bluuebunny/crossref_metadata_2025 huggingface dataset:
Establecimiento del nicho en el planteamiento del problema: recursos de negación y posicionamiento del autor
Authors: Díaz Blanca Lourdes Ángela
Published: March 2023

El objetivo del artículo es analizar los pasos retóricos que configuran el establecimiento del nicho de investigación en el planteamiento del problema de trabajos de grado de Lingüística y los recursos de negación empleados por el autor para posicionarse en las fronteras del conocimiento. En este estudio exploratorio se obtuvieron seis pasos retóricos: señalamiento de un problema, indicación de ausencias o insuficiencias, cuestionamiento a otros estudios, formulación de preguntas de investigación, justificación del estudio y seguimiento de una tradición. Se emplean recursos de negación que enfatizan las aserciones e indican mayor nivel de certeza en el posicionamiento de los autores.
Structural Analysis of Kirthar Fold Belt, Lower Indus Basin, Balochistan, Pakistan; Implications from Compression and Inversion Tectonics
Authors: Khalid Adnan , Ahmad Sajjad , Ali Asghar , Rehman Gohar , Yaseen Muhammad
Published: March 2023

The current research work mainly focuses on tectonic evolution of the Central Kirthar Fold Belt. It also deals with the structural impact of the Late Cretaceous/Paleocene, Indian-Eurasian collision on the Central Kirthar Fold Belt which is situated in the western shear zone of Indian Plate. The Kirthar Fold Belt is different from the rest of western shear zone because it is mainly deformed by compressional tectonics which has created wide anticlines, narrow synclines and overturned folds as shown by geological mapping. It has been observed that thin-skinned deformation has played a major role in structural disharmony which is mainly seen in the Early Eocene Ghazij and Oligocene Nari formations. Seismic data shows thick-skinned deformation because the faults seem to penetrate deeper stratigraphic levels. Involvement of the basal decollement and the penetration of the interpreted faults to the level of basement rocks is also evident from the exposure of Jurassic/Cretaceous rocks at surface on the western part of the mapped area. Cross sections data shows that Kirthar Thrust Fault has a structural throw around 3-4 km in the Kirthar Folded Zone featuring deformational front while the seismic data and well data shows that this intensity decreases in the Kirthar Foredeep Zone towards east where the structural throw is about 2-3 km. Restoration of cross sections show an overall 17.3% shortening which shows that the area is under influence of compressional stresses.
Effect of Temperature on Germination, Radial Growth, and Sporulation of the New Isolates of Metarhizium anisopliae and their Virulence to Whitefly, Bemisia tabaci (Hemiptera: Aleyrodidae)
Authors: Sani Ibrahim , Jamian Syari , Ismail Siti Izera , Saad Norsazilawati , Abdullah Sumaiyah , Mohd Hata Erneeza , Jalinas Johari
Published: March 2023

Metarhizium anisopliae is a potential entomopathogenic fungi (EPF) to control insect pests in Malaysia, yet little is known about the temperature influence on its growth and efficacy. The average daily temperature in Malaysia is between 21 °C and 32 °C, with some parts of Cameron Highland in Peninsular Malaysia experiencing temperatures as low as 14 °C. Therefore, for effective field application, the most effective EPF isolates should be tolerant to the temperature of the country. Here we conducted a laboratory experiment to determine the effects of average daily temperatures in Malaysia (15, 20, 25, and 30 °C) on conidial germination, radial growth, and conidial density of seven new isolates of M. anisopliae. However, at 25 and 30°C, the three isolates (Ma-2, Ma-9, and Ma-15) produced the highest number of conidia and were therefore selected for virulence test against the second instar of whitefly, Bemisia tabaci. The percentage mortality of the three isolates ranged between 36.1% and 97.7% across different temperatures for 7 days post-treatment. The isolates Ma-15 caused the highest percentage mortality of 97.7% and the shortest LT50 and LT90 values (1.68 and 3.98 days, respectively), at 30 °C incubation temperature. This study confirms that the growth and virulence of Malaysian isolates of M. anisopliae are strongly influenced by temperature and could be used as promising candidates for biocontrol of B. tabaci on vegetables planted in a tropical climate such as that of low land and highland in Malaysia, although extensive field and semi-field bioassays, as well as the development of ideal formulation, are still required.
Electrocardiogram Analysis of Wistar Rats Induced by Hyperlipidemia using Wireless Mice Electrocardiogram (Wim ECG) in Coronary Heart Disease Study
Authors: Maulana Harfi , Ridwan Ahmad , Suprijanto Suprijanto , Shanty Rahayu Kusumawardani Shanty Rahayu Kusumawardani , Fitri Lulu Lusianti
Published: March 2023

Coronary heart disease (CHD) is a life-threatening disease caused by obstruction of the coronary arteries that interferes with blood flow known as atherosclerosis. Hyperlipidemia, a risk factor of atherosclerosis, is characterized by excessive concentrations of total cholesterol, LDL, and triglycerides with low concentrations of HDL. A high-fat diet (HFD) contributes to the progression of atherosclerosis, CHD, and other cardiovascular diseases. This study aims to measure electrocardiography (ECG) waves of hyperlipidemia-induced rats. Twenty rats were fed different diets for eight weeks, i.e., the control group (normal diet) and the HFD group (high-fat diet). Their ECG was recorded using a Wireless Mice Electrocardiogram (WIM ECG) for 5-10 min. After eight weeks, the HFD group showed a significantly higher lipid profile concentration (cholesterol: 179.03 mg/dL, triglyceride: 149.11 mg/dL, LDL: 123 mg/dL, HDL: 29.15 mg/dL) than the control. This hyperlipidemic condition causes a significant change in some characteristics of the ECG wave. At week 8, the characteristic ECG wave duration for the HFD groups was RR intervals (176.5 ms), QT intervals (123.5 ms), T waves (33.6 ms), P wave (27.4 ms), QRS interval (64.9 ms), ST-segment (23.7 ms), and heart rate (334 bpm). This study concludes that long-period HFD feeding in rats leads to hyperlipidemia and causes changes in the characteristics of ECG waves.
Arithmetic statistically convergent on neutrosophic normed spaces
Authors: GÖNÜL BİLGİN Nazmiye
Published: March 2023

This work is concerned with several important different types of convergence that will be described on neutrosophic normed spaces. In the study, arithmetic convergence was combined with different types of statistical convergence and then integrated into the structure of neutrophic spaces established through the membership function. For this purpose, in the neutrophic normed space, firstly, some important definitions that can be established with lacunary sequence, ideal structures and arithmetic convergent, arithmetic statistical convergence concepts are given, and then some relationships between convergent sequences in this sense are examined. Then, new convergence definitions were established by evaluating lambda sequences together with arithmetic convergence and statistical convergence with the help of Neutrophic normed space structure properties. Finally, with the help of the definitions of degree of convergence, the inclusion relationship between the two set is given.
FEATURES OF THE RECEPTIONS OF MARXISM IN CHINESE PHILOSOPHY
Authors:   Taras Shevchenko National University of Kyiv, Ukraine, Yarmolitska Nataliia
Published: March 2023

In the article are highlighted features of the receptions of marxism in chinese philosophy. Currently, the study of reception is one of the productive directions of the modern history of philosophy, because it allows you to gain knowledge about the philosophical culture and philosophical tradition of China, as well as to find out when the birth of marxism in chinese philosophy took place. The main goals the article is reconstruction a way of describing the emergence of marxism in chinese philosophical thought, reproduction of the theoretical model of the main stages of its development; to explanation the keys problems, to which the attention of chinese philosophers was directed, from the standpoint of soviet and modern researchers; a description of the main figures who laid the foundations for the birth of marxism in chinese philosophy. In the result of investigation, on the basis of theoretical and methodological guidelines and requirements of scientific analysis and theoretical reconstruction, the main post-soviet narratives of the genesis of marxist-leninist philosophy in china were systematized, as well as an assessment of their theoretical, methodological and ideological attributes.
Artificial intelligence in clinical physiology: How to improve learning agility
Authors: Shutov Dmitry V. , Sharova Dariya E. , Abuladze Liya R. , Drozdov Dmitrii V.
Published: March 2023

Clinical physiology involves a complete, comprehensive, multilateral study of the functions of both affected and healthy organs, which allows us to assess the compensatory capabilities of the body.
Artificial intelligence is increasingly being used in medicine, including in clinical physiology. This is facilitated by the increase in computing processing power, development of cloud services and datasets, and numerous scientific articles demonstrating the effectiveness and viability of such intelligent solutions.
Although the approach to medical dataset development is generally similar, there are a number of key features and significant differences in clinical physiology. Artificial intelligence systems in clinical physiology may be effectively trained and applied in practice by following the recommendations in this study.
The national standard of the Russian Federation GOST R 59921.9-2022, which has entered into force, is included in the set of standards Artificial Intelligence systems in clinical medicine and establishes additional requirements for data analysis algorithms and test methods of artificial intelligence systems used in the field of clinical physiology. A crucial feature of the created standard is its qualimetric type (i.e., it has a mandatory set of demonstration data).
Russia is one of the first countries to start developing quasi-metric standards worldwide, and 15 industry standards in the field of artificial intelligence (2 of them in medicine) will come into force this year.
Seismogenic Potential of the Subduction Zone in Northern Chile
Authors: Michel Sylvain , Jolivet Romain , Jara Jorge , Rollins Chris
Published: March 2023

The northern Chile region of the Nazca subduction zone ruptured in an Mw∼8.5–9.0 earthquake in 1877, which induced a tsunami. The various magnitude estimates of this event are based on the evaluation of historical records, seismic intensities, and/or tide gauge information; however, its actual along-strike extent is debated. Based on geodetic data, the previous studies have suggested that this region has the potential for an Mw 8.2–8.8 event. We re-evaluate the seismic potential of the region, accounting for the buildup rate of moment deficit along the megathrust, the earthquake magnitude–frequency distribution, and the physics of earthquakes. We combine an improved probabilistic estimate of moment deficit rate with results from dynamic models of the earthquake cycle, testing, in particular, the influence of a potential aseismic barrier near the city of Iquique, which may influence the extent and magnitude of large events in this region. We find that Mw 8.8 is the most probable maximum magnitude earthquake in the region, and that the potential barrier likely has a limited impact considering uncertainties. We discuss the effect of the moment deficit rate on the fault, the b-value, and the importance of postseismic processes on our results.
Subclassification of advanced-stage hepatocellular carcinoma with macrovascular invasion: combined transarterial chemoembolization and radiotherapy as an alternative first-line treatment
Authors: Jin Sujin , Choi Won-Mook , Shim Ju Hyun , Lee Danbi , Kim Kang Mo , Lim Young-Suk , Lee Han Chu , Jung Jinhong , Yoon Sang Min , Choi Jonggi
Published: March 2023

Background/Aim: The Barcelona Clinic Liver Cancer (BCLC) guidelines recommend systemic therapy as the only first-line treatment for patients with BCLC stage C hepatocellular carcinoma (HCC) despite its heterogeneity of disease extent. We aimed to identify patients who might benefit from combined transarterial chemoembolization (TACE) and radiation therapy (RT) by subclassifying BCLC stage C.Methods: A total of 1,419 treatment-naïve BCLC stage C patients with macrovascular invasion (MVI) who were treated with combined TACE and RT (n=1,115) or systemic treatment (n=304) were analyzed. The primary outcome was overall survival (OS). Factors associated with OS were identified and assigned points by the Cox model. The patients were subclassified into three groups based on these points.Results: The mean age was 55.4 years, and 87.8% were male. The median OS was 8.3 months. Multivariate analysis revealed a significant association of Child-Pugh B, infiltrative-type tumor or tumor size ≥10 cm, main or bilateral portal vein invasion, and extrahepatic metastasis with poor OS. The sub-classification was categorized into low (point ≤1), intermediate (point=2), and high (point ≥3) risks based on the sum of points (range, 0–4). The OS in the low, intermediate, and high-risk groups was 22.6, 8.2, and 3.8 months, respectively. In the low and intermediate-risk groups, patients treated with combined TACE and RT exhibited significantly longer OS (24.2 and 9.5 months, respectively) than those who received systemic treatment (6.4 and 5.1 months, respectively; P<0.0001).Conclusions: Combined TACE and RT may be considered as a first-line treatment option for HCC patients with MVI when classified into low- and intermediate-risk groups.
An Investigation into The Frequency and Causes of Fleas in Goat Farms
Authors: TAŞKIN Turgay , KANDEMİR Çağrı , KOŞUM Nedim , UN Cemal , CAN Hüseyin , ERKUNT ALAK Sedef , KÖSEOĞLU Ahmet
Published: March 2023

The objectives of the study are to determine the flea density in goat farms in the Bornova district of the province of Izmir, investigate the reasons, and develop remedies. This study is a situation determination to determine the flea problem in extensive goat farms. The research sample, which was carefully selected from the agricultural and livestock records kept by the Bornova District Directorate, consisted of 39 goat farms. According to research, 84.61% of sheep and goat farms experience flea problems, and 94.87% of those farms lose animals as a result of flea infestations. 33.33% of the body colours of animals with fleas are black. The most frequently infested animals by fleas were goats (28.21%) and young animals (33.33%). The main symptoms of a flea infestation are itching and hair loss (17.95% and 20.51%). Removing manure from the barn was the most widely used flea management technique (38.46%), followed by using pesticides (17.95%). Cats or dogs were reported to have flea issues in 89.74% of the farms. As a result, if flock management activities including hygiene and sanitation, animal welfare, and health-protection techniques are done well, the damage caused by ectoparasites will be reduced. To prevent potential financial losses in the flock, it is recommended to emphasise to goat producers the importance of flea infestations and to apply appropriate flea control methods.
A Pre-clinical Study of Jeerakadi Lepa against Indian Red Scorpion Venom Poisoning
Authors: Kulkarni Pallavi Satyajit , Gramopaghye Narayan Gajanan , Kulkarni Satyajit Pandurang
Published: March 2023

Scorpion stings are very common in India, especially in the Konkan region of Maharashtra state. Scorpion stings show various signs and symptoms. A preclinical study to validate the efficacy of an Ayurvedic preparation called Jeerakadi Lepa was done in Swiss albino mice. A total of 18 Swiss albino mice (n = 18) were divided into 3 groups: the control group (n = 6), the standard group (n = 6) and the experimental group (n = 6). Only Indian red scorpion venom was administered by the SC route in the control group. In contrast, the venom was administered by SC in the standard group, followed by an oral tablet. Prazosin, and in the experimental group, the venom was administered by SC route, followed by local Jeerakadi Lepa. Kruskal-Wallis’s test was applied at a 95% confidence interval to assess various toxicity parameters like lacrimation, salivation, etc. The P-value was 0.04433 in toxicity symptoms (P < 0.05), but it was 0.3366 (P > 0.05) in the number of deaths of Swiss albino mice in the above groups. It was concluded that Jeerakadi Lepa effectively eliminated all the signs and symptoms of toxicity due to scorpion venom in Swiss albino mice. Still, it should not be used independently among humans.
Development and Validation of HPLC and UV Spectrophotometric Method for the Quantification of Cinnamaldehyde in Cinnamon Bark Extract
Authors: Dhillon Anjali , Sardana Satish , Thakkar Arti R.
Published: March 2023

Cinnamaldehyde is the prime constituent of cinnamon bark and cassia oil. It is used as a flavoring agent. Numerous methods described the determination of cinnamaldehyde based on volumetric analysis, ultraviolet spectrometry, fluorimetry, thin layer chromatography, liquid chromatography and gas chromatography. The natural absorbance of cinnamaldehyde is at 286 nm which is used as a base for its determination through spectrophotometry or a suitable derivatizing reagent is used for its estimation. Most of these methods were simultaneous estimation methods and if non-simultaneous than not sensitive. Therefore, in the present study, sensitive HPLC and UV Spectrophotometric procedures have been established for the estimation of cinnamaldehyde in Cinnamon extract. The retention time of cinnamaldehyde was 7.21 minutes and absorption maxima come out to be 282 nm. 2.55 ± 0.003 mg/ml quantity of cinnamaldehyde was present in the cinnamon extract which is detected by UV Spectrophotometric method. Accuracy information appeared in the range that gives decent recovery figures for both processes. Sensitivity data furnished LOD 0.062 μg/ml and LOQ 0.19 μg/ml for HPLC and LOD 0.104 μg/ml and LOQ 0.312 μg/ml for UV Spectrophotometric method. The developed methods were found to be rugged and robust. The repeatability, Inter-day,and Intra-day precision of cinnamaldehyde provided RSD below 2% presenting the planned process to be extremely specific. Various factors to validate HPLC and UV Spectrophotometric methods of cinnamaldehyde were estimated and both methods show no significant difference. Developed procedures were statistically checked as per ICH guidelines.
Neuroprotective Potential of Solanum giganteum Leaves Extracts against Neurotoxin Agents and Oxidative DNA Damage in Rodents
Authors: Shende Vikas Suresh , Kakadiya Jagdish Labhubhai
Published: March 2023

Other species of Solanum are evaluated as neuroprotective and have conventionally been applied for the management of CNS disorders; on the other hand, investigational data to support this practice is lacking. Therefore, we aimed to assess the effect of Solanum giganteum leaves extracts aligned with Aluminium chloride-induced memory loss of Alzheimer’s Disease (AD) type within the rats. The work was considered to persuade dementia by chronic administration of aluminium chloride by a dose of 175 mg/kg, p.o. designed for 28 days in rats and rats are separated keen on seven groups, i.e. normal, negative control, standard groups as well as four groups of Solanum giganteum Jacq. (chloroform extract (SGC100 and 200 mg/kg) and alcoholic extract (SGA 250 and 500 mg/kg) p.o.), whereas these groups were treated and examined till the 28th day of an investigational trial. The research’s behavioral, neural, and biochemical characteristics were set up during or after it. DNA fragmentation and histological changes in the brain were also noted. Aluminium chloride on a dose of 175 mg/kg, p. o. had extensively persuaded dementia and Solanum giganteum Jacq. leaves chloroform extract 200 mg/kg p.o., overcomes therapeutic outcome against Aluminium chloride persuaded dementia of AD category in rats. Solanum giganteum Jacq. of chloroform extract makes use of neuroprotective action against AlCl3-induced behavioral considerations such as cognitive deficit and locomotor destruction. Further, Saolnum giganteum Jacq. of chloroform extract was also able to cure oxidative stress and neuroinflammation in the hippocampus and cortical areas, reversing the biochemical abnormalities caused by aluminum.
Development and Validation of HPTLC Method for Simultaneous Estimation of Piperine and Scopoletin in Ajmodadi churna
Authors: Dodiya Tanvi , Somavanshi Nisha , Prajapati Disha
Published: March 2023

In this recent study, several trials were made to develop a HPTLC method for quantification of scopoletin and piperine in the Ajmodadi formulation. HPTLC was done on pre-coated silica gel 60 F254 plates with a mobile phase of toluene:ethyl acetate:methanol:formic acid (3.9:3.9:0.3:1.7 v/v/v/v). The retardation factors for scopoletin 0.75 and for piperine was 0.86 and found a good and defined resolution peak. Densitometer analysis of scopoletin and piperine was carried out at 335 wavelength (nm). The developed method was validated as reported in ICH guidelines (Q2R1). A linearity study shows that scopoletin and piperine was linear, and the recovery studies revealed a recovery in between 98-102 % as per guideline. This method was established to be rapid, delicate, accurate and specific, thus, these methods may be used in the quantification of the drug in any polyherbal formulation.
The Electro-Spun Sublingual Film Containing Curcumin Micelles
Authors: Prajapati Bijal , Rede Pankita , Patel Chelsi , Pujari Rahul , Dharamsi Abhay
Published: March 2023

Hydrophilic polymers D-tocopheryl polyethylene glycol succinate (TPGS-1000) and Poloxamer-188 were combined for the formulation of a sublingual film that aids in improving the oral bioavailability of the drug curcumin, which is not very soluble. For the formulation of micelles, the thin-film hydration technique was used and then electro-spun into a sublingual film that contained 13 % w/v PVP. Following that, prepared micelles and films were assessed and evaluated (particle size, PDI, zeta potential, %EE, pH studies, disintegration time, and in vitro drug release). According to the findings, the average particle size of the blended micelles was 230.2 nm. The ideal formulation of mixed micelles had a mean zeta potential and PDI of 20.73 mV and 0.258±0.038, respectively. Additionally, an entrapment efficiency of 82% was reached. In an aqueous medium, the film disintegrated in 40±10 seconds. Micelles were incorporated into the film without losing their integrity. Importantly, as compared to a pure drug, the films with micelles put on them showed improved bioavailability, high permeability and rapid absorption of the curcumin. Compared to the pure drug, the bioavailability of the films was increased by around 2.18 times due to the presence of mixed micelles loaded with curcumin. The results also showed that micelles-loaded sublingual films performed well in vitro for bioavailability improvement. In the end, it was found that films containing a mixture of poloxamer-188 and TPGS-1000 micelles would function effectively as carriers to boost curcumin’s bioavailability.
Ethnobotany and Antimicrobial Activity of Traditional Plant -Holotelea integrifolia
Authors: Chakraborthy Gunosindhu , Mandal Snigdha Das , Jani Rupal K.
Published: March 2023

Holoptelea integrifolia (Ulmaceae) is a diversely used in Traditional Systems of medicine for healing aliments. The plant is preferred in the treatment and curing diseases like leprosy, inflammation, rickets, leucoderma, scabies, rheumatism, eczema, malaria and many more. The plants exhibits various pharmacological activities like antimicrobial, nociceptive, antiaging ,inflammation, anthelmintic, antidiabetic, adaptogenic, anticancer, wound healing, hepatoprotective, and hypolipidemic. The study on moprphological and microscopical was carried out on this plant as per the standards laid down by who to find the genuinity of the species. Physical constant values involving moisture content, ash and extractives as well as qualitative and quantitative estimation of various phytochemical have been studied. The presence of Saponins, Tannins, Terpenoids, Steroid, Flavonoids, and some other chemical constituents were recorded followed by antimicrobial activity of the plant against Gram Positive and Gram Negative Bacteria. Looking forward with the potential aspects of the plant used in Traditional system standardization parameters were to be considered for its validation and authentication.
Structural Elucidation of Anti-Pseudomonas Component from Eucalyptus Tereticornis
Authors: S. Badrunissa  , Vinitha Ramanath Pai
Published: March 2023

Eucalyptus species is a well-known medicinal plant from ancient times with diverse biological functions, antimicrobial activity being one of them. This study attempts to isolate a secondary metabolite with antibacterial properties from ethanol extracts of Eucalyptus tereticornis leaf by antibacterial - against Pseudomonas aeruginosa - activity-guided procedure. Ethanol extract of the leaf powder was obtained by soxhlation and subjected to liquid-liquid extraction with organic solvents – ethyl acetate, n-hexane, n-butane, and chloroform. The active n-hexane and chloroform extracts were purified by column chromatography, and the components of the active eluant fraction were separated by Thin-layer chromatography (TLC). The purity of the antibacterial compound was checked by high performance liquid chromatography (HPLC), the molecular weight determined by Liquid chromatography-mass spectroscopy (LC-MS) and the structure elucidated and identified by nuclear magnetic resonance (NMR) and by Fourier transform infrared spectrometer (FTIR). TLC of n-hexane extract of liquid-liquid extraction showed a single spot with antibacterial activity. A single major peak was observed on HPLC, and LC-MS revealed that the compound is a formylated phloroglucinol component (FPC) with a molecular weight of 471.3. The NMR and FTIR analysis identified that the isolated compound is Macrocarpal A. This study reveals that the isolated relatively pure anti-Pseudomonas compound from the leaf extracts of E. tereticornis is Macrocarpal A, a flavanoid from FPC.
An Overview of the Phytochemical and Pharmacological Profile of the Spurred Mangrove Ceriops tagal (Perr.) C. B. Rob
Authors: Manohar Sonal M. , Yadav Uttam M. , Kulkarnii Charuu P. , Patil R. C.
Published: March 2023

Plant-based natural compounds have played a significant role in developing a variety of clinically useful therapeutic agents. Mangroves are special salt-tolerant plant communities which are known to produce a range of natural products with unique pharmacological activities. An attempt has been made to review such properties in the mangrove plant Ceriops tagal (Perr.) C. B. Rob. belonging to the Rhizophoraceae family. This species is widely spread across the coastal lines of African, Asian and Australian continents and is also commonly found in India. Traditional healers have been using this plant and its extracts to treat ailments such as ulcers, diabetes and malaria. The plant is a rich source of phytochemicals such as tannins, flavonoids, terpenes, terpenoids, phytosterols and many more novel metabolites which have conferred remarkable pharmacological activities. Reports of antibacterial, antiviral, antioxidant, antifeedant, antifouling and anticancer activities from different parts of this plant highlight its importance as a natural remedy and the need to perform more investigations to discover novel bioactive compounds to further exploit its therapeutic potential.
In vitro Evaluation of Antibiofilm Activity of Methanolic Leaf Extract of Azadirachta indica on Cariogenic Streptococcus mutans
Authors: Dinesh Deepesh , Imran Khalid , Vijayaraghavalu Sivakumar , Saifulla Khan M. , Nikesh V. V.
Published: March 2023

Dental caries is a biofilm-dependent disease, and Streptococcus mutans is the primary etiological agent involved in the initiation of the disease. The extensive use of a limited range of antimicrobial drugs in dentistry has led to the development of drug-resistant bacteria. There is an increasing need to find new alternatives against drug-resistant bacteria. Globally, there is a continuous effort towards identifying natural anti-caries agents for the prevention and better management of caries. The objective of the present study was to evaluate the antibiofilm potential of Azadirachta indica leaf methanolic (ALM) extract against S. mutans biofilm. The study employed a standard reference strain of S. mutans MTCC 497, for in vitro standardisation of biofilm by microtiter plate assay. The antibiofilm activity of the ALM extract was evaluated against the S. mutans strain, and the same was confirmed by light and scanning electron microscopy (SEM). The in vitro biofilm standardisation results demonstrated that 50 µl/ml of S. mutans inoculum concentration exhibited a much superior biofilm formation than the other concentrations employed. Light microscopy and SEM images revealed that ALM extract at 100 mg/ml concentration significantly inhibited the S. mutans biofilm. To conclude, the study reports that the A. indica leaf extract is a potential source to inhibit the S. mutans biofilm. Further studies are warranted to identify the phytochemicals responsible for the antibiofilm activity of ALM extract against S. mutans biofilm that aid in the design of natural anti-caries products.
NATIONAL-STATE IDENTITY: METHODOLOGICAL AND HISTORICAL ASPECTS
Authors: Birinci Ebru , Zvereva Maria S. , Kapitsyn Vladimir M. , Karateev Artyom Yu.  , Pashin Mikhail  M. , Sergazin Yerbolat  F. , Talskaya Olga D. , Shcheglovitov Alexey E.
Published: March 2023

Aim. To introduce the scientific community to the research results presented at the international conference “National Identity and Patriotism in States in International Crises” (October 28, 2022) and the round table with international participation “National Identity, patriotism and Historical Memory” (December 23, 2022), organized by the Department of Political Sciences of the Institute of Scientific Information on Social Sciences of the Russian Academy of Sciences, Faculty of Political Science of Moscow State University named after M.V. Lomonosov with the support of the electronic online publication “Bulletin of Moscow Region State University”.

Methodology. The article presents data on the problems of uniting (“consolidating”) national identity and patriotism, including methodological problems of “political cyclism”,“return” cycles, agent modeling, ideological and semantic “counter-discourse”. The authors are researchers of ISISS RAS, Institute of Sociology of the RAS, Lomonosov Moscow State University, L. N. Gumilyov Eurasian National University (Republic of Kazakhstan).

Results. Based on the materials of theoretical and methodological, historical and applied research, the article highlights the spectrum of national identity and patriotism formation problems, the ethics of service history, the informational influence of foreign and inner destructive forces. The paper also considers the problems of cyclical changes in national identity, information and communication and cognitive aspects of identity, discourses and “counter-discourses” on social values, tasks of countering manipulative technologies with regard to the complexity of the ethno-national composition of society, the specifics of identification processes and public consciousness in Russia, Israel, Kazakhstan, Brazil.

Research implications. The published materials have theoretical, methodological and applied significance for the research of the national-state identity and the introduction of scientific results into the mechanisms of ideological and political confrontation of constructive and deconstructive forces, which is important in the education of patriotism, maintaining optimism and faith in the possibility of positive development in a tough struggle for identity. The conclusions and recommendations of the researchers can contribute to solving urgent political and educational tasks, improving the effectiveness of mechanisms that positively affect society consolidation, maintaining the ethics of “service”.
Формирование духовно-нравственных ценностей у детей на музыкальных занятиях
Authors: Солодова Т.Н.
Published: March 2023

Музыкальное воспитание имеет большое значение для формирования духовного развития личности ребѐнка. Важно формировать у детей не только общие представления о музыке, но и использовать потенциал музыкального искусства, обладающего большими воспитательными возможностями, что в итоге способствует развитию внутреннего мира ребѐнка. Музыкальное образование углубляет духовно-нравственные качества ребѐнка, влияет на воспитание чувства любви к Родине, родной природе, уважения к старшим, дружбы и товарищества.
Перспективы развития алгоритмов машинного обучения для распознавания CAPTCHA
Authors: Тимофеев Г.О. , Рощин А.Б.
Published: March 2023

CAPTCHA – это совокупность тестов, позволяющих отличить человека от автоматизированных программ. В данной статье мы проводим анализ различных подходов к распознаванию изображений CAPTCHA различного вида, выявляем их преимущества и недостатки и возможности для дальнейшего применения в области информационной безопасности
Эпидемиологические аспекты острых и хронических ЛОР-заболеваний у детей
Authors: Заидов Э.Я.
Published: March 2023

Основная масса обследованных детей была в возрасте 4—7 лет (40,0%) и 8—14 лет (60,0%) за 2015—2019 гг. Экспертный анализ структуры и уровня распространенности воспалительных заболеваний глотки и гортани показал, что наибольший удельный вес занимали острый гнойный воспалительный процесс, локализующийся в околоминдальной клетчатке (паратонзиллярный абсцесс) составляла 55,3±4,90%, и хроническое воспалительное поражение небных миндалин (хронический тонзиллит). Наибольшая распространенность ЛОР - патологии по обращаемости детского населения наблюдается в 2017 году. В структуре ЛОР-патологии ведущее место принадлежит заболеваниям носа и околоносовых пазух. До 2017 года был увеличен уровень распространенности острых и хронических риносинусопатий, а также хронического тонзиллита.
Связь эмоционального интеллекта с индивидуально-психологическими характеристиками личности
Authors: Малахова А.К.
Published: March 2023

В статье раскрывается понятие эмоционального интеллекта. Рассматривается взаимосвязь эмоционального интеллекта с индивидуально-психологическими характеристиками личности. Выявлены психологические особенности людей с разным уровень эмоционального интеллекта. Проведено исследование и даны рекомендации по его результатам.
Теория и практика лидерства в организации
Authors: Довлетмурзаева М.А. , Идигова Л.М.
Published: March 2023

В статье исследованы основные процессы становления индивида лидером, а также исследования и наблюдения таких известных личностей как Томас Карлейль, Габриэль Тард, Фридрих Ницше, Хосе Ортега-и-Гассет и др. Авторами анализируются множество факторов и характеристик, предложенных различными известными личностями, делающих человека эффективным руководителем. В статье сделан вывод о том, что лидеры всех видов организаций для осуществления своих полномочий на продолжительное время обязаны уметь гибко реагировать на изменения внешней и внутренней среды и правильно подбирать тип поведения на их основе.
Обзор стандартов по стадиям и этапам жизненного цикла сложной технической системы
Authors: Зайцев Д.А.
Published: March 2023

Задачи управления данными о сложной технической системе (СТС) и управления работами по созданию СТС являются взаимосвязанными и должны базироваться на единых информационных ресурсах. При этом важное место занимает построение системы управления проектом, основная задача которой состоит в координации действий исполнителей проекта, обеспечении согласованного планирования и контроля работ, предоставлении необходимой информации о ходе выполнения проекта.
Как продлить жизнь своему компьютеру?
Authors: Кумыкова Б.З. , Погиблова И.А. , Ермолаева В.В.
Published: March 2023

В этой статье мы поговорим о, казалось бы, банальных, но очень важных и эффективных способах продления срока службы вашего персонального компьютера
Признак Лобачевского сходимости числовых рядов
Authors: Болотаев В.Г.
Published: March 2023

На сегодняшний день раздел математического анализа, посвященный числовым рядам не потерял свою актуальность. Их широкое применение обусловлено точностью решений конкретных практических задач. Даже если некоторые тонкие понятия математического анализа появились вне связи с теорией рядов, они немедленно применялись к рядам, которые служили как бы инструментом для испытания значимости этих понятий. По сей день это положение не изменилось.
Особенности организации обучения в малокомплектной школе
Authors: Бабич И.О. , Клементьева И.С. , Маслова Т.А.
Published: March 2023

В статье раскрывается понятие малокомплектной школы, рассматриваются особенности организации обучения в малокомплектной школе. Представлены результаты исследования отношения будущих учителей к заявленной проблематике. Раскрывается роль самостоятельной деятельности, от продуктивности которой зависит продуктивность всего учебного процесса в школе. Определены особенности урока в классе с малочисленной наполняемостью. Рассмотрено правильное составление расписания уроков. Определена структура урока в малокомплектной школе.
Использование Google - сервисов как способ формирования исследовательских компетенций студентов
Authors: Гочияева М.Д. , Джанкезов А.С.
Published: March 2023

В данной статье анализируются возможности интернет сервисов Google для организации образовательного процесса как способ формирования исследовательских компетенций у бакалавров.
Ритмизация как мнемотехнический приѐм при формировании лексических навыков на занятиях по иностранному языку в неязыковом вузе
Authors: Досковская М.С.
Published: March 2023

В статье рассматривается собственный опыт автора по использованию вспомогательного мнемотехнического приѐма ритмизации для формирования лексических навыков на занятиях по иностранному языку в неязыковом (техническом) университете. Описывается учебный эксперимент, в задачи которого входило собственно формирование лексических навыков у студентов, а также проверка гипотезы о том, что использование ритмизации повышает эффективность обучения лексике. Сравнение результатов, полученных в экспериментальной и контрольной группах, гипотезу доказывает. Использование ритмизации на занятиях иностранному языку в неязыковом вузе способно повысить мотивацию студентов к изучению непрофильной для них дисциплины, делая процесс обучения более простым и увлекательным.
Цифровая трансформация процесса обучения иностранному языку в вузе
Authors: Морохова О.А.
Published: March 2023

Статья посвящена изучению дидактического потенциала цифровых электронных образовательных ресурсов на примере дисциплины «Иностранный (английский) язык». Автор статьи приходит к выводу, что цифровой трансформации процесса обучения английскому языку в неязыковом вузе способствует разработка нового дидактического аппарата дисциплины, который включает электронный курс на базе электронной информационной образовательно среды Moodle, использование текстовых редакторов для создания готового учебного продукта и использование открытых ресурсов сети Интернет для коммуникации и работы с информацией.
DEFINITION ON COLOR OF A LYSINE AFTER IT ELECTROFORETIC`S BRANCHES FROM A MIX OF α - AMINO ACIDS
Authors:   Saratov State University, Selifonova E. I. , Kosyreva I. V. ,   Saratov State University, Chernova R. K. ,   Saratov State University
Published: March 2023

Conditions selective electroforetic`s allocation of lysine from a mix of amino acids and its definition on color by visualization by a ningidrin are found. Products of interaction of lysine with ningidrin in the water environment and on a cellulose matrix are investigated. The example definition on color of a lysine after electroforetic`s branches is resulted.
Finite-Set Model Predictive Direct Power Control for DFIG with Reduced Number of Voltage Vectors
Authors: Guedes Felipe S. , Rocha Nady , Maciel Alvaro M. , Sguarezi Filho Alfeu J.
Published: March 2023

This paper proposes a Simplified Finite-Set Model Predictive Power Controller (MPPC) to improve the performance of the Doubly-Fed Induction Generator (DFIG). The MPPC is implemented to regulate the stator active and reactive powers of DFIG, minimizing the error between them and their references, with an optimized null vector selection and a reduced number of active vectors, to decrease the computational burden. This reduction is applied in a two-level converter, reducing the test to 4 or 2 active vectors. Simulations and laboratory experiments were performed, showing results for a 0.56 kW DFIG. Finally, it was verified that the proposed system can maintain the stator powers at a reference.
A High Step-Up Isolated DC-DC Converter Based on Cascaded Greinacher Voltage Multiplier
Authors: Andres Bernardo , Romitti Leonardo , Andrade António M. S. S. , Roggia Leandro , Schuch Luciano
Published: March 2023

High step-up converters are required and used in photovoltaic applications, due to low voltage of photovoltaic modules. In this paper, an isolated dc-dc high step-up SEPIC with a Greinacher voltage quadrupler cell is proposed. It has the advantage of continuous input current, high efficiency, high voltage gain, isolation and demands a single switch, being suitable for low power grid-tie photovoltaic systems. The derivation of converter, the operating principles and steady-state analysis are presented, including the detailed analysis of resonant stage, where the value of primary side capacitor is taken into account. Besides that, effects of transformer winding capacitances on converter operation are investigated. Experimental results on a 37.4/400 V, 50 kHz and 200 W prototype are presented to validate the proposed topology and concept, where the maximum efficiency obtained is 97.75%.
Do anxiety levels and attitudes towards COVID-19 vaccines among healthcare workers change after COVID-19 vaccination?
Authors: BALABAN Hasan , DEMİRDAĞ ÇEVİKKAN Meltem , TANYERİ KAYAHAN Selin
Published: March 2023

Objectives: The COVID-19 pandemic has significant effects on the mental health of societies and individuals worldwide while especially for healthcare workers these effects pose a higher risk due to occupational exposure. COVID-19 vaccines have been a turning point in the pandemic, however concepts as vaccine hesitancy and anti-vaccination have come into question again. This study aimed to comparatively evaluate the attitudes of healthcare professionals towards the COVID-19 vaccines, their pandemic-related anxiety and phobia levels before and after vaccination.
Methods: In this cross-sectional study, the anxiety levels and attitudes towards COVID-19 vaccines of healthcare professionals working in a state hospital were evaluated by administrating Coronavirus Anxiety Scale (CAS), Coronavirus-19 Phobia Scale (CP19-S), and Attitudes Towards COVID-19 Vaccine Scale (ATV-COVID-19) to the participants both in the pre-vaccine (n = 154) and post-vaccine (n = 81) periods. All these scales were previously validates in Turkish population. 44.8% (n = 69) of pre-vaccine sample and 45.7% (n = 37) of post-vaccine sample were female and all participants were Turkish. Participants were questioned about COVID-19 symptoms during each application and kept in touch in terms of side effects.
Results: One hundres fifty-four pre-vaccine and 81 post-vaccine health workers were included in the study. After the vaccination scores of CAS and CP19-S decreased significantly compared to the pre-vaccine period (p < 0.001 and p = 0.005, respectively); while ATV-COVID-19 scores significantly increased (p < 0.001). Participants did not report significant adverse events in the post-vaccine period.
Conclusions: The results of the study in the form of a decrease in anxiety and fear levels and an increase in positive attitudes towards the vaccine after vaccination suggest that vaccination may have a positive effect on the mental health of healthcare workers.
Associating craniofacial morphometry determined by photo analysis with somatotype in healthy young individuals
Authors: SEÇGİN Yusuf , TOY Şeyma , ŞENOL Deniz , ÖNER Zülal
Published: March 2023

Objectives: Evaluation of the relationship between craniofacial parameters and somatotype provides important contributions to specialist physicians and anatomists in determining diseases and obtaining objective results of anthropometric measurements. The study was designed in line with this hypothesis and the aim was to find out how this relationship changed in healthy individuals.
Methods: The study was conducted by examining 191 healthy individuals between the ages of 18 and 30. The individuals’ faces were photographed from a distance of 1 meter and craniofacial parameters were measured in Image J program. Somatotype analysis was conducted by using Heath-Carter somatotype method.
Results: As a result of our study, the individuals were found to be grouped in four classes according to Heath-Carter somatotype method: (1) mesomorph endomorph, (2) endomorph ectomorph, (3) endomorph mesomorph and (4) central. Significant correlation was found between the second and first somatotype groups in terms of total nasal length, while significant correlation was found between second and first/second and third/fourth and third/first and third somatotype groups in terms of body mass index (BMI) parameter (p < 0.05). Craniofacial parameters were also evaluated and a very high correlation was found between total facial height and mandibular height, while there was a high correlation between total facial height and the other 16 parameters.
Conclusions: As a result of our study, a relationship was found between somatotype groups and craniofacial parameters, within craniofacial parameters, and between somatotype and BMI. We believe that this relationship will guide morphological studies in basic medical sciences and surgical interventions in clinical sciences.
Covered with Writing... – Products on a Paper Base From the Archaeological Research at the Former Gestapo Headquarters in Anstadt Avenue in Łódź
Authors: Majorek Magdalena , Latocha Sebastian , Podolska-Rutkowska Irena , Olczyk Anna , Sidorczuk Ida
Published: March 2023

During the archaeological research conducted in 2019 under the project “The Former Headquarters of the Gestapo and the Communist Provincial Office of Public Security in Anstadt Avenue in Łódź. Interdisciplinary Site Research” under the supervision of Dr Olgierd Ławrynowicz, an object filled with products on a paper base and bookbinding materials was found in one of the excavations. This paper attempts to clarify the chronology of paper products and to identify their type (typescripts, prints of monetary value, books, bookbinding materials, arrangement drawings, other paper products) and the material used. The visible content was identified using basic research methods and digital photographic documentation of it was made to preserve it.