bluuebunny/crossref_metadata_2025 huggingface dataset:
Coincidental Lesions that have been seen in Patients with Lumbar Discopathy at Spinal MR Examination
Authors: Ahmet Eroglu  , Ilhan Yilmaz
Published: February 2025

Introduction: The present Study has been made in order to investigate and examine the prevalence and type of the coincidental findings seen in patients with lumbar discopathy subjected to Lumbar Spinal Magnetic Resonance Imaging (MRI).
Tools and Method: 613 patients who were thought to have been Lumbar discopathy and who were subjected to Lumbar MRI have been examined. Lumbar MRIs were reported by musculoskeletal radiologists. Vertebra hemangiomas, tarlov cysts, Renal cysts, schmorl nodules, liver cysts were included in this study.  
Findings: Total 613 patients (male-female rate, 354: 259; age range, 16-79 years of age) were assessed. Vertebra Hemangiomas at 5.7% of the patients (n=35) vertebra hemangioma, at 3.5% of patients (n=22) tarlov cyst, at 2.2% (n=14) kidney cyst, at 1.4% (n=9) schmorl nodule, at 0.3% (n=2) of the patients liver cyst were found.
Conclusion: Detected coincidental findings have seen quite common at the examination of MRI of the patients with lumbar discopathy. Although the most of the coincidental findings which were detected at MRI of Lumbar Spine have been benign, the awareness of their prevalence is helpful in diagnosing the lesions which are not related with the symptoms.
Analysis of The Patients with Lichenoid Drug Reactions: A Retrospective Study.
Authors: Akbas Ayse , Kilinc Fadime
Published: February 2025

Objective: Lichenoid drug reactions (LDR) are a rarely known type of drug reaction that resembles lichen planus. The exact etiology of LDR is not known but it is thought to be caused by the triggering of all kinds of chemical substances. In this study; we aimed to investigate the clinical and demographic characteristics of the patients who were diagnosed with LDR.
Material and Method: The files of 56 LDR patients who were followed in our outpatient clinic among 2011 - 2016 have been reviewed retrospectively. The demographic characteristics, the drugs considered to cause reaction, the presence of multiple drug usage, the duration between drug intake and appearance of the initial skin eruption, clinical findings, lesion locations, laboratory findings and associated diseases have been recorded.
Results: Out of the 56 LDR patients, who were clinically and histopathologically diagnosed and followed, 36 were female and 20 were male. The average age was 52.8 (19-86 years of age). The duration of the symptoms was between 1-3 months in 58.9% of the patients, between 3-12 months in % 17.8, between 1 to 30 days in % 14.2 (n=8) and more than 1 year in 8.9% of the patients.48.2% (n = 27) of the lesions were on the extremities, 37.5 % were generalized, 7.1% were invers type. The most frequently accused drug groups were nonsteroidal anti-inflammatory drugs (NSAID) and antihypertensive.
Conclusions: It has been found that the use of NSAID, and cardiovascular drugs on their own and / or in combination with other medications often led to lichenoid drug reactions.
Gastrointestinal stromal tumor mimicking such as incarcerated inguinal hernia
Authors: Ferhatoglu Murat Ferhat , Kartal Abdulcabbar , Kivilcim Taner
Published: February 2025

Objective: Gastrointestinal stromal tumors, are most common sarcoma of the gastrointestinal tract, originate from Cajal cells which are responsible for the motility of the gastrointestinal tract. This sarcoma is most commonly observed in the stomach and small intestines can rarely be located in the omentum, mesentery or retroperitoneum. 
Case: Herein, we aimed to present a case of gastrointestinal stromal tumor presented as incarcerated inguinal hernia
Is ultrasound-guided transversus abdominis plane block in providing analgesia in pediatric cases safe and efficient?: A retrospective study
Authors: Binici Orhan , Kocaman Osman Hakan , Buyukfirat Evren , Karahan Mahmut Alp , Altay Nuray
Published: February 2025

Objective:  The use of high or insufficient doses of analgesics in pediatric cases unfavorably affects the patient’s health in the postoperative period. Ultrasound-guided transversus abdominis plane (TAP) block is used in the management of postoperative pain in pediatric cases. The present study aims to evaluate the efficacy of ultrasound-guided TAP block in pediatric patients using a mixture of lidocaine and bupivacaine.
Methods: The medical records of cases, who underwent surgery for the repair of the inguinal hernia and undescended testis using ultrasound-guided TAP block in the department of pediatric surgery, were retrospectively reviewed (28 cases). The study included ASA I-II pediatric cases aged 2-12 years. The amount of drug administered while performing USG-guided TAP block, time to first analgesic use in the postoperative period, pain score and the amount of first analgesic administration were recorded. The satisfaction of the surgeon and patient’s companion was evaluated.
Results: A p-value <0.05 was considered statistically significant. The findings showed that pain score was the lowest in the group with the highest patient’s companion and physician satisfaction score, and the highest in group with the lowest satisfaction score and the difference was statistically significant (p<0.001). The satisfaction of the physicians (p=0.010) and the patient’s companion (p=0.027) increased with increasing drug volume.
Conclusions: The volume of 0.4 ml.kg-1 (50:50 1% lidocaine and 2.5% bupivacaine) achieved the best physician and patient’s companion satisfaction and the longest duration of analgesia in pediatric cases undergoing surgery for the repair of the inguinal hernia and undescended testis. The lack of any complications in the present study suggests that USG-guided TAP block is a safe procedure in pediatric patients in experienced hands. Further studies are required.
Relationship of Total Antioxidant Capacity and Endothelin-1 levels in prehypertensive individuals among population attaining a sedentary lifestyle in central India
Authors: Saxena Tripti , Naz Sabiha
Published: February 2025

Objective: As known, hypertension has relation with increased peripheral vascular resistance. Vascular tone is regulated by multiple mediators; among them is Endothelin-1. Endothelin-1 (ET-1) is one of the most potent vasoconstrictors known to date. While its plasma /serum concentrations are elevated in some forms of hypertension. Prehypertension is one step towards hypertension, hence the same factor is involved in it. Oxidative stress is also found to be involved in pathogenesis of hypertension .Therefore our present study is designed to find the relationship between ET-1 levels and Total antioxidant capacity (TAC) in Prehypertension.
Methods: Total 100 prehypertensive cases and 100 sex matched controls were enrolled in this study. Inclusion criteria include patients with systolic blood pressure (SBP) in the range of 120 to 139 mmHg and diastolic blood pressure (DBP) in the range 80-90 mmHg, while patients with BP ≥140/90 mmHg, diabetes mellitus (DM), Stroke, coronary artery disease (CAD) and myocardial infarction (MI) were excluded. Plasma ET -1 and plasma total antioxidant capacity were measured .We estimated ET -1 levels and TAC levels in Prehypertensive cases and Normotensive controls. Students T test were used for statistical analyses.
Results: Plasma ET-1 levels were found significantly (p:0.001) higher in prehypertensive cases as compared to normotensive controls. In contrary to this, Plasma Total Antioxidant capacity was found extremely significantly lower in prehypertensive cases as compared to normotensive controls(p<0.0001).
Conclusion: The study demonstrated that in Prehypertensives, there is an inverse relationship between Endothelin-1 and Total antioxidant capacity.
An investigation of inappropriate medication use and dangerous drug combinations in elderly patients with polypharmacy
Authors: Baltacioglu Huseyin , Eroglu Oguz , Coskun Figen
Published: February 2025

Objective:  Polypharmacy is common among the elderly patients. The aim of this study was to determine drugs used inappropriately in elderly with polypharmacy or causing a dangerous drug combination (DDC) and to investigate the relation between drug interaction and emergency department (ED) presentation symptoms.
Methods: This prospective study was performed with elderly patients aged over 65. Patients’ demographic characteristics, presentation symptoms, comorbid diseases, and the names, numbers, dosages and side-effect of drugs used were recorded.
Results: DDC was present in 94.6% of patients, and 24.3% presented to the ED with drug interaction-related symptoms. The mean age of the patients with DDCs was 72.4±6.7 years, 68.3±5.5 years among those without DDC(p=0.016).The most common comorbid disease was hypertension(75.1%), the most commonly used drug group was anti arrhythmics (15.4%),and the most commonly used medication was aspirin(6.5%). The relation was observed between drug interaction-related presentation symptoms and coronary artery disease (CAD) (p=0.044). Correlation was determined between DDC and the anti-hypertensive drug group (p<0.001).Correlation was determined between drug interaction and subjects with presentation symptoms of dyspnea and bleeding (p<0.001 and p<0.001, respectively). Numbers of drugs used and frequency of presentation to hospital were higher in patients with DDCs (p<0.001; 0.040 respectively).Positive correlation was determined between frequency of presentation and number of drugs used(r: 0.514; p <0.001).
Conclusion: DDCs are more common as age increases in elderly. This situation especially remarkable in subjects with CAD and antihypertensive drugs users. Presentations to hospital caused by drug-drug interactions most commonly involve dyspnea and bleeding, and a higher number of drugs increase rates of DDC development and numbers of hospital presentations.
Investigation of antibiotic susceptibility profile and minimal inhibitor concentration changes in Pseudomonas aeruginosa isolates that exposed to subinhibitory concentrations of antibiotic
Authors: Kilinc Cetin , Guckan Ridvan , Coskun Umut Safiye Say
Published: February 2025

Objective:  During antibiotic use some of the bacteria in our flora can be affected by the used antibiotic in subinhibitory concentrations in addition to pathogenic microorganisms. The aim of this study to investigate in-vitro effects of subinhibitory concentrations antibiotic on antibiotic susceptibility profile of P.aeruginosa which can be found in normal flora and be a pathogenic bacteria.
Material and Method:  The antibiotic effective concentrations decrease with distance from the antibiotic disc and growth-inhibition zone ends with the effect of the antibiotic falls to subinhibitory concentrations; and growth starts.We accepted this growth starting region as the area in which bacteria exposed to subinhibitory concentrations of antibiotic are located and we developed a model. We separetely exposed the standard P.aeruginosa strain to eight different antibiotics (amikacin, gentamicin, imipenem, meropenem, ceftazidime, cefepime, ciprofloxacin, colistin) for seven days in subinhibitory concentrations. P. aeruginosa strain is susceptible to these antibiotics and we monitored susceptibility and minimal inhibitor concentration changes. Moreover, we also made these procedures in 20 different clinical P.aeruginosa isolates.
Results:  We observed that a resistance was developed in the standard P. aeruginosa strain starting second day of meropenem exposure, third day of ceftazidime exposure, fifth day of amikacin exposure and sixth day of gentamicin exposure. There was no resistance development after colistin, cefepime, ciprofloxacin, meropenem exposure but significant MIC value increases were detected. This resistance was not only against exposed antibiotic or antibiotic group but also against antibiotics in different antibiotic groups. 
Conclusion:  It was shown that especially subinhibitory concentrations using carbapenem and aminoglycoside antibiotics triggered resistance development against themselves more than other antibiotic groups. Use of colistin was not shown to cause cross resistance.
Strain Index Values in the Ultrasonographic Evaluation of Psoriasis
Authors: Menzilcioglu Mehmet Sait , Çitil Serdal , Akman Yasemin , Tüten Fatih
Published: February 2025

Objective: Psoriasis is a widespread, chronic, recurrent, inflammatory disease of the skin which affects men and women equally. Elastography is a novel technique which uses the elasticity of the lesion. The aim of this study is to determine the elastographic findings of dermal psoriasis. This is the first study to evaluate SI in psoriasis patients and SI is helpful to evaluate psoriasis patients. We suggest that determining cut-off SI values for normal and dermal psoriasis can be helpful in the early diagnosis and follow-up of psoriasis patients.
Materials and Methods: This prospective study included a total of 21 (10 females, 11 males) healthy volunteers and 32 (17 females, 15 males) psoriasis patients between 2015 and 2016. An Aplio 500 ultrasound device (Toshiba Medical Systems Corp., Otawara, Japan) and a 5-13 MHz linear transducer were used for ultrasonographic and ultrasound elastographic examinations. The measurements were made from the flexor sides of upper and lower extremities. At least three measurements were performed for each lesion and strain index (SI) values were recorded
Results: The median SI values of healthy volunteers and psoriasis were 1.25 (0.16-8.00) (interquartile range (IR) 1.50) and 2.73 (0.43-13.32) (IR 3.39), respectively, indicating a significant difference between the groups (p: 0.001).
Conclusion: Our study results showed that the SI values of the dermis in psoriasis patients were significantly higher than those of healthy volunteers. We suggest that determining cut-off SI values for normal and dermal psoriasis can be helpful in the early diagnosis and follow-up of psoriasis patients. Advances in Knowledge: Due to the literature search, this is the first study to evaluate SI in psoriasis patients and SI is helpful to evaluate psoriasis patients.
McArdle's disease in a Turkish woman due to an intronic variant of PYGM gene
Authors: Diniz Gülden , Çelik Canan , Dikbaş Oğuz , Duman Aslıhan , Nursal Ayşe Feyda
Published: February 2025

Objective: Glycogen storage disease type 5, also known as McArdle disease, is a hereditary disorder with progressive myopathy. It is characterized by onset of exercise intolerance with premature fatigue and painful muscle cramps in childhood or adolescence. Temporary myoglobinuria may occur after exercise due to rhabdomyolysis. Patients may have mild muscle weakness since childhood. Muscular atrophy with fatty replacement may develop in adult life. McArdle disease is a relatively benign disease and rarely severe myoglobinuria can cause acute renal failure as a complication of widespread rhabdomyolysis. This autosomal recessive disease is caused a homozygous mutation of the PYGM gene encoding muscle enzyme myophosphorylase C. 
Case: A 36-year-old woman admitted to the Physical Medicine and Rehabilitation polyclinic of Giresun University Hospital with a complaint of gradually increasing progressive weakness and tiredness since 13 years age. CK serum level has been found to in normal range; even after exercise. The findings demonstrated myogenic abnormalities on electromyography, multiple glycogen-containing vacuoles and undetectable muscle myophosphorylase activity on muscle biopsy. The genetic analysis revealed no pathogenic mutations in exon regions of PYGM gene. But in sequencing analysis, the rs71049658, insertion/ deletion variation in intron 17 was determined. Coenzyme Q10 (CoQ-10) 30mg/day, vitamin B6 250mg/day and L-carnitine 1gr/day treatment protocol has been applied and after two months the treatment, clinical improvement has been achieved. 
Conclusion: In this case report, an atypical McArdle case with a diagnostic challenge has been presented. We thought that this polymorphism in the myophosphorylase gene may lead to a severe mosaic alteration in mRNA splicing, including exon skipping, activation of cryptic splice-sites, and exon-intron reorganizations.
Acquired von Willebrand disease in chronic myeloproliferative disorders: a prospective single-center study
Authors: Ekinci Ömer , Aslanboğa Muhammed
Published: February 2025

Objective:  The rate of acquired von Willebrand disease (aVWD) among myeloproliferative patients is substantial enough to merit serious consideration, as it is thought to play a role in hemorrhage. We aimed to investigate the rate of acquired von Willebrand disease (aVWD) in chronic myeloproliferative disorders (MPD)
Materials and Methods: The present study was conducted prospectively on 70 patients admitted to hematology clinic. Complete blood count, PT, aPTT, vWF:Ag level, vWF:RCoF test, and factor VIII levels were analyzed for all patients. A finding of vWF:RCoF / Ag < 0.7 was accepted as the predisposition to aVWD.
Results: Of the patients, 33 (47.1%) were male, 37 (52.8%) were female, and the mean age was 50 ± 16.25. We detected aVWD in 19 (vWF:RCoF / Ag test < 0.7) (28%) of the 70 patients in the study group. Predisposition to aVWF was present in 7 of the 16 patients in the ET group(43.7%), in 4 of the 11 PV patients (36%), and in 8 of the 43 CML patients (18.6%). There was no statistically significant difference in the presence of aVWD between the three disease groups (p: 0.079).
Conclusion: The underlying mechanism of aVWD is still not fully resolved. Myeloproliferative diseases are one of the few diseases that can cause avWS. It should be kept in mind that aVWD may play a role in pathogenesis in people with chronic myeloproliferative disease, especially in cases of hemorrhage occurring in ET and PV patients.
Investigating demographic, socioeconomic, and obsteric risk factors of term intrauterine stillbirth cases
Authors: Kafadar Özgül Oğuz , Tekin Özlem Moraloğlu , Çoşkun Buğra , Özgür İrem Güler , Çoşkun Bora
Published: February 2025

Objective: To establish the prevalence, etiology, demographic, socioeconomic, and obstetric risks factors of intrauterine fetal deaths among term pregnancies with no risk factors. Our study is the first to investigate term stillbirth risk factors in such a large population.
Material and Methods: A total of 96 cases of stillbirth between 37th and 42nd weeks with no risk factors out of 90,557 births conducted in 2011-2015 were investigated retrospectively. Eighty patients that had stillbirth in our clinic were chosen as the study cases and 80 others that had risk-free live birth at the weeks of 37-42 chosen randomly accepted as the control group. Variables such as age of mothers, gravidas, parities, level of education of mothers, time since the previous pregnancy, BMIs, weight gained during pregnancy, gestational week, birth weights of infants, systolic and diastolic blood pressures, hemoglobin values, blood glucose levels, white blood cell counts, smoking history, follow-ups at the hospital, gender of babies, and seasonal distribution of stillbirths were evaluated.
Results: The stillbirth rate was found as 14 per million and stillbirth in risk-free population at 37-42 weeks was 1.05 per mill. BMI, hemoglobin levels, and systolic blood pressures of mothers were significantly higher in stillbirths. Any statistically significant difference in mean maternal age, gravida/parity, education level, weight gained during pregnancy, smoking and fetal gender distribution was not established between the groups
Conclusion: Term stillbirths in the risk-free group may be correlated with advanced gestational week, increased BMI, systolic blood pressure, and hemoglobin levels of the mother also insufficient antenatal follow-up.
Tratamento do Carcinoma de Células Renais: Abordagens Atuais
Authors: BARROS DE MACEDO RYAN RAFAEL , WALBER MACHADO ISADORA , AZEVEDO DE SALES EVELIN BEATRIZ , PEREIRA DOS SANTOS JOCENIR , SALES DE BARROS LUANA , PURPER ARRUDA JOÃO GABRIEL , TORRES MARCONDES MARCOS , YUJRA QUELALI SONIA LORENA , GRANJEIRO SOARES LORENA LILIAN , BAJUK GABRIELLA , MOURA DE AZEVEDO GABRIELA MARIEL , DE ALMEIDA SALES COSTA FABIO
Published: February 2025

RESUMO
O carcinoma de células renais (CCR) é a neoplasia maligna renal mais comum em adultos, sendo responsável por significativa morbimortalidade. O avanço no conhecimento da fisiopatologia do CCR impulsionou o desenvolvimento de novas abordagens terapêuticas, incluindo terapias-alvo e imunoterapias, além das estratégias cirúrgicas tradicionais. Esta revisão bibliográfica teve como objetivo sintetizar as informações mais recentes sobre o tratamento do CCR, por meio de uma busca sistemática na base de dados PubMed, considerando publicações dos últimos cinco anos. Foram incluídos artigos que abordam os principais tratamentos disponíveis, enquanto estudos irrelevantes para o tema foram excluídos. A análise dos dados evidencia que a escolha terapêutica depende de fatores como o estágio da doença e as características individuais do paciente, destacando a importância de estratégias personalizadas. O aprimoramento contínuo das abordagens terapêuticas e a integração de novas opções de tratamento são fundamentais para melhorar os desfechos clínicos.
Desafios e Avanços no Tratamento da Insuficiência Cardíaca Aguda
Authors: BARROS DE MACEDO RYAN RAFAEL , VILA NOVA DOS SANTOS LETICIA FERNANDA , STONE DE ANDRADE ANA LAURA , TEMBE DE SOUZA THIAGO , AZEVEDO DE SALES EVELIN BEATRIZ , PEREIRA DOS SANTOS JOCENIR , SALES DE BARROS LUANA , PAVIN SICHIERI GESSOLO JAILSON , PIRES TEIXEIRA VIULA CAROLINA , VIEIRA GENTIL ANDERSON , BARBOSA CASTILHO LOLA ESTELA , DE ALMEIDA BATISTA ALECIO
Published: February 2025

RESUMO
A insuficiência cardíaca aguda (ICA) representa um dos principais desafios na prática clínica, dada a sua alta morbidade e mortalidade. Este artigo revisa as abordagens terapêuticas atuais no tratamento da ICA, com ênfase nas terapias descongestionantes, como o uso de diuréticos intravenosos, e a análise dos benefícios e limitações de terapias adicionais, como vasodilatadores e inotrópicos. Além disso, são discutidos os modelos de cuidado multidisciplinar (HF-MPs), que têm se mostrado eficazes na redução da mortalidade e das hospitalizações. No entanto, os dados sobre terapias farmacológicas específicas para a ICA são inconclusivos, e há a necessidade de mais estudos para otimizar as intervenções e compreender melhor os impactos a longo prazo. A abordagem integrada, que inclui o manejo de comorbidades e o monitoramento contínuo dos pacientes, é fundamental para melhorar os resultados clínicos e reduzir o risco de readmissão hospitalar.
Manejo Neurocirúrgico de Traumatismos Cranioencefálicos Graves em Crianças na Emergência
Authors: Ceschini Nádia , Floriano Caroline Hernandes Ferreira , Godinho Breno Veggi , Bersaghi Gustavo Paraboni , Mello Bruna Regina Marinho de , Queiroz Vinicius Kaiser , Comparim Eduardo José , Filho Jackson ferreira de Souza Santos , Gonçalves Túlio César , Bellaver Leticia Massoco Rios , Raposo Carla Weruska De Lourdes Cangello , Tavares Rafael barrueco , Vieira Almir Fernandes Simões , Freitas João Henrique Affiune de , Prado Giovanna de Castro do Amaral Monteiro
Published: February 2025

Resumo
Introdução: Os traumatismos cranioencefálicos (TCEs) são uma das principais causas de morbidade e mortalidade em crianças. O manejo correto é fundamental para melhorar os desfechos neurológicos. Classificação da Gravidade: Utilização da Escala de Coma de Glasgow (ECGl) para determinar a gravidade da lesão.  - ECGl entre 13-15: leve- ECGl entre 9-12: moderado ECGl entre 3-8: grave. Por isso vamos poder analisar os dados em especial em TCEs graves. Medidas incluem elevação da cabeceira, controle da sedação, e uso de diuréticos osmóticos como o manitol.
Este estudo visa analisar a epidemiologia do traumatismo cranioencefálico na população jovem brasileira entre os anos de 2012 e 2022. Métodos: Foi realizado um estudo descritivo-analítico utilizando dados do DATASUS sobre traumas intracranianos em pessoas de 0 a 11 anos no Brasil nesse período. Resultados: Foram registradas 247.116 internações, que resultaram em 8.936 mortes, totalizando uma taxa de mortalidade de 3,61%, com um custo médio de R$266,30 por dia e um tempo de internação de 4,2 dias. O perfil epidemiológico dos pacientes com trauma intracraniano são predominantemente homens pardos na faixa etária de 15 a 19 anos, principalmente oriundos da região sudeste. Discussão: A morbidade e mortalidade em jovens é mais acentuada entre os 15 e 19 anos, com elevados custos hospitalares devido a intervenções clínico-cirúrgicas para tratar infecções ou realizar drenagens de hematomas intracerebrais. O custo relacionado ao tratamento pós-hospitalar é pouco discutido, sendo ligado ao cuidado com sequelas, à prevenção de novas lesões e ao acompanhamento multidisciplinar especializado. Conclusões: O trauma intracraniano em jovens representa uma questão relevante em nossa sociedade, implicando em prejuízos sociais e funcionais, além de um número considerável de óbitos. Portanto, é crucial desenvolver ações preventivas voltadas para a redução desses eventos traumáticos.
Restaurações biomiméticas minimamente invasivas em dentes anteriores: relato de caso
Authors: Oliveira Guilherme Miguel Moreira de , Da Mota Heloísa Caroline , Gandra Neto Renato Ferreira , Furuse Mariana Alves , Sousa Isadora Castaldi , Garroti Pedro Henrique Faneco , Oliveira Auanny Souza , Perazza Bruna , Esteves Lara Maria Bueno , Frascino Sandra Meira Borghi , Pavani Caio César , Catelan Anderson
Published: February 2025

Sorrisos que seguem proporções anatômicas equilibradas são naturalmente mais atrativos e isso está relacionado à autoestima e na forma como uma pessoa é percebida socialmente. Assim, a crescente busca por um sorriso estético e as repentinas mudanças de padrões estéticos sociais impulsionam avanços em técnicas restauradoras. Nesse contexto, a odontologia biomimética ganha destaque ao oferecer soluções estéticas que preservam ao máximo a estrutura dental natural, por meio de técnicas minimamente invasivas, visando atender às expectativas estéticas dos pacientes de forma conservadora e funcional. O objetivo deste estudo é relatar um caso clínico com uma abordagem biomimética e minimamente invasiva para a restauração de dentes anteriores. Relato de caso: paciente do sexo feminino, 28 anos, compareceu para atendimento com a queixa de insatisfação devido a trinca de borda incisal do dente 11; além disso, foi observada uma restauração classe III com cor insatisfatória na face distal do 21. A utilização da técnica incremental demonstrou-se eficaz para mimetizar a estrutura natural dos dentes e mascarar a linha de interface adesiva. As técnicas minimamente invasivas e biomiméticas são eficientes no restabelecimento estético e funcional de dentes anteriores.
ACOLHIMENTO COM CLASSIFICAÇÃO DE RISCO EM UM CENTRO OBSTÉTRICO
Authors: Nascimento Maria Eduarda Bezerra do , Araújo de Freitas Cavalcante Maryane Francisca , Júlio de Rosa Victor Hugo , Silva de Arruda Ana Paula , Vieira Vockes Victoria , Annichini de Oliveira Bianca , Leonardo Cosmo da Silva Vinicius , Dos Santos Ferreira Mirian , Alves de Souza Ana Christina , Santos Gomes de Sena Ester dos , Silva de Oliveira Mariana , Ferreira Gomes Thamara
Published: February 2025

O acolhimento com classificação de risco em centros obstétricos é uma estratégia fundamental para garantir um atendimento seguro, ágil e humanizado às gestantes, parturientes e puérperas. Esse modelo de triagem possibilita a identificação precoce de condições que exigem intervenção imediata, reduzindo complicações materno-fetais e otimizando a alocação dos recursos assistenciais. O objetivo deste estudo é analisar a importância dessa abordagem na qualidade da assistência obstétrica, destacando seus benefícios, desafios e impacto na segurança materno-infantil. Os resultados da revisão da literatura evidenciam que a implementação de protocolos padronizados de classificação de risco melhora a eficiência do atendimento e reduz o tempo de espera para casos graves. Estudos apontam que a atuação do enfermeiro nesse processo é essencial para garantir uma triagem adequada, permitindo que gestantes em situação de urgência sejam rapidamente encaminhadas para o atendimento especializado. No entanto, desafios como a falta de capacitação profissional, a escassez de recursos e a sobrecarga dos serviços de saúde comprometem a efetividade dessa estratégia. Além disso, a ausência de padronização dos critérios de risco pode levar a erros na priorização dos atendimentos, impactando negativamente os desfechos maternos e neonatais. Conclui-se que o acolhimento com classificação de risco tem um impacto significativo na qualidade da assistência obstétrica, promovendo maior segurança e humanização no atendimento às gestantes. Para que sua implementação seja eficaz, é necessário o fortalecimento da capacitação profissional, a estruturação dos serviços de saúde e o desenvolvimento de políticas públicas que garantam a padronização dos protocolos de triagem. Dessa forma, essa estratégia pode contribuir significativamente para a redução da morbimortalidade materna e neonatal, assegurando um cuidado mais eficiente e acessível às mulheres.
ANALISIS PERAN BAHASA INDONESIA SEBAGAI MEDIA KOMUNIKASI DALAM INTRUKSI PELATIH OLAHRAGA
Authors: Ratu Fauzar Kusmawarti  , Pauzi Muhamad Pikri , Purnama Suparman Nizwar Adriansyah , Sulastri Gulo Silvia Endang , Riska Dwi Purwanti  , Mochamad Whilky Rizkyanfi
Published: February 2025

Penelitian ini bertujuan untuk memahami peran Bahasa Indonesia dalam interaksi antara pelatih dan atlet selama proses pelatihan olahraga. Bahasa Indonesia tidak hanya berfungsi sebagai alat komunikasi, tetapi juga sebagai sarana untuk memperkuat hubungan sosial dan membangun identitas tim. Melalui penggunaan bahasa yang familiar, pelatih dapat menyampaikan instruksi teknis dengan lebih jelas, mengurangi kesalahan pemahaman, dan menanamkan nilai-nilai penting seperti disiplin, kerjasama, dan kebanggaan nasional. Penelitian ini menunjukkan bahwa penggunaan Bahasa Indonesia dalam pelatihan berkontribusi pada suasana kolaboratif yang mendorong motivasi dan kinerja atlet, serta memperkuat ikatan emosional antara pelatih dan atlet. Dengan demikian, bahasa berperan penting dalam pengembangan identitas nasional dan budaya di kalangan atlet.
Kata Kunci: Bahasa Indonesia, pelatihan olahraga, hubungan pelatih-atlet, identitas nasional, motivasi atlet.
Modern means of developing and strengthening work motivation of staff of higher education institutions
Authors:   Khmelnytskyi National University, Kravchyk Yurii
Published: February 2025

In the article, the subject of the study is the formation and use of modern means of development of higher education institutions and strengthening the work motivation of their personnel. It has been proven that the motivation of work in economic entities that provide educational services, one of the features of which is direct contact with the consumer of the service, plays a decisive role in the sense of economic efficiency, strengthening the competitiveness of services and the educational institution in general, development, as well as the implementation of critically important social functions of educational institutions. Therefore, the purpose of the research is to substantiate the set of modern means of development and strengthening the work motivation of the staff of higher education institutions, considering the specifics of domestic realities. Regarding recommendations for developing domestic institutions of higher education, it is proposed to use a more specialized and professional approach, including the broadest possible use of institutional-collective partnership practices. Material and non-material tools are proposed to increase the work motivation of the staff of higher education institutions. The scientific novelty of the study consists in the improvement of the methodical approach to the comprehensive evaluation of the potential of the work motivation of the personnel of higher education institutions, as well as the development of cooperation practices of employers and higher education institutions as determinants of ensuring balance in the labor market, which made it possible to identify barriers and catalysts for the development of dual education, to substantiate the triggers for increasing the potential for establishing contractual partnership relations between business entities and educational institutions. The practical significance of the research results lies in the fact that the article proposes and substantiates an applied approach to assessing the potential of dual education, the implementation of which will contribute to the formation of regional monitoring of the progress of higher education and strategizing, the development of innovative concepts for ensuring that the quality of professional education meets the requirements of the labor market.

Keywords: management, personnel, work motivation, institutions of higher education, development, modern management tool
Diagnostics of latest trends in the formation of patterns of consumer economic behavior
Authors:   Cherkasy State Technological University, Prodanova Larysa , Fomina Olena ,   SHEE Donetsk National Technical University
Published: February 2025

The article is dedicated to identifying the latest trends and factors shaping patterns of consumer economic behavior. The main characteristics of consumer behavior patterns are repeatability, predictability, complexity, adaptability, individuality, and rationality. The article aims to identify the latest trends and factors that shape patterns of consumer economic behavior in the context of orientation to innovations and digitalization processes. The methodological basis of the research is a comprehensive approach to diagnosing the latest trends in the behavior of economic subjects, which involves identifying and grouping factors (global, pan-European, national scale) of transformation of consumer economic behavior patterns under the influence of digitalization processes in society and economy – on a universal scale; specific factors of military influence – at the level of Ukraine’s national economy and on the scale of its territories. It is noted that consumer behavior models developed based on modern applied research differ in the following key aspects: the number of identified stages and degree of detail; research focus; consideration of “external” environmental factors and “internal” factors of consumer behavior; consideration of feedback; industry specifics; consideration of cultural peculiarities of consumption in different countries or regions; focus on short-term decisions or long-term perspective. It is proven that digitalization significantly transforms consumer behavior, affecting their habits, expectations, and decision-making processes. The main aspects of this influence include the growth of online purchases, use of mobile devices, personalization of experience, influence of social networks, increased awareness and demands, and changes in consumption structure. When examining the national characteristics of Ukrainian consumer behavior, it is necessary to consider the negative factors of military influence. The transformation of consumer behavior models during wartime occurs due to high sensitivity to price dynamics, changes in consumer priorities, increased empathy and activation of support for local producers, and rapid adaptation to changes.

Keywords: economic behavior, consumer behavior model, trend diagnostics, factors forming the model, digitalization, innovation, military influence.
Processing of modern time series of earth’s polar motion
Authors:   West Ukrainian National University, Lukianchenko Iurii , Lopushanskyi Oleksandr , Gumennyi Mykhailo , Muzyka Nataliia , Tartachynska Zoriana ,   West Ukrainian National University
Published: February 2025

Technologies of today are advancing at a rapid pace, requiring increasingly precise means of coordinate measurements. Thus, monitoring the positions of dams, nuclear power plants, skyscrapers, and other precision-engineered structures demands millimeter-level accuracy in coordinate determination, or, in some cases, even greater precision. One of the primary technologies that enables such high-precision measurements is GNSS (Global Navigation Satellite Systems). Typically, satellite ephemerides are determined in a celestial reference frame, while the coordinates of points obtained from GNSS measurements are defined in a terrestrial reference frame, fixed to the Earth’s body. Hence, it is essential to account for the relationship between celestial and terrestrial reference frames. An important component of this relationship, alongside precession and nutation, is the phenomenon of Earth’s polar motion. This phenomenon describes the variation in the position of Earth’s rotation axis within the planet’s body, whereas precession and nutation characterize the motion of the rotation axis in space.The article analyzes time series of polar motion. The trend of the x and y coordinates of polar motion has been calculated. The average direction of the Earth’s rotation axis movement within its body has been determined. Additionally, the average period of the axis rotation and the spherical radius of such rotation over the past decades have been established. Corresponding graphs have been constructed, and the obtained results have been illustrated.

The purpose of the article is to calculate the parameters of polar motion over the past three decades and present the results in the form of clear visual illustrations. This information can be used by researchers in related fields as input data for their studies.

Keywords: Earth’s polar motion, GNSS, time series analysis.
Rola stresu oksydacyjnego w starzeniu komórkowym
Authors: Dabrowska Magdalena
Published: February 2025

Cellular senescence is the permanent inhibition of cell division caused by stressors that lead to the induction of a DNA damage response. Depending on the type of stress, three main types of cellular senescence are distinguished: (i) replicative senescence triggered by telomere shortening (ii) accelerated senescence induced by factors other than telomere shortening, (iii) senescence caused by oncogene activity. Cellular senescence occurs in normal and cancer cells. Senescence of normal cells is the main mechanism underlying aging and the diseases of old age. Cancer cell senescence is often a response to therapy, and primarily it constitutes a form of tumor dormancy. Increased production of reactive oxygen species accompanies all types of cellular senescence. Oxidative stress is considered to play an essential role in both the induction and maintenance of the senescent state. Oxygen free radicals exert a dual function in cellular senescence: a signal transmitter and an agent that damages macromolecules. This article describes the sources and role of oxygen free radicals in various types of cellular senescence.
Zegar epigenetyczny i jego cofanie - nadzieja na wydłużenie zdrowego życia
Authors: Bielak-Żmijewska Anna
Published: February 2025

The aging process of the organism is inevitable. However, we age at different rates, and a lot is already known about how to delay this process and reduce the risk of age-related diseases. Lifestyle, proper diet, physical activity, preventive health care, and coping with stress play an important role in aging. Cellular senescence lies at the core of aging and, as it has been shown in animal models, the removal of senescent cells led to improved fitness and a longer healthspan. One of the hallmarks of aging is a specific pattern of DNA methylation, which has been called the epigenetic clock. Based on selected methylation sites, it is possible to determine the biological age, which indicates the actual age of the organism that may differ significantly from the chronological one. Epigenetic clocks have vital biological significance. They can be used to identify accelerated aging and predict disease risks, including premature death. Such an approach can be a perfect complementary diagnostic tool and a signal to implement countermeasures.
The dynamic interplay between the human microbiomeand aging — implications for health and disease
Authors: Petrazzo Gregory
Published: February 2025

The human microbiome, an intricate ecosystem of microorganisms residing within and on the human body, exerts profound influence on host physiology, metabolism, and immune function. This review explores the multifaceted relationship between the host microbiome and the aging process in the context of rejuvenating therapies. We delve into the shifts in microbial composition and functionality that accompany aging, and their impact on immune homeostasis, nutrient metabolism, and cognitive function. Furthermore, we examine the role of microbiome dysbiosis in age-related diseases, including neurodegenerative disorders, metabolic syndrome, and immunosenescence. A comprehensive understanding of these interactions holds potential for innovative strategies to promote healthy aging and mitigate age-related pathologies.
Krótki zarys długiej historii psychodelików
Authors: Kamińska Kataryzna
Published: February 2025

Psychedelics most likely represent the oldest class of pharmacological compounds used by humans. The origins of the use of these substances will probably never be fully understood by us however, thanks to archaeological findings, we are able to learn about their history. These substances with the ability to induce states of altered perception were used a very long time ago to enhance mystical and religious experiences. They were taken by the Olmecs, Zapotecs, Mayans and Aztecs, among others. Today, in many parts of the world, research is being conducted into the use of psychedelics for a wide variety of medical conditions, but their form and capabilities are closely tied to the legislation of the countries concerned.
INVESTMENT COMPONENT IN THE SYSTEM OF RESTRUCTURING THE NATIONAL ECONOMY
Authors:   Open International University of Human Developmеnt «Ukraine», Ovobyuk V.O.
Published: February 2025

The article reveals the essence and significance of investment restructuring of the national economy as a multifaceted process aimed at modernizing industries, stimulating innovative development and ensuring sustainable economic growth. The role of investment as a key factor of structural changes, which contributes to increasing the competitiveness, balance and adaptability of the national economy to dynamic changes in the global environment, is studied. The main challenges facing the effective attraction of investments are analyzed, among which the instability of the macroeconomic environment, the low level of protection of investor rights and the insufficient development of financial instruments are highlighted. The potential of using digital technologies and environmental investments, which open up new opportunities for stimulating investment activity, increasing the transparency of processes and reducing transaction costs, is assessed.
Implementation of Industry 4.0 principles in the development of agriculture as a tool for capitalization
Authors:   Open International University of Human Developmеnt «Ukraine», Pashinsky A.O. , Shynkareva L.S. ,   Open International University of Human Developmеnt «Ukraine»
Published: February 2025

The article deals with the issue of implementing the principles of Industry 4.0 in the development of agriculture as a tool for capitalization. The authors emphasize that the implementation of Industry 4.0 principles in agriculture opens up new prospects for increasing the capitalization of agricultural enterprises. After all, the use of technologies such as automation, big data, artificial intelligence, robotics, the Internet of Things (IoT), and precision farming systems allows farmers to reduce costs, optimize resource use, and increase productivity. These technologies provide precise monitoring and adaptation to changing field conditions, reduce the cost of fertilizers and energy resources, improving not only production efficiency but also the environmental impact of agricultural processes. In the course of the study, the authors emphasized that the integration of innovative technologies allows agricultural enterprises to increase the added value of their products, which increases their investment attractiveness and contributes to the sustainable development of the regions. The increase in capitalization due to high-tech production also creates new jobs and improves living standards in rural areas, which is an important factor in maintaining the stable development of the national economy. It is proved that the effective implementation of Industry 4.0 in the agricultural sector requires significant investments, including the development of infrastructure for digitalization, stimulation of investment and research activities. It is important to create favorable conditions for small and medium-sized businesses through government support and financial programs that will ensure technological progress at all levels of agricultural production. Thus, the need to capitalize agricultural enterprises by implementing the principles of Industry 4.0 is a key factor for their successful development, increasing their competitiveness in international markets and strengthening Ukraine's economic position on the global stage.
A complexidade de liames entre identidades, diferenças e professores de matemática
Authors: Levy Lênio Fernandes
Published: February 2025

The research described in the pages of this publication was theoretical in nature. We sought to highlight ties between social identities (with emphasis on professional identities) and differences (with regard, in particular, to the identity(ies) of mathematics teachers), using, for this purpose, the philosophical complex perspective by Edgar Morin. Three principles of Morinian complexity theory served as the foundation for the arguments made in the text: the hologrammatic, the dialogical and the recursive. At the end of the study, it was inferred that, when it comes to professionals, in general, and mathematics teachers, in particular: (1) there are different/unusual elements in the identities, (identities) which, with their attributes, are in each of the different/unusual elements that are located in them (hologrammatic ‘complex principle’); (2) identities and differences antagonize and, at the same time, complement each other (dialogical ‘complex principle’); 3) differences generate identities, that react in differences, (re)generating them (recursive ‘complex principle’).