bluuebunny/crossref_metadata_2025 huggingface dataset:
Undergraduates PhenotypingArabidopsisKnockouts in a Course-Based Undergraduate Research Experience: Exploring Plant Fitness and Vigor Using Quantitative Phenotyping Methods
Authors: Murren Courtney J. , Wolyniak Michael J. , Rutter Matthew T. , Bisner April M. , Callahan Hilary S. , Strand Allan E. , Corwin Lisa A.
Published: July 2019

We present a curriculum description, an initial student outcome investigation, and sample scientific results for a representative Course-Based Undergraduate Research Experience (CURE) that is part of the “Undergraduates PhenotypingArabidopsisKnockouts” (unPAK) network. CUREs in the unPAK network characterize quantitative phenotypes of the model plantArabidopsisfrom across environments to uncover connections between genotype and phenotype. Students in unPAK CUREs grow plants in a replicated block design and make quantitative measurements throughout the semester. This CURE enables students to answer plant science questions that draw from fields such as environmental science, genetics, ecology, and evolution. Findings indicate that this experience provides students with opportunities to make relevant scientific discoveries. Eighty percent of student datasets produced from the CURE met criteria for inclusion in the project database, indicative of student learning in data collection and analysis of quantitative plant traits. Student datasets uncovered novel effects of mutation on plant form. In addition, students’ science self-efficacy increased as a result of course participation, and faculty feedback on course implementation was positive. We present unPAK as a new network that supports CUREs and research experiences focused on collecting biological data made publicly available to the scientific community. The unPAK CUREs can be tailored to address instructor interests or pedagogical needs while involving students in research investigating quantitative plant phenotypes.
High-Throughput Sequence Analysis of Peripheral T-Cell Lymphomas Indicates Subtype-Specific Viral Gene Expression Patterns and Immune Cell Microenvironments
Authors: Nakhoul Hani , Lin Zhen , Wang Xia , Roberts Claire , Dong Yan , Flemington Erik
Published: July 2019

In this study, we utilized next-generation sequencing data from 7 different studies of peripheral T-cell lymphoma (PTCL) patient samples to globally assess viral associations, provide insights into the contributions of EBV gene expression to the tumor phenotype, and assess the unique roles of EBV in modulating the immune cell tumor microenvironment. These studies revealed potential roles for EBV replication genes in some PTCL subtypes, the possible role of additional human tumor viruses in rare cases of PTCLs, and a role for EBV in providing a unique immune microenvironmental niche in one subtype of PTCLs. Together, these studies provide new insights into the understudied role of tumor viruses in PTCLs.
Malignant intestinal obstruction during twin pregnancy: surgical resection of a myxoid liposarcoma without induction of labour
Authors: Paasch Christoph , Isbruch Annette , Strik Martin W , Siegel Robert
Published: July 2019

Myxoid liposarcoma (MLS) represents one of the three main morphological subgroups of liposarcomas. Extrapulmonary recurrence to the retroperitoneum and abdomen is common in MLS. A pregnant patient was referred to our hospital due to abdominal pain and obstipation. In the past, she had received a multimodal treatment of an MLS of the left dorsal thigh. Now, MRI revealed a 14.6×10.1×12.4 cm-sized tumour adjacent to the uterus with a known twin pregnancy (26th week). We performed surgery under tocolytic therapy. The tumour has been completely removed. The histopathological examination revealed a nodular manifestation of a moderately differentiated MLS arising from the mesentery. Eleven weeks later, our patient delivered healthy twins. This is the first report of surgical resection of MLS during a twin pregnancy. With a multidisciplinary approach and a concerted treatment by surgeons and obstetricians, surgical resection resolved malignant intestinal obstruction and enabled an uncomplicated continuation of pregnancy.
Cohort Profile: National health insurance service-senior (NHIS-senior) cohort in Korea
Authors: Kim Yong Ik , Kim Yeon-Yong , Yoon Jong Lull , Won Chang Won , Ha Seongjun , Cho Kyu-Dong , Park Bo Ram , Bae Sejin , Lee Eun-Joo , Park Seong Yong , Park Jong Heon , Lee Kyeong-ran , Lee Donghun , Jeong Seung-lyeal , Kang Hyung-soo
Published: July 2019

Purpose

The National Health Insurance Service (NHIS)-Senior was set up to provide high-quality longitudinal data that can be used to explore various aspects of changes in the socio-economical and health status of older adults, to predict risk factors and to investigate their health outcomes.

Participants

The NHIS-Senior cohort, a Korean nationwide retrospective administrative data cohort, is composed of older adults aged 60 years and over in 2002. It consists of 558 147 people selected by 10% simple random sampling method from a total of 5.5 million subjects aged 60+ in the National Health Information Database. The cohort was followed up through 2015 for all subjects, except for those who were deceased.

Findings to date

The healthcare utilisation and admission rates were the highest for acute upper respiratory infections and influenza (75.2%). The age-standardised (defined with reference to the world standard population) mortality rate for 10 years (through 2012) was 4333 per 100 000 person-years. Malignant neoplasms were the most common cause of death in both sexes (1032.1 per 100 000 person-years for men, 376.7 per 100 000 person-years for women). A total of 34 483 individuals applied for long-term care service in 2008, of whom 17.9% were assessed as grade 1, meaning that they were completely dependent on the help of another person to live daily life.

Future plans

The data are provided for the purposes of policy and academic research under the Act on Promotion of the Provision and Use of Public Data in Korea. The NHIS-Senior cohort data are only available for Korean researchers at the moment, but it is possible for researchers outside the country to gain access to the data by conducting a joint study with a Korean researcher. The cohort will be maintained and continuously updated by the NHIS.
Violent crime and socioeconomic deprivation in shaping asthma-related pollution susceptibility: a case-crossover design
Authors: Sheffield Perry E , Shmool Jessie L C , Kinnee Ellen J , Clougherty Jane E
Published: July 2019

Background

The objective of this study was to quantify and compare the relative influence of community violent crime and socioeconomic deprivation in modifying associations between ozone and emergency department (ED) visits for asthma among children.

Methods

We used a spatiotemporal case-crossover analysis for all New York City EDs for the months May–September from 2005 to 2011 from a statewide administrative ED dataset. The data included 11 719 asthmatic children aged 5–18 years, and the main outcome measure was percentage of excess risk of asthma ED visit based on Cox regression analysis.

Results

Stronger ozone–asthma associations were observed for both elevated crime and deprivation (eg, on lag day 2, we found 20.0% (95% CI 10.2% to 30.6 %) and 21.0% (10.5% to 32.5%) increased risk per 10 ppb ozone, for communities in the highest vs lowest quartiles of violent crime and deprivation, respectively). However, in varied models accounting for both modifiers, only violence retained significance.

Conclusions

The results suggest stronger spatiotemporal ozone–asthma associations in communities of higher violent crime or deprivation. Notably, violence was the more consistent and significant modifier, potentially mediating a substantial portion of socioeconomic position–related susceptibility.
Damping characteristics of full-scale grouped helical piles in dense sands subjected to small and large shaking events
Authors: Shahbazi Maryam , Cerato Amy B. , Allred Shawn , El Naggar M. Hesham , Elgamal Ahmed
Published: July 2019

A full-scale pile testing program was implemented using the large outdoor shake table at the University of California – San Diego. Nine steel helical piles with varying geometry were embedded in dense sand and tested individually and in 2×2 groups, comparing fixed and pinned pile head connections. The test piles were subjected to shake motions ranging from pulses and white noise to replicated earthquakes. Strain gauges attached to the exterior pile walls and accelerometers placed on the pile caps and within the soil provided data for analyzing the behavior of these piles. Foundation damping (herein soil–pile system) is a substantial parameter in seismic design of the foundation–structure. Therefore, the damping characteristics of the soil bed along with the combined soil–pile system consisting of single and grouped helical piles are discussed based on the experimental pulse, white noise, and shake excitations. Several methods, including logarithmic decrement, half-power bandwidth, and energy (equivalent) methods, were implemented to estimate the damping ratio over a range of strains. Based on the experimental data gathered from this study, the suitability and accuracy of different computational methods to determine damping ratio as well as the effect of type and location of instrumentation on the calculated damping ratio were evaluated.
Scale factor — Cosmic time relation and occurrences of future cosmic singularities with different redshift parametrizations of dark energy EoS-s
Authors: Bhowmik Swetalina , Biswas Ritabrata
Published: July 2019

While modeling our late time cosmically accelerated universe, it is popular to involve different dark energy (DE) models, the equation of state (EoS) of which can be taken as a function of the redshift and some unknown parameters. Barboza and Alcaniz have proposed one such kind of DE EoS model. We use some new parametrizations like Feng, Shen, Li, Li I and II and Polynomial parametrizations to get more accurate concepts about the fate of our expanding universe. We try to find how the hypothesis of the fate of our universe behaves in the above background of DE models. Possibilities of occurrences of future cosmic singularities are studied.
Reduction of Power Electronic Devices in a Single-Phase Generalized Multilevel Inverter
Authors: Mahato Bidyut , Majumdar Saikat , Jana Kartick Chandra
Published: July 2019

Multilevel inverters (MLIs) emerged as a boon to the industries due to the fact that it fulfils different industrial aspects such as reduced electromagnetic interference, lower maintenance, less installation area and reduced harmonic content. MLI generates a staircase output voltage with suitable combination of power devices and DC voltage sources. In this work, a generalized cascaded MLI is proposed that employs only a half-bridge converter rather than the full H-bridge converter for the polarity-reversal (on which the maximum DC link voltage appears) and thereby also reduces the required number of power switches. Five different types of algorithm in the proposed configuration have been studied and the most optimal algorithm is further elaborated and implemented. A specimen 7-level inverter of the proposed configuration is modeled in MATLAB/Simulink and is further implemented in the laboratory using the controller DS1103. The experimental results for different modulation indices are further amalgamated and verified with the simulation results. Nevertheless, a comparative assessment of different performance-related parameters of the proposed topology along with the generalized expressions is carried out and are also compared with some of the recently published MLI topologies.
Possible maximum mass of dark matter existing in compact stars based on the self-interacting fermionic model
Authors: Wang Xu Dong , Qi Bin , Yang Gao Le , Zhang Nai Bo , Wang Shou Yu
Published: July 2019

The dark matter admixed neutron stars (DANSs) are studied using the two-fluid TOV equations separately, in which the normal matter (NM) and dark matter (DM) are simulated by the relativistic mean field theory and self-interacting fermionic model, respectively. A universal relationship [Formula: see text] is suggested, where [Formula: see text] is the maximum mass of DM existing in DANSs, [Formula: see text] is the particle mass of DM ranging from 5[Formula: see text]GeV to 1[Formula: see text]TeV, [Formula: see text] is the interaction mass scale with the value 300[Formula: see text]GeV (0.1[Formula: see text]GeV) for weak (strong) interaction DM model. This simple formula connects directly the microcosmic nature of DM particle with its macrocosmic mass existing in DANSs. Meanwhile, such a formula exhibits that the existence of NM has little effect on [Formula: see text]. It is found that the ratio of radius of DM in DANSs over [Formula: see text] is a constant with the value about 12[Formula: see text] (7[Formula: see text]) for weak (strong) interaction DM cases. According to the calculated results, only for the strong interaction DM cases with [Formula: see text] to [Formula: see text][Formula: see text]GeV and central energy density [Formula: see text][Formula: see text]MeV/fm3, DM has obvious effect on the mass of compact star. Compared with the energy density of DM in the Milky Way galaxy, [Formula: see text][Formula: see text]MeV/fm3, the existence of DM might hardly affect the mass of compact stars in the Milky Way galaxy.
Particle Swarm Optimization Using Neighborhood‐Based Mutation Operator and Intermediate Disturbance Strategy for Outbound Container Storage Location Assignment Problem
Authors: He Yuyan , Wang Aihu , Su Hailiang , Wang Mengyao
Published: July 2019

Outbound container storage location assignment problem (OCSLAP) could be defined as how a series of outbound containers should be stacked in the yard according to certain assignment rules so that the outbound process could be facilitated. Considering the NP‐hard nature of OCSLAP, a novel particle swarm optimization (PSO) method is proposed. The contributions of this paper could be outlined as follows: First, a neighborhood‐based mutation operator is introduced to enrich the diversity of the population to strengthen the exploitation ability of the proposed algorithm. Second, a mechanism to transform the infeasible solutions into feasible ones through the lowest stack principle is proposed. Then, in the case of trapping into the local solution in the search process, an intermediate disturbance strategy is implemented to quickly jump out of the local solution, thereby enhancing the global search capability. Finally, numerical experiments have been done and the results indicate that the proposed algorithm achieves a better performance in solving OCSLAP.
Safety and Risk of Major Complications With Diagnostic Cardiac Catheterization
Authors: Al-Hijji Mohammed A. , Lennon Ryan J. , Gulati Rajiv , El Sabbagh Abdallah , Park Jae Yoon , Crusan Daniel , Kanwar Amrit , Behfar Atta , Lerman Amir , Holmes David R. , Bell Malcolm , Singh Mandeep
Published: July 2019

Background:

We aim to study the incidence of major complications related to procedure defined as in-hospital death, myocardial infarction, stroke, pericardial effusion or tamponade, percutaneous coronary intervention due to iatrogenic coronary dissection, or unplanned bypass surgery within 72 hours after diagnostic left heart catheterization (LHC; primary end point). Furthermore, all causes of in-hospital death after LHC were adjudicated and reported (secondary end point).

Methods and Results:

Diagnostic LHC procedures (aortic angiography; coronary, including graft, angiography; and left ventricular angiography) from January 1, 2002, through December 31, 2013, were identified using the clinical scheduling system at Mayo Clinic, Rochester, and complications were identified through electronic records.
International Classification of Diseases, Ninth Revision
billing codes were used. Registration was queried to identify all-cause mortality. All events were reviewed and adjudicated. There were 43 786 diagnostic LHC procedures; 97.3% were coronary angiograms. The mean age of patients was 64.5 years (13.6), and the majority were male (61.5%). Primary end point was seen in 36 (0.082%) procedures or 8.2 of 10 000 LHCs. Combined right sided procedures with LHC did not increase the risk of major complications. Cardiogenic and septic shock, cardiac arrhythmia, and postsurgical complication were the most common causes of in-hospital death after LHC.

Conclusions:

The overall rates of major complications related to diagnostic cardiac catheterization procedures are extremely rare. The majority of the deaths occurring post-diagnostic LHC procedures were secondary to acute illness rather than directly related to diagnostic procedure.
Long-Term Risk of Stroke After Transient Global Amnesia in Two Prospective Cohorts
Authors: Romoli Michele , Tuna Maria Assuncao , McGurgan Iain , Li Linxin , Giannandrea David , Eusebi Paolo , Tordo Caprioli Federica , Lotti Antonio , Salvadori Nicola , Sarchielli Paola , Gili Alessio , Mosconi Maria Giulia , Pellizzaro Venti Michele , Stracci Fabrizio , Ricci Stefano , Paciaroni Maurizio , Parnetti Lucilla , Calabresi Paolo , Rothwell Peter Malcolm
Published: July 2019

Background and Purpose—

Transient global amnesia (TGA) is known as a benign syndrome, but recent data from neuroradiological studies support an ischemic cause in some cases, which might suggest an increased susceptibility to cerebrovascular events. We determined the long-term risk of stroke after a first TGA in 2 independent prospective cohorts.

Methods—

In 2 independent prospective cohorts of patients with TGA (OXVASC [Oxford Vascular Study], population-based; NU (Northern Umbria) cohort, TGA registry), cardiovascular risk factors and long-term outcomes, including stroke and major cardiovascular events, were identified on follow-up. Cardiovascular risk factors were treated according to primary prevention guidelines. In OXVASC, the age-/sex-adjusted risk of stroke during follow-up was compared with that expected from the rate in the underlying study population.

Results—

Among 525 patients with TGA (425 NU and 100 OXVASC), mean (SD) age was 65.1 (9.5) years and 42.5% male. Hypertension (58.1%), dyslipidemia (40.4%), and smoking (36.4%) were the most frequent cardiovascular risk factors. The risk of stroke was similar in the 2 cohorts, with a pooled annual risk of 0.6% (95% CI, 0.4–0.9) and a 5-year cumulative risk of 2.7% (1.1–4.3). Moreover, the stroke risk in OXVASC cases was no greater than that expected in the underlying study population (adjusted relative risk=0.73; 0.12–4.54;
P
=0.74).

Conclusions—

TGA does not carry an increased risk of stroke, at least when cardiovascular risk factors are treated according to primary prevention guidelines.
Endocrine and Metabolic Disorders in Survivors of Childhood Cancers and Health-Related Quality of Life and Physical Activity
Authors: Pradhan Kamnesh R , Chen Yan , Moustoufi-Moab Sogol , Krull Kevin , Oeffinger Kevin C , Sklar Charles , Armstrong Gregory T , Ness Kirsten K , Robison Leslie , Yasui Yutaka , Nathan Paul C
Published: July 2019

Context

Childhood cancer survivors experience chronic health conditions that impact health-related quality of life (HRQOL) and participation in optimal physical activity.

Objective

The study aimed to determine independent effects of endocrine and metabolic disorders on HRQOL and physical activity.

Design, Setting, and Patients

Retrospective cohort with longitudinal follow-up of survivors of childhood cancer enrolled in the North American Childhood Cancer Survivor Study.

Main Outcome Measures

Medical Outcomes Short Form-36 estimated HRQOL, and participation in physical activity was dichotomized as meeting or not meeting recommendations from the Centers for Disease Control and Prevention. Log binomial regression evaluated the association of each endocrine/metabolic disorder with HRQOL scales and physical activity.

Results

Of 7287 survivors, with a median age of 32 years (range, 18 to 54 years) at their last follow-up survey, 4884 (67%) reported one or more endocrine/metabolic disorders. Survivors with either disorder were significantly more likely to be male, older, have received radiation treatment, and have experienced other chronic health conditions. After controlling for covariates, survivors with any endocrine/metabolic disorder were more likely to report poor physical function risk ratio (RR, 1.25; 95% CI, 1.05 to 1.48), increased bodily pain (RR, 1.27; 95% CI, 1.12 to 1.44), poor general health (RR, 1.49; 95% CI, 1.32 to 1.68), and lower vitality (RR, 1.21; 95% CI, 1.09 to 1.34) compared with survivors without. The likelihood of meeting recommended physical activity was lower among survivors with growth disorders (RR, 0.90; 95% CI, 0.83 to 0.97), osteoporosis (RR, 0.87; 95% CI, 0.76 to 0.99), and overweight/obesity (RR, 0.92; 95% CI, 0.88 to 0.96).

Conclusion

Endocrine and metabolic disorders are independently associated with poor HRQOL and suboptimal physical activity among childhood cancer survivors.
Emerging advances of in vivo detection of chronic traumatic encephalopathy and traumatic brain injury
Authors: Dallmeier Julian D. , Meysami Somayeh , Merrill David A. , Raji Cyrus A.
Published: July 2019

Chronic traumatic encephalopathy (CTE) is a neurodegenerative disorder that is of epidemic proportions in contact sports athletes and is linked to subconcussive and concussive repetitive head impacts (RHI). Although postmortem analysis is currently the only confirmatory method to diagnose CTE, there has been progress in early detection techniques of fluid biomarkers as well as in advanced neuroimaging techniques. Specifically, promising new methods of diffusion MRI and radionucleotide PET scans could aid in the early detection of CTE.

The authors examine early detection methods focusing on various neuroimaging techniques. Advances in structural and diffusion MRI have demonstrated the ability to measure volumetric and white matter abnormalities associated with CTE. Recent studies using radionucleotides such as flortaucipir and 18F-FDDNP have shown binding patterns that are consistent with the four stages of neurofibrillary tangle (NFT) distribution postmortem. Additional research undertakings focusing on fMRI, MR spectroscopy, susceptibility-weighted imaging, and singlephoton emission CT are also discussed as are advanced MRI methods such as diffusiontensor imaging and arterial spin labeled. Neuroimaging is fast becoming a key instrument in early detection and could prove essential for CTE quantification. This review explores a global approach to in vivo early detection.

Limited data of in vivo CTE biomarkers with postmortem confirmation are available. While some data exist, they are limited by selection bias. It is unlikely that a single test will be sufficient to properly diagnosis and distinguish CTE from other neurodegenerative diseases such as Alzheimer disease or Frontotemporal Dementia. However, with a combination of fluid biomarkers, neuroimaging, and genetic testing, early detection may become possible.
Imaging biomarkers in upper gastrointestinal cancers
Authors: Gabelloni Michela , Faggioni Lorenzo , Neri Emanuele
Published: July 2019

In parallel with the increasingly widespread availability of high performance imaging platforms and recent progresses in pathobiological characterisation and treatment of gastrointestinal malignancies, imaging biomarkers have become a major research topic due to their potential to provide additional quantitative information to conventional imaging modalities that can improve accuracy at staging and follow-up, predict outcome, and guide treatment planning in an individualised manner. The aim of this review is to briefly examine the status of current knowledge about imaging biomarkers in the field of upper gastrointestinal cancers, highlighting their potential applications and future perspectives in patient management from diagnosis onwards.
Spt5 modulates cotranscriptional spliceosome assembly in Saccharomyces cerevisiae
Authors: Maudlin Isabella E. , Beggs Jean D.
Published: July 2019

There is increasing evidence from yeast to humans that pre-mRNA splicing occurs mainly cotranscriptionally, such that splicing and transcription are functionally coupled. Currently, there is little insight into the contribution of the core transcription elongation machinery to cotranscriptional spliceosome assembly and pre-mRNA splicing. Spt5 is a member of the core transcription elongation machinery and an essential protein, whose absence in budding yeast causes defects in pre-mRNA splicing. To determine how Spt5 affects pre-mRNA splicing, we used the auxin-inducible degron system to conditionally deplete Spt5 in Saccharomyces cerevisiae and assayed effects on cotranscriptional spliceosome assembly and splicing. We show that Spt5 is needed for efficient splicing and for the accumulation of U5 snRNPs at intron-containing genes, and therefore for stable cotranscriptional assembly of spliceosomes. The defect in cotranscriptional spliceosome assembly can explain the relatively mild splicing defect as being a consequence of the failure of cotranscriptional splicing. Coimmunoprecipitation of Spt5 with core spliceosomal proteins and all spliceosomal snRNAs suggests a model whereby Spt5 promotes cotranscriptional pre-mRNA splicing by stabilizing the association of U5 snRNP with spliceosome complexes as they assemble on the nascent transcript. If this phenomenon is conserved in higher eukaryotes, it has the potential to be important for cotranscriptional regulation of alternative splicing.
Sequestration of microRNA-mediated target repression by the Ago2-associated RNA-binding protein FAM120A
Authors: Kelly Timothy J. , Suzuki Hiroshi I. , Zamudio Jesse R. , Suzuki Megumu , Sharp Phillip A.
Published: July 2019

Argonaute (Ago) proteins interact with various binding partners and play a pivotal role in microRNA (miRNA)-mediated silencing pathways. By utilizing immunoprecipitation followed by mass spectrometry to determine cytoplasmic Ago2 protein complexes in mouse embryonic stem cells (mESCs), we identified a putative RNA-binding protein FAM120A (also known as OSSA/C9ORF10) as an Ago2 interacting protein. Individual nucleotide resolution cross-linking and immunoprecipitation (iCLIP) analysis revealed that FAM120A binds to homopolymeric tracts in 3′-UTRs of about 2000 mRNAs, particularly poly(G) sequences. Comparison of FAM120A iCLIP and Ago2 iCLIP reveals that greater than one-third of mRNAs bound by Ago2 in mESCs are co-bound by FAM120A. Furthermore, such FAM120A-bound Ago2 target genes are not subject to Ago2-mediated target degradation. Reporter assays suggest that the 3′-UTRs of several FAM120A-bound miRNA target genes are less sensitive to Ago2-mediated target repression than those of FAM120A-unbound miRNA targets and FAM120A modulates them via its G-rich target sites. These findings suggest that Ago2 may exist in multiple protein complexes with varying degrees of functionality.
Demagnetization Method for Reducing Inrush Current of Single Phase 1 kVA Transformer
Authors: Negara I Made Yulistya , Darmawan Dicky Wahyu , Nurdianto Ryan , Riawan Dedet Candra , Musthofa Arif , Asfani Dimas Anton , Wahyudi Mochammad , Fahmi Daniar
Published: July 2019

This study deals with an effort to reduce inrush current of single phase transformer during its energizing. Inrush current affected by residual flux was minimized using demagnetization method in order to reduce residual flux trapped in the core of transformer. Two methods of demagnetization namely variable frequency-constant voltage (VFCV) and variablevoltage–constant frequency (VVCF) were applied and the effectiveness of both methods were then compared. Both methods were supplied with alternated direct current (DC), however the one was changed its frequency and the other one was changed its voltage. The results obtained after transformer was demagnetized using these methods show that VFCV method educed inrush current up to 76%, on the other hand VVCF ethod reduced inrush current only up to 37%. Moreover,demagnetization time process of VFCV method was about 1.46 s, which is 1 s faster than VVCF method.
miR-99b-3p is induced by vitamin D3 and contributes to its antiproliferative effects in gastric cancer cells by targeting HoxD3
Authors: Chang Su’e , Gao Zhengchao , Yang Yang , He Kang , Wang Xiaofei , Wang Lumin , Gao Ning , Li Haopeng , He Xijing , Huang Chen
Published: July 2019

Vitamin D3 is known to have anticancer actions by affecting tumorigenesis including the cell cycle and cell apoptosis in gastric cancer (GC) cells; the genes including microRNAs (miRNAs) regulated by vitamin D3 signaling remain discovered. miR-99b-3p, the tumor suppressor gene, is not only decreased in GC tissues, but is also induced by vitamin D3 through the vitamin D receptor (VDR) binding on the promoter domain of miR-99b. Further study indicates that miR-99b-3p inhibits cell viability and induces cell arrest in the S-phase in GC cells, the direct target gene of miR-99b-3p is verified to be HoxD3, which is also overexpressed in GC cell lines. Overall, our results show that miR-99b-3p mediates the antiproliferative of vitamin D3 in GC cells and might hold promise for prognosis and therapeutic strategies for GC treatment.
Essential oils as a source of bioactive molecules
Authors: León-Méndez Glicerio , Pájaro-Castro Nerlis , Pájaro-Castro Enilson , Torrenegra- Alarcón Miladys , Herrera-Barros Adriana
Published: July 2019

Nature gives us a large number of compounds with interesting biological properties, within them we have essential oils, which are an important source of new bioactive molecules, which can replace synthetic chemicals, since they are friendly to the environment and they are less toxic. Currently there are more than 20.000 publications in which essential oils are related to some biological activity, according to the search made in different databases until January 2018. This confirms the wide utility of essential oils as the main source of bioactive metabolites, which can be used in different areas of our life.
Numerical modelling of leachate transport into water bodies at a landfill site
Authors: Naveen B P , Sumalatha J , Malik R K
Published: July 2019

This study was carried out to assess the possibility of reclamation of a closed landfill site located at Mavallipura near Bangalore, India. The existing liner system at this site had not completely prevented leachate migration to the underlying aquifers, which required management and control to avoid adverse impact on the surrounding environment. Batch leaching tests and column tests were conducted to estimate the migration rates of different contaminants through soil. The transport rates thus obtained were used as input to the fluidyn-Pollusol model to assess the leachate migration from the landfill. This model may be useful in analysing leachate migration from the landfill and its associated environmental impacts, particularly on groundwater wells and surface water ponds downstream of the site. The results indicated that landfill leachate leakage had a significant effect on the quality of surrounding water bodies.
Developing Learning Multimedia to Improve Critical Thinking in Mathematics at Class V of Elementary School
Authors: Supatmo Supatmo , Ghufron Anik
Published: July 2019

This study aims (1) to produce a learning multimedia which is feasible to improve critical thinking in mathematics at class V of elementary school, (2) to ﬁnd out the effectiveness of learning multimedia to improve critical thinking in mathematics at class V of elementary school. This study is a research and development referring to the opinion of Borg & Gall. The subject trials are the ﬁfth-grade students of SD Muhammadiyah Special Program Boyolali. The results of this research is a software of learning multimedia. The results showed that the developed of learning multimedia is feasible and effective to improve critical thinking of students. Based on the test results show that the effectiveness of the learning multimedia is effective in increasing critical thinking of students. It is based on the results of the implementation of the test ﬁeld that indicates p<0.05, which means a signiﬁcant inﬂuence critical thinking on student learning using learning multimedia.
Character Education Through School Literacy Program in Elementary School
Authors: Wuryandani Wuri , Fathurrohman Fathurrohman , Suparlan Suparlan
Published: July 2019

This study aimed to explore the character education through the school literacy program in Elementary School. This research is motivated by the importance of character education, one of them was school literacy program in elementary school. This research was a descriptive research with qualitative approach. Research subjects were principals, teachers, school literacy teams, and students at Muhammadiyah Sapen Elementary School in Yogyakarta. Data collection techniques used in this study were observation, interview, and documentation. Technique of examination of data validity used triangulation. The analysis technique used inductive analysis technique, that is analysis which depart from data and boils down to general conclusions. The steps of data analysis include: data reduction, unitization and categorization, display data,andconclusions.TheresultsshowedthatliteracyactivitiesatSDMuhammadiyah Sapen Yogyakarta had been implemented long before the government launched the school literacy program. Literacy activities at the school are implemented by maximizing collaboration between teachers and school librarians. Along with the school literacy movement program from the government, the school ﬁx the literacy activities undertaken. School literacy movement activities conducted in 3 stages of habituation, development, and learning. In school literacy movement there are values of character that are grown the responsibility, discipline, appreciate achievement, conﬁdence, creative, reading, and communicative.
Factors Inﬂuencing Teacher Professionalism Development on Secondary School
Authors: Lutﬁyana Anisa , Sugito Sugito
Published: July 2019

Development is a permanent issue in school worldwide which teacher demand in enhance their competence, especially in professionalism competence. The main purpose of this article is to investigate whether three factors were inﬂuence teacher professionalism development, those are (1) leadership of principal, (2) organizational commitment, (3) school culture. This research is survey research. The population was 182 teachers of Muhammadiyah Secondary School of Yogyakarta. A sample of 162 teacherswasestablishedusingthesimplerandomsamplingtechnique.Thedatawere collected through questionnaire that had been tested for validity and reliability. The data analysis technique used double regression. The research ﬁnding shows that there was a positive and signiﬁcant effect of: (1) leadership of principal on teacher professionalism development, as much 15,7%, (2) organizational commitment on teacher professionalism development, as much 15,7%, (3) school culture on teacher professionalism development, as much 21,1%.
The Bidikmisi Scholarship: What Work and What Doesn’t Work?
Authors: Wibowo Udik Budi , Sudiyono Sudiyono , Lestari Slamet
Published: July 2019

This study aims to describe the implementation of an educational scholarship program for senior high school graduated student who come from economically poor families (Bidikmisi).ThisscholarshipspendingalargeamountofStatebudget,therefore,needs to be examined accountability of the used. Research using quantitative approach with survey method. The research found that the Bidikmisi scholarship support increased access to learning in the higher education, ensuring students retention and completion. In addition, it is also found a high learning motivation among students scholarshipawardeeofBidikmisi;butnearlyhalfofthemhavealowlearningmotivation. Subsequent management of scholarships has been running well, but not optimal. That is why, the management scholarships still need to be addressed, including ﬁnancial literacy coaching to student scholarship awardee of Bidikmisi.
Community-Based Empowerment in Kaki Langit Market Tourist Village Bantul Yogyakarta
Authors: Yunita Wiwin , Suryono Yoyon
Published: July 2019

This research study was conducted to observe activity designs of community-based empowerment in order to ﬁnd the result of the empowerment through tourist village development. The method employed in this study was descriptive qualitative. The instruments used to collect the data were observation, intervews, and documentation. The applied data analysis techniques were data collection, data reduction, data display, and conclusion drawing. The result of this study pointed that the applied designs of the community-based empowermentwere: association, mentoring, funding, constructionoffacilitiesandinfrastructure,cooperation,andformationoforganizations. The implemented model or design hit its target. The target was determined based on the community needs. The results of the implementation of the empowering program were independence and economic improvement of the community.
Addie Model: Development of Anti-Corruption Education Materials in Elementary School
Authors: Suyantiningsih Suyantiningsih , Rahmadonna Sisca
Published: July 2019

This study aims to develop anti-corruption education materials based on integrity
values for elementary school students in Yogyakarta. This research is a research
and development using ADDIE (Analyze, Design, develop, implement, evaluate)
development models. Data was obtained through literature studies, observation,
interviews, and Focus Group Discussion (FGD) which were then processed descriptively
qualitative. The results showed that the ADDIE model used to develop the material
illustrates that the integrity value that is most needed to be developed in anti-corruption
education for elementary school students is the value of honesty and simplicity, this is
obtained from the analysis in the development of ADDIE and reinforced by the answers
given by the teacher during FGD, where 31.50% of teachers chose honesty values and
23.3% of teachers chose the value of simplicity
Is Modelling Technique Effective to Improve Achievement Motivation of Junior High School Students?
Authors: Suny Ismail , Partini Suardiman Siti
Published: July 2019

This research has purpose to find out the effectiveness of modelling technique toward
achievement motivation of Muhammadiyah 2 Junior High School Students, Mlati. It
was a quasi-experimental research by using non-equivalent control group design.
Techniques of collecting data were achievement motivation scale to find out level
of achievement motivation actions. The subject were 20 low scored achievement
motivation students. The techniques of analyzing the data were nonparametric statistic
method using Wilcoxon test by using 5% significant level. The findings showed
improvement of achievement motivation of experiment group, 8.4%. Meanwhile, the
control group improved 0.13%.
Contents Analysis of the Pancasila Education and Citizenship Students’ Book for High School Curriculum 2013
Authors: Marsudi K.E.R , Sunarso Sunarso
Published: July 2019

Based on the results of preliminary observations of the Pancasila and Citizenship
Education (PPKn) textbooks for high schools both in class X, XI and XII Curriculum
2013 it was found that there were some writing errors in the material. This study aims
to determine the consistency of high school civics textbook material in accordance
with the prevailing curriculum, namely the curriculum 2013. The analyzed books are
civics textbooks for class X, XI and XII by the Ministry of Education and Culture of the
Republic Indonesia published in 2017 and 2018. This civics textbook is considered
not good enough and not yet suitable for use. In this textbook there has been
discussion of the material with training in competencies both cognitive, affective and
psychomotor. But in this book, in addition to some indicators that show relevance to
the applicable curriculum there are also several indicators that do not show relevance
to the applicable curriculum. It is said relevant because of the indicators analyzed, this
book has presented well with the discovery of the diversity of values and cutting-edge
material. Based on the consistency of this book said to be inconsistent, there are still
some overlapping material because it experiences repetition at the next class level.
This textbook is not yet suitable to be used in the teaching and learning process by
students to achieve the learning objectives, therefore it still needs revision for the next
school year.
The Implementation of Gerakan Literasi Sekolah (Gls) Program in Elementary School
Authors: Wahyuningsih Sri , Mustadi Ali
Published: July 2019

The purpose of Gerakan Literasi Sekolah (GLS) program is to manage schools as a
literary ecosystem. The components of GLS program such as facilities & infrastructure,
activities, and school literacy team determine the successful implementation of
the program. This study aims at describing the condition of the GLS program
implementation in state elementary schools of Sleman district. Data were obtained
through a questionnaire by elementary school teachers. This reserach gauges the
implementation level of GLS program from several aspects like the conditions of
facilities & infrastructure, the school literacy team, the public involvement, and the
activities of GLS program. The research resulted that 44% of the schools in Sleman
district have been implemented GLS program in good category.
Analysis Of Students’ Conceptual Understanding Assisted By Multirepresentation Teaching Materials in the Enrichment Program
Authors: Susilaningsih Endang , Fatimah Siti , Nuswowati Murbangun
Published: July 2019

Thispurposeofthisresearchwastodeterminethestudents’conceptualunderstanding assisted by acid-base multi-representation teaching materials in the enrichment program. The type of research was case study that used combination of qualitative and quantitative methods by involving 49 second grade science students of State High School in Kudus who have passed/completed acid-base material. The sampling technique was carried out by purposive sampling. Conceptual understanding was analyzed using reasoned questions, namely three tier multiple choice test as pretest andposttest.Theresultsshowedthatstudents’conceptualunderstandingofacid-base material was considered as high category. Achievement of students’ conceptual understandinghasincreased,asseenfromtheresultsofstudents’pretestandposttest namely from 37% to 71%. Overall, enrichment learning assisted by multi-representation teaching materials is effective when used in learning so that the achievement of students’ conceptual understanding of acid and base material is categorized as high category.
Natural Xilan Production From Corncobs (Zea Mays L.) With Extraction Method
Authors: Arifan Fahmi
Published: July 2019

Corn (Zea mays L.) not only used as food by humans, however also used for animal feed and industrial materials but in part of corncobs still untapped, corncobs is a lignocellulosic material with 38,99% ﬁber which contain the highest xilan (12,4%) comparedwithotheragriculturalwaste.Theobjectiveofthisresearchwastogetxylan fromcorncobswithextractionmethod.Xylanextractionfromcorncobsweredoneintwo steps, ﬁrstly deligniﬁcation process in NaOCl with concentration 0,5 on temperature 28∘C, solids which resulting from immersion in NaOH solution with concentration 5%, 10%, 15%, and 20% for 24 hours with temperature 20, 40, and 70∘C.the resulting of ﬁltrate were neutralized with HCL 6N, futhermore centrifuge during 30 minute with 4000 rpm. Water soluble xylan can separated with ethanol 95% with ratio supernatan and ethanol 1:3, yielding 12.9% of xylan. The solubility of xylan produced with alkali (NaOH 1%), HCl 1N, ethanol, in cold and hot water was observed. Quantitative and qualitative analysis of xylan were done using HPLC by measuring retention time. The instrumen used with HPLC Shimadzu C-R3A, C18 column type, water mobile phase, Refractive index detector with ﬂow rate 0,8 ml/minute result showed with purity 96%.
Framework Considerations for Rural Resilience Toward Land Degradation
Authors: Rahmawati Isna , Rudiarto Iwan
Published: July 2019

Landdegradationisaglobalproblemwhichinvolvesclimate,soil,vegetation,economic, andpopulationconditions.Landdegradationoccursinruralagriculturallandasaresult of agricultural activities. Land degradation can ultimately eliminate the sustainability of environmental, social and economic in rural areas. Land degradation problems decline environmental, social and economic conditions that decrease rural resilience. Basically the components of community resilience according to Kusumastuti [14] can be used to assesstheresilienceofruralcommunitiesbecausetheyinvolvenotonlyenvironmental, social and economic aspects but also community cappacity, institutions, infrastructure and hazards. Varoius studies were still involve environmental, social and economic
Education Mapping As a Reference Village Program in Cigadung, Brebes Regency Through Sistem Informasi Pembangunan Berbasis Masyarakat (SIPBM)
Authors: Latiana Lita , Hidayah Isti
Published: July 2019

The mandate of the Child Protection Act Article 9 states that every child has the right to receive education and teaching in the context of his personal development and the levelofhisintelligenceinaccordancewithhisinterestsandtalents.Childrenunderthe age of 18 in Cigadung Village are around 28% of the total population in the village. Therefore, the government or community has the responsibility to provide education services for school-age children. Based on this background, the problem in this study are1)Howistheconditionofaccesstoeducationservicesforchildrenaged6-18years in Cigadung Village?; and 2) How is the alternative program for school-age children in accordance with the results of the SIPBM application?. This research is a descriptive study by analyzing data quantitatively and qualitatively. In this case the research subjectwasthefamilyheadoftheCigadungVillage.Dataretrievalisdonebyinterview method and documentation. While the data that has been obtained will be narrated. The results of the study showed that a 564 out of a total of 1216 school-aged children were served access to education. Thus, there are around 53% of school-aged children in Cigadung Village who have not attended school. The top three factors that cause these children not to go to school are the perceived better work, economic burden and better assumption of marriage. Meanwhile, several alternative programs that are in accordancewith the SIPBM applicationnamely GerakanKembali Bersekolah,Forum Masyarakat Peduli Pendidikan Desa and “Kejar Paket”.