bluuebunny/crossref_metadata_2025 huggingface dataset:
THE VERTICAL LAND USE ZONING FOR UNDERGROUND SPACE DEVELOPMENT IN MALAYSIA
Authors: Zaini Farah , Suratman Robiah , Che Kassim Asmma’
Published: December 2021

There is a demand for the development of underground space beneath alienated land by a third party other than the surface landowner. Arguments frequently arise because the surface landowner asserts that his rights extend to ownership extension, while the other party wishes to develop the underground space without interfering with the rights of others. Due to Malaysia's absent of land use zoning for underground space, the rights to develop underground space are ambiguous. Using a qualitative approach, this study will examine the role of land use zoning in assisting the development of underground spaces. Thematic analyses revealed three interconnected elements: underground land use zoning, standardisation of land category depths, and a buffer zone for surface and underground space ownership. Additionally, a comparative study was conducted between Malaysia, Hong Kong, China, Japan, and Finland in order to determine the optimal strategy for zoning underground space land uses. At the conclusion of this paper, verticalland use zoning was also proposed.
THE RELATIONSHIP OF LAND USE CHANGES AND LAND SURFACE TEMPERATURE FOR URBAN AREA IN KUCHING, SARAWAK
Authors: Ali Abdullah Sufi , Zaini Farah , Jamian Mohd Azizul Hafiz
Published: December 2021

Land surface temperature (LST) is used as an indicator for land temperature.Previous research demonstrates a strong correlation between urban growth andland surface temperature. The rising of land temperature will lead to urban heatisland if there are no preventative precautions done. Due to the area's rapidurbanisation, this study will focus on Kuching City. Matang Jaya, Tabuan Jaya,Satok, and Batu Kawa were chosen as case studies. These areas are rapidlydeveloping, with new townships and population growth. The Landsat 7 data setwas used as secondary data in this study. Spatial and thermal analysis wereperformed on the output using ERDAS software and ArcGIS. The analysesderived land use changes between 2005 and 2017, temperature statistics for landuse types, and LST retrieval for case studies. The result indicates that the landsurface temperature increased with the case studies' physical development.
AN IMPROVEMENT OF INTEGRATED GEOGRAPHICAL INFORMATION SYSTEM IN MANAGING SEWERAGE TREATMENT PLANT
Authors: Idris Muhamad Zuraini , Suratman Robiah , Shamsuddin Salfarina
Published: December 2021

In Malaysia, the Geographical Information System (GIS) is widely used by various organizations in both government and private sectors because of its various capabilities. The rapid development process in the large city in Peninsular Malaysia and new area has caused an increasing number of the sewerage treatment plant (STP) maintained by Indah Water Konsortium Sdn Bhd (IWK) every year. Nowadays, with the big services areas and limited staffs the IWK had faced many issues related to the sewerage such as a public complaint on blockage, overflow and others. Thus, based on the powerful function of this GIS, the IWK also has used the GIS application known as Integrated Geographical Information System (IGIS) in their daily routine works. However, due to the weaknesses of this existing system, it cannot be optimally utilized in managing and maintaining the sewerage system more efficient. The main objective of this research focuses on analyzing user requirements to improve IGIS based on the current issues faced by them. The method used in this study is qualitative method using a face-to-face interview with IGIS users in getting any feedback from them on the existing data with an examining what is the main attribute data required. Then a content analysis was used to analyze it by updating all the data required and removing unnecessary data from the IGIS. As a result, the newly updated attribute data into IGIS will help the users to conduct proper planning in controlling the increasing number of STP every year and to manage the sewerage system more efficiently.
КЛІНІЧНІ ВАРІАНТИ ПЕРВИННОГО ГІПЕРПАРАТИРЕОЗУ В ПАЦІЄНТІВ, ОБСТЕЖЕНИХ В ЕНДОКРИНОЛОГІЧНІЙ КЛІНІЦІ
Authors: Дубовик Віктор , Гончарова Ольга , Дубівська Світлана
Published: December 2021

Мета дослідження. Встановити структуру клінічних варіантів первинного гіперпаратиреозу (ПГПТ) у пацієнтів, обстежених в умовах ендокринологічної клініки. Матеріали та методи. Обстежено 36 хворих з ПГПТ, пролікованих в хірургічному відділенні клініки ДУ «ІПЕП» за період 2018-2020 р.р. Проаналізовано скарги, стан кісткової, серцево-судинної, травної систем і нирок. Досліджено рівні паратгормону (ПТГ) в сироватці крові, загального і іонізованого кальцію крові, фосфору крові, рівня кальційурії та фосфорурії. Проведено УЗД органів шиї. Результати. Серед обстеженої групи переважали жінки. У всіх хворих при УЗД виявлено аденоми паращитоподібних залоз. При цьому у 70% мала місце м'яка форма захворювання. У 30% обстежених хворих встановлена органна патологія, в т.ч. з боку нирок (22,2%), серцево-судинної системи (19,4%), травного тракту (13,8%), кісткової системи (13,8%). У більшості хворих встановлено значне підвищення загального та іонізованого кальцію крові, яке завжди супроводжувалося підвищенням рівня ПТГ. В постопераційному періоді на першу добу достовірно знизилися рівні ПТГ (˂0,05), а на 3-4 добу відбулося зниження рівня валентного та іонізованого Са (˂0,05). Висновки. З метою оптимізації роботи з виявлення хворих з ПГПТ рекомендувати сімейним лікарям направляти до ендокринолога пацієнтів зі скаргами на загальну слабкість, втрату апетиту, міалгії, болі в кістках. Особливу увагу необхідно приділяти особам з патологічними переломами, рецидивуючою сечокам'яною хворобою, кістами верхньої щелепи. Виявлення підвищеного кальцію в крові, навіть незначного, дозволить зв'язати ці скарги з наявністю гіперпаратиреозу. Доцільно використовувати на амбулаторному прийомі опитувальники, які дозволяють швидко і ретельно досліджувати патологічний стан пацієнтів. На сьогодні хірургічне лікування є найбільш ефективним методом лікування первинного гіперпаратиреозу. Воно повинно проводитися навіть при асимптомних формах захворювання, що дозволяє попередити розвиток важких, невиліковних ускладнень.
РІВНІ МОНОЦИТАРНОГО ХЕМОАТРАКТАНТНОГО ПРОТЕЇНУ-1 У ХВОРИХ НА ЦУКРОВИЙ ДІАБЕТ 2 ТИПУ У ПОЄДНАННІ З ІШЕМІЧНОЮ ХВОРОБОЮ СЕРЦЯ
Authors: Серік Сергій , Мавричева Наталія , Ченчик Тетяна
Published: December 2021

Актуальність. Механізми атеросклеротичних серцево-судинних захворювань при цукровому діабеті (ЦД) остаточно не визначені. Моноцитарний хемоатрактантний протеїн-1 (МХП-1) є прозапальним хемокіном, який відіграє ключову роль у патофізіології як атеросклерозу, так і діабету.
Мета дослідження: вивчити рівні МХП-1 у хворих на ІХС з ЦД 2 типу у залежності від перенесеного в минулому інфаркту міокарда та перкутанного коронарного втручання (ПКВ).
Матеріали і методи. У 31 хворого на стабільну ІХС з ЦД 2 типу, 26 пацієнтів з ІХС без ЦД, 15 осіб контрольної групи визначали сироваткові рівні МХП-1 імуноферментним методом.
Результати. Рівні МХП-1 у хворих на ІХС з ЦД 2 типу були вище, ніж в осіб контрольної групи (p=0,0007) та у пацієнтів з ІХС без ЦД (р=0,039). У хворих на ІХС без ЦД рівні МХП-1 збільшувались незначуще. Кореляцій рівню МХП-1 з глюкометаболічними та ліпідними показниками в жодній групі не виявлено. У хворих і з ЦД 2 типу, і без ЦД не встановлено істотних відмінностей у рівнях МХП-1 між пацієнтами з і без інфаркту міокарда. У хворих на ІХС з ЦД 2 типу, які мали в анамнезі ПКВ давністю більшою за 1 рік, рівень МХП‑1 був достовірно вище, ніж у пацієнтів без ПКВ (p=0,038). У хворих на ІХС без ЦД 2 типу з проведеним в минулому ПКВ рівень МХП‑1 виявився значуще меншим відносно пацієнтів без ПКВ (p=0,030).
Висновки. У хворих на ІХС з ЦД 2 типу рівень МХП-1 збільшувався у порівнянні з контролем та пацієнтами з ІХС без ЦД. Хворі на ІХС з ЦД 2 типу з ПКВ в анамнезі мали найвищий рівень МХП-1.
НЕЙРОГУМОРАЛЬНІ ПРОФІЛІ ТА ІНСУЛІНОРЕЗИСТЕНТНІСТЬ У ХВОРИХ НА АРТЕРІАЛЬНУ ГІПЕРТЕНЗІЮ
Authors: Шевчук Сергій , Корчинський Володимир
Published: December 2021

Мета дослідження: вивчення показників вуглеводного обміну, активності ренін-ангіотензин-альдостеронової системи (РААС), глюкокортикоїдної функції наднирників, кальцій-регулюючих і тиреоїдних гормонів і їх можливих взаємозв’язків у хворих на артеріальну гіпертензію (АГ) з інсулінорезистентністю (ІР) в залежності від стану вегетативного тонусу.
Проведено комплексне дослідження гормонального профілю радіоімунним методом і вегетативного тонусу у 68 хворих на АГ II стадії, 1-2 ступеня, чоловічої статі (середній вік – 53,7 ± 3,4 роки), з індексом маси тіла до 30 кг/м² і верифікованою ІР, з яких у 37 хворих переважав симпатичний тонус (І група), у 31 хворого – парасимпатичний тонус (ІІ група). Інсулінорезистентність верифікували за величиною індексу Царо (глюкоза, ммоль/л / інсулін, мкОд/мл), що не перевищувала 0,33. Для оцінки стану вегетативної нервової системи проводили варіаційну пульсометрію.
В ході дослідження встановлено, що у хворих на АГ з ІР при симпатикотонії підвищений вміст катаболічних гормонів: тиреотропного гормону, тироксину, трийодтироніну, кортизолу, кальцитоніну, альдостерону, при парасимпатикотонії – анаболічних гормонів: інсуліну, паратгормону, прогестерону. Існує тісний взаємозв’язок між тиреоїдними і кальцій-регулюючими гормонами, інсуліном в регуляції вуглеводного обміну і формуванні ІР, посередниками якого є система аденілатциклази, вміст внутрішньоклітинного Ca²⁺ і Mg²⁺. Вплив кальцій-регулюючих гормонів на розвиток ІР у хворих на АГ залежить від вегетативного тонусу. Механізми взаємодії інсуліну і РААС при АГ з ІР залежать від концентрації гормонів, глюкокортикоїдної функції наднирників, активності вегетативної нервової системи.
Висновки: нейрогуморальний профіль і міжгормональні взаємодії при АГ впливають на механізми формування ІР залежно від вегетативного тонусу: при перевазі парасимпатичного тонусу, ймовірно, переважають рецепторні і пострецепторні механізми ІР, при АГ з симпатикотонією – на рівні клітин-мішеней інсулінчутливих тканин.
EVIDENCE OF APOPTOSIS IN PARVOCELLULAR NUCLEI OF HYPOTHALAMUS IN DIABETES MELLITUS
Authors: Zhurakivska Oksana , Zherdova Nadiia , Oliinyk Roman , Pobigun Nadiia , Kostitska Iryna , Zhurakivskyi Viktor , Miskiv Vasyl , Tkachuk Yurii , Antymys Olga , Sahan Nazar , Kniazevych-Chorna Tetiana
Published: December 2021

Diabetes mellitus (DM) causes great socio-economic damage, which is determined by medical expenses and expenditure on social security to patients due to invalidity and loss of labour capacity. Researchers are studying the role of hypothalamic neuropeptides and their involvement in the regulation of pancreatic islet function. In view of the above, the aim of our study was to establish the features of morphofunctional changes in the arcuate nucleus (AN) and ventromedial nucleus (VN) of the hypothalamus in streptozotocin-induced diabetes mellitus (SIDM).

Histological, immunohistochemical, electron-microscopic, biochemical and statistical research methods were used.

Polymorphic changes were noted in AN and VN at early stages of development of SIDM (on the 14th day). In AN, the area of neurons and their nuclei became larger, the numerical density of dark functionally more active neurons increased, and dinuclear light neuroendocrine cells (NC) appeared. In light and dark NCs of AN, there was a significant increase in the bulk density of neurosecretory granules – by 2-4 times compared with the control, in VN – by 1.2-2 times.

Such morphofunctional changes in parvocellular nuclei of the hypothalamus and the increase in the bulk density of neurosecretory granules in their NCs indicate boosted synthesis of neurohormones which directly affect the adenohypophysis and improving functional activity of NCs in AN and VN.

On the 70th day of SIDM in AN and VN of the hypothalamus, there was a decrease in the numerical density of neurons due to light NC and increase in the numerical density of vacuolated, dark pycnomorphic and apoptotic neurons. The apoptotic index in the studied nuclei of the hypothalamus increased by 2-4 times compared with the control. The area of the profile field of NC increased and the area of nuclei decreased, which led to the reduced nuclear-cytoplasmic index and indicated a decrease in their functional activity and was confirmed by a decrease in the bulk density of neurosecretory granules in NC by 1.9-2.1 times in AN and by 2.7-4.7 times in VN. At the ultrastructural level, pronounced destructive processes such as vacuolar dystrophy, development of satelliteosis and neuronophagia were observed in light NCs.

Thus, prolonged hyperglycemia in SIDM in parvocellular nuclei of the hypothalamus causes neuronal death to a lesser extent due to apoptosis, and to a greater extentdue due to hydropic dystrophy and colliquative necrosis, especially in the long term of the experiment (on the 70th day), and leads to the development of diabetic neuroendocrinopathy.
ДОСВІД ТА ПЕРСПЕКТИВИ ЗАСТОСУВАННЯ КАРБОКСІТЕРАПІЇ ПРИ ЦУКРОВОМУ ДІАБЕТІ
Authors: Дроговоз Світлана , Бєлік Галина , Калько Катерина , Шевченко Станіслав , Деримедвідь Людмила , Кіреєв Ігор , Штробля Анжела
Published: December 2021

Цукровий діабет (ЦД) є глобальною актуальною соціальною проблемою XXI століття.
Метою даного огляду літератури: є аналіз фізіологічних властивостей та фармакотерапевтичних можливостей карбоксітерапії, а також досвіду застосування даного методу для лікування ЦД.
Матеріали і методи дослідження. Наукові публікації в зарубіжних та вітчизняних журналах переважно за останні 5 років, інтернет ресурси по карбоксітерапії як методу лікування ЦД.
Результати досліджувати і їх обговорення. В результаті аналізу літератури були зіставленні механізми реалізації фармакологічних ефектів карбоксітерапії з окремими ланками патогенезу ЦД. Проаналізовані механізми і ефекти карбоксітерапії як ефективного альтернативного методу лікування ЦД та його ускладнень. Представлені дані свідчать про раціональність застосування карбоксітерапії як альтернативного методу лікування ЦД та його ускладнень.
Висновки. З огляду на сучасні можливості фармакотерапії ЦД та більш ніж п’ятдесятирічний досвід застосування карбоксітерапії в практичній медицині дозволяє рекомендувати цей інноваційний метод як альтернативну off-label терапію ЦД.
Ключові слова: цукровий діабет, лікування, карбоксітерапія.
 
 
EXPERIENCE AND PROSPECTS OF CARBOXYTHERAPY IN DIABETES MELLITUS
Drogovoz S. M.1, Belik G. V.1, Kalko К. О.1,
Bondariev Ye. V.1, Derymedvid L. V.1, Orlenko І. V.1, Shtroblya А. L.2
National University of Pharmacy, Kharkiv, Ukraine
Uzhgorod National University, Uzhgorod, Ukraine
 
Diabetes mellitus (DM) is a global topical social problem of the XXI century.
The aim of this literature review is to analyze the physiological properties and pharmacotherapeutic possibilities of carboxytherapy, as well as the experience of this method for the treatment of diabetes.
Materials and methods. Scientific publications in foreign and domestic journals mainly for the last 5 years, online resources on carboxytherapy as a method of DM treating.
Results and discussions. As a result of the literature analysis, the mechanisms of implementation of the pharmacological effects with separate links of the pathogenesis of diabetes were compared. The mechanisms and effects of carboxytherapy as an effective alternative method for treating diabetes mellitus and its complications have been analyzed. The presented data indicate the rational use of carboxytherapy as an alternative method for treating diabetes and its complications.
Conclusions. Given the current possibilities of pharmacotherapy of diabetes and more than fifty years of experience in the use of carboxytherapy in practical medicine allows us to recommend this innovative method as an alternative to off-label therapy of diabetes.
Key words: diabetes mellitus, treatment, carboxytherapy.
MENOPAUSE AS A FACTOR OF ORAL HEALTH
Authors: Mazur Iryna , Tatarchuk Tetiana , Kosey N. V. , Zanko О. V. , Efimenko Olga
Published: December 2021

General increase of longevity in Ukraine and around the world along with the increasing number of women over 50 necessitates implementation of comprehensive scientifically based programs aimed to improve health and quality of life of this part of population.

The aim of this review of international and Ukrainian studies was to investigate in depth hormone associated mechanisms of pathologic conditions formation in peri- and postmenopausal women.

Materials and methods. Studies on association of climacteric symptoms and symptoms of dental pathology were analyzed.

Results. Our literature review showed worse condition of dental health in menopausal women. The pres­ence of estrogen receptors in oral mucosa and salivary glands increases the risk of dental pathology when ovarian function diminishes. Gradual decrease of ovarian steroids in female body causes changes in oral microbiota and changes microbial landscape of periodontal pockets and effects local immunity. This causes increase of oral mucosa pathology such as glossodynia or burning mouth syndrome, lichen planus and angular cheilitis. It also causes the increase of periodontal diseases rate.

Conclusions. Cross-disciplinary interaction of dentists and gynecologists-endocrinologists will provide possibilities to discover more common causes and pathogenic mechanisms of periodontal diseases and oral mucosa in menopausal women. This will provide possibilities for the development of comprehensive approach to diagnosis, treatment and prophylaxis.
Análisis de redes sociales: Una herramienta para la extensión agropecuaria
Authors: Martínez Medrano Juan Carlos , Contreras Valencia Katia Vanesa , Molano Bernal Lilia Constanza
Published: December 2021

En la actualidad casi todo el mundo ha oído hablar de instagram, tik-tok, facebook, tweter, etc.; estas plataformas se basan en el concepto de «redes sociales» y lo usan con diferentes propósitos. En esta cartilla usamos ese concepto para mostrar de forma práctica, cómo se pueden analizar las relaciones entre productores en el contexto de la extensión agropecuaria. Entender la forma en que se relacionan los diferentes productores en una región resulta ser una información valiosa para diseñar una estrategia basada en una eficiente gestión del conocimiento. Saber que los productores, a partir de sus relaciones, han constituido redes centralizadas o distribuidas puede determinar seguir caminos muy diferentes para difundir un conocimiento en esa comunidad. Invitamos a los extensionistas a probar estas herramientas y averiguar cómo se generan las redes de productores y cómo se puede ir mejorando la comunicación y la creación de conocimiento al intervenirlas.
Звернення головного редактора проф. І.П. Мазур
Authors: Mazur I.P.
Published: December 2021

No abstract
До питання класифікації та пов’язаної з нею термінології хвороб пародонта: історіографічний аналіз
Authors: Mazur I.P. , Mazur P.V.
Published: December 2021

У статті наведено історіографічний аналіз літературних джерел і медико-технологічних документів щодо термінології та класифікації хвороб пародонта, що використовували в Україні протягом останніх 120 років. Актуальність обговорення стоматологічною спільнотою питання щодо термінології та класифікації хвороб пародонта зумовлена необхідністю запровадження клінічних настанов та уніфікованих протоколів надання стоматологічної допомоги на основі доказової медицини й запровадження нової класифікації та введення відповідних термінів.
Melihat Peran Perantara dalam Kasus Penyebaran Video Non-Konsensual dengan Kerangka Contextual Integrity
Authors: Saraswati Idha
Published: December 2021

Jumlah kasus kekerasan berbasis gender online atau KBGO selama masa pandemi dilaporkan meningkat. Penambahan jumlah pengguna internet serta kian masifnya tranformasi digital selama masa pandemi dipandang berkontribusi dalam peningkatan kasus KBGO tersebut. Kekerasan berbasis gender yang selama ini sudah marak terjadi di ranah offline menemukan ruang baru di dunia online sehingga kian mengancam keamanan, kesehatan dan keselamatan perempuan. Dalam kasus KBGO, dua pihak yang paling banyak dibicarakan adalah pelaku dan korban. Namun, pembicaraan tersebut melupakan pihak lain yang juga berpengaruh penting dalam terjadinya kekerasan, yakni platform digital yang menjadi wadah maupun memfasilitasi peristiwa kekerasan. Platform digital seperti media sosial tercatat menjadi salah satu medium terjadinya KBGO. Tulisan ini memaparkan peran platform digital sebagai perantara dalam kasus kekerasan, khususnya KBGO, dengan menerapkan kerangka contextual integrity yang diajukan Nissenbaum (2010) pada kasus penyebaran video intim non-konsensual yang menimpa GA dan GL. Tulisan ini menunjukkan bahwa melalui sistem dan kebijakan layanannya, pihak perantara turut berperan dalam mendorong terjadinya  KBGO.

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The number of online gender based violence (OGBV) cases in Indonesia are reportedly increasing during the pandemic. The increasing number of internet users and the massive digital transformation during the pandemic has contributed to the escalation in OGBV cases. Gender-based violence has found a new space in the online world, thus threatening women’s security, health, and safety. In the OGBV case, the two parties that has been discussed the most were the perpetrators and the victims. However, the discussion forgot about the other party that also had an important influence, namely the digital platform. Digital platfarm like social media has become the medium for OGBV.This paper describes the role of the digital platform as an intermediary party for communication exchange in the cases of online violence, especially OGBV, by applying the contextual integrity framework proposed by Nissenbaum (2010) in the dissemination of non-consensual intimate videos of GA and GL cases. This paper shows that through its system and policies, digital platforms play significant role in facilitating OGBV.
Analisis Wacana Kritis Komentar Seksual dalam Media Sosial Twitter Laki-Laki Berekspresi Gender Feminin
Authors: Ayuningrum Nara Garini
Published: December 2021

Pandemi COVID-19 memaksa masyarakat untuk mengisolasi diri mereka masing-masing demi mencegah penyebaran virus. Hal ini meningkatkan aktivitas daring para individu demi memenuhi segala kebutuhan dan kewajiban. Tidak hanya aplikasi berbasis jasa yang mengalami peningkatan aktivitas pengguna, tetapi juga aplikasi media sosial, salah satunya adalah Twitter. Dengan berbagai fitur yang ditawarkan, Twitter tidak hanya mempermudah individu untuk berkomunikasi dengan orang-orang yang dikenalnya, tetapi juga membuka peluang untuk berinteraksi dengan pengguna lain tanpa adanya batasan. Twitter memungkinkan penggunanya untuk mengunggah swafoto dan membiarkan pengguna lain untuk mengomentari swafoto/unggahan tersebut. Dalam penelitian ini, penulis akan menganalisis komentar-komentar bernada seksual yang ada pada swafoto akun @dododid_ selama periode tahun 2020. Dengan menggunakan metode analisis wacana kritis Norman Fairclough, peneliti menemukan 3 wacana besar terkait swafoto laki-laki berekspresi gender feminin, yaitu wacana cantik = perempuan, wacana objektifikasi dan stigma dan stereotipe. Melalui penelitian ini penulis juga menemukan bahwa kekerasan  gender berbasis online bisa dialami oleh siapa saja dalam bentuk yang bermacam-macam.

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The COVID-19 forces people to isolate themselves to prevent the spread of the virus. COVID-19 increases the online activities of individuals to meet all their needs and obligations. Not only service-based applications that increased user activity, but also social media applications, which is Twitter. With the various features that Twitter offers, it not only makes it easier for individuals to communicate with people they know, but also opens up opportunities to interact with other users without any restrictions. Twitter allows its users to upload selfies and allows other users to comment on those selfies/uploads. In this research, authors analyzed sexually comments on @dododid_ selfies during the 2020 period. Using Norman Fairclough's critical discourse analysis method, authors found 3 major discourses related to selfies of men with feminine gender expression, that are beautiful discourse = women, objectification discourse and stigma and stereotypes. Through this study the author also found that online-based gender violence can be experienced by anyone in various forms.
Berebut Kuasa Tubuh: Norma Agama dan Kuasa Tubuh dalam Kekerasan Gender Berbasis Online
Authors: Imawan Rafif Pamenang
Published: December 2021

Kajian ini akan mengeksplorasi kekerasan berbasis gender dengan mengeksplorasi pengaturan data pribadi dan solusi dominasi patriarki dalam masalah media online. Dengan menggunakan tinjauan pustaka sistematis, tujuan dari penelitian ini adalah memberikan peta kompleksitas dalam masalah pemanfaatan media sosial online. Harapan dari penelitian ini adalah dapat memberikan informasi kepada pembaca tentang masalah hakikat kekerasan berbasis gender online dengan memberikan peta permasalahan sosial di Indonesia. Selain itu, secara akademis, tulisan ini akan mengeksplorasi teori postmodernisme tentang gender, ruang media sosial dan online serta masalah pola pikir struktural terkait kekerasan berbasis gender. Dalam ranah yang lebih praktis, tulisan ini akan memberikan landasan dasar bagi para pemangku kepentingan untuk merumuskan kebijakan terkait kekerasan berbasis gender secara online.

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The COVID-19 forces people to isolate themselves to prevent the spread of the virus. COVID-19 increases the online activities of individuals to meet all their needs and obligations. Not only service-based applications that increased user activity, but also social media applications, which is Twitter. With the various features that Twitter offers, it not only makes it easier for individuals to communicate with people they know, but also opens up opportunities to interact with other users without any restrictions. Twitter allows its users to upload selfies and allows other users to comment on those selfies/uploads. In this research, authors analyzed sexually comments on @dododid_ selfies during the 2020 period. Using Norman Fairclough's critical discourse analysis method, authors found 3 major discourses related to selfies of men with feminine gender expression, that are beautiful discourse = women, objectification discourse and stigma and stereotypes. Through this study the author also found that online-based gender violence can be experienced by anyone in various forms.
ANTIHYPERLIPIDEMIC EFFECT OF THE ETHANOL EXTRACT FRACTION FROM MULBERRY (MORUS AUSTRALIS POIR.) LEAVES ON RATS INDUCED HIGH FAT-DIET (HFD) AND PROPYLTHIOURACIL (PTU)
Authors: TENDA PRISKA ERNESTINA , TOYO ELEONORA MARYETA , RAMADANI ARBA PRAMUNDITA
Published: December 2021

Objectives: To evaluate the effect of extract and its fraction (n-hexane, ethyl acetate, and water) of the mulberry leaf (Morus australis Poir.) in reducing triglyceride and total cholesterol levels on HFD and PTU induced rats.

Methods: In this study, mulberry leaves were collected from East Nusa Tenggara-Indonesia, extracted using maceration method, and fractionated with various solvents. The thin layer chromatography with silica gel 60 F254 was utilized to identify the active compound on both extract and fraction. Furthermore, using a quasi-experimental with control group design, this study employed 40 healthy male Wistar rats and divided into 8 groups, namely: normal and negative control, positive controls (simvastatin and gemfibrozil), ethanolic extract, and fractions (n-hexane, ethyl acetate, and water). All groups were fed with a high cholesterol diet and 0.01% PTU, except for the normal group. During the study, the blood was drawn at day 0, 28, 35, and 42. The triglyceride level was observed using Glycerophosphate-Oxidase Phenol Aminoantipyrine (GPO-PAP) method, while the total cholesterol was measured by Cholesterol Oxidase Phenol Aminoantipyrine (CHOD-PAP).

Results: On the 42nd day, ethyl fraction of mulberry leaf (Morus australis Poir.) showed the most significant result of reducing the level of triglyceride and total cholesterol compared to the high-fat diet and PTU induced rat on day 0: triglyceride of 104.89±2.70 mg/dl vs 64.76±1.97 mg/dl and total cholesterol of 96.70±2.45 vs 88.02±1.38 mg/dl. Ethyl acetate fraction was similar to simvastatin in lowering the level of total cholesterol. TLC identification also showed that mulberry leaf contains flavonoids and polyphenols that act as anti-hyperlipidemic.

Conclusion: Ethyl acetate fraction of mulberry leaf (Morus australis Poir.) showed best activity on lowering both triglyceride and total cholesterol.
THE MOLECULAR INTERACTION AND ADMET PREDICTION OF MODIFIED JPH203 AS A POTENTIAL RADIOPHARMACEUTICAL KIT FOR MOLECULAR IMAGING OF CANCER: AN IN SILICO RESEARCH
Authors: HOLIK HOLIS ABDUL , IBRAHIM FAISAL MAULANA , WIANATALIE ELISHA , ACHMAD ARIFUDIN , FARIED AHMAD , KARTAMIHARDJA ACHMAD HUSSEIN SUNDAWA
Published: December 2021

Objective: In this study, various types of pharmacokinetic modifying linkers and chelators are combined with JPH203 to obtain the best-docked molecule for prospective radiopharmaceutical kits.

Methods: AutoDock 4.2.6 and AutoDockTools 1.5.6 programs was used to do the molecular docking simulation and ADMET prediction was done using VNN-ADMET to predict the pharmacokinetics and toxicity of the ligand.

Results: The result of this study showed that JPH203-linker K-NOTA has the best affinity with a docking score of about-10.7 kcal/mol and shows hydrogen interaction with Tyr259, which acts as key residue of the active site.

Conclusion: Based on the results, JPH203-linker K-NOTA has good potential as a radiopharmaceutical kit of cancer.
DEVELOPMENT OF PAPER-BASED ANALYTICAL DEVICE FOR DETECTING DIAZEPAM IN URINE
Authors: PRATIWI RIMADANI , AMALIA NISA , HASANAH ALIYA NUR
Published: December 2021

Objective: The aim of this study was to develop Paper-based Analytical Devices (PADs) with colorimetric method as a presumptive test for detecting diazepam in urine

Methods: Colorimetric method was used as a principle of this study. PADs were fabricated with wax-printing methods. Chosen colorimetric reagent was tested for selectivity with hydromorphone and codeine; and sensitivity by measuring the absorbance with UV-Vis spectrophotometer. PADs were tested for its sensitivity and stability. The intensity of color developed on PADs are measured with ImageJ. The ability of PADs to detect diazepam in urine was simulated with testing spiked urine sample to the PADs

Results: Zimmermann gave the most obvious prominent color change from colorless to purple-red color out of the four reagents. PAD is selective to diazepam when tested with hydromorphone and codeine. PAD is sensitive with a cut-off concentration at 100 ppm. PAD can detect diazepam in urine with the highest recovery percent at 92.8%±4,6

Conclusion: It can be concluded that PAD is quite selective and sensitive to detect diazepam in urine and can be done easily and fast for onsite analysis
IN SILICO STUDIES OF (S)-2-AMINO-4-(3,5-DICHLOROPHENYL) BUTANOIC ACID AGAINST LAT1 AS A RADIOTHERANOSTIC AGENT OF CANCER
Authors: HOLIK HOLIS ABDUL , IBRAHIM FAISAL MAULANA , FATAH ABIB LATIFU , ACHMAD ARIFUDIN , KARTAMIHARDJA ACHMAD HUSSEIN SUNDAWA
Published: December 2021

Objective: This study aims to obtain a good activity of radiotheranostic kit for cancer which is built by combining (S)-2-amino-4-(3,5-dichlorophenyl) butanoic acid (ADPB) with various bifunctional chelators.

Methods: This study was conducted through in silico method that consists of molecular docking simulation using AutoDock 4 as well as ADMET prediction using vNN-ADMET and Pre-ADMET. Six bifunctional chelators (i.e. CTPA, DOTA, H2CB-TE2A, H2CB-DO2A, NOTA, and TETA) were conjugated with ADPB as a carrier molecule and further analyzed through molecular docking and ADMET prediction.

Results: The results showed that the ADPB-NOTA has the best affinity with the Gibbs free energy (ΔG) of-7.68 kcal/mol with an inhibition constant of 2.36 µM and its ability to bind with the gating residue of LAT1 (ASN258) through hydrogen interactions. Besides that, the ADPB-NOTA compound has a good ADME profile and is predicted to be safe for human use.

Conclusion: This study showed that ADPB-NOTA is the most prospective candidate to be used as a radiotheranostic agent.
Face Mask Detection Using Machine Learning
Authors: Saxena Kavita
Published: December 2021

Abstract: COVID-19 epidemic has affected our daily life disturbing the world trade and transport. Wearing a face mask has become a new necessity for safety. In the near future, many institutions will ask the customers to wear masks to avail of their services. Therefore, face mask detection has become a necessity to help society. This paper presents a simplified approach to achieve this purpose using some packages like TensorFlow, Keras, OpenCV and Scikit-Learn. This method detects the face from the image in frame and then identifies if it has worn a mask or not. As in a surveillance task, it can also detect a face along with a mask in movement through image processing. The method attains accuracy up to 93% and 91.2% respectively on two datasets. We explore optimized values of parameters using the Sequential CNN (Convolutional Neural Network) model to detect the presence of masks correctly. Keywords: Face Mask Detection, Convolutional Neural Network, TensorFlow, Keras, Image Processing
A Review on Image Denoising Techniques
Authors: Tempe Smita Vasant
Published: December 2021

Abstract: The goal of this study is to find a "genuine" two-dimensional transform that can capture the fundamental geometrical structure that is important in visual information. The discontinuous character of the data is the most difficult aspect of analysing geometry in photographs. Unlike previous approaches, such as curvelets, which generate a transform in the continuous domain and then discretize for sampled data, we begin with a discrete-domain construction and then investigate its convergence to a continuous-domain expansion. We use nonseparable filter banks to create a discrete-domain multiresolution and multidirection expansion, similar to how wavelets are produced from filter banks. As a result of this construction, a flexible multiresolution, local, and directed picture expansion employing contour segments is obtained, and it is therefore useful.
Scanning Hybrid Transaction Algorithm for Secure Financial Transactions
Authors: Joshi Divyansh
Published: December 2021

Abstract: Identity theft is a frightening and often very serious concern to everyone. A novel risk-mitigation algorithm, the Hybrid Transaction Algorithm, is given in an effort to provide individuals with peace of mind (HTA). With the random codes, the proposed HTA aims to implement two-factor authentication. This kind of user authentication has been generally recognized, and many businesses have begun to employ it as a security feature. This may be used to identify people and provide a secure method of buying products online. The suggested method involves using mobile devices to log into card accounts using an application in order to examine the randomly generated code. This is then entered when required on an online retailer's website in order to verify the person making the transaction. This reduces the chance of an unauthorized user using someone else's details to make fraudulent transactions. Identity thieves cannot use stolen card information to make transactions unless they have a valid code. This, in turn, protects both the customer and the credit card companies, who may be financially affected. We give one case study to demonstrate the security of our methodology in order to better understand how it may safeguard someone from having a stolen credit card used. Keywords: Two-Factor Authentication; Hybrid Transaction Algorithm (HTA); AES Encryption; SHA–256.
Carbon Capture and Sequestration: An Overview
Authors: Srivastava Kartika
Published: December 2021

Abstract: Carbon dioxide capture and sequestration (CCS) is the capture and storage of carbon dioxide (CO2) that is emitted to the atmosphere as a result of combustion process. Presently majority of efforts focus on the removal of carbon dioxide directly from industrial plants and thereby storing it in geological reservoirs. The principle is to achieve a carbon neutral budget if not carbon negative, and thereby mitigate global climate change. Currently, fossil fuels are the predominant source of the global energy generation and the trend will continue for the rest of the century. Fossil fuels supply over 63% of all primary energy; the rest is contributed by nuclear, hydro-electricity and renewable energy. Although research and investments are being targeted to increase the percentage of renewable energy and foster conservation and efficiency improvements of fossil-fuel usage, development of CCS technology is the most important tool likely to play a pivotal role in addressing this crisis. [1] Keywords: Carbon Capture and Storage, Carbon dioxide, fossil fuels, Greenhouse gases
Competencias digitales: cómo se definen, entienden y miden
Authors: Dodel Matías , Brandino Leticia
Published: December 2021

En el presente Working Paper presenta un estado del arte acerca de la definición, clasificación y operacionalización sobre las competencias digitales, así como un muy inicial análisis de su vínculo con otras competencias y con modelos de desigualdades socio digitales. Se presenta un desarrollo de las características básicas de las competencias digitales, así como de diferentes nombres y tipologías que se utilizan en cinco marcos conceptuales surgidos tanto desde ámbitos académicos como de hacedores de políticas públicas y la cooperación internacional: Media Information Literacy de la UNESCO, el marco de "Educación para la ciudadanía digital" (DCE) de la Unión Europea, el marco de competencias digitales para los ciudadanos (DigComp) de la Unión Europea, el marco de la Alfabetización computacional y de la Información (CIL) del Estudio Internacional de Alfabetización Informática y de la Información (ICILS) y el marco de competencias digitales de Van Dijk, luego ampliado por Van Deursen, Helsper y Eynon. Luego, el Working Paper gira hacia la pregunta sobre los avances y desafíos para la medición de las competencias digitales. Se discuten tres grandes enfoques para medir las habilidades digitales: i) soluciones tipo proxy, ii) observación directa o evaluación en entornos tipo laboratorio, y iii) una diversidad de estrategias de autoevaluación o autorreporte generalmente adaptados para encuestas a gran escala. Se plantean sus fortalezas y limitaciones para la medición del fenómeno. Finalmente, en base a lo discutido y a lo realizado por el grupo de investigación se plantean líneas de trabajo a futuro.
Understanding the relationship between sharing personal anecdotes, warmth, curiosity, risk perception and mitigation in communicating the threat of climate change
Authors: Maktoufi Reyhaneh
Published: December 2021

While most Americans believes in climate change, to elicit action, communicators should use strategies to convey risks. One strategy is to cognitively engage individuals by eliciting curiosity. Previous studies have shown that individuals with higher science curiosity are more likely to perceive the risk of climate change. This study uses scientists’ act of sharing personal anecdotes to elicit curiosity and examines the effect of scientist’s traits on risk perception. Results show that anecdotes do not affect any of the variables. However, there is a positive relationship between curiosity and risk perception, and between trust in scientists and risk perception.
Translation in Yakutia as a Means of Preservation of the Sakha Language and Culture
Authors: Vasil’eva Akulina A.
Published: December 2021

Translation as a means of cross-cultural communication serves two purposes: 1. making an additional recording of cultural works of a certain people by creating a copy of these works in a language with a higher number of speakers for further introduction of the culture to a wider public; 2. in a situation of widespread bilingualism, preserving a vulnerable language against assimilation by a dominant language by a bilingual translators conscious counteracting of negative interference and their educational activities in the field of ecolinguistics. In comparison with translation from/to foreign languages, these translational purposes acquire other, new aspects when applied to the languages of the different peoples in one country, depending on the language situation, politics, etc. The article examines the practices used in achieving the above-mentioned purposes of Russian-Yakut, Yakut-Russian translation in the Sakha Republic (Yakutia), a constituent entity of the Russian Federation. The article also describes the role of translation in the spiritual culture of the Yakut people as a proxy of literary and artistic innovations capable of shaping and changing the artistic tastes of readers, as well as a means of integration into the world cultural space, enabling the Yakuts to look at their native culture from the point of view of native speakers of the Russian language and members of Russian (including Soviet) culture. Translation as a sphere of close interaction of languages is of interest to the language policy of this multinational constituent of the Russian Federation. With the adoption of federal and republican laws for language issues in the 1990s, the Sakha Republic (Yakutia) started to give more attention to the translation between the two official languages. As a result of years-long observation of bilingual Yakuts speech culture, it has become apparent that researching linguistical issues of translation, drawing up practical recommendations for translation based on scientific research, and then popularizing them among bilingual Yakuts may become a great help in the preservation of the native language. A review of the Sakha Republics (Yakutia) experience in translation development in a multinational constituent of the Russian Federation leads to a conclusion about the importance of the work of a translator (who translates from and to languages of Russia) in standardization of their native language. Such a translator can consciously regulate the mutual influence of the languages in society.
Oriental Ethnic Mind: Ways to Represent It in Translation from Buryat into Russian
Authors: Dashinimaeva Polina P.
Published: December 2021

The urgency and topicality of the research is due to an insufficient study of zoom-investigating into a pre- and post-translation mental stage, and of ways to identify or forecast the authors mind ethno-centered content. Hereby the objective of the study is to describe ways of representing the oriental ethnic mind in translation from Buryat into Russian. To implement it, the following tasks are solved: to prove the conceptual difference of the Buryat mind within three dimensions the experimental axiological data on the semantic space of three generations of modern Buryats are presented, the main vectors of oriental Buryat mind are determined, the given axiological observations are confirmed on the basis of a literary text material, the author being a conservatively orientally-minded author by himself, and a number of ways to represent the Buryat ethnic mind in translation into Russian are discussed, and their correlated correspondences (ir)relevance issue is respectively raised. The materials are as follows: the semantic differential experiment data and Dambinima Tsyrendashievs story Һuhlshyn uulzalga Last meeting. The research methods are a psycholinguistic experiment, a posttranslation analysis of the target text in Russian, an algorithm presentation of the source text ethnocentered semantics explication at the pre-translation stage which is presented in the conclusion.
Poetry by Louise Glück, translated by Ekaterina Dies: “Wanderer Persephone” from the Poetry Collection “Averno”
Authors: Markova Elena A.
Published: December 2021

In this paper weve tried to analyze the translation of L. Glck poem about Persephone (poetry collection Averno), carried out by Ekaterina Dais. A brief outline of literary work of Louise Glck is given. Using the method of hermeneutic commentary, the leitmotifs of her poetic and prose works are characterized. Understanding these motives is an important stage in the pre-text work, since the complex codes (often implicative) presented in poems about Persephone cannot be adequately deciphered without prior knowledge, and, therefore, it is not possible to evaluate the efforts of the translator, the tactics chosen by her. The material for the analysis is the poem Wanderer Persephone from the poetry collection Averno. Another goal of the article is to acquaint the Russian-speaking reader with the work of the original American poetess, which is currently reflected in the Russian scientific discourse.
Comparison of News Impacts on Sectoral Stock Returns during the COVID-19 Pandemic in Turkey
Authors: Tetik Metin
Published: December 2021

This study examines how the volatility of the sectoral stock returns within Borsa İstanbul are affected during the COVID-19 pandemic. The analysis uses daily stock return data for four main sector indices: services, finance, industry, and technology. The sample period of the study covers 03.03.2015–11.03.2021, and 12.03.2020-03.04.2021 is separately analyzed for the COVID-19 period. When E-GARCH models and news impact curves are analyzed, it is found that the services sector stock returns volatility differs from other sectoral stock returns.
Time-Varying Network Connectedness of G-7 Economic Policy Uncertainties: A Locally Stationary TVP-VAR Approach
Authors: Polat Onur
Published: December 2021

This work analyzes the frequency-dependent network structure of Economic Policy Uncertainties (EPU) across G-7 countries between January 1998 and April 2021. We implement an approach that builds dynamic networks relying on a locally stationary Time-Varying Parameter-Vector Autoregressive model using Quasi-Bayesian Local Likelihood methods. We compute short-, medium-, and long-term network connectedness of G-7 EPUs over a period covering several economic/financial turmoils. Furthermore, we structure short-term network topologies for the Global Financial Crisis (GFC) and the COVID-19 pandemic periods. Findings of the study indicate amplified interdependencies between G-7 EPUs around well-known economic/geopolitical incidents, frequency-dependent connectedness networks among them, and stronger interdependencies than the medium-, and long-term linkages. Finally, we find that short-term spillovers are not persistent in the long-term for both turmoil periods.
Economic and Monetary Integration in ECOWAS Countries: A Panel VAR Approach to Identify Macroeconomic Shocks
Authors: Ndongo Asta , Diop Ibrahima Thione
Published: December 2021

This paper studies the impact of output, exchange rate, price, and economic policies (fiscal and monetary) shocks to Economic Community of West African States (ECOWAS) economies over the period 1977-2019. The results of the impulse response functions obtained from the panel VAR show that monetary policy shocks stimulate economic activity, whereas fiscal shocks lead to a contraction. Moreover, these economic policy shocks lead to an increase in the price level. Finally, they have opposite effects on the real exchange rate: a monetary policy shock leads to an appreciation of national currencies against the US dollar, while a fiscal innovation leads to a depreciation of these currencies. As for exchange rate and price shocks, they create inflation and consequently a decline in economic activity. Furthermore, the forecast error variance decomposition reveals that real exchange rate shocks contribute the most to future fluctuations in macroeconomic variables in ECOWAS countries. Moreover, a comparison of the impact on the two currency areas, West African Economic and Monetary Union (WAEMU) and West African Monetary Zone (WAMZ), shows the degree of asymmetry between the two areas. The analysis shows, on the one hand, that shocks are more persistent and significant in the WAMZ and, on the other hand, that except for real exchange rate shocks, the two zones respond asymmetrically to shocks emanating from the other variables.