bluuebunny/crossref_metadata_2025 huggingface dataset:
Transition Metal Catalyzed Aerobic Asymmetric Coupling of 2-Naphthols
Authors: Tkachenko Nikolay V. , Bryliakov Konstantin P.
Published: April 2018

Optically pure 1,1′-bi-2-naphthol (BINOL) and its derivatives are among the most widely used chiral ligands and auxiliaries for asymmetric synthesis. These molecules also occur as scaffolds for various biologically active compounds. Direct oxidative coupling of 2-naphthols in the presence of chiral catalysts provides a powerful strategy for the synthesis of optically pure 1,1′-bi-2-naphthols (BINOLS). In 1978, Wynberg with co-workers discovered that a copper salt with chiral auxiliary mediates the oxidative coupling of 2-naphthols, which can be taken as the starting point for further progress in this area. Over the last decades, a number of efficient and stereoselective catalyst systems have been developed. This mini-review surveys the aerobic asymmetric oxidative coupling of 2-naphthols catalyzed by transition metal complexes reported since 1995.
Prerequisite of a Holistic Blend of Traditional and Modern Approaches of Cancer Management
Authors: Kaushik Mahima , Mahendru Swati , Chaudhary Swati , Kumar Mohan , Kukreti Shrikant
Published: April 2018

Background:

With the advent of changes in lifestyle of people all around the world,
cancer cases have been showing an exponential rise. Researchers from varied fields have been trying
to solve this tricky issue.

Methods:

We undertook a systematic search of bibliographic databases of peer-reviewed research
literature to evaluate the holistic blend of modern and traditional approaches, especially the
Ayurvedic perspective of treatment of cancer along with the effect of our diet and lifestyle on the
management (both prevention and cure) of cancer.

Results:

On the basis of extensive literature survey, it was found that Ayurveda as one of the ancient
medicinal systems had been very well documented for utilizing its best practices for the
treatment of various diseases including cancer, by utilization of several herbal plants and dietary
interventions as therapeutics. Active components present in various herbs, which interfere with
certain molecular targets to inhibit carcinogenesis are also summarized. Further, beneficial effects
of yoga and exercise on psychological distress, cancer-related fatigue and global side-effects as
well as their mechanism of action are also discussed. In addition, we recapitulate an upcoming
field of Ayurgenomics to understand the possible correlation of Prakriti with genetics as well as
epigenetics.

Conclusion:

Both genetic as well as environmental factors have shown their linkage with cancer.
Substantial advancements in the field of targeted therapies have opened new horizons for the cancer
patients. To fight with this grave situation, a combination of ancient and modern medicinal
systems seems to be the need of the hour.
SGLT-2 Inhibition: Novel Therapeutics for Reno-and Cardioprotection in Diabetes Mellitus
Authors: Gill Angus , Gray Stephen P. , Jandeleit-Dahm Karin A. , Watson Anna M.D.
Published: April 2018

Background:

The sodium glucose co-transporter 2 (SGLT2) is primarily located within S1 of the renal proximal tubule being responsible for approximately 90% of glucose re-uptake in the kidney. Inhibition of SGLT2 is an exciting new pharmacological approach for the reduction of blood glucose in type 2 diabetic patients via inhibition of tubular glucose reabsorption. In addition to lowering glucose, this group of drugs has shown significant cardiovascular and renal protective effects.

Conclusion:

This review aims to outline the current state of preclinical research and clinical trials for different SGLT2 inhibitors and outline some of the proposed mechanisms of action, including possible effects on sympathetic nerve activity, which may contribute to the unexpected beneficial cardiovascular and reno-protective effects of this class of compounds.
Complement Components, C3 and C4, and the Metabolic Syndrome
Authors: Copenhaver Melanie , Yu Chack-Yung , Hoffman Robert P.
Published: April 2018

Introduction: Increased systemic inflammation plays a significant role in the development
of adult cardiometabolic diseases such as insulin resistance, dyslipidemia, atherosclerosis, and
hypertension. The complement system is a part of the innate immune system and plays a key role in the
regulation of inflammation. Of particular importance is the activation of complement components C3
and C4. C3 is produced primarily by the liver but is also produced in adipocytes, macrophages and
endothelial cells, all of which are present in adipose tissues. Dietary fat and chylomicrons stimulate C3
production. Adipocytes in addition to producing C3 also have receptors for activated C3 and other
complement components and thus also respond to as well as produce a target for complement. C3adesArg,
also known as acylation stimulation factor, increases adipocyte triglyceride synthesis and
release. These physiological effects play a significant role in the development of metabolic syndrome.
Epidemiologically, obese adults and non-obese adults with cardiometabolic disease who are not obese
have been shown to have increased complement levels. C4 levels also correlate with body mass index.
Genetically, specific C3 polymorphisms have been shown to predict future cardiovascular events and.
D decreased C4 long gene copy number is associated with increased longevity.

Conclusion:

Future research is clearly needed to clarify the role of complement in the development of
cardiovascular disease and mechanisms for its action. The complement system may provide a new area
for intervention in the prevention of cardiometabolic diseases.
Synthesis of Tetrapeptides and Screening of their Antioxidant Properties
Authors: Maharani Rani , Sumiarsa Dadan , Zainuddin Achmad , Ammatillah Nuruzzahra , Hidayat Ace T. , Harneti Desi , Nurlelasari  , Supratman Unang
Published: April 2018

Background:

Tetrapeptide Pro-Ala-Gly-Tyr (PAGY) is an antioxidant peptide that was isolated by Nikoo et al. (2014) from hydrolysate of skin gelatin of amur sturgeon fish (Acipenser schrenckii). This research aims to synthesize PAGY and its analogues by a solid-phase method, and to screen their antioxidant activities.

Methods:

PAGY and its analogues, namely, Pro-Ser-Gly-Tyr (PSGY), Pro-Ala-Phe-Tyr (PAFY), Pro- Phe-Phe-Tyr (PFFY) and Pro-Ala-Ile-Tyr (PAIY), were synthesized via a solid phase peptide synthesis method with the Fmoc/t-Bu strategy. The synthesis was undertaken on 2-chlorotritylchloride resin as solid support, and all coupling reactions were facilitated by a combination of HBTU and HOBt reagents. All peptides were cleaved from the resin by using 95% TFA in water.

Results:

Through the solid-phase synthesis method, all peptides were obtained in 50-85% yields. Pure peptides were analysed by analytical RP-HPLC, and were characterized by HR-TOF-ESI-MS and 1HNMR. DPPH inhibition assay was applied to all of the peptides with IC50 of 1.750; 1.116; 1.177 ;1.437; and 1.642 mg/mL for PAGY, PSGY, PAFY, PFFY, and PAIY, respectively.

Conclusion:

PAGY and its four analogs were successfully synthesized by solid-phase method. PSGY compound was found to have the highest activity of all in DPPH assay.
Quantification of Alpha Lipoic Acid in Pharmaceutical Products by HPLC with Pulsed Amperometric Detection at a Gold Electrode
Authors: Viana Carine , Ribeiro Sandra M. , Moreira Ana P.L. , Müller Larissa S. , Motta Monique J. , Monserrat José M. , de Carvalho Leandro M. , Bohrer Denise
Published: April 2018

Background:

Alpha-lipoic acid (ALA) has become a common ingredient in food supplements
and multivitamin formulas. ALA is widely used as therapy for preventing diabetic polyneuropathies,
scavenges free radicals, and restores intracellular glutathione levels. This study aimed to develop
a simple and fast analytical method to determine ALA content in dietary supplements using highperformance
liquid chromatography with pulsed amperometric detection (HPLC PAD).

Methods:

ALA was analyzed by HPLC in a mobile phase composed of 25 mmol/L potassium phosphate
in 50% (v/v) acetonitrile (pH 4.0) and PAD at a gold electrode (vs. solid-phase hydrogen reference
electrode). The PAD cycle was performed by applying a detection potential (E1) of +0.7 V for 0.4 s, an
oxidation potential (E2) of +1.0V for 0.4 s and a reduction potential (E3) of -0.2 V for 1.2 s.

Results:

The runtime method was shown a rapid procedure for the analysis of α-lipoic acid. The sampling
rate of 8 injections per hour was attained and measurements of the reproducibility of successive
injections (20 µL) showed an RSD of 1.89% for 16 successive injections. The method presented low
quantification limit of 0.21 mg/L. The industrialized ALA-based supplements ranged from to 97.8 to
104.1%, while manipulated capsules ranged from 69.2 to 95.4%.

Conclusion:

Electrochemical detector has been presented as an effective alternative for ALA determination,
which has weakly UV-absorbing. This detection has the benefits of sensitivity, simplicity and
low costs. The developed HPLC-DAD method proposes to be analytical tool applicable to quality control
of ALA supplements.
Study of Intrinsic Stability of Mometasone Furoate in Presence of Salicylic Acid by HPTLC and Characterization, Cytotoxicity Testing of Major Degradation Product of Mometasone Furoate
Authors: Vichare Vijaya , Choudhari Vishnu P. , Reddy M. Venkata
Published: April 2018

Background:

A successful attempt has been done to develop and validate a simple stability
indicating HPTLC method for the estimation of Mometasone furoate (MF) and its degradation product
in the presence of Salicylic acid (SA). The degradation product was isolated, characterized and tested
for cytotoxicity.

Introduction:

Mometasone furoate (MF) is chemically 9,21-Dichloro-17α-[(2-furanylcarbonyl) oxy]-
11β-hydroxy-16-α-methylpregna-1,4-diene-3,20-dione, a high potency glucocorticoid. Salicylic acid
(SA) has antiseptic, antifungal and keratolytic properties. Combination of MF and SA is available in the
market as an ointment and is used for the treatment of skin inflammation, skin diseases, acne, skin redness
and other conditions. Till now, there is no scientific documentation on HPTLC method for simultaneous
estimation of MF and SA in the topical formulation; stress testing of drugs and determination of
degradation products.

Methods:

Combination of Toluene: Ethyl Acetate: Methanol: Ammonia (6.4:1.5:2.0:0.1) was selected
as the mobile phase. Detection was done by UV absorbance mode at wavelength 250 nm. Topical formulation
containing MF and SA was analyzed by the developed method. The developed method was
validated as per ICH guidelines. The standard drugs were subjected to stress testing like hydrolysis,
oxidative, thermal and photolytic degradation.

Results:

Good separation with Rf values 0.61 ± 0.02 (MF) and 0.21 ± 0.02 (SA) was achieved by optimized
chromatographic conditions. The % drug content was found to be 97.41±1.15 and 99.43 ± 0.73
for MF and SA, respectively in a topical formulation. From the results of validation parameters, the
developed method was found to be specific, accurate, precise, sensitive and robust. After stress testing,
SA was found to be stable under different stress conditions. Whereas, MF was found to be base sensitive
and single degradation product was observed and isolated by preparative TLC. It was characterized
by LC-MS and LC-MS/MS studies. Isolated degradation product was subjected to cytotoxicity testing
on A549 and SiHa cell lines.

Conclusion:

A simple stability indicating HPTLC method was developed and validated for the
estimation of MF and its degradation product in presence of SA. Probable structure of degradation
product of MF and probable pathway of degradation was interpreted. Results of cytotoxicity testing
showed that the degradation product was more cytotoxic as compared to MF against both the cell lines.
Biuletyn studiów o karaitach
Authors: Tomalik Stanisław
Published: April 2018

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Legenda o Józefie Cieśli w kulcie oblubieńca Matki Bożej
Authors: Hergesel Tomasz
Published: April 2018

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Formularz mszalny na Rok Święty
Authors: Małaczyński Franciszek
Published: April 2018

-
Historyczność Jezusa Chrystusa w świetle antychrześcijańskich graffiti z Herodium
Authors: Chmiel Jerzy
Published: April 2018

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Na drodze do odnowienia dyscypliny sakramentu pokuty
Authors: Piątek Stanisław
Published: April 2018

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Sprawozdanie z sympozjum: obrzędy chrztu dzieci
Authors: Danielski Wojciech , Papiernik Bohdan
Published: April 2018

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Zasłużony prekursor ks. Jan Korzonkiewicz
Authors: Weryński Henryk
Published: April 2018

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Trzecia Księga Ezdrasza
Authors: Frankowski Janusz
Published: April 2018

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Gratia plena czy gratificata?
Authors: Bzowski Stanisław
Published: April 2018

-
Psalm 58 w świetle krytyki literacko-historycznej
Authors: Kończak Adam
Published: April 2018

-
Znaczenie nasienia w przypowieści o siewcy
Authors: Kokot Mirosław
Published: April 2018

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Działalność naukowa ks. Ludwika Stefaniaka, CM (1930–1972)
Authors: Kapera Zdzisław
Published: April 2018

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Community-Based, Point-of-Care Sexually Transmitted Infection Screening Among High-Risk Adolescents in Los Angeles and New Orleans: Protocol for a Mixed-Methods Study (Preprint)
Authors: Shannon Chelsea Lee , Koussa Maryann , Lee Sung-Jae , Fournier Jasmine , Abdalian Sue Ellen , Rotheram Mary Jane , Klausner Jeffrey D ,   Adolescent Medicine Trials Network CARES Team
Published: April 2018

BACKGROUND

Sexually transmitted infection (STI) rates are increasing in the United States, with approximately half of new infections occurring among adolescents aged 15-24 years. Gay, bisexual, and transgender youth (GBTY), homeless youth, and youth with histories of drug use, mental health disorders, and incarceration are all at uniquely high risk for STIs. However, these adolescents often lack access to sexual health services.

OBJECTIVE

This study aims to use point-of-care STI tests in community-based settings to screen for and treat STIs in adolescents.

METHODS

We are recruiting 1500 HIV-uninfected youth and 220 HIV-infected youth from homeless shelters, GBTY organizations, and community health centers in Los Angeles, California and New Orleans, Louisiana. Study participants will receive STI screening every 4 months for 24 months. STI screening includes rapid HIV, syphilis, Chlamydia trachomatis, Neisseria gonorrhoeae, and Hepatitis C virus testing. Trained paraprofessionals will conduct all STI testing. When a participant screens positive for an STI, they are either linked to a partner medical clinic or provided with same-day antibiotic therapy and expedited partner therapy. We will monitor STI prevalence among study participants as well as point-of-care test performance, linkage to care, and treatment outcomes.

RESULTS

The project was funded in 2016, and enrollment will be completed in 2019. Preliminary data analysis is currently underway.

CONCLUSIONS

As STI rates continue to rise, it is important to improve access to screening and treatment services, particularly for high-risk adolescents. In this study, we aim to evaluate the use of point-of-care STI diagnostic tests in community-based organizations. We hope to determine the prevalence of STIs among these adolescents and evaluate the acceptability and feasibility of community-based STI screening and treatment.

CLINICALTRIAL

ClinicalTrials.gov NCT03134833; https://clinicaltrials.gov/ct2/show/NCT03134833

INTERNATIONAL REGISTERED REPOR

DERR1-10.2196/10795
ÖLÇEK BAZLI FİNANSAL PERFORMANSIN PROMETHEE YÖNTEMİYLE BELİRLENMESİ: FARKLI AĞIRLIKLANDIRMA YÖNTEMLERİNE DAYALI KARŞILAŞTIRMALI BİR ANALİZ
Authors: Apan Mehmet , Öztel Ahmet
Published: April 2018

Amaç: İmalat sektörünün performansı, ekonomik
analizlerde gösterge olarak takip edilmektedir. Bu çerçevede imalat sektörünün
performansı; şirket hissedarları, potansiyel yatırımcılar ve sektöre yatırım
düşünen girişimciler ile yatırım teşviklerinin kapsamının belirlenmesinde
gösterge olarak dikkate alınmaktadır. İşletmelerin ölçek farklılıkları
nedeniyle doğrudan ölçek bazında finansal performansını belirlemede de
farklılaştırmayı zorunlu hale getirmektedir. Bu kapsamda imalat sektöründeki
firmaların Küçük Ölçekli İşletme (KÖİ), Orta Ölçekli İşletme (OÖİ), Büyük Ölçekli
İşletme (BÖİ) ve Tüm Sektör (TS) şeklinde ölçek bazında finansal performansların
belirlenmesi amaçlanmaktadır. Ayrıca finansal performans değerlendirmesi için kullanılan
farklı ağırlıklandırma yöntemleri ile bulunan sonuçlar arasında fark olup
olmadığının belirlenmesi amaçlanmaktadır.Yöntem: İmalat
sektöründeki işletmeler; KÖİ, OÖİ, BÖİ ve TS şeklinde ölçeklendirilerek ÇKKV (Çok
Kriterli Karar Verme) yöntemlerinden PROMETHEE yöntemi ile analiz edilmiştir. Çalışmada,
Türkiye Cumhuriyet Merkez Bankası (TCMB)’ndan sağlanan sektör bilançolarından
imalat sektörünün 2004-2014 dönem verisi kullanılmıştır. Finansal performans
kriterlerinin göreceli önemlerinin belirlenmesi için Entropi, CRITIC, Standart
Sapma ve Ortalama Ağırlıklandırma yöntemleri kullanılarak ölçek bazında
karşılaştırmalı bir yaklaşım sunulmuştur.Bulgular: Ağırlıklandırma yöntemlerine göre işletme
ölçeklerinin yıllar itibariyle farklı finansal performans skorları ve sıralamasına
neden olduğu ve işletme ölçeklerinin birbirleri arasındaki korelasyonlarda her
bir ağırlıklandırma yöntemine göre farklılaşma olduğu bulguları elde edilmiştir.

Sonuç: Ampirik analizlerde
ölçeklere dayalı olarak imalat sektörünün finansal performansında farklılıklar
ve benzerlikler görülmüştür. Genel olarak BÖİ ile TS benzer bir performans
sıralaması elde etmiştir. Diğer ölçeklerde ise genel olarak farklı
performanslar gözlenmiştir. Ayrıca kullanılan ağırlıklandırma yöntemine göre
farklı sonuçlara ulaşılmıştır. Bu da ağırlıklandırma yöntemlerinin ÇKKV
problemlerinde önemli bir etkiye sahip olduğu görülmüştür.
Diversity in Children’s Literature
Authors: Leahy Marie A. , Foley Bridget C.
Published: April 2018

Children’s literature is profoundly influential in the lives of students and is widespread throughout schools, libraries, and homes. However, the field of children’s literature lacks diversity across several domains, particularly race, gender, and ability. Educators must be knowledgeable on how to use diverse children’s literature as a tool to teach about diversity, as they strive to foster inclusive classroom environments. Teachers must also design their classroom libraries with intense care so as to provide a wide-ranging selection of books to meet the needs of children’s interests and reading levels. Books are a powerful tool for development, so teachers must make conscious decisions about the materials they provide to young readers. All children deserve exposure to a wide range of books, which include characters who are both similar and different from themselves. Educators have a responsibility to expose students to diversity through a well-written selection of multifaceted children’s literature.
Sharing Selves: Developing an Ethical Framework for Curating Social Media Data
Authors: Mannheimer Sara , Hull Elizabeth A.
Published: April 2018

Open sharing of social media data raises new ethical questions that researchers, repositories and data curators must confront, with little existing guidance available. In this paper, the authors draw upon their experiences in their multiple roles as data curators, academic librarians, and researchers to propose the STEP framework for curating and sharing social media data. The framework is intended to be used by data curators facilitating open publication of social media data. Two case studies from the Dryad Digital Repository serve to demonstrate implementation of the STEP framework. The STEP framework can serve as one important â€˜stepâ€™ along the path to achieving safe, ethical, and reproducible social media research practice.
ELE VEIO COMIGO: AUTOR, NARRADOR, GÊNERO E DOMINAÇÃO MASCULINA EM UM ROMANCE DE ELVIRA VIGNA
Authors: Paschoal Ana Cláudia
Published: April 2018

Este artigo visa a analisar as figuras do autor e do narrador dentro do romance policial Deixei ele lá e vim, de Elvira Vigna e, dessa forma, discutir a dimensão do pensamento androcêntrico em que se baseiam certas estruturas sociais. Sendo assim, reflexões sobre autor e narrador, bem como questões relativas a gênero e à dominação masculina são fundamentais para a elaboração deste estudo. Demonstra-se que a protagonista do romance examinado é construída de modo a revelar adesão às estruturas de dominação masculina que norteiam suas relações dentro de uma narrativa repleta de ambiguidades.
DISCIPLINAMENTO DOS CORPOS E AS TECNOLOGIAS DISCIPLINARES EM EM NOME DO DESEJO, DE JOÃO SILVÉRIO TREVISAN
Authors: Costa-Almeida Pamella Oliveira
Published: April 2018

Considerando o crescente no tocante à literatura brasileira de temática gay, este artigo almeja contribuir para o aporte teórico e crítico em construção sobre o tema. Para isso, pretende-se fazer uma análise do romance Em nome do desejo (2001), de João Silvério Trevisan, acerca do que corresponde ao disciplinamento dos corpos, proposto principalmente por Michel Foucault (1998, 1996), que teorizou sobre a construção da sexualidade e do disciplinamento dos corpos colocados em constante vigilância a fim de garantir que não se se desviassem do padrão considerado adequado. Pretendeu-se aqui observar a forma como cada dispositivo e tecnologia de poder age em consonância com a norma pré-estabelecida de heteronormatividade.
A HORA DA ESTRELA: ARTESANATO ESCRITURAL OU CAOS NARRATIVO?
Authors: Cunha Betina Ribeiro Rodrigues da
Published: April 2018

Estas anotações apresentam uma reflexão apreciativa do jogo-brincadeira discursiva emergente do discurso narrativo contemporâneo, do qual Clarice Lispector, em A hora da estrela, é tomada como representante-proponente de uma arquitetura textual solapada pelo exercício lúdico, oferecendo, ao mesmo tempo que busca, questiona e desvela – uma feição mais harmoniosa e mais poeticamente lúcida da condição humana, no âmbito das relações entre narrador, autor, personagem e leitor.
LAMENTO DE UM BLUE
Authors: Sá Olga De
Published: April 2018

O texto focaliza, principalmente, a edição especial comemorativa da publicação dos 40 anos de A hora da estrela e da morte de sua Autora, Clarice Lispector.
A REPRESENTAÇÃO DOS CIGANOS EM CONTOS DE JORGE MEDAUAR
Authors: Assis Luana Isabel Silva de , Jutgla Cristiano Augusto Da Silva
Published: April 2018

O artigo apresenta uma análise sobre a representação dos ciganos nos contos “O cigano” e “A volta do cigano”, publicados pela primeira vez no livro A procissão e os porcos (1960), do escritor sul-baiano Jorge Medauar. Assim, discutimos como o escritor destaca a presença dos povos ciganos no interior do sul da Bahia, além de abordarmos os aspectos de sua narrativa e questões de alteridade.
POSSIBILIDADE DE LEITURA CRÍTICA A PARTIR DO CONTO “THE LAST POOR MAN”, DE MOACYR SCLIAR, MEDIADA PELAS TIC
Authors: Silva Marli Teresinha da , Mügge Ernani , Barbosa Débora Nice Ferrari
Published: April 2018

O objetivo deste artigo é apresentar uma proposta de leitura crítica do conto “The last poor man”, de Moacyr Scliar, aplicada em aulas de Língua Inglesa do ensino médio. O roteiro de atividades está ancorado na metodologia de análise textual proposta por Juracy Assmann Saraiva (2001/2006), que tem por base a Estética da Recepção, e prevê a utilização das tecnologias da informação e da comunicação (TIC) e o exercício da interdisciplinaridade. Ao propor a leitura e análise de textos ficcionais brasileiros, traduzidos para o inglês, nas aulas, defende-se a ideia de que eles podem contribuir ao processo de ensino e aprendizagem na medida em que permitem, ao aluno, refletir sobre a realidade que o circunda e sobre si mesmo, atendendo, assim, às orientações explicitadas pelos documentos que orientam a educação do país.
(RE)PENSANDO A LEITURA DE TEXTOS VERBOS-VISUAIS NO ENSINO MÉDIO
Authors: Pereira Mirian Alves , Modl Fernanda Castro
Published: April 2018

Neste artigo, discutimos acerca da produtividade de pressupostos teórico-metodológicos da Análise do Discurso Francesa em práticas de leitura/interpretação de textos verbo-visuais nas aulas de Língua Portuguesa do Ensino Médio. Interessa-nos, assim, analisar como dois professores de Português da referida etapa de escolarização (res)significam, em seus posicionamentos discursivos, possibilidades de didatização da leitura de textos verbo-visuais a partir das discussões teórico-metodológicas alicerçadas na Análise do Discurso Francesa a eles apresentadas em oficina pedagógica ministrada pela pesquisadora. Para isso, amparamo-nos em pressupostos teóricos da Análise do Discurso Francesa (PÊCHEUX, 1999; ORLANDI, 1998, 2003) para referenciar o tratamento do texto em sua discursividade e nos estudos acerca dos gêneros discursivos (SCHNEUWLLY, 2004; BAKHTIN, 1984) no contexto do ensino. As análises apontam para uma ressignificação das leituras dos sujeitos de pesquisa, e, consequentemente, para um redimensionamento do tratamento didático de textos verbo-visuais a partir de um momento formativo.
METASSÍNTESE QUALITATIVA SOBRE OS ESTUDOS DE CRENÇAS, EMOÇÕES E IDENTIDADE (2009-2015)
Authors: Martins Suellen Thomaz de Aquino , Souza Núbia Enedina Santos , Aragão Rodrigo Camargo
Published: April 2018

Buscamos neste artigo mapear estudos que considerem o papel das emoções e crenças no ensino-aprendizagem de Língua Estrangeira (LE) e como se dá a inter-relação desses fenômenos com a identidade do professor de LE. Apresentamos uma metassíntese qualitativa de estudos envolvendo estes conceitos, publicados no Brasil entre 2009 e 2015. A base de dados da SciELO foi utilizada como fonte na busca por periódicos com webqualis de relevância A1a B3 da área de Letras/Linguística. Os resultados indicam que a maioria dos estudos se debruçam sobre crenças e identidade de professor de línguas em formação inicial e continuada. Observarmos um leve pressionamento sobre as questões de crenças e emoções. Apontamos a necessidade de estudos que relacionem crenças-identidade-emoções no ensino-aprendizagem e formação do professor de LE, visto que, nesta metassíntese qualitativa, não foi encontrado nenhum trabalho que envolvesse os três conceitos como parte de um mesmo estudo.
Feedback linearization for decoupled position/stiffness control of bidirectional antagonistic drives
Authors: Jovanovic Kosta , Lukic Branko , Potkonjak Veljko
Published: April 2018

To ensure safe human-robot interaction impedance robot control has arisen as
one of the key challenges in robotics. This paper elaborates control of
bidirectional antagonistic drives - qbmove maker pro. Due to its mechanical
structure, both position and stiffness of bidirectional antagonistic drives
could be controlled independently. To that end, we applied feedback
linearization. Feedback linearization based approach initially decouples
systems in two linear single-input-single-output subsystems: position
subsystem and stiffness subsystem. The paper elaborates preconditions for
feedback linearization and its implementation. The paper presents simulation
results that prove the concept but points out application issues due to the
complex mechanical structure of the bidirectional antagonistic drives.
Mandibular asymmetries and associated factors in orthodontic and orthognathic surgery patients
Authors: Thiesen Guilherme , Gribel Bruno F. , Freitas Maria Perpétua M. , Oliver Donald R. , Kim Ki Beom
Published: April 2018

Objectives:

To estimate the prevalence of mandibular asymmetries in orthodontic and orthognathic surgery patients and to investigate demographic and skeletal factors associated with this disharmony.

Materials and Methods:

Cone-beam computed tomography images of 1178 individuals aged 19 through 60 years with complete dentitions were analyzed. Outcomes were classified as relative mandibular symmetry, moderate asymmetry, and severe asymmetry. Factors recorded included sex, age, side of mandibular deviation, sagittal jaw relationship, vertical skeletal pattern, angle of the cranial base, and maxillary asymmetry. Ordinal logistic regression was used to estimate simple and adjusted odds ratios (OR) for the individuals with moderate and severe mandibular asymmetry, as well as 95% confidence intervals.

Results:

Prevalence values of 55.2%, 27.2%, and 17.6% were observed for relative mandibular symmetry, moderate asymmetry, and severe asymmetry, respectively. An independent association with the side of mandibular deviation and the presence of maxillary asymmetry was observed, both for subjects with moderate mandibular asymmetry (left side: OR = 1.50; 95% CI: 1.01–2.24 / maxillary asymmetry: OR = 2.07; 95% CI: 1.11–3.76) and for those with severe asymmetry (left side: OR = 2.09; 95% CI: 1.27–3.44 / maxillary asymmetry: OR = 4.93; 95% CI: 2.64–9.20).

Conclusions:

Moderate and severe mandibular asymmetries were present in 44.8% of the sample, being associated with the side of mandibular deviation and with maxillary asymmetry.
Concepções dos professores coordenadores sobre estudantes com autismo
Authors: Souza Borges de Carvalho Cintia , Cabestré Amorim Gabriely
Published: April 2018

A presente pesquisa analisa as concepções de professores coordenadores (PC) atuantes no Ensino Fundamental (EF) - anos iniciais, sobre a inclusão de estudantes com autismo. Objetivou-se descrever, sob a ótica desses profissionais, as concepções a respeito de estudantes com autismo, refletindo sobre como estas podem influenciar na formação continuada dos professores e, consequentemente, na inclusão destes alunos. Trata-se de pesquisa qualitativa, em que foram realizadas entrevistas durante os meses de setembro e outubro de 2015, com cinco PC responsáveis pelo EF. Os dados indicam que, embora conheçam as definições sobre o autismo, ainda possuem uma visão médica sobre seus estudantes, a qual exerce influência na inclusão no ensino regular, na relação com as famílias e, sobretudo, na formação dos educadores. Assim sendo, considera-se fundamental uma formação sistemática aos PC sob uma perspectiva reflexiva e inclusiva, para que se possa articular o trabalho pedagógico com os professores, possibilitando real inclusão do estudante com autismo.
Editorial
Authors: Sanfelice Jose Luis
Published: April 2018

Editorial
A comparison of sex identification methods based on lip furrow pattern
Authors: Topczyłko Aleksandra , Borysławski Krzysztof , Nowakowski Dariusz
Published: April 2018

The objective of the study was to specify the method with the highest probability of correct sex identification based on lip furrow pattern. Three methods were verified: Vahanwala’s method, identification based on the mid-section of lower lip print and our own method. The examined group included 242 persons aged 15- 30 years, 68.6% females and 31.4% males. Cheilograms were taken with the method proposed by Vanahwala, modified in such a way that the prints of lower and upper lips were taken separately. The lip furrow patterns were classified according to Suzuki and Tsuchihashi, modified to include horizontal furrows which were considered by Renaud. In all the quadrants patterns II, III and VI prevailed among males and patterns I, I’ and II among females. Females were more frequently diagnosed correctly than males. Our method in which all the lip print was analysed without division into quadrants was the most effective, while Vahanwala’s method was the least so.
Skeletal evidence of Diffuse Idiopathic Skeletal Hyperostosis (DISH) in a collective burial from Byzantine Greece
Authors: Tritsaroli Paraskevi
Published: April 2018

The paper reports on a collective burial from a 13th c. AD cist grave in Attica, Greece. The grave was located inside a basilica and held the remains of at least ten adults. Bone representation analysis showed secondary manipulation of previous deceased including long bone selection for reburial in the same grave and/or bones transported from a different burial place. Paleopathological analysis used macroscopy and radiology, and revealed several lesions on the axial and appendicular skeleton expressed mainly by spinal ligament ossification and multiple peripheral enthesopathies. Individuation of the remains pointed to a middle-aged male with DISH, a condition often correlated to high social rank. Byzantine period is marked by increasing development and prosperity in Greece including among others the creation of many local monastic centers. Although the precise social and professional profile of these individuals cannot be revealed, the combined investigation of skeletal and archaeological evidence suggests that the grave gathered the remains of individuals belonging to an upper class social group.
Campus Environmental Factors And Job Commitment Of Staff In State Universities In Ogun Southwest Nigeria
Authors: Oludeyi Olukunle Saheed , Momoh Agbomehre Medina , Akinsanya A. O.
Published: April 2018

The study investigated the influence of campus environmental factors on job commitments. The research design was quantitative descriptive sample survey of ex-post facto type while the population includes both male and female senior non-teaching staff of Olabisi Onabanjo University, Ogun State. Multi-stage sampling technique was used in choosing 200 participants selected from nine faculties and one college. A structured and close-ended questionnaire titled ‘Campus Environmental Factors and Job Commitment Questionnaire’ with reliability co-efficient of 0.85 obtained through Cronbach alpha methods was administered. 170 were retrieved from the 200 instruments administered. Data were analysed using frequency count, simple percentage, Pearson Correlation, and t test of significance. The study demonstrated a significant positive influence of campus environmental factors on job commitments of staff in the university. Useful recommendations were also raised.
Becoming a Follower of Christ: Exploring Conversion Through Historical and Missiological Lenses
Authors: Das Rupen
Published: April 2018

Conversion is a critical part of Evangelical theology and missiology. It has been defined as a crisis experience or a decision at a specific point in time. However, there is always an aspect of development, a process, involved. Increasingly, the phenomenon of conversion of those from non-Christian backgrounds, for example from other world religions, indicates that how they become followers of Christ is often characterised by a gradual journey, sometimes accompanied by visions and dreams. This paper looks at the phenomenon of conversion through a historical and missiological lens to explain and understand the dynamics of the conversion.
Epoxidation of natural limonene extracted from orange peels with hydrogen peroxide over Ti-MCM-41 catalyst
Authors: Wróblewska Agnieszka , Miądlicki Piotr , Makuch Edyta , Benedyczak Natalia
Published: April 2018

The paper presents the oxidation of natural limonene (extracted from waste orange peels) by 60 wt% hydrogen peroxide, in the presence of Ti-MCM-41 catalyst and in methanol as the solvent. The aim of the research was to develop the most favorable technological parameters for the process of limonene oxidation (temperature, molar ratio of limonene to hydrogen peroxide, methanol concentration, Ti-MCM-41 catalyst content and reaction time) by analyzing changes in the main functions describing this process: the conversion of limonene, selectivities of appropriate products, the conversion of hydrogen peroxide and the effective conversion of hydrogen peroxide. The process is environmentally friendly process and it uses renewable raw material - limonene and a safe oxidant -hydrogen peroxide. During the study, very valuable oxygenated derivatives of limonene were obtained: 1,2-epoxylimonene, its diol, carvone, carveol, and perillyl alcohol. These compounds are used in medicine, cosmetics, perfumery, food and polymers industries.
Ultrasound-assisted emulsification–microextraction and spectrophotometric determination of cobalt, nickel and copper after optimization based on Box-Behnken design and chemometrics methods
Authors: Doroudi Zohreh , Niazi Ali
Published: April 2018

A fast, simple, and economical method for extraction, preconcentration and determination of cobalt, nickel and copper as their 1-(2-pyridilazo) 2-naphthol (PAN) complexes based on ultrasound-assisted emulsification–microextraction (USAEME) and multivariate calibration of spectrophotometric data is presented. Various parameters affecting the extraction efficiency were optimized both with univariate and Box–Behnken design. The resolution of ternary mixtures of these metallic ions was accomplished by using partial least-squares regression (PLS), orthogonal signal correction-partial least-squares regression (OSC-PLS), and orthogonal signal correction-genetic algorithmspartial least-squares regression (OSC-GA-PLS). Under the optimum conditions, the calibration graphs were linear in the range of 2.0–150.0, 2.0–120.0 and 2.0–150.0 ng mL−1 for Co2+, Ni2+, and Cu2+, respectively, with a limit of detection of 0.14 (Co2+), 0.13 (Ni2+) and 0.14 ng mL−1 (Cu2+) and the relative standard deviation was <2.5%. The method was successfully applied to the simultaneous determination of these cations in different samples.
Preparation and properties of nanocrystalline Ni/graphene composite coatings deposited by electrochemical method
Authors: Cieślak Grzegorz , Trzaska Maria
Published: April 2018

The paper presents results of studies of composite nickel/graphene coatings produced by electrodeposition method on a steel substrate. The method of producing composite coatings with nanocrystalline nickel matrix and dispersion phase in the form of graphene is presented. For comparative purposes, the study also includes nano-crystalline Ni coatings produced by electrochemical reduction without built-in graphene flakes. Graphene was characterized by Raman spectroscopy, transmission and scanning electron microscopes. Results of studies on the structure and morphology of Ni and Ni/graphene layers produced in a bath containing different amounts of graphene are presented. Material of the coatings was characterized by SEM, light microscopy, X-ray diffraction. The microhardness of the coatings was examined by Knoop measurements. The adhesion of the coatings with the substrate was tested using a scratchtester. The influence of graphene on the structure and properties of composite coatings deposited from a bath with different graphene contents was determined.
Composite coatings with nickel matrix and graphene as dispersed phase
Authors: Gajewska-Midziałek Anna
Published: April 2018

The paper presents the results of the studies of nickel-graphene composite coatings deposited by the electrochemical reduction method. A bath with low concentration of nickel ions, graphene as dispersed particles and organic compounds were used for deposition of the composite coatings nickel-graphene. The results of investigations of coatings deposited from the electrolyte containing 0.33, 0.5 and 1 g/dm3 graphene and two surface-active compounds were shown. The particles content in the coatings, the surface morphology, the cross-sectional structures of the coated samples, thickness and internal stresses were measured. Voltammetric method was used for examination of the corrosion resistance of samples of composite coatings in 0.5 M NaCl solution. The obtained results suggest that the content of incorporated graphene particles increases with an increasing amount of graphene in plating bath. The applications of organic addition agents was advantageous because it caused compressive stresses in the coatings. All of the nickel-graphene composite coatings had better corrosion resistance than the nickel coatings.
PIV measurement of tube-side in a shell and tube heat exchanger
Authors: Wang Kai , Zhang Zixu , Liu Qiong , Tu Xincheng , Kim Hyoung-Bum
Published: April 2018

In order to improve the performance of the shell and tube heat exchanger, a porous baffle and a splitter bar are employed in this research. Through the arrangement of the porous baffle in the tube-side inlet and the splitter bar in the tube, the flow distribution of liquid in the heat exchanger is improved. PIV technology is used to investigate the unsteady flow in the tube-side inlet and the outlet of different models. The porous baffle significantly improves the flow of fluid in the shell and tube heat exchanger, especially by eliminating/minimizing the maldistribution of fluid flow in the tube-side inlet. The performance of the arc baffle is better than that of the straight baffle. The splitter bar has a minimal effect on the flow field of the tube-side inlet, but it effectively improves the flow in the tube bundle and restrains the vortex generation in the tube-side outlet.
Effects of processing parameters on the properties of amphiphilic block copolymer micelles prepared by supercritical carbon dioxide evaporation method
Authors: Jiao Zhen , Wang Ziyi , Wang Xiudong , Fan Wenjing
Published: April 2018

The operation parameters for the supercritical carbon dioxide (ScCO2) evaporation method greatly affect the properties of the prepared drug-loaded micelles. In this study, the effects of those key parameters on the drug-loading content (LC) and drug entrapment efficiency (EE) are discussed. It is observed that EE and LC of the micelles are slightly increased with the enhancing temperature and the copolymer molecular ratio of hydrophilic/hydrophobic segment, while decreased with the enhancing ScCO2 evaporation rate. The pressure and volume ratio of ScCO2 to H2O are observed the optimum condition. In addition, the verification experiment is carried out under the obtained optimizing parameters. The prepared micelles exhibit relatively regular spherical shape and narrow size distribution with the EE and LC value of 70.7% and 14.1%, respectively.
Rare Renal Disease in Macedonia – An Update
Authors: Tasic Velibor , Gucev Zoran , Polenakovic Momir
Published: April 2018

Rare renal diseases (RRD) are an important category of rare disease (RD) as they can do great damage to the patients, families and society. The patient may undergo years even decades of numerous investigations including invasive procedures and yet not have definitive and precise diagnose and therefore, no opportunity for appropriate treatment. The great progress in molecular genetic techniques characterized many Mendelian diseases on molecular level. This gave the possibility for appropriate prevention and treatment interventions, genetic counseling and prenatal diagnosis. Herein, we summarize the current status of RRD in Macedonia. The research interest of Macedonian clinicians and scientists is focused on the genetics of congenital anomalies of the kidney and urinary tract (CAKUT), steroid resistant nephrotic syndrome, nephrolithiasis and nephrocalcinosis, cystic diseases and cilliopathies with collaborations with eminent laboratories in Unites States and Europe. This collaboration resulted in detection of new genes and pathophysiological pathways published in The New England Journal of Medicine and in other high impact journals. Macedonian health professionals have knowledge and equipment for diagnosis of RRD. Unfortunately the lack of finances is great obstacle for early and appropriate diagnosis. Participation in the international registries, studies and trials should be encouraged. This would result in significant benefit for the patients, health professionals and science.
Secondary Hodgkin Lymphoma and Myelodysplastic Syndrome (MDS) After Paclitaxel-Carboplatin Treatment in a Patient with Small Cell Lung Cancer
Authors: Petrusevska Marija , Stavridis Irina Panovska , Mladenovska Kristina , Petrushevska Gordana
Published: April 2018

Herein synchronous occurrence of Hodgkin lymphoma and secondary myelodysplastic syndrome in a 60 year old male patient with small cell lung cancer treated with combined chemotherapy (carboplatin and paclitaxel) and radiotherapy is presented. The objective of this report is to stress the importance of documenting and monitoring adverse drug reactions that arise from chemotherapy.

After four years of treatment with the combined chemotherapy, the patient presented inguinal lymphadenopathy and enlarged lymph nodes and histopathology rapport was suggestive for plasmacytoid variant of Castleman disease. Three years later, biopsy of lymph node was performed and diagnosis of Hodgkin lymphoma – mixed cellularity has been established. Molecular analyses revealed presence of dominant monoclonal population of the immunoglobulin genes in the oligo/monoclonal background. Bone marrow biopsy findings suggested secondary myelodysplasia and revealed signs of hematopoietic cells dismaturation with signs of megaloblastic maturation of the erytropoetic lineage, appearance of ALIP (abnormal localization of immature precursors) in the myeloid lineage and dysplastic megakaryocytes. In addition, an increased level of polyclonal plasmacytes (lambda vs kappa was 60%:40%) was found.

Hodgkin lymphoma and MDS occurring after 4 years of carboplatin/paclitaxel therapy might be contributed to the accumulation of alkylator-related DNA damage. This emphasize the need of outlining a monitoring plan regarding development of secondary leukemia and other malignant hematological proliferations should be outlined in the protocols.
The Effect of Rectus Sheath Block as a Supplement of General Anesthesia on Postoperative Analgesia in Adult Patient Undergoing Umbilical Hernia Repair
Authors: Kartalov Andrijan , Jankulovski Nikola , Kuzmanovska Biljana , Zdravkovska Milka , Shosholcheva Mirjana , Tolevska Marija , Naumovski Filip , Srceva Marija , Petrusheva Aleksandra Panovska , Selmani Rexhep , Sivevski Atanas
Published: April 2018

Background: Ultrasound guided rectus sheath block can block the ventral rami of the 7th to 12th thoracolumbar nerves by injection of local anesthetic into the space between the rectus muscle and posterior rectus sheath. The aim of this randomized double-blind study was to evaluate the analgesic effect of the bilateral ultrasound guided rectus sheath block as supplement of general anesthesia on patents undergoing elective umbilical hernia repair.

Methods: After the hospital ethics committee approval, 60 (ASA I–II) adult patients scheduled for umbilical hernia repair were included in this study. The group I (n=30) patents received only general anesthesia. In the group II (n = 30) patents after induction of general anesthesia received a bilateral ultrasound guided rectus sheath block with 40 ml of 0.25% bupivacaine. In this study we assessed demographic and clinical characteristics, pain score - VAS at rest at 2, 4, 6, 12 and 24 hours after operation and total analgesic consumption of morphine dose over 24-hours.

Results: There were statistically significant differences in VAS scores between the groups I and II at all postoperative time points - 2hr, 4 hr, 6 hr, 12 hr and 24 hr. (P < 0.00001). The cumulative 24 hours morphine consumption after the operation was significantly lower in the group II (mean = 3.73 ± 1. 41) than the group I (mean = 8.76 ± 2.41). This difference was statistically significant (p = 0.00076).

Conclusion: The ultrasound guided rectus sheath block used for umbilical hernia repair could reduce postoperative pain scores and the amount of morphine consumption in 24 hours postoperative period.