bluuebunny/crossref_metadata_2025 huggingface dataset:
On-farm measurement of the water use and productivity of maize
Authors: Greenwood K. L. , Mundy G. N. , Kelly K. B.
Published: February 2008

Maize, as a C4 species, is likely to use water more productively than the perennial ryegrass and white clover pastures typically grown for dairy cows in northern Victoria. However, only estimates of water use by irrigated maize crops are available for this region. We measured the growth and water use of three commercial maize crops used for silage in northern Victoria. Crops under centre pivot irrigation were monitored in 2003–04 (Spray 1) and 2004–05 (Spray 2). A border-check irrigated crop (Border-check) was monitored in 2004–05. The Spray 1 crop was irrigated 30 times and received 782 mm of rainfall and irrigation. The crop yielded 22 t DM/ha, giving a water productivity of 28 kg DM/ha.mm (including irrigation, rainfall and change in soil water content). In the cooler, wetter summer of 2004–05, the water productivity was 34 kg DM/ha.mm for the Spray 2 crop and 30 kg DM/ha.mm for the Border-check crop. Crop evapotranspiration was estimated from weather data and a daily soil water balance was computed according to FAO 56. The estimated and measured changes in soil water content were in good agreement and indicated that the basal crop coefficients in the model (Kcb = 1.15 during the mid-season, before correction for non-standard humidity and wind speed) were appropriate to local conditions. Maize grown for silage in northern Victoria has higher water productivity than pastures. However, high yields are required to make it economically viable compared with alternative forages for dairy cows. These data will assist dairy farmers to select the optimum forage mix for their enterprises.
Managing mycotoxins in maize: case studies
Authors: Blaney B. J. , K'Keeffe K. , Bricknell L. K.
Published: February 2008

Mycotoxin contamination of Australian maize is neither common nor extensive, but has the capacity to seriously disrupt marketing. Low to moderate levels of aflatoxins and fumonisins can be widespread in some seasons, but zearalenone, nivalenol and deoxynivalenol are usually confined to small growing localities. Possible approaches to such situations were tested by an analysis of several case studies. It is concluded that communication and coordination across the industry, prediction and prevention of contamination, rapid detection and assessment of contamination, effective use of contaminated maize and breeding for resistance comprise a useful set of strategies for managing mycotoxins in maize.
Soil nitrogen dynamics in irrigated maize systems as impacted on by nitrogen and stubble management
Authors: Edis R. B. , Chen D. , Wang G. , Turner D. A. , Park K. , Meyer M. , Kirkby C.
Published: February 2008

The soil nitrogen (N) dynamics of an irrigated maize system in which stubble retention and stubble burned treatments were superimposed over treatments of varying N fertiliser rate were studied. The field site was near Whitton, New South Wales, Australia, and the work described here is part a life cycle analysis of greenhouse gas emissions from maize project. The objective of this part of the work was to quantify the fate of fertiliser N applied at the site. Field measurements of denitrification, mineral N content and recovery of 15N-labelled urea from microplots with and without ammonium thiosulfate were complimented with laboratory studies of denitrification and nitrous oxide (N2O) flux. Significantly (P < 0.05) more fertiliser N was recovered in the grain from the stubble incorporated treatment than the stubble burned treatment and there was greater recovery of fertiliser N in the soil at the end of the experiment in the stubble burned treatment. This may indicate that fertiliser N applied to the stubble burned system may be more exposed to soil-N transformations. The reason for the difference in uptake and soil residual is not clear but may be related to soil structure differences leading to less plant accessibility of N in the burned treatment. This difference may lead to more nitrous oxide emission from soil in the stubble burned treatments. Short-term (1 h) static chamber measurements in the field found a strong N-rate dependence of N2O emission rate for fertiliser rates between 0 and 300 kg N/ha. Inclusion of ammonium thiosulfate in the fertiliser formulation did not appear to have a significant impact on fertiliser N recovery.
Modelling climatic risks of aflatoxin contamination in maize
Authors: Chauhan Y. S. , Wright G. C. , Rachaputi N. C.
Published: February 2008

Aflatoxins are highly carcinogenic mycotoxins produced by two fungi, Aspergillus flavus and A. parasiticus, under specific moisture and temperature conditions before harvest and/or during storage of a wide range of crops including maize. Modelling of interactions between host plant and environment during the season can enable quantification of preharvest aflatoxin risk and its potential management. A model was developed to quantify climatic risks of aflatoxin contamination in maize using principles previously used for peanuts. The model outputs an aflatoxin risk index in response to seasonal temperature and soil moisture during the maize grain filling period using the APSIM’s maize module. The model performed well in simulating climatic risk of aflatoxin contamination in maize as indicated by a significant R2 (P ≤ 0.01) between aflatoxin risk index and the measured aflatoxin B1 in crop samples, which was 0.69 for a range of rainfed Australian locations and 0.62 when irrigated locations were also included in the analysis. The model was further applied to determine probabilities of exceeding a given aflatoxin risk in four non-irrigated maize growing locations of Queensland using 106 years of historical climatic data. Locations with both dry and hot climates had a much higher probability of higher aflatoxin risk compared with locations having either dry or hot conditions alone. Scenario analysis suggested that under non-irrigated conditions the risk of aflatoxin contamination could be minimised by adjusting sowing time or selecting an appropriate hybrid to better match the grain filling period to coincide with lower temperature and water stress conditions.
Analysis of high yielding maize production - a study based on a commercial crop
Authors: Birch C. J. , McLean G. , Sawers A.
Published: February 2008

This paper reports on the use of APSIM – Maize for retrospective analysis of performance of a high input, high yielding maize crop and analysis of predicted performance of maize grown with high inputs over the long-term (>100 years) for specified scenarios of environmental conditions (temperature and radiation) and agronomic inputs (sowing date, plant population, nitrogen fertiliser and irrigation) at Boort, Victoria, Australia. It uses a high yielding (17 400 kg/ha dry grain, 20 500 kg/ha at 15% water) commercial crop grown in 2004–05 as the basis of the study. Yield for the agronomic and environmental conditions of 2004–05 was predicted accurately, giving confidence that the model could be used for the detailed analyses undertaken. The analysis showed that the yield achieved was close to that possible with the conditions and agronomic inputs of 2004–05. Sowing dates during 21 September to 26 October had little effect on predicted yield, except when combined with reduced temperature. Single year and long-term analyses concluded that a higher plant population (11 plants/m2) is needed to optimise yield, but that slightly lower N and irrigation inputs are appropriate for the plant population used commercially (8.4 plants/m2). Also, compared with changes in agronomic inputs increases in temperature and/or radiation had relatively minor effects, except that reduced temperature reduces predicted yield substantially. This study provides an approach for the use of models for both retrospective analysis of crop performance and assessment of long-term variability of crop yield under a wide range of agronomic and environmental conditions.
Reliability of production of quick to medium maturity maize in areas of variable rainfall in north-east Australia
Authors: Birch C. J. , Stephen K. , McLean G. , Doherty A. , Hammer G. L. , Robertson M. J.
Published: February 2008

Maize may assume a more significant role in grain crop production systems in north-east Australia if the probability of producing low yields associated with given amounts of available water can be reduced. Growing hybrids with very early maturity provides a possible way to achieve this. Simulation studies of dryland maize production in areas of highly variable rainfall in north-east Australia were undertaken using long-term weather data input to the APSIM model configured for quick to medium maturity maize. The studies focussed on sowing time options, population density, cultivars, and water availability at sowing. Simulation outputs included predicted mean and median yield, measures of yield variability, and the probability of producing low to very low yield (<2 t/ha). The study showed that optimum sowing date varied with location, and that low populations gave more reliable production, despite some potential yield losses in favourable years. The results of the simulation study provide estimates of yield and thus economic viability of maize production that are interpreted in terms of seasonal variability. They indicate that maize is a viable dryland cropping option provided that cultivar, sowing time and starting water conditions are optimised. Non-optimal conditions of water supply at sowing should be avoided, as greater variability in yield and reduced viability are predicted.
Architectural modelling of maize under water stress
Authors: Birch Colin J. , Thornby David , Adkins Steve , Andrieu Bruno , Hanan Jim
Published: February 2008

Two field experiments using maize (Pioneer 31H50) and three watering regimes [(i) irrigated for the whole crop cycle, until anthesis, (ii) not at all (experiment 1) and (iii) fully irrigated and rain grown for the whole crop cycle (experiment 2)] were conducted at Gatton, Australia, during the 2003–04 season. Data on crop ontogeny, leaf, sheath and internode lengths and leaf width, and senescence were collected at 1- to 3-day intervals. A glasshouse experiment during 2003 quantified the responses of leaf shape and leaf presentation to various levels of water stress. Data from experiment 1 were used to modify and parameterise an architectural model of maize (ADEL-Maize) to incorporate the impact of water stress on maize canopy characteristics. The modified model produced accurate fitted values for experiment 1 for final leaf area and plant height, but values during development for leaf area were lower than observed data. Crop duration was reasonably well fitted and differences between the fully irrigated and rain-grown crops were accurately predicted. Final representations of maize crop canopies were realistic. Possible explanations for low values of leaf area are provided. The model requires further development using data from the glasshouse study and before being validated using data from experiment 2 and other independent data. It will then be used to extend functionality in architectural models of maize. With further research and development, the model should be particularly useful in examining the response of maize production to water stress including improved prediction of total biomass and grain yield. This will facilitate improved simulation of plant growth and development processes allowing investigation of genotype by environment interactions under conditions of suboptimal water supply.
Optimising maize plant population and irrigation strategies on the Darling Downs using the APSIM crop simulation model
Authors: Peake A. S. , Robertson M. J. , Bidstrup R. J.
Published: February 2008

Optimum plant population and irrigation strategies for maize grown in the Dalby district of the Darling Downs in Queensland, Australia, were investigated using the APSIM crop simulation model. After testing the model against three seasons of experimental data, simulation experiments using different irrigation strategies were conducted across a range of plant populations ranging from 20 000 to 80 000 plants/ha, on two soil types with plant available water capacities (PAWC) of 146 mm and 220 mm. All soil type × plant population × irrigation strategy scenarios were simulated using the historical climate record for Dalby from 1889 to 2004, in order to obtain long-term average yield and gross margins (LGM) for each scenario. Soil water was reset to two-thirds of PAWC at sowing in each year. Plant populations required to achieve maximum LGMs ranged from 50 000 to 80 000 plants/ha across the range of scenarios, and were higher than currently recommended by district agronomists for partially irrigated maize. The use of higher plant populations increased season-to-season variability in grain yield and gross margins and may not be a suitable strategy for growers who do not want to increase their risk of crop failure. Partially irrigated maize achieved substantially higher gross margins in years where a positive Southern Oscillation Index phase was recorded in August, and the use of higher plant populations in such years also increased long-term profitability, but also increased the risk of crop failure. Economic gains were achieved by varying the timing and amount of irrigation within a limited available irrigation volume, with a single 100 mm irrigation giving greater LGMs than two 50 mm irrigation events on both soil types, when the irrigation events were scheduled to fill a soil water deficit equal to the effective irrigation volume. However, under full irrigation the use of smaller irrigation volumes increased LGMs on the 146 mm PAWC soil, demonstrating the importance of timely irrigation scheduling on low PAWC soils.
Structural changes in the Mn4Ca cluster and the mechanism of photosynthetic water splitting
Authors: Pushkar Yulia , Yano Junko , Sauer Kenneth , Boussac Alain , Yachandra Vittal K.
Published: February 2008

Photosynthetic water oxidation, where water is oxidized to dioxygen, is a fundamental chemical reaction that sustains the biosphere. This reaction is catalyzed by a Mn4Ca complex in the photosystem II (PS II) oxygen-evolving complex (OEC): a multiprotein assembly embedded in the thylakoid membranes of green plants, cyanobacteria, and algae. The mechanism of photosynthetic water oxidation by the Mn4Ca cluster in photosystem II is the subject of much debate, although lacking structural characterization of the catalytic intermediates. Biosynthetically exchanged Ca/Sr-PS II preparations and x-ray spectroscopy, including extended x-ray absorption fine structure (EXAFS), allowed us to monitor Mn–Mn and Ca(Sr)–Mn distances in the four intermediate S states, S0through S3, of the catalytic cycle that couples the one-electron photochemistry occurring at the PS II reaction center with the four-electron water-oxidation chemistry taking place at the Mn4Ca(Sr) cluster. We have detected significant changes in the structure of the complex, especially in the Mn–Mn and Ca(Sr)–Mn distances, on the S2-to-S3and S3-to-S0transitions. These results implicate the involvement of at least one common bridging oxygen atom between the Mn–Mn and Mn–Ca(Sr) atoms in the O–O bond formation. Because PS II cannot advance beyond the S2state in preparations that lack Ca(Sr), these results show that Ca(Sr) is one of the critical components in the mechanism of the enzyme. The results also show that Ca is not just a spectator atom involved in providing a structural framework, but is actively involved in the mechanism of water oxidation and represents a rare example of a catalytically active Ca cofactor.
Rates of change in natural and anthropogenic radiative forcing over the past 20,000 years
Authors: Joos Fortunat , Spahni Renato
Published: February 2008

The rate of change of climate codetermines the global warming impacts on natural and socioeconomic systems and their capabilities to adapt. Establishing past rates of climate change from temperature proxy data remains difficult given their limited spatiotemporal resolution. In contrast, past greenhouse gas radiative forcing, causing climate to change, is well known from ice cores. We compare rates of change of anthropogenic forcing with rates of natural greenhouse gas forcing since the Last Glacial Maximum and of solar and volcanic forcing of the last millennium. The smoothing of atmospheric variations by the enclosure process of air into ice is computed with a firn diffusion and enclosure model. The 20th century increase in CO
2
and its radiative forcing occurred more than an order of magnitude faster than any sustained change during the past 22,000 years. The average rate of increase in the radiative forcing not just from CO
2
but from the combination of CO
2
, CH
4
, and N
2
O is larger during the Industrial Era than during any comparable period of at least the past 16,000 years. In addition, the decadal-to-century scale rate of change in anthropogenic forcing is unusually high in the context of the natural forcing variations (solar and volcanoes) of the past millennium. Our analysis implies that global climate change, which is anthropogenic in origin, is progressing at a speed that is unprecedented at least during the last 22,000 years.
Lithium delays progression of amyotrophic lateral sclerosis
Authors: Fornai Francesco , Longone Patrizia , Cafaro Luisa , Kastsiuchenka Olga , Ferrucci Michela , Manca Maria Laura , Lazzeri Gloria , Spalloni Alida , Bellio Natascia , Lenzi Paola , Modugno Nicola , Siciliano Gabriele , Isidoro Ciro , Murri Luigi , Ruggieri Stefano , Paparelli Antonio
Published: February 2008

ALS is a devastating neurodegenerative disorder with no effective treatment. In the present study, we found that daily doses of lithium, leading to plasma levels ranging from 0.4 to 0.8 mEq/liter, delay disease progression in human patients affected by ALS. None of the patients treated with lithium died during the 15 months of the follow-up, and disease progression was markedly attenuated when compared with age-, disease duration-, and sex-matched control patients treated with riluzole for the same amount of time. In a parallel study on a genetic ALS animal model, the G93A mouse, we found a marked neuroprotection by lithium, which delayed disease onset and duration and augmented the life span. These effects were concomitant with activation of autophagy and an increase in the number of the mitochondria in motor neurons and suppressed reactive astrogliosis. Again, lithium reduced the slow necrosis characterized by mitochondrial vacuolization and increased the number of neurons counted in lamina VII that were severely affected in saline-treated G93A mice. After lithium administration in G93A mice, the number of these neurons was higher even when compared with saline-treated WT. All these mechanisms may contribute to the effects of lithium, and these results offer a promising perspective for the treatment of human patients affected by ALS.
Letter Perfect
Authors: Van Herk Gerard
Published: February 2008

This paper uses a multivariate analysis of 19th-century letters by semi-literate African American settlers in Liberia to investigate the frequency and distribution of the present perfect (PP) in earlier African American English (AAE). Despite descriptions elsewhere of the PP as marginal to AAE, it occurs here with great frequency, a finding attributed to the sensitivity of the form to genre differences. The linguistic factors conditioning choice between the PP and the preterite match those described for other varieties of English of that time period. This suggests that an English-like PP was part of the core grammar of the writers of these letters.
Public and academic understandings about language
Authors: Kretzschmar William A.
Published: February 2008

The Ebonics controversy revealed surprising public rejection of the ideas of academic linguists. The intellectual history of the situation provides a reasonable explanation. Linguists lack consensus themselves, while the public consensus includes inherent contradictions. Academic and public ideas of language came into conflict over Ebonics in part because linguists attempted to impose their own ideas on the public, in part because of confusion over terminology, and in part because the situation was entangled in social politics. The lessons of the affair suggest an approach to language and public policy in which linguists come to terms with public views of language.
Trauma and Post-Traumatic Stress Disorder Among Homeless Adults in Sydney
Authors: Taylor Kathryn M. , Sharpe Louise
Published: February 2008

Objective: International studies indicate high prevalence rates of post-traumatic stress disorder within homeless populations. In Australia, studies indicate high rates of trauma among homeless adults, yet post-traumatic stress disorder has not been investigated in homeless Australian adults. The primary aim of this project was to determine the prevalence of post-traumatic stress disorder among homeless adults in Sydney. Further, another aim of the study was to determine whether the onset of post-traumatic stress disorder preceded the first episode of homelessness or was a consequence of homelessness.

Method: The sample consisted of 70 homeless men and women aged 18–73 years, who were randomly sampled through eight homeless services. A computer-assisted face-to-face structured clinical interview was conducted with each participant. Lifetime prevalence of post-traumatic stress disorder was determined via the Composite International Diagnostic Interview.

Results: The majority of the sample had experienced at least one traumatic event in their lifetime (98%). Indeed, the mean number of traumas per person was six. The 12 month prevalence of post-traumatic stress disorder was higher among homeless adults in Sydney in comparison to the Australian general population (41% vs 1.5%). But 79% of the sample had a lifetime prevalence of post-traumatic stress. In 59% of cases, the onset of post-traumatic stress disorder preceded the age of the first reported homeless episode.

Conclusions: Homeless adults in Sydney frequently experience trauma and post-traumatic stress disorder. The study found that trauma and post-traumatic stress disorder more often precede homelessness, but re-victimization is common. These findings highlight the high mental health needs among homeless people and have implications for services for homeless people.
How Will Information About the Genetic Risk of Mental Disorders Impact on Stigma?
Authors: Spriggs Merle , Olsson Craig A. , Hall Wayne
Published: February 2008

Objectives: To suggest ways of testing hypotheses about the impact that information on genetic risk may have on the social stigma of mental disorders and to analyse the implications of these hypotheses for genetic screening for mental disorders.

Method: Literature review and critical analysis and synthesis.

Results: An optimistic view is that information on the genetic risk for mental disorders will reduce blame and social stigma experienced by individuals living with mental disorder. A more pessimists view is that genetic risk information and the use of predictive genetic testing will lead to earlier stigmatization of those at risk of mental disorders. Research is identified that is needed to provide a better understanding of the implications of predictive genetic testing for the stigmatization of different mental health disorders.

Conclusions: It is essential that research on the genetics of mental disorders is accompanied by social science research on the ways in which genetic findings influence the lives of those who are tested.
Recovery-Based Practice: Do We Know What We Mean or Mean What We Know?
Authors: Meehan Tom J. , King Robert J. , Beavis Pam H. , Robinson Jacqueline D.
Published: February 2008

The concept of recovery is now widely promoted as the guiding principle for the provision of mental health services in Australia and overseas. While there is increasing pressure on service providers to ensure that services are recovery oriented, the way in which recovery-based practice is operationalized at the coalface presents a number of challenges. These are discussed in the context of five key questions that address (i) the appropriateness of recovery as a focus for service delivery, (ii) the distinction between recovery as a process and an outcome, (iii) the assessment of recovery initiatives, (iv) the alignment of recovery with current service delivery models, and (v) the risks associated with recovery-based practice. It is argued that these questions provide a framework for a debate that must extend beyond patients and providers of mental health services to the broader public, whose attitudes will ultimately determine the possibilities and limits of recovery-oriented practice.
Reliability of Post-Mortem Psychiatric Diagnosis for Neuroscience Research
Authors: Sundqvist Nina , Garrick Therese , Bishop Ian , Harper Clive
Published: February 2008

Objective: The validity of post-mortem human brain research relies upon accurate clinical and psychopathological diagnosis. Current literature indicates few instances where standardized diagnostic assessment tools such as the Diagnostic Instrument for Brain Studies have been utilized. The primary aim of the present study was to investigate the degree of concordance between predominant ante-mortem psychiatric diagnoses indicated in medical records, and post-mortem diagnoses derived through structured diagnostic instruments such as the Diagnostic Instrument for Brain Studies and the Item Group Checklist of the Schedules for Clinical Assessment in Neuropsychiatry.

Methods: Fifty-eight subjects from the New South Wales Tissue Resource Centre, assigned a clinical psychiatric diagnosis after death, were included in the study. The predominant ante-mortem diagnosis of each case was compared to the corresponding post-mortem diagnosis obtained through structured case reviews to which either the Diagnostic Instrument for Brain Studies (from 2001) or the Item Group Checklist of Schedules for Clinical Assessment in Neuropsychiatry (before 2001) were applied.

Results: Comparison of ante-mortem and post-mortem diagnoses produced an overall kappa coefficient of 0.66. Kappa coefficients for the schizophrenia cohort were 0.61, 0.35 for the schizoaffective cohort, 0.95 for the major depressive disorder cohort and 0.70 for the bipolar disorder cohort.

Conclusions: There was moderate–excellent inter-rater reliability for most cohorts in this sample. There was sufficient disagreement, however, particularly for the schizoaffective cohort, to suggest the value of applying a standardized and structured assessment approach to psychiatric diagnosis. A standardized approach would likely enhance both the accuracy of diagnosis and the prospective validity of tissue-based research. The present study also highlights the importance of accurate and detailed medical record keeping at a symptom-based level across all mental health professions. In the absence of clear and adequate symptom-based detail, the reliability of both ante-mortem and post-mortem diagnosis may be compromised.
Self-Inflicted Eye Injuries in First-Episode and Previously Treated Psychosis
Authors: Large Matthew , Andrews Doug , Babidge Nick , Hume Frank , Nielssen Olav
Published: February 2008

The purpose of the present paper was to describe the circumstances and phenomenology of patients who remove or pierce their eyes or orbits during psychotic illness. In particular, the aim was to determine if patients in their first-episode psychosis (FEP) carry an increased risk of self-inflicted eye injury when compared to patients with previously treated psychosis (PTP). Data were extracted from all of the case reports published in English since 1960 and from two unpublished Australian cases. More than half of the cases of self-inflicted eye injury that resulted in permanent loss of vision occurred during FEP. Serious self-inflicted eye injuries are rare, but the risk appears to be greatest during FEP. Earlier treatment of emerging psychosis and close attention to patients who attempt to injure their eyes may occasionally prevent blindness.
Omega-3 Fatty Acids as a Treatment for Perinatal Depression: Randomized Double-Blind Placebo-Controlled Trial
Authors: Rees Anne-Marie , Austin Marie-Paule , Parker Gordon B.
Published: February 2008

Objective: Epidemiological, biological marker and treatment studies, as well as neuroscientific theories, indicate a possible link between omega-3 fatty acids and perinatal depression (PND). Hence the aim of the present study was to assess whether omega-3 fatty acid treatment is superior to placebo in the treatment of PND.

Method: A double-blind randomized placebo-controlled trial was undertaken. Women with major depression during the perinatal period received either fish oil or placebo for six weeks. Changes in depression scores were recorded weekly.

Results: A total of 26 subjects were recruited and there was no significant difference in depression scores between those receiving fish oil and those receiving the placebo.

Conclusions: This is formally a negative study, suggesting that there is no benefit for omega-3 fatty acids over placebo in treating PND. The reason could be that the study was underpowered due to recruitment difficulties and therefore we suggest that it may be unwise to interpret this result as conclusive. Omega-3 is a natural product that is a safe and well-tolerated treatment. Further research is therefore needed in this area to establish whether omega-3 fatty acids are an effective treatment for PND.
Quality of Housing Among Patients of an Area Mental Health Service
Authors: Grigg Margaret , Judd Fiona , Komiti Angela , Ryan Lisa
Published: February 2008

Objectives: The aims of the present study were to (i) assess the quality of housing for patients receiving treatment from an area mental health service; (ii) compare estimates of quality of housing using two different methods: housing type versus housing characteristics; (iii) determine whether either method for assessing quality is more useful that a combination; and (iv) examine the relationship between housing quality and case manager's assessment of the impact of the housing on the patient's mental disorder.

Methods: A survey was developed that included the demographics of the patient; housing type; living arrangements; housing characteristics as assessed by the patient's case manager; and an overall assessment by the case manager of the impact that the housing has on the patient's mental disorder. Case managers were asked to complete the housing survey on all patients they saw in the community during a 2 week period in 2003. The social worker for the inpatient unit completed the survey for all patients admitted to the inpatient unit over a 3 month period.

Results: Surveys were completed for a total of 362 patients. Just under 10% of patients were identified as homeless in that the person either had no housing or was living in a shelter or accommodation frequently associated with homeless persons. Almost half of the patients in the sample had housing that was either not affordable, not secure, not safe or not appropriate to their needs, that is, their housing met at least one of a range of criteria defining poor-quality housing. Sixty-one patients (16.9%) had housing that was considered by their case managers to have a substantial negative impact on their mental illness.

Conclusions: Almost half of the patients treated by an area mental health service appeared to have poor-quality housing. Housing characteristics identified a higher proportion of people with poor-quality housing than did housing type. Case managers’ assessments generally failed to identify a potential negative impact of poor quality housing on the person's mental disorder.
Identifying the Ultra-High Risk (Prodromal) Population: Evaluation of Training Workshops with Mental Health Services
Authors: Nelson Barnaby , Simmons Magenta B. , Yung Alison R. , Buckby Joe A. , O'Dwyer Lisa , Francey Shona M. , Leicester Steven , Bapat Swagata , McGorry Patrick D.
Published: February 2008

Objective: Recent years have witnessed widespread interest in the early phase of psychotic disorders. The most widely used approach to identify individuals in the prodromal phase is the ultra-high risk (UHR) approach, which combines known trait and state risk factors for psychotic disorder. The Personal Assessment and Crisis Evaluvation Clinic introduced the Comprehensive Assessment of At Risk Mental States (CAARMS) in order to assess UHR status. A training DVD and manual in the use of the CAARMS was recently developed in order to assist with UHR identification. The current paper reports the outcome of a series of training workshops with mental health professionals based around this DVD. The research aim was to investigate whether the training workshops assisted mental health professionals in their confidence and ability to accurately identify UHR cases and distinguish these from non-UHR and first-episode psychosis (FEP) cases.

Method: A total of 137 mental health workers participated in the training sessions across eight training sites. The training sessions consisted of four modules: theoretical background; rating written vignettes for UHR, non-UHR or FEP status; viewing and discussing the CAARMS Training DVD; and re-rating matched written vignettes for UHR, non-UHR or FEP status.

Results: Participants’ confidence in identifying UHR cases and in using the CAARMS increased as a result of the workshop. Participants’ ability to correctly identify UHR-positive cases did not improve as a result of the workshop. This may have been the result of a ceiling effect due to the baseline ability to identify UHR-positive cases being high. But there was a trend for participants’ ability to correctly identify UHR-negative cases to improve as a result of the workshop.

Conclusions: UHR training workshops are a valuable means of increasing mental health workers’ confidence in identifying UHR patients. Future UHR training programmes with experienced mental health professionals should pay particular attention to the correct identification of UHR-negative cases.
Binding of cargo sorting signals to AP-1 enhances its association with ADP ribosylation factor 1–GTP
Authors: Lee Intaek , Doray Balraj , Govero Jennifer , Kornfeld Stuart
Published: February 2008

The adaptor protein AP-1 is the major coat protein involved in the formation of clathrin-coated vesicles at the trans-Golgi network. The prevailing view is that AP-1 recruitment involves coincident binding to multiple low-affinity sites comprising adenosine diphosphate ribosylation factor 1 (Arf-1)–guanosine triphosphate (GTP), cargo sorting signals, and phosphoinositides. We now show that binding of cargo signal peptides to AP-1 induces a conformational change in its core domain that greatly enhances its interaction with Arf-1–GTP. In addition, we provide evidence for cross talk between the dileucine and tyrosine binding sites within the AP-1 core domain such that binding of a cargo signal to one site facilitates binding to the other site. The stable association of AP-1 with Arf-1–GTP, which is induced by cargo signals, would serve to provide sufficient time for adaptor polymerization and clathrin recruitment while ensuring the packaging of cargo molecules into the forming transport vesicles.
A microtubule-destabilizing kinesin motor regulates spindle length and anchoring in oocytes
Authors: Zou Jianwei , Hallen Mark A. , Yankel Christine D. , Endow Sharyn A.
Published: February 2008

The kinesin-13 motor, KLP10A, destabilizes microtubules at their minus ends in mitosis and binds to polymerizing plus ends in interphase, regulating spindle and microtubule dynamics. Little is known about kinesin-13 motors in meiosis. In this study, we report that KLP10A localizes to the unusual pole bodies of anastral Drosophila melanogaster oocyte meiosis I spindles as well as spindle fibers, centromeres, and cortical microtubules. We frequently observe the pole bodies attached to cortical microtubules, indicating that KLP10A could mediate spindle anchoring to the cortex via cortical microtubules. Oocytes treated with drugs that suppress microtubule dynamics exhibit spindles that are reoriented more vertically to the cortex than untreated controls. A dominant-negative klp10A mutant shows both reoriented and shorter oocyte spindles, implying that, unexpectedly, KLP10A may stabilize rather than destabilize microtubules, regulating spindle length and positioning the oocyte spindle. By altering microtubule dynamics, KLP10A could promote spindle reorientation upon oocyte activation.
Epidemiology of Hospital-Acquired Infections in Veterans With Spinal Cord Injury and Disorder
Authors: Evans Charlesnika T. , LaVela Sherri L. , Weaver Frances M. , Priebe Michael , Sandford Paul , Niemiec Pamela , Miskevics Scott , Parada Jorge P.
Published: February 2008

Objective.

To describe the epidemiology of hospital-acquired infections (HAIs) in veterans with spinal cord injury and disorder (SCI&D).

Design.

Retrospective medical record review.

Setting.

Midwestern Department of Veterans Affairs spinal cord injury center.

Participants.

A total of 226 patients with SCI&D hospitalized at least once during a 2-year period (October 1, 2001, through September 30, 2003).

Results.

A total of 549 hospitalizations were included in the analysis (mean duration of hospitalization, 33.7 days); an HAI occurred during 182 (33.2%) of these hospitalizations. A total of 657 HAIs occurred during 18,517 patient-days in the hospital (incidence rate, 35.5 HAIs per 1,000 patient-days). Almost half of the 226 patients had at least 1 HAI; the mean number of HAIs among these patients was 6.0 HAIs per patient. The most common HAIs were urinary tract infection (164 [25.0%] of the 657 HAIs; incidence rate, 8.9 cases per 1,000 patient-days), bloodstream infection (111 [16.9%]; incidence rate, 6.0 cases per 1,000 patient-days), and bone and joint infection (103 [15.7%]; incidence rate, 5.6 cases per 1,000 patient-days). The most common culture isolates were gram-positive bacteria (1,082 [45.6%] of 2,307 isolates), including Staphylococcus aureus, and gram-negative bacteria (1,033 [43.6%] of isolates), including Pseudomonas aeruginosa. Multivariate regression demonstrated that predictors of HAI were longer length of hospital stay (P = .002), community-acquired infection (P = .007), and use of a urinary invasive device (P = .01) or respiratory invasive device (P = .04).

Conclusions.

The overall incidence of HAIs in persons with SCI&D was higher than that reported for other populations, confirming the increased risk of HAI in persons with spinal cord injury. The increased risk associated with longer length of stay and with community-acquired infection suggests that strategies are needed to reduce the duration of hospitalization and to effectively treat community-acquired infection, to decrease infection rates. There is significant room for improvement in reducing the incidence of HAIs in this population.
Molecular and Descriptive Epidemiology of Multidrug-Resistant Enterobacteriaceae in Hospitalized Infants
Authors: Anderson Brian , Nicholas Sarah , Sprague Bruce , Campos Joseph , Short Billie , Singh Nalini
Published: February 2008

Objective.

To investigate the epidemiology of multidrug-resistant Enterobacteriaceae (MDRE) in hospitalized infants.

Methods.

From 2000 through 2005, active surveillance cultures for MDRE were performed for patients admitted to a 40-bed neonatal intensive care unit (NICU) that provides care for critically ill infants 6 months of age or younger. MDRE epidemiology and the genetic relatedness of MDRE strains determined by repetitive-sequence polymerase chain reaction were analyzed.

Results.

Active surveillance cultures revealed that 759 (23%) of 3,370 NICU infants (or approximately 1 in 5) developed MDRE colonization or infection and that 613 (72%) of the 853 isolates with epidemiologic data available were healthcare acquired. MDRE colonization occurred more frequently (in 653 infants [86%]) than did MDRE infection (in 106 [14%]). Of the 653 infants with MDRE colonization, 119 (18%) eventually became infected, with 29 (4%) acquiring sterile site infections. The most commonly isolated organisms were the Enterobacter species, accounting for 612 (71%) of the 862 isolates. Molecular epidemiologic analysis revealed that genetic-relatedness clustering (related clusters defined as having a genetic similarity coefficient greater than 95%) varied depending on microbial species. Clustering was detected for 36 (78%) of the 46 Enterobacter aerogenes isolates, 22 (45%) of the 49 Enterobacter cloacae isolates, and 13 (59%) of the 22 Klebsiella pneumoniae isolates.

Conclusion.

Hospitalized infants are at significant risk of acquiring MDRE, specifically Enterobacter species, at the study institution. Active surveillance cultures identified colonized patients who likely contributed to the institutional reservoir of MDRE. Molecular epidemiologic studies suggest that both patient-to-patient transmission and de novo acquisition of resistance play a role in the acquisition of these organisms, and that the clinical significance of such acquisition varies by species. The high percentage of E. aerogenes isolates that demonstrated genetic clustering suggests that monitoring the prevalence of this organism could serve as a useful measure of compliance with infection control procedures.
The Effect of Therapeutic Touch on Pain and Fatigue of Cancer Patients Undergoing Chemotherapy
Authors: Aghabati Nahid , Mohammadi Eesa , Pour Esmaiel Zahra
Published: February 2008

Despite major advances in pain management, cancer pain is managed poorly in 80% of the patients with cancer. Due to deleterious side effects of pharmacology therapy in these people, there is an urgent need for clinical trials of non‐pharmacological interventions. To examine the effect of therapeutic touch (TT) on the pain and fatigue of the cancer patients undergoing chemotherapy, a randomized and three‐groups experimental study—experimental (TT), placebo (placebo TT), and control (usual care)—was carried out. Ninety patients undergoing chemotherapy, exhibiting pain and fatigue of cancer, were randomized into one of the three groups in the Cancer Center of Imam Khomeini Hospital in Tehran, Iran. Pain and fatigue were measured and recorded by participants before and after the intervention for 5 days (once a day). The intervention consisted of 30 min TT given once a day for 5 days between 10:00 a.m. and 10:30 a.m. The Visual Analogue Scale (VAS) of pain and the Rhoten Fatigue Scale (RFS) were completed for 5 days before and after the intervention by the subjects. The TT (significant) was more effective in decreasing pain and fatigue of the cancer patients undergoing chemotherapy than the usual care group, while the placebo group indicated a decreasing trend in pain and fatigue scores compared with the usual care group.
Asian copepods on the move: recent invasions in the Columbia–Snake River system, USA
Authors: Cordell Jeffery R. , Bollens Stephen M. , Draheim Robyn , Sytsma Mark
Published: February 2008

Cordell, J. R., Bollens, S. M., Draheim, R., and Sytsma, M. 2008. Asian copepods on the move: recent invasions in the Columbia–Snake River system, USA. – ICES Journal of Marine Science, 65: 753–758. Nine Asian copepod species have been introduced into the Northeast Pacific, seven of which are largely confined to the San Francisco estuary. However, several of these copepods recently invaded the Columbia–Snake River system in Washington state, USA. In addition to the calanoid copepod Pseudodiaptomus inopinus, which appeared in the 1980s, the Columbia River now has populations of the calanoids Pseudodiaptomus forbesi and Sinocalanus doerrii, and the cyclopoid copepod Limnoithona tetraspina. Sampling in the Columbia–Snake River system in 2005 and 2006 indicated that (i) newer invaders may have displaced the previously introduced P. inopinus; (ii) P. forbesi had moved upstream into the first five reservoirs in the system; (iii) the other species occurred only in the tidal regions of the lower river; (iv) P. forbesi dominates the late summer holoplankton in the lower river and estuary; and (v) P. forbesi is relatively rare, and the holoplankton is dominated by native species in upstream free-flowing segments of the Columbia River and in reservoirs of the Snake River. Zooplankton samples from ships in Puget Sound suggest that ballast water from California is a major source of the introduced copepods and that the Columbia River itself may be a new source of ballast-introduced copepods.
Development and application of a phylogenomic toolkit: Resolving the evolutionary history of Madagascar’s lemurs
Authors: Horvath Julie E. , Weisrock David W. , Embry Stephanie L. , Fiorentino Isabella , Balhoff James P. , Kappeler Peter , Wray Gregory A. , Willard Huntington F. , Yoder Anne D.
Published: February 2008

Lemurs and the other strepsirrhine primates are of great interest to the primate genomics community due to their phylogenetic placement as the sister lineage to all other primates. Previous attempts to resolve the phylogeny of lemurs employed limited mitochondrial or small nuclear data sets, with many relationships poorly supported or entirely unresolved. We used genomic resources to develop 11 novel markers from nine chromosomes, representing ∼9 kb of nuclear sequence data. In combination with previously published nuclear and mitochondrial loci, this yields a data set of more than 16 kb and adds ∼275 kb of DNA sequence to current databases. Our phylogenetic analyses confirm hypotheses of lemuriform monophyly and provide robust resolution of the phylogenetic relationships among the five lemuriform families. We verify that the genus Daubentonia is the sister lineage to all other lemurs. The Cheirogaleidae and Lepilemuridae are sister taxa and together form the sister lineage to the Indriidae; this clade is the sister lineage to the Lemuridae. Divergence time estimates indicate that lemurs are an ancient group, with their initial diversification occurring around the Cretaceous-Tertiary boundary. Given the power of this data set to resolve branches in a notoriously problematic area of primate phylogeny, we anticipate that our phylogenomic toolkit will be of value to other studies of primate phylogeny and diversification. Moreover, the methods applied will be broadly applicable to other taxonomic groups where phylogenetic relationships have been notoriously difficult to resolve.
Estimating heroin epidemics with data of patients in methadone maintenance treatment, collected during a single treatment day
Authors: Nordt Carlos , Stohler Rudolf
Published: February 2008

Aims  Effects of differing drug policies are difficult to evaluate, because time trends in the spread of heroin use, the most problematic illicit drug world‐wide, are unknown in almost all countries. We aimed to develop a simple method to estimate these dynamics with data that can be gathered from patients in substitution treatment within a single day.

Design  We tested the assumption that being in substitution treatment on any day depends solely upon individual time since onset of regular heroin use (following a ‘general inclusion function’). We used data from the case register for substitution treatments in the canton of Zurich (1992–2004), comprising 9518 patients, to model a ‘general inclusion function’. Applying this function, we calculated 30 incidence curves for heroin dependence, each with data of one of 30 randomly chosen treatment days between 1992 and 2004.

Findings  Incidence modelling led to 30 similar curves, and therefore our hypothesis was corroborated. Additionally, our approach also revealed a restricted access to substitution treatment in the early 1990s and a decline in demand due to the introduction of heroin‐assisted treatment from 1994 onwards.

Conclusions  In the canton of Zurich, the probability of being in substitution treatment can be described by a ‘general inclusion function’, and therefore dynamics of heroin epidemics can be estimated based on data of a single treatment day. Adaptation of our function to areas with a more restricted access to substitution treatment may permit these estimations also in other regions or countries. Thus, our approach facilitates the urgently needed assessment of the effects of different drug policies.