bluuebunny/crossref_metadata_2025 huggingface dataset:
Improved cycling stability of LiCoO2 at 4.5 V via surface modification of cathode plates with conductive LLTO
Authors: Song Shipai , Peng Xiang , Huang Kai , Zhang Hao , Wu Fang , Xiang Yong , Zhang Xiaokun
Published: February 2020

The stability issue of LiCoO 2 cycled at high voltages is one of the burning questions for the development of lithium ion batteries with high energy density and long cycling life. Although it is effective to improve the cycling performance of LiCoO 2 via coating individual LiCoO 2 particles with another metal oxides or fluorides, the rate capacity is generally compromised because the typical coating materials are poor conductors. Herein, amorphous Li 0.33 La 0.56 TiO 3 , one of the most successful solid electrolytes, was directly deposited on the surface of made-up LiCoO 2 cathode plates through magnetron sputtering. Not only the inherent conductive network in the made-up LiCoO 2 cathode plates was retained, but also the Li + transport in bulk and across the cathode-electrolyte interface was enhanced. In addition, the surface chemical analysis of the cycled LiCoO 2 cathode plates suggests that most of the stability issues can be addressed via the deposition of amorphous Li 0.33 La 0.56 TiO 3 . With an optimized deposition time, the LiCoO 2 cathode plates modified by Li 0.33 La 0.56 TiO 3 performed a steady reversible capacity of 150 mAh/g at 0.2 C with the cut-off voltage from 2.75 to 4.5 V vs. Li + /Li, and an 84.6% capacity gain at 5 C comparing with the pristine one.
Simulated patient and role play methodologies for communication skills and empathy training of undergraduate medical students
Authors: Bagacean Cristina , Cousin Ianis , Ubertini Anne-Helene , Idrissi Mohamed El Yacoubi El , Bordron Anne , Mercadie Lolita , Garcia Leonor Canales , Ianotto Jean-Christophe , De Vries Philine , Berthou Christian
Published: February 2020

Background

Verbal and non-verbal communication, as well as empathy are central to patient-doctor interactions and have been associated with patients’ satisfaction. Non-verbal communication tends to override verbal messages. The aim of this study was to analyze how medical students use verbal and non-verbal communication using two different educational approaches, student role play (SRP) and actor simulated patient (ASP), and whether the non-verbal behaviour is different in the two different poses.

Methods

Three raters evaluated 20 students playing the doctor role, 10 in the SRP group and 10 in the ASP group. The videos were analyzed with the Calgary-Cambridge Referenced Observation Guide (CCG) and, for a more accurate evaluation of non-verbal communication, we also evaluated signs of nervousness, and posture. Empathy was rated with the CARE questionnaire. Independent Mann Whitney U tests and Qhi square tests were performed for statistical analysis.

Results

From the 6 main tasks of the CCG score, we obtained higher scores in the ASP group for the task ‘Gathering information’ (p=0.0008). Concerning the 17 descriptors of the CCG, the ASP group obtained significantly better scores for ‘Exploration of the patients’ problems to discover the biomedical perspective’ (p=0.007), ‘Exploration of the patients’ problems to discover background information and context’ (p=0.0004) and for ‘Closing the session – Forward planning’ (p=0.02). With respect to non-verbal behaviour items, nervousness was significantly higher in the ASP group compared to the SRP group (p<0.0001). Concerning empathy, no differences were found between the SRP and ASP groups.

Conclusions

Medical students displayed differentiated verbal and non-verbal communication behaviour during the two communication skills training methodologies. These results show that both methodologies have certain advantages and that more explicit non-verbal communication training might be necessary in order to raise students’ awareness for this type of communication and increase doctor-patient interaction effectiveness.
Prognostic death factors in SHLH children with MODS receiving CRRT: a multicenter prospective nested case-control study
Authors: Cui Yun , Shi Jingyi , Shan Yijun , Wang Chunxia , Ren Yuqian , Lu Guoping , Yan Gangfeng , Zhu Xiaodong , Zhu Yueniu , Wang Ying , Ren Hong , Zhang Yucai
Published: February 2020

Background: Multiple organ dysfunction syndrome (MODS) with secondary hemophagocytic lymphohistiocytosis (SHLH) causes significant mortality, while continuous renal replacement therapy (CRRT) is commonly conducted. The objective is to identify the predictor factors associated with poor outcomes in pediatric patients with SHLH -associated MODS who received CRRT. Methods: A multicenter prospective nested case-control study in four PICUs of tertiary university children’s hospital in Shanghai from September 2013 to August 2018.We prospectively studied 52 SHLH-associated MODS pediatric patients receiving CRRT. Results: Overall PICU mortality rate was 46.15%(24/52). Less respiratory (28.6% vs. 87.5%, P <0.001) or cardiovascular dysfunction (25% vs. 83.3%, P <0.001) caused in survivors at CRRT initiation, as well as reduced demands of mechanical ventilation and vasoactive agents (28.6% vs. 87.5%,17.9 % vs. 66.7 %, both P <0.001). Non-survivors had higher levels of serum lactate dehydrogenase (1404.5 (713.25, 2793) vs. 982.7 (692, 1461) (U/L), P = 0.037), lactic acid (1.9 (1.3, 4.53) (mmol/L) vs. 1.65 (0.8, 2.45) , P=0.034), triglyceride (2.88 (1.94, 5.08) (mmol/L) vs. 2.41 (1.63, 3.32), P=0.032) and IL-6 (28.66 (17.77, 113.63) (pg/ml) vs.0.98 (0.1, 4.63) P=0.000). More than 3 organ dysfunction (Odd ratio [ OR ] : 3.464; 95% confidence interval [ CI ] [1.018-11.788], P = 0.047), and the serum IL-6 level higher than 13.12 pg/mL ( OR :1.388; 95% CI [1.058-1.821], P = 0.018 ) were two independent risk factors for mortality. Conclusions: The number of organ dysfunction and IL-6 levels at CRRT initiation are the independent risk factors for mortality in SHLH-associated MODS patients.
Recommendations for fluid management of adults with sepsis in sub-Saharan Africa: A systematic review of guidelines
Authors: Silberberg Benjamin Peter , Aston Stephen , Boztepe Selda , Rylance Jamie
Published: February 2020

Background Sepsis guidelines are widely used in High Income Countries and intravenous fluids are an important supportive treatment modality. However, fluids have been harmful in intervention trials in Low-Income Countries, most notably in sub-Saharan Africa. We assessed the relevance, quality and applicability of available guidelines for the fluid management of adult patients with sepsis in this region. Methods We identified sepsis guidelines by systematic review with broad search terms, duplicate screening and data extraction. We included peer-reviewed publications with explicit relevance to sepsis and fluid therapy. We excluded those designed for specific medical conditions, for limited geographic locations, or for non-adult populations. We used the AGREE II tool to assess the quality of guideline development, performed a narrative synthesis and using theoretical case scenarios to assess practical applicability to everyday clinical practice in resource-constrained settings. Results Published sepsis guidelines are heterogeneous in sepsis definition and in quality: 8/10 guidelines had significant deficits in applicability, particularly with reference to resource considerations in low-income settings. Indications for intravenous fluid were: hypotension (8/10); clinical markers of hypoperfusion (6/10); lactataemia (3/10). Crystalloids were overwhelmingly recommended (9/10). Suggested volumes varied; 5/10 explicitly recommended “fluid challenges” with reassessment, totalling between 1L and 4L during initial resuscitation. Fluid balance, including later de-escalation of therapy was not specifically described in any. Norepinephrine was the preferred initial vasopressor (5/10), specifically targeted to MAP >65mmHg (3/10), with higher values suggested in pre-existing hypertension (1/10). Recommendations for guidelines were almost universally derived from evidence in High Income Countries. None of the guidelines suggested any refinement for patients with malnutrition. Conclusions Widely used international guidelines contain disparate recommendations on intravenous fluid use, lack specificity and are largely unattainable in Low-Income Countries given available resources. A relative lack of high-quality evidence from sub-Saharan Africa increases reliance on recommendations which may not be relevant or implementable.
Enhanced Biometric Recognition for Secure Authentication using Iris Preprocessing and Hyper Elliptic Curve Cryptography
Authors: Rajasekar Vani , J Premalatha , K Sathya
Published: February 2020

Biometrics combined with cryptography can be employed to solve the conceptual and factual identity frauds in digital authentication. Biometric traits are proven to provide enhanced security for detecting crimes because of its interesting features such as accuracy, stability and uniqueness. Although diverse techniques have been raised to address this objective, limitations such as higher computational time, minimal accuracy and maximum recognition time remain. To overcome these challenges an enhanced iris recognition approach has been proposed based on Hyper Elliptic Curve Cryptography (HECC). The proposed study uses 2D Gabor filter approach for perfect feature extraction in iris preprocessing. Light weight cryptographic scheme called HECC was employed to encrypt the iris template to avoid intentional attack by the intruders. The benchmark CASIA Iris V-4 and IITD Iris datasets were used in the proposed approach for experimental analysis. The result analysis witnessed that the prime objective of the research such as lesser false acceptance rate, lesser false rejection rate, maximum accuracy of 99.74%, maximum true acceptance rate of 100%, and minimal recognition time of 3 seconds has been achieved. Also it has been identified that the proposed study outperforms other existing well known techniques.
Similar outcomes for intramedullary nail versus locking plate in treating proximal humerus fractures: a retrospective study
Authors: FENG GAO , wang xiu-hui , xia sheng-li , zhou xiao-xiao , fu bei-gang , yi cun-guo , wang ming-hui
Published: February 2020

Objective The aim of this study was to compare the clinical and radiographic outcomes and complications following locking plate versus intramedullary nail fixation of 2- and 3-part proximal humerus fractures. Methods A total of 97 patients (47, nail group; 50, plate group) were included in this retrospective study. The patients were treated either with an intramedullary nail or a locking plate. The length of the surgical incision, operative time, healing time, Constant-Murley score, and postoperative complications were compared between groups. Results The average length of the incision, operative time of intramedullary nail group were significantly less than locking plate group (P<0.05). There were no significant differences in the average fracture union time, Constant-Murley functional score, postoperative neck-shaft angle and neck-shaft angle a year after surgery (P>0.05). Postoperative complications in the plate group included delayed union (n=2), screw cutout (n=1), varus malunion (n=3), displacement of the greater tubercle (n=1), and subacromial impingement syndrome (n=1). Complications in the nail group included delayed union (n=1), screw cutout (n=3), displacement of the greater tubercle (n=4), and subacromial impingement syndrome (n=3); varus malunion was not observed. Conclusion Both the nail and locking plate were effective and had similar outcomes in patients with 2- or 3-part proximal humerus fractures. For valgus-type fractures, the plate had an advantage over the nail; for varus-type, the nail was a better option.
Does the current Scope of nutrition labelling provided in the Saudi markets cope with the increasing trend of chronic disease?
Authors: Jr Hoda , AlMughthem Amal , Bawazir Amen A
Published: February 2020

Background: With increased demand for prepackaged food, the nutrient content of those products has increased especially fat, sugar, and sodium. We aimed to assess the compliance of nutritional labeling and to analyze the stated nutritional components as presented on prepackaged food products in Saudi market. Methods: A total of 1153 foods were randomly sampled from fourteen stores. Nutritional information was taken from nutrient declarations present on food labels and assessed through a comparison of mean levels and assess compliance with Saudi Food and Drug Authority regulations. Results: Overall, of the total number of products surveyed, 88% displayed nutritional facts, while 12% did not. Of the total products that had nutritional facts, only 38% met SFDA requirements while 97% disclosed the four key nutritional elements (energy, carbohydrate, protein and fat). In total, almost one third of the products had a high fat content, 40% were high in sugar and 20% were high in Sodium. We found also, 20% listed hydrogenated fat in their ingredient information, 90% of which was fully hydrogenated, while 10% was partially hydrogenated. Conclusion: There was a high percentage of products that displayed nutritional facts, but only a small percentage complied with SFDA's recent regulations. Food reformulation could have an extraordinary potential to overcome the increase in nutrition-related chronic disease in Saudi Arabia, and the information acquired from this paper provides an overview of thinking about the food supply as a major source needed for a national intervention.
Risk Factors for Prolonged Hospital Stay and In-Hospital Mortality in Hip Fracture Patients Aged Over 65 Years: A Composite Endpoint Analysis
Authors: Marín Jorge Salvador , Martínez Francisco Javier Ferrández , Ripoll Jose Miguel Seguí , Rico José Antoio Quesada , Beltrán Domingo Orozco , Munuera María Concepción Carratalá , López José Fernando Martínez , Campos Juan Carlos Marzo
Published: February 2020

Objectives : This study aimed to determine the risk factors that increase the risk of in-hospital mortality and/or prolonged hospital stay in hip fracture patients aged over 65 years. Methods : We conducted a retrospective study of patients aged over 65 years who underwent hip fracture surgery in the period from January 2015 to December 2017. Our analysis included 54 variables related to medical, psychological, functional and laboratory comorbidities present at admission; treatment, complications and laboratory follow-up during the hospital stay; and functional status and destination on discharge. We performed a bivariate analysis and a multivariate analysis with a composite endpoint combining in-hospital mortality and hospital stay lasting more than 10 days. Results : We included 360 patients with an average age of 84 years. Women accounted for 75% of the sample, and 53.5% of all patients had a pertrochanteric fracture. The mean number of comorbidities per patient was 2.72, and the most common comorbidities were high blood pressure, dementia and diabetes. The rate of in-hospital mortality was 3.6% (n 13) and the mean length of hospital stay was 8.48 days, with 16.4% of patients staying in hospital for more than 10 days. Medical complications, lower hemoglobin on admission, high blood pressure, obesity and Parkinson’s disease were significantly associated with our endpoint in the multivariate analysis Conclusions : Patients who suffer medical complications during hospitalization, and those with lower hemoglobin on admission, high blood pressure, obesity or Parkinson’s disease, have an increased risk of in-hospital mortality or prolonged hospital stay
High Pain Catastrophizing Scale predicts lower patient-reported outcome measures in the foot and ankle patient
Authors: Veljkovic Andrea , Gagne Oliver , Abuhantash Monther , Younger Alastair , Symes Michael , Abbas Kaniza Zahra , Penner Murray J. , Wing Kevin J. , Syed Khaled A. , Lau Johnny
Published: February 2020

Background: A patient’s healthcare experience can be modulated by their understanding of their pre-operative disability along with their overall coping strategy. It is hypothesized that patient’s catastrophization and expectation on what they deem to be a successful surgery can affect their outcome. Methods: This current study prospectively assessed a consecutive cohort of patients undergoing foot and ankle reconstruction to describe the relationship between Pain Catastrophizing Scale (PCS) and patient-reported outcomes: SF-12 & FAOS. The PCS has a total score and three subcategories which are rumination, helplessness and magnification. Results: Forty-six patients were found to be eligible in the study with an average age of 54.7±14.4 years-old, a majority female (65%), a minority employed at the pre-operative visit (41%) and with an average BMI of 26.2±5.56. Looking at the FAOS Pain domain, it correlated significantly with the PCS Rumination and Helplessness subcategories. The FAOS Activity of Daily Living domain showed significant correlation with the PCS Rumination and Helplessness subcategories. The FAOS Quality of life domain was also statistically significant for the PCS Rumination and Helplessness subcategories. We found that the mental domain of the SF-12 had a statistically significant effect when compared to the Rumination (p=0.01) and Helplessness (p=0.001) subcategories.Conclusion: This study showed a significant association between an increase preoperative PCS and a worse one-year outcome looking at the FAOS domains. As such, in elective foot and ankle surgery, catastrophization should be screened for and potentially modulated pre-operatively to improve patient operative outcomes.
Cost-Effectiveness Analysis of Advanced Radiotherapy Techniques for Post-Mastectomy Breast Cancer Patients
Authors: Xie Yibo , Guo Beibei , Zhang Rui
Published: February 2020

Background: Prior cost-effectiveness studies of post-mastectomy radiotherapy (PMRT) only compared conventional radiotherapy versus no radiotherapy and only considered tumor control. The goal of this study was to perform cost-effectiveness analyses of standard of care (SOC) and advanced PMRT techniques including intensity-modulated radiotherapy (IMRT), standard volumetric modulated arc therapy (STD-VMAT), non-coplanar VMAT (NC-VMAT), multiple arc VMAT (MA-VMAT), Tomotherapy (TOMO), mixed beam therapy (MIXED), and intensity-modulated proton therapy (IMPT).Methods: Using a Markov model, we estimated the cost-effectiveness of various techniques over 15 years. A cohort of women (55-year-old) was simulated in the model, and radiogenic side effects were considered. Transition probabilities, utilities, and costs for each health state were obtained from literature and Medicare data. Model outcomes include quality-adjusted life-years (QALYs) and incremental cost-effectiveness ratio (ICER), and SOC was used as the reference.Results: For the patient cohort, IMRT is the most cost-effective technique with an ICER value of 27,310 $/QALY, and IMPT has the highest ICER of 74,564 $/QALY. One-way analysis shows that the probability of cardiac toxicity has the most significant impact on the model outcomes. The probability sensitivity analyses show that all advanced PMRT techniques are more cost-effective than SOC at a willingness-to-pay (WTP) threshold of 100,000 $/QALY, while almost none of the advanced techniques is more cost-effective than SOC at a WTP threshold of $50,000/QALY.Conclusion: Advanced PMRT techniques are more cost-effective for breast cancer patients at a WTP threshold of 100,000 $/QALY, and IMRT might be the most cost-effective option for PMRT patients.
Added value of SPECT-CT imaging in the diagnosis of unilateral active mandibular hypercondylia in adult: A Case Report.
Authors: FOKOUE Fabrice , Mselmi Sanae El , Abaouz Nadia , Ismaili Nadia Alaoui
Published: February 2020

Mandibular hypercondylia is a rare and autonomous bone disease due to the excessive growth of the condylar cartilage. The radiological assessment following the clinical examination remains essential to the diagnostic orientation. Planar bone scintigraphy has been frequently used to assess the active or inactive nature of this situation. We report here the case of a patient whose diagnosis of active mandibular hypercondylia was retained due to the complement with SPECT / CT imaging, the planar bone scintigraphy being negative.
Effects and safety of platelet-rich plasma (PRP) and hyaluronic acid (HA), alone and in combination, in the treatment of knee osteoarthritis: A systematic review and meta-analysis.
Authors: Zhao Jinlong , Huang Hetao , Liang Guihong , Zeng Ling-feng , Yang Weiyi , Liu Jun
Published: February 2020

Background Studies have shown that the combined application of hyaluronic acid (HA) and platelet-rich plasma (PRP) can repair degenerated cartilage and delay the progression of knee osteoarthritis (KOA). The purpose of this study was to explore the efficacy and safety of PRP combined with HA in the treatment of KOA compared with intra-articular injection of PRP or HA alone. Methods The PubMed, Cochrane Library, EMBASE and China National Knowledge Infrastructure (CNKI) databases were searched from inception to December 2019. Two orthopaedic surgeons conducted the literature retrieval and extracted the data. Outcome indicators include the Western Ontario and McMaster Universities Arthritis Index (WOMAC), the Lequesne Index, the visual analogue scale (VAS) for pain, and adverse events (AEs). Results Seven studies (5 randomized controlled trials, 2 cohort studies) with a total of 941 patients were included. In the VAS comparison after 6 months of follow-up, PRP combined with HA was more likely to reduce knee pain than PRP alone (standardized mean difference (SMD): -0.31; 95% confidence interval (CI): -0.55 to -0.06; P=0.01 <0.05). PRP combined with HA for KOA achieved better improvement in WOMAC Function Score (SMD: -0.32; 95% CI: -0.54 to -0.10) and WOMAC Total Score (SMD: -0.42; 95% CI: -0.67 to -0.17) at the 12-month follow-up than the application of PRP alone. In a comparison of Lequesne Index scores at a 6-month follow-up, PRP combined with HA improved knee pain scores more than PRP alone (SMD: -0.42; 95% CI: -0.67 to -0.17). In terms of AEs, PRP combined with HA was not significantly different from PRP or HA alone (P>0.05). Conclusions Compared with intra-articular injection of PRP alone, PRP combined with HA can improve WOMAC Function Scores, WOMAC Total Score, 6-month follow-up VAS ratings, and Lequesne Index scores. However, in terms of the incidence of AEs, PRP combined with HA was not significantly different from PRP or HA alone.
Validation and reliability of a simplified food frequency questionnaire: A cross sectional study among physical health examination adults in southwest region of China
Authors: Cheng Zhengyan , Shuai Ping , Qiao Qichuan , Li Tingxin
Published: February 2020

Background In China, many people are apt to participate in regular physical examination as a precaution. Some simplified food frequency questionnaire have been designed and used. However, the effectiveness of questionnaire is absent. This study was conducted to examine the reliability and validity of simplified food frequency questionnaire (SFFQ) used among physical examination adults in southwest region of China. Methods This study was a cross sectional study among physical health examination adults in Southwest region of China. A total of 239 participants aged 20-65 were conducted during February to June in 2019. The performance of the SFFQ was evaluated by the mean of three-day 24-hour dietary recalls (3R24). The relative validity and agreement was assessed by the Pearson`s correlation and intra-class correlation coefficients(ICC) respectively. Results The median energy-adjusted ICC of food groups between SFFQ2 and SFFQ1 was 0.59 (range: 0.49-0.73) and the ICC of nutrients was 0.47(range: 0.39-0.76). The Pearson correlation showed the validity between the SFFQ1 and 3R24, which ranged from -0.086 to 0.93 for food and and 0.21 to 0.71 for nutritions, respectively. Energy-adjustment slightly increased the correlation coefficients. Conclusions The reliability and validity of the SFFQ was acceptable. It could be an appropriate dietary assessment tool for future epidemiological studies in physical health examination adults among Chinese in southwest China.
“Dobosh Case”: the Biggest Failure of ZCH OUN Security Services in Resistance to KGB Apparatus
Authors: Antoniuk Yaroslav M.
Published: February 2020

The article carries out a research on circumstances of the arrest of Yaroslav Dobosh, who was a courier of the OUN Foreign cells (hereafter – ZCh), by the KGB authorities, using the documents of the Branch State Archive of the Security Service of Ukraine as its basis. It was indicated that the mentioned arrest had a significant influence on the dissident movement in Soviet Ukraine. It was proven that the KGB bodies used the “Dobosh case” to launch their massive repressions against the anti-Soviet intelligentsia (“Block” operation), and also to undermine the OUN’s credibility among the Ukrainian diaspora environment in the Western countries. The consequences of that event were reflected in the development of the entire Ukrainian national liberation movement of the 1970s. After analyzing the personality of Yaroslav Dobosh, we discovered that he had been raised in a nationally conscious and religious environment of the Ukrainian diaspora of Belgium. From his early years he joined the Ukrainian Youth Association and agreed to conduct a dangerous mission in Ukraine solely because of his convictions. During that period the OUN Foreign cells had been trying to establish connections with the dissident movement in Ukraine and support it. The tourism was one of the most effective ways of bringing couriers to the Soviet Union. The KGB bodies regularly arrested those couriers. Nevertheless, there was no better communication means between the ZCh OUN and the dissidents. Yaroslav Dobosh had walked into a trap, previously prepared and set by the KGB employees, that was a reason why he failed to spot any danger and was arrested. During interrogations, he revealed his connections with the dissidents in Kyiv and Lviv – Zinovia Franko, Ivan Svitlychnyi, Leonid Selezenko and Stephania Gulyk. In addition to that, he agreed to publicly make a repentance. After that Yaroslav Dobosh was allowed to return home. In Belgium he immediately abandoned his testimonies and claimed that he had been forced and pressed to come out with a speech. However, those statements were of no importance. The KGB organs actively used Dobosh image as a proof of the dissidents cooperation with the Western intelligence services. Emphasizing the failure of the ZCh OUN operation, they launched a campaign to combat “Ukrainian bourgeois nationalism” in Western Ukraine and made provocations to intensify disputes in the anti-Soviet camps of the Ukrainian diaspora.
Keywords: dissidents, KGB, ZCh OUN, UYA, Belgium, “Dobosh case”, repressions, ”Block” operation, Kyiv, Lviv, Soviet, diaspora.
Robust Independent Validation of Experiment and Theory: Rivet version 3
Authors: Bierlich Christian , Buckley Andy , Butterworth Jonathan , Christensen Christian Holm , Corpe Louie , Grellscheid David , Grosse-Oetringhaus Jan Fiete , Gutschow Christian , Karczmarczyk Przemyslaw , Klein Jochen , Lönnblad Leif , Pollard Christopher Samuel , Richardson Peter , Schulz Holger , Siegert Frank
Published: February 2020

First released in 2010, the Rivet library forms an important repository for
analysis code, facilitating comparisons between measurements of the final
state in particle collisions and theoretical calculations of those final
states. We give an overview of Rivet's current design and implementation, its
uptake for analysis preservation and physics results, and summarise recent
developments including propagation of MC systematic-uncertainty weights,
heavy-ion and ep physics, and systems for detector emulation. In addition,
we provide a short user guide that supplements and updates the Rivet user
manual.
GENOGRAMA MANUAL VERSUS VIRTUAL: COMPARABILIDADE DA APLICABILIDADE DOS MÉTODOS
Authors: Ivastcheschen Taís , Santos Rulliane Aparecida dos , Sicorra Thayne Da Rosa , Silva Junior Manoelito Ferreira
Published: February 2020

Objetivo: descrever a aplicabilidade do genograma como ferramenta para gestão da clínica e comparar a aplicação em modo manual e virtual. Método: estudo qualitativo, descritivo, do tipo relato de experiência, realizado por acadêmicas de enfermagem, no período de maio a junho de 2019. Dados coletados por meio de entrevista semi-estruturada com a paciente em visita domiciliar e após elaboração do genograma de maneira manual e na versão virtual. Resultados: observou-se na construção teórica do trabalho que poucos profissionais da saúde sabem como usar esta ferramenta e como ela pode agregar a prática diária. Verificou-se a importância do genograma na aproximação do profissional com o paciente, organização do processo de trabalho e leitura rápida e abrangente da organização familiar.  Com o genograma manual foi necessário consulta dos símbolos e seus significados em materiais de apoio, para a versão virtual foi necessário um cadastro, leitura breve do manual de instruções e então preenchimento dos campos de informação no site. No geral o genograma permite combinar informações de determinada família, compreender o individuo no seu contexto, localizar o problema de saúde, explorar e aconselhar situações problema, possui não só valor diagnóstico, mas também terapêutico.  Conclusão: a aplicação do genograma foi uma experiência enriquecedora na prática acadêmica, demonstrou que esta ferramenta acrescentada à gestão da clinica, enriquece o processo de trabalho de profissionais da saúde, proporciona melhorias no atendimento aos usuários e facilita a organização de ações, entre o genograma manual e o virtual, observou-se a melhor desenvoltura da versão online por ser mais rápida e padronizada, no entanto, depende de computador e internet.
THE ACTIVITY OF THE HIGHER OFFICIALS OF SUBJECTS OF THE RUSSIAN FEDERATION IN THE SYSTEM OF STRATEGIC PLANNING
Authors: Miroscnikov S. N.
Published: February 2020

Sustainable and balanced socio-economic development of the constituent entities of the Russian Federation cannot be carried out without planned management. However, the introduction of strategic planning systems faces a number of problems, the most important of which can be considered the shortcomings of goal-setting and forecasting of the socio-economic situation at the regional level, which has so far received insufficient attention. Orientation in the subjects of the Federation only on national goals without the possibility of using Federal management tools reduces the effectiveness of public authorities, does not allow to sufficiently take into account the specifics of regional development and social needs of the population. The analysis shows the possibility of applying the sustainable development Goals up to 2030, developed and recommended by the United Nations in 2015, which correlate with the indicators of assessing the effectiveness of senior officials of the subjects of the Federation established by the decree of the President of Russia. No less important is the problem of ensuring the implementation of strategic plans. The choice of approaches, tools and mechanisms for the implementation of strategies, programs and projects of regional development should be carried out in the context of the development of strategic planning practices, to improve the efficiency of public administration on the basis of the project approach, the expansion of the use of public-private partnership, the promotion of small and medium-sized businesses.
ALTERNATIVE FORMS OF EMPLOYMENT AND THE PROBLEM THEIR LEGAL REGULATION
Authors: Kuzmina Yu. N.
Published: February 2020

For the Russian labor market, the problem of legal regulation of alternative forms of employment is quite acute. Non-standard forms of employment existed before, but today, thanks to the development of Internet technologies and mobile communications, they have become widespread. There is a significant increase in non-standard employment, which is associated with increased competition, unemployment, the development of new technologies, and the growth of demographic groups that prefer flexible employment (students, people of creative professions). Therefore, a detailed study of this sphere, ways of taking into account the forms and types of such employment, issues of providing employees with proper rights and guarantees is required. The author analyzed the innovations in the legislation in the sphere of control over the self-employed. On this basis, some of the disadvantages and advantages of the mechanisms of legal regulation of alternatively employed workers have been identified. Identified the main reasons that impede the control of this group of employed citizens.
Formation of Carbon-Carbon Bonds Mediated by Hypervalent Iodine Reagents Under Metal-free Conditions
Authors: Li Xiaoxian , Liu Tongxing , Zhang Beibei , Zhang Dongke , Shi Haofeng , Yu Zhenyang , Tao Shanqing , Du Yunfei
Published: February 2020

During the past several decades, hypervalent iodine reagents have been widely
used in various organic transformations. Specifically, these exclusive classes of reagents
have been extensively used for the construction of carbon-carbon bonds. This review aims
to cover all the reactions involving the construction of carbon-carbon bonds mediated by
hypervalent iodine reagents, providing references and highlights for synthetic chemists
who are interested in hypervalent iodine chemistry.
Removal of Targeted Pharmaceuticals and Personal Care Products from Wastewater Treatment Plants using QSAR Model
Authors: Madhura Lavanya , Singh Shalini , Kanchi Suvardhan , Sabela Myalowenkosi I. , Bisetty Krishna , Inamuddin
Published: February 2020

Background:

Because of their intrinsic ability to induce physiological effects in humans
at low doses, pharmaceuticals and personal care products (PPCPs) are a unique group of emerging
environmental pollutants. A number of studies have confirmed the occurrence of different PPCPs in
the environment, which raises concerns about possible adverse effects on humans and wildlife. The
removal of PPCPs from wastewaters has become a major activity to reduce pollution due to their adverse
effects on humans and aquatic ecosystems.

Methods:

This study aimed to design a Quantitative Structure Activity Relationship (QSAR) model
for the removal of 57 PPCPs from wastewater treatment plants (WWTPs) of historical data obtained
from plants located in South Korea. The target compounds of PPCPs were optimised geometrically
using a Forcite-Geometry code, assembled in Material Studio 2016.

Results:

The removal efficiency of PPCPs is dependent on several preliminary molecular descriptors
including rotatable bonds (RBs), hydrogen bond donor (HBD), total molecular mass (TMM), binding
energy (BE), atom count (AC), element count (EC), total energy (TE), total dipole (TD), highest occupied
molecular orbital (HOMO) and lowest unoccupied molecular orbital (LUMO). A Genetic
Function Approximation (GFA) method was adopted to perform regression analysis and create correlation
between experimental data (literature) and measured data (QSAR model).

Conclusion:

A QSAR model equation was established and used to predict removal efficiency of 57
PPCPs; the results obtained showed goodness of fit, R2 greater than 0.90 indicating that the internal
and external validations were also performed on the model.
Moralitas politik dalam pemilu 2004 dan implikasinya bagi Pendidikan Kewarganegaraan
Authors: Cholisin Cholisin
Published: February 2020

Morality in general election 2004, a long way off from expected. Various actions which dissolute political indication see clearly in course of and result of general election. Money politics, administrative collusion and crime by some of all legislative candidates, bureaucracy which not yet neutral politically, manipulation of voice enumeration, showing process of general election still not yet full respect the moral. General election also did not yet shown to yield all politician owning high binding (commitment) to respect the political morality. Its indication, general election not yet earned to yield the leader owning inner calm and trusted by people, general election tends to yield the politician principled weak politics party at ideology so that progressively strengthen to expand "political of corruption. " Not yet strength of political morality in general election 2004 represented factor which did not conducive for civic education, because real reference of citizen about how politicians have moral. This circumstance if let it can conducive to the belief crisis to existing political system. Therefore, study of civic education agreed with general election which require to be developed critically to form the rational and proportional attitude in general election. If this matter is done will be able to assist to overcome to expand belief crisis to general election and national of political system.
Telaah kritis terhadap Undang-Undang No. 32 Tahun 2004 tentang Pemerintahan Daerah
Authors: Suharno Suharno
Published: February 2020

The Constitution (UUD 1945) actually gave an opportunity for implementation of decentralist governmental system. But the New Order's Regime was not given enough manual for institutionalized decentralist government system. The idea to implement decentralist government system keep roll on until the issue of the Bill on Local Government No.32 Tabun 2004 as a completion of its previous. The wide authority to implement local governmental autonomy given by that bill implied politically as the discretion, scope and volume of local politic being wider and by managerial also make the tasks and responsibility of local government being wider and heavier.
Effect of a WeChat-Based Intervention (Run4Love) on Depressive Symptoms Among People Living With HIV in China: A Randomized Controlled Trial
Authors: Guo Yan , Hong Y Alicia , Cai Weiping , Li Linghua , Hao Yuantao , Qiao Jiaying , Xu Zhimeng , Zhang Hanxi , Zeng Chengbo , Liu Cong , Li Yiran , Zhu Mengting , Zeng Yu , Penedo Frank J
Published: February 2020

Background

People living with HIV (PLWH) have high rates of depressive symptoms. However, only a few effective mental health interventions exist for this vulnerable population.

Objective

The aim of this study was to assess the efficacy of a WeChat-based intervention, Run4Love, with a randomized controlled trial among 300 people living with HIV and depression (PLWHD) in China.

Methods

We recruited PLWH from the HIV outpatient clinic in South China. Participants were screened based on the Center for Epidemiologic Studies-Depression (CES-D) scale. Those who scored 16 or higher were eligible to participate. A total of 300 eligible patients were enrolled. After obtaining informed consent from the participants, completion of a baseline survey, and collection of participants’ hair samples for measuring cortisol, the participants were randomly assigned to an intervention or a control group in a 1:1 ratio. The intervention group received the Run4Love program, delivered via the popular social media app WeChat. Cognitive behavioral stress management courses and weekly reminders of exercise were delivered in a multimedia format. Participants’ progress was monitored with timely and tailored feedback. The control group received usual care and a brochure on nutrition for PLWH. Data were collected at 3, 6, and 9 months. The primary outcome was depression, which was measured by a validated instrument.

Results

Participants in the intervention and control groups were comparable at baseline; about 91.3% (139/150), 88.3% (132/150), and 86.7% (130/150) participants completed the 3-, 6-, and 9-month follow-ups, respectively. At the 3-month follow-up, a significant reduction in CES-D score was observed in the intervention group (from 23.9 to 17.7 vs from 24.3 to 23.8; mean difference=−5.77, 95% CI −7.82 to −3.71; P<.001; standard effect size d=0.66). The mean changes in CES-D score from baseline to the 6- and 9-month follow-ups between the two groups remained statistically significant. No adverse events were reported.

Conclusions

The WeChat-based mobile health (mHealth) intervention Run4Love significantly reduced depressive symptoms among PLWHD, and the effect was sustained. An app-based mHealth intervention could provide a feasible therapeutic option for many PLWHD in resource-limited settings. Further research is needed to assess generalizability and cost-effectiveness of this intervention.

Trial Registration

Chinese Clinical Trial Registry ChiCTR-IPR-17012606; http://www.chictr.org.cn/showproj.aspx?proj=21019 (Archived by WebCite at https://www.webcitation.org/78Bw2vouF)
HoloLens-Based Vascular Localization System: Precision Evaluation Study With a Three-Dimensional Printed Model
Authors: Jiang Taoran , Yu Dewang , Wang Yuqi , Zan Tao , Wang Shuyi , Li Qingfeng
Published: February 2020

Background

Vascular localization is crucial for perforator flap transfer. Augmented reality offers a novel method to seamlessly combine real information with virtual objects created by computed tomographic angiography to help the surgeon “see through” the skin and precisely localize the perforator. The head-mounted display augmented reality system HoloLens (Microsoft) could facilitate augmented reality–based perforator localization for a more convenient and safe procedure.

Objective

The aim of this study was to evaluate the precision of the HoloLens-based vascular localization system, as the most important performance indicator of a new localization system.

Methods

The precision of the HoloLens-based vascular localization system was tested in a simulated operating room under different conditions with a three-dimensional (3D) printed model. The coordinates of five pairs of points on the vascular map that could be easily identified on the 3D printed model and virtual model were detected by a probe, and the distance between the corresponding points was calculated as the navigation error.

Results

The mean errors were determined under different conditions, with a minimum error of 1.35 mm (SD 0.43) and maximum error of 3.18 mm (SD 1.32), which were within the clinically acceptable range. There were no significant differences in the errors obtained under different visual angles, different light intensities, or different states (static or motion). However, the error was larger when tested with light compared with that tested without light.

Conclusions

This precision evaluation demonstrated that the HoloLens system can precisely localize the perforator and potentially help the surgeon accomplish the operation. The authors recommend using HoloLens-based surgical navigation without light.
Heart Rate and Oxygen Saturation Monitoring With a New Wearable Wireless Device in the Intensive Care Unit: Pilot Comparison Trial (Preprint)
Authors: Murali Srinivasan , Rincon Francisco , Cassina Tiziano , Cook Stephane , Goy Jean-Jacques
Published: February 2020

BACKGROUND

Continuous cardiac monitoring with wireless sensors is an attractive option for early detection of arrhythmia and conduction disturbances and the prevention of adverse events leading to patient deterioration. We present a new sensor design (SmartCardia), a wearable wireless biosensor patch, for continuous cardiac and oxygen saturation (SpO2) monitoring.

OBJECTIVE

This study aimed to test the clinical value of a new wireless sensor device (SmartCardia) and its usefulness in monitoring the heart rate (HR) and SpO2 of patients.

METHODS

We performed an observational study and monitored the HR and SpO2 of patients admitted to the intensive care unit (ICU). We compared the device under test (SmartCardia) with the ICU-grade monitoring system (Dräger-Healthcare). We defined optimal correlation between the gold standard and the wireless system as <10% difference for HR and <4% difference for SpO2. Data loss and discrepancy between the two systems were critically analyzed.

RESULTS

A total of 58 ICU patients (42 men and 16 women), with a mean age of 71 years (SD 11), were included in this study. A total of 13.49 (SD 5.53) hours per patient were recorded. This represents a total recorded period of 782.3 hours. The mean difference between the HR detected by the SmartCardia patch and the ICU monitor was 5.87 (SD 16.01) beats per minute (bias=–5.66, SD 16.09). For SpO2, the average difference was 3.54% (SD 3.86; bias=2.9, SD 4.36) for interpretable values. SmartCardia’s patch measures SpO2 only under low-to-no activity conditions and otherwise does not report a value. Data loss and noninterpretable values of SpO2 represented 26% (SD 24) of total measurements.

CONCLUSIONS

The SmartCardia device demonstrated clinically acceptable accuracy for HR and SpO2 monitoring in ICU patients.
Функциональная диспепсия у детей. Проблемы и перспективы симптоматической терапии
Authors: Belousova O.Yu. , Kazaryan L.V.
Published: February 2020

Статья посвящена проблеме функциональной диспепсии. Функциональная диспепсия характеризуется разнообразными неспецифичными симптомами, такими как дискомфорт, ранняя сытость, тошнота, боль в эпигастральной области или ощущение жжения в эпигастрии. Перечисленные симптомы характерны не только для функциональной диспепсии, но и для других функциональных гастроинтестинальных расстройств, таких как гастроэзофагеальная рефлюксная болезнь или синдром раздраженного кишечника, поэтому диагноз функциональной диспепсии требует уточнения. Патофизиология функциональной диспепсии до конца не изучена. Считается, что заболевание может быть связано с воспалением верхних отделов желудочно-кишечного тракта и нарушениями моторики, которые могут быть вызваны инфекционным или аллергенным агентом или изменениями со стороны микробиома кишечника. Несмотря на то, что функциональная диспепсия вызывает беспокойство и влияет на качество жизни, она обычно не прогрессирует и имеет благоприятные течение и исход. Есть много доступных вариантов лечения с различными уровнями доказательств эффективности. К ним относятся изменение рациона питания, подавление факторов агрессии, применение прокинетических препаратов, или прокинетиков, трициклических антидепрессантов и психологическая терапия. Препаратами первой линии терапии функциональной диспепсии являются прокинетики и ингибиторы протонной помпы. В статье уделено внимание препарату Домрид, содержащему домперидон (прокинетик).
Клинический случай диагностики поздней стадии ВИЧ-инфекции у подростка с хореей
Authors: Borysova T.P. , Badogina L.P. , Allahverdieva Z.S. , Nikolaenko T.A. , Zabolotnaja L.D. , Gerasimova N.V.
Published: February 2020

ВИЧ-инфекция среди возможных этиологических факторов неврологической патологии пока рассматривается редко, что приводит к поздней диагностике заболевания и несвоевременному началу специфической терапии. Неврологические проявления заболевания могут возникать в связи с прямым воздействием ВИЧ на нервную систему, оппортунистическими инфекциями и злокачественными новообразованиями, нейротоксичными эффектами антиретровирусного лечения и другими системными осложнениями. ВИЧ-ассоциированные неврологические расстройства вариабельны и представлены нейрокогнитивными нарушениями, энцефалопатией, миелопатией, полинейропатией, асептическим менингитом (менингоэнцефалитом). ВИЧ-энцефалопатия у детей проявляется в форме эмоциональных, когнитивных, двигательных, речевых нарушений. У взрослых больных как возможный клинический вариант ВИЧ-энцефалопатии рассматривается синдром хореи. В доступной литературе мы не встретили сообщений о развитии хорееподобного синдрома у ВИЧ-инфицированных детей. Описанный клинический случай демонстрирует диагностику поздней стадии ВИЧ-инфекции у ребенка 13 лет с синдромом хореи. Представленное клиническое наблюдение демонстрирует сложности диагностики ВИЧ-энцефалопатии у ребенка, что было связано с редким проявлением данного заболевания в детском возрасте в виде генерализованных гиперкинезов, а также с сокрытием матерью анамнестических данных о наличии у нее ВИЧ-инфекции. Таким образом, у детей с хореей диагноз возможен только при исключении заболеваний, ее вызывающих, а именно острой ревматической лихорадки, системного заболевания соединительной ткани, демиелинизирующих заболеваний, объемно-органической патологии центральной нервной системы, болезни Вильсона — Коновалова, а также ВИЧ-инфекции.