bluuebunny/crossref_metadata_2025 huggingface dataset:
A Retrospective Analysis of the Role of Proton Pump Inhibitors in Colorectal Cancer Disease Survival
Authors: Graham C. , Orr C. , Bricks C.S. , Hopman W.M. , Hammad N. , Ramjeesingh R.
Published: December 2016

Background: Proton pump inhibitors (PPIS) are a commonly used medication. A limited number of studies have identified a weak-to-moderate association between PPI use and colorectal cancer (CRC) risk, but none to date have identified an effect of PPI use on CRC survival. We therefore postulated that an association between PPI use and CRC survival might potentially exist. Methods: We performed a retrospective chart review of 1304 CRC patients diagnosed from January 2005 to December 2011 and treated at the Cancer Centre of Southeastern Ontario. Kaplan–Meier analysis and Cox proportional hazards regression models were used to evaluate overall survival (OS). Results: We identified 117 patients (9.0%) who were taking PPIS at the time of oncology consult. Those taking a PPI were also more often taking ASA or statins (or both) and had a statistically significantly increased rate of cardiac disease. No identifiable difference in tumour characteristics was evident in the two groups, including tumour location, differentiation, lymph node status, and stage. Univariate analysis identified a statistically nonsignificant difference in survival, with those taking a PPI experiencing lesser 1-year (82.1% vs. 86.7%, p = 0.161), 2-year (70.1% vs. 76.8%, p = 0.111), and 5-year os (55.2% vs. 62.9%, p = 0.165). When controlling for patient demographics and tumour characteristics, multivariate Cox regression analysis identified a statistically significant effect of PPI in our patient population (hazard ratio: 1.343; 95% confidence interval: 1.011 to 1.785; p = 0.042). Conclusions: Our results suggest a potential adverse effect of PPI use on OS in CRC patients. These results need further evaluation in prospective analyses.
Treatment Patterns and Survival in Patients with ALK-Positive Non-small-Cell Lung Cancer: A Canadian Retrospective Study
Authors: Kayaniyil S. , Hurry M. , Wilson J. , Wheatley-Price P. , Melosky B. , Rothenstein J. , Cohen V. , Koch C. , Zhang J. , Osenenko K. , Liu G.
Published: December 2016

Background Crizotinib was the first agent approved for the treatment of anaplastic lymphoma kinase (ALK)– positive (+) non-small-cell lung cancer (NSCLC), followed by ceritinib. However, patients eventually progress or develop resistance to crizotinib. With limited real-world data available, the objective of the present work was to evaluate treatment patterns and survival after crizotinib in patients with locally advanced or metastatic ALK+ NSCLC in Canada. Methods In this retrospective study at 6 oncology centres across Canada, medical records of patients with locally advanced or metastatic ALK+ NSCLC were reviewed. Demographic and clinical characteristics, treatments, and outcomes data were abstracted. Analyses focused on patients who discontinued crizotinib treatment. Results Of the 97 patients included, 9 were crizotinib-naïve, and 39 were still receiving crizotinib at study end. The 49 patients who discontinued crizotinib treatment were included in the analysis. Of those 49 patients, 43% received ceritinib at any time, 20% subsequently received systemic chemotherapy only (but never ceritinib), and 37% received no further treatment or died before receiving additional treatment. Median overall survival from crizotinib discontinuation was shorter in patients who did not receive ceritinib than in those who received ceritinib (1.7 months vs. 20.4 months, p < 0.001). In a multivariable analysis, factors associated with poorer survival included lack of additional therapies (particularly ceritinib), male sex, and younger age, but not smoking status; patients of Asian ethnicity showed a nonsignificant trend toward improved survival. Conclusions A substantial proportion of patients with ALK+ NSCLC received no further treatment or died before receiving additional treatment after crizotinib. Treatment with systemic agents was associated with improved survival, with ceritinib use being associated with the longest survival.
Treatment and Outcomes for Primary Cutaneous Extramedullary Plasmacytoma: A Case Series
Authors: Tsang D.S. , Le L.W. , Kukreti V. , Sun A.
Published: December 2016

Background Primary cutaneous plasmacytoma (pcp) is a rare disease, with few studies to guide therapy. Our primary study objective was to define treatments used for pcp; a secondary objective was to describe outcomes of patients, including disease recurrence and death. Methods An institutional cancer registry was used to identify cases for retrospective chart review. In a systematic review, treatments for, and outcomes of, all known cases of pcp were described. Results Three eligible cases identified at our institution; each patient had a solitary pcp. The systematic review identified 66 patients. Radiotherapy was the most commonly used primary treatment modality (31% of all patients; 42% for patients with solitary lesions), followed by surgery (28% of all patients; 36% for patients with solitary lesions). Median survival for all patients was 10.4 years [95% CI: 4.3 years to not reached], with a trend toward a decreased risk of death with solitary lesions compared with multiple lesions (hazard ratio: 0.37; 95% CI: 0.13 to 1.08; p = 0.059). For patients with solitary lesions, the median and recurrence-free survivals were, respectively, 17.0 years (95% CI: 1.7 years to not reached) and 11.0 years (95% CI: 2 years to not reached); for patients with multiple lesions, they were 4.3 years (95% CI: 1.3 to not reached) and 1.4 years (95% CI: 0.6 years to not reached). Disease recurrence, including progression to multiple myeloma, was the most common cause of death. Conclusions Compared with patients having multiple pcp lesions, those presenting with a single pcp lesion might experience longer overall survival. Local therapy (radiation or surgery) is a reasonable curative treatment for a solitary pcp lesion.
Risk Stratification, Treatment Selection, and Transplant Eligibility in Multiple Myeloma: A Qualitative Study of the Perspectives and Self-Reported Practices of Oncologists
Authors: LeBlanc T.W. , Howson A. , Turell W. , Sheldon P. , Locke S.C. , Tuchman S.A. , Gasparetto C. , Kaura S. , Khan Z.M. , Abernethy A.P.
Published: December 2016

Background Since the early 2000s, treatment options for multiple myeloma have rapidly expanded, adding significant complexity to the management of this disease. To our knowledge, no systematic qualitative research on clinical decision-making in multiple myeloma has been published. We sought to characterize how physicians view and implement guidelines and incorporate novel approaches into patient care. Methods We designed a semi-structured qualitative interview guide informed by literature review and an expert advisory panel. We conducted 60-minute interviews with a diverse sample of oncology physicians in the southeast United States. We used a constant comparative method to code and analyze interview transcripts. The research team and advisory panel discussed and validated emergent themes. Results Participants were 13 oncologists representing 5 academic and 4 community practices. Academic physicians reported using formal risk-stratification schemas; community physicians typically did not. Physicians also described differences in eligibility criteria for transplantation; community physicians emphasized distance, social support, and psychosocial capacity in making decisions about transplantation referral; the academic physicians reported using more specific clinical criteria. All physicians reported using a maintenance strategy both for post-transplant and for transplant-ineligible patients; however, determining the timing of maintenance therapy initiation and the response were reported as challenging, as was recognition or definition of relapse, especially in terms of when treatment re-initiation is indicated. Conclusions Practices reported by both academic and community physicians suggest opportunities for interventions to improve patient care and outcomes through optimal multiple myeloma management and therapy selection. Community physicians in particular might benefit from targeted education interventions about risk stratification, transplant eligibility, and novel therapies.
The Risk of Colorectal Cancer Is Not Increased after a Diagnosis of Urothelial Cancer: A Population-Based Study
Authors: Harlos C.H. , Singh H. , Nugent Z. , Demers A. , Mahmud S.M. , Czaykowski P.M.
Published: December 2016

Background The data about whether patients with a prior urothelial cancer (UCa) are at increased risk of colorectal cancer (CRC) are conflicting. We used a competing risks analysis to determine the risk of CRC after UCa. Methods Historical cohorts were assembled by record linkage of Manitoba Cancer Registry and Manitoba Health databases. The incidence of CRC for individuals with UCa as their first cancer between 1987 and 2009 was compared with the incidence for randomly selected age- and sex-matched individuals without a cancer diagnosis at the index date (UCa diagnosis date). Three competing outcomes (CRC, another primary cancer, and death) were evaluated by competing risks proportional hazards models with adjustment for relevant confounders. Results The cohorts of 4591 patients with UCa and 22,312 without UCa were followed for a total of 179,287 person– years (py). After UCa, the rate of subsequent colon cancer in UCa patients was 4.5 per 1000 py compared with 3.6 per 1000 py in the non-cancer cohort. In the multivariable analysis, no overall increase in CRC risk was observed for patients first diagnosed with UCa (hazard ratio: 0.88; 95% confidence interval: 0.70 to 1.1; p = 0.26). Conclusions Because of similar CRC risk, a similar CRC screening strategy should be applied for individuals with and without UCa.
Cancer Care in South India: Perspectives from Visiting Canadian Oncologists
Authors: Karim S. , Del Paggio J.C. , Berry S.R. , Booth C.M.
Published: December 2016

Cancer is recognized as an increasing threat to public health in low- and middle-income countries (lMICS).[...]
Organofluorine chemistry: Difluoromethylene motifs spaced 1,3 to each other imparts facial polarity to a cyclohexane ring
Authors: Jones Mathew J , Callejo Ricardo , Slawin Alexandra M Z , Bühl Michael , O'Hagan David
Published: December 2016

2,2-Dimethyl-5-phenyl-1,1,3,3-tetrafluororocyclohexane has been prepared and characterised as an example of a facially polarised cyclohexane containing 1,3 related CF2 groups. The dipolar nature of the ring arises from the axial orientation of two of the C–F bonds pointing in the same direction, and set by the chair conformation of the cyclohexane. This electrostatic profile is revealed experimentally both in the solid-state (X-ray) packing of the rings and by solution (NMR) in different solvents. A computationally derived electrostatic profile of this compound is consistent with a more electronegative and a more electropositive face of the cyclohexane ring. This placing of CF2 groups 1,3 to each other in a cyclohexane ring is introduced as a new design strategy which could be applicable to the preparation of polar hydrophobic cyclohexane motifs.
Safe Use of Acoustic Vestibular-Evoked Myogenic Potential Stimuli: Protocol and Patient-Specific Considerations
Authors: Portnuff Cory D. F. , Kleindienst Samantha , Bogle Jamie M.
Published: December 2016

Background:Vestibular-evoked myogenic potentials (VEMPs) are commonly used clinical assessments for patients with complaints of dizziness. However, relatively high air-conducted stimuli are required to elicit the VEMP, and ultimately may compromise safe noise exposure limits.
Recently, research has reported the potential for noise-induced hearing loss (NIHL) from VEMP stimulus exposure through studies of reduced otoacoustic emission levels after VEMP testing, as well as a recent case study showing permanent sensorineural hearing loss associated with VEMP exposure.Purpose:The
purpose of this report is to review the potential for hazardous noise exposure from VEMP stimuli and to suggest clinical parameters for safe VEMP testing.Research Design:Literature review with presentation of clinical guidelines and a clinical tool for estimating noise exposure.Results:The
literature surrounding VEMP stimulus-induced hearing loss is reviewed, including several cases of overexposure. The article then presents a clinical calculation tool for the estimation of a patient’s safe noise exposure from VEMP stimuli, considering stimulus parameters, and includes
a discussion of how varying stimulus parameters affect a patient’s noise exposure. Finally, recommendations are provided for recognizing and managing specific patient populations who may be at higher risk for NIHL from VEMP stimulus exposure. A sample protocol is provided that allows
for safe noise exposure.Conclusions:VEMP stimuli have the potential to cause NIHL due to high sound exposure levels. However, with proper safety protocols in place, clinicians may reduce or eliminate this risk to their patients. Use of the tools provided, including the noise exposure
calculation tool and sample protocols, may help clinicians to understand and ensure safe use of VEMP stimuli.
BINARY CENTRAL STARS OF PLANETARY NEBULAE DISCOVERED THROUGH PHOTOMETRIC VARIABILITY. V. THE CENTRAL STARS OF HaTr 7 AND ESO 330-9
Authors: Hillwig Todd C. , Frew David J. , Reindl Nicole , Rotter Hannah , Webb Andrew , Margheim Steve
Published: December 2016

We find the central stars (CSs) of the planetary nebulae (PNe) HaTr 7 and ESO 330-9 to be close-binary systems. Both have orbital periods of less than half a day and contain an irradiated cool companion to the hot CS. We provide light curves, spectra, radial velocity curves, orbital periods, and binary modeling results for both systems. The binary modeling leads to system parameters, or ranges of allowed parameters for each system. We find that for the CS of HaTr 7 we need to use limb-darkening values for the cool companion that are different than the expected values for an isolated star. We also fit the CS spectrum to determine

and temperature values independent of the binary modeling. For ESO 330-9 we find that based on our binary modeling, the hot CS is most likely a post-red giant branch (RGB) star with a mass of around 0.4

. We discuss our derived stellar and nebular parameters in the broader context of close-binary CSs and their surrounding planetary nebulae (PNe). We also discuss the present status of known or suspected post-RGB stars in PNe.
GMOSS: ALL-SKY MODEL OF SPECTRAL RADIO BRIGHTNESS BASED ON PHYSICAL COMPONENTS AND ASSOCIATED RADIATIVE PROCESSES
Authors: Rao Mayuri Sathyanarayana , Subrahmanyan Ravi , Shankar N Udaya , Chluba Jens
Published: December 2016

We present the Global Model for the Radio Sky Spectrum (GMOSS), a novel, physically motivated model of the low-frequency radio sky from 22 MHz to 23 GHz. GMOSS invokes different physical components and associated radiative processes to describe the sky spectrum over 3072 pixels of 5° resolution. The spectra are allowed to be convex, concave, or of more complex form with contributions from synchrotron emission, thermal emission, and free–free absorption included. Physical parameters that describe the model are optimized to best fit four all-sky maps at 150 MHz, 408 MHz, 1420 MHz, and 23 GHz and two maps at 22 and 45 MHz generated using the Global Sky Model of de Oliveira-Costa et al. The fractional deviation of the model from data has a median value of 6% and is less than 17% for 99% of the pixels. Though aimed at the modeling of foregrounds for the global signal arising from the redshifted 21 cm line of hydrogen during the Cosmic Dawn and the Epoch of Reionization (EoR), over redshifts

, GMOSS is well suited for any application that requires simulating spectra of the low-frequency radio sky as would be observed by the beam of any instrument. The complexity in spectral structure that naturally arises from the underlying physics of the model provides a useful expectation for departures from smoothness in EoR foreground spectra and hence may guide the development of algorithms for EoR signal detection. This aspect is further explored in a subsequent paper.
PREDICTION OF SOLAR FLARES USING UNIQUE SIGNATURES OF MAGNETIC FIELD IMAGES
Authors: Raboonik Abbas , Safari Hossein , Alipour Nasibe , Wheatland Michael S.
Published: December 2016

Prediction of solar flares is an important task in solar physics. The occurrence of solar flares is highly dependent on the structure and topology of solar magnetic fields. A new method for predicting large (M- and X-class) flares is presented, which uses machine learning methods applied to the Zernike moments (ZM) of magnetograms observed by the Helioseismic and Magnetic Imager on board the Solar Dynamics Observatory for a period of six years from 2010 June 2 to 2016 August 1. Magnetic field images consisting of the radial component of the magnetic field are converted to finite sets of ZMs and fed to the support vector machine classifier. ZMs have the capability to elicit unique features from any 2D image, which may allow more accurate classification. The results indicate whether an arbitrary active region has the potential to produce at least one large flare. We show that the majority of large flares can be predicted within 48 hr before their occurrence, with only 10 false negatives out of 385 flaring active region magnetograms and 21 false positives out of 179 non-flaring active region magnetograms. Our method may provide a useful tool for the prediction of solar flares, which can be employed alongside other forecasting methods.
MERGER-INDUCED SHOCKS IN THE NEARBY LIRG VV 114 THROUGH METHANOL OBSERVATIONS WITH ALMA
Authors: Saito Toshiki , Iono Daisuke , Espada Daniel , Nakanishi Kouichiro , Ueda Junko , Sugai Hajime , Takano Shuro , Yun Min S. , Imanishi Masatoshi , Ohashi Satoshi , Lee Minju , Hagiwara Yoshiaki , Motohara Kentaro , Kawabe Ryohei
Published: December 2016

We report the detection of two CH3OH lines (J

K
= 2
K
–1
K
and 3
K
–2
K
) between the progenitor’s disks (“Overlap”) of the mid-stage merging galaxy VV 114 obtained using the Atacama Large Millimeter/submillimeter Array (ALMA) Band 3 and Band 4. The detected CH3OH emission shows an extended filamentary structure (∼3 kpc) across the progenitor’s disks with relatively large velocity width (FWZI ∼ 150 km s−1). The emission is only significant in the “overlap” and not detected in the two merging nuclei. Assuming optically thin emission and local thermodynamic equilibrium, we found the CH3OH column density relative to H2 (

) peaks at the “Overlap” (∼8 × 10−9), which is almost an order of magnitude larger than that at the eastern nucleus. We suggest that kpc-scale shocks driven by galaxy–galaxy collision may play an important role to enhance the CH3OH abundance at the “Overlap.” This scenario is consistent with shock-induced large velocity dispersion components of ionized gas that have been detected in optical wavelength at the same region. Conversely, low

at the nuclear regions might be attributed to the strong photodissociation by nuclear starbursts and/or a putative active galactic nucleus, or inefficient production of CH3OH on dust grains due to initial high-temperature conditions (i.e., desorption of the precursor molecule, CO, into gas phase before forming CH3OH on dust grains). These ALMA observations demonstrate that CH3OH is a unique tool to address kpc-scale shock-induced gas dynamics and star formation in merging galaxies.
TIDAL ORIGIN OF SPIRAL ARMS IN GALAXIES ORBITING A CLUSTER
Authors: Semczuk Marcin , Łokas Ewa L. , Pino Andrés del
Published: December 2016

One of the scenarios for the formation of grand-design spiral arms in disky galaxies involves their interactions with a satellite or another galaxy. Here we consider another possibility, where the perturbation is instead due to the potential of a galaxy cluster. Using N-body simulations we investigate the formation and evolution of spiral arms in a Milky-Way-like galaxy orbiting a Virgo-like cluster. The galaxy is placed on a few orbits of different size but similar eccentricity and its evolution are followed for 10 Gyr. The tidally induced, two-armed, approximately logarithmic spiral structure forms on each of them during the pericenter passages. The spiral arms dissipate and wind up with time, to be triggered again at the next pericenter passage. We confirm this transient and recurrent nature of the arms by analyzing the time evolution of the pitch angle and the arm strength. We find that the strongest arms are formed on the tightest orbit; however, they wind up rather quickly and are disturbed by another pericenter passage. The arms on the most extended orbit, which we analyze in more detail, wind up slowly and survive for the longest time. Measurements of the pattern speed of the arms indicate that they are kinematic density waves. We attempt a comparison with observations by selecting grand-design spiral galaxies in the Virgo cluster. Among those, we find nine examples bearing no sign of recent interactions or the presence of companions. For three of them we present close structural analogues among our simulated spiral galaxies.
APPROACHING THE CRAMÉR–RAO BOUND IN WEAK LENSING WITH PDF SYMMETRIZATION
Authors: Zhang Jun , Zhang Pengjie , Luo Wentao
Published: December 2016

Weak lensing statistics is typically measured as the weighted sum of shear estimators or their products (shear–shear correlation). The weighting schemes are designed with a view to minimizing the statistical error without introducing systematic errors. It would be ideal to approach the Cramér–Rao bound (the lower bound of the statistical uncertainty) in shear statistics, though it is generally difficult to do so in practice. The reasons may include difficulties in galaxy shape measurement, inaccurate knowledge of the probability distribution function (PDF) of the shear estimator, misidentification of point sources as galaxies, etc. Using the shear estimators defined by Zhang et al., we show that one can overcome these problems, and allow shear measurement accuracy to approach the Cramér–Rao bound. This can be achieved by symmetrizing the PDF of the shear estimator, or the joint PDF of shear estimator pairs (for shear–shear correlation), without any prior knowledge of the PDF. Using simulated galaxy images, we demonstrate that under general observing conditions, this idea works as expected: it minimizes the statistical uncertainty without introducing systematic error.
New records and detailed distribution and abundance of selected arthropod species collected between 1999 and 2011 in Azorean native forests
Authors: Borges Paulo , Gaspar Clara , Crespo Luís Carlos , Rigal François , Cardoso Pedro , Pereira Fernando , Rego Carla , Amorim Isabel , Melo Catarina , Aguiar Carlos , André Genage , Mendonça Enésima , Ribeiro Sérvio , Hortal Joaquín , Santos Ana , Barcelos Luís , Enghoff Henrik , Mahnert Volker , Pita Margarida , Ribes Jordi , Baz Arturo , Sousa António , Vieira Virgílio , Wunderlich Jörg , Parmakelis Aristeidis , Whittaker Robert , Quartau José Alberto , Serrano Artur , Triantis Kostas
Published: December 2016

In this contribution we present detailed distribution and abundance data for arthropod species identified during the BALA – Biodiversity of Arthropods from the Laurisilva of the Azores (1999-2004) and BALA2 projects (2010-2011) from 18 native forest fragments in seven of the nine Azorean islands (all excluding Graciosa and Corvo islands, which have no native forest left).

Of the total 286 species identified, 81% were captured between 1999 and 2000, a period during which only 39% of all the samples were collected. On average, arthropod richness for each island increased by 10% during the time frame of these projects. The classes Arachnida, Chilopoda and Diplopoda represent the most remarkable cases of new island records, with more than 30% of the records being novelties. This study stresses the need to expand the approaches applied in these projects to other habitats in the Azores, and more importantly to other less surveyed taxonomic groups (e.g. Diptera and Hymenoptera). These steps are fundamental for getting a more accurate assessment of biodiversity in the archipelago.
Rescuing biogeographic legacy data: The "Thor" Expedition, a historical oceanographic expedition to the Mediterranean Sea
Authors: Mavraki Dimitra , Fanini Lucia , Tsompanou Marilena , Gerovasileiou Vasilis , Nikolopoulou Stamatina , Chatzinikolaou Eva , Plaitis Wanda , Faulwetter Sarah
Published: December 2016

This article describes the digitization of a series of historical datasets based οn the reports of the 1908–1910 Danish Oceanographical Expeditions to the Mediterranean and adjacent seas. All station and sampling metadata as well as biodiversity data regarding calcareous rhodophytes, pelagic polychaetes, and fish (families Engraulidae and Clupeidae) obtained during these expeditions were digitized within the activities of the LifeWatchGreece Research Ιnfrastructure project and presented in the present paper. The aim was to safeguard public data availability by using an open access infrastructure, and to prevent potential loss of valuable historical data on the Mediterranean marine biodiversity.

The datasets digitized here cover 2,043 samples taken at 567 stations during a time period from 1904 to 1930 in the Mediterranean and adjacent seas. The samples resulted in 1,588 occurrence records of pelagic polychaetes, fish (Clupeiformes) and calcareous algae (Rhodophyta). In addition, basic environmental data (e.g. sea surface temperature, salinity) as well as meterological conditions are included for most sampling events. In addition to the description of the digitized datasets, a detailed description of the problems encountered during the digitization of this historical dataset and a discussion on the value of such data are provided.
Parasitism of Hymenoepimecis manauara Pádua & Oliveira (Hymenoptera: Ichneumonidae: Pimplinae) on Leucauge henryi Mello-Leitão (Araneae: Tetragnathidae) in Brazilian Amazonian
Authors: Pádua Diego , Salvatierra Lidianne , Sobczak Jober , Oliveira Marcio
Published: December 2016

A parasitoid wasp Hymenoepimecis manauara Pádua & Oliveira, 2015 was recorded parasitizing, for the first time, a female spider of Leucauge henryi Mello-Leitão, 1940 in the Amazon rainforest, Brazil. Images, description of the cocoon and comments about this interaction were added.

First record of Hymenoepimecis manauara parasitizing Leucauge henryi with description of cocoon and comments about this interaction.
Tableaux and Systèmes. Early French Contributions to Linear Production Models
Authors: van den Berg Richard , Steenge Albert
Published: December 2016

L’histoire des modèles linéaires de production commence véritablement à partir de la seconde moitié du XVIII ème siècle. Une comparaison entre les Tableaux Economiques de François Quesnay et les Systèmes de Richesses d’Achilles-Nicolas Isnard permet de comprendre les différentes perspectives de cette branche naissante de l’analyse économique. Quesnay présente un modèle idéalisé de l’économie française, en faisant un certain nombre de présupposés contraignants, pour étudier la croissance et le déclin économiques. L’analyse d’Isnard est plus abstraite et générale, et se concentre sur les relations entre reproduction, prix et répartition. Les limites conceptuelles de leurs travaux, comme le présupposé implicite de prix constants pour Quesnay ou l’absence de règle pour la répartition du surproduit pour Isnard ont été retrouvées plus tard et résolues, de manière différentes, par des théoriciens postérieurs tels que Leontief, von Neumann et Straffa.
Richard Stone’s Contribution to Input-Output Analysis
Authors: Marangoni GianDemetrio , Rossignoli Domenico
Published: December 2016

Cet article met en évidence la contribution remarquable et originale de Richard Stone à l’analyse input-output, étroitement liée à sa carrière nationale et internationale. Son apport principal est d’avoir contribué au développement d’une normalisation internationale des comptabilités nationales et élaboré un modèle économétrique de croissance à la fois réaliste et général. Nous proposons une synthèse des deux principales contributions théoriques et empiriques de Stone à l’analyse input-output, et aussi d’autres essais moins connus. Parmi les premiers, on peut mentionner les études de Stone sur l’intégration des tableaux d’input-output dans le système des comptes sociaux nationaux (« SNA »), ses recherches sur les matrices de comptabilité sociale (« SAM »), la détermination et la mise à jour des coefficients techniques (méthode « RAS »). En ce qui concerne les travaux moins connus, on peut mentionner la tentative d’appliquer la méthodologie input-output au niveau microéconomique. Cet article montre enfin l’intérêt plus tardif de Stone pour l’application de l’analyse input-output à la démographie, la santé, l’éducation et l’environnement.
Les IME : qui sont-ils ? Où vont-ils ?
Authors: Marabet Bénédicte
Published: December 2016

Plus de 1 200 ime fonctionnent en France avec près de 70 000 places. La moyenne d’âge des jeunes accueillis est en augmentation constante, 7 % sont sous amendement Creton. Pour 60 %, au moins deux déficiences sont identifiées, ce qui témoigne de la diversité et de la complexité des situations. Près de la moitié ont des troubles du psychisme. Pour 16 %, autisme/ ted sont diagnostiqués – ces troubles sont de plus en plus fréquents. Les ime sont confrontés à plusieurs défis : l’adaptation de leur offre à des publics en évolution, le maintien de la qualité de l’accueil dans un contexte budgétaire contraint, l’accompagnement du passage vers la vie adulte.
Accompagnement des familles dont un membre présente une situation de handicap
Authors: Peille Françoise
Published: December 2016

La présence d’un membre en situation de handicap dans une famille pose la délicate question de l’aide à apporter à toute la famille et plus spécialement aux proches accompagnants. Cela met en jeu la problématique de la perte et du deuil, de la relation entre les accompagnants et leur enfant dans leur parentalité et de la réorganisation de chacun dans son économie psychique. Les modalités d’aide aux parents doivent tenir compte de la dynamique psychique mise en branle par l’arrivée de cet enfant porteur d’une différence dans leur histoire personnelle, de leur fragilité narcissique, de la place particulière de cet enfant dans leur investissement, sans oublier la culpabilité inhérente à cette situation.
Inclusion sociale et déficience intellectuelle : où en est le Québec ?
Authors: Bellefeuille Éric , Labbé Louise
Published: December 2016

Comment le Québec est-il passé des grandes institutions psychiatriques où étaient enfermées, il y a une quarantaine d’années, les personnes présentant une déficience intellectuelle à l’éclosion de tout un réseau varié permettant leur inclusion sociale ? Cet article relate le développement historique des pratiques, les choix sociopolitiques et les savoirs émergents qui permettent aujourd’hui d’envisager, avec beaucoup d’optimisme, la possibilité d’une véritable participation citoyenne pour ces personnes souvent plus vulnérables mais désormais membres à part entière de la collectivité.
« L’enfant-dossier » : une répétition perverse
Authors: Aubourdy Florence
Published: December 2016

Dans un contexte de mutations et de crises, l’évaluation, nouvelle égérie technico-scientifique, dessine la figure de l’imposture scolaire actuelle par la fabrique d’un regard pervers et une logique d’« enfant-dossier ». Cette déshumanisation qui imprègne les pratiques pédagogiques génère une violence symbolique, physique et morale sur un nombre de plus en plus important d’élèves. Cette impasse du désir menace les structures symboliques et la construction même de la pensée.
Appréhender le rapport à la mort de la personne psychotique dans le cadre d’un accompagnement
Authors: Gaillard-Bosson Michèle
Published: December 2016

Le rapport à la mort de la personne psychotique est en lien avec la psychose elle-même, maladie grave mettant la personne dans un état de mort psychique. L’angoisse de la personne est relative à la notion d’intégrité personnelle. Elle n’est pas sans conséquences possibles sur le vécu de l’accompagnateur : relation de type fusionnel, solitude professionnelle, paralysie de la pensée, disparition des limites, vécu d’impuissance, difficulté de séparation, violence psychique. Ces éléments nous amènent à conclure à l’importance de faire circuler la parole en équipe et d’élaborer les situations.
Utopies et TRANS-formation. Utopiens et utopiennes en mouvement. Introduction
Authors: Petitat André
Published: December 2016

Ce dossier s’inscrit parmi les différents hommages rendus à l’ Utopia de Thomas More à l’occasion du 500 e  anniversaire de sa publication. Il propose d’analyser, d’un point de vue sociologique, quelques propositions actuelles concernant l’éducation qui privilégient souvent l’éducation diffuse aux dépens des formes scolaires. À côté de l’enseignement formel, toutes sortes de relations –familiales, entre pairs, amoureuses et amicales, de travail domestique ou salarié, syndicales, coopératives, associations religieuses ou laïques, politiques, sportives, musicales, etc.– entraînent l’acquisition de connaissances et l’inculcation de valeurs. Dans cette galaxie de relations, les acteurs apprennent les tensions entre conformité et écarts et font l’expérience d’une dynamique, au cœur du fonctionnement social : la trans-formation concernant autant les savoirs que les valeurs et les engagements liés à un projet de dépassement du monde tel qu’il est. Le dossier rend plus compte de l’expérience des utopiens et utopiennes que des doctrines. Il décrit les liens entre des utopies en évolution et leurs acteurs en autotransformation (féministes, écologistes, néo-ruraux, communistes désenchantés, anciens combattants de la Première Guerre mondiale, fouriéristes français). L’incertitude de l’avènement d’un projet utopique renvoie ceux qui le portent à leurs capacités militantes : s’il n’y a pas de déterminisme historique allant dans le sens de l’utopie, l’espoir repose sur l’engagement volontariste. Dans certains cas, l’utopien-accoucheur se conçoit comme un instrument de l’histoire, une avant-garde éclairée ; dans d’autres, comme un inventeur imaginatif, engagé dans une construction sociale alternative. Dans tous les cas, l’engagement peut déboucher sur des conflits, des exclusions, des schismes, voire des violences.
Territorialisation, engagement des enseignants ruraux et rapports sociaux de sexe. Étude comparative entre le Chili, la France et l’Uruguay
Authors: Combaz Gilles , Rothenburger Catherine
Published: December 2016

Cet article vise à apporter quelques éléments de réponse à des questions concernant le poids du territoire et des rapports sociaux de sexe sur l’engagement des enseignants et leurs pratiques. Puis, réciproquement, sur l’inflexion que l’engagement d’enseignants intervenant dans des écoles rurales peut entraîner sur les rapports sociaux de sexe caractérisant le fonctionnement de certaines communautés villageoises observé au Chili, en France et en Uruguay. L’implication de ces enseignants dans des activités collaboratives –qui se situent en dehors de leur strict cadre professionnel– peut-elle contribuer au processus d’émancipation des femmes subissant la domination des hommes ? Peut-on mettre en évidence des formes d’engagement différentes chez les enseignants et les enseignantes ? Une observation ethnographique longue et quarante-deux entretiens approfondis permettent d’approcher ces interrogations.
Mémoire, fiction auctoriale et construction de l’autorité : l’exemple de la Deuxième lettre de Pierre
Authors: Butticaz Simon
Published: December 2016

La mémoire est une grandeur régulièrement mobilisée dans la littérature pseudépigraphe du Nouveau Testament. Jean-Daniel Kaestli l’avait souligné dans une étude de 1993 désormais classique. Depuis lors, les biblistes ont néanmoins perçu le caractère heuristique des travaux conduits en sciences humaines et sociales sur la « mémoire collective » par Halbwachs et Assmann et en ont progressivement appliqué les théories et les méthodes à l’étude du christianisme des origines. Simon Butticaz * en prolonge ici l’analyse, souhaitant montrer à l’appui de la Deuxième épître de Pierre, non seulement la manière dont est construite par le discours une mémoire apostolique dans la première moitié du ii e siècle, mais également sa fonction argumentative dans un contexte de communication troublé, ainsi que son rapport face à d’autres mémoires concurrentes des origines.
Les configurations de l’espace, du temps et de la subjectivité dans un contexte de terreur : l’exemple colombien
Authors: Pécaut Daniel
Published: December 2016

La terreur règne désormais dans nombre de régions colombiennes et les déplacements forcés en sont l’une des manifestations. Il s’agit ici d’analyser l’expérience même de la terreur chez ceux qui la subissent. À travers des notions comme celles de dé-térritorialisation, dé-temporalisation, dé-subjectivation, on prétend montrer l’impossibilité d’inscrire l’expérience dans un récit collectif qui lui donnerait sens et, au-delà, les spécificités de ce qu’on appelle la « violence ».
Mexique : La guerre contre le narcotrafic
Authors: Bataillon Gilles
Published: December 2016

Que penser de la lutte contre le narcotrafic engagée au Mexique début 2007 ? Pourquoi le Président de la république, Felipe Calderon, s’est-il engagé dans ce qu’il a lui-même baptisé une « guerre » contre le crime organisé ? Les actions entreprises ont-elles été engagées rationnellement et ont-elles été efficaces au regard des objectifs préalablement fixés ? Peut-on enfin escompter des changements dans les politiques contre le crime organisé mises en œuvre par le nouveau Président de la République, autant de questions qui surgissent à la lecture de l’actualité mexicaine.
Violer la loi pour maintenir l’ordre
Authors: Favarel-Garrigues Gilles , Gayer Laurent
Published: December 2016

Le vigilantisme recouvre une gamme d’actions collectives, souvent violentes et généralement illégales, dont la vocation proclamée est de maintenir l’ordre et/ou d’exercer la justice, au nom de normes juridiques ou morales. À travers cette définition, il ne s’agit pas de figer ces pratiques sécuritaires dans un concept inamovible. Tout en dressant un état de la littérature et des débats autour des vigilantes , cette introduction au dossier thématique plaide plutôt pour une analyse dynamique de la participation « citoyenne » au maintien de l’ordre, attentive aux fluctuations du répertoire d’action des groupes considérés. Il s’agit également de dégager quelques pistes de recherche permettant de dépasser la dichotomie substitution/complémentarité dans le rapport aux forces de l’ordre. L’observation fine des pratiques doit notamment permettre de voir comment ces groupes exercent des missions de police judiciaire et des formes d’auto-justice.
Des agents de l’État interchangeables ?
Authors: Laurens Sylvain , Serre Delphine
Published: December 2016

L’idée d’un État recrutant dans différentes classes sociales et mettant à profit les représentations de classe de ses agents dans le travail administratif semble aujourd’hui disqualifiée d’emblée tant elle laisse de côté les niveaux d’intermédiation qui existent entre la pratique et les dispositions des agents : la contrainte des rôles administratifs, la plasticité limitée du droit, le poids de la formation par les écoles de la fonction publique et le filtre des concours. Cet article se propose de revenir sur cette question classique de sociologie de l’État et quelque peu délaissée. En s’inspirant de la sociologie du travail, il défend l’hypothèse que l’entrée dans un poste, au sein de l’État, va de pair avec l’exposition à un processus continu de socialisation qui transforme, valorise ou disqualifie certaines dispositions acquises antérieurement. En s’appuyant sur diverses enquêtes menées en science politique et en sociologie, il dégage plusieurs pistes de recherche permettant de saisir la façon dont le travail administratif sélectionne, oriente et favorise l’actualisation de dispositions acquises antérieurement.
Un dimanche, vers six heures, au soleil levant
Authors: Privat Jean-Marie
Published: December 2016

L'analyse ethnocritique de Madame Bovary tend à prouver que le réalisme culturel du roman se manifeste dans l'enchevêtrement des mesures du temps. On propose d'abord une rapide sociographie des objets techniques de mesure du temps (horloge, montre, pendule), suivie d'une ethnographie matérielle des pratiques qui prennent – explicitement ou non — le temps comme étalon de mesure (les almanachs, les saisons). L'écriture de la fiction témoigne de cosmologies hétérogènes, bricolées et langagièrement marquées. La dernière partie repose sur la micro-analyse de trois exemples où les temporalités et les corps se singularisent (temps analogique, temps mécanique), s'hybrident ou se défont (temps cyclique, folklorique et paysan, temps linéaire de la raison comptable libérale). La contribution se conclut sur une étude sémantique et stylistique des rêveries mythico-poétiques d'Emma — en quête d'un rythme à la démesure mortelle de ses désirs.
Le Vin de solitude d’Irène Némirovsky : journal de genèse
Authors: Viollet Catherine
Published: December 2016

Les manuscrits du Vin de solitude, « roman autobiographique » d’Irène Némirovsky, éclairent surtout sur les intentions de l’auteur, et offrent l’occasion de suivre les procédés qui permettent à l’écrivain de passer de l’ordre du référentiel à celui de la fiction, à partir du travail de (re)mémoration des souvenirs de sa vie d’enfant et de jeune fille prise dans la tourmente de la révolution russe. D’autre part, ébauches et brouillons se trouvent être à la fois journal de travail et avant-texte de l’œuvre, les deux types de discours restant intimement associés.
L’Assommoir et Mon voisin Jacques d’Émile Zola : étude comparée de la genèse des personnages secondaires
Authors: Nakamura Midori
Published: December 2016

Les personnages de second plan sont parfois eux aussi investis de fonctions spécifiques au récit. Une enquête sur la genèse des personnages de L’Assommoir (1877) d’Émile Zola nous permet de trouver les traces de la programmation. Dans l’Ébauche de ce roman, le croque-mort Bazouge, annonciateur de la mort de l’héroïne, est aussi un ouvrier incarnant la machine humaine usée par le travail et la misère. Mais la cohabitation des figures de croque-mort et d’ouvrier semble difficile, Zola crée donc deux personnages et renomme l’ouvrier « Bru » pour donner à Bazouge l’autre rôle. L’origine de ces deux personnages se trouve dans le conte Mon voisin Jacques, que Zola n’a cessé de récrire (1865-1874). Le caractère ambivalent du protagoniste de ce conte, le croque-mort Jacques, sera réparti sur deux personnages secondaires dans le roman postérieur : Bazouge héritera du côté sinistre pour incarner la Mort et Bru du côté bonhomme pour se charger de la figure du mortel. La multiplication des personnages et la simplification de leur caractère sont en rapport étroit avec les procédés d’élaboration propres au genre romanesque.
A NOVEL SIGNAL-BASED FUSION APPROACH FOR ACCURATE MUSIC EMOTION RECOGNITION
Authors: Goshvarpour Atefeh , Abbasi Ataollah , Goshvarpour Ateke , Daneshvar Sabalan
Published: December 2016

The objective of this study is to propose an accurate emotion recognition methodology. To this end, a novel fusion framework based on wavelet transform (WT), and matching pursuit (MP) algorithm was offered. Electrocardiogram (ECG) and galvanic skin response (GSR) of 11 healthy students were collected while subjects listened to emotional music clips. In both fusion techniques, Coiflet wavelet (Coif5 at level 14) was chosen as a wavelet family and MP dictionary, respectively. After employing the proposed fusion framework, some statistical measures were extracted. To describe emotions, three schemes were adopted: two-dimensional model (five classes), valence-(three classes), and arousal-(three classes) based emotion categories. Subsequently, the probabilistic neural network (PNN) was applied to classify affective states. The experiments indicate that the MP-based fusion approach outperform the wavelet-based fusion technique or methods using only ECG or GSR indices. Considering the proposed fusion techniques, the maximum classification rate of 99.64% and 92.31% was reached for the fusion methodology based on the MP algorithm (five classes of emotion) and wavelet-based fusion technique (three classes of valence), respectively.
DETECTING AND ANALYZING COPY NUMBER ALTERNATIONS IN ARRAY-BASED CGH DATA
Authors: Sheha Mariam A. , Mabrouk Mai S. , Elhefnawi Mahmoud
Published: December 2016

Copy number changes or alterations are a form of genetic variation in the human genome. Genomic DNA copy number alterations (CNAs) are associated with the development and progression of cancers. Array-based comparative genomic hybridization (a-CGH) is a technique used to identify copy number changes in genomic DNA. It yields data consisting of fluorescence intensity ratios of test and reference DNA samples. The intensity ratios provide information about the number of copies in DNA. Practical issues such as the contamination of tumor cells in tissue specimens and normalization errors necessitate the use of automated statistics algorithms for learning about the genomic alterations from array CGH data. Specifically, there is a need for algorithms that can identify gains and losses in the number of copies based on statistical considerations, rather than merely detect trends in the data. For this purpose the proposed study introduces three different approaches; Circular binary segmentation, Bayesian approach, relying on the hidden Markov model and effective Gaussian mixture (GM) clustering for the analysis of array CGH profiles. Publicly available data on pancreatic adenocarcinoma and Coriell cell line bacterial artificial chromosome (BAC) array were used for the analysis to illustrate the reliability and success of the techniques.
DEVELOPMENT OF UTERINE CONTRACTION MONITORING SYSTEM FOR RESOURCE-LIMITED SETTINGS
Authors: Degbedzui Derek Kweku , Mills Godfrey A. , Kaufmann Elsie Effah
Published: December 2016

A need assessment exercise at various resource-limited hospitals in Ghana revealed that a conventional method of monitoring uterine contractions is employed. This method is time consuming and ineffective with a likelihood of misrepresenting data on uterine contractions. There is therefore a need for a system that can potentially overcome the identified challenges. In this paper, the authors present the proof of concept for development of an automated uterine contraction monitoring system designed for use in resource-limited settings. Following the engineering design process, data were gathered to draft product specifications. Various concepts were evaluated and a mathematical model of chosen concept was built and simulated. A functional prototype was constructed to test the system’s ability to measure the frequency and average duration of muscle contractions over a specified interval. The results indicate the capability of the chosen concept to meet design specifications. The design can also be enhanced to provide the intensity of contractions.