bluuebunny/crossref_metadata_2025 huggingface dataset:
Supercontinent Cycle and Thermochemical Structure in the Mantle: Inference from Two-Dimensional Numerical Simulations of Mantle Convection
Authors: Kameyama Masanori , Harada Akari
Published: December 2017

In this study, we conduct numerical simulations of thermochemical mantle convection in a 2D spherical annulus with a highly viscous lid drifting along the top surface, in order to investigate the interrelation between the motion of the surface (super)continent and the behavior of chemical heterogeneities imposed in the lowermost mantle. Our calculations show that assembly and dispersal of supercontinents occur in a cyclic manner when a sufficient amount of chemically-distinct dense material resides in the base of the mantle against the convective mixing. The motion of surface continents is significantly driven by strong ascending plumes originating around the dense materials in the lowermost mantle. The hot dense materials horizontally move in response to the motion of continents at the top surface, which in turn horizontally move the ascending plumes leading to the breakup of newly-formed supercontinents. We also found that the motion of dense materials in the base of the mantle is driven toward the region beneath a newly-formed supercontinent largely by the horizontal flow induced by cold descending flows from the top surface occurring away from the (super)continent. Our findings imply that the dynamic behavior of cold descending plumes is the key to the understanding of the relationship between the supercontinent cycle on the Earth’s surface and the thermochemical structures in the lowermost mantle, through modulating not only the positions of chemically-dense materials, but also the occurrence of ascending plumes around them.
Connecting the Mind–Body Split: Understanding the Relationship between Symptoms and Emotional Well-Being in Chronic Pain and Functional Gastrointestinal Disorders
Authors: Caes Line , Orchard Alex , Christie Deborah
Published: December 2017

Paediatric chronic conditions, e.g., chronic pain and functional gastrointestinal disorders, are commonly diagnosed, with fatigue, pain and abdominal discomfort the most frequently reported symptoms across conditions. Regardless of whether symptoms are connected to an underlying medical diagnosis or not, they are often associated with an increased experience of psychological distress by both the ill child and their parents. While pain and embarrassing symptoms can induce increased distress, evidence is also accumulating in support of a reciprocal relationship between pain and distress. This reciprocal relationship is nicely illustrated in the fear avoidance model of pain, which has recently been found to be applicable to childhood pain experiences. The purpose of this article is to illustrate how mind (i.e., emotions) and body (i.e., physical symptoms) interact using chronic pain and gastrointestinal disorders as key examples. Despite the evidence for the connection between mind and body, the mind–body split is still a dominant position for families and health care systems, as evidenced by the artificial split between physical and mental health care. In a mission to overcome this gap, this article will conclude by providing tools on how the highlighted evidence can help to close this gap between mind and body.
Psychological Distress and Zika, Dengue and Chikungunya Symptoms Following the 2016 Earthquake in Bahía de Caráquez, Ecuador
Authors: Stewart-Ibarra Anna M. , Hargrave Anita , Diaz Avriel , Kenneson Aileen , Madden David , Romero Moory M. , Molina Juan Pablo , Macias Saltos David
Published: December 2017

On 16 April 2016, a 7.8 magnitude earthquake struck coastal Ecuador, resulting in significant mortality and morbidity, damages to infrastructure, and psychological trauma. This event coincided with the first outbreak of Zika virus (ZIKV) and co-circulation with dengue virus (DENV) and chikungunya virus (CHIKV). We tested whether the degree of psychological distress was associated with the presence of suspected DENV, CHIKV, ZIKV (DCZ) infections three months after the earthquake. In July 2016, 601 household members from four communities in Bahía de Caráquez, Manabí Province, Ecuador, were surveyed in a post-disaster health evaluation. Information was collected on demographics, physical damages and injuries, chronic diseases, self-reported psychological distress, and DCZ symptoms. We calculated the prevalence of arbovirus and distress symptoms by community. ANOVA was used to compare the mean number of psychological distress symptoms between people with versus without suspected DCZ infections by age, gender, community and the need to sleep outside of the home due to damages. The prevalence of suspected DCZ infections was 9.7% and the prevalence of psychological distress was 58.1%. The average number of psychological distress symptoms was significantly higher among people with suspected DCZ infections in the periurban community of Bella Vista, in women, in adults 40–64 years of age and in individuals not sleeping at home (p < 0.05). The results of this study highlight the need to investigate the interactions between psychological distress and arboviral infections following natural disasters.
A Polygon and Point-Based Approach to Matching Geospatial Features
Authors: Ruiz-Lendínez Juan , Ureña-Cámara Manuel , Ariza-López Francisco
Published: December 2017

A methodology for matching bidimensional entities is presented in this paper. The matching is proposed for both area and point features extracted from geographical databases. The procedure used to obtain homologous entities is achieved in a two-step process: The first matching, polygon to polygon matching (inter-element matching), is obtained by means of a genetic algorithm that allows the classifying of area features from two geographical databases. After this, we apply a point to point matching (intra-element matching) based on the comparison of changes in their turning functions. This study shows that genetic algorithms are suitable for matching polygon features even if these features are quite different. Our results show up to 40% of matched polygons with differences in geometrical attributes. With regards to point matching, the vertex from homologous polygons, the function and threshold values proposed in this paper show a useful method for obtaining precise vertex matching.
Ethanol (E) Impairs Fetal Brain GSH Homeostasis by Inhibiting Excitatory Amino-Acid Carrier 1 (EAAC1)-Mediated Cysteine Transport
Authors: Patel Dhyanesh , Mahimainathan Lenin , Narasimhan Madhusudhanan , Rathinam Marylatha , Henderson George
Published: December 2017

Central among the fetotoxic responses to in utero ethanol (E) exposure is redox-shift related glutathione (GSH) loss and apoptosis. Previously, we reported that despite an E-generated Nrf2 upregulation, fetal neurons still succumb. In this study, we investigate if the compromised GSH results from an impaired inward transport of cysteine (Cys), a precursor of GSH in association with dysregulated excitatory amino acid carrier1 (EAAC1), a cysteine transporter. In utero binge model involves administration of isocaloric dextrose or 20% E (3.5 g/kg)/ by gavage at 12 h intervals to pregnant Sprague Dawley (SD) rats, starting gestation day (gd) 17 with a final dose on gd19, 2 h prior to sacrifice. Primary cerebral cortical neurons (PCNs) from embryonic day 16–17 fetal SD rats were the in vitro model. E reduced both PCN and cerebral cortical GSH and Cys up to 50% and the abridged GSH could be blocked by administration of N-acetylcysteine. E reduced EAAC1 protein expression in utero and in PCNs (p < 0.05). This was accompanied by a 60–70% decrease in neuron surface expression of EAAC1 along with significant reductions of EAAC1/Slc1a1 mRNA (p < 0.05). In PCNs, EAAC1 knockdown significantly decreased GSH but not oxidized glutathione (GSSG) illustrating that while not the sole provider of Cys, EAAC1 plays an important role in neuron GSH homeostasis. These studies strongly support the concept that in both E exposed intact fetal brain and cultured PCNs a mechanism underlying E impairment of GSH homeostasis is reduction of import of external Cys which is mediated by perturbations of EAAC1 expression/function.
Variable Isotopic Compositions of Host Plant Populations Preclude Assessment of Aphid Overwintering Sites
Authors: Crossley Michael , Steffan Shawn , Voegtlin David , Hamilton Krista , Hogg David
Published: December 2017

Soybean aphid (Aphis glycines Matsumura) is a pest of soybean in the northern Midwest whose migratory patterns have been difficult to quantify. Improved knowledge of soybean aphid overwintering sites could facilitate the development of control efforts with exponential impacts on aphid densities on a regional scale. In this preliminary study, we explored the utility of variation in stable isotopes of carbon and nitrogen to distinguish soybean aphid overwintering origins. We compared variation in bulk 13C and 15N content in buckthorn (Rhamnus cathartica L.) and soybean aphids in Wisconsin, among known overwintering locations in the northern Midwest. Specifically, we looked for associations between buckthorn and environmental variables that could aid in identifying overwintering habitats. We detected significant evidence of correlation between the bulk 13C and 15N signals of soybean aphids and buckthorn, despite high variability in stable isotope composition within and among buckthorn plants. Further, the 15N signal in buckthorn varied predictably with soil composition. However, lack of sufficient differentiation of geographic areas along axes of isotopic and environmental variation appears to preclude the use of carbon and nitrogen isotopic signals as effective predictors of likely aphid overwintering sites. These preliminary data suggest the need for future work that can further account for variability in 13C and 15N within/among buckthorn plants, and that explores the utility of other stable isotopes in assessing likely aphid overwintering sites.
Adipose Derived Stem Cells for Corneal Wound Healing after Laser Induced Corneal Lesions in Mice
Authors: Zeppieri Marco , Salvetat Maria Letizia , Beltrami Antonio , Cesselli Daniela , Russo Rossella , Alcalde Ignacio , Merayo-Lloves Jesús , Brusini Paolo , Parodi Pier Camillo
Published: December 2017

The aim of our study was to assess the clinical effectiveness of topical adipose derived stem cell (ADSC) treatment in laser induced corneal wounds in mice by comparing epithelial repair, inflammation, and histological analysis between treatment arms. Corneal lesions were performed on both eyes of 40 mice by laser induced photorefractive keratectomy. All eyes were treated with topical azythromycin bid for three days. Mice were divided in three treatment groups (n = 20), which included: control, stem cells and basic serum; which received topical treatment three times daily for five consecutive days. Biomicroscope assessments and digital imaging were performed by two masked graders at 30, 54, 78, 100, and 172 h to analyze extent of fluorescein positive epithelial defect, corneal inflammation, etc. Immunohistochemical techniques were used in fixed eyes to assess corneal repair markers Ki67, α Smooth Muscle Actin (α-SMA) and E-Cadherin. The fluorescein positive corneal lesion areas were significantly smaller in the stem cells group on days 1 (p < 0.05), 2 (p < 0.02) and 3. The stem cell treated group had slightly better and faster re-epithelization than the serum treated group in the initial phases. Comparative histological data showed signs of earlier and better corneal repair in epithelium and stromal layers in stem cell treated eyes, which showed more epithelial layers and enhanced wound healing performance of Ki67, E-Cadherin, and α-SMA. Our study shows the potential clinical and histological advantages in the topical ADSC treatment for corneal lesions in mice.
Sibilant Merger in the Variety of Basque Spoken in Amorebieta-Etxano
Authors: Muxika-Loitzate Oihane
Published: December 2017

Basque has an apico-alveolar /s̺/, a lamino-alveolar /s̻/, and a prepalatal sibilant /ʃ/ that are represented by the letters
, , and , respectively. The apico-alveolar and the lamino-alveolar sibilants have merged in some areas of Biscay, Guipuzcoa, and the Basque-speaking territories of Alava (e.g., Hualde 2010), and Spanish has been hypothesized as a factor driving this merger (Jurado Noriega 2011). On the other hand, complex sibilant systems like the traditional Basque one tend to be neutralized independently of language contact (Bukmaier et al. 2014). In order to add to this debate and shed new light on the merger, this study explored Biscayan Basque, a variety at an advanced state of the merger (Hualde 2010). More precisely, the study tested how the degree of bilingualism affects the production of the sibilants under study and the resulting neutralization by performing an acoustic analysis of the data. The results show that Basque- and Spanish-dominant speakers behave differently with regard to the sibilant merger, and that they have different places of articulation for their sibilants. Only Basque-dominant speakers maintain a significant distinction in the place of articulation of  and  overall, whereas Spanish-dominant speakers do not make a distinction among sibilants. Furthermore, the resulting merged sibilant is less fronted for Spanish-dominant speakers than the sibilants of Basque-dominant speakers.
Kin Selection in the RNA World
Authors: Levin Samuel , West Stuart
Published: December 2017

Various steps in the RNA world required cooperation. Why did life’s first inhabitants, from polymerases to synthetases, cooperate? We develop kin selection models of the RNA world to answer these questions. We develop a very simple model of RNA cooperation and then elaborate it to model three relevant issues in RNA biology: (1) whether cooperative RNAs receive the benefits of cooperation; (2) the scale of competition in RNA populations; and (3) explicit replicator diffusion and survival. We show: (1) that RNAs are likely to express partial cooperation; (2) that RNAs will need mechanisms for overcoming local competition; and (3) in a specific example of RNA cooperation, persistence after replication and offspring diffusion allow for cooperation to overcome competition. More generally, we show how kin selection can unify previously disparate answers to the question of RNA world cooperation.
Intratubular Biomineralization in a Root Canal Filled with Calcium-Enriched Material over 8 Years
Authors: Yoo Yeon-Jee , Lee Yoo , Yoo Jun , Perinpanayagam Hiran , Yoo Chang , Kang Hyen , Oh Soram , Chang Seok , Kum Kee-Yeon
Published: December 2017

This case report describes intratubular biomineralization in root canal, filled with calcium-enriched material after 8 years of clinical maintenance. The schematic findings of dentinal tubules were investigated with scanning electron microscopy (SEM) and energy dispersive spectroscopy (EDS). The root canal obturation material was closely adapted to root dentin surface, suggesting the possibility of chemical bonding between the two interfaces. SEM and EDS observation of dentinal tubules showed intratubular biomineralized crystal structures with Ca/P ratio in a range of 1.30–2.12, suggesting bioactive capacity of calcium-enriched material.
Understanding Chemistry and Unique NMR Characters of Novel Amide and Ester Leflunomide Analogues
Authors: Henen Morkos , Hamdi Abdelrahman , Farahat Abdelbasset , Massoud Mohammed
Published: December 2017

A series of diverse substituted 5-methyl-isoxazole-4-carboxylic acid amides, imide and esters in which the benzene ring is mono or disubstituted was prepared. Spectroscopic and conformational examination was investigated and a new insight involving steric interference and interesting downfield deviation due to additional diamagnetic anisotropic effect of the amidic carbonyl group and the methine protons in 2,6-diisopropyl-aryl derivative (2) as conformationaly restricted analogues Leflunomide was discussed. Individual substituent electronic effects through π resonance of p-substituents and most stable conformation of compound (2) are discussed.
Indicator Variograms as an Aid for Geological Interpretation and Modeling of Ore Deposits
Authors: Maleki Mohammad , Emery Xavier , Mery Nadia
Published: December 2017

Geostatistics offers a set of methods for modeling, predicting, or simulating geological domains in space. In addition of being an input of some of these methods, indicator direct and cross-variograms convey valuable information on the geometry of the domain layouts and on their contact relationships, in particular, on the surface area of a domain boundary, on the surface area of the contact between two domains, on the propensity for a domain to be in contact with, or separated from, another domain, and on the minimum and maximum distances between points from two domains. Accordingly, the indicator variograms inferred from sparse sampling data can be used to determine whether or not an interpreted model of the subsurface is consistent with the sampling information. The previous concepts are illustrated through a case study corresponding to a porphyry copper deposit.
Lipoprotein Lipase Expression in Chronic Lymphocytic Leukemia: New Insights into Leukemic Progression
Authors: Prieto Daniel , Oppezzo Pablo
Published: December 2017

Lipoprotein lipase (LPL) is a central enzyme in lipid metabolism. Due to its catalytic activity, LPL is involved in metabolic pathways exploited by various solid and hematologic malignancies to provide an extra energy source to the tumor cell. We and others described a link between the expression of LPL in the tumor cell and a poor clinical outcome of patients suffering Chronic Lymphocytic Leukemia (CLL). This leukemia is characterized by a slow accumulation of mainly quiescent clonal CD5 positive B cells that infiltrates secondary lymphoid organs, bone marrow and peripheral blood. Despite LPL being found to be a reliable molecular marker for CLL prognosis, its functional role and the molecular mechanisms regulating its expression are still matter of debate. Herein we address some of these questions reviewing the current state of the art of LPL research in CLL and providing some insights into where currently unexplored questions may lead to.
(−)-Epigallocatechin-3-Gallate Inhibits the Chaperone Activity of Plasmodium falciparum Hsp70 Chaperones and Abrogates Their Association with Functional Partners
Authors: Zininga Tawanda , Ramatsui Lebogang , Makhado Pertunia , Makumire Stanley , Achilinou Ikechukwu , Hoppe Heinrich , Dirr Heini , Shonhai Addmore
Published: December 2017

Heat shock proteins (Hsps), amongst them, Hsp70 and Hsp90 families, serve mainly as facilitators of protein folding (molecular chaperones) of the cell. The Hsp70 family of proteins represents one of the most important molecular chaperones in the cell. Plasmodium falciparum, the main agent of malaria, expresses six Hsp70 isoforms. Two (PfHsp70-1 and PfHsp70-z) of these localize to the parasite cytosol. PHsp70-1 is known to occur in a functional complex with another chaperone, PfHsp90 via a co-chaperone, P. falciparum Hsp70-Hsp90 organising protein (PfHop). (−)-Epigallocatechin-3-gallate (EGCG) is a green tea constituent that is thought to possess antiplasmodial activity. However, the mechanism by which EGCG exhibits antiplasmodial activity is not fully understood. A previous study proposed that EGCG binds to the N-terminal ATPase domain of Hsp70. In the current study, we overexpressed and purified recombinant forms of two P. falciparum cytosol localized Hsp70s (PfHsp70-1 and PfHsp70-z), and PfHop, a co-chaperone of PfHsp70-1. Using the surface plasmon resonance approach, we demonstrated that EGCG directly binds to the two Hsp70s. We further observed that binding of EGCG to the two proteins resulted in secondary and tertiary conformational changes. In addition, EGCG inhibited the ATPase and chaperone function of the two proteins. Furthermore, EGCG abrogated association of the two Hsp70s with their functional partners. Using parasites cultured in vitro at the blood stages, we observed that 2.9 µM EGCG suppressed 50% P. falciparum parasite growth (IC50). Our findings demonstrate that EGCG directly binds to PfHsp70-1 and PfHsp70-z to inhibit both the ATPase and chaperone functions of the proteins. Our study constitutes the first direct evidence suggesting that the antiplasmodial activity of EGCG is at least in part accounted for by its inhibition of Hsp70 function.
Dietary Consumption of Phenolic Acids and Prostate Cancer: A Case-Control Study in Sicily, Southern Italy
Authors: Russo Giorgio , Campisi Daniele , Di Mauro Marina , Regis Federica , Reale Giulio , Marranzano Marina , Ragusa Rosalia , Solinas Tatiana , Madonia Massimo , Cimino Sebastiano , Morgia Giuseppe
Published: December 2017

Dietary polyphenols gained the interest of the scientific community due to their wide content in a variety of plant-derived foods and beverages commonly consumed, such as fruits, vegetables, coffee, tea, and cocoa. We aimed to investigate whether there was an association between dietary phenolic acid consumption and prostate cancer (PCa) in South Italy. We conducted a population-based case-control study from January 2015 to December 2016 in a single institution of the municipality of Catania, southern Italy (Registration number: 41/2015). Patients with elevated PSA and/or suspicious PCa underwent transperineal prostate biopsy. A total of 118 histopathological-verified PCa cases were collected and a total of 222 controls were selected from a sample of 2044 individuals. Dietary data were collected by using two food frequency questionnaires and data on the phenolic acids content in foods was obtained from the Phenol-Explorer database (www.phenol-explorer.eu). Association between dietary intake of phenolic acids and PCa was calculated through logistic regression analysis. We found lower levels of caffeic acid (2.28 mg/day vs. 2.76 mg/day; p < 0.05) and ferulic acid (2.80 mg/day vs. 4.04 mg/day; p < 0.01) in PCa when compared to controls. The multivariate logistic regression showed that both caffeic acid (OR = 0.32; p < 0.05) and ferulic acid (OR = 0.30; p < 0.05) were associated with reduced risk of PCa. Higher intake of hydroxybenzoic acids and caffeic acids were associated with lower risk of advanced PCa. High intake of caffeic acid and ferulic acid may be associated with reduced risk of PCa.
Higher-Order Interactions in Quantum Optomechanics: Analytical Solution of Nonlinearity
Authors: Khorasani Sina
Published: December 2017

A method is described to solve the nonlinear Langevin equations arising from quadratic interactions in quantum mechanics. While the zeroth order linearization approximation to the operators is normally used, here, first and second order truncation perturbation schemes are proposed. These schemes employ higher-order system operators, and then approximate number operators with their corresponding mean boson numbers only where needed. Spectral densities of higher-order operators are derived, and an expression for the second-order correlation function at zero time-delay has been found, which reveals that the cavity photon occupation of an ideal laser at threshold reaches 6 − 2 , in good agreement with extensive numerical calculations. As further applications, analysis of the quantum anharmonic oscillator, calculation of Q-functions, analysis of quantum limited amplifiers, and nondemoliton measurements are provided.
Ethnobotanical Survey, Preliminary Physico-Chemical and Phytochemical Screening of Salvia argentea (L.) Used by Herbalists of the Saïda Province in Algeria
Authors: Benabdesslem Yasmina , Hachem Kadda , Kahloula Khaled , Slimani Miloud
Published: December 2017

An ethnobotanical study was carried out in the Saïda region among herbalists to evaluate the use of Salvia argentea (L.), a plant species native from North Africa belonging to the Lamiaceae family. Forty-two herbalists were interviewed individually, aged between 30 and 70 years, all males, 52.38% of them having received a secondary education level and having performing their duties for more than a decade. This study showed that Salvia argentea is used specifically in the treatment of diseases of the respiratory system. The leaves are the most commonly used part, usually in the form of powder and exclusively administered orally. The preliminary results of the physicochemical characterization and the phytochemical screening of the powdered leaves of Salvia argentea attest to their safety and confer them a guarantee of phytotherapeutic quality.
Effects of Particle Size on the Morphology and Water- and Thermo-Resistance of Washed Cottonseed Meal-Based Wood Adhesives
Authors: He Zhongqi , Cheng Huai , Klasson K. , Olanya O. , Uknalis Joseph
Published: December 2017

Water washing of cottonseed meal is more cost-efficient and environmentally friendly than protein isolation by means of alkaline extraction and acidic precipitation. Thus, water-washed cottonseed meal (WCSM) is more promising as biobased wood adhesives. In this work, we examined the effects of the particle size on the morphology and adhesive performance of WCSM. Pilot-scale produced and dried WCSM was treated by three grinding methods: (1) ground by a hammer mill and passed through a 0.5-mm screen, (2) further ground by a cyclone mill and passed through a 0.5-mm screen, or (3) further ground by a ball mill and passed through a 0.18-mm screen. Micro-morphological examination revealed two types of particles. The filament-like particles were mainly fibrous materials from residual linters. Chunk-like particles were more like aggregates or accumulations of small particles, with proteins as the major component. Further grinding of the 0.5-mm Hammer product with the Cyclone and Ball mill led to more fine (smaller) particles in the WCSM products. The impact of further grinding on the dry and soaked adhesive strengths was minimal. However, the decrease of the hot and wet strengths of WCSM products by the additional grinding was significant (p ≤ 0.05). Data presented in this work is useful in developing the industrial standards of WCSM products used in wood bonding.
Ocean Wind and Wave Measurements Using X-Band Marine Radar: A Comprehensive Review
Authors: Huang Weimin , Liu Xinlong , Gill Eric
Published: December 2017

Ocean wind and wave parameters can be measured by in-situ sensors such as anemometers and buoys. Since the 1980s, X-band marine radar has evolved as one of the remote sensing instruments for such purposes since its sea surface images contain considerable wind and wave information. The maturity and accuracy of X-band marine radar wind and wave measurements have already enabled relevant commercial products to be used in real-world applications. The goal of this paper is to provide a comprehensive review of the state of the art algorithms for ocean wind and wave information extraction from X-band marine radar data. Wind measurements are mainly based on the dependence of radar image intensities on wind direction and speed. Wave parameters can be obtained from radar-derived wave spectra or radar image textures for non-coherent radar and from surface radial velocity for coherent radar. In this review, the principles of the methodologies are described, the performances are compared, and the pros and cons are discussed. Specifically, recent developments for wind and wave measurements are highlighted. These include the mitigation of rain effects on wind measurements and wave height estimation without external calibrations. Finally, remaining challenges and future trends are discussed.
The Relationship between Trail Running Withdrawals and Race Topography
Authors: Roberta Antonini , Nadège Rochat , Fabienne Crettaz , Denis Hauw
Published: December 2017

Context: A growing amount of recent research in sport psychology has focused on trying to understand withdrawals from ultra-races. However, according to the Four E approach, the studies underestimated the embedded components of these experiences and particularly how they were linked to the specific environmental conditions in which the experiences occurred. Objective: This study aimed to characterize trail running withdrawals in relationship to race topography. Design: Qualitative design, involving self-confrontation interviews and use of a race map. Setting: Use of the race map for description of the race activity and self-confrontation interviews took place 1–3 days after the races. Participants: Ten runners who withdrew during an ultra-trail race. Data Collection and Analysis: Data on past activity traces and experiences were elicited from self-confrontation interviews. Data were coded and compared to identify common sequences and then each type of sequence was counted with regard to race topography. Results: Results showed that each sequence was related to runners’ particular possibilities for acting, feeling, and thinking, which were in turn embedded in the race topography. These sequences allowed the unfolding of the activity and increased its overall effectiveness in relation to the constraints of this specific sport. Conclusion: This study allowed us to highlight important information on how ultra-trail runners manage their races in relationship to the race environment and more specifically to its topography. The result will also help us to recommend potential adjustments to ultra-trail runners’ performance-oriented training and preparation.
City Brand Personality—Relations with Dimensions and Dimensions Inter-Relations
Authors: Țugulea Oana
Published: December 2017

City brand strategies play an important part in building strong identities for cities and also for effective promotional campaigns. The purpose of this research is to analyze in more depth the dimensions of the City Brand Personality of Iași, as identified in previous research. The objectives of the present study are to: (1) understand the impact of each dimension upon the entire construct; (2) identify the possible connections between the perception of the city brand personality and the perceptions on particular city features; (3) identify the possible inter-connections between the resulting dimensions. An Independent Samples t test, Discriminant analysis, and Correlations and Regressions analysis were conducted. The dimension Peacefulness/Sincerity has the highest positive impact, while the dimension Malignacy has the lowest negative impact. Respondents who consider the city to be relatively young rate the personality features better for the dimensions of Peacefulness/Sincerity and Competence. Competence and Peacefulness/Sincerity are strongly related. Improving the perception of features composing the Competence dimension leads to an improvement of the entire City Brand Personality. Future research could specifically identify the types of sustainable activities that could be associated with the desired personality traits.
Energy Toolbox—Framework for the Development of a Tool for the Primary Design of Zero Emission Buildings in European and Asian Cities
Authors: Koller Christoph , Talmon-Gros Max , Junge Ranka , Schuetze Thorsten
Published: December 2017

This paper discusses the framework for the development of an Energy Toolbox (ETB). The aim of the ETB is to support the design of domestic Zero Emission Buildings (ZEBs), according to the concept of net zero-energy buildings during the early architectural design and planning phases. The ETB concept is based on the calculation of the energy demand for heating, cooling, lighting, and appliances. Based on a building’s energy demand, technologies for the onsite conversion and production of the specific forms and quantities of final and primary energy by means of renewable energy carriers can be identified. The calculations of the ETB are based on the building envelope properties of a primary building design, as well as the physical and climate parameters required for the calculation of heat transfer coefficients, heat gains, and heat losses. The ETB enables the selection and rough dimensioning of technologies and systems to meet, and, wherever possible, reduce the thermal and electric energy demand of a building. The technologies included comprise green facades, adaptable dynamic lighting, shading devices, heat pumps, photovoltaic generators, solar thermal collectors, adiabatic cooling, and thermal storage. The ETB facilitates the balancing of the energy consumption and the production of renewable energies of a primary building design.
Transformation Planning of Ecotourism Systems to Invigorate Responsible Tourism
Authors: Choi Yun , Doh Minsun , Park Samuel , Chon Jinhyung
Published: December 2017

The purpose of this study is to introduce transformation plans that can stimulate responsible ecotourism by using systems thinking to solve ecotourism problems in Korea. Systems thinking is a research method used to understand the operating mechanisms of the variables that influence an entire system, in order to identify its problems. The four types of ecotourism systems are classified as follows: low-infrastructure and resident-initiated, high-infrastructure and resident-initiated, high-infrastructure and government-initiated and low-infrastructure and government-initiated. These systems vary based on the need for tourism facilities and the form of governance. Each type of system is analyzed using the systems thinking process (dynamic thinking, causal thinking, feedback thinking, strategic thinking) at representative ecotourism sites in Jeollanam-do and the following transformation plans are proposed to improve the responsibility at the tourism sites: First, local residents will develop a system to manage and operate ecotourism ventures and establish cooperative governance structures to strengthen the local capacity. Second, ecotourism operators will improve the quality of their educational and interpretative programs and tourist information platforms in order to raise awareness of the responsibilities of ecotourists. Third, ecotourism systems that are improved through ecotourists’ and tour operators' heightened senses of responsibility can sustain ecotourism independently. These transformation plans can be applied to policy proposals for revitalizing ecotourism, to guidelines for improving community resilience and to biological habitat protection plans. This study is meaningful in that it discusses the role of stakeholders in ecotourism planning and promoting responsible tourism and their role in utilizing and conserving natural resources accordingly.
Genomic Characterisation of Vinegar Hill Virus, An Australian Nairovirus Isolated in 1983 from Argas Robertsi Ticks Collected from Cattle Egrets
Authors: Gauci Penelope , McAllister Jane , Mitchell Ian , Cybinski Daisy , St George Toby , Gubala Aneta
Published: December 2017

This report describes the near complete genomic sequence and subsequent analysis of Vinegar Hill virus (VINHV; tentative member of the genus Orthonairovirus, family Nairoviridae, order Bunyavirales). VINHV is the second nairovirus reported to be isolated on mainland Australia and the first to be sequenced and analysed. Our genetic analysis shows that VINHV belongs to the Dera Ghazi Khan genogroup, a group of viruses previously isolated in other parts of the world including Asia, South Africa, and the USA. We discuss possible routes of entry for nairoviruses into Australia and the need to understand the virome of Australian ticks in the context of new and emerging disease.
A Statistical Method to Predict Flow Permanence in Dryland Streams from Time Series of Stream Temperature
Authors: Arismendi Ivan , Dunham Jason , Heck Michael , Schultz Luke , Hockman-Wert David
Published: December 2017

Intermittent and ephemeral streams represent more than half of the length of the global river network. Dryland freshwater ecosystems are especially vulnerable to changes in human-related water uses as well as shifts in terrestrial climates. Yet, the description and quantification of patterns of flow permanence in these systems is challenging mostly due to difficulties in instrumentation. Here, we took advantage of existing stream temperature datasets in dryland streams in the northwest Great Basin desert, USA, to extract critical information on climate-sensitive patterns of flow permanence. We used a signal detection technique, Hidden Markov Models (HMMs), to extract information from daily time series of stream temperature to diagnose patterns of stream drying. Specifically, we applied HMMs to time series of daily standard deviation (SD) of stream temperature (i.e., dry stream channels typically display highly variable daily temperature records compared to wet stream channels) between April and August (2015–2016). We used information from paired stream and air temperature data loggers as well as co-located stream temperature data loggers with electrical resistors as confirmatory sources of the timing of stream drying. We expanded our approach to an entire stream network to illustrate the utility of the method to detect patterns of flow permanence over a broader spatial extent. We successfully identified and separated signals characteristic of wet and dry stream conditions and their shifts over time. Most of our study sites within the entire stream network exhibited a single state over the entire season (80%), but a portion of them showed one or more shifts among states (17%). We provide recommendations to use this approach based on a series of simple steps. Our findings illustrate a successful method that can be used to rigorously quantify flow permanence regimes in streams using existing records of stream temperature.
Developing a written action plan for children with eczema: a qualitative study
Authors: Powell Kingsley , Le Roux Emma , Banks Jonathan P , Ridd Matthew J
Published: December 2017

Background

Eczema is common in children but adherence to treatments is poor. Written action plans (WAPs) have been shown to help in asthma but the potential value, format, and content of an eczema WAP is unknown.

Aim

To explore the potential role of an eczema WAP, and to design an eczema-specific WAP.

Design and setting

A qualitative study of parents of children with eczema, primary and secondary care health professionals, and other stakeholders.

Method

A total of 41 semi-structured one-to-one interviews and two focus groups were audiorecorded, transcribed, and analysed thematically.

Results

Reported challenges of managing eczema included: parental confusion about treatment application; lack of verbal and written advice from GPs; differing beliefs about the cause and management of eczema; re-prescribing of failed treatments; and parents feeling unsupported by their GP. An eczema WAP was viewed as an educational tool that could help address these problems. Participants expressed a preference for a WAP that gives clear, individualised guidance on treatment use, presented in a step-up/step-down approach. Participants also wanted more general information about eczema, its potential triggers, and how to manage problem symptoms.

Conclusion

An eczema WAP may help overcome some of the difficulties of managing eczema, and support families and clinicians in the management of the condition. Further evaluation is needed to determine if the eczema WAP the authors have developed is both acceptable and improves the outcomes for affected children and their families.
Patients’ views on interactions with practitioners for type 2 diabetes: a longitudinal qualitative study in primary care over 10 years
Authors: Dambha-Miller Hajira , Silarova Barbora , Irving Greg , Kinmonth Ann Louise , Griffin Simon J
Published: December 2017

Background

It has been suggested that interactions between patients and practitioners in primary care have the potential to delay progression of complications in type 2 diabetes. However, as primary care faces greater pressures, patient experiences of patient–practitioner interactions might be changing.

Aim

To explore the views of patients with type 2 diabetes on factors that are of significance to them in patient–practitioner interactions in primary care after diagnosis, and over the last 10 years of living with the disease.

Design and setting

A longitudinal qualitative analysis over 10 years in UK primary care.

Method

The study was part of a qualitative and quantitative examination of patient experience within the existing ADDITION-Cambridge and ADDITION-Plus trials from 2002 to 2016. The researchers conducted a qualitative descriptive analysis of free-text comments to an open-ended question within the CARE measure questionnaire at 1 and 10 years after diagnosis with diabetes. Data were analysed cross-sectionally at each time point, and at an individual level moving both backwards and forwards between time points to describe emergent topics.

Results

At the 1-year follow-up, 311 out of 1106 (28%) participants had commented; 101 out of 380 (27%) participants commented at 10-year follow-up; and 46 participants commented at both times. Comments on preferences for face-to-face contact, more time with practitioners, and relational continuity of care were more common over time.

Conclusion

This study highlights issues related to the wider context of interactions between patients and practitioners in the healthcare system over the last 10 years since diagnosis. Paradoxically, these same aspects of care that are valued over time from diagnosis are also increasingly unprotected in UK primary care.
Reasons why people do not attend NHS Health Checks: a systematic review and qualitative synthesis
Authors: Harte Emma , MacLure Calum , Martin Adam , Saunders Catherine L , Meads Catherine , Walter Fiona M , Griffin Simon J , Mant Jonathan , Usher-Smith Juliet A
Published: December 2017

Background

The NHS Health Check programme is a prevention initiative offering cardiovascular risk assessment and management advice to adults aged 40–74 years across England. Its effectiveness depends on uptake. When it was introduced in 2009, it was anticipated that all those eligible would be invited over a 5-year cycle and 75% of those invited would attend. So far in the current cycle from 2013 to 2018, 33.8% of those eligible have attended, which is equal to 48.5% of those invited to attend. Understanding the reasons why some people do not attend is important to maximise the impact of the programmes.

Aim

To review why people do not attend NHS Health Checks.

Design and setting

A systematic review and thematic synthesis of qualitative studies.

Method

An electronic literature search was carried out of MEDLINE, Embase, Health Management Information Consortium, Cumulative Index to Nursing and Allied Health Literature, Global Health, PsycINFO, Web of Science, OpenGrey, the Cochrane Library, NHS Evidence, Google Scholar, Google, ClinicalTrials.gov, and the ISRCTN registry from 1 January 1996 to 9 November 2016, and the reference lists of all included papers were also screened manually. Inclusion criteria were primary research studies that reported the views of people who were eligible for but had not attended an NHS Health Check.

Results

Nine studies met the inclusion criteria. Reasons for not attending included lack of awareness or knowledge, misunderstanding the purpose of the NHS Health Check, aversion to preventive medicine, time constraints, difficulties with access to general practices, and doubts regarding pharmacies as appropriate settings.

Conclusion

The findings particularly highlight the need for improved communication and publicity around the purpose of the NHS Health Check programme and the personal health benefits of risk factor detection.
Travel Career Patterns: The Motivations of Indonesian and Malaysian Muslim Tourists
Authors: Oktadiana Hera , Pearce Philip L. , Pusiran Arif Kamisan , Agarwal Manisha
Published: December 2017

Indonesia and Malaysia have a combined population of ~225 million Muslims. Little academic work has been conducted on their motives for nonpilgrimage, leisure-based travel. Building on the travel career pattern approach for assessing tourist motivation, the this study sought to uncover
the motivational patterns of Muslim tourists in this part of Southeast Asia. A combined total of 356 respondents from the two countries were sampled and the patterns of tourist motives between these Muslim tourists and data from previous studies of Western tourists were compared. Comparisons
between the Malaysian data and the Indonesian data were also undertaken. The special importance of relationships, nature appreciation, and safety in the Muslim data compared to responses from Western respondents was identified. Close parallels between the Malaysian and Indonesian Muslim motivation
patterns were found. The results were interpreted as highly consistent with Islamic teaching and the collectivist culture of the two communities.
Tourists' Attitudes Toward Religious Commercialization
Authors: Huang Keji , Pearce Philip , Wen Junjie
Published: December 2017

Commercial activities exist at different religious sites and the practices arouse global concern. This study identifies and assesses religious commercial activities and explores how they affect tourists' attitudes. The well-known Four Great Buddhist Mountains in China were selected
as research sites. Using grounded theory, this study initially conducted 80 detailed interviews to build an understanding of commercialization and then investigated 438 travel blogs. The resulting seven commercial categories were: entrance ticket, food and drinks, accommodation, transportation,
shopping, staff service, and entertainment. In addition, the level of different commercial categories for all research sites were assessed. The findings showed that tourists had more negative comments about food and drinks, accommodation, and staff service, with less criticism of transportation
and entertainment. It implied that tourists were more likely to feel annoyed when tourism products have ambiguous or exaggerated prices and there is a lack of uniform service standards. The research findings offer insights for sustainable development of religious tourism aiming to benefit
both local communities and tourists.
The Role of Tour Operators and Suppliers in the Resident–Visitor Relationship: Chinese Mass Tourism in East Malaysia
Authors: Peters Robert Francis
Published: December 2017

In tourism, local residents and foreign visitors do sometimes patronize the same hosts (e.g., service providers). Conflict between a resident and a visitor is organic and unavoidable at any tourism destination. Although there is a huge literature about this conflict, the process that
is involved in the development or resolution of the conflict has not been described adequately. Documenting the process could provide an understanding of the role and importance of hospitality to a relationship between two different groups of people. To document the resident–visitor
relationship, a case study on the development of mass tourism at Kota Kinabalu was carried out through a combination of communication media investigative methods to uncover social processes associated with hospitality. The findings showed that new or amateur tourism operators began supporting
mass tourism by misappropriating local culture and traditions in the beginning of mass tourism. This misappropriation affected hospitality, leading to a resource competition between a resident and a visitor. This competition eventually evolved into a conflict. Furthermore, the findings showed
that tourism suppliers are tasked to address and resolve the conflict between the residents and the visitors, and they do this by introducing a different form of hospitality. As a result, the resident–visitor relationship is changed. Hence, hospitality is a decisive relationship factor
and its absence qualifies tourism being for the masses.