bluuebunny/crossref_metadata_2025 huggingface dataset:
Hypertension Promotes Neuroinflammation, Brain Injury and Cognitive Impairment
Authors: Dinh Quynh , Vinh Antony , Lo Cecilia , Zhang David Wong , Selvaraji Sharmelee , Kim Hyun Ah , Chrissobolis Sophocles , Arumugam Thiruma Valavan , Drummond Grant , Sobey Christopher , Silva T. Michael De
Published: July 2023

Background and purpose: Hypertension increases the risk for cognitive
impairment and promotes vascular and renal inflammation. We tested if
immune cell infiltration occurs in the brain during hypertension and if
it is associated with cognitive impairment. Experimental approach: Male
C57Bl/6 mice were administered vehicle, angiotensin II (0.7 mg/kg/d
S.C.) or aldosterone (0.72 mg/kg/d S.C.) via osmotic minipumps. A subset
of mice also received hydralazine (50 mg/kg) in their drinking water
after minipump implantation. We measured systolic blood pressure,
markers of inflammation, working memory and transcriptomic changes in
the brain. Key results: Administration of angiotensin II or aldosterone
increased blood pressure and promoted blood-brain barrier dysfunction,
leukocyte accumulation and impairment of working memory in mice. When
co-administered with angiotensin II, hydralazine prevented the
development of these changes. In a separate cohort of mice in which
angiotensin II-induced changes were first established, intervention with
hydralazine lowered blood pressure but did not reverse brain
inflammation or cognitive impairment. Finally, angiotensin II infusion
altered the transcriptomic profile of the whole brain, as well as
specifically within the hippocampus, and co-treatment with hydralazine
modulated these changes. Conclusion and implications: Experimental
hypertension leads to brain inflammation and impaired working memory.
Cognitive impairment that develops during hypertension can be inhibited,
but not readily reversed, by anti-hypertensive therapy.
Relationship between infection, physical and mental health and exercise habits of some Chinese residents after recovery from COVID-19
Authors: Zhou Aiyi , XIA Yun-can , PI Peng , WANG Zheng-zhen , Hong-mei Huang , WANG Yan
Published: July 2023

Objective The purpose of this study was to obtain the infection
status, exercise, anxiety and sleep quality of some Chinese residents
who recovered from infection during the COVID-19 pandemic, explore the
influencing factors of recovery status, and help improve the
intervention measures for COVID-19 recovery. Methods This study
is a sub-study, nested within a cross-sectional study, investigating the
infection and physical and mental health of partially recovered
residents in all 34 provincial areas of China during the COVID-19
epidemic. Results There were 1013 participants in this study,
including 374 males and 639 females. The cardiopulmonary endurance after
infection was significantly lower than that before infection
(P<0.01). Among all participants, women (3.92±4.97) had more
anxiety than men (3.33±4.54, P<0.01); The sleep score after
infection (8.27±7.05) was significantly higher than that before
infection (4.17±4.97, P<0.01). The days of fever remission in
regular exercise and sedentary group were significantly shorter than
those in irregular exercise and sedentary group (P<0.05). The
days of fever remission in regular exercise group (1.81±1.91) was
significantly shorter than that in irregular exercise group (2.02±1.95,
P<0.05). The number of negative days in the non-sedentary
group (7.32±3.24) was significantly lower than that in the sedentary
group (7.66±3.06, P<0.05). Conclusions In this study,
it was observed that the recovery time of symptoms after COVID-19
recovery was related to age, and the more symptoms there were, the worse
cardiopulmonary fitness and sleep quality would be. Sedentary people and
irregular exercise people generally took a longer time to turn negative.
Therefore, appropriate exercise, psychological and sleep hygiene and
other health interventions should be considered in COVID-19 recovery
measures.
Urinary tract infection associated with bacteremia caused by vancomycin-resistant enterococcus following continent urinary diversion
Authors: Morishita Kai , Kashiwabara Soichiro , Matsumoto Yuki , Mizushima Atsuhiro , Hara Kaori , Agatsuma Toshihiko , Mimura Yuji , Matsumura Hideyoshi , Mizusawa Hiroya
Published: July 2023

Introduction: Vancomycin-resistant enterococcus is rare in Japan.
However, as there is a risk of in-hospital outbreak, this infectious
disease is clinically important. Case presentation: The patient was a
49-year-old Japanese female living in the United States. At her previous
hospital in the United States, total pelvic exenteration for cervical
carcinoma, Miami pouch
Clinical Pharmacokinetics and dose optimization of anti-infectives in critical care: A review
Authors: Rohilla Rachna , Kondel Ritika , Shafiq Nusrat , Malhotra Samir
Published: July 2023

Critically ill patients with infections present with considerable
challenges in antimicrobial use due to multiple reasons such as
pathophysiological alterations, comorbidities, supportive treatment and
the pathogenicity of implicated organism. Fluid shifts, hyperdynamic
state, altered renal clearance are the rapid changes which are often not
considered while administering antimicrobials. Vital organ dysfunction
with or without Multi–Organ Dysfunction Syndrome (MODS) often
necessitates use of supportive management in the form of Ventilatory
Support or Renal Replacement Therapy (RRT) to Extracorpeal Membrane
Oxygenation (ECMO) to name a few. These supportive measures may have
implication on PK-PD of administered antimicrobials. Certain patient
parameters such as age, weight, comorbid illnesses like cystic fibrosis,
burns or immunocompromised state can be important determinants of
pharmacokinetics and pharmacodynamics (PK-PD) of antimicrobials. Issues
such as bioavailability of the antimicrobial at the primary focus of
infection need to be taken into consideration while making choice of
antimicrobial(s) and deciding a dose. The critical pharmacodynamic
parameters that need to be taken into account consider are disease
state, altered bacterial susceptibility, pathogenicity and localization
of the organism and host immunity while making decisions about optimized
antimicrobial treatment in a critically ill patient with infection. The
current review delves on these nuances with a focus on PK-PD for
optimized use of antimicrobials in a critically ill patient.
Temprospatial Dynamics of the Morphogenesis of the Rabbit Retina from Prenatal to Postnatal Life: Light, Immunohistochemical and Electron Microscopic Study
Authors: Ibrahim Nagwa , El-Desoky Sara M. M. , Elhanbaly Ruwaida , Hifny Abdalla , Gaber Wafaa
Published: July 2023

The retina consists of various cell types arranged in eight cell layers
and two membranes that originate from the neuroectodermal cells. The
purpose of this study is to evaluate the morphogenesis of the retina by
using light and electron microscopy, as well as immunohistochemical
techniques. The timing of differentiation and distribution of the
cellular component and the layers of the rabbit retina are investigated.
There were 32 rabbit embryos and 12 rabbits used. The rabbit retina
begins its prenatal development on the tenth day of gestation in the
form of optic cup. The process of neuro- and glio-genesis occurs in
several stages; in the first stage, the ganglionic cells are
differentiated. The second stage includes the differentiation of Muller,
amacrine and cone cells. The differentiation of bipolar, horizontal and
rod cells consider the late stage of neuro-genesis. All these stages
occur during the embryonic period. Then the retina continues its
development postnatally by formation of the outer segment of
photoreceptor layer and the all layers of the rabbit retina are
established. By immunohistochemical studies, the S100 protein is
expressed by the Muller cells that locate in the inner nuclear layer and
its radiating processes that traverse the retina from the outer to the
inner limiting membranes. Concerning to Calretinin, it is labeled within
the amacrine cells which occupy the inner nuclear layer and the
displaced amacrine cells that locate in the ganglionic cell layer.
Periodic wave-guides revisited: Radiation conditions, limiting absorption principles, and the space of bounded solutions
Authors: Kirsch Andreas , Schweizer Ben
Published: July 2023

We study the Helmholtz equation with periodic coefficients in a closed
wave-guide. A functional analytic approach is used to formulate and to
solve the radiation problem in a self-contained exposition. In this
context, we simplify the non-degeneracy assumption on the frequency.
Limiting absorption principles (LAPs) are studied and the radiation
condition corresponding to the chosen LAP is derived; we include an
example to show different LAPs lead, in general, to different solutions
of the radiation problem. Finally, we characterize the set of all
bounded solutions to the homogeneous problem.
Considerações metodológicas sobre a avaliação farmacoeconômica de custo-minimização
Authors: Floriano Nascimento Harrison , Ferreira Fernades Machado Juliana , Assunção Costa Lindemberg
Published: July 2023

A Avaliação de Custo-minimização (ACM) é, por definição, um tipo de avaliação farmacoeconômica completo, porém mais simples em relação aos demais, pois parte do pressuposto de que as alternativas farmacoterapêuticas em comparação têm desfechos (efetividade, eficácia e segurança) equivalentes (idênticos), bastando apenas comparar os custos. O objetivo deste artigo é tecer considerações com relação ao rigor metodológico necessário para que estudos de ACM possam subsidiar es-colhas e decisões assertivas sobre tecnologias em saúde que justifiquem a alocação de recursos financeiros por parte dos gestores de saúde.
Flavonoid derivatives as anticancer moiety and its effect on cancer cell lines: An updated review
Authors: Manojmouli Chandramouli , Pasha Thoppalada , Nagaprashant Koppuravuri , Ramesh Beevinahalli , Ul Eain , Purushotham Kardigere
Published: July 2023

Cancer is now considered the number one leading cause of premature death in industrialized countries. Chemotherapy drugs are quite expensive and cause multiple side effects. Natural products have been studied in depth for their potential as anticancer agents because of their remarkable chemical variability. Among the various natural metabolites, flavonoids are secondary metabolites that are extensively present in nature, have potent anti-cancer properties, have few adverse effects, and also show synergistic benefits. Numerous laboratories are diligently investigating the chemistry and biology of novel flavonoid derivatives due to the demand for and value of these drugs. In this survay, we have summarized clinical trials of various flavonoids, molecular pathways against various cancer cell lines and recent updates on the anticancer activity of flavonoid derivatives against various cancer cells synthesized by various methods, more studies are needed to develop the following mentioned flavonoid derivatives as an anticancer drug.
Comprehensive Assessment of the Manufacturability of Products
Authors: Bochkaryov P. Yu. , Korolev R. D. , Bokova L. G.
Published: July 2023

Introduction. The assessment of the manufacturability of products – as a stage of production planning and a key aspect of the development of modern industrial machining systems — is an urgent task of modern mechanical engineering. In this regard, theoretical and practical research on the development of methodological approaches to determining the weight significance of quantitative indicators in assessing the manufacturability of parts is highly relevant. The objective of the presented work was to develop an evaluation method aimed at improving the quality of part processing and the effectiveness of the performance of multiproduct manufacturing systems based on the development of additional quantitative indicators for assessing production manufacturability.

Materials and Methods. To assess the impact of quantitative production indicators associated with time spent during equipment downtime, a model was created. It was aimed at predicting event flows of delivery of batches of parts for manufacturing for a specific operation and flows of processed parts using the queuing theory apparatus. This approach makes it possible to take into account both the design-engineering characteristics of parts, the features of a particular production system, and the emerging manufacturing situation.

Results. The degree of influence of the manufacturability indicators at the level of the process operation was determined by assessing the possible impact on the components when calculating piece-calculation time (Тшт.к.). The interrelations between the manufacturability indicators and expenses for all items of the production cost of part processing (СОП), as well as costs associated with organizational downtime of equipment (Спр.о.i) were established. The degree of influence of the indicators of manufacturability relative to other indicators was determined by using the apparatus of paired comparisons in decision-making in relation to all structural elements of production costs.

Discussion and Conclusion. The approach to the implementation of this design procedure was described, which provided taking into account the composition and capabilities of processing equipment of a particular production and the actual production situation. The developed formalized models make it possible to comprehensively predict the impact of the manufacturability indicators of parts on the performance effectiveness of machining systems during their manufacture.
Predicting the Behavior of Road Users in Rural Areas for Self-Driving Cars
Authors: Ivanov S. A. , Rasheed B.
Published: July 2023

Introduction. The prediction module generates possible future trajectories of dynamic objects that enables a self-driving vehicle to move safely on public roads. However, all modern prediction methods evaluate their performance only under urban conditions and do not consider their applicability to the domain of rural roads. This work examined the adaptability of existing methods to work under rural unstructured conditions and suggested a new, improved approach.

Materials and Methods. As a solution, we propose to use a neural network that includes the following submodules: a graph-based scene encoder, a multimodal trajectory decoder, and a trajectory filtering module. Another proposed feature is to use an adapted loss function that penalizes the network for generating trajectories that go beyond the drivable area. These elements use standard practices for solving the prediction problem and adapting it to the domain of rural roads.

Results. The presented analysis described the basic features of the prediction module in the rural road domain, showed a comparison of popular models, and discussed its applicability to new conditions. The paper describes the new approach that is more adaptive to the considered domain of study. A simulation of the new domain was performed by modifying existing public datasets.

Discussion and Conclusion. Comparison to other popular methods has shown that the proposed approach provides more accurate results. The disadvantages of the proposed approach were also identified and possible solutions were described.
PREDIKSI KELULUSAN SISWA SEKOLAH MENENGAH PERTAMA MENGGUNAKAN MACHINE LEARNING
Authors: Naibaho Agusti Frananda Alfonsus , Zahra Amalia
Published: July 2023

In recent years, there has been a number of students who graduated late at Lubuk Alung 1st State Junior Highschool. This statement is supported by graduation data from Lubuk Alung 1st Satet Junior Highschool. Therefore, it is necessary to predict students’ graduation status to identify which factors influence the student’s graduation, which will also consequently help the school to solve problem more easily. To solve this problem, the researchers predict student graduation based on student graduation information. The attributes used are personal data related to students, student academic data, and data related to the work of the student’s parents. This research retrieved data on student graduation from schools that have been recapitulated. The classification algorithms used to predict students’ graduation are decision tree, random forest, and extreme gradient boosting with grid searchCV and k-fold=5. The prediction accuracy using the random forest algorithm outperforms the others with a value of 99.5%.
KOMPARASI PENGGUNAAN INSTALASI KABEL NETRAL DARI PLN DAN DARI BUMI LANGSUNG PADA BEBAN LISTRIK 300 WATT
Authors: Taufik Taufik
Published: July 2023

Pemakaian energi listrik terutama dalam pengukuran yang teliti dan akurat terhadap besaran-besaran listrik merupakan suatu hal yang sangat penting untuk mendukung operasi-operasi pekerjaan yang dilakukan oleh petugas suatu sistem tenaga listrik. Diantara sekian banyak alat ukur listrik salah satunya adalah kWh meter yang merupakan salah satu alat ukur listrik yang terpenting pada suatu sistem  tenaga listrik, karena kWh meter digunakan sebagai alat ukur untuk  transaksi daya listrik. Agar produsen maupun konsumen tidak dirugikan dalam pemakaian energi listrik, maka kWh meter pada masyarakat maupun industri memegang peranan sangat penting untuk mencatat berapa banyak jumlah energi listrik terpakai dalam per bulan. Prinsip kerja kWh meter berdasarkan induksi yang ditimbulkan oleh suatu medan listrik. Penelitian ini membahas penggunaan kabel netral dari PLN dan dari bumi langsung pada beban listrik 300 Watt. Data penggunaan kabel netral dari PLN dan dari bumi langsung masing-masing diambil per hari pada jam yang sama atau mendekati jam yang sama selama satu bulan. Data diambil melalui eksperimental di Laboratorium Teknik Instalasi Tenaga Listrik Program Studi Teknik Elektro Fakultas Teknik Universitas Muhammadiyah Palembang. Data diambil masing-masing di kWh Meter yang telah dibandingkan dan dianalisa.
SISTEM MONITORING CUACA DAN PERINGATAN BANJIR BERBASIS IOT DENGAN MENGGUNAKAN APLIKASI MIT APP INVENTOR
Authors: Ulum Muh bahrul
Published: July 2023

Bencana Banjir menjadi salah satu fokus perhatian, karena masih banyak menimbulkan kerugian dan korban jiwa. Banjir dapat terjadi akibat meluapnya air, karena itu diperlukan deteksi dini terhadap level air. Menurut dibi.bnpb.go.id terdapat total 3257 bencana banjir di Indonesia pada tahun 2020-2022. Tujuan pembuatan alat Sistem Monitoring Cuaca dan Peringatan Banjir Berbasis IoT Menggunakan Aplikasi Mit App Inventor Untuk membantu masyarakat di berbagai wilayah yang rawan banjir agar dapat memonitoring dan sadar atas ancaman banjir. Mikrokontroler menggunakan Wemos D1 R1 yang sudah ada modul esp 8266 sehingga bisa tersambung ke jaringan internet. Internet of things merupakan teknologi untuk mengirimkan data sensor secara realtime. Penelitian menggunakan 3 jenin sensor berupa sensor ultrasonic yang mampu mendeteksi ketinggian air, sensor hujan mampu menginformasikan cuaca berupa intensitas hujan dari mulai hujan gerimis, hujan sedang dan hujan deras dan sensor dht 11 yang mampu mendeteksi data suhu disekitar. Data yang diperoleh dari ketiga sensor bisa langsung dipantau secara realtime di smartphone dengan menggunkan aplikasi Mit App Inventor. Setelah melakukan uji coba alat mampu memberikan data suhu disekitar alat dan peringatan dini bencana banjir yang di tandai dengan bunyi buzzer dan indikator Led.
RANCANG BANGUN SISTEM PREDIKSI POLA SIDIK JARI MENGGUNAKAN METODE BACKPROPAGATION
Authors: Abdullah Abdullah , Zikrullah Zikrullah , Usman Usman
Published: July 2023

Jaringan syaraf tiruan adalah salah satu metode yang mengadopsi cara kerja otak manusia dalam memecahkan suatu persoalan. Jaringan syaraf tiruan mengenali pola berdasarkan data training sehingga dapat melakukan prediksi terhadap kasus yang belum pernah dipelajari. Pengenalan sidik jari merupakan salah satu masalah yang sulit dalam pengenalan pola, hal tersebut dikarenakan setiap sidik jari seseorang memiliki ciri-ciri yang mirip namun tidak sama dan unik. Oleh karena itu dibutuhkan butuhkan sistem untuk menganalisis dan mengidentifikasi sidik jari seseorang. Penelitian ini bertujuan untuk merancang dan membangun sistem identifikasi sidik jari dengan menerapkan metode backpropagation. Pengembangan sistem terdiri dari perencanaan, analisa, perancangan, implementasi dan pengujian. Data yang digunakan berupa citra sidik jari berukuran 30x20 piksel yang dirubah menjadi data numerik dengan proses pengolahan citra. Data numerik tersebut digunakan sebagai data input pada sistem jaringan syaraf tiruan. Citra yang digunakan sebanyak 180 citra sidik jari, yang terdiri atas 10 kelas, setiap kelas memiliki 10 sampel sidik jari. Pelatihan jaringan menggunakan data sebanyak 120 citra sidik jari dan pengujiannya menggunakan 60 citra sidik jari. Berdasarkan metode holdout diperoleh hasil pengujian dimana 53 citra dapat dikenali dan 7 citra tidak dikenali, dengan demikian diperoleh tingkat akurasi 89,74%.
OTOMATISASI PERTANIAN DENGAN SENSOR SOIL MOISTURE, SENSOR CAHAYA, LED GROW LAMPS, DAN POMPA AIR UNTUK PERTUMBUHAN TANAMAN OPTIMAL
Authors: Al-Jufri Haarisah Yustika Putri , Novianti Ony , Muhammad Ghibran , Adytya Revangga , Pramudhita Agung Nugroho
Published: July 2023

Pengembangan teknologi IoT telah menjadi solusi yang menarik dalam bidang pertanian, terutama dalam konsep pertanian indoor. Pertanian indoor menawarkan alternatif yang ideal untuk menghadapi tantangan cuaca buruk dan perubahan iklim yang tidak dapat diprediksi. Namun, pertumbuhan tanaman dalam ruangan memiliki kelemahan terkait kondisi cahaya yang terbatas. Oleh karena itu, penelitian ini bertujuan untuk merancang perangkat IoT yang terintegrasi, melibatkan sensor soil moisture, sensor cahaya, UV LED grow lamps, dan pompa air, untuk memantau dan mengontrol kelembaban tanah, intensitas cahaya, serta memberikan pencahayaan tambahan yang optimal bagi pertumbuhan tanaman. Diharapkan penerapan teknologi IoT dalam pertanian ini dapat meningkatkan efisiensi penggunaan sumber daya, mengurangi dampak lingkungan, dan menghasilkan pertumbuhan tanaman yang optimal, sehingga mendorong pengembangan sistem pertanian yang lebih efisien, berkelanjutan, dan produktif.
PERANCANGAN SISTEM INFORMASI DAILY CYCLE COUNT (SIDAC) BERBASIS WEB
Authors: Taufik Andi , Ariani Fattya
Published: July 2023

As a business actor in the field of health food and drink manufacturing, companies really need a warehouse as a means of storing their goods or products. This requires a calculation technique to keep the warehouse estimate running well. Basically, companies have used the Warehouse Management System (WMS) starting from receiving goods, storing them, and sending them. Because business processes are growing more and more incoming and outgoing transactions. This causes the need for a daily cycle count in the warehouse is urgently needed, because it is a benchmark for the accuracy of the stock in the warehouse according to or is well maintained or not. Utilization of the Warehouse Management System in the finish good warehouse in the company has not been able to overcome the need for a daily cycle count process as a need to maintain stock accuracy in the Warehouse. Based on these problems, a Daily Cycle Count information system is needed using a local web that can meet existing needs. The results of this study by making a daily cycle count application are able to help with stock accuracy problems in warehouses in finish good warehouses in the context of daily cycle count needs, as evidenced by the existence of a daily cycle count information system, stock accuracy in finish good warehouses can be maintained properly
ADAPTASI FLEKSIBILITAS SISTEM INFORMASI MANAJEMEN PENGELOLAAN RUMAH SUSUN SEDERHANA SEWA (RUSUNAWA) UNIVERSITAS TANJUNGPURA
Authors: Hamida Hamida , Safriadi Novi , Perwitasari Anggi
Published: July 2023

The provision of information at Rusunawa Untan has increased in response to the needs of students for registration and data management. However, the system currently in use is still conventional and ineffective. This research aims to develop a web-based information system to manage registration and data at Rusunawa Untan. This system can send WhatsApp messages to residents and adapt to user needs. The flexibility of the information system is crucial in its development as the business environment is constantly changing. This research explains the development of the flexibility of the information system and the objectives to be achieved. The Object Oriented Analysis Design (OOAD) method is used for needs analysis, UML design, and implementation with PHP and the Laravel framework. The application is tested using black box method and User Acceptance Test (UAT) with 23 respondents. The UAT results show a satisfaction rate of 85.30%, indicating that the application meets expectations. The OOAD method is well implemented, and the application is well-received and able to adapt to changes in business requirements without significant modifications to the system.
PENERAPAN METODE ANALYTICAL HIERARCHY PROCESS PADA SISTEM PENDUKUNG KEPUTUSAN PEMBELIAN SMARTPHONE
Authors: Tuzzahrah Ahzka Nabbilah , Setiyanto Dikky , Cholis Yaspin Andika Muhamad Nur , Jaman Jajam Haerul
Published: July 2023

Pada tahun 2023 ini, kemunculan smartphone terus berkembang dengan spesifikasi yang berbeda-beda hingga membuat pembeli kesulitan untuk memilih yang terbaik sesuai dengan kenginan dan anggaran mereka. Sejalan dengan berkembangnya teknologi, kita dapat memanfaatkan teknologi untuk membantu dalam hal pemilihan seperti ini. Bentuk teknologi yang kini sedang berkembang salah satunya adalah sistem pendukung keputusan dimana dapat membantu pengguna mendapatkan alternatif terbaik dari banyaknnya pilihan alternatif. Dalam penelitian ini, untuk mendapatkan hasil terbaik dari pemilihan smaprthone, maka dirancang sebuah sistem perankingan dengan menggunakan metode AHP dimana hasil akhir yang didapat adalah informasi smartphone terbaik hingga terburuk berdasarkan bobot dan kriterianya.
THE INFLUENCE OF THE SMART-ECONOMY OF THE REGIONS ON THE DEVELOPMENT OF UKRAINIAN COMPETITIVENESS
Authors: Martinovych Pavlo
Published: July 2023

The study is devoted to revealing the economic essence of the smart economy of the region and identifying areas of influence of such specialization on increasing the competitiveness and innovation activity of the region. It is determined that the concept of digital economy development presupposes the relationship between science, education and economy, and in the context of regional development we are talking about the triad "business science-community". According to these relations, the goal of the smart economy is the optimal use of the potential of individual regions and countries through the maximum adaptation of possible areas of science and education in these regions or countries to their specific socio-economic conditions. It is established that the main advantage of systemic development at the regional level is the increase of its competitiveness and innovation activity, as the presence of innovations in the modern globalized world is the main factor of economic growth.

The article reviews the origins of the smart specialization approach in strategic planning at the regional and local levels, which is defined in the "Methodology for developing, monitoring and evaluating the effectiveness of regional development strategies and action plans for their implementation" and the Cabinet of Ministers of November 11, 2015 № 932 "On approval of the Procedure for developing regional development strategies and action plans for their implementation, as well as monitoring and evaluation of the effectiveness of the implementation of these regional strategies and action plans." The author formulates a scientific problem that needs to be solved in the near future, and also gives a general description of the regions of Ukraine as a basis for choosing a smart specialization. It was found that the scientific and methodological support of the processes of smart specialization implementation remains insufficient, there is a lack of both specialized applied research and targeted assistance to specific regions and territorial communities.
STRENGTHENING THE COMPETITIVE ADVANTAGES OF THE COMPANY THROUGH THE PRISM OF SOCIALLY RESPONSIBLE BEHAVIOR
Authors: Bereziuk-Rybak I.R. , Rotte S.V.
Published: July 2023

The role and importance of corporate social responsibility as a tool for forming the company's competitive advantages in modern conditions are researched in the article. Competition as a basic principle of a market economy forces companies to consider the problem of strengthening competitive positions differently.

The role of corporate social responsibility in strengthening the competitive advantage of companies is growing, and the relationship between trust and social activity of business in the face of intensifying international competition is becoming more and more visible. Hypercompetition is a specific feature of the new behavioral paradigm of modern companies in the world, which is caused by the transition from competition to its new aggressive state. Continuous creation of new competitive advantages is the only way for companies to survive in such conditions.

Sustainable competitive advantage in the long run can provide companies with tools of corporate social responsibility. Socially responsible business behavior can significantly affect the company's reputation, image, brand and reflected in sales.

RepTrak methodology from the international consulting company The RepTrak Company includes a system of indicators that can determine the impact of corporate social responsibility on the formation of the company's reputation. The Global RepTrak100 ranking makes it possible to determine which companies have the highest level of corporate reputation and which factors have the greatest influence on it. The RepTrak Pulse Confidence Index is the average ratio of consumers to a company's reputation on a scale from 0 to 100.

Social responsibility is the company's attitude to product quality, consumers, employees, stakeholders, the environment, so it is a significant competitive advantage in business. The Lego Group's competitive advantage is its high level of customer loyalty, and its socially responsible strategy is to launch social and environmental initiatives according to the Global RepTrak100 rating. The Lego Group is an example of a global leader in honesty, ethics, openness and cleanliness of business.
Influencia de la escoria de cobre como material cementicio suplementario en morteros
Authors: Silva Urrego Yimmy Fernando , Vizcaíno Méndez Gabriel Antonio
Published: July 2023

La demanda de cemento Portland (OPC) impacta de gran manera el medio ambiente, debido a la generación de gases de efecto invernadero y el consumo de materias primas no renovables durante su fabricación. Por tal razón, la búsqueda de materiales alternativos para disminuir el consumo de cemento es vital en la búsqueda de la sustentabilidad. Por esta razón, la escoria de cobre (EC) como materia cementicio suplementario (SCM) en la elaboración de morteros con menor contenido de OPC es una opción para generar un ambiente sostenible. Este estudio, investigo la influencia de la EC frente a la trabajabilidad, resistencia a la compresión y resistencia a la flexión a diferentes edades de curado. Morteros con 0%, 10%, 20%, 30%, 40% y 50% de EC como reemplazo parcial de OPC se elaboraron, donde se evidencio una mayor fluidez en los morteros con EC. Las propiedades mecánicas, se vieron afectas de manera monotónica en las primeras edades evaluadas (7, 28 y 90 días), donde los morteros con mayor contenido de EC presentaron la mayor perdida de resistencia. Sin embargo, a los 150 días de curado, la mezcla 10% EC presento una resistencia a la compresión de 43,6 MPa, 7,6% mayor que la mezcla de referencia.
Development and psychometric properties of the transphobia scale among Indian adolescents
Authors: Lonkar Yashwee , Sharma Pushpalata , Janswamy Jyoti , Sachan Ruchi , Kumar Mahendra
Published: July 2023

Background: Most of the studies employed in the concerning area use foreign scales or translated versions for measurement of transphobia. It isreally unfortunate a democratic country like India does not possesses anystandardized scale to measure the transphobia of adolescents.
Purpose: Therefore, this study includes the development and validation of ascale for the assessment of transphobia in Indian adolescents.
Methods: A total 516 students of CBSE school aged 14-16 years were sampled. The items for the preliminary transphobia scale were drawn after interviewing the adolescents, consultation with a reference group and review from existing standardized scales. A total 516 participants were assessed for psychometric properties of the scale. Criterion validity was evaluated by using the ATTMW (attitude toward transgender men and women) Scale.
Results: Exploratory Factor Analysis (EFA) revealed six factors accounting for 65.30% of observed variance. The final 31-item scale contained six factors: Interpersonal Ease, Gender Prejudices, Gender Obstinacy, Human Values, Gender Stereotype and Gender Abuse. Transphobia scale was highly reliable in terms of internal consistency (Cronbach’s alpha 0.927). Criterion validity with the ATTMW was statistically significant.
Conclusion: As the conclusion of the study, the Indian transphobia scale can be used as a reliable and valid tool for the measurement of transphobia for Indian adolescents.
Hubungan antara Kisspeptin-10 dan Preeklamsia Berat
Authors:   Universitas Makassar, Wibowo Dwi Arry , Abdullah Nusratuddin , Sunarno Isharyah , Padjalangi Andi Nursanty , A. Miskad Upik
Published: July 2023

Tujuan: Menganalisis perbandingan ekspresi KISSPEPTIN-10 antara pasien tidak preeklamsia, preeklamsia berat, dan preeklamsia berat dengan komplikasi. Metode: Penelitian ini menggunakan desain kontrol kasus yang dilakukan pada ibu hamil preeklamsia berat dengan dan tanpa komplikasi sebagai kelompok kasus dan ibu hamil tidak preeklamsia berat sebagai kontrol di RSUP dr. Wahidin Sudirohusodo dan rumah sakit jejaring Fakultas Kedokteran Universitas Hasanuddin. Pengambilan sampel dilakukan dengan consecutive sampling. Kriteria inklusi yaitu ibu hamil dengan preeklamsia berat dan preeklamsia berat dengan komplikasi. Kriteria eksklusi yaitu pasien dengan hipertensi kronik, penyakit tiroid, dan penyakit ginjal sebelum kehamilan dan plasenta previa. Ekspresi KISSPEPTIN-10 diukur secara imunohistokimia dari plasenta saat melahirkan. Data dianalisis dengan uji chi square dan uji Kruskal Wallis. Data dianalisis dengan program SPSS. Hasil: Hasil ini diperoleh 88 subyek penelitian yang terdiri atas 30 pasien kelompok tidak preeklamsia, 30 pasien kelompok preeklamsia berat dan 28 pasien kelompok preeklamsia berat dengan komplikasi. Ekspresi KISSPEPTIN-10 berbeda signifikan antara kelompok tidak preeklamsia berat, preeklamsia berat, dan preeklamsia berat dengan komplikasi (p<0,05). Kesimpulan: Semakin tinggi ekspresi KISSPEPTIN-10 sejalan dengan semakin beratnya derajat preeklamsia berat.
Manajemen Jangka Panjang Endometriosis: Dapatkah Progestin Menjadi Andalan?
Authors:   Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran/RSUP. Dr. Hasan Sadikin Bandung, Bayuaji Hartanto
Published: July 2023

https://www.obgynia.com/obgyn/index.php/obgynia/article/view/527
Trayectorias de trabajo en México: jornadas prolongadas y cuidados intensos
Authors: Castro Méndez Nina
Published: July 2023

El tiempo es un recurso finito. La distribución de éste en el trabajo remunerado y el trabajo de cuidados se ha explorado poco desde una perspectiva longitudinal. El objetivo de esta investigación es analizar los patrones que emergen al considerar las jornadas del trabajo remunerado, distinguiendo por duración (no se posee una jornada a cambio de un pago, jornada a tiempo parcial, a tiempo completo o por tiempo prolongado), y las etapas en el curso de vida (sin hijos, con hijos menores de 6 años y con hijos de 6 años y más) para las mujeres y los hombres entrevistados por la Encuesta Demográfica Retrospectiva de 2017; además, señalar el efecto de la intersección de desigualdades sexo-genéricas, generacionales y socioeconómicas en la tipología observada. Se utiliza el análisis de secuencias a través del algoritmo de alineación óptima para hombres y mujeres como grupos separados con dinámicas diferenciadas por el género. Como parte de los resultados se encuentra que las jornadas de trabajo remunerado en la segunda mitad del siglo XX se caracterizaron por ser prolongadas para los varones y las mujeres de orígenes sociales medios. Las jornadas prolongadas no permiten que hombres y mujeres dediquen tiempo al trabajo de cuidados y al autocuidado.
Panopticism and Complicity
Authors: Ndumu Ana , Marsh Diana E. , Van Hyning Victoria , Triola Sydney
Published: July 2023

Historically, libraries, archives, and museums—or LAM institutions—have been complicit in enacting state power by surveilling and policing communities. This article broadens previous scholars’ critiques about individual institutions to LAM institutions writ large, drawing connections between these sites and ongoing racist, classist, and oppressive designs. We do so by dialing in on the ethical premise that justifies panoptic systems, utilitarianism, and how the glorification of pragmatism reifies systems of control and oppression. First, we revisit LIS applications of Benthamian and Foucauldian ideas of panoptic power to examine the role of LAM institutions as sites of social enmity. We then describe examples of surveillance and state power as they manifest in contemporary data infrastructure and information practices, showing how LAM institutional fixations with utilitarianism reify the U.S. carceral state through norms such as the aggregation and weaponization of user data and the overreliance on metrics. We argue that such practices are akin to widespread systems of surveillance and criminalization. Finally, we reflect on how LAM workers can combat structures that rely on oppressive assumptions and claims to information authority.
Pre-print first published online February 10, 2023
Reorienting Cash Waqf for Economic Development
Authors: Faiz Abd. Karim , Arwin
Published: July 2023

Cash waqf, an initiative introduced by BWI Parepare City, initially aimed to alleviate post-Covid-19 poverty in the region. However, its implementation has proven ineffective and counterproductive to local economic development. In order to gain a comprehensive understanding of the issue, a qualitative study was conducted, consisting of interviews at the BWI Office and PCNU in Parepare City, to gather relevant data.  The study aimed to provide a description of currency waqf from both a fiqh and positive law perspective, while also conducting a Maqāşid Sharia-centric analysis of the reorientation of cash waqf at BWI Parepare City. The first finding showed that cash waqf involved depositing funds in financial institutions for socioreligious purposes. However, the second finding indicated the issue with the current cash waqf implementation in Parepare City, as it lacked orientation and failed to contribute effectively to economic development. This study discusses the implications of cash waqf in facilitating economic recovery, emphasizing the need for waqf fiqh to align with concepts that genuinely benefit the people and remain adaptable to the prevailing conditions. The aim is to ensure the implementation of cash waqf in a manner that supports economic development and maintains harmony with the present circumstances
The Challenges of Powersharing in Implementing the Good Friday Agreement: Twenty-Five Years of Intermittent Shared Governance
Authors: White Timothy J.
Published: July 2023

The attempts to implement the Good Friday Agreement have often been frustrated by Unionist parties’ reluctance to share power given their discontent with the difficulties in achieving decommissioning and more recently the Northern Ireland Protocol that was part of the Brexit Withdrawal Agreement. Given the continuing difficulties in operationalizing the institutional framework negotiated in 1998, Nationalist and Republican parties, especially Sinn Féin, have begun a discussion on a joint referendum that would bring Irish unification. This paper explores the changing narrative of Northern Ireland politics from peaceful powersharing to a transition toward Irish unity.
Transformation or Truce? Tracing the Decline of “Reconciliation” and Its Consequences for Northern Ireland Since 1998
Authors: Morrow Duncan
Published: July 2023

Reconciliation and consociation were at the core of the Belfast/Good Friday Agreement (BGFA) in 1998. Analysis of the politics of the last 25 years in Northern Ireland (NI), however, reveals that many presumed aspects of reconciliation – integrated education, desegregated living, the disbandment of armed groups, cultural rapprochement, linguistic and cultural diversity, safe and secure shared public space, an approach to the past which puts the suffering of victims at its core – remain unaddressed or are deeply disputed. The article explores how consociational government in Northern Ireland has gradually decayed under pressure from this weakness. Since 2016, reconciliation has been a second-order consideration for the shaping partnership between the United Kingdom (U.K.) and Ireland which made the Agreement possible, leaving the Agreement at risk from the repeated exercise of the veto and dependent on the absence of any alternative, rather than proactive commitment.
Irish Nationalist and Republican Attitudes to the Good Friday Agreement: Sell-Out or Steppingstone?
Authors: McGlinchey Marisa
Published: July 2023

This article examines attitudes across Irish republicanism and nationalism to the 1998 Good Friday Agreement (GFA). The research draws on qualitative interviews conducted between 2009–2018, throughout the nationalist and republican spectrum, charting evolving attitudes across this green base. Interviewees include GFA negotiators, including the SDLP, a key architect of the Agreement, and Sinn Féin, the party that went on to claim ownership of the GFA. Interviews were also conducted with dissident Irish republicans who have never accepted the GFA. This article puts a particular focus on nationalist and republican attitudes to armed actions in pursuit of Irish unity. Further, it examines attitudes across the Irish republican/nationalist spectrum to a potential border-poll, resulting from the central principle of the GFA (consent); and analyses positions on the required 50 % plus one for Irish unity.
Contested Spaces and Everyday Peace Politics in Northern Ireland
Authors: Brennan Seán , Marijan Branka
Published: July 2023

In 2022, the United Kingdom downgraded the security threat in Northern Ireland from “severe” to “substantial”, first set in 2010. The latter means that an attack is likely but not highly likely. For many analysts and political observers, the twenty-five years of peace that followed the signing of the Belfast/Good Friday Agreement (B/GFA) though interspersed with periods of political stalemate, have led to an overall external sense the conflict has ended. This downgrading of the security threat in Northern Ireland appears to confirm this sense of a settled peace. Still, the type of peace that has been achieved, and particularly the political dynamics regarding contentious spatial issues, continue to shape the quality of peace experienced by the local population. In turn, it is precisely this everyday quality of peace that reflects the real success, or failure, of various peacebuilding efforts as such practices produce the empirical evidence of sustainable reconciliation or continue sectarian divisions in a post-conflict space.
Marginalized Voices and the Good Friday Agreement: Inclusion and the Northern Ireland Peace Process
Authors: Mizzi Robert C. , Byrne Seán , Sheppard-Luangkhot Tara , Hansen Nancy
Published: July 2023

This article explores building transnational queer and disabilities communities, disability-queer peace, and disability-queer activism in post-peace accord Northern Ireland (NI). Through in-person and virtual interviews with activists, staff, and leaders who are disabled, queer, and/or in allyship, it became clear in the data that respondents were ashamed, frustrated, and sad that ableism and queerphobia continues in NI. Attacks on disabled and LGBTQIA+ people have escalated as a result of the Brexit fallout and the COVID-19 pandemic that negatively impacted marginalized communities that are targeted by legal exclusion, discriminatory, and hateful practices as well as structural and interpersonal violence. Dialogue, diversity, and inclusive practices and policies and a political system that benefits all NI citizens are crucial to building sustainable peace in NI.
Artesanos de Paz: Promoting Everyday Peace-building among Children and Youth through a Participatory Theatre-based Intervention in Colombia: Lessons for Northern Ireland
Authors: O’Sullivan Cadhla
Published: July 2023

There is increasing attention being drawn from the literature to build peace from the ground up. Critical studies expose the inadequacies of liberal peace regimes advocating for an everyday peace in the peacebuilding regime. Peacebuilding is future orientated and thus calls for a focus on children and youth in the research. Qualitative, participatory, arts-based methods allow for creativity, hope, and change for the future. This article presents qualitative data from 75 children and youth between the ages of 7 and 18 across three urban settings in the post conflict state of Colombia, highlighting potential implications for Northern Ireland 25 years on from the Good Friday Agreement.
Possibilities of CT in the diagnosis of pulmonary aspergillosis in patients with COVID-19 (literature review)
Authors: Nay Myo Tun , Yudin A. L. , Abovich Y. A.
Published: July 2023

Aim: to analyze the latest research in the field of CT diagnostics of pulmonary aspergillosis in patients with COVID-19 according to domestic and foreign literature.

Results. Pulmonary aspergillosis is one of the most common life-threatening fungal diseases that is caused by inhalation of Aspergillus mold spores and affects all parts of the respiratory system. In recent years, there has been a sharp increase in cases of invasive mycotic processes. During the COVID-19 pandemic, according to a number of authors, the incidence of pulmonary aspergillosis reached 34.4%, and the mortality rate was 74%. The World Health Organization calls for “minimizing the disproportionate use of corticosteroids and antibiotics for mild and moderate cases”. She explained that corticosteroids in severe cases do save lives, but their massive use can cause fungal infections. This complication is increasingly common in patients after corticosteroid and antibiotic therapy, with immunodeficiency states, as well as those treated in intensive care units. The COVID-19 pandemic has created additional challenges in the diagnosis, treatment and prevention of fungal complications. The clinical and radiographic features of fungal infections are largely similar to typical pulmonary manifestations of COVID-19. A comparative analysis of CT signs of various forms of pulmonary aspergillosis before and during the COVID-19 pandemic was carried out according to the literature. The main CT symptoms of mycotic lung lesions among patients who have undergone COVID-19 have been identified. Currently, computed tomography is crucial, first of all, to detect and monitor complications of COVID-19, including the addition of a secondary fungal infection.

Conclusion. To make a conclusion about mycosis in the early stages, special vigilance and high qualification of the radiologist are required, which in turn will contribute to the timely appointment of antifungal therapy, which will reduce morbidity and mortality.
Critical Literacy and Climate Change
Authors: Hartzell Abby
Published: July 2023

This 11th Grade Language & Literature Climate Mini-Unit was created to develop 11th grade students’ climate and critical literacy skills through analysis and discussion of multi-genre climate texts. The unit covers several state standards related to media literacy in reading and inquiry-based writing. After completing this unit, students will understand the widespread, inequitable impacts of climate change and are equipped to engage with climate-related media and literature through a critical lens.