bluuebunny/crossref_metadata_2025 huggingface dataset:
Direct Oral Anticoagulants versus Warfarin in Octogenarians with Nonvalvular Atrial Fibrillation: A Systematic Review and Meta-Analysis
Authors: Bonanad Clara , García-Blas Sergio , Torres Llergo Javier , Fernández-Olmo Rosa , Díez-Villanueva Pablo , Ariza-Solé Albert , Martínez-Sellés Manuel , Raposeiras Sergio , Ayesta Ana , Bertomeu-González Vicente , Tarazona Santabalbina Francisco , Facila Lorenzo , Vivas David , Gabaldón-Pérez Ana , Bodi Vicente , Nuñez Julio , Cordero Alberto
Published: November 2021

Direct oral anticoagulants (DOACs) have been demonstrated to be more effective and safer than vitamin-K antagonist (VKA) for stroke prevention in patients with nonvalvular atrial fibrillation (AF). This meta-analysis aims to assess the effect of DOACS vs. VKA in patients ≥ 80 and AF. Primary endpoints were stroke or systemic embolism and all-cause death. Secondary endpoints included major bleeding, intracranial bleeding, and gastrointestinal bleeding. A random-effects model was selected due to significant heterogeneity. A total of 147,067 patients from 16 studies were included, 71,913 (48.90%) treated with DOACs and 75,154 with VKA (51.10%). The stroke rate was significantly lower in DOACs group compared with warfarin group (Relative risk (RR): 0.72; 95% confidence interval (CI): 0.63–0.82; p < 0.001). All-cause mortality was significantly lower in DOACs group compared with warfarin group (RR: 0.82; 95% CI: 0.70–0.96; p = 0.012). Compared to warfarin, DOACs were not associated with reductions in major bleeding (RR: 0.85, 95% CI 0.69–1.04; p = 0.108) or gastrointestinal bleeding risk (RR: 1.08, 95% CI 0.76–1.53; p = 0.678) but a 43% reduction of intracranial bleeding (RR: 0.47, IC 95% 0.36–0.60; p < 0.001) was observed. Our meta-analysis demonstrates that DOACs are effective and safe with statistical superiority when compared with warfarin in octogenarians with AF.
Macular Morpho-Functional and Visual Pathways Functional Assessment in Patients with Spinocerebellar Type 1 Ataxia with or without Neurological Signs
Authors: Ziccardi Lucia , Cioffi Ettore , Barbano Lucilla , Gioiosa Valeria , Falsini Benedetto , Casali Carlo , Parisi Vincenzo
Published: November 2021

Spinocerebellar ataxia type 1 (SCA-ATXN1) is an autosomal dominant, neurodegenerative disease, caused by CAG repeat expansion in the ataxin-1 gene (ATXN1). In isolated reports of patients with neurological signs [symptomatic patients (SP)], macular abnormalities have been described. However, no reports exist about macular anomalies in SCA1 subjects carrying the ATXN1 mutation without neurological signs [not symptomatic carriers (NSC)]. Therefore, the main aim of our work was to evaluate whether the macular functional and morphological abnormalities could be detectable in SP, genetically confirmed and with neurological signs, as well as in SCA-ATXN1-NSC, harboring pathogenic CAG expansion in ATXN1. In addition, we investigated whether the macular involvement could be associated or not to an impairment of RGCs and of their fibers and of the neural conduction along the visual pathways. Herein, nine SCA-ATXN1 subjects (6 SP and 3 NSC) underwent the following examinations: visual acuity and chromatic test assessments, fundus oculi (FO) examination, macular and peripapillary retinal nerve fiber layer thickness (RNFL-T) analysis by Spectral domain-Optical Coherence Tomography (Sd-OCT) acquisition, multifocal electroretinogram (mfERG), pattern reversal electroretinogram (PERG) and visual evoked potentials (VEP) recordings. In four eyes of two SP, visual acuity reduction and chromatic abnormalities were observed; in three of them FO changes associated with macular thinning and outer retinal defects were also detected. In three NSC eyes, slight FO abnormalities were associated with qualitative macular morphological changes. By contrast, abnormal mfERG responses (exclusively from foveal and parafoveal areas) were detected in all SP and NSC (18 eyes). No abnormalities of PERG values, RNFL-T, and VEP responses were found, but in one SP, presenting abnormal papillo-macular bundle neural conduction. Results from our SCA-ATXN1 cohort suggest that a macular dysfunction, detectable by mfERG recordings, may occur in the overt disorder, and unexpectedly in the stage of the disease in which there is still an absence of neurological signs. In NSC, an exclusive dysfunction of preganglionic macular elements can be observed, and this is associated with both normal RGCs function and neural conduction along the visual pathways.
Factors Influencing the Evolution of Pulmonary Hypertension in Previously Healthy Subjects Recovering from a SARS-CoV-2 Infection
Authors: Tudoran Cristina , Tudoran Mariana , Lazureanu Voichita Elena , Marinescu Adelina Raluca , Cut Talida Georgiana , Oancea Cristian , Pescariu Silvius Alexandru , Pop Gheorghe Nicusor
Published: November 2021

(1) Background: While the COVID-19 pandemic has been persisting for almost 2 years, more and more people are diagnosed with residual complications such as pulmonary hypertension (PH) and right ventricular dysfunction (RVD). This study aims to evaluate the course of PH and borderline PH (BPH) at 3 and 6 months after the acute COVID-19 infection and investigate if there are differences regarding its evolution between the patients from the first three waves of this disease. (2) Methods: We analyzed, by transthoracic echocardiography (TTE), the 3 and 6 months’ evolution of the echocardiographically estimated systolic pulmonary artery pressures (esPAP) in 116 patients already diagnosed with PH or BPH due to COVID-19 during the first three subsequent waves of COVID-19. (3) Results: We documented a gradual, statistically significant reduction in esPAP values, but also an improvement of the parameters characterizing RVD after 3 and 6 months (p < 0.001). This evolution was somewhat different between subjects infected with different viral strains and was related to the initial severity of the pulmonary injury and PH (adjusted R2 = 0.722, p < 0.001). (4) Conclusions: PH and RVD alleviate gradually during the recovery after COVID-19, but in some cases, they persist, suggesting the activation of pathophysiological mechanisms responsible for the self-propagation of PH.
The Relationship of ABCB1/MDR1 and CYP1A1 Variants with the Risk of Disease Development and Shortening of Overall Survival in Patients with Multiple Myeloma
Authors: Zmorzynski Szymon , Wojcierowska-Litwin Magdalena , Popek-Marciniec Sylwia , Szudy-Szczyrek Aneta , Styk Wojciech , Chocholska Sylwia , Filip Agata Anna
Published: November 2021

(1) Background: The aim of our study was to analyze the possible relationship of ABCB1 and CYP1A1 gene variants with susceptibility and outcome of multiple myeloma (MM); (2) Methods: Genomic DNA samples from 110 newly-diagnosed MM patients and 100 healthy blood donors were analyzed by methods-PCR-RFLP (for ABCB1 3435C > T, CYP1A1 6235T > C—m1), automated DNA sequencing (for ABCB1 1236C > T, 2677G > T/A) and allele-specific PCR (for CYP1A1 4889A > G—m2); (3) Results: The genotypic frequencies of CYP1A1 4889A > G variant were not in Hardy-Weinberg equilibrium for MM patients. The presence of m1 and m2 CYP1A1 alleles decreased the risk of MM—OR = 0.49 (p = 0.011) and OR = 0.27 (p = 0.0003), respectively. In turn, TT genotype (ABCB1 2677G > T/A) increased the risk of this disease (p = 0.007). In the multivariate Cox analysis CT + TT genotypes (ABCB1 3435C > T) were associated with decreased risk of death (HR = 0.29, p = 0.04). In log-rank test in patients with CT genotype (ABCB1 3435C > T) was observed association of overall survival with the type of treatment; (4) Conclusions: Our findings suggest that T-alleles of ABCB1 2677G > T/A and m1/m2 alleles of CYP1A1 affected the susceptibility of MM. Moreover, T-allele of ABCB1 3435C > T might be independent positive prognostic factor in MM.
Preoperative Ultrasonography in the Evaluation of Suspected Familial Non-Medullary Thyroid Cancer: Are We Able to Predict Multifocality and Extrathyroidal Extension?
Authors: Grani Giorgio , Cera Gianluca , Conzo Giovanni , Del Gatto Valeria , di Gioia Cira Rosaria Tiziana , Maranghi Marianna , Lucia Piernatale , Cantisani Vito , Metere Alessio , Melcarne Rossella , Borcea Maria Carola , Scorziello Chiara , Menditto Rosa , Summa Marco , Biffoni Marco , Durante Cosimo , Giacomelli Laura
Published: November 2021

Family history of thyroid cancer increases the risk of harboring thyroid malignancies that end up having extrathyroidal extension (ETE) and multifocality on histology; some authors suggest a more aggressive surgical approach. Their pre-operative identification could allow more conservative surgical procedures if none of these features are suspected. Our aim was to assess if neck ultrasonography could identify or exclude multifocality or ETE in these patients to tailor the extent of surgery. This retrospective study included patients with previous thyroid surgery, ≥1 first-grade relative with thyroid cancer, and who had undergone pre-surgical ultrasound. ETE was suspected in the case of thyroid border interruption or gross invasion of perithyroidal tissues. Multiple suspicious nodules were defined as suspicion of multifocal cancer. The cohort consisted of 45 patients (median age 49 years, 40 with thyroid cancer, 30 females). The positive predictive value of ultrasonography in predicting multifocality and ETE was 57.14% (25.25–84.03) and 41.67% (21.5–65.1%), respectively, while the negative predictive values were 63.2% (56.4–69.4%) and 72.7% (63.3–80.5%). Pre-operative ultrasound examination is unable to reliably identify or exclude multifocal disease or extrathyroidal extension. In patients scheduled for surgery and with a first-degree relative affected by DTC, a “negative” pre-operative US report does not exclude the potential finding of multifocality and ETE at final histopathology.
Cardiac Surgery Associated AKI Prevention Strategies and Medical Treatment for CSA-AKI
Authors: Ostermann Marlies , Kunst Gudrun , Baker Eleanor , Weerapolchai Kittisak , Lumlertgul Nuttha
Published: November 2021

Acute kidney injury (AKI) is common after cardiac surgery. To date, there are no specific pharmacological therapies. In this review, we summarise the existing evidence for prevention and management of cardiac surgery-associated AKI and outline areas for future research. Preoperatively, angiotensin-converting enzyme inhibitors and angiotensin receptor blockers should be withheld and nephrotoxins should be avoided to reduce the risk. Intraoperative strategies include goal-directed therapy with individualised blood pressure management and administration of balanced fluids, the use of circuits with biocompatible coatings, application of minimally invasive extracorporeal circulation, and lung protective ventilation. Postoperative management should be in accordance with current KDIGO AKI recommendations.
Diaphragmatic Point-of-Care Ultrasound in COVID-19 Patients in the Emergency Department—A Proof-of-Concept Study
Authors: Pivetta Emanuele , Cara Irene , Paglietta Giulia , Scategni Virginia , Labarile Giulia , Tizzani Maria , Porrino Giulio , Locatelli Stefania , Calzolari Gilberto , Morello Fulvio , Maule Milena Maria , Lupia Enrico
Published: November 2021

Background: Lung Ultrasound Evaluation (LUS) is usefully applied in the Emergency Department (ED) to patients with suspected or confirmed COVID-19. Diaphragmatic Ultrasound (DUS) may provide additional insight into ventilatory function. This proof-of-concept study aimed to evaluate the feasibility of LUS and DUS in a third level ED during the COVID-19 pandemic. Methods: Adult patients presenting with COVID-19 symptoms were eligible. After the physical examination, both LUS and DUS (i.e., diaphragmatic motion and thickness) were performed. All patients were followed after 30 days to determine their need for ventilation, admission, and/or a new ED evaluation after discharge. The diagnostic accuracies of diaphragm measurements in assessing the risk of the 30-day outcome were calculated as well as the measurements’ usefulness. Bland–Altman plots were used for comparing bedside and off-line diaphragm measurements. Results: 118 patients were enrolled. Median thickness and motion were 1.7 mm (iqr 0.4) and 1.8 cm (iqr 0.7), respectively, with a mean difference of 0.009 mm (95% CI −0.037–0.056 mm) and −0.051 cm (95% CI −0.108–0.006 cm), respectively. The 30-day outcome was associated with an increase in thickness (OR 5.84, 95% CI 0.96–35.4), and a lower motion (OR 0.49, 95% CI 0.2–1.21). Conclusion: DUS seemed to be feasible and reliable in the ED in a population of patients presenting with symptoms related to COVID-19 infection.
Risk of Suicidal Behavior in Children and Adolescents Exposed to Maltreatment: The Mediating Role of Borderline Personality Traits and Recent Stressful Life Events
Authors: Marques-Feixa Laia , Moya-Higueras Jorge , Romero Soledad , Santamarina-Pérez Pilar , Rapado-Castro Marta , Zorrilla Iñaki , Martín María , Anglada Eulalia , Lobato María José , Ramírez Maite , Moreno Nerea , Mayoral María , Marín-Vila María , Arias Bárbara , Fañanás Lourdes ,   EPI-Young Stress GROUP
Published: November 2021

Childhood maltreatment (CM) is associated with increased non-suicidal self-injury (NSSI) and suicidal behavior (SB), independently of demographic and mental health conditions. Self-Trauma Theory and Linehan’s Biopsychosocial Model might explain the emergence of Borderline Personality Disorder (BPD) symptoms as mediators of the association between CM and the risk of SB. However, little is known regarding such relationships when the exposure is recent for young persons. Here, we study 187 youths aged 7–17, with or without mental disorders. We explore CM experiences (considering the severity and frequency of different forms of neglect and abuse), recent stressful life events (SLEs), some BPD traits (emotion dysregulation, intense anger and impulsivity), and the risk of SB (including NSSI, suicide threat, suicide ideation, suicide plan and suicide attempt). We study the direct and mediating relationships between these variables via a structural equation analysis using the statistical software package EQS. Our findings suggest that youths exposed to more severe/frequent CM have more prominent BPD traits, and are more likely to have experienced recent SLEs. In turn, BPD traits increase the risk of SLEs. However, only emotion dysregulation and recent SLEs were found to be correlated with SB. Therefore, targeted interventions on emotion dysregulation are necessary to prevent NSSI or SB in children and adolescents exposed to CM, as is the minimization of further SLEs.
Proximal Aortic Dilatation and Pulmonary Valve Replacement in Patients with Repaired Tetralogy of Fallot: Is There a Relationship? A Cardiac Magnetic Resonance Imaging Study
Authors: Mohammed Ahmed Farghal A. , Frick Michael , Kerst Gunter , Hatam Nima , Elgamal Mohamed-Adel F. , Essa Karam M. , Hövels-Gürich Hedwig H. , Vazquez-Jimenez Jaime F. , Zayat Rashad
Published: November 2021

Aortopathy is a known complication whose incidence is growing within the population of tetralogy of Fallot (TOF) patients. Its pathology and relationship with other comorbidities remain unclear. This study was designed to determine the prevalence and predictors of proximal aortic dilatation after TOF repair. We retrospectively investigated all patients who underwent follow-up cardiac magnetic resonance imaging (CMR; at least 4 years after TOF repair) between March 2004 and December 2019. The dimensions at the ascending aorta (AAo) and sinus of Valsalva (SoV) levels were measured. Aortic dilatation was defined as an internal aortic diameter that was >2 standard deviation of the previously published normal values. We included 77 patients (mean age 28.9 ± 10.5 years, 41.5% female, mean follow-up of 24.5 ± 8.1 years). AAo and SoV were dilated in 19 (24.6%) and 43 (55.8%) patients, respectively. Patients with dilated AAo and SoV were older during the corrective surgery (p < 0.001 and p = 0.004, respectively) and during CMR (p = 0.002 and 0.024, respectively) than patients without AAo and SoV dilatation. Patients of the dilated AAo group were more likely to have prior palliative shunt (p = 0.008), longer shunt duration (p = 0.005), and a higher degree of aortic valve regurgitation (AR) fraction (p < 0.001) and to undergo pulmonary (PVR) and/or aortic valve replacement (p < 0.001 and p = 0.013, respectively). PVR (p = 0.048, odds ratio = 6.413, and 95% CI = 1.013–40.619) and higher AR fraction (p = 0.031, odds ratio = 1.194, and 95% CI = 1.017–1.403) were independent predictors for AAo dilatation. Aortopathy is a common progressive complication that may require reintervention and lifelong follow-up. Our study shows that proximal aortic dilatation may be attributed to factors that increase the volume overload across the proximal aorta, including late corrective surgery and palliative shunt. We also found that PVR and higher AR fraction are independent predictors of AAo dilatation.
Ground Reaction Forces during Vertical Hops Are Correlated with the Number of Supervised Physiotherapy Visits after Achilles Tendon Surgery
Authors: Sikorski Łukasz , Czamara Andrzej
Published: November 2021

The objective of this study was to assess the effectiveness of, and the correlation between, an average of 42 supervised physiotherapy (SVPh) visits for the vertical ground reaction forces component (vGRF) using ankle hops during two- and one-legged vertical hops (TLH and OLH, respectively), six months after the surgical suturing of the Achilles tendon using the open method (SSATOM) via Keesler’s technique. Hypothesis: Six months of supervised physiotherapy with a higher number of visits (SPHNVs) was positively correlated with higher vGRF values during TLH and OLH. Group I comprised male patients (n = 23) after SSATOM (SVPh x = 42 visits), and Group II comprised males (n = 23) without Achilles tendon injuries. In the study groups, vGRF was measured during TLH and OLH in the landing phase using two force plates. The vGRF was normalized to the body mass. The limb symmetry index (LSI) of vGRF values was calculated. The ranges of motion of the foot and circumferences of the ankle joint and shin were measured. Then, 10 m unassisted walking, the Thompson test, and pain were assessed. A parametric test for dependent and independent samples, ANOVA and Tukey’s test for between-group comparisons, and linear Pearson’s correlation coefficient calculations were performed. Group I revealed significantly lower vGRF values during TLH and OLH for the operated limb and LSI values compared with the right and left legs in Group II (p ≤ 0.001). A larger number of visits correlates with higher vGRF values for the operated limb during TLH (r = 0.503; p = 0.014) and OLH (r = 0.505; p = 0.014). An average of 42 SVPh visits in 6 months was insufficient to obtain similar values of relative vGRF and their LSI during TLH and OLH, but the hypothesis was confirmed that SPHNVs correlate with higher relative vGRF values during TLH and OLH in the landing phase.
Induction of Immune Tolerance in Islet Transplantation Using Apoptotic Donor Leukocytes
Authors: Sato Naoya , Marubashi Shigeru
Published: November 2021

Allogeneic islet transplantation has become an effective treatment option for severe Type 1 diabetes with intractable impaired awareness due to hypoglycemic events. Although current immunosuppressive protocols effectively prevent the acute rejection associated with initial T cell activation in recipients, chronic rejection has remained an obstacle for achieving long-term allogeneic islet engraftment. The development of donor-specific immune tolerance to the allograft is the ultimate goal given its potential ability to overcome chronic rejection and disregard the need for maintenance immunosuppression, which may be toxic to islet grafts. Recently, a breakthrough in tolerance induction during allogeneic islet transplantation using apoptotic donor lymphocytes (ADLs) in a non-human primate model had been reported. Several studies have suggested that the clonal depletion, anergy, and expansion of the antigen-specific regulatory immune network are the mechanisms for donor-specific tolerance with ADLs, which act synergistically to induce robust transplant tolerance. This achievement represents a huge step forward toward the clinical application of immune tolerance induction. We herein summarize the reported operational induction therapies in islet transplantation using the ADLs. Moreover, a few obstacles for the engraftment of transplanted islets, such as islet immunogenicity and instant blood-mediated response, which need to be resolved in the future, are also discussed.
Clinical Neurophysiology, Neuroimaging, and Neuromodulation of Neuropsychiatric Disorders
Authors: Noda Yoshihiro
Published: November 2021

The goal of this Special Issue is to introduce the cutting-edge research in clinical neurophysiology, neuroimaging, and neuromodulation [...]
Neoadjuvant Therapy Using Checkpoint Inhibitors before Radical Cystectomy for Muscle Invasive Bladder Cancer: A Systematic Review
Authors: SHSM Hadi , Fahmy Usama , Alhakamy Nabil , Khairul-Asri Mohd , Fahmy Omar
Published: November 2021

Background: Neoadjuvant chemotherapy is the standard of care before radical cystectomy for muscle invasive bladder cancer. Recently, checkpoint inhibitors have been investigated as a neoadjuvant treatment after the reported efficacy of checkpoint inhibitors in metastatic urothelial carcinoma. Objectives: The aim of this systematic review is to investigate the role of checkpoint inhibitors as a neoadjuvant treatment for muscle invasive bladder cancer before radical cystectomy. Methods: Based on the PRISMA statement, a systematic review of the literature was conducted through online databases and the American Society of Clinical Oncology (ASCO) Meeting Library. Suitable publications were subjected to full-text assessment. The primary outcome of this review was to identify the impact of neoadjuvant immunotherapy on the oncological outcomes and survival benefits. Results: From the retrieved 254 results, 8 studies including 404 patients were included. Complete response varied between 30% and 50%. Downstaging varied between 50% and 74%. ≥Grade 3 AEs were recorded in 8.6% of patients who received monotherapy with either Atezolizumab or Pembrolizumab. In patients who received combination treatment, the incidence of ≥Grade 3 AEs was 16.3% for chemoimmunotherapy and 36.5% for combined immunotherapy. A total of 373 patients (92%) underwent radical cystectomy. ≥Grade 3 Clavien-Dindo surgical complications were reported in 21.7% of the patients. One-year overall survival (OS) and relapse-free survival (RFS) varied between 81% and 92%, and 70% and 88%, respectively. Conclusion: The evidence on the use of immune checkpoint inhibitors in the setting of pre-radical cystectomy is quite limited, with noted variability within published trials. Combination with chemotherapy or another checkpoint inhibitor may boost response, although prospective studies with extended follow-up are needed to report on the survival advantages.
Comprehensive Overview of Vaccination during Pregnancy in Europe
Authors: Simionescu Anca Angela , Streinu-Cercel Anca , Popescu Florin-Dan , Stanescu Ana Maria Alexandra , Vieru Mariana , Danciu Bianca Mihaela , Miron Victor Daniel , Săndulescu Oana
Published: November 2021

Vaccinations during pregnancy can protect the mother from several infections, thus blocking vertical transmission. Furthermore, through passive antibody transfer, the newborn can be protected against some infections in the first months of life until their own vaccination regimen is initiated and completed at the appropriate age. Pregnancy can be considered a high-risk condition that increases vulnerability to infectious diseases with potentially unfavorable evolution. We present the current knowledge on vaccination during pregnancy in Europe as a useful information source for different health workers involved in prenatal care. Many European countries implement vaccination policies specifically designed for pregnant women, but there is great heterogeneity among programs. Recommendations on vaccination during pregnancy must be based on current high-quality scientific data. The decisions must be made for each individual case, depending on the associated conditions or special circumstances, with a concomitant assessment of the potential benefits and risks to both the pregnant patient and the fetus. Many vaccines are well-tolerated in pregnant women, with no clinically meaningful injection site reactions, systemic symptoms, or vaccine-related serious adverse events.
Diagnostic and Prognostic Value of Three microRNAs in Environmental Asbestiform Fibers-Associated Malignant Mesothelioma
Authors: Filetti Veronica , Loreto Carla , Falzone Luca , Lombardo Claudia , Cannizzaro Emanuele , Castorina Sergio , Ledda Caterina , Rapisarda Venerando
Published: November 2021

Fluoro-edenite (FE) is an asbestiform fiber identified in Biancavilla (Sicily, Italy). Environmental exposure to FE has been associated with a higher incidence of malignant mesothelioma (MM). The present study aimed to validate the predicted diagnostic significance of hsa-miR-323a-3p, hsa-miR-101-3p, and hsa-miR-20b-5p on a subset of MM patients exposed to FE and matched with healthy controls. For this purpose, MM tissues vs. nonmalignant pleura tissues were analyzed through droplet digital PCR (ddPCR) to evaluate differences in the expression levels of the selected miRNAs and their MM diagnostic potential. In addition, further computational analysis has been performed to establish the correlation of these miRNAs with the available online asbestos exposure data and clinic-pathological parameters to verify the potential role of these miRNAs as prognostic tools. ddPCR results showed that the three analyzed miRNAs were significantly down-regulated in MM cases vs. controls. Receiver operating characteristic (ROC) analysis revealed high specificity and sensitivity rates for both hsa-miR-323a-3p and hsa-miR-20b-5p, which thus acquire a diagnostic value for MM. In silico results showed a potential prognostic role of hsa-miR-101-3p due to a significant association of its higher expression and increased overall survival (OS) of MM patients.
Application of Harmony Search Algorithm to Slope Stability Analysis
Authors: Haghshenas Sina Shaffiee , Haghshenas Sami Shaffiee , Geem Zong Woo , Kim Tae-Hyung , Mikaeil Reza , Pugliese Luigi , Troncone Antonello
Published: November 2021

Slope stability analysis is undoubtedly one of the most complex problems in geotechnical engineering and its study plays a paramount role in mitigating the risk associated with the occurrence of a landslide. This problem is commonly tackled by using limit equilibrium methods or advanced numerical techniques to assess the slope safety factor or, sometimes, even the displacement field of the slope. In this study, as an alternative approach, an attempt to assess the stability condition of homogeneous slopes was made using a machine learning (ML) technique. Specifically, a meta-heuristic algorithm (Harmony Search (HS) algorithm) and K-means algorithm were employed to perform a clustering analysis by considering two different classes, depending on whether a slope was unstable or stable. To achieve the purpose of this study, a database made up of 19 case studies with 6 model inputs including unit weight, intercept cohesion, angle of shearing resistance, slope angle, slope height and pore pressure ratio and one output (i.e., the slope safety factor) was established. Referring to this database, 17 out of 19 slopes were categorized correctly. Moreover, the obtained results showed that, referring to the considered database, the intercept cohesion was the most significant parameter in defining the class of each slope, whereas the unit weight had the smallest influence. Finally, the obtained results showed that the Harmony Search algorithm is an efficient approach for training K-means algorithms.
Is Restorative Justice an Effective Approach in Responding to Children and Young People Who Sexually Harm?
Authors: Armstrong Lisa Mary
Published: November 2021

In the UK, Australia, and further afield, restorative programmes have been developed as a response to the failure of the criminal justice system to give victims of sexual violence a voice in the legal process. The restorative justice literature has tended to focus on sexual offences perpetrated by adults and the importance of being victim centred. When it is a child or young person (CYP) who sexually harms, it poses a unique set of challenges for law and society and the restorative practitioner. This article explores the reasons why a different approach may be warranted given the perceived failure of conventional criminal justice in addressing the growing problem of child and adolescent harmful sexual behaviour (HSB) in Scotland. It discusses the difficulties with balancing the rights of the victim with the CYP who perpetrates the HSB and considers the challenges encountered by practitioners in the implementation and application of restorative programmes in HSB cases involving CYP. Although the evidence supports a growing need for a different approach, and restorative justice may offer just that, problems with net widening, the referral process, and resistance from other professionals and victim advocacy groups present real barriers. Consequently, restorative practitioners are likely to find practising in this area more challenging due to a lack of support and cooperation.
Environmental, Ecological and Food Resources in the Biodiversity Overview: Health Benefits
Authors: Durazzo Alessandra , Lucarini Massimo
Published: November 2021

The Special Issue “Environmental, Ecological and Food Resources in the Biodiversity Overview: Health Benefits” wants to underline the importance of classification, cataloguing and analysis of environmental, agricultural, ecological, botanical and food sources—from native species to unconventional sources and wastes—which should be promoted from the perspectives of biodiversity and sustainability [...]
Sensitivity Analysis of Stochastic Calculation of SCC Regarding Aggressive Environment
Authors: Lehner Petr , Horňáková Marie , Hrabová Kristýna
Published: November 2021

Probabilistic procedures considering the durability with respect to corrosion of reinforcement caused by aggressive substances are widely applied; however, they are based on narrow assumptions. The aspects need to be evaluated both in terms of the search for suitable application of the various experimental results and in terms of their impact on the result of the stochastic assessment itself. In this article, sensitivity analysis was used as an ideal tool to prove how input parameters affect the results of the evaluation, with consideration of different types of concrete (ordinary or self-compacting with and without fibres). These concretes may be used in aggressive environments, as an industrial floor or as a part of the load-bearing bridge structure. An example of a reinforced concrete bridge deck was selected as the solved structure. The results show that in the case of a classic evaluation, a larger amount of fibre reports a lower resistance of concrete, which contradicts the assumptions. The sensitivity analysis then shows that self-compacting concrete is more sensitive to the values of the diffusion coefficient, and with the consideration of fibres, the effect is even greater.
Effect of Light-Sources and Thicknesses of Composite Onlays on Micro-Hardness of Luting Composites
Authors: De Angelis Francesco , Vadini Mirco , Capogreco Mario , D’Arcangelo Camillo , D’Amario Maurizio
Published: November 2021

The aim of this study was to compare three different light-curing-units (LCUs) and determine their effectiveness in the adhesive cementation of indirect composite restorations when a light-curing resin cement is used. Two resin composites were selected: Enamel Plus HRI (Micerium) and AURA (SDI). Three thicknesses (3 mm, 4 mm and 5 mm) were produced and applied as overlays and underlays for each resin composite. A standardized composite layer was placed between underlay and overlay surfaces. Light curing of the resin-based luting composites was attained through the overlay filters using LCUs for different exposure times. All specimens were allocated to experimental groups according to the overlay thickness, curing unit and curing time. Vickers Hardness (VH) notches were carried out on each specimen. Data were statistically evaluated. The curing unit, curing time and overlay thickness were significant factors capable of influencing VH values. The results showed significantly decreased VH values with increasing specimen thickness (p < 0.05). Significant differences in VH values were found amongst the LCUs for the various exposure times (p < 0.05). According to the results, a time of cure shorter than 80 s (with a conventional quartz–tungsten–halogen LCU) or shorter than 40 s (with a high-power light-emitting diode (LED) LCU) is not recommended. The only subgroup achieving clinically acceptable VH values after a short 20 s curing time included the 3 mm-thick overlays made out of the AURA composite, when the high-power LED LCU unit was used (VH 51.0). Composite thickness has an intense effect on polymerization. In clinical practice, light-cured resin cements may result in insufficient polymerization for high thickness and inadequate times. High-intensity curing lights can attain the sufficient polymerization of resin cements through overlays in a significantly shorter time than conventional halogen light.
Neurosurgical Approaches to Brain Tissue Harvesting for the Establishment of Cell Cultures in Neural Experimental Cell Models
Authors: Gradišnik Lidija , Bošnjak Roman , Bunc Gorazd , Ravnik Janez , Maver Tina , Velnar Tomaž
Published: November 2021

In recent decades, cell biology has made rapid progress. Cell isolation and cultivation techniques, supported by modern laboratory procedures and experimental capabilities, provide a wide range of opportunities for in vitro research to study physiological and pathophysiological processes in health and disease. They can also be used very efficiently for the analysis of biomaterials. Before a new biomaterial is ready for implantation into tissues and widespread use in clinical practice, it must be extensively tested. Experimental cell models, which are a suitable testing ground and the first line of empirical exploration of new biomaterials, must contain suitable cells that form the basis of biomaterial testing. To isolate a stable and suitable cell culture, many steps are required. The first and one of the most important steps is the collection of donor tissue, usually during a surgical procedure. Thus, the collection is the foundation for the success of cell isolation. This article explains the sources and neurosurgical procedures for obtaining brain tissue samples for cell isolation techniques, which are essential for biomaterial testing procedures.
Development of a High-Resolution Acoustic Sensor Based on ZnO Film Deposited by the RF Magnetron Sputtering Method
Authors: Kang Dong-Chan , Kim Jeong-Nyeon , Park Ik-Keun
Published: November 2021

In the study, an acoustic sensor for a high-resolution acoustic microscope was fabricated using zinc oxide (ZnO) piezoelectric ceramics. The c-cut sapphire was processed into a lens shape to deposit a ZnO film using radio frequency (RF) magnetron sputtering, and an upper and a lower electrode were deposited using E-beam evaporation. The electrode was a Au thin film, and a Ti thin film was used as an adhesion layer. The surface microstructure of the ZnO film was observed using a scanning electron microscope (SEM), the thickness of the film was measured using a focused ion beam (FIB) for piezoelectric ceramics deposited on the sapphire wafer, and the thickness of ZnO was measured to be 4.87 μm. As a result of analyzing the crystal growth plane using X-ray diffraction (XRD) analysis, it was confirmed that the piezoelectric characteristics were grown to the (0002) plane. The sensor fabricated in this study had a center frequency of 352 MHz. The bandwidth indicates the range of upper (375 MHz) and lower (328 MHz) frequencies at the −6 dB level of the center frequency. As a result of image analysis using the resolution chart, the resolution was about 1 μm.
Eluviation and Leaching of Elements from Broken Fly-Ash-Based Porous Geopolymer
Authors: Shi Peng , Zhang Yuan , Sun Qingfu , Ta Xupeng
Published: November 2021

The fly ash from powerplants used for coal mine end backfilling can effectively reduce the impact of ground fly ash accumulation on the environment. However, due to the long-term action of the overlying strata and groundwater, when the backfilling body is broken, heavy metals will also be leached, thus having an impact on the groundwater. Therefore, in this paper, the eluviation and leaching of elements from a broken fly-ash-based porous geopolymer is studied. The fly-ash-based geopolymer material was prepared to perform a dynamic eluviation and static leaching test, and it was found that the amount of Cu and Zn in the leachate was less abundant, whereas Pb was more abundant, but far less than the limit of the Class III groundwater quality standard. An acidic environment and a smaller solid–liquid ratio can promote the leaching of Cu and Zn, while the leaching of Pb is basically unaffected by the pH value. Moreover, the amount of Cu, Zn, and Pb in the lixivium increased with the increase in leaching time, and the amount of Cu and Zn in the lixivium was still low after 150 h of leaching, whereas the amount of Pb was high, approaching the limit value of the Class III groundwater quality standard, showing a tendency to increase after 100 h of leaching. A leaching orthogonal experiment was designed, and the results showed that the main order of each factor affecting the leaching of heavy metals from the fly-ash-based geopolymer was grain size > pH > solid–liquid ratio; thus, the leaching of heavy metals from fly-ash-based geopolymer can be controlled, which is significant with respect to the extensive use of fly-ash materials underground.
Flow Structure Investigations during Novec Refrigerant Condensation in Minichannels
Authors: Sikora Małgorzata
Published: November 2021

This article presents the results of flow visualization studies of Novec refrigerants during condensation in minichannels. Experimental investigation of two-phase flow regimes was conducted in minichannels with internal diameter dh = 2.5, 2.0, 1.2, and 0.5 mm. Images of the two-phase flow structures were analyzed by using the MATLAB algorithm. To calculate void fraction, a two-dimensional areal quantitative stereology technique was used. Observation of flow structures formed during the process of condensation was the major aim of the investigations. The condensation studies were conducted over a wide range of mass flux densities (G = 80–5500 kg/m2s) and saturation temperatures (ts = 30–70 °C). Visualization results and image analysis methods are described in this paper. Based on the experimental results, a flow structure map was constructed and presented.
Experimental Investigation and Thermodynamic Verification for the Phase Relation around the ε-Mg23 (Al, Zn)30 Intermetallic Compound in the Mg-Zn-Al System
Authors: Zheng Yan , Sun Jiaxing , Cheng Kaiming , Wang Jin , Zhan Chengwei , Zhao Jingrui , Wang Xitao , Tang Shouqiu , Zhou Jixue , Zhang Lijun , Du Yong
Published: November 2021

The appearance of the ε phase during the welding process can severely weaken the welding strength of dissimilar metals of Mg-Zn-Al alloy systems. An understanding of the accurate phase diagram, especially the equilibrium phase relation around the ε phase, is thus of particular importance. However, the phase interrelation near the ε-Mg23(Al, Zn)30 phase has not yet been fully studied. In this work, the local phase diagrams of the ε phase and its surrounding phases in the Mg-Zn-Al system are systematically determined by experimental investigation and thermodynamic verification. Five Mg-Zn-Al alloys and one diffusion couple were fabricated and analyzed to get accurate phase constituents and relationships adjacent to ε phase. The current experimental data obtained from Scanning Electron Microscope (SEM), X-ray diffraction (XRD), Differential Scanning Calorimetry (DSC), and Electron Probe Micro Analysis (EPMA) were further compared with the thermodynamically computed phase relations around ε phase for verification, showing good agreements. Several important conclusions are drawn based on current experimental work, which can provide supporting information for the follow-up studies on ε phase in the Mg-Zn-Al alloy systems.
Dynamic Modeling of a Front-Loading Type Washing Machine and Model Reliability Investigation
Authors: Park Jungjoon , Jeong Sinwoo , Yoo Honghee
Published: November 2021

A linear dynamic model of a front-loading type washing machine was developed in this study. The machine was conceptualized with three moving rigid bodies, revolute joints, springs, and dampers along with prescribed rotational drum motion. Kane’s method was employed for deriving the equations of motion of the idealized washing machine. Since the modal and transient characteristics can be conveniently investigated with a linear dynamic model, the linear model can be effectively used for the design of an FL type washing machine. Despite the convenience, however, the reliability of the linear dynamic model is often restricted to a certain range of system parameters. Parameters relevant to the reliability of the linear dynamic model were identified and the parameters’ ranges that could guarantee the reliability of the proposed linear dynamic model were numerically investigated in this study.
Mathematical and Simulation Model for Reliability Analysis of a Heterogeneous Redundant Data Transmission System
Authors: Houankpo Hector Gibson Kinmanhon , Kozyrev Dmitry
Published: November 2021

In the actual study, we carried out a reliability analysis of a repairable redundant data transmission system with the use of the elaborated mathematical and simulation model of a closed heterogeneous cold standby system. The system consists of one repair unit and two different data sources with an exponential cumulative distribution function (CDF) of their uptime and a general independent CDF of their repair time. We consider five special cases of the general independent CDF; including Gamma, Weibull-Gnedenko, Exponential, Lognormal and Pareto. We study the system-level reliability, defined as the steady-state probability (SSP) of failure-free system operation. The proposed analytical methodology made it possible to assess the reliability of the whole system in the event of failure of its components. Specific analytic expressions and asymptotic valuations are obtained for the steady-state probabilities of the system and the SSP of failure-free system operation. A simulation model of the system in cases where it is not workable to obtain expressions for the steady-state probabilities of the system in an explicit analytical form was considered, in particular for constructing the empirical system reliability function. The issue of sensitivity analysis of reliability characteristics of the considered system to the types of repair time distributions was also studied. The simulation modeling was done with the R statistics package.
Granule-Based-Classifier (GbC): A Lattice Computing Scheme Applied on Tree Data Structures
Authors: Kaburlasos Vassilis G. , Lytridis Chris , Vrochidou Eleni , Bazinas Christos , Papakostas George A. , Lekova Anna , Bouattane Omar , Youssfi Mohamed , Hashimoto Takashi
Published: November 2021

Social robots keep proliferating. A critical challenge remains their sensible interaction with humans, especially in real world applications. Hence, computing with real world semantics is instrumental. Recently, the Lattice Computing (LC) paradigm has been proposed with a capacity to compute with semantics represented by partial order in a mathematical lattice data domain. In the aforementioned context, this work proposes a parametric LC classifier, namely a Granule-based-Classifier (GbC), applicable in a mathematical lattice (T,⊑) of tree data structures, each of which represents a human face. A tree data structure here emerges from 68 facial landmarks (points) computed in a data preprocessing step by the OpenFace software. The proposed (tree) representation retains human anonymity during data processing. Extensive computational experiments regarding three different pattern recognition problems, namely (1) head orientation, (2) facial expressions, and (3) human face recognition, demonstrate GbC capacities, including good classification results, and a common human face representation in different pattern recognition problems, as well as data induced granular rules in (T,⊑) that allow for (a) explainable decision-making, (b) tunable generalization enabled also by formal logic/reasoning techniques, and (c) an inherent capacity for modular data fusion extensions. The potential of the proposed techniques is discussed.
Sequencing Batch Integrated Fixed-Film Activated Sludge Membrane Process for Treatment of Tapioca Processing Wastewater
Authors: Zainuddin Nur Izzati , Bilad Muhammad Roil , Marbelia Lisendra , Budhijanto Wiratni , Arahman Nasrul , Fahrina Afrilia , Shamsuddin Norazanita , Zaki Zaki Ismail , El-Bahy Zeinhom M. , Nandiyanto Asep Bayu Dani , Gunawan Poernomo
Published: November 2021

Tapioca processing industries are very popular in the rural community to produce a variety of foods as the end products. Due to their small scales and scattered locations, they require robust modular systems to operate at low capacity with minimum supervision. This study explores the application of a novel sequencing batch-integrated fixed-film activated sludge membrane (SB-IFASM) process to treat tapioca processing wastewater for reuse purposes. The SB-IFASM employed a gravity-driven system and utilizes biofilm to enhance biodegradation without requiring membrane cleaning. The SB-IFASM utilizes the biofilm as a secondary biodegradation stage to enhance the permeate quality applicable for reuse. A lab-scale SB-IFASM was developed, preliminarily assessed, and used to treat synthetic tapioca processing industry wastewater. The results of short-term filtration tests showed the significant impact of hydrostatic pressure on membrane compaction and instant cake layer formation. Increasing the pressure from 2.2 to 10 kPa lowered the permeability of clean water and activated sludge from 720 to 425 and from 110 to 50 L/m2·h bar, respectively. The unsteady-state operation of the SB-IFASM showed the prominent role of the bio-cake in removing the organics reaching the permeate quality suitable for reuse. High COD removals of 63–98% demonstrated the prominence contribution of the biofilm in enhancing biological performance and ultimate COD removals of >93% make it very attractive for application in small-scale tapioca processing industries. However, the biological ecosystem was unstable, as shown by foaming that deteriorated permeability and was detrimental to the organic removal. Further developments are still required, particularly to address the biological stability and low permeability.