bluuebunny/crossref_metadata_2025 huggingface dataset:
Ethics, Mindfulness, and Consciousness: A Study of Their Relation in Early Buddhism
Authors: Shulman Eviatar
Published: October 2024

Scholarly discussions of mindfulness normally treat the term as reflecting a specific, independent, psychological function. Here, mindfulness is placed  within a broader understanding of the Buddhist cultivation of consciousness, with special attention to the ethical aspects of mindfulness. Focusing on sources from early Buddhism, the article demonstrates how ethics was thought to have a positive, indeed a necessary, effect on a successful practice of mindfulness. The article moves beyond the Sati-paṭṭhāna-sutta (“The Foundations of Mindfulness”), which has been emphasized in scholarship, to related texts in the Middle Length Discourses (Majjhima-Nikāya) and beyond them to other Pāli sources. Here, we learn that “You should cultivate the four applications of mindfulness based on ethics, established in ethics.” While the emphasis on ethics in these sources reminds us of the conceptual dimensions of mindfulness, it also allows scholars to see both ethics and mindfulness as partaking in the broader attempt to enrich consciousness and make it healthier, softer, and more lucid. Buddhist practice works to change the structures of subjectivity and make them more conducive to liberation, in whatever way it may be defined. Thus, the Buddhist contemplative tradition can be seen to participate in an effort to change the quality of consciousness, rather than being a mere attempt to reach an annihilation of “suffering.” These considerations allow us to see mindfulness as a form of ethical activity in itself.
Pedicled Anterolateral Thigh Flap (ALT) for Vulva Reconstruction: Journey to a New Horizon
Authors: Begum Dimpy , Barmon Debabrata , Baruah Upasana , Darak Shruti , Aparajita R. , Kumar Mahendra , Bassetty Karthik Chandra
Published: October 2024

Surgery for vulval malignancies necessitates extensive resection necessitating the use of musculocutaneous grafts. We present one such case where the patient needed both a V–Y plasty and an anterolateral thigh flap to ensure a tension-free repair. She underwent a partial deep vulvectomy followed by V–Y plasty and ALT flap. The procedure has been described in detail along with intraoperative photographs. She recovered uneventfully and is receiving post-operative adjuvant radiotherapy. We would like to highlight this “additional skill” of plastic surgery which will empower surgeons to undertake radical surgeries to ensure the best outcomes for patients.
Comparison of laparoscopic hepatectomy and radiofrequency ablation for small hepatocellular carcinoma patients: a SEER population-based propensity score matching study
Authors: Wang Xi , Chai Xinqun , Tang Ruiya , Xu Yunjie , Chen Qinjunjie
Published: October 2024

This study was designed to compare the efficacy of laparoscopic hepatectomy (LH) and radiofrequency ablation (RFA) in terms of their therapeutic effect on small hepatocellular carcinoma (SHCC). The SEER database was employed to integrate SHCC patients who had received treatment with either LH (n = 1132) or RFA (n = 797). The LH group (n = 623) and the RFA group (n = 623) were matched with 1:1 propensity score matching (PSM) in order to reduce the possibility of selection bias. The Kaplan–Meier method and Cox proportional hazards regression method were employed to ascertain the prognostic factors associated with overall survival (OS) and disease-specific survival (DSS). Both before and after PSM, the 1, 3 and 5-years OS and DSS were significantly higher in the LH groups compared to the RFA group. Besides, for SHCC with tumor size ≤ 2cm (n = 418), even P values not reaching statistical significance, the survival curves were compatible with a superiority of LH over RFA for OS and DSS in overall (P = 0.054 and P = 0.077), primary SHCC (P = 0.110 and P = 0.058) and recurrent SHCC (P = 0.068 and P = 1.000) cohorts. In contrast, for SHCC with tumor size between 2 and 3 cm (n = 828), LH group always had a better OS and DSS in the all cohorts (all P < 0.05). In addition, higher AFP level, poor differentiation grade, recurrent tumor and treatment type were independent prognostic factors for OS, while poor differentiation grade, larger tumor size and treatment type were the independent prognostic factors for DSS (all P < 0.05). LH was associated with better OS and DSS than RFA in SHCC patients. Even in tumor size ≤ 2 cm, LH still should be the first choice as its long-term survival benefits.
Agile Backward Design: A Framework for planning higher education curriculum
Authors: Dazeley Richard , Goriss-Hunter Anitra , Meredith Grant , Sellings Peter , Firmin Sally , Burke Jenene , Panther Barbie
Published: October 2024

In the last two decades there has been an increase in research and discussion regarding curriculum in Higher Education (HE). The literature in this field tends to focus on curriculum change at either the whole institution or individual program or unit level. Formal writing on HE curriculum also does not offer a framework that openly draws upon context, learner needs, pedagogical approaches, and industry requirements to formulate a collaborative model of curricular development. To fill these gaps in HE curriculum discussion and literature the aim of this study was to develop a cross-disciplinary model applicable to both unit (academic module that makes up a program) and program (degree) levels of curriculum development by enabling academics to generate and structure engaging learning opportunities for students. The research team developed this model by drawing on elements of Agile mindset and Backward Design. We call it Agile Backward Design (ABD). This paper reports on this new approach to curricular design. A critical reflective inquiry approach was used to discuss the development of the model. To report the transformation that was made at the program and unit level a case study was employed. In ABD, the researchers have constructed a dynamic and responsive framework that has been foundational in the design and development of innovative curriculum and pedagogy at the unit and program level of undergraduate degrees in the IT discipline area.
Regenerative Medicine Approaches for Skin Wound Healing: from Allografts to Engineered Skin Substitutes
Authors: Mahajan Naresh , Soker Shay , Murphy Sean Vincent
Published: October 2024

Purpose of the Review

Recent advancements in tissue engineering and regenerative medicine have paved the way for innovative solutions in skin regeneration, particularly for extensive burns and full-thickness wounds where traditional approaches are limited. The purpose of the review is to explore the integration of bioactive materials, stem cell therapies, and tissue-engineered skin substitutes and their role in revolutionizing wound healing and skin transplantation.

Recent Findings

Studies leveraging natural and synthetic biomaterials as scaffolds, alongside the regenerative capabilities of mesenchymal stem cells (MSCs) and other cellular therapies, underscore the potential to enhance tissue repair, minimize scarring, and improve overall clinical outcomes. The development of multifunctional biomaterials and the advent of cutting-edge techniques such as 3D bioprinting and nanomedicine further propel the field, offering personalized and effective solutions. As these technologies evolve, they hold promise for more efficient, patient-specific skin grafting, reducing the need for systemic immunosuppression and enhancing graft survival.

The critical advancements in biomaterials, stem cell therapies, and tissue engineering, outline a course toward more effective and personalized skin regeneration therapies.
The Influence of the COVID-19 Pandemic on Small Business Support for Youth Physical Activity Opportunities in Urban, Low-Income, Predominantly Black Neighborhoods
Authors: Suminski Richard R. , Kelly Kristin , Firkin Cora J.
Published: October 2024

Background

A relatively low percentage of Black youth meet physical activity (PA) guidelines. An important resource for helping Black youth be physically active is the availability of quality youth physical activity opportunities (YPAO) which manifest, in part, due to support from small businesses. The coronavirus disease 2019 (COVID-19) pandemic was a devastating negative societal event that disproportionately burdened the Black community. How the pandemic influenced the relationship between small businesses and YPAOs in this community is vital for understanding the promotion of PA in this high-risk population going forward.

Purpose

To describe small business support for YPAO before and after 2 years of exposure to the COVID-19 pandemic.

Methods

In-person interviews were conducted June through August 2019 (pre-COVID) and 2021 (post-COVID) with owners and managers at small businesses in 20 urban, low-income, predominantly Black neighborhoods.

Results

The number of YPAOs supported was significantly greater pre-COVID (n = 104) versus post-COVID (n = 52) (t = 4.6; p < .001). From pre-COVID to post-COVID, the types of YPAOs supported by businesses shifted from a diverse mix to mostly (96%) outdoor, community sports teams. Businesses were more likely to provide goods and services (p = .02) for YPAOs pre-COVID than post-COVID. The major reason for not supporting YPAOs pre-COVID was “not being asked for support” then “not being able to locate YPAOs to support” post-COVID.

Conclusion

Exposure to COVID-19 is associated with significant changes in how small businesses support YPAOs. The results are useful for informing strategies and public policies aimed at promoting YPAO support through prominent negative societal events.
Pearls of Wisdom from Teaching Rounds: Reconceptualizing “See One, Do One” as Social Learning
Authors: Newman Jessica R. , Hughes Dorothy
Published: October 2024

Background

Experiential education is paramount to clinical instruction in medicine. During teaching rounds, faculty can assess medical knowledge and clinical reasoning while modeling evidence-based patient care and effective communication. This study aimed to describe observed traits common across faculty who contribute to favorable learning environments.

Design

Students completed an Internal Medicine (IM) Student Chief elective at a midwestern United States Academic Tertiary Care Center in which M4s aided Clerkship leadership in near-peer teaching and communicating with students. Chiefs participated in rounds for experiential learning in clinical teaching. For this qualitative, descriptive study, M4s were asked to provide at least three “pearls of wisdom,” on observations about teaching and learning in reflective essays during two consecutive academic years. Twenty-nine M4s participated in the elective and submitted 238 pearls. The research team undertook document review and qualitatively analyzed content of Chiefs’ reflective essays. Detailed codes were organized into primary and secondary themes by each author, and then re-evaluated until they reached consensus. Through thematic analysis, we identified faculty traits students found conducive to learning.

Results

Three primary themes emerged: Attributes, Autonomy, and Achieving Engagement.

Conclusion

Experiential educational encounters are transformative to developing new physicians. Chiefs highlighted positive aspects of teaching rounds described previously including providing clear expectations, promoting goal setting, engagement, and instilling confidence. They also valued humor, recognizing cognitive overload, displaying humility, listening skills, and mentorship. While one attending cannot replicate all described effective techniques simultaneously, faculty development that promotes refining these approaches may improve the clinical learning environment for all learners.
Organizations in the Space of Reasons
Authors: Bernacchio Caleb
Published: October 2024

Bounded rationality presents a challenge to the notion that virtue is a capacity for knowledge, suggesting that judgments concerning the salience of specific facts are, in some cases, an indication of one’s incapacity to appreciate the full range of normatively salient facts. This problem can be mitigated by linking an account of the virtues with a theory of organizations. From this perspective, virtue is inherently shaped by the norms structuring one’s role(s) and is linked to the complementary set of roles, that is, the organization, in which one is participating through the virtues of loyalty and obedience. Within this perspective, human cognitive limitations are made to be strengths, allowing one to focus on a narrow set of reasons for action linked with one’s role to better achieve salient aims as a member of the organization than one could as an isolated individual.
Chemical weapons investigation mechanisms in Syria: standards of proof and methods of work
Authors: Albalawi Almuntaser , Burck Kristoffer
Published: October 2024

Several ad-hoc mechanisms were established for fact-finding and attributing responsibility for chemical weapons allegations in Syria. With distinctive mandates, these mechanisms adopted different working methods and applied varying standards of proof to achieve their objectives. This paper presents an analysis of the four main investigation mechanisms on alleged chemical weapons use in Syria, drawing on over forty relevant official reports, documents, and memos. The analysis entails juxtaposing the main attributes of these mechanisms: mandate, founding body, standards of proof, and adopted scientific and technical working methods. By doing so, the paper demonstrates the interdependency between the mechanisms and explains correlations between their constituting attributes. While attribution mechanisms apply a wider range of technologies and work methods, they did not consistently exhibit a higher standard of proof. This challenges the assumption that the mandate and technology use determine the applied standard of proof. Rather, the paper finds that the founding bodies have the most significant influence on standards of proof. United Nations-mandated mechanisms, for instance, employ a higher standard than those founded by the Organization for the Prohibition of Chemical Weapons (OPCW). The paper discusses contributing factors to this finding including, political support, anticipated and granted levels of cooperation and access, and reporting of findings.
Horizons of Possibility—Young People’s Encounters with Nature and Their Qualities in Social Programs
Authors: Sørensen Niels Ulrik , Nielsen Anne Mette W.
Published: October 2024

This article presents an analysis of young people’s encounters with nature within a context of social programs. In the intersection between nature and social initiatives, nature is often defined as something that contains a range of inherent properties that can have a positive impact on various aspects of young people’s lives—such as their well-being, development and learning. However, there is a lack of analyses that focus on the manifold, diverse and divergent exchanges and liaisons that young people’s encounters with nature can give rise to. Based on an approach, where humans and nature are considered so intertwined that one cannot be meaningfully understood without the other (Haraway 2021, Latour 2005), the aim of the article is to shed light on the many different types of entanglements and interconnections that unfold in young people’s encounters with nature, as well as on the processes of becoming they are associated with. Drawing on a qualitative study, the article develops a typology of six significant types of entanglements and interconnections between young people and nature. It is a characteristic of these entanglements and interconnections that they unfold depending on how the encounters between young people and nature are framed by the social programs. They are thus not defined by already known outcomes, but can be understood as ‘figurations’ (Braidotti 1994), that contain both a lived here and now and an ‘imagined elsewhere’ (Haraway 1991). The article shows how this perspective confronts deficit discourses, where young people in social programs are seen as either lacking resources and agency or whose resources and agency are going in the wrong direction, as well as those contemporary discourses that position and problematize the overall present youth generation as fragile, hypersensitive and disoriented.
A more accurate Co-Content function calculation, using alternative integration methods, for Current–Voltage curves measured in the zero volt to open-circuit voltage range
Authors: Rangel-Kuoppa Victor-Tapio
Published: October 2024

In this article, the application of the Newton–Cotes quadrature formula, the 3/8 rule, the Boole’s rule, and order 5 and 6 integration techniques, are explored to more accurately calculate the Co-Content function, of Current–Voltage (IV) measurements done between 0 V and the open circuit voltage, which include a percentage noise of the short circuit current. Their impact on the extraction of the five photovoltaic devices’ parameters (within the one-diode model) is investigated and reported. The shunt resistance, series resistance, ideality factor, and photocurrent can be obtained with less than 10% error, using these integration techniques and 101 measured points per volt, when the percentage noise is 0.05% or less, of the short circuit current. It is not possible to obtain the saturation current with less than 10% error. These integration techniques are implemented in photovoltaic devices, such as solar cells and single-crystalline silicon, CdTe, CIGS, and heterojunction with intrinsic thin-layer solar panels IV curves, to extract the five solar cell parameters.
Justification and update
Authors: Peijnenburg Jeanne , Atkinson David
Published: October 2024

In this commentary on Jun Otsuka’s first-rate book, we focus on the difference between justification and update.
Aerospike nozzle contour design using Angelino’s method and CFD validation
Authors: Silva João C. , Brójo Francisco
Published: October 2024

The goal of the present study is to implement an algorithm capable of designing linear aerospike contours and develop a numerical investigation of the altitude adaptive behavior and performance of high enthalpy flow expanded with such contoured nozzle. The contour was designed using Angelino,s rapid method, targeting an exit Mach number of 4.16. An inviscid model and viscous model (employing the realizable k-$$\epsilon$$
ϵ
for turbulence) were considered and the results compared, showing that turbulent effects must be taken into account to properly simulate important flowfield aspects such as static pressure, static temperature, entropy and viscous losses. The specific impulse is used as the performance criterion and it was observed that it increased with altitude, with only a 2$$\%$$
%
decrease from an ideal bell nozzle for an underexpanding operation, situation where a nearly axial exhaust plume is obtained. Conversely, when turbulent effects are taken into account, overexpanded conditions have the lowest specific impulse, being lower than a quasi-1D analysis and the inviscid case. The findings summit the advantages of the aerospike nozzle over conventional nozzles. Conventional nozzles not only typically struggle in underexpansion scenarios, but also have high side-loads in overexpansion, due to flow detaching from the nozzle’s wall. A further conclusion is that the realizable k-$$\epsilon$$
ϵ
turbulent model proved a reliable and fast tool to evaluate turbulent effects that characterize the aerospike flowfield.
Learning a generalizable re-identification model from unlabelled data with domain-agnostic expert
Authors: Liu Fangyi , Ye Mang , Du Bo
Published: October 2024

In response to real-world scenarios, the domain generalization (DG) problem has spurred considerable research in person re-identification (ReID). This challenge arises when the target domain, which is significantly different from the source domains, remains unknown. However, the performance of current DG ReID relies heavily on labor-intensive source domain annotations. Considering the potential of unlabeled data, we investigate unsupervised domain generalization (UDG) in ReID. Our goal is to create a model that can generalize from unlabeled source domains to semantically retrieve images in an unseen target domain. To address this, we propose a new approach that trains a domain-agnostic expert (DaE) for unsupervised domain-generalizable person ReID. This involves independently training multiple experts to account for label space inconsistencies between source domains. At the same time, the DaE captures domain-generalizable information for testing. Our experiments demonstrate the effectiveness of this method for learning generalizable features under the UDG setting. The results demonstrate the superiority of our method over state-of-the-art techniques. We will make our code and models available for public use.
Geochemical characterization and reserve estimation of the economic heavy minerals of Sonadia Island, Bangladesh
Authors: Hossain Md Sakaouth , Rahman Md. Shahriar , Taki Golam , Jahan Maftuha
Published: October 2024

The goal of the current study is to understand the elemental concentration, reserve assessment, mineralogical composition, and distribution of heavy minerals in the dune sands, foreshore, and backshore of Sonadia Island, Southeast Bangladesh. The study area yielded a number of drill hole composite sand samples that were used for density and magnetic separation of heavy minerals. These samples were then subjected to petrographic characterization, grain counting, mineralogical analyses using scanning electron microscopy-energy dispersive X-ray spectroscopy (SEM–EDX), x-ray diffraction (XRD), and bulk sand geochemistry using X-ray fluorescence (XRF). The results of heavy liquid separation show that the total heavy mineral (THM) enrichments in foreshore sand (about 4.86%), backshore sand (about 9.03%), and dune sand (about 22.28%) are significantly higher. After characterizing the sand samples from Sonadia Island based on the abundance of each mineral species, the average content values relative to total economic heavy minerals (TEHM) were determined to be 38.14% ilmenite, 5.74% magnetite, 51.52% garnet, 1.01% zircon, 3.57% rutile, and 0.01% monazite. An SEM–EDX examination reveals that the elemental concentration of ZrO2 in zircon is 66.60%, while the average TiO2 content in rutile is ~ 95%, whereas TiO2 is 45% and the total Fe2O3 is 45.70% in ilmenite. Major phases including amphibole (tremolite) 45.9%, muscovite 15.6%, quartz 12.6%, garnet (almandine) 10.9%, dolomite 7.9%, ilmenite 4.1%, and kaolinite 1.3% are also identified by the XRD pattern. There are an estimated 19,794 tons of garnet in the foreshore sand, 47,324 tons in the backshore sand, and 276,868 tons in the dune sand within the reserve, making it the most prevalent heavy mineral. Ilmenite is the second most common heavy mineral, with quantities detected in the foreshore (15,016 tons), backshore (30,487 tons), and dune sand (215,092 tons).
Edcraft: Gamified Handicrafts as an Inspiration for Teenagers to Practice Upcycling
Authors: Tan Xin Yee , Cheng Kin Meng , Chong Chin Wei , Koo Ah-Choo
Published: October 2024

This qualitative research study investigates the effectiveness of gamified handicrafts as an inspiration for teenagers to practice recycling and upcycling. The study utilises focus group interviews and thematic analysis to explore the perceptions and experiences of 15 teenagers who participated in an educational programme called Edcraft, which combines gamification and handicrafts to promote sustainable practices among youth. The findings reveal that Edcraft successfully motivates teenagers to engage in recycling and upcycling activities through its gamified approach, which includes challenges, rewards and social interaction. Themes such as ‘social connections are vital’, ‘convenience and rewards are significant motivators’, ‘gamified activities help attract and engage teens’ and ‘environmental knowledge is crucial to prolonging recycling’ emerged from the thematic analysis. The results also highlight the positive impact of Edcraft on teenagers’ attitudes towards the environment and their willingness to adopt sustainable behaviours beyond the programme. The implications of these findings for promoting environmental education and sustainability among teenagers are discussed, and recommendations for future research and practice are provided.
Normalizing and Mainstreaming the French Radical Right: Divergences in Leadership Communication during a Summer of Inland and Borderland Tensions
Authors: Lamour Christian
Published: October 2024

The radical right has become a central political force in most Western democracies. This process has been the result of the normalization and mainstreaming of its political leaders, discourses, and visions of society, notably involving the scapegoating of immigration and the use of the Great Replacement conspiracy theory. However, the normalization and mainstreaming of radical right actors competing for the leadership of their overall political family remain an under-researched topic. The scope of the current article is to explore this phenomenon by considering the case of France, which after the United States, is the largest Western state that could potentially be ruled by a radical right president with extensive executive powers. The analysis shows that actors competing for the leadership of the radical right in a given country can generate diverging strategies of normalization and mainstreaming to secure their political distinction. Immigration and the Great Replacement constitute, respectively, a topic and a conspiracy theory that are emphasized and/or downplayed by opportunistic stakeholders weaving a web of interactions to define their comparative legitimacy and supremacy in the public sphere.
Zinc and iron biofortification of crops grown in a vertical farm
Authors: Bucky A. , Pičmanová M. , Porley V. , Pont S. , Johnstone A. , Stewart D.
Published: October 2024

With the growing global population and climate change, achieving food security is a pressing challenge(1). Vertical farming has the potential to support local food production and security. In the UK population females and younger adults appear to be particularly vulnerable to micronutrient shortfalls from food sources alone. Levels of micronutrient intakes including zinc and iron are below the recommended daily intake(2). As a Total Controlled Environment Agriculture (TCEA) system, vertical farming employs hydroponics using a nutrient solution which offers opportunities to modulate nutrient uptake, and thus influence plant mineral and vitamin composition(3).

In this study we aimed to determine the suitability of different crop types for soilless agronomic biofortification with zinc and iron to achieve biofortified crops.

In this study, we investigated the effect of the addition of 20ppm (+20 mg L−1) of zinc (ZnSO4) or iron (Fe-EDTA) to the nutrient solution on the growth and nutritional components in pea microgreens, kale microgreens and kale baby leaf plants. The growth conditions were kept identical throughout the treatments with photoperiod 18 h d-1, temperature 20-22°C and relative humidity at 70-80%. Plant growth, mineral composition, glucosinolate content and protein content were evaluated. Results were analysed using ANOVA (p<0.05, Tukey’s test).

It was determined that higher amounts of zinc in the nutrient solution resulted in significantly higher levels of zinc in all three crops (p<0.05), with increases of 205% in pea microgreens, 264% in babyleaf kale and 217% in kale microgreens compared to the control plants. Higher amounts of iron in the nutrient solution resulted in significantly higher levels of iron only in pea microgreens, with an increase of 38% (p<0.05). Neither dosing regimen negatively influenced the overall crop performance.

These results suggest that the three different crops are suitable for soilless biofortification with zinc and iron, although pea microgreens were the only crop that had a significant increase in iron upon iron-dosing.
Beyond Crisis and Emergency: Climate Change as a Political Epic
Authors: Maloy J. S.
Published: October 2024

The available choices of political responses to disruption in the global climatic system depend in part on how the problem is conceptualized. Researchers and policymakers often invoke a “climate crisis” or “climate emergency,” but such language fits poorly with current knowledge of the problem's physical causes and social impacts. This article argues that climate change is instead more like a political epic. It involves neither sudden onset, as in the concept of emergency, nor decisive resolution, as in the concept of crisis, but rather a protracted ordeal of (temporally) obscure origins and uncertain outcomes. This alternative ontology of climate change highlights its novel temporal properties, including unusually slow-moving or time-lagged causal dynamics, with unsettling implications for academic research on the climatic-institutional nexus. Normatively, it undermines arguments for democracies’ environmental superiority over autocracies that rely on the former's general superiority at resolving crises and responding to emergencies. At the same time, some new arguments for democratic distributions of power become possible within the epic frame. More broadly, embracing the assumption of epic climate change may redirect attention from Promethean, managerial, or technocratic solutions to questions about which values or identities deserve preservation amid presumptively interminable and imperfectly remediable sources of disorder.
LA VERSION ARABE DE LA MESURE DU CERCLE D'ARCHIMÈDE I
Authors: Rashed Roshdi
Published: October 2024

Depuis son édition par Heiberg au XIXe s., on savait que le texte grec de La mesure du cercle d'Archimède qui nous est parvenu est fautif, altéré par l'intervention d'un compilateur. Pour certaines de ses parties au moins, il est donc d'une authenticité douteuse. Plus récemment, l'examen de la traduction latine (au IXe siècle) de la traduction arabe de ce texte a permis de conclure que le manuscrit grec traduit appartient à une tradition textuelle meilleure et plus ancienne que le texte édité par Heiberg. Dans cette étude, on trouve l'editio princeps de la traduction arabe de La mesure du cercle, sa première traduction et une analyse historique et mathématique. Les nombreuses lectures de cette traduction faites au cours des siècles ont inspiré plusieurs « rédactions ». Trois d'entre elles seront éditées, traduites et examinées dans une prochaine étude.
TWO QUESTIONS: THE MASʾALATĀN AND THE AVICENNIAN CORPUS
Authors: Lánczky István
Published: October 2024

This article brings to light a previously unedited short treatise, the Masʾalatān (Two Questions), attributed to Avicenna (d. 1037). While the earliest witness to the text is the Ayasofya 4853 manuscript, containing a substantial portion of Avicenna's Nachlass, some of which is integrated into the Mubāḥaṯāt and Taʿlīqāt, the Masʾalatān has remained a standalone work with limited circulation. Consequently, the primary concern revolves around the verification of its authenticity and its feasibility given the available data. This article presents a critical edition of the text alongside a parallel translation but it also serves as a case study on the possibilities of authorship verification. It also compiles information from codicology, nevertheless, it primarily focuses on the commentary that analyses and compares the arguments to Avicenna's unquestionably authentic solutions. The first question addresses whether every existent is spatially located, while the second explores the impossibility of an actual infinite body. The commentary endeavors to interpret the text against the cultural and theological background that may have inspired such inquiries, meanwhile also seeks to address its later influence. In addition to unveiling a hitherto unseen text to the scholarly community for further research, it also offers an insight into the limitations of authorship attribution.
Rice cultivar tolerance to florpyrauxifen-benzyl spray-applied vs. coated on urea
Authors: Cotter Bodie L. , Norsworthy Jason K. , Butts Thomas R. , Roberts Trenton L. , Mauromoustakos Andy
Published: October 2024

Complaints regarding the sensitivity of rice to florpyrauxifen-benzyl and off-target movement of the herbicide occurred following its commercial launch in 2018 in the midsouthern United States. These two concerns encouraged the exploration of an alternative application method for florpyrauxifen-benzyl in rice. A field study was conducted in 2020 and 2021 to determine if coating florpyrauxifen-benzyl on urea would reduce negative impacts of the herbicide to rice. Five commercial rice lines were evaluated: ‘Diamond’, ‘Titan’, ‘RT7321 FP’, ‘RT7521 FP’, and ‘XP753’. Florpyrauxifen-benzyl coated on urea at a 2× rate (60 g ai ha–1) reduced rice injury in one of five commercial rice lines in 2020 and four of five commercial rice lines in 2021, compared to spray applications at the same rate. In 2020, ‘RT7521 FP’ exhibited a 17-percentage point injury reduction when coating florpyrauxifen-benzyl on urea at a 2× rate vs. the same rate sprayed. In 2021, rice injury was reduced by 26, 10, and 27 percentage points in the commercial rice lines ‘Diamond’, ‘Titan’, and ‘XP753’, respectively, following coated urea vs. spray applications at 4 wk after treatment (WAT). ‘XP753’ exhibited reduced injury (15 percentage points) by coating florpyrauxifen-benzyl at a 1× rate (30 g ai ha–1) 4 WAT in 2021, and another, ‘Diamond’, had comparable groundcover to nontreated plots when florpyrauxifen-benzyl was coated on urea at a 1× rate rather than the reductions observed from the spray application at a 2× rate. Yield differences were a function of urea rate rather than application method, where in six out of ten instances greater rough rice grain yield occurred at the higher rate. Findings from this experiment indicate that coating florpyrauxifen-benzyl on urea can reduce the amount of injury observed, especially in areas of overlap where you would have a 2× rate.
Change in Wind Renewable Energy Potential Under Stratospheric Aerosol Injections
Authors: Baur Susanne , Sanderson Benjamin M. , Séférian Roland , Terray Laurent
Published: October 2024

Wind renewable energy (WRE) is an essential component of the global sustainable energy portfolio. Recently, there has been increasing discussion on the potential supplementation of this conventional mitigation portfolio with Solar Radiation Modification (SRM). However, the impact of SRM on conventional mitigation measures has received limited attention to date. In this study, we explore one part of this impact, the potential effect of one type of SRM, Stratospheric Aerosol Injections (SAI), on WRE. Using hourly output from the Earth System Model CNRM‐ESM2‐1, we compare WRE potential under a medium emission scenario (SSP245) and a high emission scenario (SSP585) with an SRM scenario that has SSP585 baseline conditions and uses SAI to offset warming to approximately SSP245 global warming levels. Our results suggest that SAI may affect surface wind resources by modifying large‐scale circulation patterns, such as a significant poleward jet‐shift in the Southern Hemisphere. The modeled total global WRE potential is negligibly reduced under SAI compared to the SSP‐scenarios. However, regional trends are highly variable, with large increases and decreases in WRE potential frequently reaching 12% across the globe with SAI. This study highlights potential downstream effects of SRM on climatic elements, such as wind patterns, and offers perspectives on its implications for our mitigation efforts.
A Pirate River May Be Giving Mount Everest a Boost
Authors: Scharping Nathaniel
Published: October 2024

Rapid erosion can cause mountains to rise—even the world’s tallest peak.
Rapid Acidification of the Arctic Chukchi Sea Waters Driven by Anthropogenic Forcing and Biological Carbon Recycling
Authors: Qi Di , Wu Yingxu , Chen Liqi , Cai Wei‐Jun , Yu Shujie , Ouyang Zhangxian , Zhang Yixing , Anderson Leif G. , Feely Richard A. , Zhuang Yanpei , Lin Hongmei , Lei Ruibo , Bi Haibo
Published: October 2024

The acidification of coastal waters is distinguished from the open ocean because of much stronger synergistic effects between anthropogenic forcing and local biogeochemical processes. However, ocean acidification research is still rather limited in polar coastal oceans. Here, we present a 16 year (2002–2018) observational dataset in the Chukchi Sea during the rapid sea‐ice melting season to determine the long‐term changes in pH and aragonite saturation state (Ωarag). We found that pH and Ωarag significantly declined in the water column with average rates of −0.0095 ± 0.0027 years−1 and −0.0333 ± 0.0098 years−1, respectively, and are 4–6 times faster than those solely due to increasing atmospheric CO2. We attributed the rapid acidification to the increased dissolved inorganic carbon owing to a combination of ice melt‐induced increased atmospheric CO2 invasion and subsurface remineralization induced by a stronger surface biological production as a result of the increased inflow of the nutrient‐rich Pacific water.
Inertia of Ionospheric Conductance During Electron Precipitation Events
Authors: Khazanov George V. , Kang Suk‐Bin , Glocer Alex
Published: October 2024

Using the SuperThermal Electron Transport (STET) model coupled with the Super‐thermal Proton Electron Atomic Hydrogen—tRansport in the Ionosphere and Thermosphere (SPEAH‐RIT) codes, we demonstrate that temporal variability of ionospheric conductance is defined by several time scales: the temporal variations of the magnetospheric source, the start time of electron precipitation, and the termination of the corresponding source. In these cases, the time scales are defined by dissipation of energetic electrons and effective recombination processes. The results presented in this paper were applied in the regions of pulsating aurora and polar arcs, demonstrating the fact that ionospheric conductance requires some time to form and decay. These time delays constitute an effective “inertia” in the conductance calculation which is not accounted for in many global models which assume an instantaneous connection between precipitation and conductance. Ionospheric conductance inertia influences the temporal variation in ionospheric and magnetospheric electric fields, and as a result, impacts magnetosphere‐ionosphere (MI) dynamics on a global scale.
Impact of EMIC Waves on Electron Flux Dropouts Measured by GPS Spacecraft: Insights From ELFIN
Authors: Mourenas Didier , Artemyev Anton V. , Zhang Xiao‐Jia , Angelopoulos Vassilis
Published: October 2024

Although the effects of electromagnetic ion cyclotron (EMIC) waves on the dynamics of the Earth's outer radiation belt have been a topic of intense research for more than 20 years, their influence on rapid dropouts of electron flux has not yet been fully assessed. Here, we make use of contemporaneous measurements on the same ‐shell of trapped electron fluxes at 20,000 km altitude by Global Positioning System (GPS) spacecraft and of trapped and precipitating electron fluxes at 450 km altitude by Electron Losses and Fields Investigation (ELFIN) CubeSats in 2020–2022, to investigate the impact of EMIC wave‐driven electron precipitation on the dynamics of the outer radiation belt below the last closed drift shell of trapped electrons. During six of the seven selected events, the strong 1–2 MeV electron precipitation measured at ELFIN, likely driven by EMIC waves, occurs within 1–2 hr from a dropout of relativistic electron flux at GPS spacecraft. Using quasi‐linear diffusion theory, EMIC wave‐driven pitch angle diffusion rates are inferred from ELFIN measurements, allowing us to quantitatively estimate the corresponding flux drop based on typical spatial and temporal extents of EMIC waves. We find that EMIC wave‐driven electron precipitation alone can account for the observed dropout magnitude at 1.5–3 MeV during all events and that, when dropouts extend down to 0.5 MeV, a fraction of electron loss may sometimes be due to EMIC waves. This suggests that EMIC wave‐driven electron precipitation could modulate dropout magnitude above 1 MeV in the heart of the outer radiation belt.
Impact of WindBorne Observation Assimilation on Prediction of a TPV Merger Case From THINICE
Authors: Johnson Aaron , Wang Xuguang , Hutchinson Todd , Creus‐Costa Joan
Published: October 2024

The impact of assimilating in situ temperature, moisture and wind observations from a WindBorne Systems balloon, with long duration and adjustable ballast, is evaluated using a case study from the 2022 THINICE field campaign. A case is selected wherein the WindBorne balloon directly sampled a jet streak associated with a tropopause polar vortex (TPV). The observed TPV merged with another TPV at the same time as a downstream Arctic cyclone (AC) redeveloped eastward. The case is used to better understand the role of the observed TPV in the evolution of the downstream AC. The assimilation of the WindBorne observations improves the forecast track and amplitude of the TPV during the ∼1 day forecast period that the TPV can be tracked as a distinct feature. The root mean square error of temperature at 350 hPa is improved by the WindBorne assimilation throughout the 2.5 day forecast period. The surface cyclone track forecast is improved by the WindBorne assimilation during the period of eastward redevelopment of the surface cyclone, and the sea level pressure RMSE in the surrounding region is reduced during the first ∼1.5 days of forecast lead time. Results demonstrate the capability of the long‐duration controllable WindBorne balloons to improve the analysis of the TPV associated with the jet streak, leading to improved forecast of both tropopause‐level and surface pressure features. Additionally, the importance of observing the upstream TPV amplitude for improving forecasts of the process of TPV merging and its impact on the evolution and longevity of the mature AC is confirmed.
Dichotomous intronic polyadenylation profiles reveal multifaceted gene functions in the pan-cancer transcriptome
Authors: Sun Jiao , Kim Jin-Young , Jun Semo , Park Meeyeon , de Jong Ebbing , Chang Jae-Woong , Cheng Sze , Fan Deliang , Chen Yue , Griffin Timothy J. , Lee Jung-Hee , You Ho Jin , Zhang Wei , Yong Jeongsik
Published: October 2024

Alternative cleavage and polyadenylation within introns (intronic APA) generate shorter mRNA isoforms; however, their physiological significance remains elusive. In this study, we developed a comprehensive workflow to analyze intronic APA profiles using the mammalian target of rapamycin (mTOR)-regulated transcriptome as a model system. Our investigation revealed two contrasting effects within the transcriptome in response to fluctuations in cellular mTOR activity: an increase in intronic APA for a subset of genes and a decrease for another subset of genes. The application of this workflow to RNA-seq data from The Cancer Genome Atlas demonstrated that this dichotomous intronic APA pattern is a consistent feature in transcriptomes across both normal tissues and various cancer types. Notably, our analyses of protein length changes resulting from intronic APA events revealed two distinct phenomena in proteome programming: a loss of functional domains due to significant changes in protein length or minimal alterations in C-terminal protein sequences within unstructured regions. Focusing on conserved intronic APA events across 10 different cancer types highlighted the prevalence of the latter cases in cancer transcriptomes, whereas the former cases were relatively enriched in normal tissue transcriptomes. These observations suggest potential, yet distinct, roles for intronic APA events during pathogenic processes and emphasize the abundance of protein isoforms with similar lengths in the cancer proteome. Furthermore, our investigation into the isoform-specific functions of JMJD6 intronic APA events supported the hypothesis that alterations in unstructured C-terminal protein regions lead to functional differences. Collectively, our findings underscore intronic APA events as a discrete molecular signature present in both normal tissues and cancer transcriptomes, highlighting the contribution of APA to the multifaceted functionality of the cancer proteome.
Erythropoiesis: insights from a genomic perspective
Authors: Cha Hye Ji
Published: October 2024

Erythropoiesis, the process underlying the production of red blood cells, which are essential for oxygen transport, involves the development of hematopoietic stem cells into mature red blood cells. This review focuses on the critical roles of transcription factors and epigenetic mechanisms in modulating gene expression critical for erythroid differentiation. It emphasizes the significance of chromatin remodeling in ensuring gene accessibility, a key factor for the orderly progression of erythropoiesis. This review also discusses how dysregulation of these processes can lead to erythroid disorders and examines the promise of genome editing and gene therapy as innovative therapeutic approaches. By shedding light on the genomic regulation of erythropoiesis, this review suggests avenues for novel treatments for hematological conditions, underscoring the need for continued molecular studies to improve human health.
YAP promotes global mRNA translation to fuel oncogenic growth despite starvation
Authors: Hwang Daehee , Baek Seonguk , Chang Jeeyoon , Seol Taejun , Ku Bomin , Ha Hongseok , Lee Hyeonji , Cho Suhyeon , Roh Tae-Young , Kim Yoon Ki , Lim Dae-Sik
Published: October 2024

Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) play fundamental roles in stem/progenitor cell expansion during homeostasis, and their dysregulation often leads to tissue overgrowth. Here, we show that YAP activation is sufficient to overcome the restriction of global protein synthesis induced by serum starvation, enabling cells to sustain proliferation and survival despite an unfavorable environment. Mechanistically, YAP/TAZ selectively promoted the mTORC1-dependent translation of mRNAs containing 5′ terminal oligopyrimidine (5′TOP) motifs, ultimately increasing the cellular polysome content. Interestingly, DNA damage-inducible transcript 4 (DDIT4), a negative regulator of mTORC1, was upregulated by serum starvation but repressed by YAP/TAZ. DDIT4 was sufficient to suppress the translation and transformative potential of uveal melanoma cells, which are often serum unresponsive due to G protein mutations. Our findings reveal a vital role for protein synthesis as a key modality of YAP/TAZ-induced oncogenic transformation and indicate the potential for targeting mTORC1 or translation to treat YAP/TAZ-driven malignancies.
Revisiting T-cell adhesion molecules as potential targets for cancer immunotherapy: CD226 and CD2
Authors: Jo Yunju , Sim Hye-In , Yun Bohwan , Park Yoon , Jin Hyung-seung
Published: October 2024

Cancer immunotherapy aims to initiate or amplify immune responses that eliminate cancer cells and create immune memory to prevent relapse. Immune checkpoint inhibitors (ICIs), which target coinhibitory receptors on immune effector cells, such as CTLA-4 and PD-(L)1, have made significant strides in cancer treatment. However, they still face challenges in achieving widespread and durable responses. The effectiveness of anticancer immunity, which is determined by the interplay of coinhibitory and costimulatory signals in tumor-infiltrating immune cells, highlights the potential of costimulatory receptors as key targets for immunotherapy. This review explores our current understanding of the functions of CD2 and CD226, placing a special emphasis on their potential as novel agonist targets for cancer immunotherapy. CD2 and CD226, which are present mainly on T and NK cells, serve important functions in cell adhesion and recognition. These molecules are now recognized for their costimulatory benefits, particularly in the context of overcoming T-cell exhaustion and boosting antitumor responses. The importance of CD226, especially in anti-TIGIT therapy, along with the CD2‒CD58 axis in overcoming resistance to ICI or chimeric antigen receptor (CAR) T-cell therapies provides valuable insights into advancing beyond the current barriers of cancer immunotherapy, underscoring their promise as targets for novel agonist therapy.