bluuebunny/crossref_metadata_2025 huggingface dataset:
A smartphone application to enhance bowel preparation for first-time colonoscopy: a randomized controlled study
Authors: Pattarapuntakul Tanawat , Kanchanasuwan Thanyaporn , Kaewdech Apichat , Wong Thanawin , Netinatsunton Nisa , Chalermsuksant Nalerdon , Sripongpun Pimsiri
Published: April 2024

Background and aims

Colonoscopy is an essential cancer screening tool; however, bowel preparation is a multifaceted process that involves several steps. Proper preparation is crucial for a successful colonoscopy in terms of diagnostic accuracy and procedural safety. We evaluated the performance of a smartphone application with bowel preparation instructions on individuals undergoing their first colonoscopy.

Methods

In this randomized, prospective, endoscopist-blinded study, participants were scheduled to undergo their first colonoscopy between January 2020 and January 2022. The study protocol was registered at Thai Clinical Trials Registry (TCTR20190928002). They were randomly assigned to the smartphone education application (APP) or the standard education (control) group. The Boston Bowel Preparation Scale (BBPS) score, polyp detection rate (PDR), and adenoma detection rate (ADR) were compared. Factors associated with excellent bowel preparation were also evaluated.

Results

In total, 119 patients (APP group, n = 57; control group, n = 62) underwent their first colonoscopy. The mean BBPS score and proportion of excellent bowel preparation (BBPS≥8) were significantly higher in the APP group than in the control group. Smartphone application-guided bowel preparation achieved a higher proportion of adequate and excellent bowel preparation scores, was associated with other quality indicators, and achieved the target ADR, cecal intubation rate, and adequate withdrawal time.

Conclusion

This application may be a user-friendly option to improve the first-time colonoscopy experience, resulting in effective screening of colorectal cancer.

Clinical trial registration

The study protocol was registered at Thai Clinical Trials Registry (TCTR20190928002).
Awake venovenous extracorporeal membrane oxygenation and survival
Authors: Rottmann Felix A. , Zotzmann Viviane , Supady Alexander , Noe Christian , Wengenmayer Tobias , Staudacher Dawid L.
Published: April 2024

Objectives

Deep sedation on the ICU is linked to poor outcome. This study investigated the link between Richmond Agitation-Sedation Scale (RASS) and outcome in venovenous extracorporeal membrane oxygenation (V-V ECMO).

Methods

We performed a secondary analysis of a single-center V-V ECMO cohort. RASS was used as a surrogate measure of sedation depth, patients with a score ≥ −1 were considered awake. V-V ECMO durations below 24 h were excluded. Primary endpoint was 30-day survival. Secondary endpoints were hospital survival and weaning from both ventilator and ECMO therapy.

Results

A total of 343 patients were reanalyzed. The median age was 55 years and 52.2% (179/343) survived for 30 days after ECMO cannulation. Median duration of ECMO was 7.9 (4.7–15.0) days and the median duration of mechanical ventilation after ECMO cannulation was 11.8 (6.7–23.8) days.

In the whole cohort, median RASS on day one and seven after ECMO were − 4 (−4 to −1) and − 3 (−4 to 0), respectively. ECMO survivors consistently had significantly higher RASS scores during the first 7 days of ECMO compared to non-surviving patients (p < 0.01). On day two after ECMO, survival of awake patients (i.e., RASS ≥-1) was significantly better compared to sedated [i.e., RASS −4 to −2; OR 2.20 (1.28–3.71), p < 0.01] or unresponsive patients [i.e., RASS -5; OR 2.27 (1.15–4.64), p = 0.02]. The survival benefit of awake ECMO was consistent from day two to seven. Patients awake at least once during ECMO showed higher 30-day survival rates [64.4% vs. 39.6%, OR 2.75 (1.77–4.24), p < 0.01].

Conclusion

In this retrospective study, awake patients on V-V ECMO showed higher 30-day survival rates compared to sedated or unresponsive patients. These data should encourage further research on awake V-V ECMO.
Survival dynamics of stick insect and the impact of environmental factors on natural fungal infection during the rainy season
Authors: Min Donggyu , Shin Soobin , Lee Noh-Hyun , Baek Min Jeong , Park Sun-Jae , Kim Kwang-Hyung , Son Hokyoung , Jung Jong-Kook
Published: April 2024

Phasmatodea, commonly known as stick insects, are recognized as noteworthy pests globally, impacting agriculture and forest ecosystems. Among them, the outbreak of Ramulus mikado has emerged as a notable concern in East Asian forests. Recently, Metarhizium phasmatodeae has been identified as utilizing stick insects as hosts. We have observed evidence of this entomopathogenic fungus infecting stick insects. Given the increase in these occurrences during the rainy period, this study investigated the relationship between the survival of R. mikado and the M. phasmatodeae infection during the rainy seasons of 2022 and 2023. We collected stick insects in two representative forests of the Republic of Korea and examined insect survival, fungal infection, and various environmental factors. No infections were detected in specimens collected in June before the rainy season, but from July onwards, both the mortality of R. mikado and the fungal infection substantially increased. By the last sampling date of each year, 75% (2022), 71.4% (2023) of the specimens were infected, and over 90% of the total individuals succumbed as a result. Fungi isolated from deceased R. mikado were successfully identified as M. phasmatodeae using morphological and taxonomic approaches. Various statistical analyses, including principal component analysis and modeling, revealed a robust association between fungal infection and the survival of stick insects. The results highlight the correlation between mass deaths of stick insects and fungal infection, particularly during the summer rainy season. These findings offer valuable insights for forecasting R. mikado population in the upcoming year and developing effective pest control strategies.
Features of bacterial and fungal communities in the rhizosphere of Gastrodia elata cultivated in greenhouse for early harvest
Authors: Khanh Nguyen Van , Dutta Swarnalee , Kim Chang-Su , Lee Yong Hoon
Published: April 2024

Symbiotic microbes are essential for developing and growing Gastrodia elata, an achlorophyllous orchid of high medicinal value. Recently, the cultivation of G. elata in greenhouses has been adopted in Korea to produce mature tubers in a short time. However, no studies have been conducted on the microbial community structure of G. elata cultivated in greenhouse environments. Therefore, we analyzed the temporal features of bacterial and fungal communities in the rhizosphere of G. elata at the juvenile [JT; 2 months after sowing (MAS)], young (YT; 6 MAS), and mature (MT; 11 MAS) tuber stages using culture-dependent and high-throughput sequencing technology. The richness and diversity of the bacterial and fungal communities decreased with tuber growth of G. elata. The symbiotic fungi Mycena sp. and Armillaria sp. as well as tuber extract inhibited the growth of various soil-inhabiting fungal and bacterial strains, indicating that G. elata and its symbiotic fungi play important roles in the selection of rhizosphere microbes. Mortierella rishikesha was the most abundant fungal species in the rhizosphere. We also identified the microorganisms potentially beneficial for G. elata development during greenhouse cultivation. Tubers and symbiotic fungi actively exert selective pressure on rhizosphere microbes, influencing the diversity and abundance of bacterial and fungal communities as G. elata grows. This study is a first report on the temporal microbial community structure of G. elata cultivated in greenhouse. The results on the associated microbiome of G. elata will help understand their beneficial interactions with G. elata and contribute to improvement in cultivation.
A 3D pseudo-continuous arterial spin labeling study of altered cerebral blood flow correlation networks in mild cognitive impairment and Alzheimer's disease
Authors: Li Meng , Zhu Tianjia , Kang Yan , Qi Shouliang
Published: April 2024

Objective

To investigate the abnormalities of the three-dimensional pseudo-continuous arterial spin labeling (3D PCASL) based cerebral blood flow (CBF) correlation networks in mild cognitive impairment (MCI) and Alzheimer's disease (AD).

Methods

3D PCASL images of 53 cognitive normal (CN) subjects, 43 subjects with MCI, and 30 subjects with AD were acquired from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database. Whole-brain CBF maps were calculated using PCASL and proton density-weighted images (PDWI). The 246 regional CBF values, including the cortex and subcortex, were obtained after registering the Brainnetome Atlas to the individual CBF maps. The Pearson correlation coefficient between every two regions across subjects was calculated to construct the CBF correlation network. Then the topologies of CBF networks with regard to global properties (global network efficiency, clustering coefficient, characteristic path length, and small-world properties), hub regions, nodal properties (betweenness centrality, BC), and connections were compared among CN, MCI, and AD. Significant changes in the global and nodal properties were observed in the permutation tests, and connections with significant differences survived after the z-statistic and false discovery rate (FDR) correction.

Results

The CBF correlation networks of CN, MCI, and AD all showed small-world properties. Compared with CN, global efficiency decreased significantly in AD. Significant differences in nodal properties and a loss of hub regions are noted in the middle temporal lobe in both MCI and AD. In the frontal lobe, BC is reduced in MCI while it is increased in the occipital lobe in AD. The identified altered hub regions with significant differences in MCI and AD were mainly distributed in the hippocampus and entorhinal cortex. In addition, disrupted hub regions in AD with significantly decreased connections were mainly found in the precuneus/posterior cingulate cortex (PCC) and hippocampus-cortical cortex.

Conclusions

Noninvasive 3D PCASL-based CBF correlation networks are capable of showing changes in topological organization in subjects with MCI and AD, and the observed disruption in the topological organization may underlie cognitive decline in MCI and AD.
Factors predicting recanalization following stent-assisted coil embolization of unruptured intracranial aneurysms with long-term follow-up
Authors: Won Yu Deok , Kim Young Deok , Ban Seung Pil , Kwon O-Ki
Published: April 2024

Objective

Stents have been widely used for coil embolization for intracranial aneurysms. Few studies have analyzed the risk factors of recanalization through long-term follow-up observation of only stent-assisted coiling. We analyzed the risk factors for recanalization through long-term observations.

Methods

A total number of 399 unruptured aneurysms treated by stent-assisted coil embolization between 2003 and 2016 in a single institution were analyzed for determining the factors associated with recanalization including the patient characteristics, aneurysms, and procedural variables. All patients underwent angiographic follow-up with digital subtraction angiography or magnetic resonance angiography at 24 months or more following the procedure.

Results

Recanalization occurred in 8%. The mean time for the recanalization was 21.1 ± 14.0 months (range, 5–51 months). The receiver operating characteristic curve analysis indicated areas under the curve for a maximum aneurysm size of 0.773 (cut-off, 6.415 mm). Multivariate analysis revealed that the maximum aneurysm size and parent artery curvature at which the aneurysm developed were significantly associated with recanalization. In parent artery curvature, the bifurcation group (OR, 9.02; 95% CI, 2.53–32.13; p = 0.001) and the convex group (OR, 3.68; 95% CI, 1.17–11.50; p = 0.025) were independent predictors of recanalization compared with the straight group.

Conclusion

The maximum aneurysm size and parent artery curvature are risk factors associated with recanalization in stent-assisted coil embolization.
Unilateral biportal endoscopy vs. open decompression for lumbar epidural lipomatosis-cohort study using a prospective registry
Authors: Tan Bing , Zheng Yu-hao , Lei Chao , Ouyang Jian-yuan , Wen Yan-bo , Shi Zhuo-hua , Yang Qi-Yuan
Published: April 2024

Objective

This study aimed to compare the outcomes of unilateral biportal endoscopy, unilateral laminectomy bilateral decompression (UBE-ULBD), and open lumbar decompression (OLD) in patients with lumbar epidural lipomatosis (LEL).

Methods

This prospective observational study was conducted from March 2019 to May 2022 and encompassed 33 patients with LEL who underwent lumbar decompression. The study included 15 cases of UBE-ULBD decompression and 18 cases of open decompression, which were followed up for 1 year. The baseline characteristics, initial clinical manifestations, and surgical details [including estimated blood loss (EBL) and preoperative complications] of all patients were recorded. Radiographic evaluation included the cross-sectional area (CSA) of the thecal sac and paraspinal muscles on MRI. Clinical results were analyzed using the Short Form-36 Score (SF-36), the Numeric Pain Rating Scale (NRS) for lumbar and leg pain, creatine kinase, the Roland and Morris Disability Questionnaire (RMDQ), and the Oswestry Disability Index (ODI).

Results

The dural sac CSA increased considerably at the 1-year postoperative follow-up in both groups (p < 0.001). The operative duration in the OLD group (48.2 ± 7.2 min) was shorter than that in the UBE-ULBD group (67.7 ± 6.3 min, p < 0.001). The OLD group (97.2 ± 19.8 mL) was associated with more EBL than the UBE-ULBD group (40.6 ± 13.6 mL, p < 0.001). The duration of hospitalization in the OLD group (5.4 ± 1.3 days) was significantly longer compared with the UBE-ULBD group (3.5 ± 1.2 days, p < 0.01). The SF-36, NRS, RMDQ, and ODI scores improved in both groups postoperatively (p < 0.001). Serum creatine kinase values in the UBE-ULBD group (101.7 ± 15.5) were significantly lower than those in the OLD group (330.8 ± 28.1 U/L) 1 day after surgery (p < 0.001). The degree of paraspinal muscle atrophy in the UBE-ULBD group (4.81 ± 1.94) was significantly lower than that in the OLD group (12.15 ± 6.99) at 1 year (p < 0.001).

Conclusion

UBE-ULBD and OLD demonstrated comparable clinical outcomes in treating LEL. However, UBE-ULBD surgery was associated with shorter hospital stays, lower rates of incision infection, lighter paravertebral muscle injury, and lower EBL than OLD surgery. Consequently, UBE-ULBD can be recommended in patients with LEL if conservative treatment fails.
Early enteral nutrition with exclusive donor milk instead of formula milk affects the time of full enteral feeding for very low birth weight infants
Authors: Wang Min , Gong Xiaohui , Yu Lianhu , Song Feifei , Li Dan , Fan Qiaoling , Zhang Ting , Yan Xueming
Published: April 2024

This study investigated the effects of exclusive donor milk or formula in the first 7 days after birth, on the time to full enteral feeding, growth, and morbidity of adverse events related to premature infants. This was a retrospective study carried out from July 2014 to December 2019 at the Department of Neonatology of Shanghai Children’s Hospital. All infants with a birth weight < 1,500 g and a gestational age ≤ 32 who received exclusive donor milk or formula in the first 7 days after birth were included in this study. The time to full enteral feeding (defined as 150 mL/kg) in the donor milk group was significantly shorter than in the formula group (18 vs. 22 days, p = 0.01). Donated breast milk was also associated with a lower incidence of NEC (4.4 vs. 7%, p < 0.01), ROP (3.8 vs. 13.2%, p < 0.01), and culture-confirmed sepsis (11 vs. 22.6%, p < 0.01). Using donated breast milk instead of current formula milk for early enteral nutrition can shorten the time to full enteral feeding and reduce the incidence of NEC, ROP, and sepsis.
The artificial sweetener neotame negatively regulates the intestinal epithelium directly through T1R3-signaling and indirectly through pathogenic changes to model gut bacteria
Authors: Shil Aparna , Ladeira Faria Luisa Maria , Walker Caray Anne , Chichger Havovi
Published: April 2024

Introduction

Recent studies have indicated considerable health risks associated with the consumption of artificial sweeteners. Neotame is a relatively new sweetener in the global market however there is still limited data on the impact of neotame on the intestinal epithelium or the commensal microbiota.

Methods

In the present study, we use a model of the intestinal epithelium (Caco-2) and microbiota (Escherichia coli and Enterococcus faecalis) to investigate how physiologically-relevant exposure of neotame impacts intestinal epithelial cell function, gut bacterial metabolism and pathogenicity, and gut epithelium-microbiota interactions.

Results

Our findings show that neotame causes intestinal epithelial cell apoptosis and death with siRNA knockdown of T1R3 expression significantly attenuating the neotame-induced loss to cell viability. Similarly, neotame exposure results in barrier disruption with enhanced monolayer leak and reduced claudin-3 cell surface expression through a T1R3-dependent pathway. Using the gut bacteria models, E. coli and E. faecalis, neotame significantly increased biofilm formation and metabolites of E. coli, but not E. faecalis, reduced Caco-2 cell viability. In co-culture studies, neotame exposure increased adhesion capacity of E. coli and E. faecalis onto Caco-2 cells and invasion capacity of E. coli. Neotame-induced biofilm formation, E.coli-specific Caco-2 cell death, adhesion and invasion was identified to be meditated through a taste-dependent pathway.

Discussion

Our study identifies novel pathogenic effects of neotame on the intestinal epithelium or bacteria alone, and in co-cultures to mimic the gut microbiome. These findings demonstrate the need to better understand food additives common in the global market and the molecular mechanisms underlying potential negative health impacts.
Case Report: Efficacy, safety, and favorable long-term outcome of early treatment with IL-1 inhibitors in a patient with chronic infantile neurological cutaneous articular (CINCA) syndrome caused by NLRP3 mosaicism
Authors: Costagliola Giorgio , D’Elios Sofia , Cappelli Susanna , Massei Francesco , Maestrini Giulia , Beni Alessandra , Peroni Diego , Consolini Rita
Published: April 2024

Chronic infantile neurological cutaneous articular (CINCA) syndrome is an autoinflammatory disease encompassed in the group of cryopyrin-associated periodic syndromes (CAPS). Patients suffering from CINCA have an elevated risk of developing chronic sequelae, including deforming arthropathy, chronic meningitis, neurodevelopmental delay, and neurosensorial hearing loss. The diagnosis of CINCA presents several difficulties, as the clinical phenotype could be difficult to recognize, and almost half of the patients have negative genetic testing. In this paper, we describe the case of a patient presenting with the typical phenotype of neonatal-onset CINCA who resulted negative for NLRP3 mutations. Based on the clinical judgment, the patient underwent treatment with anti-interleukin-1 (IL-1) agents (anakinra and, later, canakinumab) resulting in a complete clinical and laboratory response that allowed confirmation of the diagnosis. Additional genetic investigations performed after the introduction of anti-IL-1 therapy revealed a pathogenic mosaicism in the NLRP3 gene. After a 12-year follow-up, the patient has not experienced chronic complications. Although genetics is rapidly progressing, this case highlights the importance of early diagnosis of CINCA patients when the clinical and laboratory picture is highly suggestive in order to start the appropriate anti-cytokine treatment even in the absence of a genetic confirmation.
A rapid and simple non-radioactive assay for measuring uptake by solute carrier transporters
Authors: Song Kunling , Zhang Longbin , Fu Xian , Li Linfeng , Zhu Gaolin , Wu Mingjun , Zhang Wei , He Jia , Zhu Sanyong , Dang Yongjun , Liu Jun-Yan , Chen Chang , Guo Zufeng
Published: April 2024

Introduction: Solute carrier (SLC) transport proteins play a crucial role in maintaining cellular nutrient and metabolite homeostasis and are implicated in various human diseases, making them potential targets for therapeutic interventions. However, the study of SLCs has been limited due to the lack of suitable tools, particularly cell-based substrate uptake assays, necessary for understanding their biological functions and for drug discovery purposes.

Methods: In this study, a cell-based uptake assay was developed using a stable isotope-labeled compound as the substrate for SLCs, with detection facilitated by liquid chromatography-tandem mass spectrometry (LC-MS/MS). This assay aimed to address the limitations of existing assays, such as reliance on hazardous radiolabeled substrates and limited availability of fluorescent biosensors.

Results: The developed assay was successfully applied to detect substrate uptakes by two specific SLCs: L-type amino acid transporter 1 (LAT1) and sodium taurocholate co-transporting polypeptide (NTCP). Importantly, the assay demonstrated comparable results to the radioactive method, indicating its reliability and accuracy. Furthermore, the assay was utilized to screen for novel inhibitors of NTCP, leading to the identification of a potential NTCP inhibitor compound.

Discussion: The findings highlight the utility of the developed cell-based uptake assay as a rapid, simple, and environmentally friendly tool for investigating SLCs’ biological roles and for drug discovery purposes. This assay offers a safer alternative to traditional methods and has the potential to contribute significantly to advancing our understanding of SLC function and identifying therapeutic agents targeting SLC-mediated pathways.
The antitumor action of endocannabinoids in the tumor microenvironment of glioblastoma
Authors: Tang Yi , Wang Maoru , Yu Jiangping , Lv Guangyao , Wang Yu , Yu Bin
Published: April 2024

Approximately 80% of all malignant brain tumors are gliomas, which are primary brain tumors. The most prevalent subtype of glioma, glioblastoma multiforme (GBM), is also the most deadly. Chemotherapy, immunotherapy, surgery, and conventional pharmacotherapy are currently available therapeutic options for GBM; unfortunately, these approaches only prolong the patient’s life by 5 years at most. Despite numerous intensive therapeutic options, GBM is considered incurable. Accumulating preclinical data indicate that overt antitumoral effects can be induced by pharmacologically activating endocannabinoid receptors on glioma cells by modifying important intracellular signaling cascades. The complex mechanism underlying the endocannabinoid receptor-evoked antitumoral activity in experimental models of glioma may inhibit the ability of cancer cells to invade, proliferate, and exhibit stem cell-like characteristics, along with altering other aspects of the complex tumor microenvironment. The exact biological function of the endocannabinoid system in the development and spread of gliomas, however, is remains unclear and appears to rely heavily on context. Previous studies have revealed that endocannabinoid receptors are present in the tumor microenvironment, suggesting that these receptors could be novel targets for the treatment of GBM. Additionally, endocannabinoids have demonstrated anticancer effects through signaling pathways linked to the classic features of cancer. Thus, the pharmacology of endocannabinoids in the glioblastoma microenvironment is the main topic of this review, which may promote the development of future GBM therapies.
Canfranc biology platform: exploring life in cosmic silence
Authors: Hernández-Antolín Rebecca , Cid-Barrio Laura , Peña-Garay Carlos
Published: April 2024

Deep underground laboratory infrastructures have extensively been used for exploring rare events, such as proton decay, dark matter searches or neutrino interactions, taking advantage of their large muon flux reduction. However, only very few investigations have evaluated the effects of low background radiation environments on living organisms. With this purpose, the Canfranc Underground Laboratory (LSC) launched the Biology Platform in 2021, which provides lab space for approved biology experiments. Two identical laboratories have been built (underground and on surface) to replicate biology experiments under the same conditions, with the main difference being the cosmic radiation background. The access protocol to use the LSC facilities includes two open calls per year and assigned time windows for executing the experimental program, which led to the first eight approved and already running experiments. We describe the scientific program of the Canfranc Biology Platform, which explores extremophiles, viral infection, immune system, multicellularity, development or aging in cosmic silence, and the first experimental results. The Platform also allows to observe the response of life to microgravity in absence of radiation, a key condition to explore life in space.
Political trust and legitimacy crisis in the age of COVID-19: an assessment of the EndSARS protest in Nigeria
Authors: Sanusi Gumbi Khadijah , Baba Yahaya T.
Published: April 2024

The article examined the manifestations of political trust deficits associated with people's response to policy choices of Nigeria's government during the COVID-19 pandemic. Like many other states, the African states and particularly the Nigerian government adopted WHO-recommended containment measures to limit the spread of the virus and the associated catastrophe. These measures included lockdowns, shutdowns, social distancing, and personal hygiene among other preventive procedures. Even though the pandemic was relatively less endemic in Africa, as per official statistics, African states swiftly implemented the WHO containment measures, which impacted negatively on the livelihood of the average household, who depends on daily incomes for survival. The worsening living condition caused by the containment measures expectedly deepened resentment against governments in Africa with already poor records of public service delivery, accountability, transparency, and human rights. Nigeria was one of the African countries that experienced citizens' backlash and violent outrage against government policy choices during the COVID-19. Under the guise fighting police brutality, youths staged mass anti-government protests that transformed into large scale violence, particularly in the southern parts of the country otherwise known as the “EndSARS Protests.” The protests were conceived against police brutality in the enforcement of COVID-19 measures. This article examined the outbreak of EndSARS protests as a transformation of the deepening of political trust deficits in age of COVID-19. It adopted qualitative approach using documentary evidence such as newspaper reports and official documents as instruments of data collection. The Institutional Performance Theory guided the article. The theory assumes that the actual performance of government determines citizens' level of trust and confidence in public institutions. The article found that perennial government inefficiency, limited accountability and transparency as well as poor human rights records of the government and its agencies, particularly the police exacerbated an already existing political trust deficits amongst the people in Nigeria. This was manifested in the outburst of a large-scale violent outrage by the youths as protest to the government containment measures and widespread dysfunctional governmental institutions and particularly police brutality. The article concluded that building trust is particularly important for governments, as this can be achieved through output sense, the provision of public goods, or social support.
“Eco-caring together” pro-ecological group-based community interventions and mental wellbeing: a systematic scoping review
Authors: Baker Kane , Chioran Bianca , Marks Elizabeth
Published: April 2024

Background

Poor mental wellbeing is a challenge for societies across the world, as is the increasing threat of climate change, and emerging evidence suggests these challenges are interrelated. Green and social prescribing of non-clinical interventions hold promise as a cost-effective and widely accessible way to improve wellbeing, and interest is growing in whether pro-ecological communal activities have mutual benefits for both people and the planet.

Objectives

Communal pro-ecological activities are growing in popularity, and research is gathering pace into whether participation influences mental wellbeing. The present systematic review scopes the existing evidence base to explore what is being done, what is being found, and what additional research is required.

Methods

Electronic databases (PsychNET, PubMed, Scopus, and Web of Science) were searched for studies that involved groups of people undertaking pro-ecological activities, where components of mental wellbeing were assessed. Eligibility criteria were purposely broad, including all study designs and participants across the lifespan.

Results

Thirty-seven eligible studies were identified. Nearly half of the studies used mixed-method designs, and most studies used surveys or interviews to evaluate outcomes. Most pro-ecological activities involved planting vegetation, and habitat creation, maintenance, or restoration. Methodological quality varied considerably. Among the perceived therapeutic mechanisms reported, the social elements of the interventions were prominent.

Discussion

Coherent synthesis of the current evidence base is challenging given the heterogeneous range of methods, samples, and interventions within the studies. However, the results here demonstrate promise that with future research and better methodological rigor, pro-ecological group-based interventions hold the potential to improve mental wellbeing and influence sustainable behavior.

Systematic review registration

https://osf.io/vmpr6/.
When failure is not an option: a police firearms training concept for improving decision-making in shoot/don’t shoot scenarios
Authors: Olma Joshua , Sutter Christine , Sülzenbrück Sandra
Published: April 2024

Sometimes, policing requires a quick and correct assessment of potentially hazardous situations. The training of tactical gaze control and visual attention, and its positive impact on efficient shoot/don’t shoot decisions in police cadets’ use of firearms has recently been demonstrated. On this basis, we designed an individual videobased police firearms training that was grounded on the Four-Component Instructional Design Model (4C/ID). We shifted toward an individual blended learning approach where we applied an intervention training focused on situational awareness, tactical gaze control, and visual attention. In a preregistered lab experiment, N = 45 senior police officers were randomly allocated to the intervention training or an active control training that resembled a traditional police firearms training. Both groups watched a self-produced educational video before proceeding to the practical training in our indoor firing range. In a pre- and post-test, they engaged in realistic shoot/don’t shoot video scenarios. Both groups did very well regarding decision-making, the optimal muzzle position, and the tactical conduct to keep both eyes open before shooting. Although both groups performed on a comparable level in the pre-test’s shoot scenarios, the intervention group significantly improved their response times and time until the first hit. Overall, we were able to provide an adapted, didactically based police firearms training that supplements current standards. We demonstrated that experts are still susceptible to innovative training concepts and therefore substantiate the recommendation to devote more attention to approaches that emphasize the importance of situational awareness, tactical gaze control, and visual attention in police firearms training.
Is passion contagious in coach-athlete dyads? A dyadic exploration of the association between passion, affective and need-based experiences in individual sports
Authors: Fonteyn Marieke , Haerens Leen , Vansteenkiste Maarten , Loeys Tom
Published: April 2024

The Dualistic Model of Passion distinguishes between harmonious and obsessive passion, which are associated with athletes’ and coaches’ adjustments. Whereas prior research sampled either athletes or coaches, the present study used a dyadic approach to explore the bidirectional influence of passion on affective experiences in coaches and athletes. Using a cross-sectional dyadic design, 198 coach-athlete dyads involved in an individual sport at different competition levels, reported on their passion, need-based, and affective experiences. Both actor effects (i.e., intrapersonal dynamics within athletes or coaches) and partner effects (i.e., interpersonal dynamics from coach to athlete and vice versa) were examined. Furthermore, dyadic mediation models were used to investigate the potential mediating role of need-based experiences in the association between passion and affective experiences. Results unveiled compelling evidence for actor effects, indicating that one’s own harmonious passion was positively related to one’s own more adaptive outcomes and negatively to one’s own more maladaptive outcomes, whereas obsessive passion was positively related to maladaptive outcomes. Further, very limited evidence for partner effects, in which coaches’ passion affected athletes’ outcomes or vice versa, was found. The dyadic mediation models underscored the role of need-based experiences in mediating the association between passion and affective experiences, but only at the intrapersonal level. As such, one’s own passion experiences were related to one’s own need-based experiences, which in turn were related to one’s own affective experiences. The study provided no evidence for interpersonal mediation effects.
Expanding the scope of “trans-humanism”: situating within the framework of life and death education – the importance of a “trans-mystical mindset”
Authors: Phan Huy P. , Ngu Bing Hiong , Hsu Chao-Sheng , Chen Si-Chi , Wu Lijuing
Published: April 2024

Life and death education, as noted from the literatures, has been studied and researched extensively in China, Malaysia, and Taiwan. Our own research undertakings over the past several years, situated in different sociocultural settings have delved into aspects of life and death that could help advance theoretical understanding of the subject matters (e.g., does the meaning of “effective life functioning” connote differing interpretations for different cultural groups?). Situating within the framework of life and death education, we expand the study of trans-humanism by introducing an extended prefix or nomenclature known as “trans-mystical”. Specifically, our philosophized concept of trans-mysticism considers a related concept, which we term as a “trans-mystical mindset”. A trans-mystical mindset, differing from an ordinary mindset, from our philosophical rationalization, is defined as “a person’s higher-order state of consciousness, espousing her perception, judgment, belief, and attempted interpretation of life and death phenomena that are mystifying and fall outside the ordinary boundaries of human psyche.” Our focus of inquiry, as reported in the present article, seeks to advance our proposition: that a trans-mystical mindset, unlike an ordinary mindset, may help a person to rationalize, appreciate, and understand metaphysical contexts, mystical experiences, and the like. This focus, interestingly, serves to highlight an important discourse - namely, that there is a dichotomy in theoretical lenses (i.e., objective reality vs. individual subjectivity) that a person may use to rationalize the significance or non-significance of universal contexts, events, phenomena, etc. (e.g., a person’s experience of “premonition”). As such, then, there is an important question that we seek to consider: whether philosophization, or the use of philosophical psychology, would yield perceived “scientific evidence” to support or to reject the study of metaphysicism, mysticism, and the like? For example, does our philosophization of an “equivalency” between a person’s trans-mystical mindset and her experience of self-transcendence help to normalize and/or to scientize the subject matters of metaphysicism, mysticism, etc.?
Effects of an online mindfulness-based program for parents of children with attention deficit/hyperactivity disorder: a pilot, mixed methods study
Authors: Lo Herman Hay Ming , Lam Jason , Zhang Zoe Ji-wen , Cheung Marsena , Chan Stanley Kam Chung , Wong Elisabeth Wai Yin , Bögels Susan M. , Chui Wing Hong
Published: April 2024

Objectives

Online mindfulness-based program (MBP) for parents and families especially in clinical population is limited. Engagement and significant dropout are major issues in MBP implementation. This pilot study examined the effects of an online mindfulness-based program (MBP) on parents of children with Attention Deficit/Hyperactivity Disorder (ADHD).

Methods

A mixed methods study was applied to evaluate the effects of the MBP. A total of 43 parents were recruited and were randomly assigned into intervention group and waitlist control group. The online MBP lasted for 28 days, including 20 psychoeducation videos, homework audio guidance, and four instructor-led online group meetings. Purposive sampling was used to recruit parents who completed the program to share their experiences and suggestions for improving the program in semi-structured online interviews.

Results

Quantitative data showed that participants from the online MBP reported a medium to large effect on the reduction of child ADHD symptoms. In semi-structured interviews, participants reported positive experiences in their help seeking intention, and personal changes, such as emotion regulation and quality attention to their children. Participants further made suggestions for improvement.

Conclusions

The effect of online MBP is promising, and the program should be conducted. A large scale randomized controlled trial should be conducted to investigate the effects of MBP in clinical populations.

Clinical trial registration

ClinicalTrials.gov NCT05480423.
Examining the effectiveness of a training program on improving knowledge, functional skills, and attitude in natural disaster volunteers
Authors: Amini Fereshteh , Hidarnia Alireza , Ghofranipour Fazlollah , Motlagh Mohammad Esmaiel
Published: April 2024

Introduction

Disaster relief volunteers must have certain psychological and cognitive characteristics. Therefore, the present study aimed to investigate the effectiveness of the training program on improving knowledge, functional skills, and attitude among disaster volunteers.

Methods

A quasi-experimental study was conducted in 2023 in Iran, including an intervention and control group and follow-ups. Ninety health volunteers were randomly selected and divided into two groups of 45. The experimental group received the training program for an hour a week for three months. The control group received no intervention. The participants of both groups completed the disaster preparedness questionnaire at the pre-test, post-test, and one and three months after the intervention. Data was analyzed using SPSS “version 26” software in the methods section.

Results

The intervention effect were significant in increasing the volunteers’ functional skills (F = 3.75), knowledge (F = 166.50), and attitude (F = 1.74), all in (p = 0.001). According to the results, this effect was stable over time for functional skills (F = 1.83) and knowledge (F = 18.04) all in (p < 0.05).

Conclusion

Training programs can help improve skills, attitudes and knowledge in natural disaster volunteers. Researchers interested in the field of natural disaster relief, particularly health researchers, could consider further examining the aforementioned topics in their studies.
Analysis of the situations and influencing factors of public anxiety in China: based on Baidu index data
Authors: Xie Tiantian , Huang Zetao , Tan Yue , Tan Tao
Published: April 2024

Background

Anxiety disorders have emerged as one of the most prevalent mental health problems and health concerns. However, previous research has paid limited attention to measuring public anxiety from a broader perspective. Furthermore, while we know many factors that influence anxiety disorders, we still have an incomplete understanding of how these factors affect public anxiety. We aimed to quantify public anxiety from the perspective of Internet searches, and to analyze its spatiotemporal changing characteristics and influencing factors.

Methods

This study collected Baidu Index from 2014 to 2022 in 31 provinces in mainland China to measure the degree of public anxiety based on the Baidu Index from 2014 to 2022. The spatial autocorrelation analysis method was used to study the changing trends and spatial distribution characteristics of public anxiety. The influencing factors of public anxiety were studied using spatial statistical modeling methods.

Results

Empirical analysis shows that the level of public anxiety in my country has continued to rise in recent years, with significant spatial clustering characteristics, especially in the eastern and central-southern regions. In addition, we constructed ordinary least squares (OLS) and geographically weighted regression (GWR) spatial statistical models to examine the relationship between social, economic, and environmental factors and public anxiety levels. We found that the GWR model that considers spatial correlation and dependence is significantly better than the OLS model in terms of fitting accuracy. Factors such as the number of college graduates, Internet traffic, and urbanization rate are significantly positively correlated with the level of public anxiety.

Conclusion

Our research results draw attention to public anxiety among policymakers, highlighting the necessity for a more extensive examination of anxiety issues, especially among university graduates, by the public and relevant authorities.
Prehospital use of point-of-care tests by community health workers: a scoping review
Authors: Ebbs Daniel , Taricia Max , Funaro Melissa C. , O’Daniel Maggie , Cappello Michael
Published: April 2024

Introduction

Point-of-Care Tests (POCTs) are utilized daily in resource abundant regions, however, are limited in the global south, particularly in the prehospital setting. Few studies exist on the use of non-malarial POCTs by Community Health Workers (CHWs). The purpose of this scoping review is to delineate the current diversity in and breadth of POCTs evaluated in the prehospital setting.

Methods

A medical subject heading (MeSH) analysis of known key articles was done by an experienced medical librarian and scoping searches were performed in each database to capture “point of care testing” and “community health workers.” This review was guided by the PRISMA Extension for scoping reviews.

Results

2735 publications were returned, 185 were nominated for full-text review, and 110 studies were confirmed to meet study criteria. Majority focused on malaria (74/110; 67%) or HIV (25/110; 23%); 9/110 (8%) described other tests administered. Results from this review demonstrate a broad geographic range with significant heterogeneity in terminology for local CHWs.

Conclusion

The use of new POCTs is on the rise and may improve early risk stratification in limited resource settings. Current evidence from decades of malaria POCTs can guide future implementation strategies.
Body mass composition analysis as a predictor of overweight and obesity in children and adolescents
Authors: Aniśko Bartosz , Siatkowski Idzi , Wójcik Małgorzata
Published: April 2024

Introduction

Body mass composition is directly related to health and its disorders are correlated with diseases such as obesity, diabetes, osteoporosis and sarcopenia. The purpose of this study was to analyze body mass composition among traditional elementary school students and ballet school students.

Methods

A total of 340 students participated in the study, 95 of whom attended ballet school and 245 elementary school students. A Tanita BC-418 MA analyzer was used to analyze body mass composition. Such body composition indices as BMI (Body Mass Index), muscle mass, fat mass, lean body mass and water content were evaluated.

Results

The results show statistical significance for BMI between high school ballet students and elementary school ballet students, as well between high school ballet students and elementary school students. Comparisons in relation to gender and schools BMI, statistical significance was obtained for: BHSw (ballet high school women) and EBSw (elementary ballet school women), BHSw and ESw (elementary school women), BHSm (ballet high school men) and EBSm (elementary ballet school men), and between BHSm and ESw. Comparing muscle mass index (kg) between ballet high school and elementary school, between ballet high school and elementary school, and between ballet high school and elementary school - statistical significance was obtained for all comparisons. Analyzing in pairwise comparisons by gender and school achieved a statistically significant difference for: BHSw and EBSw, BHSm and EBSw, EBSw and ESm. Comparing the fat mass index (kg), no significant differences were observed between the analyzed schools and the school and gender of the children studied. The value of the lean body mass index differed significantly between groups by school and gender. Comparing the water content index, statistically significant differences were obtained for school and gender.

Discussion

The body mass composition of ballet school students differs from that of standard school students.
The impact of widowhood on the mental health of older adults and the buffering effect of social capital
Authors: Zheng Jichao , Yan Lei
Published: April 2024

Background

Widowhood is one of the most serious issues affecting the mental health of older persons. China currently has tens of millions of widowed older adult, which is a huge group. It is of great significance to study the impacts of widowhood on their mental health and put forward some measures for improvement.

Method

We used China Family Panel Studies (CFPS) data in 2020, which included 4,184 older adults. Linear regression is used to examine the relationship among widowhood, mental health, and social capital.

Results

Both short-term and medium- and long-term widowhood lead to a significant increase in depression, which seriously affects the mental health of older people. At the same time, community-level and family-level social capital have significant buffering effects on the loss of mental health caused by widowhood, but this effect is heterogeneous, with different types of social capital playing different roles among different gender groups.

Conclusion

The provision of care support by children and good neighborhood relationships can help mitigate the psychological impact of widowhood, and these are areas where social policy can make a difference.