bluuebunny/crossref_metadata_2025 huggingface dataset:
Characterization of the Intestinal Microbiota and Metabolites of Broiler Breeders with Different Egg Laying Rate
Authors: Yang Zengqiao , Wang Jianping , Celi Pietro , Zhang Keying , Ding Xuemei , Bai Shiping , Zeng Qiufeng , Mao Xiangbing , Feng Bing
Published: August 2019

BackgroundThe aim of the present study was to determine differences in the intestinal microbiota and metabolites of broiler breeders with different egg laying rate; and its possible relationships between intestinal microbiota and intestinal metabolites were also explored.MethodsA total of 200 AA+ parent broiler breeders (41-week-old) were separated into two groups according to their different egg laying rate: average reproductive group (AR: 77.26%±0.88%) and high reproductive group (HR: 86.67%±0.75%), with 10 replicates and 10 birds each 42-days study.ResultsFeed conversion ratio (FCR), ovary cell apoptosis rate (ApoCR) and abdominal fat pad weight percentage were lower (p < 0.05), while the hatchability of qualified egg rate (HQR) was higher (p < 0.05) in HR group than that in AR group. At phylum level, Firmicutes and Proteobacteria were the dominant bacteria in small intestines, while Bacteroidetes was dominant bacteria in cecum. At genus level, Lactobacillus was dominant in small intestines while Bacteroides were dominant in cecum. In HR Phascolarctobacterium were lower (p < 0.05) in ileum. A positive correlation was observed between Actinobacteria in the small intestines and ApoCR (r = 0.34 & p < 0.05). A positive correlation was observed between FCR and Spirochaetes in cecum (r = 0.54 & p < 0.05). The metabolomics analysis on ileal digesta content revealed a higher concentration of Octadecanoic acid, 9,12-Octadecadienoic acid, 11-trans-Octadecenoic acid, d-Ribose and Inositol in HR broiler breeders. Moreover, inositol was enriched in "Phosphatidylinositol signaling system", "Inositol phosphate metabolism", "Ascorbate and aldarate metabolism", "Galactose metabolism", "ABC transporters", and Octadecanoic acid was enriched in "Fatty acid biosynthesis", "Biosynthesis of unsaturated fatty acids".ConclusionsOur results suggest that glycerol, inositol modulate energy partitioning in fat metabolism to influence reproductive performances. Microbiota, such as Actinobacteria (phylum), Spirochaetes (phylum), and Phascolarctobacterium (genus) may have negative relationship with broiler breeders’ reproductive performances.
DNA methylation in blood - potential to provide new insights in immune cell biology
Authors: Macartney-Coxson Donia , Cameron Alanna , Clapham Jane , Benton Miles C
Published: August 2019

BackgroundEpigenetics plays a fundamental role in cellular development and differentiation; epigenetic mechanisms, such as DNA methylation, are involved in gene regulation and the exquisite nuance of expression changes seen in the journey from pluripotency to final differentiation. Thus, DNA methylation has the potential to reveal new insights in to immune cell biology.ResultsWe mined publicly available DNA methylation data with a machine-learning approach to identify differentially methylated loci between different white blood cell types. We then interrogated the DNA methylation and mRNA expression of candidate loci in CD4+, CD8+, CD14+, CD19+ and CD56+ fractions from 12 additional, independent healthy individuals (6 male, 6 female). ‘Classic’ immune cell markers such as CD8 and CD19 showed expected methylation/expression associations fitting with established dogma that hypermethylation is associated with the repression of gene expression. We also observed large differential methylation at loci which are not considered established immune cell markers, and some of these novel loci showed inverse correlations between methylation and mRNA expression (such as PARK2,DCP2).ConclusionsOur results highlight the value of mining publicly available data, the utility of DNA methylation as a discriminatory marker and the potential value of DNA methylation to provide additional insights into immune cell biology and developmental processes.
Risk Factors for Low Birth Weight among Neonates Delivered in Public Health Facilities in Adama town, Oromia Regional State, Ethiopia
Authors: Nebi Nigusse Obse , Chaka Tolossa Eticha , Abebe Tilaye Workineh , M Ephrem Mannekulih
Published: August 2019

Back ground: Low birth weight is the major predictor of prenatal mortality and morbidity world wide. It has been defined by the World Health Organization as weight at birth of less than 2,500 grams irrespective of their age. Rate of low birth weight is still high in developing countries like Ethiopia particularly Oromia regional state where adequate primary health care services for maternal and child health are not universally available to all the populations. It is therefore imperative to identify risk factors for low birth weight in various communities in order to come up with feasible intervention strategies to minimize the problem.
Methods: Facility based case-control study design was conducted from June-1/2017 to April-30/2018 on 318 mothers with singleton and full term neonates (108 case to 210 control). Semi structured interviewer administered and pretested questionnaire was used by trained data collectors working in delivery ward. The data were entered and analyzed statistical software. Descriptive and bivariate analysis was done.
Result
The mean maternal age of all study participants was 26.7 years with [SD of 4.8] with mean age for mothers of cases was 25.5 years and for controls was 27.4 years. In bivariet analysis residency being rural (AOR= 1.95 with 95% CI (1.0-3.48), parity ≥2 (AOR= 3.45 (1.89-6.32), number of antenatal care attendance ˂4 visits (AOR= 0.40(0.218-0.73)), birth interval ˂24 moths (AOR= 2.68 (1.45-4.94), history of hypertension (AOR= 0.39(0.18-0.87) and maternal MUAC ˂21cm (AOR=0.38 (0.159-0.91) were found to be statistically significant.
Conclusions
Variables that were found to have a statically significant relationship with low birth weight were residency being rural, occupation, parity ≥2 & birth interval ≤24months, number of antenatal care attendance ˂4 visits, history of hypertension and maternal MUAC ˂21cm were found to be statistically significant.
Key phrases:- Low bith weight, maternal risk factor
Two SNPs rs1801133 and rs1801394 in folate pathway are associated with the risk of nonsyndromic cleft lip with or without cleft palate
Authors: Li Qiuyan , Xu Lidan , Jia Xueyuan , Zaib Tahir , Sun Wenjing , Fu Songbin
Published: August 2019

Background Prenatal intake of folic acid is important for prevention of nonsyndromic cleft lip with or without cleft palate (NSCL/P), genes participant in folate pathway are crucial for preventing birth defects. The present study aims to investigate the associations between four single nucleotide polymorphisms (SNPs) in folate pathway genes and the risk of NSCL/P.
Methods Prediction by bioinformatics was conducted to assess the function of genetic variation. The PubMed, Embase database and Google Scholar were searched by two researchers to identify all relevant studies. Stata 11.0 software was used to calculate the results. Subgroup analysis was conducted to assess the influence of the genetic background. Sensitivity analysis, regression analysis and publication analysis were conducted to improve the strength of the results.
Results Two genetic variations rs1801394 in MTRR gene and rs1801133 in MTHFR were predicted damaging. A total of 34 publications were included in the present analysis. The results showed that there were a significant association between rs1801133 and NSCL/P risk in two genetic models TT allele vs CC allele (OR=1.333 95%CI=1.062-1.674, P=0.013) and recessive model (OR=1.325 95%CI=1.075-1.634, P=0.008) and there were a significant association between rs1801394 and NSCL/P risk in Asian (GG allele vs AA allele, OR=0.520 95%CI=0.321-0.841, P=0.008). Meta-regression, sensitivity analysis, and publication bias analysis confirmed that the results of the present study were statistically robust.
Conclusions This present study suggests that rs1801133 of the MTHFR gene and rs1801394 of the MTRR gene are risk factors for NSCL/P. Additional, larger studies should be performed to confirm these findings.
Obesity is potentially associated with a novel mitochondrial tRNAGly 10029A>G mutation in a Chinese family
Authors: Wang Jinling , Zhao Ningning , Mao Xiaoting , Meng Feilong , Huang Ke , Dong Guanping , Ji Yanchun , Fu JunFen
Published: August 2019

Background

Obesity is one of the most prominent public health challenges globally. Mutations in mitochondrial genes can similarly lead to the onset of childhood obesity remains unclear.

Methods

we conducted a clinical, genetic, and molecular profiling of a Han Chinese family with evident of matrilineally-inherited obesity. Obesity was evident in 2/6 matrilineal relatives in a single generation of this family (of 3 available generations). When the mitochondrial DNA of these individuals was sequences and a pedigree analysis was performed.

Results

We were able to identify a novel homoplasmic mutation of the mitochondrial tRNAGly gene (10029A>G) in these individuals. This mutation was linked to destabilization of a conserved base pair in the anticodon of this tRNA. This position (position 43) is known to be important for mediating effective codon recognition and tRNA stability. Consistent with the importance of this conserved site, we found that the predicted structure of a tRNAGly structure bearing a 10029A>G mutation was markedly altered in a molecular dynamics simulation relative to the wild-type isoform. All other mutations identified in the mtDNA of this individual were known variants associated with Asian haplogroup D4.

Conclusion

Our report provides novel evidence of a link between a tRNA mutation and an elevated risk of maternally-transmissible obesity risk, offering potentially novel insights into the underlying nature of obesity.
Characterizing a focused landscape of familial acute respiratory distress syndrome
Authors: Toby Inimary , Thomas Neal , Thorenoor Nithyananda , Spear Debbie , DiAngelo Susan , Floros Joanna
Published: August 2019

Background Acute respiratory distress syndrome (ARDS) affects approximately 190,600 patients per year in the United States, with mortality up to 45%. ARDS can occur as primary disease due to various factors (e.g. bacterial or viral pneumonia, gastric aspiration, lung contusion, toxic inhalation, and near drowning) or as secondary disease due to sepsis, pancreatitis, severe trauma, massive blood transfusion, and burn. We hypothesized that ARDS-affected individuals have patterns of variants in their physiological repertoire that can be tracked and utilized to complement clinical diagnosis and/or clinical monitoring. Methods The goals of this study were to: (1) characterize the landscape of variants within protein coding but we also studied UTR regions in ARDS using an Exome sequencing approach; (2), determine the variations in signaling pathways across ARDS; and (3) use computational approaches to explore the functional consequences of ARDS. Towards this we assessed an ARDS-affected individual in the context of unaffected individuals from the same family as well as unrelated ARDS cases, in order to elucidate underlying inheritance patterns of “private variants”. Private variants consist of variants shared by ARDS cases but not found in unaffected individuals. Results Whole exome sequencing yielded 3,516 variants represented by 2,354 genes. Of these, 128 variants were shared across all ARDS cases. Of these, there were 24 unique variants represented by 9 ARDS genes shared by the primary ARDS-case and unrelated individuals with ARDS. The overall genes identified and subsequent analysis, demonstrate that there are important biological pathways that distinguish ARDS cases from or from non-ARDS. These pathways include: cell-to-cell signaling interaction, cell growth and proliferation and cell morphology. The data also show a coordinated effort amongst biological processes such as liver hyperproliferation and cell death that underlie the pathogenesis of ARDS. Conclusions These in-silico discoveries demonstrate a role for private variants shared by ARDS cases to be leveraged as biomarkers for clinical diagnosis and/or monitoring of ARDS.
Pilot study of expanded newborn screening for 573 genes related to severe diseases in China: results from 1173 newborns
Authors: Luo Xiaomei , Sun Yu , Xu Feng , Guo Jun , Li Lin , Lin Zhiwei , Ye Jun , Gu Xuefan , Yu Yongguo
Published: August 2019

Background: Current newborn screening (NBS) in China is mainly aimed at detecting biochemical levels of metabolites in blood, which may generate false positive/negative results. Methods: We designed a next-generation sequencing (NGS) panel of 573 genes related to severe diseases and performed NBS for 1173 individuals, who had been screened for tandem mass spectrometry (MS/MS), phenylalanine (Phe), thyroid-stimulating hormone (TSH), 17-α-hydroxyprogesterone (17-OHP) and glucose-6-phosphate dehydrogenase (G6PD) as conducted in traditional biochemical NBS in September 2016. We compared their biochemical results with genetic variants and investigated the carrier frequencies of 77 genes related to disorders of MS/MS in these newborns. Results: Biochemical results showed that four newborns were positive for G6PD enzymatic assay (all males), the other biochemical values including MS/MS, Phe, TSH and 17-OHP were negative. Genetic analysis results showed that all the four newborns with positive G6PD values carried G6PD hemizygous mutations. Besides, NGS results revealed an individual (ID 84123) carrying two common SLC22A5 mutations (c.760C>T/p.R254* and c.1400C>G/p.S467C) in Chinese population which were verified in trans later, was biochemical negative in 2016. MS/MS results in June 2019 showed free carnitine deficiency, which was consistence with genetic analysis results. Carrier frequencies data suggested the top five genes with the highest carrier frequencies in these newborns were PAH (2.04%), ETFDH (1.24%), MMACHC (1.15%), SLC25A13 (0.98%), and GCDH (0.80%). Conclusion: Our study provides data that combine biochemical results with genetic variants in 1173 newborns. This is the first study that reveals carrier frequencies of 77 genes causing inherited metabolic diseases (IMDs) in China.
Large-scale sequencing combined with bioinformatics analysis reveals KLF8 an apoptosis repressor in hepatocellular carcinoma
Authors: Xing Hao , Zhang Jin , Zheng Kai-Lian , Wang Ming-Da , Han Jun , Li Chao , Li Zhen-Li , Wu Han , Liang Lei , Wu Meng-Chao , Shen Feng , Yang Tian
Published: August 2019

Backgrounds Hepatocellular carcinoma (HCC) is the most frequent primary liver cancer and the third leading cause of cancer death. Krüppel-like factor 8 (KLF8) is an oncogene and has been shown playing an important role in HCC, but the major involved signaling pathways are still unknown. Here, we systematically analyzed the role of KLF8 in HCC using RNA sequencing and the anti-H3K27 acetylation ChIP sequencing combined with bioinformatics analysis, and the results of data mining. Results The results in this study showed that KLF8 worked as a transcription repressor in HCC and the main directly regulated ones were apoptosis-related genes. Furthermore, we verified the combination of KLF8 with some predicted target genes by ChIP, which supported the effectiveness of our analysis. Besides, we demonstrated that HMGA2 and MMP7, two predicted targets, were important participants in KLF8 mediated anti-apoptotic effect in HCC. Conclusions Our work offers a panoramic view of KLF8’s role in HCC for the first time and facilitates the discovery of new targets for HCC via KLF8.
Evaluation of the bacterial frequency causing ventilator associated pneumonia(VAP) in patients admitted in internal ICUs and internal wards at Shiraz Teaching Hospitals
Authors: Khalili Tahereh , Samadi Nasser , Abadi Milad Shahini Shams , Panah Mohammad Ali Davar , Motamedifar Mohammad , Hadi Nahal
Published: August 2019

Objective

Ventilator associated pneumonia (VAP), which is a subset of hospital infections, occurs in patients who have been mechanically ventilated for at least 48 hours. The aim of this study was to determine the frequency of bacteria causing VAP and determine their antimicrobial susceptibility pattern.Results

The present study is a cross-sectional descriptive study which was conducted in Shiraz during the 8 months (from November 2017 till June 2018). Samples were identified according to the diagnostic tests of bacteriology and antibiotic susceptibility test was performed using CLSI standards. 51 patients with VAP were examined, of which 10 and 8 patient respectively had chronic obstructive pulmonary disease and acute respiratory distress syndrome. The late onset VAP (61.7%) rate was more than compared to the early onset VAP rate (38.3%). The most frequently used antibiotics were meropenem (76.6%) and vancomycin (78.7%). Among 59 bacteria were isolated, Acinetobacter and Pseudomonas were the most prevalent organisms. Our data showed that most of the isolates (40%) belonged to Multi Drug Resistant (MDR) pathogens.
Assessment of knowledge towards breast cancer early detection methods among female health professionals in Adigrat town public health institutions, Tigray, northern Ethiopia, 2018
Authors: Aynalem Amdehiwot , Mebratu Andualem
Published: August 2019

Objective The main objective of the study to determine breast cancer early detection method knowledge among female health professional, Adigrat, town, Tigray, Ethiopia, 2018.Result The study assessed the knowledge of health professionals. Majority of the health professionals 55.7% (60) were founded knowledgeable and 44.3% (48) were not knowledgeable.
ANALYTICAL COMPARISON BETWEEN SPECTROPHOTOMETER AND PORTABLE GLUCOMETER FOR MEASUREMENT OF BLOOD GLUCOSE IN HORSE
Authors: Jima Nanoshe Taye , Megerssa Yoseph Cherinet
Published: August 2019

Objective: Analytical methods comparison for the determination of blood glucose are essential in clinical laboratory practice as it improves the quality of health care through accurate and reliable clinical decision making. Therefore The study was done to assess the analytical performance between point-of-care glucometer and spectrophotometric methods for blood glucose determination.
Results: Twenty paired samples from horses visiting SPANA clinic of college of veterinary medicine and agriculture Addis Ababa University was used. Data obtained from both instruments was compared. The results shows that the mean value of blood glucose concentrations were higher in by the glucometric method (106mg/dl) than by the spectrophotometric (73mg/dl) with the calculated t-statistic significantly different p-value of 0.000. This study showed the clinical inaccuracy of the glucometer over the spectrophotometer.
Influence of Soda Content on Desiccation Cracks in Clayey Soils
Authors: Yang Binbin , Yuan Junhong
Published: August 2019

Alkaline clayey soil is considered to be a degraded soil, which causes serious issues in engineering and construction projects. The formation and development of desiccation cracks in alkaline clayey soils is a complex process affecting the strength, stability, and permeability of these soils. Therefore, to investigate how soda content can inhibit the development of desiccation cracks in alkaline clayey soils in Ulanhot, Inner Mongolia, China, free desiccation tests were performed to examine the cracks in alkaline clayey soil samples with different soda (Na2CO3) contents in the laboratory. During the cracking process, the changes in water content and the occurrence and evolution of cracks were recorded with a camera. Digital image processing was performed to analyze the structure characteristics of the surface cracks. The results indicated that the characteristics are influenced by the different soda contents. The soda inhibited the development of desiccation cracks in alkaline clayey soils. Three stages were found in the process of desiccation cracking in accordance with the rate of water loss: the residual, normal, and structural shrinkage stages. At <0.4 mol L−1 Na2CO3, the “three straight lines” model could be used to describe the volume shrinkage. However, at >0.4 mol L−1 Na2CO3, the structural shrinkage stage disappeared. Moreover, based on the general soil volume change equation and fractal theory, a model was formulated to quantitatively explain the relationship between the fractal dimension and the volume changes in the soil. The experimental results and equations are important for reducing subgrade deformation and slumps.

Core Ideas

Soda content can inhibit the development of desiccation cracks in clayey soils.

There are three stages in the process of desiccation cracking in alkaline clayey soil.

A model is formulated to explain the fractal dimension and the volume changes in the alkaline clayey soil.

The structural shrinkage stage will disappear when Na2CO3 is >0.4 mol L−1.
Secure Information Flow for IoT Applications
Authors: Ngo Tri Minh , Nguyen-Duy-Nhat Vien
Published: August 2019

This paper discusses how to ensure security, i.e., confidentiality and integrity properties, for data in IoT applications. While confidentiality could be assessed via information flow analysis, integrity is ensured by error-correcting codes. In addition to errors, many communication channels also cause erasures, i.e., the demodulator cannot decide which symbol the received waveform represents. The paper proposes a method that might correct both errors and erasures together. Our method is efficient in reducing memory storage as well as decoding complexity.
Pemikiran Abdullah Ahmed An-Naim tentang Dekontruksi Syari’ah sebagai Sebuah Solusi
Authors: Taufiq Ahmad
Published: August 2019

The laws contained in the Qur'an still exist that require interpretation and have the potential to develop. Muslims worldwide may be entitled to apply Islamic law, provided it does not violate the rights of other people and groups, both within and outside of the Islamic community. That is, in claiming and using individual and collective rights to self-determination, Muslims must also recognize and guarantee equal rights for others. Abdullah, descriptive-analytical nature. Ahmed An-Naim to answer the gap between shari'ah and issues of modernity . Shari'a decontructions are used for Islamic legal issues using the Knife of Analysis used first by Mahmud Thaha's Theory of Law Evolution, the second nasikh mansukh theory, the third  Makiyyah and Madaniyah, the fourth the interpretation of the gender-based text, the fifth concept of shari'a on human rights
Tradisi Keagamaan dan Proses Sosial pada Kaum Muslim Pedesaan
Authors: Riyadi Agus
Published: August 2019

Religious ceremonies that are usually carried out by Javanese are inherited from the ancestors. There are two types of religious ceremonies in the form of salvation in Javanese society, namely life cycle salvation ceremonies and Islamic religious holidays. The research aims to find an understanding of the traditions of religious ceremonies and social processes for Muslims in Karangrayung District, Grobogan Regency. Data collection methods were obtained through observation, interviews, documentation and literature study. After that, the data is analyzed qualitatively-descriptive-interpretative. The results showed that there were seven religious ceremonies and social processes which until now were still commemorated by the Karangrayung people, namely: Sura (Muharam), Rajaban selametan, Mauludan selametan, Selametan Ruwahan, Selametan Likuran, Selametan Bodonan, and Selametan Besar which were held on the 10th Zulhijjah. The perception of the people of Karangrayung on religious ceremonies and social processes is a form of virtue that is recommended by Islamic teachings that contain values: 1) charity, 2) ukhwah Islamiyah, 3) help, and 4) share with others
Análisis de las compras de los consumidores mexicanos en Estados Unidos basado en el gasto de hogares
Authors: Díaz González Eliseo , González-König Gabriel
Published: August 2019

El objetivo del estudio es analizar los determinantes de realizar compras transfronterizas por los mexicanos en el mercado de Estados Unidos; basados en microdatos, en modelos de elección de consumidor y competencia fiscal, se busca probar la hipótesis según la cual el incentivo para que los consumidores crucen la frontera es una función inversa a la distancia. Se concluye que la localización de los consumidores en los estados fronterizos y de tradición migratoria son determinantes de las compras transfronterizas, suponiendo consumidores racionales y dadas diferencias de precios y de impuestos al consumo entre ambos países.
Enfrentamento de repercussões físicas e psicossociais em mulheres vítimas de violência através da consciência corporal: Experiência da fisioterapia
Authors: Lima Clara Taína Silva , Correia Melina Baquit , Rebouças Nahra Santos , Carvalho Priscylla Oliveira de , Ferreira Rebeca Monteiro , Vasconcelos Thiago Brasileiro de , Santos Mayara Paz Albino dos , Macena Raimunda Hermelinda Maia
Published: August 2019

Conscientização; Dor; Mulheres vítimas de abuso; Fisioterapia.
Direito à informação em saúde na sociedade midiatizada
Authors: Emerich Tatiana Breder , Oliveira Adauto Emmerich
Published: August 2019

Editorial
O aleitamento materno e sua relação com a prevenção das oclusopatias
Authors: Moimaz Suzely Adas Saliba , Rocha Najara Barbosa da , Garbin Artênio José Isper , Saliba Orlando
Published: August 2019

Aleitamento materno, Má oclusão, Saúde bucal
Opinião dos graduandos em odontologia diante da estratégia de saúde da família
Authors: Padovani Maria Cristina Ramos Lima , Barbosa Patrícia da Silva , Santos Maria Teresa Botti Rodrigues dos , Araki Ângela Toshi , Prokopowishch Igor , Sant’Anna Giselle Rodrigues
Published: August 2019

Saúde da família, Currículo, Saúde bucal
Automedicação entre acadêmicos do curso de Medicina da Faculdade de Medicina de Marília, São Paulo
Authors: Masson Wallan , Furtado Poliana Lempk , Lazarini Carlos Alberto , Conterno Lucieni de Oliveira
Published: August 2019

Automedicação, Estudantes de Medicina, Prevalência
Desmistificando a biossegurança: a importância do correto uso do termo
Authors: Nati Tassia , Bravim Fernanda , Fernandes Antonio Alberto Ribeiro , Fernandes Patricia Machado Bueno
Published: August 2019

Biossegurança, Biosseguridade, Segurança biológica, Biotecnologia
Uso da biotecnologia para a melhoria da qualidade nutricional de alimentos
Authors: Santos Alan Costa Sarcineli , Fernandes Antonio Alberto Ribeiro , Fernandes Patricia Machado Bueno
Published: August 2019

Alimento geneticamente modificado, Nutracêuticos, Segurança alimentar
Boas práticas e qualidade microbiológica nos serviços de alimentação escolar: uma revisão sistemática
Authors: Cunha Diogo Thimoteo da , Stedefeldt Elke , Rosso Veridiana Vera de
Published: August 2019

Alimentação escolar, Manipulação de alimentos, Microbiologia de alimentos, Higiene dos alimentos
Influência do pré-aquecimento e do croma da resina composta em suas propriedades de sorção e solubilidade
Authors: Mello Mariana Miranda , Castro Fabrício Luscino Alves de , Reges Rogério Vieira
Published: August 2019

Resinas compostas; Temperatura alta; Solubilidade
Qualidade de vida de cirurgiões-dentistas que atuam no serviço público
Authors: Rovida Tânia Adas Saliba , Saliba Nemre Adas , Lima Daniela Pereira , Garbin Cléa Adas Saliba , Moimaz Suzely Adas Saliba
Published: August 2019

Qualidade de vida; Odontólogos; Organização Mundial da Saúde.
Resposta ao teste tuberculínico entre estudantes de Enfermagem de Londrina, Paraná
Authors: Dessunti Elma Mathias , Meier Denise Andrade Pereira , Costa Arlete Alves Nunes Fragoso da , Souza Klayton Rodrigues de , Lopes Gilselena Kerbauy
Published: August 2019

Teste tuberculínico; Tuberculose; Biossegurança; Estudantesde Enfermagem.
Análise do selamento da fita de politetrafluoretileno com adição de clorexidina a 2% em relação à microinfiltração de Escherichia coliem implantes dentários
Authors: Daros Gisele Felicetti , Zago Camila D’Acampora Reis , Degenhardt Roberto , Zaions Maria Ignez Marchioro
Published: August 2019

Clorexidina; Implante dentário; Politetrafluoretileno.
Ocorrência de alterações dermatológicas e vasculares em gestantes de uma Unidade Básica de Saúde de Campina Grande, PB
Authors: Passos Anna Ferla Monteiro Silva , Nobrega Jullyana Mayara dos Santos Silva , Costa Íris do Céu Clara
Published: August 2019

Gravidez; Dermatologia; Saúde da mulher.
Manejo do aleitamento materno: ações de enfermeiros das equipes de Estratégias de Saúde da Família de um município do norte do Espírito Santo
Authors: Santos Ludmilla Gripa Barcellos dos , Nascimento Luciana de Cássia Nunes , Leite Franciele Marabotti Costa , Moser Denise Consuelo
Published: August 2019

Aleitamento Materno; Enfermagem em Saúde Comunitária; Saúde da Criança; Enfermagem.
Odontologia hospitalar nos hospitais de grande porte da região metropolitana da Grande Vitória, Espírito Santo
Authors: Gonçalves Camila Lopes , Silva Junior Manoelito Ferreira , Andrade Lezimara Santiago de , Miclos Paula Vitali , Gomes Maria José
Published: August 2019

Unidade hospitalar de Odontologia; Equipe hospitalar de Odontologia; Comunicação interdisciplinar; Área de atuação profissional.
Potencial antifúngico da Punica granatum Linn na odontologia
Authors: Santos Manuela Gouvêa Campêlo dos , Pereira Jozinete Vieira , Nóbrega Danubia Roberta de Medeiros
Published: August 2019

Punicaceae; Candida albicans; Fitoterapia.
O IX Congresso Brasileiro de Epidemiologia, a ABRASCO JOVEM e a Revista Brasileira de Pesquisa em Saúde
Authors: Theodoro dos Santos Neto Edson
Published: August 2019

Editorial
Prevalência de asma, rinite e eczema atópico em escolares do município de Vitória, Espirito Santo, Brasil
Authors: Serpa Faradiba Sarquis , Zandonade Eliana , Reis Juliana Lacerda , Borja Tatiane Neves , Moyses Therezinha , Campinhos Fernanda Lugão , Braga Neto Firmino , Chiabai Joseane
Published: August 2019

Asma; Rinite alérgica perene; Dermatite atópica; Criança; Epidemiologia.
Relação entre hábitos de higiene bucal, utilização de serviços odontológicos, variáveis sociodemográficas e estilo de vida de servidores de uma universidade pública do Brasil
Authors: Barroso Ana Dilza Viana , Batista Rafaela das Mercês , Oliveira Adauto Emmerich , Santos Neto Edson Theodoro dos , Zandonade Eliana
Published: August 2019

Hábitos; Saúde bucal; Higiene bucal; Serviços de Saúde Bucal.
Caracterização sociodemográfica e epidemiológica dos doadores de córneas do banco de tecidos oculares do Rio Grande do Norte
Authors: Silva Micheline da Fonseca , Gomes Andréa Tayse de Lima , Freire Izaura Luzia Silvério , Dantas Bruno Araújo da Silva , Torres Gilson de Vasconcelos
Published: August 2019

Morte encefálica; Bancos de tecidos; Doadores de tecidos; Transplante de córnea; Enfermagem.
Consumo de frutas, vegetais, óleos e gorduras e nível de atividade física em população portadora de hipertensão arterial e/ou diabetes mellitus adscrita à Estratégia de Saúde da Família em Salvador, Bahia
Authors: Luna Julia Lange , Luz Leandro Alves da , Vilasbôas Ana Luiza Queiroz , Pamponet Marina Luna , Medina Maria Guadalupe , Aquino Rosana , Fonseca Ana Carla
Published: August 2019

Comportamento alimentar; Atividade motora; Hipertensão; Diabetes mellitus; Saúde da família.
Consumo de sódio e potássio por diferentes métodos de avaliação: uma revisão em estudos populacionais
Authors: Porto Aline Silva , Pereira Taísa Sabrina Silva , Molina Maria del Carmen Bisi
Published: August 2019

Hipertensão; Sódio; Potássio; Métodos.
Prevalência de cárie, dor e uso de serviços odontológicos por crianças em áreas com e sem Equipes de Saúde Bucal na Estratégia Saúde da Família no município de Ponta Grossa, Paraná, Brasil
Authors: Hamati Felipe , Rocha Juliana Schaia , Baldani Márcia Helena
Published: August 2019

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Qualidade da assistência no Centro de Atenção Psicossocial: perspectiva de familiares
Authors: Azevedo Dulcian Medeiros de , Oliveira Andrêza Maria de , Freitas Camylla Cavalcante Soares de , Araújo Rhayssa de Oliveira e , Melo Gabriela de Sousa Martins , Torres Gilson de Vasconcelos
Published: August 2019

Avaliação de serviços de saúde; Serviços de saúde mental; Família; Saúde Mental.
Do conhecimento à ação: o enfoque da Ecossaúde no contexto da dengue a partir de uma experiência de educação popular
Authors: Matos Adriana Ponte Carneiro de , Motta Cyntia Monteiro Vasconcelos , Caprara Andrea , Sousa Rosilea Alves de
Published: August 2019

Saúde ambiental; Dengue; Ecologia.
Hypomagnesemia in Obese Subjects: Evidence of Systematic Review and Meta-analysis
Authors: Cruz Kyria J.C. , de Oliveira Ana R.S. , de Freitas Suelem T. , Henriques Gilberto S. , do Nascimento Marreiro Dilina
Published: August 2019

Background::

Magnesium deficiency is a global nutritional problem which seems to influence
obesity-associated metabolic disorders because magnesium plays an important role in the prevention
and treatment of many diseases.

Objective::

We conducted a systematic review and meta-analysis to evaluate the relationship between
plasma magnesium concentrations and obesity.

Methods::

A systematic review and meta-analysis of case-control studies was conducted. Relevant
studies were identified from a literature search using electronic databases.

Results::

Ten case-control studies were evaluated in this meta-analysis. Results demonstrated that
obese individuals presented lower plasma magnesium concentration than healthy individuals (standardized
mean difference [SMD] = -0.44, 95% confidence interval = -0.88 to -0.01). In subgroup
analyses, there were differences in plasma magnesium concentration between obese and healthy individuals
according to study location, gender, case age, control age, method for assessment of magnesium
concentration and study quality. Furthermore, meta-regression analyses showed that the
source of heterogeneity of magnesium levels among studies was control age.

Conclusion::

Evidence of this systematic review and meta-analysis show hypomagnesemia in obese
individuals of both genders.
Heart Failure and Cognitive Impairment: Clinical Relevance and Therapeutic Considerations
Authors: Mene-Afejuku Tuoyo O. , Pernia Monica , Ibebuogu Uzoma N. , Chaudhari Shobhana , Mushiyev Savi , Visco Ferdinand , Pekler Gerald
Published: August 2019

:

Heart failure (HF) is a devastating condition characterized by poor quality of life, numerous complications, high rate of readmission and increased mortality. HF is the most common cause of hospitalization in the United States especially among people over the age of 64 years. The number of people grappling with the ill effects of HF is on the rise as the number of people living to an old age is also on the increase.

:

Several factors have been attributed to these high readmission and mortality rates among which are; poor adherence with therapy, inability to keep up with clinic appointments and even failure to recognize early symptoms of HF deterioration which may be a result of cognitive impairment.

:

Therefore, this review seeks to compile the most recent information about the links between HF and dementia or cognitive impairment. We also assessed the prognostic consequences of cognitive impairment complicating HF, therapeutic strategies among patients with HF and focus on future areas of research that would reduce the prevalence of cognitive impairment, reduce its severity and also ameliorate the effect of cognitive impairment coexisting with HF.
Correlation between Antioxidant/Antimutagenic and Antiproliferative Activity of Some Phytochemicals
Authors: Ramadan Doaa T. , Ali Mohamed A.M. , Yahya Shaymaa M. , El-Sayed Wael M.
Published: August 2019

Background:

Chemotherapeutic drugs have high toxicity associated with undesirable side-effects. Now,
natural products are the most important anti-cancer agents because of their low toxicity and potential effectiveness.

Methods:

The half maximal inhibitory concentration (IC50) of amygdalin, naringenin and ellagic acid against
breast, colon, and liver cell lines was estimated. The antimutagenic, free radical-, superoxide radical-, and hydroxyl
radical- scavenging activities of these phytochemicals were measured. The expression of p53, bid, bax,
bcl2, and caspases 9, 3, and 7 was measured by quantitative real-time polymerase chain reaction (qRT-PCR) in
breast and liver cells. In addition, the active Caspase 3 protein was estimated in liver cells.

Results:

Ellagic acid showed the highest antioxidant and antiproliferative activities. Amygdalin and naringenin
with low and moderate antioxidant profiles showed a corresponding low and moderate cytotoxicity against
cancer cell lines, respectively. Naringenin and ellagic acid had a significant antimutagenic activity which was
detected by the Salmonella test. Ellagic acid offered a much better antimutagenic activity than naringenin. The
apoptotic pathway evoked by ellagic acid in HepG2 and MCF-7 cells was investigated. The results showed that
a caspase-dependent and a caspase-independent apoptosis occurred in MCF-7 and HepG2, respectively.

Conclusion:

The antimutagenic/antioxidant properties are well correlated with the antiproliferative activity of
the phytochemicals investigated. This study proved that some easy, quick and cheap assays could predict the
antiproliferative activity of many nutraceuticals. Finally, this platform could help in the discovery of new anticancer
agents where hundreds of compounds are investigated in the pipeline of drug discovery.
Evaluation of Pb (II) Adsorption from Aqueous Solutions Using Brassica nigra as a Biosorbent
Authors: Reátegui-Romero Warren , Cadenas-Vásquez Walter J. , King-Santos María E. , Alvarez Walter F. Zaldivar , Posadas Ricardo A. Y.
Published: August 2019

Objectives:

The Pb non-biodegradability results in bioaccumulation in living organisms causing serious health disorders. The present study aimed to investigate the capacity of Pb (II) adsorption in aqueous solutions using theBrassica nigraspecies as biosorbent.

Methods:

The present study was conducted using a synthetic solution with three Pb (II) concentrations (5, 15, and 30 ppm). TheB. nigrawas suitably treated until it became dry particles. After sifting it, three ranges of grain sizes were obtained. Samples of dry particles were analyzed before and after the biosorption to analyze their topography (SEM), as well as the elements on their surface (EDS). The influence of different operating variables on the biosorption of Pb (II) were analyzed. Kinetics of Pb (II) biosorption was analyzed with pseudo first and second order models. The biosorption in the equilibrium was studied with the Langmuir isotherm and Freundlich isotherm models.

Results:

The biosorbentB. nigrashowed to be efficient for the adsorption of Pb (II). The most influential variables in the adsorption were pH, particle size, and biosorbent/solution ratio. The optimum pH for the adsorption of lead was 5 and removed 82.10% of lead from solution at 5 ppm, 82.24% at 15 ppm and 57.95% at 30 ppm. The results for the particle size between 177 and 297 μm were 82.65% for 5 ppm, 73.71% for 15 ppm, and 53.54% for 30 ppm. The biosorbent/solution ratio of 0.6 mg/mL or the 30 mg dose of biosorbent removed 80.26% for 5 ppm, 79.32% for 15 ppm, and 59.87% for 30 ppm. Biosorption isothermal data could be well interpreted by the Langmuir model with a maximum adsorption capacity of 53.476 mg/g of lead ion onB. nigrastem and roots biomass. The kinetic experimental data was properly correlated with the second-order kinetic model (R2= 0.9997). Thus, the best desorbing agent was HNO3(0.1N) for Pb (II) desorption.

Conclusion:

Our study showed that the herbB. nigra, without any chemical treatment, can be used to remove heavy metals such as Pb (II) from water and aqueous solution.
Evaluation of the Anti-Tumor Activity of Niclosamide Nanoliposomes Against Colon Carcinoma
Authors: Hatamipour Mahdi , Jaafari Mahmoud R. , Momtazi-Borojeni Amir A. , Ramezani Mahin , Sahebkar Amirhossein
Published: August 2019

Background and Aims:

Niclosamide is an established anti-helminthic drug, which has recently
been shown to inhibit the growth of various cancer cells. To exploit the potential anti-tumor activity
of this drug for systemic use, the problem of low aqueous solubility should be addressed. The
present study tested the in vivo anti-tumor effects of a recently developed nanoliposomal preparation of
niclosamide in an experimental model of colon carcinoma.

Methods :

The cytotoxicity of nanoliposomal niclosamide on CT26 colon carcinoma cells was evaluated
using the MTT test. Inhibition of tumor growth was investigated in BALB/c mice bearing CT26 colon
carcinoma cells. The animals were randomly divided into 4 groups including: 1) untreated control, 2)
liposomal doxorubicin (15 mg/kg; single intravenous dose), 3) liposomal niclosamide (1 mg/kg/twice a
week; intravenously for 4 weeks), and 4) free niclosamide (1 mg/kg/twice a week; intravenously for 4
weeks). To study therapeutic efficacy, tumor size and survival were monitored in 2-day intervals for 40
days.

Results:

In vitro results indicated that nanoliposomal and free niclosamide could exert cytotoxic effects
with IC50 values of 4.5 and 2.5 μM, respectively. According to in vivo studies, nanoliposomal niclosamide
showed a higher growth inhibitory activity against CT26 colon carcinoma cells compared
with free niclosamide as revealed by delayed tumor growth and prolongation of survival.

Conclusion :

Nnaoliposomal encapsulation enhanced anti-tumor properties of niclosamide in an experimental
model of colon carcinoma.
The Effects of Lead of an Environmental Toxic Heavy Metal on Fetus Health
Authors: GÜRGEN ŞİMŞEK Hatice , ÖNAL Ayşe Emel
Published: August 2019

Lead, which is widely
found in the environment and used in many industrial areas, poses a risk to
human health. In the evaluation of fetal lead effects, maternal blood lead
level and cord blood lead levels are widely used. It may cause negative health
consequences on fetus as a result of various ways of getting, storing and
reaching the fetus through the placenta in pregnancy. In order to reduce lead
levels in the blood, nutrition is primarily important during pregnancy. Health
workers, especially public health professionals, have an important role in
reducing the negative effects of blood lead levels during pregnancy.Çevrede yaygın bir şekilde bulunan ve birçok
endüstriyel alanda kullanılan kurşun, insan sağlığı için risk teşkil
etmektedir. Fetal kurşun etkileniminin değerlendirilmesinde, anne kan kurşun
düzeyi ve kord kanı kurşun düzeyleri yaygın bir şekilde kullanılmaktadır.
Vücuda değişik yollarla alınması, depolanması ve gebelikte plasenta
aracılığıyla fetüse ulaşması sonucu, fetüs üzerinde olumsuz sağlık sonuçlarına
neden olabilmektedir. Kanda kurşun seviyelerinin azaltılması için gebelik
döneminde öncelikli olarak beslenme önem arz etmektedir. Gebelikte, kan kurşun
düzeylerinin olumsuz etkilerinin azaltılması konusunda, sağlık çalışanlarına,
özellikle halk sağlıkçılara önemli görevler düşmektedir.
Home Virtual Visits for Outpatient Follow-Up Stroke Care: Cross-Sectional Study
Authors: Appireddy Ramana , Khan Sana , Leaver Chad , Martin Cally , Jin Albert , Durafourt Bryce A , Archer Stephen L
Published: August 2019

Background

Timely, in-person access to health care is a challenge for people living with conditions such as stroke that result in frailty, loss of independence, restrictions in driving and mobility, and physical and cognitive decline. In Southeastern Ontario, access is further complicated by rurality and the long travel distances to visit physician clinics. There is a need to make health care more accessible and convenient. Home virtual visits (electronic visits, eVisits) can conveniently connect physicians to patients. Physicians use a secure personal videoconferencing tool to connect to patients in their homes. Patients use their device of choice (smartphone, tablet, laptop, or desktop) for the visit.

Objective

This study aimed to assess the feasibility and logistics of implementing eVisits in a stroke prevention clinic for seniors.

Methods

A 6-month eVisit pilot study was initiated in the Kingston Health Sciences Centre stroke prevention clinic in August 2018. eVisits were used only for follow-up patient encounters. An integrated evaluation was used to test the impact of the program on clinic workflow and patient satisfaction. Patient satisfaction was evaluated by telephone interviews, using a brief questionnaire. Access and patient satisfaction metrics were compared with concurrent standard of care (patients’ prior personal experience with in-person visits). Values are presented as median (interquartile range).

Results

There were 75 subjects in the pilot. The patients were aged 65 (56-73.5) years, and 39% (29/75) resided in rural areas. There was a shorter wait for an appointment by eVisit versus in-person (mean 59.98 [SD 48.36] days vs mean 78.36 [SD 50.54] days; P<.001). The eVisit was also shorter, taking on an average of only 10 min to deliver follow-up care with a high degree of patient satisfaction versus 90 (60-112) min for in-person care. The total time saved by patients per eVisit was 80 (50-102) min, 44 (21-69) min of which was travel time. Travel distance avoided by the patients was 30.1 km (11.2-82.2). The estimated total out-of-pocket cost savings for patients per eVisit was Can $52.83 (31.26-94.53). The estimated savings (opportunity cost for in-person outpatient care) for our eVisit pilot project was Can $23,832-$28,584. The patient satisfaction with eVisits was very good compared with their prior personal experience with in-person outpatient care.

Conclusions

The eVisit program was well received by patients, deemed to be safe by physicians, and avoided unnecessary patient travel and expense. It also has the potential to reduce health care costs. We plan to scale the project within the department and the institution.
The Legal Status of Archipelagos in the International Law of the Sea
Authors: Gamil Aboukhewat Maher
Published: August 2019

The archipelagic States, which attempt to extend their control over the waters surrounding their islands, are demanding the establishment of a legal system for archipelagos in order to preserve their interests, their maritime wealth and their regional security. On the other hand, there are the great maritime States that hold on to the freedom of the sea and international navigation.The problems raised by the islands constituting the archipelago did not stand at the end of sovereignty disputes and their right to their own maritime areas, but many other problems were associated with the presence of archipelagic islands. The measurement of marine areas of archipelagic islands requires a description of how the baselines from which these areas are measured are to be drawn. Also, the measurement of marine areas of the islands of individual problems is different from those raised by the presence of the islands in the form of an archipelago. Drawing baselines also varies according to the archipelagic islands site, and whether they are located in front of the coast regions or at the entrances to the bays in these coasts, or were located in the sea or ocean.These problems remained subject to international controversy and tension until a new system of archipelagic State was adopted under Part IV of the United Nations Convention on the Law of the Sea in 1982, which represents a very important renewal of the international law of the sea.