bluuebunny/crossref_metadata_2025 huggingface dataset:
Subjective Measurements of In-Flight Sleep, Circadian Variation, and Their Relationship with Fatigue
Authors: van den Berg Margo J. , Wu Lora J. , Gander Philippa H.
Published: September 2016

BACKGROUND: This study examined whether subjective measurements of in-flight sleep could be a reliable alternative to actigraphic measurements for monitoring pilot fatigue in a large-scale survey.METHODS: Pilots (3-pilot crews) completed a 1-page survey on outbound
and inbound long-haul flights crossing 1–7 time zones (N = 586 surveys) between 53 city pairs with 1-d layovers. Across each flight, pilots documented flight start and end times, break times, and in-flight sleep duration and quality if they attempted sleep. They also rated their
fatigue (Samn-Perelli Crew Status Check) and sleepiness (Karolinska Sleepiness Scale) at top of descent (TOD). Mixed model ANCOVA was used to identify independent factors associated with sleep duration, quality, and TOD measures. Domicile time was used as a surrogate measure of circadian phase.RESULTS:
Sleep duration increased by 10.2 min for every 1-h increase in flight duration. Sleep duration and quality varied by break start time, with significantly more sleep obtained during breaks starting between (domicile) 22:00–01:59 and 02:00–05:59 compared to earlier breaks. Pilots
were more fatigued and sleepy at TOD on flights arriving between 02:00–05:59 and 06:00–09:59 domicile time compared to other flights. With every 1-h increase in sleep duration, sleepiness ratings at TOD decreased by 0.6 points and fatigue ratings decreased by 0.4 points.DISCUSSION:
The present findings are consistent with previous actigraphic studies, suggesting that self-reported sleep duration is a reliable alternative to actigraphic sleep in this type of study, with use of validated measures, sufficiently large sample sizes, and where fatigue risk is expected to be
low.van den Berg MJ, Wu LJ, Gander PH. Subjective measurements of in-flight sleep, circadian variation, and their relationship with fatigue. Aerosp Med Hum Perform. 2016; 87(10):869–875.
Elevated End-Tidal Pco2 During Long-Duration Spaceflight
Authors: Hughson Richard L. , Yee Nicholas J. , Greaves Danielle K.
Published: September 2016

BACKGROUND: Elevated ambient Pco2 in the International Space Station (ISS) has been cited as a potential contributor to the vision impairment intracranial pressure syndrome (VIIP), a significant health risk for astronauts during long-duration space missions. The elevation
in ambient Pco2 is rather modest and normal respiratory compensation could minimize the impact on arterial Pco2.METHODS: In nine male astronauts, breaths measured prior to a rebreathing maneuver were examined to assess inspired and end-tidal Pco2
during upright seated preflight and in-flight conditions.RESULTS: Inspired Pco2 increased from preflight baseline (0.6 ± 0.1 mmHg) to in flight (3.8 ± 0.4 mmHg). End-tidal Pco2 also increased from preflight baseline (36.0 ± 3.2 mmHg) to
in flight (42.1 ± 3.7 mmHg). The difference between end-tidal Pco2 comparing in flight to preflight (6.1 ± 1.6 mmHg) was greater than the difference between inspired Pco2 comparing preflight to in flight (3.3 ± 0.5 mmHg).DISCUSSION: The
greater increase in end-tidal vs. inspired Pco2 might reflect alveolar hypoventilation due to differences in ventilatory control with spaceflight. These data suggest that further studies should focus on arterial Pco2 and acid-base balance to determine if CO2
dilates cerebral and retinal vessels and might contribute to the incidence of VIIP in astronauts.Hughson RL, Yee NJ, Greaves DK. Elevated end-tidal Pco2 during long-duration spaceflight. Aerosp Med Hum Perform. 2016; 87(10):894–897.
Spatial Disorientation Training in the Rotor Wing Flight Simulator
Authors: Powell-Dunford Nicole , Bushby Alaistair , Leland Richard A.
Published: September 2016

BACKGROUND: This study is intended to identify efficacy, evolving applications, best practices, and challenges of spatial disorientation (SD) training in flight simulators for rotor wing pilots.METHODS: Queries of a UK Ministry of Defense research database and Pub
Med were undertaken using the search terms ‘spatial disorientation,’ ‘rotor wing,’ and ‘flight simulator.’ Efficacy, evolving applications, best practices, and challenges of SD simulation for rotor wing pilots were also ascertained through discussion with
subject matter experts and industrial partners. Expert opinions were solicited at the aeromedical physiologist, aeromedical psychologist, instructor pilot, aeromedical examiner, and corporate executive levels.RESULTS: Peer review literature search yielded 129 articles, with 5 relevant
to the use of flight simulators for the spatial disorientation training of rotor wing pilots. Efficacy of such training was measured subjectively and objectively. A preponderance of anecdotal reports endorse the benefits of rotor wing simulator SD training, with a small trial substantiating
performance improvement. Advancing technologies enable novel training applications. The mobile nature of flight students and concurrent anticollision technologies can make long-range assessment of SD training efficacy challenging. Costs of advanced technologies could limit the extent to which
the most advanced simulators can be employed across the rotor wing community.DISCUSSION: Evidence suggests the excellent training value of rotor wing simulators for SD training. Objective data from further research, particularly with regards to evolving technologies, may justify
further usage of advanced simulator platforms for SD training and research.Powell-Dunford N, Bushby A, Leland RA. Spatial disorientation training in the rotor wing flight simulator. Aerosp Med Hum Perform. 2016; 87(10):890–893.
The Physicochemical Optimization and Acceptability of a Cashew Nut-Based Beverage Varying in Mango Juice and Sugar: A Pilot Study
Authors: Rebouças Marina , Rodrigues Maria , De Freitas Silvia , Ferreira Bruno
Published: September 2016

The development of a lactose-free beverage comes as a new feeding alternative to a product with excellent nutritional and functional characteristics to individuals with food restrictions related to milk. Thus, this study aimed to develop a cashew nut beverage with added mango juice and prebiotic substances by means of evaluating its sensory characteristics and physicochemical optimization. A 22 central composite rotatable design with five repetitions at the central point was applied to evaluate the effect of sugar and juice contents on the analyzed parameters. Data were evaluated by means of the response surface methodology, analysis of variance, and the means comparison test. Formulations with greater combined concentrations of juice and sugar obtained satisfactory acceptance. The means comparison test showed that the formulation that allows for the beverage’s greatest acceptance must contain 40% mango juice and 8% sugar. Soluble solids content was influenced only by the addition of sugar, where the formulations that presented greater solids concentration were the ones which obtained greater sensory acceptance. The beverage’s acidity was influenced only by the juice content, which, besides making formulations significantly more acid, did not affect their acceptance.
Technical Considerations for the Generation of Adoptively Transferred T Cells in Cancer Immunotherapy
Authors: Visioni Anthony , Skitzki Joseph
Published: September 2016

A significant function of the immune system is the surveillance and elimination of aberrant cells that give rise to cancer. Even when tumors are well established and metastatic, immune-mediated spontaneous regressions have been documented. While there are have been various forms of immunotherapy, one of the most widely studied for almost 40 years is adoptive cellular immunotherapy, but its success has yet to be fully realized. Adoptive cell transfer (ACT) is a therapeutic modality that has intrigued physicians and researchers for its many theoretical benefits. Preclinical investigations and human trials have utilized natural killer (NK) cells, dendritic cells (DC), macrophages, T-cells or B-cells for ACT with the most intense research focused on T-cell ACT. T-cells are exquisitely specific to the target of its T-cell receptor (TCR), thus potentially reducing the amount of collateral damage and off-target effects from treatment. T-cells also possess a memory subset that may reduce the risk of recurrence of a cancer after the successful treatment of the primary disease. There are several options for the source of T-cells used in the generation of cells for ACT. Perhaps the most widely known source is T-cells generated from tumor-infiltrating lymphocytes (TILs). However, studies have also employed peripheral blood mononuclear cells (PBMCs), lymph nodes, and even induced pluripotent stem cells (IPSCs) as a source of T-cells. Several important technical considerations exist regarding benefits and limitations of each source of T-cells. Unique aspects of T-cells factor into their ability to be efficacious in ACT including the total number of cells available for ACT, the anti-tumor efficacy on a per cell basis, the repertoire of TCRs specific to tumor cells, and their ability to traffic to various organs that harbor tumor. Current research is attempting to unlock the full potential of these cells to effectively and safely treat cancer.
Erratum: Lazar-Karsten, P., et al. Generation and Characterization of Vascular Smooth Muscle Cell Lines Derived from a Patient with a Bicuspid Aortic Valve. Cells 2016, 5, 19.
Authors: Lazar-Karsten Pamela , Belge Gazanfer , Schult-Badusche Detlev , Focken Tim , Radtke Arlo , Yan Junfeng , Ranabhat Pramod , Mohamed Salah
Published: September 2016

The authors wish to make the following erratum to this paper [1].[...]
Rewiring of Developing Spinal Nociceptive Circuits by Neonatal Injury and Its Implications for Pediatric Chronic Pain
Authors: Baccei Mark
Published: September 2016

Significant evidence now suggests that neonatal tissue damage can evoke long-lasting changes in pain sensitivity, but the underlying cellular and molecular mechanisms remain unclear. This review highlights recent advances in our understanding of how injuries during a critical period of early life modulate the functional organization of synaptic networks in the superficial dorsal horn (SDH) of the spinal cord in a manner that favors the excessive amplification of ascending nociceptive signaling to the brain, which likely contributes to the generation and/or maintenance of pediatric chronic pain. These persistent alterations in synaptic function within the SDH may also contribute to the well-documented “priming” of developing pain pathways by neonatal tissue injury.
Experimental and Numerical Research Activity on a Packed Bed TES System
Authors: Cascetta Mario , Serra Fabio , Arena Simone , Casti Efisio , Cau Giorgio , Puddu Pierpaolo
Published: September 2016

This paper presents the results of experimental and numerical research activities on a packed bed sensible thermal energy storage (TES) system. The TES consists of a cylindrical steel tank filled with small alumina beads and crossed by air used as the heat transfer fluid. Experimental tests were carried out while varying some operating parameters such as the mass flow rate, the inlet–outlet temperature thresholds and the aspect ratio (length over diameter). Numerical simulations were carried out using a one-dimensional model, specifically developed in the Matlab-Simulink environment and a 2D axisymmetric model based on the ANSYS-Fluent platform. Both models are based on a two-equation transient approach to calculate fluid and solid phase temperatures. Thermodynamic properties were considered to be temperature-dependent and, in the Computational Fluid Dynamics (CFD) model, variable porosity of the bed in the radial direction, thermal losses and the effective conductivity of the alumina beads were also considered. The simulation results of both models were compared to the experimental ones, showing good agreement. The one-dimensional model has the advantage of predicting the axial temperature distribution with a very low computational cost, but it does not allow calculation of the correct energy stored when the temperature distribution is strongly influenced by the wall. To overcome this problem a 2D CFD model was used in this work.
Investigation of Energy and Environmental Potentials of a Renewable Trigeneration System in a Residential Application
Authors: Kang Eun-Chul , Lee Euy-Joon , Ghorab Mohamed , Yang Libing , Entchev Evgueniy , Lee Kwang-Seob , Lyu Nam-Jin
Published: September 2016

Micro polygeneration utilizing renewable energy is a suitable approach to reduce energy consumption and carbon emission by offering high-efficiency performance, offsetting the need for centrally-generated grid electricity and avoiding transmission/distribution losses associated with it. This paper investigates the energy and environmental potential of a renewable trigeneration system in a residential application under Incheon (Korea) and Ottawa (Canada) weather conditions. The trigeneration system consists of a ground-to-air heat exchanger (GAHX), photovoltaic thermal (PVT) panels and an air-to-water heat pump (AWHP). The study is performed by simulations in TRNSYS (Version 17.02) environment. The performance of the trigeneration system is compared to a reference conventional system that utilizes a boiler for space and domestic hot water heating and a chiller for space cooling. Simulation results showed substantial annual primary energy savings from the renewable trigeneration system in comparison to the reference system—45% for Incheon and 42% for Ottawa. The CO2eq emission reduction from the renewable trigeneration system is also significant, standing at 43% for Incheon and 82% for Ottawa. Furthermore, trigeneration systems’ capability to generate electricity and thermal energy at the point of use is considered as an attractive option for inclusion in the future smart energy network applications.
High-Resolution Wave Energy Assessment in Shallow Water Accounting for Tides
Authors: Silva Dina , Rusu Eugen , Guedes Soares Carlos
Published: September 2016

The wave energy in a shallow water location is evaluated considering the influence of the local tide and wind on the wave propagation. The target is the coastal area just north of the Portuguese city of Peniche, where a wave energy converter operates on the sea bottom. A wave modelling system based on SWAN has been implemented and focused on this coastal environment in a multilevel computational scheme. The first three SWAN computational belonging to this wave prediction system were defined using the spherical coordinates. In the highest resolution computational domain, Cartesian coordinates have been considered, with a resolution of 25 m in both directions. An in-depth analysis of the main characteristics of the environmental matrix has been performed. This is based on the results of eight-year model system simulations (2005–2012). New simulations have been carried out in the last two computational domains with the most relevant wave and wind patterns, considering also the tide effect. The results show that the tide level, together with the wind intensity and direction, may influence to a significant degree the wave characteristics. This especially concerns the wave power in the location where the wave converter operates.
Re-Affecting the Stage: Affective Resonance as the Function of the Audience
Authors: Pais Ana
Published: September 2016

This article uses an affect theory framework to show how the audience has the power to intensify the circulation of affect in the theatrical encounter, and to impact on the unique felt quality of the performance. Assessment is made of the vital function of affect to performance through the images, sensations and expressions that performers use to describe audience engagement. Intermittently, from 2010 to 2012, the author embarked on practice-led research to find out how performers describe the experience of being on stage with regard to their engagement with an audience. Conversations were recorded with more than 50 performers (mainly actors and dancers) from the USA and Brazil, as well as Portugal and other European countries.
Molecular Pathogenesis of NASH
Authors: Caligiuri Alessandra , Gentilini Alessandra , Marra Fabio
Published: September 2016

Nonalcoholic steatohepatitis (NASH) is the main cause of chronic liver disease in the Western world and a major health problem, owing to its close association with obesity, diabetes, and the metabolic syndrome. NASH progression results from numerous events originating within the liver, as well as from signals derived from the adipose tissue and the gastrointestinal tract. In a fraction of NASH patients, disease may progress, eventually leading to advanced fibrosis, cirrhosis and hepatocellular carcinoma. Understanding the mechanisms leading to NASH and its evolution to cirrhosis is critical to identifying effective approaches for the treatment of this condition. In this review, we focus on some of the most recent data reported on the pathogenesis of NASH and its fibrogenic progression, highlighting potential targets for treatment or identification of biomarkers of disease progression.
Candida antarctica Lipase B Immobilized onto Chitin Conjugated with POSS® Compounds: Useful Tool for Rapeseed Oil Conversion
Authors: Zdarta Jakub , Wysokowski Marcin , Norman Małgorzata , Kołodziejczak-Radzimska Agnieszka , Moszyński Dariusz , Maciejewski Hieronim , Ehrlich Hermann , Jesionowski Teofil
Published: September 2016

A new method is proposed for the production of a novel chitin-polyhedral oligomeric silsesquioxanes (POSS) enzyme support. Analysis by such techniques as X-ray photoelectron spectroscopy (XPS) and Raman spectroscopy confirmed the effective functionalization of the chitin surface. The resulting hybrid carriers were used in the process of immobilization of the lipase type b from Candida antarctica (CALB). Fourier transform infrared spectroscopy (FTIR) confirmed the effective immobilization of the enzyme. The tests of the catalytic activity showed that the resulting support-biocatalyst systems remain hydrolytically active (retention of the hydrolytic activity up to 87% for the chitin + Methacryl POSS® cage mixture (MPOSS) + CALB after 24 h of the immobilization), as well as represents good thermal and operational stability, and retain over 80% of its activity in a wide range of temperatures (30–60 °C) and pH (6–9). Chitin-POSS-lipase systems were used in the transesterification processes of rapeseed oil at various reaction conditions. Produced systems allowed the total conversion of the oil to fatty acid methyl esters (FAME) and glycerol after 24 h of the process at pH 10 and a temperature 40 °C, while the Methacryl POSS® cage mixture (MPOSS) was used as a chitin-modifying agent.
Salinity-Induced Variation in Biochemical Markers Provides Insight into the Mechanisms of Salt Tolerance in Common (Phaseolus vulgaris) and Runner (P. coccineus) Beans
Authors: Al Hassan Mohamad , Morosan Mihaela , López-Gresa María , Prohens Jaime , Vicente Oscar , Boscaiu Monica
Published: September 2016

The evaluation of biochemical markers is important for the understanding of the mechanisms of tolerance to salinity of Phaseolus beans. We have evaluated several growth parameters in young plants of three Phaseolus vulgaris cultivars subjected to four salinity levels (0, 50, 100, and 150 mM NaCl); one cultivar of P. coccineus, a closely related species reported as more salt tolerant than common bean, was included as external reference. Biochemical parameters evaluated in leaves of young plants included the concentrations of ions (Na+, K+, and Cl−), osmolytes (proline, glycine betaine, and total soluble sugars), and individual soluble carbohydrates. Considerable differences were found among cultivars, salinity levels, and in their interaction for most traits. In general, the linear component of the salinity factor for the growth parameters and biochemical markers was the most important. Large differences in the salinity response were found, with P. vulgaris cultivars “The Prince” and “Maxidor” being, respectively, the most susceptible and tolerant ones. Our results support that salt stress tolerance in beans is mostly based on restriction of Na+ (and, to a lesser extent, also of Cl−) transport to shoots, and on the accumulation of myo-inositol for osmotic adjustment. These responses to stress during vegetative growth appear to be more efficient in the tolerant P. vulgaris cultivar “Maxidor”. Proline accumulation is a reliable marker of the level of salt stress affecting Phaseolus plants, but does not seem to be directly related to stress tolerance mechanisms. These results provide useful information on the responses to salinity of Phaseolus.
Elastic Modulus of the Alkali-Silica Reaction Rim in a Simplified Calcium-Alkali-Silicate System Determined by Nano-Indentation
Authors: Zheng Kunpeng , Lukovic Mladena , De Schutter Geert , Ye Guang , Taerwe Luc
Published: September 2016

This work aims at providing a better understanding of the mechanical properties of the reaction rim in the alkali-silica reaction. The elastic modulus of the calcium alkali silicate constituting the reaction rim, which is formed at the interface between alkali silicate and Ca(OH)2 in a chemically-idealized system of the alkali-silica reaction, was studied using nano-indentation. In addition, the corresponding calcium to silica mole ratio of the calcium alkali silicate was investigated. The results show that the elastic modulus of the calcium alkali silicate formed at the interface increased with the increase of the calcium to silica mole ratio and vice versa. Furthermore, the more calcium that was available for interaction with alkali silicate to form calcium alkali silicate, the higher the calcium to silica mole ratio and, consequently, the higher the elastic modulus of the formed calcium alkali silicate. This work provides illustrative evidence from a mechanical point of view on how the occurrence of cracks due to the alkali-silica reaction (ASR) is linked to the formation of the reaction rim. It has to be highlighted, however, that the simplified calcium-alkali-silicate system in this study is far from the real condition in concrete.
Deformability-Based Electrokinetic Particle Separation
Authors: Zhou Teng , Yeh Li-Hsien , Li Feng-Chen , Mauroy Benjamin , Joo Sang
Published: September 2016

Deformability is an effective property that can be used in the separation of colloidal particles and cells. In this study, a microfluidic device is proposed and tested numerically for the sorting of deformable particles of various degrees. The separation process is numerically investigated by a direct numerical simulation of the fluid–particle–electric field interactions with an arbitrary Lagrangian–Eulerian finite-element method. The separation performance is investigated with the shear modulus of particles, the strength of the applied electric field, and the design of the contracted microfluidic devices as the main parameters. The results show that the particles with different shear moduli take different shapes and trajectories when passing through a microchannel contraction, enabling the separation of particles based on their difference in deformability.
Therapeutic Effects of Phytochemicals and Medicinal Herbs on Chemotherapy-Induced Peripheral Neuropathy
Authors: Lee Gihyun , Kim Sun
Published: September 2016

Chemotherapy-induced peripheral neuropathy (CIPN) is a frequent adverse effect of neurotoxic anticancer medicines. It leads to autonomic and somatic system dysfunction and decreases the patient’s quality of life. This side effect eventually causes chemotherapy non-compliance. Patients are prompted to seek alternative treatment options since there is no conventional remedy for CIPN. A range of medicinal herbs have multifarious effects, and they have shown some evidence of efficacy in various neurological and immunological diseases. While CIPN has multiple mechanisms of neurotoxicity, these phytomedicines might offer neuronal protection or regeneration with the multiple targets in CIPN. Thus far, researchers have investigated the therapeutic benefits of several herbs, herbal formulas, and phytochemicals in preventing the onset and progress of CIPN in animals and humans. Here, we summarize current knowledge regarding the role of phytochemicals, herb extracts, and herbal formulas in alleviating CIPN.
The Suppressive Effects of Cinnamomi Cortex and Its Phytocompound Coumarin on Oxaliplatin-Induced Neuropathic Cold Allodynia in Rats
Authors: Kim Changmin , Lee Ji , Kim Woojin , Li Dongxing , Kim Yangseok , Lee Kyungjin , Kim Sun
Published: September 2016

Oxaliplatin, a chemotherapy drug, induces acute peripheral neuropathy characterized by cold allodynia, spinal glial activation and increased levels of pro-inflammatory cytokines. Herein, we determined whether Cinnamomi Cortex (C. Cortex), a widely used medicinal herb in East Asia for cold-related diseases, could attenuate oxaliplatin-induced cold allodynia in rats and the mechanisms involved. A single oxaliplatin injection (6 mg/kg, i.p.) induced significant cold allodynia signs based on tail immersion tests using cold water (4 °C). Daily oral administration of water extract of C. Cortex (WECC) (100, 200, and 400 mg/kg) for five consecutive days following an oxaliplatin injection dose-dependently alleviated cold allodynia with only a slight difference in efficacies between the middle dose at 200 mg/kg and the highest dose at 400 mg/kg. WECC at 200 mg/kg significantly suppressed the activation of astrocytes and microglia and decreased the expression levels of IL-1β and TNF in the spinal cord after injection with oxaliplatin. Furthermore, oral administration of coumarin (10 mg/kg), a major phytocompound of C. Cortex, markedly reduced cold allodynia. These results indicate that C. Cortex has a potent anti-allodynic effect in oxaliplatin-injected rats through inhibiting spinal glial cells and pro-inflammatory cytokines. We also suggest that coumarin might play a role in the anti-allodynic effect of C. Cortex.
Fructose Beverage Consumption Induces a Metabolic Syndrome Phenotype in the Rat: A Systematic Review and Meta-Analysis
Authors: Toop Carla , Gentili Sheridan
Published: September 2016

A high intake of refined carbohydrates, particularly the monosaccharide fructose, has been attributed to the growing epidemics of obesity and type-2 diabetes. Animal studies have helped elucidate the metabolic effects of dietary fructose, however, variations in study design make it difficult to draw conclusions. The aim of this study was to review the effects of fructose beverage consumption on body weight, systolic blood pressure and blood glucose, insulin and triglyceride concentrations in validated rat models. We searched Ovid Embase Classic + EmbaseMedline and Ovid Medline databases and included studies that used adolescent/adult male rats, with fructose beverage consumption for >3 weeks. Data from 26 studies were pooled by an inverse variance weighting method using random effects models, expressed as standardized mean differences (SMD) with 95% confidence intervals (CI). Overall, 10%–21% w/v fructose beverage consumption was associated with increased rodent body weight (SMD, 0.62 (95% CI: 0.18, 1.06)), systolic blood pressure (SMD, 2.94 (95% CI: 2.10, 3.77)) and blood glucose (SMD, 0.77 (95% CI: 0.36, 1.19)), insulin (SMD, 2.32 (95% CI: 1.57, 3.07)) and triglyceride (SMD, 1.87 (95% CI: 1.39, 2.34)) concentrations. Therefore, the consumption of a low concentration fructose beverage is sufficient to cause early signs of the metabolic syndrome in adult rats.
Nanoindentation Investigation of Temperature Effects on the Mechanical Properties of Nafion® 117
Authors: Xia Re , Zhou Hongjian , Wu Runni , Wu Wen-Ping
Published: September 2016

Operating temperature can be a limiting factor in reliable applications of Proton Exchange Membrane (PEM) fuel cells. Nanoindentation tests were performed on perfluorosulfonic acid (PFSA) membranes (Nafion® 117) in order to study the influence of the temperature condition on their mechanical properties. The hardness and reduced modulus of Nafion® 117 were measured within a certain temperature range, from 10 to 70 °C. The results indicate that both hardness and elastic modulus show non-monotonic transition with the increase of the test temperature, with reaching peak values of 0.143 and 0.833 GPa at 45 °C. It also found that the membranes have a shape memory effect and a temperature dependent shape recovery ratio.
Local Knowledge and Professional Background Have a Minimal Impact on Volunteer Citizen Science Performance in a Land-Cover Classification Task
Authors: Salk Carl , Sturn Tobias , See Linda , Fritz Steffen
Published: September 2016

The idea that closer things are more related than distant things, known as ‘Tobler’s first law of geography’, is fundamental to understanding many spatial processes. If this concept applies to volunteered geographic information (VGI), it could help to efficiently allocate tasks in citizen science campaigns and help to improve the overall quality of collected data. In this paper, we use classifications of satellite imagery by volunteers from around the world to test whether local familiarity with landscapes helps their performance. Our results show that volunteers identify cropland slightly better within their home country, and do slightly worse as a function of linear distance between their home and the location represented in an image. Volunteers with a professional background in remote sensing or land cover did no better than the general population at this task, but they did not show the decline with distance that was seen among other participants. Even in a landscape where pasture is easily confused for cropland, regional residents demonstrated no advantage. Where we did find evidence for local knowledge aiding classification performance, the realized impact of this effect was tiny. Rather, the inherent difficulty of a task is a much more important predictor of volunteer performance. These findings suggest that, at least for simple tasks, the geographical origin of VGI volunteers has little impact on their ability to complete image classifications.
Dynamics of Fractional Vegetation Coverage and Its Relationship with Climate and Human Activities in Inner Mongolia, China
Authors: Tong Siqin , Zhang Jiquan , Ha Si , Lai Quan , Ma Qiyun
Published: September 2016

Long-term remote sensing normalized difference vegetation index (NDVI) datasets have been widely used in monitoring vegetation changes. In this study, the NASA Global Inventory Modeling and Mapping Studies (GIMMS) NDVI3g dataset was used as the data source, and the dimidiate pixel model, intensity analysis, and residual analysis were used to analyze the changes of vegetation coverage in Inner Mongolia—from 1982 to 2010—and their relationships with climate and human activities. This study also explored vegetation changes in Inner Mongolia with respect to natural factors and human activities. The results showed that the estimated vegetation coverage exhibited a high correlation (0.836) with the actual measured values. The increased vegetation coverage area (49.2% of the total area) was larger than the decreased area (43.3%) from the 1980s to the 1990s, whereas the decreased area (57.1%) was larger than the increased area (35.6%) from the 1990s to the early 21st century. This finding indicates that vegetation growth in the 1990s was better than that in the other two decades. Intensity analysis revealed that changes in the average annual rate from the 1990s to the early 21st century were relatively faster than those in the 1980s–1990s. During the 1980s–1990s, the gain of high vegetation coverage areas was active, and the loss was dormant; in contrast, the gain and loss of low vegetation coverage areas were both dormant. In the 1990s to the early 21st century, the gains of high and low vegetation coverage areas were both dormant, whereas the losses were active. During the study period, areas of low vegetation coverage were converted into ones with higher coverage, and areas of high vegetation coverage were converted into ones with lower coverage. The vegetation coverage exhibited a good correlation (R2 = 0.60) with precipitation, and the positively correlated area was larger than the negatively correlated area. Human activities not only promote the vegetation coverage, but also have a destructive effect on vegetation, and the promotion effect during 1982 to 2000 was larger than from 2001 to 2010, while, the destructive effect was larger from 2000 to 2010.
Combating QR-Code-Based Compromised Accounts in Mobile Social Networks
Authors: Guo Dong , Cao Jian , Wang Xiaoqi , Fu Qiang , Li Qiang
Published: September 2016

Cyber Physical Social Sensing makes mobile social networks (MSNs) popular with users. However, such attacks are rampant as malicious URLs are spread covertly through quick response (QR) codes to control compromised accounts in MSNs to propagate malicious messages. Currently, there are generally two types of methods to identify compromised accounts in MSNs: one type is to analyze the potential threats on wireless access points and the potential threats on handheld devices’ operation systems so as to stop compromised accounts from spreading malicious messages; the other type is to apply the method of detecting compromised accounts in online social networks to MSNs. The above types of methods above focus neither on the problems of MSNs themselves nor on the interaction of sensors’ messages, which leads to the restrictiveness of platforms and the simplification of methods. In order to stop the spreading of compromised accounts in MSNs effectively, the attacks have to be traced to their sources first. Through sensors, users exchange information in MSNs and acquire information by scanning QR codes. Therefore, analyzing the traces of sensor-related information helps to identify the compromised accounts in MSNs. This paper analyzes the diversity of information sending modes of compromised accounts and normal accounts, analyzes the regularity of GPS (Global Positioning System)-based location information, and introduces the concepts of entropy and conditional entropy so as to construct an entropy-based model based on machine learning strategies. To achieve the goal, about 500,000 accounts of Sina Weibo and about 100 million corresponding messages are collected. Through the validation, the accuracy rate of the model is proved to be as high as 87.6%, and the false positive rate is only 3.7%. Meanwhile, the comparative experiments of the feature sets prove that sensor-based location information can be applied to detect the compromised accounts in MSNs.
Design of Highly Selective Gas Sensors via Physicochemical Modification of Oxide Nanowires: Overview
Authors: Woo Hyung-Sik , Na Chan , Lee Jong-Heun
Published: September 2016

Strategies for the enhancement of gas sensing properties, and specifically the improvement of gas selectivity of metal oxide semiconductor nanowire (NW) networks grown by chemical vapor deposition and thermal evaporation, are reviewed. Highly crystalline NWs grown by vapor-phase routes have various advantages, and thus have been applied in the field of gas sensors over the years. In particular, n-type NWs such as SnO2, ZnO, and In2O3 are widely studied because of their simple synthetic preparation and high gas response. However, due to their usually high responses to C2H5OH and NO2, the selective detection of other harmful and toxic gases using oxide NWs remains a challenging issue. Various strategies—such as doping/loading of noble metals, decorating/doping of catalytic metal oxides, and the formation of core–shell structures—have been explored to enhance gas selectivity and sensitivity, and are discussed herein. Additional methods such as the transformation of n-type into p-type NWs and the formation of catalyst-doped hierarchical structures by branch growth have also proven to be promising for the enhancement of gas selectivity. Accordingly, the physicochemical modification of oxide NWs via various methods provides new strategies to achieve the selective detection of a specific gas, and after further investigations, this approach could pave a new way in the field of NW-based semiconductor-type gas sensors.
Hesitant Trapezoidal Fuzzy QUALIFLEX Method and Its Application in the Evaluation of Green Supply Chain Initiatives
Authors: Zhang Xiaolu , Xu Zeshui , Liu Manfeng
Published: September 2016

This paper explores how to handle multiple criteria decision-making (MCDM) problems in which the criteria values of alternatives take the form of comparative linguistic expressions. Firstly, the new concept of hesitant trapezoidal fuzzy numbers (HTrFNs) is provided to model the semantics of the comparative linguistic expressions. Then, the operational laws and the distance measures of HTrFNs are presented. Afterwards, a useful outranking method, the hesitant trapezoidal fuzzy QUALIFLEX method, is developed to handle the MCDM problems with hierarchical structure in the environment of HTrFN. At length, the proposed method is applied to evaluating green supply chain initiatives in order to achieve sustainable economic and environmental performance, and a case study concerned with a fashion retail chain is presented to demonstrate its feasibility and applicability, also, a comparative analysis with other relevant approaches is conducted to validate the effectiveness of the proposed method.
A Social-Ecological Framework for Urban Stewardship Network Research to Promote Sustainable and Resilient Cities
Authors: Romolini Michele , Bixler R. , Grove J.
Published: September 2016

To realize more sustainable and resilient urban social-ecological systems, there is great need for active engagement from diverse public agencies, non-profit organizations, businesses, natural resource managers, scientists, and other actors. Cities present unique challenges and opportunities for sustainability and resilience, as issues and organizations are frequently intertwined in networks of relations. Understanding and leveraging the range of knowledge types, motivations, skills, and goals of diverse participants and their networks is fundamental to sustainable and resilient cities. As efforts to examine and understand urban stewardship networks continue to emerge, it is increasingly clear that there are no structured or systematic frameworks to guide the integration of social and ecological phenomena. Such a framework could facilitate planning new urban stewardship network research, and provide a basis for comparisons among cities and their urban stewardship networks. In this paper, we develop and present a social-ecological framework for examining and understanding urban stewardship networks. To illustrate this framework and provide examples of its prospective and evaluative utility, we use examples from the U.S. Forest Service’s Stewardship Mapping (STEW-MAP) network in the United States from Baltimore, MD, USA, New York City, NY, USA, San Juan, Puerto Rico, USA, and Seattle, WA, USA.
The Host Cell Receptors for Measles Virus and Their Interaction with the Viral Hemagglutinin (H) Protein
Authors: Lin Liang-Tzung , Richardson Christopher
Published: September 2016

The hemagglutinin (H) protein of measles virus (MeV) interacts with a cellular receptor which constitutes the initial stage of infection. Binding of H to this host cell receptor subsequently triggers the F protein to activate fusion between virus and host plasma membranes. The search for MeV receptors began with vaccine/laboratory virus strains and evolved to more relevant receptors used by wild-type MeV. Vaccine or laboratory strains of measles virus have been adapted to grow in common cell lines such as Vero and HeLa cells, and were found to use membrane cofactor protein (CD46) as a receptor. CD46 is a regulator that normally prevents cells from complement-mediated self-destruction, and is found on the surface of all human cells, with the exception of erythrocytes. Mutations in the H protein, which occur during adaptation and allow the virus to use CD46 as a receptor, have been identified. Wild-type isolates of measles virus cannot use the CD46 receptor. However, both vaccine/laboratory and wild-type strains can use an immune cell receptor called signaling lymphocyte activation molecule family member 1 (SLAMF1; also called CD150) and a recently discovered epithelial receptor known as Nectin-4. SLAMF1 is found on activated B, T, dendritic, and monocyte cells, and is the initial target for infections by measles virus. Nectin-4 is an adherens junction protein found at the basal surfaces of many polarized epithelial cells, including those of the airways. It is also over-expressed on the apical and basal surfaces of many adenocarcinomas, and is a cancer marker for metastasis and tumor survival. Nectin-4 is a secondary exit receptor which allows measles virus to replicate and amplify in the airways, where the virus is expelled from the body in aerosol droplets. The amino acid residues of H protein that are involved in binding to each of the receptors have been identified through X-ray crystallography and site-specific mutagenesis. Recombinant measles “blind” to each of these receptors have been constructed, allowing the virus to selectively infect receptor specific cell lines. Finally, the observations that SLAMF1 is found on lymphomas and that Nectin-4 is expressed on the cell surfaces of many adenocarcinomas highlight the potential of measles virus for oncolytic therapy. Although CD46 is also upregulated on many tumors, it is less useful as a target for cancer therapy, since normal human cells express this protein on their surfaces.
Orchestrating the Selection and Packaging of Genomic RNA by Retroviruses: An Ensemble of Viral and Host Factors
Authors: Kaddis Maldonado Rebecca , Parent Leslie
Published: September 2016

Infectious retrovirus particles contain two copies of unspliced viral RNA that serve as the viral genome. Unspliced retroviral RNA is transcribed in the nucleus by the host RNA polymerase II and has three potential fates: (1) it can be spliced into subgenomic messenger RNAs (mRNAs) for the translation of viral proteins; or it can remain unspliced to serve as either (2) the mRNA for the translation of Gag and Gag–Pol; or (3) the genomic RNA (gRNA) that is packaged into virions. The Gag structural protein recognizes and binds the unspliced viral RNA to select it as a genome, which is selected in preference to spliced viral RNAs and cellular RNAs. In this review, we summarize the current state of understanding about how retroviral packaging is orchestrated within the cell and explore potential new mechanisms based on recent discoveries in the field. We discuss the cis-acting elements in the unspliced viral RNA and the properties of the Gag protein that are required for their interaction. In addition, we discuss the role of host factors in influencing the fate of the newly transcribed viral RNA, current models for how retroviruses distinguish unspliced viral mRNA from viral genomic RNA, and the possible subcellular sites of genomic RNA dimerization and selection by Gag. Although this review centers primarily on the wealth of data available for the alpharetrovirus Rous sarcoma virus, in which a discrete RNA packaging sequence has been identified, we have also summarized the cis- and trans-acting factors as well as the mechanisms governing gRNA packaging of other retroviruses for comparison.
X‐rays and virtual taphonomy resolve the first Cissus (Vitaceae) macrofossils from Africa as early‐diverging members of the genus
Authors: Adams Neil F. , Collinson Margaret E. , Smith Selena Y. , Bamford Marion K. , Forest Félix , Malakasi Panagiota , Marone Federica , Dan Sykes
Published: September 2016

PREMISE OF THE STUDY:

Fossilized seeds similar to Cissus (Vitaceae) have been recognized from the Miocene of Kenya, though some were previously assigned to the Menispermaceae. We undertook a comparative survey of extant African Cissus seeds to identify the fossils and consider their implications for the evolution and biogeography of Cissus and for African early Miocene paleoenvironments.

METHODS:

Micro‐computed tomography (µCT) and synchrotron‐based X‐ray tomographic microscopy (SRXTM) were used to study seed morphology and anatomy. Virtual taphonomy, using SRXTM data sets, produced digital fossils to elucidate seed taphonomy. Phylogenetic relationships within Cissus were reconstructed using existing and newly produced DNA sequences for African species. Paleobiology and paleoecology were inferred from African nearest living relatives.

KEY RESULTS:

The fossils were assigned to four new Cissus species, related to four modern clades. The fossil plants were interpreted as climbers inhabiting a mosaic of riverine woodland and forest to more open habitats. Virtual taphonomy explained how complex mineral infill processes concealed key seed features, causing the previous taxonomic misidentification. Newly sampled African species, with seeds most similar to the fossils, belong to four clades within core Cissus, two of which are early diverging.

CONCLUSIONS:

Virtual taphonomy, combined with X‐ray imaging, has enabled recognition of the first fossil Cissus and Vitaceae from Africa. Early‐divergent members of the core Cissus clade were present in Africa by at least the early Miocene, with an African origin suggested for the Cissus sciaphila clade. The fossils provide supporting evidence for mosaic paleoenvironments inhabited by early Miocene hominoids.
A BROADBAND X-RAY SPECTRAL STUDY OF THE INTERMEDIATE-MASS BLACK HOLE CANDIDATE M82 X-1 WITH NuSTAR, CHANDRA, AND SWIFT
Authors: Brightman Murray , Harrison Fiona A. , Barret Didier , Davis Shane W. , Fürst Felix , Madsen Kristin K. , Middleton Matthew , Miller Jon M. , Stern Daniel , Tao Lian , Walton Dominic J.
Published: September 2016

M82 X-1 is one of the brightest ultraluminous X-ray sources (ULXs) known, which, assuming Eddington-limited accretion and other considerations, makes it one of the best intermediate-mass black-hole (IMBH) candidates. However, the ULX may still be explained by super-Eddington accretion onto a stellar remnant black hole. We present simultaneous NuSTAR, Chandra, and Swift/XRT observations during the peak of a flaring episode with the aim of modeling the emission of M82 X-1 and yielding insights into its nature. We find that thin accretion disk models all require accretion rates at or above the Eddington limit in order to reproduce the spectral shape, given a range of black-hole masses and spins. Since at these high Eddington ratios the thin-disk model breaks down due to radial advection in the disk, we discard the results of the thin-disk models as unphysical. We find that the temperature profile as a function of disk radius (

) is significantly flatter (

) than expected for a standard thin disk (p = 0.75). A flatter profile is instead characteristic of a slim disk, which is highly suggestive of super-Eddington accretion. Furthermore, radiation hydrodynamical simulations of super-Eddington accretion have shown that the predicted spectra of these systems are very similar to what we observe for M82 X-1. We therefore conclude that M82 X-1 is a super-Eddington accretor. Our mass estimates inferred from the inner disk radius imply a stellar remnant black hole (

=

M
⊙) when assuming zero spin and face-on inclination, or an IMBH for maximal spin and a highly inclined disk.