bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengembangan Situs Web Untuk Promosi Warisan Budaya Lokal dan Pariwisata Berbasis Berita
Authors: Ramadhani Rachmad , Setiawan Eman
Published: June 2024

In the modern era dominated by technology and information, the development of news-based websites has emerged as a key element in supporting the promotion of tourism and cultural heritage in tourist destinations. This research investigates how news-based websites can be a key factor in enhancing tourism promotion, as well as the key elements that need to be considered to ensure their effectiveness in attracting visitor and supporting tourism destination promotional objectives. In addition, this research also examines methods for measuring the success of tourism and cultural promotion websites in achieving promotional objectives, including increasing the number of visitors and participation in cultural activities. The role of news content in enhancing website attractiveness and driving user interaction is also the focus of the analysis. Furthermore, this research explores users' experiences and their interactions with news-based websites in tourism. Factors influencing user preferences and participation are also analyzed to understand how to increase the effectiveness of news-based websites in the context of tourism and culture promotion. The results of this research provide important insights for the development and improvement of news-based tourism and culture promotion websites, as well as a greater contribution to sustainable tourism development and preservation of local cultural heritage.
Harmonia: Securing Cross-Chain Applications Using Zero-Knowledge Proofs
Authors: Belchior Rafael , Dimov Dimo , Karadjov Zahary , Pfannschmidt Jonas , Vasconcelos André , Correia Miguel
Published: June 2024

The field of blockchain interoperability plays a pivotal role in
blockchain adoption. Despite these advances, a notorious problem
persists: the high number and success rate of attacks on blockchain
bridges. We propose Harmonia, a framework for building robust, secure,
efficient, and decentralized cross-chain applications. A main component
of Harmonia is DendrETH, a decentralized and efficient zero-knowledge
proof-based light client. DendrETH mitigates security problems by
lowering the attack surface by relying on the properties of
zero-knowledge proofs. The DendrETH instance of this paper is an
improvement of Ethereum’s light client sync protocol that fixes critical
security flaws. This light client protocol is implemented as a smart
contract, allowing blockchains to read the state of the source
blockchain in a trust-minimized way. Harmonia and DendrETH support
several cross-chain use cases, such as secure cross-blockchain bridges
(asset transfers) and smart contract migrations (data transfers),
without a trusted operator. We implemented Harmonia in 9K lines of code.
Our implementation is compatible with the Ethereum Virtual Machine (EVM)
based chains and some non-EVM chains. Our experimental evaluation shows
that Harmonia can generate light client updates with reasonable latency,
costs (a dozen to a few thousand US dollars per year), and minimal
storage requirements (around 4.5 MB per year). We also carried out
experiments to evaluate the security of DendrETH. We provide an
open-source implementation and reproducible environment for researchers
and practitioners to replicate our results.
O querosene do discurso de ódio na fogueira da violência de gênero
Authors: Marinho Cristiane Maria
Published: June 2024

This article presents a reflection on the gender violence raised by Hate Speech, based on the thoughts of Judith Butler, as well as the concepts of gender and performativity. After initially presenting these concepts, the text focuses on explaining some of the different forms of gender violence, such as: sexual harassment; domestic; policy; moral harassment; homophobia; transphobia and femicide. Next, and as a result of the issues raised, the text continues reflecting on the possibilities of resistance and combating such violence.
Investigation of Retention Mechanism of B2 and B3 in Home-Made ZIC-HILIC Columns and Its Application for The Simultaneous Estimation in Multivitamin Tablets
Authors: Al-twaijri Omar Q. Mezher , Mohammed Jasim M. Hassan2  , Bashaer A. Al-Phalahy3
Published: June 2024

In the present study, the retention behavior of two vitamins (B2 and B3) was investigated using a zwitterionic hydrophilic interaction liquid chromatography technique (ZIC-HILIC) on two home-made columns, and two analytical methods for these vitamins were established as a result. Several chromatographic parameters were carefully investigated and optimized. The best separation was achieved on two new home-made columns (ZIC-1 and ZIC-3) employing acetonitrile/sodium acetate buffer as the mobile phase (40 mM, pH 4.75). The target vitamins were detected at 254 nm. In the ZIC-1 and ZIC-3 columns, the linear ranges of the target vitamins (B2 and B3) were 0.06-11.0 and 0.08-7.0 µg/mL, respectively. For both target vitamins, the detection and quantitation limits of the suggested methods were 0.011-0.055 and 0.033-0.166 µg/mL, respectively. They also showed high precision (RSD ≤ 0.93), linearity (r2 ≥ 0.9988), and recovery (between 99.0 and 101.71%). The suggested procedures have been validated and tested on multivitamin tablets, proving that they are suitable for analyzing food supplements for these tablets, and acceptable results were obtained for the study.
Prevalence and Histological Study of Oestrus ovis Larvae in Slaughtered Goat of Babylon City, Iraq
Authors: Adhem Noor-Aldeen , Al-Bermani Safaa M.
Published: June 2024

This study was carried out to investigate the prevalence of larval stage Oestrus ovis conducted during the period from September 2023 to the end of March 2024 at Babylon city, Iraq. 250 goats firstly were examined grossly and postmortem by longitudinally cutting with a manual saw, secondly, the collected larvae (45) were examined microscopically to measure its length and overall morphology. The total infestation rate was 26% (65/250). The highest rate of infestation was in female which was 44/150 (29.3%) while in male the infestation rate was 21/100(21%). The rate of infestation increases with the progression age of animal, older adult (over three years) was more susceptible to infestation was recorded 30/85(35.3%), while 17% (14/80) were in ages less than one year. Therefore, it showed a highly significant difference at (P<0.01). Furthermore, the histopathological sections of nasal cavity showed that Numerous mucous glands, thickening of epithelium, hyperplasia of blood vessels and severe Infiltration of inflammatory in goat infected with O.ovis larvae. In contrast, the uninfected goat showed moderate inflammatory cell infiltration in mucosal layer of nasal cavity and several dense glandular aggregates encircled by a dense network of elastic fibers. In conclusion, this study shows the important of O. ovis that infect goat in Babylon city, Iraq. Moreover, the morphology of all larval stage is similar except their measurement, color, and the shape of respiratory spiracles.
Evaluation of Interleukin-33, Interleukin-10 Levels in Rheumatoid Arthritis Patients on Long Term Therapy of Disease-Modifying Antirheumatic Drugs
Authors: Azeez Ali Mohsin , Dheep Israa Abdul Alwahid
Published: June 2024

Background: Rheumatoid arthritis is a prevalent, long-term, inflammatory autoimmune illness with a wide range of extra-articular symptoms that affects 0.24% of people worldwide. Finding new, RA-specific biomarkers may help in early diagnosis, treatment, and monitoring of the severity and response to therapy of the disease. Objective: Determining of (IL-33, IL-10) levels in blood of both patients on long term therapy, early diagnosis patients and healthy control groups by using ELISA technique. Method: A case-control study in the following study groups consisted of three group. Group 1 included (50) patients on medications (DMARDs), Group 2 included (50) early diagnosed patients without medication and group 3 included (50) healthy individuals. Result: The mean of serum IL-33 concentration was significantly difference in rheumatoid arthritis (157.15 ± 24.88) in treated patients, (513.11 ± 113.01), and in patients with early diagnosis (185.75 ± 30.71) compared to the healthy control group (P = 0.000). But Mean levels of serum IL-10 were 320.27 ± 37.82, 180.24 ± 12.68 and 493.80 ± 68.94 pg/ml in patients on treatment, early diagnosis patients and healthy control group respectively; the level was highly significant lower than in early diagnosis patients with RA in comparison with patient on treatment and healthy control and the IL-10 level in healthy control was highly significant higher than in Patients on treatment, but in Patients on treatment higher than in early diagnosis patients, (P = 0.000). Conclusion: IL-33 and IL-10 is regarded as a useful biomarker for the diagnosis of RA and for assessing the severity of the illness.
Postoperative Rhabdomyolysis after Otopoiesis Reconstruction of the Right Ear: Case Report and Review of the Literature
Authors: Targhi H. , Belhouss A. , Benaiych H.
Published: June 2024

Background: Otopoiesis, a technique for reconstructing the auricle, represents a real challenge for the surgeon due to the complexity of the structural and three-dimensional anatomy of this region. It is prone to postoperative complications, particularly in the case of prolonged operations, which can lead to complications such as rhabdomyolysis. Case Report: We report the case of a patient who developed rhabdomyolysis after reconstruction surgery on the right ear, amputated following an assault. Conclusions: Despite the advantages of free fibular flap surgery, clinicians must be aware of the risk of complications, as multiple factors can lead to rhabdomyolysis, such as the duration of the operation, the patient's position and pre-existing conditions such as diabetes and hypertension.
Uncommon Benign Disease of the Salivary Glands Necrotizing Sialometaplasia (NS): Review of the Literature and Serie of 2 Cases
Authors: Belhaj N. , Bencheikh R. , Benbouzid M. A. , Essakalli L. H.
Published: June 2024

Necotizing sialometaplasia (NS) is an uncommon self limiting commonly confused with malignant epithelial entities; the aim of this article is to report series of two cases of necrostizing sialometaplasia: the first case is in 45 year old women with clinical documentary; the second case is an 37 year old man. Data from an extensive review of literature including clinical; imaginologic and microscopic features are provided. Information on diagnostic and prognostic factors is offered and comprehensibly discussed.
Fuzzy Logic based Personalized Learning Navigator for Students
Authors: Sathyabama A. R. , B Vinayamanjari , L Janani
Published: June 2024

The student performance tracking system using fuzzy logic algorithm is designed to transform online education by addressing the challenges students face in personalized guidance, study scheduling and resource navigation. The objective of this project is to categorize students' marks as good, average, or bad, helping them understand their performance level in each subject. Using fuzzy logic, the marks of the students are categorized by comparing them with predefined membership functions and ranges for each category. Fuzzy logic provides an accurate evaluation of marks compared to manual categorization, considering various degrees of membership rather than fixed thresholds. This approach ensures a precise assessment of students' performance, providing the benefits of automated categorization over traditional manual methods. With the categorized marks the schedule is provided for each subject based on the range they have scored i.e., good, average, or bad providing with improvement in performance evaluation. Additionally, the student can get access to the online platforms offering free course materials relevant to each subject with just one click. It helps the students to track their progress, maintain a personalized timetable for learning and access the free courses in the same place.
Clinical Trial Management System using Blockchain for Secure and Efficient Record Keeping
Authors: Nalayini C. M. , Vishnupriya K. , Sruthinila D.
Published: June 2024

In today’s developing environment, there is always a need for upgradation to easier lifestyle among people. Technology has improved in almost all areas of concern to facilitate people’s work. But even today, there is no efficient tool for managing Clinical Trial records. Clinical Trial records management is considered to be an important job when it comes to discovery of new medicines into the market. It is important to monitor the behaviour medicines for different group of people, at different locations, different age groups and gender. Only when the medicine’s behaviour is known, it can be administered to patients of several concerns. There are various EHMS used in hospitals to manage their data. But it should also be noted that, it is important to secure the data from theft or modification. Using Blockchain technology is one of the best ways to secure data from theft or modification. Clinical Trial Management system using Blockchain can be an efficient way to store trial reports safe.
CIMENTAÇÃO DE COROAS DE CERÂMICA PURA EM DISSILICATO DE LÍTIO
Authors: Batista Santos Costa Fernanda Giovanna , Silva Souza Sarah Maria , De Sousa Macedo Cariorrana Vital , Muniz Mota Virna Gabriele , De Oliveira Gomes Maria Angélica , Silveira Santos Bárbara Sttephanny , Oliveira Passos Martins Clarice , Dória Costa Max
Published: June 2024

Toda restauração indireta precisa de um agente de cimentação que a mantenha em posição no dente preparado. A cimentação trata-se de um passo crucial para garantir a retenção, selamento marginal e durabilidade das restaurações. As coroas totalmente cerâmicas podem ser confeccionadas com materiais distintos, e o cirurgião-dentista deve fazer sua escolha observando e avaliando as condições iniciais do paciente, como exigência estética, qual unidade que será reabilitada, coloração que o substrato do elemento se encontra, situação do remanescente dentário, condições oclusais, tipo de cimento que será utilizado além da relação da restauração com os tecidos periodontais. Este artigo descreve um caso clínico de cimentação de coroas em cerâmica pura em dissilicato de lítio, discutindo aspectos relacionados e trazendo resultados satisfatórios em relação a reabilitação estética e funcional da paciente.
Study the Impact of Tourism on the Environment and Local Culture
Authors: Sameer Basrawi Mohammed
Published: June 2024

Tourism is a dynamic and rapidly growing industry that plays a pivotal role in shaping economies, societies, and cultures around the world. However, the expansion of tourism activities often brings with it a range of environmental and socio-cultural impacts that can profoundly influence destination areas. This study aims to investigate the multifaceted impact of tourism on the environment and local culture in [Riyadh], utilizing a case study approach
The Impact of E-Commerce on Consumer Behaviour: A Comparative Analysis of Traditional and Online Shopping Patterns
Authors: Singla Arun
Published: June 2024

This study investigates the influence of e-commerce on consumer behavior by conducting a comparative analysis of traditional and online shopping patterns. With the rapid growth of online retail platforms, understanding how consumers' shopping behaviors differ between traditional brick-and-mortar stores and online platforms is crucial for businesses and policymakers alike. Using a combination of qualitative and quantitative methods, including surveys, interviews, and data analysis, this research examines various aspects of consumer behavior, such as purchase decision-making processes, product preferences, and satisfaction levels, across different shopping environments.
CORRELAÇÃO DE INDICADORES DO ESTADO NUTRICIONAL DE PACIENTES COM NEOPLASIA PULMONAR EM UM HOSPITAL UNIVERSITÁRIO, BELÉM - PA
Authors: Marigliani Nunes Ana Raquel , Matos de Pinho Costa Priscila , De Souza Barreto Denise , Peres Rocha Jucileide , De Souza Torres Rosileide , Da Silva Guterres Aldair
Published: June 2024

Objetivo: Correlacionar os indicadores do estado nutricional de pacientes com neoplasia pulmonar atendidos em um Hospital Universitário de Belém - Pa. Métodos: Estudo descritivo, transversal e observacional, realizado com 36 pacientes diagnosticados com neoplasia pulmonar, de ambos os sexos, com faixa etária acima de 18 anos, atendidos em um Hospital Universitário de Belém - PA. Os dados foram coletados por meio de questionários. O estado nutricional foi avaliado por meio de parâmetros antropométricos e bioquímicos. Foi aplicada a análise de correlação de Pearson com nível de significância de 5% (p=0,05). Resultados: Em relação ao perfil antropométrico, constatou-se que dos 36 pacientes analisados, 44,4% apresentaram eutrofia e 44,4% baixo peso, segundo o Índice de Massa Corporal. De acordo com a Circunferência da Panturrilha 87,5% dos idosos apresentaram desnutrição. Constatou-se desnutrição em 72,2%, 83,4% e 72,2%, segundo o %Prega Cutânea Tricipital, %Circunferência do Braço e %Circunferência Muscular do Braço, respectivamente. A maioria 52,8% e 61,1%, apresentava alteração nos valores de Hemácia e Hemoglobina, respectivamente. Houve correlação positiva e significativa entre as seguintes variáveis: IMC, %CB, %CMB, %PP, Hemácia e Hemoglobina. Conclusão: A correlação positiva e significativa entre os parâmetros antropométricos e bioquímicos demonstra que o comprometimento nutricional pode processar-se de forma diretamente proporcional nos diversos parâmetros nutricionais no paciente oncológico, podendo acarretar em diminuição da tolerância ao tratamento oncológico e um pior prognóstico.
USE OF LITHIUM DISILICATE VENEERS AND CROWNS IN ELDERLY PATIENTS:CASE REPORT
Authors: Élida Lucia Ferreira Assunção  , Lucas Gabriel de Melo Franco  , Bárbara Souza Mello  , Pedro Henrique Soares Aguiar  , Izaldi Teixeira Pereira  , Juracy Magalhães da Silveira
Published: June 2024

Introduction: Dental planning is fundamental in complex rehabilitations, restoring function and aesthetics through fixed metal-free restorations. Objectives: The objective of this study was to report an aesthetic and functional biological approach to a complex clinical case, restoring function and aesthetics, reestablishing the vertical dimension of occlusion by replacing tooth loss and an integrative review of the literature. Case report: Patient GEF, 70 years old, male, was admitted to the Dental Prosthesis clinic - Funorte, and his main complaint was “my teeth are small and worn out”. After undergoing clinical evaluation and carrying out complementary imaging exams (panoramic radiography), the following plan was proposed: upper wax-up; lower removable partial denture (RPD) – increase and restoration of the vertical dimension of occlusion (DVO); single crowns made on dental elements 14, 15, 21, 22, 23, 24 and 25 and Fixed Partial Prosthesis with 3 elements on teeth (11 to 13) Installation of fiberglass posts on elements 13 and 14; Filling and preparation core for full crown and inter-occlusal registration, impression with dense addition silicone followed by fluid addition silicone, wax try-in and cementation. Conclusion: Dental planning is essential to achieve favorable results, increasing OVD can be carried out successfully, as long as there is correct diagnosis and planning, the use of metal free prostheses have excellent aesthetic properties, which allows achieving a more natural result .
A APLICABILIDADE DO ÁCIDO HIALURÔNICO E DA TOXINA BOTULÍNICA NA HARMONIZAÇÃO OROFACIAL : UMA REVISÃO NARRATIVA
Authors: Cynthia Angélica Santos de Araújo  , Francielly Fernandes Pereira de Morais  , Ana Paula Moro Quinteiro  , Wiesty tamara Alves da Silva  , João Carlos da Silva  , Ana Paula Granja Scarabel Nogueira Bella  , Estefaní Araújo Feitosa  , Viviane de Cássia Bicalho Poeis  , Caio César Lima de Moura  , Gislene Paulovski  , Neucileny Melo Barbosa  , Aline Vieira Nascimento Priesnitz  , Ivan Silva Andrade  , Walber Freitas de Almeida  , Valeska Camargo Lacerda  , Vitória Laura Cavalari Rinaldi  , Fernanda scharf  , Rosa Ines Barbosa  , Noemi Celerino dos Anjos  , Ana Catarina Soares
Published: June 2024

Esta revisão narrativa objetivou atualizar a comunidade acadêmica sobre o uso da toxina botulínica e do ácido hialurônico na harmonização orofacial. Teve como questão norteadora “O que há de atual sobre a aplicabilidade do ácido hialurônico e da toxina botulínica na Harmonização Orofacial?”. As estratégias de busca foram estruturadas a partir de DeCS/MeSHterms e para a seleção dos artigos foram usadas as palavras-chave: “orofacial harmonization”, “botulinum toxins”, “hyaluronic acid” nas bases de dados MEDLINE/PubMed, SciElo e Google Academic. A mesma estratégia de busca foi aplicada na busca manual. E, após avaliação dos artigos recuperados, na luz dos critérios de elegibilidade resultou em 29, onde pode-se concluir que ambos os produtos apresentam biocompatibilidade versatilidade e excelência nos resultados, características que ratificam a indicação na harmonização facial, e o reestabelecer da autoestima e jovialidade ao paciente.
CEFALEIA RECORRENTE POR ABUSO DE ANALGÉSICOS E SEUS IMPACTOS NA QUALIDADE DE VIDA
Authors: Ana Tayná Belém Alves  , Helena Teófilo Mendonça  , Camila Vitória Morais Madeira  , Emmily Mayara Santos Lima  , Suzane Belém Sampaio  , Paolla Maria da Silva Martins  , David Alan Santos Mendes  , Gabriel Lucena de Sousa Reis  , Matheus Gurgel Saraiva
Published: June 2024

O estudo possui como objetivo identificar os efeitos da cefaleia recorrente por abuso de analgésicos e seus impactos na qualidade de vida. A presente pesquisa trata-se de uma revisão integrativa da literatura. Para tal estudo, foi construída a seguinte pergunta norteadora: “Quais os efeitos da cefaleia recorrente por abuso de analgésicos e seus impactos na qualidade de vida.?”. Na elaboração da pergunta norteadora e na busca de evidências científicas utilizou-se a estratégia PICO, que possui o seguinte significado: P de paciente ou população; I de intervenção ou indicador; C de comparação ou controle e O de outcome que significa o desfecho clínico, resposta ou resultado sendo o que se espera encontrar nos estudos selecionados. Após a combinação dos descritores nas bases de dados e a aplicação rigorosa dos critérios de inclusão e exclusão, foram elegidos 12 artigos. A presente revisão integrativa mapeou a produção científica sobre os efeitos da cefaleia recorrente por abuso de analgésicos e seus impactos na qualidade de vida. Apesar da classificação atual das cefaleias, ainda não existe uma certeza absoluta sobre a relação causal entre o uso de determinadas substâncias e o desenvolvimento da dor de cabeça. Algumas substâncias têm o potencial de desencadear dores de cabeça em pacientes que já sofrem de cefaleias primárias, como enxaqueca, cefaleia do tipo tensional ou cefaleia em salvas, enquanto outras foram associadas a dores de cabeça mesmo em pessoas que geralmente não as têm. Agentes tóxicos, como o monóxido de carbono, apresentam dificuldades na investigação sistemática, enquanto outras substâncias, como o óxido nítrico, foram utilizadas especificamente para induzir experimentalmente a cefaleia. A cefaleia recorrente por abuso de analgésicos representa um problema de saúde pública de considerável relevância, dada a sua alta prevalência e os significativos impactos negativos na qualidade de vida dos pacientes. Este estudo destacou como o uso excessivo de analgésicos pode agravar a frequência e a intensidade das dores de cabeça, interferindo nas atividades diárias e profissionais, e contribuindo para o aumento do absenteísmo.
About the calculation of turbulent flows in pipelines using in-line smooth-walled coatings
Authors: Денисов М.Е. , Михеева А.А.
Published: June 2024

Предложена модификация классической модели Кармана для турбулентного трения, которая отличается отказом от условия бесконечности производной скорости на стенке. Вместо этого, в рамках предлагаемого подхода, для полированных, химически травленых труб и применяемых внутритрубных гладкостных покрытий, представлено граничное условие на первую производную скорости на стенке, которое зависит от числа Рейнольдса в трех характерных зонах и относительной шероховатости. Также представлено решение задачи о турбулентном течении несжимаемой вязкой жидкости в гладких и шероховатых трубах. Проведен анализ различий между течениями в трубах с равномерно-зернистой и технической шероховатостями, на основе предложенной модификации модели турбулентного трения. С достаточной точностью аппроксимировали известные интегральные и локальные экспериментальные данные по течениям в трубах во всем диапазоне чисел Рейнольдса и параметров относительной шероховатости.

The article proposes a modification of the classical Karman model for turbulent friction, is proposed, which differs in rejecting the condition of infinity of the velocity derivative on the wall. Instead, within the framework of the proposed approach, for polished, chemically etched pipes, and applied in-pipe smooth coatings, a boundary condition for the first derivative of velocity on the wall is presented, which depends on the Reynolds number in all three characteristic zones and relative roughness. The solution of the problem of turbulent flow of incompressible viscous fluid in smooth and rough pipes is also presented. The analysis of the differences between flows in pipes with uniformly granular and technical roughness is carried out, based on the proposed modification of the turbulent friction model. Known integral and local experimental data on flows in pipes over the entire range of Reynolds numbers and relative roughness parameters were approximated with sufficient accuracy.
Assessment of criteria for vibration parameters of marine 4-stroke engines based on the rules of classification societies
Authors: Герасиди В.В. , Лисаченко А.В. , Белый А.А.
Published: June 2024

В работе выполнен анализ нормативных документов классификационных обществ по контролю параметров вибрации судовых 4-х тактных двигателей в эксплуатации. Достоинством контроля состояния по сигналам вибрации является не только возможность получения информации о предполагаемом отказе машины к определенному моменту времени и планирования мер по предотвращению этого отказа. В основу анализа входило рассмотрение критериев оценки параметров вибрации и их уровней, для контроля и диагностики выявления неисправностей двигателей, связанных с повышенной вибрацией. В методику экспериментального исследования входило рассмотрение влияния воздействия действующих сил, а также описаны резонансные колебания при изменении частот вращения современных двигателей. Рассмотренные научные труды и опыт авторов, доказывают о необходимости корректировки уровней и мест контроля вибрации на существующих современных двигателей, установленных на различных видах опор и условий эксплуатации. Выполненные исследования позволили объединить и сгруппировать критерии вибрации с учетом рекомендаций заводов изготовителей по контролю и выявить основные диагностические признаки для выявления причин повышенной вибрации двигателей. Проводимые исследования судовых энергетических установок, на основе применения безразборных методов диагностики морских судов в эксплуатации, лежат в основе системы управления автономных судов.

The paper analyzes the regulatory documents of classification societies for the control of vibration parameters of marine 4-stroke engines in operation. The advantage of monitoring the condition by vibration signals is not only the possibility of obtaining information about the expected failure of the machine by a certain point in time and planning measures to prevent this failure. The analysis was based on the consideration of criteria for evaluating vibration parameters and their levels, for monitoring and diagnosing engine malfunctions associated with increased vibration. The methodology of the experimental study included consideration of the influence of the action of acting forces, and also described resonant oscillations when changing the rotational speeds of modern engines. The reviewed scientific works and the experience of the authors prove the need to adjust the levels and places of vibration control on existing modern engines installed on various types of supports and operating conditions. The performed studies made it possible to combine and group vibration criteria taking into account the recommendations of manufacturers for control and to identify the main diagnostic signs to identify the causes of increased vibration of engines. The ongoing research of marine power plants, based on the use of non-selective methods of diagnostics of marine vessels in operation, are the basis of the control system of autonomous vessels.
Obtaining a diesel indicator diagram by in-cylinder pressure change rate digital signal processing
Authors: Коньков А.Ю. , Демаков К.К. , Трунов А.И.
Published: June 2024

В работе рассмотрена методика получения индикаторной диаграммы на основе расчетного анализа сигнала скорости изменения давления в цилиндре. Исследована возможность определения фаз закрытия клапанов газораспределительного механизма анализом высокочастотной составляющей измеряемого сигнала. Показано влияние частоты дискретизации на точность определения давления в цилиндре. В основе измерительного канала использовались пьезоэлектрический датчик Kistler 6613EQ13-C и преобразователь “ток-напряжение”, выполненный на основе схемы, предложенной А. В. Буэно с соавторами. В качестве эталонных датчиков применялись датчик давления ДДГ200/700 производства НПК «Гарант» и датчик линейного перемещения Gefran PY-2-F-025-S01M. Экспериментальные исследования, проведенные для двух типов четырехтактных среднеоборотных судовых дизелей, показали удовлетворительное совпадение основных результатов индицирования для экспериментального и эталонного измерительных каналов, а также подтвердили взаимосвязь между высокочастотной составляющей сигнала скорости изменения давления и работой клапанов газораспределительного механизма с учетом выявленных недостатков.

The paper discusses the method of obtaining the indicator diagram by calculating the in-cylinder pressure change rate signal. The authors investigated the possibility of determining the closing phases of gas distribution mechanism valves by analyzing the high-frequency component of the measured signal. It is shown how sampling frequency affects the accuracy of pressure determination in the cylinder. The measuring channel was based on the Kistler 6613EQ13-C piezoelectric sensor, and the "current-voltage" transducer based on the scheme proposed by A. V. Bueno et al. The reference sensors were the DDG 200/700 pressure sensor by the RPC “Garant” and the Gefran PY-2-F-025-S01M linear displacement sensor. Experimental studies carried out for two types of four-stroke medium-speed marine diesel engines showed a satisfactory convergence of the main indication results for the experimental and reference measurement channels and confirmed the relationship between the high-frequency component of the pressure change rate signal and the operation of the valve of the gas distribution mechanism, considering the identified shortcomings.
On modeling the development and extinguishing of fire during ferry transportation of railway trains
Authors: Таранцев А.А. , Маринов М.Л. , Коновалов И.Н.
Published: June 2024

В статье рассмотрена проблема моделирования пожаров железнодорожных составов, перевозимых паромами. Показано, что такие пожары могут принимать каскадный характер, т.е. возгорание одного вагона может привести к возгораниям соседних вагонов, в результате чего масштаб пожара значительно возрастает. Показано, что такие пожары на паромах в плавании могут привести к трагическим последствиям, в том числе и к масштабному экологическому инциденту ввиду низкой огнестойкости корпуса судна и невозможности оказания оперативной помощи извне. Для описания процессов горения и тушения вагонов применён математический аппарат цепей Маркова с непрерывным временем. Получены аналитические выражения для характерных сценариев пожара и приведены соответствующие расчётные оценки вероятностей состояния парома. Сделаны выводы о целесообразности дальнейших исследований в части моделирования пожароопасных ситуаций с разными типами перевозимых вагонов и совершенствования соответствующих нормативных документов.

The article considers the problem of modeling fires of railway trains transported by ferries. It is shown that such fires can take on a cascading character, i.e. the ignition of one car can lead to fires of neighboring cars, as a result of which the scale of the fire increases significantly. It is shown that such fires on ferries during navigation can lead to tragic consequences, including a large-scale environmental incident due to the low fire resistance of the vessel's hull and the inability to provide operational assistance from the outside. To describe the processes of burning and extinguishing wagons, the mathematical apparatus of Markov chains with continuous time is used. Fire Analytical expressions for typical fire scenarios are obtained and corresponding estimates of the probabilities of the ferry condition are given. Conclusions are drawn about the expediency of further research in terms of modeling fire-hazardous situations with different types of transported wagons and improving the relevant regulatory documents.
Wpływ mączniaka prawdziwego zbóż i traw na uprawy pszenicy w kontekście zmian klimatu
Authors: Pietrusińska Aleksandra , Żurek Monika
Published: June 2024

Pszenica (Triticum aestivum L.) to jedno z kluczowych zbóż na świecie. Z powodu ogromnej roli pszenicy w światowym systemie żywnościowym, zmiany w wolumenie jej produkcji, jakości oraz dostępności mogą mieć znaczący wpływ na bezpieczeństwo żywnościowe na świecie. Wysokość globalnej produkcji i jakość plonów pszenicy jest silnie uzależniona od zmian klimatu, których efektem jest spadek areałów upraw zbóż i dostępności wody pitnej przy jednoczesnym spadku opłacalności produkcji rolniczej.
Obserwowany wzrost temperatury i wilgotności powietrza wpływa na występowanie i rozwój w zasiewach pszenicy mączniaka prawdziwego zbóż i traw (Blumeria graminis f.sp. tritici). Choroba ta, występuje każdego roku, w różnym nasileniu, powodując straty w plonach sięgające 20-40%. Ze zmianami klimatu związana jest migracja mączniaka prawdziwego zbóż i traw w kierunku północnym, w strefę klimatu chłodniejszego i wilgotniejszego.
W przeciwdziałaniu niekorzystnych zmian klimatu na produkcję rolniczą ważną rolę odgrywa modelowanie matematyczne, które staje się kluczowym narzędziem stosowanym do prognozowania stabilnej produkcji roślinnej. Ponadto, ważnym kierunkiem badań obejmujących przeciwdziałanie negatywnym skutkom zmian klimatu na produkcję roślinną jest zrównoważone wykorzystanie zasobów genowych. Poszerzenie bazy genetycznej w dobie zmieniającego się klimatu jest istotnym aspektem dzisiejszej hodowli odpornościowej.
W niniejszej publikacji przedstawiono doniesienia dotyczące wpływu zmian klimatu na mączniaka prawdziwego zbóż i traw, prognozowanie zagrożeń przy wykorzystaniu modeli matematycznych, jak również podkreślono znaczenie zasobów genetycznych w przeciwdziałaniu negatywnym skutkom zmian klimatu.
Uric acid in atherosclerosis and cardiovascular diseases: innocent bystander or ruthless killer?
Authors: Cimmino Giovanni , Natale Francesco , Franzese Rosa , Morello Mariarosaria , Titolo Gisella , Mollo Noemi , Caso Valentina Maria , Golino Paolo , Cirillo Plinio
Published: June 2024

Medical attention to uric acid (UA) has been increasing in recent years, mainly because this molecule has been shown to be associated with increased cardiovascular risk, both in the general population and in the hypertensive patients. A growing body of clinical and experimental data supports this view and prompts reconsideration of the role of UA in the development of atherosclerosis and the genesis of cardiovascular disease. It is known that this substance, in certain plasma concentrations, induces increased oxidative stress, a chronic inflammatory state, and a whole series of other modifications that are potentially deleterious at the cardiovascular level leading to hypertension, atherosclerosis, atrial fibrillation (AF), and other metabolic changes such as diabetes, metabolic syndrome, non-alcoholic fatty liver disease and kidney failure. Despite this epidemiologic and mechanistic evidence, the current guidelines from international cardiology scientific societies do not give precise indications in this regard, and some of them only suggest UA evaluation as part of an initial screening of the hypertensive patient. The purpose of this review is to briefly describe the main clinical and epidemiological evidence supporting the role of hyperuricemia as a possible emerging cardiovascular risk factor and to analyze the potential pathophysiological mechanisms through which elevated UA levels may exert a detrimental effect on the cardiovascular system.
مدى رضا الزوار عن السياحة الزراعية بالمدينة المنورة
Authors: هليل العمري د. نهله , عبدالعزيز الجاسر د. لميعة
Published: June 2024

هدفت الدراسة إلى قياس رضا الزوار عن السياحة الزراعية بالمدينة المنورة، وذلك بهدف التعرف على الخصائص الديموغرافية للزوار ومدى رضاهم عن الزيارة والفروق الإحصائية بين أفراد العينة التي يمكن عزوها لمتغيرات (العمر – النوع – مكان الإقامة – عدد ساعات الزيارة). وقد بلغ عدد أفراد العينة 46 مشارك من زوار المزارع السياحية بالمدينة وهي مزرعة السهلة ومزرعة أرياف طيبة ومزرعة الأوسية. وللإجابة على تساؤلات الدراسة تم استخدام الأساليب الإحصائية مثل التكرارات والنسب المئوية لوصف الخصائص الديموغرافية للزوار والمتوسط الحسابي لمعرفة مدى رضا الزوار عن السياحة الزراعية بالمدينة المنورة واختبار (T-test) واختبار تحليل التباين الأحادي (ANOVA) لمعرفة الفروق ذات الدلالة الإحصائية بين أفراد عينة الدراسة في رضاهم عن السياحة الزراعية بالمدينة المنورة والتي تعزى للمتغيرات (العمر – النوع – مكان الإقامة – عدد ساعات الزيارة). بلغ المتوسط العام لدرجة رضا الزوار عن السياحة الزراعية بالمدينة المنورة هو (3.60) بدرجة رضا جيدة جداً وذلك بناء على قيمة المتوسط المرجح الذي تم تحديده. وقد كانت أقل الفقرات في تقدير رضا الزوار والتي حصلت على تقدير جيد هي (لباقة الموظفين وتوفر محلات الهدايا وكفاية دورات المياه وتوفر خدمة الإرشاد السياحي وتنوع الأنشطة والفعاليات و مناسبة الأسعار بالإضافة إلى توفر وسائل المواصلات ووجود مواقف سيارات كافية)، بينما أعلى الفقرات التي حصلت تقدير ممتاز هي (الترحيب بالزوار وتوفر الجلسات). وكذلك تبين إنه لا توجد فروق ذات دلالة إحصائية عند مستوى الدلالة (0.05) في رضا الزوار عن السياحة الزراعية بالمدينة المنورة والتي تعزى للمتغيرات التالية: (العمر – النوع – مكان الإقامة – عدد ساعات الزيارة). ومن أبرز التوصيات هي تأهيل الموظفين للإرشاد السياحي وأساليب التعامل مع الزوار، وإضافة أنشطة وفعاليات متنوعة يمارسها الزوار أثناء الزيارة مثل المشاركة في الحصاد والتخييم والسباحة والنزل الريفية وركوب الخيل، وإعداد متاجر متخصصة في الهدايا التذكارية المصنعة محلياً، بالإضافة إلى مراقبة الأسعار من قبل الجهات المعنية، توفير مواقف سيارات كافية وتوفير باصات نقل من وإلى الأماكن العامة
مستويات الراحة الفسيولوجية للإنسان في مدينة بني وليد
Authors: محمد احمد ساسي أ. حمد
Published: June 2024

تناولت هذه الدراسة مستويات الراحة الفسيولوجية للإنسان في مدينة بني وليد وهدفت هذه الدراسة إلى معرفة مستويات الراحة الفسيولوجية للإنسان في مدينة بني وليد كيف يؤثر المناخ على راحة الإنسان الفسيولوجية في المدينة , كما هدفت إلى معرفة الشهور المريحة وغير المريحة للإنسان في مدينة بني وليد , ولتحقيق هذه الأهداف تم استخدام المنهج الوصفي وكذلك المنهج الكمي وذلك باستخدام مؤشر الحرارة والرطوبةTHI )  ) أو ما يعرف بقرينة ثوم كما تم جمع البيانات المناخية اللازمة من مصادر مختلفة أهمها بيانات المركز الوطني للأرصاد الجوية في طرابلس , وقد توصلت هذه الدراسة إلى وجود اشهر مريحة واشهر غير مريحة للإنسان في مدينة بني وليد حيث أن أشهر مارس وأبريل ومايو وأكتوبر ونوفمبر هي اشهر مريحة للإنسان في مدينة بني وليد وان اشهر يناير وفبراير وديسمبر هي اشهر غير مريحة بسبب برودتها وكذلك اشهر يوليو وأغسطس وسبتمبر هي اشهر غير مريحة بسبب حرارتها أما شهر يونيو فمريح ل 10% من السكان , وتوصي الدراسة بحماية الأراضي الزراعية المحيطة بالمدينة
إشكاليات المصطلحات والمفاهيم الفلسفية (الأخلاق والإتيقا أنموذجـاً)
Authors: حسين إبراهيم الشريف د. إبراهيم , حسين إبراهيم الشريف د. إبراهيم
Published: June 2024

استعمال لفظ أخلاق وإتيقا يترادف لدى كثير من المفكرين والكُتاب، ومن دون تمييز يذكر بينهما إلا فيما ندر. فاللفظان أخلاق وإتيقا لهما جذران لغويان مختلفان، فبينما ينحدر لفظ (الأخلاق Morale ) من اللغة اللاتينية، فإن لفظ (إيتقا Ethique) متأت من اللغة  الإغريقية الذي يفيد العادات، التصرف في الحياة، قواعد السلوك .. الخ. فهل حقاً اللفظان مختلفان، وأن هناك لبس في الأذهان في الحكم عليهما بأنهما يؤديان إلى معنى واحد في مفاهيمنا ومصطلحاتنا القيمية في الفلسفة والعلم. هذا ما نحاول طرحه ضمن المفهوم الغربي للفلسفة العامة وتبريراتها في سياق حوار يقع على المستوى العقلاني والإنساني، وما جدوي اختلافهما وتأثيرهما على الفهم العام للفلسفة والقائمين عليها دراستاً وبحثاً وتخصصا.
دراسة للتعرف على مستوى الإتزان الانفعالي لدى طلبة قسم التربية البدنية والرياضية المرج / جامعة بنغازي
Authors: علي إبراهيم يوسف الرملي د. إبراهيم , محمد عبدالدائم عبدالحميد د. أيمن , محمد ضو إحميدة د. مجدي
Published: June 2024

دراسة للتعرف على مستوى الإتزان الانفعالي لدى طلبة قسم التربية البدنية والرياضية المرج/ جامعة بنغازي حيث يهدف البحث إلى للتعرف على مستوى الاتزان الانفعالي لدى طلبة قسم التربية البدنية والرياضية المرج/ جامعة بنغازي وللتعرف على الفروق في مستوى الاتزان الانفعالي بين طلاب النظام الفصلي للفصلين (الأول، الثامن) وقد استخدم الباحثون المنهج الوصفي بأسلوب المسحي لتحقيق أهداف البحث وكانت عينة مكونة من (80) طالباً في قسم التربية البدنية والرياضية بالمرج / جامعة بنغازي والتي تمثل ما يقارب (25٪) من مجتمع البحث الأصلي الذي بلغ (352) طالباً في فصل الخريف 2019/2020 وكانت أداة البحث استبيان من تأليف وتصميم (المسعودي، 2002) والمكون من (70) فقرة وكانت أهم الاستنتاجات - انخفاض مستوى الاتزان الانفعالي لدى عينة البحث - وجود تباين بسيط في ثبات الاتزان الانفعالي والذي لا يرتقي الى المعنوية بين مرحلتي البحث للفصلين (الاول، الثامن).
عهد الإسكندر الأكبر في مصر من دخوله إليها عام 332 ق.م وحتى وفاته عام 323 ق.م والأوضاع التي ترتبت عليها
Authors: إبراهيم حسين د. عُليه
Published: June 2024

كان لفتح الإسكندر لمصر عام 332 ق.م ومعاملته الطيبة للمصريين, ظاهره الرحمة وباطنه العذاب, كارثة كبرى في تاريخ مصر ومأساة فادحة, ذلك لأن الغزو إنما كان بدايةً لعصرٍ من الاحتلال الإغريقي والروماني عمّ المنطقة العربية كلها, وكان الإسكندر لبقاً إذ تظاهر بمظهر المخلّص لمصر من نيران الفرس, لأن المصريين أنفسهم كانوا يتطلعون إلى ذلك, حيث كانت مصر قبل مجيئ الإسكندر الأكبر إليها ترزح تحت الاحتلال الفارسي الذي اتخذ من يومه الأول نهجاً عدائياً تجاه ثقافة المصريين وعقائدهم, حيث سخر الفرس من أديانهم, فدنسوا المعابد وأبطلوا الشعائر الدينية, كما فرضوا دينهم على المصريين قصراً, ناهيك عن العلاقات السيئة والمتوترة على الدوام بين الإدارة الفارسية والمصريين, لذلك رأى المصريون في حملة الإسكندر الأكبر نوعاً من التحرير خاصةً بعدما أظهره الإسكندر من احترام لمعبوداتهم, وإدراكاً منه لأهمية مصر وموقعها الجغرافي, أمر بإنشاء مدينة ساحلية جديدة هي (الإسكندرية) التي أصبحت بعد فترة وجيزة واحدة من أهم مدن العالم التجارية, ومنارة علمية عظيمة يقصد مدارسها ومكتباتها طلبة العلم من كافة الأصقاع.
Navigating the complex terrain of hepatitis B virus reactivation in the era of Bruton tyrosine kinase inhibitors
Authors: Liu Wei-Nung , Dai Ming-Shen , Lin Felicia , Lin Gen-Min
Published: June 2024

In this editorial, we offer a summary of the risk associated with hepatitis B reactivation (HBVr) in the setting of both solid and hematologic malignancies treated with Bruton tyrosine kinase (BTK) inhibitors, with insights derived from current studies. Furthermore, we emphasize the critical need for a framework regarding robust risk evaluation in patients undergoing such treatments. This framework is essential for identifying those at increased risk of HBVr, enabling healthcare providers to implement proactive measures to prevent reactivation and ensure the safe administration of BTK inhibitor therapy.
Thymoquinone affects hypoxia-inducible factor-1α expression in pancreatic cancer cells via HSP90 and PI3K/AKT/mTOR pathways
Authors: Zhao Zhan-Xue , Li Shuai , Liu Lin-Xun
Published: June 2024

BACKGROUND

Pancreatic cancer (PC) is associated with some of the worst prognoses of all major cancers. Thymoquinone (TQ) has a long history in traditional medical practice and is known for its anti-cancer, anti-inflammatory, anti-fibrosis and antioxidant pharmacological activities. Recent studies on hypoxia-inducible factor-1α (HIF-1α) and PC have shown that HIF-1α affects the occurrence and development of PC in many aspects. In addition, TQ could inhibit the development of renal cancer by decreasing the expression of HIF-1α. Therefore, we speculate whether TQ affects HIF-1α expression in PC cells and explore the mechanism.

AIM

To elucidate the effect of TQ in PC cells and the regulatory mechanism of HIF-1α expression.

METHODS

Cell counting kit-8 assay, Transwell assay and flow cytometry were performed to detect the effects of TQ on the proliferative activity, migration and invasion ability and apoptosis of PANC-1 cells and normal pancreatic duct epithelial (hTERT-HPNE) cells. Quantitative real-time polymerase chain reaction and western blot assay were performed to detect the expression of HIF-1α mRNA and protein in PC cells. The effects of TQ on the HIF-1α protein initial expression pathway and ubiquitination degradation in PANC-1 cells were examined by western blot assay and co-immunoprecipitation.

RESULTS

TQ significantly inhibited proliferative activity, migration, and invasion ability and promoted apoptosis of PANC-1 cells; however, no significant effects on hTERT-HPNE cells were observed. TQ significantly reduced the mRNA and protein expression levels of HIF-1α in PANC-1, AsPC-1, and BxPC-3 cells. TQ significantly inhibited the expression of the HIF-1α initial expression pathway (PI3K/AKT/mTOR) related proteins, and promoted the ubiquitination degradation of the HIF-1α protein in PANC-1 cells. TQ had no effect on the hydroxylation and von Hippel Lindau protein mediated ubiquitination degradation of the HIF-1α protein but affected the stability of the HIF-1α protein by inhibiting the interaction between HIF-1α and HSP90, thus promoting its ubiquitination degradation.

CONCLUSION

The regulatory mechanism of TQ on HIF-1α protein expression in PC cells was mainly to promote the ubiquitination degradation of the HIF-1α protein by inhibiting the interaction between HIF-1α and HSP90; Secondly, TQ reduced the initial expression of HIF-1α protein by inhibiting the PI3K/AKT/mTOR pathway.
Perception and food consumption frequency due to the Covid-19 pandemic among University students in Trujillo City, Perú
Authors: Aquino Romero Yubis , Carrera Zegarra Niv Leandro , Montalván Tuesta Xiomara , Tirado Valverde Kiara , Montenegro Cruz Marilin , Guillén Sánchez Jhoseline Stayce , Rojas-Villacorta Walter
Published: June 2024

Introduction: The confinement due to COVID-19 significantly affected people's food consumption, especially university students who had to adapt to virtual education. Objective: To determine the perception and food consumption frequency due to the COVID-19 pandemic among Peruvian students from a private university in Trujillo City, Peru. Materials and method: The research design was non-experimental, descriptive, and cross- sectional. The non-probabilistic sample consisted of 169 students and the instrument used was a virtual survey (Cronbach's alpha = 0.846). Results: It is shown that there is a higher frequency of young people (n = 116) and adolescents (n = 45) who participated in the study, and that the average age was 22.15 ± 3.77 years. Likewise, the Frequency of Consumption dimension, it showed a higher frequency in the "Sometimes" scale, where it is related to whether it exceeded the number of meals per day (34.9%), eating out of control (38.5%), desires to eat unhealthy food (32.0%) and whether it influenced eating (30.8%). Similarly, it was shown that the majority of respondents consumed fruits (68.6%) and vegetables (58.0%) and considered water consumption essential (98.3%). On the other hand, there was a higher frequency regarding the consumption of ultra-processed foods (n = 95, 56.2%). Conclusion: The population of a private university made up mostly of young people and adolescents perceives that there was a change in their diet during the COVID-19 pandemic.