bluuebunny/crossref_metadata_2025 huggingface dataset:
Water Uptake and Hormone Modulation Responses to Nitrogen Supply in Populus simonii under PEG-Induced Drought Stress
Authors: Li Zhen , Wang Xiaoling , Liu Yunshan , Zhou Yangyan , Qian Zhiliang , Yu Zequn , Wu Na , Bian Zhan
Published: June 2022

In the present study, the effects of nitrogen (N) supply on water uptake, drought resistance, and hormone regulation were investigated in Populus simonii seedlings grown in hydroponic solution with 5% polyethylene glycol (PEG)-induced drought stress. While acclimating to drought, the P. simonii seedlings exhibited a reduction in growth; differential expression levels of aquaporins (AQPs); activation of auxin (IAA) and abscisic acid (ABA) signaling pathways; a decrease in the net photosynthetic rate and transpiration rate; and an increase in stable nitrogen isotope composition (δ15N), total soluble substances, and intrinsic water use efficiency (WUEi), with a shift in the homeostasis of reactive oxygen species (ROS) production and scavenging. A low N supply (0.01 mM NH4NO3) or sufficient N supply (1 mM NH4NO3) exhibited distinct morphological, physiological, and transcriptional responses during acclimation to drought, primarily due to strong responses in the transcriptional regulation of genes encoding AQPs; higher soluble phenolics, total N concentrations, and ROS scavenging; and lower transpiration rates, IAA content, ABA content, and ROS accumulation with a sufficient N supply. P. simonii can differentially manage water uptake and hormone modulation in response to drought stress under deficient and sufficient N conditions. These results suggested that increased N may contribute to drought tolerance by decreasing the transpiration rate and O2− production while increasing water uptake and antioxidant enzyme activity.
Drivers of Flammability of Eucalyptus globulus Labill Leaves: Terpenes, Essential Oils, and Moisture Content
Authors: Guerrero Fabián , Carmona Camilo , Hernández Carla , Toledo Mario , Arriagada Andrés , Espinoza Lorena , Bergmann Jan , Taborga Lautaro , Yañez Karen , Carrasco Yulián , Muñoz Ariel A.
Published: June 2022

Mediterranean climate regions have become more vulnerable to fire due to the extreme weather conditions and numerous Eucalyptus globulus plantation areas. The aim of this study is to analyze the fire hazard related to E. globulus in a forest fire scenario, based on the contrast of thermochemical parameters and their relationship with chemical properties, considering the predominant exotic forest species (E. globulus, Pinus radiata, Acacia dealbata, and Acacia melanoxylon) present in the Valparaiso region, Chile. The results revealed that although all of the studied species were highly flammable, E. globulus was extremely flammable, as its leaves contain high concentrations of essential oils, monoterpenes, and sesquiterpenes, which can generate a flammable atmosphere due to their low flashpoint and the strong negative influence shown between the essential oils, volatile terpenes, and limonene concentration. Moreover, the heat of combustion of E. globulus was positively correlated with its high essential oil contents. Finally, all of the studied species had low flashpoints and high heating values; therefore, they are predisposed to ignite in the presence of a heat source, releasing high amounts of energy during combustion, which contributes to the risk of the formation and spread of canopy fires among these tree formations.
Overview of Blockchain Oracle Research
Authors: Caldarelli Giulio
Published: June 2022

Whereas the use of distributed ledger technologies has previously been limited to cryptocurrencies, other sectors—such as healthcare, supply chain, and finance—can now benefit from them because of bitcoin scripts and smart contracts. However, these applications rely on oracles to fetch data from the real world, which cannot reproduce the trustless environment provided by blockchain networks. Despite their crucial role, academic research on blockchain oracles is still in its infancy, with few contributions and a heterogeneous approach. This study undertakes a bibliometric analysis by highlighting institutions and authors that are actively contributing to the oracle literature. Investigating blockchain oracle research state of the art, research themes, research directions, and converging studies will also be highlighted to discuss, on the one hand, current advancements in the field and, on the other hand, areas that require more investigation. The results also show that although worldwide collaboration is still lacking, various authors and institutions have been working in similar directions.
Short-Term Vegetation Response to Bulldozed Fire Lines in Northern Great Plains Grasslands
Authors: Tulganyam Samdanjigmed , Carr Craig A.
Published: June 2022

A bulldozed fire line is a fire-suppression technique that limits fire movement by altering fuel continuity through vegetation removal and mineral soil exposure. The ecological impacts of a bulldozed fire line may exceed the effects of the fire itself through lasting changes in the soil and vegetation properties; however, little research has been performed to quantify these impacts in grassland systems. In this study, we compared vegetation properties among burned, unburned, and bulldozed fire line conditions on two August 2012 grassland wildfires in Montana. Standing biomass, by growth form, was quantified in 2013 and 2014, and compared using a generalized linear model. Perennial grass production was significantly reduced, while annual grass and annual forb biomass increased in response to the fire line treatment. Shrub and total vegetation standing crop were reduced in response to the fire line in 2013; however, the treatment effects were diminished by 2014. The burned and unburned treatments were generally similar within two years post-fire. The loss of perennial grasses and invasion of competitive annual grasses such as cheatgrass (Bromus tectorum L.) may limit the vegetation recovery of the fire line and promote further invasion of annual grasses into these systems. The marginal impact of the fires on these plant communities suggests the need to limit the use of ad hoc bulldozed fire lines as a suppression activity. If a bulldozed fire line is constructed, we suggest limiting soil disturbance by restricting blade depth to remove only surface vegetation and restricting bulldozer use to flat slopes, even if working with the contour, and incorporating re-seeding as part of or immediately after fire line construction.
Correlating Morphology and Multifractal Spatial Patterns of the Leaf Surface Architecture of Anacardium occidentale L.
Authors: Ramos Glenda Quaresma , Matos Robert Saraiva , Das Abhijeet , Kumar Sanjeev , Ţălu Ştefan , da Fonseca Filho Henrique Duarte
Published: June 2022

Plant leaf surfaces can contain interesting, reproducible spatial patterns that can be used for several industrial purposes. In this paper, the main goal was to analyze the surface microtexture of Amazon Anacardium occidentale L. using multifractal theory. AFM images were used to evaluate the multifractal spatial surface patterns of the adaxial and abaxial sides of the leaf. The 3D maps revealed that the abaxial side is dominated by stomach cells, while striated structures were observed on the adaxial side. The surface of the abaxial side is rougher than the adaxial side. The autocorrelation function calculations showed that the abaxial side has an isotropic surface compared to the adaxial side. Despite this, Minkowski functionals demonstrated that the morphological spatial patterns have robust statistical similarity. Both sides exhibit multifractal behavior, which was verified by the trend observed in the mass exponent and generalized dimension. However, the adaxial side exhibits stronger multifractality and increased vertical complexity compared to the abaxial side. Our findings show that the multifractal spatial patterns of the leaf surface depend on the rough dynamics of the topographic profile. The identification of the multifractal patterns of the structures present on the surface of plant leaves is useful for the fabrication of leaf-architecture-based materials.
Elemental Mapping and Characterization of Petroleum-Rich Rock Samples by Laser-Induced Breakdown Spectroscopy (LIBS)
Authors: Quarles Charles Derrick , Miao Toni , Poirier Laura , Gonzalez Jhanis Jose , Lopez-Linares Francisco
Published: June 2022

The application of Laser-Induced Breakdown Spectroscopy (LIBS) is presented for the direct elemental analysis of hydrocarbon-rich solids. In recent years, LIBS has become a powerful tool for obtaining elemental information and mapping analysis of different petroleum-rich samples with minimal to no sample preparation and without the need to separate the organic matter from the inorganic matter. By selecting the most intense and representative lines, the element distribution in a 2D map can be accessed in less than ten hours. For this reason, two types of hydrocarbon-rich solids were chosen for examination, i.e., core and shale. Nineteen elements were identified in the samples, and 2D mapping for Ca, Mg, Fe, Ti, Ni, C, H, K, O, and S is presented here. A detailed distribution of the elements, and the main components of the hydrocarbons present in these samples, were determined using LIBS. The H/C molar ratio was determined by building H and C calibration curves using data obtained from classical elemental analysis via combustion. These calibration curves contained a high degree of linearity (R2 > 0.98) with the limits of detection for C (193 nm), C (247 nm), and H (656 nm) of 848 mg kg−1, 353 mg kg−1, and 3.5 mg kg−1, respectively. By combining all of this information, LIBS allowed us to determine how these elements were spatially distributed, which elements were dominant in a given sample, and how much hydrocarbon was present, as well as providing a quantitative determination of the H/C molar ratio, and its correlation with the source of origin.
Hypothesis: Why Different Types of SDH Gene Variants Cause Divergent Tumor Phenotypes
Authors: Bayley Jean-Pierre , Devilee Peter
Published: June 2022

Despite two decades of paraganglioma-pheochromocytoma research, the fundamental question of how the different succinate dehydrogenase (SDH)-related tumor phenotypes are initiated has remained unanswered. Here, we discuss two possible scenarios by which missense (hypomorphic alleles) or truncating (null alleles) SDH gene variants determine clinical phenotype. Dysfunctional SDH is a major source of reactive oxygen species (ROS) but ROS are inhibited by rising succinate levels. In scenario 1, we propose that SDH missense variants disrupt electron flow, causing elevated ROS levels that are toxic in sympathetic PPGL precursor cells but well controlled in oxygen-sensing parasympathetic paraganglion cells. We also suggest that SDHAF2 variants, solely associated with HNPGL, may cause the reversal of succinate dehydrogenase to fumarate reductase, producing very high ROS levels. In scenario 2, we propose a modified succinate threshold model of tumor initiation. Truncating SDH variants cause high succinate accumulation and likely initiate tumorigenesis via disruption of 2-oxoglutarate-dependent enzymes in both PPGL and HNPGL precursor tissues. We propose that missense variants (including SDHAF2) cause lower succinate accumulation and thus initiate tumorigenesis only in very metabolically active tissues such as parasympathetic paraganglia, which naturally show very high levels of succinate.
Metallothioneins in Dental Implant Treatment Failure and Periodontitis in Patients with Down’s Syndrome: Validation of Results
Authors: Baus-Domínguez María , Gómez-Díaz Raquel , Gutiérrez-Pérez José-Luis , Torres-Lagares Daniel , Machuca-Portillo Guillermo , Serrera-Figallo María-Ángeles
Published: June 2022

Metallothioneins (MTs) are low molecular weight cysteine-rich proteins that can bind up to seven zinc ions. Among their numerous functions, MTs appear to act as protectors against oxidative and inflammatory injury. In our first published study, we reported downregulation of the isoforms MT1B (fold distance (FD) −2. 95; p = 0.0024), MT1F (FD −1.72; p = 0.0276), MT1X (FD −3.09; p = 0.0021), MT1H (FD −2.39; p = 0.0018), MT1M (FD −2.37; p = 0.0092), MT1L (FD −2. 55; p = 0.0048), MT1E (FD −2.71; p = 0.0014), MT2A (FD −2.35; p = 0.0072), MT1G (FD −2.24; p = 0.0118), and MT1A (FD −2.82; p = 0.0023) by comparing Down’s syndrome patients with periodontal disease and implant failure to those without periodontal disease and with a positive progression of their implants. In this gene validation study, we intended to verify the results of our first gene expression analysis. Materials and Methods: In our retrospective case–control study, we performed retrotranscription (RT-qPCR) of 11 RNA-to-cDNA samples using the SuperScript™ VILO™ kit (50; reference 1,176,605) from Thermo Fisher. We conducted the study using the real-time PCR technique on the q-PCR ViiA 7 platform from Thermo Fisher. We chose the format of the Taqman Array Plate 16 Plus (reference 4,413,261) from Thermo Fisher, which accommodates 12 genes plus four controls (GAPDH, 18S, ACTB, and HPRT1). We conducted the analysis of the plates using the Thermo Fisher Cloud Web Software. Results: The results obtained through gene validation analysis show that in PD+RI+ patients, the genes encoding the isoforms MT1F (FD 0.3; p = 0.039), MT1X (FD 338; p = 0.0078), MT1E (FD 307; p = 0.0358), and MT2A (FD 252; p = 0.0428) continue to show downregulation, whereas MT1B (FD 2.75; p = 0.580), MT1H (FD 281; p = 0.152), MT1L (FD 354; p = 0.0965), and MT1G (FD 336; p = 0.0749) no longer show statistically significant results.
Integrated Analysis of mRNAs and Long Non-Coding RNAs Expression of Oviduct That Provides Novel Insights into the Prolificacy Mechanism of Goat (Capra hircus)
Authors: Sun Zhipeng , Zhang Zijun , Liu Yufang , Ren Chunhuan , He Xiaoyun , Jiang Yanting , Ouyang Yina , Hong Qionghua , Chu Mingxing
Published: June 2022

Artificial directional selection has replaced natural selection and resulted in trait differences across breeds in domestic animal breeding. However, the molecular mechanism by which the oviduct regulates litter size remains largely elusive in goats during the follicular phase. Accumulating data have linked lncRNAs to reproductive activities; however, little is known about the modulation mechanism in the oviduct. Herein, RNA-seq was used to measure mRNA and lncRNA expression levels in low- and high-fecundity goats. We observed distinctive differences in mRNA and lncRNA in terms of different kidding numbers and detected the differential expression of 1640 mRNA transcripts and 271 lncRNA transcripts. Enrichment analysis of differentially expressed mRNAs (DEGs) suggested that multiple pathways, such as the AMPK, PI3K–Akt, calcium signaling pathway, oocyte meiosis, ABC transporter, and ECM–receptor interaction pathways, directly or indirectly affected goat reproduction. Additionally, coexpression of differentially expressed lncRNAs (DEL)-genes analysis showed that XLOC_021615, XLOC_119780, and XLOC_076450 were trans-acting as the DEGs ATAD2, DEPDC5, and TRPM6, respectively, and could regulate embryo development. Moreover, XLOC_020079, XLOC_107361, XLOC_169844, XLOC_252348 were the trans-regulated elements of the DEGs ARHGEF2 and RAPGEF6, and the target DEGs CPEB3 of XLOC_089239, XLOC_090063, XLOC_107409, XLOC_153574, XLOC_211271, XLOC_251687 were associated with prolificacy. Collectively, our study has offered a thorough dissection of the oviduct lncRNA and mRNA landscapes in goats. These results could serve as potential targets of the oviduct affecting fertility in goats.
Effect of miR-101 on the Proliferation and Apoptosis of Goat Hair Follicle Stem Cells
Authors: Qu Jingwen , Wu Xi , Wang Qiang , Wang Jian , Sun Xiaomei , Ji Dejun , Li Yongjun
Published: June 2022

The Yangtze River Delta white goat is a rare goat species capable of producing high-quality brush hair. Dual specificity protein phosphatase 1 (DUSP1) may play a role in the formation of high-quality brush hair, as evidenced by our previous research. We investigated the potential mechanisms that regulate the proliferation and apoptosis of goat hair follicle stem cells. We particularly focused on the relationship between DUSP1 and miR-101, which directly targets DUSP1, predicted and screened through bioinformatics websites. Then, fluorescence assays, flow cytometry, RT-qPCR, and Western blotting were used to investigate the effects of miR-101 on the proliferation and apoptosis of hair follicle stem cells. We found that miR-101 overexpression significantly decreased (p < 0.01) apoptosis and promoted the proliferation of hair follicle stem cells. Furthermore, the overexpression of miR-101 increased (p < 0.05) the mRNA and protein expression levels of the proliferation-related gene (PCNA) and anti-apoptotic gene (Bcl-2), and it decreased (p < 0.05) the mRNA and protein expression levels of the apoptotic gene (Bax). In conclusion, miR-101 can promote the proliferation of and inhibit the apoptosis of hair follicle stem cells by targeting DUSP1, which provides a theoretical basis for further elucidating the molecular mechanism that regulates the production of high-quality brush hair of Yangtze River Delta white goats.
Circulating miRNAs as Potential Biomarkers for Patient Stratification in Bipolar Disorder: A Combined Review and Data Mining Approach
Authors: Clausen Alexandra R. , Durand Simon , Petersen Rasmus L. , Staunstrup Nicklas H. , Qvist Per
Published: June 2022

Bipolar disorder is a debilitating psychiatric condition that is shaped in a concerted interplay between hereditary and triggering risk factors. Profound depression and mania define the disorder, but high clinical heterogeneity among patients complicates diagnosis as well as pharmacological intervention. Identification of peripheral biomarkers that capture the genomic response to the exposome may thus progress the development of personalized treatment. MicroRNAs (miRNAs) play a prominent role in of post-transcriptional gene regulation in the context of brain development and mental health. They are coordinately modulated by multifarious effectors, and alteration in their expression profile has been reported in a variety of psychiatric conditions. Intriguingly, miRNAs can be released from CNS cells and enter circulatory bio-fluids where they remain remarkably stable. Hence, peripheral circulatory miRNAs may act as bio-indicators for the combination of genetic risk, environmental exposure, and/or treatment response. Here we provide a comprehensive literature search and data mining approach that summarize current experimental evidence supporting the applicability of miRNAs for patient stratification in bipolar disorder.
Evidence of Seismic-Related Liquefaction Processes within the Volcanic Record of the Campi Flegrei Caldera (Italy)
Authors: Vitale Stefano , Natale Jacopo , Isaia Roberto , Tramparulo Francesco D’Assisi , Ciarcia Sabatino
Published: June 2022

We report the occurrence of several sand liquefaction structures, such as sand dikes, in the stratigraphic record of the Campi Flegrei volcano, located both inside and outside the caldera. Five sites were analyzed within the caldera and two outside. The grain size analysis of the sand fillings indicates that these deposits are very fine-to-coarse sands generally poorly sorted. All of the granulometry curves fall within the field of the liquefiable, loose sediments. Frequently, dikes are characterized by two fillings: a rim showing poorly sorted finer sands and a core with extremely poorly sorted coarser sediments. We suggest that seismic-related liquefaction processes triggered the injection of these sand dikes during unrest episodes in the last 15 kyr. In particular, the sand dikes located outside the caldera, characterized by larger thicknesses and lengths, mark an important extensional episode, probably associated with the caldera formation during the Neapolitan Yellow Tuff eruption at 15 ka. Furthermore, liquefaction structures within the caldera are related to the seismic activity, probably occurring during the Agnano–Monte Spina caldera formation and the volcano-tectonic ground deformation, predating Epoch 3b (4.3 ka) and the Monte Nuovo (1538 CE) eruptions. This study highlights that these seismic-related liquefaction structures are common within the volcanic record of the Campi Flegrei, suggesting that the sand source can be both the widespread marine succession underlying the Epoch 3 deposits in the caldera central sector and the primary ash layers extensively present in the volcanic record.
Late Cretaceous through Cenozoic Paleoenvironmental History of the Bagua Basin, Peru: Paleoelevation Comparisons with the Central Andean Plateau
Authors: Moreno Federico , Garzione Carmala N. , George Sarah W. M. , Williams Lauren , Richter Fabiana , Bandeian Alice
Published: June 2022

Located in northern Peru, at the lowest segment of the Central Andes, the Bagua Basin contains a Campanian to Pleistocene sedimentary record that archives the local paleoenvironmental and tectonic history. We present new δ18O and δ13C signatures of pedogenic carbonate nodules from paleosols in the Campanian–Maastrichtian Fundo El Triunfo Formation and in the upper Eocene–middle Miocene Sambimera Formation to reconstruct the isotopic composition of paleo-meteoric water and the floristic biome. We compare these results to modern isotopic values from a newly obtained modern water transect to interpret the environmental evolution of this area and its relationship with the neighboring Eastern Cordillera. A ~2‰ δ18O depletion between the latest Cretaceous and the latest Eocene reflects a shift from a coastal to inland environment. A negative δ18O shift of ~3‰ from the middle Miocene to the present day reveals the establishment of the Eastern Cordillera as an orographic barrier for the moisture traveling westward, sometime after deposition of the top of the Sambimera Formation at ~13 Ma. A shift in the δ13C signature from ~−25‰ in the Campanian–Miocene deposits to ~−23‰ in modern–Holocene times suggests a change in biome from dominant C3 plants to a mixture of C3 and C4 plants. This environmental shift reflects both the late Miocene global C4 expansion and the transition to more arid conditions in the basin. The Campanian–middle Miocene environmental reconstruction of the Bagua Basin indicates a steady paleoelevation setting in the northernmost Central Andes during most of the Cenozoic and constrains the uplift of the Eastern Cordillera to the late Miocene–Pleistocene. This paleoelevation history contrasts with that of the Central Andean Plateau, which is characterized by two major episodes of surface uplift: early–middle Miocene and late Miocene–Pliocene. The contrasting modern topographic configuration of the Central Andean Plateau and the northernmost Central Andes gives rise to the question of what factors created such a dramatic difference in topographic evolution of the two regions that shared an overall common tectonic history. We discuss the possible factors responsible for this contrasting topographic configuration and suggest that the diachronous flat slab episodes are likely a major factor, resulting in greater shortening and crustal thickness and, ultimately, in earlier surface uplift episodes occurring in the Central Andean Plateau.
Does Parental Reflective Functioning Mediate the Associations between the Maternal Antenatal and Postnatal Bond with the Child in a Community Sample?
Authors: Pazzagli Chiara , Buratta Livia , Cenci Giulia , Coletti Elena , Giuliani Maria Luisa , Mazzeschi Claudia
Published: June 2022

Although establishing an affective tie with a child during perinatality is considered one of the most important maternal tasks, little is still known about the mediators of the association between maternal antenatal and postnatal bonding with the infant. This prospective study addresses this gap by evaluating a community sample of 110 Italian women to assess whether maternal pre- and postnatal bonds with the infant are mediated by parental reflective functioning (PRF), as assessed at the third trimester of pregnancy and three months postpartum. Controlling for confounding variables, the hierarchical regression analyses show the maternal prenatal quality of attachment to the fetus as the main predictor of maternal postnatal attachment to the child (β = 0.315; t = 0.2.86; p = 0.005). The mediation analyses show that mothers’ PRF (b = 0.245; SE = 0.119; 95% CI = 0.071, 0.531) explains 39% of the relationship between maternal pre- and postnatal bonding with the child. The findings of this study contribute to research on the association between prenatal and mother-to-infant bonding by additionally investigating the importance of taking into account maternal PRF as a mediating variable. This provides support for the clinical utility of interventions focused on maternal PRF.
Urine Di-(2-ethylhexyl) Phthalate Metabolites Are Independently Related to Body Fluid Status in Adults: Results from a U.S. Nationally Representative Survey
Authors: Wang Wei-Jie , Wang Chia-Sung , Wang Chi-Kang , Yang An-Ming , Lin Chien-Yu
Published: June 2022

Purpose: Di-(2-ethylhexyl) phthalate (DEHP) has been utilized in many daily products for decades. Previous studies have reported that DEHP exposure could induce renin–angiotensin–aldosterone system activation and increase epithelial sodium channel (ENaC) activity, which contributes to extracellular fluid (ECF) volume expansion. However, there is also no previous study to evaluate the association between DEHP exposure and body fluid status. Methods: We selected 1678 subjects (aged ≥18 years) from a National Health and Nutrition Examination Survey (NHANES) in 2003–2004 to determine the relationship between urine DEHP metabolites and body composition (body measures, bioelectrical impedance analysis (BIA)). Results: After weighing the sampling strategy in multiple linear regression analysis, we report that higher levels of DEHP metabolites are correlated with increases in body measures (body weight, body mass index (BMI), waist circumference), BIA parameters (estimated fat mass, percent body fat, ECF, and ECF/intracellular fluid (ICF) ratio) in multiple linear regression analysis. The relationship between DEHP metabolites and the ECF/ICF ratio was more evident in subjects of younger age (20–39 years old), women, non-Hispanic white ethnicity, and subjects who were not active smokers. Conclusion: In addition to being positively correlated with body measures and body fat, we found that urine DEHP metabolites were positively correlated with ECF and the ECF/ICF ratio in the US general adult population. The finding implies that DEHP exposures might increase ECF volume and the ECF/ICF ratio, which may have adverse health outcomes on the cardiovascular system. Further research is needed to clarify the causal relationship.
Fruit and Vegetable Consumption Patterns and Risk of Chronic Diseases of Lifestyle among University Students in Kenya
Authors: Nyanchoka Moriasi Abednego , van Stuijvenberg Martha Elizabeth , Tambe Ayuk Betrand , Zuma Mthokozisi Kwazi , Mbhenyane Xikombiso Gertrude
Published: June 2022

This study assesses the fruit and vegetable consumption patterns and risk factors for chronic diseases of lifestyle (CDL) among young adults attending Kenyatta University, Kenya. Four hundred and twenty-three young adults aged 19–30 years participated in the cross-sectional study. Males were 75.0% less likely to be overweight than females (OR = 0.25; 0.13–0.47). The mean overall consumption of fruit and/or vegetables amounted to 3.6 servings in a typical day. Eight in ten participants consumed lower amounts of fruits and vegetables than recommended by the WHO. At least one combined risk factor of CDL was observed among 91.3% of the young adults. About 8.7% of the participants were classified as low risk for CDL (having none of the five risk factors), 48.9% had one risk factor, 32.9% had two risk factors, 8.5% had three risk factors, while 0.9% had four risk factors. A significant relationship between daily fruit consumption and waist circumference was observed. These findings show the dire need to develop public health nutrition activities aimed at increasing the intake of fruit and vegetables and sensitizing young adults, and the general population, to the risk factors of CDL.
More Prosocial, More Ephemeral? Exploring the Formation of a Social Entrepreneur’s Exit Intention via Life Satisfaction
Authors: Dong Jianing , Wang Xiao , Cao Xuanwei , Higgins David
Published: June 2022

This study was designed to test if satisfaction with health and personal financial wellbeing mediates the relationship between prosocial motivations and exit intentions among social entrepreneurs. Using a sample of 317 social entrepreneurs, the partial least square structural equation modeling (PLS-SEM) revealed that prosocial motivation decreased the financial satisfaction of entrepreneurs, which increased their exit intentions. However, health satisfaction did not have a mediating effect on the relationship between prosocial motivation and exit intention. Moreover, adopting the multi-group analysis (MGA) technique, we found that the negative impact of prosocial motivation on financial satisfaction was stronger for males than for females, suggesting male entrepreneurs were more likely to experience lower financial satisfaction caused by prosocial motivation than female entrepreneurs. There was no evidence that gender moderated the relationship between prosocial motivation and health satisfaction.
Sexual Self-Concept Differentiation: An Exploratory Analysis of Online and Offline Self-Perspectives
Authors: Mateizer Alexandru , Roșca Andra Cătălina , Avram Eugen
Published: June 2022

Self-concept differentiation (SCD) has been of interest to researchers, mainly as a structural concept indicative of social specialization or self-concept fragmentation. Nevertheless, this aspect of self-representation has not been studied in regard to sexuality and the extent to which the sexual self may vary across different roles or situations. With the emergence of the Internet, people found new opportunities to explore and express aspects of their sexuality in multiple online scenes, thus increasing the complexity of human sexual experience and expanding the reach of sexual identity. The aim of this study is to investigate SCD in relation to the sexual self-concept, as experienced in the online and offline environments, and its effects on sexual identity, sexual satisfaction and online sexual behaviors. Data analysis pointed towards a fragmented self-view with high degrees of differentiation between the online and offline sexual self-instances being linked to a weaker sense of sexual identity, less sexual satisfaction in real life and less partnered online interactions. However, there were some indications that these relationships were influenced by how people perceive themselves sexually in one instance compared to the other. The results obtained in this study encourage further research on SCD as an important factor in understanding the real-world consequences of online sexual expression.
A Data-Driven Optimized Mechanism for Improving Online Collaborative Learning: Taking Cognitive Load into Account
Authors: Zhang Linjie , Wang Xizhe , He Tao , Han Zhongmei
Published: June 2022

Research on online collaborative learning has explored various methods of collaborative improvement. Recently, learning analytics have been increasingly adopted for ascertaining learners’ states and promoting collaborative performance. However, little effort has been made to investigate the transformation of collaborative states or to consider cognitive load as an essential factor for collaborative intervention. By bridging collaborative cognitive load theory and system dynamics modeling methods, this paper revealed the transformation of online learners’ collaborative states through data analysis, and then proposed an optimized mechanism to ameliorate online collaboration. A quasi-experiment was conducted with 91 college students to examine the potential of the optimized mechanism in collaborative state transformation, awareness of collaboration, learning achievement, and cognitive load. The promising results demonstrated that students learning with the optimized mechanism performed significantly differently in collaboration and knowledge acquisition, and no additional burden in cognitive load was noted.
Knowledge Mapping of the Phytoremediation of Cadmium-Contaminated Soil: A Bibliometric Analysis from 1994 to 2021
Authors: Zhao Xiaofeng , Lei Mei , Gu Runyao
Published: June 2022

Cadmium pollution of soil threatens the environmental quality and human health. Phytoremediation of cadmium-contaminated soil has attracted global attention in recent decades. This study aimed to conduct a comprehensive and systematic review of the literature on phytoremediation of cadmium-contaminated soil based on bibliometric analysis. A total of 5494 articles published between 1994 and 2021 were retrieved from the Web of Science Core Collection. Our knowledge mapping presented the authors, journals, countries, institutions, and other basic information to understand the development status of phytoremediation of cadmium-contaminated soil. Based on a keyword cluster analysis, the identified major research domains were “biochar”, “Thlaspi caerulescens”, “endophytic bacteria”, “oxidative stress”, “EDTA”, and “bioconcentration factor”. Overall, this study provided a detailed summary of research trends and hotspots. Based on the keyword co-occurrence and burst analysis, the core concepts and basic theories of this field were completed in 2011. However, the pace of theoretical development has been relatively slow. Finally, future research trends/frontiers were proposed, such as biochar addition, rhizosphere bacterial community manipulation, cadmium subcellular distribution, and health risk assessment.
Effectiveness of a Hybrid Exercise Program on the Physical Abilities of Frail Elderly and Explainable Artificial-Intelligence-Based Clinical Assistance
Authors: Meng Deyu , Guo Hongzhi , Liang Siyu , Tian Zhibo , Wang Ran , Yang Guang , Wang Ziheng
Published: June 2022

Background: Due to the low physical fitness of the frail elderly, current exercise program strategies have a limited impact. Eight-form Tai Chi has a low intensity, but high effectiveness in the elderly. Inspired by it, we designed an exercise program that incorporates eight-form Tai Chi, strength, and endurance exercises, to improve physical fitness and reverse frailty in the elderly. Additionally, for the ease of use in clinical practice, machine learning simulations were used to predict the frailty status after the intervention. Methods: For 24 weeks, 150 frail elderly people completed the experiment, which comprised the eight-form Tai Chi group (TC), the strength and endurance training group (SE), and a comprehensive intervention combining both TC and SE (TCSE). The comparison of the demographic variables used one-way ANOVA for continuous data and the chi-squared test for categorical data. Two-way repeated measures analysis of variance (ANOVA) was performed to determine significant main effects and interaction effects. Eleven machine learning models were used to predict the frailty status of the elderly following the intervention. Results: Two-way repeated measures ANOVA results before the intervention, group effects of ten-meter maximum walking speed (10 m MWS), grip strength (GS), timed up and go test (TUGT), and the six-minute walk test (6 min WT) were not significant. There was a significant interaction effect of group × time in ten-meter maximum walking speed, grip strength, and the six-minute walk test. Post hoc tests showed that after 24 weeks of intervention, subjects in the TCSE group showed the greatest significant improvements in ten-meter maximum walking speed (p < 0.05) and the six-minute walk test (p < 0.05) compared to the TC group and SE group. The improvement in grip strength in the TCSE group (4.29 kg) was slightly less than that in the SE group (5.16 kg). There was neither a significant main effect nor a significant interaction effect for TUGT in subjects. The stacking model outperformed other algorithms. Accuracy and the F1-score were 67.8% and 71.3%, respectively. Conclusion: A hybrid exercise program consisting of eight-form Tai Chi and strength and endurance exercises can more effectively improve physical fitness and reduce frailty among the elderly. It is possible to predict whether an elderly person will reverse frailty following an exercise program based on the stacking model.
Roles of Indulgence versus Restraint Culture and Ability to Savor the Moment in the Link between Income and Subjective Well-Being
Authors: Li Bin , Wang Sijun , Cui Xinyue , Tang Zhen
Published: June 2022

Over the past few decades, various academic fields have reported contradictory findings regarding whether income is positively or negatively associated with subjective well-being (SWB). To reconcile the inconclusive observations, researchers tend to use various mediators and moderators that could explain why income is more strongly associated with SWB for certain groups of people and why income could be negatively associated with SWB for other groups. This study endeavored to first test additional mediation roles of financial satisfaction and a sense of control in the link between income and three related yet distinct measures of SWB: life satisfaction, happiness, and emotional well-being (EWB), at both cross-national and individual levels. We further investigated the direct and moderating impacts of national difference in Indulgence versus Restraint (IVR) cultural orientations over two mediating mechanisms (income → financial satisfaction → SWB; income → a sense of control → SWB) using data from 49,097 participants in the 2017–2020 World Values Survey. Additionally, we conducted a moderated mediation analysis of individual difference in ability to savor the moment (ASM) for these two mediating mechanisms based on surveys with 796 respondents from China. Analyses at both national level and individual level confirmed the partial mediating roles of financial satisfaction and a sense of control. We further find a positive, direct impact of IVR on SWB such that people in more indulgence cultures report a higher SWB than those in more restraint cultures. The mediating effects of financial satisfaction were found to be weaker in more indulgence cultures than in more restraint ones, while the mediating effects of a sense of control remain the same. Finally, we find that individuals’ ASM does not only directly lead to a higher SWB, but also amplifies the mediation impact of financial satisfaction in the link between income and life satisfaction and in the link between income and EWB. Implications of these findings are offered for public policy makers, employers, and citizens, as well as researchers from different fields.
Suicide among Older People in Different European Welfare Regimes: Does Economic (in)Security Have Implications for Suicide Prevention?
Authors: Wu Jing , Li Ying , Waern Margda
Published: June 2022

Older adult suicide rates vary widely within Europe, and differential welfare policies might contribute to this. We studied variations in economic indicators and suicide rates of people 65+ across 28 European countries and examined the effects of these indicators on suicide rates, grouping countries according to their socio-political systems and welfare regimes. Suicide data was obtained from the WHO European Mortality Database. The European Union Statistics on Income and Living Conditions and the European Union Labour Force Survey provided data on economic indicators. Linear mixed models were applied. Suicide rates ranged from 4.22/100,000 (Cyprus) to 36.37/100,000 (Hungary). Material deprivation was related to elevated suicide rates in both genders in the pooled data set and in men but not women in the Continental and Island countries. Higher ratio of median income (65+/under 65) was associated with lower likelihood of suicide in women in the South-Eastern European countries. In the Nordic region, the 65+ employment rate was associated with a decreased likelihood of suicide in men. These factors to some extent show economic insecurity against older people, which influences the likelihood of suicide. Active labor market policies and inclusive social environment may contribute to suicide prevention in this age group.
Association between Exposure to Ambient Air Pollution and the Risk of Rheumatoid Arthritis in Taiwan: A Population-Based Retrospective Cohort Study
Authors: Ho Wen-Chao , Chou Li-Wei , Wang Ruey-Yun , Doan Thanh-Nhan , Yu Hwa-Lung , Chou Ting-Hsuan , Liu Kang-Yung , Wu Po-Chang , Shieh Shwn-Huey
Published: June 2022

Background: The association between ambient air pollution (AAP) and the risk of Rheumatoid arthritis (RA) remains debatable. We conducted a population-based cohort study to investigate the association between exposure to AAP and the risk of RA in Taiwan. Methods: We analyzed and combined the longitudinal Health Insurance Database (LHID) and the Taiwan Air Quality-Monitoring Database (TAQMD), which were in line with the residential areas. We calculated the RA incidence rates per 10,000 person-years exposed to each quartile of PM2.5 or PM10 concentrations or RH. Hazards regression was conducted to analyze the associations between exposure to each quartile of PM2.5 and PM10 concentrations and the risk of developing RA. The hazard ratios of RA were analyzed between participants exposed to annual average concentrations of PM2.5 and PM10. All the hazard ratios of RA were stratified by gender and adjusted for age and relative humidity (RH). A p-value < 0.05 was considered statistically significant. Results: Among 722,885 subjects, 9338 RA cases were observed. The analyses adjusted for age, gender, and humidity suggested an increased risk of developing RA in the exposure to PM2.5 in the last quartile (Q4) with the adjusted hazard ratio (aHR) was 1.053 (95%CI: 1.043 to 1.063). Conclusion: Our study suggests that exposure to PM2.5 is associated with an increased risk of RA. The finding has implications for policymaking to develop coping strategies to confront AAP as a risk factor for RA.
Investigating Strategies of Emotion Regulation As Mediators of Occupational Stressors and Mental Health Outcomes in First Responders
Authors: Kshtriya Sowmya , Lawrence Jacqueline , Kobezak Holly M. , Popok Paula J. , Lowe Sarah
Published: June 2022

The aim of this study was to investigate whether two emotion regulation strategies, expressive suppression or cognitive reappraisal, mediated the development of posttraumatic stress disorder (PTSD), major depression (MD), and generalized anxiety disorder (GAD) in first responders (FR) who experienced occupational stressors, using cross-sectional data. An aggregate of 895 first responders (M = 37.32, SD = 12.09, 59.2% male, 91.3% Caucasian) who were recruited through professional organizations and social media sites across North and South American states participated in an online Qualtrics survey. Bivariate correlation analyses demonstrated that occupational stressors were positively correlated with expressive suppression and each mental health outcome but were not significantly correlated with cognitive reappraisal. Mediation analyses demonstrated expressive suppression as a significant mediator between occupational stressors and PTSD, MD, and GAD symptoms, but not cognitive reappraisal. Even though these findings are in purview of a cross-sectional research design, they suggest the importance of practices that bolster first responders’ ability to use more effective and adaptive emotion regulation strategies such as emotion expression, effective communication, and cognitive reappraisal that might help enhance psychological resilience.
Relation between Noise Pollution and Life Satisfaction Based on the 2019 Chinese Social Survey
Authors: Yang Dongliang , Liu Xiangheng , Ren Zhichao , Li Mingna
Published: June 2022

Noise pollution is a leading cause of decreasing well-being of residents in both developed and developing countries. Improving residents’ well-being measured by life satisfaction is a key goal of government policy. Individuals with high life satisfaction usually have positive emotions, life orientation, and codes of conduct, which are positive and beneficial for individuals, families, and society as a whole. In order to supplement relevant research and provide policy suggestions for individuals, government, and societies, this study explores the relationship between noise pollution and the life satisfaction of Chinese residents. Based on data from 4869 observations from the Chinese Social Survey in 2019, the effect of noise pollution on life satisfaction is estimated by using ordinary least squares and propensity score matching methods. The results show that noise pollution has a significant negative effect on Chinese life satisfaction. Moreover, the effect is heterogeneous depending on individuals’ education levels and ages. Finally, residents’ living environment satisfaction is shown to be the potential mechanism by which noise pollution affects life satisfaction.
Research on Multi-Dimensional Influencing Factors Regarding the Perceived Social Integration of New Urban Immigrants: An HLM Analysis Based on Data from 58 Large- and Medium-Sized Cities in China
Authors: Li Fulian , Sun Yang , Zhang Youlu , Zhang Wuwei
Published: June 2022

Based on the China Migrants Dynamic Survey (CMDS) data from 2018 and the data from 58 large- and medium-sized cities in China, in this paper a hierarchical linear model was used to investigate the impact of demographic characteristics, social participation, and economic and social development on the perceived social integration of new urban immigrants at the individual and urban levels. The results revealed the following: (1) social participation, gender, age, education, health status, flow time and housing type of new urban immigrants had a significant positive impact on their perceived social integration, while income showed a U-shaped relationship with the sense of urban social integration; (2) macro-urban characteristics regulated the correlation between micro-individual factors and perceived social integration; (3) the significant advantages of new urban immigrants with higher education and more social participation in the process of integration into urban society were more obvious in cities with higher levels of economic development or public services. These findings enriched relevant research on the factors influencing the social integration of new urban immigrants and provided valuable insight with which the government could use to improve urban construction and promote the equalization of basic public services.