bluuebunny/crossref_metadata_2025 huggingface dataset:
N-(((1S,5R)-6,6-Dimethylbicyclo[3.1.1]hept-2-en-2-yl)methyl)-3-dodecan/tetradecanamido-N,N-dimethylpropan-1-aminium Bromide
Authors: Nikitina Liliya E. , Gilfanov Ilmir R. , Pavelyev Roman S. , Lisovskaya Svetlana A. , Trizna Elena Y. , Rakhmatullin Ilfat Z. , Klochkov Vladimir V. , Davletshin Rustam R. , Babaeva Olga B. , Kolesnikova Alena I. , Ostolopovskaya Olga V. , Frolova Larisa L. , Kayumov Airat R.
Published: July 2023

The syntheses of the title compounds were performed using lauric and myristic acids. The compounds obtained were characterized using 1H-, 13C-NMR and 2D 1H-1H COSY, 1H-13C HSQC NMR, IR, and high-resolution mass spectrometry. Both compounds exhibited bactericidal activity on S. aureus comparable to that of a reference drug (miramistin). Compound 10, with lauric acid fragment, had a 16-fold higher activity on P. aeruginosa compared to compound 11, which in turn contains myristic acid fragment (with minimum inhibitory concentrations of 32 and 512 μg/mL, respectively). Compound 11 exhibited a pronounced activity against all types of fungi (higher than the activity of miramistin), while the activity of compound 10 was considerably lower. Thus, compound 11 can serve as a promising antimicrobial agent for the treatment of various fungal and staphylococcal infections, while compound 10 is of interest to treat P. aeruginosa-associated infections.
Photocatalytic Degradation of Xylene by Carbon Quantum Dots/Clinoptilolite Composites
Authors: Zhu Shuguang , Cheng Chun , Meng Li , Zhang Pengyu , Sun Bai
Published: July 2023

In this work, a series of clinoptilolite composites decorated with carbon quantum dots (CQDs/clinoptilolite) with hierarchical pore structures was demonstrated that exhibits good photocatalytic performance for the removal of xylene. The technique for the attachment of carbon quantum dots to clinoptilolite was prepared by a hydrothermal method in this study. The structural features were confirmed by SEM, TEM, EDS, XRD, BET, XPS, and solid diffuse reflection measurements, while the degradation mechanism was investigated by adding a trapping agent into the nanocomposites. The introduction of CQDs promoted the separation of photogenerated electrons and holes as well as the generation of reactive radicals, which effectively improved the light utilization and even increased the degradation rate of xylene by 73% at the optimal state. The photocatalytic test was conducted under a different dwell time, catalyst dosage, initial concentration, and illumination intensity. The results showed that the degradation rate of xylene by the CQDs/clinoptilolite catalyst reached 97.4% under the optimal reaction conditions (the catalyst was Catalyst No. 2, the residence time was 90 s, the initial concentration was 2.5 g/m3, the light intensity was three lamps for irradiation, and the catalyst dosage was 0.05 g). In addition, the degradation efficiency of the CQDs/clinoptilolite photocatalyst still reached 78% after eight consecutive catalytic regeneration cycles. This work sheds new light on the degradation of xylene.
Development of Electrodeposited Wire Mesh Grinding Wheel for Cutoff and Grooving Carbon Fiber Reinforced Plastic
Authors: Nomura Mamoru , Kurashige Shuji , Ito Yukio , Fukuhara Yoshiya , Sasahara Hiroyuki
Published: July 2023

Carbon fiber reinforced plastic (CFRP) is used in various industries because of its high specific strength, but it is well known as a difficult material to cut. In this study, we developed a disc-shaped electrodeposited diamond wire mesh grinding wheel as a new method for cutoff and grooving with a large aspect ratio for CFRP. We confirmed that this tool could be used for machining at a feed rate of 1000 mm/min, equivalent to that of an abrasive waterjet. This tool discharges generated chips through the spaces in the wire mesh, preventing clogging and thereby enabling the suppression of machining temperature. No burrs or delamination were observed on the surface machined with the wire mesh grinding wheel, and the surface roughness was Ra = 2.76 µm. However, the groove width was larger than the wheel thickness due to the runout of the wheel. Additionally, the moderate elasticity and durability of the tool suggest that it might extend tool life by avoiding the crushing of abrasive grains.
Enhancing the Performance of Organic Phototransistors Based on Oriented Floating Films of P3HT Assisted by Al-Island Deposition
Authors: Lahane Tejswini K. , Sharma Shubham , Desu Moulika , Ando Yoshito , Pandey Shyam S. , Singh Vipul
Published: July 2023

The fabrication of high-performance Organic Phototransistors (OPTs) by depositing Al-islands atop Poly(3-hexylthiophene) (P3HT) thin film coated using the unidirectional floating-film transfer method (UFTM) has been realized. Further, the effect of Al-island thickness on the OPTs’ performance has been intensively investigated using X-ray photoelectron spectroscopy, X-ray Diffraction, Atomic force microscopy and UV-Vis spectroscopy analysis. Under the optimized conditions, OPTs’ mobility and on–off ratio were found to be 2 × 10−2 cm2 V−1 s−1 and 3 × 104, respectively. Further, the device exhibited high photosensitivity of 105, responsivity of 339 A/W, detectivity of 3 × 1014 Jones, and external quantum efficiency of 7.8 × 103% when illuminated with a 525 nm LED laser (0.3 mW/cm2).
Effect of Thermal Aging on the Interfacial Reaction Behavior and Failure Mechanism of Ni-xCu/Sn Soldering Joints under Shear Loading
Authors: Li Zhigang , Cheng Kai , Liu Jiajun , He Yigang , Xiao Yong
Published: July 2023

Ni-xCu/Sn soldering joints were aged at 200 °C, and the microstructure evolution and mechanical properties during the solid-state reaction were studied under shear loading. Results showed that the intermetallic compounds (IMCs) exhibited a Cu content-dependent transformation from the (Ni,Cu)3Sn4 phase to the (Cu,Ni)6Sn5 phase at the Ni-xCu/Sn interface. Furthermore, a Cu3Sn layer was observed exclusively at the Cu/Sn interface. The shear strength of the soldering joints after thermal aging exhibited an initial decrease followed by an increase, except for a significant enhancement at the Cu content of 60 wt.%. In addition, the evolution law of mechanical properties and failure mechanism of the thermal aging joints were elucidated based on the fracture microstructure and the fracture curve of the joints.
The Removal of Inclusions with Different Diameters in Tundish by Channel Induction Heating: A Numerical Simulation Study
Authors: Yi Bing , Zhang Guifang , Jiang Qi , Zhang Peipei , Feng Zhenhua , Tian Nan
Published: July 2023

The quality of the bloom will be impacted by the non-metallic impurities in the molten steel in the tundish, which will reduce the plasticity and fatigue life of the steel. In this research, a mathematical model of a six-flow double-channel T-shaped induction heating tundish was established, the effects of induction heating conditions on the removal of inclusions in the tundish were investigated, and the impact of various inclusion particle sizes on the removal effect of inclusions under induction heating was explored. The results show that the Residence Time Distribution (RTD) curve produced through numerical simulation and physical simulation is in good agreement. The reduction of inclusion particles in the channel is made affordable by the dual-channel induction heating technique. As the diameter of inclusion particles increases from 10 μm to 50 μm, the probability of inclusion particles being removed from the channel gradually decreases from 70.9% to 56.1%.
Dependences of Magnetic Properties on the Grain Size and Hard/Soft Magnetic Phase Volume Ratio for Ce2Fe14B/α-Fe and Nd2Fe14B/α-Fe Nanocomposites
Authors: Liu Xiangyi , Zhou Bang , Yuan Bin , Liu Zhongwu
Published: July 2023

The magnetic properties of magnetic nanocomposites consisting of hard and soft magnetic phases are dependent not only on the intrinsic properties but also on the grain structure and volume ratio of the two phases. In this study, we performed a systematic micromagnetic simulation on the magnetic properties of Ce2Fe14B/α-Fe and Nd2Fe14B/α-Fe nanocomposites. The volume fractions of the hard magnetic Nd2Fe14B or Ce2Fe14B phase were varied from 80% to 40%, and the grain sizes of the hard magnetic phase and the soft magnetic α-Fe phase were changed independently from 10 nm to 40 nm. The results show that when the grain size of both hard and soft phases is 10 nm and the volume fraction of the hard phase is 70%, the highest maximum magnetic energy product can be obtained in both Ce2Fe14B/α-Fe and Nd2Fe14B/α-Fe nanocomposites. The hard magnetic properties of Ce2Fe14B/α-Fe nanocomposite decrease significantly when the volume fraction of the α-Fe phase exceeds 30%. However, for the Nd2Fe14B/α-Fe system, this situation only occurs when the α-Fe volume fraction exceeds 40%. The reason for this is not only because of the low anisotropic field and the smaller exchange coupling length between the soft and hard magnetic phases, but also because of the lower saturation magnetization of the hard phase. The grain size has greater effects on the magnetic properties compared to the volume fraction of the hard magnetic phase. The main reason is that as the grain size increases, the remanence of the nanocomposite decreases sharply, which also leads to a rapid decrease in the maximum magnetic energy product. The simulation results on the effects of phase ratio and grain size have been verified by experiments on melt-spun Ce2Fe14B/α-Fe alloys with various compositions prepared by melt-spinning followed by annealing for various lengths of time. Due to the influence of demagnetization energy, the hard magnetic phase with high saturation magnetization is preferred for the preparation of high-performance nanocomposite magnets.
Preparation of Al3Ti-Al2O3/Al Inoculant and Its Inoculation Effect on Al-Cu-Mn Alloy
Authors: Ding Jinhua , Wang Chao , Lu Cheng , Zhu Guangming , Guo Nana , Gao Xujie , Wang Xin , Cui Chunxiang
Published: July 2023

The grain size plays a pivotal role in determining the properties of the alloy. The grain size can be significantly decreased by adding inoculants. Aiming to address the shortcomings of existing inoculants, the Al3Ti-Al2O3/Al inoculant was successfully prepared using Al-Ti master alloy and Al2O3 whiskers as raw materials. With the aid of ultrasonic energy, the Al2O3 whiskers were uniformly dispersed within the inoculants. Under the combined action of ultrasonic and titanium, the Al2O3 whiskers were broken into small particles at high temperature. To enhance the morphology of Al3Ti and achieve even particle dispersion throughout the matrix, vacuum rapid quenching treatment was applied to the inoculant. The SEM test results indicated a significant reduction in particle size after vacuum rapid quenching. The Al3Ti-Al2O3/Al inoculants exhibited excellent grain refinement effects on the weldable Al-Cu-Mn alloy. Crystallographic calculations and HRTEM analysis revealed that Al2O3 and Al have orientation relationships, indicating their potential as effective heterogeneous nucleation sites. The mechanical properties of the Al-Cu-Mn alloy were obviously improved after the Al3Ti-Al2O3/Al inoculant was added.
The Effect of Secondary Aluminum Ash on the Properties of Reactive Powder Concrete
Authors: Xu Wenyu , Wang Hui , Tian Xiaoning
Published: July 2023

Secondary aluminum ash is a kind of common solid waste which will pollute the environment without any treatment. In this study, the influence of secondary aluminum ash on the rheological properties and the initial setting time of fresh reactive powder concrete (RPC) are researched. Meanwhile, the mechanical properties and the drying shrinkage rates of RPC with the secondary aluminum ash are determined. The electrical parameters of RPC with the secondary aluminum ash are measured. Scanning electron microscopy is obtained to reflect the internal structure of RPC. Results show that the addition of secondary aluminum ash can lead to decreasing the fluidity and increase the yield shear stress of fresh RPC paste by varying rates of 16.1% and 58.3%, respectively. The addition of secondary aluminum ash can decrease the flexural and compressive strengths of RPC cured for 1 day by the decreasing rates of 0~18.7% and 0~19.3%. When the curing age is 28 days, the flexural and compressive strengths of RPC are increased by 0~9.1% and 0~19.1% with adding the secondary aluminum ash. The secondary aluminum ash can promote the condensation of RPC. The addition of the secondary aluminum ash can decrease the electrical resistance of RPC by an order of magnitude. The relationship between the electrical resistance and the electrical reactance fits the quadratic function equation. The electrical resistance of the pore solution increases in the form of a quadratic function with the mass ratio of the secondary aluminum ash. The dry shrinkage rates of RPC cured for 1 day and 28 days are decreased by 0~36.4% and 0~41.3% with the increasing dosages of secondary aluminum ash. As obtained from the microscopic testing results, the secondary aluminum ash can improve the compactness of hydration products.
Identification and Classification of Multi-Attribute Decision-Making Based on Complex Intuitionistic Fuzzy Frank Aggregation Operators
Authors: Yang Xiaopeng , Mahmood Tahir , Ali Zeeshan , Hayat Khizar
Published: July 2023

Invented by Frank in 1979, Frank’s t-norm and t-conorm operations possess improved modifications and can be applied more generally than the existing algebraic t-norm and t-conorm. The major objective of this article is to determine Frank’s operational laws based on complex intuitionistic fuzzy (CIF) information. Moreover, we examine the Frank aggregation operators (averaging and geometric) based on CIF set theory and Frank operational laws, such as the CIF Frank weighted averaging (CIFFWA) operator, CIF Frank ordered weighted averaging (CIFFOWA) operator, CIF Frank hybrid averaging (CIFFHA) operator, CIF Frank weighted geometric (CIFFWG) operator, CIF Frank ordered weighted geometric (CIFFOWG) operator and CIF Frank hybrid geometric (CIFFHG) operator. Some dominant and feasible properties of the invented techniques are also stated. Additionally, to evaluate the problem of osteoporosis in human bodies based on their causes and risk factors, we illustrate an application of the multi-attribute decision-making (MADM) technique with consideration of the invented methods to show the supremacy and validity of the derived techniques. Finally, we aim to compare the proposed scenarios with some valid existing or prevailing techniques to increase the value of the presented approaches.
A Model in Which Well-Orderings of the Reals First Appear at a Given Projective Level, Part III—The Case of Second-Order PA
Authors: Kanovei Vladimir , Lyubetsky Vassily
Published: July 2023

A model of set theory ZFC is defined in our recent research, in which, for a given n≥3, (An) there exists a good lightface Δn1 well-ordering of the reals, but (Bn) no well-orderings of the reals (not necessarily good) exist in the previous class Δn−11. Therefore, the conjunction (An)∧(Bn) is consistent, modulo the consistency of ZFC itself. In this paper, we significantly clarify and strengthen this result. We prove the consistency of the conjunction (An)∧(Bn) for any given n≥3 on the basis of the consistency of PA2, second-order Peano arithmetic, which is a much weaker assumption than the consistency of ZFC used in the earlier result. This is a new result that may lead to further progress in studies of the projective hierarchy.
Simultaneous Exact Controllability of Mean and Variance of an Insurance Policy
Authors: Rajaram Rajeev , Ritchey Nathan
Published: July 2023

We explore the simultaneous exact controllability of mean and variance of an insurance policy by utilizing the benefit St and premium Pt as control inputs to manage the policy value tV and the variance 2σt of future losses. The goal is to determine whether there exist control inputs that can steer the mean and variance from a prescribed initial state at t=0 to a prescribed final state at t=T, where the initial–terminal pair of states (0V,TV) and (2σ0,2σT) represent the mean and variance of future losses at times t=0 and t=T, respectively. The mean tV and variance 2σt are governed by Thiele’s and Hattendorff’s differential equations in continuous time and recursive equations in discrete time. Our study focuses on solving the problem of exact controllability in both continuous and discrete time. We show that our result can be used to devise control inputs St,Pt in the interval [0,T] so that the mean and variance partially track a specified curve tV=a(t) and 2σt=b(t), respectively, i.e., at a fine sampling of points in the time interval [0,T].
Evaluation of Blood Pressure Status and Mortality in Turkey: Findings from Chronic Diseases and Risk Factors Cohort Study
Authors: Sozmen Kaan , Ergor Gul , Sakarya Sibel , Dinc Horasan Gonul , Sahan Ceyda , Ekinci Banu , Arikan Ahmet , Sis Secil , Unal Belgin
Published: July 2023

Background and objectives: An important Non-Communicable Disease risk factor, hypertension (HT), is highly prevalent and controlled HT rates are not sufficient which increases the risk of developing premature deaths. The purpose of the study is to evaluate differences in all-cause and cardiovascular-related mortality according to HT status by using national data from Chronic Diseases and Risk Factors Survey in Turkey (2011–2017). Materials and Methods: Cox regression models were used to estimate hazard ratios (HR) for predicting the all-cause and cardiovascular system-related mortalities. Median follow-up period was 6.2 years. Results: Among individuals with HT, 41.8% was untreated, 30.1% received treatment and had controlled blood pressure, and 28.1% were under treatment but had uncontrolled BP levels. The hazard for mortality among treated & uncontrolled hypertensive participants was significantly higher for all-cause (HR = 1.32, 95% CI = 1.06–1.65), cardiovascular (HR = 2.11, 95% CI = 1.46–3.06), heart disease (HR = 2.24, 95% CI = 1.46–3.43), and Coronary Heart Disease mortality (HR = 2.66, 95% CI = 1.56–4.53) compared to normotensive participants. Conclusions: Individuals with HT who were treated but do not have controlled blood pressure in Turkey had a significantly increased risk of Cardiovascular Disease and all-cause mortality. Along with studies investigating the causes of uncontrolled blood pressure despite initiation of treatment, support should be provided to patients in cases of non-adherence to antihypertensive medication or life change recommendations.
Advances in Methodology for Fatigue Assessment of Composite Steel–Concrete Highway Bridges Based on the Vehicle–Bridge Dynamic Interaction and Pavement Deterioration Model
Authors: Soares da Silva Ana Célia , Alencar Guilherme Santana , Santos da Silva José Guilherme
Published: July 2023

Fatigue cracking is one of the most prominent causes of mechanical failure limiting the service life of existing steel and composite steel–concrete bridges and is among the central concerns of structural and bridge engineers. In this context, the current work presents some recent advancements in an existing methodology for fatigue analysis developed by the authors throughout the years. The methodology is specifically devoted to the fatigue assessment of composite steel–concrete bridges employing the local hot-spot S-N approach and a coupled vehicle–pavement–bridge system considering progressive pavement deterioration with stochastically generated roughness profiles. Two different methodologies were used to solve the dynamic equilibrium equations: the modal superposition method to solve the bridge dynamic equations and a direct integration method to solve the vehicle dynamic equations. From a computational point of view, the present approach is more efficient and detailed than previous versions, as it allows a significant reduction in the analysis time and the use of complex bridge and vehicle finite element models. In this regard, a case study of a highway composite steel–concrete bridge spanning 40 m was selected in order to demonstrate the usefulness of the presented improved methodology by carrying out a fatigue analysis. The results of this investigation (displacements and stresses) are presented, aiming to verify the factors that directly influence the structural response and, consequently, the service life of steel–concrete composite highway bridges.
Influence of Melt Infiltration Parameters on Structural and Mechanical Properties of Al-4.3wt.%Cu-EP Syntactic Foam
Authors: Niroumand Behzad , Jazini Dorcheh Amir
Published: July 2023

The present research concerns fabrication of Al-4.3wt.%Cu metal syntactic foams using expanded perlite particles (EPPs). A gas pressure infiltration technique was employed to fabricate the aluminium syntactic foams under different infiltration temperatures and pressures. Ambient air pressure and 750 °C were identified as the favoured processing conditions for full infiltration of the melt. The average density and EP volume percentage of the fabricated foams were measured to be about 1.55 g/cm3 and 50.3%, respectively. Melt infiltration is believed to be mainly controlled by the breakage of the aluminium oxide layer on the melt surface and melt viscosity. Preferential infiltration of the melt between the mould wall and the EP particles bed complemented by radial melt infiltration toward the centre of the samples was identified. The effects of EP particles on growth of the nucleated primary α-aluminium phase were discussed. XRD and EDS analyses suggested some chemical reactions at the interface of EPPs with the molten aluminium. T6 heat treatment in the ambient atmosphere improved the average compressive tensile strength, plateau stress, and absorption capacity of the syntactic foams by more than 100%. Uniform deformation and similar densification strains (about 40%) of the as-fabricated and heat-treated syntactic foams during the compression test suggested uniform distribution of EP particles and metallic struts in the aluminium alloy matrix.
Decreased 25-Hydroxy Vitamin D Level Is Associated with All-Cause Mortality in Patients with Type 2 Diabetes at High Cardiovascular Risk
Authors: Stančáková Yaluri Alena , Tkáč Ivan , Tokarčíková Katarína , Kozelová Zuzana , Rašiová Mária , Javorský Martin , Kozárová Miriam
Published: July 2023

Cardiovascular diseases are among the leading causes of morbidity and mortality, particularly in individuals with type 2 diabetes. There is a need for new biomarkers to improve the prediction of cardiovascular events and overall mortality. We investigated the association of selected atherosclerosis related biomarkers, specifically osteoprotegerin (OPG), 25-hydroxy-vitamin D (25(OH)D), C-reactive protein (CRP), lipopolysaccharide-binding protein (LBP), and asymmetric dimethylarginine (ADMA), with the occurrence of any cardiovascular event or all-cause mortality (primary outcome) during a 5.6-year follow-up of 190 patients with type 2 diabetes. Data were analyzed using logistic regression to adjust for baseline cardiovascular status and cardiovascular risk factors. The primary outcome occurred in 89 participants (46.8%) during the study. When analyzed individually, 25(OH)D, CRP, and LBP significantly predicted the primary outcome in multivariable models. However, in a model that included all biomarkers, only a decreased level of 25(OH)D remained a significant predictor of the primary outcome. Moreover, the level of 25(OH)D significantly predicted all-cause mortality: a reduction of 10 ng/mL was associated with a two-fold increase in all-cause mortality. Our study thus demonstrates that vitamin D deficiency was the strongest factor associated with the primary outcome and all-cause mortality after a 5.6-year follow-up in patients with type 2 diabetes at high cardiovascular risk.
Impact of Through-Hole Defects on the Electro-Explosive Properties of Exploding Foil Transducers
Authors: Wang Kexuan , Wang Jiangxu , Li Xinyu , Li Dangjuan , Cheng Junxia , Wang Jia , Wu Shenjiang
Published: July 2023

This study examines the impact of surface defects on the electro-explosive properties of metal explosive foil transducers. Specifically, it focuses on the effects of defects in the bridge foil and their influence on the electrical explosion time and transduction efficiency. To analyze these effects, a current-voltage simulation model is developed to simulate the behavior of a defective bridge foil. The simulation results are validated through experimental current-voltage measurements at both ends of the bridge area. The findings reveal that the presence of through-hole defects on the surface of the bridge foil leads to an advancement in the electrical explosion time and a reduction in the transduction efficiency of the bridge foil. A performance comparison is made between the defective bridge foil and a defect-free copper foil. As observed, a through-hole defect with a radius of 20 μm results in a 1 ns advance in the blast time and a 1.52% decrease in energy conversion efficiency. Similarly, a through-hole defect with a radius of 50 μm causes a 51 ns advancement in the blast time and a 13.96% reduction in the energy conversion efficiency. These findings underscore the detrimental effects of surface defects on the electro-explosive properties, emphasizing the importance of minimizing defects to enhance their performance.
Fiber-to-Chip Three-Dimensional Silicon-on-Insulator Edge Couplers with High Efficiency and Tolerance
Authors: Li Xiaoyu , Yu Shengtao , Gui Chengqun
Published: July 2023

The edge coupler is an indispensable optical device for connecting an external fiber and on-chip waveguide. The coupling efficiency of the edge coupler affects the effective integration of optical circuits. In this study, three-dimensional (3D) edge couplers with high efficiency and tolerance are proposed. The high coupling efficiency of the 3D edge couplers is verified by theoretical calculations. Three couplers are fabricated on a thick-silicon platform via 3D grayscale lithography. At the 1550 nm band, the fiber-to-chip experimental data show that the maximum coupling efficiencies of the three edge couplers are 0.70 dB and 1.34 dB, 0.80 dB and 1.60 dB, and 1.00 dB and 1.14 dB for the TE and TM modes, respectively. At the 1550 nm band, misalignment tolerances measurement data reveal 0.8 dB/0.9 dB tolerance of ±5 μm in the horizontal direction, and 1.7 dB/1.0 dB tolerance of ±2 μm in the vertical direction for TE/TM mode. This study provides a new idea for the design of 3D edge couplers and demonstrates significant superiority in research and industrial applications.
Sanitizing Hatching Eggs with Essential Oils: Avian and Microbiological Safety
Authors: Oliveira Gabriel da Silva , McManus Concepta , de Araújo Maria Viviane , de Sousa Davi Emanuel Ribeiro , de Macêdo Isabel Luana , Castro Marcio Botelho de , Santos Vinícius Machado dos
Published: July 2023

Increased meat and egg production leads to concomitant changes in poultry practices, including the indiscriminate use of formaldehyde to sanitize hatching eggs. Although this sanitizer aids in the increase in poultry production, its toxic potential for man and for avian embryos represents an obstacle to its long-term use. This review assesses whether essential oils fit into the context of hatching egg contamination, reviewing their antimicrobial efficiency, toxicity to poultry embryos and chicks, and their sanitizing effects on poultry production parameters. Studies have indicated that, because they are safer, most of the essential oils studied can be a potential substitute for formaldehyde for minimizing microbial exposure of hatching eggs and embryos. However, complementary studies on the microbiological profile of embryos and chicks hatched from eggs sanitized with essential oils need to be carried out and the economic feasibility of the candidate products should also be considered.
Pyritization and Preservation Model of Chrysophyte Cyst Fossils in Shales during the Triassic Carnian Pluvial Episode, Ordos Basin, China: Evidence from Cyclostratigraphy, Radiometric Dating and Geochemical Analyses
Authors: Cao Jingjing , Gang Wenzhe , Yang Shangru
Published: July 2023

Chrysophyte cyst fossils were widely pyritized and preserved in black shales from the seventh member (Ch7 Mbr) of the Yanchang Formation in the Ordos Basin. The age, pyritization, and preservation model of these fossils have not been studied previously. In this study, the astronomical orbital cycles of the Ch7 Mbr were determined based on the gamma ray series of the Yan56 and Zhen 421 wells. An astronomical time scale (ATS) analysis revealed that the depositional duration of Ch7 Mbr was approximately 5 Ma. According to the 206Pb/238U radiometric dating of zircons using laser ablation inductively coupled plasma mass spectrometry (La-ICP-MS), the tuffs at the bottom of Ch7 Mbr were crystallized at 234 Ma, which served as a geological anchor. The ages of three submembers in Ch7 Mbr were estimated at 234.0–232.4 Ma, 232.4–230.8 Ma, and 230.8–229.1 Ma based on ATS analysis. In addition, chrysophyte cyst fossils were well preserved by pyritization in the Ch7 Mbr black shales. There were six types of microscopic morphologies with different pores, collars, and surface ornamentation under scanning electron microscopy (SEM). The age of the chrysophyte cyst fossils was at least 233.6 Ma in the Triassic Carnian Pluvial Episode (CPE) based on the 405 kyr tuned ATS. Moreover, the paleoredox conditions in Ch7 Mbr were reconstructed, and a preservation model of chrysophyte cyst fossils was established based on geochemical analyses. Fossil pyritization was caused by bacterial sulfate reduction near the water-sediment interface under suboxic to anoxic environmental conditions. Pyritization was initiated on the walls of the chrysophyte cysts by the formation of microcrystalline pyrite. Because of the gradual pyritization of the chrysophyte cyst wall, the organic matter in the interior of the fossil was well preserved.
Lineaments in the Gravity Image of the Border Zone between the Central and Outer Carpathians
Authors: Porzucek Slawomir , Loj Monika , Golonka Jan
Published: July 2023

The research area covers the border zone between the Central and Outer Carpathians. The purpose of this research was the interpretation of this zone based on a gravitational survey. This survey was integrated with the results of surface mapping, a deep seismic survey, and deep drillings. Three major tectonic units are located in this area: the Outer (Flysch) Carpathians, the Pieniny Klippen Belt (PKB), and the Central Carpathians. All three units contain a significant amount of flysch sequences. The lowering of the Bouguer anomaly value from north to south reflects the dip of the crystalline European Plate; in turn, the renewed increase in value correlates very well with the emergence of the crystalline ALCAPA Plate. The range of variability of the Bouguer anomaly value largely masks smaller anomalies in amplitude originating from smaller geological structures. Only three anomalies with significant horizontal extent and greater amplitudes are visible: two are clearly correlated with the Orava-Nowy Targ Basin and the third anomaly is likely connected with the thicker pile of the Outer Carpathian flysch. To separate the boundaries of geological or tectonic structures (lineaments), a horizontal derivative (THDR) and an analytical signal (ASA) were used. Both methods allowed us to confirm existing geological and tectonic boundaries (lineaments) and to identify new ones.
Graphdiyne-Based All-Solid-State Passively Q-Switched Tm:YAP Laser at 2 μm
Authors: Wu Qing , Wang Yanyu , Zhao Gang , Wu Haibin , Hu Yi , Wang Mengke
Published: July 2023

All-solid-state Tm lasers have a wider wavelength range and higher output power compared to other types of lasers. In this work, we demonstrate an all-solid-state, high repetition, Tm:YAP laser Q-switched by a graphdiyne (GDY) saturable absorber. The high-quality optical nonlinear material GDY, synthesized by a cross-coupling method, exhibits a strong nonlinear optical response. The application of GDY as a saturable absorber in the passively Q-switched (PQS) Tm:YAP of an all-solid-state laser has been realized with the shortest pulse duration of ~785 ns and repetition frequency of ~199.6 kHz at a central wavelength of 1985.8 nm. This represents the shortest pulse duration and the highest repetition frequency achieved from GDY in a solid-state Tm laser to date. Our work demonstrates the remarkable nonlinear optical properties of GDY, which holds promising potential in the field of optoelectronics.
Advances in Metal–Organic Frameworks for the Removal of Chemical Warfare Agents: Insights into Hydrolysis and Oxidation Reaction Mechanisms
Authors: Oliver Madeleine C. , Huang Liangliang
Published: July 2023

The destruction of chemical warfare agents (CWAs) is a crucial area of research due to the ongoing evolution of toxic chemicals. Metal–organic frameworks (MOFs), a class of porous crystalline solids, have emerged as promising materials for this purpose. Their remarkable porosity and large surface areas enable superior adsorption, reactivity, and catalytic abilities, making them ideal for capturing and decomposing target species. Moreover, the tunable networks of MOFs allow customization of their chemical functionalities, making them practicable in personal protective equipment and adjustable to dynamic environments. This review paper focuses on experimental and computational studies investigating the removal of CWAs by MOFs, specifically emphasizing the removal of nerve agents (GB, GD, and VX) via hydrolysis and sulfur mustard (HD) via selective photooxidation. Among the different MOFs, zirconium-based MOFs exhibit extraordinary structural stability and reusability, rendering them the most promising materials for the hydrolytic and photooxidative degradation of CWAs. Accordingly, this work primarily concentrates on exploring the intrinsic catalytic reaction mechanisms in Zr-MOFs through first-principles approximations, as well as the design of efficient degradation strategies in the aqueous and solid phases through the establishment of Zr-MOF structure–property relationships. Recent progress in the tuning and functionalization of MOFs is also examined, aiming to enhance practical CWA removal under realistic battlefield conditions. By providing a comprehensive overview of experimental findings and computational insights, this review paper contributes to the advancement of MOF-based strategies for the destruction of CWAs and highlights the potential of these materials to address the challenges associated with chemical warfare.
Activation Energy and Bipolar Switching Properties for the Co-Sputtering of ITOX:SiO2 Thin Films on Resistive Random Access Memory Devices
Authors: Chen Kai-Huang , Cheng Chien-Min , Wang Na-Fu , Kao Ming-Cheng
Published: July 2023

Activation energy, bipolar resistance switching behavior, and the electrical conduction transport properties of ITOX:SiO2 thin film resistive random access memory (RRAM) devices were observed and discussed. The ITOX:SiO2 thin films were prepared using a co-sputtering deposition method on the TiN/Si substrate. For the RRAM device structure fabrication, an Al/ITOX:SiO2/TiN/Si structure was prepared by using aluminum for the top electrode and a TiN material for the bottom electrode. In addition, grain growth, defect reduction, and RRAM device performance of the ITOX:SiO2 thin film for the various oxygen gas flow conditions were observed and described. Based on the I-V curve measurements of the RRAM devices, the turn on-off ratio and the bipolar resistance switching properties of the Al/ITOX:SiO2/TiN/Si RRAM devices in the set and reset states were also obtained. At low operating voltages and high resistance values, the conductance mechanism exhibits hopping conduction mechanisms for set states. Moreover, at high operating voltages, the conductance mechanism behaves as an ohmic conduction current mechanism. Finally, the Al/ITOX:SiO2/TiN/Si RRAM devices demonstrated memory window properties, bipolar resistance switching behavior, and nonvolatile characteristics for next-generation nonvolatile memory applications.
Conservation and Targets of miR-71: A Systematic Review and Meta-Analysis
Authors: Naidoo Devin , Brennan Ryan , de Lencastre Alexandre
Published: July 2023

MicroRNAs (miRNAs) perform a pivotal role in the regulation of gene expression across the animal kingdom. As negative regulators of gene expression, miRNAs have been shown to function in the genetic pathways that control many biological processes and have been implicated in roles in human disease. First identified as an aging-associated gene in C. elegans, miR-71, a miRNA, has a demonstrated capability of regulating processes in numerous different invertebrates, including platyhelminths, mollusks, and insects. In these organisms, miR-71 has been shown to affect a diverse range of pathways, including aging, development, and immune response. However, the exact mechanisms by which miR-71 regulates these pathways are not completely understood. In this paper, we review the identified functions of miR-71 across multiple organisms, including identified gene targets, pathways, and the conditions which affect regulatory action. Additionally, the degree of conservation of miR-71 in the evaluated organisms and the conservation of their predicted binding sites in target 3′ UTRs was measured. These studies may provide an insight on the patterns, interactions, and conditions in which miR-71 is able to exert genotypic and phenotypic influence.
Are Energy and Protein Intakes Lower Than Requirements in Older Adults? An Urgent Issue in Hospitals and Nursing Homes
Authors: Blanquet Marie , Guiguet-Auclair Candy , Berland Pauline , Ducher Guillaume , Sauvage Anaïs , Dadet Sylvain , Guiyedi Vincent , Farigon Nicolas , Bohatier Jérôme , Gerbaud Laurent , Boirie Yves
Published: July 2023

Energy and protein intakes lower than requirements are associated with worsening health outcomes. Here we set out to evaluate gaps between energy and protein intakes and requirements in older adults in hospitals and in nursing homes (NH). A cross-sectional study included 360 inpatients and residents aged 75 years and older in two acute care wards; i.e., a multidisciplinary care unit (MCU) and a geriatric care unit (GCU), a geriatric rehabilitation unit (GRU), and two NH. Intakes were measured for three days. Requirements were based on French National Health Authority recommendations. Energy and protein intakes were under the minimum requirement of 30 kcal/kg/day and 1.2 g/kg/day in 89.5% and 100% of MCU patients, respectively, 75.5% and 64.2% of GCU patients, 92.7% and 90.9% of GRU patients, and 83.8% and 83.8 of NH residents. Intake-to-requirement gaps were not significantly associated with malnutrition, except in the GCU group where non-malnourished patients had higher energy gaps than malnourished patients. Intakes fell dramatically short of requirements in older adults in both hospital and NH settings irrespective of malnutrition status. A new paradigm based on a patient-centered approach should be developed to adapt meals served in hospital and in NH.
Linoleic Acid Induced Changes in SZ95 Sebocytes—Comparison with Palmitic Acid and Arachidonic Acid
Authors: Kovács Dóra , Camera Emanuela , Póliska Szilárd , Cavallo Alessia , Maiellaro Miriam , Dull Katalin , Gruber Florian , Zouboulis Christos C. , Szegedi Andrea , Törőcsik Dániel
Published: July 2023

Linoleic acid (LA) is an essential omega-6 polyunsaturated fatty acid (PUFA) derived from the diet. Sebocytes, whose primary role is to moisturise the skin, process free fatty acids (FFAs) to produce the lipid-rich sebum. Importantly, like other sebum components such as palmitic acid (PA), LA and its derivative arachidonic acid (AA) are known to modulate sebocyte functions. Given the different roles of PA, LA and AA in skin biology, the aim of this study was to assess the specificity of sebocytes for LA and to dissect the different roles of LA and AA in regulating sebocyte functions. Using RNA sequencing, we confirmed that gene expression changes in LA-treated sebocytes were largely distinct from those induced by PA. LA, but not AA, regulated the expression of genes related to cholesterol biosynthesis, androgen and nuclear receptor signalling, keratinisation, lipid homeostasis and differentiation. In contrast, a set of mostly down-regulated genes involved in lipid metabolism and immune functions overlapped in LA- and AA-treated sebocytes. Lipidomic analyses revealed that the changes in the lipid profile of LA-treated sebocytes were more pronounced than those of AA-treated sebocytes, suggesting that LA may serve not only as a precursor of AA but also as a potent regulator of sebaceous lipogenesis, which may not only influence the gene expression profile but also have further specific biological relevance. In conclusion, we have shown that sebocytes are able to respond selectively to different lipid stimuli and that LA-induced effects can be both AA-dependent and independent. Our findings allow for the consideration of LA application in the therapy of sebaceous gland-associated inflammatory skin diseases such as acne, where lipid modulation and selective targeting of AA metabolism are potential treatment options.
Food Sources of Animal Protein in Relation to Overall and Cause-Specific Mortality—Causal Associations or Confounding? An Analysis of the EPIC-Heidelberg Cohort
Authors: Bajracharya Rashmita , Kaaks Rudolf , Katzke Verena
Published: July 2023

While prior prospective iso-caloric substitution studies show a robust association between higher intake of animal protein and risk of mortality, associations observed for mortality risk in relation to major food sources of animal protein have been generally more diverse. We used the EPIC-Heidelberg cohort to examine if confounding, notably, by smoking, adiposity, or alcohol intake, could cause inconsistencies in estimated mortality hazard ratios (HR) related to intake levels of different types of meat and dairy products. Higher intakes of red or processed meats, and lower intakes of milk or cheese, were observed among current heavy smokers, participants with obesity, or heavy alcohol drinkers. Adjusting for age, sex, and total energy intake, risk models showed increased all-cause, cardiovascular, and cancer-related mortality with higher red or processed meat intakes (HR ranging from 1.25 [95% confidence interval = 1.15–1.36] to 1.76 [1.46–2.12] comparing highest to lowest tertiles), but reduced risks for poultry, milk, or cheese (HR ranging from 0.55 [0.43–0.72] to 0.88 [0.81–0.95]). Adjusting further for smoking history, adiposity indices, alcohol consumption, and physical activity levels, the statistical significance of all these observed was erased, except for the association of processed meat intake with cardiovascular mortality (HR = 1.36 [CI = 1.13–1.64]) and cheese intake with cancer mortality (HR = 0.86 [0.76–0.98]), which, however, were substantially attenuated. These findings suggest heavy confounding and provide little support for the hypothesis that animal protein, as a nutrient, is a major determinant of mortality risk.
Changes in Food Consumption and Eating Behaviours of Children and Their Families Living in Italy during the COVID-19 Pandemic: The EPaS-ISS Study
Authors: Nardone Paola , Spinelli Angela , Buoncristiano Marta , Andreozzi Silvia , Bucciarelli Mauro , Giustini Marco , Ciardullo Silvia ,   on behalf of the EPaS-ISS Group
Published: July 2023

The aim of the EPaS-ISS study was to describe the changes in food consumption and eating behaviours of children (mainly aged 8–9 years) and their families between the pre-COVID-19 period (before February/March 2020) and the COVID-19 period (from February/March 2020 to April 2022). A web questionnaire completed by parents was used to collect data. The sociodemographic characteristics of the children and their parents were also explored through the web questionnaire. Seventeen regions out of nineteen and the two autonomous provinces (PA) of Italy participated in the study. The survey was completed for 4863 children (47.9% females). The study showed that only small changes in children’s food consumption happened between the pre-COVID-19 period and the COVID-19 period; in particular, about 25% of parents reported an increase in savoury snacks and sweet food. A decrease in fruit and vegetable (about 8%) and fish (14%) consumption was also found. However, the changes seem to have mainly affected children from most disadvantaged families. The results also indicate positive changes during the COVID-19 pandemic in some families’ eating behaviours, such as eating more home-cooked meals (42%) and family meals (39%), as well as cooking more with children (42%).
Nutritional Strategies for the Prevention and Management of Cow’s Milk Allergy in the Pediatric Age
Authors: Coppola Serena , Carucci Laura , Oglio Franca , Di Sarra Claudia , Ozen Gulsum , Berni Canani Roberto
Published: July 2023

Cow’s milk allergy (CMA) is one of the most common pediatric food allergies. The prevalence and severity of CMA have increased dramatically in the last decades, under the pressure of environmental factors in genetically predisposed individuals. Among the environmental influences, nutritional factors play a crucial role. Diet is the most modifiable factor, representing a potential target for the prevention and treatment of CMA. In this review, we report the most scientific-based nutritional strategies for preventing and managing pediatric CMA. In addition, we propose the most complete supplement of compounds able to prevent nutrient deficiencies in CMA pediatric patients and to positively influence the disease course.
Variation, during Shelf Life, of Functional Properties of Biscuits Enriched with Fibers Extracted from Artichoke (Cynara scolymus L.)
Authors: José Francisco , Collado-Fernández Montserrat , Álvarez-Castellanos Pino
Published: July 2023

To boost revaluation of industrial by-products of artichoke, this research tries to determine the stability throughout storage of phenolic compounds and their antioxidant activity in biscuits enriched with fiber-rich powders extracted from b y-products of artichokes (FRPA). To determine the most stable extraction method, biscuits were formulated with FRPA extracted by two different environmentally friendly extraction solvents: water (W) and a solution of 1% CaCl2∙5H2O (CA) and compared with biscuits made with pea fiber (P) and control biscuits (B) without fiber added. Initially and during storage, the biscuits enriched with FRPA (W, CA) showed a higher content of bioavailable polyphenols and antioxidant activity compared to the control biscuits (B) and the reference fiber (P, pea fiber). In conclusion, FRPA are an excellent source of bioavailable fiber with antioxidant activity, but especially the FRPA extracted with 1% CaCl2∙5H2O (CA), and they could present a good alternative to the use of pea fiber.