bluuebunny/crossref_metadata_2025 huggingface dataset:
Definition of Personalized Medicine and Targeted Therapies: Does Medical Familiarity Matter?
Authors: Fournier Valentyn , Prebet Thomas , Dormal Alexandra , Brunel Maïté , Cremer Robin , Schiaratura Loris
Published: January 2021

Personalized medicine (PM) is increasingly becoming a topic of discussion in public health policies and media. However, there is no consensus among definitions of PM in the scientific literature and the terms used to designate it, with some definitions emphasizing patient-centered aspects and others emphasizing biomedical aspects. Furthermore, terms used to refer to PM (e.g., “pharmacogenomics” or, more often, “targeted therapies”) are diverse and differently used. To our knowledge, no study has apprehended the differences of definition and attitudes toward personalized medicine and targeted therapies according to level of familiarity with the medical field. Our cohort included 349 French students from three different academic fields, which modulated their familiarity level with the medical field. They were asked to associate words either to “personalized medicine” or “target therapies”. Then, they were asked to give an emotional valence to their associations. Results showed that nonfamiliar students perceived PM as more positive than targeted therapies (TT), whereas familiar students showed no difference. Only familiar students defined PM and TT with technical aspects such as genetics or immunology. Further studies are needed in the field in order to determine which other factors could influence the definitions of PM and TT and determine how these definitions could have an impact in a clinical setting.
At the Crossroads of European Landscape Changes: Major Processes of Landscape Change in Czechia since the Middle of the 19th Century and Their Driving Forces
Authors: Kupková Lucie , Bičík Ivan , Jeleček Leoš
Published: January 2021

Changes in the cultural landscape provide essential evidence about the manner and intensity of the interactions between humans and nature. Czechia has a specific location in Central Europe. It is positioned at the crossroads of European landscape changes. These changes can be documented based on a unique database that shows the development of land use since the middle of the 19th century. In this study, we aimed to address the major processes of landscape change that occurred during four periods over the past 165 years, at the cadastral level on the territory of present-day Czechia. Further we identify and discuss proximate and underlying driving forces of the landscape changes. We used land use data from the year 1845, 1896, 1948, 1990, and 2010 that correspond to key events in Czech history. The major processes and intensity of landscape change were evaluated based on calculations of increases and decreases in land use classes between the first and last year of each examined period. The period 1845–1896 was the only period in which arable land increased, and the most recent period, 1990–2010, was the only period during which a grassing over process was recorded. Afforestation was recorded in all periods. The communist period was characterized by unified changes—urbanization, afforestation, arable land decrease, and landscape devastation. The post-communist period was, in some respects, beneficial to the landscape (e.g., grassing over and afforestation, particularly in mountain areas), but it also led to negative processes, such as strong urbanization and land abandonment. Such changes lead to landscape polarization. The landscape changes in Czechia during the period 1845–2010 reflect many important historical events in Europe. In our analysis, we demonstrate the essential impact of underlying drivers and also identify driving forces specific to the development of the Czech territory.
A Systematic Two-Sample Mendelian Randomization Analysis Identifies Shared Genetic Origin of Endometriosis and Associated Phenotypes
Authors: Garitazelaia Aiara , Rueda-Martínez Aintzane , Arauzo Rebeca , de Miguel Jokin , Cilleros-Portet Ariadna , Marí Sergi , Bilbao Jose Ramon , Fernandez-Jimenez Nora , García-Santisteban Iraia
Published: January 2021

Endometriosis, one of the most common gynecological disorders, is a complex disease characterized by the growth of endometrial-like tissue in extra-uterine locations and is a cause of pelvic pain and infertility. Evidence from observational studies indicate that endometriosis usually appears together with several other phenotypes. These include a list of autoimmune diseases, most of them more prevalent in women, anthropometric traits associated with leanness in the adulthood, as well as female reproductive traits, including altered hormone levels and those associated with a prolonged exposure to menstruation. However, the biological mechanisms underlying their co-morbidity remains unknown. To explore whether those phenotypes and endometriosis share a common genetic origin, we performed a systematic Two-Sample Mendelian Randomization (2SMR) analysis using public GWAS data. Our results suggest potential common genetic roots between endometriosis and female anthropometric and reproductive traits. Particularly, our data suggests that reduced weight and BMI might be mediating the genetic susceptibility to suffer endometriosis. Furthermore, data on female reproductive traits strongly suggest that genetic variants that predispose to a more frequent exposure to menstruation, through earlier age at menarche and shorter menstrual cycles, might also increase the risk to suffer from endometriosis.
On the Direct Limit from Pseudo Jacobi Polynomials to Hermite Polynomials
Authors: Jafarov Elchin I. , Mammadova Aygun M. , Van der Jeugt Joris
Published: January 2021

In this short communication, we present a new limit relation that reduces pseudo-Jacobi polynomials directly to Hermite polynomials. The proof of this limit relation is based upon 2F1-type hypergeometric transformation formulas, which are applicable to even and odd polynomials separately. This limit opens the way to studying new exactly solvable harmonic oscillator models in quantum mechanics in terms of pseudo-Jacobi polynomials.
Fixed Point Theory Using ψ Contractive Mapping in

C
∗

-Algebra Valued B-Metric Space
Authors: Mustafa Rahmah , Omran Saleh , Nguyen Quang Ngoc
Published: January 2021

In this paper, fixed point theorems using ψ contractive mapping in C∗-algebra valued b-metric space are introduced. By stating multiple scenarios that illustrate the application domains, we demonstrate several applications from the obtained results. In particular, we begin with the definition of the positive function and then recall some properties of the function that lay the fundamental basis for the research. We then study some fixed point theorems in the C∗-algebra valued b-metric space using a positive function.
Evaluation of Chromosomal Structural Anomalies in Fertility Disorders
Authors: Serapinas Danielius , Valantinavičienė Emilija , Machtejevienė Eglė , Bartkevičiūtė Agnė , Bartkevičienė Daiva
Published: January 2021

Background and objectives: Reproductive disorders may occur not only due to environmental factors (air pollution, stressful lifestyle, previous abortions or the use of contraceptives) but also due to genetic factors. Materials and Methods: The aim of the study was to identify the range and frequency of chromosomal aberrations in couples (n = 99) with infertility or recurrent miscarriages in Lithuania. The data were collected from the out-patient medical histories. The couples were divided into three groups based on pregnancy, childbirth and the number of miscarriages. The Chi-square test was used to carry out the statistical analysis, and the statistical significance was (p < 0.05). Results: There were 6.6% (n = 13) structural changes observed in the karyotype tests. Chromosomal aberrations were found in 3% (n = 6) of the subjects, while 3.6% (n = 7) of them had chromosomal length polymorphisms. No difference was found between the aberration frequency in the karyotypes of men and women (p > 0.05). The most common aberrations were balanced translocations (23.1%, n = 3) which accounted for 15.4% of the reciprocal (n = 2) and 7.7% of the Robertsonian type (n = 1) of translocations. The most frequent aberrations were found in couples with the inability to conceive (42.9% (n = 3), p = 0.031). The childless couples and those with recurrent miscarriages showed an aberration rate of 8.2% (n = 5), while in the couples with at least one child it was 16.1% (n = 5). The group of couples unable to conceive had a significantly higher aberration rate of 28.6% (n = 2), p = 0.029. Miscarriages in partners’ families accounted for 8.1%. Miscarriages on the female side of the family accounted for 4.5% (n = 9), on the male side it accounted for 2.5% (n = 5) and on both sides it accounted for 1.1% (n = 2). There were no statistically significant differences observed between the female and male sides (p > 0.05). The miscarriages observed in the second group of couples (childless with ≥2 miscarriages) were more frequent at 18.1% (n = 11), in the third group (having children ≥2 miscarriages) they were less frequent at 12.9% (n = 4), while no miscarriages were recorded in the first group of infertile couples. In total, 3% of the identified significant chromosomal aberrations were likely to trigger miscarriages or the inability to conceive. Conclusions: In couples with reproductive disorders, chromosomal mutations and chromosomal length polymorphisms were found at similar rates: 3% vs. 3.6%. The highest aberration rate was found in couples that were unable to conceive, a lower one was found in a group with children and ≥2 miscarriages, and the lowest one was found in a childless group of subjects with ≥2 miscarriages. The miscarriage rate in partner families was 8.1%; however, no difference was found between the male and female sides.
Superficial Effects of Ball Burnishing on TRIP Steel AISI 301LN Sheets
Authors: Jerez-Mesa Ramón , Fargas Gemma , Roa Joan Josep , Llumà Jordi , Travieso-Rodriguez J. Antonio
Published: January 2021

This paper explores the consequences of applying an ultrasonic vibration-assisted ball burnishing process and its non-vibration assisted version on the topology and subsurface microstructure of a transformation-induced plasticity AISI 301LN alloy. More specifically, four different metallographic conditions provided as 1.5-mm thickness sheets and characterized by different starting martensite content (3, 10, 20 and 40 wt.%) are included in the study. Ball burnishing was performed along the lamination direction and perpendicular to it. Results show that the effect of ball burnishing is strongly correlated with the pre-existing microstructure. The steel containing the lowest quantity of initial martensite is the most affected by the process, achieving a higher residual hardening effect, similar to the untreated steel with an original martensitic content of around 40 wt.%. Moreover, the process succeeds in generating a 100-nm thick nanograin layer under the plate subsurface. Finally, no conspicuous effect of the application of vibration assistance was observed, which encourages the application of alternative measurement techniques in future works to define its effect on the properties after being ball burnished.
Study on the Phase Selection and Debye Temperature of Hyper-Peritectic Al-Ni Alloy under High Pressure
Authors: Wang Xiaohong , Chen Zhipeng , Dong Duo , Zhu Dongdong , Wang Hongwei , Wei Zunjie
Published: January 2021

The phase selection of hyper-peritectic Al-47wt.%Ni alloy solidified under different pressures was investigated. The results show that Al3Ni2 and Al3Ni phases coexist at ambient pressure, while another new phase α-Al exists simultaneously when solidified at high pressure. Based on the competitive growth theory of dendrite, a kinetic stabilization of metastable peritectic phases with respect to stable ones is predicted for different solidification pressures. It demonstrates that Al3Ni2 phase nucleates and grows directly from the undercooled liquid. Meanwhile, the Debye temperatures of Al-47wt.%Ni alloy that fabricated at different pressures were also calculated using the low temperature heat capacity curve.
7β-(3-Ethyl-cis-crotonoyloxy)-1α-(2-methylbutyryloxy)-3,14-dehydro-Z Notonipetranone Attenuates Neuropathic Pain by Suppressing Oxidative Stress, Inflammatory and Pro-Apoptotic Protein Expressions
Authors: Khan Amna , Khan Adnan , Khalid Sidra , Shal Bushra , Kang Eunwoo , Lee Hwaryeong , Laumet Geoffroy , Seo Eun Kyoung , Khan Salman
Published: January 2021

7β-(3-Ethyl-cis-crotonoyloxy)-1α-(2-methylbutyryloxy)-3,14-dehydro-Z-notonipetranone (ECN), a sesquiterpenoid obtained from a natural source has proved to be effective in minimizing various side effects associated with opioids and nonsteroidal anti-inflammatory drugs. The current study focused on investigating the effects of ECN on neuropathic pain induced by partial sciatic nerve ligation (PSNL) by mainly focusing on oxidative stress, inflammatory and apoptotic proteins expression in mice. ECN (1 and 10 mg/kg, i.p.), was administered once daily for 11 days, starting from the third day after surgery. ECN post-treatment was found to reduce hyperalgesia and allodynia in a dose-dependent manner. ECN remarkably reversed the histopathological abnormalities associated with oxidative stress, apoptosis and inflammation. Furthermore, ECN prevented the suppression of antioxidants (glutathione, glutathione-S-transferase, catalase, superoxide dismutase, NF-E2-related factor-2 (Nrf2), hemeoxygenase-1 and NAD(P)H: quinone oxidoreductase) by PSNL. Moreover, pro-inflammatory cytokines (tumor necrotic factor-alpha, interleukin 1 beta, interleukin 6, cyclooxygenase-2 and inducible nitric oxide synthase) expression was reduced by ECN administration. Treatment with ECN was successful in reducing the caspase-3 level consistent with the observed modulation of pro-apoptotic proteins. Additionally, ECN showed a protective effect on the lipid content of myelin sheath as evident from FTIR spectroscopy which showed the shift of lipid component bands to higher values. Thus, the anti-neuropathic potential of ECN might be due to the inhibition of oxidative stress, inflammatory mediators and pro-apoptotic proteins.
Macrophage Migration Inhibitory Factor (MIF) and Its Homologue D-Dopachrome Tautomerase (DDT) Inversely Correlate with Inflammation in Discoid Lupus Erythematosus
Authors: Caltabiano Rosario , De Pasquale Rocco , Piombino Eliana , Campo Giorgia , Nicoletti Ferdinando , Cavalli Eugenio , Mangano Katia , Fagone Paolo
Published: January 2021

Discoid Lupus Erythematosus (DLE) is a chronic cutaneous disease of unknown etiology and of immunoinflammatory origin that is characterized by inflammatory plaques and may lead to disfiguring scarring and skin atrophy. Current treatments are limited, with a large proportion of patients either poorly or not responsive, which makes DLE an unmet medical need. Macrophage migration inhibitory factor (MIF) is the prototype of a pleiotropic family of cytokine that also includes the recently discovered homologue D-dopachrome tautomerase (DDT) or MIF2. MIF and DDT/MIF-2 exert several biological properties, primarily, but not exclusively of a proinflammatory nature. MIF and DDT have been suggested to play a key role in the pathogenesis of several autoimmune diseases, such as multiple sclerosis and type 1 diabetes, as well as in the development and progression of certain forms of cancers. In the present study, we have performed an immunohistochemistry analysis for the evaluation of MIF in DLE lesions and normal skin. We found high levels of MIF in the basal layer of the epidermis as well as in the cutaneous appendage (eccrine glands and sebocytes) of normal skin. In DLE lesions, we observed a significant negative correlation between the expression of MIF and the severity of inflammation. In addition, we performed an analysis of MIF and DDT expression levels in the skin of DLE patients in a publicly available microarray dataset. Interestingly, while these in silico data only evidenced a trend toward reduced levels of MIF, they demonstrated a significant pattern of expression and correlation of DDT with inflammatory infiltrates in DLE skins. Overall, our data support a protective role for endogenous MIF and possibly DDT in the regulation of homeostasis and inflammation in the skin and open up novel avenues for the treatment of DLE.
Seasonal Fe Uptake of Young Citrus Trees and Its Contribution to the Development of New Organs
Authors: Martínez-Cuenca Mary-Rus , Martínez-Alcántara Belen , Millos Jorge , Legaz Francisco , Quiñones Ana
Published: January 2021

This work quantifies Fe uptake in young citrus trees, its partitioning among plant compartments, and the contribution of the Fe absorbed from fertilizer to the development of new tissues. A soil pot experiment was conducted using 4-year-old clementine trees (Citrus clementina Hort ex Tan), and a dose of 240 mg Fe was applied by labeled fertilizer (92% atom 57Fe excess). Plants were uprooted at five different phenologic states: end of flowering (May 15), end of fruit setting and fruit drop (July 1), two fruit growing moments (August 1 and October 15), and at complete fruit maturity (December 10). The Fe accumulated in the root system exceeded 90% of the total Fe content in the plant. All organs progressively enriched with 57Fe (8.5–15.5% and 7.4–9.9% for young and old organs, respectively). Reproductive ones reached the highest increase (111% between May and October). 57Fe enrichment from woody organs reflects an increasing gradient to sink organs. The root system accumulated 80% of the Fe absorbed from the fertilizer, but the young organs accumulated relatively more Fe uptake during flowering and fruit setting (15.6% and 13.8%, respectively) than old organs (around 9.8%). Although iron derived from fertilizer (Fedff) preferably supplied young organs (16.7–31.0%) against old ones (2.5–14.9%), it only represented between 13.8% and 21.4% of its content. The use efficiency of the applied Fe (FeUE) barely exceeded 15%. The lowest FeUE were found in young and old organs of the aerial part (1.1–1.8% and 0.7–1.2%, respectively). Since the pattern of the seasonal absorption of Fe is similar to the monthly distribution curve of the supplied Fe, it is recommended that the application of Fe chelates in calcareous soils should be performed in a similar way to that proposed in this curve.
Pyrometallurgical Lithium-Ion-Battery Recycling: Approach to Limiting Lithium Slagging with the InduRed Reactor Concept
Authors: Windisch-Kern Stefan , Holzer Alexandra , Ponak Christoph , Raupenstrauch Harald
Published: January 2021

The complexity of the waste stream of spent lithium-ion batteries poses numerous challenges on the recycling industry. Pyrometallurgical recycling processes have a lot of benefits but are not able to recover lithium from the black matter since lithium is slagged due to its high oxygen affinity. The presented InduRed reactor concept might be a promising novel approach, since it does not have this disadvantage and is very flexible concerning the chemical composition of the input material. To prove its basic suitability for black matter processing, heating microscope experiments, thermogravimetric analysis and differential scanning calorimetry have been conducted to characterize the behavior of nickel rich cathode materials (LiNi0.8Co0.15Al0.05O2 and LiNi0.33Mn0.33Co0.33O2) as well as black matter from a pretreatment process under reducing conditions. Another experimental series in a lab scale InduRed reactor was further used to investigate achievable transfer coefficients for the metals of interest. The promising results show technically feasible reaction temperatures of 800 ∘C to 1000 ∘C and high recovery potentials for nickel, cobalt and manganese. Furthermore, the slagging of lithium was largely prevented and a lithium removal rate of up to 90% of its initial mass was achieved.
State-of-the-Art Char Production with a Focus on Bark Feedstocks: Processes, Design, and Applications
Authors: Şen Ali Umut , Pereira Helena
Published: January 2021

In recent years, there has been a surge of interest in char production from lignocellulosic biomass due to the fact of char’s interesting technological properties. Global char production in 2019 reached 53.6 million tons. Barks are among the most important and understudied lignocellulosic feedstocks that have a large potential for exploitation, given bark global production which is estimated to be as high as 400 million cubic meters per year. Chars can be produced from barks; however, in order to obtain the desired char yields and for simulation of the pyrolysis process, it is important to understand the differences between barks and woods and other lignocellulosic materials in addition to selecting a proper thermochemical method for bark-based char production. In this state-of-the-art review, after analyzing the main char production methods, barks were characterized for their chemical composition and compared with other important lignocellulosic materials. Following these steps, previous bark-based char production studies were analyzed, and different barks and process types were evaluated for the first time to guide future char production process designs based on bark feedstock. The dry and wet pyrolysis and gasification results of barks revealed that application of different particle sizes, heating rates, and solid residence times resulted in highly variable char yields between the temperature range of 220 °C and 600 °C. Bark-based char production should be primarily performed via a slow pyrolysis route, considering the superior surface properties of slow pyrolysis chars.
Binaural Modelling and Spatial Auditory Cue Analysis of 3D-Printed Ears
Authors: Ting Te Meng , Ahmad Nur Syazreen , Goh Patrick , Mohamad-Saleh Junita
Published: January 2021

In this work, a binaural model resembling the human auditory system was built using a pair of three-dimensional (3D)-printed ears to localize a sound source in both vertical and horizontal directions. An analysis on the proposed model was firstly conducted to study the correlations between the spatial auditory cues and the 3D polar coordinate of the source. Apart from the estimation techniques via interaural and spectral cues, the property from the combined direct and reverberant energy decay curve is also introduced as part of the localization strategy. The preliminary analysis reveals that the latter provides a much more accurate distance estimation when compared to approximations via sound pressure level approach, but is alone not sufficient to disambiguate the front-rear confusions. For vertical localization, it is also shown that the elevation angle can be robustly encoded through the spectral notches. By analysing the strengths and shortcomings of each estimation method, a new algorithm is formulated to localize the sound source which is also further improved by cross-correlating the interaural and spectral cues. The proposed technique has been validated via a series of experiments where the sound source was randomly placed at 30 different locations in an outdoor environment up to a distance of 19 m. Based on the experimental and numerical evaluations, the localization performance has been significantly improved with an average error of 0.5 m from the distance estimation and a considerable reduction of total ambiguous points to 3.3%.
Asymptotic Distributions for Power Variations of the Solutions to Linearized Kuramoto–Sivashinsky SPDEs in One-to-Three Dimensions
Authors: Wang Wensheng , Wang Dazhong
Published: January 2021

We study the realized power variations for the fourth order linearized Kuramoto–Sivashinsky (LKS) SPDEs and their gradient, driven by the space–time white noise in one-to-three dimensional spaces, in time, have infinite quadratic variation and dimension-dependent Gaussian asymptotic distributions. This class was introduced-with Brownian-time-type kernel formulations by Allouba in a series of articles starting in 2006. He proved the existence, uniqueness, and sharp spatio-temporal Hölder regularity for the above class of equations in d=1,2,3. We use the relationship between LKS-SPDEs and the Houdré–Villaa bifractional Brownian motion (BBM), yielding temporal central limit theorems for LKS-SPDEs and their gradient. We use the underlying explicit kernels and spectral/harmonic analysis to prove our results. On one hand, this work builds on the recent works on the delicate analysis of variations of general Gaussian processes and stochastic heat equation driven by the space–time white noise. On the other hand, it builds on and complements Allouba’s earlier works on the LKS-SPDEs and their gradient.
Augmenting the Role of Tourism Governance in Addressing Destination Justice, Ethics, and Equity for Sustainable Community-Based Tourism
Authors: Dangi Tek , Petrick James
Published: January 2021

Sustainable tourism development (STD) serves as a founding and guiding concept that can be applied to all forms of tourism, whereas community-based tourism (CBT) has been largely practiced as an alternative form of tourism development. Past research has suggested critical theoretical and practical omissions in both STD and CBT related to issues of community well-being, justice, ethics, and equity. With an objective of bridging these gaps, this research developed an integrated framework of sustainable community-based tourism (SCBT) based on a comprehensive literature review, which identified that there was a significant under-representation of key elements such as justice, ethics, and equity in the domain of governance both in the STD and CBT literatures. The qualitative research mixed emergent data with theory driven data and conducted semi-structured interviews with 40 diverse tourism stakeholders in the twin cities of Bryan–College Station (BCS) in Texas. Results revealed that tourism helped to promote cultural preservation and community pride and promoted the sense of mutual respect and understanding among visitors and stakeholders. However, some ethnic minorities felt they were not receiving full benefits of tourism. The study concluded that a more proactive, inclusive, ethic of care oriented tourism governance to help ensure sustainable tourism development is needed.
Seroprevalence of Antibodies against Diphtheria, Tetanus and Pertussis in Adult At-Risk Patients
Authors: Boey Lise , Bosmans Eline , Ferreira Liane Braz , Heyvaert Nathalie , Nelen Melissa , Smans Lisa , Tuerlinckx Hanne , Roelants Mathieu , Claes Kathleen , Derdelinckx Inge , Janssens Wim , Mathieu Chantal , Van Cleemput Johan , Vos Robin , Desombere Isabelle , Vandermeulen Corinne
Published: January 2021

Patients with chronic diseases are at increased risk of complications following infection. It remains, however, unknown to what extend they are protected against vaccine-preventable diseases. We assessed seroprevalence of antibodies against diphtheria, tetanus and pertussis to evaluate whether current vaccination programs in Belgium are adequate. Antibody titers were assessed with a bead-based multiplex assay in serum of 1052 adults with chronic diseases. We included patients with diabetes mellitus type 1 (DM1) (n = 172), DM2 (n = 77), chronic kidney disease (n = 130), chronic obstructive pulmonary disease (COPD) (n = 170), heart failure (n = 77), HIV (n = 196) and solid organ transplant (SOT) recipients (n = 230). Factors associated with seroprevalence were analysed with multiple logistic regression. We found seroprotective titers in 29% for diphtheria (≥0.1 IU/mL), in 83% for tetanus (≥0.1 IU/mL) and 22% had antibodies against pertussis (≥5 IU/mL). Seroprotection rates were higher (p < 0.001) when vaccinated within the last ten years. Furthermore, diphtheria seroprotection decreased with age (p < 0.001). Tetanus seroprotection was less reached in women (p < 0.001) and older age groups (p < 0.001). For pertussis, women had more often a titer suggestive of a recent infection or vaccination (≥100 IU/mL, p < 0.01). We conclude that except for tetanus, the vast majority of at-risk patients remains susceptible to vaccine-preventable diseases such as diphtheria and pertussis.
Dysuria Associated with Non-Neoplastic Bone Hyperplasia of the Os Penis in a Pug Dog
Authors: Maeta Noritaka , Shimokawa Miyama Takako , Kutara Kenji , Kanda Teppei , Mitsui Ikki , Ohnishi Akihiro , Miyabe Masahiro , Shimizu Yuki , Saeki Kaori , Okamura Yasuhiko , Yamazoe Kazuaki
Published: January 2021

A three-year-old male Pug presented with a three-year history of urolithiasis and repeated urethral obstruction. Biochemical analysis, ultrasonography, and retrograde urethrocystography revealed probable portosystemic shunt and incomplete urethral obstruction due to uric acid ammonium calculi. Enhanced computed tomography (CT) revealed portosystemic shunt and proliferation of the osseous tissue of the os penis, which was surgically removed. Histopathologically, the excised osseous tissue comprised bland lamellar bone without atypia or inflammation. Hyperplasia of the os penis was diagnosed based on the image findings and histopathology. The dysuria improved postoperatively. This is the first report of dysuria associated with non-neoplastic bone hyperplasia of the os penis in a dog. Careful evaluation of the os penis by CT is needed for accurate diagnosis in case of repeated penile urethral obstruction.
Enfermos pobres: Clasificaciones estatales, diferenciación social y acceso al bienestar en los años treinta (Córdoba-Argentina)
Authors: Ortiz Bergia María José
Published: January 2021

Las agencias estatales en contacto con la población ejecutan rutinariamente operaciones de clasificación destinadas a diferenciar a las personas y modelar su acceso a bienes materiales y simbólicos. Ahondando sobre esta acción burocrática, en este artículo analizamos las categorías estatales elaboradas para definir a los beneficiarios de las noveles políticas sanitarias construidas a partir de los años 1930, indagando quiénes fueron los encargados de crearlas, a quiénes incluyeron y excluyeron y qué sentidos les fueron otorgados. La exploración de esos procedimientos clasificatorios nos permitirá constatar que la utilización de viejas categorías sociales como las de “pobre” y “pudiente” sustentaron tempranos y duraderos procesos de focalización de las políticas de salud pública.
La Sociedad Criolla Dr. Elías Regules: el resurgimiento gauchesco en Uruguay (1935-1944)
Authors: Casas Matías Emiliano
Published: January 2021

La primera asociación tradicionalista de América se fundó en 1894 bajó la denominación de “Sociedad Criolla”. Elías Regules fue el gestor de ese movimiento que se transformó en referencia ineludible para el criollismo rioplatense. Este artículo se focaliza en la dinámica experimentada por la agrupación a partir de mediados de la década del treinta luego de un interregno provocado por el fallecimiento de su fundador. Se considera que tanto las condiciones generadas por el golpe de Estado de 1933 como la vinculación con tradicionalistas argentinos vigorizaron el renacimiento de “La Criolla” en Montevideo y promovieron un resurgimiento gauchesco en el Uruguay. A partir de los estatutos, reglamentos y libros evocativos editados, la prensa masiva y la revista Cimarrón, su órgano de difusión, se pretende dar cuenta de la refundación de la Sociedad Criolla Dr. Elías Regules. Se analiza cómo impactó ese proceso en las narrativas originarias de la agrupación, en las modalidades prácticas, en los vínculos con instituciones locales, en los diálogos con las agrupaciones argentinas, y en las proyecciones hacia la sociedad uruguaya.
Reseñas
Authors: Santos Lepera Lucía , Castro Gutiérrez Felipe , Cardonetti Stefanía , Belini Claudio , Zanca José , González Bracco Mercedes
Published: January 2021

Reseña de Mazzoni, María Laura (2019). Mandato divino, poder terrenal. Administración y gobierno en la diócesis de Córdoba del Tucumán (1778-1836). Rosario: Prohistoria, 204 páginas. Por LUCÍA SANTOS LEPERA

Reseña de Ibarra, Antonio, Álvaro Alcántara, Fernando Jumar (coords.). (2018). Actores sociales, redes de negocios y corporaciones en Hispanoamérica, siglos XVII-XIX. México: Universidad Nacional Autónoma de México / Bonilla Artigas Editores, 344 páginas. Por FELIPE CASTRO GUTIÉRREZ

Reseña de María Bjerg (2019) Lazos Rotos. La inmigración, el matrimonio y las emociones en la Argentina entre los siglos XIX y XX. Quilmes: Editorial de la Universidad Nacional de Quilmes, 128 páginas. Por STEFANÍA CARDONETTI

Reseña de Norma Lanciotti y Andrea Lluch (2018). Las empresas extranjeras en Argentina desde el siglo XIX al siglo XX. Buenos Aires: Imago Mundi, 282 páginas. Por CLAUDIO BELINI

Reseña de Leandro Losada (2020). Maquiavelo en la Argentina. Usos y lecturas, 1830-1940. Buenos Aires: Katz Editores, 2020, 196 páginas. Por JOSÉ ZANCA

Reseña de Pastoriza, Elisa y Torre, Juan Carlos (2019) Mar del Plata, un sueño de los argentinos. Buenos Aires: Edhasa, 360 páginas. Por MERCEDES GONZÁLEZ BRACCO.
A methodology of multimodal corpus creation for audio-visual speech recognition in assistive transport systems
Authors:   St. Petersburg Federal Research Center of the Russian Academy of Sciences, Axyonov A.A. , Ivanko D.V. , Lashkov I.B. , Ryumin D.A. , Kashevnik A.M. , Karpov A.A.
Published: January 2021

This paper introduces a new methodology of multimodal corpus creation for audio-visual speech recognition in driver monitoring systems. Multimodal speech recognition allows using audio data when video data are useless (e.g. at nighttime), as well as applying video data in acoustically noisy conditions (e.g., at highways). The article discusses several basic scenarios when speech recognition in the vehicle environment is required to interact with the driver monitoring system. The methodology defi nes the main stages and requirements for the design of a multimodal building. The paper also describes metaparameters that the multimodal corpus must correspond to. In addition, a software package for recording an audiovisual speech corpus is described.
Pemodelan Regresi Nonparametrik dengan Estimator Spline Truncated vs Deret Fourier
Authors: Dani Andrea Tri Rian , Adrianingsih Narita Yuri
Published: January 2021

ABSTRAKPendekatan regresi nonparametrik digunakan apabila hubungan antara variabel prediktor dan variabel respon tidak diketahui polanya. Spline truncated dan deret Fourier merupakan estimator dalam pendekatan nonparametrik yang terkenal, karena memiliki fleksibilitas yang tinggi dan mampu menyesuaikan terhadap sifat lokal data secara efektif. Penelitian ini bertujuan untuk mendapatkan estimator model regresi nonparametrik terbaik menggunakan spline truncated dan deret Fourier. Metode estimasi kurva regresi nonparametrik dilakukan dengan menyelesaikan optimasi Ordinary Least Squares (OLS). Kriteria kebaikan model menggunakan GCV, R2 dan MSE. Pemodelan regresi nonparametrik diterapkan pada data Case Fatality Rate (CFR) akibat Demam Berdarah Dengue (DBD) di Indonesia.  Berdasarkan hasil analisis, hasil estimasi dari pemodelan regresi nonparametrik menunjukkan bahwa estimator spline truncated memberikan performa yang lebih baik dibandingkan estimator deret Fourier. Hal ini ditunjukkan dengan nilai R2 dari estimator spline truncated yaitu sebesar 91,80% dan MSE sebesar 0,04, sedangkan dengan estimator deret Fourier diperoleh nilai R2 sebesar 65,44% dan MSE sebesar 0,19.ABSTRACTThe nonparametric regression approach is used when the relationship between the predictor variable and the response variable is unknown. Spline truncated and Fourier series are well-known estimators in the nonparametric approach because they have high flexibility and are able to adjust to the local properties of the data effectively. This study aims to obtain the best nonparametric regression model estimator using the truncated spline and the Fourier series. The nonparametric regression curve estimation method is done by completing the Ordinary Least Squares (OLS) optimization. The criteria for the goodness of the model use GCV, R2, and MSE. Nonparametric regression modeling is applied to Case Fatality Rate (CFR) modeling due to Dengue Hemorrhagic Fever (DBD) in Indonesia. Based on the analysis, the estimation results from the nonparametric regression modeling show that the truncated spline estimator provides better performance than the Fourier series estimator. This is shown by the R2 value of the truncated spline estimator which is 91.80% and the MSE is 0.04, while the Fourier series estimator obtained an R2 value of 65.44% and MSE of 0.19.
Assessment of Yalova University Campus according to LEED V.4 certification system
Authors: Erbıyık Hikmet , Çatal Tuğçe , Durukan Sinem , Topaloğlu Doğan Güneş , Ünver Ümit
Published: January 2021

In this paper, a detailed literature review on the LEED Certification system is embedded in to green building certification case study. Within the study, information about the parameters of the LEED system and the algorithm that should be applied in order to get full score from the audit were compiled. The conditions of Turkey were taken into account through the study. The study was presented in an analytical order for scientists to easily access information about the LEED Certification system. In addition, the evaluation required to get an appropriate score from the LEED certification system is given with a case study; analysis Yalova University Campus.
EVALUATION OF THE TEACHER PROFESSIONAL EDUCATION PROGRAM (PPG): ENGLISH STUDENTS’ PERSPECTIVE
Authors: Daud Afrianto , Novitri Novitri , Hardian Mirza
Published: January 2021

This study aims to document the assessment of alumni of teachers professional education program (PPG) in Riau University on the effectiveness of the PPG program in preparing prospective professional English teachers. All alumni of the 2018 subsidized PPG program at the University were selected as the sample of this study (15 people). Data was collected through the distribution of a Google form-based survey which was adopted from the PPG program evaluation questionnaire from the Ministry of Education, Higher Education. This study found that from the curriculum aspect, 84.6% of alumni said that the PPG curriculum content was in accordance with the needs of pre-service English teachers. However, 76.9% of participants stated that most of the material had been studied when they were in the undergraduate program. In terms of learning facilities, only 23.1% answered that they were satisfied with PPG facilities. 46.2% of them stated that the lecture room was not feasible. From the aspect of organizing services to students, only 42.6% said they were satisfied. The rest answered simply enough. From the aspect of the impact of the program, 69.2% of participants admitted that PPG had a significant impact on the development of their teaching profession. The greatest impact is on the aspect of both professional and pedagogical competencies. Thus, even though PPG is generally considered to be running quite well and has a positive impact, there are several aspects that need to be the attention of PPG organizers for the improvement of PPG in the future.
Pola Penerapan Sistem ‘ngabdi’ yang Dilakukan Pondok Pesantren Bahrul Maghfiroh Malang dalam Konteks Manajemen Sumber Daya Manusia
Authors: Septiawan Bambang , Adib Mawardi Muhammad , Rizal Muhammad
Published: January 2021

This study aims to analyze the pattern of implementing the 'ngabdi' system applied to the Bahrul Mahfiroh Islamic Boarding School in the context of HRM. This research is actually focused on the development of human resources in the Islamic boarding school Bahrul Maghfiroh Malang. This is very interesting because there is an integration between pesantren culture and HRM theory which is carried out in the economic and business spheres. In addition, acculturation of human resource development theory and Islamic boarding school culture is also discussed in this study. One of the ways to serve the pesantren is to increase the quality of the output of the students. The method used is a qualitative approach and is included in the descriptive scope because it describes the phenomena that occur in this study. The Miles and Huberman approach model is adopted for the data analysis technique performed. The results prove that 'ngabdi' also applies the HRM theory even though several factors are acculturated with the wisdom of the pesantren itself. In general, the implementation pattern of service in Bahrul Maghfiroh applies the HRM theory starting from recruitment, training, compensation, and termination of employment, although there are modifications according to the needs of the pesantren
Características operativas de técnicas moleculares empleadas para la detección del virus del papiloma humano en el proyecto ESTAMPA
Authors: Lineros-Hurtado Johana Andrea , Romero-Romero Pilar , Salgado-Lerma Yuly Milena , Wiesner-Ceballos Carolina
Published: January 2021

El desarrollo e innovación de nuevas tecnologías ha permitido mejorar la detección de la infección por el virus del papiloma humano de alto riesgo. Captura de híbridos II es un ensayo que se basa en hibridación y quimioluminiscencia. Cobas VPH Test es una PCR cualitativa y Aptima VPH Assay permite detectar la expresión de ARN mensajero de las oncoproteínas E6/E7 del VPH de alto riesgo. Estas técnicas presentan ventajas, en comparación, con la citología convencional que se utiliza como prueba de rutina para la detección temprana del cáncer de cuello uterino. En el estudio ESTAMPA, se realizaron 13.691 procesamientos que permitieron identificar que para el planteamiento de proyectos de investigación o para la implementación de pruebas de tamizaje de VPH es necesario analizar las ventajas y desventajas de las pruebas del mercado.
ОБЫДЕННЫЕ ПРЕДСТАВЛЕНИЯ О ЛЮБВИ ЖЕНЩИН И МУЖЧИН ПОЖИЛОГО ВОЗРАСТА
Authors: Былинская Наталья
Published: January 2021

В статье излагаются результаты исследования представлений о любви, существующих в сознании пожилых людей. Известно, что представления людей о любви формируются на основе обыденного житейского опыта, обретенного в процессе социального взаимодействия. В научной литературе представлены описания разных типов любви: любовь матери к ребенку, любовь к Богу, эротическая любовь, братская любовь, любовь-симпатия и дружба, любовь-привязанность, любовь-долг, любовь к самому себе и пр. Изучение структуры и содержания обыденных представлений о любви позволило зафиксировать их специфику у женщин и мужчин пожилого возраста. В обыденном сознании пожилых женщин присутствует два вида любви: идеальная любовь, в которой присутствуют счастье, доверие, смысл жизни, и любовь-дружба. Мужчины пожилого возраста ассоциируют любовь с чувственными отношениями между мужчиной и женщиной. Они называют любовь двигателем мира, славным, великим, нежным чувством, переживание которого может быть болезненным и требовать самоотречения. Среди многообразия типов любви, описанных в научной литературе, в обыденном сознании пожилых людей четко дифференцируются только отдельные ее виды. Женщинами любовь идеализируется и ассоциируется либо с дружбой, либо с верой во Всевышнего, мужчинами же любовь воспринимается как отношение полов.
ОСОБИСТІСНА ЗРІЛІСТЬ МАЙБУТНІХ ВЧИТЕЛІВ ЯК МЕХАНІЗМ ФОРМУВАННЯ ЇХ ПРОФЕСІЙНОЇ ІДЕНТИЧНОСТІ
Authors: Созонюк Ольга
Published: January 2021

Стаття присвячена психологічному аналізу особистісної зрілості як необхідної умови успішного розвитку професійної ідентичності та становлення вчителя. Особистісна зрілість майбутнього вчителя є комплексною характеристикою особистості майбутнього спеціаліста, що забезпечує свідоме прийняття здобувачем вищої освіти професійно значущих цінностей та його прагнення реалізувати себе у процесі професійної підготовки. Особистісна зрілість майбутнього фахівця є результатом засвоєння соціальнокультурних норм в умовах творчої взаємодії викладачів і студентів у навчально-виховному процесі вищої школи та виступає у майбутньому фактором професійного становлення особистості. Формування особистісної зрілості є важливим механізмом розвитку професійної ідентичності майбутніх учителів, а саме таких її структурних компонентів як Я-концепція, мотивація досягнення та здатність до психологічної близькості з іншими людьми.
ОСОБЛИВОСТІ ПРОЯВУ ОСОБИСТІСНИХ ХАРАКТЕРИСТИК МОЛОДШИХ ШКОЛЯРІВ ІЗ РІЗНИМ СОЦІОМЕТРИЧНИМ СТАТУСОМ У КЛАСІ
Authors: Хомич Іванна
Published: January 2021

Стаття присвячена дослідженню особливостей прояву моральних характеристик молодших школярів в залежності від соціометричного статусу в класі з урахуванням наукових підходів до вказаної проблеми. В ході експериментального дослідження підтвердилася гіпотеза про ймовірний вплив означеної групуючої змінної (соціометричного статусу в класі) на рівень вираженості інтегральних особистісних факторів молодших школярів, а саме факторів «морально-ціннісного відношення» та «ціннісного відношення до справ, обов’язків та інших людей». Вказані фактори найвищих середніх значень досягають у категорії молодших школярів з високим соціометричним статусом в класі («зірки»), демонструючи пік найнижчих середніх значень у категорії досліджуваних з низьким соціометричним статусом в класі («ізольовані»). Це означає, що значення усіх психологічних шкал, що структурно і змістовно визначають специфіку даних інтегральних особистісних факторів, лінійно зростають від категорії досліджуваних з найнижчим соціометричним статусом в класі до категорії досліджуваних з найвищим соціометричним статусом, що свідчить про зорієнтованість представників з найвищим соціометричним статусом у класі на морально-етичні цінності у поведінці.
Penerapan Algoritma Naive Bayes Untuk Mengklasifikasi Pengaruh Negatif Game Online Bagi Remaja Milenial
Authors: Asmiati Nungky , Fatmawati
Published: January 2021

In this modern era, the use of electronics such as cellphones, computers, laptops and others quite widely used for various needs. Information technology that is very developed today brings changes and affects social life. One of the problems in society is the large influence of online games because online games themselves have an attraction that makes people more fun playing than learning. It evidenced by the large number of millennial adolescents spending their daily time in front of computers or smartphones instead of books, and the lack of socializing is also one of the negative effects of playing online games and harms their health. To solve these problems, the classification method used is the naïve Bayes algorithm method, for classification in the form of online game user data as a whole, namely based on name, gender, age, number of days, duration and classification in the form of addiction and not addiction (normal). Therefore, this naïve Bayes algorithm can predict future opportunities based on past experiences. The results of the study of 100 online game user data in normal conditions were 78 respondents, and addiction was 22 respondents from the results of both concluded that the research results of millennial adolescents online game users were declared normal with an overall accuracy of 89.00%. Addicted recall class 77.27%, normal recall class 92.31%, addicted precision class 73.91%, normal precision class 93.51%.