bluuebunny/crossref_metadata_2025 huggingface dataset:
Advancements in Hepatocellular Carcinoma: Potential Preclinical Drugs and their Future
Authors: Baytas Sultan Nacak , Butt Noor-ul-Huda
Published: December 2022

Hepatocellular carcinoma (HCC) is one of the foremost causes of tumor-affiliated demises globally.
The HCC treatment has undergone numerous developments in terms of both drug and non-drug treatments. The
United States Food and Drug Administration (FDA) has authorized the usage of a variety of drugs for the treatment
of HCC in recent years, involving multi-kinase inhibitors (lenvatinib, regorafenib, ramucirumab, and
cabozantinib), immune checkpoint inhibitors (ICIs) (pembrolizumab and nivolumab), and combination therapies
like atezolizumab along with bevacizumab. There are currently over a thousand ongoing clinical and preclinical
studies for novel HCC drugs, which portrays a competent setting in the field. This review discusses the
i. FDA-approved HCC drugs, their molecular targets, safety profiles, and potential disadvantages; ii. The intrial
agents/drugs, their molecular targets, and possible benefits compared to alternatives, and iii. The current
and future status of potential preclinical drugs with novel therapeutic targets for HCC. Consequently, existing
drug treatments and novel strategies with their balanced consumption could ensure a promising future for a universal
remedy of HCC in the near future.
Systematic literature review on the utilization of theoretical underpinnings in virtual exchange research
Authors: Dovrat Liz
Published: December 2022

Virtual Exchange (VE) research is a subset of the technology enhanced learning field that has grown exponentially in the last decade. A critical step in the growth of an emerging academic field is to reflect on past research to understand what has been done well and what can be improved. This Systematic Literature Review (SLR) contributes to this reflective process by examining if a common criticism of technology enhanced learning research in Higher Education (HE) – the under-utilization of theoretical underpinnings in research – extends to the niche field of VE research. Using a qualitative meta-synthesis methodology, 42 qualitative and mixed method articles on VE were analyzed for theoretical underpinning usage, application, and advancement. Almost half of the articles explicitly used theoretical underpinnings in the conceptualization, data collection and analysis, and discussion of results. About a third of the articles explicitly used theoretical underpinnings in the design of the VE, but not necessarily in the research design. No articles reported adding to or advancing current theoretical underpinnings nor creating new ones. The results of this study show VE research is maturing but is not yet fully mature in the application of theoretical underpinnings in research. Also, this study contributes to analysis of theoretical underpinning usage by demonstrating that theoretical underpinnings are utilized also in course design, not just research design.
Максимальная прыжковая электропроводность на постоянном токе по водородоподобным примесям в полупроводниках
Authors: Поклонский Н.А. , Вырко С.А. , Аникеев И.И. , Забродский А.Г.
Published: December 2022

A quasi-classical model for calculating DC (direct current) electrical conductivity in crystalline semiconductors with hydrogen-like impurities is developed at the transition from band conduction to impurity hopping conduction with decreasing temperature. This transition from the minimum band conductivity to the maximum hopping conductivity via impurities has the form of a characteristic ``kink'' in the temperature dependence of the electrical resistivity. The idea of the calculation is to preliminarily determine the transition temperature Tj using the standard approach within the framework of the two-band model. The shift of the top of the v-band (the bottom of the c-band) into the depth of the band gap due to the formation of a quasi-continuous band of allowed energy values from the excited states of acceptors (donors) is taken into account. This leads to a decrease in the value of a thermal ionization energy of the main shallow impurities due to a decrease in the maximum localization radius of a hole on an acceptor (an electron on a donor) with increasing impurity concentration. The values of the observed maximum hopping conductivity and drift hopping mobility corresponding to the temperature Tj are calculated. The numerical calculation within the framework of the proposed model is consistent with the known experimental data on the electrical conductivity and Hall coefficient of moderately compensated p-Ge crystals doped by neutron transmutation and non-intentionally compensated metallurgically doped n-Ge, as well as n- and p-Si crystals on the insulator side of the Mott insulator–metal concentration phase transition.
Эффект компенсации роста времени жизни носителей заряда в полупроводниках в магнитном поле
Authors: Муратов Т.Т.
Published: December 2022

The condition of regulation of increasing of carrier lifetime by recombination processes in semiconductors at low temperatures (1-10) K and classical "strong" magnetic fields (300-30000) Gs are analyzed. The values of carrier concentrations (10^10-10^14) cm^-3 correspond to conditions of manifestation as cascade as resonant capture. It is indicated on necessarily to take into account of scattering of electrons on acoustic phonons along with electron-electron collisions, by it cascade capture on cuolomb centers. As showed (on the basis of concrete estimates) namely scattering on acoustic phonons at cascade capture, stabilities of lifetime and controls of dynamics it increases in the presence of "strong" magnetic field.
Оптические свойства нановискеров Cu-=SUB=-2-=/SUB=-O
Authors: Лабзовская М.Э. , Новиков Б.В. , Серов А.Ю. , Микушев С.В. , Давыдов В.Ю. , Смирнов А.Н. , Талалаев В.Г.
Published: December 2022

The optical properties of Cu2O nanowhiskers grown by the liquid method with material deposition in an electric field have been studied. The spectral lines forbidden by the selection rules for perfect Cu2O crystals were found in the Raman spectra. The nature of related phonon states is analyzed. In the photoluminescence spectra in the red and near-IR regions, broad bands of defective origin are observed. It was found that the presence of a band at 650 nm (1.9 eV) is a specific feature of
the photoluminescence of nanowhiskers. Its properties are studied and possible radiation mechanisms are discussed. In the intrinsic absorption region of nanowhiskers, the photoluminescence band at 572 nm (2.17 eV) associated with band−band transitions is detected. At a low excitation level, the emission of a free exciton n = 1 of the yellow exciton series is observed with simultaneous emission of an optical phonon.
Динамика предельно коротких импульсов в примесных двухуровневых системах в рамках подхода Глаубера-=SUP=-1-=/SUP=-
Authors: Белоненко М.Б. , Конобеева Н.Н.
Published: December 2022

In this work, we study the features of the propagation of extremely short optical pulses in a two-level system using the example of a deuterated ferroelectric containing carbon nanotubes. Based on the Heisenberg equation of motion for the average values of the pseudospin operators, as well as the wave equation for the electric field, a numerical simulation of the dynamics of an electromagnetic pulse is carried out. The evolution of the system for various parameters of the problem is demonstrated.
Исследование поверхностного слоя, образующегося при обработке кварцевого стекла с помощью механохимического и ионного полирования
Authors: Золотарев В.М.
Published: December 2022

Проведены количественные исследования оптических параметров поверхностного слоя, образующегося в процессе полирования кварцевого стекла. Показано, что механизм формирования поверхностного слоя при использовании методов механо-химической и ионной полировки имеет много общего. В обоих случаях появление поверхностного слоя, отличающегося высоким показателем преломления от соответствующих объемных свойств стекла, связано с напряжением и разрывом мостиковых связей Si-O-Si в процессе гидролиза при полировке стекла. Гидролиз связей Si-O-Si связан с образованием групп Si-O и Si-OН, что приводит к увеличению показателя преломления поверхностного слоя. Ключенвые слова:
Измерение показателя преломления с помощью гониометрической системы
Authors: Юрин А.И. , Вишняков Г.Н. , Минаев В.Л.
Published: December 2022

The article proposes a method for measuring the refractive index using a goniometric system that does not require measuring the prism angle, which simplifies the measurement process compared to the widely used methods of minimum deviation and autocollimation. This method can be used to measure the refractive index of samples in the form of triangular prisms in the visible, ultraviolet and infrared ranges. To implement the method, a goniometric system was used. To obtain the reflection of the refracted beam, a fixed mirror was used, and the refractive index of the prism material was calculated from the solution of a system of equations. The results of an experimental study of a triangular prism made of optical glass N-BK7 using the proposed method and their comparison with the data obtained on the State Primary Standard of the Refractive Index Unit GET 138-2021 are presented.
Электронный спиновый резонанс NV-=SUP=-(-)-=/SUP=--центров в микрокристаллах синтетического флуоресцентного алмаза в условиях оптической спиновой поляризации
Authors: Осипов В.Ю. , Богданов К.В. , Rampersaud A. , Takai К. , Ishiguro Y. , Баранов А.В.
Published: December 2022

Electron paramagnetic resonance (EPR) spectra of synthetic diamond microcrystals with NV(-) centers have been studied. It is shown that under the conditions of irradiation of the material with the light of a xenon lamp at low temperatures ~100 K, the intensities of the EPR signals corresponding to the “forbidden” (dms=2) and low-field allowed (dms=1) transitions are amplified several times, while the EPR signals from paramagnetic nitrogen and impurity nickel in the charge state -1 practically do not change. This is due to a change in the population of levels of the ground triplet state of the NV(-) center and the optical polarization of spins in the state ms=0 of the triplet level.
Personalized Help-Seeking Web Application for Chinese-Speaking International University Students: Development and Usability Study
Authors: Choi Isabella , Mestroni Gemma , Hunt Caroline , Glozier Nick
Published: December 2022

Background

The mental health of international students is a growing concern for education providers, students, and their families. Chinese international students have low rates of help seeking owing to language, stigma, and mental health literacy barriers. Web-based help-seeking interventions may improve the rate of help seeking among Chinese international students.

Objective

This study aimed to describe the development of a mental well-being web app providing personalized feedback and tailored psychoeducation and resources to support help seeking among international university students whose first language is Chinese and test the web application’s uptake and engagement.

Methods

The bilingual MindYourHead web application contains 6 in-app assessments for various areas of mental health, and users are provided with personalized feedback on symptom severity, psychoeducation tailored to the person’s symptoms and information about relevant interventions, and tailored links to external resources and mental health services. A feasibility study was conducted within a school at the University of Sydney to examine the uptake and engagement of the web application among Chinese international students and any demographic characteristics or help-seeking attitudes or intentions that were associated with its engagement.

Results

A total of 130 Chinese international students signed up on the web application. There was an uptake of 13.4% (122/908) in the schools’ Chinese student enrollment. Most participants (76/130, 58.5%) preferred to use the web application in Chinese and used informal but not formal help for their mental health. There was considerable attrition owing to a design issue, and only 46 students gained access to the full content of the web application. Of these, 67% (31/46) of participants completed 1 or more of the in-app mental well-being assessments. The most commonly engaged in-app assessments were distress (23/31, 74%), stress (17/31, 55%), and sleep (15/31, 48%), with the majority scoring within the moderate- or high-risk level of the score range. In total, 10% (9/81) of the completed in-app assessments led to clicks to external resources or services. No demographic or help-seeking intentions or attitudes were associated with web-application engagement.

Conclusions

There were promising levels of demand, uptake, and engagement with the MindYourHead web application. The web application appears to attract students who wished to access mental health information in their native language, those who had poor mental health in the past but relied on informal support, and those who were at moderate or high risk of poor mental well-being. Further research is required to explore ways to improve uptake and engagement and to test the efficacy of the web application on Chinese international students’ mental health literacy, stigma, and help seeking.
The Current Knowledge, Attitudes, and Practices of the Neglected Methodology of Web-Based Questionnaires Among Chinese Health Workers: Web-Based Questionnaire Study
Authors: Fang Heping , Lv Yuxin , Chen Lin , Zhang Xuan , Hu Yan
Published: December 2022

Background

Web-based questionnaire (WBQ) surveys are popular, but the quality of reporting WBQ survey research is uneven and unsatisfactory worldwide. Education and training on WBQ methodology may be necessary. However, the current knowledge, attitudes, and practices (KAP) of its methodology remain unknown.

Objective

We investigated the KAP of WBQ methodology among Chinese health workers for the first time to clarify the possible reasons for the unsatisfactory reporting quality of WBQ survey research from China’s experience, aiming to provide a basis for improvement.

Methods

We developed a structured WBQ based on the current recommendations and knowledge and investigated 458 health workers from June 7 to July 6, 2022. A total of 381 valid questionnaires were analyzed after data processing. We defined 50% and 75% as “qualified” and “satisfactory” in knowledge and practice topics to describe the results and analyzed the basic characteristics of the participants who had difficulties in conducting WBQ survey research.

Results

A total of 215 (56.4%) participants had used WBQs for investigation, mostly more than 2 times (88.3%), but only 95 (44.2%) of them had ever received methodological training. A total of 134 (62.3%) users believed that WBQs were practical, but 126 (58.6%) had doubts about the reliability of the results. Most of the knowledge and practice topics did not reach a satisfactory level, and some even did not reach a qualified level. A total of 95 (44.2%)-136 (63.3%) of the users had reported difficulties in conducting WBQ survey research, and different participants could have different difficulties according to their characteristics. In addition, 191 (88.8%) users believed training was necessary.

Conclusions

We found that Chinese health workers seriously underestimated and neglected the importance of the WBQ methodology, which may be an important reason for the reduced reporting quality of WBQ survey research. Medical educators need to strengthen methodological training on WBQs, which may help to improve the quality of WBQ survey research.
Evaluating the frequency of false-positive detection in electrocardiogram devices in comparison to cardiologist diagnosis: instrument validation study (Preprint)
Authors: Chandola 4th nitin , Singh Sr Yogendra , Mahajan 2nd Sahil , Bhatia 5th Tanuj , Sharama 6th Richa , Garg 3rd Salil , Bansal Jr Basundhara
Published: December 2022

BACKGROUND

Electrocardiography is the most convenient and cost-effective method at the primary level of healthcare infrastructure to localize and diagnose Myocardial infarction, ischemic heart diseases, and numerous arrhythmias. The manufacturers of ECG machines provide computer-generated Interpretations. However, these machines have differences in implementing the algorithms, which causes a change in diagnostic accuracy. Hence, the occurrence of False positives is the most commonly observed error that occurs during computer interpretation.

OBJECTIVE

This study aims to evaluate the differences observed in the computerized interpretation of ECG reports regarding the Cardiologist's diagnosis.

METHODS

The 12-lead ECG reports were collected from a 12-lead gold standard machine and a smartphone-based 12 lead ECG machine. The data of the 294 subjects out of 300 subjects were accessed from both ECG machines. The reports were evaluated by a Cardiologist based on the observational changes in the morphology of the ECG traces.

RESULTS

The gold standard ECG machine was 92% sensitive, 47.9% specific and 26.43% accurate in correctly interpreting a normal ECG report concerning the diagnosis provided by a Cardiologist. Whereas the Smartphone-based 12 lead ECG was found to be 95.9% sensitive, 88.9% specific, and 86.2% accurate in detecting a normal ECG concerning the diagnosis provided by a Cardiologist.

CONCLUSIONS

The ECG machine manufacturer's interpretation algorithm plays an important role in defining the accuracy of the ECG machine. Computerized interpretation is only an assisting tool for clinicians and not an independent tool to be relied on while treating a patient during health emergencies and check-ups.
The Potential Secondary Metabolites of Macroalgae Sargassum polycystum C. Agardh (1824) from the coast of West Aceh as Raw Material of Body Scrub
Authors: Gazali Mohamad , Nurjanah Nurjanah , Husni Amir , Nufus Chairun , Aulia Bintan Rahma , Febrina Citra Dina , Syafitri Rina
Published: December 2022

Sargassum polycystum is one brown seaweed with a rich alginate source. The previous study showed that S. polycystum could be used as a cosmeceutical raw material because of its natural attribute and safe. S. polycystum always grows in many coastal of Indonesia. This study aims to characterise brown seaweed (S. polycystum) as the raw material of the body scrub. The research method includes the extraction, phytochemical assay, antioxidant assay, and total phenolic content-the phytochemical screening-detected alkaloid and steroid compounds in S. polycystum extract. The antioxidant activity by using the CUPRAC method showed the ethanol extract was 53.55±1.07 µM/g and FRAP was 201.95±6.33 µM/g with total phenolic content was 177.647±21.39 Mg GAE/g. We compared the antioxidant capacity of the body scrub by adding brown seaweed of S. polycystum 7% (S7) used the CUPRAC method was 34.23±0.33 µM/g, and FRAP was 124.05±1.87 µM/g with total phenolic content was 416.31±78.44 Mg GAE/g. Kruskal Wallis's analysis showed that adding brown seaweed S. polycystum with different formulas influenced the panellist's preference for smearing ability, odor, texture, colour, and consistency parameters. According to the Mean rank obtained, the level of preferences of the panellists was gained from product S7 namely body scrub with the addition of brown seaweed S. polycystum as much as 7%. It is indicated that the brown seaweed S. polycystum possesses potentially body scrub raw material that is prospective in the cosmeceutical industry.
The Ratio of Storage Volume to Cubic Number for Rampus Nets at The Karangantu Archipelago Fishery Port-Banten
Authors: Ramadhanti Annisa , Novita Yopi , Imron Mohammad , Bangun Tri Nanda Citra , Iskandar Budhi Hascaryo
Published: December 2022

The Banten Province Maritime Affairs and Fisheries Service plans to standardize the hold volume for fishing vessels in its management area. The management plan is still challenging to implement because there is no information about the vessel storage volume. In addition, small fishing vessel fishers still store their catch in boxes made of fibre-reinforced plastic (FRP). That box is often placed on the deck floor, causing decreased vessel stability. The size of the available storage volume on the vessel must be ideal, so it needs to be compared with the cubic number. This research aims to determine the optimal storage volume to cubic number ratio for rampus net vessels with the best stability conditions. The sampling technique used was accidental sampling with a total sample of 10% from 72 fishing vessels. Data processing used mathematical calculations and stability simulation with the GZ program. Analysis of the data used is descriptive analysis. The results showed that the optimal ratio of storage volume to cubic number for vessels with sizes 3-5 GT ranged from 5.03 - 8.55%. That ratio was a storage condition designed inside the hull construction, and the catch is directly put into the store without using the FRP box. From the stability point of view, condition 3 is the best for the quality of fishing vessel’s stability. This due to the lowest value of KG in condition 3 comparing to other conditions.
Effect of Peat Water Mix with Borehole Water on Mortality of African Catfish
Authors: Ardianor Ardianor , Handayani Tutwuri , Yusuf Noor Syarifuddin , Elvince Rosana
Published: December 2022

Generally, cultured fish are suitable in media with a pH of around 7, like mountainous river and borehole water.  However, peat water is known with low pH.  It is not suitable for fish culture, especially for fingerlings.  This study was conducted to examine the survival of African catfish fingerling (Clarias gariepinus) in the mixture of peat and borehole water with different pHs. Survival test of African catfish as subject applied bioassay method, LC50-96 hours.  Peat water as the agent was arranged for 11 concentration levels of 0% - 100% with no replication and placed in plastic basins with 20 liters each. Catfish fingerlings were used for subject fish (size 10-15 cm) and 10 individuals in each basin. Water quality, mortality, and behavior of fish were observed. Results showed that the survival ability of African catfish on peat water, the LC50-96 hours was 63.8%, with 95% CI between 53.3% and 76.4% in concentration. Behavioral response of fish fingerling exposed to peat water ≥ 40% in the beginning 2 hours was frequently swimming up to surface.  Lethal responses fingerlings were frequently taking up oxygen to the water surface, horizontally swimming, and moving vertically before death.  After death, the fish ran out of mucus, and the skin looked peeling and bruising.
Influence of In-stream Ecosystem Restoration Techniques on the Fish Ecology of the River Nabongo in Eastern Uganda
Authors: Turyahabwe Remigio , Nabalegwa Muhamud Wambedde , Asaba Joyfred , Mulabbi Andrew
Published: December 2022

The study was the first in Uganda to assess the responses of fish community assemblages to introduced woody debris structures in a tropical river in Eastern Uganda. For comparison purposes, two different woody debris structures (simple and complex) were introduced in river Nabongo, and their effect on fish assemblage and feeding was established based on experiments conducted in two heterogeneous stream environments (a pool and a riffle). Results showed that sampling plots treated with restoration structures registered higher fish species richness, diversity, and abundance than sampling plots without restoration structures (control plots) at each site. The study (experiment) applied a stratified sampling design which used purposive identification of a pool and a riffle in River Nabongo Catchment. Fish were captured using a drift net, an electro-fishing gear, and a hand net. Data were analysed using a one-way ANOVA generated from STATA version 14. At the pool site, total fish density varied significantly from plot to plot (P<0.05) but was highest in the complex structures with 64±1.08 fishes/m2 and lowest with 24±0.82 fishes/m2 in untreated plots. K-factor did not vary significantly in untreated plots at the pool site but significantly differed from treated plots at P<0.05. The relative abundance of fish species at the pool site was highest in the complex structures with 40.7±0.66% and 21.5±0.42% before structures but was least in the control plot, varying significantly from plot to plot at P<0.05. It was concluded that woody debris restoration is an effective stream restoration technique. Fish individuals, trophic groups, and taxa more densely colonised sampling plots that had structures than those that did not have structures.
EVALUATION OF PROTECTIVE EFFECT OF AEGLE MARMELOS FRUITS EXTRACTS AGAINST STREPTOZOTOCIN-INDUCED TYPE 1 DIABETES MELLITUS IN RAT’S MODEL
Authors: AL-SHAMI ALI SALMAN , JHA DEEPAK KUMAR , BABUKUTTY BLESSY ELIZABETH , HAQUE MOHIBUL , KHADKA JEEVAN
Published: December 2022

Objective: The present study aims to investigate the activity of methanolic extract of Aegle marmelos on Type I anti-diabetic in STZ induced in rat’s model.
Methods: Extracted A. marmelos fruits were evaluated for anti-diabetic activity. Type I Diabetes has been induced in Wistar rats through STZ 65 mg/ kg/b.w.I.P. During the experiment, the rat’s body weight and fasting blood sugar levels were monitored. At the end of the study, animals in all groups have been sacrificed and biochemical parameters such as lipid profile, C-Peptide, HbA1c, serum insulin, pancreatic insulin, and histology of the pancreas have been observed. Furthermore, levels of antioxidant enzymes superoxide dismutase, catalase, and lipid peroxidation were measured.
Results: The observed extract A. marmelos was proven to be safe in the toxicity findings. It has been shown an in vivo significant effect to manage diabetic markers such as weight gain, blood glucose, lipid profile, C-Peptide, HbA1c, the release of insulin secretion, and pancreatic insulin. The diabetic pancreas of rats has been observed to fall over beta cell density and disruption of normal architecture, but treated groups have been determined to restore the mass over beta cells. Elevated oxidative enzymes also have been viewed to control the treatment with A. marmelos.
Conclusion: All its findings and phytoconstituents existing inside the extract must stay the viable chemical materials involved in the prevention of diabetes
COMPARISON OF BUPIVACAINE VERSUS BUPIVACAINE WITH FENTANYL INTRATHECALLY IN CESAREAN SECTION
Authors: PRAJAPATI JAYSHRI , BAYER REKHA , PRAJAPATI HIMANSHU
Published: December 2022

Objectives: The objectives of the study were to evaluate the efficacy and safety of fentanyl with hyperbaric bupivacaine in spinal anesthesia for caesarean section.
Methods: This prospective observational study was conducted in anesthesia department of tertiary care teaching hospital of Gujarat. Group A was given 2.0 ml of 0.5% hyperbaric bupivacaine with 0.25 ml of normal saline and Group B received 2.0 ml of 0.5% hyperbaric bupivacaine with 0.25 ml of injection fentanyl (12.5 μg). Characteristics of sensory blockade, motor blockade, analgesia, APGAR score, surgical variables, hemodynamic parameters, and complications were noted and compared in both the groups.
Results: There was no significant difference in onset of sensory block in both groups (p>0.05) but there was statistically significant difference present regarding duration of regression of sensory blockade (p<0.05). Time of motor onset and time to get Grade 0 from Grade 3 block were comparable in both groups (p>0.05). Duration of complete analgesia and duration of effective analgesia were significantly prolonged in Group B as compared to Group A (p<0.001). There was also no statistically significant difference observed in mean pulse rate, systolic blood pressure and diastolic blood pressure, and mean arterial pressure in both the groups during entire period of time (p>0.05).
Conclusions: The present study concluded that intrathecal fentanyl 12.5 μg with bupivacaine produce prolonged sensory block as well as post-operative analgesia compared to bupivacaine alone for cesarean section with insignificant hemodynamic changes without affecting neonatal outcome.
EPIDEMIOLOGICAL STUDY OF ILEAL PERFORATION IN PATIENTS PRESENTING TO TERTIARY CARE CENTRE IN NORTH-WEST RAJASTHAN
Authors: ALLA SONALI , CHOUDHARY RENUKA , MIDDHA SAHIL , SALIM MOHD
Published: December 2022

Objective: We organized an investigation to study epidemiology and various factors affecting morbidity and mortality of ileal perforation.
Methods: This study is a hospital-based prospective and descriptive study of patients admitted from November 2020 to October 2021. Fifty patients of ileal perforation who were admitted in P.B.M. Hospital during this period have been included in the study.
Results: Typhoid fever accounting for 34% of total cases, 42% were treated by ileostomy, 34 had complications. Out of 50 cases, 34 had complications around half cases had wound dehiscence. Ileostomy was the most common (n=21, 42%) surgical procedure done in cases of ileal perforation. Wound dehiscence was the most common (n=19, 55.88%) post-operative complication observed among study subjects.
Conclusion: Early diagnosis is essential since a proper diagnosis and its therapy are essential to the prognosis. Traumatic perforations have a positive outcome since the lag time is usually short. The kind of surgery performed has no effect on the death rate; however, stoma development is linked to less problems.
UTERINE FIBROIDS: SYMPTOMS SEVERITY AND ITS IMPACT ON HEALTH-RELATED QUALITY OF LIFE AMONG WOMEN IN REPRODUCTIVE AGE GROUP IN NORTH KERALA
Authors: ANTONY V ABHILASH , T HEERA SHENOY , SHIVAKUMAR  , VK CHELLAMMA , HASHIM HIBA
Published: December 2022

Objectives: This study was conducted to determine the effect of uterine fibroids (UFs) and their symptoms severity and its impact on health-related quality of life (QoL) among women in reproductive age group reporting to a teaching medical institution in the state of Kerala.
Methods: The questionnaire QoL-life quality of patients with symptomatic UF was used to assess their QoL in 104 women attending outpatient department at KMCT Medical College from March 2021 to August 2021.
Results: Mean age was 45.86. About 34.62% of cases were in Obesity I category; followed by 13.46% of Obesity II. About 33.65% had UF with corporeal location; 44.23% in cervical and 22.12% had isthmic fibroids. About 32.69% showed presence of sub-serous; 42.67% had intramural and 24.04% had submucosal fibroid. HMB followed by abdominal pain and bladder dysfunction was the presenting features.
Conclusion: There was a strong negative correlation between symptoms and the UF QoL. This shows that with the increase in symptoms; the QoL was reduced in all the overall aspects. Hence, it was concluded that UF has a profound negative impact on the overall QoL in reproductive age women.
A CASE REPORT ON WELL KNOWN BUT HAS TO BE REPORTED ADVERSE EFFECT OF PHENYTOIN-INDUCED RASH AND ASSESSMENT OF ITS SEVERITY BASED ON ADVERSE DRUG REACTION REPORTING SCALES
Authors: KAUR AMANJOT , SINGH JASNINDER
Published: December 2022

Phenytoin is an aromatic antiepileptic drug, commonly used for the purpose of treating generalized tonic clonic and partial seizures. The drug has been known to cause hypersensitivity reaction, which can be life-threatening by involving internal organs, and is referred as anticonvulsant hypersensitivity syndrome. The treatment in such cases is the immediate discontinuation of the agent causing the reaction and replacing the treatment with other non-aromatic anticonvulsant agent. This case report presents an adverse drug reaction and occurs within 1 week of starting the treatment, a well-known but has to report this adverse effect.
DACLATASVIR DIHYDROCHLORIDE MICROSPHERES, PROCESS PARAMETERS FOR ENHANCED PERMEABILITY AND LIVER TARGETING
Authors: K SUDHAMANI , JYOTHI B JEEVANA
Published: December 2022

Objectives: Daclatasavir dihydrochloride (DCLD) is used to treat hepatitis C. DCLD can be used to patients with all stages of compensated liver disease including cirrhosis. The aim of the present study was to develop DCLD microspheres to improve the permeation and maximum accumulation in the liver and in vitro evaluation.
Methods: DCLD microspheres were prepared with chitosan polymer using emulsion crosslinking technique. Twelve formulations were prepared, that is, F1-F12. The microspheres were evaluated for morphology, particle size, encapsulation efficiency, % yield, and permeability. FTIR studies were conducted on optimized formulation to check the drug-excipient compatibility.
Results: The particle size of microspheres was in the range of 11.50±0.08 μm to 98.50±0.05 μm. Encapsulation efficiency of the formulations was observed in the range 47.8–69.2%. The ex vivo permeation studies revealed that 83.3±0.1% of drug was diffused from microspheres in 60 min, whereas from pure drug 49±0.7% of drug was diffused in 60 min.
Conclusion: DCLD microspheres were shown good permeability when compared to pure drug which will improve the absorption.
CLINICAL EFFICACY OF HIGH DOSE WATER-SOLUBLE VITAMINS SUPPLEMENTATION ON LIPID PROFILE IN PRE-HYPERTENSIVE SUBJECTS
Authors: TALIKOTI PRASHANTH
Published: December 2022

Background: Hypertension (HTN) is one of the preventable cardiovascular diseases (CVD) but it causes significant morbidity and mortality. Recently, incidence of pre-hypertension is increasing and it has a greater chance of developing into HTN. Dyslipidemia is one of the main risk factors for the development of CVD among the pre-hypertensive subjects. Water soluble vitamins display potent antioxidant and anti-inflammatory effects and also elicits favorable effect on lipid profile in HTN. In this backdrop, the present study was carried out to evaluate the supplementation of water-soluble vitamins on lipid profile in pre-hypertensive patients.
Methods: This was a randomized, single blinded, and placebo-controlled study conducted on 60 pre-hypertensive subjects and was allocated into water soluble vitamins group (n=30) and received Becosules capsule for 4 months and placebo group (n=30) received starch capsule for 4 months. The blood was withdrawn at 2–4 months and the lipid profiles such as total cholesterol, triacylglycerol, HDL cholesterol (HDL-C), low-density lipoprotein (LDL)-C, and VLDL were measured. Then, the lipid profiles were compared with in the group and between the groups at 2–4 months using two-way repeated measures ANOVA.
Results: In this study, the triglycerides and VLDL level were significantly (p<0.05) decreased in water soluble vitamin groups as compared to the placebo groups. Meanwhile there was no significant alteration in the total cholesterol, HDL-C, and LDL-C level between the groups.
Conclusion: Thus, the study shows that water soluble vitamins displayed significant anti-dyslipidemia effect in pre-hypertension and might also confer protection in the future progression of HTN.
Energy balance in maize (Zea mays L.)
Authors: Neto Benjamim Pereira da Costa
Published: December 2022

Corn is a crop of wide importance worldwide and is present in many items of the human and animal diet. It is a plant that has a very large photosynthetic capacity due to its C4 metabolism, a highly efficient mechanism in terms of atmospheric carbon uptake and transformation into biochemical energy. Thus, this work aimed to calculate, through the enthalpies of chemical bonds, the energy produced by a corn plant during its cycle. The data obtained during the study were obtained from the results of scientific research on plant development. From the obtained results, it was possible to observe that corn produces a lot of energy during a cycle and that the energy stored in the grains produced by the plant is completely negligible compared to that produced. Therefore, this study proves the idea that the plant consumes, in respiration, only 40 to 60% of what was produced in photosynthesis, which would require further studies to elucidate this issue.
An Importance of Information Technology and Computer Applications Among Students in Kannanur
Authors: Velmurugan N. , Lalitha T. , Mukilan Dr. T.
Published: December 2022

Abstract: Computers and information technology and computer are critical components of modern society. In the meantime, education in information technology and computer applications has opened up new employment opportunities in Information Technology fields. The educational institution then began offering a variety of degrees through colleges, making a unique contribution to information technology and computer education. Colleges unquestionably have a significant impact on many facets of education and enhance both teaching and learning quality. The educational system, including schools, colleges, and universities, has been improved through the use of numerous computer technologies and applications. To effectively manage their institution's learning, teaching, administration, and accounting processes, educational institutions today use their own computer applications. In order for students to learn effectively, they need to be aware of how computers affect both their subjects and education. Students are able to recognize that integrated technology will enhance classroom learning thanks to information technology and computer applications. The purpose of this study is to determine that students place a high value on information technology and computer applications. The present study finds that college students' advancement in information technology and computer applications. The study reveals the numerous usages of information technology and computer applications importance among students. As a result, the information technology and computer applications were used in college education make it possible for students and teachers to learn and teach effectively.
Correlation Between Urban Literacy Rate and Urban Sex Ratio in Parbhani District Maharashtra: A Geographical Analysis
Authors: Solanke Ajitsing S. , A Khadke P.
Published: December 2022

Abstract: This article investigates the correlation between urban literacy and the urban sex ratio in the Parbhani district. Education forms an important component in the overall development of individuals, enabling them to have greater awareness, and better comprehension of their social, political, and cultural environment and also facilitating the importance of their socioeconomic conditions. Literacy rate (LR) is defined as the percentage of literates among the population aged seven years and above. Literacy is one of the significant indicators for the overall development of the human being. The sex ratio is used to determine gender equality in the population. In India, the number of females per 1000 males determines the sex ratio of the people. The literacy rate of the total population of the urban Parbhani district has increased from 52.58 percent to 69.21 percent in 1991 and in 2011 respectively. The increasing percentage is 16.63 during the two-decade period in the district. There is an overall development in the literacy rate of the district.in 1991 the urban sex ratio of the district was 924 and according to the census of 2011, the sex ratio is 958 respectively.
Music Generation Using Recurrent Neural Networks
Authors: Joshi Atharva , Gokhale Atharva , Khandekar Arnav , Kesar Aalok , Khade Shaunak , Tarapore Noshir
Published: December 2022

Abstract: Over the past years music has been continually evolving through the its tempos and beats as well as it’s melody. Traditionally, music is produced by a group of musicians with different instruments combining together to create a final synchronised product. In recent years, harmonies and beats were always considered to be generated manually. However, with the advent of digital technologies and software, it has become possible for machines to generate music automatically at an alarming pace. The purpose of this research is to propose a method for creating musical notes using Recurrent Neural Networks (RNN), specifically Long Short-Term Memory (LSTM)networks. To implement this algorithm, a model is created and the data is represented in the form of a percussive instrument digital interface (MIDI) file for easy access and interpretation. The process of preparing the data for input into the model isalso discussed, as well as techniques for receiving, processing, and storing MIDI files for use as input.To enhance its learning capabilities, the model should be able to remember previous details of a musical sequence and its structure. This paper discusses the use of a layered architecture in the LSTM model and how its connections interweave to create a neural network.
Dampak Aplikasi Konsorsium Mikoriza Terhadap Pertumbuhan Vegetatif Tanaman dan Perkembangan Penyakit Ganoderma di Pembibitan Kelapa Sawit
Authors: Priwiratama Hari , Gama Pradana Mahardika , Susanto Agus , Ahmad Perdana Rozziansha Tjut , Nur Istiqomah Fatimah
Published: December 2022

Penelitian untuk mengetahui dampak aplikasi konsorsium mikoriza terhadap pertumbuhan vegetatif tanaman dan tingkat kejadian penyakit Ganoderma dilakukan pada fase pembibitan kelapa sawit. Percobaan disusun dalam rancangan acak lengkap faktorial dengan dua faktor (dosis mikoriza dan waktu inokulasi Ganoderma) dan tiga taraf perlakuan pada masing-masing faktor utama yaitu dosis mikoriza sebanyak 0 g, 30 g di pre-nursery (PN) ditambah 40 g di main nursery (MN), atau 40 g di PN ditambah 50 g di MN, dengan waktu inokulasi Ganoderma pada 3 atau 6 bulan setelah tanam dan perlakuan tanpa inokulasi sebagai pembanding. Hasil penelitian menunjukkan bahwa isolat mikoriza yang digunakan dapat bersimbiosis dengan perakaran bibit kelapa sawit dengan tingkat kolonisasi antara 39,13% dan 45,74%. Aplikasi mikoriza tidak memberikan pengaruh positif terhadap pertumbuhan meninggi dan jumlah daun bibit kelapa sawit, namun berdampak signifikan terhadap perkembangan diameter bonggol yang lebih lebar. Kejadian dan intensitas penyakit Ganoderma pada tanaman dengan aplikasi mikoriza secara signifikan lebih rendah dibandingkan dengan perlakuan tanpa mikoriza. Aplikasi mikoriza mampu menekan perkembangan penyakit hingga lebih dari 50% pada seluruh dosis yang digunakan.
Technology Transfer in Foreign Higher Education Institutions: The Example of Catholic University of Leuven
Authors: Yeremchenko О. А. , Kurakova N. G.
Published: December 2022

The convergence of the scientific, educational and business sectors requires the search for new models and tools for the transfer of technology from the university environment to the work of enterprises in the real sector of the economy. On the example of the Catholic University of Leuven, approaches to the commercialization of the results of the intellectual activity of universities abroad are considered. It is shown that the active development of its own technology transfer center, which implements, among other things, initiatives in the field of mergers and acquisitions, has allowed KU Leuven to achieve outstanding results in creating its own innovation environment and take leading positions in the global rankings of world universities. The results obtained can be successfully transferred to the practice of Russian universities.
Theoretical and Methodological Provisions of Quality Management of Professional Activity of The Teaching Staff of Higher Educational Institutions
Authors: Razumova Y. V. , Trapeznikova E. M.
Published: December 2022

The article substantiates the relevance of assessing the quality of professional activity of the teaching staff of higher educational institutions in the context of the transformation of the educational process. A study of theoretical and methodological aspects of assessing the quality of work of teaching staff has been conducted. The key components of the category “quality of professional activity of the teaching staff” are identified and a definition based on the essential aspects of the selected components is formulated. The main trends characterizing the modern system of higher education (elements of the transformation of the higher education system) are also highlighted, their impact on the activities of teaching staff of higher educational institutions is analyzed and the emerging demands of the external environment for the qualification of teaching staff are highlighted. As a result of the study, the authors identified inconsistencies in the theoretical and methodological provisions of the assessment of the quality of teaching staff, in particular, inconsistencies between the normative and actual qualification and competence requirements for teaching staff in the conditions of transformation of the educational system.
Work Incentives for Sectoral Research Institute Researchers
Authors: Rimskaya O. N. , Naumenko S. N.
Published: December 2022

The article considers issues of researchers’ work assessment of sectoral research institutes in the Russian Federation. The authors investigate the advantages and disadvantages of the existing system of scientometric indicators with relation to the researchers’ publication activity increase. Practical solutions are proposed to harmonize the internal and external motivation of the researchers’ work of the sectoral research institute in order to ensure the effectiveness of their scientific activities, the implementation of key indicators of the effectiveness of scientific work and to promote the economic and innovative effect of the institute activities. The authors proposed a conceptual system for stimulating the work of researchers through authorship in scientific publications and evaluated its effectiveness. The scientific novelty lies in the development of a system of incentives for authorship in scientific publications to employees of the Railway Research Institute. The practical significance of the study lies in the possibility of applying the incentive system in many sectors of the modern economy.
Proactive Technological Policy and Import Substitution Perspectives: The Role of Testing Centers
Authors: Anokhov I. V.
Published: December 2022

The purpose of the article is the investigation of proving grounds and testing centers role in proactive technological development of the country. The object of the study is the Experimental Loop of Railway Research Institute, which have a unique, almost century-long history of testing activities. The article investigates features of reactive and proactive science and technology policy. It is proven that currently science and technology policy should have strongly marked nature. Existing methods and ways of evaluation, including Technology Readiness Level (TRL) scale may be implemented. The main development stages of the Experimental Loop internal structure and functions are analysed. The perspective ways of its development are proposed, which imply the transition from reactive to proactive technological policy in order to develop a certain branch.
HUBUNGAN ORIENTASI PERILAKU PEMIMPIN TERHADAP EMPLOYEE ENGAGEMENT DI KANTOR SUCOFINDO CABANG JAMBI DENGAN ‘TRUST’ SEBAGAI VARIABEL MEDIATOR
Authors: Huda Nurul , Rosita Sry
Published: December 2022

Penelitian ini bertujuan untuk mengidentifikasi hubungan antara orientasi perilaku pemimpin dan employee engagement pegawati PT.Sucofindo (Persero) Cabang Jambi melalui trust. Penelitian ini menggunakan metode penelitian yang bersifat deskriptif kuantitatif dengan menggunakan kuisioner sebagai teknik pengumpulan data dan software partial least square (PLS) sebagai alat analisis data. Berdasarkan hasil analisis yang dilakukan, terdapat hubungan yang positif dan signifikan antara orientasi perilaku pemimpin dengan employee engagement, orientasi perilaku pemimpin dengan trust, trust dengan employee engagement, dan hubungan yang positif dan signifikan juga ditemukan pada hubungan orientasi perilaku pemimpin dan employee engagement melalui trust. Hasil penelitian ini menunjukkan bahwa PT. Sucofindo (Persero) Cabang Jambi harus dapat selalu meningkatkan gaya kepimimpinan yang memiliki orientasi dalam berperilaku serta dapat meningkatkan trust pegawai terhadap pemimpin itu sendiri maupun organisasi secara umum.

Kata Kunci: Orientasi perilaku pemimpin, employee engagement, trust, PT. Sucofindo (Persero) Cabang Jambi