bluuebunny/crossref_metadata_2025 huggingface dataset:
THE ROLE OF THE INSTUMENTAL EXAMINATIONS IN DIAGNOSTICS AND STAGING OF LOCALY DISTRIBUTED STOMACH CANCER
Authors: Lazirskiy V. A. , Farzullayev N. N.
Published: January 2022

Objective. Improvement of algorithm of diagnostics of patients with complicated stomach cancer.

Materials and methods. It was shown the analysis of results of surgical treatment of 418 patients with complicated stomach cancer, which got the hospital treatment at GI “V.T. Zaycev Institute of General and Urgent Surgery of NAMS of Ukraine “ from 2010 till 2019, aged 29 till 76.

Results. Patiens were examinated with using of combination of instrumental methods. Goal is total detal examination of pathologic process. SCT has precission of 95-97 % at detecting of cancer, definition of stage – 77-80 %. Endoscopy allows to define the location, spreading of process, to find a pathologic process at starting and precancer stages. There no any ideal oncomarker. Diagnostic precission of CA 72-4 is 28-80 % (40-46 % on the average). According to international guides [7], all patients were performed the diagnostic laparoscopy with researching of washout liquids of abdomen in uncertain cases.

Conclusion. Only complex examination of patients with stomach cancer with using combination of SCT of abdomen, FEGDS with biopsy, laparoscopy can provide total volum of examination, staging and surgical aid.
SELECTION OF SURGICAL TACTICS FOR TREATMENT OF NON-APHENIC VARICOSIS ON THE RESULTS OF US-DIAGNOSTICS OF THE VENES OF THE LOWER LIMBS
Authors: Novikova A. , Babinkina I. B. , Babinkina G. P. , Provar L. V. , Golovina О. A.
Published: January 2022

Purpose of research. Determination of variants of the anatomical structure of non-saaphenic veins and pathological anastomoses in varicose enlargement of atypical venous basins with ultrasound Doppler of the veins of the lower extremities, including as sources of pathological venous reflux, as well as the importance of insolvent veins — perforants and non-saaphenic veins — in the formation of venous insufficiency to clarify the treatment protocol.

Materials and methods. The venous system was studied in 2348 pa tients, including both patients with various pathologies of the venous system, including those with varicose veins, and those in whom the pathology of the veins was not detected by Doppler ultrasound.

Research results and discussion. Surgical treatment for non-safenic varicose veins includes phlebectomy, sclerotherapy and Muller-Vara di minifblektomy, depending on the diameter of the affected nonsafenic vein.

Conclusions. The specialists’ understanding of the variants of nonsafenic varicose veins, as well as adherence to the full research protocol for ultrasound Doppler ultrasound of the veins, allows us to provide detailed information in order to determine the most effective treatment tactics and prevention of relapses and complications of the disease.
EXPERIMENTAL STUDY OF CLINICAL INDICATORS OF INTRATISSUE PRESSURE IN DEEP CIRCULAR BURNS AND ITS DYNAMICS DEPENDING ON THE NATURE AND VOLUME OF SURGERY
Authors: Kravtsov O. V. , Kurbanov T. A. , Kozin Yu. I.
Published: January 2022

The purpose of research. To improve in the experiment the optimal variants of surgical tactics to eliminate the phenomena of compartment syndrome in circular deep burns on the basis of studying the dynamics of intratissue pressure.

Materials and methods. An experiment to study the effectiveness of treatment of deep circular burns of III degree, accompanied by compartment-syndrome with objectification of intra-tissue pressure was performed on 18 male WAG rats weighing 190.0-200.0 g, which were divided into three groups depending from the nature and scope of surgery.

Research results and their discussion. Based on the assessment of the dependence of the level of intratissue pressure in the tissues on the timing of modeling of deep circular burns in the experiment and tactics and volume of surgical treatment, a clear dependence of indicators in all groups of experimental animals. The primary necrectomy performed in the III main group due to the radical surgical intervention allowed to completely normalize the intratissue pressure within 24 hours.

Conclusions. 1. Clinical indicators of intratissue pressure at deep circular burns depending on time of modeling of a thermal trauma and character and volume of surgical intervention are defined in experiment. 2. It is established that primary necrectomy due to radical excision of necrotized tissues and rapid decompression contributes to the nor malization of intratissue pressure.
SURGICAL TREATMENT OF PATIENTS WITH EXTRAORGANIC TUMORS OF THE PELVIC LOCALIZATION WITH INVASION OF THE ILIAC VESSELS
Authors: Kryvorotko I. V. , Chykin A. V. , Tymchenko M. Ye. , Beresnyev S. O. , Alexandrov T. Z.
Published: January 2022

The aim of our study was to determine the indications for expanding the scope of operations in patients with pelvic extraorgan local formations.

Materials and methods. The results of surgical treatment of 7 patients with nonorgan tumors of the pelvic localization, who underwent resection on the main vessels in connection with their involvement in the tumor process, are presented.

Results and discussion. A total of 7 interventions were performed on the iliac arteries — 2 resections with an end-to-end anastomosis and 5 prostheses (one case — the aorta resection with reconstruction with a bifurcation prosthesis).

Patients with pelvic extraorgan tumors are a special cohort of patients, due to the presence of several organs in a narrow space, which inevitably causes them to fit snugly to the tumor. Locally advanced tumor process in extraorganic tumors involving the main vessels of the pelvis and adjacent organs is not a reason to refuse surgery, and despite the complications, repeated recurrences and previous operations, are well tolerated by patients. This is especially important due to the lack of a real alternative to surgical treatment of this group of patients.

Conclusions. Surgical intervention in the treatment of pelvic inorganic tumors involving the main vessels is the only radical method of treatment. Invasion of the main arterial and venous vessels is not a contraindication to surgery in patients with pelvic tumors. Combined angioplastic interventions allow to achieve a long without recurrent period even after cytoreductive operations.
FEATURES OF SURGICAL TREATMENT OF GALLSTONE DISEASE AND PREVENTION OF ITS COMPLICATIONS
Authors: Kryzhevskii V. V. , Bilyayeva O. O. , Pavlovych Yu. V.
Published: January 2022

The aim. To analyze the results of surgical treatment of gallstone disease (GD), methods of prevention of complications.

Materials and methods. To analyze the results of surgical treatment of gallstone disease (GD), methods of preventing complications.

Results and discussion. The data of 204 patients with GD who underwent laparoscopic cholecystectomy (LC) at the Kiev City Hospital No. 6 and the Medical Center “Universal Clinic Oberig” for 2018 were analyzed.

Conclusions. The only radical method of treatment of CD is LC. To reduce the complications of LC, it is necessary to conduct the correct selection of patients and apply bail-out strategies to overcome complex LHE.
DETERMINATION OF PAIN IN PATIENTS WITH ACUTE CALCULOUS CHOLECYSTITIS IN PATIENTS WITH CHRONIC HEPATITIS
Authors: Kolotvin A. O. , Kashtalyan M. A. , Kolotvina L. I. , Kvasnevsky O. A. , Kvasnevsky E. A. , Illina-Stognienko V. Yu.
Published: January 2022

The aim. To establish the diagnostic value of the scale for assessing the severity of pain by determining the intensity of pain in patients with acute calculous cholecystitis in patients with chronic viral hepatitis.

Materials and methods of research. The study was conducted in the period from 2016 to 2021 in the Department of Emergency Surgery of the Military Medical Clinical Center. In the first stage, the diagnostic scheme included only surveys to identify potential risk factors for infection and anamnestic data on the presence of HCV diagnosed in the past. In the second stage, rapid tests for antigens and antibodies to HCV were introduced into the diagnostic scheme along with the survey.

Research results. Patients respond differently to pain, and the sen sation of pain is individual and subjective.

Conclusions. Quantitative assessment and registration of the inten sity of pain using a visual-analog scale can supplement the comprehensive information about the general condition of the patient, which is necessary to select the optimal treatment in emergency surgery.
FEATURES OF THE DYNAMIC OF ACUTE C-REACTIVE PROTEIN AND INDICATORS OF THE BODY’S IMMUNE SYSTEM AND THEIR RELATIONSHIP WITH THE CLINICAL PICTURE IN ELDERLY PATIENTS WITH ULCERATIVE GASTROINTESTINAL BLEEDING
Authors: Chukhriienko A. V. , Trofimov M. V.
Published: January 2022

The aim. Improve the effectiveness of treatment of elderly patients with ulcerative gastrointestinal bleeding by studying the dynamics of the level of C-reactive protein (CRP) and immune system parameters, their relationship with the clinical picture.

Materials and methods. 35 elderly patients in the period from 2019 to 2021 (according to the WHO classification — 61-90 years) with ulcerative gastrointestinal bleeding complicated by cardiovascular pathology. The gender distribution is as follows: men — 19 (54%), women — 16 (46%). The average age of the patients was 76.3 years. This category of patients was divided according to the methods of treatment of concomitant cardiovascular pathology: group A — patients who received therapy according to the standard scheme (n = 20), B — double (n = 15). As a control category of patients (n = 50) was selected. There are relatively healthy (donors), who were similar to the study group in terms of age, gender, and the method for determining indicators.

Results. The state of local endoscopic hemostasis in group “A” was investigated: Forrest II was detected in 14 (70%) patients, Forrest III — in 6 (30%) patients; in group “B”: Forrest I — in 7 (47%) patients, Forrest II — in 8 (53%) patients. These results indicate that using of dual therapy leads to a change in the rheological properties of blood, which, in turn, leads to a decrease in the stability of local endoscopic hemostasis and an increased risk of recurrent bleeding compared with standard antihypertensive therapy (the studied groups are represented, respectively, 100% each).

Conclusions. We have analyzed the C-reactive protein, interleukin-6 and interleukin-4. The main result of the study was the identification of the dynamics of markers in groups A and B. On the seventh day, normalization of these indicators was not revealed (in group B, it was especially pronounced). But the state of the latter was influenced by the therapy of concomitant pathology in patients with cardiovascular pathology. The clinical significance of immune indicators has been proven in many clinical examples and can be one of the objective criteria for assessing the patient’s condition, predicting the disease and correcting the treatment started.
Perlindungan Hak Alimentasi Bagi Lansia di Panti Sosial Tresna Werdha (PSTW) Budi Mulia 1, Jakarta Timur
Authors: Mutiarany Mutiarany , Anjani Riri Ajeng
Published: January 2022

Setiap manusia merupakan pendukung hak dan kewajiban yang sudah dimiliki pada saat manusia itu dilahirkan dan berakhir pada saat meninggal dunia. Dalam hukum keluarga alimentasi merupakan kewajiban bagi anak untuk memelihara orang tuanya seperti memberikan penafkahan dan memberikan bantuan mengingat usia 60 tahun atau lebih adalah fase di mana seseorang memasuki masa lanjut usia yang membutuhkan bantuan orang lain yang dikarenakan tidak semua lansia dapat melakukan kegiatan seorang diri, dan sangat membutuhkan kasih sayang dari anak-anaknya, maka dari itu adanya hak alimentasi yang wajib dilakukan oleh seorang anak. Hal tersebut dijelaskan dalam Pasal 46 Undang-Undang Nomor 1 Tahun 1974 tentang Perkawinan. Tujuan penulis ingin menjelaskan hak alimentasi beserta akibat hukum bagi lansia yang hak-haknya tidak dipenuhi oleh anak-anaknya. Dalam hal ini penulis melakukan pendekatan kualitatif melalui observasi dan wawancara di Panti Sosial Tresna Werdha (PSTW) Budi Mulia 1, Jakarta Timur. PSWT memberikan pelayanan sosial, psikologis, perawatan medis, bimbingan fisik, mental, spiritual dan bimbingan pemanfaatan waktu luang yang bertujuan untuk meningkatkan taraf kesejahteraan, kualitas hidup dan keberfungsian sosial lansia terlantar sehingga dapat membuat hari tuanya dengan mengikuti ketenteraman lahir dan batin.
The limiting state of bodies during separation in the case of the general plane problem
Authors: Матвеева Алёна Николаевна , Матвеев Сергей Владимирович
Published: January 2022

Работа посвящена решению общей плоской задачи, связанной с определением предельного состояния тел при отрыве. Уравнения, определяющие условия предельного состояния принимаются функциями, зависящими от среднего давления и направлений отрыва. В результате вычислений были получены характеристические уравнения для двух случаев: при достижении предельных значений отрыва двумя главными напряжениями и при достижении предельного значения отрыва одним главным напряжением. Для двух рассмотренных случаев были получены уравнения характеристик и соотношения вдоль них.

The work is devoted to the solution of the general plane problem related to the determination of the limiting state of bodies during separation. The equations defining the conditions for the limiting state are taken as functions that depend on the average pressure and directions of separation. As a result of calculations, the characteristic equations were determined for two cases: when the limiting values of separation by two main stresses are reached and when the limiting value of separation by one main stress is reached. For the two considered cases, equations of characteristics and relations along them were obtained.
Analytical solution of a class of nonlinear differential equations of the third order in the complex area
Authors: Орлов Виктор Николаевич , Мустафина Людмила Витальевна
Published: January 2022

В работе приводится доказательство теоремы существования и единственности аналитического решения класса нелинейных дифференциальных уравнений третьего порядка, правая часть которого представлена полиномом шестой степени, в комплексной области. Расширен класс рассматриваемых уравнений за счет новой замены переменных. Получена априорная оценка аналитического приближенного решения. Представлен вариант численного эксперимента оптимизации априорных оценок с помощью апостериорных.

The article presents a proof of the theorem of the existence and uniqueness of the analytical solution of the class of nonlinear differential equations of the third order, with a polynomial right-hand side of the sixth degree, in the complex domain. The class of the considered equations has been extended by means of a new change of variables. An a priori estimate of the analytical approximate solution is obtained. A variant of the numerical experiment of optimizing a priori estimates using a posteriori estimates is presented.
On the statements of boundary conditions in models of the woven materials production
Authors: Ковалев Владимир Александрович , Мурашкин Евгений Валерьевич
Published: January 2022

В статье обсуждаются проблемы постановка краевых задач при моделировании процессов аддитивного производства 3D материала, при учете наличия в нем дополнительных выделенных направлений (выкладки волокон в тканых материалах, арматуры в бетонных конструкциях, биоволокон в мышечной ткани и т.д.). Выводится общая форма тензорного соотношения на поверхности наращивания, при учете дополнительного выделенного направления. Определяется необходимая система независимых аргументов определяющей тензорной функции на поверхности наращивания в рассматриваемом случае. Определяется полный набор совместных рациональных инвариантов тензора напряжений и характерных директоров. Дается инвариантно-полная формулировка определяющих соотношений на поверхности наращивания. Предложены постановки краевых задач, моделирующих процессы синтеза тканых 3D материалов. Полученные дифференциальные ограничения конкретизируются для ортогональных систем координат, учитывающих геометрию процесса наращивания.

The article discusses the problem of boundary value problems in models of the additive production processes of a 3D material, taking into account the presence of additional selected directions in it (laying out fibers in woven materials, reinforcement in concrete structures, biofibers in muscle tissue, etc.). The general form of the tensor relation on the growing surface is shown, taking into account the additional selected direction. The necessary system of independent arguments of the constitutive tensor function on the growing surface in the considered case is determined. A complete set of joint rational invariants of the stress tensor and characteristic directors is determined. An invariant-complete formulation of the constitutive relations on the growing surface is given. The formulation of boundary value problems that simulate the processes of synthesis of woven 3D materials are proposed. The resulting differential constraints are specified for orthogonal coordinate systems taking account of the geometry of the growing process.
The generalized stokes integral theorem for a covariant pseudotensor field
Authors: Мурашкин Евгений Валерьевич , Радаев Юрий Николаевич
Published: January 2022

Ориентируемые континуумы играют важную роль в микрополярной теории упругости, все реализации которой возможны только в рамках псевдотензорного формализма и представления об ориентируемом многообразии. Особенно это касается теории микрополярных гемитропных упругих сред. В настоящей работе рассматриваются различные формулировки интегральной теоремы Стокса для асимметричного ковариантного пседотензорного поля, заданного веса. Тем самым достигается распространение известной интегральной формулы Стокса на случай псевдотензоров. Последнее обстоятельство позволяет использовать, указанное обобщение для микрополярных континуумов. Исследование существенно опирается на класс специальных координатных систем.

Oriented continua play an important role in the micropolar theory of elasticity, all realizations of which are possible only within the framework of the pseudotensor formalism and the orientable manifold concept. This especially concerns the theory of micropolar hemitropic elastic media. In this paper, we consider various formulations of the Stokes integral theorem for an asymmetric covariant pseudotensor field of a given weight. This extends the well-known Stokes integral formula to the case of pseudotensors. The latter circumstance makes it possible to use the manifistated generalization for micropolar continua. The study relies heavily on the class of special coordinate systems.
Molecular phylogeny and taxonomy of the Hydrangea serrata complex (Hydrangeaceae) in western Japan, including a new subspecies of H. acuminata from Yakushima
Authors: Hirota Shun K. , Yahara Tetsukazu , Fuse Kengo , Sato Hiroyuki , Tagane Shuichiro , Fujii Shinji , Minamitani Tadashi , Suyama Yoshihisa
Published: January 2022

According to the contemporary classification of Hydrangea native to Japan, H. serrata is a polymorphic species including six varieties. We discovered a plant identified as H. serrata, but morphologically distinct from previously known varieties, in Yakushima island where approximately 50 endemic species are known. To determine the relationship of this plant with previously known varieties, we examined morphology and constructed a highly resolved phylogeny of H. serrata and its relatives using three chloroplast genomic regions, rbcL, trnL intron, psbA-trnH, and two nuclear genomic regions, ITS1 and ITS2, and Multiplex ISSR genotyping by sequencing (MIG-seq). Based on these morphological and phylogenetic observations, we describe Hydrangea acuminata subsp. yakushimensissubsp. nov. as a newly discovered lineage in Yakushima, Japan and propose Hydrangea minamitaniistat. nov. and Hydrangea acuminata subsp. australisstat. nov. which were previously treated as varieties of H. serrata.
Le Cercle de sécurité parental, une intervention prometteuse pour le développement de la fonction réflexive parentale
Authors: Lemieux Noémie , Bisaillon Claud
Published: January 2022

La présente étude a pour objectif d’examiner l’efficacité de l’intervention Cercle de sécurité parental (COSP) (Cooper, et al. , 2009) qui vise à favoriser un attachement sécurisant chez les enfants d’âge préscolaire, notamment en stimulant le développement de la fonction réflexive parentale (FRP). Deux groupes de 12 mères ont été soumis à des mesures pré- et post-test, l’un d’eux ayant reçu l’intervention et l’autre non. Les résultats ont révélé une augmentation de la FRP chez les mères ayant reçu l’intervention alors qu’aucun effet n’a été observé chez les mères du groupe de contrôle, suggérant ainsi que l’augmentation est attribuable à l’intervention. Ces résultats confirment les bienfaits de l’intervention auprès d’une population à faible risque et appuient son utilisation au sein des services publics de première ligne et communautaires.
Wear of a Highly Cross-Linked Polyethylene Liner of the Acetabular Component Placed With Excessive Acetabular Inclination
Authors: Tanaka Shigeyuki , Ito Hideya
Published: January 2022

Few studies have investigated the influence of excessive acetabular inclination during total hip arthroplasty (THA) on the wear of highly cross-linked polyethylene (HXLPE). The goal of this study was to determine whether excessive acetabular inclination during THA causes prominent wear of the HXLPE liner. We retrospectively evaluated 62 hips of 54 women and 8 men who underwent primary THA with an HXLPE liner between January 2006 and September 2011. Postoperative anteroposterior pelvic radiographs were used to measure acetabular inclination and analyze polyethylene wear. Patients were divided into the following groups: the excessive acetabular inclination group (acetabular inclination angle ≥50°; n=20) and the control group (acetabular inclination angle <50°; n=42). Clinical information and imaging findings were compared and examined between the 2 groups. Further, we evaluated the correlation between the acetabular inclination angle and the polyethylene wear rate. In all cases, mean follow-up duration was 6.3 years. The annual liner wear was 0.00446 and 0.0254 mm/y in the control and excessive acetabular inclination groups, respectively. The excessive acetabular inclination group had significantly higher polyethylene liner wear compared with the control group (
P
=.00991). A weak correlation was seen between acetabular inclination angle and polyethylene wear rate in all cases (Spearman's rank correlation,
r
=0.283,
P
=.0258). Excessive acetabular inclination may increase HXLPE liner wear in the long term. [
Orthopedics
. 2022;45(2):e96–e100.]
Outcomes of Hardware Removal Surgery for Children
Authors: Ryan Colton , Dunleavy Mark L. , Burton Alex , Hennrikus William
Published: January 2022

Hardware removal is among the most common orthopedic procedures performed in the United States. The goal of this study was to report the outcomes of deep hardware removal for children. This study received institutional review board approval. Patients younger than 18 years who underwent deep hardware removal between 2007 and 2017 were studied. We reviewed 227 procedures involving 132 boys and 95 girls. Mean follow-up was 25 months (range, 14–36 months). Mean age at the time of surgery was 12.8 years (range, 2–17 years). Mean time from initial surgery to hardware removal was 8.4 months (range, 1–72 months). Of the 227 cases, 75 used a tourniquet. Mean tourniquet time was 30.1 minutes (range, 1–118 minutes). Mean length of surgery was 44.0 minutes (range, 4–173 minutes). Mean resident level performing the surgery was postgraduate year 3 (range, postgraduate year 2 to fellow). There were 3 complications. Locations of the implanted hardware included: femur, 85; humerus, 49; tibia, 46; hip/pelvis, 17; ulna, 11; miscellaneous foot, 10; radius, 6; and fibula, 3. Indications for surgery included surgeon recommendations in 122 cases; symptomatic hardware in 68 cases, and parent wishes in 37 cases. Hardware removal for children was safe, and the outcomes were excellent. Complications of hardware removal at a teaching hospital can be minimized when a more senior resident is the primary surgeon. Despite the challenging and historically troublesome nature of deep hardware removal, the current study shows that hardware removal for children is safe and effective. [
Orthopedics
. 2022;45(2):e91–e95.]
Readability and Variability Among Online Resources for Patella Dislocation: What Patients Are Reading
Authors: Echuri Harika , Wendell Cole W. , Brown Symone , Mulcahey Mary K.
Published: January 2022

The purpose of this study was to evaluate the readability, content, and authorship of websites related to patella instability. A search was performed using three search engines and four terms related to patella dislocation. Thirty-seven unique websites were identified. Seventeen of 37 (46%) websites disclosed the authorship credentials. The mean Flesch-Kincaid grade was 10.8±3.5, and the mean Flesch reading ease score was 47.6±18. Only 8 of 37 (22%) websites had a third-party Health On the Net seal. The information presented online about patella dislocation can be unreliable and misleading for patients. [
Orthopedics
. 2022;45(2):e62–e66.]
Improving Health Equity and Reducing Pediatric Cancer Disparities: The Role of the Medical Home
Authors: Rodriguez-Hernandez Alexandra , Kahn Justine M.
Published: January 2022

The advances in pediatric cancer outcomes over the last quarter century are some of the most successful in modern medicine. Improved diagnostics and novel therapies have led to continued increases in the survival rates of most patients; however, not all populations have benefitted equally. Compared to White children, Black, Indigenous, People of Color patients with cancer more often present with advanced stage illness, less frequently participate in clinical trials, and are more likely to be lost to follow-up once therapy is complete. Proposed hypotheses for these disparities include both biologic and nonbiologic factors, and a growing body of research suggests that barriers influencing care from diagnosis through survivorship are important. In this article, we consider how primary pediatricians can help reduce disparities over the cancer continuum by identifying vulnerable populations, considering potential diagnoses, referring to cancer centers, and following up with patients through survivorship in partnership with the oncology team.

[
Pediatr Ann
. 2022;51(1):e22–e26.]
Adolescents and Young Adults with Cancer: Survivorship and Special Considerations
Authors: Joffe Lenat , Steinberg Dara M. , Strohli Tiffany , Beauchemin Melissa
Published: January 2022

Adolescents and young adults (AYAs) who have cancer face a distinct set of challenges beginning during the initial diagnosis, extending throughout treatment, and continuing into survivorship. Owing to significant strides made in cancer therapy in recent decades, more than 80% of this group will go on to become long-term survivors. Despite these improvements, however, many AYAs continue to have poorer outcomes when compared with older and younger patients. The purpose of this article is to underscore the unique set of multifaceted obstacles that this vulnerable group encounters and to pinpoint critical areas of attention and intervention throughout the health care journey. Moreover, it aims to highlight the importance of the role of the primary care provider as a constant partner in safeguarding the long-term physical and mental health of this diverse population within a complex and, at times, trying health care system.

[
Pediatr Ann
. 2022;51(1):e27–e33.]
Evolving Strategies in the Management of Sickle Cell Disease in the 21st Century and the Role of the Pediatrician
Authors: Hardit Viney , Alvarez Ofelia , Ziga Edward , Alperstein Warren
Published: January 2022

Sickle cell disease (SCD) is one of the most common genetic disorders in the United States. Once a fatal disease of childhood, the majority of patients born with SCD who live in a developed country will survive to adulthood (albeit with slightly shortened life spans). Despite numerous novel therapeutic advancements in recent years that serve to mitigate the symptoms associated with SCD, the only cure for SCD is a hematopoietic stem cell transplant. The overall survival for patients with a matched sibling donor transplant is greater than 90%. However, fewer than 20% of patients with SCD in the US have a 12/12 human leukocyte antigen (HLA) matched sibling donor. In contrast, most patients have at least one HLA haploidentical first-degree relative, which expands the donor pool for patients who have diseases amenable to stem cell transplantation such as SCD.

[
Pediatr Ann
. 2022;51(1):e34–e39.]
Investigation of ZnO doping on LaFeO3/Fe2O3 prepared from yarosite mineral extraction for ethanol gas sensor applications
Authors: Suhendi Endi ,   Physics Study Program, Universitas Pendidikan Indonesia, Bandung, Indonesia, Putri Andini Eka , Ulhakim Muhamad Taufik , Setiawan Andhy , Dani Gustaman Syarif ,   Center of Science and Technology of Applied Nuclear, National Nuclear Energy Agency of Indonesia (BATAN), Bandung, Indonesia
Published: January 2022

In this study, we used a natural resource, yarosite minerals, as a Fe2O3 precursor. Yarosite minerals were used for the synthesis of LaFeO3/Fe2O3 doped with ZnO via a co-precipitation method using ammonium hydroxide, which produced a light brown powder. Then, an ethanol gas sensor was prepared using a screen-printing technique and characterized using gas chamber tools at 100,200, and 300 ppm of ethanol gas to investigate the sensor's performance. Several factors that substantiate electrical properties such as crystal and morphological structures were also studied using X-Ray Diffraction (XRD) and Scanning Electron Microscopy (SEM), respectively. The crystallite size decreased from about 61.4 nm to 28.8 nm after 0.5 mol% ZnO was added. The SEM characterization images informed that the modified LaFeO3 was relatively the same but not uniform. Lastly, the sensor's electrical properties exhibited a high response of about 257% to 309% at an operating temperature that decreased from 205 ℃ to 180 ℃. This finding showed that these natural resources have the potential to be applied in the development of ethanol gas sensors in the future. Hence, yarosite minerals can be considered a good natural resource that can be further explored to produce an ethanol gas sensor with more sensitive response. In addition, this method reduces the cost of material purchase.
Characterizations of intra-regular LA-semihyperrings in terms of their hyperideals
Authors: Nakkhasen Warud ,   Department of Mathematics, Faculty of Science, Mahasarakham University, Maha Sarakham 44150, Thailand
Published: January 2022

The purpose of this article is to investigate the class of intra-regular $ LA $-semihyperrings. Then, characterizations of intra-regular $ LA $-semihyperrings by the properties of many types of their hyperideals are obtained. Moreover, we present a construction of $ LA $-semihyperrings from ordered $ LA $-semirings.
Enzymatic pre-treatment of grape seeds for an oil with higher antioxidant activity
Authors: Tociu M. , Hirtopeanu A. , Stanescu M.D.
Published: January 2022

The paper investigates the effect of the enzymatic pre-treatment of grape seeds from six Romanian cultivars on the oil extracted. The grape seeds of some white and red Romanian grape varieties were separated from winery waste, washed, dried and ground, with the oil then obtained by extraction with petroleum ether. The extraction was performed directly or after a preliminary treatment with a commercial pectin lyase. The enzymatic procedure applied was more cost effective compared to other treatments previously described in which a cocktail of enzymes was used. The quantity of the extracted oil was measured in both types of processing, with an increase being observed for pre-treated samples. The fatty acid profiles (FAPs) of the oils resulted for the treated and untreated seeds were determined. No change in the composition was noticed. The reductive power of these oils was also investigated. Compared to the untreated samples for the same variety, the enzyme pre-treatment resulted in a superior antioxidant capacity.
A novel bleaching approach: Microwave assisted sunflower oil bleaching and optimization
Authors: Seçilmiş Ş. S. , Koçak Yanık D. , Fadıloğlu S. , Göğüş F.
Published: January 2022

The factors affecting the microwave bleaching of sunflower oil and the interaction between them were investigated and optimized by response surface methodology using a three-factor five-level central composite rotatable design. Microwave power, time and the amount of bleaching clay were selected as independent variables studied in the range of 70-120 W, 2-15 min, and 0.01-0.5%. The dependent variables that measure the bleaching efficiency and oil quality were evaluated as hue angle, chroma and totox value. Optimization was carried out by minimizing totox and chroma and maximizing hue angle. Hue angle, chroma and totox were found as 96.91, 37.66 and 23.31 under optimal conditions. Optimal microwave bleaching was successfully performed by using less bleaching clay (0.4%) and a shorter time (8 min) compared to the current industrial application without any adverse effect on oil quality. Hence, microwave bleaching is thought to be an alternative method for the bleaching of edible oils.
Religious tourism in municipalities in the state of Amazonas
Authors: S. B. Teixeira Maria Adriana , Barbosa Santos Lúcia Cláudia , Ramos Iwata Maria Jacqueline , Peixoto de Oliveira Anny Gabrielly
Published: January 2022

This study deals with the main religious aspects of three major events that propagate religious tourism in the state of Amazonas. Religious tourism is driven by the religious particularities of each tourist, who seek places considered sacred and recognized for their acts of faith, as well as for the graces achieved. The general objective of the study is to analyze the main characteristics of the religious tourism of Nossa Senhora do Carmo (Parintins); The feast of Santo Antônio de Borba (Borba) and Nossa Rainha do Rosário (Itapiranga). The results showed that the main characteristics of the studied events are to keep the religious traditions passed down from generations, to strengthen the devotion to the local patron saint and to
Policies and Innovations of Financial Technology Business Models in the Digital Economy Era on the E-Business Ecosystem in Indonesia
Authors: Setiawan Ahmad Budi , Dunan Amri , Mudjianto Bambang
Published: January 2022

The rapid development of technology and information systems continues to give birth to various innovations, especially those related to financial technology to meet the various needs of the community, including access to financial services and processing of financial transactions. Financial technology (FinTech) is the implementation and utilization of technology to improve financial and banking services. The development of financial technology in Indonesia itself is growing rapidly, along with the development of existing technology. FinTech is developed by utilizing the latest software, internet, and computing technologies. Based on this, this study examines the development of innovation and policies for the fintech business model in the e-business ecosystem in Indonesia. This research is a qualitative research with data collection methods through focus group discussions, in-depth interviews, and literature studies. This chapter recommends that the government develop and make policies for fintech business model innovation in the e-business ecosystem in Indonesia.
Advanced Technological Factors Affecting Digital Banking Usage Intention
Authors: Chen Chua (Jane) Soh , Dastane Omkar
Published: January 2022

This research-based chapter investigates impact of various innovation technology factors on digital banking customers' usage intention. The selected factors are online banking, mobile payment, artificial intelligence-based robot advisors, and cloud-based services. The study develops conceptual model against theoretical background of the innovation diffusion theory, technology acceptance model, and unified theory of acceptance and use of technology. Empirical data was collected through online survey using a self-administered questionnaire. Quantitative research method was employed with a total sample size of 302 respondents using snowball sampling technique. Normality and reliability tests were performed followed by confirmatory factory analysis, validity assessment, and structural equation modelling using AMOS 24. The findings confirm positive significant impact of artificial intelligence-based robot advisor and cloud-based services on usage intention. Theoretical contribution and managerial implications are then discussed along with limitations of the current study and future research avenues.
Factors Affecting on IoT-Based Business Management in the Post-Pandemic Period
Authors: Miraz Mahadi Hasan , Saleheen Ferdoush , Almunawar Mohammad Nabil , Sumi Farhana Rahman , Sarkar Shumi , Hasan Mohammad Tariq
Published: January 2022

This research examines the relationship between facilitating condition, digital literacy, pandemic adoption, social influence, application use intention, and IoT-based business. Also, the research used systematic random sampling in this study to achieve the most rigorous analysis of the possible research objectives even though 277 legitimate replies were received in response to the survey questions asked at the online-based companies in Bangladesh. The scope of this study is the urban SME industry in Bangladesh. Besides that, the data was being analyzed with the help of partial least squares structural equation modeling (PLS-SEM). These research findings showed that facilitating condition (FC), digital literacy (DL), pandemic adoption (PA), social influence (SI), application use intention (AUI), and IoT-based business (dependent variable) effect in SME business industries in Bangladesh.
Sustainability and Consumerism
Authors: Banerjee Subhanil , Gupta Shilpi , Koner Souren
Published: January 2022

The Brundtland Commission report Our Common Future in 1987 gave birth to the concept of sustainable development. The meaning is benefitting the present without compromising the future. It was felt that, unless conventional growth and development are replaced by sustainable development through environmentally friendly actions, doomsday is very near. However, such sustainable development was followed by a global spree of consumerism that only added to the environmental burden. This dichotomy needs to be understood, and for the same purpose, one needs to go back to that point of Earth's history when ecology and economy were synonymous. From then on, the drift between the ecology and economy that has brought us to today's scenario needs to be understood. In this background, the chapter raises questions on how green the green sectors are. Furthermore, can sustainable development and consumerism be captured as one body of ‘sustainable consumerism'?
How Responsible Are Consumers?
Authors: Kapoor Namita
Published: January 2022

One of the most important concern the economies are facing is food security amidst the growing population. The population growth has exerted tremendous pressure on food security and has raised concerns over food sustainability. The sustainability of food waste is an environmental, economic, and social issue, which has useful policy implications. The issue has been studied through the analysis of responsible consumption and food waste. The literature has emphasised improving the efficiency in supply chain to reduce food waste, but researches on food waste at the consumer level are still in the natal stage. It is important to understand to develop the framework for responsible consumption and to assess the factors that may contribute to reduction in food waste at the household level. The study aims to examine the scope of responsible consumption to attain environmental sustainability.
The Effect of Chinese Green Transformation on Competitiveness and the Environment
Authors: Yu Poshan , Jiao Andong , Sampat Michael
Published: January 2022

People in China are paying more attention to environmental issues as they increase in importance and consequence. At the same time, the Chinese government has gradually begun paying more attention to the environment, advocating sustainable development. The government has been actively developing green financial products such as green loans, green insurance, green funds, and other financial products to help Chinese companies “go green” and reach peak carbon and carbon-neutral goals ahead of schedule. China attaches great importance to its “green transformation” goals, as can be seen from the number of new policies related to green and sustainable development. Under these circumstances, companies must follow the policy and carry out green upgrades or risk total failure. This chapter mainly discusses the background of what firms face in China's green finance environment, taking clean energy, green buildings, and green transportation as examples of how companies should adapt to these trends and improve their competitiveness.
Market Segmentation and Dark Tourism and the (Post) Pandemic Scenario
Authors: Veiga João Miguel , Veloso João Daniel , Pereira Sara Quintão , Sousa Bruno Barbosa
Published: January 2022

Dark tourism is a segment of tourism that has been growing in recent decades and is strongly associated with tragedy and mystery. There are several academic researchers who present literature on this specific group of tourist consumers. As a result, 2020 was strongly marked by the pandemic of the new coronavirus (COVID-19). This chapter presents a reflection on the role of dark tourism in the pandemic and post-pandemic period. From an interdisciplinary perspective, this chapter presents contributions to (dark) tourism, marketing, and pandemic management.
Complex effects of acidification, habitat properties and fish stock on littoral macroinvertebrate assemblages in montane standing waters
Authors: Petruželová Jana , Bojková Jindřiška , Sychra Jan , Šorfová Vanda , Polášková Vendula , Vrba Jaroslav
Published: January 2022

Littoral macroinvertebrates in acidified waterbodies are affected by the interaction of acidification and local environmental conditions. Understanding the interplay of these factors in the structuring of communities is essential for interpreting responses to and/or recovery from acidification. Here, we analyse the species composition and richness of littoral macroinvertebrates in a range of acidified montane standing waters in relation to water chemistry, littoral characteristics and fish stock. The main species composition gradients were related to pH and conductivity; however, considerable variation along these gradients was associated with local habitat characteristics (changing water levels and littoral structure) and concentration of ionic aluminium and dissolved organic carbon. Although fish stock effects were confounded by correlated acidity, we observed a significant decline in abundance of macroinvertebrates vulnerable to fish predation at sites with fish stock. Overall, littoral macroinvertebrates of acidic waterbodies were diverse due to the heterogeneity of local habitat properties, despite they were dominated by acid-tolerant species. Acidic humic sites with dense, heterogeneous littoral vegetation were species-rich, hosting numerous habitat specialists and rare species, while chronically acidified lakes with high aluminium concentrations and sparse littoral vegetation had species-poor assemblages, characteristic of strong acid-stress. Water level manipulation resulted in serious assemblage impoverishment, overriding the effects of more favourable water chemistry. This study shows that the littoral fauna of acidic waterbodies is structured by complex effects induced by local factors in addition to acidity, resulting in acid-stressed assemblages with relatively high variability, emphasising a need to analyse local habitat factors when evaluating the impact of acidification on macroinvertebrates.
Connection between the Plasma Level of Apelin and Diabetic Nephropathy in Type 2 Diabetic Patients. A Case Control Study
Authors: Helmy Mona Yousry , Hamdy Nehal , Ghaffar Nagwa Abd El
Published: January 2022

Background:

Apelin is an adipokine that may have an advantageous role in the prediction of early diabetic nephropathy. A few studies on apelin in diabetes have been performed and this research was performed to establish the connection between the apelinergic system and diabetic nephropathy.

Materials and Methods:

The research included 60 patients with type 2 diabetes mellitus (T2DM) who were equally divided into Group-I (diabetic nephropathy) and Group-II (non-diabetic nephropathy), and 30 healthy subjects in the control group (Group-III). Body mass index (BMI) and waist circumference were calculated. FBG, 2 h–PPG, HbA1c, fasting lipids, urea, creatinine, eGFR, urine analysis, A/C ratio, and apelin levels were assessed.

Results:

A statistically significant between-group difference in plasma apelin levels was found (P< 0.001). Apelin was the highest in Group-I than in Group-II relative to Group-III (325.79 ± 59.42 pg/mL, 162.83 ± 29.88 pg/mL, and 77.43 ± 8.44 pg/mL, respectively). Among diabetic patients, plasma apelin had a significantly positive correlation with disease duration (r= 0.612), SBP (r =0.427), DBP (r= 0.466), weight (r= 0.372), and height (r= 0.372), FBG (r= 0.684), 2 h-PPG (r= 0.744), HbA1C (r= 0.890), total (T)-cholesterol (r= 0.316), low density lipoprotein (LDL)-C (r= 0.397), urea (r= 0.575), and creatinine (r= 0.591). A significantly negative correlation was observed between plasma apelin and HDL-C (r= –0.303), and eGFR (r= –0.566).

Conclusion:

Apelin levels in diabetics were elevated in the case of nephropathy, impaired glucose tolerance, and dyslipidemia. This supports the relationship between the apelinergic system and diabetic nephropathy.
Multiple myeloma: Unveiling the survival data with different lines of treatments
Authors: Kurian Helan , Abraham Suja , Antony Arpith , Jiju Jeeva Ann , Thomas Timy
Published: January 2022

Purpose:

The incidence of multiple myeloma (MM) is rising and there are fewer Indian studies; a comprehensive research of MM patients’ survival data in a real-world population is needed. This study aims to analyze the survival status of MM patients with different treatment regimens along with its correlation to other parameters such as treatment-free interval (TFI) and time-to-next treatment (TTNT).

Materials and Methods:

This was a retrospective observational study, done in the department of oncology, at a tertiary care hospital in Kerala, from August 2019 to July 2020, to analyze the survival data in patients diagnosed with MM from 2015 to 2019. The effectiveness endpoints include time-to-event analyses such as TTNT and TFI. After receiving various therapy regimens, the survival rates were analyzed; the Kaplan–Meier estimator was used to determine the cumulative survival. The correlations between overall survival (OS) and duration of therapy, TFI, TTNT, and other parameters were calculated using the Karl Pearson’s correlation coefficient.

Results:

72 (82.80%) of the patients survived to the end of the study (OS), with a mean survival time of 4.02 ± 2.81 years. 52 (59.80%) patients had progression-free survival (PFS), while the remaining 35 (40.22%) had no significant disease prognosis. Both OS and PFS showed a significant positive correlation (P > 0.05) with TTNT and TFI.

Conclusions:

Completely adherent chemotherapy for 1 year can promise a survival time not <2 years. Longer TFI resulted in better OS and PFS. Extending the duration of the second LOT correlated with the better OS and PFS.