bluuebunny/crossref_metadata_2025 huggingface dataset:
Estimating the global burden of Epstein–Barr virus-related cancers
Authors: Wong Yide , Meehan Michael T. , Burrows Scott R. , Doolan Denise L. , Miles John J.
Published: October 2021

Background

More than 90% of the adult population globally is chronically infected by the Epstein–Barr virus (EBV). It is well established that EBV is associated with a number of malignancies, and advances in knowledge of EBV-related malignancies are being made every year. Several studies have analysed the global epidemiology and geographic distribution of EBV-related cancers. However, most have only described a single cancer type or subtype in isolation or limited their study to the three or four most common EBV-related cancers. This review will present an overview on the spectrum of cancers linked to EBV based on observations of associations and proportions in the published literature while also using these observations to estimate the incidence and mortality burden of some of these cancers.

Method

We have reviewed the literature on defining features, distribution and outcomes across six cancers with a relatively large EBV-related case burden: Nasopharyngeal carcinoma (NPC), Gastric carcinoma (GC), Hodgkin lymphoma (HL), Burkitt lymphoma (BL), Diffuse large B-cell lymphoma (DLBCL) and Extranodal NK/T-cell lymphoma, Nasal type (ENKTL-NT). We retrieved published region-specific EBV-related case proportions for NPC, GC, HL and BL and performed meta-analyses on pooled region-specific studies of EBV-related case proportions for DLBCL and ENKTL-NT. We match these pooled proportions with their respective regional incidence and mortality numbers retrieved from a publicly available cancer database. Additionally, we also reviewed the literature on several other less common EBV-related cancers to summarize their key characteristics herein.

Conclusion

We estimated that EBV-related cases from these six cancers accounted for 239,700–357,900 new cases and 137,900–208,700 deaths in 2020. This review highlights the significant global impact of EBV-related cancers and extends the spectrum of disease that could benefit from an EBV-specific therapeutic.
Population pharmacokinetic model selection assisted by machine learning
Authors: Sibieude Emeric , Khandelwal Akash , Girard Pascal , Hesthaven Jan S. , Terranova Nadia
Published: October 2021

A fit-for-purpose structural and statistical model is the first major requirement in population pharmacometric model development. In this manuscript we discuss how this complex and computationally intensive task could benefit from supervised machine learning algorithms. We compared the classical pharmacometric approach with two machine learning methods, genetic algorithm and neural networks, in different scenarios based on simulated pharmacokinetic data. Genetic algorithm performance was assessed using a fitness function based on log-likelihood, whilst neural networks were trained using mean square error or binary cross-entropy loss. Machine learning provided a selection based only on statistical rules and achieved accurate selection. The minimization process of genetic algorithm was successful at allowing the algorithm to select plausible models. Neural network classification tasks achieved the most accurate results. Neural network regression tasks were less precise than neural network classification and genetic algorithm methods. The computational gain obtained by using machine learning was substantial, especially in the case of neural networks. We demonstrated that machine learning methods can greatly increase the efficiency of pharmacokinetic population model selection in case of large datasets or complex models requiring long run-times. Our results suggest that machine learning approaches can achieve a first fast selection of models which can be followed by more conventional pharmacometric approaches.
Formal and informal entrepreneurship: a cross-country policy perspective
Authors: Laing Elaine , van Stel André , Storey David J.
Published: October 2021

This paper distinguishes between formal and informal entrepreneurship. It theorises that each are influenced by very different combinations of macro-economic factors and strongly moderated by country income levels. Empirically, we show the ease of starting a business and high-quality governance, exert a powerful influence on formal, but not informal entrepreneurship. The latter is influenced by self-employment rates in low-income countries and by female labour force participation in high-income countries. Policy-makers seeking to improve economic welfare through enhancing entrepreneurship therefore have to choose the ‘type’ of entrepreneurship on which to focus and then select appropriate policies. By providing a novel grouping of these policies, we are able to assist them in making these choices.
Bullying in Five European Countries: Evidence for Bringing Gendered Phenomena Under the Umbrella of ‘Sexual Bullying’ in Research and Practice
Authors: Turner-Moore Rhys , Milnes Kate , Gough Brendan
Published: October 2021

Sexual bullying refers to bullying or harassment that is sexualised, related to sexuality, and/or related to gender expression (Duncan, 1999). Research on sexual bullying is disparate and still developing as a field. This study extends on this research through a mixed-methods analysis of the different forms of sexual bullying and the relationships between them across five European nations. Participants were 253 young people (aged 13–18) from Bulgaria, England, Italy, Latvia and Slovenia. As part of focus groups on sexual bullying, participants individually and anonymously completed a Sexual Bullying Questionnaire (SBQ), comprising closed- and open-ended questions about their experiences of victimisation and bullying their peers. Factor analysis identified five forms of sexual bullying victimisation and two forms of sexual bullying towards peers. The quantitative and qualitative findings indicated that bullying or harassment that is sexualised, related to sexuality, and/or related to gender expression are associated with each other. Further, sexual bullying was found to be common to all five European countries indicating that it is a cross-national issue. The associations between sexualised, sexuality and gender expression bullying or harassment support the use of the term sexual bullying to unite these forms of peer victimisation in research and practice. Further, all countries studied require initiatives to address sexual bullying, and the gender and sexual norms that may contribute to it, with tailoring to the country context.
Scheduling Hardware-Accelerated Cloud Functions
Authors: Vandebon Jessica , Coutinho Jose G. F. , Luk Wayne
Published: October 2021

This paper presents a Function-as-a-Service (FaaS) approach for deploying managed cloud functions onto heterogeneous cloud infrastructures. Current FaaS systems, such as AWS Lambda, allow domain-specific functionality, such as AI, HPC and image processing, to be deployed in the cloud while abstracting users from infrastructure and platform concerns. Existing approaches, however, use a single type of resource configuration to execute all function requests. In this paper, we present a novel FaaS approach that allows cloud functions to be effectively executed across heterogeneous compute resources, including hardware accelerators such as GPUs and FPGAs. We implement heterogeneous scheduling to tailor resource selection to each request, taking into account performance and cost concerns. In this way, our approach makes use of different processor types and quantities (e.g. 2 CPU cores), uniquely suited to handle different types of workload, potentially providing improved performance at a reduced cost. We validate our approach in three application domains: machine learning, bio-informatics, and physics, and target a hardware platform with a combined computational capacity of 24 FPGAs and 12 CPU cores. Compared to traditional FaaS, our approach achieves a cost improvement for non-uniform traffic of up to 8.9 times, while maintaining performance objectives.
Educational Expectations of Left-behind Children in China: Determinants and Gender Differences
Authors: Huang Yeqing , Gong Huihui
Published: October 2021

In response to the relatively low educational attainment of left-behind children in China, this article examines the determinants of educational expectations among left-behind children and how these differ by gender by analyzing data collected from 2215 left-behind children in southwestern China. Multinomial logistic regression models of educational expectations that incorporate family economic status, care arrangement under different parental migration patterns, and significant others are tested by gender and school level. The results prove that all of the above incorporated factors affect the educational expectations of left-behind children to a considerable extent. Comparisons of educational expectations are made between left-behind children in primary school and junior high school and between different genders. The results show that male advantages in educational expectations exist only during primary school, and female left-behind children surpass male children to have higher educational expectations during junior high school. This suggests a distinctive influence of care arrangements on educational expectations between genders. For female children, grandparental care and a higher frequency of parental contact during migration could be substituted for parental absence. However, for male children, grandparental care does not fully substitute for parental care, and parental migration seems to be more detrimental to them. The findings add to our understanding of the dynamic relationship among parental migration, gender inequality, and educational opportunity among left-behind children in general.
Coaching zum Spannungsfeld von Dominanz und Unterordnung – Perspektiven für eine situationsadäquate Selbstregulation
Authors: Stoll Michael
Published: October 2021

Die Forschung widmete sich der Frage, wie Einzelcoaching dazu beiträgt, dass Coachees eine situationsadäquate Selbstregulation von Dominanz und Unterordnung gelingt. Zunächst wird die Relevanz des Themas für die Coachingpraxis und das Spannungsfeld von Dominanz und Unterordnung erörtert. Das Instrument der operationalisierten psychodynamischen Diagnostik diente als Grundlage für das Forschungsdesign. Anschließend wird die verwendete Methode beschrieben, und die Ergebnisse der Forschung werden komprimiert dargelegt. Schließlich werden einzelne inhaltliche Kernaspekte diskutiert und Implikationen für die Beratungspraxis angeführt.
A Young Japanese Patient with Spinocerebellar Ataxia Type 3 Presenting Depressive State with Cenesthopathy and Delusion: a Case Report
Authors: Okamoto Naomichi , Ikenouchi Atsuko , Ide Satoru , Hashimoto Yu , Yoshimura Reiji
Published: October 2021

Depressive state is a common complication of spinocerebellar ataxia type 3 (SCA3). To the best of our knowledge, cases of SCA3 presenting with cenesthopathy have not been described. Here, we present a case of a severe depressive state with cenesthopathy and delusion in a young Japanese man with SCA3. A 43-year-old Japanese man with SCA3 developed a severe depressive state with associated cenesthopathy and delusion. He was treated with escitalopram (10 mg/day) and olanzapine (2.5 mg/day). Computed tomography showed atrophy of the cerebellum, bilateral superior cerebellar peduncle, and tegmentum of the pons. Single-photon emission computed tomography demonstrated reduced blood flow in the cerebellum, vermis, and brainstem. After 8 weeks, his depressive state and delusion improved; however, his cenesthopathy persisted. We encountered a case of a severe depressive state with cenesthopathy and delusion in a young Japanese man with SCA3. This case supports previous studies that the cerebellum could have a role beyond motor functions.
Explaining Dynamic Changes in Various Asset’s Relationships in Financial Markets
Authors: Naraoka Makoto , Hayashi Teruaki , Yoshino Takaaki , Sugie Toshiaki , Takano Kota , Ohsawa Yukio
Published: October 2021

We study the method for detecting relationship changes in financial markets and providing human-interpretable network visualization to support the decision-making of fund managers dealing with multi-assets. First, we construct co-occurrence networks with each asset as a node and a pair with a strong relationship in price change as an edge at each time step. Second, we calculate Graph-Based Entropy to represent the variety of price changes based on the network. Third, we apply the Differential Network to finance, which is traditionally used in the field of bioinformatics. By the method described above, we can visualize when and what kind of changes are occurring in the financial market, and which assets play a central role in changes in financial markets. Experiments with multi-asset time-series data showed results that were well fit with actual events while maintaining high interpretability. It is suggested that this approach is useful for fund managers to use as a new option for decision-making.
Action recognition based on dynamic mode decomposition
Authors: Dong Shuai , Zhang Weixi , Wang Wei , Zou Kun
Published: October 2021

Based on dynamic mode decomposition (DMD), a new empirical feature for quasi-few-shot setting (QFSS) skeleton-based action recognition (SAR) is proposed in this study. DMD linearizes the system and extracts the modes in the form of flattened system matrix or stacked eigenvalues, named the DMD feature. The DMD feature has three advantages. The first advantage is its translational and rotational invariance with respect to the change in the localization and pose of the camera. The second one is its clear physical meaning, that is, if a skeleton trajectory was treated as the output of a nonlinear closed-loop system, then the modes of the system represent the intrinsic dynamic property of the motion. Finally, the last one is its compact length and its simple calculation without training. The information contained by the DMD feature is not as complete as that of the feature extracted using a deep convolutional neural network (CNN). However, the DMD feature can be concatenated with CNN features to greatly improve their performance in QFSS tasks, in which we do not have adequate samples to train a deep CNN directly or numerous support sets for standard few-shot learning methods. Four QFSS datasets of SAR named CMU, Badminton, miniNTU-xsub, and miniNTU-xview, are established based on the widely used public datasets to validate the performance of the DMD feature. A group of experiments is conducted to analyze intrinsic properties of DMD, whereas another group focuses on its auxiliary functions. Experimental results show that the DMD feature can improve the performance of most typical CNN features in QFSS SAR tasks.
Parental Conflicts and Posttraumatic Stress of Children in High-Conflict Divorce Families
Authors: Lange Aurelie M. C. , Visser Margreet M. , Scholte Ron H. J. , Finkenauer Catrin
Published: October 2021

Parental conflicts consistently predict negative outcomes for children. Research suggests that children from high-conflict divorces (HCD) may also experience post-traumatic stress symptoms (PTSS), yet little is known about the association between parental conflicts in HCD families and child PTSS. We investigated this association, hypothesizing that parental conflicts would predict child PTSS. We also tested the moderating role of interparental contact frequency, hypothesizing that frequent contact would intensify the association between parental conflicts and child PTSS. This study was part of an observational study on the outcomes of No Kids in the Middle (NKM), a multi-family group intervention for HCD families. A total of 107 children from 68 families participated in the study with at least one parent. We used pre- (T1) and post-intervention (T2) data. Research questions were addressed cross-sectionally, using regression analyses to predict PTSS at T1, and longitudinally, using a correlated change (T1 to T2) model. The cross-sectional findings suggested that mother- and child-reported conflicts, but not father-reported conflicts, were related to the severity of child PTSS. Longitudinally, we found that change in father-reported conflicts, but not change in child- or mother-reported conflicts, were related to change in child PTSS. The estimated associations for the different informants were not significantly different from one another. The frequency of contact between ex-partners did not moderate the relationship between parental conflicts and child PTSS. We conclude that there is a positive association between parental conflicts and child PTSS in HCD families independent of who reports on the conflicts.
Photodynamic disinfection and its role in controlling infectious diseases
Authors: Aroso Rafael T. , Schaberle Fábio A. , Arnaut Luís G. , Pereira Mariette M.
Published: October 2021

Photodynamic therapy is witnessing a revival of its origins as a response to the rise of multi-drug resistant infections and the shortage of new classes of antibiotics. Photodynamic disinfection (PDDI) of microorganisms is making progresses in preclinical models and in clinical cases, and the perception of its role in the clinical armamentarium for the management of infectious diseases is changing. We review the positioning of PDDI from the perspective of its ability to respond to clinical needs. Emphasis is placed on the pipeline of photosensitizers that proved effective to inactivate biofilms, showed efficacy in animal models of infectious diseases or reached clinical trials. Novel opportunities resulting from the COVID-19 pandemic are briefly discussed. The molecular features of promising photosensitizers are emphasized and contrasted with those of photosensitizers used in the treatment of solid tumors. The development of photosensitizers has been accompanied by the fabrication of a variety of affordable and customizable light sources. We critically discuss the combination between photosensitizer and light source properties that may leverage PDDI and expand its applications to wider markets. The success of PDDI in the management of infectious diseases will ultimately depend on the efficacy of photosensitizers, affordability of the light sources, simplicity of the procedures, and availability of fast and efficient treatments.

Graphic abstract
Integrins, cadherins and channels in cartilage mechanotransduction: perspectives for future regeneration strategies
Authors: Dieterle Martin Philipp , Husari Ayman , Rolauffs Bernd , Steinberg Thorsten , Tomakidi Pascal
Published: October 2021

Articular cartilage consists of hyaline cartilage, is a major constituent of the human musculoskeletal system and has critical functions in frictionless joint movement and articular homoeostasis. Osteoarthritis (OA) is an inflammatory disease of articular cartilage, which promotes joint degeneration. Although it affects millions of people, there are no satisfying therapies that address this disease at the molecular level. Therefore, tissue regeneration approaches aim at modifying chondrocyte biology to mitigate the consequences of OA. This requires appropriate biochemical and biophysical stimulation of cells. Regarding the latter, mechanotransduction of chondrocytes and their precursor cells has become increasingly important over the last few decades. Mechanotransduction is the transformation of external biophysical stimuli into intracellular biochemical signals, involving sensor molecules at the cell surface and intracellular signalling molecules, so-called mechano-sensors and -transducers. These signalling events determine cell behaviour. Mechanotransducing ion channels and gap junctions additionally govern chondrocyte physiology. It is of great scientific and medical interest to induce a specific cell behaviour by controlling these mechanotransduction pathways and to translate this knowledge into regenerative clinical therapies. This review therefore focuses on the mechanotransduction properties of integrins, cadherins and ion channels in cartilaginous tissues to provide perspectives for cartilage regeneration.
Squarefree Integers in Arithmetic Progressions to Smooth Moduli
Authors: Mangerel Alexander P.
Published: October 2021

Let

$\varepsilon> 0$

be sufficiently small and let

$0 < \eta < 1/522$

. We show that if X is large enough in terms of

$\varepsilon $

, then for any squarefree integer

$q \leq X^{196/261-\varepsilon }$

that is

$X^{\eta }$

-smooth one can obtain an asymptotic formula with power-saving error term for the number of squarefree integers in an arithmetic progression

$a \pmod {q}$

, with

$(a,q) = 1$

. In the case of squarefree, smooth moduli this improves upon previous work of Nunes, in which

$196/261 = 0.75096\ldots $

was replaced by

$25/36 = 0.69\overline {4}$

. This also establishes a level of distribution for a positive density set of moduli that improves upon a result of Hooley. We show more generally that one can break the

$X^{3/4}$

-barrier for a density 1 set of

$X^{\eta }$

-smooth moduli q (without the squarefree condition).

Our proof appeals to the q-analogue of the van der Corput method of exponential sums, due to Heath-Brown, to reduce the task to estimating correlations of certain Kloosterman-type complete exponential sums modulo prime powers. In the prime case we obtain a power-saving bound via a cohomological treatment of these complete sums, while in the higher prime power case we establish savings of this kind using p-adic methods.
Transition study for asymmetric reflection between moving incident shock waves
Authors: Wang Miao-Miao , Wu Zi-Niu
Published: October 2021

The transition criteria seen from the ground frame are studied in this paper for asymmetrical reflection between shock waves moving at constant linear speed. To limit the size of the parameter space, these criteria are considered in detail for the reduced problem where the upper incident shock wave is moving and the lower one is steady, and a method is provided for extension to the general problem where both the upper and lower ones are unsteady. For the reduced problem, we observe that, in the shock angle plane, shock motion lowers or elevates the von Neumann condition in a global way depending on the direction of shock motion, and this change becomes less important for large shock angle. The effect of shock motion on the detachment condition, though small, displays non-monotonicity. The shock motion changes the transition criteria through altering the effective Mach number and shock angle, and these effects add for small shock angle and mutually cancel for large shock angle, so that shock motion has a less important effect for large shock angle. The role of the effective shock angle is not monotonic on the detachment condition, explaining the observed non-monotonicity for the role of shock motion on the detachment condition. Furthermore, it is found that the detachment condition has a wavefunction form that can be approximated as a hybrid of a sinusoidal function and a linear function of the shock angle.
Modulation of elasto-inertial transitions in Taylor–Couette flow by small particles
Authors: Lacassagne Tom , Boulafentis Theofilos , Cagney Neil , Balabani Stavroula
Published: October 2021

Particle suspensions in non-Newtonian liquid matrices are frequently encountered in nature and industrial applications. We here study the Taylor–Couette flow (TCF) of semidilute spherical particle suspensions (volume fraction

$\leq 0.1$

) in viscoelastic, constant-viscosity liquids (Boger fluids). We describe the influence of particle load on various flow transitions encountered in TCF of such fluids, and on the nature of these transitions. Particle addition is found to delay the onset of first- and second-order transitions, thus stabilising laminar flows. It also renders them hysteretic, suggesting an effect on the nature of bifurcations. The transition to elasto-inertial turbulence (EIT) is shown to be delayed by the presence of particles, and the features of EIT altered, with preserved spatio-temporal large scales. These results imply that particle loading and viscoelasticity, which are known to destabilise the flow when considered separately, can on the other hand compete with one another and ultimately stabilise the flow when considered together.
On an eddy viscosity model for energetic deep-water surface gravity wave breaking
Authors: Khait Anatoliy , Ma Zhihua
Published: October 2021

We present an investigation of the fundamental physical processes involved in deep-water gravity wave breaking. Our motivation is to identify the underlying reason causing the deficiency of the eddy viscosity breaking model (EVBM) in predicting surface elevation for strongly nonlinear waves. Owing to the limitation of experimental methods in the provision of high-resolution flow information, we propose a numerical methodology by developing an EVBM enclosed standalone fully nonlinear quasi-potential (FNP) flow model and a coupled FNP plus Navier–Stokes flow model. The numerical models were firstly verified with a wave train subject to modulational instability, then used to simulate a series of broad-banded focusing wave trains under non-, moderate- and strong-breaking conditions. A systematic analysis was carried out to investigate the discrepancies of numerical solutions produced by the two models in surface elevation and other important physical properties. It is found that EVBM predicts accurately the energy dissipated by breaking and the amplitude spectrum of free waves in terms of magnitude, but fails to capture accurately breaking induced phase shifting. The shift of phase grows with breaking intensity and is especially strong for high-wavenumber components. This is identified as a cause of the upshift of the wave dispersion relation, which increases the frequencies of large-wavenumber components. Such a variation drives large-wavenumber components to propagate at nearly the same speed, which is significantly higher than the linear dispersion levels. This suppresses the instant dispersive spreading of harmonics after the focal point, prolonging the lifespan of focused waves and expanding their propagation space.
Asymptotic analysis of initial flow around an impulsively started circular cylinder using a Brinkman penalization method
Authors: Ueda Y. , Kida T.
Published: October 2021

The initial flow past an impulsively started translating circular cylinder is asymptotically analysed using a Brinkman penalization method on the Navier–Stokes equations. The asymptotic solution obtained shows that the tangential and normal slip velocities on the cylinder surface are of the order of

$1/\sqrt {\lambda }$

and

$1/\lambda$

, respectively, within the second approximation of the present asymptotic analysis, where

$\lambda$

is the penalization parameter. This result agrees with the estimation of Carbou & Fabrie (Adv. Diff. Equ., vol. 8, 2003, pp. 1453–1480). Based on the asymptotic solution, the influence of the penalization parameter

$\lambda$

is discussed on the drag coefficient that is calculated using the adopted three formulae. It can then be found that the drag coefficient calculated from the integration of the penalization term exhibits a half-value of the results of Bar-Lev & Yang (J. Fluid Mech., vol. 72, 1975, pp. 625–647) as

$\lambda \to \infty$

.
Resilience, well-being, and organizational outcomes of Croatian, Thai, and US workers during COVID-19
Authors: Charoensap-Kelly Piyawan , Sheldon Pavica , Grace Antony Mary , Provenzani Laura
Published: October 2021

Drawing on social cognitive theory (SCT), this study examines the effects of employee resilience, through well-being, on job productivity, and relational satisfaction among extraverted versus introverted workers in Croatia, Thailand, and the United States during the early period of the coronavirus disease 2019 pandemic. Participants included 832 working adults from various industries. Moderated mediation analyses revealed employee resilience positively predicted psychological well-being which, in turn, positively predicted both productivity and relational satisfaction. Regardless of culture, extraverted workers reported less productivity but greater satisfaction with coworkers compared to introverted workers. Also, resilience dampened the negative effects of introversion on relational satisfaction. The findings support the multilevel perspective of resilience and SCT assertion that behavioral outcomes are determined by an interaction between personal and environmental factors and highlight the need to promote employee resilience and well-being during times of crisis. Recommendations on how managers can support employees during this unprecedented global health crisis are provided.
Changes in the prairie–forest ecotone in northwest Ontario (Canada) across the Holocene
Authors: Danesh Donya C. , Gushulak Cale A.C. , Moos Melissa T. , Karmakar Moumita , Cumming Brian F.
Published: October 2021

Pollen and diatom assemblages from well-dated sediment cores from three lakes forming a west-to-east transect across the boreal forest in northwest Ontario (Canada) were used to evaluate the timing and nature of the movement of the prairie–forest ecotone (PFE) across the Holocene. Changes in vegetation, temperature, and effective moisture were inferred from pollen and pollen-based transfer functions. Analyses indicated site-specific vegetational and climate changes across short spatial distances, with prolonged prairie-like conditions during the middle Holocene at the westernmost site. Increased reconstructed temperatures at this westernmost site occurred from ~9000 to 3000 cal yr BP, alongside increases in diatom-inferred lake levels beginning at ~6000 cal yr BP. The abundance of Quercus peaked concurrently with rising lake levels before declining to trace levels by ~3000 cal yr BP. Increases in the abundance of non-arboreal pollen between ~8500 and ~4500 cal yr BP at the more eastern lakes suggest relatively delayed and truncated PFE influence, before the reestablishment of primarily boreal taxa by ~4500 cal yr BP, coincident with diatom-inferred increases in lake levels. This study shows that the PFE moved both farther east and north than previously determined, but generally agrees with established patterns in vegetation from other studied regions along the PFE.
Effects of a digital reminiscing intervention on people with dementia and their care-givers and relatives
Authors: Derbring Sandra , Barbos Nordström Melissa , Svenningsson Jenny-Ann , Ekström Anna , Ingebrand Elias , Samuelsson Christina , Laakso Katja , Buchholz Margret
Published: October 2021

Dementia is a source of growing concern globally, and often impacts on social and communicative functioning. INdependent LIving Support Functions for the Elderly (IN LIFE) was a project carried out within the European Commission Research and Innovation programme Horizon 2020 that resulted in the development of two digital communication aids for reminiscence intervention for elderly people with dementia and their communication partners. The purpose of this intervention study was to investigate the effects on quality of life for people with dementia when using these aids. People with dementia (N = 118) and their formal care-givers (N = 187) and relatives (N = 9) were given the communication aids for a period of 4–12 weeks. To assess a range of outcomes, questionnaires developed within the project were used along with the EQ-5D (European Quality of Life – 5 Dimensions) and QoL-AD (Quality of Life in Alzheimer's Disease) questionnaires. Quality of life improved among people with dementia when measured using EQ-5D (p < 0.05). There was also a correlation between the impact on the participants’ health and wellbeing, the carers’ rating of the usefulness of the digital communication aids and the care-givers’ satisfaction with using technology (p < 0.05). These results indicate that digital communication aids may be useful in social interaction where one partner has dementia.
Salmonella illness outbreaks linked to backyard poultry purchasing during the COVID-19 pandemic: United States, 2020
Authors: Nichols Megin , Gollarza Lauren , Palacios Alexandra , Stapleton G. Sean , Basler Colin , Hoff Connor , Low Mabel , McFadden Kenai , Koski Lia , Leeper Molly , Brandenburg Joshua , Tolar Beth
Published: October 2021

Poultry contact is a risk factor for zoonotic transmission of non-typhoidal Salmonella spp. Salmonella illness outbreaks in the United States are identified by PulseNet, the national laboratory network for enteric disease surveillance. During 2020, PulseNet observed a 25% decline in the number of Salmonella clinical isolates uploaded by state and local health departments. However, 1722 outbreak-associated Salmonella illnesses resulting from 12 Salmonella serotypes were linked to contact with privately owned poultry, an increase from all previous years. This report highlights the need for continued efforts to prevent backyard poultry-associated outbreaks of Salmonella as ownership increases in the United States.
“When the Music’s Over” then “Dancing with a Partner Will Help You Find the Beat”
Authors: Gillett Grant , Butler Mary
Published: October 2021

Responses to brain injury sit in the intersection between neuroscience and an ethic of care, and require sensitive and dynamic indicators of how an individual with brain injury can learn how to live in the context of a changing environment and multiple timescales. Therapeutic relationships and rhythms underpinning such a dynamic approach are currently obscured by existing models of brain function. Something older is required and we put forward narrative types articulating outcomes of brain injury over various periods and starting points in time. Such storytelling challenges a static neuropsychological paradigm and moves from an ethics that focuses on patient autonomy into one that is reflective of the cognitive supports and therapeutic relationships that underpin ways that the patient can re-find the beat that proves the music is not over.
Goldwater After Trump
Authors: Appel Jacob M. , Michels-Gualtieri Akaela
Published: October 2021

The “Goldwater rule,” a policy adopted by the American Psychiatry Association (APA) in 1973, prohibits organization members from diagnosing or offering professional opinions regarding the mental health of public figures without both first-hand evaluation and authorization. Initially developed in response to a controversial survey of APA members during the 1964 Presidential election campaign, the ethics rule faced few large scale challenges until the election of Donald Trump in 2016. Since that time, a significant number of psychiatrists have either violated or criticized the rule openly. This paper argues that whatever the initial merits of the rule, the prohibition has since been rendered obsolete by the combined lack of professional consensus supporting the policy, absence of a meaningful enforcement mechanism, and the credible statements of non-APA members in the mental health professions regarding public figures.
Comparison of Unmanned Aerial Vehicle Technology versus Standard Practice of Scene Assessment by Paramedic Students of a Mass-Gathering Event
Authors: Jain Trevor , Sibley Aaron , Stryhn Henrik , Lund Adam , Hubloue Ives
Published: October 2021

Introduction:

The proliferation of unmanned aerial vehicle (UAV) technology has the potential to change the situational awareness of medical incident commanders’ (ICs’) scene assessment of mass gatherings. Mass gatherings occur frequently and the potential for injury at these events is considered higher than the general population. These events have generated mass-casualty incidents (MCIs) in the past. The aim of this study was to compare UAV technology to standard practice (SP) in scene assessment using paramedic students during a mass-gathering event (MGE).

Methods:

This study was conducted in two phases. Phase One consisted of validation of the videos and accompanying data collection tool. Phase One was completed by 11 experienced paramedics from a provincial Emergency Medical Services (EMS) service. Phase Two was a randomized comparison with 47 paramedic students from the Holland College Paramedicine Program (Charlottetown, Prince Edward Island, Canada) of the two scene assessment systems. For Phase Two, the paramedic students were randomized into a UAV or a SP group. The data collection tool consisted of two board categories: primary importance with 20 variables and secondary importance with 25 variables. After a brief narrative, participants were either shown UAV footage or the ground footage depending on their study group. After completion of the videos, study participants completed the data collection tool.

Results:

The Phase One validation showed good consensus in answers to most questions (average 79%; range 55%-100%). For Phase Two, a Fisher’s exact test was used to compare each variable from the UAV and SP groups using a P value of .05. Phase Two demonstrated a significant difference between the SP and UAV groups in four of 20 primary variables. Additionally, significant differences were found for seven out of 25 secondary variables.

Conclusion:

This study demonstrated the accurate, safe, and feasible use of a UAV as a tool for scene assessment by paramedic students at an MGE. No observed statistical difference was noted in a majority of both primary and secondary variables using a UAV for scene assessment versus SP.
How does English national end-of-life care policy impact on the experience of older people at the end of life? Findings from a realist evaluation
Authors: Barker Rhiannon , Wilson Patricia , Butler Claire
Published: October 2021

Aim:

To explore the extent to which national policy in end-of-life care (EOLC) in England influences and guides local practice, helping to ensure that care for older people at the EOL is of a consistently good quality.

Background:

Whilst policy is recognised as an important component in determining the effectiveness of EOLC, there is scant literature which attempts to interrogate how this happens or to hypothesise the mechanisms linking policy to better outcomes.

Method:

This article reports on the second phase of a realist evaluation comprising three case studies of clinical commissioning groups, including 98 in-depth interviews with stakeholders, meeting observation and documentary analysis.

Findings:

This study reveals the key contextual factors which need to be in place at micro, meso and macro levels if good quality EOLC for older people is to be achieved. The findings provide insight into rising local inequalities and reveal areas of dissonance between stakeholder priorities. Whilst patients privilege the importance of receiving care and compassion in familiar surroundings at EOL, there remains a clear tension between this and the medical drive to cure disease and extend life. The apparent devaluing of social care and subsequent lack of resource has impacted significantly on the way in which dying is experienced.

Patient experience at EOL, shaped by the care received both formally and informally, is driven by a fragmented health and social care system. Whilst the importance of system integration appears to have been recognised, significant challenges remain in terms of shaping policy to adequately reflect this. This study highlights the priority attached by patients and their families to the social and relational aspect of death and dying and shines a light on the stark disparities between the health and social care systems which became even more evident at the height of the Covid-19 pandemic.
Effects of herbicide management practices on the weed density and richness in 2,4-D-resistant cropping systems in Indiana
Authors: Hodgskiss Connor L. , Legleiter Travis R. , Young Bryan G. , Johnson William G.
Published: October 2021

Commercialization of 2,4-D-resistant soybean varieties allows for postemergence (POST) applications of 2,4-D in soybean. With the increase in POST applications of 2,4-D in soybean, shifts in weed populations may occur. A long-term field trial was conducted over 7 yr in a corn-soybean rotation. Weed populations were subjected to four herbicide strategies with variable levels of 2,4-D reliance. The strategies used included 1) diversified glyphosate strategy with six herbicide sites of action (SOAs); 2) 2,4-D reliant strategy with three SOAs; 3) diversified 2,4-D reliant strategy with seven SOAs; and 4) fully diversified strategy with eight SOAs. Soil residual herbicides were used for both corn and soybean years, except for the 2,4-D-reliant strategy, which used only a residual herbicide during the corn years. A 52% or greater reduction in weed densities for all herbicide strategies, except the 2,4-D-reliant strategy, was observed by the end of the study. However, the density of weeds tolerant to 2,4-D, such as monocots, increased after 3 yr of selection pressure, and more than doubled after 5 yr of selection pressure in the 2,4-D-reliant strategy. Additionally, in the 2,4-D-reliant strategy with three SOAs, species richness was 30% higher in the soil seedbank compared to herbicides strategies with six or more SOAs. In order to delay weed shifts, diversified herbicide strategies with more than three SOAs that include residual herbicides should be used in corn:soybean rotational systems that use 2,4-D-resistant soybean.
Typ-2-Asthma: Die Perspektive der 1970er Jahre hinter uns lassen
Authors: Rothe Thomas , Latshang Tsogyal Daniela
Published: October 2021

Zusammenfassung. Die Diagnose «Asthma bronchiale» überspannt schirmartig verschiedene Phänotypen dieses Krankheitsbildes. Die Differenzierung dieser Phänotypen und ihrer Overlaps wird immer wichtiger, da heute Phänotyp-spezifische Behandlungsansätze existieren, die nicht bei jeder Asthmaform Wirkung zeigen. Dazu gehören die Strategie der gezielten Allergenkarenz, die Allergen-Immuntherapie und vor allem auch die neu zur Verfügung stehenden Biologika für Asthma. Behandelbare Krankheitsmuster, sogenannte «Treatable Traits», erfordern eine gezielte Diagnostik. Das notwenige Wissen, um diese Merkmale identifizieren zu können, muss sich in der Praxis noch etablieren.
Empfehlungen für die Diagnostik und Therapie psychotischer Erkrankungen im Alter
Authors: Klöppel Stefan , Savaskan Egemen , Annoni Jean-Marie , Berruex Jean-Luc , Bohli Livia , Eder Maria , Hemmeter Ulrich , Hirsbrunner Therese , Leyhe Thomas , Neyenhuys Annetta , Popp Julius , Rauen Katrin , Schuster Jean-Pierre , Sulaj Vita , Vögeli Samuel , Gunten Armin von , Zavorotnyy Maxim , Zullo Leonardo , Roth Fabienne , Lötscher Claudia
Published: October 2021

Zusammenfassung. Psychotische Erkrankungen im Alter umfassen ein grosses Spektrum an Ursachen und Manifestationen. Häufig treten sie im Rahmen einer Depression, einer demenziellen Entwicklung, eines Substanz- und Medikamentenmissbrauchs oder eines Delirs auf. Während im Alter neue Erkrankungen auftreten können, erreichen zunehmend auch mehr Personen mit langjährig bestehenden, chronisch psychotischen Störungen das höhere Lebensalter. Neben psychotischen Störungen sind im Alter kognitive und somatische Beeinträchtigungen häufig, weshalb eine Fremdanamnese unverzichtbar ist. Die krankheitsbedingt veränderten Lebensumstände, die Komplexität und die jeweils individuelle Situation gilt es bei der Diagnostik und Therapie zu integrieren. Die vorliegenden Empfehlungen sind unter der Federführung der Schweizerischen Gesellschaft für Alterspsychiatrie und -psychotherapie (SGAP) in Zusammenarbeit mit den akademischen Fachgesellschaften für gerontologische und psychiatrische Pflege des Vereins für Pflegewissenschaft und weiteren Fachverbänden entstanden. Ziel ist es, den aktuellen Stand des Wissens über die psychotischen Erkrankungen im Alter sowie über die Möglichkeiten der Diagnostik und Therapie zusammenzufassen und den interprofessionellen, klinischen Teams in der stationären und ambulanten Versorgung zur Verfügung zu stellen.
Attention Network Forecasts Time‐to‐Failure in Laboratory Shear Experiments
Authors: Jasperson Hope , Bolton David C. , Johnson Paul , Guyer Robert , Marone Chris , de Hoop Maarten V.
Published: October 2021

Rocks under stress deform by creep mechanisms that include formation and slip on small‐scale internal cracks. Intragranular cracks and slip along grain contacts release energy as elastic waves termed acoustic emissions (AE). AEs are thought to contain predictive information that can be used for fault failure forecasting. Here, we present a method using unsupervised classification and an attention network to forecast labquakes using AE waveform features. Our data were generated in a laboratory setting using a biaxial shearing device with granular fault gouge intended to mimic the conditions of tectonic faults. Here, we analyzed the temporal evolution of AEs generated throughout several hundred laboratory earthquake cycles. We used a Conscience Self‐Organizing Map (CSOM) to perform topologically ordered vector quantization based on waveform properties. The resulting map was used to interactively cluster AEs. We examined the clusters over time to identify those with predictive ability. Finally, we used a variety of LSTM and attention‐based networks to test the predictive power of the AE clusters. By tracking cumulative waveform features over the seismic cycle, the network is able to forecast the time‐to‐failure (TTF) of lab earthquakes. Our results show that analyzing the data to isolate predictive signals and using a more sophisticated network architecture are key to robustly forecasting labquakes. In the future, this method could be applied on tectonic faults to monitor earthquakes and augment early warning systems.
Radiocarbon Analyses Quantify Peat Carbon Losses With Increasing Temperature in a Whole Ecosystem Warming Experiment
Authors: Wilson Rachel M. , Griffiths Natalie A. , Visser Ate , McFarlane Karis J. , Sebestyen Stephen D. , Oleheiser Keith C. , Bosman Samantha , Hopple Anya M. , Tfaily Malak M. , Kolka Randall K. , Hanson Paul J. , Kostka Joel E. , Bridgham Scott D. , Keller Jason K. , Chanton Jeffrey P.
Published: October 2021

Climate warming is expected to accelerate peatland degradation and release rates of carbon dioxide (CO2) and methane (CH4). Spruce and Peatlands Responses Under Changing Environments is an ecosystem‐scale climate manipulation experiment, designed to examine peatland ecosystem response to climate forcings. We examined whether heating up to +9 °C to 3 m‐deep in a peat bog over a 7‐year period led to higher C turnover and CO2 and CH4 emissions, by measuring 14C of solid peat, dissolved organic carbon (DOC), CH4, and dissolved CO2 (DIC). DOC, a major substrate for heterotrophic respiration, increased significantly with warming. There was no 7‐year trend in the DI14 C of the ambient plots which remained similar to their DO14 C. At +6.75 °C and +9 °C, the 14C of DIC, a product of microbial respiration, initially resembled ambient plots but became more depleted over 7 years of warming. We attributed the shifts in DI14 C to the increasing importance of solid phase peat as a substrate for microbial respiration and quantified this shift via the radiocarbon mass balance. The mass‐balance model revealed increases in peat‐supported respiration of the catotelm depths in heated plots over time and relative to ambient enclosures, from a baseline of 20%–25% in ambient enclosures, to 35%–40% in the heated plots. We find that warming stimulates microorganisms to respire ancient peat C, deposited under prior climate (cooler) conditions. This apparent destabilization of the large peat C reservoir has implications for peatland‐climate feedbacks especially if the balance of the peatland is tipped from net C sink to C source.