bluuebunny/crossref_metadata_2025 huggingface dataset:
Oral Rehabilitation of Hypodontia Patients Using an Endosseous Dental Implant: Functional and Aesthetic Results
Authors: Attia Sameh , Schaaf Heidrun , El Khassawna Thaqif , Malhan Deeksha , Mausbach Katharina , Howaldt Hans-Peter , Streckbein Philipp
Published: October 2019

Hypodontia often leads to limited bone availability of the alveolar ridges. Oral rehabilitation of severe hypodontia patients is challenging. In this retrospective study, we evaluated the functional and aesthetic results after dental implants in hypodontia patients, corroborated by Albrektsson implant success criteria. Over a period of 15 years (2000–2015), a total of 43 patients were diagnosed with hypodontia and 165 dental implants were inserted. Six patients who received 10 implants were lost in the follow-up. We examined 155 implants in 37 patients between December 2015 and May 2017. Besides family history, patients evaluated the general satisfaction, functionality, and aesthetics of the implants. Study subjects were between 17 and 44 years old (mean ± SD: 21.4 ± 5.6). Hypodontia patients were missing one to five teeth (n = 28), whereas patients diagnosed with oligodontia (≥6 missing teeth, n = 9). In this study, 24 patients (64.9%) with hypodontia had a positive family history; the remaining 13 patients had no family member with hypodontia. The final follow-up time ranged between 5 and 189 months after implant placement. Orthodontic treatment was performed in 32 patients (86%) before implant placement. Rehabilitation resulted in 62% of the cases being treated with 1–2 implants and 38% treated with 3–15 implants. However, out of 155 inserted dental implants, 18 implants failed to meet Albrektsson criteria, under which two implants were removed. Only autografts were used for bone augmentation with 97 implants. More than two-thirds of the patients showed high general satisfaction and masticatory function (69.4%) as well as phonetic ability (80.6%). The aesthetic outcome was rated as excellent by 17 patients (47.2%). The findings emphasize the importance of interdisciplinary treatment of hypodontia, leading to a satisfactory, functional, and long-term fixed prosthodontics using dental implants.
Serum Immunoglobulin Levels in Children with Sickle Cell Disease: A Large Prospective Study
Authors: Cherif-Alami Sophia , Hau Isabelle , Arnaud Cécile , Kamdem Annie , Coulon Basil , Idoux Elodie , Bechet Stéphane , Creidy Rita , Bernaudin Françoise , Epaud Ralph , Pondarré Corinne
Published: October 2019

Over the past 3 decades, the pediatric department of the university Intercommunal Créteil hospital, a referral center for sickle cell disease (SCD), has prospectively evaluated immunoglobulin (Ig) levels in a cohort of 888 children with SCD, including 731 with severe sickle genotypes (HbSS and HbSβ0 thalassemia) and 157 with milder genotypes (HbSC and HbSβ+ thalassemia). We found consistent sickle genotype differences in levels of IgG and IgA, with increased levels of IgA and IgG in the severe versus milder genotype, from early childhood to late adolescence. Additionally, our results revealed a low serum IgM level, irrespective of sickle genotype. Finally, we found that IgA and IgG levels were significantly increased after therapeutic intensification with hydroxyurea but were stabilized in children receiving a transfusion program. The mechanisms contributing to these changes in Ig levels are unclear as is their clinical significance. We believe they should be further investigated.
Influence of Laminin Coating on the Autologous In Vivo Recellularization of Decellularized Vascular Protheses
Authors: Toshmatova Mahfuza , Nakanishi Sentaro , Sugimura Yukiharu , Schmidt Vera , Lichtenberg Artur , Assmann Alexander , Akhyari Payam
Published: October 2019

Decellularization of non-autologous biological implants reduces the immune response against foreign tissue. Striving for in vivo repopulation of aortic prostheses with autologous cells, thereby improving the graft biocompatibility, we examined surface coating with laminin in a standardized rat implantation model. Detergent-decellularized aortic grafts from donor rats (n = 37) were coated with laminin and systemically implanted into Wistar rats. Uncoated implants served as controls. Implant re-colonization and remodeling were examined by scanning electron microscopy (n = 10), histology and immunohistology (n = 18). Laminin coating persisted over eight weeks. Two weeks after implantation, no relevant neoendothelium formation was observed, whereas it was covering the whole grafts after eight weeks, with a significant acceleration in the laminin group (p = 0.0048). Remarkably, the intima-to-media ratio, indicating adverse hyperplasia, was significantly diminished in the laminin group (p = 0.0149). No intergroup difference was detected in terms of medial recellularization (p = 0.2577). Alpha-smooth muscle actin-positive cells originating from the adventitial surface invaded the media in both groups to a similar extent. The amount of calcifying hydroxyapatite deposition in the intima and the media did not differ between the groups. Inflammatory cell markers (CD3 and CD68) proved negative in coated as well as uncoated decellularized implants. The coating of decellularized aortic implants with bioactive laminin caused an acceleration of the autologous recellularization and a reduction of the intima hyperplasia. Thereby, laminin coating seems to be a promising strategy to enhance the biocompatibility of tissue-engineered vascular implants.
Fatigue Behavior of Concrete Beams Prestressed with Partially Bonded CFRP Bars Subjected to Cyclic Loads
Authors: Jeong Yoseok , Kim WooSeok , Gribniak Viktor , Hui David
Published: October 2019

The lack of ductility is the greatest concern in the applications of carbon fiber reinforced polymer (CFRP) materials, when used as pre-stressing reinforcements. To improve the ductility, a partially bonded FRP system which is intentionally unbonded in the middle part of the beam and bonded in both end parts of the beam has been developed and applied to prestressed concrete beams. While, many researchers investigated the instantaneous performance of partially bonded CFRP prestressed concrete beams, this study intended to evaluate the fatigue performance, the static load-carrying capacity after fatigue loading and ductility. Based on the fatigue loading tests followed by static loading tests, over-reinforced and web-confined partially bonded CFRP prestressed concrete beams exhibited satisfactory fatigue performance without cracks and stiffness degradation during fatigue loading. In addition, no degradation of load-carrying capacity was observed in static loading tests after the fatigue tests. The ductility index of concrete beams, prestressed with partially bonded CFRP bars, is combined with over-reinforcements and web-confinements, similar to that of beams prestressed with steel bars.
Size and Shape-Dependent Solubility of CuO Nanostructures
Authors: Leitner Jindřich , Sedmidubský David , Jankovský Ondřej
Published: October 2019

In our theoretical study, the enhanced solubility of CuO nanoparticles in water saturated by air is predicted based on a simple thermodynamic model. CuO is considered in the form of nanoparticles with various shapes. The interfacial energy of a solid CuO/dilute aqueous solution interface was assessed by applying the average CuO surface energy and contact angle of a sessile drop of water. The equilibrium CuO solubility was calculated using Gibbs energy minimization technique. For the smallest spherical nanoparticles considered in this work (r = 2 nm), the solubility is significantly higher than the solubility of bulk material. In the case of cylindrical nanoparticles, the solubility increase is even more considerable. The CuO spherical nanoparticles solubility was also calculated using the Ostwald–Freundlich equation which is known to overestimate the solubility as discussed in this contribution.
Experimental Tests on Fiber-Reinforced Alkali-Activated Concrete Beams Under Flexure: Some Considerations on the Behavior at Ultimate and Serviceability Conditions
Authors: Monfardini Linda , Facconi Luca , Minelli Fausto
Published: October 2019

Alkali-activated concrete (AAC) is an alternative concrete typology whose innovative feature, compared to ordinary concrete, is represented by the use of fly ash as a total replacement of Portland cement. Fly ash combined with an alkaline solution and cured at high temperature reacts to form a geopolymeric binder. The growing interest in using AACs for structural applications comes from the need of reducing the global demand of Portland cement, whose production is responsible for about 9% of global anthropogenic CO2 emissions. Some research studies carried out in the last few years have proved the ability of AAC to replace ordinary Portland cement concrete in different structural applications including the construction of beams and panels. On the contrary, few experimental results concerning the structural effectiveness of fiber-reinforced AAC are currently available. The present paper presents the results of an experimental program carried out to investigate the flexural behavior of full-scale AAC beams reinforced with conventional steel rebars, in combination with fibers uniformly spread within the concrete matrix. The experimental study included two beams containing 25 kg/m3 (0.3% in volume) of high-strength steel fibers and two beams reinforced with 3 kg/m3 (0.3% in volume) of synthetic fibers. A reference beam not containing fibers was also tested. The discussion of the experimental results focuses on some aspects significant for the structural behavior at ultimate limit states (ULS) and serviceability limit states (SLS). The discussion includes considerations on the flexural capacity and ductility of the test specimens. About the behavior at the SLS, the influence of fiber addition on the tension stiffening mechanism is discussed, together with the evolution of post-cracking stiffness and of the mean crack spacing. The latter is compared with the analytical predictions provided by different formulations developed over the past 40 years and adopted by European standards.
Dynamic Pullout Behavior of Multiple Steel Fibers in UHPC: Effects of Fiber Geometry, Inclination Angle, and Loading Rate
Authors: Jang Eun-Yoo , Kim Jung J. , Yoo Doo-Yeol
Published: October 2019

This study examined the influences of fiber geometry, inclination angle, and loading rate on the pullout behavior of multiple steel fibers in ultra-high-performance concrete (UHPC). For this, two different steel fiber types, i.e., straight (S-) and hooked (H-), four different inclination angles (0°–60°), and four different loading rates (0.018 mm/s to 1200 mm/s) were considered. Test results indicated that the pullout performance of S-fibers in UHPC was improved by increasing the loading rate. The highest maximum pullout load of the S-fiber was obtained at the inclination angle of 30° or 45°. The maximum pullout loads of H-fibers also increased with increases in the loading rate, while their slip capacities rather decreased. No specific inclination angle was identified in the case of H-fibers that caused the highest maximum pullout load. The H-fibers yielded higher average bond strengths than S-fibers, but similar or even smaller pullout energies under the impact loads. The aligned S-fiber in UHPC was most sensitive to the loading rate compared to the inclined S-fiber and aligned H-fiber. The rate sensitivity became moderate with the fiber inclination angle. Consequently, the aligned S-fiber was recommended to achieve the best energy absorption capacity and interfacial bond strength at various impact loads.
Weighted Method for Uncertain Nonlinear Variational Inequality Problems
Authors: Li Cunlin , Postolache Mihai , Jia Zhifu
Published: October 2019

A convex combined expectations regularized gap function with uncertain variable is presented to deal with uncertain nonlinear variational inequality problems (UNVIP). The UNVIP is transformed into a minimization problem through an uncertain weighted expected residual function. Moreover, the convergence of the global optimal solutions of the uncertain weighted expected residual minimization model is given through the integration by parts method under the compact space of the uncertain event. The limiting behaviors of the transformed model are analyzed. Furthermore, a compact approximation method is proposed in the unbounded uncertain event space. Through analysis of the convergence of UWERM model and reasonable hypothesis, the compact approximation method is verified under the circumstance of Holder continuity.
Separable Reversible Data Hiding in Encrypted Image Based on Two-Dimensional Permutation and Exploiting Modification Direction
Authors: Yu Chunqiang , Ye Chenmei , Zhang Xianquan , Tang Zhenjun , Zhan Shanhua
Published: October 2019

In this paper, we propose a separable reversible data hiding method in encrypted image (RDHEI) based on two-dimensional permutation and exploiting modification direction (EMD). The content owner uses two-dimensional permutation to encrypt original image through encryption key, which provides confidentiality for the original image. Then the data hider divides the encrypted image into a series of non-overlapping blocks and constructs histogram of adjacent encrypted pixel errors. Secret bits are embedded into a series of peak points of the histogram through EMD. Direct decryption, data extraction and image recovery can be performed separately by the receiver according to the availability of encryption key and data-hiding key. Different from some state-of-the-art RDHEI methods, visual quality of the directly decrypted image can be further improved by the receiver holding the encryption key. Experimental results demonstrate that the proposed method outperforms some state-of-the-art methods in embedding capacity and visual quality.
Determination of Directional Residual Stresses by the Contour Method
Authors: Hodek Josef , Prantl Antonín , Džugan Jan , Strunz Pavel
Published: October 2019

This study evaluated residual stresses in heat-treated specimens made of 316L stainless steel using FE analysis and compared them with stresses determined by the contour method. Contour method is usually used just for evaluation of residual stresses that are normal to the cut plan. In the current study this approach is extended and both normal and tangential stresses are determined. The specimens were cut using wire electrical discharge machine and the contours of the cut were measured using a coordinate measuring machine. The prior treatment of the specimens was simulated using the finite-element method. An appropriate boundary condition and temperature-dependent material model were employed. The finite-element model was validated against neutron-diffraction measurement data. The results showed a good agreement in normal and tangential directions of stress.
Shortcomings of International Standard ISO 9223 for the Classification, Determination, and Estimation of Atmosphere Corrosivities in Subtropical Archipelagic Conditions—The Case of the Canary Islands (Spain)
Authors: Santana Juan J. , Ramos Alejandro , Rodriguez-Gonzalez Alejandro , Vasconcelos Helena C. , Mena Vicente , Fernández-Pérez Bibiana M. , Souto Ricardo M.
Published: October 2019

The classification, assessment, and estimation of the atmospheric corrosivity are fixed by the ISO 9223 standard. Its recent second edition introduced a new corrosivity category for extreme environments CX, and defined mathematical models that contain dose–response functions for normative corrosivity estimations. It is shown here that application of the ISO 9223 standard to archipelagic subtropical areas exhibits major shortcomings. Firstly, the corrosion rates of zinc and copper exceed the range employed to define the CX category. Secondly, normative corrosivity estimation would require the mathematical models to be redefined introducing the time of wetness and a new set of operation constants.
Janthinobacterium CG23_2: Comparative Genome Analysis Reveals Enhanced Environmental Sensing and Transcriptional Regulation for Adaptation to Life in an Antarctic Supraglacial Stream
Authors: Dieser Markus , Smith Heidi J. , Ramaraj Thiruvarangan , Foreman Christine M.
Published: October 2019

As many bacteria detected in Antarctic environments are neither true psychrophiles nor endemic species, their proliferation in spite of environmental extremes gives rise to genome adaptations. Janthinobacterium sp. CG23_2 is a bacterial isolate from the Cotton Glacier stream, Antarctica. To understand how Janthinobacterium sp. CG23_2 has adapted to its environment, we investigated its genomic traits in comparison to genomes of 35 published Janthinobacterium species. While we hypothesized that genome shrinkage and specialization to narrow ecological niches would be energetically favorable for dwelling in an ephemeral Antarctic stream, the genome of Janthinobacterium sp. CG23_2 was on average 1.7 ± 0.6 Mb larger and predicted 1411 ± 499 more coding sequences compared to the other Janthinobacterium spp. Putatively identified horizontal gene transfer events contributed 0.92 Mb to the genome size expansion of Janthinobacterium sp. CG23_2. Genes with high copy numbers in the species-specific accessory genome of Janthinobacterium sp. CG23_2 were associated with environmental sensing, locomotion, response and transcriptional regulation, stress response, and mobile elements—functional categories which also showed molecular adaptation to cold. Our data suggest that genome plasticity and the abundant complementary genes for sensing and responding to the extracellular environment supported the adaptation of Janthinobacterium sp. CG23_2 to this extreme environment.
Sulfides Formation in Carbothermic Reduction of Saprolitic Nickel Laterite Ore Using Low-Rank Coals and Additives: A Thermodynamic Simulation Analysis
Authors: Harjanto Sri , Rhamdhani M. Akbar
Published: October 2019

In this paper, a systematic thermodynamic analysis of carbothermic reduction of saprolitic nickel laterite ore was carried out. Different carbon sources—such as pure C, sub-bituminous, and lignite—were used for the carbothermic reduction at 1000 °C (1273 K). The effect of the different additives—such as S, FeS, Na2S, Na2SO4, and CaSO4—was also systematically evaluated. The thermodynamic calculations suggested that the use of low rank coals (sub-bituminous and lignite) do not significantly affect the nickel grade and nickel recovery, but affect the total metals recovery. The presence of S in these C-sources promoted the formation of sulfides. At 1000 °C (1273 K), only a small amount of C-sources (C, sub-bituminous, lignite) are needed to significantly metallize the nickel in the laterite, i.e., between 4–6 wt %. The additives S, FeS, Na2S, Na2SO4, and CaSO4 were predicted to promote the formation of liquid sulfides, and at the same time reduce the formation of the (Fe,Ni) alloy, thus reducing the nickel and total metals recovery. Therefore, consideration is needed to balance the two aspects. The calculations predicted that S, Na2SO4, and CaSO4 additions provided an increase in the nickel grade; while FeS and Na2S reduced the nickel grade.
Amine Modification of Silica Aerogels/Xerogels for Removal of Relevant Environmental Pollutants
Authors: Lamy-Mendes Alyne , Torres Rafael B. , Vareda João P. , Lopes David , Ferreira Marco , Valente Vanessa , Girão Ana V. , Valente Artur J. M. , Durães Luísa
Published: October 2019

Serious environmental and health problems arise from the everyday release of industrial wastewater effluents. A wide range of pollutants, such as volatile organic compounds, heavy metals or textile dyes, may be efficiently removed by silica materials advanced solutions such as aerogels. This option is related to their exceptional characteristics that favors the adsorption of different contaminants. The aerogels performance can be selectively tuned by an appropriate chemical or physical modification of the aerogel’s surface. Therefore, the introduction of amine groups enhances the affinity between different organic and inorganic contaminants and the silica aerogels. In this work, different case studies are reported to investigate and better understand the role of these functional groups in the adsorption process, since the properties of the synthesized aerogels were significantly affected, regarding their microstructure and surface area. In general, an improvement of the removal efficiency after functionalization of aerogels with amine groups was found, with removal efficiencies higher than 90% for lead and Rubi Levafix CA. To explain the adsorption mechanism, both Langmuir and Freundlich models were applied; chemisorption is most likely the sorption type taking place in the studied cases.
Antioxidant Saffron and Central Retinal Function in ABCA4-Related Stargardt Macular Dystrophy
Authors: Piccardi Marco , Fadda Antonello , Martelli Francesco , Marangoni Dario , Magli Adriano , Minnella Angelo M. , Bertelli Matteo , Di Marco Stefano , Bisti Silvia , Falsini Benedetto
Published: October 2019

Retinal oxidative damage, associated with an ATP-binding cassette, sub-family A, member 4, also known as ABCA4 gene mutation, has been implicated as a major underlying mechanism for Stargardt disease/fundus flavimaculatus (STG/FF). Recent findings indicate that saffron carotenoid constituents crocins and crocetin may counteract retinal oxidative damage, inflammation and protect retinal cells from apoptosis. This pilot study aimed to evaluate central retinal function following saffron supplementation in STG/FF patients carrying ABCA4 mutations. Methods: in a randomized, double-blind, placebo-controlled study (clinicaltrials.gov: NCT01278277), 31 patients with ABCA4-related STG/FF and a visual acuity >0.25 were randomly assigned to assume oral saffron (20 mg) or placebo over a six month period and then reverted to P or S for a further six month period. Full ophthalmic examinations, as well as central 18° focal electroretinogram (fERG) recordings, were performed at baseline and after six months of either saffron or placebo. The fERG fundamental harmonic component was isolated by Fourier analysis. Main outcome measures were fERG amplitude (in µV) and phase (in degrees). The secondary outcome measure was visual acuity. Results: supplement was well tolerated by all patients throughout follow-up. After saffron, fERG amplitude was unchanged; after placebo, amplitude tended to decrease from baseline (mean change: −0.18 log µV, p < 0.05). Reverting the treatments, amplitude did not change significantly. fERG phase and visual acuity were unchanged throughout follow-up. Conclusions: short-term saffron supplementation was well tolerated and had no detrimental effects on the electroretinographic responses of the central retina and visual acuity. The current findings warrant further long-term clinical trials to assess the efficacy of saffron supplementation in slowing down the progression of central retinal dysfunction in ABCA4-related STG/FF.
Prevalence of Medication-Dietary Supplement Combined Use and Associated Factors
Authors: Aznar-Lou Ignacio , Carbonell-Duacastella Cristina , Rodriguez Ana , Mera Inés , Rubio-Valera Maria
Published: October 2019

Introduction: The use of medication has increased in recent years in the US while the use of dietary supplements has remained stable but high. Interactions between these two kinds of products may have important consequences, especially in the case of widely used medications such as antihypertensives and antibiotics. The aim of this paper is to estimate the prevalence of potentially serious drug–dietary supplement interactions among tetracyclines, thiazides, and angiotensin II receptor blocker users by means of the NHANES 2013–2014 dataset. Methods: Data from 2013–2014 NHANES were obtained. Potential interactions analysed were tetracyclines with calcium, magnesium, and zinc, thiazides with vitamin D, and angiotensin II receptors blockers with potassium. Prevalence was calculated for each potential interaction. Logistic regression was used to assess associated factors. Results: 864 prescriptions issued to 820 patients were analysed. Overall prevalence of potential interaction was 49%. Older age and higher educational level were strongly associated with being at risk of a potential interaction. Factors such as age, race, civil status, citizenship, country of birth, BMI, and physical activity did not show notable associations. Conclusions: Healthcare professionals should be aware of other medical products when they prescribe or dispense a medication or a dietary supplement, especially to the older population and people with a higher educational level.
Modulation of T Regulatory and Dendritic Cell Phenotypes Following Ingestion of Bifidobacterium longum, AHCC® and Azithromycin in Healthy Individuals
Authors: Chowdhury Abeed H. , Cámara Miguel , Verma Chandan , Eremin Oleg , Kulkarni Anil D. , Lobo Dileep N.
Published: October 2019

The probiotic Bifidus BB536 (BB536), which contains Bifidobacterium longum, has been shown to have enhanced probiotic effects when given together with a standardized extract of cultured Lentinula edodes mycelia (AHCC®, Amino Up Co. Ltd., Sapporo, Japan). BB536 and AHCC® may modulate T cell and dendritic cell (DC) phenotypes, and cytokine profiles to favour anti-inflammatory responses following antibiotic ingestion. We tested the hypothesis that orally administered BB536 and/or AHCC®, results in modulation of immune effector cells with polarisation towards anti-inflammatory responses following antibiotic usage. Forty healthy male volunteers divided into 4 equal groups were randomised to receive either placebo, BB536, AHCC® or a combination for 12 days in a double-blind manner. After 7 days volunteers also received 250 mg azithromycin for 5 days. Cytokine profiles from purified CD3+ T cells stimulated with PDB-ionomycin were assessed. CD4+ CD25+ forkhead box P3 (Foxp3) expression and peripheral blood DC subsets were assessed prior to treatment and subsequently at 7 and 13 days. There was no difference in cytokine secretion from stimulated CD3+ T cells between treatment groups. Compared with baseline, Foxp3 expression (0.45 ± 0.1 vs. 1.3 ± 0.4; p = 0.002) and interferon-gamma/interleukin-4 (IFN-γ/IL-4) ratios were increased post-treatment in volunteers receiving BB536 (p = 0.031), although differences between groups were not significant. For volunteers receiving combination BB536 and AHCC®, there was an increase in myeloid dendritic cells (mDC) compared with plasmacytoid DC (pDC) counts (80% vs. 61%; p = 0.006) at post treatment time points. mDC2 phenotypes were more prevalent, compared with baseline, following combination treatment (0.16% vs. 0.05%; p = 0.002). Oral intake of AHCC® and BB536 may modulate T regulatory and DC phenotypes to favour anti-inflammatory responses following antibiotic usage.
Synergistic Effect of a HER2 Targeted Thorium-227 Conjugate in Combination with Olaparib in a BRCA2 Deficient Xenograft Model
Authors: Wickstroem Katrine , Karlsson Jenny , Ellingsen Christine , Cruciani Véronique , Kristian Alexander , Hagemann Urs B. , Bjerke Roger M. , Ryan Olav B. , Linden Lars , Mumberg Dominik , Brands Michael , Cuthbertson Alan
Published: October 2019

Targeted thorium-227 conjugates (TTCs) represent a novel class of therapeutic radiopharmaceuticals for the treatment of cancer. TTCs consist of the alpha particle emitter thorium-227 complexed to a 3,2-hydroxypyridinone chelator conjugated to a tumor-targeting monoclonal antibody. The high energy and short range of the alpha particles induce potent and selective anti-tumor activity driven by the induction of DNA damage in the target cell. Methods: The efficacy of human epidermal growth factor receptor 2 (HER2)-TTC was tested in combination in vitro and in vivo with the poly ADP ribose polymerase (PARP) inhibitor (PARPi), olaparib, in the human colorectal adenocarcinoma isogenic cell line pair DLD-1 and the knockout variant DLD-1 BRCA2 -/- Results: The in vitro combination effects were determined to be synergistic in DLD-1 BRCA2 -/- and additive in DLD-1 parental cell lines. Similarly, the in vivo efficacy of the combination was determined to be synergistic only in the DLD-1 BRCA2 -/- xenograft model, with statistically significant tumor growth inhibition at a single TTC dose of 120 kBq/kg body weight (bw) and 50 mg/kg bw olaparib (daily, i.p. for 4 weeks), demonstrating comparable tumor growth inhibition to a single TTC dose of 600 kBq/kg bw. Conclusions: This study supports the further investigation of DNA damage response inhibitors in combination with TTCs as a new strategy for the effective treatment of mutation-associated cancers.
Characterization and Mapping of a Novel Premature Leaf Senescence Mutant in Common Tobacco (Nicotiana tabacum L.)
Authors: Gao Xiaoming , Wu Xinru , Liu Guanshan , Zhang Zenglin , Chao Jiangtao , Li Zhiyuan , Guo Yongfeng , Sun Yuhe
Published: October 2019

As the last stage of plant development, leaf senescence has a great impact on plant’s life cycle. Genetic manipulation of leaf senescence has been used as an efficient approach in improving the yield and quality of crop plants. Here we describe an ethyl methane sulfonate (EMS) mutagenesis induced premature leaf senescence mutant yellow leaf 1 (yl1) in common tobacco (Nicotiana tabacum L.). The yl1 plants displayed early leaf yellowing. Physiological parameters and marker genes expression indicated that the yl1 phenotype was caused by premature leaf senescence. Genetic analyses indicated that the yl1 phenotype was controlled by a single recessive gene that was subsequently mapped to a specific interval of tobacco linkage group 11 using simple sequence repeat (SSR) markers. Exogenous plant hormone treatments of leaves showed that the yl1 mutant was more sensitive to ethylene and jasmonic acid than the wild type. No similar tobacco premature leaf senescence mutants have been reported. This study laid a foundation for finding the gene controlling the mutation phenotype and revealing the molecular regulation mechanism of tobacco leaf senescence in the next stage.
Conjugated Polymers Containing Building Blocks 1,3,4,6-Tetraarylpyrrolo[3,2-b]pyrrole-2,5-dione (isoDPP), Benzodipyrrolidone (BDP) or Naphthodipyrrolidone (NDP): A Review
Authors: Deng Zhifeng , Ai Taotao , Li Rui , Yuan Wei , Zhang Kaili , Du Huiling , Zhang Haichang
Published: October 2019

π-Conjugated organic donor–acceptor (D–A) type polymers are widely developed and used in electronic device. Among which, diketopyrrolopyrrole (DPP)-based polymers have received the most attention due to their high performances. The novel chromophores named 1,3,4,6-tetraarylpyrrolo[3,2-b]pyrrole-2,5-dione (isoDPP), benzodipyrrolidone (BDP) and naphthodipyrrolidone (NDP) are resemble DPP in chemical structure. IsoDPP is an isomer of DPP, with the switching position of carbonyl and amide units. The cores of BDP and NDP are tri- and tetracyclic, whereas isoDPP is bicyclic. π-Conjugation extension could result polymers with distinct optical, electrochemical and device performance. It is expected that the polymers containing these high-performance electron-deficient pigments are potential in the electronic device applications, and have the potential to be better than the DPP-based ones. IsoDPP, BDP, and NDP based polymers are synthesized since 2011, and have not receive desirable attention. In this work, the synthesis, properties (optical and electrochemical characteristics), electronic device as well as their relationship depending on core-extension or structure subtle optimization have been reviewed. The final goal is to outline a theoretical scaffold for the design the D–A type conjugated polymers, which is potential for high-performance electronic devices.
Brief Overview on Bio-Based Adhesives and Sealants
Authors: Magalhães Solange , Alves Luís , Medronho Bruno , Fonseca Ana C. , Romano Anabela , Coelho Jorge F.J. , Norgren Magnus
Published: October 2019

Adhesives and sealants (AS) are materials with excellent properties, versatility, and simple curing mechanisms, being widely used in different areas ranging from the construction to the medical sectors. Due to the fast-growing demand for petroleum-based products and the consequent negative environmental impact, there is an increasing need to develop novel and more sustainable sources to obtain raw materials (monomers). This reality is particularly relevant for AS industries, which are generally dependent on non-sustainable fossil raw materials. In this respect, biopolymers, such as cellulose, starch, lignin, or proteins, emerge as important alternatives. Nevertheless, substantial improvements and developments are still required in order to simplify the synthetic routes, as well as to improve the biopolymer stability and performance of these new bio-based AS formulations. This environmentally friendly strategy will hopefully lead to the future partial or even total replacement of non-renewable petroleum-based feedstock. In this brief overview, the general features of typical AS are reviewed and critically discussed regarding their drawbacks and advantages. Moreover, the challenges faced by novel and more ecological alternatives, in particular lignocellulose-based solutions, are highlighted.
Data-Driven Robust Optimization for Steam Systems in Ethylene Plants under Uncertainty
Authors: Zhao Liang , Zhong Weimin , Du Wenli
Published: October 2019

In an ethylene plant, steam system provides shaft power to compressors and pumps and heats the process streams. Modeling and optimization of a steam system is a powerful tool to bring benefits and save energy for ethylene plants. However, the uncertainty of device efficiencies and the fluctuation of the process demands cause great difficulties to traditional mathematical programming methods, which could result in suboptimal or infeasible solution. The growing data-driven optimization approaches offer new techniques to eliminate uncertainty in the process system engineering community. A data-driven robust optimization (DDRO) methodology is proposed to deal with uncertainty in the optimization of steam system in an ethylene plant. A hybrid model of extraction–exhausting steam turbine is developed, and its coefficients are considered as uncertain parameters. A deterministic mixed integer linear programming model of the steam system is formulated based on the model of the components to minimize the operating cost of the ethylene plant. The uncertain parameter set of the proposed model is derived from the historical data, and the Dirichlet process mixture model is employed to capture the features for the construction of the uncertainty set. In combination with the derived uncertainty set, a data-driven conic quadratic mixed-integer programming model is reformulated for the optimization of the steam system under uncertainty. An actual case study is utilized to validate the performance of the proposed DDRO method.
Optimization of Microwave Coupled Hot Air Drying for Chinese Yam Using Response Surface Methodology
Authors: Wang Hanyang , Liu Dan , Yu Haiming , Wang Donghai , Li Jun
Published: October 2019

The effect of microwave coupled hot air drying on rehydration ratio (RR) and total sugar content (TSC) of Chinese yam was investigated. Single factor test and response surface methodology were used for process parameter optimization with hot air temperature, hot air velocity, slice thickness, and microwave power density as variables and RR and TSC of dried products as responses. The effect of variables on RR followed the order: slice thickness > hot air temperature > microwave power density > hot air velocity. The effect of variables on TSC followed the order: slice thickness > microwave power density > hot air velocity > hot air temperature. The optimized process parameters were hot air velocity of 2.5 m/s, hot air temperature of 61.7 °C, slice thickness of 8.5 mm, and microwave power density of 5.9 W/g. Under the optimal conditions, the predicted values of RR and TSC were 1.90 g/g and 5.74 g/100 g, respectively, which is very close to corresponding actual values (1.83 g/g and 5.72 g/100 g). The desirability of 0.913 further validated the effectiveness of the model. The findings from this work may apply to other agricultural products.
Chromium VI and Fluoride Competitive Adsorption on Different Soils and By-Products
Authors: Quintáns-Fondo Ana , Ferreira-Coelho Gustavo , Arias-Estévez Manuel , Nóvoa-Muñoz Juan Carlos , Fernández-Calviño David , Álvarez-Rodríguez Esperanza , Fernández-Sanjurjo María J. , Núñez-Delgado Avelino
Published: October 2019

Chromium (as Cr(VI)) and fluoride (F−) are frequently found in effluents from different industrial activities. In cases where these effluents reach soil, it can play an important role in retaining those pollutants. Similarly, different byproducts could act as bio-adsorbents to directly treat polluted waters or to enhance the purging potential of soil. In this work, we used batch-type experiments to study competitive Cr(VI) and F− adsorption in two different soils and several kinds of byproducts. Both soils, as well as mussel shell, oak ash, and hemp waste showed higher adsorption for F−, while pyritic material, pine bark, and sawdust had a higher affinity for Cr(VI). Considering the binary competitive system, a clear competition between both elements in anionic form is shown, with decreases in adsorption of up to 90% for Cr(VI), and of up to 30% for F−. Adsorption results showed better fitting to Freundlich’s than to Langmuir’s model. None of the individual soils or byproducts were able to adsorbing high percentages of both pollutants simultaneously, but it could be highly improved by adding pine bark to increase Cr(VI) adsorption in soils, thus drastically reducing the risks of pollution and deleterious effects on the environment and on public health.
Theoretical and Experimental Insights into the Mechanism for Gas Separation through Nanochannels in 2D Laminar MXene Membranes
Authors: Jin Yun , Fan Yiyi , Meng Xiuxia , Zhang Weimin , Meng Bo , Yang Naitao , Liu Shaomin
Published: October 2019

Clarifying the mechanism for the gas transportation in the emerging 2D materials-based membranes plays an important role on the design and performance optimization. In this work, the corresponding studies were conducted experimentally and theoretically. To this end, we measured the gas permeances of hydrogen and nitrogen from their mixture through the supported MXene lamellar membrane. Knudsen diffusion and molecular sieving through straight and tortuous nanochannels were proposed to elucidate the gas transport mechanism. The average pore diameter of 5.05 Å in straight nanochannels was calculated by linear regression in the Knudsen diffusion model. The activation energy for H2 transport in molecular sieving model was calculated to be 20.54 kJ mol−1. From the model, we can predict that the gas permeance of hydrogen (with smaller kinetic diameter) is contributed from both Knudsen diffusion and molecular sieving mechanism, but the permeance of larger molecular gases like nitrogen is sourced from Knudsen diffusion. The effects of the critical conditions such as temperature, the diffusion pore diameter of structural defects, and the thickness of the prepared MXene lamellar membrane on hydrogen and nitrogen permeance were also investigated to understand the hydrogen permeation difference from Knudsen diffusion and molecular sieving. At room temperature, the total hydrogen permeance was contributed 18% by Knudsen diffusion and 82% by molecular sieving. The modeling results indicate that molecular sieving plays a dominant role in controlling gas selectivity.
A Helical Microrobot with an Optimized Propeller-Shape for Propulsion in Viscoelastic Biological Media
Authors: Li Dandan , Jeong Moonkwang , Oren Eran , Yu Tingting , Qiu Tian
Published: October 2019

One major challenge for microrobots is to penetrate and effectively move through viscoelastic biological tissues. Most existing microrobots can only propel in viscous liquids. Recent advances demonstrate that sub-micron robots can actively penetrate nanoporous biological tissue, such as the vitreous of the eye. However, it is still difficult to propel a micron-sized device through dense biological tissue. Here, we report that a special twisted helical shape together with a high aspect ratio in cross-section permit a microrobot with a diameter of hundreds-of-micrometers to move through mouse liver tissue. The helical microrobot is driven by a rotating magnetic field and localized by ultrasound imaging inside the tissue. The twisted ribbon is made of molybdenum and a sharp tip is chemically etched to generate a higher pressure at the edge of the propeller to break the biopolymeric network of the dense tissue.
Assessing Multiple Years’ Spatial Variability of Crop Yields Using Satellite Vegetation Indices
Authors: Ali Abid , Martelli Roberta , Lupia Flavio , Barbanti Lorenzo
Published: October 2019

Assessing crop yield trends over years is a key step in site specific management, in view of improving the economic and environmental profile of agriculture. This study was conducted in a 11.07 ha area under Mediterranean climate in Northern Italy to evaluate the spatial variability and the relationships between six remotely sensed vegetation indices (VIs) and grain yield (GY) in five consecutive years. A total of 25 satellite (Landsat 5, 7, and 8) images were downloaded during crop growth to obtain the following VIs: Normalized Difference Vegetation Index (NDVI), Enhanced Vegetation Index (EVI), Soil Adjusted Vegetation Index (SAVI), Green Normalized Difference Vegetation Index (GNDVI), Green Chlorophyll Index (GCI), and Simple Ratio (SR). The surveyed crops were durum wheat in 2010, sunflower in 2011, bread wheat in 2012 and 2014, and coriander in 2013. Geo-referenced GY and VI data were used to generate spatial trend maps across the experimental field through geostatistical analysis. Crop stages featuring the best correlations between VIs and GY at the same spatial resolution (30 m) were acknowledged as the best periods for GY prediction. Based on this, 2–4 VIs were selected each year, totalling 15 VIs in the five years with r values with GY between 0.729** and 0.935**. SR and NDVI were most frequently chosen (six and four times, respectively) across stages from mid vegetative to mid reproductive growth. Conversely, SAVI never had correlations high enough to be selected. Correspondence analysis between remote VIs and GY based on quantile ranking in the 126 (30 m size) pixels exhibited a final agreement between 64% and 86%. Therefore, Landsat imagery with its spatial and temporal resolution proved a good potential for estimating final GY over different crops in a rotation, at a relatively small field scale.
A Synergistic Use of a High-Resolution Numerical Weather Prediction Model and High-Resolution Earth Observation Products to Improve Precipitation Forecast
Authors: Lagasio Martina , Parodi Antonio , Pulvirenti Luca , Meroni Agostino , Boni Giorgio , Pierdicca Nazzareno , Marzano Frank , Luini Lorenzo , Venuti Giovanna , Realini Eugenio , Gatti Andrea , Tagliaferro Giulio , Barindelli Stefano , Monti Guarnieri Andrea , Goga Klodiana , Terzo Olivier , Rucci Alessio , Passera Emanuele , Kranzlmueller Dieter , Rommen Bjorn
Published: October 2019

The Mediterranean region is frequently struck by severe rainfall events causing numerous casualties and several million euros of damages every year. Thus, improving the forecast accuracy is a fundamental goal to limit social and economic damages. Numerical Weather Prediction (NWP) models are currently able to produce forecasts at the km scale grid spacing but unreliable surface information and a poor knowledge of the initial state of the atmosphere may produce inaccurate simulations of weather phenomena. The STEAM (SaTellite Earth observation for Atmospheric Modelling) project aims to investigate whether Sentinel satellites constellation weather observation data, in combination with Global Navigation Satellite System (GNSS) observations, can be used to better understand and predict with a higher spatio-temporal resolution the atmospheric phenomena resulting in severe weather events. Two heavy rainfall events that occurred in Italy in the autumn of 2017 are studied—a localized and short-lived event and a long-lived one. By assimilating a wide range of Sentinel and GNSS observations in a state-of-the-art NWP model, it is found that the forecasts benefit the most when the model is provided with information on the wind field and/or the water vapor content.
An Online Method to Detect Urban Computing Outliers via Higher-Order Singular Value Decomposition
Authors: Souza Thiago , Aquino Andre L. L. , Gomes Danielo G.
Published: October 2019

Here we propose an online method to explore the multiway nature of urban spaces data for outlier detection based on higher-order singular value tensor decomposition. Our proposal has two sequential steps: (i) the offline modeling step, where we model the outliers detection problem as a system; and (ii) the online modeling step, where the projection distance of each data vector is decomposed by a multidimensional method as new data arrives and an outlier statistical index is calculated. We used real data gathered and streamed by urban sensors from three cities in Finland, chosen during a continuous time interval: Helsinki, Tuusula, and Lohja. The results showed greater efficiency for the online method of detection of outliers when compared to the offline approach, in terms of accuracy between a range of 8.5% to 10% gain. We observed that online detection of outliers from real-time monitoring through the sliding window becomes a more adequate approach once it achieves better accuracy.
Double-Gap Magnetic Flux Concentrator Design for High-Sensitivity Magnetic Tunnel Junction Sensors
Authors: Hu Jiafei , Ji Minhui , Qiu Weicheng , Pan Long , Li Peisen , Peng Junping , Hu Yueguo , Liu Huiyan , Pan Mengchun
Published: October 2019

To improve the sensitivity of the magnetic tunnel junction(MTJ)sensor, a novel architecture for a double-gap magnetic flux concentrator (MFC) was studied theoretically and experimentally in this paper. The three-dimensional finite element model of magnetic flux was established to optimize the magnetic field amplification factor, with different gaps. The simulation results indicate that the sensitivity of an MTJ sensor with a double-gap MFC can be significantly better than that of a sensor with a traditional single-gap MFC, due to the fact that the magnetic magnification sharply increases with the decrease in effective gap width. Besides this, the half-bridge MTJ sensors with the double-gap MFC were fabricated using photolithography, ion milling, evaporation, and electroplating processes. Experimental results show that the sensitivity of the MTJ sensor increased by ten times compared to the sensor without the double-gap MFC, which underlines the theoretical predictions. Furthermore, there is no significant increase in the sensor noise. The work in this paper contributes to the development of high-performance MTJ sensors.