bluuebunny/crossref_metadata_2025 huggingface dataset:
Permeability of rock discontinuities and faults in the Triassic Sherwood Sandstone Group (UK): insights for management of fluvio-aeolian aquifers worldwide
Authors: Medici Giacomo , West L. Jared , Mountney Nigel P. , Welch Michael
Published: October 2019

Fluvio-aeolian sedimentary successions host groundwater aquifers at shallow depths (<~0.15 km), which overlie geothermal and shale-gas reservoirs, and nuclear waste repositories at intermediate depths (~0.15–2.0 km). Additionally, such deposits represent petroleum reservoirs at greater depths (~2.0–4.0 km). The need to improve conceptual understanding of the hydraulic behaviour of fluvial-aeolian sandstone successions over a large depth interval (~0–4 km) is important for socio-economic reasons. Thus, the hydraulic properties of the Triassic Sherwood Sandstone aquifer in the UK have been reviewed and compared to similar fluvio-aeolian successions. The ratio between well-scale and core-plug-scale permeability (Kwell-test/Kcore-plug) acts as a proxy for the relative importance of fracture versus intergranular flow. This ratio (which typically varies from ~2 to 100) indicates significant contribution of fractures to flow at relatively shallow depths (<~0.15 km). Here, permeability development is controlled by dissolution of calcite-dolomite in correspondence of fractures. The observed ratio (Kwell-test/Kcore-plug) decreases with depth, approaching unity, indicating that intergranular flow dominates at ~1 km depth. At depths ≥ ~1 km, dissolution of carbonate cement by rock alteration due to groundwater flow is absent and fractures are closed. Aeolian and fluvial deposits behave differently in proximity to normal faults in the Sherwood Sandstone aquifer. Deformation bands in aeolian dune deposits strongly compartmentalize this aquifer. The hydro-structural properties of fluvio-aeolian deposits are also controlled by mineralogy in fault zones. A relative abundance of quartz vs. feldspar and clays in aeolian sandstones favours development of low-permeability deformation bands.
Correction to: Semi-automatic segmentation from intrinsically-registered 18F-FDG–PET/MRI for treatment response assessment in a breast cancer cohort: comparison to manual DCE–MRI
Authors: Andreassen Maren Marie Sjaastad , Goa Pål Erik , Sjøbakk Torill Eidhammer , Hedayati Roja , Eikesdal Hans Petter , Deng Callie , Østlie Agnes , Lundgren Steinar , Bathen Tone Frost , Jerome Neil Peter
Published: October 2019

The original version of this article unfortunately contained a mistake in Fig. 6.
Opening the black box of selection
Authors: Schreurs Sanne , Cleutjens Kitty , Collares Carlos F. , Cleland Jennifer , oude Egbrink Mirjam G. A.
Published: October 2019

Medical school selection is currently in the paradoxical situation in which selection tools may predict study outcomes, but which constructs are actually doing the predicting is unknown (the ‘black box of selection’). Therefore, our research focused on those constructs, answering the question: do the internal structures of the tests in an outcome-based selection procedure reflect the content that was intended to be measured? Downing’s validity framework was applied to organize evidence for construct validity, focusing on evidence related to content and internal structure. The applied selection procedure was a multi-tool, CanMEDS-based procedure comprised of a video-based situational judgement test (focused on (inter)personal competencies), and a written aptitude test (reflecting a broader array of CanMEDS competencies). First, we examined content-related evidence pertaining to the creation and application of the competency-based selection blueprint and found that the set-up of the selection procedure was a robust, transparent and replicable process. Second, the internal structure of the selection tests was investigated by connecting applicants’ performance on the selection tests to the predetermined blueprint using cognitive diagnostic modeling. The data indicate 89% overlap between the expected and measured constructs. Our results support the notion that the focus placed on creating the right content and following a competency-blueprint was effective in terms of internal structure: most items measured what they were intended to measure. This way of linking a predetermined blueprint to the applicants’ results sheds light into the ‘black box of selection’ and can be used to support the construct validity of selection procedures.
Changing trends in liver cancer incidence by race/ethnicity and sex in the US: 1992–2016
Authors: Salvatore Maxwell , Jeon Jihyoun , Meza Rafael
Published: October 2019

Purpose

Liver cancer incidence continues to increase while incidence of most other cancers is decreasing. We analyze recent and long-term trends of US liver cancer incidence by race/ethnicity and sex to best understand where to focus preventive efforts.

Methods

Liver cancer incidence rates from 1992 to 2016 were obtained from the Surveillance, Epidemiology, and End Results registry. Delay-adjusted age-standardized incidence trends by race/ethnicity and sex were analyzed using joinpoint regression. Age-specific incidence was analyzed using age-period-cohort models. Hepatitis C seroprevalence by cohort was calculated using National Health and Nutrition Examination Survey data.

Results

Liver cancer incidence has peaked in males and Asian or Pacific Islanders. Hispanic males, a high-incidence population, are experiencing a decrease in incidence, although not yet statistically significant. In contrast, incidence continues to increase in females, although at lower rates than in the 1990s, and American Indian/Alaska Natives (AI/ANs). Liver cancer incidence continues to be higher in males. Non-Hispanic Whites have the lowest incidence among racial/ethnic groups. Trends largely reflect differences in incidence by birth-cohort, which increased considerably, particularly in males, for those born around the 1950s, and continues to increase in females and AI/ANs. The patterns in males are likely driven by cohort variations in Hepatitis C infection.

Conclusions

Liver cancer incidence appears to have peaked among males. However, important differences in liver cancer trends by race/ethnicity and sex remain, highlighting the need for monitoring trends across different groups. Preventive interventions should focus on existing liver cancer disparities, targeting AI/ANs, females, and high-incidence groups.
A double dissociative study into the effectiveness of computational thinking
Authors: Calderon Ana C. , Skillicorn Deiniol , Watt Andrew , Perham Nick
Published: October 2019

We propose the first steps towards a rigorous analysis of the effectiveness of an emerging pedagogy, Computational Thinking. We found that two aspects of the pedagogy have a positive effect with regard to enhancing two cognitive processes, namely sequential thinking and in abstract thinking. Our data was gathered experimentally with a cohort of mixed-ability undergraduate students enrolled on three distinct courses. The study employed a mixed 2 × 2 factorial design with type of classroom intervention, measurements were taken at baseline and following delivery of computational thinking methodologies designed to focus on specific components of the pedagogy. The dependent variable was percentage improvement from baseline, and the analyses were conducted using 2 × 2 mixed ANOVA, an alpha criterion of p < .05 was adopted for all analyses. The specific components investigated were algorithmic thinking and abstraction, and we found a positive correlation between enhancements of sequentiality and abstract thinking.
Regularization by Architecture: A Deep Prior Approach for Inverse Problems
Authors: Dittmer Sören , Kluth Tobias , Maass Peter , Otero Baguer Daniel
Published: October 2019

The present paper studies so-called deep image prior (DIP) techniques in the context of ill-posed inverse problems. DIP networks have been recently introduced for applications in image processing; also first experimental results for applying DIP to inverse problems have been reported. This paper aims at discussing different interpretations of DIP and to obtain analytic results for specific network designs and linear operators. The main contribution is to introduce the idea of viewing these approaches as the optimization of Tikhonov functionals rather than optimizing networks. Besides theoretical results, we present numerical verifications.
Snapshot of proton pump inhibitors prescriptions in a tertiary care hospital in Switzerland: less is more?
Authors: Lenoir Camille , El Biali Myriam , Luthy Christophe , Grosgurin Olivier , Desmeules Jules Alexandre , Rollason Victoria
Published: October 2019

BackgroundProton pump inhibitors are among the most widely prescribed drugs in the world, but more than half of the indications for prescription are unjustified. The misuse of this therapeutic class has heavy consequences such as additional health costs, adverse drug reactions following long-term use and gastric acid rebound when the proton pump inhibitor is discontinued.ObjectiveThe overprescription of proton pump inhibitors is therefore becoming a public health problem, which led us to evaluate their use within the Geneva University Hospitals.SettingPatients hospitalized in two divisions of the department of internal medicine of the Geneva University Hospitals on a single day.MethodsThis is a register-based cross-sectional study and it collected data about the prescription pattern of proton pump inhibitors by consulting the electronic records of patients included.Main outcome measureTo determine if the proton pump inhibitors prescription is made according to the market authorization and the available guidelines.ResultsHundred-eighty patients were included. 54% of patients were on proton pump inhibitors, 29% of whom had their treatment initiated at hospital. Of the indications for treatment, 72% were not justified and 63% of the justified indications did not have an adequate dosage. Therefore, in all patients with a proton pump inhibitor at hospital, only 11% had a justified indication with an adequate dose. Finally, 87% of known home prescriptions were renewed on admission and among them, 71% did not have a justified or possibly justified indication according to the guidelines.ConclusionIndication for treatment inside the hospital was not justified in 72% of patients and only 11% had a justified indication with an adequate dosage. Precise guidelines with evidence-based indications and adequate daily doses would help to correctly prescribe proton pump inhibitors. Moreover, patients should benefit from a thorough evaluation of their treatment.
Nutritional Status from 1 to 15 Years and Adolescent Learning for Boys and Girls in Ethiopia, India, Peru, and Vietnam
Authors: Aurino Elisabetta , Schott Whitney , Behrman Jere R. , Penny Mary
Published: October 2019

There has been little examination of: (1) associations of early-life nutrition and adolescent cognitive skills, (2) if they vary by gender, (3) if they differ by diverse contexts, and (4) contributions of post-infancy growth to adolescent cognitive attainment. We use Young Lives data on 7687 children from Ethiopia, India, Peru, and Vietnam to undertake ordinary least squares estimates of associations between age-1 height-for-age z-score (HAZ) and age-15 cognitive outcomes (math, reading, vocabulary), controlling for child and household factors. Age-1 HAZ is positively associated with cognitive scores in all countries. Child gender-specific estimates for these coefficients either do not differ (math, reading) or favor girls (vocabulary). Augmenting models to include growth in HAZ between ages 1 and 15 years that was not predicted by HAZ at age 1 reveals that such improvements are associated with higher cognitive scores, but that sex-specific coefficients for this predictor favor boys in India and Peru. The results suggest that nutritional indicators at age 1 have gender-neutral associations with math and reading and favor girls for vocabulary achievement at age 15, but unpredicted improvements in HAZ by adolescence are associated with higher cognitive scores for boys than for girls. This evidence enriches our understanding of relationships between children’s nutritional trajectories during childhood and adolescent cognitive development, and how these associations vary by gender in some contexts to the possible disadvantage of girls.
Data mining algorithms for bridge health monitoring: Kohonen clustering and LSTM prediction approaches
Authors: Guo Aiping , Jiang Ajuan , Lin Jie , Li Xiaoxiao
Published: October 2019

In recent years, bridge health monitoring system has been widely used to deal with massive data produced with the continuous growth of monitoring time. However, how to effectively use these data to comprehensively analyze the state of a bridge and provide early warning of bridge structure changes is an important topic in bridge engineering research. This paper utilizes two algorithms to deal with the massive data, namely Kohonen neural network and long short-term memory (LSTM) neural network. The main contribution of this study is using the two algorithms for health state evaluation of bridges. The Kohonen clustering method is shown to be effective for getting classification pattern in normal operating condition and is straightforward for outliers detection. In addition, the LSTM prediction method has an excellent prediction capability which can be used to predict the future deflection values with good accuracy and mean square error. The predicted deflections agree with the true deflections, which indicate that the LSTM method can be utilized to obtain the deflection value of structure. What’s more, we can observe the changing trend of bridge structure by comparing the predicted value with its limit value under normal operation.
On the Crystallinity and Durability of ZDDP Tribofilm
Authors: Ueda Mao , Kadiric Amir , Spikes Hugh
Published: October 2019

The current trend for using lower-viscosity lubricants with the aim of improving fuel economy of mechanical systems means that machine components are required to operate for longer periods in thin oil film, mixed lubrication conditions, where the risk of surface damage is increased. Consequently, the performance and durability of the tribofilms formed by antiwear additives, and in particular zinc dialkyldithiophosphate (ZDDP), the main antiwear oil additive used in engine oils, has become an increasingly important issue. In this paper, it is confirmed that ZDDP tribofilms are initially relatively easily removed by rubbing but that they become more durable during prolonged rubbing. FIB-TEM analyses at different stages of tribofilm formation show that during the early stages of rubbing only the tribofilm close to the steel substrate is nanocrystalline, while the outer region is amorphous and easily removed. However, after prolonged rubbing all regions of the tribofilm become nanocrystalline and able to withstand rubbing in base oil without being removed. XPS analysis shows that after extended rubbing the outermost polyphosphate structures change from longer-chain structures such as metaphosphate and polyphosphate to shorter-chain structures including orthophosphate. This depolymerization of ZDDP tribofilm from long- to short-chain phosphate and consequent nanocrystallization are driven by heat and shear stress. EDX analysis shows that this conversion is promoted by diffusion of Fe cation into the bulk of the tribofilm. The finding that ZDDP tribofilms evolve during rubbing from a weaker amorphous structure to a more durable nanocrystalline one has important implications in terms of the behaviour of ZDDPs at low concentrations, on non-metallic surfaces and at very high contact pressures, as well as for the development of ZDDP tribofilm, friction and wear models.
Mental Health Problems and Associated Predictors Among Bangladeshi Students
Authors: Mamun Mohammed A. , Hossain Md. Sharif , Griffiths Mark D.
Published: October 2019

Common mental health problems are regarded as public health concerns and can contribute to risky behaviors such as suicide among university students in extreme cases. However, there is a lack of studies concerning such issues in Bangladesh. The present study aimed to fill this knowledge gap by investigating the prevalence and associated risk predictors of depression, anxiety, and stress among Bangladeshi university students. The sample comprised 590 undergraduates attending Jahangirnagar University (Dhaka, Bangladesh) who completed an offline survey including sociodemographic questions, behavioral variables, and the 21-item Bangla Depression, Anxiety and Stress Scale (BDASS-21). The prevalence of moderate to the extremely severe levels of depression, anxiety, and stress was 52.2%, 58.1%, and 24.9%, respectively. There were no significant gender differences in depression, anxiety, and stress. Risk factors for depression included coming from a lower class family, being a cigarette smoker, and engaging in less physical exercise. Risk factors for anxiety and stress included being engaged in a relationship. The findings need to be further replicated among other Bangladeshi university students to help in the development of better intervention programs and appropriate support services targeting this vulnerable group including a focus of suicide prevention and awareness.
A Parametric Study of the Vacuum Arc Remelting (VAR) Process: Effects of Arc Radius, Side-Arcing, and Gas Cooling
Authors: Karimi-Sibaki E. , Kharicha A. , Wu M. , Ludwig A. , Bohacek J.
Published: October 2019

Main modeling challenges for vacuum arc remelting (VAR) are briefly highlighted concerning various involving phenomena during the process such as formation and movement of cathode spots on the surface of electrode, the vacuum plasma, side-arcing, the thermal radiation in the vacuum region, magnetohydrodynamics (MHD) in the molten pool, melting of the electrode, and solidification of the ingot. A numerical model is proposed to investigate the influence of several decisive parameters such as arc mode (diffusive or constricted), amount of side-arcing, and gas cooling of shrinkage gap at mold–ingot interface on the solidification behavior of a Titanium-based (Ti-6Al-4V) VAR ingot. The electromagnetic and thermal fields are solved in the entire system including the electrode, vacuum plasma, ingot, and mold. The flow field in the molten pool and the solidification pool profile are computed. The depth of molten pool decreases as the radius of arc increases. With the decreasing amount of side-arcing, the depth of the molten pool increases. Furthermore, gas cooling fairly improves the internal quality of ingot (shallow pool depth) without affecting hydrodynamics in the molten pool. Modeling results are validated against an experiment.
A prospective comparison of short-term results after arthroscopic and open elbow procedures in elbow stiffness
Authors: Leschinger T. , Hackl M. , Lenz M. , Rausch V. , Müller L. P. , Wegmann K.
Published: October 2019

Background

Surgical treatment of the stiff elbow can be performed either arthroscopically or via an open approach. There is a paucity of direct prospective comparisons of the techniques in the literature.

Objectives

The aim of the study is to analyze the clinical short-term results of arthroscopic and open elbow arthrolysis in postoperative and posttraumatic stiff elbows.

Materials and methods

The study group consisted of 44 patients divided in two cohorts, one after arthroscopic arthrolysis (33 patients) and the other including patients after open arthrolysis (11 patients). Range of motion (ROM; extension/flexion), pain (numerical rating scale, NRS), as well as the disabilities of the arm, shoulder, and hand (DASH) score were recorded preoperatively and examined in a standardized manner 6 weeks, 3 months, and 6 months after surgery.

Results

In both groups, preoperative elbow movement significantly improved in the follow-up. An increase from 103.3° (±23.4) to 123.5° (±12.5°; p = 0.001) was seen after 6 months for the arthroscopic group, whereas the mean ROM significantly increased from 64.5° (±31.1°) to 100.9° (±25.6°; p = 0.007) following open arthrolysis.

In the arthroscopic group, the DASH score was measured at 37.3 points (±23.4 points) and improved to 16.1 points (±16.5 points) after 6 months, while in the open group it enhanced after 6 months (19.5 points [±17.5 points]) compared to its preoperative value by 38.2 points (±24.1 points). A consistent improvement was found for NRS, which decreased after surgery in both groups (arthroscopic group = −3.1 [±3.0]; open group = −2.0 [±2.9]). Complications did not occur in either group. When comparing delta values of the groups between the preoperative ROM, DASH score, and NRS, no significant differences were observed (p < 0.05).

Conclusions

Good to excellent functional recovery was seen in both cohorts when evaluating for improvement in the DASH score, the gain in elbow motion, and the decrease in pain. No significant differences were found between the procedures regarding pre- and postoperative measurements. The arthroscopic approach has developed to become an effective alternative to treat posttraumatic elbow stiffness.
Identification of PP2A and S6 Kinase as Modifiers of Leucine-Rich Repeat Kinase-Induced Neurotoxicity
Authors: Sim Joan Poh Ling , Ziyin Wang , Basil Adeline Henry , Lin Shuping , Chen Zhongcan , Zhang Chengwu , Zeng Li , Cai Yu , Lim Kah-Leong
Published: October 2019

Mutations in LRRK2 are currently recognized as the most common monogenetic cause of Parkinsonism. The elevation of kinase activity of LRRK2 that frequently accompanies its mutations is widely thought to contribute to its toxicity. Accordingly, many groups have developed LRRK2-specific kinase inhibitors as a potential therapeutic strategy. Given that protein phosphorylation is a reversible event, we sought to elucidate the phosphatase(s) that can reverse LRRK2-mediated phosphorylation, with the view that targeting this phosphatase(s) may similarly be beneficial. Using an unbiased RNAi phosphatase screen conducted in a Drosophila LRRK2 model, we identified PP2A as a genetic modulator of LRRK2-induced neurotoxicity. Further, we also identified ribosomal S6 kinase (S6K), a target of PP2A, as a novel regulator of LRRK2 function. Finally, we showed that modulation of PP2A or S6K activities ameliorates LRRK2-associated disease phenotype in Drosophila.
Meta-analysis of Nekton Utilization of Coastal Habitats in the Northern Gulf of Mexico
Authors: Hollweg Terill A. , Christman Mary C. , Cebrian Just , Wallace Bryan P. , Friedman Scott L. , Ballestero Heather R. , Huisenga Mary T. , Benson Kristopher G.
Published: October 2019

Estuaries in the northern Gulf of Mexico (GOM) provide habitat for many ecologically, commercially, and recreationally important fish and crustacean species (i.e., nekton), but patterns of nekton abundance and community assemblages across habitat types, salinity zones, and seasons have not been described region-wide. Recognizing the wealth of information collected from previous and ongoing field sampling efforts, we developed a meta-analytical approach to aggregate nekton density data from separate studies (using different gear types) that can be used to answer key research questions. We then applied this meta-analytical approach to separate nekton datasets from studies conducted in the Gulf of Mexico to summarize patterns in nekton density across and within several estuarine habitat types, including marsh, oyster reefs, submerged aquatic vegetation (SAV), and open-water non-vegetated bottom (NVB). The results of the meta-analysis highlighted several important patterns of nekton use associated with these habitat types. Nekton densities were higher in structured estuarine habitats (i.e., marsh, oyster reefs, SAV) than in open-water NVB habitat. Marsh and SAV community assemblages were relatively similar to each other, but different from those associated with open-water NVB and oyster habitats. Densities of commercially and recreationally important crustacean and fish species were highest in saline marshes, thus demonstrating the importance of this habitat in the northern GOM. The results of our meta-analysis are generally consistent with previous site-specific studies in the region (many of which were included in the meta-analysis) and provide further evidence for these patterns at a regional scale. This meta-analytical approach is easy to implement for diverse research and management purposes, and provides the opportunity to advance understanding of the value and role of coastal habitats to nekton communities.
Hydrochemical evaluation of groundwater quality of the Tista floodplain, Rangpur, Bangladesh
Authors: Saha Sudip , Reza A. H. M. Selim , Roy Mrinal Kanti
Published: October 2019

The Tista is a Trans-Himalayan river that flows through Sikkim and West Bengal states of India and Rangpur division of Bangladesh and finally falls into the Brahmaputra River. The presence of numerous abandoned channels with various degrees of aggradations indicates large migrations of the Tista River. The pH value of groundwater varies from 6.20 to 7.40 which indicate the slightly alkaline to acidic nature of the studied aquifers. The mean abundance of major cations is Na+ > Ca+2 > Mg+2 > K+, whereas the major anions is HCO3− > Cl− > SO4−2. Among the cations, Na+ is the dominant and K+ is the lowest constituents, whereas HCO3− is most abundant and SO4−2 is the minor constituents in anions. The hydrochemical facies of groundwater show that sodium, sodium–magnesium, sodium–calcium, sodium–magnesium–calcium and sodium–calcium–magnesium are cation facies and chloride–bicarbonate, bicarbonate–chloride and bicarbonate are anion facies. Correlating with WHO (Guidelines for drinking-water quality, 1, World Health Organisation, Geneva, 1997) and EQS (Environmental quality standard, Department of Environment, Bangladesh, 1989) guideline values for drinking water and public health, it may be concluded that the groundwater of the study area is suitable for all drinking and domestic purposes, where only three samples exceed the maximum allowable limit of potassium. Based on total hardness, SAR, RSC, PI, SSP and MH values, it can be summarized that the groundwater of the investigated area is suitable for irrigation purpose. On the basis of Australian and UNESCO standard, the groundwater of the study area is also suitable for livestock purposes. The Rangpur area is hydrogeologically active by the processes like ion exchange and dissolution. Ca2+, Mg2+ and HCO3− are produced by the dissolution of limestone and dolomite.
A review of critical perspectives on private land conservation in academic literature
Authors: Gooden Jennifer , ‘t Sas-Rolfes Michael
Published: October 2019

In recent years, private land conservation has increased in profile among policymakers and academics. Conservation initiatives on privately owned land help to mitigate global biodiversity loss and introduce new actors to conservation. However, they have also been the subject of numerous critical accounts. This review catalogs issues that emerge in critical literature, identifying 25 themes, classified into three groups: Implementation Effectiveness, Value Conflict, and Economic Inefficiency. Gaps in the literature include the need for broader geographic coverage; assessment of the issues’ specificity to private land conservation; and evaluation of the extent to which issues in the literature reflect broader societal values. The literature’s strong emphasis on value conflict suggests that greater attention to governance effectiveness may steer private land conservation toward practices that are more just, equitable, and representative and lead to increased societal support. We recommend further research to address identified gaps, with a greater orientation toward inclusive governance.
The effect of previous treatment with bisphosphonate and renal impairment on the response to denosumab in osteoporosis: a ‘real-life’ study
Authors: Fraser T. R. , Flogaitis I. , Moore A. E. , Hampson G.
Published: October 2019

Purpose

To investigate changes in bone mineral density (BMD) following denosumab after previous bisphosphonate therapy and the impact of chronic kidney disease (CKD) on response.

Methods

A retrospective study of 134 patients (11 M, 123 F) aged [mean (SD)] 72 [11] years on denosumab was undertaken. Ninety-five patients had previously been on oral and 28 on iv bisphosphonate. Lumbar spine (LS), total hip (TH) and femoral neck (FN) BMD were measured before treatment and at 2.7 [1.2] years. GFR was < 35 ml/min in 24 patients (18%). Ninety-four (18 M, 76 F) patients aged 71 [11] years transitioning to zoledronate were also studied.

Results

BMD improved following denosumab [mean (SEM) % change LS: 6.0 (0.62) p < 0.001, TH: 2.28 (0.64) p < 0.001, FN: 1.9 (0.77) p = 0.045]. Changes at the TH and FN were lower in patients with GFR < 35 ml/min (Group B) compared to those with GFR > 35 ml/min (Group A) [% change TH; Group A: 2.9 (0.72), Group B: − 0.84 (1.28), p = 0.015, FN; Group A: 2.76 (0.86), Group B: − 1.47 (1.53), p = 0.025]. % change in BMD at the FN and PTH were negatively associated (r = − 0.25, p = 0.013). BMD changes were not different at 12–18 months between patients on denosumab compared to zoledronate [% change at LS: denosumab: 3.97% (0.85), zoledronate: 2.6% (0.5), p = 0.19 TH: denosumab: 0.97% (0.58), zoledronate: 0.92% (0.6), p = 0.95).

Conclusion

Denosumab increases BMD following previous bisphosphonate treatment and is comparable to zoledronate. Lower response seen at the hip in CKD is related to PTH concentrations.
Understanding plagiarism in Indonesia from the lens of plagiarism policy: lessons for universities
Authors: Akbar Akbar , Picard Michelle
Published: October 2019

Plagiarism is viewed as a critical issue that can hinder the development of creativity and innovation in Indonesia. Thus, since the early 2000s the Indonesian government has endeavoured to develop policies to address this issue. In response to national policy, Indonesian educational institutions have made serious institutional efforts to address the plagiarism issue. Research in the Indonesian Higher education context on plagiarism has focussed on reporting prevention and mitigation efforts. However, little has been discussed about the communication of these efforts in policy across the different institutional levels of Indonesian Higher Education. This study aims at exploring the anti-plagiarism efforts by determining the main features (or discourses) reflected in plagiarism policy in Indonesian HE from national to institutional level. Two web-based resources namely the official website of The General Directorate of Research, Technology and Higher Education (retrieved 2015), and the website of Bandung Institute of Technology (retrieved 2015) were used to ascertain the most appropriate policies to include in the study. Critical Discourse Analysis (CDA) was used to reach explanatory understanding of how the policies (discursive events) demonstrate through their linguistic repetitions and other forms intertextuality, their relative positions within the Indonesian Higher Education institutional hierarchy and consequently provide some insight into the social practices and understandings of plagiarism underlying the creation of the documents. This study revealed that perhaps because of the rigid boundaries and hierarchies represented between the documents, the university policy does not show much transformation from the documents at a Ministry level, hence the definition of plagiarism remains broad and the levels of plagiarism and sanctions for plagiarism remain undefined. This can potentially lead to inconsistencies in developing effective practices preventing plagiarism.
Py3plex toolkit for visualization and analysis of multilayer networks
Authors: Škrlj Blaž , Kralj Jan , Lavrač Nada
Published: October 2019

Complex networks are used as means for representing multimodal, real-life systems. With increasing amounts of data that lead to large multilayer networks consisting of different node and edge types, that can also be subject to temporal change, there is an increasing need for versatile visualization and analysis software. This work presents a lightweight Python library, Py3plex, which focuses on the visualization and analysis of multilayer networks. The library implements a set of simple graphical primitives supporting intra- as well as inter-layer visualization. It also supports many common operations on multilayer networks, such as aggregation, slicing, indexing, traversal, and more. The paper also focuses on how node embeddings can be used to speed up contemporary (multilayer) layout computation. The library’s functionality is showcased on both real and synthetic networks.
Evaluation of host susceptibility, preference and offspring performance of Zeugodacus cucurbitae (Coquillett) (Diptera: Tephritidae) on different hosts
Authors: Farooq Muzammil , Baig Sangita , Honey Sabyan Faris , Bajwa Babar Ehsan , Fazlullah  , Shah Iqbal Hussain
Published: October 2019

The melon fruit fly, Zeugodacus cucurbitae (Coquillett) is a quarantine insect pest worldwide and affects the vegetable quality through its direct feeding and indirectly by passing way for secondary pathogens. This study investigated the host susceptibility, preference and offspring performance of Z. cucurbitae under the laboratory conditions. Different vegetable hosts i.e., brinjal (Solanum melongena L.), bitter gourd (Momordica charantia L.), zucchini (Cucurbita pepo L.), bottle gourd (Lagenaria siceraria [Molina] Standley) and cucumber (Cucumis sativus L.) were tested under no choice and free choice tests. Results showed that C. sativus and C. pepo have highest number of visits/host and oviposition puncture/host. C. sativus showed highest pupal recovery and pupal weight in both only choice and free choice test. While, highest percentage of emergence and female off springs were observed in C. pepo under only choice and free choice scenarios. Furthermore, maximum deformities in progeny were observed in case of L. siceraria under both test case scenarios. The current study provides exploratory support that fruit flies respond differently to host species that co-exists in field under choice and no choice test. Further, hosts of advantage to fruit flies are adopted more. The host and choice preference of fruit flies have the influence on the pest management strategies for the vegetable crops.
First there were 10: the case for and against South Sudan's new states using discourse analysis and argumentation theory
Authors: Tombe Sandra E.K.Y.
Published: October 2019

In 2015, South Sudan increased the number of its states from 10 to 28, followed by four more states in 2017. The redrawing of internal borders came through presidential decree as South Sudan's violent civil war continued to unfold. This development has led to two ardent voices: one arguing to maintain the new states, and another advocating to reverse them. Applying argumentation theory and critical discourse analysis to news articles, analysis pieces, and press releases collected fromGurtongandSudan Tribunefrom July 2015 to April 2017, this article assesses the argument advanced by both camps and evaluates their implications for peace in South Sudan. In examining the claim, the counter-claim, and their underlying premises, the article finds areas of contention and convergence between the two camps and argues for the compatibility of the values which undergird both positions.
Childhood maltreatment and suicide attempts in prisoners: a systematic meta-analytic review
Authors: Angelakis Ioannis , Austin Jennifer L. , Gooding Patricia
Published: October 2019

In the past decade, the links between core types of childhood maltreatment and suicidal acts have become an increasingly important area of investigation. However, no meta-analytic review has examined this relationship in prisoners. We undertook the first systematic meta-analytic review examining the link between childhood maltreatment and suicide attempts in prisoners to redress this important gap. We searched Medline, PsychINFO, Embase, Web of Science and CINAHL from inception until August 2019. Meta-analyses using random effect models were applied, and heterogeneity was quantified using the I2 statistic. Publication bias and risk of bias across studies were assessed. We identified 24 studies comprising 16 586 prisoners. The rates of different types of childhood maltreatment ranged between 29% and 68% [95% confidence interval (CI) 18–81%]. The rate of suicide attempts in prisoners was 23% (95% CI 18–27%). Main results demonstrated that sexual abuse [odds ratio (OR) 2.68, 95% CI 1.86–3.86], physical abuse (OR 2.16, 95% CI 1.60–2.91), emotional abuse (OR 2.70, 95% CI 1.92–3.79), emotional neglect (OR 2.29, 95% CI 1.69–3.10), physical neglect (OR 1.57, 95% CI 1.27–1.94) and combined abuse (OR 3.09, 95% CI 2.14–4.45) were strongly associated with suicide attempts in prisoners. There was an indication of publication bias. Duval and Tweedie's trim-and-fill method was applied, which increased the odds for suicide attempts. Given the high rates of prison suicide deaths and suicide attempts, our findings suggest an urgent need for targeted suicide prevention priorities for prisoners, with a particular focus on ameliorating the effects of childhood traumatic experiences on suicidal prisoners.
Expanding ‘religion’ or decentring the secular? Framing the frames in philosophy of religion
Authors: AMESBURY RICHARD
Published: October 2019

New cross-cultural approaches to philosophy of religion seek to move it beyond the preoccupations of Christian theology and the abstractions of ‘classical theism’, towards an appreciation of a broader range of religious phenomena. But if the concept ofreligionis itself the product of extrapolation from modern, Western, Christian understandings, disseminated through colonial encounter, does the new philosophy of religion simply reproduce the deficiencies of the old, under the guise of a universalizing, albeit culturally and historically particular, category? This article argues that it is necessary to interrogate the secular episteme within which religion is thematized as a discrete topos.
Understanding Default Behaviour in Workplace Pensions: Automatic Enrolment in the UK.
Authors: ROBERTSON-ROSE LYNNE
Published: October 2019

This article examines the retirement savings behaviour of twenty-five 30-40 years olds automatically enrolled into a workplace pension scheme. Using qualitative interviews, the paper explores the interaction between savings motivation and willingness to adhere to, or deviate from, the pension scheme defaults. Integrating insights from different savings paradigms, including sociological approaches and behavioural economics, the paper highlights how social motives drove willingness to accept enrolment defaults. Participants’ reactions to the contribution defaults were motivated by a complex combination of factors including anchoring effects, the salience of ageing, and emotional responses such as pride, uncertainty and loss aversion. The author’s main premise is that greater attention needs to be given to the interaction between subjective feelings about saving for retirement and pension scheme design.
Role of fiducial markers in the assessment of prostate bed motion in post-prostatectomy patients treated with volumetric modulated arc therapy
Authors: Vlachaki Maria T. , Ahmad Salahuddin , Kennedy Erika , Aref Amr M. , Chuba Paul J.
Published: October 2019

Aim:

Accurate localisation of target position is crucial when using techniques with sharp dose fall off such as volumetric modulated arc therapy (VMAT). Gold seed fiducial markers have been used for target localisation in image-guided radiation therapy for various tumors including intact prostate cancers. However, their role for target localisation in post-prostatectomy radiotherapy is unclear. This study was undertaken to determine the feasibility and effectiveness of gold seed fiducial markers in patients undergoing prostate bed VMAT.

Materials and methods:

The institutional radiation oncology database was used to analyse the treatment data of 18 post-prostatectomy patients with implanted gold seed fiducial markers. The shifts of the fiducial markers were reviewed, tabulated and statistically analysed.

Results:

Three hundred and eighty-six orthogonal pair images for 18 patients were reviewed. Specifically, the average gold seed fiducial shifts were 0·34 cm in the superior–inferior (S/I) axis (0·31 SD), 0·31 cm (0·29 SD) in the anterior–posterior (A/P) axis and 0·28 cm (0·25 SD) in the lateral axis (R/L). As a result, the 95% probability of fiducial marker displacement was 0·96 cm in the S/I, 0·89 cm in the A/P and 0·78 cm in the R/L axes. The most frequent shifts occurred in the inferior, left and posterior directions. The percentage of shifts more than 0·5 cm were 19·74, 21·56 and 12·47% for the S/I, A/P and R/L axes, respectively.

Conclusion:

In the absence of fiducial markers, non-uniform planning target volume (PTV) margins of 1 cm for S/I, 9 mm for A/P and 8 mm for the lateral direction are necessary for target localisation in post-prostatectomy radiotherapy. By improving prostate bed localisation, gold seed fiducial markers can decrease PTV margins, reduce normal tissue radiation exposure and allow for dose-escalated and/or hypofractionated radiotherapy to be considered in appropriate clinical scenarios.
GALOIS CONJUGATES OF SPECIAL POINTS AND SPECIAL SUBVARIETIES IN SHIMURA VARIETIES
Authors: Orr Martin
Published: October 2019

Let $S$ be a Shimura variety with reflex field $E$. We prove that the action of $\text{Gal}(\overline{\mathbb{Q}}/E)$ on $S$ maps special points to special points and special subvarieties to special subvarieties. Furthermore, the Galois conjugates of a special point all have the same complexity (as defined in the theory of unlikely intersections). These results follow from Milne and Shih’s construction of canonical models of Shimura varieties, based on a conjecture of Langlands which was proved by Borovoi and Milne.
Stellar chemo-kinematics of isolated dwarf spheroidal galaxies
Authors: Taibi S. , Battaglia G. , Rejkuba M. , Kacharov N. , Zoccali M.
Published: October 2019

The study of dwarf spheroidal galaxies (dSph) is of great importance to understand galaxy evolution at the low-mass end. In the Local Group the majority of them are found to be satellites of the Milky Way or M31. The closest ones have been studied in great detail, however it is hard to constrain if their present-day observed properties are mainly caused by internal or environmental mechanisms. In order to minimize these effects and gain an insight into their intrinsic properties, we are studying two of the three isolated dSph galaxies in the Local Group, i.e. Cetus and Tucana, located far beyond the virial radius of the Milky Way and M31. We present here results from our recently published analysis of Cetus (Taibi2018) and preliminary results for Tucana (Taibi et al. in prep.).
Catalog & atlas of the LV galaxies
Authors: Kaisina Elena I. , Karachentsev Igor D. , Makarov Dmitry I. , Kaisin Serafim S.
Published: October 2019

We present a database of galaxies in the Local Volume (LV) (https://www.sao.ru/lv/lvgdb/) Kaisina et al. (2012) having individual distance estimates within 11Â Mpc or corrected radial velocities VLG < 600 km s-1. It collects data on the following galaxy observables: angular diameters, apparent magnitudes in far-UV, B, and Ks bands, Hα and HI fluxes, morphological types, HI -line widths, radial velocities, and distance estimates. It also contains a consolidated set of optical images of all the galaxies from the SDSS and DSS surveys and Hα images of galaxies that were derived with the 6-m BTA telescope. The latest version of the Updated Nearby Galaxy Catalog (UNGC) Karachentsev et al. (2013) contains 869 objects, now the database consist of 1175 objects. We present basic relations, describing the updated LV sample: Hubble flow, distribution galaxies according to their distance estimates and on the sky, et al.
Synergies between Massive Stars and Metal-poor Dwarf Irregular Galaxies
Authors: Garcia Miriam , Herrero Artemio , Najarro Francisco , Castro Norberto , Camacho Inés
Published: October 2019

The community of massive stars is working intensively on Local Group dwarf irregular galaxies (dIrr). They are a reservoir of metal-poor massive stars that serve to understand the physics of their higher redshift siblings and population III stars, interpret the farthest, most energetic SNe and GRBs, and compute feedback through Cosmic History. Along the way, we became interested in the recent star-formation history and initial mass-function of the host dIrr’s, their chemical evolution, and gas and dust content. Our team is working to unveil and characterize with spectroscopy the OB-stars in IC 1613, Sextans A and SagDIG, that form a sequence of decreasing metal content. We showcase some results to stimulate synergies between both communities.
The hydrodynamic evolution of the gas content in the dSph galaxy Ursa Minor induced by the feedback from types Ia and II supernovae
Authors: Caproni Anderson , Lanfranchi Gustavo A. , Baião Gabriel H. Campos , Kowal Grzegorz , Falceta-Gonçalves Diego
Published: October 2019

Dwarf spheroidal galaxies of the Local Group share a similar characteristic nowadays: a low amount of gas in their interiors. In this work, we present results from a three-dimensional hydrodynamical simulation of the gas inside an object with similar characteristics of the Ursa Minor galaxy. We evolved the initial gas distribution over 3 Gyr, considering the effects of the types Ia and II supernovae. The instantaneous supernovae rates were derived from a chemical evolution model applied to spectroscopic data of the Ursa Minor galaxy. Our simulation shows that the amount of gas that is lost varies with time and galactocentric radius. The highest gas-loss rates occurred during the first 600 Myr of evolution. Our results also indicate that types Ia and II supernovae must be essential drivers of the gas loss in Ursa Minor galaxy (and probably in other similar dwarf galaxies).
A near-infrared VISTA of the Small Magellanic Cloud
Authors: Cioni Maria-Rosa L. , Niederhofer Florian , Rubele Stefano , Sun Ning-Chen
Published: October 2019

VISTA observed the Small Magellanic Cloud (SMC), as part of the VISTA survey of the Magellanic Clouds system (VMC), for six years (2010–2016). The acquired multi-epoch YJKs images have allowed us to probe the stellar populations to an exceptional level of detail across an unprecedented wide area in the near-infrared. This contribution highlights the most recent VMC results obtained on the SMC focusing, in particular, on the clustering of young stellar populations, on the proper motion of stars in the main body of the galaxy and on the spatial distribution of the star formation history.
Interstellar Medium and Star Formation in Dwarf Galaxies
Authors: Bolatto Alberto D.
Published: October 2019

This is a brief review of our understanding of the properties of the interstellar medium (ISM) in dwarf galaxies in connection to their star formation activity. What are the dominant phases of the ISM in these objects? How do the properties of these phases depend on the galaxy properties? What do we know about their cold gas content and its link to star formation activity? Does star formation proceed differently in these galaxies? How does star formation feedback operate in dwarf galaxies? The availability of observations from space-based facilities such as FUSE, Spitzer, Herschel, and Fermi, as well as observatories such as SOFIA and ALMA, is allowing us to make significant strides in our understanding of these questions.