bluuebunny/crossref_metadata_2025 huggingface dataset:
Instilling the Value of Religious Pluralism as the Effort to Overcome the Religious Conflict
Authors: Safitri Eka
Published: June 2020

This study aims to describe how to instill the value of religious pluralism at An Najah Student Boarding School Purwokerto and analyze how the student efforts in tackling religious conflict. The methodology used in this research is qualitative descriptive methods. In this study, several conclusions were drawn that the Kiyai at An Najah Islamic Boarding School instill the value of religious pluralism for santri through various activities either written  in the Islamic boarding school curriculum or not. Efforts made by santri to overcome conflicts between religious communities are by following organizations based on harmony and being tolerant towards all religious communities. A good understanding of a student towards religious pluralism makes them always able to select which behavior should be carried out and not cause religious conflict.
The Development of Interactive Learning Multimedia for Zakat Lesson
Authors: Hakim Mukhammad Luqman
Published: June 2020

This research aims to produce multimedia learning and provide understanding to students of the importance of paying zakat in accordance with applicable regulations. The research subjects are 33 students of class VII.I at SMPN 7 Kediri. This study uses research and development method of Lee and Owen’s model. The procedures in research and development are needs analysis, design, development, implementation and evaluation. The data analysis uses a closed questionnaire with a Likert scale. This research and development received positive responses from experts and stated that interactive learning multimedia was feasible to use and did not require revision. A whole responses from students stated that this learning multimedia provides a new learning experience and fosters a sense of awareness of the importance and benefits of paying zakat.
Persepsi Peneliti Terhadap Koleksi Perpustakaan Balai Penelitian dan Pengembangan Lingkungan Hidup dan Kehutanan Kupang
Authors: Handisa Rattahpinnusa Haresariu
Published: June 2020

Minat peneliti untuk memanfaatkan koleksi Perpustakaan Cendana pada Balai Penelitian dan Pengembangan Lingkungan Hidup dan Kehutanan Kupang masih rendah. Penelitian ini bertujuan mengidentifikasi persepsi peneliti terhadap relevansi koleksi perpustakaan dengan kegiatan penelitian, ketersediaan dan kemutahiran koleksi, serta faktor penghambat pengembangan koleksi perpustakaan. Penelitian menggunakan metode studi kasus untuk menggali informasi secara mendalam mengenai persepsi peneliti terhadap koleksi perpustakaan. Pengambilan sampel menggunakan teknik extreme sampling dengan melibatkan informan yang memiliki keterkaitan dengan topik penelitian. Jumlah informan sebanyak tiga orang. Data dikumpulkan melalui wawancara, selanjutnya data yang diperoleh dianalisis secara deskriptif. Hasil penelitian menunjukkan mayoritas informan mempersepsikan koleksi perpustakan cukup relevan dengan kegiatan penelitian. Namun, koleksi perpustakaan belum ideal, khususnya ketersediaan dan kemutakhiran koleksi. Mereka juga mempersepsikan faktor luar seperti keterbatasan pendanaan, fasilitas, dan akses penghambat perpustakaan dalam mengembangkan koleksi yang ideal. Penelitian ini merekomendasikan Perpustakaan Cendana untuk (1) menyusun kebijakan pengembangan koleksi sebagai dasar pengembangan koleksi yang berorientasi kebutuhan pengguna dengan mempertimbangkan aspek relevansi, ketersediaan, dan kemutakhiran; (2)
menjalin kerja sama dengan perpustakaan lain dalam rangka meningkatkan ketersediaan dan kemutakhiran koleksi melalui silang layan dan konsorsium.
Implementation of Green Campus-Based Curriculum Model at Islamic Universities in Indonesia
Authors: Jaya Indra
Published: June 2020

This study is aimed to investigate the implementation of green campus-based curriculum model at Islamic universities in Indonesia. In depth interview was conducted to the top leader of universities in order to confirm the application of green campus-based curriculum especially on vision and mission. A set of interviews was also questioned to lecturers to obtain important information regarding with the employment of the model of curriculum related to environmental health they used in classrooms. In addition, supporting data about students from lecturers’ information was also occupied to enrich the data. As a result, the researcher found that all Islamic universities observed in this study imply green campus or environmental aspect points in university’s vision and mission. Less than 100% of lecturers are able to design learning materials related to environmental health as well as implementing it in classrooms. Less than 60% of students can produce environmental work arts as well as having problem solving skills toward surrounding environment. Above all, hose Islamic universities determine similar goals on green campus-based curriculum model i.e. to preserve the environment and aware of surrounding natural issues. At the end, a few suggestions were suggested to the top manager of the Islamic universities concerning with vital element regarding with lecturers’ competencies in developing environmental health learning design that should be noticed and increased.
Cadexómero yodado en el tratamiento de las biopelículas bacterianas de las úlceras crónicas
Authors: Martínez-Pizarro Sandra
Published: June 2020

No disponible
Trastornos psiquiátricos y su asociación con el ciberacoso en una muestra de adolescentes mexicanos
Authors: Flores-Rodríguez Yassel , Martínez-Aguilar Olga , Tapia-Guillen Liliana Guadalupe , Solís-Bravo Marco Antonio , Gatica-Hernández Aymara , Escoto-López José Juan , Vargas-Rizo Tania Lucila , Salinas-Torres Luis Alberto , Navarro-Luna Enrique , Albores-Gallo Lilia
Published: June 2020

No disponible
Geotecnologias no mapeamento da COVID-19 no estado do Amazonas entre os meses de março a junho de 2020
Authors: Neto João Cândido André da , Aleixo Natacha Cintia Regina
Published: June 2020

O objetivo do presente trabalho foi mapear a disseminação dos casos confirmados da COVID-19 no estado do Amazonas, nos meses de março a junho de 2020. Para isso, foram coletados dados dos casos confirmados e óbitos na FVS/AM (Fundação de Vigilância e Saúde do Amazonas), dados vetoriais dos municípios (IBGE, 2019). Foram realizados mapeamentos da difusão espacial da doença no software QGIS 3.4, utilizando métodos de interpolação pelo Inverso da Distância Ponderada (IDW) e de categorização gradual-quantitativa, pautada nas normativas da cartografia temática. Os resultados alcançados pelo mapeamento da difusão espaço-temporal possibilitaram a identificação de aspectos coexistentes da difusão hierárquica no início da pandemia no estado e por contágio ao longo do tempo, e após três meses do primeiro caso no estado, verificou-se um total de 56.026 (cinquenta e seis mil e vinte seis) casos confirmados em 60 (sessenta) dos 62 (sessenta e dois) municípios do estado, que apresentaram casos confirmados de COVID-19. Conclui-se que a espacialização dos dados da COVID-19, possibilitou uma análise de como a doença se difundiu por praticamente todo território do estado, enfatiza-se que as geotecnologias e técnicas de geoprocessamento, mostram-se como ferramentas primordiais para análise do território, pois, permite a atualização de banco dados e elaboração de produtos cartográficos para respostas urgentes que podem contribuir com o planejamento e ações do poder público.
Polydrug use is associated with new HIV infections among men who have sex with men in China: a multicenter cross-sectional survey
Authors: Mao Xiang , Leuba Sequoia I. , Hu Qinghai , Yan Hongjing , Wang Zhe , Lu Lin , Zhuang Minghua , Chen Xi , Fu Jihua , Geng Wenqing , Jiang Yongjun , Shang Hong , Xu Junjie
Published: June 2020

Background: Recreational drug use is popular among men who have sex with men (MSM), while there is limited information about polydrug use and its consequent impact on sexual health and human immunodeficiency virus (HIV) acquisition. Methods: Mixed methods were used to recruit MSM from seven cities in China between 2012 and 2013. Participants were divided into four subgroups based on the number of recreational drugs (RDs) used in the past 6 months. “Polydrug use” was defined as simultaneous use of ≥2 types of RDs. Information on demographics and HIV high-risk behaviors (HIV-HRBs) was collected, and blood samples were tested for recent HIV infection by the BED capture enzyme immunoassay. Results: A total of 4,496 Chinese MSM participated, of which 28.4% used RDs, and 5% were polydrug users. Polydrug users commonly took poppers with one or more types of other RDs (e.g. methamphetamine). Polydrug users were likely to be aged 26–30 years, have low educational attainment, be internal migrants, have a high monthly income, use versatile positions during anal intercourse, and have inadequate knowledge about prevention of HIV infection. As the number of RDs used in the past 6 months increased, the prevalence of HIV-HRBs increased ( P <0.05 for all). The odds of recent HIV infection were higher among those who used one type (aOR = 2.2, 95%CI: 1.5–3.0) or two types of RDs (2.3, 1.0–5.2) in the past 6 months compared with those who did not use RDs. Conclusion: The level and pattern of polydrug use among Chinese MSM were different from high-income countries. Polydrug use had a dose-effect relationship with HIV-HRBs. Polydrug users who have higher levels of RDs use are more likely to engage in various sexual risks, thus may be associated with new HIV infections.
Evaluations of knowledge, skills and practices of insulin storage and injection handling techniques of diabetic patients in Ethiopian primary hospitals
Authors: Netere Adeladlew Kassie , Ashete Eyayaw , Gebreyohannes Eyob Alemayehu , Belachew Sewunet Admasu
Published: June 2020

Background: Insulin is an effective therapeutic agent in the management of diabetes but it is also sensitive to external environment. Consequently, diabetic patients’ adherence to insulin delivery recommendations is critical to its effectiveness. Lack of knowledge, skill, and irrational practices on appropriate insulin delivery techniques can result in therapeutic failure and increased costs of therapy. The aim of this study was to evaluate the knowledge, skills, and practices of insulin storage and injection technique of patients. Methods : An interview-based cross-sectional study was conducted in conveniently selected participants in Northwest Ethiopian primary hospitals from March 1 to May 30, 2019. Knowledge levels were assessed with right or wrong responses and practice was measured by administering a 4-point Likert scale structured questionnaire through face-to-face interviews. Finally, a five-point observational (demonstration) techniques checklist assessed patients’ skills. Results: Among 194 patients approached, 166 participants completed the survey with a response rate of 85.6 %. From these participants, 54.8% were males and the mean age was 38.46±13.8 years . The overall patients’ median knowledge and practice levels on insulin storage and handling techniques were moderately adequate (64.3%) and fair (55.4%), respectively. In patients’ skill assessments, 94.6% showed injection sites, 70% indicated injection site rotations, and 60.75% practiced injection site rotations. Education (p<0.001), duration of insulin therapy (p=0.008) and duration of diabetes (p=0.014) had a significant effect on patients’ knowledge level. Education (p<0.001), occupation (p<0.001), duration of insulin therapy (p=0.001), duration of diabetes (p=0.036) and patients’ knowledge levels (p<0.001) were found to have a significant effects on the patients’ practice level. A Mann-Whitney U test also disclosed that residency, ways to get insulin and mocked injection technique during first training had significant effects on patients’ knowledge levels. Conclusion: The current study revealed that patients had moderately adequate knowledge and fair practice levels on insulin storage and handling techniques. Moreover, patients missed important insulin administration skills. Healthcare professionals and stakeholders can play important roles in educating patients thereby improving the knowledge, practice, and administration techniques of patients.
Bio-organic fertilizers stimulate indigenous soil Pseudomonas populations to enhance plant disease suppression
Authors: Tao Chengyuan , Li Rong , Xiong Wu , Shen Zongzhuan , Liu Shanshan , Wang Beibei , Ruan Yunze , Geisen Stefan , Shen Qirong , Kowalchuk George A.
Published: June 2020

Background: Plant diseases caused by fungal pathogen result in a substantial economic impact on the global food and fruit industry. Application of organic fertilizers supplemented with biocontrol microorganisms ( i.e. bioorganic fertilizers) has been shown to improve resistance against plant pathogens at least in part due to impacts on the structure and function of the resident soil microbiome. However, it remains unclear whether such improvements are driven by the specific action of microbial inoculants, microbial populations naturally resident to the organic fertilizer or the physical-chemical properties of the compost substrate. The aim of this study was to seek the ecological mechanisms involved in the disease suppressive activity of bio-organic fertilizers. Results: To disentangle the mechanism of bio-organic fertilizer action, we conducted an experiment tracking Fusarium wilt disease of banana and changes in soil microbial communities over three growth seasons in response to the following four treatments: bio-organic fertilizer (containing Bacillus amyloliquefaciens W19), organic fertilizer, sterilized organic fertilizer and sterilized organic fertilizer supplemented with B. amyloliquefaciens W19. We found that sterilized bioorganic fertilizer to which Bacillus was re-inoculated provided a similar degree of disease suppression as the non-sterilized bioorganic fertilizer across cropping seasons. We further observed that disease suppression in these treatments is linked to impacts on the resident soil microbial communities, specifically by leading to increases in specific Pseudomonas spp.. Observed correlations between Bacillus amendment and indigenous Pseudomonas spp. that might underlie pathogen suppression were further studied in laboratory and pot experiments. These studies revealed that specific bacterial taxa synergistically increase biofilm formation and likely acted as a plant-beneficial consortium against the pathogen. Conclusion: Together we demonstrate that the action of bioorganic fertilizer is a product of the biocontrol inoculum within the organic amendment and its impact on the resident soil microbiome. This knowledge should help in the design of more efficient biofertilizers designed to promote soil function.
The Association between dietary total antioxidant capacity with the risk of helicobacter pylori infection among adult: a case–control study
Authors: Sohouli Mohammadhassan , Haghshenas Niloufar , Fatahi Somaye
Published: June 2020

Objective

Dietary total antioxidant capacity (TAC) has been assumed as a useful tool to assess the relationship between the cumulative antioxidant food capacity and several chronic disorders. The aim of this study was to evaluate the association between DTAC and risk of Helicobacter pylori in a case-control study.
Methods

This case-control study was carried out among 150 patients with Helicobacter pylori and 302 healthy subjects aged 18–55 years. Dietary data were collected using a validated 168- items quantitative food frequency questionnaire. DTAC was calculated based on the ferric reducing-antioxidant power (FRAP) values that reported by US Department of Agriculture.
Results

The mean age and BMI of the study participants were 38.70 years and 25.86, respectively. Compared with control subjects, participants with H pylori significantly were older and had higher BMI and smoking use. Patients with H pylori compared with control individuals had also lower intake of total fiber, vitamin E, vitamin C, vitamin D, total dairy, whole grain and vegetables. Compared with participants in the lowest tertile of DTAC, those in the highest terrtile had a significantly lower OR for H pylori after further adjustment for potential confounders (Model 2: OR, 0.20; 95% CI, 0.10–0.40; P for trend, < 0.001).
Conclusions

Our findings showed that a high DTAC was associated with a reduced risk of Helicobacter pylori in adult, which reflects the increased intake of natural dietary antioxidants to prevent the progression of Helicobacter pylori. However, further studies are needed to investigate the t relation between DTAC and risk of Helicobacter pylori.
Documentation of Traditional Knowledge Associated with Medicinal Animals in West Gojjam Zone of Amhara Region, Ethiopia
Authors: Motbaynor Manaye Misganaw , Tadesse Nigussie Seboka , Gashaw Abiyselassie Mulatu , Hailu Ashenafi Ayenew
Published: June 2020

Background In Ethiopia, Ethnozoology and Zootherapeutic research is very limited and little attention has been given.The study was designed to investigate and document traditional knowledge associated with medicinal animals in West Gojjam Zone of Javitenan, North Achefer, and Bahir Dar Zuria districts.Methods Ethnozoological data were collected using structured questionnaires and use value (UV), informant consensus factor (ICF), fidelity level (FL), preferential ranking, and paired comparison were analyzed.Results A total of 26 animal species and were identified and recorded as a source medicine to treat 33 types of ailments. Animal derived medicines of Bos indicus , Trigona spp . and Apis mellifera were frequently reported species to treat various ailments. Bos indicus , Trigona spp ., Apis mellifera , Hyaenidae carnivora , and Labeobarbus spp . were the most frequent use value reports (84%, 52%, 43%, 37% and 36%) respectively. Informants reported 25 animal parts to treat ailments. Honey and meat took the highest frequency use report followed by purified butter, Milk, Liver, fatty meat and Cheese stored more than 7 year were described with average ICF value of 69%. Maximum degree of consensus was developed for remedy of evil eye (88%) followed by dry cough, swelling and hepatitis 82% each. Use of animal derived medicine from Liotrigona spp . used to relive dry-cough tend to have the highest FL (80%); followed by Labeobarbus spp . for swelling (33%) and Trigona spp . for dry-cough (30%). Paired comparisons revealed that purified butter > 2 year, Cheese > 7 year, honey of Liotrigona spp . (Yetinign Tazma), and honey of Trigona spp . (Tazma) were the most popular and efficacious animal-derived medicines to cure malaria and ranked 1st , 2nd , 3rd and 4th , respectively.Conclusion and recommendation results of this study recorded the most popular animal derived medicine to cure various ailments. Thus, government must strengthen traditional healers with training, club formation, material and financial support and improve means of protecting their intellectual property rights. Moreover, chemists and pharmacists should be undergo a detailed study to identify which chemical constituent of animal and animal product is responsible for the respective treatment of ailments in the study area.
Elastography reduces over-medical procedures in thyroid nodules: a systematic review and meta-analysis
Authors: Yan Kun , Cheng Wei , Ma jiancang , Han donggang , Xu Xin , Chen Yanni , Li Jie , Li Yiming , Wang Zhiliang , Jie Pengyuan
Published: June 2020

Background

To evaluate the diagnostic performance of elastography in the differentiating the malignancy from thyroid nodule.

Methods

The literature published in English or Chinese prior to December 2019 which diagnosed by elastography in thyroid nodules were reviewed and summarized. According the inclusion and exclusion criteria, the elegant theses were reserved. Quality of each study was evaluated by the qu ality a ssessment of d iagnostic a ccuracy s tudies tool (QUADAS). Comprehensive Meta-Analysis Version 2.0 was used to describe primary results and explore homogeneity. Publication bias analysis was evaluated by Review Manager 5.3. Meta-Disc version 1.4 was applied to explore threshold effect, and pool sensitivity and specificity. A Summary ROC curve was constructed to calculate the area under the curve.

Results

As the heterogeneity was mild, we performance on random effect model. The publication bias was negligible. The elastography showed high accuracy in the diagnosis of malignant. The pooled sensitivity and specificity with corresponding 95% confidence interval were 0.80 (0.78, 0.82) and 0.80 (0.79, 0.81) respectively. AUC of sROC was 0.9087. Sensitivity analysis demonstrated that the pooled estimates were stable and reliable.

Conclusions

The elastography has obvious sensitivity and specificity in differentiate malignant from the thyroid nodule. Several different types of elastography could achieve the same aim, but the cut-off value is associate with the purpose of the screen program and the subtypes of the technique.
Self-awareness in the training of health care professionals: Validation of a group self-awareness questionnaire among Balint groups in China
Authors: Fritzsche Kurt , Shi Lili , Wei Jing , Sha Yue , Xie Yongbiao , He Yanling , Tschuschke Volker , Flatten Guido , Leonhart Rainer
Published: June 2020

Background

Group-related learning processes in relation to oneself and in interaction with others play an important role in the training of health care professionals. However, an instrument to measure self-awareness in professional groups is not yet available in China. The aim of the study is to validate a questionnaire on self-awareness processes among Balint groups in China.
Methods

After a Balint group session, the participants were asked to fill out a group self-awareness questionnaire (G-SAQ) and two internationally validated instruments to assess group therapy research, namely, the Group Climate Questionnaire (GCQ) and the Group Relationship Questionnaire (GRQ).
Results

Fully completed questionnaires from n = 650 participants were analysed. Most participants came from Beijing, Guangzhou and Shanghai; most were female; and the average age was 31.3 years old (SD 8.2). The confirmatory and exploratory factor analysis of the G-SAQ did not show good solutions. Therefore, we developed a model with only one general factor and a Cronbach's alpha = .936. Low-to-moderate correlations between the G-SAQ and the previously validated questionnaires (the GCQ and the GRQ) indicated acceptable convergent and discriminant validity. Most of the responses in terms of self-awareness ranged from “something learned” to “relatively a lot learned”. The assessment of the group leaders was correlated with the level of learning effects.
Conclusions

The Chinese version of the G-SAQ has satisfactory reliability and validity among participants of Balint groups. It could be used as a measure of self-awareness processes in the future.
Investigation of a functionalized self-assembling nanopeptide hydrogel loaded with adipose-derived mesenchymal stem cells to promote vascular regeneration
Authors: Liu Zhanao , Tian Ailing , Yi Xin , Fan Lufeng , Shao Wenchong , Wu Han , Sun Nianfeng
Published: June 2020

Objectives: To investigate the transplantation of a functionalized self-assembling nanopeptide hydrogel loaded with adipose-derived mesenchymal stem cells (AD-MSCs) into a rabbit hindlimb ischemia model and to evaluate its effect in promoting vascular regeneration in ischemic tissues.Methods: Functionalized self-assembling nanopeptide hydrogels were synthesized, and the physical and chemical properties of the hydrogels were observed by electron microscopy. Primary AD-MSCs were isolated, cultured, immunophenotyped, induced to differentiate, and verified. The self-assembling nanopeptide hydrogel was combined with mesenchymal stem cells for the three-dimensional culture of AD-MSCs, and the growth characteristics were investigated. Animal models were injected with AD-MSC-loaded self-assembled peptide hydrogel, and the therapeutic effects on arterial ischemia were analyzed.Results: The pore size of the functionalized self-assembling nanopeptide hydrogel was suitable for cell growth. Stem cells had a tendency for migration, differentiation, and angiogenesis in three-dimensional culture. The experimental results of transplantation into the rabbit hindlimb ischemia model showed that the functionalized self-assembling nanopeptide hydrogel loaded with AD-MSCs had better efficacy than AD-MSC transplantation alone.Conclusion: Functionalized self-assembling nanopeptide hydrogels can be used as scaffold materials for three-dimensional culture of AD-MSCs. Functionalized self-assembling peptide hydrogels combined with AD-MSCs have better therapeutic effects than traditional stem cell therapies and can promote vascular regeneration.
Shenfu Injection Improves Cerebral Microcirculation and Reduces Brain Injury in a Porcine Model of Hemorrhagic Shock
Authors: Wu Junyuan , Li Zhiwei , Yuan Wei , Zhang Qiang , Liang Yong , Zhang Mingqing , Qin Hongjie , Li Chunsheng
Published: June 2020

Background: The aim of this study was to clarify effects of Shenfu infusion (SFI) on cerebral microcirculation and brain injury after hemorrhagic shock (HS).Methods: Twenty-one domestic male Beijing Landrace pigs were randomly divided into three groups: SFI group (SFI, n=8), saline group (SA, n=8) or sham operation group (SO, n=5). In the SFI group, animals were induced to HS by rapid bleeding to a mean arterial pressure of 40 mmHg within 10 minutes and maintained at 40 ± 3 mmHg for 60 minutes. Volume resuscitation (shed blood and crystalloid) and SFI were given after 1 hour of HS. In the SA group, animals received the same dose of saline instead of SFI. In the SO group, the same surgical procedure was performed but without inducing HS and volume resuscitation. The cerebral microvascular flow index (MFI), nitric oxide synthase (NOS) expression, aquaporin-4 expression, interleukin 6, tumor necrosis factor-α (TNF-α) and ultrastructural of microvascular endothelia were measured.Results: Compared with the SA group, SFI significantly improved cerebral MFI after HS. SFI up regulated cerebral endothelial NOS expression, but down regulated interleukin 6, TNF-α, inducible NOS and aquaporin-4 expression compared with the SA group. The cerebral microvascular endothelial injury and interstitial edema in the SFI group were lighter than those in the SA group.Conclusions: Combined application of SFI with volume resuscitation after HS can improve cerebral microcirculation and reduce brain injury.
Outcome of hamstring graft with preserved insertion: Prospective Study with 5 year Follow-up
Authors: Gupta Ravi , Singhal Akash , Mehta Rohil , David Gladson
Published: June 2020

BackgroundAutologous hamstring graft remains to be a commonly used graft for Anterior Cruciate Ligament (ACL) in sportspersons. With less graft failure rates, better mechanical stability and proprioception with preserved insertion hamstring graft, we investigated long term outcomes of hamstring graft with preserved insertion. Methods: 441 sportspersons were enrolled in the study. They were divided into two groups by computerized randomization. In Group I, ACL reconstruction was done using hamstring free graft (STGF), and in Group II, ACL reconstruction was done using hamstring graft with preserved tibial insertion (STGPI). Postoperatively, patients were assessed for graft rupture, knee stability, Lysholm score, tegner activity and WOMAC score.ResultsThe average age of the patients was 24 ± 2 years in group 1 and 27 ± 8.5 years in group 2. At 5 years, the mean KT-1000 difference was 2.01 in group 1 and 1.96 in group 2 (P = 0.77); the mean Lysholm score was 97.80 and 98.60(p = 0.07), respectively; mean WOMAC score was 3.09 and 3.12(p = 0.89) respectively; mean difference between the pre-injury and post-surgery Tegner level of sports activity was 1.78 and 0.54(P < 0.05), respectively and graft failure rate was 4.1% and 7.7%.(p < 0.05), respectively.ConclusionWe report STGPI to be a more viable option than hamstring free graft in sportspersons for ACL reconstruction due to less graft failure rates and better tegner activity score postoperatively. Further, STGPI is an option with low graft failure rate like that of Bone Patellar Tendon Bone graft,with added advantage of not having significant donor site morbidity.Level of EvidenceLevel 1, Randomized Controlled Trial
Prognostic Significance of Pretreatment Albumin to Alkaline Phosphatase Ratio in Human Cancers: A Meta-Analysis
Authors: Wang Yanwen , Sun Yuwen , Xu Wenying , Wang Yan
Published: June 2020

Purpose: To investigate the prognostic value of pretreatment albumin to alkaline phosphatase ratio (AAPR) in human cancers.Methods: Several electronic databases were searched up to Jan 4, 2020 for relevant studies. The prognostic value of AAPR were assessed by pooled hazard ratios (HRs) with their corresponding 95% confidence intervals (CIs). The endpoint events included the overall survival (OS), disease-free survival (DFS), cancer-specific survival (CSS) and progression-free survival (PFS).Results: A total of 15 articles involving 20 studies with 6062 cancer patients were included. Our results proved that low pretreatment AAPR was related with poor OS (HR=1.83, 95% CI: 1.66-2.02; P＜0.001), DFS (HR=1.97, 95% CI: 1.49-2.61; P＜0.001), CSS (HR=1.88, 95% CI: 1.37-2.56; P＜0.001) and PFS (HR=1.74, 95% CI: 1.24-2.43; P=0.001). In addition, the significant correlation between pretreatment AAPR and OS was not affected by the treatment strategy and tumor pathological type.Conclusion: Low pretreatment AAPR is related to poor prognosis in human cancers, and AAPR could be served as a promising prognostic indicator in cancer patients.
Clinical Outcomes and Prognostic Factors of Arthroscopic Bankart Repair for Recurrent Shoulder Instability in Soldiers: A Retrospective Single-Center Analysis
Authors: Li Ji , Qi Wei , Zhang Qiang , Wang Ketao , Li Wei , Wang Haoran , Li Zhongli
Published: June 2020

Background: The optimal surgical treatment of recurrent traumatic anterior shoulder instability remains a debated topic. The soldier is a special population with high-intensity military training of shoulder. The purpose of this study was to evaluate the clinical outcomes of arthroscopic Bankart repair for recurrent shoulder instability in soldiers and identify the related risk factors. Methods: A retrospective single-center analysis was performed for soldiers with recurrent shoulder instability who underwent arthroscopic Bankart repair between 2009 and 2014. The primary outcome measure was recurrence of instability (redislocation or subluxation). Statistical analysis by binary logistic regression analysis was performed for the significance of various risk factors including sex, gender, number of preoperative dislocations (single/recurrent), the time interval between the first dislocation and the surgery (less or more than 6 months), SLAP repair and number of anchors. The functional outcomes were assessed with the visual analog scale (VAS), the American Shoulder and Elbow Surgery Score (ASES) and Rowe stability score preoperatively and at the last follow-up. Results: A total of 95 shoulders were followed for 53.81±9.37 months (range, 38 to 92 months). The overall postoperative recurrent instability rate was 16.84% (16 in 95). The statistical analysis showed significant differences in age (P=0.045, OR=0.818), and the time interval between the first dislocation and surgery (P=0.035, OR=5.289). There was a significant improvement in the mean VAS, ASES, and Rowe scores postoperatively (P<0.05), but the mean VAS and Rowe scores were lower in the patients of recurrence (P=0.022 and 0.034, respectively). Conclusions: This study suggested that surgery within 6 months of the first dislocation may be required for the young soldiers, although several repair techniques exist for anterior shoulder instability, arthroscopic Bankart repair remains a viable option.
Life-threatening cardiogenic shock in a pediatric patient with SARS-CoV-2-associated myocarditis treated with remdesivir: a case description and report of similar cases from the Literature
Authors: Molinari Silvia , Cola Lucia M.D. , Melzi Maria L. , Cattoni Alessandro , Panceri Roberto , Bombino Michela , Lapadula Giuseppe , Biondi Andrea
Published: June 2020

BackgroundChildren are relatively spared from Coronavirus disease 2019 (COVID-19), but some severe cases have been reported. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in children may affect the cardiovascular system. We hereby report about a case of myocarditis evolving to cardiogenic shock in a SARS-CoV-2 positive child.Case presentationAn otherwise healthy 12-year-old patient was admitted with fever, vomiting, diarrhoea and drowsiness, without any respiratory symptoms. He was diagnosed with COVID-19 on nasopharyngeal swab. He developed hypotension and cardiogenic shock. Bedside echocardiography revealed left ventricular impairment with an ejection fraction (LVEF) below 25%. Plasmatic markers of myocardial injury were remarkably raised, as well as inflammatory biomarkers, including procalcitonin (highest recorded value: 66 ng/mL) and interleukin-6 (8209 pg/mL). The child was transferred to Intensive Care Unit and he was treated with catecholamine support, mechanical ventilation and empiric anti-infectious therapy, including broad spectrum antibiotics and the antiviral agent remdesivir. All additional microbiological investigations yielded negative results. We observed a gradual improvement of LVEF within 5 days. A cardiac magnetic resonance confirmed the suspicion of myocarditis. After 21 days of hospitalisation, the child was discharged without sequelae.ConclusionsOur hypothesis is that the child suffered from SARS-CoV-2-induced fulminant myocarditis, probably in the setting of cytokine release syndrome (CRS). The peculiarity of this SARS-CoV-2 infection is the presence of cardiac failure in a previously healthy child without a respiratory illness. The positive outcome is in line with published Literature about the overall better prognosis of COVID-19 children compared to adults. Remdesivir, an investigational antiviral therapy, may have played a role on the clinical improvement of the child.
13C-caffeine breath test results show high dependence of aryl-hydrocarbon receptor SNPs
Authors: Ishii Mchiko , Ishii Yukimoto , Nakayama Tomohisa , Takahashi Yasuo , Asai Satoshi
Published: June 2020

Aim: We investigated the relationship between trimethyl-13C-caffeine breath test (triCBT) and single nucleotide polymorphisms (SNPs) that are related to caffeine metabolism and consumption.Methods: Subjects were 132 young healthy adults (median 21 years: 101 male, 31 female). Subjects completed a questionnaire that enquired about their smoking status, consumption of caffeinated drinks (including coffee, black tea, green tea), height, weight, and body mass index (BMI). DNA was extracted from saliva, and genotyping was performed using TaqMan® SNP Genotyping for cytochrome P4501A2 rs762551, rs2472297, and aryl-hydrocarbon receptor rs4410790. Trimethyl 13C-caffeine (100 mg) was dissolved in distilled water and administered orally. Subsequently, breath samples were collected every 10 mins for 90 mins. Infrared spectroscopy was used to analyze the amount of 13CO2 in the expired breath, and the sum (Δ13CO2) over 90 min (S90m) was calculated.Results: All subjects had genotype CC for rs2472297. S90m was not significantly different among rs762551 genotypes; however, there was a significant difference in S90m among rs4410790 genotypes. Δ13CO2 was significantly affected by rs4410790 SNPs and smoking. The receiver operating characteristic area under the curve was 0.758 when rs4410790 phenotype C was considered positive. When the cutoff value was set to S90m (23.4 ‰), the sensitivity and specificity were 71.4% and 72.1%, respectively.Conclusions: Our results suggest that caffeine demethylation is affected by rs4410790 SNPs and smoking, and that triCBT can be used to identify SNPs in rs4410790.
Analysis of the Corrective Contribution of Strong Halo-femoral Traction in the Treatment of Severe Rigid Nonidiopathic Scoliosis
Authors: Zhang Hongqi , Yang Guanteng , Guo Chaofeng , Liu Jinyang , tang minxing
Published: June 2020

Introduction: Strong halo-femoral traction has been widely used in the field of severe rigid scoliosis correction. The objective of this study was to analyze the corrective contribution of strong halo-femoral traction in the treatment of severe rigid nonidiopathic scoliosis and discuss its meaning.Material and methods: A retrospective review was performed for patients with severe rigid nonidiopathic scoliosis who were treated with halo-femoral traction in our center from December 2008 to December 2015. All cases underwent halo-femoral traction for 2 to 4 weeks before a one-stage posterior operation, and the absolute and relative contribution rates of each orthopedic factor (bending, fulcrum, traction, surgery) were analyzed.Results: A total of 38 patients were included (15 male and 23 female), with a mean age of 16.4± 3.73 years (10-22 years) and follow-up of 55.05 ± 6.63 mos. (range 40-68 mos.). The etiology was congenital in 17 patients, neuromuscular in 14 patients, neurofibromatosis-1 in 3 patients and Marfan syndrome in 2 patients. Congenital high scapular disease with scoliosis was found in 2 patients. The mean coronal Cobb angle of the major curve was 97.99°±11.47° (range 78°–124°), with a mean flexibility of 15.68% ±6.65%. The absolute contribution rate (ACR) of bending was 27.26% ±10.16%, the ACR of the fulcrum was 10.91% ±2.50%, the ACR of traction was 32.32% ±11.41%, and the ACR of surgery was 29.50% ±9.70%. A significant difference in correction was noted between the ACRs of traction and the fulcrum (P < 0.05).Discussion: Strong halo-femoral traction plays a relatively significant role in the treatment of severe rigid nonidiopathic scoliosis while decreasing the risk of operation, and it is a safe and effective method for the treatment of severe rigid nonidiopathic scoliosis.
The Value of 18F-PSMA-1007 PET/CT in Identifying High-Risk Prostate Cancer
Authors: Hong Jun-jie , Liu Bo-le , Wang Zhi-qiang , Tang Kun , Ji Xiao-wei , Yin Wei-wei , Lin Jie , Zheng Xiang-wu
Published: June 2020

Background: Clinical management decisions on prostate cancer (PCa) are often based on a determination of risk. 68Ga-prostate-specific membrane antigen (PSMA)-11-positron-emission-tomography (PET)/ computer-tomography (CT) is an attractive modality to assess biochemical recurrence of PCa, detect metastatic disease and stage of primary PCa, making it a promising strategy for risk stratification. However, due to some limitation of 68Ga-PSMA-11 the development of alternative tracers is of high interest. In this study, we aimed to investigate the value of the new PET trace 18F-PSMA-1007 in identifying high-risk PCa.Methods: 170 patients with primary PCa underwent 18F-PSMA-1007 PET/CT were retrospectively analyzed. According to the European Association of Urology (EAU) guidelines on prostate cancer for PCa, patients were classified into low-intermediate-risk (LMR) group or high-risk (HR) group. The maximum standardized uptake values (SUVmax) of the primary prostate tumor was measured on PET/CT images. The diagnostic performance of PET/CT for LMR and HR PCa were calculated and the relationship between the SUVmax of primary prostate tumor, prostate-specific antigen (PSA) level and Gleason score (GS) were analyzed.Results: Of all 170 patients, 55 patients were classified into LMR group and 115 patients were classified into HR group. There was a significant positive correlation between the PSA level/GS and SUVmax (r = 0.597, r = 0.446, P < 0.001, respectively). Tumors with GS of 6 and 7a showed significantly lower 18F-PSMA-1007 uptake compared to patients with GS of 8, 9, and 10 (P < 0.001). SUVmax in patients of HR was significantly higher than those of LMR (median SUVmax: 20.20 versus 8.40; P < 0.001). In receiver operating characteristic (ROC) curve analysis, the optimal cutoff value of the SUVmax for identifying high-risk PCa was set as 10.78 (area under the curve [AUC]: 0.873; sensitivity: 90.4%; specificity: 69.1%). Conclusion: 18F-PSMA-1007 PET/CT showed the powerful diagnosis efficacy for high-risk PCa, which can be used as an objective imaging reference index for clinical reference.
High Occupational Physical Activity and cardiovascular risk factors in employees of Fomento de Construcciones y Contratas S.A. Company: a cross-sectional study
Authors: Gómez-Recasens Montse , Alfaro-Barrio Silvana , Tarro Lucia , Llauradó Elisabet , Solà Rosa
Published: June 2020

BackgroundThe impact of occupational physical activity (OPA) intensity, considering adults work many hours a day, on health is unknown. The present study aims to evaluate the association between the high intensity of OPA and cardiovascular risk factors of employees.MethodsA cross-sectional study was carried out in the “Fomento de Construcciones y Contratas S.A. Company” (FCC S.A. Delegation) in 2017, Spain. The intensity of OPA of each employee was classified by work categories in low (≤ 3 METs) or high (> 3 METs). Health and lifestyle data of employees were collected on medical consultation in the workplace.ResultsAssociations were analyzed between the high intensity of OPA and cardiovascular risk factors of employees. 751 employees, 55.5% (n = 417) with high intensity of OPA. An 82.2% (n = 245) of employees with low intensity of OPA presented overweight/obesity compared with 69.0% (n = 171) with high intensity of OPA employees (p < 0.001). In men, high intensity of OPA is negatively associated with Body Mass Index (BMI) (B: -0.042, p = 0.003), waist circumference (B: -0.027, p < 0.001) waist-hip ratio (B: -5.484, p < 0.001), cholesterol (B: -0.007, p = 0.001) and triglycerides (B= -0.003, p = 0.025). In women, high intensity of OPA was positively associated with blood pressure (BP) (systolic BP: B = 0.036, p = 0.005 and diastolic BP: B = 0.040, p = 0.021).ConclusionsIn conclusion, the high intensity of OPA is associated with less cardiovascular risk factors in men, whereas women are associated with high levels of blood pressure, suggesting an influence of gender and work categories.
Safety and efficacy of fentanyl combined with midazolam in bronchoscopy under bispectral index-guided conscious sedation
Authors: he qian , zhang sujuan , zhou jun , xu xiong , xu qianqian , qiu hui , guan suhong , han ying , dai pei , zhang qiudi
Published: June 2020

Background: Sedation combined with local anesthesia during bronchoscopy is widely accepted in America and Europe, and receiving great attention in China. This study aimed to investigate the safety and efficacy of fentanyl combined with midazolam for bispectral index (BIS) titrated conscious sedation during bronchoscopy in the Chinese population. Methods: Data from 436 patients who underwent bronchoscopy under local anesthesia (LA group) or BIS-guided conscious sedation combined with local anesthesia (FM group) were retrospectively analyzed. The analysis included vital signs, adverse events recorded during the procedure, and questionnaire information, such as patient tolerance and satisfaction, operator satisfaction, and the cough score noted after the procedure. Results: A total of 225 patients in the LA group, and 211 in the FM group were enrolled in the study. The blood pressure and oxygen saturation were significantly higher in the LA group than in the FM group during bronchoscopy (P<0.001). The heart rate was significantly faster in the LA group at T3max, T3min and T4 than in the FM group. The incidence of hypoxia and bradycardia was higher in the FM group than in the LA group, whereas incidence of hypertension and tachycardia was lower. Patient satisfaction and tolerance of the procedure were significantly better in the FM group. visual analog scale (VAS) scores for cough and operator satisfaction were better in the FM group than in the LA group. Sub-group analysis (inspection, biopsy and transbronchial biopsy guided by radial endobronchial ultrasound (rEBUS-TBB)) indicated that the vital signs, adverse event(hypoxia) and patient satisfaction of the two groups were similar to the previous results. However, the VAS scores for operators’ satisfaction was no significant difference between the two groups in patients undergoing inspection. Conclusions: The conscious sedation regimen of fentanyl combined with midazolam monitored by BIS during bronchoscopy is safe and effective. Although the incidence of hypoxia and bradycardia was higher, the patient’s tolerance and physician’s satisfaction were significantly improved, especially during lengthy procedures, such as intrabronchial biopsy and transbronchial biopsy guided by radial endobronchial ultrasound. Trial registration: The study was approved by the ethics committee of Changzhou first people's Hospital (2019-020).
The Clinical Significance and Potential Molecular Mechanisms of Synaptojanin 2 in Lung Adenocarcinoma
Authors: Lu Hui-Ping , Chen Shang-Wei , He Rong-Quan , Huang Zhi-Guang , Kong Jin-Liang , Zeng Jiang-Hui , Yang Jie , Yang Da-Ping , Mo Jun-Xian , Tang Zhong-Qing , Li Chang-Bo , Ma Fu-Chao , Zhou HuaFu , Chen Gang
Published: June 2020

Background

Lung adenocarcinoma (LUAD) is the main pathological type of pulmonary malignant tumors. Synaptojanin 2 (SYNJ2), a member of the synaptojanin family, is considered as an attractive underlying therapeutic target in several types of cancer. The purpose of the current research was to comprehensively investigate the molecular function and underlying mechanism of SYNJ2 in LUAD with the goal of providing a promising therapeutic target for LUAD.

Methods

We applied tissue microarrays, immunohistochemistry (IHC), high-throughput RNA sequencing (RNA-seq) data, and gene microarrays of public databases to comprehensively examine the protein level, mRNA expression, clinical significance, and prognosis value of SYNJ2 in LUAD. The standard mean difference (SMD) and summary receiver operating characteristic curves (SROC) were computed to evaluate the comprehensive expression value of SYNJ2 in LUAD. Kaplan-Meier survival curves were plotted to determine the overall survival of SYNJ2 with different expression levels in LUAD. Univariate and multivariate cox regression analyses were implemented to investigate the dependent prognostic ability of SYNJ2 expression and the clinically-relevant traits of LUAD. Moreover, SYNJ2 co-expressed genes were screened for Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) function analysis and protein–protein interactions (PPI) network construction.

Results

SYNJ2 overexpression in LUAD was confirmed by 2,299 LUAD samples and 1,387 non-tumor tissues obtained from tissue microarrays along with TCGA and public gene microarrays. The pooled SMD was 1.29 (95% CI: 1.09-1.48, I-square=78.6%, P<0.001) and the area under the curve (AUC) of the SROC was 0.88 (95%CI: 0.85-0.91). Compared to the upregulation of SYNJ2, SYNJ2 downregulation could improve OS in LUAD patients to some extent. SYNJ2 may facilitate the proliferation and progression of LUAD by modulating the cell cycle and TGF-beta signaling pathways. The 10 SYNJ2 co-expressed key genes selected from PPI network were all prominently implicated with the prognosis of LUAD patients.

Conclusion

SYNJ2 may contribute as an attractive and prospective therapeutic target in LUAD.