bluuebunny/crossref_metadata_2025 huggingface dataset:
Significance of upfront cytoreductive nephrectomy stratified by IMDC risk for metastatic renal cell carcinoma in targeted therapy era – a multi-institutional retrospective study
Authors: Kato Renpei , Naito Sei , Numakura Kazuyuki , Hatakeyama Shingo , Koguchi Tomoyuki , Kojima Takahiro , Kawasaki Yoshihide , Kandori Shuya , Kawamura Sadafumi , Arai Yoichi , Ito Akihiro , Nishiyama Hiroyuki , Kojima Yoshiyuki , Ohyama Chikara , Habuchi Tomonori , Tsuchiya Norihiko , Obara Wataru
Published: January 2022

Background

This retrospective multicenter study aimed to evaluate the survival benefit of upfront cytoreductive nephrectomy (CN) in metastatic renal cell carcinoma (RCC) patients stratified by International Metastatic RCC Database Consortium (IMDC) risk criteria.

Methods

We reviewed the medical records in the Michinoku Database between 2008 and 2019. Patients who received upfront CN, systemic therapy without CN (no CN) and CN after drug therapy (deferred CN) were analyzed. To exclude selection bias due to patient characteristics, baseline clinical data were adjusted by inverse probability of treatment weighting (IPTW). Overall survival (OS) was compared between upfront CN and non-upfront CN (no CN plus deferred CN). Associations between time-varying covariates including systemic therapies and OS stratified by IMDC risk criteria were analyzed by IPTW-adjusted Cox regression method.

Results

Of 259 patients who fulfilled the selection criteria, 107 were classified in upfront CN and 152 in non-upfront CN group. After IPTW-adjusted analysis, upfront CN showed survival benefit compared to non-upfront CN in patients with IMDC intermediate risk (median OS: 52.5 versus 31.3 months, p < 0.01) and in patients with IMDC poor risk (27.2 versus 11.4 months, p < 0.01). In IPTW-adjusted Cox regression analysis of time-varying covariates, upfront CN was independently associated with OS benefit in patients with IMDC intermediate risk (hazard ratio 0.52, 95% confidence interval 0.29–0.93, p = 0.03) and in patients with IMDC poor risk (0.26, 0.11–0.59, p < 0.01).

Conclusions

Upfront CN may confer survival benefit in RCC patients with IMDC intermediate and poor risk.
Tracing all patients who received insured dialysis treatment in Japan and the present situation of their number of deaths
Authors: Kubo Shinichiro , Noda Tatsuya , Myojin Tomoya , Nishioka Yuichi , Kanno Saho , Higashino Tsuneyuki , Nishimoto Masatoshi , Eriguchi Masahiro , Samejima Kenichi , Tsuruya Kazuhiko , Imamura Tomoaki
Published: January 2022

Background

The survival rate of chronic dialysis patients in Japan remains the highest worldwide, so there is value in presenting Japan’s situation internationally. We examined whether aggregate figures on dialysis patients in the National Database of Health Insurance Claims and Special Health Checkups of Japan (NDB), which contains data on insured procedures of approximately 100 million Japanese residents, complement corresponding figures in the Japanese Society for Dialysis Therapy Renal Data Registry (JRDR).

Methods

Subjects were patients with medical fee points for dialysis recorded in the NDB during 2014–2018. We analyzed annual numbers of dialysis cases, newly initiated dialysis cases– and deaths.

Results

Compared with the JRDR, the NDB had about 6–7% fewer dialysis cases but a similar number of newly initiated dialysis cases. In the NDB, the number of deaths was about 6–10% lower, and the number of hemodialysis cases was lower, while that of peritoneal dialysis cases was higher. The cumulative survival rate at dialysis initiation was approximately 6 percentage points lower in the NDB than in the JRDR, indicating that some patients die at dialysis initiation. Cumulative survival rate by age group was roughly the same between the NDB and JRDR in both sexes.

Conclusion

The use of the NDB enabled us to aggregate data of dialysis patients. With the definition of dialysis patients used in this study, analyses of concomitant medications, comorbidities, surgeries, and therapies will become possible, which will be useful in many future studies.
Applying machine learning to study fluid mechanics
Authors: Brunton Steven L.
Published: January 2022

This paper provides a short overview of how to use machine learning to build data-driven models in fluid mechanics. The process of machine learning is broken down into five stages: (1) formulating a problem to model, (2) collecting and curating training data to inform the model, (3) choosing an architecture with which to represent the model, (4) designing a loss function to assess the performance of the model, and (5) selecting and implementing an optimization algorithm to train the model. At each stage, we discuss how prior physical knowledge may be embedding into the process, with specific examples from the field of fluid mechanics.

Graphic abstract
Toward ‘seeing’ critically: a Bayesian analysis of the impacts of a critical pedagogy
Authors: Ng Stella L. , Crukley Jeff , Brydges Ryan , Boyd Victoria , Gavarkovs Adam , Kangasjarvi Emilia , Wright Sarah , Kulasegaram Kulamakan , Friesen Farah , Woods Nicole N.
Published: January 2022

Critical reflection supports enactment of the social roles of care, like collaboration and advocacy. We require evidence that links critical teaching approaches to future critically reflective practice. We thus asked: does a theory-informed approach to teaching critical reflection influence what learners talk about (i.e. topics of discussion) and how they talk (i.e. whether they talk in critically reflective ways) during subsequent learning experiences? Pre-clinical students (n = 75) were randomized into control and intervention conditions (8 groups each, of up to 5 interprofessional students). Participants completed an online Social Determinants of Health (SDoH) module, followed by either: a SDoH discussion (control) or critically reflective dialogue (intervention). Participants then experienced a common learning session (homecare curriculum and debrief) as outcome assessment, and another similar session one-week later. Blinded coders coded transcripts for what (topics) was said and how (critically reflective or not). We constructed Bayesian regression models for the probability of meaning units (unique utterances) being coded as particular what codes and as critically reflective or not (how). Groups exposed to the intervention were more likely, in a subsequent learning experience, to talk in a critically reflective manner (how) (0.096 [0.04, 0.15]) about similar content (no meaningful differences in what was said). This difference waned at one-week follow up. We showed experimentally that a particular critical pedagogical approach can make learners’ subsequent talk, ways of seeing, more critically reflective even when talking about similar topics. This study offers the field important new options for studying historically challenging-to-evaluate impacts and supports theoretical assertions about the potential of critical pedagogies.
Multiple weak supervision for short text classification
Authors: Chen Li-Ming , Xiu Bao-Xin , Ding Zhao-Yun
Published: January 2022

For short text classification, insufficient labeled data, data sparsity, and imbalanced classification have become three major challenges. For this, we proposed multiple weak supervision, which can label unlabeled data automatically. Different from prior work, the proposed method can generate probabilistic labels through conditional independent model. What’s more, experiments were conducted to verify the effectiveness of multiple weak supervision. According to experimental results on public dadasets, real datasets and synthetic datasets, unlabeled imbalanced short text classification problem can be solved effectively by multiple weak supervision. Notably, without reducingprecision,recall, andF1-scorecan be improved by adding distant supervision clustering, which can be used to meet different application needs.
Low-Cost Strategies to Improve Municipal Solid Waste Management in Developing Countries: Experimental Evidence from Nepal
Authors: Nepal Mani , Karki Nepal Apsara , Khadayat Madan S. , Rai Rajesh K. , Shyamsundar Priya , Somanathan E.
Published: January 2022

Many cities in developing countries lack adequate drainage and waste management infrastructure. Consequently, city residents face economic and health impacts from flooding and waterlogging, which are aggravated by solid waste infiltrating and blocking drains. City governments have recourse to two strategies to address these problems: a) ‘hard’ infrastructure-related interventions through investment in the expansion of drainage and waste transportation networks; and/or, b) ‘soft’, low-cost behavioural interventions that encourage city residents to change waste disposal practices. This research examines whether behavioural interventions, such as information and awareness raising alongside provision of inexpensive street waste bins, can improve waste management in the city. We undertook a cluster randomized controlled trial study in Bharatpur, Nepal, where one group of households was treated with a soft, low-cost intervention (information and street waste bins) while the control group of households did not receive the intervention. We econometrically compared baseline indicators – perceived neighbourhood cleanliness, household waste disposal methods, and at-source waste segregation – from a pre-intervention survey with data from two rounds of post-intervention surveys. Results from analysing household panel data indicate that the intervention increased neighbourhood cleanliness and motivated the treated households to dispose their waste properly through waste collectors. The intervention, however, did not increase household waste segregation at source, which is possibly because of municipal waste collectors mixing segregated and non-segregated waste during collection. At-source segregation, a pre-requisite for efficiently managing municipal solid waste, may improve if municipalities arrange to collect and manage degradable and non-degradable waste separately.
Construction of a prediction model for drug removal rate in hemodialysis based on chemical structures
Authors: Nishikiori Kousuke , Tanaka Kentaro , Uesawa Yoshihiro
Published: January 2022

In designing drug dosing for hemodialysis patients, the removal rate (RR) of the drug by hemodialysis is important. However, acquiring the RR is difficult, and there is a need for an estimation method that can be used in clinical settings. In this study, the RR predictive model was constructed using the RR of known drugs by quantitative structure–activity relationship (QSAR) analysis. Drugs were divided into a model construction drug set (75%) and a model validation drug set (25%). The RR was collected from 143 medicines. The objective variable (RR) and chemical structural characteristics (descriptors) of the drug (explanatory variable) were used to construct a prediction model using partial least squares (PLS) regression and artificial neural network (ANN) analyses. The determination coefficients in the PLS and ANN methods were 0.586 and 0.721 for the model validation drug set, respectively. QSAR analysis successfully constructed dialysis RR prediction models that were comparable or superior to those using pharmacokinetic parameters. Considering that the RR dataset contains potential errors, we believe that this study has achieved the most reliable RR prediction accuracy currently available. These predictive RR models can be achieved using only the chemical structure of the drug. This model is expected to be applied at the time of hemodialysis.

Graphic Abstract
Large-scale comparative transcriptomic analysis of temperature-responsive genes in Arabidopsis thaliana
Authors: Sriden Napaporn , Charoensawan Varodom
Published: January 2022

Key message

Comparative transcriptomic analysis provides broad and detailed understandings of transcriptional responses to a wide range of temperatures in different plant tissues, and unique regulatory functions of temperature-mediating transcription factors.

Climate change poses a great threat to plant diversity and food security. It is thus of necessity to understand the molecular mechanisms for perceiving and responding to adverse temperature changes, to develop the cultivars that are resilient to these environmental stresses. Making use of publicly available datasets, we gathered and re-analyzed 259 individual transcriptomic profiles from 139 unique experiments of Arabidopsis thaliana’s shoot, root, and seedling tissues, subjected to a wide variety of temperature conditions, ranging from freezing, cold, low and high ambient temperatures, to heat shock. Despite the underlying differences in the overall transcriptomic profiles between the plant tissues, we were able to identify distinct sets of genes whose transcription patterns were highly responsive to different types of temperature conditions, some were common among the tissues and some were tissue-specific. Interestingly, we observed that the known temperature-responsive genes such as the heat-shock factor (HSF) family, were up-regulated not only in response to high temperatures, but some of its members were also likely involved in the cold response. By integrating the DNA-binding specificity information of the key temperature transcription factor (TF) HSFA1a, PIF4, and CBFs, we elucidated their distinct DNA-binding patterns to the target genes that showed different transcriptional responses. Taken together, we have comprehensively characterized the transcription patterns of temperature-responsive genes and provided directly testable hypotheses on the regulatory roles of key temperature TFs on the expression dynamics of their target genes.
When Is an Interview an Inter View? The Historical and Recent Development of Methodologies Used to Investigate Children’s Astronomy Knowledge
Authors: Blown Eric J. , Bryce Tom G. K.
Published: January 2022

This paper provides a historical review of the interview research that has been used by science educators to investigate children’s basic astronomy knowledge. A wide range of strategies have been developed over the last 120 years or so as successive teams of researchers have endeavoured to overcome the methodological difficulties that have arisen. Hence, it looks critically at the techniques that have been developed to tackle the problems associated with interviews, questionnaires and tests used to research cognitive development and knowledge acquisition. We examine those methodologies which seem to yield surer indications of how young people (at different ages) understand everyday astronomical phenomena—the field often referred to aschildren’s cosmologies. Theoretical ideas from cognitive psychology, educational instruction and neuroscience are examined in depth and utilised to critique matters such as the importance of subject mastery and pedagogical content knowledge on the part of interviewers; the merits of multi-media techniques; the roles of open-ended vs. structured methods of interviewing; and the need always to recognise the dynamism of memory in interviewees. With illustrations and protocol excerpts drawn from recent studies, the paper points to what researchers might usefully tackle in the years ahead and the pitfalls to be avoided.
Influence of fat-free mass and resting metabolic rate on increased food reinforcement after exercise training
Authors: Pankey Christopher L. , Flack Kyle , Ufholz Kelsey , Johnson LuAnn , Roemmich James N.
Published: January 2022

Purpose

Models of appetite control have been largely based on negative feedback from gut and adipose signaling to central appetite centers. However, contemporary models posit that fat-free mass (FFM) or the energy demand of FFM [i.e., resting metabolic rate (RMR)] may play a primary role in the motivational drive for food intake (i.e., food reinforcement). The relative reinforcing value of food (RRVfood) is associated with energy intake (EI) and increases with an acute energy deficit. Chronic exercise-induced energy deficits lead to alterations in fat mass (FM), FFM, and RMR and provide an opportunity to test whether change in (∆) FM, ∆FFM, ∆usual EI, or ∆RMR are associated with ∆RRVfood.

Methods

Participants (n = 29, BMI = 25–35 kg/m2) engaged in aerobic exercise expending 300 or 600 kcal, 5 days/weeks for 12 weeks. The reinforcing value of food (PMaxfood) was measured via a computer-based operant responding task and RRVfoodwas calculated as the reinforcing value of food relative to non-eating sedentary behaviors. RMR was determined by indirect calorimetry and body composition by DXA.

Results

Post-training FFM correlated with usual post-training EI (rs = 0.41,p < 0.05), PMaxfood(rs=0.52,p < 0.01), and RMR (rs = 0.85,p < 0.0001). ∆RMR negatively correlated with ∆PMaxfood(rs = − 0.38,p < 0.05) and with ∆RRVfood(rs = − 0.37,p < 0.05). ∆PMaxfoodand ∆RRVfoodwere not associated with ∆FFM (p = 0.71,p = 0.57, respectively).

Conclusions

Reductions in RMR with weight loss may increase food reinforcement as means of restoring FFM and RMR to pre-weight loss amounts. Limiting reductions in RMR during weight loss may benefit weight maintenance by restricting increases in food reinforcement after weight loss.
The Unequal Effects of Social Distancing Policy on Subway Ridership during the COVID-19 Pandemic in Seoul, South Korea
Authors: Ha Jaeyoung , Jo Suyoung , Nam Hee-kyoung , Cho Sung-il
Published: January 2022

In the Republic of Korea, social distancing policies relied on voluntary participation by citizens and exhibited short-term changes. In this situation, the effects of such policies varied depending on each community’s capacity to comply. Here, we collected subway ridership data for 294 stations on nine Seoul Metro lines and aggregated the data for each station to the 184 smallest administrative areas. We found that the mean percent change in subway ridership was fitted by an additive model of the log-transformed percent ratio of the restaurant industry (estimated degrees of freedom (EDF) = 3.24, P < 0.001), the Deprivation Index (DI) (EDF = 3.66, P = 0.015), and the proportion of essential workers (β =  − 0.10 (95% confidence interval − 0.15 to − 0.05, P < 0.001). We found a distinct decrease in subway ridership only in the least deprived areas, suggesting that social distancing is costly.
Radiotherapy for HPV-related cancers: prediction of therapeutic effects based on the mechanism of tumor immunity and the application of immunoradiotherapy
Authors: Someya Masanori , Fukushima Yuki , Hasegawa Tomokazu , Tsuchiya Takaaki , Kitagawa Mio , Gocho Toshio , Mafune Shoh , Ikeuchi Yutaro , Kozuka Yoh , Hirohashi Yoshihiko , Torigoe Toshihiko , Iwasaki Masahiro , Matsuura Motoki , Saito Tsuyoshi , Sakata Koh-ichi
Published: January 2022

Human papillomavirus (HPV)-related cancer is one of the diseases entities for which the applications of radiotherapy have been increasing. Recently, the process of carcinogenesis from HPV infection and the mechanism of tumor immunity that develops during disease progression have been elucidated. In this review, we will describe the mechanism of tumor immunity and how chemoradiotherapy may overcome and improve the efficacy of tumor immunity. We will also discuss the usefulness of proteins involved with tumor immunity as a predictive marker of radiotherapy response, and present an overview of ongoing clinical trials of combinations of immune checkpoint inhibitors and radiotherapy to demonstrate the promising combination therapy that has been currently emerging.
The missing intangibles: nature’s contributions to human wellbeing through place attachment and social capital
Authors: Yoshida Yuki , Matsuda Hirotaka , Fukushi Kensuke , Takeuchi Kazuhiko , Watanabe Ryugo
Published: January 2022

Communities in socio-ecological production landscapes and seascapes are aging and depopulating. While longstanding interdependence of humans and nature in such areas holds crucial hints for sustainable development, they continue to be undervalued by existing economic frameworks. We suspect omission of non-material nature’s contributions to people (NCPs) as a possible reason for this undervaluation and focus on the intangible aspects of human–nature relationships: people’s direct and emotional attachment to their land and interrelationships between close-knit human communities and a thriving natural environment. Field observations on Sado Island, Japan, and literature reviews informed our hypothesis that perceived nature, conceptual human–nature relationships, place attachment, and social relationships contribute to subjective wellbeing. Structural equation modeling of island-wide questionnaire responses confirmed our hypothesis. Nature contributes to wellbeing by enhancing place attachment and social relationships; ecocentrism contributes to greater values of perceived nature. Free-response comments elucidated how local foods and close interpersonal relationships enhance residents’ happiness and good quality of life, as well as how aging and depopulation impact their sense of loneliness. These results lend empirical support to the understanding of human–nature interdependency in socio-ecological production landscapes and seascapes. In assessing their value to local residents and society at large, greater consideration should be given to intangible aspects of human–nature relationships and quality of life.
Surveillance of pine wilt disease by high resolution satellite
Authors: Zhou Hongwei , Yuan Xinpei , Zhou Huanyu , Shen Hengyu , Ma Lin , Sun Liping , Fang Guofei , Sun Hong
Published: January 2022

Pine wilt disease caused by the pinewood nematode Bursaphelenchus xylophilus has led to the death of a large number of pine trees in China. This destructive disease has the characteristics of bring wide-spread, fast onset, and long incubation time. Most importantly, in China, the fatality rate in pines is as high as 100%. The key to reducing this mortality is how to quickly find the infected trees. We proposed a method of automatically identifying infected trees by a convolution neural network and bounding box tool. This method rapidly locates the infected area by classifying and recognizing remote sensing images obtained by high resolution earth observation Satellite. The recognition accuracy of the test data set was 99.4%, and the remote sensing image combined with convolution neural network algorithm can identify and determine the distribution of the infected trees. It can provide strong technical support for the prevention and control of pine wilt disease.
Cholinergic relevant functional reactivity is associated with dopamine responsiveness of tremor in Parkinson’s disease
Authors: Wu Jingjing , Zhou Cheng , Guo Tao , Guan Xiaojun , Gao Ting , Bai Xueqin , Wu Haoting , Chen Jingwen , Wen Jiaqi , Liu Xiaocao , Gu Luyan , Song Zhe , Xuan Min , Gu Quanquan , Huang Peiyu , Pu Jiali , Zhang Baorong , Xu Xiaojun , Zhang Minming
Published: January 2022

Tremor in Parkinson’s disease (PD) has distinct responsiveness to dopamine, which is supposed not be exclusively related to dopamine deficiency but has a close relationship with cholinergic system. This phenomenon indicates that cholinergic system may be an important regulatory for distinct dopamine responsiveness of parkinsonian tremor. Through investigating the alterations of cholinergic and dopaminergic network during levodopa administration, we aimed at exploring the mechanisms of differed dopamine responsiveness of parkinsonian tremor. Fifty-two PD patients with tremor were enrolled. MRI scanning, UPDRS III and its sub-symptom scores were collected in OFF and ON status (dopaminergic challenge test). Then, patients were divided into two groups (dopamine-resistant tremor and dopamine-responsive tremor) according to the tremor change rate median score. Dopaminergic and cholinergic network were obtained. LASSO regression was conducted to identify functional connectivity with distinct reactivity during levodopa administration between groups. Afterwards, detailed group comparisons, interaction and correlation analyses were performed. The reactivity of cholinergic connectivity showed the highest possibility to distinguish two groups, especially connectivity of right basal forebrain 123 to right parietal operculum cortex (R.BF123-R.PO). After levodopa administration, connectivity of R.BF123-R.PO was decreased for dopamine-responsive tremor while which remained unchanged for dopamine-resistant tremor. The reactivity of R.BF123-R.PO was negatively correlated with tremor change rate. Reduced cholinergic connectivity to parietal operculum may be an underlying mechanism for the responsive tremor in PD and the distinct cholinergic reactivity of parietal operculum to levodopa may be a core pathophysiology for the differed DA responsiveness of tremor in PD.
Health risks of adults in Hong Kong related to inhalation of particle-bound heavy metal(loid)s
Authors: Chen Xiaocui , Ward Tony J. , Sarkar Chinmoy , Ho Kin-Fai , Webster Chris
Published: January 2022

Heterogeneity between ambient and personal exposure to heavy metals has been documented. However, few studies have investigated potential health risks posed by inhalational exposure to airborne heavy metal(loid)s at the individual level. A total of 404 personal fine particles (PM2.5) samples were collected from 61 adult residents (aged 18–63 years) in Hong Kong during 2014–2015. Heavy metal(loid)s were analyzed using energy dispersive X-ray fluorescence. Among the analyzed heavy metal(loid)s, zinc (Zn) was the most abundant component in personal PM2.5, followed by lead (Pb), copper (Cu), and vanadium (V); cobalt (Co) and cadmium (Cd) were not detectable. Health risks of personal exposure to heavy metal(loid)s via inhalation were assessed for adults, including non-cancer risks that were characterized by hazard quotient (HQ) and hazard index (HI). The results indicated that non-cancer risks of heavy metal(loid)s were attributable to Cu, with a 95th HQ value > 1. Arsenic (As) and hexavalent chromium [Cr (VI)] were also significant contributors to inhalation cancer risks (> 1 × 10−6) for the adult participants. Finally, we employed a Monte Carlo simulation to evaluate the uncertainty associated with health risk assessment. The mean and median upper-bound lifetime cancer risk associated with inhalation exposure to carcinogenic heavy metal(loid)s exceeded the acceptable level (1 × 10−6) for adults. Traffic emission (including non-tailpipe exhaust), shipping emission, and regional pollution were significant sources of heavy metals. These findings suggest that emission controls targeting local vehicles and vessels should be given priority in Hong Kong.
Non-Muslims in the Qanun Jinayat and the Choice of Law in Sharia Courts in Aceh
Authors: Halim Abdul
Published: January 2022

The Aceh Jinayat Qanun, which is often considered violating Human Rights, has become the choice of the non-Muslim minorities as their rational choice. This study aims to analyze non-Muslims’ choice of The Aceh Jinayat Qanun implemented by the Sharia Court in Aceh and its underlying motives. This study relies on field research involving observations, in-depth interviews with Sharia Court judges, Head of the Islamic Sharia Service, Acehnese clerical figures, and Non-Muslims involved in criminal cases handled by the Sharia Courts. This study also analyzes Sharia Court decisions on criminal cases involving non-Muslims and various related documents issued by the Sharia Courts, police, and prosecutors. The study was undertaken between July 2017 and March 2020. The study shows that the Acehnese non-Muslims do not select The Aceh Jinayat Qanun because of its religious values but based on practicality, efficiency, and socio-cultural consideration. The Sharia-based sentences, which have often been conceived as inhuman and violate fundamental human rights, are chosen and become the rational choice for non-Muslims in solving their legal issues. This paper concludes that the implementation of the Sharia on non-Muslim has not always been negative. This paper demonstrates non-Muslims’ interest to choose Sharia-based criminal justice or The Aceh Jinayat Qanun over the Criminal Code. This can be seen as their rational choice over a more efficient, low-cost, effective, and fast legal process offered by The Aceh Jinayat Qanun sentencing system.
Cross-level effects of health-promoting leadership on nurse presenteeism: The mediation and moderation effect of workload and performance pressure
Authors: Shan Geyan , Wang Wei , Wang Shengnan , Zhang Yongjun , Li Yongxin
Published: January 2022

This study examines the cross-level influence mechanism of leaders’ health-promoting leadership on subordinates’ presenteeism among nursing industry. A multilevel mediated moderation model was hypothesized to explore whether health-promoting leadership is associated with subordinates’ presenteeism via the workload of subordinates, and how leader’s performance pressure plays the role in the model. Questionnaires were distributed to 110 nursing teams, which including 110 chief nurses and 660 subordinate nurses. Our findings showed that although health-promoting leadership has no direct impact on presenteeism, health-promoting leadership has an indirect impact on presenteeism via workload, and workload acts as a complete mediator. Meanwhile, performance pressure moderated the relationship between health-promoting leadership and workload. With an increase in performance pressure of leaders, the negative impact of health-promoting leadership on nurse workload gradually weakened. In this multilevel mediated moderation model, the mediated moderating effect of performance pressure was significant and the moderating effect was completely mediated, which means that the interaction between health-promoting leadership and performance pressure can affect presenteeism through workload. When leaders were under high performance pressure, the protective effect of health-promoting leadership on workload would be inhibited. These findings contribute to enriching the research on presenteeism, providing insight into how the health development of employees and performance demands of leaders may be balanced, and affording fresh thoughts for effective prevention and treatment of nurse presenteeism.
Salt Marsh Accretion With and Without Deep Soil Subsidence as a Proxy for Sea-Level Rise
Authors: van Dobben Han F. , de Groot Alma V. , Bakker Jan P.
Published: January 2022

The relation between salt marsh accretion and flooding regime was quantified by statistical analysis of a unique dataset of accretion measurements using sedimentation-erosion bars, on three barrier islands in the Dutch Wadden Sea over a period of c. 15 years. On one of the islands, natural gas extraction caused deep soil subsidence, which resulted in gradually increasing flooding frequency, duration, and depth, and can thus be seen as a proxy for sea-level rise. Special attention was paid to effects of small-scale variation e.g., in distance to tidal creeks or marsh edges, elevation of the marsh surface, and presence of livestock. Overall mean accretion rate was 0.44 ± 0.0005 cm year−1, which significantly exceeded the local rate of sea-level rise of 0.25 ± 0.009 cm year−1. A multiple regression approach was used to detect the combined effect of flooding regime and the local environment. The most important flooding-related factors that enhance accretion are mean water depth during flooding and overall mean water depth, but local accretion strongly decreases with increasing distance to the nearest creek or to the salt marsh edge. Mean water depth during flooding can be seen as an indicator for storm intensity, while overall mean water depth is a better indicator for storm frequency. The regression parameters were used to run a simple model simulating the effect of various sea-level scenarios on accretion and show that, even under extreme scenarios of sea-level rise, these salt marshes can probably persist for the next 100 years, although the higher parts may experience more frequent inundation.
Assessing the readiness of small cities in Ghana to tackle overweight and obesity
Authors: Aberman Noora-Lisa , Nisbett Nick , Amoafo Adjoa , Areetey Richmond
Published: January 2022

The rapid rise in the prevalence of overweight and obesity, and the associated health problems, is an emerging challenge in Ghana, and for women in particular. This study contributes to the understanding of this emerging phenomenon in Ghana by analyzing it from a community perspective, applying the Community Readiness Model in two small cities in Ghana. A series of Key Informant Interviews were undertaken and analyzed, using the model’s scoring structure and supplementary textual analysis. We find that communities are aware of overweight and obesity as a health issue, but that it is not prioritized or championed. Furthermore, the diet counseling and keep-fit programs put the responsibility on individuals to address, rather than considering the upstream and structural causes and solutions.
Finite State Graphon Games with Applications to Epidemics
Authors: Aurell Alexander , Carmona René , Dayanıklı Gökçe , Laurière Mathieu
Published: January 2022

We consider a game for a continuum of non-identical players evolving on a finite state space. Their heterogeneous interactions are represented with a graphon, which can be viewed as the limit of a dense random graph. A player’s transition rates between the states depend on their control and the strength of interaction with the other players. We develop a rigorous mathematical framework for the game and analyze Nash equilibria. We provide a sufficient condition for a Nash equilibrium and prove existence of solutions to a continuum of fully coupled forward-backward ordinary differential equations characterizing Nash equilibria. Moreover, we propose a numerical approach based on machine learning methods and we present experimental results on different applications to compartmental models in epidemiology.
Exosomal targeting and its potential clinical application
Authors: He Jiao , Ren Weihong , Wang Wei , Han Wenyan , Jiang Lu , Zhang Dai , Guo Mengqi
Published: January 2022

Exosomes are extracellular vesicles secreted by a variety of living cells, which have a certain degree of natural targeting as nano-carriers. Almost all exosomes released by cells will eventually enter the blood circulation or be absorbed by other cells. Under the action of content sorting mechanism, some specific surface molecules can be expressed on the surface of exosomes, such as tetraspanins protein and integrin. To some extent, these specific surface molecules can fuse with specific cells, so that exosomes show specific cell natural targeting. In recent years, exosomes have become a drug delivery system with low immunogenicity, high biocompatibility and high efficacy. Nucleic acids, polypeptides, lipids, or small molecule drugs with therapeutic function are organically loaded into exosomes, and then transported to specific types of cells or tissues in vivo, especially tumor tissues, to achieve targeting drug delivery. The natural targeting of exosome has been found and recognized in some studies, but there are still many challenges in effective clinical treatments. The use of the natural targeting of exosomes alone is incapable of accurately transporting the goods loaded to specific sites. Besides, the natural targeting of exosomes is still an open question in disease targeting and efficient gene/chemotherapy combined therapy. Engineering transformation and modification on exosomes can optimize its natural targeting and deliver the goods to a specific location, providing wide use in clinical treatment. This review summarizes the research progress of exosomal natural targeting and transformation strategy of obtained targeting after transformation. The mechanism of natural targeting and obtained targeting after transformation are also reviewed. The potential value of exosomal targeting in clinical application is also discussed.

Graphical abstract
Biodegradable nanoparticles combining cancer cell targeting and anti-angiogenic activity for synergistic chemotherapy in epithelial cancer
Authors: Moret Francesca , Conte Claudia , Esposito Diletta , Dal Poggetto Giovanni , Avitabile Concetta , Ungaro Francesca , Tiso Natascia , Romanelli Alessandra , Laurienzo Paola , Reddi Elena , Quaglia Fabiana
Published: January 2022

A biodegradable engineered nanoplatform combining anti-angiogenic activity and targeting of cancer cells to improve the anticancer activity of docetaxel (DTX) is here proposed. Indeed, we have developed biodegradable nanoparticles (NPs) of poly(ethylene glycol)-poly(ε-caprolactone), exposing on the surface both folate motifs (Fol) for recognition in cells overexpressing Folate receptor-α (FRα) and the anti-angiogenic hexapeptide aFLT1. NPs showed a size around 100 nm, the exposure of 60% of Fol moieties on the surface, and the ability to entrap DTX and sustain its release with time. NPs were stable in simulated biological fluids and slightly interacted with Fetal Bovine serum, especially in the formulation decorated with Fol and aFLT1. The presence of Fol on NPs did not impair the anti-angiogenic activity of aFLT1, as assessed by in vitro tube formation assay in HUVEC endothelial cells. In both 2D and 3D KB cell cultures in vitro, the cytotoxicity of DTX loaded in NPs was not significantly affected by Fol/aFLT1 double decoration compared to free DTX. Remarkably, NPs distributed differently in 3D multicellular spheroids of FRα-positive KB cancer cells depending on the type of ligand displayed on the surface. In particular, NPs unmodified on the surface were randomly distributed in the spheroid, whereas the presence of Fol promoted the accumulation in the outer rims of the spheroid. Finally, NPs with Fol and aFLT1 gave a uniform distribution throughout the spheroid structure. When tested in zebrafish embryos xenografted with KB cells, NPs displaying Fol/aFLT1 reduced DTX systemic toxicity and inhibited the growth of the tumor mass and associated vasculature synergistically. Overall, nanotechnology offers excellent ground for combining therapeutic concepts in cancer, paving the way to novel multifunctional nanopharmaceuticals decorated with bioactive elements that can significantly improve therapeutic outcomes.

Graphical abstract
Dismantling white supremacy in environmental studies and sciences: an argument for anti-racist and decolonizing pedagogies
Authors: Bratman Eve Z. , DeLince William P.
Published: January 2022

Many academic disciplines are presently striving to reveal and dismantle structures of domination by working to reform and reimagine their curricula, and the ethics and values that underpin classroom settings. This trend is impelled by momentum from the Black Lives Matter movement in tandem with a worldwide call from Indigenous scholars and their allies for more equality in research and epistemological plurality. We contribute to such efforts through applying perspective and analysis concerning anti-racist and decolonized approaches to teaching environmental studies and sciences (ESS). This article discusses the opportunities and challenges of embracing a decolonized and anti-racist approach with an emphasis on courses in higher education in North America. We conclude with guidance for educators about strategies for incorporating such approaches.
Isolation of High Purity Mouse Mesenchymal Stem Cells through Depleting Macrophages Using Liposomal Clodronate
Authors: Song Ju Han , Kim Jung-Woo , Lee Mi Nam , Oh Sin-Hye , Piao Xianyu , Wang Zhao , Kwon Seung-Hee , Kim Ok-Su , Koh Jeong-Tae
Published: January 2022

BACKGROUND:

The use of mouse bone marrow mesenchymal stem cells (mBMSCs) represents a promising strategy for performing preclinical studies in the field of cell-based regenerative medicine; however, mBMSCs obtained via conventional isolation methods have two drawbacks, i.e., (i) they are heterogeneous due to frequent macrophage contamination, and (ii) they require long-term culturing for expansion.

METHODS:

In the present study, we report a novel strategy to generate highly pure mBMSCs using liposomal clodronate. This approach is based on the properties of the two cell populations, i.e., BMSCs (to adhere to the plasticware in culture dishes) and macrophages (to phagocytose liposomes).

RESULTS:

Liposomal clodronate added during the first passage of whole bone marrow culture was selectively engulfed by macrophages in the heterogeneous cell population, resulting in their effective elimination without affecting the MSCs. This method allowed the generation of numerous high-purity Sca-1+CD44+F4/80− mBMSCs (> 95%) with just one passaging. Comparative studies with mBMSCs obtained using conventional methods revealed that the mBMSCs obtained in the present study had remarkably improved experimental utilities, as demonstrated by in vitro multilineage differentiation and in vivo ectopic bone formation assays.

CONCLUSION:

Our newly developed method, which enables the isolation of mBMSCs using simple and convenient protocol, will aid preclinical studies based on the use of MSCs.
Implicit Racial Attitudes and Associations Among Obstetricians in Hawaiʻi: a Pilot Study
Authors: Delafield Rebecca , Hermosura Andrea , Ahn Hyeong Jun , Kaholokula Joseph Keaweʻaimoku
Published: January 2022

Introduction

Pacific Islanders living in Hawai‘i with ancestral ties to islands in the western Pacific region of Micronesia are common targets of uninhibited forms of prejudice in multiple sectors, including healthcare. Whether the explicit societal-level attitudes toward this group are reflected in implicit attitudes among healthcare providers is unknown; therefore, we designed a pilot study to investigate this question. Our study measures implicit racial bias toward Pacific Islanders from Micronesia among Obstetrician-Gynecologists (OB-GYNs) in Hawai‘i.

Methods

We developed 4 new implicit association tests (IATs) to measure implicit attitudes and associations (i.e., stereotypes) toward Pacific Islanders from Micronesia in 2 conditions: (1) Micronesians vs. Whites and (2) Micronesians vs. Japanese Americans. Participants were practicing OB-GYNs in Hawai‘i. The study was conducted online and included survey questions on demographic and physician practice characteristics in addition to IATs. The primary outcome was the mean IAT D score. Associations between IAT D scores and demographic and practice characteristics were also analyzed.

Results

Of the 49 OB-GYNs, 38 (77.6%) were female, mean age was 40 years, 29.5% were Japanese, 22.7% were White, and none were from a Micronesian ethnic group. The mean IAT D score in the Micronesian vs. White condition (N = 29) was 0.181, (SD: 0.465, p < 0.05) for the Attitude IAT and 0.197 (SD: 0.427; p < 0.05) for the Stereotype IAT.

Conclusion

The findings from this pilot suggest a slight degree of implicit bias favoring Whites over Micronesians within this sample of OB-GYNs and warrant a larger investigation into implicit biases toward this unique and understudied Pacific Islander population.
Long-term high-dose l-arginine supplementation in patients with vasculogenic erectile dysfunction: a multicentre, double-blind, randomized, placebo-controlled clinical trial
Authors: Menafra D. , de Angelis C. , Garifalos F. , Mazzella M. , Galdiero G. , Piscopo M. , Castoro M. , Verde N. , Pivonello C. , Simeoli C. , Auriemma R. S. , Colao A. , Pivonello R.
Published: January 2022

Purpose

The current randomized, double-blind, placebo-controlled clinical trial addressed the effects on penile erectile function of relatively high daily oral doses (6 g/day) of l-ARG for 3 months (N = 51) compared to placebo (N = 47), in patients with vasculogenic ED, with comparison between mild–moderate and severe vasculogenic ED.

Methods

The outcome measures included IIEF-6 score and cavernous arteries peak systolic flow velocity (PSV) at dynamic penile duplex ultrasonography (PDU).

Results

l-ARG supplementation for 3 months significantly increased IIEF-6 score in the overall cohort (p < 0.0001) and in subgroups of patients with mild–moderate (p < 0.0001) and severe (p = 0.007) vasculogenic ED; PSV was significantly increased in the overall cohort (p < 0.0001) and in patients with mild–moderate (p < 0.0001), but not severe vasculogenic ED. At study completion, 74% of patients improved ED degree category, although only 24% of patients, mainly belonging to the baseline category of mild ED, reached IIEF-6 scores compatible with absence of ED; moreover, 20% of patients, exclusively belonging to the baseline category of mild–moderate vasculogenic ED, reached PSV values compatible with absence of ED.

Conclusion

The results of the current study demonstrated that supplementation with relatively high doses of l-ARG as a single compound for 3 months significantly improved penile erectile function, assessed by both IIEF-6 score and PSV at dynamic PDU in patients with mild–moderate, and improved IIEF-6 score, but not PSV, in patients with severe vasculogenic ED, therefore suggesting that l-ARG might be an alternative treatment in mild–moderate vasculogenic ED patients experiencing adverse effects or with contraindications for chronic treatment with PDE5i compounds.
An accurate star identification approach based on spectral graph matching for attitude measurement of spacecraft
Authors: You Zhiyuan , Li Junzheng , Zhang Hongcheng , Yang Bo , Le Xinyi
Published: January 2022

Star identification is the foundation of star trackers, which are used to precisely determine the attitude of spacecraft. In this paper, we propose a novel star identification approach based on spectral graph matching. In the proposed approach, we construct a feature called the neighbor graph for each main star, transforming the star identification to the problem of finding the most similar neighbor graph. Then the rough search and graph matching are cooperated to form a dynamic search framework to solve the problem. In the rough search stage, the total edge weight in the minimum spanning tree of the neighbor graph is selected as an indicator, then the k-vector range search is applied for reducing the search scale. Spectral graph matching is utilized to achieve global matching, identifying all stars in the neighbor circle with good noise-tolerance ability. Extensive simulation experiments under the position noise, lost-star noise, and fake-star noise show that our approach achieves higher accuracy (mostly over 99%) and better robustness results compared with other baseline algorithms in most cases.
Multiobjective multitasking optimization assisted by multidirectional prediction method
Authors: Dang Qianlong , Gao Weifeng , Gong Maoguo
Published: January 2022

Multiobjective multitasking optimization (MTO) is an emerging research topic in the field of evolutionary computation, which has attracted extensive attention, and many evolutionary multitasking (EMT) algorithms have been proposed. One of the core issues, designing an efficient transfer strategy, has been scarcely explored. Keeping this in mind, this paper is the first attempt to design an efficient transfer strategy based on multidirectional prediction method. Specifically, the population is divided into multiple classes by the binary clustering method, and the representative point of each class is calculated. Then, an effective prediction direction method is developed to generate multiple prediction directions by representative points. Afterward, a mutation strength adaptation method is proposed according to the improvement degree of each class. Finally, the predictive transferred solutions are generated as transfer knowledge by the prediction directions and mutation strengths. By the above process, a multiobjective EMT algorithm based on multidirectional prediction method is presented. Experiments on two MTO test suits indicate that the proposed algorithm is effective and competitive to other state-of-the-art EMT algorithms.