bluuebunny/crossref_metadata_2025 huggingface dataset:
Badanie opinii studentów na temat bezpieczeństwa zdrowotnego w stanie pandemii. Budowa i zasady stosowania autorskiego kwestionariusza ankiety
Authors: Wrzesińska-Sadłowska Joanna , Serwin Maria , Waśkowska Adrianna
Published: January 2023

Nowadays, the issue of health safety is gaining importance, and the last months of the pandemic confirm the legitimacy of the interest in this topic. In order to effectively minimize health risks, especially those related to neglect in the area of public health, decisive educational activities should be undertaken, prior to the diagnosis of the level of knowledge and beliefs in this area. The effectiveness of these activities will largely depend on the ability to properly identify educational needs, but also to know the barriers that may hinder this process. The aim of this study is to present the methodology of researching students’ opinions on health safety, with particular emphasis on the structure and principles of using the proprietary questionnaire. The designed research tool – a questionnaire for researching students ‘opinions on health safety in a pandemic state (BOS-Bezp’21) – is designed to identify students’ opinions on selected aspects of institutional activities as well as personal beliefs and activities undertaken in the context of the prevailing virus pandemic Sars-Cov-2. The conducted statistical analyzes allow for the recognition of BOS-Bezp’21 as a reliable diagnostic tool.
Wojewódzka Stacja Pogotowia Ratunkowego w Bydgoszczy w obliczu pandemii COVID-19
Authors: Paciorek Przemysław , Skrzyński Wojciech , Wiśniewski Krzysztof , Romaniuk Maciej
Published: January 2023

The year 2021 with the SARS-CoV-2 virus was a difficult period both for the society and for the entire health care system in Poland. The lack of experience in the context of working with a rapidly spreading infectious disease that caused periodic exacerbations of the failure of the State Medical Rescue System forced the search for solutions to improve the operation of medical rescue teams. In many situations, the encountered problems have been successfully resolved, in others, unfortunately, we still see a real threat. Many hours of absences of the Medical Rescue Teams related to the long time of implementing non-standard calls, the need for disinfection, unexpectedly excluded personnel from being ready to be on duty are just one of the many factors that paralyzed the State Medical Rescue System. The problem of the pandemic will remain in the health care system much longer than originally expected, therefore locally developed solutions must be constantly evolved to meet the challenges that will put the National Medical Emergency System to the test many times.
History Students’ Awareness of “The Importance of Knowing How History is Written
Authors: KAYA Ramazan , GÜNAL Hasan
Published: January 2023

The purpose of this study is to reveal history students’ regarding the importance of knowing how history is written. The study was carried out with a qualitative methodology in particular basic qualitative research design. The research was carried out with 80 senior students in the department of history and taking pedagogical formation training at two universities located in the east of Turkey in 2017-2018 academic year. The data were collected via both interview and open-ended questions. The results revealed that most of the students do not read any books about historical methodology outside the classroom and show interest in this field. Nearly all of the participants considered it necessary for the students studying in the history department to know how history is written, due to the many contributions they will provide, especially in to do the academic career. More than half of the participants stated that in order to learn history more accurately and to prevent believing in unfounded things, it is necessary for other segments of the society to know how history is written.
Sanatla İlişkilendirilmiş Matematik: İlkokul 4. Sınıf Öğrencilerinin Uygulamaları
Authors: YILMAZ Dilara
Published: January 2023

Bu araştırmada matematik ve sanatın bir araya getirildiği bütüncül bir öğretimin bir denencesi olarak 4. Sınıf öğrencilerinin örüntü, simetri, geometrik şekiller ve cisimler konuları ile bu konulara ait kavramları sanat eserleri aracılığıyla işlenmesi amaçlanmıştır. Araştırmada etkinlikler Escher ve Kandinsky’nin sanat eserleri aracılığıyla uygulanmış ve incelenmiştir. Araştırma öğretim deneyi modeline uygun olarak 15 dördüncü sınıf öğrencisi ile toplam beş haftada gerçekleştirilmiştir. Veri toplama aracı olarak, tasarlanan etkinliklere dayalı öğrenci yanıt formları, araştırmacı gözlem formu ve etkinliklere yönelik hazırlanan açık uçlu sorulardan oluşan anket formu kullanılmıştır. Araştırmada ele alınan her bir konuya ilişkin etkinlikler tasarlanarak öğretim deneylerine dayalı dersler yürütülmüştür. Buna ek olarak öğretim deneyinde ele alınan kavramları pekiştirmek için somut ve sanal materyallere dayalı dersler işlenmiştir. Öğrencilerin duyuşsal durumlarını ölçmek amacıyla ise anket formu kullanılmıştır. Araştırmada matematik ve sanat etkileşimi ile yürütülen dersler sonucunda öğrencilerin motivasyonlarının arttığı, matematik dersine ilişkin tutumlarında olumlu gelişme olduğu, örüntü ve simetri konularında anlam karmaşası yaşadıkları ve geometrik cisimler konusunda zorlandıkları belirlenmiştir. Bu sonuçlar ışığında ilkokul matematik derslerinde bu araştırmada ele alınandan farklı konu ve kavramlarıfarklı sınıf düzeylerindeki öğrenciler ile çalışılması önerilmektedir.
Development of Number Sense Test for Eighth-Grade Students: A Validity and Reliability Study
Authors: BİRGİN Osman , PEKER Elif Seval
Published: January 2023

The aim of this study was to develop a test for determining the number sense performance of eighth-grade students. This study was conducted with 405 eighth-grade students. The SPSS 17.0 and LISREL 8.8 software were used for data analysis. Data were analyzed by using the item analysis, exploratory and confirmatory factor analysis, and Cronbach’s alpha reliability tests. As a result of the analyzes, the number sense test was developed, which consists of 38 multiple-choice items and six number sense components and can explain 48.5% of the total variance. Cronbach's alpha reliability coefficients of the number sense test and its sub-components were found to be between 0.72 and 0.82, and the item-total correlations were between 0.30 and 0.47. The first and second-level confirmatory factor analysis results confirmed that the number sense test consisted of six components and that the established models fit well. As a result of this study, it was determined that the number sense test is a valid and reliable measurement tool in determining the number sense performance of eighth-grade students.
The Relationship between the Teacher Qualities Perceived by Students and the Achievements of High and Low Socioeconomic Level Students
Authors: İNCİ Sibel , KAYA Volkan Hasan
Published: January 2023

Teacher qualities play a key role in students’ achievement. In general, however, disadvantaged students may not have as much opportunity to benefit from teacher support as advantaged students. Therefore, this study aims to find out the relationship between the teacher qualities and the achievements of high and low socioeconomic level students in math and science literacy, and reading. Data were obtained from the Program for International Student Assessment (PISA) 2018 results. The study is a quantitative analysis using a relational model, with a sample consisting of 25% low socioeconomic level students and 25% high socioeconomic level students. The findings of this study indicate a more positive impact of adaptive instruction, teacher-directed instruction, and disciplinary climate on high socioeconomic students than on low socioeconomic students. However, the impact of teacher cognitive feedback on both student groups' achievement in all domains is negative.
Psikolojik Danışman Adaylarının Eğitim Kurumlarında Maruz Kaldığı Duygusal İstismar ve Yansımaları: Nitel Bir Çalışma
Authors: ŞAHİN YOLUK İrem , GÜÇRAY Sonay
Published: January 2023

Çocukluk çağında ebeveyn tarafından maruz kalınan duygusal istismar yetişkinlikteki yaşantıları ne kadar etkilerse öğretmen ve diğer okul personeli tarafından maruz kalınan duygusal istismarın da en az o kadar etkileyebileceği düşünülmektedir. Bu çalışmada psikolojik danışman adaylarınıngeçmişte eğitim kurumlarında maruz kaldıkları duygusal istismarın yetişkinlik yaşamlarına yansımaları nitel araştırma metodları aracılığıyla incelenmiştir. Araştırmaya Akdeniz bölgesinde bulunan bir üniversitede eğitim-öğretime devam etmekte olan 18 lisans son sınıf öğrencisi (11 kadın, 7 erkek) katılmıştır. Veri toplamak amacıyla araştırmacılar tarafından hazırlanan "yarı yapılandırılmış görüşme formu” ve katılımcıların demografik bilgilerine ulaşmak amacıyla "kişisel bilgi formu" kullanılmıştır. Toplanan veriler nitel veri analizi yöntemlerinden içerik analizi yoluyla analiz edilmiş ve bulgular temalar hâlinde sunulmuştur: (1) duygusal istismarın öznel yansımaları, (2) duygusal istismarın bireyin aile ve arkadaş ilişkilerine yansıması, (3) duygusal istismarın bireyin eğitim-öğretim yaşamına yansıması, (4) duygusal istismarın bireye katkıları ve bireyin yaşamında yarattığı engelleyici unsurlar, (5) duygusal istismara maruz kalınmasaydı oluşabilecek benlik tasarımları. Araştırma sonuçları eğitim kurumlarında öğretmen ve okul yöneticileri tarafından duygusal istismara maruz kalan bireylerin bu yaşantının yansımalarını uzun süre taşıdığına ve taşımaya devam ettiğine işaret etmektedir. Birey, ailesi ve yaşadığı çevre tarafından desteklense de maruz kaldığı duygusal istismarın duygu, düşünce ve davranışları üzerinde çoklu yansımalar yarattığı gözlemlenmiştir.
The Effect of University Students' Achievement Orientations on Lifelong Learning Tendencies: A Structural Equation Model Study
Authors: ARSLAN Aysel
Published: January 2023

In this study; İt is aimed to determine the effect level of achievement goal orientations on lifelong learning tendency. In the study, the general survey model and probability-based random sampling method, which are among the quantitative research methods, were preferred. The sample of the study consisted of a total of 1312 students, 726 female and 586 male, who continue their education in different faculties and vocational schools in the city center of Sivas Cumhuriyet University in the spring semester of the 2020-2021 academic year. The data of the study were obtained by applying the "2x2 Achievement Orientation Scale" developed by Arslan and Akın (2015), which was adapted to Turkish by Elliot and Murayama (2008), and the "Lifelong Learning Disposition Scale" developed by Diker-Coşkun (2009). Research data were analyzed using normality tests, independent groups t test, ANOVA, Tukey, SEM, and CFA statistical methods. In the findings obtained in the research; It is observed that the mean scores obtained by the students from both scales differ significantly according to the variables of gender, type of school, type of education, economic status, place of residence, the type of high school graduated from, and achievement orientation has an effect on lifelong learning.
The Prediction of Logical Thinking Levels of Prospective Teachers Through Some Variables
Authors: BAŞERER Dilek , BAŞERER BERBER Zeynep
Published: January 2023

Logical thinking is of importance for true thinking, making true decisions, being able to solve problems in a true way and being in true communication. A study was planned in order to see this importance with regard to determining what the factors affecting logical thinking levels. In the current study, some variables (gender, age, class level, academic success, socio-economic level, critical thinking and communication barrier) which are thought to have an impact upon logical thinking were studied and discussed depending on the related literature. For that reason, correlational survey model, one of the general survey models based on quantitative data, was used in the study. The working group was made up of the students of University. In the study which was carried out with a total 400 people, Personal Information Form, The Critical Thinking Tendency Scale, The Scale of Interpersonal Communication Barriers and Logical Thinking Scale were used as a data collection tool. Data analysis was conducted with multiple regression analysis in order to determine to what extent the scores that prospective teachers obtained from the Logical Thinking Scale were predicted by independent variables. It was found trough the data obtained in the study that logical thinking was predicted by the variables of gender (in favour of males), critical thinking (positively) and communication barriers (negatively).
Identifying two pathogenic variants in a patient with pigmented paravenous retinochoroidal atrophy
Authors: Liu Zeyuan , Wang He , He Xiaoli , Tao Dan , Li Li
Published: January 2023

Little is known about the genetic background of pigmented paravenous retinochoroidal atrophy (PPRCA) due to rarity of patients. In this study, we identified two pathogenic variants in RPGRIP1 in a 2-year-old boy with PPRCA screened by whole-exome sequencing (WES). The patient presented to our department with photophobia for 17 months, and then he underwent fundus photography and fluorescein fundus angiography. Genomic DNA was extracted from peripheral blood of the proband and the parents. Trio-WES strategy was utilized to identify the causal variants from the proband and the parents, followed by validation based on Sanger sequencing. The patient was finally diagnosed with PPRCA after differential diagnosis. Two heterozygous pathogenic variants were detected by WES according to the American college of medical genetics and genomics guidelines, including NM_020366.4: c.2592T > G: p.Y864* and NM_020366.4: c.154C > T: p.R52* in RPGRIP1 located in exon 17 and exon 3, leading to termination codon, respectively. This is the first study reporting pathogenic variants within RPGRIP1 as causal for PPRCA.
Pure Economic Losses from the Russian Perspective
Authors: Nektov Artyom , Stepanov Semyon
Published: January 2023

The article is devoted to the issue of compensation for pure economic losses under Russian law. The category of pure economic losses came into the focus of Russian researchers relatively recently. Currently, the mainstream discussion of Russian scholars on the topic is based on the analysis of foreign cases and arguments related to them. Meanwhile, Russian case law has been enriched with precedents that can lead to a non-consistent way for resolving such kind of disputes. We propose the approach that the reimbursement of pure economic losses directly depends on the determination of the limits of tort liability or its conditions. Thereby, the comprehensive analysis of these conditions will make it possible to more clearly define the scope of the pure economic losses. Nevertheless, the conservatism of the Russian doctrine of tort law and the inconsistency of law enforcement does not always allow us to apply the usual conditions of tort liability as a method for analyzing pure economic losses under Russian law. Thus, we consider the arguments for and against the recovery of pure economic losses that have developed abroad and are often discussed by Russian scholars. Besides, the article deals with the most important cases in which the courts have granted claims for the recovery of the pure economic losses. Nevertheless, the reasoning of the courts does not always look satisfactory, since it has not always been supported by the strict analysis of conditions of tort liability. We also consider cases where courts’ attention to factual circumstances prevails over their legal analysis. Although these cases reflect the current Russian political agenda, we posit that they provide with valuable material for legal discussion on the issue of recovery of pure economic losses. The coherent application of liability conditions would have removed the political context of these cases and led to the concentration of courts’ attention on the legal details of the cases. As a result, the authors postulate the need to analyze the core of tort liability, i.e., its conditions. This will create a more subtle mechanism for setting up tort liability and develop immunity of tort law to exogenous factors related to the political context.
Staatsbürger:innenschaft unter Bedingungen des Krieges – Expansives Lernen als Möglichkeit für Vergebung und Versöhnung
Authors: Engelmann Sebastian
Published: January 2023

Krieg verändert pädagogische Verhältnisse – die Reflexion dieser Veränderungen bleibt aber oft aus. Statt über die Bedingungen pädagogischen Handelns in Kriegszeiten wird zumeist nur der Weg zum Frieden diskutiert. Unter Rückgriff auf das Konzept der belligerent citizenship wird in diesem Beitrag herausgearbeitet, wie sich die Voraussetzungen pädagogischen Handelns in Kriegszeiten verändern. Zudem wird das Konzept der expansive education eingeführt, um auszuweisen, wie demokratie- und menschenrechtspädagogische Arbeit ermöglicht werden kann. Anerkennung von Schuld, Vergebung und Versöhnung sind zentrale Begriffe, die weiter zu reflektieren sind. Der Artikel leistet so einen grundlagentheoretischen Beitrag für pädagogisches Denken und Handeln unter kriegerischen Bedingungen.
Trotz Krieg vom gerechten Frieden sprechen – kirchliche Begleitung von Religionslehrkräften
Authors: Baumann Ulrike
Published: January 2023

Durch den Krieg in der Ukraine sind Religionslehrer:innen mit einem Dilemma konfrontiert: Viele von ihnen gehen als friedensbewegte Christen von der Möglichkeit einer friedvollen Koexistenz in der Welt aus und erleben gleichzeitig einen Bruch des Völkerrechts in Europa, der auch ihre Schüler:innen mit gravierender Angst belastet. Der Artikel zeigt auf, wie kirchliche Fortbildung Religionslehrer:innen in dieser komplexen Situation begleiten kann, und wertet dazu friedenspädagogische Erfahrungen aus. Er nimmt die Diskussion um den gerechten Frieden als Leitbild in der neuen Weltlage als Orientierungsrahmen auf. Es zeigt sich, dass trotz bleibender Spannungen Kompetenzen gefördert werden können, die angesichts des Kriegs heute zur Friedensfähigkeit nötig sind.
Retromer oligomerization drives SNX‐BAR coat assembly and membrane constriction
Authors: Gopaldass Navin , De Leo Maria Giovanna , Courtellemont Thibault , Mercier Vincent , Bissig Christin , Roux Aurélien , Mayer Andreas
Published: January 2023

Proteins exit from endosomes through tubular carriers coated by retromer, a complex that impacts cellular signaling, lysosomal biogenesis and numerous diseases. The coat must overcome membrane tension to form tubules. We explored the dynamics and driving force of this process by reconstituting coat formation with yeast retromer and the BAR‐domain sorting nexins Vps5 and Vps17 on oriented synthetic lipid tubules. This coat oligomerizes bidirectionally, forming a static tubular structure that does not exchange subunits. High concentrations of sorting nexins alone constrict membrane tubes to an invariant radius of 19 nm. At lower concentrations, oligomers of retromer must bind and interconnect the sorting nexins to drive constriction. Constricting less curved membranes into tubes, which requires more energy, coincides with an increased surface density of retromer on the sorting nexin layer. Retromer‐mediated crosslinking of sorting nexins at variable densities may thus tune the energy that the coat can generate to deform the membrane. In line with this, genetic ablation of retromer oligomerization impairs endosomal protein exit in yeast and human cells.
Whole-exome sequencing of rectal neuroendocrine tumors
Authors: Li Yuanliang , Guo Yiying , Cheng Zixuan , Tian Chao , Chen Yingying , Chen Ruao , Yu Fuhuan , Shi Yanfen , Su Fei , Zhao Shuhua , Wang Zhizheng , Luo Jie , Tan Huangying
Published: January 2023

The genetic characteristics of rectal neuroendocrine tumors (R-NETs) were poorly understood. Depicting the genetic characteristics may provide a biological basis for prognosis prediction and novel treatment development. Tissues of 18 R-NET patients were analyzed using whole-exome sequencing. The median tumor mutation burden (TMB) and microsatellite instability (MSI) were 1.15 Muts/MB (range, 0.03–23.28) and 0.36 (range, 0.00–10.97), respectively. Genes involved in P53 signaling, PI3K-AKT signaling, DNA damage repair, WNT signaling, etc. were frequently altered. Higher TMB (P = 0.078), higher CNV (P = 0.110), somatic mutation of CCDC168 (P = 0.049), HMCN1 (P = 0.040), MYO10 (P = 0.007), and amplification of ZC3H13 (P < 0.001) were associated with shorter OS. Potentially targetable gene alterations (PTGAs) were seen in 72% of the patients. FGFR1 amplification (22%) was the most common PTGA followed by BARD1 and BRCA2 mutation (each 17%). As for gene variations associated with the efficacy of immune checkpoint blockade (ICB), FAT1 alteration (39%) and PTEN depletion (28%) were commonly observed. In conclusion, frequently altered oncogenic pathways might contribute to the development and progression of R-NETs. Gene alterations significantly associated with prognosis might be potential novel targets. Targeted therapy might be a promising strategy as targetable alterations were prevalent in R-NETs. FAT1 alteration and PTEN depletion might be the main genetic alterations influencing the response to ICB besides overall low TMB and MSI in R-NETs.
ROMOLEROUX: CONSCIENCIA DE HUMANIDAD DESDE EL DESNUDO FEMENINO
Authors: Palacios Guevara Karina
Published: January 2023

Hoy, al cabo de seis meses de ese primer diálogo, tenemos oportunidad de ahondar en el tema, y de recoger sus percepciones acerca del camino recorrido por la obra, sí, pero también de la expansión del propio Antonio durante ese trayecto.¿Por qué afirmas que la serie “El mensaje de las modelos a la humanidad” es la voz de los seres silenciados?Es importante profundizar en el concepto de la serie porque, aparentemente, el público no alcanza a distinguir la dimensión de la propuesta, ya que el nombre confunde un poco y, estéticamente también, porque mucha gente no alcanza a leer los mensajes de las modelos. La serie no solamente es el mensaje de las modelos, sino que habla sobre los derechos humanos y el derecho de tener un espacio para tener voz y hablar sobre otros derechos de otros seres, de otras personas. Quiénes son: son los seres que han sido violentados y no han podido expresar su trauma. Son, por ejemplo, las niñas, las mujeres, los hombres abusados sexualmente, y aquellos que tienen que trabajar sin derechos verdaderos, como buenos salarios, vacaciones, seguros médicos y de vida, que sean realmente accesibles y de buena calidad. Se habla también de temas político-ambientales, sobre los derechos de la naturaleza; la naturaleza también está siendo silenciada, con fuego, por ejemplo. La irresponsabilidad y corrupción de las autoridades, en el caso de la minería, y en el caso de la tala de árboles en la amazonia, para dar paso a terrenos para la siembra del monocultivo de soya que servirá de alimento al ganado de la industria cárnica (su voz es firme, honda, empática).
Polymers that strengthen never-dried joints between wet cellulose surfaces – A review
Authors: Pelton Robert H. , Yang Dong , Gustafsson Emil
Published: January 2023

Forming an adhesive joint between two wet cellulose surfaces before a drying step is important when manufacturing paper, foams, aerogels, other novel materials from wood pulp fibers, and various types of nanocellulose. This paper reviews the literature with an emphasis on the role of adhesive polymers on wet cellulose adhesion. Linkages between the organization of adhesives between the bonded surfaces and the strength of joints are emphasized. Relevant adhesion results from the surface forces apparatus, colloidal probe atomic force microscopy, paper wet-web strength, and wet-peeling of laminated regenerated cellulose membranes are considered.
Calificación crediticia psicométrica y su influencia en la rentabilidad de un banco: Crédito Emprendedor 2018-2020
Authors: Rojas Babilonia José Antonio
Published: January 2023

La presente investigación tiene como objetivo determinar si la calificación crediticia psicométrica en el proceso de otorgamiento del crédito a microempresarios influye en la rentabilidad de una entidad bancaria, especializada en microfinanzas. Esta investigación es de tipo aplicada, explicativa y correlacional, de diseño no experimental y enfoque cuantitativo. La muestra estuvo conformada por el número de operaciones de calificación crediticia psicométrica realizadas a microempresarios como parte del servicio “Crédito Emprendedor” en las sucursales de Villa María, Huaycán, Cajamarca, Cusco, San Hilarion y Santa Anita de la entidad bancaria. Los resultados finales permitieron establecer que la eficiencia influye de manera directa en el margen financiero bruto y neto, lo cual se corrobora con sus coeficientes 354.845 y 372.524, correspondientemente. Asimismo, estos resultan ser estadísticamente significativos (con un p-value = 0.000 en ambos casos). Por otra parte, los resultados son diferentes para la eficacia, ya que esta influye en el margen operacional neto, lo cual se refleja en su coeficiente 61.358. Igualmente, este resultado es estadísticamente significativo (p = 0.044). En conclusión: existe una relación directa y significativa entre la dimensión eficiencia y la calificación crediticia psicométrica en el proceso de otorgamiento del crédito a microempresarios, y los márgenes financieros brutos y netos de la entidad bancaria. Además, existe una relación directa y significativa entre la dimensión eficacia y la calificación crediticia psicométrica en el proceso de otorgamiento del crédito a microempresarios y el margen operacional neto de la entidad bancaria, en el periodo 2018-2020.
Control ciudadano del gasto público y social de la Contraloría General de la República, 2021
Authors: Urbina Kcomt Sheyla Mitsue
Published: January 2023

Objetivo: analizar de qué manera el control ciudadano del gasto público se relaciona con el control social de la Contraloría General de la República en Áncash, 2021. Material y Método: el enfoque fue esencialmente cuantitativo, el tipo de estudio se estableció como aplicada científica, de nivel descriptivo-correlacional (explicativo) y, todo ello bajo un diseño no experimental-transversal. La población de estudio la conformaron sujetos que son objeto de control social. Así, la muestra establecida fueron 26 trabajadores públicos de la Unidad de Control Social de Ancash y 100 personas de la población de Ancash. Esta se definió en función al muestreo no probabilístico por conveniencia y a los siguientes criterios: tipo de muestreo, población asociada al problema observado y criterios de integración y excepción. La técnica para recolectar la data clave que se utilizó fue la encuesta, mientras que los instrumentos utilizados fueron cuestionarios cerrados con escala de Likert multinivel. Resultados: el análisis inferencial correlacional bajo el modelo de contrastación de Spearman develó que, el valor p (Sig Bilateral) fue de “0,000”, por consiguiente, no se rechazó la hipótesis del investigador. Asimismo, el coeficiente ρ (rho) de Spearman mostró un valor de 0,834; esto significa que existe una asociación bidireccional directa y alta. Conclusión: la evidencia estadística fue lo suficientemente consistente para concluir que existe una asociación representativa entre el control ciudadano del gasto público y el control social de la Contraloría General de la República, 2021; para este caso en concreto.
Editorial
Authors: Editor Equipo
Published: January 2023

La revista de investigación “Gestión en el Tercer milenio” de la Facultad de Ciencias Administrativas de la Universidad Nacional Mayor de San Marcos tiene el placer de presentar su número 50 del volumen 25. Son veinticinco años de un gran esfuerzo por parte de nuestras autoridades, el comité editor y el equipo que integra la Unidad de Investigación, para publicar trabajos de investigación. Además, es a través de estos manuscritos que esperamos contribuir con las expectativas de la comunidad científica y académica; dando visibilidad a las investigaciones de nuestros docentes, graduados de maestrías y doctorado, estudiantes, así como colaboradores nacionales e internacionales. Cumplimos siete semestres que nuestra revista se encuentra indexada en Latindex Catálogo 2.0 desde el número 46 del volumen 23 del segundo semestre del año 2020; por lo que es importante mencionar que seguiremos posicionándonos en mayores niveles de estándares internacionales, para mejorar la calidad de nuestra revista y la visibilidad de nuestros artículos; eso es tarea de todos.
Surgical Treatment of Finger Degloving Injuries Without Usable Skin: a Case Report and Literature Review
Authors: Stulpinas Agnius , Venciūtė-Stankevičė Rūta , Jakutis Nerijus
Published: January 2023

The treatment of avulsion injuries of the fingers is complicated by the lack of universally accepted treatment guidelines and the wide variety of reconstruction techniques. The aim of this paper is to present a case and review the scientific literature to provide clear criteria for amputation and reconstruction and to present and discuss the reconstruction techniques with the best results.
Challenges of Epidural Hematoma Treatment after Cranioplasty: Case Report and Review of the Literature
Authors: Žalalytė Živilė , Šustickas Gytis
Published: January 2023

Cranioplasty has its risks and complications as all surgical procedures. Treatment of complications are poorly known and could raise significant challenges. One of these complications is epidural fluid collection (EFC). We presented a case of recurrence EFC with deterioration of consciousness. A decompressive craniectomy was performed after rotten subdural hematoma and craniectomy so a cranioplasty was done after more than a half year of cured infection. An EFC occurred next day and one month after the cranioplasty. Due to many repetitive surgeries and head computed tomography scans a vacuum drainage system was formed. After twelve days of treatment the patient improved and the EDC disappeared with this system. We tried to search possible causes and treatment methods for EFC in literature. However, the pathogenesis is still unknown and treatment is only symptomatic.
Extranodal Diffuse Large B-Cell Lymphoma of the Small Bowel in Female Patient Causing Intestinal Obstruction: A Case Report
Authors: Nikolovski Andrej , Trajkova Sanja , Dukovski Dushko , Spirov Goran , Petrushevska Gordana
Published: January 2023

Diffuse large B cell lymphoma is the most common extranodal non-Hodgkin lymphoma of the small intestine accounting for more than 50% of cases. Forty percent of these cases initially present with small bowel obstruction. Therefore, the diagnosis is usually established after surgery for bowel obstruction. The treatment is then continued with a certain chemotherapy regimens. We present a case of a 46-years-old female patient with signs of small bowel obstruction due to previously undiagnosed diffuse large B-cell lymphoma. Postoperatively, the patient was treated with 7 cycles of R-CHOP protocol and complete response was achieved in the short follow-up period.
Characteristics of Non-Muscle Invasive Bladder Cancer (NMIBC) in Patients Treated in an Indonesian Tertiary Hospital from 2008 to 2019
Authors: Safriadi Ferry , Palgunadi I Nyoman
Published: January 2023

Bladder cancer is the 10th most common cancer in both males and females with a ratio of 3:1. About 75% of bladder cancers are non-muscle invasive bladder cancers (NMIBC). The aim of this study was to identify the characteristics of Non-Muscle Invasive Bladder Cancer (NMIBC) patients treated in Dr. Hasan Sadikin General Hospital as one of the tertiary hospitals in Indonesia. This was a retrospective descriptive study that involved reviewing the medical records of patients diagnosed with NMIBC between January 2008 and December 2019. Characteristics reviewed were age, gender, body mass index (BMI), smoking history, urinary tract infection and stone history, intravesical chemotherapy and its side effects, and urinary cytology results. All data were tabulated and charted. Fifty-one out of 773 bladder cancer patients were diagnosed with NMIBC (6.59%). The mean age was 62.94 years old, with the majority of patients were in the 60-69 age group (31.37%). Males constituted the majority of the patients (n=44, 86.27%), with most patients had ideal BMI (66.66%), smoking history (72.54%), urinary tract infection history (56,86%), and urolithiasis history (5.88%). Thirty patients were given intravesical chemotherapy (58.82%), three patients experienced hematuria (10%), and four patients had painful urination (13.33%). Urinary cytology showed atypical cells (92.16%) in the majority of patients. The incidence of NMIBC in bladder cancer patients in our study was 6.59%, which differs from the incidence in developed countries of 75%, as shown in previous literature.
Neurotoxicity of Chlorpyrifos, Carbofuran, and Cypermethrin in Adolescent Rats’ Brain
Authors: Narwanto Muhammad Ihwan , Purwandhono Azham , Sofiana Kristianningrum , Febianti Zahrah , Putri Elvia Rahmi Marga , Jauhani Muhammad Afiful
Published: January 2023

Chronic exposure to insecticides, even at low levels, has led to chronic neurotoxicity. Adolescent brain is still undergoing important developments, including in the hippocampus. This study investigated neurotoxicity effects of subacute exposure to chlorpyrifos, carbofuran and cypermethrin in the brain of adolescent rats. This study was performed at the Histology, Biochemistry, and Animal House Laboratory of Jember University from November to December 2021. Subjects were divided into five groups: normal, control, chlorpyrifos, carbofuran, and cypermethrin. Short-term memory was evaluated by Y maze test and tissue damage was evaluated by histological examination. Brain MDA levels were determined by thiobarbituric acid reactive substance method to evaluate the oxidative stress effect on the organ. This study showed spontaneous alternation in the Y maze test and the number of pyramidal neurons in hippocampus decreased in the cypermethrin group. There was a significant elevation of brain MDA level in carbofuran and cypermethrin groups. Thus, cypermethrin causes more severe neurotoxicity than carbofuran and chlorpyrifos. Improvements in the insecticide application management are urgently needed to prevent neurotoxicity.
BMI and TLC increase Neoadjuvant Chemotherapy Response in Patients with Locally Advanced Breast Cancer
Authors: Priyono Sasongko Hadi , Putra Oscar Tri Joko , Yasmina Alfi , Poerwosusanta Hery , Rahman Eka Yudha , Oktaviyanti Ika Kustiyah
Published: January 2023

Anthracycline-based neoadjuvant chemotherapy is the recommended therapy for locally advanced breast cancer (LABC) patients. Unfortunately, no study has reported the relationship between body mass index (BMI), total lymphocyte count (TLC), and responses to this type of chemotherapy. This study aimed to determine the relationship between BMI, TLC, and response to doxorubicin/epirubicin neoadjuvant chemotherapy in LABC patients. A retrospective cohort design was applied to medical records of LABC patients undergoing neoadjuvant chemotherapy at Ulin General Hospital Banjarmasin, Indonesia, from July to December 2021. BMI and TLC data were assessed based on the values before chemotherapy, while the chemotherapy response was measured using the RECIST 1.1 criteria after 3 cycles. Multinomial logistic regression test with 95% confidence level was used to analyze these data. The results showed that as many as 71% of patients experienced a Partial Response (PR), while 5% and 23% of the patients demonstrated Stable Disease (SD) and Progressive Disease (PD), respectively. Each increase in BMI of 1 kg/m2 was significantly associated with an increase in the occurrence of PR and PD by 1.26 times and 1.29 times, respectively, when compared to the occurrence of PD. Meanwhile, an increase in TLC of 100 cells/mm3 was associated with an increase in the occurrence of PR by 6.83 times and an increase in the occurrence of SD. of 6.94 when compared to the occurrence of PD. Therefore, there is a significant relationship between BMI, TLC, and response to anthracycline-based neoadjuvant chemotherapy in LABC patients
Factors Associated with Mortality in COVID-19 Patients Treated at Serui General Hospital, Papua Indonesia
Authors: Baihaqi Fahri Ahmad , Rumaropen Henny
Published: January 2023

Coronavirus Disease 2019 (COVID-19) has a high fatality rate and has caused around 4,771,408 deaths worldwide as of 30 September 2021. COVID-19 infection presents various severity levels, starting from asymptomatic to severe symptoms that lead to death. Mortality in COVID-19 patients is associated with multiple risk factors. This study aimed to analyze the risk factors associated with COVID-19 mortality in Serui General Hospital, Papua, Indonesia. A cross-sectional analytic observational study was performed in Serui General Hospital from September 2020to September 2021. Subjects were COVID-19 positive inpatients who met the inclusion and exclusion criteria. The independent variables were demographic characteristics, clinical manifestations, comorbidities, and lab findings, while the dependent variable was mortality. Statistical analysis was performed using chi-square test and logistic regression. This study included sixty-nine patients with 21 (30.4%) of them were non-survivors. The multivariate analysis showed that an NLR of >3.13 (OR 7.49; p=0.037; 95% CI 1.63–34.35), hypertension (OR 4.71; p=0.019; 95% CI 1.28–17.29), and age (OR 4.26; p=0.028; 95% CI 1.17–15.52) were associated with mortality in COVID-19 patients. Thus, NLR >3.13, hypertension, and age are considered to be the risk factors associated with the mortality caused by COVID-19 among patients in Serui General Hospital.
Nutmeg Extract Alters Mitochondrial Genes Regulation of Skeletal Muscle Fibers in Aging Rats
Authors: Setiawan Setiawan , Pratiwi Yuni Susanti , Lesmana Ronny , Sari Galuga Sinalusur , Ramdan Ahmad , Hartono Aldo , Fathurachman Fathurachman , Supratman Unang
Published: January 2023

Nutmeg as one of Indonesia native plants has already been used widely in herbal treatment. It has been demonstrated that nutmeg presents activities related to mitochondria functions. Nutmeg potentially has the effect of peroxisome proliferator activated receptors Υ (PPAR Υ) which contributes to myogenesis, and may alters mitochondrial homeostasis in respiration and biogenesis. In this study, how nutmeg extract alters oxidative process in skeletal muscle of aging rats was explored. Twenty aging Wistar male rats aged 80 weeks old were divided into two groups (control and nutmeg treatment). Nutmeg extract was administered for 12 weeks using a gavage. After that, the soleus muscles were collected, weighted, frozen, and stored at -800C until used. Nutmeg was observed to increase the COX1 (1.9 folds, p<0.01), COX2 (1.6 folds, p<0.05), and COXIV (2.8 folds, p<0.01) gene expressions, in parallel with increased protein carbonyl levels (1.5 folds, p<0,01). Nutmeg treatment also significantly increased the expressions of antioxidant endogen COQ7 (2 folds, p<0,01) and PDSS2 (2 folds, p<0,01) in the soleus muscle. Taken together, nutmeg extract may improve mitochondrial respiratory oxidative activities in type I aging skeletal muscle.
Entrevista com Ivan Marques
Authors: Nascimento Fábio Varela
Published: January 2023

Nesta entrevista, o professor e pesquisador Ivan Marques fala sobre os aspectos relacionados à construção de João Cabral de Melo Neto – uma biografia, publicada em 2021, pela editora Todavia. Ao longo de dez respostas, Marques esclarece sua metodologia e as etapas de elaboração do trabalho, explica a convergência entre a escrita biográfica e a sua atuação acadêmica, aponta suas principais fontes de pesquisa, indica os pontos de inflexão no fazer poético de João Cabral, discorre sobre os contrastes, as relações literárias, as amizades, a vida familiar e profissional do biografado.
Technical and Economic Aspects of the Design and Production of Tank Armor in the USSR: 1930–1945
Authors: Zapary Vasily V.
Published: January 2023

Introduction, Materials and Methods. The first part of the publication is devoted to the consideration of the technical and economic aspects of the designing and production of tank armor in the USSR in 1930–1936, when the formation of Soviet tank building was taking its place. The reasons for the refusal of the country’s military industry from the mass production of heterogeneous armor and its transition to homogeneous armor are shown. The relevance of the study is due to the need to study the historical experience of the development of the Russian military industry in the context of increasing international contradiction and the transition to economic mobilization. The source base of the work consists of published research and unpublished archival documents. The study is based on traditional methods of historical analysis in the paradigm of modernization theory.

Results. The main aspects of the manufacture of tank armor during the Second Five-Year Plan are analyzed, the features of the technological process that hindered the mass production of heterogeneous armor are considered. Technological differences in the production of cemented and two-layer heterogeneous armor are shown. The reasons for the transition of the tank industry of the USSR to the mass production of homogeneous armor of high hardness are revealed.

Conclusion. The first stage in the development of armor metallurgy for the needs of the tank industry showed the economic inefficiency of using heterogeneous bulletproof armor for the forced development of tank troops. The main manufacturers of tank armor in the USSR: Izhora and Mariupol did not have enough modern equipment and qualified personnel to manufacture heterogeneous bulletproof tank armor without mass defects. The way out was found by switching these factories to the production of homogeneous bulletproof armor of high hardness.
Voluntary Donations in the Income Structure Orthodox Clergy in the Second Half of the 19th – Early20th Century (Based on the Materials of the Mordovian Region)
Authors: Shitova Tаtiana V.
Published: January 2023

Introduction. Based on the materials of the Mordovian region, one of the significant components of the income of the Orthodox clergy of the second half of the 19th – early 20th century is studied – voluntary donations. Consideration of this problem makes it possible to determine the regional aspects of the clergy’s adaptation to new socio-economic realities, which is important both theoretically and practically.

Results and Discussion. In the 1860s and 1870s, the traditional form of voluntary in-kind collection for the needs of the clergy, the ruga, was preserved in most parishes. Most of the natural fees were established by the clergy shortly after Christianization and were then broadcast as a local tradition. The basis of this collection in all villages was grain. In the 1910s, in many localities of the studied region, food collections were no longer perceived as voluntary assistance to pastors, but as extortion, which negatively affected the relationship between the flock and pastors. Among the “good deeds” of parishioners in the period under review were “mug” money – funds that church visitors donated to the needs of the clergy or for specially specified purposes. This income item, which depended both on the number of the flock and on the level of well-being of local residents, varied significantly from year to year; the size of the circle income was also influenced by the size of other public fees, yield in a specific period of time, the nature of the relationship of the flock with the clergy.

Conclusion. In the second half of the XIX – early XX century, there was a gradual replacement of natural forms of support for clerks with monetary fees. Another important trend established as a result of the reduction by many communities of traditional forms of material support for the clergy.
The Historian of Everyday Life and Household Activities, Organizer of Science and University Education: on the 85th Anniversary of V. A. Balashov
Authors: Abramova Tatiana A.
Published: January 2023

Introduction. In 2022, the 85th anniversary of the birth and the 25th anniversary of the passing away of the Soviet and Russian historian Viktor Andreevich Balashov, who made a significant contribution to the study of everyday life of the peasantry in the pre-collective farm and collective farm periods: the conditions of their personal and social life, work and leisure, the transformation of material culture, economic factors influencing the formation of consciousness and norms of behavior.

Materials and Methods. The research is based on the biographical method. The use of general scientific methods made it possible to present the studied problem as a process within the framework of a concrete historical situation, the tasks being solved, to analyze the essence and content of V. A. Balashov’s scientific, pedagogical and organizational activities. The article introduces the materials of the archives of the Ogarev Moscow State University and the Central State Archive of the Republic of Mordovia into scientific circulation.

Results. The article is dedicated to the memory of Professor Mordovia State University Viktor Andreevich Balashov. The study provides biographical information about the scientist, considers the scientific, educational, methodological, administrative activities of the scientist-historian, focuses on the analysis of the main scientific works.

Discussion and Conclusions. V. A. Balashov’s contribution to the history of the region is significant and has not been forgotten. V. A. Balashov devoted his whole life to science. From 1967 until the last days of his life, he worked at the Mordovian State University, went through a difficult path from a graduate of a small pedagogical college to the first vice-rector of Ogarev Mordovia State University, became an Honored Scientist of the Russian Federation. V. A. Balashov is the author of major works on the study of everyday life of the peasantry, ethno-cultural processes in the Volga and Ural regions, including the Mordovian people. His role as an organizer of science and university education is important.
Identificación de rizobios promotores del crecimiento vegetal asociados a garbanzo (Cicer arietinum L.)
Authors: Ortega García Marisel , Ríos Rocafull Yoania , Zelaya Molina Lily , Lara Aguilera Juan , Orteaga Garibay Ramón , Nápoles García María Caridad
Published: January 2023

Introducción. Rhizobium ha sido utilizado como estimulador del crecimiento en leguminosas. Diferentes especies de este grupo se asocian al garbanzo (Cicer arietinum L.), por lo que resulta importante obtener aislados con capacidad de beneficiar su crecimiento y productividad. Objetivo. Seleccionar e identificar aislados de Rhizobium sp. en cuanto a sus atributos como rizobacterias promotoras del crecimiento vegetal con mayor efectividad en su asociación a cultivares de garbanzo. Materiales y métodos. Los estudios se realizaron entre los años 2017-2020, en el Instituto de Investigaciones Fundamentales en Agricultura Tropical “Alejandro de Humboldt”, La Habana, Cuba. Se identificaron por secuenciación del gen 16S ARN tres cepas de rizobios, obtenidas de nódulos de garbanzo y se caracterizaron por su potencial como bacterias promotoras del crecimiento vegetal. Se realizó un experimento en condiciones de campo en dos campañas para demostrar su efectividad en la interacción con las plantas. Para los experimentos en condiciones de laboratorio se utilizó un diseño completamente aleatorizado, mientras que los ensayos en campo se realizaron bajo un diseño de bloques al azar, en ambos casos se realizó un análisis de varianza. Resultados. Las tres cepas bacterianas asociadas al garbanzo e identificadas como Rhizobium sp., fijaron nitrógeno atmosférico, solubilizaron fosfato de calcio, liberaron fitohormonas y fueron capaces de inhibir el crecimiento de Fusarium oxysporum, Fusarium incarnatum y Fusarium moniliforme. La inoculación en el garbanzo, incrementó la nodulación y las variables de rendimiento del cultivo número de vainas por planta y masa fresca de los granos (g). Conclusión. Se identificaron cepas de Rhizobium sp. con atributos como bacterias promotoras del crecimiento vegetal asociadas a cultivares nacionales de garbanzo que incrementaron su nodulación y rendimiento.