bluuebunny/crossref_metadata_2025 huggingface dataset:
Some Studies on Discolouration Effect of Electric Light Sources on Oil Painting and Water Colour Painting in Museum
Authors: Ghosh Kamalika , Mondal Anubrata
Published: January 2025

Preservation of paintings in museum or art galleries, especially of organic materials like paper and textiles, is a great concern. It is crucial to have proper illumination to see an object. Due to urbanization, in most of the place’s daylight is not sufficient. Due to this, usage of electric lighting, with advanced technology, is highly important. The majority of electric lighting release corrosive ultra violet rays (UV). It can be observed that UV ray is also present as a neighbour of visible light. The discoloration effects of UV content, are due to its high energy concentration, leads to day-by-day discolouration of painting. Before using the electric light sources, it is important to check their UV content. For this, a comprehensive analysis and experiment have been carried out. This paper aims to investigate the UV content of various electric light sources and how it affects paintings like water colour and oil paintings. The primary hues red, green, blue, as well as gold and silver, have all been the subject of experiments. To illustrate the nature of the discolouration power of various types of lamps, results have been furnished in the form of tables as well as graphs. In this regard, appropriate light sources can be employed to prevent paintings from discoloration.
Illumination of Workplaces in Classrooms of Higher Educational Institutions
Authors: Korol Elena A. , Degaev Evgeniy N.
Published: January 2025

Lighting is one of the key factors affecting human productivity and health. Correctly calculated illumination of workplaces ensures comfort and safety, reduces eye fatigue and increases work efficiency. The values of the illumination of the classroom were calculated using the standard methodology and the DIALux software. The types, powers, and luminous fluxes of the used lamps were determined. Measurements of the actual illuminance levels were carried out in order to determine its compliance with established illumination standards. The actual illumination of the classroom is within the normative values. The most illuminated workplaces are located in a row near the windows due to the direct location of the lamps above the tables (from 501 lx to 590 lx). The workplaces in the row against the wall (from 500 lx to 514 lx) turned out to be less illuminated. The illumination of the middle row was in the range from 511lx to 533 lx. The obtained results of the actual illumination generally correlate with the results of the DIALux simulation, but the measured illumination in all areas turned out to be 10 % lower on average than the program calculated. This is due to the fact that the luminous flux of fluorescent lamps decreases during operation due to the aging of lamps, degradation of phosphor, and other factors. The established frequency of lamp replacements in classrooms, according to the results of the study, is optimal and allows us to ensure the normative illuminance of workplaces. It is worth noting that the lamps at the time of replacement work out only 50 % of their life and are suitable for use in other rooms that do not require high visual load.
OLED Lighting as a Salutogenic Lighting Design Element in an Indoor Environment
Authors: Avci Ayse Nihan
Published: January 2025

OLED lighting offers many opportunities by considering indoor environmental quality parameters. Considering these opportunities and the needs of the individual, the widespread use of OLED lighting positively impacts social, psychological, physical, and behavioural patterns. Developing a research field on the impact of OLED lighting on an individual’s health and well-being leads to a discussion of the indoor environment from different perspectives. To achieve this, salutogenic design is one of the techniques to assess indoor OLED lighting from various perspectives. In recent years, salutogenic design has become increasingly prominent in architectural and interior design. This approach emphasizes promoting health and well-being rather than only concentrating on preventing and treating sickness. This study assesses the application of OLED lighting in the context of salutogenic lighting design. The evaluation focuses on the impact of OLED lighting in an indoor environment and its potential contributions to individuals’ overall health and well-being regarding its compatibility with salutogenic design principles. Through a comprehensive review of existing literature and research, this study explores various aspects of OLED lighting, including its effects on health and well-being, energy efficiency, and environmental sustainability, within the context of salutogenic lighting design.
The Influence of “Green” Roofs on the Heat Island of Urban Agglomerations
Authors: Sysoeva Elena V.
Published: January 2025

The sun has both positive and negative effects on humans. Excessive amounts of ultraviolet rays lead to skin aging, skin cancer, burns, heat and sunstroke, and other diseases that can lead to death. On the other hand, it is the sun that is necessary for the synthesis of vitamin D. Therefore, it is necessary to properly dose the insolation, while using energy-efficient and environmentally friendly methods.
The article provides an analysis of maps with isolines of the same temperatures inside Moscow. Based on these studies, a conclusion is made about the type of buildings that have the greatest impact on the city’s thermal island. There is evidence of a global increase in temperature on the Planet by (2–3) 0C, which, according to IPCC experts, can lead to collapse. In the last century, the percentage of the urban population, the built-up area of urban agglomerates, the height of buildings, and the density of buildings have increased dramatically. The percentage of rural settlements has become less than 34 % in Russia, which leads to an increase in the speed of construction. The use of building materials such as asphalt, concrete, glass, etc. has led to the formation of urban heat islands, especially in the construction sites of large community centres. Forecasters, urban planners, and civil engineers are thinking about possible solutions to this problem.
The article describes the quantitative assessment of the thermal island effect using the index, possible environmentally friendly and energy-efficient methods of reducing the thermal island effect through the use of additional compensatory landscaping at various levels of the building.
Each of the methods of reducing the temperature of the city is illustrated with examples of photos from Russia and around the world.
Oocyte Freezing Following Ovulation Induction and Egg Retrieval in a 45x Teenage Girl with Hypergonadotropic Primary Amenorrhea, Estrogen Deficiency, and Sexual Infantilism
Authors: Check Jerome H , Neumann Brooke A , Horwath Danya , Summers Donna
Published: January 2025

Although there have been some uncommon cases of spontaneous ovulation and even pregnancies in females with Turner’s syndrome, most have been Turner mosaics, but some do have the 45x karyotype. However, in all cases these women had normal sexual development. There are techniques to restore sensitivity of follicles to FSH by up-regulating down regulated FSH receptors. This technique was tried on a 13-year-old with 45X Turner’s syndrome with markedly elevated serum FSH, very low serum estradiol (E2) and sexual infantilism with the intent of banking an egg or two for future fertility purposes. Despite bilateral streaked gonads, she made a dominant follicle twice, once at age 13 and once at age 14. One egg was retrieved from each IVF cycle. The first egg was cryopreserved for the future whereas the second egg was discarded because it was degenerating. Thus, the FSH receptor up-regulation technique can even allow follicle maturation despite barely any ovarian tissue remaining on the urogenital ridges Possibly, once considering the pros and cons, if the parents and child wanted to bank eggs despite Turner’s syndrome, this should be considered at the youngest age possible.
The Effects of Nanotechnology and Theranostic on Neurodegenerative Diseases
Authors: Otero Marelis Molina , Sneed Kevin B , Pathak Yashwant V
Published: January 2025

Nanotechnology and nanomedicine have significantly advanced diagnostics and treatments for life-threatening and disabling diseases. Nanoparticle properties and characteristics are the most impactful force in medicine. Their size, shape, charge, surface area, solubility, and many other properties are substantial in diagnosing and treating. Their size and surface area are inversely proportional to each other. In other words, the smaller the size, the higher the surface area. Thus, their dose is less, better penetration, solubility, bioavailability, point-specific location, fewer side effects, and less toxicity.

Nanoparticles have opened new potential for diagnosis and treatment of neurodegenerative disorders. Neurodegenerative disorders affect the central nervous system (CNS) and disrupt communication between neurons vital for motor, sensory, and cognitive processes. The usage of Nanotheranostic has shown advances in the discovery of potential methods that can reduce inflammation, aggregates, and reactive oxygen species (ROS). Lastly, it is expected that there will be more usage of nanoparticles to detect and treat neurodegenerative disorders like Alzheimer’s and Parkinson’s.
Acute Severe Mitral Valve Regurgitation with Posterior Leaflet Torn Post Motor Vehicle Accident: A Case Report and Review
Authors: Musalem Hebah , Alrubayan Fahad , Almalki Yazeed , Arabi Yaseen , Aljizeeri Ahmad
Published: January 2025

Cardiac injuries are rare complications after blunt chest trauma, and when encountered, myocardial contusions and aortic valve involvement account for most of these injuries. Nevertheless, acute severe mitral valve regurgitation due to a torn leaflet is an infrequently reported life-threatening type of injury in the literature. Hereby, we present a case of acute severe mitral regurgitation post-blunt chest trauma in MVA, highlighting the ICU role in early detection and prompt pharmacological management to prevent heart failure until surgical correction ensues.
The Essence of the mılıtary strategy of the Nıkol Pashınyan government
Authors: Najafov Zafar N.
Published: January 2025

Purpose: The study aims to examine the theoretical and conceptual aspects of the militarization policy implemented by the Pashinyan government in Armenia in the last 5 years.
Method: historical, political, structural-functional and comparative analysis methods.
Findings: The results are that the revanchism that took place in Armenia, which suffered a heavy defeat in the Second Karabakh War, created the basis for the rearming of the country, the diversification of its foreign policy course and military security. Armenia is trying to compensate for that defeat by turning the region into a wider conflict zone (West-Russia).
Paper type: theoretical.
Теоретичні підходи до визначення поняття «організаційно-економічний механізм»
Authors: Bondarenko Yuliia
Published: January 2025

Мета роботи: є удосконалення поняття організаційно-економічного механізму забезпечення розвитку економіки України.
Метод дослідження: аналіз та порівняння, нормативний метод.
Результати дослідження: Визначення поняття “організаційно-економічний механізм”.
Теоретичні висновки: полягає у формуванні цілісного уявлення про сучасні підходи до формування поняття “організаційно-економічний механізм”, що забезпечує регулювання організаційно-технічних, виробничо-технологічних, фінансово-економічних процесів та відносин з метою забезпечення розвитку економіки держави.
Практична цінність дослідження: виявлені деяких помилки і неточності при формуванні поняття “організаційно-економічний механізм”, а саме: 1) не враховують корінні причини здійснення економічної діяльності, такі як бажання задовольнити певні потреби ринку та необхідність урахування конкурентного середовища; 2) не враховують мету, спрямованість цієї послідовності дій і методів на встановлення взаємодії окремих елементів системи; 3) не враховують інструменти досягнення бажаних результатів; 4) підмінюють складові механізму цілями та функціями, що не завжди дозволяє виокремити недоліки в управлінні, з метою розробки заходів щодо їх усунення; 5) обмежують кількість методів, що включають до понятійного апарату; 6) відображають процес забезпечення розвитку економіки і засобів здійснення цього процесу без розкриття терміну “механізм”.
Тип статті: теоретичний.
Можливості та виклики використання мобільних платежів і банкінгу для відновлення економіки України
Authors: Zadvornyi Iurii
Published: January 2025

Мета роботи: дослідження можливостей і викликів впровадження мобільних платежів та банкінгу для забезпечення економічної стабільності та відновлення економіки України в умовах війни та в післявоєнний період.
Дизайн/Метод/Підхід дослідження: статистичний аналіз, емпіричний аналіз, кейс-стаді, якісний аналіз, теоретичний аналіз, системний аналіз.
Результати дослідження: узагальнено аналітичні дані, що необхідні для формування рекомендацій щодо впровадження мобільних платежів і банкінгу як інструментів економічної стабілізації та відновлення України. Запропоновано заходи для фінансових установ, державних органів та міжнародних партнерів, спрямовані на підвищення доступності фінансових послуг, оптимізацію їх використання в умовах кризи та інтеграцію сучасних технологій у фінансову систему країни.
Теоретична цінність дослідження: дослідження допоможе поглибити розуміння ролі мобільних платежів і банкінгу в умовах економічної нестабільності, викликаної військовими конфліктами, зокрема, їх впливу на фінансову інклюзію, підтримку малого і середнього бізнесу, а також інтеграцію інноваційних технологій у фінансову систему країни.
Практична цінність дослідження:  результати дослідження можуть бути використані урядовими інституціями, фінансовими установами та міжнародними організаціями для розробки стратегій впровадження мобільних платежів і банкінгу, спрямованих на забезпечення економічної стабільності, підтримку малого та середнього бізнесу, розширення доступу до фінансових послуг та відновлення економіки України в повоєнний період.
Оригінальність/Цінність дослідження:  полягає у здійсненні аналізу та розробці рекомендацій, які можуть бути використані урядом, фінансовими установами та міжнародними організаціями для впровадження мобільних платежів і банкінгу як інструментів економічної стабілізації, підтримки фінансової інклюзії та відновлення економіки України в умовах кризи та у післявоєнний період.
Обмеження дослідження/Майбутні дослідження: обмеження дослідження полягає у використанні даних, доступних із відкритих джерел, та відсутності деталізованої інформації від фінансових установ щодо специфіки впровадження мобільних платежів і банкінгу в кризових умовах. Майбутні дослідження будуть спрямовані на аналіз практичного досвіду використання цих технологій для економічного відновлення в Україні та інших країнах, які пережили війну.
Тип статті: теоретичний, практичний.
Підвищення ефективності Row-Sampling методів для захисту від атак типу Row-Hummer
Authors: Mazurok Valentyn , Lutsenko Volodymyr
Published: January 2025

Мета роботи: провести аналіз захисту систем від атак типу RowHammer на основі методу вибірки рядків та запропонувати її покращення використовуючи більш реалістичну модель пам’яті та модель атаки.
Результати дослідження: показано недоліки в представленні пам’яті в захисних механізмах на основі вибірки рядків та показано більш коректні способи обчислення порогу вибірки. Результати представлено на реальних прикладах покращення захисту пам’яті DRAM.
Практична цінність дослідження: Знайдені формули можуть значно покращити захищеність нових видів пам’яті DRAM від атак типу Rowhammer.
Цінність дослідження: представлено дані тестування нових чіпів пам’яті кількох виробників DRAM. Також представлено нові види обрахунку порогових значень для захисту від RowHammer.
Майбутні дослідження: це дослідження відкриває шляхи для покращення програмних методів захисту від RowHammer а також пропонує розробку технічних засобів для комбінацій з програмними рішеннями.
Mediation as an Alternative to Legal Dispute Resolution in Health Services in Hospitals
Authors: Perangin-Angin Thimothy Aryadi , Lamria Sintia Silaban  , Sonya Airini Batubara  , Jusnizar Sinaga
Published: January 2025

This research aims to analyze the role of mediation as a method of medical dispute resolution in Indonesia, which is seen as more effective, fair, and cost-effective than the litigation process. This research uses a normative legal method with a descriptive-analytical approach to identify legal principles, doctrines, and regulations related to medical dispute resolution. The main focus is dispute resolution through mediation in medical malpractice cases, which involves civil, criminal, and restorative justice aspects. The novelty of this research lies in the in-depth exploration of penal mediation as an approach in resolving criminal disputes related to medical malpractice, even though it does not yet have a strong legal foundation in the Indonesian criminal justice system. The results show that mediation, both in the civil and criminal realms, can provide a more humane and satisfying solution for all parties involved. However, the implementation of penal mediation still faces legal and practical challenges, especially in providing protection of patients' rights and ensuring justice for medical personnel.In conclusion, mediation has great potential in resolving medical disputes in Indonesia, but more specific regulations are needed to optimize its implementation, especially in criminal cases. As such, this study makes an important contribution to the development of a better medical dispute resolution mechanism in Indonesia.
Implementasi Kepemimpinan Transformasional di SD Negeri Ploso
Authors: Putri Magda Ilona Dwi , Roesminingsih Erny , Setyowati Sri
Published: January 2025

School is an educational institution whose job is to provide public services. Schools can survive and develop if the educational leadership function is carried out by the principal properly. Educational leadership is essential in educational institutions. The ideal leader is able to bring the institution he leads to progress. One style of leadership that is able to motivate its members is transformational leadership. Transformational leadership has four criteria, namely having charisma, inspiring, caring, and being able to stimulate the minds of their subordinates. This study uses a descriptive qualitative approach. This study aims to describe the implementation of transformational leadership at SD Negeri Ploso. The results of the study show that transformational leadership is able to create innovation for education at SD Negeri Ploso. SD Negeri Ploso makes a morning habitual policy, namely chanting asmaul husna, dhuha prayers, and reading short letters for Muslim students. While Christian students carry out habituation in the form of morning worship. The implementation of this transformational leadership is able to increase public trust in SD Negeri Ploso as evidenced by an increase in the number of new students in the 2024/2025 academic year
Desa Cerdas Ramah Gender: Analisis Penerapan Sertifikasi Halal dan Komersialisasi Produk Bagi Pelaku UMKM Perempuan
Authors: Fawaid Achmad , Abdullah Abdullah
Published: January 2025

Gagasan desa cerdas (smart village) menjadi instrumen fundamental dalam kerangka kebijakan Kementerian Desa, Pembangunan Daerah Tertinggal, dan Transmigrasi (Kemendes PDTT) Republik Indonesia. Namun, bagaimana gagasan ini diintegrasikan dengan program sertifikasi halal dan komersialisasi produk lokal untuk mendorong pembangunan desa yang ramah gender di level mikro masih kurang mendapat perhatian. Penelitian ini bertujuan untuk menganalisis penerapan smart village ramah gender di kawasan industri pinggiran tol Jawa melalui sertifikasi dan komersialisasi produk lokal. Intervensi dilakukan secara khusus di Clarak, sebuah desa di pinggiran kota Kabupaten Probolinggo, yang berdekatan langsung dengan tol Probowangi. Studi kasus yang melibatkan 30 pelaku UMKM perempuan, berfokus pada bagaimana sertifikasi halal dan komersialisasi produk dapat meningkatkan partisipasi mereka dalam kerangka Desa Cerdas Ramah Gender (DCRG). Penelitian ini mengidentifikasi setidaknya 6 (enam) aset yang dimiliki oleh Clarak dalam menginisiasi desa cerdas ramah gender, yaitu aset individual, aset fisik, aset kelembagaan, aset jaringan, aset ekonomi lokal, dan aset historis. Hasil penelitian juga menunjukkan bahwa terdapat peningkatan partisipasi perempuan sebagai penerima manfaat dari program ini sekaligus peningkatan pengetahuan digital terhadap komersialisasi produk lokal. Penelitian ini berkontribusi bagi penelitian sejenis yang berusaha memahami bagaimana konsep desa cerdas diinisiasi di level mikro, khususnya di kawasan industri.
ATTITUDES OF TEACHING STAFF TOWARDS INCLUSION AND OF STUDENTS TOWARDS THE INCLUSION OF PEERS WITH SPECIAL EDUCATIONAL NEEDS IN THE CLASSROOM
Authors: KOŽÁROVÁ JANA , HNÁTOVÁ MIROSLAVA , ŽOLNOVÁ JARMILA
Published: January 2025

The inclusion of the school environment is an indicator of the humanisation of this environment and of society as a whole. The evaluation of the attitudes of all school actors is a good indicator of it. The aim of this paper is to map the attitudes of teaching staff and intact students towards pupils with special educational needs in schools. The present paper argues through two sets of research - teaching staff and intact students - for positive developments in creating inclusive school environments in primary schools.
CRISIS INTERVENTION AS ONE OF THE FACTORS OF CREATING SAFE SCHOOL ENVIRONMENT
Authors: EMMEROVÁ NGRID , JABLONSKÝ TOMÁŠ
Published: January 2025

School, as an important educational and socializing factor, should be a safe environment. The safety of the school environment is crucial to ensuring quality education and the protection of both pupils and all school staff. The study deals with crisis intervention in schools, which is one of the factors creating safe school environment. Crisis intervention at schools takes place in the area of solving pupils' as well as teachers' problems, helping in overcoming specific obstacles. It seeks to help pupils or teachers, to create a safe space, to activate sources of support and to focus on restoring one's own strength.
ENHACING CRITICAL THINGKING THROUGH PROBLEM BASED LEARNING IN ISLAMIC EDUCAITON
Authors: Sukardi Ahmad , Kholilurrohman Kholilurrohman , Hidayah Fathi , Hussen Bannaga Taha Elzubair
Published: January 2025

This research focused on evaluating the effectiveness of Problem-Based Learning (PBL) within the context of Islamic religious education at High School. A qualitative case study approach was used, with data collected from in-depth interviews with 20 participants, participatory observations, and analysis of curriculum documents. Data were collected through a series of in-depth interviews, participatory observations, and analysis of the curriculum documents used at the school. The findings indicate that PBL supports students not only in understanding theoretical religious concepts but also in applying these values practically in their daily lives. Moreover, this method has proven to enhance students' learning motivation and analytical abilities. This study offered concrete guidelines for integrating PBL into Islamic education curricula and suggests further research across different schools to assess generalizability. The implications of this study were highly relevant for the development of a more innovative and responsive curriculum to modern educational needs.
Niat Ibu Memberi ASI Eksklusif Berdasarkan Theory of Planned Behavior
Authors: Marisa Silva , Bratajaya Cicilia Nony Ayuningsih
Published: January 2025

Cakupan ASI Eksklusif di Indonesia belum mencapai target yang ditetapkan. Salah satu yang menentukan keberhasilan ibu memberikan ASI eksklusif adalah niat. Studi penelitian ini mengidentifikasi faktor yang berhubungan dengan niat ibu memberi ASI eksklusif berdasarkan teori perilaku terencana (Theory of Planned Behavior, TPB). Penelitian kuantitatif ini menggunakan desain cross-sectional. Populasi penelitian adalah ibu yang mempunyai bayi 0-6 bulan. Teknik purposive sampling digunakan pada sampel berjumlah 124 responden. Kuesioner penelitian dibuat berdasarkan TPB. Hasil studi ini mengungkap mayoritas ibu mempunyai niat kuat untuk memberi ASI eksklusif sebanyak 107 responden (86,3%). Hasil analisis data menggunakan Kendall’s Tau B menunjukkan ada hubungan antara sikap (p-value = 0,000; p < 0,05) dan kontrol persepsi yang dirasakan (p-value = 0,000; p < 0,05) dengan niat ibu memberi ASI eksklusif. Namun, norma subjektif dan niat ibu memberikan ASI eksklusif tidak berhubungan (p value = 0,723; p < 0,05). Maka, penting bagi tenaga kesehatan untuk meningkatkan kesadaran ibu memberikan ASI eksklusif pada kegiatan promosi kesehatan dan penyediaan fasilitas menyusui dirasa perlu untuk mendukung peningkatan pemberian ASI eksklusif.
Intervensi Akupresur untuk Neuropati Perifer pada Diabetes Melitus dengan Sindrom Lembab Limpa: Studi Kasis dan Literatur Review
Authors: Sujati Ni Ketut , Akbar M Agung , Anggraeni Hesti , Fadhillah Laila
Published: January 2025

Sindrom lembab limpa (Pi Xu Re Yang) yang ditandai dengan gangguan sirkulasi dan metabolisme cairan memperburuk komplikasi neuropati perifer, penyakit arteri perifer, dan infeksi pada pasien diabetes yang dapat menyebabkan amputasi ekstremitas. Perkembangan ulkus kaki diabetik dan kerusakan saraf lebih lanjut dapat dicegah dengan perawatan sirkulasi dan terapi akupresur yang dapat menjaga sirkulasi darah ke ekstremitas. Tujuan studi kasus ini untuk menggambarkan penerapan perawatan sirkulasi kombinasi akupresur pada pasien diabetes dengan sindrom lembab limpa. Studi kasus ini dilakukan selama tiga kunjungan dalam tiga minggu, menggunakan metode penerapan perawatan kaki, senam kaki, spa kaki dan pemilihan alas kaki yang dikombinasikan dengan teknik akupresur pada meridian tertentu pada 2 pasien diabetes. Hasil yang dicapai berupa menurunnya keluhan kesemutan, mati rasa, dan warna kulit pucat, meningkatnya kekuatan nadi perifer, serta membaiknya pengisian kapiler dan turgor kulit. Hal ini menunjukkan bahwa perawatan sirkulasi kombinasi akupresur mampu menurunkan skor neuropati dari kategori risiko rendah menjadi risiko sangat rendah. Studi kasus menunjukkan penerapan sirkulasi kombinasi akupresur berhasil memperbaiki perfusi perifer. Penelitian selanjutnya disarankan untuk melakukan pengukuran sirkulasi menggunakan metode Ankle-Brachial Index (ABI) dan doppler guna mendapatkan evaluasi yang akurat.
Faktor-faktor yang Berhubungan dengan Kejadian Stunting pada Bayi Usia 24-35 Bulan
Authors: Saragih Kristiova Masnita , Wahyunita Vina Dwi
Published: January 2025

Stunting balita dapat disebabkan karena adanya faktor risiko dan komplikasi kehamilan. Dalam konteks nasional dan global, masalah ini dapat mengganggu produktivitas dan kualitas sumber daya manusia di masa mendatang. Memeriksa adanya korelasi faktor-faktor yang berhubungan dengan stunting bayi usia 24-35 bulan adalah tujuan dari penelitian ini. Penelitian ini menggunakan desain cross-sectional berdasarkan analitik observasional. Partisipan adalah ibu-ibu yang tinggal di sekitar Puskesmas Saumlaki yang melahirkan batita. Total sampel berjumlah 70 ibu dengan variabel-variabel berikut: usia, usia kehamilan, status gizi ibu, penghasilan, pendidikan, pengetahuan. Uji Chi-Square digunakan untuk menganalisis data penelitian ini. Metode untuk mengumpulkan informasi meliputi survei dan observasi yang cermat. Penelitian ini menemukan bahwa kejadian stunting pada bayi usia 24-35 bulan memiliki korelasi dengan faktor-faktor seperti usia ibu <20 tahun (p 0,001), riwayat usia kehamilan antara 20-36 minggu (p <0,001), tingkat pendidikan rendah (p <0,001), tingkat penghasilan rendah (p <0,001), kurangnya pengetahuan (p <0,001), dan status gizi ibu (p <0,001). Petugas kesehatan perlu memberikan pendidikan kesehatan tentang bahaya kehamilan berisiko stunting pada batita seperti hamil di usia dini, hamil prematur, dan status gizi ibu.
Spatial Analysis of Immunization Coverage in Serang Regency, Indonesia in 2021
Authors: Fitri Laelatul , Makful Martya Rahmaniati
Published: January 2025

The incidence of deaths of children under five years of age in low- and middle-income countries due to imperfect immune system was estimated to increase, which actually can be prevented and reduced by immunization. In 2021, Banten Province received the highest immunization rating in Indonesia with coverage of 94.8%. However, in its Serang Regency, complete basic immunization coverage was only 89.2%. The aim of this study was to find out the spatial distribution of complete immunization coverage in Serang Regency, Banten Province, Indonesia in 2021. This research used an ecological study design with spatial analysis to estimate and analyze the distribution of immunization coverage in 29 districts in Serang Regency by looking at the number of integrated health post (Ina. posyandu) and the number of midwives spread across them. The analysis results showed a negative spatial autocorrelation of immunization coverage in Serang Regency in 2021. There was 1 district included in quadrant II (low-high), namely Bandung District and 1 district included in quadrant IV (high-low), namely Padarincang District.
Upaya Pekerja Seks Komersial Lokalisasi Daerah Pesisir dan Perbatasan dalam Mencegah Penularan HIV AIDS: Studi Fenomenologi
Authors: Parman Dewy Haryanti , Waluyo Agung , Yona Sri , Wispriyono Bambang
Published: January 2025

Kasus HIV AIDS terus meningkat setiap tahun. Pada tahun 2023 dari 1.414 kasus HIV AIDS di Kalimantan Utara, Indonesia, 500 kasus ada di wilayah Tarakan. Penelitian ini bertujuan mengungkapkan situasi sejauh mana upaya pekerja seks komersil (PSK) dalam mencegah penularan HIV AIDS di daerah pesisir dan perbatasan Tarakan. Penelitian ini bersifat kualitatif dengan pendekatan deskriptif fenomenologi. Penelitian ini melibatkan 15 partisipan PSK di lokalisasi daerah Tarakan. Analisis data menggunakan analisis tematik oleh Braun dan Clarke. Penelitian ini menghasilkan empat tema, yaitu: (1) pemeriksaan kesehatan dilakukan secara tidak rutin, (2) pelanggan yang menolak menggunakan kondom tetap dilayani, (3) penggunaan antibiotik untuk mencegah penularan HIV AIDS, dan (4) membatasi pelanggan. Pencegahan Penularan HIV AIDS oleh PSK belum maksimal karena adanya latar belakang keterbatasan ekonomi dan kemampuan negosiasi serta kurangnya pemahaman tentang penyakit HIV AIDS. Pendekatan edukasi yang lebih komprehensif dibutuhkan untuk meningkatkan kesadaran akan pentingnya menjaga diri dari pencegahan penyakit menular agar mereka dapat bekerja dalam jangka waktu lama.
Aplikasi Pemberian Minuman Sereh Madu (Serdu) sebagai Pengembangan Fitofarmaka dalam Mengatasi Hipertensi pada Wanita
Authors: Rahayu Trio Gustin , Khotimah Husnul
Published: January 2025

Terapi herbal rebusan air sereh dan madu menjadi salah satu alternatif pengobatan dalam menurunkan tekanan darah. Penelitian ini bertujuan untuk mengetahui efektivitas dari terapi herbal sereh madu (serdu) terhadap hipertensi pada wanita. Desain penelitian menggunakan pre eksperimen one group pre test post test. Penelitian dilakukan di Kota Serang Provinsi Banten yaitu di wilayah kerja Puskesmas Singandaru dengan sampel 25 responden. Teknik pengambilan sampel adalah quota sampling. Data dianalisis menggunakan Wilcoxon signed rank test dengan tingkat kemaknaan yaitu 95% (α 0,05). Hasil penelitian menunjukkan bahwa pada hari ke-7 pemberian minuman herbal sereh madu (serdu) dapat menurunkan rerata tekanan darah sistol  sebesar 18 mmHg (p value <0,001) dan tekanan darah diastol sebesar 8 mmHg (p value <0,001). Sebuah pilihan alternatif untuk pengobatan hipertensi wanita adalah minuman sereh madu. Namun, penelitian lebih lanjut diperlukan untuk memastikan bahwa minuman sereh madu efektif dan aman dalam jangka panjang, terutama untuk ibu yang menderita kondisi medis tertentu.
Nanodiamond-mediated delivery of microRNA-7 for the neuroprotection of dopaminergic neurons
Authors: Han Yuping , Yao Yue , Wen Xinyi , Wang Hao , Li Shurong , Su Bingyin
Published: January 2025

Parkinson’s disease (PD) is a neurodegenerative disorder characterized by the gradual loss of dopaminergic neurons in the substantia nigra and the accumulation of α-synuclein aggregates known as Lewy bodies. MicroRNA-7 (miR-7) targets the gene SNCA, which encodes α-synuclein, reducing its expression and alleviating neuronal damage in PD. Regulating the post-transcriptional levels of α-synuclein through miR-7 effectively inhibits its production. Herein, we use nanodiamonds as carriers to deliver miR-7 (N-7), which can effectively protect dopaminergic neurons. Dopaminergic neurons efficiently take up N-7 and express miR-7. N-7 inhibits the expression of α-synuclein, reduces oxidative stress and restores dopamine levels effectively. These findings suggest that nanocomposites have significant potential in treating PD.
Effects of different microfracture drilling parameters on bone quality: a finite element analysis
Authors: Luo Jiayi , Zou Zihao , Zou Qiang , Luo Siwei , He Jialin , Ye Chuan
Published: January 2025

Background

Microfracture drilling is a surgical technique that involves creating multiple perforations in areas of cartilage defects to recruit stem cells from the bone marrow, thereby promoting cartilage regeneration in the knee joint. Increasing the exposed bone marrow surface area (more holes in the same area) can enhance stem cell outflow. However, when the exposed area is large, it may affect the mechanical strength of the bone at the site of the cartilage defect. The purpose of this study is to use the finite element method to analyze the effects of drilling diameter, hole spacing, and drilling depth during microfracture surgery on the stability of the bone structure at the cartilage defect site.

Methods

In this study, a normal knee joint model was selected for solid modeling, and a model of a femoral medial condyle cartilage defect was constructed. Microfracture holes with different diameters (1.0 mm, 2.0 mm, 3.0 mm), depths (10 mm, 30 mm), and spacings (1.0 mm, 2.0 mm, 3.0 mm) were created in the femoral medial condyle cartilage defect model. Using Ansys software, the knee joint’s loading conditions in the standing position were simulated, and the structural stability of the model was analyzed. The holes in areas of stress concentration were selected for more detailed mechanical analysis.

Results

The Von Mises stresses for all the drilling parameters did not exceed the yield strength of the bone. Changes in the drilling parameters did not affect the bone structure around the holes. When smaller diameter drilling tools with closer spacing were used, the average maximum Von Mises stress and the average Von Mises stress on the holes were the lowest.

Conclusion

Although the optimal combination of drilling parameters was not determined, this study provides a mechanical reference for the effects of drilling parameters on bone quality. It demonstrates that using smaller diameter drilling tools with closer spacing in areas of the same defect size results in a greater number of holes, with a lesser impact on bone stability. This study provides a mechanical reference for microfracture drilling.
Cross-cutting effect of type 2 diabetes on the sensorimotor control of balance
Authors: Lopatin Trevor , Borngesser Ben , Haworth Joshua
Published: January 2025

Type 2 Diabetes is a highly prevalent chronic disorder that affects multiple systems through microvascular complications. Complications such as diabetic peripheral neuropathy, diabetic retinopathy, and diabetic vestibular dysfunction (vestibulopathy) all directly interfere with the sensory components of balance and postural stability. The resulting impairments cause increased falls risk and instability, making it difficult to perform daily task or exercise. This commentary will provide clarity on the causes and relationship between the sensory complications of T2D, balance, and excise, while also providing recommendations and precautions for exercising with one of these sensory complications.
Study on gene expression in the liver at various developmental stages of human embryos
Authors: Chen Hanqing , Li Tingting , Cai Ming , Huang Zhiqi , Gao Jianjun , Ding Hongping , Li Minmin , Guan Weiyu , Chen Jinpeng , Wang Wenran , Li Chunhong , Shi Jianwu
Published: January 2025

Background

The normal development of the liver during human embryonic stages is critical for the functionality of the adult liver. Despite this, the essential genes, biological processes, and signal pathways that drive liver development in human embryos remain poorly understood.

Methods

In this study, liver samples were collected from human embryos at progressive developmental stages, ranging from 2-month-old to 7-month-old. Highly expressed genes and their associated enrichment processes at various developmental stages of the liver were identified through transcriptomic sequencing.

Results

The findings indicated that genes associated with humoral immune responses and B-cell-mediated immunity were highly expressed during the early developmental stages. Concurrently, numerous genes related to vitamin response, brown adipocyte differentiation, T cell differentiation, hormone secretion, hemostasis, peptide hormone response, steroid metabolism, and hematopoietic regulation exhibited increased expression aligned with liver development. Our results suggest that the liver may possess multiple functions during embryonic stages, beyond serving hematopoietic roles. Moreover, this study elucidated the complex regulatory interactions among genes involved in lymphocyte differentiation, the regulation of hemopoiesis, and liver development. Consequently, the development of human embryonic liver necessitates the synergistic regulation of numerous genes. Notably, alongside conventionally recognized genes, numerous previously uncharacterized genes involved in liver development and function were also identified.

Conclusion

These findings establish a critical foundation for future research on liver development and diseases arising from fetal liver abnormalities.
A multi-modal multi-branch framework for retinal vessel segmentation using ultra-widefield fundus photographs
Authors: Xie Qihang , Li Xuefei , Li Yuanyuan , Lu Jiayi , Ma Shaodong , Zhao Yitian , Zhang Jiong
Published: January 2025

Background

Vessel segmentation in fundus photography has become a cornerstone technique for disease analysis. Within this field, Ultra-WideField (UWF) fundus images offer distinct advantages, including an expansive imaging range, detailed lesion data, and minimal adverse effects. However, the high resolution and low contrast inherent to UWF fundus images present significant challenges for accurate segmentation using deep learning methods, thereby complicating disease analysis in this context.

Methods

To address these issues, this study introduces M3B-Net, a novel multi-modal, multi-branch framework that leverages fundus fluorescence angiography (FFA) images to improve retinal vessel segmentation in UWF fundus images. Specifically, M3B-Net tackles the low segmentation accuracy caused by the inherently low contrast of UWF fundus images. Additionally, we propose an enhanced UWF-based segmentation network in M3B-Net, specifically designed to improve the segmentation of fine retinal vessels. The segmentation network includes the Selective Fusion Module (SFM), which enhances feature extraction within the segmentation network by integrating features generated during the FFA imaging process. To further address the challenges of high-resolution UWF fundus images, we introduce a Local Perception Fusion Module (LPFM) to mitigate context loss during the segmentation cut-patch process. Complementing this, the Attention-Guided Upsampling Module (AUM) enhances segmentation performance through convolution operations guided by attention mechanisms.

Results

Extensive experimental evaluations demonstrate that our approach significantly outperforms existing state-of-the-art methods for UWF fundus image segmentation.
Challenges in “probing spectroscopic probes” for noninvasive simultaneous disease diagnosis
Authors: Roy Lopamudra , Paul Shweta , Banerjee Amrita , Ghosh Ria , Mondal Susmita , Das Monojit , Pan Nivedita , Das Ishitri , Singh Soumendra , Bhattacharya Debasish , Mallick Asim Kumar , Pal Samir Kumar
Published: January 2025

Noninvasive diagnosis of human diseases relies on the detection of molecular markers (probes) in a painless manner. Although extrinsic and intrinsic molecular markers are often used, intrinsic disease probes (molecular markers) are preferable because they are naturally present in our body, and deviation in their concentration from normal levels clearly indicates anomalies in human bodies, that is, diseases. In this study, we report noninvasive spectroscopic measurements of total haemoglobin (Hb), bilirubin, and the ratio of oxy- and deoxyhaemoglobin as disease markers for anaemia, jaundice, and oxygen deficiency, respectively, using a meticulously designed optical fibre probe. The challenges in designing the fibre probe for simultaneous noninvasive detection, including optical power, spectral density of the probing light, and resolution of the spectrometer, were found to be critical to accurate measurements. Finally, a fibre-less, highly portable, and low-cost prototype was developed and tested in human clinical trials for the diagnosis of diseases, and these results were compared with conventional techniques (blood tests).
Genetic insights into MIS-C Post-COVID-19 in Kuwaiti children: investigating monogenic factors
Authors: Dashti Mohammed , AlKandari Hessa , Malik Md Zubbair , Nizam Rasheeba , John Sumi Elsa , Jacob Sindhu , Channanath Arshad , Othman Fouzeyah , Al-Sayed Safa , Al-Hindi Osama , Al-Mutari Mona , Thanaraj Thangavel Alphonse , Al-Mulla Fahd
Published: January 2025

Background

Multisystem inflammatory syndrome in children (MIS-C) is a severe complication arising from SARS-CoV-2 infection, with indications that rare inborn errors of immunity may play a role in its pathogenesis. Recent studies suggest that genetic predispositions, particularly monogenic forms, could significantly influence the immune responses to SARS-CoV-2 in MIS-C.

Methods

We analysed 24 children under 12 years old, all of whom met the criteria provided by the World Health Organization, 2020 for MIS-C diagnosis, from the Paediatric COVID-19 Registry in Kuwait (PCR-Q8). Demographic and clinical data were collected from medical records, and exome sequencing was performed on the children and their parents to identify rare exonic variants. These variants were prioritized using two approaches: a candidate genes approach employing trio segregation analysis, and a candidate variants approach using a gene panel informed by previous studies on MIS-C-related genetic variants and datasets of differentially expressed genes in MIS-C patients.

Results

The candidate genes approach identified 53 unique genes in 20 of the 24 probands, including DDX60 and TMEM154, which were also differentially expressed between MIS-C and control groups. The candidate variants approach identified 33 rare, predicted deleterious heterozygous variants across 19 unique genes in 19 of the 24 probands, including both previously described and novel candidate variants for MIS-C. Pathway analysis of the identified genes from both approaches revealed significant involvement in immune response, viral defence, and inflammatory pathways.

Conclusion

This study underscores the monogenic susceptibility to MIS-C, enhancing the evidence base through comprehensive genetic analysis. The findings highlight the critical role of genetic predispositions in MIS-C and suggest that further functional genomics work is necessary to explore the mechanistic contributions of these genes, facilitating the development of targeted diagnostic strategies.
Ectophoma salviniae sp. nov., Neottiosporina mihintaleensis sp. nov. and four other endophytes associated with aquatic plants from Sri Lanka and their extracellular enzymatic potential
Authors: Wimalasena Madhara K. , Wijayawardene Nalin N. , Bamunuarachchige Thushara C. , Zhang Gui-Qing , Udeni Jayalal R. G. , Bhat Darbhe J. , Dawoud Turki M. , de Zoysa Heethaka K. S. , Dai Dong-Qin
Published: January 2025

Endophytic fungi associated with selected aquatic plants, Eichhornia crassipes, Nymphaea nouchali, Salvinia minima and S. molesta were evaluated. Ectophoma salviniae sp. nov. and Neottiosporina mihintaleensis sp. nov. are introduced as novel taxa from Salvinia spp. from Sri Lanka. Chaetomella raphigera is reported as a new geographical record, Colletotrichum siamense and C. truncatum are reported as novel host records in aquatic plants, while Phyllosticta capitalensis has been identified on the same host (Nymphaea nouchali) in the North-Central Province of Sri Lanka. Identification of the fungi was based on morphological characteristics and multi-locus phylogenetic analyses using ITS, LSU, SSU, ACT, CHS-1, GAPDH, tub2, rpb2, and tef1-α molecular markers. The identified fungi were analysed for extracellular enzymatic properties. According to the qualitative analysis, Ectophoma salviniae sp. nov. exhibited the highest amylase production, Chaetomella raphigera exhibited the highest cellulase enzyme production, and Neottiosporina mihintaleensis sp. nov. exhibited the highest laccase production. The results demonstrate the aquatic fungal diversity in this region and their extracellular enzymatic potentials, providing valuable insights for future biotechnological approaches.
Language usage during shared reading—family communication as implicit plurilingual family language policy
Authors: Dillon Anna , Gallagher Kay , Saqr Sumaya , Habak Claudine , AlRamamneh Yahia
Published: January 2025

This brief research report explores the language choices of Emirati fathers when sharing reading with their young children, and discusses how implicit plurilingual family language policies may be expressed through these choices. Participants’ responses were shared via WhatsApp messages following on from workshops provided by the team which offered tips for sharing reading. Fathers’ reported language choices for communicating via shared reading prompted the authors to reflect on these practices and situate them within a larger discussion on plurilingualism and the ways in books may be shared within plurilingual homes. The language choices of Emirati fathers demonstrate a range of implicit family language policies. They allude to translanguaging and plurilingual practices, which become enacted policies within the home. With some children wishing to read in English, others wishing to read in Arabic, some fathers reading in Emirati Arabic and combinations of all of those languages and language varieties, and only a few of them reading the book in the language within which it was originally printed, it seems like a translanguaging stance is being taken for communication within homes, as plurilingual repertoires are being actively harnessed through this shared reading.