bluuebunny/crossref_metadata_2025 huggingface dataset:
Synthesis of Hydrotalcites from Waste Steel Slag with [Bmim]OH Intercalated for the Transesterification of Glycerol Carbonate
Authors: Liu Guanhao , Yang Jingyi , Xu Xinru
Published: September 2020

Ca-Mg-Al hydrotalcites were prepared by coprecipitation from Type S95 steel slag of Shanghai Baosteel Group as supports of ionic liquid in this paper. Five basic ionic liquids [Bmim][CH3COO], [Bmim][HCOO], [Bmim]OH, [Bmim]Br and ChOH were prepared and their catalytic performance on the synthesis of glycerol carbonate by transesterification between dimethyl carbonate and glycerol was investigated. The characterization results indicated that [Bmim]OH is the best ionic liquid (IL) for the transesterification reaction of glycerol carbonate. The hydrotalcites before and after intercalation by ionic liquid were characterized by XRD, FTIR, SEM, EDS and the IL were characterized by FT-IR, 13C-NMR and basicity determination via the Hammett method. The analysis results implied that the dispersion of [Bmim]OH in hydrotalcites reduced the alkali density appropriately and facilitated the generation of glycerol carbonate. The yield of glycerol carbonate and the conversion rate of glycerol reached 95.0% and 96.1%, respectively, when the molar ratio of dimethyl carbonate and glycerol was 3:1, the catalyst dosage was 3 wt%, the reaction temperature was 75 °C and the reaction time was 120 min. The layered structure of hydrotalcites increased the stability of ionic liquid intercalated in carriers, thus the glycerol conversion and the GC yield still remained 91.9% and 90.5% in the fifth reaction cycle.
Homology Modeling and Optimized Expression of Truncated IK Protein, tIK, as an Anti-Inflammatory Peptide
Authors: Song Yuyoung , Kim Minseon , Kim Yongae
Published: September 2020

Rheumatoid arthritis, caused by abnormalities in the autoimmune system, affects about 1% of the population. Rheumatoid arthritis does not yet have a proper treatment, and current treatment has various side effects. Therefore, there is a need for a therapeutic agent that can effectively treat rheumatoid arthritis without side effects. Recently, research on pharmaceutical drugs based on peptides has been actively conducted to reduce negative effects. Because peptide drugs are bio-friendly and bio-specific, they are characterized by no side effects. Truncated-IK (tIK) protein, a fragment of IK protein, has anti-inflammatory effects, including anti-rheumatoid arthritis activity. This study focused on the fact that tIK protein phosphorylates the interleukin 10 receptor. Through homology modeling with interleukin 10, short tIK epitopes were proposed to find the essential region of the sequence for anti-inflammatory activity. TH17 differentiation experiments were also performed with the proposed epitope. A peptide composed of 18 amino acids with an anti-inflammatory effect was named tIK-18mer. Additionally, a tIK 9-mer and a 14-mer were also found. The procedure for the experimental expression of the proposed tIK series (9-mer, 14-mer, and 18-mer) using bacterial strain is discussed.
Hair Growth Activity of Three Plants of the Polynesian Cosmetopoeia and Their Regulatory Effect on Dermal Papilla Cells
Authors: Hughes Kristelle , Ho Raimana , Greff Stéphane , Filaire Edith , Ranouille Edwige , Chazaud Claire , Herbette Gaëtan , Butaud Jean-François , Berthon Jean-Yves , Raharivelomanana Phila
Published: September 2020

Hair loss is becoming increasingly prevalent as dietary and living habits change. The search for natural products to limit hair loss has led to tapping into traditional cosmetic knowledge. We studied three plants of the Polynesian cosmetopoeia, Bidens pilosa, Calophyllum inophyllum and Fagraea berteroana, to determine their ability to promote hair growth. Their chemical content was characterized by liquid chromatography coupled to mass spectrometry (LC-MS). Their proliferative activity on dermal papilla cells (DPCs) was assessed via MTT assay and molecular targets were evaluated by RT-qPCR analysis of seven factors involved in the modulation of the hair cycle, CCND1, LEF1, DKK1, WNT5A PPARD, TGFΒ1, PPARD and RSPO2. Our results show that our extracts significantly increased proliferation of dermal papilla cells. Furthermore, LC-MS/MS analysis revealed a diversity of molecules, flavonoids, iridoids and organic acids, some known for hair-inducing properties. Finally, specific extracts and fractions of all three plants either upregulated CCND1, LEF1 and PPARD involved in stimulating hair follicle proliferation and/or lowered the gene expression levels of hair growth inhibiting factors, DKK1 and TGFB1. Our findings suggest that extracts from B. pilosa, C. inophyllum and F. berteroana are interesting candidates to stimulate hair growth.
The Role of Circulating Lycopene in Low-Grade Chronic Inflammation: A Systematic Review of the Literature
Authors: van Steenwijk Hidde P. , Bast Aalt , de Boer Alie
Published: September 2020

Background and aims: In recent years, it has become clear that low-grade chronic inflammation is involved in the onset and progression of many non-communicable diseases. Many studies have investigated the association between inflammation and lycopene, however, results have been inconsistent. This systematic review aims to determine the impact of circulating lycopene on inflammation and to investigate the effect of consuming tomato products and/or lycopene supplements on markers of inflammation. Methods: Eligible studies, published before March 2020, were identified from PubMed, EBSCOhost and ScienceDirect. Human studies published in English, that evaluated the effect of circulating lycopene in relation to inflammation biomarkers were screened and included. Studies assessing lycopene intake or general intake of carotenoids/antioxidants without measuring circulating lycopene, as well as those not reporting inflammation biomarkers as outcomes, were excluded. Results: Out of 80 publications identified and screened, 35 met the inclusion criteria. Results from 18 cross-sectional studies suggest that lycopene levels are adversely affected during inflammation and homeostatic imbalance. Most of the 17 included intervention studies reported increased circulating lycopene levels after tomato/lycopene supplementation, but almost no changes in inflammation biomarkers were observed. Conclusions: There is little evidence that increasing tomato intake or lycopene supplementation diminuates this inflammation. However, depletion of lycopene may be one of the first signs of low-grade inflammation. The available data thereby imply that it is beneficial to consume lycopene-rich foods occasionally to stay healthy and keep circulating lycopene at a basal level.
Development of One Pot Strategy for Hyper Production and In Vivo Evaluation of Lovastatin
Authors: Azeem Muhammad , Arshad Muhammad , Mahmood Saqib , Abrar Shazia , Zahoor Ameer Fawad , Javed Sadia , Tariq Bisma , Hayyat Khizar
Published: September 2020

The aim of this project was to improve the Aspergillus terreus strain and pretreatment of sugarcane bagasse as carrier substrate for bulk production of lovastatin, a cholesterol-lowering drug, in solid state fermentation. Sugarcane bagasse was treated with alkali (1–3% NaOH) for the conversion of complex polysaccharides into simple sugars for better utilization of carrier substrate by microorganism for maximum lovastatin production. Ethidium bromide (time of exposure 30–180 min) was used to induce mutation in Aspergillus terreus and the best mutant was selected on the basis of inhibition zone appeared on petri plates. Fermented lovastatin was quantified by high-performance liquid chromatography. The fermented lovastatin, produced by parent and mutant Aspergillus terreus strain, was checked on body weight, blood glucose and serum cholesterol, ALT, AST, HDL-C, LDL-C, TG and TC levels of rats for their cholesterol lowering capacity. Our results indicate that selected strain along with 2% NaOH treated sugar cane bagasse was best suitable for bulk production of lovastatin by fermentation and fermented lovastatin effectively lower the cholesterol level of rats.
Hybrid Cellulose–Basalt Polypropylene Composites with Enhanced Compatibility: The Role of Coupling Agent
Authors: Sergi Claudia , Sbardella Francesca , Lilli Matteo , Tirillò Jacopo , Calzolari Andrea , Sarasini Fabrizio
Published: September 2020

This study deals with the development and optimization of hybrid composites integrating microcrystalline cellulose and short basalt fibers in a polypropylene (PP) matrix to maximize the mechanical properties of resulting composites. To this aim, the effects of two different coupling agents, endowed with maleic anhydride (MA-g(grafted)-PP) and acrylic acid (AA-g-PP) functionalities, on the composite properties were investigated as a function of their amount. Tensile, flexural, impact and heat deflection temperature tests highlighted the lower reactivity and effectiveness of AA-g-PP, regardless of reinforcement type. Hybrid formulations with basalt/cellulose (15/15) and with 5 wt. % of MA-g-PP displayed remarkable increases in tensile strength and modulus, flexural strength and modulus, and notched Charpy impact strength, of 45% and 284%, 97% and 263%, and 13%, in comparison with neat PP, respectively. At the same time, the thermo-mechanical stability was enhanced by 65% compared to neat PP. The results of this study, if compared with the ones available in the literature, reveal the ability of such a combination of reinforcements to provide materials suitable for automotive applications with environmental benefits.
Resonance Raman Optical Activity Spectroscopy in Probing Structural Changes Invisible to Circular Dichroism Spectroscopy: A Study on Truncated Vitamin B12 Derivatives
Authors: Machalska Ewa , Zajac Grzegorz , Halat Monika , Wierzba Aleksandra J. , Gryko Dorota , Baranska Malgorzata
Published: September 2020

This work demonstrates resonance Raman optical activity (RROA) spectra of three truncated vitamin B12 derivatives modified within the nucleotide loop. Since truncated cobalamins possess sufficiently high rotational strength in the range of ROA excitation (532 nm), it was possible to record their spectra in the resonance condition. They showed several distinct spectral features allowing for the distinguishing of studied compounds, in contrast to other methods, i.e., UV-Vis absorption, electronic circular dichroism, and resonance Raman spectroscopy. The improved capacity of the RROA method is based here on the excitation of molecules via more than two electronic states, giving rise to the bisignate RROA spectrum, significantly distinct from a parent Raman spectrum. This observation is an important step in the dissemination of using RROA spectroscopy in studying the complex structure of corrinoids which may prove crucial for a better understanding of their biological role.
Peptides: Prospects for Use in the Treatment of COVID-19
Authors: Khavinson Vladimir , Linkova Natalia , Dyatlova Anastasiia , Kuznik Boris , Umnov Roman
Published: September 2020

There is a vast practice of using antimalarial drugs, RAS inhibitors, serine protease inhibitors, inhibitors of the RNA-dependent RNA polymerase of the virus and immunosuppressants for the treatment of the severe form of COVID-19, which often occurs in patients with chronic diseases and older persons. Currently, the clinical efficacy of these drugs for COVID-19 has not been proven yet. Side effects of antimalarial drugs can worsen the condition of patients and increase the likelihood of death. Peptides, given their physiological mechanism of action, have virtually no side effects. Many of them are geroprotectors and can be used in patients with chronic diseases. Peptides may be able to prevent the development of the pathological process during COVID-19 by inhibiting SARS-CoV-2 virus proteins, thereby having immuno- and bronchoprotective effects on lung cells, and normalizing the state of the hemostasis system. Immunomodulators (RKDVY, EW, KE, AEDG), possessing a physiological mechanism of action at low concentrations, appear to be the most promising group among the peptides. They normalize the cytokines’ synthesis and have an anti-inflammatory effect, thereby preventing the development of disseminated intravascular coagulation, acute respiratory distress syndrome and multiple organ failure.
Investigation on Intestinal Proteins and Drug Metabolizing Enzymes in Simulated Microgravity Rats by a Proteomics Method
Authors: Liu Huayan , Guo Jingjing , Li Yujuan , Zhang Yushi , Wang Jiaping , Gao Jianyi , Deng Yulin , Li Yongzhi
Published: September 2020

The present study aimed to investigate the change of intestinal mucosa proteins, especially the alteration of intestinal drug metabolizing enzymes (IDMEs) following 14-day simulated microgravity. Morey–Holton tail-suspension analog was used to simulate microgravity. Intestinal mucosa proteins of rats were determined by label-free quantitative proteomic strategy. A total of 335 differentially expressed proteins (DEPs) were identified, 190 DEPs were upregulated, and 145 DEPs were downregulated. According to bioinformatic analysis, most of DEPs exhibited hydrolase, oxidoreductase, transferase, ligase, or lyase catalytic activity. DEPs were mainly enriched in metabolic pathways, including metabolism of amino acid, glucose, and carbon. Moreover, 11 of DEPs were involved in exogenous drug and xenobiotics metabolism. Owing to the importance of IDMEs for the efficacy and safety of oral drugs, the expression of cytochrome P450 1A2 (CYP1A2), CYP2D1, CYP3A2, CYP2E1, alcohol dehydrogenase 1 (ADH1), and glutathione S-transferase mu 5 (GSTM5) in rat intestine mucosa was determined by Western-blot. The activity of ADH, aldehyde dehydrogenase (ALDH) and GST was evaluated. Compared with control rats, the expression of CYP1A2, CYP2D1, CYP3A2, and ADH1 in the simulated microgravity (SMG) group of rats were dramatically decreased by 33.16%, 21.93%, 48.49%, and 22.83%, respectively. GSTM5 was significantly upregulated by 53.14% and CYP2E1 expression did not show a dramatical change in SMG group rats. Moreover, 14-day SMG reduced ADH activity, while ALDH and GST activities was not altered remarkably. It could be concluded that SMG dramatically affected the expression and activity of some IDMEs, which might alter the efficacy or safety of their substrate drugs under microgravity. The present study provided some preliminary information on IDMEs under microgravity. It revealed the potential effect of SMG on intestinal metabolism, which may be helpful to understand the intestinal health of astronauts and medication use.
New Insights on the Feature and Function of Tail Tubular Protein B and Tail Fiber Protein of the Lytic Bacteriophage φYeO3-12 Specific for Yersinia enterocolitica Serotype O:3
Authors: Pyra Anna , Filik Karolina , Szermer-Olearnik Bożena , Czarny Anna , Brzozowska Ewa
Published: September 2020

For the first time, we are introducing TTPBgp12 and TFPgp17 as new members of the tail tubular proteins B (TTPB) and tail fiber proteins (TFP) family, respectively. These proteins originate from Yersinia enterocolitica phage φYeO3-12. It was originally thought that these were structural proteins. However, our results show that they also inhibit bacterial growth and biofilm formation. According to the bioinformatic analysis, TTPBgp12 is functionally and structurally similar to the TTP of Enterobacteria phage T7 and adopts a β-structure. TFPgp17 contains an intramolecular chaperone domain at its C-terminal end. The N-terminus of TFPgp17 is similar to other representatives of the TFP family. Interestingly, the predicted 3D structure of TFPgp17 is similar to other bacterial S-layer proteins. Based on the thermal unfolding experiment, TTPBgp12 seems to be a two-domain protein that aggregates in the presence of sugars such as maltose and N-acetylglucosamine (GlcNAc). These sugars cause two unfolding events to transition into one global event. TFPgp17 is a one-domain protein. Maltose and GlcNAc decrease the aggregation temperature of TFPgp17, while the presence of N-acetylgalactosamine (GalNAc) increases the temperature of its aggregation. The thermal unfolding analysis of the concentration gradient of TTPBgp12 and TFPgp17 indicates that with decreasing concentrations, both proteins increase in stability. However, a decrease in the protein concentration also causes an increase in its aggregation, for both TTPBgp12 and TFPgp17.
Bifunctional HDAC Therapeutics: One Drug to Rule Them All?
Authors: Smalley Joshua P. , Cowley Shaun M. , Hodgkinson James T.
Published: September 2020

Histone deacetylase (HDAC) enzymes play crucial roles in epigenetic gene expression and are an attractive therapeutic target. Five HDAC inhibitors have been approved for cancer treatment to date, however, clinical applications have been limited due to poor single-agent drug efficacy and side effects associated with a lack of HDAC isoform or complex selectivity. An emerging strategy aiming to address these limitations is the development of bifunctional HDAC therapeutics—single molecules comprising a HDAC inhibitor conjugated to another specificity targeting moiety. This review summarises the recent advancements in novel types of dual-targeting HDAC modulators, including proteolysis-targeting chimeras (PROTACs), with a focus on HDAC isoform and complex selectivity, and the future potential of such bifunctional molecules in achieving enhanced drug efficacy and therapeutic benefits in treating disease.
Sericin-Induced Melanogenesis in Cultured Retinal Pigment Epithelial Cells Is Associated with Elevated Levels of Hydrogen Peroxide and Inflammatory Proteins
Authors: Khan Ayyad Zartasht , Jackson Catherine Joan , Utheim Tor Paaske , Reppe Sjur , Sapkota Dipak , Olstad Ole Kristoffer , Thiede Bernd , Eidet Jon Roger
Published: September 2020

We previously demonstrated that the silk protein sericin promotes pigmentation of retinal pigment epithelium (RPE) by activating the NF-κB pathway. Among numerous agents, NF-κB can be activated by hydrogen peroxide. In the present study, we explored possible associations between reactive oxygen species and sericin-induced melanogenesis in RPE. The proteome of human fetal RPE cultured for seven days with or without 1% sericin was analyzed using ingenuity pathway analysis (IPA). The proteomic data was verified by immunofluorescence and immunoblotting. Light microscopy and scanning electron microscopy were used to assess morphology. Dihydroethidium (DHE) and dihydrorhodamine (DHR) assays were used to measure superoxide and hydrogen peroxide species. Expression levels of proteins related to inflammation, differentiation, cell survival and cell adhesion were higher in cells cultured in Dulbecco’s Modified Eagle Medium (DMEM) with 1% sericin, whereas cells cultured in DMEM alone showed higher expression levels of proteins associated with Bruch’s membrane and cytoskeleton. Despite upregulation of inflammatory proteins, sericin co-cultured RPE yielded significantly higher cell viability compared to cells cultured without sericin. Addition of sericin to culture media significantly increased hydrogen peroxide-levels without significantly affecting superoxide-levels. We suggest that sericin-induced melanogenesis in cultured RPE is associated with elevated levels of superoxide dismutase, hydrogen peroxide and inflammatory proteins.
Application of a Flow-Induced Stress Wave and Investigation of Associated Injuries on Cell Monolayers Using a Parallel Plate Flow Chamber
Authors: Shurbaji Samar , Al-Ruweidi Mahmoud Khatib A. A. , Ali Fatma Hassan , Benslimane Fatiha M. , Yalcin Huseyin C.
Published: September 2020

Parallel plate flow chambers are widely used to expose cultured cells to physiological flows for the investigation of a variety of diseases. These applications usually involve the generation of continuous and steady fluid flow over cell monolayers for extended durations, usually a few days. Another technique is to generate a fast high-stress wave over the cells to see the immediate effect of flow-induced stresses. This can be achieved by propagating an air/liquid interface, in other words, a bubble, over cell monolayers. The approach is relevant to the reopening event of fluid-filled lung bronchioles and alveoli during mechanical ventilation therapy of Acute Respiratory Distress Syndrome. This article explains how we generate a stress wave using a parallel plate flow chamber and presents representative results of this wave on cultured lung epithelial cells.
Motivational and Control Mechanisms Underlying Adolescent versus Adult Alcohol Use
Authors: Cousijn Janna , Green Kayla H. , Labots Maaike , Vanderschuren Louk J. M. J. , Kenemans J. Leon , Lesscher Heidi M. B.
Published: September 2020

Increased motivation towards alcohol use and suboptimal behavioral control are suggested to predispose adolescents to alcohol use disorders (AUDs). Paradoxically however, most adolescent AUDs resolve over time without any formal intervention, suggesting adolescent resilience to AUDs. Importantly, studies directly comparing adolescent and adult alcohol use are largely missing. We therefore aimed to unravel the moderating role of age in the relation between alcohol use and motivational and control-related cognitive processes in 45 adolescent drinkers compared to 45 adults. We found that enhancement drinking motives and impulsivity related positively to alcohol use. Although enhancement drinking motives and impulsivity were higher in adolescents, the strength of the relation between these measures and alcohol use did not differ between age groups. None of the alcohol use-related motivational measures (i.e., craving, attentional bias, and approach bias) and behavioral control measures (i.e., interference control, risky decision making, and working-memory) were associated with alcohol use or differed between age groups. These findings support the role of impulsivity and affective sensitivity in adolescent drinking but question the moderating role of age therein. The current study contributes towards understanding the role of age in the relation between alcohol use and cognition.
Continuous Pharmaceutical Manufacturing
Authors: Korhonen Ossi
Published: September 2020

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Silicon Photonic Mode-Division Reconfigurable Optical Add/Drop Multiplexers with Mode-Selective Integrated MEMS Switches
Authors: Nguyen Vinh Huu , Kim In Ki , Seok Tae Joon
Published: September 2020

Mode-division multiplexing (MDM) is an attractive solution for future on-chip networks to enhance the optical transmission capacity with a single laser source. A mode-division reconfigurable optical add/drop multiplexer (ROADM) is one of the key components to construct flexible and complex on-chip optical networks for MDM systems. In this paper, we report on a novel scheme of mode-division ROADM with mode-selective silicon photonic MEMS (micro-electromechanical system) switches. With this ROADM device, data carried by any mode-channels can be rerouted or switched at an MDM network node, i.e., any mode could be added/dropped to/from the multimode bus waveguide flexibly and selectively. Particularly, the design and simulation of adiabatic vertical couplers for three quasi-TE modes (TE0, TE1, and TE2 modes) based on effective index analysis and mode overlap calculation method are reported. The calculated insertion losses are less than 0.08 dB, 0.19 dB, and 0.03 dB for the TE0 mode, TE1 mode, and TE2 mode couplers, respectively, over a wavelength range of 75 nm (1515–1590 nm). The crosstalks are below −20 dB over the bandwidth. The proposed device is promising for future on-chip optical networks with flexible functionality and large-scale integration.
Near- and Far-Field Excitation of Topological Plasmonic Metasurfaces
Authors: Proctor Matthew , Xiao Xiaofei , Craster Richard , Maier Stefan , Giannini Vincenzo , Arroyo Huidobro Paloma
Published: September 2020

The breathing honeycomb lattice hosts a topologically non-trivial bulk phase due to the crystalline-symmetry of the system. Pseudospin-dependent edge states, which emerge at the interface between trivial and non-trivial regions, can be used for the directional propagation of energy. Using the plasmonic metasurface as an example system, we probe these states in the near- and far-field using a semi-analytical model. We provide the conditions under which directionality was observed and show that it is source position dependent. By probing with circularly-polarised magnetic dipoles out of the plane, we first characterise modes along the interface in terms of the enhancement of source emissions due to the metasurface. We then excite from the far-field with non-zero orbital angular momentum beams. The position-dependent directionality holds true for all classical wave systems with a breathing honeycomb lattice. Our results show that a metasurface in combination with a chiral two-dimensional material, could be used to guide light effectively on the nanoscale.
Solubilization, Hansen Solubility Parameters, Solution Thermodynamics and Solvation Behavior of Flufenamic Acid in (Carbitol + Water) Mixtures
Authors: Shakeel Faiyaz , Alshehri Sultan
Published: September 2020

The solubilization, solution thermodynamics, solvation behavior and Hansen solubility parameters (HSPs) of an anti-inflammatory medicine flufenamic acid (FFA) in various Carbitol + water mixtures were evaluated in this study. The experimental solubility of FFA in mole fraction (xe) was measured at T = 298.2–318.2 K and p = 0.1 MPa using a static equilibrium method. The xe values of FFA in various Carbitol + water mixtures were correlated with van’t Hoff, Apelblat, Yalkowsky–Roseman, Jouyban–Acree and Jouyban–Acree–van’t Hoff models. All the studied models showed good correlation with mean error values of less than 2%. The xe value of FFA was found to increase significantly with the increase in temperature and Carbitol mass fraction in all Carbitol + water mixtures evaluated. The maximum and minimum xe values of FFA were recorded in pure Carbitol (2.81 × 10−1) at T = 318.2 K and pure water (5.80 × 10−7) at T = 298.2 K, respectively. Moreover, the HSP of FFA was found to be more closed with that of pure Carbitol, indicating the maximum solubility of FFA in pure Carbitol. The estimated values of activity coefficients showed higher molecular interactions in FFA–Carbitol combinations compared with FFA–water combinations. Thermodynamic studies indicated an endothermic and entropy-driven dissolution of FFA in all Carbitol + water mixtures. The solvation behavior of FFA was observed as enthalpy driven in all Carbitol + water combinations evaluated.
Shifting to Remotely Delivered Mental Health Care: Quality Improvement in the COVID-19 Pandemic
Authors: Daigle Patrick , Rudnick Abraham
Published: September 2020

This paper presents an organizational (ambulatory) case study of shifting mental health care from in-person to remote service delivery due to the current (COVID-19) pandemic as a rapid quality improvement initiative. Remotely delivered mental health care, particularly using synchronous video and phone, has been shown to be cost-effective, especially for rural service users. Our provincial specialized mental health clinic rapidly shifted to such remote delivery during the current pandemic. We report on processes and outputs of this rapid quality improvement initiative, which serves a purpose beyond pandemic circumstances, such as improving access to such specialized mental health care for rural and other service users at any time. In conclusion, shifting specialized mental health care from in-person to remotely delivered services as much as possible could be beneficial beyond the current pandemic. More research is needed to optimize the implementation of such a shift.
A Portable Support Attitude Sensing System for Accurate Attitude Estimation of Hydraulic Support Based on Unscented Kalman Filter
Authors: Lu Xuliang , Wang Zhongbin , Tan Chao , Yan Haifeng , Si Lei , Wei Dong
Published: September 2020

To measure the support attitude of hydraulic support, a support attitude sensing system composed of an inertial measurement unit with microelectromechanical system (MEMS) was designed in this study. Yaw angle estimation with magnetometers is disturbed by the perturbed magnetic field generated by coal rock structure and high-power equipment of shearer in automatic coal mining working face. Roll and pitch angles are estimated using the MEMS gyroscope and accelerometer, and the accuracy is not reliable with time. In order to eliminate the measurement error of the sensors and obtain the high-accuracy attitude estimation of the system, an unscented Kalman filter based on quaternion according to the characteristics of complementation of the magnetometer, accelerometer and gyroscope is applied to optimize the solution of sensor data. Then the gradient descent algorithm is used to optimize the key parameter of unscented Kalman filter, namely process noise covariance, to improve the accuracy of attitude calculation. Finally, an experiment and industrial application show that the average measurement error of yaw angle is less than 2° and that of pitch angle and roll angle is less than 1°, which proves the efficiency and feasibility of the proposed system and method.
Exploring the Impact of Medical Brain Drain on Child Health in 188 Countries over 2000–2015
Authors: Quamruzzaman Amm
Published: September 2020

Medical brain drain has been a policy concern in recent years when many countries are struggling with health workforce shortages. Some suggest that wealthy countries only exacerbate this problem by recruiting internationally trained health professionals. Little research has considered the impact of medical brain drain on child health in the sending society, and the few empirical analyses that exist find no conclusive evidence. To fill this gap, I test the underlying mechanisms through which medical brain drain may affect child health in scores of countries. I use a panel dataset covering 188 countries over the period 2000–2015. The findings from fixed-effects regression models suggest that medical brain drain negatively affects child health and that there is a curvilinear relationship between the two. The effects on child health are stronger in countries approximately in the middle of the medical brain drain scale, and weaker on both ends. The implications of the findings for policy and future research are highlighted.
Combine MCDM Methods and PSO to Evaluate Economic Benefits of High-Tech Zones in China
Authors: Yu Xiaobing , Wu Xuejing , Huo Tongzhao
Published: September 2020

High-tech zones (HTZs), as important economic growth poles, have played a key role in China’s economic boom. A method based on multi-criteria decision-making (MCDM) and particle swarm optimization (PSO) is proposed to evaluate economic benefits of HTZs. MCDM involves analytic hierarchy process (AHP) and technique for order preference by similarity to an ideal solution (TOPSIS) as they are easy and simple to calculate. AHP is used to construct judgment matrix. Then, the judgment matrix is converted to a constraint optimization problem. PSO is adopted to optimize the problem and get weights of indicators. TOPSIS is used to make the evaluation. The results from 2012 to 2016 of 105 HTZs are obtained and hierarchical clustering analysis is applied to cluster results. The results have demonstrated that the rankings of Zhongguancun Technology Park and Wuhan East Lake HTZ have always been at the forefront, and the ranking of Kunshan New District has risen rapidly, while Shenyang HTZ has dropped significantly. According to the results, some targeted suggestions have been proposed for the development of HTZs.
Impact and Acting Path of Carbon Emission Trading on Carbon Emission Intensity of Construction Land: Evidence from Pilot Areas in China
Authors: Li Lu , Dong Jie , Song Yan
Published: September 2020

Recently, the environmental and resource crisis caused by excessive energy consumption has aroused great concern worldwide. China is a major country of energy consumption and carbon emissions, and has attempted to build a carbon emission trading market to reduce carbon emissions. This practice helps to promote the carbon trading projects for both regional carbon emission reduction and sustainable development in the pilot areas, as well as having important theoretical and practical significance for the further improvement of carbon emission trading policies. In this study, we first used the difference-in-difference (DID) model to evaluate the impact of carbon emission trading on the carbon emission intensity of construction land (CEICL). The results showed that the carbon emission trading policy can significantly reduce CEICL in the pilot areas. Furthermore, we adopted the quantile regression model to explore the mechanism and acting path of carbon emission trading on CEICL. The results show that the increase in carbon trading volume (CTV) can effectively reduce the CEICL. However, a high carbon trading price (CTP) tends to reduce the suppressing effect of carbon emission trading on CEICL. Additionally, carbon emission trading also affects CEICL through the indirect acting paths of industrial structure and energy intensity. Finally, we propose to promote regional low-carbon development from the perspective of developing a carbon emission trading market nationwide, rationalizing the carbon quota and trading price mechanism, optimizing the regional industrial structure, and improving the energy consumption structure.
SiSMI Project–Technologies for the Improvement of Safety and the Reconstruction of Historic Centres in the Seismic Area of Central Italy
Authors: Imbroglini Cristina , Caravaggi Lucina , Spita Leone
Published: September 2020

The project SISMI-Tecnologie per il miglioramento della Sicurezza e la ricostruzione dei centri Storici in area sisMIca (technologies for the improvement of safety and the reconstruction of historic centres in the seismic area)–aims to provide tools and methods for risk reduction and seismic improvement of Lazio’s cultural assets and centres, causing research, intervention policies, and planning to interact in order to support reconstruction choices and foster dialogue with local parties and enterprises. One of the SISMI project’s main elements of innovation consists of preparing modes of integration of knowledge and assessments relating to the various components of a territory’s vulnerability and seismic hazard that can be used in other seismic territories. SISMI project, tested in seismic territories of Central Italy, is a methodology of integrated, multidimensional, and transdisciplinary investigation, in the conviction that the safety of the territory and of historic and cultural assets is the result of a dynamic risk reduction process capable of guaranteeing and promoting the local communities’ resilience, in which both physical/structural and sociocultural elements collaborate.
Unequal Loneliness in the Digitalized Classroom: Two Loneliness Effects of School Computers and Lessons for Sustainable Education in the E-Learning Era
Authors: Ahn Jongseok
Published: September 2020

Incorporating information and communication technology (ICT) into schooling has been one of the most conspicuous trends in education innovation for decades. Despite the education community’s optimistic consensus on the digitalization of the classroom, however, evidence-based research on the educational effectiveness of ICT is an unfinished task. In this situation, this study gives renewed attention to the socioemotional effects of school computers and draws lessons for sustainable education in the e-learning era. By analyzing the Trends in International Mathematics and Science Study (TIMSS) 2015, this study identifies the causal link between school computer usage time (the independent variable) and satisfaction with peer relationships (the dependent variable) among elementary and middle school students: the loneliness deepening effect. Then, considering the issue of digital divide, it finds the positive interaction between the independent variable and academic performance (the moderating variable): the loneliness inequality effect. These two findings—summarized by the term “unequal loneliness”—call for critical reflections on the current use of school computers but do not support the Ludditish claim that wholly denies ICT’s educational values and potentials. Rather, the existence of the loneliness inequality effect additionally implies an opportunity to go beyond mere technological determinism and deliberate on human users’ capabilities for effective ICT usage.
Modelling, Measuring, and Visualising Community Resilience: A Systematic Review
Authors: Nguyen Hoang Long , Akerkar Rajendra
Published: September 2020

The concept of community resilience receives much attention in studies and applications due to its ability to provide preparedness against hazards, to protect our life against risks, and to recover to stable living conditions. Nevertheless, community resilience is complex, contextual, multifaceted, and therefore hard to define, recognise, and operationalise. An essential advantage of having a complete process for community resilience is the capacity to be aware of and respond appropriately in times of adversity. A three-step process constituting of modelling, measurement, and visualisation is crucial to determine components, to assess value, and to represent information of community resilience, respectively. The goal of this review is to offer a general overview of multiple perspectives for modelling, measuring, and visualising community resilience derived from related and emerging studies, projects, and tools. By engaging throughout the entire process, which involves three sequential steps as we mentioned above, communities can discover important components of resilience, optimise available local and natural resources, and mitigate the impact of impairments effectively and efficiently. To this end, we conduct a systematic review of 77 different literature records published from 2000 to 2020, concentrating on five research questions. We believe that researchers, practitioners, and policymakers can utilise this paper as a potential reference and a starting point to surpass current hindrances as well as to sharpen their future research directions.
Enhancing the Oxygen Barrier Properties of Nanocellulose at High Humidity: Numerical and Experimental Assessment
Authors: H. Tayeb Ali , Tajvidi Mehdi , Bousfield Douglas
Published: September 2020

Films formed from cellulose nanofibrils (CNFs) are known to be good barrier materials against oxygen, but they lose this feature once placed in humid conditions. To tackle this issue, we applied an optimized pressing condition under elevated temperature to increase the films’ density and improve their barrier performance. Furthermore, a water barrier coating was employed on the surfaces to control the moisture uptake at high relative humidity (RH). Neat self-standing films of CNF with the basis weight of 70 g/m2 were made through a filtration technique and pressed for 1 hour at 130 °C. The resulting nanostructures were covered on both sides using a water-borne barrier layer. Hot-pressing resulted in a significant reduction in oxygen transmission rate (OTR) values, from 516.7 to 3.6 (cm3/(m2·day)) and to some degree, helped preserve the reduced oxygen transmission at high relative humidity. Introducing 35 g/m2 of latex coating layer on both sides limited the films’ swelling at 90% RH for about 4 h and maintained the OTR at the same level. A finite element model was used to predict the dynamic uptake of water into the systems. The model was found to over-predict the rate of water uptake for uncoated samples but gave the correct order of magnitude results for samples that were coated. The obtained data confirmed the positive effect of hot-pressing combined with coating to produce a film with low oxygen transmission rate and potential to maintain its oxygen barrier feature at high relative humidity.
The Fuzzified Natural Transformation between Categorial Functors and Its Selected Categorial Aspects
Authors: Jobczyk Krystian
Published: September 2020

The natural transformation constitutes one of the most important entity of category theory and it introduces a piece of sophisticated dynamism to the categorial structures. Each natural transformation forms a unique mapping between the so-called functors, which live between categories. In the most simple contexts, natural transformations may be recognized by commutativity of diagrams, which determine them. In fact, the natural transformation does not form any single mapping, but a pair of two components, which–together with the commutativity condition itself–introduces a kind of a symmetry to the functor diagrams. Meanwhile, the general form of the natural transformation may be predicted by means the so-called Yoneda’s lemma in each scenario based on two-valued logic. Meanwhile, the situation may be radically different if we deal with multi-diagrams (instead of the single ones) and if we exchange the two-valued scenario for a multi-valued or fuzzy one. Due to this background–the paper introduces a new concept of multi-fuzzy natural transformation. Its definition exploits the notion of fuzzy natural transformation. Moreover, a multi-fuzzy Yoneda’s lemma is formulated and proved. Finally, some references of these constructions to coding theory are elucidated in last parts of the paper.
Environmental Health and Ecological Risk Assessment of Soil Heavy Metal Pollution in the Coastal Cities of Estuarine Bay—A Case Study of Hangzhou Bay, China
Authors: Li Rongxi , Yuan Yuan , Li Chengwei , Sun Wei , Yang Meng , Wang Xiangrong
Published: September 2020

Shanghai is the major city on the north shore of Hangzhou Bay, and the administrative regions adjacent to Hangzhou Bay are the Jinshan district, Fengxian district, and Pudong new area (Nanhui district), which are the main intersection areas of manufacturing, transportation, and agriculture in Shanghai. In this paper, we collected a total of 75 topsoil samples from six different functional areas (agricultural areas (19), roadside areas (10), industrial areas (19), residential areas (14), education areas (6), and woodland areas (7)) in these three administrative regions, and the presence of 10 heavy metals (manganese(Mn), zinc(Zn), chromium(Cr), nickel(Ni), lead(Pb), cobalt(Co), cadmium(Cd), mercury(Hg), copper(Cu), and arsenic(As)) was investigated in each sample. The Nemerow pollution index (NPI), pollution load index (PLI), and potential ecological risk index (PERI) were calculated to assess the soil pollution levels. The hazard quotient (HQ) and carcinogenic risk (CR) assessment models were used to assess the human health risks posed by the concentrations of the heavy metals. The CR and HQ for adults and children in different functional areas descended in the following order: industrial areas > roadside areas > woodland areas > residential areas > education areas > agricultural areas. The HQ of Mn for children in industrial areas was higher than 1, and the risk was within the acceptable range.
Global Food Security in a Pandemic: The Case of the New Coronavirus (COVID-19)
Authors: Lugo-Morin Diosey Ramon
Published: September 2020

The world is currently experiencing a pandemic: a virus in the family Coronaviridae is causing serious respiratory infections in humans. The outbreak of novel coronavirus disease (COVID-19) was declared a pandemic by the WHO on 11 March 2020. The outbreak began in December 2019 in Wuhan, China, and has since spread throughout the world. Despite measures taken by governments throughout the world to contain and control the spread, economic disruption at the global level is imminent and will affect all economic sectors, particularly the food sector. In a post-pandemic scenario, the use of new technologies will be decisive in a new model of food commercialization. The production and distribution of food will be configured to make supply chains optimal and safe systems. Against this background, the present study aims to explore and analyze the implications of the COVID-19 pandemic for global food security.
Antimicrobial resistance pattern of Acinetobacter; a multicenter study, comparing European Committee on Antimicrobial Susceptibility Testing (EUCAST) and the Clinical and Laboratory Standards Institute (CLSI); evaluation of susceptibility testing methods for polymyxin
Authors: Afhami Shirin , Borumand Mohammad Ali , Esmailpour Bazzaz Negin , Saffar Hiva , Hadadi Azar , Jafary Nezhad Mahdi , Mirzaei Tirabadi Nahid
Published: September 2020

Introduction: Acinetobacter species in clinical isolates cause severe infections including meningitis, bloodstream infection, ventilator-associated pneumonia, and surgical site infections. Objectives: In the present study, we evaluated Acinetobacter drug resistance using both European Committee on Antimicrobial Susceptibility Testing (EUCAST) and the Clinical and Laboratory Standards Institute (CLSI) antimicrobial susceptibility test methods. Materials and Methods: Clinical specimens of 128 patients who were admitted in three referral tertiary care teaching hospitals were enrolled in 2014. Blood and other sterile fluid samples, endotracheal secretion, ulcer, urine and other clinical specimen cultures were included, and microbial resistance of Acinetobacter isolates was determined and compared with disk diffusion and E-test antimicrobial susceptibility methods, using both the EUCAST and CLSI standards. Cohen’s kappa coefficient was also reported. Results: The highest percentage of resistance (96.9%) was found for meropenem and imipenem antimicrobials, and the lowest resistance (82.8%) was found for amikacin. The highest kappa agreement coefficient was for ciprofloxacin (kappa coefficient = 0.783), and the lowest kappa was for amikacin (kappa coefficient = 0.21). Conclusion: According to the results, it is better to consider amikacin as a choice in combination with another effective antimicrobial for treatment of drug resistant Acinetobacter.
Estimates of mortality following COVID-19 Infection; comparison between Europe and the United States
Authors: Hamidian Jahromi Alireza , Mahmoudi Hilda
Published: September 2020

While there have been so many speculations on calculating a more accurate estimate of COVID-19 mortality since the start of this pandemic, the complexity of the issue along with differences in reporting and testing systems has prevented accurate COVID-19 mortality calculations. Some non-controlled variables affect any mortality calculation which makes real estimation of the COVID-19 mortality extremely challenging and even impossible. Here we would like to re-calculate and compare the estimated COVID-19 mortality in Europe and the United States based on the currently available reported data.