, Turenko Vitalii
Published: April 2024

B a c k g r o u n d . Sinicized Marxism involves the utilization of Marxist theory to address issues specific to China and the transformation of China's rich practical experience into theory, combined with Chinese history and traditional culture. This can be observed in the context of the exploration of philosophical-anthropological issues. M e t h o d s . The key methods employed to address the outlined tasks were comparative and dialectical. The use of the comparative method allowed for the identification of commonalities and differences in the understanding of the human problem in Western European and contemporary Chinese philosophy. The inclusion of the dialectical method helped reveal contradictions in the explication of the nature and meaning of human existence by various contemporary Chinese thinkers. R e s u l t s . It has been found that contemporary Chinese thinkers perceive a dichotomy in human nature–social and natural. Considering not only Karl Marx's works but also those of other Western philosophers, particularly Immanuel Kant, Marxist philosophers in China emphasize the social component of human nature, which is crucial to individuality. C o n c l u s i o n s . It is argued that Sinicized Marxism, like its Soviet counterpart, also incorporates the concept of the "new man" whose life's purpose is to exist exclusively based on the principles and values of Marxist philosophy. The formation and functioning of this concept are influenced by extensive discussions regarding the role of humans in history. Sinicized Marxism emphasizes that each individual, living in society, pursues their own specific values and, guided by them, acts to achieve their realization. Although these goals and actions are diverse, varied, and contradictory, there is a common essence underlying this mass of individual goals and actions. Accordingly, contemporary Chinese thinkers assert that within a specific historical society, people are integrated independently of their will and desire into a unique system of material relations that constitutes their social existence. As a result, they are in a certain way connected within each formation and with the means of production. Production relations organize people, stimulate their activities, generate certain relationships and dependencies among social groups. Common interests, reflected in consciousness, more or less consciously, unite people, motivating them to strive for the realization of certain social goals. The thesis is substantiated that although Sinicized Marxism emphasizes the social goal of human life, it also encompasses considerations about the existential aspect, manifested in living for self-improvement and for the sake of others.
SEARCH FOR A NEW METAPHYSICS: THE CONCEPT OF PHILOSOPHICAL COSMOLOGY OF GILLES DELEUZE
Authors:   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, Prykhodko Volodymyr
Published: April 2024

B a c k g r o u n d . The purpose of this article is to reveal the concept of philosophical cosmology as a new metaphysics based on ideas proposed by Gilles Deleuze in his work "The Logic of Sense". For this, it is necessary to get rid of the interpretation of philosophical cosmology as an exclusively philosophical-scientific discipline and begin to perceive it as a basic theory of order that can replace ontology. To implement this strategy, Deleuze turns to the ideas of the philosophy of Stoicism. This choice is primarily due to the first concept of sense (lekton theory), as well as the doctrine of space (khora) and the living, renewable cosmos (palingenesia). The relevance of Stoicism is reinforced by the historical and civilizational perspective, where the emergence and renewal of interest in the Stoics' thoughts corresponds to periods of violent crisis. M e t h o d s . The hermeneutic analysis of the works of Gilles Deleuze, the Stoics and researchers of Stoicism makes it possible to include the concept of philosophical cosmology in the foundations of spatial phenomenology which is implemented in the topographic method of researching its main subject, which is the world, and culture in particular. R e s u l t s . In this way, the philosophical cosmology of Gilles Deleuze provides grounds for a better understanding of the cultural and intellectual situation of today, which includes information overload and the essential uncertainty of the prospects of civilizational development, in which culture appears more as a spontaneous performative formation than a logical projected system of valid norms and rules. C o n c l u s i o n s . That is why philosophical cosmology has applied value, as it responds to the spatial and performative turn in modern culture.
The effect of overweight and obesity on the severity of manifestations of chronic nonbacterial prostatitis with an inflammatory component
Authors: Amelchenko Andrei  A. , Vinnik Yurii Yu.
Published: April 2024

BACKGROUND: Chronic prostatitis is one of the most common urological diseases of young and middle-aged men. The variety of pathogenetic mechanisms and clinical manifestations, the tendency to recurrence necessitates the search for new methods of examination and monitoring of this disease.
AIM: To identify the characteristics of the clinical manifestations of chronic non-bacterial prostatitis with an inflammatory component in men of the first period of adulthood, depending on the body mass index.
MATERIALS AND METHODS: A comprehensive urological examination was carried out on 150 men with CNVC in the first period of adulthood, aged 22 to 35 years. All patients were assessed for hormonal status, as well as anthropometric parameters.
RESULTS: Men with normal body mass index had milder clinical symptoms of prostatitis compared with overweight and obese patients. The results of laboratory studies demonstrated a more pronounced inflammatory process and dysfunction of the prostate in patients with a higher body mass index. Analysis of hormonal status revealed high levels of total and free testosterone and low levels of estradiol in men with normal body mass index. The content of sex hormone-binding globulin was significantly lower in obese patients. Overweight and obese men also had larger prostate volume according to TRUS.
CONCLUSIONS: More severe manifestations of prostatitis are associated with an increase in body mass index.
Overactive bladder, inflammation and urinary tract infection: pathogenetic parallels
Authors: Kuzmin Igor  V. , Slesarevskaya Margarita N. , Romikh Viktoria V.
Published: April 2024

The review is devoted to modern ideas about the role of inflammation and urinary tract infection in the pathogenesis of overactive bladder. The molecular mechanisms of the mechanosensory function of the urothelium and the influence of bacterial colonization of the urothelium on it are described in detail. It has been shown that infectious inflammation, even in the absence of clinical symptoms, enhances the urothelial response to stretching and increases the excitability of afferent nerves. Bladder hypersensitivity and increased detrusor activity are pathogenetic basis for the development of overactive bladder. Data on the relationship between urinary infection and refractory overactive bladder are presented. The feasibility of conducting extended microbiological studies in patients with overactive bladder , especially when standard therapy is ineffective, has been demonstrated. A pathogenetic rationale for prescribing anti-inflammatory and immunoactive drugs to patients with overactive bladder is presented.
Evaluation of the quality of life in patients with meningiomas of the craniovertebral junction using a developed questionnaire in a neurosurgical clinic
Authors: Shimanskiy Vadim N. , Sultanov Ruslan A. , Yusupova Dzhamilya G. , Poshataev Vladimir K. , Zimin Alexey A. , Tanyashin Sergey V. , Zaytsev Alexandr B. , Karnaukhov Vasiliy V. , Suponeva Natalia A.
Published: April 2024

BACKGROUND: A validated tool for assessing the quality of life specific to a particular disease has not yet been developed. Previous studies only partially investigated the quality of life of patients with craniovertebral junction meningiomas and did not include the entire spectrum of functional disorders in this disease.
AIM: To develop and validate a questionnaire to assess the quality of life of patients with craniovertebral junction meningiomas.
MATERIALS AND METHODS: A retrospective and prospective study of 119 patients with craniovertebral junction meningiomas was conducted before and after surgical and combined (surgical removal of the tumor followed by radiation therapy) treatment using a validated questionnaire developed.
RESULTS: A quality of life questionnaire for patients with craniovertebral junction meningiomas was developed and validated. Determining the internal consistency of the scale showed that the Cronbach alpha coefficient was α=0.78 (p 0.001), confirming its sufficient level. In analyzing the sensitivity of the questionnaire, the estimates before and after surgery did not differ significantly (p=0.62, t-criterion).
CONCLUSIONS: This study developed the first quality of life questionnaire worldwide for patients with craniovertebral junction meningiomas. In summary, this questionnaire is not able to reflect the dynamics of the quality of life.