bluuebunny/crossref_metadata_2025 huggingface dataset:
ChemInform Abstract: Hydrothermal Synthesis and Magnetic Behaviour of β‐Li3VF6 and Na3VF6.
Authors: Ge Lei , Yuan Long , Huang Keke , Feng Wenchun , Fang Hairui , Feng Shouhua
Published: September 2015

Single crystals of β‐Li3VF6 (I) and Na3VF6 (II) are obtained by hydrothermal reaction of stoichiometric amounts of NH4VO3, NH4HF2, LiCl (NaCl), and fumaric acid (pH 4—6, autoclave, 240 °C, 24 h) without the need for HF.
ChemInform Abstract: A Keggin‐Type Structure Expanded by an Eight‐Membered Ring of Alternating Edge‐Sharing VO5 and VO6 Polyhedra: Solvothermal Synthesis, Crystal Structure, and Magnetic Properties.
Authors: Rasmussen Maren , Naether Christian , van Leusen Jan , Koegerler Paul , Bensch Wolfgang
Published: September 2015

(trenH)2(trenH2)2 [W4V13O44]·≈11H2O (tren: tris(2‐aminoethyl)‐amine) is prepared under solvothermal conditions by reacting NH4VO3 and WO3 (molar ratio of 1:1.6) in a solution of tren in H2O at pH ≈12 (sealed glass tubes, 130 °C, 3 d, 65% yield based on WO3).
ChemInform Abstract: Crystal Growth and Structure of the Barium Chloride Nitridotantalate(V) Ba3Cl2TaN3.
Authors: Blaschkowski Bjoern , Duerr Oliver , Reckeweg Olaf , Schleid Thomas
Published: September 2015

Transparent, light yellow single crystals of the new title compound are obtained from the reaction of Ba(N3)Cl with the container wall of arc‐welded Ta ampules (900 °C, 4 d).
ChemInform Abstract: Perovskite‐Type Solid Solution SrMo1‐xWx(O, N)3 Oxynitrides: Synthesis, Structure, and Magnetic Properties.
Authors: Li Wenjie , Gurlo Aleksander , Riedel Ralf , Ionescu Emanuel
Published: September 2015

Solid solutions SrMo1‐xWxO4 with 0.05 ≤ x ≤ 0.95 are solvothermally synthesized from mixtures of Sr(NO3)2, Na2MoO4, and Na2WO4 in en (autoclave, 200 °C, 24 h).
ChemInform Abstract: Large Scale Synthesis and Formation Mechanism of Highly Magnetic and Stable Iron Nitride (ε‐Fe3N) Nanoparticles.
Authors: K. Rohith Vinod , Saravanan P. , Sakar M. , Vinod V. T. P. , Cernik Miroslav , Balakumar S.
Published: September 2015

ε‐Fe3N magnetic nanospheres of an average 45 nm size are prepared by nitriding Fe nanoparticles with gaseous NH3 (alumina boat, 650 °C, 4 h).
ChemInform Abstract: A New Type of Ferrocene‐Based Phosphine‐tert‐Butylsulfinamide Ligand: Synthesis and Application in Asymmetric Catalysis.
Authors: Ma Jiangwei , Li Chuang , Zhang Dongxu , Lei Yang , Li Muqiong , Jiang Ru , Chen Weiping
Published: September 2015

A new ferrocene‐based catalyst (FER) for the asymmetric alkylation of disubstituted linear substrates [symmetrical (I), unsymmetrical (VI)], and unhindered cyclic substrates (IV) is developed.
ChemInform Abstract: Michael Addition of Soft Carbon Nucleophiles to Alkylidene Isoxazol‐5‐ones: A Divergent Entry to β‐Branched Carbonyl Compounds.
Authors: Capreti Naylil M. R. , Jurberg Igor D.
Published: September 2015

β‐Branched and linear carbonyl compounds are synthesized via Michael addition of soft carbon nucleophiles to various alkylidene isoxazol‐5‐ones followed by either a nitrosative cleavage leading to the corresponding β‐branched alkynyl ketones [→ (IV),(VII),(X),(XIV)] or a decarboxylative transformation leading to the corresponding ketones (XVI).
ChemInform Abstract: Synthesis and Molecular Structure Characterization of Novel 1,6‐Diazahexatrienes.
Authors: Yuan Libin , Fan Qiangwen , Yan Hong , Song Xiuqing
Published: September 2015

Sodium carbonate needs to be activated (heated at 100°C in a hot air‐oven) prior to use.
ChemInform Abstract: An Efficient Aqueous Phase Synthesis of Benzimidazoles/Benzothiazoles in the Presence of β‐Cyclodextrin.
Authors: Katla Ramesh , Chowrasia Rakhi , Manjari Padma Sunitha , Domingues Nelson Luis C.
Published: September 2015

The title compounds are synthesized in water under neutral conditions by the reaction of aromatic aldehydes with 2‐amino thiophenol (I) or o‐phenylenediamine (IV) mediated by β‐cyclodextrin in high yields.
ChemInform Abstract: Selective Oxidation of Benzyl Alcohols to Aldehydes with a Salophen Copper(II) Complex and tert‐Butyl Hydroperoxide at Room Temperature.
Authors: Chen Tingting , Cai Chun
Published: September 2015

The reaction proceeds without any overoxidation.
ChemInform Abstract: Cyclic Bent Allene Hydrido‐Carbonyl Complexes of Ruthenium: Highly Active Catalysts for Hydrogenation of Olefins.
Authors: Pranckevicius Conor , Fan Louie , Stephan Douglas W.
Published: September 2015

A new family of ruthenium complexes is synthesized and evaluated for their catalytic activity in the hydrogenation of unactivated olefins.
ChemInform Abstract: Palladium(0)/PAr3‐Catalyzed Intermolecular Amination of C(sp3)—H Bonds: Synthesis of β‐Amino Acids.
Authors: He Jian , Shigenari Toshihiko , Yu Jin‐Quan
Published: September 2015

These reactions proceeds via oxidative addition of the protected hydroxylamine to the catalyst and subsequent C—H bond cleavage.
ChemInform Abstract: Palladium Supported on Silica—Chitosan Hybrid Material (Pd‐CS@SiO2) for Suzuki—Miyaura and Mizoroki—Heck Cross‐Coupling Reactions.
Authors: Jadhav Sanjay , Kumbhar Arjun , Salunkhe Rajashri
Published: September 2015

The catalyst is robust, recoverable, and recyclable without significant loss of its activity.
ChemInform Abstract: Simple and Expeditious Pinacol Coupling of Non Usual α,β‐Unsaturated Carbonyl Compounds in Water.
Authors: Billamboz Muriel , Sotto Nicolas , Chevrin‐Villette Carole , Len Christophe
Published: September 2015

using zinc as cheap and readily available reductant
ChemInform Abstract: Biphilic Organophosphorus Catalysis: Regioselective Reductive Transposition of Allylic Bromides via PIII/PV Redox Cycling.
Authors: Reichl Kyle D. , Dunn Nicole L. , Fastuca Nicholas J. , Radosevich Alexander T.
Published: September 2015

The reductive transposition of primary allylic halides is catalyzed by a biphilic organophosphorus catalyst.
ChemInform Abstract: Well‐Defined Copper(I) Fluoroalkoxide Complexes for Trifluoroethoxylation of Aryl and Heteroaryl Bromides.
Authors: Huang Ronglu , Huang Yangjie , Lin Xiaoxi , Rong Mingguang , Weng Zhiqiang
Published: September 2015

Phenanthroline ligand‐supported copper(I) fluoroalkoxide complexes bearing a trifluoroethoxy, a pentafluoropropoxy or a tetrafluoropropoxy substituent are prepared and applied in the scalable synthesis of fluoroalkyl (hetero)aryl ethers.
ChemInform Abstract: One‐Pot Transformation of Esters to Analytically Pure Ketones: Methodology and Application in Process Development.
Authors: Prosser Anthony R. , Liotta Dennis C.
Published: September 2015

The robust and scalable title method is based on the reaction between methyl 1‐benzylpiperidine‐4‐carboxylate and primary Grignard reagents, but fails using secondary Grignard reagents.
ChemInform Abstract: Ruthenium‐Catalyzed Direct N‐Formylation of Lactams with Paraformaldehyde.
Authors: Lee Hoseong , Kang Byungjun , Lee Sang‐Ick , Hong Soon Hyeok
Published: September 2015

Lactams are directly converted into N‐formylimides catalyzed with Shvo′s catalyst generating hydrogen as the only by‐product.
ChemInform Abstract: Copper(I)‐Mediated Direct Trifluoromethylthiolation of Allylic Halides with Elemental Sulfur and (Trifluoromethyl)trimethylsilane.
Authors: Li Jue , Wang Peiqiang , Xie Fei‐Fei , Yang Xi‐Gang , Song Xiao‐Nan , Chen Wei‐Dong , Ren Jiangmeng , Zeng Bu‐Bing
Published: September 2015

A convenient process is described to convert a variety of allylic chlorides into allylic trifluoromethyl thioethers.
ChemInform Abstract: Conditions for a Rh(I)‐Catalyzed [2 + 2 + 1] Cycloaddition Reaction with Methyl Substituted Allenes and Alkynes.
Authors: Wells Sarah M. , Brummond Kay M.
Published: September 2015

Rhodium‐catalyzed cyclocarbonylation reactions of substrates (I) and (IV) are achieved under high dilution conditions to afford bicyclododecane derivatives including products possessing a 6,12‐guaianolide framework.
ChemInform Abstract: Enantioselective Synthesis of Bicyclo[3.n.1]alkanes by Chiral Phosphoric Acid‐Catalyzed Desymmetrizing Michael Cyclizations.
Authors: Burns Alan R. , Madec Amael G. E. , Low Darryl W. , Roy Iain D. , Lam Hon Wai
Published: September 2015

of 2,2‐disubstituted cyclic 1,3‐diketones containing a tethered electron‐deficient alkene
ChemInform Abstract: AlCl3‐Catalyzed Ring Expansion Cascades of Bicyclic Cyclobutenamides Involving Highly Strained cis,trans‐Cycloheptadienone Intermediates.
Authors: Wang Xiao‐Na , Krenske Elizabeth H. , Johnston Ryne C. , Houk K. N. , Hsung Richard P.
Published: September 2015

The first experimental evidence for the generation of highly strained cis,trans‐cycloheptadienones as intermediates in the Lewis acid‐catalyzed rearrangement of 4,5‐ and 4,6‐fused cyclobutenamides is given.
ChemInform Abstract: A Novel Approach to N′,N′‐Diarylhydrazides from N′‐Arylhydrazides.
Authors: Yu Jun , Wang Shuguang , Wen Jianming , Wang Jian , Li Jing‐Hua
Published: September 2015

A novel method for the N‐arylation of monoarylhydrazides via aerobic oxidation under mild conditions is presented.
ChemInform Abstract: Asymmetric Hydrosilylation of Aromatic Ketones Catalyzed by an Economical and Effective Copper‐Diphosphine Catalytic System in Air.
Authors: Liang Minting , Xia Xiaofeng , Liu Xiang , Li Hexing
Published: September 2015

(R)‐1‐Arylethanols (II) are synthesized with high yields and enantioselectivities using an efficient catalyst system in situ generated from Cu(OAc)2·H2O and (R)‐BINAP as ligand with the non‐toxic reducing agent PMHS in air atmosphere and at room temperature.
ChemInform Abstract: From Simple Organobromides or Olefins to Highly Value‐Added Bromohydrins: A Versatile Performance of Dimethyl Sulfoxide.
Authors: Song Song , Huang Xiaoqiang , Liang Yu‐Feng , Tang Conghui , Li Xinwei , Jiao Ning
Published: September 2015

Secondary bromides or olefins are efficiently converted to highly value‐added bromohydrins using DMSO as cheap and common solvent, essential oxidant, and also as oxygen source.
ChemInform Abstract: Cationic Palladium(II) Complexes as Catalysts for the Oxidation of Terminal Olefins to Methyl Ketones Using Hydrogen Peroxide.
Authors: Cao Qun , Bailie David S. , Fu Runzhong , Muldoon Mark J.
Published: September 2015

Terminal olefins (I) are oxidized to their corresponding methyl ketones (II) using ligated Pd(II) complexes as catalyst and aqueous H2O2 as sustainable and readily available oxidant.
ChemInform Abstract: Palladium‐Catalyzed Heck Coupling of Arylhydrazines via C—NHNH2 Bond Activation.
Authors: Liu Jin‐Biao , Chen Fu‐Jiao , Liu Na , Hu Jiang
Published: September 2015

Various functionalized styrene derivatives are efficiently obtained under mild reaction conditions by a novel palladium‐catalyzed Heck coupling reaction of commercially available arylhydrazines with olefins using inexpensive and manageable TosCl as activation agent.
ChemInform Abstract: Iron‐Mediated C—H Coupling of Arenes and Unactivated Terminal Alkenes Directed by Sulfur.
Authors: Cavanagh Craig W. , Aukland Miles H. , Hennessy Alan , Procter David J.
Published: September 2015

FeCl3‐Mediated coupling of alkenes to arenes in ortho‐position of arylsulfanyl group give the corresponding β‐chloroalkyl derivatives.
ChemInform Abstract: Rhodium‐Catalyzed Denitrogenative Thioacetalization of N‐Sulfonyl‐1,2,3‐triazoles with Disulfides: An Entry to Diverse Transformation of Terminal Alkynes.
Authors: Zhang Hao , Wang Hui , Yang Haijun , Fu Hua
Published: September 2015

Click chemistry‐derived N‐sulfonyl‐1,2,3‐triazoles can be efficiently transformed into thioacetals via rhodium‐catalyzed reaction with diaryl sulfides followed by either reduction or hydrolysis.
ChemInform Abstract: Copper‐Catalyzed Cross‐Couplings of Arylboronate Esters with Aryl and Heteroaryl Iodides and Bromides.
Authors: Gurung Santosh K. , Thapa Surendra , Shrestha Bijay , Giri Ramesh
Published: September 2015

The title reaction requires a P,N‐bidentate ligand for aryl—aryl coupling reaction whereas, aryl—hetaryl coupling proceeds without any external ligand.
ChemInform Abstract: An ortho‐Directed C—H Borylation/Suzuki Coupling Sequence in the Formation of Biphenylbenzylic Amines.
Authors: Hale Lillian V. A. , Emmerson David G. , Ling Emma F. , Roering Andrew J. , Ringgold Marissa A. , Clark Timothy B.
Published: September 2015

Indium catalyzed borylation of benzylic amines provides the corresponding boronate ester intermediates.
ChemInform Abstract: A Nickel‐Catalyzed α,β‐Coupling of Saturated Ketones.
Authors: Tutkowski Brandon M. , Grigalunas Michael , Wiest Olaf , Helquist Paul
Published: September 2015

Optimized reaction conditions are developed for an unanticipated type of coupling reaction of electron‐rich aromatic ketones to form 1,5‐diketones.
ChemInform Abstract: Enantioselective Nazarov Cyclization Catalyzed by a Cinchona Alkaloid Derivative.
Authors: Huang Yu‐Wen , Frontier Alison J.
Published: September 2015

Diene‐diones of type (I) undergo an 1,6‐addition/Nazarov cyclization/elimination reaction in the presence of Hatkeyama′s chiral cinchona alkaloid catalyst to give functionalized cyclopentenones in good yields and enantioselectivities.
ChemInform Abstract: Lewis Acid Catalyzed Nazarov Type Cyclization for the Synthesis of a Substituted Indane Framework: Total Synthesis of (.+‐.)‐Mutisianthol.
Authors: Dethe Dattatraya H. , Boda Raghavender , Murhade Ganesh M.
Published: September 2015

Nazaroc type cyclization of substrate (I) affords indane derivative (II) which is further converted into racemic mutisianthol (III) and epi‐mutisianthol (IV).
ChemInform Abstract: Convenient Synthesis of Functionalized Spiro[indoline‐3,2′‐pyrrolizines] or Spiro[indoline‐3,3′‐pyrrolidines] via Multicomponent Reactions.
Authors: Sun Jing , Chen Liang , Gong Hui , Yan Chao‐Guo
Published: September 2015

An uncatalyzed three‐component reaction of 3‐methylene oxindoles, α‐amino acids, and dialkyl acetylenedicarboxylates proceeds with sequential generation of active α,β‐enamino ester and azomethine ylide, followed by 1,3‐dipolar cycloaddition reaction.
ChemInform Abstract: 1,3‐Dipolar Cycloaddition Reactions of Phthalic Anhydrides with an Azomethine Ylide.
Authors: Santos Hugo , Distiller Amy , D'Souza Asha M. , Arnoux Quentin , White Jonathan M. , Meyer Adam G. , Ryan John H.
Published: September 2015

The title process gives cycloadducts of limited stability that decompose at ambient temperature.
ChemInform Abstract: Room Temperature Activation of Aryloxysulfonyl Azides by [Co(II)(TPP)] for Selective Radical Aziridination of Alkenes via Metalloradical Catalysis.
Authors: Subbarayan Velusamy , Jin Li‐Mei , Cui Xin , Zhang X. Peter
Published: September 2015

This operationally simple process proceeds under mild conditions to give various N‐aryloxysulfonyl aziridines generating N2 as the only by‐product.
ChemInform Abstract: A Convergent Route to Substituted Azetidines and to Boc‐Protected 4‐Aminomethylpyrroles.
Authors: Han Songzhe , Zard Samir Z.
Published: September 2015

The modular approach is based on the radical addition of xanthates bearing various functional groups to N‐Boc‐protected azetidine and reductive dexanthylation of the latter to afford a diverse range of azetidine building blocks.
ChemInform Abstract: Benzannulation of Triynes to Generate Functionalized Arenes by Spontaneous Incorporation of Nucleophiles.
Authors: Karmakar Rajdip , Yun Sang Young , Chen Jiajia , Xia Yuanzhi , Lee Daesung
Published: September 2015

The novel benzannulation reaction is assumed to proceed via an allene‐enyne intermediate generated by an Alder‐ene process in the first step.
ChemInform Abstract: Preparation of Acylthiophenes by Iron(III) Chloride Catalyzed Reactions of Tris(2‐thienyl)stibanes with Acyl Chlorides.
Authors: Kakusawa Naoki , Nakagawa Yoshie , Toshima Yutarou , Yasuike Shuji , Kurita Jyoji
Published: September 2015

The reaction can also be performed under neat and aerobic conditions.
ChemInform Abstract: Broensted Acid‐Catalyzed Intramolecular Nucleophilic Substitution of the Hydroxyl Group in Stereogenic Alcohols with Chirality Transfer.
Authors: Bunrit Anon , Dahlstrand Christian , Olsson Sandra K. , Srifa Pemikar , Huang Genping , Orthaber Andreas , Sjoeberg Per J. R. , Biswas Srijit , Himo Fahmi , Samec Joseph S. M.
Published: September 2015

The H3PO2‐catalyzed cyclization of enantioenriched γ‐nucleophile functionalized alcohols to saturated 5‐membered O‐, S‐, and N‐heterocycles is presented.
ChemInform Abstract: Studies on the Asymmetric Synthesis of Pandamarilactonines: An Unexpected syn‐Selective Vinylogous Mannich Reaction of N‐tert‐Butanesulfinimines.
Authors: Ye Jian‐Liang , Zhang Yu‐Feng , Liu Yang , Zhang Jin‐Yuan , Ruan Yuan‐Ping , Huang Pei‐Qiang
Published: September 2015

The C‐3 methyl group of substrate (II) is crucial for the unanticipated syn‐diastereoselectivity in vinylogous Mannich reactions with optically active sulfimines.
ChemInform Abstract: Synthesis of 2‐Arylpyrroles via Catalytic Dehydrogenation of 2‐Aryl‐1‐pyrrolines in the Presence of Palladium‐Supported on Alumina.
Authors: Figueira Claudia A. , Lopes Patricia S. , Gomes Pedro T.
Published: September 2015

The dehydrogenation of arylated pyrrolines with alumina‐supported palladium as the catalyst is studied.
ChemInform Abstract: C—H Alkenylations with Alkenyl Acetates, Phosphates, Carbonates, and Carbamates by Cobalt Catalysis at 23 °C.
Authors: Moselage Marc , Sauermann Nicolas , Richter Sven C. , Ackermann Lutz
Published: September 2015

The regioselective C‐H alkenylation of N‐(2‐pyrimidyl) or N‐(2‐pyridyl) substituted indoles using a variety of O‐substituted cyclohexanol derivatives in the presence of CoI2 and a NHC‐carbene is presented.
ChemInform Abstract: Facile Synthesis of Isoindolinones via Rh(III)‐Catalyzed One‐Pot Reaction of Benzamides, Ketones, and Hydrazines.
Authors: Zhang Yan , Wang Dahai , Cui Sunliang
Published: September 2015

Various ketones are transformed into donor‐donor diazo compounds, which sequentially incorporate benzamides under Rh(III) catalysis to generate N‐substituted quaternary isoindolinones.
ChemInform Abstract: Synthesis of New 3‐[(Alkylthio)methyl]‐1‐hydroxy‐2‐phenylindoles.
Authors: Lee Sang Hyup , Kim Hyejin , Park Yeon Kyeong , Cho Hyunsung
Published: September 2015

A one‐pot protocol for the synthesis of 1‐hydroxyindoles from conjugated nitroketones with thiol nucleophiles is presented.
ChemInform Abstract: An Aluminum Porphyrin Complex with High Activity and Selectivity for Cyclic Carbonate Synthesis
Authors: Qin Yusheng , Guo Hongchen , Sheng Xingfeng , Wang Xianhong , Wang Fosong
Published: September 2015

from epoxides and CO2
ChemInform Abstract: Pd‐Catalyzed Asymmetric Hydrogenation of Fluorinated Aromatic Pyrazol‐5‐ols via Capture of Active Tautomers.
Authors: Chen Zhang‐Pei , Chen Mu‐Wang , Shi Lei , Yu Chang‐Bin , Zhou Yong‐Gui
Published: September 2015

A wide range of 2,5‐ and 2,4,5‐trisubstituted pyrazolidinones are synthesized via Broensted acid promoted tautomerization of pyrazol‐5‐ols and Pd‐catalyzed asymmetric hydrogenation of the active tautomer.
ChemInform Abstract: Lewis Acid Mediated Diastereoselective Intermolecular Radical Addition/Trapping with Pyrazolidinone Acrylimides.
Authors: Ma Gaoyuan , Fujita Takehiro , Sibi Mukund P.
Published: September 2015

A facile one‐pot procedure for the radical conjugate addition of alkyl iodides to amides bearing a new pyrazolidinone chiral auxiliary and subsequent diastereoselective trapping of the intermediate radical by an allyl group is developed.
ChemInform Abstract: In situ Generation of Difluoromethyl Diazomethane for [3 + 2] Cycloadditions with Alkynes.
Authors: Mykhailiuk Pavel K.
Published: September 2015

Difluoromethyl diazomethane is generated in situ and utilized in [3 + 2] cycloadditions for the first time.
ChemInform Abstract: Synthesis of 2‐Bromoimidazoles from Alkynes, N‐Sulfonylazides, and Bromocyanides.
Authors: Lee Eunsook , Ryu Taekyu , Shin Eunji , Son Jeong‐Yu , Choi Wonseok , Lee Phil Ho
Published: September 2015

The title compounds are obtained by Rh‐catalyzed cyclization of triazoles with bromocyanide (II).
ChemInform Abstract: Preparation and Diels—Alder Reactions of 1′‐Heterosubstituted Vinylimidazoles.
Authors: Ray Abhisek , Mukherjee Sabuj , Das Jayanta , Bhandari Manoj K. , Du Hongwang , Yousufuddin Muhammed , Lovely Carl J.
Published: September 2015

The preparation of halogen, silyl or stannyl substituted vinylimidazoles is developed and their Diels—Alder reaction with N‐phenylmaleimide is found to give tricyclic products, however with slightly different structural results.
ChemInform Abstract: Nickel‐Catalyzed Decarboxylative Arylation of Azoles with Perfluoro‐ and Nitrobenzoates.
Authors: Crawford Jennifer M. , Shelton Kyle E. , Reeves Emily K. , Sadarananda Bryce K. , Kalyani Dipannita
Published: September 2015

The title process allows the synthesis of 2‐arylated benzoxazoles.
ChemInform Abstract: A Straightforward Metal‐Free Synthesis of 2‐Substituted Thiazolines in Air.
Authors: Trose Michael , Lazreg Faima , Lesieur Mathieu , Cazin Catherine S. J.
Published: September 2015

The title thiazolines (III) (25 examples) are obtained by base‐catalyzed reaction of various nitriles (I) and cysteamine hydrochloride (II) under solvent‐free conditions.
ChemInform Abstract: A Facile Approach to Synthesize 3,5‐Disubstituted‐1,2,4‐oxadiazoles via Copper‐Catalyzed‐Cascade Annulation of Amidines and Methylarenes.
Authors: Guo Wei , Huang Kunbo , Ji Fanghua , Wu Wanqing , Jiang Huanfeng
Published: September 2015

A novel straightforward synthesis of disubstituted‐1,2,4‐oxadiazoles by the copper‐catalyzed reaction of amidines with methylarenes is reported.
ChemInform Abstract: One‐Pot Multicomponent Synthesis of Highly Functionalized Bio‐Active Pyrano[2,3‐c]pyrazole and Benzylpyrazolyl Coumarin Derivatives Using ZrO2 Nanoparticles as a Reusable Catalyst.
Authors: Saha Arijit , Payra Soumen , Banerjee Subhash
Published: September 2015

The catalyst is reusable up to ten cycles without loss of catalytic activity and its tetragonal plane.
ChemInform Abstract: Copper(I) Iodide Supported Synthesis of Coumarin‐ and Quinolone‐Annulated 2‐Aminothiazoles.
Authors: Paul Satya B. , Majumdar K. C. , Anwar Siddique , Choudhury Sudip
Published: September 2015

An efficient, low‐hazard protocol for the reaction of coumarin and quinolone derivatives with phenylthiocyanates is presented.
ChemInform Abstract: ortho‐Quinone Methides as Reactive Intermediates in Asymmetric Broensted Acid Catalyzed Cycloadditions with Unactivated Alkenes by Exclusive Activation of the Electrophile.
Authors: Hsiao Chien‐Chi , Raja Sadiya , Liao Hsuan‐Hung , Atodiresei Iuliana , Rueping Magnus
Published: September 2015

The [4 + 2]‐hetero‐Diels—Alder reaction tolerates a broad range of alkenes including 1‐substituted and acyclic as well as cyclic 1,2‐disubstituted ones which react according to the title reaction to form chromanes with two stereocenters with excellent diastereoselectivity and enantioselectivity.
ChemInform Abstract: Radical 5‐exo Cyclization of Alkynoates with 2‐Oxoacetic Acids for Synthesis of 3‐Acylcoumarins.
Authors: Liu Tong , Ding Qiuping , Zong Qianshou , Qiu Guanyinsheng
Published: September 2015

The protocol represents the first example for coumarin synthesis from alkynoates through decarboxylative radical 5‐exo annulation and ester migration.
ChemInform Abstract: Sc(OTf)3‐Catalyzed [3 + 3] Annulation of Cyclopropane 1,1‐Diesters with Mercaptoacetaldehyde: A Facile Strategy for the Synthesis of Tetrahydrothiopyranols.
Authors: Wang Hua‐Peng , Zhang Huan‐Huan , Hu Xiu‐Qin , Xu Peng‐Fei , Luo Yong‐Chun
Published: September 2015

A Sc(OTf)3‐catalyzed formal [3 + 3] cycloaddition of cyclopropane dicarboxylates with mercaptoacetaldehyde is developed to produce tetrahydrothiopyranols in good yields.
ChemInform Abstract: An Environmentally Benign Catalytic Method for Versatile Synthesis of 1,4‐Dihydropyridines via Multicomponent Reactions.
Authors: Cao Shuo , Zhong Shanshan , Hu Changfeng , Wan Jie‐Ping , Wen Chengping
Published: September 2015

Title compounds [(IV) and (VI)] are synthesized through environmentally benign multicomponent reactions in aqueous medium using lactic acid as a green catalyst.
ChemInform Abstract: Chromium(II)‐Catalyzed Amination of N‐Heterocyclic Chlorides with Magnesium Amides.
Authors: Steib Andreas K. , Fernandez Sarah , Kuzmina Olesya M. , Corpet Martin , Gosmini Corinne , Knochel Paul
Published: September 2015

The ligand‐free chromium dichloride‐catalyzed selective amination of mono‐ and dichlorinated pyridines, quinolines, isoquinolines, and quinoxalines with various amines is reported.
ChemInform Abstract: Ni(II)/BINOL‐Catalyzed Alkenylation of Unactivated C(sp3)—H Bonds.
Authors: Liu Yue‐Jin , Zhang Zhuo‐Zhuo , Yan Sheng‐Yi , Liu Yan‐Hua , Shi Bing‐Feng
Published: September 2015

The gained olefins can serve as versatile handles for further preparations.
ChemInform Abstract: Copper‐Catalyzed Cascade Addition Route to 2,3,4‐Trisubstituted Quinoline Derivatives.
Authors: Crifar Cynthia , Doerr Aurelie A. , Lubell William D.
Published: September 2015

The copper‐catalyzed cascade addition of vinylmagnesium bromide on methyl anthranilate without amine protection affords ketone (III) which undergoes the Friedlnder reaction with various ketones to give trisubstituted quinolines.
ChemInform Abstract: Facile Synthesis of Acridines via Pd(0)‐Diphosphine Complex‐Catalyzed Tandem Coupling/Cyclization Protocol.
Authors: Wang Ting‐Jun , Chen Wen‐Wen , Li Yi , Xu Ming‐Hua
Published: September 2015

Cyclization of 2‐bromobenzaldehydes with anilines easily affords a broad range of acridines.
ChemInform Abstract: The α‐Chymotrypsin‐Catalyzed Povarov Reaction: One‐Pot Synthesis of Tetrahydroquinoline Derivatives.
Authors: Li Ling‐Po , Cai Xin , Xiang Yang , Zhang Yong , Song Jian , Yang Da‐Cheng , Guan Zhi , He Yan‐Hong
Published: September 2015

A wide range of the title compounds (IV)/(V), (VIII)/(IX) are obtained by one‐pot three‐component Povarov reaction using α‐chymotrypsin from bovine pancreas as safe, economical, and eco‐friendly catalyst.
ChemInform Abstract: Modified Multicomponent Biginelli—Atwal Reaction Towards a Straightforward Construction of 5,6‐Dihydropyrimidin‐4‐ones.
Authors: Pair Etienne , Levacher Vincent , Briere Jean‐Francois
Published: September 2015

The title dihydropyrimidinones are synthesized as racemic mixtures or enantiopure diastereomers (IX) by multicomponent Knoevenagel‐aza‐Michael‐cyclocondensation reaction of Meldrum′s acid, isourea derivatives, and various aldehydes.
ChemInform Abstract: Copper‐Powder‐Catalyzed Synthesis of Pyrimidines from β‐Bromo α,β‐Unsaturated Ketones and Amidine Hydrochlorides.
Authors: Jiao Yang , Ho Son Long , Cho Chan Sik
Published: September 2015

The reaction provides a new method for synthesizing pyrimidines starting from readily available ketones and amidine hydrochloride.
ChemInform Abstract: Synthesis of Fused Polyhalogeno‐7a‐hydroxy‐[1,2‐a]indol‐5‐one Derivatives.
Authors: Yu Fu‐Chao , Hao Xiao‐Pan , Lin Xin‐Rong , Yan Sheng‐Jiao , Lin Jun
Published: September 2015

Based on Nenitzescu indole synthesis, the title derivatives [e.g. (III)] are synthesized from heterocyclic ketene aminals [e.g. (I)] and halogenated quinones [e.g. (II)] without catalyst in acetone at room temperature.
ChemInform Abstract: Copper‐Catalyzed Synthesis of Valuable Heterocyclic Compounds Using a Tandem Oxidation Process Approach.
Authors: Jeena Vineet , Sithebe Siphamandla , Robinson Ross S.
Published: September 2015

A series of quinoxaline derivatives, e.
ChemInform Abstract: Highly Regio‐ and Stereoselective Hydrosilylation of Internal Thioalkynes under Mild Conditions.
Authors: Ding Shengtao , Song Li‐Juan , Wang Yong , Zhang Xinhao , Chung Lung Wa , Wu Yun‐Dong , Sun Jianwei
Published: September 2015

The title reaction is based on the addition of sterically congested (Tms‐O)3SiH onto a range of thioalkynes bearing aryl and alkyl substituents endowed with various functional groups.
ChemInform Abstract: A Free Radical Cascade Silylarylation of Activated Alkenes: Highly Selective Activation of the Si—H/C—H Bonds.
Authors: Zhang Lizhi , Liu Dong , Liu Zhong‐Quan
Published: September 2015

The title reaction allows an efficient access to silylated oxindoles.
ChemInform Abstract: Synthesis of Quaternary α‐Hydroxy Phosphonates via Direct Hydroxylation of Phosphonate Compounds.
Authors: Liu Jiyan , Wang Wei , Wang Rui , Gu Lijun
Published: September 2015

Quaternary α‐hydroxy phosphonates (II) are efficiently synthesized by direct hydroxylation reaction of phosphonates (I) under mild conditions.
ChemInform Abstract: A Novel, Rapid and Green Method of Phosphorylation under Ultrasound Irradiation and Catalyst Free Conditions.
Authors: Bouzina Abdeslem , Belhani Billel , Aouf Nour‐Eddine , Berredjem Malika
Published: September 2015

Various N‐acylamines (I), N‐acylaminoester ((S)‐IV), N‐acylaminoalcohols ((S)‐VIII), and N‐acylsulfonamides (X) are efficiently phosphorylated with trialkylphosphite under ultrasound irradiation conditions furnishing corresponding amidophosphonates in high yield.
ChemInform Abstract: Sandensone A, a Novel Sesquiterpenoid from the Formosan Soft Coral Sinularia sandensis
Authors: Cheng Shi‐Yie , Wang Shang‐Kwei , Chen Pei‐Wen , Duh Chang‐Yih
Published: September 2015

isolation, structure elucidation and cytotoxicity
ChemInform Abstract: Modular Stereoselective Synthesis of (1→2)‐C‐Glycosides Based on the sp2—sp3 Suzuki—Miyaura Reaction.
Authors: Oroszova Beata , Choutka Jan , Pohl Radek , Parkan Kamil
Published: September 2015

The key step comprises a Ni‐catalyzed cross‐coupling reaction of D‐glucal pinacol boronate with alkylbromide or alkyliodide glycoside, thus representing the first example for a challenging sp2—sp3 cross‐coupling in carbohydrate chemistry.
ChemInform Abstract: Direct Glycosylation of Unprotected and Unactivated Sugars Using Bismuth Nitrate Pentahydrate.
Authors: Polanki Innaiah K. , Kurma Siva H. , Bhattacharya Asish K.
Published: September 2015

Bismuth nitrate pentahydrate acts as an effective catalyst for the glycosylation of unactivated sugars (examples for the reaction of 5 sugars with 9 alcohols are given).
ChemInform Abstract: Synthesis and Study of N‐Acetyl D‐Glucosamine Triazole Derivatives as Effective Low Molecular Weight Gelators.
Authors: Mangunuru Hari P. R. , Yerabolu Jayasudhan Reddy , Wang Guijun
Published: September 2015

1,3‐Dipolar cycloaddition of azide (I) with alkynes provides the title triazoles (III), of which products (IIIa,b,e) are able to function as organo gelators for various solvents.
ChemInform Abstract: Armochaetoglobins K—R, anti‐HIV Pyrrole‐Based Cytochalasans from Chaetomium globosum TW1‐1.
Authors: Xue Yongbo , et al.
Published: September 2015

The anti‐HIV activities of all the isolated compounds are investigated in vitro.
ChemInform Abstract: Geranylated Flavanones from Paulownia coreana and Their Inhibitory Effects on Nitric Oxide Production.
Authors: Jin Qinghao , Lee Chul , Lee Jin Woo , Lee Dongho , Kim Youngsoo , Hong Jin Tae , Kim Jin Sook , Kim Joo‐Hwan , Lee Mi Kyeong , Hwang Bang Yeon
Published: September 2015

A new geranylated flavone (I) is isolated along with ten known compounds.
ChemInform Abstract: Structure, Absolute Configuration, and Conformational Study of Resorcylic Acid Derivatives and Related Congeners from the Fungus Penicillium brocae.
Authors: Zhang Peng , Meng Ling‐Hong , Mandi Attila , Li Xiao‐Ming , Kurtan Tibor , Wang Bin‐Gui
Published: September 2015

One new resorcylic acid derivative (IV), and five new loop‐opened resorcylic acid‐related congeners, including brocapyrone A (III), and brocaketones A‐D (structure examples (I) and (II)) are isolated together with three known compounds.
ChemInform Abstract: Mexicanolide Limonoids with in vitro Neuroprotective Activities from Seeds of Khaya senegalensis.
Authors: Li Hui , Li Yi , Wang Xiao‐Bing , Pang Tao , Zhang Lu‐Yong , Luo Jun , Kong Ling‐Yi
Published: September 2015

Fourteen new mexicanolide‐type limonoids, khasenegasins A‐N (structure example (I)) are isolated together with three known compounds i.e.
ChemInform Abstract: Synthesis of Manganese Dioxide/Iron Oxide/Graphene Oxide Magnetic Nanocomposites for Hexavalent Chromium Removal.
Authors: Liu Yan , Luo Chao , Cui Guijia , Yan Shiqiang
Published: September 2015

MnO2/Fe3O4/graphene oxide (GO) and MnO2/Fe3O4/graphene nanocomposites are prepared by a two‐step reaction involving solvothermal reaction of an ultrasonicated dispersion of graphene oxide and Fe(acac)3 in ethylene glycol with and without the addition of N2H4 hydrate (autoclave, 180 °C, 16 h) followed by MnO2 coating in an KMnO4 aqueous solution (circulator, 80 °C, 3 h, pH 5 and pH 2).
ChemInform Abstract: [CuO]+ and [CuOH]2+ Complexes: Intermediates in Oxidation Catalysis?
Authors: Gagnon Nicole , Tolman William B.
Published: September 2015

Review: 55 refs.
ChemInform Abstract: Mo‐V‐Phosphoric Heteropoly Acids and Their Salts: Aqueous Solution Preparation — Challenges and Perspectives
Authors: Odyakov Victor F. , Zhizhina Elena G. , Rodikova Yulia A. , Gogin Leonid L.
Published: September 2015

Review: [156 refs.
ChemInform Abstract: Recent Developments in the Preparation and Chemistry of Metallacycles and Metallacages via Coordination
Authors: Cook Timothy R. , Stang Peter J.
Published: September 2015

Review: 367 refs.
ChemInform Abstract: Gold Catenanes
Authors: Puddephatt R. J.
Published: September 2015

Review: chemistry of gold catenanes; 76 refs.
ChemInform Abstract: Constructing Coordination Nanocages: The Metalloligand Approach
Authors: Li Li , Fanna Daniel J. , Shepherd Nicholas D. , Lindoy Leonard F. , Li Feng
Published: September 2015

Review: 31 refs.
ChemInform Abstract: Novel Platinum(II)‐Complexes Incorporating Optically Active P‐Heterocycles as the Ligands
Authors: Bagi Peter , Kovacs Tamara , Kollar Laszlo , Fogassy Elemer , Keglevich Gyorgy
Published: September 2015

Review: 11 refs.
ChemInform Abstract: Carbastannatranes: A Powerful Coupling Mediators in Stille Coupling
Authors: Srivastav Neha , Singh Raghubir , Kaur Varinder
Published: September 2015

Review: 96 refs.
ChemInform Abstract: Metal Catalyzed Allylic Alkylation: Its Development in the Trost Laboratories
Authors: Trost Barry M.
Published: September 2015

Review: [138 refs.
ChemInform Abstract: Ethynyl Benziodoxolone (EBX): Installing Alkynes the Reversed Way
Authors: Kaschel Johannes , Werz Daniel B.
Published: September 2015

Review: use of the hypervalent iodine reagent EBX (ethynyl benziodoxolone) for the electrophilic introduction of alkynes; 17 refs.
ChemInform Abstract: Recent Advances in Iodine Monochloride Mediated Electrophilic Cyclizations
Authors: Singh Sarbjit , Chimni Swapandeep Singh
Published: September 2015

Review: [86 refs.
ChemInform Abstract: Catalysis Inside Dendrimers
Authors: Astruc Didier , Wang Dong , Deraedt Christophe , Liang Liyuang , Ciganda Roberto , Ruiz Jaime
Published: September 2015

Review: [131 refs.
ChemInform Abstract: The Eschenmoser Sulfide Contraction Method and Its Application in the Synthesis of Natural Products
Authors: Hussaini Syed Raziullah , Chamala Raghu Ram , Wang Zhiguo
Published: September 2015

Review: [173 refs.
ChemInform Abstract: Recent Developments in Synthetic Carbohydrate‐Based Diagnostics, Vaccines, and Therapeutics
Authors: Fernandez‐Tejada Alberto , Canada F. Javier , Jimenez‐Barbero Jesus
Published: September 2015

Review: [107 refs.
ChemInform Abstract: Decarboxylative Functionalization of Cinnamic Acids
Authors: Borah Arun Jyoti , Yan Guobing
Published: September 2015

Review: [88 refs.
ChemInform Abstract: Enantioselective Cooperative Catalysis
Authors: Inamdar Suleman M. , Shinde Valmik S. , Patil Nitin T.
Published: September 2015

Review: [102 refs.
ChemInform Abstract: Iodine‐Catalyzed Oxidative Coupling Reactions Utilizing C—H and X—H as Nucleophiles
Authors: Liu Dong , Lei Aiwen
Published: September 2015

Review: [77 refs.
ChemInform Abstract: Gold Catalysis for Hydrogenation Reactions
Authors: Corma Avelino , Sabater Maria J.
Published: September 2015

Review: 220 refs.
ChemInform Abstract: Preparation and Synthetic Value of π‐Bond‐Rich Branched Hydrocarbons
Authors: Sherburn Michael S.
Published: September 2015

Review: 46 refs.
ChemInform Abstract: Molecular Metal Phosphonates
Authors: Goura Joydeb , Chandrasekhar Vadapalli
Published: September 2015

Review: synthesis, structure and applications; 363 refs.
ChemInform Abstract: Sustainable Solid Catalysts for Cyclic Carbonate Synthesis from CO2 and Epoxide
Authors: Lang Xian‐Dong , Liu Xiao‐Fang , He Liang‐Nian
Published: September 2015

Review: 127 refs.
ChemInform Abstract: Chemistry and Biological Activity of Pyridotriazolopyrimidines
Authors: Farghaly Thoraya A. , Dawood Kamal M. , Shaaban Mohamed R.
Published: September 2015

Review: 66 refs.
ChemInform Abstract: Synthetic Routes to Some Azolyl‐Triazoles
Authors: Abdel‐Wahab Bakr Fathy
Published: September 2015

Review: 46 refs.
ChemInform Abstract: Pd‐Catalyzed Reactions of Unactivated Csp3‐I Bonds
Authors: Liu Hui , Jiang Xuefeng
Published: September 2015

Review: 72 refs.
ChemInform Abstract: A Review on the Synthesis and Anti‐Cancer Activity of 2‐Substituted Quinolines
Authors: Gopaul Kaalin , Shintre Suhas A. , Koorbanally Neil A.
Published: September 2015

Review: 50 refs.
ChemInform Abstract: Synthesis of 5,6‐ and 6,6‐Spirocyclic Compounds
Authors: Brimble Margaret A. , Stubbing Louise A.
Published: September 2015

Review: 204 refs.
ChemInform Abstract: Synthetic Methods of α‐Pyridinyl and α‐Bipyridinyl Alcohols and α,α′‐Pyridine and α,α′‐Bipyridine Diols
Authors: Tolea Tt , Jordaana J. H. L. , Vosloo H. C. M.
Published: September 2015

Review: 263 refs.
ChemInform Abstract: Beyond Pentacenes: Synthesis and Properties of Higher Acenes
Authors: Toenshoff Christina , Bettinger Holger F.
Published: September 2015

Review: 863 refs.].
ChemInform Abstract: Silica‐Supported Chiral Catalysts for Asymmetric Transfer Hydrogenation
Authors: Cheng Tanyu , Zhao Qiankun , Zhang Dacheng , Liu Guohua
Published: September 2015

Review: 50 refs.
ChemInform Abstract: Microwave‐Assisted Synthesis of 2‐Pyridone and 2‐Pyridone‐Based Compounds
Authors: Mijin Dusan Z. , Markovic Jelena M. , Brkovic Danijela V. , Marinkovic Aleksandar D.
Published: September 2015

Review: 85 refs.
ChemInform Abstract: Heck—Matsuda Reaction Catalyzed by Heterogeneous Palladium Catalysts
Authors: Oger Nicolas , Le Grognec Erwan , Felpin Francois‐Xavier
Published: September 2015

Review: 89 refs.
ChemInform Abstract: Overview of Polycyclic Aromatic Compounds (PAC)
Authors: Achten Christine , Andersson Jan T.
Published: September 2015

Review: 24 refs.
ChemInform Abstract: Electrochromic and Unique Chiroptical Properties of Helically Deformed Tetraarylquinodimethanes Generated from Less‐Hindered Dicationic Precursors Upon Reduction
Authors: Suzuki Takanori , Sakano Yuto , Iwai Tomohiro , Iwashita Shinichi , Miura Youhei , Katoono Ryo , Kawai Hidetoshi , Fujiwara Kenshu , Tsuji Yasushi , Fukushima Takanori
Published: September 2015

Review: 23 refs.
ChemInform Abstract: Dissociation Energies of N—H Bonds in Aromatic Amines
Authors: Denisov E. T. , Denisova T. G.
Published: September 2015

Review: 42 refs.
ChemInform Abstract: Structural Variations in Aromatic 2π‐Electron Three‐Membered Rings of the Main Group Elements
Authors: Mallick Dibyendu , Jemmis Eluvathingal D.
Published: September 2015

Review: 29 refs.
ChemInform Abstract: Photobiocatalysis: The Power of Combining Photocatalysis and Enzymes
Authors: Macia‐Agullo Juan Antonio , Corma Avelino , Garcia Hermenegildo
Published: September 2015

Review: 98 refs.
ChemInform Abstract: Low‐Temperature Solid‐Oxide Fuel Cells
Authors: Wachsman Eric , Ishihara Tatsumi , Kilner John
Published: September 2015

Review: 50 refs.
ChemInform Abstract: Green Chemistry for Nanoparticle Synthesis
Authors: Duan Haohong , Wang Dingsheng , Li Yadong
Published: September 2015

Review: 50 refs.
ChemInform Abstract: Ruthenium and Osmium Complexes that Bear Functional Azolate Chelates for Dye‐Sensitized Solar Cells
Authors: Chi Yun , Wu Kuan‐Lin , Wei Tzu‐Chien
Published: September 2015

Review: [preparation, molecular design, structural relationship, and performance characteristics; 85 refs.
ChemInform Abstract: Recent Progress in Luminescent Liquid Crystal Materials: Design, Properties and Application for Linearly Polarized Emission
Authors: Wang Yafei , Shi Junwei , Chen Jianhua , Zhu Weiguo , Baranoff Etienne
Published: September 2015

Review: 121 refs.
ChemInform Abstract: In situ Synthesis of Amide‐imidate‐imidazolate Ligand and Formation of Metal‐Organic Frameworks: Application for Gas Storage
Authors: Mondal Suvendu Sekhar , Thomas Arne , Holdt Hans‐Juergen
Published: September 2015

Review: 66 refs.
ChemInform Abstract: Conventional Methods and Emerging Wastewater Polishing Technologies for Palm Oil Mill Effluent Treatment: A Review
Authors: Liew Wai Loan , Kassim Mohd. Azraai , Muda Khalida , Loh Soh Kheang , Affam Augustine Chioma
Published: September 2015

Review: 82 refs.
ChemInform Abstract: Four Decades of the Chemistry of Planar Hypercoordinate Compounds
Authors: Yang Li‐Ming , Ganz Eric , Chen Zhongfang , Wang Zhi‐Xiang , von Rague Schleyer Paul
Published: September 2015

Review: [183 refs.
ChemInform Abstract: The Claisen Rearrangement. Part 1. Mechanisms and Transition States, Revisited with Quantum Mechanical Calculations and Ultrashort Pulse Spectroscopy
Authors: Zelentsov Sergei , Hessel Volker , Shahbazali Elnaz , Noel Timothy
Published: September 2015

Review: 62 refs.
ChemInform Abstract: Revisiting Carbon‐Detected NMR Experiments in Light of Technological Advances in Modern Instrumentation
Authors: Ridge Clark D. , Mazzola Eugene P.
Published: September 2015

Review: 10 refs.
Suspicious cytologic diagnostic category in endoscopic ultrasound‐guided FNA of the pancreas: Follow‐up and outcomes
Authors: Alston Evan A. , Bae Sejong , Eltoum Isam A.
Published: September 2015

BACKGROUND

The objective of the current study was to assess how the suspicious category is followed up in a large endoscopic ultrasound‐guided fine‐needle aspiration (EUS‐FNA) service, its outcomes, and the predictors that are likely to be associated with the subsequent diagnosis of a neoplastic process.

METHODS

For pancreatic EUS‐FNA samples with the suspicious category diagnosis, the authors reviewed the electronic medical record for the method of follow‐up and the risks associated with pancreatic malignancy. Logistic regression analysis was used to determine the risk factors that were likely to be associated with the diagnosis of a neoplastic lesion after a cytologic diagnosis of “suspicious.”

RESULTS

Of a total of 3832 EUS‐FNA cases, 116 were diagnosed with suspicious cytology. A total of 90 of 98 neoplasms (92%) were identified, including 72 carcinomas (73%). Similar rates of neoplasia were detected after repeat FNA (34 of 37 neoplasms [92%]) and subsequent biopsy/surgical resection (44 of 46 neoplasms [96%]), but significantly fewer neoplasms were detected among patients with clinical follow‐up (18 of 23 neoplasms [78%]). On multivariate analysis of the potential predictive variables listed above, the presence of a mass was found to be significantly associated with a higher rate of diagnosis of a neoplasm, whereas weight loss was significantly associated with a diagnosis of carcinoma.

CONCLUSIONS

The diagnostic category of “suspicious” is associated with a high risk of benign and malignant neoplasms, regardless of the method of follow‐up. The presence of a mass and weight loss are significant predictors of a subsequent diagnosis of a neoplasm after suspicious cytology. In patients with suspicious cytology and these findings, surgery is recommended for resectable masses and repeat FNA for unresectable masses. Cancer (Cancer Cytopathol) 2016;124:53–57. © 2015 American Cancer Society.
BRAF testing and thyroid FNA
Authors: Pusztaszeri Marc P. , Krane Jeffrey F. , Faquin William C.
Published: September 2015

The BRAF V600E mutation represents the single most specific marker of malignancy in thyroid nodules, and there are selected scenarios in which BRAF testing alone can be useful.
Synthesis of a Sulfonated Two‐Dimensional Covalent Organic Framework as an Efficient Solid Acid Catalyst for Biobased Chemical Conversion
Authors: Peng Yongwu , Hu Zhigang , Gao Yongjun , Yuan Daqiang , Kang Zixi , Qian Yuhong , Yan Ning , Zhao Dan
Published: September 2015

Because of limited framework stability tolerance, de novo synthesis of sulfonated covalent organic frameworks (COFs) remains challenging and unexplored. Herein, a sulfonated two‐dimensional crystalline COF, termed TFP‐DABA, was synthesized directly from 1,3,5‐triformylphloroglucinol and 2,5‐diaminobenzenesulfonic acid through a previously reported Schiff base condensation reaction, followed by irreversible enol‐to‐keto tautomerization, which strengthened its structural stability. TFP‐DABA is a highly efficient solid acid catalyst for fructose conversion with remarkable yields (97 % for 5‐hydroxymethylfurfural and 65 % for 2,5‐diformylfuran), good chemoselectivity, and good recyclability. The present study sheds light on the de novo synthesis of sulfonated COFs as novel solid acid catalysts for biobased chemical conversion.
Angiopoietin‐2 in acute myocardial infarction complicated by cardiogenic shock—a biomarker substudy of the IABP‐SHOCK II‐Trial
Authors: Pöss Janine , Fuernau Georg , Denks Daniel , Desch Steffen , Eitel Ingo , de Waha Suzanne , Link Andreas , Schuler Gerhard , Adams Volker , Böhm Michael , Thiele Holger
Published: September 2015

Aims

Angiopoietin‐2 (Ang‐2) is a mediator of capillary leakage, and increased Ang‐2 levels were associated with poor in‐hospital outcome in a pilot study in cardiogenic shock (CS). In this larger study, we followed this hypothesis and aimed at assessing the predictive role of Ang‐2 on short‐ and long‐term mortality, investigating the effect of intra‐aortic balloon pump (IABP) treatment on Ang‐2 levels, and identifying clinical and procedural predictors of increased Ang‐2.

Methods and results

In the IABP‐SHOCK II‐trial, 600 patients with CS complicating acute myocardial infarction were assigned to therapy with or without IABP. This substudy included 189 randomized patients with serial blood sampling performed at days 1, 2, and 3. No significant differences in Ang‐2 levels were found between patients with or without IABP. The Ang‐2 levels above the median at day 1 were associated with 30‐day [hazard ratio (HR) 1.98, 95% confidence interval (CI) 1.26–3.10, P = 0.002) and 1‐year mortality (HR 2.21, 95% CI 1.49–3.27, P < 0.001). Stratification of patients according to Ang‐2 levels at day 3 increased these associations (30 days HR 5.15, 95% CI 2.80–9.45, P < 0.001; 1 year HR 5.24, 95% CI 3.19–8.58, P < 0.001). The Ang‐2 concentrations were independent predictors for mortality in multivariate analysis (30 days HR 4.82, 95% CI 1.52–15.23, P = 0.007; 1 year HR 2.01, 95%CI 1.24–3.24, P = 0.005). Predictors of increased Ang‐2 levels at day 3 were baseline Ang‐2, development of acute kidney injury, bleeding events or transfusion, and impaired reperfusion.

Conclusion

In CS, high levels of Ang‐2 are independently associated with poor short‐ and long‐term outcome and associated with the reperfusion success as well as complications.

Clinical Trial Registration

URL: www.clinicaltrials.gov; unique identifier: NCT00491036