bluuebunny/crossref_metadata_2025 huggingface dataset:
Genetic and non-genetic determinants of thymic epithelial cell number and function
Authors: Nagakubo Daisuke , Krauth Brigitte , Boehm Thomas
Published: August 2017

The thymus is the site of T cell development in vertebrates. In general, the output of T cells is determined by the number of thymic epithelial cells (TECs) and their relative thymopoietic activity. Here, we show that the thymopoietic activity of TECs differs dramatically between individual mouse strains. Moreover, in males of some strains, TECs perform better on a per cell basis than their counterparts in females; in other strains, this situation is reversed. Genetic crosses indicate that TEC numbers and thymopoietic capacity are independently controlled. Long-term analysis of functional parameters of TECs after castration provides evidence that the number of Foxn1-expressing TECs directly correlates with thymopoietic activity. Our study highlights potential complications that can arise when comparing parameters of TEC biology across different genetic backgrounds; these could affect the interpretation of the outcomes of interventions aimed at modulating thymic activity in genetically diverse populations, such as humans.
GDP-D-mannose epimerase regulates male gametophyte development, plant growth and leaf senescence in Arabidopsis
Authors: Qi Tiancong , Liu Zhipeng , Fan Meng , Chen Yan , Tian Haixia , Wu Dewei , Gao Hua , Ren Chunmei , Song Susheng , Xie Daoxin
Published: August 2017

Plant GDP-D-mannose epimerase (GME) converts GDP-D-mannose to GDP-L-galactose, a precursor of both L-ascorbate (vitamin C) and cell wall polysaccharides. However, the genetic functions of GME in Arabidopsis are unclear. In this study, we found that mutations in Arabidopsis GME affect pollen germination, pollen tube elongation, and transmission and development of the male gametophyte through analysis of the heterozygous GME/gme plants and the homozygous gme plants. Arabidopsis gme mutants also exhibit severe growth defects and early leaf senescence. Surprisingly, the defects in male gametophyte in the gme plants are not restored by L-ascorbate, boric acid or GDP-L-galactose, though boric acid rescues the growth defects of the mutants, indicating that GME may regulate male gametophyte development independent of L-ascorbate and GDP-L-galactose. These results reveal key roles for Arabidopsis GME in reproductive development, vegetative growth and leaf senescence, and suggest that GME regulates plant growth and controls male gametophyte development in different manners.
A novel quantitative PCR mediated by high-fidelity DNA polymerase
Authors: Zhang Mengling , Liu Kyle , Hu Yihong , Lin Yi , Li Yang , Zhong Ping , Jin Xia , Zhu Xiaoli , Zhang Chiyu
Published: August 2017

The biggest challenge for accurate diagnosis of viral infectious disease is the high genetic variability of involved viruses, which affects amplification efficiency and results in low sensitivity and narrow spectrum. Here, we developed a new simple qPCR mediated by high-fidelity (HF) DNA polymerase. The new method utilizes an HFman probe and one primer. Fluorescent signal was generated from the 3′–5′ hydrolysis of HFman probe by HF DNA polymerase before elongation initiation. Mismatches between probe/primer and template have less influence on the amplification efficiency of the new method. The new qPCR exhibited higher sensitivity and better adaptability to sequence variable templates than the conventional TaqMan probe based-qPCR in quantification of HIV-1 viral load. Further comparison with COBAS TaqMan HIV-1 Test (v2.0) showed a good correlation coefficient (R2 = 0.79) between both methods in quantification of HIV-1 viral load among 21 clinical samples. The characteristics of tolerance to variable templates and one probe-one primer system imply that the probe/primer design for the new method will be easier and more flexible than the conventional method for highly heterogeneous viruses. Therefore, the HF DNA polymerase-mediated qPCR method is a simple, sensitive and promising approach for the development of diagnostics for viral infectious diseases.
Erythropoietin enhances Kupffer cell number and activity in the challenged liver
Authors: Gilboa Dafna , Haim-Ohana Yasmin , Deshet-Unger Naamit , Ben-Califa Nathalie , Hiram-Bab Sahar , Reuveni Debby , Zigmond Ehud , Gassmann Max , Gabet Yankel , Varol Chen , Neumann Drorit
Published: August 2017

Erythropoietin (EPO) is the main hormone driving mammalian erythropoiesis, with activity mediated via the surface receptor, EPO-R, on erythroid progenitor cells. Recombinant human EPO is currently used clinically for the treatment of anemia in patients with end-stage renal disease, and in certain cancer patients suffering from anemia induced either by the tumor itself or by chemotherapy. EPO-R expression is also detected in non-erythroid cells, including macrophages present in the peritoneum, spleen, and bone marrow (BM). Here we demonstrate that Kupffer cells (KCs) - the liver-resident macrophages - are EPO targets. We show that, in vitro, EPO initiated intracellular signalling and enhanced phagocytosis in a rat KC line (RKC-2) and in sorted KCs. Moreover, continuous EPO administration in mice, resulted in an increased number of KCs, up-regulation of liver EPO-R expression and ﻿﻿﻿elevated﻿ production of the monocyte chemoattractant CCL2, with corresponding egress of Ly6Chi monocytes from the BM. In a model of acute acetaminophen-induced liver injury, EPO administration increased the recruitment of Ly6Chi monocytes and neutrophils to the liver. Taken together, our results reveal a new role for EPO in stimulating KC proliferation and phagocytosis, and in recruiting Ly6Chi monocytes in response to liver injury.
Monolithic integration of AlGaInP-based red and InGaN-based green LEDs via adhesive bonding for multicolor emission
Authors: Kang Chang-Mo , Kang Seok-Jin , Mun Seung-Hyun , Choi Soo-Young , Min Jung-Hong , Kim Sanghyeon , Shim Jae-Phil , Lee Dong-Seon
Published: August 2017

In general, to realize full color, inorganic light-emitting diodes (LEDs) are diced from respective red-green-blue (RGB) wafers consisting of inorganic crystalline semiconductors. Although this conventional method can realize full color, it is limited when applied to microdisplays requiring high resolution. Designing a structure emitting various colors by integrating both AlGaInP-based and InGaN-based LEDs onto one substrate could be a solution to achieve full color with high resolution. Herein, we introduce adhesive bonding and a chemical wet etching process to monolithically integrate two materials with different bandgap energies for green and red light emission. We successfully transferred AlGaInP-based red LED film onto InGaN-based green LEDs without any cracks or void areas and then separated the green and red subpixel LEDs in a lateral direction; the dual color LEDs integrated by the bonding technique were tunable from the green to red color regions (530–630 nm) as intended. In addition, we studied vertically stacked subpixel LEDs by deeply analyzing their light absorption and the interaction between the top and bottom pixels to achieve ultra-high resolution.
RefEx, a reference gene expression dataset as a web tool for the functional analysis of genes
Authors: Ono Hiromasa , Ogasawara Osamu , Okubo Kosaku , Bono Hidemasa
Published: August 2017

Gene expression data are exponentially accumulating; thus, the functional annotation of such sequence data from metadata is urgently required. However, life scientists have difficulty utilizing the available data due to its sheer magnitude and complicated access. We have developed a web tool for browsing reference gene expression pattern of mammalian tissues and cell lines measured using different methods, which should facilitate the reuse of the precious data archived in several public databases. The web tool is called Reference Expression dataset (RefEx), and RefEx allows users to search by the gene name, various types of IDs, chromosomal regions in genetic maps, gene family based on InterPro, gene expression patterns, or biological categories based on Gene Ontology. RefEx also provides information about genes with tissue-specific expression, and the relative gene expression values are shown as choropleth maps on 3D human body images from BodyParts3D. Combined with the newly incorporated Functional Annotation of Mammals (FANTOM) dataset, RefEx provides insight regarding the functional interpretation of unfamiliar genes. RefEx is publicly available at http://refex.dbcls.jp/.
Correction: Corrigendum: Magnetic Tunnel Junction Mimics Stochastic Cortical Spiking Neurons
Authors: Sengupta Abhronil , Panda Priyadarshini , Wijesinghe Parami , Kim Yusung , Roy Kaushik
Published: August 2017

Scientific Reports 6: Article number: 30039; published online: 21 July 2016; updated: 29 August 2017. This Article contains an error in Equation 2. should read:
Decreased AGO2 and DCR1 in PBMCs from War Veterans with PTSD leads to diminished miRNA resulting in elevated inflammation
Authors: Bam M , Yang X , Zumbrun E E , Ginsberg J P , Leyden Q , Zhang J , Nagarkatti P S , Nagarkatti M
Published: August 2017

Chronic inflammation is a characteristic of post-traumatic stress disorder (PTSD). The initiation of inflammation and molecules involved are not yet clearly understood. Here, we provide compelling evidence that the inflammation seen in PTSD may result from the dysregulated miRNA processing pathway. Using microarray analysis with a discovery group of peripheral blood mononuclear cell (PBMC) samples from War Veterans with PTSD, we found 183 significantly downregulated miRNAs, several of which target numerous genes categorized to be pro-inflammatory in nature. This observation was further confirmed in a replicate group by including more samples. Furthermore, employing RNA-sequencing, quantitative real time PCR (qRT-PCR) and in vitro experiments, we found that Argonaute 2 (AGO2) and Dicer1 (DCR1) were downregulated in PTSD and provided convincing evidence that their downregulation affects mature miRNA generation. In addition, we noted that STAT3 transcript was reduced in PTSD and this was possibly responsible for reduced AGO2 and DCR1, which in turn affected miRNA synthesis. Furthermore, we observed that activation of CD4+ T cells or monocytes led to reduced mature miRNA availability. Finally, the inflammation seen in PTSD was associated with downregulated miRNA profile. Altogether, the current study demonstrates that the chronic inflammation seen in PTSD may be a result of dysregulated miRNA biogenesis pathway due to diminished expression of the key molecules like AGO2, DCR1 and STAT3.
Neural stem cell proliferation and differentiation in the conductive PEDOT-HA/Cs/Gel scaffold for neural tissue engineering
Authors: Wang Shuping , Guan Shui , Xu Jianqiang , Li Wenfang , Ge Dan , Sun Changkai , Liu Tianqing , Ma Xuehu
Published: August 2017

Engineering scaffolds with excellent electro-activity is increasingly important in tissue engineering and regenerative medicine.
Reactivity of a stable copper–dioxygen complex
Authors: Iovan Diana A. , Wrobel Alexandra T. , McClelland Arthur A. , Scharf Austin B. , Edouard Guy A. , Betley Theodore A.
Published: August 2017

A stable Cu–dioxygen adduct is observed that effects both H-atom abstraction and O-atom transfer chemistry.
Calculation and experimental measurement of paramagnetic NMR parameters of phenolic oximate Cu(ii) complexes
Authors: Dawson Daniel M. , Ke Zhipeng , Mack Frederick M. , Doyle Rachel A. , Bignami Giulia P. M. , Smellie Iain A. , Bühl Michael , Ashbrook Sharon E.
Published: August 2017

Unusual 1H and 13C NMR shifts for paramagnetic bisoximato copper(ii) complexes are understood by combining DFT calculations and multidimensional experiments.
Origins of the enhanced affinity of RNA–protein interactions triggered by RNA phosphorodithioate backbone modification
Authors: Yang Xianbin , Dinuka Abeydeera N. , Liu Feng-Wu , Egli Martin
Published: August 2017

A single phosphorodithioate in place of a phosphate in a 19mer hairpin-RNA regio-specifically boosts its affinity for MS2 phage coat protein.
Escaping the trap of complication and complexity in multiscale microkinetic modelling of heterogeneous catalytic processes
Authors: Maestri Matteo
Published: August 2017

The hierarchical multiscale approach allows for escaping the trap of complication and complexity in multiscale microkinetic modelling of heterogeneous catalytic processes.
Visible light photocatalytic decarboxylative monofluoroalkenylation of α-amino acids with gem-difluoroalkenes
Authors: Li Jingjing , Lefebvre Quentin , Yang Haijun , Zhao Yufen , Fu Hua
Published: August 2017

A novel, efficient and general visible-light photocatalytic decarboxylative monofluoroalkenylation of N-protected α-amino acids with gem-difluoroalkenes is reported, affording the corresponding α-amino monofluoroalkenes.
Halogen free 1,2,3- and 1,2,4-triazolide based ionic liquids: synthesis and properties
Authors: Savateev Aleksandr , Liedel Clemens , Tröger-Müller Steffen , de León Alberto S. , Antonietti Markus , Dontsova Dariya
Published: August 2017

Synthesis and characterization of novel triazole based halogen free ionic liquids.
Direct diversification of unmasked quinazolin-4(3H)-ones through orthogonal reactivity modulation
Authors: Lee Jae Bin , Kang Mi Eun , Kim Joohee , Lee Chang Young , Kee Jung-Min , Myung Kyungjae , Park Jang-Ung , Hong Sung You
Published: August 2017

An orthogonal reactivity modulation strategy affords diverse synthetic analogues from unmasked quinazolin-4(3H)-ones.
Scavenging activity of Magnéli phases as a function of Ti4+/Ti3+ratios
Authors: Canillas M. , Chinarro E. , Pêgo A. P. , Moreno B.
Published: August 2017

TiO2is able to scavenge reactive oxygen and nitrogen species (ROS and RNS) in the absence of light.
An anionic Na(i)–organic framework platform: separation of organic dyes and post-modification for highly sensitive detection of picric acid
Authors: Chen Di-Ming , Tian Jia-Yue , Wang Zhuo-Wei , Liu Chun-Sen , Chen Min , Du Miao
Published: August 2017

A unique nanoporous Na(i)-MOF with excellent dye separation performance is presented and the dye@MOF composite could be applied as a luminescent sensor for picric acid detection.
Synthesis and characterization of Lewis base stabilized mono- and di-organo aluminum radicals
Authors: Kundu Subrata , Sinhababu Soumen , Dutta Sayan , Mondal Totan , Koley Debasis , Dittrich Birger , Schwederski Brigitte , Kaim Wolfgang , Stückl A. Claudia , Roesky Herbert W.
Published: August 2017

Synthesis, structure, EPR and theoretical calculations of cyclic (alkyl)(amino)carbene stabilized mononuclear neutral radicals of aluminum containing mono- and di-organo groups.
Effect of protic additives in Cu-catalysed asymmetric Diels–Alder cycloadditions of doubly activated dienophiles: towards the synthesis of magellanine-type Lycopodium alkaloids
Authors: Lindsay Vincent N. G. , Murphy Rebecca A. , Sarpong Richmond
Published: August 2017

The effect of protic additives in an enantioselective Diels–Alder reaction is reported and applied towards the synthesis of magellaninone.
Structure identification of Ti(iv) clusters in low-temperature TiO2 crystallization: creating high-surface area brush-shaped rutile TiO2
Authors: Manseki Kazuhiro , Saka Kazuki , Matsui Masaki , Vafaei Saeid , Sugiura Takashi
Published: August 2017

We demonstrate for the first time a controlled reaction of Cl-coordinating Ti(iv) clusters in low-temperature hydrolysis (27 °C) to create large-surface area rutile TiO2 crystals.
Fabrication of metalosomes (metal containing cationic liposomes) using single chain surfactants as a precursor via formation of inorganic organic hybrids
Authors: Garg Preeti , Kaur Gurpreet , Chaudhary Ganga Ram , Gawali Santosh L. , Hassan P. A.
Published: August 2017

This work reveals a methodology to modify a single chain surfactant to fabricate a liposome-like assembly by controlling the stoichiometry by virtue of a metallic counter ion. It is a noteworthy advancement in the area of self-assembled molecular structures.
Controlling the magnetic and optical responses of a MoS2 monolayer by lanthanide substitutional doping: a first-principles study
Authors: Ouma Cecil N. M. , Singh Sobhit , Obodo Kingsley O. , Amolo George O. , Romero Aldo H.
Published: August 2017

The absorption spectrum and TDOS of lanthanide doped MoS2 for the E-field parallel and perpendicular to the xy-plane.
Phase separation and physico-chemical processes at microscopic and macroscopic levels in MWCNT laden polymer blends using a unique droplet based architecture
Authors: Pathak Binita , Kar Goutam Prasanna , Bose Suryasarathi , Basu Saptarshi
Published: August 2017

We propose a unique contact-free droplet based architecture to alter the phase separation behavior in binary polymer solution (PS/PVME in toluene) by tuning the external heating rate and concentration of added MWCNT particles.
Effects of a phosphonate anchoring group on the excited state electron transfer rates from a terthiophene chromophore to a ZnO nanocrystal
Authors: Oehrlein Amanda N. , Sanchez-Diaz Antonio , Goff Philip C. , Ziegler Gretchen M. , Pappenfus Ted M. , Mann Kent R. , Blank David A. , Gladfelter Wayne L.
Published: August 2017

Relative to carboxyl-anchored chromophores, phosphonate-anchored dyes are bound more strongly but slow the excited state electron transfer to ZnO nanocrystals.
Surface modification induced enhanced CO2 sorption in cucurbit[6]uril, an organic porous material
Authors: Mohan Midhun , Suzuki T. , Nair Akhil K. , Pillai Saju , Warrier K. G. K. , Hareesh U. S. , Nair Balagopal N. , Gale J. D.
Published: August 2017

Theoretical and experimental studies on CO2 sorption of the organic macrocycle cucurbit[6]uril (CB[6]).
How many surface atoms in Co3O4 take part in oxygen evolution? Isotope labeling together with differential electrochemical mass spectrometry
Authors: Amin Hatem M. A. , Baltruschat Helmut
Published: August 2017

The outermost oxygen atoms of Co3O4 particles participate in oxygen evolution via a surface oxygen exchange mechanism, as suggested by isotope labeling together with DEMS.
Interfacial engineering of hole transport layers with metal and dielectric nanoparticles for efficient perovskite solar cells
Authors: Wang Dian , Chan Kah H. , Elumalai Naveen Kumar , Mahmud Md. Arafat , Upama Mushfika B. , Uddin Ashraf , Pillai Supriya
Published: August 2017

In this work, we have demonstrated the incorporation of metal (Ag NPs) and dielectric nanoparticles (SiO2 NPs) into the hole transporting layers of inverted PSCs using facile deposition methods.
Non-noble metal plasmonic photocatalysis in semimetal bismuth films for photocatalytic NO oxidation
Authors: Zhou Ying , Li Wei , Zhang Qian , Yan Shuai , Cao Yuehan , Dong Fan , Wang Fang
Published: August 2017

Field enhancement and location of plasmonic resonance peaks are strongly correlated with the size of Bi particles. The low energy barrier for the conversion of NO to NO2 and low NO2 desorption energy over Bi particles indicate that Bi films are very active for photocatalytic oxidation of NO and possess good stability.
Real-time fluorescence quenching-based detection of nitro-containing explosive vapours: what are the key processes?
Authors: Shaw P. E. , Burn P. L.
Published: August 2017

We present a holistic perspective on real-time sensing via fluorescence quenching and identify the key processes behind the response.
First principles study of the Mn-doping effect on the physical and chemical properties of mullite-family Al2SiO5
Authors: Wang Qingbo , Liang Chaoping , Zheng Yongping , Ashburn Nickolas , Oh Young Jun , Kong Fantai , Zhang Chenxi , Nie Yifan , Sun Jian , He Kaihua , Ye Yu , Chen Rong , Shan Bin , Cho Kyeongjae
Published: August 2017

Transition metal (TM) modification is a common strategy for converting an earth-abundant mineral into a cost-effective catalyst for industrial applications.
Electron–phonon scattering effect on the lattice thermal conductivity of silicon nanostructures
Authors: Fu Bo , Tang Guihua , Li Yifei
Published: August 2017

The effect of electron–phonon scattering on the nanoscale thermal transport is investigated systematically in nanowires, solid thin films and nanoporous thin films by considering the phonon–phonon, phonon–boundary and electron–phonon scattering simultaneously.
Using molecular vibrations to probe exciton delocalization in films of perylene diimides with ultrafast mid-IR spectroscopy
Authors: Kennehan Eric R. , Grieco Christopher , Brigeman Alyssa N. , Doucette Grayson S. , Rimshaw Adam , Bisgaier Kayla , Giebink Noel C. , Asbury John B.
Published: August 2017

Ultrafast vibrational spectroscopy provides a direct comparison exciton delocalization in crystalline perylenediimides that informs their use in organic electronic applications.
Spin-dependent transport properties of zigzag phosphorene nanoribbons with oxygen-saturated edges
Authors: Rahman Mavlanjan , Zhou Ke-chao , Xia Qing-lin , Nie Yao-zhuang , Guo Guang-hua
Published: August 2017

We investigate the electronic structures and electronic transport properties of zigzag phosphorene nanoribbons with oxygen-saturated edges (O-zPNRs) by using the spin-polarized density functional theory and the nonequilibrium Green's function method.
Molecular simulations of palladium catalysed hydrodeoxygenation of 2-hydroxybenzaldehyde using density functional theory
Authors: Verma Anand Mohan , Kishore Nanda
Published: August 2017

The catalytic conversion of 2-hydroxybenzaldehyde (2-HB) is carried out numerically over a Pd(111) surface using density functional theory.
Diverse gatekeepers for mesoporous silica nanoparticle based drug delivery systems
Authors: Wen Jia , Yang Kui , Liu Fengyu , Li Hongjuan , Xu Yongqian , Sun Shiguo
Published: August 2017

Progress on the design of diverse gatekeepers for mesoporous silica nanoparticle based drug delivery systems is summarized.
Facile synthesis of CdS/Bi4V2O11 photocatalysts with enhanced visible-light photocatalytic activity for degradation of organic pollutants in water
Authors: Lv Taotao , Li Di , Hong Yuanzhi , Luo Bifu , Xu Dongbo , Chen Min , Shi Weidong
Published: August 2017

The development of Z-scheme heterojunction photocatalytic systems is a promising strategy to produce hydrogen and for pollutant degradation.
Cadmium–1,4-cyclohexanedicarboxylato coordination polymers bearing different di-alkyl-2,2′-bipyridines: syntheses, crystal structures and photoluminescence studies
Authors: Rosales-Vázquez Luis D. , Sánchez-Mendieta Víctor , Dorazco-González Alejandro , Martínez-Otero Diego , García-Orozco Iván , Morales-Luckie Raúl A. , Jaramillo-Garcia Jonathan , Téllez-López Antonio
Published: August 2017

Cd(ii) polymers, in acetone, can be used as luminescent materials for detection of CH3CN.
NI(ii) phosphine and phosphide complexes supported by a PNP-pyrrole pincer ligand
Authors: Kessler Julie A. , Iluc Vlad M.
Published: August 2017

Deprotonation of cationic nickel phosphines led to isolation of the corresponding phosphide or phopshinomethyl complexes.
Fluorescent mesogenic boron difluoride complexes derived from heterocyclic benzoxazoles
Authors: Chen Ya-Wen , Lee Gene-Hsiang , Lai Chung K.
Published: August 2017

One new series of boron difluoride complexes 1 derived from heterocyclic benzoxazoles 2 was reported, and their mesomorphic and optical properties were also investigated.
Material design of high-capacity Li-rich layered-oxide electrodes: Li2MnO3 and beyond
Authors: Kim Soo , Aykol Muratahan , Hegde Vinay I. , Lu Zhi , Kirklin Scott , Croy Jason R. , Thackeray Michael M. , Wolverton Chris
Published: August 2017

Material design of new Li-rich Li2(MI,MII)O3 layered oxides for high-energy-density lithium-ion batteries via multi-faceted high-throughput density function theory calculations.
Configurable microfluidic platform for investigating therapeutic delivery from biomedical device coatings
Authors: Li Zidong , Seker Erkin
Published: August 2017

This paper reports a microfluidic platform that can be configured in two physiologically-relevant modes for investigating therapeutic delivery from biomedical device coatings.
Synthesis of europium oxide-promoted Pd catalyst by an improved impregnation method as a high performance catalyst for the ethanol oxidation reaction
Authors: Alfi N. , Rezvani A. R. , Khorasani-Motlagh M. , Noroozifar M.
Published: August 2017

Simple and new strategy for the preparation of the Pd/Eu2O3 catalyst with the lowest palladium loading using Zn/HCl reduction system.
Zn2+cross-linked sodium alginate-g-allylamine-mannose polymeric carrier of rifampicin for macrophage targeting tuberculosis nanotherapy
Authors: Praphakar Rajendran Amarnath , Munusamy Murugan A. , Alarfaj Abdullah A. , Kumar S. Suresh , Rajan Mariappan
Published: August 2017

Our aim was to evaluate the capacity of polymeric nanoparticles (PNPs) to selectively deliver an antituberculosis drug (rifampicin; RF) to alveolar macrophages.
New insights into the influence of weak and strong acids on the oxidative stability and photocatalytic activity of porphyrins
Authors: Zakavi Saeed , Hoseini Saiedeh , Mojarrad Aida G.
Published: August 2017

The effects of weak and strong acids on the photocatalytic performance of porphyrins in the aerobic photooxidation of olefins are reported.
Cellular uptake of pH/reduction responsive phosphorylcholine micelles
Authors: Cai Yuanyuan , Li Shuai , Cai Mengtan , Chen Yuanwei , Luo Xianglin
Published: August 2017

We study the relationship between the PDEA content and internalization/intracellular drug release of pH responsive phosphorylcholine micelles as drug carriers.
Recent advances in organic reactions catalyzed by graphene oxide and sulfonated graphene as heterogeneous nanocatalysts: a review
Authors: Mohammadi Ozra , Golestanzadeh Mohsen , Abdouss Majid
Published: August 2017

Over the past decade, the application of carbocatalyst systems has been preferred over that of homogeneous catalytic systems because of their advantages such as physical and thermal stability of the catalysts in successive reaction runs and reusability.
The importance of asking “how and why?” in natural product structure elucidation
Authors: Brown Patrick D. , Lawrence Andrew L.
Published: August 2017

This review highlights why careful consideration of the biosynthetic origin (the how) and the biological function (the why) of a natural product can be so useful during the determination of its structure.
The biosynthesis of cytochalasans
Authors: Skellam Elizabeth
Published: August 2017

This highlight summarises the recent advances in elucidating and engineering the biosynthesis of cytochalasan natural products.
Femtosecond laser induced robust periodic nanoripple structured mesh for highly efficient oil–water separation
Authors: Yin Kai , Chu Dongkai , Dong Xinran , Wang Cong , Duan Ji-An , He Jun
Published: August 2017

We present a simple, efficient method to fabricate superhydrophilic and underwater superoleophobic stainless steel mesh surfaces for robust oil–water separation.
The relationship between cell adhesion force activation on nano/micro-topographical surfaces and temporal dependence of cell morphology
Authors: Naganuma Tamaki
Published: August 2017

Time-dependent cell morphology changed cellular capability to enhance cell adhesion force activation on nano/micro-topographies, resulting in difference cell–material interactions.
The role of spin states in the catalytic mechanism of the intra- and extradiol cleavage of catechols by O2
Authors: Stepanović S. , Angelone D. , Gruden M. , Swart M.
Published: August 2017

Intradiolvs.extradiol selectivity of Fe(iii)-complexes explained by spin-state consistent density functionals.
Tandem radical cyclization to construct poly-brominated 2-oxindoles
Authors: Chen Fengjuan , Wang Yajun , Zhao Shijun , Jiang Wei , Huo Congde
Published: August 2017

A metal-free aerobic way to construct tribromomethylated poly-brominated 2-oxindoles from reaction of N-arylacrylamides with CBr4via a tandem radical cyclization process was discovered. The formation of the 1,1-dibromoolefin derivatives was also realized at higher temperature.
Modular total syntheses of mycolactone A/B and its [2H]-isotopologue
Authors: Saint-Auret Sarah , Abdelkafi Hajer , Le Nouen Didier , Guenin-Macé Laure , Demangel Caroline , Bisseret Philippe , Blanchard Nicolas
Published: August 2017

A new synthetic blueprint of mycolactone A/B is reported, granting access to the natural product and its [2H]-isotopologue.
Correction: Computationally guided discovery of a reactive, hydrophilic trans-5-oxocene dienophile for bioorthogonal labeling
Authors: Lambert William D. , Scinto Samuel L. , Dmitrenko Olga , Boyd Samantha J. , Magboo Ronald , Mehl Ryan A. , Chin Jason W. , Fox Joseph M. , Wallace Stephen
Published: August 2017

Correction for ‘Computationally guided discovery of a reactive, hydrophilic trans-5-oxocene dienophile for bioorthogonal labeling’ by William D. Lambert et al., Org. Biomol. Chem., 2017, 15, 6640–6644.
Correction: Dissipative particle dynamics and molecular dynamics simulations on mesoscale structure and proton conduction in a SPEEK/PVDF-g-PSSA membrane
Authors: Ma Yue , Wang Yuxiang , Deng Xuejian , Zhou Guanggang , Khalid Shah , Sun Xiaoliang , Sun Wei , Zhou Qiong , Lu Guiwu
Published: August 2017

Correction for ‘Dissipative particle dynamics and molecular dynamics simulations on mesoscale structure and proton conduction in a SPEEK/PVDF-g-PSSA membrane’ by Yue Ma et al., RSC Adv., 2017, 7, 39676–39684.
Correction: Aqueous extract of Cordyceps sinensis potentiates the antitumor effect of DDP and attenuates therapy-associated toxicity in non-small cell lung cancer via IκBα/NFκB and AKT/MMP2/MMP9 pathways
Authors: Huo Xiaowei , Liu Chenqi , Bai Xuelian , Li Wenjia , Li Jing , Hu Xuefeng , Cao Li
Published: August 2017

Correction for ‘Aqueous extract of Cordyceps sinensis potentiates the antitumor effect of DDP and attenuates therapy-associated toxicity in non-small cell lung cancer via IκBα/NFκB and AKT/MMP2/MMP9 pathways’ by Xiaowei Huo et al., RSC Adv., 2017, 7, 37743–37754.
m-C2B10H11HgCl/AgOTf-Catalyzed Reaction for Reductive Deoxygenation
Authors: Yamasaki Naoto , Kanno Marina , Sakamoto Kyohei , Kasai Yusuke , Imagawa Hiroshi , Yamamoto Hirofumi
Published: August 2017

A m-C2B10H11HgCl/AgOTf-catalyzed reaction of allyl silyl ethers with N-Boc-N′-tosylhydrazine has been developed. Under mild conditions, the resulting allyl hydrazine products were transformed into naked alkenes in good yield. Furthermore, the used m-C2B10H11HgCl could be recovered quantitatively.
Synthesis of N-Arylsulfonamides by a Copper-Catalyzed Reaction of Chloramine-T and Arylboronic Acids at Room Temperature
Authors: Ouyang Banlai , Qiu Guanyinsheng , Liu Deming , Xia Kejian , Zheng Yanxia , Mei Hongxin
Published: August 2017

A copper-catalyzed Chan–Lam-coupling-like reaction of a (het)arylboronic acid and chloramine-T (or a related compound) has been developed for the synthesis of N-arylsulfonamides at room temperature in moderate to good yields, with good tolerance of functional groups. In this process, it is believed that chloramine-T serves as an electrophile.
Spinal Canal Involvement in Solitary Infantile Myofibromatosis: Case Report
Authors: Gautam S.N. , Mittal Siddharth
Published: August 2017

Infantile myofibromatosis involving the spinal canal is very rare; only 11 cases have been reported so far in the literature. The authors present a case of an 18-month-old male child who presented with the history of dribbling of urine and weakness in bilateral lower limbs since 2 months. MRI of spine revealed single intramedullary intradural space-occupying lesion (SOL) at D1 to D2.

The patient underwent laminectomy with excision of SOL with biopsy report suggestive of benign nerve sheath tumor, and immunohistochemistry report revealed desmin negative, smooth muscle actin positive, and S-100 focally positive infantile myofibromatosis. The patient gradually recovered and had a clear stream of urine with improved movements and tone of bilateral lower limbs at the time of discharge.
Immunhämatologische und molekulargenetische Diagnostik bei einer Patientin mit multiplen Blutgruppenantikörpern und Anti-Tc(a)
Authors: Scharberg Erwin , Huck Rahel , Leimkühler Klaus , Lenz Veronika , Breyer Marianne , Bugert Peter
Published: August 2017

Eine 65-jährige Dialysepatientin, die aufgrund einer ausgeprägten Anämie nach einem operativen Eingriff eine Erythrozytentransfusion benötigte, zeigte im Rahmen der prätransfusionellen Diagnostik positive Reaktionen mit allen Testzellen im Antikörpersuchtest und in der Antikörperdifferenzierung. Alle gekreuzten Erythrozytenkonzentrate waren ebenfalls positiv in der serologischen Verträglichkeitsprobe. Da die Autokontrolle und der direkte Antiglobulintest (DAT) negativ waren, bestand der Verdacht auf einen Antikörper gegen ein hochfrequentes Blutgruppenantigen. Wegen klinisch dringender Transfusionsindikation wurden der Patientin 2 Erythrozytenkonzentrate übertragen, von denen das 1. vertragen wurde. Bei der Gabe des 2. Präparats kam es zu einer hämolytischen Transfusionsreaktion, sodass die Transfusion nach ca. 20 ml abgebrochen wurde. Bei der immunhämatologischen Abklärung reagierte das Serum der Patientin positiv mit allen Zellen mehrerer Antikörperdifferenzierungspanels, inklusive multipler Testzellen, die negativ für hochfrequente Antigene waren. Mithilfe verschiedener serologischer Untersuchungsmethoden konnten neben einem panreaktiven Alloantikörper irreguläre Antikörper mit der Spezifität Anti-c, Anti-Kp(a) und Anti-Jk(b) identifiziert werden. Vier Wochen später entwickelte die Patientin zusätzlich noch Anti-Fy(a). Die serologischen Eigenschaften des nicht mit Fremdplasma neutralisierbaren unklaren panreaktiven Antikörpers erlaubten eine Eingrenzung der infrage kommenden Spezifitäten. Inhibitionsversuche mit ausgewählten rekombinanten Blutgruppenproteinen zeigten, dass der Antikörper mit dem rekombinanten Cromer-Protein (DAF) neutralisierbar war und es sich somit um einen Antikörper gegen ein hochfrequentes Antigen aus dem Cromer-Blutgruppensystem handeln musste. Dank der Inhibition konnten die bis dahin differenzierten Antikörper bestätigt werden. Da das Cromer-Blutgruppensystem 13 bekannte hochfrequente Antigene erhält, antigennegative Testerythrozyten eine Rarität darstellen und die oben genannten begleitenden Antikörper eine genaue serologische Differenzierung des Antikörpers praktisch unmöglich machten, wurde eine Sequenzierung des Cromer-Gens (CROM) der Patientin vorgenommen. Diese ergab eine Homozygotie für die Mutation c.155G>T und damit den Phänotyp Tc(a−b+c−). Es ist also davon auszugehen, dass bei der Patientin ein Antikörper gegen das hochfrequente Merkmal Tc(a) vorliegt. Zwei Söhne der Patienten waren heterozygot für das c.155T-Allel: Sohn 1 mit c.155G>T für Tc(a+b+c−) und Sohn 2 mit c.155T>C für Tc(a−b+c+). In dieser Familie waren also das seltene Merkmal Tc(b) mütterlich und das seltene Merkmal Tc(c) väterlich vererbt.
Bestrahlung von Blutprodukten für pädiatrische Empfänger
Authors: Zimmermann Robert , Achenbach Susanne , Hauck-Dlimi Barbara
Published: August 2017

Die Gammabestrahlung von zellulären Blutkomponenten bleibt die Methode der Wahl, um eine transfusionsassoziierte Graft-versus-Host-Krankheit (TA-GvHD) zuverlässig zu verhindern. Durch die Einführung der universellen Leukozytenreduktion von zellulären Blutkomponenten und der Gammabestrahlung von Komponenten für potenziell anfällige Empfänger ist die TA-GvHD fast vollständig verschwunden. Die Lagerung von Erythrozytenkonzentraten verursacht Schädigungen der Erythrozyten, die zu Kaliumfreisetzung und Hämolyse führen. Die Gammabestrahlung beschleunigt die Kaliumfreisetzung sofort und die Zunahme der Hämolyse mit einiger zeitlicher Verzögerung. Die Konsequenzen des Lagerungsschadens und des Bestrahlungsschadens an Erythrozyten sind für die sogenannte Transfusion kleiner Volumina für Frühgeborene, Neugeborene und ältere Kinder vernachlässigbar, während bei großvolumigen Transfusionen und Transfusionen in der pädiatrischen Herzchirurgie sogar geringe Freisetzungen von Kalium kritisch sind.
Einfluss der Verschattung auf die Vitamin-D-gewichtete UV-Exposition eines Menschen
Authors: Schrempf M. , Thuns N. , Lange K. , Seckmeyer G.
Published: August 2017

Die Vitamin-D3-gewichtete UV-Exposition eines aufrecht stehenden Menschen wurde für ausgewählte urbane Umgebungen bestimmt, um den Einfluss der Verschattung durch Gebäude oder Bewuchs auf die Exposition zu untersuchen. Die Exposition wird berechnet unter Berücksichtigung der Strahldichte, also der Strahlungsenergie von direkter Sonnenstrahlung und diffuser Himmelsstrahlung aus verschiedenen Einfalls- und Azimutwinkeln und der 3 D-Geometrie eines Modellmenschen. Die Verschattung wird durch Hemisphären-Bilder bestimmt, die mithilfe einer Fotokamera mit Fischaugenobjektiv aufgenommen wurden, wobei angenommen wird, dass die Strahlung verschatteter Himmelssegmente vernachlässigbar klein ist. Dadurch werden den Himmel verdeckende Hindernisse räumlich hochaufgelöst erfasst und als Input in das Expositionsmodell eingegeben. Die Vitamin-D3-gewichtete Exposition betrug an einer bebauten Straße am 21. Dezember zu Sonnenhöchststand ungefähr 50 % und am 21. März 70 % von der Exposition einer hindernisfreien Umgebung.
Langjährige erfolglose Behandlung eines sekundären Lymphödems unter der Diagnose Acne inversa
Authors: Troyanova-Slavkova S. , Eickenscheidt L. , Eichelkraut S. , Bielfeld C. , Kowalzick L.
Published: August 2017

Wir berichten über eine 48-jährige, deutlich adipöse Patientin, die über viele Jahre unter der Diagnose einer inguinalen Acne inversa erfolglos behandelt wurde. Wegen der hierfür untypischen Anamnese und Klinik, die eher für ein chronisches Lymphödem sprach, führten wir eine bildgebende Diagnostik des Bauchraumes durch. Hierbei fand sich eine monströse intraabdominelle, vermutlich benigne Raumforderung.
Statine als Therapie bei Lebererkrankungen?
Authors: Sauerbruch Tilman , Schierwagen Robert , Trebicka Jonel
Published: August 2017

Statins have proven effects in the primary and secondary prevention of coronary disease. Besides lowering LDL-cholesterol beneficial pleiotropic consequences of statin therapy are increasingly discussed. Retrospective analyses of large cohort studies have shown favorable effects on the sequels of chronic viral induced liver disease and of non alcoholic fatty liver disease. These findings are substantiated by experimental work showing that statins reduce inflammation, fibrosis and proliferation in the diseased liver. Prospective controlled trials are necessary to elucidate whether, when and where statins have a role in the therapeutic armamentarium for liver disease.
Kennzeichnung hämatopoetischer Stammzellzubereitungen mit dem „Einheitlichen Europäischen Code“ (SEC) gemäß Richtlinie (EU) 2015/565
Authors: Wiesneth Markus
Published: August 2017

Aufgrund der Änderung des Arzneimittelgesetzes (AMG) vom 21. November 2016 sind hämatopoetische Stammzellzubereitungen (HSZZ) aus Knochenmark, peripherem Blut oder Nabelschnurblut ab dem 29. April 2017 vor dem Inverkehrbringen zur Anwendung beim Menschen gemäß der Richtlinie (EU) 2015/565 mit dem „Einheitlichen Europäischen Code“ (SEC) zu kennzeichnen. Zur leichteren Rückverfolgbarkeit werden die von den zuständigen Behörden für HSZZ lizenzierten Einrichtungen mit den jeweils autorisierten Produktarten und Tätigkeiten in einem öffentlichen Register geführt, was auch zu einer Erleichterung für das Verbringen von HSZZ aus EU-Mitgliedstaaten führen könnte. Die Gesetzesänderung wurde in der Arzneimittel- und Wirkstoffherstellungsverordnung (AMWHV) umgesetzt und wird in diesem Artikel mit Bezug auf die Kennzeichnungspflicht gemäß den Genehmigungen nach § 21 a AMG kommentiert, zumal einige Fragen zur SEC-Kennzeichnung offen bleiben.
Der komplementäre Einsatz des internetbasierten Selbstmanagementprogramms „moodgym“ bei Menschen mit depressiven Erkrankungen in der stationären Versorgung – die Perspektive von Patienten und Behandlern
Authors: Dorow Marie , Stein Janine , Förster Franziska , Löbner Margrit , Franz Michael , Günther Rolf , Schröder Rolf , Sommer Dieter , Möller Dieter , Dekoj Marie , Becker Thomas , Riedel-Heller Steffi
Published: August 2017

Ziel der Studie Erfassung der Nutzungsakzeptanz, Zugangsmöglichkeiten und -barrieren eines Online-Selbstmanagementprogramms (moodgym) für Depressionen.

Methodik Schriftliche Befragungen von n = 181 stationär behandelten Patienten (Prä-Post-Messung, 8 Wochen) und n = 31 Experten.

Ergebnisse Moderate bis hohe Nutzungsakzeptanz. Relevante Zugangsbarrieren waren geringe PC-Erfahrungen, Konzentrationsschwierigkeiten und schwere Krankheitsverläufe.

Schlussfolgerung Erstmals konnte gezeigt werden, dass Interventionen wie moodgym einen komplementären Behandlungsbaustein in der stationären Versorgung bilden könnten.
Indikationen und Evidenz von international entwickelten Online-Coaches zur Intervention bei psychischen Erkrankungen – ein Meta-Review
Authors: Stein Janine , Röhr Susanne , Luck Tobias , Löbner Margrit , Riedel-Heller Steffi
Published: August 2017

Ziel der Studie Für welche psychischen Indikationen wurden international Online-Coaches entwickelt und welche Nutzenevidenz gibt es?

Methodik Systematische Literaturrecherche, Meta-Review.

Ergebnisse Die Wirksamkeit wurde für eine Vielzahl an Online-Coaches für psychische Indikationen belegt bei überwiegend akzeptabler und hoher Qualität.

Schlussfolgerung Die vorliegende Arbeit liefert einen guten Überblick über international entwickelte Online-Coaches für psychische Indikationen. Online-Coaches stellen eine sinnvolle Ergänzung zur Behandlung und Prävention psychischer Erkrankungen dar.
Quality Standards for Herbal Drugs and Herbal Drug Preparations – Appropriate or Improvements Necessary?
Authors: Länger Reinhard , Stöger Erich , Kubelka Wolfgang , Helliwell Keith
Published: August 2017

Standards for quality control as defined in the European Pharmacopoeia contribute significantly to a consistent and high quality of herbal drugs, herbal drug preparations, and herbal medicinal products. The minimum content of single plant constituents is considered of high relevance. Therefore, nearly all monographs on herbal drugs or herbal drug preparations contain an obligatory assay.

However, a critical evaluation of the data published for such assayed constituents reveals that in most cases these constituents have to be considered as purely analytical markers without correlation to quality or efficacy. Examples where the assay does not meet its objective support the need to adapt current quality standards. Moreover, the trend to increase the content of certain constituents may lead to significant modifications to traditional manufacturing processes.

In order to initiate a scientific discussion, the role of the assay in the context of quality requirements, quality documentation in the manufacturing process, safety, and efficacy is discussed and possible alternatives to the single marker assay are examined.
All-electrical measurement of the triplet-singlet spin relaxation time in self-assembled quantum dots
Authors: Eltrudis K. , Al-Ashouri A. , Beckel A. , Ludwig A. , Wieck A. D. , Geller M. , Lorke A.
Published: August 2017

We have measured the spin relaxation time of an excited two-electron spin-triplet state into its singlet ground state in self-assembled InAs/GaAs quantum dots. We use a time-resolved measurement scheme that combines transconductance spectroscopy with spin-to-charge conversion to address the |s↑,p↑〉 triplet state, where one electron is in the quantum dot s-shell and a second one in the p-shell. The evaluation of the state-selective tunneling times from the dots into a nearby two-dimensional electron gas allows us to determine the s- and p-shell occupation and extract the relaxation time from a rate equation model. A comparably long triplet-to-singlet spin relaxation time of 25 μs is found.
Mesh parameters influence on transparent and active antennas performance at microwaves
Authors: Martin Alexis , Castel Xavier , Himdi Mohamed , Lafond Olivier
Published: August 2017

Optically transparent and active square loop coplanar antennas operating in X-band are investigated in this letter. The frequency tunability is provided by a surface mounted beam-lead varactor with micrometric size, thereby no-visible to the naked eye. The influence of the metal mesh parameters on the sheet resistance (from 0.05 Ω/sq to 0.54 Ω/sq), the optical transparency (from 66% to 89%) and the microwave performance (return loss, resonance frequency, radiation pattern and gain) of such antennas is evaluated, compared with those of an opaque counterpart, and finally discussed. This study paves the way of their promising implementation on new surfaces, namely building and car windows for future wireless communications systems.
The nature of three-body interactions in DFT: Exchange and polarization effects
Authors: Hapka Michał , Rajchel Łukasz , Modrzejewski Marcin , Schäffer Rainer , Chałasiński Grzegorz , Szczęśniak Małgorzata M.
Published: August 2017

We propose a physically motivated decomposition of density functional theory (DFT) 3-body nonadditive interaction energies into the exchange and density-deformation (polarization) components. The exchange component represents the effect of the Pauli exclusion in the wave function of the trimer and is found to be challenging for density functional approximations (DFAs). The remaining density-deformation nonadditivity is less dependent upon the DFAs. Numerical demonstration is carried out for rare gas atom trimers, Ar2–HX (X = F, Cl) complexes, and small hydrogen-bonded and van der Waals molecular systems. None of the tested semilocal, hybrid, and range-separated DFAs properly accounts for the nonadditive exchange in dispersion-bonded trimers. By contrast, for hydrogen-bonded systems, range-separated DFAs achieve a qualitative agreement to within 20% of the reference exchange energy. A reliable performance for all systems is obtained only when the monomers interact through the Hartree-Fock potential in the dispersion-free Pauli blockade scheme. Additionally, we identify the nonadditive second-order exchange-dispersion energy as an important but overlooked contribution in force-field-like dispersion corrections. Our results suggest that range-separated functionals do not include this component, although semilocal and global hybrid DFAs appear to imitate it in the short range.
Morphology-dependent photo-induced polarization recovery in ferroelectric thin films
Authors: Wang J. Y. , Liu G. , Sando D. , Nagarajan V. , Seidel J.
Published: August 2017

We investigate photo-induced ferroelectric domain switching in a series of Pb(Zr0.2Ti0.8)O3/La0.7Sr0.3MnO3 (PZT/LSMO) bilayer thin films with varying surface morphologies by piezoresponse force microscopy under light illumination. We demonstrate that reverse poled ferroelectric regions can be almost fully recovered under laser irradiation of the PZT layer and that the recovery process is dependent on the surface morphology on the nanometer scale. The recovery process is well described by the Kolmogorov-Avrami-Ishibashi model, and the evolution speed is controlled by light intensity, sample thickness, and initial write voltage. Our findings shed light on optical control of the domain structure in ferroelectric thin films with different surface morphologies.
Transferring linear motion of an optical wedge to rotational frequency shift in an orbital angular momentum interferometer
Authors: Jia Qikun , Qiu Xiaodong , Wu Ziwen , Zhang Wuhong , Chen Lixiang
Published: August 2017

We build a modified Mach-Zehnder (M-Z) interferometer with an embedded Dove prism in one arm to observe the interference between two conjugate orbital angular momentum (OAM) beams. By inserting and moving an optical wedge vertically in the other arm, we find that its linear motion can induce a rotational frequency shift equivalently, as a consequence of phase transfer from the path difference to the azimuthal difference between two OAM beams. The micron-scale movement of the wedge is driven by a compact motorized translation stage and is manifested by a significant rotation of the interference petal-like patterns. Our scheme offers an accurate method to measure the optical wedge angle with a simple method of digital image processing. This work may also find potential applications in the field of velocity sensing or temperature sensing.