bluuebunny/crossref_metadata_2025 huggingface dataset:
Contribuições de teorias do ensino da arte para a docência de História da Arte no nível superior: reflexões sobre experiências
Authors:   Universidade Estadual Paulista ", Demarchi Rita de Cássia ,   Júlio de Mesquita Filho"
Published: September 2021

Este trabalho busca compartilhar reflexões e metodologias advindas da docência da disciplina História da Arte junto a alunos de cursos nas áreas de Arte e Desenho Industrial em uma faculdade particular da cidade de São Paulo, nos anos de 2002 a 2005. A grande maioria dos alunos demonstrou inicialmente pouca familiaridade com a História da Arte e a principal expectativa em relação ao curso era a de aquisição de meios para reconhecer estilos e obras. Esse fato suscitou questionamentos: Como levar os alunos a perceberem que a apreciação vai muito além do mero reconhecimento? Como favorecer as relações entre as suas próprias vivências e os saberes da História da Arte, sem cair em uma visão reducionista? As reflexões acerca da mediação da arte (Martins, 2001) levaram a docente à busca de metodologias que visassem a experiência estética (Dewey, 1980) e conseqüentemente, a interação dos alunos com conteúdos desconhecidos pela grande maioria, rumo à construção de um saber sensível e significativo (Maffesoli, 1998 e Duarte, 2001). Com base na Fenomenologia, antes de trabalhar com conceitos dos teóricos da História da Arte, realizaram-se experiências de leitura de obra (metodologia de Ott), onde foi valorizada a percepção primeira dos alunos sobre as imagens. O desenvolvimento do trabalho indica que essas teorias do Ensino de Arte se mostraram como possibilidades enriquecedoras para a docência de História da Arte, e merecem investigação aprofundada acerca de suas possibilidades.
“Félix Émile Taunay – cidade e natureza no brasil”: enfrentamentos da pesquisa e metodologia
Authors:   Universidade de São Paulo, Dias Elaine
Published: September 2021

Texto apresentado no II Encontro de História da Arte.
Arte tecnológica: um percurso brasileiro
Authors:   Universidade Federal Fluminense, Gomes Rose Mary Louzada
Published: September 2021

Neste trabalho apresento a trajetória percorrida pela arte durante o século XX, para se chegar à era da arte tecnológica. Nele foi feita uma síntese dos movimentos artísticos dos anos 40, 50 e 60, enfatizando a arte cinética, primórdios da vertente arte/ciência/tecnologia no Brasil. Foi justamente nestes momentos que as artes visuais, tomaram direções radicais, quanto aos suportes, maneira de expressar e de representar os objetos artísticos. Procuro demonstras estas transformações e o processo de hibridizações desse novo fazer artístico que acarretou também, novas posturas dos artistas, como poderá ser observado nas análises das obras dos artistas Abraham Palatnik e Waldemar Cordeiro, pioneiros na arte tecnológica no Brasil. Estes momentos foram de transgressões, rupturas, desconstruções e construções para as artes deste início de milênio. Para alguns artistas, foram momentos de transição instrumental e para outros, de elaboração do novo fazer artístico a partir do computador e da informática dentro do universo artístico.
Cidade, memória e literatura na infância berlinense de Walter Benjamin
Authors:   Universidade de São Paulo, Imanishi Raquel
Published: September 2021

W. Benjamin escreveu a Infância berlinense entre 1932 e 1938. Sobre essa coleção de reminiscências em miniatura diz um dos biógrafos do filósofo não se tratar de um olhar nostálgico para a vida vivida, mas antes da “tentativa de pôr ante os olhos, através da escrita, a constelação alterada de relações políticas, sociais e culturais de toda uma vida”. Apreensão moderna e contraditória de um passado sem volta, o livro talvez possa ser lido como vestígio de uma história de que se tem pouca notícia. Nascido em 1892 em BerlimCharlottemburg, Benjamin não só cresceu numa cidade que se transformava, mas numa nação unificada pelo alto, na qual prosperava uma “vontade de potência” imperialista. É a esse tempo cheio de mudanças e promessas, que termina em 1914, que Benjamin recorre na aurora de uma segunda catástrofe, a qual não sobreviveria. A leitura de um misterioso fragmento desse livro pretende retomar os nexos entre cidade, memória e literatura.
Freud e a história da arte: notas sobre algumas implicações metodológicas do aporte psicanalítico
Authors:   Universidade Federal de São Carlos, Lana Rita de Cássia
Published: September 2021

Por mais interessante que possa parecer a interpretação da arte segundo o método psicanalítico, desde que Freud publicou "A interpretação dos sonhos" (isto é, fornecendo um arsenal de novos conceitos que pudessem lançar alguma luz sobre o significado de imagens e representações subjetivas), para a história da arte o ponto em questão foi bem estabelecido por Gombrich...
Rubens Mano e os fluxos luminosos
Authors:   Universidade Federal do Pará, Maneschy Orlando
Published: September 2021

As relações entre espaço e imagem vêm permeando o trabalho do artista brasileiro Rubens Mano (1960- ) desde suas investigações iniciais acerca do ambiente urbano, ainda na década de 80, quando a fotografia mostrava-se como o único canal de articulação para o artista apresentar suas reflexões sobre tais questões. Sua produção artística se estabelece dentro de um campo no qual questões espaciais e luminosas se instauram para colocar em xeque aquilo que nos é visível. Trabalhando com a transformação do espaço em imagem, Rubens Mano, cuja formação universitária foi na área da arquitetura e urbanismo, articula questões nas quais a luz aparece com elemento de importância fundamental.
Objetividade, estrutura e correspondência entre os campos do conhecimento
Authors:   Universidade de São Paulo, Mari Marcelo
Published: September 2021

Mário Pedrosa fez uso da Gestalt menos para a justificação de uma arte de base geométrica, que ressaltasse efeitos das leis da estrutura da visão, e mais para a compreensão da atividade perceptiva e de sua atividade cognoscente. De fato, a adoção da lei primordial – segundo a qual a percepção funda-se em um todo estruturado que não pode ser inferido de suas partes isoladas, sejam elas somadas ou apenas justapostas – revelava o intuito de Pedrosa em encontrar uma unidade da percepção que sustentasse com plausibilidade o conhecimento a partir das relações intrínsecas dos elementos nela estruturados. Por sua vez, esse conhecimento possuía objetividade devido às leis próprias da atividade perceptiva e partia de um acordo entre sujeito e objeto. Objetividade, estrutura e totalidade – ou percepção sincrética global – constituíam a garantia de consonância entre o conhecimento proporcionado pela arte e aquele resultante do desenvolvimento de outros campos do conhecimento.
La legislación canónica esclavista americana en Lima y México colonial, siglos XVI y XVII
Authors: Gonzales Jauregui Yobani Maikel
Published: September 2021

La Iglesia en la búsqueda de establecer una sociedad esclavista y católica al mismo tiempo, construyó una estructura legal que permitió que a todos los integrantes de la nueva sociedad colonial se les reconociera sus derechos espirituales. De esta forma, el bautismo, matrimonio, extremaunción, etc., eran derechos inalienables a todo ser humano, así fueran esclavizados, reconociéndoles su derecho a la libre elección matrimonial y a la cohabitación. Estableciendo penas pecuniarias y la excomunión para aquellas personas que interfieran en el normal desarrollo de los derechos sacramentales. Toda esta legislación se plasmó en los Concilios Limenses, Concilios Provinciales Mexicanos, Sínodos de Lima, Puerto Rico, Cuba, etc.
O ensino secundário na Capital da província de Minas Gerais (1830-1840)
Authors: Nogueira Vera Lúcia
Published: September 2021

Este artigo analisa os debates e disputas que estiveram na gênese da criação do primeiro colégio público de Ensino Secundário da província de Minas Gerais, denominado “Collegio de Nossa Senhora de Assumpção”. Ancorada nos estudos da Nova História Política e da História da Educação, analisamos jornais da época, relatórios provinciais e a legislação educacional. Evidenciam-se disputas de poderes, especialmente, entre o Poder Civil e Poder Eclesiático, no contexto das estratégias governamentais voltadas à organização e institucionalização do campo educativo provincial decorrentes da emenda constitucional de 1834. A modernização da Província e as demandas profissionais para as novas burocracias imperiais definiriam o teor dos debates orientando as críticas ao distanciamento das práticas e dos conteúdos presentes na formação da mocidade mineira.
El conocimiento especializado de um maestro de primaria cuando enseña la resta
Authors: Alberca Mercedes , Contreras Luis Carlos
Published: September 2021

Esta pesquisa visa compreender o conhecimento especializado que um professor de matemática possui em relação à subtração, em cujo processo de ensino utiliza algoritmos abertos baseados em números (método ABN), utilizando o modelo Mathematics Teacher Specialized Knowledge (MTSK) para sua análise. Para o efeito, foi realizado um estudo de caso de um professor primário do segundo ano de uma Escola Concertada de Huelva. A partir das transcrições das gravações de quatro atividades em que a subtração é trabalhada, bem como de uma posterior entrevista semiestruturada, foram obtidas evidências e indícios que mostram que o professor possui conhecimento especializado em subdomínios de conhecimento de conteúdo e conhecimento didático conteúdo, o que nos permite presumir uma relação entre esse conhecimento e a formação docente no método ABN.
Multiple Sistem Atrophy: Sebuah Laporan Kasus
Authors: Rahmarini Edfina , Hamdan Muhammad , Nugraha Priya , Sugianto Paulus , Haryono Yudha
Published: September 2021

Pendahuluan: Multiple sistem atrophy adalah penyakit degeneratif yang dapat menyebabkan kecacatan bahkan kematian. Sedikit jurnal yang yang membahas tentang diagnosis dan penanganan multiple system atrophy secara menyeluruh. Kasus: Seorang laki-laki berusia 44 tahun datang ke poli saraf dengan keluhan kelemahan pada keempat ekstremitas dengan disertai gejala parkinsonisme yang khas. Pada pemeriksaan neurologis didapatkan gangguan fungsi serebelum. Pada pemeriksaan   MRI kepala dengan kontras didapatkan gambaran khas suatu multipel system atrophy tipe cerebellar. Kesimpulan: Multipel system atrophy adalah kasus degeneratif yang bersifat jarang namun seringkali dapat menyebabkan kematian. Dibutuhkan diagnosis yang cepat dan penanganan yang memadai secara multidisiplin untuk mencegah beratnya gejala multiple system atrophy. Terapi simptomatik dan suportif sangat dibutuhkan untuk meningatkan kualitas hidup pasien.
Hubungan Intensitas Nyeri Kepala, Stres Psikologis, dan Kadar Kortisol Serum pada Penderita Tension Type Headache
Authors: Wisnujono Dion Andriawan , Machfoed Moh. Hasan
Published: September 2021

Pendahuluan: Tension Type Headache (TTH) dapat dipengaruhi banyak faktor, beberapa di antaranya adalah stres dan kadar hormon kortisol. Beberapa penelitian telah menganalisa hubungan nyeri kepala terhadap kortisol,  dan  stres.  Namun, jarang ada penelitian yang menghubungkan ketiganya. Tujuan: Membuktikan adanya hubungan antara intensitas nyeri kepala, stres psikologis dan kadar kortisol serum pada penderita TTH. Metode: Jenis penelitian adalah analitik observasional dengan rancangan cross sectional dengan uji korelasi. Hasil: Pada penelitian ini didapatkan 42 subyek penelitian. Dari pengolahan   data, didapatkan p= 0,594. Yang berarti tidak ada korelasi signifikan antara intensitas nyeri kepala dengan stres psikologis. Sementara itu, pada intentistas nyeri kepala dengan kadar kortisol didapatkan korelasi signifikan dengan p=  0,04. Pada   stres dan kadar kortisol tidak ditemukan korelasi signifikan dengan p= 0,154. Kesimpulan: Ada hubungan yang signifikan antara intensitas nyeri kepala dengan kadar kortisol serum. Sebaliknya, pada intensitas nyeri kepala dengan stres psikologis  dan stres psikologis dengan kadar kortisol serum, tidak memiliki hubungan yang signifikan.
Korelasi Usia dan Jenis Kelamin dengan Angka Kejadian Meningioma
Authors: Damayanti Arlia Ayu , Kalanjati Viskasari Pintoko , Wahyuhadi Joni
Published: September 2021

Pendahuluan: Meningioma merupakan tumor otak primer yang berasal dari jaringan arakhnoid. Angka kejadian meningioma di Indonesia menunjukkan peningkatan dari tahun ke tahun. Selain mutasi gen  supresor tumor, meningioma  dapat dipengaruhi oleh faktor eksternal diantaranya usia dan jenis kelamin. Tujuan: Mengetahui hubungan antara usia    dan jenis kelamin dengan angka kejadian meningioma pada pasien di RSUD Dr. Soetomo, Surabaya, Indonesia tahun 2018 berdasarkan derajat keganasannya. Metode: Penelitian ini merupakan studi observasional analitik cross-sectional retrospektif dari data sekunder lembar hasil pemeriksaan patologi anatomi pasien yang dirawat inap melalui SMF. Ilmu Bedah Saraf,  RSUD Dr. Soetomo tahun 2018; data yang tidak lengkap akan dieksklusi. Analisis data dilakukan menggunakan uji  Chi  squre (SPSS 25) dengan tingkat signifikansi p <0,05. Hasil: Didapatkan 45 pasien meningioma yang sesuai dengan kriteria inklusi, dengan mayoritas perempuan (71%) pada kelompok usia 45 – 49 tahun (22,2%), WHO grade I (82%) dengan tipe histopatologi transisional (49%). Terdapat hubungan yang signifikan antara angka kejadian meningioma dengan kelompok   usia tertentu (r = 0,718, p  =  0,025), dan  dengan jenis kelamin (r = 0,441, p = 0,002). Rasio perempuan dibanding laki- laki sebesar 1:2,36. Kesimpulan: Usia dan jenis kelamin berkorelasi erat dengan angka kejadianmeningioma.
Identification and Distribution of Soil Transmitted Helminths around The Shed and Grazing Fields of Madura Cattle in Sub-District of Geger, Bangkalan Regency
Authors: Mahartina Dewi , Mulyati Sri , Soeharsono Soeharsono , Hambal Muhammad
Published: September 2021

This research aims to determine the percentage and kind of Soil Transmitted Helminths contamination in around the shed and grazing field soil of Madura cattle in Sub-District of Geger, Bangkalan District. The research was conducted on July until September 2018. The method of this research used a non-experimental method and through an observation study. The sample of this study is 100 samples of around the shed and grazing field soil, then examined in the laboratory of Helminthology, Division of Parasitology, Faculty of Veterinary Medicine, Universitas Airlangga used Modifed Sucrose 58%. Based on the kind of contamination, the highest contamination was Toxocara sp. (45.9%). Followed by Strongyloides sp. (41.4%), Trichuris sp. (9.5%) and Ancylostoma sp. (3.2%). Based on location, the percentage of grazing fields was higher (70%) than around the shed (50%). The result of statistical analysis using Chi- Square test showed significant differences in the percentage between around the shed and grazing field soil (p<0.05).
The Potency of Anting Anting (Acalypha indica L.) Leaf Extract as An Acaricide on Boophilus microplus in Larvae and Adult Stages In Vitro
Authors: Nurdiana Fitri , Sugiharuti Rahmi , Lukiswanto Bambang Sektiari
Published: September 2021

The purpose of this study was to determine the potency of anting-anting leaf extract (Acalypha indica L.) as an acaricide against larval and adult Boophilus microplus in vitro by observing the mortality rate of B. microplus. The present study design was a completely randomized design. This study used five treatments, including: Tween 80 1% and aquadest (K-), Neguvon (K+), anting-anting leaf extract with a concentration of 3.125% (P1), 6.25% (P2), and 12.5% (P3 ). Each treatment used 5 repetitions and each repetition used 6 B. microplus larval stages and 5 B. microplus adults. Observations were made for 5 hours for the larval stage of B. microplus and 24 hours for the adult stage of B. microplus. Boophilus microplus is declared dead if there is no movement at all when touched with a needle. The data obtained were analyzed using factorial ANOVA and continued with Duncan's multiple distance test. The results showed that the 12.5% anting anting leaf extract treatment showed no significant difference with the treatment using Neguvon. (p>0.05) in larval stage B. microplus, but in adult B. microplus showed a significant difference with Neguvon (p<0.05). The results of the statistical test can be concluded that the extract of anting-anting leaf (A. indica L.) has the potential as an acaricide of B. microplus larval stage in vitro. The higher the concentration of anting anting leaf extract, the higher the acaricide activity.
Prevalence and Scabies Severity Rate on a Goat at Mempawah Hilir, Mempawah District West Kalimantan Province
Authors: Hidayah Arum Maula , Tyasningsih Wiwiek , Soeharsono Soeharsono , Wulansari Retno
Published: September 2021

This research aims to determine the prevalence and severity rate of scabies on goats in Sub-District of Mempawah Hilir, Mempawah, West Kalimantan. The goat livestock used were not determined by age, sex, and breed. The number of goats researched was 100 goats. Scabies prevalence measurement was to divide the number of scabies goats by total goats, then multiplied by 100% and measurement of the severity rate of scabies goats with scoring with grades 1-3 (low), 4-6 (moderate), and 7-9 (heavy). The results obtained scabies prevalence rate of 38% with 38 positive samples from a population of 100 goats and the percentage of severity was 42%, moderate 24%, and 34% severe. This is due to weather factors in the area and the type of cage as well as inadequate maintenance management, thus making many cases of scabies attack goats.
Osmanlı Devleti’nde Afet Yönetimine Bir Örnek: 1889 ve 1890 Malatya Yangınları
Authors: SATILMIŞ Selahattin
Published: September 2021

Malatya kenti, 19. yüzyılın son çeyreğinde birçok felaket yaşadı. 3 Mart 1893 depreminde çok büyük tahribat ve can kaybı yaşayan Malatya, aynı yıl kolera salgını nedeniyle yüzlerce nüfusunu kaybetti. Bu afetlerin birkaç yıl öncesinde ise iki büyük yangın felaketine maruz kalarak, büyük miktarda maddi ve manevi zarara uğradı. İlk yangın 1889 yılı sonlarında çıktı ve Malatya Çarşısı’nı küle çevirdi. Aynı çarşı, daha üzerinden bir yıl geçmeden ikinci ve daha büyük bir yangın felaketi yaşadı. Yangınlarda çarşıdaki dükkânların yanı sıra diğer bazı binalar da büyük zarar gördü. Deprem sonrasında olduğu gibi yangınlar sonrasında da afetzedelerin yaraları sarılmaya çalışıldı. Bu hususta hem Malatya livası (sancağı) ve buranın bağlı olduğu Ma‘mûretü’l-‘Azîz vilâyetinin yöneticileri hem de başkent İstanbul’dan devleti yöneten Osmanlı hükümetinin temsilcilerinin gayretleri ile yangınzedelerin yaraları sarılmaya çalışıldı. Maddi yardımlar yapıldığı gibi Malatya halkına bazı kolaylıklar da sağlandı. Bu çalışmada, bahsi geçen yangınların çarşı ve etrafında yol açtığı zararlar, afetler sonrası yaşananlar, afetzedelerin yaralarının sarılması amacıyla yapılan çalışmalar ve alınan tedbirler arşiv belgeleri ve dönemin gazeteleri ışığında ele alınarak, o dönemde Malatya halkının ve bölge idarecilerinin çektiği maddi ve manevi sıkıntılara yer verildi.
CmPMRl and CmPMrs Were Responsible for Resistance to Powdery Mildew Caused by Podosphaera Xanthii Race 1 in Melon
Authors: Cui Haonan , Fan Chao , Ding Zhuo , Wang Xuezheng , Tang Lili , Bi Yingdong , Luan Feishi , Gao Peng
Published: September 2021

Cucumis melo L. is an economically important crop, the production of which is threatened by the prevalence of melon powdery mildew (PM) infections. We herein utilized the MR-1 (P1; resistant to PM) and M4-7 (P2; susceptible to PM) accessions to assess the heritability of PM (race 1) resistance in these melon plants. PM resistance in MR-1 leaves was linked to a dominant gene (CmPMRl), whereas stem resistance was under the control of a recessive gene (CmPMrs), with the dominant gene having an epistatic effect on the recessive gene. The CmPMRl gene was mapped to a 50 Kb interval on chromosome 12, while CmPMrs was mapped to an 89 Kb interval on chromosome 10. The CmPMRl candidate gene MELO3C002441 and the CmPMrs candidate gene MELO3C012438 were identified through sequence alignment, functional annotation, and expression pattern analyses of all genes within these respective intervals. MELO3C002441 and MELO3C012438 were both localized to the cellular membrane and were contained conserved NPR gene-like and MLO domains, respectively, which were linked to PM resistance. In summary, we identified patterns of PM resistance in the disease-resistant MR-1 melon cultivar, and conducted finally-mapping to identify two putative genes linked to resistance. Our results offer new genetic resources and markers guide the future molecular marker-assisted breeding of PM-resistant melon.
Elevated Serum Levels of Herpes Virus Entry Mediator and IL-5 in Cough Variant Asthma Versus Classic Asthma Patients
Authors: Yao Can , Yang Zhong , Chen Dandan , Fang Wei , Zhang Yu , Li Binbin , Li Sinian , Chen Rongchang , Shi Fei
Published: September 2021

Background

Cough variant asthma (CVA) is a special phenotype of asthma. We aimed to elucidate the differential inflammatory features in patients with CVA in contrast to patients with classic asthma (CA).
Methods

A total of 68 patients with persistent uncontrolled asthma (34 with CVA, 34 with CA) were enrolled. We collected the demographic data, pulmonary function test (PFT) parameters, hematological variables, and several serum biomarkers. The independent-samples t test was used for analyzing measurement data, and Chi-square test was for count data. Multivariate logistic regression analysis was used to determine the possibility of different phenotypes. Receiver operating characteristic (ROC) curves were generated to evaluate the values of biomarkers for distinguishing between CVA and CA. Linear correlation analysis was performed to assess the linear relationship between two variables.
Results

Compared with CA group, CVA group had a higher percentage of females, lower proportion of asthma family history, shorter disease course, and better pulmonary function (P all < 0.05). Increased levels of blood eosinophil count (P = 0.045), eosinophil percentage (P = 0.046), serum IL-5 (P = 0.011), and serum herpesvirus entry mediator (HVEM) (P = 0.002) were also found in CVA patients compared to those in CA patients compared to those in CA patients. The logistic analysis revealed that serum HVEM had a strong predictive power for CVA group (OR = 1.105, P = 0.015). The sensitivities and specificity of serum HVEM and IL-5 to distinguish between CVA and CA at optimal cut-offs were 85.0% and 61.1%; 85.0% and 61.1%, respectively. Area under the curves (AUCs) of serum HVEM and IL-5 were 0.789 and 0.739, respectively. Furthermore, serum HVEM and IL-5 had no correlation with PFT parameters in CVA group (P all > 0.05).
Conclusions

Elevated serum levels of HVEM and IL-5 are exhibited in CVA patients, which may indicate their important roles in the pathogenesis and progression of CVA.
Combination of Shengji ointment and bromelain in the treatment of exposed tendons in diabetic foot ulcers: Study protocol for a non-blind, randomized, positive control clinical trial
Authors: zhao yang , gao rui , Dai Xinyue , Sun Xu , Zhang Zhaohui , Gao Hongyang
Published: September 2021

Background : Diabetic foot ulcers often affect tendon tissue. Consequently, the infection may spread proximally along the tendon, leading to amputation or even the death of patients. Exposed, degenerated, and necrotic tendons are key factors affecting the healing of diabetic foot ulcers. The effective treatment of the tendon involvement may positively affect the prognosis. In clinical practice, treatment with Shengji ointment and bromelain induces islands of granulation tissue on the denatured tendon surface, which gradually grows and merges. Ideally, the exposed tendon is covered entirely by granulation tissue. This trial aims to assess the effect of a combined treatment regime of Shengji ointment, which has been shown to regenerate muscle tissue and pineapple protease in preventing the loss of function and amputation caused by tendon necrosis. This trial will provide high-quality evidence for the effectiveness of this combination in healing diabetic ulcers with tendon necrosis. Methods: The sample size will be 180 patients who will be randomly assigned 1:1 to a treatment group (90 patients) using Shengji ointment combined with bromelain and a control group (90 patients) using hydrocolloid dressing. Both groups will continue their conventional treatments, such as blood glucose and blood pressure medication, lipid regulation, antiplatelets, and others. The primary outcome will be the wound coverage with granulation tissue. Secondary outcomes will be the wound healing rate, amputation extent (where needed), time to granulation, and the Maryland Foot Score. Other efficacy outcomes will be the time to debridement of necrotic tendon tissue and granulation tissue score. Discussion: This study will treat patients with diabetic foot ulcers with exposed, degenerated, and necrotic tendons with Shengji ointment and bromelain. The trial aims to promote regeneration and healing, to preserve the limb and its function, and to develop a comprehensive and effective protocol that can be applied to promote the healing of exposed tendons in diabetic foot wounds. Trial registration: ChiCTR2000039327; date of registration: 2020-10-23. http://www.chictr.org.cn/com/25/showproj.aspx?proj=62692
Analog/RF Performance of Triple Material Gate Stack-Graded Channel Double Gate-Junctionless Strained-Silicon MOSFET with Fixed Charges
Authors: Suddapalli Subba Rao , Joseph Rani Deepika Balavendran , Chintala Vijaya Durga , Saramekala Gopi Krishna , D Srikar , Nistala Bheema Rao
Published: September 2021

In this paper, analog/radio frequency (RF) electrical characteristics of triple material gate stackgraded channel double gate-Junctionless (TMGS-GCDGJL) strained-Si (s-Si) MOSFET with fixed charge density is analyzed with the help of Sentaurus TCAD. By varying the various device parameters, the analog/RF performance of the proposed TMGS-GCDG-JL s-Si MOSFET is evaluated in terms of transconductance-generationfactor (TGF), early voltage, voltage gain, unity-powergain frequency ( f max ), unity-current-gain frequency ( f t ), and gain-transconductance frequency product (GTFP). The results confirm that the proposed TMGS-GCDGJL s-Si MOSFET has superior analog/RF performance compared to gate stack-graded channel double gatejunctionless (GS-GCDG-JL) s-Si device. However, the proposed MOSFET has less transconductance and less output conductance when compared with the GS-GCDGJL s-Si device in above threshold region, and reverse trend follows in sub-threshold region.
The Clinical and Genetic Characteristics of Chinese Male Pediatric Patients with Congenital Hypogonadotropic Hypogonadism
Authors: Wang Yi , Qin Miao , Fan Lijun , Zhang Beibei , Gong Chunxiu
Published: September 2021

Purpose：Congenital hypogonadotropic hypogonadism (CHH) are invided into Kallmann Syndrome (KS) and normosmic HH(nHH). The clinical and genetic characteristics of CHH are more studied in adults, but less in pre-adults. Methods: Medical records of 126 patients with CHH at our hospital during 2008−2020 were evaluated. Results: Totally, seven patients (5.6%) had hypospadias. Among 49 patients with positive family history, delayed puberty, KS/nHH and olfactory abnormalities accounted for 44.9%, 16.3%, and 12.2%, respectively. Sixty-five patients completed the hCG prolongation test, and T levels of 24 patients were lower than 100 ng/dl. 25 CHH-related genes were found in 78 patients, digenic mutations in 23 patients, and trigenic mutations in 3 patients. The most common pathogenic genes were FGFR1 (21.1%), PROKR2 (17.9%), ANOS1 (12.6%) and CHD7 (12.6%). The oligogenicity rate of common autosomal dominant heredity genes accounted for 50.0% (FGFR1, 10/20) and 33.3% (CHD7, 4/12), of autosomal recessive heredity gene PROKR2 accounted for 47.1% (8/17). And W178S accounted for 58.8% of all mutations in PROKRR2.Conclusion: Micropenis and cryptorchidism are important cues for CHH in pre-adulthood; hypospadias is a rare phenotype of CHH. At least 22.9% of patients tested had testicular Leydig cell dysfunction (dual CHH). Oligogenic mutations were found in 27.4% of all patients with CHH. W178S in PROKRR2 maybe a founder mutation in Chinese CHH crowds.
Role of Purged Air On Synthesis of Mesoporous NiO/C Composite And Its Application On Waste Water Treatment
Authors: Ramalingam Saravanakumar , Karpagasundaram Muthukumaran , Chandrasekaran Sivasankari , Narayanan Sathiyapriya , Sakthipandi Kathiresan
Published: September 2021

Two different methods were employed to synthesis NiO/C composite from agricultural waste. The mesoporous composite was successfully synthesized via a novel precipitation method in the presence of dissolved gases. The morphology of the composites were differentiated by characterisation techniques such asx-ray Diffraction (XRD), the point of zero charge (pHpzc), field emission scanning electron microscope (FESEM), Fourier transform infrared spectroscopy (FTIR), energy dispersive x-ray analysis (EDAX) and vibrating sample magnetometer (VSM). Then, the mechanism of synthesis was elucidated using the above experimental characterisation data. FESEM and EDAX report of Ni(OH)2-carbon composite clearly showed the role of dissolved gases on synthesis. Both the composites were subjected as the adsorbent to eliminate/remove the toxic Pb(II) ions from the wastewater. Batch adsorption experiments were carried out to compare the Pb(II) ions removal capability of both the composite materials. The parameters such as the effect of pH, the dosage of the adsorbents and initial concentration were studied. At the optimized conditions, isotherm studies for each of the adsorbents were also carried out. The isotherm results revealed that the maximum removal capacity qe (mg/g) was 30.78 for PJNC and 43.48 for PJGNC. The VSM analysis confirmed that both the adsorbents were soft magnetic materials. Hence, they could be competently separated from salted/treated water using the magnetic field.
Multi-omics Analysis of the Symbiotic Green Algae, Chlorella Variabilis, Revealing the Genetic Basis of the Obligate Endosymbiotic Lifestyle
Authors: Minei Ryuhei , Hoshina Ryo , Higuchi Rina , Chen Lin , Akizuki Yuki , Terabayashi Yasunobu , Kira Satoshi , Kitagawa Masanari , Suzaki Toshinobu , Ogura Atsushi
Published: September 2021

Background: Photosynthetic eukaryotes have evolved through the acquisition of plastids by secondary endosymbiosis, a process that requires several steps. Immediately before plastid acquisition, the genome of the symbiont is known to be dramatically reduced, but few studies have focused on the genomic changes in the symbiont at the early stages of secondary endosymbiosis. Methods: To investigate the genetic basis of the transition from facultative to obligate endosymbiosis, we compared the genomes of Chlorella variabilis, a representative symbiotic alga, with that of Paramecium bursaria, to compare closely related free-living species and transcriptomes between organisms in symbiotic and non-symbiotic conditions. Results: We found that the non-reduced genome of C. variabilis and its genes play a crucial role in endosymbiosis, being involved in cell wall biogenesis and degradation, and metabolic exchanges with the host. Our results suggest that the genetic mechanism underlying the enhancement of photosynthesis under symbiosis is the increasing light absorption efficiency and carbon fixation capacity of the endosymbiont, resulting in an increase in the supply of maltose to P. bursaria.
The Oncogenic Role of AXIN1 In Human Tumors: A Pan-Cancer Analysis of AXIN1.
Authors: Wang Jinzhou , Shi Xiangjun , Yao Xingchen , Xu Ziyu , Du Xinru
Published: September 2021

Background: Although emerging cell- or animal-based evidence supports the correlation between AXIN1(Axis inhibition protein 1) and cancers，no pan-cancer analysis is accessible. Method: We thus investigate the possible oncogenic characters of AXIN1 by 33 tumor types based on the datasets of TCGA (The cancer genome atlas) and GEO (Gene expression omnibus). Result: AXIN1 has a high expression in lots of tumors, and obvious relevance between AXIN1 expression and prognosis of cancer patients, such as LICH (Liver hepatocellular carcinoma) and breast cancer. We observed an increase phosphorylation level of S486/S493 in breast cancer and UCEC (Uterine Corpus Endometrial Carcinoma). AXIN1 expression shows a correlation with T cell regulatory in several cancers such as LIHC and LUAD (Lung adenocarcinoma). Furthermore, enrichment exist between Wnt signaling pathway, Hippo signaling pathway and pathways in cancer and the functional mechanisms of AXIN1.Conclusions: Our first pan-cancer study provides a relatively complete interpretation of oncogenic characters of AXIN1 though different tumors.
Hidden Markov Trust for Attenuation of Selfish and Malicious Nodes in the IoT Network
Authors: Joshi Gamini , Sharma Vidushi
Published: September 2021

The exposure of IoT nodes to the internet makes them vulnerable to malicious attacks and failures. These failures affect the survivability, integrity, and connectivity of the network. Thus the detection and elimination of attacks in a timely manner become an important factor to maintain the network connectivity. Trust-based techniques are used in understanding the behavior of nodes in the network. Several researchers have proposed conventional trust models that are power-hungry and demand large storage space. Succeeding this Hidden Markov Models have also been developed to calculate trust but the survivability of network achieved from them is low. To improve the survivability selfish and malicious nodes present in the network are required to be treated separately. Hence, an improved Hidden Markov Trust (HMT) Model is developed in this paper which accurately detects the selfish and malicious nodes that illegally intercept the network. An algorithm is generalized for learning the behavior of nodes using the HMT model with the expected output. The evaluated node’s likelihood functions differentiate the selfish node from the malicious node and provide independent timely treatment to both types of nodes. Further, comparative analysis for attacks such as black-hole, grey-hole, and sink-hole has been done and performance parameters have been extended to survivability-rate, power-consumption, delay, and false-alarm-rate, for different networks sizes and vulnerability. Simulation result provides a 10% higher PDR, 29% lower overhead, and 15% higher detection rate when compared to FUCEM, FTCSPM, and OADM trust models presented in the literature.
Performance Analysis of Linear Precoding in Downlink Based on Polynomial Expansion on massive MIMO systems
Authors: THURPATI SAMMAIAH , Muthuchidambaranathan P
Published: September 2021

The performance of linear precoding schemes in downlink Massive MIMO systems is dealt with in this paper. Linear precoding schemes are incorporated with zero forcing (ZF) and maximum ratio transmission (MRT), truncated polynomial expansion (TPE), regularized zero force (RZF) in Downlink massive MIMO systems. Massive MIMO downlink output is evaluated with linear precoding included. This paper expresses the performance of achievable sum rate linear precoding with variable signal-to-noise (SNR) ratio and achievable sum rate and several transmitter-receiver antennas, such as imperfect CSI, less complex processing and inter-user interference. The transmitter has complete state information on the channel. The information narrate how a signal propagates to the receiver from the transmitter and reflects, for example, the cumulative effect of distance scattering, fading, and power decay. They show that the performance analysis of two linear precoding techniques,i.e.Maximum Ratio Transmission (MRT) and Zero Forcing (ZF) for downlink mMIMO output network over a perfect chain. The results show the improved ZF precoding achievable sum rate compared to the MRT precoding schemes and also compared the average achievable rate RZF and TPE.
Hybrid TDR-MI Based Wireless Sensor Network for Underground Water Pipeline Leakage Detection and Localization Using Pressure Residuals and Classifiers.
Authors: Vankdothu Ramdas , Bhukya Hanumanthu , Bhukya Raghu Ram
Published: September 2021

The pipeline leakage detection and leak localization trouble is a highly demanding and dangerous issue. Underground pipelines are a critical mode of transporting enormous fluid volumes (e.g., water) across extended distances. Solving this problem will save the country much money and resources, but it will also protect the environment. On the other hand, present leak detection technologies are insufficient for monitoring underground pipelines due to the extreme subterranean environmental conditions. This study proposes a hybrid wireless sensor network based on TDR (time domain reflectometry) and magnetic induction for monitoring underground pipelines to solve these problems. In this scenario, TDR is deployed beneath an MI-based wireless sensor network. TDR precisely locates the leak and dramatically decreases the amount of time required for inspection. We offer a wireless sensor network based on MI technology for low-cost, real-time leak detection in subsurface pipes. MISE-PIPE identifies leaks by integrating data from a range of different types of sensors installed within and around underground pipelines. Ad-hoc WSNs are used to measure pressure. (WDNs) is a hot topic that has piqued researchers' interest in recent years. Time and accuracy are critical components of leak localization, as they substantially impact the human population and economy. Statistical classifiers acting in the residual space are offered as a general method for leak localization. Classifiers are trained on leak data from all network nodes, taking demand uncertainty, sensor preservative noise, and leak magnitude on the account. Following leak identification and localization, all monitoring data is forwarded to the CH using the K-means clustering method, which serves two critical functions: optimal clustering and prolonging the Network Lifetime (NL) and preserving the QoS. The clustering method is optimized using the K-Means approach .
Fingerprint Presentation Attack Detection using Referential Quality Metrics and Minutiae Count
Authors: Verma Akhilesh , Gupta Anshadha , Akbar Mohammad , Yadav Arun Kumar , Yadav Divakar
Published: September 2021

The fingerprint presentation attack is still a major challenge in biometric systems due to its increased applications worldwide. In the past, researchers used Fingerprint Presentation Attack Detection (FPAD) for user authentication, but it suffers from reliable authentication due to less focus on reducing the ‘error rate’. In this paper, we proposed an algorithm, based on referential image quality (RIQ)-metrics and minutiae count using neural network, k-NN and SVM for FPAD. We evaluate and validate the error rate reduction with different machine learning models on the public domain, such as LivDet crossmatch dataset2015 and achieved an accuracy of 88% with a neural network, 88.6% with k-NN and 88.8% using SVM. In addition, the average classification error (ACE) score is 0.1197 for ANN, 0.1138 for k-NN and 0.1117 for SVM. Thus, the results obtained show that it was achieved a reasonable accuracy with a low ACE score with respect to other state-of-the-art methods.
Rank Change and Growth Within Social Hierarchies of the Orange Clownfish, Amphiprion Percula
Authors: Fitzgerald Lucy M , Harrison Hugo B , Coker Darren J. , Saenz-Agudelo Pablo , Sriniva Maya , Majoris John E. , Einarsson Lisa Boström , Pujol Benoit , Bennett-Smith Morgan , Thorrold Simon R. , Planes Serge , Jones Geoffrey P. , Berumen Michael L.
Published: September 2021

Social hierarchies within groups define the distribution of resources and provide benefits that support the collective group or favor dominant members. The progression of individuals through social hierarchies is a valuable characteristic for quantifying population dynamics. On coral reefs, a number of small site-attached fish maintain size-based hierarchical communities where individuals queue through social ranks. The cost of waiting in a lower-ranked position is outweighed by the reduced risk of eviction and mortality. Clownfish exist in stable social groups with subordinate individuals queuing to be part of the dominant breeding pair. Site attachment to their host anemone, complex social interactions, and relatively low predation rates make them ideal model organisms to assess changes in group dynamics through time in their natural environment. Here, we investigate the rank changes, and isometric growth rates of individual orange clownfish, Amphiprion percula, from 247 naturally occurring social groups in Kimbe Island, Papua New Guinea (5°12’13.54” S, 150°22’32.69” E). We use DNA profiling to assign and track individuals over an eight-year time period in 2011 and 2019. Over half of the individuals survived alongside two or three members of their original social group, with twelve breeding pairs persisting over the study period. Half of the surviving individuals increased in rank and experienced double the growth rate of those that maintained their rank. Examining rank change over a long-term period in a wild fish population gives new insights and highlights the complexity and importance of rank and social hierarchy in communal site-attached reef fish.Subject Area: behavior, ecology, evolution
Risk Models Based On Populations In High-Risk Areas of Oesophageal Cancer In China For Improving The Oesophageal Cancer Diagnosis Rate
Authors: Yang Guodong , Yu Xiaogang , Long Xiaoqi , Zhang Xiaoming , Du Weiwei , Wang Yingbang , Wu Linyi , Mu Zhao , Chen Yuling , Li Zhen , Zhang Xiaoying , Pu Ke
Published: September 2021

Background: To improve the diagnostic efficiency of early oesophageal cancer, it is of great significance to develop an effective risk prediction model. This study aimed to identify a high-risk population with oesophageal squamous cell carcinoma (ESCC) based on a population screening model.Methods: From 120 target townships randomly selected from 150 villages selected in Nanchong City, Sichuan Province, China, from Jan 2016 to Sep 2019, a total of 6409 subjects were screened. Each patient underwent standard endoscopy and narrow band imaging (NBI) and iodine staining indicator biopsies to evaluate oesophageal cancer and precancerous lesions. Before endoscopy, the subjects completed a questionnaire about ESCC risk factors. Variables were evaluated by univariate analysis, and variables significantly related to ESCC were extracted by using a logistic regression model. We used the Akaike information criterion to develop the final model structure and the coding form of variables with multiple metrics. We developed two sets of models to define severe dysplasia and above (SDA) and moderate dysplasia and above (MDA) as prognostic events, respectively. Results: The areas under the receiver operating characteristic curve (AUROC) were0.896 (95%CI, 0.888-0.903) and 0.825 (95% CI, 0.816-0.835) for our SDA and MDA models, respectively. MDA-related and SDA-related factors included age, sex, cigarette smoking, alcohol drinking, pharyngeal foreign body sensation, swallowing obstruction, pain behind the sternum, and discomfort behind the breastbone.Conclusions: we developed an easy-to-use model to identify individuals with high risk of dysplasia or oesophageal cancer in high-risk areas of oesophageal cancer in China.
Effectiveness and safety of regdanvimab in patients with mild-to-moderate COVID-19: A retrospective cohort study
Authors: Heo Jeonghun , Park Susin , Je Nam Kyung , Kim Dong Wan , Park Miran
Published: September 2021

Regdanvimab has decreased the time to clinical recovery from coronavirus disease 2019 (COVID-19) and lowered the rate of oxygen therapy according to the results from Phase 2 randomized controlled trial. More information is needed about the effects and safety of regdanvimab. We analyzed the medical records of patients with high-risk mild or moderate COVID-19 being admitted to Busan Medical Center between December 1, 2020, and April 16, 2021. A propensity score (PS) matched analysis was conducted to compare patients with and without regdanvimab. The primary outcome was in-hospital death or disease aggravation. Among 1,617 selected patients, 970 (60.0%) were indicated for regdanvimab. Among a 1:1 PS-matched cohort of 377 patients each treated with and without regdanvimab, regdanvimab significantly reduced the primary endpoint (odds ratio [OR], 0.194; 95% confidence interval [CI], 0.112–0.320; p < 0.001). Regdanvimab was associated with a significantly lower risk of disease aggravation without increasing adverse reactions.
An Analysis of The Application of “WeChat + Micro-Courses” In Different Majors of Medical University Students
Authors: Liu Lu , Yu Qiurun , Tang Qiuqin , Wu Wei
Published: September 2021

Background: WeChat and micro-courses have become important tools for improving medical education. However, most research just focused on one of them, and investigations about “WeChat + micro-courses” teaching mode were still lacking. Purpose: The aim of this study was to investigate medical students’ use of WeChat and micro-courses and to analyze the possibility of “WeChat + micro-courses” teaching mode.Methods: This investigation was conducted among 534 full-time undergraduates in Nanjing Medical University. A self-reported questionnaire was adopted to collect data. Data were entered and checked with EpiData 3.0 and were analyzed with STATA 13.Results: 534 participants successfully completed the questionnaires. Most students in all specialties used WeChat. More students in preventive medicine subscribed to OAs related to other majors (χ2 = 28.49, P < 0.01). In three majors, almost 80% of students spent less than 10 minutes or 10-30 minutes browsing OA articles every day. As for micro-courses, using frequency in biostatistics was significantly higher than that in preventive medicine and hygienic analysis and detection (χ2 = 16.68, P < 0.01). Plenty of students complained about the lack of interactions while learning with micro-courses.Conclusions: It was promising to apply “WeChat + micro-courses” mode in medical education.
The Value of Dual-Energy CT Imaging In The Clinical Diagnosis of Gout
Authors: GAO Xiulin GAO , GAO Huanling , ZHANG Liyun , ZHANG Liqing
Published: September 2021

Objective To explore the clinical diagnostic value of dual-energy CT imaging technology in patients with gout.Methods A total of 83 suspected gout patients admitted from June 2019 to December 2020 were selected as research subjects. Dual-energy CT and gold standard examination were performed on all patients. The detection rates of urate crystals were compared between the two methods. Clinicians performed physical examinations on patients with confirmed gout, and the examination results were compared with the results of urate crystals found by dual-energy CT.Results The sensitivity, specificity, negative predictive value, and positive predictive value of dual-energy CT imaging in diagnosing gout were 92.31%, 83.33%, 75%, and 95.24%, respectively. The kappa value was 0.73, and the area under the ROC curve was 0.88 (95% confidence interval, 0.77～0.99, P < 0.01). Compared with clinical physical examinations, the number of urate crystal deposits detected by dual-energy CT imaging was 4.40 times that of the former. The detection rate of urate crystals and bone destruction in patients with chronic intermittent gout by dual-energy CT examination was higher than that in the acute phase. (The χ2 values ​​were 4.912 and 8.018, and the P values were 0.027 and 0.005, respectively.)Conclusion Dual-energy CT imaging technology can clearly and accurately display urate deposition in patients with gout. It demonstrates good reliability and a high clinical application value.