bluuebunny/crossref_metadata_2025 huggingface dataset:
A simple orthonormalization method for stable and efficient computation of Green's functions
Authors: Wang Rongjiang
Published: November 2022

Some major matrix methods for computation of Green's functions of a layered half-space model are compared. It is known that the original Thomson-Haskell propagator algorithm has the loss-of-precision problem when waves become evanescent. The minor matrix extension solves to some extent the numerical problem but at the expense of the computational efficiency. At present, the recursive technique (the reflectivity method) is used by most seismologists. An alternative algorithm is presented that uses the same strategy as the original propagator algorithm but avoids the numerical problem by inserting an additional numerical procedure into the matrix propagation loop. The new technique is simple and efficient, and in particular, it is not only applicable to the matrix method but also to any numerical integration method for general use. High-frequency synthetic seismograms are computed for modeling significant site effects such as observed in the aftershocks of the Latur earthquake, 1993, India.
A point pattern analysis of the distribution of earthquakes in Normandy (France)
Authors: Amorese D. , Lagarde J.-L. , Laville E.
Published: November 2022

A new mathematical method has been developed to guide the interpretation of sparse epicenter distributions. The aim of the technique is the assessment of the significance of epicenter alignments. This assessment is connected to the detection of seismic faults. The method has been tested on synthetic data sets and on seismicity from the San Francisco Bay area. These tests show high detection capabilities. When the method is applied to actual data, in order to discard artificial lines, the interpreter must check the results using geological information. The method is applied to epicenters in Western Normandy: The main structural directions of Normandy are tracked by sparse epicenters.
Identification of astrocyte subtypes in the Drosophila melanogaster visual system
Authors:   , Saunders Jillian Clare , von Reyn Catherine R. , Garcia Anna Denise R.
Published: November 2022

Astrocytes are the most abundant glia cell type and regulate synapse formation, maturation, and function. Though often studied as a single population, astrocytes are now recognized as encompassing a heterogeneous population. However, the genetic signatures and functional properties of distinct astrocyte populations remain poorly understood. Drosophila melanogaster is a good model for studying astrocytes on this level due to many available genetic tools and conserved astrocyte properties. Here, we establish a bioinformatics and quantitative immunohistochemistry pipeline to investigate heterogeneity within Drosophila astrocytes. We identify three genetic markers to classify astrocytes among unlabeled glia clusters in sc-RNAseq datasets from the Drosophila visual system. These markers alrm, Eaat1, and Gat separate astrocytes among various glial populations during pupal development but only Eaat1 and Gat reliably label astrocytes during adulthood. Using these markers, we identify two astrocyte clusters in both datasets and find these clusters have the highest correlations when comparing their genetic profiles. To validate these predictions, we first identify the transgenic line GMR86E01-Gal4 as a more effective line for labeling astrocytes of the adult fly than the commonly used alrm- Gal4. Antibody labeling of Eaat1 and Gat shows high colocalization to GMR86E01-Gal4, validating the use of these markers to identify astrocytes. We then sought to identify genetic differences between the predicted astrocyte clusters. A differential gene analysis identified 3 genes that are differentially expressed between predicted astrocyte pupal clusters and 30 genes differentially expressed between predicted adult astrocyte clusters. Overall, this work provides insights for identifying genetic signatures in astrocyte subtypes.
ChMedical Care of Infants with Down Syndrome in Sub-Sahara Africa; Challenges and the Way Forwardallenges In Managing Children With Down Syndrome In Sub-Saharan Africa; And The Way Forward
Authors: Elshazali O , Abdullahi H
Published: November 2022

Down syndrome is the most common chromosomal malformation, it affects multiple organs, necessitating a need for medical care for different systems. The care needed by infants with Down syndrome is complex and needs planning and coordination at different levels. Medical services in Sub-Saharan Africa are not robust and face challenges in providing accessible and affordable health care. We will review the situation of the medical care provided to infants with Down Syndrome, looking at diagnosis, counselling, and management within the Sub-Saharan context. Exploring the challenges and suggesting recommendations.
Intestinal Lymphedema and Structural Changes in Crohn's Disease
Authors: Tonelli Pietro
Published: November 2022

Background and Aims: In 1954 Warren and Sommers asserted that Crohn’s disease was “essentially an elephantiasis of the intestinal wall”. They described a late phase of Crohn’s disease and did not try to reconstruct the various stages of the disease. The aim of this study is to provide a step-by-step reconstruction of the anatomic changes that lead to “terminal ileitis”, i.e., to define the pathologic process. Methods: A pathologic examination of over 100 surgical specimens of Crohn’s disease was performed. Findings were compared with those of the published literature in order to derive sequential stages in disease evolution. Results: Terminal ileitis occurs in four different steps. The initial event is thought to be the obstruction of the ileal branch of the superior mesenteric lymphatic collector. It leads to progressive lymphatic stasis and lymphangiectasias of all the layers of lymphatics of the intestinal wall, i.e. an intestinal lymphedema (Step 1). Progressive accumulations of protein-rich lymph occur in intestinal wall, that in the mucosa result in aphthous ulcers. The increase in pressure in the intestinal lymphatic network causes rupture of superficial lymphangiectasias (Step 2). These early parietal changes allow bacterial contamination of the lymphedema which, over time, leads to chronic superficial enteritis and granulomatous lymphangitis (Step 3). Finally, fibrosis is reached (Step 4). Conclusions: Crohn’s disease is a lymphedema of the intestinal wall contaminated by intestinal contents, ending in fibrosis. The structural changes defy therapeutic resolution. Keywords: Crohn’s disease, lymphedema, lymphatics
Is Covid vaccine(Covishield) giving rise to de novo cutaneous autoimmune disorders and aggravating the existing ones –a case series of 10 patients with review of literature.
Authors: Garg Suruchi , Tuknayat Ankita , Hans Titiksha
Published: November 2022

Covid-19 which is an ongoing pandemic, has already caused millions of deaths and disabilities till date. Covid scenario and mass vaccination has completely changed the understanding of dermatological disorders. The clinicians are noticing a sudden increase in new onset autoimmune disorders and aggravation of existing ones. The study is based on 3 hypotheses i.e. antibody dependent enhancement of virus, molecular mimicry and antigen antibody complex formation, explaining the pathogenesis involved in vaccine induced cutaneous autoimmune disorders. METHODS In this prospective observational study, we observed 2 groups of patients following Covishield vaccine-Group 1: appearance of new lesions pertaining to autoimmune disorders Group 2: exacerbation of cutaneous lesions of already existing autoimmune disorder The diagnosis was made based on appearance of clinical signs within 6 weeks of vaccination dose and the clinical diagnosis was established by at least two Dermatologists. RESULTS Ten patients were enrolled in this study over a period of 6 months. Six patients (Group 1) presented with new onset of lesions whereas 4 patients (group 2) presented with exacerbation of existing autoimmune disease. Patients were given medical treatment as per disease severity along with proper nutritional support and antioxidants. CONCLUSION This article highlights the importance of creating awareness and staying vigilant for the appearance of any new autoimmune disease and exacerbation of existing disorder and for future course of action for choice of vaccination and booster doses. A chronological association in last 6 weeks of vaccination dosage must be evaluated in detail and causative association should be considered in autoimmune disorders.
Climate Change Mitigation Policies: Aggregate and Distributional Effects
Authors: Cavalcanti Tiago , Hasna Zenia , Santos Cezar
Published: November 2022

We evaluate the aggregate and distributional effects of climate change mitigation policies using a multi-sector equilibrium model with intersectoral input-output linkages and worker heterogeneity calibrated to different countries. The introduction of carbon taxes leads to changes in relative prices and inputs reallocation, including labor. For the United States, reaching its original Paris Agreement pledge would imply at most a 0.8% drop in output. This impact is distributed asymmetrically across sectors and individuals. Workers with a comparative advantage in dirty energy sectors who do not reallocate suffer a welfare loss at least six times larger than workers in other sectors, but constitute less than 2% of the US labor force.
Enseignement immerserif des langues étrangères au moyen des technologies virtuelles
Authors: Duée Claude , Martin Justine
Published: November 2022

Las tecnologías están en constante evolución y la democratización de los vídeo juegos, de los sistemas de realidad virtual, realidad aumentada o de las herramientas de vídeos interactivos cuestionan nuestras prácticas de enseñanza y nos llevan a reconsiderar la forma de concebir experiencias inmersivas en lenguas extranjeras. Hoy, la inmersión cultural o lingüística en el aula es posible gracias al uso de tecnologías inmersivas e interactivas que permiten estimular el aprendizaje y la motivación del alumnado. Esta obra presenta proyectos realizados en aulas de idiomas y hace un análisis de la situación, de conceptos claves y de algunas estas tecnologías.
Regularities of Сhlorine Distribution During Thermal Disposal of Chlorine-Containing Medical Waste
Authors: Dvoskin G.I. , Kornileva V.F. , Starnikov M.A. , Pudova Ya.D. , Gerasimov G.Ya.
Published: November 2022

The results of an experimental study of the regularities of the distribution of chlorine between solid and gaseous products during the thermal decomposition of a mixture of chlorine-containing medical waste during their pyrolysis and incineration are presented. It is shown that under thermal action on the chlorine-containing components of the mixture, chlorine is partially converted into gaseous products in the form of Hcl, and partially retained by the coke-ash residue. During pyrolysis, the bulk of chlorine remains in the solid phase. It is concluded that the retention of a significant proportion of chlorine by solid products of thermal decomposition significantly reduces the possibility of dioxin synthesis at the stage of flue gas cooling due to the low content of free chlorine in them.
Lithogenic Potential of Soils Formation in Technogenic Landscapes of Siberia
Authors: Sokolov D.A. , Gurkova E.A. , Sokolova N.A.
Published: November 2022

The results of long term research on the influence of rocks stored in dumps during coal mining on the rate of soil processes during the regeneration of technogenic landscapes are presented. An approach to assess the lithogenic potential of soil formation as an integral indicator of the ability of technogenic substrates to ensure the formation of a climate-appropriate soil profile was developed and applied. It is shown that the main properties forming the potential are the density, rockiness and texture of rocks. The rockiness decreases in the upper part of the profile and the manifestation of signs of an eluvial process and the formation of a finely dispersed fraction during biochemical weathering was noted. The dependence of the processes of profile differentiation on the properties of the substrate and on hydrothermal conditions has been revealed. It is shown that the optimal conditions for the developing of the substrate by soil processes are formed on the dumps of coal and brown coal deposits in a humid climate. Further development of soil-forming processes limits by the increase in climate aridity and the degree of rock metamorphism.
Bottom Sediments as an Indicator of the Geoecological State of Natural Water Currents
Authors: Legostaeva Ya.B. , Gololobova A.G.
Published: November 2022

The parameters of the natural geochemical background of ecosystems of the Lunnoye deposit area were studied and the geoecological conditions of large and small watercourses of the Yukhukhta — Yukungra interfluve were assessed according to the state of the total pollution index of bottom sediments. 27 elements of the gross content were determined by the method of emission spectral analysis. The elements that determine the geochemical specificity of the territory were revealed: Bi, Li, Sn, Y, Be, Sc, K, Th, Cs and Ra. At the time of research, the state of the surface watercourses of the territory is assessed as moderately polluted. With further monitoring, special attention should be paid to the state of the river basin Yukhukhta and especially the dynamics of changes in the chemical composition of bottom sediments of the brook. Lunny and Mramorny. The elements K, Th, Cs, Ra, Be, Zn, Pb, As, Cr, and Ni are proposed as parameters for monitoring the geoecological state of bottom sediments.
Comparative Analysis of Temperature Distributions in a Convective-Radiative Porous Fin using Homotopy Perturbation and Differential Transformation and Methods
Authors: Sobamowo Gbeminiyi Musibau , Oladosu Suraju Aremu , Kuku Rafiu Olalekan , Siqueira Antonio Marcos de Oliveira
Published: November 2022

In this work, a comparative study of two approximate analytical methods for the thermal behaviour of convective-radiative porous fin subjected to the magnetic field using homotopy perturbation and differential transform methods is presented. Also, parametric studies of the effects of thermal-geometric and thermo-physical fin parameters are investigated. From the study, it is found that an increase in a magnetic field, porosity, convective, radiative, and parameters increase the rate of heat transfer from the fin and consequently improves the efficiency of the fin. There are good agreements between the results of the homotopy perturbation and differential transform method with the results of the numerical method. Also, the results of the two approximate analytical methods agree very well with each other. It is hoped that the present work will serve as the basis of verifications of the other works on the nonlinear thermal analysis of the extended surface.
A heteronormatividade e a saúde de mulheres bissexuais e lésbicas universitárias
Authors: Regner da Silva Naiara , Soares Mota Marina , Hatje Luís Felipe , Rocha Gutmann Victoria Leslyê , Coutinho Costa Vallejos Carolina , Silva Camila Daiane
Published: November 2022

Objetivo: conhecer a percepção de mulheres bissexuais e lésbicas universitárias sobre a heteronormatividade e sua influência na saúde. Método: estudo descritivo, quali-quantitativo, realizado no primeiro trimestre de 2020, com mulheres bissexuais e lésbicas acadêmicas de graduação e/ou pós-graduação por meio de questionário online. Os dados foram tratados pela Análise de Conteúdo e estatística descritiva. Resultados: participaram 163 mulheres, das quais 110 se declararam bissexuais e 53 lésbicas, das quais 140 eram discentes da graduação, idade entre 18 e 29 anos (93,87%), 57% informavam a orientação sexual nos atendimentos em saúde e 28,83% não informavam. Nas percepções a heteronormatividade influência na saúde em 73,62%. Duas categorias foram construídas: “A percepção da heteronormatividade e as implicações culturais, sociais e políticas de saúde” e “A heteronormatividade e as implicações pessoais em saúde”. Pela heteronormatividade tem-se: danos à saúde, mental ou física; orientação sexual invisibilizada; falta de campanhas publicitárias e conhecimento insuficiente dos profissionais de saúde, inclusive sobre as sexualmente transmissíveis. Conclusão: atuar mais sobre a saúde de mulheres lésbicas e bissexuais é importante tanto em termos de políticas públicas, como num maior preparo dos profissionais envolvidos.
Tendencias y desafíos en investigación formativa de la seguridad operacional en la Fuerza Aérea Colombiana
Authors: Ramírez Segura Bryan Felipe , Ariza Ariza Leidy Gabriela , Pava Juan David
Published: November 2022

El artículo pretende realizar un análisis del estado actual de la investigación formativa generada en la Maestría en Seguridad Operacional (Maeso) de la Escuela de Posgrados de la Fuerza Aérea Colombiana (EPFAC), con la intención de visualizar los productos académicos y la proyección de los resultados de aprendizaje en el programa desde sus inicios. De igual forma, se busca explicar los elementos que presentan los intereses de los estudiantes y las líneas de investigación actuales, a fin de establecer desafíos en la formación de profesionales especializados. Así mismo, se busca reconocer fortalezas y necesidades de indagación, problemáticas de interés y áreas de estudio que permitan robustecer el campo de estudio de la seguridad operacional en Colombia. Entre los resultados encontrados se interpreta el análisis sociocrítico de las problemáticas del contexto aeronáutico desde la seguridad operacional, y el interés de responder al campo de investigación a partir de investigaciones cualitativas con productos consolidados como programas, protocolos o guías. Se encontró que la mayoría de los trabajos son programas que pretenden prevenir, mitigar y administrar la seguridad operacional en la aviación civil y militar. La línea de investigación de factores humanos ha sido la más amplia fundamentada en su impacto directo en los cargos que ocupan los estudiantes, pero le sigue la gestión de la seguridad operacional con los trabajos que se vienen desarrollando.
Ideology, Politics and Society in Antonio Gramsci's Theory of Hegemony
Authors: Leśniak Tomasz
Published: November 2022

In this article, I examine Antonio Gramsci's theory of hegemony by situating it in relation to a more general intellectual and socio-political context involving orthodox Marxism, October Revolution and Italian fascism. I first briefly outline the problem of economism in Marxist theory, as it is the main object of Gramsci's critique developed fully in the Prison Notebooks. The next two sections are devoted to October Revolution and Italian fascism, interpreted as two elements of the socio-political conjuncture which called into question Marx's 'base/superstructure' model of society and its mechanistic rearticulation. Finally, I discuss Gramsci's  mature political theory as an attempt to break with economic determinism and class reductionism of classical and orthodox Marxist theory. I argue that his original conception of hegemony constitutes an advance towards a non-essentialist and relational conception of politics and society.
INTERRELATION BETWEEN MITOCHONDRIAL ENZYME ACTIVITY AND ANTIOXIDANT ACTIVITY OF SECONDARY POLYPHENOL NATURE METABOLITES IN HEMIPARASITE VISCUM ALBUM L. LEAVES
Authors: Adzhiakhmetova S. L. , Pozdnyakov D. I. , Chervonnaya N. M. , Kulichenko E. O. , Oganesyan E. T.
Published: November 2022

Antioxidants are widely used in practical medicine. Not only the search for new plant antioxidants, but also the study of the factors affecting their accumulation in plants, are relevant.

The aim is to study the interrelation between the activity of mitochondrial enzymes and the antioxidant activity of the secondary polyphenolic nature metabolites in hemiparasite Viscum Album L. leaves.

Materials and methods. The sampling material was Viscum album L. leaves, collected in winter from a host tree, Malus domestica Borkh. The extraction of biologically active substances was carried out with ethyl alcohol of various concentrations (90%, 70% and 50%), or purified water. The amount of total antioxidants was estimated by the amperometric method. The amount of total phenols was evaluated in the reaction with the Folin-Ciocalteu reagent. The concentration of total flavonoids was estimated by the change in the optical density of the rutin with aluminum (III) chloride complex. The antioxidant properties of the analyzed extracts were determined in vitro in the induced lipid peroxidation test. The activity of aconitase was assessed by a conjugated aconitase-isocitrate dehydrogenase reaction, citrate synthase – by changing the color intensity of the Ellman reagent solution, succinate dehydrogenase were determined in the reaction of succinate-dependent oxidation of 2,6-dichlorophenolindophenol.

Results. The carried out study showed that the maximum amount of total phenols (2.39±0.05%) is observed in a 50% ethanol extract from Viscum album L. leaves, with the content of total flavonoids equal to 1.83±0.04%, and the antioxidants equal to 0.503±0.007 mg/g (a quercetin equivalent) and 0.322±0.006 mg/g (a gallic acid equivalent). A 50% ethanol extract suppressed lipid peroxidation in the model mixture with IC50=106.3±1.09 µg/ml. In Viscum album L. leaves, a high activity of aconitase which strongly correlated (r=0.88416) with changes in the concentration of flavonoids, has been notified.

Conclusion. The optimal extractant for obtaining extracts with a high antioxidant activity is 50% ethyl alcohol. The analysis of the mitochondrial enzymes activity showed that in Viscum album L. leaves collected in winter, a high activity of aconitase strongly correlated with changes in the concentration of flavonoids (r=0.88416).
CORRIGENDUM: “EVALUATION OF WEIGHT REDUCTION EFFICACY AND SAFETY OF SIBUTRAMIN-CONTAINING DRUGS IN PATIENTS WITH ALIMENTARY OBESITY”
Authors: Demidova T. Yu. , Izmailova M. Ya. , Ushakova S. E. , Zaslavskaya K. Ya. , Odegova A. A. , Popova V. V. , Nevretdinova M. E. , Bely P. A.
Published: November 2022

In the published article “Evaluation of weight reduction efficacy and safety of sibutramin-containing drugs inpatients with alimentary obesity”, there was an error in the author list. Due to a technical error on author’s part andwithout any malicious intent, the authors name A.F. Verbovoy, who was not directly involved in writing the articleand not made a great contribution to the work were added. The corrected author list appears below.T.Yu. Demidova, M.Ya. Izmailova, S.E. Ushakova, K.Ya. Zaslavskaya, A.A. Odegova,V.V. Popova, M.E. Nevretdinova, P.A. BelyThe error does not change the essence of the data presented in the article, does not violate their perception byreaders or interpretation.Authors confirm the accuracy of the information provided in this letter about the composition of the team ofauthors, and that the contribution of each author complies with the recommendations of the ICMJE. The originalarticle has been updated.
A Naszály lepkéi (Lepidoptera) II.
Authors: Szabóky Csaba , Szabadfalvi András , Pintér Balázs
Published: November 2022

Több mint tíz év telt el a Naszály lepkéit tárgyaló első közlemény megjelenése óta. Ismert tény, hogy a faunisztikai kutatást sohasem lehet lezártnak tekinteni, mert időről időre újabb fajok jelennek meg a vizsgált területen. A területről ebben az elmúlt időszakban 51 új moly- és 75 új nagylepkefaj került elő, összesítve 1473 lepkefaj vált ismeretessé (727, ill. 746 faj). A fajszám tekintetében a munka a hazai faunakutatás élvonalába tartozik. A lista 16 védett fajjal bővült, melyek a következők: Hemaris tityus, Aglia tau, Boloria euphrosyne, Euphydryas maturna, Neptis sappho, Nymphalis xanthomelas, Archiearis notha, Archiearis parthenias, Drymonia velitaris, Ocnogyna parasita, Cucullia chamomillae, Diachrysia zosimi, Euchalcia variabilis, Euxoa vitta, Rileyiana fovea, Scotochrosta pulla.
Aspectos clínicos y factores asociados al estrés postraumático en pacientes adultos de tres ciudades de la sierra peruana.
Authors: Contreras-Rodríguez Jimena , Quintana-Cadillo Angela , Yacchi-Sarmiento Ayko , Saavedra- Castillo Javier
Published: November 2022

El Trastorno por Estrés Postraumático (TEPT) es una condición psiquiátrica que surge como respuesta a eventos traumáticos y puede afectar significativamente la funcionalidad del paciente. La sierra andina es una región cuya población ha estado expuesta a eventos altamente estresantes; sin embargo, existe escasa información sobre factores asociados a la ocurrencia de TEPT en la región. Objetivo: Determinar los factores sociodemográficos y clínicos (comorbilidad y funcionalidad) asociados al TEPT. Material y métodos: Se trata de un estudio secundario que utilizó la base de datos del adulto del Estudio Epidemiológico de Salud Mental en la Sierra – 2017. Instrumentos: Mini Entrevista Neuropsiquiátrica Internacional (MINI) en la versión en español de CIE-10, Cuestionario de Salud Mental de Colombia, Escala de Discapacidad y una ficha de datos demográficos e indicadores de pobreza. Resultados: Se encontraron asociaciones significativas entre TEPT y grupos de personas casadas y carentes de instrucción escolarizada. El episodio depresivo fue la comorbilidad más frecuente. Los principales estresores fueron la violencia política y los accidentes graves. Asimismo, hubo asociación de TEPT con pensamientos suicidas y dificultad para planificar, organizar y ejecutar diversas actividades. Conclusiones: Existe asociación relevante entre TEPT y algunos factores sociodemográficos, eventos traumáticos y trastornos clínicos. Los programas de intervención deben brindar atención inmediata a personas expuestas a eventos traumáticos y disminuir la presencia y el impacto de factores estresantes presentes en la región andina.
Evidencias de validez del inventario de respuestas de afrontamiento al estrés durante el covid-19, para estudiantes universitarios de Chiclayo (Perú)
Authors: Arévalo Luna Edmundo , Ruiz Alva César , Gamarra Moncayo José
Published: November 2022

El presente es un estudio tecnológico de tipo instrumental, cuyo objetivo fue obtener evidencias iniciales de validez de una nueva versión del Inventario de Respuestas de Afrontamiento al Estrés, originalmente elaborado por Arévalo en el año 2008. Primero, se llevó a cabo la redefinición de las dimensiones evaluadas, así como también la reformulación y reducción del número de ítems. La validez de contenido se estableció mediante evaluación por jueces. Las siguientes etapas de este trabajo se realizaron en estudiantes universitarios de la ciudad de Chiclayo (Perú), con edades de 18 a 25 años. La adecuación lingüística fue evaluada en un primer grupo de 20 estudiantes. El análisis de la estructura interna y la confiabilidad se realizó en 200 estudiantes y el estudio de normalización en 800 estudiantes. Los valores del coeficiente V de Aiken fueron superiores a 0.80 para cada uno de los reactivos; así mismo, en el análisis ítem-test, se obtuvieron correlaciones por encima de 0.67. El análisis factorial exploratorio mediante componentes principales y rotación varimax estableció tres factores, las cargas de los ítems en dichos factores estuvieron, para el afrontamiento directo, entre 0.679 y 0.770; en el afrontamiento desadaptativo, entre 0.662 y 0.867 y en el afrontamiento defensivo, entre 0.614 y 0.790. La confiabilidad a través del método de las mitades y alfa de Cronbach, reportó valores por encima de 0.80 en cada uno de los factores. Estos resultados indican adecuadas propiedades psicométricas. Finalmente, se elaboró una norma interpretativa única para toda la muestra, ya que no se hallaron diferencias significativas entre las puntuaciones de hombres y mujeres.
Examining Learner Autonomy in EFL Learning of the Undergraduate Students
Authors: Arshad Ali Mohammad , Alam Alaul
Published: November 2022

The study examined the learner autonomy in EFL learning at the undergraduate level in the context of Bangladesh. It investigated the effectiveness of learner autonomy on EFL learning. Besides, it explored the factors affecting autonomous learning in English language class. This study adopted a mixed- method approach. Data were collected from 60 students who had just completed their second semester at a private university in Dhaka city. The respondent students attended the compulsory English foundation course including their two semesters. Data were also collected from 12 ELT teachers teaching at the tertiary education level. Five EFL classes were observed following a sample of classroom observation schedule. Both open-ended and closed-ended questionnaires were used by the researchers for collecting the data from the students and teachers. Major findings of the study showed that lack of confidence, teachers’ dependency, lack of motivation, short-term goals in learning, huge confusions and confinement in memorization, tendency of using mother tongue and unawareness to self-evaluation of students affected learner autonomy in EFL learning of the undergraduate students. However, the study revealed that motivated students hardly faced any difficulties in achieving maximum outcomes with autonomous learning in the EFL class. Finally, the researchers gave a number of recommendations to bring out effective EFL learning with learner autonomy.
Analysis of Public Services to Bureaucracy Changes in the Covid-19 Pandemic Era
Authors: Rohmat Aas , Elisanti Evi
Published: November 2022

The purpose of study is to analyze public services for employees in Covid-19 Pandemic Era. The research method used is descriptive research with a qualitative approach. This research was conducted at the Directorate of Cooperation, Development, and Internationalization at a University in Solo. Data collection was carried out by observation and documentation. The results shows public services in 2020 with 81 MoUs and 226 MoAs, increasing significantly compared with those 2019 with 79 MoUs, 208 MoAs, and those up to May 2021 with 30 MoUs and 106 MoAs. The number of recommendation/approval processes for the foreign official travel documents for Lecturers & Educators and Students decreases significantly for three consecutive years from 2019 to 2020. The changes in the Covid-19 Pandemic Era are aspects affecting the changes in institutions and work systems. Optimizing the cooperation service system, the Directorate of Cooperation, Development, and Internationalization has created an integrated cooperation information system. The work system in cooperation services changes from the manual or conventional face-to-face one before covid-19 pandemic into an electronic system based on online zoom, google meetings and so on with optimal use of communication technology so ideas are needed new quality and innovative ASN human resources in the pandemic era.
Plan de negocio para la venta de juego de vajillas hechas de bambú 100% natural biodegradable
Authors:   , Farfan Huaman Juan Carlos , Santiago Espinoza Nataly Sofia , Pretell Terrones Renato Alejandro , Gonzales Cahuaza Andy Junior , Ameri Felices Lisseth Lucero
Published: November 2022

El siguiente plan de negocio tiene como objetivo la venta de Vajillas hechas de bambú 100% biodegradable, para la zona de Lima Moderna. Hoy en la actualidad debemos tener los cuidados necesarios a la hora de alimentarnos, ya que son un tema de mucha importancia debido a los trastornos que sufrimos por los descuidos que tenemos, y también por la pandemia COVID -19 y otras enfermedades estomacales, ya que los utensilios que usamos podrían afectar el organismo de los humanos, nuestra demografía objetivo tiende a cuidar al momento de servir sus alimentos de un modo más saludable lo que mejora el estilo de vida, con la finalidad de proteger enfermedades y tener un sistema estomacal fuerte, saludable y poder contrarrestar cualquier infección o enfermedad. Es por ello, que creamos el plan de negocio para comercialización de Vajillas hechas con bambú guadua angustifolia 100% ecológicas, con el objetivo de mejorar los estilos de vida de todas las personas y convencer a la adecuada alimentación saludable. Por consiguiente, nuestro propósito es cumplir con los requerimientos de salubridad y es así como nace la idea de negocio “VIDA BAMBU” orientado al público femenino con edades de 25 a 55 años ubicadas en lima moderna, llegando así a ser nuestra oportunidad de negocio. Actualmente, el sector de vajillas ecológicas de bambú, se observa que está en gran crecimiento. Por ello, nuestra idea de negocio llegará a contribuir con el crecimiento del PBI y contribuir en la sociedad para que siga este estilo de vida activo, acelerado el cual no les permite alimentarse saludablemente.
Frecuencia de radix entomolaris y paramolaris en primeros molares permanentes inferiores mediante evaluación tomográfica de haz cónico
Authors:   , Oblitas Vidalon Marianella del Carmen
Published: November 2022

OBJETIVO: Determinar la frecuencia del Radix Entomolaris y Radix Paramolaris en primeros molares inferiores permanentes y su relación en cuanto a bilateralidad y sexo mediante tomografía computarizada de haz cónico en el Centro de Diagnóstico por Imágenes en Lima de Enero del 2010 a Diciembre del 2014. MATERIALES Y METODOS: Se trabajó en una muestra de 125 tomografías de pacientes mayores de 10 años de edad varones y mujeres que presenten los primeros molares permanentes inferiores de manera unilateral o bilateral, la técnica de recolección de datos fue la observación, nuestro instrumento fueron las tomografías computarizadas de haz cónico de los pacientes atendidos en el Centro de Diagnóstico por Imágenes de la ciudad de Lima (revisión documental). RESULTADOS: En las 125 tomografías de pacientes se hallaron 7 (6,3%) Radix Entomolaris ,4 (3,6%) en el lado derecho y 3 (2,7%) en el lado izquierdo. En las 125 tomografías evaluadas no se hallaron Radix Paramolaris. En relación a la variable sexo y bilateralidad no hubo diferencia significativa, encontrándose 2 (1.8%) Radix Entomolaris en varones en el lado derecho y 2 (1.8%) en el lado izquierdo. En mujeres, se hallaron 2 (1,8%) Radix Entomolaris en el lado derecho y 1 (0.9%) Radix Entomolaris en el lado izquierdo, y un solo caso de bilateralidad en el sexo masculino. CONCLUSIÓN: Se concluyó que el porcentaje de pacientes con Radix Entomolaris fue de 6,3%.
Identification of Potential Hub Genes ,Immune Cells and Target Drugs of Peri-Implantitis related to chromosome Using Bioinformatics Tool
Authors: Qin Zishun , Jiang Huaxiang , Wu JianXin , Zeng Hui , Hu Xi , Yang Fengrui , Wang Jun
Published: November 2022

Background：Peri-Implantitis (PI) is a pathological condition associated with dental plaque that occurs in the tissue around dental implant. The traditional methods of evaluating PI have limitations in clinical practice. Non-invasive and accurate diagnosis of PI is essential for determining the appropriate treatment. By integrating and analysing two microarray platform datasets from the GEO database, we aim to identify the diagnostic biomarkers of PI, find the target drugs , and guide the clinical diagnosis and treatment of PI.
Methods: The differentially expressed genes (DEG) of PI were identified by integrating two datasets (GSE57631 and GSE106090) into the GEO database using sva and limma packages of R. Then, the main biological functions of DEG were analyzed by Gene Ontology (GO) analysis, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis and Gene Set Enrichment Analysis (GSEA). The hub genes associated with PI were identified by WGCNA, and the protein-protein interaction (PPI) network was constructed by Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) and Cytoscape. The core genes associated with PI were determined through LASSO regression . Meanwhile, The content of immune cells in normal tissue and PI were evaluated using the CIBERSORT . Finally, target drugs and the target miRNA of PI chromosomes were found by Drug Signature Database and TargetScan respectively.
Results：A total of 425 DEG were found in PI, including 214 upregulated and 211 downregulated genes. GO analysis shows that DEGs were enriched in biological processes related to inflammation, the enriched pathways in the KEGG pathway analysis were Cytokine-cytokine receptor interaction, Chemokine signaling pathway, B cell receptor signaling pathway.The results of GSEA revealed that the gene expression of B cells was higher than myeloid (NES = 2.51) in Peri-Implantitis group. Ten hub genes associated with PI were found by WGCNA analysis. Two core genes (CD38 and IRF4) related to Peri-Implantitis were obtained by LASSO. 32 hub genes related to PI chromosomes were found by PPI network constructed by Cytoscape. 22 kinds of immune cells and 13 kinds of immune reaction processes related to PI were identified by CIBERSORT. Ten target drugs and ten target miRNA were found by Drug Signature Database and TargetScan respectively.
Conclusions: Through the bioinformatics analysis of merged datasets, the Hub genes, immune cells and target drugs related to Peri-Implantitis chromosomes were screened. The results can provide guidance for the clinical treatment of Peri-Implantitis.
Cost-Benefit Analysis of Magnetic Resonance Imaging Equipment in China: A Nationwide Survey
Authors: Fan Zhilei , Wei Yan , Xu Ningze , Huang Xiaolin , Cheng Jingliang , Chen Yingyao
Published: November 2022

Background: Facing the medical arms race and the pressing need for cost containment, hospital administrators in China have gained a growing interest in improving the financial efficiency of imaging examinations. This study aims to assess the cost-benefit situation of China’s magnetic resonance imaging (MRI) services and initially explore its relevant factors based on a nationwide survey.
Methods: Real-world data of 138 sets of MRI equipment were obtained from a nationwide retrospective investigation. Cost-benefit analysis and respective sensitivity analyses were performed from the hospital’s perspective. Ordinary least square (OLS) regression was introduced to identify the factors that influenced the benefit-cost ratio (BCR), taking a single MRI set as the unit of analysis.
Results: The average annual costs of MRI operation during 2013-2017 in Chinese hospitals was $701,146, of which the share of MRI imager accounted for 51.88%. The average annual revenues from MRI examination were $1219,527, and the benefit-cost ratio was around 1.74. Different scenarios were tested using sensitivity analyses, and the BCR still remained above 1.00 for the most unfavorable scenario (138.02%). In the hierarchical OLS model, the hospital-grade was recognized as the only significant factor among the covariates selected (P<0.01), yet the full model showed that factors at service level all had impacts on the BCRs (P<0.05), including the acquisition expense of MRI, maintenance costs, annual service amounts and the charge for an examination, with hospital-grade reversed being statistically insignificant (P>0.05).
Conclusions: The current MRI services at China’s medical institutions are cost-benefit from the hospital’s perspective. Nonetheless, high acquisition expense on MRI imagers still urges administrators of hospitals at different levels to choose appropriate type with consideration of their service capacity.
Trial registration: Not applicable
Preliminary in vitro cytotoxic evaluation of Uncaria gambier (Hunt) Roxb extract as a potential herbal-based pulpotomy medicament
Authors: Tan Bee Chin , Mahyuddin Alida , Sockalingam S Nagarajan MP , Zakaria Ahmad Shuhud Irfani
Published: November 2022

Background
The downfall of formocresol as a pulpotomy medicament highlights the importance of cytotoxic evaluation and the establishment of a safe concentration of dental material prior to its usage in the oral cavity. Uncaria gambir is a herbal plant that possesses antimicrobial, anti-inflammatory and antioxidant properties, suggesting its potential as an alternative medicament for pulpotomy. However, a study on its cytotoxicity is lacking. Here, we investigated the concentration and time-dependent toxicity of Uncaria gambir extract towards the M3CT3-E1 cell line and compared it with the gold standard pulpotomy medicament: mineral trioxide aggregate (MTA).
Methods
Uncaria gambir extracts at concentrations ranging from 1000 to 7.8 µg/ml and MTA eluates at 4- and 48 hours setting times were prepared. 10% dimethyl sulfoxide (DMSO) and culture media were used as positive and negative control respectively. Cell viability on days 1, 2, 3 and 7 were analysed using Alamar Blue and Live and Dead Cell assay. Any morphological cellular changes were evaluated using transmission electron microscopes (TEM). Data were analysed using a two-way mixed Analysis of Variance (ANOVA).
Results
The interaction between the concentration and exposure time on the fluorescence intensity of Uncaria gambir extract and MTA 48 hours was found to be statistically significant (p < 0.001). No cytotoxic effects on the cells were exerted by both MTA 48 hours and Uncaria gambir extract at a concentration below 500 µg/mL. TEM analysis and Live and Dead Cell assay for both materials were comparable to the negative control. No significant differences in fluorescent intensity were observed between Uncaria gambir extract at 500 µg/mL and MTA 48 hours (p > 0.05).
Conclusion
Uncaria gambir extracts at a maximum concentration of 500 µg/mL are non-cytotoxic over time and are comparable to the MTA.
An Explainable Deep Network Framework with Case-based Reasoning Strategies for Survival Analysis in Cancer
Authors: Liu Guanghui , Bichindaritz Isabelle
Published: November 2022

Survival analysis has currently become an essential statistical research hotspot that models the time-to-event information with data censorship handling. Such technique yields extensive applications in carcinoma treatment and prediction. Deep neural networks (DNNs) also exhibit unusual appeal for survival analysis because of their non-linear nature. However, DNNs are often described as “black box” models. A black box model is a model that is extremely hard or practically impossible to explain. In this study, we propose an explainable deep network framework for survival prediction in cancer. We utilize the strategy of the nearest distance retrieval in case-based reasoning (CBR) to provide useful insights into the inner workings of the deep network. First, we use an autoencoder network to reconstruct the features of a training input. We create a prototype layer, which can store the weight vector following the encoded input and to receive the output from the encoder. In this deep survival model network, the total loss function consists of four terms: the negative log partial likelihood function of the Cox model, the autoencoder loss, and two interpretability prototype distance terms. We use an adaptive weights approach to combine the four loss terms. The network that the prototype layer learns during training naturally comes with an explanation for each prediction. We also introduce Shapley Additive Explanation (SHAP) values to explain each feature importance that significantly contributes to the model’ predictions. This study employs cross-validation and the concordance index for assessing the predicting effect. Stringent cross-verification testing processes on two cancer methylation data sets demonstrate that the developed approach is effective.
Optimisation of methods for isolation of primary cancer cells from breast cancer tumour
Authors: Piwocka Oliwia , Musielak Marika , Ampuła Karolina , Piotrowski Igor , Adamczyk Beata , Fundowicz Magdalena , Suchorska Wiktoria Maria , Malicki Julian
Published: November 2022

Primary cell lines are an invaluable tool to explore cancer biology and molecular processes and investigate novel treatments. Despite their numerous advantages, primary cultures are laborious to obtain and maintain in culture thus rarely used in the laboratory. In this paper, we tested various methods for isolating primary breast cancer cultures that differed in enzymatic composition, incubation times and other methodologies. Finally, we optimised a method (Method 5) that gave rise to primary cell culture BC160. This approach combines mechanical disaggregation with enzymatic digestion by collagenase IV and hyaluronidase, followed by centrifugation. The cell line obtained by this method has a unique set of features with a strong influence of extracellular matrix remodelling genes. Primary cell lines have a high potential to become a model of choice, hence it is essential to elaborate and categorise isolation methods, develop approaches to separate heterogeneous cultures and investigate factors influencing the establishment of primary cell lines.
Oleuropein Against Gastric Cancer: A New Hope of Therapy
Authors: Türkdoğan Kürşad , Koçyiğit Abdurrahim , Güler Eray Metin , Özer Ömer Faruk , Demir Kübra , Uğur Halime
Published: November 2022

Oleuropein (OLE), the main phenolic compound of the olive fruit and leaves, has many healthful effects. Gastric cancer is the most fatal malignity in many parts of the world and it is generally related to harmful dietetic factors. The anticarcinogenic role of OLE in gastric cancer has not been studied sufficiently yet. In this study, we aimed to search the cytotoxic, genotoxic and apoptotic effects of OLE on gastric adeno cancer (G.CA) cells in vitro.
The performance of a standard cell line (G.CA) produced from G.CA cells was evaluated after a 24-hour exposure to OLE at varied dosages. The cytotoxicity, generation of reactive oxygen species (ROS), and genotoxicity were examined using the ATP analysis for viable cells, 2',7'-dichlorodihydrofluorescein-diacetate assay (H2DCF-DA), and alkaline single cell gel electrophoresis analysis (Comet Assay), respectively. Through the use of flow cytometry, the triggering of apoptosis was revealed.
OLE reduced G.CA cells viability (64%) at maximum concentration (500 μmol/L) and also resulted in approximately 100% DNA damage, 60% apoptosis and necrosis in G.CA cells depending on the increased doses. Malign cell viability was also significantly decreased in relation to growing amount intracellular reactive oxygen species (ROS) grades (p <0.05-0.001).
In conclusion, Oleuropein has shown very significant anticarcinogen effects against G.CA cells in vitro. Nutrition rich in olive and extra virgin olive oil seems to be both protective and therapeutic against gastric cancer and Oleuropein may be a new, potential chemotherapeutic agent in the near future.
Optimizing the appearance of plant-based foods: Impact of pigment and droplet characteristics on optical properties of model oil-in-water emulsions
Authors: Wannasin Donpon , McClements David Julian
Published: November 2022

Plant-based foods should mimic the appearance of the animal-based ones they are designed to replace, such meat, seafood, egg, milk, and their products. Each food is required to have specific optical properties, such as color and opacity, which depend on the selective absorption and scattering of light. In this study, oil-in-water emulsions containing plant-derived pigments were used as model plant-based foods. The pigments were selected to represent the three primary colors: turmeric (yellow), red beet (red), and butterfly pea flower (blue). We then investigated the impact of pigment and oil droplet characteristics on the optical properties of the model emulsions, including pigment type and concentration, and droplet size and concentration. Reflectance spectroscopy and colorimetry (L*, a*, b* values) were used to quantify the impact of these parameters on the optical properties of the emulsions. The chromaticness of the emulsions increased with increasing colorant concentration, increasing droplet size, and decreasing droplet concentration due to greater light absorption. The lightness of the emulsions increased with decreasing colorant concentration, decreasing droplet size, and increasing droplet concentration due to greater light scattering. This study provides a better understanding of the factors influencing the optical properties of plant-based foods, which could be used to optimize their appearances, thereby increasing consumer acceptance.