bluuebunny/crossref_metadata_2025 huggingface dataset:
The Effect of Physical Activity Level of the Elderly on Depression and Quality of Life
Authors:   Selcuk University Faculty of Sport Sciences, Konya, Lök Sefa
Published: March 2023

Objective: The effect of physical activity level of the elderly on depression and quality of life was investigated in the study. Methods: This study was planned as a descriptive relational study. The study was carried out with individuals registered in a Family Health Center located in Selçuklu district of Konya province. It was collected from 154 elderly people who met the inclusion criteria of the study between February 1 and February 20, 2022 via Google Forms and face-to-face survey method. In the collection of data; Personal information form prepared by the researchers, questioning sociodemographic characteristics, International Physical Activity Questionnaire, Beck Depression Scale and SF 36 Quality of Life Scale were used. The results were evaluated at 95% confidence interval and p<0.05 significance level. Results: When the physical activity questionnaire, depression and quality of life levels of the elderly were evaluated, it was seen that 69.5% were physically inactive (inactive) and 30.5% had low physical activity levels (Low active). When the depression level of the elderly was evaluated, it was seen that 33.1% had mild depression, 42.9% had moderate depression and 24% had severe depression. The mean score of the mental sub-dimension of quality of life of the elderly was 35.0 ± 10.25 and the mean score of the physical sub-dimension was 35.18 ± 8.40. Conclusions: In the study examining the effects of depression and quality of life on physical activity levels in the elderly, men, single people, those who perceive their income poorly and those with chronic diseases were included in the risk group in terms of physical activity.
Possibilities assessment of the film cluster in the Kaliningrad Oblast functioning
Authors: Gorshkova A. A. , Kosinova M. I.
Published: March 2023

The purpose of the study is to assess the problems and prospects of a film cluster in the Kaliningrad Oblast of the Russian Federation.

   The following scientific research methods are used: analysis of scientific publications (articles), collection of primary information (conferences, round tables, foresight sessions, expert interviews), analysis of the regulatory framework. Empirical research methods are also involved: measuring quantitative data, conducting a survey and comparative analysis. The article substantiates the reasons why the Kaliningrad Oblast has been and remains an attractive region for film-makers. The analysis of available opportunities in the field of film production, film education, cast and other things is carried out. All aspects of the film industry are considered, including film festivals, film pitching and more. The work of the film commission is analyzed, in particular the rebate system introduced in 2017. The effectiveness of this system is evaluated in the light of the changes that occurred in it in 2020.
The role of the Internet in the modern life of children and teenagers: analysis of a sociological survey
Authors: Titor S. E.
Published: March 2023

Achievements in the field of technology, which serve as the foundation of the emerging modern information society, have led to the rapid development of the Internet – a global computer network. The Internet is a mean of social communication that has both positive and negative effects on the global community. Technology has taken a leading position in people’s lives, oftentimes transferring all activities of individuals into the online environment. This is why protection of minors from destructive online content is now becoming urgent. The information environment affects children’s upbringing, as they spend a lot of time online and, by using this opportunity to play and learn, become exposed to negative content. One of the consequences of informatisation has been the increasing role of mass media in the life of both national societies and the global community as a whole. For residents of developed countries, mass media have largely replaced interpersonal communication as the main source of adaptive and meaningful information and, serving as agents of socialisation, now play the key role in forming people’s worldview. Due to current political, economic, moral, and ethical transformations, the level of influence that the information environment has on younger users, is especially high. The findings of the study devoted to the assessment of this influence as well as children and teenagers’ behavior online in general are presented in the article.
Knowledge as the basis for forming the innovative potential of the organization staff
Authors: Ivanov I. N. , Orlova L. V.
Published: March 2023

The article is devoted to the development of innovative potential of the personnel based on knowledge management. The controversy surrounding the concept of innovative potential is highlighted. Current trends in human resources management are described. The interpretation of the aforementioned concept as a dynamic process of self-development of the personnel is substantiated. Key competencies, dynamic, organizational and absorbing capabilities of an enterprise that are being formed as part of the knowledge management system created at the enterprise are included in the list of the main characteristics of the stated potential. It is stressed that continuous staff training should be the main block of the system. The need to integrate the knowledge management system into the innovative business model of the organization is substantiated. Therefore, the company will transform into a self-learning one and eventually, with the maximum number of employees involved in the continuous training system, a company of intellectual resources that does not only accumulate but also capitalises knowledge. It is stated that corporate universities and educational centers established at organizations should become an effective way to accumulate and share corporate knowledge.
Digital ecosystem model of the agro-industrial complex
Authors: Korobeinikov D. A.
Published: March 2023

The study is devoted to modelling a sectoral ecosystem for the agro-industrial complex, incorporating into a single platform solution tools and mechanisms for the interaction between sectoral business structures in value chains as well as the proactive implementation of government functions for managing and supporting the industry. The ecosystem architecture has been developed and structured in terms of organizational, infrastructure, innovation, communication and logistics components. The role of the system actor and IT integrator is assigned to the Ministry of Agriculture of the Russian Federation. The main and additional functions of the digital platform are highlighted. A description of its product and service segments is provided. The options for implementing the process subsystem on the Gostech and GosOblako platforms as well as the Russian Agricultural Bank platform are assessed, the advantages of each solution presented. The importance of involving the research potential of departmental high education institutions and research institutes in the development of the ecosystem’s service segment is substantiated.
Regioselective Fluorohydrin Synthesis from Allylsilanes
Authors: Clover Alexie W. , Jones Adam P. , O'Neil Gregory
Published: March 2023

Allysilanes can be regioselectively transformed into the corresponding 3-silylfluorohydrin in good yield using a sequence of epoxidation followed by treatment with HF-Et3N with or without isolation of the intermediate epoxide. Various silicon-substitution is tolerated, resulting in a range of 2-fluoro-3-silylpropan-1ol products from this method. Whereas other fluorohydrin syntheses by epoxide opening using HF-Et3N generally require more forcing conditions (e.g. higher reaction temperature), opening of allylsilane-derived epoxides with this reagent occurs at room temperature. We attribute this rate acceleration along with the observed regioselectivity to a beta-silyl effect that stabilizes a proposed cationic intermediate. The use of enantioenriched epoxides produces similarly enantioenriched fluorohydrins suggestive of an SN2-type mechanism.
Redox-responsive peptide-based complex coacervates as delivery vehicles with controlled release of proteinous drugs
Authors: Wang Jiahua , Abbas Manzar , Huang Yu , Wang Junyou , Li Yuehua
Published: March 2023

Dynamic recruitment and releasing of specific intracellular proteins in active membraneless organelles formed by liquid-liquid phase separation is an emerging path for regulation of many intracellular tasks. However, how such dynamic phase separation process have impacts on the efficiency of proteinous drugs is still not well understood. Herein, we present a novel design of complex coacervates as in vitro MLOs models, made from small metabolites anionic molecules and simple arginine-rich peptides a cationic motif through LLPS. These complex coacervates show the assembly and disassembly behavior can be regulated by redox chemistry in three pathways, that help to control the releasing of therapeutic protein. A model proteinous drugs tissue plasminogen activator (tPA) can rapidly compartmentalize inside the complex coacervates, and coacervates formed from peptide conjugated with RGD motif mimic fibrinogen binding to activated platelets show selective binding to the thrombus site and thus enhance on-target efficacy of tPA. Then the burst release of tPA can be controlled by the redox-induced dissolution of coacervates. Our proof-of-principle complex coacervate system provide insights into the sequestration and release of proteinous drugs from advanced drug delivery system that could be central to the MLOs in living cells.
Temporal Differentiation of Extracellular Vesicles by Metabolic Glycan Labeling-Assisted Microfluidics
Authors: Wu Qiuyue , Wang Wencheng , Zhang Chi , You Zhenlong , Zeng Yinyan , Lu Yinzhu , Zhang Suhui , Li Xingrui , Yang Chaoyong , Song Yanling
Published: March 2023

Extracellular vesicle (EV)/exosome secretion is a dynamic process that tunes the cellular communication for response to internal and external cues. The selective enrichment of a newly synthesized EV/exosome has been hindered by the basic fact that all EVs/exosomes, new and old, share the similar inherent parameters and thus are indistinguishable. Here, we developed a method by cotranslational introduction of azide groups into EV/exosome proteins as a timestamp and label them with biotin tag by click chemistry, to separate the newly synthesized EVs/exosomes from preexisting populations by streptavidin-modified herringbone microfluidic chip. For mouse model of anti-PD-L1 immunotherapy, the level of newly synthesized PD-L1+ EVs detected by the developed approach was superior to the total PD-L1+ EVs from mixed time sources (quantified by classical method) for tumor progression. This method makes it possible to address the temporal characteristics of newly synthesized EVs/exosomes in cell and in vivo, for studying EV/exosome secretion to respond to specific stimuli.
1,6-Addition of Indolizines to para-Quinone Methides with Indium(III) Chloride as Catalyst
Authors: Rodrigues Jr Manoel , Senna Ana , Santos Hugo , Zeoly Lucas , Gomes Ralph , Coelho Fernando
Published: March 2023

A 1,6-addition of a wide variety of indolizines to para-quinone methides was developed using only 2 mol% indium chloride as a catalyst. The method successfully allows the regioselective addition of indolizines at positions 1 and 3 to p-quinone methides, leading to the formation of the desired products in excellent yields in most cases (up to 99%) under mild conitions and in short reaction time.
Nanometric chemical decomposition of infertile sub-Himalayan soils from Uttarakhand
Authors: Chinmaya KV , Sarbeena KP , Johny Vinitha , Pal Sumantra , Kumar Awnish , Rao Gowravaram Mohan , Ghosh Siddharth , Ghosh Moumita
Published: March 2023

We present the nanometric chemical decomposition o Himalayan agricultural soils. The motivation to use this state-of-the-art material characterisation in the soil is to reduce the testing cost while increasing the efficiency of the characterisation. In India, a bulk volume of soil is still required for the characterisation of agricultural soil. The fertility of micronutrient contents and crop supply capacity vary greatly depending on soil types, crop types, ecology, and agroclimatic variability. Since total levels of micronutrients are rarely predictive of the availability of a nutrient to plants, knowledge of the differences in soil micronutrients that are available to plants is essential for the sensible management of micronutrient fertility and toxicity. In the state of Uttarakhand, low levels of micro-nutrients in the soil are frighteningly common, and this issue is made worse by the fact that many current cultivars of important crops are extremely vulnerable to low mineral levels. These baseline results are to be used to inform local farmers about the potential remedies, costs, and consequential benefits and durability. We intend not to present a generalized or generalized solution. Therefore, we limit our soil sample collections to five arc minutes (8.6 square kilometers) and document variations and heterogeneity in the chemical components of the soil. In this study, we used scanning electron microscopy to chemically deconstruct the barren Himalayan soils from Uttarakhand. Aluminium, carbon, oxygen, and silicon were identified as the primary elements that contributed more than 5% of the total weight and atomic percentage. Other elements include less than 4% of iron, titanium, nitrogen, sodium, magnesium, chloride, phosphorus, sulfur, potassium, and calcium.
Examining the Influence of Desalinated Water on Iodine Concentration in Tap Water in Israel
Authors: Rosen Vasiliy V. , Gal Orit , Andrushchenko Yulianna , Chen Yona
Published: March 2023

In Israel, desalinated water is a major source of drinking water, blended with water from local wells and Lake Kinneret. Studies have shown that iodine concentrations in the water provided by authorities may not accurately reflect levels reaching end-users. We analyzed the iodine content in 21 tap water and several natural water samples collected from different localities across Israel during May-June 2021, using an improved method of ICP-MS. Our results showed that it is possible to distinguish between sample groups based on iodine concentration, water hardness, and Ca/Mg ratio. The median values for four groups of tap waters ranged from 0.3 to 12.3 g I L-1, which is lower than the iodine concentration in Israeli tap water reported previously by other researchers. Calculations based on typical consumption suggest that the water can provide no more than 3.39% of the recommended dietary allowance level. Additionally, we also analyzed 13 samples of post-treated desalinated water from three of the largest Israeli desalination plants. The results indicate that these waters comply with industrial specifications but contain only trace concentrations of iodine and much less magnesium than recommended by different public health authorities for public consumption of drinking water.
Ultrabright two-photon excitable red-emissive fluorogenic probes for fast and wash-free bioorthogonal labeling in live cells
Authors: Auvray Marie , Naud-Martin Delphine , Fontaine Gaëlle , Bolze Frédéric , Clavier Gilles , Mahuteau-Betzer Florence
Published: March 2023

Fluorogenic bioorthogonal reactions are promising tools for tracking small molecules or biomolecules in living organisms. Two-photon excitation, by shifting absorption towards the red, significantly increases the signal-to-noise ratio and decreases photodamages, while allowing to image about 10 times deeper than with a confocal. However, efficient two-photon excitable fluorogenic probes are currently lacking. We report here the design and synthesis of fluorogenic probes based on a two-photon excitable fluorophore and a tetrazine quenching moiety. Among our series of 6 new probes, our best candidate possesses a turn-on ratio of 22 and an impressive kinetic rate constant of 1.1x103M-1s-1, about 10 times higher than that reported for the fluorogenic iEDDA reaction with bicyclo[6.1.0]no-4-yn-9yl)methanol (BCN). Live-cell imaging under two-photon excitation confirmed that there was no need for washing to monitor the reaction between BCN and this probe with high-contrast images. The high two-photon brightness of the clicked adduct (362 GM) allows the use of a weak laser power compatible with in vivo imaging.
Spiroindoles as Intermediates/Products in Transition Metal Catalyzed Dearomatization of Indoles
Authors: Buttard Floris , Guinchard Xavier
Published: March 2023

Spirocyclic indole derivatives are fascinating tridimensional molecular scaffolds, from both a synthetic and biological point of view. Among the diversity of strategies developed to access this kind of structures, transition metal catalysis recently led to impressive advances, especially in order to tame the unique reactivity of the dearomatized spirocyclic intermediates. These species can indeed evolve towards both spirocyclic or non-spirocyclic products through rearomatization-driven processes which are at the same time highly challenging to control but also source of a large structural diversity. This review highlights the most prominent methods of the last decade allowing to trigger a spirocyclization on indole derivatives tethered with a transition metal-activable functional group, leading to both spirocyclic and rearomatized products. The discussion is particularly focused on the reactivity and the complex mechanistic features regarding the evolution of the spiroindoleninium intermediate, highly dependent on the catalytic system.
A multiplexed siRNA screen identifies key kinase signaling networks of brain glia
Authors: Kim Jong-Heon , Han Jin , Afridi Ruqayya , Kim Jae-Hong , Rahman Md Habibur , Park Dong Ho , Lee Won Suk , Song Gyun Jee , Suk Kyoungho
Published: March 2023

The dynamic behaviors of brain glial cells in various neuroinflammatory conditions and neurological disorders have been reported; however, little is known about the underlying intracellular signaling pathways. Here, we developed a multiplexed kinome-wide siRNA screen to identify the kinases regulating several inflammatory phenotypes of mouse glial cells in culture, including inflammatory activation, migration, and phagocytosis of glia. Subsequent proof-of-concept experiments involving genetic and pharmacological inhibitions indicated the importance of T-cell receptor signaling components in microglial activation and a metabolic shift from glycolysis to oxidative phosphorylation in astrocyte migration. This time- and cost-effective multiplexed kinome siRNA screen efficiently provides exploitable drug targets and novel insight into the mechanisms underlying the phenotypic regulation of glial cells and neuroinflammation. Moreover, the kinases identified in this screen may be relevant in other inflammatory diseases and cancer, wherein kinases play a critical role in disease signaling pathways.
Development and Validation of the Korean Work Addiction Scale (K-WAS) Based on Behavioral Addiction Criteria
Authors:   Korean Academy Of Management, Cha Oona , Lee Hwaryung
Published: March 2023

Conceptualizing work addiction as a form of behavioral addiction, this study attempts to develop and validate the Korean Work Addiction Scale or K-WAS based on Griffiths’ (2005) behavioral addiction criteria, i.e., salience, mood modification, tolerance, conflict, withdrawal, and relapse. The preliminary items for K-WAS were developed based on two main sources: (1) data from seven existing workaholism or work addiction scales (WorkBat, WorkBat-B&P, WorkBat-Han, WART, DUWAS, BWAS, and WAQ) and (2) data collected through in-depth interviews and open-ended surveys from Korean workers (employees and self-employed) on their experiences with and related to work addiction. An 18-item K-WAS was derived as a result and analyses showed that the proposed hierarchical secondary factor model with six sub-factors has a good fit. In addition, K-WAS was found to have low to moderate positive correlations with work engagement and burnout but weak or nonsignificant correlations with thriving at work, job satisfaction, subjective well-being, and positive affect, demonstrating convergent and discriminant validity. Based on a critical review of extensive workaholism and work addiction studies and scales, this study provides suggestions for developing work addiction items and discusses the usefulness of applying the behavioral addiction framework in work addiction studies—i.e., how it can help refine the work addiction concept and its subdimensions and integrate relevant research. Further implications and limitations of the study are also discussed.
Analysis Of Moves and Tenses on Abstract Article Published at Journals
Authors: Putra Hendra
Published: March 2023

An abstract has an important role in the research article. Generally, if the researcher wants to submit the article the first thing that must be done is to submit an abstract. This article aims to identify the moving structure of English abstracts of researcher’s articles from many sources that were published started from 2011 to 2021, to identify of applying tense and disagreement of subject and tense in writing abstract article. This study employed a genre analysis approach. As data collection techniques are used 10 abstract articles from the journal were published and then analyzed by using a moving structure from Hyland and Swales & Feak. The result can be revealed that they are 7 abstract articles that applied the introduction, 9 abstract articles that applied purpose, 9 articles that applied method, and 10 abstract articles that applied product move then there are 4 abstract articles applied conclusion move. In applying tense, the most used is simple present tense. It can be concluded that the most applied move is the product in writing an abstract article then the most used tense is in the simple present tense in writing an abstract article.
SYNTHESIS, CRYSTAL STRUCTURE AND DFT STUDY OF ETHYL 5-(TRIMETHYLSILYL)-1-1H-PYRAZOLE-3-CARBOXYLATE
Authors: Zhao C.-S. , Wang Yuan
Published: March 2023

Ethyl 5-(trimethylsilyl)-1-1H-pyrazole-3-carboxylate is a broad-spectrum bioactive derivative of pyrazole. In this study, this compound was synthesized, and its purity was analyzed using IR, 1H NMR, 13C NMR, and MS. At the same time, the single crystal of the title compound was determined through X-ray diffraction analysis. Moreover, the optimal structure of the molecule was calculated using density functional theory (DFT) calculations and compared with the X-ray diffraction data. The results of conformational analysis revealed that the optimized molecular structure obtained from DFT calculations was equivalent to that obtained from X-ray diffraction analysis. The crystal structure determined using single crystal diffraction is consistent with that of the title compound. In addition, the molecular electrostatic potential and leading molecular orbitals of the title compound were further investigated using DFT calculations, and insights into some of the physical and chemical properties of the compound were achieved.
On the Legal Nature of Regional Integration Associations
Authors:   Kazan Federal University, Kazan, 420008 Russia, Bodurova G.G.
Published: March 2023

This article deals with the problem of defining the legal nature of integration associations, mainly regional, as well as with the issue of revealing their major role in world affairs. Notably, it is possible to clarify the legal essence of these entities if their individual features distinguishing integration associations from the existing form of interstate cooperation, in particular international organizations, are known. Of special interest are the characteristics of such regional integration associations that are based on larger associations, such as the Eurasian Economic Union, a trade agreement between several post-Soviet states, and the European Union, a political and economic association of European states. The relations of an international character developing during the interstate cooperation within the framework of regional integration associations were described with the help of the comparative and analytical methods. A comprehensive legal definition of the concept of regional integration associations was provided based on their unique features. The latter were analyzed in detail. The considered forms of interstate cooperation were compared with international organizations. The results obtained show that an integration association is a special form of interstate cooperation of a regional nature, which is aimed at the development of foreign economic relations between member states.
A Review of the Interregional Scientific and Practical Round-Table Discussion “Interregional and Intermunicipal Collaboration under the Conditions of Environmental Challenges in the Volga Region”
Authors:   Kazan Federal University, Kazan, 420008 Russia, Safin Z.F. , Khamaev A.K. ,   State Council of the Republic of Tatarstan, Kazan, 420060 Russia, Tarkhanova A.A. ,   State Council of the Republic of Tatarstan, Kazan, 420060 Russia, Sultanov E.B. ,   Kazan Federal University, Kazan, 420008 Russia, Luneva E.V. ,   Kazan Federal University, Kazan, 420008 Russia
Published: March 2023

This review summarizes the keynote speeches and some presentations on specific problems delivered by the participants of the interregional scientific and practical round-table discussion “Interregional and Intermunicipal Collaboration under the Conditions of Environmental Challenges in the Volga Region” held on June 29, 2021 at Kazan Federal University. The event was attended by representatives of the local government authorities of the Republic of Tatarstan that are directly working on ensuring the environmental safety, as well as by legal scholars and applied researchers of the Volga Federal District. Based on the exchange of views, the Law Department of Kazan Federal University drafted and presented its interdiscip¬linary project “An organizational and legal mechanism of tackling ecological challenges under the conditions of spatial development of the Volga region and the Caspian ecosystems: Convergence and divergence of the legal systems of Russia, Azerbaijan, Iran, Kazakhstan, and Turkmenistan (EcoINTERVolga–Caspian)”. The article ends with a resolution adopted as a follow-up of the fruitful joint work of all participants.
On the Termination of the Professional Activity of Athletes
Authors:   Kazan Federal University, Kazan, 420008 Russia, Vaskevich V.P.
Published: March 2023

In this article, legal issues associated with the termination of the professional activity of an athlete are considered. The results obtained show that there are no specific procedures for terminating professional activities in sports, but it does not follow from this circumstance that there is no need to comply with the already established obligations at all. From a legal perspective, an athlete terminates their professional activity when they decide to stop taking part in sports competitions that are specific to professional sports activities. The article draws attention to the fact that an athlete’s refusal to be included in the number of participants, any temporary restrictions on their admission, and their disqualification do not directly confirm the termination of their professional activity. In addition, there is no reason to consider the closure of a sports club or league (federation) as a special basis for terminating an athlete’s activities. The central provision of the Olympic Charter proclaims the right of every person, not only sports organizations or states, to play sports, and the latter must contribute to the realization of this right. Civil law has sufficient tools for leveraging the rules in sports to achieve this important social and humanitarian goal.
On Certain Fixed Point Theorems in Sb-Metric Spaces With Applications
Authors: Mangapathi N. , Rao B. Srinuvasa , Rao K.R.K. , Pasha M.I.
Published: March 2023

In this paper, we introduce the notion of generalized (α, φ, ψ)- Geraghty contractive type mappings in the setup of Sb-metric spaces and α-orbital admissible mappings with respect to φ. Furthermore, the fixed-point theorems for such mappings in complete Sb-metric spaces are proven without assuming the subadditivity of ψ. Some examples are provided for supporting of our main results. Also, we gave an application to integral equations as well as Homotopy.
Solving Multi-Objective Linear Fractional Programming Problems by Novel Methods
Authors: Abdalla Snoor O. , Abdullah Ronak M.
Published: March 2023

In this paper, we suggested two new techniques for transforming multi-objective linear fractional programming problems into single-objective linear fractional programming problems (SOLFPP) and then solving them by methods of SOLFPP. Illustrative numerical examples are presented for demonstration purposes. Also, the obtained results are compared with another method studied previously.
Forensic Analysis of Faces on Low-Quality Images using Detection and Recognition Methods
Authors: Kristanto Verry Noval , Riadi Imam , Prayudi Yudi
Published: March 2023

Facial recognition is an essential aspect of conducting criminal action investigations. Captured images from the camera or the recording video can reveal the perpetrator's identity if their faces are deliberately or accidentally captured. However, many of these digital imagery results display the results of image quality that is not good when seen by the human eye. Hence, the facial recognition process becomes more complex and takes longer. This research aims to analyze face recognition on a low-quality image with noise, blur and brightness problem to help digital forensic investigator do an investigation in recognizing faces that the human eye can’t do. The Viola-Jones algorithm method has several processes such as the Haar feature, integral image, adaboost, and cascade classifier for detecting a face in an image. Detected face will be passed to the next process for recognition call Fisher’s Linear Discriminant (FLD),  Local Binary Pattern’s (LBP) and Principal Component analysis (PCA). The software's facial recognition feature shows one of the images in the database that the program suspects has the same face as the analyzed face image. In conclusion, from the analysis we determined that LBP approach is the best among the other recognition methods for blur and brightness problem, bet found PCA method is the best for recognize face in noise problem. The software's facial recognition feature shows one of the images in the database that the program suspects has the same face as the analyzed face image. The position of the face object in the image, whether or not there is an additional object that was not previously included in the image in the dataset, as well as the brightness level of an image and the color of the face's skin, all affect the accuracy rates.
Coleção Livro Didático Digital (CLDD) - Teorias do Movimento e Educação Física
Authors: Pinto Ricardo Figueiredo
Published: March 2023

Estudo das teorias do movimento humano na educação física, psicomotricidade, comportamento motor, aprendizagem motora e desenvolvimento motor.
AVALIAÇÃO CLÍNICA E LABORATORIAL DE CRIANÇAS COM TOXOPLASMOSE CONGÊNITA EM GURUPI-TOCANTINS
Authors: Santos Felipe Rudá Silva , Silva Marcos Gontijo da
Published: March 2023

Pretende-se abordar a toxoplasmose congênita, doença que pode determinar a morte do concepto ou causar alterações que agravam o prognóstico neonatal dos sobreviventes. Objetivou-se realizar triagem neonatal em crianças de mulheres que tiveram toxoplasmose gestacional em Gurupi, Tocantins. Adotou-se como metodologia uma pesquisa de campo onde as grávidas que concordaram em participar da pesquisa, tiveram seus filhos encaminhados para coleta de sangue periférico. Foram submetidos à análise os prontuários e, avaliação clínica dos recém-nascidos, onde a variável de análise dependente foi o diagnóstico positivo e as variáveis independentes foram sexo, peso, comprimento, sequelas clínicas, sinais e sintomas, sorologia da mãe, perímetro cefálico e tipo de parto. Observou-se após a sorologia das mães para toxoplasmose, a soroprevalência pontual, taxa de transmissão, porcentagem de doentes e avaliação clínica dos recém-nascidos. Obteve-se como resultado soroprevalência pontual de 5,3%, taxa de transmissão de 26,92%, porcentagem ausente de doentes, já que não foram constatadas alterações na avaliação clínica dos recém-nascidos. Concluiu-se que os recém-nascidos com toxoplasmose congênita não apresentaram alterações clínicas, porém a possibilidade de manifestação tardia da doença não deve ser descartada.

Palavras-chave: Toxoplasmose congênita, Recém-nascidos, Grávidas.
Expression of Ki67and p53 Proteins in Hodgkin ׳s Lymphomas and Non Hodgkin׳s Lymphomapatients using immunohistochemistry
Authors: Alaswad Elham A.
Published: March 2023

Background: Hodgkin’s lymphoma (HL) and Non-Hodgkin’s lymphoma( NHL) are characterized by a profound disturbance of the cell cycle and apoptosis regulation., Ki-67 and P53 expression has been shown to be associated with adverse clinical outcome in a variety of malignant hematological disorders, including HL and NHL. Aim: This study aimed to clarify Ki-67 expression level and its correlation with p53 expression in HL and NHL. Material and methods: total of 28 newly diagnosed HL and NHL patients were investigated for Ki-67 expression and its correlation to p53 expression by immunohistochemical technique. Results: Ki-67 expression was observed in 46.7 % of HL patients while 7.7% of NHL patients gave positive Ki-67 expression. A significant Association between thetype of lymphoma and Ki67 expression (p<0.05) noticed. The histopathologcal type appeared to be 57.1% mixed cellularity and 37.5% of them showed positive Ki67 expression , while 42.9 % were intermediate grade and only 16.7 % showed positive Ki67 expression . There were no significant correlation between the histopathologcal type and Ki67 expression. only 4 ( 14.3 %) of the cases were p53 negative ,while the rest 24 cases were p53 positive ,and the majority ( 66.7% ) were within score 2 . Eight cases ( 28.6 %) were positive for Ki-67 and p53 , Ki-67 was negative in 71.4% cases , and four of them were negative for p53 and the rest 16 ( 80% )cases were p53 positive .A significant correlation was found between p53 and Ki-67 expression where( r=0.608,p=0.001) . conclusion : it is suggested that immunohistochemical studies of p53 and Ki-67 expression in tumor tissue including HL and NHL can help in monitoring of patients at risk, and the markers may aid in controlling the progression of lymphoma and detect the degree of aggressiveness of the disease to give suitable treatment and management of patients .
Molecular Investigation of Genetic Polymorphisms in Type 2 Diabetic Patients Using Random Amplified Polymorphic DNA (RAPD-PCR)
Authors: Zahid Rawaa A.
Published: March 2023

To find DNA markers associated with Type 2 diabetes mellitus (T2D) using RAPD-PCR (Random amplified polymorphic DNA-Polymerase Chain Reaction). Peripheral blood samples were collected from 12 unrelated Iraqis with type 2 diabetes mellitus and 10 apparently healthy individuals (control subjects). DNA was extracted and amplified using RAPD-PCR. Out of the 16 primers used, 3 did not produce amplification patterns. Seven primers produced monomorphic bands while 6 primers namely A10, A18, C5, D20, R3 and R4 produced polymorphic DNA profiles. The highest discriminatory power was produced by primers A18 and D20 reaching 25%. Primer D20 produced the highest number of bands (16) and largest molecular weight band 2.470Kb whilst primer A10 produced the lowest number of bands (3) and primer R4 the smallest molecular weight band of 0.296Kb. Furthermore a band of 1.056 Kb was produced by primer R4 with frequency of 100% in diabetic patients and total absence in control subjects. The total length of the genome screened was approximately 118.661Kb, 40% of which represent polymorphisms. In conclusion Polymorphisms between diabetic patients and control subjects can be detected by RAPD-PCR and DNA markers associated with type 2 diabetes mellitus can be found using the same technique
Study on organic matter decomposition and siderophore production of rhizobacteria isolated from black pepper grown in Loc Ninh, Binh Phuoc province, Vietnam
Authors: Ha Bao Son  , Dang Thi Ngoc Thanh  , Huynh Nguyen Van Anh  , Pham Thi Thu Ly  , Hoang Minh Tam
Published: March 2023

This study was carried out determining capability of organic compound decomposition and siderophore synthesis of 39 plant growth promotion rhizobacteria strains isolated from rhizosphere of black pepper (Piper nigrum L.) in a previous study. The ability to degrade organic compounds including proteins, lipids, cellulose and chitin was investigated by agar well diffusion method. The ability to produce siderophore was qualified by liquid CAS method and strains with good results were further investigated by PS-CAS agar plate method. The results showed that the number of bacterial strains capable of degrading protein, cellulose, chitin and lipid were 37, 27, 16 and 6, respectively. Twenty-two strains changed color of CAS agar, of which 6 strains had a band width of 4.5 cm. The seven best strains identified were Proteus mirabilis (LD2), Bacillus megaterium (LT4), B. subtilis (LT2), B. cereus (LD7, LD8, LD16, LT19) by Matrix Assisted Laser Desorption/Ionization-Time of Flight method. These were plant growth-promoting rhizobacteria that had been reported on potential applications in agriculture.
Geometric Morphometric Analysis of Skull in Honamli, Hair, Kilis and Saanen Goat Using Dorsal Landmarks
Authors: YAPRAK Ahmet , ÖZGEL Özcan , DEMİRASLAN Yasin
Published: March 2023

The aim of the study was to analyze the dorsal aspect of the skulls of Honamli, Hair, Kilis and Saanen goats by geometric morphometric method. A total of 48 adult goat skulls, 6 male and 6 female, were used for each breed. After the skulls were photographed dorsally, 10 homologous landmarks were marked. As a result of our study, the degree of dorsal separation of the skulls according to sex was found to be limited. Nevertheless, significant separation was seen in the Honamli skulls of females and in the Honamli and Saanen skulls of males. This information may serve as a reference for the skull remains of ruminants.
Effectiveness of Chamomile and Ginger on Reducing Pain Intensity in Active Phase I Partus
Authors: Joharmi Joharmi , Pane Herviza Wulandary , Hasanah Ustifina , Raudha Raudha
Published: March 2023

Aromatherapy is a method that uses essential compounds to improve physical, emotional, and spiritual health. Another effect is to reduce pain and anxiety. Several studies have demonstrated the effectiveness of aromatherapy for pain and stress in maternity patients. Chamomile is one of the herbal medicinal plants that has long been known in human life. Chamomile that has been processed is generally used to treat diseases experienced by humans, namely fever, inflammation, muscle spasms, menstrual disorders, insomnia, wounds, digestive disorders, rheumatic pain, and hemorrhoids. Chamomile oil is used extensively in cosmetics and aromatherapy. Many chamomile treatments can be developed; the most famous medicine is chamomile herbal aromatherapy. This study used a posttest-only control group design with 44 respondents, all pregnant women whose gestational age was between 38-41 weeks.The results of therapy in the form of a decrease in pain in the chamomile oil therapy group compared to the ginger group turned out to have a significant difference. The pain intensity of some respondents before ginger therapy was moderate pain, namely, 12 people (54%) and mild pain, 10 people (46%). After ginger therapy, the pain intensity of respondents experienced no pain, namely as many as 10 people (46%), mild pain in as many as 7 people (32%), and moderate pain in as many as 5 people (22%).Value < 0.05, whereas with ginger, the p-value was 0.049, also the p-value < 0.05, it can be interpreted that chamomile and ginger are both effective in reducing the intensity of labor pain during the active phase I stage, but chamomile is more effective compared to ginger, because the smaller the p-value, the greater the effectiveness, as shown in the table above. There is a significant difference between chamomile and ginger oil in reducing pain.

 
QUANTITATIVE VISITORS' ANALISYS TO THE FARM CULTURAL PARK MUSEUM (FCP), IN FAVARA, SICILY (ITALY)
Authors:   University of Cordoba Faculty of Law and Business & Economic Sciences, Department of Applied Economics, Cordoba, Spain, FRUET-CARDOZO J. Vicente , BORSELLINO Lucía ,   University of Cordoba, Faculty of Law and Business & Economic Sciences, Department of Applied Economics, Cordoba, Spain, VALVERDE-RODA José ,   University of Almería, Department of Economics and Business, Almeria, Spain, CARIDAD-LOPEZ DEL RIO Lorena ,   University of Cordoba, Faculty of Law and Business & Economic Sciences, Department of Statistics and Operational Research, Córdoba, Spain
Published: March 2023

This study focuses on one line of cultural tourism. Specifically, in a contemporary art museum, located in Favara, (Agrigento), Sicily, called Farm Cultural Park (FCP) Museum. The study analyzes the profile of FCP visitors, from the perspective of cultural, sustainable and participatory tourism. A total of 302 surveys were conducted during June, July and August 2020. Therefore, it must be considered that they were the first months after the confinement decreed in the country due to Covid-19, with all the obvious difficulties. Data analysis was carried out with the SPSS statistical program in its version 26. The methodology was based on a structural equation model (SEM), with different causal relationships among the analyzed constructs. Tourists came with the precise interest of visiting an open museum, with a very high social and participatory component. The visitors were fully satisfied by the staff who welcomed them. A medium-low level of spending was observed, linked to consumption inside the museum. And, unfavorable opinions were expressed on a lack of signage to arrive in FCP. The final results support the influence of preferences upon satisfaction, which originates attitudinal loyalty. Therefore, it would be very important for Sicily to show that tourism on the island could not be seasonal, due to the magnificent climatic conditions that prevail throughout the year. It would also be crucial to expand research on the synergies of cultural tourism that could be generated between the Valley of the Temples, in Agrigento, and the FCP, in Favara. In this way, a greater range of sites would be offered that concern various interests and ideas, both for the department’s business community, as well as for tourists. The corollary of these actions would be to increase the presence of Agrigento on the map of international cultural tourism. All this should be capable of transforming, enhancing and making known the richness of territorial diversity, traditions and historical and environmental contexts, first in the department of Agrigento, and later, throughout the island.
ASSESSMENT OF FACTORS AFFECTING SPIRITUAL CULTURAL TOURISM AN GIANG PROVINCE, VIETNAM
Authors:   An Giang University, Vietnam National University Ho Chi Minh City, Department of Geography, Faculty of Pedagogy, An Giang Province, Vietnam, TO Chau Minh
Published: March 2023

Cultural and spiritual tourism activities are the development trend of Vietnam tourism. It not only brings socio-economic benefits to the locality but also contributes to improving the spiritual life of tourists. An Giang province, Vietnam, has many humanistic tourism resources, which is a condition for developing spiritual and cultural tourism. Exploiting spiritual and cultural tourism in An Giang has been going on for a long time, but many issues still need attention. The article uses surveying 120 tourists on the conditions for developing spiritual and cultural tourism and assessing the factors affecting the development of spiritual and cultural tourism in An Giang province. Research results analyzed by SPSS 20.0 show five factors influencing the growth of spiritual and cultural tourism in An Giang province: service prices, human resources and amenities; security, order and safety; goods and environmental protection; transportation; and facilities. The analysis results show that the conditions for developing spiritual and cultural tourism in An Giang province are only quite average. The article has proposed some development solutions for this type of tourism.
Влияние 5-(4-аминофенил)-4-амино-1,2,4-триазол-3(2H)-тиона на гладкомышечные клетки аорты крыс
Authors: Мирзаева Юлдузхон Тахиржоновна , Исмаилова Д. С. , Шкинев А. В. , Усманов П. Б. , Элмурадов Б. Ж.
Published: March 2023

На сегментах аорты крыс с использованием механографического устройства изучено действие нового производного 1,2,4-триазола (5-(4-аминофенил)-4-амино-1,2,4-триазол-3(2H)-тиона, Д-280). Показано, что в интервале концентраций 1 – 100 мкМ Д-280 не оказывал влияния на базальный тонус сегментов. Однако, после предварительной стимуляции сегментов аорты фенилэфрином или гиперкалиевыми растворами, Д-280 вызывал дозозависимое расслабление с близкими значениями IC50, равными 27,6 ± 4,1 и 25,1 ± 3,6 мкМ, соответственно.
Oedipus’s Responsibility: The Problem of Moral Luck According to Bernard Williams and Thomas Nagel
Authors: Rego Rui
Published: March 2023

In mythology, Oedipus is impelled, by destiny or fate, to perform a set of actions. Given that he is not responsible for his fate or luck, is he responsible for his crimes? Can moral judgments be independent of luck, chance or fortune? Nagel suggests an example: two agents (with the same intentions, desires, beliefs, etc.) shoot someone. The first agent hits the target, the second agent does not hit it because, luckily, a bird crossed the path of the bullet fired. Both agents wanted to hit their targets, but by the interference of chance or luck only one of them hits it: do we judge both agents in the same way, morally speaking? It seems that the moral responsibility of an agent for his actions is inseparable from a principle of control of the agent over his actions. However, when we analyse the object of moral judgment (agents, actions), our assessment varies according to elements of luck (constitutive, circumstantial, resulting, causal). Does luck introduce a paradox into the core of moral judgments (Nagel's thesis), limiting the very concept of morality (as Williams argues)? In this paper, I argue for the need to evaluate agents and actions morally regardless of whether they are subjected to luck.
Consanguineous Marriage, Health Literacy and Fatalism Levels of Different Generations: A Descriptive-Correlational Study in A Sample from Turkey
Authors: YILDIZ Metin , YILDIRIM Mehmet Salih , ELKOCA Ayse , SARPDAĞI Yakup , AYDIN Muhammet Ali , KABAK Tuğçe , DEGE Gökhan
Published: March 2023

Objective: This research was conducted to determine consanguineous marriage, health literacy, and fatalism levels of different generations and examine their relationship. Materials and Methods: This descriptive-correlational study was conducted with 463 individuals living in XXX between September 2021-March 2022. Results: Significant differences were found between the individuals' Consanguineous Marriage Attitude Scale, Health Literacy Scale, and Fatalism Tendency Scale total score means and their generation (p