bluuebunny/crossref_metadata_2025 huggingface dataset:
Safety and Efficacy of Coils in Conjunction With the Pipeline Flex Embolization Device for the Treatment of Cerebral Aneurysms
Authors: Zhang Qianqian , Shao Qiuji , Chang Kaitao , Zhang Hongyun , He Yingkun , Andrade-Barazarte Hugo , Sheng Zhiyuan , Mo Xiao , Zemmar Ajmal , Li Li , Li Tianxiao
Published: October 2021

Background: Flow diverters (FD) have shown promising results in the treatment of intracranial aneurysms (IAs). However, there is still controversy whether pipeline flex embolization device (PED flex)-assisted coils can facilitate the curing of aneurysms. Our aim was to assess the safety and effectiveness of PED flex adjunctive with coils (PED flex + coil) in the treatment of IAs.

Method: Patients who underwent PED flex treatment in combination with coiling between January 2018 and June 2020 were included in this study. The clinical and radiographic characteristics before and after treatments were retrospectively evaluated. The study cohort comprised of 125 patients with 140 IAs, which was subdivided into two subgroups: one group included patients treated only through PED alone, and the other group included patients treated through PED flex adjunctive with coil. Patient baseline characteristics, aneurysm characteristics, treatment-related factors, and outcomes were analyzed to determine the effectiveness of both techniques.

Results: Aneurysms in the PED flex + coil group were larger (10.0 ± 5.8 mm, P < 0.001) and wider (7.2 ± 4.6 mm, P = 0.002) compared with those in the PED flex group. There was no statistical difference in the perioperative complication rate between the two groups. The overall complete occlusion rate was 75.7% at 6.2 months, with 71.7% at 6.2 ± 1.7 months in the PED flex group and 85.4% at 6.2 ± 1.8 months in the PED flex + coil group, respectively. A higher percentage of satisfactory angiography results was found in the PED flex + coil group during follow-up (92.7 vs. 78.8%, P = 0.047).

Conclusion: PED flex placement with adjunctive coil embolization represents a safe alternative option for the treatment of IAs. In these cases, coil embolization increases the occlusion rate in PED flex-treated patients without increasing the periprocedural complications.
Deep Learning-Based Detection of Malformed Optic Chiasms From MRI Images
Authors: Puzniak Robert J. , Prabhakaran Gokulraj T. , Hoffmann Michael B.
Published: October 2021

Convolutional neural network (CNN) models are of great promise to aid the segmentation and analysis of brain structures. Here, we tested whether CNN trained to segment normal optic chiasms from the T1w magnetic resonance imaging (MRI) image can be also applied to abnormal chiasms, specifically with optic nerve misrouting as typical for human albinism. We performed supervised training of the CNN on the T1w images of control participants (n = 1049) from the Human Connectome Project (HCP) repository and automatically generated algorithm-based optic chiasm masks. The trained CNN was subsequently tested on data of persons with albinism (PWA; n = 9) and controls (n = 8) from the CHIASM repository. The quality of outcome segmentation was assessed via the comparison to manually defined optic chiasm masks using the Dice similarity coefficient (DSC). The results revealed contrasting quality of masks obtained for control (mean DSC ± SEM = 0.75 ± 0.03) and PWA data (0.43 ± 0.8, few-corrected p = 0.04). The fact that the CNN recognition of the optic chiasm fails for chiasm abnormalities in PWA underlines the fundamental differences in their spatial features. This finding provides proof of concept for a novel deep-learning-based diagnostics approach of chiasmal misrouting from T1w images, as well as further analyses on chiasmal misrouting and their impact on the structure and function of the visual system.
Lentil and Fava Bean With Contrasting Germination Kinetics: A Focus on Digestion of Proteins and Bioactivity of Resistant Peptides
Authors: Bautista-Expósito Sara , Vandenberg Albert , Peñas Elena , Frias Juana , Martínez-Villaluenga Cristina
Published: October 2021

Germination offers advantages to improve legume protein digestibility as it disintegrates seed structure and hydrolyzes proteins and anti-nutrients. Seed permeability (related to polyphenol content of seed coats) is an important factor affecting the duration of seed germination and its impact on protein digestibility and bioactivity. The objective was to compare the effect of seed germination on protease activity, structure, and proteolysis of four selected legumes with contrasting seed coat polyphenol profiles (gray zero-tannin lentil [GZL], beluga lentil [BL], and dehulled red lentil [DL]; and zero tannin/low vicine–convicine fava bean [ZF]). Protein hydrolysis was characterized during germination and digestion with respect to proteins, peptides, and free amino acids (FAAs). In vitro antihypertensive and antioxidant activities of digests were investigated, and the peptidomic characterization [high-performance liquid chromatography coupled to tandem mass spectrometry (HPLC-MS/MS)] and identification of bioactive fragments in intestinal digests were performed. Regardless of the seed type, germination increased protease activity and reduced the levels of phytic acid, trypsin inhibitors, and tannins (only in BL). A significant proteolysis of the 7S and 11S globulins and a concomitant increase of peptides and FAAs were observed in all sprouted legumes. Digestion kinetics in sprouts revealed a faster generation of FAAs and peptides than in dry seeds, with changes being more evident for DL, associated with a faster imbibition, germination, and sprout growth. In contrast, BL sprouts showed the lowest protein digestibility, likely due to a lower protease activity, seed structure disintegration, and higher anti-nutrient levels in comparison to GZL, DL, and ZF. Moreover, the digestion of sprouts resulted in a higher number of resistant peptides in DL and ZF that matched with previously reported bioactive sequences, suggesting a promising health potential of legume sprouts that was confirmed in vitro. The results suggested that the germination process improved protein digestibility and the health-promoting potential of lentil and fava bean proteins although these changes were more evident in DL due to its rapid imbibition, faster germination, and sprout development. This study will provide important information for either plant breeders to develop legume varieties with permeable seed coats or food producers that could use dehulled seeds for efficient production of sprouts as sustainable food sources of plant proteins with improved nutritional and healthy properties.
Effect of Performance of Soil Cultivator with Different Surface Textures of Shovel Wing
Authors: Wang Ming , Fu Zuoli , Zheng Zhiqi , Huang Yuxiang , Wei Wuquan
Published: October 2021

Cultivating the soil is a necessary measure to ensure the growth of potatoes, and it has a significant impact on potato yield. In this study, a soil cultivator with a textured shovel wing was designed to address the problem that soil cultivators have poor working performance. Based on a combination of discrete element simulation and a digital soil trench verification test, the effects of the structure parameters of the surface textures on the traction resistance and soil fragmentation rate of the soil cultivator with a textured shovel wing were studied. These parameters were optimized to provide a basis for the design of the soil cultivator. The main research results of this paper are as follows. (1) The factors influencing the traction resistance of the soil cultivator were as follows: blade penetration angle > convex hull distance > convex hull diameter. The convex hull diameter was the main factor affecting the soil fragmentation rate. The traction resistance of the soil cultivator with a textured wing was reduced by 9.49%, and the soil fragmentation rate was increased by 10.67%, showing that the quality of soil cultivation was significantly improved. (2) The best parameters for the texture structure of the shovel wing were a blade penetration angle of 26°, a convex hull diameter of 34.4 mm, and a convex hull distance of 28.5 mm. (3) The relative errors between the simulation and the soil trench test for the traction resistance and the soil fragmentation rate were 2.60% and 13.97%, respectively. This study can provide technical support for the design of soil cultivators and is of great significance in improving the quality of soil cultivators.
The Study of Maturational Timing Effect in Elite Portuguese Adolescent Basketball Players: Anthropometric, Functional and Game Performance Implications
Authors: Fragoso Isabel , Ramos Sérgio , Teles Júlia , Volossovitch Anna , Ferreira António Paulo , Massuça Luís Miguel
Published: October 2021

To estimate age at peak height velocity (APHV) in Portuguese male adolescents and; test the effect of maturational status in physical fitness attributes and individual game performance of U-14 basketball players. One mixed-longitudinal cohort with a sample of 439 Portuguese male adolescents and; one cross sectional sample of 172 Portuguese elite U-14 basketball players. The on-time group was defined within a 1-year band (more or less) from mean APHV. Preece-Baines model 1 was adopted to fit the mean stature curve. Independent samples t-tests and Kruskal-Wallis tests were performed and effect size (partial eta square) was calculated. The growth fitting revealed an APHV around 13.45 years for Portuguese male adolescents. Early maturing players exceeded significantly their peers in body size and composition, jump power and upper body strength. Early and on-time maturing players scored better in rebounds won per game (APHV = 13.81, 13.30 years), Performance Index Rating (PIR) and points scored per minute. Maturation influences morphology attributes and strength regardless of the APHV (13.81, 13.45, 13.30 years) used to obtain the cut-off points. It is recommended to use the new Portuguese mean APHV value to avoid extreme classifying bias groups.
Room-Temperature Formation of Hard BCx Films by Low Power Magnetron Sputtering
Authors: Sulyaeva Veronica , Khomyakov Maxim , Kosinova Marina
Published: October 2021

Boron carbide is one of the most important non-metallic materials. Amorphous BCx films were synthesized at room temperature by single- and dual-target magnetron sputtering processes. A B4C target and C target were operated using an RF signal and a DC signal, respectively. The effect of using single- and dual-target deposition and process parameters on the chemical bonding and composition of the films as well as their functional properties were characterized by Fourier transform infrared spectroscopy, Raman spectroscopy, X-ray photoelectron spectroscopy, X-ray energy dispersive analysis, X-ray diffraction, ellipsometry, and spectrophotometry. It was found that the film properties depend on the sputtering power and the used targets. EDX data show that the composition of the samples varied from B2C to practically BC2 in the case of using an additional C target. According to the XPS data, it corresponds to the different chemical states of the boron atom. A nanoindentation study showed that the film with a composition close to B2C deposited with the highest B4C target power reached a hardness of 25 GPa and Young’s modulus of 230 GPa. The optical properties of the films also depend on the composition, so the band gap (Eg) of the BCx film varied in the range of 2.1–2.8 eV, while the Eg of the carbon-rich films decreased to 1.1 eV.
Unsupervised Anomaly Approach to Pedestrian Age Classification from Surveillance Cameras Using an Adversarial Model with Skip-Connections
Authors: Baydargil Husnu Baris , Park Jangsik , Ince Ibrahim Furkan
Published: October 2021

Anomaly detection is an active research area within the machine learning and scene understanding fields. Despite the ambiguous definition, anomaly detection is considered an outlier detection in a given data based on normality constraints. The biggest problem in real-world anomaly detection applications is the high bias of the available data due to the class imbalance, meaning a limited amount of all possible anomalous and normal samples, thus making supervised learning model use difficult. This paper introduces an unsupervised and adversarially trained anomaly model with a unique encoder–decoder structure to address this issue. The proposed model distinguishes different age groups of people—namely child, adult, and elderly—from surveillance camera data in Busan, Republic of Korea. The proposed model has three major parts: a parallel-pipeline encoder with a conventional convolutional neural network and a dilated-convolutional neural network. The latent space vectors created at the end of both networks are concatenated. While the convolutional pipeline extracts local features, the dilated convolutional pipeline extracts the global features from the same input image. Concatenation of these features is sent as the input into the decoder, which has partial skip-connection elements from both pipelines. This, along with the concatenated feature vector, improves feature diversity. The input image is reconstructed from the feature vector through the stacked transpose convolution layers. Afterward, both the original input image and the corresponding reconstructed image are sent into the discriminator and are distinguished as real or fake. The image reconstruction loss and its corresponding latent space loss are considered for the training of the model and the adversarial Wasserstein loss. Only normal-designated class images are used during the training. The hypothesis is that if the model is trained with normal class images, then during the inference, the construction loss will be minimal. On the other hand, if the untrained anomalous class images are input through the model, the reconstruction loss value will be very high. This method is applied to distinguish different age clusters of people using unsupervised training. The proposed model outperforms the benchmark models in both the qualitative and the quantitative measurements.
Sentence Compression Using BERT and Graph Convolutional Networks
Authors: Park Yo-Han , Lee Gyong-Ho , Choi Yong-Seok , Lee Kong-Joo
Published: October 2021

Sentence compression is a natural language-processing task that produces a short paraphrase of an input sentence by deleting words from the input sentence while ensuring grammatical correctness and preserving meaningful core information. This study introduces a graph convolutional network (GCN) into a sentence compression task to encode syntactic information, such as dependency trees. As we upgrade the GCN to activate a directed edge, the compression model with the GCN layers can distinguish between parent and child nodes in a dependency tree when aggregating adjacent nodes. Furthermore, by increasing the number of GCN layers, the model can gradually collect high-order information of a dependency tree when propagating node information through the layers. We implement a sentence compression model for Korean and English, respectively. This model consists of three components: pre-trained BERT model, GCN layers, and a scoring layer. The scoring layer can determine whether a word should remain in a compressed sentence by relying on the word vector containing contextual and syntactic information encoded by BERT and GCN layers. To train and evaluate the proposed model, we used the Google sentence compression dataset for English and a Korean sentence compression corpus containing about 140,000 sentence pairs for Korean. The experimental results demonstrate that the proposed model achieves state-of-the-art performance for English. To the best of our knowledge, this sentence compression model based on the deep learning model trained with a large-scale corpus is the first attempt for Korean.
Effect of Micro-Textured Surfaces and Sliding Speed on the Lubrication Mechanism and Friction-Wear Characteristics of CF/PEEK Rubbing against 316L Stainless Steel under Seawater Lubrication
Authors: Liang Yingna , Gao Jianxin , Gao Dianrong , Sun Yanan , Zhang Zongyi , Zhao Jianhua
Published: October 2021

In this work, the lubrication mechanism and friction-wear characteristics of the friction pair between carbon-fiber-reinforced polyether ether ketone (CF/PPEK) and 316L stainless steel with a micro-hemispherical pit textured surface at different sliding speeds under seawater lubrication were studied through numerical simulation and experimental investigation. The study results indicate that the seawater moves following the sliding direction of the upper specimen, forms a vortex ring flow in the hemispherical pit of the bottom specimen, uses the convergent gap to generate a hydrodynamic effect, produces the bearing capacity, and realizes fluid lubrication. The hemispherical pit diminishes the abrasive wear during the friction process by storing the wear debris, and the main wear forms of the hemispherical-pit surface friction pair are oxidative wear and adhesive wear. The friction coefficient of the hemispherical-pit surface friction pair is 0.018–0.027, the specimen contact temperature is 40.2–55.1 °C, and it is always in the hydrodynamic lubrication state in a rotation speed ranging from 1000 r/min to 1750 r/min. As the sliding speed increases, the specimen contact temperature climbs, and the oxidation reaction gradually becomes full. Oxidative wear and adhesive wear alternately play a dominant role in the friction, and the wear rate first decreases and then increases sharply.
On the Water-Soluble Organic Matter in Inhalable Air Particles: Why Should Outdoor Experience Motivate Indoor Studies?
Authors: Duarte Regina M. B. O. , Duarte Armando C.
Published: October 2021

The current understanding of water-soluble organic aerosol (OA) composition, sources, transformations, and effects is still limited to outdoor scenarios. However, the OA is also an important component of particulate matter indoors, whose complexity impairs a full structural and molecular identification. The current limited knowledge on indoor OA, and particularly on its water-soluble organic matter (WSOM) fraction is the basis of this feature paper. Inspired by studies on outdoor OA, this paper discusses and prioritizes issues related to indoor water-soluble OA and their effects on human health, providing a basis for future research in the field. The following three main topics are addressed: (1) what is known about the origin, mass contribution, and health effects of WSOM in outdoor air particles; (2) the current state-of-the-art on the WSOM in indoor air particles, the main challenges and opportunities for its chemical characterization and cytotoxicity evaluation; and (3) why the aerosol WSOM should be considered in future indoor air quality studies. While challenging, studies on the WSOM fraction in air particles are highly necessary to fully understand its origin, fate, toxicity, and long-term risks indoors.
Artificial Intelligence to Counterweight the Effect of COVID-19 on Learning in a Sustainable Environment
Authors: Subirats Laia , Fort Santi , Atrio Santiago , Sacha Gomez-Monivas
Published: October 2021

Distance learning has been adopted as a very extended model during COVID-19-related confinement. It is also a methodology that can be applied in environments where people do not have easy access to schools. In this study, we automatically classify students as a function of their performance and we describe the best self-learning methodologies in distance learning, which will be useful both in confinement or for people with difficult access to schools. Due to the different learning scenarios provided by the different confinement conditions in the COVID-19 pandemic, we have performed the classification considering data before, during, and after COVID-19 confinement. Using a field experiment of 396 students, we have described the temporal evolution of students during all courses from 2016/2017 to 2020/2021. We have found that data obtained in the last month before the final exam of the subject include the most relevant information for a correct detection of students at risk of failure. On the other hand, students who obtain high scores are much easier to identify. Finally, we have concluded that the distance learning applied in COVID-19 confinement changed not only teaching strategies but also students’ strategies when learning autonomously.
Biotechnological Approaches to Lowering the Ethanol Yield during Wine Fermentation
Authors: Gonzalez Ramon , Guindal Andrea M. , Tronchoni Jordi , Morales Pilar
Published: October 2021

One of the most prominent consequences of global climate warming for the wine industry is a clear increase of the sugar content in grapes, and thus the alcohol level in wines. Among the several approaches to address this important issue, this review focuses on biotechnological solutions, mostly relying on the selection and improvement of wine yeast strains for reduced ethanol yields. Other possibilities are also presented. Researchers are resorting to both S. cerevisiae and alternative wine yeast species for the lowering of alcohol yields. In addition to the use of selected strains under more or less standard fermentation conditions, aerobic fermentation is increasingly being explored for this purpose. Genetic improvement is also playing a role in the development of biotechnological tools to counter the increase in the wine alcohol levels. The use of recombinant wine yeasts is restricted to research, but its contribution to the advancement of the field is still relevant. Furthermore, genetic improvement by non-GMO approaches is providing some interesting results, and will probably result in the development of commercial yeast strains with a lower alcohol yield in the near future. The optimization of fermentation processes using natural isolates is, anyway, the most probable source of advancement in the short term for the production of wines with lower alcohol contents.
Sensing Techniques for Organochlorides through Intermolecular Interaction with Bicyclic Amidines
Authors: Park Jong-Won , Jang Lee-Woon , Jensen Erik C. , Stockton Amanda , Kim Jungkyu
Published: October 2021

Toxic organochloride molecules are widely used in industry for various purposes. With their high volatility, the direct detection of organochlorides in environmental samples is challenging. Here, a new organochloride detection mechanism using 1,5-diazabicyclo[4.3.0]non-5-ene (DBN) is introduced to simplify a sensing method with higher detection sensitivity. Three types of organochloride compounds-trichloroethylene (TCE), dichloromethane (DCM), and dichlorodiphenyltrichloroethane (DDT)—were targeted to understand DCM conjugation chemistry by using nuclear magnetic resonance (NMR) and liquid chromatography with a mass spectrometer (LC-MS). 13C-NMR spectra and LC-MS data indicated that DBN can be labeled on these organochloride compounds by chlorine–nitrogen interaction. Furthermore, to demonstrate the organochloride sensing capability, the labeling yield and limit of detection were determined by a colorimetric assay as well as micellar electrokinetic chromatography (MEKC). The interaction with DBN was most appreciable for TCE, among other organochlorides. TCE was detected at picomolar levels, which is two orders of magnitude lower than the maximum contaminant level set by the United States Environmental Protection Agency. MEKC, in conjunction with this DBN-labeling method, enables us to develop a field-deployable sensing platform for detecting toxic organochlorides with high sensitivity.
CH3NH3PbBr3 Thin Film Served as Guided-Wave Layer for Enhancing the Angular Sensitivity of Plasmon Biosensor
Authors: Wu Leiming , Xiang Yuanjiang , Qin Yuwen
Published: October 2021

CH3NH3PbBr3 perovskite thin film is used as a guided-wave layer and coated on the surface of an Au film to form the Au-perovskite hybrid structure. Using the hybrid structure, a perovskite-based guided-wave surface plasmon resonance (GWSPR) biosensor is proposed with high angular sensitivity. First, it is found that the electric field at the sensing interface is improved by the CH3NH3PbBr3 perovskite thin film, thereby enhancing the sensitivity. The result demonstrates that the angular sensitivity of the Au-perovskite-based GWSPR biosensor is as high as 278.5°/RIU, which is 110.2% higher than that of a conventional Au-based surface plasmon resonance (SPR) biosensor. Second, the selection of the coupling prism in the configuration of the GWSPR biosensor is also analyzed, and it indicates that a low refractive index (RI) prism can generate greater sensitivity. Therefore, the low-RI BK7 prism is served as the coupling prism for the proposed GWSPR biosensor. Finally, the proposed GWSPR sensing structure can not only be used for liquid sensing, but also for gas sensing, and it has also been demonstrated that the GWSPR gas sensor is 2.8 times more sensitive than the Au-based SPR gas sensor.
Roles of Nanostructured Bimetallic Supported on Alumina-Zeolite (AZ) in Light Cycle Oil (LCO) Upgrading
Authors: Pu Jianglong , Zhang Haiping , Wang Min , Rogers Kyle , Wang Hongmei , Wang Hui , Ng Siauw , Sun Ping
Published: October 2021

Light cycle oil (LCO) is one of the major products in Fluid catalytic cracking (FCC) processes, and has drawbacks such as high aromatics, sulfur, and nitrogen contents, and low cetane number (CN). Hydro-upgrading is one of the most typical processes for LCO upgrading, and alumina-zeolite (AZ) is an effective hydrotreating catalyst support. This paper examined the effects of different bimetallic catalysts (CoMo/AZ, NiMo/AZ, and NiW/AZ) supported by AZ on hydro-upgrading of both model compounds and real LCO. CoMo/AZ preferred the direct desulfurization (DDS) route while the NiMo/AZ and NiW/AZ catalysts favored the desulfurization route through hydrogenation (HYD). The presence of nitrogen compounds in the feed introduced a competitive adsorption mechanism and reduced the number of available acid sites. Aromatics were partially hydrogenated into methyltetralines at first, and then further hydrogenated, cracked, and isomerized into methyldecalins, monocyclic, and methyltetralines isomers. CoMo/AZ is the best hydrodesulfurization (HDS) catalyst for the model compounds at low H2 pressure (550 psi) and for LCO at lower temperature (573 K), while NiMo/AZ performs the best for LCO at higher temperature (648 K). NiMo/AZ is the best hydrodenitrogenation (HDN) catalyst for LCO. The hydrodearomatization (HDA) performances of NiMo/AZ and NiW/AZ improved significantly and overwhelmingly higher than that of the CoMo/AZ when the H2 pressure was increased to 1100 psi.
Dual-Modified Cu2S with MoS2 and Reduced Graphene Oxides as Efficient Photocatalysts for H2 Evolution Reaction
Authors: Ha Enna , Xin Zongyuan , Li Danyang , Zhang Jingge , Ji Tao , Hu Xin , Wang Luyang , Hu Junqing
Published: October 2021

Noble metal-free cocatalysts have drawn great interest in accelerating the catalytic reactions of metal chalcogenide semiconductor photocatalyst. In particular, great efforts have been made on modifying a semiconductor with dual cocatalysts, which show synergistic effect of a fast transfer of exciton and energy simultaneously. Herein, we report the dual-modified Cu2S with MoS2 and reduced graphene oxides (Cu2S-MoS2/rGO). The in situ growth of Cu2S nanoparticles in the presence of MoS2/rGO resulted in high density of nanoscale interfacial contacts among Cu2S nanoparticles, MoS2, and rGO, which is beneficial for reducing the photogenerated electrons’ and holes’ recombination. The Cu2S-MoS2/rGO system also demonstrated stable photocatalytic activity for H2 evolution reaction for the long term.
Impact of TiO2 Surface Defects on the Mechanism of Acetaldehyde Decomposition under Irradiation of a Fluorescent Lamp
Authors: Rychtowski Piotr , Tryba Beata , Fuks Hubert , Lillo-Ródenas Maria Ángeles , Román-Martínez Maria Carmen
Published: October 2021

TiO2 was placed in heat-treatment at the temperature of 400–500 °C under flow of hydrogen gas in order to introduce some titania surface defects. It was observed that hole centers in TiO2 were created during its heat treatment up to 450 °C, whereas at 500 °C some Ti3+ electron surface defects appeared. The type of titania surface defects had a great impact on the mechanism of acetaldehyde decomposition under irradiation of artificial visible light. Formation of O•− defects improved both acetaldehyde decomposition and mineralization due to the increased oxidation of adsorbed acetaldehyde molecules by holes. Contrary to that, the presence of electron traps and oxygen vacancies in titania (Ti3+ centers) was detrimental for its photocatalytic properties towards acetaldehyde decomposition. It was proved that transformation of acetaldehyde on the TiO2 with Ti3+ defects proceeded through formation of butene complexes, similar as on rutile-type TiO2. Formed acetic acid, upon further oxidation of butene complexes, was strongly bound with the titania surface and showed high stability under photocatalytic process. Therefore, titania sample heat-treated with H2 at 500 °C showed much lower photocatalytic activity than that prepared at 450 °C. This study indicated the great impact of titania surface defects (hole traps) in the oxidation of acetaldehyde and opposed one in the case of defects in the form of Ti3+ and oxygen vacancies. Oxidation abilities of TiO2 seem to be important in the photocatalytic decomposition of volatile organic compounds (VOCs) such as acetaldehyde.
Assessment of the Hematopoietic Differentiation Potential of Human Pluripotent Stem Cells in 2D and 3D Culture Systems
Authors: Mora-Roldan German Atzin , Ramirez-Ramirez Dalia , Pelayo Rosana , Gazarian Karlen
Published: October 2021

Background. In vitro methods for hematopoietic differentiation of human pluripotent stem cells (hPSC) are a matter of priority for the in-depth research into the mechanisms of early embryogenesis. So-far, published results regarding the generation of hematopoietic cells come from studies using either 2D or 3D culture formats, hence, it is difficult to discern their particular contribution to the development of the concept of a unique in vitro model in close resemblance to in vivo hematopoiesis. Aim of the study. To assess using the same culture conditions and the same time course, the potential of each of these two formats to support differentiation of human pluripotent stem cells to primitive hematopoiesis without exogenous activation of Wnt signaling. Methods. We used in parallel 2D and 3D formats, the same culture environment and assay methods (flow cytometry, IF, qPCR) to investigate stages of commitment and specification of mesodermal, and hemogenic endothelial cells to CD34 hematopoietic cells and evaluated their clonogenic capacity in a CFU system. Results. We show an adequate formation of mesoderm, an efficient commitment to hemogenic endothelium, a higher number of CD34 hematopoietic cells, and colony-forming capacity potential only in the 3D format-supported differentiation. Conclusions. This study shows that the 3D but not the 2D format ensures the induction and realization by endogenous mechanisms of human pluripotent stem cells’ intrinsic differentiation program to primitive hematopoietic cells. We propose that the 3D format provides an adequate level of upregulation of the endogenous Wnt/β-catenin signaling.
FEM Research on Welding Thermal Deformation of Copper Alloy Sheet and Optimization of Welding Sequence
Authors: Yuan Mingxin , Liu Suodong , Sun Hongwei , Gao Yunqiang , Dai Xianling , Chen Weibin
Published: October 2021

To reduce the residual stress and deformation of the copper alloy sheet after welding, and improve the welding quality of the copper alloy sheet, the finite element method (FEM) research on welding thermal deformation and welding sequence optimization was carried out. First, a finite element model of copper alloy sheet welding was established based on ANSYS, the mechanical property parameters of the model at high temperature were determined, and the thermal–structural coupling calculation was performed on the model. Then, the change trend and magnitude of the residual stress and deformation of the model after welding were analyzed. Finally, different welding sequence schemes were designed, and numerical simulation calculations were carried out. The results of the welding sequence solution show that the change trend of the residual stress after welding of the base metal under different welding sequences is basically the same; repeated heating of the base metal at the same position causes large residual stress; the weldment vertical plate is subjected to opposing forces in the x-axis and y-axis directions at the same time. Among four welding schemes, the welding scheme that alternately welds symmetrically from the start and end positions of the weld seam to the middle position of the plate causes the least welding deformation. Compared with the other three schemes, its deformation reduces by 26.6%, 18.3%, and 19.4%, respectively.
Value of 18F-FDG PET/CT for Assessment of Advanced Lacrimal Sac Non-Keratinizing Squamous Cell Carcinoma Successfully Treated with Concurrent Chemoradiotherapy
Authors: Liao Ching-Yu , Huang Li-An , Lin Yu-Hsuan
Published: October 2021

Non-keratinizing squamous cell carcinoma (NKSCC) of the lacrimal apparatus is extremely rare. It is usually very aggressive in destroying local tissue and has a grave prognosis for relentless recurrence and distant failures. Though the current evidence cannot make confident recommendations regarding the best management, curative surgical excision with adjuvant radiotherapy remains the most commonly used strategy. Here, we report a 71-year-old woman presented with progressive right medial canthal swellings for six months. A transnasal endoscopic biopsy revealed NKSCC of the lacrimal sac. She then underwent a combination of magnetic resonance images (MRI) and 2-deoxy-2-(18F)fluoro-D-glucose positron emission tomography/computed tomography (18F-FDG PET/CT) for staging purposes. Following cisplatin-based concurrent chemo-radiotherapy (CCRT), the post-treatment PET/CT illustrated the absence of an abnormal metabolic accumulation over the suspicious region as observed in post-treatment CT. A further trans-ostia re-biopsy confirmed complete tumor remission. This case demonstrates the remarkable ability of 18F-FDG PET/CT to differentiate between a persistent malignancy and post-treatment changes. Furthermore, a definite CCRT might provide comparable outcomes to traditional surgery.
Participation in the Assessment Processes in Problem-Based Learning: Experiences of the Students of Social Sciences in Lithuania
Authors: Lenkauskaitė Jurgita , Bubnys Remigijus , Masiliauskienė Erika , Malinauskienė Daiva
Published: October 2021

The article explores the idea of change in the higher educational process that is implemented via the problem-based learning strategy. Problem-based learning (PBL) is widely understood as an epistemological transformation in higher education. It is emphasized that the transformation should take place throughout the educational process, and assessment is an inseparable and very important part thereof. The study was aimed at revealing the experiences of participation in the assessment processes in PBL of students attending social science programmes in Lithuania. The empirical study, employing a semi-structured interview method, has shown that the students feel empowered when they have the opportunity to assess the entire educational process and (self-)assess the efforts related to the possibilities to become actively engaged in improvement of the assessment strategy. The study has also shown students’ critical approach to the previous experience of assessment in the educational process. Difficulties of student participation in the assessment process in PBL were also identified. They were largely due to the change in the assessment system employed by the teacher and the manifestations of student bias when participating in (self-)assessment.
CHiPReP—A Compiler for the HiPReP High-Performance Reconfigurable Processor
Authors: Weinhardt Markus , Messelka Mohamed , Käsgen Philipp
Published: October 2021

This article presents CHiPReP, a C compiler for the HiPReP processor, which is a high-performance Coarse-Grained Reconfigurable Array employing Floating-Point Units. CHiPReP is an extension of the LLVM and CCF compiler frameworks. Its main contributions are (i) a Splitting Algorithm for Data Dependence Graphs, which distributes the computations of a C loop to Address-Generator Units and Processing Elements; (ii) a novel instruction clustering and scheduling heuristic; and (iii) an integrated placement, pipeline balancing and routing optimization method based on Simulated Annealing. The compiler was verified and analyzed using a cycle-accurate HiPReP simulation model.
Conservative Management of Uterine Adenomyosis: Medical vs. Surgical Approach
Authors: Stratopoulou Christina Anna , Donnez Jacques , Dolmans Marie-Madeleine
Published: October 2021

Uterine adenomyosis is a commonly encountered estrogen-dependent disease in reproductive-age women, causing heavy menstrual bleeding, intense pelvic pain, and infertility. Although adenomyosis was previously considered a disease of multiparous women, it is becoming increasingly evident that it also affects younger nulliparous women and may compromise their fertility potential. It is clear that hysterectomy, the standard approach to definitively manage the disease, is not an option for patients wishing to preserve their fertility, so there is an urgent need to develop novel conservative strategies. We searched the current literature for available methods for conservative management of adenomyosis, including both pharmacological and surgical approaches. There is no existing drug that can cure adenomyosis at present, but some off-label treatment options may be used to tackle disease symptoms and improve fertility outcomes. Adenomyosis in patients wishing to conceive can be ‘treated’ by conservative surgery, though these procedures require highly experienced surgeons and pose a considerable risk of uterine rupture during subsequent pregnancies. While currently available options for conservative management of adenomyosis do have some capacity for alleviating symptoms and enhancing patient fertility perspectives, more effective new options are needed, with gonadotropin-releasing hormone antagonists showing encouraging results in preliminary studies.
Echocardiographic Patterns of Left Ventricular Diastolic Function in Cardiac Amyloidosis: An Updated Evaluation
Authors: Oghina Silvia , Bougouin Wulfran , Kharoubi Mounira , Bonnefous Louis , Galat Arnault , Guendouz Soulef , Bezard Mélanie , Le Bras Fabien , Deux Jean-François , Itti Emmanuel , Moktefi Anissa , Fanen Pascale , Teiger Emmanuel , Mohty Dania , Damy Thibaud , Bodez Diane
Published: October 2021

Aims: Multimodal imaging has allowed cardiac amyloidosis (CA) to be increasingly recognised as a treatable cause of heart failure with preserved ejection fraction, but its prognosis remains poor due to late diagnosis. To assess the left ventricular diastolic function (LVDF) patterns in a large contemporary CA cohort according to the current recommendations and to identify their determinants. Methods and Results: We conducted a monocentric, observational study on a cohort of CA patients from a tertiary CA referral centre. Diastolic function was analysed using standard echocardiography and clinical, laboratory and survival parameters were collected. Four hundred and sixty-four patients with one of the three main type of CA were included: 41% had grade III diastolic dysfunction (restrictive mitral pattern), 25% had grade II diastolic dysfunction, and 25% had grade I diastolic dysfunction; 9% were unclassified. No difference was found between the main CA types. After multivariate analyses, grades II and III were independently associated with dyspnoea, elevated NT-proBNP, cardiac infiltration and systolic dysfunction (global longitudinal strain). Grade I patients had a better prognosis. Conclusions: All LVDF patterns can be observed in CA. One quarter of CA patients have grade I LVDF, reflecting the emergence of earlier stage-related phenotypes with a better prognosis.
Face-Down Posture versus Non-Face-Down Posture following Large Idiopathic Macular Hole Surgery: A Systemic Review and Meta-Analysis
Authors: Tsai Hou-Ren , Chen Tai-Li , Chang Chun-Yu , Huang Huei-Kai , Lee Yuan-Chieh
Published: October 2021

Evidence regarding the effect of a face-down posture (FDP) for large idiopathic macular hole (IMH) is inconsistent. We conducted a systematic review and meta-analysis to determine whether a postoperative FDP is required for the treatment of large IMH. Eligible randomized controlled trials published before September 2021 were retrieved from the Medline, Embase, and Cochrane Library databases. The efficacy outcome was the IMH closure rate and the visual acuity improvement rate. A meta-analysis was performed using a random effects model. The “Grading of Recommendations Assessment, Development, and Evaluation” approach was implemented, and the numbers needed-to-treat (NNTs) were calculated. Seven studies comprising 640 patients were included. We performed a predefined subgroup analysis of IMH size using a cut-off point of 400 µm. Compared with non-FDP, a significant effect of FDP was found in the IMH > 400 µm group (OR = 3.34; 95% CI = 1.57–7.14; trial sequential analysis-adjusted CI = 1.20–11.58; NNTs = 7.9). After stratifying by the posturing periods, the beneficial effect of FDP lasting at least five days, but not three days was observed for large IMH. Maintaining a FDP for at least five days postoperatively is an effective strategy (certainty of evidence: “moderate”) for treating large IMH.
The Usefulness of Urinary Periostin, Cytokeratin-18, and Endoglin for Diagnosing Renal Fibrosis in Children with Congenital Obstructive Nephropathy
Authors: Turczyn Agnieszka , Pańczyk-Tomaszewska Małgorzata , Krzemień Grażyna , Górska Elżbieta , Demkow Urszula
Published: October 2021

Congenital obstructive nephropathy (CON) leads to renal fibrosis and chronic kidney disease. The aim of the study was to investigate the predictive value of urinary endoglin, periostin, cytokeratin-18, and transforming growth factor-β1 (TGF-β1) for assessing the severity of renal fibrosis in 81 children with CON and 60 controls. Children were divided into three subgroups: severe, moderate scars, and borderline lesions based on 99mTc-ethylenedicysteine scintigraphy results. Periostin, periostin/Cr, and cytokeratin-18 levels were significantly higher in the study group compared to the controls. Children with severe scars had significantly higher urinary periostin/Cr levels than those with borderline lesions. In multivariate analysis, only periostin and cytokeratin-18 were independently related to the presence of severe and moderate scars, and periostin was independently related to borderline lesions. However, periostin did not differentiate advanced scars from borderline lesions. In ROC analysis, periostin and periostin/Cr demonstrated better diagnostic profiles for detection of advanced scars than TGF-β1 and cytokeratin-18 (AUC 0.849; 0.810 vs. 0.630; 0.611, respectively) and periostin for detecting borderline lesions than endoglin and periostin/Cr (AUC 0.777 vs. 0.661; 0.658, respectively). In conclusion, periostin seems to be a promising, non-invasive marker for assessing renal fibrosis in children with CON. CK-18 and TGF-β1 demonstrated low utility, and endoglin was not useful for diagnosing advanced scars.
Devastated Bladder Outlet in Pelvic Cancer Survivors: Issues on Surgical Reconstruction and Quality of Life
Authors: Martins Francisco E. , Holm Henriette Veiby , Lumen Nicolaas
Published: October 2021

Bladder outlet obstruction following treatment of pelvic cancer, predominantly prostate cancer, occurs in 1–8% of patients. The high incidence of prostate cancer combined with the long-life expectancy after treatment has increased concerns with cancer survivorship care. However, despite increased oncological cure rates, these adverse events do occur, compromising patients’ quality of life. Non-traumatic obstruction of the posterior urethra and bladder neck include membranous and prostatic urethral stenosis and bladder neck stenosis (also known as contracture). The devastated bladder outlet can result from benign conditions, such as neurogenic dysfunction, trauma, iatrogenic causes, or more frequently from complications of oncologic treatment, such as prostate, bladder and rectum. Most posterior urethral stenoses may respond to endoluminal treatments such as dilatation, direct vision internal urethrotomy, and occasionally urethral stents. Although surgical reconstruction offers the best chance of durable success, these reconstructive options are fraught with severe complications and, therefore, are far from being ideal. In patients with prior RT, failed reconstruction, densely fibrotic and/or necrotic and calcified posterior urethra, refractory incontinence or severe comorbidities, reconstruction may not be either feasible or recommended. In these cases, urinary diversion with or without cystectomy is usually required. This review aims to discuss the diagnostic evaluation and treatment options for patients with bladder outlet obstruction with a special emphasis on patients unsuitable for reconstruction of the posterior urethra and requiring urinary diversion.
The Feasibility and Efficiency of Remote Spirometry System on the Pulmonary Function for Multiple Ribs Fracture Patients
Authors: Liao Chien-An , Young Tai-Horng , Cheng Chi-Tung , Kuo Ling-Wei , Fu Chih-Yuan , Hsu Chih-Po , Chen Szu-An , Tee Yu-San , Hsieh Chih-Hsun , Chen Chih-Chi , Liao Chien-Hung
Published: October 2021

Background: Multiple rib fractures is a common chest trauma with a significant and sustained impact on pulmonary function and quality of life. Continuous monitoring of the pulmonary function parameter was necessary to adjust the therapeutic goals in these patients. We developed an internet-based remote system for lung function monitoring with a remote spirometry and smart device application to follow up these patients consecutively. Method: From Jan 2021 to April 2021, we conducted a prospective study that applied an intelligent spirometry system for patients with multiple rib fractures. With informed consent, we collected clinical data from them and introduced the remote spirometry system. We followed up with these patients for 12 weeks after trauma and compared the recovery of pulmonary function parameters and clinical outcomes. Result: A total of 21 patients were enrolled in our study. We divided them into two groups by the compliance to this remote spirometry system. The improvement of forced vital capacity was better in the good compliance group than the poor compliance group (110% versus 21%, p value 0.049). Moreover, the complication rate was also lower in the good compliance group than the poor compliance group (10% versus 66.7% p value 0.017). Conclusions: Remote spirometry system is a novel system that can help in lung rehabilitation in patients with multiple rib fractures. Patients that cooperate well with this system presented superior lung function improvement and inferior complication rate.