bluuebunny/crossref_metadata_2025 huggingface dataset:
The impact of healthcare industry convergence on the performance of the public health system: a geospatial modeling study of provincial panel data from China
Authors: Li Wei , Zhu Ke , Liu Echu , Peng Wuzhen , Fang Cheng , Hu Qiong , Tao Limei
Published: September 2023

Objective

This paper examines the impact of healthcare industry convergence on the performance of the public health system in the eastern, central, and western regions of China.

Methods

Public health performance was measured by a composite index of three standards: average life expectancy at birth, perinatal mortality, and maternal mortality. The healthcare industry convergence was measured using a coupling coordination degree method. The spatial lag, spatial error, and spatial Durbin models were used to estimate the effect of healthcare industry convergence on public health system performance and this effect’s spatial dependence and heterogeneity across eastern, central, and western China using panel data from 30 Chinese provinces from 2002 to 2019.

Results

The convergence of the healthcare industry significantly promotes regional public health [β =0.576, 95% CI: (0.331,0.821)]. However, the convergence does not have a spatial spillover effect on the public health system at the national level. Additionally, analysis of regional heterogeneity shows that the direct effects of healthcare industry convergence on public health are positive and statistically significant for Eastern China, statistically insignificant for Central China, and positive and statistically significant for Western China. The indirect effects are negative, statistically significant, positive, statistically significant, and statistically insignificant for these three regions, respectively.

Conclusion

Policy efforts should strengthen the convergence between the healthcare industry and relevant industries. It can produce more current healthcare services to improve public health and reduce regional health inequality.
Mind-body practice as a primer to maintain psychological health among pregnant women–YOGESTA–a randomized controlled trial
Authors: Nadholta Pooja , Kumar Krishan , Saha Pradip Kumar , Suri Vanita , Singh Amit , Anand Akshay
Published: September 2023

Objective

The objective of this study was to investigate the impact of Gestational Yoga-YOGESTA (Gestational Yoga), on the neuropsychology, quality of life, and personality of pregnant women.

Design

Open label, randomized controlled trial, used allocation concealment to allocate the treatment.

Setting

Department of Obstetrics and Gynecology and Neuroscience Research Lab, Department of Neurology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Participants

We recruited a total of 100 pregnant women visiting the Outpatient Department of Obstetrics and Gynecology. Participants were aged between 18 and 35 with uncomplicated pregnancies and they were randomly assigned to either the Yoga group (YG) or the usual care group (UCG). A total of 77 pregnant women completed both the pre- and post-survey, with 34 participants in the Yoga group and 43 in the Usual care group.

Intervention

Pregnant women in their second and third trimesters were provided with a 16-week online Prenatal Yoga intervention. The intervention began after enrollment in the 2nd trimester, specifically between the 16th and 20th week, and was conducted 5 days a week until delivery, with an average intervention period of 47.18 ± 2.031 (mean ± SEM) days.

Chief outcome measures

We measured Perceived stress, Depression, Anxiety, Stress, and quality of life by using standard questionnaires.

Results

A total of 77 participants were included in the analysis, with 34 assigned to the Yoga group and 43 assigned to the control group. Most of the measured parameters demonstrated significant changes. The Yoga group exhibited a noteworthy decrease in perceived stress, depression, anxiety, and psychological stress, as well as an improvement in the psychological and environmental domains of QOL-BREF. Conversely, the control group demonstrated a significant increase in perceived stress, depression, anxiety, and psychological stress, along with a reduction in the physical, psychological, and social domains of QOL-BREF at the follow-up stage. Although the two groups were similar at baseline, the Yoga group showed substantial enhancements in perceived stress, depression, anxiety, physiological stress, and overall quality of life when compared to the control group at follow-up.

Conclusion

The study’s findings indicate that stress, anxiety, and depression are more likely to occur as gestational age progresses during pregnancy. Nevertheless, practicing Prenatal Yoga can effectively manage these changes and enhance the quality of life for expectant mothers.

Clinical trial registration: Clinical Trials Registry-India, Identifier CTRI/2021/01/030827.
Association Between Pre-Transplant Oral Health and Post-Liver Transplant Complications
Authors: Olander Annika Emilia , Helenius-Hietala Jaana , Nordin Arno , Savikko Johanna , Ruokonen Hellevi , Åberg Fredrik
Published: September 2023

Oral disease is linked with systemic inflammation and various systemic conditions, including chronic liver disease. Liver transplantation (LT) candidates often need dental infection focus eradication, and after LT, there is high risk of many inflammation-related complications. We studied whether pre-LT dental status is associated with the occurrence of post-LT complications. This study included 225 adult LT recipients whose teeth were examined and treated before LT, and 40 adult LT recipients who did not have pre-LT dental data available. Data on post-LT complications were collected from the national liver transplant registry and followed up until the end of July 2020. Worse pre-LT dental status was associated with a higher risk of acute rejection post-LT compared to patients with good dental status. Worse dental status was also associated with higher 1-year-post-LT ALT levels and lower albumin levels. In conclusion, poor pre-LT oral health seems to associate with an increased risk of post-LT acute rejection and with elevated ALT levels and decreased albumin levels, suggesting an effect on post-LT liver health. Therefore, prevention and treatment of oral and dental diseases should be promoted early in the course of liver disease.
Development of a Novel Apparatus to Determine Multiaxial Tensile Failure Criteria of Bridge Repair Materials
Authors: Looney Trevor , Volz Jeffery
Published: September 2023

Aging infrastructure is increasingly costing taxpayers due to increased repair and replacement costs. Ultra-high performance concrete (UHPC) has recently been recognized as a viable material for both the repair of concrete and steel infrastructure as well as a replacement material for new structures due to its enhanced mechanical and durability properties. Such uses require a much better understanding of the multiaxial tensile properties of UHPC to utilize the material more efficiently. This study focused on developing a novel apparatus capable of subjecting specimens to tensile forces in each of the three principal directions simultaneously. Such an apparatus could collect data for a portion of the failure surface that currently only has a small dataset to establish trends. The “Looney Bin” was designed to test 50-mm cube specimens in triaxial tension, biaxial tension, tension-compression, and tension-tension-compression stress states. Once the apparatus and fixtures were designed and fabricated, trial tests were conducted on a non-proprietary UHPC without steel fibers to establish a test method for each of the stress states evaluated. Data were then collected for different stress states using the established procedures and plotted against previously published failure models for UHPC to verify that the collected data were reasonable.
Piling Data-Driven Framework for Optimized Pile Structures Based on Minimizing the Expected Total Cost
Authors: Suzuki Naoki , Nagai Kohei
Published: September 2023

The use of data in the construction industry is growing rapidly. However, projects that do not have multiple stages, such as pile foundation and cantilever wall construction, are difficult to reinforce based on the data of observation. It cannot be said that the design–build construction process is optimized by piling data and active learning. In this paper, a new data-driven framework is proposed so that it can be used even for construction under single-stage conditions. The proposed method adopts a lower safety factor (SF) in the preliminary design than that in the conventional methods, and checks the performance after the building using piling data. Countermeasures are conducted to satisfy the target reliability, if necessary. Focusing on the expected total cost, the parametric studies reveal that the proposed method can reduce the expected total cost under specific conditions, such as lower countermeasure cost, higher failure cost, and higher relative costs of safety measures. Furthermore, our method exhibits robustness, as even with low initial safety factors, the expected total cost does not become excessively larger compared to the conventional methods. The findings highlight the potential benefits of piling data for optimizing construction projects under single-stage conditions.
Tolerance and Oncological Outcomes of In-Field Reirradiation for Locally Recurrent Breast Cancer: A Long-Term Single-Center Experience
Authors: Baude Jérémy , Dendale Rémi , Cao Kim , Fourquet Alain , Kirova Youlia
Published: September 2023

Background: The management of cancer relapse in previously irradiated tissues is a challenging therapeutic issue. The aim of this work was to report our experience with breast reirradiation for locoregionally recurrent breast cancer. Methods: All patients who underwent breast or chest wall in-field reirradiation at the Institut Curie, Paris, France, between 2003 and 2019, were identified. Efficacy outcomes and physician-reported toxicities were retrospectively assessed. Results: A total of 21,372 patients underwent breast irradiation in our institution. Of these, 28 received a second course of radiotherapy to the homolateral breast/chest wall. A total of 18 (64%) patients were treated with a curative intent, and 10 (36%) were treated for palliative purposes. Only one acute and one late grade 3 adverse events were reported. One patient with major cardiovascular risk factors died of myocardial infarction 13 months after left breast reirradiation. The 2-year LRFS, OS, DSS, PFS and MFS were 59%, 79%, 82%, 46% and 75%, respectively, in the whole cohort. The 2-year LRFS (72% vs. 31%, p = 0.02), OS (94% vs. 50%, p < 0.01), DSS (94% vs. 56%, p < 0.01) and PFS (61% vs. 20%, p = 0.02) differed significantly between patients treated with curative or palliative intent but not the MFS (78% vs. 69%, p = 0.77). Among the patients, eight (29%) remained relapse-free 5 years after reirradiation. Conclusion: Breast/chest wall reirradiation appears to be feasible with good disease control, especially in patients treated with a curative intent, and presents acceptable toxicity rates.
Personalized Breast Cancer Screening: A Risk Prediction Model Based on Women Attending BreastScreen Norway
Authors: Louro Javier , Román Marta , Moshina Nataliia , Olstad Camilla F. , Larsen Marthe , Sagstad Silje , Castells Xavier , Hofvind Solveig
Published: September 2023

Background: We aimed to develop and validate a model predicting breast cancer risk for women targeted by breast cancer screening. Method: This retrospective cohort study included 57,411 women screened at least once in BreastScreen Norway during the period from 2007 to 2019. The prediction model included information about age, mammographic density, family history of breast cancer, body mass index, age at menarche, alcohol consumption, exercise, pregnancy, hormone replacement therapy, and benign breast disease. We calculated a 4-year absolute breast cancer risk estimates for women and in risk groups by quartiles. The Bootstrap resampling method was used for internal validation of the model (E/O ratio). The area under the curve (AUC) was estimated with a 95% confidence interval (CI). Results: The 4-year predicted risk of breast cancer ranged from 0.22–7.33%, while 95% of the population had a risk of 0.55–2.31%. The thresholds for the quartiles of the risk groups, with 25% of the population in each group, were 0.82%, 1.10%, and 1.47%. Overall, the model slightly overestimated the risk with an E/O ratio of 1.10 (95% CI: 1.09–1.11) and the AUC was 62.6% (95% CI: 60.5–65.0%). Conclusions: This 4-year risk prediction model showed differences in the risk of breast cancer, supporting personalized screening for breast cancer in women aged 50–69 years.
Artificial Intelligence in Digital Pathology for Bladder Cancer: Hype or Hope? A Systematic Review
Authors: Khoraminia Farbod , Fuster Saul , Kanwal Neel , Olislagers Mitchell , Engan Kjersti , van Leenders Geert J. L. H. , Stubbs Andrew P. , Akram Farhan , Zuiverloon Tahlita C. M.
Published: September 2023

Bladder cancer (BC) diagnosis and prediction of prognosis are hindered by subjective pathological evaluation, which may cause misdiagnosis and under-/over-treatment. Computational pathology (CPATH) can identify clinical outcome predictors, offering an objective approach to improve prognosis. However, a systematic review of CPATH in BC literature is lacking. Therefore, we present a comprehensive overview of studies that used CPATH in BC, analyzing 33 out of 2285 identified studies. Most studies analyzed regions of interest to distinguish normal versus tumor tissue and identify tumor grade/stage and tissue types (e.g., urothelium, stroma, and muscle). The cell’s nuclear area, shape irregularity, and roundness were the most promising markers to predict recurrence and survival based on selected regions of interest, with >80% accuracy. CPATH identified molecular subtypes by detecting features, e.g., papillary structures, hyperchromatic, and pleomorphic nuclei. Combining clinicopathological and image-derived features improved recurrence and survival prediction. However, due to the lack of outcome interpretability and independent test datasets, robustness and clinical applicability could not be ensured. The current literature demonstrates that CPATH holds the potential to improve BC diagnosis and prediction of prognosis. However, more robust, interpretable, accurate models and larger datasets—representative of clinical scenarios—are needed to address artificial intelligence’s reliability, robustness, and black box challenge.
Novel Advances in Treatment of Meningiomas: Prognostic and Therapeutic Implications
Authors: Caruso Gerardo , Ferrarotto Rosamaria , Curcio Antonello , Metro Luisa , Pasqualetti Francesco , Gaviani Paola , Barresi Valeria , Angileri Filippo Flavio , Caffo Maria
Published: September 2023

Meningiomas are the most frequent histotypes of tumors of the central nervous system. Their incidence is approximately 35% of all primary brain tumors. Although they have the status of benign lesions, meningiomas are often associated with a decreased quality of life due to focal neurological deficits that may be related. The optimal treatment is total resection. Histological grading is the most important prognostic factor. Recently, molecular alterations have been identified that are specifically related to particular phenotypes and, probably, are also responsible for grading, site, and prognostic trend. Meningiomas recur in 10–25% of cases. In these cases, and in patients with atypical or anaplastic meningiomas, the methods of approach are relatively insufficient. To date, data on the molecular biology, genetics, and epigenetics of meningiomas are insufficient. To achieve an optimal treatment strategy, it is necessary to identify the mechanisms that regulate tumor formation and progression. Combination therapies affecting multiple molecular targets are currently opening up and have significant promise as adjuvant therapeutic options. We review the most recent literature to identify studies investigating recent therapeutic treatments recently used for meningiomas.
Using Virtual Reality to Support Retrieval Practice in Blended Learning: An Interdisciplinary Professional Development Collaboration between Novice and Expert Teachers
Authors: Cowan Pamela , Farrell Rachel
Published: September 2023

This small-scale study comprised an evaluation of a teacher professional learning experience that involved the collaborative creation of resources using immersive virtual reality (VR) as a retrieval practice tool, specifically focusing on the open access aspects of the SchooVR platform. SchooVR offers teachers and students tools to enhance teaching and learning by providing a range of virtual field trips and the ability to create customised virtual tours aligned with curriculum requirements. By leveraging the immersive 360° learning environment, learners can interact with content in meaningful ways, fostering engagement and deepening understanding. This study draws on the experiences of a group of postgraduate teacher education students and co-operating teachers in Ireland and Northern Ireland who collaborated on the creation of a number of immersive learning experiences across a range of subjects during a professional learning event. The research showcases how immersive realities, such as VR, can be integrated effectively into blended learning spaces to create resources that facilitate retrieval practice and self-paced study, thereby supporting the learning process. By embedding VR experiences into the curriculum, students are given opportunities for independent practice, review, and personalised learning tasks, all of which contribute to the consolidation of knowledge and the development of metacognitive skills. The findings suggest that SchooVR and similar immersive technologies have the potential to enhance educational experiences and promote effective learning outcomes across a variety of subject areas.
A CFD Modelling Approach of Fuel Spray under Initial Non-Reactive Conditions in an Optical Engine
Authors: Corral-Gómez Lis , Martos Francisco J. , Fernández-Yáñez Pablo , Armas Octavio
Published: September 2023

A better understanding of why and how pollutant emissions from compression ignition engines are produced is one of the strategies to reduce them, and to achieve this it is important to understand what happens in the fuel injection inside the combustion chamber and in the combustion process. Experimentally, it is difficult to analyse the fuel spray right at the initial moments when it enters the combustion chamber due to its high velocity. These initial moments of the fuel spray affect its complete development and, consequently, the combustion process inside the chamber. This fact has motivated the approach of this work, in which a parametric study of the spray penetration as a function of variables that can be measured has been proposed. The purpose of this model is to understand which variables of the injection system significantly affect the spray penetration in the initial instants and how they affect it. This study was carried out using diesel and serves as a reference framework for similar studies using pure or blended sustainable advanced fuels. A computational fluid dynamics (CFD) model that determines the spray penetration at initial instants under different injection pressures and nozzle hole diameters is presented in this work. To tune the model, experiments were carried out on an optical engine. The modelled and experimental results exceed 94.8% agreement in all cases studied.
Combustion Instability and Ash Agglomeration in Wood Pellets Boiler
Authors: Fraga Lelis , Ferreira Eduardo , Ribeiro Pedro , Castro Carlos , Martins Jorge , Teixeira José C.
Published: September 2023

The combustion instability and ash agglomeration in a wood pellet boiler were investigated in this study. The tests were conducted using the Taguchi method of orthogonal array L27(133). Several parameters are applied, including grate area (GA), primary to secondary air split ratio (SR), excess air (EA), and fuel power (P). Pine wood pellets were used, and the boiler’s nominal load was 20 kW. The results show that instability during combustion occurs since the fuel bed rises as the accumulation of the unburned wood pellets on the grate causes a slow combustion rate and pressure drop, which creates noise and disturbances. A good combination of the parameters applied to TN9 and TN20 can be useful in obtaining stable combustion. In addition, the ash agglomerations were influenced by the duration of the combustion and the temperature of the fuel bed. The largest size of the ash agglomeration was referred to as test number-TN26 (P: 16 kW, EA: 110%, SR: 30/70, and GA: 115 mm × 75 mm), which is 59 mm, and the duration time is 14,400 s (≈4 h).
Flavour Characteristics of Fermented Meat Products in China: A Review
Authors: Hao Mai , Wang Wei , Zhang Jiamin , Chen Lin
Published: September 2023

Fermentation of meat products refers to a series of physical, biological or chemical changes in raw meat that occurs under the actions of enzymes or via microbial fermentation and results in the formation of meat products with special flavours, colours and textures that have a long history in China. These products have a unique fermented flavour, bright colour and longer shelf life than ordinary meat products, and some have proteins that are more easily absorbed by the body due to the fermentation of beneficial bacteria. Flavour development in meat products is a dynamic process. During the processing and storage of fermented meat products, the breakdown of proteins and fats is accelerated due to the addition of different fermenting agents. Moreover, the physicochemical reactions that occur within the meat products and the actions of microorganisms during the fermentation process result in the production of flavour compounds, which will determine the final flavour characteristics of the fermented meat product. This paper reviews the flavour characteristics of Chinese dry-cured hams, sausages, bacon, cured fish and sour meat and analyses the flavour substance composition of various products. Due to the differences in the raw materials, processes, auxiliary materials and fermentation processes of various types of fermented meat products in China (ham, sausage, bacon, etc.), the flavour substances contained in the various types of fermented meat products in China are different from each other. However, most fermented meat products in China are cured and fermented, and therefore, they share similarities in terms of their flavour substance composition. The flavour substances in fermented meat products mainly include alcohols, ketones, aldehydes, acids, phenols and aromatic hydrocarbons. The study of such flavour characteristics is of great significance in fermented meat product quality, and provides certain theoretical references for the study of domestic fermented meat products.
Binding of YY1/CREB to an Enhancer Region Triggers Claudin 6 Expression in H. pylori LPS-Stimulated AGS Cells
Authors: Romero-Estrada Jorge H. , Montaño Luis F. , Rendón-Huerta Erika P.
Published: September 2023

Aberrant expression of the tight junction protein claudin 6 (CLDN6) is a hallmark of gastric cancer progression. Its expression is regulated by the cAMP response element-binding protein (CREB). In gastric cancer induced by Helicobacter pylori (H. pylori) there is no information regarding what transcription factors induce/upregulate the expression of CLDN6. We aimed to identify whether CREB and Yin Yang1 (YY1) regulate the expression of CLDN6 and the site where they bind to the promoter sequence. Bioinformatics analysis, H. pylori lipopolysaccharide (LPS), YY1 and CREB silencing, Western blot, luciferase assays, and chromatin immunoprecipitation experiments were performed using the stomach gastric adenocarcinoma cell line AGS. A gen reporter assay suggested that the initial 2000 bp contains the regulatory sequence associated with CLDN6 transcription; the luciferase assay demonstrated three different regions with transcriptional activity, but the −901 to −1421 bp region displayed the maximal transcriptional activity in response to LPS. Fragment 1279–1421 showed CREB and, surprisingly, YY1 occupancy. Sequential Chromatin Immunoprecipitation (ChIP) experiments confirmed that YY1 and CREB interact in the 1279–1421 region. Our results suggest that CLDN6 expression is regulated by the binding of YY1 and CREB in the 901–1421 enhancer, in which a non-described interaction of YY1 with CREB was established in the 1279–1421 region.
Pitaya Nutrition, Biology, and Biotechnology: A Review
Authors: Shah Kamran , Chen Jiayi , Chen Jiaxuan , Qin Yonghua
Published: September 2023

Pitaya (Hylocereus spp.) is a member of the cactus family that is native to Central and South America but is now cultivated throughout the sub-tropical and tropical regions of the world. It is of great importance due to its nutritional, ornamental, coloring, medicinal, industrial, and high consumption values. In order to effectively utilize and develop the available genetic resources, it is necessary to appreciate and understand studies pertaining to the usage, origin, nutrition, diversity, evaluation, characterization, conservation, taxonomy, and systematics of the genus Hylocereus. Additionally, to gain a basic understanding of the biology of the plant, this review has also discussed how biotechnological tools, such as cell and tissue culture, micropropagation (i.e., somatic embryogenesis, organogenesis, somaclonal variation, mutagenesis, androgenesis, gynogenesis, and altered ploidy), virus-induced gene silencing, and molecular marker technology, have been used to enhance pitaya germplasm.
The Incidence Rate, Microbiological Etiology, and Results of Treatments of Prosthetic Joint Infection following Total Knee Arthroplasty
Authors: Yoon Han-Kook , Yoo Ju-Hyung , Oh Hyun-Cheol , Ha Joong-Won , Park Sang-Hoon
Published: September 2023

Periprosthetic joint infection (PJI) remains among the most challenging and costly complications. PJI rates vary from 0.39% to 3.9% after total knee arthroplasty (TKA). This study aimed to identify the causative microorganisms involved and to report our experience of subsequent treatment of PJI following over 7000 TKAs performed over 19 years. A retrospective study was conducted on 4547 patients (7019 cases) from March 2000 to September 2019. The incidence rate of PJI was 0.5%. Gram-positive bacteria accounted for 88.8% (n = 16) of the 18 cases, and S. aureus was the most commonly isolated pathogen (n = 7, 38.8%). There were six cases of MSSA and one case of MRSA. Streptococcus species (n = 7, 38.8%) also showed the same pattern. The CoNS species (n = 2, 11.1%) and Gram-negative bacteria (n = 1, 5.5%) were also reported. Candida species were isolated from 1 patient (5.5%). Successful I&D and implant retention (DAIR procedures) was achieved at the final follow-up in 19 patients (82.6%). The incidence of causative microorganisms was different for each PJI onset type. The overall infection rate of PJI was less than 1%. Although the success rate of DAIR procedures is lower than the two-stage exchange arthroplasty in this study, it is possible to achieve acceptable success rates if DAIR procedures are carefully selected considering the virulence of the microorganism, duration since symptom onset, and early-onset infection.
Influence of Implant Macro-Design, -Length, and -Diameter on Primary Implant Stability Depending on Different Bone Qualities Using Standard Drilling Protocols—An In Vitro Analysis
Authors: Stoilov Milan , Shafaghi Ramin , Stark Helmut , Marder Michael , Kraus Dominik , Enkling Norbert
Published: September 2023

(1) Background: Primary implant stability is vital for successful implant therapy. This study explores the influence of implant shape, length, and diameter on primary stability in different bone qualities. (2) Methods: Three implant systems (two parallel-walled and one tapered) with various lengths and diameters were inserted into polyurethane foam blocks of different densities (35, 25, 15, and 10 PCF) using standard drilling protocols. Primary stability was assessed through insertion torque (IT) and resonance frequency analysis (RFA). Optimal ranges were defined for IT (25 to 50 Ncm) and RFA (ISQ 60 to 80). A comparison of implant groups was conducted to determine adherence to the optimal ranges. (3) Results: Implant macro-design, -length, and -diameter and bone block density significantly influenced IT and RFA. Optimal IT was observed in 8/40 and 9/40 groups for the parallel-walled implants, while the tapered implant achieved optimal IT in 13/40 groups (within a 25–50 Ncm range). Implant diameter strongly impacted primary stability, with sufficient stability achieved in only one-third of cases despite the tapered implant’s superiority. (4) Conclusions: The findings highlight the need to adapt the drilling protocol based on diverse bone qualities in clinical practice. Further investigations should explore the impact of these adapted protocols on implant outcomes.
Exploring the Influence of Cognitive and Ecological Dynamics Approaches on Countermovement Jumping Enhancement: A Comparative Training Study
Authors: Di Domenico Felice , D’Isanto Tiziana , Esposito Giovanni , Aliberti Sara , Raiola Gaetano
Published: September 2023

Countermovement jumping (CMJ) and free-arm countermovement jumping (CMJFA) express the explosive-elastic force of the lower limbs. Strategies to enhance performance in both types of jumping can be categorized into cognitive and ecological-dynamic approaches. However, the effectiveness of these approaches in improving CMJ and CMJFA remains incompletely understood. This study aims to investigate the impact of training protocols based on the two approaches to improving CMJ. Thirty-six subjects with an average age of 26 years were selected and divided into two groups: the ecological-dynamic group (EDG) and the cognitive group (CG). For 12 weeks, both groups followed separate protocols of three weekly one-hour sessions. EDG group followed a protocol focused on circle time. The CG group followed an instructor-led training protocol. Incoming and outgoing flight heights were measured. Pre and post-intervention differences within and between groups were assessed using t-tests for dependent and independent samples, respectively (p ≤ 0.05). CG demonstrated a 12.2% increase in CMJ and a 7.8% improvement in CMJFA, while EDG showed a 10.2% increase in CMJ and 19.5% progress in CMJFA. No statistically significant differences (p > 0.05) were observed between the groups in the improvement of CMJ; statistically significant differences (p < 0.05) were found in the improvement of CMJFA in favor of EDG.
Output Feedback Stabilization of Doubly Fed Induction Generator Wind Turbines under Event-Triggered Implementations
Authors: Abdelrahim Mahmoud , Almakhles Dhafer
Published: September 2023

The robust stabilization of doubly fed induction generators in wind turbines against external disturbances is considered in this study. It is assumed that the angular speeds of wind turbines can only be measured and sent to the controller in a discrete-time fashion over a network. To generate the sampling times, three different triggering schemes were developed: time-triggering, static event-triggering, and dynamic event-triggering mechanisms; moreover, performance comparisons were conducted between such approaches. The design methodology is based on emulation, such that the plant is first stabilized in continuous-time where a robust feedback law is constructed based on the linear quadratic Gaussian regulator (LQG) approach. Then, the impact of the network is taken into account, and an event-triggering mechanism is built so that closed-loop stability is maintained and the Zeno phenomenon is avoided by using temporal regularization. The necessary stability constraints are framed as a linear matrix inequality, and the whole system is modeled as a hybrid dynamical system. A numerical simulation is used to demonstrate the effectiveness of the control strategy. The results show that the event-triggering mechanisms achieve a significant reduction of around 50% in transmissions compared to periodic sampling. Moreover, numerical comparisons with existing approaches show that the proposed approach provides better performance in terms of the stability guarantee and number of transmissions.
The Efficiency of Sclerotherapy for the Management of Endometrioma: A Systematic Review and Meta-Analysis of Clinical and Fertility Outcomes
Authors: Ronsini Carlo , Iavarone Irene , Braca Eleonora , Vastarella Maria Giovanna , De Franciscis Pasquale , Torella Marco
Published: September 2023

Background and Objectives: The most common sites of implantation of endometriotic tissue are the ovaries. Endometriomas are present in most cases of endometriosis (up to 45%). Although laparoscopic cystectomy is the standard of care in endometrioma, new strategies have been set up to minimize iatrogenic injuries to ovarian tissue. Sclerotherapy consists of injecting alcohol into the endometrioma to denature the amino acidic components of its pseudocapsule. The aim of this systematic review and meta-analysis is to compare clinical and pregnancy outcomes in surgery and sclerotherapy. Materials and Methods: Following the recommendations in the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement, we systematically searched PubMed, EMBASE, Scopus, Google Scholar, Clinical-trials.gov, and the Cochrane Central Register of Controlled Trials databases in January 2023, adopting the string “Endometriosis and sclerotherapy”. We made no limitations on the country and year of publication. We included the studies containing Success Rate (SR), Recurrence Rate (RR), Pregnancy Rate (PR) before and after the procedure. We used comparative studies for meta-analysis. Results: A total of 29 studies fulfilled inclusion criteria, 7 retrospective observational studies and 22 prospective studies. Eight comparative studies were enrolled in meta-analysis. Patients were analyzed concerning the number of recurrences and pregnancies in surgery, and compared with sclerotherapy. Four studies showed SR > 80.0%, and only two had SR < 80.0%, of which one consisted of tetracycline instillation. Only 1 study had 100% PR, the other 14 reported PR > 30.0%, whereas six had PR < 30.0%, of which one showed 0.0% PR with ethanol injection at two-thirds of the cyst fluid volume. Meta-analysis highlighted a non-significant lower incidence of recurrence in the surgery group compared to the sclerotherapy group (p = 0.87). In parallel, the surgery group showed a non-significant better PR than the sclerotherapy group (p = 0.08). Conclusions: Despite sclerotherapy having a minor incidence of postoperative complications compared to surgery, the latter is associated with a lower RR and better PR. However, those data assert the importance of a targeted therapy according to preoperative conditions and reproductive potential.
Hexakis-2-(β-carboxyethenylphenoxy)cyclotriphosphazene: Synthesis, Properties, Modeling Structure
Authors: Yudaev Pavel , Konstantinova Anastasia , Volkov Vladimir , Chistyakov Evgeniy
Published: September 2023

Condensation of hexakis-2-(formylphenoxy)cyclotriphosphazene with malonic acid yielded hexakis-2-(β-carboxyethenylphenoxy)cyclotriphosphazene (2-CEPP), whose structure was confirmed by 31P, 1H, 13C NMR spectroscopy and MALDI-TOF mass spectrometry. A quantum-chemical calculation for the 2-CEPP molecule using the ab initio methods in the 6-311G** basis set and the DFT-PBE0/6-311g** method was performed with geometry optimization of all parameters by the standard gradient method. The acid strength of 2-CEPP was theoretically estimated. Using the small-angle X-ray scattering method, it was found that 2-CEPP is an amorphous substance, which, when heated, can transform into a crystalline state. However, when heated at 370 °C, 2-CEPP undergoes decarboxylation and polymerization to form an insoluble heat-resistant product. The occurrence of decarboxylation and polymerization reactions in the formed styrene fragments was confirmed by thermal (differential-scanning calorimetry) and spectral (solid-state 13C NMR spectroscopy) analysis.
Rhodamine-Anchored Polyacrylamide Hydrogel for Fluorescent Naked-Eye Sensing of Fe3+
Authors: Jiang Dandan , Zheng Minghao , Ma Xiaofan , Zhang Yingzhen , Jiang Shaohua , Li Juanhua , Zhang Chunmei , Liu Kunming , Li Liqing
Published: September 2023

A fluorescent and colorimetric poly (acrylamide)-based copolymer probe P(AAm-co-RBNCH) has been designed via free radical polymerization of a commercial acrylamide monomer with a rhodamine-functionalized monomer RBNCH. Metal ion selectivity of RBNCH was investigated by fluorescence and colorimetric spectrophotometry. Upon addition of Fe3+, a visual color change from colorless to red and a large fluorescence enhancement were observed for the ring-opening of the rhodamine spirolactam mechanism. The monomer gives a sensitive method for quantitatively detecting Fe3+ in the linear range of 100–200 μM, with a limit of detection as low as 27 nM and exhibiting high selectivity for Fe3+ over 12 other metal ions. The hydrogel sensor was characterized by FTIR, and the effects of RBNCH amount on gel content and swelling properties were explored. According to the recipe of 1.0 mol% RBNCH to the total monomers, the fabricated hydrogel sensor displayed a good swelling property and reversibility performance and has potential for application in the imaging of Fe3+ level in industrial wastewater.
Simultaneous Determination of 54 Pesticides in Proso Millet Using QuEChERS with Liquid Chromatography-Tandem Mass Spectrometry (LC–MS/MS)
Authors: Ding Chao , Ren Pengcheng , Qi Yanli , Yang Yanmei , Qin Shu
Published: September 2023

To assess the potential risks posed to the environment and human health, analyzing pesticide residues in proso millet is important. This paper aimed to develop a modified QuEChERS method with liquid chromatography-tandem mass spectrometry (LC–MS/MS) for the analysis of 54 pesticide residues in proso millet. Parameters including the mobile phase of the instrument, the acidity of the extraction solvent, and the type of absorbents were optimized to provide satisfactory performance. The method was validated concerning linearity, limit of quantification (LOQ), matrix effect, accuracy, and precision. In detail, the linearity of the matrix-matched calibration curve was acceptable with correlation coefficients (R2) higher than 0.99. The mean recovery was in the range of 86% to 114% with relative standard deviations (RSDs) ≤ 20% (n = 5). The LOQ was determined to be 0.25–10 μg/kg. The developed method was feasible for the determination of multiple pesticide residues in proso millet.
Wetting Properties of Simulated and Commercial Contaminants on High Transmittance Superhydrophobic Coating
Authors: Ferrari Michele , Cirisano Francesca
Published: September 2023

The large and necessary diffusion of huge solar plants in extra urban areas implies the adoption of maintenance strategies especially where human intervention would require high costs and logistic problems. Animal dejections like bird droppings and agricultural sprays are environmental agents able to significantly decrease light absorption and, in some cases, cause serious damage to the electric conversion systems in a photovoltaic panel. In this work, the performance of a superhydrophobic (SH) coating in terms of durable self-cleaning properties and transparency has been studied in the presence of commercial and simulated contaminants on glass reference and solar panel surfaces. Wettability studies have been carried out both in static and dynamic conditions in order to compare the compositional effect of commercial liquids used as fertilizers or pesticides and molecules like pancreatin as model substances simulating bird droppings. From these studies, it can be observed that the superhydrophobic coating, independently from the surface where it is applied, is able to repel water and substances used such as fertilizers or pesticides and substances simulating bird droppings, maintaining its properties and transparency. This kind of approach can provide information to design suitable spray formulations without the above-mentioned drawbacks to be used in natural environment areas and agrosolar plants.
Application of Bioelectrical Impedance Analysis in Nutritional Management of Patients with Chronic Kidney Disease
Authors: Guo Yanchao , Zhang Meng , Ye Ting , Wang Zhixiang , Yao Ying
Published: September 2023

Body composition measurement plays an important role in the nutritional diagnosis and treatment of diseases. In the past 30 years, the detection of body composition based on bioelectrical impedance analysis (BIA) has been widely used and explored in a variety of diseases. With the development of technology, bioelectrical impedance analysis has gradually developed from single-frequency BIA (SF-BIA) to multi-frequency BIA (multi-frequency BIA, MF-BIA) and over a range of frequencies (bioimpedance spectroscopy, BIS). As the clinical significance of nutrition management in chronic kidney disease has gradually become prominent, body composition measurement by BIA has been favored by nephrologists and nutritionists. In the past 20 years, there have been many studies on the application of BIA in patients with CKD. This review describes and summarizes the latest research results of BIA in nutritional management of patients with CKD including pre-dialysis, hemodialysis, peritoneal dialysis and kidney transplantation, in order to provide reference for the application and research of BIA in nutritional management of chronic kidney disease in the future.
Evaluation of Self-Degradation and Plugging Performance of Temperature-Controlled Degradable Polymer Temporary Plugging Agent
Authors: Xu Hualei , Zhang Liangjun , Wang Jie , Jiang Houshun
Published: September 2023

Temporary plugging diversion fracturing (TPDF) technology has been widely used in various oil fields for repeated reconstruction of high-water-cut old oil wells and horizontal well reservoir reconstruction. Previous studies have carried out in-depth study on the pressure-bearing law and placement morphology of different types of temporary plugging agents (TPAs) in fractures, but there are relatively few studies on TPA accumulation body permeability. To solve this problem, an experimental device for evaluating the TPA performance with adjustable fracture pores is proposed in this paper. Based on the test of fracturing fluid breaking time and residue content, the low damage of fracturing fluid to the reservoir is determined. The TPA degradation performance test determines whether the TPA causes damage to the hydraulic fracture after the temporary plugging fracturing. Finally, by testing the TPA pressure-bearing capacity and the temporary plugging aggregation body permeability, the plugging performance and the aggregation body permeability are determined. The results show the following: (1) Guar gum fracturing fluid shows good gel-breaking performance under the action of breaking agent, and the recommended concentration of breaking agent is 300 ppm. At 90~120 °C, the degradation rate of the three types of TPAs can reach more than 65%, and it can be effectively carried into the wellbore during the fracturing fluid flowback stage to achieve the effect of removing the TPA in the fracture. (2) The results of the pressure-bearing performance of the TPA show that the two kinds of TPAs can quickly achieve the plugging effect after plugging start: the effect of ZD-2 (poly lactic-co-glycolic acid (PLGA)) particle-and-powder combined TPA on forming an effective temporary plugging accumulation body in fractures is better than that of ZD-1 (PLGA) pure powder. There are large pores between the particles, and the fracturing fluid can still flow through the pores, so the ZD-3 (a mixture of lactide and PLGA) granular temporary plugging agent cannot form an effective plugging. (3) The law of length of the temporary plugging accumulation body shows that the ZD-2 combined TPA has stronger plugging ability for medium-aperture simulated fracture pores, while the ZD-1 powder TPA has stronger plugging ability for small aperture simulated fracture pores, and the ZD-3 granular TPA should be avoided alone as far as possible. This study further enriches and improves the understanding of the mechanism of temporary plugging diverting fracturing fluid.
Hydrogelation of Regenerated Silk Fibroin via Gamma Irradiation
Authors: Thongnuek Peerapat , Kanokpanont Sorada , Uttayarat Pimpon , Damrongsakkul Siriporn
Published: September 2023

Gamma irradiation, which is one of the more conventional sterilization methods, was used to induce the hydrogelation of silk fibroin in this study. The physical and chemical characteristics of the irradiation-induced silk fibroin hydrogels were investigated. Silk fibroin solution with a concentration greater than 1 wt% formed hydrogel when irradiated by gamma rays at a dose of 25 or 50 kGy. The hydrogel induced by 50 kGy of radiation was more thermally stable at 80 °C than those induced by 25 kGy of radiation. When compared to the spontaneously formed hydrogels, the irradiated hydrogels contained a greater fraction of random coils and a lower fraction of β-sheets. This finding implies that gelation via gamma irradiation occurs via other processes, in addition to crystalline β–sheet formation, which is a well-established mechanism. Our observation suggests that crosslinking and chain scission via gamma irradiation could occur in parallel with the β–sheet formation. The irradiation-induced hydrogels were obtained when the solution concentration was adequate to support the radiation crosslinking of the silk fibroin chains. This work has, therefore, demonstrated that gamma irradiation can be employed as an alternative method to produce chemical-free, random coil-rich, and sterilized silk fibroin hydrogels for biomedical applications.
Preparation and Product Characterization of Microwaveable Food Using Lentinus edodes Protein through 3D Printing
Authors: Li Na , Li Hongbo , Liu Zhenbin , Lv Shuang , Xie Suya , Shi Chunyang , Wu Yue
Published: September 2023

The Lentinus edodes protein (LP) is a high-quality protein known for its well-balanced amino acid composition. In this study, we developed three-dimensional (3D)-printed microwaveable food using a combination of LP and potato flour, and optimized the formulation to achieve a ratio of LP: potato flour: xanthan gum: water = 2:8:1:23. The 3D-printed samples exhibited better shape, weight, and size compared to the molded samples after microwave treatment, with the most favorable microwave effect observed at a 90% filling ratio. The LP content affected the viscosity and retrogradation value of the LP–potato starch mixture. Microwave duration affected the surface hardness, interior softness, and moisture content of the product. The highest overall score of 8.295 points was obtained with a microwave processing duration of 2 min. This study lays a foundation for the development of LP-based 3D-printed food.