bluuebunny/crossref_metadata_2025 huggingface dataset:
Total and cause-specific mortality associated with meat intake in a large cohort study in Korea
Authors: Kityo Anthony , Lee Sang-Ah , Kang Daehee
Published: March 2023

Background

Asia has experienced a large increase in meat intake in the past decade, yet the health impact of meat intake is not well studied.

Objective

We examined the association of meat intake with all-cause, cancer and cardiovascular disease (CVD) mortality in an Asian country.

Methods

Participants were 113,568 adults with dietary data at recruitment (2004–2013) of the Health Examinees-Gem (HEXA-G) study, a prospective cohort study conducted in 8 regions of Korea. Participants were followed until 31 December 2020. Total, red, white, and organ meat intake were computed based on a 106-item questionnaire. Multivariable Cox proportional hazard models were implemented using the lowest quintile of meat intake as the reference category.

Findings

For 1,205,236 person-years, 3,454 deaths were recorded. High intake of processed red meat was positively associated with all-cause mortality [men: hazard ratio (HR) 1.21, 95% confidence interval (95% CI) 1.07–1.37; women: HR 1.32, 95% CI 1.12–1.56]. Increased risk of all-cause mortality (HR 1.21, 95% CI 1.05–1.39) and cancer mortality (HR 1.24, 95% CI 1.03–1.50) was observed in women with high intake of organ meat. Moderate intake of pork belly was associated with reduced risk of all-cause mortality in men (HR 0.76, 95% CI 0.62–0.93) and women (HR 0.83, 95% 0.69–0.98) but high intake was associated with increased risk of CVD mortality in women (HR 1.84, 95% CI 1.20–2.82). Low beef intake decreased the risk of CVD mortality in men (HR 0.58, 95% CI 0.40–0.84), but roasted pork increased cancer mortality in women (HR 1.26, 95% CI 1.05–1.52).

Conclusion

There was increased risk of all-cause mortality associated with intake of processed red meat in men and women, increased risk of all-cause and cancer mortality with intake of organ meat in women, and increased risk of cancer mortality with intake of roasted pork intake in women. High intake of pork belly increased the risk of CVD mortality in women, but moderate intake was inversely associated with mortality from all-causes in both men and women.
Analysis of factors influencing the distribution of 131-I in combined treatment of Licartin with transcatheter arterial chemoembolization in primary hepatic carcinoma
Authors: Tang Ming , Li Wen-Liang , Li Jia-Yu , Lv Juan , Chen Fu-Kun , Zhu Jia-Lun , Liu Peng-Jie
Published: March 2023

Objective

To analyze the factors influencing the distribution of 131-I in the liver of patients with advanced hepatic carcinoma treated with the combination of Licartin (131I Metuximab) and transcatheter arterial chemoembolization (TACE). This study provides a reference and basis for the clinic on how to choose the best time for the treatment of Licartin and how to reduce other possible factors affecting the role of Licartin.

Methods

Data from 41 patients with advanced hepatic carcinoma treated with the combination of Licartin and TACE in the Interventional Department of our hospital from March 2014 to December 2020 were collected. This included general characteristics, history of open and interventional surgery, interval between the last interventional surgery and the Licartin treatment, selected arteries in the Licartin perfusion, and 131-I distribution in the liver. Regression analysis was conducted to investigate the factors affecting the distribution of 131I in the liver.

Results

In 14 cases (34.1%), 131-I was evenly distributed in the liver, and there was no correlation between the cause of even distribution with age(OR=0.961, P = 0.939), previous open surgery history(OR=3.547,P= 0.128), previous history of interventional therapy(OR=0.140,P = 0.072), the interval between the last interventional surgery and the Licartin treatment(OR=0.858,P = 0.883), or the choice of the perfusion artery in the Licartin treatment (OR=1.489,P = 0.419). In 14 cases (34.1%), there was higher aggregation in the tumor than in the normal liver, which was related to previous interventional surgery (OR=7.443,P = 0.043). In 13 cases (31.7%), there was lower aggregation in the tumor than in the normal liver, which was related to the selected vessels in the Licartin perfusion (OR=0.23,P = 0.013).

Conclusion

The effective aggregation of 131-I in the liver, even in tumors, the previous history of TACE, and the choice of vessels in the Licartin infusion might be the factors influencing the distribution of 131-I in the liver during hepatic artery infusion of Licartin in combination with TACE therapy.
Development and validation of machine learning models to predict survival of patients with resected stage-III NSCLC
Authors: Jin Long , Zhao Qifan , Fu Shenbo , Cao Fei , Hou Bin , Ma Jia
Published: March 2023

Objective

To compare the performance of three machine learning algorithms with the tumor, node, and metastasis (TNM) staging system in survival prediction and validate the individual adjuvant treatment recommendations plan based on the optimal model.

Methods

In this study, we trained three machine learning madel and validated 3 machine learning survival models-deep learning neural network, random forest and cox proportional hazard model- using the data of patients with stage-al3 NSCLC patients who received resection surgery from the National Cancer Institute Surveillance, Epidemiology, and End Results (SEER) database from 2012 to 2017,the performance of survival predication from all machine learning models were assessed using a concordance index (c-index) and the averaged c-index is utilized for cross-validation. The optimal model was externally validated in an independent cohort from Shaanxi Provincial People’s Hospital. Then we compare the performance of the optimal model and TNM staging system. Finally, we developed a Cloud-based recommendation system for adjuvant therapy to visualize survival curve of each treatment plan and deployed on the internet.

Results

A total of 4617 patients were included in this study. The deep learning network performed more stably and accurately in predicting stage-iii NSCLC resected patients survival than the random survival forest and Cox proportional hazard model on the internal test dataset (C-index=0.834 vs. 0.678 vs. 0.640) and better than TNM staging system (C-index=0.820 vs. 0.650) in the external validation. The individual patient who follow the reference from recommendation system had superior survival compared to those who did not. The predicted 5-year-survival curve for each adjuvant treatment plan could be accessed in the recommender system via the browser.

Conclusion

Deep learning model has several advantages over linear model and random forest model in prognostic predication and treatment recommendations. This novel analytical approach may provide accurate predication on individual survival and treatment recommendations for resected Stage-iii NSCLC patients.
Epiregulin expression and secretion is increased in castration-resistant prostate cancer
Authors: Wiesehöfer Marc , Raczinski Benedikt Bernhard Gereon , Wiesehöfer Caroline , Dankert Jaroslaw Thomas , Czyrnik Elena Dilara , Spahn Martin , Kruithof-de Julio Marianna , Wennemuth Gunther
Published: March 2023

Introduction

In prostate cancer, long-term treatment directed against androgens often leads to the development of metastatic castration-resistant prostate cancer, which is more aggressive and not curatively treatable. Androgen deprivation results in elevated epiregulin expression in LNCaP cells which is a ligand of EGFR. This study aims to reveal the expression and regulation of epiregulin in different prostate cancer stages enabling a more specific molecular characterization of different prostate carcinoma types.

Methods

Five different prostate carcinoma cell lines were used to characterize the epiregulin expression on the RNA and protein levels. Epiregulin expression and its correlation with different patient conditions were further analyzed using clinical prostate cancer tissue samples. Additionally, the regulation of epiregulin biosynthesis was examined at transcriptional, post-transcriptional and release level.

Results

An increased epiregulin secretion is detected in castration-resistant prostate cancer cell lines and prostate cancer tissue samples indicating a correlation of epiregulin expression with tumor recurrence, metastasis and increased grading. Analysis regarding the activity of different transcription factors suggests the involvement of SMAD2/3 in the regulation of epiregulin expression. In addition, miR-19a, -19b, and -20b are involved in post-transcriptional epiregulin regulation. The release of mature epiregulin occurs via proteolytic cleavage by ADAM17, MMP2, and MMP9 which are increased in castration-resistant prostate cancer cells.

Discussion

The results demonstrate epiregulin regulation by different mechanism and suggest a potential role as a diagnostic tool to detect molecular alterations in prostate cancer progression. Additionally, although EGFR inhibitors false in prostate cancer, epiregulin could be a therapeutic target for patients with castration-resistant prostate cancer.
A novel tool to evaluate and quantify radiation pneumonitis: A retrospective analysis of correlation of dosimetric parameters with volume of pneumonia patch
Authors: Huang Jing-Wen , Lin Yi-Hui , Chang Gee-Chen , Chen Jeremy J. W.
Published: March 2023

Introduction

In lung cancer, radiation-induced lung injury (RILI) or radiation pneumonitis (RP) are major concerns after radiotherapy. We investigated the correlation between volumes of RP lesions and their RP grades after radiotherapy.

Methods and materials

We retrospectively collected data from patients with non-small lung cancer that received curative doses to the thorax without undergoing chest radiotherapy before this treatment course. The post-treatment computed tomography (CT) image was used to register to the planning CT to evaluate the correlation between dosimetric parameters and volume of pneumonia patch by using deformable image registration.

Results

From January 1, 2019, to December 30, 2020, 71 patients with non-small cell lung cancer with 169 sets of CT images met our criteria for evaluation. In all patient groups, we found the RPv max and RP grade max to be significant (p<0.001). Some parameters that were related to the dose-volume histogram (DVH) and RP were lung Vx (x=1-66 Gy, percentage of lung volume received ≥x Gy), and mean lung dose. Comparing these parameters of the DVH with RP grade max showed that the mean lung dose and lung V1–V31 were significantly correlated. The cut-off point for the occurrence of symptoms in all patient groups, the RPv max value, was 4.79%, while the area under the curve was 0.779. In the groups with grades 1 and 2 RP, the dose curve of 26 Gy covered ≥80% of RP lesions in >80% of patients. Patients who had radiotherapy in combination with chemotherapy had significantly shorter locoregional progression-free survival (p=0.049) than patients who received radiation therapy in combination with target therapy. Patients with RPv max >4.79% demonstrated better OS (p=0.082).

Conclusion

The percentage of RP lesion volume to total lung volume is a good indicator for quantifying RP. RP lesions can be projected onto the original radiation therapy plan using coverage of the 26 Gy isodose line to determine whether the lesion is RILI.
Prognostic value of pretreatment 18F-FDG PET/CT metabolic parameters in esophageal high-grade neuroendocrine carcinoma: A bicenter retrospective study
Authors: Hou Guozhu , Zhao Ningning , Li Fang , Jing Hongli , Zheng Rong
Published: March 2023

Objective

The aim of this bicentric retrospective study was to assess the prognostic value of 18F-FDG PET/CT in patients with esophageal high-grade neuroendocrine carcinoma (NECs).

Methods

From the database of two centers, 28 patients affected by esophageal high-grade NECs who underwent 18F-FDG PET/CT before treatment were retrospectively reviewed. Metabolic parameters (SUVmax, SUVmean, tumor-to-blood-pool SUV ratio (TBR), tumor-to-liver SUV ratio (TLR), metabolic tumor volume (MTV), total lesion glycolysis (TLG)) of the primary tumor were measured. Univariate and multivariate analyses were performed for progression-free survival (PFS) and overall survival (OS).

Results

After a median follow-up period of 22 months, disease progression occurred in 11 (39.3%) patients, and death occurred in 8 (28.6%) patients. The median PFS was 34 months, and the median OS was not reached. Univariate analyses revealed that among metabolic parameters, only MTV and TLG were significant prognostic factors, while among clinical variables, only distant metastasis was a significant factor for both PFS and OS (P< 0.05). On multivariate analyses, MTV and TLG were independent prognostic factors for both PFS and OS (P< 0.05).

Conclusions

In patients with esophageal high-grade NEC, MTV and TLG measured on pretreatment 18F-FDG PET/CT are independently prognostic factors for predicting PFS and OS, and might be used as quantitative prognostic imaging biomarkers.
Presepsin as a promising biomarker for early detection of post-operative infection in children
Authors: Puspaningtyas Niken Wahyu , Karyanti Mulya Rahma , Paramita Tiara Nien , Sjakti Hikari Ambara , Putri Nina Dwi , Tridjaja Bambang , Yanuarso Piprim Basarah , Rinaldhy Kshetra , Yani Ahmad , Gayatri Pramita
Published: March 2023

Background

Post-operative systemic inflammation response syndrome (SIRS) is an event that results from surgical trauma, white blood cells contact activation, and intra-surgical bacterial translocation, which is difficult to distinguish from sepsis. Presepsin is a novel biomarker that is increased since the early stages of bacterial infection and can be used to confirm the diagnosis of post-operative infectious complications. This study aimed to investigate the diagnostic performance of presepsin for post-operative infectious complications compared to other well-known biomarkers.

Method

This cross-sectional study included 100 post-operative patients admitted to Cipto Mangunkusumo National Hospital and Bunda Hospital in Jakarta, Indonesia. The objective was to identify the optimal cutoff and trend of plasma presepsin concentration on the first and third day after surgery and to compare them with other biomarkers.

Result

Plasma presepsin level was higher in the infection group compared to the non-infection group (median 806.5 pg/ml vs. 717 pg/ml and 980 pg/ml vs. 516 pg/ml on the first and third day, respectively). Presepsin levels tended to increase on the third post-operative day (median + 252 pg/ml) in children with infection. The opposite trend was observed in the non-infection group from the first to the third day (median -222.5 pg/ml). Presepsin delta, a three-day difference between the first and third post-operative day, had the best diagnostic performance compared to other biomarkers (Area Under the Curve 0.825). The optimal cutoff for presepsin delta to diagnose post-operative infection was +90.5 pg/ml.

Conclusion

Serial assessments of presepsin levels on the first and third days post-surgery and their trends are helpful diagnostic markers for clinicians to detect post-operative infectious complications in children.
Construction of a prognostic model for HCC based on ferroptosis-related lncRNAs expression and its potential to predict the response and irAEs of immunotherapy
Authors: Dong Liangbo , Zhou Shengnan , Bai Xuesong , He Xiaodong
Published: March 2023

Background: Ferroptosis is an iron-dependent programmed cell death process, and studies have confirmed that it plays an important regulatory role in the occurrence and development of various malignancies including hepatocellular carcinoma (HCC). In addition, the role of abnormally expressed long non-coding RNAs (lncRNAs) in regulating and driving the occurrence and development of HCC has attracted more and more attention. However, there is still a lack of research on the role of ferroptosis-related lncRNAs in the prognosis prediction of HCC patients.

Method: In this study, we used the Pearson test method to analyze the association between differentially expressed lncRNAs and ferroptosis-related genes in HCC and normal tissues obtained from The Cancer Genome Atlas (TCGA), and found 68 aberrantly expressed and prognosis-related ferroptosis-related lncRNAs. Based on this, we established an HCC prognostic model composed of 12 ferroptosis-related lncRNAs. In addition, HCC patients were divided into a high-risk group and a low-risk group according to the risk score of this 12 ferroptosis-related lncRNAs prognostic model. Gene enrichment analysis indicated that ferroptosis-related lncRNA-based expression signatures may regulate HCC immune microenvironment signaling pathways through ferroptosis, chemical carcinogenesis-reactive oxygen species, and NK cell-mediated cytotoxicity pathways. In addition, immune cell correlation analysis showed that there were significant differences in immune infiltrating cell subtypes, such as Th cells, macrophages, monocytes, and Treg cells between the two groups. In addition, the expression of multiple immune checkpoint molecules was found to be significantly increased in the high-risk group (eg, PD1, CTLA-4, CD86, etc.).

Results: Our research provides a new method for predicting prognosis using a ferroptosis-related lncRNA expression signature prognostic model in hepatocellular carcinoma. And it provides new tools for predicting patient response and adverse effects of immunotherapy.

Conclusion: In conclusion, ferroptosis-related lncRNA expression signatures can be used to construct a prognostic prediction model to predict the overall survival of HCC patients, and can be used as an independent influencing factor for prognosis. Further analysis showed that ferroptosis-related lncRNAs may affect the efficacy of immunotherapy in patients with HCC by altering the tumor microenvironment, so this model may serve as a new indicator of the response and irAEs of HCC to immunotherapy.
Comparative efficacy of 5 sodium-glucose cotransporter protein-2 (SGLT-2) inhibitor and 4 glucagon-like peptide-1 (GLP-1) receptor agonist drugs in non-alcoholic fatty liver disease: A GRADE-assessed systematic review and network meta-analysis of randomized controlled trials
Authors: Gu Yunpeng , Sun Lei , Zhang Wei , Kong Tingting , Zhou Run , He Yining , Deng Chaohua , Yang Luping , Kong Jianing , Chen Yutong , Shi Junping , Hu Yanli
Published: March 2023

Background: The relative efficacy of 5 sodium-glucose cotransporter protein-2 (SGLT-2) inhibitors and 4 glucagon-like peptide-1 (GLP-1) receptor agonists for non-alcoholic fatty liver disease (NAFLD) therapy has not been sufficiently investigated.

Methods: Randomized controlled trials (RCTs) in which patients with NAFLD were treated with SGLT-2 inhibitors or GLP-1 receptor agonists were included. Primary outcomes were improvements in liver enzymes and liver fat parameters, while secondary outcomes included anthropometric measures, blood lipids and glycemic parameters. The frequentist method was used to perform a network meta-analysis. Evidence certainty was assessed using the grading of recommendations assessment, development, and evaluation (GRADE).

Results: The criteria were satisfied by 37 RCTs with 9 interventions (5 SGLT-2 inhibitors and 4 GLP-1 receptor agonists). Based on high certainty evidence, in patients with NAFLD (or comorbid with type 2 diabetes), semaglutide could lower alanine aminotransferase as well as aspartate aminotransferase, γ-glutamyl transferase, controlled attenuation parameter, liver stiffness measurement, body weight, systolic blood pressure, triglycerides, high-density lipoprotein-cholesterol, glycosylated hemoglobin. Liraglutide could lower alanine aminotransferase as well as subcutaneous adipose tissue, body mass index, fasting blood glucose, glycosylated hemoglobin, glucose and homeostasis model assessment, while dapagliflozin could lower alanine aminotransferase as well as body weight, fasting blood glucose, postprandial blood glucose, glycosylated hemoglobin, glucose and homeostasis model assessment.

Conclusion: Semaglutide, liraglutide, and dapagliflozin all have a certain effect on NAFLD (or comorbid with type 2 diabetes) based on high confidence evidence from indirect comparisons, and semaglutide appears to have a therapeutic advantage over the other included medicines. Head-to-head studies are needed to provide more confidence in clinical decision-making.
Incidence, clinical features and risk factors of tacrolimus induced idiosyncratic liver injury in renal transplant recipients: A nested case-control study
Authors: Lv Binbin , Liu Longshan , Liu Xiaoman , Huang Min , Chen Xiao , Tang Kejing , Wang Changxi , Chen Pan
Published: March 2023

Rare data reported tacrolimus-induced liver injury (tac-DILI) in real world. We performed a nested case-control analysis of 1,010 renal transplant recipients. Recipients with tac-DILI were randomly matched at a ratio of 1:4 by the year of admission to the remaining recipients without tac-DILI to explore risk factors. The incidence of tac-DILI was 8.9% (95% CI = 7.2–10.7%). The most common type was cholestatic pattern (6.7%, 95% CI = 5.2–8.3%), followed by hepatocellular (1.6%, 95% CI = 0.8–2.4%) and mixed patterns (0.6%, 95% CI = 0.1–1.1%). 98.9% of recipients with tac-DILI have mild severity. The latency period were 42.0 (range, 21.5–99.8 days), 14.0 (range, 9.0–80.3 days), 16.0 (range, 11.5–24.5 days), and 49.0 days (range, 28.0–105.6 days) for total, hepatocellular, mixed, and cholestatic patterns, respectively. Baseline ALP level (OR = 1.015, 95% CI = 1.006–1.025, p = 0.002), age (OR = 0.971, 95% CI = 0.949–0.994, p = 0.006), and body weight (OR = 0.960, 95% CI = 0.940–0.982, p < 0.001) were independent risk factors. In conclusion, cholestatic pattern represents the most frequent type of tac-DILI. Young age, low body weight and abnormal baseline ALP level were risk factors.
Pune GSH supplementation study: Analyzing longitudinal changes in type 2 diabetic patients using linear mixed-effects models
Authors: Madathil Arjun Kolappurath , Ghaskadbi Saroj , Kalamkar Saurabh , Goel Pranay
Published: March 2023

Oral GSH supplementation along with antidiabetic treatment was shown to restore the body stores of GSH significantly and reduce oxidative DNA damage (8-OHdG) in Indian Type 2 diabetic (T2D) patients over 6 months in our recent clinical study. Post hoc analysis of the data also suggested that elder patients benefit from improved HbA1c and fasting insulin. We modeled longitudinal changes in diabetic individuals using a linear mixed-effects (LME) framework and obtained i) the distribution of individual trajectories with and without GSH supplementation and ii) the overall rates of changes in the different study arms. Serial changes in elder and younger diabetic individuals were also modeled independently to examine differences in their progression. The average linear trajectories obtained from the model explain how biochemical parameters in T2D patients progress over 6 months on GSH supplementation. Model estimates show improvements in erythrocytic GSH of 108 µM per month and a reduction in 8-OHdG at a rate of 18.5 ng/μg DNA per month in T2D patients. GSH replenishes faster in younger people than in the elder. 8-OHdG reduced more rapidly in the elder (24 ng/μg DNA per month) than in younger (12 ng/μg DNA per month) individuals. Interestingly, elder individuals show a substantial reduction in HbA1c (0.1% per month) and increased fasting insulin (0.6 µU/mL per month). Changes in GSH correlate strongly with changes in HbA1c, 8-OHdG, and fasting insulin in the elder cohort. The model estimates strongly suggest it improves the rate of replenishment in erythrocytic GSH stores and reduces oxidative DNA damage. Elder and younger T2D patients respond differently to GSH supplementation: It improves the rate of reduction in HbA1c and increases fasting insulin in elder patients. These model forecasts have clinical implications that aid in personalizing treatment targets for using oral GSH as adjuvant therapy in diabetes.
Optimized cabinet parameters for drying lithium-ion batteries based on coupled fluid–thermal field analysis
Authors: Peng Xuan , Wang Zhaohui , Shen Gang , Yang Yong
Published: March 2023

Hot-airflow desiccation is a commonly applied technique for drying lithium-ion batteries. However, most drying cabinet designs currently suffer from poor efficiency because they evacuate steam by ejecting the hot air in the cabinet to the open air continuously. This can be addressed by closing and opening the cabinet periodically, where the temperature of the heating zone is increased as quickly as possible through internal air recirculation in the closed position, and the steam is ejected with the hot air only during the open period. Nonetheless, drying cabinet designs of this nature have been rarely subjected to numerical analysis based on computational fluid dynamics and heat transfer, and the design factors enhancing the rate of temperature increase during the closed period remain poorly understood. The present work addresses these issues by outlining a detailed numerical approach for simulating the airflow temperature of a drying cabinet during internal air recirculation in its closed position, and the characteristics of the airflow and the temperature distribution in the dryer are evaluated via transient fluid–thermal coupling analysis. The results of the numerical investigation indicate that the heating efficiency is substantially influenced by the inlet airflow velocity, the distance between the trays holding the batteries, and the size of the free space between the front door and the trays. The results demonstrate that the developed model provides a useful means of evaluating and optimizing the heating efficiency of these types of drying cabinets.
Genome size variation and polyploidy prevalence in the genus Eragrostis are associated with the global dispersal in arid area
Authors: Hutang Ge-Ran , Tong Yan , Zhu Xun-Ge , Gao Li-Zhi
Published: March 2023

Background

Biologists have long debated the drivers of the genome size evolution and variation ever since Darwin. Assumptions for the adaptive or maladaptive consequences of the associations between genome sizes and environmental factors have been proposed, but the significance of these hypotheses remains controversial. Eragrostis is a large genus in the grass family and is often used as crop or forage during the dry seasons. The wide range and complex ploidy levels make Eragrostis an excellent model for investigating how the genome size variation and evolution is associated with environmental factors and how these changes can ben interpreted.

Methods

We reconstructed the Eragrostis phylogeny and estimated genome sizes through flow cytometric analyses. Phylogenetic comparative analyses were performed to explore how genome size variation and evolution is related to their climatic niches and geographical ranges. The genome size evolution and environmental factors were examined using different models to study the phylogenetic signal, mode and tempo throughout evolutionary history.

Results

Our results support the monophyly of Eragrostis. The genome sizes in Eragrostis ranged from ~0.66 pg to ~3.80 pg. We found that a moderate phylogenetic conservatism existed in terms of the genome sizes but was absent from environmental factors. In addition, phylogeny-based associations revealed close correlations between genome sizes and precipitation-related variables, indicating that the genome size variation mainly caused by polyploidization may have evolved as an adaptation to various environments in the genus Eragrostis.

Conclusion

This is the first study to take a global perspective on the genome size variation and evolution in the genus Eragrostis. Our results suggest that the adaptation and conservatism are manifested in the genome size variation, allowing the arid species of Eragrostis to spread the xeric area throughout the world.
Profiling of cool-season forage arabinoxylans via a validated HPAEC-PAD method
Authors: Joyce Glenna E. , Kagan Isabelle A. , Flythe Michael D. , Davis Brittany E. , Schendel Rachel R.
Published: March 2023

Cool-season pasture grasses contain arabinoxylans (AX) as their major cell wall hemicellulosic polysaccharide. AX structural differences may influence enzymatic degradability, but this relationship has not been fully explored in the AX from the vegetative tissues of cool-season forages, primarily because only limited AX structural characterization has been performed in pasture grasses. Structural profiling of forage AX is a necessary foundation for future work assessing enzymatic degradability and may also be useful for assessing forage quality and suitability for ruminant feed. The main objective of this study was to optimize and validate a high-performance anion-exchange chromatography with pulsed amperometric detection (HPAEC-PAD) method for the simultaneous quantification of 10 endoxylanase-released xylooligosaccharides (XOS) and arabinoxylan oligosaccharides (AXOS) in cool-season forage cell wall material. The following analytical parameters were determined or optimized: chromatographic separation and retention time (RT), internal standard suitability, working concentration range (CR), limit of detection (LOD), limit of quantification (LOQ), relative response factor (RRF), and quadratic calibration curves. The developed method was used to profile the AX structure of four cool-season grasses commonly grown in pastures (timothy, Phleum pratense L.; perennial ryegrass, Lolium perenne L.; tall fescue, Schedonorus arundinaceus (Schreb.) Dumort.; and Kentucky bluegrass, Poa pratensis L.). In addition, the cell wall monosaccharide and ester-linked hydroxycinnamic acid contents were determined for each grass. The developed method revealed unique structural aspects of the AX structure of these forage grass samples that complemented the results of the cell wall monosaccharide analysis. For example, xylotriose, representing an unsubstituted portion of the AX polysaccharide backbone, was the most abundantly-released oligosaccharide in all the species. Perennial rye samples tended to have greater amounts of released oligosaccharides compared to the other species. This method is ideally suited to monitor structural changes of AX in forages as a result of plant breeding, pasture management, and fermentation of plant material.
Research on the evolution and improvement of China’s shadow education governance policy from the perspective of multiple streams theory
Authors: Xiang Kemi , Liu Jinsi , Chen Xinzhong , Zhang Anlu
Published: March 2023

From a global perspective, after-school tutoring education, also known as shadow education, has developed rapidly since the beginning of this century. However, shadow education has also brought many practical problems, such as the increased burden on parents and children, and the unfairness in education. At present, the Chinese government is vigorously implementing the double reduction policy and has achieved remarkable practical results. This study focuses on the evolution of the government policy of shadow education in China. First, it analyzed the four stages of shadow education governance policy experience: the acquiescent survival stage, the encouraging development stage, the preliminary regulation stage, and the comprehensive rectification stage. Python was used for text mining the policies from different periods and analyzing the focus of the policies in different stages by obtaining high-frequency vocabulary. Then, the multiple streams theory was used to explore the policy evolution process and change mechanism. Finally, relevant recommendations have been discussed to address the gaps in the current shadow education governance policies. The study found that the objectives, scope of adjustment, and protection of rights and interests of China’s shadow education governance policies have undergone significant changes over time. Through the constant interaction and interweaving of the stream of problems, the stream of politics, and the stream of policy, the window of opportunity for policy change was jointly promoted. The innovations of this article mainly include the following: First, the evolution of China’s shadow education governance policies was systematically reviewed using text mining methods to compare the differences of governance policies at different stages and second, multiple streams theory was used as the theoretical framework to analyze the reasons for the focus of shadow education governance policy changes.
Antiphase synchrony increases perceived entitativity and uniqueness: A joint hand-clapping task
Authors: Fujiwara Ken , Nomura Kunihiko , Eto Miki
Published: March 2023

In- and antiphase are the dominant patterns identified in the study of synchrony in relative phases. Many previous studies have focused on in-phase synchrony and compared it to asynchrony, but antiphase synchrony has yet not been the subject of much research attention. The limited findings on antiphase synchrony suggest that its role or nature is unclear or unstable in human interaction. To account for this factor, this study examined the possibility that antiphase synchrony simultaneously induced perceived entitativity and uniqueness. The results of an experiment employing a joint hand-clapping task supported this prediction. Further, the elevated feeling of uniqueness in those who experienced antiphase synchrony may have increased the self-other overlap for those who felt oneness with their partner, but it decreased overlap for those who did not. The theoretical implications for synchrony literature are discussed.
Mental and physical conditions associated with physical inactivity among Farhangian University students during virtual classes: A cross-sectional study
Authors: Homayounnia Firouzjah Morteza , Pourazar Morteza , Kakvandi Saeed Nazari
Published: March 2023

Background

The level of mobility and general health has decreased among students in virtual classes during COVID-19 pandemic. The present cross-sectional study aims to investigate the mental and physical conditions related to inactivity among the students of Farhangian University during the virtual classes.

Methods

This is a cross-sectional study. 475 students (214 females and 261 males) were selected as the statistical sample of the study based on Morgan’s Table from Farhangian University, Iran. The statistical population includes students studying at Farhangian University of Mazandaran province that using Convenience Sampling the sample size based on Morgan’s Table, 475 students consisting of 214 females and 261 males were randomly selected as the statistical sample of the study. The research instruments of this study include International Physical Activity Questionnaire, Saehan Caliper (SH5020), Coopersmith Self-Esteem Scale, Beck Depression Questionnaire, and Nordic Skeletal and Muscular Disorders Questionnaire. For data analysis, independent samplet-test was employed to compare two groups. All analyses were conducted using spss24 software.

Results

With respect to students’ skeletal-muscular disorders, findings proved that both genders suffered physical conditions during virtual classes. The research findings showed that the average weekly activity level among women is 634 Met/min with a standard deviation of ±281, and the average weekly activity level among men is 472 Met/min with a standard deviation of ±231. Fat percentage by gender, men’s average fat percentage is 47.21% (S. D ± 4.74) and women’s average fat percentage is 31.55% (S. D ± 4.37). Also, the self-esteem scores of male and female students were obtained 29.72 and 29.43, respectively, and the difference between the two was considered significant (p< 0.05). On the other hand, 67% (No. 25) of female students and 32% (No. 12) of male students suffered from high depression. Also, based on students’ skeletal-muscular disorders, findings of our study showed that both genders suffered physical conditions during virtual classes.

Conclusion

This study suggests increasing the level of physical activity to reduce body fat mass, increase mental health and reduce skeletal disorders, which can be properly accomplished through university planning and prioritizing the health of male and female students.
“Sorry, I’m not from here!”: Female international student-athletes’ transitions into college athletics in the United States
Authors: Swim Nicholas , Lee Youngjik , Hums Mary A.
Published: March 2023

The number of NCAA international student-athletes (ISAs) on US college campuses has increased to upwards of 20,000. This current study sought to investigate their transition experiences into colleges, based on the ISA transition adjustment model. More specifically, this study sought to better understand how recent changes in the NCAA have impacted the ISA population and if the antecedent factors in the transition adjustment model (personal, inter-personal, perceptual, and cultural distance) still represent the best indicators of successful transition for ISAs. To conduct this study, semi-structured interviews were completed with 10 current and former female Division I ISAs from six separate schools and seven countries. The results from this study suggest the core antecedents of the model – personal, inter-personal, perceptual, and cultural distance – were all still relevant. However, the factors included among these antecedents have shifted over time, with this study finding the importance of faculty and students (inter-personal) and nutrition (cultural distance) as significant factors in the transition of ISAs into US colleges. The results provide insights to administrators of US college athletics regarding how to help international student-athletes’ adaptation.
The impact of entrepreneurial team psychological capital on innovation performance: The mediating role of knowledge sharing and knowledge hiding
Authors: Chen Minling , Mi XueMei , Xue Jing , Li Yi , Shi Junran
Published: March 2023

Introduction

The important role of psychological capital on corporate innovation has attracted the attention of academics, more and more scholars have conducted related studies. Although most scholars have explored the mechanisms and paths of psychological capital on innovation performance, few scholars have explored the inner relationship between them from the perspective of knowledge management. Based on the knowledge management perspective, We explore the influence effect of the psychological capital of entrepreneurial teams on the innovation performance of startups in the entrepreneurial situation.

Methods

We conducted hypothesis testing using data from 113 Chinese entrepreneurial teams, and conducted reliability analysis, correlation analysis, and regression analysis on the questionnaire data with the help of SPSS software and AMOS software.

Results

The results showed that (1) entrepreneurial team psychological capital has a significant positive effect on innovation performance of startups; (2) entrepreneurial team psychological capital positively promotes their knowledge sharing behavior and reduces knowledge hiding behavior; (3) entrepreneurial team knowledge sharing and knowledge hiding play a partially mediating role between entrepreneurial team psychological capital and innovation performance of startups; (4)organizational innovation climate plays a moderating role in the influence of entrepreneurial team knowledge sharing and knowledge hiding on the innovation performance of startups.

Discussion

The findings are consistent with the hypothesis model proposed in this paper, indicating that as the psychological capital of entrepreneurial teams increases, the innovation performance of startups can benefit from higher levels of knowledge sharing and lower levels of knowledge hiding.
The path between socioeconomic inequality and cognitive function: A mediation analysis based on the HAALSI cohort in rural South Africa
Authors: Mutola Sianga , Gómez-Olivé F. Xavier , Ng Nawi
Published: March 2023

Background

Socioeconomic position (SEP) strongly predicts late-life cognitive health, yet the pathways between SEP and cognitive function remain unclear. This study assessed whether and to what extent the association between SEP and cognitive function in the adult population in rural South Africa is mediated by some health conditions, behavioral factors, and social capital factors.

Methods

In this cross-sectional study, we used data from the 2014–15 “Health and Aging Africa: A Longitudinal Study of an INDEPTH Community in South Africa” (HAALSI) cohort, including 5,059 adults aged 40+ years from the Agincourt sub-district in Mpumalanga Province, South Africa. SEP, the independent variable, was measured based on ownership of household goods. Cognitive function, the dependent variable, was assessed using questions related to time orientation and immediate and delayed word recall. We used the multiple-mediation analysis on 4125 individuals with complete values on all variables to assess the mediating roles of health conditions (hypertension, diabetes, obesity, and disability), behavioral factors (leisure physical activity, alcohol consumption, and tobacco smoking), and social capital factors (community's willingness to help, trust, sense of safety, and social network contact) in the association between SEP and cognitive function.

Results

Compared to adults in the poorest wealth quintile, those in the richest wealth quintile had better cognition (β = 0.903, p < 0.001). The mediation analysis revealed that health conditions mediated 20.7% of the total effect of SEP on cognitive function. In comparison, 3.3% was mediated by behavioral factors and only 0.7% by social capital factors. In the multiple-mediator model, 17.9% of the effect of SEP on cognitive function was jointly mediated by health conditions, behavioral factors, and social capital factors.

Conclusion

Low socioeconomic position is a significant factor associated with poor cognitive function among adults aged 40 years and above in South Africa. Health conditions mainly mediate the effects between SEP and cognitive function. Therefore, actions to prevent and control chronic health conditions can serve as the entry point for intervention to prevent poor cognitive function among people with low socioeconomic status.
The influence of natural environment in residential areas on subjective well-being of the elderly
Authors: Li Zhen , Jiang Yi , Jin Ziyang , Pu Yiran , Li Hao
Published: March 2023

Objectives

The aim of this study is to explore the relationship between the natural environment of residential areas and the subjective wellbeing of the elderly and the role of elderly's evaluation of the government's environmental protection work in both.

Methods

Based on the China Social Survey Database in 2013, 2015, 2017, 2019, Stata were used to process the data screened according to the restricted conditions. Ordered Probit Model and Sobel were used to test the effect relationship among the variables.

Results

The subjective wellbeing of the elderly is roughly increasing. The natural environment of the living area has a significant positive effect on the subjective wellbeing of the elderly. The evaluation of the elderly on the government's environmental protection work has a positive impact on the elderly's subjective wellbeing similarly and plays an increasingly important intermediary role in the impact of the natural environment in the residential area on the elderly's subjective wellbeing.

Conclusion

To improve the subjective wellbeing of the elderly, the government should continue to play a leading role in coordinating environmental protection and pollution control, strengthen publicity of environmental protection work. Moreover, improve the residential environment governance and protection system oriented by the elderly's evaluation of the government's environmental protection work.
Poor adherence to antiretroviral therapy among adult people living with HIV initiated during the COVID-19 epidemic waves – observations at the University Teaching Hospital in Lusaka, Zambia
Authors: Kafwanka Powell , Nalule Flavia Muyinza , Michelo Charles
Published: March 2023

Background

Coronavirus disease 2019 (COVID-19)-related disruptions in healthcare services and clinical outcomes have been predicted and documented. However, little is known about how antiretroviral therapy (ART) adherence disruptions caused by the COVID-19 pandemic have manifested amidst the ‘Undetectable = Untransmittable' campaign initiative. Using a patient's viral load as a proxy for medication adherence, our study aimed to determine the adherence to ART on first-line medications among adult people living with human immunodeficiency virus (PLWHIV) at the University Teaching Hospital in Lusaka, Zambia during the pandemic.

Methods

This was a hospital-based cross-sectional study. Secondary data of PLWHIV registered to receive ART from the Adult Infectious Disease Centre was extracted from the SmartCare® electronic health record system to constitute a resultant data set that this study used. The data extraction form was used to extract values of dependent (ART adherence measured by viral load detectability) and independent variables and imported them into the statistical analysis tool, STATA version 16.1 MP. Descriptive statistics of individual characteristics, testing for associations using Pearson's chi-square test, and stratified and combined multivariable logistic regression were performed.

Results

Of the 7,281 adult PLWHIV included in this study, 9.0% (95% CI 8.3–9.6%) were virally detectable. Estimates of the odds ratios of detectable viral load remained significantly higher among adult PLWHIV who were initiated on ART after the U=U campaign was launched in Zambia and were on a monthly 2.51 (1.31–9.03) or 6-monthly 4.75 (3.52–6.41) dispensing of a dolutegravir-based regimen and those on 6-monthly dispensing of an efavirenz-based regimen 4.67 (2.16–10.08) compared to their counterparts. Overall estimates showed us the same picture 4.14 (3.22–5.31), having adjusted for all other predictor variables.

Conclusion

We found that a high proportion of people with detectable viral load in the study population, irrespective of medication refill interval and type of regimen, was concentrated among adult PLWHIV who started treatment during the COVID-19 epidemic waves, as compared to those who started treatment before the pandemic. This observed disparity suggests the inherent impact of the pandemic on the adherence to ART among adult PLWHIV in Lusaka, Zambia. This further illustrates how exposed program responses are to external shocks, especially in already weakened health systems, and the need to create program response buffers and resilient program-specific strategies to minimize the effect of external disruptions.