bluuebunny/crossref_metadata_2025 huggingface dataset:
Activity‐Based Profiling of Retaining β‐Glucosidases: A Comparative Study
Authors: Witte Martin D. , Walvoort Marthe T. C. , Li Kah‐Yee , Kallemeijn Wouter W. , Donker‐Koopman Wilma E. , Boot Rolf G. , Aerts Johannes M. F. G. , Codée Jeroen D. C. , van der Marel Gijsbert A. , Overkleeft Herman S.
Published: April 2011

Activity‐based protein profiling (ABPP) is a versatile strategy to report on enzyme activity in vitro, in situ, and in vivo. The development and use of ABPP tools and techniques has met with considerable success in monitoring physiological processes involving esterases and proteases. Activity‐based profiling of glycosidases, on the other hand, has proven more difficult, and to date no broad‐spectrum glycosidase activity‐based probes (ABPs) have been reported. In a comparative study, we investigated both 2‐deoxy‐2‐fluoroglycosides and cyclitol epoxides for their utility as a starting point towards retaining β‐glucosidase ABP. We also investigated the merits of direct labeling and two‐step bio‐orthogonal labeling in reporting on glucosidase activity under various conditions. Our results demonstrate that 1) in general cyclitol epoxides are the superior glucosidase ABPs, 2) that direct labeling is the more efficient approach but it hinges on the ability of the glucosidase to be accommodated in the active site of the reporter (BODIPY) entity, and 3) that two‐step bio‐orthogonal labeling can be achieved on isolated enzymes but translating this protocol to cell extracts requires more investigation.
Click Peptide Concept: O‐Acyl Isopeptide of Islet Amyloid Polypeptide as a Nonaggregative Precursor Molecule
Authors: Yoshiya Taku , Higa Ayano , Abe Naoko , Fukao Fukue , Kuruma Tomomi , Toda Yuki , Sohma Youhei , Kiso Yoshiaki
Published: April 2011

The O‐acyl isopeptide (1) of islet amyloid polypeptide (IAPP), which contains an ester moiety at both Ala8‐Thr9 and Ser19‐Ser20, was prepared by sequential segment condensation based on the O‐acyl isopeptide method. Isopeptide 1 possessed nonaggregative properties, retaining its random coil structure under the acidic conditions; this suggests that the insertion of the O‐acyl isopeptide structures in IAPP suppressed aggregation of the molecule. As a result of the rapid O‐to‐N acyl shift of 1 under neutral pH, in situ‐formed IAPP adopted a random‐coil structure at the start of the experiment, and then underwent conformational change to α‐helix/β‐sheet mixed structures as well as aggregation. The click peptide strategy with the nonaggregative precursor molecule 1 could be a useful experimental tool to identify the functions of IAPP, by overcoming the handling difficulties that arise from IAPP's intense and uncontrollable self‐assembling nature.
Arterial duct stenting in low‐weight newborns with duct‐dependent pulmonary circulation
Authors: Santoro Giuseppe , Gaio Gianpiero , Castaldi Biagio , Palladino Maria Teresa , Iacono Carola , Russo Maria Giovanna , Calabrò Raffaele
Published: April 2011

Objectives: To evaluate feasibility and results of arterial duct (AD) stenting in low‐weight newborns with congenital heart disease and duct‐dependent pulmonary circulation (CHD‐DPC). Background: AD stenting is nowadays considered a cost‐effective alternative to surgical shunt in CHD‐DPC. This option might be even more advisable in low‐weight neonates (<2.5 kg), who are at higher surgical risk and in whom stent redilation might adapt shunt magnitude to patient's growth. Methods: Between April 2003 and September 2010, 76 neonates with CHD‐DPC underwent AD stenting at our institution, as lower‐risk palliation with respect to surgical shunt. Procedural and follow‐up data of the 15 low‐weight newborns (2.0 ± 0.3 kg, median 2.2) (group I) were compared with the remaining normal‐weight newborns (3.5 ± 0.7 kg, median 3.2) (group II). Results: Feasibility, complication rate, and need for surgical shunt did not significantly differ between groups. Global X‐ray exposure was significantly higher in the low‐weight group (82 ± 108 vs. 30 ± 33 Gray/cm2, P < 0.002), which maybe due to a longer angiographic presenting work‐up. In‐hospital mortality rate was 14.3% (vs. 1.9% in the group II, P = NS), although none of the fatalities was procedure‐related. During follow‐up, five patients (35.7% vs. 15.7% in the group II, P = NS) underwent stent redilation before surgical repair. At control angiography, the Nakata and McGoon indexes had significantly increased (P < 0.05 for both comparisons), without any significant difference with the group II (162 ± 52% vs. 144 ± 158% and 40 ± 17% vs. 42 ± 38%, P = NS). Conclusions: AD stenting is also feasible and effective in low‐weight newborns with CHD‐DPC, supporting the spontaneous improvement process or promoting a significant pulmonary artery growth. © 2011 Wiley‐Liss, Inc.
Endovascular treatment of abdominal aortic aneurysms combined with bilateral common and internal iliac aneurysms
Authors: Sadeghi‐Azandaryani Mojtaba , Strube Hanna , Chappell Daniel , Treitl Marcus , Hinske Ludwig C. , Steckmeier Bernd , Heyn Jens
Published: April 2011

Introduction:

: Combined aneurysms of aortic and iliac arteries are rare with a prevalence of less than 0.1%. However, these combined aneurysms are associated with a high incidence of thrombosis, distal embolism, or rupture. Endovascular repair is a therapeutic option and includes embolization of the internal iliac artery in numerous cases. Embolization of the internal iliac artery may cause severe ischemia with hip and buttock complications in 2–5%. Therefore, preservation of internal iliac arteries is essential to reduce complications.

Patient and Method:

: We describe in detail an endovascular procedure for combined abdominal aortic (diameter of 8.6 cm) and bilateral common and internal iliac aneurysm (diameter of the left side: 6.4 cm; diameter of the right side: 4.3 cm) in a 44‐year‐old patient caused by media necrosis Erdheim‐Gsell. The blood flow of both internal arteries was preserved in this patient.

Result:

: Operation was done without any complications. Conversion to an open procedure was not necessary. During follow up (3, 6, and 12 months after operation) the patient did not develop any signs of severe hip and buttock complications. Furthermore, sonography and CT angiography revealed a good blood flow via the internal and external iliac arteries.

Conclusion:

: Endovascular repair of abdominal aortic aneurysms combined with bilateral common and internal iliac aneurysms offers a promising minimal invasive procedure. Most importantly, this technique is less invasive than open operations and reduces complications by preserving the pelvic perfusion. © 2011 Wiley Periodicals, Inc.
Comparison of pharmacokinetics of the limus‐eluting stents in Japanese patients
Authors: Otsuka Yoritaka , Saito Shigeru , Nakamura Masato , Shuto Hideo , Mitsudo Kazuaki
Published: April 2011

Objectives:

: The aim of this study was to compare the pharmacokinetics of the four limus‐eluting stents used in Japanese patients.

Background:

: There are presently no reports comparing human pharmacokinetics among drug‐eluting stents (DESs).

Methods:

: We retrospectively analyzed data from pharmacokinetic studies of patients implanted with an 18‐mm DES: Cypher stent (sirolimus, n = 10), Endeavor stent (zotarolimus, n = 7), Xience V stent (everolimus, n = 6), and Nobori stent (biolimus A9, n = 10), in multicenter trials of Japan. Total drug doses of the Cypher stent, Endeavor stent, Xience V stent, and Nobori stent were 150, 180, 88, and 293 μg, respectively. Drug concentrations were measured in serial whole blood samples after implantation and the pharmacokinetics were analyzed.

Results:

: Mean peak drug levels were 0.86 ng mL−1 for Cypher, 1.80 ng mL−1 for Endeavor, 0.50 ng mL−1 for Xience V, and 0.09 ng mL−1 for Nobori. After adjustment for the loaded dose, mean peak drug levels of the Cypher and Xience V stents were similar (0.0057 ng mL−1 μg−1 each) while the Endeavor (0.0100 ng mL−1 μg−1) was higher, and the Nobori (0.0003 ng mL−1 μg−1) was lower, compared with the Cypher and Xience V stents. The other pharmacokinetic parameters of four DESs differed according to characteristics of the coated drug. The systemic exposure of biolimus A9 was much lower than that of the other DESs studied.

Conclusions:

: In Japanese patients, systemic exposure was low, regardless of the type of limus drug eluted from the stents; but specific pharmacokinetic activities were varied according to the drug characteristics, concentration, and DES design. © 2011 Wiley Periodicals, Inc.
Percutaneous management of inferior epigastric artery injury after cardiac catheterization
Authors: Sanchez Carlos E. , Helmy Tarek
Published: April 2011

Inferior epigastric artery injury after cardiac catheterization and percutaneous coronary intervention is sporadically reported in the literature, yet it is a serious complication that can lead to life‐threatening retroperitoneal hemorrhage and poor clinical outcomes after percutaneous coronary intervention. We present two cases of inferior epigastric artery injury from inadvertent puncture during cardiac catheterization and a discussion in the management and prevention of this potentially fatal complication. © 2011 Wiley Periodicals, Inc.
Large calibre arterial access device closure for percutaneous aortic valve interventions: Use of the prostar system in 118 cases
Authors: Cockburn James , de Belder Adam , Brooks Michael , Hutchinson Nevil , Hill Andrew , Trivedi Uday , Hildick‐Smith David
Published: April 2011

Background:

: Percutaneous aortic valve treatments, balloon aortic valvuloplasty (BAV) and transcatheter aortic valve implantation (TAVI), are effective ways to treat patients with symptomatic aortic stenosis when open surgical repair is not feasible or considered too high risk. Large bore vascular access is required, and successful management of this arterial access is key to overall procedural success. We report outcomes and complications using the Prostar vascular closure device following BAV and TAVI.

Methods:

: During the period under consideration, 54 patients underwent BAV and 64 patients underwent TAVI (n = 118). Procedural data and outcomes were collected prospectively on a dedicated database.

Results:

: Patients were aged 80 ± 6.9 years (BAV) and 80.8 ± 6.1 years (TAVI) and 46.2% (BAV) and 46.8% (TAVI) were male, respectively. Primary success (hemostasis achieved immediately after deployment of the Prostar system on the table and persisting for a minimum of 24 hr in the absence of major or minor bleeding complications) was achieved in 94.4% (n = 54) of the patients undergoing BAV and 92.2% (n = 64) of the patients undergoing TAVI, respectively. The combined success rate was 93.3%. Major bleeding (see definitions section) was seen in 1.9% of cases in the BAV group and 4.7% of cases in the TAVI group. Minor bleeding (see definitions section) was seen in 3.7% of cases in the BAV group and 3.1% of cases in the TAVI group.

Conclusions:

: Use of the Prostar vascular closure system to achieve hemostasis following percutaneous aortic valve interventions is associated with a high primary success rate and acceptable level of bleeding complications. © 2011 Wiley Periodicals, Inc
Aspiration thrombectomy for acute foot and hand ischemia
Authors: Higashimori Akihiro , Kawarada Osami , Yokoi Yoshiaki
Published: April 2011

Acute thromboembolic occlusion of the arteries of the extremities is a potentially fatal vascular emergency that requires an early diagnosis and rapid restoration of blood flow. Selective thrombolysis or surgical treatment has been used, but such procedures are sometimes difficult because of the advanced clinical stage of the embolus and the high risk of thromboembolysis therapy. Herein, we describe the clinical utility of aspiration thrombectomy for acute foot and hand ischemia. © 2011 Wiley Periodicals, Inc.
Contemporary approaches to saphenous vein graft interventions: A survey of 275 interventional cardiologists
Authors: Mahmood Arif , Khair Tarif , Abdel‐Karim Abdul‐Rahman R. , Papayannis Aristotelis , Xu Hao , Banerjee Subhash , Brilakis Emmanouil S.
Published: April 2011

Background: We sought to examine contemporary practice patterns of saphenous vein graft (SVG) interventions. Methods: A link to a 10‐item online questionnaire was completed in June 2009 by 275 (7%) of 3,771 US interventional cardiologists surveyed. Results: Sixty‐five percent of the respondents use an embolic protection device (EPD) in >75% of SVG interventions. The main reason for not using an EPD was “anatomic difficulties” (55%), followed by device complexity (20%). Filter‐based EPDs were the most widely available, well known, and commonly used EPDs, whereas the Guardwire (Medtronic Vascular) was the least commonly used EPD. The main factors underlying EPD selection were lesion location (83%), familiarity with devices (72%), and SVG diameter (64%). Factors that could increase EPD use included availability of simpler to use devices (63%), and more studies demonstrating benefit from EPD use (37%). Compared with interventionalists who used EPDs in most cases (>75%), those who utilized EPDs less frequently were less likely to be familiar with each EPD and had less EPDs available for use. Many interventionalists (84%) administer intragraft vasodilators during SVG interventions, prefer drug‐eluting stents (63%) and administer >12 months antiplatelet therapy poststent implantation.Conclusions: During SVG interventions (1) “anatomic difficulties” are the most common reason for not utilizing an EPD; (2) filter‐based EPDs are most commonly used; (3) lesion location is the most important factor for EPD selection; (4) availability of simpler to use devices could increase EPD use; and (5) intragraft vasodilators, drug‐eluting stents and prolonged antiplatelet therapy are commonly utilized. © 2011 Wiley‐Liss, Inc.
Selective CO2 Adsorption by a Triazacyclononane‐Bridged Microporous Metal–Organic Framework
Authors: Ortiz Guillaume , Brandès Stéphane , Rousselin Yoann , Guilard Roger
Published: April 2011

Metal–organic frameworks constructed by self‐assembly of metal ions and organic linkers have recently been of great interest in the preparation of porous hybrid materials with a wide variety of functions. Despite much research in this area and the large choice of building blocks used to fine‐tune pore size and structure, it remains a challenge to synthesise frameworks composed of polyamines to tailor the porosity and adsorption properties for CO2. Herein, we describe a rigid and microporous three‐dimensional metal–organic framework with the formula [Zn2(L)(H2O)]Cl (L=1,4,7‐tris(4‐carboxybenzyl)‐1,4,7‐triazacyclononane) synthesised in a one‐pot solvothermal reaction between zinc ions and a flexible cyclic polyaminocarboxylate. We have demonstrated, for the first time, that a porous rigid framework can be obtained by starting from a flexible amine building block. Sorption measurements revealed that the material exhibited a high surface area (1350 m2 g−1) and was the best compromise between capacity and selectivity for CO2 over CO, CH4, N2 and O2; as such it is a promising new selective adsorbent for CO2 capture.
Heteroleptic Ruthenium Sensitizers That Contain an Ancillary Bipyridine Ligand Tethered with Hydrocarbon Chains for Efficient Dye‐Sensitized Solar Cells
Authors: Yen Yung‐Sheng , Chen Yung‐Chung , Hsu Ying‐Chan , Chou Hsien‐Hsin , Lin Jiann T. , Yin Da‐Jong
Published: April 2011

New heteroleptic ruthenium complexes have been synthesized and used as the sensitizers for dye‐sensitized solar cells (DSSCs). The ancillary bipyridine ligand contains rigid aromatic segments (fluorene‐, carbazole‐, or dithieno[3,2‐b:2′,3′‐d]pyrrole‐substituted bipyridine) tethered with a hydrophobic hexyl substituent. The conjugated aromatic segment results in significant bathochromic shift and hyperchromic effects in these complexes compared with Z907 (cis‐[RuLL′(NCS)2]; L=4,4′‐dicarboxylic acid‐2,2′‐bipyridine, L′=4,4′‐dinonyl‐2,2′‐ bipyridine). The long hydrocarbon chains help to suppress the dark current if appropriately disposed. DSSCs that use these complexes exhibit very impressive conversion efficiencies (5.94 to 6.91 %) that surpass that of Z907‐based (6.36 %) DSSCs and are comparable with that of N719‐based standard cells (7.13 %; N719=cis‐di(thiocyanato)bis(2,2′‐bipyridyl‐4,4′‐dicarboxylato)ruthenium(II) bis(tetrabutylammonium)) fabricated and measured under similar conditions (active area: 0.5×0.5 cm2; AM 1.5 sunlight).
ChemInform Abstract: Structural, Ferroelectric and Magnetic Properties of Bi0.85Sm0.15FeO3 Perovskite.
Authors: Khomchenko V. A. , Paixao J. A. , Costa B. F. O. , Karpinsky D. V. , Kholkin A. L. , Troyanchuk I. O. , Shvartsman V. V. , Borisov P. , Kleemann W.
Published: April 2011

The title compound is synthesized by solid state reaction of Bi2O3, Sm2O3, and Fe2O3 (850 °C for 6 h and 950 °C for 5 h).
ChemInform Abstract: Preparation and Characterization of PdFe Nanoleaves as Electrocatalysts for Oxygen Reduction Reaction.
Authors: Zhang Zhiyong , More Karren L. , Sun Kai , Wu Zili , Li Wenzhen
Published: April 2011

PdxFe (x = 1, 2, 5) nanoleaves are prepared from mixtures of Pd(acac)2, Fe(CO)5, and oleylamine (160 °C, 30 min).
ChemInform Abstract: Li4Cs3B7O14: Synthesis, Crystal Structure, and Optical Properties.
Authors: Yang Yun , Pan Shilie , Li Hongyi , Han Jian , Chen Zhaohui , Zhao Wenwu , Zhou Zhongxiang
Published: April 2011

The title compound, a new nonlinear optical material, is prepared by solid state reaction of a stoichiometric mixture of Li2CO3, Cs2CO3, and H3BO3 at 560 °C (48 h).
ChemInform Abstract: Uniform Hollow Lu2O3:Ln (Ln: Eu3+, Tb3+) Spheres: Facile Synthesis and Luminescent Properties.
Authors: Yang Piaoping , Gai Shili , Liu Yanchao , Wang Wenxin , Li Chunxia , Lin Jun
Published: April 2011

Carbon microspheres are hydrothermally obtained from aqueous solutions of glucose (autoclave, 170 °C, 9 h) and used as templates in the synthesis of uniform hollow Lu2O3:Ln (Ln: Eu3+, Tb3+) spheres by reaction of Lu(NO3)3 and Ln(NO3)3 in the presence of urea (H2O, 90 °C, 4 h; calcination in air, 800 °C, 2 h).
ChemInform Abstract: Sm2‐xDyxZr2O7 Pyrochlores: Probing Order—Disorder Dynamics and Multifunctionality.
Authors: Sayed Farheen N. , Grover V. , Bhattacharyya K. , Jain D. , Arya A. , Pillai C. G. S. , Tyagi A. K.
Published: April 2011

The title compounds (0.0 ≤ x ≤ 2.0) are synthesized by a gel combustion process from mixtures of Sm2O3, Dy2O3, ZrO(NO3)2·H2O, and glycine as a fuel (250 °C) followed by calcination at 700 °C in static air for 30 min.
ChemInform Abstract: Extension of the Clathrate Family: The Type X Clathrate Ge79P29S18Te6.
Authors: Kirsanova Maria A. , Olenev Andrei V. , Abakumov Artem M. , Bykov Mikhail A. , Shevelkov Andrei V.
Published: April 2011

Single crystals of the new title compound are synthesized from stoichiometric mixtures of the elements (silica ampules, 550 °C, 72 h).
ChemInform Abstract: Suprising Coordination for Plutonium in the First Plutonium(III) Borate.
Authors: Wang Shuao , Alekseev Evgeny V. , Depmeier Wulf , Albrecht‐Schmitt Thomas E.
Published: April 2011

Compound (II) crystallizes in the monoclinic space group Pn with Z = 1 (single crystal XRD).
ChemInform Abstract: Syntheses, Crystal and Electronic Structures, and Characterizations of Quaternary Antiferromagnetic Sulfides: Ba2MFeS5 (M: Sb, Bi).
Authors: Geng Lei , Cheng Wen‐Dan , Zhang Hao , Lin Chen‐Sheng , Zhang Wei‐Long , Li Ye‐Yu , He Zhang‐Zhen
Published: April 2011

Single crystals of the new title compounds are synthesized by solid state reactions of BaS, Sb or Bi, Fe, and S (silica tubes, 1123 K, 30 h).
ChemInform Abstract: Synthesis, Crystal Structure, and Physical Properties of BaAg2Cu[VO4]2: A New Member of the S=1/2 Triangular Lattice.
Authors: Amuneke Ngozi E. , Gheorghe Dana E. , Lorenz Bernd , Moeller Angela
Published: April 2011

Single crystals of the title compound are prepared by reaction of an equimolar mixture of CuO, V2O5, and Ba(OH)2·8H2O in a CsOH flux (silver source: Ag container 1.
ChemInform Abstract: Solid‐State Photoluminescence Sensitization of Tb3+ by Novel Au2Pt2 and Au2Pt4 Cyanide Clusters.
Authors: Ladner LeAnn , Ngo Tu , Crawford Carlos , Assefa Zerihun , Sykora Richard E.
Published: April 2011

The structures of the new heterotrimetallic metallocyanates (IV) (tetragonal, space group P42/nnm, Z = 4) and (V) (triclinic, P$\bar 1$, Z = 2) are determined by single crystal XRD.
ChemInform Abstract: Organocatalyzed Michael Addition Reaction by Novel (2R,3aS,7aS)‐Octahydroindole‐2‐carboxylic Acid, a New Fused Proline.
Authors: Roca‐Lopez David , Merino Pedro , Sayago Francisco J. , Cativiela Carlos , Herrera Raquel P.
Published: April 2011

The asymmetric Michael addition of acetone to nitroolefins in the presence of various proline related catalysts is investigated.
ChemInform Abstract: Regioselective Rhodium(II)‐Catalyzed Hydroaminations of Propargylguanidines.
Authors: Gainer Morgan J. , Bennett Nitasha R. , Takahashi Yu , Looper Ryan E.
Published: April 2011

Dimeric rhodium(II) octanoate catalyzes the 6‐endo‐dig selective hydroamination of propargylguanidines (I).
ChemInform Abstract: Rhodium‐Catalyzed Tandem Heterocyclization and Carbonylative [(3 + 2) + 1] Cyclization of Diyne‐enones.
Authors: Zhao Wanxiang , Zhang Junliang
Published: April 2011

It allows a simple and highly efficient access to polycyclic furans and fused phenols like (IV), (VII), and (X).
ChemInform Abstract: Ag(I)‐Catalyzed Regioselective Ring‐Opening of N‐Tosylaziridine and N‐Tosylazetidine with S‐, O‐, and N‐Nucleophiles and Tethered Dinucleophiles.
Authors: Bera Milan , Pratihar Sanjay , Roy Sujit
Published: April 2011

The title reaction allows access to a number of 1,2‐ and 1,3‐amino ethers, amino thioethers, and diamines.
ChemInform Abstract: Flexible Gold‐Catalyzed Regioselective Oxidative Difunctionalization of Unactivated Alkenes.
Authors: de Haro Teresa , Nevado Cristina
Published: April 2011

The gold‐catalyzed alkene aminooxygenation and aminoamidation reactions are highly regioselective in several cases, thus complementing 5‐exo palladium‐catalyzed processes.
ChemInform Abstract: An Efficient and Regioselective Monobromination of Electron‐Rich Aromatic Compounds Using Catalytic Hypervalent Iodine(III) Reagent.
Authors: Zhou Zhongshi , He Xuehan
Published: April 2011

A hypervalent iodine(III) reagent is generated in situ from iodobenzene, MCPBA, and TosOH.
ChemInform Abstract: Hydrogen Peroxide or Peracetic Acid Mediated Self‐Titrating α‐Halogenation of 1,3‐Dicarbonyl Compounds.
Authors: Akula Ramulu , Galligan Marc J. , Ibrahim Hasim
Published: April 2011

Generally, the reactions with peracid give consistently cleaner products than those carried out with H2O2.
ChemInform Abstract: Halogenation of 1,1‐Diaryl Alkenes.
Authors: Chang Meng‐Yang , Lee Ming‐Fang , Lin Chung‐Han , Lee Nein‐Chia
Published: April 2011

1,1‐Diarylalkenes react with Selectfluor or N‐halosuccinimides under mild and base‐ free conditions.
ChemInform Abstract: Preparation of Trifluoroethyl‐ and Phenyl‐Protected Sulfates Using Sulfuryl Imidazolium Salts.
Authors: Desoky Ahmed Y. , Hendel Jennifer , Ingram Laura , Taylor Scott Douglas
Published: April 2011

For the O‐protection in carbohydrates or steroids, sulfurylimidazolium salts (II) having a methyl group at the 2‐position of the imidazole ring are in general superior sulfating agents in comparison to analogues lacking the methyl group.
ChemInform Abstract: Application of the Copper‐Catalyzed N‐Arylation of Amidines in the Synthesis of Analogues of the Chemical Tool, Blebbistatin.
Authors: Lawson Christopher P. A. T. , Slawin Alexandra M. Z. , Westwood Nicholas J.
Published: April 2011

A protocol for the arylation of benzamidine (I) is elaborated.
ChemInform Abstract: Cross‐Coupling of Mesylated Phenol Derivatives with Potassium Ammonio‐ and Amidomethyltrifluoroborates.
Authors: Molander Gary A. , Beaumard Floriane
Published: April 2011

It provides a general and efficient method to prepare aminomethylated and amidomethylated arenes.
ChemInform Abstract: Nucleophilic α‐Arylation and α‐Alkylation of Ketones by Polarity Inversion of N‐Alkoxyenamines: Entry to the Umpolung Reaction at the α‐Carbon Position of Carbonyl Compounds.
Authors: Miyoshi Tetsuya , Miyakawa Takayuki , Ueda Masafumi , Miyata Okiko
Published: April 2011

The efficient and transition metal free umpolung reaction by polarity inversion at the β‐position of N‐alkoxyenamines is characterized by mild conditions and simple transformation of ketones such as (I) into α‐substituted ketones (IV) without isolation of the intermediate enamine derivatives (II).
ChemInform Abstract: Chiral Linear Polymers Bonded Alternatively with Salen and 1,4‐Dialkoxybenzene: Synthesis and Application for Ti‐Catalyzed Asymmetric TMSCN Addition to Aldehydes.
Authors: Sakthivel Sekarpandi , Punniyamurthy Tharmalingam
Published: April 2011

A polymeric titanium/salen catalyst (ca. 15 repeating units) promotes the asymmetric addition of TmsCN to aldehydes with enantioselectivities comparable to those of the corresponding monomeric catalyst.
ChemInform Abstract: Recoverable Cinchona Ammonium Salts as Organocatalysts in the Enantioselective Michael Addition of β‐Keto Esters.
Authors: Tari Silvia , Chinchilla Rafael , Najera Carmen
Published: April 2011

Dimeric Cinchona‐alkaloid derived ammonium salts are shown to catalyze the title reaction with up to 94% e.e.
ChemInform Abstract: Palladium‐Catalyzed Selective Acyloxylation Using Sodium Perborate as Oxidant.
Authors: Pilarski Lukasz T. , Janson Paer G. , Szabo Kalman J.
Published: April 2011

A new, inexpensive, highly regio‐ and stereoselective method to prepare diverse allylic esters is reported.
ChemInform Abstract: Unusual β,β′‐Coupling and β‐Alkylation of Methyl 2,3,3‐Trifluoropropenoate by Lithium Diorganocuprates.
Authors: Hajduch Jan , Paleta Oldrich
Published: April 2011

Title compound (I) reacts with lithium diorganocuprates (II) depending on the organyl component in the cuprates in two ways, by fluorine substitution with alkyl or aryl or by β,β′‐C,C‐coupling.
ChemInform Abstract: Sulfonamidoquinoline/Palladium(II)‐Dimer Complex as a Catalyst Precursor for Palladium‐Catalyzed γ‐Selective and Stereospecific Allyl—Aryl Coupling Reaction Between Allylic Acetates and Arylboronic Acids.
Authors: Makida Yusuke , Ohmiya Hirohisa , Sawamura Masaya
Published: April 2011

A new complex PQD is used as an efficient catalyst for the γ‐selective coupling reaction between allylic acetates and arylboronic acids.
ChemInform Abstract: Coupling of N‐Tosylhydrazones with Terminal Alkynes Catalyzed by Copper(I): Synthesis of Trisubstituted Allenes.
Authors: Xiao Qing , Xia Ying , Li Huan , Zhang Yan , Wang Jianbo
Published: April 2011

A wide range of trisubstituted allenes is directly synthesized by reaction of N‐tosylhydrazones with terminal alkynes under mild conditions with low catalyst loading.
ChemInform Abstract: Intermolecular Morita—Baylis—Hillman Reactions Using Dicobalthexacarbonyl Complexed Acetylenic Acetals.
Authors: Krafft Marie E. , Campbell Mark J. , Kerrigan Sean , Cran John W.
Published: April 2011

Treatment of Co‐complexes (I) with BF3·OEt2 generates stabilized cationic intermediates which react with activated alkenes (II) to provide coupling products (III) after decomplexation.
ChemInform Abstract: First Synthesis of Bromo and Chloro Derivatives of Baylis—Hillman Adducts Derived from Nitroolefins: Application Towards the Synthesis of a Dendrimer Core.
Authors: Bakthadoss Manickam , Sivakumar Nagappan , Devaraj Anthonisamy
Published: April 2011

Treatment of nitrolefins with aqueous formaldehyde results in formation of nitropropenols which undergo SN2 reactions with HBr and FeCl3 to afford the title compounds.
ChemInform Abstract: Asymmetric Hydrogenation of N‐Alkyl Ketimines with Phosphine‐Free, Chiral, Cationic Ru‐MsDPEN Catalysts.
Authors: Chen Fei , Wang Tianli , He Yanmei , Ding Ziyuan , Li Zhiwei , Xu Lijin , Fan Qing‐Hua
Published: April 2011

A wide range of N‐alkyl imines is efficiently hydrogenated under mild conditions using a chiral Ru catalyst in the presence of Boc2O to give the corresponding N‐Boc‐protected amines in excellent enantioselectivity (up to 98% e.e.).
ChemInform Abstract: Synthesis, Antimicrobial Activity and Structure—Activity Relationship Study of N,N‐Dibenzyl‐cyclohexane‐1,2‐diamine Derivatives.
Authors: Sharma Mukul , Joshi Penny , Kumar Nitin , Joshi Seema , Rohilla Rajesh K. , Roy Nilanjan , Rawat Diwan S.
Published: April 2011

Synthesis and antimicrobial activity of a series of structurally diverse diamines (44 examples) are reported.
ChemInform Abstract: Guanidinium‐Tagged Organocatalysts for Direct Aldol Reactions.
Authors: Shah Jabbar , Liebscher Juergen
Published: April 2011

Hexasubstituted guanidinium moieties are used as ionic liquid tags for organocatalysts [cf.
ChemInform Abstract: Pd(II)‐Catalyzed Decarboxylative Allylation and Heck‐Coupling of Arene Carboxylates with Allylic Halides and Esters.
Authors: Wang Jiantao , Cui Zili , Zhang Yuexia , Li Huajie , Wu Long‐Min , Liu Zhongquan
Published: April 2011

This alternative method provides access to allylated arenes (III) and aryl‐substituted allylic esters (VI)/(VII) via catalytic decarboxylative C—C bond formation using aromatic carboxylic acids (I) and (IV) and allylic halides (II) and esters (V), respectively.
ChemInform Abstract: Elemental Iodine or Diphenyl Diselenide in the [Bis(trifluoroacetoxy)iodo]benzene‐Mediated Conversion of Alkynes into 1,2‐Diketones.
Authors: Tingoli Marco , Mazzella Mauro , Panunzi Barbara , Tuzi Angela
Published: April 2011

The transformation of alkynes (I) into α‐diketones (II) proceeds smoothly in the system PIFA—diphenyl diselenide.
ChemInform Abstract: Copper‐Catalyzed Aerobic Oxidative Synthesis of Aromatic Carboxylic Acids.
Authors: Yang Daoshan , Yang Haijun , Fu Hua
Published: April 2011

An efficient and practical method for the synthesis of aromatic carboxylic acids (21 examples) from corresponding aryl halides is developed using sequential Ullmann‐type coupling with malononitrile, aerobic oxidation and hydrolysis.
ChemInform Abstract: Asymmetric Synthesis of α‐Aryl Amino Acids: Aryne‐Mediated Diastereoselective Arylation.
Authors: Jones Elizabeth P. , Jones Peter , Barrett Anthony G. M.
Published: April 2011

Coupling of the pyrazine (I) with arynes, generated in situ, followed by pyrazine ring cleavage allows access to various enantiomerically enriched α‐arylglycines.
ChemInform Abstract: Synthesis of Amides via Palladium‐Catalyzed Amidation of Aryl Halides.
Authors: Jiang Huanfeng , Liu Bifu , Li Yibiao , Wang Azhong , Huang Huawen
Published: April 2011

A new, simple, and efficient approach to aromatic amides is reported.
ChemInform Abstract: A Mild and Efficient Palladium‐Catalyzed Cyanation of Aryl Chlorides with K4[Fe(CN)6].
Authors: Yeung Pui Yee , So Chau Ming , Lau Chak Po , Kwong Fuk Yee
Published: April 2011

The mild conditions allow the presence of a wide scope of sensitive functional groups.
ChemInform Abstract: Silver Nitrate Catalyzed Oxidation of Sulfides.
Authors: Das Rima , Chakraborty Debashis
Published: April 2011

A simple and efficient method is developed for sulfides and disulfides.
ChemInform Abstract: Ruthenium‐Catalyzed Synthesis of 1,5‐Dichlorides by Sequential Intermolecular Kharasch Reactions.
Authors: Thommes Katrin , Fernandez‐Zumel Mariano A. , Buron Charlotte , Godinat Aurelien , Scopelliti Rosario , Severin Kay
Published: April 2011

Ruthenium‐catalyzed reaction of styrene derivatives (II) with α,α‐dichloro‐malononitrile, ‐malonate or ‐acetonitrile (I) proceeds via a double Kharasch pathway to give symmetrical or unsymmetrical 1,5‐diaryl‐1,5‐dichlorides in good yields.
ChemInform Abstract: Cobalt‐Catalyzed Addition of Styrylboronic Acids to 2‐Vinylpyridine Derivatives.
Authors: Kobayashi Tsuneyuki , Yorimitsu Hideki , Oshima Koichiro
Published: April 2011

Cobalt‐catalyzed addition of vinylpyridine derivatives to styrylboronic acids results in formation of butenyl heteroarenes.
ChemInform Abstract: Consecutive One‐Pot Sonogashira—Glaser Coupling Sequence — Direct Preparation of Symmetrical Diynes by Sequential Pd/Cu Catalysis.
Authors: Merkul Eugen , Urselmann Dominik , Mueller Thomas J. J.
Published: April 2011

Sonogashira cross coupling of (het)aryl iodides (I) and (IV) with trimethylsilylacetylene (II) is successfully combined with Glaser coupling using air as oxidant to give symmetrical diaryldiacetylenes (III) and (V), resp., in a two‐step one‐pot sequence.
ChemInform Abstract: Chemoselective Phosphine‐Catalyzed Cascade Annulations Between Two Different Activated Alkenes: Highly Diastereoselective Syntheses of Polysubstituted Cyclohexanes and Cyclopentenes.
Authors: Cai Lingchao , Zhang Bo , Wu Guiping , Song Haibin , He Zhengjie
Published: April 2011

Cascade [2 + 2 + 2] and [2 + 2 + 1] annulations between 2 molecules of 2‐arylidene cyanoacetates or malononitriles and 1 molecule of α,β‐unsaturated ketones are presented.
ChemInform Abstract: A Biomimetic Iron Catalyst for the Epoxidation of Olefins with Molecular Oxygen at Room Temperature.
Authors: Schroeder Kristin , Join Benoit , Amali Arlin Jose , Junge Kathrin , Ribas Xavi , Costas Miquel , Beller Matthias
Published: April 2011

A novel method is developed using air as the oxidant.
ChemInform Abstract: Organocatalytic Asymmetric Direct Vinylogous Aldol Reactions of γ‐Crotonolactone with Aromatic Aldehydes.
Authors: Pansare Sunil V. , Paul Eldho K.
Published: April 2011

The reaction is catalyzed by bifunctional organocatalysts (I) and provides diastereomerically and enantiomerically enriched 5‐substituted 2(5H)‐furanones (IV).
ChemInform Abstract: Site‐Selective Suzuki—Miyaura Cross‐Coupling Reactions of 2,3,4,5‐Tetrabromofuran.
Authors: Hussain Munawar , Khera Rasheed Ahmad , Hung Nguyen Thai , Langer Peter
Published: April 2011

Procedures are developed for a selective preparation of mono‐, bis‐ and symmetrical and unsymmetrical tetra‐arylated furan derivatives.
ChemInform Abstract: Efficient Synthesis of Functionalized Butenolides Mediated by Vinyltriphenylphosphonium Salts in Aqueous Media.
Authors: Khalilzadeh Mohammad A. , Hasannia Adel , Baradarani Mohammad M. , Hossaini Zinatossadat
Published: April 2011

The reaction of esters (II) with triphenylphosphine results in formation vinyltriphenylphosphonium salts which react with carbonyl compounds (I) or (IV) to produce highly functionalized butenolides.
ChemInform Abstract: Diastereoselective Hydroformylation of 2,5‐Cyclohexadienyl‐1‐carbinols with Catalytic Amounts of a Reversibly Bound Directing Group.
Authors: Usui Ippei , Nomura Kenichi , Breit Bernhard
Published: April 2011

The bicyclic lactones are interesting building blocks with an alkene function for further conversions.
ChemInform Abstract: Ruthenium‐Catalyzed Oxidative Vinylation of Heteroarene Carboxylic Acids with Alkenes via Regioselective C—H Bond Cleavage.
Authors: Ueyama Takumi , Mochida Satoshi , Fukutani Tatsuya , Hirano Koji , Satoh Tetsuya , Miura Masahiro
Published: April 2011

The procedure provides a new shortcut for vinylindole carboxylic acid derivatives [cf.(XIc)], which exhibit neuroprotective activities.
ChemInform Abstract: Synthesis of Chiral Cyclic Nitrones by Asymmetric Addition of β‐Ketosulfones to Nitroalkenes Followed by Reductive Cyclization.
Authors: Garcia Mancheno Olga , Tangen Pia , Rohlmann Renate , Froehlich Roland , Aleman Jose
Published: April 2011

The addition step is catalyzed by thiourea cinchona alkaloids like (I) to give the sulfone addition products as diastereomeric mixtures.
ChemInform Abstract: Enantioselective Friedel—Crafts Alkylation of Indole Derivatives Catalyzed by New Yb(OTf)3‐Pyridylalkylamine Complexes as Chiral Lewis Acids.
Authors: Grach Guillaume , Dinut Aurelia , Marque Sylvain , Marrot Jerome , Gil Richard , Prim Damien
Published: April 2011

Complex (I) is effective in the reaction of indole derivatives with trifluoropyruvate.
ChemInform Abstract: N‐Heterocyclic Carbene Catalyzed Domino Reactions of Formylcyclopropane 1,1‐Diesters: Construction of a 6‐5‐5 Tricyclic Pyrrolo[1,2‐a]indole.
Authors: Li Linxia , Du Ding , Ren Jun , Wang Zhongwen
Published: April 2011

An N‐heterocyclic carbene catalyzed domino ring‐opening/redox amidation/Knoevenagel condensation of indolecarbaldehydes and formylcyclopropanes is reported.
ChemInform Abstract: Synthesis of Dihydropyrano[3,2‐e]indoles as Rotationally Restricted Phenolic Analogues of 5‐Hydroxyindole—Thermal Claisen Approach versus Gold Catalysis.
Authors: Karageorge George N. , Macor John E.
Published: April 2011

The use on a gold catalyst facilitates the Claisen rearrangement/cyclization of propargyloxyindoles (I) allowing to reduce the reaction temperature from 156°C to 101°C with better yields of the condensed heterocycles (II).
ChemInform Abstract: Synthesis of Difluoroaryldioxoles Using BrF3.
Authors: Hagooly Youlia , Welch Michael J. , Rozen Shlomo
Published: April 2011

Treatment of catechols with thiophosgene provide the corresponding thiodioxoles which upon treatment with bromine trifluoride produce potentially biologically important difluoroaryldioxoles in good to very good yields.
ChemInform Abstract: Synthesis of 4(5)‐Phenacyl‐imidazoles from Isoxazole Side‐Chain Rearrangements.
Authors: Martorana Annamaria , Piccionello Antonio Palumbo , Buscemi Silvestre , Giorgi Gianluca , Pace Andrea
Published: April 2011

The reaction must be carried out under nitrogen atmosphere in deoxygenated solvent to prevent the oxidation of the imidazole products.
ChemInform Abstract: VO(acac)2‐Catalyzed Condensation of o‐Phenylenediamine with Aromatic Carboxylic Acids/Aldehydes under Microwave Radiation Affording Benzimidazoles.
Authors: Dey Madhudeepa , Deb Krishnajyoti , Dhar Siddhartha Sankar
Published: April 2011

Advantages of the method are high conversion, short reaction time and solvent‐free conditions.
ChemInform Abstract: Direct Arylation of Benzothiazoles and Benzoxazoles with Aryl Boronic Acids.
Authors: Ranjit Sadananda , Liu Xiaogang
Published: April 2011

Direct arylation of benzothiazole (IV) and benzoxazole (I) with a wide range of arylboronic acids is smoothly achieved in the presence of a Pd—Cu cocatalyst under aerobic conditions.
ChemInform Abstract: Copper(I) 1,2,3‐Triazol‐5‐ylidene Complexes as Efficient Catalysts for Click Reactions of Azides with Alkynes.
Authors: Nakamura Tatsuhito , Terashima Takahiro , Ogata Kenichi , Fukuzawa Shin‐ichi
Published: April 2011

Starting from triazoles, various copper‐aNHC complexes are prepared.
ChemInform Abstract: A New Palladium(II)‐Catalyzed [3,3] Aza‐Claisen Rearrangement of 3‐Allyloxy‐5‐aryl‐1,2,4‐oxadiazoles.
Authors: Fontana Gianfranco , Piccionello Antonio Palumbo
Published: April 2011

Substituted derivatives such as (Ib,c) react with very high degree of stereochemistry explained by a cationic palladacycle intermediate similar to the one postulated for the Cope‐rearrangement of 1,5‐dienes.
ChemInform Abstract: Synthesis, Antihypertensive Activity, and 3D‐QSAR Studies of Some New p‐Hydroxybenzohydrazide Derivatives.
Authors: Bhole Ritesh P. , Bhusari Kishore P.
Published: April 2011

A variety of new thiadiazole (V) and thiazole derivatives (IX) are synthesized starting from p‐hydroxybenzohydrazide (I).
ChemInform Abstract: Three‐Component Strategy Toward 5‐Membered Heterocycles from Isocyanide Dibromides.
Authors: El Kaim Laurent , Grimaud Laurence , Patil Pravin
Published: April 2011

A new and straightforward method to prepare tetrazoles and triazoles is reported.
ChemInform Abstract: Intramolecular Hydroalkoxylation in Broensted Acidic Ionic Liquids and Its Application to the Synthesis (.+‐.)‐Centrolobine (XXIb).
Authors: Jeong Yunkyung , Kim Do‐Young , Choi Yunsil , Ryu Jae‐Sang
Published: April 2011

The novel ionic liquids (I)—(III) are similarly effective in initial studies, but (Ia) and (II) are more effective in large‐scale reactions.
ChemInform Abstract: Gold(I)‐Catalyzed Access to Tetrahydropyran‐4‐ones from 4‐(Alkoxyalkyl)oxy‐1‐butynes: Formal Catalytic Petasis—Ferrier Rearrangement.
Authors: Bae Hyo Jin , Jeong Wook , Lee Ji Hyung , Rhee Young Ho
Published: April 2011

Substituted tetrahydropyranones are synthesized by the new method including a gold(I)‐catalyzed cycloisomerization which represents a catalytic alternative of the Petasis—Ferrier rearrangement.
ChemInform Abstract: Highly Enantioselective Conjugate Addition of Cyclic Diketones to β,γ‐Unsaturated α‐Ketoesters Catalyzed by an N,N′‐Dioxide—Cu(OTf)2 Complex.
Authors: Dong Zhenhua , Feng Juhua , Fu Xuan , Liu Xiaohua , Lin Lili , Feng Xiaoming
Published: April 2011

Title reaction provides access towards hexahydrobenzopyrans in high yields and excellent enantioselectivities (up to 99% e.e.).
ChemInform Abstract: In vitro Antiproliferative Activity of Benzopyranone Derivatives in Comparison with Standard Chemotherapeutic Drugs.
Authors: Musa Musiliyu A. , Cooperwood John S. , Khan M. Omar F. , Rahman Taufiq
Published: April 2011

In vitro results indicate that compounds (Ia)‐(Id) are more potent than tamoxifen against some human breast cancer cell lines.
ChemInform Abstract: Highly Efficient and Green Synthesis of 14‐Aryl(alkyl)‐14H‐dibenzo[a,j]xanthene and 1,8‐Dioxooctahydroxanthene Derivatives Catalyzed by Reusable Zirconyl Triflate [ZrO(OTf)2] under Solvent‐Free Conditions.
Authors: Mohammadpoor‐Baltork Iraj , Moghadam Majid , Mirkhani Valiollah , Tangestaninejad Shahram , Tavakoli Hamid Reza
Published: April 2011

The method for the synthesis of xanthene derivatives is advantageous with regard to a very short reaction time, high yield, and operational simplicity.
ChemInform Abstract: Synthesis of 14‐Aryl or Alkyl‐14H‐dibenzo[a,j]xanthenes Promoted by Mg(HSO4)2.
Authors: Mirjalili Bi Bi Fatemeh , Bamoniri Abdolhamid , Akbari Ali
Published: April 2011

The Mg(HSO4)2‐catalyzed condensation of 2‐naphthol with aldehydes can be carried out under neat conditions or in methylene chloride using ultrasound irradiation to give the title compounds in excellent yields.
ChemInform Abstract: Synthesis of Diisothiocyanato‐Functionalized 2,2′‐Bipyridines.
Authors: Kremer Christopher , Luetzen Arne
Published: April 2011

Diaminobipyridines such as (I) and (IV) are prepared by known three‐step sequence and converted into the corresponding diisothiocyanato derivatives upon treatment with thiophosgene.
ChemInform Abstract: 2‐Substituted‐2,3‐dihydro‐1H‐quinolin‐4‐ones via Acid‐Catalyzed Tandem Rupe Rearrangement—Donnelly—Farrell Ring Closure of 2‐(3′‐Hydroxypropynyl)anilines.
Authors: Pisaneschi Federica , Sejberg Jimmy J. P. , Blain Cecile , Ng Wang Hei , Aboagye Eric O. , Spivey Alan C.
Published: April 2011

ortho‐Amino substituted internal arylalkynes of type (III) are prepared by Sonogashira coupling.
ChemInform Abstract: Scandium(III) Zeolites as New Heterogeneous Catalysts: [4 + 2]Cyclocondensation of in situ Generated Aryl Imines with Alkenes.
Authors: Olmos Andrea , Sommer Jean , Pale Patrick
Published: April 2011

A ligand‐free catalyst is used for the cyclocondensation of amines and aldehydes with alkenes via in situ formation of imines.
ChemInform Abstract: Preparation of Benzolactams by Pd(II)‐Catalyzed Carbonylation of N‐Unprotected Arylethylamines.
Authors: Lopez Blanca , Rodriguez Aleix , Santos David , Albert Joan , Ariza Xavier , Garcia Jordi , Granell Jaume
Published: April 2011

An unprecedented NH2‐directed Pd(II)‐catalytic carbonylation of quaternary aromatic α‐amino esters produces 6‐membered benzolactams.
ChemInform Abstract: Iodine‐Catalyzed Formation of Aza‐Dienes: A Novel Synthesis of Angularly Fused Hexahydropyrano‐ and Furo[3,2‐c]quinoline Derivatives.
Authors: Reddy B. V. Subba , Grewal Harish
Published: April 2011

The reaction provides an efficient access to quinoline derivatives of potential biological relevance.
ChemInform Abstract: N,N′‐Dichlorobis(2,4,6‐trichlorophenyl)urea (CC‐2) as a New Reagent for the Synthesis of Pyrimidone and Pyrimidine Derivatives via Biginelli Reaction.
Authors: Rao G. B. Dharma , Acharya B. N. , Verma S. K. , Kaushik M. P.
Published: April 2011

The diarylurea is found to be an efficient reagent for the three‐component coupling of β‐ketoesters, aldehydes, and urea or thiourea to give pyrimidine derivatives (IV).
ChemInform Abstract: Silica‐Bonded N‐Propylsulfamic Acid as a Recyclable Catalyst for the Synthesis of 2,3‐Dihydroquinazolin‐4(1H)‐ones.
Authors: Niknam Khodabakhsh , Jafarpour Nasrolah , Niknam Ebrahim
Published: April 2011

The catalyst is successfully applied to the three‐component condensation reaction.
ChemInform Abstract: Two‐Step Synthesis of 1,3‐Disubstituted 3,4‐dihydro‐4‐thioxoquinazolin‐2(1H)‐ones from 1‐Bromo‐2‐fluorobenzenes.
Authors: Kobayashi Kazuhiro , Komatsu Toshihide , Yokoi Yuki , Konishi Hisatoshi
Published: April 2011

Benzothioamides (III) undergo addition—substitution with phenyl isocyanate (IV) to give the desired thioxoquinazolinones (Va)‐(Vc) in good yields.
ChemInform Abstract: Probing the Stereoselectivity of P‐Glycoprotein—Synthesis, Biological Activity and Ligand Docking Studies of a Set of Enantiopure Benzopyrano[3,4‐b][1,4]oxazines.
Authors: Jabeen Ishrat , Wetwitayaklung Penpun , Klepsch Freya , Parveen Zehida , Chiba Peter , Ecker Gerhard F.
Published: April 2011

Some of the title benzopyranooxazines and their precursors (I)/(II), e.g. (Ib), (Ic), (IIb), (IIc), and (IIIc) demonstrate significant P‐glycoprotein inhibitory activity.
ChemInform Abstract: Gold‐Catalyzed Tandem Intramolecular Heterocyclization/Petasis—Ferrier Rearrangement of 2‐(Prop‐2‐ynyloxy)benzaldehydes as an Expedient Route to Benzo[b]oxepin‐3(2H)‐ones.
Authors: Sze Ella Min Ling , Rao Weidong , Koh Ming Joo , Chan Philip Wai Hong
Published: April 2011

Uniquely, ring formation only proceeds efficiently in the presence of a gold catalyst.
ChemInform Abstract: HF‐Free, Direct Synthesis of Tetrabutylammonium Trifluoroborates.
Authors: Prakash G. K. Surya , Pertusati Fabrizio , Olah George A.
Published: April 2011

The synthesis of the target compounds from boronic acids and bifluoride (II) is advantageous with regards to safety and tolerability towards substrate functionality.
ChemInform Abstract: A General Synthetic Method for 1,1′‐Bis(diacetylene‐group)‐Connected Ferrocene and π‐Electronic System.
Authors: Yoshino Junro , Shimizu Rumi , Hayashi Naoto , Higuchi Hiroyuki
Published: April 2011

Under modified Eglinton oxidative coupling conditions, it is possible to generate 1,1′‐diethynylferrocene in situ from a trimethylsilyl‐protected precursor (I) and to react it with other terminal alkenes (III).
ChemInform Abstract: Neojaponicone A, a Bioactive Sesquiterpene Lactone Dimer with an Unprecedented Carbon Skeleton from Inula japonica.
Authors: Qin Jiang Jiang , Wang Li Yan , Zhu Jia Xian , Jin Hui Zi , Fu Jian Jun , Liu Xiao Feng , Li Hong Lin , Zhang Wei Dong
Published: April 2011

Compound (I) has an unprecedented carbon skeleton with an unusual valerolacton system formed between a guaianolide and an eudesmane.
ChemInform Abstract: A Powerful Synergistic Effect for Highly Efficient Diastereo‐ and Enantioselective Phase‐Transfer Catalyzed Conjugate Additions.
Authors: Hua Ming‐Qing , Wang Lian , Cui Han‐Feng , Nie Jing , Zhang Xiao‐Ling , Ma Jun‐An
Published: April 2011

A novel dinuclear N‐spiroammonium salt is prepared and successfully used as chiral catalyst in the conjugate addition of ester (II) to enones (I).
ChemInform Abstract: Highly Regio‐ and Stereoselective One‐Pot Synthesis of Carbohydrate‐Based Butyrolactones.
Authors: Yousuf Syed Khalid , Mukherjee Debaraj , L Malikharjunrao , Taneja Subhash C.
Published: April 2011

The method has the potential to generate libraries for biological screening.
ChemInform Abstract: CeCl3·7H2O: A Versatile and Efficient Reagent for the Synthesis of C‐Pyrrolyl Glycosides.
Authors: Reddy Basi V. Subba , Jain Ruchi , Bhargavi Kudikyala , Swain Manisha , Yadav Jhillu S.
Published: April 2011

A simple procedure allows the synthesis of pharmacologically important title compounds (IV) and (VI) via coupling of D‐glucosamine with 1,3‐diketones and β‐keto esters followed by acetylation.
ChemInform Abstract: Synthesis and Biological Evaluation of New 4β‐Anilino‐4′‐O‐demethyl‐4‐desoxypodophyllotoxin Derivatives as Potential Antitumor Agents.
Authors: Wang Li , Yang Fenyan , Yang Xiaochun , Guan Xianghong , Hu Chunqi , Liu Tao , He Qiaojun , Yang Bo , Hu Yongzhou
Published: April 2011

The title podophyllotoxin analogues are evaluated for their cytotoxicities against four human cancer cell lines including KB, KB/VCR, A549, and 95D.