bluuebunny/crossref_metadata_2025 huggingface dataset:
Public employee’ job satisfaction, life satisfaction and burnout levels’ assessment by some socia-demographic factors
Kamu çalışanlarının iş doyumu, yaşam doyumu ve tükenmişlik düzeylerinin bazı sosyo-demografik unsurlara göre değerlendirilmesi
Authors: Ural Uslan Yurdanur
Published: August 2016

This research aims to assess whether the public employees' job satisfaction, life satisfaction and level of burnout differentiate by some demographic variables. Besides, the research addresses the correlations among the job satisfaction, life satisfaction and level of burnout of the public employees. The research's units of analysis are the 436 public staff that perform their duties in Kilis province center and the connected towns. Minnesota Job Satisfaction Index, Life Satisfaction Index, Maslach Burnout Index and Personal Information Form are used as the data collection tools. Explanatory factor analysis and cronbach's alpha analysis are utilized to identify validity and reliability of the sub-dimensions of the burnout and job satisfaction. Mann-Whitney U test and Kruskal Wallis test are conducted in the data analysis. In addition, the significance test among the variables are analyzed by the Spearman Rank Correlation technic. The research findings are; a positive correlation between job satisfaction and life satisfaction and a negative correlation between burnout variable with both job satisfaction and life satisfaction. A significant differentiation is also observed in the public employees' job satisfaction, life satisfaction and burnout levels in accordance with their changing demographic variables. ÖzetBu araştırma kamu çalışanlarının iş doyumları, yaşam doyumları ve tükenmişlik düzeylerinin bazı demografik değişkenlere göre faklılaşıp farklılaşmadığını incelemek amacıyla yapılmıştır. Ayrıca araştırma kamu çalışanlarının iş doyumları, yaşam doyumları ve tükenmişlikleri arasındaki ilişkiyi ele almaktadır. Araştırma Kilis ili merkezinde ve ilçelerinde görev yapan 436 kamu çalışanından oluşmaktadır. Veri toplama aracı olarak, Minnesota İş Doyumu Ölçeği, Yaşam Doyumu Ölçeği, Maslach Tükenmişlik Ölçeği ve Kişisel Bilgi Formu Kullanılmıştır. Tükenmişlik ve iş doyumu ile ilgili alt boyutların geçerlilik ve güvenirliğini belirlemek için açıklayıcı faktör analizi ve cronbach’salpha analizi yapılmıştır. Elde edilen verilerin analizinde  Mann-Whitney U testi, Kruskal Wallis testi kullanılmıştır. Ayrıca değişkenler arasında anlamlı bir ilişkinin olup olmadığı Spearman Sıra Korelasyonu tekniği ile analiz edilmiştir. Araştırma sonunda, iş doyumu ve yaşam doyumu arasında pozitif yönlü, tükenmişlik ile iş doyumu ve yaşam doyumu arasında negatif yönlü bir ilişki olduğu saptanmıştır. Kamu çalışanlarının iş doyumları, yaşam doyumları ve tükenmişliklerinde demografik değişkenlere göre anlamlı düzeyde farklılaşma görülmüştür.
Exploitation and Exploration in International Joint Ventures: Moderating Effects of Partner Control Imbalance and Product Similarity
Authors: Lu Jin Jason , Zhou Kevin Zheng , Wang Yonggui
Published: August 2016

International joint ventures (IJVs) need to exploit their existing resources as well as explore new capabilities to capture the potential in emerging markets. This study develops a contingent view, arguing that the efficacy of exploitation and exploration depends on the levels of control imbalance and product similarity between an IJV's foreign and local partners. A sample of 198 IJVs in China reveals that partner control imbalance has a U-shaped moderating effect on the relationship between exploitation and IJV new product performance but has an inverted U-shaped moderating effect on the effectiveness of exploration. Exploitation relates more strongly to IJV new product performance when partner product similarity is high, whereas exploration has a stronger impact on IJV new product performance at low levels of partner product similarity. These findings provide novel insights for IJVs to better manage exploitation and exploration in their new product development.
Self-Curing Concrete under Sulfate Attack
Authors: Bashandy A. A.
Published: August 2016

Self-curing concrete SC is a concrete type that can be cured without using any external curing regimes. It can perform by several methods such as using lightweight aggregate or chemical agents. In this research chemical curing agent is used to produce SC. This paper reports the results of a research study conducted to evaluate the effect of sulfates on the performance of self-curing concrete compared to ordinary concrete. Samples are immersed in sodium sulfate Na2SO4 solution of 4% concentration. Results are measured in terms of compressive strength, tensile strength, flexural strength and mass loss. It was found that the rate of strength loss is noticed at ordinary concrete compared to SC concrete. Sulfate resistance is improved when using self-curing concrete. This improvement appears to be dependent on using a chemical curing agent.
Evaluation of Microtexture Changes of Coarse Aggregate during Simulated Polishing
Authors: Gardziejczyk W. , Wasilewska M.
Published: August 2016

This paper presents application of optical microscope for evaluation of microtexture changes of coarse aggregate during simulated polishing in laboratory. Observations of the apparent changes on surfaces of seven different aggregates are presented. Simulation polishing of aggregate was performed in accordance with PN-EN 1097-8:2009. Images of the aggregate surface were taken with the optical microscope in the reflection mode in particular stages of polishing. Digital images were analyzed. Standard deviation was determined on the basis of the histogram of intensities from digital images of the surfaces of aggregate grains which was assumed as the measure of changes in microtexture during simulated polishing (namely the σn parameter). Statistical analysis has shown that the changes of the σn parameter between the particular stages of polishing confirm certain trends related to the petrographic characteristic of the rocks. Aggregates which included minerals of similar hardness (granodiorite, dolomile, basall) were more prone to polishing than gabbro and postglacial. Regeneration of the microtexture, the recovery to its original asperity, occurred in the case of quartz sandstone and steelmaking slag.
Construction Scheduling and Stability of the Resulting Schedules
Authors: Krzemiński M.
Published: August 2016

The paper present the concept of stability assessing the of solutions which are construction schedules. Rank have been obtained through the use of task scheduling rules and the application of the KASS software. The aim of the work is the choice of the equivalent solution in terms of the total time of the project. The selected solution optimization task should be characterized by the highest resistance to harmful environmental risk factors. To asses the stability of schedule simulation technique was used.
Asymptotic analysis of a class of Ginzburg–Landau equations in thin multidomains
Authors: Messaoudi Abdellatif
Published: August 2016

This paper addresses the asymptotic analysis of minimizers of the classical Ginzburg–Landau energy in a thin multidomain. More precisely we are interested in the minimization of the energy

over all maps
EPW cubes
Authors: Iliev Atanas , Kapustka Grzegorz , Kapustka Michał , Ranestad Kristian
Published: August 2016

We construct a new 20-dimensional family of projective six-dimensional irreducible holomorphic symplectic manifolds. The elements of this family are deformation equivalent with the Hilbert scheme of three points on a K3 surface and are constructed as natural double covers of special codimension-three subvarieties of the Grassmannian

G
⁢

(
3
,
6
)

G(3,6)

. These codimension-three subvarieties are defined
as Lagrangian degeneracy loci and their construction is parallel to that of EPW sextics, we call them the EPW cubes. As a consequence we prove that the moduli space of polarized IHS sixfolds of

K
⁢
3

K3

-type, Beauville–Bogomolov degree 4 and divisibility 2 is unirational.
Compact Multi-band Power Dividers Based on Stub Loaded Stepped-Impedance Resonators with Defected Microstrip Structure (SL-SIR-DMS)
Authors: Chen Lei , Wei Feng
Published: August 2016

Based on conventional Wilkinson power divider, two compact multi-band equal power dividers (PDs) employing stub loaded stepped-impedance resonators with defected microstrip structure (SL-SIR-DMS) is proposed in this paper. The proposed SL-SIR-DMS is analyzed by even/odd mode method. It is found that different defected structures can lead to different frequency responses. In addition, by using DMS, tri-band and even quad-band responses can be easily achieved without increasing the resonator size. As verification, one tri-band equal PD and one quad-band one are fabricated. The predicted results on S parameters are compared with the measured ones and good agreement is found.
Narracyjny portret Marie Grubbe w powieści lone hørslev dyrets år (rok bestii)
Authors: Cymbrykiewicz Joanna
Published: August 2016

The article A narrative portrait of Marie Grubbe in Lone Hørslev’s novel Dyrets år (The Year of the Beast) discusses the latest biographical novel on the controversial Danish aristocrat from the 17th century. In order to address the issue in closer detail, a brief biography of Marie Grubbe is given in the article’s introduction which is followed by a presentation of all the Danish works of fiction on the person that have been published so far. The analysis shows that the authors’ approach to their protagonist varies from disgust to fascination, depending on the period that the work originates from. Lone Hørslev’s Dyrets år may not be a genuine masterpiece, but it definitely adds new, contemporary aspects to the overall understanding of Marie Grubbe’s conduct and enriches her portrait with some traits which have not yet been discussed.
Analysis of Content of Selected Critical Elements in Fly Ash
Authors: Makowska Dorota , Wierońska Faustyna
Published: August 2016

Pursuant to the new mineral policy of the European Union, searching for new sources of raw materials is required. Coal fly ash has long been considered as a potential source of a number of critical elements. Therefore, it is important to monitor the contents of the critical elements in fly ash from coal combustion. The paper presents the results of examinations of the contents of selected elements, i.e. beryllium, cobalt, chromium and germanium in fly ash from Polish power plants. The results of the conducted investigations indicate that the examined ash samples from bituminous coal combustion cannot be treated as a potential source of the analysed critical elements. The content of these elements in ash, though slightly higher than their average content in the sedimentary rocks, is, however, not high enough to make their recovery technologically and economically justified at this moment.
Mountain pastures of Qilian Shan: plant communities, grazing impact and degradation status (Gansu province, NW China)
Authors: Baranova Alina , Schickhoff Udo , Wang Shunli , Jin Ming
Published: August 2016

Environmental degradation of pasture areas in the Qilian Mountains (Gansu province, NW China) has increased in recent years. Soil erosion and loss of biodiversity caused by overgrazing is widespread. Changes in plant cover, however, have not been analysed so far. The aim of this paper is to identify plant communities and to detect grazing-induced changes in vegetation patterns. Quantitative and qualitative relevé data were collected for community classification and to analyse gradual changes in vegetation patterns along altitudinal and grazing gradients. Detrended correspondence analysis (DCA) was used to analyse variation in relationships between vegetation, environmental factors and differential grazing pressure. The results of the DCA showed apparent variation in plant communities along the grazing gradient. Two factors - altitude and exposure - had the strongest impact on plant community distribution. Comparing monitoring data for the most recent nine years, a trend of pasture deterioration, plant community successions and shift in dominant species becomes obvious. In order to increase grassland quality, sustainable pasture management strategies should be implemented.
Syntaxonomy of the Festuco-Brometea class vegetation of the Azov sea coastal zone
Authors: Коlomiychuk Vitaliy , Vynokurov Denys
Published: August 2016

Syntaxonomy of the class Festuco-Brometea in Ukraine has barely been still explored. There are some scattered and local data, mainly within the Forest-Steppe zone, which need to be compiled and critically reviewed. Similarly, the Azov Sea coastal zone, which, despite the considerable diversity of habitats, remains unstudied phytosociologically. We have carried out large-scale comparisons of relevés from the Sea of Azov coastline with data from other regions of Ukraine, Europe, and Russia. In total, 2336 relevés were used for the analysis. For the analysis, Modified TWINSPAN classification was used. Diagnostic species were determined by means of the phi fidelity index. In total, 9 associations and 4 subassociations, belonging to four alliances, were identified and categorised as follows: Artemisio-Kochion prostratae (ruderalized steppes), Artemisio tauricae- Festucion valesiacae (saline steppe vegetation on sites affected by the sea or saline ground water), Stipo lessingianae-Salvion nutantis (forb-bunchgrass steppe vegetation) and Tanaceto millefolii-Galatellion villosae (bunchgrass steppes). The last alliance is proposed as a new one.
Thermal Treatment Method for Synthesis and Characterization of the Octahedral Magnetic Nanostructures of Co3O4 from a New Precursor
Authors: Gholamrezaei Sousan , Salavati-Niasari Masoud , Hadadzadeh Hassan , Behnamfar Mohammad Taghi
Published: August 2016

Magnetic Co3O4 nanostructures were synthesized via a facile thermal treatment method at 700°C by using trans-Na[Co(HMTA)2(NO2)4].H2O as a new precursor. In synthetic process Co-complex was prepared by the reaction of Na3[Co(NO2)6] and hexamethylenetetramine (HMTA). Results show that the target Co-complex was synthesized successfully and provides good conditions for preparation of magnetic nanostructures in a facile and surfactant-free method to prepare the octahedral nanostructures. Precursors and nanostructures were characterized by scanning electron microscope (SEM), X-ray diffraction (XRD), UV–visible, Fourier transform infrared (FTIR) spectroscopy and alternating gradient force magnetometer (AGFM). It is found that the Co3O4 nanostructures exhibit a ferromagnetic behavior with a saturation magnetization of 8.69 emu/g and a coercivity of 305.3 Oe at room temperature.
The Explanation of the Subprime Crisis According to the Austrian School: A Defense and Illustration
Authors: Fillieule Renaud
Published: August 2016

This paper aims, first of all, at showing that there is a very close correspondence between the series of events of the subprime cycle and the typical process described by the Austrian business cycle theory. It then answers to some of the main criticisms directed against the Austrian explanation of this crisis. It shows, finally, how major aspects of this cycle – housing bubble, governmental policies of credit and housing, financial innovations – can be integrated to or deduced from the Austrian explanatory framework.
Autour de Tocqueville : Raymond Boudon et la rationalité du politique
Authors: Leroux Robert
Published: August 2016

Raymond Boudon a été l’un des rares sociologues, surtout en France, à placer l’individu au centre de ses analyses. Il n’a pourtant pas été, contrairement à une idée reçue, un théoricien du choix rationnel. Dès les années 1970, alors qu’il est encore en début de carrière, il a proposé, du moins c’était son souhait, une théorie plus générale, de plus vaste portée, qui conjuguait la rationalité instrumentale et la neutralité axiologique, où le comportement des acteurs sociaux ne devenait intelligible qu’en tenant compte de ses croyances et de ses motivations. Rien de mécanique dans le social, aux yeux de Boudon, qui a sans cesse été soucieux d’inscrire sa propre démarche dans le prolongement de ce que la sociologie classique avait de meilleur à offrir. S’agissant de la rationalité du politique, ce n’est ni Marx ou Comte qui offraient les analyses les plus satisfaisantes, mais Weber et plus particulièrement Tocqueville. Ainsi, la « science politique nouvelle » de l’auteur de La Démocratie en Amérique, permettait à Boudon de mieux comprendre la démocratie et le libéralisme, de même qu’elle mettait en lumière les possibles dérapages du relativisme.
Rational Irrationality Across Institutional Contexts
Authors: Murphy Ryan H.
Published: August 2016

This paper considers how Bryan Caplan’s concept of rational irrationality may manifest in various political institutional arrangements, building off the demand curve for irrationality. Mob democracy, anarchy, autocracy, and constitutionally constrained democracy are the governance structures addressed. While anarchy is strictly better than mob democracy, under certain conditions, democracy, anarchy, or constitutionally constrained democracy may yield the best outcomes depending on the circumstances.
Satellite Based Analysis of Surface Urban Heat Island Intensity
Authors: Gémes Orsolya , Tobak Zalán , Leeuwen Boudewijn van
Published: August 2016

The most obvious characteristics of urban climate are higher air and surface temperatures compared to rural areas and large spatial variation of meteorological parameters within the city. This research examines the long term and seasonal development of urban surface temperature using satellite data during a period of 30 years and within a year. The medium resolution Landsat data were (pre)processed using open source tools. Besides the analysis of the long term and seasonal changes in land surface temperature within a city, also its relationship with changes in the vegetation cover was investigated. Different urban districts and local climate zones showed varying strength of correlation. The temperature difference between urban surfaces and surroundings is defined as surface urban heat island (SUHI). Its development shows remarkable seasonal and spatial anomalies. The satellite images can be applied to visualize and analyze the SUHI, although they were not collected at midday and early afternoon, when the phenomenon is normally at its maximum. The applied methodology is based on free data and software and requires minimal user interaction. Using the results new urban developments (new built up and green areas) can be planned, that help mitigate the negative effects of urban climate.
More on core-2 2-groups
Authors: Wilkens Bettina
Published: August 2016

Let G be a finite 2-group with the property that

|
H
:

H
G

|
≤
2

${|H:H_{G}|\leq 2}$

for all subgroups H of G. Then G has an abelian normal subgroup of index at most 4 in G. This result represents an affirmative answer to Question 18.56 from the current edition of the Kourovka Notebook.
Natural Kinds, Social Constructions, and Ordinary Language
Authors: Mun Cecilea
Published: August 2016

I argue for the importance of clarifying the distinction between metaphysical, semantic, and meta-semantic concerns in the discourse of what Emotion is. This allows us to see that those involved in the Scientific Emotion Project and the Folk Emotion Project are in fact involved in the same project – the Science of Emotion. It also helps us understand why questions regarding the natural kind status of Emotion, as well as answers to questions regarding the value of ordinary language emotion terms or concepts to emotion research, will not help resolve the observed crisis in the Science of Emotion.
Simple sufficient conditions for starlikeness and convexity for meromorphic functions
Authors: Goswami Pranay , Bulboacă Teodor , Alqahtani Rubayyi T.
Published: August 2016

In this paper we investigate some extensions of sufficient conditions for meromorphic multivalent functions in the open unit disk to be meromorphic multivalent starlike and convex of order α. Our results unify and extend some starlikeness and convexity conditions for meromorphic multivalent functions obtained by Xu et al. [2], and some interesting special cases are given.
Does nanobiotechnology create new tools to combat microorganisms?
Authors: Zielińska-Górska Marlena K. , Sawosz Ewa , Górski Konrad , Chwalibog André
Published: August 2016

Antimicrobial resistance is still a crucial global problem related to the overuse of antibiotics and natural microorganism capability for rapid horizontal evolution. Even new generations of drugs are not able to overcome bacterial defence mechanisms. A novel solution for this immense medical challenge can be nanomaterials. Researchers indicate that modern nanoforms can effectively support and perhaps in the long-term replace traditional bactericidal agents. Because of their unique physicochemical properties, nanotechnology products can exert multiple actions against bacteria, which might be efficient against even multidrug-resistant pathogens. In this review, we discuss the documented achievements and concerns associated with broad potential applications of nanoforms in the fight against microorganisms.
Christ Was Not an Inerrantist, so Christians
Should Not Be Either: How Jesus Read His
Bible
Authors: Sydnor Jon Paul
Published: August 2016

Jesus’ interpretation of the Hebrew scriptures is skillfully eclectic, employing techniques of
rejection, interiorization, prioritization, and synthesis. The eclectic nature of Christ’s interpretation of
the Hebrew scriptures specifically precludes any ascription of the contemporary strategies of rigorism or
inerrantism to his hermeneutic. Instead, Christ’s hermeneutic is best described as situational, agapic, and
open—hence pastoral. It is situational insofar as no hermeneutical rule can predetermine how scripture
will be applied to a situation. It is agapic insofar as all texts are interpreted in service of the divine
love and repaired human relationship. It is open insofar as it: 1. is characterized by bricolage, hence
open to experimentation with a variety of resources, 2. resists any rigidly predetermined interpretative
outcome, thereby preserving openness to agapic outcomes, 3. valorizes the micronarrative, and 4. rejects
totalization. Ultimately, Jesus’ interpretation of scripture is pastoral, preferring human flourishing
through scripture to blind obedience of scripture.
The Neural System of Postdecision Evaluation in Rostral Frontal Cortex during Problem-solving Tasks
Authors: Wan Xiaohong , Cheng Kang , Tanaka Keiji
Published: August 2016

Little attention has been paid to the postdecision processing in fMRI studies with task paradigms in which there was no explicit feedback. Although late-onset BOLD responses were previously observed in the lateral frontopolar cortex after the familiar-novel decision on visually presented words, the nature of neural activations that caused the late-onset BOLD responses remained elusive. We here found, in human experts conducting complicated problem-solving tasks in their expertise domain, that the rostral frontal cortex, including the lateral frontopolar cortex, along with the anterior inferior parietal lobule, was activated only during the postdecision period, although there was no feedback. That is, these areas showed late-onset BOLD responses, and fitting of the BOLD responses with different models indicates that they were caused by neural activations that occurred after the decision. However, there was no response after performing a sensory-motor control task, and the magnitude of postdecision activations was correlated with the degree of uncertainty about the preceding decision, which suggests that the postdecision neural activations were associated with the preceding decision procedure. Furthermore, the same set of areas was more strongly activated when the subject explicitly rethought the preceding problem. These results suggest that the rostral frontal cortex, together with anterior inferior parietal lobule, comprises a network for uncertainty monitoring and exploration of alternative resolutions in postdecision evaluation. The present results thus introduce a new aspect of the functional gradient along the rostrocaudal axis in the frontal cortex.
Excessive Sensory Stimulation during Development Alters Neural Plasticity and Vulnerability to Cocaine in Mice
Authors: Ravinder Shilpa , Donckels Elizabeth A. , Ramirez Julian S. B. , Christakis Dimitri A. , Ramirez Jan-Marino , Ferguson Susan M.
Published: August 2016

Early life experiences affect the formation of neuronal networks, which can have a profound impact on brain function and behavior later in life. Previous work has shown that mice exposed to excessive sensory stimulation during development are hyperactive and novelty seeking, and display impaired cognition compared with controls. In this study, we addressed the issue of whether excessive sensory stimulation during development could alter behaviors related to addiction and underlying circuitry in CD-1 mice. We found that the reinforcing properties of cocaine were significantly enhanced in mice exposed to excessive sensory stimulation. Moreover, although these mice displayed hyperactivity that became more pronounced over time, they showed impaired persistence of cocaine-induced locomotor sensitization. These behavioral effects were associated with alterations in glutamatergic transmission in the nucleus accumbens and amygdala. Together, these findings suggest that excessive sensory stimulation in early life significantly alters drug reward and the neural circuits that regulate addiction and attention deficit hyperactivity. These observations highlight the consequences of early life experiences and may have important implications for children growing up in today’s complex technological environment.
Only a small population of adult Sertoli cells actively proliferates in culture
Authors: Kulibin Andrey Yu , Malolina Ekaterina A
Published: August 2016

Adult mammalian Sertoli cells (SCs) have been considered to be quiescent terminal differentiated cells for many years, but recently, proliferation of adult SCs was demonstratedin vitroandin vivo. We further examined mouse SC behavior in culture and found that there are two populations of adult SCs. The first population is SCs from seminiferous tubules that hardly proliferatein vitro. The second population is small and consists of SCs with atypical nuclear morphology from the terminal segments of seminiferous tubules, a transitional zone (TZ). TZ SCs multiply in culture and form colonies, display mixture of mature and immature SC characteristics, and generate cord-like structures in a collagen matrix. The specific features of TZ SCs are ACTA2 expressionin vitroand DMRT1 low levelsin vivoandin vitro. Although thein vivofunction of TZ SCs still remains unclear, this finding has significant implications for our understanding of SC differentiation and functioning in adult mammals.
Genetic Architecture of Resistance to Stripe Rust in a Global Winter Wheat Germplasm Collection
Authors: Bulli Peter , Zhang Junli , Chao Shiaoman , Chen Xianming , Pumphrey Michael
Published: August 2016

Virulence shifts in populations of Puccinia striiformis f. sp. tritici (Pst), the causal pathogen of wheat stripe rust, are a major challenge to resistance breeding. The majority of known resistance genes are already ineffective against current races of Pst, necessitating the identification and introgression of new sources of resistance. Germplasm core collections that reflect the range of genetic and phenotypic diversity of crop species are ideal platforms for examining the genetic architecture of complex traits such as resistance to stripe rust. We report the results of genetic characterization and genome-wide association analysis (GWAS) for resistance to stripe rust in a core subset of 1175 accessions in the National Small Grains Collection (NSGC) winter wheat germplasm collection, based on genotyping with the wheat 9K single nucleotide polymorphism (SNP) iSelect assay and phenotyping of seedling and adult plants under natural disease epidemics in four environments. High correlations among the field data translated into high heritability values within and across locations. Population structure was evident when accessions were grouped by stripe rust reaction. GWAS identified 127 resistance loci that were effective across at least two environments, including 20 with significant genome-wide adjusted P-values. Based on relative map positions of previously reported genes and QTL, five of the QTL with significant genome-wide adjusted P-values in this study represent potentially new loci. This study provides an overview of the diversity of Pst resistance in the NSGC winter wheat germplasm core collection, which can be exploited for diversification of stripe rust resistance in breeding programs.
The Use of Targeted Marker Subsets to Account for Population Structure and Relatedness in Genome-Wide Association Studies of Maize (Zea maysL.)
Authors: Chen Angela H , Lipka Alexander E
Published: August 2016

A typical plant genome-wide association study (GWAS) uses a mixed linear model (MLM) that includes a trait as the response variable, a marker as an explanatory variable, and fixed and random effect covariates accounting for population structure and relatedness. Although effective in controlling for false positive signals, this model typically fails to detect signals that are correlated with population structure or are located in high linkage disequilibrium (LD) genomic regions. This result likely arises from each tested marker being used to estimate population structure and relatedness. Previous work has demonstrated that it is possible to increase the power of the MLM by estimating relatedness (i.e., kinship) with markers that are not located on the chromosome where the tested marker resides. To quantify the amount of additional significant signals one can expect using this so-called K_chr model, we reanalyzed Mendelian, polygenic, and complex traits in two maize (Zea mays L.) diversity panels that have been previously assessed using the traditional MLM. We demonstrated that the K_chr model could find more significant associations, especially in high LD regions. This finding is underscored by our identification of novel genomic signals proximal to the tocochromanol biosynthetic pathway gene ZmVTE1 that are associated with a ratio of tocotrienols. We conclude that the K_chr model can detect more intricate sources of allelic variation underlying agronomically important traits, and should therefore become more widely used for GWAS. To facilitate the implementation of the K_chr model, we provide code written in the R programming language.
A Genomic Bayesian Multi-trait and Multi-environment Model
Authors: Montesinos-López Osval A , Montesinos-López Abelardo , Crossa José , Toledo Fernando H , Pérez-Hernández Oscar , Eskridge Kent M , Rutkoski Jessica
Published: August 2016

When information on multiple genotypes evaluated in multiple environments is recorded, a multi-environment single trait model for assessing genotype × environment interaction (G × E) is usually employed. Comprehensive models that simultaneously take into account the correlated traits and trait × genotype × environment interaction (T × G × E) are lacking. In this research, we propose a Bayesian model for analyzing multiple traits and multiple environments for whole-genome prediction (WGP) model. For this model, we used Half-t priors on each standard deviation term and uniform priors on each correlation of the covariance matrix. These priors were not informative and led to posterior inferences that were insensitive to the choice of hyper-parameters. We also developed a computationally efficient Markov Chain Monte Carlo (MCMC) under the above priors, which allowed us to obtain all required full conditional distributions of the parameters leading to an exact Gibbs sampling for the posterior distribution. We used two real data sets to implement and evaluate the proposed Bayesian method and found that when the correlation between traits was high (>0.5), the proposed model (with unstructured variance–covariance) improved prediction accuracy compared to the model with diagonal and standard variance–covariance structures. The R-software package Bayesian Multi-Trait and Multi-Environment (BMTME) offers optimized C++ routines to efficiently perform the analyses.
Navigating the Phenotype Frontier: The Monarch Initiative
Authors: McMurry Julie A , Köhler Sebastian , Washington Nicole L , Balhoff James P , Borromeo Charles , Brush Matthew , Carbon Seth , Conlin Tom , Dunn Nathan , Engelstad Mark , Foster Erin , Gourdine Jean-Philippe , Jacobsen Julius OB , Keith Daniel , Laraway Bryan , Xuan Jeremy Nguyen , Shefchek Kent , Vasilevsky Nicole A , Yuan Zhou , Lewis Suzanna E , Hochheiser Harry , Groza Tudor , Smedley Damian , Robinson Peter N , Mungall Christopher J , Haendel Melissa A
Published: August 2016

The principles of genetics apply across the entire tree of life. At the cellular level we share biological mechanisms with species from which we diverged millions, even billions of years ago. We can exploit this common ancestry to learn about health and disease, by analyzing DNA and protein sequences, but also through the observable outcomes of genetic differences, i.e. phenotypes. To solve challenging disease problems we need to unify the heterogeneous data that relates genomics to disease traits. Without a big-picture view of phenotypic data, many questions in genetics are difficult or impossible to answer. The Monarch Initiative (https://monarchinitiative.org) provides tools for genotype-phenotype analysis, genomic diagnostics, and precision medicine across broad areas of disease.
Development and Validation of a Method to Identify Children With Social Complexity Risk Factors
Authors: Schrager Sheree M. , Arthur Kimberly C. , Nelson Justine , Edwards Anne R. , Murphy J. Michael , Mangione-Smith Rita , Chen Alex Y.
Published: August 2016

OBJECTIVES:

We sought to develop and validate a method to identify social complexity risk factors (eg, limited English proficiency) using Minnesota state administrative data. A secondary objective was to examine the relationship between social complexity and caregiver-reported need for care coordination.

METHODS:

A total of 460 caregivers of children with noncomplex chronic conditions enrolled in a Minnesota public health care program were surveyed and administrative data on these caregivers and children were obtained. We validated the administrative measures by examining their concordance with caregiver-reported indicators of social complexity risk factors using tetrachoric correlations. Logistic regression analyses subsequently assessed the association between social complexity risk factors identified using Minnesota’s state administrative data and caregiver-reported need for care coordination, adjusting for child demographics.

RESULTS:

Concordance between administrative and caregiver-reported data was moderate to high (correlation range 0.31–0.94, all P values <.01), with only current homelessness (r = –0.01, P = .95) failing to align significantly between the data sources. The presence of any social complexity risk factor was significantly associated with need for care coordination before (unadjusted odds ratio = 1.65; 95% confidence interval, 1.07–2.53) but not after adjusting for child demographic factors (adjusted odds ratio = 1.53; 95% confidence interval, 0.98–2.37).

CONCLUSIONS:

Social complexity risk factors may be accurately obtained from state administrative data. The presence of these risk factors may heighten a family’s need for care coordination and/or other services for children with chronic illness, even those not considered medically complex.
The PSC-17: Subscale Scores, Reliability, and Factor Structure in a New National Sample
Authors: Murphy J. Michael , Bergmann Paul , Chiang Cindy , Sturner Raymond , Howard Barbara , Abel Madelaine R. , Jellinek Michael
Published: August 2016

BACKGROUND:

The Pediatric Symptom Checklist-17 (PSC-17) is a widely used, briefer version of the PSC-35, a parent-completed measure of children’s psychosocial functioning. Despite the extensive use of the PSC-17 over the past 15 years there has not been a large-scale replication of the original derivation study.

OBJECTIVE:

To examine the prevalence of positive screens, reliability, and factor structure of PSC-17 scores in a new national sample and compare them with the derivation sample.

METHODS:

Data were collected on 80 680 pediatric outpatients, ages 4 to 15 years, whose parents filled out the PSC-17 from 2006 to 2015 via the Child Health and Development Interactive System, an electronic system that presents and scores clinical measures.

RESULTS:

The rates of positive screening on the overall PSC-17 (11.6%) and on the internalizing (10.4%) and attention (9.1%) subscales were comparable to rates found in the original sample, although the rate of externalizing problems (10.2%) was lower than in the derivation study. Reliability was high (internal consistency 0.89; test–retest 0.85), and a confirmatory factor analysis provided support for the original 3-factor model.

CONCLUSIONS:

Fifteen years after the PSC-17 was derived in a large nationally representative outpatient pediatric sample, a new and larger national sample found rates of positive screening, reliability, and factor structure that were comparable. Findings from this study support the continued use of the PSC-17 clinically as a screening tool in pediatric settings and in research.
Todo se dice en música: La presencia de la estética romántica en la prensa musical porteña (Buenos Aires, 1837- 1838)
Authors: Guillamón Guillermina
Published: August 2016

El presente trabajo busca indagar en torno a la función social, política y estética que se le atribuye a la música en el diario Boletín Musical (1837) y en La Moda (1837-38). La hipótesis que guía la investigación está orientada a pensar que, valiéndose del romanticismo como paradigma de pensamiento, los diarios erigieron a la música como una práctica inclusiva, al alcance de la totalidad del pueblo, el cual se consideraba destinatario de un programa civilizador impulsado por la “nueva generación romántica”.Al discutir muchos de los supuestos de la ilustración, en tanto ideario que consideraron obsoleto, lo que realmente estaban haciendo era cuestionar los limitados alcances de las políticas culturales del gobierno precedente y, derivado de ello, afirmar su apoyo al gobernador actual, Juan Manuel de Rosas.
Presentación
Authors: Ocampo Álvarez Ángel
Published: August 2016

En este contexto aparece el volumen 6, número 1, de la revista, constituida en esta oportunidad por seis de sus habituales secciones. Por segundo año consecutivo y gracias a la cantidad importante de colaboraciones que nos siguen llegando de distintas partes de América Latina y fuera de ella, mantenemos la periodicidad semestral de la revista. No dudamos que este importante paso acaecido desde el año 2015, no tiene marcha atrás. Todo lo contrario, por los resultados, no sería de extrañar que en un futuro próximo, se cuente con los recursos debidos para acortar la periodicidad, y hacer de humanidades una revista cuatrimestral. El incremento de las colaboraciones nos está obligando a considerar de nuevo, reducir los plazos para poder satisfacer el flujo de estas. Con el proceso de indización sucede otro tanto. Hemos logrado llevar el proceso con un resultado exitoso, sobre todo si se toma en cuenta que se trata de una revista relativamente joven. Todo ello es un claro indicador de que el diagnóstico hecho en su oportunidad, sobre la necesidad del espacio que ha venido a cubrir la revista, fue acertado.
Atenção em saúde bucal: avaliação dos centros de especialidades odontológicas da Paraíba
Authors: Freitas Cláudia Helena Soares de Morais , Lemos George Azevedo , Pessoa Talitha Rodrigues Ribeiro Fernandes , Araujo Marcílio Ferreira de , Forte Franklin Delano Soares
Published: August 2016

Este estudo objetivou avaliar a Política Nacional de Saúde Bucal na atenção de média complexidade, considerando o desempenho dos Centros de Especialidades Odontológicas (CEOs) da Paraíba. Foram avaliados 19 CEOs, utilizando-se dados secundários da produção de 2007 a 2010, registrados pelo Sistema de Informação Ambulatorial do Sistema Único de Saúde (SIA/SUS). Os dados foram obtidos, tabulados e organizados de acordo com os subgrupos de procedimentos odontológicos, segundo a Portaria Ministério da Saúde/Gabinete do Ministro n° 600. O desempenho insatisfatório dos CEOs é revelador de falhas, especialmente na gestão e na organização desses serviços. O processo de avaliação é uma etapa fundamental para garantir uma melhor qualidade dos serviços à população.
O cuidado paliativo e domiciliar em países da América Latina
Authors: Simão Vilma Margarete , Mioto Regina Celia Tamaso
Published: August 2016

O artigo analisa a assistência domiciliar em saúde dos três países da América Latina com maior gasto público social per capita no ano de 2013: Brasil, Argentina e Uruguai. Trata-se de estudo documental e bibliográfico sobre o cuidado paliativo em saúde na modalidade de internação domiciliar, tendo em conta as mudanças nas famílias latinas. A análise está estruturada em dois eixos: o contexto socioeconômico das famílias latinas e as características das políticas de desospitalização. Os resultados mostram pequena disponibilidade da mulher latina para o trabalho de cuidado na família e o reforço dessa modalidade de atenção às iniquidades em saúde.
Transversalizando a rede: o matriciamento na descentralização do aconselhamento e teste rápido para HIV, sífilis e hepatites
Authors: Rocha Kátia Bones , Santos Rejane Rosaria Grecco dos , Conz Jaqueline , Silveira Ana Carolina Tittoni da
Published: August 2016

RESUMO Objetivou-se investigar como a política de descentralização do aconselhamento e teste rápido de HIV (Vírus da Imunodeficiência Humana), sífilis e hepatites foi implementada a partir do matriciamento das equipes de Atenção Básica em Porto Alegre. É um estudo qualitativo, no qual foram realizadas oito entrevistas com matriciadoras. Entre os aspectos positivos, estão a realização da capacitação dos profissionais da Atenção Básica, de interconsultas, supervisões e visitas. Essas experiências destacam a potencialidade de um trabalho mais horizontal entre os níveis de atenção especializado e básico. Entre os aspectos considerados negativos, destacam-se a ênfase na parte técnica do teste e a descontinuidade do matriciamento.
Percepções e atitudes sobre relações interprofissionais na assistência odontológica durante o pré-natal
Authors: Faquim Juliana Pereira da Silva , Frazão Paulo
Published: August 2016

RESUMO O estudo descreve percepções e atitudes de profissionais da atenção primária sobre as relações interprofissionais na assistência odontológica durante o pré-natal. Trata-se de um estudo analítico, observacional transversal, utilizando registros administrativos e entrevistas semiestruturadas abordando questões sobre hierarquia, habilidade para evitar conflitos e colaboração interprofissional. Conclui-se que, apesar da percepção geral favorável à colaboração interprofissional, recursos formais e organizacionais não estão sendo empregados, refletindo um distanciamento entre o potencial percebido pelas entrevistas e a prática apoiada pelos instrumentos utilizados nas ações de atenção ao pré-natal.
Violência psicológica em lésbicas, gays, bissexuais, travestis e transexuais no interior do Ceará, Brasil
Authors: Albuquerque Grayce Alencar , Parente Jeanderson Soares , Belém Jameson Moreira , Garcia Cintia de Lima
Published: August 2016

RESUMO Objetivou-se determinar o perfil de violência psicológica perpetrada contra Lésbicas, Gays, Bissexuais, Travestis e Transexuais (LGBTT) no interior cearense. Estudo quantitativo realizado com 316 indivíduos LGBTT nos municípios de Juazeiro do Norte e Crato, Ceará, Brasil. Evidenciou-se prevalência de violência psicológica, sendo insultos por parte dos agressores localizados longe da vítima o tipo mais comum. Os principais agressores são pessoas desconhecidas e as reações físicas, como agressões, são as principais formas de reação. Os índices de violência psicológica cometidas contra essa população são elevados; achado importante para o planejamento de estratégias para redução desse agravo.
Implantação do e-SUS AB no Distrito Sanitário IV de João Pessoa (PB): relato de experiência
Authors: Oliveira Ana Eloísa Cruz de , Lima Isis Milane Batista de , Nascimento João Agnaldo do , Coelho Hemílio Fernandes Campos , Santos Sérgio Ribeiro dos
Published: August 2016

RESUMO Os sistemas de informação têm o propósito de auxiliar os gestores nas tomadas de decisões. O e-SUS AB facilita e contribui para a organização do trabalho dos profissionais de saúde na Atenção Básica. O presente artigo tem o objetivo de apresentar o processo de implantação e desenvolvimento do e-SUS AB no Distrito Sanitário IV de João Pessoa (PB), em 2014. Trata-se de um estudo descritivo, na forma de relato de experiência, o qual aponta as dificuldades e qualidades do sistema. Conclui-se que os esforços para reestruturação do sistema só serão efetivos com o apoio dos envolvidos na implantação, na utilização e no aprimoramento do Sistema de Informação em Saúde da Atenção Básica (Sisab) e da estratégia e-SUS AB.
Sleep Outcomes in Children with Single-Suture Craniosynostosis Compared with Unaffected Controls
Authors: Sun Baiyang , Cloonan Yona K. , Collett Brent R. , Speltz Matthew L.
Published: August 2016

Objective

To compare risk for sleep-disordered breathing between children with and without single-suture craniosynostosis.

Participants

A total of 184 children with single-suture craniosynostosis and 184 controls.

Main Outcome Measures

Parent reported sleep-disordered breathing-related symptoms.

Results

Current sleep problems were reported in 19% of patients with single-suture craniosynostosis and 14% of controls (adjusted odds ratio = 1.6; 95% CI, 0.9 to 2.8). Ever having sleep problems was reported in 25% and 23% of cases and controls, respectively (adjusted odds ratio = 1.2; 95% CI, 0.7 to 1.9). Overall, snoring was statistically associated with single-suture craniosynostosis ( P = .01) and was more often reported as 2+ nights per week (versus never) in patients with single-suture craniosynostosis (13%) than in controls (4%) (adjusted odds ratio = 3.5; 95% CI, 1.5 to 8.2).

Conclusions

Though preliminary, increased presence of snoring during sleep in children with single-suture craniosynostosis compared with controls suggests that children with isolated single-suture craniosynostosis may be at increased risk for sleep-disordered breathing. Further study using standardized assessments of sleep-disordered breathing is needed.
Formal, Figural, and Historical: On the Limits of Argumentativity
Authors: Feldman Karen S.
Published: August 2016

Over lunch with two philosophy professors, i asked their views of what i understood to be a central ambiguity in kant's Critique of Judgment. The question proved controversial for reasons I had not anticipated. One of my interlocutors grew agitated.