bluuebunny/crossref_metadata_2025 huggingface dataset:
Monitoring Shoreline and Land Use/Land Cover Changes in Sandbanks Provincial Park Using Remote Sensing and Climate Data
Authors: Kouhgardi Esmaeil , Hemati Mohammadali , Shakerdargah Elaheh , Shiri Hodjat , Mahdianpari Masoud
Published: November 2022

Climate change-driven forces and anthropogenic interventions have led to considerable changes in coastal zones and shoreline positions, resulting in coastal erosion or sedimentation. Shoreline change detection through cost-effective methods and easy-access data plays a key role in coastal management, where other effective parameters such as land-use/land-cover (LULC) change should be considered. This paper presents a remotely sensed shoreline monitoring in Sandbanks Provincial Park, Ontario, Canada, from 1984 to 2021. The CoastSat toolkit for Python and a multilayer perceptron (MLP) neural network classifier were used for shoreline detection, and an unsupervised change detection framework followed by a postclassification change detection method was implemented for LULC classification and change detection. The study assessed the recent coastal erosion and accretion trends in the region in association with spatiotemporal changes in the total area of the West and East Lakes, the transition between LULC classes, extreme climate events, population growth, and future climate projection scenarios. The results of the study illustrate that the accretion trend apparently can be seen in most parts of the study area since 1984 and is affected by several factors, including lake water-level changes, total annual precipitations, sand movements, and other hydrologic/climatic parameters. Furthermore, the observed LULC changes could be in line with climate change-driven forces and population growth to accelerate the detected accretion trend in the East and West Lakes. In total, the synergistic interaction of the investigated parameters would result in a greater accretion trend along with a lower groundwater table amid even a low carbon scenario. The discussed findings could be beneficial to regional/provincial authorities, policymakers, and environmental advocates for the sustainable development of coastal communities.
“I Immediately Blurred the Map of Everyday Life”, or the Recent Situation in the Appraisal Business
Authors:   Institute for Economic Strategies, Pobyvaev Sergey A. ,   Financial University under the Government of the Russian Federation.
Published: November 2022

The methodology for studying the strategic potential of valuation companies in Russia is based on the use of the Strategic Matrix of the Company software package, the algorithm of which involves the analysis of qualitative and quantitative indicators that allow building a complete profile of the company and giving a scenario forecast of its development. The main qualitative parameters taken for analysis include such as the degree of innovation and differentiation of services, the level of competition and the position of the company in the market, the priority of certain strategic goals in the company's activities, the effectiveness of motivation, corporate culture, the ability to quickly access the necessary resources
Features and Directions of Real Estate Valuation for the Purposes of State Economic Policy in the Context of Digitalization
Authors:   Research Financial Institute of the Ministry of Finance of the Russian Federation., Gubanov Roman S.
Published: November 2022

The article deals with topical issues of digital cadastral accounting, calculating the value of a real estate object in the context of the dynamics of market indicators. The statistics of the distribution of Russian cities by the indicator of the average level of real estate prices in the context of market types in 2020 are reflected. An approach to the formation of reports on the results of real estate valuation is proposed.
The Failure of Automated System of Planning Calculations (ASPC) as Theoretical and Methodological Mistake of the State Planning Committee: Analysis and Conclusions
Authors:   Lomonosov Moscow State University., Zhiryakov Vitalii A.
Published: November 2022

Real economic growth and development is no longer conceivable without digital revolution achievements. However, to this day, introduction of these achievements into the national economy is far from being the easiest task, since its solution entails a number of methodological and conceptual problems. That was also understood in the USSR after the end of the Second World War, when society for the first time in history thought about improving the national economy management based on the latest technological solutions. The project of automating economic planning, officially called the automated system of planning calculations (ASPC) became a new unique solution of that time. Such a system was supposed to bring Soviet planning to a qualitatively higher level, however, due to theoretical and methodological contradictions contained in the concept, the Soviet digitalization project initially went the wrong way and was never brought to its logical conclusion. The question is whether it was possible to implement ASPC with the same capacities, but with the different theoretical and methodological basis.
Dominance of National Systems of Higher Education
Authors:   Lomonosov Moscow State University., Suslova Irina P. , Korostyleva Irina I. ,   Lomonosov Moscow State University., Spektor Stanislav V. ,   Lomonosov Moscow State University.
Published: November 2022

The theory of economic dominance in a multilevel economy, developed by Blokhin A.A. and Lomakin-Rumyantsev I.V., has been actively tested by researches on different markets since 2019 — the distribution of players in the markets allows to formulate different strategies for their development. This article is a development of studies devoted to the study of competition in the education market and presents the result of economic dominance of national higher education systems in the international market. This research aims to analyze the subject areas of social sciences and management, for further identifying dominance in the QS ranking. The sample consists of 58 QS subject rankings for 2018–2021. The main instrument is the SV-matrix (strength/variety). The analysis outlines areas of subject ratings where there is dominance of national educational systems and characterizes its level. In addition, an interpretation of the situation when constructing the SV matrix, where Lind index shows boundary values when determining dominant group size. The SV matrix gives valid results and allows both qualitatively and quantitatively assessing the positions of countries in educational rankings. Analysis using SV-matrix made it possible to identify 8 out of 15 subject areas, in which there is clear dominance and determined positions of Russian universities relative to the dominant group. The hypothesis of United States presence in the dominant group in most areas of social sciences and management was confirmed, however, several subjects were defined, where the higher education system of anther countries were in the lead. The scientific novelty of this study lies in the proposal and testing of a method for assessing the level of dominance of national educational systems in the international education market. The SV matrix allows to analyze the positions of different countries in the international educational space, both in dynamics and in statics (to assess the level of competitiveness of national educational systems); to understand theoretically the level of differentiation of national educational systems in certain subject ratings; to assess the concentration (barriers to enter the rating) and the strength of competition (how strongly the players differ) of subject areas.
The Avant-Guarde Stratification of Nations
Authors:   Mining Institute, NUST MISIS., Ponomariov Vladimir P.
Published: November 2022

In modern economic thinking, there is an unclear division of the population into rich, poor and middle class. This structuring originated in the time of Euripides and Aristotle. However, there is still no general method for determining the parameters of the middle class, although the dynamics of growth and development of national economies significantly depends on it. The author proposes to stratify the population by the criterion of GDP per capita, calculated by purchasing power parity. At the same time, the author determines the parameters of the avant-garde, middle and rear-guard strata of the nation on the route of economic development using the proposed development gamma scale.
Scientific Basis of Economic Strategies
Authors:   International Research Institute for Advanced Systems., Golubev Vladimir S.
Published: November 2022

The scientific basis of energy strategies is represented by the sciences of natural-humanitarian synthesis that study the "nature-man-society" system: ergodynamics, system theory of capital, the science of harmony, synthetic evolutionary ecology. Method of their construction is a deductive one: from the laws of socio-natural development to the society and an individual. National wealth, or country (national) capital, is the main indicator of the state of societies. It is considered as the structural energy (energy potential) of societies in value terms. Country capital is calculated as the sum of physical, human, social and natural capital. Natural capital includes reproducible (ecocapital) and non-reproducible (paleocapital) components. Index of the life quality of societies (changes from 0 to 1) is the arithmetic mean of the ratio of the private capital production of each society to the maximum values of the production of these capitals among all the societies under consideration. The purpose of economic strategies is to ensure the systemic progress of societies. It is implemented with the growth over time of the specific (per person) country capital and, accordingly, the quality of life index. Maximum progress takes place with harmonious resolution of the opposites existing in societies. The article proposes a method for calculating country capital, its components and the life quality index.
Racing Without Looking Back
Authors:   MGIMO University, Ageev Aleksandr I. ,   Institute for Economic Strategies
Published: November 2022

Opening address of the Editor-in-chief
Innovation Cluster as an Institution for Developing Russia's Innovative Economy
Authors:   Lomonosov Moscow State University., Kostin Svyatoslav V.
Published: November 2022

Supply support policy, which is becoming more and more relevant in Europe and America due to overheated demand, is also relevant for Russia. At the same time, active growth of the state’s information capabilities can be used to mutually coordinate the goals of social and economic development under condition of the focus on integrated development of the innovation environment and in case when the innovation cluster is the optimal institution. First of all, it forms the structure of innovative industry with a wide layer of small and medium-sized businesses, reducing transaction costs. Secondly, the combination of competition and cooperation in a cluster is especially advantageous in the innovation culture of Russia, which is distinguished by the intrinsic value of mastery and innovative community. Thirdly, the cluster makes possible to resolve a conflict between digital platforms and local economy, using the advantages of digitalization and localization to meet mutual interests that contributes to the public welfare growth.
Rigorousness of the Hydrogen Strategy
Authors:   Gubkin University., Kortikov Artem V. , Il'kovskii Konstantin K. ,   Gubkin University
Published: November 2022

The main criterion for classifying hydrogen is the amount of carbon emissions generated during its production. Since only green hydrogen, received from renewable energy sources (RES), can be considered a fuel with a minimal carbon footprint, the article examines the question of to what extent the hydrogen strategies of various countries may be regarded as decarbonized. A typological approach is applied and a framework is established to define the stringency of green hydrogen regulation in national hydrogen strategies based on three parameters: fossil fuel penalties, hydrogen certification and exceptional technology development. According to these parameters, countries are classified into groups depending on the degree of regulation severity. The problems, associated with increasing the strictness of regulation for hydrogen production both at the national and international levels, are identified.
Sketching on Viruses
Authors:   Doctor of Biological Sciences, Zahidov Sabir T.
Published: November 2022

“Viruses stand on the borders of the living and non-living. On the one hand, they have all the attributes of a living thing: they are born, assimilate, die and, to please those who are accustomed to seeing movement in the living, move. But in chemical laboratories viruses are sometimes transformed into powder, which in appearance doesn’t differ much from a mineral that has been ground into powder. And this "viral" powder is not born, does not assimilate, does not die and, of course, if it moves, then only for the same reasons as granulated sugar. But once the virus powder, sleeping in a “dead sleep” for a long time, longer than the “sleeping princess”, is “transferred” into a living environment, for example, tobacco mosaic virus is put onto tobacco leaves, the powder in the plant cells will turn into tailed living beings. If a virus is alive, why doesn't it die when it turns into a corpse? If it is lifeless, why, having resurrected, it lives like all living things?” (N.K. Koltsov)
Only a Sacred National Idea will Save Russia
Authors:   The Izborsk Club., Bolshakov Vladimir I.
Published: November 2022

In analyzing the essence of the Russian national idea and the way of reviving spiritual and moral values, it is necessary not only to understand the causes and events that destroyed the Soviet state, but also to build a program of overcoming the systemic crisis based on our own historical experience in the historical and philosophical context. The power perceived in Ancient Russia, along with the adoption of Christianity, gained sacredness from Byzantium, which absorbed all the experience of Antiquity, Ancient Judea and the Roman Empire. The article formulates a historiosophical concept, defines the systemic crisis of statehood, and outlines a way out of the time of troubles through the genuine institution of democracy in Russia, the Zemsky Sobor (Russian People's Assembly), which is inherent in Russian civilization.) from the indigenous classes: the clergy and the peasantry, the officers and the Cossacks, the merchants and the resurgent Russian entrepreneurship, the workers and peasants, the scientific and engineering and creative elite.
Who Wants to be the First? From Competition to Service by Faith in Christ
Authors:   Church of St. Alexander Nevsky, Styrov Maxim ,   Institute of Socio-Economic and Energy Problems of the North, Federal Research Center ",   Komi Scientific Center of the Ural Branch of the Russian Academy of Sciences",   Pitirim Sorokin Syktyvkar State University
Published: November 2022

The article dwells on spiritual prerequisites and weaknesses of the modern conception of competition, as well as the possibility of transforming it from the point of view of Truth — the Orthodox faith in Jesus Christ, the Son of God.
Modeling the Consequences of a Nuclear Strike
Authors:   Central Economics and Mathematics Institute of the Russian Academy of Sciences., Makarov Valerii L. , Ageev Aleksandr I. ,   MGIMO University; MEPhI; International Research Institute for Advanced Systems, Bakhtizin Albert R. ,   Central Economics and Mathematics Institute of the Russian Academy of Sciences, Grabchak Evgenii P. ,   Ministry of Energy of the Russian Federation, Loginov Evgenii L. ,   Ministry of Energy of the Russian Federation
Published: November 2022

The risks of increasing international tension have sharply exacerbated the possibility of a nuclear conflict. The main geopolitical players in the international arena have actually recognized the possibility and even expediency of using nuclear weapons. In this context, the need to simulate the consequences of a nuclear strike in order to prepare for emergencies of a critical nature has become extremely urgent. The present article analyzes foreign experience of using digital simulators to this end. The authors outline Russian views on applying agent-based simulation methods for this purpose in the analysis of non-military (civilian) aspects of a nuclear blow effects.
2022, January — May: Russia in the Context of Slowing Down Socio-economic Development
Authors:   Institute of Economy of the Russian Academy of Sciences, Frenkel Alexander A. , Tikhomirov Boris I. ,   Institute of Economy of the Russian Academy of Sciences, Surkov Anton A. ,   Institute of Economy of the Russian Academy of Sciences
Published: November 2022

Changing of a conjuncture index of “Economic strategy” (CIES) for five months of 2022 is considered. The contribution of indicators of supply and demand in CIES is estimated. The analysis of industrial production is carried out.
Neoliberalism and its criticism by well-known defenders of the market order
Authors:   Department of practical psychology Omsk state pedagogical University, Il'in A.N.
Published: November 2022

The article critically examines the philosophy of neoliberalism. The author finds a wide destructive potential of neoliberalism for society and the state. The privatization promoted by the neoliberal ideology, the withdrawal of the state from the economic and social spheres, the rejection of protectionism have a negative impact on the development of the economy and on the standard of living of society. The economic freedom exalted by liberal philosophy makes it possible for speculative activity to develop. Ethical foundations are undermined by the substitution of personal responsibility for social protection. Liberal philosophy creates numerous myths, with the help of which an ideological defense of the growth of inequality and many other socially unacceptable results of the functioning of the liberal economic and political system is built. The article proves the mythological nature of liberal theses about free competition and equality of chances, about hard work as the key to success. The unreasonableness of pairing neoliberalism with democracy is postulated. Anti-democracy seems to be inherent in neoliberalism. The social disfunctionality of neoliberal reforms and their anti-national character are proved. The growth of inequality, the loss of sovereignty by states, the expansion of poverty, the development of the corporate sector (including socially irresponsible speculative capital) is a natural result of the functioning of the neoliberal project. This project is a methodology in the hands of transnational business for opening up the economies of sovereign states and enslaving societies. The growth of inequality in the world is associated with the policy of neoliberal reforms. The modern “postmodern economy” is characterized by virtualization, simulacrization, and financial speculation. In the article, the greatest attention is paid to the development of the speculative financial sector, which has become widespread due to the implementation of neoliberal policies. Financial speculation is considered as a socially harmful phenomenon, bearing its share of responsibility for the growth of inequality. Special attention in the article is paid to the recently expressed positions of analysts who have long stood on the ideological ground of defending neoliberalism. However, it is interesting that due to the disastrous results that this project brings to humanity, they have in some way changed their attitude towards it.
Global dollar democracy Part one. Swamp of dollar abundance
Authors:   Independent Researcher, Republic of Belarus, Mach V.Ya.
Published: November 2022

Research on the problems of political economy, the dynamics of the global financial system and its relationship with intercultural interactions. According to the author, in order to move to a better organization of the world community as a whole, it is necessary to completely nullify all world convertible currencies, followed by the use of uniform and equivalent banknotes in international trade.
Model of interaction of higher educational institutions with the communications industry in the professional student training
Authors:   Faculty of Advertising, Journalism, Psychology and Art, Department of Theory of Advertising and Mass Communications, Moscow University for the Humanities, Boroday A. D.
Published: November 2022

In modern conditions, a system of interaction between higher educational institutions and enterprises of various profiles has developed. It is considered as a necessary condition for achieving high quality professional training of bachelors and masters for various sectors of the economy, culture, and education. The communications industry has grown rapidly over the past three decades. In the last period, the highlights and trends are related to digital communication. Internet communications dominate the advertising services market. It is important that this speed of development is accompanied by trends in professional education. In various articles on the topic of interaction between higher educational institutions and enterprises, researchers offer models of cooperation between higher educational institutions and production. We are interested in following these trends in the cooperation between higher educational institutions and the communications industry.
Physical world and its system-scale levels
Authors:   Institute for Fundamental and Applied Research, Moscow University for the Humanities, Voskoboinikov A. E.
Published: November 2022

The author shows that it is more and more difficult to obtain new objective data about the physical world. After all, modern scientific practice has an increasingly indirect character. We are increasingly moving away from our familiar realm of reality. Studying the microcosm, the scientist has to overcome ever greater challenges. In addition to the "instrumental mediation" of scientific knowledge, there is also a "theoretical mediation". The latter can be understood as all the growing theoretical constructions that describe the object under study. The materials presented in the article may be useful in the study of the discipline "Concepts of Modern Natural Science".
Features of professional communication in the entertainment industry
Authors:   Strategies for Effective Communications, Faculty of Advertising, Journalism, Psychology and Art, Moscow University for the Humanities, Glukhova L. V.
Published: November 2022

The article analyzes modern communication practices in the entertainment industry, namely, in the field of show business. The means of professional communication, which contribute to the organization of proper interaction with the media, are considered. Specific technical, social and communication problems associated with the promotion of brands in the entertainment industry are highlighted. The article considers how the company's website and the personal website of a brand personality are beneficial for promoting a personal brand. The materials of the article may be useful in the training in Advertising and Public Relations.
Transformation of communication practices in the context of the UN Sustainable Development Agenda
Authors:   Department of Theory of Advertising and Mass Communications, Moscow University for the Humanities, Mukhaev R. T.
Published: November 2022

The article considers the mechanism for constructing a new post-COVID reality within the framework of the UN sustainable development agenda, the implementation strategy of which was proposed by K. Schwab in the green economy paradigm. The proposed scenario for constructing a new social order radically transforms communication practices in the new system of digital dominance.
The effectiveness of the use of natural mineral additives in the diets of young pigs
Authors:   Federal State Budgetary Educational Institution of Higher Education “Northern Trans-Ural State Agricultural University”, Russia, Tyumen, Yarmots G. A. , Belenkaya A. E ,   Federal State Budgetary Educational Institution of Higher Education “Northern Trans-Ural State Agricultural University”, Russia, Tyumen
Published: November 2022

Currently, mineral additives attract special attention of specialists in the fi eld of animal feeding, both in our country and abroad. At the same time, it is advisable to use local raw materials for production such as chalk, sapropel, zeolites, bentonites, etc. Natural zeolites have unique adsorption, ion exchange, catalytic properties, improving the digestibility of feed nutrients, and have a positive eff ect on the physiological state of animals, increase live weight gain, increase the livability of young animals. The purpose of the work was to determine the eff ectiveness of the use of natural mineral additives in the diets of young pigs. The infl uence of natural mineral additives of zeolite and bentonite on the digestibility of nutrients in the diet, the metabolism of nitrogen, calcium, phosphorus and the growth rate of young pigs during rearing and fattening was studied. The positive effect of the studied additives on the digestibility of nutrients in animal diets, morphological and biological parameters of blood, nitrogen metabolism, mineral substances and growth intensity has been established. In animals of the 2nd experimental group, who received bentonite as a mineral additive the absolute gain in live weight for the entire period of the experiment was 93,26 kg. Compared with herdmates of the 1st experimental group, the absolute gain in the piglets of the 2nd experimental group was by 4,22 kg or 4,7 % more, and the superiority over herdmates of the control group was by 13,11 kg or 16,4 % (P < 0,05). Thus, feeding zeolite and bentonite in the diets during the rearing and fattening of pigs contributes to increasing the digestibility of feed and the accessibility of nutrients in the diet, as well as increasing their productive traits.
La portée de l’Accord de Prespa relatif à la dénomination constitutionnelle de l’ancienne République yougoslave de Macédoine
Authors: Chercheneff Lena
Published: November 2022

L’entrée en vigueur de l’accord de Prespa marque le règlement définitif du différend opposant la Grèce à l’ancienne République yougoslave de Macédoine (ARYM), au sujet de la dénomination constitutionnelle adoptée par ce nouvel État lors de son indépendance en 1991. Cet accord, qui entérine le nouveau nom de «République de Macédoine du nord » , met fin à l’accord intérimaire conclu en 1995 entre les deux États. La résolution diplomatique de la question du nom permet ainsi de lever les obstacles à la participation de l’ARYM aux organisations internationales dont la Grèce est membre, et de renforcer la coopération bilatérale entre les deux pays. Les dispositions de ce traité de bon voisinage et de coopération amicale sont directement façonnées par l’objet et les circonstances du litige interétatique, expliquant la singularité de l’accord au regard de la pratique internationale.
L’Union européenne et le Sahara occidental : le rôle du droit européen dans l’effectivité des obligations internationales erga omnes
Authors: Cassella Sarah
Published: November 2022

The European Union has been dealing for many years with the sensitive issue of conclusion and enforcement of economic agreements with Morocco allowing the exploitation of Western Sahara natural resources. The ECJ has managed to preserve these treaties while affirming that their scope can’t be extended to this territory because of EU obligations stemming from the right of self-determination of the sahraoui people. The Commission and the Council chose nonetheless to negotiate with Morocco amendements explicitly including Western Sahara within their scope, thus provoking new legal actions. This litigation shows the potential contribution of the EU to the efficacy of international erga omnes obligations belonging to different fields. The declaration of unlawfulness of international agreements according to EU law would also affect the acts of secondary legislation implementing them, the law of Member States and finally rights and duties of their companies.
Punir ensemble : les réactions militaires du 14 avril 2018 à l’emploi d’armes chimiques à Douma (Syrie)
Authors: D'Argent Pierre
Published: November 2022

En réaction à l’emploi allégué d’armes chimiques à Douma en avril 2018, les États-Unis, la France et le Royaume-Uni ont mené un raid aérien visant à punir le gouvernement syrien et à le dissuader de recommencer. Cet article revient sur les éléments factuels relatifs à l’emploi allégué d’armes chimiques et son attribution au gouvernement syrien, ainsi que sur le débat concernant la licéité des frappes aériennes au regard du droit international et la configuration de l’éventuelle responsabilité internationale en découlant.
Affaire de la frontière maritime entre le Timor-Leste et l’Australie : rapport et recommandations de la Commission de conciliation, 9 mai 2018
Authors: Hermet Alexandre
Published: November 2022

On 9 March 2018, the Commission of conciliation in the case of the maritime boundary between Timor-Leste and Australia issued its Report and Recommendations. This Report is worthy of interest on at least two facets. First, it provides an accurate insight of the proceedings of conciliation, in spite of the secret surrounding them. On this point, the differences between adjudication and conciliation appear clearly : the former seeks to settle unilaterally a dispute when the latter aims to conduct the parties to an agreed solution. Second, it allows a perception with rare precision of the process by which two States achieve a maritime delimitation and of the choice of a joint development concept of maritime natural resources.
Les dessous de l’architrave : une singularité de l’architecture française à la Renaissance
Authors: Pauwels Yves
Published: November 2022

Beginning in the 1530s, columns are commonly used on façades, with often strongly protruding entablatures that give the cantilevered architraves an impression of instability. Architects adopted original solutions that had no classical precedents and very few Italian models, and which were not treated in theoretical works. Either they placed consoles of varying form under the architrave, following an established Romanesque practice, or they treated the architrave like voussoirs by decorating the soffit with coffers, a form borrowed from the decoration of the soffits of arches, underscoring the recourse to a specifically French art of the line. T﻿h e singular and sometimes paradoxical formulas, encountered especially in provincial or peripheral examples, are characteristic of the difficulties facing French architects when adapting the new classical language to a particular moment in the history of the building arts.
Mapping the Transcriptome Underpinning Acute Corticosteroid Action within the Cortical Collecting Duct
Authors: Loughlin Struan , Costello Hannah M. , Roe Andrew J. , Buckley Charlotte , Wilson Stuart M. , Bailey Matthew A. , Mansley Morag K.
Published: November 2022

Key Points

We report the transcriptomes associated with acute corticosteroid regulation of ENaC activity in polarized mCCDcl1 collecting duct cells.

Nine genes were regulated by aldosterone (ALDO), 0 with corticosterone alone, and 151 with corticosterone when 11βHSD2 activity was inhibited.

We validated three novel ALDO-induced genes, Rasd1, Sult1d1, and Gm43305, in primary cells isolated from a novel principal cell reporter mouse.

Background

Corticosteroids regulate distal nephron and collecting duct (CD) Na+ reabsorption, contributing to fluid-volume and blood pressure homeostasis. The transcriptional landscape underpinning the acute stimulation of the epithelial sodium channel (ENaC) by physiological concentrations of corticosteroids remains unclear.

Methods

Transcriptomic profiles underlying corticosteroid-stimulated ENaC activity in polarized mCCDcl1 cells were generated by coupling electrophysiological measurements of amiloride-sensitive currents with RNAseq. Generation of a principal cell-specific reporter mouse line, mT/mG-Aqp2Cre, enabled isolation of primary CD principal cells by FACS, and ENaC activity was measured in cultured primary cells after acute application of corticosteroids. Expression of target genes was assessed by qRT-PCR in cultured cells or freshly isolated cells after the acute elevation of steroid hormones in mT/mG-Aqp2Cre mice.

Results

Physiological relevance of the mCCDcl1 model was confirmed with aldosterone (ALDO)-specific stimulation of SGK1 and ENaC activity. Corticosterone (CORT) only modulated these responses at supraphysiological concentrations or when 11βHSD2 was inhibited. When 11βHSD2 protection was intact, CORT caused no significant change in transcripts. We identified a small number of ALDO-induced transcripts associated with stimulated ENaC activity in mCCDcl1 cells and a much larger number with CORT in the absence of 11βHSD2 activity. Principal cells isolated from mT/mG-Aqp2Cre mice were validated and assessment of identified ALDO-induced genes revealed that Sgk1, Zbtbt16, Sult1d1, Rasd1, and Gm43305 are acutely upregulated by corticosteroids both in vitro and in vivo.

Conclusions

This study reports the transcriptome of mCCDcl1 cells and identifies a small number of ALDO-induced genes associated with acute stimulation of ENaC, including three previously undescribed genes.
Scattering Inversion Study for Suspended Label-Free Lymphocytes with Complex Fine Structures
Authors: Zhang Lu , Wang Huijun , Liu Jianyi , Chen Shuang , Yang He , Yang Zewen , Zhang Zhenxi , Zhao Hong , Yuan Li , Tian Lifang , Zhong Bo , Liu Xiaolong
Published: November 2022

Objective and Impact Statement
. Distinguishing malignant lymphocytes from normal ones is vital in pathological examination. We proposed an inverse light scattering (ILS) method for label-free suspended lymphocytes with complex fine structures to identify their volumes for pathological state.
Introduction
. Light scattering as cell’s “fingerprint” provides valuable morphology information closely related to its biophysical states. However, the detail relationships between the morphology with complex fine structures and its scattering characters are not fully understood.
Methods
. To quantitatively inverse the volumes of membrane and nucleus as the main scatterers, clinical lymphocyte morphologies were modeled combining the Gaussian random sphere geometry algorithm by 750 reconstructed results after confocal scanning, which allowed the accurate simulation to solve ILS problem. For complex fine structures, the specificity for ILS study was firstly discussed (to our knowledge) considering the differences of not only surface roughness, posture, but also the ratio of nucleus to the cytoplasm and refractive index.
Results
. The volumes of membrane and nucleus were proved theoretically to have good linear relationship with the effective area and entropy of forward scattering images. Their specificity deviations were less than 3.5%. Then, our experimental results for microsphere and clinical leukocytes showed the Pearson product-moment correlation coefficients (PPMCC) of this linear relationship were up to 0.9830~0.9926.
Conclusion
. Our scattering inversion method could be effectively applied to identify suspended label-free lymphocytes without destructive sample pretreatments and complex experimental systems.
Biocompatibility of an experimental endodontic sealer (Resil) in comparison with AH26 and AH-Plus in rats: An animal study
Authors: Ashraf Hengameh , Shafagh Parviz , Mashhadi Abbas Fatemeh , Heidari Soolmaz , Shahoon Hossein , Zandian Amin , Aghajanpour Leila , Zadsirjan Saeede
Published: November 2022

Background. This experimental study sought to assess the biocompatibility of Resil, an experimental epoxy resin-based sealer, in comparison with AH26 and AH-Plus sealers in rats. Methods. Twelve male Wistar rats weighing 400 to 500 grams were evaluated in this experimental study. Four polyethylene tubes containing Resil, AH-Plus, AH26 sealers, and an empty tube were implanted subcutaneously in rats. The degree of inflammation, type of inflammatory cells present, foreign body reaction, quality of connective tissue, and presence of fibrotic capsule were evaluated histopathologically at 7 and 30 days after implanting the tubes to assess the biocompatibility of sealers. Data were analyzed using the Chi-square test. Results. At 7 days, the degree of inflammation in Resil group was almost similar to AH26 group, and 66.7% of rats showed moderate inflammation. AH-Plus group showed less inflammation than Resil and AH26 (50% of rats showed low degree of inflammation), At 30 days, the inflammatory status of all groups was the same, and 83.3% of rats showed very low degree of inflammation. The inflammatory response during the experiment decreased from day 7 to day 30 in all groups. The neutrophil count (P=0.00), fibrotic capsule (P=0.01) and the amount of granulation tissue (P=0.05) significantly decreased from day 7 to day 30 in Resil group. Conclusion. Resil sealer showed appropriate biocompatibility at 7 and 30 days after subcutaneous implantation in rats, comparable to AH26 and AH-Plus. Clinical studies are required to confirm these results.
Bond strength of conventional versus modified methods for Class IV restorations in primary incisors: An in vitro study
Authors: Aslaminabadi Naser , Halimi Tabrizi Zohreh , Golsanamlou Ozra , Estaki Zohreh , Jamali Zahra
Published: November 2022

Background. Aesthetic restorations of severely decayed anterior primary teeth are challenging due to the small size of the teeth and the large pulp chambers. Therefore, this study evaluated and compared the tensile and shear bond strengths of conventional versus modified methods (slot technique) of Cl IV restorations in primary incisors. Methods. A total of 120 extracted intact maxillary primary central and lateral incisors were divided into two groups. In group A, conventional Cl IV cavities were prepared. In group B, after conventional cavity preparation, four and three incisal slots were prepared on the incisal edges of the central and lateral incisors, respectively. All the teeth were restored using composite resin, and then the tensile and shear bond strengths were evaluated. Results. A statistically significant increase in the tensile bond strength of restorations was recorded in the modified technique compared to the conventional method (P=0.001). Although an increase in the shear bond strengths was found in the modified method, the value did not reach a statistically significant level (P=0.158). The most frequent fracture type was adhesive in the conventional group and cohesive in the modified group, considering the tensile and shear bond strength tests. In both groups, the highest average tensile bond strength was recorded in teeth with the cohesive fracture in dentin, and the lowest average was seen in the adhesive type. Conclusions. Incisal slots could increase the tensile bond strengths of Cl IV composite resin restorations in primary teeth.
The Correlation between New Serological Markers and Disease Phenotype and Activation in Inflammatory Bowel Disease
Authors: Yorulmaz Elif , Adalı Gupse , Yorulmaz Hatice , Taşan Güralp , Gürses Seval , Ayaş Mehmet Ramazan , Tuncer İlyas
Published: November 2022

Background: The aim of the study is to assess the correlation between a new antibody panel that is developed against glycans on Crohn’s disease (CD) and ulcerative colitis (UC) differentiative diagnosis and disease properties. Methods: In the study, 137 CD and 122 UC patients and 90 controls were included. Anti-saccharomyces cerevisiae IgG (ASCA), anti-laminaribioside IgG (ALCA), anti-chitobioside IgA (ACCA), and anti-mannobioside IgG (AMCA) were tested in serum. Results: While at least 1 of the other 3 serological markers was positive in 89% of ASCA-positive patients, at least 1 of the other 3 serological markers was positive in 77% of ASCA-negative patients. Positivity ratio for a single anticarbohydrate was ALCA 18 (22%), ACCA 5 (12%), and AMCA 16 (23%). A significant correlation was found between ASCA positivity (P<0.001) in operated patients and between ASCA, ALCA, and ACCA positivity (P<0.05) in patients with stricturing and fistulizing CD. According to the ROC analysis, ASCA was found to have the highest area under the curve (0.70-0.82) (correlation coefficient interval 95%). A significant correlation was found between ASCA, ALCA, and ACCA positivity and high serum antibody levels and disease activation (P<0.05). Conclusion: ASCA, ALCA, and ACCA were found to be correlated with the disease complication and activation in CD. ASCA and ALCA were determined as the best markers in the differentiation between CD and UC.
The Effect of Gluten-Free Diet Duration on Body Mass Index of Iranian Patients with Celiac Disease
Authors: Asri Nastaran , Taraghikhah Nazanin , Baniasadi Reihaneh , Ishaq Sauid , Rezaei-Tavirani Mostafa , Sadeghi Amir , Ehsani-Ardakani Mohammad-Javad , Jahani-Sherafat Somayeh , Asadzadeh Aghdaei Hamid , Rostami-Nejad Mohammad
Published: November 2022

Background: A gluten-free diet (GFD) is the only effective treatment of celiac disease (CD) that is associated with body mass index (BMI) changes. This study aimed to determine how GFD duration affects the BMI of Iranian patients with CD. Methods: In this prospective study, 215 patients with CD, who were on a GFD, were categorized into three groups according to the duration of compliance to GFD: 1. patients with less than 6 months of diet, 2. Patients who had a diet for 6 months to 2 years, and 3. patients with more than 2 years of diet. The BMI changes were assessed before and after adherence to the GFD. Results: Most patients’ weight remains in the same BMI category during different courses of GFD adherence. Patients who were underweight showed significant changes in their BMI following the diet in less than 6 months (P=0.033) and more than 2 years (P<0.001), and the number of weight gain cases increased over time. Conclusion: There is a need for careful, updated, and personalized nutrition management of patients with CD in different periods of the diet. Conducting similar studies with larger sample sizes in different regions can lead to providing expert dietary counseling for patients with CD.
Systematic Review and Meta-analysis of TP53, HER2/ERBB2, KRAS, APC, and PIK3CA Genes Expression Pattern in Gastric Cancer
Authors: Ghojazadeh Morteza , Somi Mohammad Hossein , Naseri Amirreza , Salehi-Pourmehr Hanieh , Hassannezhad Sina , Hajikamanaj Olia Arash , Kafshdouz Leila , Nikniaz Zeinab
Published: November 2022

Background: With a global prevalence of about 10%, gastric cancer is among the most prevalent cancers. Currently, there has been an ongoing trend toward investigating genetic disruptions in different cancers because they can be used as a target-specific therapy. We aimed to systemically review some gene expression patterns in gastric cancer. Methods: The current systematic review was designed and executed in 2020. Scopus, PubMed, Cochrane Library, Google Scholar, web of knowledge, and Science Direct were searched for relevant studies. A manual search of articles (hand searching), reference exploring, checking for grey literature, and seeking expert opinion were also done. Results: In this review, 65 studies were included, and the expression pattern of HER2/ ERBB2, ER1/Erb1/EGFR, PIK3CA, APC, KRAS, ARID1A, TP53, FGFR2 and MET was investigated. TP53, APC, KRAS, and PIK3CA mutation cumulative frequency were 24.8 (I2=95.05, Q value=525.53, df=26, P<0.001), 7.2 (I2=89.79, Q value=48.99, df=5, P<0.001), 7.8 (I2=93.60, Q value=140.71, df=9, P=0.001) and 8.6 (I2=80.78, Q value=525.53, df=9, P<0.001) percent, respectively. Overexpression was investigated for HER1/ Erb1/EGFR, PIK3CA, APC, KRAS, ARID1A, TP53, CCND1, FGFR2, MET and MYC. The frequency of TP53 and HER2/ERBB2 were 43.1 (I2=84.06, Q value=58.09, df=9, P<0.001) and 20.8 (I2=93.61, Q value=234.89, df=15, P<0.001) percent, respectively. Conclusion: More research is encouraged to investigate the genes for which we could not perform a meta-analysis.
IMPLEMENTATION OF 360-DEGREE FEEDBACK AND SAW FOR DECISION SUPPORT SYSTEM OF ACHIEVING TEACHER'S RECOMMENDATION
Authors: Ginting Novita BR , Syarif Zulkarnaen Noor , Maesaroh Mamay , Jaenudin Jejen , Widhyaesteoty Dahlia , Yusup Muhamad Alfian , Ningrum Leny Tritanto
Published: November 2022

Education requires quality teacher resources in the current era of industry 4.0 and society 5.0. Teachers act as educators, teachers, mentors, directors, trainers, assessors, and evaluators. Students must have critical thinking competencies, creativity and innovation, interpersonal and communication skills, teamwork and collaboration, and self-confidence.  At SMK Yasbam, the selection process for outstanding teachers is carried out every year. The problem faced is that the selection process is still assessed, selected, and determined by the school principal only, so there is still a process that is deemed not transparent, accountable, and fair. To make the assessment process fairer, try using the 360-degree feedback method, a multi-source assessment, and then weighting the performance value using the Simple Additive Weighting method to obtain recommendations for outstanding teachers. Respondents consisted of principals, fellow teachers, students, and themselves (the assessed teachers). Furthermore, combining these two methods is applied in a decision support system to make the assessment process and selection of outstanding teachers more objective.
Analisis Struktur Modal, Likuiditas, dan Return On Equity terhadap Nilai Perusahaan dengan Kebijakan Dividen sebagai Pemediasi
Authors: Anggraini Gusnita
Published: November 2022

Penelitian ini bertujuan untuk mengetahui analisis struktur modal, likuiditas, return on equity, terhadap nilai perusahaan dengan kebijakan dividen sebagai variabel intervening. Objek penelitian yang dilakukan adalah perusahaan manufaktur yang terdaftar di Bursa Efek Indonesia periode 2017 sampai 2021. Populasi yang digunakan dalam penelitian ini adalah seluruh perusahaan manufaktur yang terdaftar di Bursa Efek Indonesia periode 2017 sampai 2021 yaitu sebanyak 193 perusahaan. Jenis data yang digunakan dalam penelitian ini adalah data kuantitatif dengan menggunakan metode purporsive sampling. Sampel pada penelitian ini perusahaan manufaktur yang terdaftar di Bursa Efek Indonesia sebanyak 20 perusahaan. Hasil penelitian ini menunjukkan bahwa (1) Struktur Modal berpengaruh signifikan terhadap Kebijakan Dividen. (2) Likuiditas berpengaruh signifikan terhadap Kebijakan Dividen (3) Return On Equity berpengaruh signifikan terhadap Kebijakan Dividen. (4) Struktur Modal berpengaruh signifikan terhadap terhadap Nilai Perusahaan. (5) Likuiditas berpengaruh signifikan terhadap terhadap Nilai Perusahaan. (6) Return on Equity tidak berpengaruh signifikan terhadap terhadap Nilai Perusahaan. (7) Kebijakan Dividen berpengaruh signifikan terhadap terhadap Nilai Perusahaan. (8) Kebijakan Dividen tidak dapat memediasi hubungan antara Struktur Modal terhadap Nilai Perusahaan. (9) Kebijakan Dividen tidak dapat memediasi hubungan antara Likuiditas terhadap Nilai Perusahaan. (10) Kebijakan Dividen tidak dapat memediasi hubungan antara Return on Equity terhadap Nilai Perusahaan.