bluuebunny/crossref_metadata_2025 huggingface dataset:
Seasonal changes in activity of hypothalamic thyroid hormone system in different winter phenotypes of Djungarian hamster (Phodopus sungorus)
Authors: Przybylska-Piech Anna S. , Diedrich Victoria , Herwig Annika
Published: October 2024

Although the Djungarian hamster (Phodopus sungorus) is a seasonality model, it presents substantial variability in winter acclimation. In response to short photoperiod, some individuals express a suite of winter traits such as low body mass, regressed gonads, white fur, and daily torpor, while others develop only some adjustments or maintain a summer phenotype. Despite comprehensive research, the mechanisms underlying polymorphism of winter phenotype are still unknown. We compared key elements of the hypothalamic thyroid hormone system, as well as the tanycyte architecture in hamsters of both sexes. Individuals presented different responses to short photoperiod characterized either as phenotypes (non-responder, partial-responder and full-responder) or photoresponsive index. We measured the expression of genes coding iodothyronine deiodinase 2 and 3, monocarboxylate transporter 8, thyrotropin-releasing hormone, and somatostatin in 40 individuals and counted the number of immunolabeled tanycyte processes in standardized regions of interest around the third ventricle in 30 individuals. Animals acclimated to short photoperiod presented a downregulation of diodinase 2 and somatostatin and an upregulation of deiodinase 3, as well as a decreased number of tanycyte processes, compared to long photoperiod-exposed individuals. Although phenotypes did not differ in gene expression, the higher the photoresponsive index, the lower was the deiodinase 2 expression and the higher the deiodinase 3 expression. Partial-responders and full-responders had less tanycyte processes than non-responders, and the number of tanycyte processes correlated with the photoresponsive index. Sexes differed neither in their seasonal response, nor hypothalamic gene expression, but females had more tanycyte processes. Our results are in accordance with studies emphasizing the pivotal role of thyroid hormones in seasonal response. We suggest that the whole spectrum of winter phenotypes exists within the population of Djungarian hamsters and that it is reflected also at the level of neuroendocrine regulation. However, the neuroendocrine underpinnings of winter phenotype polymorphism require further investigation.
Evaluation of the performance and stability of early maturing orange-fleshed sweetpotato genotypes in selected areas in Ethiopia
Authors: Mekonnen Bililign , Gurmu Fekadu
Published: October 2024

Orange-fleshed sweetpotato varieties that mature and harvest sooner play an important role in addressing food and nutrition demands in areas where irregular rainfall makes sustainable production challenging. A national variety trial was conducted in 2021 and 2022 during the main cropping season using ten OFSP genotypes in three locations in Sidama, South, and Oromia regions of Ethiopia, namely Hawassa, Arbaminch, and Koka, respectively. The objective of this study was to develop and select early-maturing and high-yielding OFSP genotypes for short-term harvesting (3–4 months). The field trial was conducted in a randomized complete block design with three replications. Data were collected on root yield and yield-related traits, sweetpotato virus disease reactions (SPVD), root dry matter (DMC), and beta-carotene contents (BCC) and were subjected to analysis of variance. A genotype plus genotype by environment interaction (GGE) bi-plot was also used to determine genotype stability. The results showed the presence of highly significant (p<0.001) differences among locations and genotypes, reflecting the existence of differential responses among genotypes in varied locations. Based on combined analysis, G3 (13NC9350A-9-3) outperformed the other genotypes for most of the traits considered, except for DMC, i.e., which has an equivalent to the check variety (Alamura) and showed a yield advantage of 41.4% over it. The GGE biplot also revealed that the G3 was the vertex genotype with the consistent performance in all environments. It had a low score of 1.39 on the 1–9 scoring scale, indicating that it falls within the resistant range, with adequate levels of BCC (5.5 mg/100 g) and DMC (30.0%). Furthermore, G3 is an early-maturing variety, which allows other crops to be grown in double and relay cropping systems. Therefore, based on its outstanding performance, G3 is recommended for verification and release for cultivation in mid- to low-land areas in Ethiopia.
Recovery and partial isolation of ⍺-mangostin from mangosteen pericarpsvia sequential extraction and precipitation
Authors: Han Moh Moh , Tangpromphan Preuk , Kaewchada Amaraporn , Jaree Attasak
Published: October 2024

This study introduced an innovative sequential extraction methodology designed for the efficient recovery of alpha-mangostin (⍺-M) from mangosteen pericarps. Alpha-mangostin, renowned for its pharmacological properties including anti-inflammatory, anti-cancer, and anti-bacterial effects, has garnered significant attention across diverse industries. The proposed method of sequential extraction achieved 73% recovery and a yield of 46.75 mg/g based on the weight/weight percentage of the mass of ⍺-M extracted from the sequence and the mass of raw material. Furthermore, the purity of the dried product was 67.9%. The sequence solvent extraction system, comprising water, hexane, and acetonitrile, plays a pivotal role in enhancing the efficacy of the extraction process. Notably, this methodology offers a cost-effective alternative to conventional extraction methods. It reduces the need for complex equipment and processes, positioning it as a resource-efficient extraction technique in comparison to existing methodologies. This novel sequential extraction method presents a promising avenue for the economical and sustainable recovery of alpha-mangostin (⍺-M) from pericarps.
Development and content validation of the Childhood Early Oral Aging Syndrome (CEOAS) index for the deciduous dentition: Research protocol
Authors: Honório Mandetta Amanda Rafaelly , Gimenez Thais , Sobral Ana Paula Taboada , Spinola Sandra Gouveia , Gonçalves Marcela Leticia Leal , Soares Paulo Vinícius , Santos Elaine Marcilio , Imparato José Carlos Pettorossi , Horliana Anna Carolina Ratto Tempestini , Mesquita-Ferrari Raquel Agnelli , Motta Lara Jansiski , Fernandes Kristianne Porta Santos , Kalil Bussadori Sandra
Published: October 2024

Premature, non-physiological tooth wear in childhood has numerous repercussions for oral health. This is a growing problem with multifactorial causes and associated with the current lifestyle. The introduction of new concepts and indices is crucial for enhancing the understanding and management of dental conditions. In this context, we present the Childhood Early Oral Aging Syndrome (CEOAS) and the associated index, which aim to assess early enamel wear in the primary dentition. Rather than focusing solely on isolated etiologies, the index proposes a comprehensive evaluation of signs and symptoms, considering various factors that contribute to the premature and non-physiological loss of dental structure, including wear of both intact and hypomineralized enamel. Indices that evaluate the main factors of early oral aging in childhood and their interactions are fundamental for understanding the condition and developing effective control and treatment strategies, particularly given that there is currently no global index encompassing this information. The aim of the present study was the development and determination of content validity of the Childhood Early Oral Aging Syndrome (CEOAS) index for the primary dentition as a diagnostic and epidemiological survey tool.

Trial registration: ClinicalTrials.gov ID: NCT06378385.
Plasma and breast milk adipokines in women across the first year postpartum and their association with maternal depressive symptoms and infant neurodevelopment: Protocol for the APPLE prospective cohort study
Authors: Rebelo Fernanda , de Moura Cintia Oliveira , Ranquine Layla Galvão , Teixeira Thaisa de Mattos , Ribas Mariana Terra Nunes , Vitorino Raquel Santiago , de Abranches Andrea Dunshee , Costa Roozemeria Pereira , de Britto José Augusto Alves , Marano Daniele , Soares Fernanda Valente Mendes , Junqueira-Marinho Maria de Fátima , de Sousa Carlos Augusto Moreira , Franco-Sena Ana Beatriz , Nardi Antônio Egídio , El-Bacha Tatiana , Moreira Maria Elisabeth Lopes
Published: October 2024

Introduction

Adiponectin and leptin play important roles in the central nervous system. During the postpartum period, there is a need for a better understanding of the relationship between these cytokines and the neurological development of the infant, as well as their influence on preventing maternal depressive symptoms.

Objectives

To assess the correlation between adiponectin and leptin in maternal plasma and breast milk and their association with: infant neurodevelopment at 6 and 12 months of age; and maternal mental health over the first year postpartum.

Methods

Prospective cohort study with four follow-up. Mothers and their newborns are recruited within the first 15 days postpartum (baseline). Follow-up visits occur at 2, 6, and 12 months postpartum. Visits include blood and breast milk collection, application of the Edinburgh Postnatal Depression Scale and Beck Depression Inventory to assess maternal mental health, application of the Bayley-III scale for infant developmental assessment, maternal and infant anthropometry and body composition, evaluation of reproductive history, mother-infant bonding, breastfeeding, consumption of ultra-processed foods, sleep quality, and socio-economic and demographic data.

Results

The research received funds in August 2022, and participant recruitment began in September 2022. The sample size will consist of 95 mother-child pairs. As of September 2023, 68 participants have been recruited.

Conclusion

The project will provide insights into the association between adiponectin and leptin with postpartum depression and infant neurodevelopment, ultimately promoting improved care and quality of life for these groups. Additionally, it will provide data on the type of delivery, infant physical growth, maternal and infant body composition changes, sleep quality, consumption of ultra-processed foods, and maternal metabolic health, including vitamin D metabolites, oxidized polyunsaturated fatty acid metabolites, phospholipid species and triacylglycerols, which are of significant relevance to public health and, when interconnected, may yield important results and contribute to the existing literature.

Trial registration

Name of the registry: Brazilian Clinical Trials Registry (ReBec).

Registration number: RBR-9hcby8c.
Climate policy uncertainty and its impact on real estate market dynamics: A sectoral and regional analysis
Authors: Cho Chulyoung , Yang Jinseok , Jang Beakcheol
Published: October 2024

This study explores the impact of Climate Policy Uncertainty (CPU) on real estate market volatility, utilizing the CPU index to assess how climate policy affects various real estate segments. It highlights the significant impact of CPU on sectors with high energy demand and emissions, such as industrial and residential. A multi-horizon analysis reveals the long-term sensitivity of CPU’s influence, with significant sensitivity noted in coastal regions prone to climate risks. The findings provide crucial insights for investors and policymakers, emphasizing the importance of integrating CPU considerations into strategic decision-making for real estate investment.
The mechanism of NF-κB-TERT feedback regulation of granulosa cell apoptosis in PCOS rats
Authors: Xue Haoxuan , Hu Zecheng , Liu Shun , Zhang Shun , Yang Wenqin , Li Jiasi , Yan Chulin , Zhang Jiaming , Zhang Jing , Lei Xiaocan
Published: October 2024

Patients with Polycystic ovary syndrome (PCOS) have chronic low-grade ovarian inflammation. Inflammation can cause telomere dysfunction, and telomere and telomerase complex are also involved in regulating inflammation. However, the specific mechanisms of inflammatory signaling feedback and telomere-telomerase mutual regulation remain to be discovered. This study elucidates the role of Nuclear factor kappa-B (NF-κB)-Telomerase reverse transcriptase (TERT) feedback in PCOS granulosa cell apoptosis. Using letrozole and a high-fat diet, a PCOS rat model was established, along with a Lipopolysaccharide (LPS) -treated KGN cell inflammation model was established. NF-κB and TERT inhibitors (BAY 11–7082 and BIBR1532) were then administered to LPS-induced KGN cells. PCOS rats displayed disrupted estrous cycles, increased weight, elevated serum testosterone, cystic follicles, granulosa cell layer thinning, and reduced corpora lutea count (P are all less than 0.05). In PCOS rat ovaries, NF-κB, Interleukin-6 (IL-6), Tumor Necrosis Factor α (TNF-α), TERT, Bax, and Caspase-3 exhibited notable upregulation, while Bcl-2 decreased, with telomere elongation (P are all less than 0.05). There were significant correlations among NF-κB-related inflammatory factors, TERT and apoptotic factors, and they were positively correlated with Bax and Caspase-3, and negatively correlated with Bcl-2 (P are all less than 0.05). LPS-treated KGN cells demonstrated increased expression of inflammatory and pro-apoptotic factors, later restored post-treatment with NF-κB and TERT inhibitors (P are all less than 0.05). In conclusion, TERT may induce granulosa cell apoptosis by participating in the regulation of the NF-κB signaling pathway, thereby mediating the chronic inflammatory response of PCOS through downstream inflammatory factors IL-6 and TNF-α.
Examining the burden and relationship between stunting and wasting among Timor-Leste under five rural children
Authors: Bahwere Paluku , Judge Debra S. , Spencer Phoebe , Chiwile Faraja , Mutunga Mueni
Published: October 2024

Globally and in Timor-Leste, wasting and stunting remain major public health problems among ‘under five years children, but the interrelationship between the two has been poorly investigated. A better understanding of this interrelationship is a prerequisite to improving wasting and stunting programming. In our study, we assessed the influence of age on the prevalence of wasting and stunting, the overlap between the two conditions, and the effect of wasting parameters on linear growth catch-up using the data of 401 children recruited at 0 to 54 months of age [median (IQR) of 17 (7–32) months] with repeated anthropometric assessments [median (IQR) follow-up time was 25 (16–39) months]. At recruitment, prevalences of stunting, wasting and concurrence of the two conditions were 54.6%, 9.5% and 4.6%, respectively. These prevalences were already high and above the thresholds for public health importance among children below months of age and remained high throughouttheir childhood. Over the follow-up period, the change (95%CI) in Height-for-Age Z-score (HAZ) was -0.01 (-0.13; 0.11) (p = 0.850), and that of the Height-for-Age Difference (HAD) was -3.74 (-4.28; -3.21) cm (p<0.001). Stunting reversal was observed in 25.6% of those stunted at recruitment, while a positive change in HAD was observed in only 19.6% of assessed children. Path analysis by structural equation modelling showed no significant direct effect of WHZ at recruitment on the likelihood of positive change in HAD, with its influence being fully mediated by its change over the follow-up period. This change had an inverse relationship with the occurrence of a positive change in HAD. On the contrary, Mid-Upper Arm Circumference at recruitment had a significant positive direct effect on the likelihood of a positive HAD change. These results show that interventions to combat wasting and stunting need to be integrated.
Prescription of antibiotics for urinary tract infections in outpatient care in Bavaria: An analysis of routine data
Authors: Hanslmeier Thomas , Alsaiad Sahera , Hueber Susann , Kurotschka Peter K. , Gerlach Roman , Gágyor Ildikó , Kaußner Yvonne
Published: October 2024

Background

Patients with urinary tract infection (UTI) in German outpatient care are usually treated by general practitioners (GPs), as well as by other specialties. To prevent antibiotic resistances and side effects, German guidelines recommend fosfomycin, nitrofurantoin, pivmecillinam and nitroxoline as first-line treatments, and advice against broad-spectrum antibiotics such as fluoroquinolones and cephalosporins. However, data from the European Centre for Disease Prevention and Control indicates a significant proportion of second-line antibiotics in German outpatient care. Our aim was to analyze whether antibiotic prescription has changed over time in accordance with guidelines. In addition, we aimed to investigate whether specialties prescribe different antibiotics for UTIs and whether prescription varies according to patient age and sex. For patients receiving more than one antibiotic, we wanted to determine whether subsequent prescriptions show a change in substances and specialties involved.

Methods

This retrospective study involved routine data (2013 to 2019) provided by the Bavarian Association of Statutory Health Insurance Physicians. Data on diagnoses and prescriptions were transmitted from outpatient care physicians on a quarterly basis. UTI patients ≥12 years were included.

Results

We analyzed 1.7 million UTI prescription cases. In females, shares of fluoroquinolones decreased sharply over time, while shares of first-line substances fosfomycin and pivmecillinam increased. Gynecologists showed the highest shares of first-line substances compared to GPs and urologists. Fluoroquinolone shares decreased in all three specialty groups. In females, older patients showed lower shares of first-line substances than younger patients. If a second or third antibiotic was prescribed, fosfomycin shares decreased, while shares of nitrofurantoin, nitroxoline and cephalosporins increased.

Conclusions

Our findings show a trend towards a more guideline-adherent prescribing in the treatment of UTI, with a significant increase of shares of fosfomycin and pivmecillinam, especially in women, and a sharp decrease of shares of fluoroquinolones.
Növények a mikroszkóp alatt
Authors: Bakacsy László , Szepesi Ágnes
Published: October 2024

A 100 éves múltra visszatekintő Szegedi Tudományegyetem Növénybiológiai Tanszékén a növényanatómia és növényszervezettan kiemelt szerepet töltött és tölt be a mai napig nemcsak az oktatásban, de a kutatásban is. Az elmúlt 100 év során értékes mikroszkópos metszetgyűjtemény jött létre, amely felbecsülhetetlen értéket képvisel napjaink biológus hallgatói számára is. Az oktatásban eltöltött tapasztalataink alapján szükség van a növénybiológiai ismeretek tudományos ismeretterjesztő formában történő megosztására, figyelembe véve az Európai Unió célkitűzéseit, az Open Science és Open Access törekvéseknek megfelelően. Napjaink digitális technológiai megoldásait is felhasználva a Mecenatura pályázat keretében célul tűztük ki, hogy ezt az értékes gyűjteményt, amelyben még 1954-ből származó metszet is található, mindenki számára szabadon hozzáférhetővé tesszük. A könyvet az érdeklődők számára a legjelentősebb és leglátványosabb metszetek felhasználásával készítettük, olyan növényekből, amelyek közismertek az olvasók számára, de belső felépítésüket még nem ismerhetik. A könyv ábrái hallgatók bevonásával készültek, és folyamatban van egy online elérhető adatbázis a tanszéki gyűjtemény további metszeteinek bemutatásához. Úgy gondoljuk, hogy a kiadvány nagyban segítheti az olvasó növények iránti érdeklődésének felkeltését hozzájárulva ahhoz, hogy az ember a természetet megismerve, a biodiverzitást előtérbe helyezve fenntartható módon alakítsa ki életkörülményeit. Reméljük, hogy a jövőben ez a kiadvány sokakban felkelti az érdeklődést a növények iránt.
Quién mató a Anna Cook? A conversational review
Authors: de Beauvoir Charlotte , Uprimny Tomás
Published: October 2024

The Chilean podcast ¿Quién mató a Anna Cook? (Who killed Anna Cook?) tells the story of Anna Cook — a DJ found dead in her home in Santiago in August of 2017 — and those suspected of murdering her. Her death had a significant impact on Chilean society, and her name became a slogan during a series of massive protests that swept the country beginning in 2019. Within a month of the podcast’s release, it reached more than 350,000 reproductions. In this review, audio producers and journalists Tomás Uprimny and Charlotte de Beauvoir analyse the podcast in conversation and reflect on its storytelling, sound design and unusual use of fictional hosts.
How Digital Power Shapes the Rule of Law: The Logic and Mission of Digital Rule of Law
Authors: Sun Xiaoxia , Xiao Yang
Published: October 2024

The rise of digital technologies has led to the emergence of digital private and public powers, which pose significant societal risks, challenge human rights, and reshape the rule of law. Digital power, as a new form of power, possesses inherent legal characteristics from both factual and normative perspectives. Therefore, it is crucial to integrate digital power into legal studies and frameworks. While subject to legal regulation, digital power also has the potential to address the limitations of human law, enhance human rights, and strengthen the rule of law. It is therefore argued in this study for the necessity of expanding legal studies from a focus on algorithm research to the broader study of digital power. This study also highlights the unique mission of the digital rule of law, to harness digital power in shaping a future legal system that empowers and promotes societal well-being.
Optimization of the process parameter of lean-grade self-reducing pellets by surface response modelling
Authors: Barman Ajitesh , Khan Santosh , Dey Rajib , Biswas Chanchal
Published: October 2024

In the Indian context, the production of steel is increasing day by day. The huge crude steel output requires enormous amounts of raw materials from the mining industry. The availability of high-grade steel-making raw materials has decreased worldwide. There are huge challenges for the metallurgist in developing a suitable process in the steel industry, which is essential due to the possible scarcity of high-grade raw materials in the future. In this present study, an appropriate process for lean-grade iron ore and non-coking coals, along with the binders, is used as self-reducing composite pellets for iron making. These composite pellets are made in different combinations, including particle sizes, different non-coking coals, and binders. Initially, the mechanical properties of composite pellets are evaluated through the shatter and abrasion index. Then, cold-bonded self-reducing pellets are directly reduced in a standard tube furnace at varying temperatures and times. The reduced samples are further characterized using X-ray diffraction, scanning electron microscopy, and chemical analysis methods. Finally, Box–Behnken Design statistical modelling based on the extent of reduction (EOR) is successfully utilized for optimizing the process parameters.
Optical sectioning in fluorescence microscopies is essential for volumetric measurements
Authors: Stelzer Ernst H. K.
Published: October 2024

Optical sectioning in fluorescence microscopy is a cornerstone technique that allows scientists to visualize three-dimensional architectures of specimens with high resolution. The optical sectioning capability has become crucial for advancing our understanding in various technical and scientific fields such as cellular and developmental biology. Several microscopy techniques stand out due to their ability to perform true optical sectioning through distinct optical arrangements. The paper explains formally, how optical sectioning is harnessed in confocal, two-photon, confocal theta, and light sheet-based fluorescence microscopy. The latter’s implementation of optical sectioning fosters detailed studies with morphologically intact fertile specimens as a function of long time periods.
Production of (B4C+FeTi) reinforced and Fe based composites by mechanical alloying
Authors: Yilmaz Serdar Osman , Teker Tanju , Milli Ahmet
Published: October 2024

In this study, the microstructure and mechanical performance of Fe-based composites reinforced by FeTi+B4C at various ratios were determined. The study was based on the production of Fe based nano carbide and boride (B4C, Fe2B, Fe7C3, TiB2) reinforced composites. Mechanical alloying technique was chosen to reduce the reinforcement material to nano size and distribute it homogeneously. Sintering temperature was used as 1,100 °C and sintering time as 2 h. The reionforcement “FeTi+B4C” ratio was raised up to 15 wt.%. The microstructure and phases of the composite samples were descrived by scanning electron microscopy, energy dispersive spectroscopy, X-RD analysis and hardness. The concentration of voids and the stiffness changes of the samples were determined. The size of TiC and TiB2 particles reduced significantly with the rise in B4C ratio. Since the hardness of TiB2 was less than that of the B4C matrix, the hardness reduced with increasing TiB2 ratio.
Integrated Network Ethnopharmacology, Molecular Docking, and ADMET Analysis Strategy for Exploring the Anti-Breast Cancer Activity of Ayurvedic Botanicals Targeting the Progesterone Receptor
Authors: Mokashi Asma , Bhatia Neela M.
Published: October 2024

Background: In women, breast cancer is currently among the most common cancers and the second major cause of cancer-related mortality. One therapeutic target for breast cancer is the progesterone receptor (PR), which can be inhibited by specific PR modulators.

Methods: Current anti-cancer medications have notorious adverse effects. Consequently, an urgent need exists to identify less hazardous, more effective medicines with few to no adverse effects. One strategy uses ancient herbal remedies to create medications derived from nature. Herein, we used data from the Dr. Duke, IMPPAT, PubChem, Binding DB, UniProt, and DisGeNET databases to construct a network in Cytoscape 3.10.0. Through a polypharmacology approach, bioactives with similarity indices greater than 0.6 were screened and docked with the PR. The top ten ligands with good docking scores were further subjected to interaction analysis in AutoDock v.4.2 software. We additionally analyzed the ADMET properties of the phytochemicals.

Results: Procurcumenol and alpha-turmerone exhibited superior interactions with PR, with binding affinities of −7.85 kcal/mol. All compounds met Lipinski’s rule of five and were effective ligands for the PR according to ADMET data analysis. Our findings suggest that procurcumenol and alpha-turmerone may serve as potential anti-breast cancer agents; specifically targeting the PR in breast cancer cells.

Conclusion: Understanding of anti-breast cancer activity can be facilitated through experimental validation of network analysis and molecular docking findings.
Spatiotemporal Mapping of Auditory Onsets during Speech Production
Authors: Kurteff Garret Lynn , Field Alyssa M. , Asghar Saman , Tyler-Kabara Elizabeth C. , Clarke Dave , Weiner Howard L. , Anderson Anne E. , Watrous Andrew J. , Buchanan Robert J. , Modur Pradeep N. , Hamilton Liberty S.
Published: October 2024

The human auditory cortex is organized according to the timing and spectral characteristics of speech sounds during speech perception. During listening, the posterior superior temporal gyrus is organized according to onset responses, which segment acoustic boundaries in speech, and sustained responses, which further process phonological content. When we speak, the auditory system is actively processing the sound of our own voice to detect and correct speech errors in real time. This manifests in neural recordings as suppression of auditory responses during speech production compared with perception, but whether this differentially affects the onset and sustained temporal profiles is not known. Here, we investigated this question using intracranial EEG recorded from seventeen pediatric, adolescent, and adult patients with medication-resistant epilepsy while they performed a reading/listening task. We identified onset and sustained responses to speech in the bilateral auditory cortex and observed a selective suppression of onset responses during speech production. We conclude that onset responses provide a temporal landmark during speech perception that is redundant with forward prediction during speech production and are therefore suppressed. Phonological feature tuning in these “onset suppression” electrodes remained stable between perception and production. Notably, auditory onset responses and phonological feature tuning were present in the posterior insula during both speech perception and production, suggesting an anatomically and functionally separate auditory processing zone that we believe to be involved in multisensory integration during speech perception and feedback control.
Introducción a la historia: Una mirada sobre el pasado, la historiografía y la crítica poscolonial
Authors: Izquierdo Martín Jesús
Published: October 2024

Este no es un manual al uso: es más bien un inductor para hacer explosionar el pensamiento reflexivo, no solo hacia la crítica de las relaciones ‘normalizadas’ de Oriente y Occidente, sino también hacia el análisis de las construcciones históricas de sus distintos pasados
El derecho y sus reveses: Hacia una historia jurídica contemporánea del siglo XX
Authors: Stolleis Michael
Published: October 2024

“El jurista cegado para la historia resulta peligroso”; peligroso en la medida en que, por regla general, un jurista sin conocimientos de historia tiende a buscar el derecho vigente solo en el Boletín Oficial. Y sin conocimiento de la historia apenas resulta posible juzgar críticamente ciertos fenómenos.
Renewable resources derived cellulose nanocrystal stimuli responsive Pickering emulsions
Authors: Zhang Jinlong , Wu Qinglin , Li Weiguo , Negulescu Ioan
Published: October 2024

As an environmentally friendly and sustainable nanoparticle stabilizer of Pickering emulsions, cellulose nanocrystal (CNC) has attracted attention because of its sustainable and biodegradable characteristics. Despite its distinct amphiphilic character as an ideal nanomaterial to replace traditionally non-sustainable surfactant emulsifiers, its long-term stability and lack of responses from external stimuli [e.g., pH, temperature, and carbon dioxide (CO2)] are the critical issues to be addressed. The solutions for all of these questions in terms of CNCs and its responsive Pickering emulsions are systemically discussed in this review.
Синтез та in silico дослідження 4,4-дизаміщених (E)-2-[(4-сульфамоїлфеніл)гідразиніліден] тетрагідротіофен-1,1,3-триоксидів
Authors: Коломієць A.Ю. , Балабушко M.O. , Мілохов Д.С. , Полюдов А.O. , Воловенко Ю.М. , Добриднєв О.В.
Published: October 2024

Розроблено ефективний метод синтезу 4,4-дизаміщених (E)-2-[(4-сульфамоїлфеніл)гідразиніліден] тетрагідротіофен-1,1,3-триоксидів, у тому числі тих, що мають спіроциклічні замісники. Цей клас сполук розглядається як сульфаніламідні препарати нового покоління з широким спектром біологічної активності. Дослідження in silico показали, що синтезовані сполуки відповідають вимогам лікоподібності, мають перспективний ADMET профіль і потенційну протибактеріальну та протиракову активності.
Регуляризація частково цілочислової задачі векторної оптимізації з квадратичними функціями критеріїв
Authors: Лебєдєва Т.Т. , Семенова Н.В. , Сергієнко Т.І.
Published: October 2024

Представлено нові результати, пов’язані з регуляризацією частково цілочислових задач оптимізації за Парето за умов можливих збурень вхідних даних векторного критерію, який складається з квадратичних функцій. Розроблена процедура регуляризації ґрунтується на використанні властивості стійкості відносно збурень коефіцієнтів критеріїв векторної задачі оптимізацїі за Слейтером.
Дослідження впливу параметрів тріщиностійкості на критичне навантаження зразка з тріщиною нормального відриву при триточковому згині в рамках когезійної моделі
Authors: Богданов В.Л. , Селіванов Д.М.
Published: October 2024

В статті для аналізу процесу руйнування зразка з крайовою тріщиною I типу за умов триточкового згину використано когезійну модель зони передруйнування біля вершини тріщини. При цьому застосовано внутрішню модель з трапецоїдальним законом зчеплення–відриву в когезійній зоні. У скінченно-елементному дослідженні контактна взаємодія врахована штрафним методом. Проаналізовано вплив на критичне навантаження параметрів когезійної зони, таких як когезійна міцність і параметри форми. Продемонстровано як зі збільшенням когезійної міцності прогноз щодо критичного навантаження, отриманий в рамках нелінійної механіки руйнування, наближається до прогнозу, отриманого в рамках лінійної механіки руйнування.
ФІНАНСОВА БЕЗПЕКА В УМОВАХ ВІЙНИ І В ПЕРІОД ПОВОЄННОГО ВІДНОВЛЕННЯ УКРАЇНИ
Authors: ЛУПЕНКО Юрій , РАДІОНОВ Юрій
Published: October 2024

Проаналізовано дефініції терміна «фінансова безпека». Дано власне узагальнене визначення терміна «фінансова безпека держави». Розкрито проблеми наповнення бюджету в умовах війни. Проаналізовано 13-річну динаміку формування доходів і видатків державного бюджету України. Доведено значне зростання дефіциту державного бюджету України з початком широкомасштабної війни порівняно з довоєнним періодом. Проаналізовано показники державного і гарантованого державою боргу України за період 2021–2023 рр., досліджено положення Середньострокової стратегії управління державним боргом на 2024–2026 роки, яка враховує нову економічну реальність, що настала з початком війни.
Зазначено, що фінансова безпека досягається завдяки стабілізації фінансової системи, удосконалення її механізмів, що дозволить адекватно реагувати на виклики і загрози як у мирний час, так і в умовах воєнного стану. Напрацьовано шляхи зміцнення фінансової безпеки держави під час війни і в період повоєнного відновлення України. Зазначено, що уряд докладає певних зусиль для забезпечення безперебійного функціонування фінансової системи, що є основою стабільності фінансової безпеки держави. Акцентовано на важливості забезпечення соціальної та економічної безпеки. Наголошено на посиленні протекціоністської ролі держави із застосуванням кейнсіанської моделі в регулюванні економіки, зокрема, шляхом широкого застосування методів, інструментів фіскального стимулювання ділової активності, розвитку підприємництва, регулювання зайнятості населення, інвестицій і заощаджень, а також стимулювання впровадження інновацій. Залучення цих важелів дозволить відновити економічний потенціал держави, втрачений під час війни, збільшити фінансовий простір, забезпечити відновлення й стійку динаміку розвитку України в період відбудови, сприятиме захисту внутрішнього ринку від зовнішніх загроз і викликів не лише війни, а й екзистенційних ризиків глобалізованого світу, зміцнить фінансову безпеку країни нині й у майбутньому.
THE EFFECT OF GREEN MARKETING MOTIVATION FACTORS ON CONSUMERS' PURCHASE INTENTION THROUGH THE MEDIATING ROLE OF GREEN BRAND TRUST TO COUNTER GREENWASHING
Authors: BOURICHE Ahmed , HAMLI Abdelkader , ALI Naeem , BENAISSA Benamar
Published: October 2024

This study examines the influence of green marketing motivational factors on Algerian consumers' purchase intentions, specifically focusing on the mediating role of green brand trust in mitigating greenwashing's impact. The research, conducted in Maghnia, a city on the western border of Algeria, surveyed 262 consumers using a structured questionnaire. Analyzing the data using Partial Least Squares Structural Equation Modeling (PLS-SEM), the study reveals that green brand trust acts as a critical mediator between green marketing factors and purchase intentions. It finds that positive reception of green advertising and a strong green brand image significantly enhance green brand trust, which in turn, strongly influences consumers' intentions to purchase green products.
Further analysis demonstrates that while non-deception and transparency do not directly impact green brand trust, they act as important moderators, enhancing the link between green advertising reception and trust. Notably, the study highlights the pervasive issue of greenwashing in Algeria, demonstrating how misleading environmental claims undermine consumer trust and purchase intentions. The study underscores the need for companies to prioritize genuine environmental efforts and ethical marketing practices to build lasting consumer relationships. Furthermore, the research emphasizes the importance of promoting environmental awareness among consumers through education programs and awareness campaigns, as well as strengthening environmental legislation to prevent deceptive practices. By understanding the complex relationship between green marketing factors, green brand trust, and purchase intentions, this study offers valuable insights for developing sustainable consumption patterns in developing economies while mitigating the negative effects of greenwashing.
DYNAMICAL CONDITIONS OF THE SPATIAL EXTREMES FORMATION IN OZONE LAYER OVER THE TERRITORY OF UKRAINE
Authors:   Ukrainian Hydrometeorological Institute of the State Emergency Service of Ukraine and the National Academy of Sciences of Ukraine, Kyiv, Umanets Antonina , Krainyk Sofiia ,   Ukrainian Hydrometeorological Institute of the State Emergency Service of Ukraine and the National Academy of Sciences of Ukraine, Kyiv, Savenets Mykhailo ,   Ukrainian Hydrometeorological Institute of the State Emergency Service of Ukraine and the National Academy of Sciences of Ukraine, Kyiv
Published: October 2024

The paper examines the conditions for the formation of spatial extremes in total ozone content (TOC) over the territory of Ukraine caused by dynamic factors. The study used satellite observations of TOC and meteorological parameters (u,v components of wind and geopotential height) from the ERA5 reanalysis in the Northern Hemisphere. We describe the processes of air advection with significant TOC deviations and implement its classification into the main types. Seventy cases of spatial extremes were identified, 86% of which were observed under air advection with a western component. The intense westerly flow in the lower stratosphere is responsible for both the advection of air with high TOC (total ozone content) and its local formation. Under a well-developed polar vortex, most ozone extremes are transported by the main flow and reach the territory of Ukraine from the west and northwest, forming significant positive deviations. In this case, the polar vortex itself must be displaced into the Eastern Hemisphere for Ukraine to be closer to its outer boundary. When the integrity of the polar vortex is disrupted, it takes on a wavelike structure, leading to greater variability in the processes forming ozone extremes over Ukraine, including TOC advection from the north and local formation. With the breakdown of the polar vortex and the onset of a rapid TOC decrease in late March to April, the likelihood of positive ozone deviations from the north increases, though their recurrence does not exceed 7% of the total number of extremes. Significant negative TOC deviations spread over Ukraine during the period of seasonal minima under two conditions: advection from the northwest when the stratospheric polar vortex is absent (until November), and advection from the west in the early stages of vortex formation (in December). The established and described dynamic conditions for the formation of ozone layer extremes are important for extending the lead time in forecasting ozone anomalies over Ukraine.
Improving Family-Centered Rounds With a Nursing Checklist in the Electronic Health Care Record
Authors: Madduri Gayatri Boddupalli , Nichols Tristan , Gunturkun Fatma , Johnson Denise , Lum Anne , Shaner Mason Agatep , Weng Yingjie , Srinivas Nivedita , Dos Santos Lyn
Published: October 2024

OBJECTIVE

Family-centered rounds (FCR) is the standard for pediatric communication, but community pediatric hospital medicine services may face barriers in implementation, including offering FCR to families with a language preference other than English (LOE) versus those with an English preference (EP). The goal of our quality improvement project was to increase FCR from 33% to 80% over 1 year.

METHODS

Interventions included an FCR checklist integrated into the electronic healthcare record (EHR-FCR checklist), staff education, visual prompts, and interpreters. Our primary outcome measure was weekly % FCR. Our main process measure was weekly % nursing documentation. To address language inclusion, we compared FCR encounters for families with LOE versus EP. The use of the checklist without interventions was assessed during the sustain period. Control charts were used to analyze measures. Fisher’s exact test was used to compare FCR for families with LOE versus EP.

RESULTS

FCR increased to 81% during the intervention period and then decreased to 73% during the sustain period. Nursing documentation increased to 93% with the EHR-FCR checklist implemented as a flowsheet. There was no statistical difference in the proportion of families with LOE versus EP who participated in FCR (84% versus 81%, P = .38) during the intervention period; a statistically higher proportion of families with LOE participated in FCR during the sustain period (87% vs 72%, P <.01).

CONCLUSIONS

We increased documented FCR on our community pediatric hospital medicine service, including FCR for families with LOE, by implementing a nursing-completed EHR-FCR checklist supported by staff education, visual prompts, and interpreters.
Influence of nuclear factor κB and adenosine monophosphate-activated protein kinase on the vascular bed of the liver under the conditions of modeling chronic alcoholic hepatitis
Authors: Mykytenko A. О. , Akimov O. Y. , Yeroshenko G. A. , Neporada K. N.
Published: October 2024

Chronic alcohol use activates the transcription factor κB (NF-κB) in liver sinusoidal endothelial cells (LSECs), macrophages and other cells of the liver parenchyma, which controls the regulation of the expression of pro-inflammatory cytokines that activate signaling pathways of immune regulation of liver inflammation and vascular tone. AMP-activated protein kinase (AMPK) is an important immunometabolic regulatory factor in macrophages and, as a metabolic sensor, AMPK in vascular cells may be involved in the regulation of blood flow. The aim of the work was to find out the effect of modulators of the transcription factor κB and AMP-activated protein kinase on the morphometric parameters of the vascular bed of the liver of rats under the conditions of modeling chronic alcoholic hepatitis. Simulation of chronic alcoholic hepatitis leads to a violation of the exchange of metabolites between the central and interlobular veins, which creates prerequisites for the development of hypoxic damage to hepatocytes, as evidenced by a decrease in the diameters of lobular arterioles and venules. Administration of ammonium pyrrolidinedithiocarbamate and bacterial lipopolysaccharide, which affect NF-κB signaling under the conditions of modeling chronic alcoholic hepatitis, helps to restore the exchange of metabolites between the central and interlobular veins, which is evidenced by an increase in the lumens of lobular arterioles and venules. The introduction of phenformin and doxorubicin, which affect AMPK under the conditions of modeling chronic alcoholic hepatitis, prevents the development of hypoxic damage to hepatocytes, as evidenced by an increase in the diameters of lobular arteries and veins, and leads to intensification of interlobular blood circulation.
Morphological and functional spleen development in crossbreed rabbits
Authors: Myroshnychenko I. I. , Lieshchova M. A.
Published: October 2024

The accelerated growth of muscle mass in productive broiler breeds is often associated with delayed organ development of integral body systems, particularly the immune structures. The spleen is the largest secondary immune organ in the mammalian body and is responsible for initiating immune responses to blood-borne antigens. It can only perform this function successfully if all of its tissue components are fully morphologically and functionally mature. The spleen was studied in meat production rabbits (early maturing crossbreed Hyplus) at 1, 10, 20, 30, 60 and 90 days of age. Morphological studies included anatomical dissection, clarification of topography, determination of mass parameters, preparation of smears and histological sections. Spleen histological sections were stained with haematoxylin and eosin, according to Van Gieson, and impregnated with silver nitrate, followed by microscopy. Qualitative and quantitative indicators of spleen cellular and tissue component development were determined using ImageJ software. It was found that in crossbred rabbits the topography of the spleen corresponds to general anatomical principles of localisation, has a fixed place and is an anatomically formed organ. In day-old animals, the histological differentiation of the spleen is limited to the connective tissue stroma and the parenchyma. The organ's parenchyma is formed by reticular tissue, with hematopoietic and lymphoid cells among the cells, without differentiation into white and red pulp. In 10-day-old rabbits, the white pulp is represented by the periarterial lymphatic sheath (PALS) and marginal zones. Single primary lymphoid nodules without germinal centres are seen in the spleen from 20 days of age. By 30 days of age, the white splenic pulp has all the major structural and functional zones, including formed lymphoid nodules with germinal centres and mantle zones. During the second and third months of life, the spleen gradually increases the relative area of all white pulp functional zones, reaching a maximum at 90 days of age. In productive rabbits, the cellular composition of the splenic white pulp is represented by lymphocytes (small, medium, large), reticular cells, macrophages and plasma cells. During postnatal ontogenesis, the number of small lymphocytes increases in all white pulp functional zones, reaching maximum values in 90-day-old animals. On the contrary, the relative number of medium and large lymphocytes decreases. The number of reticulocytes in the periarterial lymphatic sheath and lymphoid nodules zones does not change significantly, and in the marginal zone it decreases substantially by the end of the study. The results of determining the timing of morphological and functional maturation of immunocompetent structures in the spleen of meat rabbits are of great biomedical and economic importance. They will serve as a control for comparing changes in rabbit spleen lymphoid tissues during the development of pathological processes, as well as under the influence of external factors.