bluuebunny/crossref_metadata_2025 huggingface dataset:
Use of K-wire for fixation of lateral malleolar fractures, an alternative to plate fixation in a low resource settings
Authors: Aliyu Nuradeen Altine , Usman Ibrahim Mustapha , Zayyanu Usman
Published: June 2024

Introduction:Our objective is to describe the technique and report the outcome of intramedullary (IM) Kirshner (K) wire of lateral malleolus in the surgical management of ankle fractures. The IM fixation of the fibula has been recently introduced as an alternative to the standard open reduction and internal fixation with plates and screws, mainly for some potential complicated situations with the potential benefit of soft tissue preservation, and provision of biomechanical efficiency. Method:This is a retrospective study of Forty two consecutive patients between April 2015 and March 2022 who were managed with K wire fixation for lateral malleolar fractures. The fracture reduction was performed either percutaneously with a small pointed reduction clamp or use of longitudinal traction and rotation for closed fractures, or direct reduction in open fractures. Results:The outcome measures were mainly based on radiological and clinical evaluation during follow. Out of the 42 patients in our study, thirty four (81%) patients had good results, 5 (11.8%) fair results, and three (7.2%) had poor results using Weber subjective assessment. Conclusion:Fixation with K-wire is a viable option for the surgical treatment of lateral malleolus in ankle fractures almost similar to use of IM nail device and should be considered in the surgeon’s choice of fixation procedure particularly in a limited resource environment.
Justification of decisions regarding the water supply to the population in the mining regions in the conditions of local resources insufficiency
Authors:   M.S. Poliakov Institute of Geotechnical Mechanics of the National Academy of Sciences of Ukraine, Bubnova Olena , Babii Kateryna ,   M.S. Poliakov Institute of Geotechnical Mechanics of the National Academy of Sciences of Ukraine, Riumina Dariya ,   M.S. Poliakov Institute of Geotechnical Mechanics of the National Academy of Sciences of Ukraine, Levchenko Kateryna ,   M.S. Poliakov Institute of Geotechnical Mechanics of the National Academy of Sciences of Ukraine
Published: June 2024

The issue of the possibility of providing the population with water through the available resources of mine/quarry water formed during the extraction of minerals is considered. The authors show that there is an insufficient level of local water resources in Ukraine. The situation is especially negative in industrialized regions with high water consumption. However, in these regions, the mining industry is widely developed, and their activity is accompanied by a different level of mine workings watering. Today, mine/quarry waters are pumped out and, after sedimentation, discharged into the hydrographic network, polluting it. It is shown that the most rational is to collect, purify and use mine water. The methods of mathematical statistics were used in this work: correlation-regression and dispersion analyses, which were used to analyze data from 10 mines in the city of Kryvyi Rih over a five-year period. The annual level of water inflows, the depth of deposit development, volumes of ore extraction, areas of license areas, geological characteristics of ore deposits, etc. were analyzed. A noticeable correlation was established only between the levels of water inflows and the depth of deposit development and volumes of ore extraction. Therefore, further the multifactorial analysis of these factors was performed. During the preliminary analysis, it was established that there is a powerful dyke between the Frunze and Pokrovska mines, and the mines located on different sides of this dyke often differ in terms of water inflows. Because of this, the northern and southern groups of mines were chosen, the data for which were processed separately. The relationship between water inflows, the depth of deposit development and production volumes was analyzed according to linear and various non-linear dependencies. The exponential dependence of water inflows on the depth of deposit development and the logarithmic dependence on the volumes of extraction show the highest correlation coefficient (0.83–0.86). According to the dependencies given in the article, it is recommended to determine forecasting water inflows for the design of mine water treatment systems for drinking water supply. In the article, a general technological scheme with separate collection, sedimentation and treatment of mine waters is proposed. For the conditions of Kryvyi Rih, this will cover almost half of the population's water consumption. Keywords: water resources, mine waters, discharge, regularities, water supply, treatment.
ATP as a signaling molecule
Authors:   Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv, Babich L. G. , Shlykov S. G. ,   Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv;, Kosterin S. O. ,   Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv;
Published: June 2024

The review considers the effects of extracellular ATP mediated by plasma membrane purinoreceptors in the cells of different tissues, in particular, myometrium. Recently published results suggest that cytosolic ATP may also play a role of signaling molecule, as indicated by the detection of the ATP receptor not only in the plasma membrane, but also in mitochondria. The authors have shown that ionized Ca2+ concentration in the rat myometrium mitochondria matrix is regulated by ATP at the absence of exogenous Ca2+. ATP concentration-dependent increase of [Ca2+]m was not affected in the presence of the mitochondrial Ca2+-uniporter blocker ruthenium red, the mitochondrial pore blocker cyclosporine A, or ATP synthase inhibitor oligomycin. It is assumed that cytosolic ATP could be a signaling molecule that regulates at least the Ca2+ ions exchange in mitochondria. Keywords: Ca2+ ions exchange, extracellular and cytosolic ATP, mitochondria, P2X7 receptors
Embelin mitigates hepatotoxicity induced by isoniazid and rifampicin in rats
Authors:   Public Health Department, College of Al-Lieth Health Science, Umm Al Qura University, Makkah, Saudi Arabia, Mosa O. F.
Published: June 2024

Isoniazid and rifampicin are reliable drugs against tuberculosis, but while effective, their use is associated with the risk of drug-induced liver damage. Embelin, a natural parabenzoquinone derived from the Embelia ribes plant, has gained attention for its potential therapeutic properties, antioxidant and organ-protective effects. The study aimed to assess the hepatoprotective properties of embelin against liver dama­ge induced by isoniazid and rifampicin in rats. Wistar rats were used, and liver damage was induced by administration of isoniazid (100 mg/kg) and rifampicin (100 mg/kg). Embelin was given at doses of 50, 75, and 100 mg/kg for 21 days. All the drugs were given orally. Serum levels of the oxidative stress markers, aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP) activity measured by enzymatic assay kits (Elabscience, China), and the levels of tumour necrosis factor-α (TNF-α), interleukins IL-1β and IL-6 measured by ELISA kits (Randox, UK) were estimated. Embelin administration at varying doses effectively restored AST, ALT, ALP, SOD and catalase activity and notably decreased MDA and nitric oxide concentration as well as expression of inflammatory cytokines TNF-α, IL-1β and IL-6 in the serum of animals with drug-induced liver damage. These findings underscore embelin’s hepatoprotective effects, likely attributed to its radical scavenging properties and ability to suppress cytokine production. Keywords: antioxidant effect, cytokine suppression, embelin, hepatoprotection, isoniazid, rifampicin
Non-coding RNA NEAT-1 and interleukin-6 as diagnostic indicators for vitiligo
Authors:   Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Fayoum University, Fayoum, Egypt, Sharabi Mai M. , Zahra Amr A. ,   Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Fayoum University, Fayoum, Egypt;, Elamir Azza M. ,   Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Fayoum University, Fayoum, Egypt;, Abd El Raheem Talal A. ,   Department of Dermatology, STDs Andrology, Faculty of Medicine, Fayoum University, Fayoum, Egypt;, Aboraia Nesreen M. ,   Department of Dermatology, STDs Andrology, Faculty of Medicine, Fayoum University, Fayoum, Egypt;
Published: June 2024

Vitiligo belongs to chronic autoimmune diseases and results in a loss of functioning melanocytes and skin depigmentation. Nuclear enriched abundant transcript 1 (NEAT-1) is a long non-coding RNA that has a vital role in the diagnostics and treatment of certain autoimmune and inflammatory diseases. It is suggested that NEAT-1 can increase the pro-inflammatory cytokine level via regulatory network. The aim of the work was to measure the serum level of NEAT-1 and IL-6 in vitiligo patients compared with healthy controls and to estimate its relation to disease activity. In the study, 60 individuals were enrolled subdivided into 40 vitiligo patients and 20 healthy controls of similar age and gender. NEAT-1 expression was detected by Quantitative real-time PCR, and IL-6 level was measured by ELISA. To assess the severity of the disease Vitiligo area scoring index (VASI) was calculated. Results showed that there was a significant increase in both NEAT-1 and IL-6 levels in vitiligo patients compared with the control group. A positive correlation between NEAT-1 and IL-6 levels­ and a negative correlation between NEAT-1 level and VASI score was revealed. The elevated serum levels­ of NEAT-1 and IL-6 suggest that these circulating biomarkers have promise as diagnostic indicators for vitiligo and possible targets for therapeutic interventions. Keywords: IL-6, NEAT-1, non-coding RNA, serum, vitiligo
A grande imprensa e o “negócio da China”: Brasil e China na política externa do Governo Geisel (1974-1979)
Authors: Niches Müller Pricila
Published: June 2024

Tendo em vista que a mídia impressa é considerada um importante vetor social, ela serviu como base para esta pesquisa sobre as relações exteriores do Brasil. Procurou-se identificar como se construía nos jornais e se já era possível perceber o caráter estratégico da parceria entre Brasil e China, no seu processo embrionário, por meio da política externa brasileira, tal qual a bibliografia especializada costuma empregar para abordar a relação entre ambos os países na década de 1990. No entanto, acredita-se que a expressão “negócio da China” pode ser usada para referenciar acordos anteriores a esse período, como o estudado nesta pesquisa. Tal hipótese surgiu por se tratar de uma parceria firmada no período da ditadura civil-militar (1964-1985) no Brasil, que tinha como uma de suas características o combate ao comunismo no país, bem como a intenção de não deixar que tal ideologia se propagasse pelas Américas. Esse também era o intuito dos Estados Unidos (EUA), país pelo qual o Brasil manteve um alinhamento ideológico em boa parte de sua história.
Aspectos do projeto intelectual do Instituto Nacional de Ciência Política (1940-1945): as sessões culturais e a revista Ciência Política
Authors: Vieira Martinelli Veronica
Published: June 2024

O ano de 1940 viu surgir, na cidade do Rio de Janeiro, uma associação civil de intelectuais engajados no projeto político do Estado Novo de Getúlio Vargas. O Instituto Nacional de Ciência Política (INCP) trazia como princípios fundamentais o estudo dos problemas políticos nacionais e do pensamento dos principais estadistas brasileiros. Entretanto, ao longo dos seus cinco anos de existência, o Instituto desenvolveu e atuou dentro de um projeto intelectual bastante amplo, se destacando, sobretudo, pela difusão e propaganda da doutrina do novo regime para a sociedade brasileira da primeira metade da década de 1940.
Percepções do(s) trabalhismo(s) no periódico Correio da Manhã (1951-1954)
Authors: Chiorotti Becker Pâmela
Published: June 2024

Durante o Congresso Internacional da REFAT1, em 2022, pude contribuir apresentando um excerto de minha dissertação2, defendida em 2021. Nela buscamos delinear como os jornais Ultima Hora e Correio da Manhã colaboraram para a construção e a cristalização de sensos comuns sobre o trabalhismo e o Partido Trabalhista Brasileiro (PTB) durante o Segundo Governo Vargas. Esse recorte temporal foi escolhido devido ao intenso debate, sobretudo nos periódicos, acerca do retorno de Vargas ao poder por meio dos trâmites legais eleitorais. Além disso, é um período em que a imprensa atuou com relativa liberdade de expressão, ao mesmo tempo em que os chamados “partidos de massa” (Manin, 1995), como o PTB, iniciaram seu progressivo crescimento (D’Araujo, 1996; Delgado, 2011). Nesse contexto, a democracia se estabelecia de forma mais vigorosa, com a inserção das camadas populares urbanas na política, e os jornais discutiam ativamente o papel do trabalhismo e do PTB como doutrina e partido dedicados às novidades políticas de seu tempo.
Clitic Third in Hittite: Variation and Development
Authors: Sideltsev Andrei Vladimirovich
Published: June 2024

The paper deals with one of clitic third orders in Hittite that involves later than the expected second position of the clitic -(m)a, a contrastive conjunction and discourse marker, otherwise a standard second position clitic. -(m)a is delayed beyond its common second position by clause connectives, subordinators and conjunctions with varying obligatoriness: it is obligatory with clause connectives and optional with subordinators and conjunctions. This study explores in detail the variation with subordinators and conjunctions and it argues that clitic third order in this context is an innovation. In explaining how clitic third order was triggered in this context the etymological hypothesis of Eichner (1971, 1981) is combined with the prosodic explanation of clitic third of Kloekhorst (2014) against an alternative account of Sideltsev (2019).
Identity, Clothing, and Criminal Mobility in Early Modern Ottoman Society
Authors: Yaşa Fırat
Published: June 2024

In the early modern Ottoman Empire, social identity was closely tied to a hierarchical structure, with the sultanate occupying the highest tier and ordinary subjects positioned at the lower end. Empire’s inhabitants were divided into groups based on the style and color of their clothes. By dressing in clothing from a different gender, socioeconomic class, or ethnoreligious group, one could disguise their true identity and social status. This article endeavors to unveil the motivations that compelled ordinary people to employ clothing as a means to conceal their involvement in criminal activities. Furthermore, it investigates the constraints associated with common identity-altering practices, particularly from the vantage points of religion, gender, and intersectionality. Drawing from an array of archival sources such as mühimme records, chronicles, manuscripts, and qadi court registers, the article scrutinizes the consequences of these practices.
Defect dynamics studies during heat treatments in plastically deformed metals predicted for nuclear applications
Authors: Siemek Krzysztof , Soyama Hitoshi , Wróbel Mirosław , Liedke Maciej Oskar , Butterling Maik , Wagner Andreas , Kulczyk Mariusz , Horodek Paweł
Published: June 2024

We report on defects dynamics during heat treatment in plastically deformed metallic materials using positron annihilation lifetime spectroscopy carried out on the intense pulsed positron beam. The conducted experiment allowed us to observe the changes in the concentration and sizes of vacancy-like defects observed during in situ annealing. We monitored heat treatments up to 300 °C in hydrostatic extruded Ti and cavitation peened V–4Cr–4Ti alloy. We were able to track the recovery processes in Ti and redistribution of large voids at the surface of cavitation peened V–4Cr–4Ti alloy. The relaxation time during recovery was about 20 min. Performed experiments show that in cold-worked metallic materials significant changes in vacancy clusters concentrations occur at mildly elevated temperatures. The presented results give opportunity to the application of in situ observation of defects dynamic to similar problems related to thermomechanical processing of metallic materials.

Graphical abstract
Visualizing the Arithmetic of Complex Numbers
Authors: Soto-Johnson Hortensia
Published: June 2024

The Common Core State Standards Initiative stresses the importance of developing a geometric and algebraic understanding of complex numbers in their different forms (i.e., Cartesian, polar and exponential). Unfortunately, most high school textbooks do not offer such explanations
much less exercises that encourage students to bridge geometric and algebraic representations. The purpose of this article is to share Geometer’s Sketchpad labs, where students can unearth a geometric interpretation of the arithmetic of complex numbers and their relationship to transformations.
With dynamic technologies, students can discover that (1) addition and subtraction of complex numbers corresponds to a translation of the complex plane, (2) multiplication corresponds to a rotation and dilation of the complex plane, and (3) division of complex numbers corresponds to the composition
of a reflection about the real axis and dilation of the complex plane. Furthermore, I illustrate how such activities may potentially enrich classroom dialogue.
CATO - A General User Interface for CAS
Authors: Janetzko Hans-Dieter
Published: June 2024

CATO is a new user interface, developed by the author as a response to the significant difficulties faced by scientists, engineers, and students in their usage of computer algebra (CA) systems. Their tendency to use CA systems only occasionally means that they are unfamiliar with
requisite grammar and syntax these systems require. The author proposes CATO as a general user interface for many computer algebra systems (currently Maple, Mathematica, Maxima, MuPAD, MuPAD inside MATLAB, and Yacas).
The Future of E-Textbooks
Authors: Lokar Matija
Published: June 2024

Electronic versions of textbooks (e-textbooks) have recently become a hot topic in the educational community. A good etextbook should be quite different from a printed textbook. It should provide much more besides the obvious additions and improvements such as interactivity, multimedia,
and ease of navigation.
Using Dynamic Geometry and Computer Algebra Systems in Problem Based Courses for Future Engineers
Authors: Tomiczková Světlana , LáviČka Miroslav
Published: June 2024

It is a modern trend today when formulating the curriculum of a geometric course at the technical universities to start from a real-life problem originated in technical praxis and subsequently to define which geometric theories and which skills are necessary for its solving. Nowadays,
interactive and dynamic geometry software plays a more and more important role in this scenario as it helps to think algorithmically, enables to discuss the solvability of the whole class of geometric problems from different point of views and mainly serves as a first step to variational geometry
needed later in geometric modelling. This makes the teaching and learning process more efficient and also more interesting for students. In our contribution, we present some particular examples of this approach.
Gains and Pitfalls of Quantifier Elimination as a Teaching Tool
Authors: Oldenburg Reinhard
Published: June 2024

Quantifier Elimination is a procedure that allows simplification of logical formulas that contain quantifiers. Many mathematical concepts are defined in terms of quantifiers and especially in calculus their use has been identified as an obstacle in the learning process. The automatic
deduction provided by quantifier elimination thus allows students to exercise the formulation of concepts using quantifiers. This may be seen as conceptual modelling.
Práticas dos profissionais de saúde da atenção primária diante da hanseníase: revisão de escopo
Authors: Macêdo Michelle Santos , Barbosa Nanielle Silva , Almeida Priscilla Dantas , Melo Júlia Oliveira , Cardoso Jonas Alves , Araújo Telma Maria Evangelista de
Published: June 2024

RESUMO Objetivos: identificar as práticas dos profissionais de saúde da Atenção Primária diante da hanseníase. Métodos: revisão de escopo, realizada entre novembro de 2022 e janeiro de 2023, conduzida de acordo com a estrutura metodológica proposta pelo JBI e checklist Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews em seis bases de dados e literatura adicional. Resultados: a amostra foi composta por 11 artigos, publicados entre 2008 e 2022. Os achados foram sintetizados em três categorias: Diagnóstico precoce e tratamento oportuno; Prevenção das incapacidades físicas; e Vigilância dos contatos domiciliares e sociais. Considerações Finais: há a necessidade de alinhamento das práticas realizadas com o preconizado pelo Programa Nacional de Controle e Eliminação da Hanseníase, pois algumas não foram identificadas nos estudos, o que implica prejuízos à assistência qualificada e direcionada às demandas do cliente, com vistas ao controle e eliminação da hanseníase.
Risco Cardiovascular e Estilo de Vida: comparação entre trabalhadores do ensino de Portugal e Brasil
Authors: Toledo Noeli das Neves , Almeida Gilsirene Scantelbury de , Silva Nair Chase da , Coimbra Luana , Monteiro Sara Alves , Bitar Anna Camily Oliveira , Homem Filipa de Brito , Brito Irma
Published: June 2024

RESUMO Objetivo: Comparar o Risco Cardiovascular entre trabalhadores do Brasil e Portugal que atuam no contexto do ensino e sua relação com Estilo de Vida e Transtorno Mental Comum. Métodos: Estudo transversal que comparou as condições de saúde cardiovascular de trabalhadores do ensino de Manaus (Brasil) e Coimbra (Portugal). Foi estimada a razão de chance entre grupos. Resultados: As diferenças foram: Tabagismo e hipercolesterolemia nos participantes de Portugal. Hipertensão, doença crônica, perímetro abdominal aumentado, transtorno mental comum e afastamento do trabalho no Brasil. As variáveis com maior efeito para risco cardiovascular alto foram: País-Portugal [17.273 (IC95%1.538-193.951)], sexo-masculino [61.577 (IC95%5.398 -702.469)] e tabagismo [593.398(IC95%57.330- 6.142.020)]. Conclusão: As diferenças de risco entre grupos mostraram que os participantes de Portugal, homens, com pressão arterial aumentada e/ou tabagistas são os mais vulneráveis a ter evento cardiovascular. Há necessidades de intervenções para a promoção da saúde cardiovascular no ambiente laboral nos dois países.
Prevalence of body composition phenotypes and their associations with glycemic, lipidic, and inflammatory biomarkers: a population-based study
Authors: Nascimento Giovanna Mozzaquattro , Longo Giana Zarbato , Valmorbida Aline , Ferreira Fabrícia Geralda , Trindade Erasmo Benicio Santos de Moraes
Published: June 2024

Abstract: We aimed to verify the prevalence of body composition phenotypes and the association of glycemic, lipidic, and inflammatory biomarkers with such phenotypes. This is a cross-sectional, population-based study, with 720 participants aged 20 to 59 years. Body composition was assessed by dual-energy X-ray absorptiometry. Obesity was defined as body fat percentage ≥ 25% in males and ≥ 32% in females and sarcopenia by appendicular muscle mass index < 7.0kg/m2 in males and < 5.5kg/m2 in females. Sarcopenic obesity (SO) was defined as the presence of both sarcopenia and obesity. The prevalence of obesity, sarcopenia, and SO were 62.5%, 4.5%, and 6.2%, respectively. The association between biomarkers and phenotypes was verified using multinomial logistic regression models adjusted for confounding factors. The models showed that increased glycemia (OR = 3.39; 95%CI: 1.83-6.27), total cholesterol (TC) (OR = 2.24; 95%CI: 1.35-3.70), LDL-c (OR = 1.01; 95%CI: 1.00-1.02), VLDL-c (OR = 1.04; 95%CI: 1.02-1.06), non-HDL-c (OR = 1.02; 95%CI: 1.01-1.03), triglycerides (Tg) (OR = 3.66; 95%CI: 2.20-6.06), and decreased HDL-c (OR = 0.97; 95%CI: 0.95-0.98) were significantly associated with the obesity phenotype. Increased HOMA-IR (OR = 3.94; 95%CI: 1.69-9.21), LDL-c (OR = 1.01; 95%CI: 1.00-1.02), non-HDL-c (OR = 1.01; 95%CI: 1.00-1.02), and hs-CRP (OR = 2.42; 95%CI: 1.04-5.66) were independently associated with SO phenotype. Our findings indicate that increased glycemia, TC, Tg, LDL-c, VLDL-c, non-HDL-c, and decreased HDL-c may be indicators of the obesity phenotype and that increased hs-CRP, HOMA-IR, LDL-c, and non-HDL-c appear to be indicators of the SO phenotype. Those parameters may be used as additional markers for screening.
School, Literature and Sexual Stereotypes. A Didactic Analysis
Authors: Olay Lucía Rodríguez , Masegosa Antonio Nadal
Published: June 2024

Abstract: The purpose of the present article is to didactically analyze the responses to a questionnaire of 2,124 fifth and sixth-grade students on the subject under study. Students were asked about some gender stereotypes that appear in literary works to determine the perception that they had about them and to be able to make, in addition, a comparison between the answers of boys and girls. We focused on the results showing how the students are, in all the statements made, quite close to the answer related to agreeing with gender stereotypes, highlighting the fact that they prefer that the main characters in the books should be boys, which we could translate into future male power roles.
Hogar en pandemia: Desigualdad en tareas domésticas y de cuidado en Paraguay
Authors: Vuyk M. Alexandra , Montanía Maureen
Published: June 2024

Resumen: La desigualdad es el núcleo de discriminaciones invisibilizadas que limitan los derechos y libertades de la mujer, impidiendo su autonomía. El presente trabajo explora y analiza el alcance de dicha desigualdad en la distribución de tareas domésticas durante la cuarentena por COVID-19 en el Paraguay. Se utilizó un diseño mixto, anidado concurrente, con modelo dominante cuantitativo descriptivo-comparativo y una sección cualitativa fenomenológica. Se diseñó y aplicó una encuesta online a 1030 participantes adultos. Los resultados evidencian que las mujeres realizan la mayor cantidad de tareas domésticas y cuidado de persona/s. Las responsabilidades del hogar son un tema de discusión en la pareja. Sin embargo, ellas perciben que sus parejas las “ayudan” y ellos se perciben como más participativos a pesar de no serlo. Asimismo, las parejas LGBT reportan mayor igualdad en la distribución de tareas que las heterosexuales.
Cattle manure and humic substances improve organic bell pepper production in the Semiarid Region of Brazil
Authors: Silva Ramon F. da , Dias Thiago J. , Dias Bruno de O. , Silva Toshik I. da , Batista Diego S. , Pereira Walter E. , Sousa Valéria F. de O. , Leal Márcia P. da S. , Targino Vitor A. , Silva Ítalo L. de M. , Meneses Carlos H. S. G.
Published: June 2024

ABSTRACT Bell pepper is a globally important vegetable. The use of humic substances can enhance nutrient absorption efficiency, reducing the amounts of organic residues applied to the soil. Therefore, the objective of this study was to evaluate cattle manure rates combined with humic substance rates to increase bell pepper production. A randomized block design with four replicates was used, in a 4 × 3 factorial arrangement consisted of four cattle manure doses (8, 18, 28, and 38 Mg ha-1) and three humic substance doses (0, 8, and 12 kg ha-1). Humic substances affected bell pepper production characteristics; the highest mean fruit weight per plant (140.02 g) and fruit diameter (75.73 mm) were obtained when applying 8 Mg ha-1 of manure combined with 8 kg ha-1 of humic substances. Similarly, the greatest fruit length (80.94 mm) was found when applying 8 Mg ha-1 of manure combined with 12 kg ha-1 of humic substances. The highest yields (1.2 kg per plant and 60.14 Mg ha-1) were obtained when applying 38 Mg ha-1 of manure combined with 12 kg ha-1 of humic substances. The combination of humic substances and cattle manure increased the organic production of bell peppers under the edaphoclimatic conditions of the Semiarid region of Brazil.
Low back pain self-management mobile applications: a systematic review on digital platforms
Authors: Cargnin Zulamar Aguiar , Schneider Dulcinéia Ghizoni , Souza Michelle Gonçalves de , Vargas Mara Ambrosina de Oliveira , Tourinho Francis Solange Vieira
Published: June 2024

ABSTRACT Objective: To identify and analyze the features and quality of self-management support of mobile applications available in Brazil for chronic low back pain in adults. Method: A systematic review on the Apple Store® and Google Play® digital platforms. The Self-Management Support Assessment Tool scale was used to assess self-management support and the Institute for Healthcare Informatics Functionality Score scale was used to assess functionality. Results: Seventeen applications were selected, which included around seven self-management skills. The applications that met the majority of self-management support skills were Pathways, Branch, Pancea, Pain Navigator, and Curable. The Curable, Branch and MoovButh applications had the highest scores, with ten features on the functionality scale. Conclusion: Some applications have the potential to complement in-person treatment in terms of validity, acceptability and clinical usefulness in pain management. However, barriers such as lack of partnership between healthcare providers and patients, limited evidence-based content, social support, cultural relevance, cost, language, security and privacy can limit their sustained use. PROSPERO Registration: CRD42022382686.
Aplicativos móveis de autogerenciamento da dor lombar: revisão sistemática em plataformas digitais
Authors: Cargnin Zulamar Aguiar , Schneider Dulcinéia Ghizoni , Souza Michelle Gonçalves de , Vargas Mara Ambrosina de Oliveira , Tourinho Francis Solange Vieira
Published: June 2024

RESUMO Objetivo: Identificar e analisar os recursos e a qualidade do suporte de autogerenciamento dos aplicativos móveis disponíveis no Brasil para dor lombar crônica em adultos. Método: Revisão sistemática nas plataformas digitais Apple Store® e Google Play®. Utilizaram-se a escala Self-Management Support Assessment Tool para avaliar o suporte ao autogerenciamento e a escala Institute for Healthcare Informatics Functionality Score para avaliar a funcionalidade. Resultados: Foram selecionados 17 aplicativos, que incluíram cerca de sete habilidades de autogerenciamento. Os aplicativos que atendiam à maioria das habilidades de suporte ao autogerenciamento foram Pathways, Branch, Pancea, Pain Navigator e Curable. Os aplicativos Curable, Branch e MoovButh apresentaram as maiores pontuações, com dez funcionalidades na escala de funcionalidade. Conclusão: Alguns aplicativos têm potencial para complementar o tratamento presencial em termos de validade, aceitabilidade e utilidade clínica no manejo da dor. No entanto, barreiras como falta de parceria entre profissionais de saúde e pacientes, conteúdo limitado baseado em evidências, apoio social, relevância cultural, custo, idioma, segurança e privacidade podem limitar o seu uso sustentado. Registro PROSPERO: CRD42022382686.
Estimativa dos custos anuais da febre chikungunya no município do Rio de Janeiro
Authors: Gonçalves Thauanne de Souza , Carmo Cleber Nascimento do , Marinho Daniel Savignon
Published: June 2024

RESUMO Objetivo: Estimar o custo-doença da chikungunya no município do Rio de Janeiro no ano de 2019. Métodos: O estudo é uma avaliação econômica parcial realizada com dados secundários de acesso livre e irrestrito. Foram estimados os custos diretos ambulatoriais e indiretos das fases aguda, pós-aguda e crônica da febre chikungunya, além dos custos hospitalares. A estimativa dos custos diretos foi realizada através dos casos notificados e do fluxograma padrão de tratamento do estado do Rio de Janeiro. Os indiretos consistem na perda de produtividade e da incapacidade, utilizando o indicador de carga de doença (DALY). Resultados: O número total de casos notificados foi de 38.830. Os custos totais foram calculados em R$ 279.807.318, sendo 97% relacionados aos custos indiretos. Conclusão: A fase crônica e os custos indiretos foram os mais onerosos. A incapacidade e a permanência da chikungunya diferenciam a doença e aumentam os custos de seu tratamento.
Tuberculosis incidence in Brazil: time series analysis between 2001 and 2021 and projection until 2030
Authors: Silva Marcus Tolentino , Galvão Taís Freire
Published: June 2024

ABSTRACT Objective: To assess the incidence of tuberculosis in Brazil between 2001 and 2022 and estimate the monthly incidence forecast until 2030. Methods: This is a time-series study based on monthly tuberculosis records from the Notifiable Diseases Information System and official projections of the Brazilian population. The monthly incidence of tuberculosis from 2001 to 2022 was evaluated using segmented linear regression to identify trend breaks. Seasonal autoregressive integrated moving average (Sarima) was used to predict the monthly incidence from 2023 to 2030, deadline for achieving the sustainable development goals (SDGs). Results: There was a decrease in incidence between January/2001 and December/2014 (4.60 to 3.19 cases-month/100,000 inhabitants; β=-0.005; p<0.001), followed by an increase between January/2015 and March /2020 (β=0.013; p<0.001). There was a sharp drop in cases in April/2020, with the onset of the pandemic, and acceleration of the increase in cases since then (β=0.025; p<0.001). A projection of 124,245 cases in 2030 was made, with an estimated incidence of 4.64 cases-month/100,000 inhabitants, levels similar to those in the 2000s. The Sarima model proved to be robust, with error of 4.1% when removing the pandemic period. Conclusion: The decreasing trend in tuberculosis cases was reversed from 2015 onwards, a period of economic crisis, and was also impacted by the pandemic when there was a reduction in records. The Sarima model can be a useful forecasting tool for epidemiological surveillance. Greater investments in prevention and control need to be made to reduce the occurrence of tuberculosis, in line with the SDGs.
Consistency of information on the provision of water fluoridation in Brazil
Authors: Doalto Anna Laura Santos , Belotti Lorrayne , Paulino Camila de Moraes , Frazão Paulo
Published: June 2024

ABSTRACT Objective: This study aimed to assess the consistency of data regarding the provision of fluoridation in Brazilian municipalities with water supply systems. Methods: Official data from the National Basic Sanitation Survey and the National Information System on Sanitation for 2017 were compared. Results: Out of 5,570 municipalities in Brazil, 4,546 (81.6%) had water supply systems. The agreement between data sources was 84%, with a Kappa of 0.668, indicating substantial agreement. However, the estimates of fluoridation provision exhibited an average discrepancy of 8.1 percentage points, ranging from 1.2 points in the Central-West region to 21.4 points in the Northeast region. Conclusion: To address these inconsistencies, it is essential to enhance information sources, ensuring more reliable data for health, sanitation authorities, and society at large.
Trend and spatial pattern of intimate partner rape notifications against women in Northeast Brazil (2013–2022)
Authors: Oliveira Marília Ramalho , Madeiro Alberto Pereira , Nascimento Fernando Ferraz , Andrade Jesusmar Ximenes , Rodrigues Malvina Thais Pacheco , Mascarenhas Márcio Dênis Medeiros
Published: June 2024

ABSTRACT Objective: To analyze the trend and spatial pattern of intimate partner rape reports against women in Northeast Brazil. Methods: Ecological time-series study and spatial analysis with secondary data from the Notifiable Diseases Information System between 2013 and 2022. Gross rape rates were calculated by type of intimate partner and by age group of the victim. Prais-Winsten regression was used to calculate the trend, and the global and local Moran indices were used for spatial analysis. Results: A total of 5,542 cases of intimate partner rape were reported. Spousal rates ranged from 0.34/100,000 women in 2013 to 0.51/100,000 in 2017, with greater increases between 2018 (1.04/100 thousand) and 2022 (1.28/100 thousand). There was an upward trend in the Northeast as a whole (APC=19.47; 95%CI 15.88–23.22) and in almost all states, except Paraíba and Sergipe. Cases perpetrated by boyfriends (APC=23.90; 95%CI 12.80–36.09) and among women aged 15 to 19 years (APC=22.63; 95%CI 4.18–44.35) showed the highest annual variation. A concentration of high rates was observed in several municipalities in the northwest of Ceará and southeast of Pernambuco. Conclusion: The trend in intimate partner rape rates against women increased in the Northeast, especially among younger women and by boyfriends, with a greater agglomeration of notifications in Ceará and Pernambuco.
Monitoria de metodologia científica: relato de experiência em um componente curricular de saúde coletiva
Authors: Sanday Beatriz Herbst , Silva Fábio Tavares da , Mocellin Lucas Pitrez
Published: June 2024

RESUMO Introdução: A monitoria acadêmica é uma ferramenta complementar à construção do conhecimento dos discentes do ensino superior. Apresenta-se como mecanismo de auxílio e de orientação para os monitorados ao mesmo tempo que desenvolve as habilidades comunicacionais para além dos saberes essenciais do monitor. O presente trabalho tem como objetivo relatar uma experiência de monitoria com diferentes estratégias de ensino e de avaliação por meio de metodologias ativas, aplicando atividades teóricas e práticas interdisciplinares para estudantes de Medicina. Relato de experiência: Este relato de monitoria, realizado em um componente curricular de saúde coletiva da graduação em Medicina de uma universidade pública federal do Rio Grande do Sul, apresenta dados quantitativos e discute os conhecimentos adquiridos com a aplicação das atividades do projeto de ensino. Discussão: Analisaram-se quatro semestres, em que se compararam registros realizados em formulários on-line sem identificação dos respondentes referentes à participação das monitorias de caráter teórico e prático, sendo a maior adesão de participantes nas atividades práticas (42,31% versus 25,55%). Depreenderam-se as principais motivações dos discentes para buscar a monitoria, sendo a elucidação de uma etapa da simulação de pesquisa a mais requisitada. Houve predominância dos valores próximos ao máximo em monitorias práticas em relação às teóricas na avaliação geral delas, sendo considerados três aspectos: importância da atividade; clareza e didática da monitora; esclarecimento de dúvidas. Percebeu-se que o tempo destinado aos encontros variou de forma considerável, sendo mais frequente destinar 60 minutos às atividades teóricas e 30 minutos às atividades práticas. A comparação da proposta de atividades práticas e teóricas aplicadas por meio de metodologias ativas no projeto de monitoria evidenciou o quanto o discente, monitor ou monitorando, beneficia-se do processo de ensino-aprendizagem quando inserido como responsável principal pela própria educação. Conclusão: Na perspectiva da monitora, houve um fortalecimento das próprias competências relacionadas ao saber científico, assim como se observaram um nivelamento da turma em relação aos conteúdos de base e a progressão gradual da aquisição de um raciocínio crítico do estudante da área da saúde.
Intake and digestibility in sheep fed diets that include waste frying oil
Authors: Pantoja Sarah O. S. , Rêgo Aníbal C. do , Domingues Felipe N. , Souza Melany S. de , Souza Agatha G. F. de , Araújo Vitor de S. , Faturi Cristian
Published: June 2024

ABSTRACT Waste frying oil may serve as a viable alternative to fresh vegetable oils, potentially reducing environmental impacts and animal feed costs. This study aimed to assess the effects of incorporating waste frying oil into sheep diets and to determine the optimal dietary oil concentration. We evaluated intake and apparent digestibility using 25 uncastrated Santa Inês male sheep (average, 90 d of age; 20 ± 3.56 kg) in a randomized block design over a 21-d experimental period. The sheep were housed in individual metabolic cages and fed diets with a 50:50 roughage-to-concentrate ratio twice daily. Diets included waste frying oil at concentrations of 0, 2, 4, 6, and 8% of the total dry matter. Animals receiving higher concentrations of waste frying oil exhibited lower nutrient intake (p < 0.05) compared to those with up to 4% inclusion. Nutrient digestibility decreased linearly (p < 0.05) with increasing oil content, except for ether extract digestibility (p = 0.02), which improved. Although the addition of oil increased the concentration of total digestible nutrients, the intake of total digestible nutrients was not maintained or enhanced at 6% and 8% oil (p = 0.82). Including up to 4% waste frying oil in sheep diets is feasible without compromising nutrient intake and digestibility.
Chemical and mineral composition of the raw and cooked immature grains of cowpea genotypes
Authors: Gomes Fernanda de O. , Silva Izabel C. V. , Franco Luis J. D. , Hashimoto Jorge M. , Damasceno-Silva Kaesel J. , Rocha Maurisrael de M.
Published: June 2024

ABSTRACT Immature cowpea grains are a rich source of proteins, minerals, dietary fiber, and phenolic compounds and also have a high antioxidant capacity compared to dry grains. Its consumption promotes a healthy and diversified diet. The objective of this work was to evaluate the cooking time and chemical and mineral composition of the raw and cooked immature grains of different cowpea genotypes. Four genotypes, two elite lines (MNC00-595F-27 and MNC05-847B-123) and two commercial cultivars (BRSTumucumaque and Vagem Roxa-THE) were analyzed. Cooking time was evaluated using the Mattson cooker. Proximate composition and minerals were determined. A completely randomized design with three replications in factorial scheme 1 (genotype) × 2 (raw and cooked grains) was adopted, except for cooking quality. The genotypes MNC05-847B-123 and BRS-Tumucumaque differed from the other genotypes, presenting faster cooking of the immature grain. Cooking increased the moisture content and reduced ash, lipid, protein, and carbohydrates contents and total energy value. The lines MNC05-847B-123 and MNC00-595F-27 showed higher contents of the nutrients of the centesimal composition after cooking than the local cultivar Vagem Roxa-THE, except for the moisture content. The mineral content decreased after cooking, with Fe, Zn, and Mn contents having the least losses with thermal processing. The lines MNC05-847B-123 and MNC00-595F-27, even with losses after the thermal processing of the immature grain, have nutritional potential as cultivars for the green-bean market.
Genetic potential of maize populations derived from commercial hybrids for interpopulation breeding
Authors: Almeida Pedro H. S. , Vilela Valdinei J. B. , Torres Isabela Y. , Uberti Alison , DeLima Rodrigo O. , Reis Edésio F. dos
Published: June 2024

ABSTRACT Our objective was to evaluate the genetic potential of two maize populations derived from commercial hybrids for beginning a reciprocal recurrent selection (RRS) program. For this, 280 interpopulation half-sib (HS) progenies were produced from two populations (140 HS from each population), which were derived from the selfing of the commercial hybrids AS1598 (Pop1) and RB9210 (Pop2). We then evaluated the 280 HS progenies, the two base populations, and the two hybrids for grain yield (GY) and ear and plant architecture traits in southwestern Goias during the 2020 winter season. Variance components and genetic values of each progeny were estimated using the REML/BLUP (Restricted Maximum Likelihood/Best Linear Unbiased Prediction) methodology. Genetic gains by selection of the top 20% of progenies were predicted using two strategies: i) selection for GY and ii) selection for GY and days to silking (DTS) simultaneously. We observed genetic variability in both populations for all tested traits; therefore, it is possible to obtain genetic gains from the interpopulation improvement of both Pop1 and Pop2. The genetic gain estimates with the selection based on GY were 9.03 and 3.45% for Pop1 and Pop2, respectively. Simultaneous selection for GY and DTS resulted in positive (>4%) genetic gains for GY in both populations and decreased the cycle in Pop1, but we did not observe any alteration of the cycle in Pop2. We concluded that both populations derived from commercial hybrids have genetic potential for interpopulation improvement using RRS.
In vitro effect of polar extracts from Annona glabra seeds on Fusarium solani
Authors: Martínez Oscar M. M. , Rivera Ana I. G. , Álvarez Gloria E. G. , Osorio Norma P. D. , Hurtado Nathalia C.
Published: June 2024

ABSTRACT Fusarium species are the cause of diseases in various crops throughout the world and cause significant economic losses. Chemical fungicides are the main strategy for control, but their intensive and long-term use generates resistance, toxic residues, and environmental contamination. The biological control of bioactive substances has wide applications. In this study, the fungicidal activity of the extract obtained from Annona glabra L. seeds was evaluated as a control alternative for Fusarium solani. In addition, chemical characterization was carried out to identify the groups of metabolites present in the extract. The fungicidal activity against F. solani was evaluated using the microdilution method, and the minimum inhibitory concentration (MIC) was established, as well as the mean inhibitory concentration (IC50). The IC50 of the extract was 972.24 mg L-1, and the MIC was 12.02 mg L-1. Using chemical characterization by ultrahigh-efficiency liquid chromatography coupled with mass spectrometry, the presence of THF acetogeniones, isoquinolinic alkaloids, and kaurene-type diterpenes, which were the main compounds responsible for the activity evaluated, was confirmed. The results obtained provide evidence that A. glabra seed extracts can be a potential source of metabolites with fungicidal activity.
Seedling biometrics and relationship with yield of physalis
Authors: Machado Josué P. , Cecílio Filho Arthur B. , Mendonça Andrea V. R. , Souza Josival S. , Souza Manuela O. de
Published: June 2024

ABSTRACT Physalis angulata has fruits rich in vitamins A and C, phosphorus, iron and antioxidant substances, while its leaves and roots have physalins, of high pharmacological potential. However, its cultivation is recent and there is a lack of technical knowledge. Characteristics of the seedling determine its vigor and the time of transplantation, which affect the performance of the crop in the field and, consequently, its yield. Therefore, the objective of this study was to know the influence of seedling height and stem diameter on the yield of P. angulata, defining the standard for transplantation and the time of permanence in the nursery. To obtain biometric characteristics, P. angulata was sown every four days and the seedlings were transplanted on April 6, 2022, at 22, 26, 30, 34 and 38 days after sowing. Descriptive analyses of the seedlings in the nursery were performed, with evaluations at 14, 18, 22, 26, 30, 34 and 38 days after sowing. To assess the performance of seedlings in the field, the 300 seedlings of different sizes transplanted were evaluated for survival and number of fruits per plant (< 150; 150 to < 200; 200 to < 250 and ≥ 250 fruits). For more productive plants (≥ 200 fruits), P. angulata seedlings should remain in the nursery for 38 days after sowing, when they will have at least 12.8 cm in height and 4.2 cm in stem diameter.