bluuebunny/crossref_metadata_2025 huggingface dataset:
Laboratory markers of severity across three COVID-19 outbreaks in Australia: has Omicron and vaccinations changed disease presentation?
Authors: Wang Julie , Choy Kay Weng , Lim Hui Yin , Ho Prahlad
Published: September 2022

COVID-19 has rapidly evolved since it was first discovered in December 2019. We aimed to retrospectively review our experience with COVID-19 infection across 2020–2022, focusing on differences in laboratory markers at presentation. Consecutive adult patients admitted to hospital with confirmed COVID-19 infection were retrospectively reviewed across three periods (29/3/2020–29/9/2020, 16/8/2021–13/10/2021 and 1/1/2022–31/1/2022), correlating with the lineages B.1.338, Delta (B.1.617.2) and Omicron (B.1.1.159), respectively. Laboratory findings of the first requested blood test within 24 h of presentation were recorded and correlated with patient outcome. The primary outcome was requirement for oxygen therapy at any point. Inflammatory markers, namely serum ferritin, lactate dehydrogenase (LDH), C-reactive protein (CRP) were significantly lower on presentation during 2022 compared to 2021, corresponding to a milder disease course. More than 80% of 2022 patients had received 2 or more vaccine doses and fully vaccinated patients displayed significantly lower inflammatory markers at presentation. Using 2022 data, a multivariate prediction model was constructed to predict for oxygen requirement, with c-statistic 0.86. Patients in 2022, corresponding with the Omicron variant, displayed a milder disease course, even in hospitalised patients, with the majority not requiring oxygen and lower inflammatory markers. We constructed a simple-to-use risk prediction model with c-statistic 0.86 which may identify individuals who can be safely managed as outpatients in the era of highly transmissible variants.
Self-lubricating CrAlMoN high performance tool coatings for machining of TiAl6V4
Authors: Bobzin K. , Kalscheuer C. , Carlet M. , Stachowski N. , Hintze W. , Möller C. , Ploog P.
Published: September 2022

TiAl6V4 allows significant performance improvements in industrial applications. However, the machining is a considerable challenge due to low thermal conductivity, Young’s modulus and strong adhesion tendency. This leads to high thermal and mechanical loads on the cutting edge resulting in early tool failure. Today, uncoated cemented carbide tools are commonly used. However, temperature active physical vapor deposition (PVD) coatings like CrAlVN and CrAlMoN provide a promising approach to increase tool life. For this, the coating’s ability to form lubricating oxide phases is vital. In the present study, CrAlVN and CrAlMoN coatings were investigated to determine the more suitable version for increasing the economic efficiency of machining TiAl6V4. The coatings were deposited by hybrid direct current magnetron sputtering/high power pulsed magnetron sputtering (dcMS/HPPMS) processes. Morphology, thickness, chemical composition, indentation hardness, indentation modulus and oxide phase composition were analyzed. Moreover, friction and wear behavior of the coated tools were determined using a pin on disc (PoD) tribometer at various temperatures. Additionally, tool life and deformation behavior were analyzed after turning TiAl6V4. The CrAlVN and CrAlMoN coatings show a dense morphology and a smooth surface topography. Both variants have a good adhesion to the cemented carbide tools. For increased temperatures, the tribological analyses showed a reduction in the coefficient of friction. In case of CrAlMoN coated samples, a friction reduction compared to CrAlVN was observed at lower temperatures. Due to this, an increased tool life was achieved for CrAlMoN coated cutting inserts during turning of TiAl6V4.
Application of phase-conjugate beams in beam correction and underwater optical wireless communication subject to surface wave turbulence
Authors: Li Qi , Yuan Xiuhua , Zhou Feng , Zhou Zeyu , Liu Wujie
Published: September 2022

Water surface wave turbulence is one of the factors affecting the performances of underwater optical wireless communication (UOWC) systems. In our research, a phase-conjugate beam was used to correct the beam distortion and enhance the communication performances when a system is subject to surface wave turbulence. The phase-conjugate beam was generated by a phase-conjugate mirror (PCM), and a turbulence generator was used to generate surface wave turbulence in the experiment. We calculated the beam centroid distribution and the results showed that the phase-conjugate beam had a better propagation performance than the distorted beam at the different water depths. The root mean square (RMS) of the beam centroid for the phase-conjugate beam was 11 times less than that for the distorted beam, which meant that the phase-conjugate beam could effectively correct the beam drift. We further investigated the scintillation index and the signal-to-noise ratio (SNR); the results showed that the phase-conjugate beam was able to reduce the scintillation and an obvious improvement in SNR could be obtained. This research has the potential to be applied in UWC.

Graphical Abstract
Diversity and distribution of Kinorhyncha in abyssal polymetallic nodule areas of the Clarion-Clipperton Fracture Zone and the Peru Basin, East Pacific Ocean, with the description of three new species and notes on their intraspecific variation
Authors: Sánchez Nuria , González-Casarrubios Alberto , Cepeda Diego , Khodami Sahar , Pardos Fernando , Vink Annemiek , Arbizu Pedro Martínez
Published: September 2022

Polymetallic nodule fields represent a large reservoir of undiscovered biodiversity that becomes particularly evident for meiobenthic organisms, the smallest-sized faunal group. Knowledge gaps are especially noticeable for the generally low-density metazoan groups, such as Kinorhyncha, the so-called mud dragons. Using both morphological and genetic (metabarcoding) approaches, we provide a general overview and comparison of the diversity of kinorhynchs collected during nine sampling campaigns (2016–2019) that targeted abyssal environments in several contract areas for exploration in the Clarion-Clipperton Fracture Zone (CCZ) and in the Peru Basin. Our findings from morphological analyses reveal a highly diverse mud dragon community, with 16 species present in the CCZ. Of these, 12 appear in the German contract area, including three new species described in the present contribution: Echinoderes delaordeni sp. nov., Echinoderes sanctorum sp. nov., and Echinoderes zeppilliae sp. nov. Furthermore, metabarcoding data of the kinorhynch community gathered from the area is provided, together with the geographic distribution of the known species stated per contractor area, including new records and still undescribed species. Most of the identified species in the CCZ seem to have a wide distribution, with Echinoderes sp.4 being the most common and abundant species with a distribution spreading across the CCZ and also present in the Peru Basin. Metabarcoding analyses targeting the V1V2 hypervariable region of the 18S gene from the 253 stations of the CCZ revealed 14 amplicon sequence variants (ASVs) belonging to Kinorhyncha with grade values higher than 98% detected at 15 different stations within six different areas along the CCZ. Concurring with morphology, the family Echinoderidae was the most diverse as the genus Cephalorhyncha had five ASVs, followed by Echinoderes with four ASVs. Semnoderes, however, showed the widest spread ASV, being detected at six stations. In the CCZ, the metabarcoding data showed there were no shared ASVs between the CCZ areas as well as the highest number of uniques, which was 11. Our morphological study showed a low number of specimens inhabiting nodules (surface/crevices), suggesting that specific kinorhynch species do not typically inhabit the nodules in addition to the surrounding sediment.
Onderwijs en opleiding in seksuologie en sexual medicine
Authors: Reisman Y. Cobi
Published: September 2022

Samenvatting

Hoewel patiënten en hun partners de wens hebben dat de arts het gesprek over hun seksualiteit initieert, blijven seksualiteit en intimiteit in de behandelkamer toch vaak buiten beschouwing. Dat komt vooral door gebrek aan scholing en training. Volgens de visie van de European Union of Medical Specialists (EUMS) dient iedere praktiserende medicus te beschikken over basiskennis rond seksualiteit om te begrijpen hoe seksualiteit beïnvloed kan worden door ziekte en medische interventies, over vaardigheid om seksualiteit in de anamnese te integreren en om de patiënt passend te informeren over de seksuele effecten van de voorgeschreven of voorgestelde medicatie en interventies. Er zijn echter grote verschillen in de mate aan seksuologie-onderwijs tussen de verschillende medische opleidingen en specialisaties. In dit artikel worden de aspecten van seksuologieonderwijs besproken die relevant zijn voor de uroloog en de urologische kliniek, met het doel de uroloog en zijn team hiermee bekend te maken.
Complexity and the Evolution of Consciousness
Authors: Veit Walter
Published: September 2022

This article introduces and defends the “pathological complexity thesis” as a hypothesis about the evolutionary origins of minimal consciousness, or sentience, that connects the study of animal consciousness closely with work in behavioral ecology and evolutionary biology. I argue that consciousness is an adaptive solution to a design problem that led to the extinction of complex multicellular animal life following the Avalon explosion and that was subsequently solved during the Cambrian explosion. This is the economic trade-off problem of having to deal with a complex body with high degrees of freedom, what I call “pathological complexity.” By modeling the explosion of this computational complexity using the resources of state-based behavioral and life history theory we will be able to provide an evolutionary bottom-up framework to make sense of subjective experience and its function in nature by paying close attention to the ecological lifestyles of different animals.
99mTc-labeled colloid SPECT/CT versus planar lymphoscintigraphy for sentinel lymph node detection in patients with breast cancer: a meta-analysis
Authors: Quartuccio Natale , Alongi Pierpaolo , Guglielmo Priscilla , Ricapito Rosaria , Arnone Gaspare , Treglia Giorgio
Published: September 2022

Background

The aim of this meta-analysis was to compare single-photon emission computed tomography (SPECT/CT) and planar lymphoscintigraphy (PL) in patients with primary breast cancer, undergoing lymphoscintigraphy at initial staging. Specifically, we assessed the detection rate (DR) for sentinel lymph node (SLN), the absolute number of detected SLNs by each technique, and the proportion of patients with additional SLNs detected by one technique compared to the other one. Finally, we aimed to evaluate the impact of SPECT/CT on the surgical approach.

Methods

Original articles, providing a head-to-head comparison between SPECT/CT and PL, including patients with primary breast cancer at first presentation, were searched in PubMed/MEDLINE and Scopus databases through March 31st, 2022. The DR of the imaging techniques was calculated on a per-patient analysis; studies were pooled on their odds ratios (ORs) with a random-effects model to assess the presence of a significant difference between the DRs of SPECT/CT and PL. The number of additional SLNs, calculated as relative risk (RR), and the pooled proportion of patients with additional SLNs using one imaging technique rather than the other one were investigated. The pooled ratio of surgical procedures (SLN harvesting) influenced by the use of SPECT/CT, according to the surgeons, was calculated.

Results

Sixteen studies with 2693 patients were eligible for the calculation of the DR of SPECT/CT and PL. The DR was 92.11% [95% confidence interval (95% CI) 89.32–94.50%] for SPECT/CT, and 85.12% (95% CI 80.58–89.15%) for PL, with an OR of 1.96 (95% CI 1.51–2.55) in favor of SPECT/CT. There was a relative risk of detection of larger number of SLNs (RR: 1.22, 95% CI 1.14–1.32; 12 studies; 979 patients) for SPECT/CT (n = 3983) compared to PL (n = 3321) and a significant proportion of patients with additional SLNs detected by SPECT/CT, which were missed by PL (18.88%, 95% CI: 11.72%-27.27%; 13 studies). Four articles, with a total number of 1427 patients, revealed that 23.98% of the surgical procedures benefited from the use of SPECT/CT.

Conclusions

This meta-analysis favors SPECT/CT over PL for the identification of SLN in patients with primary breast cancer at staging due to higher DR, more SLNs depicted, and a significant proportion of subjects with additional detected SLNs by SPECT/CT compared to PL. Furthermore, SPECT/CT positively influences the surgical procedure. However, PL remains a satisfactory imaging option for imaging departments not equipped with SPECT/CT due to its good patient-based DR.
Uniqueness of Solutions to Nonlinear Schrödinger Equations from their Zeros
Authors: Kehle Christoph , Ramos João P. G.
Published: September 2022

We show novel types of uniqueness and rigidity results for Schrödinger equations in either the nonlinear case or in the presence of a complex-valued potential. As our main result we obtain that the trivial solution $$u=0$$

u
=
0

is the only solution for which the assumptions $$u(t=0)\vert _{D}=0, u(t=T)\vert _{D}=0$$

u

(
t
=
0
)

|

D

=
0
,
u

(
t
=
T
)

|

D

=
0

hold, where $$D\subset \mathbb {R}^d$$

D
⊂

R

d

are certain subsets of codimension one. In particular, D is discrete for dimension $$d=1$$

d
=
1

. Our main theorem can be seen as a nonlinear analogue of discrete Fourier uniqueness pairs such as the celebrated Radchenko–Viazovska formula in [21], and the uniqueness result of the second author and M. Sousa for powers of integers [22]. As an additional application, we deduce rigidity results for solutions to some semilinear elliptic equations from their zeros.
The effect of CPAP therapy on heart rate variability in patients with obstructive sleep apnea
Authors: Grzęda-Hałon Magda , Poręba Małgorzata , Gut Gabriela , Czerwińska Karolina , Gać Paweł , Martynowicz Helena , Mazur Grzegorz , Poręba Rafał
Published: September 2022

The aim of this study was to analyze the relationship between the initiation of CPAP therapy and HRV in patients with OSA. The study group consisted of 37 patients, aged 34–79 (mean 54.95 years) with OSA treated with CPAP. Two subgroups of patients were distinguished: less than severe (AHI < 30, n = 16) and severe OSA (AHI ≥ 30, n = 21). The second study was carried out around a month after the initiation of therapy. CPAP therapy caused the improvement in polysomnographic parameters, however, in most parameters in time and frequency analysis, there were no significant positive changes in parasympathetic tone. Moreover, in HRV time analysis, the reduced rMSSD and pNN50 parameters in the hours of night rest and rMSSD and SDSD during the 15-min N3 sleep period were noted. Especially, in the group with AHI ≥ 30, we observed significant decreases in rMSSD and pNN50 for the entire time. The changes were mainly for the night periods including the N3 sleep period, which is especially connected with sleep apnea (parameters: rMSSD, SDSD, and pNN50). In spectral analysis, the decrease in HF from the 15-min daily activity period and the N3 sleep period was observed. Inverse correlations were seen between the maximum, median, and mean positive airway pressure (PAP) and the change in rMSSD, SDNN, and SDSD, mainly during night hours and the N3 sleep period. Only in patients with AHI < 30 the increase in SDNN was observed in 15-min N3 sleep period. The beneficial increase in SDNN parameter from time analysis was observed only in one sleep period in less ill patients with OSA. The lack of significant changes was observed in the majority of the parameters of heart rate variability after initiation of CPAP therapy in a short observational time; however, the shift towards reduced HRV was observed in patients with AHI > 30, so the response to CPAP therapy may depends on the severity of the apnea. The results may suggest that a longer observational period is needed in such studies, and the problem is still not fully elucidated.
Assessing the Financial Value of Decentralized Clinical Trials
Authors: DiMasi Joseph A. , Smith Zachary , Oakley-Girvan Ingrid , Mackinnon Andrew , Costello Mary , Tenaerts Pamela , Getz Kenneth A.
Published: September 2022

Background

Deployment of remote and virtual clinical trial methods and technologies, referred to collectively as decentralized clinical trials (DCTs), represents a profound shift in clinical trial practice. To our knowledge, a comprehensive assessment of the financial net benefits of DCTs has not been conducted.

Methods

We developed an expected net present value (eNPV) model of the cash flows for new drug development and commercialization to assess the financial impact of DCTs. The measure of DCT value is the increment in eNPV that occurs, on average, when DCT methods are employed in comparison to when they are not. The model is populated with parameter values taken from published studies, Tufts CSDD benchmark data, and Medable Inc. data on DCT projects. We also calculated the return on investment (ROI) in DCTs as the ratio of the increment in eNPV to the DCT implementation cost.

Results

We found substantial value from employing DCT methods in phase II and phase III trials. If we assume that DCT methods are applied to both phase II and phase III trials the increase in value is $20 million per drug that enters phase II, with a seven-fold ROI.

Conclusions

DCTs can provide substantial extra value to sponsors developing new drugs, with high returns to investment in these technologies. Future research on this topic should focus on expanding the data to larger datasets and on additional aspects of clinical trial operations not currently measured.
Achieving User-Side Fairness in Contextual Bandits
Authors: Huang Wen , Labille Kevin , Wu Xintao , Lee Dongwon , Heffernan Neil
Published: September 2022

Personalized recommendation based on multi-arm bandit (MAB) algorithms has shown to lead to high utility and efficiency as it can dynamically adapt the recommendation strategy based on feedback. However, unfairness could incur in personalized recommendation. In this paper, we study how to achieve user-side fairness in personalized recommendation. We formulate our fair personalized recommendation as a modified contextual bandit and focus on achieving fairness on the individual whom is being recommended an item as opposed to achieving fairness on the items that are being recommended. We introduce and define a metric that captures the fairness in terms of rewards received for both the privileged and protected groups. We develop a fair contextual bandit algorithm, Fair-LinUCB, that improves upon the traditional LinUCB algorithm to achieve group-level fairness of users. Our algorithm detects and monitors unfairness while it learns to recommend personalized videos to students to achieve high efficiency. We provide a theoretical regret analysis and show that our algorithm has a slightly higher regret bound than LinUCB. We conduct numerous experimental evaluations to compare the performances of our fair contextual bandit to that of LinUCB and show that our approach achieves group-level fairness while maintaining a high utility.
Motives that Mediate the Associations Between Relationship Satisfaction, Orgasmic Difficulty, and the Frequency of Faking Orgasm
Authors: Hevesi Krisztina , Horvath Zsolt , Miklos Eszter , Sal Dorottya , Rowland David L.
Published: September 2022

Introduction

Faking orgasm by women reportedly occurs quite frequently, with both relationship characteristics and orgasmic difficulty being significant predictors.

Aim

We explored women's motives that might mediate the associations between orgasmic difficulty and relationship satisfaction on the one hand, with the frequency of faking orgasm on the other.

Methods

In a study of 360 Hungarian women who reported “ever” faking orgasm during partnered sex, we assessed the direct and indirect (mediated) associations between orgasmic difficulty, relationship satisfaction, and the frequency of faking orgasm.

Outcomes

Determination of motives that mediate the association between orgasmic difficulty and the frequency of faking orgasm, and the association between relationship satisfaction and the frequency of faking orgasm.

Results

Increased orgasmic difficulty was directly related to increased frequency of faking orgasm (β = 0.37; P < .001), and each variable itself was related to a number of motives for faking orgasm. However, the only motive assessed in our study that mediated the relationship between orgasmic difficulty and the frequency of faking orgasm was insecurity about being perceived as abnormal or dysfunctional (indirect effect: β = 0.13; P < .001). A similar pattern emerged with relationship satisfaction and frequency of faking orgasm. These two variables were directly related in that lower relationship satisfaction predicted higher frequency of faking orgasm (β = -0.15; P = .008). Furthermore, while each variable itself was related to a number of motives for faking orgasm, the only motive assessed in our study that mediated the relationship between the 2 variables was insecurity about being perceived as abnormal or dysfunctional (indirect effect: β = -0.06; P = .008).

Clinical Translation

Insecurity related to being perceived as abnormal or deficient, along with sexual communication, should be addressed in women with a history of faking orgasm but who want to cease doing so.

Strengths and Limitations

The sample was relatively large and the online survey adhered to best practices. Nevertheless, bias may result in sample characteristics when recruitment is achieved primarily through social media. In addition, the cross-sectional sample prevented causal determination and represented Western-based values.

Conclusions

The associations between orgasmic difficulty and faking orgasm, and between relationship satisfaction and faking orgasm, are both direct and indirect (mediated). The primary motive for mediating the indirect association between the predictor variables and the frequency of faking orgasm was the insecurity about being perceived as deficient or abnormal.
Loneliness Versus Distress: A Comparison of Emotion Regulation Profiles
Authors: Tan Alyssa J. , Mancini Vincent , Gross James J. , Goldenberg Amit , Badcock Johanna C. , Lim Michelle H. , Becerra Rodrigo , Jackson Ben , Preece David A.
Published: September 2022

Loneliness, a negative emotion stemming from the perception of unmet social needs, is a major public health concern. Current interventions often target social domains but produce small effects and are not as effective as established emotion regulation (ER)-based interventions for general psychological distress (i.e., depression/anxiety). Given that loneliness and distress are types of negative affect, we aimed to compare them within an ER framework by examining the amount of variance ER strategies accounted for in loneliness versus distress, and comparing the ER strategy profiles characterising them. Participants (N = 582, Mage = 22.31, 77.66% female) completed self-report measures of loneliness, distress, and use of 12 cognitive (e.g., cognitive reappraisal) or behavioural (e.g., expressive suppression) ER strategies. Regression analyses revealed that ER explained comparable variance in these constructs. Latent profile analysis identified seven profiles differing in ER patterns, with no distinct loneliness or distress profile identified. Rather, similar patterns of ER characterised these two constructs, involving the greater use of generally maladaptive strategies and the lesser use of generally adaptive strategies. However, loneliness was additionally characterised by less use of strategies involving social connection/expression. Overall, our study supports the utility of ER for understanding loneliness. Established ER-based frameworks/interventions for distress may have transdiagnostic utility in targeting loneliness.
Modelling self-diagnosed burnout as a categorical syndrome
Authors: Tavella Gabriela , Spoelma Michael J. , Hadzi-Pavlovic Dusan , Bayes Adam , Jebejian Artin , Manicavasagar Vijaya , Walker Peter , Parker Gordon
Published: September 2022

Objective:

There is currently little consensus as to how burnout is best defined and measured, and whether the syndrome should be afforded clinical status. The latter issue would be advanced by determining whether burnout is a singular dimensional construct varying only by severity (and with some level of severity perhaps indicating clinical status), or whether a categorical model is superior, presumably reflecting differing ‘sub-clinical’ versus ‘clinical’ or ‘burning out’ vs ‘burnt out’ sub-groups. This study sought to determine whether self-diagnosed burnout was best modelled dimensionally or categorically.

Methods:

We recently developed a new measure of burnout which includes symptoms of exhaustion, cognitive impairment, social withdrawal, insularity, and other psychological symptoms. Mixture modelling was utilised to determine if scores from 622 participants on the measure were best modelled dimensionally or categorically.

Results:

A categorical model was supported, with the suggestion of a sub-syndromal class and, after excluding such putative members of that class, two other classes. Analyses indicated that the latter bimodal pattern was not likely related to current working status or differences in depression symptomatology between participants, but reflected subsets of participants with and without a previous diagnosis of a mental health condition.

Conclusion:

Findings indicated that sub-categories of self-identified burnout experienced by the lay population may exist. A previous diagnosis of a mental illness from a mental health professional, and therefore potentially a psychological vulnerability factor, was the most likely determinant of the bimodal data, a finding which has theoretical implications relating to how best to model burnout.
The control of vibration in helicopters
Authors: Balmford D. E. H.
Published: September 2022

The problems involving vibration which affect helicopters can be divided into two major categories:

(a)Forced vibration effects

(b)Aeroelastic and aeromechanical instabilities.

Forced vibration effects are subdivided into two categories.

(i)Effects due primarily to aerodynamic forcing; and

(ii)Effects due primarily to mechanical forcing.

Forced vibration effects have important repercussions in the area of:

(i)Crew comfort and efficiency

(ii)Fatigue strength of dynamic components and the airframe

(iii)Reliability of electronic equipment.

The most important forcing effect is aerodynamic in origin, and this will be considered first.
Caprylate/chromatography process to produce highly purified tetanus immune globulin from human plasma
Authors: Srivastava Jyoti , Talton Chad , Vandeberg Pete , Woznichak Michelle , Merritt W. Keither , Jose Marta
Published: September 2022

While tetanus toxoid vaccination has reduced the incidence of tetanus in the developed world, this disease remains a substantial health problem in developing nations. Tetanus immune globulin (TIG) is used along with vaccination for prevention of infection after major or contaminated wounds if vaccination status cannot be verified or for active tetanus infection. These studies describe the characterisation of a TIG produced by a caprylate/chromatography process. The TIG potency and presence of plasma protein impurities were analysed at early/late steps in the manufacturing process by chromatography, immunoassay, coagulation and potency tests. The caprylate/chromatography process has been previously shown to effectively eliminate or inactivate potentially transmissible agents from plasma-derived products. In this study, the caprylate/chromatography process was shown to effectively concentrate TIG activity and efficiently remove pro-coagulation factors, naturally present in plasma. This TIG drug product builds on the long-term evidence of the safety and efficacy of TIG by providing a product with higher purity and low pro-coagulant protein impurities.
Spin-Dependent Nonlinear Contrast Transfer in Transmission Electron Microscopy
Authors: Lentzen Markus
Published: September 2022

In this study, the spin-dependent nonlinear contrast transfer in transmission electron microscopy is derived from the eikonal expansion of the Dirac equation. The transmission cross-coefficient of the standard imaging theory is amended by a spin-dependent factor, whose effect is investigated for single scattering in the object by an electrical field under polarized and unpolarized illumination, and it is illustrated with numerical results and plots for a kinetic energy of 80 keV. The resulting image displacement and image convolution increase with decreasing kinetic energy but are always smaller than a wavelength. General features of the cross-coefficient are discussed to identify favorable conditions for the measurement of the small spin effects, possibly in an unmodified instrument.
Qualitätsstandards in der Alterspsychiatrie
Authors: Klöppel Stefan , von Gunten Armin , Georgescu Dan
Published: September 2022

Zusammenfassung. Qualitätsstandards und -regulierungen gewinnen zunehmend an Bedeutung und werden im Rahmen der Zulassung zur Behandlung, zur Abrechnung und über finanzielle Anreize gefördert. Dabei wird in den genannten Regelwerken der Fokus in jeweils unterschiedlichem Umfang auf Struktur-, Prozess- oder Ergebniskriterien gerichtet. Im Namen der Schweizerischen Gesellschaft für Alterspsychiatrie und -psychotherapie (SGAP) fassen wir in diesem Dokument die Qualitätselemente zusammen und gruppieren die sich daraus ableitenden Vorgaben anhand des Settings (ambulant, intermediär, stationär) und Kriterien der Strukturqualität (Personalschlüssel, Infrastruktur). Es besteht eine sehr umfangreiche Anforderungsmatrix, deren Umsetzung nicht zuletzt aufgrund des Fachkräftemangels und beschränkter finanzieller Ressourcen von Institutionen und Arztpraxen erhebliche Anstrengungen erfordert. Die in der Anforderungsmatrix hinterlegten Kriterien sollten weiterentwickelt und in einer «kompetenzbasierten Weiterbildung Alterspsychiatrie» verankert werden.
On the Incorporation of Nonlinear Resonant Wave‐Particle Interactions Into Radiation Belt Models
Authors: Artemyev A. V. , Mourenas D. , Zhang X.‐J. , Vainchtein D.
Published: September 2022

Wave‐particle resonant interaction is a key process controlling energetic electron flux dynamics in the Earth's radiation belts. All existing radiation belt codes are Fokker‐Planck models relying on the quasi‐linear diffusion theory to describe the impact of wave‐particle interactions. However, in the outer radiation belt, spacecraft often detect waves sufficiently intense to interact resonantly with electrons in the nonlinear regime. In this study, we propose an approach for estimating and including the contribution of such nonlinear resonant interactions into diffusion‐based radiation belt models. We consider electron resonances with whistler‐mode wave‐packets responsible for injected plasma sheet (∼100 keV) electron acceleration to relativistic energies and/or for their precipitation into the atmosphere. Using statistics of chorus wave‐packet amplitudes and sizes (number of wave periods within one packet), we provide a rescaling factor for quasi‐linear diffusion rates, that accounts for the contribution of nonlinear interactions in long‐term electron flux dynamics. Such nonlinear effects may speed up 0.1–1 MeV electron diffusive acceleration by a factor of ×1.5–2 during disturbed periods. We discuss further applications of the proposed approach and the importance of nonlinear resonant interactions for long‐term radiation belt dynamics.
Early Anthropogenic Impacts on the Indian Summer Monsoon Induced by Land‐Use and Land‐Cover Changes
Authors: Lin Ke , Shen Chuan‐Chou , Duan Wuhui , Tan Liangcheng , Kong Xinggong , Lee Shih‐Yu , Chen Yue‐Gau , Wang Xianfeng
Published: September 2022

The impacts of anthropogenic forcing on Indian summer monsoon (ISM) rainfall are obscure, partly due to limited availability of highly resolved hydroclimate proxy records as well as the highly regionalized nature of precipitation. Here, we report an annually‐resolved speleothem oxygen isotope record from Xianren Cave, southwestern China, which represents rainfall change over the broad ISM region. We find that the region has endured at least six decadal‐scale weak monsoon events in the past three hundred years. One of them, lasting from the early to mid 19th century, shares the similar gradual, persistent trend as the most recent decline in ISM rainfall and both have a magnitude substantially larger than the others dominated by natural variability. This early weak monsoon event occurred during a historical time of intensive deforestation in the region. We conclude that the ISM trend could have been altered by the changes in land‐use and land‐cover since the early 19th century.
ML Prediction of Global Ionospheric TEC Maps
Authors: Liu Lei , Morton Y. Jade , Liu Yunxiang
Published: September 2022

This paper applies the convolutional long short‐term memory (convLSTM)‐based machine learning models to forecast global ionospheric total electron content (TEC) maps with up to 24 hr of lead time at a 1‐hr interval. Four convLSTM‐based models were investigated, and the one that implements the L1 loss function and the residual prediction strategy demonstrates the best performance. The convLSTM models are trained and evaluated using Center for Orbit Determination in Europe (CODE) global TEC maps over a period of nearly seven years from 19 October 2014 to 21 July 2021. Results show that the best convLSTM model outperforms the 1‐day predicted global TEC products released by CODE analysis center (c1pg) and persistence models under various levels of solar and geomagnetic activities, except for a lead time beyond 8 hr during the storm time where the c1pg has slightly better performance. The convLSTM forecasting performance degrades as the lead time increases.
Sustained TNF signaling is required for the synaptic and anxiety-like behavioral response to acute stress
Authors: Kemp Gina M. , Altimimi Haider F. , Nho Yoonmi , Heir Renu , Klyczek Adam , Stellwagen David
Published: September 2022

Acute stress triggers plasticity of forebrain synapses as well as behavioral changes. Here we reveal that Tumor Necrosis Factor α (TNF) is a required downstream mediator of the stress response in mice, necessary for stress-induced synaptic potentiation in the ventral hippocampus and for an increase in anxiety-like behaviour. Acute stress is sufficient to activate microglia, triggering the long-term release of TNF. Critically, on-going TNF signaling specifically in the ventral hippocampus is necessary to sustain both the stress-induced synaptic and behavioral changes, as these could be reversed hours after induction by antagonizing TNF signaling. This demonstrates that TNF maintains the synaptic and behavioral stress response in vivo, making TNF a potential novel therapeutic target for stress disorders.
Microbial invasion of a toxic medium is facilitated by a resident community but inhibited as the community co-evolves
Authors: Piccardi Philippe , Alberti Géraldine , Alexander Jake M , Mitri Sara
Published: September 2022

Predicting whether microbial invaders will colonize an environment is critical for managing natural and engineered ecosystems, and controlling infectious disease. Invaders often face competition by resident microbes. But how invasions play out in communities dominated by facilitative interactions is less clear. We previously showed that growth medium toxicity can promote facilitation between four bacterial species, as species that cannot grow alone rely on others to survive. Following the same logic, here we allowed other bacterial species to invade the four-species community and found that invaders could more easily colonize a toxic medium when the community was present. In a more benign environment instead, invasive species that could survive alone colonized more successfully when the residents were absent. Next, we asked whether early colonists could exclude future ones through a priority effect, by inoculating the invaders into the resident community only after its members had co-evolved for 44 weeks. Compared to the ancestral community, the co-evolved resident community was more competitive toward invaders and less affected by them. Our experiments show how communities may assemble by facilitating one another in harsh, sterile environments, but that arriving after community members have co-evolved can limit invasion success.
Structure of the membrane-bound formate hydrogenlyase complex from Escherichia coli
Authors: Steinhilper Ralf , Höff Gabriele , Heider Johann , Murphy Bonnie J.
Published: September 2022

The prototypical hydrogen-producing enzyme, the membrane-bound formate hydrogenlyase (FHL) complex from Escherichia coli, links formate oxidation at a molybdopterin-containing formate dehydrogenase to proton reduction at a [NiFe] hydrogenase. It is of intense interest due to its ability to efficiently produce H2 during fermentation, its reversibility, allowing H2-dependent CO2 reduction, and its evolutionary link to respiratory complex I. FHL has been studied for over a century, but its atomic structure remains unknown. Here we report cryo-EM structures of FHL in its aerobically and anaerobically isolated forms at resolutions reaching 2.6 Å. This includes well-resolved density for conserved loops linking the soluble and membrane arms believed to be essential in coupling enzymatic turnover to ion translocation across the membrane in the complex I superfamily. We evaluate possible structural determinants of the bias toward hydrogen production over its oxidation and describe an unpredicted metal-binding site near the interface of FdhF and HycF subunits that may play a role in redox-dependent regulation of FdhF interaction with the complex.
Understanding Braess’ Paradox in power grids
Authors: Schäfer Benjamin , Pesch Thiemo , Manik Debsankha , Gollenstede Julian , Lin Guosong , Beck Hans-Peter , Witthaut Dirk , Timme Marc
Published: September 2022

The ongoing energy transition requires power grid extensions to connect renewable generators to consumers and to transfer power among distant areas. The process of grid extension requires a large investment of resources and is supposed to make grid operation more robust. Yet, counter-intuitively, increasing the capacity of existing lines or adding new lines may also reduce the overall system performance and even promote blackouts due to Braess’ paradox. Braess’ paradox was theoretically modeled but not yet proven in realistically scaled power grids. Here, we present an experimental setup demonstrating Braess’ paradox in an AC power grid and show how it constrains ongoing large-scale grid extension projects. We present a topological theory that reveals the key mechanism and predicts Braessian grid extensions from the network structure. These results offer a theoretical method to understand and practical guidelines in support of preventing unsuitable infrastructures and the systemic planning of grid extensions.
Mesoscopic sliding ferroelectricity enabled photovoltaic random access memory for material-level artificial vision system
Authors: Sun Yan , Xu Shuting , Xu Zheqi , Tian Jiamin , Bai Mengmeng , Qi Zhiying , Niu Yue , Aung Hein Htet , Xiong Xiaolu , Han Junfeng , Lu Cuicui , Yin Jianbo , Wang Sheng , Chen Qing , Tenne Reshef , Zak Alla , Guo Yao
Published: September 2022

Intelligent materials with adaptive response to external stimulation lay foundation to integrate functional systems at the material level. Here, with experimental observation and numerical simulation, we report a delicate nano-electro-mechanical-opto-system naturally embedded in individual multiwall tungsten disulfide nanotubes, which generates a distinct form of in-plane van der Waals sliding ferroelectricity from the unique combination of superlubricity and piezoelectricity. The sliding ferroelectricity enables programmable photovoltaic effect using the multiwall tungsten disulfide nanotube as photovoltaic random-access memory. A complete “four-in-one” artificial vision system that synchronously achieves full functions of detecting, processing, memorizing, and powering is integrated into the nanotube devices. Both labeled supervised learning and unlabeled reinforcement learning algorithms are executable in the artificial vision system to achieve self-driven image recognition. This work provides a distinct strategy to create ferroelectricity in van der Waals materials, and demonstrates how intelligent materials can push electronic system integration at the material level.
Energy comparison of sequential and integrated CO2 capture and electrochemical conversion
Authors: Li Mengran , Irtem Erdem , Iglesias van Montfort Hugo-Pieter , Abdinejad Maryam , Burdyny Thomas
Published: September 2022

Integrating carbon dioxide (CO2) electrolysis with CO2 capture provides exciting new opportunities for energy reductions by simultaneously removing the energy-demanding regeneration step in CO2 capture and avoiding critical issues faced by CO2 gas-fed electrolysers. However, understanding the potential energy advantages of an integrated process is not straightforward due to the interconnected processes which require knowledge of both capture and electrochemical conversion processes. Here, we identify the upper limits of the integrated process from an energy perspective by comparing the working principles and performance of integrated and sequential approaches. Our high-level energy analyses unveil that an integrated electrolyser must show similar performance to the gas-fed electrolyser to ensure an energy benefit of up to 44% versus the sequential route. However, such energy benefits diminish if future gas-fed electrolysers resolve the CO2 utilisation issue and if an integrated electrolyser shows lower conversion efficiencies than the gas-fed system.
Exploiting degeneracy in belief propagation decoding of quantum codes
Authors: Kuo Kao-Yueh , Lai Ching-Yi
Published: September 2022

Quantum information needs to be protected by quantum error-correcting codes due to imperfect physical devices and operations. One would like to have an efficient and high-performance decoding procedure for the class of quantum stabilizer codes. A potential candidate is Gallager’s sum-product algorithm, also known as Pearl’s belief propagation (BP), but its performance suffers from the many short cycles inherent in a quantum stabilizer code, especially highly-degenerate codes. A general impression exists that BP is not effective for topological codes. In this paper, we propose a decoding algorithm for quantum codes based on quaternary BP with additional memory effects (called MBP). This MBP is like a recursive neural network with inhibitions between neurons (edges with negative weights), which enhance the perception capability of a network. Moreover, MBP exploits the degeneracy of a quantum code so that the most probable error or its degenerate errors can be found with high probability. The decoding performance is significantly improved over the conventional BP for various quantum codes, including quantum bicycle, hypergraph-product, surface and toric codes. For MBP on the surface and toric codes over depolarizing errors, we observe error thresholds of 16% and 17.5%, respectively.
Delayed fluorescence from inverted singlet and triplet excited states
Authors: Aizawa Naoya , Pu Yong-Jin , Harabuchi Yu , Nihonyanagi Atsuko , Ibuka Ryotaro , Inuzuka Hiroyuki , Dhara Barun , Koyama Yuki , Nakayama Ken-ichi , Maeda Satoshi , Araoka Fumito , Miyajima Daigo
Published: September 2022

Hund’s multiplicity rule states that a higher spin state has a lower energy for a given electronic configuration1. Rephrasing this rule for molecular excited states predicts a positive energy gap between spin-singlet and spin-triplet excited states, as has been consistent with numerous experimental observations over almost a century. Here we report a fluorescent molecule that disobeys Hund’s rule and has a negative singlet–triplet energy gap of −11 ± 2 meV. The energy inversion of the singlet and triplet excited states results in delayed fluorescence with short time constants of 0.2 μs, which anomalously decrease with decreasing temperature owing to the emissive singlet character of the lowest-energy excited state. Organic light-emitting diodes (OLEDs) using this molecule exhibited a fast transient electroluminescence decay with a peak external quantum efficiency of 17%, demonstrating its potential implications for optoelectronic devices, including displays, lighting and lasers.
TOPSIS aided ensemble of CNN models for screening COVID-19 in chest X-ray images
Authors: Pramanik Rishav , Dey Subhrajit , Malakar Samir , Mirjalili Seyedali , Sarkar Ram
Published: September 2022

The novel coronavirus (COVID-19), has undoubtedly imprinted our lives with its deadly impact. Early testing with isolation of the individual is the best possible way to curb the spread of this deadly virus. Computer aided diagnosis (CAD) provides an alternative and cheap option for screening of the said virus. In this paper, we propose a convolution neural network (CNN)-based CAD method for COVID-19 and pneumonia detection from chest X-ray images. We consider three input types for three identical base classifiers. To capture maximum possible complementary features, we consider the original RGB image, Red channel image and the original image stacked with Robert's edge information. After that we develop an ensemble strategy based on the technique for order preference by similarity to an ideal solution (TOPSIS) to aggregate the outcomes of base classifiers. The overall framework, called TOPCONet, is very light in comparison with standard CNN models in terms of the number of trainable parameters required. TOPCONet achieves state-of-the-art results when evaluated on the three publicly available datasets: (1) IEEE COVID-19 dataset + Kaggle Pneumonia Dataset, (2) Kaggle Radiography dataset and (3) COVIDx.
Overcoming the strength–formability trade-off in high strength steels via cryogenic treatment
Authors: Park Gyeongbae , Zargaran A. , Oh J. K. , Trang T. T. T. , Kim N. J.
Published: September 2022

High strength steels are becoming more important than ever before for automotive applications to reduce the weight of automobiles and to ensure the safety of passengers. Since increased strength usually results in degraded formability, however, cold forming of high strength steels into final shapes remains a challenge to both automotive manufacturers and suppliers. Here we report novel alloy and processing design concepts that can impart high strength to cold-formable steels, which deviates from the traditional approach of improving the formability of high strength steels. Such designed steel subjected to a designed processing route shows an excellent combination of formability and strength as well as crashworthiness, which is crucial for the safety of passengers in the automobiles. The alloy and processing design concepts used in the present study are based on the utilization of thermally induced austenite to martensite transformation, which imparts high strength to cold-formable austenite by cryogenic treatment.