bluuebunny/crossref_metadata_2025 huggingface dataset:
Presa El Zapotillo: una discusión de su pertinencia para León, Guanajuato, a una década del conflicto por el agua
Authors: Tagle Zamora Daniel
Published: February 2023

El centro del presente trabajo versa sobre el Acuerdo de Entendimiento para el Aprovechamiento de las Aguas del Río Verde de 2019, el cual asigna 120 millones de metros cúbicos de agua de la presa El Zapotillo para León, Guanajuato. El objetivo de este estudio, basado en la perspectiva de la nueva cultura del agua, es demostrar la inconsistencia institucional guanajuatense, la cual insiste en que dicho volumen de agua es el necesario para su urbe. El fundamento de esta inconsistencia se sustenta con una metodología descriptiva-relacional que analiza la gestión del agua en León (2008-2018), por medio de la cual se determinó que El Zapotillo no resulta imprescindible para dicha ciudad; ello porque la crisis no es física, sino socialmente construida por el organismo operador, problema que requiere atenderse localmente y, en consecuencia, de otra solución.
Stwardnienie rozsiane – diagnostyka i leczenie
Authors: Stępień Adam
Published: February 2023

Wprowadzone niedawno do terapii stwardnienia rozsianego nowe leki mają znacznie większą skuteczność w zmniejszaniu częstości nawrotów i rozwoju niepełnosprawności. Z tego powodu konieczna wydaje się zmiana podejścia terapeutycznego i szybsze wprowadzenie nowych, wysoce skutecznych leków. W pracy zaprezentowano wyniki badań uzasadniające wprowadzanie terapii o wysokiej skuteczności jako leczenia pierwszego wyboru dla pacjentów z aktywną rzutowo-remisyjną postacią stwardnienia rozsianego.
Mianseryna i jej miejsce w praktyce klinicznej
Authors: Gabryelewicz Tomasz
Published: February 2023

Mianseryna jest lekiem o silnym działaniu przeciwdepresyjnym. Złożony mechanizm działania powoduje, że zalicza się go do klasy NaSSA (leki noradrenergiczne i specyficznie serotoninowe). Lek jest skuteczny w leczeniu depresji. W psychogeriatrii chętnie stosuje się go w leczeniu zaburzeń nastroju, zaburzeń snu oraz w stanach niepokoju. Działa również przeciwlękowo. Stosowany jest też jako terapia dodana, potencjalizując leczenie ciężkich depresji. Opisy przypadków dotyczą różnych możliwości stosowania leku w psychogeriatrii.
10 faktów o lewofloksacynie
Authors: Czech Anna Katarzyna , Chłosta Piotr L.
Published: February 2023

Lewofloksacyna to lek bakteriobójczy z grupy fluorochinolonów. Ma szerokie spektrum działania przeciwbakteryjnego obejmujące bakterie Gram(+), Gram(-), wybrane beztlenowce i drobnoustroje atypowe. Lewofloksacynę można stosować w formie dożylnej i doustnej zamiennie. Dawkowanie raz na dobę oraz możliwość przyjmowania niezależnie od posiłków wiążą się z większą wygodą stosowania. Lewofloksacyna osiąga wysokie stężenie w moczu i dobrze przenika do gruczołu krokowego. Znajduje zastosowanie w leczeniu niepowikłanego odmiedniczkowego zapalenia nerek u kobiet, zakażeń dróg moczowych u mężczyzn, powikłanych zakażeń dróg moczowych, zapalenia gruczołu krokowego ostrego i przewlekłego, zapalenia najądrza oraz w leczeniu infekcji dróg oddechowych, skóry i tkanek miękkich.
Zastosowanie etorykoksybu w chorobach układu ruchu – doświadczenia ośrodka warszawskiego
Authors: Rupiński Robert
Published: February 2023

Etorykoksyb – selektywny inhibitor COX-2 (koksyb) – został zarejestrowany w leczeniu choroby zwyrodnieniowej, reumatoidalnego zapalenia stawów, zesztywniającego zapalenia stawów kręgosłupa (spondyloartropatia) oraz dny moczanowej. Silne działanie przeciwbólowe i przeciwzapalne etorykoksybu zostało potwierdzone w randomizowanych badaniach klinicznych obejmujących duże grupy pacjentów. Etorykoksyb w porównaniu z klasycznymi niesteroidowymi lekami przeciwzapalnymi charakteryzuje się blisko 2-krotnie niższym ryzykiem poważnych działań niepożądanych ze strony przewodu pokarmowego. Jednocześnie, podobnie jak w przypadku innych niesteroidowych leków przeciwzapalnych, terapia etorykoksybem jest przeciwwskazana u pacjentów z wysokim ryzykiem sercowo-naczyniowym.
Epidemiology of musculoskeletal injuries in combat sports practitioners
Authors: Sobieraj Tomasz , Kaczmarczyk Katarzyna , Wit Andrzej
Published: February 2023

Study aim: The purpose of this study was to determine the impact of the type of combat sport and the degree of athletic proficiency on the specificity of musculoskeletal injuries suffered by Muay Thai and Mixed Martial Arts practitioners.

Material and methods: The study involved 64 practitioners of two combat sports, MT (age 26.9 ± 8.1, experience 7.4 ± 5.8 years) or MMA (age 26.2 ± 6.4 years, experience 6.6 ± 4.1 years). The research was conducted using a Google Forms survey.

Results: The groups did not differ significantly (p < 0.05) in terms of risk of injury (average 3.1 in MT, 2.6 in MMA). Injuries (mainly fractures 21% and 7% of practitioners) affected the lower limb (44% and 33% practitioners) and were significantly higher in MT, p < 0.05. There were significant (p < 0.05) correlations between training experience and the number of training hours per week compared to the frequency and severity of injuries in both groups.

Conclusion: Injuries to athletes who mainly use striking techniques are more common in the lower limbs and they are more likely to be fractures. Longer training experience, more training hours and a higher level of athletic proficiency significantly increase the risk of injuries and their severity among people practicing both types of combat sports.
Assessment of selected immunological parameters in dairy cows with naturally occurring mycotoxicosis before and after the application of a mycotoxin deactivator
Authors: Brodzki Piotr , Marczuk Jan , Lisiecka Urszula , Krakowski Leszek , Szczubiał Marek , Dąbrowski Roman , Bochniarz Mariola , Kulpa Katarzyna , Brodzki Nikodem , Wolniaczyk Karolina
Published: February 2023

Introduction

Mycotoxins in dairy cows can cause many non-specific symptoms often resulting from immune system overreaction. The study assessed the concentration of selected cytokines and acute phase proteins (APP) in cows with natural mycotoxicosis before and after using a mycotoxin neutraliser. The cytokines were tumour necrosis factor alpha (TNF-α), interleukin 6 (IL-6) and interleukin 10 (IL-10), and the APP were serum amyloid A (SAA) and haptoglobin (Hp).

Material and Methods

The research was carried out on an experimental group (Exp) of 10 herdmate Holstein-Friesian cows with mycotoxicosis. The control group (Con) was 10 healthy cows of the same breed from a different herd. Cows in the Exp group were administered the mycotoxin deactivator Mycofix for three months. Blood was drawn from Exp cows once before administering Mycofix and a second time after three months of its use. Blood was also drawn from Con cows at the same times. Serum levels of TNF-α, IL-6, IL-10, SAA and Hp were assessed using ELISA.

Results

The concentrations of all cytokines and Hp in Exp cows were higher before treatment (P < 0.001) than those in Con cows. After three months of administering Mycofix, the concentrations of TNF-α and IL-6 were significantly lower than their pre-treatment levels (P < 0.001). The concentrations of IL-6, IL-10, and Hp were still significantly higher than those in the Con group (P < 0.001). In cows with mycotoxicosis, simultaneous stimulation of antagonistic processes was noted: a pro-inflammatory process in the upregulation of TNF-α and IL-6, and an anti-inflammatory one in the upregulation of IL-10.

Conclusion

Despite the absorbent’s use and the resolution of clinical symptoms in Exp cows, high levels of IL-10 and Hp and IL-6 were maintained. Assessment of the level of cytokines and APP appears to be a useful and precise tool for the evaluation and application of the appropriate dose of the mycotoxin absorbent or the evaluation of its effectiveness.
Histopatologi Hati Tikus yang Terpapar Logam Berat Timbal
Authors: Karina Elisabeth , Berata I Ketut , Setiasih Ni Luh Eka
Published: February 2023

Timbal merupakan salah satu bahan pencemar udara yang sangat berbahaya.  Toksisitas logam berat Pb dapat menimbulkan dampak yang berat, salah satunya pada organ hati.  Penelitian ini bertujuan untuk mengetahui histopatologi hati pada tikus yang terpapar logam berat timbal  dengan dosis yang berbeda.  Penelitian ini menggunakan tikus putih jantan dengan strain Wistar, umur 2 bulan dan berat badan 250-300 g.  Tikus yang digunakan 20 ekor dibagi atas empat kelompok perlakuan yaitu kontrol (P0), Pb asetat 0,5 ppm (P1), Pb asetat 1,0 ppm (P2), dan Pb asetat 2,0 ppm (P3) selama 30 hari.  Pada hari ke 31 dilakukan nekropsi lalu organ hati diambil dan dimasukkan ke dalam netral buffer formalin 10%.  Setelah organ hati difiksasi, dilakukan pembuatan preparat histopatologi menggunakan pewarnaan Hematoksilin dan Eosin.  Pemeriksaan histopatologi dilakukan meliputi tiga variabel lesi yaitu kongesti, degenerasi melemak, dan nekrosis.  Tingkat keparahan lesi tersebut dibuat skoring yaitu 0, 1, 2 dan 3 masing-masing apabila normal, lesi ringan, sedang dan berat.  Data kemudian dianalisis dengan menggunakan uji non parametik Kruskal-Wallis dan Mann-Whitney.  Hasil penelitian menunjukkan bahwa pemberian logam timbal dengan kandungan 0,5 ppm, 1,0 ppm, dan 2,0 ppm menyebabkan lesi histopatologi hati tikus berupa kongesti dan nekrosis yang signifikan dibandingkan kontrol, kecuali lesi degenerasi melemak.
Isolasi dan Identifikasi Bakteri Shigella spp. Penyebab Diare pada Anjing
Authors: Br Sembiring Voni Cornelia , Suarjana I Gusti Ketut , Pasek Gelgel Ketut Tono
Published: February 2023

Anjing merupakan salah satu hewan kesayangan yang banyak dipelihara oleh masyarakat karena dinilai sebagai hewan yang cerdas dan setia. Salah satu masalah kesehatan utama anjing adalah diare yang disebabkan oleh infeksi bakteri. Shigella spp. merupakan bakteri patogen pada saluran pencernaan anjing. Penelitian ini bertujuan untuk mengisolasi dan mengidentifikasi bakteri Shigella spp. penyebab diare pada anjing. Sampel yang diteliti menggunakan swab rektal pada anjing yang menunjukkan gejala klinis diare dengan jumlah 48 sampel yang berasal dari klinik hewan di kota Denpasar dan sekitarnya. Isolasi Shigella spp. dilakukan pada media Eosin Methylene Blue Agar, Salmonella-Shigella Agar, and Sheep Blood Agar. Koloni yang tumbuh dan terpisah pada media Salmonella-Shigella Agar dilakukan pewarnaan Gram, uji katalase, uji oksidase serta dilanjutkan dengan uji biokimia yaitu uji Triple Sugar Iron Agar, Sulfid Indol Motility, Methyl Red Voges Proskauer, Simmons Citrat Agar, dan uji gula-gula seperti glukosa, laktosa, mannitol, dan arabinosa. Hasil penelitian menunjukkan bahwa dari 48 sampel yang diisolasi dan diidentifikasi, satu sampel menunjukkan hasil positif bakteri Shigella spp. dengan kemungkinan spesies Shigella dysentriae. Disimpulkan bahwa dapat diisolasi dan diidentifikasi sejumlah satu (2,08%) bakteri Shigella spp. dari 48 sampel swab rektal anjing yang menunjukkan gejala klinis diare. Perlu dilakukan penelitian lebih lanjut terhadap tingkat patogenisitas bakteri Shigella spp. dan untuk penelitian selanjutnya perlu dilengkapi dengan uji API 20E untuk menentukan spesies Shigella.
Korelasi Viskositas Mukous Serviks dengan Konsentrasi Estrogen Saat Estrus pada Sapi Aceh
Authors: Thasmi Cut Nila , Listin Cantika Tamara , Husnurrizal Husnurrizal , Sutriana Amalia , Herrialfian Herrialfian , Hafizuddin Hafizuddin , Adam Mulyadi , Dasrul Dasrul , Siregar Tongku Nizwan
Published: February 2023

Viskositas mukus serviks dipengaruhi oleh konsentrasi estrogen. Penelitian ini bertujuan untuk mengetahui hubungan antara viskositas mukus serviks dengan konsentrasi estrogen pada sapi aceh dalam keberhasilan perkawinan. Penelitian ini menggunakan empat ekor sapi aceh betina, umur 3-7 tahun dan memiliki bobot badan 150-250 kg, sudah pernah beranak, dan memiliki dua kali siklus estrus reguler. Seluruh sapi aceh disinkronisasi dengan PGF2a (Dinoprost tromethamine inj., Lutalyse, Zoetis US) dengan metode two shoot secara intra muskular. Koleksi mukus serviks dilakukan secara aspirasi pada hari estrus. Pengukuran viskositas mukus serviks dilakukan dengan melihat nilai spinnbarkeit. Konsentrasi estrogen diukur dengan metode enzyme linked immunosorbant assay (ELISA). Data yang diperoleh pada penelitian ini dianalisis menggunakan uji korelasi pearson. Hasil penelitian menunjukkan bahwa rata-rata viskositas mukus serviks aceh sebesar 11,8±4,6 cm, dan rata-rata konsentrasi estrogen sapi aceh saat estrus sebesar 106,5±15,8 pg/ml. Hubungan antara viskositas mukus serviks dengan konsentrasi estrogen didapatkan hasil 0,983. Kesimpulan dari penelitian ini bahwa semakin tinggi konsentrasi estrogen maka viskositas mukus serviks akan menurun sehingga nilai spinnbarkeit akan meningkat. Perlu dilakukan kajian lebih lanjut terkait karakteristik elektrokimia mukus serviks dan vagina saat estrus meliputi nilai tipologi ferning, electrical resistance vaginal mucus (ERVM), pH, kandungan natrium, magnesium, kalsium dan kation lainnya yang mempengaruhi performa estrus pada sapi aceh.
Revolutionizing Legal Education: Embracing Technology to Equip Students for Success in the Digital Age
Authors: Mochammad Tanzil Multazam
Published: February 2023

The legal profession is changing as law schools embrace technology to prepare students for 21st-century concerns. This conversation covered legal education's technological initiatives, including online training, blended learning, adaptive learning materials, and online mentorship programs. This study aims to provide a detailed review of legal education's technological innovations and their effects on the legal profession. We examined online education, including synchronous and asynchronous distance learning and Massive Open Online Courses (MOOCs), which provide students flexibility and convenience. Blended learning lets law professors use educational videos and other internet resources to make learning more engaging and effective. Technology is revolutionizing legal education and preparing students for the digital age. Law schools may prepare students for a future where technology will be increasingly crucial by adopting new tools and instructional approaches. The study stressed the necessity for forward-thinking legal education and keeping up with legal business technology
RELAÇÃO ENTRE VARIÁVEIS ANTROPOMÉTRICAS E DE APTIDÃO FÍSICA EM CRIANÇAS E ADOLESCENTES ESTRATIFICADOS POR SEXO
Authors: Silveira Igor André Correa , Corrêa Pietra Cazeiro , Da Silva Amanda Franco , Bergmann Gabriel Gustavo , Müller Camila Borges , Pinheiro Eraldo dos Santos
Published: February 2023

A aptidão física (ApF) pode estar associada à saúde, ao desempenho esportivo e refere-se a capacidade de apresentar um determinado desempenho motor quando submetido a situações que envolvam esforços físicos. O objetivo deste estudo foi relacionar as variáveis antropométricas e de aptidão física em crianças e adolescentes da cidade de Pelotas/RS, estratificados por sexo. Foram avaliados 1720 escolares da rede municipal de Pelotas/RS, sendo 896 crianças (idade = 9,91 ± 1,21 anos) e 824 adolescentes (idade = 13,11 ± 1,04 anos), através de uma bateria de avaliações das medidas antropométricas (estatura [EST], massa corporal [MC], envergadura [ENV], índice de massa corporal [IMC]) e de testes físicos (flexibilidade [FLEX], potência de membros superiores [PMS], potência de membros inferiores [PMI], velocidade com troca de direção [VTD], velocidade linear [VL], resistência muscular localizada [RML] e capacidade cardiorrespiratória [CC]). O estudo de caráter de diagnóstico com cunho observacional utilizou o teste de correlação através do r de Pearson e classificou-as como muito fraca (0-0,19), fraca (0,2-0,39), moderada (0,4-0,69), forte (0,7-0,89) e muito forte (0,9-1). Destacou-se que no sexo feminino houve correlação moderada com IMC e PMS, as variáveis antropométricas EST, ENV e MC apresentaram pelo menos uma correlação com as variáveis de ApF, enquanto que estas variáveis demonstraram correlações moderadas entre PMS, VL e VTD. Já no sexo masculino foi observada correlação moderada entre IMC e CC, além de correlações fracas e moderadas entre EST, ENV e MC com pelo menos uma das variáveis de ApF, enquanto as variáveis de ApF demonstraram correlações moderadas entre PMI, VL e VTD. Portanto, ressalta-se a importância do diagnóstico destas variáveis para controle dos fatores de risco à saúde bem como para identificar potenciais relacionados ao desempenho esportivo.
Tentativa de filicídio-suicídio: relato de caso
Authors: Oliveira Micaelle Maria Barros , Alexandre Milena Ferreira de França , Costa Gabrielly Galindo Azevedo , Lima Maria Vitória Silva de , Rodrigues Matheus Duarte , Souza Sofia Oliveira de , Melo Sillas Duarte de , Valença Alexandre Martins , Telles Lisieux Elaine Borba
Published: February 2023

Este trabalho objetiva realizar uma revisão sobre o tema de filicídio e descrever o caso de uma genitora que tentou exterminar sua prole e planejava cometer suicídio logo em seguida. É discutida a classificação do evento, os fatores de risco e precipitantes, o papel dos transtornos mentais e as possibilidades de investigação e prevenção de filicídio.
Agua y gas en todos los pisos: condiciones de la producción visual en el espacio de los flujos
Authors:   Universidad de La Laguna (España), Arozena Teresa
Published: February 2023

«Water and Gas for All Apartments. Visual Production Conditions in A Space of Flow». In the context of the information society new production and distribution mechanisms of artistic experience are described, analysing the current process of redefining and rearticulating the public and private space that is taking place under the combined effect of the concept of information technology and the social processes and forms within online society. Current problems concerning knowledge flow, apparently circumscribed to the legal and financial world, are presented as a key element to understanding new visual production mechanisms, understood as the sphere in which new identities are constructed.
Evaluation of CO2enhanced oil recovery and CO2storage potential in oil reservoirs of petroliferous sedimentary basin, China
Authors: Wang Peng-Tao , Wu Xi , Ge Gangke , Wang Xiaoyan , Xu Mao , Wang Feiyin , Zhang Yang , Wang Haifeng , Zheng Yan
Published: February 2023

Carbon Capture, Utilization, and Storage (CCUS) technology has emerged as the bottom-line technology for achieving carbon neutrality goals in China. The development of Carbon Dioxide Enhanced Oil Recovery (CO2-EOR) not only increases revenue for high-investment CCUS projects but also enables permanent CO2storage in the oil reservoir. However, the basin is used as the research object to evaluate the CO2storage potential of the oil reservoir. The evaluation results are inaccurate and unable to support the implementation of later CCUS projects. Here, more accurate oil reservoir data is employed as the evaluation object. It is the first time at the national level to screen oil reservoirs to distinguish between CO2miscible and immiscible, and evaluate the potential of CO2-EOR and CO2storage in the reservoir. The research results show a total of 2570 suitable oil reservoirs in 4386 candidate oil reservoirs nationwide. About 1.26 billion tons of additional crude oil can be produced by CO2-EOR technology. This includes approximately 580 million tons of additional oil from CO2miscible flooding and 680 million tons from CO2immiscible flooding. The study further refines the CO2geological utilization data and provides a theoretical basis for CCUS project site selection in China.
Identification of palliative care requirement in hospital inpatients in internal medicine services in a peruvian reference hospital
Authors: Velasquez-Manrique Annie , Benavides-Luyo Claudia , Chaupi-Rojas Susan , Andahua-Inuma Sandra , Andrade-Acuña Manuel , Sánchez-Ruiz Rubén , Soto Alonso
Published: February 2023

Introduction: Hospitals of greater complexity tend to care for patients with advanced chronic diseases, which is why it is important to recognize the need for palliative care. Objective: To identify the proportion of patients who require palliative care in the medicine department of a Peruvian referral hospital. Methodology: Observational, analytical, cross-sectional study. All hospitalized patients were studied in the Department of Internal Medicine of the Peruvian hospital during the period April-May 2018. To determine the need for palliative care, the NECPAL CCOMS-ICO © instrument was used. The quantitative variables are presented as median and interquartile range (IQR); and numerical variables, such as frequencies and percentages. For the comparison of numerical variables, the Mann Whitney test was used and the chi-square test for categorical variables. Results: They were evaluated in 281, where 102 (37.9%) required palliative care. The median age in patients requiring palliative care was 69.5 (IQR: 58-81) years. The median hospital stay in patients with and without the need for palliative care was 7 days (IQR: 4-11) and 9 days (IQR: 5-19) respectively, the mortality in patients with and without the need for palliative care was 37.25% and 4.19% respectively. Conclusions: There is a high frequency of need for palliative care in patients hospitalized in internal medicine wards, the requirement for palliative care was associated with higher mortality and hospital stay, which evidences the need for comprehensive and personalized care based on medical services specialized.
Loss of interest for training in paediatric surgery in India
Authors: MAHALIK SANTOSH KUMAR , PATI AKASH BIHARI , DAS KANISHKA
Published: February 2023

Background

Despite the sizeable Indian paediatric population, few students have opted for postdoctoral (Magister Chirurgiae [MCh]/Diplomate of the National Board of Examinations [DNB]) courses in the past decade. We analyse the apparent loss of interest for training in paediatric surgery in India and suggest remedies.

Methods

We did a combination of an online questionnaire-based survey and several interviews among students, teachers and practitioners of paediatric surgery. The results were collated and analysed.

Results

Information from 238 questionnaires, 35 interviews and 75 feedbacks were distilled. About 83% of respondents agreed to a definite loss of interest among students in paediatric surgery, largely because of poor exposure during undergraduate/postgraduate courses and absence of a department in medical colleges. The blanket increase in seats has led to vacancies. The low saleability of paediatric surgery is linked to high personnel and infrastructure investment, modest remunerative potential and poor insurance cover for patients. Besides increasing public awareness, strategic governmental patronage in postdoctoral training (e.g. establishing a department in medical colleges, moderating the number of seats, encouraging performing training centres and rationalizing the bond after the training course) and facilitation of patient care (e.g. insurance cover for congenital conditions and paediatric surgeon in neonatal care units in district hospitals) is suggested.

Conclusions

The loss of interest in paediatric surgery among medical trainees is real and urgently requires a multipronged strategy by the medical fraternity, professional organizations and regulatory bodies across government and non-governmental sectors to facilitate a revival and cater to the sick surgical child in the future.
Challenges and opportunities in providing palliative care services to children with a life-limiting illness: A systematic review
Authors: AGRAWAL UMA SHANKER , SARIN JYOTI , BAKHSHI SAMEER , GARG RAKESH
Published: February 2023

Background

Palliative care for children is an innovative approach that helps improve the quality of life of children suffering from life-limiting illnesses, and their family members. The WHO recognized palliative care as a part of universal health coverage. However, there is inadequate availability and inequitable distribution of palliative care services for children in most parts of the world. We reviewed the existing literature to assess (i) the challenges in providing palliative care services for children suffering from life-limiting illnesses and (ii) the strategies or opportunities to overcome these challenges.

Methods

We conducted systematic searches in the PubMed and Scopus databases to find articles published in the past 10 years (January 2011 to December 2020). The population, concept and context (PCC) framework was used to devise a search strategy in an electronic database.

Results

A total of 1562 articles were found by searching the database and other sources. Title and abstracts of articles were screened, and 206 articles were selected for full-text review. After scrutiny 28 articles met the inclusion criteria. Barriers to and opportunities in the provision of palliative care services for children were identified at policy, organizational, healthcare provider, and patient/family levels.

Conclusion

We found that the majority of barriers to provision of palliative care services for children with life-limiting illnesses can be addressed by adopting research-driven strategies. Adequate and equitable distribution of palliative care services is required for improving children and their family members’ quality of life.
Transient Bell’s palsy following Covid-19 vaccination
Authors: JAGADEESAN SUBRAMANI , KHAN URVASHI , JAIN AJAY
Published: February 2023

Bell’s palsy is described as an acute, unilateral mononeuropathy of the facial nerve resulting in partial or complete paralysis of the face with no identifiable cause. Although facial palsy is often idiopathic, its development soon after the BB-152 Covid vaccine is exceedingly rare. We report a patient with transient acute-onset unilateral infranuclear facial palsy following vaccination, after an exhaustive work-up for other common causes was negative. With no detectable aetiology the likelihood of an association of the Covid-19 vaccine and Bell’s palsy remains.
Başınçlı Pişirmenin Kaldirik Bitkisinin Antioksidan Kapasitesi ve Toplam Fenolik Madde Miktarı Üzerine Etkisi
Authors: Demirel Özbek Yağmur , Türker Perim , Saral Özlem
Published: February 2023

Sebzeler antioksidan bakımından oldukça zengin bir besin kaynaklarıdır. Pişirme yöntemleri sebzelerin antioksidan kapasitesinde değişikliğe neden olmaktadır. Bu çalışmanın amacı, farklı sürelerde basınçlı pişirme uygulanan kaldirik bitkisinin toplam fenolik madde miktarı ve antioksidan kapasitesine etkisini incelemektir. Çalışmada toplam fenolik madde miktarı, demir (III) iyonu indirgeme kapasitesi, bakır (II) iyonu indirgeme kapasitesi ve DPPH• (2,2-difenil-1-pikrilhidrazil) radikal süpürme kapasitesi ölçümü yapılmıştır. Çalışma sonucunda basınçlı pişirme işlemi uygulanan kaldirik bitkisinin çiğ halinin toplam fenolik madde miktarı ve antioksidan kapasitesi bakımından 3 dk ve 10 dk pişirilmesi sonucunda arttığı belirlenmiştir. 5 dk basınçlı pişirme ile çiğ kaldirik bitkisinin toplam fenolik madde miktarı ve antioksidan kapasitesi bakımından yaklaşık olarak benzer olduğu sonucuna varılmıştır. Antioksidan kapasite ve toplam fenolik madde miktarı birbirine benzer iken (p>0.05), 5 dk pişirilen kaldiriğin antioksidan kapasitesi ve toplam fenolik madde miktarı 3 dk ve 10 dk pişirilen kaldirik bitkisine göre de düşük olduğu saptanmıştır (p<0.05). Bu çalışmanın sonucunda antioksidan kapasite ve fenolik miktar için basınçlı pişirme yöntemi süresinin önemli olduğunu ortaya konmuştur.
Initial Activities Encouraging Students’ Autonomous Learning: Faculty Teacher Training and Education Program
Authors: Khulaifiyah Khulaifiyah , Widiati Utami , Anugerahwati Mirjam , Suryati Nunung
Published: February 2023

Initial activities become important as the stepstone to raise students’ autonomous level. The study aims to explore lecturers’ initial activities to encourage students’ autonomous learning. Autonomous learning is a process to be apprehensive of taking control of literacy. This study used a case study and a content analysis in the qualitative exploration. The English teacher educators at the English language education department, the faculty of teacher training and education in Pekanbaru became the research samples. A qualitative approach is chosen as exploration design with the help of Nvivo 12 Apps since interviews come as the main instrument. Some interview points questioned how lecturers help learners comprehend the material, determine their particular pretensions, chancing out supporting coffers. The study reveals that the lecturer's exertion as the initial activities were giving the material explanation, giving information about the course figure, giving assignments, giving what students need, giving provocation or motivation, sharing experiences, making personal approach, exercising, being a Model, making agreement letter, warning, having a concession, having references of material, participating gests, checking students’ appreciation by reviewing, giving question and test. Yet, giving assignments collectively or in collaboration, systems or incidental test becomes a proposed exertion in the initial process to enhance learners’ autonomous.
BIOTESTING THE SAFETY OF MICROBIAL BIOLOGICAL PRODUCTS USED AS ANTAGONISTS OF ASPERGILLUS FLAVUS AND FUSARIUM SPOROTRICHIOIDES
Authors: Хабирова С.Р. , Шуралев Э.А.
Published: February 2023

В работе представлены результаты биотестирования перспективных антагонистов Aspergillus flavus и Fusarium sporotrichioides. Оценка фитотоксичности изучаемых бактерий позволила отнести две из пяти исследуемых бактерий к микроорганизмам, проявляющим негативный эффект в отношении растений, так как РБ12 простимулировало рост семян лишь в 30% при разведении 1:10, и 40% при разведении 1:100. При применении бактерий РБ20 семена проросли в 85% случаев при разведении 1:10, 90% при разведении 1:100. Были отобраны три изолята для дальнейшего исследования (РБ10, РБ15, РБ16), не проявивших фитотоксического действия. При проведении биотестирования на мышах и крысах было выявлено, что изучаемые бактерии не вызвали острой реакции у лабораторных животных. В опытах хронической токсичности установлено, что негативного влияния на прирост массы животных и на гематологические показатели ежедневное введение бактериальной суспензии на протяжении 60 сут не оказало, что свидетельствует об отсутствии токсичности данных бактерий. Используя методику MALDY-TOF данные бактерии отнесены к фенотипически различающимся штаммам Bacillus subtilis.

The ecotoxicological evaluation of the most promising antagonists of Aspergillus flavus and Fusarium sporotrichioides was carried out in the work. Determination of the phytotoxicity of the studied bacteria made it possible to classify two of the five studied bacteria as microorganisms that have a negative effect on plants, since RB12 stimulated seed growth only in 30% at a dilution of 1:10, and 40% at a dilution of 1:100. When using the bacterium RB 20, the seeds germinated in 85% of cases at a dilution of 1:10, 90% at a dilution of 1:100. Thus, three bacteria were selected that did not show a phytotoxic effect for further study (RB10, RB15, RB16). When conducting biotesting on mice and rats, it was found that the studied bacteria did not cause an acute reaction in laboratory animals. In chronic toxicity experiments, it was noted that the daily administration of the bacterial suspension for 60 days did not have a negative effect on the weight gain of animals and on hematological parameters, which indicates the non-toxicity of these bacteria. Using the MALDY-TOF method, these bacteria were classified as phenotypically different strains of Bacillus subtilis.
THE ROLE OF MEADOWS IN NATURAL FODDER SOURCES IN THE NORTH-EASTERN PART OF THE SMALL CAUCASUS
Authors: Тагиева З.И.
Published: February 2023

Одним из важнейших участков природных кормовых источников в Азербайджане являются естественные сенокосы. Общая площадь естественных лугов в нашей республике составляет около 150 тыс. га. Большинство из них расположены в горной и предгорной зонах территории Азербайджана, в лесах, вокруг лесных троп, по берегам рек. В ряде зон луга формируются на остепненных склонах, среди кустарников на полупустынных равнинах, иногда в стоячей воде. Естественные кормовые угодья составляют 3396,4 тыс. га, что составляет 39,3% территории республики. Из них 113,4 тыс. га составляют луга, 1460 тыс. га – зимние пастбища, 589,5 тыс. га – летние пастбища, 1233,4 тыс. га – луга вокруг села. В Гянджа-Газахском районе 30,6 тыс. га сенокосы площадей.

One of the most important areas of natural fodder sources in Azerbaijan is natural hayfields. The total area of natural meadows in our republic is about 150 thousand hectares. Most of them are located in the mountainous and foothill zones of the territory of Azerbaijan, in forests, around of forest lanes, on river banks. In a number of zones, meadows are formed on steppe slopes, among bushes in semi-desert plains, and sometimes in standing water. Natural fodder areas are 3396.4 thousand hectares, which is 39.3% of the territory of the republic. Of these, 113.4 thousand hectares are meadows, 1460 thousand hectares are winter pastures, 589.5 hectares are summer pastures, and 1233.4 thousand hectares are meadows around the village. There are 30.6 thousand hectares of mowing area in Ganja-Gazakh region.
ENVIRONMENTAL ASPECT OF THE DEVELOPMENT OF THE TOURISM INDUSTRY IN THE COASTAL TERRITORIES OF THE PACIFIC RUSSIA
Authors: Степанько Н.Г.
Published: February 2023

Целью исследования является оценка эколого-экономической ситуации на прибрежных территориях Тихоокеанской России для выявления территорий, благоприятных для развития туризма. Наиболее привлекательны и востребованы прибрежные территории Тихоокеанской России: Чукотского АО, Камчатского и Приморского краев, Сахалинской области. Эти регионы неравнозначны по природно-климатическим условиям, социально-экономическому развитию, демографической ситуации, развитию туристской инфраструктуры. Но все они уникальны по своим природным условиям и ресурсам и являются основой развития туристского вида деятельности в рассматриваемых регионах. В работе использован системный подход, методы картографирования, сравнительного анализа, а также метод определения координаты (показателя) в n-мерном Евклидовом пространстве. Данный метод позволяет получить интегральный показатель (координату) из n-ого количества показателей, измеряемых в разных единицах и в дальнейшем отслеживать изменения изучаемого объекта в целом, а также его отдельных составляющих, таким образом отследив какой именно параметр повлиял на изменение состояния объекта. На основе полученных результатов проведено зонирование выбранной территории, которое позволяет определить наиболее экологически комфортные территории для создания или дальнейшего развития туристического вида хозяйственной деятельности. Полученные результаты могут быть использованы в отраслевых структурах управленческих аппаратов, комитетов по туризму. Территории для создания или дальнейшего развития туристического вида хозяйственной деятельности.

The purpose of the study is to assess the ecological and economic situation in the coastal areas of Pacific Russia in order to identify areas favorable for the development of tourism. The most attractive and in demand are the coastal territories of Pacific Russia: Chukotka Autonomous Okrug, Kamchatka and Primorsky Territories, and the Sakhalin Region. These regions are unequal in terms of natural and climatic conditions, socio-economic development, demographic situation, development of tourism infrastructure. But all of them are unique in their natural conditions and resources and are the basis for the development of tourism activities in the regions under consideration. The work uses a systematic approach, methods of mapping, comparative analysis, as well as a method for determining the coordinate (indicator) in the n-dimensional Euclidean space. This method allows you to get an integral indicator (coordinate) from the n-th number of indicators measured in different units and further track changes in the object under study as a whole, as well as its individual components, thus tracking which parameter influenced the change in the state of the object. Based on the results obtained, the zoning of the selected territory was carried out, which makes it possible to determine the most environmentally friendly territories for the creation or further development of a tourist type of economic activity.
GEOECOLOGICAL ASPECTS AT THE FACILITIES OF THE OIL AND GAS COMPLEX
Authors: Казанкова Э.Р. , Корнилова Н.В.
Published: February 2023

Рассматривается новый подход к изучению взаимозависимости природных и техногенных геодинамических процессов в нефтегазовой промышленности. Рассмотрены факторы, возникающие и сопровождающие геодинамические явления при разработке месторождений углеводородов, их транспортировке и хранении.

A new approach to the study of the interdependence of natural and man-made geodynamic processes in the oil and gas industry is considered. The factors arising and accompanying geodynamic phenomena during the development of hydrocarbon deposits, their transportation and storage are considered.
NOISE REDUCTION OF MEASURING EQUIPMENT IN PAIRED AMPLIFIERS: THE PROBLEM OF UNBALANCED NOISE
Authors: Абатуров М.А.
Published: February 2023

Был рассмотрен способ снижения напряжения внутренних шумов в схеме с параллельным соединением двух усилителей. Показано, что предельное снижение в √2 раза возможно только при полном равенстве уровней шумов составляющих усилителей. При превышении шумов одного из усилителей более чем в √3 раза эффект полностью пропадает. Сделан вывод о необходимости тщательного подбора спаренных усилителей с разбалансом по шумам не более чем в 1.25 раза для достижения эффекта снижения шумов не хуже, чем 0.80. Результаты работы будут полезны при создании прецизионной аппаратуры.

A method for reducing the voltage of internal interference in a circuit with parallel connection of two amplifiers is considered. It is shown that the maximum reduction by √2 times is possible only if the noise levels of the amplifier components are completely equal. If the noise of one of the amplifiers is exceeded by more than √3 times, the effect disappears completely. It is concluded that it is necessary to carefully select paired amplifiers with a noise imbalance of no more than 1.25 times in order to achieve a noise reduction effect no worse than 0.80. The results of the work will be useful when creating high-precision equipment.
SELECTION OF MATERIALS AND TECHNOLOGIES FOR PIPELINES TRANSPORTING CORROSIVE ENVIRONMENT, USING NEURAL NETWORKS
Authors: Зорин Е.Е. , Деркач Д.В. , Кравчени М.С.
Published: February 2023

В статье рассмотрены подходы и алгоритмы использующие нейронные сети при выборе материального исполнения и технологии сварки для повышения длительной работоспособности технологических трубопроводов газоконденсатных месторождений Крайнего Севера, транспортирующих коррозионноактивные углеводороды высоких параметров.
RESTORATION AND IMPROVEMENT OF STRUCTURAL STRENGTH OF AIRCRAFT STRUCTURAL ELEMENTS BY TREATMENT WITH PULSATING SUBSONIC GAS FLOWS
Authors: Иванов Д.А.
Published: February 2023

В данной статье рассматривается вопрос применения разработанных автором бездеформационных технологий восстановления и повышения как механических, так и эксплуатационных свойств металлических конструкционных материалов на основе воздействия импульсами давления дозвукового потока газа (газоимпульсной обработки) в ходе технического обслуживания и восстановительного ремонта элементов конструкции воздушного транспорта. Результаты представленных в статье исследований позволяют рекомендовать использование газоимпульсной обработки при решении задач восстановления и сохранения летной годности воздушных судов.

This article discusses the issue of the application of non-deformational technologies developed by the author to restore and improve both mechanical and operational properties of metal structural materials based on the impact of subsonic gas flow pressure pulses (gas pulse treatment) during maintenance and repair of structural elements of air transport. The results of the research presented in the article allow us to recommend the use of gas pulse processing in solving the problems of restoring and maintaining the airworthiness of aircraft.
Flow-Mediated Dilation Can be used as an Indicator for Assessing Severity and Deaths by Covid-19 at the Initial Hours of Hospitalization
Authors:   Cardiopulmonary Physiotherapy Laboratory, Physiotherapy Department, Federal University of Sao Carlos, Brazil, MR Oliveira , CL Goulart ,   Cardiopulmonary Physiotherapy Laboratory, Physiotherapy Department, Federal University of Sao Carlos, Brazil, GD Back ,   Cardiopulmonary Physiotherapy Laboratory, Physiotherapy Department, Federal University of Sao Carlos, Brazil, AB Silva ,   Cardiopulmonary Physiotherapy Laboratory, Physiotherapy Department, Federal University of Sao Carlos, Brazil
Published: February 2023

Assessment of Flow-Mediated Dilation (FMD) in patients hospitalized for COVID-19 will assist with regard to early identification of markers at the onset of SARS-CoV-2 infection. Therefore, the early evaluation of simple markers, obtained at the bedside before the most serious manifestations are already installed, can help health professionals to act preventively to save lives, direct care in the initial stage of infection, helping in the prognosis and diagnosis. Given the importance and relevance of this technique in this population at this time and the need to better understand the pathophysiology of COVID-19 as well as its damage to the endothelium, we performed an evaluation of FMD in different severity of COVID-19 in recently hospitalized patients. A total of 100 patients were enrolled in the study and were divided into two groups according to the severity of COVID- 19. The results provide new evidence that patients with COVID-19 classified as severe/critical have greater endothelial dysfunction and that FMD may be a simple marker, helping in the prognosis and diagnosis and, consequently, in the prevention of thrombotic events.
Comment on "A single level tunneling model for molecular junctions: evaluating the simulation methods'" by Opodi et al
Authors: Baldea Ioan
Published: February 2023

The present Comment demonstrates important flaws of the paper Phys. Chem. Chem. Phys. 2022, 24, 11958 by Opodi et al. Their crown result ("applicability map'') aims at indicating parameter ranges wherein two approximate methods (called method 2 and 3) apply. My calculations reveal that the applicability map is a factual error. Deviations of I2 from the exact current I1</> do not exceed 3% for model parameters where Opodi et al claimed that method 2 is inapplicable. As for method 3, the parameter range of the applicability map is beyond its scope, as stated in papers cited by Opodi et al themselves.
Predicting Magnetic Coupling and Spin-Polarization Energy in Triangulene Analogues
Authors: Yu Hongde , Sun Jianwei , Heine Thomas
Published: February 2023

Triangulene and its analogue metal-free magnetic systems have garnered increasing attention since their discovery. Predicting the magnetic couplings and spin polarization energy is beyond the predictive power of todays density-functional theory (DFT) due to their intrinsic multi-reference character. Herein, we create a benchmark dataset of 25 magnetic systems with non-local spin densities, including the triangulene monomer, dimer, and their analogues. We calculate the magnetic coupling (J) and spin-polarization energy (Espin) of these systems using complete active space self-consistent field (CASSCF) and coupled cluster methods as high-quality reference values. This reference data is then used to benchmark 22 DFT functionals commonly used in material science. Our results show that, while some functionals consistently correctly predict the qualitative character of the ground state, achieving quantitative accuracy with small relative errors is currently not feasible. PBE0, M06-2X, and MN15 are predicting the correct electronic ground state for all systems investigated here, and also have the lowest mean absolute error for predicting both Espin (0.34 eV, 0.32 eV and 0.31 eV) and J (13.36 meV, 13.39 meV and 11.76 meV). They may therefore also serve as starting points for higher-level methods such as the GW or the random phase approximation. As other functionals fail for the prediction of the ground state, they cannot be recommended for metal-free magnetic systems.
Analytic First-Order Derivatives of CASPT2 with IPEA shift
Authors: Nishimoto Yoshio
Published: February 2023

Complete active space second-order perturbation theory (CASPT2) is useful for accurately predicting properties of complex electronic structures, but it is well known that it systematically underestimates excitation energies. The underestimation can be corrected using the ionization potential--electron affinity (IPEA) shift. In this study, analytic first-order derivatives of CASPT2 with IPEA shift are developed. CASPT2-IPEA is not invariant with respect to rotations among active molecular orbitals, and two additional constraint conditions are necessary in the CASPT2 Lagrangian to formulate analytic derivatives. The method developed here is applied to methylpyrimidine derivatives and cytosine, and minimum energy structures and conical intersections are located. By comparing energies relative to the closed-shell ground state, we find that the agreement with experiments and high-level calculations is indeed improved by inclusion of the IPEA shift. The agreement of geometrical parameters with high-level calculations may also be improved in some cases.
End-to-End Differentiable Force Field Generator with Crystal Structure Differentiation and Matching
Authors: Nakano Hiroshi , Hattori Shinnosuke , Kobayashi Hajime , Araki Takumi , Ukita Masakazu , Nishi Toshio , Kudo Yoshihiro
Published: February 2023

Differentiable programming has accelerated the development of force-field (FF) parameterization techniques. Specifically, automatic differentiation (AD) facilitates energy and force matching by differentiating them with respect to the FF parameters; hereinafter, referred to as force differentiation and matching (FDM). Conversely, crystal structure matching with AD has persisted as a challenge because the converged structures optimized by the iterative algorithm cannot be differentiated with respect to the FF parameters. Therefore, in this paper, we propose a structure differentiation and matching (SDM) method, wherein the converged structures are directly differentiated using the parameters with implicit function differentiation and matched with the experimental crystal structures. Subsequently, with a case study, we compared the reproducibility of the crystal structures, internal atomic coordinates, and lattice energies on eight exemplary molecules with the differentiable Ewald method for long-range interactions. The results indicated that SDM outperformed FDM on all three criteria. The FFs generated by SDM reproduced the lattice constants with a mean error of 0.56 %, the internal atomic coordinates with an error of 0.16 Angstrom, and the lattice energies with an error of 0.14 kcal/mol. The corresponding accuracies obtained with FDM were 1.2 %, 0.22 Angstrom, and 2.40 kcal/mol, respectively. Furthermore, we performed molecular dynamic simulations on a supercell, containing more than 3000 atoms, to confirm if the crystal structures were preserved under temperature fluctuations at 300 K.Overall, this method is not limited to Amber-type FFs and can be easily applied to the other types of FFs. Thus, we believe that SDM will emerge as one of the new standards for parameterizing FFs with crystal structures.