bluuebunny/crossref_metadata_2025 huggingface dataset:
Classification of industrial development concepts at the present stage of modification of the regional economy
Authors: Mironova Elena A. , Chebykina Marina V. , Shatalova Tatyana N.
Published: July 2024

The article analyzes modern problems of modifying industrial development at the regional level; modern fundamental concepts of industrial development are explored; the importance of the knowledge economy and the concept of sustainable development for industry is substantiated. It is proved that in modern economic realities the concepts of industrial development are especially important at the micro level. A classification of industrial development concepts at the present stage of functioning of the regional economy is presented, taking into account their contribution. An integrated approach is substantiated when making decisions on modifying the development of the regional economy, which requires taking into account various factors at all levels of management: from the state, where economic, foreign economic, innovation and industrial policies are formed, to the regional, local and corporate levels, where this policy is actually implemented. The key in this context is not only the fact of government intervention itself, but also the methods of this intervention, as well as the use of various tools to achieve structural change. The importance of flexibility in regional policy is emphasized, especially its horizontal orientation, where the emphasis is on how the state enters the process and what tools it uses to achieve its goals. The definition of modification of industrial development is being revised, considering it as a systematic change in the structures, forms and methods of functioning of objects and subjects of the industrial sector, highlighting the main directions of modification at the regional level.
A tanulói beszéd fatikus funkciójú nyelvi elemei az osztálytermi diskurzusban
Authors: Asztalos Anikó
Published: July 2024

A tanulmány témája a fatikus funkciójú nyelvi elemek vizsgálata a tanulói beszédben. A fatikus funkció a nyelv elsődleges funkciójaként az osztálytermi diskurzusban támogatja a tanár és a diákok közötti kapcsolat létrehozását, fenntartását és lezárását, tükrözi az interperszonális kapcsolat jellegét. A bemutatott kutatás célja a tanulók beszédfordulóiban megjelenő verbális fatikus funkciójú elemek típusainak a megfigyelése. A tanulmány 12 magyar nyelvi tanóra videós anyagának annotálása és szegmentálása alapján mutatja be az osztálytermi diskurzus jellemzőit, emellett differenciálja a fatikus funkciójú nyelvi elemek fajtáit a tanulók beszédében. A nyelvi példák alátámasztják, hogy diákok csak korlátozottan veszik fel a kapcsolatot a tanárral és egymással is, valamint a fatikus funkciójú nyelvi elemek megjelenésében több olyan jellemző van, amely a tanulói beszéd sajátosságaihoz sorolható. Az osztálytermi diskurzus működésének feltárásával a kezdő és a gyakorló pedagógusok is jobban felismerhetik azt, hogy milyen hatást gyakorolnak a saját beszédükkel a tanulók beszédére.
Self-discharge dynamics and accelerated test approach for state-of-charge forecast for lithium cells BR2325
Authors: Mit'kin V. N. ,   Institute of Inorganic Chemistry of A. V. Nikolaev of the Siberian Branch of RAS, Galitskii A. A. , Vovchuk V. E. ,   Institute of Inorganic Chemistry of A. V. Nikolaev of the Siberian Branch of RAS,   Institute of Inorganic Chemistry of A. V. Nikolaev of the Siberian Branch of RAS
Published: July 2024

There were investigated the self-discharge dynamics in two homogeneous groups («A» and «B») of the coin lithium cells ВR2325 on the basis of superstoichiometric fluorocarbon CF1.20, selected from the uniform experimental batch of 10000 pieces. The reason of two different groups («A» and «B») appearance through 3–6 months of storage is connected with the origin of hydrogen fluoride in cathodes of group «A» cells, which will be derivated at auto catalytic hydrolysis of C-F-bonds by a moisture tracers (0.1–0.5%). It was established, that a self-discharge rate in the group «A» cells ten times exceeds the same in the group «B», and the intensity of a self-discharge processes is connected to microcorrosion migration reactions of metals from cathodic current-holder to the lithium anode. The self-discharge rate of the selected «B» group was studied both during real time storage at room temperature and various temperature exposure on cells during different time periods (T°C, t). It was shown that for this lithium cells group after 3 year storage an activation energies (Ea) both for self-discharge and microchemical processes of metal migration (Fe, Ni, Cr) from current pick-off to anode are almost similar and equal to 14–16 kcal/mol. The self-discharge processes for BR2325 at 25–80°C can be described using linear equation Q (T°C, t) = Q0 + W0t, the reaction rate can be approximated by the first order per time and by the zero order per migrating metal impurities. Based on the study of microcorrosion processes dynamics and an integrated computer-aided diagnostics of the regression multiparameter analysis the general approach to development of procedures of accelerated tests of these lithium cells was achieved. This approach is consisted of the combination of self-discharge rate study with simultaneous corrosion processes analysis.
Lithium rechargeable work in the systems with polymer electrolytes based on C-PVC and PVDE
Authors: Kolomoets O. V. ,   Ukrainian State Chemical and Technological University, Maksyuta I. M. , Chervakov O. V. , Shembel' E. M. ,   Ukrainian State Chemical and Technological University,   Ukrainian State Chemical and Technological University,   Enerize. Corp, Coral Springs, FL, USA
Published: July 2024

Electrochemical behavior of Li in the systems with PE based on polymers of chlorinated polyvinylchloride and polyvinylidene fluoride were investigated by the method of cyclic voltammetry and galvanostatic cycling. Potentiodynamic investigations have shown that on lithium electrode even in the systems with polymer electrolyte the high current densities up to 5 mA/cm2 are realized. Influence of polymer electrolyte composition on the properties of the interface Li/electrolyte and rechargeable work of lithium electrode has been shown. The developed PE have been tested in the pilot prototypes of power sources of the system Li-LiMn2O4 и Li-MnO2.
Evaluation of Ergonomic Risks Factors in a Dental Center Located in the Historical Center of the City of Riobamba
Authors: Calderón-Vallejo J , A Noguera-Cundar A , Castro-Cepeda L , Moreno- Barriga M
Published: July 2024

The present investigation focuses on ergonomic study of different activities, belonging to the Mipymes group, carried out in a dental office in the city of Riobamba. Analysis carried out within the research project ”Strengthen the preventive management of occupational health and safety within the MSMEs of the Riobamba canton.” The tasks performed by dental professionals require static postures, high workloads, and ergonomics. Therefore, the physical and postural activities carried out by dentists in their different specialties are evaluated, which leads to an ergonomic study of the dental workplace, using the REBA methodology, which evaluates the worker’s posture, identifying incorrect body positions. The results obtained show, in effect, that the postures of those who work in the dental area are inadequate, causing short and long-term health conditions. Finally, a set of corrections and a preventive plan are proposed to reduce ergonomic risks.
Keywords: safety, ergonomics, dentistry, REBA, MIPYMES.
Resumen
En la presente investigación se muestra un estudio ergonómico de las diferentes actividades que se realizan en un consultorio odontológico, perteneciente al grupo de las Mipymes de la ciudad de Riobamba. Análisis efectuado dentro del proyecto de investigación “Fortalecer la gestión preventiva de la seguridad y salud ocupacional dentro de las MIPYMES del cantón Riobamba”. Las tareas realizadas por los profesionales dentales requieren posturas estáticas, carga laboral y ergonómica alta. Por tanto, se evalúan las actividades físicas y posturales que realizan los odontólogos en sus diferentes especialidades, que conlleva a un estudio ergonómico del puesto de trabajo odontológico, utilizando la metodología REBA, misma que evalúa la postura del trabajador, identificando posiciones corporales incorrectas. Los resultados obtenidos muestran en efecto, que las posturas de quienes laboran en el área dental son inadecuadas provocando afecciones a corto y largo plazo de su salud, finalmente se propone un conjunto de correcciones y un plan preventivo para disminuir los riesgos ergonómicos.
Palabras Clave: seguridad, ergonomía, odontología, REBA, MIPYMES.
Development of a Method for Diagnosing Faults in Hydraulic Systems Using Artificial Neural Networks with Deep Learning
Authors: Mera Hugo , García Félix , Calderón Edisson
Published: July 2024

The application of artificial intelligence is a recent improvement in the industry, allowing preventive maintenance to be applied as a reliability method for detecting failures in hydraulic systems. This is achieved by using artificial neural networks (ANN) as classifiers to make automatic binary and categorical decisions. Since these systems have multiple conditions and sub-conditions that can be complex for normal analysis, the UCI repository database is relied upon to construct an intelligent algorithm of artificial neural networks with deep learning. This has proven to be a highly effective way of predicting failures, with an overall accuracy rate of 97% when applying the intelligent model to the system. As a result, it can be concluded that deep learning is much more efficient than classical machine learning.
Keywords: artificial intelligence, predictive maintenance, artificial neural networks, deep learning.
Resumen
La aplicación de la inteligencia artificial es la nueva mejora en la industria, permitiendo que el mantenimiento preventivo se aplique como método de confiabilidad para la detección de fallos en sistemas hidráulicos aplicando Redes neuronales artificiales (ANN), utilizándoles como clasificadores para obtener una toma de decisiones automáticas de manera binaria y categórica, ya que dichos sistemas poseen varias condiciones y subcondiciones que se vuelven complejas para un análisis normal, apoyándose en la base de datos del repositorio de la UCI, siendo analizados para la construcción de un algoritmo inteligente de redes neuronales artificiales con Deep Learning (aprendizaje profundo), demostrando así un alto desenvolvimiento en la predicción de fallos, obteniéndose un 97% de exactitud (accuracy) de manera general en la aplicación del modelo inteligente al sistema. Se concluye que la aplicación del aprendizaje profundo es mucho más eficiente comparado con el aprendizaje automático clásico.
Palabras Clave: Inteligencia artificial, mantenimiento predictivo, Redes Neuronales Artificiales, Aprendizaje profundo.
Bridging the Wealth Gap
Authors: Mehta, MD Roma
Published: July 2024

In this opinion piece supported by empirical studies, the author will argue the significance of educating women on financial literacy, asserting its pivotal role in enhancing outcomes for both physicians and the healthcare systems within which they operate. It is well-documented that financial strain correlates with burnout among physicians and trainees, resulting in substantial losses in productivity amounting to millions of dollars. It is postulated that fostering financial empowerment in women may serve as a strategic intervention to mitigate stressors and consequently ameliorate overall well-being within the medical institutions.
On Prerequisites for the Origination of Legal Self-Organization in Sports
Authors: Asadullin Murad R. ,   Associate Professor of the Department of Political Science and Public Relations of the Ufa University of Science and Technology
Published: July 2024

The article is devoted to the analysis of the causes of legal self-organization in sports. The development of sports has set objective tasks for the civil society to organize it. As a result of this significant amount of work, the Olympic Movement was created from the structure of the International Olympic Committee (hereinafter — the IOC), the Olympic Charter was adopted, this movement and the principles of its activities are recognized by the overwhelming majority of countries around the world. Traditional legal regulation in the form of creating models of behavior based on the norms of law is also possible in relation to sports organizations, but it is limited in terms of defining organizational and legal forms, registration procedures and practically does not affect the results of their activities as autonomous civil communities. Attention is drawn to the fact that the relations that develop in sports are heterogeneous, have not the same legal nature, are regulated in different ways, which allows them to be conditionally divided into those that are in the sphere of decisive influence of the methodology of private law and those that are mostly adjacent to public law regulation (you can say “directive”). Therefore, it is important to take into account the existence of an external impact in the form of a) acts of state regulation of relations in sports (public law aspect) and b) internal decisions of the communities of athletes (private law aspect). These areas of regulation are manifested mainly as certain approaches to regulation, characteristic of acquiring relevant rights and (or) defending relevant “interests”.
Self-Regulation of Activities as an Integral Condition of Existence of a Corporate Legal Structure
Authors: Barkov Aleksey V. ,   Professor of the Department of Civil Law of the Prince Alexander Nevsky Military University of the Ministry of Defense, Petrash Igor P. ,   Senior Lecturer of the Department of Civil Law of the Prince Alexander Nevsky Military University of the Ministry of Defense
Published: July 2024

The purpose of the article is to show the connection between “values” and legal corporate instruments, substantiating the thesis on the example of B corporations (private military companies of the 21-st century) that self-regulation is an integral condition and context for the existence of any legal corporate instrument due to the subordination of “law” to “speech” — this fact has been remained unnoticed for a long time only due to errors in the application of scientific research methods.
On the Regulation and Main Tendencies of Filling Vacancies at the State Civil Service
Authors: Naumova Yulia V. ,   Head of the Department of State Service, Mobilization Training and Human Resources of the Directorate of General Affairs
Published: July 2024

The article is devoted to the issue of formation of the personnel composition of federal executive bodies in the process of filling positions of state civil service on a competitive basis and without competition, comparative assessment of the level of personnel turnover for 2019-2021 in the central apparatuses of federal executive bodies and identification of trends in filling vacant positions, determining the role of assessing a candidate's professional level in the process of forming quality personnel of a federal body.
Curing Kinetic Analysis and Isothermal Prediction of DBTL Catalyzed Polyurethane Reaction by Differential Scanning Calorimetry
Authors: Sevim Ünlütürk Seçil , Güdümcüoğlu Necati
Published: July 2024

Kinetic analysis is generally carried out to clarify the reaction mechanism with kinetic parameters and to predict the kinetic properties of materials under different reaction parameters. The kinetics of the polyurethane polymerisation reaction between acrylic polyol and isocyanate was investigated by Differential Scanning Calorimetry (DSC) in terms of catalyst amounts and sampling times. Single and multiple heating analyses were used to obtain DSC curves for each sample. The simple kinetic model and Multilinear Regression Fit (MRF) were used to calculate the kinetic parameters and simulate the isotherm prediction curves. The kinetic calculations showed that the glass transition temperatures (up to 44 oC) and activation energy (Ea) values increased with the degree of conversion for all cases. The reduction in the rate constant for partially cured samples was greater than the initial sampling time of the same sample. This observation indicates that the diffusion-controlled reaction dominates and Ea increases due to the highly cross-linked and dense medium in partially cured samples. Isothermal prediction curves provide an understanding of different curing conditions at different reaction temperatures and times. Prediction curves show slower conversion even for final samples, confirming that final samples may remain uncured. Applying the results of this study, especially for real-world applications, where fully cured samples are required, additional annealing procedures can be easily established.
APLICAÇÃO DA SALA DE AULA INVERTIDA NA FORMAÇÃO ON-LINE DE EDUCADORES
Authors: Gruber Crislaine , Mendonça Igor Thiago Marques
Published: July 2024

Este artigo apresenta a experiência de aplicação da Sala de Aula Invertida totalmente on-line na formação de professores. A atividade foi organizada em um momento prévio de estudos, assíncrono, e um momento síncrono, no qual os participantes realizaram uma atividade prática em grupos. Para o momento síncrono, foi realizada uma Webprática, estratégia metodológica criada no âmbito do projeto pedagógico da Pós-Graduação em Tecnologias para Educação Profissional. Para elaboração do artigo, coletou-se os materiais usados no planejamento e produção da atividade e analisou-se os dados de avaliação de 138 dos 235 participantes em 4 aplicações distintas, procedendo-se, por fim, com uma discussão à luz da literatura. Os resultados mostraram, com ampla margem, uma avaliação positiva dos participantes. A maioria deles concorda que a atividade contribuiu para o seu aprendizado e sua formação profissional, que a estratégia didática utilizada foi envolvente, que houve equilíbrio entre teoria e prática e que foi fácil entender a dinâmica utilizada. Por fim, observou-se que, diferente do que é relatado na literatura sobre Sala de Aula Invertida, houve boa participação na etapa assíncrona da metodologia.
AS REDES SOCIAIS COMO FERRAMENTA PEDAGÓGICA: uma revisão sistemática da literatura sobre suas potencialidades
Authors: Lisbôa Eliana Santana , Silva Lilia Kelli da
Published: July 2024

As redes sociais estão se tornando uma ferramenta cada vez mais importante na vida cotidiana. Mais do que uma distração, quando usadas adequadamente, elas podem ser úteis para auxiliar no trabalho em sala de aula. Este estudo verificou a eficácia do uso das redes sociais (Instagram, Facebook, WhatsApp e Telegram) na educação e suas potencialidades como ferramenta pedagógica na construção do conhecimento. Foi realizada uma Revisão Sistemática de Literatura com os seguintes critérios de inclusão: i) tipo de estudo: empírico e/ou revisão de literatura; ii) ano de publicação: 2017 a 2021; iii) idioma: publicações em inglês ou português. As buscas resultaram em 129 publicações, das quais 44 foram analisadas. Identificou-se que as redes mais utilizadas no contexto educativo são Instagram e WhatsApp. Elas são mais usadas no ensino superior, seguidas pelo ensino médio. Professores utilizam essas redes para compartilhar experiências, avaliações e materiais de aprendizagem. Notou-se que as redes sociais são usadas como recurso para metodologias ativas, como o estudo de caso. Conclui-se que as redes sociais têm grande potencial educativo, sendo espaços de comunicação e interação que transcendem tempo e espaço.
JOGOS DIGITAIS COMO RECURSO DIDÁTICO: uma perspectiva promissora para alfabetização de alunos com deficiência intelectual
Authors: Lima Sildenice Melo de , Menezes Aline Furtado , Serra Ilka Marcia Ribeiro de Sousa
Published: July 2024

O uso de recursos lúdicos, interativos e inovadores despertam nas crianças o interesse pela aprendizagem, considerando que diariamente fazem uso da tecnologia, o que vem justificar a relevância desta pesquisa para os sujeitos aqui relacionados. Trata-se de um estudo descritivo sobre jogos digitais e alfabetização de estudantes com Deficiência Intelectual-DI, construído sob preceitos históricos e sociais, com base em uma necessidade atual que perpassa a longa história da educação no Brasil. Quanto à natureza da pesquisa, foi desenvolvida utilizando método qualitativo com estudo bibliográfico. Os instrumentos adotados na realização da pesquisa bibliográfica foram: livros, artigos científicos, teses, dissertações, revistas, e outras fontes escritas já publicadas. Partindo da problematização de como os jogos digitais podem contribuir no processo de alfabetização e apropriação do sistema de escrita alfabética por crianças com deficiência intelectual, buscou-se analisar a contribuição dos jogos digitais no processo de alfabetização de crianças com DI. Apresentar a concepção de deficiência intelectual e discutir os benefícios dos jogos digitais nas salas de aula como recurso metodológico no ciclo de alfabetização. Pode-se concluir que os jogos digitais educacionais permitem desenvolver habilidades cognitivas, potencializar a aprendizagem, oferecendo oportunidades para experimentar e socializar novas identidades, com efeito motivacional, permite estimular a coordenação motora.
Analisis Pemanfaatan Aplikasi iPusnas sebagai Sumber Belajar oleh Mahasiswa IlmuPerpustakaan dan Informasi Islam IAIN Curup
Authors: Rizkyantha Okky
Published: July 2024

This study aims to determine the use of the iPusnas application as a learning resource by IAIN Curup Islamic Library and Information Science students and to determine the inhibiting factors in the use of the iPusnas Application as a Learning Resource by IAIN Curup Islamic Library and Information Science Students. This study used a type of descriptive qualitative research using interview, observation, and documentationtechniques. The informants in this study are two students of Islamic Library and Information Science class of 2020, two students of IslamicLibrary and Information Science class of 2021, and two students of Islamic Library and Information Science class of 2023. From the results of the research, researchers can find that the use of the iPusnas application as a learning resource by students of Islamic Library and Information Science when viewed from the aspect of usefulness and ease in learning activities is still not optimal. Because references to books, journals, and articles are still limited and there is still a lack of user understanding in using existing features to find learning references. So users can't find the books, journals, and articles they want. But even so, users feel that it has been helped by utilizing the iPusnas application, users can find other books as their learning references. The inhibiting factors in the use of the IPUSNAS application as a learning resource are divided into internal factors and external factors. The internal factor is that this application still has many errors or system errors. The collection available on the iPusnas application is still small. And the external factor, namely the user's regular internet connection that is unstable or slow, is an inhibiting factor in the use of the iPurnas application.
A Review of Extraterrestrial Organic Carbon and its Potential Impact on Life on Earth
Authors: Yarkasih Firza Riyadhini , Nurita Tutut , Al-Zahzamri Nariyah , Pratiwi Riska Ayu , Khasanah Nur
Published: July 2024

The universe is a space containing large amounts of both organic and inorganic carbon that has the potential to encourage heterotrophs on habitable planets. Meteorites are materials that can transport carbon from outer space to the planet's surface. Meteorites bombarded the Earth's surface during the early days of evolution and proliferation of life, potentially providing a source of abiotic organic carbon to support early life. This study aims to analyze research methods used in detecting the use of space organic carbon, analyze research results related to the role of space organic carbon, and provide further understanding to the researchers associated with organic carbon from space and its potential in human life on Earth. This study uses a systematic review method using 15 sources of information from national and international news and journal articles related to space organic carbon and its potential. This study showed that extraterrestrial organic carbon produces a source of carbon that is beneficial for microorganisms to integrate into their proteins. Combining inverse stable isotope labeling and infrared spectroscopy shows that organic carbon from Aguas Zarcas carbon chondrite can be harnessed for cell growth. Previous discoveries have also shown that aerobic microbial communities have potential in human space settlement plans to access and research carbonaceous asteroid material.
A new approach toward the quantum foundation and some consequences
Authors: Helland Inge S.
Published: July 2024

A general theory based on six postulates is introduced. The basic notions are theoretical variables that are associated with an observer or with a group of communicating observers. These variables may be accessible or inaccessible. From these postulates, the ordinary formalism of quantum theory is derived. The mathematical derivations are not given in this article, but I refer to the recent articles. Three possible applications of the general theory can be given as follows: (1) the variables may be decision variables connected to the decisions of a person or a group of persons, (2) the variables may be statistical parameters or future data, and (3) most importantly, the variables are physical variables in some context. The last application gives a completely new foundation of quantum mechanics, a foundation which in my opinion is much easier to understand than ordinary formalism. So-called paradoxes like that of Schrödinger’s cat can be clarified under the theory. Explanations of the outcomes of David Bohm’s version of the EPR (Einstein–Podolsky–Rosen) experiment and the Bell experiment are provided. Finally, references to links toward relativity theory and quantum field theory are given. The concluding remarks point to further possible developments.
Architecture as a Symbol of Social-Economic Relationship at Al Munawar Village in Palembang
Authors: Adiyanto Johannes , Prima Listen , Romdhoni Muhammad Fajri
Published: July 2024

Palembang is a city with a long history and one of the oldest cities in Indonesia. One of the driving aspects for the formation of the city is its reputation as the area for main trade in Southern Sumatra. The trade also encouraged the development of immigrant communities which later became their inhabited colonies such as the Al-Munawar Village inhabited by immigrants from Yemeni Arabs. The primary goal of this research is to demonstrate the impact of trade interactions on architectural expression. This demonstrates that architectural form is impacted by a variety of factors, namely commercial interactions. Therefore, this research was conducted to determine the correlation between the history of a community and its architectural elements ranging from regional spatial planning to decorative elements. This involved using the historical research approach with architectural semiotic analysis techniques. The results showed that the spatial layout of Al-Munawar Village has a typology similar to those in settlers' villages, for both fellow Yemeni Arabs in Sungai Lumpur Village and Chinese migrants in Kapitan Village. It was also discovered that the buildings in Al- Munawar Village reflect the relationship between the residents and the surrounding environment as observed with the Sultanate of Palembang Darussalam. The buildings also reflect the relationship with Yemeni Arab migrants outside Indonesia such as those in Malaysia and Singapore. This means architecture is used as a sign of the socio- economic relations for the residents of Al-Munawar village.
Strategi Adaptasi Perubahan Iklim pada Kawasan Permukiman Berbasis Lahan Basah di Banjarmasin
Authors: Supar Evan Elianto , Razak Humairoh
Published: July 2024

Climate change has had massive impacts, and various programs have been attempted. However, the community has not been impacted. Settlements are vulnerable objects and potentially become sustainable best practices. It is necessary to study the strategies for adaptation to climate change impacts on a residential area. This research aims to identify the relationship between adaptation strategies and a sustainable approach from Green Building Council Indonesia (GBCI) Neighbourhood V1.0. This research was conducted in the Karang Mekar Area, Banjarmasin City. This study uses a qualitative method through the stages of collection and analysis of data, restatement, and conclusion. The research found applied the strategy of 1) Using shading; 2) House and field level engineering, 3) Using solar panels, and 4) using The TOD concept.
From Physical Models to Innovations: Technology Advances in Architectural and Civil Engineering
Authors: Gbran Hassan
Published: July 2024

This study delves into the profound impact of physical prototypes on engineering design. It explores their historical and ongoing relevance in advancing architectural and civil engineering. The author emphasizes the critical role of measurement prototypes in pioneering engineering endeavors, highlighting their importance in validating innovative designs and ensuring operational integrity and safety. Through illustrative examples from structural engineering and architectural acoustics, the study underscores the enduring significance of physical models in engineering innovation. It provides valuable insights into the symbiotic relationship between physical prototypes and engineering theory, shedding light on their multifaceted role in propelling engineering advancements. Ultimately, the analysis offers a nuanced understanding of the integral contribution of physical prototypes to the advancement of the engineering discipline
Perancangan Direksi Keet dan Hunian Sementara dengan Pendekatan Teritori Untuk Memperhatikan Privasi Pengguna
Authors: Wulandari Eva Mei , Dinapradipta Asri , Defiana Ima
Published: July 2024

The creation of territories on site offices and temporary housing can affect the activities within them. This study explores the criteria for territories in site offices and temporary housing through user comfort and privacy. Qualitative research methods were used, with data collection through primary and secondary sources. Primary data was collected from field studies on projects in East Java, while secondary data was obtained from literature studies. The results of this study are design criteria that can be used as a reference for designing site offices and temporary housing with a territory concept, focusing on spatial comfort and privacy. The study shows that design criteria for spatial comfort are dimensions appropriate to body size to create optimal movement space in limited areas, whereas design criteria for privacy involve specific functions and clear circulation without disturbing users’ privacy.
Anatoly Ivanovich Martynov (October 22, 1937 — May 19, 2024)
Authors: Editorial Article
Published: July 2024

.
Radioscapholunate Arthrodesis for Management of Madelung Deformity
Authors: Barrientos Alberto , Margalit Adam , Ayalon Omri
Published: July 2024

Case:

A 32-year-old woman with bilateral Madelung deformity presented with severe pain and arthritis of the radiocarpal and distal radioulnar joints. At final follow-up, 17 months for the left and 12 months for the right wrist, she had excellent functional results with no pain. Range of motion was 30° of flexion and 30° of extension with full pronosupination.

Conclusion:

There is paucity in the literature regarding salvage procedures in adults with this deformity. We demonstrate treatment with distal ulna excision and an radioscapholunate arthrodesis. This procedure may be indicated in Madelung deformity and proximal radiocarpal and distal radioulnar joint arthritis.
TKR in Hemophilic Arthropathy: A Combination of Special Surgical Considerations and Novel Nonacog Beta Pegol
Authors: Chhetri Prakrit , Sood Chetan , Shakya Amir Ratna , Jung Khatri Kishor
Published: July 2024

Case:

A 29-year-old man with hemophilia B presented with advanced arthropathy of the right knee, resulting in poor knee functional scores and difficulties in his livelihood. The patient underwent total knee replacement while receiving nonacog beta pegol factor IX by a multidisciplinary approach.

Conclusion:

Hemophilias commonly result in end-stage hemophilic arthropathy of the joints at a young age that may warrant joint replacement surgeries. This case report illustrates the surgical protocol of total knee arthroplasty in a patient who received a long-acting factor IX preparation.
Local and systemic biodistribution of a small molecule radiopharmaceutical probe after transcatheter embolization and intra-arterial delivery in a porcine orthotopic renal tumor model
Authors: Rice Samuel L. , Muñoz Fernando Gómez , Benjamin Jamaal L. , Alnablsi Mhd Wisam , Quadri Rehan , Osborne Joseph R. , Beets-Tan Regina
Published: July 2024

Background
Small molecule biomacromolecules target tumor specific antigens. They are employed as theranostic agents for imaging and treatment. Intravenous small molecule radioligands exhibit rapid tumor uptake and excretion.
However, systemically administration for peptide receptor radionuclide therapy brachytherapy lacks the therapeutic index to completely treat solid tumors beyond palliation. We study intra-arterial delivery with tumor embolization of a small molecule as a means to deliver local intertumoral brachytherapy for curative internal ablation.
Results
¹⁸F-Fluorodeoxyglucose (FDG) was used as a surrogate for a small molecule theranostic agent in a porcine renal tumor model, this tumor model is not known to specifically express human tumor antigens, but the model demonstrates similar vascularity. Angiography and micron particle embolization of the tumor arterioles was performed in a renal tumor model. Significantly more, 2x to 4x more tumor uptake, for study intra-arterial. administration compared to i.v (%ID/g = 44.41 ± 2.48 vs 23.19 ± 4.65 p= 0.0342* at 1 min and 40.8 ± 2.43 vs 10.94 ± 0.42 p=0.018* 10 min). At later time points, up to 120 mins after injection, washout of the tracer from the tumor was observed, but percent injected dose per gram remained elevated, with 3x higher concentration of FDG with intra-arterial administration compared to intravenous, but the difference was not statistically significant. Trend towards diminished systemic percent injected dose per gram measured in the blood, liver, kidney, spleen, muscle, and urine for study intra-arterial compared to intravenous administration.
Conclusion
Combining intra-arterial administration of a small molecule radioprobe surrogate with embolization of the tumor's arterioles extending the time for interaction of the drug within the tumor by diminishing flow out of the tumor via the efferent capillaries significantly increases the first pass uptake of the SM drug within a tumor and decreased the radiation to normal non-tumor tissues when compared to intravenous injection of the same drug. The minimally invasive drug delivery allows tumor specific theranostic treatment of renal tumors with a brachytherapy absorbed dose of radiation that is potentially curative.
Modelling of the Structural Properties of Concrete With Rice Husk Ash (Rha) as a Biocomposite Using Osadebe Second Degree Polynomials.
Authors: Akeke Godwin A. , Udokpoh U. U. , Nnaji Charles C
Published: July 2024

The demand for concrete is increasing in tandem with population growth and urbanization. Cement is an important ingredient in concrete production. Cement is a major contributor to global carbon dioxide emissions during its manufacturing processes. Therefore, sustainable alternatives to normal cement are required for the production of sustainable concrete. Rice husk ash has proven intriguing properties as a sustainable alternative for producing green and eco-friendly concrete. Because the laboratory work needed to assess its properties is both time-consuming and complex, regression models can be effectively used to predict the properties of concrete containing rice husk ash. Using Osadebe's second-degree polynomial equation, a mathematical optimization model for predicting the compressive, tensile, and flexural strengths of RHA concrete was developed in this study. The developed model may be used to compute compressive, tensile, and flexural strengths based on the proportions of four constituents in a given mix. Also, a favourable comparison may be drawn between the model and experimental responses. Furthermore, the statistical analysis summary revealed that the model-predicted values were in good agreement with the experimental values. Lastly, some of the optimized mixes attain strength values that are suitable for use in structural or load-bearing concrete.
Optimizing Urban Sustainability: TheEffects of Green Infrastructure and its Application in Indian Cities
Authors: Pachouri Vikrant , Kothari Prafull
Published: July 2024

This research investigates the effectiveness and application of green infrastructure in urban contexts within five major Indian cities: Some of the major cities are Delhi, Mumbai, Bangalore, Chennai, and Kolkata. The research design also incorporates both qualitative and quantitative approaches including a literature review, case studies, surveys with 1000 residents, and interviews with 25 urban planning experts. The research findings show that green infrastructure has a positive impact on the environment, economy, and society. Green roofs in Delhi minimize stormwater and energy use whereas green belts and mangrove replanting in Mumbai lessen flood impacts and improve air quality. Bangalore’s rainwater harvesting has increased groundwater recharge while Chennai’s urban wetlands help in flood control and reduction in temperature. Kolkata’s community gardens not only enhance the green area of the city but also contribute to local food production. The analysis of the result is conducted and the results demonstrate the F-statistics value as 8.48 and the p-value as 9.90 x 10− 7. But there are some issues to consider including maintenance costs, funding, and public awareness. Thus, the study comes up with recommendations that green infrastructure should be supported through policies, community involvement, and integrated urban planning as crucial for sustainable urban development in India.
The Sit-Up Test to Assess Orthostatic Hypotension in Individuals with Spinal Cord Injury: Validity and Reliability
Authors: Wecht Jill Maria , Maher Matthew T , Lirshblum Steven C. , Escalon Miguel X. , Weir Joseph P
Published: July 2024

Due to decentralized autonomic nervous system function, individuals with spinal cord injury (SCI) are reported to have an increased prevalence of orthostatic hypotension (OH). Diagnosis of OH is made with active standing or tilt table testing, with limited the use in individuals with SCI. An alternative approach to assess OH is the sit-up test which involves passive repositioning from the supine to the seated position. The purpose of this study was to determine the reliability and validity of the sit-up test in a large, diverse group of individuals with SCI. A total of 166 participants completed two sit-up tests, 119 individuals with SCI and 47 uninjured controls and 36 individuals who completed the sit-up tests also underwent a head-up tilt test. The mean difference in change in BP from sit-up test 1 to sit-up test 2 was not significant for either SBP or DBP, and neither level nor severity of injury contributed significantly to the reliability assessments. However, the reliability assessments showed disappointing results with generally low interclass correlation coefficients (ICC) values and large standard error of measurement (SEM). Comparison of the BP responses between the sit-up test and the head up tilt showed good sensitivity and specificity, with positive predictive values of 75% for both SBP and DBP. Prevalent BP instability likely contributed to the poor reliability of the sit-up test, but the test is easy to perform with good sensitivity and specificity and a high likelihood ratio for the valid assessment of OH in individuals with SCI.
Heart and Lung Point-of-Care Ultrasonography Tutoring in Internal Medicine: a Randomized Controlled Trial
Authors: Leidi Antonio , Krauer Juliette , Soret Guillaume , Parent Thibault , Marti Christophe , Meyer Philippe , Juillerat André , Bex Stijn , Suh Noémie , Rouyer Frédéric , Siegenthaler Nils , Grosgurin Olivier
Published: July 2024

Background: In recent years, point-of-care ultrasonography (POCUS) has been integrated into internal medicine practice with most curricula composed of a single course. Despite competency acquisition during the course, a significant decline in proficiency occurs in the subsequent weeks due to a lack of regular practice and training. This study aims to evaluate the impact of a structured POCUS tutoring, on POCUS use and skills retention at 6 months.
Methods: In this randomized controlled trial, internal medicine residents were enrolled after completing a practical course focused on heart and lung ultrasonography. Residents assigned to the intervention group were paired with a tutor, and time slots were scheduled for bedside direct supervision over the following 6 months. The primary outcome was the proportion of residents who successfully completed at least 25 POCUS examinations six months after inclusion. Secondary outcomes included self- and blinded-expert-assessed POCUS competency skills.
Results: Between January and May 2022, 23 residents were included in the study. The intervention significantly increased the proportion of participants reaching the primary outcome (70% versus 0%; p<0.001) with a median of 27 (interquartile range, IQR, 6 to 44) supervised examinations performed versus 0 (IQR 0 to 0) in intervention and control arm respectively; p<0.001. After 6 months, proficiency was higher for most heart imaging but not for lung imaging, as assessed through self-assessment by participants or independently by blinded experts.
Conclusions: Structured POCUS supervision significantly enhances the number of POCUS examinations and proficiency at 6-months, particularly in applications requiring greater visuospatial skills.
A rare case of IgDλ/λ free Multiple Myeloma as a virtuous example of collaboration between clinical activity and laboratory medicine
Authors: Sasso Mauro , Germano Candida Rosaria , Staffella Vanda , Ceci Luigi , Tarantini Giuseppe
Published: July 2024

BACKGROUND: IgD Multiple Myeloma (MM) is a rare hematological neoplasm characterized by an aggressive course compared to the other isotypes of Myeloma; its laboratory findings are usually anemia, presence of Bence Jones protein (BJP), hypogammaglobulinemia, lack of a monoclonal peak on serum protein electrophoresis (SPE), renal failure, osteolytic lesions.
CLINICAL CASE: A 72-year-old man with bone pain presented to the Hematology Unit because of bone pain and laboratory tests showing a Monoclonal Component type λ and normocytic anemia (Hemoglobin level 10.5 g/dL). A conventional skeletal radiography of cranium and spine in toto was performed and showed multiple discopathies, sacroiliitis and bilateral coxarthrosis.
RESULTS: Laboratory tests performed in Clinical Pathology and Microbiology Unit showed hypogammaglobulinemia, acute renal failure (s-creatinine 2.86 mg/dL, eGFR 39,01 mL/min), s-calcium 9.3 mg/L, serum Free Light Chains ratio 0,0044, presence of BJP type λ, a peak of 19.7 g/L in SPE. Serum immunofixation (sIFE) performed by anti-IgD and λ free serum showed a monoclonal IgDλ band and a monoclonal λ free band. Nuclear Magnetic Resonance (NMR) imaging showed cervical-dorso-lumbar and pelvic osteolysis, while osteomedullary biopsy showed a 70% plasma cell infiltration. Symptomatic IgDλ MM was diagnosed: the symptomatic findings where anemia and bone disease.
CONCLUSION: The 72-year-old patient of our clinical case presented at diagnosis some features commonly present in IgD MM. In this case, the laboratory adopted new diagnostic protocols in order to make a correct diagnosis; the hematological parameters, SPE and sIFE were monitored for 56 months.
New therapies have been shown to improve outcomes in this disease and a recent revision of recommendations has contributed to good clinical practice for patients with relapsed/refractory MM.
Pro-Inflammatory Effects of Inhaled Great Salt Lake Dust Particles
Authors: Cowley Jacob M. , Deering-Rice Cassandra E. , Lamb John G. , Romero Erin G. , Almestica-Roberts Marysol , Serna Samantha N. , Sun Lili , Kelly Kerry E. , Whitaker Ross T. , Cheminant Jenna , Venosa Alessandro , Reilly Christopher A.
Published: July 2024

Background: Climatological shifts and human activities have decimated lakes worldwide. Water in the Great Salt Lake, Utah, USA is at near record lows which has increased risks for exposure to windblown dust from dried lakebed sediments. Formal studies evaluating the health effects of inhaled Great Salt Lake dust (GSLD) have not been performed despite the belief that the dust is harmful. The objectives of this study were to illustrate windblown dust events, assess the impact of inhaled dust on the lungs, and to identify mechanisms that could contribute to the effects of GSLD in the lungs.
Results: An animation, hourly particle and meteorological data, and images illustrate the impact of dust events on the Salt Lake Valley/Wasatch front airshed. Great Salt Lake sediment and PM2.5 contained metals, lipopolysaccharides, natural and anthropogenic chemicals, and bacteria. Inhalation and oropharyngeal delivery of PM2.5 triggered neutrophilia and the expression of mRNA for Il6, Cxcl1, Cxcl2, and Muc5ac in mouse lungs, was more potent than coal fly ash (CFA) PM2.5, and more cytotoxic to human airway epithelial cells (HBEC3-KT) in vitro. Induction of IL6 and IL8 was replicated in vitro using HBEC3-KT and THP-1 cells. For HBEC3-KT cells, IL6 induction was variably attenuated by EGTA/ruthenium red, the TLR4 inhibitor TAK-242, and deferoxamine, while IL8 was attenuated by EGTA/ruthenium red. Inhibition of mRNA induction by EGTA/ruthenium red suggested roles for transition metals, calcium, and calcium channels as mediators of the responses. Like CFA, GSLD and a similar dust from the Salton Sea in California, activated human TRPA1, M8, and V1. However, only inhibition of TRPV1, TRPV3, and a combination of both channels impacted cytokine mRNA induction in HBEC3-KT cells. Responses of THP1 cells were partially mediated by TLR4 as opposed to TRP channels and mice expressing a “humanized” form of TRPV1 exhibited greater neutrophilia when exposed to GSLD via inhalation.
Conclusions: This study suggests that windblown dust from Great Salt Lake and similar lake sediments could pose a risk to humans via mechanisms including the activation of TRPV1/V3, TLR4, and possibly oxidative stress.