bluuebunny/crossref_metadata_2025 huggingface dataset:
The exploitation of climate chaos, confusion and change - a new frontier for P/CVE strategic communication
Authors: Wrigley Jodie
Published: June 2024

While scholarly debate continues about possible causal links between climate events and violent extremism, the evidence suggests that these events make communities more vulnerable to recruitment, provide fertile ground for anti-democracy sentiment, and erode trust in institutions and governments. It is recognised that many of these challenges play out in and leverage the on- and offline public sphere. Strategic communication, therefore, is an essential tool to utilise in this space to help prevent and counter violent extremism. This Policy Brief provides a starting point to explore further the potential nexus between climate events, violent extremism, and strategic communication. It explores a whole-of-society view of the potential strategic communication challenge and what actions practitioners could implement now to help address or minimise this existing or potential emerging threat.
EXAMINING THE IMPLICATION OF TQM, CUSTOMER SATISFACTION, SERVICE QUALITY, AND MARKET ORIENTATION IN PRIVATE BANK IN SURABAYA
Authors: Audrey Evelyn , Sutrisno Timotius F. C. W.
Published: June 2024

Total Quality Management (TQM) has gained significant attention across various industries as a concept to enhance organizational performance, including in banking industry. This research paper aims to investigate the implementation and impact of TQM principles in the banking industry, exploring its essential indicators including service quality, market orientation, and customer satisfaction. The study begins by reviewing the existing literature on TQM and its application in the banking industry, highlighting key concepts, methodologies, and discussion. Empirical data was taken from 185 bank workers in East Java Region of the Republic of Indonesia, especially Surabaya City. This study uses Confirmatory Factor Analysis to test construct reliability and validity, while the relationship between variables is examined with Partial Least Square/ PLS-SEM. This research uses purposive sampling, we are targeting private bank workers in Surabaya through online questionnaires spread by social media. This research contributes to the existing body of knowledge by providing a comprehensive review and analysis of TQM implementation in the banking industry. This research findings demonstrate that TQM has a significant relationship with Customer Satisfaction, Service Quality, and Market Orientation.

Abstrak dalam Bahasa Indonesia. Manajemen Mutu Total (TQM) telah mendapatkan perhatian signifikan di berbagai industri sebagai konsep untuk meningkatkan kinerja organisasi, termasuk dalam industri perbankan. Makalah penelitian ini bertujuan untuk menyelidiki implementasi dan dampak prinsip-prinsip TQM di industri perbankan, mengeksplorasi indikator-indikator pentingnya termasuk kualitas layanan, orientasi pasar, dan kepuasan pelanggan. Studi ini dimulai dengan meninjau literatur yang ada tentang TQM dan aplikasinya dalam industri perbankan, menyoroti konsep-konsep kunci, metodologi, dan diskusi. Data empiris diambil dari 185 pekerja bank di Wilayah Jawa Timur Republik Indonesia, khususnya Kota Surabaya. Penelitian ini menggunakan Analisis Faktor Konfirmatori untuk menguji reliabilitas dan validitas konstruk, sementara hubungan antar variabel diperiksa dengan Partial Least Square/PLS-SEM. Penelitian ini menggunakan purposive sampling, kami menargetkan pekerja bank swasta di Surabaya melalui kuesioner online yang disebar melalui media sosial. Penemuan penelitian ini berkontribusi pada tubuh pengetahuan yang ada dengan memberikan tinjauan dan analisis yang komprehensif tentang implementasi TQM di industri perbankan. Temuan penelitian ini menunjukkan bahwa TQM memiliki hubungan yang signifikan dengan Kepuasan Pelanggan, Kualitas Layanan, dan Orientasi Pasar.
MBAS AND ENTREPRENEURSHIP: A PERFECT PAIRING OR POTENTIAL MISMATCH?
Authors: Kleinova Ivona
Published: June 2024

The world economy has been experiencing and indeed appreciating the golden era of entrepreneurialism for quite some time now. The crucial element in this movement is entrepreneurs plentifully consuming accessible know-how and contemplating various funding options while benefiting from the digitised and globalised world. However, they often fail to succeed. In this paper, I assess the experience and knowledge of MBA graduate entrepreneurs on starting and running real businesses. I aim to explore what areas of new business development an MBA assists a nascent entrepreneur in launching a business. The research also intends to explore crucial MBA management tools and strategies vital in the start-up phase of a new business. To establish valid and robust empirical findings, I in-depth interviewed 10 MBA graduate entrepreneurs best acquainted with the research area. The study highlighted several areas within a new business formation where an MBA could assist a new entrepreneur and indicates as many as 26 MBA management tools and strategies that can be employed.

Abstrak dalam Bahasa Indonesia. Ekonomi dunia telah mengalami dan benar-benar menghargai era keemasan kewirausahaan untuk waktu yang cukup lama. Elemen krusial dalam gerakan ini adalah para pengusaha yang melimpah mengonsumsi pengetahuan yang mudah diakses dan mempertimbangkan berbagai pilihan pendanaan sambil memanfaatkan dunia yang terdigitalisasi dan terglobalisasi. Namun, mereka seringkali gagal untuk berhasil. Dalam makalah ini, saya menilai pengalaman dan pengetahuan para pengusaha lulusan MBA dalam memulai dan menjalankan bisnis nyata. Saya bertujuan untuk menjelajahi bidang-bidang pengembangan bisnis baru di mana seorang MBA membantu seorang pengusaha pemula dalam meluncurkan bisnis. Penelitian ini juga bermaksud untuk menjelajahi alat-alat manajemen dan strategi MBA yang penting dalam fase awal sebuah bisnis baru. Untuk mendapatkan temuan empiris yang valid dan kuat, saya melakukan wawancara mendalam dengan 10 pengusaha lulusan MBA yang paling akrab dengan area penelitian. Studi ini menyoroti beberapa area dalam pembentukan bisnis baru di mana seorang MBA dapat membantu seorang pengusaha baru dan menunjukkan sebanyak 26 alat manajemen dan strategi MBA yang dapat digunakan.
Health promotion and child obesity in the daily life of school children and families
Authors: Nabarro Marta , Nitschke Rosane Gonçalves , Tholl Adriana Dutra , Viegas Selma Maria da Fonseca , Bernardo Lucas Andreolli , Villa Sergio Eduardo Contreras
Published: June 2024

Objectives: to understand the daily life of families of boys and girls in pre-school and basic education in a school in the Barranco Amarillo sector, Magallanes and Chilean Antarctic Region; to know the experience of care related to the prevention of childhood obesity and the promotion of the health of their families. Method: qualitative, descriptive-exploratory study, based on the Comprehensive and Daily Sociology of Michel Maffesoli, with the participation of twelve families. Results: families have knowledge about good health, trying to eat healthy, but it is difficult for them to apply them because they do not find an appropriate routine, due to the higher cost of healthy foods, sedentary lifestyle, and the preference for fast foods, among others. Conclusion: it is necessary to establish intervention strategies in the prevention of childhood obesity, focusing on health promotion, for a dignified and healthy life.
Dificuldade na visibilidade e palpação da rede venosa periférica em adultos e idosos
Authors: DE AZEVEDO GUILHERME NASCIMENTO , Aparecida Trindade Monteiro Damiana , Alves dos Santos Lúbia , Aparecida Ferreira Lúcia , Machado Dutra Cíntia , Elaine Malaguti Toffano Silmara
Published: June 2024

Objetivo: Avaliar a dificuldade na visibilidade e palpação da rede venosa periférica em adultos e idosos admitidos em uma unidade de intervenção hemodinâmica. Método: Trata-se de um estudo observacional e prospectivo com abordagem quantitativa. Realizado com 105 participantes, dentre adultos e idosos, admitidos em unidade de intervenção hemodinâmica, em um hospital geral público e de ensino. Os dados foram coletados por meio de instrumento estruturado contendo variáveis demográficas e clínicas, com observação da punção intravenosa periférica. Realizou-se a análise descritiva, calculando as proporções. Resultados: A dificuldade durante a palpação e a visualização da veia foram de 11,4% e 16,2%, respectivamente. Entre os participantes que apresentaram dificuldade para visualização da veia, 60% tiveram insucesso na primeira tentativa de punção. Conclusão: A punção periférica em veias que possuem maior dificuldade para visibilidade e palpação contribuem para o insucesso na primeira tentativa.
The Influence of Government Expenditure on the Human Development Index in NTT Province
Authors: Banase Marianus Antonius Deo Datus , Purwono Rudi
Published: June 2024

Researchers analyzed government spending on health, education, and infrastructure in influencing the human development index in NTT Province. The research data is panel data in 22 districts/cities, namely health, education, and infrastructure expenditure data for 2010-2022. Panel data regression analysis used the pooled least square method to analyze government spending. The results found that government spending on health, education, and infrastructure together (simultaneously) significantly influenced the human development index in districts/cities in NTT province. Another analysis found that government spending on health and education partially influenced the human development index significantly in the districts/municipalities of the NTT province. However, spending on infrastructure partially had no significant effect on the human development index in the districts/municipalities of the NTT province. The implications of the research are improvements in health, education, and infrastructure that can increase development.
Synthesis and intracellular basic protein delivery of a polyanionic flexible organic framework
Authors: Liu Yue-Yang , Wu Yan , Guo Peng , Wang Hui , Zhou Wei , Zhang Dan-Wei , Li Zhan-Ting
Published: June 2024

Although cationic porous polymers have been widely used for gene and drug delivery, the delivering function of anionic porous polymers has rarely been explored. Herein, we prepare a polyanionic flexible organic framework (pa-FOF) through the quantitative formation of the acylhydrazone bond from a tetraanionic tetraaldehyde and a tetraanionic diacylhydrazine. Pa-FOF is highly water-soluble and has a size of 26 to 51 nm, which depends on the concentration of the monomers, and an aperture of approximately 3.8 nm. Fluorescence, zeta potential, confocal laser scanning microscopic and flow cytometric experiments reveal that pa-FOF can adsorb basic proteins, including lysozyme, trypsin and cytochrome c, which is driven by intermolecular ion-pairing electrostatic attraction and hydrophobicity, and realizes efficient intracellular delivery of the adsorbed proteins. Confocal laser scanning microscopic imaging experiments further illustrate that the delivery of cytochrome c can significantly increase its ability of causing cell apoptosis.
Development of a Canva-Based Toddler Nutrition E-Module in Applied Nutrition Courses
Authors: Zakiah Azzahra , Nur Riska  , Rusilanti
Published: June 2024

This research aims to: 1) Develop Canva-based toddler nutrition e-module teaching materials and 2) Assess the feasibility of Canva-based toddler nutrition e-module teaching materials. This teaching material was developed using the Research and Development method with the ADDIE development model. The stages of this research consist of five stages, namely analysis, design, development, implementation and evaluation. Research data was collected using a questionnaire and analyzed descriptively qualitatively. The results of the research show that Canva-based toddler nutrition e-module teaching materials are considered "Very Appropriate" by material experts with a percentage of 89%, by media experts with a percentage of 83% which is in the "Very Appropriate" category, and by language experts with a percentage of 100% which is falls into the "Very Decent" category. Product trials are carried out in three stages, namely one-on-one trials, small group trials and field trials. The results of the one-on-one trial assessment showed a feasibility level of 92% (very feasible), the results of the small group trial assessment were 85% (very feasible), and the results of the field trial assessment were 83% (very feasible).
Positional differences in match running performance of women soccer players
Authors: Kutnjak Manca , Bjelica Dusko , Modric Toni
Published: June 2024

This study aimed to identify positional differences in the running performance (RP) of professional women soccer players. Seventy match performances were observed during the official matches (n = 13) over the course of half of a season at the highest levelof national soccer competition in Slovenia. Players’ RP were obtained using global positioning system technology and were classified into five playing positions: central defender (CD; n = 11), fullback (FB; n = 15), central midfielder (CM; n = 9), winger (WM; n = 25) and forward (FW; n = 10). RP variables included total distance, high-intensity running, high-metabolic load distance, high-intensity accelerations and decelerations, and maximal running speed. Univariate and multivariate differences in RP among playing positions were analyzed by one-way analysis of variance and discriminate canonical analysis, respectively. Significant univariate differences were found for all RP variables (f = 3.77 –8.68, μ = 0.19 –0.33). Specifically, WMs, FBs, and CMs covered more total distance than CDs or FWs. High-intensity running, high metabolic load distance, high-intensity accelerations, and decelerations were greater for FBs or WMs compared to the players in all other playing positions. Analysis of multivariate differences showed significant differentiation between FBs and CMs, CDs, and FWs in high-intensity running distance, high-metabolic load distance, and high-intensity decelerations (CanR= 0.4 –0.77, all p < 0.01), respectively, with higher occurrence in FBs. These findings demonstrated the differing physical demands placed on national-level women's soccer players in different playing positions, offering valuable insights for their preparation
The UPDATE trial (UVB Phototherapy in Dermatology for ATopic Eczema): study protocol for a randomized controlled trial of narrowband UVB with optimal topical therapy versus optimal topical therapy in patients with atopic eczema
Authors: Knöps Eva , Spuls Phyllis Ira , Duijnhoven Ruben G , Dijkgraaf Marcel Gerrit Willem , Barreveld Marit van , Arents Bernd Wilhelm Menno , Enst Wynanda Annefloor van , Garritsen Floralie Maria , Merkus Maruschka Patricia , Middelkamp-Hup Maritza Albertina , Musters Annelie Hanna , Bosma Angela Leigh-Ann , Hyseni Ariënna Melissa , Dijkstra Jitske , Hijnen Dirk Jan , Gerbens Louise Anna Andrea
Published: June 2024

Background
Narrowband Ultraviolet B (NB-UVB) phototherapy is commonly prescribed for patients with moderate-to-severe atopic eczema (AE). The efficacy of NB-UVB, however, has not yet properly been established, as current evidence is of low certainty. Our aim is to assess the short-term and long-term (cost)effectiveness and safety of NB-UVB in adult AE patients by performing a pragmatic, multicenter, prospective, randomized, open-label, blinded-endpoint (PROBE) trial. This protocol outlines its methodology.
Methods
A pragmatic, multicenter, PROBE trial will be performed with 1:1 randomization of 316 adult patients with moderate-to-severe AE who have inadequate disease control with topical therapy and who are eligible for optimal topical therapy (OTT) or NB-UVB in combination with OTT as a next step. Participants in the interventional arm will receive a minimum of 3 months of OTT combined with 8 to 16 weeks of NB-UVB. The control group receives 3 months of OTT. Following the interventional phase, follow-up will continue for 9 months. Physician-reported and patient-reported outcomes (according to the Harmonising Outcome Measures for Eczema (HOME) Core Outcome Set) and adverse events are assessed at 4 weeks, 3, 6, 9 and 12 months.
Discussion
The UPDATE trial aims to provide high-quality evidence regarding the (cost-)effectiveness and safety of NB-UVB phototherapy in moderate-to-severe AE patients. Challenges that are addressed in the protocol include the possible bias arising from applying open label treatment, and the necessity of introducing OTT into the study design to prevent a high dropout rate.
Trial registration {2a} {2b}
ClinicalTrials.gov Identifier: NCT05704205, registered on December 8th 2022, https://clinicaltrials.gov/study/NCT05704205
Advancing Science and Economy in Space: An Empirical Assessment of the Experiments Conducted on the International Space Station National Laboratory
Authors: Wang Max
Published: June 2024

Expanding humanity beyond Earth entails scientific and socioeconomic advancements. Critical to this endeavor is to leverage space to improve terrestrial lives. Since its inception in 2005, the International Space Station United States National Laboratory has spearheaded in-space experimentation, transforming research into intellectual assets and applications on Earth. This paper evaluates the lab's scientific and economic impacts by linking ISS experimental records to scholarly publications and patent inventions. Our findings highlight several key points. First, the volume of experiments on the ISS has steadily increased, with notable contributions from commercial developers and investigators. Growth accelerated in 2012 following NASA's delegation of civilian research management to The Center for the Advancement of Science in Space. From the National Lab, 384 scholarly publications have emerged, predominantly post-2012 and from public sector investigations. However, this growth did not correspond to an increase in patent inventions. We then measured the impact of ISS research with paper and patent citations and applied regression analyses to estimate the variations associated with using the National Lab's facilities. Our results show that ISS papers and patents receive significantly higher citations than their terrestrial counterparts, even when individual scientist-level characteristics are fixed. The difference was disproportionately attributed to experiments developed by public entities, highlighting a fundamental distinction between private and public sciences. Overall, our findings suggest the gradual formation of an ecosystem around the ISS National Lab, which continuously advances scientific knowledge and economic development in space.
Effect of preoperative thoracic paravertebral nerve block using liposomal bupivacaine combined with drainage-tube patient-controlled analgesia on postoperative pain after thoracoscopic lobectomy: a prospective, multicentre, double-blind, randomized controlled study protocol
Authors: Sun Yongtao , Guo Na , Feng Yanyan , Zhang Min , Feng Hai , Sun Dongfeng , Li Yongmeng , Liu Mengjie , Guo Liang , Liu Kexuan , Zhu Ye , Ren Yiyan , Li Minghui , Chi Yongliang , Liu Zhongkai , Yuan Li , Lang Bao , Yang Zaiqi , Feng Nianhai , You Peijun , Zhang Wensheng , Su Diansan , Wu Jianbo
Published: June 2024

Backgroud: Thoracic paravertebral nerve block (TPVB) with liposomal bupivacaine (LB) is increasingly used for postoperative pain control in patients undergoing thoracic surgery, but relevant data are scarce, and there are few data on LB-TPVB combined with drainage tube patient-controlled analgesia (PCA). The aim of this study was to explore the effect of LB-TPVB combined with drainage-tube PCA on postoperative pain after thoracoscopic lobectomy.
Methods: This is a prospective, multicentre, double-blind, randomized controlled study. Participants will be randomly assigned to the standard bupivacaine (SB) group, SB + drainage-tube PCA (DTA) group, LB group, or LB + DTA group. The primary outcome is the 72-h mean numerical rating scale (NRS) pain score at rest. The target sample size is 228 patients, with 57 patients in each group.
Discussion: Our study hypothesizes that preoperative ultrasound-guided thoracic nerve block combined with drainage tube self-controlled analgesia is more effective in reducing postoperative pain following thoracoscopic lobe resection compared to thoracic nerve block alone. Additionally, liposomal bupivacaine was found to be more effective than standard bupivacaine in this context. These results will have implications for improving postoperative analgesia protocols for patients undergoing thoracoscopic lung surgery.
Trial registration: ClinicalTrials.gov, NCT06165991. Registered 29 November 2023, https://clinicaltrials.gov/study/NCT06165991.
Characterizing the tumor suppressor activity of FLCN in Birt-Hogg-Dubé syndrome through transcriptiomic and proteomic analysis
Authors: Tee Andrew , Jones Rachel-Ann , Dunlop Elaine A. , Champion Jesse , Doubleday Peter , Claessens Tijs , Jalali Zahra , Seifan Sara , Perry Iain , Giles Peter , Harrison Oliver , Coull Barry , Houweling Arjan , Pause Arnim , Ballif Bryan
Published: June 2024

Birt-Hogg-Dubé (BHD) syndrome patients are uniquely susceptible to all renal tumour subtypes. The underlying mechanism of carcinogenesis is unclear. To study cancer development in BHD, we used human proximal kidney (HK2) cells and found that long-term folliculin (FLCN) knockdown was required to increase their tumorigenic potential, forming larger spheroids in non-adherent conditions. Transcriptomic and proteomic analysis uncovered links between FLCN, cell cycle control and the DNA damage response (DDR) machinery. HK2 cells lacking FLCN had an altered transcriptome profile with cell cycle control gene enrichment. G1/S cell cycle checkpoint signaling was compromised with heightened protein levels of cyclin D1 (CCND1) and hyperphosphorylation of retinoblastoma 1 (RB1). A FLCN interactome screen uncovered FLCN binding to DNA-dependent protein kinase (DNA-PK). This novel interaction was reversed in an irradiation-responsive manner. Knockdown of FLCN in HK2 cells caused a marked elevation of γH2AX and RB1 phosphorylation. Both CCND1 and RB1 phosphorylation remained raised during DNA damage, showing an association with defective cell cycle control with FLCN knockdown. Furthermore, Flcn-knockdown C. elegans were defective in cell cycle arrest by DNA damage. This work implicates that long-term FLCN loss and associated cell cycle defects in BHD patients could contribute to their increased risk of cancer.
Clinical Value of 1-Hour Delayed Gadolinium-DTPA Enhanced 3D T1 SPACE MR Images in Bell's Palsy
Authors: Han Jingzhe , Zhang Jinru , Deng Jinliang , Hao Ziyan , Xie Yanan , Kang Zhilei , Ren Hao , Chong Lining
Published: June 2024

Background: This study aims to examine the clinical value of 1-hour delayed gadolinium-DTPA-enhanced3D T1 SPACE MRI in Bell's palsy.
Methods: Patients diagnosed with Bell’s palsy between January 2021 and January 2023 were retrospectively selected. Both routine and 1-hour delayed contrast-enhanced MRI were analyzed retrospectively. Signal intensity ratios of the facial nerve to that of the adenohypophysis were calculated.
Results: The affected side's signal intensity ratio was higher than the unaffected side in the labyrinthian and geniculate ganglion segments on both routine and 1-hour delayed contrast-enhanced MRI. Additionally, the signal intensity ratio of the affected side labyrinthian and geniculate ganglion segments in 1-hour delayed contrast-enhance MRI was higher than routine contrast-enhance MRI.
Conclusions: A contrast-enhance MRI of Bell’s palsy is functional for detecting inflammatory lesions. Delayed contrast-enhance MRI can indicate a higher distinction in the affected facial nerve.
Artificial intelligence algorithm for preoperative prediction of FIGO stage in ovarian cancer based on clinical features integrated 18F-FDG PET/CT metabolic and radiomics features
Authors: Xu Shilin , Zhu Chengguang , Wu Meixuan , Gu Sijia , Wu Yongsong , Cheng Shanshan , Wang Chao , Zhang Yue , Zhang Weixia , Shen Wei , Yang Jiani , Yang Xiaokang , Wang Yu
Published: June 2024

Purpose
The FIGO stage is critical to guiding the treatments of OC. We tried to develop a model to predict the FIGO stage of OC through machine learning algorithms with patients’ pretreatment clinical, PET/CT metabolic, and radiomics features. (2) Methods: We enrolled OC patients who underwent PET/CT scans and divided them into two cohorts according to their FIGO stage. Then we manually delineated the VOI and calculated PET metabolic features. Other radiomics PET/CT features were extracted by Python. We developed 11 prediction models to predict stages based on four groups of features and conducted three experiments to verify the meaning of PET/CT features. We also redesigned experiments to demonstrate the stage prediction performance in OCCC and MCOC. (3) Results: 183 OC patients were enrolled in this study, and we obtained 137 features from four groups of data. The best model was an adaptive ensemble with an AUC value of 0.819. Our proposed models presented the best result of 0.808 in terms of AUC in OCCC and MCOC patients’ groups. (4) Conclusion: Through AI algorithms, the PET/CT metabolic and radiomics features combined with clinical features could improve the accuracy of staging prediction.
FAM134B attenuates apoptosis and EMT by inhibiting M1 macrophage polarization via PI3K/AKT pathway in rat lungs exposed to hyperoxia
Authors: Guo Hong , Zhao Xin , Yao Ying , Yu Kaihua , Chen Su-Heng , Li Yu-Lan
Published: June 2024

Oxygen therapy is widely used in pulmonary disease and critical care resuscitation. Unfortunately, prolonged exposure to high concentrations of oxygen may cause oxygen toxicity, leading to hyperoxia-induced acute lung injury (HALI). The injurious effects of lung following hyperoxia exposure are well established, and the effects include cell apoptosis and epithelial-to-mesenchymal transition (EMT). HALI responds to the inflammatory response induced by M1 macrophage polarization. Suppressing inflammation in macrophages protects against HALI. The PI3K/AKT pathway promotes cell survival in oxidative stress injury. Activation of Akt is a beneficial response protects against hyperoxic stress. FAM134B activates ER-phagy through binding to LC3B, ER fragments are degraded by ER-phagy, and ER homeostasis is maintained. We hypothesized that FAM134B may regulate macrophage polarization and inflammatory responses in hyperoxia-exposed rats via PI3K/AKT signaling pathway, thereby attenuating HALI. In this study, we clarified the role of FAM134B in lung tissues of hyperoxia-exposed rats and the effect of FAM134B on macrophage polarization. The expression of FAM134B and PI3K/AKT pathway were inhibited in rat lung tissues after hyperoxia exposure. We found that overexpression of FAM134B activated the PI3K/AKT pathway and reduced apoptosis and EMT in rat lung tissues after hyperoxia exposure. The PI3K/AKT pathway inhibitor, LY294002, reversed the protective effect of FAM134B in hyperoxia-exposed rats. Overexpression of FAM134B reduced the release of inflammatory factors (IL-1β, TNF-ɑ, IL-6) and polarization of M1 macrophages after hyperoxia exposure, and LY294002 reversed this effect. In conclusion, our study showed that FAM134B inhibits M1 macrophage polarization and inflammatory factor release via PI3K/AKT pathway and attenuates apoptosis and EMT in rat lung of hyperoxia-exposed FAM134B is a key target for HALI, which provides new ideas for the treatment of HALI.
Priorities of Nano Geometries in Suspension
Authors: Ahmad Imtiaz , Khan Hidayat Ullah , Jan Rahim
Published: June 2024

The yield collective effect that is generated by each member of the LC phase largely depends on a uniform dispersion of nanoparticles. Evaporation techniques have been used to complete several fluidic-assisted designs. We examine isolated arrays of heterogeneous nanoparticles, taking into account the free entropic volume effect, comb- and brush-effect, electrostatic, and Van der Waals effects. The crystallographic facets of suspended particles and capping agents on their surfaces determine the optimal arrangement of shapes and orientations. It has been discovered that self-assembling activities occur prior to substrate deposition in nanoparticles with both flat and curved geometries. The drying capillaries drive the structures to develop into more aligned and tightly packed, making it easier to bring all of their shapes in suspension together due to dominant attractive interactions. We investigated some noteworthy cases that shed light on the quantitative and significant factors that are involved in constructing well-organized systems.
Study on the Influence of Water Mist on Methane Explosion Characteristic Parameters in Variable-volume Space
Authors: Xu Yang , Li Yuanbing , Li Mian , Duan Yulong
Published: June 2024

A transparent and variable volume pipe was used to investigate the influence of water mist on different development stages of methane explosion flame. A sliding device was installed to enable the adjustment of the pipe space volume during the experiments. The results demonstrate that water mist has varying effects on different flame development stages, leading to changes in flame development structure and mechanisms. When water mist is sprayed before the flame passes through the nozzle, it will cause a turbulent transformation of the flame, accelerate the flame propagation speed, and increase overpressure in the combustion zone. Specifically, when water mist acts on the tip of a finger flame, it promotes the explosion with a significant increase in overpressure and flame velocity, resulting in the maximum overpressure that is 90.48% higher compared to the without water mist condition. When the flame front has already passed through the nozzle and the water mist is sprayed, the water mist will significantly improve the efficiency of flame quenching and reduce the maximum overpressure in the unburned area. Compared with the absence of water mist, the overpressure in the unburned zone decreases by 21.91% and the flame extinction time decreases by 28.07%.
The Toxoplasma secreted effector TgWIP modulates dendritic cell motility by activating host tyrosine phosphatases Shp1 and Shp2
Authors: Morales Pavel , Brown Abbigale J. , Sangare Lamba Omar , Yang Sheng , Kuihon Simon , Chen Baoyu , Saeij Jeroen
Published: June 2024

The obligate intracellular parasite Toxoplasma gondii causes life-threatening toxoplasmosis to immunocompromised individuals. The pathogenesis of Toxoplasma relies on its swift dissemination to the central nervous system through a ‘Trojan Horse’ mechanism using infected leukocytes as carriers. Previous work found TgWIP, a protein secreted from Toxoplasma, played a role in altering the actin cytoskeleton and promoting cell migration in infected dendritic cells (DCs). However, the mechanism behind these changes was unknown. Here, we report that TgWIP harbors two SH2-binding motifs that interact with tyrosine phosphatases Shp1 and Shp2, leading to phosphatase activation. DCs infected with Toxoplasma exhibited hypermigration, accompanying enhanced F-actin stress fibers and increased membrane protrusions such as filopodia and pseudopodia. By contrast, these phenotypes were abrogated in DCs infected with Toxoplasma expressing a mutant TgWIP lacking the SH2-binding motifs. We further demonstrated that the Rho-associated kinase (Rock) is involved in the induction of these phenotypes, in a TgWIP-Shp1/2 dependent manner. Collectively, the data uncover a molecular mechanism by which TgWIP modulates the migration dynamics of infected DCs in vitro.
Dynamic monitoring of pulmonary endometriosis based on HRCT
Authors: Ni Yunlong , Feng Xia , Zhou Yingying
Published: June 2024

Endometriosis (EMS) refers to the appearance, growth and infiltration of endometrial tissues (glands and stroma) in the uterine cavity covering the endometrium and other parts of the uterus, repeated bleeding, Rare pelvic and intraperitoneal endometriosis can invade various areas such as the pleura, lungs, groin, umbilical cord, diaphragm, sciatic nerve, external ear, scalp, etc.Thoracic endometriosis syndrome (TES) is a rare disorder characterized.It can be divided into pleural and pulmonary endometriosis (PEM)according to the site of the lesion.The pathogenesis of TES has not yet been clarified, and multiple hypotheses have been proposed to explain its pathogenesis and clinical manifestations.The abnormality of the immune system is one of the important factors that cause and promote the occurrence and development of EMS.We report a 32-year-old woman diagnosed at our hospital with PEM presented a clinical characteristic of intermittent cough and hemoptysis and a pathologic manifestation of a large amount of hemosiderin deposition and a small amount of fibrous tissue.The patient was treated with leuprolide combined with tibolone. The patient’s cough and hemoptysis improved significantly within a short period of time, and his lung lesions improved significantly.At the same time,he did not develop serious related complications.Our report suggests that Add-back therapy of the patient’s conditions is necessary in PEM patients with not accepted surgical treatment.Leuprolide combined with tibolone may be an induction therapy with safety and feasibility.However, more clinical trials are needed to validate the efficacy and safety of the therapeutic regimen.
Heading biomechanics in female football: A systematic scoping review
Authors: Cicchella Antonio , Liu QIngguang , Chen Shinting , Shen Yinhao
Published: June 2024

Heading is a key skill in soccer. Research on heading focused mostly on males and young players, but it has been rarely investigated in female soccer players. Play scenario, training level, anthropometrics, frequency and intensity of headings, and long-term outcomes, such as vigilance and neuro-cognitive condition, are of interest for injury prevention. This systematic review aims to survey available knowledge about heading biomechanics in female football players to identify possible weakness and issues for future research directions in the field. A structured literature search was performed in PubMed, Scopus, Web of Science, and Sport Discus. The selection criteria included the following: (i) studies that focused on head impact only in females in soccer; and (ii) studies that included mechanics of the heading in females and outcomes (acute or long terms). Research on heading in female soccer players is sparse, and drawing firm conclusion on the investigated aspects (effect of play position, occurence, cognitive impairment, influence of muscle strength, and player’s level) is difficult. Mild-intensity heading is not dangerous, helmet does not help, play state and player position influence heading, and high rotational velocities are achieved. Response to a long kick is more risky, and strenghtening of neck muscles helps prevent injuries. This work identifies new direction for research and a basis on ameliorating heading training and skills and developing an effective and safe heading technique. Initiatives to improve safety in women’s soccer and prevent injuries from heading are necessary to reduce the gap in the knowledge between men and women players.
Impact of Seeds Germination on the Physicochemical and Techno-Functional Properties of Lupin Flours and Isolates
Authors: Navarro-Vozmediano Paola , Bou Ricard , García-Pérez José V. , Dalmau Esperanza , Benedito José J.
Published: June 2024

Nowadays, lupin seeds have emerged as a novel and valuable source of proteins representing a sustainable alternative to current raw materials of plant-based proteins, such as soybean. In this regard, lupin demonstrates superior adaptation to the Mediterranean climate with improved tolerance to water stress. However, its suitability for human consumption is limited due to the presence of anti-nutritional and anti-technological factors, including alkaloids, polyphenols, tannins and lipids, which can have adverse nutritional consequences and/or impact on the purity and yield of protein extraction. In this study, the Lupinus luteus seeds were germinated for 1, 2, 3 and 6 d and the effect of germination on the anti-nutritional and anti-technological factors of flours and derived protein isolates was analyzed. Additionally, changes on techno-functional properties of lupin protein isolates were also studied. Results showed that prolonged germination decreased fat content whereas antioxidant activity, polyphenols, saponin, and alkaloid content of flours increased. However, alkaloids were completely removed during protein extraction. Furthermore, protein isolates derived from germinated seeds exhibited higher water and oil absorption capacities, as well as an improved foaming and emulsifying capabilities in comparison to isolates from non-germinated seeds. Nevertheless, prolonged germination periods were associated with diminished foam and emulsion stability. Therefore, germination of lupin seeds for no longer than 3 d should be recommended in order to minimize the levels of anti-nutritional and anti-technological factors, while enhancing techno-functional properties of the isolate.
Universal Full-Day Kindergarten and Maternal Labor Supply: A Life-Cycle Analysis
Authors: Erceg Ashley , Genadek Katie , West Kristine
Published: June 2024

We estimate the effect of state-level policies enacting universal free full-day kindergarten on mothers’ labor supply using a life-cycle analysis. Similar to previous research on childcare and labor supply, we find that free full-day kindergarten increases labor force participation rates for mothers whose youngest child is kindergarten-aged by 4.3 to 7.1 percentage points. We find that for mothers whose youngest child is an infant, labor force participation increases by 7.2 to 9.8 percentage points, and for women whose youngest child is 3 to 4 years old labor force participation increases by 5.9 to 7.9 percentage points. The fact that the policies impact the labor supply for mothers of younger-than-kindergarten-age children by even more than for mothers of kindergarten-aged children is important for understanding the full effect of subsidized childcare. This is consistent with a life-cycle model of labor supply where wages and prices in future periods impact mothers’ labor force attachment.
Assessing the Microbiological Spectrum of Dacryocystitis Patients at a Tertiary Eye Hospital: A Retrospective Study
Authors: Alshehri Amjad , Alwazae Manal , AlAbdulakadir Ghaliah , Altahan Faisal , AlThaqib Abdulrahman , Alsuliman Hamad , AlThaqib Rawan
Published: June 2024

Purpose: The purpose of this study is to determine the microbiological spectrum and the demographics of dacryocystitis patients.
Methods: A retrospective chart review on patients’ electronic medical records were utilized to collect data on patients who presented with dacryocystitis. A total of 97 patients were included and data were collected on the demographics, type of organisms, antibiotic sensitivity, response to antibiotics therapy, management, and complications.
Results: Gram-positive cultures predominated in all genders in both adult and pediatric age groups and accounted for 61.3% of the sample. In adults, Staphylococcus aureus was the leading gram-positive organism (25.7%) while Pseudomonas aeruginosa(7.9%) and Haemophilus influenzae (6.9%) were the most common gram-negative organisms. In pediatric cases, Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes, and Streptococcus intermedius were equally prevalent and gram-negative infection was exclusively due to Haemophilus species (26%).
Conclusions: Comprehending the microbiologic spectrum and its trend is crucial for managing an infection and recommending suitable antibiotic therapy. Initial Empirical therapy for dacryocystitis cases is targeted toward the Gram-positive organisms due to its prevalence. As a result, we heartily advise conducting a local study from time to time to assess the trend in the microbiological spectrum and shift in epidemiology, along with the antimicrobial sensitivity.
Nile tilapia nursery in different rearing systems during autumn in a subtropical region
Authors: SILVA Bruno Corrêa , MASSAGO Haluko , CANDIA Efrayn Wilker Souza , VIEIRA Felipe do Nascimento , JATOBÁ Adolfo , SERAFINI Raphael de Leão
Published: June 2024

The nursery phase in autumn is an important strategy for scaling up tilapia farming in subtropical regions, which otherwise suffers from a lack of fingerlings in winter. Tilapia nursery is carried out in a semi-intensive system in ponds; however, the biofloc technology system (BFT) has productive, environmental and health advantages. This study aimed to compare the production of Nile tilapia (Oreochromis niloticus) juveniles in two rearing systems during autumn through the evaluation of zootechnical, environmental, and hematological parameters, as well as production costs. In each system, four experimental units were used on a pilot scale and stocked with fingerlings with an average weight of 1.95 ± 0.32g. In the semi-intensive system, 25 m³ ponds were used, and each was stocked with 1,100 fingerlings (44 fish.m− 3). In the super-intensive system, 4 m³ circular tanks were used, each stocked with 2,200 fingerlings (550 fish.m− 3). The production of tilapia juveniles in BFT showed greater stability of water quality parameters throughout rearing in association with higher water temperature owing to the greenhouse. This allowed similar growth between fish in both systems, but with productivity 12.7x higher in BFT, while consuming 29.6x less water. Hematological parameters among fish in the two systems were also similar. Finally, BFT showed a lower total operating cost.
Development of a tunable infrared pyroelectric element based on the interferometer principle
Authors: Wang Boqiang , Zhao Xuezeng , Zhang Yiyong , Song Zigang , Wang Zhuogang
Published: June 2024

To realize the detection of multiple hydrocarbon combustible gases by non-dispersive infrared gas concentration sensors (NDIR), a tunable infrared pyroelectric sensitive element needs to be developed. This paper is based on the principle of the interferometer, which adopts a T-type over-damped spring suspension to fix the two reflectors, and utilizes electrostatic force to control the distance between the two reflectors to achieve the adjustment of the central wavelength of the infrared pyroelectric sensitive element. The developed tunable infrared pyroelectric sensitive element has a center wavelength adjustment range of 3000-3481nm, a stable adjustment time of less than 55ms, a temperature fluctuation of less than 4nm/K, and an imprecise spectral scanning in the range of 3000-4000nm. This type of component has fast, low-temperature drift and a wide range of center wavelength adjustment functions, as well as non-precise spectral scanning functions. It provides reliable support for the detection of different types of hydrocarbon combustible gases by the same NDIR sensor.
Oxidative and Excitatory Neurotoxic Stresses in CRISPR/Cas9-Induced Kynurenine Aminotransferase Knock-out Mice: A Novel Model for Experience-Based Depression and Post-Traumatic Stress Disorder
Authors: Szabó Ágnes , Galla Zsolt , Spekker Eleonóra , Szűcs Mónika , Martos Diána , Takeda Keiko , Ozaki Kinuyo , Inoue Hiromi , Yamamoto Sayo , Toldi József , Ono Etsuro , Vécsei László , Tanaka Masaru
Published: June 2024

Background: Memory and emotion are highly vulnerable to psychiatric disorders like post-traumatic stress disorder (PTSD), which has been linked to serotonin (5-HT) metabolism disruptions. In fact, over 90% of the 5-HT precursor tryptophan (Trp) is metabolized via the Trp-kynurenine (KYN) metabolic pathway, producing a variety of bioactive molecules. The aadat (kat2) gene encodes mitochondrial kynurenine aminotransferase (KAT) isotype 2, responsible for kynurenic acid (KYNA) production. Little is known about its role in behavior.
Methods: In CRISPR/Cas9-induced aadat knockout (kat2−/−) mice, we examined the effects on emotion, memory, motor function, Trp and its metabolite levels, enzyme activities in the plasma and the urine of 8-week-old males compared to wild-type mice.
Results: Transgenic mice showed more depressive-like behaviors in the forced swim test, but not in the tail suspension, anxiety, or memory tests. They also had fewer center field and corner entries, shorter walking distances, and fewer jumping counts in the open field test. Plasma metabolite levels are generally consistent with those of urine: KYN, antioxidant KYNs, 5-hydroxyindolacetic acid, and indole-3-acetic acid levels are lower; enzyme activities in KATs, kynureninase, and monoamine oxidase/aldehyde dehydrogenase are lower, but kynurenine 3-monooxygenase is higher; and oxidative stress and excitotoxicity indices are higher.
Conclusion: Transgenic mice show depression-like behavior in a learned helplessness model, emotional indifference, and motor deficits, coupled with a decrease in KYNA, a shift of Trp metabolism toward the KYN-3-HK pathway, and a partial decrease in the gut microbial Trp-indole pathway metabolite. This is the first evidence that deleting the aadat gene causes depression-like behaviors that are unique to despair experience, which appears to be linked to excitatory neurotoxic and oxidative stresses. This may lead to the development of a double-hit preclinical model in experience-based depression, better understanding of these complex conditions, and more effective therapeutic strategies by elucidating the relationship between Trp metabolism and PTSD pathogenesis.
Predicting Landslides with Machine Learning: A Data-Driven Approach
Authors: Sarawagi Karan , Singh Navjot , Virdi Khushwant
Published: June 2024

Landslides are natural disasters that can cause significant damage to the environment and pose a serious threat to human lives and infrastructure. Early detection and identification of potential landslide-prone areas are crucial for disaster mitigation and preparedness efforts. This abstract out- lines a comprehensive approach to landslide identification uti- lizing machine learning techniques. In recent years, machine learning has emerged as a powerful tool for analyzing geospatial data and predicting geological hazards such as landslides. This research leverages a diverse range of data sources, including remote sensing imagery, topographical maps, rainfall records, and geological data, to develop a robust landslide identification model. The key components of the proposed methodology involve data preprocessing, feature engineering, and the application of various machine learning algorithms. Remote sensing data, such as satellite imagery and LiDAR data, are used to extract valuable terrain features and land cover information. Rainfall data are incorporated to assess the influence of precipitation on landslide occurrence. Geological data contribute to the understanding of local geological conditions. Several machine learning algorithms, including but not limited to decision trees, support vector machines, and neural networks, are employed to create predictive models. These models are trained on historical landslide data and validated against real-world cases. Cross-validation techniques are applied to ensure the model’s robustness and generalization capabilities.