bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation of PD-1 and interleukin-10-receptor expression by T lymphocytes in malignant and benign pleural effusions
Authors: Mosleh Berta , Hammer Barbara , El-Gazzar Ahmed , Kramer Markus , Ayazseven Seda , Bernitzky Dominik , Geleff Silvana , Idzko Marco , Gompelmann Daniela , Hoda Mir Alireza
Published: April 2024

Background:
PD-1 (programmed cell death protein-1)/PD-L1 (programmed cell death ligand-1) as well as IL-10 (interleukin-10)/IL-10R (interleukin-10 receptor) interactions play a major role in tumor immune evasion in various malignancies. Several studies investigated the expression of PD-1 on T lymphocytes in pleural effusions (PE) in patients with malignant diseases. However, results in malignant pleural effusions (MPE) compared to benign PE (BPE) are underreported.
Methods:
In this prospective study, 51 patients (median age 66 years, IQR 54–78, 47% male) with PE of malignant or benign origin were enrolled and divided into three groups according to the cytological results (group 1: MPE [n = 24, 47%]; group 2: BPE in malignant disease [n = 22, 43%]; group 3: BPE in benign disease [n = 5, 10%]). In the cytological samples, T cells were analyzed for the expression of PD-1 and IL-10R via flow cytometry.
Results:
In MPE, the proportion of PD-1 + T lymphocytes on CD4 + cells was significantly lower than in BPE (group 1 vs 3, p = 0.019). Moreover, a significantly lower expression of PD-1 + IL-10R + CD8+ (group 1 vs 2, p = 0.016; group 1 vs 3, p = 0.032) and a significantly higher expression of PD-1-IL-10R-CD8 + T lymphocytes (group1 vs 2, p = 0.045; group 1 vs 3, p = 0.032) were observed in MPE when compared to BPE.
Conclusion:
The frequency of T cells expressing PD-1 and IL-10R is significantly lower in MPE compared to BPE regardless of the underlying disease indicating a different microenvironment in PE driven by the presence of tumor cells. Our observation spotlights the possible involvement of PD-1 and IL-10R in MPE.
Non-wounding Contact-based Inoculation of Fruits with Fungal Pathogens in Postharvest
Authors: Sbodio Adrian Oscar , Mesquida-Pesci Saskia Desiree , Yip Nancy , Alvarez-Rojo Isabela , Gutierrez-Baeza Elia , Tay Samantha , Bello Pedro , Wang Luxin , Blanco-Ulate Barbara
Published: April 2024

Background Fungal pathogens significantly impact the quality of fruits and vegetables at different stages of the supply chain, leading to substantial food losses. Understanding how these persistent fungal infections occur and progress in postharvest conditions is essential to developing effective control strategies.
Results In this study, we developed a reliable and consistent inoculation protocol to simulate disease spread from infected fruits to adjacent healthy fruits during postharvest storage. We tested different combinations of relevant fruit commodities, including oranges, tomatoes, and apples, against impactful postharvest pathogens such as Penicillium digitatum, Penicillium italicum, Botrytis cinerea, and Penicillium expansum. We assessed the efficacy of this protocol using fruits treated with various postharvest methods and multiple isolates for each pathogen. We optimized the source of infected tissue and incubation conditions for each fruit-pathogen combination. Disease incidence and severity were quantitatively evaluated to study infection success and progression. At the final evaluation point, 80% or higher disease incidence rates were observed in all trials except for the fungicide-treated oranges inoculated with fungicide-susceptible Penicillium spp. isolates. Although disease incidence was lower in that particular scenario, it is noteworthy that the pathogen was still able to establish itself under unfavorable conditions, indicating the robustness of our methodology. Finally, we used multispectral imaging to detect early P. digitatum infections in oranges before the disease became visible to the naked eye but after the pathogen was established.
Conclusions We developed a non-invasive inoculation strategy that can be used to recreate infections caused by contact or nesting in postharvest. The observed high disease incidence and severity values across fruit commodities and fungal pathogens demonstrate the robustness, efficacy, and reproducibility of the developed methodology. The protocol has the potential to be tailored for other pathosystems. Additionally, this approach can facilitate the study of fruit-pathogen interactions and the assessment of innovative control strategies.
Antenatal care practices for gestational weight gain: a cross sectional survey of antenatal care providers reported provision and barriers to providing recommended care
Authors: Hollis Jenna L , Deroover Kristine , Daly Justine , Tully Belinda , Foster Michelle , Lecathelinais Christophe , Pennell Craig E , Wiggers John , Kingsland Melanie
Published: April 2024

Background: Implementation of recommended gestational weight gain (GWG) care by antenatal care providers is poor. It is unclear whether practice implementation and barriers Tadiffer between antenatal care provider profession or experience. This study aimed to assesses the provision of and barriers to guideline care for GWG and examine associations with professional discipline and years of experience.
Methods: A cross sectional survey was conducted with antenatal care providers working in three public maternity services in a regional city in Australia. Data were collected on the provision of and barriers (informed by the Theoretical Domains Framework) to recommended GWG care. Data were summarised using descriptive statistics. Associations between health profession characteristics (professional discipline and years providing antenatal care) and GWG care practices and barrier outcomes were assessed using multivariate logistic regression.
Results:117 antenatal care providers completed the survey (75% participation rate). One quarter (25%) reported that they routinely provided recommended GWG assessment at the first antenatal visit, and 9% at subsequent visits. Only 7% routinely provided recommended advice on GWG, healthy eating and physical activity. Professional discipline or years of experience were not associated with higher odds of GWG practices. Skills, belief about capabilities, belief about consequences and environmental context and resources were barriers to providing care. Medical professionals had higher odds of agreeing that they have been adequately trained to address GWG (OR = 9.14, 95%CI:3.10-26.90) and feel competent in having sensitive conversations with pregnant women about GWG (OR = 8.60, 95%CI:2.29-32.28) than midwives. Midwives had higher odds of agreeing that there are services they can refer pregnant women to for further support (OR = 2.80, 95%CI:1.13-6.91).
Conclusions:The provision of antenatal care for GWG was low, inconsistently provided and did not differ by professional discipline or years of experience. Antenatal care providers report numerous barriers including skills, belief about capabilities, belief about consequences, and environmental context and resources. Barriers to GWG care provision differed by professional discipline, but not years of providing care. The findings demonstrate that the type and prioritisation of practice-change implementation strategies may need to be tailored to address the differential barriers faced by professional groups.
Predictive numerical modeling of the behavior of asphalt-core rockfill dam
Authors: Estación Oscar , Pinyol Nuria , Olivella Sebastià , Lopez Marko
Published: April 2024

The construction of large dams with asphalt concrete core and shoulders of Rockfill is becoming more and more common in many countries around the world. This article focuses on the Yele dam (China) with a height of 124.5 m. Filling material and monitoring measures during the construction and impoundment are available. A hydro-mechanical analysis coupled with the finite element method with Code_Bright software is used. The constitutive parameters were obtained by back-analysis from triaxial tests using an elastoplastic model for Rockfill materials, while a viscoelastic is used to model the core asphalt. According to the numerical modelling, the collapse effect is due for impounding and effect of wetting. The results were compared with the geotechnical instrumentation measure available.
Compositional Changes and Ecotoxicological Aspects of Hydrogen Peroxide Application to a Natural Plankton Community
Authors: Santos Allan Amorim , Silva Luan de Oliveira , Azevedo Sandra Maria Feliciano de Oliveira e , de Magalhães Valéria Freitas , Pacheco Ana Beatriz Furlanetto
Published: April 2024

Cyanobacterial blooms compromise water quality worldwide, demanding nutrient input control. However, once established, other strategies are necessary to control the growth of cyanobacteria. Oxidation processes such as hydrogen peroxide (H2O2) offer a potential solution; however, research on planktonic community recovery post-H2O2 exposure is limited. Here, we investigated the impact of the addition of H2O2 alone at various concentrations (1, 10, and 100 mg/L) on the natural phytoplankton and bacterioplankton communities of a eutrophic reservoir over 21 days under laboratory conditions. We aimed to evaluate the differential susceptibility of cyanobacteria and green algae, possible phytoplankton regrowth, changes in bacterioplankton composition and the effect of residual H2O2 or its byproducts on organisms at different trophic levels. Initially, cyanobacteria (mainly Microcystis and Cyanobium) were the main contributors to chlorophyll (Chl) concentrations, followed by green algae. Within 7 days, the phytoplankton abundance decreased under all conditions, with pronounced effects occurring in the H2O2 treatments within the first 48 hours. H2O2 exposure led to residual Chl concentrations for cyanobacteria and green algae, and after fresh culture medium addition, green algae, but not cyanobacteria, were able to regrow in the <10 mg/L treatment. At lower H2O2 concentrations, Microcystis, Cyanobium, Limnothrix, and Planktothrix resisted, while at higher concentrations, Cyanobium and Mastigocladopsis persisted. In the bacterioplankton community, H2O2 addition led to a greater abundance of taxa from the hgcI clade, Comamonadaceae family, Craurococcus-Caldovatus and Staphylococcus. Ecotoxicological assays revealed transient effects of H2O2 on Daphnia similis survival, while Danio rerio remained unaffected. Our findings demonstrate that, compared with cyanobacteria, green algae exhibit greater resistance and resilience to H2O2, with transient effects on zooplankton at concentrations up to 10 mg/L. This research underscores the complexity of managing cyanobacterial blooms and emphasizes the need for comprehensive strategies considering ecological impacts.
Tumor-naïve pre-surgical ctDNA detection is prognostic in clinical stage I lung adenocarcinoma
Authors: Hong Tae Hee , Hwang Soohyun , Dasgupta Abhijit , Abbosh Christopher , Hung Tiffany , Bredno Jörg , Walker Jill , Shi Xiaojin , Milenkova Tsveta , Horn Leora , Choi Joon Young , Lee Ho Yun , Cho Jong Ho , Choi Yong Soo , Shim Young Mog , Chai Shoujie , Rhodes Kate , Roychowdhury-Saha Manami , Hodgson Darren , Kim Hong Kwan , Ahn Myung
Published: April 2024

We assessed pre-surgical diagnostic circulating tumor DNA (ctDNA) status in 895 patients with EGFR/ALK-wild-type, clinical stage I–II non-small-cell lung cancer using a tumor-naïve methylation-based cell-free DNA assay. Pre-surgical ctDNA detection was observed in 55/414 (13%) patients with clinical stage I lung adenocarcinoma (LUAD) and was associated with poor recurrence-free survival (RFS) (2-year RFS 69% versus 91%; log-rank P < 0.001), approaching that of clinical stage II LUAD. Pre-surgical ctDNA detection was not prognostic in patients with clinical stage II LUAD or non-LUAD. Within LUAD, tumor volume interacted with positron emission tomography avidity to predict pre-surgical ctDNA detection, and pre-surgical ctDNA detection correlated with high-grade pathological features, programmed death ligand-1 (PD-L1) positivity, and pathological upstaging. Our findings support pre-surgical ctDNA positivity as an adverse prognostic feature specifically in clinical stage I LUAD. This validated observation using a tumor-naïve assay will enable perioperative trial advances targeted toward patients with high-risk disease.
Computational Modeling of Regional Dynamics of Pandemic Behavior using Psychologically Valid Agents
Authors: Pirolli Peter , Teng Choh Man , Lebiere Christian , Mitsopoulos Konstantinos , Morrison Don , Orr Mark
Published: April 2024

Regional Psychologically Valid Agents (R-PVAs) are computational models representing cognition and behavior of regional populations. R-PVAs are developed using ACT-R—a computational implementation of the Common Model of Cognition. We developed R-PVAs to model mask-wearing behavior in the U.S. over the pre-vaccination phase of COVID-19 using regionally organized demographic, psychographic, epidemiological, information diet, and behavioral data. An R-PVA using a set of five regional predictors selected by stepwise regression, a psychological self-efficacy process, and context-awareness of the effective transmission number, Rt, yields good fits to the observed proportion of the population wearing masks in 50 U.S. states [R2 = 0.92]. An R-PVA based on regional Big 5 personality traits yields strong fits [R2 = 0.83]. R-PVAs can be probed with combinations of population traits and time-varying context to predict behavior. R-PVAs are a novel technique to understand dynamical, nonlinear relations amongst context, traits, states, and behavior based on cognitive modeling.
The Flooding of Lagash: Evidence for Urban Destruction under Lugalzagesi, the King of Uruk
Authors: Goodman Reed , Giosan Liviu , Shen Zhixiong , Lang Andreas , Zimmerman Paul , Constantinescu Stefan , Pizzimenti Sara , Alrawi Zaid , Pittman Holly
Published: April 2024

New research at Tell al-Hiba, ancient Lagash, has uncovered evidence of extensive flooding and sitewide destruction in the latter half of the third millennium BC. Specifically, we characterize and date a prominent water-formed feature that crosses the heart of Lagash’s former temple district. Geoarchaeological trenching and geophysical prospection indicate that the feature, consisting of a series of meander point and counterpoint bars, intercepted and overlies late Early Dynastic cultural materials, suggesting that upstream river avulsion resulted in the rapid and energetic fluvial sedimentation. Based on the site’s broader geomorphological context, this process would have played out widely across the city’s hinterland, leaving lasting consequences, including spatially extensive soil salinization and waterlogging. Additional archaeological, radiometric, and historical data allow us further to propose that this flooding likely developed during or shortly after Lagash was attacked by Lugalzagesi, a king of Uruk. In combination with the site’s surface ceramic record, our evidence indicates that much of the city’s population left in direct response. Ultimately, this work provides evidence of urban environmental devastation through warfare at an early period in time, and it also contributes to the chronometry of 3rdmillennium dynastic history in Mesopotamia.
Insilco analysis of an interaction between an endogenous peptide fragment of NUR77 receptor from human cells and USAG1 protein - may induce teeth regeneration
Authors: VAITHYANATHAN PRAKASH
Published: April 2024

BMP-7 and WNT signaling are responsible for the development of teeth. USAG-1 (uterine sensitization associated gene-1) inhibits bone morphogenetic protein-7 protein (BMP-7) as well as WNT receptors leading to suppression of tooth development and growth. The inhibition of USAG-1 using an antibody has been shown to induce tooth regeneration in mice. Hence, USAG-1 is a drug target that is promising enough for teeth generation. In this paper, for the first time, it has been proposed that an endogenous peptide that is part of the NUR-77 receptor in human cells may inhibit USAG-1 protein to induce tooth regeneration when injected locally. The peptide FSRSLHSL of the NUR-77 receptor interacts with the usag-1 protein through enough hydrogen bonds as shown by the docking studies. BCL-2 expression determines the mineralogical composition of enamel crystals of tooth structure. The peptide FSRSLHSL doesn’t convert the character of BCL-2 to proapoptotic although the addition of an extra amino acid “L” to derive FSRSLHSLL leads to an orthogonal behavior.
Centrality-based nearest-neighbor projected-distance regression (C-NPDR) feature selection for correlation predictors with application to resting-state fMRI of major depressive disorder
Authors: Kresock Elizabeth , Luttbeg Henry , Li Jamie , Kuplicki Rayus , McKinney B. A. , McKinney Brett , Dawkins Bryan
Published: April 2024

Background.
Nearest-neighbor projected-distance regression (NPDR) is a metric-based machine learning feature selection algorithm that uses distances between samples and projected differences between variables to identify variables or features that may interact to affect the prediction of complex outcomes. Typical bioinformatics data consist of separate variables of interest like genes or proteins. In contrast, resting-state functional MRI (rs-fMRI) data is composed of time-series for brain Regions of Interest (ROIs) for each subject, and these within-brain time-series are typically transformed into correlations between pairs of ROIs. These pairs of variables of interest can then be used as input for feature selection or other machine learning. Straightforward feature selection would return the most significant pairs of ROIs; however, it would also be beneficial to know the importance of individual ROIs.
Results.
We extend NPDR to compute the importance of individual ROIs from correlation-based features. We present correlation-difference and centrality-based versions of NPDR. The centrality-based NPDR can be coupled with any centrality method and can be coupled with importance scores other than NPDR, such as random forest importance. We develop a new simulation method using random network theory to generate artificial correlation data predictors with variation in correlation that affects class prediction.
Conclusions.
We compare feature selection methods based on detecting functional simulated ROIs, and we apply the new centrality NPDR approach to a resting-state fMRI study of major depressive disorder (MDD) and healthy controls. We determine that the areas of the brain that are the most interactive in MDD patients include the middle temporal gyrus, the inferior temporal gyrus, and the dorsal entorhinal cortex. The resulting feature selection and simulation approaches can be applied to other domains that use correlation-based features.
Adrenomedullin level in children with congenital adrenal hyperplasia: Relationship to vascular and left ventricular functions
Authors: Farghaly Hekma , Eltayeb Azza , Metwallley Kotb Abbas , Mohammad Shimaa kamal , Kandiel Randa A. , Saied GhadaMohamed ,   Azhar arabi Mohammed1
Published: April 2024

Purpose: To evaluate left venticular, vascular endothelial function and its association with adrenomedullin (AM) levels in children with classic CAH.
Methods: 42 children with classic CAH (mean age of 13.5±2.4 years) were compared to 42 healthy controls. Measurement of 17-hydroxy-progesterone, total testosterone, and AM levels were carried out. LV functions and cardiac dimensions were measured with traditional echocardiography. Brachial artery flow-mediated dilation (FMD%) and carotid intima-media thickness (CA-IMT) were measured via vascular ultrasonography. According to the control on medical treatment, patients were classified into poor (n = 12) and good (n = 30) controlled groups.
Results: Patients had significant higher AM levels and LVM index (LVMI), while lower brachial FMD%, a thicker CA-IMT, and a prolonged mitral deceleration time (DcT) in relation to controls. These changes were marked in children with poorly controlled on medical treatment. In multivariate analysis, AM levels were significantly correlated with systolic (OR =; 95% ) and diastolic blood pressures (OR = 2.9; 95% ), Testosterone ( OR =3.46; 95% CI = 1.55-2.13, ), LVMI (OR = 2.6; 95% CI: 1.1– 1.13), mitral DcT (OR = 2.4; 95% CI: 1.15–2.05; ), CA-IMT (OR = 1.6; 95% CI: 1.16–1.57) ,and FMD% (OR =2.6; 95%CI = 1.33-2.89) .
Conclusions: AM level was elevated in children with classic CAH, especially in those not well controlled on medical treatment, and it was correlated with LVMI, mitral DcT, CA-IMT, and FMD%. Children with CAH who are at increased risk of developing subclinical CV problems may benefit from measuring AM level.
New Mineral Names
Authors: Olds Travis A. , Emproto Christopher
Published: April 2024

This issue of New Mineral Names provides a summary of the newly described minerals from 2023 and selected information for recent descriptions from October to December of 2023. New mineral name trends and observations are presented using an objective, data-driven, and curated examination of new mineral species and their broader implications.
Impact of Critical Success Factors on International ISO Accreditation for the Botswana Public Health Laboratories
Authors: Moitlhobogi Bakae , Maruta Talkmore
Published: April 2024

The purpose of this study is to identify critical success factors and their impact on implementation of quality management system at selected Public Health Laboratories in Botswana. The study population was from the targeted seven accredited Public Health Laboratories in Botswana. Data on critical success factors was collected using a questionnaire. The questions were based on the critical success factors for implementation of total quality management identified during the literature review. Ten Critical Success Factors for successful implementation of the quality management system were rated by a group of questions using a five point Likert scale method. The 5-point Likert scale includes the items: strongly agree, agree, neutral, disagree, and strongly disagree. Strongly agree was assigned a score of 5, agree is assigned a score of 4, neutral is assigned a score of 3, disagree is assigned a score of 2 and strongly disagree a score of 1. The mean of the assigned ratings is 3.0. Critical success factors which score mean greater than 3.0 will be classified as agree while those mean less than 3.0 will be classified as disagree. All the ten critical success factors had a mean above of 3.0, with a range of 4.77 to 3.57. All the ten success factors were deemed critical; Employee empowerment Strategic quality planning, Process management, Performance management, Quality culture, Management and leadership, Training, Supplier Management, Customer focus, Information analysis.
Climate Change-Related Drivers of Migration in East Africa: An Integrative Review of the Literature
Authors: Chetto Reginald , Mdemu Makarius , Kihila Jacob
Published: April 2024

Despite the growing academic concern and policy interest in climate change drivers of migration, scientific evidence on the topic remains contested, with divergent claims of positive and negative contributions of climate change on human migration and displacement. This review seeks to assess the climate change-related drivers of migration with a focus on three East African countries: Tanzania, Kenya, and Uganda. They are among the most vulnerable countries in Africa, with one of the most mobile populations. The study used the available literature on climate change and migration as the data source. About 22 research articles on climate change and migration were sourced from the Web of Science and Scopus databases and critically reviewed.  The review generally indicates that climate change effects such as frequent drought and flood disasters, livestock pests, and crop diseases influence migration and displacement in the region. On the other hand, rising sea levels pose imminent risks that can cause migration if adaptation measures are not taken. The review has also revealed that responses to drought or livestock and crop diseases, be it localized adjustment or out-migration, are determined by households' adaptive capacity. For rapid onset climate events such as floods, the most vulnerable are the less fortunate living in poorly constructed structures in flood-prone zones. This review proposes strengthening the climate policy framework by mainstreaming climate change migration in East African nations’ adaptation plans. It also calls for promoting alternative livelihood activities as an adaptation strategy in areas prone to climate change to lessen human-forced migration and displacement.
A value-based framework from Building Stock Model to Retrofit Model
Authors: Flores Ivett
Published: April 2024

The study has as its original database the decarbonization process initiated in Mexico by the National Commission for the Efficient Use of Energy (CONUEE) as part of its “Savings Program of Electric Power in Buildings of the Federal Public Administration” (PAEIAPF) of 1999. The primary purpose of PAEIAPF was to reduce the levels of electric power consumption in Federal Government buildings. The program has operated for 20 years; however, its scope only reaches operational carbon.
Since 90% of existing buildings will be in use by 2050, the Retrofit Models will be the base to determine solutions for a more resilient living environment that fortifies and extends the grid’s capacity and meets climate change mitigation targets.
Secondly, significant socioeconomic and profound environmental impacts are not calculated explicitly in existing tools and are often referred to as “secondary” or Non-Energy Benefits (NEB). “The goal is to give them a measurement value to be considered in the decision-making calculus. It is assumed that soon; such factors will enter the general climate change economy, not unlike carbon in the past decade.”
In this context, the proposed research aims to develop a value-based framework that will support a Building Stock Model and subsequent Retrofit Models, documented in a web-tool platform. The framework has three main steps:A) Building Stock Model: Mapping of selected buildings of the program PAEIAPF in a GIS system. Documentation of the baseline energy consumption and embodied CO2-eq of the existing building.B) Retrofit Models: Involving a Whole Life Cycle Assessment (WLCA) and Non-Energy Benefits (resilience coefficient, health, productivity).C) Web Tool Platform: Application and toolset that allows for consistent documentation, environmental impact evaluation of existing building stock, and solution design in identifying energy reduction concepts.
Assessing the Level of Employees' Sustainability Awareness and its Effect on Sustainable Development Progression - A Case Study of Greater Karak Municipality/ Jordan
Authors: El-Shqeirat Sara
Published: April 2024

The current discourse on Sustainability Awareness (SA) is mainly focused on offering employees environmental training and education that aims to increase their participation in the organization's sustainable progress. Hence, overlooking the importance of the SA policy-making phase as well as the critical role designing SA programs plays in activating employees' efficient contribution to sustainability initiatives. Therefore, the significance of this research lies in offering an alternative model that integrates both processes of measuring and raising SA with the prospect of altering the organization's culture where sustainability value is created to motivate employees' engagement. In addition, this research will justify the failure of cases where environmental education, training, and SA programs did not positively affect employees' engagement nor did they benefit the organization's sustainable progress. This research presents organizations and decision-makers with a new approach to raising SA levels aiming to increase the potential for effective employment of the newly acquired knowledge. Hence, makes sustainable achievements more tangible. This model suggests the use of a qualitative approach to measuring employees' SA levels; a model that includes collecting data on employees'  insights, conceptions, sources of knowledge, and personal experiences of sustainability. This model would replace the commonly used quantitative approach to measure SA which is limited to analyzing data numerically to draw a statistical picture aiming to determine whether a pre-designed SA program should be implemented. Instead, managers could benefit from the data collected in the SA measuring process to identify the focus areas of the SA-raising program. Furthermore, such data would help organizations design SA programs that are specifically tailored to target a change in their employees' mindset and beliefs.
Carnivalesque Reading of Halide Edib Adivar’s The Clown and His Daughter
Authors:   Social Sciences University of Ankara, Yılmaz Victoria Bilge
Published: April 2024

Halide Edib Adıvar (1884-1964), prominent and revolutionary Turkish writer, wrote her novel The Clown and His Daughter in 1935 in English. With a colourful story of Rabia’s psychological, social, and physical development, Adıvar undertakes a meticulous re-examination of the social categories of her native land during an empire’s rapid moving into a state of a republic. This study will claim that Adıvar’s novel The Clown and His Daughter is a purely carnivalesque piece of work if analysed in terms of Bakhtin’s concept of the carnival. Mikhail Bakhtin rests the importance of the carnival sense of the world upon the transcending of every possible barrier between all living creatures in the universe. The theory of the carnival is infused with the atmosphere of freedom, excessiveness, challenge, rebirth, and bodily priorities. In a carnivalistic world, where a king can become a slave, an old woman can die while giving birth to a baby, or a man can unite with the whole world while consuming food. Bakhtin discusses such images under the term of the grotesque – an image of the bodies that constantly change from one form into another. Adıvar’s novel, in the same vein, focuses on the underlying unity between genders, communities, religions, races and human beings and animals. The setting and the characters in Adıvar’s novel can be recognised as carnivalistic because of their eccentricity, tendency to subvert social norms, and the urge to be able to feel the unity with the whole world. This study will conclude that Adıvar’s aim in writing this novel was to reveal the fundamental principle of a Turkish society – its social wealth that is indelibly marked by its endless varieties, differences, and fluctuating reality.
The admissibility of testimony in criminal proceedings: Modern approach and development vectors
Authors:   St. Petersburg State University, Novikov Sergei A.
Published: April 2024

In the article the most relevant aspects of the admissibility of the institution of testimony in modern Russian criminal proceedings are analyzed. The main part of the study includes four sections, the first of which criticizes legal definition of the very concept of the testimony of the victim, witness, suspect and accused, as information obtained solely as a result of their interrogation. It is proposed to consider the testimony of these participants as information obtained as a result of other investigative actions, not only such as confrontation, presentation for identification or verification of testimony on the spot, but also those that were not initially aimed at obtaining testimony: search, inspection, investigative experiment. The second section examines defects in the source of the interrogated's awareness that prevent the use of information from them in evidence: testimony based on rumors, guesses or an unnamed source, violating the secrecy of confession, attorney's or tax secrecy, reproducing unacceptable information or evaluating the falsity of other people's testimony by gestures or facial expressions. The third section indicates violations of the procedure for obtaining testimony, entailing their absolute inadmissibility: the use of torture, threats, the absence of participants provided for by law (defender, teacher, psychologist), leading questions. At the same time, it is proposed to distinguish between insignificant and avoidable violations that do not entail the inadmissibility of testimony. The fourth section examines the obstacles to the use in the conduct of the trial of those testimonies that were obtained earlier without violating the legal procedure. It is proposed to waive the ban on disclosing the previous testimony of the accused, obtained without the participation of a defender (when his participation was not legally mandatory), if they were not confirmed by the accused in court, as well as to soften the rules for the disclosure of testimony of non-present persons.
Crisis of the international legal system: concept, features, classification
Authors:   North-Western Branch of the Russian State University of Justice, Dorskaia Aleksandra A. , Dorskii Andrei Yu. ,   St. Petersburg State University, Petrovа Natal'ia D. ,   North-Western Branch of the Russian State University of Justice
Published: April 2024

The article performs a comprehensive analysis of the notion of the “crisis of the international legal system”. It has been demonstrated that the issue of crisis phenomena in international law holds a distinct position in the field of international legal science. Various approaches have been identified for studying this subject, encompassing both the theory of state and law as well as international law. Based on historical examples of the Westphalian, Versailles-Washington systems, as well as the UN system, such signs of a crisis of the international legal system are identified, as the degradation of the core principles that underpin the international legal system, the consistent disregard exhibited by the subjects of international law towards the principles and norms they previously established through consensus, the exclusion of key actors from the international legal system, the lack of a system of boundary agreements, the discrepancy between the evolving practical relations and the international legal regulations, the failure of subjects of international law to engage with international justice bodies during disputes, or the infrequent use of peaceful resolution methods for international conflicts, as well as attempts not to comply with the decision of the international court. The authors have coined the definition of a crisis of the international legal system. A classification of crises of the international legal system has been developed, containing examples from various stages of the development of international relations.
The effects of the public joint stock companies’ conversion on partners and creditors of the company "A comparative study between the Emirati and the Jordanian laws"
Authors:   Al Ain University, Madi Ramzi , Masn Muna ,   Muna Saeed Advocates & Legal Consultants
Published: April 2024

Purpose – This paper aims to investigates the concept of conversion and will discuss the effects of conversion on the partners and the company's creditors without discussing the effects of conversion for the converted company. Design/methodology/approach – This article compares two jurisdictions in middle east – United Arab Emirates, and Jordan. To find out how both jurisdictions have dealt with the effects of the public joint stock companies’ conversion on partners and creditors of the company. Findings – The article reached a set of findings, for example, it is not permissible for the transferred company to dissociate itself from the contracts that it had concluded before the transfer. The UAE legislator has done well when it explicitly stated that the rights of the partners or shareholders may not be violated towards the shareholders and creditors of the transferred company, holders of loan, bonds, or sukuk, and any interested party. Originality/value – Previous studies have been based on one jurisdiction, other than this study, which compared two jurisdictions in the middle east. Also, this article examined the recent commercial companies law issued in the United Arab Emirates. In addition, this article focused on one type of company, which is the public joint stock company.
3D Real Estate Cadastre: Risks Associated with Digital Innovation
Authors:   Russian State University of Justice, Boldyrev Vladimir A. , Svarchevsky Konstantin G. ,   Russian State University of Justice, Klepalova Yuliya I. ,   Russian State University of Justice
Published: April 2024

Statistical data on the statistics of the statistics of terms, relevant problems of the three-dimensional real estate cadastre, are applied and analyzed. It is noted that the creation of the public law company "Roskadastr" and the Unified Digital Platform "National Spatial Data System", on the basis of which information collected by a number of government agencies is integrated, is an incentive for conducting large-scale convergent research and a good reason for predicting the risks, associated with the formation of a three-dimensional real estate cadastre. Three-dimensional real estate cadastre Solution as a set of three-dimensional models in electronic form, reflecting the most significant physical (spatial) parameters of real estate objects. The factors stimulating and limiting the maintenance of a three-dimensional real estate cadastre are called. Determine the most significant negative consequences of maintaining a three-dimensional cadastre associated with the human cognitive sphere. For a three-dimensional real estate cadastre reflecting the parameters of the material world, the risks of information loss are not excessive assignment of the possibility of restoration of the possibility of restoration based on the requirement of the existing organism, which creates a voluminous registration and judicial system in a state of chaos or systemic uncertainty. It is concluded that conducting interdisciplinary research in this area and identifying risks as a result of technology assessment and social and humanitarian expertise is a matter of the future. At the same time, the most important parameters of regulatory regulation of the regulation of relations are the volumes available with the maintenance of a three-dimensional real estate cadastre, the volumes already today and should be reduced, at least, to establishing a ban on the inclusion in the public domain of a database sufficient to create three-dimensional models of real estate objects located in the operational management of state institutions, including government agencies.
The 2021 extreme rainfall in Gävle, Sweden: impacts on municipal welfare services and actions towards more resilient premises and operations
Authors: Glaas Erik , Hjerpe Mattias , Storbjörk Sofie
Published: April 2024

Climate-related risks, vulnerabilities, and impacts are increasing in cities, illustrated by precipitation-driven pluvial floods. Post-event analyses can aid in reducing urban flood risks, but knowledge gaps exist regarding how welfare services and premises are impacted and can be adapted. This study analyses an extreme precipitation-driven event generating extensive flooding in Gävle, Sweden, in 2021. The objective is to increase knowledge about how municipal welfare services are vulnerable to pluvial floods, and of appropriate actions towards improving the response capacity and building more resilient welfare premises and operations. The study shows that the Swedish weather warning system generally worked well, but the analysed property companies lacked strategies and equipment to evade flooding in their properties. Flood damages in 60 analysed buildings were generated by different causes, demonstrating the importance of contemplating the vulnerability of welfare buildings when conducting flood risk assessments. Although the flood event did not cause deaths or serious personal injuries, the study identified impacts on welfare service operations in both the short and long terms. The event increased learning on climate adaptation but did not trigger adaptive action. Identified keys for adaptation include prioritizing premises to protect, knowledge of flood protection equipment, insurance company requirements, and updated emergency plans.
Profissional Da Informação E Transformação Digital:estudo de caso - uX User Experience Design
Authors: Paletta Francisco Carlos
Published: April 2024

The article discusses the impact of digital transformation in the fields of information and librarianship, highlighting the new demands and challenges imposed toprofessionals in the field. It analyzes how the adoption of new digital technologies by information units can generate innovations in user services, through solutions such as artificial intelligence, virtual reality, personalization, and data analysis. It presents how the technology should be aligned with the needs of the users. The text also addresses the integration between the principles of User Experience Design and Information Science to develop user-centered services. The skills necessary for the information professional to work in the digital age are presented, such as technological mastery, digital information management, communication, teamwork, and continuous learning. It concludes that, with adequate training in technical, managerial, and behavioral skills, professionals can deal with the challenges of digital transformation in an ethical and strategic way.
De Las Piedras A La Nube: aprendizaje significativo y pedagogías digitales en el procesamiento de matrices litográficas habanera
Authors: Hernández Quintana Ania R.
Published: April 2024

The activities associated with the Litokingospedagogical project are referred to for the treatment of almost two thousand lithographic matrices from the 19th and 20th centuries, stored in the Havana Graphic Workshop. Their characterization as ephemeral documents and the relevance of the communicative landscapes’methodology for the analysis of the corpusare justified. The budgets used for the meaningful learning methodology with first-year students of the Information Science day course at the University of Havana are presented. The strengths of memorable learning of documentary techniques and their link with communication strategies that allow generating positive discourses on the importance of humanistic data, teamwork, the discovery of traditions, as well as content management for different digitalsocial networks are evident. The importance of open access digital infrastructures for executing pedagogical models in the global South is demonstrated.
THE ECLIPSING PHENOMENON IN CELEBRITY ENDORSEMENT, EMOTIONAL RESPONSE, PURCHASE INTENTION BASED ON THE STIMULUS-ORGANISM-RESPONSE THEORY
Authors:   School of Business and Management, Ciputra University, Indonesia, Sumaji Yoseva Maria Pujirahayu , Kaihatu Thomas Stefanus ,   School of Business and Management, Ciputra University, Indonesia, Sutanto Verrell ,   School of Business and Management, Ciputra University, Indonesia, Toreh Fabio Ricardo ,   School of Business and Management, Ciputra University, Indonesia, Immanuel Dewi Mustikasari ,   School of Business and Management, Ciputra University, Indonesia, Azizurrohman Muhammad ,   Southern Taiwan University of Science and Technology, Taiwan
Published: April 2024

An advertisement must pay attention to the concepts and strategies in advertising because the use of this endorser can be a double-edged knife for the brand. In the vampire effect phenomenon, celebrity endorsers can potentially overshadow the brand so that the audience focuses only on the celebrity, not the brand. Specifically, the phenomenon of a brand that the celebrity endorser overshadows is called high eclipsing an endorsement, and vice versa for the phenomenon of low eclipsing. This research was conducted to develop a framework that discusses the eclipsing phenomenon in celebrity endorsement in the context of stimulus-organism-response (SOR) theory. The participants in this study were undergraduate students in a department at a well-known university in Surabaya. The characteristics of the Participants are domiciled in Surabaya and are between 18-24 years old. Through this study, we can find out how consumers' emotional response is formed when faced with high- and low-eclipsing advertisement stimuli. In addition, this study will also discuss how the differences in purchase intentions are formed from these two different eclipsing endorsement stimuli. The research indicates a significant positive effect between exposure to advertising content featuring both high-eclipsing (HE) and low-eclipsing (LE) celebrity endorsements and emotional response (EM). It implies that leveraging celebrities in advertisements, regardless of their eclipsing status, can evoke a heightened emotional response from the audience. The study suggests a noteworthy association between exposure to advertising content containing celebrity endorsements (CE) and increased purchase intention (PI). Consumers are more likely to desire to purchase a product or service when it is endorsed by a celebrity, indicating the potential effectiveness of this marketing strategy.
THE ROLE OF EXPERIENTIAL MARKETING TOWARDS PURCHASE INTENTION IN VERTICAL BUILDING PROPERTY MEDIATED BY BRAND IMAGE AND BRAND AWARENESS
Authors:   Ciputra Property, Raditya Andreas , Harianto Eric ,   Ciputra University, Nahar Faiza Husnayeni ,   Economic Departement, Universidad de Granada, Spain
Published: April 2024

The Covid-19 pandemic has caused various behavioral changes in society, especially in business. People's consumption behavior has shifted to the consumption of daily necessities products, so that sales in property have decreased. This study aims to examine the effect of Experiential Marketing on Purchase Intention at the Ciputra International Jakarta Superblock Project. This research uses a quantitative design using SEM-PLS analysis. The population in this study is sales candy data obtained through Instagram booster ads in the Jakarta area of as many as 334 people, which is also determined by the number of saturated samples. The results showed that experiential marketing variables have a significant influence on brand image and brand awareness. Brand image and brand awareness variables have a significant and positive effect on Purchase Intention. In addition, the results of the mediation of Experiential Marketing variables mediated by Brand Image and Brand Awareness variables have a positive and significant effect on Purchase Intention. The implication of this research is that experiential marketing activities (sense, feel, think, act, and relate) are needed to improve brand image and brand awareness so that they can help increase consumer purchase intention in the vertical building property industry.
INNOVATION CAPABILITY OF LEARNING ORIENTATION MEDIATORS ON THE PERFORMANCE OF TOURISM INDUSTRY MSMES
Authors:   Universitas Dhyana Pura, Indonesia, Santoso R Tri Priyono Budi , Fettry Sylvia ,   Universitas Katolik Parahyangan Bandung, Indonesia, Hermawati Adya ,   Universitas Widyagama Malang, Indonesia, Bahri Syamsul ,   Universitas Widyagama Malang, Indonesia, Fatmawati Endang ,   Universitas Diponegoro Semarang, Indonesia, Ali Shujahat ,   Mirpur University of Science and Technology, Pakistan
Published: April 2024

The aim of this research is to prove the influence of learning orientation on the innovation ability and performance of MSMEs. Innovation ability mediates the influence of learning orientation on the performance of tourism MSMEs in Greater Malang. A quantitative approach was used with 100 tourism MSME owners in Malang Raya, East Java, Indonesia. Using Structural Equation Modeling (SEM) analysis, it shows that learning orientation has an influence on innovation ability and MSME performance and innovation ability has an influence on MSME performance and innovation ability is able to mediate the relationship between learning orientation and the performance of tourism MSMEs in Malang Raya. Based on the research findings, suggestions are put forward that tourism MSME actors in Greater Malang must adapt to environmental changes so that future researchers can study the business environment and market orientation to improve the performance of tourism MSMEs in Greater Malang.