bluuebunny/crossref_metadata_2025 huggingface dataset:
Similarity Detection for Higher-Order Structure of DNA Sequences
Authors: Ngoc Anh Nguyen Thi , Hieu Ho Phan , Kiet Tran Anh , Hung Vo Trung
Published: April 2018

With the advances in data collection and storage capabilities, large amount of multidimensional dataset, known as higher-order data representation, has been generated on bioinformatics applications recently, especially in DNA sequences recognition. This paper thus proposes a mathematical modeling could be capable of the multidimensional problem of DNA similarity detection with high accuracy and reliability. To this end, the paper covers the central issues of multidimensional DNA gene expression data, including: (1) formulating multidimensional DNA data into higher-order representation; (2) recovering missing values; (3) decomposing high-order DNA data directly from their tensorial representation to extracted useful information for classification. Consequently, an exploring a novel type of third-order microarray expression, termed as gene - sample - time (GST), is presented for biological sample classification. The contributions will be distributed along two main thrusts of effectiveness; including latent modeling setting for imputing missing values based on the High-Order Kalman Filter and feature extraction based on Tensor Discriminative Feature Extraction. The experimental performance on real dataset of DNA sequences corroborates the advantages of the proposed approaches upon those of the matrix-based algorithms and recent tensor-based, discriminant-decomposition, in terms of missing values completion, classiﬁcation accuracy and computation time.
An Efficient Digital Watermarking Technique for Color Images Using Directional Transforms
Authors: Sy Nguyen Chi , Kha Ha Hoang , Hoang Nguyen Minh
Published: April 2018

This paper is concerned with a digital watermarking technique for color images based on directional transforms. Different from the traditional watermarking schemes which embed the watermarks into the spatial domain or frequency domain of the Discrete Cosine Transform (DCT) and Discrete Wavelet Transform (DWT), this paper investigates the performance of the watermarking schemes using the Fast Discrete Curvelet Transforms (FDCT) and Contourlet Transform (CT). We evaluate the performance of the watermarking schemes using the directional transforms on a standard database of color images in terms of invisibility and robustness. The performance metrics are measured by Peak Signal-to-Noise Ratio (PSNR), Normalized Correlation (NC), Structural SIMilarity (SSIM) and required time for extracting and embedding process. The experimental results reveal that watermarking schemes in the directional transform domains outperform the other schemes in DWT domains.
Joint Power Allocation and Match Access for Physical Layer Security of Heterogeneous Network
Authors: Yan Shiwei , Shang Yong , Zhang Xiguang
Published: April 2018

In this paper, we investigate the Physical Layer Security (PLS) of a multiple friendly jammers and multiple users wireless system in Device-to-Device (D2D) communications underlaying cellular networks with an eavesdropper. The aim is to maximize the increase of secrecy capacity of the entire system through optimal power allocation and jamming matching under various practical constraints. Firstly, the total increase secrecy capacity of D2D pairs with the help of jamming is derived, then we obtain optimal jamming power for each D2D pair and formulate the D2D pairs and jammers matching problem in the weighted bipartite graph via designing the Kuhn-Munkres (KM) algorithm. Finally, numerical results demonstrate that our scheme could greatly improve the secrecy performance of heterogeneous D2D and cellular networks.
Ghana and the Paradoxical Situation of Its Asylum-Seekers: Selected Grounds for Alleged Persecution in a Supposed Democratic Country
Authors: d'Orsi Cristiano
Published: April 2018

This study investigates the paradoxical situation of the relatively high number of Ghanaian nationals applying for asylum in various countries, whereas Ghana is widely recognised as having a positive record on the protection of human rights. This study analyses the requests for asylum submitted by 30 Ghanaian nationals (10 women and 20 men: generally men outnumber women in asylum applications) to seven countries (Australia, Canada, France, Ireland, New Zealand, the UK and the US) over the last 25 years.
Evaluating Typical Algorithms of Combinatorial Optimization to Solve Continuous-Time Based Scheduling Problem
Authors: Lazarev Alexander A. , Nekrasov Ivan , Pravdivets Nikolay
Published: April 2018

We consider one approach to formalize the Resource-Constrained Project Scheduling Problem (RCPSP) in terms of combinatorial optimization theory. The transformation of the original problem into combinatorial setting is based on interpreting each operation as an atomic entity that has a defined duration and has to be resided on the continuous time axis meeting additional restrictions. The simplest case of continuous-time scheduling assumes one-to-one correspondence of resources and operations and corresponds to the linear programming problem setting. However, real scheduling problems include many-to-one relations which leads to the additional combinatorial component in the formulation due to operations competition. We research how to apply several typical algorithms to solve the resulted combinatorial optimization problem: enumeration including branch-and-bound method, gradient algorithm, random search technique.
The Influence of the Characteristics of the National Business System in the Disclosure of Gender-Related Corporate Social Responsibility Practices
Authors: Oliveira Marcelle , Júnior Manuel , De Oliveira Lima Sérgio , De Freitas George
Published: April 2018

We analysed the influence of the characteristics of national business systems on the disclosure of gender-related corporate social responsibility practices by 150 companies in Latin America that signed the Declaration of Support for Women’s Empowerment Principles. The highest level of disclosure was related to the establishment of high-level corporate leadership for gender equality. Results show that the country’s level of “concentration of power” and “individualism”, and the “orientation towards femininity” have a negative influence on the disclosure of gender-related practices; in addition, the country’s level of “economic development” and the “pressure of unions” exert a positive influence. The results highlight the important role that some national and local institutions play in the women’s empowerment, leading companies to report information on adopted practices. The study innovates and contributes by introducing the explanation of gender-related social disclosure with the national business system approach in Latin America.
Increasing Predictive Ability by Modeling Interactions between Environments, Genotype and Canopy Coverage Image Data for Soybeans
Authors: Jarquin Diego , Howard Reka , Xavier Alencar , Das Choudhury Sruti
Published: April 2018

Phenomics is a new area that offers numerous opportunities for its applicability in plant breeding. One possibility is to exploit this type of information obtained from early stages of the growing season by combining it with genomic data. This opens an avenue that can be capitalized by improving the predictive ability of the common prediction models used for genomic prediction. Imagery (canopy coverage) data recorded between days 14–71 using two collection methods (ground information in 2013 and 2014; aerial information in 2014 and 2015) on a soybean nested association mapping population (SoyNAM) was used to calibrate the prediction models together with the inclusion of several types of interactions between canopy coverage data, environments, and genomic data. Three different scenarios were considered that breeders might face testing lines in fields: (i) incomplete field trials (CV2); (ii) newly developed lines (CV1); and (iii) predicting lines in unobserved environments (CV0). Two different traits were evaluated in this study: yield and days to maturity (DTM). Results showed improvements in the predictive ability for yield with respect to those models that solely included genomic data. These relative improvements ranged 27–123%, 27–148%, and 65–165% for CV2, CV1, and CV0, respectively. No major changes were observed for DTM. Similar improvements were observed for both traits when the reduced canopy information for days 14–33 was used to build the training-testing relationships, showing a clear advantage of using phenomics in very early stages of the growing season.
Subunit-Specific Role of NF-κB in Cancer
Authors: Kaltschmidt Barbara , Greiner Johannes F. W. , Kadhim Hussamadin M. , Kaltschmidt Christian
Published: April 2018

The transcription factor NF-κB is a key player in inflammation, cancer development, and progression. NF-κB stimulates cell proliferation, prevents apoptosis, and could promote tumor angiogenesis as well as metastasis. Extending the commonly accepted role of NF-κB in cancer formation and progression, different NF-κB subunits have been shown to be active and of particular importance in distinct types of cancer. Here, we summarize overexpression data of the NF-κB subunits RELA, RELB, and c-REL (referring to the v-REL, which is the oncogene of Reticuloendotheliosis virus strain T) as well as of their upstream kinase inhibitor, namely inhibitor of κB kinases (IKK), in different human cancers, assessed by database mining. These data argue against a universal mechanism of cancer-mediated activation of NF-κB, and suggest a much more elaborated mode of NF-κB regulation, indicating a tumor type-specific upregulation of the NF-κB subunits. We further discuss recent findings showing the diverse roles of NF-κB signaling in cancer development and metastasis in a subunit-specific manner, emphasizing their specific transcriptional activity and the role of autoregulation. While non-canonical NF-κB RELB signaling is described to be mostly present in hematological cancers, solid cancers reveal constitutive canonical NF-κB RELA or c-REL activity. Providing a linkage to cancer therapy, we discuss the recently described pivotal role of NF-κB c-REL in regulating cancer-targeting immune responses. In addition, current strategies and ongoing clinical trials are summarized, which utilize genome editing or drugs to inhibit the NF-κB subunits for cancer treatment.
Perspective: Contribution of Epstein–Barr virus (EBV) Reactivation to the Carcinogenicity of Nasopharyngeal Cancer Cells
Authors: Wu Chung-Chun , Fang Chih-Yeu , Huang Sheng-Yen , Chiu Shih-Hsin , Lee Chia-Huei , Chen Jen-Yang
Published: April 2018

Nasopharyngeal carcinoma (NPC) is a squamous cell carcinoma derived from the epithelium of the post-nasal cavity, with a unique geographic and ethnic distribution. Epstein–Barr virus (EBV) is an etiological agent of NPC, but how it contributes to carcinogenesis is not completely clear. Although it is thought that EBV latency participates in the development of NPC, increasing evidence reveals that the lytic cycle also plays an important role in the carcinogenic process. In this review, we summarize our recent studies on how EBV reactivation causes genomic instability and accelerates tumorigenesis in epithelial cells. The roles of three lytic genes, namely, BRLF1, BGLF5 and BALF3, in this process are also introduced. Moreover, blocking EBV reactivation using natural compounds may help delay the progression of NPC tumorigenesis. These studies provide a new insight into NPC carcinogenesis and raise the possibility that inhibition of EBV reactivation may be a novel approach to prevent the relapse of NPC.
A Rationally Designed, Spiropyran-Based Chemosensor for Magnesium
Authors: Sylvia Georgina M. , Mak Adrian M. , Heng Sabrina , Bachhuka Akash , Ebendorff-Heidepriem Heike , Abell Andrew D.
Published: April 2018

Magnesium ions (Mg2+) play an important role in mammalian cell function; however, relatively little is known about the mechanisms of Mg2+ regulation in disease states. An advance in this field would come from the development of selective, reversible fluorescent chemosensors, capable of repeated measurements. To this end, the rational design and fluorescence-based photophysical characterisation of two spiropyran-based chemosensors for Mg2+ are presented. The most promising analogue, chemosensor 1, exhibits 2-fold fluorescence enhancement factor and 3-fold higher binding affinity for Mg2+ (Kd 6.0 µM) over Ca2+ (Kd 18.7 µM). Incorporation of spiropyran-based sensors into optical fibre sensing platforms has been shown to yield significant signal-to-background changes with minimal sample volumes, a real advance in biological sensing that enables measurement on subcellular-scale samples. In order to demonstrate chemosensor compatibility within the light intense microenvironment of an optical fibre, photoswitching and photostability of 1 within a suspended core optical fibre (SCF) was subsequently explored, revealing reversible Mg2+ binding with improved photostability compared to the non-photoswitchable Rhodamine B fluorophore. The spiropyran-based chemosensors reported here highlight untapped opportunities for a new class of photoswitchable Mg2+ probe and present a first step in the development of a light-controlled, reversible dip-sensor for Mg2+.
Climate Change Adaptation of Alpine Ski Tourism in Spain
Authors: Campos Rodrigues Luís , Freire-González Jaume , González Puig Aina , Puig-Ventosa Ignasi
Published: April 2018

Mountain ecosystems are considered to be vulnerable to climate change, with potential detrimental effects including the reduction of the snow seasons, the gradual retreat of glaciers, and changes in water storage and availability. One vulnerable sector to climate change is winter tourism, with some resorts likely to experience a significant reduction in the length of the skiing seasons and snow recreation areas throughout this century. This study assessed the vulnerability of 31 Spanish alpine ski resorts to climate change and evaluated the potential socio-economic and environmental implications of several adaptation measures. Results show that lower-altitude areas such as the Cantabrian Mountains and the Iberian System could be more vulnerable to climate change than higher-altitude areas of the Catalan Pyrenees or the Penibaetic System. Adaptation initiatives may include, inter alia, the production of artificial snow, the protection and conservation of the snow coverage area, and the diversification of recreation activities offered during the whole year. The study concludes that the design and implementation of adaptation strategies have to be adequate to the level of vulnerability associated with each resort as well as minimize their potential socio-economic and environmental costs.
Quantitative Analysis Using the Phototrichogram Technique of an Italian Population Suffering from Androgenic Alopecia
Authors: Brancato Sara , Cartigliani Claudia , Bonfigli Adriana , Rigano Luigi
Published: April 2018

In this study, the values of some scalp basal parameters, collected during several clinical studies involving a total of 254 subjects with androgenic alopecia, were analyzed. Subjects’ values were grouped by age and gender, and the differences between groups were examined. The density values (n° of hair/cm2) and the percentages of anagen and telogen hair were considered. Furthermore, the variations recorded at the end of cosmetic treatments (ranging from 12 to 16 weeks) aiming to reduce excessive hair loss were analyzed. The basal values regarding the percentage of hair in the anagen phase evidenced a linear decrease with increasing age, with a corresponding increase of the percentage of hair in the telogen phase. As far as the hair density differences between males and females are concerned, females had a mean value significantly higher than males. Moreover, at the end of the intended anti-hair loss treatments, females were more susceptible to improvements of their hair density values.
Genetic, Bio-Agronomic, and Nutritional Characterization of Kale (Brassica Oleracea L. var. Acephala) Diversity in Apulia, Southern Italy
Authors: Lotti Concetta , Iovieno Paolo , Centomani Isabella , Marcotrigiano Angelo R. , Fanelli Valentina , Mimiola Giancarlo , Summo Carmine , Pavan Stefano , Ricciardi Luigi
Published: April 2018

Kale (Brassica oleracea L. var. acephala) is a widely appreciated vegetable with a century-old history of cultivation in Italy. The present study was addressed to the collection and characterization of kale germplasm traditionally cultivated in Apulia, Southern Italy, nowadays at risk of genetic erosion. In total, nineteen Apulian kale accessions were acquired. Genotyping by means of simple sequence repeat (SSR) DNA markers led to the identification of highly informative primer combinations and highlighted significant patterns of molecular variation among accessions. Consistently, significant differences were observed with respect to morpho-agronomic traits, including yield and harvesting time, and the content of bioactive compounds, namely total phenols, flavonoids, and anthocyanins, associated with antioxidant activity. Overall, this study led to the establishment of an ex situ collection of great importance to preserve endangered Apulian kale germplasm and to provide seed access to potential growers. Meanwhile, it offers a first characterization of Apulian kale, useful to promote its consumption and valorisation through breeding programmes.
Percutaneous, Imaging-Guided Biopsy of Bone Metastases
Authors: Filippiadis Dimitrios , Mazioti Argyro , Kelekis Alexios
Published: April 2018

Approximately 70% of cancer patients will eventually develop bone metastases. Spine, due to the abundance of red marrow in the vertebral bodies and the communication of deep thoracic-pelvic veins with valve-less vertebral venous plexuses, is the most common site of osseous metastatic disease. Open biopsies run the risk of destabilizing an already diseased spinal or peripheral skeleton segment. Percutaneous biopsies obviate such issues and provide immediate confirmation of correct needle location in the area of interest. Indications for percutaneous bone biopsy include lesion characterization, optimal treatment and tumor recurrence identification, as well as tumor response and recurrence rate prediction. Predicting recurrence in curative cases could help in treatment stratification, identification, and validation of new targets. The overall accuracy of percutaneous biopsy is 90–95%; higher positive recovery rates govern biopsy of osteolytic lesions. The rate of complications for percutaneous biopsy approaches is <5%. The purpose of this review is to provide information about performing bone biopsy and what to expect from it as well as choosing the appropriate imaging guidance. Additionally, factors governing the appropriate needle trajectory that would likely give the greatest diagnostic yield and choice of the most appropriate biopsy system and type of anesthesia will be addressed.
Entropy Production on the Gravity-Driven Flow with Free Surface Down an Inclined Plane Subjected to Constant Temperature
Authors: Lee Jaesung
Published: April 2018

The long-wave approximation of a falling film down an inclined plane with constant temperature is used to investigate the volumetric averaged entropy production. The velocity and temperature fields are numerically computed by the evolution equation at the deformable free interface. The dynamics of a falling film have an important role in the entropy production. When the layer shows an unstable evolution, the entropy production by fluid friction is much larger than that of the film with a stable flat interface. As the heat transfers actively from the free surface to the ambient air, the temperature gradient inside flowing films becomes large and the entropy generation by heat transfer increases. The contribution of fluid friction on the volumetric averaged entropy production is larger than that of heat transfer at moderate and high viscous dissipation parameters.
A Lenient Causal Arrow of Time?
Authors: Argaman Nathan
Published: April 2018

One of the basic assumptions underlying Bell’s theorem is the causal arrow of time, having to do with temporal order rather than spatial separation. Nonetheless, the physical assumptions regarding causality are seldom studied in this context, and often even go unmentioned, in stark contrast with the many different possible locality conditions which have been studied and elaborated upon. In the present work, some retrocausal toy-models which reproduce the predictions of quantum mechanics for Bell-type correlations are reviewed. It is pointed out that a certain toy-model which is ostensibly superdeterministic—based on denying the free-variable status of some of quantum mechanics’ input parameters—actually contains within it a complete retrocausal toy-model. Occam’s razor thus indicates that the superdeterministic point of view is superfluous. A challenge is to generalize the retrocausal toy-models to a full theory—a reformulation of quantum mechanics—in which the standard causal arrow of time would be replaced by a more lenient one: an arrow of time applicable only to macroscopically-available information. In discussing such a reformulation, one finds that many of the perplexing features of quantum mechanics could arise naturally, especially in the context of stochastic theories.
A Method for Distributed Control of Reactive Power and Voltage in a Power Grid: A Game-Theoretic Approach
Authors: Idehen Ikponmwosa , Abraham Shiny , Murphy Gregory V.
Published: April 2018

The efficiency of a power system is reduced when voltage drops and losses occur along the distribution lines. While the voltage profile across the system buses can be improved by the injection of reactive power, increased line flows and line losses could result due to uncontrolled injections. Also, the determination of global optimal settings for all power-system components in large power grids is difficult to achieve. This paper presents a novel approach to the application of game theory as a method for the distributed control of reactive power and voltage in a power grid. The concept of non-cooperative, extensive = form games is used to model the interaction among power-system components that have the capacity to control reactive power flows in the system. A centralized method of control is formulated using an IEEE 6-bus test system, which is further translated to a method for distributed control using the New England 39-bus system. The determination of optimal generator settings leads to an improvement in load-voltage compliance. Finally, renewable-energy (reactive power) sources are integrated to further improve the voltage-compliance level.
Establishment and Analysis of Energy Consumption Model of Heavy-Haul Train on Large Long Slope
Authors: Lu Qiwei , He Bangbang , Wu Mingzhe , Zhang Zhichun , Luo Jiantao , Zhang Yankui , He Runkai , Wang Kunyu
Published: April 2018

AC heavy-haul trains produce a huge amount of regenerative braking energy when they run on long downhill sections. If this energy can be used by uphill trains in the same power supply section, a reduction in coal transportation cost and an improvement in power quality would result. To accurately predict the energy consumption and regenerative braking energy of heavy-haul trains on large long slopes, a single-particle model of train dynamics was used. According to the theory of railway longitudinal section simplification, the energy consumption and the regenerative braking energy model of a single train based on the train attributes, line conditions, and running speed was established. The model was applied and verified on the Shenshuo Railway. The results indicate that the percentage error of the proposed model is generally less than 10%. The model is a convenient and simple research alternative, with strong engineering feasibility. Based on this foundation, a model of train energy consumption was established under different interval lengths by considering the situation of regenerative braking energy in the multi-train operation mode. The model provides a theoretical foundation for future train diagram layout work with the goal of reducing the total train energy consumption.
Determinants and Characteristics of Korean Companies’ Carbon Management under the Carbon Pricing Scheme
Authors: Suk Sunhee
Published: April 2018

In response to the domestic emission trading scheme, Korean companies are required to shift their strategies from voluntary or regulation-driven management approaches to innovative carbon management utilizing their carbon option linked with economic value. Using a questionnaire survey targeting companies subjected to the emission trading scheme, this study explores the status of Korean companies’ carbon management in a series of five strategies and identifies the correlation between companies’ proactive carbon strategies and pre-listed determinant factors. This study found that Korean companies’ practices in accordance with carbon pricing deviate little from conventional energy and environmental management in this phase. They are likely to be affected by the need to appear socially responsible or to make a social contribution, without having to exceed this mandate in terms activities outside of this remit. Yet, only a small proportion of companies have advanced to the stage of proactive carbon management. For them, top managers’ support and understanding are essential factors together with government pressure to factor-in issues related to carbon with their business strategies. This study provides implications for policy and corporate in promoting carbon-oriented management under the carbon policy.
Simulating Forest Dynamics of Lowland Rainforests in Eastern Madagascar
Authors: Armstrong Amanda , Fischer Rico , Huth Andreas , Shugart Herman , Fatoyinbo Temilola
Published: April 2018

Ecological modeling and forecasting are essential tools for the understanding of complex vegetation dynamics. The parametric demands of some of these models are often lacking or scant for threatened ecosystems, particularly in diverse tropical ecosystems. One such ecosystem and also one of the world’s biodiversity hotspots, Madagascar’s lowland rainforests, have disappeared at an alarming rate. The processes that drive tree species growth and distribution remain as poorly understood as the species themselves. We investigated the application of the process-based individual-based FORMIND model to successfully simulate a Madagascar lowland rainforest using previously collected multi-year forest inventory plot data. We inspected the model’s ability to characterize growth and species abundance distributions over the study site, and then validated the model with an independently collected forest-inventory dataset from another lowland rainforest in eastern Madagascar. Following a comparative analysis using inventory data from the two study sites, we found that FORMIND accurately captures the structure and biomass of the study forest, with r2 values of 0.976, 0.895, and 0.995 for 1:1 lines comparing observed and simulated values across all plant functional types for aboveground biomass (tonnes/ha), stem numbers, and basal area (m2/ha), respectively. Further, in validation with a second study forest site, FORMIND also compared well, only slightly over-estimating shade-intermediate species as compared to the study site, and slightly under-representing shade-tolerant species in percentage of total aboveground biomass. As an important application of the FORMIND model, we measured the net ecosystem exchange (NEE, in tons of carbon per hectare per year) for 50 ha of simulated forest over a 1000-year run from bare ground. We found that NEE values ranged between 1 and −1 t Cha−1 year−1, consequently the study forest can be considered as a net neutral or a very slight carbon sink ecosystem, after the initial 130 years of growth. Our study found that FORMIND represents a valuable tool toward simulating forest dynamics in the immensely diverse Madagascar rainforests.
Process Variable Optimization in the Manufacture of Resorcinol–Formaldehyde Gel Materials
Authors: Prostredný Martin , Abduljalil Mohammed G. M. , Mulheran Paul A. , Fletcher Ashleigh J.
Published: April 2018

Influence of process parameters of resorcinol–formaldehyde xerogel manufacture on final gel structure was studied, including solids content, preparation/drying temperature, solvent exchange, and drying method. Xerogels produced using a range of solids content between 10 and 40 w/v% show improved textural character up to 30 w/v% with a subsequent decrease thereafter. Preparation/drying temperature shows a minimal threshold temperature of 55 °C is required to obtain a viable gel structure, with minimal impact on gel properties for further thermal increase. Improving the solvent exchange method by splitting the same amount of acetone used in this phase over the period of solvent exchange, rather than in a single application, shows an increase in total pore volume and average pore diameter, suggesting less shrinkage occurs during drying when using the improved method. Finally, comparing samples dried under vacuum and at ambient pressure, there seems to be less shrinkage when using vacuum drying compared to ambient drying, but these changes are insubstantial. Therefore, of the process parameters investigated, improved solvent exchange seems the most significant, and it is recommended that, economically, gels are produced using a solids content of 20 w/v% at a minimum temperature of 55 °C, with regular solvent replenishment in the exchange step, followed by ambient drying.
Genetic Evaluation of Natural Populations of the Endangered Conifer Thuja koraiensis Using Microsatellite Markers by Restriction-Associated DNA Sequencing
Authors: Hou Lu , Cui Yanhong , Li Xiang , Chen Wu , Zhang Zhiyong , Pang Xiaoming , Li Yingyue
Published: April 2018

Thuja koraiensis Nakai is an endangered conifer of high economic and ecological value in Jilin Province, China. However, studies on its population structure and conservation genetics have been limited by the lack of genomic data. Here, 37,761 microsatellites (simple sequence repeat, SSR) were detected based on 875,792 de novo-assembled contigs using a restriction-associated DNA (RAD) approach. Among these SSRs, 300 were randomly selected to test for polymorphisms and 96 obtained loci were able to amplify a fragment of expected size. Twelve polymorphic SSR markers were developed to analyze the genetic diversity and population structure of three natural populations. High genetic diversity (mean NA = 5.481, HE = 0.548) and moderate population differentiation (pairwise Fst = 0.048–0.078, Nm = 2.940–4.958) were found in this species. Molecular variance analysis suggested that most of the variation (83%) existed within populations. Combining the results of STRUCTURE, principal coordinate, and neighbor-joining analysis, the 232 individuals were divided into three genetic clusters that generally correlated with their geographical distributions. Finally, appropriate conservation strategies were proposed to protect this species. This study provides genetic information for the natural resource conservation and utilization of T. koraiensis and will facilitate further studies of the evolution and phylogeography of the species.
Patchoulol Production with Metabolically Engineered Corynebacterium glutamicum
Authors: Henke Nadja A. , Wichmann Julian , Baier Thomas , Frohwitter Jonas , Lauersen Kyle J. , Risse Joe M. , Peters-Wendisch Petra , Kruse Olaf , Wendisch Volker F.
Published: April 2018

Patchoulol is a sesquiterpene alcohol and an important natural product for the perfume industry. Corynebacterium glutamicum is the prominent host for the fermentative production of amino acids with an average annual production volume of ~6 million tons. Due to its robustness and well established large-scale fermentation, C. glutamicum has been engineered for the production of a number of value-added compounds including terpenoids. Both C40 and C50 carotenoids, including the industrially relevant astaxanthin, and short-chain terpenes such as the sesquiterpene valencene can be produced with this organism. In this study, systematic metabolic engineering enabled construction of a patchoulol producing C. glutamicum strain by applying the following strategies: (i) construction of a farnesyl pyrophosphate-producing platform strain by combining genomic deletions with heterologous expression of ispA from Escherichia coli; (ii) prevention of carotenoid-like byproduct formation; (iii) overproduction of limiting enzymes from the 2-c-methyl-d-erythritol 4-phosphate (MEP)-pathway to increase precursor supply; and (iv) heterologous expression of the plant patchoulol synthase gene PcPS from Pogostemon cablin. Additionally, a proof of principle liter-scale fermentation with a two-phase organic overlay-culture medium system for terpenoid capture was performed. To the best of our knowledge, the patchoulol titers demonstrated here are the highest reported to date with up to 60 mg L−1 and volumetric productivities of up to 18 mg L−1 d−1.
Evaluation of Patient and Medical Staff Satisfaction regarding Healthcare Services in Wuhan Public Hospitals
Authors: Meng Runtang , Li Jingjing , Zhang Yunquan , Yu Yong , Luo Yi , Liu Xiaohan , Zhao Yanxia , Hao Yuantao , Hu Ying , Yu Chuanhua
Published: April 2018

Satisfaction evaluation is widely used in healthcare systems to improve healthcare service quality to obtain better health outcomes. The aim of this study was to measure employee work satisfaction and patient satisfaction status in Wuhan, China. A cross-sectional study was conducted in 14 medical institutions. The final valid sample comprised a total of 696 medical staff and 668 patients. The overall satisfaction levels of medical staff and patients were 58.28 ± 14.60 (10.47–100.00) and 65.82 ± 14.66 (8.62–100.00), respectively. The factors affecting medical staff satisfaction, ranking in sequence from most to least satisfied, were: the work itself, working environment and atmosphere, hospital management, practicing environment, and job rewards. Patient satisfaction factors, from most to least affecting, were ranked as follows: physician-patient relationship and communication, service organization and facilities, continuity and collaboration of medical care, access to relevant information and support, and healthcare and related services, respectively. The overall satisfaction evaluation of medical staff was average. Healthcare policy makers and medical institution management staff should focus on job rewards and working environment. This would allow them to increase their work happiness and sense of belonging, which in turn would allow them to provide better medical services to patients. The overall patient evaluation was satisfactory, with patients satisfied at all levels of the satisfaction evaluation.
An Intuitionistic Multiplicative ORESTE Method for Patients’ Prioritization of Hospitalization
Authors: Zhang Cheng , Wu Xingli , Wu Di , Liao Huchang , Luo Li , Herrera-Viedma Enrique
Published: April 2018

The tension brought about by sickbeds is a common and intractable issue in public hospitals in China due to the large population. Assigning the order of hospitalization of patients is difficult because of complex patient information such as disease type, emergency degree, and severity. It is critical to rank the patients taking full account of various factors. However, most of the evaluation criteria for hospitalization are qualitative, and the classical ranking method cannot derive the detailed relations between patients based on these criteria. Motivated by this, a comprehensive multiple criteria decision making method named the intuitionistic multiplicative ORESTE (organísation, rangement et Synthèse dedonnées relarionnelles, in French) was proposed to handle the problem. The subjective and objective weights of criteria were considered in the proposed method. To do so, first, considering the vagueness of human perceptions towards the alternatives, an intuitionistic multiplicative preference relation model is applied to represent the experts’ preferences over the pairwise alternatives with respect to the predetermined criteria. Then, a correlation coefficient-based weight determining method is developed to derive the objective weights of criteria. This method can overcome the biased results caused by highly-related criteria. Afterwards, we improved the general ranking method, ORESTE, by introducing a new score function which considers both the subjective and objective weights of criteria. An intuitionistic multiplicative ORESTE method was then developed and further highlighted by a case study concerning the patients’ prioritization.
Air Pollution Forecasts: An Overview
Authors: Bai Lu , Wang Jianzhou , Ma Xuejiao , Lu Haiyan
Published: April 2018

Air pollution is defined as a phenomenon harmful to the ecological system and the normal conditions of human existence and development when some substances in the atmosphere exceed a certain concentration. In the face of increasingly serious environmental pollution problems, scholars have conducted a significant quantity of related research, and in those studies, the forecasting of air pollution has been of paramount importance. As a precaution, the air pollution forecast is the basis for taking effective pollution control measures, and accurate forecasting of air pollution has become an important task. Extensive research indicates that the methods of air pollution forecasting can be broadly divided into three classical categories: statistical forecasting methods, artificial intelligence methods, and numerical forecasting methods. More recently, some hybrid models have been proposed, which can improve the forecast accuracy. To provide a clear perspective on air pollution forecasting, this study reviews the theory and application of those forecasting models. In addition, based on a comparison of different forecasting methods, the advantages and disadvantages of some methods of forecasting are also provided. This study aims to provide an overview of air pollution forecasting methods for easy access and reference by researchers, which will be helpful in further studies.
Chronic Manganese Toxicity Associated with Voltage-Gated Potassium Channel Complex Antibodies in a Relapsing Neuropsychiatric Disorder
Authors: Ho Cyrus S.H. , Ho Roger C.M. , Quek Amy M.L.
Published: April 2018

Heavy metal poisoning is a rare but important cause of encephalopathy. Manganese (Mn) toxicity is especially rare in the modern world, and clinicians’ lack of recognition of its neuropsychiatric manifestations can lead to misdiagnosis and mismanagement. We describe the case of a man who presented with recurrent episodes of confusion, psychosis, dystonic limb movement and cognitive impairment and was initially diagnosed with anti-voltage-gated potassium channel (VGKC) complex limbic encephalitis in view of previous positive autoantibodies. His failure to respond to immunotherapy prompted testing for heavy metal poisoning, which was positive for Mn. This is the first report to examine an association between Mn and VGKC antibodies and the effects of Mn on functional brain activity using functional near-infrared spectroscopy (fNIRS).
Prevalence of Self-Reported Gluten-Related Disorders and Adherence to a Gluten-Free Diet in Salvadoran Adult Population
Authors: Ontiveros Noé , Rodríguez-Bellegarrigue Cecilia Ivonne , Galicia-Rodríguez Gerardo , Vergara-Jiménez Marcela de Jesús , Zepeda-Gómez Elia María , Arámburo-Galvez Jesús Gilberto , Gracia-Valenzuela Martina Hilda , Cabrera-Chávez Francisco
Published: April 2018

Gluten-related disorders are not considered of relevance at public health level in Central America. The prevalence of gluten-related disorders, and adherence to a gluten-free diet, remain unknown in the Central American region. We conducted a cross-sectional survey of the Central American population from San Salvador, El Salvador, to estimate the prevalence rates of self-reported gluten-related disorders and adherence to a gluten-free diet. 1326 individuals were surveyed. Self-reported prevalence rates were (95% Confidence Interval): gluten sensitivity 3.1% (2.3–4.2); physician-diagnosed celiac disease 0.15% (0.04–0.5); wheat allergy 0.75% (0.4–1.3); non-celiac gluten sensitivity 0.98% (0.5–1.6). The prevalence rate of adherence to a gluten-free diet was 7.0% (5.7–8.5). Seven self-reported physician diagnosed gluten-sensitive cases informed the co-existence of non-celiac gluten sensitivity with celiac disease and/or wheat allergy. Among the non-self-reported gluten sensitivity individuals following a gluten-free diet, 50% reported that they were seeing a health professional for gluten-free dietary advice. Gluten sensitivity is commonly reported in Salvadoran population, but some health professionals acknowledge the coexistence of wheat allergy, celiac disease, and non-celiac gluten sensitivity. Among studies at population level, the prevalence of adherence to a gluten-free diet in Salvadoran population is the highest reported until now. However, just a few of the gluten-free diet followers were doing it for health-related benefits; the others reported weight control and the perception that the diet is healthier as the main motivation for adopting such a diet.
A Reply to Comment on Kluckow M. Barriers to the Implementation of Newborn Pulse Oximetry Screening: A Different Perspective. Int. J. Neonatal Screen. 2018, 4(1), 4
Authors: Kluckow Martin
Published: April 2018

The commentary provided by Gentles et al. argues for the implementation of a universal pulse oximetry screening program, and I agree that, if it is possible, this is the optimum way to introduce this important health care measure for all of the reasons set out by the authors.[...]
Universal Effectiveness of Inducing Magnetic Moments in Graphene by Amino-Type sp3-Defects
Authors: Tang Tao , Wu Liting , Gao Shengqing , He Fang , Li Ming , Wen Jianfeng , Li Xinyu , Liu Fuchi
Published: April 2018

Inducing magnetic moments in graphene is very important for its potential application in spintronics. Introducing sp3-defects on the graphene basal plane is deemed as the most promising approach to produce magnetic graphene. However, its universal validity has not been very well verified experimentally. By functionalization of approximately pure amino groups on graphene basal plane, a spin-generalization efficiency of ~1 μB/100 NH2 was obtained for the first time, thus providing substantial evidence for the validity of inducing magnetic moments by sp3-defects. As well, amino groups provide another potential sp3-type candidate to prepare magnetic graphene.
Factors Influencing NO2 Adsorption/Reduction on Microporous Activated Carbon: Porosity vs. Surface Chemistry
Authors: Ghouma Imen , Jeguirim Mejdi , Limousy Lionel , Bader Najoua , Ouederni Abdelmottaleb , Bennici Simona
Published: April 2018

The textural properties and surface chemistry of different activated carbons, prepared by the chemical activation of olive stones, have been investigated in order to gain insight on the NO2 adsorption mechanism. The parent chemical activated carbon was prepared by the impregnation of olive stones in phosphoric acid followed by thermal carbonization. Then, the textural properties and surface chemistry were modified by chemical treatments including nitric acid, sodium hydroxide and/or a thermal treatment at 900 °C. The main properties of the parent and modified activated carbons were analyzed by N2-adsorption, scanning electron microscopy (SEM), and Fourier transform infrared spectroscopy (FTIR) techniques, in order to enlighten the modifications issued from the chemical and thermal treatments. The NO2 adsorption capacities of the different activated carbons were measured in fixed bed experiments under 500 ppmv NO2 concentrations at room temperature. Temperature programmed desorption (TPD) was applied after adsorption tests in order to quantify the amount of the physisorbed and chemisorbed NO2. The obtained results showed that the development of microporosity, the presence of oxygen-free sites, and the presence of basic surface groups are key factors for the efficient adsorption of NO2.
Critical Domain Problem for the Reaction–Telegraph Equation Model of Population Dynamics
Authors: Alharbi Weam , Petrovskii Sergei
Published: April 2018

A telegraph equation is believed to be an appropriate model of population dynamics as it accounts for the directional persistence of individual animal movement. Being motivated by the problem of habitat fragmentation, which is known to be a major threat to biodiversity that causes species extinction worldwide, we consider the reaction–telegraph equation (i.e., telegraph equation combined with the population growth) on a bounded domain with the goal to establish the conditions of species survival. We first show analytically that, in the case of linear growth, the expression for the domain’s critical size coincides with the critical size of the corresponding reaction–diffusion model. We then consider two biologically relevant cases of nonlinear growth, i.e., the logistic growth and the growth with a strong Allee effect. Using extensive numerical simulations, we show that in both cases the critical domain size of the reaction–telegraph equation is larger than the critical domain size of the reaction–diffusion equation. Finally, we discuss possible modifications of the model in order to enhance the positivity of its solutions.
The Role of Gut Microbiota in Obesity and Type 2 and Type 1 Diabetes Mellitus: New Insights into “Old” Diseases
Authors: Harsch Igor Alexander , Konturek Peter Christopher
Published: April 2018

The investigation of the human microbiome is the most rapidly expanding field in biomedicine. Early studies were undertaken to better understand the role of microbiota in carbohydrate digestion and utilization. These processes include polysaccharide degradation, glycan transport, glycolysis, and short-chain fatty acid production. Recent research has demonstrated that the intricate axis between gut microbiota and the host metabolism is much more complex. Gut microbiota—depending on their composition—have disease-promoting effects but can also possess protective properties. This review focuses on disorders of metabolic syndrome, with special regard to obesity as a prequel to type 2 diabetes, type 2 diabetes itself, and type 1 diabetes. In all these conditions, differences in the composition of the gut microbiota in comparison to healthy people have been reported. Mechanisms of the interaction between microbiota and host that have been characterized thus far include an increase in energy harvest, modulation of free fatty acids—especially butyrate—of bile acids, lipopolysaccharides, gamma-aminobutyric acid (GABA), an impact on toll-like receptors, the endocannabinoid system and “metabolic endotoxinemia” as well as “metabolic infection.” This review will also address the influence of already established therapies for metabolic syndrome and diabetes on the microbiota and the present state of attempts to alter the gut microbiota as a therapeutic strategy.