bluuebunny/crossref_metadata_2025 huggingface dataset:
deepBreaks: a Machine Learning Tool for Identifying and Prioritizing Genotype-phenotype Associations
Authors: Baghbanzadeh Mahdi , Dawson Tyson , Sayoldin Bahar , Oakley Todd , Crandall Keith , Rahnavard Ali
Published: February 2023

Sequence data (e.g., nucleotides or amino-acids) are critical for advancing our understanding of biology. However, there are many challenges with investigating and analyzing sequencing data and genotype-phenotype associations, including non-independent observations, large noise components, nonlinearity, colinearity, and high dimensionality. Therefore, machine learning (ML) algorithms are well suited for analyzing sequence data as they can capture nonstructural patterns of relationships with the biology of interest as genotype-phenotype associations. Nevertheless, flexible and user-friendly implementations of ML approaches are lacking, especially ones that take advantage of the unique features of high-volume DNA sequence data. Here, we present deepBreaks, a generic approach with unified data analysis steps that identify the most important positions in sequence data that correlate with phenotypic traits of interest. deepBreaks compares the performance of multiple ML algorithms and prioritizes the most important positions based on the best-fit models. deepBreaks is open-source software with documentation available online at https://github.com/omicsEye/deepBreaks.
Factors Associated With Prolonged Pauses Between Chest Compressions in RCP With POCUS
Authors: Filho Carlos Alberto de Melo
Published: February 2023

Introduction: Point-of-care ultrasound (POCUS) is recommended for use in cardiopulmonary resuscitation (CPR) when reversible causes are suspected. However, studies have shown that POCUS can increase the time of pauses between compressions, in which pulse and rhythm are verified.
Objective: To describe possible factors associated with longer pauses between chest compressions with the use of POCUS.
Methodology: Methodology: Literature review in PubMed, Embase, Scopus and Biblioteca Virtual em Saúde (BVSaúde) databases. The search was performed without time or language restriction, using the following strategy: ((arrest, cardiopulmonary OR cardiopulmonary resuscitation OR Advanced Cardiac Life Support) AND (point of care ultrasound OR POCUS)).
Results and discussion: The database search resulted in 6177 publications. Of these, only five studies were included. Lack of ultrasound training is associated with longer pauses by approximately 3.1 seconds (95% CI 0.6-5.6; p-value= 0.02). Operating the POCUS and leading CPR at the same time was associated with a delay of up to 6.1 seconds (95% CI 0.4-11.7; p-value= 0.04). In addition, the time to place the ultrasound probe on the patient's chest and the lack of a systematization for POCUS use may also contribute to longer pauses.
Final thoughts: It is hoped that this discussion will spark interest in further research on the topic, as well as be used to devise new protocols for the use of POCUS in CPR to circumvent the limitations described.
Abstracts of AICTE Sponsored International Conference on Post-COVID Symptoms and Complications in Health
Authors: Kumar Vivek
Published: February 2023

This book presents the selected abstracts of the International Conference on Post-COVID Symptoms and Complications in Health, hosted from the 28th to 29th of April 2022 in virtual mode by the LR Institute of Pharmacy, Solan (H.P.)-173223 in Collaboration with AICTE, New Delhi. This conference focuses on the implications of long-term symptoms on public health, ways to mitigate these complications, improve understanding of the disease process in COVID-19 patients, use of computational methods and artificial intelligence in predicting complications, and the role of various drug delivery systems in combating the complications.
Equal-time approach to real-time dynamics of quantum fields
Authors: Ott Robert , Zache Torsten V. , Berges Jürgen
Published: February 2023

We employ the equal-time formulation of quantum field theory to
derive effective kinetic theories, first for a weakly coupled
non-relativistic Bose gas, and then for a strongly correlated system of
self-interacting NN-component
fields. Our results provide the link between state-of-the-art
measurements of equal-time effective actions using quantum simulator
platforms, as employed in [Phys. Rev. X 10, 011020 (2020); Nat. Phys.
16, 1012 (2020)], and observables underlying effective kinetic or
hydrodynamic descriptions. New non-perturbative approximation schemes
can be developed and certified this way, where the a priori time-local
formulation of the equal-time effective action has crucial advantages
over the conventional closed-time-path approach which is non-local in
time.
Covid-19 Psycho-social Impact among United Nations Staff in Burundi
Authors: Musengimana Jean Claude
Published: February 2023

The coronavirus (Covid-19) is a pandemic that threatens many people’s lives. The objective of this study was to explore the Covid-19 psycho-social impact on Staff working in the United Nations in Burundi from October 2021 to 31st January 2022. This was a cross-sectional study involving 312 study participants. Univariate and bivariate analysis were processed using SPSS 25, and the Chi-square test was calculated with a p<0.05. As a result, all psycho-social components assessed were affected by Covid-19. The Staff experienced a very high level of psycho-social impact (very severe) which varied from 31% for being afraid of financial problems and unhappiness due to missing professional support from colleagues to 47% for being afraid of a family member infected by Covid-19. Also, we assessed their particularity of psycho-social impact due to the exposure of being clinical or non-clinical Staff, whereby, clinical Staff had a lower risk of being affected compared to the non-clinical Staff in some components. For instance, clinical Staff was 0.39 times more affected by fear of being infected by Covid-19 compared to non-clinical Staff (CI= (0.23,0.65). Also, there are some components where the impacts were similar for clinical and non-clinical Staff (Chi-square test p-value > 0.05 and CI of odds ratios cross 1). Thus, UN employees were negatively affected by Covid-19 from a psycho-social standpoint. The study recommends UN agencies in Burundi support staff by providing emergency psychological support and, if required to give medical treatment for job optimization. Hence, staff psycho-social status must be constantly checked and kept stable. Keywords: Covid-19, Impact, Psycho-social, Staff, United Nations.
Removal of endocrine-disrupting chemical mixtures in water using chlorination and photolysis
Authors: Azevedo Taiza dos Santos , Santos Juliana Palermo Evangelista dos , Monteiro Neto João , Gomes Fernanda Bento Rosa , Bottrel Sue Ellen Costa , Mounteer Ann Honor , Pereira Renata de Oliveira
Published: February 2023

Micropollutants have been continuously detected in freshwater. In parallel, the potential adverse effects of human exposure to endocrine-disrupting chemicals (EDCs) through drinking water have been gaining the attention of researchers and health authorities. Given this fact, this study aimed to evaluate the effectiveness of chlorination and photolysis to remove the estrogenic activity caused by mixtures of EDCs in water: estrone (E1: 100 ng L−1), 17β-estradiol (E2: 100 ng L−1), ethinylestradiol (EE2: 50 ng L−1), and nonylphenol (NP: 1,000 ng L−1) under operating conditions applicable for water treatment plants. The tests were performed using freshwater spiked with the following mixtures: E1 + E2, E1 + E2 + EE2, E1 + E2 + NP, and E1 + E2 + EE2 + NP). Removal efficiencies of up to 99.7% were achieved at a chlorine dose of 2.75 mg L–1 and 30 min of contact time. In photolysis, estrogenic activity removal was higher than 99.9% at a UV dose of 186 mJ cm–2. Results indicated that both chlorination and photolysis can be efficient to remove the estrogenic activity caused by the tested EDC mixtures in water. Furthermore, experiments suggested that EDC mixtures can be efficiently removed at feasible water disinfection operating conditions.
Психологические детерминанты адаптированности в вузе студентов-первокурсников медицинского факультета в период пандемии COVID-19
Authors: Гнедых Дарья С. , Тихомирова Марина А. , Яковлева Мария В.
Published: February 2023

Введение. Успешная адаптация студентов в университете обуславливает вовлеченность в учебную деятельность, ее эффективность, положительное отношение к выбранной профессии. Новизной исследования является изучение адаптированности студентов в ситуации перехода на новые, зачастую непривычные, формы обучения (онлайн, дистанционная) на фоне повышения общего уровня тревожности в период пандемии COVID-19. Такие трудности особенно затронули студентов медицинских специальностей, освоение которых подразумевает формирование компетенций в практической деятельности. Методы. В исследовании приняли участие студенты медицинского (N = 93) и экономического (контрольная группа, N = 111) факультетов. Были использованы следующие методики: «Адаптированность студентов в вузе» Т. Д. Дубовицкой, А. В. Крыловой, «Удовлетворенность жизнью» Э. Динера, «Тест нервно-психической адаптации» И. Н. Гурвича, «Учебные стратегии» С. Н. Костроминой, Т. А. Дворниковой, «Методика для диагностики учебной мотивации студентов» Н. Ц. Бадмаевой, «Большая пятерка» Д. П. Яничева, «Интегративный тест тревожности» А. П. Бизюка с соавт. (2 часть). Результаты и их обсуждение. К психологическим особенностям студентов первого курса медицинского факультета, способствующим адаптированности в вузе в период пандемии COVID-19, относятся: высокий уровень экстраверсии, готовность к сотрудничеству, наличие профессиональных мотивов учебной деятельности и мотивации достижения успеха, высокий уровень нервно-психической адаптации, ориентация на запоминание учебного материала и несклонность к планированию учебной деятельности. У студентов экономического факультета – это удовлетворенность жизнью, высокий уровень экстраверсии, низкий уровень тревожности, мотивы творческой самореализации и стремление к планированию в обучении. Студенты медицинского факультета с высоким уровнем адаптированности, по сравнению с высоко адаптированными студентами экономического факультета, имеют более выраженные профессиональные мотивы и чаще прибегают к стратегии повторения учебного материала. Такие различия могут быть обусловлены как особенностями организации образовательного процесса, так и спецификой выбранной специальности.
Arginine-Glycine-Aspartic Acid-anchored Curcumin-based Nanotherapeutics
Inhibit Pyroptosis-induced Cytokine Release Syndrome for In Vivo and In Vitro
Sepsis Applications
Authors: Xu Xiao-Ling , Chen Wei , Shi Yi , Wu Qian , Lu Yi , Meng Ling-Peng , Wang Xiao-Juan
Published: February 2023

Aim:

We aimed to design RGD-anchored liposomes encapsulating an antipyroptosis drug that could efficiently target macrophages and relieve the rate of cytokine release syndrome, providing a new strategy for sepsis treatment, especially sepsis-induced acute renal injury.

Background:

Sepsis is a clinical syndrome of life-threatening organ dysfunction caused by host response disorders due to infection. Sepsis has a high incidence and remains one of the leading causes of death worldwide.

Objective:

Macrophage-mediated pyroptosis plays an important role in the occurrence and development of cytokine release syndrome and organ injury caused by sepsis. Curcumin can inhibit inflammasome assembly and slow the progression of pyroptosis by scavenging intracellular reactive oxygen species, but it has poor water solubility and low bioavailability. The emergence of drug-delivery nanosystems has overcome this problem, but there is still a lack of research on how to accurately deliver antipyroptotic drugs to innate immune cells and subsequently hinder pyroptosis.

Method:

We constructed a curcumin-loaded RGD-modified liposome (RGD-lipo/Cur) and demonstrated that RGD-lipo/Cur could effectively target macrophages.

Result:

In vitro, RGD-lipo/Cur reduced the upregulation of caspase-1, caspase-3, NLRP3, IL-1β and GSDMD, inhibiting pyroptosis, reducing oxidative stress, and attenuating the proinflammatory cytokine cascade.

Conclusion:

RGD-lipo/Cur was considered to have great potential for sepsis treatment.
Genus Knema: An Extensive Review on Traditional Uses, Phytochemistry,
and Pharmacology
Authors: Hop Nguyen Quang , Son Ninh The
Published: February 2023

Background:

Knema (the Myristicaceae family) is a large genus of small-medium trees
found in Southeast Asia, Africa, and Australia. Historical records dealt with the uses of Knema
species as medicinal plants against various diseases, especially cancer remedies, or their application
as tonic agents in Asian communities

Objective:

The aim of this review is to provide the most current knowledge on the traditional uses,
chemical profiles, as well as pharmacological values of Knema plants.

Methods:

Through electronic search, the literature materials on Knema plants were acquired from
scholarly journals, books, and internationally recognized scientific databases, such as PubMed,
ScienceDirect, Sci-Finder, Web of Science, and Google Scholar. All full-text articles and abstracts
on Knema were screened. Genus Knema, traditional use, phytochemistry, and pharmacology were
the first selective keywords to search for references.

Results:

Since the 1970s, more than 185 metabolites have been isolated from Knema plants and
structurally elucidated. Among them, phenolic lipids, flavonoids, and lignans are the principal
metabolites. Crude extracts, fractions, and isolated compounds of Knema species possess a wide
variety of pharmacological properties, such as antioxidative, antidiabetic, antimicrobial, antiinflammatory,
antimalarial, neuroprotective, and hepatoprotective activities, but cytotoxicity is the
most striking feature. Phenolic lipids containing long alkyl side chains and polar hydroxyl or acyl
groups are found as the most active molecules in cytotoxic assays.

Conclusion:

Further studies on phytochemistry and pharmacological activities, toxicological assessments,
pharmacological mechanisms, and pharmacokinetics are urgently needed.
Therapeutic Monoclonal Antibodies for Non-Hodgkin Lymphoma: A
Literature Review
Authors: Fallahi Mohammad Sadegh , Zerangian Nasibeh , Ghorbani Atousa , Erabi Gisou , Shirali Melika , Shabani Elaheh , Rommasi Foad , Najafabadi Mahsa Mohammadi , Karbasi Shima , Toutounchian Samaneh , Ahangar-Sirous Ramin , Motaghy Ava , Heidari Mahsa , Deravi Niloofar
Published: February 2023

Non-Hodgkin lymphoma (NHL) occurs in the lymphatic system because of lymphocytes tumor. This type of tumor has a high death rate among patients. In recent years, a lot of progress has been made based on understanding its exact biology; several treatment methods have been developed. Many patients are cured by a combination of different chemotherapies, despite their toxic effects. In recent years, despite various studies on monoclonal antibodies for non-Hodgkin lymphoma, there have been no narrative articles in this field. Therefore, combining monoclonal antibodies with chemotherapy is successful as they reduce the toxic side effects of chemotherapies. These antibodies can target specif-ic cellular pathways of the immune system leading to limitation of cancer progression. In this article, various types of monoclonal antibodies, their underlying mechanisms of action, as well as their effects on patients with different phases and types of Non-Hodgkin lymphoma have been reviewed for a better understanding.
SPOR BİLİMLERİ FAKÜLTESİNDEKİ ÖĞRENCİLERİN LİDERLİK ÖZELLİKLERİNİN İNCELENMESİ
Authors: Özçetin Serdar , Atalay Hakan
Published: February 2023

Bu araştırmanın amacı; öğrencilerin liderlik özelliklerinin düzeyini belirlemek ve cinsiyete, okuduğu bölüme, sınıfa göre karşılaştırmaktır. Araştırmada nicel araştırma yöntemlerinden betimsel model benimsenmiştir. Araştırmanın evrenini 2018–2019 eğitim-öğretim yılında Akdeniz Üniversitesi Spor Bilimleri Fakültesindeki öğrenciler oluşturmaktadır. Örneklemi ise basit seçkisiz (olasılıklı) örnekleme yöntemi kullanılarak belirlenen 217 öğrenci oluşmaktadır. Araştırmada, Cansoy, Türkoğlu ve Parlar (2016) tarafından geliştirilen “Liderlik Özellikleri Ölçeği” veri toplama aracı olarak kullanılmıştır. Veri toplama aracı, 6 alt boyutta [Özgüven (8 madde), Grupla Çalışma (7 madde), Güvenilir Olma (5 madde), İkna Yeteneği (3 madde), Problem Çözebilme (3 madde) ve Sorumluluk (2 madde)] 28 maddeden oluşan 5’li likert tipi bir ölçektir. Bu araştırmada liderlik özellikleri ölçeğinin tümü için Cronbach alfa güvenirlik katsayısı .85 olarak bulunmuştur. Verilerin analizinde frekans, yüzde, aritmetik ortalama, standart sapma, bağımsız örneklemler için t-testi ve ANOVA analizleri uygulanmıştır. Araştırmanın sonucunda; öğrencilerin liderlik düzeylerinin yüksek olduğu sonucuna ulaşılmıştır. Cinsiyete göre yapılan karşılaştırmada güvenilir olma ve sorumluluk boyutlarında kadınların erkeklere göre daha yüksek düzeyde olduğu sonucuna ulaşılmıştır. Öğrencilerin liderlik özellikleri bölümlerine göre karşılaştırıldığında grupla çalışabilme ve güvenilir olma boyutlarında spor yöneticiliği bölümündeki öğrencilerin antrenörlük bölümündeki öğrencilere göre daha yüksek sevide olduğu sonucuna ulaşılmıştır. Sınıflara göre yapılan karşılaştırma sonucunda; 4.sınıfların 1.sınıflara göre daha yüksek özgüvene, ikna yeteneğine ve sorumluluğa sahip olduğu sonucuna ulaşılmıştır.
On the Relationship Between Teacher Stress, Student Age, and Social-Emotional Competence
Authors: Junker Robin
Published: February 2023

Stress in teaching leads to many teachers suffering from burnout or leaving the profession. Therefore, it is important to identify specific correlates of teacher stress. The role of student age and social-emotional competence in teacher stress emergence is still unclear To further clarify this relationship, 284 teachers were surveyed using a questionnaire that measured teacher stress, student year grade, and student social-emotional competence. Results show a strong negative relationship between grade level and teacher stress and a positive relationship between variance in students’ social-emotional competence and teacher stress. Social-emotional competence did not mediate between student year grades and teacher stress. Directions for further research and practical implications for teacher education are discussed.
Exposure to Pornography and Adolescent Sexual Behavior: Systematic Review
Authors: Pathmendra Pranujan , Raggatt Michelle , Lim Megan SC , Marino Jennifer L , Skinner S Rachel
Published: February 2023

Background

Formative experiences in adolescence lay the foundation for healthy and pleasurable romantic and sexual relationships. Exposure to pornography may affect these experiences.

Objective

We aimed to synthesize evidence published in the past decade on the relationship between exposure to pornography and sexual behavior (earlier age of first sex [<16 years], condomless sex, past-year multiple partners [>1], lifetime multiple partners [>1], group sex, sexual aggression including forced sex, paid sex, teenage pregnancy, and history of sexually transmitted infection) in adolescents aged between 10 and 19 years.

Methods

We identified 19 eligible studies by searching MEDLINE, PsycINFO, Cochrane, CINAHL, Embase, and Web of Science databases from January 2010 to November 2022.

Results

Out of 8 studies that assessed earlier age of first sex, 5 studies, including 1 longitudinal study, found a statistically significant association with exposure to pornography. Given that most studies were cross-sectional or had substantial limitations, causal inference could not be made. Also, exposure to pornography was not measured consistently. The evidence was conflicting or insufficient to draw any conclusions regarding other outcomes.

Conclusions

More quantitative research is needed to elucidate the association between pornography exposure and sexual behavior, and sex education should adopt evidence-based approaches to minimize the potential harms from pornography.

Trial Registration

PROSPERO International Prospective Register of Systematic Reviews CRD42021227390; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=227390
Inclusion of Participants with CKD and Other Kidney-Related Considerations during Clinical Drug Development
Authors: Butrovich Morgan A. , Reaves Allison C. , Heyward Jamie , Moore Thomas J. , Alexander G. Caleb , Inker Lesley A. , Nolin Thomas D.
Published: February 2023

Background

The US Food and Drug Administration has prioritized efforts to expand availability of therapies, including anticancer agents, for patients with CKD. US Food and Drug Administration Guidance recommends inclusion of study participants with CKD in clinical trials, improving pharmacokinetic characterization in people with decreased GFR, and using contemporary GFR assessment methods during drug development. We performed a landscape analysis of anticancer agents approved from 2015 to 2019 to evaluate inclusion of study participants with CKD and GFR assessment methods used during drug development and subsequent translation to kidney-related safety and dosing data in product labeling.

Methods

Oncology drugs approved from 2015 to 2019 and associated pivotal trials were identified. We evaluated inclusion of study participants with CKD in pivotal trials and pharmacokinetic analyses, investigated GFR assessment methods used for pivotal trial eligibility and renal pharmacokinetic analyses, and identified kidney-related adverse drug event and dosing information.

Results

A total of 55 drugs and 74 pivotal trials were included. Of the pivotal trials, 95% contained kidney-related eligibility criteria, including 68% with GFR-based eligibility. The median lower limit of GFR required for inclusion was 45 ml/min or ml/min per 1.73 m2. Pharmacokinetic analyses were performed in CKD stages 4–5 and hemodialysis for only 29% and 6% of drugs, respectively. Estimated creatinine clearance was used in over 60% and 80% of pivotal trials and pharmacokinetic analyses, respectively. Reporting of kidney-related adverse drug events was highly variable. Product labeling for 49% of drugs contained no kidney dosing information.

Conclusions

Study participants with CKD continue to be excluded from anticancer drug development, and GFR estimation in pivotal trials and renal pharmacokinetic analyses remains imprecise and heterogeneous. Furthermore, kidney-related safety and dosing information is scarcely and inconsistently presented.
Study on the Design of Writing Activities for the Integrative Review of High School English Units Based on the “Large Unit” Mode
Authors: Shi Xiaomei
Published: February 2023

The “large unit, overall context and major task” teaching mode marks the transformation of English teaching. Under the new situation of cultural conflicts, integration and innovation, the establishment of English learning task groups with English core competence as the guideline and students’ English practice as the focus is an innovative teaching mode to meet the demands of the times, namely “influencing people through culture and cultivating people via learning”. Applying the teaching mode of “large unit, overall context and major task” to the writing teaching can enrich the text contents and imbue teaching with poetic charm. Taking “Cultural Relics: Topic Writing Based on Modular Review” in the reading section in Unit 1 of Oxford High School English Book 2 as an example, this paper introduces how the teacher presents the topic writing method through the examples in the textbook, which takes the textbook as the foundation, focuses on the contents of the whole unit, and transcends the text by secondary processing, and finally generates the materials required in teaching. This method aims to encourage students to learn from words to sentences and then to paragraphs by way of gradation and progress with tiered difficulty. Text processing based on profound understanding strengthens students’ impression and memory, displaying a new teaching perspective for the writing.
A Review on design and analysis of steel bridge with identification of load bearing capacity
Authors: Dharwe Mohini , Prajapati Mohit Kumar
Published: February 2023

Strengthening old bridges is an increasingly relevant strategy for risk prevention and operation continuity in management of infrastructures. Transportation networks are subjected to progressively stricter environmental and load conditions, leading to a growing number of deficient structures, also due to aging and deterioration. However, employable resources are finite, from both economic and environmental points of view. For these reasons, strengthening opportunities should be considered as a viable option, improving bridges with low economic and environmental impact. With this perspective, a selection of some of the most interesting strengthening techniques for old truss steel bridges is presented. To address effective solutions, the most frequent problems in old truss railway bridges are first presented. Literature analysis and experts’ interviews were conducted and compared to results obtained from a representative bridge cluster. Different solutions addressing highlighted problems are then collected and qualitatively evaluated, in terms of efficacy on structural and typical construction requirements. Finally, general remarks and recommendations based on collected evidence are presented.
Jaguar (Panthera onca) food resource use and its interaction with humans: scoping review
Authors: Rubio-Rocha Yamel G. , Gaxiola Soila M. , Chávez Cuahtémoc , Ceballos Gerardo , Bojorquez Cristal , Diaz Daniel
Published: February 2023

A scoping review was conducted to map, summarize, and understand the extent of evidence on jaguar (Panthera onca) food resource use and its interaction with humans. A total of 105 studies were identified in electronic databases: 57 analyzed jaguar food resource use, and 48 described jaguar interactions with humans. The studies were published in 51 journals, mainly in English, from 1993–2021 in 14/19 countries where jaguars live. The evidence demonstrated the variability and prey consumption of the jaguar; there are contrasting results regarding the diversity of prey consumed. The frequency of livestock predation was found to be related to the abundance and availability of natural prey and the distance of ranches from the jaguar habitat. The interaction of the jaguar with humans presented an interesting and contrasting picture, since the perception of the jaguar varied depending on the sociocultural context and the study site. The results showed a negative effect of human activities on the distribution and density of the feline, and there was evidence of poaching and attacks on humans, although the information was insufficient to determine the causes in depth. More research and dissemination are needed on these issues at the local level in the regions where the jaguar lives, as these are the areas where decisions and actions are needed to conserve the jaguar in coexistence with communities and livestock.
A Literature Survey on “Misinformation Flagging System”
Authors: Modi Kritik , Shreshth Shubham , V Karan , Yadav Himanshu , D V Sarala
Published: February 2023

Abstract: Many people rely on social media as their main information source these days. But it has two sides to it. The cheap cost, simple access, and quick information distribution encourage consumers to read news on social media. But it also facilitates the dissemination of incorrect information without any malicious intent and disinformation can go unnoticed. As publishing news online is inexpensive and spreading it through social media is much simpler and faster than through traditional channels, a lot of misinformation is created on the internet for a number of reasons, such as financial benefits and political benefits of many different parties. The ecology of the news industry's authenticity check might be upset by fake news. Consumers are purposefully led to believe inaccurate or biased information via fake news. Propagandists typically use fake news to spread political ideas or exert influence. Some fake news is simply designed to incite people's mistrust and confound them, making it difficult for them to tell what is genuine from what is not.
Factory Monitoring and Alert System
Authors: Sen Arko , Mandal Surajit , Majumdar Ivy , Gupta Agrika , Banerjee Ankit
Published: February 2023

Abstract: The basic idea of our project is to make a Monitoring and Alert System using Embedded Systems and IOT. Our project deals with various kinds of sensors (like temperature sensors, gas sensors, etc.) and other peripherals along with an Arduino UNO Microcontroller and Wi-Fi module. Here all these sensors will collect data from the surrounding, and send it to the Arduino which will further send it to a website and will also send an alert if any sort of unwanted conditions is observed. Monitoring all the sensor data remotely with the help of Arduino UNO via the Internet of Things is the main purpose of our project. We believe that this will provide users with a simple, reliable, and speedy way to monitor a factory remotely and warn people in case of any emergency
Pengembangan Potensi Usaha Masyarakat Untuk Mewujudkan Kemandirian Ekonomi Melalui Transformasi Digital di Desa Sambirata, Kecamatan Cilongok, Kabupaten Banyumas
Authors: Rina Mudjiyanti  , Naelati Tubastuvi  , Rezky Pramurindra  , Sulistyani Budiningsih  , Aji Mukhlis Prasetyo
Published: February 2023

Program pengabdian masyarakat dengan judul Pengembangan Potensi Usaha Masyarakat Untuk Mewujudkan Kemandirian Ekonomi Melalui Transformasi Digital, bertujuan untuk meningkatkan skala usaha BUMDes dan Karang Taruna Desa Sambirata dalam menghadapi tantangan dan peluang usaha di era digital. Permasalahan yang dihadapi oleh mitra adalah, keterbatasan akses internet di desa Sambirata. Kedua  terbatasnya saluran distribusi pemasaran, karena minimnya pengetahuan tentang digital marketing dan minimnya pengetahuan tentang marketplace sebagai platform bisnis online. Ketiga, pengembangan usaha melalui peningkatan kemampuan usaha secara digital. Keempat, peningkatan kemampuan pemasaran digital melalui aplikasi e-commerce. Manfaat yang diperoleh pelaku usaha BUMDes dan Karang Taruna adalah pertama, pemerataan akses internet, kedua peningkatkan literasi digital, ketiga peningkatan kemampuan pengelolaan usaha secara digital dan keempat peningkatan kemampuan pengemasan produk dan pemasaran digital. Perlu adanya effort dan strategi bisnis untuk menyakinkan pelaku usaha dalam menghadapi ketidakpastian masa depan. Kegiatan pengabdian masyarakat mampu meningkatkan skala usaha (scale-up) pelaku ekonomi Desa. Melalui BUMDes dan Karang Taruna, pelaku usaha Desa mulai bertransformasi digital memanfaatkan teknologi dalam pemasaran produk. Google my business digunakan BUMDes Ngudi Makmur sebagai salah satu strategi digital marketing untuk meningkatkan aksesibilitas dan konektivitas dengan masyarakat. Masyarakat semakin mudah untuk memperoleh informasi mengenai produk Kapulaga sebagai komoditi unggulan Desa Sambirata. Hal ini didukung dengan pemerataan akses internet di area Desa Sambirata. Aplikasi e-commerce melalui pasarsambirata.com mampu meningkatkan daya saing produk usaha Desa. Melalui BUMDes dan Karang Taruna, pelaku usaha Desa dapat mempromosikan dan bertransaksi secara online dengan konsumen. Hal ini tentunya dapat meningkatkan pendapatan usaha sehingga diharapkan kemandirian ekonomi desa dapat terwujud.
Dampak Wisata Taman Ghanjaran Terhadap Pendapatan Masyarakat Desa Ketapanrame Kabupaten Mojokerto
Authors: Febriansyah Galvin Arfendo , Nuraini Ida
Published: February 2023

Economics is a field of study on the management of individual, community and state material resources to improve the welfare of human life. Meanwhile, community income is the receipt of remuneration or salary from business results obtained by individuals or groups of households within a certain period of time. For Indonesia, the tourism sector plays an important role in the national economy, both as a source of foreign exchange earners and as a creator of employment and business opportunities. In addition, tourism also has a very important role in development, namely encouraging regional development, increasing national income in order to improve the welfare and prosperity of the people and fostering a sense of love for the homeland, enriching national culture and strengthening its development in order to strengthen national identity and strengthen friendship between nations. This type of research is descriptive quantitative research. The data used in this study were interviews and questionnaires. The sample used was 52 respondents. The research method used to measure income before and after is using the Paired Sample t-Test difference test.The influence of tourism on the income of the people of the village of Ketapanrame shows significant results. The results showed that the influence of Ghanjran Park tourism on increasing people's income was quite effective. This means that there is an increase in people's income after the Ghanjaran park tour than before the Ghanjaran park tour.
Penguatan Ekonomi Masyarakat Pasca Pandemi Covid-19 di Kecamatan Ampelgading Kabupaten Malang
Authors: Hariyani Happy Febrina , Kusuma Hendra
Published: February 2023

Pandemi covid 19 secara umum mengurangi aktifitas masyarakat di sejumlah daerah tidak terkecuali di beberapa desa Tawangagung pada Kecamatan Ampelgading Kabupaten Malang. Kegiatan masyarakat yang sebelumnya dapat dilaksanakan dan berinteraksi dengan daerah lain dengan leluasa harus dikurangi demi keamanan dan Kesehatan masyrakat. Dengan kelebihan sumber daya alam di sekitar wilayah, masyarakat dapat memanfaatkan untuk meningkatkan pendapatan. Pemerintah desa sebagai fasilitator aktifitas masyarakat berperan penting untuk dapat membantu mengembangkan usaha di daerah. Identifikasi awal potensi di daerah menjadi kunci untuk menentukan kebijakan dan bantuan yang akan di berikan. Tahap berikutnya adalah memberikan beberapa pelatihan sesuai dengan karakteristik wilayah seperti Pelatihan kewirausahaan, Pemberian bantuan bibit, Pelatihan budidaya peternakan, Mempromosikan sektor usaha kecil menengah pedesaan melalui teknologi informasi. Di desa Tawangagung sendiri terdapat beberapa usaha kecil yang karakternya sama yaitu peternakan, perkebunan terutama kebun salak dan kopi dan beberapa UMKM pengolahan lainnya. Dengan identifikasi, pendampingan dan bantuan beberapa alat yang bersentuhan langsung dengan usaha masyarakat diharapkan mampu memberikan konstribusi positif bagi pendapatan masyarakat.
Asociación entre calidad del tratamiento endodóntico y periodontitis apical, evaluada mediante Tomografía computarizada de haz cónico en una población colombiana
Authors: Blanco-Fuentes Bibiana Yorley , Moreno-Monsalve Jaime Omar , Mesa-Herrera Uriel
Published: February 2023

Introducción: La prevalencia de periodontitis apical en dientes con tratamiento endodóntico oscila entre el 35 y el 60%, se ha encontrado una fuerte asociación con respecto al grado de inflamación sistémica generada por la periodontitis apical, como por ejemplo altos niveles de citoquinas proinflamatorias, proteína C reactiva e interleuquina 6; estudios refieren que un tratamiento endodóntico adecuado puede reducir los niveles de proteína C reactiva en individuos sanos y con periodontitis apical. Objetivo: Evaluar la frecuencia de periodontitis apical en una población adulta colombiana seleccionada y su correlación con la calidad del tratamiento endodóntico. Materiales y métodos: Estudio observacional analítico de corte transversal, se determinó la frecuencia de periodontitis apical en 318 CBCT (Tomografía computarizada de haz cónico, de pacientes de una subpoblación de Bucaramanga y Medellín y evaluó la asociación de la calidad del tratamiento endodóntico con el estado periapical. Resultados: Sólo el 37,66% de los dientes evaluados fueron considerados sanos; el 44,81% se clasificaron como tratamiento endodóntico adecuado. La calidad del tratamiento endodóntico influyó significativamente en la condición del periodonto apical. Conclusiones: Los tratamientos evaluados presentaron alta frecuencia de periodontitis apical, la cual se asoció en buena parte a la alta frecuencia de tratamientos endodónticos inadecuados.
Outcomes and bioethical implications of lymphadenectomy in mastectomized patients: Importance and indication of ultrasound-guided fine-needle aspiration biopsy
Authors: Huertas-Moreno Marta , Gonzalvo-Cirac Margarita
Published: February 2023

Lymph node involvement is the main prognostic factor in breast cancer. Mastectomized patients usually undergo lymphadenectomy (LA) of micrometastatic sentinel lymph nodes (SLNs) despite the evidence of AMAROS trial to replace this therapy with radiotherapy in select cases. We demonstrate the ability of ultrasonography to detect non-metastatic or micrometastatic SLNs. Method: 132 patients who underwent mastectomy were evaluated. Ultrasound-guided fine-needle aspiration biopsy (FNAB) was indicated for suspicious lymph nodes. LA and SNL biopsy (SLNB) were performed in patients with positive and negative FNAB, respectively. LA was performed in cases of positive FNAB or positive SLNB except in the presence of isolated tumor cells and micrometastatic SLNs. The tumor burden after LA in patients with negative FNAB and positive SLNB was measured, and the presence of two or fewer positive SLNs was considered a low burden. Results: Sensitivity of FNAB for detecting positive lymph nodes in patients with a high tumor burden was 93% in our series, specificity was 84%. Positive (PPV) and negative predictive value (NPV) were respectively 60% and 79%. Conclusions: LA could have been avoided in 90% of mastectomized patients with negative FNAB and a low tumor burden who met the AMAROS criteria with a high NPV (79%).
EFEITO DA REMUNERAÇÃO COMO INCENTIVO GERENCIAL AO RISCO E AGRESSIVIDADE TRIBUTÁRIA NO BRASIL
Authors: Mamede Junior Eony , Vianna Brugni Talles , Soares Monte-Mor Danilo , Xavier Beiruth Aziz
Published: February 2023

Objetivo: O objetivo desta pesquisa foi investigar o efeito da remuneração como incentivo gerencial ao risco, medido por intermédio da estrutura de remunerações dos executivos, sobre a agressividade tributária no Brasil, no período de 2010 a 2021.
Método / abordagem: Foi proposto um modelo em regressão linear com dados em painel e efeito fixo de tempo e setor. Dentre as diversas medidas utilizadas na literatura internacional e nacional, utilizou-se nesta pesquisa quatro delas: a ETR, Cash ETR, ETR corrente e BTD. Contudo, no Brasil, dada a abrangência e importância dos tributos indiretos na carga tributária, é possível que a medida taxa de tributação representada na DVA possa representar melhor a agressividade tributária no Brasil. Analisou-se também se o cenário econômico pós-impeachment representou incentivos para as empresas em termos de agressividade tributária. 
Principais resultados: Destaque para a captura da agressividade tributária pelas métricas taxas de tributações sobre o valor adicionado.
Contribuições metodológicas / sociais / gerenciais: O fato de o país ora estar diante de um governo com viés mais liberal (e ora diante de um viés contrário), pode representar fundamentos para os achados, isto é, maior (menor) agressividade tributária. Assim sendo, uma contribuição social é que o efeito do incentivo gerencial ao risco relacionada com agressividade tributária pode reduzir a capacidade do governo em investir em bens públicos, conforme menciona a Teoria das Finanças Públicas. A contribuição gerencial deriva do fato de que maior incentivo a remuneração conduz a maior agressividade tributária, e, que talvez seja necessário maiores mecanismos de controles internos.
Originalidade / relevância: O estudo se justifica na medida que, em uma visão neoliberal, pode evidenciar que essa forma de governo pode induzir as empresas a maior agressividade tributária, principalmente quando a empresa remunera melhor seus gestores para correr mais riscos.  A originalidade surge do fato de usar a tributação da DVA para análise do incentivo a remuneração.
States and Experts: Assembling Expertise for Climate Change and Pandemics
Authors:   , Frandsen Søren Lund
Published: February 2023

This dissertation addresses the issue of expertise in climate change and pandemic preparedness. Economies and societies around the world are increasingly facing the consequences of a changing climate and more frequent infectious disease outbreaks. These problems are generally articulated as issues that require for their handling new forms of expertise and expert institutions that enable states to intervene in new ways. However, most existing research on climate and pandemic preparedness expertise tends to either focus solely on the transnational sphere or see the state and expertise as distinct. As a result, the role of the state in shaping climate and pandemic preparedness expertise remains underexplored.
Faktor-Faktor Yang Mempengaruhi Minat Menggunakan E- Money Flazz BCA di Kabupaten Tangerang
Authors: Zarasky Dwiki , Handrijaningsih Lies , Anisah Anisah , Ramadhani Septi Mariani Tis A.
Published: February 2023

ABSTRACTTechnological support for innovation brings changes in people's needs for a payment instrument that can meet speed, accuracy, and security in every electronic transaction. The electronic payment system or payment with electronic money (e-money) is influenced by advances in technological developments and changes in people's lifestyles. This study aims to determine the trust, social influence, and perceived benefits of the interest in using BCA E-Money Flazz in Tangerang City. Methods of data collection using questionnaires. The data of this research are primary, the determination of the sample uses a purposive sampling technique, and the respondents are consumers of e-money Flazz BCA in Tangerang City. The analytical tools in this study consist of; validity test, reliability test, classical assumption tests, multiple linear regression, t test, F test, and determination test. Processing the results of the questionnaire in this study using SPSS (Statistical Product and Service Solutions). The results showed that trust, social influence, and perceived benefits influenced the interest in using partially and simultaneously on the interest in using e-money.Keywords: Trust, Social Influence, Perception of Benefits, Interest in Using.
Neural Classification of Rotor Faults in Three-Phase Induction Motors using Electric Current Signals in the Frequency Domain
Authors: Palácios Rodrigo Henrique Cunha , Nunes da Silva Ivan , Fontes Godoy Wagner
Published: February 2023

Three-phase induction motors are widely used in different applications in the industry due to their robustness, low cost, and reliability. Untimely identification and correct diagnosis of incipient faults reduce cost and improve the maintenance management of these machines. This paper explores a new method for robust classification of rotor failures in three-phase induction motors (MITs) connected directly to the electrical network, operating in a steady-state, under unbalanced voltages and load conditions. Through an innovative methodology, an analysis of the electrical current signals from 1 hp and 2 hp motors in the frequency domain was performed. Such analysis was applied in constructing input matrices for a Multilayer Perceptron Neural Network (MLPNN) to detect faults. Furthermore, this methodology proved to be robust because the samples of the failing and healthy motors include voltage unbalance conditions in the electrical supply and a significant variation in the load applied to the motor shaft. Such load variation was used for the detection of failures of 1, 2, and 4 broken bars consecutively on the rotor and in the condition of 2 broken bars and 2 other broken bars diametrically opposite. The results were promising and were obtained using 847 real samples from an experimental bench used to construct the neural model and its respective validation.
Pediatric Oncology Chemotherapy Calendar Creation: A Nationwide Survey
Authors: Mueller Emily , Cochrane Anneli , Carroll Aaron
Published: February 2023

Background: An effective chemotherapy calendar system between
the clinician and the patient/caregiver can improve patient centered
outcomes. There is lack of research on how chemotherapy calendars are
created and what aspects are important to pediatric oncology providers.
Procedure: In an online survey of pediatric oncology providers,
we evaluated institutional practices, perceptions of chemotherapy
calendar creation, and desires for future tools. 220 survey participants
provided data, with a 10.4% response rate. Results:
Participants indicated that 72% always or most of the time their
institution provides a chemotherapy calendar, most commonly at the start
of a new cycle (90%) or with a dosing change (68%). Factors such as
the health literacy of the family, prior non-adherence, type of cancer,
and desire of the family affected the creation decision. Advanced
practice providers (45%) or nurse coordinator/navigators (43%) were
most likely to create the calendar. No significant difference was found
between the likelihood of creating a calendar and institutional size
(p=0.09) or provider years in practice (p=0.26). About 95% of
participants indicated chemotherapy calendar creation software that
improved ease and efficiency would be moderately to extremely useful.
Conclusion: Future efforts should focus on patient and
caregiver perspectives of chemotherapy calendar elements and
utilization.
Application of optical hydrogels in environmental sensing
Authors: Yang Shuo , Sarkar Shruti , Xie Xing , Li Dan , Chen Jianmin
Published: February 2023

The ever-increasing complexity of environmental pollutants urgently
warrants the development of new detection technologies. In this context,
sensors based on the optical properties of hydrogels enabling fast and
easy in situ detection are attracting increasing attention. Herein, the
target recognition and sensing mechanisms of two main types of optical
hydrogels (OHs) are reviewed and discussed: photonic crystal hydrogels
(PCHs) and fluorescent hydrogels (FHs). For PCHs, the environmental
stimulus response, target receptors, inverse opal structures, and
molecular imprinting techniques related to PCHs are reviewed and
summarized. Furthermore, the different types of fluorophores (i.e.,
compound probes, biomacromolecules, quantum dots, and luminescent
microbes) of FHs are summarized. Finally, the data from 138 papers about
different OHs are extracted for secondary statistical analysis. The
detection performance and potential of various OH types in different
environmental pollutant detection scenarios are evaluated, and compared
them to those obtained using the standard detection method. Based on
this analysis, some possible development directions are proposed,
including the fusion of various OHs, introduction of more hydrogel
technologies from the biomedical field to the environmental pollutant
detection field, and development of multifunctional sensor arrays.
Construction of Dynamic Alloy Interface for Uniform Li Deposition in Li-Metal Batteries
Authors: He Guang , Li Qingwen , Zhang Ziheng , Yang Zelong , Liu Yulu , Chen Jinjie
Published: February 2023

It is well accepted that a lithiophilic interface can effectively
regulate Li deposition behaviors, but the influence of the lithiophilic
interface is gradually diminished upon continuous Li deposition that
completely isolates Li from the lithiophilic metals. Herein, we perform
in-depth studies on the creation of dynamic alloy interface upon Li
deposition, arising from the exceptionally high diffusion coefficient of
Hg in the amalgam solid solution. As a comparison, other metals such as
Au, Ag and Zn have typical diffusion coefficients of 10-20 orders of
magnitude lower than for Hg in the similar solid solution phases. This
difference induced compact Li deposition pattern with an amalgam
substrate even with a high areal capacity of 55 mAh cm-2. This finding
provides new insight into the rational design of Li anode substrate for
the stable cycling of Li metal batteries.