bluuebunny/crossref_metadata_2025 huggingface dataset:
LONGEVIDADE DAS PRÓTESES DE ARTICULAÇÃO TEMPOROMANDIBULAR NO TRATAMENTO PARA DEGENERAÇÕES ARTICULARES: UMA REVISÃO DE LITERATURA
Authors: Santos Beatriz Sales da Silva , Aguero Pedro dos Santos Anjo e , Sodré hiago Marcelino , Carvalho Larissa Betânia Lacerda Araújo de , Carvalho Lidylara Lacerda Araújo , Santos Mayana Almeida Araújo dos , Rosa Rayza de Almeida , Almeida Raimara Lima de , Ribeiro Guilherme Soares , Ferreira Camila Ribeiro
Published: September 2024

The temporomandibular joint (TMJ) is essential for functions such as chewing, speaking and swallowing. When degenerated by conditions such as rheumatoid, ankylosis or severe trauma, replacement with dentures can alleviate pain and restore jaw function. Although advances in materials, such as titanium alloys and biocompatible polymers, and in prosthesis design have improved biological compatibility and wear resistance, the longevity of these prostheses still faces important challenges. Factors such as surgical technique, the body’s inflammatory response and quality of materials are decisive for long-term success. Recent studies highlight the importance of customizing prostheses, especially with the use of 3D printing, which allows better adaptation to the patient’s anatomy, increasing durability and reducing complications. However, complications such as infection and dislocation are still concerns, and the need for surgical revisions is greater in patients with chronic inflammatory conditions. Careful patient selection and appropriate postoperative management are crucial to minimize these risks. Future research should focus on improving materials and techniques, as well as developing more refined protocols for patient selection and postoperative management, aiming to improve patients’ quality of life and increase the longevity of TMJ prostheses.
Correlation of New Media and Post-Cinema
Authors: Gorokhova V. O.
Published: September 2024

In the modern world, the main processes that occur in the field of culture and art are somehow connected with digitalization. It becomes obvious that there is a need for a theoretical understanding of the events taking place in the media environment and their structuring, followed by the identification of characteristics of the forms of the so-called new cinema or post-cinema. The current work involves a conceptual understanding of the phenomenon of post-cinema and the identification of interactions with new media through immersive practices of involving the viewer, both inside the artistic space of the film (reducing narrative, leveling genre structure, new forms of use of pre-digital media), and through external manifestation on the part of the viewer (streaming, the ability to influence the plot, AR and VR technologies, gaming and so on).
The Image of a Genius in Biopics
Authors: Osinkin D. S.
Published: September 2024

The article is devoted to the study of the problems of representation of the image of genius in biographical feature (staged) cinema. As part of the research, using the example of the dramaturgy of the films “Sin” (2019, directed by A.S. Konchalovsky) and “Andrey Rublev” (1966, directed by A.A. Tarkovsky), an attempt is made to demonstrate specific principles and dramatic techniques with which the task of artistic research of the phenomenon of human genius is solved in biographical films.
The story by B. Vasiliev Not listed and its screen adaptation by A. Malyukov I am a Russian soldier: the main images and conflicts
Authors: Smagina S. A.
Published: September 2024

The article is devoted to a comparative analysis of Boris Vasiliev's novel “I was not on the list” (1974) and its film adaptation “I am a Russian Soldier” (1995, dir. Andrey Malyukov). As a result of a critical comparison of the images and conflicts of the two works, the author comes to the conclusion that B. Vasiliev's story “Did not appear in the lists” tells about the feat of the real unknown defenders of the Brest fortress. Andrey Malyukov's film based on the material of B. Vasiliev's story about the defense of the Brest fortress tells a completely different story — about the trampled dignity of the Russian army, which, starting with perestroika in the media space, becomes the object of ridicule, criticism and vilification. And also about the Russian people, to whom, under the guise of abstract humanism, a sense of guilt for the very fact of their existence begins to be imposed.
Actualised Transformation of a Monster in Big Screen Adaptations of Richard Matheson’s I am Legend
Authors: Litvina D. V.
Published: September 2024

The article analyses the image of the monsters in Richard Matheson’s novel I Am Legend and its three big screen adaptations. It studies the change in features and interpretations of the monstrous antagonists but also of the monstrous protagonist for the purpose of actualising the original text in cultural and historical context. The conclusion is drawn about the reasons behind these transformations, as well as supposed attitude towards the main conflict of the work.
Performance Analysis of a Solar-Powered Rotary Drum Composter for Optimized Food Waste Management
Authors: Danga Ma. Angelica B. , Lim John Kevin C. , Jingco Jude Milbert C. , Manalo Justine Roi P. , Marquez Joshua G. , Tangcuangco Alma L. , Tiria Genesis M. , Macaspac Jezeth Vince B.
Published: September 2024

The annual value of food waste generated worldwide has already reached a staggering $1 trillion. This amounts to 1.3-1.4 billion tons, or one-third of the food produced for human consumption, that goes to waste each year. The Food Center at Don Honorio Ventura State University faces a similar issue, with a weekly production of 21.5 kg of food waste. To address this increasingly concerning issue, a solar-powered rotary drum composter driven by a DC motor was developed. This composter is designed to accommodate up to 20 kg of food waste. Analysis of the composter’s motor performance reveals significant relationships between voltage, current, speed, torque, efficiency, and load. The voltage exhibits an inversely proportional relationship with the load, steadily decreasing from 24.8 V to 23.3 V as the load increases, while the current shows a directly proportional relationship, consistently rising from 4.1 A to 9.84 A with the increased load. Further examination of torque and speed in relation to load indicates a directly proportional and inversely proportional relationship, respectively. Torque increases from 6.68 Nm to 27.23 Nm with increasing load, while speed decreases from 72.74 rpm to 55.16 rpm. As for efficiency, it was found that the composter operates most efficiently when the drum is loaded with 12 kg, beyond which efficiency gradually declines with increasing load up to 20 kg. This decline signifies the diminishing returns associated with higher loads, highlighting the importance of load optimization for sustained efficiency in composter operation.
La Gerencia emergente un camino por transitar en el Siglo XXI
Authors: Vieras Cristina
Published: September 2024

El propósito del presente artículo es realizar un ejercicio prospectivo de las posiblestendencias económicas para Venezuela en los años por venir. Muchas probablemente seanlas expectativas que se generan en este campo y sobre todo en la posibilidad de presuponerlas, sin duda, pero más que explorar el campo especulativo, se hace desde unaperspectiva de esperanza para el pueblo venezolano. El acercamiento a estas posibilidadesde análisis se hacen desde la necesidad de nuevos estilos gerenciales, más que del crudodiagnóstico de la realidad que nos toca vivir, y desde esas nuevas formas de mirar elpanorama de un nuevo país, se aventura a proponer nuevas formas de integración. A lo largo de este análisis, trataremos de enhebrar los nuevos estilos de liderazgo con los procesos de transformación que serán necesarios, la implantación de las tecnologías, también los nuevos enfoques laborales y la relación de la empresa con la universidad para mejorar los estándares del personal profesional que se va a requerir. Una gerencia renovada para salir del estancamiento, ha de vencer la resistencia coyuntural de abrirse al mercado libre, debe apartar las restricciones para ventilar una economía basada en las ventajas competitivas del mercado, sin perder la visón o principios misionales que se deben encarar para la cercanía cierta con los trabajadores como principales ejecutores, y sin duda, para corresponder a las exigencias de una población ávida de mejoras en su calidad de vida. Por tanto, no basta con políticas de responsabilidad social empresarial, sino, de empujar un sano desarrollo humano sustentable.
La Educación, un valor esencial de José Gregorio Hernández.
Authors: Pérez Esclarín Antonio
Published: September 2024

En los momentos en que estamos sufriendo en Venezuela una profunda crisis humanitaria, agudizada por la pandemia del Covid 19, y la educación, tan necesaria para la reconciliación y el progreso, a duras penas sobrevive, el ejemplo de José Gregorio y su amor a la educación, debe motivarnos a trabajar por entrega y entusiasmo para rescatar la educacióncomo medio esencial para reconstruir a Venezuela. José Gregorio fue un alumno ejemplar y un profesor responsable y entregado. Apasionado de la formación permanente, durante toda su vida mostró un hambre insaciable de aprender pero no para aumentar el currículo y considerarse superior a los demás, sino para crecer como persona, como ciudadano y como cristiano y de este modo servir mejor a Venezuela y los venezolanos.
Vigencia del Doctor José Gregorio Hernandez
Authors: González Cruz Francisco
Published: September 2024

El Dr. José Gregorio Hernández es el personaje más conocido y querido de los venezolanos. En todas partes están sus imágenes, diversas y creativas, desde la tradicional figura de pie vestido de negro y sombrero, hasta rústicas representaciones populares o sofisticadas obras de arte. Desde artistas consagrados hasta tiernos niños lo han plasmado en dibujos y pinturas, esculturas y grabados, medallas y estampas, objetos de uso cotidiano o destinadas a la contemplación. Y su presencia está en los cuellos de la gente, en las carteras, en los altares familiares, en las capillitas de los barrios y en las iglesias, en los carros particulares y en busetas, en los consultorios médicos y en los de los curanderos. De él se han escrito biografías y novelas, cientos de ensayos y escritos periodísticos, versos y canciones
José Gregorio Hernández: El Médico que se enfrentó a la Gripe Española.
Authors: Linares María Fernanda
Published: September 2024

El Dr. José Gregorio Hernández nació el 26 de octubre de 1864 en Isnotú, estado Trujillo. Estudió sus primeras letras en su pueblo natal y se trasladó posteriormente a Caracas para estudiar en el Colegio “Villegas”, graduándose de Bachiller en Filosofía en el año de 1884. Antes de comenzar a hablar su destacada carrera médica, es importante mencionar su formación académica, la cual soldó los pilares para el inicio de la misma. Se doctoró en medicina en la Universidad Central de Venezuela el 29 de junio de 1888. Su tesis la defendió ante Jurado y presentó sobre dos temas: La Doctrina de Laennec y la Fiebre Tifoidea en Caracas, ambos temas relacionados con enfermedades bacterianas, campo en el cual se verá centrada su profesión médica posteriormente. Es considerado fundador de la Bacteriología en Venezuela
Por los Caminos del Pensamiento Crítico
Authors: Linares de Méndez Ana
Published: September 2024

En el ámbito de la reflexión teórica, han sido diversos los autores que han hecho posible el estudio crítico, complejo y transdiciplinario de la realidad social en diferentes contextos y épocas. Para entender con criterios de amplitud algunas ideas de estos autores, es necesario caminar junto a sus líneas de pensamientos en sus diversos espacios históricos, de manera que podamos analizar su visión del mundo, aunque no la compartamos. Estos autores, son los pensadores críticos, seres humanos insertos en su contexto social, capaces de ver más allá de las apariencias, de profundizar en variados aspectos de su entorno, quienes aportaron sus ideas, pensamientos y reflexiones con el firme propósito del abordaje significativo de sus realidades sociales para analizarlas, comprenderlas y transformarlas
Atributos de marca asociados a los emprendimientos de educación musical en formatos virtuales. Un acercamiento de la educación en el arte a las necesidades del entorno
Authors: Torres Granadillo Fernando , Fernández Roberto Andrés
Published: September 2024

La presente investigación tiene como objetivo central, analizar los atributos de marca de los emprendedores de la educación musical en Venezuela, En este sentido, se asumió una posición ontológica que considera al emprendedor como un ser humano enérgico, dinámico, proactivo y sobretodo seropositivo. De igual forma, se considera que la educación puede activar o desactivar los procesos de emprendimiento al incidir en la concepción emprendedora y los procesos asociados. Desde el punto de vista metodológico, se estableció un anclaje epistemológico de tipo fenomenológico y se optó por una investigación de tipo descriptiva y de campo, cumpliendo con los apartados teóricos y metodológicos, los principales hallazgos evidencian una concepción de dichos atributos las cuales estarían ligados a las necesidades académicas que subyacen en los estudiantes como usuarios del servicio educativo, presentando modelos de pensamiento totalmente cambiantes y vinculados al acceso de la tecnología del entorno.
Desarrollo humano sostenible. Una visión humana
Authors: Paredes Baptista Karelis del Valle
Published: September 2024

Los años y los acontecimientos han dividido el mundo, acontecimientos que marcan el fin y el inicio de nuevos procesos históricos, dando paso a nuevas formas de organización. Hemos vivido dentro de la historia de la humanidad el nacimiento y la muerte de Cristo, guerras mundiales, avances tecnológicos, por mencionar algunos; que, en definitiva, nos hacen capaces de asumir retos para construir la sociedad que todos soñamos. Hoy día, somos el resultado de esos procesos y también somos los hombres constructores del mañana. Razón por la cual, la Organización de las Naciones Unidades (ONU), el Programa de las Naciones Unidas para el Desarrollo (PNUD), el Banco Mundial (BM), e innumerables organizaciones unen esfuerzos en la tarea de trabajar por la gente y para la gente. Preocuparse por el hombre como eje y motor de todo desarrollo, es la prioridad. Debemos hacer de este siglo, el siglo de la equidad, la justicia y la igualdad; logrando el pleno desarrollo de la persona. Se presenta este paradigma como una visión humana, sustentada en valores que hacen referencia a los estándares compartidos de lo que es correcto, deseable y digno de respeto por quienes los asumen, internalizan y ponen en práctica. El desarrollo humano sostenible nos muestra una visión humanista del crecimiento, reconociendo la importancia de la naturaleza, la cultura, la tecnología, la economía y la sociedad, para la felicidad humana.
Etnohistoria y Arquetipo del Desarrollo Humano Sustentable: Hermenéutica Simbólica del Bioderecho del siglo XIX Latinoamericano
Authors: Gómez Romero Danny Francis
Published: September 2024

La presente Investigación tiene como finalidad sustantiva el estudio del desarrollo humano sustentable, para asegurar la protección efectiva de los derechos fundamentales y la igualdad ante la ley de todos los ciudadanos y su resguardo hacia el medio ambiente. Dicha reflexión se basa en el enfoque etnohistórico de capacidades: desarrollado por Amartya Sen (1990), este paradigma propone que el desarrollo debe centrarse en la ampliación de las capacidades individuales, está; adscrita a la temática: perspectiva del desarrollo humano sustentable en la sociedad del conocimiento, tiene como finalidad sustantiva realizar una reflexión etnohistórica arquetípica del perfil que tiene el ser como ente diplomático, garantista, jurisdiccional con relación a otras figuras que, en el ámbito regional e internacional, tiene como objetivo, la protección de personas.- medio ambiente. De igual forma, se realiza una reseña de los postulados de, Amartya Sen así como la importancia de la garantía jurisdiccional como medio para proteger los derechos fundamentales de las personas frente al poder estatal, lo que ha tenido una gran influencia en la forma en que se entiende el papel de los tribunales y de la justicia en las sociedades democráticas Este análisis reflexivo lo haremos de la mano de la etnohistoria documental y teniendo como con-texto de interpretación, comprensión y explicación el espacio hermenéutico del conocimiento epocal del bioderecho y cómo éste fue pensado y puesto en práctica por aquella sociedad cuyo impacto aún resuena en la cultura arquetípica sustentable de Latinoamérica actual.
La educación desde las dimensiones del desarrollo humano sustentable
Authors: Briceño Portillo Marilyn
Published: September 2024

En el marco del desarrollo humano sustentable, se contempla el rol de las instituciones de educación universitaria como agentes transformadores de realidades, en este contexto, este documento tiene como propósito contribuir con una serie de reflexiones con base en los postulados teóricos del desarrollo humano sostenible apuntando a generar una propuesta de formación académica en proyectos vivenciales enmarcados en las dimensiones económica, humana, ambiental, tecnológica e institucional del DHS, esto a partir de un recorrido desde las concepciones de Maturana (2017), haciendo un análisis reflexivo de la Encíclica Laudato SI, con la conceptualización del desarrollo integral, las causas de la crisis en la cual se encuentra inmerso el planeta, con un sentido de ocupación al respecto, exponiendo cómo se puede ser partícipe de las soluciones. Frente a este escenario, la educación se presenta en una posición privilegiada para contribuir con la capacitación de las personas en diversas áreas de conocimiento en función del servicio a sus pares, comunidades y el planeta.
Analisis Strategi dan Teknik Tendangan Sabit Dalam Olahraga Pencak Silat: A Systematic Literature Review
Authors: Thouhid Maulana Febrian , Raya M Aziz S
Published: September 2024

Hook kick is a crucial technique in the Indonesian martial art of Pencak Silat that requires precise strategy for its effectiveness. This research employs a systematicliteraturereview method to explore relevant studies on hook kick strategies in Pencak Silat. The method involves searching scientific articles and other pertinent sources to identify commonly used strategies and the scientific evidence supporting them. Analysis of the literature reveals that hook kick strategies can be categorized into several key elements, including proper body positioning, correct foot techniques, utilization of body momentum, and effective distance management. These findings provide deeper insights into how this technique can be effectively applied in combat situations and training. The research outcomes are expected to offer profound insights applicable to training and skill development in Pencak Silat, contributing to the enhancement of overall standards in this martial art.
Keywords: Sickle Kick Technique, Sports, and Pencak Silat
Flexible planning of assessment, a lever towards assessment for learning?
Authors: Yerly Gonzague , Monney Nicole
Published: September 2024

The article discusses the contribution of flexible planning of assessment as a lever to support teachers in implementing assessment for learning in the classroom. It proposes a theoretical reflection on the contribution of “flexible” planning, i.e. planning that is thorough and structured (hierarchical) but that also leaves room for adjustments during the interaction (dynamic) and involves the students (interactive). The contribution of the article has been to link the scientific findings on planning the teaching-learning process with those on the assessment of learning. The objectives of this paper are to 1) specify what “flexible” planning of assessment is, 2) to discuss the contributions of such planning in the implementation of assessment for learning in the classroom.
Seguimiento de dos tejones criados en cautividad y liberados en el Parque Natural de Gorbeia (Álava, País Vasco), con especial referencia a la selección de tejoneras
Authors: Paniagua Diana , Illana Andrés , Echegaray Jorge
Published: September 2024

Hemos estudiado la adaptación a un nuevo entorno y la selección y uso de refugios diurnos por un macho y una hembra de tejón Meles meles (Linnaeus, 1758) criados en cautividad y liberados en el Parque Natural de Gorbeia (Álava, País Vasco), mediante técnicas de radioseguimiento. El área de estudio de 2.304 ha fue delimitada con las radiolocalizaciones. Los tejones fueron radiolocalizados en sus madrigueras en un total de 57 ocasiones (24 la hembra y 33 el macho). El macho utilizó 8 tejoneras y la hembra 5, llegando a compartir una de ellas con otros tejones. El análisis de selección realizado con las variables de caracterización de madrigueras muestra preferencia por aquellas zonas situados entre 600 y 800 m, orientadas hacia el O y NO, con pendientes del terreno cuyo rango varía entre el 20 y 30%, a una distancia del agua de entre 50 y 100 m y a una distancia de las pistas forestales de entre 25 y 50 m. El resto de variables consideradas no mostraron diferencias significativas.
INVESTIGATION OF THE USABILITY AND USER EXPERIENCE OF MOBILE LANGUAGE LEARNING APPLICATIONS: BUSUU, DUOLINGO, AND MEMRISE
Authors: Soyupak Ozan , İpek Haluk
Published: September 2024

This study explores the effects of usability and user experience of mobile language learning applications on learning process by evaluating three popular applications Busuu, Duolingo, and Memrise. The data were collected by user interviews and the diary method. With the help of the think-aloud method, user interviews were actualized, and in addition to that the researcher kept a diary by trying all three applications for 10 days. Nielsen’s Heuristics and an adapted version of these heuristics were used within the framework of this study. The researcher's diaries were coded with the help of heuristics. Findings emphasize the strong connection between the user experience and mobile language learning applications’ efficiency. Results indicate that even the adapted version of heuristics has shortages, and it is needed to be developed for future researches. As a result, investigation of user experience is recommended to be evaluated separately for the different phases of application usage in further studies.
A NEW PERSPECTIVE ON CHINESE RED GLAZE
Authors: Ergül Berk , Başkırkan Hasan
Published: September 2024

Glazes obtained by the reduction method, also called Chinese red or copper red in the literature, were first seen on porcelains of the Tang Dynasty (618-907) and Northern Song Dynasty (960-1126) periods in China. These glazes, which require a very difficult process to produce, are obtained by reducing the copper compounds in the recipe in the kiln. From its historical process to the present day, the surface of Chinese red glazes has been desired to be shiny and smooth, and their production has been carried out according to this principle. Within the scope of this study, a new artistic perspective was wanted to be brought to Chinese red glazes and instead of a smooth surface appearance, a pin hole image, known as a glaze defect, was desired. For this purpose, silicon carbide (SiC) was used to achieve the desired effect. Under normal conditions, the reduction process is carried out when the kiln cools down after neutral firing. However, a different perspective was tried to be provided by developing an alternative firing method to the traditional Chinese red glazes obtained by reduction. In order to contribute to the language of discourse in art ceramics, a new proposal is presented with the interpretation of Chinese red glazes.
INVESTIGATION OF TYPOGRAPHY USE AND FONT DESIGN IN VIRTUAL REALITY ENVIRONMENT
Authors: Bağriaçik Zeynep Sena , Pehlivan Baskın Zeynep
Published: September 2024

Thanks to developing technology, the use of virtual reality has become increasingly widespread. With the widespread use of virtual reality, design in virtual reality has become increasingly important. One of the design elements that should be considered in the virtual reality environment is typography. Different design and production processes have occurred in the use of typography in the virtual reality environment. Nowadays, typography can be used more uniquely in different forms in virtual reality environments. This article focuses on the relationship between virtual reality and typography, one of the new medium that emerged with the development of technology. This article is a qualitative study and the usage of typography in the virtual reality environment is examined. Based on the reviews, a font design was created. The project produced was produced as an example project for the use of the font in the virtual reality environment.
INTEGRATION OF DIGITAL FABRICATION LABORATORIES AND COMPUTATIONAL DESIGN INTO THE ARCHITECTURE CURRICULUM IN TÜRKİYE
Authors: Öztürk Kösenciğ Kamile , Güneş Yağmur Burcu , Özbayraktar Mehtap
Published: September 2024

The discipline of architecture undergoes transformation practically, cognitively, and pedagogically due to the widespread use of digital design and fabrication technologies in design processes. This paper aims to eluctade the integration of digital fabrication and computational design with architectural design education at undergraduate level. For this purpose, this study examined the undergraduate course contents and spatial conditions of leading universities with digital fabrication laboratories under three headings: digital design, digital fabrication, and spatial reflections. In addition, this research applied semi-structured interviews with the relevant faculty members of three universities that have robotic tools to obtain more detailed information about their pedagogical approaches. According to this study, the curriculum and laboratories are rapidly changing. As a result, architecture departments are expanding their facilities by building laboratories and tools that have the potential for architectural education to fill the gap between practice and theory. However, there are economic limitations to implementing digital fabrication technologies in terms of the tools and materials used by hundreds of students. This research discusses the requirements, potentials, and limitations of theoretical and practical training through digital fabrication tools that should be included in these courses in the curriculum.
16. VE 17. YÜZYIL SANATÇILARININ FIRÇALARINDAN BİR KADIN KAHRAMAN; JUDİTH VE HOLOFERNES YORUMLARI
Authors: Kara Bilgin Filiz
Published: September 2024

Kahramanlık kavramı genellikle erkeklere atfedilmiş bir olgu olarak ortaya çıksa da tarih kadın kahramanlarla doludur. Savaş zamanlarında, toplumların zor durumda kaldığı hallerde elini erkekler kadar taşın altına koyan bu kadınlardan bazıları hikâyelere, destanlara, roman ve resimlere konu olmuş ve kendini tarihin tozlu sayfalarından sıyırmayı başarmışlardır. Judith ve Holofernes hikâyesi, Rönesans ve Barok dönemlerinde sanatçılar arasında büyük ilham kaynağı olmuş, farklı sanatsal yaklaşımlarla ele alınmış önemli bir konudur. Bu tablolar, Judith'in cesareti ve Holofernes'in ölümü üzerinden güçlü bir drama ve sembolizm sunarak, ressamların hayal gücünü ve teknik yeteneklerini zorlamıştır. Eski ahitte ele alınan hikâyenin anlatımını her sanatçı kendi perspektifinden ele almış, eser sanatçının yaşadığı bölge, dönem ve cinsiyetine göre farklı anlatılmıştır. Bu sebeple 16. ve 17. yüzyılda konuya dair betimlemeler, dönemin sanat anlayışlarını ve toplumsal değerlerini yansıtan ilginç bir doküman niteliği taşımaktadır. Bu çalışmada kahramanlık, erdem, şiddet ve intikam duygularının ön plana çıktığı Judith efsanesini ele alan eserlerin hem duygu hem de göstergeler yönünden betimsel incelemesi yapılmış, konu Holofernes’in katli sonrasını anlatan eserler ile sınırlandırılmıştır.
BİLGİ GÜVENİLİRLİĞİ SORUNUNA KARŞI YENİ HABERCİLİK PRATİKLERİ VE DOĞRULUK KONTROL REFLEKSLERİ
Authors: Okay Ahmet Serkan , Gezmen Başak
Published: September 2024

Hakikat sonrası’ ya da ‘hakikat ötesi’ şeklinde Türkçede karşılık bulan post truth kavramı, bilginin sorgulanmadan, araştırılmadan doğru olduğu kabul edildiği bir dönemi tanımlamaktadır. Tarihin eski dönemlerinden beri sahte bilgi, asparagas kavramları karşımıza çıkmakta ancak post truth dönemde salt gerçeklikten koparak duyular üzerinden bir dünya kurgulanmaktadır. Dijital dünya bu sürece hız kazandırarak, sahte ve yalan pratiklerini hayatın normalleri arasına yerleştirmektedir. Böylece gerçek ve yalan arasındaki ayırımı yapmak giderek zorlaşmaktadır. Bu noktada gerçek bilgiye ulaşmak için bireylerin dijital dünyada medya okur yazarlığı reflekslerinin gelişmiş olması gerekmektedir gerekmektedir. Günümüzde doğruluk kontrol merkezleri ve teyit konusu giderek önem kazanmaktadır. Araştırma kapsamında, Türkiye’nin bilinen önemli doğruluk kontrol merkezleri ile gerçekleştirilen derinlemesine görüşmeler ve 6-12 Şubat Yas Dönemi ekseninde yapılan doğruluk kontrol merkezleri içerik paylaşım analizleri sonucunda, teyit konusundaki farkındalık ölçütleri ve çıkarımlar tartışılarak ortaya konmuştur.
SOSYAL MEDYADA KRİZ YÖNETİMİ: KURUMSAL ÖZÜR DİLEME ÜZERİNE OLUMSUZ BİR OLAY İNCELEMESİ
Authors: Ekmekçi Zeynep
Published: September 2024

Sosyal interaktif medya doğası ve ulaşabildiği kitlenin büyüklüğü açısından örgütlerin ve markaların kriz yönetmekte güçlük çekebileceği bir alan olabilmektedir. Örgütlerin bu alanın dinamiklerini iyi tanımaları ve çözümlemeleri gerekmektedir. Dolayısıyla kriz yönetiminin bu dinamiklere uygun şekilde hızlı ve şeffaf yürütülmesi önem kazanmaktadır. Krizler beklenmedik zamanlarda ve aniden ortaya çıkan durumlar olduklarından örgütlerin kriz öncesi hazırlıkları olmalıdır. Ayrıca hız çağında yaşanıldığından esnek ve hızlı yanıt verebilir bir kriz çözüm yeteneğine sahip olunmalıdır. Çalışmada sosyal medyada karşılaşılan kriz, evreleri bağlamında örnek olayla incelenmiştir. Çalışmada sosyal medyanın gücünü ve markalar üzerindeki etkisi araştırılmaktadır. Bir olay incelemesi üzerinden sosyal medyada yaşanan bir kriz durumunun nasıl yönetildiğini ve marka imajının nasıl etkilendiğini ele alınmaktadır. Çalışma, kriz anında markanın sosyal medya üzerinden nasıl tepki verdiğini, kriz iletişimi sürecinde hangi stratejilerin işe yaradığını ve marka imajının kriz sonrasında nasıl etkilendiğini ortaya koymaktadır. Ayrıca, kriz yönetimi sürecinde markanın aldığı dersler ve gelecekte benzer durumların önlenmesi için öneriler de sunulmaktadır. Bu olay incelemesi, sosyal medyanın markalar üzerindeki etkilerini anlamak ve kriz anlarında etkili iletişim stratejileri geliştirmek isteyen araştırmacılar ve profesyoneller için önemli bir kaynak oluşturmaktadır. Kriz yönetimi sürecinin başarılı bir şekilde yürütülmesi, markaların itibarını korumak ve güvenilirliğini artırmak açısından kritik öneme sahiptir.
NAZİ PROPAGANDA SİNEMASININ POPÜLER SİNEMAYA GÖRSEL TASARIM AÇISINDAN ETKİLERİ: YILDIZ SAVAŞLARI
Authors: Gürocak Tolga
Published: September 2024

Nazi Almanya’sında kültür ve sanatın her alanını kontrol ederek Nazi ideolojisini meşrulaştırmanın en önemli araçlarından olan sinema, Leni Riefenstahl’in filmlerinde hem anlatıyı hem de görselliği amaçları doğrultusunda ustaca kullanmıştır. Dünya Savaşı’nı kaybedilmesine rağmen Nazi propaganda sineması Hollywood sinemasında etkilerini göstermeye devam etmiştir. 1970’lerden sonra punk rock kültürünün yükselişe geçmesiyle müzik kliplerinde giderek görünürlüğü artan Nazi propaganda sineması estetiği gerek eleştirel amaçla gerekse bağlamından koparıp sadece estetik bir öge olarak kullanılmıştır. Popüler kültürün kült yapımlarından Yıldız Savaşları (Star Wars) film serisinin görsel tasarım aşamasında sıklıkla başvurulan kaynaklardandır. Bu çalışmada, George Lucas’ın yarattığı Yıldız Savaşları serisinde Leni Riefenstahl’in İrade’nin Zaferi filminden ilham alınarak üretilen görsel kompozisyonlar, görsel tasarım ögelerinden denge, tekrar, vurgu, oran-orantı ve zıtlık açısından incelenmiştir. Sonuç olarak Nazi propaganda sinemasında karşılaşılan görsel tasarım biçimlerinin Yıldız Savaşları’nın kronolojik olarak ilk filmlerinde daha çok görsel unsur olarak, serinin ilerleyen filmlerinde ise içerikle görselliği Nazi dönemiyle bağdaştırarak kullanıldığı belirlenmiştir.
EKOELEŞTİRİ KURAMI BAĞLAMINDA MİYAZAKİ’NİN RÜZGÂRLI VADİ ANİMASYON FİLMİ
Authors: Yıldırım Sağlam Bahar
Published: September 2024

Ekoloji çalışmaları 19. yüzyılda sanayileşmenin yarattığı çevre kirliliğine karşı ortaya çıkar ve 20. yüzyılda yaygınlık kazanır. “Ekoloji” kelimesini, köken olarak oikos ve logos sözcüklerinden türeten Alman zoolog Ernst Haeckel, terimi ilk defa 1866 yılında kullanır. Rachel Carson’un 1962 yılında yayınladığı, pestisitlerin doğaya ve canlı yaşamına zarar verdiğini vurguladığı eseri Sessiz Bahar ile modern çevreciliğin başladığı kabul edilir. Ekoeleştiri; çevre, insan, doğa, hayvan arasındaki ilişkileri inceler. Bozulan ekolojik dengeleri ve bu durumun sebeplerini, sonuçlarını tartışır. Hayao Miyazaki’nin Rüzgârlı Vadi (1984) animasyon filmi de, insan ve doğa arasındaki ilişkiyi sorgular. İnsanın doğaya hükmetme arzusunu ve bu arzuyla doğaya verdiği zararı perdeye aktarır. Miyazaki, Rüzgârlı Vadi filmi ile insanoğlunun zehirli bir ormana çevirdiği dünyaya sorular sorar. Doğa ile insan arasındaki uyum ve dengenin nasıl kurulacağına işaret eder. Makalede öncelikle, ekoeleştiri kuramı üzerinde durulacaktır. Daha sonra ise, film ile ekoeleştiri kuramı arasındaki ilişki; ekolojik yıkım, denge ve uyum, yitik cennet alt başlıkları altında ele alınacaktır.
Linalool’s Multifaceted Antimicrobial Potential: Unveiling its Antimicrobial Efficacy and Immunomodulatory Role Against Saprolegnia parasitica
Authors: Tang Tao , Zhong Weiming , Tang Puyu , Dai Rongsi , Guo Jiajing , Gao Zhipeng
Published: September 2024

Saprolegnia parasitica
(
S
.
parasitica
) is one of the most virulent oomycete species in freshwater aquatic environments, causing severe saprolegniasis and leading to significant economic losses in the aquaculture industry. Thus far, the prevention and control of saprolegniasis face a shortage of medications. Linalool, a natural antibiotic alternative found in various essential oils, exhibits promising antimicrobial activity against a wide range of pathogens. In this study, the specific role of linalool in protecting
S
.
parasitica
infection at both
in vitro
and
in vivo
levels was investigated. Linalool showed multifaceted anti-oomycetes potential by both of antimicrobial efficacy and immunomodulatory efficacy. For
in vitro
test, linalool exhibited strong anti-oomycetes activity and mode of action included: (1) Linalool disrupted the cell membrane of the mycelium, causing the intracellular components leak out; (2) Linalool prohibited ribosome function, thereby inhibiting protein synthesis and ultimately affecting mycelium growth. Surprisingly, meanwhile we found the potential immune protective mechanism of linalool in the
in vivo
test: (1) Linalool enhanced the complement and coagulation system which in turn activated host immune defense and lysate
S
.
parasitica
cells; (2) Linalool promoted wound healing, tissue repair, and phagocytosis to cope with
S
.
parasitica
infection; (3) Linalool positively modulated the immune response by increasing the abundance of beneficial Actinobacteriota; (4) Linalool stimulated the production of inflammatory cytokines and chemokines to lyse
S
.
parasitica
cells. In all, our findings showed that linalool possessed multifaceted anti-oomycetes potential which would be a promising natural antibiotic alternative to cope with
S
.
parasitica
infection in the aquaculture industry.
Deficiency of Orexin Receptor Type 1 in Dopaminergic Neurons Increases Novelty-Induced Locomotion and Exploration
Authors: Xiao Xing , Yeghiazaryan Gagik , Eggersmann Fynn , Cremer Anna L , Backes Heiko , Kloppenburg Peter , Hausen A Christine
Published: September 2024

Orexin signaling in the ventral tegmental area and substantia nigra promotes locomotion and reward processing, but it is not clear whether dopaminergic neurons directly mediate these effects. We show that dopaminergic neurons in these areas mainly express orexin receptor subtype 1 (Ox1R). In contrast, only a minor population in the medial ventral tegmental area express orexin receptor subtype 2 (Ox2R). To analyze the functional role of Ox1R signaling in dopaminergic neurons, we deleted Ox1R specifically in dopamine transporter-expressing neurons of mice and investigated the functional consequences. Deletion of Ox1R increased locomotor activity and exploration during exposure to novel environments or when intracerebroventricularely injected with orexin A. Spontaneous activity in home cages, anxiety, reward processing, and energy metabolism did not change. Positron emission tomography imaging revealed that Ox1R signaling in dopaminergic neurons affected distinct neural circuits depending on the stimulation mode. In line with an increase of neural activity in the lateral paragigantocellular nucleus (LPGi) of Ox1R
ΔDAT
mice, we found that dopaminergic projections innervate the LPGi in regions where the inhibitory dopamine receptor subtype D2 but not the excitatory D1 subtype resides. These data suggest a crucial regulatory role of Ox1R signaling in dopaminergic neurons in novelty-induced locomotion and exploration.
Cardiac glycosides restore autophagy flux in an iPSC-derived neuronal model of WDR45 deficiency
Authors: Papandreou Apostolos , Singh Nivedita , Gianfrancesco Lorita , Budinger Dimitri , Barwick Katy , Agrotis Alexander , Luft Christin , Shao Ying , Lenaerts An-Sofie , Gregory Allison , Jeong Suh Young , Hogarth Penelope , Hayflick Susan , Barral Serena , Kriston-Vizi Janos , Gissen Paul , Kurian Manju A , Ketteler Robin
Published: September 2024

Beta-Propeller Protein-Associated Neurodegeneration (BPAN) is one of the commonest forms of Neurodegeneration with Brain Iron Accumulation, caused by mutations in the gene encoding the autophagy-related protein, WDR45. The mechanisms linking autophagy, iron overload and neurodegeneration in BPAN are poorly understood and, as a result, there are currently no disease-modifying treatments for this progressive disorder. We have developed a patient-derived, induced pluripotent stem cell (iPSC)-based midbrain dopaminergic neuronal cell model of BPAN (3 patient, 2 age-matched controls and 2 isogenic control lines) which shows defective autophagy and aberrant gene expression in key neurodegenerative, neurodevelopmental and collagen pathways. A high content imaging-based medium-throughput blinded drug screen using the FDA-approved Prestwick library identified 5 cardiac glycosides that both corrected disease-related defective autophagosome formation and restored BPAN-specific gene expression profiles. Our findings have clear translational potential and emphasise the utility of iPSC-based modelling in elucidating disease pathophysiology and identifying targeted therapeutics for early-onset monogenic disorders.
Shortcutting from self-motion signals: quantifying trajectories and active sensing in an open maze
Authors: Xu Jiayun , Girardi-Schappo Mauricio , Béïque Jean-Claude , Longtin André , Maler Leonard
Published: September 2024

Animals navigate by learning the spatial layout of their environment. We investigated spatial learning of mice in an open maze where food was hidden in one of a hundred holes. Mice leaving from a stable entrance learned to efficiently navigate to the food without the need for landmarks. We developed a quantitative framework to reveal how the mice estimate the food location based on analyses of trajectories and active hole checks. After learning, the computed “target estimation vector” (TEV) closely approximated the mice’s route and its hole check distribution. The TEV required learning both the direction and distance of the start to food vector, and our data suggests that different learning dynamics underlie these estimates. We propose that the TEV can be precisely connected to the properties of hippocampal place cells. Finally, we provide the first demonstration that, after learning the location of two food sites, the mice took a shortcut between the sites, demonstrating that they had generated a cognitive map.
Blood metabolomic profiling reveals new targets in the management of psychological symptoms associated with severe alcohol use disorder
Authors: Leclercq Sophie , Ahmed Hany , Amadieu Camille , Petit Géraldine , Koistinen Ville , Leyrolle Quentin , Poncin Marie , Stärkel Peter , Kok Eloise , Karhunen Pekka J , De Timary Philippe , Layé Sophie , Neyrinck Audrey M , Kärkkäinen Olli , Hanhineva Kati , Delzenne Nathalie M
Published: September 2024

Alcohol use disorder (AUD) is a global health problem with limited therapeutic options. The biochemical mechanisms that lead to this disorder are not yet fully understood, and in this respect, metabolomics represents a promising approach to decipher metabolic events related to AUD. The plasma metabolome contains a plethora of bioactive molecules that reflects the functional changes in host metabolism but also the impact of the gut microbiome and nutritional habits. In this study, we investigated the impact of severe AUD (sAUD), and of a three-week period of alcohol abstinence, on the blood metabolome (non-targeted LC-MS metabolomics analysis) in 96 sAUD patients hospitalized for alcohol withdrawal. We found that the plasma levels of different lipids ((lyso)phosphatidylcholines, long-chain fatty acids), short-chain fatty acids (i.e. 3-hydroxyvaleric acid) and bile acids were altered in sAUD patients. In addition, several microbial metabolites, including indole-3-propionic acid, p-cresol sulfate, hippuric acid, pyrocatechol sulfate, and metabolites belonging to xanthine class (paraxanthine, theobromine and theophylline) were sensitive to alcohol exposure and alcohol withdrawal. 3-Hydroxyvaleric acid, caffeine metabolites (theobromine, paraxanthine and theophylline) and microbial metabolites (hippuric acid and pyrocatechol sulfate) were correlated with anxiety, depression and alcohol craving. Metabolomics analysis in post-mortem samples of frontal cortex and cerebrospinal fluid of those consuming a high level of alcohol revealed that those metabolites can be found also in brain tissue. Our data allow to for the identification of neuroactive metabolites, from interactions between food components and microbiota, which may represent new targets in the management of neuropsychiatric diseases such as sAUD.
Tumor-infiltrating nerves functionally alter brain circuits and modulate behavior in a mouse model of head-and-neck cancer
Authors: Barr Jeffrey , Walz Austin , Restaino Anthony C , Amit Moran , Barclay Sarah M , Vichaya Elisabeth G , Spanos William C , Dantzer Robert , Talbot Sebastien , Vermeer Paola D
Published: September 2024

Cancer patients often experience changes in mental health, prompting an exploration into whether nerves infiltrating tumors contribute to these alterations by impacting brain functions. Using a mouse model for head and neck cancer and neuronal tracing, we show that tumor-infiltrating nerves connect to distinct brain areas. The activation of this neuronal circuitry altered behaviors (decreased nest-building, increased latency to eat a cookie, and reduced wheel running). Tumor-infiltrating nociceptor neurons exhibited heightened calcium activity and brain regions receiving these neural projections showed elevated Fos as well as increased calcium responses compared to non-tumor-bearing counterparts. The genetic elimination of nociceptor neurons decreased brain Fos expression and mitigated the behavioral alterations induced by the presence of the tumor. While analgesic treatment restored nesting and cookie test behaviors, it did not fully restore voluntary wheel running indicating that pain is not the exclusive driver of such behavioral shifts. Unraveling the interaction between the tumor, infiltrating nerves, and the brain is pivotal to developing targeted interventions to alleviate the mental health burdens associated with cancer.
Nuclear magnetic resonance-based metabolomics with machine learning for predicting progression from prediabetes to diabetes
Authors: Li Jiang , Yu Yuefeng , Sun Ying , Fu Yanqi , Shen Wenqi , Cai Lingli , Tan Xiao , Cai Yan , Wang Ningjian , Lu Yingli , Wang Bin
Published: September 2024

Background:

Identification of individuals with prediabetes who are at high risk of developing diabetes allows for precise interventions. We aimed to determine the role of nuclear magnetic resonance (NMR)-based metabolomic signature in predicting the progression from prediabetes to diabetes.

Methods:

This prospective study included 13,489 participants with prediabetes who had metabolomic data from the UK Biobank. Circulating metabolites were quantified via NMR spectroscopy. Cox proportional hazard (CPH) models were performed to estimate the associations between metabolites and diabetes risk. Supporting vector machine, random forest, and extreme gradient boosting were used to select the optimal metabolite panel for prediction. CPH and random survival forest (RSF) models were utilized to validate the predictive ability of the metabolites.

Results:

During a median follow-up of 13.6 years, 2525 participants developed diabetes. After adjusting for covariates, 94 of 168 metabolites were associated with risk of progression to diabetes. A panel of nine metabolites, selected by all three machine-learning algorithms, was found to significantly improve diabetes risk prediction beyond conventional risk factors in the CPH model (area under the receiver-operating characteristic curve, 1 year: 0.823 for risk factors + metabolites vs 0.759 for risk factors, 5 years: 0.830 vs 0.798, 10 years: 0.801 vs 0.776, all p < 0.05). Similar results were observed from the RSF model. Categorization of participants according to the predicted value thresholds revealed distinct cumulative risk of diabetes.

Conclusions:

Our study lends support for use of the metabolite markers to help determine individuals with prediabetes who are at high risk of progressing to diabetes and inform targeted and efficient interventions.

Funding:

Shanghai Municipal Health Commission (2022XD017). Innovative Research Team of High-level Local Universities in Shanghai (SHSMU-ZDCX20212501). Shanghai Municipal Human Resources and Social Security Bureau (2020074). Clinical Research Plan of Shanghai Hospital Development Center (SHDC2020CR4006). Science and Technology Commission of Shanghai Municipality (22015810500).
Intelligent accounting optimization method based on meta-heuristic algorithm and CNN
Authors: Dong Yanrui
Published: September 2024

The evolution of social intelligence has led to the adoption of intelligent accounting practices in enterprises. To enhance the efficiency of enterprise accounting operations and improve the capabilities of accountants, we propose an intelligent accounting optimization approach that integrates meta-heuristic algorithms with convolutional neural networks (CNN). First, we enhance the CNN framework by incorporating document and voucher information into accounting audits, creating a multi-modal feature extraction mechanism. Utilizing these multi-modal accounting features, we then introduce a method for assessing accounting quality, which objectively evaluates financial performance. Finally, we propose an optimization technique based on meta-heuristic principles, combining genetic algorithms with annealing models to improve the accounting system. Experimental results validate our approach, demonstrating an accuracy of 0.943 and a mean average precision (mAP) score of 0.812. This method provides technological support for refining accounting audit mechanisms.