bluuebunny/crossref_metadata_2025 huggingface dataset:
IMPACT OF COVID-19 PANDEMIC ON MICRO, SMALL AND MEDIUM SCALE INDUSTRIES IN INDIA
Authors:   Asst. Prof., Prerna College of Commerce, Nagpur, Maharashtra., Jaikar Sheetal
Published: June 2022

Among other sectors the Industrial sector has not been any exception during the pandemic that shook the entire world.In India especially the fourth cadre people of Industries i.e the laborers faced the harsh situations in their life to even survive without employment.Many sectors along with the business sector where Medium and small scale Industries faced a very crucial times during the lock-down that was imposed in India where remarkable changes were seen in almost every employees life.Many of the laborers were compelled to leave the job and migrate to their hometown as there was a layoff in their Enterprises and some were even closed or are on the verge of closure due to no production and money crunch as well.This Research paper encompass those parameters on the bases of which the Small and Medium scale Industries were running short of finance or were temporarily closed. Studies and surveys shows that approximately 95% firms were impacted negatively due to national lockdown imposed in April 2020, 70% of businesses remained disrupted till August 2020. Even after progressive unlocking, reports suggest that almost 40% businesses remained interrupted till the end of February 2021.
A SURVEY REPORT ON PROJECTOMATE
Authors:   Assistant Professor, Department Of Computer Application, Prerna College Of Commerce, Nagpur., Pathak Manjiri
Published: June 2022

The Agile Development approach to systems development is the new fundamental for developers. Twelve Principles supporting the Agile Manifesto were elaborated in support. Hence the team always has to look towards identifying and proposing appropriate reference disciplines which are manifest in the Agile Development Universe of Discourse. The Manifesto evokes some reference disciplines to support its various aspects. Why is it desirable and necessary to search for such reference disciplines? The answer is Alternative Software Development and Project Management approaches, such as Software Prototyping and Rapid Development and now including Agile Development, all seemed based on pragmatic experience and have been designed mostly by consultants and practitioners. While this is not in any way to denigrate or deprecate them, it is felt that support for these approaches needs to also come from other disciplines, such as management studies, leadership studies, and the like to give Agile Development a more solid theoretical and intellectual basis.
COMPARATIVE EVALUATION OF REMINERALIZATION POTENTIAL OF SODIUM FLUORIDE VARNISH AND SODIUM FLUORIDE VARNISH FORTIFIED WITH BIOGLASS -AN IN VITRO STUDY
Authors:   Postgraduate Student, Department of Pediatric and Preventive Dentistry AJ Institute of Dental Sciences Karnataka., M.S Shreya , a Barkathunnisa ,   Postgraduate Student, Department of Pediatric and Preventive Dentistry AJ Institute of Dental Sciences Karnataka., b Anusha ,   Professor and Head Professor and Head, Department of Pediatric and Preventive Dentistry, AJ Institute of Dental Sciences Karnataka., a Krithikashetty ,   Postgraduate Student, Department of Pediatric and Preventive Dentistry AJ Institute of Dental Sciences Karnataka., Krishnan E. Anandhu ,   Postgraduate Student, Department of Pediatric and Preventive Dentistry AJ Institute of Dental Sciences Karnataka., Raj Kiran ,   Professor and Head Professor and Head, Department of Pediatric and Preventive Dentistry, AJ Institute of Dental Sciences Karnataka., B. Sowmya ,   Professor and Head Professor and Head, Department of Pediatric and Preventive Dentistry, AJ Institute of Dental Sciences Karnataka., Kumar Sarath ,   Post Graduate Student, Department of Pediatric and Preventive Dentistry, Divya Jyoti College of Dental.
Published: June 2022

Aim:- The present study is aimed to compare and evaluate the remineralization potential of Sodium fluoride varnish alone and sodium fluoride varnish fortified with bioglass Material And Method:- caries like lesions were produced and surface microhardness was evaluated. The specimens were then divided into 2 groups with 36 teeth in each group, accordingly remineralization treatment was employed. 36 teeth were treated with sodium fluoride varnish (duraphat) (group 1) and 36 teeth with treated with sodium fluoride fortified with bioglass (Fluro dip bioactive) (group 2). During the next 10 days, the samples were subjected to a pH-cycling system, which simulated the intraoral conditions, surface microhardnesstesting was performed on the 11th day to evaluate remineralization. The values obtained were tabulated and statistically analyzed using one-way ANOVA. Result:- Significant remineralization was seen with sodium fluoride fortified with bioglass followed by sodium fluoride varnish. Conclusion:- The results of the study concluded that sodium fluoride varnish fortified with bioglass has better remineralizing potential than Sodium fluoride varnish alone and can be used to reduce caries advancements at the stage of early carious lesions.
INFLUENCE DES PLANTATIONS MONOSPECIFIQUES DESSENCES FORESTIERES SUR LA DIVERSITE ET LABONDANCE DE LA FAUNE ENTOMOLOGIQUE ASSOCIEE AUX LEGUMINEUSES SAUVAGES DUNE ZONE PROTEGEE AU SENEGAL (BANDIA)
Authors:   Equipe de Genetique et de Gestion des Populations, Departement de Biologie Animale, Universite Cheikh Anta Diop de Dakar, Faculte des Sciences et Techniques, Dakar, Senegal., Omar Diane , Ibrahima Kane ,   Faculte des Sciences et Technologies de lEducation et de la Formation., Diombo Thiang ,   Equipe de Genetique et de Gestion des Populations, Departement de Biologie Animale, Universite Cheikh Anta Diop de Dakar, Faculte des Sciences et Techniques, Dakar, Senegal., Toffene Diome ,   Equipe de Genetique et de Gestion des Populations, Departement de Biologie Animale, Universite Cheikh Anta Diop de Dakar, Faculte des Sciences et Techniques, Dakar, Senegal., Pape Mbacke Sembene ,   Equipe de Genetique et de Gestion des Populations, Departement de Biologie Animale, Universite Cheikh Anta Diop de Dakar, Faculte des Sciences et Techniques, Dakar, Senegal.
Published: June 2022

Une etude, portant sur linfluence du couvert ligneux monospecifique dessences forestieres sur la diversite et labondance des insectes infeodes aux gousses de legumineuses sauvages, a ete menee dans la station ISRA de la reserve de Bandia, de juin a octobre 2021. Cette etude a ete entreprise pour contribuer a la connaissance des insectes infeodes aux gousses de legumineuses sauvages. Sur 15 especes de legumineuses sauvages, nous avons recense 189 specimens dinsectes appartenant a trois ordres : Ordre des Coleoptera (65,605%) avec six especes Callosobruchus maculatus (44,44%), Caryedon gonagra (7,94 %), Caryedon serratus (4,76%), Carpophilus fumatus (3,71), Caryedon sp. (3,18%),Bruchus rufimanus (1,59%) Ordre des Hemiptera avec une espece non identifiee et lOrdre des Lepidoptera avec une espece, en loccurrence Ephestia cautella avec une prevalence de 33,62%. Notre etude a montre une bonne diversite des especes dans le milieu et que la plantation monospecifique dessences forestieres, exotiques et autochtones, augmente leur diversite et leur abondance. Nos resultats revelent cependant que les populations de phytophages sont caracterisees par une dynamique adaptative et une coevolution en fonction de la disponibilite des plantes hÃ´tes. Ce genre detudes est mene pour la premiere fois au Senegal.
ROLE OF CHEST COMPUTED TOMOGRAPHY IN EVALUATION AND MANAGEMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
Authors: Sharma Rachit , Prasad Rajendra , Maheshwari Deepak , Kakkar Rishabh , Manchanda Jay
Published: June 2022

Chronic obstructive pulmonary disease (COPD) exhibits signiï¬cant heterogeneity in its clinical presentation and rate of disease progression among affected individuals, owing at least in part to differing pulmonary morphologic abnormalities. Symptom assessment, spirometric evaluation, and frequency of respiratory exacerbations have traditionally been used to determine disease severity and guide management. ChestComputed Tomography (CT) scanning provides clear and exact in vivo assessments of organs, and from these data, we can extract subjective and objective features such as parenchymal remodeling, airway dilatation, and vascular calciï¬cation. These features can be used to detect the extent of the disease, its severity and also predict its clinical course. However, despite the increasing use and widespread availability of chest CT scans, the wealth of information from Chest CT scans is not consistently used in routine practice and has not yet been incorporated into clinical guidelines for COPD diagnosis, management or prognosis.This article reviews the role of CT in differentiating different phenotypes of Chronic Obstructive Pulmonary Disease (COPD), its clinical implications of emphysema, airway disease, air trapping, and pulmonary vasculature and, highlight the potential value of assessing nonpulmonary structures such as coronary arteries and vertebral bone to provide better comprehensive care for patients with COPD.
ACADEMIC TASK COMMITMENT AND ACADEMIC ACHIEVEMENT THE INTER CHARACTERISTICS OF ACADEMIC OUTCOMES
Authors:   Theres a difference between interest and commitment. When youre interested in doing something, you do it only when circumstances permit. When youre committed to something, you accept no excuses, only results. - Art Turock., Surendar G.
Published: June 2022

This research paper is an attempt to understandcommitment and achievement which are very important in predicting individual and group success in any endeavor. Research has shown that commitment invariably has a major impact on behavioral outcomes connected to task performance. Task performance leads to achievement which has a very crucial impact on personality factorslike self-esteem, self-concept, emotional intelligence and other connected constructs. Environmental and social factors are also the contributing factors in commitment-achievement interplay.This paper studies academic task commitment vis-a-vis academic performance/achievement of high school students of select schools of Bangalore-India, belonging to three different boardsnamely Central Board of Secondary Education , Indian Council of Secondary Education and Karnataka State Board, each havingunique syllabus and board of examination. Gender and socio economic factors have been considered in the study. The results reveal the rejection of the null hypothesis which states that there was no significant relationship between Academic Task commitment and Academic Achievement among school children. The study also found that there was no significant difference in Academic Task Commitment among boys and girls due to gender. Further, the study found that there was no significant difference in Academic Achievement amongboys and girls due to gender. Finally, the null hypothesis which states that socio economic status difference has no significance in Academic Task Commitment among school children is accepted.Data analysis throws significant light and possible interplay between constructs that can be factored for designing very significant interventions with more detailed study on implications.
MATERNAL MORBIDITY: INVENTORY FEASIBILITY AND ACCEPTABILITY OF MEASUREMENT TOOLS AT THE LEVEL OF MARRAKECH-MOROCCO
Authors:   National School of Public Health, Morocco., Hanane Hababa , Bouchra Assarag ,   National School of Public Health, Morocco.
Published: June 2022

The measurement of less severe maternal morbidity represents many challenges forwomen during pregnancy and postpartum, and for the organization of health services. In orderto explore the different aspects of the feasibility and acceptability of implementing morbiditymeasurement tools at the primary health care network level, a qualitative and quantitativemixed descriptive study was conducted at the level of the primary health care network in theprefecture of Marrakech. The objectives are: (1) to test the tools for measuring maternalmorbiditylesssevereproposedbytheWHOanddescribethestateofplayofthismorbidity, (2) to study the feasibility and acceptability of integrating these tools into the Pregnancy and Childbirth Surveillance Program inMarrakech, and (3) to validating and proposing a new tool adapted to our Moroccan context. The data were collected by questionnaires administered face-to-face for 257 women in antenatal care and 253 women in postpartum care recruited at the level of ten health centers. Most of the women who participated in the study (55.95% antenatal and 52.17% postpartum care) were not in good health. Of these women, 35.79% had direct complications and 33.85% indirect (medical) complications. In terms of feasibility, the results suggest that the implementation of the tools presents challenges in terms of time, resources and coordination. Regarding the acceptability of the WMOs, the women surveyed perceive it as a useful information tool that promotes communication with health professionals and makes it possible to assess their state of health and ensure their holistic care.
A STUDY TO ASSESS THE EFFECT OF AN AWARENESS PROGRAMME ON KNOWLEDGE REGARDING DOMESTIC VIOLENCE AMONG WOMEN IN SELECTED RURAL AND URBAN COMMUNITIES IN PATHANAMTHITTA DISTRICT, KERALA
Authors:   Christian College of Nursing, Sihas, Shuats, Prayagraj District, Uttar Pradesh - 201009., Mathew Sheeja , Antony Soumya ,   Christian College of Nursing, Sihas, Shuats, Prayagraj District, Uttar Pradesh - 201009.
Published: June 2022

Violence against women is widely recognized as a serious human right abuse, and an important public health problem with substantial consequences physical, mental, sexual, and reproductive health.The social construction of the divide between public and private underlies the hidden nature of domestic violence against women.The position of women in the Indian society has been a very complicated one and domestic violence is a growing epidemic in Indian societies. The present study was conducted to assess the effect of an awareness programme on knowledge regarding domestic violence among women in selected rural and urban communities.A quantitative quasi experimental design was used and the study participants (100) were selected by using multi-stage cluster sampling (random selection) technique. The data was collected by using a structured knowledge questionnaire on domestic violence and awareness program was given to the participants on the same day. The post test was conducted after seven days of awareness program. Results revealed that the awareness program was effective (paired t test = 23.85) which was highly significant at 0.01 (p = 0.000). The association of baseline variables with pre-test knowledge scores was calculated by using Chi-square test. Results also revealed a significant association between educational status and type of family with pre-test knowledge scores regarding domestic violence at 0.05 level (p = 0.04). No significant association was seen with other baseline variables like: womens age, family income, area of residence, occupation, occupation, type of marriage, number of children with pre-test knowledge scores regarding domestic violence. The study concludes that awareness about the problems relatedto domestic violence will help the victims know about their rights and also will reduce the rate of the problem.
VAGINAL ELECTROSTIMULATION THERAPY IN THE SYMPTOMS OF WOMEN WITHOVERACTIVE BLADDER
Authors:   Universidad Naval, Escuela de Posgradosen Sanidad Naval, Mexico., Candice Ramon-Alcantara , M.I Tolentino-Sosa ,   Universidad Naval, Escuela de Posgradosen Sanidad Naval, Mexico., A. Suazo Sanchez ,   Departamento de SaludPublica de la Facultad de medicina, Universidad Nacional Autonoma de Mexico., J.A Barbabosa-Vilchis ,   Departamento de SaludPublica de la Facultad de medicina, Universidad Nacional Autonoma de Mexico., C.A Pantoja-Melendez ,   Departamento de SaludPublica de la Facultad de medicina, Universidad Nacional Autonoma de Mexico.
Published: June 2022

Objective: To describe the results of patients with overactive bladder managed by means of vaginal electrostimulation. Material and Methods: A descriptive study was carried out using as a basisinformation on the file of all patients treated for overactive bladderwith vaginal electrostimulation, from the period from January of 2014 to January of 2019. The therapy consisted on the application of vaginal electrostimulation for 12 30 minutes sessions. A decrease in urination frequency was determined (7.67 vs 647, p=0.001),in urinary urgency (2.07 vs 1.53, p= 0.001)and in nocturia (1.6 vs 1.02 p= 0.001). The multivariate analysis allowed us to observethat in the case of nocturia, the history of previous pelvic surgery and diseasehad a positive interaction (Previous pelvic surgery, 9.07 p=0.008and Chronic disease, 5.54 P=0.047). Discussion: The use of electrostimulation for the treatment of overactive bladder in women presents favorable results, but we must consider the history of previous surgery and comorbidities of the patients in their management.
SPORTS PRODUCTS IN THE LIGHT OF PUBLIC POLICIES
Authors: Diouf Djibril , Gueye Abdoulaye
Published: June 2022

The question is how do public sports policies, in Senegal, contribute to the promotion of local sports products, especially sports clothing? Finally, it has been shown that public sports policies provide a general framework for action and objectives to be achieved, however, insufficient to support the promotion of local sports clothing. The adoption of concrete measures, the existence of a target audience, the allocation of resources and the presence of a regulatory mechanism remain to be established.
A CROSS SECTIONAL STUDY TO ASSESS THE KNOWLEDGE, ATTITUDE AND AWARENESS OF HUMAN GENE THERAPY IN MEDICAL AND PARAMEDICAL STUDENTS OF A MEDICAL COLLEGE IN MAHARASHTRA
Authors:   Professor, Department of Biochemistry, MGM Medical College, Aurangabad., Vaishnav Deepali , Hivre Manjusha ,   Assistant Professor, Department of Biochemistry, MGM Medical College, Aurangabad., Holkar Shrirang ,   Assistant Professor, Department of Biochemistry, MGM Medical College, Aurangabad.
Published: June 2022

Background: Gene therapy is an emerging technology characterized by uncertainty in scientific knowledge with regard to benefits and risks. The development of a routinely used gene therapy to successfully fight against severe diseases is still under process. Aim: This study was conducted to assess the knowledge, attitude and awareness regarding gene therapy among Undergraduate and postgraduate students. Material and methods: A cross sectional questionnaire based study was carried out among postgraduate andundergraduate medical and allied students of the medical college for a period of six months regarding knowledge, attitude and awareness about gene therapy. Results: This study included 300 participants. Data from this study revealed a high level of awareness and knowledge of gene therapy and a positive attitude among the undergraduate and postgraduate students. Conclusion: Our results showed excellent knowledge about gene therapy among the medical and para medical students.
A REVIEW OF THE INNOVATIVE DRYING TECHNOLOGIES FOR BIOPHARMACEUTICALS
Authors:   Assistant Professor, Department of Pharmaceutics,Global College of Pharmaceutical Technology, Krishnanagar,Nadia-741102, West Bengal., Singha Roy Pritha , Joarder Gaurab ,   Undergraduate Student, Global College of Pharmaceutical Technology, Krishnanagar, Nadia-741102, West Bengal., Debnath Saibal ,   Undergraduate Student, Global College of Pharmaceutical Technology, Krishnanagar, Nadia-741102, West Bengal., Pahari Avisek ,   Undergraduate Student, Global College of Pharmaceutical Technology, Krishnanagar, Nadia-741102, West Bengal.
Published: June 2022

Reviewing data from the previous twenty to twenty-five years reveals that bio-pharmaceuticals are a sudden, dramatic, and incredibly significant finding in progressively enhancing the quality of life for patients with different kinds of malignancies, auto-immune illnesses, genetic disorders, etc. Drying technologies are a required manufacturing step in the pharmaceutical industry/production unit, and an understanding of drying technologies and how to use them is now an absolute must. With the increased demand for biopharmaceuticals, it is essential to reduce production costs without sacrificing product safety, quality, or effectiveness. The predominant commercial method for generating solid biopharmaceuticals is batch freeze-drying. However, freeze-drying is expensive compared to other procedures and is not ideal for lengthy working hours, in addition to requiring a large initial capital investment and significant energy consumption, resulting in high total expenses. This article discusses innovative drying methods for parenteral biopharmaceuticals. Spin-freeze drying, spray drying, and LynfinityÂ® Technology enable continuous manufacturing, while PRINTÂ® Technology and MicroglassificationTM manage dry particle characteristics. As a consequence, certain drying processes may need less validation. Process Analytical Technology (PAT) and offline dramatisation may give extra information on CPPs and CQAs during biopharmaceutical manufacture. These processing approaches might boost biopharmaceutical product production while reducing expenses.
VALIDATION OF G10 CLASSIFICATION IN LAPAROSCOPIC CHOLECYSTECTOMY FOR THE PREDICTION OF OPERATIVE DIFFICULTIES: AN OBSERVATIONAL STUDY
Authors: Acharyya Arindam , Kumar Dalai Chancal , Biswas Subikas , Das Arijit , Sarkar Deblina
Published: June 2022

Introduction: Laparoscopic cholecystectomy which is the gold standard of management of gall bladder pathologies has variability in terms of conversion to open procedure and operative difficulties according to the intraoperative findings.The G10 scoring system is used to predict the diificulty and outcome of surgery. Aims And Objectives: The study aimed at intraoperative assessment of gall bladder and its anatomy and surgical difficulty in laparoscopic cholecystectomy. Objective is to correlate the following factors :conversion to open procedure, surgical complication, operating time, hospital stay and readmission. Materials And Methods: All patients undergoing Laparoscopic cholecystectomy in College of Medicine and JNM Hospital, six months from the approval of Institutional Ethical Committee were used as samples. Result: 13% of difficult and 75% of extremely difficult cases were converted to open.In difficult level, 4.3% had bile duct injury, pericholecystic abcess formation and readmission whereas in extreme difficult level, 25% had bile duct injury, abcess formation and readmission. Conclusion: The more the G10 score, the more the difficulty level and there is more conversions and complications. Association of conversion,readmission and complications with degree of difficulty is statistically significant i.e. G10 classification remains a valid indicator for operative difficulties.
RARE PLATELET DISORDER GLANZMANN THROMBASTHENIA CAUSING ABNORMAL UTERINE BLEEDING A CASE REPORT AND REVIEW OF LITERATURE
Authors: Kumar Abhay , Chander Saha Subash
Published: June 2022

Glanzmann thrombasthenia is a rare genetic disorder. It is of autosomal inheritance. It usually presents as ecchymoses, petechiae, gum bleeding, musical bleeding, and menorrhagia. An acute episode of bleeding can be managed with intravenous antifibrinolytics, blood and blood products transfusion later with hormonal therapy. Newer modalities include Recombinant factor VIIa. A multidisciplinary approach is needed for the diagnosis and management of this disorder.
USE OF STHANIKA (EXTERNAL) BASTI IN SPONDYLITIS DISEASES
Authors:   M.D. Scholar, A & U Tibbia College and Hospital, New Delhi-110005., Panchal Divya , Shamkuwar Manoj ,   H.O.D., Department of Panchakarma, A & U Tibbia College and Hospital, New Delhi-110005., Jindal Nitin ,   Assistant Professor, Department of Panchakarma, A & U Tibbia College and Hospital, New Delhi-110005., Sundar Moharana Pritosh ,   M.D. Scholar, A & U Tibbia College and Hospital, New Delhi-110005., Bhardwaj Bhawna ,   M.D. Scholar, A & U Tibbia College and Hospital, New Delhi-110005., Gautam Leena ,   M.D. Scholar, A & U Tibbia College and Hospital, New Delhi-110005.
Published: June 2022

Spondylitis is a type of arthritis caused by spinal wear and tear. It can impair the spines movement and affects the nerves and other functions. Spondylolysis affects 6-10% of the general population and 25-60% of athletes. The most prevalent form of spine dysfunction in the elderly is scoliosis. The Sthanika (External)basti therapy is a localized form of svedana procedure. Warm medicated oil is pooled over specific parts of body by a special arrangement for local pain relief. Svedana is a pain-relieving therapy in and of itself. It is proved to be effective in disease like, lumbar spondylitis, ankylosing. Spondylosis, sacroiliitis, disc prolapse (IVDP).
DELINEATION OF DE QUERVAIN TENOSYNOVITIS IN SAUDI ARABIA AND LITERATURE REVIEW
Authors:   Department of Plastic Surgery, King Abdulaziz Medial City, Riyadh, Saudi Arabia., Mohammad AlMeshal Obaid , Mohammad Al Sahli Alaa ,   College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia., Ibrahim Hadadi Ali ,   Department of Plastic Surgery, King Abdulaziz Medial City, Riyadh, Saudi Arabia.
Published: June 2022

Background: De Quervain Tenosynovitis was first reported in the literature in 1895 by Fritz De Quervain, describing entrapment tendinitis of the first dorsal compartment of the wrist. This study conducted to evaluate our institutions experience with De Quervain Tenosynovitis patients Methods :Retrospective cross-sectional hospital based study conducted at King Abdul-Aziz Medical City a tertiary care center in Riyadh.The study included all De Quervain Tenosynovitis cases treated in our institution between January 2008 and December 2014. Results: The study included 29 patients. Mean (Interquartile range) age was 42 (24-78) years and 19/29 (66%) were female. Mean (Interquartile range) BMI at the diagnosis was 30 (21-42). The most common radiological finding was distal radius cortical ridging17/29 (59%). Conservative treatment was initiated in 17/29 patients (59%), yet no clinical improvement noted and all the cases required surgical intervention 29/29 (100%). The intraoperative septum was observed in all cases 29/29 (100%). Conclusion: Routine wrist X-rays in DeQuervain Tenosynovitis is cost-effective and should be considered to guide the treatment course with low threshold for surgical intervention might be warranted particularly in obese female patient.
CARCINOME PAPILLAIRE INTRA-KYSTIQUE DU SEIN: QUELLE INDICATION DE LA RADIOTHERAPIE? A TRAVERS UN CAS CLINIQUE ET UNE REVUE DE LA LITTERATURE
Authors:   Service de Radiotherapie, Centre Hospitalier Universitaire Hassan II., Farhane Fz. , Alami Z. ,   Service de Radiotherapie, Centre Hospitalier Universitaire Hassan II., Hassani W. ,   Service de Radiotherapie, Centre Hospitalier Universitaire Hassan II., Bouhafa T. ,   Service de Radiotherapie, Centre Hospitalier Universitaire Hassan II.
Published: June 2022

Le Carcinome papillaire intra-kystique (CPIK) du sein est une entite tres rare et represente 0,5 Ã 1% de lensemble des carcinomes mammaires. Il se caracterise generalement par une croissance lente avec un bon pronostic. Sa prise en charge therapeutique nest pas consensuelle, notamment la place de la radiotherapie apres chirurgie. Nous presentons ici le cas dune patiente presentant un CPIK pure du sein traite par une chirurgie conservatrice suivie dune radiotherapie adjuvante tout en rapportant une revue de la litterature dans le but de discuter la place de la radiotherapie dans le traitement adjuvant de ce type de carcinome mammaire.
SHORT TERM FUNCTIONAL OUTCOME OF CLOSED REDUCTION AND FIXATION OF COLLES FRACTURE USING MODIFIED-JOSHIS EXTERNAL STABALIZATION SYSTEM - A PROSPECTIVE STUDY
Authors: Mehra Sameer , Dang Balkrishna
Published: June 2022

Colles fracture is the most common fracture seen in adult population. It is never an isolated fracture of the distal radius, but is associated with fracture of ulna styloid which may be displaced or undisplaced instability of the distal radio-ulnar joint complex and may be associated with injury to triangular fibro cartilaginous complex. The aim of study was to determine functional outcome of management of closed reduction and fixation of comminuted colles fracture using a rigid and stable modified-Joshis External Stabalisation System as soon as possible. In our study we have tried to bring associated soft tissue and bony injuries around the wrist joint as a highlighter and focused on fixation and restoration of anatomy to near normal with fixation of all the above mentioned injuries without exposing the joint, and as an immediate and definative management. Out of a total of 30 patients included, 26 patients had an excellent outcome as measured using quick-disability arm shoulder hand score and modified-mayo wrist scoring system. One patient had a superficial pin tract infection and was managed with oral antibiotics. The patients were able to resume the activities of daily living by end of eight weeks. It can be concluded that this method can be employed in immediate and definative management of comminuted colles fractures as it leads to a better functional outcome, lesser hospital stay, early mobilization of the joint, lesser exposure to radiation, avoids joint exposure, has a low learning curve, early resumption of activities of daily living and avoids re-surgery at a later date for implant removal.
m1A-pred: Prediction of Modified 1-methyladenosine Sites in RNA
Sequences through Artificial Intelligence
Authors: Suleman Muhammad Taseer , Khan Yaser Daanial
Published: June 2022

Background:

The process of nucleotides modification or methyl groups addition to nucleotides is known as post-transcriptional modification (PTM). 1-methyladenosine (m1A) is a type of PTM formed by adding a methyl group to the nitrogen at the 1st position of the adenosine base. Many human disorders are associated with m1A, which is widely found in ribosomal RNA and transfer RNA.

Objective:

The conventional methods such as mass spectrometry and site-directed mutagenesis proved to be laborious and burdensome. Systematic identification of modified sites from RNA sequences is gaining much attention nowadays. Consequently, an extreme gradient boost predictor, m1A-Pred, is developed in this study for the prediction of modified m1A sites.

Method:

The current study involves the extraction of position and composition-based properties within nucleotide sequences. The extraction of features helps in the development of the features vector. Statistical moments were endorsed for dimensionality reduction in the obtained features.

Results:

Through a series of experiments using different computational models and evaluation methods, it was revealed that the proposed predictor, m1A-pred, proved to be the most robust and accurate model for the identification of modified sites.

Availability and Implementation:

To enhance the research on m1A sites, a friendly server was also developed which was the final phase of this research.
Investigating the Impact of Covalent and Non-covalent Binding Modes of
Inhibitors on Bruton’s Tyrosine Kinase in the Treatment of B Cell
Malignancies - Computational Insights
Authors: Issahaku Abdul Rashid , Soliman Mahmoud E.S.
Published: June 2022

Background:

Bruton tyrosine kinase plays a key role in the survival, proliferation, activation and differentiation of B-lineage cells and the signaling of other receptors. It is overexpressed and constitutively active in the pathogenesis of B cell malignancies and has therefore become a target for therapeutic intervention. Some success has been achieved in the discovery of small molecules especially in the development of irreversible inhibitors. However, these inhibitors are punctuated by off target effects and have also become less effective in patients with mutations at Cys481. This motivated the search for inhibitors with improved efficacy and different binding modes.

Methods:

In this study we employed two new second generation inhibitors with different binding modes, Zanubrutinib and AS-1763, which are at various levels of clinical trials to highlight the molecular determinants in the therapeutic inhibition of BTK through computational studies.

Results:

This study revealed Zanubrutinib and AS-1763 exhibited free total binding energies of -98.76±4.63kcal/mol and -51.81±9.94kcal/mol respectively with Zanubrutinib engaging in peculiar hydrogen bond interactions with the hinge residues Glu475 and Met477 including Asn484, and Tyr485 whiles AS-1763 engaged Lys430, Asp539, and Arg525. These residues contributed the most towards the free total binding energy with energies above -1.0kcal/mol. The compounds further interacted differentially with other binding site residues through pi-alkyl, pi-cation, pi-anion, pi-pi-T-shaped, pi-sigma, pi-sulfur and pi-donor hydrogen bonds and Van der Waals interactions. These interactions resulted in differential fluctuations of the residues with consequential unfolding of the protein.

Conclusion:

Insights herein would be useful in guiding the discovery of more selective and potent small molecules.
Clinical Patterns of Primary Biliary Cholangitis: Comparison Between
Two European Case Series
Authors: Abenavoli Ludovico , Procopio Anna Caterina , Cinaglia Pietro , Zanza Christian , Grazie Claudio Delle , Longhitano Yaroslava , Libicherova Pavla , Luzza Francesco
Published: June 2022

Background:

Primary biliary cholangitis (PBC) is a chronic autoimmune cholestatic liver disease characterized by progressive destruction of the intrahepatic bile ducts, followed by fibrous substitution of the ducts and potential evolution in cirrhosis. The geographical disparity in the preva-lence of PBC suggests a possible role of environmental factors in developing the disease. We ana-lyzed two groups of patients with different geographical prevalence.

Methods:

This study concerned the analysis of 14 Caucasian patients in two groups: ten patients en-rolled in the Digestive Diseases Unit, University of Catanzaro (Italy), and four patients enrolled in the Department of Hepatology, University Hospital Kràlovskè Vinohrady of Prague (Czech Repub-lic). The statistical analysis was performed using the software IBM SPSS (v. 20, Windows).

Results:

The Italian group showed a statistically significant difference in the total bilirubin values at diagnosis and during the last control (0.74±0.267 vs. 0.56±0.246; p-value: 0.013). Moreover, the comparison between the two groups showed a statistically significant difference in the serum albumin values at the time of the last control (4.6±0.231 vs. 4.15±0.532; p-value: 0.048).

Conclusion:

Our data indicate an effective difference in the onset and clinical presentation between our two groups. More epidemiologic, prospective, and multicenter research projects are warranted to advance PBC knowledge in Europe.
Characterization of Functionalized PLGA Nanoparticles Loaded with Mangiferin
and Lupeol, and their Effect on BEAS-2B and HepG2 Cell Lines
Authors: Fabián Razura-Carmona Francisco , Mayra Herrera-Martínez , Manuel Zamora-Gasga Víctor , Guadalupe Sáyago-Ayerdi Sonia , Alejandro Pérez-Larios , Alberto Sánchez-Burgos Jorge
Published: June 2022

:

Lupeol (LP) and Mangiferin (MG) have beneficial effects on health. However, their pharmacokinetic properties
can affect their bioavailability when administered orally. Therefore, their incorporation as a vehicle in a hybrid
matrix of ZnO and PLGA could contribute to improving bioavailability

Methods:

This study aimed to develop this matrix and evaluate the optical and bioactive properties obtained by the
solvent emulsion and evaporation methods. These were subjected to processes to evaluate their bioactivity in relation
with topoisomerase.

Results:

Functionalized treatment number 15 (TF15) showed the best results in studies of controlled release and encapsulation
efficiency of lupeol (LP) and mangiferin (MG) (60.01 ± 1.24% and 57.71 ± 1.94%). The best treatment
showed behavior as a topoisomerase II inhibitor (18.60 ± 1.55). The nanoparticles developed in this study did not show
a cytotoxic effect on BEAS-2B, while HepG2, showed a decrease in viability (IC50 1549.96 ± 174.62 μg/mL). However,
although the hemolytic activity is not shown after 1 h of exposure, morphological alterations caused by TF15 are
observed at concentrations of 2500 and 1250 μg/mL.

Conclusion:

The TF15 treatment shown maintaining antitopoisomerasa activity does and does not cytotoxixity for
healthy cells and slows down the growth of cancer cells.
Tivozanib: A New Hope for Treating Renal Cell Carcinoma
Authors: Chawla Pooja A. , Passi Indu , Billowria Koushal , Kumar Bhupinder
Published: June 2022

Background:

Renal cell carcinoma (RCC) is a diverse collection of malignancies with varying histological
characteristics, molecular changes, prognosis, and therapeutic response. Tivozanib was first approved in March 2021
by USFDA with the brand name Fotivda. Tivozanib hydrochloride monohydrate is an oral medication that is used to
treat relapsed or refractory renal cell carcinoma.

Objective:

In this review, we explain renal cell carcinoma and its different types of treatment by the anti-renal carcinoma
drugs.

Methods:

A comprehensive literature search was conducted in the relevant databases, like ScienceDirect, PubMed,
ResearchGate, and Google Scholar, to identify the studies.

Conclusion:

Tivozanib is an oral VEGFR-1, VEGFR-2, and VEGFR-3 tyrosine kinase inhibitor that is extremely
selective and powerful. It has much less affinity for other receptor tyrosine kinases than multi-targeted TKIs now in
clinical use. Because of its long half-life in circulation, it may be able to block VEGFRs more consistently. Doserelated
controllable hypertension is its most commonly seen drug-related side event. Fatigue, hoarseness, and diarrhea,
which are all common side effects, are not dose-related. Because of its target specificity, tivozanib can work well with
other medications that have low side effects. Blocking both the VEGF and mTOR signaling pathways at the same time
provides the benefit of synergistic antitumor efficacy while also preventing treatment resistance. Thus, overall we can
say that the drug tivozanib is suitable for treatment in patients with renal cell carcinoma and can be investigated in
multi-center clinical trials.
Bcl11a and the Correlated Key Genes Ascribable to Globin Switching: An
In-silico Study
Authors: Modarressi Mohammad Hossein , Motlagh Fatemeh Movahedi , Soleimanpour-Lichaei Hamid Reza , Emami Ali , Kadkhoda Sepideh , Shamsara Mehdi , Rasti Azam
Published: June 2022

Background:

Reactivation of HbF is a potential strategy to ameliorate symptoms of hemoglobinopathies such as sickle cell disease and b-thalassemia. After birth, there is a switch from fetal to adult hemoglobin, for which the molecular mechanisms and key regulators await further understanding in order to develop effective methods for HbF reactivation. BCL11A, one of the major HbF reactivation regulators, demonstrates no significant changes at transcriptional levels in F erythroblasts compared to the non-HbF expressing cells. Therefore, it is possible that post-transcriptional regulation and epigenetic effects, for which the miRNAs play an important role, are the primary causes of the decreased BCL11A protein level in adult erythroblasts.

Objective:

The aim of this paper is to determine the differentially expressed mRNAs and miRNAs of erythroblasts in HSCs from the fetal liver and bone marrow.

Methods:

Raw high-throughput sequencing data (GSE110936, GSE90878) was downloaded from Gene Expression Omnibus (GEO) database. After RNAseq analysis, several data sets and tools were used to select key genes and examine selection validation.

Results:

We selected 42 DEmRNAs and nine DEmiRs, including hsa-let-7f-5p, hsa-miR-21-5p, hsa-miR-22-3p, hsa-miR-126-5p, hsa-miR-146b-5p, hsa-miR-181a-5p, hsa-miR-92a-3p, hsa-miR-25-3p and hsa-miR-191-5p. Furthermore, hub genes including hist1h2bl, al133243.2, trim58, abcc13, bpgm, and fam210b were identified in the coexpression network, as well as RPS27A in the PPI network. Functional analysis revealed that these DEmRNAs and DEmiRs may play a role in gene expression regulation at multiple levels. Gene set enrichment analysis, in particular, revealed a possible role for genes in the globin switching process.

Conclusion:

According to our findings, a number of the DEmRNAs and DEmiRs may play significant roles in globin switching regulation and thus have the potential to be applied for HbF reactivation.
Treatment of Dissociated Vertical Deviation by Combined Recession–Resection of the Superior Rectus Muscle versus Recession with Posterior Fixation Suture
Authors: Mattout Hala K. , Fouda Sameh M.
Published: June 2022

Background:

Management of dissociated vertical deviation (DVD) is still a matter of controversy in strabismus practice. Different surgical techniques are available, ranging from the weakening of the superior rectus or inferior oblique muscles to strengthening of the inferior rectus muscle, with variable success rates.

Objective:

To report the outcomes of correcting DVD by combined recession-resection of the superior rectus muscle and to compare the results with those of superior rectus muscle (SR) recession with posterior fixation sutures.

Methods:

The medical records of patients who had a surgical correction for DVD were retrospectively reviewed. Two groups of patients were identified; Group I (29 patients) was treated with the combined recession –resection of the SR and group II (37 patients) was treated by SR recession with posterior fixation sutures (Faden). Collected preoperative data included age, best-corrected visual acuity, presence of amblyopia, history of previous surgeries and angle of DVD. Operative data such as amount of SR recession and operative time were also extracted. The outcome measures taken at the final postoperative follow up visit included the surgical success rate which is identified as the percentage of patients with absent manifest DVD and the amount of residual latent deviation measured by prism cover test.

Results:

The mean follow-up period for all patients was 22.6 ±4.6 months. In the last follow-up visit, the surgical success rate was 76% in the combined recession-resection group and 73% in the faden group with no significant difference between both groups (p=0.8). No significant difference was found in the residual latent deviation in both groups as well. The recorded surgical time was significantly shorter in the combined recession- resection group (p<0.001). The reported complications included mild, temporary limitation of elevation without hypotropia in 5 patients (2 in group I (7%) and 3 patients in group II (8%)) with no significant difference between both groups (p=0.8).

Conclusion:

Combined recession-resection of SR is as effective as SR recession with posterior fixation suture in the management of DVD with the advantages of easier technique and less surgical time.
Phytochemistry and Medicinal Importance of Herb Mimosa pudica:
A Review
Authors: Fernandes Venzil W. , Gaonkar Santosh L. , Shetty Nitinkumar S.
Published: June 2022

Background:

Mimosa pudica is a tropical weed that belongs to the legume family and is native to South America. This plant is also found in different regions of India such as Andhra Pradesh, Telangana, Karnataka, Kerala, Orissa, and Tamil Nadu. It is a known plant that can show thigmonasty. The plant is known to possess diverse biological properties, such as antimicrobial activity, antidiabetic activity, anticonvulsant activity, antivenom activity, antiulcer activity, antifertility, antioxidant effect, antihistamine, anti-inflammatory activity, wound healing effect, antitumor activity, antifungal activity, antinociceptive activity, diuretic effect, etc. The herb is traditionally being used for ages, to treat urogenital disorders, dysentery, sinus piles, and used for wound healing.

Objective:

Review stresses on plant movement displayed by the plant Mimosa pudica and the responsible phytocompounds. The bioactive compounds isolated by various researchers to date and the pharmacological activities displayed by the plant are thoroughly reviewed.

Methods:

The literature related to phytochemical and pharmacological studies has been collected from various databases such as Scopus, PubMed, various student papers, publications, and internet sources from 1877 to 2021.

Results:

The net result of the study showed that Mimosa pudica possesses various phytochemicals that are responsible for plant movement and pharmacological activities that are further proved by computational studies. Further, nanoparticles and hydrogels from Mimosa pudica are been studied in recent years for their various applications.

Conclusion:

The herb seems to be a promising natural medicine to undergo further investigation as evidenced by its diverse biological profile.
Design and Development of a Data Structure Visualisation System Using
the Ant Colony Algorithm
Authors: Ansari Mohd Dilshad , Li Xiaojuan , Khan Mudassir
Published: June 2022

Aim:

A data structure visualisation system uses object-oriented thinking and COM
technology to dynamically and interactively simulate and track data structure algorithms and realize
the dynamic synchronisation and visualisation of abstract data structures and algorithms using
the data modelling function and self-test function.

Background:

Teaching data structures and algorithms is difficult because of their abstraction and
dynamics; the use of icons in classroom teaching can be partially abstracted into intuition, but
analysing the instantaneous dynamic characteristics of the object and the dynamic execution process
of the algorithm is difficult.

Objective:

A data structure visualisation system employs a data modelling function, visual data
structures, a user-friendly and flexible interface, and multipath features for multilevel users. Such
systems can be designed more effectively by using the ant colony algorithm.

Methods:

The more the ants pass by a certain path, the higher the concentration of residual pheromone,
and the higher the probability of the subsequent ant selecting that path. Therefore, the individuals
in an ant colony communicate messages and cooperate with each other for foraging.

Results:

The resulting speedup ratio indicates that the speedup is smaller when the number of
nodes is 100 or more; the acceleration is higher when the node reaches a certain scale, and the
speedup ratio does not change considerably. In this study, the traffic simulation software VISSIM
was used to generate road network data; the generated traffic data were analysed and used to design
a traffic network data structure.

Conclusion:

The traffic network data model oriented to the ant colony algorithm was established
through abstraction. Accordingly, a parallel ant colony algorithm based on cloud computing was
implemented. Finally, a Hadoop cloud computing platform was established and used to run and
test the parallel ant colony algorithm program; several experiments were conducted, and the experimental
results were analysed concurrently.