bluuebunny/crossref_metadata_2025 huggingface dataset:
Psicanálise e psicoterapia psicanalítica: tangências e superposições
Authors: Silva Milena da Rosa , Gasparetto Letícia , Mengden Campezatto Paula von
Published: August 2020

Este trabalho busca apresentar, através de uma revisão da literatura, um panorama dos trabalhos teóricos e empíricos

que buscam definir as características da psicoterapia psicanalítica e suas possíveis diferenças em comparação ao

tratamento psicanalítico propriamente dito. Constatou-se que há autores que percebem psicanálise e psicoterapia

de orientação analítica como técnicas bastante similares, sendo difícil a distinção entre elas. Outros as vêem como

os pólos extremos de uma mesma abordagem, sendo possível oscilar de uma técnica a outra dentro de um mesmo

tratamento. E há ainda aqueles que as supõem essencialmente distintas, utilizando como critérios para diferenciação

entre as técnicas: fatores extrínsecos, como duração da sessão, freqüência e uso do divã; e/ou fatores intrínsecos,

como a centralidade da transferência, objetivos e indicação terapêutica. A partir deste trabalho, é possível perceber

quão complexo é este debate, não havendo consenso sobre os limites, pontos de divergência e convergência entre

essas práticas terapêuticas.

Palavras-chave: Psicanálise; Psicoterapia psicanalítica.
Prevención de la depresión y la ansiedad en estudiantes universitarios
Authors: Londoño Arredondo Nora Helena , Jaramillo Estrada Juan Carlos , Castaño Arroyave María Camila , Rivera Morales Diana Patricia , Rojas Zulma Berrio , Londoño Diana Correa
Published: August 2020

El objetivo de la investigación fue evaluar el impacto del programa de prevención para la depresión y la ansiedad

a través del desarrollo del pensamiento crítico y estrategias en solución de problemas en estudiantes universitarios

de primeros semestres. Método: se utilizó un diseño cuasi-experimental, evaluación pre-test y post-test, y grupo

control. Participaron 60 estudiantes de dos universidades de Colombia que cursaban su primer año de formación

(25% hombre y 75% mujeres), edad promedio 18.5 años; grupo experimental n=31, grupo control n=29. El programa

tuvo una duración de 10 sesiones. Los instrumentos utilizados fueron el CES-D (Rodloff y Locke, 1986), SCL-90

(Derogatis, 2002), el cuestionario de Acontecimientos estresantes (Connor-Smith y Calvete, 2004), ATQ (Kendall,

Howard y Hays, 1989), ASSQ (Kendall y Hollon, 1989). Resultados: se identificaron cambios significativos en

los indicadores clínicos de depresión, ansiedad, pensamientos negativos y valoración de acontecimientos vitales

en el grupo experimental. Conclusiones: el programa de prevención de la depresión y la ansiedad a través del

modelo del desarrollo del pensamiento crítico y el diálogo socrático, es efectivo en jóvenes universitarios del primer

año de formación, en la medida que disminuye significativamente los indicadores de depresión y ansiedad, los

pensamientos negativos y la valoración de los acontecimientos vitales.

Palabras-clave: Prevención; Depresión; Ansiedad; Pensamiento crítico; Diálogo socrático.
Dependência de exercício físico em atletas de endurance prolongada: corrida de aventura e triatletas
Authors: Gil de Oliveira Ana Lúcia , De Mello Marco Túlio , Tufik Sergio , M. Antunes Hanna Karen
Published: August 2020

A prática regular do exercício físico está associada com inúmeros benefícios a saúde, no entanto, quando esta

prática é excessiva, efeitos negativos psicológicos e fisiológicos são observados, contribuindo para gerar um quadro

de dependência de exercício. O objetivo do estudo foi verificar a existência ou não da dependência de exercício em

atletas de endurance prolongada (corrida de aventura e triatlo) investigando se existe correlação entre os escores da

escala de dependência de exercício e questionários de humor (POMS, IDATE) e se esta exerce alguma influência

na qualidade de vida (SF-36) dos atletas. Os resultados demonstraram que esses atletas apresentaram escores

indicativos de dependência de exercício, porém, sem influência significativa nos escores indicativos de distúrbios

de humor e com qualidade de vida superior a 85%. Isto sugere que, embora exista dependência de exercício, este

fato isolado não promove alterações significativas nos estados de humor e na qualidade de vida dos atletas.

Palavras-chave: Dependência de exercício; Atletas; Triatlo; Corrida de aventura; Humor.
Evaluación de parámetros de frescura en huevos de expendio comercial en la región de Junín
Authors: Lucas J. Raúl , Arana De la Cruz Carlos , Ramos Daphne
Published: August 2020

Los andes centrales del Perú requieren de intervenciones para garantizar la seguridad de super alimentos como el huevo pues la altitud de esta región no ha permitido el desarrollo de la producción avícola, por lo que la mayoría de los huevos son movilizados desde el nivel del mar lo que podría repercutir sobre la vida útil de este alimento. El objetivo del estudio fue el evaluar los parámetros de frescura de los huevos que se expenden en la sierra central del Perú. Para ello determinó la proporción de huevos que presentaban una frescura deteriorada a través del análisis de las unidades Haugh (UH), el índice de yema (IY) y el pH de la clara y yema en 145 huevos comerciales de las provincias de Jauja y Huancayo. El 13.8% de los huevos de tercera calidad presentaron simultáneamente todos los parámetros de frescura deteriorados por lo que superaban el tiempo de vida útil. Estos huevos estarían presentando una reducción de sus propiedades y, además, podrían ser más propensos a la invasión microbiana.
COMBINATION THERAPY OF MASSAGE AND TEMU IRENG HERBAL (Curcuma aeoruginosa Roxb.) TO INCREASE CHILD APPETITES AND FOOD INTAKE
Authors: Adianti Myrna , Pramesti Resti Ella , Puruhito Edith Frederika
Published: August 2020

Background: Appetite is a condition where a person has an urge to satisfy activities in eating. Lack of appetite in children is characterized by eating small portions, reluctant to refuse when it comes time to eat, take a long time to finish a meal, playing with the food, etc. Children are at the stage of high curiosity and very active, which mean the energy needed must be sufficient. If the energy and nutrition needs are not sufficient it might lead to a slowdown in physical and psychological growth. Purpose: The purpose of this case study is to observe whether Swedish massage and children’s massage with a combination of Temu Ireng herba (Curcuma aeruginosa Roxb.) could increase appetite in school-age children. Results: The results of massage therapy with Temu Ireng decotion can increase appetite in children based on the increasing number of calories consumed before therapy from 1,267 kcal to 2,050 kcal per day after therapy session, and an increase in body weight of 0.9 Kg after 8 weeks of therapy. Conclusion: Providing Swedish massage therapy with a combination of Temu Ireng herba (Curcuma aeruginosa Roxb.) could increase appetite in schoolage children with the result of increasing the number of daily calories intake and body weight.
ACUPUNCTURE AND SELF ACUPRESSURE TREATMENT OF HEMIFACIAL SPASM: A CASE REPORT
Authors: Septriana Maya , Perdana Yudi
Published: August 2020

Background: Hemifacial spasm (HFS) is a condition of unilateral, involuntary, irregular, spasmodic movements of the face. The condition is most commonly a result of vascular loop compression at the root entry zone of the facial nerve. Patient whose hemifacial spasm with  left-sided facial complaints often twitching since 6 months ago. This   69-year-old  man with hyperlipidemia and hypertension had diagnosed with hemifacial spasm by neurologist. Purpose: To prove the effect of acupuncture on Fengchi (GB 20), Neiguan (PC 6) and Taichong (LR 3) accompanied with acupressure on Taichong (LR 3)  and auricular acupressure on the Ear Shenmen point in patient with hemifacial spasm. Methods: Handling Hemifacial spasm with acupuncture on Fengchi (GB 20), Neiguan (PC 6) and Taichong (LR 3)  with the reducing method and strong stimulation three times a week, acupressure on the Taichong (LR 3) twice a day for 30 times pressure and auricular acupressure on ear Shenmen, twice a day for 5 minutes. Results: Biochemical  mechanism of acupuncture and acupressure involve the stimulation of acupoint that lead to complex neuro-hormonal response. In handling hemifacial spasm, acupunture given for 15 times, taken three times a week combined with acupressure and auricular acupressure. This therapy overcome the symptoms of facial twitching in hemifacial spasm. Conclusion: Acupuncture combined with acupressure and auricular acupressure can be used to overcome facial twitching in hemifacial spasm.
FORMULATION OF CREAM BODY SCRUB FROM ETHANOL EXTRACT OF CASSAVA LEAVES (Manihot esculenta) AS ANTIOXIDANT
Authors: Malik Fadhliyah , Suryani Suryani , Ihsan Sunandar , Meilany Elvianti , Hamsidi Rini
Published: August 2020

Background : Plant cassava leaves (Manihot esculenta) are known flavonoid is efficacious as antioxidant. Antioxidant can prevent damage to the skin by reducing free radical activity. Purpose : The purpose of this study to determine the concentration of ethanol extract of leaves of cassava can be formulated into dosage cream body scrub which have antioxidant activity. Method : Cassava leaf extract obtained by maceration using 97% ethanol. Determination of antioxidant activity by the method of reduction of free radical DPPH (1,1-diphenyl-2-picryl-hydrazyl). Result : The ethanol extract of cassava leaves are formulated into dosage cream body scrub with concentration variations 0,0085 mg/mL  (formula 1), 0,017 mg/mL  (formula 2), and 0,0255 mg/mL  (formula 3). Stability test preparation cream body scrub using cycling tests performed for 6 cycles. Preparation cream body scrub to formula I has a moderate antioxidant activity with IC50 158,16 µg/mL, formula 2 has an active antioxidant activity with IC50 66,59 µg/mL, and formula 3 has a stronger antioxidant activity with IC50 38,80 µg/mL. Conclusion : cream body scrub and cassava ethanol extract does not irritate so it is safe to use. Preparations cream body scrub well have the most activity at a concentration of 0,0255 mg/mL with IC50 38,80 µg/mL.
Faktor Kontekstual Pemanfaatan Pelayanan Antenatal Care di Indonesia
Authors: Puspitasari Dian Ayu , Samosir Omas Bulan
Published: August 2020

Tingkat kematian ibu yang tinggi seringkali dikaitkan dengan pemeriksaan kehamilan (antenatal care) yang tidak memadai. Pemanfaatan layanan ANC oleh wanita hamil di Indonesia menunjukkan variasi antar provinsi yang diduga dipengaruhi oleh faktor kontekstual yang melekat pada tiap-tiap provinsi. Penelitian ini bertujuan mempelajari faktor kontekstual pada level provinsi yang berhubungan dengan pemanfaatan pelayanan antenatal care pada level individu. Data Survei Demografi dan Kesehatan Indonesia tahun 2017 digunakan sebagai data pada level individu, sedangkan pada level kontekstual menggunakan data sekunder dari berbagai publikasi. Metode regresi logistik multilevel digunakan untuk menguji hipotesis bahwa faktor kontekstual pada level provinsi berhubungan dengan pemanfaatan layanan antenatal care pada level individu. Hasil penelitian ini menunjukkan bahwa selain faktor individu, faktor komunitas dimana individu tersebut tinggal juga berhubungan dengan perilaku ibu dalam memanfaatkan pelayanan antenatal care selama kehamilan. Konteks regional yang berhubungan kuat dengan pemanfaatan pelayanan antenatal care adalah persentase penduduk miskin di daerah tersebut. Tinggal di daerah yang tingkat kemiskinannya tinggi akan mengurangi kecenderungan wanita untuk melakukan pemeriksaan kehamilan. Oleh karena itu, untuk meningkatkan pemanfaatan pelayanan antenatal care serta mengurangi kesenjangan antardaerah, intervensi yang dapat dilakukan adalah dengan program pengurangan kemiskinan yang lebih difokuskan pada daerah dengan tingkat kemiskinan yang masih cukup tinggi.
Adubação potássica em características agronômicas e pós-colheita de melancia
Authors: Gomes Taiuan Bruno Almeida , Tavares Aline Torquato , Neto João Francisco Matos , Reyes Irais Dolores Pascual , Benetti Milena , Carline João Victor Gonçalves , Pereira Fernanda Fonseca , Nascimento Ildon Rodrigues do
Published: August 2020

As adubações com potássio são essenciais para o desenvolvimento do fruto de melancia desde sua formação, amadurecimento, textura e palatabilidade. O objetivo deste trabalho foi avaliar o efeito da adubação potássica em características agronômicas e pós-colheita de melancia. O delineamento experimental utilizado foi o de blocos casualizados com quatro repetições. Foram testados cinco doses de adubação potássica, os quais foram: 0; 60; 120; 180 e 240 kg ha-1 K2O na forma de cloreto de potássio com concentração de 60% de K2O em adubação de base e em duas de cobertura. As demais exigências nutricionais da cultura foram feitas conforme a necessidade nutricional. A cultivar utilizada foi a Manchester®, utilizando-se seis plantas por parcela. A irrigação foi realizada com mangueiras gotejadoras. Para auxiliar no controle das plantas daninhas e umidade, foi utilizado o mulching. Avaliou-se a produtividade média total (em ton ha-1), peso médio dos frutos (em kg), espessura média da casca na região do pedúnculo (em cm), da região distal (em cm) e teor de açúcares totais (°Brix). A espessura média da casca na região do pedúnculo e na região distal não foi alterada pelas doses de potássio. Por ser um fruto que tem a quantidade de brix ou sólidos solúveis como fator importante, o maior valor 10,3°BRIX foi observado na dose de 107,22 Kg de K2O ha-1 sendo esta a mais indicada. O aumento da dose de potásio promove resposta quadrática para as características produtividade, peso médio de frutos e ºBrix. Já a espessura da casca não é afetada pelo aumento da dose de potássio. A produtividade máxima de frutos estimada em 35 ton ha-1 foi alcançada na dose de 156,83 Kg de K2O ha-1.
The Use of Enhanced External Counterpulsation in the Treatment of Patients with Coronary Artery Disease
Authors: Karaganov K. S. , Lishuta A. S. , Belenkov Y. N.
Published: August 2020

Enhanced external counterpulsation (EECP) is one of the most effective and safe non-invasive methods of treatment for patients with coronary artery disease (CAD), including complicated chronic heart failure (CHF). This method of therapeutic neoangiogenesis, used in conjunction with traditional drug therapy and myocardial revascularization, can significantly improve the quality of management of these patients.

Aim. To study the effect of the EECP course on exercise tolerance, quality of life, structural and functional parameters of blood vessels in patients with verified stable CAD complicated by CHF.

Material and methods. Patients (n=70) with verified stable CAD (angina pectoris class II-III) complicated by CHF class II-III (NYHA) were included in non-randomized uncontrolled study. Data from 67 patients (48 to 74 years old; 47 men and 20 women) were included in the final analysis. All patients had a course of EECP (35 one-hour procedures with a compression pressure of 220-280 mm Hg). All patients initially and 1.5 months after the EECP course had a 6-minute walk test (6MWT), an assessment of the clinical status, quality of life of patients (MLHFQ; Minnesota Living with Heart Failure Questionnaire). Computer nailfold video capillaroscopy, photoplethysmography with pulse wave recording and contour analysis, applanation tonometry to assess central aortic systolic pressure and radial augmentation index (RAI) were performed to assess the structural and functional state of large and microcirculatory vessels.

Results. A statistically significant improvement in exercise tolerance (increase in distance in 6MWT from 212 [189; 273] to 308 [251; 336] m), improvement in the clinical status of patients (decrease in points on the rating scale of clinical state from 6.5±1.8 to 4.4±1,2), improvement in the quality of life according to the MLHFQ questionnaire (from 51.9±6.2 to 38.6±7.1), increase in the left ventricle ejection fraction (from 41.6 [36.6;47.1] to 44.8 [39.5;50.7]%) were found. A statistically significant improvement in endothelial function indices of both large vessels (phase shift: from 5.6 [2.4;7.2] to 6.8 [3.3;8] m/s) and microcirculatory vessels (occlusion index: from 1.5 [1.2;1.7] to 1.66 [1.3;1.9]), as well as a decrease in functional disorders of nailfold capillaries (percent of perfused capillaries, capillary network density in the reactive hyperemia test) also were found. But no statistically significant changes in the structural remodeling indices of both large and microcirculatory vessels were found.

Conclusion. A positive effect of the EECP course both on the functional status with an increase in exercise tolerance and improvement in the quality of life, and on the functional state of large vessels and microvasculature was found in patients with stable CAD complicated by CHF.
A COORDENADORIA PEDAGÓGICA COMO ARTICULADORA DA RELAÇÃO ESCOLA-FAMÍLIA NO CURSO TÉCNICO EM QUÍMICA NA MODALIDADE INTEGRADO AO ENSINO MÉDIO NO IFSC - CÂMPUS JARAGUÁ DO SUL
Authors: Da Silva Priscila Juliana , Pereira Juliana de Souza Augustin , Eissler Valli Regina Antonius
Published: August 2020

Este relato de experiência apresenta a trajetória da Coordenadoria Pedagógica do IFSC - Câmpus Jaraguá do Sul na construção da relação escola-família no curso Técnico em Química na modalidade integrado ao Ensino Médio. Por isso situamos a instituição IFSC, os estudantes e famílias atendidos e relatamos a trajetória da Coordenadoria Pedagógica nesse processo.
Extensão Tecnológica
Authors: Fernando José GARBUIO  , Katia Linhaus de OLIVEIRA  , Éliton PIRES  , Andreia ROLAK
Published: August 2020

O Instituto Federal Catarinense lança mais um número da Revista Extensão Tecnológica, disponibilizando à nossa comunidade. Assim reafirmamos o compromisso da divulgação de ações extensionistas, sejam elas realizadas no âmbito do IFC quanto em outras instituições.

Este número tem um simbolismo especial pelo fato de coincidir com o final da Gestão 2016-2019. Gestão a qual teve como premissa o apoio e incentivo às ações de extensão em nossa instituição. Ações que estavam ligadas aos arranjos produtivos, culturais, e sociais locais, contemplando inúmeras áreas do saber e da extensão, traduzindo nossa capilaridade em Santa Catarina e diversidade de motivos e razões para se “fazer extensão”.

Falando em “fazer extensão”, isso é algo que está no dia a dia do IFC. A final, tudo aquilo que aprendemos, criamos, produzimos, desenvolvemos, inovamos, etc, deve atender ou resolver um problema na comunidade onde estamos inseridos. Neste número resumimos um pouco do que as atividades de extensão são capazes de transformar na vida das pessoas.

Quando falamos em transformar vidas, devemos sempre observar a participação dos estudantes nos projetos e/ou ações extensionistas. Seja este estudante bolsista ou voluntário, podemos perceber o impacto que o desenvolvimento destas atividades faz em seu processo educativo. Tenho certeza, que ao realizar as ações, todos saem um pouco mais cidadãos.

Enfim, esta é uma função do “fazer extensão”, tocar a vida de quem faz e de quem recebe. Assim, esta Revista traz um pouco destes momentos que agora queremos compartilhar com vocês.

 

Os Editores.
FORMAÇÃO DE UM CENTRO DE ESPORTE, CULTURA E LAZER COMO FORMA DE INTEGRAÇÃO ENTRE O IFC-CAMPUS VIDEIRA E A COMUNIDADE VIDEIRENSE
Authors: Frizzo Patrício Gabriela
Published: August 2020

Resumo Trata-se de um relato de experiência, em que o objetivo é descrever como ocorreu a formação de um centro de esporte, cultura e lazer que proporcionou a integração do IFC- Videira com a comunidade local. Os resultados indicam que as atividades de extensão permitiram a integração da escola com a comunidade, além de momentos de lazer e também reflexões entre a vida real e o contexto com as atividades acadêmicas.Palavras-chave: Esporte. Lazer. Cultura. Instituto Federal Catarinense.
Loneliness as a risk factor for frailty transition among older Chinese people
Authors: SHA SHA , Xu Yuebin , Chen Lin
Published: August 2020

Background: Previous literature has reported that loneliness is a strong predictor of frailty risk. However, less is known about the role of loneliness in frailty transition types. This study aimed to examine whether and how loneliness are related to frailty transition among older Chinese people.Methods: Our study used participants (aged ≥60 years) from 2008/2009, 2011/2012 and 2014 waves of the Chinese Longitudinal Healthy Longevity Survey (CLHLS). Loneliness was assessed by a single question asking how often the respondent feels lonely. The FRAIL Scale was created to measure physical frailty for our study, and frailty was also assessed by a broader definition of the frailty index. Frailty transition as an outcome variable has been designed as two types according to the measurement of frailty.Results: Greater loneliness at baseline reduced the possibility of remaining in a robust or prefrail physical frailty state after 3 years (OR=0.78, 95%CI: 0.68–0.91, p<0.01). Greater loneliness was associated with an increased risk of worsening physical frailty over time: compared with those who had never felt lonely, the odds ratios for people who often felt lonely were 1.19 (95%CI: 1.01–1.41, p<0.05) after 3 years and 1.34 (95%CI: 1.08–1.66, p<0.01) after 6 years. The association between loneliness and change in the frailty index differed in the survey periods: loneliness at baseline was found to increase the possibility of participants remaining in frailty (seldom loneliness: OR= 1.78, 95%CI: 1.25–2.55, p<0.01; often loneliness: OR= 1.74, 95%CI: 1.21–2.50, p<0.01) after 6 years, but no significance was shown in the 3-year follow up. Additionally, loneliness at baselines was significantly associated with frailty transition at follow up among the male participants. However, a similar association was not observed among the female participants.Conclusion: Older people with a high level of loneliness tend to be frail in the future, and greater loneliness is related to an increased risk of worsening frailty and remaining frail. Male elderly with a high level of loneliness were more likely to have a worse frailty transition than female elderly in China.
Sex differences in campylobacteriosis incidence rates at different ages - a seven country, multi-year, meta-analysis. A potential mechanism for the infection.
Authors: Green Manfred S , Schwartz Naama , Peer Victoria
Published: August 2020

Background . There is evidence that males have higher incidence rates (IR) of campylobacteriosis than femlaes. The objectives of this study were to determine whether the sex differences differ between age groups and are consistent over different countries and over different time periods.
Methods. We obtained data on incidence rates of campylobacteriosis by sex and age group over a period of 11-26 years from seven countries. Male to female incidence rate ratios (IRR) were computed by age group, country and time period. For each age group, we used meta-analytic methods to combine the IRRs. Sensitivity analysis was used to test whether the results are robust to differences between countries and time periods. Meta-regression was conducted to estimate the different effects of age, country, and time period on the IRR.
Results . In the age groups <1, 1-4, 5-9, 10-14, 15-44, 45-64 and 65+ years old, the pooled IRRs (with 95% CI) were 1.31 (1.26-1.37), 1.34 (1.31-1.37), 1.35 (1.32-1.38), 1.73 (1.68-1.79), 1.10 (1.08-1.12), 1.19(1.17-1.21) and 1.27 (1.24-1.30), respectively. For each age group, the excess campylobacteriosis incidence rates in males differed at different age groups. However, despite some quantitative differences between countries, the excess was consistently present over long time-periods. In meta-regression analysis, age group was responsible for almost all the variation in the IRRs.
Conclusions . The male predominance in campylobacteriosis incidence rates starts in infancy. This suggests that this is due, at least in part, to physiological or genetic differences and not just behavioural factors. These findings can provide clues to the mechanisms of the infection and could lead to more targeted treatments and vaccine development.
Unravelling the role of Mesenchymal Stem/Stromal Cells Secretome in intervertebral disc degeneration in a pro-inflammatory/degenerative ex vivo model
Authors: Ferreira JR , Teixeira GQ , Neto E , Ribeiro-Machado C , Silva AM , Caldeira J , Pereira C Leite , Bidarra S , Maia AF , Lamghari M , Barbosa MA , Gonçalves RM
Published: August 2020

The authors have withdrawn this preprint due to author disagreement.
Spatio-Temporal Impact of Self-Financed Rotavirus Vaccination on Rotavirus and Acute Gastroenteritis Hospitalisations in the Valencia Region, Spain.
Authors: López-Lacort Mónica , Orrico-Sánchez Alejandro , Martínez-Beneito Miguel Ángel , Muñoz-Quiles Cintia , Díez-Domingo Javier
Published: August 2020

Background: Several studies have shown a substantial impact of Rotavirus (RV) vaccination on the burden of RV and all-cause acute gastroenteritis (AGE). However, the results of most impact studies could be confused by a dynamic and complex space-time process. Therefore, there is a need to analyse the impact of RV vaccination on RV and AGE hospitalisations in a space-time framework to detect geographical-time patterns while avoiding the potential confusion caused by population inequalities in the impact estimations.Methods: A retrospective population-based study using real-world data from the Valencia Region was performed among children aged less than 3 years old in the period 2005-2016. A Bayesian spatio-temporal model was constructed to analyse RV and AGE hospitalisations and to estimate the vaccination impact measured in averted hospitalisations. Results: We found important spatio-temporal patterns in RV and AGE hospitalisations, RV vaccination coverage and in their associated adverted hospitalisations. Overall, ~1866 hospital admissions for RV were averted by RV vaccination during 2007–2016. Despite the low-medium vaccine coverage (~50%) in 2015-2016, relevant 36% and 20% reductions were estimated in RV and AGE hospitalisations respectively.Conclusions: The introduction of the RV vaccines has substantially reduced the number of RV hospitalisations, averting ~1866 admissions during 2007-2016 which were space and time dependent. This study improves the methodologies commonly used to estimate the RV vaccine impact and their interpretation.
Assessment of the Quality of Recommendations from 161 Clinical Practice Guidelines Using the Appraisal of Guidelines for Research and Evaluation – Recommendations Excellence (AGREE-REX) Instrument Shows There Is Room for Improvement
Authors: Florez Ivan D , Brouwers Melissa C , Kerkvliet Kate , Spithoff Karen , Alonso-Coello Pablo , Burgers Jako , Cluzeau Francoise , Férvers Beatrice , Graham Ian , Grimshaw Jeremy , Hanna Steven , Kastner Monika , Kho Michelle , Qaseem Amir , Straus Sharon
Published: August 2020

Objective: To assess the quality of recommendations from 161 CPGs using AGREE-REX-D (Appraisal of Guidelines REsearch and Evaluation – Recommendations Excellence Draft).Design: Cross-sectional studySetting: International CPG community.Participants: 322 international CPG developers, users, and researchersIntervention: Participants were assigned to appraise one of 161 CPGs selected for the study using the AGREE-REX prototype toolMain outcome measures: AGREE-REX-D scores of 161 CPGs (7-point scale, maximum 7).Results: Recommendations from 161 CPGs were appraised by 322 participants using the AGREE-REX-D. CPGs were developed by 70 different organizations. The total overall average score of the CPG recommendations was 4.23 (standard deviation (SD)=1.14). AGREE-REX-D items that scored the highest were (mean; SD): Evidence (5.51; 1.14), Clinical relevance (5.95; SD 0.8), and Patients/population relevance (4.87; SD 1.33), while the lowest scores were observed for the Policy values (3.44; SD 1.53), Local applicability (3,56; SD 1.47) and Resources, tools and capacity (3.49; SD 1.44) items. CPGs developed by government-supported organizations and developed in the UK and Canada had significantly higher recommendation quality scores with the AGREE-REX-D tool (p<0.05) than their comparators. Conclusions. We found that there is significant room for improvement of some CPGs such as the considerations of patient/population values, policy values, local applicability and resources, tools and capacity. These findings may be considered a baseline upon which to measure future improvements in the quality of CPGs.
3D printed mask extenders as a supplement to isolation masks to relieve posterior auricular discomfort: an innovative 3D printing response to the COVID-19 pandemic
Authors: O’Connor Zachary , Huellewig Daniel , Sithiyopasakul Peeti , Morris Jason , Gan Connie , Ballard David H
Published: August 2020

Purpose: Many commonly used mask designs are secured by elastic straps looping around the posterior auricular region. This constant pressure and friction against the skin may contribute to increased wearer pain, irritation, and discomfort. The purpose of this work is to report a modified 3D printed mask extender to alleviate discomfort and increase mask wearability by relieving posterior auricular pressure from isolation masks.Methods: Our institutional review board designated this project as non-human research and exempt. As part of resourcing 3D printing laboratories along with individual 3D printers to provide resources to healthcare workers, mask extenders were printed to relieve posterior auricular pressure from individuals wearing isolation masks. The authors modifed an existing mask extender, increasing its length with accompanying peripheral rungs for isolation mask securement. 3D printing was performed with Ultimaker S5 (Ultimaker B.V.; Geldermalsen, Netherlands) and CR-10 (Creality3D; Shenzhen, China) 3D printers using polylactic acid filaments. The author’s modified extended mask extenders were printed and freely delivered to healthcare workers (physicians, nurses, technologists, and other personnel) at the authors’ institution. Results: The final mask extender design was printed with the two 3D printers with a maximum 7 straps printed simultaneously on each 3D printer. Mean print times ranges from 105 minutes for the Ultimaker S5 printer and 150 minutes for the CR-10. 475 mask extenders were delivered to healthcare workers at the authors’ institution, with the demand far exceeding the available supply. Conclusion: We offer a modification of a 3D printed mask extender design that decreases discomfort and increases the wearability of isolation mask designs with ear loops thought to relieve posterior auricular skin pressure and ability to control strap tension. The design is simple, produced with inexpensive material (polylactic acid), and have been well-received by healthcare providers at our institution
The Role of Transcription Factor Ap1 in The Activation of Nrf2/ARE Pathway Through TET1 in Diabetic Nephropathy
Authors: Tan Yongshun , Cao Huaimin , Li Qingfei , Sun Jianjun
Published: August 2020

Background: TET1 abnormal expression is related to tumorigenesis, but its role in diabetic nephropathy (DN), the most common diabetic complication, is unclear. We attempted to probe the possible mechanism of TET1 in DN.Methods: The DN rat model was established and verified by marker detection and histopathological observation. The in vitro model was established in human mesangial cells (HMCs) induced by high glucose (HG), and levels of IL-6, TNF-α, IV-C and FN were examined. The differentially expressed mRNAs were screened out by microarray analysis. The most differentially expressed mRNA (TET1) was overexpressed in DN rats and HMCs to evaluate inflammation, cell viability and apoptosis, biochemical indexes and renal injury. The upstream transcription factor of TET1 was verified, and overexpressed with/without TETE1 to access its role in inflammation and renal injury. The downstream gene and pathway were also verified.Results: TET1 was poorly expressed in DN rats and HG-HMCs. High expression of TET1 decreased biochemical indexes, and renal injury of DN rats, decreased the activity, fibrosis and inflammation of HG-HMCs. Ap1 inhibited TET1 expression, and enhanced secretion of inflammatory factors in HG-HMCs and renal injury in DN rats. TET1 overexpression inhibited the effect of Ap1 on DN. TET1 promoted the transcription of Nrf2. The Ap1/Tet1 axis mediated the Nrf2/ARE pathway activity.Conclusion: Ap1 inhibits TET1 expression and activates the Nrf2/ARE pathway in DN, thus aggravating inflammation and renal injury.
Comparison Between 200 μg and 800 μg of Misoprostol for Cervical Ripening Prior to Operative Hysteroscopy: A Study Protocol for A Randomized Controlled Trial.
Authors: Maior Maria da Conceição Farias Souto , Costa Aurélio Antônio Ribeiro , Souza Alex Sandro Rolland
Published: August 2020

Background: Hysteroscopy, a minimally invasive procedure, has been increasingly used to treat disorders of the cervical canal and uterine cavity. However, difficulties related to the insertion of the hysteroscope through the cervical canal still remain. Although there are reported advantages in reducing cervical resistance with the use of misoprostol for cervical ripening, systematic reviews highlight the need to determine the optimal dose. This study was designed to compare two groups of patients submitted to cervical dilatation prior to operative hysteroscopy and pre-treated with either 200 µg or 800 µg of misoprostol for cervical ripening. Methods: A randomized, quadruple-blind clinical trial with patients submitted to cervical dilatation prior to operative hysteroscopy at university teaching hospitals in Recife, Pernambuco, Brazil. After the internal review boards of the participating institutes had approved the study protocol, data collection began on November 7, 2019, with expected completion on November 1, 2020. Patients included in the study following the informed consent process are randomly allocated to one of two groups, the first allocated to use 200 μg misoprostol and the second to use an 800-μg dose. In both groups, misoprostol will be administered vaginally 10-12 hours prior to operative hysteroscopy. The groups will be compared in relation to intraoperative and postoperative outcomes based on the following endpoints: baseline cervical dilatation, cervical length, degree of difficulty, duration of cervical dilatation, failure to dilate, adverse events and surgical complications. The chi-square test of association, Fisher's exact test and the Mann-Whitney test will be used to compare the groups, with an alpha error of <5% being considered significant. Discussion: The findings of this study will contribute towards establishing the optimal misoprostol dose for cervical ripening prior to operative hysteroscopy, ultimately facilitating hysteroscope insertion through the cervical canal. A gap will be filled in the currently available literature, providing future preoperative guidance. The 800-μg dose of misoprostol is expected to reduce resistance in the cervix and shorten the time until achieving cervical dilatation, delivering a less traumatic procedure for the patient. Therefore, the study is relevant for surgeons in this field, for the scientific community and, particularly, for patients. Trial registration: Clinical Trials Register: NCT04152317. Registered on November 5, 2019. URL https://clinicaltrials.gov/ct2/show/study/NCT04152317.
Novel immune-related genes in the tumor microenvironment with prognostic value in breast cancer
Authors: Tan Wen , Liu Maomao , Wang Liangshan , Guo Yang , Wei Changsheng , Zhang Shuqi , Luo Chengyu , Liu Nan
Published: August 2020

Background: Breast cancer is one of the most frequently diagnosed cancers among women worldwide. Alterations in the tumor microenvironment (TME) have been increasingly recognized as key in the development and progression of breast cancer in recent years. To deeply comprehend the gene expression profiling of the TME and identify immunological targets, as well as determine the relationship between gene expression and different prognoses is highly critical. Results: The stromal/immune scores of breast cancer patients from The Cancer Genome Atlas were employed to comprehensively evaluate the TME. Although the TME did not correlate with the stages of breast cancer, it was closely associated with the subtypes of breast cancer and gene mutations (CDH1, TP53 and PTEN), and had immunological characteristics. Based on Gene Ontology (GO) functional enrichment analysis, the upregulated genes from the high vs low immune score groups were mainly involved in T cell activation, the external side of the plasma membrane, and receptor ligand activity. We further analyzed and screened the overlapping genes of the top 3 GO terms and upregulated differentially expressed genes (DEGs). Overall survival, time-dependent receiver operating characteristic (ROC), and protein-protein interaction (PPI) network analyses revealed that the genes of the top GO terms of the upregulated DEGs from the high vs low immune score groups exhibited better prognosis in breast cancer; 15 of them were related to good prognosis in breast cancer, especially CD226 and KLRC4-KLRK1.Conclusions: High CD226 and KLRC4-KLRK1 expression levels were identified and validated to correlate with better overall survival in specific stages or subtypes of breast cancer. CD226, KLRC4-KLRK1 and other new targets seem to be promising avenues for promoting antitumor targeted immunotherapy in breast cancer.
A Comparison Between Different Anti-retroviral Therapy Regimes on Soluble Infammation Markers: a Pilot Study
Authors: Maritati Martina , Alessandro Trentini , Zanotta Nunzia , Comar Manola , Bellini Tiziana , Sighinolfi Laura , Contini Carlo
Published: August 2020

Background: Although HIV-related deaths have decreased dramatically following the introduction of antiretroviral therapy (ART), HIV infection itself causes increased morbidity and mortality for both non-AIDS-related events or chronic inflammation and immune activation. The use of certain antiretroviral drugs can contribute to this process.Methods: We investigated 26 potential biomarkers in serum samples from HIV-1 infected patients virologically suppressed under ART. The main objective of our study was to evaluate if virological suppression achieved with a triple drug regimen containing tenofovir disoproxil fumarate co-formulated with emtricitabine (TDF/FTC) as backbone, could correlate with a better immunological and inflammatory profile in relation to the third class of antiretroviral drug administered. The eligible patients were then divided into 3 groups in relation to the third drug associated with TDF/FTC: nucleoside reverse transcriptase inhibitors (NNRTI) (Group 1, n=16), protease inhibitors (PI) (Group 2, n=17) and integrase inhibitors (INI) (Group 3, n=16).Results: Inflammatory cytokines and chemokines were more represented in Group 2 than in Group 3 (IL-1Ra, p=0.013; IL-12p70 p=0.039; TNF-α p=0.041; IL-8, p=0.027; MIP1 β, p=0.033). Eotaxin showed lower levels in Group 1 compared to Group 2 (p=0.010), while IP-10 was significantly lower in Group 1 compared to both Group 2 and Group 3 (p=0.003 and p=0.007, respectively).Conclusions: our results seem to discourage the administration of PI as a third drug in a virologically effective antiretroviral regimen, as its use is linked to the detection of higher levels of pro-inflammatory mediators in comparison with INI and NNRTI.
Development of a novel nomogram for the prediction of cause specific survival for patients with non-metastatic Chromophobe Cell Renal Carcinoma, following radical nephrectomy
Authors: Liu Feng , Cai Meng Hui , Ge Tian yu , Feng Zi Hao , Huang Kung Ping , Ge Bo
Published: August 2020

Background:The applicability of the nomogram approach to the prognosis of CCRC patients following radical nephrectomy has yet been established or tested. In this study, we utilized data from a large publicly available US cancer database to obtain a large sample size of data on CCRC patients, and used this dataset to evaluate the independent prognostic risk factors for cause-specific survival (CSS) in patients with non-metastatic CCRC. The data were used to construct a new novel prognostic nomogram for CCRC following radical nephrectomy in order to provide a clinically useful predictive tool for estimating a patient's survival probability.This study aimed to establish a novel prognostic nomogram for patients with non-metastatic Chromophobe Cell Renal Carcinoma (CCRC) after radical nephrectomy.Methods:A total of 1040 CCRC patients with non-metastatic cancer who had undergone radical nephrectomy, were identified in SEER (2004 through 2014). A novel nomogram was constructed based on the data and variables associated with cause specific survival time were included in the model using the Cox Proportional-Hazards Model. The nomogram was cross-validated against a subset of the data (n = 520 patients) from 9 randomly selected cancer registries in SEER, by calculation of Harell’s Concordance index (C-index) and the calibration curve for the time-related probability of survival. Results:Multivariate analysis of the training dataset (n = 1040 patients) revealed age at diagnosis, tumor size and tumor grade as independent factors associated with cause specific survival (CSS), and these were selected for inclusion in the nomogram. The calibration curve for the time-limited probability of survival showed good agreement between the predictions of the nomogram and actual observation. The C-index of the nomogram for predicting survival was 0.81 (95% CI 0.75 - 0.87), which was statistically higher than the C-index values produced by the 6/7th AJCC systems (0.75, 95% CI 0.67 - 0.83). The nomogram prediction of survival based on the validation dataset was also superior to that of the 6/7th AJCC staging systems (C-index 0.83 vs. 0.71; P = 0.038 ). Conclusion：The nomogram prediction model we built has a higher C index value, and has better sensitivity and predictive value. A prospective study with a larger sample is needed to verify our findings.
Pathways Leading to Prevention of Fatal and Non-Fatal Cardiovascular Disease: An Interaction Model on 15 years Population-Based Cohort study
Authors: Shakibaei Najmeh , Hassannejad Razieh , Mohammadifard Noushin , Marateb Hamid Reza , Mansourian Marjan , Mañanas Miguel Angel , Sarrafzadegan Nizal
Published: August 2020

Background: A comprehensive study on the interaction of cardiovascular disease (CVD) risk factors is critical to prevent cardiovascular events. The main focus of this study is thus to understand direct and indirect relationships between different CVD risk factors. Methods: A longitudinal data on adults aged ≥35 years, who were free of CVD at baseline, were used in this study. The endpoints were CVD events, whereas their measurements were demographic, lifestyle components, socio-economics, anthropometric measures, laboratory findings, quality of life status, and psychological factors. A Bayesian structural equation modelling was used to determine the relationships among 21 relevant factors associated with total CVD, stroke, acute coronary syndrome (ACS), and fatal CVDs. Results: In this study, a total of 3161 individuals with complete information were involved in the study. A total of 407 CVD events, with an average age of 54.77(10.66) years, occurred during follow-up. The causal associations between six latent variables were identified in the causal network for fatal and non-fatal CVDs. Lipid profile, with the coefficient of 0.26 (0.01), influenced the occurrence of CVD events as the most critical factor, while it was indirectly mediated through risky behaviours and comorbidities. Lipid profile at baseline was influenced by a wide range of other protective factors, such as quality of life and healthy lifestyle components. Conclusions: Analysing a causal network of risk factors revealed the flow of information in direct and indirect paths. It also determined predictors and demonstrated the utility of integrating multi-factor data in a complex framework to identify novel preventable pathways to reduce the risk of CVDs.
The Latest Research Trends of Teaching & Learning in Higher Education by Leveraging Advanced technology and Big data
Authors: Park Young-Eun
Published: August 2020

Digital transformation in higher education has had a transformative effect on modern education. It means transforming an institutional core value of education to better meet students’ needs by leveraging digital technology and big data. Accordingly, this study aims to catch the principal directions, trends, or new paradigms as predictors with a linkage of each topic by identifying the latest research agendas of teaching and learning in higher education through semantic network analysis. For this, 285 research articles from four international ‘top-tier’ journals ranked as ISI/SCOPUS Q1 were gathered in the area of teaching and learning in higher education for two years in 2018 ~ 2019, and then it was analyzed using a text mining technique that processes natural language. Consequently, the study of researches on teaching and learning shows a relatively high connection with ‘student’ or ‘student-centered/led’ rather than ‘teacher-led’. Moreover, it is observed that the practice and assessment of learning can be achieved through various activities including community activities. Besides that, experience-based classes, research in academic contexts, the effect of group activities, how students’ perceptions or feelings and relationships affect learning outcomes were mentioned as the main topics through topic modeling of LDA, a machine learning algorithm. This study proposes that educators, researchers, and academic leaders can exert the remarkable power to reshape the educational programs for future quality education properly and a timely fashion based on recognizable trends or topics in teaching and learning of higher education.
Silver Nanoparticles Protects Streptozotocin-induced Hepatotoxicity: a Biochemical and Histopathological Approach
Authors: BEGUM QUDSIA , Mahboob Tabassum
Published: August 2020

Recently in many industries biologically synthesized silver nanoparticles are used as an alternative for their biomedicinal applications predominantly demonstrated as an effective agent in the diabetes treatment. On the other hand, oxidative stress crucially associated with the pathogenesis of diabetic comorbidities like diabetic hepatopathy, which is less common. Thus, the existing study explored the protective role of biologically synthesized silver nanoparticles (AV-AgNPs) against hepatic toxicity persuaded by streptozotocin (STZ) in rats. Wistar male albino rats (200 ± 20 g) were segregated into five groups (n=10) and designated as, Group I-Control (no treatment); Group II-Diabetic control (35 mg/kg single dose of streptozotocin, IP); Group III-Diabetic treated with AV-AgNPs (10 mg/kg); Group IV-Diabetic treated with aloe vera leaves extract (AVLE) (100 mg/kg); Group V-Diabetic treated with glibenclamide (GLB) (600 μg/kg) orally. After treatment of 28 days, animals were euthanized and collected blood and liver specimens for investigations of biochemical, oxidative stress, antioxidant, and histological parameters. Outcomes of the study exhibited that STZ persuades diabetes and hepatic impairments indicated by significant raised (p<0.05) in the levels of blood glucose, alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase, (ALP), and malondialdehyde (MDA) with decreased catalase (CAT), superoxide dismutase (SOD), and glutathione reductase (GSH) enzymes activities. AV-AgNPs treatment reverted and reestablished the liver enzymes levels, antioxidant enzymes, and histological damages of the liver persuaded by STZ near to normal. In general, these results suggested that AV-AgNPs may have antioxidant potentials and proved to be hepatoprotective therefore, they could be used for the treatment of diabetic hepatopathy and other liver injuries.