bluuebunny/crossref_metadata_2025 huggingface dataset:
Emotions and brain function are altered up to one month after a single high dose of psilocybin
Authors: Barrett Frederick S. , Doss Manoj K. , Sepeda Nathan D. , Pekar James J. , Griffiths Roland R.
Published: February 2020

Psilocybin is a classic psychedelic compound that may have efficacy for the treatment of mood and substance use disorders. Acute psilocybin effects include reduced negative mood, increased positive mood, and reduced amygdala response to negative affective stimuli. However, no study has investigated the long-term, enduring impact of psilocybin on negative affect and associated brain function. Twelve healthy volunteers (7F/5M) completed an open-label pilot study including assessments 1-day before, 1-week after, and 1-month after receiving a 25 mg/70 kg dose of psilocybin to test the hypothesis that psilocybin administration leads to enduring changes in affect and neural correlates of affect. One-week post-psilocybin, negative affect and amygdala response to facial affect stimuli were reduced, whereas positive affect and dorsal lateral prefrontal and medial orbitofrontal cortex responses to emotionally-conflicting stimuli were increased. One-month post-psilocybin, negative affective and amygdala response to facial affect stimuli returned to baseline levels while positive affect remained elevated, and trait anxiety was reduced. Finally, the number of significant resting-state functional connections across the brain increased from baseline to 1-week and 1-month post-psilocybin. These preliminary findings suggest that psilocybin may increase emotional and brain plasticity, and the reported findings support the hypothesis that negative affect may be a therapeutic target for psilocybin.
Melatonin controls microbiota in colitis by goblet cell differentiation and antimicrobial peptide production through Toll-like receptor 4 signalling
Authors: Kim Seung Won , Kim Soochan , Son Mijeong , Cheon Jae Hee , Park Young Sook
Published: February 2020

Microbial dysbiosis has long been postulated to be associated with the pathogenesis of inflammatory bowel disease (IBD). Although evidence supporting the anti-colitic effects of melatonin have been accumulating, it is not clear how melatonin affects the microbiota. Herein, we investigated the effects of melatonin on the microbiome in colitis and identified involvement of Toll-like receptor (TLR) 4 signalling in the effects. Melatonin improved dextran sulfate sodium (DSS)-induced colitis and reverted microbial dysbiosis in wild-type (WT) mice but not in TLR4 knockout (KO) mice. Induction of goblet cells was observed with melatonin administration, which was accompanied by suppression ofIl1bandIl17aand induction of melatonin receptor and Reg3β, an antimicrobial peptide (AMP) against Gram-negative bacteria.In vitro, melatonin treatment of HT-29 intestinal epithelial cells promotes mucin and wound healing and inhibits growth ofEscherichia coli. Herein, we showed that melatonin significantly increases goblet cells, Reg3β, and the ratio ofFirmicutestoBacteriodetesby suppressing Gram-negative bacteria through TLR4 signalling. Our study suggests that sensing of bacteria through TLR4 and regulation of bacteria through altered goblet cells and AMPs is involved in the anti-colitic effects of melatonin. Melatonin may have use in therapeutics for IBD.
Regional nutrient decrease drove redox stabilisation and metazoan diversification in the late Ediacaran Nama Group, Namibia
Authors: Bowyer F. T. , Shore A. J. , Wood R. A. , Alcott L. J. , Thomas A. L. , Butler I. B. , Curtis A. , Hainanan S. , Curtis-Walcott S. , Penny A. M. , Poulton S. W.
Published: February 2020

The late Ediacaran witnessed an increase in metazoan diversity and ecological complexity, marking the inception of the Cambrian Explosion. To constrain the drivers of this diversification, we combine redox and nutrient data for two shelf transects, with an inventory of biotic diversity and distribution from the Nama Group, Namibia (~550 to ~538 Million years ago; Ma). Unstable marine redox conditions characterised all water depths in inner to outer ramp settings from ~550 to 547 Ma, when the first skeletal metazoans appeared. However, a marked deepening of the redoxcline and a reduced frequency of anoxic incursions onto the inner to mid-ramp is recorded from ~547 Ma onwards, with full ventilation of the outer ramp by ~542 Ma. Phosphorus speciation data show that, whilst anoxic ferruginous conditions were initially conducive to the drawdown of bioavailable phosphorus, they also permitted a limited degree of phosphorus recycling back to the water column. A long-term decrease in nutrient delivery from continental weathering, coupled with a possible decrease in upwelling, led to the gradual ventilation of the Nama Group basins. This, in turn, further decreased anoxic recycling of bioavailable phosphorus to the water column, promoting the development of stable oxic conditions and the radiation of new mobile taxa.
Association between uric acid and brachial-ankle pulse wave velocity: secondary analysis of data from a cross-sectional study
Authors: Luo Faxin , Zhuo Chaozhou
Published: February 2020

At present, the association between uric acid (UA) and brachial-ankle pulse wave velocity (baPWV) has not been well clarified. This study is the second analysis based on a cross-sectional study. 912 participants (average age is 51.5 ± 9.6 years) who underwent medical health examinations were included in this study, UA levels and baPWV were measured. Participants were divided into four groups according to UA levels (Quantile 1: 2.00–4.10 mg/dL; Quantile 2: 4.20–5.20 mg/dL; Quantile 3: 5.30–6.00 mg/dL and Quantile 4: 6.10–9.80 mg/dL), and the differences of baPWV between the four groups were compared. Univariate analysis showed a positive correlation between UA and baPWV [(Quantile 2 vs Quantile 1: 8.85 (−36.05, 53.75); Quantile 3 vs Quantile 1: 60.32 (13.22, 107.42) and Quantile 4 vs Quantile 1: 80.34 (36.19, 124.49)]. After adjusting for confounding factors, the positive correlation between UA and baPWV still exists [(Quantile 2 vs Quantile 1: −9.92 (−60.16, 40.32); Quantile 3 vs Quantile 1: 82.34 (4.00, 160.68) and Quantile 4 vs Quantile 1: 143.13 (0.75, 285.51)]. Furthermore, curve fitting showed that UA and baPWV had a non-linear positive correlation. In conclusion, elevated UA were associated with baPWV, suggesting that UA could be used as a predictor of atherosclerosis.
Two-dimensional infrared spectroscopy: an emerging analytical tool?
Authors: Fritzsch Robby , Hume Samantha , Minnes Lucy , Baker Matthew J. , Burley Glenn A. , Hunt Neil T.
Published: February 2020

Recent progress in laser technology and data analysis methods has enabled high throughput applications of ultrafast two-dimensional infrared (2D-IR) spectroscopy measurements and opened the door to analytical applications.
Paper spray mass spectrometry for the analysis of picoliter droplets
Authors: Kaur Kohli Ravleen , Davies James F.
Published: February 2020

Paper spray ionization coupled with high resolution mass spectrometry is shown to be an effective strategy for the analysis of picoliter droplets containing atmospherically-relevant oxygenated organic compounds.
Applications of electrochemical sensors and biosensors based on modified screen-printed electrodes: a review
Authors: Beitollahi Hadi , Mohammadi Sayed Zia , Safaei Mohadeseh , Tajik Somayeh
Published: February 2020

The focus of this report is electroanalysis performedviascreen-printed electrodes.
Urethral reconstruction using an amphiphilic tissue-engineered autologous polyurethane nanofiber scaffold with rapid vascularization function
Authors: Niu Yuqing , Liu Guochang , Chen Chuangbi , Fu Ming , Fu Wen , Zhao Zhang , Xia Huimin , Stadler Florian J.
Published: February 2020

We report the efficient application of a well-layered tubular amphiphilic nanofiber of a polyurethane copolymer (PU-ran) for the regulation the phenotypic expression of epithelial cells (ECs) and smooth muscle cells (SMCs) for vascularized urethral reconstruction.
Mechanical properties of tantalum carbide from high-pressure/high-temperature synthesis and first-principles calculations
Authors: Sun Weiguo , Kuang Xiaoyu , Liang Hao , Xia Xinxin , Zhang Zhengang , Lu Cheng , Hermann Andreas
Published: February 2020

The mechanical strength of ceramic material TaC can be described well with atomistic simulations if realistic deformation models are considered.
Effects of temperature and grain size on deformation of polycrystalline copper–graphene nanolayered composites
Authors: Ma Yunlong , Zhang Sen , Xu Yunfei , Liu Xiaoyi , Luo Sheng-Nian
Published: February 2020

The effects of temperature and grain size on mechanical properties of polycrystalline copper–graphene nanolayered (PCuGNL) composites are investigated by analytical mechanical models and molecular dynamics simulations.
Molecular aspects of organic cations affecting the humidity stability of perovskites
Authors: Kim Bohyung , Seok Sang Il
Published: February 2020

Manipulation of organic cations and dimensional flexibility can improve the humidity stability of perovskites.
A geospatially resolved database of hydraulic fracturing wells for chemical transformation assessment
Authors: Sumner Andrew J. , Plata Desiree L.
Published: February 2020

A database to unify physicochemical parameters of oil and gas wells with chemical additive disclosures helps highlight chemical transformation potential across the United States with geospatial specificity, informing improved industrial practice and environmental assessment.
Selenium-mediated gga-miR-29a-3p regulates LMH cell proliferation, invasion, and migration by targeting COL4A2
Authors: Hu Xueyuan , Tan Siran , Yin Hang , Khoso Pervez Ahmed , Xu Zhe , Li Shu
Published: February 2020

Selenium (Se) is an essential trace element that has several functions in cellular processes related to cancer prevention. While the cancericidal effect of Se has been reported in liver cancer, the mechanism has not been clarified. MiR-29a has widely been reported as a tumor suppressor; however, it also acts as a carcinogenic agent by increasing cell invasion in human epithelial cancer cells and hepatoma cells. In a previous study, we found that miR-29a-3p is a Se-sensitive miRNA. However, its effect in the chicken hepatocellular carcinoma cell line (LMH) is still unknown. In the present study, we found that the expression of miR-29a-3p in LMH cells was decreased by Se supplementation and increased under Se-deficient conditions. Flow cytometry and CCK-8 results suggested that Se decreased LMH cell proliferation induced by miR-29a-3p overexpression. Transwell and gap-closure assays implied that Se mediated LMH cell invasion and migration by downregulating miR-29a-3p. Quantitative real-time polymerase chain reaction and Western blotting results suggested that Se mitigated miR-29a-3p overexpression-induced LMH cell proliferation by downregulating CDK2, cyclin-D1, CDK6, and cyclin-E1. We further demonstrated that collagen type IV alpha 2 (COL4A2) is a target gene of miR-29a-3p. COL4A2 activates the RhoA/ROCK pathway to promote LMH cell invasion and migration. In conclusion, Se mediated miR-29a-3p overexpression induced LMH cell invasion and migration by targeting COL4A2 to inactivate the RhoA/ROCK pathway.
Nanomaterials for the regulation of the tumor microenvironment and theranostics
Authors: Zhen Wenyao , Hu Wenxue , Dong Liang , An Shangjie , Jiang Xiue
Published: February 2020

This review introduces the latest progress in the design of multi-functional nanomedicines for the regulation of the TME and their theranostics.
A simple chemiluminescent aptasensor for the detection of α-fetoprotein based on iron-based metal organic frameworks
Authors: Han Rui , Sun Yuanling , Lin Yanna , Liu Hao , Dai Yuxue , Zhu Xiaodong , Gao Dandan , Wang Xueying , Luo Chuannan
Published: February 2020

MIL-100 (Fe) was used to construct a chemiluminescent aptasensing platform based on the electrostatic adsorption of MIL-100 (Fe) and aptamers.
Palladium fabricated on boehmite as an organic–inorganic hybrid nanocatalyst for C–C cross coupling and homoselective cycloaddition reactions
Authors: Tahmasbi Bahman , Ghorbani-Choghamarani Arash , Moradi Parisa
Published: February 2020

Pd-adenine@boehmite has been prepared and characterized by FT-IR, BET, SEM, EDS, WDX, TGA, XRD and AAS techniques and further was used as catalyst in organic reactions. The reused catalyst was characterized by TEM, EDS, WDX, AAS and FT-IR techniques.
Direct silica coating of drug crystals for ultra-high loading
Authors: Wang Neng , Zhou Weiwei , Yan Miao , Zhang Mengmeng , Wang Hong , Chen Hongyu
Published: February 2020

By directly coating a thin silica shell around the molecular crystal, ultra-high drug loading content (88%) is realized.
Fe doped Ni5P4 nanosheet arrays with rich P vacancies via phase transformation for efficient overall water splitting
Authors: Qi Junlei , Xu Tianxiong , Cao Jian , Guo Shu , Zhong Zhengxiang , Feng Jicai
Published: February 2020

A simple phase transformation strategy to construct rich vacancy defects without special equipment is achieved.
An electrophoretic DNA extraction device using a nanofilter for molecular diagnosis of pathogens
Authors: Kang Jae-Hyun , Kim Yong Tae , Lee Kidan , Kim Hyun-Mi , Lee Kyoung G. , Ahn Junhyoung , Lee JaeJong , Lee Seok Jae , Kim Ki-Bum
Published: February 2020

A simple electrophoretic DNA extraction device has developed using a nanofilter for rapid and efficient DNA aquisition required for point-of-care analysis in order to prevent an epidemic/pandemic disease outbreak.
Controlled polymer crystal/two-dimensional material heterostructures for high-performance photoelectronic applications
Authors: Kim Kang Lib , Koo Min , Park Cheolmin
Published: February 2020

The recent development of thin polymer films fabricated on the surfaces of various 2D nanomaterials for high-performance photoelectronic devices is reviewed, with control of the molecular and crystalline structures of the polymers on the 2D surface.
Synthesis of nanomagnetic sulphonated impregnated Ni/Mn/Na2SiO3 as catalyst for esterification of palm fatty acid distillate
Authors: Ibrahim Naeemah A. , Rashid Umer , Choong Thomas Shean Yaw , Nehdi Imededdine Arbi
Published: February 2020

The acidic EFB was doped with magnetic oxides to produce sulphonated nanomagnetic catalysts for biodiesel production from palm fatty acid distillate (PFAD).
Constructing an ultra-adsorbent based on the porous organic molecules of noria for the highly efficient adsorption of cationic dyes
Authors: Jiang Danyong , Deng Ruiping , Li Gang , Zheng Guoli , Guo Huadong
Published: February 2020

A novel Noria-POP-1 material has been successfully synthesized by simply polymerization of Noria and aryl diamines. Noria-POP-1 displays a remarkable capability to selectively absorb and separate methylene blue, which is 2434 mg g−1.
Effects of three fabric weave textures on the electrochemical and electrical properties of reduced graphene/textile flexible electrodes
Authors: Wang Wei , Li Tao , Liu Kang , Wang Shuo , Peng Huaxin
Published: February 2020

Textile textures formed through woven, knitted or nonwoven weaving technology have critical effects on the electrical and electrochemical properties of flexible electrodes.
Biofunctionalization of zirconia with cell-adhesion peptides via polydopamine crosslinking for soft tissue engineering: effects on the biological behaviors of human gingival fibroblasts and oral bacteria
Authors: Yang Zhen , Liu Mingyue , Yang Yang , Zheng Miao , Yang Yang , Liu Xiaoqiang , Tan Jianguo
Published: February 2020

Biofunctionalization of zirconia with cell-adhesion peptides via polydopamine and its effect on HGFs/bacterial adhesion for enhanced soft tissue seal.
Synthesis, properties and photovoltaic performance in dye-sensitized solar cells of three meso-diphenylbacteriochlorins bearing a dual-function electron-donor
Authors: Chakraborty Subrata , Tsai Ming-Chi , Su Xin-De , Chen Xuan-Cheng , Su Tang-Ting , Tsao Che-Kai , Lin Ching-Yao
Published: February 2020

Synthesis, properties, and photovoltaic performance of three new air-stable, meso-biphenylbacteriochlorins bearing a dual-function donor are reported.
Adsorption of divalent cadmium by calcified iron-embedded carbon beads
Authors: Cheng Yalin , Wang Kaiqian , Tu Biyang , Xue Shan , Deng Jiahui , Tao Haisheng
Published: February 2020

The material structure could prevent Fe nanoparticle agglomeration during synthesis and maintain Fe stability during adsorption. Fe/SA-C had a superior adsorption property and easy recoverability.
Experimental verification of a broadband asymmetric transmission metamaterial in the terahertz region
Authors: Tao Xiang , Qi Limei , Yang Jun , Liu Fanyi
Published: February 2020

In this work, a broadband terahertz asymmetric transmission metamaterial is experimentally demonstrated for a linearly polarized wave.
Regiodivergent construction of medium-sized heterocycles from vinylethylene carbonates and allylidenemalononitriles
Authors: Zhang Xiang , Li Xiang , Li Jun-Long , Wang Qi-Wei , Zou Wen-Lin , Liu Yan-Qing , Jia Zhi-Qiang , Peng Fu , Han Bo
Published: February 2020

Here we report palladium-catalyzed, regiodivergent [5 + 4] and [5 + 2] annulations of vinylethylene carbonates and allylidenemalononitriles affording over 50 medium-sized heterocycles in high isolated yields with excellent regioselectivities.
Surface coating of LiMn2O4 cathodes with garnet electrolytes for improving cycling stability of solid lithium batteries
Authors: Bi Zhijie , Zhao Ning , Ma Lina , Shi Chuan , Fu Zhengqian , Xu Fangfang , Guo Xiangxin
Published: February 2020

LiMn2O4 cathodes coated with garnet electrolytes are constructed for improving cycling stability of solid lithium batteries.
MOF-mimetic molecules: carboxylate-based supramolecular complexes as molecular metal–organic framework analogues
Authors: Decker Gerald E. , Lorzing Gregory R. , Deegan Meaghan M. , Bloch Eric D.
Published: February 2020

This review covers MOF-like molecules, an emerging class of potentially porous, soluble, and discrete cages.
Improving the cycling and air-storage stability of LiNi0.8Co0.1Mn0.1O2 through integrated surface/interface/doping engineering
Authors: Zhai Yanwu , Yang Wenyun , Ning De , Yang Jinbo , Sun Limei , Schuck Götz , Schumacher Gerhard , Liu Xiangfeng
Published: February 2020

Excellent cycling and air-storage stability of LiNi0.8Co0.1Mn0.1O2 are obtained through an integrated strategy with a Li2ZrO3 protective layer, Zr4+ doping and the rock-salt interface phase engineering from Li2ZrO3 coating.
Production of a monoclonal antibody for the detection of vitamin B1 and its use in an indirect enzyme-linked immunosorbent assay and immunochromatographic strip
Authors: Zeng Lu , Wu Xaioling , Liu Liqiang , Xu Liguang , Kuang Hua , Xu Chuanlai
Published: February 2020

A monoclonal antibody (mAb) against vitamin B1 was prepared and based on this, an indirect competitive enzyme-linked immunosorbent assay (ic-ELISA) and colloidal gold-based immunochromatographic test (ICT) strip were developed.
Strengthened relaxor behavior in (1−x)Pb(Fe0.5Nb0.5)O3–xBiFeO3
Authors: Prah Uroš , Dragomir Mirela , Rojac Tadej , Benčan Andreja , Broughton Rachel , Chung Ching-Chang , Jones Jacob L. , Sherbondy Rachel , Brennecka Geoff , Uršič Hana
Published: February 2020

A systematic study of (1−x)Pb(Fe0.5Nb0.5)O3–xBiFeO3 (x = 0–0.5) was performed in order to investigate the strengthening of the relaxor properties when adding BiFeO3 into Pb(Fe0.5Nb0.5)O3 and forming a solid solution.
Triarylboron-based TADF emitters with perfluoro substituents: high-efficiency OLEDs with a power efficiency over 100 lm W−1
Authors: Kumar Ajay , Lee Woochan , Lee Taehwan , Jung Jaehoon , Yoo Seunghyup , Lee Min Hyung
Published: February 2020

Triarylboron emitters with secondary perfluoro acceptors display strong thermally activated delayed fluorescence (TADF) with high PLQYs up to 100%. TADF-OLEDs with the emitters achieve a high EQE of 29.9%, as well as an ultrahigh PE of 123.9 lm W−1.
A sensitive method for the quantification of short-chain fatty acids by benzyl chloroformate derivatization combined with GC-MS
Authors: Li Menghan , Zhu Rongrong , Song Xiaoxia , Wang Zhijun , Weng Hongbo , Liang Jianying
Published: February 2020

Short-chain fatty acids (SCFAs) were identified as critical markers in the diagnosis of chronic and metabolic diseases, but a sensitive and stable method to determine SCFAs in feces is a challenge for analysts due to the high volatility.
A noble-metal-free MoS2 nanosheet-coupled MAPbI3 photocatalyst for efficient and stable visible-light-driven hydrogen evolution
Authors: Wang Fang , Liu Xiangyu , Zhang Zhengguo , Min Shixiong
Published: February 2020

MoS2 nanosheets (MoS2 NSs) as a cocatalyst in situ coupled with MAPbI3 lead to a superior composite photocatalyst for visible light H2 evolution from HI splitting.
Few-layer hexagonal bismuth telluride (Bi2Te3) nanoplates with high-performance UV-Vis photodetection
Authors: Zhang Ye , You Qi , Huang Weichun , Hu Lanping , Ju Jianfeng , Ge Yanqi , Zhang Han
Published: February 2020

Topological insulator bismuth telluride (Bi2Te3) nanoplates have been employed to remarkably improve photoelectrochemical performance.
Construction of a vertically arrayed three-dimensional composite structure as a high coloration efficiency electrochromic film
Authors: Qu Xiaoshu , Ma Chao , Fu Yu , Liu Shuping , Wang Jie , Yang Yanyan
Published: February 2020

An electrochromic film with a high coloration efficiency is designed and fabricated by electrochemically depositing polyoxometalates on vertically aligned TiO2 nanowires.
Efficient synthesis of Pt–Co nanowires as cathode catalysts for proton exchange membrane fuel cells
Authors: Liu Zhikun , Yin Yanhong , Yang Daijun , Zhang Cunman , Ming Pingwen , Li Bing , Yang Shuting
Published: February 2020

A simple and efficient method was used to prepare highly active and durable carbon-supported ultrathin Pt–Co nanowires (NWs) as oxygen reduction reaction (ORR) catalysts for the cathode in a proton exchange membrane fuel cell (PEMFC).
Engineering base-excised aptamers for highly specific recognition of adenosine
Authors: Li Yuqing , Liu Biwu , Huang Zhicheng , Liu Juewen
Published: February 2020

The DNA aptamer for adenosine and ATP has been used as a model system for developing analytical biosensors.
A cascade surface immobilization strategy to access high-density and closely distanced atomic Pt sites for enhancing alkaline hydrogen evolution reaction
Authors: Liu Wenping , Ji Jing , Yan Xuecheng , Liu Wenbo , Huang Yu-Cheng , Wang Kang , Jin Peng , Yao Xiangdong , Jiang Jianzhuang
Published: February 2020

A stepwise anchoring synthetic strategy has been developed for the closely-distanced atomic Pt catalysts with superior alkaline HER activity, providing a versatile platform for accessing atomic metal catalysts toward various industrial reactions.
3D hollow-out TiO2 nanowire cluster/GOx as an ultrasensitive photoelectrochemical glucose biosensor
Authors: Yang Wenke , Wang Xiaohong , Hao Wanjun , Wu Qiang , Peng Juan , Tu Jinchun , Cao Yang
Published: February 2020

A reticulate TiO2 nanowire cluster electrode demonstrated higher sensitivity performance due to enhanced diffusion effect and more number of active sites.
Treatment of reactive arthritis with biological agents: a review
Authors: Zeng Huiqiong , Luo Baiwei , Zhang Yue , Xie Zhongyu , Ye Zhizhong
Published: February 2020

The pathogenesis of reactive arthritis (ReA) has not been fully elucidated. In recent years, many researchers have confirmed that multiple cytokines are involved in the occurrence and development of ReA. Although ReA is self-limiting, it is still incurable for some patients who have no or a weak response to traditional drugs, such as non-steroidal anti-inflammatory agents, glucocorticoids and immunosuppressive agents. This is called refractory reactive arthritis. Currently, there is insufficient evidences for the treatment of refractory ReA with biological agents, though biological agents against cytokines have been developed over the past few years. This review summarizes the current development of clinical treatments of ReA with biological agents, which provides future investigations on refractory ReA with more evidence and references.
Isorhamnetin inhibited the proliferation and metastasis of androgen-independent prostate cancer cells by targeting the mitochondrion-dependent intrinsic apoptotic and PI3K/Akt/mTOR pathway
Authors: Cai Fangzhen , Zhang Yanmei , Li Jianwei , Huang Sihuai , Gao Ruilin
Published: February 2020

The present study investigated the effects of Isorhamnetin on two types of prostate cancer cells (androgen-independent and androgen-dependent) and explored its possible mechanisms underlying such effects. Treatment with Isorhamnetin significantly inhibited cell growth and induced lactate dehydrogenase (LDH) release of androgen-independent DU145 and PC3 prostate cancer cells, but exhibited almost no toxicity effect on androgen-dependent LNCaP prostate cancer cell line or normal human prostate epithelial PrEC cells, which was achieved by the induction of apoptosis in a mitochondrion-dependent intrinsic apoptotic pathway. Furthermore, Isorhamnetin inhibited cell migration and invasion in concentration-dependent manners by enhancing mesenchymal−epithelial transition (MET) and inhibiting matrix metalloproteinase (MMP) 2 (MMP-2) and MMP-9 overexpression. In addition, Isorhamnetin also down-regulated the expression of phosphorylated PI3K (p-P13K), Akt (p-Akt), and mTOR (p-mTOR) proteins in both cancer cells, revealing Isorhamnetin to be a selective PI3K–Akt–mTOR pathway inhibitor. In summary, these findings propose that Isorhamnetin might be a novel therapeutic candidate for the treatment of androgen-independent prostate cancer.
HSPA1L rs1061581 polymorphism is associated with the risk of preeclampsia in Han Chinese women
Authors: Zong Jinbao , Lin Yan , Tian Qingwu , Zhao Xin , Chu Kaiqiu , Jiang Bing , Li Shengjun , Sun Guirong , Liu Shiguo
Published: February 2020

Preeclampsia (PE) is an excessive systemic inflammation response with dysfunction of endothelial. As a stress protein, heat shock protein 70 (HSP70) plays a pivotal role in protecting cells against apoptosis, oxidative damage and genetic damage. In humans, three genes encode members of the HSP70 class: HSPA1A, HSPA1B and HSPA1L. Our study was to investigate the association between genetic variations of HSPA1L and the susceptibility for PE in Chinese Han population. The polymorphisms of rs2227956, rs1043618 and rs1061581 in HSPA1L were genotyped by TaqMan allelic discrimination real time polymerase chain reaction (PCR) in 929 PE patients and 1024 healthy pregnant women. Statistic difference of the genotypic and allelic frequencies were found in HSPA1L rs1061581 between PE patients and controls (χ2 = 29.863, P < 0.001 by genotype; χ2 = 27.298, P < 0.001, OR = 1.874, 95%CI 1.476–2.379 by allele) and HSPA1L rs1061581 A alleles occurred more frequently in PE patients compared with healthy controls (PE vs. controls 10.28% vs. 5.76%). Furthermore, we divided the PE cases into early-onset/late-onset PE and mild/severe PE subgroups and found statistical differences in genotypic and allelic frequencies of the HSPA1L rs1061581 between early-onset PE, late-onset PE, mild PE, severe PE and controls, respectively. Moreover, HSPA1L rs1061581 A alleles were more frequent in early-onset PE, late-onset PE, mild PE and severe PE than controls respectively. Therefore, we concluded that HSPA1L rs1061581 polymorphism is associated with the risk of PE in Han Chinese women and A alleles may play a role in the susceptibility for PE.
Clusterin role in hepatocellular carcinoma patients treated with oxaliplatin
Authors: Wang Xiumei , Liu Yongqiang , Qin Qiong , Zheng Ti
Published: February 2020

Aim: To explore the prognostic value of clusterin (CLU) in hepatocellular carcinoma (HCC) patients treated with oxaliplatin (OXA).

Methods: Relative expression of plasma CLU mRNA was examined via fluorescence quantitative real-time PCR (qRT-PCR), and CLU protein level in tissue samples was detected through immunohistochemistry. Chi-square test was used to analyze the relationship between CLU mRNA expression and clinical features of HCC patients treated with OXA. Kaplan–Meier method was performed to assess overall survival for the patients, and prognostic value of CLU in HCC patients was estimated via Cox regression analysis.

Results: CLU expression in plasma and tissue specimens was significantly higher among HCC patients than in non-malignant controls (P < 0.001 for both). Moreover, elevated CLU mRNA was closely related to tumor stage, lymph node metastasis and response to OXA (P < 0.05). HCC patients with high CLU expression showed poor response to OXA. In addition, low CLU levels predicted long overall survival time among the study subjects (20.8 vs. 36.6 months, P < 0.001). CLU was an independent prognostic indicator for HCC patients treated with OXA (HR = 2.587, 95%CI = 1.749–3.828, P < 0.001).

Conclusion: CLU may be a novel prognostic marker for HCC patients treated with OXA.
Crystallization of the inner crust of a neutron star and the influence of shell effects
Authors: Carreau T. , Gulminelli F. , Chamel N. , Fantina A. F. , Pearson J. M.
Published: February 2020

Context. In the cooling process of a non-accreting neutron star, the composition and properties of the crust are thought to be fixed at the finite temperature where nuclear reactions fall out of equilibrium. A lower estimate for this temperature is given by the crystallization temperature, which can be as high as ≈7 × 109 K in the inner crust, potentially leading to sizeable differences with respect to the simplifying cold-catalyzed matter hypothesis.

Aims. We extend a recent work on the outer crust to the study of the crystallization of the inner crust and the associated composition in the one-component plasma approximation.

Methods. The finite temperature variational equations for non-uniform matter in both the liquid and the solid phases are solved using a compressible liquid-drop approach with parameters optimized on four different microscopic models that cover current uncertainties in nuclear modeling.

Results. We consider the effect of the different nuclear ingredients with their associated uncertainties separately: the nuclear equation of state, the surface properties in the presence of a uniform gas of dripped neutrons, and the proton shell effects arising from the ion single-particle structure. Our results suggest that the highest source of model dependence comes from the smooth part of the nuclear functional.

Conclusions. We show that shell effects play an important role at the lowest densities close to the outer crust, but the most important physical ingredient to be settled for a quantitative prediction of the inner crust properties is the surface tension at extreme isospin values.
Development of a method for determining the location of a single line-to-ground fault of an overhead power line with voltage of 6(10) kV considering climatic factors
Authors: Sidorov Sergey , Sushkov Valery , Sukhachev Ilya
Published: February 2020

One of the main causes of the high accidents and outages rate in 6(10)-kV distributed power supply systems of oil well clusters is damage to overhead power lines due to single line-to-ground faults. Widely conducted studies to locate a single line-to-ground fault have established a correlation between the accuracy of determination and a large number of changing factors, such as operating mode parameters, overhead power line parameters, type of damage, transition resistance, soil resistance, and others. Rationing of technical means for determining the location of a single line-to-ground fault by instrumental errors without taking into account the methodological component translates into the error in locating the damage up to 30%. Thus, relevant research is aimed at determining the primary parameters of power lines and minimizing the methodological error in determining the location of damaged power lines, considering climatic factors. The study takes into account the basic physical processes of propagation of an electromagnetic wave in the power line. The main principles of the theory of electrical circuits and the electromagnetic field and MATLAB Simulink package algorithms are used. As part of the study, a technique has been developed that allows determining the distance from 6(10)/0.4-kV substations to a single line-to-ground fault location in distribution networks of oil well clusters taking into account climatic factors. A simulation model of a 10-kV distribution network supplying oil well clusters was developed in MATLAB Simulink, taking into account the dependence of the primary power line parameters on climatic factors and soil resistivity.
Economic prerequisites for the development of low-energy based on the development of unclaimed hydrocarbon deposits
Authors: Melekhin E.S. , Pelmeneva A.A. , Kuzina E.S.
Published: February 2020

The article assesses the state of the mineral resource base of hydrocarbon raw materials, provides estimates of the commercial efficiency of hydrocarbon field development, examines and substantiates the main economic prerequisites for the development of distributed generation based on the development of unclaimed small hydrocarbon fields.
Moisture content as an important integral parameter of transformer oil quality in power transformers of 10/0.4 kV substations
Authors: Trushkin V , Shlyupikov S , Eroshenko G , Levin M , Kifarak S
Published: February 2020

The main element characterizing the transformer efficiency is the state of its isolation, and the first thing is operating oil, which can perform its functions for a long time with timely restoration of its properties. Transformer oil is the main dielectric being in contact with the external environment, interacting with solid insulation and carrying a large amount of diagnostic information. Analysis of the development of transformer insulation damage showed that the main catalyst for accelerating the aging process of the oil is the appearance of moisture in it. This effect is enhanced by oxygen, temperature, the catalytic action of metals, oxidation and other factors. To confirm the influence of moisture content in oil on the deterioration of its properties, a statistical analysis of the oil sample test protocols was carried out. The obtained data allowed us to determine the moisture content as an important integral parameter of oil quality. Recommendations are given on the inclusion of a moisture content parameter in a set of mandatory requirements, in particular, for 10/0.4 kV consumer transformer substations equipped with silica gel air dryers
Measuring complex for examination the combustion products’ composition and the soot particulate sol microstructure
Authors: Moskalenko N.I. , Dodov I.R. , Khamidullina M.S. , Safiullina Ya.S.
Published: February 2020

A measuring complex of spectral instrumentation for examination of the ingredient composition, optical characteristics and microstructure of the dispersed phase of the combustion products of energy fuels and atmospheric anthropogenic emissions is discussed. The measuring complex includes a multi-pass cell with external and internal electric heating, which makes it possible to change the temperature of the radiation propagation medium in a multi-pass cell in the temperature range of 300–800 K, in the pressure range of 1*102 ≤ P ≤ 3*106 Pa with optical path L = 2, 4, 6, ... 30 m. Registration of spectra is performed by an upgraded spectrometer IKS-31 with interchangeable sources and radiation receivers, interchangeable diffraction gratings and cut-off light filters, interchangeable quartz windows, CaF2, LiF, MgF2, IKS-25, KRS-5, ensuring their operation in the spectral region of 0.2–100 μm with the spectral resolution limit Δν = 0.2 cm-1. The measuring complex has a complete metrological assurance. The obtained data on the spectral dependences of the effective cross sections for absorption, scattering, and attenuation of radiation are used to restore the microstructure of the dispersed phase of the combustion products. The atmospheric emissions of combustion products of wood, industrial energy, air carriers, decomposition products of asbestos-cement slabs during their calcinations were analyzed.
Calculation of the electrodynamic forces causing deformation of the power transformer’s windings
Authors: Khrennikov A Yu , Aleksandrov N.M.
Published: February 2020

This paper describes modified method to calculate electrodynamic forces causing deformation of the power transformer’s windings. This method takes into account the deformed shape of the winding. The new equations allow to get better accuracy.
The main indicators of choosing the scheme of providing hot water supply in cities
Authors: Gazizov F , Ahmetova I.
Published: February 2020

In the article the basic indicators defining the choice of this or that scheme of the organization of the closed hot water supply of the cities (further – HWS) using open schemes of HWS are considered. Block diagrams of boundary conditions and independent variables are presented. A pyramid of conditions affecting the level of capital and annual costs for the maintenance of heat supply systems for the useful life (25 years) of the equipment is proposed. The main provisions of the method and the program of choosing the most appropriate scheme of transition to the closed circuit of preparation of hot water with the calculation of weight coefficients are formulated.
Methodology for assessing the economic efficiency of investment projects in petrochemical companies
Authors: Bondarenko Tatiana , Bolvachev Aleksei
Published: February 2020

The article focuses on the issues of investment potential of petrochemical companies and the need to develop a unified approach transparent for all the participants, to assess the efficiency of investment projects in petrochemical companies. The proposed methodology is to be applied to scheduling project costs and in fact, to ground the establishment of annual financing limits for a project. Additionally, the methodology is expected to reflect the possibility of updating the main indicators, both for financing the purchase of domestic and imported equipment. The methodology also takes into account the mechanism of contract pricing, recalculation of the cost of works and services is performed according to the rules and regulations approved for the estimates in any petrochemical company, inclusive of the indices of changes in current estimated cost to base period prices. The proposed methodology for assessing the performance indicators of investment projects is one of the most multi-faceted and optimal tools for petrochemical companies for attracting additional funding from both their own and other sources. In the conditions of growing business volumes, and in case of complying with the recommendations of the state strategy for the industry growth until 2030, the proposed methodology is transparent and relevant to all the investment participants in terms of cash flow generation for the project.
Identification of areas of emergence of critical flow regimes of nonlinear viscous liquids in a tubular reactor
Authors: Livshits S.A. , Yudina N.A. , Dunaeva T.U. , Nikolaeva E.K. , Enikeeva S.R.
Published: February 2020

The mathematical model describing heat-mass transfer in rheologically complex media in a tubular reactor is developed in the article. Using the example of the continuous production scheme for grade B2 polymethacrylate, solutions of the characteristic equations confirming the possibility of emergence the critical flow regimes for certain sets of control parameters were obtained.
Energy efficiency of improvement of agriculture optimization technology and machine complex optimization
Authors: Apazhev A.K. , Fiapshev A.G. , Shekikhachev Iu.A. , Khazhmetov L.M. , Khazhmetova A.L. , Ashabokov Kh Kh
Published: February 2020

To ensure the food security of the Russian Federation, one of the priority areas of the state’s economic and food policy is a step-by-step reduction of the dependence of the domestic agroindustry complex on the import of technologies, machines, and equipment. Currently, machines and aggregates that perform one specific operation are often used in preparing the soil for sowing crops; their multiple passes along the surface of the field being treated increase energy costs, lead to soil compaction, emergence and development of erosion processes. Considering this, further improvement of cultivation technologies, machines and units for soil preparation and sowing crops is required. To solve this problem, we propose an improved technology and an optimized complex of machines that can perform plowing, crushing soil blocks, mulching the topsoil, and sowing. The use of the proposed technology and an optimized machinery complex for the cultivation of winter wheat in the Central part of the North Caucasus resulted in a decrease in: direct energy costs by 33.5%; living labor costs by 31.7%; specific energy consumption of MTA by 41.7%; materialized energy costs by 50%; energy consumption for sowing by 7.7%. As a result, total energy costs decreased by 34%.
Ensuring efficient operation of electromechanical systems with frequency regulation with periodic voltage sags
Authors: Bialy W , Sovin V.E. , Zatsepina V.I. , Zatsepin E.P. , Shachnev O Ya
Published: February 2020

The article reflects influence of high-power electricity consumers on control elements of frequency control of electric drive. Solution of problem of eliminating influence of voltage dips on electromechanical systems by means of a modern method of reactive power compensation is presented. Graphs of power, current, voltage versus time are presented, graphs of voltage curve are analyzed in detail with proposal of method of its normalization.
Relationship between the technical condition of the equipment of heat and power engineering units and the noise level in the environment
Authors: Gorbunova O.A. , Pavlov G.I. , Nakoryakov P.V. , Khakimzyanova Yu.I.
Published: February 2020

The problem of environmental noise pollution from large-city centralized heating systems is considered. Based on the analysis of acoustic characteristics and vibration parameters of district boiler house power plants, the main reasons for the generation of increased noise are identified. The relationship between the technical condition of the power equipment, buildings, structures and the noise level in the environment is revealed. The possibility of developing complexes of technical measures to reduce noise pollution adjacent to the district boiler houses of the city is shown. While optimizing the selected variants of noise and vibration dampening complexes, it seems promising to use a calculated model of the noise field.
Determination of the sediment thickness on the heat-exchange surfaces by free vibration method
Authors: Izmaylova E.V. , Garnyishova E.V. , Kazakov R.B. , Serov V.V.
Published: February 2020

Sediments on the heat exchangers surfaces reduce the heat transfer coefficient and heat exchange efficiency, and lead to significant energy losses. The paper discusses the method of express control of the sediment thickness on heat-exchange surfaces. The method is based on the analysis of attenuation of free oscillations parameters of the controlled product. Studies were conducted on models of the heat-exchange equipment surface, namely steel plates of 400 mm long, 160 mm wide and 2 mm thick, with different sediments thicknesses of 0, 1.0, 1.5, 2.0, 2.5 mm. The Wilcoxon’s rank sum test was used to determine the dynamics of the spectra changes. Studies have shown that the free vibration method allows one to determine not only the presence of deposits on the heat-exchange surfaces, but also their thicknesses.
Methods of Conditioning Sustainable Growth Programs of Power Generating Companies
Authors: Garnov A.P. , Bykova O.N. , Repnikova V.M.
Published: February 2020

Purpose: to propose a program for the sustainable development of production complexes of the electric power industry, a distinctive feature that will be to increase production efficiency and preserve the environment.Findings: after conducting a scientific study, the authors obtained indicators for analyzing the effectiveness of the program, which were tested on the example of two territorial generating companies located in Buryatia and the Trans-Baikal Territory.Results: the proposed and tested program contains a number of advantages related to energy efficiency, preserving the environment, increasing the reliability and uninterrupted power supply.Value: the proposed program of the sustainable growth of power generating companies considering the adjustment of the production characteristics, the use of energy resources and the existing infrastructure, can become the basis for the power companies.
Computer modeling of the wind power unit constructions with power over 2 MW
Authors: Strelkov U.M. , Radaykin O.V. , Sabitov L.S. , Akhmerov A.V.
Published: February 2020

The aim of this work is to evaluate the efficiency of the system “steel tower reinforced concrete foundation – foundation ground” of a wind power unit with power more than 2 MW using computer simulation in ANSYS. For this purpose, an example of a wind power unit is taken from the previous work, but in this case the lower part of the tower up to height of 20 m was filled with B60 concrete. The second distinctive feature of the presented wind power unit is the use of a collapsible foundation, which was manufactured according to our patent. The simulation takes into account the spatial reaction of elements of the structural system and the physical nonlinearity of the materials from which they are made. In this case, for steel the von Mises theory of strength was used, for concrete the Williams-Varnack theory was used, and for ground base the Drucker-Prager theory was used. Comparison of the obtained results with data of previous work showed that the breaking load of tower has increased by 57% due to filling the lower part of the tower by concrete, which indicates the efficiency of the proposed solutions.
Management of loyalty in developing a company’s brand on the Russian oil and gas B2B market
Authors: Puzina N.V. , Vereteno A.A. , Luneva E.A. , Katunina N.V.
Published: February 2020

In this article, we consider the importance of lifestyle and preferences of the decision-makers as parts of management of loyalty in developing a company’s brand on the Russian oil and gas B2B market. We provide the definitions of the concepts of “brand” and “loyalty”, types of loyalty and development stages of a loyalty program. Additionally, we report the results of a marketing research for development of the loyalty program of the oil trading company (characteristics, opinions and preferences of the decisionmakers on the Russian market of light oil and liquefied hydrocarbon gas products).
Arguments for tightness testing of nuclear system pipeline parts, attached to pressureless tanks
Authors: Ivanov A.I. , Kritchenkov A.S. , Egorov M Yu
Published: February 2020

Actual standard, namely Rules for design and safe operation of equipment and pipelines of nuclear power installations (2015) does not regulate strength and tightness testing of pipeline parts, located between valves and pressureless tanks of nuclear systems at nuclear power plants. This paper introduces arguments for strength and tightness test conduction of such areas of nuclear power plant pipelines, designed in accordance with Russian standards. It was also proposed some amendments for the norm aimed to improve safety and reliability of nuclear power plant systems with radioactive contamination. It was suggested to apply the result of current study to Leningradskaya-2 in order to improve safety and decrease the number of failures of the liquid radioactive waste storage system.