bluuebunny/crossref_metadata_2025 huggingface dataset:
Migration trajectories of seafarers during the transition from sail to steam: Change and continuity in Antwerp, 1850-1900
Authors: Loockx Kristof
Published: October 2020

This article examines the migration trajectories of seafarers who worked on Belgian merchant vessels departing from the port of Antwerp during the second half of the nineteenth century. Based on the Antwerp seamen’s registry, which recorded information on voyages of seafarers on Belgian merchant vessels departing from Belgium’s main commercial port, this article shows that Antwerp’s maritime recruitment area vastly expanded with the advent of steam. The proportion of low-skilled seafarers who originated from inland areas increased as a result of the creation of new departments aboard ship and the emergence of ocean liners. However, established migration fields remained important for the supply of skilled labour in deck departments, which indicates that there was also continuity. The findings suggest that each department had its own dynamics and therefore old and new patterns co-evolved during a period of transition.
On the earliest printed portolano (Venice, 1490)
Authors: Bocchi Andrea
Published: October 2020

In November 1490, Bernardino Rizo da Novara issued the earliest printed anonymous portolano. Several months later, a print privilege was issued at the request of Andrea Badoer, a merchant. With the support of a newly published database of Venetian privileges, it is contended that Badoer sponsored the print and possibly provided the text of the portolano.
Theory and praxis of the professionalisation of the Portuguese navy: The navy officer corps, 1750-1807
Authors: Ortega-del-Cerro Pablo
Published: October 2020

During the second half of the seventeenth century and the first half of the eighteenth century, the most important European monarchies carried out reforms of their navies. Naval officers, who underwent a thorough process of professionalisation – training, education, functions, missions, promotions – were the best exponent of the new idea of the navy being put forward. Portugal was an eminently maritime monarchy, but the professionalisation of the navy did not begin until the second half of the eighteenth century. The reforms culminated in the 1780s and the 1790s, when naval officers and cadets were organised according to a different structure and new regulations were issued. By applying a comparative approach, the central avenue of analysis will be twofold: on one hand, reviewing the theory behind the process; and on the other hand, examining the praxis, in order to determine if these theories were effectively implemented.
Risk Factors for and Outcomes Associated With Peri-Intubation Hypoxemia: A Multicenter Prospective Cohort Study
Authors: Smischney Nathan J. , Khanna Ashish K. , Brauer Ernesto , Morrow Lee E. , Ofoma Uchenna R. , Kaufman David A. , Sen Ayan , Venkata Chakradhar , Morris Peter , Bansal Vikas
Published: October 2020

Background:

Little is known about hypoxemia surrounding endotracheal intubation in the critically ill. Thus, we sought to identify risk factors associated with peri-intubation hypoxemia and its effects’ on the critically ill.

Methods:

Data from a multicenter, prospective, cohort study enrolling 1,033 critically ill adults who underwent endotracheal intubation across 16 medical/surgical ICUs in the United States from July 2015-January 2017 were used to identify risk factors associated with peri-intubation hypoxemia and its effects on patient outcomes. We defined hypoxemia as any pulse oximetry ≤ 88% during and up to 30 minutes following endotracheal intubation.

Results:

In the full analysis (n = 1,033), 123 (11.9%) patients experienced the primary outcome. Five risk factors independently associated with our outcome were identified on multiple logistic regression: cardiac related reason for endotracheal intubation (OR 1.67, [95% CI 1.04, 2.69]); pre-intubation noninvasive ventilation (OR 1.66, [95% CI 1.09, 2.54]); emergency intubation (OR 1.65, [95% CI 1.06, 2.55]); moderate-severe difficult bag-mask ventilation (OR 2.68, [95% CI 1.72, 4.19]); and crystalloid administration within the preceding 24 hours (OR 1.24, [95% CI 1.07, 1.45]; per liter up to 4 liters). Higher baseline SpO2 was found to be protective (OR 0.93, [95% CI 0.91, 0.96]; per percent up to 97%). Consistent results were seen in a separate analysis on only stable patients (n = 921, 93 [10.1%]) (those without baseline hypoxemia ≤ 88%). Peri-intubation hypoxemia was associated with in-hospital mortality (OR 2.40, [95% CI 1.33, 4.31]; stable patients: OR 2.67, [95% CI 1.38, 5.17]) but not ICU length of stay (point estimate 0.9 days, [95% CI −1.0, 2.8 days]; stable patients: point estimate 1.5 days, [95% CI −0.4, 3.4 days]) after adjusting for age, body mass index, illness severity, airway related reason for intubation (i.e., acute respiratory failure), and baseline SPO2.

Conclusions:

Patients with pre-existing noninvasive ventilation and volume loading who were intubated emergently in the setting of hemodynamic compromise with bag-mask ventilation described as moderate-severe were at increased risk for peri-intubation hypoxemia. Higher baseline oxygenation was found to be protective against peri-intubation hypoxemia. Peri-intubation hypoxemia was associated with in-hospital mortality but not ICU length of stay.

Trial registration:

Clinicaltrials.gov identifier: NCT02508948 and Registered Report Identifier: RR2-10.2196/11101.
Beyond Censorship: Polish Independent Press Debates on Claude Lanzmann’s Shoah
Authors: Grądzka-Rejak Martyna , Olaszek Jan
Published: October 2020

The article analyzes discussions around the documentary film Shoah, by Claude Lanzmann, conducted in the uncensored press in communist Poland. In the literature on the subject, a popular thesis claims that the democratic opposition in Poland, like the authorities of the Polish People’s Republic, subjected this film to explicit criticism. The authors’ research into discussions about the Holocaust in the Polish independent press leads to the opposite conclusion.

Ours analysis shows that authors publishing in the underground press had varied reactions to Lanzmann’s film. Voices opposing the official campaign against the director and his film predominate (which did not mean a complete lack of criticism vis-à-vis some of the movie’s features). We found only two opinions that can be considered clearly negative.

The debate about Lanzmann’s film is important because it shows the complexity of the democratic opposition’s attitude of toward Polish-Jewish history and memory. In the opposition elite’s view of history, two currents ran in parallel, often in statements authored by the same people. On the one hand, the trend was primarily affirmative, as a reaction to the communist propaganda that bypassed or completely distorted some aspects of Polish history. On the other hand, there was also a tendency to include more controversial or even clearly shameful aspects of the history of Poland.
Thermally induced postbuckling of thin CNT-reinforced composite plates under nonuniform in-plane temperature distributions
Authors: Trang Le Thi Nhu , Van Tung Hoang
Published: October 2020

This paper presents an analytical investigation on postbuckling behavior of thin plates reinforced by carbon nanotubes (CNTs) and subjected to nonuniform thermal loads. Unlike many previous works considered ideal case of thermal load is that uniform temperature rise, the present study considers more practical situations of thermal load are that sinusoidal and linear in-plane temperature distributions. CNTs are reinforced into matrix through functionally graded distributions and effective properties of nanocomposite are estimated according to extended rule of mixture. Basic equations are based on classical plate theory taking into account Von Karman nonlinearity, initial geometrical imperfection, interactive pressure from elastic foundations and elasticity of tangential constraints of simply supported boundary edges. Basic equations are solved by using analytical solutions and Galerkin method. From the obtained closed-form relations, thermal buckling and postbuckling behavior of nanocomposite plates are analyzed through numerical examples.
How Do Affirmative Action Bans Affect the Racial Composition of Postsecondary Students in Public Institutions?
Authors: Liu Huacong
Published: October 2020

This study investigates the associations between statewide affirmative action bans and the racial composition of undergraduate students at public 4-year colleges and universities in five states, that is, Arizona, Michigan, Nebraska, New Hampshire, and Oklahoma. I use the Integrated Postsecondary Education Data System data from 1999 to 2017, and find that despite having few selective postsecondary institutions, public four-year institutions in these five states experienced an average decline of 0.42 percentage points in the enrollment of underrepresented racial-ethnic minority students following bans on affirmative action. Further, the bans also decreased the enrollment of underrepresented racial-ethnic minority students at four state public flagship universities.
Analytical procedures for determining global minimum friction requirement for a six wheeled rover negotiating hard uneven terrain
Authors: Noble Sam , Kurien Issac K
Published: October 2020

The problem of determining wheel torques of a rover, to minimize friction requirement, has been addressed by many researchers. We address it by trying to understand the ways in which local optima can occur, and on the basis of that understanding, develop analytical and non-iterative algorithms for determining global optima. The problem is posed in two variations, with normal reaction forces on wheels bounded below by (a) zero, and (b) a positive limit. In both cases, the nature of optima is studied comprehensively, and illustrated by solving examples. Explicit expressions are used to find roots of up to a cubic polynomial. Our algorithms are on the average about an order of magnitude faster than an SQP based general optimization solver, when the latter is started from random guesses. Moreover, our algorithms were able to reach global minima without fail for all examples solved, which number more than a thousand.
Increasing HIV prevalence and injection drug use among men who have sex with men in Ho Chi Minh City, Vietnam
Authors: Tuan Nguyen Anh , Johnston Lisa G , Thanh Duong Cong , Le Linh-Vi N , Hoang Tran Vu , Quang Tran Dai , Quoc Nguyen Cuong , Nadol Patrick , Hien Nguyen Tran , Abdul-Quader Abu
Published: October 2020

Vietnam has been conducting HIV/sexually transmitted infection (STI) integrated bio-behavioral surveillance surveys on men who have sex with men (MSM) as well as other key populations since 2005. Although HIV prevalence in the Vietnamese general population remains below 1%, it is expected to be much higher among MSM.

Data on HIV prevalence and sexual and drug use behaviors were collected from MSM in Ho Chi Minh City (HCMC) in 2006 (n = 397), 2009 (n = 399) and 2013 (n = 350) using respondent-driven sampling. Eligible participants were males, aged ≥15 years who reported having manual, oral, or anal sexual activity with males in the past year and lived, worked or socialized in HCMC.

HIV seroprevalence among MSM was 5.8% in 2006, 16.1% in 2009 and 12.1% in 2013 and prevalence of at least one STI (syphilis, gonorrhea and/or chlamydia infection) was 11.4% in 2006 and 15.6% in 2009 (no data for 2013). Significant, but small, increasing trends were found for MSM who reported ever testing and receiving results for HIV and for HIV prevalence. No significant changes for condom use, injecting and non-injecting drug use, or and receipt of free condoms were observed.

Although a small percentage of MSM reported injecting drugs, HIV was positively associated with ever injecting drugs. Programs targeting MSM should include screening and treatment for injection drug use to most effectively control the HIV/AIDS epidemic among MSM in HCMC.
Gonorrhea testing, morbidity, and reporting using an integrated sexually transmitted disease registry in Indiana: 2004–2016
Authors: Ojo Opeyemi C , Arno Janet N , Tao Guoyu , Patel Chirag G , Zhang Zuoyi , Wang Jane , Holderman Justin , Dixon Brian E
Published: October 2020

Surveillance of gonorrhea (GC), the second most common notifiable disease in the United States, depends on case reports. Population-level data that contain the number of individuals tested in addition to morbidity are lacking. We performed a cross-sectional analysis of data obtained from individuals tested for GC recorded in a sexually transmitted disease (STD) registry in the state of Indiana. Descriptive statistics were performed, and a Poisson generalized linear model was used to evaluate the number of individuals tested for GC and the positivity rate. GC cases from a subset of the registry were compared to CDC counts to determine the completeness of the registry. A total of 1,870,811 GC tests were linked to 627,870 unique individuals. Individuals tested for GC increased from 54,334 in 2004 to 269,701 in 2016; likewise, GC cases increased from 2,039 to 5,997. However, positivity rate decreased from 3.75% in 2004 to 2.22% in 2016. The difference in the number of GC cases captured by the registry and those reported to the CDC was not statistically significant (P = 0.0665). Population-level data from an STD registry combining electronic medical records and public health case data may inform STD control efforts. In Indiana, increased testing rates appeared to correlate with increased GC morbidity.
Prediction of critical heat flux in flow boiling process under the effect of different operating parameters
Authors: Abedini Ehsan , Behboudi Mohammad , Mohammadi Karachi Arash , Hamidi Jahromi Reza , DolatiAsl Kianoush
Published: October 2020

In the present study numerical simulation of flow boiling process has been conducted for evaluation of critical heat flux conditions under the effect of different parameters (mass flux, heat flux, channel length and surface roughness). Comparison between the results of the present study and previous researches were done. The comparison shows a good agreement between the present study and previous researches. The three different turbulence models (k-epsilon, k-omega and Reynolds Stress) are considered for simulation of boiling heat transfer and CHF phenomenon. The highest accuracy of simulation is obtained by k-epsilon model. The results express that the wall temperature value of tube with adiabatic and heated boundary conditions for first and second half of the tube is lower than the wall temperature when the fluid flows only in the heated wall section. Reduction of velocity value also leads to reduction of maximum wall temperature value and CHF value. Decreasing Roughness value as an effective parameter leads to an increase in wall temperature. Maximum value of the wall temperature, after CHF point, also increases with increase in heat flux value. CHF depends on the surface roughness and rises with increasing roughness value.
Just transition on the ground: Challenges and opportunities for social dialogue
Authors: Galgóczi Béla
Published: October 2020

The process leading to a net zero carbon economy by mid-century will have massive effects on jobs, labour relations and income distribution. The idea of just transition – that achieving the ambitious objectives to bring climate change under control will only be possible if the transition to a net-zero carbon economy is balanced and just – has evolved in the last four decades from a union initiative to a complex policy framework adopted by international organizations, and also referred to in the COP21 Paris Agreement (UNFCCC, 2015). Building on literature analysis, this article deconstructs the concept of ‘just transition’ by discussing its various interpretations and dimensions and highlighting the role of trade unions in applying it. Based on sectoral case studies, concrete examples from two key sectors of the European economy – energy and automobile – are given, where massive employment transitions are under way and social dialogue plays a key role. Conclusions about the changing role of trade unions and the importance of co-operative industrial relations are drawn.
Innovating for energy efficiency: Digital gamification in the European steel industry
Authors: Stroud Dean , Evans Claire , Weinel Martin
Published: October 2020

The European steel industry, as an energy intensive industry, has significant concerns over energy efficiency and compliance with EU environmental regulations. Hence, across the industry, energy efficiency is a key area of innovation activity. However, responding to climate change measures and finding efficiency gains by technological means is becoming increasingly difficult and so managements are turning attention to modifying, that is, ‘greening’ worker behaviours. Here, we focus on an innovation that combines a digital technology application with a management strategy, that is, gamification for energy efficiency behaviour modification. Drawing on data from a project involving steel plants in Germany, Norway and the UK, we adopt an international comparative approach to examine the implications of differing industrial relations contexts for shaping steel firm engagement with ‘green’ innovations.
Altered oxidative stress markers in relation to T cells, NK cells & killer immunoglobulin receptors that are associated with disease activity in SLE patients
Authors: Tandon Ankit , Anupam Kumari , Kaushal Jyotsana , Gautam Preeti , Sharma Aman , Bhatnagar Archana
Published: October 2020

Systemic Lupus Erythematosus is an autoimmune disease with symptoms pervasive to all organ systems. It affects more females as compared to males (in the ratio 9:1). Oxidative stress plays a major role in the pathogenesis of SLE and other autoimmune diseases. In order to understand the relationship between cell specific oxidative stress and the severity of SLE, this research study involving the estimation of intracellular ROS accumulation in T and NK cell was conducted on SLE patients of North Indian Population. At the same time, to estimate anti-oxidant defense, Keap1 and Nrf2 levels were estimated in these cell types. The relationship between the expression of Killer immunoglobulin receptors i.e., KIR2DL4 & KIR3DL1 and oxidative stress was also evaluated as these receptors are imperative for the function and self-tolerance of NK cells.

Oxidative stress was raised along with Keap1 and Nrf2 in T and NK cell subsets in SLE patients. The expression of KIR2DL4 was raised and that of KIR3DL1 was reduced in the NK cells of patients. The intensity of change in expression and its significance varied among the subsets. Nrf2 expression was raised in these species against oxidative stress as the antioxidant defense mechanism pertaining to Keap1-Nrf2 pathway, but the adequacy of response needs to be understood in further studies. The expression of KIR2DL4 and KIR3DL1 varied among the patient and healthy controls and the expression of the latter was found to have a significant positive relationship with plasma Glutathione(reduced) concentration.
Is There Preclinical and Clinical Value for 19F MRI in Stem Cell Cardiac Regeneration?
Authors: Constantinides Christakis
Published: October 2020

Cardiovascular regeneration aims to renew damaged or necrotic tissue and to enhance cardiac functional performance. Despite the hope arisen from the introduction and use of stem cells (SCs) as a novel cardiac regenerative approach, to-this-date, clinical trial findings are still ambivalent despite preclinical successes. Concurrently, noninvasive magnetic resonance imaging (MRI) advances have been based on nanotechnological breakthroughs that have (a) allowed fluorinated nanoparticles and ultrasmall iron oxide single-cell labeling, (b) explored imaging detection sensitivity limits (for preclinical/low-field clinical settings), and (c) accomplished cellular tracking in vivo. Nevertheless, outcomes have been far from ideal. Herein, the recently developed preclinical and clinical 1H and 19F MRI approaches for direct cardiac SC labeling techniques intended for cellular implantation and their potential for tracking these cells in health and infarcted states are summarized. To this extent, the potential preclinical and clinical values of 19F MRI and tracking of SCs for cardiac regeneration in myocardial infarction are questioned and challenged.
Predicting terpene content in dried conifer shoots using near infrared spectroscopy
Authors: Champagne Emilie , Bonin Michaël , Royo Alejandro A , Tremblay Jean-Pierre , Raymond Patricia
Published: October 2020

Terpenes are phytochemicals found in multiple plant genera, especially aromatic herbs and conifers. Terpene content quantification is costly and complex, requiring the extraction of oil content and gas chromatography analyses. Near infrared (NIR) spectroscopy could provide an alternative quantitative method, especially if calibration can be developed with the spectra of dried plant material, which are easier and faster to acquire than oil-based spectra. Here, multispecies NIR spectroscopy calibrations were developed for total terpene content (mono- and sesquiterpenes) and for specific terpenes (α-pinene, β-pinene and myrcene) with five conifers species ( Picea glauca, Picea rubens, Pinus resinosa, Pinus strobus and Thuja occidentalis). The terpene content of fresh shoot samples was quantified with gas chromatography. The NIR spectra were measured on freeze-dried samples (n = 137). Using a subset of the samples, modified partial least squares regressions of total terpene and the three individual terpenes content were generated as a functions of the NIR spectra. The standard errors of the internal cross-validations (values between 0.25 and 2.28) and the ratio of prediction to deviation ratios (RPD values between 2.20 and 2.38) indicate that all calibrations have similar accuracy. The independent validations, however, suggest that the calibrations for total terpene and α-pinene content are more accurate (respective coefficient of determination: r2 = 0.85 and 0.82). In contrast, calibrations for β-pinene and myrcene had a low accuracy (respectively: r2 = 0.62 and 0.08), potentially because of the low concentration of these terpenes in the species studied. The calibration model fits (i.e., r2) are comparable to previously published calibration using the spectra of dried shoot samples and demonstrate the potential of this method for terpenes in conifer samples. The calibration method used could be useful in several other domains (e.g. seedling breeding program, industrial), because of the wide distribution of terpenes and especially of pinenes.
Ethical dilemmas, perceived risk, and motivation among nurses during the COVID-19 pandemic
Authors: Sperling Daniel
Published: October 2020

Background:

Positioned at the frontlines of the battle against COVID-19 disease, nurses are at increased risk of contraction, yet as they feel obligated to provide care, they also experience ethical pressure.

Research question and objectives:

The study examined how Israeli nurses respond to ethical dilemmas and tension during the COVID-19 outbreak, and to what extent this is associated with their perceived risk and motivation to provide care?

Research design:

The study implemented a descriptive correlative study using a 53-section online questionnaire, including 4 open-ended questions.

Participants and research context:

The questionnaire was complete by 231 registered and intern nurses after being posted on nurses’ Facebook and WhatsApp groups, and through snowball sampling.

Ethical considerations:

The research was pre-approved by the ethics committee of the Faculty of Social Welfare and Health Sciences at the University of Haifa, Israel.

Findings:

In all, 68.8% of the respondents had received some form of training about COVID-19. Respondents positioned themselves at perceived high risk levels for contracting the virus. About one-third feared going to work because of potential contraction and due to feeling inadequately protected. While 40.9% were scared to care for COVID-19 patients, 74.7% did not believe they have the right to refuse to treat certain patients. When asked about defining an age limit for providing patients with scarce resources (such as ventilation machines) in cases of insufficient supplies, respondents stated that the maximum age in such scenarios should be 84 (standard deviation (SD = 19) – yet most respondents (81.4%) believed that every patient has the right to receive optimal treatment, regardless of their age and medical background.

Discussion:

Correlating with their strong commitment to care, nurses did not convey intention to leave the profession despite their stress, perceived risk, and feelings of insufficient support and protection at work. The nurses did not hold a utilitarian approach to resource allocation, thereby acknowledging the value of all people and their entitlement to care, regardless of optimal outcomes.

Conclusion:

While experiencing significant personal risk and emotional burden, nurses conveyed strong dedication to providing care, and did not regret working in the nursing profession, yet they did seek a supportive climate for their needs and ethical concerns.
The My Children’s Future Scale: Construct validity, measurement invariance, and reliability in a Turkish sample
Authors: Esen Erol
Published: October 2020

The My Children’s Future Scale (MCFS) measures the support provided by parents for their children’s careers. The aim of this study was to adapt the MCFS to Turkish and examine its psychometric characteristics in a study conducted in the Turkish context. Participants consisted of 280 parents (190 mothers and 90 fathers). The factor structure of the MCFS and measurement invariance across parent gender were examined. The unidimensional factor structure was confirmed and the scale was invariant across parent gender. In addition, the reliability of the MCFS was assessed for internal consistency and test-retest reliability. Cronbach’s alpha and McDonald’s omega coefficients were calculated as .87, and test-retest reliability coefficient as .83. Our findings suggested that the Turkish form of the MCFS can be considered a valid and reliable data collection tool for use in Turkey to measure the support provided by parents for their children’s careers.
Thinking about parents and infants – finding a home for perinatal and infant psychiatry
Authors: Newman AM Louise
Published: October 2020

Objectives:

To describe current issues facing the field of perinatal and infant psychiatry, the issues involved in developing service models and greater awareness of the area in mental health service strategic development. To describe contemporary approaches working to integrate perinatal and infant models with a focus on early-in-life intervention and prevention.

Conclusions:

Perinatal and infant psychiatry has ongoing issues in clarifying the location of services and their models of care with a lack of clear higher level governance. It remains a vital area for improving the mental health of both carers and infants and child development.
Granulomatous polyarthritis caused by Talaromyces georgiensis in a dog
Authors: Okada Kazuki , Kano Rui , Hasegawa Takehiro , Kagawa Yumiko
Published: October 2020

A 6-y-old, 3.5-kg, spayed female Toy Poodle was presented with left forelimb lameness of 2-d duration. Two months before the initial presentation, radiography showed osteolysis of the medial epicondyle of the left humerus, and the left forelimb was amputated. Grossly, the articular villi of the elbow joint were markedly thickened, and the articular cartilage surfaces of the distal humerus and proximal radius had partial erosion. Histologically, granulomatous arthritis and osteomyelitis characterized by the presence of abundant macrophages containing numerous fungi were observed. ITS and β-tubulin sequences amplified from the isolate from the specimen were 100% and 99% identical to type strain UTHSC D16-145T of Talaromyces georgiensis, respectively. Canine osteoarthritis caused by T. georgiensis has not been reported previously, to our knowledge.
Resection of a Posterior Mediastinal Mass in a 4-Year-Old Child Complicated by Difficult Airway Management and Emergent Use of Extracorporeal Membrane Oxygenation
Authors: Au Valerie , Marsh Benjamin , Benkwitz Claudia
Published: October 2020

Literature on posterior mediastinal masses is limited. Furthermore, they have traditionally been described to pose lower cardiopulmonary risks compared with anterior mediastinal masses. Studies on posterior mediastinal masses are even more limited in the pediatric population. We present a case of a large posterior mediastinal mass in a 4-year-old child who presented with extremely difficult airway management during endobronchial intubation due to severe external compression that led to use of an adapted airway management technique with a rigid airway exchanger for lung isolation. Due to the pathology of the mass, a tracheal tear was encountered during surgical dissection and the patient required emergent venovenous extracorporeal membrane oxygenation to allow for successful airway repair and complete resection of the mass.
Experimental and numerical study of auxetic sandwich panels on 160 grams of PE4 blast loading
Authors: Arifurrahman Faizal , Critchley Richard , Horsfall Ian
Published: October 2020

Mines, specifically as Anti-Tank (AT) mines are a significant threat for defence vehicles. While approaches such as v-shaped hulls are currently used to deflect the blast products from such threats, such a solution is not always usable when hull standoff is limited. As such the development of a low profile, energy absorbing solution is desirable. One approach that has potential to achieve these requirements are sandwich panels. While sandwich panel cores can be constructed from various materials, one material of particular interest are auxetics. Auxetic are materials that exhibit a negative Poisson’s ratio. This material has potential to be an efficient an impact energy absorber by increasing stiffness at local deformation by gathering mass at the impact location. This study investigates the effectiveness of novel auxetic core infills alongside three other panel types (monolithic, air gap, polymer foam sandwich) against buried charges. 160 grams of PE4 were buried in 100 mm depth and 500 mm stand off the target. Laser and High Speed Video (HSV) system were used to capture the deflection-time profile and load cell sensors were used to record the loading profile received by the panels. Experimental works were compared with numerical model. Explicit model were generated in LSDYNA software as ‘initial impulse mine’ keyword. The result found that the auxetic and foam core panels were effective in reducing peak structural loading and impulse by up to 33% and 34% respectively. Air-filled panels were the most effective to reduce the deflection of the rear of the plate, however variation between capture methods (HSV and Laser system) were reported, while numerical modelling provided comparable plate deflections responses. When normalised against panel weight, the air filled panels were experimentally the most efficient per unit mass system with the auxetics being the least effective.
Lyme disease atypically presenting with a singular symptom: Unilateral chorioretinitis
Authors: Havuz Erol , Güdül Havuz Seda
Published: October 2020

Background:

Lyme disease, caused by Borrelia burgdorferi, is a spirochetal disease. Lyme disease-related ocular findings may also provide important clues. Ocular involvement is most commonly seen as uveitis, chorioretinitis, conjunctivitis, keratitis, episcleritis, papillitis, panuveitis, ischemic optic neuropathy, papilledema, and retinal vasculitis.

Case:

A 27-year-old male patient was admitted with a history of fatigue, malaise, and sudden loss of vision in his left eye for 3 days. The best visual acuity was found 20/20 in the right eye and 20/400 in the left eye. Fluorescein fundus angiography showed no pathological findings in the right eye; but hyperfluorescence that was compatible with choroiditis foci was seen in the left eye. Optical coherence tomography (OCT) showed choroidal thickening in the left eye compared to the right eye. Lyme IgM antibody was found to be positive, explaining choroiditis etiology, while IgG values were found to be negative. Western blot verification test was positive. The patient was treated with 2 × 100 mg doxycycline (21 days) with a diagnosis of Lyme disease, prednol 1 mg/kg/day (10 days) for choroiditis. Omeprazole tablets were given 1 × 1 during the period of cortisone intake. On the third day of treatment, visual acuity increased to 20/200 and continued to increase until reaching 20/20 in the second week.

Conclusions:

Lyme disease is rare, but must be kept in mind when investigating the etiology of chorioretinitis and retinal vasculitis. The patient reported here is, to our knowledge, the second case reported in literature that shows atypical clinic for Lyme disease with unilateral chorioretinitis without Erythema chronicum migrans (ECM).
Atopic objects: The afterlives of gold teeth stolen from Holocaust dead
Authors: Dziuban Zuzanna
Published: October 2020

Transfers of property are an integral part of armed conflicts and instances of mass political violence. Not just the state and the military, but also civilians confiscate, dispossess, loot and redistribute wealth across ethnic, national, class or religious lines, in the process re-enacting and sustaining the boundaries of othering and belonging that stand behind the conflict. In this way, economic violence takes on an essentially political dimension. Although, to date, rarely conceptualized as such, even grave robbery perpetrated at the burial sites of a defeated enemy or a member of othered minority constitutes a practice of alterity and dehumanization. And while, in the aftermath of violence, this very fact has the ability to invest things taken from mass graves with a particularly disturbing potential, this article reflects on the practices and affective dynamics surrounding objects of a distinctively unsettling status: golden teeth and dental bridges in their ambivalent condition between material objects (valuables) and bodily remains of the dead. They are considered in this article through the conceptual lens of ‘atopic objects’, a notion designed to bring to the fore both the out-of-place quality and the at once as-well-as/neither-nor character of those things, suspended on the threshold between human remains and material objects, private possessions and body parts of othered and violently dispossessed people. In this article, the author asks how this uneasy ontological status is experienced, acted upon and negotiated by the new (and rarely rightful) ‘owners’ and offers an insight into the practical, affective, political and also legal framings through which ‘atopic objects’ are being constructed and reconstructed either as things or as body parts and, at the cost of their unsettling quality, become embedded in the postwar orders, both in the intimate order of the body and in the political–economic order of the state.
“What’s going on” in Ferguson? Online news frames of protest at the police killing of Michael Brown
Authors: Riddle Travis A. , Turetsky Kate M. , Bottesini Julia G. , Wayne Leach Colin
Published: October 2020

Public reactions to protests are often divided, with some viewing the protest as a legitimate response to injustice and others perceiving the protest as illegitimate. We examine how online news sources oriented to different audiences frame protest, potentially encouraging these divergent reactions. We focus on online news coverage following the 2014 police shooting of a Black teenager, Michael Brown. Preregistered analyses of headlines and images and their captions showed that sources oriented toward African Americans were more likely to include content conveying racial injustice and legitimacy of the subsequent protests than sources oriented toward a general audience. In contrast, general audience sources emphasized conflict between protesters and police, making fewer references to the protesters’ cause. Whereas much work on media segregation addresses the propensity of audiences to consume different sources, our work suggests that news sources may also contribute to information fragmentation by differentially framing the same events.
Requests and know-how questions: Initiating instruction in workplace interaction
Authors: Risberg Jonas , Lymer Gustav
Published: October 2020

While it is recognized that instruction between co-workers is a central component of everyday workplace interaction and learning, this study investigates the ways in which such instructional events are practically initiated in interaction. We analyse recordings of everyday work at a radio station, where journalists prepare and broadcast local news. In our data, a distinction can be made between two interactional contexts from which instructional interactions emerge: searches, where one party is looking for a suitable helper; and established interactions, where the initiation of instruction is prefigured by immediate prior interaction. A further finding is that these two contexts are associated with two different ways of initiating instruction. Direct requests are used in established interactions. In searches, we instead find questions regarding the other person’s procedural knowledge – what we term know-how questions. We finally discuss the ways in which instructional configurations are assembled without reference to institutionally defined instructor/instructed roles.
Depression, perceived stress related to COVID, post-traumatic stress, and insomnia among asthma and COPD patients during the COVID-19 pandemic
Authors: Pedrozo-Pupo John Carlos , Campo-Arias Adalberto
Published: October 2020

Introduction:

The COVID pandemic has had a high psychological impact on healthy populations. Increased levels of perceived stress, depression, and insomnia are expected, especially in people with pre-existing medical conditions, such as asthma and chronic obstructive pulmonary disease (COPD), who seem to be particularly vulnerable. However, the difference in psychological distress frequency between asthma and COPD patients is unknown.

Objective:

To compare the prevalence of depression, perceived stress related to COVID, post-traumatic stress, and insomnia in asthma and COPD patients at a pulmonology clinic in Santa Marta, Colombia.

Methods:

A cross-sectional study was designed. The patients were contacted by telephone. An electronic link was sent to those who accepted. The questionnaire asked for perceived stress related to COVID-19, post-traumatic stress symptoms, depressive symptoms, and insomnia risk.

Results:

148 asthma patients and 144 COPD patients participated in, between 18 and 96 years. The prevalence of high COVID-19 perceived stress was 10.6% (n = 31); post-traumatic stress risk, 11.3% (n = 33); depression risk, 31.5% (n = 92); and insomnia risk, 57.7% (n = 169). No significant differences were found between asthma and COPD in indicators of psychological distress.

Conclusions:

Asthma and COPD patients present similar frequencies of depression risk, COVID-19 perceived stress, post-traumatic stress risk, and insomnia risk during the Colombian lockdown. It is essential to evaluate and manage psychological distress among asthma and COPD patients. It can reduce the risk of exacerbation and improve the quality of life.
Alternative Ways of Capturing the Legacies of Traumatic Events: A Literature Review of Agency of Children Living in Countries Affected by Political Violence and Armed Conflicts
Authors: Cavazzoni Federica , Fiorini Alec , Veronese Guido
Published: October 2020

Background:

It has been revealed that the construct of agency plays a crucial role in contributing to children’s positive functioning and well-being despite their traumatic contexts. Yet there is little agreement within the literature about the definition of agency, how agency is displayed by children, or how it should be investigated.

Aims:

This study provides a synthetic overview of studies that have analyzed the agency of children living in contexts affected by political violence and armed conflict. In the process, it highlights major theoretical breakthroughs and findings in this area of research. The aim was to review research investigating the different ways in which children’s agency manifests itself within their everyday lives, as well as possible policy implications.

Method:

We identified published peer-reviewed studies relating to children’s agency in conflict-affected environments through a narrative literature review. An ecological framework was used to organize studies according to the different settings (personal, familial, cultural, or contextual) within which the children’s agency was displayed.

Results:

Of 682 studies identified from online searches of the literature and the three additional sources gathered through bibliography mining, 63 qualified for full review, with 15 studies included in the final synthesis. Overall, the literature focused mostly on the ways in which children’s ability to mobilize resources emerged in order to cope with their challenging contexts.

Conclusion:

Scholars advocated for community-oriented and child-centered programs that are aimed not only at promoting recovery from symptoms but also at fostering advocacy and a sense of agency in children.
Pandemics and Partisanship: Following Old Paths into Uncharted Territory
Authors: Fowler Luke , Kettler Jaclyn J. , Witt Stephanie L.
Published: October 2020

Although partisan politics tend be set aside during crisis, the timing of gubernatorial actions in response to COVID-19 is telling about how partisanship is shaping the way elected officials are reacting to this pandemic. Using an event history analysis, the authors find that Democratic governors responded to the White House’s attempts to downplay the severity of the pandemic by declaring emergencies in order to draw citizen attention to and to prepare for a public health crisis. On the other hand, Republican governors resisted doing so until Trump declared a national emergency on March 13; however, Republican reactions were conditional on the president’s job approval in their states. While the COVID-19 pandemic has pushed governments into uncharted territory, state governors appear to be following patterns of vertical partisan competition that mirror those of more conventional policy areas in recent years.
Down-Regulation of AHNAK2 Inhibits Cell Proliferation, Migration and Invasion Through Inactivating the MAPK Pathway in Lung Adenocarcinoma
Authors: Wang Dong-Wei , Zheng Hai-Zheng , Cha Na , Zhang Xiao-Jie , Zheng Min , Chen Ming-Ming , Tian Li-Xiang
Published: October 2020

AHNAK nucleoprotein 2 (AHNAK2) has been emerged as a crucial protein for neuroblast differentiation and cell migration, thereby involving in the development of various cancers. However, the specific molecular mechanism of AHNAK2 in lung adenocarcinoma is inconclusive. By accessing to the Oncomine dataset and GEPIA website, a higher expression level of AHNAK2 was observed in lung adenocarcinoma tissue samples. Overall survival (OS) curve plotted by Kaplan-Meier method showed that up-regulation of AHNAK2 was related with poor prognosis of lung adenocarcinoma patients. Quantitative reverse transcription polymerase chain reaction (qRT-PCR) analysis and western blot were conducted to examine the expression level of genes in lung adenocarcinoma cells. Through functional in vitro experiments, cell proliferation, migration and invasion were all suppressed after AHNAK2 knockdown using Cell counting kit-8 (CCK-8) assay, wound-healing and transwell analysis. Reduction of AHNAK2 decreased the apoptosis rate using flow cytometry analysis. Moreover, the key markers of MAPK pathway, p-MEK, p-ERK and p-P90RSK were decreased due to the transfection of si-AHNAK2 in A549 cells. U0126, a MEK inhibitor, showed the similar effects on MAPK-related protein levels with si-AHNAK2. To sum up, AHNAK2 is significantly increased in lung adenocarcinoma and plays a carcinogenic role by activating the MAPK signaling pathway, providing a novel insight and raising possibility for lung adenocarcinoma treatment.
Comprehensive Characterization of Circular RNAs in Neuroblastoma Cell Lines
Authors: Zhang Li , Zhou Hangyu , Li Jing , Wang Xinyu , Zhang Xin , Shi Tieliu , Feng Guoshuang
Published: October 2020

Neuroblastoma (NB) is a rare type of cancer but frequently occurred in children. However, it is still unclear whether circular RNAs (circRNAs) play key roles in NB tumorigenesis or progression. In this study, we identified 39,022 circRNAs across the 39 neuroblastoma and 2 normal cell lines. With the gene and circRNA expression data, we classified the NB cell lines, identified and characterized the functional circRNAs in the 3 NB classes. Specifically, 29 circRNAs were found to be dysregulated in the NB classes. Notably, 7 circRNAs located within MYCN-amplified regions were upregulated in cell lines with the high activities of MYC targets and MYCN amplification, and were highly correlated with expression of their parental gene, NBAS. Subsequently, we constructed ceRNA networks for the functional circRNAs. Specifically, hsa_circ_0005379 was identified as a critical regulator in the ceRNA networks because of targeting 13 genes, which formed a complex competing endogenous RNA (ceRNA) network. Moreover, hsa_circ_0002343, which was connected with few genes, might regulate the PI3K/Akt/mTOR signaling via RAC1. Furthermore, 3 genes, including NOTCH2, SERPINH1, and LAMC1, involved in epithelial mesenchymal transition (EMT) were observed to connect with hsa_circ_0001361, suggesting that this circRNA was closely associated with EMT. Consequently, 7 genes, such as DAD1, PPIA, NOTCH2, PGK1, BUB1, EIF2S1, and TCF7L2, were found to be closely associated with both event-free survival (EFS) and overall survival (OS). In conclusion, the present study identified functional circRNAs and predicted their functionality in neuroblastoma cell lines, which not only improved the understanding of circRNAs in neuroblastoma, but also provided the evidences for the related researchers.
Phosphorylation of CREB-Specific Coactivator CRTC2 at Ser238 Promotes Proliferation, Migration, and Invasion of Colorectal Cancer Cells
Authors: Wang Yi , Liu Qian , Zhang Hanshuo
Published: October 2020

cAMP response element binding protein (CREB)-regulated transcription coactivator 2 (CRTC2), a member of the novel CRTC family of transcriptional coactivators that activates basic leucine zipper transcription factors, including CREB, is overexpressed in many carcinomas, including colon cancer. Phosphorylation of CRTC2 protein at different residues is important for its subcellular localization and activity. However, the functions of some of the serine phosphorylation sites have not been elucidated. This study aimed to investigate the effects of phosphorylation of Ser127, Ser238, and Ser245 sites of CRTC2 in colorectal cancer (CRC) cells. Recombinant lentiviral particles with a CRTC2-targeting small hairpin RNA (shRNA) sequence were transfected into CRC cells to obtained shCRTC2 cell lines. Site-directed mutagenesis of Ser127, Ser238, and Ser245 cells were constructed by transfecting CRTC2 cDNA containing S127A, S238A, and S245A mutations into shCRTC2. Cell proliferation was measured by cell counting kit-8. Cell migration and invasion were examined by transwell assay. mRNA expression was assayed by qRT-PCR, and protein expression was determined by Western blot. Our results indicate that CRTC2 is overexpressed in CRC cells. Knockdown of CRTC2 inhibits the proliferation, migration, and invasion of CRC cells. When the phosphorylation of CRTC2 Ser238 decreases due to the lack of ERK2, the phosphorylation of Ser171 site increases. The proliferation, migration and invasion of CRC cells were inhibited, the nuclear aggregation of CRTC2 in the nucleus was reduced, and the interaction between CRTC2 and CREB was weaken. It is shown that the phosphorylation of CRTC2 Ser238 is important for CREB transcriptional activity. These findings may help in the identification of potentially new targets for CRC therapy.