bluuebunny/crossref_metadata_2025 huggingface dataset:
International Multidisciplinary Consensus on the Definition and Clinical Approach for Monogenic Inflammatory Immune Dysregulation Disorders
Authors: Alkwai Hend M , Almaghlouth Ibrahim A , Mendonça Leonardo Oliveira , Elkhalifa Shuayb , Abolhassani Hassan , Aljumaah Suliman , Al-Mousa Hamoud , Alosaimi Mohammed F , AlSaleem Alhanouf , Avcin Tadej , Chan Winnie KY , Espada Graciela , Frémond Marie-Louise , Gül Ahmet , Hadef Djohra , Movahedi Nasim , Wittkowski Helmut , Al-Mayouf Sulaiman M
Published: February 2025

Objective
To achieve consensus on the definition and clinical approach of Monogenic Inflammatory Immune Dysregulation Disorders (MIIDDs), a collective term for rare conditions marked by inflammation, immune dysregulation, and infection susceptibility.
Methods
A multi-step, evidence-based, multidisciplinary consensus process was employed, consisting of: 1) a systematic literature review across four electronic databases (Cochrane Library, Web of Science, Scopus, and MEDLINE via PubMed), updated through December 31, 2024; 2) a pre-Delphi electronic survey completed by 95 international adult and pediatric immunologists and rheumatologists; and 3) a modified online Delphi process with an international multidisciplinary expert panel, where statements were iteratively analyzed and refined until achieving consensus (≥ 80% agreement among panelists).
Results
Fifteen experts from 12 countries participated in two rounds of the Delphi process, resulting in the development of eight overarching principles and 10 consensus statements. These were categorized into five domains: 1) definitions and conceptual framework, 2) diagnostic and monitoring considerations, 3) treatment and therapeutic strategies, 4) multidisciplinary and collaborative care, and 5) patient education and support.
Conclusion
This consensus defines MIIDDs and provides a structured clinical framework to streamline research efforts and improve patient outcomes.
Antioxidants ameliorates glucose/glucose oxidase-induced myocardial damage through mitochondrial and MAPK Pathway
Authors: Kumar Santosh , Agrawal Prachi , Mendhey Prachi , Dhatwalia Sunil Kumar , Sitasawad Sandhya L.
Published: February 2025

Objective
Diabetes is characterized by high blood glucose concentration which leads to oxidative stress by auto-oxidation, resulting in pathological conditions like myocardial complications. This study is focused on evaluation of the protective potential of antioxidants against glucose/glucose oxidase (G/GO)-induced oxidative stress and cardiac cell damage.
Methods
H9c2 cells which is derived from cardiac muscles were exposed to 33mM glucose and 1.6 milliunits glucose oxidase for induction of oxidative stress. Apoptosis was evaluated through markers like phosphatidylserine accumulation, DNA damage, and esterase activity. Reactive oxygen and nitrogen species production, mitochondrial membrane potential loss, and cytochrome-c release assessed using confocal microscopy and FACS analysis. Antioxidants such as N-Acetyl Cysteine, catalase, and glutathione were tested for their protective effects. Western blot analysis was used to evaluate anti-apoptotic protein expression and MAPK pathway activation.
Results
G/GO exposure led to apoptosis in H9c2 cells, as evidenced by phosphatidylserine accumulation, DNA damage, and increased esterase activity. Reactive oxygen and nitrogen species production resulted in mitochondrial membrane potential loss and cytochrome-c release. Antioxidants successfully reduced free radical production, restored mitochondrial membrane potential, and prevented cytochrome-c release. Cell death inhibition, caspase activation and PARP cleavage was also done by the antioxidant. Furthermore, antioxidants restored levels of anti-apoptotic proteins (Bcl-2, Bcl-xL, cFLIP, XIAP, survivin) and inhibited Raf1, MEK1, and ERK1/2 activation in the MAPK pathway. Pharmacological inhibition of Raf1 reduced apoptosis.
Conclusion
Antioxidants exhibit strong protective efficacy against G/GO-induced oxidative stress by preventing mitochondrial dysfunction and inhibiting MAPK-mediated pathways, offering potential therapeutic benefits for oxidative stress-related cardiac damage in diabetes.
Anais SimpOdonto 2024 - III Simpósio em Odontologia da FOA/UNESP - Edição 2024
Authors: Alves Rezende Maria Cristina Rosifini , Salzedas Leda Maria Pescinini , Guiotti Aimée Maria
Published: February 2025

Caro(a) leitor(a), A Faculdade de Odontologia do Campus de Araçatuba, UNESP realizou nos dias 13 e 14 de dezembro de 20234 o SimpOdonto 2024 -“III Simpósio em Odontologia da FOA/UNESP”, com o tema “Odontologia no Século XXI - Avanços em Materiais Dentários”. Sob coordenação da Professora Associada Maria Cristina Rosifini Alves Rezende e Professoras Assistentes Doutoras Leda Maria Pescinini Salzedas e Aimée Maria Guiotti, o evento, além da apresentação de trabalhos acadêmicos, contou com 3 Minicursos com os temas “Cimento de Ionômero de Vidro - Indicações e aplicações na Odontologia do século XXI”, ministrado pelo Doutorando MSC. Gabriel Pereira Nunes; “Terapias em regeneração óssea aplicadas à biomateriais e superfícies de implantes dentários”, ministrado pela Pós-Doutoranda PhD. Hiskell Francine Fernandes e Oliveira e “Novas alternativas na regeneração pulpar”, ministrado pela Pós-Doutoranda PhD. Priscila Toninatto Alves de Toledo. O SimpOdonto 2024 - “III Simpósio em Odontologia da FOA/UNESP”, ao permitir o intercâmbio e difusão de conquistas e benefícios, resultantes de produção científica e tecnológica no meio acadêmico, potencializando a interlocução, interligando e conectando a Universidade com a sociedade, destaca a relevância social do ensino e da pesquisa em sintonia com as demandas sociais, respeitando o compromisso social da Unesp, ao mesmo tempo em que cria e recria conhecimentos, na medida em que se mostra sensível e capaz de contribuir para a transformação social, ao integrar e articular o espaço universitário com a comunidade. Profª.Associada Maria Cristina Rosifini Alves Rezende; Coordenação SimpOdonto 2024 - III Simpósio em Odontologia da FOA/Unesp
PRAWO RZYMSKIE I STORYTELLING, CZYLI O TOPOSIE GRECKIEJ GENEZY USTAWY XII TABLIC
Authors: Miśkiewicz Radosław
Published: February 2025

W artykule badam źródła antyczne przekazujące opowieści o tym, że Ustawa XII Tablic została opracowana na podstawie praw greckich poleis, w tym głównie praw Solona. Miały one zostać zdobyte dla decemwirów (łac. decemviri legibus scribundis) w czasie rzymskiego poselstwa do poleis w Grecji bądź w Italii. Uchwytna jest również tradycja, zgodnie z którą niejaki Hermodoros, wygnaniec z Efezu, miał pomóc decemwirom w spisaniu Ustawy. Nie zajmuję się, jak do tej pory czynili to badacze, udowodnieniem historyczności bądź uprawdopodobnieniem takiego poselstwa czy wpływu konkretnych praw Solona na instytucje z Ustawy XII Tablic. Interesuje mnie prawo rozumiane jako wytwór kultury, która w sferze wyobrażeniowej wytworzyła pewien topos stanowienia prawa. Schematy narracyjne o archaicznych prawodawcach (gr. „nomothetai”), przedstawione przez Andrew Szegedy-Maszaka, adaptuje do historii o genezie spisania Ustawy XII Tablic i walkach patrycjuszy z plebejuszami. Korzystając z narzędzi intelektualnych storytellingu, staram się odpowiedzieć na pytanie, co te historie mogą nam powiedzieć o świadomości Rzymian o swoim prawie oraz ich obrazie greckich prawodawców i „prawa greckiego”.
Biometria e tônus testiculares e concentrações séricas de testosterona em machos de antas brasileiras (Tapirus Terrestres) nos biomas Pantanal e Cerrado, Brasil
Authors:   , Brasil Andreza Vieira
Published: February 2025

Este estudo teve como objetivo contribuir para o conhecimento sobre a fisiologia reprodutiva
da Anta Brasileira (Tapirus terrestris) por meio da descrição das concentrações séricas de
testosterona, biometria testicular e tônus testicular de indivíduos que vivem nos biomas
Pantanal e Cerrado do Brasil, verificando a existência de sazonalidade para a espécie, e
investigando correlações entre esses parâmetros reprodutivos e idade e peso individual. Os
dados meteorológicos (temperatura do ar, velocidade do vento, umidade relativa e radiação
global) dos locais de estudo foram caracterizados por meio de estações automatizadas do
Instituto Nacional de Meteorologia (INMET). De 2015 a 2020, foram coletados dados de
campo de 22 e 11 antas selvagens machos dos biomas Pantanal e Cerrado, respectivamente.
Após a captura e contenção química, foram estimadas a idade e o peso dos animais. Amostras
de sangue foram coletadas para determinar as concentrações séricas de testosterona usando
radioimunoensaio. As medidas de biometria testicular incluíram largura, comprimento, altura
e volume, enquanto o tônus testicular foi atribuído usando pontuações de 3 (firme) a 1
(suave). A idade, o peso e as concentrações de testosterona dos animais não diferiram entre os
dois biomas (P > 0,05). Correlações positivas foram encontradas entre idade e peso (ρ = 0,86;
P < 0,001), e níveis séricos de testosterona com idade (ρ = 0,45; P = 0,0047) e peso (ρ = 0,51;
P = 0,0011). O volume testicular foi positivamente correlacionado com a idade (ρ = 0,75; P <
0,0001), peso (ρ = 0,65; P = 0,0011) e níveis séricos de testosterona (ρ = 0,42; P = 0,0081).
Além disso, o tônus testicular em indivíduos adultos (> 48 meses) foi significativamente
maior do que em indivíduos mais jovens (P < 0,05). A consistência testicular foi
positivamente correlacionada com o peso (ρ = 0,36; P = 0,0241) e os níveis séricos de
testosterona (ρ = 0,38; P = 0,0174). O efeito sazonal na reprodução da anta foi ausente, mas o
tônus testicular foi influenciado pela velocidade do vento (ρ = 0,37; P = 0,0211) e umidade do
ar (ρ = 0,37; P = 0,0262). Este estudo é a primeira descrição científica de parâmetros
reprodutivos de machos de Anta Brasileira.
Research Skills Reader
Authors: Hars Roelof
Published: February 2025

This reader is an adaptation of the fourth edition of Research Methods in Psychology by Jhangiani, Chiang, Cuttler & Leighton. It also adapts a chapter from Social Science Research: Principles, Methods and Practices, by Bhattatcherjee This work (and, for that matter, both books it adapts from) is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. The goal of this adaptation is to improve the fit of the material to the Research Skills pre-msc course, which focuses on business research rather than psychological research (though the disciplines share many similarities). To this end, this reader selects and adapts a set of relevant chapters from the original book. A more detailed list of changes can be found at the end of the book.

This reader is a ‘living document’, in the sense that material is changed on an annual basis to improve this fit with the course it is associated with.
Pap, waar ben je ... : Graflocatie al ruim tachtig jaar onbekend
Authors: De Witte Truus
Published: February 2025

Ze huilde toen ik haar onlangs belde over de Aprilmeistakingen van 1943: ‘Sorry dat ik nog steeds zo emotioneel ben, ik snap het niet, het is toch al zo lang geleden?’ Haar vader was tijdens die stakingen opgepakt en weggevoerd en, zo werd drie weken later door de bezetters gemeld, gefusilleerd en op een geheime plek begraven. Haar vader is nooit gevonden. Hij is vermist. Zij kon de geschiedenis niet verwerken en afsluiten. Na de zoveelste ‘Zit je nog steeds met die oorlog?’ hield ze zich maar stil. Net als andere nabestaanden van slachtoffers die, net als haar vader, érgens op een onbekende plek begraven liggen en nooit zijn gevonden.
BALI PAINTING MARKET: A BRIEF HISTORY AND EXPLORATION OF VARIOUS FACTORS AFFECTING ITS DEVELOPMENT
Authors: Karja I Wayan , Lei Tai
Published: February 2025

This article presents a brief history of the art market in Bali and explores the various factors that have influenced its development. We also examine how local culture, the tourist market, village networks, government policies, and the global art market have shaped the trajectory of Balinese art. These forces include the assumption of local culture to art, the commercialization along with the opening of the tourist market, the local network based on village lives, the state policy to promote Balinese art and culture, and the effects brought by the booming of the global art market dominated by financial capital. Local concepts with cultural specificity are pivotal in our analysis, for example, the role culture plays in art practice nowadays and before, and what influence it brings to the transformation from art for religious purposes to cultural products for commerce. In conclusion, we highlight that the Balinese art market stands apart from other local art markets worldwide due to its close connection with Bali's reputation as a renowned tourist destination. The interplay of dynamic forces has shaped the market's growth, structure, and uniqueness over the years.
Linguistic Analysis of the Chinese Network Neologisms “Xiaohaige”
Authors: Wu Mengdie
Published: February 2025

New words on the Internet are closely related to social development, reflecting the changes of the times and the psychology of the masses. This paper is mainly guided by the metaphor theory of cognitive linguistics, and takes the new Internet word “Xiaohaige” derived from social hot spots as the main research content. The paper first uses the semantic component analysis method to obtain the distinguishing features between the new Internet words “Xiaohaige”, “Xiaohai” and “Ge”, and then obtains the grammatical and pragmatic differences between the three through syntactic analysis and context. The study found that “Xiaohai” and “Ge” will have semantic conflicts, but the two can be cleverly combined and form new meanings in the conflict, thus launching a metaphor analysis from a cognitive perspective.
LAND TITLING AND HOUSEHOLD LABOR SUPPLY: EVIDENCE FROM MEXICO
Authors: Ayala Cantú Luciano
Published: February 2025

This paper uses a panel dataset of rural households and the roll-out of a nationwide land titling program in Mexico to explore the impact of tenure security on household labor supply. The results of this paper suggest that land titling decreased the number of hours in wage employment, but did not affect labor supply in own-farm agriculture. Moreover, cultivated land increased with the certification program. Suggestive evidence shows that the certification program reduced the number of children working on their own farms. The results are robust to several specifications and support the parallel trends hypothesis.
DESEMPEÑO DEL GASTO GUBERNAMENTAL Y CARENCIAS SOCIALES A NIVEL SUBNACIONAL, 2014-2022
Authors: Valdés Iglesias Edson , Cernichiaro Reyna Christopher , Méndez Salazar Marco Antonio
Published: February 2025

RESUMEN
Parte de la literatura empírica señala que la provisión gubernamental de salud, educación e infraestructura básica tienen efectos positivos para la reducción de las carencias sociales; pero es necesario analizar la eficiencia con la que se consigue tal propósito. Por ello, el objetivo de esta investigación es determinar si los recursos humanos en los sectores educativo y sanitario, y el gasto público destinado a infraestructura social, educación y salud han reducido eficientemente la vulnerabilidad por carencias sociales a nivel subnacional durante el periodo 2014 a 2022 en México. Se utilizaron análisis evolvente con productos indeseables y una medida de eficiencia basada en holguras para caracterizar niveles de eficiencia, exhibiendo diferencias regionales y temporales. Además, se analizó la importancia de cada rubro de gasto gubernamental y de recursos humanos mediante una red neuronal, resultando que los recursos destinados a la educación media y superior son los más importantes para determinar la eficiencia estatal al reducir las carencias sociales.
GOVERNMENT SPENDING PERFORMANCE AND SOCIAL DEPRIVATION AT THE SUBNATIONAL LEVEL, 2014-2022
ABSTRACT
Part of the empirical literature indicates that government provision of health, education and basic infrastructure have positive effects on social deprivation reduction; however, there is a need to analyze the efficiency in the achievement of this purpose. Therefore, the objective of this research is to determine whether human resources in the education and health sectors, and public spending on social infrastructure, education and health have efficiently reduced vulnerability due to social deprivation at the subnational level from 2014 to 2022 in Mexico. Data envelopment analysis with undesirable products and a slack-based efficiency measure were used to characterize efficiency levels, both showed regional and temporal differences. Additionally, the importance of each category of government spending and human resources was determined through a neural network, concluding that the resources allocated to secondary and higher education are the most important in determining state-level efficiency when the aim is to reduce social deprivation.
DINÁMICA DE EXPORTACIÓN, CADENAS DE VALOR Y PATRONES DE INDUSTRIALIZACIÓN EN MÉXICO Y COREA DEL, SUR 1995-2020
Authors: Landa Díaz Heri Oscar , Cerezo García Verónica
Published: February 2025

RESUMEN
El objetivo de este trabajo es examinar, mediante un modelo panel, el impacto de la integración a las cadenas globales de valor (CGV) en el desarrollo industrial (13 subsectores manufactureros) en México y Corea del Sur durante el periodo 1995-2020. Los resultados principales sugieren que: i) la deslocalización promueve efectos positivos sobre el desempeño industrial, aunque su magnitud es más relevante para la economía de Corea del Sur; ii) la posición dentro de las CGV determina la internalización de las ganancias dinámicas asociadas a la apertura; iii) el modelo de objetivo de inflación y la deflación salarial, en ausencia de una política industrial efectiva, han contribuido a la ralentización de la productividad y de la expansión del producto de México. Concluimos que la naturaleza del patrón de especialización industrial constituye un elemento determinante de la baja capacidad de arrastre y dispersión productiva del sector manufacturero.
EXPORT DYNAMICS, VALUE CHAINS AND INDUSTRIALIZATION PATTERNS IN MEXICO AND SOUTH KOREA, 1995-2020
ABSTRACT
The aim of this paper is to examine, through a panel model, the impact of integration into global value chains (GVCs) on industrial development (13 manufacturing subsectors) in Mexico and South Korea during the period 1995-2020. The main findings indicate that: i) offshoring promotes positive effects on industrial performance, although those effects are more relevant for South Korea; ii) the position within GVCs determines the internalization of the dynamic gains associated with openness; iii) the inflation targeting and wage deflation model, in the absence of an effective industrial policy, has contributed to slowdown productivity and output growth. Hence we conclude that the nature of Mexico’s industrial specialization pattern constitutes a determining element of the observed low drag and dispersion potential of the manufacturing sector.
Tipos de testamentos en el Código Civil del Distrito Federal aplicable a la Ciudad de México y el principio nemo pro parte... del derecho romano. Análisis y propuesta
Authors: Hernández Ríos Eduardo Daniel
Published: February 2025

En el presente artículo se explora la problemática de la cultura testamentaria en la Ciudad de México, evidenciada por la alarmante estadística de que solo el 9 % de los ciudadanos aptos para testar contaba con un testamento en 2005. Se analizan las iniciativas del gobierno local para fomentar esta cultura, incluyendo reformas al Código Civil que limitan los tipos de testamentos a uno solo, el público abierto, y las implicaciones de esta restricción. A través de un análisis crítico y una comparación con principios del derecho romano, se propone una reflexión sobre la efectividad de las reformas y la necesidad de un enfoque más integral en la materia de sucesiones, invitando a los lectores a profundizar en un tema que afecta directamente la seguridad jurídica de los ciudadanos.
La capacidad jurídica de las personas en estado de interdicción
Authors: Leyva Sánchez Jesús
Published: February 2025

De acuerdo con el contenido del Código Civil para la Ciudad de México, una persona con discapacidad puede ser declarada en estado de interdicción, provocando que su capacidad jurídica se vea limitada o restringida; ya que no podrá tomar decisiones más que a través de un tercero (llamado tutor), lo que se traduce en discriminación, pues se violentan sus derechos establecidos en la propia Constitución y en la Convención sobre los Derechos de las Personas con Discapacidad, los cuales establecen que todas las personas deben ser tratadas por igual.
Comparative study of quantum error correction strategies for the heavy-hexagonal lattice
Authors: Benito César , López Esperanza , Peropadre Borja , Bermudez Alejandro
Published: February 2025

Topological quantum error correction is a milestone in the scaling roadmap of quantum computers, which targets circuits with trillions of gates that would allow running quantum algorithms for real-world problems. The square-lattice surface code has become the workhorse to address this challenge, as it poses milder requirements on current devices both in terms of required error rates and small local connectivities. In some platforms, however, the connectivities are kept even lower in order to minimise gate errors at the hardware level, which limits the error correcting codes that can be directly implemented on them. In this work, we make a comparative study of possible strategies to overcome this limitation for the heavy-hexagonal lattice, the architecture of current IBM superconducting quantum computers. We explore two complementary strategies: the search for an efficient embedding of the surface code into the heavy-hexagonal lattice, as well as the use of codes whose connectivity requirements are naturally tailored to this architecture, such as subsystem-type and Floquet codes. Using noise models of increased complexity, we assess the performance of these strategies for IBM devices in terms of their error thresholds and qubit footprints. An optimized SWAP-based embedding of the surface code is found to be the most promising strategy towards a near-term demonstration of quantum error correction advantage.
Contorções no gênero policial por Ana Paula Maia e seus homens infames, de sangue e de fé
Authors: Coelho Lilian Reichert
Published: February 2025

Propõe-se uma aproximação às narrativas Enterre seus mortos (2018) e De cada quinhentos uma alma (2021), da escritora brasileira contemporânea Ana Paula Maia, por meio da intuição de que ela pratica uma sensibilidade fabular que aponta para possibilidades de igualdade ontológica geradas pelos seres humanos mais infames, que se insurgem de algum modo contra as condições de vida que lhes são impostas. A partir disso, defendo que Ana Paula Maia aciona performaticamente estratégias das narrativas policiais, contorcendo qualquer princípio organizador. A abordagem sustenta-se nas noções de comum, igualdade e partilha do sensível de Rancière e na ideia de “homens infames”, de Foucault.
Detetives transculturais: rompendo fronteiras na ficção criminal
Authors: Meanda Juliana Machado , Da Silva Rodrigues Diana
Published: February 2025

Este artigo traz uma análise das obras Eulogy for a Brown Angel (1992), de Lucha Corpi, e Mezcalero (2015), de T. E. Wilson. Buscamos compreender como seus detetives, Gloria Damasco e Ernesto Sánchez, respectivamente, levantam questões de identidade, especialmente em relação a gênero e etnia, e trazem ainda o multiculturalismo e a subalternidade dentro de seus contextos. Corpi nasceu no México e vive nos Estados Unidos, enquanto Wilson nasceu no Canadá e vive no México, e ambos escrevem suas ficções detetivescas em língua inglesa. A escrita destes autores é um espaço de resistência cultural, de expressão de diferenças e de representações identitárias alternativas de membros de grupos marginalizados pela sociedade dominante. Enquanto Damasco, mulher chicana, inicia seu percurso na investigação criminal como amadora, conciliando seus papeis de esposa e mãe, Sánchez, homem Trans, inicia seu trajeto como policial no Canadá e depois torna-se investigador particular no México. Com o auxílio de Schindler (2023) e Portilho (2009, 2016), dentre outros, analisamos como são abordadas as interseções entre essas duas personagens, especialmente no que tange a questões de gênero, evidenciando como elas subvertem a literatura detetivesca, que em sua faceta mais difundida ainda é predominantemente uma narrativa do homem branco cis hetero.
Movimentos do conhecimento em planos de aulas de língua inglesa para o estágio supervisionado
Authors: Costa Marco Antônio Margarido , Silva Camilla Estevam
Published: February 2025

Este trabalho tem como objetivo discutir os aspectos metodológicos empreendidos em práticas pedagógicas orientadas pela perspectiva dos letramentos, elaboradas por graduandos do curso de Letras – Língua Inglesa, da Universidade Federal de Campina Grande, matriculados na disciplina Estágio de Língua Inglesa: Educação Infantil e 1º e 2º ciclos do Ensino Fundamental. Esta pesquisa foi baseada nos estudos de Cope e Kalantzis (2009), Kalantzis e Cope (2005) e Kalantzis, Cope e Pinheiro (2020), sobre os movimentos do conhecimento (experienciando, conceitualizando, analisando e aplicando), pelos quais, segundo os autores, o conhecimento é construído. Para a realização da pesquisa, foram analisados planos de aula elaborados pelos graduandos, a fim de identificar os tipos de propostas pedagógicas executadas em cada plano e como essas propostas se alinhavam com os referidos movimentos. Nas análises desses planos, embora muitas ações sinalizassem procedimentos de um funcionamento tradicional de aulas presenciais, foi possível identificar movimentos do conhecimento que evidenciaram a criatividade e a inovação dos alunos, que estavam imersos em um contexto de ensino remoto provocado pela pandemia da covid-19.
Inteligência Artificial Gerativa, corpos “perfeitos” e colonialidade estética
Authors: Hashiguti Simone
Published: February 2025

Neste artigo, abordamos a geração de imagens por sistemas de inteligência artificial, problematizando a manutenção, por parte desses sistemas e em seus produtos gerados, de uma lógica colonial, a partir da qual são cristalizadas, por exemplo, algumas representações de beleza e perfeição que são irreais e pautadas num referencial branco, europeu e hegemônico. Para isso, mobilizamos teorias sobre discurso e corpo a partir das quais analisamos discursivamente seis imagens, geradas por tais sistemas, e discutimos as condições de possibilidade nas quais elas são geradas e seus efeitos. Tomando essa análise como exemplo de um funcionamento problemático e considerando que os sistemas de inteligência artificial podem funcionar como dispositivos de controle e manipulação de usuárias(os), apontamos para a necessidade de incluir a discussão direta e detalhada sobre inteligência artificial na sala de aula de línguas e de forma a responder efetivamente por uma orientação crítica de educação linguística.
A formação inicial de professores em tempos de Inteligência Artificial: foco nas percepções dos formadores
Authors: Molinari Andressa , Ramos Samantha
Published: February 2025

A formação inicial de professores em tempos de emergência de ferramentas de inteligência artificial (IA) tem sido tema recorrente nas práticas dos docentes, gerando um cenário de ansiedade. Este estudo tem por objetivo analisar as percepções dos professores formadores de Língua Inglesa no que se refere aos questionamentos e problemáticas advindas do uso da IA nas práticas pedagógicas da licenciatura. Para tanto, cinco professores formadores foram convidados a compartilhar suas percepções sobre os contextos de formação inicial nos quais atuam, no que se refere ao advento da IA. Para tratar desse tema, nos ancoramos nas teorias de letramentos, multiletramentos e em trabalhos recentes que abordam o letramento em inteligência artificial (IA) e formação de professores.  Promovemos um estudo qualitativo de caráter descritivo. A análise dos dados considerou as seguintes temáticas: 1) reconhecimento da existência das IA por parte dos docentes; 2) entendimento de seu funcionamento, potencialidades e fragilidades por parte de todos os envolvidos; 3) utilização para potencializar a aprendizagem/formação de professores; 4) dificuldade de acompanhamento do processo de aprendizagem do aluno quando a IA é utilizada para a realização das tarefas propostas; 5) os usos não éticos das ferramentas e suas consequências e 6) falta de repertório e capacidade crítica para avaliar o texto produzido pela IA.
Letramentos transmídia na Era da plataformização da educação
Authors: Câmara Naiá Sadi
Published: February 2025

Este artigo apresenta os resultados do projeto “Letramentos transmídia na era da plataformização da educação”, que tratava dos letramentos produzidos e circulados por alunos em cursos de formação profissional e inseridos no ensino remoto emergencial exigido pela pandemia covid-19. Com base na proposta teórico-metodológica dos Letramentos transmídia, identificamos como principais características da competência letrada dos alunos: são leitores ubíquos, dispersos, com graves problemas de leitura, interpretação e produção de textos complexos, sobretudo os teóricos e artísticos. Do ponto de vista da produção, transmissão e aquisição do saber, os dados revelam um ganho com o estar on-line, já que a internet abre possibilidades maiores de interação com o conhecimento de modo mais interativo.
Multiletramentos, Letramentos, IA e Questões da Sociedade Digital: entrevista com a professora Walkyria Monte Mor (USP)
Authors: Sousa Silvia Maria , Lacerda Rabello Cíntia Regina , Austin Windle Joel , Monte Mor Walkyria
Published: February 2025

Multiletramentos, Letramentos, IA e Questões da Sociedade Digital: entrevista com a professora Walkyria Monte Mor (USP)
Multiletramentos, novos gêneros, linguagens digitais, Inteligência Artificial: enfrentamentos teóricos e práticos
Authors: Sousa Silvia Maria , Lacerda Rabello Cíntia Regina , Austin Windle Joel
Published: February 2025

Apresentação à Cadernos de Letras 69.
Research on the quality of milk and yoghurts of the Blagoveshchensk retail chain
Authors:   Amur State University, Platonova Tatyana P.
Published: February 2025

The article presents the results of studying the dry matter content, the
mass fraction of moisture, sugars, calcium, active and titrated acidity in milk and
yoghurts of the Blagoveshchensk retail chain. Ammonia as a counterfeit was found
in the studied yogurts as a result of their improper storage in the retail network. Soda
was found in one sample of milk, hydrogen peroxide was absent in the product.
The benefits of pea protein isolate when used in healthy nutrition technologies
Authors:   Pushchinsky branch of the Russian Biotechnological University, Ulyanitskiy Yuri N. , Artyukhovа Svetlana I. ,   Pushchinsky branch of the Russian Biotechnological University
Published: February 2025

The article discusses the advantages of pea protein isolate when used
in food. Taking into account the content of valuable protein, the authors recommend
including pea protein in the composition of healthy food products, which is gaining
significant relevance in the global and Russian food industry.
The Association Between Residency Characteristics and Graduates Caring for Children: A Family Medicine Residency Outcomes Project
Authors: Barr Wendy B. , Peterson Lars E. , Fleischer Sarah , Bazemore Andrew W.
Published: February 2025

Background and Objectives: The proportion of family physicians caring for children is decreasing. At the same time, US family medicine residency training requirements have increased flexibility in how to train future family physicians in caring for this population. Our objective was to evaluate the correlation between residency program structures and curriculum with graduates caring for children.
Methods: We conducted a prospective cohort study of family medicine graduates using the 2018 Council of Academic Family Medicine Education Research Alliance program director study to measure program characteristics and pediatric curricular elements, and the 2021 family medicine National Graduate Survey (NGS) of residents who graduated in 2018 to measure outcomes. We used logistic regression to determine associations between residency elements and graduate practice of outpatient pediatrics, inpatients pediatrics, or newborn hospital care.
Results: After data from the two sources were merged, our final sample was 779 family medicine graduates (48% of the NGS sample), where 74.7% reported practicing outpatient pediatrics, 16.8% inpatient pediatrics, and 25.9% newborn care. In multivariate analyses, residency processes associated with the care of children in one or more settings included having more than 10% of continuity clinic patients under the age of 10 and having two or more family medicine faculty supervising inpatient pediatrics or newborn care.
Conclusions: In a large national cohort study, we found that residency processes—especially faculty role modeling care of children and the inclusion of children in continuity clinic—are positively associated with residency graduates providing care for children. With residency training requirements changing, these results offer evidence-based interventions for programs to produce graduates who will care for children.
Introduccion a la ciencia y análisis de datos con Python: una visión empresarial
Authors: Holguín Londoño German Andrés , Moreno Gallón Diego Alejandro , Holguín Londoño Mauricio
Published: February 2025

La actualidad está siendo marcada por una avalancha de datos y una evolución constante en el mundo empresarial. Todos los sectores económicos avanzan a pasos agigantados y el análisis de datos se ha convertido en una herramienta indispensable. Este libro está diseñado para ser una guía introductoria, práctica y accesible para aquellos en el sector empresarial, o curiosos del tema, que buscan adentrarse en el mundo del análisis de datos, proporcionando una comprensión fundamental y ejemplos sencillos de cómo los datos pueden ser utilizados para informar y mejorar las decisiones de negocios. Como primer propósito del libro, se busca desmitificar el análisis de datos, presentándolo no como un campo exclusivo para expertos en TI o estadísticos, sino como una competencia accesible y valiosa para una amplia gama de profesionales. Como segundo propósito, el libro se enfoca en la aplicación práctica, ofreciendo ejemplos que muestran cómo el análisis de datos puede resolver problemas; se explora cómo recolectar, limpiar y manipular datos utilizando Python, un lenguaje de programación que se ha establecido firmemente como un estándar, debido a su simplicidad y potencia. Se introduce al lector en herramientas como Pandas y otras bibliotecas de Python, que simplifican enormemente el proceso de análisis de datos. No obstante, más allá de la mera técnica, este libro también se sumerge en la interpretación y el análisis crítico, habilidades clave para convertir los datos en perspectivas (insights) accionables.
Enhancing hydrogen evolution reaction using transition metal atoms on 6,6,12-graphyne: A DFT study
Authors: Motaghi Fatemeh , Mohammadi-Manesh Hossein
Published: February 2025

The escalating global population and the urgent need for sustainable energy
solutions with minimal environmental impact have underscored the
significance of developing renewable energy sources. Hydrogen, as an energy
carrier and fuel, presents substantial advantages over other energy forms,
alongside diverse applications in medical treatments and the production of
critical chemicals like methane and methanol. Thus, hydrogen emerges as a
potential alternative to fossil fuel, offering a stable and clean energy
solution. In this study, we present a theoretical design of transition metal
(TM) anchored 6,6,12-graphyne (GY) based catalysts for the hydrogen
evolution reaction (HER) using density functional theory (DFT). Our findings
reveal that among all evaluated systems, cobalt single-atom catalyst (SAC)
anchored on 6,6,12-graphyne exhibit the highest thermodynamic stability and
superior HER catalytic performance, with a remarkably low ?GH+ value of
0.042 eV. We have investigated the density of states, HOMOs, LUMOs, electron
density, and band structures of our designed SACs. This work provides a
practical strategy for experimental groups to effectively tune the
electronic structures of catalysts and enhance their catalytic activity.
Repeated OGTT Versus Continuous Glucose Monitoring for Predicting Development of Stage 3 Type 1 Diabetes: A Longitudinal Analysis
Authors: Desouter Aster K. , Keymeulen Bart , Van de Velde Ursule , Van Dalem Annelien , Lapauw Bruno , De Block Christophe , Gillard Pieter , Seret Nicole , Balti Eric V. , Van Vooren Elena R. , Staels Willem , Van Aken Sara , den Brinker Marieke , Depoorter Sylvia , Marlier Joke , Kahya Hasan , Gorus Frans K. ,   Belgian Diabetes Registry
Published: February 2025

OBJECTIVE

Evidence for using continuous glucose monitoring (CGM) as an alternative to oral glucose tolerance tests (OGTTs) in presymptomatic type 1 diabetes is primarily cross-sectional. We used longitudinal data to compare the diagnostic performance of repeated CGM, HbA1c, and OGTT metrics to predict progression to stage 3 type 1 diabetes.

RESEARCH DESIGN AND METHODS

Thirty-four multiple autoantibody-positive first-degree relatives (FDRs) (BMI SD score [SDS] <2) were followed in a multicenter study with semiannual 5-day CGM recordings, HbA1c, and OGTT for a median of 3.5 (interquartile range [IQR] 2.0–7.5) years. Longitudinal patterns were compared based on progression status. Prediction of rapid (<3 years) and overall progression to stage 3 was assessed using receiver operating characteristic (ROC) areas under the curve (AUCs), Kaplan-Meier method, baseline Cox proportional hazards models (concordance), and extended Cox proportional hazards models with time-varying covariates in multiple record data (n = 197 OGTTs and concomitant CGM recordings), adjusted for intraindividual correlations (corrected Akaike information criterion [AICc]).

RESULTS

After a median of 40 (IQR 20–91) months, 17 of 34 FDRs (baseline median age 16.6 years) developed stage 3 type 1 diabetes. CGM metrics increased close to onset, paralleling changes in OGTT, both with substantial intra- and interindividual variability. Cross-sectionally, the best OGTT and CGM metrics similarly predicted rapid (ROC-AUC = 0.86–0.92) and overall progression (concordance = 0.73–0.78). In longitudinal models, OGTT-derived AUC glucose (AICc = 71) outperformed the best CGM metric (AICc = 75) and HbA1c (AICc = 80) (all P < 0.001). HbA1c complemented repeated CGM metrics (AICc = 68), though OGTT-based multivariable models remained superior (AICc = 59).

CONCLUSIONS

In longitudinal models, repeated CGM and HbA1c were nearly as effective as OGTT in predicting stage 3 type 1 diabetes and may be more convenient for long-term clinical monitoring.
Nota introdutória: a ordem mundial em desordem – o regresso global da guerra e o fim da paz
Authors: Marcos Daniel , Daehnhardt Patricia
Published: February 2025

O quadro geopolítico contemporâneo está em profunda mutação. O regresso do fenómeno da guerra entre os Estados e o retorno de conflitos armados em diversas regiões do mundo, numa intensidade e interligação não testemunhadas desde há décadas, leva-nos a questionar os pilares da ordem internacional criada desde o fim da Segunda Guerra Mundial. A guerra da Rússia contra a Ucrânia ameaça a estabilidade da ordem de segurança euro-atlântica, mas não pode ser desarticulada da crescente instabilidade na Ásia Oriental, fruto da estratégia assertiva da China sobre Taiwan e Estados vizinhos. Por seu turno, a guerra em Gaza tem implicações para o Médio Oriente e para a crescente competição geopolítica entre as grandes potências. A intensificação destas guerras e destes conflitos e a afirmação de potências autocráticas revisionistas exacerbam tensões históricas e produzem repercussões sobre temas que vão para além das considerações tradicionais de segurança, como a segurança de infraestruturas críticas, a segurança marítima ou energética, ou as migrações. Os artigos deste dossiê resultam da análise que os oradores do Curso de Verão do IPRI-NOVA 2024 fizeram sobre «O regresso global da guerra: o fim da paz e a ordem mundial em desordem» e contribuem para a tentativa de mapeamento da emergente ordem geopolítica global resultante do fim da era do pós-Guerra Fria.
Afeganistão: da solidificação do regime talibã às possibilidades de reconciliação. Testemunhos da diáspora
Authors: Alexandre Ricardo
Published: February 2025

Que Afeganistão temos hoje, mais de três anos após o regresso dos talibãs ao poder? De que forma se materializa o que aparenta ser uma solidificação do regime? Qual o papel e impacto das sanções internacionais sobre as autoridades locais ilegítimas e sobre a população? Este artigo procura dar um conjunto de respostas possíveis a estas questões, considerando a realidade política e socioeconómica afegã, com base nos instrumentos documentais disponíveis e centrando o texto em testemunhos em primeira mão, a partir de entrevistas com afegãos na diáspora. Procura-se igualmente problematizar a viabilidade de um diálogo intra-afegão, como possibilidade de abertura de um processo de reconciliação nacional, que liberte o Afeganistão das amarras do parcial isolamento internacional e da crise humanitária profunda em que se encontra.
50 anos de relações diplomáticas Brasil-China: da parceria estratégica à interdependência assimétrica
Authors: Çoban Hazal Melike
Published: February 2025

Este estudo oferece uma análise abrangente das relações Brasil-China ao longo de seus cinquenta anos de história diplomática, com ênfase no século XXI. O artigo apresenta o contexto histórico das relações de 1974 a 1993, culminando no estabelecimento de uma parceria estratégica. Em seguida, aborda as dinâmicas dessa parceria durante a década de 1990. Por fim, trata a evolução dos laços econômicos e políticos, destacando o aumento significativo das relações comerciais e dos esforços colaborativos em organizações multilaterais desde o início dos anos 2000 até os dias atuais. A questão central refere-se à transformação das relações Brasil-China, explorando a transição de uma parceria estratégica para uma interdependência assimétrica.
Assessment of the triple-bottom line for development and management of human settlements: Case study of ward 12, uMlalazi local municipality, South Africa
Authors: Sangweni Siyabonga Senzesihle , Ntakana Khululekani , Mbanga Sijekula
Published: February 2025

The global adoption of sustainable development practices is gaining momentum, with an increasing emphasis on balancing the social, economic, and environmental pillars of sustainability. This study aims to assess the current state of these pillars within the uMlalazi Local Municipality, South Africa, and evaluate the initiatives in place to address related challenges. The purpose is to gain a deeper understanding of how effectively these three pillars are being addressed in the context of local governance. Using qualitative research methods, the study gathered data from a sample of five key informants, including three local government officials, one councillor, and one chief information officer from the local police. Data was collected through open-ended interview questions, with responses recorded, transcribed, and analysed for thematic content. The findings reveal significant gaps in the municipality’s approach to sustainability, including the absence of formalized trading areas, limited community input in planning and decision-making, high crime rates, and persistent unemployment. These issues were found to be interlinked with other challenges, such as inefficiencies in solid waste management. Additionally, the study confirms that the three pillars of sustainability are not treated equally, with economic and social aspects often receiving less attention compared to environmental concerns. This highlights the need for the municipality to focus on formalizing trading areas, encouraging local economic growth, and enhancing public participation in governance. By implementing incentives for greater community involvement and addressing the imbalances between the sustainability pillars, uMlalazi can make significant progress toward achieving more sustainable development.
Evaluation of a killed feline panleukopenia virus vaccine against canine parvoviral enteritis in dogs
Authors: Wierup Martin , Olson Pekka , Hedhammar Ake , Klingeborn Berndt , Karlsson Karl-Axel
Published: February 2025

Immunogenic potency of a killed feline panleukopenia virus vaccine against canine parvoviral enteritis in dogs was examined. The vaccine elicited hemagglutination-inhibition antibodies to canine parvovirus (cpv) in all of the 72 dogs which were vaccinated. The vaccine was protective in dogs against both experimentally induced and naturally occurring cpv-induced disease. By statistical analysis, 4 weeks was found to be the optimal spacing between 2 vaccinal doses resulting in hemagglutination-inhibition antibody titers up to 1:5,120. Adverse reactions to the vaccine were not observed. Atypical lymphocytes were found consistently in the cpv-infected control dogs.
Influence of physical exercise on plasma creatine kinase activity in healthy and dystrophic turkeys and sheep
Authors: Tripp Martha J. , Schmitz John A.
Published: February 2025

Plasma creatine kinase (p-ck) activities were significantly increased after physical exercise in healthy turkeys and in turkeys with genetic muscular dystrophy. Activities as high as 100,500 mU/ml of plasma were observed. Activities remained high for at least 29 hours after exercise. Moderate exercise did not significantly affect p-ck activity in lambs. Increases in p-ck activity during expression of nutritional muscular dystrophy were readily distinguished from exercise effects; activity exceeded 160,000 mU/ml in lambs during expression of that condition.
Evaluation in swine of a subunit vaccine against pseudorabies
Authors: Maes Roger K. , Schutz Jeffrey C.
Published: February 2025

A subunit vaccine against pseudorabies virus (prv) was prepared by treating a mixture of pelleted virions and infected cells with the nonionic detergent Nonidet P-40 and emulsifying the extracted proteins in incomplete Freund's adjuvant. Three 7-week-old pigs without antibodies against prv were given 2 im doses of this vaccine 3 weeks apart. Thirty days after the 2nd vaccination. 106 median tissue culture infective doses (tcid50) of a virulent strain of prv were administered intranasally. Tonsillar and nasal swabs were collected daily between 2 and 10 days after challenge exposure. The pigs vaccinated with the subunit vaccine were not found to shed virulent prv. Two groups of five 7-week-old pigs vaccinated with commercially available vaccines, either live-modified or inactivated virus, and subsequently exposed to 106 tcid50 of virulent prv, shed virulent virus for up to 8 days. Hie subunit vaccine induced significantly higher virus-neutralizing antibody titers than either the live-modified or inactivated virus vaccine.
Comparison of hemagglutination and competitive enzyme-linked immunosorbent assay procedures for detecting canine parvovirus in feces
Authors: Mathys A. , Mueller R. , Pedersen N. C. , Theilen G. H.
Published: February 2025

A competitive enzyme-linked immunosorbent assay (elisa) for detection of canine parvovirus (cpv) antigen in fecal samples was developed. Fecal samples were tested by elisa and a direct hemagglutination assay, and the results compared. The tests gave the same results in 83% and 88% of the fecal samples, depending on whether the samples were treated with chloroform. The discrepancies were due to the fact that each test detected virus in certain fecal samples that was not detected by the other. The use of a monoclonal anti-cpv conjugate resulted in a highly specific test. The performance of the elisa as a competitive assay also increased the reproducibility and sensitivity over that which could be obtained from a classic sandwich-type procedure.