bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengaruh Pendidikan Kesehatan Terhadap Pengetahuan Kader Posyandu Tentang Pencegahan Stunting
Authors: Tri Astuti Dian Septyana , Ratnawati Riska
Published: August 2023

Stunting is a chronic nutritional problem characterized by a short body (stunted). Health education is held as a learning effort to improve the Posyandu cadres’ knowledge of stunting prevention. The Posyandu cadres’ role is vital to the early prevention of stunting. This study aimed to figure out the influence of health education on Posyandu cadres’ knowledge of stunting prevention in Keniten urban village, Ponorogo. The Posyandu in Keniten Ponorogo Village is divided into seven areas. The research was conducted using a quantitative type with a cross sectional time approach. The total population is 35 Posyandu cadres for toddlers, where each Posyandu consists of five Posyandu cadres. Before being given education about stunting prevention, a pre-test was carried out to posyandu cadres. Health education is carried out using lecture and discussion methods, then at the end of the activity a post test is given. The result showed a significant improvement in the cadres’ knowledge level before and after giving health education with an average score of 81 increased to 90. The statistical test result showed a p-value of 0.005 (≤0.05), indicating a significant effect of health education on Posyandu cadres’ knowledge level of stunting prevention in Keniten urban village. The improvement on posyandu cadres’ knowledge of stunting prevention level happens due to health education. Providing information on stunting prevention or conducting training regularly by the Community Health Center to the Posyandu cadres to improve their knowledge to be better.
Edukasi Pemanfaatan Tanaman Obat Keluarga: Jeruk Kingkit (Triphasia trifolia) sebagai Alternatif Obat Batuk
Authors: Nurfitriyana Nurfitriyana , Yanuarti Rini , Ekadipta Ekadipta
Published: August 2023

Family medicinal plants (TOGA) are plants grow in home garden and can be used to improve the quality of health, prevention and alternative treatment. Cough is a body defense by the lungs against physiological reflexes to chemicals, temperature, air and mechanical trauma. Environmental conditions in the West Jakarta area such as motor vehicle fumes, smoke from , changes of weather have resulted in large frequency coughing. Kingkit citrus plants growned in West Jakarta, which can be an alternative cough medicine because they contain essential oils, linalool and limonene. The purpose of the  activity educated the public about the use of the jaruk kingkit plant as alternative cough medicine and educated how to present/make cough medicine from kingkit oranges. The service method used is survey and identification of TOGA, preparation, counseling and workshops of kingkit oranges and demonstration of its processing. This activity lasted for 3 days (Friday-Sunday 17-20 September 2021 at Taman Sehati Al-Fadillah, Central Jakarta. This activity involved 24 students from the ISTA Jakarta. The activity went well and a lot parties involved and supportive, both from the ISTA Jakarta mayor's ethnic group, the Jakarta office tribe. The community and village officials are  enthusiastic about participating in this activity. The conclusion from this activity is that  community can use the surrounding plants for alternative health and use Kingkit Orange for alternative medicine cough
Pelatihan Pengelolaan Sampah Berbasis Masyarakat Di Kelurahan Kampung Makassar Timur
Authors: Nagu Nani , Latif Lita Asyriati
Published: August 2023

One of the areas in Ternate City, namely Kampung Makasar Timur, where most of the population live above the water, so it seems that this area looks slum because there is no good solid and liquid domestic waste management system. This problem needs to be overcome by systematic, comprehensive, and sustainable waste management which includes reducing and handling waste from its source, namely the community. The purpose of this activity is to help the community by providing explanations and. increasing public insight about the household waste management system, the environment, increasing community participation in the waste management system and promoting household-based waste management as an effort to preserve the environment, this community service activity begins by observing the location of community service to determine the source and volume of waste generation , take an approach to the community, especially among housewives through Dasawisma activities then provide guidance and counseling, to increase awareness and community participation in waste management by utilizing community gathering media at the kelurahan location. Furthermore, he taught the community how to sort waste by type by making Takakura baskets as a household compost producer.
Transplantasi Terumbu Karang Menggunakan Media Bioreeftek Di Perairan Pulau Dodola Kabupaten Pulau Morotai
Authors: Koroy Kismanto , Wahab Iswandi , Alwi Djainudin , Nur Rinto M , Nurafni Nurafni , Asyâ€™ari Asyâ€™ari
Published: August 2023

Coral reefs and all the life in them is one of the natural wealth owned and priceless. However, based on the research results, the condition of dead coral in the waters of Dodola Island by 4% caused by the anchor of the ship. To reduce damage to coral reef ecosystems that continue to be developed today is to apply coral transplant techniques. The purpose of community service activities is to understand planting techniques and socialization of the role and function of coral reefs to tourists on the importance of coral reefs in Dodola water. The devotional activities include design, preparation of materials tools, manufacturing and harvesting of coral seeds, and installing seeds in bioreeftek media. Socialization and understanding of biographic coral reef transplant technology are carried out on the community, especially tourists. Before the activity is carried out, generally, the public does not know the importance of coral reefs and the benefits of transplantation. After socialization, the community begins to understand and understand the importance of coral reefs
Pengenalan Dan Pelatihan Computer Aided Engineering Menggunakan Software Abaqus Bagi Karyawan Konsultan Di Maluku Utara
Authors: Tata Arbain , Kusnadi Kusnadi , B Sukiman , Darwis Muhammad
Published: August 2023

Peningkatan kualitas sumber daya manusia di bidang pendidikan menjadi fokus tujuan dalam kegiatan pengabdian masyarakat ini. Melalui pelatihan software Abaqus, kualitas sumber daya manusia pada karyawan konsultan di maluku utara diberikan pemahaman dan pengetahuan tentang software Abaqus yang 79% dari peserta belum pernah mengetahui software tersebut sebelumnya. Dengan metode ceramah, tanya jawab, demonstrasi dan praktek diberikan dalam penyajian materi. Kegiatan pelatihan diselenggarakan pada hari sabtu, tanggal 27 November 2021. Kegiatan dilaksanakan di laboratorium computer aided enginerring (CAE)-fakultas teknik, universitas khairun ternate. Materi pelatihan berisi tentang pengenalan software Abaqus, simulasi 2D dan simulasi 3D part, assembling dan mesh. Hasil dari pelatihan software Abaqus ini diperoleh nilai kepuasan 58% dengan skala penilaian sangat baik untuk fasilitator, sedangkan untuk skala penilian baik 51% untuk fasilitas dan 52% pemateri.
Pembuatan Peta Kelurahan Sasa â€“ Kota Ternate Dengan Sistem Informasi Geografis
Authors: Latif Lita Asyriati , Nagu Nani , Wahidin Nurhalis
Published: August 2023

Pelaksanaan pembangunan desa sangat membutuhkan sebuah data penunjang informasi spasial berupa peta desa, sesuai dengan amanat Undang-undang Nomor 6 Tahun 2014 tentang Desa. Kegiatan ini bertujuan untuk memetakan kelurahan Sasa secara detail yang bermanfaat untuk mengetahui posisi desa terhadap kawasan di sekitarnya, melihat potensi desa, dan, membantu perencanaan pembangunan infrastruktur desa sebagai dasar informasi untuk integrasi spasial pembangunan wilayah. Kelurahan Sasa terletak di kecamatan Ternate Selatan, saat ini permasalahan yang dihadapi yaitu belum adanya peta keluarahan yang tersedia dalam bentuk digital yang menyajikan data secara aktual. Hal ini juga dikarenakan belum adanya kemampuan sumberdaya manusia (staf kelurahan) untuk membuat peta digital. Terkait dengan hal tersebut maka perlu merancang kebijakan pembangunan desa/kelurahan dengan mengacu pada pemetaan wilayah. Peralatan yang digunakan yaitu pesawat tanpa awak (drone) yang digunakan untuk pengambilan foto udara; perangkat komputer dengan sotware ArcGIS yang digunakan untuk pengolahan data foto udara, GPS untuk penentuan koordinat, dan seperangkat alat tulis untuk mancatat data hasil identifikasi di lapangan. Adapun hasilnye berupa peta hardcopy Kelurahan Sasa.Â  Hasil pemetaan ini terdiri dari batas kelurahan, permukiman dan fasilitas umum dan lokasi serta inset gambar pada peta sehingga memudahkan masyarakat untuk mengakses dan mengetahui fasilitas umum yang ada di Kelurahan Sasa. Peta tersebut diserahkan secara simbolis kepada Lurah sasa.
Sosialisasi Kesehatan dan Keselamatan Kerja (K3) kepada Kelompok Sadar Wisata di Kelurahan Kastela â€“ Kota Ternate
Authors: Imran Imran , Gaus Abdul , Hakim Raudha
Published: August 2023

Pengembangan kawasan wisata di Kota Ternate manjadi salah satu program pemerintah kota saat ini. Beberapa destinasi wisata terutama wisata pantai telah dikelola secara berkelompok oleh masyarakat setempat dengan membentuk kelompok sadar wisata. Namun demikian pengetahuan dan pemahaman kelompok ini masih terbatas terutama terkait dengan keselamatan dan Kesehatan kerja. Oleh karena itu kegiatan pengabdian dalam bentuk sosialisasi ini bertujuan untuk meningkatkan pemahaman kesiapsiagaan dan kesadaran masyarakat dan menumbuhkan peran komunitas masyarakat dalam mewujudkan ketangguhan masyarakat menghadapi kecelakaan. Luaran dari kegiatan ini adalah peningkatan pengetahuan dan wawasan Kesehatan dan Keselamatan Kerja bagi peserta pengelola kawasan wisata pantai Kastela Kota Ternate
Save Our Beach: Kawasan Wisata Pulau Galo-Galo, Kecamatan Morotai Selatan, Kabupaten Pulau Morotai
Authors: M. Nur Rinto , Asyâ€™ari Asyâ€™ari , Tjiroso Bambang , Umar Ardin , Arisetiawan Arisetiawan
Published: August 2023

Morotai merupakan salah satu wilayah strategis, terutama dalam pengembangan pariwisata berbasis pantai. Beberapa icon wisata pantai yang dimiliki Morotai diantaranya Pulau Dodola, Pulau Kolorai, Pulau Kokoya, Pulau Zum-zum, Pantai Nunuhu, Tanjung Gorango, Tanjung Dehe Gila, Pantai Batu Lobang, dan beberapa tempat lainnya. Namun tidak kalah menariknya adalah pantai yang berada di Pulau Galo-Galo. Pulau Galo-galo merupakan kawasan pantai yang sangat potensial tapi masih belum terkelola dengan baik. Kawasan pantai ini memiliki daya tarik karena merupakan pulau kecil yang dikelilingi pasir putih dengan air laut yang hijau kebiruan. Namun, masalah kebersihan pantai menjadi problem utama yang membuat pantai ini memiliki selling point yang lemah. Tujuan kegiatan ini dapat menanamkan pemahaman masyarakat sejak dini dan sebagai pemacu semangat masyarakat Galo-Galo agar dapat menerapkan pola hidup bersih dan menciptakan pantai yang bersih dan indah sebagai kawasan wisata bahari. Kegiatan ini diharapkan dapat menumbuhkan kesadaran masyarakat sejak dini tentang pentingnya menjaga kebersihan lingkungan terutama pantai yang dijadikan sebagai kawasan wisata dengan cara pemberian pemahaman kepada siswa SD, MTs dan masyarakat umum di Desa Galo-Galo. Selain itu, tim pengabdian beserta masyarakat Desa Galo-Galo turun ke lapangan, bersama-sama membersihkan pantai untuk menciptakan pantai yang bersih dan indah
Program Kelengkapan Jalan Safety Parking Sign Berdasarkan Standar Srp Untuk Mendukung Infrastruktur Wisata Pantai Ancol Plengsengan Lateng
Authors: Wari Wahyu Naris , Suryani Erna , Jannah Reni Nur
Published: August 2023

Pantai Ancol Plengsengan Desa Lateng Banyuwangi merupakan salah satu pantai tujuan wisata khususnya untuk masyarakat lokal di Kabupaten Banyuwangi. Namun karena belum memiliki sistem pengelolaan parkir yang baik, sehingga kawasan ini menjadi kurang nyaman karena sesak dengan kendaraan â€“ kendaraan pengunjung yang berhenti di depan masing masing warung bahkan di jalan, sehingga menghambat mobilisasi pengunjung. On street Parking menjadi salah satu indikasi penyebab menurunnya kinerja jalan terutama pada jam puncak yang mengakibatkan arus lalulintas menjadi macet. Oleh karena itu solusi untuk menyediakan fasilitas parkir di luar badan jalan (off street parking). Kegiatan yang dilaksanakan adalah survey, pemasangan paving dan Penggambaran petak parkir dalam SRP dan penyerahan rambu sebagai fasilitas pelengkap parkir.
PENGARUH DAYA TARIK WISATA DAN FASILITAS LAYANAN TERHADAP KEPUASAN WISATAWAN (WISATA TANJUNG PEJUANG DESA TUADA)
Authors: Hallo Friskila , Hidayanti Ida , Hi. Yusuf Ibnu Sina
Published: August 2023

ABSTRACTObjective: This research purposed to identify the influence of Attraction and Service Facilities on Tourist Satisfaction in Tajung Pejuang Desa Tuada Beach. This research type is an explanatory research with quantitative approach. Data were collected by using questionnaires distributed to the 100 tourists who have visited to Tanjun Pejuang Desa Tuada Beach by simple random sampling technique.Methodology: Data analysis are used consist of descriptive analysis, classic assumption test, multiple linier regression analysis, F test and t test. Finding: H1 and H2 accepted at the 5% 10% confidence level.Conclusion: The result of this study showed that Attraction and Service Facilities simultanously have a significant effect on Tourist Satisfaction, AttractionÂ  has a significant effect on Tourist Satisfaction, and Service Facilities has a significant effect on Tourist Satisfaction. Â
PERBANDINGAN ABNORMAL RETURN SAHAM SEBELUM DAN SESUDAH STOCK SPLIT DI BURSA EFEK INDONESIA 2014-2018
Authors: Wonggo Denia Septiana , Hadady Hartaty , Pratama Rheza
Published: August 2023

Objective: Comparison of Abnormal Stock Returns Before and After Stock Split on the Indonesia Stock Exchange. The sample in this study used a purposive method. Based on the sample selection in accordance with the specified criteria, the number of samples in this study were 40 companies or as many as 200 units of observation within a period of 5 years.Methodology: The analytical method used in this study is the Test Difference method.Finding: Hypothesis accepted at the 5% confidence level.Conclusion: The results showed that abnormal returns had a positive and significant effect before and after the stock split. Because an increase in abnormal stock returns before and after the stock split.
SIGNIFIKANSI NILAI PERUSAHAAN MELALUI VARIABEL INTELLECTUAL CAPITAL DAN KINERJA KEUANGAN PADA PERUSAHAAN INDEKS LQ45
Authors: Bayau Fajrul Rahman , Sirat Abdul Hadi , Hadady Hartaty
Published: August 2023

Objective: This study aims to determine the significance of the firm value through the variable Intellectual capital and financial performance as an intervening variable in LQ45 companies listed in Indonesia Stock Exchange, with a sample of 20 companies.Methodology: The analytical method used is path analysis. The observation time was 5 years and the research data is secondary data by using purposive sampling method. In this research, intellectual capital is measured with a VAIC, financial performance measured by ROA, and the company's value is measured by Tobin's Q.Finding: Ha1, Ha2, and Ha3 are rejected, at the 5% confidence level.Conclusion: The results of this study indicate that intellectual capital has a positive effect on the financial performance, financial performance has a positive effect on corporate value, intellectual capital directly positive effect on the firm value, and financial performance is able to mediate the relations of intellectual capital on firm value even if the direct effect is greater than the indirect effect.
PENGARUH BUDAYA ORGANISASI TERHADAP KINERJA PEGAWAI: KNOWLEDGE SHARING SEBAGAI MEDIASI
Authors: Saino Rosita , Rajak Adnan
Published: August 2023

Objective: The purpose of this study is to know and analyze: (1) The influence of organizational culture positively and significantly on the Performance of Employees; (2) The positive and significant influence of organizational culture on knowledge sharing; (3) The effect of knowledge sharing positively and significantly on Employee Performance; and (4) The influence of organizational culture on Employee Performance through knowledge sharing at the Regional Office of the Ministry of Religion of the Province of North Maluku. The number of research samples were 92 employees.Methodology: The test instrument used was a structural equation model (SEM) using Partial Least Square (PLS) as a statistical test tool.Finding: Ha1, Ha2, and Ha3 are rejected, at the 5% confidence level.Conclusion: The results showed that: (1) Organizational culture had a positive and significant effect on employee performance at the Regional Office of the Ministry of Religion, North Maluku Province; (2) Organizational culture has a positive and significant effect on knowledge sharing at the Regional Office of the Ministry of Religion of the Province of North Maluku; (3) Knowledge sharing has a positive and significant effect on employee performance in the Regional Office of the Ministry of Religion of the Province of North Maluku; (4) Organizational culture has a positive and significant effect on employee performance through employee knowledge sharing at the Regional Office of the Ministry of Religion of the Province of North Maluku
Kesesuaian Lahan Padang Rumput Imperata untuk Penggembalaan Di Provinsi Maluku Utara
Authors: Soraya Dahlia Aprilia , Hadun Ramli , Teapon Amiruddin , Hoda Abdurrahman
Published: August 2023

Imperata land usually left abandoned. Destruction of forest and abandonend land impacted to the expansion of the imperata lands. Imperata lands also trigger a fire. Therefore, this research pushed utilization of imperata lands for grazing.This research to study data of land sustainability and recommendation for development of grazing. Methodology used are purposive random sampling technic of land survey by spatial mapping and followed by physical and chemical test of soils.Â The suitable land for beef cattle herding system 2.114,8 ha, 1.822,9 ha for cowshed system, 1.822,7 ha for the development of animals forage, 1.557,0 ha for dry food producing plants, and 1.298,0 ha for peanut plants.Keywords: Land suitability, imperata, grazing.
Pengaruh Aplikasi Mikoriza Arbuskular dan Media Tanam Terhadap Pertumbuhan Kelapa Bido di Kebun Rehabilitasi
Authors: Aji Himawan Bayu , Tjokrodiningrat Suryati , Sulistiono Wawan
Published: August 2023

The North Maluku region is famous for its agricultural sector, sub-sector of coconut plantations. However, there are various problems that become challenges in efforts to increase coconut production in North Maluku. The purpose of the study was to obtain information on morphological characteristics and growth related to the dose of arbuscular mycorrhizal fungi and the composition of the growing media. The research was conducted at the North Maluku Plantation (BPTP) from August 2019 to February 2020. The study used a factorial of 2 factors, namely the dose of JMA and the composition of the growing media. The first factor is the dose of JMA which consists of 3 levels of M1 (2g); M2 (4g); and M3 (6g). The second factor is a combination of 3 levels of planting media; manure (PK): sawdust (SG): sand (Ps). Data were analyzed using variance (analysis of variance). The results showed that the combination of treatment with a dose of JMA and a certain planting media could stimulate the growth of plant height, stem circumference, number of variables, and the highest crown length at the age of 6 bst.Keywords: bido coconut, arbuscular mycorrhizal fungi, growing media, morphological and growth characteristics
Karakteristik dan Kualitas Daging Sapi di Rumah Potong Hewan (RPH) Kota Ternate
Authors: Afrita Fenny , Talebe Yusnaini B. , Hoda Abdurrahman
Published: August 2023

The present study aimed at analyzing the weight of beef cattle meat at different ages, the carcass and percentage of the carcass of beef cattle using the Schoorl prediction formula and scale measurement, as well as examining the quality of beef cattle meat from the slaughterhouse. The samples were taken from 16 beef cattle. The quality of the meat was observed on the parts of leg, breast, and chuck of the cattle that were stored at the temperature of -20Â°C. The observation on the quality of the meat was carried out to find out the Total Plate Count (TPC), Water-holding Capacity (WHC), cooking shrinkage, and the pH of the meat. The results showed that samples from the 16 beef cattle consist of Ongole grade cattle and Balinese cattle within the age range of 3 - 6 years old. The weight of the beef cattle predicted with the Schoorl formula ranged from 222,84 to 298,50 kg, whilst the weight on the scale measurement basis indicated a range between 134,83 and 195,60 kg. The statistical analyses showed a significant difference (P0.05) between the carcass percentage calculated from the Schoorl prediction formula and from the scale measurement with a deviation of 12,340%. Yet, the TPC values showed an insignificant difference among the 16 beef cattle. Further, the quality of meat parts had an interaction with the length of storing in association with the cooking shrinkage of the beef cattle meat.Keywords: beef cattle weight, carcass, cooking shrinkage
Uji penurunan nilai C/N rasio dan kecepatan proses pengomposan tandan kosong kelapa sawit pada beberapa komposisi kotoran sapi
Authors: Rizkysandy Ilham Manggala , Kristalisasi E. Nanik , Syah Ryan Firman
Published: August 2023

The research was conducted to know different proportions of cow dung affect the C/N ratio and composting time of empty palm oil bunches is the focus of this study. The study was carried out in Nanggulan Village, Maguwoharjo, Depok, Sleman, Yogyakarta, from March to May 2022. Non-factorial Completely Randomized Design (CRD) with six levels was used to set up this study's factorial experiment including empty oil palm bunches at 100%, 90%, and 0%. Oil palm bunches (empty): 80%, cow manure (10%) The ratio of cow manure to palm fruit bunches is 80:20. 70% empty palm fruit bunches, 30% cow manure 40 percent dried manure from cows, 50 percent dried palm fruit bunches Halves of cow manure. One-way ANOVA was used to examine the study's results. Least Significant Difference (LSD) was used to further test for differences between treatments at the 5% significance level. According to the findings, the C/N ratio was reduced to a best trend of 18.56 in the treatment of 50% empty palm oil bunches + 50% cow dung and to a worst trend of 19.04 in the treatment of 60% empty palm oil bunches + 40% cow dung. Compost is considered mature when it is blackish brown in color, soft in texture, and smells of earth; the pH value at the end of the study was most favorable for the treatment of 70% empty palm oil bunches + 30% cow manure, at 6.6; the temperature in the treatment of 100% empty palm oil bunches was the lowest during the composting process, at 29.00.Keywords: Oil palm empty fruit bunches, cow dung, C/N ratio, activator
Potensi Pengembangan Ternak Sapi Potong Berbasis Ketersediaan Hijauan Pakan Di Pulau Sulabesi Kabupaten Kepulauan Sula
Authors: Norau Irfandi , Yusnaini Yusnaini , Hoda Abdurahman
Published: August 2023

Beef cattle have good prospects to be developed in Indonesia. Forage providing has potential to support the maintenance of beef cattle. This study aims to (1) study the characteristics of beef cattle breeders in Sulabesi island (2) identify and analyze the potential of beef cattle development and beef cattle development strategies. (3) analyze the condition of strategic areas, natural resources, and beef cattle rearing systems for the development of beef cattle, and (4) analyze opportunities, constraints, supporting factors and challenges in order to formulate a development strategy based on internal factors and external factors that can affect the development of beef cattle. This research was conducted on Sulabesi Island from October to December 2022. The characteristics of beef cattle breeders were analyzed by using descriptive statistics. The state of the region that is a sector basis non basis was analyzed by using LQ (Location Quation). Beef cattle development potential was analyzed by using KPPTR and SWOT analysis. The results shows that the farmers in the location were of productive age and had a good education. The types of forages found are very diverse. West Sulabesi, Central Sulabesi and South Sulabesi sub-districts are potential beef cattle bases with LQ values of 2.19, 1.96 and 1.38. There are two subdistricts with very good livestock capacity, namely Sanana District with 45,924 ST and North Sanana District with 32,543 ST. The score of the IFE matrix is 1.10 and the EFE is 1.11 where these two points are in quadrant 1 of the SWOT matrix. In determining the strategy, there are 3 alternative S-O strategies, 4 alternative W-O, 3 S-T and 2 W-T strategies.Key words: Forage, breeder, Sulabesi Island, Beef Cattle, LQ, KPPTR, SWOT.
Analisis Break Even Point Usahatani Pengolahan Kopra di Kecamatan Tidore Utara, Kota Tidore Kepulauan
Authors: Kaddas Fatmawati , Ibrahim Karmila , Basri Iriani
Published: August 2023

This study aims to determine how much income and feasibility of copra processing business in North Tidore District, Tidore Islands City. The research was conducted on copra processing farmers with a sample determination in North Tidore District using simple random sampling with a total of 64 respondents. The results showed that copra processing costs obtained an average value of Rp.2,065,274/year, consisting of fixed costs of Rp.498,967/year and variable costs of Rp.1,566,307/year. The average income is IDR 9,003,500/year and profits are IDR 6,938,226/year. Analysis of the feasibility of the copra processing business in North Tidore District, Tidore Islands City, for the average respondent, the R/C ratio value was 4.3, which means efficiency because for every Rp. 1 spent, a benefit of Rp. 4,3. The results of the BEP Break Even Point price obtained a value of Rp.1,261, a production BEP obtained a value of 109.8 kg and BEP revenue obtained a value of Rp.604,051.74 This means that the copra business is feasible to cultivate.Keywords: Processing, Copra, Break Even Point
DINAMIKA OVARIUM SAPI CROSSBREED PROLONGED OESTRUS DITERAPI DENGAN HUMAN CHORIONIC GONADOTROPIN (hCG)
Authors: Kurniadi Nisfu Bayu , Tumbelaka Ligaya I.T.A , Priyanto Langgeng , Amrozi Amrozi , Putranti Oktora Dwi
Published: August 2023

Penelitian ini bertujuan untuk mengtahui evektifitas pengobatan prolonged oestrus dengan menggunakan human chorionic gonadotropin (hCG) berdasarkan pengamatan dinamika ovarium dengan metode ultrasonografi (USG). Empat ekor sapi induk Simmental Crossbreed dilakukan pengamatan pada siklus estrus pertama dan siklus estrus selanjutnya. Siklus estrus pertama (n=4) natural tanpa hCG (-hCG), dan siklus estrus kedua (n=4) diterapi dengan hCG (+hCG) secara intravena. Hasil pengamatan terhadap sapi prolonged oestrus memperlihatkan 3 gelombang folikel dalam satu siklus estrus. Hasil analisis statistik menunjukan perbedaan nyata (P0,05) terhadap waktu ovulasi. Rataan waktu ovulasi pada sapi (-hCG) dan dengan (+hCG) masing- masing adalah 54Â±12 jam dan 24Â±0 jam. Tetapi tidak memperlihatkan perbedaan yang nyata (P0,05) terhadap ukuran folikel ovulasi. Rataan ukuran folikel preovulasi pada sapi (-hCG) dan dengan (+hCG) masing- masing adalah 1.57Â±0.09 jam dan 24Â±0 jam. Dapat disimpulkan bahwa penyuntikan hCG dapat mempercepat waktu ovulasi namun tidak mempengaruhi ukuran folikel preovulasi.Kata Kunci: Dinamika Ovarium, hCG, Waktu Ovulasi, Simmental Crossbreed.
Dispositivo para identificar Contribuciones de la Naturaleza a las Personas y realizar una valoración integral
Authors: Alonso Roldán Virginia , Rius Pía , Alvarez Manriquez Lorena
Published: August 2023

Está bien establecido en la literatura que la identificación de Contribuciones de la Naturaleza a las Personas (CNP) y su valoración debe basarse en un proceso participativo. Sin embargo, hay pocos dispositivos disponibles para conducir estos procesos participativos y el concepto de contribuciones de la naturaleza a las personas presenta desafíos para su comprensión y aplicación para muchos actores de las esferas sociales y/o gubernamentales. Aquí se presenta una propuesta metodológica y el diseño de un dispositivo para la identificación, valoración y mapeo de CNP que fue aplicado con éxito en cuatro unidades territoriales en el centro-este de Patagonia, Argentina.
A RURAL-URBAN COMPARISON OF PERFORMANCE-BASED PRIMARY HEALTH CARE SERVICES IN ERZURUM
Authors: KARAŞAHİN Emine Füsun , TURFAN Orhan , İBİŞOĞLU Birgül , KARASAHİN Omer , BEDİR Gürsel
Published: August 2023

Objective: The aim of this study was to examine rural-urban differences in performance-based service data and evaluate the reasons family physicians are unable to provide service by performance exception forms. Methods: We retrospectively evaluated 4187 performance exception forms sent to the provincial health directorate by family physicians between 2019 and 2021. The preventive health service not provided, the reason specified by the family physician, the year, and whether the setting was rural or urban were noted. Results: Between 2019 and 2021, there were 2553 applications from urban areas and 1634 applications from rural areas. There were significantly fewer applications from rural areas. During this period, disruptions in immunization services were most frequent (61.1%), with a significantly greater frequency in urban (65.5%) than rural (54.3%) settings. Nearly one-third of service disruptions were attributed to migration out of the family physician’s service area. The most common reason reported for immunization service disruption was vaccine refusal (47.6%). Conclusion: Vaccine refusal and migration were identified as the main barriers to the provision of preventive health services. Although the global struggle against vaccine rejection continues, national legislative changes should be implemented to prevent a simple factor such as migration from interrupting health services in our country.
TÜRKİYE’NİN BİYOAKTİF TOHUMLU BİTKİLERİ VERİTABANI
Authors: ÖZDEMİR KORKMAZ Sedef , EGE Mehmet Ali , ÖZTÜRK Bintuğ , ELGİN CEBE Gözde
Published: August 2023

Amaç: Bugüne kadar, tohumlu bitkilerin kimyasal içerikleri ve biyoaktiviteleri üzerine pek çok çalışma yapılmış olup, halen de yapılmaya devam edilmektedir. Ancak bu çalışmalar, farklı erişim kaynaklarında dağınık halde bulunmaktadır ve bu sebeple bilgiye erişim geç ya da eksik olabilmektedir. Bu nedenle bu çalışmada, Türkiye Florası tohumlu bitkileri üzerinde gerçekleştirilen biyoaktivite araştırmalarını kapsayan uzaktan erişilebilir, Türkçe ve İngilizce bir veritabanı oluşturularak bilgilerin sistematik olarak depolanması amaçlanmıştır.
Gereç ve Yöntem: Çalışmanın ilk aşamasında Türkiye Florası tohumlu bitkileri üzerinde yapılmış ve 1928-2018 yılları arasında yayınlanmış biyoaktivite araştırmalarına ulaşılarak, bunlar incelenmiştir ve bir bibliyografya hazırlanmıştır. Çalışmanın ikinci aşamasında ise biyoaktivite çalışmalarının içeriğinde yer alan bilgilerin aktarılabilmesi için web tabanlı veritabanı yönetim sistemi geliştirilerek elde edilen literatürün ve içeriklerinin veritabanına kaydı yapılmıştır. Son olarak da veritabanına kaydedilen içeriklerin analizleri gerçekleştirilmiştir.
Sonuç ve Tartışma: Yapılan taramalar sonucunda 1307 literatür bibliyografyaya dahil edilirken, bunların 1088’inin veritabanına kaydı uygun bulunmuş ve toplam 49.486 satır veri girişi yapılmıştır. Veriler detaylı incelendiğinde, 107 familyaya ait 430 cins ve 1594 taksonun biyoaktivite çalışmalarının kayıtlı olduğu görülmüştür. En çok taksonun yer aldığı familyalar ise Lamiaceae (307 takson), Asteraceae (271 takson) ve Fabaceae (125 takson) olarak belirlenmiştir. Veritabanına, 115 farklı aktivitenin kaydı yapılmıştır. En fazla sayıda taksonun; antimikrobiyal aktivite (962 takson), antioksidan aktivite (950 takson), sitotoksik aktivite (220 takson), antienflamatuar aktivite (160 takson) ve analjezik-antinosiseptif aktivite (113 takson) açısından araştırıldığı görülmektedir. En fazla biyoaktivite çalışmalarıının yapıldığı türler ise Urtica dioica (18 aktivite), Hypericum perforatum (17 aktivite) ve Cistus laurifolius (16 aktivite) olarak tespit edilmiştir. Lokalite kayıtları incelendiğinde en fazla taksonun İç Anadolu Bölgesinden, en az taksonun ise Güneydoğu Anadolu Bölgesinden temin edildiği saptanmıştır.
Prognostic role of computed tomography analysis using deep learning algorithm in patients with chronic hepatitis B viral infection
Authors: Yoo Jeongin , Cho Heejin , Lee Dong Ho , Cho Eun Ju , Joo Ijin , Jeon Sun Kyung
Published: August 2023

Background/Aims: The prediction of clinical outcomes in patients with chronic hepatitis B (CHB) is paramount for effective management. This study aimed to evaluate the prognostic value of computed tomography (CT) analysis using deep learning algorithms in patients with CHB. Methods: This retrospective study included 2,169 patients with CHB without hepatic decompensation who underwent contrast-enhanced abdominal CT for hepatocellular carcinoma (HCC) surveillance between January 2005 and June 2016. Liver and spleen volumes and body composition measurements including subcutaneous adipose tissue (SAT), visceral adipose tissue (VAT), and skeletal muscle indices were acquired from CT images using deep learning-based fully automated organ segmentation algorithms. We assessed the significant predictors of HCC, hepatic decompensation, diabetes mellitus (DM), and overall survival (OS) using Cox proportional hazard analyses. Results: During a median follow-up period of 103.0 months, HCC (n=134, 6.2%), hepatic decompensation (n=103, 4.7%), DM (n=432, 19.9%), and death (n=120, 5.5%) occurred. According to the multivariate analysis, standardized spleen volume significantly predicted HCC development (hazard ratio [HR]=1.01, P=0.025), along with age, sex, albumin and platelet count. Standardized spleen volume (HR=1.01, P<0.001) and VAT index (HR=0.98, P=0.004) were significantly associated with hepatic decompensation along with age and albumin. Furthermore, VAT index (HR=1.01, P=0.001) and standardized spleen volume (HR=1.01, P=0.001) were significant predictors for DM, along with sex, age, and albumin. SAT index (HR=0.99, P=0.004) was significantly associated with OS, along with age, albumin, and MELD. Conclusions: Deep learning-based automatically measured spleen volume, VAT, and SAT indices may provide various prognostic information in patients with CHB.
Current evidence and the potential role of proton beam therapy for hepatocellular carcinoma
Authors: Lee Sung Uk , Kim Tae Hyun
Published: August 2023

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death, and external beam radiation therapy has emerged as a promising approach for managing HCC. Proton beam therapy (PBT) offers dosimetric advantages over X-ray therapy, with superior physical properties known as the Bragg peak. PBT holds promise for reducing hepatotoxicity and allowing safe dose-escalation to the tumor. It has been tried in various clinical conditions and has shown promising local tumor control and survival outcomes. A recent phase III trial demonstrated the non-inferiority of PBT in local tumor control compared to current standard radiofrequency ablation in early-stage HCC. PBT also tended to show more favorable outcomes compared to transarterial chemoembolization in the intermediate stage, and has proven effective in-field disease control and safe toxicity profiles in advanced HCC. In this review, we discuss the rationale, clinical studies, optimal indication, and future directions of PBT in HCC treatment.
Abundance and active patch selection modulate reproductive connectivity and fitness of pea crabs living on sand dollars
Authors: Souza JA , Flores AAV
Published: August 2023

Connectivity is paramount for population stability, but the mechanisms underlying the distribution of populated patches and how they affect reproductive connectivity and individual fitness remain elusive. Here, we mapped the distribution of sand dollars Encope emarginata as habitat patches for obligate-commensal pea crabs Dissodactylus crinitichelis, at several sites in Brazil. At occupied patches, we assessed whole-crab population structure and the fitness of ovigerous females. By doing so, we obtained population snapshots under varying environmental conditions that portrayed the natural variation of connectivity and fitness in the region. While sand dollar supply did not limit the size of crab populations, overall crab abundance limited reproductive connectivity and the potential for offspring production. However, except for cases where connectivity was extremely low and high, active crab aggregations enhanced reproductive potential despite the overall random distribution of sand dollars. Crab interactions within hosts, likely controlled by larger females, added to reproductive connectivity by increasing the frequency of mating pairs. Differently from the population-level case, effects of crab abundance on individual fitness were dual and only detectable when abundance was lowest (positive) or highest (negative), so that fitness remained high at intermediate crab abundance, decreasing when it became either too low (e.g. Allee effects) or too high (e.g. energetic costs of intraspecific competition).
Beyond Misinformation: The Misrepresentation and Misappropriation of Research
Authors: Wasson Winn
Published: August 2023

The contemporary information landscape has produced numerous incidents of researchers having their research misunderstood, misrepresented, or misappropriated—or worse, being subjected to intimidation and harassment—by individuals or groups who seek to cherry-pick evidence in support of ideological agendas or who wish to suppress evidence that counters those same agendas. To help prepare current and future researchers for the possibility that their research might be misrepresented, misappropriated, or politicized in other ways by ideologically motivated individuals or groups, Syracuse University Libraries offers a workshop that covers ways to prepare for and respond to the misrepresentation and misappropriation of their research. The workshop offers participants strategies and tools for researchers to stay current on scholarly and popular communication about their research and field of research; suggestions on venues for preparing and testing responses for potential incidents in which their research is misrepresented or misappropriated; and tactics for handling incidents should they arise.
Neuroimaging based biotypes for precision diagnosis and prognosis in cancer-related cognitive impairment
Authors: Kesler Shelli R. , Henneghan Ashley M. , Prinsloo Sarah , Palesh Oxana , Wintermark Max
Published: August 2023

Cancer related cognitive impairment (CRCI) is commonly associated with cancer and its treatments, yet the present binary diagnostic approach fails to capture the full spectrum of this syndrome. Cognitive function is highly complex and exists on a continuum that is poorly characterized by dichotomous categories. Advanced statistical methodologies applied to symptom assessments have demonstrated that there are multiple subclasses of CRCI. However, studies suggest that relying on symptom assessments alone may fail to account for significant differences in the neural mechanisms that underlie a specific cognitive phenotype. Treatment plans that address the specific physiologic mechanisms involved in an individual patient’s condition is the heart of precision medicine. In this narrative review, we discuss how biotyping, a precision medicine framework being utilized in other mental disorders, could be applied to CRCI. Specifically, we discuss how neuroimaging can be used to determine biotypes of CRCI, which allow for increased precision in prediction and diagnosis of CRCI via biologic mechanistic data. Biotypes may also provide more precise clinical endpoints for intervention trials. Biotyping could be made more feasible with proxy imaging technologies or liquid biomarkers. Large cross-sectional phenotyping studies are needed in addition to evaluation of longitudinal trajectories, and data sharing/pooling is highly feasible with currently available digital infrastructures.
Efficacy of Wharton Jelly Mesenchymal Stromal Cells infusions in moderate to severe SARS-Cov-2 related acute respiratory distress syndrome: a phase 2a double-blind randomized controlled trial
Authors: Pochon Cécile , Laroye Caroline , Kimmoun Antoine , Reppel Loic , Dhuyser Adéle , Rousseau Hélène , Gauthier Mélanie , Petitpain Nadine , Chabot Jean-François , Valentin Simon , de Carvalho Bittencourt Marcelo , Peres Michael , Aarnink Alice , Decot Véronique , Bensoussan Danièle , Gibot Sébastien
Published: August 2023

Background

The COVID-19 pandemic caused a wave of acute respiratory distress syndrome (ARDS) with a high in-hospital mortality, especially in patients requiring invasive mechanical ventilation. Wharton Jelly-derived Mesenchymal Stromal Cells (WJ-MSCs) may counteract the pulmonary damage induced by the SARS-CoV-2 infection through pro-angiogenic effects, lung epithelial cell protection, and immunomodulation.

Methods

In this randomized, double-blind, placebo-controlled phase 2a trial, adult patients receiving invasive mechanical ventilation for SARS-CoV-2 induced moderate or severe ARDS were assigned to receive 1 intravenous infusion of 1 × 106 WJ-MSCs/kg or placebo within 48 h of invasive ventilation followed by 2 infusions of 0.5 × 106 WJ-MSCs/kg or placebo over 5 days. The primary endpoint was the percentage of patients with a PaO2/FiO2 > 200 on day 10.

Results

Thirty patients were included from November 2020 to May 2021, 15 in the WJ-MSC group and 15 in the placebo group. We did not find any significant difference in the PaO2/FiO2 ratio at day 10, with 18 and 15% of WJ-MSCs and placebo-treated patients reaching a ratio >200, respectively. Survival did not differ in the 2 groups with a 20% mortality rate at day 90. While we observed a higher number of ventilation-free days at 28 days in the WJ-MSC arm, this difference was not statistically significant (median of 11 (0–22) vs. 0 (0–18), p = 0.2). The infusions were well tolerated, with a low incidence of anti-HLA alloimmunization after 90 days.

Conclusion

While treatment with WJ-MSCs appeared safe and feasible in patients with SARS-CoV2 moderate or severe ARDS in this phase 2a trial, the treatment was not associated with an increased percentage of patients with P/F > 200 at 10d, nor did 90 day mortality improve in the treated group.

Clinical trial registration

https://beta.clinicaltrials.gov/study/NCT04625738, identifier NCT04625738.
Conventional clock drawing tests have low to moderate reliability and validity for detecting subtle cognitive impairments in community-dwelling older adults
Authors: Kehl-Floberg Kristen E. , Marks Timothy S. , Edwards Dorothy F. , Giles Gordon M.
Published: August 2023

Background

Early identification of subtle cognitive decline in community-dwelling older adults is critical, as mild cognitive impairment contributes to disability and can be a precursor to dementia. The clock drawing test (CDT) is a widely adopted cognitive screening measure for dementia, however, the reliability and validity of paper-and-pencil CDT scoring scales for mild cognitive impairment in community samples of older adults is less well established. We examined the reliability, sensitivity and specificity, and construct validity of two free-drawn clock drawing test scales–the Rouleau System and the Clock Drawing Interpretation Scale (CDIS)–for subtle cognitive decline in community-dwelling older adults.

Methods

We analyzed Rouleau and CDIS scores of 310 community-dwelling older adults who had MoCA scores of 20 or above. For each scale we computed Cronbach’s alpha, receiver operating characteristic curves (ROC) for sensitivity and specificity using the MoCA as the index measure, and item response theory models for difficulty level.

Results

Our sample was 75% female and 85% Caucasian with a mean education of 16 years. The Rouleau scale had excellent interrater reliability (94%), poor internal consistency [0.37 (0.48)], low sensitivity (0.59) and moderate specificity (0.71) at a score of 9. The CDIS scale had good interrater reliability (88%), moderate internal consistency [0.66 (0.09)], moderate sensitivity (0.78) and low specificity (0.45) at a score of 19. In the item response models, both scales’ total scores gave the most information at lower cognitive levels.

Conclusion

In our community-dwelling sample, the CDIS’s psychometric properties were better in most respects than the Rouleau for use as a screening instrument. Both scales provide valuable information to clinicians screening older adults for cognitive change, but should be interpreted in the setting of a global cognitive battery and not as stand-alone instruments.
Elongating, entwining, and dragging: mechanism for adaptive locomotion of tubificine worm blobs in a confined environment
Authors: Mikami Taishi , Wakita Daiki , Kobayashi Ryo , Ishiguro Akio , Kano Takeshi
Published: August 2023

Worms often aggregate through physical connections and exhibit remarkable functions such as efficient migration, survival under environmental changes, and defense against predators. In particular, entangled blobs demonstrate versatile behaviors for their survival; they form spherical blobs and migrate collectively by flexibly changing their shape in response to the environment. In contrast to previous studies on the collective behavior of worm blobs that focused on locomotion in a flat environment, we investigated the mechanisms underlying their adaptive motion in confined environments, focusing on tubificine worm collectives. We first performed several behavioral experiments to observe the aggregation process, collective response to aversive stimuli, the motion of a few worms, and blob motion in confined spaces with and without pegs. We found the blob deformed and passed through a narrow passage using environmental heterogeneities. Based on these behavioral findings, we constructed a simple two-dimensional agent-based model wherein the flexible body of a worm was described as a cross-shaped agent that could deform, rotate, and translate. The simulations demonstrated that the behavioral findings were well-reproduced. Our findings aid in understanding how physical interactions contribute to generating adaptive collective behaviors in real-world environments as well as in designing novel swarm robotic systems consisting of soft agents.
Navigating bioactivity space in anti-tubercular drug discovery through the deployment of advanced machine learning models and cheminformatics tools: a molecular modeling based retrospective study
Authors: Bhowmik Ratul , Kant Ravi , Manaithiya Ajay , Saluja Daman , Vyas Bharti , Nath Ranajit , Qureshi Kamal A. , Parkkila Seppo , Aspatwar Ashok
Published: August 2023

Mycobacterium tuberculosis is the bacterial strain that causes tuberculosis (TB). However, multidrug-resistant and extensively drug-resistant tuberculosis are significant obstacles to effective treatment. As a result, novel therapies against various strains of M. tuberculosis have been developed. Drug development is a lengthy procedure that includes identifying target protein and isolation, preclinical testing of the drug, and various phases of a clinical trial, etc., can take decades for a molecule to reach the market. Computational approaches such as QSAR, molecular docking techniques, and pharmacophore modeling have aided drug development. In this review article, we have discussed the various techniques in tuberculosis drug discovery by briefly introducing them and their importance. Also, the different databases, methods, approaches, and software used in conducting QSAR, pharmacophore modeling, and molecular docking have been discussed. The other targets targeted by these techniques in tuberculosis drug discovery have also been discussed, with important molecules discovered using these computational approaches. This review article also presents the list of drugs in a clinical trial for tuberculosis found drugs. Finally, we concluded with the challenges and future perspectives of these techniques in drug discovery.