bluuebunny/crossref_metadata_2025 huggingface dataset:
Surgical resection following chemoradiotherapy for thoracic SMARCA4-deficient undifferentiated tumor: a report of two cases
Authors: Takei Kensuke , Isaka Mitsuhiro , Wasa Junji , Kawata Takuya , Masuda Tatsuya , Katsumata Shinya , Maeda Koki , Kojima Hideaki , Konno Hayato , Ohde Yasuhisa
Published: November 2024

Background

Thoracic SMARCA4-deficient undifferentiated tumor (SMARCA4-UT) is a high-grade malignant neoplasm with a poor prognosis. Most cases of SMARCA4-UT have extensive chest wall and mediastinum involvement. The efficacy of surgical resection has not been clearly established. Here, we report two surgical cases of SMARCA4-UT with chest wall invasion after chemoradiotherapy.

Case presentation

The first patient was a 40-year-old man with back pain. Computed tomography revealed a 6.8 cm mass in contact with the thoracic vertebrae near the intervertebral foramen, which was suspected to involve the third to fifth ribs. The patient was diagnosed with SMARCA4-UT with clinical T3N0M0 stage IIB. The tumor shrank after chemoradiotherapy, and conversion surgery combined with partial vertebrectomy was performed. Histopathological findings revealed 30% residual tumor in the tumor bed. Thirty-six days after surgery, the patient developed multiple liver metastases and peritoneal dissemination. Chemotherapy combined with immune checkpoint inhibitor treatment was performed, resulting in tumor shrinkage. However, peritoneal dissemination recurred within a short interval. The patient died 5 months postoperatively. The second patient was a 74-year-old man with chest pain. Computed tomography revealed a 7.4-cm mass in the left upper lobe with invasion of the third and fourth ribs. The patient was initially diagnosed with non-small cell lung cancer with clinical T4N1M0 stage IIIA. The tumor shrank after induction chemoradiotherapy, and a left upper lobectomy combined with the chest wall resection was performed. Based on histopathological findings, the patient was diagnosed with SMARCA4-UT. The residual tumor percentage was 3%. The patient was followed up for 12 months postoperatively without recurrence.

Conclusions

We performed the complete resection of SMARCA4-UT following chemoradiotherapy. The two surgical cases had different postoperative courses. Radical surgery after chemoradiotherapy is effective for local control. However, its long-term prognostic efficacy remains unclear. Multidisciplinary approaches and further investigations of novel therapeutic options are required.
Morning versus Nocturnal Heart Rate and Heart Rate Variability Responses to Intensified Training in Recreational Runners
Authors: Nuuttila Olli-Pekka , Kyröläinen Heikki , Kokkonen Veli-Pekka , Uusitalo Arja
Published: November 2024

Background

Resting heart rate (HR) and HR variability (HRV) are widely used parameters to assess cardiac autonomic nervous system function noninvasively. While resting assessments can be performed during sleep or after awakening, it would be relevant to know how interchangeable the results of these measurements are. This study aimed at examining the alignment between nocturnal and morning assessments during regular endurance training and in response to intensive training. A total of 24 recreational runners performed a 3-week baseline period (BL) and a 2-week overload (OL) period (Lucia’s training impulse + 80%). Their running performance was assessed with a 3000-m running test after the BL and OL. The participants recorded daily their nocturnal HR and HRV (the natural logarithm of the root mean square of successive differences; LnRMSSD) with a photoplethysmography-based wrist device and performed an orthostatic test (2-min supine, 2-min standing) every morning with a chest-strap HR sensor. The HR and LnRMSSD segments that were analyzed from the nocturnal recordings included start value (SleepStart), end value (SleepEnd), first 4-h segment 30 min after detected sleep onset (Sleep4h), and full sleep time (SleepFull). The morning segments consisted of the last-minute average in both body positions. All segments were compared at BL and in response to the 3000-m test and OL.

Results

All nocturnal HR and LnRMSSD segments correlated with supine and standing segments at BL (r = 0.42 to 0.91, p < 0.05). After the 3000-m test, the HR increased and LnRMSSD decreased only in the SleepStart, Sleep4h, and SleepFull segments (p < 0.05). In response to the OL, the standing HR decreased (p < 0.01), while the LnRMSSD increased (p < 0.05) in all segments except for SleepStart. The Pearson correlations between relative changes in nocturnal and morning segments were − 0.11 to 0.72 (3000-m) and − 0.25 to 0.79 (OL). The OL response in Sleep4h HR and LnRMSSD correlated with the relative change in 3000-m time (r = 0.63, p = 0.001 and r=-0.50, p = 0.013, respectively).

Conclusions

Nocturnal and morning HR and LnRMSSD correlated moderately or highly in the majority of cases during the BL, but their responses to intensive training were not similarly aligned, especially in LnRMSSD. The nocturnal segments seemed to be sensitive to physical loading, and their responses were associated with the performance-related training responses.
Australian private healthcare staff perspectives on patient reported experience measures (PREMs): a qualitative interview study
Authors: Verlis Krista , McCaffery Kirsten , Copp Tessa , Dodd Rachael , Nickel Brooke , Laidsaar-Powell Rebekah
Published: November 2024

Objective

Patient reported experience measures (PREMs) are common tools utilised in hospitals to support quality improvements, allow consumers to provide feedback on care experiences and can be used to support consumers’ hospital selections. This study aimed to understand the views and opinions of private hospital staff on PREM use and the utility of PREMs as a consumer decision-making tool.

Method

Qualitative, semi-structured interview study conducted via telephone between March-June 2023. Participants (n = 10) were recruited from major private healthcare providers in Australia with half representing hospital-based staff and the other half corporate head office staff who work in patient experience and quality. Interviews were audio-recorded, transcribed, and analysed thematically.

Results

PREM benefits included an understanding of patient experience that improved provision of patient centred care with feedback acting as catalyst for change, to corporate-level strategic initiatives that address specific issues. Drawbacks of PREM reporting included concerns around skewed results by biased respondents, and completion based on hard to alter items (e.g., infrastructure) or on matters outside of hospital control (e.g., insurance). Staff had mixed reactions to consumers using PREMs results when selecting a hospital, some advocated for transparency while others feared consumers would misinterpret the data.

Conclusions

Improved real-time reporting of PREMs, learning from other industries about recording customer experience, and mandatory reporting by private hospitals could further the benefits of PREM measurement in private healthcare. Recognised was the need for PREMs to be displayed in a readily understood way so those with limited health literacy can correctly interpret.
Masson tumor of the right atrial appendage presenting as cardiac tamponade: a case report
Authors: Kanj Mouhammad , Naderi Samah , Khalil Majed , El Khoury Nabil , Mansour Ziad , Chami Rock
Published: November 2024

Background

Intravascular papillary endothelial hyperplasia (Masson tumor) is a rare, benign vascular tumor characterized by the proliferation of endothelial cells within blood vessels. While it typically affects the skin and subcutaneous tissues, it can occasionally appear in unusual locations.

Case presentation

We report a rare case of Masson tumor located in the right atrial appendage of a healthy individual. This case was complicated by atrial wall rupture and subsequent cardiac tamponade. The tumor was successfully resected under cardiopulmonary bypass.

Conclusion

This case highlights a rare occurrence of Masson tumor in the heart, emphasizing the importance of prompt surgical intervention to prevent life-threatening complications such as cardiac tamponade.
Percutaneous radiofrequency ablation for stage B1 of modified Bolondi’s subclassification for intermediate-stage hepatocellular carcinoma
Authors: Eid Ragaey Ahmad , Abdel Fattah Ali M. , Haseeb Alaa Farouk , Hamed Ahmed Moheyeldien , Shaker Marwa Abdallah
Published: November 2024

Background

Hepatocellular carcinoma is considered  the most common cause of hepatic focal lesions in Egypt. TACE is still the recommended treatment approach for patients in the intermediate stage. In the current research, we evaluated the safety and efficacy of percutaneous radiofrequency ablation (RFA) for a selected category in the intermediate stage (BCLC stage B).

Methods

This prospective study was conducted in the Department of Gastroenterology, Hepatology, Faculty of Medicine, Beni-Suef University between September 2022, and March 2024. In addition to AFP, Pelviabdominal ultrasound and computerized tomography (CT) were used for HCC diagnosis. According to the Child–Pugh score plus Milan and up-to-7 criteria, we used Modified Bolondi’s Subclassification (Kinki Criteria), to sub-classifies the BCLC B stage into B1/B2/B3 subcategories. Radiofrequency ablation was done in the interventional ultrasound unit. Treatment efficacy was assessed 6 months after tumor ablation.

Results

One hundred twenty participants were enrolled in our research trial, 72 (60%) were within the intermediate stage, and 48 (40%) had early-stage HCC. Most of our patients were males, 78 (65%). All the early-stage-HCC patients were Child–Pugh Score A (n = 48), while the intermediate-stage (BCLC B) group was classified in both Child–Pugh Score A (n = 59) and B (n = 16). Within the intermediate group (BCLC-stage B), All enrolled cases fell within category “B1” within the Kinki Criteria. Logistic regression analysis illustrated that the pre-treatment level of Platelet count and post-treatment level of AFP shows a statistically significant prediction effect on treatment response rate with p-value (0.028 and 0.007 respectively).

Conclusion

percutaneous radiofrequency ablation is considered an effective treatment option for the B1 subcategory according to Kinki Criteria for intermediate-stage HCC (BCLC-B1) but long-term follow-up is recommended.
Innovative Glucagon-based Therapies for Obesity
Authors: Enyew Belay Kibret , Jemal Rebil Heiru , Tuyizere Aloys
Published: November 2024

Obesity poses a significant global health challenge, with an alarming rise in prevalence rates. Traditional interventions, including lifestyle modifications, often fall short of achieving sustainable weight loss, ultimately leading to surgical interventions, which carry a significant burden and side effects. This necessitates the exploration of effective and relatively tolerable pharmacological alternatives. Among emerging therapeutic avenues, glucagon-based treatments have garnered attention for their potential to modulate metabolic pathways and regulate appetite. This paper discusses current research on the physiological mechanisms underlying obesity and the role of glucagon in energy homeostasis. Glucagon, traditionally recognized for its glycemic control functions, has emerged as a promising target for obesity management due to its multifaceted effects on metabolism, appetite regulation, and energy expenditure. This review focuses on the pharmacological landscape, encompassing single and dual agonist therapies targeting glucagon receptors (GcgRs), glucagon-like peptide-1 receptors (GLP-1Rs), glucose-dependent insulinotropic polypeptide receptors (GIPRs), amylin, triiodothyronine, fibroblast growth factor 21, and peptide tyrosine tyrosine. Moreover, novel triple-agonist therapies that simultaneously target GLP-1R, GIPR, and GcgR show promise in augmenting further metabolic benefits. This review paper tries to summarize key findings from preclinical and clinical studies, elucidating the mechanisms of action, safety profiles, and therapeutic potential of glucagon-based therapies in combating obesity and its comorbidities. Additionally, it explores ongoing research endeavors, including phase III trials, aimed at further validating the efficacy and safety of these innovative treatment modalities.
A Sociocognitive Grading Model for First-Year Writing Classes
Authors: Nastal Jessica
Published: November 2024

This article offers a theory of action model for grading in first-year writing classes, as enacted at two public, suburban, Midwestern two-year colleges. First, it analyzes labor-based contract grading and specifications grading through this model, examining how these popular grading methods have manifested in unintended negative consequences for historically and multiply marginalized students. Then, it proposes a sociocognitive grading model designed to maximize course-level success rates for New Majority college students. The sociocognitive model was iteratively built on feminist standpoint theory, intersectional learning sciences, multilingual writing pedagogy, and disability studies. Thus far, student course-level success has improved, along with their learning in four domains of a robust writing construct: intrapersonal, interpersonal, cognitive, and health. While it does not prescribe specific patterns of response, this model nevertheless establishes an overall referential frame that holds the potential to incorporate empirically based best response practices.
Exercise-Based Telerehabilitation for Heart Failure Patients Declining Outpatient Rehabilitation—A Randomized Controlled Trial
Authors: LUNDGREN KARI MARGRETHE , LANGLO KNUT ASBJØRN RISE , SALVESEN ØYVIND , ASPVIK NILS PETTER , MO RUNE , ELLINGSEN ØYVIND , VESTERBEKKMO ELISABETH , ZANABONI PAOLO , DALEN HÅVARD , AKSETØY INGER-LISE AAMOT
Published: November 2024

Purpose

Cardiac rehabilitation participation rates are low despite strong recommendations, and many chronic heart failure patients remain physically inactive. Rural living, long travel distance, costs, age, and frailty might be factors explaining this. To increase cardiac rehabilitation uptake, we designed an exercise-based randomized controlled telerehabilitation trial enabling chronic heart failure patients unable or unwilling to participate in outpatient cardiac rehabilitation to exercise at home. Aim was to evaluate the long-term effects of telerehabilitation on physical activity levels.

Methods and results

Chronic heart failure patients (n = 61) with reduced (≤40%), mildly reduced (41%–49%), or preserved ejection fraction (≥50%) were randomized (1:1) to telerehabilitation (n = 31) with an initial 3-month group-based high-intensity exercise telerehabilitation program or control (n = 30), with regular follow-up visits over a 2-yr period. All participants attended a “Living with heart failure” course. Outcomes were measures of physical activity, peak oxygen uptake, 6-min walk test distance, quality of life, morbidity, and mortality. We found no significant differences between groups for long-term changes in moderate to vigorous activity (MVPA) or peak oxygen uptake from baseline to the 2-yr follow-up. Nor quality of life differed between groups, but both groups had significant within-group improvements in score on the Minnesota Living with Heart Failure Questionnaire (P = 0.000) and improvement in EQ-5D visual analog scale score was significant (P = 0.05) in the telerehabilitation group.

Conclusions

Telerehabilitation performed as home-based real-time high-intensity exercise sessions provided by videoconferencing for participants unable or unwilling to participate in standard outpatient cardiac rehabilitation did not affect long-term physical activity levels or physical capacity as expected. Still, a positive effect on health-related quality of life was seen in both groups.
Retrospectives: Friedman and Schwartz, Disaggregated
Authors: Burns Jennifer
Published: November 2024

What was the contribution of Anna Schwartz to the landmark book she co-authored with Milton Friedman, A Monetary History of the United States, 1867-1960? A close examination of archival evidence suggests three primary contributions Schwartz made to the work, and to Friedman’s career more generally. The first was meeting the classic challenge of quantitative economic history: going into the field to locate and collect archival data that had been assembled for purposes unrelated to economic research, and deciding how best to use that data. Second, Schwartz had a decades-long role as technical sounding board and shaper of the statistical approach taken in the book. Schwartz’s third and arguably greatest contribution was to transform A Monetary History of the United States into a compelling narrative argument that made an impact far beyond the economics profession. Together, these findings show Schwartz to be a scholar who made significant and lasting contributions to monetary economics, economic history, and the broader field of economics.
The Political Economy of Industrial Policy
Authors: Juhász Réka , Lane Nathan
Published: November 2024

We examine the ways in which political realities shape industrial policy through the lens of modern political economy. We consider two broad “governance constraints”: (1) the political forces that shape how industrial policy is chosen and (2) the ways in which state capacity affects implementation. The framework of modern political economy suggests that government failure is not a necessary feature of industrial policy; rather, it is more likely to fail when countries pursue industrial policies beyond their governance capacity constraints. As such, our political economy of industrial policy is not fatalist. Instead, it enables policymakers to constructively confront challenges.
Αριθμητική προσομοίωση της εργαστηριακής κοπής πετρωμάτων με μηχανικά μέσα
Authors: Καλογερόπουλος Αντώνιος
Published: November 2024

Στην παρούσα διατριβή, η Μέθοδος Διακριτών Στοιχείων (DEM) χρησιμοποιήθηκε για την προσομοίωση της εργαστηριακής κοπής πετρωμάτων με κοπτικό συρόμενου τύπου. Η ρεαλιστική αναπαράσταση της δύναμης κοπής στο φάσμα του χρόνου καθώς και του μηχανισμού αστοχίας που παρατηρήθηκαν από τις εργαστηριακές δοκιμές μεταφράστηκε ως ένα πρόβλημα επιλογής κατάλληλων τιμών των μικροπαραμέτρων. Πιο συγκεκριμένα προτάθηκε μια μέθοδος βαθμονόμησης χρησιμοποιώντας τις αρχές του Σχεδιασμού Πειραμάτων (DOE) και τεχνικές βελτιστοποίησης. Χρησιμοποιώντας τις μεθόδους Plackett-Burman και Κεντρικού Σύνθετου Σχεδιασμού (ΚΣΣ), προέκυψαν εξισώσεις που συνδέουν τα μικροπαραμέτρους με τις μέσες δυνάμεις κοπής, και προσδιορίστηκε ένα βέλτιστο σύνολο μικροπαραμέτρων με τη χρήση της μεθόδου Βελτιστοποίησης Διαδοχικών Τετραγώνων (SLSQP). Η μελέτη αποκάλυψε ότι οι μικροπαράμετροι, και ιδιαίτερα ο συντελεστής εύρους αλληλεπίδρασης, επηρεάζουν σημαντικά την ιστορία των δυνάμεων κοπής και τους μηχανισμούς θραύσης. Η μακροσκοπική απόκριση του πλήρως βαθμονομημένου αριθμητικού μοντέλου αξιολογήθηκε τόσο ποιοτικά όσο και ποσοτικά σε όρους λόγου της ΜΔΚ από την προσομοίωση προς την πραγματική ΜΔΚ από εργαστηριακές δοκιμές. Τα αποτελέσματα έδειξαν ότι η δύναμη κοπής από την προσομοίωση ταυτίζεται ποιοτικά με την πραγματική δύναμη κοπής της δοκιμής, και την προσεγγίζει με μέση απόκλιση της τάξης του 3%. Μέσα από την παρούσα έρευνα αναπτύχθηκε ένα πρωτόκολλο βαθμονόμησης των μικροπαραμέτρων για την επίτευξη ρεαλιστικής προσομοίωσης της κοπής. Εκτελέστηκε πλήρης διερεύνηση του περιβάλλοντος προσομοίωσης στον ρεαλισμό της κοπής πετρωμάτων. Τα αποτελέσματα αξιολογήθηκαν όχι μόνο ως προς τη Μέση Δύναμη Κοπής, αλλά στο πλήρες πεδίο του χρόνου και στο φάσμα συχνοτήτων. Ο συντελεστής εύρους αλληλεπίδρασης μπορεί να μοντελοποιήσει την μικροδομή των πετρωμάτων και να αναδείξει τον πραγματικό μηχανισμό αστοχίας και της δημιουργίας θραυσμάτων που συμβαίνουν κατά την κοπή.
Η ελληνόγλωσση εκπαίδευση στην Αλβανία και οι διαδικασίες λήψης αποφάσεων
Authors: Σωτηρούδας Βασίλειος
Published: November 2024

Η ελληνόγλωσση εκπαίδευση στην Αλβανία συνιστά ένα ψηφιδωτό όπου οι διάφοροι φορείς που εμπλέκονται αποτελούν τις επιμέρους ψηφίδες. Στην παρούσα μελέτη καταγράφεται η υπάρχουσα κατάσταση και αναλύεται η διαδικασία λήψης των σχετικών αποφάσεων. Επιπλέον, διερευνώνται τα υφιστάμενα προβλήματα και αποτυπώνονται συνολικά οι προοπτικές της ελληνόγλωσσης εκπαίδευσης στην Αλβανία. Προκειμένου να επιτευχθούν ο σκοπός και οι επιμέρους στόχοι της έρευνας, ακολουθήθηκε μία σύνθετη ερευνητική στρατηγική, που περιλαμβάνει δύο ξεχωριστές μεθοδολογίες έρευνας, την αρχειακή έρευνα και την εμπειρική έρευνα. Η εμπειρική έρευνα με τη σειρά της, αποτελεί ένα συνδυασμό ποιοτικής και ποσοτικής προσέγγισης στη συλλογή των ερευνητικών δεδομένων, με χρήση ερωτηματολογίου και διεξαγωγή συνεντεύξεων. Το μεγαλύτερο μέρος της αρχειακής έρευνας που πραγματοποιήθηκε περιλαμβάνει υπηρεσιακά έγγραφα και νομοθεσία. Για την ανάλυση των δεδομένων του ερωτηματολογίου, χρησιμοποιήθηκε περιγραφική και συμπερασματική (επαγωγική) στατιστική, ενώ για την ανάλυση των δεδομένων των συνεντεύξεων πραγματοποιήθηκε θεματική ανάλυση περιεχομένου. Από τα πορίσματα της έρευνας προκύπτει ότι η ελληνόγλωσση εκπαίδευση στην Αλβανία συνιστά μία δαιδαλώδη κατάσταση, με πολλούς εμπλεκόμενους φορείς διαφορετικής προέλευσης και στρατηγικής. Το θεσμικό πλαίσιο, παρά τις αλλεπάλληλες αλλαγές που έχει υποστεί τα τελευταία πενήντα χρόνια, κάθε άλλο παρά κατάφερε να επιλύσει τα αναφυόμενα προβλήματα. Τα προβλήματα που αντιμετωπίζουν τόσο οι εκπαιδευτικές μονάδες παροχής ελληνόγλωσσης εκπαίδευσης, όσο και οι εμπλεκόμενοι εκπαιδευτικοί, είναι πολυποίκιλα και οφείλονται σε αμφότερες την ελληνική και αλβανική πλευρά. Η προοπτική της ελληνόγλωσσης εκπαίδευσης στην Αλβανία δεν καταγράφεται αισιόδοξη, καθώς η επίλυση των προβλημάτων που εντοπίζονται απαιτεί πολύπλευρη παρέμβαση και στοχευμένη στρατηγική, που δεν είναι καθόλου βέβαιο ότι υπάρχει περίπτωση να σημειωθούν στο άμεσο μέλλον. Ωστόσο, η ύπαρξη μίας ζωντανής κοιτίδας ελληνισμού στη γειτονική χώρα, καθώς και η διάθεση που επιδεικνύουν ακόμα, εκπαιδευτικοί και φορείς στην ημεδαπή και στην Αλβανία να ασχοληθούν με την εκπαίδευση στη μητρική γλώσσα, αφήνει κάποια περιθώρια αισιοδοξίας και μπορούν να αποτελέσουν τη βάση για να στηριχτεί οποιαδήποτε μελλοντική προσπάθεια για την ενίσχυση και βελτίωση της ελληνόγλωσσης εκπαίδευσης συνολικά στην Αλβανία.
Δραστηριότητες κινητικής αναψυχής για ολιστική ευεξία και επιτυχή γήρανση σε άτομα με σύνδρομο Down και τους φροντιστές τους
Authors: Μάντσος Ευάγγελος
Published: November 2024

Η παρούσα διατριβή στοχεύει στη μελέτη της σχέσης της Φυσικής Δραστηριότητας με την επιτυχή γήρανση των ατόμων με σύνδρομο Down και των φροντιστών τους. Πιο συγκεκριμένα, μελετήθηκε αν και πώς παρέμβαση με Φυσική Δραστηριότητα επηρεάζει τα βασικά συστατικά της επιτυχούς γήρανσης, δηλαδή την ευεξία, την ικανοποίηση από τη ζωή και την ποιότητα ζωής στα άτομα με σύνδρομο Down. Μελετήθηκε, ακόμη, αν η βελτίωση των παραπάνω παραγόντων έχουν αντίκτυπο και στους φροντιστές τους. Συνολικά, πραγματοποιήθηκαν τέσσερις μελέτες. Στην πρώτη μελέτη έγινε προσαρμογή του ερωτηματολογίου Body Mind Spirit Wellness Behavior and Characteristic Inventory (BMS- WBCI) στα ελληνικά, με 643 συμμετέχοντες. Η ελληνική έκδοση του ερωτηματολογίου αποτελείται από 38 δηλώσεις, αντί για 44 της αρχικής. Βρέθηκε πολύ καλή εσωτερική συνέπεια (Σώμα 0.86, Νους 0.95, Πνεύμα 0.94) και καλή συγκλίνουσα εγκυρότητα (Σώμα 50,5%, Νους 50,7%, Πνεύμα 54,9%). Στη δεύτερη μελέτη πραγματοποιήθηκε παρέμβαση 12 εβδομάδων με Φυσική Δραστηριότητα που αποσκοπούσε στη βελτίωση των παραμέτρων της ευεξίας όπως ορίζονται από το Μοντέλο των Έξι Διαστάσεων του Hettler (1984). Στην έρευνα συμμετείχαν 31 άτομα με σύνδρομο Down, 17 άνδρες και 14 γυναίκες (36+9.23) ετών. Από τα αποτελέσματα φάνηκε στατιστικά σημαντική βελτίωση όλων των παραμέτρων της ευεξίας (p< .001), της ικανοποίησης από τη ζωής (p< .001) αλλά και του σκορ στο SO fitness (p< .01). Η τρίτη μελέτη αποσκοπούσε στη μελέτη της ευεξίας, της ικανοποίησης από τη ζωή και της ποιότητας ζωής των φροντιστών των ατόμων με σύνδρομο Down. Οι συμμετέχοντες αυτής της μελέτης ήταν 31 (62.77+9.64 ετών), δηλαδή, ένας φροντιστής για κάθε άτομο με σύνδρομο Down. Από τα αποτελέσματα φάνηκε ότι η βελτίωση μετά την παρέμβαση στα άτομα με σύνδρομο Down συνδεόταν με βελτιώσεις σε όλους τους παράγοντες της ευεξίας (p< .001) και την ικανοποίηση από τη ζωή (p< .001) των φροντιστών. Αλλά και η ποιότητα ζωής των φροντιστών βελτιώθηκε στον ψυχολογικό τομέα, στον τομέα των κοινωνικών σχέσεων και στον τομέα του περιβάλλοντος (p< .01). Στη τέταρτη μελέτη 10 από τους φροντιστές της μελέτης 3 συμμετείχαν σε δομημένη συνέντευξη σχετικά με το πρόγραμμα παρέμβασης (μελέτη 2) στα άτομα με σύνδρομο Down. Σύμφωνα με τις απαντήσεις τους, το πρόγραμμα παρέμβασης επηρέασε θετικά την ευεξία των ατόμων αυτών και την υλοποίησή του με ασφάλεια, προωθώντας την ψυχική, κοινωνική και σωματική τους υγεία. Από τις παραπάνω μελέτες φαίνεται ότι ένα πρόγραμμα παρέμβασης με δραστηριότητες αναψυχής σε αθλητικούς χώρους, σε αίθουσα αλλά και στην ύπαιθρο μπορεί να βελτιώσει σημαντικά τους παράγοντες που συμβάλλουν στην επιτυχή γήρανση των ενηλίκων ατόμων με σύνδρομο Down. Επιπλέον, οι βελτιώσεις αυτές επηρεάζουν την επιτυχή γήρανση και την ποιότητα ζωής των φροντιστών τους.
The genome sequence of the Common Wainscot moth, Mythimna pallens Linnaeus, 1758
Authors: Holt Stephanie , Sivess Laura , Januszczak Inez , Broad Gavin R. , Fletcher Chris ,   Natural History Museum Genome Acquisition Lab,   Darwin Tree of Life Barcoding collective,   Wellcome Sanger Institute Tree of Life Management, Samples and Laboratory team,   Wellcome Sanger Institute Scientific Operations: Sequencing Operations,   Wellcome Sanger Institute Tree of Life Core Informatics team,   Tree of Life Core Informatics collective,   Darwin Tree of Life Consortium
Published: November 2024

We present a genome assembly from an individual male Mythimna pallens (the Common Wainscot moth; Arthropoda; Insecta; Lepidoptera; Noctuidae). The genome sequence has a total length of 719.10 megabases. Most of the assembly is scaffolded into 31 chromosomal pseudomolecules, including the Z sex chromosome. The mitochondrial genome has also been assembled and is 15.33 kilobases in length. Gene annotation of this assembly on Ensembl identified 18,343 protein-coding genes.
Analysis of the financial and economic activities of the enterprise
Authors: Chernysheva Yuliya , Udalova Zoya , Goncharova Lyudmila , Radchenko Yuliya , Sklyarova Oksana , Blokhina Viktoriya , Guzey Viktoriya , Usenko Lyudmila
Published: November 2024

The textbook reveals the basic concepts of analyzing the financial and economic activities of an organization. The historical and theoretical aspects of economic analysis, methodological tools of economic analysis, methods of financial analysis, fundamental aspects of managing the use of organizational resources and cost of production, investment, functional and cost, strategic, marketing analysis, analysis of financial markets, issues of methodology for analyzing innovative activity of organizations are considered.
Meets the requirements of the federal state educational standards of higher education of the latest generation.
For students studying in the field of 38.03.01 "Economics", students of the system of continuing professional education.
Management in the organization of children's recreation and their recovery
Authors: Kulachenko Marina
Published: November 2024

The textbook discusses the main issues of training managerial personnel capable of organizing children's leisure, solving specific practical management tasks in organizations of the field of recreation and recreation for children. The theoretical material is valuable in improving the professional competencies of the heads of organizations for children's recreation and their health improvement and provides comprehensive preparation for solving the tasks facing the leadership of an organization that educates a child in leisure conditions.
Meets the requirements of the federal state educational standards of higher education of the latest generation.
It is intended for students of the master's degree of higher educational institutions studying under the USGS 44.00.00 "Education and pedagogical sciences", students of advanced training courses on the organization of children's leisure during the holidays.
Organization, rationing and remuneration of labor in the food industry
Authors: Pechenaya Lyudmila , Astrahanceva Elena , Domarev Ivan , Ziyakaev Radik
Published: November 2024

The textbook outlines the theoretical foundations of the organization of labor; it considers: methods of studying labor processes as the basis of organization, rationing and remuneration; the essence of labor rationing and its importance for food industry enterprises; labor rationing in various fields of enterprise activity; rationing of managerial labor (employee labor), development of rest time standards; organization of remuneration for different categories of workers; efficiency and effectiveness of labor.
A special place in the textbook is given to the development of scientifically based labor standards, the implementation of wage calculations in the application of various wage systems, as well as practical recommendations on the use of a system of labor standards, improving labor efficiency and productivity.
Meets the requirements of the federal state educational standards of higher education of the latest generation.
For undergraduate students studying in the field of Economics. Familiarization with this textbook will be useful for future masters, graduate students and specialists of food industry enterprises.
Record keeping and archival business
Authors: Zayceva Ekaterina , Goncharova Natal'ya
Published: November 2024

The proposed textbook covers topics related to the documentation support of management and archival business — issues of the history of the development of record keeping and archival business in the Russian Federation, documentation technology, preparation of documents for operational and archival storage. The textbook can be used in the educational process, as well as serve as a reference guide for organizing the work of the documentation support service of management in an organization, institution, authority.
Meets the requirements of the federal state educational standards of higher education of the latest generation.
For students of higher educational institutions studying in the field of training "Management".
Using Multimodal Texts to Develop Chinese Students' Communication Skills in Russian
Authors: Sotova Irina , Jin Ling
Published: November 2024

Introduction. In the context of the development of cooperation between Russia and China, the importance of communication as a means of interethnic, intercultural and interpersonal communication is increasing. The search and creation of didactic tools for the more successful development of Chinese students' speaking skills in Russian, which are communicatively significant and difficult to master, are urgent tasks.

The purpose of this article is to describe the extralinguistic causes of difficulties in developing the Russian speaking skills of Chinese students and to reveal the linguodidactic potential of multimodal texts for teaching speaking in Russian.

Research methods include theoretical analysis, pedagogical observation and generalization of pedagogical experience.

Results. The authors of the article identify as extralinguistic reasons for difficulties in developing skills among Chinese students: the isolation of textbooks from modern communication practice, a limited number of classroom hours, the written form of passing exams in Russian at Chinese universities, excessive dependence of students on translation programs and low motivation to speak. The authors conclude that the use of multimodal texts motivate students to speak in Russian by mobilizing various channels of information, topical issues, background information about Russian culture and creating a more relaxed and natural atmosphere in the classroom. Scientific novelty. The linguodidactic potential of using multimodal texts for the development of speaking skills is revealed.

Practical significance. The use of multimodal texts will help the teacher to improve the level of Russian speaking skills of Chinese students, especially in the absence of a language environment.
Russian as a Foreign Language Textbook of Business (Professional) Communication: Modelling Principles
Authors: Bozhenkova N. , Semke T.
Published: November 2024

In the conditions of the new government demand for training foreign specialists of various profiles in Russian higher education, the task of optimising the existing educational paradigm in the field of teaching Russian as a foreign language for special purposes is actualised, the most important link of which is the methodological goal set for the formation of the learners' (foreign or Russian universities’ students) ability to overcome the ideological threshold in professional interethnic (intercultural) communication.

The analysis of research and methodological literature gives grounds to assert that Russian linguodidactics is ready to ensure the convergence of the pedagogical process, in which formal language teaching, professional training and education in line with the Russian culture and value paradigm can be presented syncretically within the framework of problem-based and / or interactive approaches in one (unified) teaching tool — a textbook / workbook / training manual / training course / educational-methodical complex. As one of the possible strategies for a comprehensive solution to the problem of compliance of educational resources with the latest social challenges, the potential of a new method of creating teaching tools — the method of casual illustrated narrative (CIN), which provides synergetic presentation of the language and culture of business (professional) communication in the framework of the scenario form and thus determines the possibility of building a model of the space-time continuum of professional communication, is substantiated.

As a proof of the success and practical significance of the proposed strategy — the SIN method — we present the online course "Russian for Life and Work" developed in 2024 for migrant workers from CIS countries (SPbU, Uzbek national version), the results of the approbation of which led the Russian government to instruct a number of Russian universities to create additional national versions.
Educational technologies as a key component of pedagogical communication
Authors: Goncharova Lyubov
Published: November 2024

The words of the editor-in-chief indicate the key scientific aspects of the publications in the current issue and note the relevance of research into communicative practices carried out in various spheres of human activity.
Characteristics of Modern Russian Advertising Technical Discourse
Authors: Yuy Hunbo , Boguslavskaya Vera
Published: November 2024

This article is devoted to the analysis of the Russian advertising technical discourse. The subject of the article is the sociolinguistic features of the Russian advertising technical discourse on the example of electronic technical advertising in 2024, addressed to a mass audience.

Materials and methods. The empirical material was electronic advertising messages created to promote high-tech products in Yandex in 2024. The sample size for the article was 146 texts of technical advertising. Interpretive analysis and the method of content analysis were used in the analysis of the material.

Results. The results of the study showed that, taken together, the characteristics of the RATD are multifaceted: there is not only reflects confidence in technical achievements and professionalism, but also unites there is an emphasis on urgency, safety and creativity, as well as on the orientation on national culture and spiritual and cultural values. The RATD also demonstrates a new feature of modern technical advertising - interactivity. Together, these elements have formed a unique style of RATD. The results of the research can be used in practical work by advertising specialists promoting technical and high-tech products on the Russian market; in lecture courses on technical discourse and advertising discourse.
Investigations of the vascular endothelial factor levels’ changes in experimental diabetic retinopathy
Authors: Preys Nataliya , Savytskyi Ivan
Published: November 2024

Introduction: The paper presents the results of the vascular endothelial growth factor of rats with experimental diabetic retinopathy (DR).
Material and methods: Experimental studies were performed on white Wistar rats, which were divided into 7 groups: 1st group – intact animals; 2nd group – 60 animals with modelling of DR without correction (control pathology); 3rd group –60 animals with modelling of DR with correction of hyperglycemia; 4th group – 60 animals with modelling of DR with correction of hyperglycemia, administration of aflibercept and L-arginine solution; 5th group – 60 animals with modelling of DR with correction of hyperglycemia, administration of aflibercept and bromfenak; 6th group – 60 animals with modelling of DR with correction of hyperglycemia, administration of aflibercept, L-carnitine solution and bromfenak; 7th group – 60 animals with modelling of DR with correction of hyperglycemia, administration of aflibercept, L-arginine solution and citicoline.
Results: The results of the analysis of the VEGF in the 2nd group confirm the development of DR, a particularly pronounced increase in the marker was detected on the 180th day of the development of the pathological process. The results of the 4th group indicate that the involvement of a nitric oxide donor and aflibercept in the correction of DR has positive effect on the reduction of the VEGF level, more pronounced compared to the 3rd group, but it does not reach normative values. It is observed that the correction of the simulated pathological condition by reducing hyperglycemia, administration of aflibercept and bromfenac (group No. 5) gives positive results, but less pronounced, compared to the data of the 4th group. It was found that in rats with DR with subsequent correction of hyperglycemia, administration of aflibercept, L-carnitine and bromfenac (group No. 6) at the first stage, there is a pronounced effectiveness of the proposed method of correction in comparison with the previously considered methods. The most pronounced positive effect of normalizing the VEGF level is observed when using a hypoglycemic drug in combination with the administration of aflibercept, a solution of L-arginine and citicoline (group No. 7).
Conclusions: The obtained data confirm the development of diabetic retinopathy, a particularly marked increase in the marker was detected on the 180th day of the development of the pathological process (p<0.001). Aflibercept has a positive effect on the normalization of this condition, but a more pronounced effect is observed in combination with long-term administration of L-arginine. The relationship between the normalization of the vascular growth factor and the correction of hypoxia was also revealed.
Academic discipline „Travel services market” in the digital age
Authors: Binytska Olena
Published: November 2024

The article discusses the possibility of using digital technologies in teaching the discipline ‘Market of tourist services. It is emphasised that digitalisation of education is a prerequisite for the training of competitive specialists in the tourism industry. The introduction of innovative technologies, such as artificial intelligence capabilities, immersive technologies, and large data sets, are changing approaches to teaching professional disciplines, providing students of the speciality ‘Tourism’ with opportunities for the development of professional skills. The article also analyses how to use online platforms, social media and content marketing when studying the course ‘market of tourist services’.
Thus, the article emphasises the importance of digital transformation in education and tourism business, which contributes to better training of competitive professionals and meeting the needs of modern consumers in the tourism industry.
The essence and content of scientific research methodology
Authors: Mozolev O. , Polishchuk O.
Published: November 2024

The article analyzes the essence and content of the concepts "methodology", "methods of scientific research". The content of general and special methods of conducting scientific research is disclosed. It has been established that the methodology of scientific research is a conceptual statement of the content, purpose, and methods of research that allow obtaining the most objective, systematized and accurate information about phenomena and processes. The methodology systematizes the methods, methods and methods of learning objective reality, ensuring the reliability of the obtained knowledge about the object of research, their compliance with the subject of research, and is also a means of substantiating the results and conclusions of the conducted scientific research.
The methods of scientific research mean a set of cognitive rules and techniques, implemented in the form of interconnected operations, designed to obtain new knowledge, consisting of three stages: research, proof and explanation. Methods are a set of techniques and methods of activity that allow a person or organization to achieve set goals. The choice of methods depends on the nature and content of the problem, the terms and resources allocated for its study, the amount and quality of available information. The authors characterized the content of empirical, theoretical and special methods of scientific research. It has been established that general scientific methods provide an opportunity in the process of scientific research to determine only general approaches to the defined scientific problem. Special methods allow obtaining specific knowledge, answers to questions from the subject area of research.
Dzielnica VII Zwierzyniec: Historia - ludzie - kultura
Authors: Trzeskowska-Kubasik Karolina
Published: November 2024

DISTRICT VII ZWIERZYNIEC: HISTORY – PEOPLE – CULTURE The structure and urban layout of Krakow is the result of centuries of evolution, and the current territory of the city includes not only the former, so-called "Sarmatian Tri-City" or even "Penta-City" but also the entire mosaic of jurydyki and villages surrounding it in the past, constituting to a large extent a single economic space. Some of them - Zwierzyniec with Salwator, Półwsie Zwierzynieckie together with Błonia, Chełm and Zakamycze, Przegorzały, Wola Justowska with Wolski Forest, Bielany and Olszanica - currently from District VII of Krakow. Its past is inextricably linked with the history of the inhabitants of the former villages, subjects to various superior authorities - monastic, clerical, noble, royal and municipal. The book was written by historians, regionalists and archeologists associated with and originating from the Krakow scientific community. The aim of it is to present the prehistory and history of the area that is currently District VII Zwierzyniec. The time frame of the study is wide and covers the period from prehistory to the preesent day. It is worth nothing that this is the first attempt so far to comprehensively discuss the history of a modern district of Krakow in a monographic outline and present its multi-threaded history, including such issues as its changing limits, administrative, settlement, economic, social, communication, educational and cultural developments, and dozens of others.
Reconfiguración espacial en el Aburrá Sur: desconcentración concentrada y tensiones en el modelo de ciudad
Authors: Vélez Villegas Santiago
Published: November 2024

El Aburrá Sur ha experimentado un acelerado desarrollo inmobiliario en las últimas dos décadas, que se suma a una relocalización creciente de actividades de servicios y de población hacia su territorio, y a una desconcentración de funciones de dirección económica y política hacia Medellín. Un resultado observable es la contradicción entre el modelo de ordenamiento metropolitano orientado al redesarrollo y las dinámicas expansivas del circuito financiero-inmobiliario. Se busca resaltar la importancia del Aburrá Sur en la reconfiguración socioespacial de la región metropolitana y los impactos diferenciales del proceso de expansión urbana a lo largo del Va-lle. La contradicción entre el modelo de ciudad compacta predicado por las autoridades de planeación y la realidad de una creciente expansión urbana es síntoma de un reescalamiento del proceso de urbanización metropolitano en el que se articulan poderes globales, regionales y locales, combinando instrumentos de ordenamiento, políticas económicas y dispositivos ideológicos de la planeación urbana.
On the Impossibility of Convergence of Mixed Strategies with Optimal No-Regret Learning
Authors: Muthukumar Vidya , Phade Soham , Sahai Anant
Published: November 2024

We study the limiting behavior of the mixed strategies that result from optimal no-regret learning in a repeated game setting where the stage game is any 2 × 2 competitive game. We consider optimal no-regret algorithms that are mean-based and monotonic in their argument. We show that for any such algorithm, the limiting mixed strategies of the players cannot converge almost surely to any Nash equilibrium. This negative result is also shown to hold under a broad relaxation of these assumptions, including popular variants of Follow-the-Regularized Leader with optimism or adaptive step sizes. Finally, we provide partial evidence that the monotonicity and mean-based assumptions can be removed or relaxed. Our results identify the inherent stochasticity in players’ realizations as a critical factor underlying this divergence, and demonstrate a crucial difference in outcomes between using the opponent’s mixtures and realizations to make updates.

Funding: V. Muthukumar was supported by a Simons-Berkeley Research Fellowship, NSF awards IIS-2212182 and CCF-2239151, and generous gifts from Amazon, Adobe, and Google. S. Phade acknowledges the support of the NSF [Grants CNS-1527846 and CCF-1618145] and the NSF Science & Technology Center [Grant CCF-0939370 (Science of Information)]. A. Sahai acknowledges the support of the ML4Wireless center member companies and the NSF [Grants AST-144078 and ECCS-1343398].
TECNOLOGIAS DIGITAIS DA INFORMAÇÃO E COMUNICAÇÃO (TDIC) UTILIZADAS POR PROFESSORES DE CIÊNCIAS E BIOLOGIA
Authors: Schneider Eduarda , Nunes Silvana Aguero , Kaizer Amanda Camila
Published: November 2024

O presente estudo objetiva investigar quais Tecnologias Digitais da Informação e Comunicação (TDIC) foram utilizadas no ensino remoto emergencial, evidenciando as dificuldades e vantagens encontradas. A metodologia de pesquisa, de abordagem qualitativa, consistiu em uma entrevista semiestruturada realizada com professores de Ciências e Biologia participantes do projeto Residência Pedagógica. Os dados levantados foram organizados e analisados seguindo os pressupostos da análise de conteúdo. Os resultados apontaram que os docentes embora já tenham ouvido falar das TDIC ou TIC, ainda encontram dificuldades ao conceituar estes termos. Com relação as TDIC mais utilizadas durante o ensino remoto, o Whatsapp, Facebook, Google Meet e Classroom foram as mais utilizadas. Quanto as dificuldades a respeito do uso das TDIC, os docentes citam principalmente a falta de conhecimento e de formação específica sobre o tema e, a falta de acesso dos alunos a tecnologia. Sobre às vantagens que as TDIC proporcionaram, os professores citam o acesso rápido a informação, aulas mais dinâmicas e interativas e a aceleração do processo de informatização das escolas. Diante dos resultados da pesquisa é possível inferir que, apesar das dificuldades em inserir as TDIC em sala de aula, elas podem contribuir com o processo de ensino e aprendizagem, sendo assim importante continuar as pesquisas sobre o que as TDIC têm a oferecer ao contexto educacional