bluuebunny/crossref_metadata_2025 huggingface dataset:
Exploration vs. Exploitation: How Innovation Strategies Impact Firm Performance and Competitive Advantage
Authors: Ioniţă Cătălin Gabriel
Published: August 2022

In today’s economy, companies face the challenge of turbulent environments, which are characterized by rapid change, uncertainty, and unpredictability. Thus, for companies, these environments can be a double-edged sword because they can be responsible for rapid development opportunities and threats that can lead to organizational obsolesce. Businesses can lose their competitive advantage rapidly if they do not adapt to environmental changes, therefore, companies need to reinvent themselves by either exploiting available capacity or exploring new capabilities.

Innovative activities are beneficial for improving organizational vitality, but it is not clear how can be designed an effective innovation strategy and a system, that can respond to environmental changes both externally and internally. Ambidextrous innovation can be a relevant solution to this problem because it gives companies the opportunity to counteract the loss of competitive advantage by using a mix of innovative exploratory strategy and innovative exploitative strategy. Nowadays, ambidextrous innovation theory has been widely adopted by researchers to explain how is formed the mechanism of organizational performance and competitive advantage. According to researchers, this can be achieved by efficiently combining available, tangible, and intangible resources in the production and marketing of goods and services.

The paper aims to clarify some aspects less addressed in the literature and to highlight the importance of innovative managerial strategies for using intangible resources to increase sustainable competitive advantage and company value, in terms of theoretical and empirical studies, conducted at national and international level. Thus, the author proposes a theoretical research model based on the premise that both the sustainable competitive advantage and the market value of a company can be influenced by the way intangible resources are used in innovative exploitation and exploratory strategies.
Co-creating sustainable competitiveness in an unpredictable business reality
Authors: De Valon Tiphaine , Cegarra-Navarro Juan Gabriel , Garcia-Perez Alexeis , Martínez-Martínez Aurora
Published: August 2022

Businesses nowadays must perform in an overcrowded market. Globalisation and access to technologies have made the competition fierce and the differentiation complicated. New challenges related to sustainability have emerged as a result of an increased environmental awareness from consumers. Their demand is shifting, and companies must adapt to the competitive pressures, social demands and legal regulations towards sustainability. However, implementing sustainable initiatives might be costly and do not ensure enhanced financial outcomes. Co-creation was found in the literature to offer potential solutions to sustainability challenges by enabling businesses to benefit from knowledge from external resources, involving consumers in their activities and seeking their engagement and approval. But the current research lacks a sustainable applicability. Hence, this theoretical study reviewed the current literature to offer an updated state of the art regarding sustainable co-creation between businesses and consumers. It aims to provide answers to how this joint collaboration can support sustainable development for companies, what type of value it generates for both parties, and what factors make market competitiveness possible despite an absence of financial value creation. We were able to create a theoretical framework including the following factors: 1) Value sharing, which considers engaging consumers’ proactive behaviours to overcome inertia and engage in a process of sustainable self-improvement; 2) Relationship management, where common interests will be merged, and consumers empowered to investigate how sustainable development can be implemented in an objective of positive long-term co-evolution; 3) Knowledge sharing, where mutual learning and understanding will lead to a synergy of power and allows to elaborate a marketable and sustainable value proposition; and 4) Innovation, which is the outcome of an efficient co-creation, where internal and external capabilities are recombined to overcome barriers related to sustainable development. The study concluded that a combination of those factors results in competitive value creation.
Estimating the value creation probability of mergers and acquisitions events using option pricing models Evidence from Europe and USA
Authors: Anton George , Cheptiş Alexandra , Vasilca Miruna-Mihaela , Vid Alin-Ioan
Published: August 2022

This paper is proposing a new research approach to mergers and acquisitions value creation analysis. By using option pricing models we propose a new methodology on how mergers and acquisitions decisions can be analyzed using a quantitative approach, especially suitable for conglomerate type of mergers and acquisitions, where cost and revenue synergies do not represent a direct or visible financial benefit. Currently, the M&A research field is focusing mainly on the stock returns or cost synergies by the horizontal types of M&A events. The main implications of the results presented in this paper can confirm whether the top 20 M&A events that have taken place in the USA and Europe in the last 20 years were ones with high probability of value creation. In the future, this can become an important analysis point useful for the investment banking industry when evaluating M&A investments. On top, it can expand the field of research in the M&A environment.
The circular economy in Romania and in the EU Member States
Authors: Potârniche Marilena E. , Giucă Andreea Daniela , Stoica Gabriela Dalila , Sterie Cristina Maria
Published: August 2022

The transition to a circular economy could bring many benefits, such as: Reducing the pressure on the environment, improving the security of supply of raw materials, increasing the competitiveness of businesses, stimulating innovation, boosting economic growth and not least creating new jobs. The aim of the work is to highlight the situation of Romania compared to the Member States of the European Union as regards indicators specific to the circular economy. To achieve this aim, the following indicators have been analyzed: Trade in recyclable raw materials, circular use rate of material, municipal recycling rate, and private investment in circular economy sectors, both at Romanian level and across all EU Member States, in the period 2010-2020. The countries with the largest amounts of recycled raw materials are Germany and the Netherlands with more than 1,5 million tons in 2020 and the country-wide extra-EU trade in recyclable raw materials was 25,2 thousand. The Netherlands, Belgium and France are the leading figures for the use rate of recyclable metals. However, the highest recycling rate was registered by Germany with 67%, with Romania among the last countries.
The Influence of Hofstede’s Cultural Dimensions on Attitude Towards Change and Innovation in Oganizations
Authors: Firican Diana Andreea
Published: August 2022

As the COVID-19 pandemic has radically changed the business landscape in the last years, some organizations were able to adapt to the new environment and continue to function, some thrived, seeing unmatched growth, while others disappeared forever. Even before the COVID-19 pandemic, adaptability had already been deemed to be an important organizational capability, which ensured an organization stayed relevant in the market. With the pandemic, the ability to adapt has become essential to the organizations’ survival. Additionally, a large body of research was dedicated to the importance of innovation, which has been shown to have a positive impact on organizations’ competitiveness, growth and overall results. While adaptability is a response to the changes in the external environment of an organization, innovation consists in the change being generated inside the organization. Thus, an organization reacts to change by being adaptable and generates change by being innovative. Given that both capabilities are of importance to an organization’s success, this paper performs a literature review of the factors influencing the organizations’ adaptability and innovativeness, specifically the cultural factors, based on the well-established Hofstede Cultural Model. The results show that both adaptability and innovativeness are influenced by the cultural dimensions in different ways. However, not all cultural dimensions can be influenced to the same extent, some being more malleable than others. This means that organizations must aim to influence the most malleable cultural dimensions in order to increase their adaptability and innovativeness, to improve their overall performance.
Financial education and the perception of prosperity among emerging adults
Authors: Bulău Carmen Mihaela , Lungu Violeta
Published: August 2022

Emerging maturity is conceptualized as a distinct stage of life in industrialized countries and encompasses the third decade of life. At this stage, young people are facing decisions about the transition to adulthood. Autonomy and independence from parental support is one of the milestones of emerging maturity. There is not much research on the role of financial education in fulfilling this development task. This study investigates how the level of financial education shapes the perception of prosperity in emerging adult and helps to achieve financial autonomy. This study involved 103 emerging adults, first-year students at the Academy of Economic Studies, University of Bucharest, and Polytechnic University (average age 20.1, SD = 0.78). The study had a quantitative, cross-sectional, descriptive, and inferential design. The results obtained show that: 1. the higher the level of financial education, the more intrinsic the perception of prosperity, 2. the higher the level of financial education, the higher the financial autonomy, 3. between the level of financial education and the profile of the graduated high school / academic choice relations are insignificant. For data collection, questionnaires were developed for which the internal consistency of the items was calculated, and this is valid for this stage of the research.
Innovation in communication in the European funding process
Authors: Piuaru Brenda-Andreea Muşa , Tescaşiu Bianca
Published: August 2022

European funds contribute to the well-being of communities that succeed in attracting this type of funding. This paper aims at revealing the innovative capacity of communication in the financing process through European Funds, given the multitude of theoretical communication models. Beyond the limits imposed by the law, public authorities involved in the European funding process, although operating within a relatively rigid regulated framework, may increase the number of communication methods and practices, in order to better fulfil their mission of satisfying public needs. An exploratory research on the financing process of European Structural and Investment Funds was conducted, considering the theoretical approaches in the field of communication, as well as the relatively low absorption rate of European Funds, for outlining the real dimensions of the communication problem. The communication was analyzed via eight elements: transmitter, receiver, channel or means of propagation, message, common codes (including coding and decoding), feedback, feedforward and noise. The main results show that the communication process in the field of European funding can be approached from a multitude of perspectives: type, purposes and means of communication, content of communication and its effects, the protagonists involved etc. The paper proposes an approach to communication from a marketing perspective. By applying specific marketing techniques, favorable attitudes, opinions and behaviors can be generated in terms of accessibility of financing through European funds. This can lead to an increase in the absorption rate of European funds, which can result in more innovation, more business growth, higher revenues (through taxes) for the public sector and finally, given the snowball effect, the ultimate purpose: welfare for society as a whole.
Synchronization of the business cycle with that of the eurozone after accession to the European Union. The case of Romania
Authors: Matei Elena Florentina , Mindrican Ioana Manuela
Published: August 2022

This article provides an overview and update on the degree of convergence of Romania with the Eurozone, in terms of business cycles and also taking into account the economic context and economic policies implemented. The synchronization of the business cycle of the Romanian economy with that of the Eurozone is an essential condition for the sustainable adoption of the single currency, because the higher the level of synchronization, the lower the accession costs will tend to benefits, and in the end there will be no severe shocks to the economy. The main objective of this document is to identify the level of convergence of the two business cycles for the period 2007-2020, in order to highlight the level of preparation of the Romanian economy in terms of the adoption of the euro. If a low level of synchronization of the two business cycles is identified, the shocks will be asymmetric and will lead to a strong negative impact on the economy and will make the country in question a peripheral state of the Eurozone.
Accounting for the future: practice, Artificial Intelligence and regulation
Authors: Oprea Octavian , Hoinaru Răzvan , Păcuraru-Ionescu Cătălin-Paul , Neamţu Daniela
Published: August 2022

This paper is a feed-in regulatory analysis for the ongoing EU legislation on Artificial Intelligence (AI). The main argument is that accounting was left behind by this EU proposal for regulation and its three risk categories. The future of the Artificial Intelligence Act is both inclusive (specifically addressing many activities) and exclusive (takes out from the scope of regulation certain industries and applications). Despite the rather extensive sphere of (non)application of the proposal of regulation, accounting falls in a third category of unaddressed industries. Our argument is that accounting should be taken into consideration and be included in one of the categories, according to the regulatory proposal classification. By creating a regulatory framework for accounting in AI, a certain sense of certainty can be created in the markets and in the profession. Accounting is a decision-making tool with control capacity over financial and social behaviour, due to its informing capacity and pro-cyclicity influencing value, hence being able to create risks and possible moral hazards.
Wage Rigidity and Labour Market Changes in the Context of the Pandemic – The Case of Romania
Authors: Gherghina Elena Mădălina
Published: August 2022

The COVID-19 pandemic has impacted all economic sectors, and the shocks have been felt strongly in the labour market. The objective of this paper is to identify the trends on the Romanian labour market, to approximate and evaluate the impact that the COVID-19 pandemic has had on the sectors of activity and, implicitly, on the employees of these sectors. In order to carry out this analysis, relevant indicators are used for the evolution of the salary and the number of employees, for the period January 2016 - October 2021. After this section, the analysis is focused on the period 2020-2021, when the entire society faced the negative effects generated by the COVID-19 pandemic. In this paper, the disproportionate impact of the crisis at the level of the labour force is highlighted, the employees working in the Manufacturing sector being the most severely affected, almost half of the jobs lost during the lockdown period being in this sector. Another sector that was strongly impacted by measures to prevent the spread of the virus is Accommodation and food service activities. However, in this case, the number of employees returned in 2021 to the value recorded in the pre-pandemic period.
Macro-economic evolutions during the COVID-19 health crisis – large versus small European countries
Authors: Tudorache Adrian Tudor , Nicolescu Luminița
Published: August 2022

The COVID-19 crisis affected the global economy at unprecedented and unexpected levels. Practitioners and researchers are concerned about the economic consequences of the crisis and analyses of the economic impacts of the health crisis are required. The present paper had as main objective to analyze the economic evolution of European countries during the main years of the COVID-19 pandemics, respectively 2020 and 2021. The methodology used is based on descriptive statistics for a few macroeconomic indicators and for the evolution of the COVID-19 cases and also on statistics based on correlation between these indicators. The European countries were categorized in four groups according to geographical region and size and a few countries were selected for analysis from each group. The research revealed that the impact of the COVID-19 outbreak was large in all analyzed economies in respect to GDP evolution. Inflation seemed to be highly affected by the COVID-19 outbreak, both in terms of evolution of the indicator with increases in all countries, but also in terms of correlation with the number of COVID-19 cases in the case of Western European countries. CEE countries were more affected by the COVID-19 crisis in terms of inflation, compared to Western European countries.
Development of digitization services in the context of the COVID-19 pandemic a solution for Smart City. Case study: Romania
Authors: Gavriluţă Turtă Ioana Marinela , Nepotu Grigore , Ciochină Alexandru Bogdan , Cuciureanu Maria-Simona
Published: August 2022

The COVID-19 pandemic has led to the globalization of services worldwide, due to restrictions that have been imposed for a certain period. In this context, the digitization of services, both in rural and urban areas, contributes to the development of Smart City and its integration into communities. Romania is a country that does not have digitized services, which are under development, but the COVID-19 pandemic has created a forced “opportunity” to accelerate this process. Also, the areas that had digitization projects, being integrated in Smart City projects, were advantaged during the period of restrictions during the state of emergency in 2020 or the state of alert from 2020 to 2022. The digitization of services depends on several factors such as infrastructure and internet connectivity. At European level it is the DESI index (index of the digital economy and society) which highlights digital competitiveness in the Member States of the European Union, the main areas of analysis being human capital, broadband connectivity, integration of digital technologies by businesses and digital public services. This study will focus on the development of digital public services between 2020 and 2021 and will see if they have been affected by the coronavirus pandemic. The indicators analyzed will be “people who use the Internet to interact with public authorities”, “level of Internet access of households”, “households with broadband access”. The paper will highlight the state of digitalization of public services in Romania and how these services are ranked in the European context.
Some ways to modernise and increase the efficiency of trade and investment flows between the European Union and South East Asian Countries
Authors: Damoc Adrian-Ioan , Al-Kasawnih Akad
Published: August 2022

Since the beginning of the covid-19 pandemic, the European Union’s economic and sociopolitical strength has been subjected to a harsh test as all societal actors, in very specific ways, were obliged to keep the virus from spreading out of control, minimise the economic damage and ensure timely and urgent treatment for covid-19 patients while also managing social unrest and the rise of Eurosceptic rhetoric. As is characteristic for the modern trading landscape, supply chains have also been negatively affected by the pandemic, with figures plummeting sharply in 2020 with varying rates of recovery in 2021. Analysis of the current global geoeconomic context and the European Union’s external trade and investment partnerships suggests that it could benefit from focusing its attention on one of the world’s fastest growing economies, namely the South-East Asia region. In the present paper, we investigate the extent to which trade reliance on China and/or the United States, economic complexity, political uncertainty and number of dominant foreign trade partners have influenced the economic performance of the European Union and South-East Asia during the pandemic. The results and the implications thereof are discussed in the broader context of a possible paradigmatic change in the European Union’s foreign trade.
A conceptual comparative approach on personal AI assistants and external service robots
Authors: Pelau Corina , Barbul Maria , Bojescu Irina
Published: August 2022

In the past years artificial intelligence (AI) has become an important subject for both companies and consumer due to the growth of personal AI assistants and external service robots. It is clear that many aspects of our life are not like they used to be. The fact that every one of us is sooner or later going to incorporate various AI functions in daily routine activities becomes somehow certain. It is not only our home-life that is transforming, but also the way we, as consumers, are going to interact with different product and service providers. In this paper we provide a comparative literature review on the challenges and research topics regarding personal AI assistants and external service robots. While the personal AI assistants intervene more in the private sphere of the consumer, the relation to the external service robots is more distant. The results of our literature review show that the relation between consumer and external service robot is more characterized by interaction, enjoyment and engagement, it is expected to have a parasocial friendship relation between consumer and personal AI assistants. Taking this difference of perspective the two types of AI will be differently involved in the future business and marketing activities of companies.
A case report of a first pregnant woman with late-onset multiple acyl-CoA dehydrogenase deficiency in Saudi Arabia
Authors: Sharfa Shirin , Sunbul Rawda , Masseri Zainab , AlSayed Moeenaldeen , Al-Hassnan Zuhair
Published: August 2022

Background: Multiple acyl-CoA dehydrogenase deficiency (MADD), also known as glutaric aciduria II, is a rare autosomal recessively inherited disorder of inborn error of metabolism. It can mainly be presented in three phenotypes: severe neonatal onset with a dysmorphic feature, neonatal-onset without dysmorphic features, and less severe mild late-onset phenotype.
Case presentation: A 34-year-old Saudi female previously healthy, Para 4, with severe metabolic acidosis, rhabdomyolysis intrapartum was presented to us. Her previous pregnancy history and deliveries were unremarkable; she has three healthy sons. Since the beginning of this pregnancy, she complained of fatigability and muscle weakness which was progressive with time. At 36 weeks of gestation, she was presented to the emergency room with labor pain. She deteriorated rapidly with significant drowsiness. Her arterial blood gas showed severe metabolic acidosis with a high anion gap and normal lactate. She was intubated and underwent emergency cesarean delivery under general anesthesia. After the operation, she was sent to the intensive care unit. She passed away after a few days. A molecular test confirmed the diagnosis of MADD.
Conclusion: First, late-onset MADD is a rare, underdiagnosed disease in adults. Second, the biochemical diagnosis of late-onset MADD is challenging as it mimics medium chain acyl CoA dehydrogenase deficiency which makes the molecular diagnosis essential for diagnosis. Third, for any unexplained myopathy, cardiac dysfunction, encephalopathy, or metabolic acidosis, metabolic disorders must be considered as early consultation with metabolic service.
Press freedom and censorship during Covid-19 pandemic: the case of Cebu City
Authors: Baba Kenneth Michael M , Alkuino Kent Andrei S. , Tictic Ezra P. , Dungog-Cuizon Ana Leah Dungog-Cuizon
Published: August 2022

Censorship, in all its forms, has always been a means by which freedom is being checked and regulated. In hindsight, for the state and its people, censorship must always be exercised with caution to avoid suppression of the constitutionally guaranteed freedom of the press. Moreover, freedom of the press is crucial in times of crisis, as in the case of a global pandemic named COVID-19. The Philippines, regarded as the world's texting capital and one of the widest in social media use, feel the convenience of getting the news right at the fingertips, apart from avoiding physical contact in compliance with health protocols. The study zeroes in on Cebu City, regarded as one of the country's largest voting populations and a newsmaker in terms of its policies vis-a-vis the pandemic. It delves into the juxtaposition of press freedom and censorship in Cebu City against the backdrop of the pandemic. This study is anchored on Bunn’s New Censorship Theory, Scammel’s foundations on the Index of Censorship, and the ever-developing Libertarian Theory. Further, it employed the Colaizzi method to explore the experiences of Cebu-based media practitioners and media institutions. In this vein, press freedom and censorship are not mutually exclusive. The presence of one does not preclude the other; they can actually co-exist. The exercise of press freedom very well depends on the personal values of the media practitioners and institutions.
Selected Filipino-Chinese small-medium entrepreneur communication management practices in the Philippines
Authors: Ditan Carolina D.
Published: August 2022

Chinese entrepreneurial activities diaspora in Southeast Asia have received ample attention in academic debates. This academic attention is related to an impressive business presence of ethnic Chinese companies in the region, which seek explanations. Several works of literature have emerged arguing that because of specific cultural traits (personal networks, ethnic affinity, and Confucian Work Ethics), ethnic Chinese businesses function successfully in their new home countries and business contacts across borders. This study aims to describe the communication management practices of Filipino-Chinese Small Medium Enterprises (SME) entrepreneurs in terms of planning, leadership, organising and control. The method used in this study is phenomenology with data collection using interviews with six respondents and three Philippine government officials. The conclusion of this study shows that in terms of risk behaviour, the Filipino-Chinese entrepreneurs had a positive outlook by believing that taking risks is one key factor in business success.
Digital marketing communication for archery sports equipment on Instagram @vienetharcheryofficial
Authors: Putranto Teguh Dwi , Vallejo Ephraim Theodore S.
Published: August 2022

The sports equipment business is one of the businesses that is currently starting to develop. Supported by the desire of the community to engage in sports, one of which is archery, Vieneth Archery Official, one of the archery equipment shops, takes advantage of this situation. The purpose of this study was to digitally determine the marketing communication of archery sports equipment on Instagram @vienetharcheryofficial. The method used in this research is Krippendorff content analysis which is carried out by collecting data on the Instagram account @vienetharcheryofficial from 1 May 2022 to 30 May 2022. The conclusion of this study shows that Vieneth Archery, as an archery equipment shop, carries out digital marketing communications through @vienetharcheryofficial Instagram posts dominated by public relations and publicity efforts.
Citocinas séricas da resposta imune em adultos e neonatos na imunidade treinada induzida por BCG: revisão sistemática
Authors: Lemes Lara Fidelis Vieira , Sobrinho Hermínio Maurício da Rocha , Costa Iasmim Ribeiro da , Silva Antonio Márcio Teodoro Cordeiro , Pfrimer Irmtraut Araci Hoffmann
Published: August 2022

Objetivo: Avaliar as principais citocinas caracterizadas após a indução da imunidade treinada pela vacina BCG, em adultos e neonatos saudáveis, e verificar se os resultados encontrados nesses dois grupos apresentam semelhanças ou divergências nas citocinas. Métodos: Trata-se de uma revisão sistemática da literatura, utilizando os bancos de dados do NCBI (plataforma PubMed) e Periódicos Capes para busca e seleção dos artigos, utilizando cinco descritores. Resultados: Os resultados demonstraram que não há grandes diferenças entre os achados das citocinas dosadas nos adultos e nos neonatos, após a indução da imunidade treinada, pela vacina BCG. Estes resultados sugerem que a imunidade treinada ocorre em qualquer idade. Dois dos estudos selecionados abordavam resultados de citocinas dosadas após um ano, demonstrando a permanência da imunidade treinada induzida pela BCG neste período. A IL-6, IL-1β e o TNF-α foram as citocinas que mais se destacaram nos dez artigos selecionados, pois demonstraram altos níveis séricos na maioria dos estudos. Considerações finais: É necessário realizar mais estudos de longo prazo para o melhor entendimento da imunidade treinada, o que beneficiaria o avanço de novas vacinas visando proteção humana contra diferentes tipos de infecções por micro-organismos.
Uma análise sobre as cardiomiopatias: hipertrófica e dilatada
Authors: Ribeiro Letícia Campitelle Perri , Felippe Rodrigo Maia Santos , Sousa Marianna Ramalho de , Fonseca Ester Tannus Marques da , Baptista Vanessa da Silva , Siqueira Emílio Conceição de
Published: August 2022

Objetivo: Analisar as características das Cardiomiopatias Hipertrófica (CMH) e Dilatada (CMD). Revisão bibliográfica: As cardiomiopatias são doenças intrínsecas do coração caracterizadas por alteração estrutural do miocárdio, com etiologias tanto genéticas quanto adquiridas. Pacientes portadores de cardiomiopatia hipertrófica ou dilatada podem apresentar-se desde assintomáticos até intenso comprometimento das atividades diárias, com manifestações clínicas importantes como dispneia, dor no peito, fadiga, edema periférico, palpitações, arritmias e, em casos mais graves, até morte súbita cardíaca. A prevalência média dessas condições na população mundial é de 1:250 a 1:500 em adultos, apesar da expressão da doença ocorrer mais frequentemente em jovens. Essas condições afetam a contratilidade cardíaca e hemodinâmica, e, dependendo da extensão do comprometimento miocárdico, podem prejudicar severamente a qualidade de vida dos pacientes. Considerações finais: A cardiomiopatia hipertrófica caracteriza-se pelo aumento da espessura do ventrículo esquerdo. Já a cardiomiopatia dilatada é definida pela dilatação do ventrículo esquerdo ou biventricular, com prejuízo na fração de ejeção. Nesse contexto, o conhecimento sobre tais patologias mostra-se essencial a fim de promover diagnóstico e terapêutica adequada, proporcionando qualidade de vida aos pacientes.
A importância da limpeza hospitalar para a prevenção e controle das infecções relacionadas à assistência à saúde
Authors: Barros Ediléia de Jesus Sousa , Baptista Suelen Suzy Gomes , Passos Alexsanderson de Souza , Araujo Jackeline Oliveira de , Lima Marcela Fernandes de , Vale Rafaela Larissa Tavares do , Braga Kathleen Kaliandra Lima , Magalhães Regina Oliveira , Carmo Thalita Gomes do
Published: August 2022

Objetivo: Entender a importância da limpeza hospitalar para a prevenção de Infecções Relacionadas à Assistência à Saúde. Métodos: A pesquisa apresentada neste trabalho trata-se de uma revisão integrativa com características descritiva e exploratória de estudos publicados acerca da prevenção de IRAS, a busca foi realizada por meio de literatura disponível em bases de dados na internet, sendo elas: Scientific Eletronic Library Online (SCIELO), Centro Latino-Americano e do Caribe de Informação em Ciência da Saúde (LILACS), mecanismo de busca do Google Acadêmico e Periódicos da CAPES. Resultados: Através dos descritores, foram encontrados um total de 127 artigos nas bases de dados propostas. Após aplicação de critérios de inclusão e exclusão, foram selecionados 12 artigos. Considerações finais: Não basta apenas a higienização do ambiente hospitalar para a prevenção de IRAS, também é importante e necessário que todo profissional que trabalha em ambiente hospitalar tenha conscientização, sendo assim, o enfermeiro deve orientar a equipe a respeito da higiene hospitalar e atentar-se a assepsia do paciente internado, pois este torna-se um hospedeiro susceptível.
Trends in scientific publication of traditional game learning models in physical education and sports in Indonesia: A bibliometric analysis
Authors: Alpen Joni , Dlis Firmansyah , Hernawan  , Widiastuti  , Apriani Leni , Kurniawan Edi , Sofyan Davi
Published: August 2022

The development of scientific publications in the field of traditional game learning models requires more research in order to compete with other fields. The goal of this research is to look at the production of scientific publications based on the traditional game learning model. The Scopus database and various bibliometric indicators such as global publication trends, most active authors, number of citations, and author keywords are used to collect publications. From 1996 to 2022, a total of 473 publications on traditional game learning models are discovered. Data in Comma-separated Values (CSV) and Research Information Systems (RIS) formats are exported to Microsoft Excel, Publish or Perish (PoP), and VOSviewer software for this review. According to the research findings, 2021 has been the year with the most publications, with 139 documents. Universitas Pendidikan Indonesia is listed as the most active affiliate, with up to 80 academic scientific works published. Suherman, A., from Universitas Pendidikan Indonesia, is the most active writer, with 13 publications to his credit. With 60 documents, the Journal of Physics Conference Series is the most actively published scientific resource. Some of the research limitations in our paper include the selection of keywords that do not represent the entire search data, data filters, and data providers. It should be noted that a variety of other databases can be used to obtain data. This bibliometric study sheds light on future research directions in the field of traditional game learning models.
Continuous and competitive circuit training: Methods to increase vo2max on young badminton player
Authors: Ariani Luh Putu Tuti Ariani , Sudiana I Ketut , Kusuma Ketut Chandra Adinata
Published: August 2022

The characteristic of badminton game is a sport with high intensity and intermitten actions. It takes the ability of a high level of physical condition, especially the level of VO2max to reach peak performance. There are many kinds of training method to increase VO2max, one of them is continuous circuit training and competitive circuit training. The purpose of this study is to discover the effect of continuous circuit training and competitive circuit training and to determine a more effective method to increase VO2max. This study is pre-experimental study with pre-test and post-test group design. The sample consisted of 60 badminton athletes in range of 9 – 12 years old and all of them were male. The instrument used to measure VO2max level was Multistage Fitness Test (MFT). VO2max data before and after treatement were analyzed with descriptive statistic and t-test on 5% significancy standard. Based on the data analysis, the following results were obtained: (1) There was a significant effect on the level of VO2max in the continuous circuit training group with sig 0.000 values; (2) There was a significant effect on the level of VO2max in the competitive circuit training group with values sig 0.000; and (3) There was no significant difference between the continuous circuit training group and the competitive circuit training group. So it can be concluded that continuous and competitive circuit training can increase the VO2max of young badminton players.
A 3D Extra-Large Pore Zeolite Enabled by 1D-to-3D Topotactic Condensation of a Chain Silicate
Authors: Li Jian , Gao Zihao Rei , Lin Qing-Fang , Liu Chenxu , Bai Risheng , Gao Fangxin , Lin Cong , Zhang Siyao , Deng Hua , Mayoral Alvaro , Fan Wei , Luo Song , Chen Xiaobo , He Hong , Camblor Miguel A. , Chen Fei-Jian , Yu Jihong
Published: August 2022

Stable silica-based zeolites with increased porosity are in demand to allow adsorption and processing of large molecules, but challenge our synthetic ability. Here we report a novel, highly stable pure silica zeolite, ZEO-3, with a multidimensional, interconnected system of extra-large pores open through windows made by 16 and 14 SiO4 tetrahedra, which is the less dense polymorph of silica known so far. This zeolite is formed by an unprecedented 1D-to-3D topotactic condensation approach from a chain silicate. With a specific surface area over 1000 m2/g, ZEO-3 shows an extraordinary performance for Volatile Organic Compounds abatement and recovery and potential as a catalyst for the conversion of bulky molecules after incorporating heteroatoms as active centers.
Environmental health, racial/ethnic health-disparity, and climate impacts of freight transport in the United States
Authors: Thind Maninder P. S. , Tessum Christopher W. , Marshall Julian D.
Published: August 2022

Atmospheric emissions from freight transportation contribute to human health and climate damage. Here, we quantify and compare three environmental impacts from inter-regional freight transportation in the contiguous United States: mortality attributable to PM2.5 air pollution, racial-ethnic disparities in mortality from PM2.5, and CO2 emissions. We compare all major transportation modes (truck, rail, barge, aircraft) and all major inter-regional routes (~30,000 routes). Our study is the first to comprehensively compare each route separately, and the first to explore racial-ethnic exposure disparities by route and mode, nationally. Impacts (health, health-disparity, climate) per tonne of freight are largest for aircraft. Among non-aircraft modes, per tonne, rail has the largest health and health-disparity impacts and the lowest climate impacts, whereas truck transport has the lowest health impacts and greatest climate impacts – an important reminder that health and climate impacts are often but not always aligned. For aircraft and truck, average monetized damages per tonne are larger for climate impacts than for PM2.5 air pollution; for rail and barge, the reverse holds. We find that average exposures for inter-regional truck and rail are the highest for White non-Hispanic people, from barge is highest for Black people, and from aircraft is highest for people who are mixed/other race. Level of exposure and disparity among racial-ethnic groups vary in urban and rural areas. This research can be used to inform, for a given inter-regional origin and destination, which freight mode offers the lowest environmental health, health-disparity, and climate impacts.
QM/MM Simulations of the Covalent Inhibition of the SARS-CoV-2 Main Protease: Four Compounds and Three Reaction Mechanisms
Authors: Grigorenko Bella L. , Polyakov Igor V. , Giudetti Goran , Faraji Shirin , Krylov Anna I. , Nemukhin Alexander V.
Published: August 2022

The search for efficient inhibitors of the SARS-CoV-2 enzymes remains important due to the continuing COVID-19 pandemic. We report the results of computational modeling of the reactions of the SARS-CoV-2 main protease (MPro) with four potential covalent inhibitors. Two of them, carmofur and nirmatrelvir, have been shown experimentally the ability to inhibit MPro. Two other compounds, X77A and X77C, were designed computationally in this work, derived from the structure of X77, a non-covalent inhibitor forming a tight surface complex with MPro. We modified the X77 structure by introducing warheads capable of efficient chemical reactions with the catalytic cysteine residue in the MPro active site. The reactions of the four molecules with MPro were investigated by quantum mechanics/molecular mechanics (QM/MM) calculations. According to calculations, the reactions for all four compounds are exothermic, with sufficiently low barriers, suggesting efficient inhibition of the enzyme. From the chemical perspective, the four compounds react with MPro following three distinct mechanisms. In all cases, the reaction is initiated by a nucleophilic attack of the thiolate group of the deprotonated cysteine residue from the catalytic dyad Cys145-His41 of MPro. In the case of carmofur and X77A, the covalent binding of the thiolate to the ligand involves the formation of the fluoro-uracil leaving group. The reaction with X77C follows the nucleophilic aromatic substitution SNAr mechanism. The reaction of MPro with nirmatrelvir, which has a reactive nitrile group, leads to the formation of the covalent thioimidate adduct with the thiolate of the Cys145 residue in the enzyme active site.
Synthesis and Calculations of Wurtzite Al1−xGdxN Heterostructural Alloys
Authors: Smaha Rebecca W. , Yazawa Keisuke , Norman Andrew , Mangum John S. , Brennecka Geoff L. , Zakutayev Andriy , Bauers Sage R. , Gorai Prashun , Haegel Nancy
Published: August 2022

Al1−xGdxN is one of a series of novel heterostructural alloys involving rare earth cations with potentially interesting properties for (opto)electronic, magnetic and neutron detector applications. Using alloy models in conjunction with density functional theory, we explored the full composition range for Al1−xGdxN and found that wurtzite is the ground state structure up to a critical composition of x = 0.82. The calculated temperature-composition phase diagram reveals a large miscibility gap inducing spinodal decomposition at equilibrium conditions, with higher Gd substitution (meta)stabilized at higher temperatures. By depositing combinatorial thin films at high effective temperatures using radio frequency co-sputtering, we have achieved the highest Gd3+ incorporation into the wurtzite phase reported to date, with single-phase compositions at least up to x ≈ 0.25 confirmed by high resolution synchrotron grazing incidence wide angle X-ray scattering. High resolution transmission electron microscopy on material with x ≈ 0.13 confirmed a uniform composition polycrystalline film with uniform columnar grains having the wurtzite structure. Expanding our calculations to other rare earth cations (Pr and Tb) reveals similar thermodynamic stability and solubility behavior to Gd. From this and previous studies on Al1−xScxN, we elucidate that both smaller ionic radius and higher bond ionicity promote increased incorporation of group IIIB cations into wurtzite AlN. This work furthers the development of design rules for new alloys in this materials family.
Shining a Light on Photoresponsive Type III Porous Liquids
Authors: Brand Michael , Rankin Nicola , Cooper Andrew , Greenaway Rebecca
Published: August 2022

Porous materials are the subject of extensive research because of potential applications in areas such as gas adsorption and molecular separations. Until recently, most porous materials were solids, but there is now an emerging class of materials known as porous liquids. The incorporation of intrinsic porosity or cavities in a liquid can result in free-flowing materials that are capable of gas uptakes that are significantly higher than conventional non-porous liquids. A handful of porous liquids have also been investigated for gas separations. Until now, the release of gas from porous liquids has relied on molecular displacement (e.g., by adding small solvent molecules), pressure or temperature swings, or sonication. Here, we explore a new method of gas release that involves photoisomerisable porous liquids comprising a photoresponsive MOF dispersed in an ionic liquid. This results in the selective uptake of CO2 over CH4, and allows gas release to be controlled by using UV light.
Cellulose dissolution and gelation in NaOH(aq) under controlled CO2 atmosphere: supramolecular structure and flow properties
Authors: Reyes Guillermo , King Alistair W. T. , Koso Tetyana V. , Penttilä Paavo A. , Kosonen Harri , Rojas Orlando J.
Published: August 2022

We investigate the interplay between cellulose crystallization and aggregation with interfibrillar interactions, shear forces, and the local changes in the medium's acidity. The latter is affected by the CO2 chemisorbed from the surrounding atmosphere, which, combined with shear forces, explain cellulose gelation. Herein, rheology, nuclear magnetic resonance (NMR), small and wide-angle X-ray scattering (SAXS/WAXS), and focused ion beam scanning electron microscopy (FIB-SEM) are combined to unveil the fundamental factors that limit cellulose gelation and maximize its dissolution in NaOH(aq). The obtained solutions are then proposed for developing green and environmentally friendly cellulose-based materials.
A homoleptic tris(diphosphacyclobutadiene) tripledecker sandwich complex
Authors: Roedl Christian , Hierlmeier Gabriele , Wolf Robert
Published: August 2022

The synthesis and characterisation of [Co2(η4 P2C2tBu2)2(µ:η4:η4-P2C2tBu2)] (1) is described, featuring two cobalt atoms and three diphosphacyclobutadiene ligands. This compound is the first triple-decker sandwich complex which exclusively contains cyclobutadiene ligands.
Approach To: Delirium
Authors: Mukharyamova Alfiya
Published: August 2022

Delirium is a common and serious geriatric syndrome with core features of acute onset and inattention. It is often underdiagnosed and is associated with many adverse outcomes, such as prolonged hospitalization, institutionalization, functional impairment and death. This review summarizes an approach to the recognition, work-up, management and prevention of delirium.
Congenital Cytomegalovirus Infection: Transmission, Diagnosis and Treatment.
Authors: Manan Muhammad Romail , Manan Hamna
Published: August 2022

Introduction: Cytomegalovirus (CMV) is a linear, dsDNA virus that is regarded as the prototype of the Betaherpesvirinae subfamily of viruses. It has an established endemic status in certain locations around the globe, and is also reported to be the most prevalently occurring congenital infection in humans. Furthermore, Cytomegalovirus is notorious for being a persistent lifelong pathogen that poses a threat of reactivation as well.
Discussion: Congenital cytomegalovirus infection causes numerous ophthalmologic, and neurologic sequelae, and is also known for being the principal reason behind sensorineural hearing loss of non-genetic etiology in neonates. These symptoms, if present, may give rise to a premonition of congenital Cytomegalovirus disease, and so, a diagnosis can be established  through serology, radiology, and  PCR of salivary, urinary, or dried blood spot samples. Timely administration of ganciclovir or valganciclovir has proven to be effective in managing symptomatic cases of congenital CMV.
Conclusion: A well-timed delivery of pharmacological and non-pharmacological interventions is necessary to achieve healthy developmental outcomes for the neonate. Moreover, there is still  a need to study the role of antiviral therapy in silent cases since asymptomatic patients are at a risk of developing long-term clinical sequelae as well.
Relevance: An estimated 60-90% of women of child-bearing age get infected with Cytomegalovirus, and Congenital CMV disease is reported in 0.2-2.4% of all live births. Therefore, in order to develop effective screening and management protocols, it is vital to educate healthcare professionals regarding the various aspects of this congenital infection.