bluuebunny/crossref_metadata_2025 huggingface dataset:
The Effect of Marigold Leaves and Doxorubicin Toward Cell Cycle and Apoptosis of T47D Cells
Authors: Fauzia Anis , Wati Umi Any Tiyas , Rizkita Cahyaning Gita , Qori'ah Eka Wahyuni Nurul , Arifin Ibrahim
Published: January 2018

Doxorubicin is a commonly used chemotherapeutic agent in patients with breast cancer. The risk of side effect using of doxorubicin  such as cardiomyopathy and congestive heart failure which can lead to death. One of the  approach to overcome overloaded use of doxorubicin is the combined use with a chemopreventive agent (cochemotherapy), including the leaf extract of marigolds (Cosmos caudatus Kunth.). This research aims to reviewing the effect of the methanol extract of leaves of marigolds on the cytotoxic activity of doxorubicin in modulating cell cycle and apoptosis of breast cancer cells T47D. Determination of the cytotoxic activity of methanol extract of leaves of marigolds and doxorubicin as well as a combination of both conducted by MTT assay. modulation surveillance of cell cycle and apoptosis induction is done by using flowcytometry and analyzed by FACS Calibur program. Cytotoxicity assay single treatment of the methanol extract of leaves of marigolds produce use values of IC50 504,840 μg/ml, whereas IC50 values doxorubicin is 141,055 nM. The synergistic effect was shown a combination of methanol extract leaves marigolds and doxorubicin at concentrations of 84,17 μg/ml -23,5 nM; 84,17 μg/ml -47 nM; 126,25 μg/ml -23,5 nM; 252,5 μg/ml -35,25 nM and 252,5 μg/ml -71 nM with a combination index value (CI) consecutively of 0,5; 0,6; 0,6; 0,6 and 0,6. Observations modulation of cell cycle and apoptosis induction combination of methanol extract leaves marigolds and doxorubicin at concentrations of 84,17 μg/ml -23,5 nM, said that a combination of the methanol extract of leaves of marigolds and doxorubicin to inhibit the proliferation of cells in G2 / M phase and able to induce apoptosis of breast cancer cells T47D.Keywords: methanol extract of leaves of marigolds, doxorubicin, flowcytometry, cell cycle, apoptosis.
Oyster Mushroom (Pleurotus ostreatus) Inhibits Migration and Metastasis on 4T1 Breast Cancer Cells
Authors: Tika Lodyta Nawang , Wikanthi Layung Sekar Sih , Annur Shofa , Murwanti Retno
Published: January 2018

Metastasis is the main cause of death among brast cancer patient. Pleorotus ostreatus is known as anticancer agent that inhibits angiogenesis. Ethanolic extract of Pleorotus ostreatus (EEP) which contains lovastatin is predicted to inhibit metastatic cancer through inhibition of MMP-2 and MMP-9. The aim of this study was to determined antiproliferative and anti metastatic activity of EEPw (Ethanolic extract of wet Pleorotus ostreatus) and EEPd (Ethanolic extract of dried Pleorotus ostreatus ) in 4T1 metastatic breast cancer cells line. Qualitative analysis of lovastatin was determined by thin layer chromatography (TLC) using dicloromethan and etil acetat as mobile phase and lovastatin standard. Scratch wound healing assay was used to determine migration inhition ability of EEP while MMP-9 and MMP-2 activity were analysed by gelatine zymography. Molecular docking was performed to know the interaction between lovastatin and MMP-2 & MMP-9. The result showed that EEPw and EEPd contain lovastatin which were proved by spray reaction with anisaldehid. Each of EEPw and EPPd had cytotoxic activity with IC50 760 and 400 μg/mL respectively. Both of them inhibited closure for about 50 % on 4T1 metastatic breast cancer cells line compared to control. Either EEPw or EEPd decreased MMP-9 expression level compared to control. Lovastatin had higher affinity to bond with either MMP-2 or MMP-9 than native ligand. Overall, EEP could be developed as anticancer agent which was targeted on MMP-2 and MMP-9.Keywords : Pleurotus ostreatus, 4T1 metastatic cells, MMP-2, MMP-2, antimetastatic
Fermented Goat Milk Supplementation in Rats Hypercholesterolmic on Malonyldialdehyde and Description of Liver Histopathology
Authors: Mahdi Chanif , H. Untari , Padaga Padaga
Published: January 2018

Empirically, fermented milk product has been proven to improve and cure for several certain diseases. Bioactive peptides were produced through a fermentation process in goat milk promotes many benefits on body health. The present study revealed that goat milk was fermented using starter commercial 3% to produced yoghurt increased protein content significantly. By using SDS- PAGE, showed that the decomposition of protein fraction was better than the fresh goat milk. Results then were analyzed by LC-MS/MS and found out that there were three kinds of bioactive each peptide consisted of 16 amino acids and were protected from the action of the protease enzyme. Goat's milk yoghurt was treated per oral in mice after hypercholesterolemic diet for 14 days with dose range of 300 mg/kg; 600 mg/kg; and 900 mg/kg for 4 weeks (28 days). The results demonstrated three type of bioactive peptides performed activity as anti-hypercholesterolemia on mice models which showed highly significant (P <0.01) on the production of malondialdehyde (MDA) compared to control. Furthermore, goat milk yogurt also reduced MDA level and decreased fats accumulation in mice. Goat's milk yoghurt at dose of 600 mg/kg was able to provide the best therapeutic effect in lowering MDA level and with dose of 900 mg/kg also gave the best therapeutic effect in reducing the fat accumulation on liver. Based on histopathology observation, it was revealed that fermented goat milk reduced cells damage in liver. In summarize, these findings suggest that fermented goat milk promotes another activities as anti-hypercholesterolemia based on in vivo study.Keywords: Fremented goat milk, hypercholeterolmia, malonyldialdehyde, liver hispathology
Anticancer Effect of a Typhonium flagelliforme L. in Raji Cells Through Telomerase Expression
Authors: Purwaningsih Endang , Suciati Yulia , Widayanti Etty
Published: January 2018

Cancer cells have a relatively high telomerase activity compared to normal cells, so the cancer cells have the ability to continue to proliferate and undergo mitosis uncontrolled. Telomerase is an enzyme which responsible for telomere length, a DNA segment that is at the end of eukaryotic cell chromosomes. Telomeres and telomerase play a role in the incidence of carcinogenesis. Natural materials such as taro mice (Typhonium flagelliforme) have potential as anticancer. The purpose of the study was to determine the effects of plant extracts of rat taro on the expression of telomerase in cancer cell Raji. The research method is experimental studies in some form cancerous cell culture cell line, Raji. Used as a control normal cells is Vero cell. The Culture medium used RPMI for Raji cell  and M199 for Vero cell. The study consisted of three groups, control, doses of 1 ½ IC50 and IC50 doses. Expression of telomerase enzyme was measured by the Immunohystochemistry method (IHC). The results showed that the expression of telomerase in cancer cells showed values significantly higher than the normal cells (Vero). Giving mice taro plant extracts (Typhonium flagelliforme) were able to decrease the expression of telomerase significantly in both treatment doses. It was concluded that rodent tuber extract (Typhonium flagelliforme Lodd) can reduce the expression of telomerase in Raji cells, so that the rodent tuber extract (Typhonium flagelliforme Lodd) has potential as an anticancer through the expression of telomerase.Keywords: telomerase, IHC, Typhonium flagelliforme
Cinnamomum Essential Oil Prevents DNA Damage-Induced by Doxorubicin on CHO-K1 Cells
Authors: Wikanthi Layung Sekar Sih , Wulandari Nindi , Esti Yuni Fajar , Sari Nur Fitra , Susidarti Ratna Asmah
Published: January 2018

DNA damage usually happens due to the several chemical materials that induce genotoxic effect in normal cells. Cinnamon essential oil (CEO), which contains cinnamaldehyde as its major compound, has been reported to possess antioxidant activity to prevent DNA damage. The aim of this study is to evaluate the genotoxic and cytotoxic effect of CEO on doxorubicin-induced Chinese Hamster Ovary (CHO-K1) cells. The cytotoxic effect of CEO was determined by MTT assay with the parameter of IC50 while the genotoxic effect was carried out by micronucleus (MN) assay by using acridine orange fluorescent staining with the parameter of MN/1000 cells reduction number. Based on MTT assay, CEO showed cytotoxic activity with the IC50 value of 30 μg/ml and for MN assay, 3 μg/ml (1/10 IC50) of CEO decreased the percentage of micronucleus per 1000 cells up to 94,55%. Thus, the result can be summarized that CEO does not induce genotoxic and has the potency to prevent DNA damage caused by doxorubicin on CHO-K1 cells.Keywords: genotoxic, cinnamomum essential oil (CEO), micronuclei assay, in vitro
Ethyl Acetate Fraction of Caesalpinia sappan L. Enhances Cisplatin’s Cytotoxicity on HeLa Cells via G1 and S Arrest through p53 Expression
Authors: Husnaa Ulfatul , Laksmiani Ni Putu Linda , Susidarti Ratna Asmah , Meiyanto Edy
Published: January 2018

Cisplatin (cisp) is the first line chemotherapeutic agent for several cancer diseases which can cause significant side effects and cellular resistance. Combination-chemotherapy treatment (co-chemotherapy) was reported to be able to reduce cisp effects. Therefore, this study was carried out to investigate the cytotoxic activity of ethyl acetate fraction of C. sappan (EFC) in combination with cisp by observing apoptosis induction and cell cycle profile. Cytotoxic activity was evaluated by MTT assay. Cell cycle and apoptosis analysis were performed using flow cytometry and p53 expression was analyzed using immunocytochemistry. EFC performed cytotoxic effect on HeLa cells by showing morphological changes such as cell shrinkage, rounding and decreasing of cells viability in concentration dependent manner, giving IC50 value of 65 μg/mL. Combination of EFC and cisp in low concentration decreased cell viability into 36.86%. Further assay indicated that this combination caused redistribution of cell cycle arrest in G1 and S phases through p53 stabilization in nucleus. However, that mechanism was not followed by apoptosis. These results provide evidence to support EFC development as the enhancer of cisp effect, by improving its cytotoxicity on HeLa cells. EFC increases HeLa cells sensitivity to cisp through G1 and S cells’ arrest depending on p53 expression. Key words: co-chemotherapy, EFC, cervix cancer HeLa cells, p53, G1 and S arrest.
Doxorubicin Induces Lamellipodia Formation and Cell Migration
Authors: Amalina Nur , Nurhayati Ika Putri , Meiyanto Edy
Published: January 2018

Breast cancer is the main cause of cancer death among women, especially breast cancer metastasis. Metastasis process begins with the ability of cell cancer invasion. Doxorubicin, a antracycline chemotheraphy, is known to induce TGFβ1, thus promote invasion. The aim of this study is to optimize doxorubicin doses to induce lamellipodia formation in 4T1 and MCF-7/HER2 cells. Lamellipodia formation was observed by morphological changes using microscope inverted. The effect of doxorubicin on cell viability was analyzed using MTT assay. Rac1 expression after doxorubicin exposure was determined by western blotting. Lamellipodia formation was observed by morphological change of the cell at the dose 10, 25, 50 and 100 nM. Doxorubicin at the dose of 10 nM could induced lamellipodia formation without affect cell viability in both 4T1 and MCF-7/HER2 cells.  Doxorubicin induced cell cycle arrest at G2/M phase at all doses. Doxorubicin 10 nM also decrease Rac1 expression compared to control.Key words: Doxorubicin, lamellipodia, Rac1, migration.
Evaluation of The Genotoxicity of Three Food Additives using CHO-K1 Cells under in vitro Micronucleus Flow Cytometry Assay
Authors: Lestari Beni , Novitasari Dhania , Putri Herwandhani , Haryanti Sari , Sasmito Ediati , Meiyanto Edy
Published: January 2018

Exposure of genotoxic substances come from various sources such as food additives. The aim of this study is to evaluate the genotoxicity of food additives in CHO-K1 cells by micronucleus test flow cytometry. The food additives: sodium saccharine (SS), monosodium glutamate (MSG), and sodium benzoate (SB) were assessed by in vitro cytotoxicity and genotoxicity using Chinese Hamster Ovary-K1 (CHO-K1) cells. The cytotoxic effect of those compounds was evaluated by MTT Assay on CHO-K1 Cells. The genotoxic evaluation was observed by in vitro micronucleus test by flowcytometry with double staining method. The results showed that the three compounds did not perform cytotoxic effect, increased the frequency of micronucleus, and changed the cell cycle profiles. In general, these studies obtained that none of three food additives showed cytotoxic and genotoxic effect on CHO-K1 cells. Micronucleus test using flow cytometry is suitable for this purpose study.Key words : food additives, genotoxic, cytotoxic, micronucleus
Acetoxy Chavicol Acetate (ACA) Concentration and Cytotoxic Activity of Alpinia galanga Extract on HeLa, MCF7 and T47D Cancer Cell Lines
Authors: Suhendi Andi , Wikantyasning Erindyah Retno , Setyadi Gunawan , Wahyuni Arifah Sri , Da'i Muhammad
Published: January 2018

Due to severe side effect and non-specific chemotherapeutic agent, screening and discovery for cancer therapy are still working, especially from natural resources. Traditionally, people used herbal medicine either to prevent or cure diseases. One of herbal that commonly used in Indonesia is Alpinia galangal. Previous study stated that active compound is acetoxy chavicol acetate (ACA) and active as anticancer. This research aimed to determine ACA concentration and cytotoxic activity of Alpinia galanga extract (AGE) from three local markets on HeLa, MCF7 and T47D cell lines. The galangal used from three local markets namely Pasar Legi Surakarta, Beringharjo Yogyakarta, and Wonogiri. The extraction was performed by maceration using 96% ethanol as solvent. ACA quantitation using UV spectrophotometer at λ = 208.5 nm. Samples were prepared by liquid-liquid extraction using an ethyl acetate. Cytotoxic activities were performed by MTT assay. The result showed that the concentration of ACA of AGE from the three local markets were 3.798; 0.035; and 0.009 % w/w, respectively. Cytotoxic activity, describes as IC50 value, on HeLa cell line of AGE from three local markets, in order were 13.26; 36.32 and > 100 µg/ mL. Meanwhile, AGE from Pasar Legi on MCF7 and T47D cell lines have IC50 value of 15.80; 12.50 µg/ mL, respectively. In contrast, two other samples have IC50 values of greater than 100 µg/ mL. The highest activity was from the highest concentration of ACA on the samples.Key words: Alpinia galanga, HeLa, T47D, MCF7 and Acetoxy chavicol acetate
Tracking the Educationalization of the World: Prospects for an emancipated history of education
Authors: Tröhler Daniel
Published: January 2018

Abstract: Th is article reconstructs the rise, the national diff erentiations and the decline of the genre history of education and outlines subsequently what the history of education could mean if it emancipated itself from the conditions that lead to its emergence, religion and nationalism – conditions, that, nota bene, are by no means as dominant as they once were.Keywords: historiography of education, moralism, nation-building, history of the present
Change of Direction in Understanding the History of Education in Slovakia in the 1940s
Authors: Kudláčová Blanka
Published: January 2018

Abstract: The paper is a historical-educational study that aims to survey changes in the conceptual foundations of the field of the history of education in the 1940s, when a change of direction in its understanding, caused mainly by political circumstances, occurred. It was a complicated period with several overlapping ideological levels: the ideas of the interwar democratic Czechoslovakia “retired”, the national socialist ideology of the Slovak state was established in the situation of the war, and the Marxist-Leninist ideology, which was fully implemented after the communist coup in 1948, was being gradually shaped. A change of direction in the history of education and a change in its foundations will be demonstrated via two leading figures in the pedagogy of the period and their historical-educational work. Th e first one is Juraj Čečetka (1907–1983), the first Slovak professor of pedagogy. In 1940, he published his work Zo slovenskej pedagogiky [From Slovak Pedagogy], which can be considered the first Slovak scientific publication in the fi eld of the modern history of education. The second personality that signifi cantly infl uenced the character of pedagogy in Slovakia in the 1940s was Ondrej Pavlík (1916–1996). Th e conceptual foundations of his writings were different in comparison to Čečetka’s work and his successful establishment was aided by political engagement. His pedagogical work was predetermined by a dissertation thesis, Vývin sovietskeho školstva a pedagogiky (1945) [Development of Soviet Education and Pedagogy], and a monograph, Vysoké školy v Sovietskom zväze (1947) [Universities in the Soviet Union]. Discussing the work of Juraj Čečetka and Ondrej Pavlík, the following can be pointed out: 1. the close connection between personal conviction and political engagement and scientific work; 2. the impact of the ideology of totalitarian regimes on science and education, and 3. a change of direction in the understanding of the history of education under the influence of totalitarian ideologies and the difficulty of evaluating them objectively.Keywords: history of education, national socialist ideology, Marxist-Leninist ideology, Juraj Čečetka, Ondrej Pavlík.
The need for multiple types of information to inform climate change assessment
Authors: Toman Michael
Published: January 2018

Many critics of economic analysis of climate change impacts and response options claim that information is needed on ecosystem characteristics as well as on economic values to fully inform decisions about how climate change affects human well-being. Information on the irreversibility of impacts also is important, critics argue, because it relates to how society evaluates implications for intergenerational equity. In addition, because climate change is subject to a large degree of Knightian uncertainty, it is useful to understand both the information available for assessing climate change risks, and how individuals themselves perceive and evaluate risks. The paper discusses rationales for using these types of information as important complements to benefit-cost analysis for evaluating climate change risks and responses. Ideally such information could be available in a “dashboard” for decision makers assessing social and economic impacts, although limits on currently available information are a significant barrier to using that approach.
Lawful and unlawful surveillance in Mexican democracy / Vigilancia legal e ilegal en la democracia mexicana
Authors: Pérez Rivas Diego Alfredo , Mantovani Chiara
Published: January 2018

With the access to always more sophisticated and technologically advanced surveillance tools, it is crucial to develop progressive legislation to safeguard human rights and to ensure governments do not abuse their power by engaging in excessive state surveillance. This article investigates the use governments give to these surveillance instruments, focusing on Mexico. Firstly, we offer an overview of recent cases exposing governments' use of mass surveillance to repress critics. Secondly, we analyze what legislation is in place for data protection and privacy in some countries and how authoritarian governments employ surveillance methods to control their citizens. Thirdly, the Mexican legislation about data protection and access is presented. Fourthly, we describe how the Mexican authorities employ unlawful surveillance methods against critics with the complicity of telecommunications companies. Finally, we propose a few reforms to strengthen data and privacy protection in Mexico
Tres líneas de comunes y democracia / Three common lines and democracy
Authors: Boza Santiago Celia
Published: January 2018

Con la necesidad de poner fin a la comercialización de datos y dar lugar a la aparición de nuevas formas de gestión descentralizadas, aparece la línea de comunes que abogan por una ciudadanía más participativa. Este artículo se propone sistematizar y diferenciar tres líneas de comunes interrelacionadas, consideradas como motor del paso a una mayor transparencia para lo público, permitiendo la democracia directa. Finalmente, se proponen distintas alternativas de clasificación y gestión de los bienes comunes y redes de comunicación ciudadana  que facilitan su comprensión en el contexto actual.
De comentaristas del poder a ciudadanos colaborativos: el periodismo argentino en el siglo XXI / From elites commentators to collaborative citizens: Argentine journalism in XXI century
Authors: Amado Adriana
Published: January 2018

El periodismo tiene una relación con los campos sociales con los que interactúa, que determinan los factores de influencia en la identidad profesional. El periodismo de Argentina, lejos de su auto-imagen de periodismo comprometido, muestra una orientación hacia las elites políticas más que hacia los ciudadanos y una pérdida de iniciativa puesta en evidencia en la mayor presencia de información provista por terceros que la de factura propia. Para colmo, la debilidad estructural de la profesión dada por la falta de marcos éticos y legales le impide responder a las presiones de las fuentes de poder desde mecanismos profesionales. En este contexto, un camino hacia la diversidad de fuentes y pluralismo de temas puede ser la de incorporar a los ciudadanos no sólo como fuentes o como lectores, sino como colaboradores activos en la producción de información.
Using stored snow as cooling at Oslo Airport, Norway
Authors: Moe Jesper Mæx
Published: January 2018

A state-of-the-art snow cooling system was installed at Oslo airport in Norway in 2016 to reduce the energy costs of its new, bigger terminal building. Based on experiences of pioneering projects in Sweden and Japan, the environmentally friendly system is designed to reduce the summer cooling load by up to 5 MW. This paper describes the design and construction of the innovative snow cooling system and reports on its first 2 years of operation. In 2017 the system saved 375 MWh compared to conventional cooling systems and further improvements are expected over the next 2 years.
Integrating waste-to-energy in Copenhagen, Denmark
Authors: Hulgaard Tore , MSc Inger Søndergaard
Published: January 2018

Completed in 2017, the new Amager Bakke waste-to-energy project in Copenhagen, Denmark, is the largest of its kind in the Nordic countries. Its revolutionary design, including ski slopes on the roof and climbing walls, helps to integrate the facility with the city. As explained in this paper, the plant also has ultra-high energy efficiency and environmental performance, which required innovative solutions. Achievements include combined heat and power production with a net thermal efficiency of 107% and air emissions generally below 10% of limit values. Recovery of over 200 000 t of condensate a year could also replace other water resources, such as district heating water and make-up water.
Civil engineering heritage: country profile – Italy
Authors: Giannetti Ilaria
Published: January 2018

This paper is a review of Italy’s civil engineering heritage after the unification of the country (1861/1870), one of the series of national profiles being published by Engineering History and Heritage. This paper excludes ancient engineering works, as in Italy, these fall under the heading of archaeological heritage for both legal and cultural purposes, and focuses only on the civil and structural engineering heritage of the nineteenth and twentieth centuries. It is presented under four headings: ‘Italy’s major civil engineering achievements’, ‘National and regional recognition of engineering heritage’, ‘Exemplar conservation of engineering structures’ and ‘Information sources for engineering heritage’. The paper discusses engineering structures of heritage importance, including major iron and steel structures developed in the nineteenth century, such as the 150 m arch railway bridge over the River Adda in Paderno (1886); the urban arcades of Milan (1864), Genoa (1874) and Naples (1887); early application of reinforced concrete in large structures such as Risorgimento Bridge in Rome (1911); concrete dams for the development of the hydroelectricity industry, such as the Santa Chiara dam in Sardinia (1924); reinforced-concrete bridges and viaducts for the reconstruction of the national highway network after World War II, such as the viaducts of the Autostrada del Sole (1956–1964); and signature structures in reinforced concrete such as Pier Luigi Nervi’s domes for the Olympic Games in Rome (1960), Riccardo Morandi’s Polcevera viaduct in Genoa (1966) and Sergio Musmeci’s Basento Bridge in Potenza (1975). The paper concludes with a short list of organisations involved in the conservation of engineering structures and sources giving further information about Italian engineering heritage.
Seismic precursor to instability induced by internal erosion in loose granular slopes
Authors: Hu W. , Hicher P.-Y. , Scaringi G. , Xu Q. , Van Asch T. W. J. , Wang G.
Published: January 2018

Fluidised landslides are one of the most dangerous types of mass movements as they can run over long distances at high velocity. A flow-like landslide can occur in both artificially designed and natural slopes, resulting in extensive property damage and significant loss of life. Although various studies have examined the initiation mechanism of this type of landslide, the understanding of the phenomenon of instability which can occur in loose granular slopes deserves further attention. Specific influential factors, such as the changes in the soil microstructure due to water infiltration and seepage forces, still need to be further examined. In this study, the initiation of a fluidised landslide is investigated through flume tests. The tested material was collected from a coseismic landslide deposit in the 2008 Wenchuan earthquake area. These loose, granular deposits can fail due to intense rainfall and exhibit flow-like movement, potentially evolving into destructive debris flows. Two flume apparatuses have been used, which were equipped with multiple sensors to evaluate the pore pressures and the internal displacements. A high-sensitivity seismic accelerometer was installed at the bottom of the flume to record the vibrations produced by the movement of the soil particles during the tests. The soil mass was progressively wetted either by a uniform inflow from the ground surface at the top of the slope, to simulate the infiltration of run-off water arriving from upslope, or by a gradual rise of the water level at the upper boundary of the slope, to simulate a gradual rise of the groundwater table. Internal erosion of the finer soil fraction driven by the seepage forces is thought to have played a significant role in the slope collapse. Possible changes in the particle arrangement were recorded by the accelerometers in the form of an increasing high-frequency vibration signal before any significant rise of pore pressure and any significant displacement of the slope could be observed. Although further parametric investigation is still necessary, and tests at real scale should be devised, the observed behaviour suggests that seismic monitoring of loose, granular deposits could be a promising method for detecting an incipient slope collapse.
Effect of coarse aggregate content on shear friction of concrete
Authors: Lin Chien-Hung , Sun Wen-Chang , Xu Jiamin , Lin Bo-Yao , Lin Hua-Xi
Published: January 2018

Shear friction behaviour of normal- and high-strength concretes made with different amounts of coarse aggregate was investigated in this study. A total of 48 push-off specimens were made and tested. Twenty-four of the specimens were made with normal-strength concrete; the rest were made with high-strength concrete. The test variables included the concrete strength, coarse aggregate content and amount of shear reinforcement. The results show that an increase in coarse aggregate content would increase the splitting strength of concrete cylinder, ultimate shear friction strength and shear ductility of the push-off specimens for normal-strength concrete. However, there should be an upper bound of 950 kg/m3 to ensure better ultimate shear friction strength and ductility for high-strength concretes. The same amount of coarse aggregate could be the lower bound for normal-strength concretes to achieve the code-specified splitting strength. The ACI code shear friction strength calculations are conservative. The λ modification factor for normal-weight concrete as specified in the code may be raised up to 1·3, which was the lower bound found in this study.
Microstructure, thermal analysis and chloride penetration of self-compacting concrete under different conditions
Authors: Samimi Kianoosh , Dehghan Kamaragi Gholam Reza , Le Roy Robert
Published: January 2018

This paper concerns the characterisation of the raw materials used in four formulations of self-compacting concrete (SCC) and the study of their fresh state, compressive strength, thermal analysis, transport properties and chloride penetration under immersion and tidal conditions. The control concrete corresponds to a concrete with class 40 MPa based on Portland cement and limestone filler. A second formulation involves the complete substitution of limestone filler by sand filler. In the two other formulations, 10% and 15% of metakaolin are substituted for cement. The results show that SCC with metakaolin exhibits higher resistance to chloride penetration at different states. A higher strength development is obtained when using sand filler. This is true up to 90 d of maturation; beyond this, the compressive strength increases for the control SCC. However, mixtures with metakaolin present compressive strength values close to or higher than the ones of the control mix at both early- and long-term ages. This research shows that the substitution of Portland cement by 15% metakaolin in SCC is affordable in all aspects.
N-Phenacylthiazolium Salts as Inhibitors of Cholinesterases
Authors: Ocheretniuk Alla , Kobzar Oleksandr , Mischenko Iryna , Vovk Andriy
Published: January 2018

Inhibition of acetylcholinesterase is considered as a promising approach for treatment of neurodegenerative disorders including Alzheimer's disease. In this study, we demonstrated that 5-substituted N-phenacylthiazolium derivatives are capable of inhibiting acetylcholinesterase and butyrylcholinesterase activities with IC50 values in the micromolar range. Some of the new thiazolium-based inhibitiors showed more than 10-fold selectivity for butyrylcholinesterase. Kinetic experiments and molecular docking were performed for understanding the inhibition mechanisms.
Influence of Indifferent Electrolytes on Formation of Coagulative Structures in Aqueous Silica Dispersions
Authors: Goncharuk Olena , Andriyko Lyudmila , Marynin Andrii , Korotych Olena , Zarko Volodymyr , Ukrainets Anatolii , Gun’ko Vladimir , Malysheva Maria
Published: January 2018

Effects of indifferent electrolytes (NaCl, KCl, LiCl, NaI, NaNO3, CaCl2, and MgCl2) on the electrical double layer (EDL), aggregation, gelling, and rheological properties of aqueous dispersions of nanosilica were investigated. All examined indifferent electrolytes enhance interactions between nanoparticles of fumed silica through the coagulation mechanism. The critical concentration of gelation and gelling time decrease in the presence of the electrolytes, while the effective viscosity of the dispersions and average size of aggregates (Def) increase in series of chlorides: Li+ < Na+ < K+ < Ca2+ < Mg2+. That corresponds to an increase in the cation radius and reduction of the hydration shell. The nature of anions and cations significantly affects the values of Def and viscosity. For sodium salts, the viscosity increases in series I- < NO3- < Cl- corresponding to an increase in the hydration shell.
Associated plasma protein during the first trimester of pregnancy and pregnancy outcomes
Authors: Devi Vennapusa Rama
Published: January 2018

Background: Newborns are perhaps the most vulnerable population the world over. Preterm or babies born too early, less than 37 weeks gestation, are particularly at risk. Objective of present study were to determine the strength of relationship between PAPP-A concentrations using our own reference range and rates of idiopathic preterm delivery.Methods: A retrospective cohort study was conducted on consecutive singleton pregnancies undergoing first-trimester screening for fetal Down syndrome between 11 weeks and 14 weeks of pregnancy.Results: 500 patients in first trimester of pregnancy were selected in this study. 400 patients were found to have normal levels and were followed up till delivery. 20 patients developed preterm labour. Out of 100 patients who had low PAPP-A level, 35 patients had developed preterm labour. 15 patients out of 400 normal patients developed foetal growth retardation, 13 out of 100 low patients had foetal growth retardation. 5 out 400 normal patients developed PIH and no still birth was seen in normal patients. 15 out of 100 low patients had PIH and 2 patients had still birth. Most of the patients had asymmetrical FGR which concludes that there might be increased utero-placental resistance because of foetal growth restriction.Conclusions: In the first trimester of pregnancy, PPP-A level is an important predictor of outcome of obstetrics. A low level of PAPP-A is useful in indicating the risk of pre-term delivery and chance of PIH development.
Prenatal diagnosis of ornithine transcarbamylase deficiency: optimizing pregnancy outcome in a woman with previous affected babies
Authors: Galidevara Chandana , Chandrasekaran Swaramya
Published: January 2018

Ornithine Transcarbamylase (OTC) deficiency is an inherited X-linked disorder which predominantly affects males. Females are usually carriers and may rarely be symptomatic. Affected individuals may present with severe life threatening disease immediately after birth. Those with variants of the disease may have late adult onset symptoms. We report a case of an asymptomatic female heterozygous carrier of the defect with recurrent poor obstetric outcomes and subsequent management with prenatal diagnostic testing.
Использование краудфандинга, краудсорсинга и фандрайзинга для организации предпринимательских проектов
Authors: Калинина Ирина Анатольевна , Бармашов Константин Сергеевич
Published: January 2018

На основе стремительного развития информационных технологий современным предпринимателям стали доступны новые привлекательные возможности финансирования.
Эффективная организация предпринимательских проектов возможна за счёт использования технологий и инструментов краудфандинга, краудсорсинга и фандрайзинга.
В данной статье рассмотрены сущность и способы применения данных технологий для организации эффективных бизнес-моделей предпринимательства, а также проведен анализ творческого сообщества Kroogi, которое стало первой краудфандинговой платформой в России. Современные технологии технологий приобретает значимость в свете активного их использования в Российском шоубизнесе. Организация бизнес-моделей, используя технологии краудфандинга, фандрайзинга и краудсорсинга позволяет эффективно строить цепочки создания ценности.
Принципы инновационной экономики позволяют найти способы монетизации взаимодействия знаний и людей, обеспечивают повышенную проницаемость для всех национальных экономик.
Развитие научно-технологической инфраструктуры как фактор интенсификации инновационных процессов
Authors: Бабикова Анна Валерьевна , Ханина Анна Владимировна
Published: January 2018

В статье исследуются вопросы формирования и развития инновационной инфраструктуры в контексте разработки и производства инновационной продукции. Инновационные процессы на современном этапе сопряжены с определенными трудностями, связанными с несовершенством инновационной инфраструктуры, что затрудняет коммерциализацию инноваций. Выявлена роль университетов в создании и продвижении инноваций, определены основные аспекты взаимодействия научно-образовательных учреждений и промышленных предприятий в процессе перехода новых идей через объекты инфраструктуры в промышленный сектор региона. Научный и кадровый потенциал ведущих университетов позволяет считать их движущей силой инновационных процессов, активное использование объектов инфраструктуры существенно повысит потенциальные возможности трансфера технологий. Приведенные в статье результаты основаны на эмпирических данных Южного федерального университета, полученные результаты позволяют сделать выводы о перспективности развития инновационной инфраструктуры, основным элементом которой является университет.
Анализ драйверов и ограничений развития России на основе данных глобального индекса конкурентоспособности
Authors: Ченцова Елена Павловна , Ткачева Анна Сергеевна
Published: January 2018

По мере приближения к 10-летней годовщине большого финансового кризиса, мировая экономика демонстрирует обнадеживающие признаки восстановления. Однако, несмотря на позитивные тенденции, лидеры большинства стран сталкиваются с серьезными трудностями: неравномерное распределение выгод от экономического прогресса, рост неравенства в доходах в странах с развитой экономикой, ухудшение экологической ситуации и др. В сочетании с темпами роста, которые остаются ниже исторического уровня, перспективы развития мировой экономики становятся еще более неопределенными. В данной статье при помощи информации глобального индекса конкурентоспособности (ГИК) нами было проанализировано, на каком этапе развития находится Российская Федерация (РФ), определить текущее состояние и динамику 12 ключевых параметров ГИК, выявить драйверы экономики региона, позиционировать страну относительно стран объединения БРИКС, оценить его потенциал на мировом пространстве, назвать наиболее значимые ограничения, возникающие при ведении предпринимательской деятельности
Взаимодействие со стейкхолдерами как фактор повышения эффективности деятельности вузов
Authors: Тихонова Анна Дмитриевна
Published: January 2018

В статье рассматривается актуальность исследования того, что именно влияет на качественную оценку вузов стейкхолдерами и что способно повлиять на их стремление к взаимодействию. Автором проведен опрос, построенный как многоуровневая система, базирующаяся на сборе данных от студентов и выпускников образовательных учреждений высшего образования, абитуриентов, руководителей промышленных предприятий и прочих потенциальных работодателей выпускников вузов. На основании полученных данных, проведено аналитическое исследование по различным направлениям взаимосвязей между высшим образованием, обществом и рынком труда, которое позволило осуществить анализ отношения социума и промышленного сектора к взаимодействиям со сферой высшего образования. Автором проверена гипотеза о том, проблемой выпускников вузов является недостаток практических знаний и навыков и необходимых компетенций. Сделан вывод, что для дальнейшего улучшения эффективности, логика функционирования вуза должна со временем преобразовываться (эволюционировать), порождая новые модели, позволяющие образовательной организации выйти на успешную траекторию развития.
HÁBITOS MATERNOS RELACIONADOS À AMAMENTAÇÃO
Authors: Bezerra Jallyne Colares , Oliveira Rhaiany Kelly Lopes , Oliveira Brena Shellem Bessa , Sousa Suelen Alves , Melo Francisca Mayra Sousa , Joventino Emanuella Silva
Published: January 2018

Objetivo: caracterizar os hábitos relacionados ao aleitamento materno de crianças menores de cinco anos. Método: estudo descritivo, transversal, quantitativo. Foram entrevistadas 385 mães de crianças com idade inferior a cinco anos, em oito Unidades de Atenção Primária à Saúde do interior do Ceará, Brasil, no período de agosto a outubro de 2015.
Realizaram-se análises estatísticas descritivas. Resultados: constatou-se que 96,6% das mulheres amamentaram seus filhos, contudo, dessas, 40,7% amamentaram por um período inferior a seis meses. Das mães entrevistadas, 42,1% referiram não recorrer ao uso de chupeta para acalentar seus filhos, no entanto, 61,7% utilizaram mamadeira para a
alimentação da criança. Conclusão: constatou-se que um considerável número de mães desmamou precocemente seus filhos e, em consequência disso, elas introduziram novos alimentos antes do sexto mês de vida da criança.

Descritores: Aleitamento materno. Saúde da criança. Enfermagem.
ANÁLISE DE CONFORMIDADE E NÃO CONFORMIDADE DE UNIDADES DE SAÚDE DA FAMÍLIA
Authors: Souza Mariluce Karla Bomfim de , Barreto Leidiane Andrade , Silva Elaine Andrade Leal
Published: January 2018

Objetivo: identificar e discutir conformidades e não conformidades de unidades de saúde da família, de dois municípios do estado da Bahia, Brasil. Método: estudo descritivo e de avaliação normativa realizado em 23 unidades de saúde de um município de grande e outro de médio porte, no Nordeste brasileiro, no ano de 2014. Utilizou-se um roteiro de check-list elaborado a partir de manual ministerial sobre a estrutura física de unidades, sendo considerada a regulamentação técnica da Agência Nacional de Vigilância Sanitária e o programa EpiData para registro e arquivamento dos dados. Resultados: condições estruturais adaptadas e adequações de imóveis para o funcionamento de estabelecimentos de saúde podem interferir sobre a qualidade da oferta dos serviços. Conclusão: constatou-se a necessidade de estruturação e de priorização da Atenção Primária à Saúde, a fim de não comprometer a mudança do modelo assistencial.

Descritores: Avaliação em saúde. Estrutura dos serviços. Atenção primária à saúde.
PLANO DE PARTO COMO ESTRATÉGIA DE EMPODERAMENTO FEMININO
Authors: Mouta Ricardo José Oliveira , Silva Tania Maria De Almeida , De Melo Paula Titara Silva , Lopes Natália De Souza , Moreira Vanessa Dos Anjos
Published: January 2018

Objetivo: analisar como o plano de parto propiciou o empoderamento feminino durante o trabalho de parto e parto. Método: estudo exploratório qualitativo. Os dados foram coletados mediante a entrevista semiestruturada, entre maio e junho de 2016. O tratamento analítico empregado foi a análise de conteúdo. Resultados: a partir da análise dos dados emergiram três categorias: Plano de parto – um direito da mulher até então desconhecido; Plano de parto – uma tecnologia integrada à assistência do enfermeiro obstétrico; Plano de parto – uma tecnologia a favor do empoderamento feminino no parto. Com esse estudo, percebemos que existe um desconhecimento acerca do plano de parto,
independentemente da idade, escolaridade ou número de gestações das entrevistadas. Conclusão: destacou-se a importância do enfermeiro obstétrico atuando em partos e utilizando o plano de parto como uma tecnologia não invasiva. A construção do plano de parto durante o pré-natal contribui para o desenvolvimento favorável do trabalho de parto.

Descritores: Enfermagem obstétrica. Parto humanizado. Poder. Mulher.
ENFERMEIRA DE PRÁTICA AVANÇADA NA ATENÇÃO BÁSICA
Authors: Peduzzi Marina
Published: January 2018

EDITORIAL
The costs of utopia: Brasilia, Johannesburg, and Moscow
Authors: Bertaud Alain
Published: January 2018

A ideologia utópica poderia influenciar a estrutura espacial das cidades a ponto de sobrepor-se aos princípios básicos de auto-organização, que se propunham praticamente universais? Neste artigo, defino o conceito de ideologia utó- pica como uma doutrina imposta por um governo, seja local ou central, e que anseia em alcançar um estado futuro de equilíbrio permanente. Sob minha definição, a teoria do liberalismo econômico é o oposto da ideologia utópica, pois, primeiramente, mercados são criados espontaneamente por indivíduos ou firmas, não podendo ser impostos por governos; e segundo porque o liberalismo econômico implica em ajustes constantes em direção ao estado de equilíbrio impossível de ser previamente conhecido. Os pontos principais desenvolvidos neste artigo são (i) em alguns casos a ideologia pode tornarse a maior determinante da forma urbana, (ii) o resultado espacial de ideologias opostas são constantemente idênticos e (iii) Cidades moldadas por princípios utópicos impõem um custo que afeta negativamente o bem-estar de seus habitantes. Enquanto me concentro em três exemplos extremos de cidades moldadas pela utopia – Brasília, Joanesburgo e Moscou – também apresento que casos de ideologias mais suaves em cidades como Curitiba (Paraná, Brasil) e Portland (Oregon, EUA) têm apresentado um custo menor, mas não insignificante. Concluo que formas suaves de ideologia utópica ainda são comuns para regulamentar o uso da terra, que contribui com ineficiências e perda do bem estar social em muitas cidades modernas.
Transatlantic exchange: lessons from Brazil in the work of Norman Eaton (1902-1966)
Authors: Pienaar Marguerite
Published: January 2018

No período do imediato pós-guerra de fim dos anos de 1940, muitos arquitetos sul-africanos estavam profundamente influenciados pelo modernismo brasileiro. O arquiteto Norman Eaton (1902-1966), de Pretoria, foi um dos responsá- veis por disseminar a influência brasileira na África do Sul. Eaton foi influenciado especialmente pelo trabalho de Oscar Niemeyer (1907- 2012), a quem ele conheceu pessoalmente numa viagem pelas Américas em 1945. Na obra de Eaton, a tradução da variante moderna do modernismo brasileiro revelou-se compatível com atributos africanos. Foi provavelmente esse intercâmbio transatlântico que contribuiu para que Eaton encontrasse sua especificidade na transposição em direção a uma identidade africana.
A formação de núcleos urbanos no Brasil Colônia: procedimentos para elevar freguesias a vilas na Capitania de São Paulo na segunda metade do século XVIII
Authors: Salgado Ivone , Pereira Renata Baesso
Published: January 2018

As instituições municipais foram instrumentos essenciais na consolidação e defesa dos territórios coloniais. Durante o governo de Dom Luís Antônio de Souza Botelho Mourão (1765- 1775), o poder da Coroa na capitania de São Paulo se fortaleceu, a partir de ações militares, da produção de açúcar para exportação e da criação de uma rede de núcleos urbanos. Seus sucessores buscaram aprimorar estruturas que garantiriam os fluxos de pessoas e mercadorias no território e consolidar suas fronteiras. O trabalho é uma análise comparativa das práticas e discursos envolvidos na elevação de três freguesias a vila, em 1797, pelo Governador da capitania, Castro e Mendonça (1797-1802): Jaguary, Campinas e Araraytaguaba pertencentes às vilas de Atibaia, Jundiaí e Itu. O trabalho demonstra que as elevações respondem a diferentes estratégias de consolidação do território e fundamenta-se na documentação primária que representa os instrumentos de controle do território e do espaço urbano pela Coroa: cartografia, relações de população e ofícios das Câmaras e dos Governadores. O trabalho elucida o processo de constituição das vilas no território paulista no final do século XVIII, destacando o papel dos agentes do poder e demonstrando que o rito fundacional foi determinante na configuração espacial dos núcleos urbanos em questão.
Are students more interested in solving mathematics problems related to reality?
Authors: Anggaraa Anggi
Published: January 2018

Eleven lower-achieving girl students (13/14 years old) were asked about their task-specific interest in solving mathematics problems that either related or did not relate to reality, both before and after solving problems. Six of the eleven students were interviewed about the reasons behind their interest in particular problems. Furthermore, an interview was also carried out with a mathematics teacher, to know the types of problems that students usually worked on and studentsâ€™ interest in those problems from a teacherâ€™s point of view. The analysis revealed that students possessed different interests concerning problems, which either related or not with reality. However, generally, they preferred to solve problems that had no connection to reality, because they were easily able to work on such problems without much confusion. Keywords: Studentsâ€™ interest, modelling problems, dressed-up word problems, intra-mathematical problem.