bluuebunny/crossref_metadata_2025 huggingface dataset:
I.F. Bush surgical scientific school
Authors: Ivanusa Sergey Y. , Kosachev Ivan D. , Dzhachvadze David K.
Published: October 2023

The study presents the main milestones in the history of the surgical scientific school of I.F. Bush, the founder and first head of the Department of Theoretical and Practical Surgery of the Medical Surgical Academy, who led it from 1800 to 1833. Being the head of one of the first departments of the academy, I.F. Bush can rightfully be considered the founder of the pedagogical school. The Guide to Teaching Surgery, which he published in 1807, became the first textbook in the specialty in Russian, which was taught for 40 years. The textbook also contained sections devoted to narrow surgical specialtiesdesmurgy and mechanurgy, thermal lesions, otorhinolaryngology, ophthalmology, maxillofacial surgery and dentistry, gynecology, urology, skin, and venereal diseases; accordingly, I.F. Bush can be considered the founder of these academic disciplines in our country. During the period of his leadership of the department, I.F. Bush had trained 15 professors who had led many of the nations surgical teams, as well as more than 2000 practicing surgeons. Many university and professional communities have chosen I.F. Bush as an honorary member. In Saint Petersburg and Moscow, the Bush Prizes were established for distinguished students. The first scientific academic schools served as the bases for the formation of subsequent scientific directions in surgery under the guidance of N.I. Pirogov, N.V. Sklifosovsky, S.P. Fedorov, V.N. Shamov, S.S. Lytkin, P.N. Zubarev, and others. The scientific school created by I.F. Bush was a Russian school, different from Western surgical schools in its basis, style, and organization of teaching. He put forward a galaxy of major surgical scientists who glorified Russian science. Representatives of this school have done important research in the field of surgery, anatomy, forensic medicine, eye diseases, gynecology, epidemiology, oncology, transfusiology, etc. Their works were translated into foreign languages, and many of them became classics. As clinicians, representatives of the first surgical scientific school were in no way inferior to the best surgeons in Europe. The article contains historical, practical, and professional interests for a wide range of readers: surgeons, historians of medicine and science, and general practitioners who are not indifferent to the history of domestic surgery.
Features of the course of traumatic shock when using respiratory mixtures with a high content of inert gases
Authors: Nosov Artem M. , Petrov Vasiliy A. , Demchenko Konstantin N. , Morgunov Nikolay A. , Lakhin Roman E. , Zhirnova Natalya A. , Kolvzan Stanislav P.
Published: October 2023

This study evaluated the efficiency of using gas mixtures with increased concentrations of inert gases on a hemorrhagic shock model in experimental animals. Massive blood loss is considered a trigger mechanism of severe pathophysiological reactions (impaired peripheral perfusion, acidosis, hemostasis system dysfunction, and multiple organ failure). Inert gases (helium, argon, and xenon) attract attention as potentially useful in various pathological conditions. The study was conducted on 15 same-sex pigs of the same breed, weighing 40–50 kg, randomized into three groups with five each: control group, inhalation of 100% oxygen; “agohhep” group, inhalation of the “Aroxxen” gas mixture: 35% argon, 58% oxygen, 0.2% xenon, and nitrogen as the rest of the volume; and “agohhep-krypto” group, inhalation of the gas mixture “Aroxxen-krypto”: 35% argon, 40% oxygen, 10% krypton, and nitrogen as the rest of the volume. Dynamic monitoring of vital signs and sampling of materials were conducted before blood loss, with blood loss of 20% and 45% of the volume of the circulating blood 60, 120, and 180 min after blood loss. The survival rate of animals and respiratory and circulatory states were evaluated by clinical and laboratory indicators. With blood loss of 45% of the circulating blood volume, no statistically significant differences in mortality were found between the groups. All animals survived for 180 min in the post-hemorrhagic period. In the aggohep-krypto group, average blood pressure values after blood loss and throughout the follow-up period were significantly higher than those in the control and aggohep groups (p 0.05). During shock simulation as a result of blood loss, base deficiency gradually worsened in all groups. However, starting from the second hour of observation, base deficiency began to be compensated in the control and aggohep-krypto groups and the aggohep group, it continued to increase significantly (p 0.01). During the follow-up after blood loss, the level of lactatemia significantly increased in the aggohep group (by 10 times at the end of the follow-up), which is significant different from those in the control and aggohep-krypto groups (p 0.01). Thus, compared with the use of Arroxen gas, the use of Arroxen-krypto gas of the proposed composition in acute massive blood loss makes it possible to achieve a less pronounced attrition of the acid–base balance in experimental animals.
The problem of spatial disorientation and professional selection of flight personnel
Authors: Blaginin Andrey A. , Lyashedko Semen P.
Published: October 2023

The study analyzed the results of an experimental study on the influence of optokinetic, statokinetic, and combined optostatokinetic types on the spatial orientation of aviation profile operators. Three series of experiments were conducted, with the participation of 32 men aged 2223 years, who had previously been assessed for vestibular stability using the intermittent cumulation of Coriolis accelerations. In the first series, the statokinetic effect was analyzed by performing a vestibular test Otolith reaction-10 on an electric rotating chair Nydiag. In the second series, the condition of being inside an optokinetic drum was imitated, for which virtual reality glasses VRBoxVR 2.0 were used. In the third series, the combined staticoptokinetic effect was analyzed. If all the participants took part in the first two series, then only 27 people took part in the third because five participants, who experienced a significant deterioration in well-being and exhibited pronounced vegetative reactions after combined stato-optokinetic exposure, could not complete the vestibular test on an aviation simulator in full and were forced to refuse further participation. The combined optostatokinetic effect has the most pronounced negative effect on the quality of spatial orientation, in which the generalized piloting error and the time of bringing the aircraft simulator to the specified parameters were greatly affected than with isolated types of exposure. Thus, the assessment of only statokinetic stability does not allow us to fully assess high-quality aerobatic ability with high indicators of qualitative characteristics of spatial orientation. Moreover, the quality of a pilots spatial orientation is one of the most important parameters of piloting, which directly affects flight safety. However, only the degree of vestibular stability is assessed in the initial selection to educational institutions for the training of flight personnel, without predicting the effect of this characteristic on the quality of spatial orientation. Considering these results, at the stage of medical selection to higher educational institutions for the training of flight personnel, we propose evaluating not only isolated statokinetic resistance but also resistance to combined optostatokinetic effects.
Effectiveness of intraoperative monitoring of the bulbocavernosus reflex for predicting postoperative pelvic disorders in the surgical treatment of distal spine tumors
Authors: Malyshok Dar’ya Е. , Bisaga Gennadiy N. , Оrlov Аndrei Y. , Oleynik Ekaterina A. , Tsygan Nikolai V. , Aleksandrov Mikhail V.
Published: October 2023

The study evaluated the diagnostic effectiveness of changes in the parameters of the bulbocavernous reflex during intraoperative neurophysiological monitoring in the surgical treatment of caudal spinal cord tumors. The study was performed during examinations and neurosurgical treatment of 58 patients suffering from intradural extramedullary and intramedullary tumors of the caudal spinal cord. In 23 (39.7%) patients, the tumors were localized at the level of the lower thoraciclumbar spine (Th11L1), and in 35 (60.3%) patients, they were at the level of the lumbosacral spine (L2S2). Pelvic organ dysfunction was assessed based on the extent of neurogenic bladder symptoms before surgery, 1014 days after surgery, and a year later. The bulbocavernous reflex was recorded in response to genital nerve stimulation, with a series of three pulses lasting 0.5 ms each, and the repetition rate of the series was 2 Hz. The intensity of the stimulation current was 75% of the maximum intensity. The bulbocavernous reflex was registered from the external anal sphincter muscles. During intraoperative monitoring, the bulbocavernous reflex remained stable in 49 patients. In this group, pelvic dysfunction was not observed immediately or 12 months after surgery. Persistent changes in motor response parameters were registered in nine patients; seven and eight cases of dysuric disorders were observed immediately after surgery and 12 months after surgery, respectively. Persistent changes in the bulbocavernous reflex during intraoperative monitoring were significantly more often associated with pelvic organ dysfunction immediately after surgery (2 = 36,323; p 0.001) and 12 months after surgery (2 = 32,284; p 0.001). The sensitivity and specificity of intraoperative monitoring of the bulbocavernous reflex in assessing the risk of pelvic dysfunction in the postoperative period were 96.1% and 100%, respectively. In general, postoperative pelvic organ dysfunction is a frequent cause of neurological complications following surgical treatment of caudal spine tumors. Therefore, during surgery, neurophysiological monitoring is implemented to control pelvic organ functions, including the registration of the bulbocavernous reflex.
Changes in the cerebral cortex and thyroid in the simulation of cerebral hypoperfusion and its combination with physical exercise
Authors: Gaivoronskii Ivan V. , Chrishtop Vladimir V. , Nikonorova Varvara G. , Semenov Aleksei A.
Published: October 2023

Cerebral hypoperfusion, as the main mechanism of age-associated diseases, is widespread, which leads to decreased work capacity in the most qualified segment of employees. The study aimed to analyze compensatory and adaptive reactions of the cerebral cortex, thyroid gland, and blood in cerebral hypoperfusion and its combination with short-term physical activity. Chronic cerebral hypoperfusion was modeled by permanent bilateral occlusion of the common carotid arteries. The study included 280 rats, of which 112 were subjected to daily short-term swimming as a model of rehabilitation measures. On days 1, 6, 8, 14, 21, 28, 35, 60, and 90 after surgery, the animals were subjected to the Morris water maze and open field tests. Histological sections of the brain and thyroid gland were examined. The concentrations of the active products of thiobarbituric acid, nitrites, and L-arginine in blood plasma were measured. The results showed that changes in the cerebral cortex and thyroid gland in the cerebral hypoperfusion model were characterized by a general stage: days 18, hypothyroid condition and death of cortical cells, cerebral hemispheres, predominantly neurons; weeks 23, stabilization, transition to the euthyroid condition, accompanied with thyrocyte desquamation, folliculogenesis, perifollicular hemocapillaries fullness, decreased functional activity of neurons, and astrocyte activation; weeks 45, incomplete adaptation, which is characterized by neurons approaching the vessels of the hemocirculatory channel and satellites sinking into the cytoplasm of neurons. Mosaicism of thyroid blood filling was also observed. After 3 months, degenerative changes in the cells of the cerebral cortex of the cerebral hemispheres appear, including a decrease in the numerical density of neurons and immunoreactive cells of glial fibrillar acid protein and a hyperthyroid state with signs of decompensation: plasmorrhagia and desquamation of the thyroid epithelium. Daily 15-min exercise with cerebral hypoperfusion demonstrated a neuroprotective effect, slowed down the progression of hypoxic and neurodegenerative changes, and reduced the concentration of nitrites and malondialdehyde in the blood and the levels of neuronal nitric oxide synthase in immunoreactive neurons.
Features of cognitive impairment in patients with thyroid dysfunction
Authors: Romashevsky Boris V. , Salukhov Vladimir V. , Maxim Oksana V.
Published: October 2023

The study presents research results on the effect of thyroid hormones on cognitive function in patients with thyroid diseases. The study highlighted the mechanisms of the development of cognitive disorders in these patients, which include altered neurotransmission processes and expression of genes responsible for the proliferation of neurons and glial cells, bloodbrain barrier dysfunction, decreased plasticity of neurons, and damage to brain tissue repair systems, which allows for identifying new therapeutic strategies for the treatment of cognitive disorders. Thyroid metabolism disorders are manifested by numerous symptoms, including those associated with cognitive deficits. Thus, the true cause of the disease must be identified, since the correction of thyroid hormone levels will lead to symptom regression, whereas symptomatic treatment is not always effective and may worsen the course of the underlying disease. In patients from different age groups, thyroid dysfunction is one of the causes of cognitive impairment. Cognitive decline, dysphoria, and depression are the most common in hypothyroidism, and thyrotoxicosis is accompanied by symptoms of arousal, mood lability, psychosis, and apathy. Cognitive impairment negatively affects the quality of life of patients, worsens treatment adherence, and can promote the development of acute and chronic complications associated with thyroid diseases. An equally important problem is the insufficiency of objective criteria for the verification of cognitive impairment and the lack of effective treatment methods and consequently the late and ineffective implementation of therapeutic measures. In general, thyroid dysfunction is accompanied by various neurocognitive disorders, and severity depends on sex and the etiology, duration, and severity of the disease. Correction of thyroid metabolism disorders does not always eliminate cognitive impairments; therefore, a multidisciplinary approach is needed, with the participation of not only endocrinologists but also specialists in neuropsychiatric profile. Further research on the pathogenesis of cognitive disorders in thyroid dysfunction will allow for identifying new therapeutic strategies aimed at early detection and correction of cognitive deficits, reducing the risk of neurodegenerative processes, and ultimately will reduce the treatment and rehabilitation time.
Comparative analysis of the long-term surgical treatment results of noninvasive thymus gland tumors
Authors: Levchenko Evgeny V. , Dzidzava Ilya I. , Dmitrochenko Ivan V. , Fufaev Evgeny E. , Yasyuchenya Denis A. , Barinov Oleg V. , Popov Vladimir A. , Grishchenkov Alexander S.
Published: October 2023

The study compared the long-term results of thymectomy from traditional open thoracic/sternotomic and endovideosurgical access in 98 patients with thymus tumors. All patients were divided into two groups depending on the thymectomies performed from various surgical approaches. The control group consisted of 34 patients in whom surgical interventions were performed via the traditional open access, and the main group consisted of 29 patients in whom surgical interventions were performed via the endovideosurgical access. Both groups were comparable by sex, age, concomitant pathology, presence, and severity of clinical signs of myasthenia gravis, tumor size, morphological structure, and progression stage according to the classifications by Masaoka-Koga (1997) and TNM-8 2017. According to the frequency of tumor recurrence and regression of myasthenic disorders within 3 years after surgery, no significant differences were found between the groups (2 (5.9%) and 0, p = 0.27;
9 (69.2%) and 10 (71.4%), p = 0.52, respectively). Moreover, no significantly significant differences were found in the long-term survival (so-called KaplanMeier survival function) between the two groups. The annual, 3-, 5- and 10-year survival rates in the control group were 100%, 90.3% 2%, 87% 4%, and 87% 4%, and in the video-assisted thymectomy group, the survival rates were 100%, 100%, 100%, and 92.3% 3%, respectively (p = 0.71). In general, the long-term results of endovideosurgical thymectomy with small tumors and the absence of invasion into neighboring anatomical structures do not differ from those of traditional open surgical interventions in terms of the main oncological indicators, namely, long-term survival and frequency of tumor recurrence. The obtained results are consistent with world literature data, according to which the most significant prognostic factor of long-term survival is the stage of tumor progression by TNM. The average 5-year survival rates following radical thymectomy were 90%, 90%, 60%, and 25%, respectively, for TNM stages I, II, III, and IV.
Dynamic Rupture Models of the 2016 ML 5.8 Gyeongju, South Korea, Earthquake, Constrained by a Kinematic Rupture Model and Seismic Waveform Data
Authors: Song Seok Goo , Duan Benchun
Published: October 2023

The ML 5.8 earthquake that jolted Gyeongju in southeastern Korea in 2016 was the country’s largest inland event since instrumental seismic monitoring began in 1978. We developed dynamic rupture models of the Gyeongju event constrained by near-source ground-motion data using full 3D spontaneous dynamic rupture modeling with the slip-weakening friction law. Based on our results, we propose two simple dynamic rupture models with constant strength excess (SE) and slip-weakening distance (Dc) that produce near-source ground-motion waveforms compatible with recorded ones in the low-frequency band. Both dynamic models exhibit relatively large stress-drop values, consistent with previous estimates constrained by source spectrum analyses. The fracture energy estimates were also larger than those predicted by a scaling relationship with the seismic moment. The dynamic features constrained in this study by spontaneous rupture modeling and waveform comparison may help understand the source and ground-motion characteristics of future large events in southeastern Korea and thus the seismic hazard of the region.
Transformer Graph Convolutional Network for Relative Travel-Time Shift Prediction
Authors: Jin Chunwei , Ye Fang , Cai Jinhui , Yao Yan
Published: October 2023

Predicting surface-wave travel-time shifts is valuable for analyzing potential effects caused by changes in medium properties, station clock errors, instrument response errors, and other factors. Many current neural networks used in seismology are single-station models trained using single-station (pair) data. However, most seismic methods require knowledge of the spatial positions between multiple stations. Multiple stations contain rich interrelationships and spatial information that cannot be exploited by single-station models. We proposed a multistation neural network structure Transformer Graph Convolutional Network (TGCN) that utilizes temporal attention and spatial attention to capture spatiotemporal information for predicting relative travel-time shifts. Before that, we introduced a method that treats station pairs as nodes and constructs a graph with multiple station pairs. We collected original ambient noise waveforms from 2017 to 2019 in the Alaska region and 2010 to 2014 in the southern California region to obtain relative travel-time shift sequences of station pairs for model training and testing. To showcase the improvement of spatial information to the model, we compared TGCN with two other baseline single-station models—temporal convolutional network and long short-term memory. Our proposed method predicted travel-time values more accurately than the two baseline models, and it also exhibited slower decay in performance when predicting over larger intervals. We also found that the number of station pairs has an impact on the model. When there are a sufficient number of station pairs, the model can effectively utilize the rich spatial information and achieve higher accuracy. Our approach, which incorporates spatiotemporal information, provides outputs that are more efficient and accurate compared with the traditional single-station (pair) method that only considers temporal information, suggesting that spatial information does enhance the performance of the model.
Normal-Tension Glaucoma: Epidemiology, Pathogenesis, Diagnosis and Treatment. Review. Part 1
Authors: Kurysheva N. I. , Kim V. E. , Plieva H. M. , Kim V. Yu. , Nurmahadzhiev D. M.
Published: October 2023

In the modern world, glaucoma is one of the main causes of irreversible vision loss. Normal tension glaucoma (NTG) constitutes the major proportion of POAG, which is common in Asian populations. NTG is a disease resulted from the interaction of multiple genetic risk factors. But other factors are also important, such as thinning of the scleral lamina cribrosa and a lesion of the transmembrane pressure gradient. Central visual field defects and disc hemorrhage are characteristics finding that is highly associated with the progression of NTG.
Optical Coherence Tomography Based Differentiation of Intravitreal Particles in Posterior Uveitis and Vitreous Hemorrhage
Authors: Kalinicheva Ya. A. , Kulikov A. N. , Maltsev D. S.
Published: October 2023

Purpose: to study optical coherence tomography (OCT) characteristics of intravitreal particles in vitreous hemorrhage and posterior uveitis. Patients and methods. 29 patients with posterior uveitis (43.1 ± 19.4 years, 10 females and 19 males) and 29 patients with vitreous hemorrhage (62.3 ± 11.6 years, 9 females and 20 males) were included. All patients received standard ophthalmological examination and multimodal imaging, including OCT. The size and reflectivity of preretinal intravitreal particles was assessed on crosssectional OCT scans. Results: Intravitreal particles in eyes with posterior uveitis had a statistically significantly larger size compared to the particles in vitreous hemorrhage, 47.0 ± 29.0 and 41.3 ± 22.6 pixels, respectively (p < 0.001). At the same time, intravitreal particles in eyes with posterior uveitis had lower mean reflectivity compared with eyes with vitreous hemorrhage, 126.0 ± 10.5 and 135.2 ± 11.1, respectively (p < 0.001). The maximum reflectivity of intravitreal particles in eyes with posterior uveitis was also lower than that of particles in eyes with vitreous hemorrhage, 186.2 ± 24.9 and 166.3 ± 23.7, respectively (p < 0.001). Conclusion. Intravitreal particles displayed with OCT in posterior uveitis are less reflective and larger than those in vitreous hemorrhage.
Additive Therapy for Advanced Stages of Glaucoma
Authors: Gazizova I. R. , Korelina V. E. , Goncharuk E. P.
Published: October 2023

Purpose of the study: to evaluate the efficacy and feasibility of using brimonidine 0.2 % in the additive therapy of patients with advanced stages of glaucoma. Materials and methods. There were 59 patients (77 eyes) with advanced stages of primary open-angle, glaucoma (POAG) aged 68 to 83 years in the study. Patients were randomized into 2 groups depending on the received antihypertensive therapy. The first group (I) included 32 people (41 eyes) who used a fixed combination of a prostaglandin analogue (APG) or a carbonic anhydrase inhibitor (CAI) with a beta-blocker (BB) for the treatment of POAG. The second group (II) consisted of 27 patients (36 eyes) who had the α2-adrenergic agonist brimonidine — S3 added to the previously available combination of APG or ICA with BB. The observation period was 6 months. Results. Application of brimonidine — SZ in the additive therapy of advanced stages of glaucoma led to an additional hypotensive effect. By the end of the observation period in the group of patients treated with brimonidine, intraocular pressure decreased by an additional 10 % from the initial level. A good hypotensive effect contributed to an increase in functional parameters. Analysis of the results of static automatic perimetry showed a positive trend in the mean deviation (MD) and standard deviation pattern (PSD), which may indicate a neuroprotective effect of the drug. All patients noted good tolerability of treatment. Throughout the observation period, patients maintained a high level of adherence and performance.
Tactics of Managing Patients with Bacterial Corneal Ulcers in a Multidisciplinary Hospital (Series of Clinical Cases)
Authors: Arzhimatova G. S. , Chernakova G. M. , Shirshova E. V. , Shemyakin M. Yu. , Emelyanova E. B. , Ugolnikova A. O.
Published: October 2023

Bacterial corneal ulcers in patients with comorbid pathology are a complex clinical situation with a high risk of complications — corneal perforation. The article presents four clinical cases of bacterial corneal ulcers in patients with chronic latent sinusitis. The publication discusses the issues of diagnostic tactics, provides an analysis of the results of instrumental and laboratory tests in each case. The results of corneal ulcer therapy are presented taking into account antibioticograms.
A family case Williams – Campbell syndrome in clinical practice
Authors: Stezhkina E. V. , Belykh N. A. , Arsenina V. S. , Chaplanov M. V. , Deeva Yu. V. , Burceva A. A.
Published: October 2023

Currently, among all pathologies of the respiratory system, bronchiectasis receives special attention. This is due to its increasing incidence and the improvement of diagnostic methods. Williams – Campbell syndrome is a congenital form of bronchiectasis characterized by a defect or complete absence of bronchial wall cartilage in the subsegmental bronchi. In view of this, medical personnel should be familiar with the basics of differential diagnosis and treatment, as well as the prognosis of this disease. The aim of this paper is to present a clinical family case of Williams – Campbell syndrome. The father of the family was diagnosed with WCS at the age of 3 years by bronchography, and his daughter has all clinical signs of this disease today. To date, the question remains as how to diagnose WCS and monitor the patient’s health in the future. Conclusion. Physicians of all specialties should be informed about rare diseases.
Hemodynamic and motion demands of soccer referees: a comparison between series A and B of the State Championship of Rio de Janeiro, Brazil
Authors: de Lima e Silva Leandro , Gomes de Souza Vale Rodrigo , Borba Neves Eduardo , Brandão Pinto de Castro Juliana , Salum de Godoy Erik , Baptista da Silva Jurandir , Leilane Silva Magna , de Alkmim Moreira Nunes Rodolfo
Published: October 2023

Introduction: Soccer referees need excellent conditioning to withstand the physical and psychological demands of games. Objective: To compare the hemodynamic variables, speed, cadence, and distance coursed of referees during soccer games of series A and B in Rio de Janeiro, Brazil. Material and method: The total number of decisions made during the 10 soccer matches evaluated was 1,224 observable decisions of 10 professional Soccer referees (one per soccer match: 5 in series A and 5 in series B). We used a frequency meter (Polar, model V800, PolarFlow software) and video footage of the games (Sony, model PXW-Z150, 4K). The moments considered were: the decision, 15 seconds that preceded it, and the period from the beginning of each stage to each decision. Were studied the hemodynamic [average heat rate (mean HR), maximum heart rate (HRmax), and minimum heart rate (HRmin)] and motion variables [average speed (Vmed), maximum speed (Vmax), average cadence (cadencemed), maximum cadence (cadencemax), minimum cadence (cadencemin), and distance covered]. Descriptive measures were used to present the results of the variables studied and the Student’s T-Test for independent samples to test the study hypotheses. The significance level was set at 95% (P <0.05). Results: The matches of series A had a greater number of interventions and greater hemodynamic load at the exact moment of the decision than those of series B. significantly (P <0.05): mean HR, HRmax, HRmin, Vmax, Cadencemed, and Cadencemax in series A were higher compared to series B. In the 15 seconds before the decisions: mean HR, HRmax, and HRmin in series A were higher than in series B, and Vmed in series B was higher in relation to series A. At the exact moment of the decisions: mean HR in series A was higher in relation to series B. Conclusion: Referees’ interventions are generally carried out under high hemodynamic pressure. The matches played in the A series require a higher number of interventions and hemodynamic intensity than the matches in the series B under high hemodynamic pressure, other psychological factors may play a role; however, this needs to be studied in greater depth.
Adductor functionality and strength in high-level rink hockey players
Authors: Quintana-Cepedal Marcos , Pedrero-Martin Yolanda , de la Calle Omar , Medina-Sánchez María , del Valle Miguel , Olmedillas Hugo
Published: October 2023

Objective: To evaluate adductor strength and groin function in high level rink hockey players and its relationship with groin pain in the previous season. Material and method: A cross-sectional study was performed where hip/groin strength and function was assessed via 5 seconds Squeeze Test and Hip and Groin Ouctome Score in 11 high level rink hockey players. Results: Overall prevalence for groin pain was 81.8% (54% of the participants suffered groin pain during the previous season), and 18.2% suffered time-loss groin pain. Mean strength in the 5SST was 254.68N (3.25Nm/Kg) and HAGOS questionnaire reached 90/100 points in the whole sample. Similar adductor strength values were observed between healthy athletes and previously injured who suffered time-loss groin pain (P=0.261-0.948; g: 0.04-0.85). Statistically significant differences were found for the following HAGOS subscales: Pain, function, sports and recreational activities, and quality of life between groups (P=0.005-0.042; g: 0.34-2.65; r: 0.3-0.61). Conclusion: More than a half of the participants suffered groin pain, of which one third suffered time-loss groin pain. Function assessed via HAGOS seems to be the main proxy that discriminates between groups. Medical staff should implement this questionnaire to detect and avoid the progression of this injury
Sistema de cultivo sobre o solo para palmas forrageiras resistentes a cochonilha-do-carmim
Authors: Nascimento Zulmira Dayana Santos , Rezende Letícia Nunes , Pontes Jailyne Costa , Machado Neto Geovani José , Oliveira Ângelo Kidelman Dantas de , Oliveira Fernando Kidelmar Dantas de
Published: October 2023

A palma forrageira é uma das plantas mais cultivadas no semiárido brasileiro. Apesar de sua alta capacidade de adaptação em áreas com escassez de chuvas é vulnerável a doenças e pragas, sendo a mais importante à cochonilha-do-carmim (Dactylopius opuntiae Cockerell) que destrói os palmais no semiárido nordestino, tornando-se o principal impasse no cultivo da palma. Em razão disto, esta pesquisa teve como objetivo avaliar o desempenho das espécies de palma forrageira Opuntia sp., Opuntia stricta, Nopalea cochenillifera, consideradas resistentes à referida praga, implantadas de maneira convencional comparando-as ao sistema de cultivo sobre o solo em período de déficit hídrico. O experimento foi conduzido no município de Jaçanã, Rio Grande do Norte. Foi adotado delineamento experimental em blocos casualizados, em esquema fatorial com seis tratamentos cognominados de cultivo convencional e sistema de cultivo sobre o solo com as três espécies com duração de 12 meses. Os resultados mostraram que o desempenho dos sistemas de cultivo das variedades com recorte temporal no período de estiagem foi semelhante em ambos os sistemas de cultivo, em relação às variáveis: emissão e fixação de raízes, emissão de novos cladódios. Os dois sistemas de cultivo proporcionam desempenho semelhante em relação ao cultivo das variedades investigadas.
First record of giant anteater (Myrmecophaga tridactyla - Myrmecophagidae) in Campos das Vertentes, Minas Gerais
Authors: De Sousa Oliveira Glauco Cássio , Pereira de Gouvêa Taiguara , Magalhães de Souza Marcos
Published: October 2023

The species Myrmecophaga tridactyla, Myrmecophagidae, is widely distributed in the Neotropics regions and is popularlyknown as the giant anteater. It is considered a generalist species regarding habitat and can be found in human-modifiedareas such as pastures and crops. However, there is limited information about the species in agricultural ecosystems. Dueto its threatened status and the absence of records in the Campos das Vertentes region, which has only 1.04% of its areaincluded in Conservation Units, this study aimed to report the unprecedented occurrence of M. tridactyla in the municipalityof Ritápolis, Campos das Vertentes, Minas Gerais, in a transitional region between the Atlantic Forest and the Cerrado. Twooccasional records were made on a rural road in this municipality. Therefore, this record increases our knowledge about thespatial distribution of M. tridactyla in the state of Minas Gerais, provides information about the species in human-modifiedlandscapes, and supports the need for more Conservation Units in the Campos das Vertentes region.
Cognitive - Behavioural Coping Strategies as Predictor of Suicide Risk Severity
Authors: Nicoară Romulus-Dan , Nicoară Ana-Maria , Cosman Doina , Coman Horia-George
Published: October 2023

Background and aim: Cognitive behavioural coping strategies are closely correlated with depression and suicide risk. The aim of this study is to explore the particular features of cognitive-behavioural coping strategies and their impact on depression levels and suicidal ideation.
            Methods: The study included a total of 131 participants, of whom 65 had a clinical diagnosis of depression and 66 were controls. Psychometric tools were administered to both groups: Montgomery-Asberg Depression Scale (MADRS), Depression Anxiety Stress Scale (DASS21R), Strategic approach to coping scale (SACS), Columbia Suicide Severity Rating Scale (C-SSRS), in order to assess the differences between depressive and non-depressive individuals in relation to cognitive behavioural coping strategies.
            Results and conclusion: Results based on statistical analysis of scores obtained on various psychometric scales showed significant differences between depressed and non-depressed patients. Also, cognitive-behavioural strategies could represent predictors that can be used in the prevention of suicide risk.
Relationship between Feelings and Risk of Burnout Syndrome to the Medical Staff in the Emergency Department of Galati Hospital During the Covid 19 Pandemic Period
Authors: Marina Virginia , Moscu Cosmina-Alina , Anghele Aurelian-Dumitrache , Anghele Mihaela , Dragomir Liliana , Ciubara Anamaria
Published: October 2023

Introduction: Burnout syndrome is a manifestation of chronic stress caused by occupational stressors. The large number of patients infected with SARS Covid 2 has had a particular psychological impact on medical staff in Emergency Departments and only. Material and Methods: This was a descriptive study, of medical staff in the Emergency Department of the Galati County Emergency Hospital, which is in the front line in the fight against coronavirus. All 120 participants signed an informed consent form and then completed a socio-demographic questionnaire, self-designed questionnaire to identify feelings experienced at work during Covid- 19 Pandemic and the MBI - HSS (MP) (Maslach Burnout Inventory) to assess their burnout level. Results: The study found that 45% of the subjects were at high risk of Burnout. Medical staff in the Emergency Department show a degree of Burnout syndrome directly proportional to their experience in the field. Conclusions: The prevalence of Burnout syndrome in the Emergency Department is high, more than half of the physicians suffer from a high level of Burnout. Older age and less experience in the field and female gender are predictive factors for Burnout syndrome. Self-reported risk factors are increased overtime, workload, bureaucracy, lack of sleep, lack of respect from patients and colleagues, fear of exposure to the virus and patient care. Self-reported feelings of exhaustion, stress, and depression are dependent on symptoms of Burnout syndrome.
A Child-Centered Approach to the Organization of the Educational Process in the New Ukrainian Elementary School of Neuropsychology
Authors: Bilier Oksana , Vasko Olha , Hrynko Victoriia , Melnyk Oleksandr , Hurkova Tetiana , Korolova Liudmyla
Published: October 2023

The educational process in the new Ukrainian elementary school is characterized by many specific neuropsychological features and aspects. It requires from the teacher significant knowledge and skills in the field of organization, management and modernization of the educational process, as well as in the sphere of interaction with the children of the new Ukrainian elementary school. A key trend in today's education in the new Ukrainian elementary school is the child-centered approach, individualization and personality-centered approach, which focuses on the fact that the core of the educational process becomes the student, his abilities, individual neuropsychological capabilities, potential as a learning and creative. The child-centered approach to the organization of the educational process in the new Ukrainian elementary school has become a natural and natural phenomenon that accompanies the learning process in the last few years, which is caused by the rapid processes of globalization. The child-centered approach allows to focus the attention of teachers, psychologists, sociologists, and educational managers on the key problem of the current world - education of a healthy civil society, self-confident, capable of self-care, self-actualization, and professional and personal formation. All these processes begin at the moment when the child is in the first stage of education, receives primary information about the world, about himself, others and reality.
Development of a Simulation Environment for the Importance of Histone Deacetylase in Childhood Acute Leukemia with Explainable Artificial Inteligence
Authors: Uysal Ilhan , Kose Utku
Published: October 2023

This study aims to explore new therapeutic opportunities for histone deacetylase (HDAC) inhibitors by leveraging drug repurposing approaches and analyzing their bioactivity and molecular fingerprints. The methodology includes investigating drug repurposing opportunities for HDAC inhibitors, evaluating the bioactivity of repurposing drugs on HDAC enzymes, investigating the role of HDAC genes in therapeutic effects, and analyzing molecular fingerprints with explainable artificial intelligence (XAI) to identify structurally similar compounds with potential HDAC inhibitory activity. In this context, chemical compounds with IC50 (7903 compounds) and Inhibition (1084 compounds) standard types of HDAC genes reported to be associated with childhood acute leukemia were represented by molecular fingerprints. Regression and classification models were applied to the molecular fingerprints, and the results obtained were supported by XAI. All the study results were shared interactively on the website address https://iuysal1905-childhoodacuteleukemia-drug-interacito-arayuz-r89zld.streamlit.app/ by designing a simulation environment.
The influence of molecular fingerprints on the models and their impact on potential drug development in childhood acute leukemia were evaluated using XAI techniques, particularly through the analysis of SHAP values. The study contributes to the literature on the use of XAI technology in drug repurposing studies, especially in cancer, the study of molecular properties, and the active use of XAI in drug repurposing studies
Enhancing Professional Competence of Future Vocal Teachers through Analyzing Current Music Culture: the Neuroaesthetic Outlook
Authors: Pechenyuk Mayia , Martyniuk Liubov , Lutsenko Viktor , Shpak Halyna , Pukhalskyi Taras , Kuziv Mariia
Published: October 2023

The article attempts to comprehend the latest achievements in such a field of neuroscience as neuroaesthetics, which analyzes the nature of music and musical creativity through the prism of ontogenetic features of the human brain. Using numerous examples it is shown that the key ideas of neuroaesthetics in general correspond to the spirit of Kantian a prioriism, reinterpreted in current terms of cognitive neuroscience; an attempt is made to justify the necessity of increased attention to the urgency of updating the professional training of vocal teachers, revealed the ideal structure of the competence of a vocal coach on the basis of systematized by him views of different experts, as well as proposed to make individual principled emphasis on a comprehensive study of trends in current musical culture by students; as a conscious and purposeful familiarization with such, in his view, is an essential element in the system of today's professional competence. The personal and professional characteristics that every future vocal coach should possess are revealed in great detail; the special importance of each of these components of success in competing in the pedagogical labor market is emphasized.
In addition, key features of the dissemination of musical information in today's society, the impact of network technologies on the specialized training of teachers and recipients, the formation of the technological basis of vocal and sound culture aesthetics of academic singing of the future teacher are highlighted. As a conclusion, further, more in-depth study of the raised problems is proposed, since it is not sufficiently developed at the scientific level.
A Hierarchical Cluster Tree Approach Leveraging Delaunay Triangulation
Authors: Avatavului Cristian , Boiangiu Costin-Anton
Published: October 2023

This research introduces a robust and reliable technique for structuring document image pages hierarchically, harnessing the power of Delaunay triangulation. Central to our approach is the formation of a cluster tree, which encapsulates the page's content through strategically exploiting layout elements arrangements and their relative distances. By applying our technique, we proficiently categorize the page into distinct clusters encompassing images, titles, and paragraphs. The consequent hierarchical framework, founded on the cluster tree, establishes a durable and trustworthy blueprint of the document layout, thereby accelerating document comprehension and examination.
Here's What We See: Competency-Based Education Can Solve the Nonprofit Disciplinary Conundrum
Authors: Norris-Tirrell Dorothy , Schmidt Susan T.
Published: October 2023

Multiple disciplines and numerous theoretical foundations built the basis for study of nonprofit organizations. This article explores the disciplinary debate with data from the Nonprofit Leadership Alliance about the majors of students earning the Certified Nonprofit Professional (CNP) credential over the last 10 years. Our analysis suggests that with a focus on the competencies needed for practice, nonprofit education works in any discipline. Embedding a competency-based, applied pedagogy allows many disciplines to ensure successful outcomes for students.
Impact of Capital Structure on the Company’s Financial Situation during the Pandemic – Analysis Based on Examples of Listed Companies
Authors: Jasiniak Magdalena , Rudzki Mateusz
Published: October 2023

Under the conditions of increased uncertainty making right financial decisions can determine success or failure of every company. Maintaining financial liquidity is especially important during impactful economic fluctuations when the risk of bankruptcy rises significantly.

The purpose of the article is to evaluate the impact of financing strategies on economic situation of companies during the pandemic as well as to verify whether safe strategy can be a reliable measure of protection from the danger of bankruptcy.

Methodology. Empirical research has been based on the analysis of 30 commercial sector companies’ financial statements from 2018 to 2020. The research has been completed with discriminant analysis models, and in order to receive clear interpretation of results a new indicator has been created. The indicator shows effectiveness of financing strategies as protection from negative results of the pandemic.

Results of the research prove that under the conditions of strong and rapid economic changes a conservative strategy is a relatively safer strategy than moderate and aggressive ones, yet, it does not guarantee full protection from bankruptcy. Additionally, moderately higher risk of financing allows to increase liquidity and profitability even during the pandemic which was also indicated in the research.
Neuropsychiatric Lupus: A Review of Clinical Features and Treatment Strategies
Authors: Isabel Gomez Maria
Published: October 2023

Neuropsychiatric lupus, also known as neuropsychiatric systemic lupus erythematosus (NPSLE), is a subset of systemic lupus erythematosus (SLE) that affects the central nervous system, leading to a range of neurological and psychiatric symptoms. It occurs in approximately 25-75% of SLE patients, varying prevalence across populations. NPSLE primarily affects women of childbearing age but can occur in individuals of any age or gender, with a higher prevalence among non-Caucasian populations and those with severe SLE symptoms. The exact cause of NPSLE is complex, involving immune dysregulation, autoantibody production, and central nervous system inflammation. Autoantibodies, such as anti-phospholipid and anti-NMDA receptor antibodies, may significantly affect neurological symptoms. Immune-complex deposition and proinflammatory cytokines within the brain contribute to the disease’s pathophysiology. NPSLE encompasses many symptoms, including cognitive impairment, mood disorders, psychosis, seizures, and headaches. Diagnosis relies on clinical evaluation, neuroimaging, cerebrospinal fluid analysis, and autoantibody testing. A multidisciplinary approach involving rheumatologists, neurologists, and psychiatrists is often necessary. Treatment for NPSLE is tailored to the specific symptoms and their severity. It typically involves immunosuppressive therapies like corticosteroids, diseasemodifying antirheumatic drugs (DMARDs), and sometimes biological agents. Adjunctive therapies, including antiepileptic drugs, antipsychotics, and antidepressants, may be necessary for symptom management. Regular monitoring and follow-up are crucial to assess treatment response.