bluuebunny/crossref_metadata_2025 huggingface dataset:
Polyphenol-based nuclear magnetic resonance non-targeted metabolomics of temperature- and time-controlled blue and red maize sprouting
Authors: Carreño-Carrillo Carlos Vidal , Sánchez Evert Villanueva , Verduzco Clemente Villanueva , Herbert-Pucheta José Enrique
Published: February 2021

Zea mays L corps apport to human consumption, complex matrices of compounds such as free and bounded phenolics, flavonoids and anthocyanins with high nutritional values and proved health benefits, which are dynamically synthesized since sprouting of grains. This study presents for the first time a Nuclear Magnetic Resonance (NMR) non-targeted metabolomics study of aqueous methanolic extracts of Mexican native blue and red Zea mays L. sprouts, produced with a specific germination scheme, at three different controlled temperatures. The proposed model comprises the rationalization of (poly)-phenolics metabolism dynamics as a function of sprouting time and temperature, which can be identified by more than thirty 1H NMR discriminant resonances at a chemical shift range between 7.7 and 6.3 ppm -mostly comprising typical hydroxyphenyl polyphenolic 1H frequencies- obtained with multivariate statistical analysis. Both principal component (PCA) and orthogonal projections to latent structures discriminant analysis (OPLS-DA) reveal a unique maize strain-, temperature- and time-dependent mapping of polyphenolic machinery during sprouting that might serve for optimizing germination schemes. Strengths and limitations of PCA and OPLS-DA analysis of non-targeted (poly)-phenolics NMR data matrix obtained from different blue and red maize sprouts’ methanolic extracts are discussed. Furthermore, a clear inverse correlation between temperature- and time-dependent signal intensity modulation of phenolic resonances and water line widths at half height is observed, suggesting a mechanism of how solvent could participate within the complex metabolomic matrix formation during germination. Finally, non-targeted NMR metabolomics data from sprouts’ methanolic extracts are contrasted with temperature- and time-dependent total phenolic contents obtained with standard quantitative methods.
Multiple Sclerosis
Authors: Perez Carlos A. , Smith Andrew , Nelson Flavia
Published: February 2021

Affecting an estimated 2.5 million people worldwide, multiple sclerosis (MS) is the most common neurological cause of debilitation in young adults. Incurable, and with the precise causes still unknown, both diagnosis and management of the condition is complicated. This book summarizes the latest understanding of the causes of the disease, using accessible, bullet-point text to describe key clinical features and diagnostic criteria. Disease-modifying therapies and management of symptoms, including fatigue, tremor and cognitive changes, are covered in detail. With a chapter focusing solely on presentations in the emergency room, the importance of recognizing these neurological emergencies is emphasised, along with indications for admission in MS patients. The impact of MS on women's reproductive health and the increasing recognition of MS in pediatric patients is also explored. An up-to-date and practical approach to the accurate diagnosis and management of MS, this is an invaluable resource for both hospital and outpatient settings.
Engineering the Future, Understanding the Past
Authors: Davids Mila , Oldenziel Ruth , van der Vleuten Erik
Published: February 2021

Technology today is often presented as our best hope of solving the world's social and sustainability problems. And that's nothing new: engineers have always sought to meet the big challenges of their times-even as those challenges have shaped their technology. This book offers a historical look at those interactions between engineering and social challenges, showing how engineers developed solutions to past problems, and looking at the ways that those solutions often bring with them unintended consequences that themselves require solving.
A “Leaky” Pipeline and Chilly Climate in Archaeology in Canada
Authors: Overholtzer Lisa , Jalbert Catherine L.
Published: February 2021

This article quantifies the rate at which women archaeologists are present and retained in university departments. Drawing on publicly available data, we examine gender representation in (1) doctorates earned between 2002–2003 and 2016–2017; (2) Social Sciences and Humanities Research Council (SSHRC) grant applications and awards at the doctoral to senior levels between 2003 and 2017; (3) tenure-stream faculty at Canadian universities in 2019; and (4) placement of Canadian PhDs in the United States. These data demonstrate that women today represent two-thirds of all Canadian doctorates in archaeology, but only one-third of Canadian tenure-stream faculty, although not all archaeologists choose an academic career. In the last 15 years, women with Canadian PhDs have been hired into tenure-track positions in Canada at rates statistically lower than men, but at higher rates in the United States. Women apply for SSHRC archaeology grants in equal proportion to their presence, but men are awarded at a slightly higher rate. We end by discussing the possible reasons for this gendered attrition, including a “chilly climate”—that is, subtle practices that stereotype, exclude, and devalue women, as well as inhospitable working environments, particularly for primary caregivers. We warn that the current COVID-19 pandemic is likely to exacerbate these existing inequalities.
Addressing Fundamental Uncertainty in Benefit–Cost Analysis: The Case of Deep Seabed Mining
Authors: Krutilla Kerry , Good David , Toman Michael , Arin Tijen
Published: February 2021

Mineral deposits of base metals, precious metals, and rare earth elements have been discovered on deep seabeds, and the commercial exploitation of these resources seems poised to begin after faltering for many years. The development of seabed resources could be socially beneficial if all goes well, but the industry faces daunting challenges and uncertainties. Emerging regulations and contracting mechanisms are the principal means for managing these uncertainties. This article recommends a complementary approach: the use of ex ante benefit–cost analysis of proposed seabed mining contracts that incorporates a fundamental uncertainty evaluation. We argue that such an ex ante evaluation will improve the state of information for the decision-making, reducing the risk of regulatory noncompliance or costly contract disputes after seabed mining begins.
Go Your Own Way: The Pathways to Exiting the European Union
Authors: Ejrnæs Anders , Jensen Mads Dagnis
Published: February 2021

Studies have suggested that people voting for Brexit were motivated by anti-globalization, anti-multiculturalism and anti-elite sentiments. However, little is known about how these factors are related and whether citizens in other member states share similar reasons for wanting to exit the EU. Methodologically, this question is addressed by utilizing path models on data from the European Social Survey, with respondents in 17 countries. Empirically, this article reveals considerable cross-country variation, which implies that motivations for voting Leave should be assessed on a country-by-country basis. Yet, two main pathways are identified. First, lower education is related to more negative attitudes towards multiculturalism, which increases the probability of voting Leave. Second, lower income decreases the level of trust in the political establishment, which again increases the probability of voting Leave. Theoretically, this implies that the anti-globalization model is subsumed by the anti-multiculturalism and anti-elite models, giving rise to two new mechanisms.
Hate Speech Prosecution of Politicians and its Effect on Support for the Legal System and Democracy
Authors: Rekker Roderik , van Spanje Joost
Published: February 2021

This study examined if and for whom prosecution of politicians for hate speech undermines support for the legal system and democracy. Three research designs were combined to investigate the case of Dutch politician Geert Wilders, who was convicted for hate speech against minorities in 2016. First, an experiment showed that observing a guilty verdict decreased support among ‘assimilationists’ who oppose the multicultural society. This deterioration of support was found among the entire group of assimilationists, regardless of whether they voted for Wilders. Secondly, a quasi-experiment demonstrated that assimilationists who were interviewed after Wilders' conviction indicated less support than those who were interviewed before the verdict and compared to a pre-test. Thirdly, a nine-year panel study suggested that these effects accumulate into long-term discontent. This case therefore demonstrates that hate speech prosecution can damage the democratic system it is intended to defend.
STATE-BUILDING, CONQUEST, AND ROYAL SOVEREIGNTY IN PRUSSIA, 1815–1871
Authors: HEINZEN JASPER
Published: February 2021

Since Bodin, scholars have been debating whether sovereignty is indivisible or rather decentred, multiple, and shared. This article adds to practice-oriented conceptualizations of sovereignty, which acknowledge the existence of jurisdictional pluralism in nineteenth-century state-building. Borrowing from imperial history, it contrasts the nominal supremacy of the Prussian crown – as embodied by the monarchical principle – with the residual sovereign rights of potentates that had lost their lands in Germany's successive wars of unification. The possession of ‘bare sovereignty’ allowed such mediatized princes and exiled rulers to maintain a presence in the lives of their former subjects. They did so by exercising privileges and functions of royalty which left vague in whose name was being governed. The Hohenzollerns for their part struggled (and to a certain extent proved unwilling) to assert exclusive dominion because right of conquest-based justifications had no firm standing in international law, alienated segments of domestic public opinion, and did not necessarily serve the interests of the state. The article argues, ultimately, that the resulting negotiation and contestation of monarchical sovereignty in Prussia speaks to global themes of state-building through state destruction in the Age of Empire.
Migration history and risk of psychosis: results from the multinational EU-GEI study
Authors: Tarricone Ilaria , D'Andrea Giuseppe , Jongsma Hannah E. , Tosato Sarah , Gayer-Anderson Charlotte , Stilo Simona A. , Suprani Federico , Iyegbe Conrad , van der Ven Els , Quattrone Diego , di Forti Marta , Velthorst Eva , Rossi Menezes Paulo , Arango Celso , Parellada Mara , Lasalvia Antonio , La Cascia Caterina , Ferraro Laura , Bobes Julio , Bernardo Miguel , Sanjuán Iulio , Santos Jose Luis , Arrojo Manuel , Del-Ben Cristina Marta , Tripoli Giada , Llorca Pierre-Michel , de Haan Lieuwe , Selten Jean-Paul , Tortelli Andrea , Szöke Andrei , Muratori Roberto , Rutten Bart P. , van Os Jim , Jones Peter B. , Kirkbride James B. , Berardi Domenico , Murray Robin M. , Morgan Craig
Published: February 2021

Background

Psychosis rates are higher among some migrant groups. We hypothesized that psychosis in migrants is associated with cumulative social disadvantage during different phases of migration.

Methods

We used data from the EUropean Network of National Schizophrenia Networks studying Gene-Environment Interactions (EU-GEI) case–control study. We defined a set of three indicators of social disadvantage for each phase: pre-migration, migration and post-migration. We examined whether social disadvantage in the pre- and post-migration phases, migration adversities, and mismatch between achievements and expectations differed between first-generation migrants with first-episode psychosis and healthy first-generation migrants, and tested whether this accounted for differences in odds of psychosis in multivariable logistic regression models.

Results

In total, 249 cases and 219 controls were assessed. Pre-migration (OR 1.61, 95% CI 1.06–2.44, p = 0.027) and post-migration social disadvantages (OR 1.89, 95% CI 1.02–3.51, p = 0.044), along with expectations/achievements mismatch (OR 1.14, 95% CI 1.03–1.26, p = 0.014) were all significantly associated with psychosis. Migration adversities (OR 1.18, 95% CI 0.672–2.06, p = 0.568) were not significantly related to the outcome. Finally, we found a dose–response effect between the number of adversities across all phases and odds of psychosis (⩾6: OR 14.09, 95% CI 2.06–96.47, p = 0.007).

Conclusions

The cumulative effect of social disadvantages before, during and after migration was associated with increased odds of psychosis in migrants, independently of ethnicity or length of stay in the country of arrival. Public health initiatives that address the social disadvantages that many migrants face during the whole migration process and post-migration psychological support may reduce the excess of psychosis in migrants.
Time-dependent depression and anxiety symptoms as risk factors for recurrent cardiac events: findings from the UPBEAT-UK study
Authors: Norton Joanna , Pastore Manuela , Hotopf Matthew , Tylee Andre , Mann Anthony , Ancelin Marie-Laure , Palacios Jorge
Published: February 2021

Background

Depression is a well-known risk factor for recurrent cardiac events (RCEs) but findings are less consistent for anxiety, not previously reported on using a time-dependent approach. We aimed to study the prognostic effect of anxiety and depression symptom levels on RCEs.

Methods

Data (N = 595) were drawn from the UPBEAT-UK heart disease patient cohort with 6-monthly follow-ups over 3 years. Hospital Anxiety and Depression Scale symptoms were grouped into: agitation (three items), anxiety (four items), and depression (seven items) subscales. We performed two types of multivariate analyses using Cox proportional hazard models with delayed entry: with baseline variables (long-term analysis), and with variables measured 12-to-18 months prior to the event (short-term time-dependent analysis), as RCE risk factors.

Results

In the baseline analysis, both anxiety and depression, but not agitation, were separate RCE risk factors, with a moderating effect when considered jointly. In the short-term time-dependent analysis, elevated scores on the anxiety subscale were associated with increased RCE risk even when adjusted for depression [hazard ratio (95% confidence interval) 1.22 (1.05–1.41), p = 0.009]. Depression was no longer a significant predictor when adjusted for anxiety [1.05 (0.87–1.27), p = 0.61]. For anxiety, individual items associated with RCEs differed between the two approaches: item 5 ‘worrying thoughts’ was the most significant long-term risk factor [1.52 (1.21–1.91), p = 0.0004] whereas item 13 ‘feelings of panic’ was the most significant time-dependent short-term risk factor [1.52 (1.18–1.95), p = 0.001].

Conclusions

Anxiety is an important short-term preventable and potentially causal risk factor for RCEs, to be targeted in secondary cardiac disease prevention programmes.
Pivotal clinical trial enrollment of Blacks in multiple sclerosis or neuromyelitis spectrum disorder: when will we achieve parity?
Authors: Avasarala Jagannadha , Zachariah Phenu , Turner Breck
Published: February 2021

Patient enrollment in people of color among pivotal trials for multiple sclerosis (MS) and neuromyelitis spectrum disorder (NMOSD) continues to be dismal. It is disappointing that no clinical trial sponsored by a pharmaceutical industry or otherwise, investigating any of the disease-modifying drugs, has tackled this glaring inequity head on. The disease characteristics and phenotype of MS or NMOSD among Blacks and Hispanics are typically aggressive and for this reason alone, if not for any other metric, there needs to a radical shift in allotment of funds devoted to promoting drug research in minority populations.
Feasibility of commercially available underwear during radiation therapy for breast cancer: build-up and surface dose measurements
Authors: Hama Yukihiro
Published: February 2021

Aim:

When patients receive radiation therapy for breast cancer, they need to take off their underwear to avoid build-up effects. However, it is a mental burden for female patients to take off their underwear at every fraction of radiation therapy. The purpose of this study was to investigate whether commercially available thin underwear can be worn during radiation therapy for breast cancer.

Materials and methods:

In this phantom study, we investigated whether commercially available underwear can be worn during radiation therapy for breast cancer using six thin non-disposable brassieres and one disposable paper brassiere. The dose increase rate (ΔD) was calculated by measuring skin doses with or without each brassiere.

Results:

The mean ΔD values of six non-disposable brassieres were 13.5% (9.0–21.8%), whereas that of disposable ones was 2.0%.

Findings:

Due to the risk of excessive radiation to the skin, wearing commercially available underwear is not recommended during radiation therapy for breast cancer, but a thin disposable paper brassiere may be safe to be used.
Dead, but Won’t Lie Down? Grammatical Gender among Norwegians
Authors: Opsahl Toril
Published: February 2021

This paper examines grammatical gender from the sociolinguistic perspective. The question pursued is to what extent exponents of grammatical gender are tied indexically to identity categories. Building on literature and corpus data, I claim that within the Norwegian context, grammatical gender is associated with sociolinguistic dimensions such as the urban/rural distinction, political views, class, ethnicity. The traditional three-gender system is being replaced by a two-gender system in several dialects, resulting in the loss of the feminine gender. Indexical values associated with the feminine gender features are still valid, though, and some forms take on new pragmatic functions. Once grammatical gender is viewed through a sociolinguistic lens, with the agency of speakers being recognized, it becomes clear that it may not be fully understood without taking into account the context of interaction at a micro-level, and the sociohistorical characteristics of—for instance—regions with language contact at a macro-level.*
Sick and Vulnerable Migrants in French Public Hospitals. The Administrative and Budgetary Dimension of Un/Deservingness
Authors: Geeraert Jérémy
Published: February 2021

This article explores how staff in French public hospitals are indirectly involved in the governing of migration through healthcare. It unpacks the construction of differentiated values of life assigned to specific categories of vulnerable (authorised and unauthorised) migrants according to their perceived un/deservingness in context of budgetary restrictions. This context emphasises tensions between medical and administrative staff in the decision-making process regarding access to healthcare. The analysis rests upon empirical data (participant observations and semi-directed interviews) gathered in ‘healthcare access units’ located in public hospitals. Perceptions of un/deservingness lead to both healthcare rationing and healthcare denial and are built upon entangled criteria related to both migration status and budgetary concerns. These mechanisms reveal the administrative and budgetary dimensions that underlie the perceptions of health-related un/deservingness, which is linked to the costs of healthcare: the higher the costs, the less likely patients are to be designated to be deserving of healthcare.
Laissez les bons temps rouler? The persistent effect French civil law has on corruption, institutions, and incomes in Louisiana
Authors: Callais Justin T.
Published: February 2021

Louisiana consistently ranks as one of the most corrupt states in the nation. In fact, the Pelican State is the most corrupt state when looking at the most common indicator of corruption: corruption convictions per 100,000. What is less clear about Louisiana is how the state became corrupt. This paper seeks to provide the missing link. I argue that the high levels of corruption in the state can be explained by its origins in French civil law. This historical influence has perverse and persistent effects on the state, despite occurring over 200 years ago. Through these origins in civil law, corruption in Louisiana impacts its economic institutions. These institutions then lead to a variety of other bad outcomes in the state such as a high dependency on oil and low incomes. This argument implies that resource dependency is bad for development only when institutional quality is low. By linking legal origins to corruption, institutions, and economic outcomes, I seek to offer a clearer explanation for why Louisiana sets itself apart from other states in its politically corrupt environment.
Corruption and SME growth: the roles of institutional networking and financial slack
Authors: Adomako Samuel , Ahsan Mujtaba , Amankwah-Amoah Joseph , Danso Albert , Kesse Kwabena , Frimpong Kwabena
Published: February 2021

In this study, we investigate the mediating effect of institutional networking on the relationship between perceived corruption and the growth of small and medium-sized enterprises (SMEs). We also examine the moderating impact of financial slack on the relationship between perceived corruption and institutional networking. We test our moderated mediation model using data from 212 SMEs operating in Ghana. The findings from the study show that perceived corruption is positively related to institutional networking and this relationship is amplified when levels of financial slack are greater. The findings also show that institutional networking positively mediates the relationship between perceived corruption and SME growth. Theoretical and practical implications are discussed.
Die Rolle elternbeurteilter exekutiver Funktionen zur Schulleistungsprognose
Authors: Michel Eva , Söll Lena , Molitor Sabine
Published: February 2021

Zusammenfassung. Einleitung: Unter dem Begriff exekutive Funktionen (EF) werden häufig die Komponenten Inhibition, kognitive Flexibilität und Aktualisierung von Arbeitsgedächtnisrepräsentationen subsumiert. EF sind bereichsübergreifende Prädiktoren schulischer Leistungen. Verschiedene Operationalisierungen derselben Komponente, z.B. Performanztests und Elterneinschätzungen, zeigen häufig nur geringe Interkorrelationen. Die Methoden scheinen unterschiedliche Aspekte einer Komponente zu erfassen, daher könnte eine Kombination zur Vorhersage schulischer Leistungen sinnvoll sein. Methode: N = 96 Erst- und Zweitklässler_innen mit und ohne Entwicklungsauffälligkeiten wurden mittels EF-Performanztests und Schulleistungstests zu Mathematik und Lesen untersucht. Per Fragebogen wurden elternbeurteilte EF und als Kontrollvariablen der sozioökonomische Status (SÖS) und das Vorliegen von Merkmalen einer Aufmerksamkeitsdefizit-Hyperaktivitätsstörung (ADHS) erfasst. Ergebnisse: Elternbeurteilungen hatten über die Performanztests hinaus einen bedeutsamen Vorhersagewert für die Mathematik- und Leseleistung. Der Einfluss von Alter, SÖS und ADHS-Merkmalen wurde kontrolliert. Diskussion: Die kombinierte Anwendung beider Erfassungsmethoden scheint somit vorteilhaft für die Prognose schulischer Leistungen und die Prävention von Schulleistungsproblemen.
Aftercare and Suicide Reattempt Prevention in Tehran, Iran
Authors: Malakouti Seyed Kazem , Nojomi Marzieh , Ghanbari Behrooz , Rasouli Nafee , Khaleghparast Shiva , Farahani Ida Ghaemmagham
Published: February 2021

Abstract. Background: A previous suicide attempt is one of the strongest risk factors for subsequent suicide. Effective care following a suicide attempt may reduce the risk of suicide reattempts. Aims: We aimed to investigate the effect of a brief educational intervention and contact program on suicide reattempts. Method: This study was performed as a randomized clinical trial (RCT) recruiting 305 individuals who had attempted suicide (brief intervention and contact = 153 individuals, BIC; treatment as usual = 152 individuals, TAU) who were referred to Baharlu Hospital in Tehran. The SUPRE-MISS questionnaire and a discharge follow-up questionnaire were used for data collection. Cox proportional hazard models and log-rank tests were used to assess the association of the variable with the event (reattempt). Kaplan–Meier curves were used to depict the time to the event of reattempt. Results: In the BIC group, 11% of the individuals had attempted suicide once, and 25% of the TAU group had attempted suicide once (12.4%), twice (9.3%), and three times (3.8%), respectively. The results of Kaplan–Meier analysis indicated the mean time of reattempt in the BIC (0.76) and TAU groups (0.25) as the fourth and second months of follow-up, respectively (log rank, χ2 = 12.48, p < .001). The hazard ratio for the TAU group was 2.57 (95% CI [1.4, 5.9]). Limitations: Loss to follow-up due to stigma is one of the serious problems of follow-up services. Conclusion: Implementing a brief educational intervention and contact program on suicide reattempts is feasible and effective in reducing the rate of reattempt; however, it should be accommodated within the mental health services of the county.
Live-Chat Support for People Bereaved by Suicide
Authors: Cipolletta Sabrina , Entilli Lorenza , Bettio Fabio , De Leo Diego
Published: February 2021

Abstract. Background: People bereaved by suicide often face isolation, complicated grief, and increased suicide risk. Aims: We aimed to explore how live-chat can support survivors in their bereavement process. Method: A thematic analysis was carried out on 30 live-chat conversations through the software ATLAS.ti8. Transcripts were retrieved from a major Italian association providing online support. The users had different ages (18–60 years), degrees of kinship with the deceased (blood-related and not), and time distance from the loss (between 48 hr and 10 years). Results: Five themes were identified: meaning-making, reactions to the loss, resources, needs, and interactions with the operator. Survivors used the live-chat as a safe space in which to disclose nonsocially desirable details and to make sense of suicide through the reconstruction of events and the deceased's motivations. Given the limited social resources and the dissatisfaction with the available formal support, users resorted to justification, rationalization, or faith and found support and reassurance in the live chats. Limitations: Some conversations were fragmented and lacked detailed information on the users. Conclusion: Because of their anonymity and accessibility, live-chats represent a valid first-line form of support, from which survivors may obtain useful information and start a meaning-making process.
Suicide Exposure in Crisis Workers
Authors: Long Molly M. , Cerel Julie , Aldrich Rosalie S. , Kheibari Athena
Published: February 2021

Abstract. Background: Crisis workers provide services to individuals who are in acute distress. There is no research examining personal and occupational exposure to suicide in these workers. Aims: We aimed to examine the prevalence of personal, occupational, and colleague suicide exposure among crisis workers, the mental health outcomes associated with suicide exposures, and perceived professional preparedness for client suicide. Method: Crisis workers ( n = 115) completed an online survey assessing suicide exposure, depression, anxiety, and posttraumatic stress disorder. Results: Over a third of participants (33.9%, n = 37) reported that they had lost at least one client to suicide, with an average of 2.30 clients ( SD = 4.47) lost to suicide. Over three quarters (77.1%, n = 81) of study participants reported they had experienced at least one personal loss to suicide. Those who perceived their relationship to the personal suicide as close or very close had significantly greater PTSD symptoms ( M = 3.29, SD = 2.23) than those who perceived their relationship as not at all close, not close, or somewhat close ( M = 1.38, SD = 1.69), t(20) = −2.10, p = .049. Limitations: Snowball sampling is the study's main limitation. Conclusion: The current study demonstrates that a substantial percentage of crisis workers are exposed to suicide and additional research is needed to determine how exposures impact practice and personal symptoms in this population.
The Need for Collective Awareness of Attempted Suicide Rates in a Warming Climate
Authors: Giacomini Gabriele , Aguglia Andrea , Amerio Andrea , Escelsior Andrea , Capello Marco , Cutroneo Laura , Ferretti Gabriele , Scafidi Davide , Serafini Gianluca , Amore Mario
Published: February 2021

Abstract. Background: Climate factors may offer a stronger explanation of the variations in suicide rates compared with economic variables, even in the case of patients admitted involuntarily. Aims: We assessed the role of temperature as a determinant of the increased prevalence of suicide attempts (SA). Method: The sample comprised all cases of hospitalization for SA at the Psychiatric Clinic of the IRCCS Ospedale Policlinico San Martino between August 2013 and July 2018. For ambient temperature, data were provided by the Meteorological Observatory of the University of Genoa. Results: We noted a peak in suicides that was typically found in late spring and early summer due to global warming. Limitations: Other environmental/psychological factors contributing to the onset of an acute clinical event were not considered. The cross-sectional design of the study is another limitation. Conclusion: Further studies are needed to clarify the impact of climatic factors on suicide behavior and implement early intervention and preventive strategies for mental health.
Martian Hydrated Minerals: A Significant Water Sink
Authors: Wernicke Liza J. , Jakosky Bruce M.
Published: February 2021

Quantifying the water in all Martian water reservoirs is important for understanding the history of water on Mars, including Mars’ past climate and potential for habitability. Hydrated minerals are widespread on Mars and may comprise a significant portion of the water inventory. We calculated the possible volumes of water stored within and required to form hydrated minerals on Mars by estimating the weight percent (wt.%) water of ice‐free, near‐surface materials, the wt.% water required to form subsurface hydrated minerals, and the densities and thicknesses of rock units with hydrated minerals. We estimated the near‐surface wt.% water using Mars Odyssey Neutron Spectrometer and OMEGA 3 µm hydration feature surveys. We calculated the wt.% water required to form subsurface hydrated minerals by estimating: (1) percent occurrences of subsurface hydrated minerals using mineralogical crater surveys, (2) abundance per detection of hydrated minerals using published spectral unmixing results of hydrated mineral detections, and (3) the wt.% water required to form hydrated minerals using estimated masses and hydration states of hydrated minerals. We estimated the densities of rock units with hydrated minerals using prior crustal density estimates and measurements of sedimentary rock density in Gale Crater. We estimated the thicknesses of rock units with hydrated minerals using mineralogical crater surveys. Our best estimate for the volume of water stored within or required to form hydrated minerals on Mars is 130–260 m global equivalent layer (GEL) and our plausible range extends from 70–860 m GEL. Compared to other Martian reservoirs, hydrated minerals are a significant water sink.
The Application of Ensemble Wave Forcing to Quantify Uncertainty of Shoreline Change Predictions
Authors: Vitousek Sean , Cagigal Laura , Montaño Jennifer , Rueda Ana , Mendez Fernando , Coco Giovanni , Barnard Patrick L.
Published: February 2021

Reliable predictions and accompanying uncertainty estimates of coastal evolution on decadal to centennial time scales are increasingly sought. So far, most coastal change projections rely on a single, deterministic realization of the unknown future wave climate, often derived from a global climate model. Yet, deterministic projections do not account for the stochastic nature of future wave conditions across a variety of temporal scales (e.g., daily, weekly, seasonally, and interannually). Here, we present an ensemble Kalman filter shoreline change model to predict coastal erosion and uncertainty due to waves at a variety of time scales. We compare shoreline change projections, simulated with and without ensemble wave forcing conditions by applying ensemble wave time series produced by a computationally efficient statistical downscaling method. We demonstrate a sizable (site‐dependent) increase in model uncertainty compared with the unrealistic case of model projections based on a single, deterministic realization (e.g., a single time series) of the wave forcing. We support model‐derived uncertainty estimates with a novel mathematical analysis of ensembles of idealized process models. Here, the developed ensemble modeling approach is applied to a well‐monitored beach in Tairua, New Zealand. However, the model and uncertainty quantification techniques derived here are generally applicable to a variety of coastal settings around the world.
Development and Operation of an Ocean Bottom Cable Seismic and Tsunami (OBCST) Observation System in the Source Region of the Tohoku‐oki Earthquake
Authors: Shinohara Masanao , Yamada Tomoaki , Uehira Kenji , Sakai Shin'ichi , Shiobara Hajime , Kanazawa Toshihiko
Published: February 2021

Cabled seafloor seismic and tsunami observation systems are ideal for marine geophysical monitoring because the data can be obtained in real time. We have developed a new compact seafloor‐cable seismic and tsunami observation system using Information and Communication Technology (ICT). Our system achieves reliability through redundancy using ICT. A software‐based system using up‐to‐date electronics technology contributes to cost reduction and production sustainability. The system named the Ocean Bottom Cable Seismic and Tsunami (OBCST) observation system was installed on the Pacific Ocean floor off Sanriku, northeast Japan, in September 2015, in the source area of the 2011 Tohoku‐oki earthquake. The purpose of the installation is to monitor seismic activity better and to observe tsunami activity through spatially dense observation. The system has been continuously collecting the seismic and pressure data since the deployment. For the seismic data, ambient seismic noise is comparable to that from a previous cable observation system. One observation node is buried 1 m below the seafloor and has a lower noise level compared to nodes on the seafloor. Because the noise levels are stable, many local earthquakes and teleseismic events have been recorded by the system. The data obtained by high‐precision pressure gauges have a resolution of <1 hPa which is limited to environmental noise. The effectiveness of the buried pressure gauge is demonstrated by a recording of a tsunami. The system also continuously monitors its operating environment. The operating temperature is reasonably low and stable, which is optimal for long‐term operation.
Performance of RegCM4 for Dynamically Downscaling of El Nino/La Nina Events During Southwest Monsoon Over India and Its Regions
Authors: Verma Shruti , Bhatla R.
Published: February 2021

This study presents the interannual variation in the summer monsoon rainfall during the El Nino Southern Oscillation (ENSO) phases, that is, El Nino and La Nina throughout the Indian subcontinent and its subregions during 1986–2010. The analysis includes the performance assessments of the regional climate model (RegCM4) in simulating Indian summer monsoon rainfall through comparison with India Meteorological Department rainfall data. Observation clearly demonstrates that the El Nino/La Nina produced weaker/strong monsoon rainfall over India and it increases the interannual variability of the southwest monsoon. The capability and skill of RegCM4's Grell and Mix99 cumulus parameterization scheme in simulating Indian summer monsoon rainfall associated with extreme climate are usually higher in “dry” conditions rather below average for the accurate simulation of “wet” conditions. Also, model performance was good in defining the characteristics, spatial distribution, and trend of a dry spell during ENSO phases with observation. The model‐simulated spatial and temporal value of wet spell during ENSO produces overestimated value over all India.
Spurious Rollover of Wave Attenuation Rates in Sea Ice Caused by Noise in Field Measurements
Authors: Thomson Jim , Hošeková Lucia , Meylan Michael H. , Kohout Alison L , Kumar Nirnimesh
Published: February 2021

The effects of instrument noise on estimating the spectral attenuation rates of ocean waves in sea ice are explored using synthetic observations in which the true attenuation rates are known explicitly. The spectral shape of the energy added by noise, relative to the spectral shape of the true wave energy, is the critical aspect of the investigation. A negative bias in attenuation that grows in frequency is found across a range of realistic parameters. This negative bias decreases the observed attenuation rates at high frequencies, such that it can explain the rollover effect commonly reported in field studies of wave attenuation in sea ice. The published results from five field experiments are evaluated in terms of the noise bias, and a spurious rollover (or flattening) of attenuation is found in all cases. Remarkably, the wave heights are unaffected by the noise bias, because the noise bias occurs at frequencies that contain only a small fraction of the total energy.
Changes in Clear‐Sky Shortwave Aerosol Direct Radiative Effects Since 2002
Authors: Loeb Norman G. , Su Wenying , Bellouin Nicolas , Ming Yi
Published: February 2021

A new method for determining clear‐sky shortwave aerosol direct radiative effects (ADRE) from the Clouds and the Earth's Radiant Energy System is used to examine changes in ADRE since 2002 alongside changes in aerosol optical depth (AOD) from the Moderate Resolution Spectroradiometer. At global scales, neither ADRE nor AOD show a significant trend. Over the northern hemisphere (NH), ADRE increases by 0.18 ± 0.17 Wm−2 per decade (less reflection to space) but shows no significant change over the southern hemisphere. The increase in the NH is primarily due to emission reductions in China, the United States, and Europe. The COVID‐19 shutdown shows no noticeable impact on either global ADRE or AOD, but there is a substantial influence over northeastern China in March 2020. In contrast, February 2020 anomalies in ADRE and AOD are within natural variability even though the impact of the shutdown on industry was more pronounced in February than March. The reason is because February 2020 was exceptionally hot and humid over China, which compensated for reduced emissions. After accounting for meteorology and normalizing by incident solar flux, February ADRE anomalies increase substantially, exceeding the climatological mean ADRE by 23%. February and March 2020 correspond to the only period in which adjusted anomalies exceed the 95% confidence interval for 2 consecutive months. Distinct water‐land differences over northeastern China are observed in ADRE but not in AOD. This is likely due to the influence of surface albedo on ADRE in the presence of absorbing aerosols.
Studying the Global Spatial Randomness of Impact Craters on Mercury, Venus, and the Moon With Geodesic Neighborhood Relationships
Authors: Riedel C. , Michael G. G. , Orgel C. , Baum C. , van der Bogert C. H. , Hiesinger H.
Published: February 2021

Impact crater records on planetary surfaces are often analyzed for their spatial randomness. Generalized approaches such as the mean second closest neighbor distance (M2CND) and standard deviation of adjacent area (SDAA) are available via a software tool but do not take the influence of the planetary curvature into account in the current implementation. As a result, the measurements are affected by map distortion effects and can lead to wrong interpretations. This is particularly critical for investigations of global data sets as the level of distortion typically increases with increasing distance from the map projection center. Therefore, we present geodesic solutions to the M2CND and SDAA statistics that can be implemented in future software tools. We apply the improved methods to conduct spatial randomness analyses on global crater data sets on Mercury, Venus, and the Moon and compare the results to known crater population variations and surface evolution scenarios. On Mercury, we find that the emplacement of smooth plain deposits strongly contributed to a global clustering of craters and that a random distribution of Mercury's basins is not rejected. On Venus, the randomness analyses show that craters are largely randomly distributed across all sizes but where local nonrandom distributions due to lower crater densities in regions of recent volcanic activity may appear. On the Moon, the global clustering of craters is more pronounced than on Mercury due to mare volcanism and the Orientale impact event. Furthermore, a random distribution of lunar basins is not rejected.
Central Pyrenees Mountain Building: Constraints From New LT Thermochronological Data From the Axial Zone
Authors: Waldner Maxime , Bellahsen Nicolas , Mouthereau Frederic , Bernet Matthias , Pik Raphael , Rosenberg Claudio L. , Balvay Melanie
Published: February 2021

Early phases of mountain building are usually poorly constrained although they may provide insights into both the wedge rheology and the role of inheritance. In the central Pyrenean Axial Zone, a main exhumation peak at 35–30 Ma is particularly well constrained but the previous exhumation stages are much less constrained. In this study, we present new low‐temperature thermochronological zircon fission‐track and (U‐Th)/He data and structural observations to constrain the thermal history of the Axial Zone and its shortening sequence during the whole Alpine collision. The dataset collected along the ECORS profile suggests two main collisional cooling phases. An early stage of Alpine shortening (from 70 to 40 Ma) is characterized by low rates of cooling/exhumation in the whole Axial Zone around 5–10°C/Myr and 200 ± 50 m/Myr. During this phase, deformation was distributed within the whole Axial Zone. This result questions the occurrence of a quiescence phase in the Axial Zone. Between 40 and 20 Ma, a more localized second phase with cooling rates around 30°C/Myr and high exhumation rates >800 m/Myr is only recorded in the Maladeta massif. During this second phase, much lower denudation rates are recorded further north and south, thus suggesting rather symmetrical exhumation in the Axial Zone, controlled by underplating of the youngest crustal ramp, the Rialp thrust. This sequence of shortening, from distributed to localized deformation, appears to be characteristic in other collisional wedges as well.
How Do Climate and Catchment Attributes Influence Flood Generating Processes? A Large‐Sample Study for 671 Catchments Across the Contiguous USA
Authors: Stein L. , Clark M. P. , Knoben W. J. M. , Pianosi F. , Woods R. A.
Published: February 2021

Hydrometeorological flood generating processes (excess rain, short rain, long rain, snowmelt, and rain‐on‐snow) underpin our understanding of flood behavior. Knowledge about flood generating processes improves hydrological models, flood frequency analysis, estimation of climate change impact on floods, etc. Yet, not much is known about how climate and catchment attributes influence the spatial distribution of flood generating processes. This study aims to offer a comprehensive and structured approach to close this knowledge gap. We employ a large sample approach (671 catchments across the contiguous United States) and evaluate how catchment attributes and climate attributes influence the distribution of flood processes. We use two complementary approaches: A statistics‐based approach which compares attribute frequency distributions of different flood processes; and a random forest model in combination with an interpretable machine learning approach (accumulated local effects [ALE]). The ALE method has not been used often in hydrology, and it overcomes a significant obstacle in many statistical methods, the confounding effect of correlated catchment attributes. As expected, we find climate attributes (fraction of snow, aridity, precipitation seasonality, and mean precipitation) to be most influential on flood process distribution. However, the influence of catchment attributes varies both with flood generating process and climate type. We also find flood processes can be predicted for ungauged catchments with relatively high accuracy (R2 between 0.45 and 0.9). The implication of these findings is flood processes should be considered for future climate change impact studies, as the effect of changes in climate on flood characteristics varies between flood processes.
Effect of human umbilical cord-derived mesenchymal stem cells on lung damage in severe COVID-19 patients: a randomized, double-blind, placebo-controlled phase 2 trial
Authors: Shi Lei , Huang Hai , Lu Xuechun , Yan Xiaoyan , Jiang Xiaojing , Xu Ruonan , Wang Siyu , Zhang Chao , Yuan Xin , Xu Zhe , Huang Lei , Fu Jun-Liang , Li Yuanyuan , Zhang Yu , Yao Wei-Qi , Liu Tianyi , Song Jinwen , Sun Liangliang , Yang Fan , Zhang Xin , Zhang Bo , Shi Ming , Meng Fanping , Song Yanning , Yu Yongpei , Wen Jiqiu , Li Qi , Mao Qing , Maeurer Markus , Zumla Alimuddin , Yao Chen , Xie Wei-Fen , Wang Fu-Sheng
Published: February 2021

Treatment of severe Coronavirus Disease 2019 (COVID-19) is challenging. We performed a phase 2 trial to assess the efficacy and safety of human umbilical cord-mesenchymal stem cells (UC-MSCs) to treat severe COVID-19 patients with lung damage, based on our phase 1 data. In this randomized, double-blind, and placebo-controlled trial, we recruited 101 severe COVID-19 patients with lung damage. They were randomly assigned at a 2:1 ratio to receive either UC-MSCs (4 × 107 cells per infusion) or placebo on day 0, 3, and 6. The primary endpoint was an altered proportion of whole lung lesion volumes from baseline to day 28. Other imaging outcomes, 6-minute walk test (6-MWT), maximum vital capacity, diffusing capacity, and adverse events were recorded and analyzed. In all, 100 COVID-19 patients were finally received either UC-MSCs (n = 65) or placebo (n = 35). UC-MSCs administration exerted numerical improvement in whole lung lesion volume from baseline to day 28 compared with the placebo (the median difference was −13.31%, 95% CI −29.14%, 2.13%, P = 0.080). UC-MSCs significantly reduced the proportions of solid component lesion volume compared with the placebo (median difference: −15.45%; 95% CI −30.82%, −0.39%; P = 0.043). The 6-MWT showed an increased distance in patients treated with UC-MSCs (difference: 27.00 m; 95% CI 0.00, 57.00; P = 0.057). The incidence of adverse events was similar in the two groups. These results suggest that UC-MSCs treatment is a safe and potentially effective therapeutic approach for COVID-19 patients with lung damage. A phase 3 trial is required to evaluate effects on reducing mortality and preventing long-term pulmonary disability. (Funded by The National Key R&D Program of China and others. ClinicalTrials.gov number, NCT04288102.