bluuebunny/crossref_metadata_2025 huggingface dataset:
ANÁLISE FATORIAL CONFIRMATÓRIA E EXPLORATÓRIA PARA AS VARIÁVEIS QUE COMPÕEM O ÍNDICE MINEIRO DE VULNERABILIDADE CLIMÁTICA (IMVC)
Authors: Silva Raphael Sússia , Guimarães Ednaldo Carvalho
Published: February 2025

Os indicadores sociais, ambientais e econômicos são frequentemente empregados para caracterizar um setor específico de interesse. A compreensão desses indicadores tem impactos relevantes no desenvolvimento socioeconômico das regiões. Este trabalho tem como objetivo interpretar as variáveis do Índice Mineiro de Vulnerabilidade Climática (IMVC) por meio da análise fatorial, com a intenção de aprofundar a compreensão das vulnerabilidades climáticas nos municípios de Minas Gerais. As variáveis foram obtidas por meio dos dados disponibilizados no site Clima Gerais (https://clima-gerais.meioambiente.mg.gov.br/) e padronizadas para assegurar a eficácia da análise. A Análise Fatorial Confirmatória foi usada para avaliar a adequação do modelo original proposto pelo IMVC, com base nas variáveis e nos construtos teóricos do índice. Já a Análise Fatorial Exploratória (AFE) foi usada para identificar fatores latentes que explicam a maior parte da variância dos dados, agrupando as variáveis com altas correlações e tornando a interpretação possível. Os resultados indicam que a AFE, por meio das análises de componentes principais, foi capaz de reduzir a dimensionalidade dos dados para quatro componentes, explicando uma porcentagem considerável da variância total dos dados mediante um ajuste adequado ao modelo, sugerindo que os componentes extraídos capturam de forma eficaz a estrutura dos dados originais.
EXTREME NATURAL AND CLIMATIC CONDITIONS AS A FACTOR IN THE FORMATION OF THE ARCHITECTURAL ENVIRONMENT
Authors:   South Ural State University, Chelyabinsk, Russia, Tereshina O.B. , Zaletskaya P.O. , Bian Y. , Zhu X.
Published: February 2025

The article considers the factors influencing the principles of design in adverse and extreme climatic conditions. It also ex-amines the historical experience of developing regions with extreme climate, and reveals modern principles of design and construction in such territories. The research focuses on the technologies for improving the comfort and safety of the environment, energy efficiency of buildings, and environmental friendliness of design solutions. The article highlights modern examples of buildings constructed taking into account the effective organization of the environment in extreme natural conditions. It analyses their spatial planning and design solutions. The conclusions concern the peculiarities of the for-mation of the architectural environment in adverse and extreme natural and climatic conditions, which are a factor of technology development, and the search for interesting compositional solutions that contribute to psychological relief and self-improvement of a modern person.
STATISTICAL CHARACTERISTICS OF SNOW LOADS
Authors:   Nosov Magnitogorsk State Technical University, Magnitogorsk, Russia, Emelyanov O.V. , Mukhambetov T.B. ,   Nosov Magnitogorsk State Technical University, Magnitogorsk, Russia, Shuvalov A.N. ,   Moscow State University of Civil Engineering (National Research University), Moscow, Russia
Published: February 2025

When calculating the building structure reliability, it is necessary to have information about the variability of the strength and elastic properties of building materials, the loads acting on the structure, the geometric dimensions of spans and sec-tions, etc. The current loads, including snow loads, have the greatest statistical dispersion and, taking into account the our country climatic conditions, have a significant impact on the stress-strain state of building structures. Snow load statistical characteristics are the result of processing long-term meteorological observations for the snow cover amount in the regions of the country. The lack of information on the snow load statistical characteristics is an objection to practical reliability calculations of building structures. In the load norms SP20.13330.2011 and SP 20.13330.2016, the snow load calculated value is taken as the annual maximum weight of the snow cover, which is exceeded on average once every 25 and 50 years, respectively. The article presents the relationship between the calculated values of snow load in SP 20.13330.2011 and SP 20.13330.2016 and its probabilistic characteristics. It shows the possibility of using Humbel's distribution law for snow load probabilistic modeling with the determination of the characteristics necessary for calculating the reliability and service life of building structures (with a probability of 0.96 and 0.98) depend-ing on the snow area.
TECHNOLOGY FOR THE CONSTRUCTION OF A MULTI-STOREY PREFABRICATED MONOLITHIC FRAME OF A CIVIL BUILDING, THROUGH THE USE OF FIXED REINFORCED CONCRETE BLOCK ROOM FORMWORK IN WINTER
Authors:   South Ural State University, Chelyabinsk, Russia, Khafizov T.M. , Baiburin A.Kh. , Denisov S.E. , Ovchinnikov A.D. , Petrov I.A. , Stepin D.M. , Elisin M.S.
Published: February 2025

The study presents a new construction technology in non-removable reinforced concrete formwork. Long-term practice of monolithic construction in winter allows you to predict the technology of intensification based on a new method of descending concrete. The article shows a variant of the frame of the structure with an underground and ground part, a depth of 50 meters and a height of 150 meters, this variant is prefabricated-monolithic using a non-removable block-room formwork. This option is prefabricated and monolithic using non-removable formwork the size of a block- room. A comparison of well-known prefabricated monolithic and monolithic technologies with technology based on a new method of descending concrete determines the potential of technical solutions in the coming years when choosing a construction technology. The advantage of the new technology lies in the integration of precast and monolithic concrete operations using the advantages of alternative technologies and leveling their shortcomings.
ANALYSIS OF PARTICIPATION AND TASKS OFFERED AT ALL-RUSSIAN OLYMPIADS IN THE DISCIPLINE OF ENGINEERING AND COMPUTER GRAPHICS
Authors:   Tyumen Industrial University, Tyumen, Russia, Boschenko T.V , Desyatov Ya.A.
Published: February 2025

One of the forms of improving the effectiveness of students' training in computer information technology is the Olympiads. Maintenance and support promote the increase of students' involvement in the process of preparation and participation in Olympiads, creating conditions for the formation and development of students' motivation in order to achieve success, search for new solutions. Participation in Olympiads promotes the development and implementation of new computer technologies in the educational process. Students develop such personal qualities as persistence, technical thinking, and creative initiative. Their self-esteem also increases. The paper aims to share the experience of participation in the All-Russian Olympiads, the process of preparation, and analysis of the Olympiad tasks. It also focuses on the activities for promoting students' involvement in the educational process – participation in innovative projects, Olympiads, research work.
As Representações Culturais das Trabalhadoras Domésticas Remuneradas na América Latina Contemporânea
Authors: Maciel Ferraz Lígia
Published: February 2025

Recensão crítica do livro Paid to Care: Domestic workers in contemporary Latin American culture (2023), escrito por Rachel Randall. A obra faz uma análise das representações culturais do trabalho doméstico remunerado na literatura, no cinema e na cultura digital da América Latina contemporânea.
A Distribuição Cinematográfica no Brasil (1907-1915): Recensão do livro O negócio do filme, de Rafael de Luna Freire
Authors: Sampaio Sofia
Published: February 2025

Recensão crítica de O negócio do filme: A distribuição Ccnematográfica no Brasil, 1907–1915, de Rafael de Luna Freire (Rio de Janeiro, 2022).
Introducción al dossier temático: Indisciplinas de los cuerpos, el trabajo de cambiar de piel
Authors: Lambies Josep , De Lucas Gonzalo , De Souza Gillone Ana Daniela
Published: February 2025

Este dossier temático tiene el propósito de estudiar el papel que jugaron las actrices en el cine de dos países, España y Brasil, durante sus respectivos períodos de transición democrática. Alineado con la disciplina de los star studies, el método de análisis propuesto parte, en primera instancia, de detectar tensiones y transgresiones en las gestualidades de las actrices, en sus comportamientos y en sus cuerpos, para verlas aparecer como sujetos activos en la pantalla. Así, siguiendo la línea teórica de autoras como Leslie Adelson o Aurora Morcillo, que instituye que los cuerpos femeninos pueden llegar a reflejar un momento histórico o erigirse en metáfora de una sociedad, este dossier busca establecer correspondencias entre las actrices estudiadas –Sônia Braga, Maria Gladys, Yeda Brown, Amparo Muñoz y María José Cantudo – y el contexto de cambios convulsos y transformaciones en el que se inscriben. Uno de los objetivos perseguidos consiste en determinar en qué medida se puede llegar a reconstruir, a través del estudio de las actrices y de las posibilidades de enunciación que exploran en sus interpretaciones, una alternativa al relato histórico oficial.
Cara Preservasi Fitoplasma dari Jaringan Kacang Tanah Bergejala Sapu untuk Deteksi DNA dengan Teknik PCR
Authors: Pulogu Siska Irhamnawati , Mutaqin Kikin Hamzah , Giyanto Giyanto
Published: February 2025

Witches‘ broom of peanut caused by phytoplasma is a common disease found in Indonesia. Phytoplasma is able to be detected using polymerase chain reaction (PCR) technique. One of important factor which determine the successful of phytoplasma amplification is the DNA availability from fresh tissues. The research was aimed to evaluate some preservation methods of phytoplasma from infected plant samples. The aspects to be evaluated consisted of time (1, 2, 3, and 4 weeks), temperature (-20 °C, 4 °C, and 25 °C), and preservation medium (1X PGB buffer, 3 M NaCl, CTAB buffer, 70% ethanol, non medium, and FTA-card) for storing the fresh phytoplasma infected samples. Good preservation method will optimize the phytoplasma DNA amplification using PCR standard technique followed by nested-PCR. The results showed that preservation of samples at -20 °C, 4 °C, and 25 °C in CTAB buffer was able to maintain the tissue freshness for 4 weeks and was able to provide the DNA of either quality or quantity sufficiently for PCR detection. PCR standard using a primer pair P1/P7 showed that not all of the preserved DNA of phytoplasma were amplified positively. However, standard PCR followed by nested-PCR using primer pair fU5/rU3 was able to increase the DNA detectability. Preserved samples derived from various medium and stored for 4 weeks gave positive results.  This results were in contrary with previous same samples which were detected negatively by standard PCR technique.
A study on the relationship between porosity and dielectric constant of wood considering the change of moisture content and frequency
Authors: Qin Ruixia , Xu Huadong , Guo Jiaxing , Wang Peng , Yang Kang
Published: February 2025

Electromagnetic waves are used in wood inspection and treatment. Three important parameters need to be considered in the application of this method, including moisture content (MC), porosity, and dielectric constant (ε), which affect the effectiveness of application of electromagnetic waves, and these parameters can interact with each other. This study’ elucidated the effect of porosity on the ε of wood at different MCs (absolute dry to saturated) in the frequency (f) range of 1 Hz–107 Hz. The results indicated that the porosity on the ε needs to consider both f and MC. Relationships between porosity and ε of absolute dry wood shows opposite patterns in different f bands. When f ≤ 200 Hz, the porosity was positively correlated with ε. When f > 200 Hz, the porosity was negatively correlated with ε. However, the effect of f on ε with the increased of MC was complicated., Correlations with MC, porosity and ε was not significant when f was low. As f increased, the relationship between MC and ε became linear. The results of this study provide a reference for use of ε to detect wood pore characteristics and MC.
Effect of self-hypnosis on fear and pain of natural childbirth: a randomized controlled trial
Authors: Kamalimanesh Batool , Moradi Maryam , Fathi Mehdi , Afiat Maliheh , Rezazadeh Mahnaz Boroumand , Shakeri Mohammad Taghi
Published: February 2025

Objectives

A clinical trial was conducted to address the trend of high cesarean section rates resulting from maternal fear of childbirth. This trial aimed to investigate the effectiveness of self-hypnosis in mitigating fear and pain during childbirth.

Methods

This study was a parallel, not blinded, randomized controlled trial conducted in 2019 in Mashhad, Iran. Ninety-three nulliparous women were selected by convenience sampling and randomized by random allocation software (4 blocking groups) to either self-hypnosis or control groups. During the clinical trial, both groups received usual care for pregnancy and childbirth. However, the self-hypnosis group also participated in two hypnosis sessions and was given two audio files to practice self-hypnosis at home until delivery. The follow-up period ranged from the 37th week of pregnancy to the postpartum period. Fear of childbirth was assessed at 39 weeks and at cervical dilatation of 8–10 cm, while labor pain was measured at the same stage of labor as the primary outcomes between two groups. Data were analyzed using SPSS 16, applying the Independent sample t-test, Mann–Whitney U test, and Chi-square test. A p-value of less than 0.05 was considered statistically significant.

Results

Thirty women in the self-hypnosis group, aged 24.96±5.42, and 33 women in the control group, aged 23.63±4.68, completed the study. The average scores of fear of childbirth during pregnancy at 39 weeks (self-hypnosis: 46.46±14.53, control: 73.18±17.91), during the active phase of labor at cervical dilatation of 8–10 cm (self-hypnosis: 40.80±17.37, control: 75.12±19.40), and labor pain at cervical dilatation of 8–10 cm (self-hypnosis: 83.03±16.43, control: 95.36±10.36) were significantly lower in the self-hypnosis group compared to the control group (p<0.001 for all).

Conclusions

Our findings suggest that self-hypnosis could be a more effective intervention than usual care alone for reducing fear and pain during natural childbirth in nulliparous women.
Retrospective assessment of hepatic involvement in patients with inherited metabolism disorders: nine-year single-center experience
Authors: Bayramova Samira , Koç Yekedüz Merve , Köse Engin , Eminoğlu Fatma Tuba
Published: February 2025

Objectives

This study aimed to identify clinical, laboratory, and radiological features that could serve as red flags for diagnosing inherited metabolic disorders (IMDs) with hepatic involvement in childhood.

Methods

We retrospectively reviewed the medical records of 1,237 children from a pediatric metabolism department, with suspected or diagnosed IMDs. Patients with hepatic involvement were divided into two groups: Group 1 (diagnosed with IMDs) and Group 2 (undiagnosed). Demographic, clinical, laboratory, and radiological data were compared between the groups.

Results

Hepatic involvement was observed in 415 patients (33.5 %), with 206 (49.2 %) diagnosed with IMDs. Group 1 had higher rates of consanguineous marriage and affected siblings. Complex molecule disorders (20.4 %), mitochondrial (16.0 %), and lipid metabolism disorders (16.0 %) were the most common IMDs. Dysmorphic findings were more frequent in Group 1 (28.2 vs. 16.3 %, p=0.004), while diarrhea was less common (4.4 vs. 12.0 %, p=0.005). Ammonia and lactate levels were higher in Group 1 (p<0.001 and p=0.032, respectively). Hepatomegaly was more frequent in Group 1 (53.3 vs. 22.6 %, p<0.001). Pathological abdominal ultrasonography was the only significant multivariate predictor (OR: 89.377, p=0.026). Overall survival was 87.7 %, with no difference between groups.

Conclusions

Consanguineous marriage, affected siblings, dysmorphic findings, absence of diarrhea, and pathological abdominal USG are key predictors of IMDs in hepatic involvement cases.
On a theorem of Nathanson on Diophantine approximation
Authors: Hančl Jaroslav , Nguyen Tho Phuoc
Published: February 2025

In 1974, M. B. Nathanson proved that every irrational number α represented by a simple continued fraction with infinitely many elements greater than or equal to k, is approximable by an infinite number of rational numbers p/q satisfying

|

α
−
p

/

q

|

<
1

/

(

k
2

+
4

q
2

)
.

$|\alpha-p/q|<1/(\sqrt{k^2+4}q^2).$

In this paper, we refine this result.
Novel generalized tempered fractional integral inequalities for convexity property and applications
Authors: Kashuri Artion , Munir Arslan , Budak Hüseyin , Hezenci Fatih
Published: February 2025

Inequalities involving fractional operators have also been an active area of research. These inequalities play a crucial role in establishing bounds, estimates, and stability conditions for solutions to fractional integrals. In this paper, firstly we established two new identities for the case of differentiable convex functions using generalized tempered fractional integral operators. By utilizing these identities, some novel inequalities like Simpson-type, Bullen-type, and trapezoidal-type are proved for differentiable s-convex functions. Additionally, from the obtained results, several special cases of the known results for different choices of parameters are recaptured. Finally, some applications to q-digamma and modified Bessel functions are given.
Exploring dynamical features like bifurcation assessment, sensitivity visualization, and solitary wave solutions of the integrable Akbota equation
Authors: Chou Dean , Sagher Azad Ali , Asjad Muhammad Imran , Hamed Yasser Salah
Published: February 2025

The Akbota equation (AE), as a Heisenberg ferromagnetic-type equation, can be extremely valuable in the study of curve and surface geometry. In this study, we employ the well-known two analytical techniques, the modified Khater method and the new sub-equation approach, to construct the solitary wave solution of AE. Transform the partial differential equation into an ordinary differential equation using the wave transformation. The graphical visualization of select wave solutions is carried out using Wolfram Mathematica software. By utilizing appropriate parametric values across various wave velocities, this process unveils the intricate internal structures and provides a comprehensive understanding of wave behavior. The visual representations are rendered in 3D, 2D, and contour surfaces, capturing a range of solitonic phenomena. These include multiple kink solitons, flat kink, kink-peakon, kink solitons, and singular kink solitons, offering detailed insights into the complex dynamics of the system under study. Newly obtained soliton solutions are compared with available soliton solutions in the literature. The new results indicate that these obtained solutions can be a part of completing the family of solutions, and the considered methods are effective, simple, and easy to use. For qualitative assessment, convert the ordinary differential into a dynamical system by using the Galilean transformation to conduct the sensitivity visualization and bifurcation assessment along with phase portraits and chaos analysis of the considered model. Bifurcation analysis is crucial in soliton dynamics, as it influences the behavior and characteristics of solitons in various systems, with the results presented through phase portraits. Sensitivity visualization illustrates how parametric values affect the system’s behavior. The solutions obtained have broad applications in surface geometry and electromagnetism theory. The aim of this study is to enhance the understanding of complex nonlinear dynamics and their relevance in curve and surface geometry.
When God was a Woman꞉ From the Phocaean Cult of Athena to Parmenides’ Ontology
Authors: Montagnino Marco
Published: February 2025

The aim of this article is to present a new hermeneutic perspective on Parmenides’ theology, which, it is argued, will also have consequences for our understanding of his ontology. The following interrelated hypotheses are presented for consideration: first, that the anonymous goddess introduced by Parmenides in the proem of his poem is identical to the Phocaean poliadic goddess of Elea, Athena; second, that she is the personification of Parmenides’ tò eón.
Age-related behavioural abnormalities in C57BL/6.KOR–Apoe
shl mice
Authors: Ueno Hiroshi , Takahashi Yu , Mori Sachiko , Kitano Eriko , Murakami Shinji , Wani Kenta , Miyazaki Tetsuji , Matsumoto Yosuke , Okamoto Motoi , Ishihara Takeshi
Published: February 2025

Spontaneously hyperlipidaemic (Apoeshl) mice were discovered in 1999 as mice lacking apolipoprotein E (ApoE) owing to a mutation in the Apoe gene. However, age-related behavioural changes in commercially available Apoeshl mice have not yet been clarified. The behavioural abnormalities of ApoE-deficient mice, which are genetically modified mice artificially deficient in ApoE, have been investigated in detail, and it has been reported that they can serve as a model of Alzheimer’s disease (AD). To understand whether Apoeshl mice can also serve as a murine model of AD, it is necessary to investigate age-related behavioural abnormalities in Apoeshl mice. In this study, we conducted a series of behavioural experiments on 7- and 11-month-old Apoeshl mice to investigate the behavioural abnormalities associated with ageing in Apoeshl mice. In this study, 7-month-old Apoeshl mice showed decreased body weight and grip strength compared to age-matched wild-type mice. In the open field test, 7-month-old Apoeshl mice showed increased anxiety-like behaviour compared to wild-type mice, whereas 11-month-old Apoeshl mice showed decreased anxiety-like behaviour. Moreover, Apoeshl mice aged 7 and 11 months had increased serum cholesterol levels. These results indicate that the behaviour of Apoeshl mice changes with age. However, 11-month-old Apoeshl mice did not show a decline in cognitive function or memory ability similar to murine models of AD. Our findings indicate that Apoeshl mice can be used to investigate the function of ApoE in the central nervous system.
Uncanny Resemblances – Prov 9 as an Introduction to Proverbial Thinking
Authors: Ehmer Yannik
Published: February 2025

This article suggests that Prov 9 serves as an introduction to Prov 10:1–22:16, »dramatizing« it as competing banquets of Wisdom and Folly. Proverbial knowledge allows to discern between the invitations of the two voices. It enables the student of wisdom to navigate a life amidst ambiguities and uncanniness. Proverbial thinking teaches a phenomenological and critical hermeneutics that takes response-ability––i.e. the ability to respond––seriously. The uneducated person (פְּתִי) must learn to which call they should respond. Folly/chaos is therefore an integral part of Wisdom/order.
Forme et fonction de courts récits miraculeux sur Élisée
Authors: Rückl Jan
Published: February 2025

S’inspirant de l’étude classique de V.J. Propp Morphologie du conte, l’article décrit la morphologie abstraite des courts récits miraculeux sur Élisée dans 2 Rois, et procède ensuite à une analyse plus détaillée de certaines de leurs caractéristiques particulières. Malgré leur couleur populaire, ces légendes sont profondément marquées par l’image de la prophétie qui s’est imposée parmi les lettrés judéens aux époques exilique et perse. Il semble donc que ces textes n’aient pas seulement été insérés dans les Rois à l’époque postexilique, mais qu’ils aient aussi été composés à cette époque, même s’ils peuvent contenir quelques motifs anciens.
Identifying Pannag, an Ancient Product of Israel
Authors: Eichler Raanan
Published: February 2025

The hapax legomenon פַּנַּג
pannag is mentioned in Ezekiel as an export of the land of Israel to the international market in Tyre (Ezek 27:17). It has been interpreted in wildly different ways, with the dominant view now being that it is a kind of baked good or flour. A few scholars have noted Greek πάνακες »allheal« as an apparent cognate, but they have not realized its significance. It is argued here that Hebrew pannag and its Akkadian cognate pinigu both derive from Greek πάνακες and denote a medicinal product of the Ferula (giant fennel) plant or of a related genus. Accordingly, pannag should be translated »allheal.«
The Willow Project and Environmental Justice: Analyzing U.S. Energy Policy’s Impact on Sensitive Ecosystems and Local Communities
Authors: Pai Shriya , Hall Caitlyn A.
Published: February 2025

In this article, we examine the Willow Project as a significant case study in oil and gas development within Alaska’s National Petroleum Reserve, through the lens of the broader challenges of balancing energy development with environmental stewardship. We highlight the project’s implications on biodiversity, climate change, and local communities, particularly the Indigenous populations who depend on these lands for their livelihoods. The case of Willow serves as a microcosm for the national debate over energy priorities in the context of climate goals and environmental justice. Through our analysis, we highlight the contradictions between the stated environmental and climate commitments of the U.S. administration and the realities of ongoing fossil fuel projects. We discuss legislative and regulatory responses to these challenges, including recent changes aimed at protecting ecologically sensitive areas from drilling. However, we argue that more comprehensive reforms are necessary to truly align U.S. energy policy with climate resilience and social equity. In assessing the Willow Project, we also compare the proposed economic benefits, such as job creation and energy security, with the expected costs from environmental degradation and cultural disruption, emphasizing the need to weigh immediate economic gains against long-term ecological and societal impacts. By engaging with this case study, readers will gain a nuanced understanding of the complexities involved in managing natural resource extraction in sensitive ecological zones. They will also be able to appreciate the importance of integrating scientific research, policy analysis, and community feedback in crafting energy policies that support both national energy needs and environmental sustainability.
Navigating the transition: assessing continuity and loss in endocrinology care
Authors: Nursoy Hatice , Hocaoglu Erhan , Yasar Muge , Mercan Saridas Filiz , Karatoprak Kadircan , Gul Ozen Oz , Cander Soner , Ersoy Canan , Ezirmik Elif , Denkboy Ongen Yasemin , Tarim Omer , Erturk Erdinc , Eren Erdal
Published: February 2025

Background: Transition describes preparing children with chronic illnesses for adult healthcare and gradually transferring their care, starting late adolescence. Joint meetings and visits are recommended during this process. This study examines an 8-year transition experience in our clinic, focusing on the differences between adult and pediatric endocrinology practices and the rates of loss to follow-up in specific disease groups.

Methods: Three hundred thirty-five patients evaluated in transition meetings were included. The frequency of visits one year before transition, during the first and second years after transition, the number of patients lost to follow-up, and disease groups were analyzed.

Results: Among the patients discussed in the transition meetings, 56.3% participated in joint visits. Post-transition, 82.5% of patients continued their follow-up care, while 17.5% were lost to follow-up. There was a statistically significant difference in the number of visits before and after the first year of transition (p=0.000).

Conclusion: To increase adaptation during the transition, informing patients and families about the process at every visit after late adolescence is beneficial. Moreover, scheduling joint visits on flexible dates and increasing the number of joint visits per patient could substantially enhance patient participation and follow-up rates. We observed that patient follow-up frequency was higher in pediatric endocrinology due to differences in pediatric and internal medicine practices.
Prolonged Inhalation Sedation in the Intensive Care Unit Using the AnaConDa Device (Cases Report)
Authors: Achkasov Alexey P. , Cherpakov Rostislav A. , Khusainov Shamil Zh. , Kulabukhov Vladimir V. , Yartsev Petr A. , Levikov Dmitry I. , Kuznetsov Sergey N. , Shabanov Aslan K.
Published: February 2025

This report describes two clinical cases involving prolonged inhalation sedation using the AnaConDa device in the ICU. Both patients achieved and maintained adequate sedation levels throughout the treatment period. No significant adverse cardiovascular effects were observed.
Az intracameralis cefuroxim toxicitásáról
Authors: Elekes Ágnes , Vámosi Péter
Published: February 2025

Napjainkban a legnagyobb számban végzett műtéti beavatkozás a világon a
szürkehályog-műtét. A pontos műlencsetervezésnek és a kifinomult
phacoemulsificatiós technikának köszönhetően a cataractaműtét eredményei
kiválóak. Nemzetközi és hazai szakmai irányelvben rögzített kötelező lépés a
műtét végén elülső csarnokba injektálandó antibiotikum, az endophthalmitis
megelőzésére használt 0,1 ml 1%-os cefuroxim. Az előírtnál nagyobb mennyiségben
beadott vagy rosszul hígított gyógyszer mind a szem elülső csarnokában, mind a
szemfenéken súlyos, maradandó szövődményeket okozhat. Az előírt adagolás mellett
ritkán előfordulhatnak kevéssé ismert elváltozások, melyek azonban helyi
terápiára jól reagálnak. Közleményünkben irodalmi összefoglalót kívánunk adni az
intracameralis cefuroximról, annak potenciális toxicitásáról egy saját eset
ismertetése kapcsán. Orv Hetil. 2025; 166(8): 301–306.
Calcium carbonate-based biodegradable composites as an alternative material to industrial plastics
Authors: Ho Nathan , Huang Yi , Chung Eun Ji
Published: February 2025

Persistent pollution caused by conventional plastics poses significant risks to marine ecosystems and human health. Thus, there is a need for the development of biocompatible and biodegradable materials that mimic the properties of plastics that are also safe for environmental and public health. To address this, we engineered a plastic substitute by integrating calcium carbonate (CC), an abundant mineral naturally found in seashells, into poly (1,8-octanediol-co-citrate) (POC), a synthetic biodegradable elastomer already used as the binder of FDA-approved orthopedic fixation devices containing calcium minerals. We hypothesized that POC-CC is a biocompatible plastic substitute that can degrade in marine environments while maintaining sufficient strength for industrial applications. To test this, POC-CC was synthesized with varying CC concentrations (0, 15, 30 wt%). Weight degradation rate in ocean water, pH of ocean water after long-term incubation, elastic modulus, and the morphology of POC-CC using SEM was evaluated over 6 months. Our results show the degradation rate increases with increased POC content, and the addition of CC maintains the pH of ocean water. Additionally, to evaluate biocompatibility, Scenedesmus sp. algae was incubated with the POC-CC supernatant after incubation with simulated ocean water for six months. High cell viability was found, confirming the biocompatibility of POC-CC with marine microorganisms. Lastly, a model can holder was made with POC-CC to demonstrate its proof-of-concept as an alternative plastic material. In sum, we demonstrate POC-CC as a new material and the feasibility of its use as a biodegradable plastic alternative.

Graphical abstract
Systematic Study of Silicon Carbide Detectors and Beam Current Transformer Signals for UHDR Single Electron Pulse Monitoring
Authors: Okpuwe C. , Milluzzo G. , Coves D. , Delaviere T. , Del Sarto D. , De Napoli M. , Di Martino F. , Felici G. , Lanzanò L. , Masturzo L. , Pensavalle J. , Touzain E. , Camarda M. , Romano F.
Published: February 2025

The use of ultra-high dose rate beams (UHDR) (> 40 Gy/s) for radiotherapy, despite its advantage of exhibiting the FLASH effect that improves the sparing of healthy tissues, faces challenges in dosimetry and beam monitoring since standard dosimeters like the ionization chamber experience saturation effects at such high dose rates. Silicon carbide (SiC) detectors have recently been demonstrated to be dose-rate independent with low-energy pulsed electron beams up to an instantaneous dose rate of 5.5 MGy/s, and has emerged as a reliable alternative technology for dosimetry in FLASH-RT. This study explored the suitability of using the SiC detector for measuring intra-pulse instantaneous dose rates, which are necessary for monitoring fluctuations within the pulse of UHDR pulsed electron beams. The experiments reported were conducted using UHDR electron beams accelerated at 9 MeV by an ElectronFlash linac and using varying different beam parameters, such as the beam current (i.e., different dose per pulse) and pulse width settings. The temporal single pulse shape signals were measured with a 10 µm thick, 4.5 mm2 area SiC detector for different configurations and compared with a well-characterized AC current transformer (ACCT) (which served as the standard monitoring system of the accelerator), and with a second ACCT placed at the same location as the SiC detector (i.e., after the applicator at the irradiation point). The results show a high level of agreement between the signals of the SiC detector and ACCT placed after the applicator at around the irradiation point. This underscores the potential of the SiC detector and the ACCT to be used for monitoring instantaneous dose rates within a pulse. Furthermore, since use of the SiC detector and ACCT are based on different physical principles, they can provide complementary beam information. A combination of the two has the potential to provide insight about a variety of variables of interest for UHDR beams. However, some discrepancies were observed when comparing the SiC signals with the ACCT installed in the LINAC, which increased linearly with decreasing dose per pulse. Further studies are required to better understand these observations.
Occupation-based practice in a tertiary hospital setting: occupational therapists' perceptions and experiences.
Authors: Hess-April Lucia , Dennis, Lynique , Ganas Nicolette , Phiri Lungelo , Phoshoko Pumza
Published: February 2025

Occupation-based practice is an important feature of occupational therapy. There is however limited research regarding occupational therapists' experiences with occupation-based practice. This study aimed to explore occupational therapists' perceptions and experiences regarding occupation-based practice in a tertiary hospital setting in the Western Cape, South Africa. An explorative and descriptive research design within a qualitative research approach was utilised. Purposive sampling allowed the selection of fourt participants with a minimum of 2 years practice experience. Semi-structured interviews were conducted to gain an understanding of how they perceived and implemented occupation-based practice. Data were analysed using thematic analysis. Four themes emerged: occupation-based practice expresses professional identity; occupation-based practice necessitates relevance; constraints to occupation-based practice; and facilitators of occupation-based practice. The findings revealed that the participants' perceived the implementation of occupation-based practice as an expression of their professional identity and that in adopting an occupation-based approach they perceived their roles as diverse and transformational. It was however highlighted that the nature of the service context posed several constraints that influenced the implementation of occupation-based practice. Thus, occupational therapists may need to generate practice-based evidence to advocate for the service conditions necessary to implement occupation-based practice and deliver relevant occupational therapy services.Â Key words: Occupation; occupation-based practice; tertiary hospitals; qualitative research
The effects of rehabilitation education for village health volunteers on walking speed and upper-extremity function in stroke survivors in Thailand
Authors: Chinchai Pisak , Khamwong Peanchai
Published: February 2025

Introduction: Stroke can cause long-term disabilities to survivors. Rehabilitation is an on-going process and should, ideally, be provided to these people in their homes. This study aimed to investigate the effect that rehabilitation education provided to village health volunteers (VHVs) would have on walking speed and upper extremity (UE) function in stroke survivors who stay at home in Thailand.Methods: Participants were recruited by purposive sampling, which included 27 stroke survivors from four municipalities in Chiang Mai and Lamphun provinces. The measuring instruments used were the Ten-Meter Walk Test and the UE motor domain of the Fugl-Meyer Assessment. Researchers presented a 7-hour rehabilitation education programme to VHVs, who then made weekly 1-hour visits to the homes of stroke survivors to implement the rehabilitation programme over eight weeks. Data were collected within seven days before and then again after the 8-week programme. Results: Descriptive statistics and the paired t-test were applied to analyse the data. Results showed that the participants usedsignificantly less walking time from pre-test ( X =34.73Â±8.48) to post-test ( X =32.18Â±9.32) (p<0.05). However, the score of UEfunction at pre-test ( X =36.81Â±9.59) was not significantly different from that at post-test ( X =37.26Â±9.67).Conclusion: The findings suggest that trained VHVs can be part of the rehabilitation team and contribute to improved functional performance for disabled stroke survivors, particularly in developing countries
SANGRAMENTO UTERINO ANORMAL DEVIDO ANTICOAGULAÇÃO E SEU DESAFIO TERAPÊUTICO: UMA REVISÃO BIBLIOGRÁFICA NARRATIVA
Authors: Medeiros Isabela Ramos Araújo de , Abrão Feres , Mattera Fernando Otavio Pires , Toreto Barbara Nascimento , Bueno Carlos Eduardo , Bueno Patrícia Cincotto dos Santos , Migliaccio Alana Hordane , Oliveira Nathalia Cristian Ferreira de
Published: February 2025

O sangramento uterino anormal (SUA) é uma das principais afecções ginecológicas que levam as mulheres na menacme a procurarem atendimento, podendo também trazer grande impacto na qualidade de vida dessas pacientes, acarretando em enfermidades e internações. Para o esclarecimento da causa do sangramento, devemos proceder a uma investigação visando primeiramente dividir as causas entre estruturais e não estruturais, avançando em análise com exames complementares, laboratorialmente e de imagem. Dentre as causas não estruturais, além de anovulação, causas endometriais, idiopáticas e malignas, temos a coagulação. A coagulação é uma causa pouco abordada para o sangramento uterino anormal, apesar de estar sendo mais frequente devido a necessidade de anticoagulação dessas pacientes por diversos motivos, como por exemplo trombofilias, cardiopatias, válvulas cardíacas ou imobilização. Na vigência de anticoagulação, temos a possibilidade de evolução com sangramento uterino aumentado, possuindo um avanço crônico, levando a implicações a longo prazo e de forma progressiva, como a anemia ferropriva acentuada, por depleção de reserva da paciente de forma contínua. Atrelado a essa condição, as pacientes tendem a evoluir com repercussão em atividade laborais, com frequente e cíclico absenteísmo. Por se tratar de uma causa frequente e com importantes sequelas, desenvolvimento crônico e possibilidade terapêutica, entende-se a importância de um melhor debate e uma ampliação nas viabilidades terapêuticas, encaminhando-se muito além da conduta cirúrgica.
Why Antibiotics cannot be the Main Treatment for Acute Pneumonia
Authors: Igor Klepikov
Published: February 2025

It has been known for almost two millennia that the inflammatory process of an organ disrupts its function, which determines the specificity of the clinical picture of the disease. Antibiotics can only have a selective antimicrobial effect but do not directly affect the mechanisms of the inflammatory process. The ability to suppress one of the initial factors of inflammation creates more favorable conditions for the body to fight inflammation. The first successes of antibiotics created the illusion of their decisive role in the treatment of inflammatory processes. Over time, under the influence of antibiotics, the etiology of pneumonia changed, and pathogens that are not included in the spectrum of action of antimicrobial drugs became leaders. This situation already now determines the urgent need for an urgent radical revision of the strategy in the treatment of pneumonia.
After-LCM (Laser-Capture Microdissection) procedure v1
Authors: M Basudan Aisha , Basudan Aisha
Published: February 2025

This protocol describes after-LCM (Laser-Capture Microdissection) procedure.
OncoMark v1
Authors: Priyadarshi Shreyansh
Published: February 2025

This protocol details the methodology for developing and validating OncoMark, a neural multi-task learning framework designed to predict cancer hallmark activity from transcriptomic data. It covers synthetic data generation from single-cell transcriptomics, hallmark annotation, model architecture, training, validation, and statistical analyses.
Study of hydrodynamic regularities in a layer of wet solid municipal waste during its dehydration
Authors:   Ivanovo State Power Engineering University, Kolibaba O.B. , Kozlova M.V. ,   Ivanovo State Power Engineering University, Garyaev A.B. ,   National Research University “Moscow Power Engineering Institute”, Morozov Yu.V. ,   Ivanovo State Power Engineering University
Published: February 2025

Thermal destruction is one of the effective methods of treatment of municipal solid waste (MSW) is. Various installations are used for thermal processing, including shaft furnaces, which are distinguished by high reliability and simplicity of design. The waste being processed moves in the furnace body under the action of gravity, passing through drying and pyrolysis zones and undergoing continuous heat treatment. In the drying zone, the MSW layer is heated and dehydrated due to heat exchange with the gas flow from the underlying pyrolysis zone. A disadvantage of shaft furnaces is poor gas permeability of the layer in the drying zone, caused by the stickiness of the raw materials. It leads to uneven passage of the gas flow through the porous layer. Therefore, flow fluid dynamics of the layer should be organized in such a way as to take this feature into account. In this regard, it is relevant to study the hydraulic resistance of the MSW layer, which is influenced by a number of factors, such as the structure and humidity of the layer, as well as the speed of the drying agent. Computational and experimental research methods have been used to study hydrodynamic regularities in the layer of wet MSW during their dehydration. The authors have established the dependences on the coefficient of hydraulic resistance on the raw material moisture content and the filtration rate of the drying agent based on the results of experimental studies of the hydrodynamics of a layer of wet MSW during its drying. A formula has been proposed to calculate the pressure drop in a layer of waste considering the porosity of the MSW layer. It has been experimentally established that the coefficient of hydraulic resistance decreases unevenly with decreasing humidity during the drying process. In the zone of high humidity (40–89 %) a slight decrease in resistance is observed, the nature of the dependence is close to linear. Then the resistance drops sharply, the nonlinearity of the dependence increases. The results obtained can be used to select the operating modes of shaft furnaces for thermal processing of MSW.
Study of voltage unbalance in low-voltage electrical networks with microgeneration systems
Authors:   Kaliningrad State Technical University, Kugucheva D.K. , Kharitonov M.S. ,   Kaliningrad State Technical University
Published: February 2025

The issues of studying the influence of microgeneration facilities based on renewable energy sources on the quality indicators of electric power are not widely covered in national studies. However, due to the task set by the Government of the Russian Federation to increase the number of renewable energy sources used by active consumers, the relevance of the study is to determine the features of the influence of microgeneration facilities connected to low-voltage distribution electric networks on voltage unbalance to determine further development paths for this energy sector. The purpose of the study is to design a model of a low-voltage distribution electric network with microgeneration facilities and conduct a computational experiment to assess the influence of microgeneration facilities based on renewable energy sources on voltage unbalance, to determine the ways to improve the quality parameters of electric power associated with voltage unbalance. The study uses a simulation approach, applying a method of mathematical modeling implemented using software complexes NEPLAN and Load Profile Generator. The authors have identified the peculiarities of the impact of microgeneration units on positive voltage deviations and have conducted sensitivity analysis of nodes in the modeled network section based on voltage change criteria. The voltage unbalance coefficients in the negative sequence for the most sensitive network node at various levels of microgeneration unit penetration and different ways of their connection and control are determined. The study also has identified the characteristics of voltage change at each phase with different methods of controlling and connecting microgeneration units. The deployment of microgeneration objects affects positive deviations in voltage and voltage unbalance. The main factors of this influence are the following: the method of connection and control of the microgeneration object, voltage unbalance before the deployment of microgeneration objects, the relationship between the instantaneous powers of the consumer load and the microgeneration object, the sensitivity of nodes to changes in voltage criteria, depending on the electrical distance of microgeneration objects from the main substation, feeder parameters, and load. It has been established that the most effective solution to the asymmetry problem is to redistribute the power provided by the microgeneration object among the phases of the power grid.