bluuebunny/crossref_metadata_2025 huggingface dataset:
Targeting PARP proteins in acute leukemia: DNA damage response inhibition and therapeutic strategies
Authors: Padella Antonella , Ghelli Luserna Di Rorà Andrea , Marconi Giovanni , Ghetti Martina , Martinelli Giovanni , Simonetti Giorgia
Published: January 2022

The members of the Poly(ADP‐ribose) polymerase (PARP) superfamily are involved in several biological processes and, in particular, in the DNA damage response (DDR). The most studied members, PARP1, PARP2 and PARP3, act as sensors of DNA damages, in order to activate different intracellular repair pathways, including single-strand repair, homologous recombination, conventional and alternative non-homologous end joining. This review recapitulates the functional role of PARPs in the DDR pathways, also in relationship with the cell cycle phases, which drives our knowledge of the mechanisms of action of PARP inhibitors (PARPi), encompassing inhibition of single-strand breaks and base excision repair, PARP trapping and sensitization to antileukemia immune responses. Several studies have demonstrated a preclinical activity of the current available PARPi, olaparib, rucaparib, niraparib, veliparib and talazoparib, as single agent and/or in combination with cytotoxic, hypomethylating or targeted drugs in acute leukemia, thus encouraging the development of clinical trials. We here summarize the most recent preclinical and clinical findings and discuss the synthetic lethal interactions of PARPi in acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). Despite the low frequency of genomic alterations of PARP and other DDR-related genes in acute leukemia, selective vulnerabilities have been reported in several disease subgroups, along with a “BRCAness phenotype.” AML carrying the RUNX1-RUNX1T1 or PML-RARA fusion genes or mutations in signaling genes (FLT3-ITD in combination with TET2 or TET2 and DNMT3A deficiency), cohesin complex members (STAG2), TP53 and BCOR as co-occurring lesions, IDH1/2 and ALL cases expressing the TCF3-HLF chimera or TET1 was highly sensitive to PARPi in preclinical studies. These data, along with the warning coming from the observation of cases of therapy-related myeloid malignancies among patients receiving PARPi for solid tumors treatment, indicate that PARPi represents a promising strategy in a personalized medicine setting. The characterization of the clonal and subclonal genetic background and of the DDR functionality is crucial to select acute leukemia patients that will likely benefit of PARPi-based therapeutic regimens.
Medical imaging for plantar heel pain: a systematic review and meta‐analysis
Authors: Drake Chris , Whittaker Glen A. , Kaminski Michelle R. , Chen John , Keenan Anne‐Maree , Rathleff Michael S. , Robinson Philip , Landorf Karl B.
Published: January 2022

Background

Medical imaging can be used to assist with the diagnosis of plantar heel pain. The aim of this study was to synthesise medical imaging features associated with plantar heel pain.

Methods

This systematic review and meta‐analysis conducted searches in MEDLINE, CINAHL, SPORTDiscus, Embase and the Cochrane Library from inception to 12th February 2021. Peer‐reviewed articles of cross‐sectional observational studies written in English that compared medical imaging findings in adult participants with plantar heel pain to control participants without plantar heel pain were included. Study quality and risk of bias was assessed using the National Institutes of Health quality assessment tool for observational cohort and cross‐sectional studies. Sensitivity analyses were conducted where appropriate to account for studies that used unblinded assessors.

Results

Forty‐two studies (2928 participants) were identified and included in analyses. Only 21% of studies were rated ‘good’ on quality assessment. Imaging features associated with plantar heel pain included a thickened plantar fascia (on ultrasound and MRI), abnormalities of the plantar fascia (on ultrasound and MRI), abnormalities of adjacent tissue such as a thickened loaded plantar heel fat pad (on ultrasound), and a plantar calcaneal spur (on x‐ray). In addition, there is some evidence from more than one study that there is increased hyperaemia within the fascia (on power Doppler ultrasound) and abnormalities of bone in the calcaneus (increased uptake on technetium‐99 m bone scan and bone marrow oedema on MRI).

Conclusions

People with plantar heel pain are more likely to have a thickened plantar fascia, abnormal plantar fascia tissue, a thicker loaded plantar heel fat pad, and a plantar calcaneal spur. In addition, there is some evidence of hyperaemia within the plantar fascia and abnormalities of the calcaneus. Whilst these medical imaging features may aid with diagnosis, additional high‐quality studies investigating medical imaging findings for some of these imaging features would be worthwhile to improve the precision of these findings and determine their clinical relevance.
Effects of landscape configuration on the occurrence and abundance of an arboreal marsupial from the Valdivian rainforest
Authors: Fernández Victoria P. , Rodríguez-Gómez Gloria B. , Molina-Marín Dimas A. , Castaño-Villa Gabriel J. , Fontúrbel Francisco E.
Published: January 2022

Background

Habitat fragmentation and degradation processes affect biodiversity by reducing habitat quantity and quality, with differential effects on the resident species. However, their consequences are not always noticeable as some ecological processes affected involve idiosyncratic responses among different animal groups. The Valdivian temperate rainforests of southern Chile are experiencing a rapid fragmentation and degradation process despite being a biodiversity hotspot. Deforestation is one of the main threats to these forests. There inhabits the arboreal marsupialDromiciops gliroides, an iconic species from the Valdivian rainforest, it is the only extant representative of the ancient Microbiotheria order, and it is currently threatened by habitat loss. Here we tested the effects of habitat configuration onD. gliroidesoccurrence and abundance along 12 landscapes of southern Chile with different disturbance levels.

Methods

We estimatedD. gliroidesoccurrence and abundance using camera traps and related those metrics with landscape configuration indices obtained from FRAGSTATS (i.e., forest %, connectivity, patch number, contiguity, and distance to the nearest patch) using Bayesian linear mixed models.

Results

We found thatD. gliroidesoccurrence was not influenced by landscape configuration, while its abundance was positively influenced by forest contiguity.

Conclusions

Although this arboreal marsupial is present in disturbed forests, its restricted movement capabilities and high dependency on the forest three-dimensional structure may affect its long-term persistence. We urge to rethink native forest conservation and management policies to improve habitat connectivity with possible positive consequences for native fauna.
Blunt Traumatic Vertebral Artery Injuries: Incidence, Therapeutic Management, and Outcomes
Authors: Zeineddine Hussein A. , King Nicholas , Lewis Cole T. , Kole Matthew J. , Kitagawa Ryan , Dannenbaum Mark , Chen Peng Roc , Day Arthur L. , Blackburn Spiros
Published: January 2022

BACKGROUND:

Blunt cerebrovascular injury (BCVI) is a term for injuries to the carotid and vertebral arteries (blunt vertebral artery injury [BVAI]) caused by blunt trauma. Computed tomographic angiography is currently the best screening test for BCVI. The subsequent management of any identified vessel injury, however, is not clearly defined.

OBJECTIVE:

To describe one of the largest cohorts of isolated vertebral artery injuries and report the evolution of treated and untreated lesions and clinical outcomes of treatment regimens used to reduce the risk of injury-related stroke.

METHODS:

The list included patients who presented to or were transferred to a level 1 trauma center and found to have an isolated BVAI. Patients were included if imaging was performed within 24 hours of presentation. Data collected included location and grade of injury, timing and type of initial therapy, follow-up imaging, evolution of the disease, and associated strokes.

RESULTS:

A total of 156 patients were included in the analysis. Most patients (135/156) were treated with aspirin alone, 3 with anticoagulation therapy, and 18 did not receive treatment. Three strokes were detected within 24 hours of admission and before treatment initiation. No strokes were detected during the length of the hospitalization for any other patient.

CONCLUSION:

Our data demonstrate that the risk of stroke after cervical vertebral artery injury is low, and aspirin as a prophylactic is efficacious in grade I and IV injuries. There are limited data regarding grade II and grade III injuries. The benefit of early interval imaging follow-up is unclear and warrants investigation.
Contact tracing along with epidemiological and clinical characteristics of Novel corona virus 2019 in prisoners of Camp Jail, Lahore – A prospective case ascertaining study
Authors: Shahid Afshan , Shahid Shaza , Ashraf Muhammad , Saeed Khawwar
Published: January 2022

Background & Objectives: Prisons are reported as hub for communicable disease, as the closed environment, overcrowding, poor hygienic conditions facilitate the disease transmission. This study was conducted to describe contact tracing to identify, educate and manage COVID-19 in camp jail Lahore and to describe clinical and epidemiological features of disease in prisoners.

Methods: After diagnosis of primary case of COVID-19 on 24th March, 2020 in camp jail, 527 suspected cases were identified through contact tracing. The health department-initiated case identification through contact tracing, isolation of confirmed and suspected cases, and quarantine of exposed persons and establishment of 100 bedded hospital in jail for infection prevention and control and treatment. Baseline characteristics of primary case and secondary cases were described along with the secondary attack rate of infection.

Results: Mean age of secondary cases was 36.9(11.5) years with mean stay of 14.9(13.6) months. Two third of the prisoners were from Punjab. 11% were illiterate and almost half were under metric. 527 prisoners were labelled as suspected cases through contact tracing and 59 out of 527 suspected prisoners tested COVID positive through RT-PCR with few reporting mild respiratory symptoms. Fifty five out of 59 tested negatives on day-5 and all have uneventful recovery by day-21. Secondary attack rate was 11%.

Conclusions: In order to prevent COVID-19 outbreaks, proactive containment and comprehensive contact tracing to identify monitor and manage cases and contacts, in incarcerated facilities like prisons is a public health solution to prevent and control large scale epidemic. Active monitoring for infected patients, and implementing timely infection prevention and control measures are mandatory for highly infectious COVID-19 in this vulnerable population.

doi: https://doi.org/10.12669/pjms.38.3.4753

How to cite this:Shahid A, Shahid S, Ashraf M, Saeed K. Contact tracing along with epidemiological and clinical characteristics of Novel corona virus 2019 in prisoners of Camp Jail, Lahore – A prospective case ascertaining study. Pak J Med Sci. 2022;38(3):---------.  doi: https://doi.org/10.12669/pjms.38.3.4753

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Sometimes Finding Nothing is Something: Shrinking the Gap between Emerging Bilingual Learners and English Fluent Students (Case in Point)
Authors: Corrigan Michael W. , Grove Douglas , Andersen Sage , Wong Joseph T. , Hughes Bradley S.
Published: January 2022

For United States of America (USA) and other developed countries, science achievement gaps begin to emerge in elementary and primary school. Such gaps between USA student groups typically are connected to socio-economic status (SES) and issues such as students still learning the English language. Through an experimental design, this National Science Foundation funded study explores how integrating the arts into science, technology, engineering, and mathematics (STEM) curriculum and leading with a more STEAM-first approach (e.g., curriculum which integrates science, technology, engineering, arts, and mathematics) might provide more equitable science learning opportunities for elementary or primary grade level students. More specifically, the project’s research efforts seek to also examine how integrating the arts into science instruction might help emerging bilingual (EB) students who are simultaneously learning the English language and science. Although results provide somewhat conflicting findings of statistical significance with small to moderate effect sizes, outcomes provide initial evidence that leading with STEAM science instruction before STEM efforts can be beneficial to early readers, and for EB students this benefit is magnified. As the title of this study suggest, sometimes finding nothing is something.
Thymol quantitative analysis in medicinal formulation types through employing of nano-technology and antimicrobial activity in some pathogenic bacterial isolates
Authors: BARRAK MOHAMMED HASAN , Majeed Mohauman , MOTAWEQ Zahraa yosif
Published: January 2022

Abstract. Barrak MH, AL-Rufaie MM, Motaweq ZY. 2021. Thymol quantitative analysis in medicinal formulation types through employing nano-technology and antimicrobial activity in some pathogenic bacterial isolates. Nusantara Bioscience 13: 129-137. This study included a method for estimating thymol (THY) in its pure state and in some of its pharmaceutical preparations that were quick, easy, and sensitive, This method is based on nanoparticles that have been modified by oxidation and reduction reactions, In a sodium hydroxide base medium, with polyvinylpyrrolidone as a stabilizer. The thymol  drug works as a reducing agent to dilute the ore mineral salt from silver nitrate (Ag+) to silver nanoparticles; the oxidation-reduction reaction product for thymol has the highest absorption at 410 nm. The calibration curve was calculated, and the following information was determined, indicating that the Beer-Lambert Law was followed within the focus range of 0.25 to 50 parts per million. Sandal's sensitivity was 0.052 ?g/cm2, his molar absorptivity was 2.2883 x 103 L / mol.cm, his standard deviation rate was 0.402%, and his correlation coefficient was 0.9989. The biological effect on a number of Gram-negative and Gram-positive bacteria was studied, and the findings showed that the samples prepared were effective against these bacteria.
Characterization and evaluation of the variability of dragon fruit accessions in Dairi District, North Sumatra Province, Indonesia
Authors: Siregar Luthfi Aziz Mahmud , ANGKAT NINA UNZILA , DAMANIK REVANDY ISKANDAR
Published: January 2022

Abstract. Siregar LAM, Angkat NU, Damanik RI. 2021. Characterization and evaluation of the variability of dragon fruit accessions in Dairi District, North Sumatra Province, Indonesia. Nusantara Bioscience 13: 138-145. Many types of dragon fruits were planted in Dairi District of North Sumatra Province without much information of their importance in economic values. Therefore, this study was carried out to evaluate the variability of the dragon fruit population in this region to assist the local farmers in selecting the best species for planting. This study used a morphological observation method based on dragon fruit descriptor employing a purposive sampling technique. A total of 56 dragon fruit accessions collected from Sidikalang, Sitinjo, and Siempat Nempuhulu Sub-districts were studied and characterized based on the morphological characteristics of stems, flowers, and fruit. The results showed some variations in the stem, flower, and fruit morphology among the studied population. The dragon fruit plant that is widely cultivated by farmers in three sub-districts of Dairi District is a species of Hylocereus polyrhizus. Phenotypic diversity analysis showed seven quantitative characters with broad criteria of eighteen characters observed, namely stem length, pericarpel length, number of lobes, flower shoot length, number of bractea, bractea peak length, and fruit weight. However, phenotypic diversity analysis indicates they are closely related to each other except for accession D17 the red dragon fruit or red pitaya (Hylocereus spp.), and it could be the exotic species for nation-wide planting in Indonesia.
Gas Chromatography-Mass Spectrometry profiling, and evaluation of antioxidant and antibacterial activity of Albizia spp.
Authors: Ghosh Arindam , MAJUMDER SOUMYA , SAHA SUMEDHA , SARKAR SAHADEB , BHATTACHARYA MALAY
Published: January 2022

Abstract. Ghosh A, Majumder S, Saha S, Sarkar S, Bhattacharya M. 2021. Gas Chromatography-Mass Spectrometry profiling, and evaluation of antioxidant and antibacterial activity of Albizia spp. Nusantara Bioscience 13: 177-184. Plant resources have been utilized for human welfare since ancient times. Most of the pharmaceutical industry relies on bioactive molecules from plant resources. This research was carried out to investigate the antioxidant and antibacterial activities of Albizia spp. DPPH assay was conducted to investigate the antioxidant activity and well diffusion test by pour plate method was followed for antibacterial assay. Antioxidant activity confirmed that the leaf extracts with chemical contents having solubility in polar solvents showed high free radical scavenging activity. The free radical scavenging activities of bark extracts were lower than the leaf extracts. Leaf extracts of Albizia procera showed the highest scavenging activity (94.77% or 100.66 µg AE/ ml); followed by Albizia odoratissima (93.52% or 99.23µg AE/ ml); Albizia lebbeck (91.68% or 97.13 µg AE/ ml) and Albizia chinensis (89.91% or 95.11 µg AE/ ml). GC-MS analysis of leaf and bark extracts revealed that 15 compounds had been reported to have antioxidant activities such as beta-amyrin, phytol, squalene, vitamin E and 31 compounds had been reported to have antimicrobial, antibacterial, antifungal, and antiviral activity. The antibacterial activities of leaf and bark extracts of four Albizia species showed that leaf extracts of Albizia spp. showed better antibacterial activity compared to bark samples which were compatible with the results found from GC-MS analysis.
Determining the relevance of HLA/KIR matching/mismatching on kidney and liver transplantation rejection: A meta-analysis
Authors: Batuan Brian , CAJAYON CRISEL JEAN , CASTRO BERLINN AIRIANE , AUSTRIA MIGUEL LUIS , CO DERRICK NIKOLAI , EBREO SOPHIA KRISTINE , CLEMENTE BENJIE , TIONGCO RAPHAEL ENRIQUE
Published: January 2022

Abstract. Batuan B, Cajayon CJ, Castro BA, Austria ML, Co DN, Ebreo SK, Clemente B, Tiongco RE. 2021. Determining the relevance of HLA/KIR matching/mismatching on kidney and liver transplantation rejection: A meta-analysis. Nusantara Bioscience 13: 211-218. The kidney and liver are solid organs commonly transplanted nowadays. However, there are cases wherein graft rejection occurs due to foreign Human Leukocyte Antigen (HLA) proteins. Furthermore, the function of Natural Killer (NK) cells and their receptors in solid organ transplantation is not yet fully elucidated. This study aims to determine the relevance of matching HLA/Killer cell Immunoglobulin-like Receptors (KIR) with kidney and liver transplantation outcomes. Articles were screened according to the inclusion and exclusion criteria provided, which garnered eight definitive studies. Next, data were tabulated using a standardized extraction form. A meta-analysis was conducted to formulate conclusions regarding significance of HLA/KIR matching and mismatching in kidney and liver transplantations. Fixed- and random-effects models were utilized to compute and establish 95% CI and pooled ORs wherein a p-value of less than 0.05 is considered significant. A combination of Chi-square based Q test and I2 statistics were used to identify heterogeneity, which was resolved with a funnel plot. In this meta-analysis, only the HLA-Bw4/KIR3DL1 combination was found significant to lower the risk of allograft rejection (OR=0.73; PA=0.009; PH=0.42). Other combinations which include HLA-C1 and KIR2DL2/3, HLA-C1 and KIR2DS2/3, HLA-C2 and KIR2DL1/DS2, and HLA-Bw4/KIR3DS1 were found to be insignificant; hence, these do not influence the allograft rejections. In conclusion, the role of HLA/KIR combinations on solid organ transplantation rejection is only significant in HLA-Bw4/KIR3DL1 interaction which is correlated with decreased odds of allograft rejection. Factors including KIR allele variations, insufficient data and journals related to the topic, and unestablished association of HLA/KIR in other organ transplantations affected the results of this meta-analysis; thus, these are recommended to be considered in future studies.
Assessment of aflatoxin M1 and B1 in some dairy products with referring to the analytical performances of enzyme-linked immunosorbent assay in comparison to high-performance liquid chromatography
Authors: Esam Raghda Mohamed , Hafez Ragaa Shehata , Khafaga Nagwa Ibrahim Mohamed , Fahim Karima Mogahed , Ahmed Lamiaa Ibrahim
Published: January 2022

Background and Aim: Aflatoxin M1 (AFM1) is a major fungal metabolite found in milk coming from aflatoxin B1 (AFB1) contaminated rations and is subsequently present in milk-based products demonstrating a serious public health hazard. This study aimed to investigate the levels of AFM1 and AFB1 in milk and some dairy products consumed widely by infants and children.

Materials and Methods: This study investigated the incidence of AFM1 in 105 samples of processed cheese, Ras cheese, and raw milk (35 of each) retailed in the Egyptian markets. The degree of sensitivity and accuracy was evaluated using the enzyme-linked immunosorbent assay (ELISA) method followed by the estimation of the positive samples using the high-performance liquid chromatography (HPLC) with fluorescence detection. Mold count was determined in the examined samples by investigating AFB1 content using HPLC.

Results: AFM1 was found in all investigated Ras cheese, raw milk, and 82.86% of the processed cheese samples with mean values of 51.05±6.19, 40.27±3.996, and 10.77±1.39 ng/kg, respectively. Moreover, there was statistically no significant difference between AFM1 levels in the core and crust parts of the tested Ras cheese. AFM1 contaminated Ras cheese and raw milk samples were 48.57% and 25.71%, which exceeded the European and Egyptian tolerance levels. Results showed an acceptable correlation between ELISA and HPLC methods with no significant difference (p>0.05). Alternatively, none of the examined samples proved to be contaminated with AFB1 despite the presence of mold with mean counts of 3.79±3.29, 4.39±4.34, and 4.84±4.29 log CFU/g in the examined processed cheese, Ras cheese, and raw milk samples, respectively.

Conclusion: Therefore, it is urgent to regularly inspect the contamination of animal feeds with AFB1 and apply special measures and novel techniques to protect the feed and food from public health hazards.
ASSESSMENT OF LIFE IN RURAL AREA FROM THE PERSPECTIVE OF A GENDER APPROACH
Authors: Salmorbekova Rita B. , Imanbaev Samat K. , Karabaeva Indira
Published: January 2022

The work analyzes the social problems of modern life in rural areas of the Kyrgyz Republic. With the help of a sociological survey, the level and quality of life of the rural population have been analyzed. The study covered 14 villages and conducted 18 focus groups. The research reflects social problems in the context of a gender approach and reveals main factors influencing the efficiency of socio-economic development of rural areas. In the course of the research, it was found that many villages were abandoned and slightly lagged in their development. The respondents assessed a good quality of life as good health, earning money in the village, drinking water supply, peace, and tranquility in society, family, etc. Respondents associated low quality of life with a lack of stability in the country; migration and unemployment; financial dependence; misunderstanding in the family, divorce; moral impoverishment (loss of harmony, respect). In general, the quality of life has improved over the past five years: 31.9% of men and women reported about «significant improvement», and 41.7% – about «improvement», regardless of age, 26.4% noted that it remained the same, none of the respondents noted that their living conditions have deteriorated over the past five years. The authors conclude that rural residents have learned the laws of market relations and changed their outlook on life, without demanding anything from the state. The rise in pensions, benefits, teacher salaries, and the rise in livestock prices, especially in recent years, have contributed to an improvement in the quality of life. With the increase in money, the consumption of household goods has increased.
SOCIO-ECONOMIC CONDITIONS OF HUMAN CAPITAL FUNCTIONING IN THE REGIONS OF RUSSIA
Authors: Cherepanova Maria I. , Safronova Elena Yu. , Maximov Maxim B. , Ilyushnikov Konstantin K.
Published: January 2022

The relevance of the study is due to the fact that socio-economic conditions determine the effectiveness of human capital, and are also an indicator of its implementation and reproduction, reflecting regional specifics in the conditions of significant heterochrony of modern Russian society. The purpose of the article is to analyze the regional socio-economic mechanisms of the crisis functioning of human capital, the problems of institutionalization of management of this phenomenon. The factors and conditions of socio-economic conditionality of the processes of education and labor of the population of six Russian territories are analyzed. The approach of complex analysis of the research data is used, taking into account demographic, socio-economic indicators. The results of empirical verification of the effectiveness of human capital are presented. Its regional trends are described. Conclusions are drawn that the results of a comprehensive study of economic, institutional, social, behavioral peculiarities the vital activity of the population allows not only to identify current trends, but also to suggest ways to optimize them.
Social Support and Decreased Likelihood of Alcohol Misuse among Persons with Dementia
Authors: McDaniel Justin , Hascup Kevin , Hascup Erin , Albright David , Wallace Juliane
Published: January 2022

Objective: In this study, our aim was to improve understanding of the role of social support – which is the subject of a Healthy People 2030 goal – in the likelihood of adverse health behaviors among persons with subjective cognitive decline (SCD). Methods: We used a multinomial logistic regression model to examine the association between social support and alcohol misuse in a sample of individuals with SCD (N = 474) from the 2015-2016 Behavioral Risk Factor Surveillance System (BRFSS). Results: Overall, 9.4% (95% CI = 6.7, 13.2) of the individuals with SCD reported “never” receiving needed social/emotional support and 7.0% (95% CI = 4.6, 10.5) of individuals with SCD reported “never” receiving help with activities of daily living. Results showed that 4.4% (95% CI = 2.7, 7.5) of participants reported heavy alcohol consumption, binge consumption of alcohol, or both. Lower scores on a 2-item composite measure of social support were associated with increased risk of binge consumption of alcohol with co-engagement in heavy alcohol use throughout the week (RRR = 1.92, p = .04) in adjusted analyses. Conclusions: We showed that low social support may be associated with an adverse health behavior among persons with SCD.
Caracterización del patrón proteico y perfil antigénico de larvas L3 de anisákidos de importancia médica aisladas de peces comerciales de la costa peruana
Authors: Martínez-Rojas Rosa , Mondragón-Martínez Aarón , Pulido-Murillo Eduardo A. , Tantaleán-Vidaurre Manuel
Published: January 2022

Introducción. La anisakidosis es una zoonosis causada por la ingestión accidental de larvas (L3) de anisákidos. Objetivo. Caracterizar el patrón proteico y perfil antigénico de la L3 de Anisakis simplex s.l. (tipo I), A. physeteris s.l. (tipo II) y Contracaecum osculatum s.l. aisladas de peces comerciales. Métodos. Se realizó una corrida electroforética en SDSPAGE de los antígenos somáticos. Se inmunizó conejos experimentalmente y se evaluó por EITB. Resultados. El patrón proteico de Anisakis tipo I mostró 12 bandas, 18 Anisakis tipo II y C. osculatum 13, con las bandas 10 y 35 kDa específicas para Anisakis tipo II, 28 y 77 para C. osculatum no presentes en Anisakis tipo I. Conclusión. se determinó bandas inmunogénicas específicas para Anisakis tipo I con las proteínas de peso molecular 11, 14, 25 y 40 kDa, para el tipo II de 9, 10, 12, 35 y 41 kDa, y C. osculatum 13, 15, 17, 30 y 47 kDa.
Efecto de un programa de ejercicios en síntomas músculo esqueléticos en docentes de primaria
Authors: Manrique-Collantes Rosmery V.
Published: January 2022

Introducción. Los docentes de nivel primario están expuestos a riesgos físicos que pueden controlar mediante un programa de ejercicios, el cual busca promover mejoras para su salud de manera oportuna. Objetivos. Determinar el efecto de un programa de ejercicios en los síntomas músculo esqueléticos en docentes de nivel primario. Métodos. Se realizó un estudio experimental, donde se aplicó el cuestionario de Cornell. Resultados. Los docentes presentaron una mediana de 52 años de edad. Al inicio se encontró que los síntomas músculo esqueléticos más frecuentes de todos los docentes se encontraban en cuello (50,8%), espalda baja (41,5%), pie izquierdo (35,4%) y pie derecho (33,9%); en la comparación final entre los grupos, se observó que la intensidad obtuvo diferencias significativas de valor de p<0,01 para cuello, hombro derecho/izquierdo, espalda alta, espalda baja, rodilla derecha/izquierda. El grupo intervención obtuvo 25% a más para las zonas de cuello, espalda baja, hombro derecho/izquierdo y pie derecho; mientras que en el grupo control, el 18,2% empeorarían en la zona de la espalda baja. Conclusiones. El programa de ejercicios disminuyó significativamente los síntomas musculo esqueléticos de los docentes del grupo intervención, mientras que en el grupo control se mantuvieron similares o aumentaron.
Avances en la investigación de enfermedades crónicas no transmisibles en el Perú
Authors: Del Castillo-Fernández Darwin , Brañez-Condorena Ana , Villacorta-Landeo Pamela , Saavedra-Garcia Lorena , Bernabé-Ortiz Antonio , Miranda Jaime
Published: January 2022

Las enfermedades no transmisibles (ENT) son causa importante de carga de enfermedad en el Perú así como en otros países en desarrollo. Las respuestas para el control de las ENT requieren de investigación multidisciplinaria, tanto a nivel local como internacional. Desde hace más de 10 años, CRONICAS: Centro de Excelencia en Enfermedades Crónicas, de la Universidad Peruana Cayetano Heredia, realiza investigación en el campo de las ENT en el Perú. En el presente artículo se describen algunos estudios realizados, incluyendo los estudios epidemiológicos PERU MIGRANT, y la cohorte CRONICAS. También se presentan resultados de revisiones sistemáticas y resultados de intervenciones frente a las ENT. A través de estos estudios llevados a cabo por el centro CRONICAS se señalan potenciales áreas para afrontar las ENT en países en desarrollo.
Dimensión ambiental en la formación de profesionales de la salud: concepciones de los docentes de una universidad pública
Authors: Arroyo Ruth , Espinoza John , Lujan Anita
Published: January 2022

Objetivo. Analizar las concepciones de docentes sobre la integración de la dimensión ambiental en la formación de profesionales de salud en una universidad pública. Métodos. Estudio cualitativo, donde participaron 13 docentes seleccionados por un muestreo socioestructural. Se aplicó una entrevista semiestructurada y la técnica de análisis de contenido utilizando ATLAS.ti. Resultados. Los docentes reconocieron limitaciones para incorporar la dimensión ambiental en profesionales de la salud, pero se concentran en los cambios que se necesitarían para su integración a nivel macro y microcurricular. El análisis evidencia la vinculación entre los cambios necesarios con acciones de sensibilización y socialización, gestión política y administrativa, y propuestas de mejora de infraestructura. Conclusión. Los docentes, a pesar de las limitaciones, tienen concepciones proactivas hacia el cambio, lo que favorecería su participación en procesos de reforma curricular hacia una formación orientada al desarrollo sostenible.
Enfermedad de Rosai-Dorfman primaria ósea
Authors: Padilla Flores Juan Roberto , Victorio Avila Cesar Antonio , Latorre Zúñiga Alan Jesús , Romero Espinoza Edgar Jesus , Pineda Borja Vanessa Irene
Published: January 2022

La enfermedad de Rosai-Dorfman es una patología poco común que suele presentarse con adenopatías cervicales indoloras. El compromiso óseo como presentación extraganglionar es aún menos frecuente. Se presenta el caso de una mujer de 38 años con 3 meses de dolor y limitación funcional en miembro inferior derecho. La radiografía simple y tomografía computarizada mostraron la presencia de una lesión ósea lítica en la metáfisis y epífisis distal del fémur derecho. Finalmente, el estudio histopatológico e inmunohistoquímico de la lesión determinó que se trataba de un caso de enfermedad de Rosai-Dorfman primaria ósea.
Hidatidosis renal: a propósito del segundo caso en Perú
Authors: Vizcarra Vizcarra Cristhian Adolfo
Published: January 2022

He leído con mucho interés y entusiasmo el artículo recientemente publicado por Guitton y colaboradores1, que muestra un nuevo reporte de caso sobre hidatidosis renal, una entidad bastante infrecuente. Previamente, nosotros reportamos el caso de un paciente de 67 años, con clínica de dolor lumbar, disuria, polaquiuria y tenesmo vesical, en quien se sospechó de neoplasia maligna requiriendo nefrectomía radical izquierda y se diagnosticó hidatidosis renal asociada a glomeruloesclerosis focal y segmentaria, recibiendo tratamiento con albendazol2, siendo el primer caso con localización renal reportado en nuestro país.

A raíz de esto, decidí realizar una búsqueda bibliográfica de la literatura disponible en PubMed, entre los años 2019 a 2021, usando los términos «renal hydatid cyst» y «kidney hydatidosis», encontrando varios casos reporte que detallo en la Tabla 1. Llama la atención que no se encontró ningún caso reportado en Sudamérica. La edad media fue 36.5 ± 18.583,y. Del total de casos encontrados, el 57% corresponde a mujeres y sólo se encontró un caso pediátrico. En su gran mayoría (8/14) se localizaron en el lado derecho y sólo el 28.57% tuvieron localización hepática concomitante, aunque se reportó un sólo caso de ubicación en riñón, hígado y pulmón. El dolor abdominal estuvo presente en el 100% de los casos, aunque en diferentes zonas anatómicas, y sólo se encontró un caso con hidatiduria; siendo, en su gran mayoría el tratamiento quirúrgico y con albendazol.

En conclusión, la hidatidosis es una zoonosis causada por Echinococcus granulosus, con afectación predominante de hígado y pulmón y rara vez, localización renal. A pesar de la alta incidencia de hidatidosis en Sudámerica, no encontramos ningún caso reportado con compromiso renal en esta parte del continente. El síntoma más importante es el dolor abdominal y debe sospecharse ante un paciente con imagen quística renal.
Biopesticide Registration: Difficulties and Challenges Within the Industry
Authors: Ansari Minshad
Published: January 2022

Biopesticides are becoming more and more a major part of our daily lives, but they are not necessarily getting easier or cheaper to register. In fact, most people do not realize that it takes an average of 5-10 years and £3-5 million in the EU (European Union) compared to $300-400k
registration and regulatory fees in the US. So, how hard is it to obtain biopesticide registration for your new product? SMEs are struggling to register biocontrol products due to an expensive and overly complex regulatory process in the EU. This guide offers the necessary insights for bringing
products to market, navigating the regulatory system with minimal fuss and expense.
The Linkages Between Democracy, Terrorism and Foreign Direct Investments in Developed and Developing Countries
Authors: ÇELİK Necmettin , BAYRAK Rıza
Published: January 2022

In this study, the linkages between political dynamics and foreign direct investment inwards to 118 developed and developing countries over the 2002-2017 period were analysed by the System GMM Panel Model to avoid the potential endogeneity problem. Findings indicate that the most vital positive determinant of FDI inwards is trade liberalization or trade openness. Also, there is no statistically significant relationship between countries’ democratization and freedom level and FDI inwards. However, terrorism hinders FDI directly, especially in developed countries. Therefore, the decision of foreign investors might mainly depend on economic dynamics, which are related to them and host countries rather than politics.
The Mediating Role of Impulsive Buying in The Relationship Between Fear of COVID-19 and Compulsive Buying: A Research on Consumers in Turkey
Authors: KÜÇÜKKAMBAK Selçuk Efe , SÜLER Melek
Published: January 2022

This study aims to reveal the mediating effect of impulsive buying behaviour in the relationship between fear of COVID-19 and compulsive buying behaviour. In this direction, the data collected from 721 participants by online survey method were analysed using various statistical methods. According to the findings, the fear of COVID-19 experienced by individuals affects compulsive and impulsive buying behaviours. In addition, the mediator effect of impulsive buying behaviour was found in the impact of fear of COVID-19 on compulsive buying behaviour. It is expected that the research results will contribute to the literature in terms of revealing the effect of negative emotional states on consumer purchasing behaviour.
Repurchasing an Environmental Related Crisis Experienced Automobile Brand: An Examination in the Context of Environmental Consciousness, Brand Trust, Brand Affect, and Resistance to Negative Information
Authors: GÜLTEKİN Beyza , KİLİC S. Ihsan
Published: January 2022

This study explores the direct effects of brand trust and environmental consciousness on the intention to repurchase a brand; tests the indirect impacts of brand affect and resistance to negative information in the effect of brand trust on intention to repurchase. The data collected from 110 current users of a particular brand of an automotive company that has recently faced an environmental crisis. SEM and process analysis are used to test the hypotheses. Brand trust positively affects repurchase intention, whereas environmental consciousness does not. Brand affect and resistance to negative information are mediators. For an environmental crisis experienced brand; this study clarifies the significance of brand related concepts (e.g., brand trust, brand affect) and resistance to negative information instead of environmental consciousness in an emerging market, Turkey.
Gelişmiş ve Gelişmekte Olan Ülkelerde Kaynaklarına Göre Vergi Türleri ve Ekonomik Büyüme İlişkisi
Authors: AYDOĞDU BAĞCI Semra , SEVER Erşan
Published: January 2022

Bu çalışmanın amacı; kaynaklarına göre vergi türleri olan gelir, servet ve harcamalar üzerinden alınan vergilerin ekonomik büyümeye olan etkisini araştırmaktır. 28 gelişmiş ve 34 gelişmekte olan ülkenin alındığı bu çalışma 1990-2018 dönemini kapsamaktadır. Analizde, bağımlı değişken olarak kişi başı Reel Gayri Safi Yurtiçi Hasıla (RGSYH) alınmıştır. Hem gelişmiş hem de gelişmekte olan ülkeler için iki model kurulmuş olup; birinci modelde temel vergiler, ikinci modelde ise bu vergilerin altında yer alan vergiler olarak alınmıştır. Vergi gelirleri ile ilgili verilere, OECD resmi internet sitesinden erişilmiştir. Durağan ve durağan olmayan değişkenlerin birlikte analiz edilmesine imkân verdiği için Panel-ARDL yöntemi kullanılmıştır.
Privatdozent Shkarin. Basedow's disease at an early age. Medical newspaper. No. 2. 1908
Authors: Zhilin Ivan N.
Published: January 2022

Based on the relevant literature and personal experience, the author comes to the following conclusions about the features of the course of Basedow's disease in childhood: the disease proceeds faster than in adults; pulse arrhythmia is extremely rare; goiter - insignificant; exophthalmusweak; the symptoms of Graefe, Mbius and Stellwag are rare; children are growing rapidly.
Rosenbakh P. Ya. Evaluation of the doctrine of manic-depressive psychosis. "Russian doctor". No. 2. 1908
Authors: Zhilin Ivan N.
Published: January 2022

This article contains a critique of some features of Kraepelin's grouping of psychoses, to whose views the author is generally opposed. The author, for example, proposes to significantly narrow the scope of the forms united in "dementia paracex", leaving for the latter diseases in which "the case begins with extremely variable phenomena - oppression or excitement, fragmentary delusions with deceptions of the senses and mild confusion, and already after a few months from the onset of the disease, a very noticeable dementia is established, firmly seizing the patient.
L. V. Blumenau. Human brain. Anatomical and physiological introduction to the clinic of nervous and mental illnesses. Issue I. St. Petersburg. 1907
Authors: Markelov G. I.
Published: January 2022

The first edition of this manual consists of three chapters. The first of them is devoted to the tissue elements of the brain. Here, for 25 pages, the history and current state of the study of neurons are outlined, the internal structure of nerve cells is described, and in conclusion a brief outline of the embryological development of tissue elements is presented.
Chronicle and mix. Volume XV, № 2 (1908)
Authors: Baklushinskiy Ivan D.
Published: January 2022

The Society of Psychiatrists in St. Petersburg at a meeting on April 5, after listening to the word of the chairman Acad. V. M. Bekhtereva, dedicated to the memory of the Chairman of the Medical Council L. F. Ragozin, honored the memory of the deceased by standing up and unanimously decided to send a telegram to the widow of L. F. Ragozin expressing feelings of lively condolences about the untimely heavy loss that all Russian psychiatry suffered with her and the medical family in general. (Review. Psych.)
H. frangais et R. lacques. Anatomical and clinical study of the case of softening in the area of the medulla oblongata and pons Varolii. "Revue neurologique" 1908. № 11
Authors: Osokin Nikolay E.
Published: January 2022

A case is described where a patient has 44 hp. presenting some tabic symptoms, suddenly developed severe phenomena in the form of dizziness, balance disorder with a tendency to fall to the left, left-sided dAvellis syndromecharacterized by a paretic state of the palatine curtain and larynx on one side, right-sided syringo-myelitic type anesthesia; myosis, narrowing of the palpebral fissure of the left eye, thermal asymmetry. The patient died two months later. Autopsy revealed three foci of softening throughout the medulla oblongata and pons.
Dr. A. Gregor und dr. B. Hansel. Materials for the study of the disorder of external volitional manifestations. Experience of ergography in catatonia and melancholic mood
Authors: Sholomovich A. S.
Published: January 2022

The authors studied the qualitative difference between ergographic curves in different patients with these forms, from the obtained curves given in the article, the authors conclude: melancholic curves give a short and relatively low rise, descending steeply downwards and stretching for quite a long time in this position; the curves differ from the curves of normal people by their peculiarity of type: while in a healthy person fatigue shortens the curve, in a melancholic the increase in fatigue generally shortens it relatively little. The article is supplied with 12 curves and substantiated in great detail.
Prof. Chizh. The significance of political life in the etiology of mental illness. Review of psychiatry, and experimental psychology. No. I-3. 1908
Authors: Zhilin I.
Published: January 2022

The author does not see, contrary to generally accepted views, the relationship between political events and cases of insanity supposedly on this basis. In his opinion, the higher the civilization, the fuller, therefore, freedom, the more the frail and wretched survive, including the nervously and mentally ill. And vice versa, the restriction of this freedom, the cruel suppression of attempts to win it, does not lead to an increase in the number of mentally ill people: perhaps predisposed persons fall ill, and then by chance, outside the direct influence of events, giving those reasons for doubtful conclusions about a causal relationship between illness and historical moment; the leaders of the movement, on the other hand, usually have the most gifted and steadfast spiritual organization, without prejudice to the moral upheavals of the revolutionary period.
IV. International thalassotherapy meeting in Abbazia in 1908
Authors: Pel Alexander V.
Published: January 2022

In September 1908 (from 15/28 to 17/30 Sept.) in the city of Abbation (Austria) the IV International Congress on Thalassotherapy will be held.

The previous 3rd international congress on thalassotherapy (in Biarritz in 1907) marked the following issues for discussion at this year's congress:
Prophetic Dreams
Authors: Popov Mikhail N.
Published: January 2022

Great are the advances that modern man is making in all branches of theoretical and practical knowledge! Every decade, almost every year brings us new discoveries; new horizons unfold before us, the existence of which we previously did not suspect; the mighty forces of nature obediently submit to you, becoming an obedient tool in our weak hands. And even the most ardent fantasy is now unable to imagine the limit to which we will reach.
The Impact of Global Economic Policy Uncertainty and Volatility on Stock Markets: Evidence from Islamic Countries
Authors: Adam Norashikin , Sidek Noor Zahirah Mohd , Sharif Arshian
Published: January 2022

This study investigates the impact of uncertainty and volatility on ten Islamic stock returns using monthly data for from 2011:M5 to 2021:M5. We rely on the continuous wavelet transform and wavelet coherence ratios, which allows decomposition of time series across time scales to investigate the causal relationship between stock market returns, economic policy uncertainty and volatility. Our results provide some interesting insights. First, economic policy uncertainty, in general, has a negative effect on the majority of Islamic stock returns, except for the Dow Jones Islamic Market (DJIM). Second, volatility has a significant positive impact on most of the Islamic stock returns in various countries. Third, both economic policy uncertainty and volatility have a greater impact on the Islamic stock returns post-COVID-19 outbreak. These results should assist investors to re-evaluate their portfolios to fully maximize the potentials of these Islamic stock markets. Policymakers could use these results to design policies to reduce economic policy uncertainty as well as to cushion the impact of externally generated uncertainties.