bluuebunny/crossref_metadata_2025 huggingface dataset:
Glycan Masking and Colonization Assay v1
Authors: Parkinson John , Weis Lab OSU
Published: March 2018

Use this protocol to mask Symbiodinium cell surface glycans prior to colonizing aposymbioticExaiptasiapolyps, then measure colonization dynamics with epifluorescent microscopy.
Intestine cell dissociation v2
Authors: Potter Andrew
Published: March 2018

Protocol for human intestine cell dissociation.
EXPERIENCE OF USING SYNTHETIC PROSTHESES PROLIFT ® (GYNECARE) FOR CORRECTION OF GENITAL PROLAPSE
Authors: Levakov S A , Wanke N S , Shablovskiy O R , Kedrova A G , Shirshov V N , Wanke E S
Published: March 2018

The aim was to evaluated anatomical and symptom specific outcome measures of prolapse repair with PROLIFT ® (Gynecare). In this longitudinal prospective observational study we collected data on a total of 85 women with pelvic organ prolapse stage 2 or more. Objective success rate was 85.9% at 6 months respectively. Patients required a blood more 500 ml - 7,1% and need transfusion. The mesh erosion rate or the displacement of the mesh were 3,5%. Vaginal surgery with prolift mesh® is an effective and safe procedure to correct pelvic organ prolapse over one year follow up.
POSSIBILITY OF ULTRASOUND METHODSNTO DETERMINE THE TACTICS OF TREATMENT FOR STRESS URINARY INCONTINENCE IN WOMEN WITH VAGINAL PROLAPSE
Authors: Shirshov V N , Levakov S A , Nechaeva O E , Krutova T V , Obolonkov V Y
Published: March 2018

Stress urinary incontinence is an actual medical and social problem and involves more than 30% women in developed countries spoiling quality of life. Ultrasonic sings of urethra and bladder changes revealed in 136 women with urinary incontinence and slight anterior vaginal fornix prolapse are analyzed in the article. 67 women were treated conservatively and the rest of them survived surgery: sling or pelvic prolift or their combination. The choice of treatment method was based on ultrasonic data. Clinical efficacy was 100% in both groups. The results showed ultrasonic data to be informative for revealing low urinary tract changes in women with urinary incontinence and useful for treatment method choice.
SYNTHETIC INOSINE ANALOGS IN TREATMENT OF CIN IIII
Authors: Levakov S A , Kedrova A G , Kozhurina E V , Wanke N S
Published: March 2018

Genes products of human papillomavirus (HPV) have been identified in more then 99,7% of cervical carcinomas. Several factors may be associated with higher rates of surgical treatment failure, including highgrade CIN, large lesion size, satellite HPVrelated lesions, involved margin, persistent HPV infection. Several pharmaceutical analogs of inosine have been using about 40 years to treat broad spectrum of viral infections. Clinical and experimental studies concerning efficacy and molecular mechanism of Inosine pranobeх are characterized this product as a safe and natural immune stimulating agent with beneficial results in patients with HPV. The purpose of the study is to evaluate the effect and toxicity of the antivirus therapy of Inosine pranobeх in the complex treatment of HPV infected patients affected CIN, CC in situ and recurrence of CIN in HPVpositive women after loop conization. Surgery with the antivirus therapy of Inosine pranobeх exhibited a protective effect on the recurrence of any CIN. Inosine pranobeх is characterized as a natural immune stimulating agent without pleiotropic effects of cytokines. Our data and global clinical studies have confirmed the safety and efficacy in the treatment of CIN Inosine pranobex.
COMPARISON RESULTS OF SURGICAL TREATMENT LOCALIZED AND EXTENDED UTERINE CANCER
Authors: Ushakov I I , Artoshina E A , Brousov P G , Nazvantsev I V , Levakov S A , Kedrova A G
Published: March 2018

We selected 145 patients with endometrial carcinoma who had been treated with standard surgery (hysterectomy and BSO, peritoneal washing, palpation pelvic and para-aortic nodes) and with complete systematic pelvic lymphadenectomy (n=30 patients) or combined pelvic and para-aortic lymphadenectomy (n=30). Patients at intermediate or high risk of recurrence were offered adjuvant radiotherapy. The primary outcome measure was results of the surgical therapy.
MODERN TRENDS TO LAPAROSCOPIC SURGERY IN GYNECOLOGY
Authors: Levakov S A , Kedrova A G , Wanke N S
Published: March 2018

Gynecologic laparoscopy has evolved from a limited surgical procedure used only for diagnosis and tubal ligations to a major surgical tool used to treat a multitude of gynecologic indications. Today, laparoscopy is one of the most common surgical procedures performed by gynecologists. The review presents the main trends of development of modern surgery in gynecology with the author's personal views on the key contentious issues of endoscopic sinus surgery.
ANEMIA AND INTERSTICIAL PNEUMONIA AS SYSTEM MANIFESTATIONS OF RHEUMATOID ARTHRITIS: THE CASE REPORT
Authors: Sajkovsky R S , Verhotin A A , Chigirina Y A , Antonova E A , Lesnyak V N
Published: March 2018

The short literature review of the problem of anemia and lung lesions as a systemic manifestations of rheumatoid arthritis (RA) are presented. The anemia as a chronic disease occurs in RA patients most frequently, the mechanisms of its development are presented. The description of the variants of the lung lesions is performed. There is the description of the patient case report, has suffered from RA with such main clinical manifestations as anemia and interstitial pneumonia.
EARLY CONTINENCE RECOVERY IN PATIENTS WITH RADICAL PROSTATECTOMY
Authors: Perepechay V A , Dmitriadi S N , Alekseev B Y
Published: March 2018

From 2008 to July 2010 95 patients underwent radical prostatectomy (RP) – 12 of them – laparoscopic prostatectomy, 83 – retropubic prostatectomy. In 43 patients suspension of urethral anastomosis was not performed. 11 patients underwent the Noguchi's front suspension (11,6%), 22 patients – Tewari's complete reconstruction of the fascial structures (23,1%) and 19 – complete reconstruction of the fascial structures with a modified technique of the rear suspension with a deficit of length of aponeurosis Denonvile (20%). Monitoring of continence was conducted on the third day of the removal of the catheter, in 1 month, 3 months, 6 months and 1 year. 74.7% of patients evaluated in a period of 6 months and only 54,7% of patients – in a year after surgery. On third day of removal of the catheter continence in a group without complete suspension was 20,9%, with front suspension – 27,3% in the group with Tewari's reconstruction – 49,9%, with Denonvile suspension – 36,8% respectively. 1month continence was 36,6%, 54,5%, 76,2% 78,9% respectively. Through threemonth observation full time continence was achieved in 63,8%, 60%, 85,7% and 73,3% respectively. Through 6 months and 12 months observation there was no significant difference in continence in all groups.
IMMUNOTROPIC AGENTS IN COMPLEX TREATMENT OF CHILDREN WITH INTERMITTENT ALLERGIC RHINITIS AND RECURRENT RESPIRATORY INFECTIONS
Authors: Chigaeva E V , Grankina N E
Published: March 2018

The purpose of the research was to develop a prescribing of immunomodulators Imudon, Viferon, Superlymph in the complex treatment of frequently ill children (FIC) with a frequency of ARI 6 or more times a year, foci of chronic infection in oro and nasopharynx, and intermittent (seasonal) AR mild or moderate severity (SAR). Methods: 120 FIC from 5 to 7 years old (56 boys and 64 girls) were followedup during 2 years. Investigation revealed pollen and household allergens predomination in the spectrum of causesignificant allergens. Microbial landscape of chronic infection foci in the oro and nasopharynx was characterized by a predominance of Staphylococcus aureus in 71,2%, Candida albicans in 28,8%, Streptococcus haemolyticus in 50% of patients. In 67.4% of patients microbial associations of 2 and 3 pathogens predominated. Immune system abnormalities were characterized by reduction in T cells, the level of serum IgA in 62.5%, gammaIFN – in 80%, alphainterferon – a 60% increase in serum IgG – at 62,5%, TNFα – 80,0%, and IgE – in 100% of the children. Supplementation of Imudon, Superlymph and Viferon as a component of complex treatment of this category of children reduces the mucous contamination with active forms of Candida albicans by 24 times, with bacterial flora ( Staphylococcus aureus, Streptococcus spp. ) in 2 3,4 times, reduces inflammation of the mucous membranes of oro and nasopharynx, adenoid hypertrophy, reduces the frequency of ARI in 1,9, 2,5 and 3,1 times respectively. In 16,6% of FIC with SAR who did not receive immunomodulators in complex treatment, persistent AR developed in a year of observation. Cases of persistent AR in groups of children receiving Superlymph or Viferon were not revealed.
EPIDEMIOLOGICAL CHARACTERISTICS OF CHRONIC HEART FAILURE PATIENTS IN ROSTOV REGION
Authors: Dorofeeva N P , Pleskachev S A , Shlyk S V , Tchigaeva E V , TherAnanyanz E A , Mashtalova O G , Koulikova I E , Pleskachev A S
Published: March 2018

Objective. Assesment of chronic heart failure (CHF) prevalence and differential treatment in Rostov Region based on retrospective and prospective evaluation. Materials and methods. Retrospective analysis of 3059 casehistories of CHF patients hospitalized in cardiology departments of Rostov Region in 2008. 745 patients prospective followup. Results. Inpatients demonstrate a 52% CHF prevalence with a mortality rate of 3%. Major CHF development factors (in 82% cases) were determined to be ischaemic heart disease and arterial hypertension. Optimal medical treatment with basic pharmacological groups of drugs was conducted in 82% of inpatients the number decreasing to 53% during a year after discharge.
ТHE DIAGNOSIS OF ARTICULATE SURFACE CHANGES OF COXOFEMORAL JOINT IN COXARTHROSIS PATIENTS BY SPIRAL COMPUTER TOMOGRAPHY
Authors: Kolesnik A I , Piskunov I S , Borozenec F M , Simagov V I , Sizych S G , Plakhotina N A , Solodilov I M , Andrianov V A , Mochamed F L
Published: March 2018

The objective was to study changes of an articulate surface (AS) of coxofemoral joints (CFJ) at patients with osteoarthrosis (OА), using СТ Methods. The group of patients (92 joints), suffering bilateral OА 2nd and 3rd radiological stage was tested by СТ. The width of AS in front, anteromedial, posterolateral, back sides was measured; thus joints of all patients have been preliminary divided in two groups: group (A) with uniform narrowing of an articulate surface and group (B) with nonuniform narrowing AS. Comparison of sizes and areas of joint space in different parts was performed.
FUNCTIONAL STATUS OF ERECTILE COMPONENT IN PATIENTS WITH CHRONIC PROSTATITIS
Authors: Tereshin A T , Sosnowski I B
Published: March 2018

The paper presents research data on the functional assessment erectile dysfunction in middleaged men with chronic prostatitis. Identified singns indicate significant effects of chronic prostatitis on erectile disorder
PREVALENCE OF PROBLEM DRINKING AND ALCOHOL RELATED PROBLEMS AMONG TEAM SPORTS PLAYERS
Authors: Medvedev S A , Zverev Yu P
Published: March 2018

The aim of the present study was to assess the reasons and the pattern of alcohol consumption and the prevalence of alcohol related problems among professional soccer and basketball players. Psychometric instrument included Russian version of "AUDIT". The results demonstrated presence of significant alcoholization of sportsmen, which was reflected in the absence of responders abstaining from alcohol, preference for strong alcoholic beverages, high mean "AUDIT" score (7,4 ± 3,1) and alcohol consumption (401,7 ± 271,2 ml of ethanol per month). About one third of sportsmen consumed alcohol at dangerous level. The typical pattern of alcohol consumption was characterized by frequent intake of alcohol and consumption of 5 and more drinks on a typical day of drinking. About 93% of athletes experienced alcohol related problems.
APPLICATION OF INTEGRATED PROPRIOCEPTIVE CORRECTION IN MOTOR RECOVERY IN PATIENTS WITH STROKE
Authors: Shvarkov S B , Titova E U , Mizieva Z M , Matveeva O S , Bobrovskaya A N
Published: March 2018

We assessed the application of the proprioceptive correction method supporting stimulating foot massage "PIONt" and pull-suit "Regent" in medical rehabilitation of patients underwent spinal or cerebral strokes. The analysis of the neurological deficiency dynamics was performed; effectiveness of the neuro-rehabilitation predictors and mechanisms of proprioceptive correction method action were discussed. The significance of proprioceptive correction methods in a comprehensive restoration of neurologic function in stroke patients was shown.
MULTIDISCIPLINARY TEAM VALUE IN RECOVERY TREATMENT OF PATIENTS WITH CEREBROVASCULAR DISEASES
Authors: Shirshova E V
Published: March 2018

The results of a comprehensive clinical examination of 418 patients with various manifestations of cerebrovascular diseases (CVD) are analyzed. From the standpoint of functional disorders the analysis identified clinical manifestations CVD was performed and clarified their influence on the restriction of the fundamental types of activity. Multidisciplinary approach in restorative treatment and rehabilitation of patients with CVD is justified.
CASE HISTORY OF SUCCESSFUL TREATMENT BY PERMANENT ELECTROSTIMULATION OF THE SACRAL PLEXUSFOR NEUROGENIC CHRONIC PELVIC PAIN
Authors: Safin A V , Bobrovskaja A N , Isagulan E D , Durov O V , Larin A I
Published: March 2018

The chronic pelvic pain in women is a problem more often is being discussed by gynecologists and urologists. In the neurological practice pelvic pain occur quite rarely. Conservative treatment of chronic pelvic pain is little effective. The case history of successful relief of chronic neurogenic pelvis pain using a permanent electrostimulation of the sacral plexus is described.
CONGENITAL DIAPHRAGMATIC HERNIAS IN ADULTS
Authors: Zvezdkina E A , Lesnyak V N , Belov M A , Briginevich T A
Published: March 2018

Congenital diaphragmatic hernias are generally appearing in childhood, but are also occasionally detected in asymptomatic adult patients. Computed tomography is used for the correct diagnosis the hernia type and for its localization, facilitating its management and the choice of treatment. We report the case of parasternal diaphragmatic hernia of Morgagni-Larrey and two cases of posteriolateral Bochdalek diaphragmatic hernia. The patients showed no symptoms and were not surgically treated.
CHARACTRISTICS OF CYTOKINES, PHENOTIPIC FEATURES AND NEUTROPHILSPHAGOCYTOSIS ACTIVITY IN ASTHMATIC PATIENTS DURING EXACERBATION
Authors: Borisova T V , Sokurenko S I , Karaulov A V
Published: March 2018

The aim of our study was to measure the level of IL -8, IL-6, IL-4, IL-17 depending on spontaneous or induced release by peripheral blood leukocytes in patients with bronchial asthma exacerbation with comparative analysis of asthmatics' blood neutrophils phenotypic features. The obtained data indicate that the level either pro-inflammatory or anti-inflammatory cytokines was increased in patients with asthma exacerbations and significant increase of concentration of CD45+CD66b+CD11b+ cells in comparing with healthy donors. We determined that during asthma exacerbation the concentration of CD45+, CD66b+, CD11b+ blood granulocytes almost doubled in comparing with healthy donors. Also there is a significant increasing of blood granulocytes' phagocytosis activity. We observed the elevated level of spontaneous production of inflammatory mediators. Moreover, the stimulation of cytokines synthesis and release in patients with asthma does not always lead to increase of induced level of cytokines in contrast to healthy donors.
TRANSPLANTATION OF GENETIC MODIFIED STEM CELLS OVEREXPRESSING THERAPEUTIC GROWTH FACTORSFOR THE TREATMENT OF EXPERIMENTAL RAT MYOCARDIAL INFARCTION
Authors: Konoplyannikov M Anatol'evich , Haider K Kh , Ashraf M
Published: March 2018

We tested the hypothesis that simultaneous transgenic overexpression of a select quartet of growth factors activates diverse signaling pathways for mobilization and participation of various stem/progenitor cells for cardiogenesis in the infarcted heart. IGF-1, VEGF, SDF-1α, and HGF plasmids were synthesized and transfected into rat skeletal myoblasts (SM). Overexpression of growth factors in transfected SM (TransSM) was confirmed by reverse transcription PCR, western blotting, and fluorescence immunostaining. The conditioned medium (CM) from TransSM was cytoprotective for cardiomyocytes following H 2O 2 treatment, promoted a higher transwell migration of HUVEC cells and in vitro tube formation. Intramyocardial transplantation of 1.5×10 6 TransSM in a rat model of acute myocardial infarction induced extensive mobilization of stem/progenitor cells into the infarcted heart on day 7 and improved integration of TransSM in the heart compared to NatSM. Extensive neomyogenesis and angiogenesis with resultant attenuation of infarct size and improvement in global heart function was observed at 8 weeks. In conclusion, simultaneous activation of diverse signaling pathways by overexpression of multiple growth factors caused massive mobilization and homing of stem/progenitor cells from peripheral circulation, the bone marrow, and the heart for accelerated repair of the infarcted myocardium.
THE EFFECTIVENESS OF SPHEROGEL IN THE TREATMENT OF KNEE OSTEOARTHRITIS
Authors: Saykovskiy R S , Savenkova N A , Averyanov A V , Lisitsa A V
Published: March 2018

The resuts of randomized, double-blind, placebo-controlled, prospective trial in parallel groups of evaluation the efficiency safety and tolerability threefold (once a week) intraarticular injection of Spherogel are discussed in the study. It is estimated of positive effect of this medication to simptoms of gonarthritis: reducing of pain and improvement of functional activity of joint with a good tolerability. This effect continuos for least 3 month.
MODERN CONTROLLED MINIINVASIVE TECHNIQUES OF ACUTE DESTRUCTIVE PANCREATITIS DIAGNOSTIC AND TREATMENT
Authors: Borsukov A V , Mamoshin A V , Alechnovich A V
Published: March 2018

In the article the modern controlled miniinvasive techniques of acute destructive pancreatitis diagnostic and treatment and its complications are discussed. Perspective miniinvasive techniques as many-frequent bioimpedancometry and crystallography are described. Different controlled mini- invasive interventions were used in the particular sequence in dependence on clinico-morphological form of pathological process. Endocavital ultrasound research is considered as perspective area in the development of miniinvasive techniques of destructive pancreatitis treatment.
CORRECTION OF ENDOTHELIAL DYSFUNCTION IN PATIENTS WITH TERMINAL RENAL INSUFFICIENCY
Authors: Fedoseev A N , Vaulina A S , Smirnov V V , Ovsyannikov K V
Published: March 2018

The problem of development of endothelial disfunction in patients with end-stage renal failure and possibilities of its correction in extracorporal and medical methods is discussed.In research took part 60 patients with chronic kidney disease stage V by K/DOQI, which was evaluated vasomotor endothelial function in samples with reactive hyperemia and nitroglycerin, with simultaneous detection of the concentration of endothelin-1. The study confirmed the expressed changes of indicators vasodilating activity of the vascular wall and raising of endothelin-1 level in patients of this group. Effective method of correction of endothelial disfunction in patients with terminal renal insufficiency was early initiation of haemodyalisis therapy in combination with ACE inhibitors pharmacotherapy.
INTERVENTIONAL TREATMENT OF CORONARY HEART DISEASEIN PREVENTION OF SUDDEN CARDIAC DEATH
Authors: Staferov A V , Sorokin A V
Published: March 2018

Sudden cardiac death - a non-violent death, which developed instantly or within one hour from the time of acute changes in the clinical status of patient, which is based on cardiac causes. The main cause of SCD is coronary heart disease, which accounts for 80% of all cases. More than half of that cases are associated with acute disorders of the coronary circulation. Sudden cardiac death is a leading cause of mortality in patients with coronary artery disease. All activities that improve the prognosis in patients with coronary artery disease, reduce the risk of sudden cardiac death. Methods of direct myocardial revascularization allowed to improve radically the quality of life and prognosis in patients with coronary artery disease. Interventional treatment is highly effective and widely used method of direct myocardial revascularization, plays a crucial role in improving life expectancy of patients with ischemic heart disease, including through the prevention of sudden cardiac death.
SUDDEN CARDIAC DEATH PREVENTION FOR PATIENTS WITH ARRHYTHMOGENIC DYSPLASIA/CARDIOMYOPATHY OF RIGHT VENTRICLE
Authors: Yashin S M
Published: March 2018

The recent data of sudden cardiac death prevention for patients with arrhythmogenic dysplasia/cardiomyopathy of right ventricle are presented. Appropriate algorithm of threatment in different groups is also discussed.
PERSISTANT LEFT SUPERIOR VENA CAVA IN A PATIENT WITH AN IMPLANTED DUAL CHAMBERPASING SYSTEM
Authors: Kocharyan A A , Ovchinnikov R S , Lesniak V N , Ardashev A V
Published: March 2018

We described a clinical case of a 65-years patient with sick sinus syndrome with persistant left superior vena cava, whom was implanted dual chamber pacemaker.
GAIT ANALYSIS AT PATIENTS WITH ANTERIOR CRUCIATE LIGAMENT RUPTURE BEFORE AND AFTER SURGICAL TREATMENT
Authors: Akhpashev A A , Zagorodny N V , Kaurkin S N , Skvortsov D V
Published: March 2018

The anterior cruciate ligament (ACL) is most often structures to be damaged. In this research investigated biomechanics of walking at the timing, kinematics and dynamics parameters for 34 patients which had verified rupture of ACL. The 11 patients were investigated before surgical treatment and 23 after it. Investigations of patients of the first group were made at the time of 1 week to 6 years after trauma of the knee joint (the average meaning is 18 months). The second group was investigated at the time from 1,5 month to 5,5 years (the average meaning is 13 months).At the current research we did not find any specific for rupture of ACL functional disturbances during level walking compare to normal data and healthy limp. However, we assume some tendency to increase of flection-extention movement at the damaged knee joint after surgery.This result could give us some basis for revision the term of instability, because we did not get definite symptoms at our study.
A CASE OF RARE FORM OF PRIMARY CUTANEOUS CD4+ SMALL/MEDIUM T-CELL LYMPHOMA
Authors: Diakonov D A , Fedorovskaya N S , Luchinin A S
Published: March 2018

Primary cutaneous CD4+ small/medium T-cell lymphoma is very rare blood disease with usually good prognosis. However similar histology and immunohistоchemistry of this pathology with more aggressive T-cells lymphomas, such as mycosis fungoides, make it difficult for pathologist to find the accurate diagnosis. We report about of 40-year-old woman, whо came to our clinic with cheek skin lesion.
LARGE UTERINE LEIOMYOMAS: PATHOGENETIC MECHANISMS OF GROWTH
Authors: Kogan E A , Askolskaya S I , Popov Yu V , Solomakhina M A , Fayzullina N M
Published: March 2018

The pathogenesis of uterine fibroids remains controversial and raises many questions. The causes and mechanism of development of large leiomyoma are unknown. In the work the pathogenic mechanisms of large leiomyomas growth were estimated for different age groups.The research was based on studying of the expression of TGF-β, CD117, PD-ECGF, Ki67, connexin and nestin in postoperative material by comparing the clinical and morphological data. The most pronounced activity of growth areas, identified by molecular markers, was found in women over 45 years with LMMB-size, which requires the vigilance of cancer.
CURRENT STATE OF THE MALE INFERTILITY PROBLEM:THE REVIEW OF EUROPEAN ASSOCIATION OF UROLOGY CLINICAL GUIDELINES
Authors: Shirshov V N
Published: March 2018

The article highlights the problem of male infertility on the basis of review of the latest guidelines of European Association of urology
MINIINVASIVE TECHNIQUES OF ACUTE DESTRUCTIVE PANCREATITIS DIAGNOSTIC AND TREATMENT
Authors: Mamoshin A V , Borsukov A V , Ivanov Yu V , Istomin N P , Mokshina N V
Published: March 2018

In the article the modern controlled miniinvasive techniques of acute destructive pancreatitis diagnostic and treatment and its complications are discussed. Perspective miniinvasive techniques as many-frequent bioimpedancemetry and crystallography are described. Different controlled miniinvasive interventions were used in the particular sequence in dependence on clinico-morphological form of pathological process. Endocavital ultrasound research is the perspective area in the development of miniinvasive techniques at the destructive pancreatitis.
GRAFT LIGAMENTIZATION OF ANTERIOR CRUCIATE LIGAMENT
Authors: Akhpashev A A , Dzhambinova E A , Zvezdkina E A , Kanaev A S , Tkalin A N
Published: March 2018

The article presents an analysis of surgical treatment results of 71 patients, operated on for rupture of the anterior cruciate ligament (ACL) in the department of traumatology and orthopedics FSСС FMBA of Russia in 2013-2016. All patients underwent primary arthroscopic ACL reconstruction with autograft from tendons gracilis and semitendinosus. We assessed the condition of the operated knee joint on MRI after 3 - 6 - 12 - 24 months after surgery. Based on the criteria of MR studies, we concluded that the non-uniform diffuse change of MR signal from the graft on T2, PD FS can be traced in the first 2 years after surgery, reflecting process of ligamentization. In the first three months we also observed an increase in the diameter of the graft, which further regressed. Process of ligamentization ends within two years after the operation, whereby the signal from the MR-graft should be similar to the native ACL.
VASCULAR WALL CONDITION, GUT MICROBIOTA COMPOSITION, AND DIET IN PATIENTS WITHOUTCARDIOVASCULAR DISEASES
Authors: Kashtanova D A , Tkacheva O N , Egshatyan L V , Plokhova E V , Popenko A S , Tyakht A V , Alexeev D G , Kotovskaya Yu V , Boytsov S А
Published: March 2018

Purpose of the study. To study the relationship between the gut microbiota composition, the state of the vascular wall and nutrient intake in patients without clinical manifestation of cardiovascular disease.Materials and methods. The study included 92 residents from Moscow and the Moscow region, men and women aged 25 to 76 y.o., without clinical manifestations of chronic diseases, with no medical treatment but with possible presence of cardiovascular risk factors. All the participants were examined with duplex scanning of the carotid arteries with the definition of the thickness of the intima-media complex (IMC), the presence of atherosclerotic plaques, measuring carotid-femoral pulse wave velocity (PWV), the measurement of interleukin-6 (IL-6) and C-reactive protein (C-RP) and sequencing of the V3-V4 variable regions of 16S rRNA genes of the gut microbiota.Diet was studied by quantitative assessment of consumer products using a standardized computer program «Analysis of Human Nutrition states» (version 1.2.4 Research Institute of Nutrition 2003-2006).Results. The study revealed that in the investigated cohort IMC thickness was greater in those with a large number of bacterial genera Serratia and Blautia. Bifidobacterium representation was increased and Blautia representation was decreased in those who consumed a lot of starch.Conclusion. The composition of the gut microbiota is associated with both vascular wall stiffness and atherosclerosis. In addition, the bacteria associated with subclinical atherosclerosis were more represented among those who consumed smaller amounts of complex carbohydrates.
THE MODERN PROGRAMS OF COMPLEX EXAMINATION (CHECK-UP)
Authors: Motrich O G
Published: March 2018

In June 2015, in Federal research and clinical centre of FMBA of Russia was organized a new division: Check-up Clinic (complex diagnostic centre) the goal of which was to provide full medical examination in a short time and in a comfortable environment. About the specific features and future plans - our intervew with Head of Check-up Clinic.
ASSESSMENT of bIoresorbable Screws and bone tissue in long-term period after the anterior cruciate ligament reconstruction
Authors: Zvezdkina E A , Lesnyak V N , Akhpashev A A , Dzhambinova E A , Kanaev A S
Published: March 2018

The use of bioresorbable materials in the anterior cruciate ligament reconstruction is a promising direction. Thus today there is no single point of view on the long-term results of using absorbable interference screws. The article presents an analysis of the results of surgical treatment of 30 patients with use of bioresorbable materials, operated on for rupture of the anterior cruciate ligament (ACL) in the department of traumatology and orthopedics from 2010 to 2016 in the Federal Scientific Clinical Center FMBA of Russia. The aim of our study was to evaluate in vivo transformation of bioresorbable screws and bone assimilation into the tibial canal in long-term period after surgery, as well as the effect of the polymeric material and bone on these processes.
FROM IDIOPATHIC FIBROSING ALVEOLITIS TO IDIOPATIC LUNGS FIBROSIS
Authors: Averyanov A V , Lesnyak V N
Published: March 2018

The second part of the analytical review devoted to features of the clinical course and diagnosis of idiopathic pulmonary fibrosis. Special attention is paid to the specific CT symptoms allows diagnosis without lung biopsy. Current approaches to invasive diagnostics and perspectives of cryoprobe are discussed.
THE RESULTS OF INFORMATIONAL TECHNOLOGIES IMPLEMENTATION IN SOUTHERN REGIONAL MEDICAL CENTER FMBA OF RUSSIA
Authors: Gerasimov A E , Bessoltsev M A , Êorsunov L S
Published: March 2018

The article summarizes the results of the implementation in the Southern Regional Medical Center FMBA of Russia one of the directions of the Programme for modernization of the healthcare system - information technology. Considered the basic directions of the Programme implementation and methods for their realization.The conclusion is that the use of information technologies is absolutely necessary for fully-fledged activities of any medical organization.
THE RESULTS OF THE FIRST DECADE OF WORK IN THE SYSTEM OF FMBA OF RUSSIA. PROSPECTS AND ACHIEVEMENTS OF SOUTH REGIONAL MEDICAL CENTER
Authors: Krishtopin V S , Pleskachev S A , Osetrova I I
Published: March 2018

Thе article summarizes some results of work of the Southern Regional Medical Centre FMBA of Russia, analyses the results of the carried-out work for organizational structure improvement, restructuring of hospital bedspace and increasing the efficiency of treatment process. Examines the achieved indicators of access to health care, as well as forms and methods to enhance management skills of senior management. Much attention is paid to the basic directions of information technologies use in practical activities of medical organization.
HETEROTOPIC CONTINENT OR INCONTINENT URINARY DIVERSION:MAKING THE OPTIMAL CHOICE
Authors: Perepechay V A , Spitsyn I M , Vasilyev O N , Kogan M I
Published: March 2018

Introduction. Quality of life and survival rate of post-cystectomy patients depend on the urinary diversion methods [1,2].Purpose of the study. A comparison of morbidity, survival rate, and quality of life in patients after heterotopic continent or incontinent urinary diversions.Materials and methods. During the period from 1998 to 2016, 36 heterotopic intestinal diversions were performed using urine containment method according to the Kock pouch scheme in our modification, and 61 incontinent heterotopic intestinal Bricker diversions. We evaluated the comorbid conditions (Charlson comorbidity index), postoperative complications (acc. to Clavien-Dindo), survival rate (acc. to E.L. Kaplan, P. Meier), and the quality of life of patients (SF-36) using complex statistical analysis.Results. Early and late complications not related and related to urinary diversion prevailed in the group of patients after Bricker surgery without statistical significance. With longer postoperative monitoring periods the share of complications related to urinary diversion increases, while the frequency of delayed complications and survival rate show no statistical difference in both groups. No reliable differences were revealed in the quality of life in all cases of cutaneous urinary diversion.Discussion. 80% of patients after the Kock pouch surgery (mod.) throughout the medium follow-up period of over 5 years remain continent and enjoy high quality of life. It is necessary to develop and implement in clinical practice new and more advanced statistical tools for evaluation of the patients’ quality of life depending upon the type of urinary diversion after cystectomy.Conclusion. Heterotopic continent diversion (Kock pouch (mod.)) in comparison with the incontinent method (Bricker) does not increase morbidity or decrease the survival rate, and provides for higher quality of life.
POSSIBILITY OF COMPLEX LOCALIZATION INTRACRANIAL TUMORS HIGH-TECH MICRONEUROSURGERY WITH INITIALLY HIGH SURGICAL RISK
Authors: Airapetov K G
Published: March 2018

The combination of modern methods of functional and adequate sparing microneurosurgery and neuroanesthesia let successfully carry out the removal of intracranial tumors difficult localization, despite the high surgical risk, which increases the life expectancy of patients and improve their quality of life
FEATURES OF SENSORIMOTOR DISTURBANCES IN DIFFERENT PERIODS AFTER ISCHEMIC STROKE
Authors: Ekusheva E V , Kiparisova E S , Shirshova E V
Published: March 2018

The aim of the study was to investigate the clinical and neurophysiological features of sensorimotor disturbances in patients at different time periods after ischemic stroke. Methods. The study involved 133 patients with ischemic stroke in the right and left cerebral hemispheres in the late recovery (58) and residual (75) periods. There were 35 controls. Were performed transcranial magnetic stimulation, evoked abdominal reflexes and somatosensory evoked potentials. Results. It was shown that functional recovery processes are continuing with varying degrees of severity in patients and in a year after stroke. Conclusions. Persistence and severity of sensorimotor disturbances, as well as compensatory opportunities, defined afferent component of poststroke deficit, which implies an additional impact in this area to expand the possibilities of neurorehabilitation in patients after stroke.
PARTICULARITIES IN TREATMENT OF ESOPHAGEAL PERFORATION AFTER CERVICAL SPINE FUSION EXPERIENCE OF TREATMENT OF 24 PATIENTS
Authors: Pogodina A N , Green A A , Kasatkin D S , Kaikov A K , Lvov A S , Kordonskii A U , Shibaev E Y
Published: March 2018

The aim of the study is to specify the causes, peculiarities of the damage and the tactics of treating patients with clinically significant damages to the esophagus after the anterior cervical fusion or in combination with it.Material and methods: medical treatment of 24 patients in Sklifosovsky Emergency Research Institute with the damage to the esophagus after the front access surgery of the cervical spine during the period of 2003-2016 was analyzed.Results: we succeeded to restore or save the support ability of the spine for all patients and at the same time to take away the infected transplants, and, if necessary, to make adequate decompression of neurovascular entities of the spine column and fixation of the verbal-motor segment. 21 patients underwent conserving surgery in the cervical esophagus with its suturing with the double-row suture. 2 patients had failure of seams in the esophagus and they underwent a repeated surgery of suturing its defect. 2 patients underwent organodetrital surgeries. One patient died. Conclusion: damages to the esophagus after anterior cervical fusion or in combination with it are rare complications. That is why it is impossible to gain much experience in treating of such patients in only one clinic. In this case all publications on this topic are of great interest. Due to unsatisfactory results of the conservative therapy we should consider surgical treatment in general hospitals with the participation of a multidisciplinary brigade the golden standard.
REPEAT MYOCARDIAL REVASCULARIZATION IN LONG-TERM PERIOD AFTER PERCUTANEOUS CORONARY INTERVENTION IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE AND STABLE ANGINA PECTORIS
Authors: Zafiraki V K , Kosmacheva E D
Published: March 2018

Objective. To assess the effect of some characteristics of chronic obstructive pulmonary disease (COPD) in patients after elective percutaneous coronary intervention (PCI) on repeat myocardial revascularization frequency in long-term period (up to 3 year).Materials and methods. 135 patients with COPD, who suffered stable ischemic heart disease and were underwent PCI, were included in prospective observational study. Follow-up duration was up to3 year. Evaluation included comparing the frequency of elective repeat revascularization in regards to frequent COPD exacerbations, COPD severity, lung function and C-reactive protein (CRP) plasm level. Comparing Kaplan-Mayer curves and Cox regression analysis were also applied.Results. Elective repeat myocardial revascularization frequency was 23% and 2,1 times higher among the patients who had frequent COPD exacerbations history (95% CI 1,1-3,9). The difference between Kaplan-Mayers curves was also detected as statistically significant (p=0,016). None of the pulmonary function characteristics had relations with elective repeat revascularization frequency increase. Frequent COPD exacerbations history and CRP plasma level were included in Cox regression model as non-cardiovascular variables (p=0,05 and 0,08 respectively).Conclusions. Frequent COPD exacerbations history and increased CRP plasma level are indepen- dent non-cardiovascular variables related to increased risk of elective repeat myocardial revasculariza- tion. None of the pulmonary function characteristics had relations with elective repeat revasculariza- tion frequency increase.
NEUTROPHIL-LYMPHOCYTE RATIO AS A PREDICTOR OF ADVERSE IN PATIENTS WITH HEART FAILUREOF NONCORONAROGENIC ETIOLOGY
Authors: Bakhchoyan M R , Kosmacheva E D , Slavinsky A A
Published: March 2018

Aim of the study. To determine the prognostic significance of NLR ratio in patients with noncoronarogenic etiology HF during the hospital period and after hospital stay.Materials and methods. Totally, 75 patients were studied. LVEF<40%. The primary endpoint was a lethal outcome. Patients were divided into groups: 1) “dilated cardiomyopathy” (DCM) (n = 51); 2) “myocarditis” (n = 7); 3) “postmyocarditis cardiosclerosis” (n = 10); 4) “other” (n = 7). A general blood test was performed on the day of hospitalization and 7 days later. The long-term prognosis was analyzed according to the data of telephone contacts with patients, their relatives, outpatient cards.Results. A statistically significant relationship was established between NLR on the day of hospitalization and the overall mortality in the group “myocarditis” (NLR (%) = 2.23 + 0.78, p <0.05). NLR of the deceased in the group “DCM” was 3.98 + 0.60, which is significantly higher in comparison with the surviving patients in the same group (NLR 2.28 + 0.17, p<0.001). NLR was significantly decreased in all groups after 7 days (p<0.05 for the “DCM”, and NLR was practically comparable with the data of healthy people in the “PMCC”).Conclusions. The dynamic growth NLR of blood can serve as a predictor of death in patients suffering from DCM with LV EF<40%. NLR should be adopted for stratification of risk in this group of patients.
ASPECTS OF DETECTING PATIENTS WITH FAMILY HYPERCHOLESTEROLEMIA
Authors: Kurbanismailova P M , Popova A B , Dranenko N Yu , Sergienko I V
Published: March 2018

The review presents current data regarding the etiology and epidemiology of familial hypercholesterolemia (FH), algorithms for identifying patients with FH using clinical scales, genetic testing, cascade screening. The current tactics of treatment of family hypercholesterolemia, including in children and pregnant women, are given.
Conflict and Disease: A Complex Relationship
Authors: Frank Robert Alan
Published: March 2018

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Barriers to effective uptake of malaria prevention interventions in Ibadan, South West Nigeria: a qualitative study
Authors: Oladimeji Kelechi Elizabeth , Tsoka-Gwegweni Joyce Mahlako , Gengiah Santhanalakshmi , Daftary Amrita , Naidoo Kogieleum
Published: March 2018

Background: Although control measures have achieved considerable success, malaria is still a major public health problem in Nigeria and sub-Saharan Africa. The malaria burden is more among vulnerable groups like pregnant women and under-five aged children. This study explored barriers affecting uptake of current malaria prevention interventions in Ibadan, Southwest Nigeria.Methods: The study was conducted using qualitative research methods between May and August 2016 among community residents in Ibadan, Oyo state-Nigeria. Six focus group discussions (FGDs) and 16 in-depth interviews (IDI) were conducted with community members who were purposively selected and consented to participate in the study. The participants were grouped into six homogenous focus groups which included; pregnant women, mothers of under-five children, husbands, fathers, civil society members, and health staff such as hospital manager, nurses, pharmacist, medicine vendors, doctors, state program staff and national program staff. Data were transcribed, manually coded and analysed using content and thematic method. The Biomedical Research Ethics Committee (BREC), University of KwaZulu-Natal, South Africa and Oyo state Ministry of Health Ethics Committee, Nigeria both approved the study.Results: Knowledge on malaria causality and symptoms, prevention strategies, beliefs, fear of side effects from current malaria preventive measures, corruption and difficulty in obtaining nets, and poor environmental hygiene were some of the themes which emerged as barriers to the effective uptake of malaria prevention intervention.Conclusions: Strategies at the community level are urgently needed to address and improve within socio-cultural context uptake of current malaria prevention interventions.
When Saving Time becomes Labor: Time, Work, and Technology in Homecare
Authors: Bergschöld Jenny M.
Published: March 2018

The article shows how sociomaterial practices of ordering temporality can become part of labor and workers identities, when homecare workers who work with ‘time-saving’ technology experience a lack of sufficient time to do their work. The article offers the concept ‘time labour’ to describe this practice, and defines it as homecare workers methods of saving time, by cutting visits to care recipients as short as possible, and by using technology to strategically produce and maintain quantitative representations of themselves as skilled workers. The term time labor conceptualizes these methods as sociomaterial enactments of temporality that are an intrinsic part of the workers ability to perform that work as well as their ability to produce and maintain a professional identity. The article argues that the role of technology is never predictable, but always emerges in use, and suggests a turn toward domestication theory in practice theoretical studies of work with technology
A EDUCAÇÃO INTEGRAL NA PERSPECTIVA HISTÓRICO-CRÍTICA: PARA ALÉM DA AMPLIAÇÃO DO TEMPO ESCOLAR
Authors: Duarte Elaine Cristina Melo , Jacomeli Mara Regina Martins
Published: March 2018

As atuais políticas públicas de educação integral no Brasil partem da constatação de que os resultados escolares deixam a desejar, sendo necessário mais tempo para a realização de ações que revertam tal quadro. Mas as causas dessa situação são identificadas como externas ao âmbito propriamente pedagógico. O aumento do tempo escolar, ao invés de ser empregado em atividades que melhorem a aprendizagem dos conteúdos escolares, acaba sendo destinado a atividades que supostamente atacariam os problemas que impediriam o sucesso escolar, quais sejam: violência, “família desestruturada”, falta de interesse, ausência de perspectiva de vida etc. As escolas de tempo integral comumente realizam, no chamado contraturno, atividades desconectadas do ensino dos conteúdos escolares, com um caráter predominantemente recreativo e que, de certo modo, acabam prejudicando o estudo da criança, pois ela chega em casa cansada e não faz as tarefas escolares. Na perspectiva marxista da pedagogia histórico-crítica, esse tipo de educação em tempo integral não faz sentido, pois amplia o tempo de permanência da criança na escola, mas não garante o que proclama o discurso das políticas públicas, isto é, uma formação mais ampla e consequente melhoria da educação.

Palavras-chave: Educação Integral. Políticas públicas em educação. Pedagogia histórico-crítica. Marxismo.
La experiencia en la estética trascendental de Kant
Authors: Torres Adriana Rocio
Published: March 2018

La Crítica de la razón pura, tiene un propósito que es anunciado desde el comienzo, este propósito es la fundamentación de la metafísica como ciencia. En esta búsqueda aparece uno de los elementos que le van a servir a Kant para mostrar la posibilidad o la imposibilidad de este propósito, este elemento es la experiencia, punto central en la reflexión filosófica de la modernidad. El autor de la Crítica establece una nueva significación de la experiencia cuando expresa, que aunque todo conocimiento comience con ésta no todo procede de ella. Por un lado, la experiencia será un criterio para mostrar la objetividad del conocimiento y, por otro, se establecerán las condiciones puras de las que ésta depende, para que no quede reducida a lo contingente y a lo relativo. Es así como Kant propone la revolución copernicana, desde la necesidad de trasformar el método de la metafísica como lo han hecho conocimientos tales como, la matemática y la física y así encontrar el camino seguro de la ciencia. En esa búsqueda de un nuevo método para la metafísica aparece una de las primeras consideraciones acerca de la experiencia, que le servirán de punto de arranque para desarrollar sus demás consideraciones acerca de ésta.
Cárcel, poder y fragmentación en Saint Michel, de Gabriela Aguilera
Authors: Rodríguez Romero Nana
Published: March 2018

Presenta un estudio acerca de la obra Saint Michel novela fragmentada de la escritora chilena Gabriela Aguilera, que narra de manera fragmentada la cotidianidad de un grupo de homosexuales convictos en una cárcel. Se identifican las formas del poder relacionado con los dispositivos de control que circulan en las cárceles ylas relaciones de poder que se ejercen, a través de las teorías de Michel Foucault relacionadas con el concepto de poder, sus estrategias, y la presencia de la resistencia como un componente esencial.
Fen Bilgisi Öğretmen Adaylarının Lisansüstü Eğitime Yönelik Tutumlarının İncelenmesi
Authors: DEMİR Meryem , BEŞOLUK Şenol
Published: March 2018

Bu çalışmanın amacı, fen bilgisi öğretmen adaylarının lisansüstü eğitime ilişkin tutumlarının cinsiyet, mezun olunan lise türü, aile gelir durumu, sınıf düzeyi, anne ve babanın öğrenim durumu değişkenleri açısından incelenmesidir. Çalışmanın örneklemini 2016-2017 akademik yılında iki farklı devlet üniversitesinden uygun örnekleme yöntemi ile seçilmiş Fen Bilgisi Eğitimi Ana Bilim Dalı’nda öğrenim görmekte olan 201 kadın, 34 erkek olmak üzere toplam 235 fen bilgisi öğretmen adayı oluşturmaktadır. Çalışmanın örnekleminin belirlenmesinde uygun örnekleme yöntemi kullanılmıştır. Çalışmada nicel araştırma yöntemlerinden tarama yöntemi kullanılmıştır. Araştırmada veri toplama aracı olarak 30 maddeden oluşan Lisansüstü Eğitime İlişkin Tutum Ölçeği (İzgi, 2016) kullanılmıştır. Araştırma verileri kişisel bilgi formunun ve lisansüstü eğitime yönelik tutum ölçeğinin fen bilgisi öğretmen adaylarına uygulanması sonucunda toplanmıştır. İstatistiksel analizler uygulanmış ve bulgulara ulaşılmıştır. Araştırma sonucunda fen bilgisi öğretmen adaylarının lisansüstü eğitime yönelik tutumlarının yüksek olduğu görülmüştür. Araştırılan değişkenler arasında anlamlı farklılık görülmemiştir.