bluuebunny/crossref_metadata_2025 huggingface dataset:
Follow-up after emergency laparotomy suggests high one- and five-year mortality with risk stratified by ASA
Authors: Nicoll K , Lucocq J , Khalil T , Khalil M , Watson H , Patil P
Published: September 2021

Introduction

We investigated all-cause mortality following emergency laparotomy at 1 and 5 years. We aimed to establish a basis from which to advise patients and relatives on long-term mortality.

Methods

Local data from a historical audit of emergency laparotomies from 2010 to 2012 were combined with National Emergency Laparotomy Audit (NELA) data from 2017 to 2020. Covariates collected included deprivation status, preoperative blood work, baseline renal function, age, American Society of Anesthesiologists (ASA) grade, operative time, anaesthetic time and gender. Associations between covariates and survival were determined using multivariate logistic regression and Kaplan–Meier analysis. We used patients undergoing laparoscopic cholecystectomy between 2015 and 2020 as controls.

Results

ASA grade was the best discriminator of long-term outcome following laparotomy (n=894) but was not a predictor of survival following cholecystectomy (n=1,834), with mortality being significantly greater in the laparotomy group. Following cholecystectomy, 95% confidence intervals for survival at 5 years were 98–99%. Following laparotomy these intervals were: ASA grade 1, 79–96%; ASA grade 2, 69–82%; ASA grade 3, 44–58%; ASA grade 4, 33–48%; and ASA grade 5, 4–51%. The majority of deaths occurred after 30 days.

Conclusions

Emergency laparotomy is associated with a significantly increased risk of death in the following 5 years. The risk is strongly correlated to ASA grade. Thirty-day mortality estimation is not a good basis on which to advise patients and carers on long-term outcomes. ASA grade can be used to predict long-term outcomes and to guide patient counsel.
Nutritional and lifestyle intervention strategies for metabolic syndrome in Southeast Asia: A scoping review of recent evidence
Authors: Thor Sze Mun , Yau Jun Wern , Ramadas Amutha
Published: September 2021

Metabolic syndrome (MetS) is frequently associated with various health issues and is a major contributor to morbidity and mortality worldwide, particularly with its recent relevance to coronavirus disease 2019 (COVID-19). To combat its increasing prevalence in Southeast Asia, numerous intervention programs have been implemented. We conducted a scoping review on recent interventions to manage MetS among Southeast Asians using standard methodologies. Cochrane, Embase, Ovid MEDLINE, PubMed, and Scopus databases were systematically searched to yield peer-reviewed articles published between 2010–2020. We included 13 articles describing 11 unique interventions in four Southeast Asian countries: Malaysia, Thailand, Indonesia, and Vietnam. These interventions were broadly categorized into four groups: (i) nutrition (n = 4); (ii) physical activity (n = 2); (iii) nutrition and physical activity (n = 2); and (iv) multi-intervention (n = 3). Most studies investigated the effects of an intervention on components of MetS, which are anthropometry, blood pressure, glucose-related parameters, and lipid profile. Significant improvements ranged from 50% of studies reporting serum triglyceride and HDL-cholesterol levels to 100% for waist circumference. Evidence on interventions for individuals with MetS remains limited in Southeast Asia. More studies from other countries in this region are needed, especially on the effects of dietary interventions, to effectively address gaps in knowledge and provide sufficient data to design the ideal intervention for Southeast Asian populations.
Remixing real and imaginary in art education with fully immersive virtual reality
Authors: Paatela-Nieminen Martina
Published: September 2021

This article explores digital material/ism by examining student teachers’ experiences, processes and products with fully immersive virtual reality (VR) as part of visual art education. The students created and painted a virtual world, given the name Gretan puutarha (‘Greta’s Garden’), using the Google application Tilt Brush. They also applied photogrammetry techniques to scan 3D objects from the real world in order to create 3D models for their VR world. Additionally, they imported 2D photographs and drawings along with applied animated effects to construct their VR world digitally, thereby remixing elements from real life and fantasy. The students were asked open-ended questions to find out how they created art virtually and the results were analysed using Burdea’s VR concepts of immersion, interaction and imagination. Digital material was created intersubjectively and intermedially while it was also remixed with real and imaginary. Various webs of meanings were created, both intertextual and rhizomatic in nature.
New records in Brazil reveal a disjunct distribution for Cordia weddellii (Cordiaceae)
Authors: Melo José Iranildo Miranda de , Antar Guilherme M. , Silva Luan Pedro da , Silva Thaynara de Sousa
Published: September 2021

Cordia weddellii, a species of Cordia sect. Cordia (Cordiaceae, Boraginales) endemic to South America is recorded for the first time in Brazil, growing in Cerrado vegetation in Bahia and Tocantins states. A distribution map, photographs, comments on the habitat and phenology, and a preliminary conservation assessment are provided for the species. Additionally, we provide a lectotype for C. weddellii.
Influence of thermal treatment on Anthocyanin, total phenolic content and antioxidant capacity of Pigmented Maize (Zea mays L.)
Authors: Minh Nguyen Phuoc
Published: September 2021

Pigmented maize (Zea mays L.) is a healthy crop due to its perfect proximates and phytochemicals. Thermal treatment was widely used to enhance phytochemical constituents in different kinds of crops. This research evaluated the impact of temperature (100, 115, 130 °C) and duration (10, 15, 20 min) in roasting to anthocyanin, total phenolic content and antioxidant capacity of pigmented maize. Results showed that thermal treatment at 115 °C in 10 min significantly improved anthocyanin in pigmented maize; however, this content would be lower at higher temperatures or prolonged exposing time. Meanwhile, total phenolic content and antioxidant capacity in the pigmented maize were recorded at the highest level when being roasted at 100 oC for 10 min. This research proved that phytochemical constituents and antioxidant capacity inside the pigmented maize would be seriously damaged at high temperatures and extended duration in roasting. By this, producers should pay more attention to thermal conditions in roasting.
Clinical Significance of Angiographically Detectable Neovascularity in Patients with Cardiac Myxoma
Authors: Peng Xiaofan , Xiao Yichao , Guo Yanan , Zhu Zhaowei , Liao Liyan , Liao Xiaobo , Hu Xinqun , Fang Zhenfei , Li Xuping , Zhou Shenghua
Published: September 2021

Background: Myxomas are the most common primary cardiac tumors. Angiographically detectable neovascularity (ADN) of myxoma is increasingly being reported as a result of the use of coronary angiography (CAG) to detect coronary artery disease. However, the clinical significance of these findings is not fully understood.

Methods: We enrolled 59 patients with cardiac myxoma who also underwent CAG between January 2013 and October 2018. Patients were followed up for a mean of 28.9 months (range 1–69 months). The clinical features, echocardiography measurements, pathological examination findings, CAG results, and outcomes during follow-up were compared between patients with ADN and patients without ADN.

Results: ADN was found in 25 patients (42.4%). The arteries feeding the ADN included the right coronary artery (n=15), the left circumflex coronary artery (n=7), and both arteries (n=3). The patients with ADN had a higher proportion of eosinophils (3.2% vs. 2.2%, P=0.03) and higher low-density lipoprotein cholesterol level (2.7 mmol/L vs. 2.2 mmol/L, P=0.02). Myxoma pedicles were more likely to be located in the interatrial septum in patients with ADN (96% vs. 73.5%, P=0.02). No significant correlation was observed between the groups in clinical manifestations, atrial arrhythmia, myxoma size, cardiac chamber size, left ventricular ejection fraction, and the prevalence of complication with coronary artery disease [16% in the ADN group (n=4) vs. 20.6% in the non-ADN group (n=7), P=0.66]. However, patients with ADN tended to have a lower incidence of major adverse cardiac and cerebrovascular events on long-term follow-up (0% vs. 14.7%, P=0.07).

Conclusion: CAG-detected ADN in patients with cardiac myxoma is associated with a borderline lower rate of major adverse cardiac and cerebrovascular events.
Breeding records of Leptotila rufaxilla (Aves: Columbidae) in southwestern Brazilian Amazon with notes on nesting in some regions of occurrence
Authors: Lima Jônatas , Almeida Railene , Guilherme Edson
Published: September 2021

We present new aspects of breeding biology of Gray-fronted Dove Leptotila rufaxilla, from five nests found between 2012 and 2014 in a lowland forest fragment in southwestern Brazil. The nests simple/platform shape were built at a mean height of 1.90 m above ground. The clutch size was two eggs white and elliptic, incubated for 15 days (based on three nests). We recorded predation in two nests still in incubation phase. Minimum hatch weight of nestlings was 10 g and young fledged with a mean mass of 56 g. The constant growth rate (K) of nestlings was 0.40 with a growth asymptote of 60.7 g. Daily survival rate, Mayfield and apparent nesting success in the incubation period was 90, 20 and 56%, respectively, while in the nestling period were all 100%. Our data and the contribution of citizen science showed that L. rufaxilla breeds over the year, mainly in the rainy season, both in southwestern Amazonia and in other regions of occurrence.
Una nueva subespecie de Passiflora lobbii (Passifloraceae) para la vertiente occidental de los Andes peruanos
Authors: Chávez Corcuera Gonzalo Fernando
Published: September 2021

Se describe Passiflora lobbii subsp. limensis Chávez-Corcuera que se distingue del resto de subespecies de Passiflora lobbii por presentar dos ocelos en la cara abaxial de la lámina, pecíolos con glándulas situadas en su zona media y láminas foliares de mayores dimensiones que el resto. Adicionalmente, se presenta una clave para la determinación de las subespecies de P. lobbii y otros taxones afines, acompañada de una tabla comparativa con los caracteres morfológicos foliares de las subespecies de Passiflora lobbii.
First record of Pachybrachis Chevrolat, 1836 (Coleoptera: Chrysomelidae: Cryptocephalinae) on Spermacoce verticillata L. (Rubiaceae) and synthesis of its plant associations in Brazil
Authors: Duarte-de-Mélo Jefferson , Cajé Suianne Oliveira dos Santos , Lima Iracilda Maria de Moura
Published: September 2021

This study reports Pachybrachis sp. association with a new host, Spermacoce verticillata L. (Rubiaceae). It synthesizes Brazil locality records and host plant records from literature. Specimens of adults and larvae were collected on the host in an urban area of Maceió, Alagoas, Brazil. Larvae and adults were reared on the host plant in the laboratory, using fresh plant tissue daily.
Estación Biológica Quebrada Blanco
Authors: Heymann Eckhard W. , Tirado Herrera Emérita Rosabel
Published: September 2021

La Estación Biológica Quebrada Blanco (EBQB), en el nororiente de la Amazonía peruana, es un lugar donde se ha venido realizando investigación científica desde 1984. En sus inicios la investigación se enfocaba en la ecología y el comportamiento de primates; sin embargo, también se suman trabajos sobre inventarios de algunos grupos de árboles (>10 cm DAP), helechos y aves. El área de la EBQB es muy poco perturbada y está ubicada en una zona de alta biodiversidad. En este trabajo resumimos su historia, la información sobre biodiversidad de que se dispone y mostramos a la EBQB como un lugar con alto potencial para futuros estudios en biodiversidad y ecología en un amplio espectro de organismos.
Breeding biology and biometrics of Myiozetetes c. cayanensis (Aves: Tyrannidae) in southwest Brazilian Amazonia with breeding season in Brazil
Authors: Lima Jônatas , Guilherme Edson
Published: September 2021

Our study provides information on the breeding and biometrics of Rusty-Margined Flycatcher Myiozetetes cayanensis in southwest Brazilian Amazonia. Myiozetetes cayanensis is distributed from Central America until north of South America. We made observations on reproduction and captures of this species in a terra firme forest fragment in the state of Acre, between 1999 and 2020 and we evaluated the breeding season in Brazil through citizen science data. We monitored nine nests between 2012 and 2020, built at a mean height of 1.8 m above ground. Clutch size was two, three or four eggs, incubated for 15 days. We monitored the development of six nestlings: minimum hatch weight was 2 g and young fledged with a mean mass of ca. 25.5 g. The constant growth rate (K) of nestlings was 0.18 with a growth asymptote of 22.8 g. Daily survival rate was 90% and 100% during the incubation and nestling periods, respectively. The Mayfield success in the incubation and nestling periods was 20 and 100%, respectively. Apparent nesting success in the incubation and nestling periods was 46 and 100%, respectively. We recorded a minimum longevity of 2 years, nine months and 26 days. The subspecies M. c. cayanensis start to nest mainly between the dry and rainy season in Brazil, overlapping with the molt period in southwest Amazonia.
First nest records, nestling growth and morphometrics of Dendroplex picus peruvianus (Aves: Dendrocolaptidae) in southwestern Brazilian Amazon
Authors: Lima Jônatas , Guilherme Edson
Published: September 2021

We reported the first data on the breeding and growth in Dendroplex picus peruvianus from a forest fragment in southwestern Amazonia. We observed and netted this species between 1999 and 2019. We found two active nests in 2012 and 2013, but we monitored only one. Clutch size was two eggs, incubated for 16 days. The constant growth rate (K) of nestlings was 0.31 with a growth asymptote of 46.3 g. We recorded a longest minimum longevity of eight years. Our records showed that D. p. peruvianus breeds mainly in the rainy season (September–March) overlapping with the molt period.
Resource partitioning between Microlophus occipitalis and Stenocercus puyango (Sauria: Tropiduridae) in Cerros de Amotape National Park, Tumbes, Peru
Authors: Guzmán Alfredo , Jordán Juan Carlos
Published: September 2021

Activity, microhabitat use, and diet are patterns commonly used to define the saurian community structure, because of differential exploitation allowing coexistence at the same time and place. We analyze resource partitioning between two sympatric saurian species, Stenocercus puyango and Microlophus occipitalis, in the transitional area of the Pacific Tropical Forest and the Dry Forest inside Cerros de Amotape National Park (PNCA) in Tumbes, northwestern of Peru. Microlophus occipitalis and S. puyango both showed a unimodal activity pattern with higher activity around 13:00 h, with a mean body temperature of 34.83 °C and 32.17 °C respectively, observing a significant relationship between body and environmental (air and substrate) temperatures. Rocks and tree trunks were the most frequent microhabitats used by M. occipitalis while S. puyango were registered more frequently over leaf litter. The diets of both tropidurids were composed by arthropods, ants, and insect larvae mainly. Similarities in activity times (temporal niche) and diet (trophic niche) should be related to phylogenetic relationship and environmental characteristics of PNCA (seasonality, vegetal composition) meanwhile differences in space use and microhabitat thermal quality will be related to thermal quality in the area.
Ampliación de la distribución geográfica y estado de conservación de Ctenoblepharys adspersa (Tschudi, 1845)
Authors: Ormeño Jesús R. , Sumiano-Mejia Ronal , Orellana-Garcia Alfonso , Whaley Oliver Q. , Pérez Z. José , Venegas Pablo J.
Published: September 2021

Ampliamos la distribución geográfica de Ctenoblepharys adspersa (Liolaemidae), una especie de saurio endémico y amenazado del desierto peruano. Nuestro nuevo registro extiende la distribucion de esta especie en 60 km (línea recta) de la localidad más oriental previamente conocida, la Reserva Nacional de Paracas. Registramos dos tipos de hábitat nuevos para C. adspersa al interior de las estribaciones andinas e identificamos las plantas nativas asociadas a sus hábitats. Además, revisamos el estado de conservación de esta especie y los desafíos que implican su conservación, resaltando que la mayoría de las poblaciones son vulnerables a los impactos en su hábitat producto del desarrollo de infraestructura urbana y/o agrícola
Formación de un humedal en la costa norte del Perú
Authors: Díaz Aníbal , Sáenz-Zúñiga Lisset , Zutta Brian
Published: September 2021

Se describe, analiza y reporta por primera vez la formación de un humedal costero en el sur de Salaverry (La Libertad, Perú). Se realiza la comparación del número de especies con otros humedales ubicados en áreas costeras de la región, empleando para ello imágenes satelitales de acceso público e información biológica. Se obtuvo una serie de tiempo suficiente para plantear una hipótesis sobre su formación, calculando el NDVI (Índice de Vegetación de Diferencia Normalizada) y NDMI (Índice de Humedad de Diferencia Normalizada) para confirmar su estabilidad e influencia. El resultado del análisis sugiere que el humedal sur de Salaverry se formó hace quince años por dos aportes antrópicos: filtraciones de agua dulces desde terrenos agrícolas y agua de mar usada para el bombeo del material dragado en las inmediaciones del Puerto de Salaverry. Por sus características ecosistémicas, el humedal se encontraría en las primeras etapas de sucesión ecológica, y a pesar de origen espontáneo, estaría operando como una laguna costera salobre que atrae fauna oportunista, principalmente aves.
Carotid artery elongation (dolichoarteriopathy) and cerebral perfusion: results of a pilot study
Authors: Golovin D. A. , Rostovtseva T. M. , Kudryavtsev Yu. S. , Berdalin A. B. , Lelyuk S. E. , Lelyuk V. G.
Published: September 2021

Among the causes of brain ischemia, including stroke, the impaired straightness of internal carotid arteries (ICAs) are considered. The article discusses modern views on the causes of ICA geometry disorders, their pathogenetic and hemodynamic significance, and a possible contribution to cerebral lesions.

Aim. To study the relationship between the anomalies of ICA configuration and the brain perfusion parameters using cerebral multislice computed tomographic angiography.

Material and methods. Seventeen patients after ischemic stroke who had ICA elongation on the contralateral side of infarction: 7 women aged 60-87 years (median [1st quartile; 3rd quartile]: 73 [64; 75]) and 10 men aged 54-80 years (62 [60; 73]). There were also 10 patients of the control group with normal ICA configuration on the contralateral side of infarction: 5 women aged 50-71 years (59 [50; 68]) and 5 men aged 55-81 years (58 [57; 62]). Brain multislice computed tomographic angiography and magnetic resonance imaging were performed. Results. A significant perfusion decrease within normal values in the blood systems of the elongated ICAs was established. The relationship between the degree of ICA elongation and the age of patients, in the absence of such for brain white matter lesions, was recorded. There is the need to continue the study to clarify the nature of the severity and causes of the revealed phenomena.
Acute coronary syndrome in COVID-19 patients
Authors: Chashchin M. G. , Gorshkov A. Yu. , Drapkina O. M.
Published: September 2021

Acute coronary syndrome (ACS) is caused by an acute mismatch between myocardial oxygen demand and its supply. This mechanism is largely associated with the progression of coronary atherosclerosis in combination with an inflammatory response, hypoxemia, and blood procoagulation. Patients with the coronavirus disease 2019 (COVID-19), aggravated by cardiovascular diseases and comorbidities, are at high risk of ACS.

Aim. To analyze the publications, which reflects the development of ACS in patients with COVID-19, its pathogenesis, and clinical course. Material and methods. Literature data were searched using Google Scholar, PubMed, ScienceDirect, and Cyberleninka services. The analysis included data from clinical guidelines on COVID-19, data from clinical studies, reports, and systematic reviews.

Results. This literature review summarizes and systematizes the data presented in modern publications, highlights the aspects of the clinical course and pathogenetic mechanisms underlying ACS in patients with COVID-19.

Conclusion. The pathogenesis of COVID-19 is inextricably associated with the widespread cytopathic effect of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), uncontrolled immune response that causes systemic inflammation, as well as the coagulation system activation. In patients with COVID-19, along with the atherosclerosis, these mechanisms significantly increase the risk of ACS and can worsen its in-hospital course.
COVID-19 as a cause of chronic pulmonary hypertension: pathophysiological rationale and potential of instrumental investigations
Authors: Kobelev E. , Bergen T. A. , Tarkova A. R. , Vasiltseva O. Ya. , Kamenskaya O. V. , Usov V. Yu. , Chernyavsky A. M.
Published: September 2021

Coronavirus disease 2019 (COVID-19) is a poorly understood and dangerous medical problem. COVID-19-related pulmonary vessels involvement is a complex set of interrelated pathophysiological processes associated with vascular endothelial dysfunction and accompanied by thrombosis of various localization, vasomotor disorders, severe respiratory failure, as well as pulmonary embolism (PE) resulting in chronic thromboembolic pulmonary hypertension (CTEPH). According to computed tomographic pulmonary angiography, the incidence of PE in patients with COVID-19 ranges from 23 to 30%. The aim of this work was to focus the doctors' attention on the risk of pulmonary hypertension in patients after COVID-19.

Despite the ability of severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) to infect various organs and systems, the main and most serious complications are pulmonary infiltration, acute respiratory distress syndrome, acute respiratory failure and PE, which in some cases becomes the triggering mechanism for CTEPH development. The literature review presents data on main pathological abnormalities developing in target organs during COVID-19 and playing an important role in increasing the CTEPH risk. The paper describes the main methods of instrumental investigations of CTEPH and an algorithm for its use in COVID-19 survivors.

The revealed data demonstrated that the absence of obvious signs of pulmonary hypertension/CTEPH, the cardiopulmonary system abnormalities cannot be ruled out. Therefore, it seems appropriate to actively follow up COVID-19 survivors. A thoroughly, purposefully collected anamnesis, pulmonary function tests and stress echocardiography in an ambiguous clinical situation will play a leading role as they identify cardiopulmonary disorders and provide the doctor with basic information for further planning of patient management.
Is brown adipose tissue a new target for obesity therapy?
Authors: Drapkina O. M. , Kim O. T.
Published: September 2021

The rapid increase in the prevalence of obesity and related diseases has prompted researchers to seek novel effective therapeutic targets. Recently, brown adipose tissue has been in the spotlight as a potential target for treatment of metabolic diseases due to its ability to increase energy expenditure and regulate glucose and lipid homeostasis. The review presents the latest data on approaches aimed at activating and expanding brown adipose tissue in order to combat obesity.
Health benefits of aerobic exercise: known mechanisms and research potential
Authors: Begrambekova Yu. L. , Orlova Ya. A.
Published: September 2021

The pandemic of noncommunicable diseases, which is currently one of the main threats to health and well-being of mankind, makes us look for ways to prevent their development early. Low cardiorespiratory endurance due to a sedentary lifestyle is associated with high cardiovascular risk, all-cause and cancer mortality. Skeletal muscles are the most important secretory organ and is characterized by outstanding metabolic performance and endurance. Exercise-induced low-dose stress contributes to mitochondrial biogenesis and remodeling of not only the muscular system, but also other systems involved in maintaining muscle activity, including regulating glucose and fat metabolism, maintaining immunity, and stimulating angiogenesis. These and other effects of physical activity are implements through the myokine system discovered in recent years. Shutting off the paracrine, exocrine and endocrine functions of muscles cannot be replenished in any other way and leads to disruption of vital adaptive processes. This review describes currently available evidence of unique role of aerobic physical activity in maintaining the human health, as well as to define the chain of pathological reactions during physical inactivity. The search was carried out in the Medline and PubMed Central databases for the keywords: cardiorespiratory endurance, non-communicable diseases, maximum oxygen consumption, myokines, interleukin-6, aerobic exercise.
Role of biobanking in managing large-scale epidemiological studies
Authors: Pokrovskaya M. S. , Borisova A. L. , Metelskaya V. A. , Efimova I. A. , Doludin Yu. V. , Kozlova V. A. , Serebryanskaya Z. Z. , Balanova Yu. A. , Meshkov A. N. , Pustelenin A. V. , Imaeva A. E. , Shalnova S. A. , Kontsevaya A. V. , Drapkina O. M.
Published: September 2021

The success and quality of large-scale epidemiological studies depends entirely on biomaterial quality. Therefore, when arranging the third Epidemiology of Cardiovascular Diseases and their Risk Factors in Regions of Russian Federation (ESSE-RF-3) study, increased attention was paid to specifics of collection, processing and further transportation of biological samples and related clinical and anthropometric data of participants from regional collection centers to Biobank.

Aim. To develop a methodology for collection of high-quality biomaterials within the large-scale epidemiological study, involving the sampling, processing, freezing of blood and its derivatives (serum, plasma) in the regions, followed by transportation and storage of obtained biomaterial in the Biobank of National Medical Research Center for Therapy and Preventive Medicine (Moscow).

Material and methods. To conduct the ESSE-RF-3 study, a design was developed, according to which the collection of venous blood samples in a total volume of 29,5 ml from each participant is planned in all participating regions in order to obtain and store samples of whole blood, serum and two types of plasma.

Results. On the basis of international biobanking standards, ethical norms, experience from ESSE-RF and ESSE-RF-2, and literature data, a protocol for biobanking of blood and its derivatives was developed. The type and number of serum and plasma aliquots obtained, the required standard technical means and consumables, as well as logistic biomaterial requirements were determined. Training programs for regional participants were developed. By the beginning of August 2021, 180 thousand samples of whole blood, serum and plasma from more than 23 thousand participants from 28 Russian regions were collected, processed and stored.

Conclusion. The presented work made it possible to assess and confirm the compliance of developed biobanking protocol with quality requirements. However, due to the coronavirus disease 2019 pandemic, by August 2021, the Biobank did not reach the maximum effectiveness predicted for the ESSE-RF-3 project.
Antiarrhythmic therapy for atrial fibrillation: current guidelines of the European Society of Cardiology and the European Association for Cardio-Thoracic Surgery (ESC/EACTS)
Authors: Tarzimanova A. I. , Doshchitsin V. L.
Published: September 2021

The treatment of atrial fibrillation (AF) remains one of the most difficult tasks in modern cardiology. In 2020, the European Society of Cardiology (ESC), together with the European Association for Cardio-Thoracic Surgery (EACTS), published guidelines for the diagnosis and management of AF, which include several new directives.

ESC experts have formulated a novel concept for treatment of AF patients. The first component of treatment ‘A' (Anticoagulation/ Avoid stroke) is anticoagulant therapy in patients with increased risk of thromboembolic events. The second line of treatment ‘B' (Better symptom control) is the control of arrhythmia symptoms, selection of a rhythm control strategy or ventricular rate control. The third direction ‘C' includes cardiovascular risk factors and comorbid conditions management.

The most challenging tasks in AF treatment are the control of arrhythmia symptoms. As in the previous version of 2016 guidelines, the latest ones identify 2 following strategies in treatment of AF: rhythm control and ventricular rate control.

According to the current ESC/EACTS guidelines (2020), antiarrhythmic therapy continues to be one of the important directions in AF management. Early prescription f antiarrhythmic and anticoagulant agents with an increased risk of thromboembolic events, catheter ablation can not only improve the quality of life, but also the prognosis of patients with AF.
Effect of regional living conditions on middle-term cardiovascular outcomes: data from prospective stage of the ESSE-RF study
Authors: Maksimov S. A. , Shalnova S. A. , Kutsenko V. A. , Balanova Yu. A. , Muromtseva G. A. , Kapustina A. V. , Evstifeeva S. E. , Imaeva A. E. , Karamnova N. S. , Drapkina O. M.
Published: September 2021

Aim. To assess regional living conditions with cardiovascular outcomes based on prospective stage of the Epidemiology of Cardiovascular Diseases and their Risk Factors in Regions of Russian Federation (ESSE-RF) study.

Material and methods. We used data from a 3- and 5-year prospective stage of the ESSE-RF study (2012-2013). For initial screening, 16210 people aged 25-64 were included. To characterize the regions of residence, 5 regional indices (RIs) were used. The following endpoints were considered: cardiovascular death, myocardial infarction, stroke, composite endpoint (cardiovascular death + myocardial infarction + stroke). To assess the correlations, generalized estimating equations with nested data structure (individuals in the regions) were used. The studied associations were adjusted for a wide range of potential effect modifiers.

Results. There are multiple direct associations of RIs with the likelihood of all endpoints. The exception was the reverse association of Industrial RI with cardiovascular death. The most stable associations regarded Mixed RI, Industrial RI and Socio-geographical RI, with a high RI significance in endpoint development, compared with well-known individual cardiovascular risk factors. Separate associations were noted for Economic RI and Demographic RI.

Conclusion. The results indicate a significant contribution of a number of regional living conditions to individual risk of fatal and non-fatal cardiovascular outcomes.
Contribution of cardio-ankle vascular index to prediction of cardiovascular events in the adult urban population: data from the ESSE-RF study (Tomsk)
Authors: Zairova A. R. , Rogoza A. N. , Oshchepkova E. V. , Yarovaya E. B. , Kutsenko V. A. , Shalnova S. A. , Trubacheva I. A. , Kaveshnikov V. S. , Serebryakova V. N. , Boytcov S. A.
Published: September 2021

Aim. To determine the role of cardio-ankle vascular index (CAVI) in predicting cardiovascular events (CVEs) in adult Russian population using model of the Epidemiology of Cardiovascular Diseases and their Risk Factors in Regions of Russian Federation (ESSE-RF) study (Tomsk).

Material and methods. We analyzed the data of 1342 people aged 25-64 (4,3±11,6) years, in whom arterial stiffness was assessed as part of the ESSE-RF study using the vascular screening system VaSeraVS-1500, followed by phone contacts, on average, 4,7 years later. We studied the prognostic role of CAVI in relation to primary composite (cardiovascular death, nonfatal myocardial infarction (MI) or stroke) and secondary composite (all CVEs) endpoints.

Results. We revealed that prior myocardial infarction or stroke (n=52) is associated with an increase in CVE incidence from 2,3 to 11,5% (p=0,0003) and from 5% to 23% (p<0,001) for primary and secondary composite endpoints, respectively. In a group of 1290 people (without prior MI or stroke), CAVI was significantly higher in men than in women: 7,4±1,4 vs 7,1±1,3 (p=0,002), despite more young age: 45,4±11,8 vs 48,0±11,3 years (p<0,001). The risk criterion for CVE was CAVI >7,8 (relative risk (RR): 5,06; 95% confidence interval (CI): 2,32-11,06) (p<0,001) and (RR: 3,95; 95% CI: 2,37-6,58) (p<0,001), which retains its predictive value when adjusted for conventional risk factors (RR: 3,13; 95% CI: 1,26-7,75) (p=0,014) and (RR: 2,16; 95% CI: 1,18-3,98) (p=0,013) — primary and secondary composite endpoints, respectively.

Conclusion. CAVI has a significant independent value in predicting CVEs in Tomsk adult urban population aged 25-64 years. To clarify the cardiovascular risk, vascular screening with identifying CAVI should be carried out during preventive and screening examinations for men over 35 and women over 45.
Unhealthy diet in association with abdominal obesity as risk factors for cardiovascular disease: data from the ESSE-RF2 study in the Omsk region
Authors: Viktorova I. A. , Moiseeva M. V. , Stasenko V. L. , Shirlina N. G. , Livzan M. A.
Published: September 2021

Aim. To compare dietary patterns of the Omsk region male and female representatives with and without abdominal obesity (AO).

Material and methods. Wthin the second study of Epidemiology of Cardiovascular Diseases and their Risk Factors in Regions of Russian Federation (ESSE-RF2) using a representative sample of Omsk region population aged 25-64 years (n=1648), dietary habits, including 21 food groups, were assessed by the questionnaire method. Eating habits of Omsk region representatives with (n=936) and without AO (n=712) were compared.

Results. Insufficient consumption of vegetables and fruits practically does not differ in those with or without AO. Depending on sex, insufficient fruit consumption is more typical for both men and women without AO. In addition, there is insignificant increase of fruit consumption in AO people, especially women (p=0,09). Both men (p=0,05) and women (p=0,045) are less likely to consume meat daily but more often consume fish weekly compared to those without AO. This mainly applies to women, because women with AO, in contrast to those without AO, are significantly less likely to consume insufficient amount of fish (p=0,0001). Compared to women with, men with AO significantly more often daily and weekly consume seafood (p=0,001). Daily milk consumption is much less common in individuals with AO, but only at the expense of men with AO (p=0,0001). Kefir and yogurt, on the contrary, are more often consumed in patients with AO both daily and weekly. Omsk people with AO are less likely to introduce yogurt into their daily diet, mainly at the expense of women with AO (p=0,02). Excessive consumption of pasta is more typical for persons without AO (p=0,0001), and by means of men (p=0,001). Omsk residents with AO more often exclude the sweets and confectionery from diet. In the daily diet, they are much less common in individuals with AO (p=0,0001), especially in men with AO (p=0,0001). The respondents with AO daily consume pickles 1,4 times more often compared with those without AO, and mainly by means of men (p=0,03).

Conclusion. Presence of AO somewhat changed the dietary habits of Omsk residents. AO patients are less likely to consume pasta, sweets and confectionery products, but more likely to eat pickles and to add more salt to cooked food, which requires targeted preventive measures, taking into account the identified sex priorities, depending on AO presence.
Associations of eating and drinking habits with cardiovascular disease and diabetes in the adult population: data from the ESSE-RF epidemiological study
Authors: Karamnova N. S. , Rytova A. I. , Shvabskaya O. B. , Makarova Yu. K. , Maksimov S. A. , Balanova Yu. A. , Evstifeeva S. E. , Imaeva A. E. , Kapustina A. V. , Muromtseva G. A. , Shalnova S. A. , Drapkina O. M.
Published: September 2021

The presence of a disease, the prognosis of which can be improved by dietary modification, motivates a patient to change their eating habits.

Aim. To study the associations of dietary patterns and alcohol consumption with cardiovascular diseases (CVDs), diabetes, myocardial infarction (MI), and stroke in the adult population.

Material and methods. The analysis was carried out using data from representative samples of population from 13 Russian regions aged 2564 years (n=19520; men, 7329; women, 12191). The response rate was ~80%. Dietary characteristics were assessed by frequency method.

Results. In the diet of people with CVDs, the daily intake of vegetables/ fruits increases by 84% in men and by 19% in women, while the use of animal fats in cooking decreases by 28% and 20%m respectively (p<0,0001). Women with CVDs reduce the consumption of processed meat and sweets by 16 and 19%, respectively (p<0,005). Persons with prior MI reduce the consumption of sweets in the diet: men by 38% and women by 30%. Men with prior MI have higher daily consumption of cereals by 31%, vegetables and fruits by 46%, low-fat dairy products — 2,4 times. In addition, they are more adherent to a healthy and cardioprotective diet by 3,65 and 1,75 times, respectively. Dietary changes in those with prior stroke were noted only in women in the form of a 29% decrease in excess salt intake (p=0,0075). In the diet of people with diabetes, there is decreased consumption of sweets and an increased intake of vegetables/fruits: by 77 and 69% in men and by 79 and 69% in women, respectively (p<0,0001). Men with diabetes are 3 times more likely to adhere to a healthy diet, and women — 2,3 times (p=0,0039 and p<0,0001, respectively).

Conclusion. Patients with CVDs, MI, and diabetes have a healthier diet than healthy persons.
ESSE-RF study: epidemiology and public health promotion
Authors: Kontsevaya A. V. , Shalnova S. A. , Drapkina O. M.
Published: September 2021

The largest population-based study in Russian modern history the Epidemiology of Cardiovascular Diseases and their Risk Factors in Regions of Russian Federation (ESSE-RF) for 8 years has become a platform for public health research and projects, relevant for the whole country. Results of the ESSE-RF study were used to identify Demography National Project parameters, to model mortality and morbidity risk at the population level, to estimate the economic burden of risk factors, to predict the economic effect of population prevention measures, to assess the feasibility of using novel biomarkers for risk stratification, as well as for external evaluation of health care system. Further, results can be used to develop a novel cardiovascular risk score, to analyze COVID-19-related risk factors, and to study health protection environment. Epidemiological studies ESSE-RF1 and ESSE-RF2 have already become a significant component of public health system in Russia, and taking into account the scope of the ESSE-RF3 study (30 regions), the role of epidemiology will increase.
Prevalence of carotid and femoral artery atherosclerosis among the Ivanovo Oblast population: data from the ATEROGEN-Ivanovo study
Authors: Ershova A. I. , Balakhonova T. V. , Meshkov A. N. , Kutsenko V. A. , Yarovaya E. B. , Shalnova S. A. , Lishchenko N. E. , Novikova A. S. , Aleksandrova E. L. , Shutemova E. A. , Belova O. A. , Rachkova S. A. , Boytsov S. A. , Drapkina O. M.
Published: September 2021

Aim. To study the prevalence of carotid (CA) and femoral artery (FA) atherosclerosis among Russian population, mainly in middle age group, using a representative sample of one of the Central Russian regions.

Material and methods. The analysis included participants of the ATEROGEN-Ivanovo study (sub-study of the ESSE-RF conducted in the Ivanovo region) aged 40-67 years, who were invited for CA and FA ultrasound to assess plaque presence. A total 1102 people were examined, which was >80% of the original sample.

Results. The age of subjects was 54 [48; 60] years (men, 28%). Only 11,2% of participants took statins; 30,9% had low cardiovascular risk (CVR), 35,6% — moderate CVR, 21,8% — high CVR, and 11,8% — very high CVR. The incidence of at least one plaque in CA or FA was 73,6%. The prevalence of CA atherosclerosis was 76,4% in men and 59,1% in women, FA atherosclerosis — 54,9% and 28,3%, respectively. Furthermore, plaques were detected already at the age of 40. The incidence of plaques significantly increased with age, with the exception of carotid atherosclerosis in men, a significant increase in the incidence of which stopped at 45 years of age.

Conclusion. Among the Ivanovo population aged 40-67 with a predominance of low-to-moderate CVR patients, there is a high prevalence of carotid and femoral atherosclerosis, which indicates a high potential for using ultrasound for diagnosing subclinical atherosclerosis in assessing CVR in people of this age range.
Associations of increased spatial QRS-T angle with cardiovascular risk factors: data from the regional sample of ESSE-RF study
Authors: Muromtseva G. A. , Aidu E. A.-I. , Makarova Yu. K. , Kutsenko V. A. , Yarovaya E. B. , Trunov V. G. , Balanova Yu. A. , Kapustina A. V. , Evstifeeva S. E. , Efanov A. Yu. , Shalnova S. A. , Drapkina O. M.
Published: September 2021

Aim. To study the associations of increased spatial QRS-T angle (sQRS-Ta ≥90°) with cardiovascular risk factors (RFs).

Material and methods. We analyzed 1411 electrocardiography (ECG) records of men and women aged 25-64 years from a random regional sample of the Epidemiology of Cardiovascular Diseases and their Risk Factors in Regions of Russian Federation (ESSE-RF) study. Relationships of sQRS-Ta with the following RFs were assessed: hypertension (HTN), systolic blood pressure (SBP) ≥140 mm Hg, diastolic BP (DBP) ≥90 mm Hg, pulse pressure (PP) ≥60 mm Hg; glucose ≥7,0 mmol/l, hypercholesterolemia; hypertriglyceridemia; high-density lipoprotein cholesterol (HDL-C) ≤1,0/1,2 mmol/l in men/women, low-density lipoprotein cholesterol (LDL-C) >3,0 mmol/l; C-reactive protein (CRP) >1 mg/L; overweight, obesity and abdominal obesity; heart rate (HR) >80 bpm; age >52 years.

Results. Weak but significant correlations of sQRS-Ta with age (in women), SBP, DBP, PP, body mass index, waist circumference, lipids, glucose, CRP were revealed. Univariate logistic regression demonstrated significant associations of increased sQRS-Ta with HTN, elevated SBP and PP, overweight, obesity and abdominal obesity, hypercholesterolemia, elevated LDL-C and CRP, hyperglycemia, age >52 years and heart rate >80 bpm. There were no associations of increased sQRS-Ta with male sex, elevated DBP, smoking, hypertriglyceridemia, and low HDL-C levels. The sQRS-Ta associations characteristic of women was similar with associations found among the entire sample. Men with increased sQRS-Ta had no associations with any of analyzed RFs. In multivariate models, increased sQRS-Ta was associated with the following combination of RFs: age >52 years, heart rate >80 bpm, HTN, increased PP, overwaight, and male sex. According to direct stepwise selection among all subjects and in women, the main contribution to sQRS-Ta was made by SBP, age, HDL-C and heart rate.

Conclusion. Despite the significance of stepwise regression model (p=0,0001), the low coefficient of determination R2may indicate other not yet identified determinants with relevant associations with sQRS-Ta.
Contribution of hypertension and other risk factors to survival and mortality in the Russian population
Authors: Balanova Yu. A. , Shalnova S. A. , Kutsenko V. A. , Imaeva A. E. , Kapustina A. V. , Muromtseva G. A. , Evstifeeva S. E. , Maksimov S. A. , Karamnova N. S. , Yarovaya E. B. , Kulakova N. V. , Kalachikova O. N. , Chernykh T. M. , Belova O. A. , Artamonova G. V. , Indukaeva E. V. , Grinshtein Yu. I. , Libis R. A. , Duplyakov D. V. , Rotar O. P. , Trubacheva I. A. , Serebryakova V. N. , Efanov A. Yu. , Konradi A. O. , Boytsov S. A. , Drapkina O. M.
Published: September 2021

Aim. To study the contribution of hypertension (HTN) to survival and mortality in the Russian population.

Material and methods. This prospective observational cohort included representative samples from 11 Russian regions (men and women aged 25-64 years, n=18251) examined in 2012-2014 as part of the Epidemiology of Cardiovascular Diseases and their Risk Factors in Regions of Russian Federation (ESSE-RF) study. The examination included a questionnaire (12 modules), anthropometric and blood pressure (BP) measurements, as well as biochemical blood tests. HTN was considered aa a systolic BP ≥140 mm Hg and/or diastolic BP ≥90 mm Hg, or when a subject receives antihypertensives. Treatment efficacy was considered as the proportion of persons (%) who achieved target BP among those taking antihypertensives. Depending on HTN status, all participants were divided into 4 groups: 1) those without HTN;

2)        those with HTN, taking antihypertensive agents and having systolic BP ≤140 mm H. and diastolic BP ≤90 mm Hg (effective therapy);

3)        those with HTN, taking medications, but not achieving target BP (ineffective therapy); 4) those with HTN, not taking antihypertensives. The life status of participants was updated every 2 years. Kaplan-Meier survival curves, as well as univariate and multivariate Cox proportional hazards models were created.

Results. The presence of HTN significantly reduced survival (p<0,001) in the cohort, which is significant when adjusted for age (men — relative risk (RR)=1,47, p<0,001, women — RR=1,17, p<0,001). In the multivariate model, the male sex (RR=2,3 p<0,001), age increase, smoking, tachycardia, and HTN are significant for all-cause mortality only for men, but not for women. However, for women, absence of higher education was significant. The presence of HTN significantly worsens cardiovascular survival in both sexes (p<0,0001). HTN increases the risk of a composite endpoint for both men and women (p<0,001). Analysis of Kaplan-Meier curves showed the worst survival rate in persons with HTN, taking antihypertensive drugs, but not reaching target BP levels.

Conclusion. The presence of HTN significantly worsens the survival rate of men and women. Special attention of medical community should be directed to increasing the proportion of effectively treated patients with HTN.