bluuebunny/crossref_metadata_2025 huggingface dataset:
The Asymmetric Laplace Gaussian (ALG) Distribution as the Descriptive Model for the Internal Proactive Inhibition in the Standard Stop Signal Task
Authors: Soltanifar Mohsen , Escobar Michael , Dupuis Annie , Chevrier Andre , Schachar Russell
Published: June 2022

Measurements of response inhibition components of reactive inhibition and proactive inhibition within the stop-signal paradigm have been of particular interest to researchers since the 1980s. While frequentist nonparametric and Bayesian parametric methods have been proposed to precisely estimate the entire distribution of reactive inhibition, quantified by stop signal reaction times (SSRT), there is no method yet in the stop signal task literature to precisely estimate the entire distribution of proactive inhibition. We identify the proactive inhibition as the difference of go reaction times for go trials following stop trials versus those following go trials and introduce an Asymmetric Laplace Gaussian (ALG) model to describe its distribution. The proposed method is based on two assumptions of independent trial type (go/stop) reaction times and Ex-Gaussian (ExG) models. Results indicated that the four parametric ALG model uniquely describes the proactive inhibition distribution and its key shape features, and its hazard function is monotonically increasing, as are its three parametric ExG components. In conclusion, the four parametric ALG model can be used for both response inhibition components and its parameters and descriptive and shape statistics can be used to classify both components in a spectrum of clinical conditions.
Attitudes and Involvement of Employees in the Process of Implementing Innovations and Changes in Companies
Authors: Lušňáková Zuzana , Benda-Prokeinová Renáta , Juríčková Zuzana
Published: June 2022

The main goal of the paper is to evaluate the perception and acceptance of change by human resources in companies in Slovakia and to propose specific recommendations to increase the involvement and active approach of business representatives in the interest of business sustainability. Based on the set goal, the issue of perception and attitudes of employees were evaluated through data obtained by a questionnaire survey through a sample survey in 816 companies operating in the Slovak Republic. The obtained data were analyzed using association analysis by application of the independence test based on formulated hypotheses and the found dependencies were presented by correspondence analysis. Innovative activities of companies do not always have to be perceived only positively by employees and it is also appropriate to consider the opposite behavior of employees. To minimize adverse events, we recommend companies formulate appropriate strategies to reduce and overcome the effects of negative attitudes to organizational change and then implement them appropriately, which is essential for the successful implementation of innovative practices.
Energy-Efficient Solutions Depending on Building Forms Design with Tilted South and North Facades
Authors: Freewan Ahmed A. Y.
Published: June 2022

Interactions between buildings and outdoor environment variables, such as the sun, wind and precipitation, depend on building parameters such as orientation, colours, materials and forms. Building forms are one of the most important parameters that directly impact the cooling and heating load energy consumption, daylight environment and urban sustainability. The current study focused on how building forms affect the energy performance of buildings. Inclined forms that were shaped based on the inclination of south and north facades were studied. Many methods were used to explore the impacts of several variables, including exposure to direct sunrays and heating and cooling load. Thermal performance and energy consumption were investigated for many inward- and outward-tilted angles forms for both the south and north directions and compared to vertical facades. In addition, the study developed new building forms based on a combination of south and north tilted forms, which have low energy consumption. The configurations achieved an acceptable balance between cooling and heating energy consumption. A series of computer simulations were developed using energy plus a calculation engine within DesignBuilder, SunCast, Radiance and IES VE. The results showed that outward-tilted facades for the south orientation perform well, as they reduced the cooling load due to self-shading. Building forms that balanced south and north tilted facades saved the most energy. South-tilted facades forming only 30° angles performed the best, with average energy savings of 20%. Meanwhile, forms with 30° south-tilted facade and 10° tilted north facades, such as forms 3–6, reduced energy consumption by more than 23% compared to the base case.
Diagonal Tension Cracking Strength and Risk of RC Deep Beams
Authors: Chen Hui , Yi Wei-Jian , Zhou Ke-Jing
Published: June 2022

This study focuses on the shear serviceability of simple and continuous reinforced concrete deep beams. The test results of 81 simple deep beams (i.e., simply supported single-span deep beams) and 29 continuous deep beams, for which their diagonal tension cracking loads were reported, were collected from existing studies. On this basis, the diagonal tension cracking mechanism is discussed, and four existing models for diagonal tension cracking are evaluated. The evaluation results show the existing models fail to accurately reflect the influences of the main design parameters (including the shear span-to-effective depth ratio and main tensile reinforcement ratio) on the diagonal tension cracking strength. Therefore, a new equation for the diagonal tension cracking strength for simple and continuous deep beams is proposed. The proposed equation is verified to be superior to the existing models, showing an average value and a coefficient of variation for tested-to-predicted diagonal tension cracking strength ratios of 1.02 and 0.21, respectively. On the other hand, a probabilistic analysis is conducted to evaluate the diagonal tension cracking risk under service load, showing that 35% of deep beams exhibited a diagonal tension cracking load that is less than the service load, which indicated that diagonal cracks easily occur in RC deep beams under service loads.
A Systematic Review of the Current Status and Quality of Radiomics for Glioma Differential Diagnosis
Authors: Brancato Valentina , Cerrone Marco , Lavitrano Marialuisa , Salvatore Marco , Cavaliere Carlo
Published: June 2022

Radiomics is a promising tool that may increase the value of imaging in differential diagnosis (DDx) of glioma. However, implementation in clinical practice is still distant and concerns have been raised regarding the methodological quality of radiomic studies. Therefore, we aimed to systematically review the current status of radiomic studies concerning glioma DDx, also using the radiomics quality score (RQS) to assess the quality of the methodology used in each study. A systematic literature search was performed to identify original articles focused on the use of radiomics for glioma DDx from 2015. Methodological quality was assessed using the RQS tool. Spearman’s correlation (ρ) analysis was performed to explore whether RQS was correlated with journal metrics and the characteristics of the studies. Finally, 42 articles were selected for the systematic qualitative analysis. Selected articles were grouped and summarized in terms of those on DDx between glioma and primary central nervous system lymphoma, those aiming at differentiating glioma from brain metastases, and those based on DDx of glioma and other brain diseases. Median RQS was 8.71 out 36, with a mean RQS of all studies of 24.21%. Our study revealed that, despite promising and encouraging results, current studies on radiomics for glioma DDx still lack the quality required to allow its introduction into clinical practice. This work could provide new insights and help to reach a consensus on the use of the radiomic approach for glioma DDx.
Anti-Cancer Effects of YAP Inhibitor (CA3) in Combination with Sorafenib against Hepatocellular Carcinoma (HCC) in Patient-Derived Multicellular Tumor Spheroid Models (MCTS)
Authors: Han Sojung , Lim Ji Yeon , Cho Kyungjoo , Lee Hye Won , Park Jun Yong , Ro Simon Weonsang , Kim Kyung Sik , Seo Haeng Ran , Kim Do Young
Published: June 2022

Purpose: To assess the expression levels of YAP and TAZ in patient-derived HCC tissue and identify the effects of YAP/TAZ inhibition depending on the baseline YAP/TAZ expression when combined with sorafenib using a patient-derived multicellular tumor spheroid (MCTS) model. Methods: Primary HCC cell lines were established from patient-derived tissue. Six patient-derived HCC cell lines were selected according to YAP/TAZ expression on Western blot: high, medium, low. Then, MCTS was generated by mixing patient-derived HCC cells and stroma cells (LX2, WI38, and HUVECs) and YAP/TAZ expression was assessed using Western blot. Cell viability of MCTS upon 48 h of drug treatment (sorafenib, sorafenib with CA3 0.1 µM, and CA3 (novel YAP1 inhibitor)) was analyzed. Results: Out of six patient-derived HCC cell lines, cell lines with high YAP/TAZ expression at the MCTS level responded more sensitively to the combination therapy (Sorafenib + CA3 0.1 μM) despite the potent cytotoxic effect of CA3 exhibited in all of the patient-derived HCCs. Conclusion: Targeting YAP/TAZ inhibition using the novel YAP1 inhibitor CA3 could be a promising therapeutic strategy to enhance sensitivity to sorafenib especially in HCCs with high YAP/TAZ expression in MCTS.
CT-Based Radiomics and Deep Learning for BRCA Mutation and Progression-Free Survival Prediction in Ovarian Cancer Using a Multicentric Dataset
Authors: Avesani Giacomo , Tran Huong Elena , Cammarata Giulio , Botta Francesca , Raimondi Sara , Russo Luca , Persiani Salvatore , Bonatti Matteo , Tagliaferri Tiziana , Dolciami Miriam , Celli Veronica , Boldrini Luca , Lenkowicz Jacopo , Pricolo Paola , Tomao Federica , Rizzo Stefania Maria Rita , Colombo Nicoletta , Manganaro Lucia , Fagotti Anna , Scambia Giovanni , Gui Benedetta , Manfredi Riccardo
Published: June 2022

Purpose: Build predictive radiomic models for early relapse and BRCA mutation based on a multicentric database of high-grade serous ovarian cancer (HGSOC) and validate them in a test set coming from different institutions. Methods: Preoperative CTs of patients with HGSOC treated at four referral centers were retrospectively acquired and manually segmented. Hand-crafted features and deep radiomics features were extracted respectively by dedicated software (MODDICOM) and a dedicated convolutional neural network (CNN). Features were selected with and without prior harmonization (ComBat harmonization), and models were built using different machine learning algorithms, including clinical variables. Results: We included 218 patients. Radiomic models showed low performance in predicting both BRCA mutation (AUC in test set between 0.46 and 0.59) and 1-year relapse (AUC in test set between 0.46 and 0.56); deep learning models demonstrated similar results (AUC in the test of 0.48 for BRCA and 0.50 for relapse). The inclusion of clinical variables improved the performance of the radiomic models to predict BRCA mutation (AUC in the test set of 0.74). Conclusions: In our multicentric dataset, representative of a real-life clinical scenario, we could not find a good radiomic predicting model for PFS and BRCA mutational status, with both traditional radiomics and deep learning, but the combination of clinical and radiomic models improved model performance for the prediction of BRCA mutation. These findings highlight the need for standardization through the whole radiomic pipelines and robust multicentric external validations of results.
Longitudinal Collection of Patient-Reported Outcomes and Activity Data during CAR-T Therapy: Feasibility, Acceptability, and Data Visualization
Authors: Oswald Laura B. , Li Xiaoyin , Carvajal Rodrigo , Hoogland Aasha I. , Gudenkauf Lisa M. , Hansen Doris K. , Alsina Melissa , Locke Frederick L. , Rodriguez Yvelise , Irizarry-Arroyo Nathaly , Robinson Edmondo J. , Jim Heather S. L. , Gonzalez Brian D. , Kirtane Kedar
Published: June 2022

Background: Clinicians must closely monitor patients for toxicities after chimeric antigen receptor T-cell therapy (CAR-T). Patient-reported outcomes (PROs) (e.g., toxicities, quality of life) and activity data (e.g., steps, sleep) may complement clinicians’ observations. This study tested the feasibility and acceptability of collecting PROs and activity data from patients with hematologic malignancies during CAR-T and explored preliminary data patterns. Methods: Participants wore a Fitbit tracker and completed PROs at several timepoints through 90-days post-infusion. Feasibility was assessed with a priori benchmarks for recruitment (≥50%), retention (≥70%), PRO completion (≥70%), and days wearing the Fitbit (≥50%). Acceptability was assessed with participant satisfaction (a priori benchmark > 2 on a 0–4 scale). Results: Participants (N = 12) were M = 66 years old (SD = 7). Rates of recruitment (68%), retention (83%), PRO completion (85%), and days wearing the Fitbit (85%) indicated feasibility. Satisfaction with completing the PROs (M = 3.2, SD = 0.5) and wearing the Fitbit (M = 2.9, SD = 0.5) indicated acceptability. Preliminary data patterns suggested that participants with better treatment response (vs. progressive disease) had a higher toxicity burden. Conclusions: Longitudinal PRO and activity data collection was feasible and acceptable. Data collected on a larger scale may be used to specify risk prediction models to identify predictors of severe CAR-T-related toxicities and inform early interventions.
P2X Purinergic Receptors Are Multisensory Detectors for Micro-Environmental Stimuli That Control Migration of Tumoral Endothelium
Authors: Scarpellino Giorgia , Genova Tullio , Quarta Elisa , Distasi Carla , Dionisi Marianna , Fiorio Pla Alessandra , Munaron Luca
Published: June 2022

The tumoral microenvironment often displays peculiar features, including accumulation of extracellular ATP, hypoxia, low pH-acidosis, as well as an imbalance in zinc (Zn2+) and calcium (Ca2+). We previously reported the ability of some purinergic agonists to exert an anti-migratory activity on tumor-derived human endothelial cells (TEC) only when applied at a high concentration. They also trigger calcium signals associated with release from intracellular stores and calcium entry from the external medium. Here, we provide evidence that high concentrations of BzATP (100 µM), a potent agonist of P2X receptors, decrease migration in TEC from different tumors, but not in normal microvascular ECs (HMEC). The same agonist evokes a calcium increase in TEC from the breast and kidney, as well as in HMEC, but not in TEC from the prostate, suggesting that the intracellular pathways responsible for the P2X-induced impairment of TEC migration could vary among different tumors. The calcium signal is mainly due to a long-lasting calcium entry from outside and is strictly dependent on the presence of the receptor occupancy. Low pH, as well as high extracellular Zn2+ and Ca2+, interfere with the response, a distinctive feature typically found in some P2X purinergic receptors. This study reveals that a BzATP-sensitive pathway impairs the migration of endothelial cells from different tumors through mechanisms finely tuned by environmental factors.
Updates in Biliary Tract Cancers
Authors: Li Daneng , Zhang Ya-Han , Crook Christiana J. , Iyer Renuka V.
Published: June 2022

Biliary tract cancers (BTCs) are a heterogeneous group of malignancies arising from the epithelium of the biliary tree [...]
Hypoxia Selectively Increases a SMAD3 Signaling Axis to Promote Cancer Cell Invasion
Authors: Brochu-Gaudreau Karine , Charbonneau Martine , Harper Kelly , Dubois Claire M.
Published: June 2022

Transforming growth factor β (TGFβ) plays a paradoxical role in cancer, first inhibiting then promoting its progression, a duality that poses a real challenge for the development of effective TGFβ-targeted therapies. The major TGFβ downstream effectors, SMAD2 and SMAD3, display both distinct and overlapping functions and accumulating evidence suggests that their activation ratio may contribute to the dual effect of TGFβ. However, the mechanisms responsible for their selective activation remain poorly understood. Here, we provide experimental evidence that hypoxia induces the pro-invasive arm of TGFβ signaling through a selective increase in SMAD3 interaction with SMAD-Anchor for Receptor Activation (SARA). This event relies on HDAC6-dependent SMAD3 bioavailability, as well as increased SARA recruitment to EEA1+ endosomes. A motility gene expression study indicated that SMAD3 selectively increased the expression of ITGB2 and VIM, two genes that were found to be implicated in hypoxia-induced cell invasion and associated with tumor progression and metastasis in cohorts of cancer patients. Furthermore, CAM xenograft assays show the significant benefit of selective inhibition of the SMAD3 signaling pathway as opposed to global TGFβ inhibition in preventing tumor progression. Overall, these results suggest that fine-tuning of the pro-invasive HDAC6-SARA-SMAD3 axis could be a better strategy towards effective cancer treatments.
Targeting the Subventricular Zone to Promote Myelin Repair in the Aging Brain
Authors: Butt Arthur Morgan , Rivera Andrea Dominico , Fulton Daniel , Azim Kasum
Published: June 2022

The subventricular zone (SVZ) is the largest and most active germinal zone in the adult forebrain. Neural stem cells (NSCs) of the SVZ generate olfactory interneurons throughout life and retain the intrinsic ability to generate oligodendrocytes (OLs), the myelinating cells of the central nervous system. OLs and myelin are targets in demyelinating diseases such as multiple sclerosis (MS). Remyelination is dependent on the ability of oligodendrocyte progenitor cells (OPCs) to proliferate, migrate, and terminally differentiate into myelinating OLs. During aging, there is a gradual decrease in the regenerative capacity of OPCs, and the consequent loss of OLs and myelin is a contributing factor in cognitive decline and the failure of remyelination in MS and other pathologies with aging contexts, including Alzheimer’s disease (AD) and stroke. The age-related decrease in oligodendrogenesis has not been fully characterised but is known to reflect changes in intrinsic and environmental factors affecting the ability of OPCs to respond to pro-differentiation stimuli. Notably, SVZ-derived OPCs are an important source of remyelinating OLs in addition to parenchymal OPCs. In this mini-review, we briefly discuss differences between SVZ-derived and parenchymal OPCs in their responses to demyelination and highlight challenges associated with their study in vivo and how they can be targeted for regenerative therapies in the aged brain.
Association between Parents’ Relationship, Emotion-Regulation Strategies, and Psychotic-like Experiences in Adolescents
Authors: Zhan Chenyu , Mao Ziyu , Zhao Xudong , Shi Jingyu
Published: June 2022

This study aimed to examine the association between the psychotic-like experiences (PLEs) and emotion-regulation (ER) strategies of adolescents and their parents’ relationship, and we hypothesized that the parents’ relationship moderates the link between ER strategies and PLEs. We recruited a total of 2708 first-year college students (1659 males and 1049 females) aged 15–20 years (mean = 17.9). Participants completed assessments of PLEs, their use of ER strategies, and reported their parents’ relationship as harmonious, conflicting, or divorced. Regression analyses indicated that the lower the use of the emotion-reappraisal strategy, the greater the use of the emotion-suppression strategy and that parental conflict or divorce predicted the number of PLEs endorsed and the level of distress from the PLEs. The parents’ relationship moderated the association between ER strategies and distress from PLEs. Among those who reported parental conflict or divorce, their lower use of the reappraisal strategy predicted their experiencing higher levels of distress from their PLEs. This study suggested the direct and interactive influence of the parents’ relationship and ER strategies on the presence of PLEs and PLE-related distress levels among adolescents, which may represent potential intervention targets.
Inconsistent Media Mediation and Problematic Smartphone Use in Preschoolers: Maternal Conflict Resolution Styles as Moderators
Authors: Yang Hwajin , Ng Wee Qin , Yang Yingjia , Yang Sujin
Published: June 2022

Previous studies suggest that inconsistent parenting leads to undesired consequences, such as a child’s defiant reactance or parent–child conflicts. In light of this, we examined whether mothers’ inconsistent smartphone mediation strategies would influence their children’s problematic smartphone use during early childhood. Furthermore, given that harsh parenting often escalates a child’s behavioral problems, we focused on parent–child conflict resolution tactics as moderators. One hundred fifty-four mothers (ages 25–48 years; M = 35.58 years) of preschoolers (ages 42–77 months) reported their media mediation and parent–child conflict resolution tactics and their child’s problematic smartphone use. We found that the positive association between the mother’s inconsistent mediation and their child’s problematic smartphone use was more pronounced when mothers relied on negative parent–child resolution tactics—i.e., psychological aggression and physical assault. Our findings provide vital theoretical and empirical insights into mother–child relational characteristics for the child’s problematic smartphone use.
Investigating the Relation of Intelligence and Executive Functions in Children and Adolescents with and without Intellectual Disabilities
Authors: Johannsen Mieke , Krüger Nina
Published: June 2022

Despite their separate research traditions, intelligence and executive functioning (EF) are both theoretically and empirically closely related to each other. Based on a subsample of 8- to 20-year-olds of the standardization and validation sample (N = 1540) of an internationally available instrument assessing both cognitive abilities, this study aimed at investigating a comprehensive structural model of intelligence and EF tasks and at gaining insight into whether this comprehensive model is applicable across sexes and age groups as well as to a subsample of participants with (borderline) intellectual disabilities (IQ ≤ 85, n = 255). The results of our exploratory factor analysis indicated one common EF factor that could be sufficiently integrated into the intelligence model within our confirmatory factor analyses. The results suggest that the EF factor can be added into the model as a sixth broad ability. The comprehensive model largely showed measurement invariance across sexes and age groups but did not converge within the subsample of participants with (borderline) intellectual disabilities. The results and implications are discussed in light of the current literature.
Persistent Asthma in Childhood
Authors: Söderhäll Cilla , Schoos Ann-Marie Malby
Published: June 2022

Asthma is the most common chronic disease in children and a cause of great distress for both the children and their families [...]
Ascorbic Acid Ameliorates Cardiac and Hepatic Toxicity Induced by Azithromycin-Etoricoxib Drug Interaction
Authors: Hamza Reham , Alaryani Fatima , Omara Fatma , Said Mahmoud , El-Aziz Sayed , El-Sheikh Sawsan
Published: June 2022

The complexity of prescribing safe and effective drug therapy is still challenging. Due to the increased number of medications taken by patients, the potential for drug-drug interactions has clinically important consequences. This study focuses on the potential drug-drug interaction between azithromycin and etoricoxib and the possibility of counteracting this adverse reaction by giving ascorbic acid intraperitoneally to male albino rats. Sixty adult male albino rats weighing 150–180 g were used. The rats were allocated into six equal groups. One group was a control, and the others were given azithromycin, etoricoxib, either alone or combination, with one group treated with ascorbic acid and the last group treated with the drug combination and ascorbic acid. Blood samples were collected for measuring AST, ALT, LDH, CK-MB, and troponin alongside antioxidant enzymes and histopathological examination for both liver and heart tissue. The results showed both hepatic and cardiac damage in azithromycin and etoricoxib groups represented by increasing levels of heaptoc enzymes (ALT, AST, LDH, CK-MB, and troponin) with declining antioxidant enzymes and elevation of malondialdehyde and the appearance of hepatic and cardiac toxicities. Upon administration, ascorbic acid ameliorated all the mentioned biochemical parameters. In conclusion, ascorbic acid has great antioxidant capacities and hepatic and cardiac ameliorative effects and can alleviate drug interaction toxicity.
Construction and Characterization of T7 Bacteriophages Harboring Apidaecin-Derived Sequences
Authors: Ludwig Tobias , Hoffmann Ralf , Krizsan Andor
Published: June 2022

The global spread of multi- and pan-resistant bacteria has triggered research to identify novel strategies to fight these pathogens, such as antimicrobial peptides and, more recently, bacteriophages. In a proof-of-concept study, we have genetically modified lytic T7Select phages targeting Escherichia coli Rosetta by integrating DNA sequences derived from the proline-rich antimicrobial peptide, apidaecin. This allowed testing of our hypothesis that apidaecins and bacteriophages can synergistically act on phage-sensitive and phage-resistant E. coli cells and overcome the excessive cost of peptide drugs by using infected cells to express apidaecins before cell lysis. Indeed, the addition of the highly active synthetic apidaecin analogs, Api802 and Api806, to T7Select phage-infected E. coli Rosetta cultures prevented or delayed the growth of potentially phage-resistant E. coli Rosetta strains. However, high concentrations of Api802 also reduced the T7Select phage fitness. Additionally, plasmids encoding Api802, Api806, and Api810 sequences transformed into E. coli Rosetta allowed the production of satisfactory peptide quantities. When these sequences were integrated into the T7Select phage genome carrying an N-terminal green fluorescent protein (GFP-) tag to monitor the expression in infected E. coli Rosetta cells, the GFP–apidaecin analogs were produced in reasonable quantities. However, when Api802, Api806 and Api810 sequences were integrated into the T7Select phage genome, expression was below detection limits and an effect on the growth of potentially phage-resistant E. coli Rosetta strains was not observed for Api802 and Api806. In conclusion, we were able to show that apidaecins can be integrated into the T7Select phage genome to induce their expression in host cells, but further research is required to optimize the engineered T7Select phages for higher expression levels of apidaecins to achieve the expected synergistic effects that were visible when the T7Select phages and synthetic Api802 and Api806 were added to E. coli Rosetta cultures.
Review of Latest Advances and Prospects of Energy Storage Systems: Considering Economic, Reliability, Sizing, and Environmental Impacts Approach
Authors: Kiehbadroudinezhad Mohammadali , Merabet Adel , Hosseinzadeh-Bandbafha Homa
Published: June 2022

Studies have shown that the role of energy storage systems in human life is increasing day by day. Therefore, this research aims to study the latest progress and technologies used to produce energy storage systems. It also discusses and compares the most recent methods used by researchers to model and optimize the size of these tools and evaluates the strengths and weaknesses of each. Investigations have shown that using energy storage systems in hybrid stand-alone power generation systems based on renewable energy increases the reliability of the power generation systems and increases their efficiency. It has also reduced the cost of transmitting the power grid to remote areas. Furthermore, this study showed that advances in energy storage technology in recent years have led to the development and promotion of clean microgrids. In addition, this review paper also addresses energy storage technology issues and proposes practical and applied solutions.
Effect of Ohmic Heating on the Extraction Yield, Polyphenol Content and Antioxidant Activity of Olive Mill Leaves
Authors: Safarzadeh Markhali Fereshteh , Teixeira José A. , Rocha Cristina M. R.
Published: June 2022

This study examined the influence of ohmic heating (OH), compared to the conventional heating (Conven) and Control (solvent) methods, on the extraction of olive mill leaves. The main extraction parameters were: (i) solvent ratio (aqueous ethanol; 40%, 60%, and 80%, v/v), and (ii) extraction temperature; 45 °C, 55 °C, and 75 °C (for OH and Conven), and room temperature (for Control). The selected response variables were extraction yield (%), total phenolic content (TPC), and antioxidant activity (ABTS and DPPH). The ohmic system, compared to Conven and Control, exhibited the greatest effects (p < 0.001) on increasing (i) extraction yield (34.53%) at 75 °C with 80% ethanol, (ii) TPC at 55 °C (42.53, 34.35, 31.63 mg GAE/g extract, with 60%, 40%, and 80% ethanol, respectively), and (iii) antioxidant potency at 75 °C detected by DPPH and ABTS, in the range of 1.21–1.04 mM TE/g, and 0.62–0.48 mM TE/g extract, respectively. Further, there were relatively similar trends in TPC and antioxidant activity (both methods), regardless of solvent ratios, p < 0.001. These findings demonstrate the potential of ohmic heating, as a green processing tool, for efficient extraction (15 min) of olive leaves. To date, no literature has described ohmic application for olive leave extraction.
Wear Resistance, Patterns of Wear and Plastic Properties of Cr,Mo-(Cr,Mo,)N-(Cr,Mo,Al)N Composite Coating with a Nanolayer Structure
Authors: Vereschaka Alexey , Seleznev Anton , Gaponov Vladislav
Published: June 2022

This paper discusses the results of studies focused on the wear resistance, patterns of wear and plastic properties of Cr,Mo-(Cr,Mo,)N-(Cr,Mo,Al)N coating, containing 20 at.% Mo. The coating had a nanolayer structure with a modulation period λ = 50 nm. The studies revealed the hardness, fracture resistance in scratch testing, as well as elemental and phase composition of the coating. The studies of the tool life of carbide cutting tools with the Cr,Mo-(Cr,Mo,)N-(Cr,Mo,Al)N coating proved their longer tool life compared to that of uncoated tools and tools with the reference Cr-(Cr,Al)N coating of equal thickness and equal content of aluminum (Al). The studies included the comparison of the tools coated with Cr,Mo-(Cr,Mo,)N-(Cr,Mo,Al)N and Cr-(Cr,Al)N. The experiments focused on the specific features of the coating nanostructure and were conducted using a transmission electron microscope (TEM), revealing the different mechanisms of fracture. The penetration of particles of the material being machined between nanolayers of the coating results in interlayer delamination. When exposed to a moving flow of the material being machined, plastic deformation (bending) of the coating nanolayers occurs. The diffusion of iron into the coating (up to 200 nm) and diffusion of Cr and Mo into the cut material to a depth of up to 250 nm are observed. The presented information can help in the design of metal cutting tools and the choice of coatings for them.
Adaptive Control of Photovoltaic Systems Based on Dual Active Bridge Converters
Authors: Henao-Bravo Elkin Edilberto , Ramos-Paja Carlos Andrés , Saavedra-Montes Andrés Julián
Published: June 2022

Dual active bridge converters (DAB) are used to interconnect photovoltaic (PV) generators with AC and DC buses or isolated loads. However, a controller is needed to provide a stable and efficient operation of the DAB converter when the PV generator must be interconnected with a DC bus, which is particularly important in microinverter applications. Therefore, this paper proposes the design of a cascade controller for a PV system based on a DAB converter. The converter is controlled using a peak current control and an adaptive PI voltage control; thus the methodology to design the cascade controller is developed in two steps; first, the PV system formed by a PV generator, a DAB converter, and an inverter or load is introduced, including the description of the leakage current; as a second step, the model of the PV system to design the cascade controller is presented. Then, a relationship between the phase shift factor and the peak current of the leakage inductor is derived, which is used to design the peak current controller to ensure the DAB converter operation at the most efficient operating condition. On the other hand, an adaptive PI controller for the PV voltage is designed to ensure the reference tracking provided by a maximum power point (MPP) algorithm. The effectiveness of the proposed cascade controller is demonstrated through realistic examples simulated in PSIM. The power and control circuits implemented in PSIM are presented to encourage the use of the proposed solution. The simulation results confirm the correct operation of the control system, which mitigates the oscillatory perturbation produced by an inverter connected to the PV system, and also ensures the maximum power extraction from the PV panel by following the MPP reference.
Indonesian Cinnamon (Cinnamomum burmannii): Extraction, Flavonoid Content, Antioxidant Activity, and Stability in the Presence of Ascorbic Acid
Authors: Rahayu Dyah Utami Cahyaning , Hakim Regina Ainunnisa , Mawarni Shofi Airiza , Satriani Andhina Rizkya
Published: June 2022

Cinnamon (Cinnamomum burmannii) is a potential source used in cosmetics to prevent skin aging due to its flavonoids and antioxidant properties. This research aims to determine the best solvent for extracting flavonoids, to conduct a large-scale isolation of flavonoids, and to evaluate the effect of ascorbic acid and temperature on the extract’s stability for 16 weeks. Various solvents for small-scale extraction were screened based on the polarity index, and one of the best for use in large-scale maceration was selected based on the AlCl3 colorimetric flavonoid content and DPPH antioxidant activity. The stability test was performed by treating cinnamon with and without ascorbic acid at selected temperatures. This test measured physical stability, evaluated flavonoid content and antioxidant activity, and analyzed volatile and non-volatile compounds using GC-MS and LC-MS. The most excellent solvent to extract flavonoids was ethanol due to its high yield (21.50%), flavonoid content (0.01749 ± 8.0 × 10−5 mg QE/g extract), and antioxidant activity (IC50 0.0162 + 7.5 × 10−4 mg/mL). The ascorbic acid addition at both temperatures affected the stability of the pH and chemical constituents. The vast majority of the extract’s flavonoid content and antioxidant activity continued to increase until the end of the observation week. This study revealed that ethanol was the best extraction solvent, and ascorbic acid can be recommended as a stabilizer of cinnamon extract for use in cosmetics for further application.
Herd Routines and Veterinary Advice Related to Drying-Off and the Dry Period of Dairy Cows
Authors: Persson Waller Karin , Landin Håkan , Nyman Ann-Kristin
Published: June 2022

Bovine mastitis at calving or early lactation is often associated with intra-mammary bacterial infections (IMI) at drying-off (DO) or during the dry period (DP). The IMI risk is associated with management routines at the herd, but knowledge on how farmers and veterinarians comply with national recommendations is scarce, as is their attitudes to the importance of such routines. Therefore, the main aims of this study were to collect information on farmer routines and attitudes, and on veterinary advice and attitudes to DO and DP. Associations between routines and advice, and demographic herd and veterinary variables were also studied. Web-based questionnaires were sent to 2472 dairy farmers and 517 veterinarians. The answers were summarized descriptively, and associations with demographics were evaluated using univariable regression models. The response rate was 14% for farmers and 25% for veterinarians. Routines and advice were in line with recommendations at the time of the study in many, but not all, areas of questioning. Significant associations between herd routines or veterinary advice and demographic variables were also found. Milking system and post-graduate training were the variables associated with the largest number of farmer and veterinary answers, respectively. In conclusion, the results indicate a need for more education on good routines during DO and DP. It was also clear that the national recommendations valid at the time of the study were in need of revision.
Does Low-Taper Root Canal Shaping Decrease the Risk of Root Fracture? A Systematic Review
Authors: Puleio Francesco , Lo Giudice Giuseppe , Militi Angela , Bellezza Ugo , Lo Giudice Roberto
Published: June 2022

Minimal root-canal preparation has been suggested to reduce the risk of root fracture, but as a result, satisfactory cleaning and shaping do not take place. Large-scale taper instrumentation can contribute to removing infected tissue; however, it may weaken the tooth structure. The aim of this systematic review is to evaluate whether root-canal shaping with low-taper instruments decreases the risk of root fracture, compared to high-conicity shaping. A search was performed on Ovid MEDLINE, PubMed, and the Web of Science. The inclusion criteria were: studies comparing the root fracture resistance of endodontically treated teeth, shaped with low- and high-conicity taper instruments, in human trials, and via in vitro study. The review includes all types of endodontically treated teeth, with various instrument tapers. The scientific search engines produced 328 results. Only 20 of the results were evaluated after screening. Based on the articles analyzed, it is not clear whether a taper difference can determine differences in root fracture resistance. No randomized controlled trial (RCTs) with long follow-ups have been published to date. It must also be taken into account that the in vitro studies do not consider the numerous differences that there are between in vitro and clinical evaluation. The review was registered on the PROSPERO website, with the protocol number CRD42020151451.
The Effect of MI Varnish™ on Caries Increment and Dietary Habits among 6- and 12-Year-Old Children in Riga, Latvia: A 3-Year Randomized Controlled Trial
Authors: Gudkina Jekaterina , Amaechi Bennett T. , Abrams Stephen H. , Brinkmane Anda , Petrosina Eva
Published: June 2022

Aims: This randomized controlled trial investigated the effect of MI Varnish™ (5% NaF/CPP-ACP) on caries increment in 6- and 12-year-old children in Riga, Latvia within 36 months. Methods: Forty-eight 6-year-old children (Group 1) and forty-seven 12-year-old children (Group 3) received quarterly varnish application, while forty-eight 6-year-old children (Group 2) and thirty-seven 12-year-old children (Group 4) did not have varnish applied. All children/parents received the same preventive advice. All children were visually examined using ICDAS-II criteria. Questionnaires on dietary habits were completed by the children/parents at baseline and after 36 months. DMFS and dfs were calculated from ICDAS data. The statistical analysis was performed (α = 0.05) using a Chi-squared test, paired t-test (Welch test) and the Pearson correlation coefficient. The trial registration number is ISRCTN10584414. Results: In Group 1 versus Group 2, the DMFS(SD) (Baseline/36 months) values were 5.02(5.85)/13.21(6.67) (p < 0.001) versus 2.65(4.54)/10.81(6.14) (p < 0.001), respectively; the dfs(SD) (Baseline/36 months) values were 36.75(12.96)/24.04(12.9) (p < 0.001) versus 33.67(12.74)/23.88(11.91) (p < 0.001), respectively. In Group 3 versus Group 4, the DMFS(SD) (Baseline/36 months) values were 48.62(23.18)/70.96(23.28) (p < 0.001) versus 34.73(17.99)/54.95(16.09) (p < 0.001), respectively; the dfs(SD) (Baseline/36 months) values were 1.7(4.4)/0 (p < 0.05) versus 2(6.39)/0 (p = 0.06), respectively. The prevalence of caries (dfs + DMFS) decreased by 4.52 (p < 0.001) and 1.63 (p < 0.001) in Groups 1 and 2, respectively, but increased by 20.64 (p < 0.001) and 18.22 (p < 0.001) in Groups 3 and 4, respectively. An analysis of the questionnaires indicated the habitual, frequent consumption of a sugary diet by all the children. A significant correlation (r = 0.321; p < 0.05) was observed between caries increment and the frequency of daily intake of sugary snacks, soft drinks and tea with sugar at baseline only in Group 1. Conclusions: A quarterly application of MI varnish (CPP-ACP/fluoride) reduced caries increment in 6- and 12-year-old children in Riga, Latvia.
Introduction for the Special Issue: Statistical Fluid Dynamics
Authors: Ammar Amine , Chinesta Francisco , Valette Rudy
Published: June 2022

Characterizing complex material consists in establishing the relationship between flow rheology during forming processes and the induced micro-structural state that affects directly the final mechanical properties of the formed parts [...]
The Development of Prospective Primary School Science Teachers’ TPaCK Fostered by Innovative Science-Teacher Education
Authors: Wollmann Karl , Lange-Schubert Kim
Published: June 2022

The EEdnaS study “Development and testing of digitally enriched science-related subject matter teaching in digital teaching-learning labs and university classrooms” aims to promote the professional competencies of prospective teachers that are needed for teaching science content in a world shaped by digitalization. To achieve this goal, university teaching units (seminars) that directly address cognitive components of a teacher’s professional competencies, which are important to teaching science content in primary school education, were developed. In addition, prospective teachers were asked to plan, implement, and evaluate primary school science education with a particular focus on digitization, as well as sharing the developed units as open-educational resources. This article reports on the impact of the first part of the seminar concept, in which the promotion of digitization-related, subject-specific teaching methodology, as well as content-related knowledge (TPaCK) was systematically promoted. In a standardized survey, it could be shown that the prospective teachers demonstrated positive developments, particularly in the components PCK, TCK, TPK, as well as TPaCK, regarding the self-efficacy in cognitive characteristics about one’s own ability within the reference frame of self. Furthermore, the development of knowledge, especially in the areas of TK, PCK, TCK, and TPK, could also be determined, but not in relation to TPaCK itself.
Numerical Integration-Based Performance Analysis of Amplitude-Comparison Monopulse Algorithm in Correlated Noise
Authors: Ham Hyeong-Woo , Lee Joon-Ho
Published: June 2022

In this paper, the performance analysis of the amplitude-comparison monopulse (ACM) algorithm under a correlated noise effect is dealt with. The noise received by a monopulse antenna is caused by various sources, such as jamming, multipath, clutter, and thermal noise. The noise variables caused by these noise sources may be correlated with each other when received by the antenna elements. We explicitly analyzed the angle estimation performance of the monopulse algorithm when a correlated noise is received by deriving the probability density function (PDF) of the channel noise variables. In this process, correlation coefficients between noise variables received by antenna elements are defined, and variance and correlation coefficients of channel noise variables are derived. The performance of the angle estimation is analyzed by calculating the root mean square error (RMSE) for various variances and correlation coefficients of the received noise variables. The expectation operation required for calculating the RMSE is performed via numerical integration. Consequently, the analytically derived RMSE results show excellent agreements with the Monte Carlo simulation-based RMSE result, and it is confirmed that the RMSE decreases as the correlation coefficient between the received noise variables increases. When the SNR is high and on-axis, the RMSE decreases by 20% whenever the correlation coefficient between the reception noise variables increases by 0.2.
Generic and Open-Source Exergy Analysis—Extending the Simulation Framework TESPy
Authors: Witte Francesco , Hofmann Mathias , Meier Julius , Tuschy Ilja , Tsatsaronis George
Published: June 2022

Exergy-based methods support the identification of thermodynamic inefficiencies and the discovery of optimization potentials in thermal engineering applications. Although a large variety of simulation software is available in this field, most do not offer an integrated solution for exergy analysis. While there are commercial products on the market with such capabilities, their access for research and educational purposes is limited. The presented open-source software offers an integrated and fully automated exergy analysis tool for thermal conversion processes. In a first step, physical exergy is implemented, and the tool is then applied to three different example plants to highlight its capabilities and validate the implementation: A solar thermal power plant, a supercritical CO2 power cycle, and an air refrigeration cycle. The respective models and the results of the analyses are presented briefly. By providing the results in modern data structures, they are easily accessible and postprocessible. Future work will include chemical exergy to enable analyses of applications with conversion of matter. Additionally, the implementation of the exergoeconomic analysis and optimization is envisaged.
Geographical Variation in the Growth and Nutritional Traits of Leaf Powder from Broussonetia papyrifera (L.) L’Hér. ex Vent. from Different Provenances
Authors: Zhou Peng , Que Qingmin , Ke Biying , Cui Siming , Chen Xiaoyang , Zhou Wei
Published: June 2022

Broussonetia papyrifera (L.) L’Hér. ex Vent., a perennial deciduous tree, is used in feed, medicine, papermaking, environmental protection, and ecological restoration. This paper ttook 33 provenances from the natural distribution as the research objects, observes their growth and nutritional traits, and analyzes the laws of geographical variation. The repeatability was 0.80–0.88 and 0.48–0.91, respectively. The correlation was significant (the correlation coefficient was 0.764). The variation is greatly affected by the latitudinal direction. Through clustering, the 33 provenances were clustered into 4 groups and most provenances with relatively close geographical origins were clustered together, showing differences between different geographical regions. Using leaf biomass (0.4662 g) and crude protein content (14.39%) as the selection index, the Sichuan Mianyang (SCMY), Chongqing Kaizhou (CQKZ), Shanghai (SH), and Fujian Nanping (FJNP) provenances were selected as fast-growing, high-yield, and high-quality paper mulberry provenances. This study provides the basis for the selection of excellent paper mulberry trees.