bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Figures 6 - 11 from Single-Molecule Genomic Data Delineate Patient-Specific Tumor Profiles and Cancer Stem Cell Organization
Authors: Sottoriva Andrea , Spiteri Inmaculada , Shibata Darryl , Curtis Christina , Tavaré Simon
Published: April 2023

PDF file - 63K, Figure S6. Inferred parameters G and a for ZNF454 and SLC5A7. For the transit amplifying stages parameter G and the apoptosis rate a, we report agreement of multiple molecular clocks. Figure S7. Heterogeneity induced by different gland splitting algorithms. In our model we implemented the gland fission mechanism as the equal division of the cell population into the two daughter cells. Although this is the most commonly advocated method of gland splitting, an alternative scenario is to consider a single founding cell for the new gland. We predict that this would substantially increase the level of heterogeneity in the glands, due to the increased number of cell divisions required by the founding CSC to grow the new gland. We do not consider this alternative process in our analysis. Figure S8. Prior distributions used in SCAI. We used non-informative priors for our analysis. However, some parameter values are less likely to yield a tumor. For example, a high apoptotic rate may completely extinguish the CSC population when this is small enough. For this reason, the symmetric division rate and apoptosis rate are not taken to be uniform. The tumor age is a secondary parameter that results from the combination of all the other parameters. Figure S9. Validation of the SCAI framework with an 8 CpG-long synthetic dataset. Using synthetic dataset with a molecular clock made by 8 CpGs produces very similar results to a synthetic dataset with 16 CpGs-long clocks. Figure S10. Patient-specific inference results for a single copy of IRX2. Inference results considering a haploid version of the IRX2 locus in each cell (e.g. due to copy number loss), are very similar to the results obtained by considering 2 copies of IRX2 per cell. This confirms the robustness of our analysis to copy number alterations. Moreover copy number changes of the IRX2 locus in CRC are reported in an extremely limited number of cases (~0.3%). Figure S11. Expected variation in summary statistics for different sequencing depths. The simulation of different sampling depths from the same gland reveals a considerable difference in summary statistics, particularly for the number of patterns, singletons, Kolmogorov distance and Shannon index.
Supplementary Figures 1 - 5 from Single-Molecule Genomic Data Delineate Patient-Specific Tumor Profiles and Cancer Stem Cell Organization
Authors: Sottoriva Andrea , Spiteri Inmaculada , Shibata Darryl , Curtis Christina , Tavaré Simon
Published: April 2023

PDF file - 100K, Figure S1. Validity of the IRX2 molecular clock. Our analysis is based on the neutrality of methylation mutations at specific genomic loci. Data from human autopsy-derived normal samples show that the IRX2 locus exhibits age-related increase in methylation in mitotic tissue (colon), but consistently low methylation in non-dividing tissues (heart and brain) and neutrophils. This is evidence of the neutral behavior of the locus. Figure S2. Validation of the SCAI framework with synthetic data. With our tumor growth model we generated synthetic data and verified that for different parameter combinations our framework is indeed able to infer the correct values (denoted by red triangles). We report a very high success rate for all the parameters except for the number of transit amplifying stages, G. The reason for this is that short-living TACs leave a very dim molecular signal in the methylation data. Yet, this problem does not affect our ability to correctly recover the CSC fraction (column A). Figure S3. Tumor organization parameters. The CSC fraction ξ depends on the symmetric division rate ψ and the number of transit stages G. When ξ is large the tumor tends to exhibit a classical or purely clonal organization, whereas low values correspond to a CSC organization. Large values of G also decrease the CSC fraction by amplifying the differentiating compartment of the tumor population. Figure S4. Validation of ZNF454 and SLC5A7 as molecular clocks. Both ZNF454 (A) and SLC5A7 (B) display consistently low methylation levels in non-dividing tissues (heart and brain) and neutrophils, but age-related methylation in mitotic tissues like the colon. All samples refer to normal human tissues derived from autopsies. Figure S5. Inference on tumor Z using different molecular clocks. For tumor Z, two additional molecular clocks were assayed: ZNF454 and SLC5A7. For all loci, glands cluster by tumor side (A), moreover they all yield very similar results in terms of the posterior distributions of tumor parameters (B). Relatively small differences in results were noted for the SLC5A7 locus, we argue that that is due to the much lower yield in terms of reads per gland (5 fold lower) than the others clocks, as well as due to the reduced length of the clock (6 CpGs). Overall, these results demonstrate that for the same tumor, different molecular clocks carry comparable information on the mitotic history of the malignancy.
Supplementary Figure 3 from Comparative Expression Analysis Reveals Lineage Relationships between Human and Murine Gliomas and a Dominance of Glial Signatures during Tumor Propagation In Vitro
Authors: Henriquez Nico V. , Forshew Tim , Tatevossian Ruth , Ellis Matthew , Richard-Loendt Angela , Rogers Hazel , Jacques Thomas S. , Reitboeck Pablo Garcia , Pearce Kerra , Sheer Denise , Grundy Richard G. , Brandner Sebastian
Published: April 2023

PDF file, 824K, Restricted tumourigenesis in a Rb/Pten background.
Supplementary Figure 2 from Comparative Expression Analysis Reveals Lineage Relationships between Human and Murine Gliomas and a Dominance of Glial Signatures during Tumor Propagation In Vitro
Authors: Henriquez Nico V. , Forshew Tim , Tatevossian Ruth , Ellis Matthew , Richard-Loendt Angela , Rogers Hazel , Jacques Thomas S. , Reitboeck Pablo Garcia , Pearce Kerra , Sheer Denise , Grundy Richard G. , Brandner Sebastian
Published: April 2023

PDF file, 871K, Expression patterns of tumours generated in a p53/Rb background.
Supplementary Material from Epigenetic Regulator Smchd1 Functions as a Tumor Suppressor
Authors: Leong Huei San , Chen Kelan , Hu Yifang , Lee Stanley , Corbin Jason , Pakusch Miha , Murphy James M. , Majewski Ian J. , Smyth Gordon K. , Alexander Warren S. , Hilton Douglas J. , Blewitt Marnie E.
Published: April 2023

Supplementary Material PDF file - 709K, Supplementary Tables 1 and 2, supplementary methods, supplementary figure legends and supplementary figures
Supplementary Table 2 from Complex Tumor Genomes Inferred from Single Circulating Tumor Cells by Array-CGH and Next-Generation Sequencing
Authors: Heitzer Ellen , Auer Martina , Gasch Christin , Pichler Martin , Ulz Peter , Hoffmann Eva Maria , Lax Sigurd , Waldispuehl-Geigl Julie , Mauermann Oliver , Lackner Carolin , Höfler Gerald , Eisner Florian , Sill Heinz , Samonigg Hellmut , Pantel Klaus , Riethdorf Sabine , Bauernhofer Thomas , Geigl Jochen B. , Speicher Michael R.
Published: April 2023

PDF file - 95K, List of 68 genes, which, according to the COSMIC database, are frequently mutated in colorectal carcinoma (CRC) and analyzed in our study.
Supplementary Table 1 from Complex Tumor Genomes Inferred from Single Circulating Tumor Cells by Array-CGH and Next-Generation Sequencing
Authors: Heitzer Ellen , Auer Martina , Gasch Christin , Pichler Martin , Ulz Peter , Hoffmann Eva Maria , Lax Sigurd , Waldispuehl-Geigl Julie , Mauermann Oliver , Lackner Carolin , Höfler Gerald , Eisner Florian , Sill Heinz , Samonigg Hellmut , Pantel Klaus , Riethdorf Sabine , Bauernhofer Thomas , Geigl Jochen B. , Speicher Michael R.
Published: April 2023

PDF file - 98K, Summary of clinical characteristics of the 6 colorectal carcinoma (CRC) patients.
Supplementary Figure 8 from Complex Tumor Genomes Inferred from Single Circulating Tumor Cells by Array-CGH and Next-Generation Sequencing
Authors: Heitzer Ellen , Auer Martina , Gasch Christin , Pichler Martin , Ulz Peter , Hoffmann Eva Maria , Lax Sigurd , Waldispuehl-Geigl Julie , Mauermann Oliver , Lackner Carolin , Höfler Gerald , Eisner Florian , Sill Heinz , Samonigg Hellmut , Pantel Klaus , Riethdorf Sabine , Bauernhofer Thomas , Geigl Jochen B. , Speicher Michael R.
Published: April 2023

PDF file - 3383K, Calculation of different integer copy number profiles for CTC03 from patient #6 assuming diploidy (a), triploidy (b), or tetraploidy (c) and the respective array CGH profile (d).
Supplementary Material 4 from Androgen Glucuronidation: An Unexpected Target for Androgen Deprivation Therapy, with Prognosis and Diagnostic Implications
Authors: Grosse Laurent , Pâquet Sophie , Caron Patrick , Fazli Ladan , Rennie Paul S. , Bélanger Alain , Barbier Olivier
Published: April 2023

PDF file - 8925K, Supplementary material 4: Representative examples of immunoexpression obtained after incubation of prostate tissue microarrays with the anti-UGT2B15, anti-UGT2B17 or anti-vimentin antibodies: Comparison Untreated vs ADTh for 1.5 and 2.0 months.
Supplementary Material 3 from Androgen Glucuronidation: An Unexpected Target for Androgen Deprivation Therapy, with Prognosis and Diagnostic Implications
Authors: Grosse Laurent , Pâquet Sophie , Caron Patrick , Fazli Ladan , Rennie Paul S. , Bélanger Alain , Barbier Olivier
Published: April 2023

PDF file - 7458K, Supplementary material 3: Representative examples of immunoexpression obtained after incubation of prostate tissue microarrays with the anti-UGT2B15, anti-UGT2B17 or anti-vimentin antibodies: Comparison BPH vs Untreated.
Supplementary Methods from Differential Contributions of STAT5A and STAT5B to Stress Protection and Tyrosine Kinase Inhibitor Resistance of Chronic Myeloid Leukemia Stem/Progenitor Cells
Authors: Casetti Luana , Martin-Lannerée Séverine , Najjar Imen , Plo Isabelle , Augé Sylvie , Roy Lydia , Chomel Jean-Claude , Lauret Evelyne , Turhan Ali G. , Dusanter-Fourt Isabelle
Published: April 2023

PDF file - 34K, Includes lentiviral constructs and transduction, immunoblots and antibodies, RNA extraction data, and supplementary references.
Supplementary Figure Legends from Cyclin D1 Integrates Estrogen-Mediated DNA Damage Repair Signaling
Authors: Li Zhiping , Chen Ke , Jiao Xuanmao , Wang Chenguang , Willmarth Nicole E. , Casimiro Mathew C. , Li Weihua , Ju Xiaoming , Kim Sung Hoon , Lisanti Michael P. , Katzenellenbogen John A. , Pestell Richard G.
Published: April 2023

PDF file - 22KB
Supplementary Video 6 from Senescent Fibroblasts in Melanoma Initiation and Progression: An Integrated Theoretical, Experimental, and Clinical Approach
Authors: Kim Eunjung , Rebecca Vito , Fedorenko Inna V. , Messina Jane L. , Mathew Rahel , Maria-Engler Silvya S. , Basanta David , Smalley Keiran S.M. , Anderson Alexander R.A.
Published: April 2023

MOV file - 6949K, This video shows the spatio-temporal evolution of vSkin that produced Figure 6B (minimally transformed melanocytes and mildly senescent fibroblasts).
Supplementary Figure 5 from Transient Antiangiogenic Treatment Improves Delivery of Cytotoxic Compounds and Therapeutic Outcome in Lung Cancer
Authors: Chatterjee Sampurna , Wieczorek Caroline , Schöttle Jakob , Siobal Maike , Hinze Yvonne , Franz Thomas , Florin Alexandra , Adamczak Joanna , Heukamp Lukas C. , Neumaier Bernd , Ullrich Roland T.
Published: April 2023

PDF file - 357KB, Changes of mean voxel radioactivity of 15OH2O PET and tumor growth during intermittent PTK787 treatment.
Supplementary Figure 3 from Mature Cytotoxic CD56bright/CD16+ Natural Killer Cells Can Infiltrate Lymph Nodes Adjacent to Metastatic Melanoma
Authors: Messaoudene Meriem , Fregni Giulia , Fourmentraux-Neves Emmanuelle , Chanal Johan , Maubec Eve , Mazouz-Dorval Sarra , Couturaud Benoit , Girod Angelique , Sastre-Garau Xavier , Albert Sebastien , Guédon Charles , Deschamps Lydia , Mitilian Delphine , Cremer Isabelle , Jacquelot Nicolas , Rusakiewicz Sylvie , Zitvogel Laurence , Avril Marie-Francoise , Caignard Anne
Published: April 2023

PDF file - 339K, Phenotype of M-LN NK cells in function of the disease stage.
Supplementary Information from Hyperactivated JNK Is a Therapeutic Target in pVHL-Deficient Renal Cell Carcinoma
Authors: An Jiabin , Liu Huiren , Magyar Clara E. , Guo Yanchuan , Veena Mysore S. , Srivatsan Eri S. , Huang Jiaoti , Rettig Matthew B.
Published: April 2023

Supplementary Information PDF file - 24991K, Hyperactivated c-Jun N-terminal Kinase as a Therapeutic Target in pVHL-Deficient Renal Cell Carcinomas. Supplementary Materials and Methods. Six (6) supplementary figures. Two (2) supplementary tables. Supplementary Figure S1. pVHL and HIF1� levels in isogenic pairs of RCC cell lines. Supplementary Figure S2. JNK regulates AP1 activity. Supplementary Figure S3. CARD9 silencing inhibits TAK1 functional activity. Supplementary Figure S4. JNK/AP1-dependent EMT in pVHL-deficient RCCs. Supplementary Figure S5. Changes in expression of cadherins and transcription factors resulting from pharmacologic inhibition of JNK in pVHL-deficient cells Supplementary Figure S6. Inhibition of JNK or c-Jun reduces the invasiveness of pVHL-deficient cells. Supplementary Table 1: Phospho-c-Jun Staining in RCC Specimens
Supplementary Video 8 from Endogenous Two-Photon Fluorescence Imaging Elucidates Metabolic Changes Related to Enhanced Glycolysis and Glutamine Consumption in Precancerous Epithelial Tissues
Authors: Varone Antonio , Xylas Joanna , Quinn Kyle P. , Pouli Dimitra , Sridharan Gautham , McLaughlin-Drubin Margaret E. , Alonzo Carlo , Lee Kyongbum , Münger Karl , Georgakoudi Irene
Published: April 2023

AVI file - 1366KB, Representative 3D RENDERING E6E7 EETE.
Supplementary Video 6 from Endogenous Two-Photon Fluorescence Imaging Elucidates Metabolic Changes Related to Enhanced Glycolysis and Glutamine Consumption in Precancerous Epithelial Tissues
Authors: Varone Antonio , Xylas Joanna , Quinn Kyle P. , Pouli Dimitra , Sridharan Gautham , McLaughlin-Drubin Margaret E. , Alonzo Carlo , Lee Kyongbum , Münger Karl , Georgakoudi Irene
Published: April 2023

AVI file - 1297KB, Representative 3D RENDERING E7 EETE.
Supplementary Figure 4 from Mixed Lineage Kinase MLK4 Is Activated in Colorectal Cancers Where It Synergistically Cooperates with Activated RAS Signaling in Driving Tumorigenesis
Authors: Martini Miriam , Russo Mariangela , Lamba Simona , Vitiello Elisa , Crowley Emily Hannah , Sassi Francesco , Romanelli Davide , Frattini Milo , Marchetti Antonio , Bardelli Alberto
Published: April 2023

PDF file - 161K, Ctrl and MLK4 knock down DLD were seeded and allowed to grow for the indicated times in flasks with ultra-low attachment surface to prevent cell adhesion. Cells were harvested and protein lysates were subjected to western blotting with the indicated antibodies.
Supplementary Figure 2 from Natural Human Plasmacytoid Dendritic Cells Induce Antigen-Specific T-Cell Responses in Melanoma Patients
Authors: Tel Jurjen , Aarntzen Erik H.J.G. , Baba Tetsuro , Schreibelt Gerty , Schulte Barbara M. , Benitez-Ribas Daniel , Boerman Otto C. , Croockewit Sandra , Oyen Wim J.G. , van Rossum Michelle , Winkels Gregor , Coulie Pierre G. , Punt Cornelis J.A. , Figdor Carl G. , de Vries I. Jolanda M.
Published: April 2023

Supplementary Figure 2 PDF file - 46K, Supplementary Figure 2 Plasmacytoid DCs acquire CCL21-driven chemotactic ability upon activation
Supplementary Methods from Myeloid-Specific Expression of Ron Receptor Kinase Promotes Prostate Tumor Growth
Authors: Gurusamy Devikala , Gray Jerilyn K. , Pathrose Peterson , Kulkarni Rishikesh M. , Finkleman Fred D. , Waltz Susan E.
Published: April 2023

PDF file - 79K
Supplementary Figure 6 from Myeloid-Specific Expression of Ron Receptor Kinase Promotes Prostate Tumor Growth
Authors: Gurusamy Devikala , Gray Jerilyn K. , Pathrose Peterson , Kulkarni Rishikesh M. , Finkleman Fred D. , Waltz Susan E.
Published: April 2023

PDF file - 303K, Quantification of T-cells in tumors and spleens. For Review and Publication Both.
Supplementary Figure 4 from Myeloid-Specific Expression of Ron Receptor Kinase Promotes Prostate Tumor Growth
Authors: Gurusamy Devikala , Gray Jerilyn K. , Pathrose Peterson , Kulkarni Rishikesh M. , Finkleman Fred D. , Waltz Susan E.
Published: April 2023

PDF file - 101K, FACs analysis of bone marrow derived cells from TK+/+ and TK-/- mice. For Review and Publication Both.
Supplementary Figure Legend from PTEN Loss Mitigates the Response of Medulloblastoma to Hedgehog Pathway Inhibition
Authors: Metcalfe Ciara , Alicke Bruno , Crow Ailey , Lamoureux Marlea , Dijkgraaf Gerrit J.P. , Peale Franklin , Gould Stephen E. , de Sauvage Frederic J.
Published: April 2023

PDF file - 57K
Supplementary Figure 7 from Therapeutic PD-1 Pathway Blockade Augments with Other Modalities of Immunotherapy T-Cell Function to Prevent Immune Decline in Ovarian Cancer
Authors: Duraiswamy Jaikumar , Freeman Gordon J. , Coukos George
Published: April 2023

PDF file, 120K, FVAX in combination with aPD-L1 and a4-1BB treatment promotes lymphocyte infiltration into the tumor.
Supplementary Figure Legends from Cholesterol Loading and Ultrastable Protein Interactions Determine the Level of Tumor Marker Required for Optimal Isolation of Cancer Cells
Authors: Jain Jayati , Veggiani Gianluca , Howarth Mark
Published: April 2023

Supplementary Figure Legends PDF file - 73K, Legend for Supplementary Figures S1-S9
Supplementary Figure 3 from Genome-wide Profiling of AP-1–Regulated Transcription Provides Insights into the Invasiveness of Triple-Negative Breast Cancer
Authors: Zhao Chunyan , Qiao Yichun , Jonsson Philip , Wang Jian , Xu Li , Rouhi Pegah , Sinha Indranil , Cao Yihai , Williams Cecilia , Dahlman-Wright Karin
Published: April 2023

PDF file - 105KB, Fra-1 or c-Jun depletion reduces proliferation.
Supplementary Table 1 from Genomic Aberrations Occurring in Subsets of Serrated Colorectal Lesions but not Conventional Adenomas
Authors: Burnett-Hartman Andrea N. , Newcomb Polly A. , Potter John D. , Passarelli Michael N. , Phipps Amanda I. , Wurscher Michelle A. , Grady William M. , Zhu Lee-Ching , Upton Melissa P. , Makar Karen W.
Published: April 2023

Supplementary Table 1 - PDF file 74K, Prevalence of serrated lesion subtypes with mutant BRAF, CIMP-high, and methylated MLH1: Group Health Enrollees 1998-2007
Supplementary Figure 4 from Phosphatidylinositol 4-Phosphate in the Golgi Apparatus Regulates Cell–Cell Adhesion and Invasive Cell Migration in Human Breast Cancer
Authors: Tokuda Emi , Itoh Toshiki , Hasegawa Junya , Ijuin Takeshi , Takeuchi Yukiko , Irino Yasuhiro , Fukumoto Miki , Takenawa Tadaomi
Published: April 2023

PDF file - 263K, Supplementary Figure 4. Knockdown of PI4K variants.
Supplementary Figure 1 from Phosphatidylinositol 4-Phosphate in the Golgi Apparatus Regulates Cell–Cell Adhesion and Invasive Cell Migration in Human Breast Cancer
Authors: Tokuda Emi , Itoh Toshiki , Hasegawa Junya , Ijuin Takeshi , Takeuchi Yukiko , Irino Yasuhiro , Fukumoto Miki , Takenawa Tadaomi
Published: April 2023

PDF file - 235K, Supplementary Figure 1. Knockdown of SAC1 in T47D cells.
Supplementary Figure 3 from Dual Targeting of EGFR and HER3 with MEHD7945A Overcomes Acquired Resistance to EGFR Inhibitors and Radiation
Authors: Huang Shyhmin , Li Chunrong , Armstrong Eric A. , Peet Chimera R. , Saker Jarob , Amler Lukas C. , Sliwkowski Mark X. , Harari Paul M.
Published: April 2023

PDF file - 52KB, MEHD7945A is more potent than the combination of cetuximab and erlotinib
Supplementary Figure 4 from Selective Blockade of Matrix Metalloprotease-14 with a Monoclonal Antibody Abrogates Invasion, Angiogenesis, and Tumor Growth in Ovarian Cancer
Authors: Kaimal Rajani , Aljumaily Raid , Tressel Sarah L. , Pradhan Rutika V. , Covic Lidija , Kuliopulos Athan , Zarwan Corrine , Kim Young B. , Sharifi Sheida , Agarwal Anika
Published: April 2023

PDF file - 418K, MMP-14 Ab inhibits invasion and metastasis in peritoneal ovarian cancer
Supplementary Figure 3 from Selective Blockade of Matrix Metalloprotease-14 with a Monoclonal Antibody Abrogates Invasion, Angiogenesis, and Tumor Growth in Ovarian Cancer
Authors: Kaimal Rajani , Aljumaily Raid , Tressel Sarah L. , Pradhan Rutika V. , Covic Lidija , Kuliopulos Athan , Zarwan Corrine , Kim Young B. , Sharifi Sheida , Agarwal Anika
Published: April 2023

PDF file - 420K, MMP-14 regulates MMP-9 gene expression in OVCAR-4 ovarian cancer cells
Supplementary Figure 1 from Selective Blockade of Matrix Metalloprotease-14 with a Monoclonal Antibody Abrogates Invasion, Angiogenesis, and Tumor Growth in Ovarian Cancer
Authors: Kaimal Rajani , Aljumaily Raid , Tressel Sarah L. , Pradhan Rutika V. , Covic Lidija , Kuliopulos Athan , Zarwan Corrine , Kim Young B. , Sharifi Sheida , Agarwal Anika
Published: April 2023

PDF file - 121K, Knockdown of MMP-14 following MMP-14 RNAi of OVCAR-4 and OVCAR-3 cells
Supplementary Table 1 from Proliferation-Independent Control of Tumor Glycolysis by PDGFR-Mediated AKT Activation
Authors: Ran Cong , Liu Huan , Hitoshi Yasuyuki , Israel Mark A.
Published: April 2023

PDF file - 41K, Table S1. RT-PCR Primer Sequences.
Supplementary Figure 5 from CSF1R Signaling Blockade Stanches Tumor-Infiltrating Myeloid Cells and Improves the Efficacy of Radiotherapy in Prostate Cancer
Authors: Xu Jingying , Escamilla Jemima , Mok Stephen , David John , Priceman Saul , West Brian , Bollag Gideon , McBride William , Wu Lily
Published: April 2023

PDF file - 3509K, Supplemental figure 5: CSF1/CSF1R blockade by GW2580 inhibits tumor growth after irradiation.
Supplementary Figure 5 from Proliferation-Independent Control of Tumor Glycolysis by PDGFR-Mediated AKT Activation
Authors: Ran Cong , Liu Huan , Hitoshi Yasuyuki , Israel Mark A.
Published: April 2023

PDF file - 159K, Figure S5. Preparation of dox-resistant, TSC cultures from GFAP-tTA:TRE-hPDGFB mice.
Supplementary Figure 3 from CSF1R Signaling Blockade Stanches Tumor-Infiltrating Myeloid Cells and Improves the Efficacy of Radiotherapy in Prostate Cancer
Authors: Xu Jingying , Escamilla Jemima , Mok Stephen , David John , Priceman Saul , West Brian , Bollag Gideon , McBride William , Wu Lily
Published: April 2023

PDF file - 2858K, Supplemental figure 3: Irradiation increases CSF1 expression in other human and murine cancer cell lines.
Supplementary Figure 3 from Proliferation-Independent Control of Tumor Glycolysis by PDGFR-Mediated AKT Activation
Authors: Ran Cong , Liu Huan , Hitoshi Yasuyuki , Israel Mark A.
Published: April 2023

PDF file - 52K, Figure S3. PDGF signaling regulates intracellular ATP levels.
Supplementary Figure 2 from CSF1R Signaling Blockade Stanches Tumor-Infiltrating Myeloid Cells and Improves the Efficacy of Radiotherapy in Prostate Cancer
Authors: Xu Jingying , Escamilla Jemima , Mok Stephen , David John , Priceman Saul , West Brian , Bollag Gideon , McBride William , Wu Lily
Published: April 2023

PDF file - 1720K, Supplemental figure 2: Local irradiation enhances recruitment of TAMs to tumors in Myc-CaP model.
Supplementary Figure 2 from Proliferation-Independent Control of Tumor Glycolysis by PDGFR-Mediated AKT Activation
Authors: Ran Cong , Liu Huan , Hitoshi Yasuyuki , Israel Mark A.
Published: April 2023

PDF file - 74K, Figure S2. PDGFR activation alters expression of molecules that are key regulators of glycolysis.
Supplementary Figure 1 from Proliferation-Independent Control of Tumor Glycolysis by PDGFR-Mediated AKT Activation
Authors: Ran Cong , Liu Huan , Hitoshi Yasuyuki , Israel Mark A.
Published: April 2023

PDF file - 110K, Figure S1. Doxycyline inhibits growth but not survival in dox-sensitive TSC cultures.
Supplementary Figure Legend from Cisplatin Hypersensitivity of Testicular Germ Cell Tumors Is Determined by High Constitutive Noxa Levels Mediated by Oct-4
Authors: Gutekunst Matthias , Mueller Thomas , Weilbacher Andrea , Dengler Michael A. , Bedke Jens , Kruck Stephan , Oren Moshe , Aulitzky Walter E. , van der Kuip Heiko
Published: April 2023

PDF file - 79K
Supplemental Figure 4 from Mast Cell–Derived Prostaglandin D2 Inhibits Colitis and Colitis-Associated Colon Cancer in Mice
Authors: Iwanaga Koichi , Nakamura Tatsuro , Maeda Shingo , Aritake Kosuke , Hori Masatoshi , Urade Yoshihiro , Ozaki Hiroshi , Murata Takahisa
Published: April 2023

Supplemental Figure
Supplementary Figure 4 from Cisplatin Hypersensitivity of Testicular Germ Cell Tumors Is Determined by High Constitutive Noxa Levels Mediated by Oct-4
Authors: Gutekunst Matthias , Mueller Thomas , Weilbacher Andrea , Dengler Michael A. , Bedke Jens , Kruck Stephan , Oren Moshe , Aulitzky Walter E. , van der Kuip Heiko
Published: April 2023

PDF file - 39K, Nutlin-3 sensitivity is correlated with Oct-4 and Noxa protein levels
Supplemental Figure 3 from Mast Cell–Derived Prostaglandin D2 Inhibits Colitis and Colitis-Associated Colon Cancer in Mice
Authors: Iwanaga Koichi , Nakamura Tatsuro , Maeda Shingo , Aritake Kosuke , Hori Masatoshi , Urade Yoshihiro , Ozaki Hiroshi , Murata Takahisa
Published: April 2023

Supplemental Figure 3
Supplementary Figure 3 from Cisplatin Hypersensitivity of Testicular Germ Cell Tumors Is Determined by High Constitutive Noxa Levels Mediated by Oct-4
Authors: Gutekunst Matthias , Mueller Thomas , Weilbacher Andrea , Dengler Michael A. , Bedke Jens , Kruck Stephan , Oren Moshe , Aulitzky Walter E. , van der Kuip Heiko
Published: April 2023

PDF file - 20K, Constitutive Noxa mRNA levels are maintained via Oct-4-dependent transcriptional mechanisms
Supplementary Table 3 from Thyroid Hormone Regulation of miR-21 Enhances Migration and Invasion of Hepatoma
Authors: Huang Ya-Hui , Lin Yang-Hsiang , Chi Hsiang-Cheng , Liao Chen-Hsin , Liao Chia-Jung , Wu Sheng-Ming , Chen Cheng-Yi , Tseng Yi-Hsin , Tsai Chung-Ying , Lin Sheng-Yen , Hung Yu-Ting , Wang Chih-Jen , Lin Crystal D. , Lin Kwang-Huei
Published: April 2023

PDF - 55K, Expression of TR�1, miR-21 and TIAM1 from 40 patients with Hepatoma.
Supplementary Figure Legends from Tumor Endothelial Markers Define Novel Subsets of Cancer-Specific Circulating Endothelial Cells Associated with Antitumor Efficacy
Authors: Mehran Reza , Nilsson Monique , Khajavi Mehrdad , Du Zhiqiang , Cascone Tina , Wu Hua Kang , Cortes Andrea , Xu Li , Zurita Amado , Schier Robert , Riedel Bernhard , El-Zein Randa , Heymach John V.
Published: April 2023

PDF file - 59KB
Supplementary Figure 3 from Tumor Endothelial Markers Define Novel Subsets of Cancer-Specific Circulating Endothelial Cells Associated with Antitumor Efficacy
Authors: Mehran Reza , Nilsson Monique , Khajavi Mehrdad , Du Zhiqiang , Cascone Tina , Wu Hua Kang , Cortes Andrea , Xu Li , Zurita Amado , Schier Robert , Riedel Bernhard , El-Zein Randa , Heymach John V.
Published: April 2023

PDF file - 40KB, CECs and CEPs in peripheral blood of normal and tumor-bearing mice were evaluated using flow cytometry. CTECs were first identified based on the staining pattern of CECs and further characterized using CD276 and TEM7 antibodies. (A) Percentage of CECs positive for CD276. (B) Percentage of CECs positive for TEM7. * p<0.05.
Supplementary Figure 7 from Thyroid Hormone Regulation of miR-21 Enhances Migration and Invasion of Hepatoma
Authors: Huang Ya-Hui , Lin Yang-Hsiang , Chi Hsiang-Cheng , Liao Chen-Hsin , Liao Chia-Jung , Wu Sheng-Ming , Chen Cheng-Yi , Tseng Yi-Hsin , Tsai Chung-Ying , Lin Sheng-Yen , Hung Yu-Ting , Wang Chih-Jen , Lin Crystal D. , Lin Kwang-Huei
Published: April 2023

PDF - 655K, The effects of T3, miR-21 and TIAM1 in SK-Hep1 cells.
Supplementary Figure 1 from Tumor Endothelial Markers Define Novel Subsets of Cancer-Specific Circulating Endothelial Cells Associated with Antitumor Efficacy
Authors: Mehran Reza , Nilsson Monique , Khajavi Mehrdad , Du Zhiqiang , Cascone Tina , Wu Hua Kang , Cortes Andrea , Xu Li , Zurita Amado , Schier Robert , Riedel Bernhard , El-Zein Randa , Heymach John V.
Published: April 2023

PDF file - 104KB, Quantitative analysis of CTEC and CEC/CEP populations in mouse specimens by flow cytometry. Syto16 (DNA) gate used to exclude apoptotic, necrotic debris and cellular degraded fragments. CECs were characterized as CD31+CD45-VEGFR-2+CD117-, and CEPs as CD31+CD45-VEGFR-2+CD117+. Gating of CD276+ (top) and TEM7+ (bottom) CTECs from a representative animal specimen is shown.
Supplementary Data 5 from Epithelial-to-Mesenchymal Transition and Autophagy Induction in Breast Carcinoma Promote Escape from T-cell–Mediated Lysis
Authors: Akalay Intissar , Janji Bassam , Hasmim Meriem , Noman Muhammad Zaeem , André Fabrice , De Cremoux Patricia , Bertheau Philippe , Badoual Cécile , Vielh Philippe , Larsen Annette K. , Sabbah Michèle , Tan Tuan Zea , Keira Joan Herr , Ying Hung Nicole Tsang , Thiery Jean Paul , Mami-Chouaib Fathia , Chouaib Salem
Published: April 2023

PDF file - 10396K, Human breast cancer biopsies were stained for SNAI2 and LC3B expression by immunohistochemistry on serial tumor sections
Supplementary Figure 3 from Thyroid Hormone Regulation of miR-21 Enhances Migration and Invasion of Hepatoma
Authors: Huang Ya-Hui , Lin Yang-Hsiang , Chi Hsiang-Cheng , Liao Chen-Hsin , Liao Chia-Jung , Wu Sheng-Ming , Chen Cheng-Yi , Tseng Yi-Hsin , Tsai Chung-Ying , Lin Sheng-Yen , Hung Yu-Ting , Wang Chih-Jen , Lin Crystal D. , Lin Kwang-Huei
Published: April 2023

PDF File - 97K, Homo sapiens microRNA pri-miR-21, complete sequence.
Supplementary Data 2 from Epithelial-to-Mesenchymal Transition and Autophagy Induction in Breast Carcinoma Promote Escape from T-cell–Mediated Lysis
Authors: Akalay Intissar , Janji Bassam , Hasmim Meriem , Noman Muhammad Zaeem , André Fabrice , De Cremoux Patricia , Bertheau Philippe , Badoual Cécile , Vielh Philippe , Larsen Annette K. , Sabbah Michèle , Tan Tuan Zea , Keira Joan Herr , Ying Hung Nicole Tsang , Thiery Jean Paul , Mami-Chouaib Fathia , Chouaib Salem
Published: April 2023

PDF file - 72K, SNAI1-6SA cells were sorted by flow cytometry (MoFlo� Astrios� - Beckman Coulter, Inc) based on their ALDH activity
Supplementary Data 1 from Epithelial-to-Mesenchymal Transition and Autophagy Induction in Breast Carcinoma Promote Escape from T-cell–Mediated Lysis
Authors: Akalay Intissar , Janji Bassam , Hasmim Meriem , Noman Muhammad Zaeem , André Fabrice , De Cremoux Patricia , Bertheau Philippe , Badoual Cécile , Vielh Philippe , Larsen Annette K. , Sabbah Michèle , Tan Tuan Zea , Keira Joan Herr , Ying Hung Nicole Tsang , Thiery Jean Paul , Mami-Chouaib Fathia , Chouaib Salem
Published: April 2023

PDF file - 204K, Cancer stem cell properties of EMTed and autophagic cell lines
Supplementary Video 1 from Oncolytic Vaccinia Virus Disrupts Tumor-Associated Vasculature in Humans
Authors: Breitbach Caroline J. , Arulanandam Rozanne , De Silva Naomi , Thorne Steve H. , Patt Richard , Daneshmand Manijeh , Moon Anne , Ilkow Carolina , Burke James , Hwang Tae-Ho , Heo Jeong , Cho Mong , Chen Hannah , Angarita Fernando A. , Addison Christina , McCart J. Andrea , Bell John C. , Kirn David H.
Published: April 2023

Supplementary Video 1 MPG file - 708K, 3-dimensional tumor model of 10 cm HCC tumor depicted in Fig. 4a (baseline; prior to JX-594 treatment). Beige = perfused; green = hypoperfused; red = necrotic
Supplementary Figures 1 - 6 from The Insulin Receptor Negatively Regulates the Action of Pseudomonas Toxin-Based Immunotoxins and Native Pseudomonas Toxin
Authors: Liu Xiu Fen , FitzGerald David J. , Pastan Ira
Published: April 2023

PDF file - 697K, siRNA siIR-�2, which does not knock down IR expression, did not affect SS1P toxicity (S1); Treatment by IT reduced IR protein levels (S2); LRP1B is expressed in KB31 cells (S3); SS1P internalization was not enhanced in KB31 cells after IR knock down (S4); Inhibitors of the IR signal pathway did not affect SS1P induced toxicity (S5); IR-A and IR-B isoform expression in cell lines (S6).
Supplementary Figure 3 from Oncolytic Vaccinia Virus Disrupts Tumor-Associated Vasculature in Humans
Authors: Breitbach Caroline J. , Arulanandam Rozanne , De Silva Naomi , Thorne Steve H. , Patt Richard , Daneshmand Manijeh , Moon Anne , Ilkow Carolina , Burke James , Hwang Tae-Ho , Heo Jeong , Cho Mong , Chen Hannah , Angarita Fernando A. , Addison Christina , McCart J. Andrea , Bell John C. , Kirn David H.
Published: April 2023

Supplementary Figure 3 PDF file - 83K, Normal fibroblasts (GM38 cells) do not express VEGFR2 and are not sensitized to JX-594 infection upon incubation with VEGF
Supplementary Figure 2 from Oncolytic Vaccinia Virus Disrupts Tumor-Associated Vasculature in Humans
Authors: Breitbach Caroline J. , Arulanandam Rozanne , De Silva Naomi , Thorne Steve H. , Patt Richard , Daneshmand Manijeh , Moon Anne , Ilkow Carolina , Burke James , Hwang Tae-Ho , Heo Jeong , Cho Mong , Chen Hannah , Angarita Fernando A. , Addison Christina , McCart J. Andrea , Bell John C. , Kirn David H.
Published: April 2023

Supplementary Figure 2 PDF file - 144K, Bevacizumab reduces TK1 levels & blocks VEGF-mediated JX-594 sensitization in HUVECs, demonstrated by decreased transgene expression (GFP) and decreased burst size
Supplementary Figure S6 from Adjuvants That Improve the Ratio of Antigen-Specific Effector to Regulatory T Cells Enhance Tumor Immunity
Authors: Perret Rachel , Sierro Sophie R. , Botelho Natalia K. , Corgnac Stéphanie , Donda Alena , Romero Pedro
Published: April 2023

Supplementary Figure S6. Early cytokine production by APC in the vaccine draining lymph nodes
Supplementary Figure S6 from A Multifunctional Chimeric Chaperone Serves as a Novel Immune Modulator Inducing Therapeutic Antitumor Immunity
Authors: Yu Xiaofei , Guo Chunqing , Yi Huanfa , Qian Jie , Fisher Paul B. , Subjeck John R. , Wang Xiang-Yang
Published: April 2023

Supplementary Figure S6 PDF file - 53K, Ad.Flagrp170 therapy of TRAMP-C2 prostate tumor and CT-26 tumor induces a strong tumor- or antigen-reactive immune response
Supplementary Figure S5 from A Multifunctional Chimeric Chaperone Serves as a Novel Immune Modulator Inducing Therapeutic Antitumor Immunity
Authors: Yu Xiaofei , Guo Chunqing , Yi Huanfa , Qian Jie , Fisher Paul B. , Subjeck John R. , Wang Xiang-Yang
Published: April 2023

Supplementary Figure S5 PDF file - 145K, A . Recruitment of CD8+CD11c+ and CD11b+F4/80+ cells to the tumor sites following Ad.Flagrp170 therapy. B16 tumor-bearing mice were treated with indicated adenoviruses, and cell infiltration was analyzed using FACS by gating on tumor infiltrating leukocytes. B. IL-12p70 production in tumor-infiltrating myeloid cells was measured using intracellular cytokine staining assays. CD11c+ cells are not the major source of IL-12 (n=3, representative of 3 independent experiments). C. Flow cytometry analysis of splenic CD11c+ cells in DTx (8 ng/kg)-treated chimera mice reconstituted with BM from DTRtg mice
Supplementary Figure S3 from A Multifunctional Chimeric Chaperone Serves as a Novel Immune Modulator Inducing Therapeutic Antitumor Immunity
Authors: Yu Xiaofei , Guo Chunqing , Yi Huanfa , Qian Jie , Fisher Paul B. , Subjeck John R. , Wang Xiang-Yang
Published: April 2023

Supplementary Figure S3 PDF file - 99K, Effects of Ad.Flagrp170 on B16 tumor cells
Supplementary Figure 1 from A Novel Inhibitor of STAT3 Homodimerization Selectively Suppresses STAT3 Activity and Malignant Transformation
Authors: Zhang Xiaolei , Sun Ying , Pireddu Roberta , Yang Hua , Urlam Murali K. , Lawrence Harshani R. , Guida Wayne C. , Lawrence Nicholas J. , Sebti Saïd M.
Published: April 2023

PDF file - 264K, Figure S1: STAT3-C rescues from S3I-1757 down regulation of STAT3-regulated genes and inhibition of proliferation/survival. MDA-MB-468 cells were transiently transfected with vector or STAT3C then were treated with S3I-1757 as described in Methods. The cells were then processed for western immuno-blotting (A) and for MTT assays (B) as described in Methods.
Supplementary Table 4 from Loss of the Polycomb Mark from Bivalent Promoters Leads to Activation of Cancer-Promoting Genes in Colorectal Tumors
Authors: Hahn Maria A. , Li Arthur X. , Wu Xiwei , Yang Richard , Drew David A. , Rosenberg Daniel W. , Pfeifer Gerd P.
Published: April 2023

PDF file - 29KB, Annotation of genes which do not belong to crypt top or bottom specific transcriptomes, activated in all tumors and having bivalent promoters in at least in 3 out of 4 mucosa samples.
Supplementary Table 3 from Loss of the Polycomb Mark from Bivalent Promoters Leads to Activation of Cancer-Promoting Genes in Colorectal Tumors
Authors: Hahn Maria A. , Li Arthur X. , Wu Xiwei , Yang Richard , Drew David A. , Rosenberg Daniel W. , Pfeifer Gerd P.
Published: April 2023

PDF file - 41KB, Top 10 molecular and cellular functions of bivalent genes, which become activated in colon tumors.
Supplementary Figure 9 from Acidity Generated by the Tumor Microenvironment Drives Local Invasion
Authors: Estrella Veronica , Chen Tingan , Lloyd Mark , Wojtkowiak Jonathan , Cornnell Heather H. , Ibrahim-Hashim Arig , Bailey Kate , Balagurunathan Yoganand , Rothberg Jennifer M. , Sloane Bonnie F. , Johnson Joseph , Gatenby Robert A. , Gillies Robert J.
Published: April 2023

PDF file - 658K, Figure S9: In vitro degradation of collagen I and IV by HCT116 cells. A) Images show 2-day cultures of HCT116 cells grown in 2D collagen I and 3D rBM overlay cultures at pHe 7.4 and 6.8, respectively. Images represent degradation products of DQ-collagen I and DQ-collagen IV in the entire 2D and 3D volume of cells. B) Using the Definiens imaging software, proteolytic activity was measured, correlated to fluorescence intensity and normalized to cell area. Proteolytic activity at acidic pHe was statistically significant (p<0.0051 for DQ 1 and p<0.03 for DQ IV).
Supplementary Figure 8 from Acidity Generated by the Tumor Microenvironment Drives Local Invasion
Authors: Estrella Veronica , Chen Tingan , Lloyd Mark , Wojtkowiak Jonathan , Cornnell Heather H. , Ibrahim-Hashim Arig , Bailey Kate , Balagurunathan Yoganand , Rothberg Jennifer M. , Sloane Bonnie F. , Johnson Joseph , Gatenby Robert A. , Gillies Robert J.
Published: April 2023

PDF file - 45K, Figure S8: In vivo relation between vessel density and tumor growth. The data from Figure S5 were used to compare tumor growth (change in number of pixels from day 4 to day 13) to vessel density (on day 4) in each of the 4 quadrants.
Supplementary Figure 7 from Acidity Generated by the Tumor Microenvironment Drives Local Invasion
Authors: Estrella Veronica , Chen Tingan , Lloyd Mark , Wojtkowiak Jonathan , Cornnell Heather H. , Ibrahim-Hashim Arig , Bailey Kate , Balagurunathan Yoganand , Rothberg Jennifer M. , Sloane Bonnie F. , Johnson Joseph , Gatenby Robert A. , Gillies Robert J.
Published: April 2023

PDF file - 241K, Figure S7: Segmentation and analysis of vasculature In vivo. In vivo vessels and tumors were independently segmented and quantified within four ordinal quadrants emanating from the tumor centroid as described in Methods.
Supplementary Figures 1 - 6 from Loss of the Polycomb Mark from Bivalent Promoters Leads to Activation of Cancer-Promoting Genes in Colorectal Tumors
Authors: Hahn Maria A. , Li Arthur X. , Wu Xiwei , Yang Richard , Drew David A. , Rosenberg Daniel W. , Pfeifer Gerd P.
Published: April 2023

PDF file - 816KB, Confirmation of CpG island hypermethylation patterns by COBRA DNA methylation analysis (S1). Reproducibility of chromatin immunoprecipitation from frozen human tissue samples (S2). Loss of H3K27me3 in colorectal cancer and mutually exclusive gain of 5mC or H3K4me3 (S3). Bivalent genes in human colonic mucosa (S4). H3K27me3 patterns in human colonic mucosa and aberrant DNA methylation in colorectal cancer (S5). Cancer-associated transcriptional changes at bivalent promoters (S6).
Supplementary Figure 4 from Acidity Generated by the Tumor Microenvironment Drives Local Invasion
Authors: Estrella Veronica , Chen Tingan , Lloyd Mark , Wojtkowiak Jonathan , Cornnell Heather H. , Ibrahim-Hashim Arig , Bailey Kate , Balagurunathan Yoganand , Rothberg Jennifer M. , Sloane Bonnie F. , Johnson Joseph , Gatenby Robert A. , Gillies Robert J.
Published: April 2023

PDF file - 77K, Figure S4: Quantification of tumor growth. Images are shown for mouse tumor #23 on day 4 (green) and day 14 (red). Images were co-registered using the ring clip of the DWC as a fiducial. The centroid of the tumor on day 4 was calculated and radial lines were drawn every 22.5o of arc, beginning at the ring. Growth was calculated as the number of pixels that the day 14 tumor extended beyond the edge of the day 4 tumor using Definiens Developer XD�.
Supplementary Figure 2 from Acidity Generated by the Tumor Microenvironment Drives Local Invasion
Authors: Estrella Veronica , Chen Tingan , Lloyd Mark , Wojtkowiak Jonathan , Cornnell Heather H. , Ibrahim-Hashim Arig , Bailey Kate , Balagurunathan Yoganand , Rothberg Jennifer M. , Sloane Bonnie F. , Johnson Joseph , Gatenby Robert A. , Gillies Robert J.
Published: April 2023

PDF file - 45K, Figure S2: Comparison of normal vs tumor cells by size. Using these phase contrast images, ROI were chosen and area of cells was determined by pixel number using Image-Pro Plus v6.2. Once area was measured, data analysis revealed statistical significance (p<0.0001) between cell size.
Supplementary Figure 1 from Acidity Generated by the Tumor Microenvironment Drives Local Invasion
Authors: Estrella Veronica , Chen Tingan , Lloyd Mark , Wojtkowiak Jonathan , Cornnell Heather H. , Ibrahim-Hashim Arig , Bailey Kate , Balagurunathan Yoganand , Rothberg Jennifer M. , Sloane Bonnie F. , Johnson Joseph , Gatenby Robert A. , Gillies Robert J.
Published: April 2023

PDF file - 287K, Figure S1: Photomicrographs of cells in this study. HMEC, HCT116/GFP and MDAmb231 cells were grown to 70-80% confluency. Samples were then viewed with an automated Zeiss Observer Z.1 inverted microscope through a 10x /0.3NA or 20x/0.4NA objective and a phase contrast ring. Images were produced using the AxioCam MRm CCD camera and Axiovision version 4.6 software suite. (Carl Zeiss Inc., Germany).
Supplementary Movie 1 from Integrin-Free Tetraspanin CD151 Can Inhibit Tumor Cell Motility upon Clustering and Is a Clinical Indicator of Prostate Cancer Progression
Authors: Palmer Trenis D. , Martínez Carlos H. , Vasquez Catalina , Hebron Katie E. , Jones-Paris Celestial , Arnold Shanna A. , Chan Susanne M. , Chalasani Venu , Gomez-Lemus Jose A. , Williams Andrew K. , Chin Joseph L. , Giannico Giovanna A. , Ketova Tatiana , Lewis John D. , Zijlstra Andries
Published: April 2023

MOV - 8452K, CD151 clustering at areas of cell-cell contact in HEp3 tumor cells.
Supplementary Figure 2 from SRC Signaling Is Crucial in the Growth of Synovial Sarcoma Cells
Authors: Michels Sebastian , Trautmann Marcel , Sievers Elisabeth , Kindler Dagmar , Huss Sebastian , Renner Marcus , Friedrichs Nicolaus , Kirfel Jutta , Steiner Susanne , Endl Elmar , Wurst Peter , Heukamp Lukas , Penzel Roland , Larsson Olle , Kawai Akira , Tanaka Shinya , Sonobe Hiroshi , Schirmacher Peter , Mechtersheimer Gunhild , Wardelmann Eva , Büttner Reinhard , Hartmann Wolfgang
Published: April 2023

PDF file - 57K, Significant decrease of p-(Tyr416)-SRC levels upon siRNA-mediated knockdown of IGF-1R in CME-1 synovial sarcoma cells.
Supplementary Figures 1 through 8 from Integrin-Free Tetraspanin CD151 Can Inhibit Tumor Cell Motility upon Clustering and Is a Clinical Indicator of Prostate Cancer Progression
Authors: Palmer Trenis D. , Martínez Carlos H. , Vasquez Catalina , Hebron Katie E. , Jones-Paris Celestial , Arnold Shanna A. , Chan Susanne M. , Chalasani Venu , Gomez-Lemus Jose A. , Williams Andrew K. , Chin Joseph L. , Giannico Giovanna A. , Ketova Tatiana , Lewis John D. , Zijlstra Andries
Published: April 2023

PDF - 5142K, CD151 clustering at areas of cell-cell contact in vivo (S1); Cell-cell adhesion in response to CD151 clustering (S2); MAB 1A5 binds to CD151 not engaged with α3 integrin in HEp3 cells (S3); MAb 1A5 recognizes the integrin-binding domain of CD151 (S4); Antibodies that recognize the integrin-binding domain of CD151 mediate clustering at areas of cell-cell contact (S5); CD151 expression in normal and prostate cancer tissue (S6); Expression of integrin α3 is not altered in cancers of the bladder or skin (S7); CD151free detectable in benign and normal prostate tissue does not correspond with patient outcome (S8).
Supplementary Figure Legend from Identification of Inherited Genetic Variations Influencing Prognosis in Early-Onset Breast Cancer
Authors: Rafiq Sajjad , Tapper William , Collins Andrew , Khan Sofia , Politopoulos Ioannis , Gerty Sue , Blomqvist Carl , Couch Fergus J. , Nevanlinna Heli , Liu Jianjun , Eccles Diana
Published: April 2023

PDF file - 45K
Supplementary Figure 5 from Identification of Inherited Genetic Variations Influencing Prognosis in Early-Onset Breast Cancer
Authors: Rafiq Sajjad , Tapper William , Collins Andrew , Khan Sofia , Politopoulos Ioannis , Gerty Sue , Blomqvist Carl , Couch Fergus J. , Nevanlinna Heli , Liu Jianjun , Eccles Diana
Published: April 2023

PDF file - 54K, Regional plot of p-values arising from cox-proportional hazard models, 250 kb either side of the rs1387389 variant in stage-1. P-values are from imputed data alone.
Supplementary Figure S5 from IFN-γ–Mediated Downregulation of LXA4 Is Necessary for the Maintenance of Nonresolving Inflammation and Papilloma Persistence
Authors: Wang Chunhui , Xiao Mingjie , Liu Xiaoman , Ni Chen , Liu Jianhong , Erben Ulrike , Qin Zhihai
Published: April 2023

Supplementary Figure S5 PDF file - 1938K, The efficacy of LXA4 in inflammation resolution and papilloma regression process was blocked by BOC2 and mimicked by 15-epi-LXA4
Supplementary Figure 1 from Identification of Inherited Genetic Variations Influencing Prognosis in Early-Onset Breast Cancer
Authors: Rafiq Sajjad , Tapper William , Collins Andrew , Khan Sofia , Politopoulos Ioannis , Gerty Sue , Blomqvist Carl , Couch Fergus J. , Nevanlinna Heli , Liu Jianjun , Eccles Diana
Published: April 2023

PDF file - 36K, Principal Components of whole genome data from the POSH study. The plot shows first two principal component based on post quality control genome wide data.
Supplementary Figure S2 from IFN-γ–Mediated Downregulation of LXA4 Is Necessary for the Maintenance of Nonresolving Inflammation and Papilloma Persistence
Authors: Wang Chunhui , Xiao Mingjie , Liu Xiaoman , Ni Chen , Liu Jianhong , Erben Ulrike , Qin Zhihai
Published: April 2023

Supplementary Figure S2 PDF file - 1057K, BOC2 did not influence the LXA4 level in mice with 8-week anti-IFN� treatment
Supplementary Figure Legend from Inhibition of CSF-1 Receptor Improves the Antitumor Efficacy of Adoptive Cell Transfer Immunotherapy
Authors: Mok Stephen , Koya Richard C. , Tsui Christopher , Xu Jingying , Robert Lídia , Wu Lily , Graeber Thomas G. , West Brian L. , Bollag Gideon , Ribas Antoni
Published: April 2023

PDF file - 60K
Supplementary Table 7 from Comparative Oncogenomics Identifies PSMB4 and SHMT2 as Potential Cancer Driver Genes
Authors: Lee Genee Y. , Haverty Peter M. , Li Li , Kljavin Noelyn M. , Bourgon Richard , Lee James , Stern Howard , Modrusan Zora , Seshagiri Somasekar , Zhang Zemin , Davis David , Stokoe David , Settleman Jeffrey , de Sauvage Frederic J. , Neve Richard M.
Published: April 2023

XLSX file - 37K, Supplementary materials and methods (cell lines, STR profiles, primers, antibodies, molecular reagents).
Supplementary Table 2 from Inherited Variation in miR-290 Expression Suppresses Breast Cancer Progression by Targeting the Metastasis Susceptibility Gene Arid4b
Authors: Goldberger Natalie , Walker Renard C. , Kim Chang Hee , Winter Scott , Hunter Kent W.
Published: April 2023

PDF file - 48K, The expression levels of miR-290-3p and miR-290-5p were evaluated via qRT-PCR in the 6dt1 and Mvt-1 cell lines generated.
Supplementary Table 1 from Inherited Variation in miR-290 Expression Suppresses Breast Cancer Progression by Targeting the Metastasis Susceptibility Gene Arid4b
Authors: Goldberger Natalie , Walker Renard C. , Kim Chang Hee , Winter Scott , Hunter Kent W.
Published: April 2023

PDF file - 63K, The top differentially expressed genes based on fold change (FC) in the 6dt1 miR-290 tumors.