bluuebunny/crossref_metadata_2025 huggingface dataset:
Positive clinical outcomes following therapy with programmed cell death protein 1/programmed cell death ligand 1 inhibitors in neuroendocrine carcinoma of the cervix
Authors: Liu Rongyu , He Xinlin , Li Zhengyu
Published: November 2022

Neuroendocrine carcinoma of the cervix (NECC) is a highly aggressive and rare gynecological malignancy with a poor prognosis. Despite aggressive local and systemic treatments, there are high rates of locoregional recurrence and distant metastases. Therefore, more potent treatments are required to manage NECC. In recent years, emerging immune checkpoint inhibitors, such as programmed cell death protein 1 (PD-1)/programmed cell death ligand 1 (PD-L1) inhibitors, have been used in treating various solid tumors and provide a new direction for immune-targeted therapy for NECC. In this review, we summarize the biomarkers useful for the evaluation of the therapy with PD-1/PD-L1 inhibitors in patients with NECC and the clinical applications and prospects of monotherapy with PD-1/PD-L1 inhibitors and combinations with other therapies in patients with NECC. In some individual case reports, therapeutic strategies with PD-1/PD-L1 inhibitors showed good efficacy. Further studies are needed to confirm the possibility of using PD-1/PD-L1 inhibitors as a standard treatment strategy in NECC.
Proteomics analysis reveals novel insights into the mechanism of hepatotoxicity induced by Tripterygium wilfordii multiglycoside in mice
Authors: Miao Yingying , Zhang Qin , Yuan Zihang , Wang Jie , Xu Yunxia , Chai Yuanyuan , Du Min , Yu Qinwei , Zhang Luyong , Jiang Zhenzhou
Published: November 2022

Tripterygium wilfordiimultiglycoside (GTW), extracted and purified from the peeled roots ofT. wilfordiiHook.f. (TwHF), is a well-known traditional Chinese medicine and applied to various autoimmune diseases clinically. However, it has been reported to cause severe liver injury. At present, the mechanism underlying GTW-induced hepatotoxicity remain poorly defined. Here, we evaluated the effects of GTW on mouse liver and elucidated the associated mechanismsvialabel-free proteomics combined with bioinformatics analysis. Male C57BL/6J mice were randomly divided into normal group, a low-dose GTW (70 mg/kg) group and a high-dose GTW (140 mg/kg) group. After 1-week administration, GTW dose-dependently induced hepatotoxicity. Further analysis showed that GTW could act on the intestinal immune network for IgA production pathway, which plays an important role in maintaining intestinal homeostasis and influences the crosstalk between gut and liver. Western blots confirmed that GTW could decrease pIgR protein expression in the liver and ileum, and, as a result, the secretion of IgA into gut lumen was reduced. Further validation showed that intestinal barrier integrity was impaired in GTW-treated mice, promoting bacteria transferring to the liver and triggering proinflammatory response. Our study demonstrated that gut-liver axis may play a vital part in the progression of GTW-induced hepatotoxicity, which provides guidance for basic research and clinical application of GTW.
Exploring the potential mechanism of Fritiliariae Irrhosae Bulbus on ischemic stroke based on network pharmacology and experimental validation
Authors: Zijie Wang , Anan Jiang , Hongmei Xiao , Xiaofan Yuan , Shaoru Zhang , Xinyue Qin
Published: November 2022

Objective: To study the potential targets and molecular mechanisms of Fritiliariae Irrhosae Bulbus (FIB) in the treatment of ischemic strokes based on a network pharmacology strategy, with a combination of molecular docking and animal experiments.

Methods: The active components and targets of FIB were screened by TCMSP database and TCMIP database, and the related targets of ischemic strokes were screened by GeneCards, OMIM, CTD, and DrugBank, then the intersection targets of the two were taken. The protein interaction network was constructed by STRING, the PPI network diagram was drawn by using Cytoscape software, and the key targets of FIB treatment of ischemic strokes were analyzed by MCODE. The DAVID database was used for GO and KEGG enrichment analysis, and the potential pathway of FIB against ischemic strokes was obtained. Molecular docking was performed by using AutoDock Tools 1.5.6 software. Finally, a mouse model of ischemic stroke was established, and the results of network pharmacology were verified by in vivo experiments. Realtime Polymerase Chain Reaction was used to detect the expression levels of relevant mRNAs in the mouse brain tissue. Western blot was used to detect the expression levels of related proteins in the mouse brain tissue.

Results: 13 kinds of active components of FIB were screened, 31 targets were found in the intersection of FIB and ischemic strokes, 10 key targets were obtained by MCODE analysis, 236 biological processes were involved in GO enrichment analysis, and key targets of KEGG enrichment analysis were mainly concentrated in Neuroactive light receptor interaction, Calcium signaling pathway, Cholinergic synapse, Hepatitis B, Apoptosis—multiple specifications, Pathways in cancer and other significantly related pathways. There was good binding activity between the screened main active components and target proteins when molecular docking was performed. Animal experiments showed that the infarct volume of brain tissue in the FIB treatment group was considerably reduced. RT-qPCR and the results of Western Blot showed that FIB could inhibit the expression of active-Caspase3, HSP90AA1, phosphorylated C-JUN, and COX2.

Conclusion: Based on network pharmacology, the effect of FIB in the treatment of ischemic strokes was discussed through the multi-component-multi-target-multi-pathway. The therapeutic effect and potential mechanisms of FIB on ischemic strokes were preliminarily explored, which provided a ground work for further researches on the pharmacodynamic material basis, mechanism of action and clinical application.
Suppressing circ_0008494 inhibits HSCs activation by regulating the miR-185-3p/Col1a1 axis
Authors: Li Binbin , Zhou Jiaming , Luo Yuanyuan , Tao Kegong , Zhang Lifen , Zhao Ying , Lin Yong , Zeng Xin , Yu Hongyu
Published: November 2022

Background: Hepatic fibrosis (HF) is characterized by activation of hepatic stellate cells (HSCs) and extensive deposition of extracellular matrix components, especially collagens. However, effective antifibrotic therapies are still lacking. Recently, circular RNAs (circRNAs) have been identified as novel regulators of HF.

Methods: circRNAs profile was screened by RNA sequencing and the location of circ_0008494 was confirmed by fluorescence in situ hybridization assay in human HF tissues. Bioinformatics analysis was used for result prediction and dual-luciferase reporter, together with AGO-RIP and biotin-coupled miRNA capture assays, were used to determine miR-185-3p/collagen type I alpha 1 chain (Col1a1) as the target of circ_0008494. A stable circ_0008494-interfering human HSCs cell line was constructed and used to determine the regulatory mechanism of circ_0008494/miR-185-3p/Col1a1 axis.

Results: circ_0008494 was abundantly and significantly over-expressed in human HF tissues and located at the cytoplasm of HSCs. Together, dual-luciferase reporter, AGO-RIP and biotin-coupled miRNA capture assays confirmed that circ_0008494 acted as a sponge of miR-185-3p. Cell functional experiments and rescue assays demonstrated suppressing circ_0008494 could inhibit activation, proliferation, migration of HSCs and promote their apoptosis through miR-185-3p. In particular, the HF indicator, Col1a1, was validated as the direct target of miR-185-3p and the suppression of circ_0008494 inhibited the expression of Col1a1 by releasing miR-185-3p.

Conclusion: Knocking down circ_0008494 inhibited HSCs activation through the miR-185-3p/Col1a1 axis. circ_0008494 could be a promising treatment target for HF.
Emerging pharmaceutical therapeutics and delivery technologies for osteoarthritis therapy
Authors: Shentu Cheng-Yu , Yan Ge , Xu Dong-Chen , Chen Yong , Peng Li-Hua
Published: November 2022

Osteoarthritis (OA) is one of the most common joint degenerative diseases in the world. At present, the management of OA depends on the lifestyle modification and joint replacement surgery, with the lifespan of prosthesis quite limited yet. Effective drug treatment of OA is essential. However, the current drugs, such as the non-steroidal anti-inflammatory drugs and acetaminophen, as well as glucosamine, chondroitin sulfate, hyaluronic acid, are accompanied by obvious side effects, with the therapeutic efficacy to be enhanced. Recently, novel reagents such as IL-1 antagonists and nerve growth factor inhibitors have entered clinical trials. Moreover, increasing evidence demonstrated that active ingredients of natural plants have great potential for treating OA. Meanwhile, the use of novel drug delivery strategies may overcome the shortcomings of conventional preparations and enhance the bioavailability of drugs, as well as decrease the side effects significantly. This review therefore summarizes the pathological mechanisms, management strategies, and research progress in the drug molecules including the newly identified active ingredient derived from medicinal plants for OA therapy, with the drug delivery technologies also summarized, with the expectation to provide the summary and outlook for developing the next generation of drugs and preparations for OA therapy.
C1QBP regulates mitochondrial plasticity to impact tumor progression and antitumor immune response
Authors: Wang Qiping , Chai Dafei , Sobhani Navid , Sun Nan , Neeli Praveen , Zheng Junnian , Tian Hui
Published: November 2022

Mitochondrial plasticity including mitochondrial dynamics, metabolic flexibility, and mitochondrial quality control, impact tumor cells’ progression and determine immune cells’ fate. Complement C1q binding protein (C1QBP) plays an indispensable role through regulating mitochondrial morphology, metabolism, and autophagy. C1QBP promotes mitochondrial plasticity to impact tumor metastasis and their therapeutic response. At the same time, C1QBP is involved in regulating immune cells’ maturation, differentiation, and effector function through the enhancement of mitochondrial function. In this regard, manipulation of C1QBP has been shown to adjust the competitive balance between tumor cells and immune cells. In the course of evolution, mitochondrial plasticity has endowed numerous advantages against the relentless microenvironment of tumors. In this current review, we summarize the current knowledge of the mechanism of C1QBP regulation of cancer and immunity. We explain this process in vision of potentially new anticancer therapies.
Regulatory roles of Bxy-laf-1 in reproductive behaviour of Bursaphelenchus xylophilus
Authors: Sun Shimiao , Wang Jinghan , Liu Wenyi , Chen Jing , Zhou Lifeng , Wu Choufei , Yu Hongshi , Hu Jiafu
Published: November 2022

Bursaphelenchus xylophilu is a worldwide quarantine nematode, causing huge economic losses and ecological disasters in many countries. The sex ratio of B. xylophilus plays an important role in the nematode infestation. The laf-1-related genes are highly conserved in animals, playing crucial roles in sex determination. Therefore, we investigated the expression pattern and biological function of its orthologue, Bxy-laf-1 in B. xylophilus. Bxy-laf-1 has two typical conserved DNA-binding domains, DEAD and Helicase C. The real-time quantitative PCR data revealed that Bxy-laf-1 expression was required throughout the entire life of B. xylophilus, with the maximum expression in the J2 stage and the lowest expression in the adult stage. mRNA in situ hybridization showed that Bxy-laf-1 is mainly located in the cephalopharynx and reproductive organs of B. xylophilus. RNA interference (RNAi) indicated that the head swing frequency was dramatically decreased. The RNA interference results displayed that a significant reduction in motility was observed in the hatched larvae. The female to male sex ratio was also decreased in the F0 and F1 generations, but recovered in the F2 generation. The tail of female adults with eggs in the belly appeared deformities. This phenomenon appeared in the F0 and F1 generations, but recovered in the F2 generation. Bxy-laf-1 is a typical sex-determination gene with distinct expression patterns in males and females. As demonstrated in other species, the sex ratio was altered after knocking down Bxy-laf-1 expression. The results of this study contribute to our understanding of the molecular processes of Bxy-laf-1 in B. xylophilus, which may provide clues about how to control pine wilt disease by inhibiting ontogenic growth and reducing nematode fertility.
Knockdown of Ift88 in fibroblasts causes extracellular matrix remodeling and decreases conduction velocity in cardiomyocyte monolayers
Authors: Ernault Auriane C. , Kawasaki Makiri , Fabrizi Benedetta , Montañés-Agudo Pablo , Amersfoorth Shirley C. M. , Al-Shama Rushd F. M. , Coronel Ruben , De Groot Joris R.
Published: November 2022

Background: Atrial fibrosis plays an important role in the development and persistence of atrial fibrillation by promoting reentry. Primary cilia have been identified as a regulator of fibroblasts (FB) activation and extracellular matrix (ECM) deposition. We hypothesized that selective reduction of primary cilia causes increased fibrosis and facilitates reentry.

Aim: The aim of this study was to disrupt the formation of primary cilia in FB and examine its consequences on ECM and conduction in a co-culture system of cardiomyocytes (CM) and FB.

Materials: Using short interfering RNA (siRNA), we removed primary cilia in neonatal rat ventricular FB by reducing the expression of Ift88 gene required for ciliary assembly. We co-cultured neonatal rat ventricular cardiomyocytes (CM) with FB previously transfected with Ift88 siRNA (siIft88) or negative control siRNA (siNC) for 48 h. We examined the consequences of ciliated fibroblasts reduction on conduction and tissue remodeling by performing electrical mapping, microelectrode, and gene expression measurements.

Results: Transfection of FB with siIft88 resulted in a significant 60% and 30% reduction of relative Ift88 expression in FB and CM-FB co-cultures, respectively, compared to siNC. Knockdown of Ift88 significantly increased the expression of ECM genes Fn1, Col1a1 and Ctgf by 38%, 30% and 18%, respectively, in comparison to transfection with siNC. Conduction velocity (CV) was significantly decreased in the siIft88 group in comparison to siNC [11.12 ± 4.27 cm/s (n = 10) vs. 17.00 ± 6.20 (n = 10) respectively, p < 0.05]. The fraction of sites with interelectrode activation block was larger in the siIft88 group than in the siNC group (6.59 × 10−2 ± 8.01 × 10−2 vs. 1.18 × 10−2 ± 3.72 × 10−2 respectively, p < 0.05). We documented spontaneous reentrant arrhythmias in two cultures in the siIft88 group and in none of the siNC group. Action potentials were not significantly different between siNC and siIft88 groups.

Conclusion: Disruption of cilia formation by siIft88 causes ECM remodeling and conduction abnormalities. Prevention of cilia loss could be a target for prevention of arrhythmias.
Comparison of zinc bioavailability in zinc-glycine and zinc-methionine chelates for broilers fed with a corn-soybean meal diet
Authors: Chen Xiaohui , He Chao , Zhang Keying , Wang Jianping , Ding Xuemei , Zeng Qiufeng , Peng Huanwei , Bai Jie , Lv Li , Xuan Yue , Bai Shiping
Published: November 2022

The objective of this study was to compare the bioavailability of zinc (Zn) from zinc-glycine (Zn-Gly) and zinc-methionine (Zn-Met) as compared with zinc sulfate (ZnSO4) used as a standard in broilers. A total of 1,200 one-day-old male broilers (Cobb 500) were randomly allotted to one of 10 treatments with eight replicate cages of 15 birds each. The broilers were fed a corn-soybean meal basal diet (containing 26.46 mg Zn/kg; control) or the basal diet added with 40, 80, and 120 mg Zn/kg as Zn-Gly, Zn-Met, or ZnSO4 for 14 days. The relative bioavailability value (RBV) was calculated based on multiple linear regression slope ratios of Zn concentrations in tibia and pancreas, pancreas metallothionein (MT) concentration, and pancreas MT mRNA abundance on added Zn intake. When comparing the control with all Zn-supplemented treatments, Zn addition did not significantly affect average feed intake and bodyweight gain during days 1–14 (p > 0.10). However, Zn concentrations in the tibia, pancreas, and liver and pancreas MT concentration and MT mRNA abundance increased in all Zn-supplemented treatments compared with the control (p < 0.05), and these indices increased linearly (p < 0.001) with increasing added Zn levels on days 7 and 14. The RBV of Zn as Zn-Met was similar to that as Zn-Gly or ZnSO4 (p > 0.40) on days 7 and 14, based on tibia and pancreas Zn. In contrast, on days 7 and 14, the RBVs of Zn were in the following order: Zn-Met > Zn-Gly > ZnSO4 (p < 0.05), based on pancreas MT concentration. The bioavailable Zn from Zn-Met was 1.20 or 1.25 times that from Zn-Gly on day 7 or 14, respectively, evaluated by pancreas MT content. The RBV of Zn as Zn-Met was similar to that as Zn-Gly or ZnSO4 on day 7, whereas it was higher than that as Zn-Gly or ZnSO4 on day 14, based on pancreas MT mRNA abundance. In conclusion, Zn-Met had higher bioavailable Zn than Zn-Gly for the starter broilers fed with the corn-soybean meal diet, using pancreas MT concentration as the response criterion.
Application of crop wild relatives in modern breeding: An overview of resources, experimental and computational methodologies
Authors: Tirnaz Soodeh , Zandberg Jaco , Thomas William J. W. , Marsh Jacob , Edwards David , Batley Jacqueline
Published: November 2022

Global agricultural industries are under pressure to meet the future food demand; however, the existing crop genetic diversity might not be sufficient to meet this expectation. Advances in genome sequencing technologies and availability of reference genomes for over 300 plant species reveals the hidden genetic diversity in crop wild relatives (CWRs), which could have significant impacts in crop improvement. There are many ex-situ and in-situ resources around the world holding rare and valuable wild species, of which many carry agronomically important traits and it is crucial for users to be aware of their availability. Here we aim to explore the available ex-/in- situ resources such as genebanks, botanical gardens, national parks, conservation hotspots and inventories holding CWR accessions. In addition we highlight the advances in availability and use of CWR genomic resources, such as their contribution in pangenome construction and introducing novel genes into crops. We also discuss the potential and challenges of modern breeding experimental approaches (e.g. de novo domestication, genome editing and speed breeding) used in CWRs and the use of computational (e.g. machine learning) approaches that could speed up utilization of CWR species in breeding programs towards crop adaptability and yield improvement.
Sustainable Cannabis Nutrition: Elevated root-zone phosphorus significantly increases leachate P and does not improve yield or quality
Authors: Westmoreland F. Mitchell , Bugbee Bruce
Published: November 2022

Phosphorus (P) is an essential but often over-applied nutrient in agricultural systems. Because of its detrimental environmental effects, P fertilization is well studied in crop production. Controlled environment agriculture allows for precise control of root-zone P and has the potential to improve sustainability over field agriculture. Medical Cannabis is uniquely cultivated for the unfertilized female inflorescence and mineral nutrition can affect the yield and chemical composition of these flowers. P typically accumulates in seeds, but its partitioning in unfertilized Cannabis flowers is not well studied. Here we report the effect of increasing P (25, 50, and 75 mg P per L) in continuous liquid fertilizer on flower yield, cannabinoid concentration, leachate P, nutrient partitioning, and phosphorus use efficiency (PUE) of a high-CBD Cannabis variety. There was no significant effect of P concentration on flower yield or cannabinoid concentration, but there were significant differences in leachate P, nutrient partitioning, and PUE. Leachate P increased 12-fold in response to the 3-fold increase in P input. The P concentration in the unfertilized flowers increased to more than 1%, but this did not increase yield or quality. The fraction of P in the flowers increased from 25 to 65% and PUE increased from 31 to 80% as the as the P input decreased from 75 to 25 mg per L. Avoiding excessive P fertilization can decrease the environmental impact of Cannabis cultivation.
Models of mycorrhizal colonization patterns and strategies induced by biostimulator treatments in Zea mays roots
Authors: Pop-Moldovan Victoria , Corcoz Larisa , Stoian Valentina , Moldovan Cristina , Pleșa Anca , Vâtcă Sorin , Stoian Vlad , Vidican Roxana
Published: November 2022

Agronomic inputs and technologies, especially fertilizers, act on the evolution of the symbiotic partnership between arbuscular mycorrhizal fungi and cultivated plants. The use of the MycoPatt method for the assessment of mycorrhizas in maize roots leads to the extraction of large parameter databases with an increased resolution over the colonization mechanism. The application of a biostimulator treatment on plants acted toward a reduction of root permissiveness for mycorrhizas. The phenomenon was noticeable through an increased colonization variability that overlapped with plant nutritional needs. The annual characteristic of the plant was highlighted by the simultaneous presence of arbuscules and vesicles, with a high share of arbuscules in the advanced phenophases. Colonized root parts presented numerous arbuscule-dominated areas in all phenophases, which indicated a continuous formation of these structures and an intense nutrient transfer between partners. Mycorrhizal maps showed the slowing effect of the biostimulators on colonization, with one phenophase delay in the case of biostimulated plants compared to the ones without biostimulators. The forecast models presented gradual colonization in plants without biostimulators, with the expansion of new hyphal networks. The use of biostimulators on plants exhibited a lower permissiveness for new colonization areas, and the mechanism relies on hyphae developed in the former phenophases.
MINI BODY1, encoding a MATE/DTX family transporter, affects plant architecture in mungbean (Vigna radiata L.)
Authors: Li Xin , Jia Yahui , Sun Mingzhu , Ji Zikun , Zhang Hui , Qiu Dan , Cai Qiao , Xia Yan , Yuan Xingxing , Chen Xin , Shen Zhenguo
Published: November 2022

It has been shown that multidrug and toxic compound extrusion/detoxification (MATE/DTX) family transporters are involved in the regulation of plant development and stress response. Here, we characterized the mini body1 (mib1) mutants in mungbean, which gave rise to increased branches, pentafoliate compound leaves, and shortened pods. Map-based cloning revealed that MIB1 encoded a MATE/DTX family protein in mungbean. qRT-PCR analysis showed that MIB1 was expressed in all tissues of mungbean, with the highest expression level in the young inflorescence. Complementation assays in Escherichia coli revealed that MIB1 potentially acted as a MATE/DTX transporter in mungbean. It was found that overexpression of the MIB1 gene partially rescued the shortened pod phenotype of the Arabidopsis dtx54 mutant. Transcriptomic analysis of the shoot buds and young pods revealed that the expression levels of several genes involved in the phytohormone pathway and developmental regulators were altered in the mib1 mutants. Our results suggested that MIB1 plays a key role in the control of plant architecture establishment in mungbean.
Characterization of the genetic and regulatory networks associated with sugar and acid metabolism in apples via an integrated strategy
Authors: Shen Fei , Hu Chenyang , Huang Xin , Wu Ruigang , Luo Shuzhen , Xu Chengnan , Zhang Hong , Wang Xuan , Zhao Jirong
Published: November 2022

Although sugars and acids have a substantial influence on the taste of apple fruits, the genetic and regulatory networks underlying their metabolism in fruit remain insufficiently determined. To fully decipher the genetic basis of the accumulation of sugars and acids in apple fruits, we adopted an integrated strategy that included time-course RNA-seq, QTL mapping, and whole-genome sequencing to examine two typical cultivars (‘HanFu’ and ‘Huahong’) characterized by distinctive flavors. Whole-genome sequencing revealed substantial genetic variation between the two cultivars, thereby providing an indication of the genetic basis of the distinct phenotypes. Constructed co-expression networks yielded information regarding the intra-relationships among the accumulation of different types of metabolites, and also revealed key regulatory nodes associated with the accumulation of sugars and acids, including the genes MdEF2, MdPILS5, and MdGUN8. Additionally, on the basis of QTL mapping using a high-density genetic map, we identified a series of QTLs and functional genes underlying vital traits, including sugar and acid contents. Collectively, our methodology and observations will provide an important reference for further studies focusing on the flavor of apples.
CEOs' psychological trait and firms' adoption of blockchain technology: The role of hometown identity
Authors: Wang Liang , Xiao Wenyi , Xie Shiyu , Wei Ru
Published: November 2022

The impact of CEOs' psychological traits on firms' decision-making has been explored by many psychological researchers. What's more, the CEO hometown identity, as one of the most fundamental psychological traits, has drawn increasing attention from the psychological literature. Firms' adoption of blockchain technology plays an innovative and efficient role in firms' strategic transformation. Thus, it is necessary to investigate the relationship between CEOs' psychological traits and firms' adoptions of blockchain technology from the perspective of hometown identity. To examine the impact of the CEO hometown identity on firms' adoption of blockchain technology, this paper manually collects information about the CEO hometown identity and constructs the index of firms' adoption of blockchain technology based on the textual analysis of firms' annual reports. Based on the theory about the psychology of identity, this paper constructs the theoretical hypothesis about the relationship between CEO hometown identity and firms' adoption of blockchain technology. Then, this paper uses a two-way fixed effect regression model to estimate the impact of the CEO hometown identity on firms' adoption of blockchain technology based on the panel data of Chinese A-share non-financial listed firms during 2008–2019. The research results show that: (1) the CEO hometown identity has a positive effect on firms' adoption of blockchain technology. (2) For firms with severe financing constraints and State-owned enterprises (SOEs), the positive effect of the CEO hometown identity on firms' adoption of blockchain technology is more prominent. (3) Our benchmark results still hold after a series of robustness checks, including altering the measurement of the CEO hometown identity, altering the sample, adding CEO-specific control variables, and altering the logit regression model. Based on the above-mentioned findings, this paper not only sheds new light on the power of CEOs' psychological trait but also deepens the understanding about theories of the psychology of identity.
A man-made divide: Investigating the effect of urban–rural household registration and subjective social status on mental health mediated by loneliness among a large sample of university students in China
Authors: Yu Hui , Xu Shicun , Li Hui , Wang Xiaofeng , Sun Qian , Wang Yuanyuan
Published: November 2022

Introduction

The urban–rural household registration system in China has been documented with profound social consequences in almost all areas of people’s life. This study aims to investigate the underlying mechanism of the rural and urban discrepancies on mental health conditions among a large sample of college students in China.

Methods

A survey was distributed among college students in China. A total of 96,218 college students from 63 colleges completed the survey, answering questions on their urban–rural household registration, disposable household income, subjective social status, feelings of loneliness, and anxiety and depression symptoms. Confirmatory Factor Analysis (CFA) and Structural Equation Modelling (SEM) analyses were conducted, testing the effect of urban–rural registration on one’s mental health, mediated by subjective social status, and loneliness.

Results

Structural Equation Modelling (SEM) results revealed that the urban–rural household registration showed a direct effect on anxiety (B = −0.03, 95% CI [−0.038, −0.022], β = −0.03, p < 0.001) and depression (B = −0.03, 95% CI [−0.035, −0.023], β = −0.03, p < 0.001), indicating that rural household registration had a negative association with anxiety and depression symptoms, albeit the standardised estimate being very small. The indirect path from the urban–rural registration mediated through subjective social status and loneliness to anxiety and depression was both significant, with B = 0.01, 95% CI [0.010, 0.010], β = 0.01, p < 0.001, and B = 0.01, 95% CI [0.0090, 0.0090], β = 0.01, p < 0.001, respectively. The results of the indirect paths demonstrated that students of the rural household registration reported higher anxiety and depression symptoms through a lower subjective social status and higher level of loneliness.

Conclusion

This study indicated that decreasing the disparity of social status and tackling loneliness is the key to improve the overall mental health of college students. The urban–rural household registration system may have a very small direct effect on the college students’ mental health; but students of urban registration enjoyed higher subjective social status, which had a clear protective effect against anxiety and depression symptoms.
Corpus-based analysis of shifts in China’s diplomatic stance across seven decades (1949–2018)
Authors: Tian Xujun , Li Xiaoqian
Published: November 2022

This study investigates the changes in China’s diplomacy in the past seven decades based on the diachronic corpus of Chinese diplomatic discourse from 1949 to 2018 using corpus based critical discourse analysis theoretical insights. The study examines the targeted keywords used in the seven periods of Chinese diplomatic discourse and their significant collocations. The results show that China has worked with the United States, Japan, the United Kingdom, and some Asian, Latin American, and African countries to safeguard world peace while opposing war, establish good relations with these countries, and promote mutual development through cooperation. In addition, China’s diplomacy has experienced politics-oriented and economy-oriented eras and is now in an era of global sustainable development. Therefore, Chinese diplomatic discourse is the linguistic representation of China’s diplomacy, fundamentally determined by its national interests and changing social and historical situations domestically and internationally.
Need for training or already OnTracc? Development and psychometric properties of an online transcultural competence questionnaire among psychotherapists
Authors: Atzor Marie-Christin , Piegenschke Katharina , Christiansen Hanna
Published: November 2022

The prevalence of mental disorders among people with migration experiences is high. Studies have shown that despite the increasing number of patients from different cultures requiring therapy, treating them is still a major challenge. Furthermore, professional training aimed at improving transcultural competence is rare, and psychometric instruments assessing transcultural competence require improvement. Accordingly, this study aimed to develop and evaluate an online transcultural competence questionnaire (OnTracc) to assess transcultural competence among psychotherapists. Based on extensive literature research and expert interviews, 38-self-report statements referring to aspects of transcultural therapy (e.g., skills, knowledge, and awareness) were compiled. In two studies, 306 psychotherapists completed the OnTracc questionnaire. The multicultural counseling inventory (MCI), personality factors (BFI-K), experience in transcultural therapy, and demographic data were assessed as control variables. The exploratory factor analysis (EFA) revealed a 3-factor structure. The reliability of the scale ranged from ω = 0.73 to 0.81. These scales demonstrated substantial convergent and discriminant validity with the BFI-K and MCI subscales. Factorial validity was confirmed through confirmatory factor analysis. This validated inventory is the first to assess transcultural competence in therapeutic settings in the German language. Further analysis of the factorial validity of the different samples is recommended. Given the increasing diversity in the therapeutic landscape, additional development could help close the gap between the evolving treatment demands of culturally diverse patients and the lack of consideration in mental health and education.
Relationship between psychological capital and depression in Chinese physicians: The mediating role of organizational commitment and coping style
Authors: Sun Li , Zhang Yuan , He Jingyun , Qiao Kexin , Wang Ce , Zhao Shuai , Zhao Jinxin , Qiu Xiaohui , Yang Xiuxian , Zhou Jiawei , Bu Tianyi , Hu Xiaomeng , Qiao Zhengxue , Cao Depin , Yang Yanjie
Published: November 2022

Background

It is well known that the medical profession is a high-risk practice, with intense work and complex situations. The physicians are prone to suffer from depression due to occupational stress under high workloads for long periods of time. Depression not only impairs physicians’ mental health, but also affects the quality of health services, so it is important to explore the factors and mechanisms affecting depression among physicians.

Methods

In this cross-sectional study, 1,139 physicians from Heilongjiang Province were surveyed by cluster sampling procedures. The questionnaires included Psychological Capital Questionnaire, Chinese Employee Organizational Commitment Questionnaire, Trait Coping Style Questionnaire and Self-rating Depression Scale. Pearson correlation analysis and Bootstrap were used for statistical analysis.

Results

This study found that 41.6% of physicians suffering from depression. Among them, 17.0% of physicians showed moderate depression, and 2.6% of physicians exhibited severe depression. The serial-multiple mediation of organizational commitment and positive coping styles in the relationship between psychological capital and depression was significant.

Conclusion

The results showed that the psychological capital was sequentially associated with increased organizational commitment, and then increased positive coping styles, which resulted in reduced depression among physicians.
The impact of background music on film audience’s attentional processes: Electroencephalography alpha-rhythm and event-related potential analyses
Authors: Kwon Young-Sung , Lee Jonghyun , Lee Slgi (Sage)
Published: November 2022

Background music is an indispensable part of films and plays an important role in enhancing audiences’ attention to scenes. However, few studies have examined the cognitive effect of background music at the neurophysiological level. Using electroencephalography (EEG), the present study examines the effect of background music tempo on the viewer’s attentional processes. Participants’ (N = 24) EEG responses were recorded while the participants watched segments of action films in three conditions with variations on the presence and tempo of background music (i.e., no background music vs. slow-tempo music vs. fast-tempo music). These responses were analyzed using the alpha-rhythm suppression and event-related potential (ERP) P300, a brainwave indicator of attentional processes. The results suggest that participants’ attention levels increased when background music was present (compared to when background music was absent), but there was no difference in participants’ attention levels based on tempo. The theoretical and practical implications of these findings are discussed.
Adolescents’ own views on their risk behaviors, and the potential effects of being labeled as risk-takers: A commentary and review
Authors: Defoe Ivy N. , Rap Stephanie E. , Romer Daniel
Published: November 2022

Adolescents are stereotypically viewed as risk-takers (“stereotypical risk-takers”) in science, mainstream media, fictional literature and in everyday life. However, increasing research suggests that adolescents do not always engage in “heightened” risk-taking, and adolescents’ own perspectives (motives) on risk-taking are largely neglected in research. Hence, this paper is a commentary and review with two aims. First, taking a cross-national perspective, we discuss the definition of adolescence and risk behavior. We argue that much of the research on what drives adolescent risk behavior (e.g., substance use) focuses on the harms that this behavior promotes rather than on the need to explore and grow into adulthood. Thereafter we summarize the dominant approach to studying motives behind substance use, which has mostly considered young adults, and which has typically not focused on adolescents’ own self-generated motives. The few empirical studies (including one of our qualitative studies) on adolescents’ own motivations for engaging in risk behavior (i.e., cannabis use, alcohol use, and tobacco smoking) show that the most frequently mentioned motives by adolescents were being cool/tough, enjoyment, belonging, having fun and experimenting and coping. Interestingly, the “cool/tough identity” motive is virtually overlooked in research on adolescent risk-taking. The above-mentioned motives, however, generally support newer theories, such as the Developmental Neuro-Ecological Risk-taking Model (DNERM) and the Life-span Wisdom Model that suggest that adolescents’ motivations to engage in risk-taking include experimentation, identity development, explorative behavior, and sensation seeking, all of which run counter to the stereotype of adolescents engaging in risk-taking due to “storm and stress.” Hence, we also briefly consider additional recent attempts to study positive forms of risk taking. Second, extrapolating from sociological/criminological theories on labeling, we suggest that caution is warranted when (inaccurately) labeling adolescents as the “stereotypical risk-takers,” because this can instigate a risk-taking identity in adolescents and/or motivate them to associate with risk-taking peers, which could in turn lead to maladaptive forms of risk-taking. Empirical research testing these hypotheses is needed. To conclude we argue that research on adolescent risk-taking could further benefit from considering adolescent’s own motivations, which is also in line with the participatory approach advocated by international children’s rights standards.
Social norms and fertility intentions: Evidence from China
Authors: Yu Xiao , Liang Jianing
Published: November 2022

China’s low fertility rates are a major concern across all sectors of society. Fertility is a major issue related to economy, society and family development. Based on social norms theory, this paper explores the influence of social norms on individuals’ fertility intentions from two perspectives: spatial proximity and social proximity. Using data from the China Family Panel Studies, we found that individual’s fertility intentions were influenced by social norms; both neighborhood social norms and group social norms had significant effects. The role of social norms in shaping individual fertility intentions varied by gender, hukou, and life course; specifically, men, rural residents, and married individuals were more significantly influenced by social norms. This study improves the theoretical framework of fertility decision making by arguing that in addition to macro and individual factors, social norms have a very important influence on fertility intentions. Our findings suggest that reshaping social norms regarding fertility is essential to enhance fertility rates in China.
Spontaneous motor tempo contributes to preferred music tempo regardless of music familiarity
Authors: Hine Kyoko , Abe Koki , Kinzuka Yuya , Shehata Mohammad , Hatano Katsunobu , Matsui Toshie , Nakauchi Shigeki
Published: November 2022

Music, and listening to music, has occurred throughout human history. However, it remains unclear why people prefer some types of music over others. To understand why we listen to a certain music, previous studies have focused on preferred tempo. These studies have reported that music components (external), as well as participants’ spontaneous motor tempo (SMT; internal), determine tempo preference. In addition, individual familiarity with a piece of music has been suggested to affect the impact of its components on tempo preference. However, the relationships among participants’ SMT, music components, and music familiarity as well as the influence of these variables on tempo preference have not been investigated. Moreover, the music components that contribute to tempo preference and their dependence on familiarity remain unclear. Here, we investigate how SMT, music components, and music familiarity simultaneously regulate tempo preference as well as which music components interact with familiarity to contribute to tempo preference. A total of 23 participants adjusted the tempo of music pieces according to their preferences and rated the familiarity of the music. In addition, they engaged in finger tapping at their preferred tempo. Music components, such as the original tempo and the number of notes, were also analyzed. Analysis of the collected data with a linear mixed model showed that the preferred tapping tempo of participants contributed to the preferred music tempo, regardless of music familiarity. In contrast, the contributions of music components differed depending on familiarity. These results suggested that tempo preference could be affected by both movement and memory.
Life stories: Unraveling the academic configuration of a multifaceted and multidisciplinary field of knowledge
Authors: López-Montero Rocío , García-Navarro Carmen , Delgado-Baena Antonio , Vela-Jiménez Rocío , Sianes Antonio
Published: November 2022

In the field of qualitative research, life stories are consolidated as one of the most important techniques within the biographical method. However, due to the multiplicity of techniques covered by this method and the disciplines in which it is applied, the contributions and scope of life histories do not present a clear delimitation. By contrast, a considerable conceptual confusion persists and the transfer of its production remains very narrow. In this sense, this article aims to clarify the field of knowledge generated through life stories. To this end, it innovatively applies the bibliometric method. Making use of performance analysis and scientific mapping through the VosViewer application, it studies a body of 2670 articles indexed in the Web of Science. The results show how knowledge transferred from psychology through its major schools of thought occupies a central place. This leaves in a secondary position the knowledge produced by other disciplines such as sociology or anthropology, which is not transferred in the main forums of scientific impact. In this way, the conclusion points to the need to open up new lines of research to find out the differences between the different techniques and disciplines when applying this methodology.
The influence of differential leadership on employees’ deviant innovation behavior: An outsider subordinate perspective
Authors: Wu Mengyun , Zhu Yuqing , He Qi , Zhang Luan , Lu Jie
Published: November 2022

Given the complex business environment worldwide and rapid development of information technologies, employees’ deviant innovation behavior has attracted increasing attention. However, few scholars have explored the internal mechanism of the influence of differential leadership on the deviant innovation behavior of outsider subordinates from a positive perspective. Based on relative deprivation theory and attribution theory, we construct a theoretical model to study the influence of differential leadership in family businesses on the deviant innovation behavior of outsider subordinates, and hypothesis testing is conducted based on 243 questionnaire responses. The result shows that: differential leadership has a positive impact on the deviant innovation behavior of outsider subordinates; relative deprivation plays a mediating role; and internal control personality enhances the moderation effect between relative deprivation and outsider subordinates’ deviant innovation behavior. This study provides a reference point for the promotion of the innovation performance both of employees and organizations.
Promoting wellbeing and empowerment via Youth First: Exploring psychosocial outcomes of a school-based resilience intervention in Bihar, India
Authors: Leventhal Katherine S. , Cooper Peter L. , DeMaria Lisa M. , Priyam Priyadarshi , Shanker Hari , Andrew Gracy , Leventhal Steve
Published: November 2022

Youth worldwide are struggling with increased mental health concerns. As youth in low- and middle-income countries make up more than 20% of the world’s population, finding ways to improve their psychosocial wellbeing is crucial. CorStone’s Youth First program is a school-based psychosocial resilience program that seeks to improve the mental, physical, social, and educational wellbeing of early adolescents. The program is delivered via trained government schoolteachers who facilitate students’ learning and development in small groups using a discussion and activity-based curriculum. In August 2021, a study among 322 adolescents was conducted to investigate and compare program participants’ and non- participants’ understanding and use of inter- and intra-personal psychosocial skills. Focus group discussions were held with students in eight intervention schools and four comparable schools not receiving the intervention (control). Through the focus group discussions, students provided their opinions, thoughts, and ideas about vignettes describing challenges that youth in their communities frequently face, including early marriage and financial pressures. Analysis integrated qualitative and quantitative approaches, consisting of an iterative thematic analysis process followed by quantizing data and conducting t-tests. Youth who had received Youth First had greater awareness of problems, perspective-taking, problem-solving strategies, helping approaches, awareness of their own strengths, and visions for the future, when compared with the control group. Findings provide insights into potential outcomes for measurement in future evaluations of mental health promotion and prevention programs among youth in low- and middle-income countries.