bluuebunny/crossref_metadata_2025 huggingface dataset:
Returning to non-entailed presuppositions again
Authors: Zehr Jérémy , Schwarz Florian
Published: January 2021

Recent work by Sudo (2012) and Klinedinst (2016) proposes a new perspective ondifferences between classes of presupposition triggers, with an empirical split roughly mirroringAbusch’s (2002) hard vs. soft distinction and related notions. These two authors proposethat triggers differ in whether or not their presuppositional content simultaneously affects thecalculation of the presuppositions and of the entailments of the sentences in which they appear.Drawing on a proposal by Glanzberg (2005) we formulate the Removability/Independence Hypothesis:triggers that do not affect entailments are triggers that can be left out of sentenceswithout affecting interpretability. We experimentally test the hypothesis by embedding return,(go) again and (go) back in non-monotonic environments, which Sudo argues to elicit differencesin presuppositions and entailments. Our results provide clear evidence against the RIhypothesis: whereas only the trigger return is crucial for the sake of interpretability, all threetriggers produced similar results. At the same time, data for the triggers stop and also, includedas controls, lend further support in favor of Sudo’s entailment-contrast proposal.Keywords: presuppositions, entailment, hard/soft distinction.
Narrative texts by children and adults
Authors: Weber Oliver , Lindgren Josefin , Gagarina Natalia
Published: January 2021

ZASPiL 62.2019 contains 10 articles.
Introduction to MAIN – Revised, how to use the instrument and adapt it to further languages
Authors: Bohnacker Ute , Gagarina Natalia
Published: January 2021

...
The adaptation of MAIN to Estonian
Authors: Argus Reili , Kütt Andra
Published: January 2021

This paper describes Estonian version of the Multilingual Assessment Instrument for Narratives (LITMUS-MAIN) to Estonian. A short description of Estonian, some challenges in the adapting MAIN to Estonian, the first experiences of using the Estonian MAIN and a summary of the first results are presented.
Multilingual Assessment Instrument for Narratives (MAIN) adapted for use in West Frisian
Authors: Bosma Evelyn , Dijkstra Jelske
Published: January 2021

This paper describes the current state of affairs concerning the West Frisian adaptation of the Multilingual Assessment Instrument for Narratives (MAIN). We provide a short description of the West Frisian language, the process of adapting MAIN into West Frisian and the results of recent research using this adaptation.
Adapting MAIN to Irish (Gaeilge)
Authors: O’Malley Mary-Pat , Antonijevic Stanislava
Published: January 2021

Irish (Gaeilge) is the first official language of the Republic of Ireland. It is a fast-changing, endangered language. Almost universal bilingualism (i.e. almost all Irish speakers also speak English), frequent code-switching to English, and loan words are features of the sociolinguistic context in which the language is spoken. This paper describes the adaptation of the Language Impairment Testing in Multilingual Settings - Multilingual Assessment Instrument for Narratives (LITMUS-MAIN, Gagarina et al., 2019) to Irish. Data was collected using the retell mode (Cat story) and the comprehension questions. Eighteen children participated ranging in age from 5;3 to 8;7 (six female and 12 male). Results suggest that story structure is not sensitive to exposure to Irish at home and indicate that MAIN Gaeilge (Irish) is a promising tool for assessing language in Irish- speaking children from a range of Irish language backgrounds.
Italian adaptation of the Multilingual Assessment Instrument for Narratives
Authors: Levorato Chiara , Roch Maja
Published: January 2021

This paper presents the Italian version of the Multilingual Assessment tool for Narratives (MAIN), describes how it was developed and reports on some recent uses of MAIN within the Italian context. The Italian MAIN has been used in different research projects and for clinical purposes; results have been presented at conferences and in peer reviewed papers. The results indicate that MAIN is an appropriate assessment tool for evaluating children’s narrative competence, in production and comprehension from preschool age (5 years) to school age (8 years) in typical language development, bilingual development and language delay/disorders.
The Multilingual Assessment Instrument for Narratives (MAIN): Adding Urdu to MAIN
Authors: Hamdani Saboor , Kan Rachel , Chan Angel , Gagarina Natalia
Published: January 2021

The Multilingual Assessment Instrument for Narratives (MAIN), an assessment tool in the Language Impairment Testing in Multilingual Settings (LITMUS) battery, aims to improve the assessment of bilingual children. This paper describes the process of adapting MAIN to Urdu. Given the lack of language assessment tools for Urdu-speaking children, the Urdu MAIN is an important new instrument that is made widely and freely accessible to researchers and practitioners, allowing them to examine the narrative abilities of children acquiring Urdu as a first, heritage, second, or additional language.
PATIENT PERCEPTION OF ONCOLOGY CARE DURING THE COVID-19 PANDEMIC: A PROSPECTIVE OBSERVATIONAL STUDY FROM MOROCCO
Authors:   Mohammed VI University of Health Sciences (UM6SS).Casablanca, Morocco.Department of Radiotherapy, International University Hospital Sheikh Khalifa., Kouhen F. , Chihabeddine M. ,   Mohammed VI University of Health Sciences (UM6SS).Casablanca, Morocco.Department of Radiotherapy, International University Hospital Sheikh Khalifa.
Published: January 2021

Background:The first case of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in Morocco was detected in Casablanca on March 2, 2020 since then, our country has implemented restrictions on population movement to slow the spread of the virus. The management of cancers must be adapted to this context. Materials and methods:All patients who are treated At the Radio-Oncology Unit of the Sheikh Khalifa Hospital at Casablanca were included in this prospective observational study for a questionnaire-based survey to evaluate the worries and perceptions of patients about changes and delays in their treatments during covid-19 Pandemic Results:Total of 53 cancer patients participated in this study. The majority of patients possess adequate knowledge and practice appropriate preventive actions. However, they expressed their negative emotions and worries about the impact of changing their treatment on the prognosis of the disease and they considered cancer more deadly than covid-19. Conclusion:The present study shows the need to look for other solutions that ensure continuity of care such as telemedicine, while reducing exposure for health care workers and other patients without affecting the prognosis of their disease.
SIMULATION MODELING OF THE INTERFERENCE IMMUNITY OF THE RADARS OPERATING WITH COMPRESSED SIGNAL
Authors:   Logistics Department, Command and Staff Faculty,Rakovski National Defense College, 1504 Sofia, Bulgaria., Ivanov Spassov Sevdalin
Published: January 2021

The immunity to the interference of a radar operating with a pulse compression signal is an important feature. The matched filter is one of the elements of the radar, providing resistance to interference. A model of a matched filter to chirp signal has synthesized using the Simulink tool of the Matlab software. Two types of interference signals have fed to the matched filter input, and the output signals are measured. The matched filters degree of suppression against these two interference signals has been assessed. Inferences about the interference immunity of the radars operating with compressed signals have been made.
ROLE OF PREOPERATIVE EPIDURAL ANALGESIA IN POSTOPERATIVE OUTCOME OF PATIENTS WITH CHRONIC LIMB ISCHEMIA AND REST PAIN
Authors:   Senior Assistant Professor, Institute Of Anaesthesia and Critical Care, RGGGH- Madras Medical College,Chennai., Deepthi P.
Published: January 2021

Introduction:Rest pain in patients with chronic limb ischemia is very severe and intolerable one, hence it is often quoted as cry of dying nerves. All these patients require highly effective analgesia for control of pain. Epidural analgesia is known for its effective analgesic property. Its role in post operative period is well documented and known. But its role in preoperative period for these patients is poorly understood. Here we analyze role of preoperative epidural analgesia in postoperative outcome of patients with chronic limb ischemia and rest pain. Material and Methods:It is a prospective study done in 40 patients which analyze role of preoperative epidural analgesia in postoperative outcome of patients with chronic limb ischemia and rest pain who are undergoing bypass revascularization procedures. Here 20 patients each separated in two groups, group 1 â€“ those received preoperative epidural analgesia for 48 hours prior to surgery and group 2 those who not received preoperative epidural analgesia. Results:It was found postoperative wound infections, limb salvage rates and adverse myocardial events were lower in group 1 patients those received preoperative epidural analgesia. Conclusion:Hence preoperative epidural analgesia has beneficial role in postoperative outcome of patients with chronic limb ischemia and rest pain.
A STUDY ON DETECTION OF BACTERIAL AND FUNGAL ISOLATES IN BRONCHO ALVEOLAR LAVAGE FLUID SPECIMEN WITH A SPECIAL MENTION ON ANTIMICROBIAL SUSCEPTIBILITY PATTERN OF BACTERIAL ISOLATES
Authors: N. Sudha , R. Selvi , V. Indumathy , V Rengashini
Published: January 2021

Introduction:Chronic respiratory diseases are a group of chronic disease affecting the airways and other structures of lungs. Common causes of infections in these patients are viruses, bacteria and fungi4. Respiratory Tract Infection (RTI) is by large one of the leading causes of the morbidity and mortality in the world3. Early diagnosis and proper choice of antimicrobials is crucial for management of these patients. Aims and objectives:The Aims and Objectives of this study, is to identify the bacteriological and mycological isolates in Broncho-alveolar lavage fluid and detect antimicrobial susceptibility pattern of bacterial isolates. Materials and Methods:A total of 203 Broncho-alveolar lavage fluid in paired samples obtained from patients were analyzed.The pathogens were identified and speciated by using the set of biochemical reactions as per standard reference. Results:This prospective study was done for a period of twelve months (September 2017 to August 2018) with 203 Broncho-alveolar lavage fluid samples. Growth was observed in 115 samples (56.65%). Of the culture positive samples, 77(67%) were bacterial, 21(18%) samples were mycobacterium tuberculosis and 17 (16%) were fungal isolates. The most common bacterial isolate was Klebsiellapneumoniae (28.57%), followed by Staphylococcus species (24.64%), Escherichia coli (20.77%), Pseudomonas species (14.28%), and Acinetobacter species (11.68%). Among the Staphylococcus aureus isolates,40% were Methicillin resistant and 60% were Methicillin sensitive.The fungal isolates were Candida(35.29%),Aspergillus(29.41%),(17.64%),Penicillium(11.76%)and Paecilomyces (5.88%). Conclusion:Systematicculture of BAL fluidgives a definite diagnosis of chronic pulmonary infections which would guide in selection of appropriate antimicrobials for management of pneumonia..A study like this would help and guide the physicians in prescribing the right combinations of anti-microbial to limit and prevent the emergence of multi-drug resistant strains of Bacteria.
PREVALENCE OF VITILIGO IN KINGDOM OF SAUDI ARABIA (CROSS SECTIONAL STUDY)
Authors:   Assistant professor of family medicine, Consultant Family Medicine, Family Medicine Department, King Abdulaziz University, Jeddah., Abdulaziz Murad Manal , Jehad Abousada Hoda ,   Jeddah, 22338., Hassan Alluhaybi Abdulelah ,   General physician, KSA., Abdulmohsen Almohammadi Adeeb ,   General physician, KSA., Ahmed S Shaman Salem ,   General physician, KSA., Wael Khayat Ghaida ,   General physician, KSA., Hussein T. Sulimani Sanaa ,   Medical intern, KSA., Salamah Alanazi Maali ,   Medical intern, KSA., Abdulhaq Albloshi Sahar ,   Medical intern, KSA., Mohammed Al. Modeer Shaima ,   Medical intern, KSA., Ibrahim Alhabib Asma ,   Medical intern, KSA., Misfer M. Alzahrani Hanan ,   Medical intern, KSA., Magdi M. Hassanin Majdolen ,   Medical intern, KSA., Abdullah Aldugman Maha ,   Medical student, KSA., Ahmad A. Assiri Alwah ,   Pharmacist, KSA.
Published: January 2021

Background:Vitiligo is acquired condition of skin and hair depigmentation that characterized by the appearance of pale macules or hypochromic pigment. Vitiligo is not a life-threatening situation however it affects patients health-related quality of life and psychological well-being. Therefore, in this study, we aimed to prevalence of vitiligo in Saudi population besides, Most common place of first spot of vitiligo, and the relationship between some medical conditions and vitiligo. Methodology: This is an analytical cross-sectional study conducted in kingdom of Saudi Arabia (General population and vitiligo patient) from 04/08/2020 till 22/11/2020. The study was depending on using of online questionnaire assessing demographic factors including age and nationality besides disease-related information: Heart disease, Smoker patient, related risk factors of disease and DM patient. Results: We had received 875 responses of our questionnaire, where the prevalence of vitiligo was 3.5 % where 51.6 % of them were male. Moreover, 51.6 % of them were below 25 years old, 19.4 % were between 25 â€“ 30 years old and 12.9 % were between 31 â€“ 35 years old. Furthermore, most of them were Saudi Arabian (93.5 %).Moreover, most of patients indicated that they were patients with vitiligo for more than 5 years (61.3 %) while the first spot of vitiligo was above eyes (22.6 %), hands (19.4 %), Armpits (12.9 %) and knee (12.9 %) Conclusion:We had found that the prevalence of vitiligo in Saudi Arabia was high than reported by other studies where male are slightly more affected by the diseases and those of younger age. Face and hand are the most common spots of vitiligo. Moreover, smoking, diabetes mellitus and thyroid disorders may have effect in increased incidence of vitiligo.
Antecedents of behavioral intention to use online food delivery services: an empirical investigation
Authors: P Vinish , Pinto Prakash , Thonse Hawaldar Iqbal , Pinto Slima
Published: January 2021

The online food delivery market in India perseveres to grow at a sustained pace. The business has unique dynamics and challenges with the spike in orders during weekends, meeting delivery schedules during peak demand, offering deep discounts to address wavering customer loyalty, reducing cash burns, and managing food quality inconsistency. In contrast, the fast-paced life and the rise of millennials in the workforce is likely to assure a promising future for the food aggregators. The above backdrop has led the researchers to pursue this study. An empirical study was carried out to explore the consumption occasion and the antecedents of online food ordering in the select cities in Karnataka, India. The data was collected from 385 respondents through telephonic and mail survey using a structured questionnaire. The responses were analyzed using exploratory factor analysis and multiple regression. The result of the study indicated a positive association between the constructs ‘buying motives’, ‘aggregator attractiveness’, and customer satisfaction. The variation in customers` satisfaction is largely attributable to the convenience of order placing, food quality, availability of food and restaurant reviews, offers and discounts, faster home delivery, and the wide choice of restaurants listed on the aggregator’s website. Additionally, the aggregator attractiveness showed a higher impact on customer satisfaction as compared to buying motives.
Key Factors to Promote Industry 4.0 Readiness at Indonesian Textile and Clothing Firm
Authors: Norman Ferly
Published: January 2021

This study discusses whether challenges, barriers, and key factors are the readiness of Indonesian Textile and Clothing (TC) firm in adopting Industry 4.0 (I4.0). The research method is by distributing questionnaires with closed questions to TC employees and owners firm. Respondents were given 15 barriers factors of adoption of I4.0 and gave weight with Likert scale method based on the situation in their company. The survey results were then tested by 2 experts from TC company executives and senior researchers from research institutes. The results of the study show that there are 5 major Barrier Factors with an average value of ≥ 4.0 ("Strongly Agree"): 1. High investments, 2. Lack of digital culture and training, 3. Lack of digital infrastructure, 4. Lack of Government regulation and support, 5. Ineffective Change Management. The key to the company's readiness to adopt I4.0 is not limited to only reducing the five barriers above, but requires two prerequisites so that the company has the financial capacity to invest in I4.0 namely; 1. Enlarge profit margins 2. Form a business ecosystem and innovation. This study is one of the first to find out the barriers of Indonesian TC companies in the implementation of I4.0. From the TOE Framework approach, this study highlights the difficulties in the diffusion of technological innovations resulting from the weak execution of national policies on I4.0 (environmental elements). The results of this study can help TC decision makers and practitioners pave the way for the successful implementation of I4.0.
Calibration of seasonal transfer equation (Z–R) by data of Doppler weather radar, rainfall gauging station and genetic algorithm method in the Abolabbas watershed (in southwest of Iran)
Authors: Adib Arash , Soori Damirchi Sofla Masoud , Mirzaei Seyed Yahya , Mahmoudian Shoushtari Mohammad , Liaghat Ali
Published: January 2021

The observed radar reflectivity (Z) converts to rainfall intensity (R) by a transfer function. In the first stage, for calibration of collected data (with time step 15 minutes) by weather radar and determination of the best relation between Z and R, it applied a genetic algorithm (GA) to minimize the amount of root mean square error (RMSE). Although Z = 166R2 (the transfer function in the Khuzestan province of Iran) is an appropriate equation, the GA method distinguished that Z = 110R1.8 (from February to May) and Z = 126R2 (for other months) are the optimum transfer functions for the Abolabbas watershed in Iran. The mean of RMSE of optimum transfer equations is 0.59 mm/hr in the calibration stage and 0.85 mm/hr in the verification stage. In the second stage, the Hydrologic Modeling System (HEC-HMS model) used four types of precipitation data (extracted rainfall data from radar and the optimum transfer equations, Z = 166R2, Z = 200R1.6 and extracted rainfall data from rainfall gauging stations). The calibrated rainfall data by the optimum transfer equations can produce flood hydrographs in which their accuracy is similar to the accuracy of generated flood hydrographs by collected rainfall data of rainfall gauging stations. The mean of RMSE is 0.65 cubic metres per second and the mean or R2 is 0.89 for optimum transfer equations.
Selenium and Computational Studies
Authors: de Sousa Natália Ferreira , Scotti Luciana , Muratov Eugene N. , Scotti Marcus Tullius
Published: January 2021

Background:

Organocalcogens are a class of organic compounds obtained by the synthesis
experiments to include S, Se, or Te. Among the elements that comprise this class, Se is characterized
as an essential mineral and nutrient for humans. Se has been widely studied in many aspects. Organic
synthesis of organoselenides is used for obtaining new potential drug candidates and may be highly
beneficial from the use of computational approaches to reduce time and cost of the experiments. Thus,
the goal of our study is to evaluate the computational approaches used in the organoselenides research
from 1999 to 2019.

Methods:

A literature review was performed by searching the database “Web of Sciences”.

Results:

Most of the theoretical studies included structural elucidation or structure-property analysis.
We also found research regarding molecular docking approaches and Quantitative Structure-Activity
Relationship (QSAR) studies.

Conclusion:

Computational studies have been widely applied to organoselenides. They demonstrated
promising results and resulted in reduced the cost of research, increased efficacy, and, ultimately,
novel organoselenides with desired properties.
Imaging Features of Thoracic Manifestations of Behçet’s Disease: Beyond Pulmonary Artery Involvement
Authors: Yazgan Çisel , Ertürk Hakan , Taşkın Ayşenaz
Published: January 2021

Background:

Behçet’s disease is a chronic multisystemic vasculitis affecting vessels of different sizes in various organs. Thoracic manifestations of the disease show a wide spectrum involving a variety of anatomic structures within the chest. However, pulmonary artery involvement is a typical manifestation of the disease that contributes significantly to mortality in patients. The study aimed to analyze CT features of thoracic manifestations, particularly pulmonary artery involvement, and to quantitatively assess bronchial arteries in Behçet’s disease.

Methods:

Patients with Behçet’s disease who underwent CT scans for suspected thoracic involvement between 2010 and 2018 were included. CT findings of 52 patients were retrospectively analyzed for thoracic manifestations of the disease. Bronchial arteries were assessed regarding diameter in patients with/without pulmonary artery involvement. The pulmonary symptoms were noted.

Results:

Of the 52 patients, 67% had thoracic manifestations including pulmonary artery involvement, parenchymal changes, superior vena cava thrombosis, and intracardiac thrombus. Pulmonary artery involvement was observed in 50% of the cohort. Peripheral pulmonary arteries (77%) were the most commonly affected branches, followed by lobar (42%) and central (35%) pulmonary arteries. Other thoracic findings were significantly correlated with pulmonary artery involvement (p<0.05). Compared to patients without pulmonary artery involvement, those with pulmonary artery involvement had a higher bronchial artery diameter (p<0.05) and occurrence rate of dilated bronchial arteries.

Conclusion:

Involvement of peripheral pulmonary arteries is frequently encountered in Behçet’s disease and it can resemble pulmonary nodules. Dilated bronchial arteries, which can be observed in cases of pulmonary artery involvement, should be considered in patients with hemoptysis.
Polymers Based on Phenyl Boric Acid in Tumor-Targeted Therapy
Authors: Luo Dexia , Yao Zheng , Wu Junzi
Published: January 2021

Background:

Tumors are still among the major challenges to human health. Tumor-targeted therapy
is an effective way to treat tumors based on precise medical models. Sialic acid (SA) is overexpressed on the
surface of tumor cells, and Phenyl Boric Acid (PBA) can specifically bind to SA. However, studies on the use
of PBA in tumor-targeted therapy are few.

Objective:

To summarize and analyze the characteristics and influencing factors of tumor targeted therapy in recent
years, and the influencing factors of phenyl boric acid modified polymers in tumor targeted therapy, such
as hydrogen ion concentration (pH), Adenosine Triphosphate (ATP), and sugars. This paper describes the application
of phenyl boric acid partially functionalized nano-polymers in various types of targeted tumors, such as
breast cancer, lung adenocarcinoma, liver cancer, and so forth. In order to further improve the basic research
and clinical workers' understanding of nano-preparations and tumor targeted therapy. At the same time, it is also
expected to promote the development value of phenyl boric acid.

Methods:

The findings on tumor-targeted therapy and the role of partially functionalized polymers with PBA in
different tumors at home and abroad has been analyzed and summarized in recent years.

Results:

Tumor-targeted therapy is a promising treatment for tumors. PBA promotes the treatment of tumors using
SA, which is highly expressed on the surface of tumor cells.

Conclusions:

Tumor-targeted therapy has shown great prospects for clinical application in recent years. PBA is
beneficial as a member of the drug loading system. Further studies are still needed to promote its development
and application.
Design and Synthesis of Tetrahydroisoquinoline Derivatives as Anti-Angiogenesis and Anti-Cancer Agents
Authors: Gangapuram Madhavi , Eyunni Suresh , Zhang Wang , Redda Kinfe K.
Published: January 2021

Aim: :

The aim of our research work is the synthesis of tetrahydroisoquinoline derivatives as anti-Angiogenesis and anti-cancer
agents.

Background: :

Cancer is the second leading cause of deaths in United States. The current recovery rate from the advanced treatment for
the cancer is unacceptably low. Therefore, identification of novel, potent and less toxic anticancer agents remains a top priority.

Objective:

To 1) evaluate anti-angiogenesis, anticancer activities of THIQs on different colorectal cancer cell lines (CRC) viz., Colo320,
DLD-1, HCT116, SNU-C1, SW480 and GSK3b in pre-treated viability HCT116. 2) Undertake molecular docking studies of THIQs.

Methods:

Twenty synthesized THIQs were screened in the Eli Lilly’s Open Innovation Drug Discovery Program
and selected twelve compounds for in vitro primary screening in the KRas (Kirsten rat sarcoma)-Wnt SL
(Synthetic Lethal) in the basal viability of different colon cancer cell lines. Docking studies of the active THIQs
were also performed in our laboratory, targeting the active sites of KRas and VEGF receptors.

Results:

Compound GM-3-18 was found to possess significant activities for KRas inhibition, with IC50 values
in the range of 0.9 μM to 10.7 μM, for all colon cancer cell lines. Compound GM-3-121 showed potent anti-angiogenesis
activity with IC50 = 1.72 μM. Molecular docking studies showed that the carbonyl oxygen atoms of
GM-3-18 and GM-3-121 showed hydrogen bonding interactions with the hydrogen of - OH groups of THR 74
(A).

Conclusion:

The results indicated that all the compounds showed moderate to high activity for KRas inhibition.
The THIQs bearing the chloro group at the 4-position of the phenyl ring (GM-3-18) exhibited significant
KRas inhibition against all colon cancer cell lines.
Anti-inflammatory, Antioxidant, Lung and Liver Protective Activity of
Galaxaura oblongata as Antagonistic Efficacy against LPS using Hematological
Parameters and Immunohistochemistry as Biomarkers
Authors: Nabil-Adam Asmaa , Shreadah Mohamed Attia
Published: January 2021

Background:

This study aimed to investigate the potential bioactivity and the ameliorative
role of Galaxaura oblongata (G. oblongata) against LPS-induced toxicity using hematological
parameters.

Objective:

The objective of this study is to examine its protective effect using the immunohistochemistry
of the liver and lungs as biomarkers in male BALB/C albino mice.

Materials and Methods:

The current study was carried out using different in-vitro and in-vivo assays,
such as phytochemicals, antioxidants and anti-inflammatory for in-vitro where the hematological
and immunohistochemistry for lung and liver were investigated in vivo.

Results:

No previous studies were performed to investigate the in vivo and in vitro effects of the G.
oblongata extracts as antioxidant and anti-inflammatory due to their rareness compared to other
red algae. LPS treated mice revealed a significant decrease in the total number of WBCs, RBCs,
platelets, and HGB%, MPV, MCV and MCHC compared to the control group. In contrast, the
HCT and MCHC were increased in the induction group, which was treated with LPS compared to
the control group. Furthermore, the immunohistochemistry results of the present study revealed the
protective effect of G. oblongata compared to the induction group. G. oblongata can be used as protective
marine natural products against the toxicity induced by LPS.

Conclusion:

It exhibited a significant ameliorative role against the alterations in the hematological
parameters and immunohistochemistry of the liver and lungs, and reduced as well as coordinated
the acute inflammations caused by TNF.
Carbon and Metallic-based Nanomaterials for Strain Sensors - A Review
Authors: Omprakash Pravan , Kuruveri Udaya B. , Panemangalore Devadas B.
Published: January 2021

Strain gauges are devices whose electrical resistances vary proportionately with the
amount of strain applied on the device. They can be used for real-time applications in the aerospace
sector, as a geotechnical tool in tunnels and bridges, in rail monitoring and health monitoring
sectors. Nanomaterials have been widely used for this application because they can be flexible,
stretchable and have high strength. Several researchers have used numerous carbon-based and metallic
nanostructures to develop functionally graded materials. Among carbon-based materials,
graphene has been widely researched as a viable material for strain sensors due to its superior mechanical
and electrical properties. Also, many metallic nanoparticles have been investigated to design
strain sensors that are highly sensitive to a wide range of strains. In this article, a review of carbon
and metallic nanomaterial-based strain sensors is presented, with emphasis on applications pertaining
to structural health monitoring and wearable devices.
Pemanfaatan Kotoran Ternak sebagai Energi Terbarukan Melalui Pembangunan Biodigester Komunal
Authors:   Universitas Brawijaya, Meidiana Christia , Perdanasari Zhuniart Ayu , Dinanti Dian
Published: January 2021

The potentials of energy from manure waste was calculated in this study aiming to develop biogas utilization in a rural area. The calculation was conducted based on the result from clustering the non-biogas farmer households which cannot afford individual anaerobic digester (AD). Spatial cluster analysis (SCA) and superimposed technique were used to determine the size of the groups and the location of ADs respectively. Value from SCA showed that the village’s settlement pattern is clustered feasible to apply communal AD for rural biogas development. Meanwhile, a superimposed technique using 3 parameters which are land availability, cow ownership, and topography, generates 43 clusters of farmer households that can supply biogas for cooking. The energy production is estimated at 8.96-39.68 m3/day/household, while the energy demand is approximately 0.65-3.48 m3/day/household. The calculation shows that there is remaining biogas that can be distributed to non-biogas farmer households. Using SCA, 75 non-biogas farmer households were identified to be potentially supplied by biogas. The total energy demand for both biogas and non-biogas farmers households is 2,147.34 MJ/day, while the total potential energy generation from all ADs is 24,560.64 MJ/day indicating a low biogas utilization rate which is only 8.7%. The percentage shows that biogas utilization for an energy source in Dusun Dresel can be more developed by enhancing the distribution network or by converting it into electricity to support rural energy security.
Assessing the Effectiveness and Acceptability of a Personalized Mobile Phone App in Improving Adherence to Oral Hygiene Advice in Orthodontic Patients: Protocol for a Feasibility Study and a Randomized Controlled Trial
Authors: Sharif Mohammad Owaise , Newton Jonathon Timothy , Cunningham Susan J
Published: January 2021

Background

Orthodontic treatment is a common health care intervention; treatment duration can be lengthy (2-3 years on average), and adherence to treatment advice is therefore essential for successful outcomes. It has been reported that up to 43% of patients fail to complete treatment, and there are currently no useful predictors of noncompletion. Given that the National Health Service England annual expenditure on primary-care orthodontic treatment is in excess of £200 million (US $267 million), noncompletion of treatment represents a significant inefficient use of public resources.

Improving adherence to treatment is therefore essential. This necessitates behavior change, and interventions that improve adherence and are designed to elicit behavioral change must address an individual’s capability, opportunity, and motivation. Mobile phones are potentially an invaluable tool in this regard, as they are readily available and can be used in a number of ways to address an individual’s capability, opportunity, and motivation.

Objective

This study will assess the effectiveness and acceptability of a personalized mobile phone app in improving adherence to orthodontic treatment advice by way of a randomized controlled trial.

Methods

This study will be conducted in 2 phases at the Eastman Dental Hospital, University College London Hospitals Foundation Trust.
Phase 1 is feasibility testing of the My Braces app. Participants will be asked to complete the user version of the Mobile Application Rating Scale. The app will be amended following analysis of the responses, if appropriate.
Phase 2 is a randomized controlled trial to test the effectiveness and acceptability of the My Braces app.

Results

This study was approved by the London – Bloomsbury Research Ethics Committee on November 5, 2019 (reference 19/LO/1555). No patients have been recruited to date. The anticipated start date for recruitment to phase 1 is October 2020.

Conclusions

Given the availability, affordability, and versatility of mobile phones, it is proposed that they will aid in improving adherence to treatment advice and hence improve treatment completion rates. If effective, the applicability of this methodology to developing behavior change/modification interventions and improving adherence to treatment across health care provides an exciting opportunity.

Trial Registration

ClinicalTrials.gov NCT04184739; https://clinicaltrials.gov/ct2/show/NCT04184739

International Registered Report Identifier (IRRID)

PRR1-10.2196/18021
Digital Health Strategies for Cervical Cancer Control in Low- and Middle-Income Countries: Systematic Review of Current Implementations and Gaps in Research
Authors: Rossman Andrea H , Reid Hadley W , Pieters Michelle M , Mizelle Cecelia , von Isenburg Megan , Ramanujam Nimmi , Huchko Megan J , Vasudevan Lavanya
Published: January 2021

Background

Nearly 90% of deaths due to cervical cancer occur in low- and middle-income countries (LMICs). In recent years, many digital health strategies have been implemented in LMICs to ameliorate patient-, provider-, and health system–level challenges in cervical cancer control. However, there are limited efforts to systematically review the effectiveness and current landscape of digital health strategies for cervical cancer control in LMICs.

Objective

We aim to conduct a systematic review of digital health strategies for cervical cancer control in LMICs to assess their effectiveness, describe the range of strategies used, and summarize challenges in their implementation.

Methods

A systematic search was conducted to identify publications describing digital health strategies for cervical cancer control in LMICs from 5 academic databases and Google Scholar. The review excluded digital strategies associated with improving vaccination coverage against human papillomavirus. Titles and abstracts were screened, and full texts were reviewed for eligibility. A structured data extraction template was used to summarize the information from the included studies. The risk of bias and data reporting guidelines for mobile health were assessed for each study. A meta-analysis of effectiveness was planned along with a narrative review of digital health strategies, implementation challenges, and opportunities for future research.

Results

In the 27 included studies, interventions for cervical cancer control focused on secondary prevention (ie, screening and treatment of precancerous lesions) and digital health strategies to facilitate patient education, digital cervicography, health worker training, and data quality. Most of the included studies were conducted in sub-Saharan Africa, with fewer studies in other LMIC settings in Asia or South America. A low risk of bias was found in 2 studies, and a moderate risk of bias was found in 4 studies, while the remaining 21 studies had a high risk of bias. A meta-analysis of effectiveness was not conducted because of insufficient studies with robust study designs and matched outcomes or interventions.

Conclusions

Current evidence on the effectiveness of digital health strategies for cervical cancer control is limited and, in most cases, is associated with a high risk of bias. Further studies are recommended to expand the investigation of digital health strategies for cervical cancer using robust study designs, explore other LMIC settings with a high burden of cervical cancer (eg, South America), and test a greater diversity of digital strategies.
Digital Health Tools for Managing Noncommunicable Diseases During and After the COVID-19 Pandemic: Perspectives of Patients and Caregivers
Authors: Monaco Alessandro , Palmer Katie , Holm Ravn Faber Nicolaj , Kohler Irene , Silva Mitchell , Vatland Anita , van Griensven Joop , Votta Mariano , Walsh Donna , Clay Vincent , Yazicioglu Mehmet Cuneyt , Ducinskiene Danute , Donde Shaantanu
Published: January 2021

Background

A reduction in the number of face-to-face medical examinations conducted for patients with noncommunicable diseases (NCDs) during the first wave of the COVID-19 pandemic has led to health care professionals quickly adopting different strategies to communicate with and monitor their patients. Such strategies include the increased use of digital health tools. However, patient preferences, privacy concerns, a lack of regulations, overregulation, and insufficient evidence on the efficacy of digital health tools may have hampered the potential positive benefits of using such tools to manage NCDs.

Objective

This viewpoint aims to discuss the views of an advisory board of patient and caregiver association members. Specifically, we aim to present this advisory board’s view on the role of digital health tools in managing patients with NCDs during and after the COVID-19 pandemic, and to identify future directions based on patients’ perspectives.

Methods

As an initiative under the NCD Partnership (PARTners in Ncds Engage foR building Strategies to improve Healthy ageing In Patients) model of Upjohn, a web-based advisory board of patient and caregiver advocates was held on July 28, 2020, to bring together key stakeholders from public and private sectors.

Results

The following key themes emerged: (1) technology developers should understand that the goals of patients may differ from those of health care professionals and other stakeholders; (2) patients, health care professionals, caregivers, and other end users need to be involved in the development of digital health tools at the earliest phase possible, to guarantee usability, efficacy, and adoption; (3) digital health tools must be better tailored to people with complex conditions, such as multimorbidity, older age, and cognitive or sensory impairment; and (4) some patients do not want or are unable to use digital health care tools, so adequate alternatives should always be available.

Conclusions

There was consensus that public-private partnership models, such as the Upjohn NCD Partnership, can be effective models that foster innovation by integrating multiple perspectives (eg, patients’ perspectives) into the design, development, and implementation of digital and nondigital health tools, with the main overall objective of improving the life of patients with NCDs.
NEW VARIATION OF INDONESIAN HUMOR USING LANGUAGE EXPERIENCE
Authors: Yuwana Rawuh Yuda , Santosa Riyadi , Sumarlam Sumarlam
Published: January 2021

Tujuan dari penelitian ini adalah untuk menemukan variasi baru humor Indonesia menggunakan pengalaman bahasa. Penelitian ini adalah penelitian deskriptif-kualitatif. Pengumpulan data menggunakan metode mendengarkan dengan menggunakan teknik dasar sadap - catat. Analisis data dalam penelitian ini menggunakan metode referensi penyamaan dengan menggunakan teknik perbandingan untuk mendukung kodifikasi, reduksi, presentasi, dan interpretasi seperti desain kerja penelitian kualitatif. Sumber data dalam penelitian ini adalah video dan meme. Hasil penelitian menunjukkan bahwa komedian menggunakan 8 strategi dalam bahan humornya, yaitu: (1) mengeksploitasi kebenaran umum yang sudah diketahui orang; (2) mengubah konstituen dengan pengalaman bahasanya; (3) sengaja menempatkan kata ganti yang salah; (4) menyampaikan sesuatu yang tidak lengkap; (5) mengalihkan berbagai bahasa; (6) memberikan respons yang tidak terkait sama sekali; (7) mengeksploitasi celah bahasa untuk mendistorsi maknanya; (8) menyampaikan sesuatu yang tidak wajar, absurd, bahkan terkesan kontroversi.
MENGUNGKAP PENGGUNAAN DIKSI LIRIK LAGU TARLINGDUT KARYA ABDUL ADJIB: KAJIAN STILISTIKA
Authors: Yulistiana Esi , Sumarlam Sumarlam , Satoto Soediro
Published: January 2021

Tujuan penelitian ini adalah untuk mengetahui penggunaan diksi serta fungsinya dalam lirik lagu Tarlingdut karya Abdul Adjib. Penelitian ini menggunakan metode deskriptif kualitatif. Data penelitian berupa frasa, kata, dan kalimat dalam lirik lagu Tarlingdut karya Abdul Adjib. Teknik pengumpulan data yang digunakan dalam penelitian ini menggunakan teknik inventarisasi, baca-simak, dan pencatatan. Analisis data dalam penelitian ini menggunakan model Milles dan Hubberman. Hasil penelitian menunjukkan bahwa empat buah lagu ciptaan Abdul Adjib menggunakan diksi atau pilihan kata yang estetis dalam hal pemilihan kata. Selain itu, dalam lirik lagu Tarlingdut banyak menggunakan diksi yang diambil dari serapan bahasa (1) Jawa khas Cirebon dan (2) bahasa asing yang terdiri dari bahasa Arab, Inggris dan China, serta pemanfaatan sinonim.
Μοῦσαι ὑποφήτορες: a relação entre o narrador e as Musas nos três prólogos das Argonáuticas de Apolônio de Rodes
Authors: Júnior Fernando Rodrigues
Published: January 2021

Este artigo tem como objetivo discutir os três prólogos das Argonáuticas de Apolônio de Rodes, situados no início dos livros 1, 3 e 4, e entender de que maneira a relação oscilante estabelecida entre o poeta e as Musas incita uma reflexão sobre a autoridade narrativa. Ora tendo como fonte do relato a onisciência divina, ora a investigação humana, o poeta se vale da invocação às Musas, entendida como um recurso da poesia épica legado pela tradição, e a dota de um novo sentido através do qual estabelece um diálogo direto com o leitor, guiando o fluxo narrativo e comentando os eventos relatados.
Persona satírica e mudança de tom na obra juvenaliana
Authors: Cordeiro Iana Lima , Leite Leni Ribeiro
Published: January 2021

Neste artigo trazemos um panorama simplificado de duas perspectivas centrais que se apresentam no estudo contemporâneo das Sátiras do poeta romano Juvenal: a aplicação do conceito de persona poética e a interpretação da suposta mudança de tom que existe em sua obra, composta por 16 sátiras. Discutimos em que medida a postura adotada pelos críticos juvenalianos diante dessas questões ditou sua análise dos poemas e apresentamos nosso próprio posicionamento teórico: concordamos com o uso do conceito de persona e defendemos que a obra juvenaliana não apresenta o que se possa definir como mudança de tom, haja vista que consideramos que uma única persona se mantém ao longo de toda a obra.
Epidemiological Factors in Patients with Dermatologic Conditions Referring to Clinic of Traditional Persian Medicine, Shiraz, Southern Iran during 2018: A Cross- Sectional Study
Authors: Parvizi Mohammad Mahdi , Fatehi Nazanin , Jaladat Amir Mohammad , Gholampour Zahra , Shahriarirad Reza , Erfani Amirhossein
Published: January 2021

Introduction: Many patients with chronic diseases often use the
traditional medicine approach in addition to conventional medicine. The
aim of this study was to evaluate the epidemiological factors of
patients with dermatologcal conditions referring to traditional Persian
Medicine (TPM) clinic. Materials and Methods: In this cross-sectional
study, we reviewed all the patients’ medical documents with
dermatological conditions referred to the TPM clinic at Shiraz, Southern
Iran in 2018. Then, the epidemiological factors of the patients were
recorded to a researcher-made data collection form. SPSS software
version 22 was conducted to data analysis. Results: Overall, 631
patients consist of 151 (23.9%) male individuals and 580 (76.1%)
female individuals were enrolled to the study. Most of the patients were
aged between 31 and 40 years, and 347 (55%) patients were married, and
most of them were housewives. The frequency of patients in spring was
higher than other seasons. Furthermore, the most of the patients were
university educated. Acne, eczema and hair loss were the three most
complaints of the patients referring to the traditional medicine clinic.
301(47.7%) patients reported gastrointestinal problems as another
complaint concomitant with their skin problems. Conclusion: It seems
that women with skin problems, including acne, eczema, and hair loss,
were more likely to refer to the TPM clinic. Therefore, development of
TPM clinics in dermatology field as a scientific and academic approach
can be effective in the treatment of patients with dermatological
condition accompanied by traditional medicine.
Calcium-Channel Blockers in Patients with Radial Artery Grafts.
Authors: Moscarelli Marco , Gaudino Mario
Published: January 2021

The use of radial artery (RA) grafts for coronary bypass surgery has
recently gained newer attention since it has been associated with
significant reduction in the risk of midterm cardiac events.
Surprisingly the use on the RA graft as second ‘best’ conduit has been
limited among the surgical community. There may be several explanations
for the little popularity of the RA graft; one of the reasons that could
prevent surgeons to include the RA in the daily surgical armamentarium
it is that patients with RA grafts may require postoperative
calcium-channel blocker (CB) therapy. Due to the thick muscular wall, it
seems possible that the RA would needs CB in order to prevent spasm and
ameliorate patency. CBs are, however, associated with important side
effects; also they have hypotensive effect that can hamper the use of
other therapy such as beta-blocker or angiotensin-converting enzyme
inhibitors. The evidence supporting the use of CB after RA graft (either
in the early phase or as chronic calcium-blocker (CCB)) is weak. A the
post-hoc analysis from the ‘RADIAL’ (Radial Artery Database
International ALliance), showed that in patients with RA, the use of CB
for at least 12 months was associated with better clinical and
angiographic outcomes at mid-term follow-up, but confounders and bias
may be responsible for the reported findings (as healthier patients are
more likely to tolerate CB) . This review aims to summarize current
evidences available on the topic and to serve as benchmark for
evidence-based decision-making for CB prescription after RA grafting.
LEFT ATRIAL APPENDAGE MANAGEMENT: A SURGICAL PERSPECTIVE
Authors: Rosati Fabrizio , Maat Gijs de , Mariani Massimo , Benussi Stefano
Published: January 2021

Atrial fibrillation (AF) is the most common atrial arrhythmia but it is
not a benign disease. AF is an important risk factor for thromboembolic
events, causing significant morbidity and mortality. The left atrial
appendage (LAA) plays an important role in thrombus formation but the
ideal way to manage the LAA is still debated. The increasing popularity
of surgical epicardial ablation and hybrid endo-epicardial ablation
approaches, especially in patients with a more advanced diseased
substrate, has raised the interest in epicardial LAA management.
Minimally invasive treatment options for the LAA offer a unique
opportunity to close the LAA with a clip device. This review highlights
morphologic, electrophysiologic and surgical aspects of the left atrial
appendage with regard to atrial fibrillation surgery, and aims to
illustrate the different surgical management strategies.