bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Figures 1 - 8 from Telomere Length and Telomerase Activity Impact the UV Sensitivity Syndrome Xeroderma Pigmentosum C
Authors: Stout Gerdine J. , Blasco Maria A.
Published: April 2023

PDF file - 2543K, Average telomere length in MEFs derived from XpcTerc mouse model (S1); Telomere length in vivo (S2); Increased chromosomal instability in Xpc-/- background (S3); Pathology of XpcTerc mouse model and visualization of premature aging in XpcTerc mouse model (S4); Telomerase deficiency accelerates UV-induced carcinogenesis in Xpc-/- mice and chronic UV exposure leads to accelerated telomere shortening (S5); Representative images of immunohistochemical staining for Keratin 5, Keratin 10, Ki67, Active Caspase 3 (C3A), p53, p21, phosphorylated H2AX (ser 139) (yH2AX) and mutated p53- Pab240) in chronically irradiated mouse epidermis (S6); Schematic of CO-FISH telomere labeling resulting from leading-strand (red) and lagging-strand (green) DNA synthesis (S7); Activation of ALT (S8)
Supplementary Figure 4 from RNAi-Mediated Silencing of Myc Transcription Inhibits Stem-like Cell Maintenance and Tumorigenicity in Prostate Cancer
Authors: Civenni Gianluca , Malek Anastasia , Albino Domenico , Garcia-Escudero Ramon , Napoli Sara , Di Marco Stefano , Pinton Sandra , Sarti Manuela , Carbone Giuseppina M. , Catapano Carlo V.
Published: April 2023

PDF file - 28K, Expression of the cell surface markers CD44 and CD24 determined by qRT-PCR in PC3 and DU145 cells grown in adherent or sphere forming conditions.
Supplementary Figure 3 from RNAi-Mediated Silencing of Myc Transcription Inhibits Stem-like Cell Maintenance and Tumorigenicity in Prostate Cancer
Authors: Civenni Gianluca , Malek Anastasia , Albino Domenico , Garcia-Escudero Ramon , Napoli Sara , Di Marco Stefano , Pinton Sandra , Sarti Manuela , Carbone Giuseppina M. , Catapano Carlo V.
Published: April 2023

PDF file - 56K, Tumor-initiating capability of sorted subpopulations of PC3 cells.
Supplementary Figure 1 from RNAi-Mediated Silencing of Myc Transcription Inhibits Stem-like Cell Maintenance and Tumorigenicity in Prostate Cancer
Authors: Civenni Gianluca , Malek Anastasia , Albino Domenico , Garcia-Escudero Ramon , Napoli Sara , Di Marco Stefano , Pinton Sandra , Sarti Manuela , Carbone Giuseppina M. , Catapano Carlo V.
Published: April 2023

PDF file - 58K, Myc overexpression in primary prostate cancers.
Supplementary Figures 1 - 6 from Cancer Stem-like Cells Derived from Chemoresistant Tumors Have a Unique Capacity to Prime Tumorigenic Myeloid Cells
Authors: Yamashina Tsunaki , Baghdadi Muhammad , Yoneda Akihiro , Kinoshita Ichiro , Suzu Shinya , Dosaka-Akita Hirotoshi , Jinushi Masahisa
Published: April 2023

PDF file - 1118K, Supplementary Figure 1 (CSC activities of chemoresistant non-CSCs), Supplementary Figure 2 (Pro-inflammatory phenotypes of HCT116-derived chemoresistant CSCs), Supplementary Figure 3 (Chemoresistance drives CSCs to prime M2 macrophages by a cell-autonomous manner), Supplementary Figure 4 (The role of CSC-R on MDSC differentiation), Supplementary Figure 5 (The role of CD44+CD133+colon CSC-R-derived IRF5 on priming M2 macrophages), Supplementary Figure 6 (Monocytes primed by M-CSF from CSC-R are responsible ofr triggering CSC activities).
Supplementary Figure 1 from Loss of TGF-β Adaptor β2SP Activates Notch Signaling and SOX9 Expression in Esophageal Adenocarcinoma
Authors: Song Shumei , Maru Dipen M. , Ajani Jaffer A. , Chan Chia-Hsin , Honjo Soichiro , Lin Hui-Kuan , Correa Arlene , Hofstetter Wayne L. , Davila Marta , Stroehlein John , Mishra Lopa
Published: April 2023

PDF file - 481K, Effects of β2SP on Notch receptors, ligand and γ-secretase complex.
Supplementary Methods, Figures 1 - 8, Table 1 from TNRC9 Downregulates BRCA1 Expression and Promotes Breast Cancer Aggressiveness
Authors: Shan Jingxuan , DSouza Shoba P. , Bakhru Sasha , Al-Azwani Eman K. , Ascierto Maria L. , Sastry Konduru S. , Bedri Shahinaz , Kizhakayil Dhanya , Aigha Idil I. , Malek Joel , Al-Bozom Issam , Gehani Salah , Furtado Stacia , Mathiowitz Edith , Wang Ena , Marincola Francesco M. , Chouchane Lotfi
Published: April 2023

PDF file - 655K, Supplementary Figure 1. TNRC9 promoted cell proliferation in MDA-MB-231 breast cancer cells. Supplementary Figure 2. shRNA-mediated knockdown of TNRC9. Supplementary Figure 3. H&E staining of tumors (10�Magnification) from xenograft nude mice subcutaneously injected with control ZR-75-1cells (upper row I � V) were compared with those injected with TNRC9-depeltion ZR-75-1 cells (lower row VI � VIII, no palpable tumor in two mice). �-� represents 400μm. Supplementary Figure 4. Knocking-down TNRC9 sensitizes cancer cells to apoptosis signal. Supplementary Figure 5. BRCA1 and TNRC9 expression in TNRC9 abrogated and control cells. Supplementary Figure 6. The expression profile of TNRC9 knockdown MCF-7 cells. Supplementary Figure 7. In silico analysis of TNRC9 and BRCA1 gene expression among ovarian cancer patients. Supplementary Figure 8. The effects of TNRC9 on luciferase activity driven by BRCA1 promoter. Supplementary Table 1 The list of transcripts significantly altered in TNRC9 knockdown MCF-7 cells comparing to control MCF-7 cells
Supplementary Tables 1-2 from Dysregulation of Cholesterol Homeostasis in Human Prostate Cancer through Loss of ABCA1
Authors: Lee Byron H. , Taylor Margaret G. , Robinet Peggy , Smith Jonathan D. , Schweitzer Jessica , Sehayek Ephraim , Falzarano Sara M. , Magi-Galluzzi Cristina , Klein Eric A. , Ting Angela H.
Published: April 2023

PDF file - 27K, Supplementary Table 1. Primer information. Supplementary Table 2. ABCG1 and ABCA1 gene expression.
Supplementary Figure 3 from CLPTM1L Promotes Growth and Enhances Aneuploidy in Pancreatic Cancer Cells
Authors: Jia Jinping , Bosley Allen D. , Thompson Abbey , Hoskins Jason W. , Cheuk Adam , Collins Irene , Parikh Hemang , Xiao Zhen , Ylaya Kris , Dzyadyk Marta , Cozen Wendy , Hernandez Brenda Y. , Lynch Charles F. , Loncarek Jadranka , Altekruse Sean F. , Zhang Lizhi , Westlake Christopher J. , Factor Valentina M. , Thorgeirsson Snorri , Bamlet William R. , Hewitt Stephen M. , Petersen Gloria M. , Andresson Thorkell , Amundadottir Laufey T.
Published: April 2023

PDF file - 279KB, Co-localization of CLPTM1L mutants (CLPTM1L-delta-Cterm and CLPTM1L-delta-Loop) with an ER marker, indicating a similar localization for WT and mutant CLPTM1L proteins to the endoplasmic reticulum.
Supplementary Figure 2 from CLPTM1L Promotes Growth and Enhances Aneuploidy in Pancreatic Cancer Cells
Authors: Jia Jinping , Bosley Allen D. , Thompson Abbey , Hoskins Jason W. , Cheuk Adam , Collins Irene , Parikh Hemang , Xiao Zhen , Ylaya Kris , Dzyadyk Marta , Cozen Wendy , Hernandez Brenda Y. , Lynch Charles F. , Loncarek Jadranka , Altekruse Sean F. , Zhang Lizhi , Westlake Christopher J. , Factor Valentina M. , Thorgeirsson Snorri , Bamlet William R. , Hewitt Stephen M. , Petersen Gloria M. , Andresson Thorkell , Amundadottir Laufey T.
Published: April 2023

PDF file - 33KB, CLPTM1L knock-down inhibits growth of pancreatic cancer cells in vitro.
Supplementary Methods and Figure Legend from STC1 Expression By Cancer-Associated Fibroblasts Drives Metastasis of Colorectal Cancer
Authors: Peña Cristina , Céspedes María Virtudes , Lindh Maja Bradic , Kiflemariam Sara , Mezheyeuski Artur , Edqvist Per-Henrik , Hägglöf Christina , Birgisson Helgi , Bojmar Linda , Jirström Karin , Sandström Per , Olsson Eleonor , Veerla Srinivas , Gallardo Alberto , Sjöblom Tobias , Chang Andy C.-M. , Reddel Roger R. , Mangues Ramón , Augsten Martin , Östman Arne
Published: April 2023

PDF file - 144K
Supplementary Figure 1 from CLPTM1L Promotes Growth and Enhances Aneuploidy in Pancreatic Cancer Cells
Authors: Jia Jinping , Bosley Allen D. , Thompson Abbey , Hoskins Jason W. , Cheuk Adam , Collins Irene , Parikh Hemang , Xiao Zhen , Ylaya Kris , Dzyadyk Marta , Cozen Wendy , Hernandez Brenda Y. , Lynch Charles F. , Loncarek Jadranka , Altekruse Sean F. , Zhang Lizhi , Westlake Christopher J. , Factor Valentina M. , Thorgeirsson Snorri , Bamlet William R. , Hewitt Stephen M. , Petersen Gloria M. , Andresson Thorkell , Amundadottir Laufey T.
Published: April 2023

PDF file - 402KB, Localization of CLPTM1L to the ER in mouse iMCD3 cells.
Supplementary Figure 6 from STC1 Expression By Cancer-Associated Fibroblasts Drives Metastasis of Colorectal Cancer
Authors: Peña Cristina , Céspedes María Virtudes , Lindh Maja Bradic , Kiflemariam Sara , Mezheyeuski Artur , Edqvist Per-Henrik , Hägglöf Christina , Birgisson Helgi , Bojmar Linda , Jirström Karin , Sandström Per , Olsson Eleonor , Veerla Srinivas , Gallardo Alberto , Sjöblom Tobias , Chang Andy C.-M. , Reddel Roger R. , Mangues Ramón , Augsten Martin , Östman Arne
Published: April 2023

PDF file - 6235K, "Route-specific" analysis of metastases.
Supplementary Table 1 from Silencing of the miR-17∼92 Cluster Family Inhibits Medulloblastoma Progression
Authors: Murphy Brian L. , Obad Susanna , Bihannic Laure , Ayrault Olivier , Zindy Frederique , Kauppinen Sakari , Roussel Martine F.
Published: April 2023

PDF file - 289K, Oligonucleotide sequences cloned into the pmirGLO vector (S1).
Supplementary Figure 2 from STC1 Expression By Cancer-Associated Fibroblasts Drives Metastasis of Colorectal Cancer
Authors: Peña Cristina , Céspedes María Virtudes , Lindh Maja Bradic , Kiflemariam Sara , Mezheyeuski Artur , Edqvist Per-Henrik , Hägglöf Christina , Birgisson Helgi , Bojmar Linda , Jirström Karin , Sandström Per , Olsson Eleonor , Veerla Srinivas , Gallardo Alberto , Sjöblom Tobias , Chang Andy C.-M. , Reddel Roger R. , Mangues Ramón , Augsten Martin , Östman Arne
Published: April 2023

PDF file - 1263K, PDGF-dependent stimulation by MEFs of colon cancer cell invasion. STC1-dependent stimulation by fibroblasts of colon cancer cell migration.
Supplementary Figure 1 from STC1 Expression By Cancer-Associated Fibroblasts Drives Metastasis of Colorectal Cancer
Authors: Peña Cristina , Céspedes María Virtudes , Lindh Maja Bradic , Kiflemariam Sara , Mezheyeuski Artur , Edqvist Per-Henrik , Hägglöf Christina , Birgisson Helgi , Bojmar Linda , Jirström Karin , Sandström Per , Olsson Eleonor , Veerla Srinivas , Gallardo Alberto , Sjöblom Tobias , Chang Andy C.-M. , Reddel Roger R. , Mangues Ramón , Augsten Martin , Östman Arne
Published: April 2023

PDF file - 2355K, Analyses of PDGF β-receptor expression in LIM1215 co-cultured with BJHTERT fibroblasts and PDGFβR ligand production of colon tumors cells. Basal migration levels and migration levels with co-cultured stimulated PDGF fibroblasts of colon cancer cell lines.
Supplementary Figures 1-3 from Characterization of a Novel PERK Kinase Inhibitor with Antitumor and Antiangiogenic Activity
Authors: Atkins Charity , Liu Qi , Minthorn Elisabeth , Zhang Shu-Yun , Figueroa David J. , Moss Katherine , Stanley Thomas B. , Sanders Brent , Goetz Aaron , Gaul Nathan , Choudhry Anthony E. , Alsaid Hasan , Jucker Beat M. , Axten Jeffrey M. , Kumar Rakesh
Published: April 2023

Supplementary Figures 1-3 PDF file - 245K, Supplementary Figure 1: Dose-dependent pharmacodynamic effect of GSK2656157 on PERK in mouse pancreas. Supplementary Figure 2: Specificity of phospho-PERK antibody in mouse cells. Supplementary Figure 3: Effect of PERK inhibitor on RNA expression in tumor xenografts.
Supplementary Figure Legend from ST6Gal-I Protein Expression Is Upregulated in Human Epithelial Tumors and Correlates with Stem Cell Markers in Normal Tissues and Colon Cancer Cell Lines
Authors: Swindall Amanda F. , Londoño-Joshi Angelina I. , Schultz Matthew J. , Fineberg Naomi , Buchsbaum Donald J. , Bellis Susan L.
Published: April 2023

PDF file - 23K
Supplementary Figure 1 from ST6Gal-I Protein Expression Is Upregulated in Human Epithelial Tumors and Correlates with Stem Cell Markers in Normal Tissues and Colon Cancer Cell Lines
Authors: Swindall Amanda F. , Londoño-Joshi Angelina I. , Schultz Matthew J. , Fineberg Naomi , Buchsbaum Donald J. , Bellis Susan L.
Published: April 2023

PDF file - 166K, Validation of ST6Gal-I antibody
Supplementary Table 8 from Differential Effects of RUNX2 on the Androgen Receptor in Prostate Cancer: Synergistic Stimulation of a Gene Set Exemplified by SNAI2 and Subsequent Invasiveness
Authors: Little Gillian H. , Baniwal Sanjeev K. , Adisetiyo Helty , Groshen Susan , Chimge Nyam-Osor , Kim Sun Young , Khalid Omar , Hawes Debra , Jones Jeremy O. , Pinski Jacek , Schones Dustin E. , Frenkel Baruch
Published: April 2023

XLSX file - 13KB, Association of RUNX2, AR and SNAI2 with clinical recurrence.
Supplementary Figures 1 - 5 from API5 Confers Tumoral Immune Escape through FGF2-Dependent Cell Survival Pathway
Authors: Noh Kyung Hee , Kim Seok-Ho , Kim Jin Hee , Song Kwon-Ho , Lee Young-Ho , Kang Tae Heung , Han Hee Dong , Sood Anil K. , Ng Joanne , Kim Kwanghee , Sonn Chung Hee , Kumar Vinay , Yee Cassian , Lee Kyung-Mi , Kim Tae Woo
Published: April 2023

PDF file - 1008KB, mRNA and protein expression of Api5 in TC-1/P0 and TC-1/P3 A17 cells (S1). Api5 expression in murine tumors and their immune resistance (S2). In vitro Generation and Characterization of KKM MART1-specific CTL clone (S3). Characterization of antigen presenting capacity of A375/no insert and A375/API5 cells in vitro (S4). API5 activates FGFR1 signaling pathway (S5).
Supplementary Table 5 from Differential Effects of RUNX2 on the Androgen Receptor in Prostate Cancer: Synergistic Stimulation of a Gene Set Exemplified by SNAI2 and Subsequent Invasiveness
Authors: Little Gillian H. , Baniwal Sanjeev K. , Adisetiyo Helty , Groshen Susan , Chimge Nyam-Osor , Kim Sun Young , Khalid Omar , Hawes Debra , Jones Jeremy O. , Pinski Jacek , Schones Dustin E. , Frenkel Baruch
Published: April 2023

XLSX file - 16KB, Dox induced expression values of Type II genes in the presence or absence of DHT.
Supplementary Figure 8 from Doxorubicin Eliminates Myeloid-Derived Suppressor Cells and Enhances the Efficacy of Adoptive T-Cell Transfer in Breast Cancer
Authors: Alizadeh Darya , Trad Malika , Hanke Neale T. , Larmonier Claire B. , Janikashvili Nona , Bonnotte Bernard , Katsanis Emmanuel , Larmonier Nicolas
Published: April 2023

PDF file - 46K, Characterization of in vitro generated Th1 and Th17 lymphocytes.
Supplementary Methods, Figures 1 - 5, Table 1 from Id-1 Is a Key Transcriptional Regulator of Glioblastoma Aggressiveness and a Novel Therapeutic Target
Authors: Soroceanu Liliana , Murase Ryuichi , Limbad Chandani , Singer Eric , Allison Juanita , Adrados Isabel , Kawamura Rumi , Pakdel Arash , Fukuyo Yayoi , Nguyen Daniel , Khan Sabeena , Arauz Robert , Yount Garret L. , Moore Dan H. , Desprez Pierre-Yves , McAllister Sean D.
Published: April 2023

PDF file - 2804K, Supplementary Figure 1. Id-1 levels are increased in the CD133+ GBM cells. Supplementary Figure 2. Id-1 knockdown inhibits U251 cell neurosphere formation. Supplementary Figure 3. Id-1 knockdown in GBM cells increases survival in an orthotopic mouse model. Supplementary Figure 4. CBD treatment reduces phosphorylation of several kinases involved in cell survival and aggressiveness. Supplementary Figure 5. CBD reduces tumor progression in vivo. Supplementary Table 1. Primary cultures analyzed by immunofluorescence or Western blot.
Supplementary Figure 4 from Anti-CD20 Antibody Promotes Cancer Escape via Enrichment of Tumor-Evoked Regulatory B Cells Expressing Low Levels of CD20 and CD137L
Authors: Bodogai Monica , Lee Chang Catalina , Wejksza Katarzyna , Lai Jinping , Merino Maria , Wersto Robert P. , Gress Ronald E. , Chan Andrew C. , Hesdorffer Charles , Biragyn Arya
Published: April 2023

PDF file - 119K, Targeted tBreg inactivation with BLC-arp/CpG-ODN
Supplementary Figure 3 from Sunlight UV-Induced Skin Cancer Relies upon Activation of the p38α Signaling Pathway
Authors: Liu Kangdong , Yu Donghoon , Cho Yong-Yeon , Bode Ann M. , Ma Weiya , Yao Ke , Li Shengqing , Li Jixia , Bowden G. Tim , Dong Ziming , Dong Zigang
Published: April 2023

PDF file - 309K, The protein phosphorylation spectrum activated by UVA, UVB or SUV irradiation. N/TERT-1 cells were irradiated with UVA (60 kJ/m2), UVB (3.6 kJ/m2) or SUV (60 kJ UVA/m2/3.6 kJ UVB/m2). Protein extracts (500 μg) were used for phospho-kinase protein array analysis. Array spots were visualized by ECL kit. The density of the each duplicated array spot in Figure 3A was measured as described in Materials and Methods. The table shows the fold change in SUV-induced phosphorylation of all 46 kinases and transcription factors compared to untreated control (i.e., value of 1). Data are shown as an average of duplicate samples.
Supplementary Table 1 from Prooncogenic Factors miR-23b and miR-27b Are Regulated by Her2/Neu, EGF, and TNF-α in Breast Cancer
Authors: Jin Lianjin , Wessely Oliver , Marcusson Eric G. , Ivan Cristina , Calin George A. , Alahari Suresh K.
Published: April 2023

PDF file - 30K, Supplementary Table 1: The potential target genes of miR-23b searched by the PicTar, TargetScan, and miRanda online tools.
Supplementary Figure 3-2 from Erlotinib Prolongs Survival in Pancreatic Cancer by Blocking Gemcitabine-Induced MAPK Signals
Authors: Miyabayashi Koji , Ijichi Hideaki , Mohri Dai , Tada Motohisa , Yamamoto Keisuke , Asaoka Yoshinari , Ikenoue Tsuneo , Tateishi Keisuke , Nakai Yousuke , Isayama Hiroyuki , Morishita Yasuyuki , Omata Masao , Moses Harold L. , Koike Kazuhiko
Published: April 2023

Supplementary Figure 3-2 PDF file - 172K, Gemcitabine-induced expression of EGFR ligands was dependent on active MAPK signaling in the lung cancer cells
Supplementary Figure 3 from xCT Inhibition Depletes CD44v-Expressing Tumor Cells That Are Resistant to EGFR-Targeted Therapy in Head and Neck Squamous Cell Carcinoma
Authors: Yoshikawa Momoko , Tsuchihashi Kenji , Ishimoto Takatsugu , Yae Toshifumi , Motohara Takeshi , Sugihara Eiji , Onishi Nobuyuki , Masuko Takashi , Yoshizawa Kunio , Kawashiri Shuichi , Mukai Makio , Asoda Seiji , Kawana Hiromasa , Nakagawa Taneaki , Saya Hideyuki , Nagano Osamu
Published: April 2023

PDF file - 695K, A, B, C and D. The effect of CD44 RNAi on xCT expression and GSH level in HNSCC cells. E. Immunoprecipitation analysis for XCT and CD44v interaction in HNSCC cells.
Supplementary Figure 2 from xCT Inhibition Depletes CD44v-Expressing Tumor Cells That Are Resistant to EGFR-Targeted Therapy in Head and Neck Squamous Cell Carcinoma
Authors: Yoshikawa Momoko , Tsuchihashi Kenji , Ishimoto Takatsugu , Yae Toshifumi , Motohara Takeshi , Sugihara Eiji , Onishi Nobuyuki , Masuko Takashi , Yoshizawa Kunio , Kawashiri Shuichi , Mukai Makio , Asoda Seiji , Kawana Hiromasa , Nakagawa Taneaki , Saya Hideyuki , Nagano Osamu
Published: April 2023

PDF file - 688K, A,B and C. The effect of retinoic acid and sulfasalazine on HNSCC cells. D. The effect of CD44 RNAi on retinoic acid sensitivity. E.The effect of CDDP and sulfasalazine on tumor growth formed by HSC-2 cells.
Supplementary Figure Legend from The HSP90 Inhibitor Ganetespib Synergizes with the MET Kinase Inhibitor Crizotinib in both Crizotinib-Sensitive and -Resistant MET-Driven Tumor Models
Authors: Miyajima Naoto , Tsutsumi Shinji , Sourbier Carole , Beebe Kristin , Mollapour Mehdi , Rivas Candy , Yoshida Soichiro , Trepel Jane B. , Huang Ying , Tatokoro Manabu , Shinohara Nobuo , Nonomura Katsuya , Neckers Len
Published: April 2023

PDF file - 93K
Supplementary Figure 7 from LSECtin Expressed on Melanoma Cells Promotes Tumor Progression by Inhibiting Antitumor T-cell Responses
Authors: Xu Feng , Liu Jing , Liu Di , Liu Biao , Wang Min , Hu Zhiyuan , Du Xuemei , Tang Li , He Fuchu
Published: April 2023

PDF file - 78KB, Supplementary Figure 7 Confirmation of LAG-3 expression on T cells.
Supplementary Figure 2 from Higher Frequencies of GARP+CTLA-4+Foxp3+ T Regulatory Cells and Myeloid-Derived Suppressor Cells in Hepatocellular Carcinoma Patients Are Associated with Impaired T-Cell Functionality
Authors: Kalathil Suresh , Lugade Amit A. , Miller Austin , Iyer Renuka , Thanavala Yasmin
Published: April 2023

PDF file - 115K, Supplementary Figure 2. Impact of chronic viral infection or pretreatment of HCC patients on Tregs.
Supplementary Video 1 from Interleukin 21–Induced Granzyme B–Expressing B Cells Infiltrate Tumors and Regulate T Cells
Authors: Lindner Stefanie , Dahlke Karen , Sontheimer Kai , Hagn Magdalena , Kaltenmeier Christof , Barth Thomas F.E. , Beyer Thamara , Reister Frank , Fabricius Dorit , Lotfi Ramin , Lunov Oleg , Nienhaus G. Ulrich , Simmet Thomas , Kreienberg Rolf , Möller Peter , Schrezenmeier Hubert , Jahrsdörfer Bernd
Published: April 2023

MOV file - 3136K, Supplemental Video 1. B cells transfer active GrB to T cells.
Supplementary Figure 3 from Distinct Effects of Ligand-Induced PDGFRα and PDGFRβ Signaling in the Human Rhabdomyosarcoma Tumor Cell and Stroma Cell Compartments
Authors: Ehnman Monika , Missiaglia Edoardo , Folestad Erika , Selfe Joanna , Strell Carina , Thway Khin , Brodin Bertha , Pietras Kristian , Shipley Janet , Östman Arne , Eriksson Ulf
Published: April 2023

PDF file - 34K, PDGFRα-positive RMS cell lines are responsive to PDGF-CC stimulation and express PDGF ligands. A, immunoblotting of PDGFRα tyrosine phosphorylation in RMS cell lines after PDGF-CC stimulation. B, cell proliferation in response to PDGF-CC stimulation. Data are presented � SD (**P<0.01, Student's t test). C, qRT-PCR analysis of PDGF ligand expression in PDGFRα-positive cell lines.
Supplementary Figure 8 from An Essential Requirement for the SCAP/SREBP Signaling Axis to Protect Cancer Cells from Lipotoxicity
Authors: Williams Kevin J. , Argus Joseph P. , Zhu Yue , Wilks Moses Q. , Marbois Beth N. , York Autumn G. , Kidani Yoko , Pourzia Alexandra L. , Akhavan David , Lisiero Dominique N. , Komisopoulou Evangelia , Henkin Amy H. , Soto Horacio , Chamberlain Brian T. , Vergnes Laurent , Jung Michael E. , Torres Jorge Z. , Liau Linda M. , Christofk Heather R. , Prins Robert M. , Mischel Paul S. , Reue Karen , Graeber Thomas G. , Bensinger Steven J.
Published: April 2023

PDF File - 90K, Graphical representation of method used to determine the relative contribution of de novo cholesterol and long chain fatty acids synthesis to the total cellular pool.
Supplementary Figure 5 from Bcl3 Selectively Promotes Metastasis of ERBB2-Driven Mammary Tumors
Authors: Wakefield Alison , Soukupova Jitka , Montagne Amelie , Ranger Jill , French Rhiannon , Muller William J. , Clarkson Richard W. E.
Published: April 2023

PDF file - 377K, Stem cell-like activity is not reduced by the suppression of Bcl3
Supplementary Figure 2 from Bcl3 Selectively Promotes Metastasis of ERBB2-Driven Mammary Tumors
Authors: Wakefield Alison , Soukupova Jitka , Montagne Amelie , Ranger Jill , French Rhiannon , Muller William J. , Clarkson Richard W. E.
Published: April 2023

PDF file - 269K, Primary tumour morphology and cell turnover kinetics are unaltered by Bcl3 deficiency
Supplementary Tables 1 and 2 from Mechanisms Promoting Escape from Mitotic Stress–Induced Tumor Cell Death
Authors: Sinnott Rebecca , Winters Leah , Larson Brittany , Mytsa Daniela , Taus Patrick , Cappell Kathryn M. , Whitehurst Angelique W.
Published: April 2023

XLSX - 4269K, Supplementary Table 1 lists viability scores from the pan-genomic siRNA screen. Supplementary Table 2 lists the high interest chemosensitizers and indicates those siRNA pools selected for secondary screening analysis.
Supplementary Table 1 from Pirfenidone Inhibits Pancreatic Cancer Desmoplasia by Regulating Stellate Cells
Authors: Kozono Shingo , Ohuchida Kenoki , Eguchi Daiki , Ikenaga Naoki , Fujiwara Kenji , Cui Lin , Mizumoto Kazuhiro , Tanaka Masao
Published: April 2023

PDF file - 75K, Supplementary Table 1: Primers used for quantitative RT-PCR.
Supplementary Figure 6 from Redox Modulation of Adjacent Thiols in VLA-4 by AS101 Converts Myeloid Leukemia Cells from a Drug-Resistant to Drug-Sensitive State
Authors: Layani-Bazar Adi , Skornick Itai , Berrebi Alain , Pauker Maor H. , Noy Elad , Silberman Alon , Albeck Michael , Longo Dan L. , Kalechman Yona , Sredni Benjamin
Published: April 2023

PDF file - 981K, Fig. S6: Inhibition of pAkt mediates AS101's activity involving chemotherapy-induced AML cell death as tested by subG1 accumulation.
Supplementary Figure Legend from High-Throughput Tyrosine Kinase Activity Profiling Identifies FAK as a Candidate Therapeutic Target in Ewing Sarcoma
Authors: Crompton Brian D. , Carlton Anne L. , Thorner Aaron R. , Christie Amanda L. , Du Jinyan , Calicchio Monica L. , Rivera Miguel N. , Fleming Mark D. , Kohl Nancy E. , Kung Andrew L. , Stegmaier Kimberly
Published: April 2023

PDF file - 17K
Supplementary Figure 6 from De Novo Design of a Tumor-Penetrating Peptide
Authors: Alberici Luca , Roth Lise , Sugahara Kazuki N. , Agemy Lilach , Kotamraju Venkata R. , Teesalu Tambet , Bordignon Claudio , Traversari Catia , Rizzardi Gian-Paolo , Ruoslahti Erkki
Published: April 2023

PDF file - 898K, iNGR does not increase the penetration of co-administered Evans blue dye into normal organs
Supplementary Methods, Figure Legends from A Chimeric Receptor with NKG2D Specificity Enhances Natural Killer Cell Activation and Killing of Tumor Cells
Authors: Chang Yu-Hsiang , Connolly John , Shimasaki Noriko , Mimura Kousaku , Kono Koji , Campana Dario
Published: April 2023

PDF file - 298K, SF1. Cytokine/chemokine secretion of mock- and NKG2D-DAP10-CD3-transduced NK cells from 3 donors after incubation with a biotin-conjugated anti-NKG2D agonistic antibody (clone 1D11; eBioscience) and anti-biotin beads (MACSiBeads; Miltenyi Biotec) (see also Fig. 4 and Supplementary Table S1). Supplemental Movie. Live cell confocal photography of mock- (left panel) and NKG2D-DAP10-CD3-transduced NK cells (right panel) co-cultured U2 OS osteosarcoma cells. NK cells were labeled with PKH26 (Sigma) before culture and appear red. Microscopy was performed with a Nikon TE2000E2 microscope equipped with a Nikon C1Si confocal using 488nm and 561nm DPSS lasers for excitation. Temperature was maintained at 37oC and CO2 at 5% using an environmental control chamber. Images were acquired with a Nikon 40x 1.3 NA DIC objective every 30s for 2hr using Nikon EZC1 software. Imaris (Bitplane Scientific Software) was used to analyze speed and displacement of NK cells. Supplementary Table S1. Cytokine/chemokine secretion (mean � SD pg/mL) after stimulation of mock- or NKG2D-DAP10-CD3-transduced NK cells with anti-NKG2Da.
Supplementary Figure 2 from De Novo Design of a Tumor-Penetrating Peptide
Authors: Alberici Luca , Roth Lise , Sugahara Kazuki N. , Agemy Lilach , Kotamraju Venkata R. , Teesalu Tambet , Bordignon Claudio , Traversari Catia , Rizzardi Gian-Paolo , Ruoslahti Erkki
Published: April 2023

PDF file - 404K, iNGR does not bind to CD13+ monocytes
Supplementary Figure 1 from De Novo Design of a Tumor-Penetrating Peptide
Authors: Alberici Luca , Roth Lise , Sugahara Kazuki N. , Agemy Lilach , Kotamraju Venkata R. , Teesalu Tambet , Bordignon Claudio , Traversari Catia , Rizzardi Gian-Paolo , Ruoslahti Erkki
Published: April 2023

PDF file - 166K, HUVECs express NGR and CendR motif receptors
Supplementary Figure Legend from Regulation of CD4+NKG2D+ Th1 Cells in Patients with Metastatic Melanoma Treated with Sorafenib: Role of IL-15Rα and NKG2D Triggering
Authors: Romero Ana I. , Chaput Nathalie , Poirier-Colame Vichnou , Rusakiewicz Sylvie , Jacquelot Nicolas , Chaba Kariman , Mortier Erwan , Jacques Yannick , Caillat-Zucman Sophie , Flament Caroline , Caignard Anne , Messaoudene Meriem , Aupérin Anne , Vielh Philippe , Dessen Philippe , Porta Camillo , Mateus Christine , Ayyoub Maha , Valmori Danila , Eggermont Alexander , Robert Caroline , Zitvogel Laurence
Published: April 2023

PDF file - 119K
Supplementary Figure 5 from Regulation of CD4+NKG2D+ Th1 Cells in Patients with Metastatic Melanoma Treated with Sorafenib: Role of IL-15Rα and NKG2D Triggering
Authors: Romero Ana I. , Chaput Nathalie , Poirier-Colame Vichnou , Rusakiewicz Sylvie , Jacquelot Nicolas , Chaba Kariman , Mortier Erwan , Jacques Yannick , Caillat-Zucman Sophie , Flament Caroline , Caignard Anne , Messaoudene Meriem , Aupérin Anne , Vielh Philippe , Dessen Philippe , Porta Camillo , Mateus Christine , Ayyoub Maha , Valmori Danila , Eggermont Alexander , Robert Caroline , Zitvogel Laurence
Published: April 2023

PDF file - 1795K, T-cell infiltration and MICA/B expression in metastatic melanoma.
Supplementary Figure 3 from Regulation of CD4+NKG2D+ Th1 Cells in Patients with Metastatic Melanoma Treated with Sorafenib: Role of IL-15Rα and NKG2D Triggering
Authors: Romero Ana I. , Chaput Nathalie , Poirier-Colame Vichnou , Rusakiewicz Sylvie , Jacquelot Nicolas , Chaba Kariman , Mortier Erwan , Jacques Yannick , Caillat-Zucman Sophie , Flament Caroline , Caignard Anne , Messaoudene Meriem , Aupérin Anne , Vielh Philippe , Dessen Philippe , Porta Camillo , Mateus Christine , Ayyoub Maha , Valmori Danila , Eggermont Alexander , Robert Caroline , Zitvogel Laurence
Published: April 2023

PDF file - 109K, CD4+CD8dim or CD4+NKG2D+ T cells can be found in other malignancies.
Supplementary Table 5 from Transcriptional Profiling of Melanoma Sentinel Nodes Identify Patients with Poor Outcome and Reveal an Association of CD30+ T Lymphocytes with Progression
Authors: Vallacchi Viviana , Vergani Elisabetta , Camisaschi Chiara , Deho Paola , Cabras Antonello D. , Sensi Marialuisa , De Cecco Loris , Bassani Niccolò , Ambrogi Federico , Carbone Antonino , Crippa Federica , Vergani Barbara , Frati Paola , Arienti Flavio , Patuzzo Roberto , Villa Antonello , Biganzoli Elia , Canevari Silvana , Santinami Mario , Castelli Chiara , Rivoltini Licia , Rodolfo Monica
Published: April 2023

XLSX file - 132K, Supplementary Table S5.CD30 expression in the PP.
Supplementary Figure 8 from Skin Tumorigenesis Stimulated by Raf Inhibitors Relies Upon Raf Functions That Are Dependent and Independent of ERK
Authors: Doma Eszter , Rupp Christian , Varga Andrea , Kern Florian , Riegler Bettina , Baccarini Manuela
Published: April 2023

PDF file - 185K, Effect of Rok inhibitors on K5‐SOS‐F+; C‐RafKO epithelia.
Supplementary Figure 3 from Skin Tumorigenesis Stimulated by Raf Inhibitors Relies Upon Raf Functions That Are Dependent and Independent of ERK
Authors: Doma Eszter , Rupp Christian , Varga Andrea , Kern Florian , Riegler Bettina , Baccarini Manuela
Published: April 2023

PDF file - 1000K, The Mek inhibitor trametinib prevents Ras‐ and Ras+Raf inhibitor‐induced tumorigenesis.
Supplementary Figure Legend from Targeting uPAR with Antagonistic Recombinant Human Antibodies in Aggressive Breast Cancer
Authors: LeBeau Aaron M. , Duriseti Sai , Murphy Stephanie T. , Pepin Francois , Hann Byron , Gray Joe W. , VanBrocklin Henry F. , Craik Charles S.
Published: April 2023

PDF file - 62K
Supplementary Figure 3 from MyoD Is a Tumor Suppressor Gene in Medulloblastoma
Authors: Dey Joyoti , Dubuc Adrian M. , Pedro Kyle D. , Thirstrup Derek , Mecham Brig , Northcott Paul A. , Wu Xiaochong , Shih David , Tapscott Stephen J. , LeBlanc Michael , Taylor Michael D. , Olson James M.
Published: April 2023

PDF file - 1235K, MyoD is expressed in proliferating tumor cells in SmoA1, SmoA2 and Ptch conditional knock out medulloblastoma mouse models.
Supplementary Tables 1 - 5, Figures 1 - 6 from Personalizing the Treatment of Pediatric Medulloblastoma: Polo-like Kinase 1 as a Molecular Target in High-Risk Children
Authors: Triscott Joanna , Lee Cathy , Foster Colleen , Manoranjan Branavan , Pambid Mary Rose , Berns Rachel , Fotovati Abbas , Venugopal Chitra , O'Halloran Katrina , Narendran Aru , Hawkins Cynthia , Ramaswamy Vijay , Bouffet Eric , Taylor Michael D. , Singhal Ash , Hukin Juliette , Rassekh Rod , Yip Stephen , Northcott Paul , Singh Sheila K. , Dunham Christopher , Dunn Sandra E.
Published: April 2023

PDF file - 685K, Supplementary Table S1. Summary of the pediatric MB patients included in the study Discovery cohort. Supplementary Table S2. Summary of the pediatric MB patients included in the study Validation cohort. Supplementary Table S3. PAM class prediction validation for MB subgroup assignment of Discovery cohort and cultured cells. Supplementary Table S4. PAM class prediction validation for MB subgroup assignment of Validation cohort. Supplementary Table S5. Univariate and multivariate analyses of clinical, pathological and biological endpoints in the Validation cohort. Supplementary Figure S1. MB survival in Validation cohort is stratified by molecular subtype. Supplementary Figure S2. PLK1 is invariably expressed between patient cohorts and between MB subgroups. Supplementary Figure S3. BI2536 sensitivity depends on PLK1 expression in primary MB cells. Supplementary Figure S4. MB cells lines expressing PLK1 experience cell cycle arrest and reduced proliferation with PLK1 inhibition. Supplementary Figure S5. MB cell PLK1 inhibition morphology using immunofluorescence. Supplementary Figure S6. MB cell lines treated with anti-cancer drugs.
Supplemental Figure Legends from MET and AXL Inhibitor NPS-1034 Exerts Efficacy against Lung Cancer Cells Resistant to EGFR Kinase Inhibitors Because of MET or AXL Activation
Authors: Rho Jin Kyung , Choi Yun Jung , Kim Seon Ye , Kim Tae Won , Choi Eun Kyung , Yoon Seon-Joo , Park Bu Man , Park Eunhye , Bae Jong Hwan , Choi Chang-Min , Lee Jae Cheol
Published: April 2023

Supplemental Figure Legends
Supplementary Figure Legends from Combined Anti-CD40 and Anti–IL-23 Monoclonal Antibody Therapy Effectively Suppresses Tumor Growth and Metastases
Authors: von Scheidt Bianca , Leung Patrick S.K. , Yong Michelle C.R. , Zhang Yu , Towne Jennifer E. , Smyth Mark J. , Teng Michele W.L.
Published: April 2023

PDF file - 102K
Supplementary Figure 6 from Combined Anti-CD40 and Anti–IL-23 Monoclonal Antibody Therapy Effectively Suppresses Tumor Growth and Metastases
Authors: von Scheidt Bianca , Leung Patrick S.K. , Yong Michelle C.R. , Zhang Yu , Towne Jennifer E. , Smyth Mark J. , Teng Michele W.L.
Published: April 2023

PDF file - 65K, Specific detection of intracellular IL-23 in LPS stimulated GM-CSF derived BMDCs.
Supplementary Figure 2 from Combined Anti-CD40 and Anti–IL-23 Monoclonal Antibody Therapy Effectively Suppresses Tumor Growth and Metastases
Authors: von Scheidt Bianca , Leung Patrick S.K. , Yong Michelle C.R. , Zhang Yu , Towne Jennifer E. , Smyth Mark J. , Teng Michele W.L.
Published: April 2023

PDF file - 91K, Combined anti-CD40/IL-23p19 mAb therapy suppresses spontaneous 4T1.2 lung metastases and is dependent on both NK cells and T cells.
Data Supplement from Optimal Effector Functions in Human Natural Killer Cells Rely upon Autocrine Bone Morphogenetic Protein Signaling
Authors: Robson Neil C. , Hidalgo Laura , McAlpine Tristan , Wei Heng , Martínez Víctor G. , Entrena Ana , Melen Gustavo J. , MacDonald Andrew S. , Phythian-Adams Alexander , Sacedón Rosa , Maraskovsky Eugene , Cebon Jonathan , Ramírez Manuel , Vicente Angeles , Varas Alberto
Published: April 2023

Supplemental Figure S3. Effects of dorsomorphin on NK cells phenotype and functionality.
Data Supplement from Optimal Effector Functions in Human Natural Killer Cells Rely upon Autocrine Bone Morphogenetic Protein Signaling
Authors: Robson Neil C. , Hidalgo Laura , McAlpine Tristan , Wei Heng , Martínez Víctor G. , Entrena Ana , Melen Gustavo J. , MacDonald Andrew S. , Phythian-Adams Alexander , Sacedón Rosa , Maraskovsky Eugene , Cebon Jonathan , Ramírez Manuel , Vicente Angeles , Varas Alberto
Published: April 2023

Supplemental Figure S4. Effects of DMH1 on NK cells IFN-y production and proliferation.
Data Supplement from Optimal Effector Functions in Human Natural Killer Cells Rely upon Autocrine Bone Morphogenetic Protein Signaling
Authors: Robson Neil C. , Hidalgo Laura , McAlpine Tristan , Wei Heng , Martínez Víctor G. , Entrena Ana , Melen Gustavo J. , MacDonald Andrew S. , Phythian-Adams Alexander , Sacedón Rosa , Maraskovsky Eugene , Cebon Jonathan , Ramírez Manuel , Vicente Angeles , Varas Alberto
Published: April 2023

Legend for Supplemental Figures S1-S5.
Supplementary Figures 1 - 7 from Induction of Immunoregulatory CD271+ Cells by Metastatic Tumor Cells That Express Human Endogenous Retrovirus H
Authors: Kudo-Saito Chie , Yura Masahiro , Yamamoto Ryusuke , Kawakami Yutaka
Published: April 2023

PDF file - 3218K, Figure S1. HERV-H expression is increased in cancers; Figure S2. HERV-H is involved in EMT of tumor cells (gene expression analysis); Figure S3. HERV-H+ tumor-derived CCL19 recruits CD4lowCD56lowCD271+ cells; Figure S4. The CD271+ cells generated by CCL19 and H17 derived from HERV-H+ tumor cells; Figure S5. Increase of CD271+ cells in CCL19+ tumor tissues of colon cancer patients; Figure S6. HERV-H knockdown inhibits both tumor metastasis and CD271+ cell increase in vivo; Figure S7. CCL19 blockade enhances anti-tumor immune responses in vivo possibly via decrease of CD271+ cells.
Supplemental Material and Methods, Figures 1 - 5 from An Integrated Computational Model of the Bone Microenvironment in Bone-Metastatic Prostate Cancer
Authors: Araujo Arturo , Cook Leah M. , Lynch Conor C. , Basanta David
Published: April 2023

Supplemental Figure 1 and Movie 1. Simulation images from the computational homeostatic basic multicellular unit (BMU) including parallel images of RANKL, TGFÃŽÂ² and bone derived factors including insulin like growth factor of the course of bone resorption and apposition. Supplemental Figure 2. Simulation images from the computational prostate tumorbone microenvironment model including parallel images of RANKL, TGFÃŽÂ² and bone derived factors of the course of 200 days. Supplemental Figure. 3. Plot shows that the behavior of the biological model (blue line) and computational model (black line) produce comparable outputs and show similar trends. Supplemental Figure 4. Determining the importance of MSC recruitment in the computational model. Supplemental Figure 5. Analysis of dosing efficacy in the computational model.
Supplementary Tables 1 - 3 from miRNA-491-5p and GIT1 Serve as Modulators and Biomarkers for Oral Squamous Cell Carcinoma Invasion and Metastasis
Authors: Huang Wei-Chieh , Chan Shih-Hsuan , Jang Te-Hsuan , Chang Jer-Wei , Ko Ying-Chin , Yen Tzu-Chen , Chiang Shang-Lun , Chiang Wei-Fan , Shieh Tien-Yu , Liao Chun-Ta , Juang Jyh-Lyh , Wang Hsueh-Chun , Cheng Ann-Joy , Lu Ya-Ching , Wang Lu-Hai
Published: April 2023

PDF file - 38K, Clinicopathologic features of patients (S1); Primers used in this study (S2); Venn diagram showing miR-491-5p targets through the TargetScan and DIANA-microT (S3).
Supplementary Figure Legend from miRNA-491-5p and GIT1 Serve as Modulators and Biomarkers for Oral Squamous Cell Carcinoma Invasion and Metastasis
Authors: Huang Wei-Chieh , Chan Shih-Hsuan , Jang Te-Hsuan , Chang Jer-Wei , Ko Ying-Chin , Yen Tzu-Chen , Chiang Shang-Lun , Chiang Wei-Fan , Shieh Tien-Yu , Liao Chun-Ta , Juang Jyh-Lyh , Wang Hsueh-Chun , Cheng Ann-Joy , Lu Ya-Ching , Wang Lu-Hai
Published: April 2023

PDF file - 104K
Supplementary Figure 6 from Compensatory Functions and Interdependency of the DNA-Binding Domain of BRCA2 with the BRCA1–PALB2–BRCA2 Complex
Authors: Al Abo Muthana , Dejsuphong Donniphat , Hirota Kouji , Yonetani Yasukazu , Yamazoe Mitsuyoshi , Kurumizaka Hitoshi , Takeda Shunichi
Published: April 2023

PDF file - 490K, BRCA2 mutant proteins stability and distribution.
Supplementary Figure 1 from Compensatory Functions and Interdependency of the DNA-Binding Domain of BRCA2 with the BRCA1–PALB2–BRCA2 Complex
Authors: Al Abo Muthana , Dejsuphong Donniphat , Hirota Kouji , Yonetani Yasukazu , Yamazoe Mitsuyoshi , Kurumizaka Hitoshi , Takeda Shunichi
Published: April 2023

PDF file - 38K, Generation of PALB2-/- and BRCA2-/-/PALB2-/- DT40 cells.
Supplementary Figure 2 from Curcumin Targets Breast Cancer Stem–like Cells with Microtentacles That Persist in Mammospheres and Promote Reattachment
Authors: Charpentier Monica S. , Whipple Rebecca A. , Vitolo Michele I. , Boggs Amanda E. , Slovic Jana , Thompson Keyata N. , Bhandary Lekhana , Martin Stuart S.
Published: April 2023

PDF file - 103K, Vehicle-treated BT-549s form significantly more mammospheres than BT-549s treated with 50microM curcumin.
Supplementary Figures 1 - 2 from MDR1 Synonymous Polymorphisms Alter Transporter Specificity and Protein Stability in a Stable Epithelial Monolayer
Authors: Fung King Leung , Pan James , Ohnuma Shinobu , Lund Paul E. , Pixley Jessica N. , Kimchi-Sarfaty Chava , Ambudkar Suresh V. , Gottesman Michael M.
Published: April 2023

PDF file - 2334K, SF1. Human P-gp is glycosylated in the LLC-PK1 cell line. SF2. Complete inhibition of drug efflux by P-gp wild-type and drug efflux of P-gp variants with high concentrations of a P-gp inhibitor.
Supplementary Figure 4 from Cancer Cells Exploit eIF4E2-Directed Synthesis of Hypoxia Response Proteins to Drive Tumor Progression
Authors: Uniacke James , Kishan Perera J. , Lachance Gabriel , Francisco Camille B. , Lee Stephen
Published: April 2023

PDF file - 1124K, Normal cells require eIF4E2-directed protein synthesis to survive and proliferate under hypoxia.
Supplementary Figures 1 through 9 from ALCAM/CD166 Is a TGF-β–Responsive Marker and Functional Regulator of Prostate Cancer Metastasis to Bone
Authors: Hansen Amanda G. , Arnold Shanna A. , Jiang Ming , Palmer Trenis D. , Ketova Tatiana , Merkel Alyssa , Pickup Michael , Samaras Susan , Shyr Yu , Moses Harold L. , Hayward Simon W. , Sterling Julie A. , Zijlstra Andries
Published: April 2023

PDF - 1790K, ALCAM expression is upregulated in response to the loss of ECadherin (S1); TGFbeta-induced shedding (S2); ALCAM serum half-life in mice (S3); ALCAM shedding by prostate and breast cancer cells in vitro and in vivo (S4); Compound-32/ADAM17 inhibitor dosing in vivo (S5); TGFbeta-induced migration is abrogated by the loss of ALCAM in breast and lung cancer cells (S6); Representative TRAcP stained bone lesion created by PC3 shControl and shALCAM after intratibial injection into immunodeficient mice (S7); Immune response modulation and wound healing does not effect serum ALCAM (S8); Graph represents tumor cell proliferation over time as assessed by total cell counts over 72 hours (S9).
Supplementary Figure 5 from Blocking eIF5A Modification in Cervical Cancer Cells Alters the Expression of Cancer-Related Genes and Suppresses Cell Proliferation
Authors: Mémin Elisabeth , Hoque Mainul , Jain Mohit R. , Heller Debra S. , Li Hong , Cracchiolo Bernadette , Hanauske-Abel Hartmut M. , Pe'ery Tsafi , Mathews Michael B.
Published: April 2023

PDF - 109K, Fig. S5. EF-P signals in target protein sequences.
Supplementary Figure 5 from Cofilin Drives Cell-Invasive and Metastatic Responses to TGF-β in Prostate Cancer
Authors: Collazo Joanne , Zhu Beibei , Larkin Spencer , Martin Sarah K. , Pu Hong , Horbinski Craig , Koochekpour Shahriar , Kyprianou Natasha
Published: April 2023

PDF file - 108KB, Evaluation of protein immunoreactivity in human prostate cancer tissue sections. Cofilin expression scoring scale from 0 (absence of immunostaining) to +3 (high expression). Magnification X100.
Supplementary Figure 3 from Fusobacterium in Colonic Flora and Molecular Features of Colorectal Carcinoma
Authors: Tahara Tomomitsu , Yamamoto Eiichiro , Suzuki Hiromu , Maruyama Reo , Chung Woonbok , Garriga Judith , Jelinek Jaroslav , Yamano Hiro-o , Sugai Tamotsu , An Byonggu , Shureiqi Imad , Toyota Minoru , Kondo Yutaka , Estécio Marcos R.H. , Issa Jean-Pierre J.
Published: April 2023

PDF file - 42K, Distribution of Fusobacterium in adjacent normal colonic mucosae in CRC patients (n=89).
Supplementary Figure 1 from Bioluminescent Imaging of HPV-Positive Oral Tumor Growth and Its Response to Image-Guided Radiotherapy
Authors: Zhong Rong , Pytynia Matt , Pelizzari Charles , Spiotto Michael
Published: April 2023

PDF file - 104KB, Orthogonal tumor dimensions a, b (blue line) and c are indicated. The oral tumor was assumed to be an ellipsoid shape. Based on the formula for an ellipsoid volume, we calculated the ellipsoid shape by: V = 4/3*p*a/2*b/2*c/2. To account for the oral aperture, we calculated this space according to a cylindrical shape having a radius equaling (a-d-e)/2 and height equaling c. The final tumor volume was calculated as the ellipsoid tumor less the oral aperture: V = (1/6*p*a*b*c) - p((1/2(a-d-e))2)*c.
Supplementary Figure Legends from Alarmin IL-33 Acts as an Immunoadjuvant to Enhance Antigen-Specific Tumor Immunity
Authors: Villarreal Daniel O. , Wise Megan C. , Walters Jewell N. , Reuschel Emma L. , Choi Min Joung , Obeng-Adjei Nyamekye , Yan Jian , Morrow Matthew P. , Weiner David B.
Published: April 2023

PDF file - 76KB
Supplementary Figure 2 from Alarmin IL-33 Acts as an Immunoadjuvant to Enhance Antigen-Specific Tumor Immunity
Authors: Villarreal Daniel O. , Wise Megan C. , Walters Jewell N. , Reuschel Emma L. , Choi Min Joung , Obeng-Adjei Nyamekye , Yan Jian , Morrow Matthew P. , Weiner David B.
Published: April 2023

PDF file - 58KB, IL-33 expands the frequency of the Ag-specific CD8+ T cells. P14 chimera mice (n=5) were vaccinated twice (on day 0 and day 41) containing GP33 with or without proIL-33. Displayed are representative fluorescent intensity plots of GP33/Ly5.1-specific CD8+ T cells responses in the blood of vaccinated mice at days 14, 21 and 31 after first vaccination and day 48 (day 7 after second immunization). Numbers indicate the percentage of Ag-specific CD8+ T Cells within the total CD8+ T cell populations. Experiments were performed independently at least two times and data are representative of the results.
Supplementary Figure 6 from EGF Receptor Activates MET through MAPK to Enhance Non–Small Cell Lung Carcinoma Invasion and Brain Metastasis
Authors: Breindel Jerrica L. , Haskins Jonathan W. , Cowell Elizabeth P. , Zhao Minghui , Nguyen Don X. , Stern David F.
Published: April 2023

PDF file - 2053K, MET knockdown and cell migration in PC9 and PC9-BrM3 cells.
Supplementary Video 1 from HuR Posttranscriptionally Regulates WEE1: Implications for the DNA Damage Response in Pancreatic Cancer Cells
Authors: Lal Shruti , Burkhart Richard A. , Beeharry Neil , Bhattacharjee Vikram , Londin Eric R. , Cozzitorto Joseph A. , Romeo Carmella , Jimbo Masaya , Norris Zoë A. , Yeo Charles J. , Sawicki Janet A. , Winter Jordan M. , Rigoutsos Isidore , Yen Timothy J. , Brody Jonathan R.
Published: April 2023

AVI file - 8883KB, siRNA Control cells progressing through mitosis after MMC treatment.
Supplementary Figure 5 from HuR Posttranscriptionally Regulates WEE1: Implications for the DNA Damage Response in Pancreatic Cancer Cells
Authors: Lal Shruti , Burkhart Richard A. , Beeharry Neil , Bhattacharjee Vikram , Londin Eric R. , Cozzitorto Joseph A. , Romeo Carmella , Jimbo Masaya , Norris Zoë A. , Yeo Charles J. , Sawicki Janet A. , Winter Jordan M. , Rigoutsos Isidore , Yen Timothy J. , Brody Jonathan R.
Published: April 2023

PDF file - 2070KB, WEE1 is post-transcriptionally regulated by HuR upon DNA damage.
Supplementary Table 2A from shRNA Kinome Screen Identifies TBK1 as a Therapeutic Target for HER2+ Breast Cancer
Authors: Deng Tao , Liu Jeff C. , Chung Philip E.D. , Uehling David , Aman Ahmed , Joseph Babu , Ketela Troy , Jiang Zhe , Schachter Nathan F. , Rottapel Robert , Egan Sean E. , Al-awar Rima , Moffat Jason , Zacksenhaus Eldad
Published: April 2023

PDF file - 44KB, Supplementary Table S2a and S2b list hits on Her2/Neu spheres and monolayer cells.
Supplementary Figure 3 from Increased Dietary Vitamin D Suppresses MAPK Signaling, Colitis, and Colon Cancer
Authors: Meeker Stacey , Seamons Audrey , Paik Jisun , Treuting Piper M. , Brabb Thea , Grady William M. , Maggio-Price Lillian
Published: April 2023

PDF file - 100K, Increased dietary vitamin D decreases inflammation in H. bilis-infected Smad3-/- mice.
Data Supplement from TLR7 Promotes Tumor Progression, Chemotherapy Resistance, and Poor Clinical Outcomes in Non–Small Cell Lung Cancer
Authors: Chatterjee Saradiya , Crozet Lucile , Damotte Diane , Iribarren Kristina , Schramm Catherine , Alifano Marco , Lupo Audrey , Cherfils-Vicini Julien , Goc Jeremy , Katsahian Sandrine , Younes Mohammad , Dieu-Nosjean Marie Caroline , Fridman Wolf Herman , Sautès-Fridman Catherine , Cremer Isabelle
Published: April 2023

Supplemental data. This supplemental data contains the supplemental figure legends and the supplemental tables 1 and 2 Supplemental table 1 describes the cohort of non treated NSCLC patients Supplemental table 2 describes the cohort of chemotherapy treated NSCLC patients