bluuebunny/crossref_metadata_2025 huggingface dataset:
Development of Effervescent-assisted Liquid Phase Microextraction using 1-dodecanol for Determination of Ketoprofen Drug in Water
Authors: Wan Mohd Khalik Wan Mohd Afiq
Published: June 2020

A rapid and straightforward method based on effervescent-assisted dispersive liquid-liquid microextraction combined with high-performance liquid chromatography-ultraviolet (HPLC-UV) detection for preconcentration of ketoprofen in water samples was developed. The extraction efficiency of ketoprofen drug was investigated using 23 central composite design. The values of optimum extraction condition were set as 300 µL volume of 1-dodecanol, three pieces of tablets, and 30°C extraction temperature. The runtime was conducted in less than 6 min using a non-polar C18 column and an isocratic mobile phase (acetonitrile: water of 40:60 (v/v)) at a controlled flow rate of 1 mL min-1. A good linear response was achieved in the range of 0.01–0.50 µg mL-1 (R2 > 0.990). Detection and quantification limits were calculated at 0.001 and 0.004 µg mL-1, respectively. The average recoveries at three spiking concentration levels were within the range of 85%–108% with RSD < 10% (n = 3). Real sample analysis was fortified using gel and standard solutions, and the calculated values were close to the actual values at 0.059 µg mL-1 (KET gel, initial concentration 0.075 µg mL-1) and 4.49 µg mL-1 (standard solution, initial concentration 5 µg mL-1), respectively.
Los videojuegos como mundos ludoficcionales críticos: el caso de la crisis política española en el ocio digital móvil (2008-2015)
Authors: Planells de la Maza Antonio José
Published: June 2020

La presente investigación tiene por objetivo analizar la capacidad crítico-discursiva del videojuego persuasivo contemporáneo. Se han analizado los diez títulos para móvil más populares cuya temática central es la crisis en España desde 2008 a 2015, mediante una metodología basada en la teoría de los mundos posibles y la retórica procedimental. Los resultados muestran cómo la parodia se usa como principal catalizador lúdico en el tratamiento de los hechos denunciados a nivel social, que son, a su vez, los elementos que conforman las mecánicas y dinámicas de la experiencia de juego.
Metode Learning Management System (LMS) Idu Untuk Mendukung Kegiatan Belajar Mengajar MIT Pada Perguruan Tinggi Raharja
Authors: Rahardja Untung , Aini Qurotul , Zuliana Siti Ria
Published: June 2020

Currently the entire field has been supported by technology, especially the world of education in the learning process to determine the quality of a college graduate. In the world of education Perguruan Tinggi Raharja has implemented iLearning learning methods to achieve the learning objectives. Graduate students are given learning experiences using methods iLearning the learning process using the media Ten Pillar IT iLearning (TPi). But the learning process is not running properly and still undeniably versatile use paper as a method of learning in general, Therefore at this time to achieve the learning objectives very effectively implement methods Learning Management System (LMS) iDu which can be accessed online anytime and anywhere easily. The purpose of this study to determine measure the success of the learning process at MIT class that still use manual systems in the learning process . This study uses a quantitative approach with descriptive correlational survey method . Sample collection techniques in this study was based on the results of the student survey MIT classes . Data collector by using questionnaires and documentation . Results from the study showed that the better level the results of the learning process to use iDu’s system where students could complete the learning easily anywhere and anytime . In this journal Identified there are three (3) the problems faced and the solutions given are by utilizing campus Learning Management System (LSM) iDu. Do 8 (eight) literature review as a post-graduate study materials. And there were 13 (thirteen) advantages and 1 (one) shortcomings of this study. The implementation is done in the course MasteringInformation Technology (MIT). This study is expected to improve the quality of graduates from graduate students in Perguruan Tinggi Raharja.
Pengaruh Perbandingan Runner Terhadap Performa Turbin Vertikal Bertingkat Dua
Authors: Sunardi Ade , Hanun Yunan
Published: June 2020

Wind energy is an alternative energy resources that abundant, enviromentally friendly and potential to be develop. The Utilization of wind energy can be applied at wind turbine. Ratio of vane amount as a runner was the variable that use on this research such as . Research use natural windfor 24 hours and data became fluctuatif. Data test obtain ratio runner 6:10 have greatest rotational speed, which is 373 rpm and mean rotational speed is 83.42 rpm. Runner ratio 6:12 have lowest rotational speed 291 rpm and mean rotational speed is 20.13
Penerapan Zpreneur Dengan Tehnik Gamifikasi Berupa Transfer Armo Untuk Meningkatkan Kualitas Pembelajaran
Authors: Aini Qurotul , Pratama Danny , Heriyani Novita
Published: June 2020

Along with the development of technology that the sooner make the College began to improve competitiveness in terms of technology and information education. Rapid improvement from year to year make Raharja College want to always innovate, be creative and make an innovation that will benefit the entire Personal Raharja. Many ways in which to improve the quality of forcibly lectures in the learning process, techniques gamifikasi judged capable of being an effort to enhance the quality of the lectures in the learning. ZPreneur is able to realize the effort, because the ZPreneur apply the technique of gamifikasi with either Armo (AirzonE-Mall Money) are able to make student/i don't feel saturated and give change in the learning activities. The College currently Raharja already apply the learning to use the concept of Gamifikasithrough a website ZPreneur. Plus the design Viewboard Armo became complete as all user embodied in all viewboard armo and will motivate the user to always be no. 1 in viewboar armo.
Analisa Pengaruh Kemampuan Kerja Pegawai Dan Komunikasi Antar Pribadi Terhadap Kualitas Pelayanan Perusahaan PT. Indosat tbk
Authors: Sanni M. Ifran , Friandi Sendy Zul , Rifai Danang
Published: June 2020

Answering the challenges of the business world of telecommunications services with the sharpening of competition, Indosat need to do to improve the quality of service. For that we need a sober assessment of the factors that have an influence on the quality of the service itself. Suspected of employees working ability and interpersonal communication can affect the quality of service at the company experiment was conducted with the aim of proving allegations that an employee working ability and interpersonal communication together affect the quality of care in Indosat. From the results of data processing can be in the know that individually and the two independent variables have a relationshipand influence equally strong on the quality of service (r X1 = 0.621 and r x2 = 0.670) Collectively variable Job Skills Employees and Communication Between Personal Associated very strong with quality service on (R = 0.853) and by the coefficient of determination of 72.8% affect test results significantly with T test and F test proved significant at 95% confidence level, it can be concluded that: Alleged ability Employee Work and Inter-Personal Communication together effect on the quality of service at PT Indosat Tbk. Positive and significant effect can be received.
Multimedia Audio Visual And Broadcasting Bagian Detik TV PT. Agranet Multicitra Siberkom Jakarta Selatan
Authors: Suryadi Jendi , Arief Muhammad , Winoto Winoto
Published: June 2020

The rapid development of technology in the current era of globalization makes a handful of people need to get more information, in order to add insight. No doubt the need for information becomes a necessity. News is an information about the occurrence of an event or event. Its development through radio broadcasting, print media, television broadcasting and online media. Online news broadcasting is a package that must be packaged well and good for people who watch it get the latest and actual information. An online news broadcasting package includes activities to be Reporter, Editing related to production and packaging in News delivery in PT. AGRANET MULTICITRA SIBERKOM (detikcom).
Pengaruh Penerapan Manajemen Mutu ISO 9001:2008 Dan Kepemimpinan Terhadap Kualitas Pelayanan SMK Negeri 2 Kabupaten Tangerang
Authors: Rifai Danang , Fallah Syamsul , Purwasari Mira
Published: June 2020

This research entitled the influence of the implementation of ISO 9001:2008 quality management on leadership and service quality in SMK Negeri 2 Kabupaten Tangerang. The formulation of this research problem is whether there is influence of the implementation of ISO 9001: 2008 and principal leadership on the quality of service in SMK Negeri 2 Tangerang Regency. While tujuaannya is wanted to know the effect of the implementation of ISO 9001: 2008 and teacher performance on service quality in SMK Negeri 2 Kabupaten Tangerang. This research used survey method with correlation technique, sample size 350 people, student research object, teacher and employee of SMK Negeri 2 Kabupaten Tangerang. The result of this research is that there is a significant effect of quality management of ISO 9001: 2008 and principal leadership together towards the quality of service in SMK Negeri 2 Kabupaten Tangerang. This is evidenced by (sig) of 0.000 <0.05 and Fcount of 62.233. There is a significant effect of quality management of ISO 9001: 2008 on the quality of service in SMK Negeri 2 Kabupaten Tangerang. This is evidenced by the value of Sig = 0.000 <0.05 and tcount = 5.933. There is a significant influence of Headmaster's leadership on the quality of service in SMK Negeri 2 Kabupaten Tangerang. And proved by the value of Sig = 0.001 <0.05 and tcount = 3.396.
Media Berbentuk Katalog PT. Polymindo Permata Kota Tangerang Penunjang Informasi Dan Promosi
Authors: Budiarto Mukti , Arief Muhammad
Published: June 2020

PT Polymindo Permata Tangerang which is new and still use the spoken and written media, exhibitions, events and websites but the less effective media to inform and introduce PT Polymindo Permata Tangerang city, PT. Polymindo jewel of the Tangerang city requires media catalog to support various activities such as informing the public at large. On the concept of there stages of Rough Layouts, Konferenship Layouts, Layout So. In order to produce an interesting catalogue of media design and quality used applications supporting Adobe Illustrator CC, then from it because the author does the design needs of media catalog.
Manajemen Sistem Monitoring Pembayaran Hutang Pembelian Untuk Estimasi Pengeluaran Sebagai Pendukung Keputusan
Authors: Saputro Janu Ilham , Martono Dedi , Sunariah Siti
Published: June 2020

The development of information technology has recently experienced such rapid development, this is followed by the development of information media that continues to grow. Companies are always required to follow this development in order to improve service quality and company performance. At present, various companies are required to pay taxes according to the rules that have been determined as a form of the company's obligation to the state. Problems that often occur in the company are uncontrolled po and tax invoices, so that often there is an overpayment of tax debt from what should be, and this causes delays in decision making, so that financial planning in payment of purchase debt. To be able to overcome this problem, a computerized system is needed to monitor the purchase debt calculation system as a decision support for expenditure estimation. To be able to realize this, it takes several design steps by analyzing the procedures that are running, building a system design with usecase diagrams, activity diagrams, squen diagrams and class diagram designs as a form of data storage center which can then be processed automatically so that it becomes the basis for decision making. Then implemented by building a web-based system that can be used in the company. The expected benefits are the creation of a system that is able to run effectively and efficiently, as well as being able to print reports quickly and accurately, so as to reduce problems that often occur in the company.
Desain Majalah Penunjang Promosi Dan Informasi Pada AFC Indonesia
Authors: Andriyanto Andriyanto , Arfa Arfa , Kurnia Virhaz
Published: June 2020

The need for information to all areas is progressing so rapidly, many parties such as companies, institutions or organizations approach through forms of media print, film or electronic media. The approach of using the means of supporting the media performed in order to obtain the value of effectiveness in achieving the desired targets on a promotion that is used. As is the case at AFC Indonesia, a company that carries out functions and provide services. In order for the community or customer and are interested in purchasing products in Indonesia, the need for AFC media visual design process to help promote the company to the public. In accordance with the results of the interview, the company says that the current AFC Indonesia in disseminating and promoting the use of new banners, and billboards, yet also the existence of means of promotion that encapsulates the entire profile The company.
Desain Majalah Penunjang Promosi Dan Informasi Pada SMK Karya Bangsa Kota Tangerang
Authors: Sugiarto Dian , Suhadi Suhadi
Published: June 2020

The development of information technology is very advanced. Information Plays an important role, with information makes it easir for people to find information they want, information can be obtained through print and electronic media, especially print media shaped magazine design in this case the SMK Karya Bangsa The City Of Tangerang very requires media magazines to easily load the entire information. Therefore the author made a magazine media at the SMK Karya Bangsa The City Of Tangerang so that the information easily known and the promotion system becomes more effective and creative is expected to be improve the image and improve marketing at school. Methodology used in this study include problem analysis methods, methods data collection, design analysis methods and design concept methods include : media planning, message planning and visual planing. In order to produce a design the good media for this magazine is using design support software like Adobe Photoshop CS5 and Adobe InDesign CS5, therefore the authors do the design mgazine media summarized in this chapter with the title “ DESIGN VISUAL COMUNICATION MEDIA FROM OF MAGAZINE DESIGN AS SUPPORTING PROMOTION AND INFORMATION ON SMK KARYA BANGSA THE CITY OF TANGERANG”.
Perancangan Sistem Pembayaran SPP Pada SMK Islam Iqro Pasar Kemis
Authors: Roza Yuni , Suci Rahayu Rais Nurlaila , Jati Aditya Risdiarto
Published: June 2020

Islamic Vocational School Iqro Pasar kemis has the vision, mission and goals of graduates who have faith, piety and morality as well as competent in mastery of science and technology. But now Islamic vocational high school Iqro Pasar Kemis still use conventional way in conducting SPP transactions that is by noting the payment card and payment data manually recorded on the book. This causes the payment process to take a long time and a large errorrate, but it also inhibits the speed of data access and information delivery to be too late. With the existing problems then the researchers propose the design of payment systems to facilitate the process of payment of SPP. The research method used is SWOT analysis, for design method using Unified Modeling Language (UML), and system testing method using Blackbox Testing. This research is expected to provide easiness in the implementation of school fee payment activities as well as easiness in the delivery of school fee payment information to students and parents of students.
Implementasi Sistem Informasi Pembayaran SPP Berbasis Web (Studi Kasus : SMK Arrahman Tangerang)
Authors: Azizah Nur , Warid Mohamad , Hidayatulloh Arif
Published: June 2020

SPP payments still often experience problems such as data collection and the payment information process that has been used so far is still simple (semicomputerization) using only Microsoft Excel in inputting reports, therefore there are often problems in making reports for students in making spp payments required. precise and accurate so that it has not been able to produce a web-based SPP payment information system needed. In the current technological era, it is necessary to innovate the use of technology in the world of education to assist the administration of school finances so that the data collection and information process of Payments run effectively and efficiently. In this journal, we will discuss about designing a web-based SPP payment information system. This design aims to assist the finance department in recording SPP payments. The research method used is the SDLC type Waterfall method. This application helps the finance department in recording SPP payments.
Peter Koslowski’s Ethics and Economics or Ethical Economy: A Framework for a research agenda in business ethics
Authors: Rendtorff Jacob Dahl
Published: June 2020

This paper presents the concept of ethical economy (Wirtschaftsethik) and the relation between ethics and economics on the basis of the work of the German ethical economist Peter Koslowski. The concept of ethical economy includes three levels: micro, meso and macro levels; and it also deals with the philosophical analysis of the ethical foundations of the economy. After the discussion of these elements of the ethical economy, the paper presents some possible research topics for a research agenda about economic ethics or ethical economy.
Review Study on the Accumulation and Release of Trace Metal Elements on Aluminum Containing Sediments in Drinking Water Distribution System
Authors: ZHANG Xiaoni , MENG Jinghua , CHEN Li , ZUO Huanhuan , WANG Wendong
Published: June 2020

Accumulation and releasing of trace metal elements on aluminum containing sediments of inner drinking water pipe is discussed, as studied from five variations effecting: raw water quality, chemical reagents, solution pH and drinking water flow condition . In order to decrease the release of trace metal elements, and to ensure the pipe operation and human safety, water quality adjustment is suggested to avoid aluminum containing sediments formation in drinking distribution system. The maximum amounts of accumulation of common trace metal elements are given. Future trends of development in this field are also proposed.
İran Eşitlikçi Kadın Hareketleri Perspektifinden “Kadın Meselesi”nin Açıklanması
Authors: EL-HILO Müştak
Published: June 2020

İran’daki “feminizm” kavramı konusunda henüz görüş birliğine varılmaması ve eşitlikçilerin birçoğunun kendisini feminist olarak tanımlamamaları sebebiyle bu çalışmanın adı “İran’da Eşitlikçi Kadın Hareketleri” olarak belirlenmiş; “eylem” kavramı ise Bloomer’in tanımına bağlı kalınarak değerlendirilmiştir. Yaşamlarının pek çok alanında maruz kaldıkları gelenekten beslenen cinsiyetçi ayrımcılıkla mücadele eden İran halkı, eşitlikçiler olarak adlandırılmaktadır. Bu çalışma ıslahat dönemi olarak bilinen; kadın hareketlerinin had safhaya ulaştığı Muhammed Hatemi’nin cumhurbaşkanlığı (1997-2005) yıllarını kapsamaktadır. Eşitlikçiler; kadın ve erkek arasındaki cinsiyetçi yaklaşımları ve cinsiyetleri göz önünde bulundurularak onlara sunulan çeşitli hak, özgürlük ve imkânları eşitsizlik olarak kabul etmektedir. Bu durumun makul çerçeve dışında kaldığı, toplumun tümüne zarar verdiği düşünülmekte ve bunun acilen düzeltilmesi talep edilmektedir. Eşitlikçilere göre eşitsizliği ortaya çıkaran etmenlerin yanı sıra bunun gelecek nesillere aktarılarak sürdürülmesini sağlayan dinamikler bulunmaktadır. Onlara göre yozlaşmış dinî inanışlar, aile yapısı, eğitim sistemi, kitle iletişim araçları, politika, iş gücü piyasası ve kadına yönelik şiddet toplumda eşitsizliğin ortaya çıkarılmasında ana sebeptir. Bu makalede tanımlayıcı ve analitik araştırma yöntemlerinden faydalanılmıştır. Kadın hareketinin anlaşılabilmesi için bu konudaki görüşler kısaca aktarılmış ve analiz edilmiş; yazılı ve elektronik kaynaklara başvurulmuştur.
Relation between plasma lipids and relapse of idiopathic nephrotic syndrome in children
Authors: Kabir Md Humayan , Akter Khandaker Rokshana , Dey Probhat Ranjan , Mia Mohammad Abdul Hai , Chowdhury Md Ziaur Rahman , Chowdhury Minakshi , Hossain Mohammad Zakir
Published: June 2020

Background: Nephrotic syndrome (NS) is one of the most common renal diseases in children. It is a chronicchildhood disorder with a course of relapse and remission. Hyperlipidemia is a constant feature (95% cases)of minimal change nephrotic syndrome (MCNS) having serum cholesterol >250 mg/dl. Both increased synthesisand decreased clearance of lipoproteins may contribute to the hyperlipoproteinemia which frequently complicatesthe NS. Persistent hyperlipidemia can lead to relapse of NS which is a potential risk factor for progression ofglomerular injury. Persistent hyperlipidemia and frequent relapse of NS are further responsible forcardiovascular disease and progressive glomerular damage leading to renal failure. This study was done todetermine relationship between plasma lipids and relapse of idiopathic NS in children.

Methods: This prospective study was carried out from July 2015 to June 2017 at the Department of Paediatricsin Sylhet MAG Osmani Medical College Hospital. Patients with the diagnosis of NS fulfilling the inclusioncriteria were included in this study purposively. A total of 50 children were included into this study. Theprimary end point was to determine plasma lipids level in children having idiopathic NS at acute phase, inremission and at 6 months after completion of treatment. The secondary end point was to evaluate the relationshipbetween persistent hyperlipidemia in remission phase and relapse of NS.

Results: Among 50 children with clinical diagnosis of NS, 35 were first episode and 15 were in relapse cases.Among the first episode NS cases serum lipids level were decreased significantly during remission but HDLwas increased, whereas in relapse cases even during remission serum lipids level were significantly higher.After six months of follow up, out of 50 patients 28 patients had persistent remission and 22 patients hadrelapsed. The relationship between plasma lipids level and the incidence of relapse showed that acute lipidfraction levels were not risk factor in relapsing NS. Only the triglyceride level during remission was a riskfactor in relapsing NS (p<0.035) with OR 5.4 and 95% CI [1.06, 25.4].

Conclusion: Persistent hypertriglyceridemia and hypercholesterolemia in remission phase is a risk factor forrelapse of idiopathic NS in children.

Birdem Med J 2020; 10(2): 97-102
Biyokömür ve organik gübre uygulamalarının soğan bitkisinin gelişimi ve kimyasal gübreden yararlanma oranına etkileri
Authors: MOUNİROU Moustapha Maman , KAYA Emre Can , OUEDRAOGO Abdoul-rasmane , DEMİR Köksal , GÜNEŞ Aydın , İNAL Ali
Published: June 2020

Bu çalışmanın amacı, farklı inorganik gübre (%100, %50 ve %0 İG) düzeylerinde keçi gübresi (KG, 5 t ha-1) ve bundan elde edilen biyokömür (BK, 10 t ha-1) uygulamalarının ayrı ayrı ve birlikte uygulanmasının soğan bitkisinin gelişimi ile inorganik gübreden (İG) yararlanma düzeylerine etkisini belirlemiştir. Bu amaçla; 2018 ilkbaharında taze soğan (Metan 88) bitkisi yetiştirilmiş ve deneme sonunda ortalama bitki yaş ve kuru ağırlığı, toplam verim, N, P, K, Ca, Mg, Fe, Zn, Cu ve Mn konsantrasyonları belirlenmiştir. Deneme alanında, %100 İG, BK ve BK+KG uygulamalarıyla N içeriği, İG uygulanmayan bitkilerde tüm organik gübre uygulamalarıyla P içeriği, BK ve BK+KG uygulamalarıyla K, Ca ve Mg içeriği artış göstermiştir. BK uygulaması tek başına bitki Fe ve Cu içeriklerini önemli düzeyde azaltmış, İG uygulamaları Zn içeriğini artırmıştır. BK ve BK+KG uygulamaları bitki Mn içeriğini önemli düzeyde artırmıştır. Sonuç olarak BK ve KG’nin birlikte uygulamasının verim ve verim öğeleri açısından daha uygun olduğu belirlenmiştir.
Organik ve geleneksel çay tarımı uygulamalarının bazı toprak kalite parametreleri ile mikro besin elementi elverişliliği üzerine etkileri
Authors: ÖZDEMİR Nutullah , ÖNAL Tevhide , KOP DURMUŞ Tebessüm
Published: June 2020

Bu araştırma, Rize ili koşullarında organik ve geleneksel çay tarımı uygulamalarının, bazı toprak kalite parametreleri (tekstür, toprak reaksiyonu, elektriksel iletkenlik, organik madde, katyon değişim kapasitesi) ve mikro besin elementlerinin elverişlilikleri üzerine etkilerini belirlemek üzere yürütülmüştür. Araştırmaya ait toprak örnekleri, Rize ili Çayeli ilçesi Senoz Vadisi’nde belirlenen iki koordinat arasında kalan hat üzerinde bulunan parsellerden (0-20cm) alınmıştır. Toprak örnekleri üzerinde yapılan analiz ve değerlendirmeler sonucun da ölçülen toprak kalite parametreleri (tekstür, toprak reaksiyonu, elektriksel iletkenlik, organik madde, katyon değişim kapasitesi) üzerinde, uygulama ve rakım farkının etkisi olduğu saptanmıştır. Daha düşük rakıma sahip geleneksel tarım uygulamalarının yapıldığı yerlerde organik madde miktarı ortalama %8,75 belirlenirken, daha yüksek rakıma sahip organik tarım uygulamalarının yapıldığı yerlerde organik madde miktarı ortalama %5,76 olarak belirlenmiştir. Gerek organik ve gerekse geleneksel tarım uygulamaların yapıldığı parsellerde Fe, Cu, Zn ve Mn içeriklerinin yeterli düzeyde bulundukları tespit edilmiştir.
Vejetasyon indis değerleri ile şeker pancarı yaprak azot içeriğinin izlenmesi
Authors: DEDEOĞLU Mert
Published: June 2020

Yaprak azot (N) içeriği fotosentez ve bitki metabolizmasındaki kritik rolleri nedeniyle tarımsal uygulamalar için en önemli değişkenlerdendir. Bu çalışmada Sentinel 2A uydu görüntülerinden türetilen Redge -NDVI değerleri ile üç farklı vejetasyon dönemi için şeker pancarı bitkisinde yaprak %N içeriklerinin parsel bazlı olarak ilişkilendirilmesi amaçlanmıştır. Çalışma Konya-Çumra bölgesinde seçilen 26 farklı çiftçi arazisinden Mayıs-Haziran-Temmuz 2019 tarihlerinde alınan yaprak örnekleri ve belirtilen tarihlere yakın temin edilen uydu görüntüleri kullanılarak yürütülmüştür. Araştırma ile vejetatif gelişim ve kök oluşum evresinde yaprak %N içerikleri ve Redge – NDVI değerleri arasında tatmin edici doğruluk katsayıları (0.74 ≤ r2 ≤ 0.83) elde edilmiş, ancak şeker pancarı kök büyüme dönemi içerisinde ilişkinin azaldığı (r2
SENAM ERGONOMIK UNTUK MENGATASI HIPERGLIKEMI PADA LANSIA DENGAN DM DI PANTI WREDA HARAPAN IBU SEMARANG
Authors: Nurmalika Lilik , Prasetiya Chandra Hadi
Published: June 2020

Diabetes melitus adalah ketika tubuh tidak dapat menghasilkan insulin sehingga kelebihan kadar glukosa didalam tubuh yang melebihi batas normal (hiperglikemia). Diabetes melitus jika tidak ditangani dengan tepat dapat menimbulkan berbagai komplikasi dalam tubuh. Tujuan studi kasus ini menyusun resume asuhan keperawatan (pengkajian, diagnosa keperawatan, perencanaan, implementasi dan evaluasi). Dalam pemberian senam ergonomik untuk mengatasi hiperglikemi pada lansia dengan DM. Subjek dari penelitian ini adalah dua klien dengan kriteria inklusi dalam studi kasus ini adalah pasien DM dimana kadar glukosa darah yang tinggi diatas 200 mg/dl sebanyak 2 klien, klien mengeluh sering buang air kecil. Lansia yang berusia ± 60 tahun, lansia yang tidak mengalami luka terutama dibagian kaki, lansia yang tidak mengalami gangguan mobilisasi, lansia kooperatif. Hasil studi menunjukkan bahwa ke 2 responden didapatkan hasil klien 1 dan 2 yang telah dilakukan senam ergonomik mengalami penurunan terhadap hiperglikemi. Disimpulkan bahwa senam ergonomik dapat mengatasi hiperglikemi pada lansia dengan DM.
STUDI DESKRIPTIF PEMANFAATAN POSYANDU LANSIA
Authors: Juwariyah Siti , Jona Resa Nirmala
Published: June 2020

Peningkatan  jumlah warga  berusia lanjut hingga 4 kali dalam kurun waktu 35 tahun, sejak tahun 1990 hingga 2025. Pada tahun 2020, perkiraan penduduk lanjut usia di Indonesia mencapai 25,5 juta jiwa. Pertambahan usia menyebutkan kemampuan fisik dan mental. Aspek kesehatan pada lansia lebih diperhatikan mengingat kondisi anatomi dan fungsi organ-organ tubuhnya sudah tidak sempurna seperti ketika berusia muda. Perawatan dan perhatian terhadap diri sendiri semakin menurun kualitas dan kuantitasnya. Sehingga perlunya peningkatan kualitas hidup lansia. Tujuan dari penelitian ini adalah untuk mengetahui pemanfaatan posyandu lansia oleh lansia. Metode penelian ini menggunakan metode penelitian kuantitatif deskriptif. Subjek penelitian berjumlah 50 lansia yang hadir di posyandu lansia. Data penelitian diperoleh dengan mengunakan dokumentasi dan kuesioner dukungan keluarga. Tehnik pengumpulan data dengan menggunakan simple random sampling. Analisis data pada penelitian ini menggunakan statistik deskriptif. Secara umum pemanfaatanposyandu lansia tidak sepenuhnya dimanfaatkan dengan baik oleh lansia. Hal ini terjadi karena lansia menganggap bahwa sakit itu biasa dan akan periksa kalo memang benar-benar sudah sangat mengganggu. Berdasarkan observasi bahwa peran keluarga dan lingkungan sangat penting karena lansia sangat membutuhkan dukungan. Ketidakhadiran lansia ke posyandu lansia disebabkan oleh kondisi fisik yang terjadi pada lansiaa seperti sedang sakit, tidak adanya anggota keluarga yang mengantarkan ke posyandu.
Capacity for Seeding and Spreading of Argyrophilic Grain Disease in a Wild-Type Murine Model; Comparisons With Primary Age-Related Tauopathy
Authors: Ferrer Isidro , Andrés-Benito Pol , Sala-Jarque Julia , Gil Vanessa , del Rio José Antonio
Published: June 2020

Argyrophilic grain disease (AGD) is a common 4R-tauopathy, causing or contributing to cognitive impairment in the elderly. AGD is characterized neuropathologically by pre-tangles in neurons, dendritic swellings called grains, threads, thorn-shaped astrocytes, and coiled bodies in oligodendrocytes in the limbic system. AGD has a characteristic pattern progressively involving the entorhinal cortex, amygdala, hippocampus, dentate gyrus, presubiculum, subiculum, hypothalamic nuclei, temporal cortex, and neocortex and brainstem, thus suggesting that argyrophilic grain pathology is a natural model of tau propagation. One series of WT mice was unilaterally inoculated in the hippocampus with sarkosyl-insoluble and sarkosyl-soluble fractions from “pure” AGD at the age of 3 or 7/12 months and killed 3 or 7 months later. Abnormal hyper-phosphorylated tau deposits were found in ipsilateral hippocampal neurons, grains (dots) in the hippocampus, and threads, dots and coiled bodies in the fimbria, as well as the ipsilateral and contralateral corpus callosum. The extension of lesions was wider in animals surviving 7 months compared with those surviving 3 months. Astrocytic inclusions were not observed at any time. Tau deposits were mainly composed of 4Rtau, but also 3Rtau. For comparative purposes, another series of WT mice was inoculated with sarkosyl-insoluble fractions from primary age-related tauopathy (PART), a pure neuronal neurofibrillary tangle 3Rtau + 4Rtau tauopathy involving the deep temporal cortex and limbic system. Abnormal hyper-phosphorylated tau deposits were found in neurons in the ipsilateral hippocampus, coiled bodies and threads in the fimbria, and the ipsilateral and contralateral corpus callosum, which extended with time along the anterior-posterior axis and distant regions such as hypothalamic nuclei and nuclei of the septum when comparing mice surviving 7 months with mice surviving 3 months. Astrocytic inclusions were not observed. Tau deposits were mainly composed of 4Rtau and 3Rtau. These results show the capacity for seeding and spreading of AGD tau and PART tau in the brain of WT mouse, and suggest that characteristics of host tau, in addition to those of inoculated tau, are key to identifying commonalities and differences between human tauopathies and corresponding murine models.
Study of the Mechanics and Micro-Structure of Wheat Straw Returned to Soil in Relation to Different Tillage Methods
Authors: Wang Yanpeng , Abbas Adnan , Wang Xiaochan , Yang Sijun , Odhiambo Morice R. O. , Ding Qishuo , Sun Guoxiang , Shi Yinyan
Published: June 2020

A field experiment was conducted to study the effects of different tillage methods, and their interaction on the dynamic changes of straw decomposition rate, mechanical properties, and micro-structure of the stalk. A nylon mesh bag technique was used. An obvious change was observed in the decomposition rate of straw, and its mechanical, and micro-structural properties. The decomposition rate of straw was increased in all tillage treatments. Specifically, it increased consistently in conventional and dry rotary tillage, and sharply in wet rotary tillage. Furthermore, for all tillage, the mechanical properties like shear and bending strengths decreased sharply while compressive strength first decreased linearly and then increased, whereas the micro-structure of wheat straw showed a fluctuating trend, i.e., it changed neither regularly nor consistently over time. Moreover, the micro-structure of the stalk explained the morphological changes to the straw that returned to the field, which may impact the mechanical properties. However, these changes could not explain the degradation trend of straw directly. The findings of the study could be used as a theoretical reference for the design of tillage and harvesting machinery keeping in view soil solidification and compaction dynamics.
Effect of Bacterial Strains Isolated from Stored Shiitake (Lentinula edodes) on Mushroom Biodeterioration and Mycelial Growth
Authors: Tejedor-Calvo Eva , García-Barreda Sergi , Sánchez Sergio , Marco Pedro
Published: June 2020

Shiitake (Lentinula edodes) is a fungus that attracts the attention of consumers and researchers due to its flavour and bioactive compounds with biological activities. However, it swiftly loses quality because of its short shelf life. The present work evaluated the shelf life of cultivated shiitake carpophores with a weekly monitoring of the physico-chemical, microbiological, and sensory parameters under three different storage conditions. To establish the mycopathogenicity of fruitbody-inhabiting bacterial microbiota, 48 strains were isolated from shiitake throughout its storage time and subsequently inoculated on cap cuticles and slices. Additionally, an antibiogram of these bacterial strains against shiitake mycelium was performed. Shiitake had a total microbial load of 5 log cfu/g, composed mainly of Pseudomonas genus, followed by Enterobacteriaceae family, and moulds and yeasts. Among the 48 bacterial strains identified, 18 belonged to the Enterobacteriaceae family and 21 to the Pseudomonas genus. The biodeterioration capacity of the isolated strains increased throughout the conservation period, with slices being more damaged than cap cuticles. We observed a mycopathogenic behaviour of Burkholderia sp., Ewingella americana, Serratia sp., Microbacterium sp. and Rahnella sp. strains, although only the latter highly inhibited shiitake vegetative mycelium growth.
Plant Performance and Metabolomic Profile of Loquat in Response to Mycorrhizal Inoculation, Armillaria mellea and Their Interaction
Authors: Camprubi Amelia , Solari Jimena , Bonini Paolo , Garcia-Figueres Francesc , Colosimo Fabrizio , Cirino Veronica , Lucini Luigi , Calvet Cinta
Published: June 2020

A greenhouse experiment was established with loquat plants to investigate the role of arbuscular mycorrhizal fungi (AMF) in the control of the white root rot fungus Armillaria mellea and to determine the changes produced in the plant metabolome. Plants inoculated with two AMF, Rhizoglomus irregulare and a native AMF isolate from loquat soils, were infected with Armillaria. Although mycorrhization failed to control the Armillaria root infection, the increased growth of infected plants following inoculation with the native mycorrhizal isolate suggests an initial tolerance towards Armillaria. Overall, metabolomics allowed highlighting the molecular basis of the improved plant growth in the presence of Armillaria following AMF colonization. In this regard, a wide and diverse metabolic response was involved in the initial tolerance to the pathogen. The AMF-mediated elicitation altered the hormone balance and modulated the production of reactive oxygen species (mainly via the reduction of chlorophyll intermediates), possibly interfering with the reactive oxygen species (ROS) signaling cascade. A complex modulation of fucose, ADP-glucose and UDP-glucose, as well as the down-accumulation of lipids and fatty acids, were observed in Armillaria-infected plants following AMF colonization. Nonetheless, secondary metabolites directly involved in plant defense, such as DIMBOA and conjugated isoflavone phytoalexins, were also involved in the AMF-mediated plant response to infection.
Genetics of Lifetime Reproductive Performance in Italian Heavy Draught Horse Mares
Authors: Mantovani Roberto , Folla Fabio , Pigozzi Giuseppe , Tsuruta Shogo , Sartori Cristina
Published: June 2020

Our aims were to find a phenotypic variable to express mares’ lifetime reproductive performance after 6 breeding seasons (BS) in Italian Heavy Draught Horse breed (IHDH), and to estimate its heritability. At first, 1487 mares in a training dataset were used to implement and validate a set of predictive coefficients (LFR-C) or equations (LFR-E) to estimate a lifetime foaling rate (LFR) after 6 BS, i.e., the number of foals generated divided by the opportunities to do so. Then, 3033 mares in a dataset with at least 3 registered BS, was used to estimate LFR for mares with 3, 4, or 5 registered RS. This dataset contained actual (n = 1950) and estimated (n = 1443) LFR, obtained by LFR-C, and LFR-E; Arcsine transformation of LFR-C and LFR-E were also analyzed in single trait animal models to estimate heritability. Overall, the LFR showed a moderate but significant genetic variation, and the heritability of the trait was high (0.24) considering it is a fitness trait. The arcsine transformation of LFR did not show any improvement of heritability. The present study indicates the possible use of a linear LFR variable for breeding purposes in IHDH breed considering both complete and incomplete reproductive careers.
Genomic Tools for the Conservation and Genetic Improvement of a Highly Fragmented Breed—The Ramo Grande Cattle from the Azores
Authors: Amaral Andreia J. , Pavão Ana L. , Gama Luis T.
Published: June 2020

Ramo Grande is a local cattle breed raised in the archipelago of Azores, with a small and dispersed census, where inbreeding control is of utmost importance. A single nucleotide polymorphism (SNP) Beadchip array was used to assess inbreeding, by analysis of genomic regions harboring contiguous homozygous genotypes named runs of homozygosity (ROH), and to estimate past effective population size by analysis of linkage disequilibrium (LD). Genetic markers associated with production traits were also investigated, exploiting the unique genetic and adaptation features of this breed. A total of 639 ROH with length >4 Mb were identified, with mean length of 14.96 Mb. The mean genomic inbreeding was 0.09, and long segments of ROH were common, indicating recent inbred matings. The LD pattern indicates a large effective population size, suggesting the inflow of exotic germplasm in the past. The genome-wide association study identified novel markers significantly affecting longevity, age at first calving and direct genetic effects on calf weight. These results provide the first evidence of the association of longevity with genes related with DNA recognition and repair, and the association of age at first calving with aquaporin proteins, which are known to have a crucial role in reproduction.
Omega-3 Alpha-Linolenic Fatty Acid Affects the Level of Telomere Binding Protein TRF1 in Porcine Skeletal Muscle
Authors: Ogłuszka Magdalena , te Pas Marinus F. W. , Poławska Ewa , Nawrocka Agata , Stepanow Kamila , Pierzchała Mariusz
Published: June 2020

Omega-3 fatty acids are health-promoting nutrients that contribute to the amelioration of age-related diseases. Recent studies have reported the role of these fatty acids in the aging process, explicitly impacting telomere biology. The shelterin protein complex, located at the extremities of chromosomes, ensures telomere protection and length regulation. Here, we analyzed the impact of dietary omega-3 alpha-linolenic fatty acid from linseed oil on skeletal muscle telomere biology using an animal model of female pigs. Fifteen animals were supplemented with linseed oil for nine weeks and an equal number of individuals were fed with a control diet. Linseed-oil-supplemented animals showed an increased level of alpha-linolenic acid in skeletal muscles compared to control animals. There was no difference between groups in the telomere length measured in leukocytes and muscles. However, muscles of the linseed-oil-supplemented pigs showed lower levels of the shelterin TRF1 protein compared to the control group. Our results suggest that omega-3 linolenic acid counteracts the elevation of TRF1 levels, which increase with age and due to the presence of reactive oxygen species in muscle. The observed effect may be due to attenuation of oxidative stress.
Potential Causes of Increased Vocalisation in Elderly Cats with Cognitive Dysfunction Syndrome as Assessed by Their Owners
Authors: Černá Petra , Gardiner Hannah , Sordo Lorena , Tørnqvist-Johnsen Camilla , Gunn-Moore Danièlle
Published: June 2020

The objectives of this study were to explore owner perception of the causes of increased vocalisation in cats diagnosed with cognitive dysfunction syndrome (CDS) and consider what impact this vocalisation may have on the cat’s household. Owners of cats diagnosed with CDS that presented with increased vocalisation were invited to complete an online survey. The survey consisted of 28 questions including the cat’s signalment, its medical history, and questions pertaining to the owner’s perception of what motivated their cat´s increased vocalisation. This was determined by looking at the cat’s behaviour when vocalising, where it was looking when it was vocalising, and if the vocalisation stopped when the owner interacted with it, e.g., petting or feeding it. The owners were also asked how stressful they found their cat’s vocalisation. There were 37 responses. The majority of owners reported that the main cause of their cat’s vocalisation appeared to be disorientation (40.5%) or attention seeking (40.5%). Seeking a resource such as food was reported in 16.2%, and pain was perceived to be the cause in only 2.7% of cats. However, the majority of owners (64.8%) believed there was >1 cause of their cat’s increased vocalisation. Importantly, when owners were asked how stressful they found their cat’s increased vocalisation, 40.5% scored ≥3 (where 1 = not stressful; 5 = significantly stressful). This study provides novel insight into owner perception of feline CDS, as well as potential causes for increased vocalisation; this will allow veterinarians to better advise owners on how to manage their cat with CDS.
Genetic Characterization of Native Donkey (Equus asinus) Populations of Turkey Using Microsatellite Markers
Authors: Yatkın Selen , Özdil Fulya , Özkan Ünal Emel , Genç Serdar , Kaplan Selçuk , Gürcan Eser Kemal , Arat Sezen , Soysal Mehmet İhsan
Published: June 2020

This study presents the first insights to the genetic diversity and structure of the Turkish donkey populations. The primary objectives were to detect the main structural features of Turkish donkeys by microsatellite markers. A panel of 17 microsatellite markers was applied for genotyping 314 donkeys from 16 locations of Turkey. One hundred and forty-two alleles were identified and the number of alleles per locus ranged from 4 to 12. The highest number of alleles was observed in AHT05 (12) and the lowest in ASB02 and HTG06 (4), while ASB17 was monomorphic. The mean HO in the Turkish donkey was estimated to be 0.677, while mean HE was 0.675. The polymorphic information content (PIC) was calculated for each locus and ranged from 0.36 (locus ASB02) to 0.98 (locus AHT05), which has the highest number of alleles per locus in the present study. The average PIC in our populations was 0.696. The average coefficient of gene differentiation (GST) over the 17 loci was 0.020 ± 0.037 (p < 0.01). The GST values for single loci ranged from −0.004 for LEX54 to 0.162 for COR082. Nei’s gene diversity index (Ht) for loci ranged from 0.445 (ASB02) to 0.890 (AHT05), with an average of 0.696. A Bayesian clustering method, the Structure software, was used for clustering algorithms of multi-locus genotypes to identify the population structure and the pattern of admixture within the populations. When the number of ancestral populations varied from K = 1 to 20, the largest change in the log of the likelihood function (ΔK) was when K = 2. The results for K = 2 indicate a clear separation between Clade I (KIR, CAT, KAR, MAR, SAN) and Clade II (MAL, MER, TOK, KAS, KUT, KON, ISP, ANT, MUG, AYD and KAH) populations.
Structural Modifications of 3-Triazeneindoles and Their Increased Activity Against Mycobacterium tuberculosis
Authors: Majorov Konstantin B. , Nikonenko Boris V. , Ivanov Pavel Yu. , Telegina Lyudmila N. , Apt Alexander S. , Velezheva Valeria S.
Published: June 2020

We synthesized 100 novel indole-based compounds with polyaza-functionalities, including 3-triazeneindoles, and tested their activity in vitro against laboratory M. tuberculosis H37Rv and clinical izoniazid-resistant CN-40 isolates, using gross and fine titration approaches. Here we present a few 3-triazeneindoles with the highest anti-mycobacterial activity. Introduction of short lipid tails into the 3-triazeneindole core additionally increased their activity against mycobacteria engulfed by murine macrophages. We also demonstrate that the compound TU112, one of the most active in our previous study, being not bioavailable after administration in mice per os, manifests prominent anti-mycobacterial activity after intravenous or aerosol delivery, as assessed by the mouse serum and lung supernatant titration assays.
Evaluation of Using Natural Fillers to Improve Moisture Damage Resistance and the Use of Pull-Off Tensile Test in Determining Moisture Damage Resistance in Asphalt Mixture
Authors: Rachabut Kroekphon , Chaturabong Preeda
Published: June 2020

Moisture is one of the critical failures affecting asphalt pavement. It has been recently found that moisture created by rainwater and undrained water deteriorate the bonding interface between asphalt mastic and aggregate. Using different mineral fillers can lead to different moisture resistance in the same mix design. Nowadays, waste natural materials allow agriculturists to receive more income by recycling in many industries. In this study, the researchers adopted bagasse and coconut peat grinding into very fine particle passing through the sieve number 200 (0.075 mm) to replace the mineral fillers. Although the indirect tensile strength (ITS) test is commonly used for evaluating the moisture damage resistance of hot-mix asphalt (HMA) in a laboratory, there are some shortcomings in using this test, such as costly, heavy and indirect equipment. Another potential test that is likely to be more advantageous than the ITS test for evaluating the moisture damage resistance is the pull-off tensile strength (POTS) test. However, it is typically measured on a concrete surface, and no results using an asphalt mixture have been reported. The objectives in this study were to investigate the effects of waste natural fillers in asphalt mixture on adhesive bonding caused by moisture, and to determine whether the POTS test is a potential method in measuring moisture damage resistance in a laboratory. Results showed that the tensile strength ratios (TSR) of asphalt mixture with bagasse and coconut peat fillers are approximately equivalent to those with mineral fillers. Results also showed that asphalt mixtures with bagasse and coconut peat fillers can effectively prevent the moisture damage resistance. In addition, with the preliminary result, it was found that the POTS test showed a very good R square (R2) for a relation of TSR with the ITS test. As a result, the POTS can be a valid tool of quantifying moisture damage resistance with better simulating to field behavior, lower cost of equipment, and light weight.