bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation of the Robustness of Therapeutic Drug Monitoring Coupled with Bayesian Forecasting of Busulfan with Regard to Inaccurate Documentation
Authors: Dadkhah Adrin , Alihodzic Dzenefa , Broeker Astrid , Kröger Nicolaus , Langebrake Claudia , Wicha Sebastian G.
Published: October 2021

Background

Inaccurate documentation of sampling and infusion times is a potential source of error in personalizing busulfan doses using therapeutic drug monitoring (TDM). Planned times rather than the actual times for sampling and infusion time are often documented.

Therefore, this study aimed to evaluate the robustness of a limited sampling TDM of busulfan with regard to inaccurate documentation.

Methods

A pharmacometric analysis was conducted in NONMEM® 7.4.3 and “R” by performing stochastic simulation and estimation with four, two and one sample(s) per patient on the basis of a one-compartment- (1CMT) and two-compartment (2CMT) population pharmacokinetic model. The dosing regimens consisted of i.v. busulfan (0.8 mg/kg) every 6 h (Q6H) or 3.2 mg/kg every 24 h (Q24H) with a 2 h- and 3 h infusion time, respectively. The relative prediction error (rPE) and relative root-mean-square error (rRmse) were calculated in order to determine the accuracy and precision of the individual AUC estimation.

Results

A noticeable impact on the estimated AUC based on a 1CMT-model was only observed if uncertain documentation reached ± 30 min (1.60% for Q24H and 2.19% for Q6H). Calculated rPEs and rRmse for Q6H indicate a slightly lower level of accuracy and precision when compared to Q24H. Spread of rPE’s and rRmse for the 2CMT-model were wider and higher compared to estimations based on a 1CMT-model.

Conclusions

The estimated AUC was not affected substantially by inaccurate documentation of sampling and infusion time. The calculated rPEs and rRmses of estimated AUC indicate robustness and reliability for TDM of busulfan, even in presence of erroneous records.
Litter inputs and phosphatase activity affect the temporal variability of organic phosphorus in a tropical forest soil in the Central Amazon
Authors: Schaap Karst J. , Fuchslueger Lucia , Hoosbeek Marcel R. , Hofhansl Florian , Martins Nathielly Pires , Valverde-Barrantes Oscar J. , Hartley Iain P. , Lugli Laynara F. , Quesada Carlos Alberto
Published: October 2021

Purpose

The tropical phosphorus cycle and its relation to soil phosphorus (P) availability are a major uncertainty in projections of forest productivity. In highly weathered soils with low P concentrations, plant and microbial communities depend on abiotic and biotic processes to acquire P. We explored the seasonality and relative importance of drivers controlling the fluctuation of common P pools via processes such as litter production and decomposition, and soil phosphatase activity.

Methods

We analyzed intra-annual variation of tropical soil phosphorus pools using a modified Hedley sequential fractionation scheme. In addition, we measured litterfall, the mobilization of P from litter and soil extracellular phosphatase enzyme activity and tested their relation to fluctuations in P- fractions.

Results

Our results showed clear patterns of seasonal variability of soil P fractions during the year. We found that modeled P released during litter decomposition was positively related to change in organic P fractions, while net change in organic P fractions was negatively related to phosphatase activities in the top 5 cm.

Conclusion

We conclude that input of P by litter decomposition and potential soil extracellular phosphatase activity are the two main factors related to seasonal soil P fluctuations, and therefore the P economy in P impoverished soils. Organic soil P followed a clear seasonal pattern, indicating tight cycling of the nutrient, while reinforcing the importance of studying soil P as an integrated dynamic system in a tropical forest context.
Auditing versus monitoring and the role of commitment
Authors: Jost Peter-J.
Published: October 2021

This paper studies the effect of timing and commitment of verification in a principal-agent relationship with moral hazard. To acquire additional information about the agent’s behavior, the principal possesses a costly technology that produces a noisy signal about the agent’s effort choice. The precision of this signal is affected by the principal’s verification effort. Two verification procedures are discussed: monitoring where the principal verifies the agent’s behavior simultaneously with his effort choice and auditing where the principal can condition her verification effort on the realized outcome. As it is well known, the principal prefers to audit the agent’s behavior if she can commit to her verification effort at the time of contracting. The main contribution of this paper is to highlight the importance of commitment by the principal to her verification effort. In particular, I show that, when the principal cannot commit to her verification effort ex-ante, the principal strictly prefers monitoring to auditing if the gains from choosing high effort are sufficiently high.
A Little Less Conversation, a Little More Action: Participatory Insider Action Research in an Executive Team
Authors: Kenefick David , Kirrane Melrona
Published: October 2021

In this paper, we describe a Participatory Insider Action Research (PIAR) intervention within the Executive Committee (EC) of a large publicly funded service for people with intellectual disabilities. I was a member of this EC and had been for 20 years. The intervention ran over a two-year period and comprised three cycles of PIAR. We addressed two specific organisational issues but our work did not deliver change in these areas in a substantial sense. We identify power dynamics and role duality challenges as the core factors that contributed to this outcome and describe their effects in this under-researched domain. We finish by offering some advice for future researchers undertaking initiatives of this nature.
Effects of organic mulching on soil aggregate stability and aggregate binding agents in an urban forest in Beijing, China
Authors: Zhou Wei , Sun Xiangyang , Li Suyan , Du Tiantian , Zheng Yi , Fan Zhihui
Published: October 2021

Urban forest soil is often disturbed by rapid urbanization. Organic mulching is effective for improving soil quality and aggregate stability. This study evaluated how soil binding agents changed aggregate stability through organic mulching in urban forest soils. Three treatments were applied in Jiufeng National Forest Park, Beijing: (1) no organic mulch (control); (2) wood chips alone (5 cm thickness); and, (3) wood chips + wood compost (This mulch was divided into two layers, the upper layer of wood chips (2.5 cm), the lower layer wood compost (2.5 cm)). Soil samples were collected from the surface 10- cm soil layer and fraction into four aggregates. Glomalin-related soil protein and soil organic carbon were measured in bulk soil and the four aggregates. The results show that wood chips + wood compost increased the proportion of large and small macroaggregates, mean weight diameter and geometric mean diameter. The total and easily extractable glomalin-related soil protein were higher in the wood chips + wood compost. However, soil organic carbon was lower in the wood chips alone application compared to the controls and wood chips + wood compost. Easily extractable / total glomalin-related soil protein and glomalin-related soil protein / soil organic carbon ratios of wood chips alone and wood chips + wood compost had increased trend compared to the controls but did not reach significant levels (p > 0.05). Mean weight diameter and geometric mean diameter correlated positively with total and easily extractable glomalin-related soil protein but were not positively correlated with soil organic carbon, the ratios of easily extractable and total glomalin-related soil protein, and the ratios of glomalin-related soil protein and soil organic carbon. Redundancy analysis revealed that total glomalin-related soil protein was the most important driver for soil aggregate stability, especially the total glomalin-related soil protein of small macroaggregates. The results suggest that wood chips + wood compost enhanced soil aggregate stability through the increase of glomalin-related soil protein. Wood chips alone cannot enhance soil aggregate stability in urban forests in the short term.
Ant colony optimization for feasible scheduling of step-controlled smart grid generation
Authors: Bremer Jörg , Lehnhoff Sebastian
Published: October 2021

The electrical energy grid is currently experiencing a paradigm shift in control. In the future, small and decentralized energy resources will have to responsibly perform control tasks like frequency or voltage control. For many use cases, scheduling of energy resources is necessary. In the multi-dimensional discrete case–e.g.,  for step-controlled devices–this is an NP-hard problem if some sort of intermediate energy buffer is involved. Systematically constructing feasible solutions during optimization, hence, becomes a difficult task. We prove the NP-hardness for the example of co-generation plants and demonstrate the multi-modality of systematically designing feasible solutions. For the example of day-ahead scheduling, a model-integrated solution based on ant colony optimization has already been proposed. By using a simulation model for deciding on feasible branches, artificial ants construct the feasible search graphs on demand. Thus, the exponential growth of the graph in this combinatorial problem is avoided. We present in this extended work additional insight into the complexity and structure of the underlying the feasibility landscape and additional simulation results.
Diversity and endemism of the flora of Ethiopia and Eritrea: state of knowledge and future perspectives
Authors: Demissew Sebsebe , Friis Ib , Weber Odile
Published: October 2021

Understanding biodiversity of plants depends on detailed knowledge of floristics and environmental parameters. According to the Flora of Ethiopia and Eritrea (FEE; 1989–2009), the latest academic flora of these two topographically complex countries, the number of taxa (including non-indigenous ones) is 6027 of which 647 are endemic. Since 2009, 56 indigenous taxa have been described from the FEE area. Based on FEE data and later information, the number of indigenous species is here counted at 5219. In the RAINBIO database Sosef et al. (BMC Biol 15:1–23, 2017) counted the number of indigenous species in Ethiopia at 4481 (Eritrea not counted). Studies of local diversity and endemism produce different results with varying methods and sources: FEE data show highest diversity in the southern part of Ethiopia near the borders with Kenya, while RAINBIO data show highest diversity in the south-west and around the town of Harar. Wang et al. (J Syst Evol 58(1):33–42, 2020) found the highest ‘weighted endemism’ in the central Ethiopian mountains, while our FEE data indicates highest single-region endemism near the borders with Kenya and Somalia; Hawthorne and Marshall (Gard Bull Singap 71(Suppl. 2):315–333, 2019), weighting species according to rarity, found the highest ‘bioquality score’ in the same areas as our highest single-region endemism. Studies of altitudinal diversity show a ‘mid-elevation diversity bulge’ at 1400–2100 m a.s.l. More data are needed before we understand the complex diversity of the two countries, including altitudinal diversity. We review needs for additional data gathering and modelling that may help answering outstanding questions.

Graphic abstract
Transoral thyroid surgery vestibular approach: is there an increased risk of surgical site infections?
Authors: Karakas Elias , Klein Günther , Michlmayr Linda , Schardey Martin , Schopf Stefan ,   The Endoscopic Thyroid and Parathyroid Surgery Study Group
Published: October 2021

Transoral endoscopic thyroidectomy vestibular approach (TOETVA) is an upcoming surgical technique with the aim to optimize cosmetic outcome avoiding visible scars in the neck. However, the transoral access bears the risk of contamination and microbial allocation from the mouth into the thyroid region. Therefore, some authors recommend extended antibiotic therapy up to 7 days after surgery. Our aim was to evaluate infection rates and parameters before and after transoral surgery and to suggest a viable and safe routine in transoral surgery. Prospectively collected data of patients who were eligible for transoral surgery in Austria and Germany between June 2017 and July 2020 were retrospectively evaluated focussing on clinical and laboratory infection signs pre and postoperatively. White blood cell count (WBC) and C-reactive protein levels (CRP) were estimated before and after surgery. Patients` characteristics, surgical outcome and complications were also determined and compared to the current results reported in the literature. 113 transoral operations were performed in 108 patients. In 37 of 108 (36%) patients an additional retroauricular incision in the hairline and in two patients a submental skin incision was performed to extract thyroid specimen of more than 40 ml. Intravenous antibiotic prophylaxis and enoral mucosal disinfection were used in all patients before surgery. WBC and CRP levels were available in 75 patients. Median WBC was 5800/µl (range 3500–10,500/µl) before and significantly higher (median 8900/µl, range 4500–18,800 µl; p < 0.01) at day one after surgery. WBC returned to normal range (4500–11,500/µl) in all patients within the first 7 days postoperatively (median 5300/µl, range 3400–8700/µl). CRP levels were normal before (< 0.5 mg/dl) and slightly elevated within the first two days after surgery (Median 2.0 mg/dl, range 0.5–6.4 mg/dl, n.s.). In one patient oral antibiotic therapy was necessary due to transient erythema in the chin region which occurred 10 days after surgery and resolved completely without surgical intervention. Despite a transient increase in WBC transoral thyroid and parathyroid surgery via the vestibular approach does not seem to be associated with a significant number of wound infections in our patients. Intravenous antibiotic prophylaxis and enoral mucosal disinfection might be reasonable procedures to avoid microbial allocation from the mouth into the thyroid region. However, further investigations are required to finally estimate the need of antibiotics in transoral surgery.
A data-based structural health monitoring approach for damage detection in steel bridges using experimental data
Authors: Svendsen Bjørn T. , Frøseth Gunnstein T. , Øiseth Ole , Rønnquist Anders
Published: October 2021

There is a need for reliable structural health monitoring (SHM) systems that can detect local and global structural damage in existing steel bridges. In this paper, a data-based SHM approach for damage detection in steel bridges is presented. An extensive experimental study is performed to obtain data from a real bridge under different structural state conditions, where damage is introduced based on a comprehensive investigation of common types of steel bridge damage reported in the literature. An analysis approach that includes a setup with two sensor groups for capturing both the local and global responses of the bridge is considered. From this, an unsupervised machine learning algorithm is applied and compared with four supervised machine learning algorithms. An evaluation of the damage types that can best be detected is performed by utilizing the supervised machine learning algorithms. It is demonstrated that relevant structural damage in steel bridges can be found and that unsupervised machine learning can perform almost as well as supervised machine learning. As such, the results obtained from this study provide a major contribution towards establishing a methodology for damage detection that can be employed in SHM systems on existing steel bridges.
Impact-sliding wear response of 2.25Cr1Mo steel tubes: Experimental and semi-analytical method
Authors: Yin Meigui , Thibaut Chaise , Wang Liwen , Nélias Daniel , Zhu Minhao , Cai Zhenbing
Published: October 2021

The impact-sliding wear behavior of steam generator tubes in nuclear power plants is complex owing to the dynamic nature of the mechanical response and self-induced tribological changes. In this study, the effects of impact and sliding velocity on the impact-sliding wear behavior of a 2.25Cr1Mo steel tube are investigated experimentally and numerically. In the experimental study, a wear test rig that can measure changes in the impact and friction forces as well as the compressive displacement over different wear cycles, both in real time, is designed. A semi-analytical model based on the Archard wear law and Hertz contact theory is used to predict wear. The results indicate that the impact dynamic effect by the impact velocity is more significant than that of the sliding velocity, and that both velocities affect the friction force and wear degree. The experimental results for the wear depth evolution agree well with the corresponding simulation predictions.
Nanoengineered Shear-Thinning Hydrogel Barrier for Preventing Postoperative Abdominal Adhesions
Authors: Ruiz-Esparza Guillermo U. , Wang Xichi , Zhang Xingcai , Jimenez-Vazquez Sofia , Diaz-Gomez Liliana , Lavoie Anne-Marie , Afewerki Samson , Fuentes-Baldemar Andres A. , Parra-Saldivar Roberto , Jiang Nan , Annabi Nasim , Saleh Bahram , Yetisen Ali K. , Sheikhi Amir , Jozefiak Thomas H. , Shin Su Ryon , Dong Nianguo , Khademhosseini Ali
Published: October 2021

More than 90% of surgical patients develop postoperative adhesions, and the incidence of hospital re-admissions can be as high as 20%. Current adhesion barriers present limited efficacy due to difficulties in application and incompatibility with minimally invasive interventions. To solve this clinical limitation, we developed an injectable and sprayable shear-thinning hydrogel barrier (STHB) composed of silicate nanoplatelets and poly(ethylene oxide). We optimized this technology to recover mechanical integrity after stress, enabling its delivery though injectable and sprayable methods. We also demonstrated limited cell adhesion and cytotoxicity to STHB compositions in vitro. The STHB was then tested in a rodent model of peritoneal injury to determine its efficacy preventing the formation of postoperative adhesions. After two weeks, the peritoneal adhesion index was used as a scoring method to determine the formation of postoperative adhesions, and STHB formulations presented superior efficacy compared to a commercially available adhesion barrier. Histological and immunohistochemical examination showed reduced adhesion formation and minimal immune infiltration in STHB formulations. Our technology demonstrated increased efficacy, ease of use in complex anatomies, and compatibility with different delivery methods, providing a robust universal platform to prevent postoperative adhesions in a wide range of surgical interventions.
Immune Checkpoint Inhibitor-induced Pneumonitis: Incidence, Clinical Characteristics, and Outcomes
Authors: Banavasi Harsha , Kim Seongho , Alkassis Samer , Daoud Asil , Laktineh Amir , Nagasaka Misako , Sukari Ammar , Soubani Ayman O.
Published: October 2021

Background:

Immune checkpoint inhibitors (ICIs) are the newest class of anticancer drugs. Pneumonitis is increasingly being recognized as a potential complication of these agents.

Methods:

We conducted a retrospective study of patients who received ICIs at a comprehensive cancer center. We collected data on demographics, type of malignancy, type of ICI agent, incidence of pneumonitis up to 6 weeks after receiving ICI agent, clinical characteristics, and risk factors for overall survival in patients who develop pneumonitis.

Results:

A total of 654 patients received ICIs during the study period. The most common type of cancer for which ICI was given was adenocarcinoma of the lung (29%), followed by renal cell cancer (12%) and squamous cell lung cancer (12%). Among the study patients, 41% received nivolumab and 32% received pembrolizumab. Other patients in the study received combination of ICIs or ICI plus chemotherapeutic agent, or were part of clinical trial involving ICI. Overall 42 (6.4%) patients developed pneumonitis within 6 weeks after the last dose of treatment of any ICI agent. Of these, 81% of patients had Grade ≥ 2 pneumonitis and 45% of these required hospital admission for pneumonitis, with 10% of them requiring admission to intensive care unit. Overall, patients who received pembrolizumab-containing regimen, had prior chemotherapy, or who never had cancer-related surgery had increased risk of death.

Conclusion:

Our large retrospective study shows real-life data of incidence of pneumonitis in patients who are treated with ICIs for cancer treatment. Our data indicate that the incidence of pneumonitis is overall lower than that reported previously with relatively good outcomes.
Prescriber's Guide – Children and Adolescents
Authors: Stahl Stephen M.
Published: October 2021

Child and adolescent psychopharmacology is a rapidly growing field with psychotropic medications used widely in the treatment of this patient group. However, psychopharmacological treatment guidelines used for adults cannot simply be applied for children or adolescents, thus presenting clinicians and nurse practitioners with assessment and prescribing challenges. Based on the best-selling resource Stahl's Prescriber's Guide, this new book provides a user-friendly step-by-step manual on the range of psychotropic drugs prescribed for children and adolescents by clinicians and nurse practitioners. Reviewed by expert child and adolescent psychiatrists, the medications are presented in the same design format in order to facilitate rapid access to information. Each drug is broken down into a number of sections, each designated by a unique color background thereby clearly distinguishing information presented on therapeutics, safety and tolerability, dosing and use, what to expect, special populations, and the art of psychopharmacology, and followed by key references.
Canada’s Pro-Ban Stance on Double-Hatting: Playing the Long Game in ISDS Reform?
Authors: LÉVESQUE CÉLINE
Published: October 2021

The practice of arbitrators and counsel in investor-state dispute settlement (ISDS) cases simultaneously playing both roles — known as “double-hatting” — has been the subject of much controversy in recent debates on ISDS reform, notably, at the United Nations Commission on International Trade Law’s (UNCITRAL) Working Group III where a Draft Code of Conduct for Adjudicators in International Investment Disputes is under discussion. While Canada has been less than consistent in its approaches to ISDS in recent international investment agreements (IIAs), its position against double-hatting has been rather constant. This article explores whether this stance reveals a commitment on the part of Canada towards increased judicialization of ISDS or reflects a “flavour of the month” reform likely to change with differing IIAs and negotiating partners. Analysis of Canada’s recent IIA practices, including its model Foreign Investment Promotion and Protection Agreement, released in May 2021, and the positions it has taken at UNCITRAL’s Working Group III, lead the author to conclude that Canada appears committed to increased judicialization of ISDS in the long run.
Cocycles on groupoids arising from -actions
Authors: FARSI CARLA , HUANG LEONARD , KUMJIAN ALEX , PACKER JUDITH
Published: October 2021

We consider groupoids constructed from a finite number of commuting local homeomorphisms acting on a compact metric space and study generalized Ruelle operators and
$ C^{\ast } $
-algebras associated to these groupoids. We provide a new characterization of
$ 1 $
-cocycles on these groupoids taking values in a locally compact abelian group, given in terms of
$ k $
-tuples of continuous functions on the unit space satisfying certain canonical identities. Using this, we develop an extended Ruelle–Perron–Frobenius theory for dynamical systems of several commuting operators (
$ k $
-Ruelle triples and commuting Ruelle operators). Results on KMS states on
$ C^{\ast } $
-algebras constructed from these groupoids are derived. When the groupoids being studied come from higher-rank graphs, our results recover existence and uniqueness results for KMS states associated to the graphs.
The Moral Parameters of Violence: The Case of the Provisional IRA
Authors: Frampton Martyn
Published: October 2021

Over three decades, the Provisional Irish Republican Army waged a campaign of violence that claimed the lives of some two thousand people. This article explores the moral framework by which the IRA sought to legitimate its campaign—how it was derived and how it functioned. On the one hand, the IRA relied on a legalist set of political principles, grounded in a particular reading of Irish history. An interlinked, yet discrete strand of legitimation stressed the iniquities of the Northern Irish state as experienced by Catholic nationalists, especially in the period 1968–1972. These parallel threads were interwoven to build a powerful argument that justified a resort to what the IRA termed its “armed struggle.” Yet the IRA recognized that the parameters for war were set not simply by reference to ideology but also by a reading of what might be acceptable to those identified as “the people” or “the community.” Violence was subject to an undeclared process of negotiation with multiple audiences, which served to constitute the boundaries of the permissible. Often, these red lines were revealed only at the point of transgression, but they were no less important for being intangible. An examination of the moral parameters for IRA violence provides a new perspective on the group, helping to explain IRA resilience but also its ultimate weakness and decline.
A Dangerous Loophole: the Biological Weapons Convention's New Interpretation that Better Addresses Potentially Deadly Biological Research
Authors: Raxter Lena
Published: October 2021

There are three types of weapons of mass destruction (WMDs)—nuclear, chemical, and biological. Of the three WMDs, biological weapons are arguably the most dangerous as they are the most indiscriminate, the least controllable, and the least expensive to create. The seminal treaty for establishing legal constraints on this vital issue is the 1972 Biological Weapons Convention (BWC).2 Article I of the BWC specifically outlaws State acquisition of “microbial or other biological agents, or toxins whatever their origin or method of production, of types and in quantities that have no justification for prophylactic, protective or other peaceful purposes . . .”3

The Vienna Convention on the Law of Treaties4 (VCLT) provides the general rule for how to interpret treaty language: “a treaty shall be interpreted in good faith in accordance with the ordinary meaning to be given to the terms of the treaty in their context and in the light of its object and purpose.”5 Problematically, by reading the BWC in light of this general rule, because the BWC only prohibits acquisitions that have “no justification,” the ordinary meaning of the text creates a wide loophole through which States may argue the acquisition of a potentially prohibited material has some justification, however minor, and therefore is not prohibited.

The Comment first reviews the background of biological weapons and regulation of their use. In this section, the Comment also describes the VCLT requirements for treaty interpretation and the evolutive approach to interpretation. Next, the Comment conducts a global analysis of State practice in regards to biosafety and biosecurity regulatory measures. It then analyzes the BWC using the various treaty interpretation methods—including addressing how subsequent state practice has affected this interpretation, and how an evolutive approach to interpretation changes the meaning of Article I of the BWC. Lastly, in recognition of this evolution in the law, this Comment recommends how to update enforcement mechanisms to accurately reflect the new state of the law.
No Longer Turning a Blind Eye to International Atrocities: Reframing Foreign Officials’ Functional Immunity as a Breach of States' International Legal Obligations to Effectively Prohibit Derogations from Peremptory Norms
Authors: Rawls Ariel
Published: October 2021

On January 29, 2020, an Israeli air strike proved fatal, taking the lives of an entire family, a twelve-year-old child the youngest among them. The airstrike was carried out as part of Israel's military operation, Operation Protective Edge, in the Gaza Strip, and despite the deaths of numerous civilians, the State of Israel alleged that the strike was committed in pursuance of official duties. Ismail Zeyada, whose mother, brothers, sister-in-law, and nephew all perished in the airstrike, initiated a civil suit in the Netherlands against the two former Israeli military officials involved. In a devastating blow to the victims and their families, the District Court of the Hague dismissed the civil proceeding brought against the former Israeli officers. The Court cited the doctrine of functional immunity as the basis for this decision. The functional immunity, or immunity ratione materiae, of these officials bars the prosecution of them in any state besides Israel, absent a waiver by the Israeli government. As such, the victims of the airstrike, an act that might amount to a war crime, is not one for which victims are being offered redress. Although domestic prosecution of the case before Israeli courts is theoretically possible and is not precluded by the District Court of the Hague's dismissal, domestic prosecution is neither likely to occur nor likely to result in fair redress for the victims of this atrocity. This is not the justice these victims deserve. And it is not the justice that international law assures them.
Shallow firn cores 1989–2019 in southwest Greenland's percolation zone reveal decreasing density and ice layer thickness after 2012
Authors: Rennermalm Åsa K. , Hock Regine , Covi Federico , Xiao Jing , Corti Giovanni , Kingslake Jonathan , Leidman Sasha Z. , Miège Clément , Macferrin Michael , Machguth Horst , Osterberg Erich , Kameda Takao , McConnell Joseph R.
Published: October 2021

Refreezing of meltwater in firn is a major component of Greenland ice-sheet's mass budget, but in situ observations are rare. Here, we compare the firn density and total ice layer thickness in the upper 15 m of 19 new and 27 previously published firn cores drilled at 15 locations in southwest Greenland (1850–2360 m a.s.l.) between 1989 and 2019. At all sites, ice layer thickness covaries with density over time and space. At the two sites with the earliest observations (1989 and 1998), bulk density increased by 15–18%, in the top 15 m over 28 and 21 years, respectively. However, following the extreme melt in 2012, elevation-detrended density using 30 cores from all sites decreased by 15 kg m−3 a−1 in the top 3.75 m between 2013 and 2019. In contrast, the lowest elevation site's density shows no trend. Thus, temporary build-up in firn pore space and meltwater infiltration capacity is possible despite the long-term increase in Greenland ice-sheet melting.
Modeling and base parameters identification of legged robots
Authors: Chang Xu , An Honglei , Ma Hongxu
Published: October 2021

This paper first uses a decoupling modeling method to model legged robots. The method groups all the degrees of freedom according to the number of limbs, regarding each limb as a manipulator with serial structure, which greatly reduces the number of dynamic parameters that need to be identified simultaneously. On this basis, a step-by-step identification method from the end-effector link to the base link, referred to as “E-B” identification method, is proposed. Simulation verification is carried out on a quadruped robot with 16 degrees of freedom in Gazebo, and the validity of the method proposed is discussed.
Vision-based kinematic analysis of the Delta robot for object catching
Authors: Kansal Sachin , Mukherjee Sudipto
Published: October 2021

This paper proposes a vision-based kinematic analysis and kinematic parameters identification of the proposed architecture, designed to perform the object catching in the real-time scenario. For performing the inverse kinematics, precise estimation of the link lengths and other parameters needs to be present. Kinematic identification of Delta based upon Model10 implicit model with ten parameters using the iterative least square method is implemented. The loop closure implicit equations have been modelled. In this paper, a vision-based kinematic analysis of the Delta robots to do the catching is discussed. A predefined library of ArUco is used to get a unique solution of the kinematics of the moving platform with respect to the fixed base. The re-projection error while doing the calibration in the vision sensor module is 0.10 pixels. Proposed architecture interfaced with the hardware using the PID controller. Encoders are quadrature and have a resolution of 0.15 degrees embedded in the experimental setup to make the system closed-loop (acting as feedback unit).
Interaction networks between solitary hymenopterans and their natural enemies in different restoration areas
Authors: da Silva Guilherme Gonzaga , Lange Denise , Guillermo-Ferreira Rhainer
Published: October 2021

The diversity of species and their interactions have been positively related with environmental complexity. Therefore, highly anthropized environments have their integrity under serious threat. These effects may last for years compromising the dynamics of natural communities, such as antagonistic and mutualistic interactions, including host-natural enemy interactions. To investigate these effects, trap nest methodology was used to assess the diversity of solitary bees, wasps and their natural enemies in three fragmented environments with different degree of anthropic perturbation, composed of aEucalyptusplantation (considered here as higher perturbation), a Cerrado area (medium perturbation) and a Riparian forest (lesser perturbation). Then, host-natural enemies associations were analysed to verify the size, specialization degree and modularity of interaction network. The gradient from highest to lowest degree of anthropic perturbation was evidenced in the species diversity index, the size of the interaction network and the specialization indexes of the host-natural enemy network. The environment withEucalyptusplantation showed higher values of diversity of natural enemies, greater number of species in the interaction network, lesser degree of specialization in the interaction and lesser modularity, than Cerrado and Riparian forest environments, respectively. The low degree of nestedness and lack of significance of this index to all sampled areas are indicative of a specialized pattern of networks. The results corroborate the notion that human impact may affect interaction networks, this being an important tool for checking the degree of anthropic alteration.
Optimal capital taxation in an economy with innovation-driven growth
Authors: Chen Ping-Ho , Chu Angus C. , Chu Hsun , Lai Ching-Chong
Published: October 2021

This paper investigates optimal capital taxation in an innovation-driven growth model. We examine how the optimal capital tax rate varies with externalities associated with R&D and innovation. Our results show that the optimal capital tax rate is higher when (i) the “stepping on toes effect” is smaller, (ii) the “standing on shoulders effect” is stronger, or (iii) the extent of creative destruction is smaller. The optimal capital tax rate is more likely to be positive when there is underinvestment in R&D. Moreover, the optimal capital tax rate and the monopolistic markup exhibit an inverted-U relationship. By calibrating our model to the US economy, we find that the optimal capital tax rate is positive, at a rate of around 6.6%. Finally, we consider a number of extensions and find that the result of a positive optimal capital tax is robust.
Does repression undermine opposition demands? The case of the Hong Kong National Security Law
Authors: Kobayashi Tetsuro , Song Jaehyun , Chan Polly
Published: October 2021

Does political repression extinguish public support for opposition demands? Protest emerges as a consequence of grievances and political preferences expressed as demands. Although the literature on the repression–dissent nexus has primarily focused on whether repression effectively deters dissenting behavior, a limitation is that researchers do not often distinguish between behavior and preferences. One possible implication is that although the observable protest behavior can be reduced by repression, underlying opposition demands may remain intact or even be strengthened. Hence, the question of why repression should alter public preferences remains theoretically under-investigated, because there is limited micro-level evidence that captures changes in opposition preferences induced by a repressive episode. We fielded comparable conjoint experiments before and after the enactment of the Hong Kong National Security Law in June 2020. Support for the demands was largely stable despite the sweeping powers of the law to curb protests, although some moderation of demands was observed. We outline avenues for future research on mechanisms and implications entailed by the effects of repression on preferences.
Fungal biomarkers are detectable in Martian rock-analogues after space exposure: implications for the search of life on Mars
Authors: Pacelli Claudia , Cassaro Alessia , Baqué Mickael , Selbmann Laura , Zucconi Laura , Maturilli Alessandro , Botta Lorenzo , Saladino Raffaele , Böttger Ute , Demets René , Rabbow Elke , de Vera Jean-Pierre P. , Onofri Silvano
Published: October 2021

Mars is a primary target of astrobiological interest: its past environmental conditions may have been favourable to the emergence of a prebiotic chemistry and, potentially, biological activity. In situ exploration is currently underway at the Mars surface, and the subsurface (2 m depth) will be explored in the future ESA ExoMars mission. In this context, BIOlogy and Mars EXperiment was performed to evaluate the stability and detectability of organic biomarkers under space and Mars-like conditions. Our data suggested that some target molecules, namely melanin, azelaic acid and nucleic acids, can be detected even after 16 months exposure to Low Earth Orbit conditions by multidisciplinary approaches. We used the same techniques as onboard the ExoMars rover, as Raman and infrared spectroscopies and gas chromatograph-mass spectrometer, and polymerase chain reaction even if this is not planned for the imminent mission to Mars. These results should be taken into account for future Mars exploration.
Effect of a multidisciplinary ward-based intervention on end-of-life care for general medicine patients
Authors: Soo Rui Ting Michelle , Nashi Norshima Binte , Ang Lin Elaine Kai , Hooi Benjamin M.Y.
Published: October 2021

Objective

Providing good end-of-life (EOL) care for noncancer patients has been made a national priority in Singapore. A combined medical and nursing ward-based intervention known as the EOL care plan was piloted in a general medicine ward at our institution, aiming to guide key aspects of EOL care. The aim of this study is to assess the EOL care plan's effect on EOL care for general medicine patients.

Method

We conducted a retrospective cohort study on inpatients who died in a general ward under the discipline “General Medicine” from May to October 2019. We collected data around symptom management, rationalization of care and communication with families. The primary analysis compared care received by patients who died in the pilot ward with that of a control group of patients who died in other wards.

Results

In total, 112 records were included in the analysis. Pain assessment was more common in the pilot ward compared with the control group (35.3% vs. 6.3%,p< 0.001), as were anti-psychotic prescriptions for delirium (64.7% vs. 24.4%,p= 0.001). Fewer patients received blood glucose monitoring in the last 48 h of life in the pilot ward (69.5% vs. 35.3%,p= 0.007). There were also less frequent parameters monitoring in the pilot ward (p< 0.004).

Significance of results

The implementation of the EOL care plan was associated with process-level indicators of better EOL care, suggesting that it could have a significant positive impact when implemented on a wider scale.
Optogenetic stimulation of lateral hypothalamic orexin/dynorphin inputs in the ventral tegmental area potentiates mesolimbic dopamine neurotransmission and promotes reward-seeking behaviours
Authors: Thomas Catherine S. , Mohammadkhani Aida , Rana Madiha , Qiao Min , Baimel Corey , Borgland Stephanie L.
Published: October 2021

Reward and reinforcement processes are critical for survival and propagation of genes. While numerous brain systems underlie these processes, a cardinal role is ascribed to mesolimbic dopamine. However, ventral tegmental area (VTA) dopamine neurons receive complex innervation and various neuromodulatory factors, including input from lateral hypothalamic (LH) orexin/hypocretin neurons which also express and co-release the neuropeptide, dynorphin. Dynorphin in the VTA induces aversive conditioning through the Kappa opioid receptor (KOR) and decreases dopamine when administered intra-VTA. Exogenous application of orexin or orexin 1 receptor (oxR1) antagonists in the VTA bidirectionally modulates dopamine-driven motivation and reward-seeking behaviours, including the attribution of motivational value to primary rewards and associated conditioned stimuli. However, the effect of endogenous stimulation of LH orexin/dynorphin-containing projections to the VTA and the potential contribution of co-released dynorphin on mesolimbic dopamine and reward related processes remains uncharacterised. We combined optogenetic, electrochemical, and behavioural approaches to examine this. We found that optical stimulation of LH orexin/dynorphin inputs in the VTA potentiates mesolimbic dopamine neurotransmission in the nucleus accumbens (NAc) core, produces real time and conditioned place preference, and increases the food cue-directed orientation in a Pavlovian conditioning procedure. LH orexin/dynorphin potentiation of NAc dopamine release and real time place preference was blocked by an oxR1, but not KOR antagonist. Thus, rewarding effects associated with optical stimulation of LH orexin/dynorphin inputs in the VTA are predominantly driven by orexin rather than dynorphin.
Ultrafast reorientation of the Néel vector in antiferromagnetic Dirac semimetals
Authors: Ono Atsushi , Ishihara Sumio
Published: October 2021

Antiferromagnets exhibit distinctive characteristics such as ultrafast dynamics and robustness against perturbative fields, thereby attracting considerable interest in fundamental physics and technological applications. Recently, it was revealed that the Néel vector can be switched by a current-induced staggered (Néel) spin-orbit torque in antiferromagnets with the parity-time symmetry, and furthermore, a nonsymmorphic symmetry enables the control of Dirac fermions. However, the real-time dynamics of the magnetic and electronic structures remain largely unexplored. Here, we propose a theory of the ultrafast dynamics in antiferromagnetic Dirac semimetals and show that the Néel vector is rotated in the picosecond timescale by the terahertz-pulse-induced Néel spin-orbit torque and other torques originating from magnetic anisotropies. This reorientation accompanies the modulation of the mass of Dirac fermions and can be observed in real time by the magneto-optical effects. Our results provide a theoretical basis for emerging ultrafast antiferromagnetic spintronics combined with the topological aspects of materials.
Symmetry-resolved entanglement detection using partial transpose moments
Authors: Neven Antoine , Carrasco Jose , Vitale Vittorio , Kokail Christian , Elben Andreas , Dalmonte Marcello , Calabrese Pasquale , Zoller Peter , Vermersch Benoȋt , Kueng Richard , Kraus Barbara
Published: October 2021

We propose an ordered set of experimentally accessible conditions for detecting entanglement in mixed states. The k-th condition involves comparing moments of the partially transposed density operator up to order k. Remarkably, the union of all moment inequalities reproduces the Peres-Horodecki criterion for detecting entanglement. Our empirical studies highlight that the first four conditions already detect mixed state entanglement reliably in a variety of quantum architectures. Exploiting symmetries can help to further improve their detection capabilities. We also show how to estimate moment inequalities based on local random measurements of single state copies (classical shadows) and derive statistically sound confidence intervals as a function of the number of performed measurements. Our analysis includes the experimentally relevant situation of drifting sources, i.e. non-identical, but independent, state copies.
Newly regenerated axons via scaffolds promote sub-lesional reorganization and motor recovery with epidural electrical stimulation
Authors: Siddiqui Ahad M. , Islam Riazul , Cuellar Carlos A. , Silvernail Jodi L. , Knudsen Bruce , Curley Dallece E. , Strickland Tammy , Manske Emilee , Suwan Parita T. , Latypov Timur , Akhmetov Nafis , Zhang Shuya , Summer Priska , Nesbitt Jarred J. , Chen Bingkun K. , Grahn Peter J. , Madigan Nicolas N. , Yaszemski Michael J. , Windebank Anthony J. , Lavrov Igor A.
Published: October 2021

Here, we report the effect of newly regenerated axons via scaffolds on reorganization of spinal circuitry and restoration of motor functions with epidural electrical stimulation (EES). Motor recovery was evaluated for 7 weeks after spinal transection and following implantation with scaffolds seeded with neurotrophin producing Schwann cell and with rapamycin microspheres. Combined treatment with scaffolds and EES-enabled stepping led to functional improvement compared to groups with scaffold or EES, although, the number of axons across scaffolds was not different between groups. Re-transection through the scaffold at week 6 reduced EES-enabled stepping, still demonstrating better performance compared to the other groups. Greater synaptic reorganization in the presence of regenerated axons was found in group with combined therapy. These findings suggest that newly regenerated axons through cell-containing scaffolds with EES-enabled motor training reorganize the sub-lesional circuitry improving motor recovery, demonstrating that neuroregenerative and neuromodulatory therapies cumulatively enhancing motor function after complete SCI.
Updating the Chieti Affective Action Videos database with older adults
Authors: La Malva Pasquale , Ceccato Irene , Di Crosta Adolfo , Marin Anna , Fasolo Mirco , Palumbo Riccardo , Mammarella Nicola , Palumbo Rocco , Di Domenico Alberto
Published: October 2021

Validation of the Chieti Affective Action Videos (CAAV) database was replicated with a sample of older adults (age range 65–93). When designing experimental studies of emotions, it is crucial to take into consideration the differences in emotional processing between young and older adults. Therefore, the main goal of the present study was to provide an appropriate dataset for the use of CAAV in aging research. For this reason, the CAAV administration and the data collection methodology was faithfully replicated in a sample of 302 older adults. All the 360 standardized stimuli were evaluated on the emotional dimensions of valence and arousal. The CAAV validation in an older adults’ population increases the potential use of this innovative tool. The present validation supports the use of the CAAV database in future experimental studies on cognitive functions in healthy and pathological aging.