bluuebunny/crossref_metadata_2025 huggingface dataset:
Increased expression of androgen receptor and PSA genes in LNCaP (prostate cancer) cell line due to high concentrations of EGCG, an active ingredient in green tea
Authors: Bakhshandeh Nadereh , Mohammadi Maryam , Mohammadi Parisa , Nazari Elahe , Damchi Mehdi , Khodabandelu Sajad , Mokhtari Hossein
Published: December 2022

Objectives

Androgen receptor (AR) play a key role in the onset and progression of prostate cancer. Epigallocatechin-3-gallate (EGCG) is a polyphenolic compound and the active ingredient in green tea, which is involved in modulating gene expression through epigenetic alterations. Previous studies have shown that EGCG at low concentrations reduces the expression of AR and prostate-specific antigen (PSA) in the LNCaP cell line of prostate cancer. In this study, the effect of higher EGCG concentrations on AR and PSA expression in LNCaP prostate cancer cell line was investigated.

Methods

In this study, LNCaP prostate cancer cell line was used and after MTT test, concentrations of 40, 60 and 80 μg/mL EGCG were used for treatment. Then, the expression of AR and PSA genes was evaluated by RT-PCR. AR protein expression was also assessed by Western blotting.

Results

The present study showed that treatment of LNCaPs cells by EGCG reduces cell proliferation. The IC50 value was 42.7 μg/mL under experimental conditions. It was also observed that EGCG at concentrations of 40 and 80 μg/mL increased the expression of AR and PSA (p<0.05).

Conclusions

The present study showed that the effect of EGCG on AR expression was different at different concentrations, so that unlike previous studies, higher concentrations of EGCG (80 and 40 μg/mL) increased AR and PSA expression. It seems that due to the toxic effects of EGCG in high concentrations on cancer cells and the possibility of its effect on normal cells, more caution should be exercised in its use.
Numerical simulation and experimental research on cracking mechanism of twin-roll strip casting
Authors: Lv Zheng , Yang Zhou-Yi , Zhang Jian-Yu , Li Xue-Tong , Ji Peng , Zhou Qian , Zhang Xi-Liang , Shi Yin-Dong
Published: December 2022

Based on the three-dimensional field of molten pool and twin-roll strip casting experiments, this work verified the cracking mechanism of the strip by establishing mathematical model and rolling experiments. The results showed that due to the instability of the thermophysical field of the molten pool and the inconsistency of kiss curve height, the newly solidified strip will undergo incompatible deformation through the rolling. The stress concentration will appear around the large reduction area and then form slip bands. When plastic strain exceeds the limit of the metal, the oblique cracks will appear in the slip bands periodically or completely penetrate the strip. In addition, tensile cracks could also be produced by incompatible deformation. Therefore, keeping the uniformity and stability of the thermal physical field in molten pool is the key factor to restrain cracks.
Investigating system performance in 16 channel WDM network at minimum attenuation window for pre-defined input noise level
Authors: Debnath Pampa , Mondal Ujjwal , Deyasi Arpan
Published: December 2022

Input and output optical signal-to-noise ratio in 16-channel WDM network are investigated for predefined input noise level when design is set at minimum attenuation window. By keeping the input OSNR constant, gain and noise figure are computed along with SNR at both transmitting and receiving terminals for two different data rates and also with short-to-long range of trans-receiver distance. Corresponding variations of all the network properties, i.e., maximum Q-factor, eye height and noise figure are measured for estimation of performance degradation. Optimization in terms of both bit rate and channel distance is required, as evident from simulation result, for best possible system performance. Setting up of input noise level at 20 dBm indicates the fact of real-time compatibility with optimum value of output OSNR is revealed at a particular distance, which suggests the best result for communication system design.
Croatian (mor)phonotactic word-medial consonant clusters in the early lexicon
Authors: Kelić Maja , Matić Škorić Ana , Palmović Marijan
Published: December 2022

This study investigates the emergence of (mor)phonological consonant clusters in L1 acquisition. Following the Strong Morphonotactic Hypothesis (SMH), distribution and preferability of word-medial consonant clusters in the corpus of three children acquiring Croatian were explored. VCCV and VCCCV clusters were extracted from the Croatian Corpus of Child Language. Subsequently, all word-medial clusters were tagged as exclusively phonotactic, exclusively morphonotactic, and ones that occurred in both contexts. The results partially corroborated SMH, strengthening the premise that morphological richness of a language moderates the interaction between morphology and phonology in early language acquisition. The data showed a clear predominance of morphonotactic clusters in one out of three subcorpus. Developmentally, an increase in all three cluster types was observed and generally all clusters were predominantly less preferred. Early emerging phonotactic clusters appeared to be mostly preferred, while the first morphonotactic clusters comprised less preferred combinations, with a gradual increase in preferability. Individual differences in cluster distribution and preferability blurred the role of the importance of morphonotactic information in L1 acquisition, suggesting that children employ different paths to acquire a language, but also suggesting that further exploration of this hypothesis in different languages and using different approaches is needed.
Towards a better understanding of the economy and culture of the Late Bronze Age in the southeastern Baltic: Tarbiškės settlements
Authors: Piličiauskas Gytis , Vengalis Rokas , Minkevičius Karolis , Skridlaitė Gražina , Piličiauskienė Giedrė
Published: December 2022

In 2020, rescue excavations due to construction of a pipeline connecting Poland and Lithuania took place at the Bronze Age sites Tarbiškės 1 and Tarbiškės 2, eastern Lithuania, both dated to 1050–900 cal BC. They revealed a rather homogeneous archaeological assemblage which fills a gap in the development of the Bronze Age culture and economy in the southeastern Baltic. Tarbiškės Ware, from a typological as well as chronological point of view, stands in an intermediate position linking Trzciniec culture pottery with Žalioji and Early Striated Wares. Macrobotanical analysis of charred plant remains revealed that Bronze Age people at Tarbiškės cultivated Panicum miliaceum, Hordeum vulgare and Triticum sp. The Tarbiškės sites demonstrate that early farmers used to settle areas at higher elevations with sandy soils, further from large bodies of water. They used flint and other stone tools widely and lacked bronze. Tarbiškės is the first and
only ancient settlement discovered in Lithuania with a workshop for on-site manufacturing of polished stone axes with drilled holes.
Maximizing Strength: The Stimuli and Mediators of Strength Gains and Their Application to Training and Rehabilitation
Authors: Spiering Barry A. , Clark Brian C. , Schoenfeld Brad J. , Foulis Stephen A. , Pasiakos Stefan M.
Published: December 2022

Spiering, BA, Clark, BC, Schoenfeld, BJ, Foulis, SA, and Pasiakos, SM. Maximizing strength: the stimuli and mediators of strength gains and their application to training and rehabilitation. J Strength Cond Res XX(X): 000–000, 2022—Traditional heavy resistance exercise (RE) training increases maximal strength, a valuable adaptation in many situations. That stated, some populations seek new opportunities for pushing the upper limits of strength gains (e.g., athletes and military personnel). Alternatively, other populations strive to increase or maintain strength but cannot perform heavy RE (e.g., during at-home exercise, during deployment, or after injury or illness). Therefore, the purpose of this narrative review is to (a) identify the known stimuli that trigger gains in strength; (b) identify the known factors that mediate the long-term effectiveness of these stimuli; (c) discuss (and in some cases, speculate on) potential opportunities for maximizing strength gains beyond current limits; and (d) discuss practical applications for increasing or maintaining strength when traditional heavy RE cannot be performed. First, by conceptually deconstructing traditional heavy RE, we identify that strength gains are stimulated through a sequence of events, namely: giving maximal mental effort, leading to maximal neural activation of muscle to produce forceful contractions, involving lifting and lowering movements, training through a full range of motion, and (potentially) inducing muscular metabolic stress. Second, we identify factors that mediate the long-term effectiveness of these RE stimuli, namely: optimizing the dose of RE within a session, beginning each set of RE in a minimally fatigued state, optimizing recovery between training sessions, and (potentially) periodizing the training stimulus over time. Equipped with these insights, we identify potential opportunities for further maximizing strength gains. Finally, we identify opportunities for increasing or maintaining strength when traditional heavy RE cannot be performed.
THE EFFECT OF STORAGE TIME ON THE ANTIOXIDANT ACTIVITY AND POLYPHENOLIC PROFILE OF FROZEN AND LYOPHILIZED DRONE BROOD FIXED IN HONEY
Authors: SIDOR EWELINA , TOMCZYK MONIKA , MIŁEK MICHAŁ , DŻUGAN MAŁGORZATA
Published: December 2022

Background. The purpose of the study was to evaluate the effect of drone brood fixation in rape honey and to analyze changes in its antioxidant activity during storage. The fixation was carried out for frozen and lyophilized drone brood, which were mixed with honey in various proportions (1, 2, and 4 % w/w). The antioxidant activity (DPPH and FRAP methods) and the total content of polyphenolic compounds (TPC) after 3, 6, and 9 months of storage were analyzed. After 9 months of storage, the polyphenolic profile (HPTLC method) and physicochemical parameters of samples were assessed. Results and conclusion. The addition of drone brood to honey increased the antioxidant activity of the final product considerably (by 33 to 110 %), while only slightly affected the physicochemical parameters (conductivity and a diastase number) compared to control honey. Moreover, honey with the addition of drone brood still continued to meet the requirements for honey standard. The polyphenol profile obtained by HPTLC method for honey with the addition of drone brood was enriched mainly with ellagic and ferulic acids compared to control honey. It was found that fixing the drone brood in honey allows to maintain its antioxidant properties for 6 months, whereas a significant decrease in reducing power (FRAP) and polyphenolic content (TPC) during prolonged storage were observed (from 8 to 26 % ). Due to the fact that lower losses were observed for the addition of frozen than for lyophilized drone brood after 9 months of storage, preserving the frozen brood in honey (up to 5 % w/w) can be recommended as an effective and inexpensive method available in apiary conditions.
Radiological features of aspergillomas and surrounding areas after pulmonary tuberculosis
Authors: Jiayi Chen , Jia Chen , Dong Zhang , Li Chai
Published: December 2022

Objectives:

Although pulmonary tuberculosis (TB) may be effectively treated, destruction of the lung parenchyma can lead to recurrent infections including aspergilloma. Hemoptysis is a serious complication of aspergilloma. However, the relationship between aspergillomas and surrounding areas after TB has not been comprehensively investigated. Herein, CT scans were used as the primary method of investigation.

Methods:

A retrospective study on patients with aspergilloma was performed. Twenty patients with prior tuberculosis infections were compared with 27 individuals who had never been infected with tuberculosis. The Mann-Whitney U-test was used for direct comparison of aspergilloma volume and cavity thickness between the TB group and the non-TB group. Fisher’s exact test was used to compare aspergilloma calcification and location; perilesional ground-glass opacity (GGO), calcification, and bronchiectasis; and pleural thickening between groups. To facilitate the localization of aspergilloma, the apical and posterior segments of the upper lobe or the superior segment of the lower lobe were defined as “the golden area.”

Results:

A total of 76.60% patients (36/47) had a history of hemoptysis, and 13.89% (5/36) had previously experienced severe hemoptysis. Patients who had hemoptysis-associated events were significantly more likely to have considerable perilesional GGO around the aspergilloma than those who did not experience such events (77.78% vs 36.36%, P=.027). In the TB group, all aspergillomas were situated in “the golden area” (100.00% vs 77.78%, P=.031). However, no statistically significant differences were observed in aspergilloma amount or volume, or the thickness of the cavity between groups (P >.05). Furthermore, no significant differences were observed between groups regarding aspergilloma calcification, perilesional GGO, perilesional calcification, perilesional bronchiectasis, or pleural thickening (P >.05).

Conclusions:

Hemoptysis caused by aspergilloma is frequently encountered in clinical settings, and the presence of perilesional GGO on CT images is strongly suggestive of hemoptysis. Patients with prior tuberculosis often have aspergillomas located in “the golden area.” Images obtained from CT scans may be used to guide therapy.
Effect of dopant concentration Mn in SnO2 nanoparticles on photocatalytic, magnetic and optical properties
Authors:   Department of Physics, Presidency College, Chennai – 600 005, India, Renuga R. , Srinivasan S. ,   Department of Physics, Presidency College, Chennai – 600 005, India, Thangeeswari T. ,   Department of Physics, Vel Tech Multitech Engineering College, Chennai-600 062, Tamilnadu, India, Sureshc S. ,   Department of Physics, Saveetha Engineering College (Autonomous), Thandalam, Chennai -602105, Tamil Nadu, India, Priyadharshini E. ,   Department of Physics, Jaya Engineering College, Thiruninravur, Tamil Nadu, India, Bomila R. ,   Department of Physics, Valliammai Women’s College, Thirkovilur, Tamil Nadu, India
Published: December 2022

Mn doped SnO2 nanoparticles were synthesized in a sol-gel technique at various concentrations. A wide range of properties are analyzed by using X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy with energy dispersive spectroscopy (SEM with EDAX), Transmission Electron Microscopy (TEM), UV-Visible spectroscopy, photoluminescence spectroscopy (PL), Vibrating Sample Magnetometer (VSM), and photocatalytic studies. Results from EDAX confirmed the presence of Sn and Mn ions in SnO2 nanoparticles doped with Mn. As a result of analyzing the luminescence of all synthesized samples, blue emission characteristic of lighting applications was observed. Furthermore, 0.2M Mn doped SnO2 sample shows the enhanced ferromagnetism at room temperature with elevated saturation magnetization value. The 0.2M Mn doped SnO2 nanoparticles show the significant increase in photocatalytic efficiency of SnO2 among the other doped samples. Thus, all experiment results demonstrated that the concentration of dopant influences the structure, optical properties, photocatalytic properties, and magnetic properties of SnO2.
The structural and electrical properties of polyaniline carbon nanotubes (PANI-CNTs) composite
Authors:   Department of Physics Bahauddin Zakariya University, Multan 60800, Pakistan, Anwar N. , Niaz N. A. ,   Department of Physics Bahauddin Zakariya University, Multan 60800, Pakistan, Shakoor A. ,   Department of Physics Bahauddin Zakariya University, Multan 60800, Pakistan, Qasim M. ,   Department of Physics, University of Gujarat, Pakistan, Ahmad M. ,   Department of Physics Bahauddin Zakariya University, Multan 60800, Pakistan
Published: December 2022

Carbon nanotubes (CNTs) doped polyaniline (PANI) nanocomposite was synthesized by chemical polymerization method in the presence of HCl medium. The structure of the PANI/CNTs composite was confirmed by X-ray diffraction (XRD) technique. The SEM results showed granular and tube like shape for PANI and CNTs respectively. The SEM characterization of PANI-CNTs composite revealed a uniform wrapping of CNTs by PANI forming a core-shell nanostructure. The temperature dependent dielectric measurements were performed in the frequency range of 0.1 kHz-1 MHz. Dielectric measurements revealed the strong interactions between PANI and CNT nanoparticles causing a beneficial effect on stability of the composites. The dielectric constant followed the Maxwell-Wagner interfacial polarization. The frequency dependent conductivity obeyed a power law of frequency. Temperature has an effect on dielectric constant values of composite sample. Heat treatment affected the dipole polarization by reducing the relaxation time and hence contributed to the enhancement of dielectric parameters. Dielectric properties of composites were found to be improved due to addition of carbon nanotubes, which can improve the formation of a more efficient network for charge transport mechanism in the base polyaniline matrix. The border between polyaniline and CNTs can play an important role in yielding a large dielectric constant in the nanocomposites.
Sensor NLR immune proteins activate oligomerization of their NRC helpers in response to plant pathogens
Authors: Contreras Mauricio P , Pai Hsuan , Tumtas Yasin , Duggan Cian , Yuen Enoch Lok Him , Cruces Angel Vergara , Kourelis Jiorgos , Ahn Hee‐Kyung , Lee Kim‐Teng , Wu Chih‐Hang , Bozkurt Tolga O , Derevnina Lida , Kamoun Sophien
Published: December 2022

Nucleotide‐binding domain leucine‐rich repeat (NLR) immune receptors are important components of plant and metazoan innate immunity that can function as individual units or as pairs or networks. Upon activation, NLRs form multiprotein complexes termed resistosomes or inflammasomes. Although metazoan paired NLRs, such as NAIP/NLRC4, form hetero‐complexes upon activation, the molecular mechanisms underpinning activation of plant paired NLRs, especially whether they associate in resistosome hetero‐complexes, is unknown. In asterid plant species, the NLR required for cell death (NRC) immune receptor network is composed of multiple resistance protein sensors and downstream helpers that confer immunity against diverse plant pathogens. Here, we show that pathogen effector‐activation of the NLR proteins Rx (confers virus resistance), and Bs2 (confers bacterial resistance) leads to oligomerization of their helper NLR, NRC2. Activated Rx does not oligomerize or enter into a stable complex with the NRC2 oligomer and remains cytoplasmic. In contrast, activated NRC2 oligomers accumulate in membrane‐associated puncta. We propose an activation‐and‐release model for NLRs in the NRC immune receptor network. This points to a distinct activation model compared with mammalian paired NLRs.
Throttling Effect on the Performance and Emissions of a Multi-Cylinder Gasoline Fuelled Spark Ignition Engine
Authors: Hamada Khalaf Ibrahim , Rahim M. F. , Rahman M. M. , Bakar R. A.
Published: December 2022

The throttle mechanism, a regulatory technique of engine output, is accompanied by a loss of some energy. The effect of intake air throttling on the performance and emissions of a multi-cylinder spark ignition gasoline engine was experimentally investigated. The engine was coupled to a hydraulic dynamometer equipped with a customized cooling system for both the engine and dynamometer. Experimental tests were performed for various engine speeds and air-fuel ratios at the WOT and POT conditions with optimized ignition timing. The acquired results recorded that a better engine operation could be achieved with WOT in terms of bmep, bsfc, ηb, CO, CO2 and UHC compared to POT. At the same time, the worst trend at WOT was noticed for the NOx concentration due to the higher conversion efficiency of fuel combustion. In terms of engine speed for both WOT and POT conditions, operating at 3000 rpm represents the minima of ϕ, bsfc, CO and UHC; and the maxima of ηb, CO2 and NOx with some fluctuation on both sides of this point. Maximum recorded values of ηb were about 30.55% and 28. 55%, while the minimum values of bsfc were about 274 and 293 g/kW.h for the WOT and POT conditions, respectively. The maximum bmep was obtained at 2500 rpm at WOT and POT conditions with values of about 940 kPa and 904 kPa, respectively. Maximum recorded values of NOx were about 1525 and 977 ppm for the WOT and POT conditions, respectively.
The Effect of Wearing Soccer Headgear on the Head Response in Soccer Heading
Authors: Tan Fu Yang , Hassan Mohd Hasnun Arif , Johari Nasrul Hadi , Omar Mohd Nadzeri , Hasanudin Iskandar
Published: December 2022

Soccer is regarded as the most popular sport in the world, with millions of people actively involved in the game. Being a contact sport in nature, soccer players are susceptible to various kinds of injuries, such as lower extremities muscle injury. In addition to those familiar injuries that soccer players sustain during the game, traumatic brain injury is also a possibility. Head impacts in soccer could be a result of head-to-head impact with an opponent player, a head-to-elbow impact, an impact with the goal post, an impact with the ground, as well as an impact with the soccer ball, which occurs during a heading manoeuvre. Soccer allows the players to use their heads to hit the ball to pass it to a teammate or even perform heading to score a goal. Although soccer heading is perceived as less harmful as compared to head impacts with other hard objects, many studies have shown compelling evidence that this repetitive heading might harm the brain, thereby leading to traumatic brain injury. Protective headgears designed especially for soccer players have been commercially available in the market for some years. However, the effectiveness of these headgears in reducing the impact due to soccer heading has not been well studied. This paper investigates the effectiveness of two commercially available headgears, the Full90 and the ForceField headgear by means of a heading experiment. An anthropometric test device known as Hybrid III head and neck dummy instrumented with an inertial sensor that consists of a triaxial accelerometer and gyroscope installed at the centre of gravity of the head was used in the experiment. A soccer ball launching machine was used to propel the ball at several inbound velocities. Peak linear acceleration (PLA) and peak angular acceleration (PRA) were recorded, and the head injury criterion (HIC) and the rotational injury criterion (RIC) were calculated. It was found that both headgears failed to reduce the linear components of head acceleration but instead increased the HIC (13 – 66% increment) depending on the inbound ball velocity. With respect to the rotational component of head injury, the Full90 headgear was found to reduce the RIC up to 29%, but the ForceField failed to provide a significant reduction of RIC. Overall, both headgears were found to be ineffective in reducing linear and rotational components of head injury, which could be attributed to the headgear design. Improved headgear design and an improved padded foam are needed to protect soccer player’s brain while performing soccer heading.
Poles’ Attitudes to the Concept of Whistleblowing. Historical and Present Background
Authors: Kun-Buczko Magdalena
Published: December 2022

The issue of whistleblowers is one of great interest and controversy because of EU Directive (EU) 2019/1937 of the European Parliament and of the Council of 23 October 2019 on the protection of persons who report breaches of Union law. While the English meaning of “whistleblowing” is inherently positive and not associated with anything negative, the Polish translation of the word, “sygnalista”, often does not evoke positive associations. Blowing the whistle versus snitching are two types of activity and it is important to understand the essence of these terms. Unfortunately, the linguistic connotations indicate that Poles do not always read the proper intentions when hearing the word “whistleblower”. Whistleblowing is often seen in Poland as a reprehensible activity, and whistleblowers are usually referred to as denouncers. The meaning of the word “whistleblower” in Poland is rather pejorative. European history, experienced through Nazi practices, the spying age of the Cold War and invigilation by the Soviet Union, has developed firmly established hostility against so-called informers. That is why it is so difficult to attain a level of positive understanding of the meaning of this word in Poland. The current realities of operating an organization, regardless of its legal nature, force it to conform to certain standards. These standards, arising either from legal norms or good practice, form the so-called compliance system. Regulations on whistleblowing are inevitably part of it.
ПОВОЄННЕ ВІДНОВЛЕННЯ УКРАЇНИ В КОНТЕКСТІ ФРАГМЕНТАЦІЇ СВІТОВОЇ ЕКОНОМІКИ
Authors: ПЛОТНІКОВ Олексій
Published: December 2022

Досліджено питання сучасного світового розвитку з огляду на російську воєнну агресію проти України. Охарактеризовано світові тенденції щодо фрагментації на противагу попереднім глобалізаційним тенденціям. Глобалізаційні процеси продовжують існувати у світі, але в умовах регіональних і покраїнових обмежень. Ще напередодні 2020-х років світова економічна думка дискутувала щодо перспектив розвитку в умовах так званої слоубалізації (повільної глобалізації). Активне використання режиму санкцій визначає окремі країни не лише як не сприятливі для економічної діяльності, а й як такі, що фактично виключені з процесу глобалізації. Відбуваються реальні зміни центрів економічної могутності. Нині дедалі активніше йдеться про теоретичну і практичну фрагментацію. Фактично у світі відбуваються процеси посилення економічної фрагментації, що виступає противагою традиційним глобалізаційним процесам. Фрагментація є одним з вагомих наслідків російської збройної агресії проти України і має перспективи призвести до поділу світу на геополітичні блоки із своїми власними технічними стандартами, резервними валютами і системами платежів.
Визначено, що перспективи повоєнної відбудови України відбуватимуться в умовах фрагментації світової економіки і реалізовуватимуться за відповідними параметрами. Україна і надалі залежатиме від зовнішніх джерел фінансування і матеріальної допомоги. У цьому контексті вкрай актуальним є збереження зовнішніх пріоритетів розвитку країни, у першу чергу набуття повноцінного членства в Європейському Союзі. Важливо також усвідомити роль держави в економічному житті в умовах війни і в період післявоєнної відбудови. Крім того, беззаперечною повинна бути максимальна коректність у відносинах з іноземними партнерами, зокрема, у питаннях розрахунку потреб України у фінансуванні процесу відбудови з огляду на відмінності в ставленні до проблем корупції в Україні й країнах Заходу.
ПРО ЗАГАЛЬНУ І СПЕЦІАЛЬНІ ТЕОРІЇ ЦІННОСТІ
Authors: ТАРАСЕВИЧ Віктор
Published: December 2022

Ретроспективно розглянуто класичні й новітні концепції і теорії вартості й цінності. Акцентовано на синтетичних і фундаментальних розробках, необхідності їх розвитку з огляду на випереджальну експансію сфери олюднення. Висунуто гіпотезу про всезагальність і складність ціннісних відносин. Визначено їх філософсько-загальнонауковий і економічний зміст. Ціннісні відносини (цінність) представлено як складну систему суб’єкт-суб’єктних відносин з приводу взаємопов’язаних і економічно значимих для суб’єктів відповідностей: а) між суб’єктивним образом реального об’єкта й самим реальним об’єктом, у тому числі між різними елементами першого, з одного боку, і різними елементами останнього – з іншого; б) між різними елементами суб’єктивного образа реального об’єкта; в) між різними елементами реального об’єкта. Зазначена система є ядром фундаментальної теоретичної моделі (схеми) цінності. Охарактеризовано кориснісну і витратнісну складові цінності, а також тріалектику її загального, особливого й унікального. Загальна складова цінності притаманна всім ерам і епохам розвитку людства, особлива – окремим епохам і сферам діяльності, унікальна – окремим способам виробництва. Розроблено темпоральний простір загальної теорії цінності в координатах результатів діяльності, сфер і атрибутів, вимірів, а також історичних рамок діяльності й цінності. Показано позиціювання в ньому теорії трудової вартості. Розглянуто історичну коеволюцію діяльності й цінності в контексті співіснування та зміни ер і епох розвитку людства. Запропоновано концептуальну і фундаментальну теоретичну схему загальної теорії цінності. Ядра спеціальних теорій цінності набувають статусу часткових теоретичних схем загальної теорії цінності. Зроблено висновок про необхідність каталізації наукових пошуків тих нових спеціальних теорій цінності, які здатні адекватно описати й пояснити ціннісні відносини в олюдненні (опосередкованому, безпосередньому і в цілому), в тому числі у створенні знаннєвих і знаннєво-інформаційних продуктів
EFL PRE-SERVICE TEACHERS’ EXPERIENCES IN DESIGNING TPACK -BASED INSTRUCTIONAL VIDEOS
Authors: Putri Istifa , Susilo Susilo , Rachmawaty Noor
Published: December 2022

ABSTRACTThe article analyzed pre-service teachers’ experiences in designing and implementing instructional videos based on the TPACK framework in their microteaching course. This was a qualitative study in which nine students of English teacher education (i.e., preservice teachers) were the participants who learned to design and implement instructional videos in their micro-teaching course. The data were extracted from the results of the interview and document analyses on their instructional videos made in microteaching class together with other 29 students participating in the class. The data were analyzed by using the interactive model proposed by Miles et al. (2014). The result showed that pre-service teachers had various self-reflections in the experiences of designing and implementing the instructional videos based on the TPACK framework, putting into three phases of steps in design-making and product-implementing. The pre-service teachers’ inadequacies in having the TK and CK caused difficulties in designing the instructional videos in general. Moreover, the pre-service teachers coped with numerous challenges, both personally and technically. Finally, this finding is advisable for 21st-century teacher candidates who should integrate technology into teaching in that they should be technology-alert in any circumstance of teaching.ABSTRAKArtikel ini menganalisis pengalaman calon guru dalam merancang dan mengimplementasikan video instruksional berdasarkan kerangka kerja TPACK dalam kursus microteaching mereka. Ini adalah studi kualitatif di mana sembilan siswa pendidikan guru bahasa Inggris (yaitu, calon guru) adalah peserta yang belajar merancang dan mengimplementasikan video instruksional dalam kursus micro-teaching mereka. Data diambil dari hasil wawancara dan analisis dokumen pada video instruksional mereka yang dibuat di kelas microteaching bersama dengan 29 siswa lain yang berpartisipasi di kelas tersebut. Data dianalisis dengan menggunakan model interaktif yang diusulkan oleh Miles et al. (2014). Hasil penelitian menunjukkan bahwa calon guru memiliki berbagai refleksi diri dalam pengalaman merancang dan mengimplementasikan video pembelajaran berdasarkan kerangka TPACK, menempatkan ke dalam tiga fase langkah dalam pembuatan desain dan implementasi produk. Kekurangan guru prajabatan dalam memiliki TK dan CK menyebabkan kesulitan dalam merancang video pembelajaran secara umum. Selain itu, calon guru menghadapi berbagai tantangan, baik secara pribadi maupun teknis. Akhirnya, temuan ini disarankan untuk calon guru abad ke-21 yang harus mengintegrasikan teknologi ke dalam pengajaran karena mereka harus mewaspadai teknologi dalam segala situasi pengajaran.How to Cite: Putri I., Susilo, Rachmawaty, N.(2022). EFL Pre-Service Teachers’ Experiences in Designing TPACK -Based Instructional Videos . IJEE (Indonesian Journal of English Education), 9(2), 334-357. doi:10.15408/ijee.v9i2.27447
EXPLORING STUDENTS’ INTERESTS AND CHALLENGES IN WRITING FICTION IN CREATIVE WRITING CLASS
Authors: Dewi Utami , Siregar Fitri Rayani
Published: December 2022

ABSTRACTThis article explored students' interests and challenges in writing fiction in EFL creative writing classes. The study used a qualitative approach involving 43 college students studying creative writing as the subjects of the study. Research instruments for this study were questionnaires and interviews, the first of which asked students what genres of fiction they were interested in, and the second confirmed their motivations in writing the fiction genre and their challenges in writing fiction. Data from questionnaires were analysed using percentages, while data from the interviews were analysed using thematic analysis (Braun & Clarke, 2006). Findings of the study revealed that (1) most students (53.5%) were interested in and preferred writing romance fiction, and (2) most students experienced challenges in writing short stories including difficulties in developing an exciting story, deciding on a plot and elaborate dialogues, and defining the characters in the story.ABSTRAKPenelitiaan ini mengeksplorasi minat dan tantangan mahasiswa dalam menulis fiksi di kelas menulis kreatif EFL. Penelitian ini menggunakan pendekatan kualitatif dengan melibatkan 43 mahasiswa yang mempelajari penulisan kreatif sebagai subjek penelitian. Instrumen penelitian untuk penelitian ini adalah kuesioner dan wawancara, yang pertama menanyakan kepada siswa genre fiksi apa yang mereka minati, dan yang kedua mengkonfirmasi motivasi mereka dalam menulis genre fiksi dan tantangan mereka dalam menulis fiksi. Data hasil kuesioner dianalisis dengan persentase, sedangkan data hasil wawancara dianalisis dengan analisis tematik (Braun & Clarke, 2006). Temuan penelitian ini mengungkapkan bahwa (1) sebagian besar siswa (53,5%) tertarik dan lebih suka menulis fiksi roman, dan (2) sebagian besar siswa mengalami tantangan dalam menulis cerita pendek termasuk kesulitan dalam mengembangkan cerita yang menarik, menentukan plot dan dialog yang terperinci, dan mendefinisikan karakter dalam cerita.How to Cite: Dewi, U., Siregar, F. R. (2022). Exploring Students’ Interests and Challenges in Writing Fiction in Creative Writing Class. IJEE (Indonesian Journal of English Education), 9(2), 359-371. doi:10.15408/ijee.v9i2.28372
ENGLISH STUDENT-TEACHER AWARENESS OF DIFFERENTIATED INSTRUCTION (DI) IMPLEMENTATION IN CLASSROOM
Authors: Rahmani Eka Fajar , Riyanti Dwi
Published: December 2022

ABSTRACTThis study aimed to examine the understanding of English Education Department student-teachers on the use of differentiated instruction (DI) in the classroom. There were 80 student-teachers, 20 (25%) male and 60 (75%) female. The data were collected primarily through a 31-item questionnaire with four scales ranging from "not important" to "very important." The questionnaire responses were analyzed to determine the amount of DI awareness and importance. The data underwent descriptive analysis (statistical analysis) by comparing the mean score (M) and standard deviation (SD) of each item for the level of awareness and by calculating percentages for the level of importance. The results indicated that the student-teachers awareness of DI implementation ranges from "high" with the lowest score of 2.06 (2.06>2.01-3.00) to "very high" with the highest score of 3.71 (3.71>3.01-4.00). Consequently, the level of importance concurred with or supported the awareness result that the participants regarded DI to be important, ranging from "somewhat important" (49.40%) to "very important" (88.39%). These findings suggest good implications for the pedagogical element of student-teacher knowledge of DI implementation in the classroom. ABSTRAKPenelitian ini bertujuan untuk menginvestigasi kesadaran mahasiswa PLP Pendidikan Bahasa Inggris tentang penerapan pembelajaran berdifferensiasi (DI) di kelas. Ada 80 mahasiswa PLP, 20 (25%) laki-laki dan 60 (75%) perempuan. Data dikumpulkan melalui kuesioner dengan empat skala mulai dari "not implotant" hingga "strongly important" yang berjumlah 31 item. Data dianalisis secara deskriptif analisis (analisis statistik) dengan membandingkan nilai rata-rata (M) dan standar deviasi (SD) masing-masing item untuk tingkat kesadaran dan dengan menghitung persentase untuk tingkat kepentingan. Hasil penelitian menunjukkan bahwa kesadaran mahasiswa PLP terhadap penerapan DI berkisar antara "tinggi" dengan skor terendah 2,06 (2,06>2,01-3,00) hingga "sangat tinggi" dengan skor tertinggi 3,71 (3,71>3,01-4,00). Hasil tersebut sejalan dengan hasil tingkat kepentingan bahwa peserta menganggap DI penting, mulai dari "agak penting" (49,40%) hingga "sangat penting" (88,39%). Temuan ini menunjukkan implikasi yang baik untuk elemen pedagogis pengetahuan mahasiswa PLP implementasi DI di kelas. How to Cite: Rahmani, Eka F., Riyanti, D. (2022). English Student-Teacher Awareness of Differentiated Instruction (DI) Implementation in Classroom. IJEE (Indonesian Journal of English Education), 9(2), 192-210. doi:10.15408/ijee.v9i2.28505
ARGUMENTATIVE WRITING CONSTRUCTION OF EFL WRITING CLASS THROUGH DECLARATIVE SPEECH ACTS APPROACH
Authors: Nasihah Durotun , Elfiyanto Sonny
Published: December 2022

ABSTRACTThis study investigates how Indonesian undergraduate EFL students construct argumentative essays through critical discussion using Declarative speech acts and pragmatic approaches. This study employed a qualitative research method. The data consist of argumentative essays authored by undergraduate students majoring in English at a private university in Indonesia (N=34). Students worked in pairs to discuss a controversial topic, separated into protagonist and antagonist groups. The analysis showed that students used four steps of argumentation: confrontation, opening, argumentation, and conclusion. Most students used confrontation and opening stages in the introduction, argumentation stage in developing a paragraph, and end with a conclusion. To understand the purpose of argumentation, the students used four types of speech acts, which have different functions: assertive, commissive, declarative, and directive speeches. Implementing the declarative speech acts theory helps the students comprehend argumentative writing and trains them to have good critical thinking in resolving different opinions. ABSTRAKPenelitian ini mengkaji bagaimana siswa EFL Indonesia menuliskan esai argumentatif melalui diskusi kritis dengan menggunakan pendekatan pragma-dialektika Van Eemeren dan Grootendorst (1970) dan pragmatis Searle (1969). Penelitian ini menggunakan metode kualitatif. Data berasal dari esai argumentatif semester ketiga yang ditulis oleh mahasiswa Indonesia di jurusan bahasa Inggris. Tiga puluh empat siswa di kelas menulis mendiskusikan topik yang berbeda. Siswa bekerja berpasangan untuk mendiskusikan topik kontroversial, dipisahkan menjadi kelompok protagonis dan antagonis. Analisis mengklaim bahwa siswa menggunakan empat langkah argumentasi: konfrontasi, pembukaan, argumentasi, dan kesimpulan. Penelitian ini menemukan bahwa sebagian besar siswa menggunakan tahap konfrontasi dan pembukaan dalam pendahuluan, tahap argumentasi dalam mengembangkan paragraf, dan diakhiri dengan kesimpulan. Untuk mengetahui tujuan penggunaan argumentasi, siswa menggunakan empat tindak tutur, yang memiliki fungsi berbeda: asertif, komisif, deklaratif, dan direktif. Menerapkan teori pragma-dialektika membantu siswa memahami tulisan argumentatif dan melatih mereka untuk memiliki pemikiran kritis yang baik dalam menyelesaikan pendapat yang berbeda.How to Cite: Nasihah, D., Elfiyanto, S. (2022). Argumentative Writing Construction of EFL Writing Class Through Declarative Speech Acts Approach. IJEE (Indonesian Journal of English Education), 9(2), 192-210. doi:10.15408/ijee.v9i2.28522
Quality Improvement Initiative to Improve Timing of Enteral Feeds in Pediatric Acute Pancreatitis
Authors: Templeton Kate , Chan Yuen Jenny , Lenz Caitlin , Mann Alison R. , Friedler Haley S. , Yim Ramy , Alfieri Maria , Starmer Amy J. , Grover Amit S.
Published: December 2022

BACKGROUND

Acute pancreatitis (AP) represents a significant disease burden in the pediatric population. The management of AP includes fluid resuscitation, pain management, and early enteral feeds. Contrary to old dogma, early enteral feeding has been shown to improve outcomes and reduce hospital length of stay (LOS), yet uptake of this approach has not been standardized. Our aim was to standardize the management of AP, increasing the percentage of patients receiving early enteral nutrition from 40% to 65% within 12 months.

METHODS

Between January 2013 and September 2021, we conducted a quality improvement initiative among patients hospitalized with AP. Interventions included the development of a clinical care pathway, integration of an AP order set, and physician education. Our primary outcome was the percentage of patients receiving enteral nutrition within 48 hours of admission, and our secondary outcome was hospital LOS. Balancing measures included hospital readmission rates.

RESULTS

A total of 652 patients were admitted for AP during the project, of which 322 (49%) were included after pathway implementation. Before pathway development, the percentage of patients receiving early enteral nutrition was 40%, which increased significantly to 84% after our interventions. This improvement remained stable. Median LOS decreased significantly from 5.5 to 4 days during this timeframe. Our balancing measure of readmission rates did not change during the project period.

CONCLUSIONS

Through multiple interventions, including the implementation of an AP clinical pathway, we significantly increased the proportion of patients receiving early enteral nutrition and decreased hospital LOS without increasing hospital readmission rates.
Entering the Stream to Enlightenment: Experiences of the Stages of the Buddhist Path in Contemporary Sri Lanka
Authors: Sirimane Yuki
Published: December 2022

This book is a study on the nature and effects of the Theravāda Buddhist religious experiences of the four supramundane fruits of the Noble Eightfold Path – the experience of the fruit which is stream-entry, once returning, non-returning and Arahanthship – with special focus on the experience of stream-entry. It represents the first time within Theravāda Buddhist studies that a serious textual study has been combined with a substantial field research. Despite disciplinary rules which virtually prohibit a monk with higher ordination from discussing their personal religious experiences, this book presents seven comprehensive anonymous interviews conducted mainly with forest monks on their meditative experiences. The study presents a definition for the ‘supramundane fruit’ of the path and an alternate framework to discuss and evaluate Theravāda Buddhist religious experiences. It then uses this framework to address some longstanding debates around the Theravāda path and its fruits thus bringing experience back to the centre stage of these debates.
The Choice of Product for Mixed or Formula Feeding of Infant: Beneficial Properties of Goat’s Milk Formula
Authors: Belyaeva Irina A. , Bombardirova Elena P. , Turti Tatiana V.
Published: December 2022

This review summarizes the benefits of goat’s milk as the basis to produce adapted milk formulas according to relevant infants feeding issues. The characteristics of main nutrients of modern goat’s milk formulas are presented. A balanced protein composition enriched with [1]-palmitate, presence of prebiotics-oligosaccharides, natural nucleotides and probiotics advances these formulas closer to breast milk and provide their multipotent sanogenetic effects. The unique composition of goat’s milk formulas allows to ensure normal physical growth of a baby, induces tissue and systemic immunity via adequate intestinal microbiota formation, maintains normal functioning of gut-brain axis, that promotes vegetative and visceral disorders (due to functional digestive disorders) correction. Thus, it is possible to recommend goat’s milk formulas in cases of forced mixed or formula feeding of healthy infants and children with functional digestive disorders.
The Appearance and Establishment of Breastfeeding Amongst Mammals: From Echidna and Platypus to Human
Authors: Ukraintsev Sergey E. , Samal Tatiana N.
Published: December 2022

The paper provides review of the scientific literature dedicated to the evolutionary aspects of breastfeeding in the animal kingdom. Differences in breast milk composition amongst different mammals along with changes in breast milk composition during evolution provided. Special attention is paid to oligosaccharides — unique components of the breast milk of Homo sapiens.
A COMPARATIVE STUDY ON THE OIL RECOVERY PERFORMANCE OF THE CO2 AND N2 HUFF-N-PUFF PROCESSES IN LOW PERMEABILITY CORES
Authors: Jiang Luming , Shu Yong , Ma Nianhao , Li Yingge , Du Dongxing
Published: December 2022

The gas huff-n-puff process has been widely employed in low permeability reservoir development practices. At present, the understanding of synergistic effects of different injection fluids and rock permeability is still limited and is worthy of in-depth investigation. Therefore, laboratory studies on oil recovery performance of supercritical CO2 (scCO2) and N2 huff-n-puff processes in ultra-low (< 0.5 mD), extra-low (0.5-1 mD), and average-low permeability (1-10 mD) core samples were systematically investigated. More effective cycles could be achieved in the CO2 huff-n-puff process than in the N2 process. The CO2 huff-n-puff operation could produce 29.9% oil in the ultralow permeability core, which is obviously higher than 20.2% for N2. With increasing core permeability, the oil recovery ratio for both the scCO2 and N2 huff-n-puff processes increases as well. Laboratory results show oil recovery ratios of 33.1% and 47.3% for the scCO2 process in 0.5 mD and 10 mD cores and 36.3% and 49.1% for the N2 process in 0.5 mD and 9.5 mD cores, respectively. Although the oil recovery rates for the N2 and CO2 huff-n-puff processes are close in the 0.5 mD and 10 mD cores, the effective oil extraction pressure for the scCO2 puff process is found to be 5~10 MPa, which is much higher than 0~2 MPa for the N2 puff process. The study's findings can help provide a better understanding of the oil extraction behaviors in the huff-n-puff process with different injection fluids as well as in different low permeability cores.
Development of a Special Classification of Information Assets in the Information Security Field
Authors:   Orenburg State University, Manzhosov Artem V. , Bolodurina Irina P. ,   Orenburg State University, Saburov Vadim S. ,   Orenburg State University, Dolgushev Nikita A. ,   Orenburg State University
Published: December 2022

The analysis of definitions of the concept of "information asset" was carried out, which showed the versatility of information assets in the information security field. A review of sources on the topic of research was performed, which determined that the topic of research is discussed and relevant to the Russian and international agendas. Classification of information assets in legal acts was compared, which made it possible to determine the recommended basic list of information assets. A special classification of information assets was developed, which systematizes classes of information assets by the criterion of possibility of information security risks impact on the information asset.