bluuebunny/crossref_metadata_2025 huggingface dataset:
A Method for Recognizing Fatigue Driving Based on Dempster‐Shafer Theory and Fuzzy Neural Network
Authors: Zhu WenBo , Yang Huicheng , Jin Yi , Liu Bingyou
Published: February 2017

This study proposes a method based on Dempster‐Shafer theory (DST) and fuzzy neural network (FNN) to improve the reliability of recognizing fatigue driving. This method measures driving states using multifeature fusion. First, FNN is introduced to obtain the basic probability assignment (BPA) of each piece of evidence given the lack of a general solution to the definition of BPA function. Second, a modified algorithm that revises conflict evidence is proposed to reduce unreasonable fusion results when unreliable information exists. Finally, the recognition result is given according to the combination of revised evidence based on Dempster’s rule. Experiment results demonstrate that the recognition method proposed in this paper can obtain reasonable results with the combination of information given by multiple features. The proposed method can also effectively and accurately describe driving states.
Molecular Descriptors of Nanotube, Oxide, Silicate, and Triangulene Networks
Authors: Gao Wei , Siddiqui Muhammad Kamran
Published: February 2017

A topological index is a real number associated with chemical constitution purporting for correlation of chemical structure with various physical properties, chemical reactivity, or biological activity. The concept of hyper Zagreb index, first multiple Zagreb index, second multiple Zagreb index, and Zagreb polynomials was established in chemical graph theory based on vertex degrees. It is reported that these indices are useful in the study of anti-inflammatory activities of certain chemical networks. In this paper, we study carbon nanotube networks which are motivated by molecular structure of regular hexagonal lattice and also studied interconnection networks which are motivated by molecular structure of a chemical compound SiO4. We determine hyper Zagreb index, first multiple Zagreb index, second multiple Zagreb index, and Zagreb polynomials for some important class of carbon nanotube networks, dominating oxide network, dominating silicate network, and regular triangulene oxide network.
A Mobile Network Planning Tool Based on Data Analytics
Authors: Moysen Jessica , Giupponi Lorenza , Mangues-Bafalluy Josep
Published: February 2017

Planning future mobile networks entails multiple challenges due to the high complexity of the network to be managed. Beyond 4G and 5G networks are expected to be characterized by a high densification of nodes and heterogeneity of layers, applications, and Radio Access Technologies (RAT). In this context, a network planning tool capable of dealing with this complexity is highly convenient. The objective is to exploit the information produced by and already available in the network to properly deploy, configure, and optimise network nodes. This work presents such a smart network planning tool that exploits Machine Learning (ML) techniques. The proposed approach is able to predict the Quality of Service (QoS) experienced by the users based on the measurement history of the network. We select Physical Resource Block (PRB) per Megabit (Mb) as our main QoS indicator to optimise, since minimizing this metric allows offering the same service to users by consuming less resources, so, being more cost-effective. Two cases of study are considered in order to evaluate the performance of the proposed scheme, one to smartly plan the small cell deployment in a dense indoor scenario and a second one to timely face a detected fault in a macrocell network.
Comparative Hepatotoxicity of Fluconazole, Ketoconazole, Itraconazole, Terbinafine, and Griseofulvin in Rats
Authors: Khoza Star , Moyo Ishmael , Ncube Denver
Published: February 2017

Oral ketoconazole was recently the subject of regulatory safety warnings because of its association with increased risk of inducing hepatic injury. However, the relative hepatotoxicity of antifungal agents has not been clearly established. The aim of this study was to compare the hepatotoxicity induced by five commonly prescribed oral antifungal agents. Rats were treated with therapeutic oral doses of griseofulvin, fluconazole, itraconazole, ketoconazole, and terbinafine. After 14 days, only ketoconazole had significantly higher ALT levels (p=0.0017) and AST levels (p=0.0008) than the control group. After 28 days, ALT levels were highest in the rats treated with ketoconazole followed by itraconazole, fluconazole, griseofulvin, and terbinafine, respectively. The AST levels were highest in the rats treated with ketoconazole followed by itraconazole, fluconazole, terbinafine, and griseofulvin, respectively. All drugs significantly elevated ALP levels after 14 days and 28 days of treatment (p<0.0001). The liver enzyme levels suggested that ketoconazole had the highest risk in causing liver injury followed by itraconazole, fluconazole, terbinafine, and griseofulvin. However, histopathological changes revealed that fluconazole was the most hepatotoxic, followed by ketoconazole, itraconazole, terbinafine, and griseofulvin, respectively. Given the poor correlation between liver enzymes and the extent of liver injury, it is important to confirm liver injury through histological examination.
Capacity of Human Dental Follicle Cells to Differentiate into Neural CellsIn Vitro
Authors: Kanao Shingo , Ogura Naomi , Takahashi Kosuke , Ito Ko , Suemitsu Masaaki , Kuyama Kayo , Kondoh Toshirou
Published: February 2017

The dental follicle is an ectomesenchymal tissue surrounding the developing tooth germ. Human dental follicle cells (hDFCs) have the capacity to commit to differentiation into multiple cell types. Here we investigated the capacity of hDFCs to differentiate into neural cells and the efficiency of a two-step strategy involving floating neurosphere-like bodies for neural differentiation. Undifferentiated hDFCs showed a spindle-like morphology and were positive for neural markers such as nestin,β-III-tubulin, and S100β. The cellular morphology of several cells was neuronal-like including branched dendrite-like processes and neurites. Next, hDFCs were used for neurosphere formation in serum-free medium containing basic fibroblast growth factor, epidermal growth factor, and B27 supplement. The number of cells with neuronal-like morphology and that were strongly positive for neural markers increased with sphere formation. Gene expression of neural markers also increased in hDFCs with sphere formation. Next, gene expression of neural markers was examined in hDFCs during neuronal differentiation after sphere formation. Expression ofMusashi-1andMusashi-2,MAP2,GFAP,MBP, andSOX10was upregulated in hDFCs undergoing neuronal differentiation via neurospheres, whereas expression ofnestinand β-III-tubulinwas downregulated. In conclusion, hDFCs may be another optimal source of neural/glial cells for cell-based therapies to treat neurological diseases.
Investigation of the Effects of Submerged Arc Welding Process Parameters on the Mechanical Properties of Pressure Vessel Steel ASTM A283 Grade A
Authors: Peasura Prachya
Published: February 2017

The pressure vessel steel is used in boilers and pressure vessel structure applications. This research studied the effects of submerged arc welding (SAW) process parameters on the mechanical properties of this steel. The weld sample originated from ASTM A283 grade A sheet of 6.00-millimeter thickness. The welding sample was treated using SAW with the variation of three process factors. For the first factor, welding currents of 260, 270, and 280 amperes were investigated. The second factor assessed the travel speed, which was tested at both 10 and 11 millimeters/second. The third factor examined the voltage parameter, which was varied between 28 and 33 volts. Each welding condition was conducted randomly, and each condition was tested a total of three times, using full factorial design. The resulting materials were examined using tensile strength and hardness tests and were observed with optical microscopy (OM) and scanning electron microscopy (SEM). The results showed that the welding current, voltage, and travel speed significantly affected the tensile strength and hardness (P value < 0.05). The optimum SAW parameters were 270 amperes, 33 volts, and 10 millimeters/second travel speed. High density and fine pearlite were discovered and resulted in increased material tensile strength and hardness.
Resveratrol Increases Serum BDNF Concentrations and Reduces Vascular Smooth Muscle Cells Contractility via a NOS-3-Independent Mechanism
Authors: Wiciński Michał , Malinowski Bartosz , Węclewicz Mateusz M. , Grześk Elżbieta , Grześk Grzegorz
Published: February 2017

Resveratrol is a polyphenol that presents both antineuroinflammatory properties and the ability to interact with NOS-3, what contributes to vasorelaxation. Brain-derived neurotrophic factor (BNDF), a molecule associated with neuroprotection in many neurodegenerative disorders, is considered as an important element of maintaining stable cerebral blood flow. Vascular smooth muscle cells (VSMCs) are considered to be an important element in the pathogenesis of neurodegeneration and a potential preventative target by agents which reduce the contractility of the vessels. Our main objectives were to define the relationship between serum and long-term oral resveratrol administration in the rat model, as well as to assess the effect of resveratrol on phenylephrine- (PHE-) induced contraction of vascular smooth muscle cells (VSMCs). Moreover, we attempt to define the dependence of contraction mechanisms on endothelial NO synthase. Experiments were performed on Wistar rats (n=17) pretreated with resveratrol (4 weeks; 10 mg/kgp.o.) or placebo. Serum BDNF levels were quantified after 2 and 4 weeks of treatment with ELISA. Contraction force was measured on isolated and perfused tail arteries as the increase of perfusion pressure with a constant flow. Values of serum BNDF in week 0 were1.18±0.12 ng/mL (treated) and1.17±0.13 ng/mL (control) (p= ns). After 2 weeks of treatment, BDNF in the treatment group was higher than in controls,1.52±0.23 ng/mL and1.24±0.13 ng/mL, respectively. (p=0.02) Following 4 weeks of treatment, BDNF values were higher in the resveratrol group compared to control1.64±0.31 ng/mL and1.32±0.26 ng/mL, respectively (p=0.031). EC50values obtained for PHE in resveratrol pretreated arteries were significantly higher than controls (5.33±1.7× 10−7 M/L versus4.53±1.2× 10−8 M/L,p<0.05). These results show a significant increase in BDNF concentration in the resveratrol pretreated group. The reactivity of resistant arteries was significantly reduced for resveratrol pretreated vessels and this effect was partially NOS-3 independent.
Primary Clear Cell Microcystic Adenoma of the Sinonasal Cavity: Pathological or Fortuitous Association?
Authors: Cooper Rosalin , Markham Hannah , Theaker Jeffery , Bateman Adrian , Bunyan David , Sommerlad Matthew , Crawford Gillian , Eccles Diana
Published: February 2017

Primary clear cell microcystic adenoma of the sinonasal cavity is rare. It has previously been described only as a VHL-associated tumour. Von Hippel-Lindau (VHL) syndrome is an inherited cancer syndrome characterised by an elevated risk of neoplasia including clear cell renal cell carcinoma (ccRCC), haemangioblastoma, and phaeochromocytoma. We describe the second reported case of a primary clear cell microcystic adenoma of the sinonasal cavity. The 39-year-old patient with VHL syndrome had previously undergone resection and ablation of ccRCC. He presented with epistaxis. Imaging demonstrated a mass in the ethmoid sinus. Initial clinical suspicion was of metastatic ccRCC. However, tumour morphology and immunoprofile were distinct from the previous ccRCC and supported a diagnosis of primary microcystic adenoma. Analysis of DNA extracted from sinonasal tumour tissue did not show loss of the wild-type allele at the VHL locus. Although this did not support tumour association with VHL disease, it was not possible to look for a loss-of-function mutation. The association of primary microcystic adenoma of the sinonasal cavity with VHL disease remains speculative. These lesions are benign but are likely to require regular surveillance. Such tumours may require repeated surgical excision.
Finite Temperature QCD Sum Rules: A Review
Authors: Ayala Alejandro , Dominguez C. A. , Loewe M.
Published: February 2017

The method of QCD sum rules at finite temperature is reviewed, with emphasis on recent results. These include predictions for the survival of charmonium and bottonium states, at and beyond the critical temperature for deconfinement, as later confirmed by lattice QCD simulations. Also included are determinations in the light-quark vector and axial-vector channels, allowing analysing the Weinberg sum rules and predicting the dimuon spectrum in heavy-ion collisions in the region of the rho-meson. Also, in this sector, the determination of the temperature behaviour of the up-down quark mass, together with the pion decay constant, will be described. Finally, an extension of the QCD sum rule method to incorporate finite baryon chemical potential is reviewed.
The Long-Term Effect of Radical Prostatectomy on Erectile Function, Urinary Continence, and Lower Urinary Tract Symptoms: A Comparison to Age-Matched Healthy Controls
Authors: Mohamad Al-Ali Badereddin , Ponholzer Anton , Augustin Herbert , Madersbacher Stephan , Pummer Karl
Published: February 2017

Introduction. To analyze the impact of radical prostatectomy (RPE) on erectile function and lower urinary tract function in comparison to age-matched healthy men. Materials and Methods. Patients who underwent radical retropubic prostatectomy completed questionnaires containing the IIEF-5, the Bristol female LUTS questionnaire, and the International Prostate Symptom Score (IPSS). Results. Patients after RPE were included (n=363). Age-matched healthy men (n=363) were included. The mean IIEF-5 of patients aged 61–70 yrs after RPE was 10.4±6.6 versus 18.8±5.3 in the control cohort; the respective values for men aged 71–80 yrs after RPE were 7.2±6.5 versus 13.6±7.7 in the control cohort. Urinary incontinence after RPE was reported in 41.9% (61–70 years) and 37.7% (71–80) versus 7.5% and 15.1% in the control cohort. The mean IPSS of patients after RPE aged 61–70 yrs was 5.0±4.4 versus 5.5±4.9 in the control cohort; the respective values for men aged 71–80 yrs were 6.0±4.9 versus 7.5±5.7 in the healthy cohort. Conclusions. The negative effect of radical prostatectomy on erectile and urinary incontinence remains substantial. The physiologically declining erectile and lower urinary tract function with ageing reduces the difference between healthy men and those after surgery. Healthy men have a higher IPSS presumably due to the presence of bladder outlet obstruction.
Fine Tuning Cell Migration by a Disintegrin and Metalloproteinases
Authors: Dreymueller D. , Theodorou K. , Donners M. , Ludwig A.
Published: February 2017

Cell migration is an instrumental process involved in organ development, tissue homeostasis, and various physiological processes and also in numerous pathologies. Both basic cell migration and migration towards chemotactic stimulus consist of changes in cell polarity and cytoskeletal rearrangement, cell detachment from, invasion through, and reattachment to their neighboring cells, and numerous interactions with the extracellular matrix. The different steps of immune cell, tissue cell, or cancer cell migration are tightly coordinated in time and place by growth factors, cytokines/chemokines, adhesion molecules, and receptors for these ligands. This review describes how a disintegrin and metalloproteinases interfere with several steps of cell migration, either by proteolytic cleavage of such molecules or by functions independent of proteolytic activity.
Clinical Application of the PES/WES Index on Natural Teeth: Case Report and Literature Review
Authors: Lanza Alessandro , Di Francesco Fabrizio , De Marco Gennaro , Femiano Felice , Itro Angelo
Published: February 2017

The use of reliable indices to evaluate the aesthetic outcomes in the aesthetic area is an important and objective clinical aid to monitor the results over time. According to the literature various indices were proposed to evaluate aesthetic outcomes of implant-prosthetic rehabilitation of the anterior area like Peri-Implant and Crown Index [PICI], Implant Crown Aesthetic Index [ICAI], Pink Esthetic Score/White Esthetic Score [PES/WES], and Pink Esthetic Score [PES] but none of them was related to prosthetic rehabilitation on natural teeth. The aim of this study is to verify the validity of PES/WES index for natural tooth-prosthetic rehabilitation of the anterior area. As secondary objective, we proposed to evaluate the long-term predictability of this clinical application, one of which is presented below, following the analysis of the most currently accepted literature.
Tomographic Aspects of Advanced Active Pulmonary Tuberculosis and Evaluation of Sequelae following Treatment
Authors: Capone Rafael Barcelos , Capone Domenico , Mafort Thiago , Mogami Roberto , Rodrigues Rosana de Souza , Menna Barreto Miriam , Rufino Rogerio
Published: February 2017

Objectives.To evaluate tomographic changes in pulmonary tuberculosis (TB), degree of agreement among three radiologists regarding tomographic diagnoses, and sequelae following treatment.Methods.Cross-sectional and descriptive study of 74 TB patients confirmed by sputum culture and chest computed tomography before (CT1) and 6 months after (CT2) drug therapy. Results were performed by three radiologists blinded to clinical and laboratory results.Results.Main findings in CT1 included nodules indicating the presence of a tree-in-bud pattern in 93% of cases, ill-defined nodules in 84% of cases, consolidation in 77% of cases, architectural distortion in 71% of cases, cavitary lesions in 62% of cases, and ground glass opacities in 37% of cases. Airway involvement, characterized by increased thickness and dilatation of the bronchial walls, occurred in 93% of cases. Pleural involvement occurred in 54%. There was an agreement on active TB among the three radiologists in 85% of cases. The results in CT2 indicated the presence of architectural distortion in 91% of cases and cylindrical bronchiectasis in 86%.Conclusions.The study established a tomographic pattern for diagnosis of active TB characterized by the presence of airway nodules, consolidation, architectural distortion, and cavitary lesions, and an almost complete degree of agreement (Kappa) was observed among the radiologists (0.85). CT after treatment assists in defining the cure.
D/Ecrire une ville: Géocritique de Nouméa à partir de brèches romanesques
Authors: Banaré Eddy
Published: February 2017

This article explores the way literature informs and is informed by the perception of urban postcolonial space. Chroniques De La Mauvaise Herbe, the first novel of Vincent Vuibert (2013), marks a new threshold in the Francophone oceanian literary field, at first by the influences claimed by the author and then by the representation renewed of Noumea. Among these influences is the contemporary U.S. thriller in which Vuibert renews an aesthetics of the marginality to stack them in the colonial and postcolonial segmentarities. His characters seem to evolve along borders established from regimes of political, historic and economic powers, which they undergo or also try to thwart. On the other hand, this novel joins in a discursive tradition centred on the city inaugurated by the first Kanak political militancy of the 1970s and which was strengthened in the literary field with the signature of the political agreements of 1988 and 1998. It is a question here of showing how the novel draws routes in Noumea who are so many ways to describe oppositions and encounters.
Diagnosis of sphingolipidoses: a new simultaneous measurement of lysosphingolipids by LC-MS/MS
Authors: Polo Giulia , Burlina Alessandro P. , Kolamunnage Thilini B. , Zampieri Michele , Dionisi-Vici Carlo , Strisciuglio Pietro , Zaninotto Martina , Plebani Mario , Burlina Alberto B.
Published: February 2017

Background:

Lysosphingolipids (LysoSLs) are derivatives of sphingolipids which have lost the amide-linked acyl chain. More recently, LysoSLs have been identified as storage compounds in several sphingolipidoses, including Gaucher, Fabry and Niemann-Pick diseases. To date, different methods have been developed to measure each individual lysosphingolipid in plasma. This report describes a rapid liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) assay for simultaneous quantification of several LysoSLs in plasma.

Methods:

We analyzed the following compounds: hexosylsphingosine (HexSph), globotriaosylsphingosine (LysoGb3), lysosphingomyelin (LysoSM) and lysosphingomyelin-509 (LysoSM-509). The sample preparation requires only 100 μL of plasma and consists of an extraction with a mixture of MeOH/acetone/H

Results:

The method validation showed high sensitivity, an excellent accuracy and precision. Reference ranges were determined in healthy adult and pediatric population. The results demonstrate that the LC-MS/MS method can quantify different LysoSLs and can be used to identify patients with Fabry (LysoGb3), Gaucher and Krabbe (HexSph) diseases, prosaposine deficiency (LysoGb3 and HexSph), and Niemann-Pick disease types A/B and C (LysoSM and LysoSM-509).

Conclusions:

This LC-MS/MS method allows a rapid and simultaneous quantification of LysoSLs and is useful as a biochemical diagnostic tool for sphingolipidoses.
Logarithmic Sobolev inequalities for Moebius measures on spheres
Authors: Barthe Franck , Ma Yutao , Zhang Zhengliang
Published: February 2017

In this paper, using the method in [1], i.e., reduce Moebius measures

μ
x
n

{\mu_{x}^{n}}

indexed by

|
x
|

<
1

{|x|<1}

on spheres

S

n
-
1

{S^{n-1}}

(

n
≥
3

{n\geq 3}

) to one-dimensional diffusions on

[
0
,
π
]

{[0,\pi]}

, we obtain that the optimal Poincaré constant is not greater than

2

n
-
2

{\frac{2}{n-2}}

and the optimal logarithmic Sobolev constant denoted by

C
LS

⁢

(

μ
x
n

)

{C_{\rm LS}(\mu_{x}^{n})}

behaves like

1
n

⁢

log
⁡

(

1
+

1

1
-

|
x
|

)

{\frac{1}{n}\log(1+\frac{1}{1{-}|x|})}

. As a consequence, we claim that logarithmic Sobolev inequalities are strictly stronger than

L
2

{L^{2}}

-transportation-information inequalities.
A Compact Pentagonal Ring CPW-Fed Zeroth Order Resonating Antenna with Gain Enhancement
Authors: Gupta Ashish , Chaudhary Raghvendra Kumar
Published: February 2017

In this work, a pentagonal ring CPW-fed zeroth order resonating (ZOR) antenna with gain enhancement is proposed. Gain enhancement is achieved by means of electromagnetic bandgap structures (EBG) loaded on patch. The proposed antenna is operated in series resonant mode, therefore resonance frequency is dominated by series parameters of the conventional CRLH transmission line. The antenna comprises of a circular patch which is imposed by interdigital capacitor and EBG structures. Meandered line inductor is connected between patch and pentagonal ground plane in order to ensure miniaturization using CRLH resonant approach. Measurement results shows that proposed antenna offers ZOR resonance at 2.7 GHz with 4.81 %, 10 dB fractional bandwidth. The antenna offers simulated gain of 1.63 dBi and 80.6 % radiation efficiency at ZOR frequency. Surface current distribution shows that how these CRLH – TL components responsible for origination of ZOR mode. Proposed antenna exhibits excellent radiation patterns with cross polarization level of −53 dB in the boresight direction.
Changes in Export Affinity after the Creation of the EMU
Authors: Halevi Nadav
Published: February 2017

Abstract:

The creation of the EMU in 1999 gave its original eleven members additional advantages for intra-EMU trade, relative to other members of the EU and the rest of the world. Other things being equal, this should have resulted in greater export affinity within the Euro Zone. This paper constructs export affinity indices for the intra-regional exports of the EMU, for its exports to the then other members of the EU, and to the countries that joined the EU during this period, for 1997, a full year before the Euro, and for 2007. These are used to see whether the net effect on export affinity are as expected, or whether other forces affecting the growth and direction of world exports led to different results. It was found that though there was clear export affinity within the EMU in both years examined, and, of course, tremendous growth in total exports to all regions, export affinity fell rather than rose between the two years. As far as special affinity is concerned, other factors affecting the development of world exports cancelled the advantages both of EMU membership and of new membership in the EU. Similar net results were found for bi-lateral export affinity indices of the original EMU members.
Exchange Rate Adjustments and US Trade with China: What does a State Level Analysis Tell Us?
Authors: Demir Firat , Wu Chen
Published: February 2017

In this paper we explore the trade effects of bilateral real exchange rate changes between the 50 US states and China over the period of 2005–2012. The empirical results based on state-level trade flows and state-level relative prices suggest that the long-run real exchange rates elasticity of US exports to China is in the range of [–3.77, –2.85] and that of Chinese exports to the US is in the range of [–0.23, –3.34]. We also find that state-level differences in human capital and financial development are significant determinants of their export performances with respect to China. Based on the most optimistic scenario, our results suggest that the RMB needs to further appreciate against the dollar by at least 1.8 percent a year for 16 years for the US to achieve balanced trade with China.
Comparison results for solutions of elliptic Neumann problems with lower-order terms via Steiner symmetrization
Authors: Li Fengquan , Li Wenbo
Published: February 2017

In this paper, we consider a Neumann problem for a linear elliptic equation with lower-order terms. A comparison result for solutions of the problem is proved by using Steiner symmetrization.
The Effect of Acidity Coefficient on Crystallization Behavior of Blast Furnace Slag Fibers
Authors: Tian Tie-Lei , Zhang Yu-Zhu , Xing Hong-wei , Li Jie , Zhang Zun-Qian
Published: February 2017

The chemical structure of mineral wool fiber was investigated by using Fourier Transform Infrared Spectroscopy (FTIR). Next, the glass transition temperature and the crystallization temperature of the fibers were studied. Finally, the crystallization kinetics of fiber was studied. The results show that the chemical bond structure of fibers gets more random with the increase of acidity coefficient. The crystallization phases of the fibers are mainly melilites, and also a few anorthites and diopsides. The growth mechanism of the crystals is three dimensional. The fibers with acidity coefficient of 1.2 exhibit the best thermal stability and is hard to crystallize as it has the maximum aviation energy of crystallization kinetics.
Improving epidemic size prediction through stable reconstruction of disease parameters by reduced iteratively regularized Gauss–Newton algorithm
Authors: Smirnova Alexandra , Chowell-Puente Gerardo , deCamp Linda , Moghadas Seyed , Sheppard Michael Jameson
Published: February 2017

Classical compartmental epidemic models of infectious diseases track the dynamic transition of individuals between different epidemiological states or risk groups. Reliable quantification of various transmission pathways in these models is paramount for optimal resource allocation and successful design of public health intervention programs. However, with limited epidemiological data available in the case of an emerging disease, simple phenomenological models based on a smaller number of parameters can play an important role in our quest to make forward projections of possible outbreak scenarios. In this paper, we employ the generalized Richards model for stable numerical estimation of the epidemic size (defined as the total number of infections throughout the epidemic) and its turning point using case incidence data of the early epidemic growth phase. The minimization is carried out by what we call the Reduced Iteratively Regularized Gauss–Newton (RIRGN) algorithm, a problem-oriented numerical scheme that takes full advantage of the specific structure of the non-linear operator at hand. The convergence analysis of the RIRGN method is suggested and numerical simulations are conducted with real case incidence data for the 2014–15 Ebola epidemic in West Africa. We show that the proposed RIRGN provides a stable algorithm for early estimation of turning points using simple phenomenological models with limited data.
Mathematical and numerical modeling of plate dynamics with rotational inertia
Authors: Bonaldi Francesco , Geymonat Giuseppe , Krasucki Françoise , Vidrascu Marina
Published: February 2017

We give a presentation of the mathematical and numerical treatment of plate dynamics problems including rotational inertia. The presence of rotational inertia in the equation of motion makes the study of such problems interesting. We employ HCT finite elements for space discretization and the Newmark method for time discretization in FreeFEM++, and test such methods in some significant cases: a circular plate clamped all over its lateral surface, a rectangular plate simply supported all over its lateral surface, and anL-shaped clamped plate.
Multi-fetal pregnancy reduction (MFPR) to twins or singleton – medical justification and ethical slippery slope
Authors: Drugan Arie , Weissman Amir
Published: February 2017

Multi-fetal pregnancy reduction (MFPR) is an ethically acceptable procedure aimed to increase survival and well-being of the remaining fetuses from high-order multiple gestations. In most cases we offer the procedure to triplets or quadruplets and opt to preserve twins; lately, the option to maintain a single fetus was suggested. We examined the outcomes of 140 pregnancies that underwent MFPR in our center and were followed to delivery – 105 were reduced to twins and 35 to singletons. The rate of procedure-related pregnancy loss was identical (2.9%). Leaving only one fetus was associated with a higher gestational age at delivery (35.4±2.4 weeks vs. 37.7±2.1 weeks, P<0.0001), with heavier neonates (2222 g vs. 3017 g, P<0.0001) and with a reduction in the cesarean section (CS) rate (76% in twins vs. 51.4% in singletons, P=0.02). Six pregnancies reduced to twins (5.8%) ended before 32 weeks as compared to one pregnancy reduced to a singleton. We conclude that reduction of triplets to singletons is medically and ethically acceptable, after thorough counseling of patients. However, considering the pregnancy loss risk of MFPR and the relatively good outcome of twin gestations, reduction of twins to singletons is ethically acceptable only in extraordinary maternal or fetal conditions.
Anti-inflammatory Elafin in human fetal membranes
Authors: Stalberg Cecilia , Noda Nathalia , Polettini Jossimara , Jacobsson Bo , Menon Ramkumar
Published: February 2017

Objective:

Elafin is a low molecular weight protein with antileukoproteinase, anti-inflammatory, antibacterial and immunomodulating properties. The profile of Elafin in fetal membranes is not well characterized. This study determined the changes in Elafin expression and concentration in human fetal membrane from patients with preterm prelabor rupture of membranes (PPROM) and

Method:

Elafin messenger RNA (mRNA) expressions were studied in fetal membranes from PPROM, normal term as well as in normal term not in labor membranes in an organ explant system treated (24 h) with lipopolysaccharide (LPS), using quantitative reverse transcription-polymerase chain reaction (RT-PCR). Enzyme-linked immunosorbent assay (ELISA) measured Elafin concentrations in culture supernatants from tissues treated with LPS and polybacterial combinations of heat-inactivated

Results:

Elafin mRNA expression in fetal membranes from women with PPROM was significantly higher compared to women who delivered at term after normal pregnancy (5.09±3.50 vs. 11.71±2.21; P<0.05).

Conclusion:

Higher Elafin expression in PPROM fetal membranes suggests a host response to an inflammatory pathology. However, lack of Elafin response to LPS and polymicrobial treatment is indicative of the minimal anti-inflammatory impact of this molecule in fetal membranes.
Deriving Rain Threshold for Early Warning Based on a Coupled Hydrological-Hydraulic Model
Authors: Ivanescu Veronica , Drobot Radu
Published: February 2017

Flash floods are highly variable phenomena in both time and space. Therefore, tools with the potential to provide early warning are needed to analyse them. In Europe, flash floods often occur on small catchments; it has already been shown that the spatial variability of rainfall has a great impact on the catchment response. The aim of this paper is to use a coupled hydrological-hydraulic model (MIKE SHE/MIKE 11) to determine the rainfall thresholds and transformation coefficients from hourly rain to other durations, which will lead to flooding of the inhabited areas to the ungauged Ungureni catchment. The model was calibrated and validated using a reference discharge previously obtained by UTCB at the downstream gauge section of Teleorman River (Tatarastii de Sus) using MIKE 11 UHM module. Once the rainfall thresholds are determined, they can be used in flood forecasting and issuing warning with lead time for the inhabitants of the two villages located in Ungureni watershed. The method proposed in this paper can be used for other watersheds prone to flooding, so warnings can be issued with lead time.
Images Encryption Method using Steganographic LSB Method, AES and RSA algorithm
Authors: Moumen Abdelkader , Sissaoui Hocine
Published: February 2017

Vulnerability of communication of digital images is an extremely important issue nowadays, particularly when the images are communicated through insecure channels. To improve communication security, many cryptosystems have been presented in the image encryption literature. This paper proposes a novel image encryption technique based on an algorithm that is faster than current methods. The proposed algorithm eliminates the step in which the secrete key is shared during the encryption process. It is formulated based on the symmetric encryption, asymmetric encryption and steganography theories. The image is encrypted using a symmetric algorithm, then, the secret key is encrypted by means of an asymmetrical algorithm and it is hidden in the ciphered image using a least significant bits steganographic scheme. The analysis results show that while enjoying the faster computation, our method performs close to optimal in terms of accuracy.
Solution of Fifth-order Korteweg and de Vries Equation by Homotopy perturbation Transform Method using He’s Polynomial
Authors: Sharma Dinkar , Singh Prince , Chauhan Shubha
Published: February 2017

In this paper, a combined form of the Laplace transform method with the homotopy perturbation method is applied to solve nonlinear fifth order Korteweg de Vries (KdV) equations. The method is known as homotopy perturbation transform method (HPTM). The nonlinear terms can be easily handled by the use of He’s polynomials. Two test examples are considered to illustrate the present scheme. Further the results are compared with Homotopy perturbation method (HPM).
Optimization of the prediction of second refined wavelet coefficients in electron structure calculations
Authors: Sziová Brigita , Nagy Szilvia , Pipek János
Published: February 2017

In wavelet-based solution of eigenvalue-type differential equations, like the Schrödinger equation, refinement in the resolution of the solution is a costly task, as the number of the potential coefficients in the wavelet expansion of the solution increases exponentially with the resolution.

Predicting the magnitude of the next resolution level coefficients from an already existing solution in an economic way helps to either refine the solution,or to select the coefficients, which are to be included into the next resolution level calculations, or to estimate the magnitude of the error of the solution. However, after accepting a solution with a predicted refinement as a basis, the error can still be estimated by a second prediction, i.e., from a prediction to the second finer resolution level coefficients. These secondary predicted coefficients are proven to be oscillating around the values of the wavelet expansion coefficients of the exact solution. The optimal averaging of these coefficients is presented in the following paper using a sliding average with three optimized coefficients for simple, one-dimensional electron structures.
Variable Viscosity Effects on Time Dependent Magnetic Nanofluid Flow past a Stretchable Rotating Plate
Authors: Ram Paras , Joshi Vimal Kumar , Sharma Kushal , Walia Mittu , Yadav Nisha
Published: February 2017

An attempt has been made to describe the effects of geothermal viscosity with viscous dissipation on the three dimensional time dependent boundary layer flow of magnetic nanofluids due to a stretchable rotating plate in the presence of a porous medium. The modelled governing time dependent equations are transformed a from boundary value problem to an initial value problem, and thereafter solved by a fourth order Runge-Kutta method in MATLAB with a shooting technique for the initial guess. The influences of mixed temperature, depth dependent viscosity, and the rotation strength parameter on the flow field and temperature field generated on the plate surface are investigated. The derived results show direct impact in the problems of heat transfer in high speed computer disks (Herrero et al. [1]) and turbine rotor systems (Owen and Rogers [2]).
Numerical heat transfer analysis of transcritical hydrocarbon fuel flow in a tube partially filled with porous media
Authors: Jiang Yuguang , Feng Yu , Zhang Silong , Qin Jiang , Bao Wen
Published: February 2017

Hydrocarbon fuel has been widely used in air-breathing scramjets and liquid rocket engines as coolant and propellant. However, possible heat transfer deterioration and threats from local high heat flux area in scramjet make heat transfer enhancement essential. In this work, 2-D steady numerical simulation was carried out to study different schemes of heat transfer enhancement based on a partially filled porous media in a tube. Both boundary and central layouts were analyzed and effects of gradient porous media were also compared. The results show that heat transfer in the transcritical area is enhanced at least 3 times with the current configuration compared to the clear tube. Besides, the proper use of gradient porous media also enhances the heat transfer compared to homogenous porous media, which could help to avoid possible over-temperature in the thermal protection.
On the solutions of electrohydrodynamic flow with fractional differential equations by reproducing kernel method
Authors: Akgül Ali , Baleanu Dumitru , Inc Mustafa , Tchier Fairouz
Published: February 2017

In this manuscript we investigate electrodynamic flow. For several values of the intimate parameters we proved that the approximate solution depends on a reproducing kernel model. Obtained results prove that the reproducing kernel method (RKM) is very effective. We obtain good results without any transformation or discretization. Numerical experiments on test examples show that our proposed schemes are of high accuracy and strongly support the theoretical results.
ISS-N1 makes the first FDA-approved drug for spinal muscular atrophy
Authors: Ottesen Eric W.
Published: February 2017

Spinal muscular atrophy (SMA) is one of the leading genetic diseases of children and infants. SMA is caused by deletions or mutations of Survival Motor Neuron 1 (SMN1) gene. SMN2, a nearly identical copy of SMN1, cannot compensate for the loss of SMN1 due to predominant skipping of exon 7. While various regulatory elements that modulate SMN2 exon 7 splicing have been proposed, intronic splicing silencer N1 (ISS-N1) has emerged as the most promising target thus far for antisense oligonucleotide-mediated splicing correction in SMA. Upon procuring exclusive license from the University of Massachussets Medical School in 2010, Ionis Pharmaceuticals (formerly ISIS Pharamaceuticals) began clinical development of Spinraza™ (synonyms: Nusinersen, IONIS-SMNRX, ISIS-SMNRX), an antisense drug based on ISS-N1 target. Spinraza™ showed very promising results at all steps of the clinical development and was approved by US Food and Drug Administration (FDA) on December 23, 2016. Spinraza™ is the first FDA-approved treatment for SMA and the first antisense drug to restore expression of a fully functional protein via splicing correction. The success of Spinraza™ underscores the potential of intronic sequences as promising therapeutic targets and sets the stage for further improvement of antisense drugs based on advanced oligonucleotide chemistries and delivery protocols.
Effects of Hypericum perforatum extract on oxaliplatin-induced neurotoxicity: in vitro evaluations
Authors: Cinci Lorenzo , Di Cesare Mannelli Lorenzo , Maidecchi Anna , Mattoli Luisa , Ghelardini Carla
Published: February 2017

Hypericum perforatum L. has been used for centuries as a natural remedy for the treatment of many disorders. Neuropathic pain is a common side effect of oxaliplatin-based chemotherapy and often the cause of therapy discontinuation. Thanks to its anti-inflammatory and analgesic effects, the use of H. perforatum may be a novel therapeutic strategy for neuropathy. The aim of this paper was to evaluate the effect of H. perforatum hydrophilic extract on an in vitro model of oxaliplatin-induced neurotoxicity. The antioxidant potential of extract was first evaluated in cell-free models by the thiobarbituric acid-reactive substances assay and nitro blue tetrazolium oxidation test; the ability of H. perforatum extract to reduce oxaliplatin-induced caspase-3 activity in rat astrocytes and its potential interference with the cytotoxic effects of oxaliplatin in a colorectal cancer in vitro model (HT-29 cells) were also evaluated. The extract showed a significant antioxidant effect and was able to reduce caspase-3 activity in rat astrocytes. Of note, the extract alone exerted a cytotoxic effect in HT-29 cells and did not reduce the cytotoxicity of oxaliplatin in HT-29 cells. These data suggest that H. perforatum could be used as a novel therapeutic strategy for counteracting chemotherapy-induced neuropathy.
Estimation of the Inhibition Efficiency of Polysorbate 80 Against the Corrosion of 6061 Aluminum Alloy in Di-Sodium Hydrogen Orthophosphate Solution
Authors: Abd El-Rehim S. S. , Deyab M. A. , Hassan H. H. , Shaltot Amr M.
Published: February 2017

The inhibiting behavior of polysorbate 80 on 6061 aluminum alloy corrosion was evaluated in 1.0 M Na2HPO4solution. Potentiodynamic polarization and electrochemical impedance spectroscopy (EIS) techniques were used in this study. The obtained results showed that the inhibition efficiency increases by increasing the concentration of polysorbate 80 reaching 85.8% at 500 ppm. Good agreement was found between the results obtained from the two techniques used. The inhibition process was found to be due to adsorption of the organic compound on the alloy surface obeying the Langmuir isotherm. Polarization curves indicate that the inhibition of polysorbate 80 has the mixed anodic–cathodic nature. EIS exhibits one capacitive loop which is attributed to the double layer charging and the charge transfer process. The inhibition efficiency of polysorbate 80 decreased by rising the temperature in the range of 303–333 K. These results confirm the physisorption of the inhibitor molecules on the metal surface. The thermodynamic functions for the dissolution and adsorption processes were calculated and discussed.
Tratamentos não farmacológicos que melhoram a qualidade de vida de idosos com doença de Alzheimer: uma revisão sistemática
Authors: Carvalho Paula Danielle Palheta ,   Universidade Federal do Pará, Brasil, Magalhães Celina Maria Colino , Pedroso Janari da Silva
Published: February 2017

RESUMO Objetivo Realizar uma revisão sistemática sobre quais são os tratamentos não farmacológicos que ajudam a melhorar a qualidade de vida (QV) de idosos com doença de Alzheimer (DA) mais descritos na literatura nos últimos dez anos (2006-2016). Métodos Revisão sistemática da literatura realizada nas três primeiras semanas de janeiro de 2016, nas bases: Capes, SciELO, Web of Science, PubMed, Lilacs e Scopus. Foram utilizadas duas combinações de termos: (1) predictors AND quality of life AND elderly AND Alzheimer’s disease e (2) non-pharmacological treatment AND quality of life AND Alzheimer’s disease. Foram encontrados 240 artigos e analisados o título e o resumo dos artigos e, quando necessário, o próprio texto. Do total de 240 artigos, apenas quatro trabalhos preencheram os critérios de inclusão e foram selecionados. Resultados Os resultados mostraram que os tratamentos não farmacológicos mais descritos, no referido período, visando melhorar a QV de idosos com DA, foi a reabilitação, tanto cognitiva quanto multidisciplinar. Conclusão As técnicas de reabilitação mostraram-se capazes de melhorar a QV de idosos com doença de Alzheimer leve.
QUALITY INDEX AND HARVEST MATURITY OF Eugenia cibrata FRUITS
Authors: DINIZ GUIOMAR ALMEIDA SOUSA , ARAÚJO NETO SEBASTIÃO ELVIRO DE , NOVALLI DHEIMY DA SILVA , NOGUEIRA NOHELENE THANDARA , SILVA IRENE FERRO DA
Published: February 2017

ABSTRACT The aim of this study was to characterize and determine the quality index and the harvest maturity of Eugenia cibrata fruits. Fruits were harvested at 39, 41 and 43 days after sprouting and selected by the larger size. Fruits ripened on the plant until complete abscissions were considered standard for determining the quality index after harvest. Samples were analyzed at harvest day and at two days of storage at temperature of 26 ± 2 ° C and relative humidity of 85-90%. The following items were evaluated: firmness, number of seeds, longitudinal and transversal diameter, shape index, weight of seeds, pulp and fruit, titratable acidity (TA ), soluble solids (SS), ascorbic acid, TA / SS ratio and pulp yield. The experimental design was completely randomized in a split plot scheme in time, with additional treatment. E. cibrata fruit is a round berry with 0.98 shape index; mass of 24.28 g, green epicarp and white endocarp. The maturity stage identified as ideal for harvest occurred from 43 days after flower opening (anthesis). Fruits selected among those with larger sizes also reached physiological maturity and quality similar to those ripened on the plant. The quality index of E. cibrata is pH 2.88; soluble solids of 3.7%; titratable acidity of 3.38% in citric acid; ascorbic acid of 77.05 mg 100g-1, TA / SS ratio of 1.09 and pulp yield of 72.01%.
NIETZSCHE E O TRANS-HUMANISMO: EM TORNO DA QUESTÃO DA AUTOSSUPERAÇÃO DO HOMEM
Authors: Oliveira Jelson Roberto de ,   PUC,  Brazil
Published: February 2017

RESUMO O presente artigo pretende analisar a relação entre o pensamento de Nietzsche e o movimento trans-humanista, cuja força teórica alargou-se durante as primeiras décadas do novo milênio, amparada na crescente história de êxitos da biotecnologia. Pretende-se apresentar uma posição crítica à apropriação que o trans-humanismo vem fazendo do pensamento do autor de "Assim falou Zaratustra". O foco da análise é o programa de autossuperação do homem, que será analisado a partir de três eixos centrais: a ideia de natureza e de liberdade; o problema dos valores; e a questão do aperfeiçoamento promovido pela bioengenharia e suas consequências para o destino do homem. Presume-se, assim, não dar conta da amplitude e complexidade da temática, mas oferecer pistas para enfrentar a questão sob o viés da relação de continuidade entre o niilismo e a técnica contemporânea, nesse caso, do ponto de vista antropológico.