bluuebunny/crossref_metadata_2025 huggingface dataset:
Ultrafine Grinded and Silane Grafted Iron Ore Tailings as Reinforcing Filler of Styrene Butadiene Rubber
Authors: Liu Qian , Tang Qingguo , Zhao Weiwei , Su Zhiyuan , Liang Cong , Duan Xinhui , Liang Jinsheng
Published: February 2022

In order to realize the high value-added resource utilization of solid waste and reduce the cost of rubber manufacturing, iron ore tailings (IOTs) were used as raw material to prepare a reinforcing filler of rubber through ultrafine grinding and surface organic modification techniques. We studied the effects of ball mill grinding conditions on the particle size and distribution of grinded iron ore tailings (G-IOTs). The effects of bis-(triethoxy-silyl-propyl)-tetrasulfide (Si69)-modified G-IOT (Si69-G-IOT) loading levels on the cure characteristics, static mechanical and dynamic mechanical properties of the styrene butadiene rubber (SBR) composites were also explored in this paper. The grinding and modification mechanism of IOTs and the combination of filler and SBR matrix were explored by grinding simulation of population balance model, X-ray diffraction analysis, Fourier transform infrared spectroscopy and scanning electron microscopy. The results showed that when grinding IOTs at 2000 r/min for 150 min, the particle size distribution of the resulting G-IOTs was the narrowest, with a D90 value of 4.42 μm. The tensile strength and elongation at break of SBR filled with 120 phr Si69-G-IOT were 14.97 MPa and 596.36%, respectively.
The Stability of Spiral-Grooved Air Journal Bearings in Ultrahigh Speeds
Authors: Song Laiyun , Yuan Guoqin , Zhang Hongwen , Ding Yalin , Cheng Kai
Published: February 2022

The spiral-grooved structure has been proposed for promoting the load capacity and stiffness of hybrid air journal bearings. In this paper, the dynamic characteristics of spiral-grooved hybrid bearings are first calculated. The stability criteria of the bearings are proposed and analyzed with different groove structure parameters using frequency domain analysis. It is found that the length of the spiral-groove has significant influence on the stability of the spindle system. Finally, the critical speed of the spiral-grooved hybrid bearing and rotor system is analyzed, and an experiment is carried out to validate the proposed model, finding that groove structure can promote the stability of the air bearing systems.
Experimental Research on Mechanical Properties and Compression Constitutive Relationship of PVA Fiber-Reinforced Coral Concrete
Authors: Rao Lan , Wang Ling , Zheng Yun
Published: February 2022

In this paper, the mechanical properties of coral concrete with different strength and different polyvinyl alcohol (PVA) fiber content under compression were experimentally investigated. The results show that adding an appropriate amount of PVA fiber could obtain satisfactory mechanical properties of coral concrete. The stress–strain constitutive relationship of plain and PVA fiber-reinforced coral concrete was investigated by prism uniaxial compression test. The results shown that the incorporation of PVA fiber had a significant effect on limiting the development of concrete internal cracks, and effectively improved the mechanical properties of coral concrete after cracking, especially the toughness. Different constitutive models from previous research were used to describe the axial compressive stress–strain relationship of plain and PVA fiber-reinforced coral concrete, and a piecewise function model was finally selected which is most consistent with the experimental curve and its characteristic points. In addition, determination of critical parameters for the selected constitutive model was proposed, and experimental validations confirmed its accuracy.
Gold Nanorods for Doxorubicin Delivery: Numerical Analysis of Electric Field Enhancement, Optical Properties and Drug Loading/Releasing Efficiency
Authors: Qamar Muhammad , Abbas Ghulam , Afzaal Muhammad , Naz Muhammad Y. , Ghuffar Abdul , Irfan Muhammad , Legutko Stanislaw , Jozwik Jerzy , Zawada-Michalowska Magdalena , Ghanim Abdulnour Ali Jazem , Rahman Saifur , Niazi Usama M. , Jalalah Mohammed , Alkahtani Fahad Salem , Khan Mohammad K. A. , Kosicka Ewelina
Published: February 2022

The optical properties and electric field enhancement of gold nanorods for different cases were investigated in this study. The numerical analysis was carried out to understand the functionality and working of gold nanorods, while the experimental portion of the work was focused on the efficiency of gold nanorods for targeted drug delivery. COMSOL Multiphysics was used for numerical analysis. The theoretical results suggest the use of gold nanorods (AuNRs) for anticancer applications. The resonance peaks for gold nanorods of 10 nm diameter were observed at 560 nm. The resonance peaks shifted towards longer wavelengths with an increase in nanorod size. The resonance peaks showed a shift of 140 nm with a change in nanorod length from 25 to 45 nm. On the experimental side, 22 nm, 35 nm and 47 nm long gold nanorods were produced using the seed-mediated growth method. The surface morphology of the nanorods, as well as their optical characteristics, were characterized. Later, gold nanorods were applied to the targeted delivery of the doxorubicin drug. Gold nanorods showed better efficiency for doxorubicin drug loading time, release time, loading temperature, and release temperature. These results reveal that AuNRs@DA possess good ability to load and deliver the drug directly to the tumorous cells since these cells show high temperature and acidity.
Experimental Research on Manson–Coffin Curves for the Frame Material of an Unconventional Vehicle
Authors: Blatnický Miroslav , Dižo Ján , Sága Milan , Brůna Marek , Vaško Milan
Published: February 2022

The submitted research paper describes the fundamental findings in terms of multiaxial fatigue of the basic material EN AW6063 and its welds for implementation in the frame design of an unconventional vehicle. It also includes a briefly-presented conceptual design of a technical solution for optimizing the functionality of a steering mechanism in a patented unconventional vehicle, designed by the authors to increase the cornering stability of a vehicle–tricycle. The most important part of this article is the description of the ongoing research and the results of multiaxial fatigue (bending–torsion combination) of the structural material for the construction of the vehicle frame. The research in this area is important due to the increased load on the frame during operation caused by the unconventional steering mechanism. The measured and constructed Manson–Coffin curves indicate that the use of material EN AW6063 is possible for this vehicle in terms of multiaxial stress. This also applies to the material affected by the technology in the frame production (TIG welding). A higher fatigue of the basic material was observed at a 90° phase shift. The difference between the 0° and 90° phases practically makes up approximately 10 to 15% of the difference in the cycle numbers with the same deformation amplitude. At the same time, the measured results show that the phase shift between loads will not play such an important role in welded joints of aluminum alloy EN AW6063. When comparing the dependences with a constant deformation amplitude in bending and in torsion, it can be said that the bending stress will react more to even a small change in the deformation amplitude. Bending has been proven to be the more dominant component of the total deformation amplitude in multiaxial tests. In terms of low-cycle multiaxial fatigue (up to 5 × 105 cycles), a higher fatigue of the basic material is found in comparison with the weld. At lower deformation amplitudes, a higher fatigue of the welded material is detected.
Enhanced Electromechanical Response in PVDF-BNBT Composite Nanofibers for Flexible Sensor Applications
Authors: Leung Chung Ming , Chen Xiaoqiu , Wang Tao , Tang Yanxue , Duan Zhihua , Zhao Xiangyong , Zhou Helezi , Wang Feifei
Published: February 2022

Wearable energy harvesters and sensors have recently attracted significant attention with the rapid development of artificial intelligence and the Internet of Things (IoT). Compared to high-output bulk materials, these wearable devices are mainly fabricated by thin-film-based materials that limit their application. Therefore, the enhancement of output voltage and power for these devices has recently become an urgent topic. In this paper, the lead-free bismuth titanate-barium titanate (0.93(Na0.5Bi0.5)TiO3-0.07BaTiO3(BNBT)) nanoparticles and nanofibers were embedded into the PVDF nanofibers. They produced high inorganic electrical voltage coefficients, high electromechanical coupling coefficients, and environmentally friendly properties that enhance the electromechanical performance of pure PVDF nanofibers, and they are all the critical requirements for modern flexible pressure sensors. In detail, PVDF and PVDF-based composites nanofibers were prepared by electrospinning, and different flexible sandwich composite devices were fabricated by the PDMS encapsulation method. As a result, the six-time enhancement maximum output voltage was obtained in a PVDF-BNBT (fiber)-based composite sensor compared to the pure PVDF one. Our results indicate that the output voltage of the pressure sensors has been significantly enhanced, and the development gate is enabled by analyzing the related physical process and influence mechanism.
Bitumen Binders Modified with Sulfur/Organic Copolymers
Authors: Wręczycki Jakub , Demchuk Yuriy , Bieliński Dariusz M. , Bratychak Michael , Gunka Volodymyr , Anyszka Rafał , Gozdek Tomasz
Published: February 2022

With the continuing growth of waste sulfur production from the petroleum industry processes, its utilization for the production of useful, low-cost, and environmentally beneficial materials is of primary interest. Elemental sulfur has a significant and established history in the modification of bitumen binders, while the sulfur-containing high-molecular compounds are limited in this field. Herein, we report a novel possibility to utilize the sulfur/organic copolymers obtained via the inverse vulcanization process as modifiers for bitumen binders. Synthesis and thermal characterization (TGA-DSC) of polysulfides derived from elemental sulfur (S8) and unsaturated organic species (dicyclopentadiene, styrene, and limonene) have been carried out. The performance of modified bitumen binders has been studied by several mechanical measurements (softening point, ductility, penetration at 25 °C, frass breaking point, adhesion to glass and gravel) and compared to the unmodified bitumen from the perspective of normalized requirements concerning polymer-modified bitumen. The interaction of bitumen binder with sulfur/organic modifier has been studied by means of FTIR spectroscopy and DSC measurements. The impact of the modification on the performance properties of bitumen has been demonstrated. The bitumen binders modified with sulfur/organic copolymers are in general less sensitive to higher temperatures (higher softening point up to 7 °C), more resistant to permanent deformations (lower penetration depth), and more resistant to aging processes without intrusive deterioration of parameters at lower temperatures. What is more, the modification resulted in significantly higher adhesion of bitumen binders to both glass (from 25% up to 87%) and gravel surfaces in combination with a lower tendency to form permanent deformations (more elastic behavior of the modified materials).
Rheological Evaluation of Softened Binders Blended with Aged Asphalt Selected with a High-Temperature Mixing Chart
Authors: Ochoa-Ambriz Leonardo , Pérez-Rea María de la Luz , Hernández-Padrón Genoveva , Limón-Covarrubias Pedro , Galaviz-González José Roberto , Avalos-Cueva David
Published: February 2022

Reclaimed asphalt pavements (RAP) provide economic and environmental benefits. In recent decades, their use has increased, but rheological properties are affected by RAP aging, increasing stiffness, cracking, and susceptibility to water. To counteract these effects, rejuvenating agents are used, but they must be properly dosed to design quality mixtures. Therefore, different binders were analyzed, including virgin binder (VBB), binder modified by SBS polymer (MB), AC-RAP, binder softened using a rejuvenating agent, and binders softened with doses (15%, 30%, and 45%) of AC-RAP. The rheological properties were evaluated by dynamic shear rheometry (DSR) and beam-bending rheometry (BBR) tests, while the linear amplitude sweep (LAS) test was used to measure fatigue cracking and the multiple stress creep recovery (MSCR) test was used to measure rutting. A mixing chart was constructed based on a high temperature AC-RAP to satisfy the performance grade (PG 76-22). The results showed that softened binders become flexible, but when AC-RAP is added, they turn stiff and behave better than MB. Moreover, combining a rejuvenating agent and AC-RAP reduces the aging stiffness of RAP, improving its rheological properties without compromising the rutting or cracking resistance.
Mechanical Properties and Durability Performance of Recycled Aggregate Concrete Containing Crumb Rubber
Authors: Ataria Robert B. , Wang Yong C.
Published: February 2022

Despite extensive research studies, recycled aggregates and worn-out tyres of motor vehicles are still not fully reused and are hence disposed of in ways that are damaging to the environment. Several studies have been carried out on recycled aggregate and rubberized concrete, but very limited studies are conducted on rubber recycled aggregate concrete. This study focuses on the workability, mechanical properties and durability performance of concrete made with 100% recycled aggregates and crumb rubber at different replacement level (5%, 10%, 15% and 20%). The first stage of the study covers the effect of incorporating crumb rubber at different concentration on the workability and mechanical properties of recycled aggregate concrete. The results revealed that the workability and mechanical properties of the recycled aggregate concrete can be used for structural applications when 5% of crumb rubber are used to replace recycled aggregates. The 28-days compressive strength of the rubberized recycled aggregate concrete with 5% crumb rubber concentration is reduced by 21.1% and 32.8% when compared to recycled aggregate concrete and control concrete, respectively. The second stage of the study assesses the durability performance of the recycled aggregate concrete with 5% crumb rubber concentration. The 5% crumb rubber content for durability tests was considered because the ultrasonic pulse velocity tests revealed that the quality of the recycled aggregate concrete is questionable if the concentration of crumb rubber particles is beyond 5%. The durability performance using the surface resistivity test also shows that the chloride ion penetration of recycled aggregates concrete with 5% crumb rubber replacement is moderate using air dried curing technique and high using the water bath curing method. Hence the study suggests the use of rubber recycled aggregate concrete for applications were the exposure condition is not extreme.
Hot Deformation Behaviour and Constitutive Equation of Mg-9Gd-4Y-2Zn-0.5Zr Alloy
Authors: Nie Yangjunfeng , Zheng Jie , Han Rui , Jia Leichen , Zhang Zhimin , Xue Yong
Published: February 2022

The thermal deformation behaviour of Mg-9Gd-4Y-2Zn-0.5Zr alloy at temperatures of 360–480 °C, strain rates of 0.001–1 s−1 and a maximum deformation degree of 60% was investigated in uniaxial hot compression experiments on a Gleeble 3800 thermomechanical simulator. A constitutive equation suitable for plastic deformation was constructed from the Arrhenius equation. The experimental results indicate that due to work hardening, the flow stress of the alloy rapidly reached peak stress with increased strain in the initial deformation stage and then began to decrease and stabilize, indicating that the deformation behaviour of the alloy conformed to steady-state rheological characteristics. The average deformation activation energy of this alloy was Q = 223.334 kJ·mol−1. Moreover, a processing map based on material dynamic modelling was established, and the law describing the influence of the machining parameters on deformation was obtained. The experimental results indicate that the effects of deformation temperature, strain rate and strain magnitude on the peak dissipation efficiency factor and instability range were highly significant. With the increase in the strain variable, the flow instability range increased gradually, but the coefficient of the peak power dissipation rate decreased gradually. The optimum deformation temperature and strain rate of this alloy during hot working were 400–480 °C and 0.001–0.01 s−1, respectively.
Study on Solidification and Stabilization of Antimony-Containing Tailings with Metallurgical Slag-Based Binders
Authors: Li Yunyun , Ni Wen , Gao Wei , Zhang Siqi , Fu Pingfeng , Li Yue
Published: February 2022

Blast furnace slag (BFS), steel slag (SS), and flue gas desulfurized gypsum (FGDG) were used to prepare metallurgical slag-based binder (MSB), which was afterwards mixed with high-antimony-containing mine tailings to form green mining fill samples (MBTs) for Sb solidification/stabilization (S/S). Results showed that all MBT samples met the requirement for mining backfills. In particular, the unconfined compressive strength of MBTs increased with the curing time, exceeding that of ordinary Portland cement (OPC). Moreover, MBTs exhibited the better antimony solidifying properties, and their immobilization efficiency could reach 99%, as compared to that of OPC. KSb(OH)6 was used to prepare pure MSB paste for solidifying mechanism analysis. Characteristics of metallurgical slag-based binder (MSB) solidified/stabilized antimony (Sb) were investigated via X-ray diffraction (XRD), field emission scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), Fourier transform infrared spectroscopy (FT-IR), and X-ray photoelectron spectroscopy (XPS). According to the results, the main hydration products of MSB were C-S-H gel and ettringite. Among them, C-S-H gel had an obvious adsorption and physical sealing effect on Sb, and the incorporation of Sb would reduce the degree of C-S-H gel polymerization. Besides, ettringite was found to exert little impact on the solidification and stabilization of Sb. However, due to the complex composition of MSB, it was hard to conclude whether Sb entered the ettringite lattice.
Analysis of Engineering Characteristics and Microscopic Mechanism of Red Mud–Bauxite Tailings Mud Foam Light Soil
Authors: Ou Xiaoduo , Chen Shengjin , Jiang Jie , Qin Jinxi , Tan Zhijie
Published: February 2022

In order to effectively utilize aluminum industrial waste—red mud and bauxite tailings mud—and reduce the adverse impact of waste on the environment and occupation of land resources, a red mud–bauxite tailings mud foam lightweight soil was developed based on the existing research results. Experiments were conducted to investigate the mechanical properties and microscopic characteristics of the developed materials with different proportions of red mud and bauxite tailings mud. Results show that with the increase in red mud content, the wet density and fluidity of the synthetic sample was increased. With 16% red mud content, the water stability coefficient of the synthetic sample reached its maximum of 0.826, as well as the unconfined compressive strength (UCS) of the sample cured for 28 d (1.056 MPa). SEM images reveal that some wastes of the sample without red mud were agglomerated, the peripheral hydration products were less wrapped, and when the amount of red mud was 16%, the hydration products tightly wrapped the waste particles and increased the structural compactness. The final concentration of alkali leaching of samples increased with the addition of red mud. The maximum concentration of alkali leaching was 384 mg/L for the group with the addition of red mud of 16%. Based on the obtained mechanical strength and alkali release analysis, the sample B24R16 was selected as the optimum among all tested groups. This study explored a way to reuse aluminum industrial waste, and the results are expected to be applied to roadbed and mining filling.
Sustainable Use of Sludge from Industrial Park Wastewater Treatment Plants in Manufacturing Lightweight Aggregates
Authors: Tang Chao-Wei , Cheng Chiu-Kuei
Published: February 2022

The aim of this study was to investigate the development of a process for manufacturing lightweight aggregates (LWAs) by incorporating sludge from wastewater treatment plants in industrial parks with reservoir sediments. The research was divided into two stages: laboratory-scale firing and large-scale firing. In the laboratory-scale stage, a high-temperature furnace was used for trial firing. In the large-scale stage, a commercial rotary kiln was used for trial firing for mass production. The test results showed that the water absorption, dry loose bulk density, and crushing strength of the sintered LWAs were 14.2–26.9%, 634–753 kg/m3, and 1.29–2.90 MPa, respectively. Moreover, the water absorption of the sintered LWAs increased as the percentage of added sludge increased. In addition, the dry loose bulk density of the sintered LWAs gradually decreased as the percentage of added sludge increased. Moreover, the results of the heavy metal toxicity characteristic leaching procedure (TCLP) dissolution test for the LWAs produced by blending 30–50% sludge were all lower than the standard value required by the Taiwan Environmental Protection Agency for general industrial waste. The strength grade of the sintered LWAs was 20 MPa. From this point of view, the sintered LWAs that were studied under the test conditions could be used as aggregates for lightweight concrete and would allow it to have a reasonable strength of greater than 20 MPa.
Designing of the Electromechanical Drive for Automated Hot Plate Welder Using Load Optimization with Genetic Algorithm
Authors: Wałęsa Krzysztof , Talaśka Krzysztof , Wilczyński Dominik
Published: February 2022

Drive and conveyor belts are widely used in the mining and processing industry. One of the types often used is the belt with a cross-section and a diameter of several millimeters, made of weldable thermoplastic elastomer. Their production process requires the joining of the ends to obtain a closed loop. This operation is often performed by butt welding using the hot plate method. Taking into account the industrial requirements, the authors made an effort to design the automated welding machine for this type of belt. The work that had been conducted was finished with the implementation of the device for serial belt production. One of the stages of the design process of the welding machine consisted of developing a solution for the electromechanical drive system. The paper presents a design and the selection of the key components of the drive system, in particular, the electrical executive elements. Firstly, on the basis of the functional requirements of individual working mechanisms, the kinematic structure of the drives was developed, and the influence of the workload on power consumption was described. Then, using known technological parameters, experimental research of the plasticization operation was performed. On the basis of the results obtained, a mathematical model of the correlation between the plasticization force and technological parameters was derived. Using the derived model, the optimization of the technological parameters was made by using a genetic algorithm. The work led to the choice of an effective electric motor, which is the main component of the designed drive system.
Evaluation of Acoustic Waves in Acousto-Optical Devices by Ultrasonic Imaging
Authors: Titov Sergey A. , Machikhin Alexander S. , Pozhar Vitold Ed.
Published: February 2022

The structure of the acoustic field defines the key parameters of acousto-optical (AO) devices. To confirm their compliance with the expected values in the presence of multiple real factors, AO crystalline cells require accurate experimental investigation of the acoustic field after being totally assembled. For this purpose, we propose to detect and quantify all the acoustic waves propagating in AO cells using an impulse acoustic microscopy technique. To validate this approach, we have analyzed both theoretically and experimentally the modes, amplitudes, propagation trajectories, and other features of the ultrasonic waves generated inside an AO modulator made of fused quartz. Good correspondence between theoretical and experimental data confirms the effectiveness of the proposed technique.
Atomic Layer Deposition of Ultrathin La2O3/Al2O3 Nanolaminates on MoS2 with Ultraviolet Ozone Treatment
Authors: Fan Jibin , Shi Yimeng , Liu Hongxia , Wang Shulong , Luan Lijun , Duan Li , Zhang Yan , Wei Xing
Published: February 2022

Due to the chemically inert surface of MoS2, uniform deposition of ultrathin high-κ dielectric using atomic layer deposition (ALD) is difficult. However, this is crucial for the fabrication of field-effect transistors (FETs). In this work, the atomic layer deposition growth of sub-5 nm La2O3/Al2O3 nanolaminates on MoS2 using different oxidants (H2O and O3) was investigated. To improve the deposition, the effects of ultraviolet ozone treatment on MoS2 surface are also evaluated. It is found that the physical properties and electrical characteristics of La2O3/Al2O3 nanolaminates change greatly for different oxidants and treatment processes. These changes are found to be associated with the residual of metal carbide caused by the insufficient interface reactions. Ultraviolet ozone pretreatment can substantially improve the initial growth of sub-5 nm H2O-based or O3-based La2O3/Al2O3 nanolaminates, resulting in a reduction of residual metal carbide. All results indicate that O3-based La2O3/Al2O3 nanolaminates on MoS2 with ultraviolet ozone treatment yielded good electrical performance with low leakage current and no leakage dot, revealing a straightforward approach for realizing sub-5 nm uniform La2O3/Al2O3 nanolaminates on MoS2.
Contribution of Dislocations in SiC Seed Crystals on the Melt-Back Process in SiC Solution Growth
Authors: Kawanishi Sakiko , Shibata Hiroyuki , Yoshikawa Takeshi
Published: February 2022

The melt-back process has a significant effect on the quality of solution-grown SiC crystals. However, the phenomena surrounding the SiC dissolution into the molten alloy during the melt-back process have not been clarified. In this study, the behavior of 4H-SiC dissolution into molten alloy was investigated by using high-temperature in situ observation and subsequent KOH etching, and the effects of different doping conditions and crystal polarity were studied. Local dissolutions with hexagonal pyramid-shape originating from threading screw dislocation (TSD) were observed on the C face of n-type SiC with light nitrogen doping. Our analysis of their behavior revealed that the process was governed by the spiral dissolution. In addition to the dissolution at TSD, local dissolutions at threading-edge dislocations were observed on the Si face of the same crystal. The shape of the local dissolution at the dislocation was significantly affected by the doping conditions and the polarity of the SiC crystal. This local dissolution may occur during the melt-back process, suggesting that it is important to promote the dissolution while maintaining a smooth interface through the selection of the seed crystal and by keeping the degree of interface undersaturation small.
Experimental and Numerical Study on Friction and Wear Performance of Hot Extrusion Die Materials
Authors: Zhao Leilei , Zhou Kecheng , Tang Ding , Wang Huamiao , Li Dayong , Peng Yinghong
Published: February 2022

For the aluminium alloys produced by the hot extrusion process, the profile is shaped according to the bearing at the exit of the extrusion die. The tribological process has significant effects on the die service life, profile dimensional tolerances, and profile surface finish. Recently, new technologies have been introduced to the hot extrusion die, such as cemented carbide insert die and surface coating. However, under hot extrusion working conditions, quantitative studies on their friction and wear performances are lacking. In this work, the friction and wear performances of three typical extrusion die materials, traditional hot tool steel (H13), cemented carbide (YG8), and chemical vapour deposition (CVD) coating, were studied. Macro and nano hardness tests, Pin-on-disk friction and wear tests, optical profiler and SEM observations, and experiments and simulations of hot extrusion were conducted. The results show that the coefficients of friction of CVD coatings and H13 hot work tool steel specimens were smaller under the hot extrusion condition than at room temperature. The wear mechanisms of H13, YG8, and CVD coatings at 500 °C are adhesion, abrasive, and fatigue, respectively. Moreover, the tribology results were validated by the extrusion experiments and the finite element analysis of hot extrusion. The conclusion of this manuscript is useful not only for the numerical simulation of the hot extrusion process but also for the surface finishing of the extrusion profile.
The Effect of Y3+ Addition on Morphology, Structure, and Electrical Properties of Yttria-Stabilized Tetragonal Zirconia Dental Materials
Authors: Jakovac Marko , Klaser Teodoro , Bafti Arijeta , Skoko Željko , Pavić Luka , Žic Mark
Published: February 2022

Zirconia (ZrO2), a widely known material with an extensive range of applications, is especially suitable for dental applications. This kind of dental material is produced in the form of blocks or discs (mostly discs—depending on CAD/CAM machines) by cold isostatic pressing (CIP). Such discs are subsequently milled by CAM/CAD technology into a desirable form. Due to the application of CIP, the resulting discs consist of different yttria-stabilized tetragonal zirconia polycrystal (Y-TZP) powders, additives and pigments. The diverse composition of the discs (e.g., different Y3+ content) governs material properties, such as hardness, toughness and translucence. The aim of this work was to investigate the impact of Y3+ addition on the grains and grain boundaries, on the ZrO2 phases lattice parameter values and on the electrical equivalent circuit parameters of the prepared Y-TZP samples. The disc-shaped samples were prepared by using CAM/CAD technology. It was observed that the grain size and the grain density were increased by Y3+ addition. The sample with the lowest Y3+ content was characterized by the highest portion of the tetragonal phase, whilst the disc with the highest Y3+ addition consisted mainly of the cubic phase. It was also observed that at the higher Y3+ ion concentrations, these ions mainly incorporated the tetragonal phase. Furthermore, conductivity investigations showed that the resistivity of the grains in the samples with the higher Y3+ concentrations was decreased as these ions were mainly trapped in the grain boundary. On the other hand, the Y3+ trapping increased the capacitance of the grain boundary.
Mathematical Modeling the Time-Delay Interactions between Tumor Viruses and the Immune System with the Effects of Chemotherapy and Autoimmune Diseases
Authors: Pham Hoang
Published: February 2022

The immune system is the body’s defense against pathogens, which are complex living organisms found in many parts in the body including organs, tissues, cells, molecules, and proteins. When the immune system works properly, it can recognize and kill the abnormal cells and the infected cells. Otherwise, it can attack the body’s healthy cells even if there is no invader. Many researchers have developed immunotherapy (or cancer vaccines) and have used chemotherapy for cancer treatment that can kill fast-growing cancer cells or at least slow down tumor growth. However, chemotherapy drugs travel throughout the body and tend to kill both healthy cells and cancer cells. In this study, we consider the fact that chemotherapy can kill tumor cells and that the loss of the immune cells may at the same time stir up cancer growth. We present a dynamic time-delay tumor-immune model with the effects of chemotherapy drugs and autoimmune disease. The modeling results can be used to determine the progression of tumor cells in the human body with the effect of chemotherapy, autoimmune diseases, and time delays based on partial differential equations. It can also be used to predict when the tumor viruses’ free state can be reached as time progresses, as well as the state of the body’s healthy cells as time progresses. We also present a few numerical cases that illustrate that the model can be used to monitor the effects of chemotherapy drug treatment and the growth rate of tumor virus-infected cells and the autoimmune disease.
Biochemical Properties of a New Polysaccharide Lyase Family 25 Ulvan Lyase TsUly25B from Marine Bacterium Thalassomonas sp. LD5
Authors: Wang Danni , Li Yujiao , Han Lu , Yin Chengying , Fu Yongqing , Zhang Qi , Zhao Xia , Li Guoyun , Han Feng , Yu Wengong
Published: February 2022

Marine macroalgae, contributing much to the bioeconomy, have inspired tremendous attention as sustainable raw materials. Ulvan, as one of the main structural components of green algae cell walls, can be degraded by ulvan lyase through the β-elimination mechanism to obtain oligosaccharides exhibiting several good physiological activities. Only a few ulvan lyases have been characterized until now. This thesis explores the properties of a new polysaccharide lyase family 25 ulvan lyase TsUly25B from the marine bacterium Thalassomonas sp. LD5. Its protein molecular weight was 54.54 KDa, and it was most active under the conditions of 60 °C and pH 9.0. The Km and kcat values were 1.01 ± 0.05 mg/mL and 10.52 ± 0.28 s−1, respectively. TsUly25B was salt-tolerant and NaCl can significantly improve its thermal stability. Over 80% of activity can be preserved after being incubated at 30 °C for two days when the concentration of NaCl in the solution is above 1 M, while 60% can be preserved after incubation at 40 °C for 10 h with 2 M NaCl. TsUly25B adopted an endolytic manner to degrade ulvan polysaccharides, and the main end-products were unsaturated ulvan disaccharides and tetrasaccharides. In conclusion, our research enriches the ulvan lyase library and advances the utilization of ulvan lyases in further fundamental research as well as ulvan oligosaccharides production.
Donor Splice Site Variant in SLC9A6 Causes Christianson Syndrome in a Lithuanian Family: A Case Report
Authors: Petraitytė Gunda , Mikštienė Violeta , Siavrienė Evelina , Cimbalistienė Loreta , Maldžienė Živilė , Rančelis Tautvydas , Vaitėnienė Evelina Marija , Ambrozaitytė Laima , Dapkūnas Justas , Dzindzalieta Ramūnas , Pranckevičienė Erinija , Kučinskas Vaidutis , Utkus Algirdas , Preikšaitienė Eglė
Published: February 2022

Background and Objectives: The pathogenic variants of SLC9A6 are a known cause of a rare, X-linked neurological disorder called Christianson syndrome (CS). The main characteristics of CS are developmental delay, intellectual disability, and neurological findings. This study investigated the genetic basis and explored the molecular changes that led to CS in two male siblings presenting with intellectual disability, epilepsy, behavioural problems, gastrointestinal dysfunction, poor height, and weight gain. Materials and Methods: Next-generation sequencing of a tetrad was applied to identify the DNA changes and Sanger sequencing of proband’s cDNA was used to evaluate the impact of a splice site variant on mRNA structure. Bioinformatical tools were used to investigate SLC9A6 protein structure changes. Results: Sequencing and bioinformatical analysis revealed a novel donor splice site variant (NC_000023.11(NM_001042537.1):c.899 + 1G > A) that leads to a frameshift and a premature stop codon. Protein structure modelling showed that the truncated protein is unlikely to form any functionally relevant SLC9A6 dimers. Conclusions: Molecular and bioinformatical analysis revealed the impact of a novel donor splice site variant in the SLC9A6 gene that leads to truncated and functionally disrupted protein causing the phenotype of CS in the affected individuals.
Light Metals and Their Composites
Authors: Vorozhtsov Alexander
Published: February 2022

It is known that metallurgy influences almost all sectors of industry, including energy, aeronautics, automotive, space, chemical, machinery, scientific equipment, construction, packaging, electrical, computing and health [...]
Viscoelastic Particle Focusing and Separation in a Spiral Channel
Authors: Feng Haidong , Jafek Alexander R. , Wang Bonan , Brady Hayden , Magda Jules J. , Gale Bruce K.
Published: February 2022

As one type of non-Newtonian fluid, viscoelastic fluids exhibit unique properties that contribute to particle lateral migration in confined microfluidic channels, leading to opportunities for particle manipulation and separation. In this paper, particle focusing in viscoelastic flow is studied in a wide range of polyethylene glycol (PEO) concentrations in aqueous solutions. Polystyrene beads with diameters from 3 to 20 μm are tested, and the variation of particle focusing position is explained by the coeffects of inertial flow, viscoelastic flow, and Dean flow. We showed that particle focusing position can be predicted by analyzing the force balance in the microchannel, and that particle separation resolution can be improved in viscoelastic flows.
Design and Analysis of a Microgripper with Three-Stage Amplification Mechanism for Micromanipulation
Authors: Hong Yuan , Wu Yimin , Jin Shichao , Liu Dayong , Chi Baihong
Published: February 2022

This paper proposes a novel microgripper with two working modes. The microgripper is designed with symmetric structure and each part is actuated by one piezoelectric actuator, respectively. To achieve desired output displacement, each part of the microgripper is designed with three-stage amplification mechanism to amplify the displacement of the PZT actuator. According to the size of the microobjects, the grasping operation can be completed by one finger moving or two fingers moving simultaneously. Then, the theoretical analysis is carried out to calculated the key characteristics, including amplification, input stiffness and frequency. Finite element analysis (FEA) is conducted to optimize the structural parameters and investigate the performance of the microgripper. Finally, a prototype is machined by wire electro-discharge machining (WEDM) method and experiments are carried out to verify the performance of the microgripper. The results indicate that the amplification is 10.41 and the motion stroke of one jaw is 118.34 µm when the input voltage is 100 V. The first natural frequency is 746.56 Hz. By picking and placing the wires with different diameters and slices with different thickness, the grasping stability is verified.
Single Red Blood Cell Hydrodynamic Traps via the Generative Design
Authors: Grigorev Georgii V. , Nikitin Nikolay O. , Hvatov Alexander , Kalyuzhnaya Anna V. , Lebedev Alexander V. , Wang Xiaohao , Qian Xiang , Maksimov Georgii V. , Lin Liwei
Published: February 2022

This paper describes a generative design methodology for a micro hydrodynamic single-RBC (red blood cell) trap for applications in microfluidics-based single-cell analysis. One key challenge in single-cell microfluidic traps is to achieve desired through-slit flowrates to trap cells under implicit constraints. In this work, the cell-trapping design with validation from experimental data has been developed by the generative design methodology with an evolutionary algorithm. L-shaped trapping slits have been generated iteratively for the optimal geometries to trap living-cells suspended in flow channels. Without using the generative design, the slits have low flow velocities incapable of trapping single cells. After a search with 30,000 solutions, the optimized geometry was found to increase the through-slit velocities by 49%. Fabricated and experimentally tested prototypes have achieved 4 out of 4 trapping efficiency of RBCs. This evolutionary algorithm and trapping design can be applied to cells of various sizes.
Simulation of Gold Nanoparticle Transport during MHD Electroosmotic Flow in a Peristaltic Micro-Channel for Biomedical Treatment
Authors: Nuwairan Muneerah Al , Souayeh Basma
Published: February 2022

The study of gold nanoparticles (AuNPs) in the blood flow has emerged as an area of interest for numerous researchers, due to its many biomedical applications, such as cancer radiotherapy, DNA and antigens, drug and gene delivery, in vitro evaluation, optical bioimaging, radio sensitization and laser phototherapy of cancer cells and tumors. Gold nanoparticles can be amalgamated in various shapes and sizes. Due to this reason, gold nanoparticles can be diffused efficiently, target the diseased cells and destroy them. The current work studies the effect of gold nanoparticles of different shapes on the electro-magneto-hydrodynamic (EMHD) peristaltic propulsion of blood in a micro-channel under various effects, such as activation energy, bioconvection, radiation and gyrotactic microorganisms. Four kinds of nanoparticle shapes, namely bricks, cylinders and platelets, are considered. The governing equations are simplified under the approximations of low Reynolds number (LRN), long wavelength (LWL) and Debye–Hückel linearization (DHL). The numerical solutions for the non-dimensional equations are solved using the computational software MATLAB with the help of the bvp4c function. The influences of different physical parameters on the flow and thermal characteristics are computed through pictorial interpretations.
High-Production-Rate Fabrication of Low-Loss Lithium Niobate Electro-Optic Modulators Using Photolithography Assisted Chemo-Mechanical Etching (PLACE)
Authors: Wu Rongbo , Gao Lang , Liang Youting , Zheng Yong , Zhou Junxia , Qi Hongxin , Yin Difeng , Wang Min , Fang Zhiwei , Cheng Ya
Published: February 2022

Integrated thin-film lithium niobate (LN) electro-optic (EO) modulators of broad bandwidth, low insertion loss, low cost and high production rate are essential elements in contemporary interconnection industries and disruptive applications. Here, we demonstrated the design and fabrication of a high performance thin-film LN EO modulator using photolithography assisted chemo-mechanical etching (PLACE) technology. Our device shows a 3-dB bandwidth over 50 GHz, along with a comparable low half wave voltage-length product of 2.16 Vcm and a fiber-to-fiber insertion loss of 2.6 dB. The PLACE technology supports large footprint, high fabrication uniformity, competitive production rate and extreme low device optical loss simultaneously, our result shows promising potential for developing high-performance large-scale low-loss photonic integrated devices.
Facile Synthesis of 3D Printed Tailored Electrode for 3-Monochloropropane-1,2-Diol (3-MCPD) Sensing
Authors: Arris Farrah Aida , Mohan Denesh , Sajab Mohd Shaiful
Published: February 2022

Additive manufacturing (AM) has allowed enormous advancement in technology and material development; thus, it requires attention in developing functionalized printed materials. AM can assist in efficiently manufacturing complex tailored electrodes for electrochemical sensing in the food industry. Herein, we used a commercial fused deposition modeling (FDM) filament of acrylonitrile butadiene styrene (ABS) for FDM 3D printing of a self-designed electrode with minimal time and cost compared to a commercial electrode. A graphene-based ABS conductive filament (ABS-G) was used to fabricate the conductive electrode in a dual-nozzle FDM 3D printer. The electrochemically conductive 3D printed electrode was characterized using cyclic voltammetry and tested against standard 3-monochloropropane-1,2-diol (3-MCPD) with known concentrations using an amperometric detection method. Results showed a basis for promising application to detect and quantify 3-MCPD, a food contaminant known for its carcinogenic potential. The fabrication of functionalized 3D printed polymer electrodes paves way for the development of complete 3D printable electrochemical sensors. Under optimal conditions, this newly synthesized electrochemical sensor exhibited sensitivity with a linear response range from 6.61 × 10−4 to 2.30 × 10−3 µg/mL with an estimated limit of detection of 3.30 × 10−4 µg/mL against 3-MCPD.
Neurological Screening in Elderly Liver Transplantation Candidates: A Single Center Experience
Authors: Avorio Federica , Sparacia Gianvincenzo , Russelli Giovanna , Seidita Aurelio , Mamone Giuseppe , Alduino Rossella , Tuzzolino Fabio , Gruttadauria Salvatore , Miraglia Roberto , Bulati Matteo , Lo Re Vincenzina
Published: February 2022

Background: Cerebral small vessels disease (cSVD) is an age-related disorder and risk factor for stroke and cognitive/motor impairments. Neurological complications (NCs) are among the causes of adverse outcomes in older liver transplant recipients. This study sought to determine whether cSVD predicts acute NCs in over 65-year-old liver transplant patients. Methods: Data were collected, from a retrospective medical chart review, of 22 deceased donor liver transplant recipients aged 65 years or older with a pre-operative brain magnetic resonance imaging (MRI). We used the Fazekas score (0–3) as a quantitative measurement of the vascular lesion load seen in the MRI. We analyzed all post-operative acute NCs occurring during the hospital stay and any other non-NC. Results: cSVD was recognized in all patients. Neurological complications (NCs) occurred in 18.1% of patients with toxic-metabolic encephalopathy the most frequent diagnosis (13.64%). More severe cSVD was associated with seizures (p = 0.0362), longer hospital stay (p 0.0299), and disability (p 0.0134). In our elderly cohort, hepatic encephalopathy (HE) (p 0.0287) and ascites (p 0.0270) were predictors of NCs after liver transplantation. Ascites and/or variceal bleeding and severity of liver disease were associated with adverse post-operative outcomes. The small sample size limited the statistical analysis power. Conclusions: We present the preliminary data of a single-center retrospective study aimed at understanding the cSVD role on NCs and non-NCs after a liver transplantation in elderly patients. This would encourage a more appropriate multicenter prospective study that will definitely confirm if a neurological screening in old age liver transplant candidates is appropriate.
Body Composition Assessment in Mexican Children and Adolescents. Part 2: Cross-Validation of Three Bio-Electrical Impedance Methods against Dual X-ray Absorptiometry for Total-Body and Regional Body Composition
Authors: Lopez-Gonzalez Desiree , Wells Jonathan C. K. , Clark Patricia
Published: February 2022

The aim of our study was to validate three different bioelectrical impedance analysis (BIA) methods for estimating body composition (BC). First, we generated BIA prediction equations based on the 4-C model as the reference method for fat mass (FM) and fat-free mass (FFM), and on dual X-ray absorptiometry (DXA) estimations of appendicular lean mass (ALM) and truncal fat mass (tFM). Then, we performed cross-validation in an independent BMI-, sex-, and Tanner-stratified sample of 450 children/adolescents. The three BIA methods showed good correlation and concordance with DXA BC estimations. However, agreement analyses showed significant biases, with increasing subestimations of FM and tFM, and overestimations of ALM, by all three BIA methods. In conclusion, the three BIA methods analysed in this study, provide valid estimations of BC for total body and body segments, in children and adolescents who are of a healthy weight, overweight, or obese. It should be noted that this validation cannot be extrapolated to other BIA methods.