bluuebunny/crossref_metadata_2025 huggingface dataset:
Herbal Hair Serum – A Promising Nourishing Agent for the Hair Growth
Authors: Yenurkar Yashshree N , Ingle Rahul G
Published: July 2024

With their promise of nourishing properties, improved scalp health, and stimulation of hair growth, herbal hair serums have become increasingly popular as natural substitutes for traditional hair care products. An overview of herbal hair serums is given in this abstract, with particular attention to their composition, effectiveness, safety, and possible advantages for hair health to the assertion of reduced hair loss and improved hair growth. Alopecia is a common issue among metropolitan dwellers who are subjected to stress, environmental issues, and other issues. Thus, we deduce from this review paper that alopecia may be effectively treated with numerous herbal remedies without any adverse effects. There are several allopathic medications kinds for treating hair loss, however they all have a lot of adverse effects. The foundation of any medical research is its herb collection. About 80% of residents suggested using herbal medications since they had fewer negative effects and more positive effects than the animal system. Our article shows that herbal hair serum contains a number of vital ingredients that are necessary to maintain the correct operation and self-defense. It also offers excellent protection from extreme heat. Many factors have contributed to the severe hair loss issues that the younger generations are now experiencing. Generally speaking, hair loss is not transient. Known to be the most significant organ in the mammalian system, the hair follicle has a variety of roles in self-defense, extreme temperature protection, and attractiveness and gender differentiation. The younger generations are facing severe hair loss issues as a result of several lifestyle changes, including worry, weariness, and overindulgence in junk food and hair colouring and styling products.t alopecia is the outcome. To encourage the production of new hair and prevention of hair loss, hair roots must be activated which is why many individuals experiencing hair loss are seeking different treatments. The anti-dandruff and hair care properties of Citrus sinensis are employed
Revolutionizing Arthritis Care: Cutting-Edge Nanogel Formulations for Targeted, Long-Lasting Relief and Enhanced Mobility
Authors: Gupta Saurabh , Malik Jitender  Kumar , Singh Gyan
Published: July 2024

Arthritis, which impacts individuals all over the globe, is characterized by severe pain and a high prevalence rate. Current treatments for the illness come with a number of obstacles and difficulties. It is necessary to explore alternative paradigms, as systemic medications aren’t necessarily the greatest choice. The new discipline of nanotechnology has the potential to significantly alter several aspects of arthritis treatment. Therefore, the work provides strong support for developing novel therapies employing compositions of topical nanogels. Traditional systemic narcotics have their limitations, and the evolution of arthritis treatments has to take that into consideration. Thus, novel nanogel formulations offered as a nanotechnology solution may out to be quite advantageous. Applying nanogels to product design has been a significant administrative step. Nanogels offer unparalleled precision and efficiency, whether you’re dealing with simple concepts, cutting-edge techniques for surface modification, or intricate strategies for drug encapsulation. New data from pain evaluations, clinical studies, and comparisons to traditional therapies have supported their revolutionary potential and effectiveness. However, the patient’s health must always come first. While we strive to mitigate adverse effects and evaluate long-term ramifications, the positive outcomes of our biocompatibility testing offer reassurance regarding the safety profile of nanogels. For regulatory and ethical considerations, there must be transparency, informed permission, and equitable access for nanotechnology-powered arthritic treatments. This study calls for additional research into the use of nanotechnology in the treatment of arthritis because recent advances in nanogel technology have the ability to completely transform the current approach to treating this debilitating disease, bringing about a new era of precision medicine.
Exploring the Therapeutic Potential of Lepidagathis pungens Nees Extracts as Novel Therapy Options in Streptozotocin and Nicotinamide-Induced Diabetes in Albino Wistar Rats
Authors: R Jothilakshmi , R Srinivasan
Published: July 2024

Diabetes mellitus remains a global health concern, necessitating innovative therapeutic approaches. This study explores the antidiabetic potential of aqueous and methanol extracts from Lepidagathis pungens Nees in albino Wistar rats induced with diabetes. Diabetes induction involves the administration of streptozotocin (STZ) and nicotinamide (NIC), mimicking pathological conditions observed in human diabetes. The study employed aqueous and methanol extracts of L. pungens Nees alongside a standard drug, glibenclamide. Diabetes induction was achieved through intraperitoneal injection of STZ and NIC. Extracts and the standard drug were orally administered, and various parameters, including blood glucose levels, body weight changes, insulin and hemoglobin levels, as well as liver and lipid profiles, were monitored at specified intervals. Furthermore, liver and pancreas tissues were evaluated histopathologically. In comparison to the diabetic group, both aqueous and methanol extracts demonstrated significant antidiabetic activity (p <0.001), with effects comparable to or better than the standard drug. A remarkable improvement in insulin and hemoglobin levels was observed, along with significant improvements in blood glucose levels and body weight changes. Furthermore, the extracts demonstrated positive effects on liver and lipid profiles, exhibiting potential to mitigate diabetes-induced complications. Histopathological studies revealed protective effects on liver and pancreas tissues, supporting the extracts’ therapeutic efficacy. In STZ- and NIC-induced diabetic rats, L. pungens Nees extracts show promising antidiabetic activity. The extracts demonstrated significant improvements in various physiological parameters, suggesting their potential as alternative or adjunctive therapies in the management of diabetes. Further research and clinical investigations are warranted to elucidate the underlying mechanisms and translate these findings into practical therapeutic applications.
Discovery of mTOR Receptor Modulators Targeting Breast Cancer by Hybrid of Virtual Screening and Molecular Docking Approach
Authors: Tajane Pravin , Deshmukh Swapnil , Lunkad Amit , Tare Manoj
Published: July 2024

This research paper presents a comprehensive approach integrating virtual screening and molecular docking to identify potential therapeutic candidates. Pharmacophore-based virtual screening was employed to assess the structural similarities of compounds to a reference molecule, revealing promising candidates with high similarity scores. Subsequently, molecular docking studies were conducted to predict the binding affinities of these compounds to the target receptor, 4DRH. CHEMBL3775006 emerged as a lead candidate, demonstrating both structural resemblance and strong binding affinity to the target protein. ADME studies highlighted its pharmacokinetic properties, while toxicity prediction studies provided insights into potential adverse effects. Overall, this study underscores the utility of virtual screening and molecular docking in identifying novel drug candidates with therapeutic potential.
Design and Discovery of Apigenin-based Drugs as a Potential Casein Kinase II Inhibitor for Breast Cancer through Hybrid In-silico Methods
Authors: Pund Swati , Tupe Asmita , Dhande Mayuri , Panchal Harshvardhan
Published: July 2024

This study investigates the potential of apigenin and derivatives as casein kinase II inhibitors for breast cancer treatment by a hybrid in-silico approach. Drug-drug transcriptomic similarity analysis reveals correlations with 17 drugs, guiding the identification of perturbagens with major transcriptional impressions. Transcriptional impact analysis across cell lines underscores apigenin’s dose-dependent influence on gene expression, particularly in breast cancer cells. Protein pre-preparation and molecular docking, refined by PDB REDO, showcase improved model quality and favorable binding affinities. Notable findings include apigenin’s potency as a CK2 inhibitor and promising compounds like dextromethorphan. Drug-drug transcriptomic similarity rankings identify potential candidates for further investigation. In conclusion, this integrated approach lays the groundwork for targeted therapies in breast cancer.
Computational Assessment of Viscum album Flavanones as Androgen Receptor Inhibitors for Prostate Cancer by Molecular Docking Approach
Authors: Pathak Leena , Patil Jayashri , Thorat Mahesh , Bhise Manish
Published: July 2024

This study presents a computational assessment of Viscum album flavanones as potential inhibitors of the androgen receptor (AR) for prostate cancer treatment. Molecular docking techniques were employed to evaluate the binding affinities and interaction profiles of ten bioactive flavanones found in V. album within the AR binding site. Hesperidin exhibited the highest binding affinity (-9.0 kcal/mol), followed by neohesperidin and naringin with binding affinities of -8.9 and -8.7 kcal/mol, respectively. Key interactions, including hydrogen bonding and hydrophobic contacts, were identified, highlighting the therapeutic potential of these compounds as AR inhibitors. Additionally, other flavanones such as hesperetin, taxifolin, and naringenin showed substantial binding affinities, while eriodictyol, sakuranetin, pinocembrin, and isosakuranetin exhibited moderate affinities. These findings suggest that V. album flavanones may serve as promising candidates for further experimental validation and clinical investigation in prostate cancer therapy.
Simultaneous Determination of Pyridoxine HCl, Isoniazid, Trimethoprim and Sulfamethoxazole by Double Divisor Ratio Spectra Derivative Spectroscopic Method
Authors: Kansara Kush Prashant , Dave Hiral Narendra
Published: July 2024

Tuberculosis could be regarded as a serious and enduring menace to global health. A significant hurdle in tuberculosis treatment lies in drug resistance, including the emergence of multiple drug resistance. A regulatory agency has recently endorsed the fixed-dose combination of pyridoxine HCl, isoniazid, trimethoprim, and sulfamethoxazole as a robust therapy for cases of tuberculosis resistant to multiple drugs. Therefore, a successful attempt was made to develop and validate a novel spectroscopic method, i.e., double deviation ratio spectra derivative spectroscopic method, for the simultaneous determination of pyridoxine HCl, Isoniazid, trimethoprim, and sulfamethoxazole in their pure form. The optimized divisor concentration in the developed method was found to be a mixture of 6 μg/mL of sulfamethoxazole and 16 μg/mL of pyridoxine HCl for the determination of isoniazid and trimethoprim in the same quaternary mixture. Similarly, the optimized divisor concentration for the determination of sulfamethoxazole and pyridoxine HCl was found to be a mixture of isoniazid and trimethoprim with concentrations of 10 and 12 μg/mL, respectively. With the developed method, the linearity for pyridoxine HCl, isoniazid, trimethoprim, and sulfamethoxazole was found to be in the range of 8 to 40 μg/mL, 10 to 30 μg/mL, 12 to 36 μg/mL, and 4 to 12 μg/mL, respectively. The results of the accuracy study, in terms of percentage recovery, were found to be 99.92 ± 0.978, 100.04 ± 1.731, 99.87 ± 1.811, and 98.83 ± 0.922 for the simultaneous determination of pyridoxine HCl, isoniazid, trimethoprim, and sulfamethoxazole, respectively, using the developed method. The developed method has been successfully validated as per the ICH guidelines.
Synthesis, Characterization and Antimicrobial Evaluation of New Substituted Thiazolidinones Bearing Triazole Moiety
Authors: SG Jawarkar , MD Game
Published: July 2024

Series of thiazolidinone derivatives containing triazole moiety have been synthesized by condensing various substituted aldehydes to form Schiff bases which further reacts with thioglycolic acid undergoes ring condensation to form 3-(3-mercapto-5-((5-methoxy-1H-indol-1-yl)methyl)-4H-1,2,4-triazol-4-yl)-2-substituted phenylthiazolidin-4-one followed by reaction with ethyl chloroacetate to form ethyl 2-((4-(2-subtituted phenyl-4-oxothiazolidin-3-yl)-5-((5-methoxy-1H-indol-1-yl)methyl)-4H-1,2,4-triazol-3-yl)thio)acetate. The synthesized compounds were characterized by elemental analysis, fourier-tranform infrared spectroscopy (FTIR), nuclear magnetic resonance (NMR) and mass spectrometry. All synthesized compounds were evaluated for invitro antibacterial activity against Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, Pseudomonas aeruginosa and for antifungal activity against Candida albicans, Aspergillus niger. The results of synthesized compounds showed that T-III, T-IX, T-X, and T-XVIII have antimicrobial activity when compared to standard drugs. The compounds having p-bromo, p-chloro, p-methoxy and p-nitro groups showed potent antimicrobial agent
A Network Pharmacology-based Approach to Explore Potential Targets and Mechanism of Berberis aristata Focusing on its Implications for Diabetes Mellitus
Authors: Bethi Siddartha , Patil Jayashri , Thube Ujjwala , Patil Khushabu
Published: July 2024

Berberis aristata, a revered medicinal shrub in traditional systems like Ayurveda, holds promise in managing diabetes mellitus, a burgeoning global health concern. Through a comprehensive analysis of its bioactive compounds and their interactions with potential targets, this study elucidates the molecular mechanisms underlying its anti-diabetic effects. Screening through databases yielded 17 bioactive compounds, including rutin, quercetin, and berberine. Protein-protein interaction analysis identified 44 potential targets, with 36 genes overlapping with disease-related genes, indicating pivotal pathways in diabetes mellitus treatment. Further, pathway analysis highlighted G-protein coupled receptor signaling, calcium signaling, and neurotransmitter receptor activity as significant, with adjusted p-values. Network analysis revealed key hub genes like DRD1 and MMP2, emphasizing their central role in Berberis aristata’s therapeutic action. The findings underscore Berberis aristata’s potential as a source of novel anti-diabetic agents and offer groundwork for potential research in this field.
Mental Disorders – A Serious Global Concern that Needs to Address
Authors: Chaudhari Khushi S , Dhapkas Mayur P , Kumar Amit , Ingle Rahul G
Published: July 2024

A major global health concern that affects millions of individuals globally is mental illness. Recent estimates place the number of people with mental or behavioral disorders at 450 million worldwide, making up over 12% of all diseases (Friedrich, 2017). These issues include substance use disorders, bipolar disorder, schizophrenia, depression, and concern disorders, among many other conditions. It is projected that 322 million people worldwide, or 4.4% of the total population, suffer from depression alone. These figures were featured in the report “Depression and Other Common Mental Disorders: Global Health Estimates,” released by the World Health Organization (WHO) in 2017. The prevalence of anxiety disorders, which currently affect 260 million individuals worldwide, or 3.6% of the total population, is another topic covered in the report. The consequences of mental diseases are prevalent in low and mid-income countries as well; they are not exclusive to high-income ones. According to the report, mental health issues are rising in these countries
Drug Diversion: Could be a Serious Concern in Global Healthcare System
Authors: Dhapkas Mayur P , Chaudhari Khushi S , Kumar Amit , Ingle Rahul G
Published: July 2024

Prescription drug diversion is a significant $25 billion-a-year problem in the US. Diversion can occur at any stage of the medicine delivery process, from manufacturing to the patient. Common diversion methods include illegal selling by doctors/pharmacists, “doctor shopping,” theft/forgery of prescriptions, and burglaries/thefts. Emerging diversion methods include theft by healthcare workers, fraud involving insurance, and theft from medicine cabinets. The main sources of diverted medications are at the practitioner-patient level, such as through “doctor shopping” and friends/family sharing prescriptions. Diversion from healthcare settings like hospitals accounts for a smaller proportion, though the exact extent is difficult to quantify. Some diversion occurs through theft from pharmacies, manufacturers, and supply chain points, but this makes up a relatively small percentage. Healthcare providers who engage in drug diversion have been linked to infectious disease outbreaks in hospitals, exposing patients to pathogens like hepatitis C. Intelligent systems and machine learning can help rapidly detect diversion anomalies. Comprehensive solutions are needed, including policy reforms, communication strategies, and a public health approach.
Natural Products Could be a Promising Remedy against Biofilm-Forming Bacteria
Authors: Khandalkar Gaurav G , Ugemuge Pooja K , Ingle Rahul G
Published: July 2024

A biofilm is a typical form of naturally occurring bacterial development. Biofilm development could be responsible for developing resistance to harmful environmental conditions, such as developing immunity to antibiotics, medicine and other antibacterial agents (e.g., methicillin, vancomycin, etc). The quorum sensing (QS) process is essential for biofilm development and for preserving environmental equilibrium when bacterial numbers increase. Finding novel antibacterial medications that can regulate the development and expansion of biofilms is imperative because these structures are closely related to the appearance of multidrug and extended drug (e.g., tuberculosis) resistance and infectious illnesses. Natural plant-based chemicals have been found in an increasing amount of studies over the past 20 years to have antibacterial and chemo-preventive properties in the parameter of biofilm growth. The present article will include some herbs with unknown bioactive ingredients or unclear processes, as well as current findings on the identification of natural anti-biofilm chemicals from plants with known molecular addresses or mechanisms. The authors are also focused on developing techniques for locating and isolating naturally occurring anti-biofilm agents. Anti-biofilm treatments awaiting clinical trials are also reviewed. The currently identified natural anti-biofilm compounds are auspicious and may present novel therapeutic strategies for biofilm-associated illnesses
Multifocal Cryptococcus Neoformans Osteomyelitis in a Kidney Transplant Recipient
Authors: Chauhan Sanshriti , Gulati Sanjeev , Naorem Gopendro Singh
Published: July 2024

Cryptococcal infections are notoriously difficult to diagnose and have been associated with high morbidity and mortality. Cryptococcus neoformans presenting as osteomyelitis is an unexpected clinical scenario in the transplant ward. A young male who underwent spousal kidney donor transplantation 16 months ago presented with painful and ulcerated soft tissue in upper and lower limbs which were diagnosed as cryptococcus osteomyelitis. He was managed with surgical debridement, liposomal amphotericin B, flucytosine and reduction in maintenance immunosuppression (IS). To our knowledge this is the first reported case of multifocal cryptococcus osteomyelitis in a kidney transplant recipient.
ANALISIS FINANCIAL DISTRESS MENGGUNAKAN METODE ALTMAN, SPRINGATE, ZMIJEWSKI DAN INTERNAL GROWTH RATE PADA PERUSAHAAN TELEKOMUNIKASI YANG TERDAFTAR DI BURSA EFEK INDONESIA
Authors: Jamil Poppy Camenia , Asâ€™ad Iffa Vadilla
Published: July 2024

Telecommunications service providers are competing to get clients to utilize their services due to the rapid advancement of technology. If, on the other hand, the company is unable to compete, it will go bankrupt. The Altman Z-score, Springate, Zmijewski, and Internal Growth Rate models were used to determine the probability of bankruptcy in telecommunications businesses listed on the BEI. This research uses descriptive analysis method with quantitative approach. The population in this study were telecommunication companies listed on the Indonesia Stock Exchange by using purposive sampling method to obtain 5 telecommunication companies, namely PT Bakrie Telcom Tbk, PT XL Axiata Tbk, PT Smartfren Tbk, PT Indosat Tbk, and PT Telkomunikasi Indonesia Tbk. Data were analyzed using Altman, Springate, Zmijewski, and Internal Growth Rate methods. The results showed that of the five most consistently good companies overall, PT Telekomunikasi Indonesia, three could still be said to survive, and one company (PT Bakrie Telcom) was declared to be in a state of crisis or financial difficulty.
ANALISIS PENERAPAN AKUNTANSI PADA KOPERASI KONSUMEN PEGAWAI REPUBLIK INDONESIA XYZ
Authors: Putri Veronika Anggia , Saputra Dian
Published: July 2024

This research was conducted at the XYZ Republic Of Indonesia Employee Consumer Cooperative. This study aims to determine whether the application of accounting ar cooperative is in accordance with generally accepted accounting principles. The data used are primary data an secondary data. Data collection techniques used are interviews and documentation. Several deficiencies can be found in this study, some of these deficiencies ar that cooperatives places risk fund accounts in current liabilities, and cooperatives do not explain reserve funds in the Notes To Conslidated Financial Statements. After conducting research on cooperative, it can be concluded that the application of accounting to the XYZ Republic Of Indonesia Employee Consumer Cooperative is not accordance with generally accepted accounting principles.
Budget credit and financial control over it
Authors: Алиханова Р.А. , Мусаева А.М. , Курбанов С.А.
Published: July 2024

В данной статье автор рассматривает контрольные мероприятия в Республике Дагестан. А именно контрольные мероприятия в части проверки использования республикой средств инфраструктурного бюджетного кредита. В своем Послании Федеральному Собранию Российской Федерации от 21 апреля 2021 г. Президент Российской Федерации озвучил предоставление субъектам Российской Федерации принципиально нового инструмента развития, так называемые инфраструктурные бюджетные кредиты. Об этом и о многом другом описано в статье.
The modern concept of the "knowledge economy" in the context of a new paradigm of economic development
Authors: Маккаева Р.С. , Асхабалиев И.Ч. , Омаров М.М.
Published: July 2024

В статье представлен обширный обзор современной концепции "экономики знаний" в условиях новой парадигмы экономического развития. Подробно анализируются основные принципы экономики знаний, включая признание знаний как ценного ресурса, учет интеллектуального капитала, процессы генерации, передачи и применения знаний, а также необходимость развития образования и культуры инноваций. Обращается особое внимание на факторы, способствующие развитию экономики знаний. В этом контексте рассматриваются важность технологического прогресса и информационных технологий, которые играют ключевую роль в создании, передаче и хранении знаний. Отдельное внимание уделяется значению образования, науки, инноваций, исследований, а также взаимодействия между различными секторами и международного сотрудничества для развития экономики знаний. Также освещает вызовы и препятствия, которые могут возникнуть на пути развития экономики знаний. Неравенство в доступе к информации и знаниям, угрозы безопасности информации, защита интеллектуальной собственности и барьеры внедрения и использования знаний - все эти факторы могут ограничить развитие экономики знаний. Автор предлагает возможные стратегии и решения для преодоления этих вызовов. В заключении статьи приводятся примеры успешной реализации концепции экономики знаний. Сингапур, Финляндия, Силиконовая долина и компания IBM являются выдающимися примерами, где принципы экономики знаний успешно применяются для достижения экономического прогресса и конкурентного преимущества.
Digital education and digital transformation
Authors: Джафарова З.К. , Погорелова Л.А.
Published: July 2024

Статья посвящена вопросам развития цифрового образования на современном этапе. В статье даны основные термины цифровизации и цифровой трансформации, цифрового и дистанционного образования. Проведены различия между перечисленными понятиями. Перечислены общие проблемы и негативы цифрового образования, а также плюсы его развития. Определены основные пути решения таких проблем, как кадровая необеспеченность в IT сфере, дана характеристика рискам личной безопасности в цифровом пространстве, а также выявлены риски физического здоровья молодого поколения при полном переходе на дистанционное цифровое обучение.
DEVELOPMENT OF AN INNOVATIVE TAXATION MODEL FOR SMALL BUSINESSES IN THE RUSSIAN FEDERATION
Authors: Шаталова О.И. , Снегирева Н.В. , Тимофеева С.Н. , Демченко И.А. , Ледовская А.В.
Published: July 2024

Налоговое регулирование и стимулирование инновационной деятельности являются одним из важнейших элементов системного рассмо- трения проблемы эффективности государственной финансовой политики. Поэтому данная проблема имеет актуальность и требует особого внимания. Ключевые слова: налоговое регулирование, инновационная деятель- ность, малый бизнес, модели.
FACTOR STRUCTURES OF INTELLECTUAL AND PERSONAL RESOURCE OF YOUNG PEOPLE
Authors: Алисова Х.Х. , Айгумов Т.Г.
Published: July 2024

В настоящей статье рассматривается актуальная в настоящее время проблематика влияния на формирование в онтогенезе интеллектуально-личностного ресурса множества различных факторов, одним из которых являются сложившиеся отношения в родительской семье. Интеллектуально-личностный ресурс рассматривается как комплексный показатель, включающий различные аспекты интеллекта и личностных характеристик, которые влияют на успешность и адаптивность молодых людей в современном обществе. Для достижения этой цели был проведен обзор литературы и проведено эмпирическое исследование образовательного сообщества молодых людей с использованием стандартизированных психологических тестов, по результатам которого найдены подтверждения обусловленности развития интеллектуально-личностного ресурса молодых людей особенностями его факторной структуры.
COST-EFFECTIVENESS EVALUATION ALGORITHM FOR PROCESS OPTIMIZATION AT MANUFACTURING ENTERPRISES
Authors: Тлеугабылов К.Т.
Published: July 2024

Алгоритм позволяет проводить прогноз и оценку эффективности программы оптимизации производственных операций в стоимостном выражении и определять диапазон снижения издержек. Алгоритм возможно гибко настраивать как для отдельных операций, так и участков, цехов и всей организационной системы. Выводы. Обсуждение результатов показало, что алгоритм не вызывает споров о результатах, позволяет проводить прогноз стоимостной эффективности оптимизационных и кризисных мероприятий быстро и беспристрастно. Алгоритм применяется при проведении антикризисных мероприятий, реструктуризации производственных предприятий, а также при подготовке к привлечению инвестиций или сделкам M&A.
VARIOUS CONDITIONS AND FEATURES OF WRITING OFF FINANCIAL LIABILITIES AND MONETARY DEBTS
Authors: Чернова С.А. , Ашуралиева Д.Р.
Published: July 2024

В данной статье авторы рассматривают различные пути спи- сания задолженности. Задолженность - сумма финансовых обязательств и денежных долгов, которую нужно погасить, вернуть в определенный срок. От того, кем является учреждение - поставщиком или получателем товаров, ра- бот, услуг зависит тип задолженности - дебиторская или кредиторская. Об этом и о многом другом описано в статье.
Improving the mechanism for managing sustainable development of rural areas
Authors: Громов Е.И. , Шаталова О.И. , Цуциева О.Т.
Published: July 2024

В статье рассмотрены теоретико – методические по разработке механизма управления устойчивым развитием сельских территорий; рассмотрены проблемы социально-экономического характера жизнедеятельности в сельской местности; вопросы формирования эффективного управленческого инструментария рассмотрены с позиции функционирования трёх взаимосвязанных подсистем – экономической, социальной и экологической. В процессе исследования были разработаны предложения по оптимизации управленческой деятельности в аспекте обеспечения устойчивости развития сельских территорий.
SOME ASPECTS OF STATE POLICY IN THE SPHERE OF EMPLOYMENT
Authors: Эфендиева Д.С.
Published: July 2024

Максимальная занятость и всемерное обеспечение населения работой решают такие глобальные проблемы нашего времени как растущее социальное неравенство и бедность. В данной статье исследуется вопрос государственной политики занятости в России в посткризисный период. Актуальность данной тематики стала значительно выше по той причине, что коронавирусная пандемия сильно повлияла на рынок труда России и мира. Автором обобщены меры, принимаемые государством в регулировании занятости и по предотвращению увеличения уровня безработицы.
PROSPECTS AND PROBLEMS OF REGIONAL ECONOMIC DEVELOPMENT IN THE DIGITAL AGE
Authors: Лолаев Б.Б. , Омаров З.З.
Published: July 2024

В данной статье рассматриваются актуальные вопросы, свя- занные с развитием региональных экономик в условиях цифровой трансфор- мации. Цифровая эпоха предоставляет регионам уникальные возможности для увеличения производительности, привлечения инвестиций и улучшения качества жизни жителей. Однако она также сопряжена с вызовами, такими как неравномерное распределение доступа к цифровым технологиям, кибер- безопасность, подготовка рабочей силы и управление данными. Рассмотрены политика и стратегии развития региональной экономики в цифровую эпоху, включая государственную поддержку, развитие инфра- структуры, образование и обучение, стимулирование инноваций и предпри- нимательства. Приведены примеры успешных региональных инициатив, такие как "Силиконовая долина" в Калифорнии, город Таллин в Эстонии, Мальмё в Швеции и израильский технологический парк "Матам", которые ил- люстрируют, как цифровые технологии могут поддерживать экономический рост и инновации в регионах. Создание эффективных стратегий и политики, а также обмен успешны- ми практиками между регионами, имеет важное значение для обеспечения устойчивого и успешного развития региональных экономик в эпоху цифровой трансформации.
CHANGES IN THE RUSSIAN BUDGET ACCOUNTING
Authors: Магомедова Р.Д. , Ибрагимова А.Х.
Published: July 2024

Бюджетное учреждение – организация, созданная органами государственной власти РФ, к которым относятся учреждения образования, культуры, здравоохранения, организации государственного управления, во- енно-промышленного комплекса и армии. Обязательным условием отнесе- ния организации к разряду бюджетной является бюджетное финансирование по смете и ведение бухгалтерского учета по бюджетному плану счетов и в порядке, предусмотренном инструкциями. Бюджетный учет является важной учётной политикой государственных структур, главной целью деятельности которых считается не получение при- были. Для выделения средств из бюджета государства организация должна предоставлять полную отчётность по сметам доходов и расходов. Расходо- вание государственных средств постоянно отслеживается. Бюджетный учет является важным инструментом предоставления всех схем расчетов и дви- жений федеральных, муниципальных средств. Один раз в квартал требуется предоставлять от 5 до 10 видов отчетов. Годовая отчётность включает рас- ширенный список бланков от 10 до 30. [6]
ISSUES OF CURRENT TRENDS IN TAX AND ACCOUNTING
Authors: Джабраилова Н.Д. , Расулова Д.Р.
Published: July 2024

Данная статья раскрывает тенденции современного состоя- ния российского бухгалтерского и налогового видов учета. Авторами прове- ден анализ двух систем и сделан вывод о начале налогового учета на основе бухгалтерского. Приведены мнения исследователей в данной области, об их взаимосвязи и зависимости. Выявлены причины разделения бухгалтерского и налогового учета. Рассмотрена обширная нормативная база, доказываю- щая хаотичность обособления. Результатом, которого стала необеспеченность налогового учета теори- ей, вызывающей практические проблемы. Авторами выявлена негативная тенденция налогового учета, предложены пути совершенствования. Научная литература содержит споры об налоговом учете и степени его связи с бух- галтерским. Исследование позволило дать конкретные предложения по пути взаимодействия видов учета, через их независимость дающей возможность достижению их целей.
RCHITECTURE OF THE REGIONAL INNOVATION AND ENTREPRENEURIAL ECOSYSTEM AS THE BASIS FOR SUSTAINABLE DEVELOPMENT OF RUSSIAN REGIONS
Authors: ПАШКОВСКАЯ Е.Г.
Published: July 2024

Статья посвящена определению и формированию архитекту- ры региональных инновационно - предпринимательских экосистем (РИПЭ) как форм обеспечения устойчивого развития российских регионов. Предло- жено авторское определение РИПЭ как части национальной инновационной экосистемы, органично интегрированной в предпринимательскую среду ре- гиона и обеспечивающей эффективную технологическую трансформацию и расширение его бизнес - среды в целях устойчивого развития. Авторский подход к формированию архитектуры РИПЭ выделил в качестве ключевых элементов экосистемы: национальные стратегические основы устойчивого развития экономики, масштабируемые на региональный уровень; ядро эко- системы (госорганы, наука и бизнес); доверительное пространство (институ- циональная среда); цифровую платформу и модельно-методический инстру- ментарий. В обоснование архитектуры РИПЭ даны характеристики ключевых элементов экосистемы. В заключение отмечены перспективы развития пред- ложенной архитектуры РИПЭ.
THE ROLE OF THE ENGLISH LANGUAGE IN INTERNATIONAL COMMUNICATIONS
Authors: КАРИПИДИ А.Г. , МОРОЗ Д.Н.
Published: July 2024

Наличие языкового барьера при взаимодействии между стра- нами и народами с прошлых лет являлось одним из важных и актуальных глобальных проблем, но с появлением и овладением английским языком эти барьеры постепенно сходили на нет, перед обществом открывались новые горизонты, предоставляя возможность обладать одним из важных инстру- ментов без помощи которого люди не смогли бы взаимодействовать как меж- ду собой, так и с объектами, в разных сферах, к примеру, бизнес-деятельно- сти, торговых отношениях, развлекательной и научной сферах, дипломатии, а также коммуницировать с народами различных наций, что в настоящее вре- мя является крайне важным для профессионального и личностного развития – это всего лишь малая часть, обуславливающая значимость и неотъемле- мость, универсальность, рассматриваемого многофункционального инстру- мента предоставленного современному обществу.
ON THE ISSUE OF MODELING THE PROCESSES OF FORMING A MANAGEMENT TEAM OF AN ENTERPRISE
Authors: Александрова Л.Ю. , Лохонова Г.М. , Александрова О.С.
Published: July 2024

В современных условиях высокой неопределенности внешней среды система менеджмента играет все более важную роль в обеспечении устойчивой конкурентной позиции предприятия. Важной задачей менед- жмента является разработка и практическая реализация путей развития и повышения эффективности использования кадрового потенциала, в первую очередь управленческого, входящего в состав наиболее важных с произ- водственной и экономической точек зрения структур предприятия. Форми- рование управленческой команды, организация и оптимизация ее работы отражает ключевые этапы организационного менеджмента. Выявление сущ- ности и задач, этапов и проблем моделирования процессов формирования управленческой команды предприятия стало целью настоящего исследова- ния. Для ее достижения были применены методы теоретических обобщений, критический анализ, моделирование и различные способы классификации. Статья знакомит с научными подходами к понятию «управленческая ко- манда», раскрывает ее признаки и особенности (например, в ней отсутствуют иерархические подходы к взаимодействию, она формируется и развивает- ся одновременно, др.). В статье раскрыта значимость и задачи формирова- ния управленческой команды, как совокупности мероприятий по созданию группы влиятельных лиц предприятия для помощи собственнику в процес- сах принятия и реализации решений относительной всей организационной деятельности. Обоснована необходимость моделирования процессов фор- мирования управленческой команды. Раскрыто ее место в плоскости множе- ственных взаимодействующих факторов среды, предложена модель форми- рования команды с учетом их влияния. В ней прослеживается взаимосвязь между внешним окружением предприятия и целеполаганием.
Clustering of the Membrane Protein by Molecular Self-assembly Downregulates Signaling Pathway for Cancer Cell Inhibition
Authors: Li Ying , Hu Liangbo , Wang Jing , wang huaimin
Published: July 2024

This work reports a cyclic peptide appended self-assembled scaffold that recognizes the membrane protein EGFR and arrests the EGFR signaling by assembly induced aggregation through multivalent interactions. Being incubating with cells, the oligomers of PAD-1 first recognize overexpressed EGFR on cancer cell membrane for arresting EGFR, which then initiate cellular uptake through endocytosis. The accumulation of PAD-1 and EGFR in the lysosome results in the formation of nanofibers, leading to lysosomal membrane permeabilization (LMP). These processes disrupt the homeostatic of EGFR and inhibit the downstream signaling transduction of EGFR for cancer cell survive. Moreover, LMP induced the releasing of protein aggregates could generate endoplasmic reticulum (ER) stress, resulting in cancer cell death selectively. In vivo studies indicate the efficient anti-tumor efficiency of PAD-1 in tumor bearing mice. As a first example, this work provides an alternative strategy for controlling protein behavior for tuning cellular events in living cells.
Atomic-Precision Non-van der Waals 2D Structures: Superconductivity in π-d Conjugated Coordination Polymers
Authors: Pan Zhichao , Huang Xing , Fan Yunlong , Wang Shaoze , Liu Yiyu , Cong Xuzhong , Zhang Tingsong , Qi Shichao , Xing Ying , Zheng Yu-Qing , Li Jian , Zhang Xiaoming , Xu Wei , Sun Lei , Wang Jian , Dou Jin-Hu
Published: July 2024

Two-dimensional conjugated coordination polymers (2D c-CPs) exhibit exceptional charge transport properties. Among them, copper-based benzenehexathiol coordination polymer (Cu-BHT) is a rare superconductor. However, the precise atomic structure of Cu-BHT remains elusive, hindering the understanding of the origin of superconductivity in 2D c-CPs. Here, single crystals of Cu3BHT with the high crystallinity have been achieved, revealing a quasi-2D kagome structure with non-van der Waals interlayer Cu-S covalent bonds. Cu3BHT single crystal exhibits intrinsic metallic behavior, with conductivity reaching 10E3 S/cm at 300 K and 10E4 S/cm at 2 K. Notably, superconductivity in Cu3BHT crystals was observed for the first time at 0.25 K, attributed to the enhanced electron-electron interactions and electron-phonon coupling induced by non-van der Waals 2D structures. The discovery of this clear correlation between atomic-precise crystal structure and electrical properties lays a crucial foundation for the emergence of new superconductor CPs, aiming for revolutionizing the future quantum devices.
THERMOMETER IONS, INTERNAL ENERGIES, AND AMBIENT IONIZATION IN-SOURCE FRAGMENTATION
Authors: Bertrand Emilie , Gabelica Valérie
Published: July 2024

Ionization and fragmentation are at the core of mass spectrometry. But they are not separated in space, as in-source fragmentation can also occur. Here we survey the literature published since our 2005 review on the internal energy and fragmentation in electrospray ionization sources (Gabelica & De Pauw, Mass Spectrom. Rev. 2005, 24, 566). We present new thermometer molecules to diagnose and quantify source heating, provide tables of recommended threshold (E0) and appearance energies (Eapp) for the survival yield method, and systematically compare the softness of a variety of ambient pressure ionization methods. The droplet size distribution and desolvation dynamics play a major role: lower average internal energies are obtained when the ions remain protected by a solvation shell and spend less time nakedly exposed to activating conditions in the transfer interface. Methods based on small droplet formation without electrophoretic charging can thus be softer than electrospray. The tuning of the entire source interface often has an even greater influence on ion internal energies and fragmentation than on the ionization process itself. We also highlight new dielectric barrier discharge sources that can gas-phase ionize small molecules while conferring barely more internal energy than electrospray ionization. We hope that this review will facilitate the control and standardization of in-source ion activation conditions, to ensure the transferability of data and research results in mass spectrometry.
Bioresponsive pseudoGlucosinolates (psGSLs) release Isothiocyanates (ITCs) in the Presence of Nitroreductases
Authors: Jimidar Claire C. , Ganskow Charity S. G. , Kagho Mervic D. , Chakrabarti Aishi , Wiese Lorenz , Zollo Michael , Beutling Ulrike , Cesar Leona C. , Morud Julia , Brönstrup Mark , Sieber Stephan A. , Hacker Stephan M. , Klahn Philipp
Published: July 2024

Glucosinolates (GSLs) are secondary metabolites produced as part of an herbivore defence system in plants of the order Brassicales. GSLs release isothiocyanates (ITCs) upon activation by the myrosinase. Beyond their herbivore feeding deterrent properties, these ITCs have multiple interesting bioactivities. However, their release is limited by the presence of myrosinase. Here, we report the concept of pseudoglucosinolates (psGSLs) hijacking the natural release mechanism of GSLs for the release of ITCs and adapting it to nitroreductase as the triggering enzymes. We provide proof-of-concept for nitroreductase-responsive psGSLs and demonstrate their potential for peptide labelling, ITC-prodrug approaches and for in vivo applications using the nematode of C. elegans.
Effects of Ligand Chemistry on Ion Transport in Two-Dimensional Hybrid Organic-Inorganic Perovskites
Authors: Wei Grace , Kaplan Alan , Zhang Hang , Loo Yueh-Lin , Webb Michael
Published: July 2024

Two-dimensional (2D) hybrid organic-inorganic perovskites are potentially promising materials as passivation layers that can enhance the efficiency and stability of perovskite photovoltaics. The ability to suppress ion transport has been proposed as a stabilization mechanism, yet effective characterization of relevant modes of halide diffusion in 2D perovskites is nascent. In light of this knowledge gap, we combine molecular dynamics simulations with enhanced sampling and experimental validation to systematically characterize how ligand chemistry in seven (R-NH3)2PbI4 systems impacts halide diffusion, particularly in the out-of-plane direction. We find that increasing stiffness and length of ligands generally inhibits ion transport, while increasing ligand polarization generally enhances it. Structural and energetic analyses of the migration pathways provide quantitative explanations for these trends, which reflect aspects of the disorder of the organic layer. Overall, this mechanistic analysis greatly enhances the current understanding of halide migration in 2D hybrid organic-inorganic perovskites and yields insights that can inform the design of future passivation materials.
Tuning the Electronic Properties of Azophosphines as Ligands and their Application in Base-Free Transfer Hydrogenation Catalysis
Authors: Jordan Emma , Calder Ethan , Greene Bethan , Adcock Holly , Male Louise , Davies Paul , Jupp Andrew
Published: July 2024

The design and tuning of new ligands is crucial for unlocking new reactivity at transition metal centres. Azophosphines have recently emerged as a new class of 1,3-P,N ligands in ruthenium piano-stool complexes. This work shows that the azophosphine synthesis can tolerate N-aryl substituents with strongly electron-donating and electron-withdrawing para-R groups, and that the nature of this R group can affect the spectroscopic and structural properties of the azophosphines, as measured by NMR spectroscopy, UV-Vis spectroscopy, single crystal X-ray diffraction and DFT studies. Azophosphines are shown to be relatively weak phosphine donors, as shown by analysis of the 1JP–Se coupling constants of the corresponding azophosphine selenides, but the donor properties can be fine-tuned within this area of chemical space. Monodentate and bidentate Ru-azophosphine complexes were prepared, and their first use as catalysts was probed. The Ru-azophosphine complexes were found to promote the transfer hydrogenation of acetophenone to 1-phenylethanol without the requirement of a harsh base additive, and the bidentate complex was more active than the monodentate analogue.
Formulation and evaluation of amoxapine mucoadhesive buccal films
Authors: Sk. Mahaboob Ali , KV Swathi Krishna , R Gautham Chakra
Published: July 2024

Among innovative drug delivery methods, buccal mucoadhesive systems have been attracting much interest recently because of their capacity to stick to the oral mucosa, stay there, and gradually release their drug content. By improving medication absorption through the oral mucosa and reducing the hepatic first-pass impact, buccal mucoadhesive films can increase the drug's bioavailability and enhance its therapeutic effect. The current study aimed to synthesize the medicine as a buccal bioadhesive film, which reduces the frequency of dosage form administration by releasing the drug at a sufficient concentration over time. Because this formulation is simple to administer and requires no water to swallow, improved patient compliance is one of its benefits. Dissolving profile as investigated in USP dissolving apparatus type 1 using saliva at pH 6.8. The impact of factors such as polymer type, concentration, and release profile of Amoxapine was investigated. The formulation was optimized Based on several evaluation criteria, including drug content and in-vitro drug release. Formulation F6 successfully releases the drug in 7 hours. The stability studies followed ICH recommendations, and the results showed that the optimized formulation was stable. The IR spectra demonstrated the stable qualities of Amoxapine in a mixture of polymers utilized and revealed the absence of interaction between the drug and the selected polymer.
Present challenges and surveillance of artificial intelligence in neuro-oncology
Authors: R Gautham Chakra , K Kavyanjali , D Sree , SK Shaima , B Govardhan
Published: July 2024

Brain tumors are evaluated, characterized, and monitored using diagnostic imaging. However, because these tumors are so diverse, there are still several difficulties in each group. This might involve differences in the biology of the cancer that are linked to varying intensities of cellular invasion, proliferation, and necrosis, all of which have distinct imaging appearances. Due to these changes, tumor evaluation, including segmentation, surveillance, and molecular characterizations, has become more complex. Even though various rule-based techniques have been put into practice to relate to tumor appearance and size, these techniques naturally reduce the vast quantity of tumor imaging data to a small number of variables. Due to their efficacy in resolving image-based problems, approaches in artificial intelligence, machine learning, and deep learning have found increased use in computer vision tasks, such as tumor imaging. This section aims to provide an overview of some of these developments in tumor imaging.