bluuebunny/crossref_metadata_2025 huggingface dataset:
Validating Automatic Concept-Based Explanations for AI-Based Digital Histopathology
Authors: Sauter Daniel , Lodde Georg , Nensa Felix , Schadendorf Dirk , Livingstone Elisabeth , Kukuk Markus
Published: July 2022

Digital histopathology poses several challenges such as label noise, class imbalance, limited availability of labelled data, and several latent biases to deep learning, negatively influencing transparency, reproducibility, and classification performance. In particular, biases are well known to cause poor generalization. Proposed tools from explainable artificial intelligence (XAI), bias detection, and bias discovery suffer from technical challenges, complexity, unintuitive usage, inherent biases, or a semantic gap. A promising XAI method, not studied in the context of digital histopathology is automated concept-based explanation (ACE). It automatically extracts visual concepts from image data. Our objective is to evaluate ACE’s technical validity following design science principals and to compare it to Guided Gradient-weighted Class Activation Mapping (Grad-CAM), a conventional pixel-wise explanation method. To that extent, we created and studied five convolutional neural networks (CNNs) in four different skin cancer settings. Our results demonstrate that ACE is a valid tool for gaining insights into the decision process of histopathological CNNs that can go beyond explanations from the control method. ACE validly visualized a class sampling ratio bias, measurement bias, sampling bias, and class-correlated bias. Furthermore, the complementary use with Guided Grad-CAM offers several benefits. Finally, we propose practical solutions for several technical challenges. In contradiction to results from the literature, we noticed lower intuitiveness in some dermatopathology scenarios as compared to concept-based explanations on real-world images.
Accurate Signal Conditioning for Pulsed-Current Synchronous Measurements
Authors: Pettinato Sara , Girolami Marco , Rossi Maria Cristina , Salvatori Stefano
Published: July 2022

This paper describes a compact electronic system employing a synchronous demodulation measurement method for the acquisition of pulsed-current signals. The fabricated prototype shows superior performance in terms of signal-to-noise ratio in comparison to conventional instrumentation performing free-running measurements, especially when extremely narrow pulses are concerned. It shows a reading error around 0.1% independently of the signal duty cycle (D) in the investigated D = 10−4–10−3 range. Conversely, high-precision electrometers display reading errors as high as 30% for a D = 10−4, which reduces to less than 1% only for D > 3 × 10−3. Field tests demonstrate that the developed front-end/readout electronics is particularly effective when coupled to dosimeters irradiated with the X-rays sourced by a medical linear accelerator. Therefore, it may surely be exploited for the real-time monitoring of the dosimeter output current, as required in modern radiotherapy techniques employing ultra-narrow pulses of high-energy photons or nuclear particles.
Machine Learning Methods for Hypercholesterolemia Long-Term Risk Prediction
Authors: Dritsas Elias , Trigka Maria
Published: July 2022

Cholesterol is a waxy substance found in blood lipids. Its role in the human body is helpful in the process of producing new cells as long as it is at a healthy level. When cholesterol exceeds the permissible limits, it works the opposite, causing serious heart health problems. When a person has high cholesterol (hypercholesterolemia), the blood vessels are blocked by fats, and thus, circulation through the arteries becomes difficult. The heart does not receive the oxygen it needs, and the risk of heart attack increases. Nowadays, machine learning (ML) has gained special interest from physicians, medical centers and healthcare providers due to its key capabilities in health-related issues, such as risk prediction, prognosis, treatment and management of various conditions. In this article, a supervised ML methodology is outlined whose main objective is to create risk prediction tools with high efficiency for hypercholesterolemia occurrence. Specifically, a data understanding analysis is conducted to explore the features association and importance to hypercholesterolemia. These factors are utilized to train and test several ML models to find the most efficient for our purpose. For the evaluation of the ML models, precision, recall, accuracy, F-measure, and AUC metrics have been taken into consideration. The derived results highlighted Soft Voting with Rotation and Random Forest trees as base models, which achieved better performance in comparison to the other models with an AUC of 94.5%, precision of 92%, recall of 91.8%, F-measure of 91.7% and an accuracy equal to 91.75%.
A Scheduling Scheme for Improving the Performance and Security of MU-MIMO Systems
Authors: Carvajal Henry , Orozco Nathaly , Cacuango Stalin , Salazar Paola , Rosero Edgar , Almeida Fernando
Published: July 2022

For the receiver of multiple-input multiple-output (MIMO) systems, linear detectors are an interesting option due to their good performance and low complexity. Nevertheless, MIMO systems lose diversity in exchange for eliminating interference when linear detectors are used. Aiming to maintain the system diversity while mitigating interference between users, this work proposes a scheduling scheme for the uplink of multiuser MIMO (MU-MIMO) systems that employ A antennas and the zero-forcing (ZF) detector at the receiver in the base station (BS). The channel model includes Rician fading and additive white Gaussian noise (AWGN) in an imperfect channel estimation scenario. The proposed scheme selects U users from a group of Ut users to transmit simultaneously, so that the signal-to-noise ratio (SNR) is maximized. For this, an exact expression to evaluate the SNR of the users is obtained. With this result, the scheduling strategy is proposed. Results show that as Ut increases, the outage probability (OP), and the bit error rate (BER) decrease as the system diversity increases, even when the system is completely loaded, i.e., when U=A. Moreover, it is shown that the scheduling scheme counteracts the imperfect channel estimation effects as Ut increases. Finally, the proposed scheme is tested in presence of an external eavesdropper trying to decode the information sent by the users. The results show that the presented proposal allows for a reduction of the secrecy-outage-probability (SOP) as Ut increases.
Development of direct acoustic energy flow analysis (DAEFA) for ship cabin noise in the medium-to-high frequency range
Authors: Kim Tae-Gyoung , Hong Suk-Yoon , Song Jee-Hun , Kwon Hyun-Wung , Kim Sung-Hooin
Published: July 2022

Noise analysis from heating, ventilation and air conditioning (HVAC) elements in ship cabins is needed to satisfy the strict noise regulation for the ship cabin, and it is very important for their effects to be evaluated in the early stage of design. In this paper, a direct acoustic
energy flow analysis (DAEFA) model is presented for the noise analysis of the ship cabin to reflect direct fields of the sources from an HVAC element. Total acoustic fields are considered by deriving the fundamental solution of the energy flow model for direct and reverberant fields in a closed
space. Sound propagation in the direct field is implemented using the geometrical acoustics concept, and noise sources introduced into the reverberant sound fields are considered by using the relationship between direct fields and the closed space boundaries. For cabin noise analysis using
DAEFA, interior boundaries of the cabin are discretized, and boundary integral formulations for each field are integrated. Noise analysis is performed for various cases with the DAEFA model to minimize cabin noise. The optimal design derived through the analysis was applied to an actual ship,
and cabin noise measurement was conducted onboard the applied ship. Comparison of the analysis and measurement results confirms the effectiveness of the proposed design.
Dynamic force measurement to assess NVH performance of electric motors
Authors: He Song , Omell William , Gandham Michael
Published: July 2022

The electromagnetic (EM) force induced motor whine is a major noise source of hybrid and electric vehicles. Experimental quantification of dynamic EM force is highly desirable to assess the NVH performance of electric motors. However, it is difficult to measure EM forces directly on
the stator teeth. This paper describes a new indirect method to measure the dynamic forces at stator mounting ear locations. First, high-precision tri-axial piezoelectric force ring sensors are selected and calibrated to measure dynamic forces under compressive mean loading. Next, special
motor housings are designed and built to accommodate force sensors between the stator ears and the base mounting plate. Force sensors are then aligned with the stator circumferential directions to measure dynamic forces in radial, tangential and axial directions as a function of motor torque
and speed. The new technology is successfully implemented for electric motors of GM's Spark and Bolt EVs. Measured dynamic forces correlate well with finite-element analytical results and show consistent trends with noise and vibration responses. This confirms the dynamic mounting force can
be used as an effective and measurable indicator to optimize NVH designs for electric motors.
Acoustic measurement practices for UAS and UAM
Authors: Josephson David
Published: July 2022

Characterization of noise emission from novel aircraft types such as UAS and UAM is important for assessment of their impact on community soundscapes. Critical planning decisions such as the required buffer area between vertiports and noise-sensitive land uses will be made based on
levels of interference with human activity. Traditional methods developed for fixed wing aircraft and helicopters may not be sufficient, because the sound character of UAS/UAM can make them more or less audible than their traditionally measured noise magnitude would suggest. Techniques have
been developed that enable assessment of steady and time-varying loudness, tone prominence, sound quality and other metrics by adopting consistent calibrated procedures for acoustic waveform capture along with relevant metadata. This presentation will explore field procedures and data reduction
employed to facilitate reconstruction of the aircraft sound at any receiver point on the ground, and subsequent application of existing or new metrics to this data.
Panel contribution analysis combined with scale modeling for assessing equipment noise
Authors: Herrin D. W. , Cheng Gong
Published: July 2022

A combination of panel contribution analysis and scale modeling can be used to predict acoustic emissions of equipment prior to siting. Moreover, attenuation strategies like constructing barriers and adding absorption can be assessed prior to installing the equipment. The panel contribution
analysis procedure is described, and the acoustic scale modeling rules are summarized. The procedure is then illustrated in two applications: a) predicting acoustic emissions from a generator set and b) determining acoustic emissions from air handlers in a bakery. In both cases, barrier treatments
were considered, and the procedure was successful in identifying the resulting attenuation.
Advancing support for cause-and-effect models by estimating the kurtosis statistic using fractional-octave-band filters
Authors: Zechmann Edward
Published: July 2022

This paper presents a preliminary method for estimating signal processing parameters that optimally satisfies accuracy and resolution requirements for the sound pressure level and kurtosis level. The kurtosis statistic has long been studied and more recently used for applications in
acoustics and vibrations such as architectural acoustics, hearing loss, noise exposure, and accelerated material and structural life testing. The temporal and spectral characteristics of many quantities are evident by time-frequency analysis including hearing, finger sensation, sound diffusion,
and reverberation. Some research has conditioned on frequency content while other research has not. Simpson's reversal may potentially adversely affect the models if frequency content is not considered. Modeling techniques which relate cause-and-effect are more likely to result in successful
models. Models of human hearing are particularly sensitive to the frequency content because the tonotopic organization of the cochlea induces a cause-and-effect relationship from sound incident on the ear to the basilar membrane. The fractional-octave-band filters specified in ANSI S1.11 and
IEC 61260-1 are well developed for conditioning on frequency bands. This paper provides details of the process for optimizing the filter parameters. Additional optimization and testing is described for developing a faster and more accurate method with better support for causal inference.
Measurements of train vibration impacts on vibration sensitive facilities
Authors: Xiong Blong
Published: July 2022

In this paper, measurements of train vibration impacts on vibration sensitive facilities are presented. Some of these measurements were carried out in the planning phases to evaluate the suitability of potential sites. In some cases, measurements were carried out post-construction to
verify the effectiveness of mitigation measures. Data will be presented showing typical setback distances required to meet the most stringent vibration design criteria for sensitive facilities. For cases where specific setback distances might not be achievable, mitigation measures are introduced
with supporting data of the effectiveness of those measures (where available). The collection of data presented shows that the most sensitive vibration criteria often require very large setback distances (> 1000ft). However, utilizing careful building design and placement of sensitive instruments
below grade can allow achieving those criteria at much closer distances within those setback zones.
Auralizing comparable structural vibration measurements to inform design decisions
Authors: Strong John , Springthorpe Christopher
Published: July 2022

The design challenges presented by locating high-impact noise-producing athletic spaces, such as weight rooms and gymnasia adjacent to other occupied spaces are compounded by the difficulty in conveying the resulting experience through narratives or numeric performance criteria. As
auralization tools can very effectively convey experiences in room acoustics and sound isolation, that effectiveness prompted an exploration into its possible use for conveying the experiences of impact-induced noise transfer resulting from difficult adjacencies. However, realistic and accurate
auralization of a structural vibration path offers far more complex challenges than typical auralizations. For example, structural modeling for building design typically does not reach the resolution required for auralizations, if performed at all. Performance data for comparative floor types
typically use tapping machines to comply with the Impact Isolation Class (IIC), which does not represent the response low-frequency content induced by heavy impacts. This paper dissects a case study of a method developed to address these challenges presenting a comparative auralization between
athletic and gymnasium floor underlayment systems, enabling a client to experience the relative differences to aid design decisions. This included a method of presenting structural vibration with realistic source noise components and room effects to achieve a full soundscape.
A possible mitigation measures for urbanized residential care homes for elderly (RCHE) - acoustic window with natural ventilation
Authors: Lam Man Sum , Kwok May Hang Grace , Cheung Siu Ming , Ng Joanne Wai Yin , Tang Wing Yee
Published: July 2022

Hong Kong is well known as a densely populated city, which has an explicit usage of road traffic as its transport backbone. Severe road traffic noise problem is resulted from poorly planning in past decades, leads to the development of typical baffle type acoustic window with only one
outer and one inner opening to attenuate adverse traffic noise impact. Nevertheless, extensive noise mitigation measures while allowing natural ventilation are essential when designing a RCHE. In view of the concern of the limited accessibility of the elderlies, the equal opportunity at both
sides of the room to meet the needs of accessing to openable window was taken into account as far as possible. The proposed outer opening of the specially designed acoustic window is located in the middle, while the respective inner openings are located at the 2 sides. In this paper, mock-up
test were carried out to analyze the acoustic performance of the specially designed acoustic window with two inner opening against the special characteristics of road traffic noise. Test results shown that the specially designed acoustic window is effective in mitigating substantial road traffic
noise while providing reasonably amount of ventilation.
Alternative to resilient channel
Authors: Herreman Kevin , Taylor Corey
Published: July 2022

Managing vibro-acoustic energy transfer between spaces has traditionally relied upon resilient channel to achieve acceptable isolation between spaces. Resilient channel is very sensitive to installation errors requiring well trained and skilled installers. Even then results can be compromised
by any connection to the wall framing. Beyond the added cost of the resilient channel , the wall thickness increases by at least one-half inch and up to one and a quarter inches depending on the remediation required which effects door, window, and fixture installations. Leveraging the fundamental
learnings of studying the vibro-acoustic energy transfer mechanism in partition walls, an alternative approach for acoustic isolation for partition walls was determined. A study of performance based on design parameters allowed the design and development of a material solution. The resulting
performance and comparative results will be presented.
Studying footfall vibration criteria in a changing market and the effects on structural design
Authors: Ormsbee Caitlin
Published: July 2022

Design parameters for vibration criteria and tolerances from footfall induced vibration have long been categorized by general use with a focus on human comfort, with guidelines for offices, residential uses and hospital patient rooms. More stringent criteria required for sensitive laboratory
and research equipment has typically been limited to select locations within projects. As the life science industry continues to expand, there is a growing trend to provide a leasable core & shell space that is already suitable for these more stringent equipment requirements while maintaining
flexibility within the building. This paper reviews how 3D modelling can be utilized to demonstrate the expected vibration in large structures and study various iterations to determine how steel depth, steel weight, and composite structures can reduce vibration levels across the floorplate.
Also discussed will be the implications of changing the structural design goals, with project examples of how other design considerations such as ceiling height, cost, and project schedules are impacted.
Establishing the appropriate maximum sound pressure levels in absence of a noise ordinance for a residential community near an indoor firing range.
Authors: Bartus II Mark , Babich Jeffrey
Published: July 2022

Environmental noise surveys assess the ambient noise levels of a specific area, as well as any noise sources deemed inappropriate for the noise environment. Recently, an environmental noise survey was completed to understand the impact of an indoor firing range on adjacent residential
properties. Because of the transient nature of the gunfire, day-night equivalent sound pressure level (Ldn), a standard found often in community noise ordinances, was deemed an inappropriate metric to truly determine the intrusiveness of the noise on the surrounding environment. Rather, fast-response
maximum sound pressure levels (Lmax) were captured and analyzed in their relation to ambient background noise levels for their effectiveness in translating the impact of the gunfire on adjacent residential properties. Furthermore, multiple frequency-weighting filters were applied to these
measurements to fully understand the characteristics of this broadband, high-impact noise. This paper discusses the appropriateness of Lmax when focusing on transient environmental noise levels caused by an indoor firing range as well as how these metrics should be characterized in community
noise ordinances.
Controling noise from tunnel ventilation fans
Authors: Peterman Karl , LaForgia Dan
Published: July 2022

Infrastructure projects involving transportation networks underground such as railways and roadways have strict ventilation requirements for fire and smoke and engine exhaust control. The fans used for these projects are often very large and very loud compared to typical building equipment.
Transit autorities typically have criteria regarding A-weighted decibel levels in and around the tunnel environment to ensure audibilty of emergency announcements and acceptablility of environmental sound levels. Fan and duct silencers as well as acoustical panels play critical roles in meeting
maximum sound level criteria at property lines and at track and platform levels. Due to high airflow rates, the design, placement, and configuration of noise control products must be carefully considered to ensure adequate system performance. This paper will review various issues and considerations
encountered in tunnel ventilation noise control projects and present typical solutions and design practices with examples.
Acoustical impacts on hard disk drive dynamics
Authors: Oppenheimer Charles , Peterson Chris
Published: July 2022

Acoustical output from air movers in computing systems can reach sufficiently high sound pressure levels and in frequency bands such that performance of Hard Disk Drives (HDD) is degraded. In this paper air mover acoustical characteristics and comparisons to standalone measurements
and models relevant to the performance issues are explored. Sound pressure levels, frequency bands, directivity, and explicit source descriptions are considered for air mover sources, and duct transmission, statistical energy, acoustic diffusion, and measured transfer factors are considered
for noise transmission along acoustic path(s) from air mover to HDD within computing systems.
The application of frequency response function methods along with heavy/hard force pulse data in the mitigation of fitness activities
Authors: Brush Ethan , Golden Matthew
Published: July 2022

Previous work by Golden and others have shown that a specialized drop tower measurement setup can be used to repeatedly test fitness flooring performance in a controlled environment. Such measurements provide a force time history for heavy weights dropped onto various flooring assemblies.
This data has been shared with the community, and accurate predictions of vibration to receiver spaces has been achieved using frequency response function (FRF) methods. This process has been used in the mitigation or evaluation of excessive vibration concerns in buildings with fitness centers
that allow heavy weight drops. This paper discusses mitigation examples using the FRF and force pulse method that include fitness flooring only, building structural modifications, as well as special "floating floors" that incorporate an isolated inertia base.
Tire test stand measurements for blocked forces identification and tire noise auralization
Authors: Hadjit Rabah , Engels Bret , Brandstetter Markus , Poulos Athanasios
Published: July 2022

Tire/Road noise is a dominant contribution to a vehicle interior noise. In this paper, we present the process we developed to support automotive OEMs with road noise engineering during vehicle design and development. The process uses blocked forces identified from measurements performed
on a single tire installed on a test stand. The forces are then combined with vehicle level transfer functions to predict the sound at the driver ears. The results are imported in a driving simulator for NVH to allow for auralization and sound quality evaluations. The process can be applied
from the very early stages of the vehicle development using CAE simulation results and allows to evaluate the vehicle road noise performance long before the first prototype is available.
Hydraulic source ripple and source impedance in 3D acoustic FEM model
Authors: Hua Xin , Patel Pratik , Tuyls Zachary
Published: July 2022

Pressure ripple, fluid-borne acoustic pressure wave, can be critical in hydraulic system design. Hydraulic pumps can be considered as an acoustic source causing pressure ripple. And thus, acoustic modeling approaches are appropriate to simulate pressure ripple in the system. Acoustic
source characteristics include source strength and source impedance below the plane wave cutoff frequency. They can not only be used to analytical model straightforwardly, but also be applied in a 3D acoustic model with proper setup. This paper demonstrates how source characteristics of hydraulic
pumps be applied in finite element models. The proposed method is validated by comparing to a 1-D analytical model, and then a case study demonstrates how the source characteristics can assist on pressure ripple design of the system. The method can also be translated to applications other
than hydraulic systems, like engine intakes, exhaust systems, and HVAC systems.
An angle-error model for enveloping surface sound power measurements
Authors: Bard Seth
Published: July 2022

Free-field sound power measurement methods based on enveloping surfaces, namely ISO 3744 and ISO 3745, contain an inherent source of measurement inaccuracy associated with the angle between the vector normal to the measurement surface and the intensity vector of the incident sound wave.
Instead of using the normal component of the intensity vector in the sound power computation, only the magnitude is considered. The standards broadly acknowledge the uncertainty, but they do not offer an implementable solution to correct for the bias of this angle error. The multivariate nature
of the angle error as a function of one or more sources, receivers, and methods, each of which with their own unique definitions, complicates the ability to calculate and correct the error for any sound power measurement. This paper applies a computational approach based on a ray-tracing model
of a point source and its image source to calculate the angle error associated with standardized free-field sound power measurement methods for various enveloping surfaces. Simplifying assumptions are leveraged to generate a model of the angle error over a range of enveloping surface measurement
scenarios.
Traffic noise reduction attributed to roadside vegetation: ohio case study
Authors: Sperry Ben , Myers Elizabeth , Maracz Sarah , Rochat Judy , Cubick Karel
Published: July 2022

This paper reports the findings of a research study which examined the noise reduction associated with roadside vegetation. A case study location along a major freeway in Columbus, Ohio, was utilized. Noise measurements were obtained at two locations in a neighborhood adjacent to the
freeway. The neighborhood was partially shielded from the freeway by a stand of bushes and trees typical of roadside vegetation in Ohio. One location with high-density vegetation was completely shielded from the freeway while the second had lower-density vegetation with some direct line-of-sight
downstream of the position. Noise measurements at the site were conducted in September 2019 on an average weekday under typical meteorological conditions for the region. Measurements were obtained simultaneously at each position to permit direct comparison of the noise reduction. Analysis
indicated that the noise reduction attributed to the vegetation was approximately 3.0 dBA with an additional 1.0 dBA of reduction at the high-density position. Models of the site using FHWA TNM indicated that the modeled noise reduction was lower than what was measured in the field. The results
of this case study add the body of knowledge on the topic of traffic noise reduction attributed to the presence of roadside vegetation.
A novel multi-gradient direction FxLMS algorithm with output constraint for active noise control
Authors: Cheng Yabing , Ge Pingyu , Chen Shuming , Li Chao , Jiang Yao
Published: July 2022

In active noise control (ANC) system, the maximum output power is restricted by the actuator drive performance. In the case that the output signal power exceeds this limitation, the noise reduction performance of the ANC system will be deteriorated due to the inherent nonlinearity of
the actuators, and the adaptive algorithm also will be degraded. Therefore, a multi-gradient direction filtered-x least mean square (MGD-FxLMS) algorithm with output constraint is presented. The main idea is, when the output signal breaches the constraint, to slightly adjust the weight vector
if the reference signal has an obvious effect on the output signal, otherwise to adjust the weight vector substantially. Therefore, we add two base points, which are determined by the output signal and the power of the reference signal, and three gradient directions to better adjust the weight
vector. Furthermore, these improvements can reduce the weight fluctuation and precisely adjust the output signal within the constraint. In comparison with the conventional method, this strategy improves the noise reduction performance and stability, but the computational cost increases slightly.
The enhanced performance is verified by the simulation results with four different situations.
Quality Management of Laboratory and Diagnostic Studies
Authors: Русак А.А. , Алехнович Л.И. , Камышников В.С. , Шилейко И.Д.
Published: July 2022

В настоящее время большое внимание уделяется вопросам повышения качества медицинских услуг, в том числе лабораторно-диагностических: известно, что около 70% клинических и диагностических решений основывается на результатах лабораторных исследований. Для получения достоверных сведений, касающихся аналитического качества лабораторных данных, нужно выполнять установленные требования к его достижению. Лучшим способом определения качества лабораторного теста является применение «общей допустимой аналитической ошибки» (Allowable Total Error (TEa)). В настоящей статье представлены основные сведения о предложенных участниками первой стратегической конференции Европейской федерации лабораторной медицины (Милан, 2014 г.) трех независимых моделях требований к качеству лабораторных исследований, в числе которых: модель, основанная на оценке влияния аналитического качества на клинические исходы (1); модель, базирующаяся на учете особенностей биологической вариации аналита (2); и модель, основанная на достигнутом (текущем) уровне качества – «state-of-the-art» (достигнутый уровень аналитического качества) (3).На использовании процедуры определения общей допустимой ошибки (TEa), отражающей пределы отклонений аналита, базируется известная система менеджмента качества – система «Шесть сигм», которая к настоящему времени является одной из самых популярных концепций управления качеством лабораторных исследований.

Nowadays a lot of attention is focused on the improving the quality of medical services, including laboratory diagnostics segment: it is known that about 70% of clinical and diagnostic decisions are based on the results of laboratory tests. To obtain the reliable information regarding the analytical quality of laboratory data, it is required to fulfill the established requirements for its achievement. Using the "Allowable Total Error (TEa)" is the best way to determine the quality of a laboratory test.This article includes the main information about three independent models applied for the quality of laboratory research, proposed by the participants of the first strategic conference of the European Federation of Laboratory Medicine (Milan, 2014), including: a model based on assessing the impact of analytical quality on clinical outcomes (1); a model based on the characteristics of the biological variation of the analyte (2) and a model based on the achieved (current) level of quality – "state-of-the-art" (achieved level of analytical quality) (3).The well-known quality management system, the "Six Sigma" system, is based on the procedure for determining the total allowable error (TEa), which reflects the limits of deviations of the analyte, currently being one of the most popular concepts for laboratory research quality management.
Khabtagaeva, B. (Ed.). Historical Linguistics and Philology of Central Asia: Essays in Turkic and Mongolic Studies. Leiden-Boston: Brill, 2022, pp. 494, ISBN: 978-90-04-49995-9
Authors: DEMİRYAKAN Deniz
Published: July 2022

Khabtagaeva, B. (Ed.). Historical Linguistics and Philology of Central Asia: Essays in Turkic and Mongolic Studies. Leiden-Boston: Brill, 2022.
Eski Uygurca Sosyo-Ekonomik Belgeler Hakkındaki Çalışmaların Kaynakçası
Authors: UÇAR Erdem
Published: July 2022

Many research has been published on the documents called Old Uyghur Civil Documents. Wilhelm Radloff was the first scholar to edit these documents and it has been 125 years since his first book called Uigurische Sprachdenkmäler: Materialen. Therefore it has been necessary to prepare the bibliography of these studies. This bibliography is chronological and includes books, journal articles, conference presentations, chapters in edited volumes, etc. The bibliography also focuses on the naming and classification of Old Uyghur Socio-Economic Documents.
TOOLS AT THE CENTRE OF GOVERNMENT:RESEARCH AND PRACTITIONERS' INSIGHTS
Authors: Brown Dustin , Kohli Jitinder , Mignotte Samantha
Published: July 2022

In this paper, the authors look at how the 'centre of government' (defined as "the people and organisations that support the head of government as the ‘guardians of overall strategic direction of government’, which often includes the president’s or prime minister’s offices as well as Cabinet, budget offices, etc") can add value from their position and with the tools available to them. The COVID-19 pandemic has highlighted the critical role not just of government generally, but in particular the essential role the centre of government must play to coordinate, communicate with the public, and navigate new problems that no longer respect the organisational boundaries we have created over time. More generally, the problems that governments need to solve are increasingly complex and horizontal, yet government is organised by vertical institutions and hierarchies. Whether handed down as a special assignment by a political leader or self-driven as part of their role, staff in the centre of government are responsible for driving forward progress on the government’s top priorities. With easy access to senior government leaders, but relatively small budgets and staff, the centre of government has a very different set of tools than other agencies. The authors present ten tools across four clusters that centres of governments can deploy: Cluster 1 tools – Planning from the centre: defining success and setting up agencies to improve Cluster 2 tools – Governing from the centre: creating structures to drive improvements Cluster 3 tools – Improving implementation from the centre: creating routines and driving change Cluster 4 tools – Improving service delivery from the centre: supporting and offering provision of cross-cutting services The tools presented focus on specific actions that the centre of government can take to drive a priority area for a leader. They go beyond the traditional areas of responsibility that are more well known that inherently sit with the centre of government.
The Division Between Roma and Constantinople and the Norman Conquest of Italy
Authors: Кузенков П.В.
Published: July 2022

Раскол христианского мира на латинский Запад и греческий Восток, отправной точкой которого считаются анафемы 1054 г., протекал на фоне экспансии нормандцев в Южной Италии. Как показывает анализ источников, церковный конфликт имел глубинные корни и длительную предыстории, но решающим фактором в его развитии от дипломатического демарша к бескомпромиссному разрыву церковного общения стала, по нашему убеждению, именно антивизантийская борьба в Южной Италии, наложившаяся на стремление идеологов реформаторского движения в Римской Церкви вытеснить Византию из западноевропейского политического и культурного пространства как фундаментальную помеху на пути церковной интеграции Запада вокруг Престола Св. Петра. Византия, в свою очередь, отреагировала на эти процессы «демонизацией» западных народов и культивированием топоса латинской церковной традиции как искажённой «новшествами» и варварским бескультурьем «франков».

The separation of the Christian world into the Latin West and the Greek East, whose starting point is generally considered to be the schism of 1054, took place during the Norman expansion in Southern Italy. As the analysis of the sources shows, the ecclesiastic conflict had deep roots and a long pre-history, but the dominant factor in its development from a diplomatic demarche to an uncompromising schism was, in the author’s opinion, the anti-Byzantine struggle in Southern Italy, which coincided with the Roman Church’s desire to expel Byzantium from the political and cultural life of Western Europe, in order to consolidate the West around the See of St. Peter. Byzantium, on the other hand, reacted to these processes by «demonizing» the peoples of the West and cultivating the topos of the Latin ecclesiastic tradition as being distorted by «innovations»and the barbaric lack of culture of the «Franks».
Pengaruh Model Pembelajaran Reciprocal Teaching terhadap Kemampuan Penalaran Matematis dan Hasil Belajar Matematika Siswa Kelas VIII MTs AN-Nur Lenteng
Authors: Sufvinia Nur Suci Bahiyrah , Fitriyah Lilis Mariyatul , Indraswari Nur Fitriyah
Published: July 2022

Abstrak: Penelitian ini bertujuan untuk mengetahui apakah terdapat pengaruh model pembelajaran reciprocal teaching terhadap kemampuan penalaran matematis dan hasil belajar matematika siswa kelas VIII MTs An-Nur Lenteng Tahun Pelajaran 2019/2020. Penelitian ini menggunakan pendekatan eksperimen yaitu Pre Experimental dengan populasi kelas VIII di MTs An-Nur. Teknik pengambilan sampel dalam penelitian ini yaitu simple random sampling. Sampel penelitian yaitu kelas VIII-A sebanyak 15 siswa.Teknik pengumpulan datanya dengan menggunakan tes kemampuan penalaran matematis dan tes hasil belajar matematika. Sedangakan teknik analisis data yang digunakan adalah analisis statistik mengunakan uji N-gain dan uji-t.  Pengujian hipotesis dengan uji t didapat nilai thitung adalah 3,28045 sedangkan pada tabel nilai ttabel adalah 1,76131 pada taraf signifikan 0,05, dan derajat kebebasan 14, sehingga nilai thitung lebih dari ttabel  hal ini menunjukkan bahwa H0 ditolak dan Ha diterima.. Dengan demikian dapat disimpulkan bahwa ada pengaruh Model Pembelajaran Reciprocal Teaching Terhadap Kemampuan Penalaran Matematis dan Hasil Belajar Matematika Siswa Kelas VIII MTs An-Nur Lenteng Tahun Pelajaran 2019/2020.

Abstract: This study aims to determine whether there is an influence of the Effect of Reciprocal Teaching Learning Model on Mathematical Reasoning Ability and Student Learning Outcomes of Class VIII MTs An-Nur Lenteng in the 2019/2020 academic year. This study uses an experimental approach that is pre experimental with a class VIII population at MTs An-Nur. The sampling technique used was simple random sampling. The research sample is class VIII-A as many as 15 students. Data collection techniques using mathematical reasoning ability tests and mathematics learning achievement tests. While the data analysis technique used as statistical analysis using the N-gain test and t-test. Hypothesis testing with the t test obtained thitung is 3,28045 while in the table the value of ttabel is 1,76131 at a significant level of 0,05, and degrees of freedom 14, so the value of thitung more than ttabel this shows that H0 is rejected and Ha is accepted. Thus it can be concluded that there is an influence of The Effect of Reciprocal Teaching Learning Model on Mathematical Reasoning Ability and Student Learning Outcomes of Class VIII students of MTs An-Nur Lenteng in the  2019/2020 Academic Year
Pengembangan Buku Ajar Teori Bilangan Berbasis Direct Instruction
Authors: Julianingsih Denok , Widayanti Evi
Published: July 2022

Abstrak: Tujuan dari penelitian ini adalah menghasilkan buku ajar teori bilangan berbasis direct instruction yang berkualitas baik untuk mahasiswa keguruan pendidikan matematika STKIP Bina Insan Mandiri. Penelitian ini merupakan penelitian pengembangan dengan menggunakan desain pengembangan ADDIE dengan lima tahapan yaitu tahapan analisis (analysis), tahap perancangan (design), tahap pengembangan (development), tahap implementasi (implementation), dan tahap evaluasi (evaluation). Berdasarkan hasil uji coba buku ajar teori bilangan berbasis direct instruction, buku ajar dikatakan (1) valid berdasarkan penilaian validator dengan rerata penilaian sebesar 0,8916 atau sebesar 89,16% yang berada pada kategori sangat baik (2) praktis berdasarkan hasil dari pengamatan ahli bahwa buku ajar dapat digunakan di lapangan, pembelajaran juga berlangsung dengan sangat baik dan aktivitas mahasiswa selama pembelajaran juga sangat baik dengan prosentase keterlaksanaan pembelajaran sebesar 85% (3) efektif berdasarkan nilai rerata kelas sebesar 76,0125 dan pemberian respon positif mahasiswa dengan prosentase sebesar > 60% pada masing-masing indikator yaitu pada kategori cukup, baik, dan sangat baik. Sehingga dapat disimpulkan bahwa buku ajar teori bilangan berbasis direct instruction berkualitas baik.

Abstract: The purpose of this research is to produce a number theory textbook based on direct instruction for mathematics education teacher students at STKIP Bina Insan Mandiri. This research is a development research using the ADDIE development design with five stages, namely the analysis stage, the design stage, the development stage, the implementation stage, and the evaluation stage. Based on the test results of the number theory textbook based on direct instruction, the textbook is said to be (1) valid based on the validator's assessment with an average rating of 0.8916 or 89.16% which is in the very good category (2) practical based on the results of expert observations that textbooks can be used in the field, learning also takes place very well and student activities during learning are also very good with the percentage of learning implementation of 85%(3) effective based on the class average value of 76.0125 and giving positive student responses with a percentage of > 60% on each indicator namely in the category of moderate, good, and very good. So it can be concluded that the number theory textbooks based on direct instruction are of good quality
Studi Etnomatematika pada Rumah Tradisional Ammu Rukoko
Authors: Lakapu Meryani , Rowa Yohana Rina , Hia Jeri Jekson Jira , Bria Kornelis
Published: July 2022

Abstrak: Ammu Rukoko merupakan rumah adat yang dibangun berdasarkan unsur kebudayaan yang berkembang dalam masyarakat Sabu. Tujuan dalam penelitian ini adalah untuk mengetahui konsep- konsep matematika dan aktivitas matematika yang terdapat pada Ammu Rukoko. Penelitian ini merupakan penelitian kualitatif dengan desain etnografi. Instrumen utama dalam penelitian ini adalah peneliti, selain itu instrumen pendukungnya berupa pedoman observasi dan pedoman wawancara. Sumber data dalam penelitian ini yaitu 3 orang (tokoh adat, tukang bangunan dan tokoh adat). Data yang dikumpulkan dianalisis dengan mengacu pada alur analisis data Miles dan Hubermen yaitu mereduksi data, menyajikan data dan menarik kesimpulan berdasarkan hasil analisis data. Hasil penelitian ini menemukan dua hal, yaitu: (1) kegiatan matematis yang dilakukan oleh masyarakat pada proses pembuatan Ammu Rukoko, yakni: kegiatan mengukur dan menghitung. (2) konsep-konsep matematis pada Ammu Rukoko, yakni: konsep segitiga pada Ketangarohe, persegi panjang pada bagian pintu dan Papa Kelila, setengah lingkaran pada Baja Duru dan Baja Wui, kekongruenan pada Kijuaga dan translasi pada Gela Mone dan Gela Banni. Berdasarkan hasil penelitian, secara tidak sadar masyarakat Sabu sudah melakukan kegiatan matematis dan menerapkan konsep-konsep matematis dalam kebudayaan Ammu Rukoko

Abstract: Ammu Rukoko is a traditional house built based on cultural elements that developed in the Sabu community. The purpose of this study was to determine the mathematical concepts and mathematical activities contained in Ammu Rukoko. This research is a qualitative research with an ethnographic design. The main instrument in this study is the researcher, in addition to the supporting instruments in the form of observation guidelines and interview guidelines. The data sources in this study were 3 people (traditional leaders, builders and traditional leaders). The data collected was analyzed by referring to the data analysis flow of Miles and Hubermen, namely reducing data, presenting data and drawing conclusions based on the results of data analysis. The results of this study found two things, namely: (1) mathematical activities carried out by the community in the process of making Ammu Rukoko, namely: measuring and counting activities. (2) mathematical concepts in Ammu Rukoko, namely: the concept of a triangle in Ketangarohe, a rectangle on the door and Papa Kelila, a semi-circle in Baja Duru and Baja Wui, congruence in Kijuaga and translation in Gela Mone and Gela Banni. Based on the results of the research, the Sabu people unconsciously have carried out mathematical activities and applied mathematical concepts in the Ammu Rukoko culture.
THE INSIGHT OF IN SILICO AND IN VITRO EVALUATION OF OYSTER MUSHROOM (PLEUROTUS OSTREATUS) AGAINST COLORECTAL CANCER TARGETING TIMP-1
Authors: Permana Sofy , Wibowo Natalia Rara Kartika , Adani Safira Fairuz , Ayulanda Meiyin , Endharti Agustina Tri
Published: July 2022

Targeted therapy treatment in Colorectal Cancer (CRC) works specifically on a protein or target cell in cancer. It plays a role in the survival of cancer cells. Targeted therapy involves several monoclonal antibodies, one of which is cetuximab which targets the Epidermal Growth Factor Receptor (EGFR). However, there are cases of cetuximab resistance caused by activities of the Tissue Inhibitor of Metalloproteinase-1 (TIMP-1). TIMP-1 can activate the downstream EGFR signaling pathway, thereby that TIMP-1 activities need to be inhibited. Polysaccharide compounds in Pleurotus ostreatus have potential as an immunomodulator and anticancer. This study aimed to determine the potential interaction, types of bonds, the binding energy between the polysaccharide compounds Pleurotus ostreatus and TIMP-1, and survival assay of human adenocarcinoma colorectal (HT-29) cells. This research method compounds selection, data mining, compounds and proteins preparation, docking and visualization of docking results, and cell viability assay. To the study results, TIMP-1 interacted with α-glucan, β-glucan, and galactomannan, which were mediated by hydrophobic and hydrogen bonds. We found new two-point interaction of TIMP-1 with α-glucan and β-glucan on Glu156 and Lys157 that plays a role in the interaction with CD63. Therefore, TIMP-1 can be a candidate for a new ligand on colon cancer targeted therapy. Cetuximab and Pleurotus ostreatus Extract (POE) combinations inhibited the survival of HT-29 cells. The α-glucan and β-glucan may partially inhibit TIMP-1 so that the possibility of resistance due to the interaction of TIMP-1 with CD63 can be inhibited and polysaccharide from Pleurotus ostreatus has anticancer activity on HT-29 cells.