bluuebunny/crossref_metadata_2025 huggingface dataset:
Pelatihan Pemanfaatan Barang Bekas sebagai Media Pembelajaran di Taman Kanak-Kanak
Authors: Wahyudi Mohammad Dani , Cinantya Celia , Maimunah Maimunah
Published: May 2022

The problem in this community service activity is the use of learning media that is less varied. This is because most teachers are less creative in utilizing the objects around them as innovative learning media. Therefore, the solution used to overcome this problem is to carry out workshops on using used goods as learning media in Kindergarten. This activity aims to provide insight and skills to teachers at partner schools to use used materials around them in exciting learning media. This Community Service activity was conducted at the Pembina State Kindergarten, East Banjarmasin District, Banjarmasin City. The method used in this activity is a lecture, demonstration, and question and answer method. All teachers in the school participated in this activity. This training activity results in teachers gaining knowledge and skills in utilizing used goods in the surrounding environment in exciting and innovative learning media.
Sosialisasi Kebijakan Pelaksanaan Akreditasi Sekolah dan Madrasah bagi Kepala Sekolah dan Pengawas di Barito Selatan
Authors: Rahmaniati Rita , Bulkani Bulkani
Published: May 2022

There is a paradigm shift in the assessment of school/madrasah accreditation from an administration-based assessment (compliance) to a performance-based evaluation or rule to principles. AISP-2020 was developed with an emphasis on evaluating four assessment components, namely Graduate Quality, Learning Process, Teacher Quality, and School/Madrasah Management. The existence of these changes requires schools that will be the targets of accreditation need to understand the new instrument. This community service aims to provide insight and increase understanding of the 2020 IASP for school principals and supervisors. This service activity was carried out well and ran smoothly according to the previously planned plan. Socialization participants can understand IASP-2020 through test activities by filling out performance achievements with an accreditation simulation model. Thus this training can increase the knowledge and understanding of school principals and supervisors in South Barito Regency.
New Design Proposals for Shopping Centre Structures as a Result of COVID-19
Authors: Ergün Ruşen , Kutlu İzzettin
Published: May 2022

The COVID-19 pandemic, declared a pandemic by the World Health Organization, continues to be a serious threat to life. There is considerable anxiety due to the rapid spread of the disease and the continuous increase in patients and deaths. It is known that architecture changed significantly in various periods due to similar concerns. The study examines the effect of the COVID-19 process on architecture and provides design suggestions related to shopping centre designs, especially in the Mediterranean climate. The study will examine shopping centres, where users access spaces with many different functions simultaneously, investigating the harmful effects of the COVID-19 pandemic on architecture and propose new solutions by including users in the study. The survey method was used and analysed in the SPSS program. As a result, it is believed that this study will produce architectural solutions to the problems caused by COVID-19 and constitute a source for new research.
SPION based nanoformulations: bio-inspired design and functionalization strategies for applications in medicine
Authors: Tietze Rainer , Alexiou Christoph
Published: May 2022

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Biomedical applications in medicine are an area of research studied in great breadth, covering the various potential applications. Mimicking natural processes promises to be a successful strategy for several reasons. For example, physiological structures can generate drug delivery platforms that are better tolerated by the immune system. Furthermore, physiological movement patterns in flagella or contracting motions, which originate from unicellular organisms, are imi-tated. Further examples are stimuli-responsive tissue structures that serve the regeneration of bone material by stimulating pre-osteoblasts to proliferate. The examples of bioinspired SPIONs discussed in this review span the fields of drug delivery, imaging/diagnostics, nano/micromotion, and tissue engineering. All these concepts need to be evaluated regarding their technical feasibility and translatability into the clinic. Therefore, this text concludes with a general consideration for clinically proving such developments.
The Effect of Music Instrument Kacapi Suling "Ayun Ambing" Towards Reducing Blood Pressure of Hypertension
Authors: Herliana Irma , Hasanah Uswatun , Arianti Dewi
Published: May 2022

Background: Hypertension is still the most common complaint in Indonesia. Apart from causing some discomfort, complications of hypertension are also considered to be life-threatening. One therapy that can be used to lower blood pressure is music therapy. Kacapi suling is one of the traditional Sundanese music that is popular among the Sundanese people with a frequency of 50–75 Hz, 121 Kilobytes per second (Kbps), 76 decibels with a slow tempo.
Objective: This study aims to find out the effect of kacapi suling instrument music therapy on blood pressure in hypertensive patients.
Methods: This study used a Pre-Experimental Design in the form of a One-Group Pretest-Posttest with 20 respondents with hypertension. Data collection tools in the form of a sphygmomanometer, a questionnaire containing the respondent's biodata, gadgets, loudspeakers, and stationery. Instrumental music is played once with a duration of approximately 5 minutes using a device connected to a loudspeaker. Before and after blood pressure measurements were taken. Data analysis in this study using Wilcoxon.
Results: The results showed that the average systolic pre-test score was 142.86 while the post-test average was 135.24 with a p-value = 0.001. The average post-test diastolic value was 87.62 and the average post-test score was 84.29 with a p-value = 0.122.
Conclusion: There is an effect of kacapi suling “Ayun Ambing: instrument music on decreasing systolic blood pressure in hypertensive patients but there is no effect on diastolic blood pressure.
Hubungan Aktivitas Fisik dan Indeks Massa Tubuh dengan Gangguan Muskuloskeletal pada Mahasiswa Kedokteran Universitas Jember di Masa Pandemi Covid-19
Authors: Narwanto Muhammad Ihwan , Salsabila Syadza , Wulandari Pipiet
Published: May 2022

Pandemi COVID-19 mengakibatkan terjadinya perubahan gaya hidup, terjadi penurunan tingkat aktivitas fisik dan peningkatan indeks massa tubuh. Diketahui bahwa aktivitas fisik dan indeks massa tubuh merupakan faktor resiko terjadinya gangguan muskuloskeletal. Perkuliahan daring menurunkan aktifitas fisik dan meningkatkan waktu duduk. Tujuan penelitian ini untuk mengetahui hubungan antara aktivitas fisik dan indeks massa tubuh dengan gangguan muskuloskeletal pada mahasiswa kedokteran Universitas Jember di masa pandemi COVID-19. Penelitian dengan metode cross sectional yang diikuti oleh 248 mahasiswa Fakultas Kedokteran Universitas Jember. Kuisiouner digunakan untuk menilai perubahan aktifitas fisik sebelum dan saat pandemi, aktifitas fisik dan indeks massa tubuh saat pandemi. Kuesioner dibagikan secara online pada 27 Maret - 12 April 2021. Data dianalisis menggunakan uji deskriptif dan uji chi square. Perubahan aktivitas fisik mahasiswa sebelum dan saat pandemi, yaitu 69,4% mengalami penurunan aktivitas fisik, 19,4% tetap, dan 11,3% mengalami kenaikan aktivitas fisik. Tingkat aktivitas fisik mahasiswa saat pandemi, yaitu 40,3% aktifitas fisik sedang, 33,9% aktifitas fisik rendah, dan 25,8% aktifitas fisik tinggi. Indeks massa tubuh mahasiswa, 61,7% normal, 14,5% gemuk berat, 10,5% kurus ringan, 9,7% gemuk ringan dan 3,6% kurus berat. Sebanyak 67,3% mahasiswa mengalami gangguan muskuloskeletal dengan lokasi terbanyak di pinggang (66,5%), punggung (60,5%), dan leher atas (58,7%). Dari uji chi-square diketahui bahwa terdapat hubungan signifikan antara tingkat aktivitas fisik dan perubahan aktivitas fisik sebelum dan saat pandemi dengan gangguan muskuloskeletal dengan nilai p=0,034 dan p=0,047, sedangkan hubungan antara indeks massa tubuh dengan gangguan muskuloskeletal tidak signifikan (p=0,766). Kesimpulan penelitian adalah aktivitas fisik mahasiswa kedokteran Universitas Jember di masa Pandemi Covid-19 berhubungan dengan terjadinya gangguan musculoskeletal, sedangkan tidak demikian untuk indeks massa tubuh.
Analisis Komitmen Manajemen Rumah Sakit terhadap Kesiapsiagaan dalam Menghadapi Bencana di RSUD Indramayu
Authors: Fajriah Nurul , Jati Sutopo Patria , Setyaningsih Yuliani
Published: May 2022

Bencana merupakan peristiwa serta rangkaian peristiwa yang dapat mengancam dan mengganggu kehidupan serta penghidupan masyarakat. Pada tahun 2018 akibat dari gempa dan tsunami di Sulawesi tengah menghancurkan 18 rumah sakit dan 167 fasyankes. Keberadaan komitmen manajemen yang kokoh sangat diperlukan rumah sakit agar bisa meningkatkan kesiapan rumah sakit dalam menghadapi bencana. Tujuan penelitian ini untuk menganalisis komitmen manajemen dalam penerapan kesiapsiagaan bencana di RSUD Indramayu. Penelitian ini merupakan penelitian deskriptif dengan pendekatan kualitatif yang mengumpulkan data dilakukan dengan cara observasi, telaah dokumen, dan wawancara mendalam semi terstruktur. Ada 9 Informan yakni 2 Informan kuci, 4 informan utama dan 3 informan tambahan. Dimana data yang dihasilkan kemudian dianalis menggunakan interactive model. Hasil penelitian menunjukkan ada komitmen manajemen terkait organisasi penanggulangan bencana, sarana prasarana, prosedur, sumber daya, serta pelatihan dan pendidikan. Namun kinerja organisasi penanggulangan bencana belum berjalan maksimal. Sarana dan prasarana penanggulangan bencana memerlukan penambahan dan pemeriksaan rutin. Sebagian besar karyawan baru tidak mengetahui adanya prosedur penanggulangan bencana. Dan sebagian besar karyawan telah menerima pelatihan terkait penanggulangan bencana di RSUD Indramayu. Seluruh informan memiliki komitmen afektif. Analisis pelaksanaan penanggulangan bencana menggunakan Indikator Rencana Bencana Rumah Sakit (HDP) hanya 7 indikator yang memenuhi standar dan belum melakukan self assessment terkaitIndeks Keselamatan Rumah Sakit (HSI) di RSUD Indramayu.
Assessment of functional shunting in patients with sickle cell disease
Authors: Afzali-Hashemi Liza , Václavů Lena , Wood John C. , Biemond Bart J. , Nederveen Aart J. , Mutsaerts Henk J.M.M. , Schrantee Anouk
Published: May 2022

Silent cerebral infarcts (SCI) are common in patients with sickle cell disease (SCD) and are thought to be caused by a mismatch between oxygen delivery and consumption. Functional cerebrovascular shunting is defined as reduced oxygen offloading due to the rapid transit of blood through the capillaries caused by increased flow and has been suggested as a potential mechanism underlying reduced oxygenation and SCI. We investigated the venous arterial spin labeling signal (VS) in the sagittal sinus as a proxy biomarker of cerebral functional shunting, and its association with hemodynamic imaging and hematological laboratory parameters. We included 28 children and 38 adults with SCD, and ten healthy racematched adult controls. VS, cerebral blood flow (CBF), velocity in the brain feeding arteries, oxygen extraction fraction (OEF) and cerebral metabolic rate of oxygen (CMRO2) were measured before and after acetazolamide administration. VS was higher in patients with SCD compared to controls (P<0.01) and was increased after acetazolamide administration in all groups (P<0.01). VS was primarily predicted by CBF (P<0.01), but CBF-corrected VS was also associated with decreased CMRO2 (P<0.01). Additionally, higher disease severity defined by low hemoglobin and increased hemolysis was associated with higher CBF-corrected VS. Finally, CMRO2 was negatively correlated with fetal hemoglobin, and positively correlated with lactate dehydrogenase, which could be explained by changes in oxygen affinity. These findings provide evidence for cerebral functional shunting and encourage future studies investigating the potential link to aberrant capillary exchange in SCD.
The Application of Catalytic Ozonation Technique using UV and Granular Activated Carbon (GAC) for Eliminating in Waste Phenol, COD, and 1,1,2,2-Tetrachloroethane
Authors: Ikhsandy Ferry , Bismo Setijo , Karamah Eva Fathul
Published: May 2022

Process eliminating compounds of phenol, Chemical Oxygen Demand (COD), and 1,1,2,2-tetrachloroethane using catalytic ozonation technique with catalyst Granular Activated Carbon (GAC) combination with Ultra Violet (UV) light emission performed in this study. This study aimed to obtain the effectiveness of applications catalytic ozonation technique using system configuration Ozone/GAC and Ozone/UV/GAC to eliminate waste phenol 1,1,2,2-tetrachloroethane COD with circulation time (0, 15, 30, 45, 60, and 120 minutes). The wastewater was derived from the wastewater Laboratory of Polyester Industrial in Bogor. The results were analyzed, comprised of COD with Ferrous Ammonium Sulphate (FAS) method, phenol using aminoantipirin method, and 1,1,2,2-tetrachloroethane with Gas Chromatography-Flame Ionization Detector (GC-FID) method. The result of study shown that the configuration of the Ozone/ UV/GAC with an initial concentration of phenol 58,00 mg/L, COD 72,00 mg/L and 1,1,2,2-tetrachloroethane 32,96 mg/L resulted in the percentage of eliminating phenol 57,76%, COD 66,67% and 1,1,2,2-tetrachloroethane 98,74% while the configuration of Ozone/GAC with an initial concentration of phenol 55,00 mg/L, COD 72,00 mg/L and 1,1,2,2-tetrachloroethane 37,70 mg/L resulted in percentage of eliminating phenol 50,91%, COD 55,56% and 1,1,2,2-tetrachloroethane 100%ABSTRAKProses penyisihan senyawa fenol, Chemical Oxygen Demand (COD) dan 1,1,2,2-tetrakloroetana menggunakan teknik ozonasi katalitik dengan katalis Granular Activated Carbon (GAC) yang dikombinasikan dengan emisi sinar Ultra Violet (UV) dilakukan dalam penelitian ini. Tujuan dari penelitian ini untuk memperoleh efektivitas aplikasi teknik ozonasi katalitik menggunakan sistem konfigurasi, yaitu: Ozon/GAC dan Ozon/UV/GAC dalam penyisihan limbah fenol, COD dan 1,1,2,2-tetrakloroetana dengan waktu sirkulasi (0, 15, 30, 45, 60, dan 120 menit). Limbah cair yang digunakan berasal dari limbah cair Laboratorium Industri Polyester di daerah Bogor. Analisis yang dilakukan meliputi analisis COD dengan metode Ferro Ammonium Sulfat (FAS), analisis Fenol dengan menggunakan metode aminoantipirin dan analisis 1,1,2,2-tetrakloroetana dengan metode Gas Chromatography-Flame Ionization Detector (GC-FID). Setelah dilakukan penelitian, diketahui bahwa konfigurasi Ozon/UV/GAC dengan konsentrasi awal fenol 58,00 mg/L, COD 72,00 mg/L dan 1,1,2,2-tetrakloroetana 32,96 mg/L menghasilkan persentase penyisihan senyawa fenol 57,76%, COD 66,67% dan 1,1,2,2-tetrakloroetana 98,74% sedangkan konfigurasi Ozon/GAC dengan konsentrasi awal fenol 55,00 mg/L, COD 72,00 mg/L dan 1,1,2,2-tetrakloroetana 37,70 mg/L menghasilkan persentase penyisihan senyawa fenol 50,91%, COD 55,56% dan 1,1,2,2-tetrakloroetana 100%.
Speech Acts and Argumentative Resources in the Speeches Given in Front of the European Parliament by King Juan Carlos I and by King Felipe VI
Authors: Tigris Simona Luiza
Published: May 2022

This paper focuses on comparing the speeches given in front of the European Parliament by King Juan Carlos I on the 14th of May 1986 and by King Felipe VI on the 7th of October 2015 from a pragma-rhetoric perspective. It highlights certain speech acts that may constitute the backbone of the two speeches, as they refer to key topics such as terrorism, the preservation of European values, a more integrated Europe, etc. Moreover, it also attempts to identify significant argumentative resources that were used such as rhetorical figures and various types of arguments. Both speeches reflect some of the issues that the European Union had to tackle at the time they were delivered. King Juan Carlos I urges for a more united Europe and he puts emphasis on the technological challenges that lie ahead. He uses anaphors, a paradox and the ad consequentiam argument. King Felipe VI points out the need of the European Union to identify new internal and external objectives in a more globalized world. He also states that, by joining their forces together, the European states can offer help to the thousands of refugees who were migrating back then mostly from Syria, Afghanistan and Iraq so as to escape war. King Felipe VI uses in his argumentation anaphors, the circular reasoning fallacy, the ad consequentiam argument and the appeal to authority. As a discursive strategy, he mentions that the European Union is “our great common project”, making thus reference to the concept of “project of life” as it was defined by the Spanish philosopher José Ortega y Gasset. Both orators employ personifications of Spain. They both throw a strong light on the role of Spain within the European Union. The text analysis application AntConc is used in order to detect the most used words in their speeches.
Pemanfaatan Media Sosial Sebagai Sarana Pembentukan Karakter Kristiani Tingkat Sekolah Menengah Pertama
Authors: Saingo Yakobus Adi
Published: May 2022

Tujuan penelitian ini adalah untuk mengkaji peran guru Pendidikan Agama Kristen dalam pemanfaatan media sosial sebagai sarana pembentukan karakter kristiani di tingkat Sekolah Menengah Pertama.  Dimana pembahasannya juga akan diperdalam dengan mendeskripsikan mengenai bentuk media sosial yang sering digunakan oleh guru Pendidikan Agama Kristen, penggunaan media sosial secara umum oleh guru Pendidikan Agama Kristen, serta dampak penyalahgunaan media sosial oleh peserta didik ketika tidak mendapatkan arahan dan bimbingan yang benar dalam pemanfaatam teknologi digital (khususnya media sosial) oleh guru Pendidikan Agama Kristen. Metode peneltian yang digunakan adalah studi kepustakaan dengan pendekatan deskriptif untuk menggambarkan keadaan umum yang dialami guru Pendidikan Agama Kristen dan peserta didik terkait penggunaan media sosial. Subjek penelitian ini adalah guru Pendidikan Agama Kristen dan peserta didik di lingkungan sekolah. Dalam kajian pustaka ini, peneliti juga memberikan solusi mengenai upaya guru Pendidikan Agama Kristen dalam pemanfaatan media sosial sebagai sarana pembentukan karakter kristiani peserta didik di tingkat Sekolah Menengah Pertama.
Modelo de Negocios Canvas y Calidad de Servicios en Clientes del Sector Hospedaje de la Región Junín
Authors: Paredes-Pérez Marco A. J. , Palomino-Crispin Antonio E. , Gonzales-Peralta Carla F.
Published: May 2022

El empleo de un modelo de negocios para brindar servicios de calidad en establecimientos de hospedaje es esencial para el desarrollo de este sector; actualmente pocas investigaciones tratan este tema. El objetivo principal del estudio fue determinar la asociación del modelo de negocios canvas y la calidad de servicios en clientes de empresas de hospedaje de la región Junín, la investigación fue de tipo básica, nivel relacional con un diseño descriptivo-correlacional; la muestra estuvo conformada por los clientes de servicio de hospedaje de la región Junín, la muestra estuvo conformada por 80 clientes, la técnica de muestreo fue no probabilística por conveniencia (Otzen & Manterola, 2017), el enfoque cuantitativo, el tipo de investigación por su finalidad fue básico, el nivel fue descriptivo y el diseño no experimental-transversal; los métodos teóricos fueron inductivo-deductivo y el método empírico fue el observacional; la prueba estadística empleada fue el coeficiente de asociación tau b de Kendall, las escalas fueron ordinales, los instrumentos fueron cuestionarios elaborados de acuerdo a la revisión de la literatura basados en Osterwalder y Pigneur (2011) y Matsumoto-Nishizawa, (2014); el tratamiento estadístico se realizó en SPSS 25; el resultado principal fue que existe asociación significativa entre el modelo de negocios canvas y calidad de servicios en clientes del sector hospedaje de la región Junín, puesto que el p-valor hallado fue de 0,634 y el estadístico tau b de Kendall fue de 0,001 reflejando una relación significativa.
A crônica-canção de Chico Buarque
Authors:   Universidade Estadual de Londrina, Pessoa Marcelo
Published: May 2022

Our work investigates Brazilian songwriter Chico Buarque’s appropriation of elements found in columns or chronicles by writers such as Rubem Braga, Carlos Drummond de Andrade, João do Rio, Carlos Heitor Cony, Machado de Assis, in his songwriting process. In order to do so, this present work focuses on cultural and literary studies, which predict the interconnection among media, literature and society, based on symbolic correlations between the literary genre chronicle and the verses sung by Chico Buarque. Chico Buarque, when appropriating specific elements from prose production in his songwriting, resembles the literary procedures of our greatest chronicle writers. That approach can be easily seen at times when Buarque performs in his lyrics the work that would be typically considered to be that one of a newspaper column writer. After a brief discussion about Music, song and lyrics, the following chapter “Chronicle: facets and dialogues” brings a brief history of the twentieth century critique, emphasizing the idea of the chronicle as a literary genre. At another moment, we’ll be dealing with the novel Estorvo, considered to be an extended chronicle. In the chapter “The Chronicle-Song of Chico Buarque”, we’ll be analyzing some of his songs. To guide the analysis of the conflicts between chronicle and song, we’ll be using chronicle genre classifications as presented by José Marques de Melo, comparing them with the ideas conceived by other critics such as Antônio Cândido, Davi Arrigucci Jr. and Massaud Moisés. In the chapter “Analyzing the Corpus”, we’ll be studying Buarque’s lyrics referring to the literary chronicle genre. Finally, we realize that the songs created by Chico Buarque can be seen as song chronicles, once they represent a sub product of people’s social and cultural experiences on a daily basis.
Methodological landscape of qualitative works on open science
Authors: Manco Vega Alejandra
Published: May 2022

This review aims to examine the characteristics of the qualitative articles on open science. The bibliographic searches were made in Scopus, Web of Science, Semantic Scholar and Google Scholar using open science as a keyword. A total of 28 relevant articles were finally selected. It was found that the most used techniques are interviews and document analysis. The type of research design usually is descriptive and exploratory. There is a lack of a formal sampling strategy in the majority of the articles, although when mentioned the most common types are snowball, purposive, criterion, convenience and self-selective. The study sample is usually small in the case of interviews and case studies. The limitations are related to two issues: specificities of exploratory research and generalization. Also, the majority of article corpuses do not publish their research data. In conclusion, the chosen methodologies are rather traditional qualitative methods. For instance, none of the revised papers in this corpus used digital qualitative methods. The usage of only descriptive and exploratory research design may indicate that open science is still a fairly young field of research. Finally, qualitative research on open science is frequently very localized.
La utilidad de la integración de la Psicoterapia Analítica-Funcional y la Terapia de Aceptación y Compromiso (FACT) para mejorar el estrés laboral: Dos estudios de caso
Authors: Macías Morón Juan José , Valero Aguayo Luís
Published: May 2022

Se presenta la aplicación de un programa breve de intervención basado en la Terapia de Aceptación y Compromiso (ACT) y la Psicoterapia Analítica Funcional (FAP), que denominamos FACT breve, para mejorar la salud laboral y las relaciones interpersonales de dos empleados en una empresa agrícola. La intervención se llevó a cabo de manera individual durante un mes y medio, con un total de tres sesiones con cada participante. En la primera sesión se pasaron las medidas pretest y en la cuarta las postest. Se realizó también una sesión de seguimiento a los tres meses. La evaluación se realizó en las siguientes variables dependientes: el Cuestionario de Salud General (GHQ-12); la Escala de Observación de Recompensa Ambiental (EROS); y la subescala de bienestar laboral de la Escala de Bienestar Psicológico (EBP). Los resultados muestran una disminución de los problemas en la salud general, y un aumento del bienestar laboral y psicológico en ambos participantes. Además, los empleados mejoraron su relación interpersonal, que estaba muy deteriorada. Esta intervención corresponde el primer intento con FACT aplicado en el contexto laboral para mejora la salud de los empleados en un formato breve. Asimismo, se hace énfasis en el análisis en la integración de procesos y modelos con principios filosóficos comunes, que pueden converger en una generación de terapias basadas en la evidencia y en el análisis funcional y la conducta clínicamente relevante como base para producir cambios.
¿Es útil la intervención psicológica en las Unidades de Rehabilitación Cardíaca?
Authors: Valls Lázaro Esperanza
Published: May 2022

Las enfermedades cardiovasculares (ECV) están reduciendo su impacto gracias a la prevención y control de sus factores de riesgo. La rehabilitación cardíaca pretende fomentar una gestión saludable de dichos factores, aunque, en España, la dotación de programas de rehabilitación (PRC) está por debajo de lo recomendado y menor aún el porcentaje que incluye asistencia psicológica. Este estudio examina los resultados obtenidos en factores psicosociales de riesgo cardiaco en 905 pacientes cardíacos adscritos a un PRC multidisciplinar, según la participación o no en un programa psicológico (PP) incluido en el programa general. Resultados: Los participantes del PP (76.6%) mejoraron significativamente en todas las variables evaluadas, con tamaños del efecto moderados, destacando mejorías en depresión, ira, ansiedad y calidad de vida.Los no participantes en PP(23.4%) obtuvieron resultados más limitados y tamaños del efecto menores. Conclusión: Se resalta la contribución beneficiosa de la intervención psicológica en el marco de los PRC por lo que se reclama aumentar la presencia de dichas actuaciones.
Terapia basada en la compasión: regulación emocional, apego y salud mental
Authors: Ocaña Blasco Kristel , Lacomba-Trejo Laura , Alonso-Llácer Lorena , Pérez-Marín Marián
Published: May 2022

Los sucesos vitales estresantes (SVE) pueden influir en nuestras vinculaciones, y con ello en: la compasión, la regulación emocional y en nuestro bienestar físico y psicológico. El objetivo del presente artículo es proponer e implementar un programa de intervención basado en la compasión (TBC). Tras la firma del consentimiento informado, los participantes (n=8) respondieron cuestionarios sobre vinculaciones afectivas, regulación emocional, compasión, (SVE) y emocionalidad. Nuestros resultados previos al tratamiento muestran perfiles de desajuste marcados por la vinculación insegura, las dificultades de regulación, la baja autocompasión y la elevada emocionalidad negativa. Tras el tratamiento, fueron más ajustados, destacando una mejor salud mental. Como conclusión, creemos que la TBC puede mejorar la salud física y mental, a través del fortalecimiento de los vínculos de apego.
Regulación emocional y terapias psicológicas empíricamente apoyadas: Confluencias, complementariedades y divergencias
Authors: De los Santos Darío Augusto
Published: May 2022

Teniéndose como referencia el Modelo Procesual Extendido de regulación emocional de Gross (2015a) se realiza un breve relevamiento de diversos conceptos y procesos provenientes de distintos ámbitos de la investigación básica y aplicada vinculados con las terapias contextuales y cognitivo-conductuales. Esto permite vincular distintos procesos de cambio con los componentes de las etapas de regulación contempladas en el modelo. Se propone que en algunos de estos procesos de cambio el sistema de segundo orden se enfocaría principalmente en los componentes del sistema de valoración que da lugar a la emoción (por ej. modificación, distracción o reevaluación de la situación), mientras que en otros tendría como objeto principal sus propios procesos, especialmente los de la etapa de identificación (por ej. aceptación, atención o reevaluación de la emoción), aunque no exclusivamente. Las intervenciones de las terapias cognitivo-conductuales tradicionales parecen promover el uso de estrategias orientadas a producir cambios sobre todo en el sistema de valoración de primer orden, mientras que, las terapias contextuales y cognitivo-conductuales más recientes se focalizan mucho más en los procesos de la etapa de identificación del sistema de segundo orden. Estas divergencias se aprecian más claramente cuando se considera el lugar destacado que ocupa la aceptación, la consciencia emocional y el distanciamiento/defusión cognitiva en estas últimas.
Carbon Capture Materials and Technologies: A Review
Authors: Luedtke Zachary , Sun Zhao , Aro Matthew , Ton Sam
Published: May 2022

The United States emitted 5.27 billion tonnes of carbon dioxide into the atmosphere in 2018, less than one-sixth of the global emissions that year. The immense amount of greenhouse gases in the air have a detrimental effect on the planet. Rising global temperatures, rising sea levels, drought, wildfires, and other natural disasters are all being accelerated because of carbon emissions. Carbon capture is one solution that could reduce emissions tremendously. The topics of energy consumption, transportation phenomena, and thermodynamics of a wide range of carbon capture methods will be discussed.

Keywords: Climate Change, Post-combustion, Carbon Dioxide, Carbon Capture, Absorption, Desorption
Inflammatory Microenvironment Accelerates Bone Marrow Mesenchymal Stem Cell Aging
Authors: Peng Xin , Zhou Xin , Yin Ying , Luo Beibei , Liu Yang , Yang Cheng
Published: May 2022

MSC senescence is considered a contributing factor in aging-related diseases. We investigated the influence of the inflammatory microenvironment on bone marrow mesenchymal stem cells (BMSCs) under aging conditions and the underlying mechanism to provide new ideas for stem cell therapy for age-related osteoporosis. The BMSCs were cultured until passage 3 (P3) (young group) and passage 10 (P10) (aging group) in vitro. The supernatant was collected as the conditioned medium (CM). The young BMSCs were cultured in the CM of P3 or P10 cells. The effects of CM from different groups on the aging and stemness of the young BMSCs were examined. A Quantibody® mouse inflammation array on serum extracts from young (aged 8 weeks) and old (aged 78 weeks) mice was performed, and differentially expressed factors were screened out. We discovered that the CM from senescent MSCs changed the physiology of young BMSCs. Systemic inflammatory microenvironments changed with age in the mice. In particular, the pro-inflammatory cytokine IL-6 increased, and the anti-inflammatory cytokine IL-10 decreased. The underlying mechanism was investigated by GO and KEGG analyses, and there was a change in the JAK-STAT signaling pathway, which is closely related to IL-6 and IL-10. Collectively, our results demonstrated that the age-related inflammatory microenvironment has a significant effect on the biological functions of BMSCs. Targeted reversal of this inflammatory environment may provide a new strategy for stem cell therapy to treat aging-related skeletal diseases.
Microalgal Biomass as Feedstock for Bacterial Production of PHA: Advances and Future Prospects
Authors: Tan Florence Hui Ping , Nadir Najiah , Sudesh Kumar
Published: May 2022

The search for biodegradable plastics has become the focus in combating the global plastic pollution crisis. Polyhydroxyalkanoates (PHAs) are renewable substitutes to petroleum-based plastics with the ability to completely mineralize in soil, compost, and marine environments. The preferred choice of PHA synthesis is from bacteria or archaea. However, microbial production of PHAs faces a major drawback due to high production costs attributed to the high price of organic substrates as compared to synthetic plastics. As such, microalgal biomass presents a low-cost solution as feedstock for PHA synthesis. Photoautotrophic microalgae are ubiquitous in our ecosystem and thrive from utilizing easily accessible light, carbon dioxide and inorganic nutrients. Biomass production from microalgae offers advantages that include high yields, effective carbon dioxide capture, efficient treatment of effluents and the usage of infertile land. Nevertheless, the success of large-scale PHA synthesis using microalgal biomass faces constraints that encompass the entire flow of the microalgal biomass production, i.e., from molecular aspects of the microalgae to cultivation conditions to harvesting and drying microalgal biomass along with the conversion of the biomass into PHA. This review discusses approaches such as optimization of growth conditions, improvement of the microalgal biomass manufacturing technologies as well as the genetic engineering of both microalgae and PHA-producing bacteria with the purpose of refining PHA production from microalgal biomass.
Viral Vectors for the in Vivo Delivery of CRISPR Components: Advances and Challenges
Authors: Asmamaw Mengstie Misganaw
Published: May 2022

The Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR) and its accompanying protein (Cas9) are now the most effective, efficient, and precise genome editing techniques. Two essential components of the CRISPR/Cas9 system are guide RNA (gRNA) and CRISPR-associated (Cas9) proteins. Choosing and implementing safe and effective delivery systems in the therapeutic application of CRISPR/Cas9 has proven to be a significant problem. For in vivo CRISPR/Cas9 delivery, viral vectors are the natural specialists. Due to their higher delivery effectiveness than other delivery methods, vectors such as adenoviral vectors (AdVs), adeno-associated viruses (AAVs), and lentivirus vectors (LVs) are now commonly employed as delivery methods. This review thoroughly examined recent achievements in using a variety of viral vectors as a means of CRISPR/Cas9 delivery, as well as the benefits and limitations of each viral vector. Future thoughts for overcoming the current restrictions and adapting the technology are also discussed.
New Prognostic Gene Signature and Immune Escape Mechanisms of Bladder Cancer
Authors: Jiang Yi , Zeng Zhenhao , Xiong Situ , Jiang Ming , Huang Gaomin , Zhang Chiyu , Xi Xiaoqing
Published: May 2022

Background: The immune microenvironment profoundly affects tumor prognosis and therapy. The present study aimed to reveal potential immune escape mechanisms and construct a novel prognostic signature via systematic bioinformatic analysis of the bladder cancer (BLCA) immune microenvironment.

Patients and Methods: The transcriptomic data and clinicopathological information for patients with BLCA were obtained from The Cancer Genome Atlas (TCGA). Consensus clustering analysis based on the CIBERSORT and ESTIMATE algorithms was performed with patients with BLCA, which divided them into two clusters. Subsequently, the differentially expressed genes (DEGs) in the two were subjected to univariate Cox and least absolute shrinkage and selection operator (LASSO) regression analyses to identify prognostic genes, which were used to construct a prognostic model. The predictive performance of the model was verified by receiver operating characteristic (ROC) and Kaplan–Meier (K-M) analyses. In addition, we analyzed the differentially altered immune cells, mutation burden, neoantigen load, and subclonal genome fraction between the two clusters to reveal the immune escape mechanism.

Results: Based on the ESTIMATE and clustering analyses, patients with BLCA were classified into two heterogeneous clusters: ImmuneScoreH and ImmuneScoreL. Univariate Cox and LASSO regression analyses identified CD96 (HR = 0.83) and IBSP (HR = 1.09), which were used to construct a prognostic gene signature with significant predictive accuracy. Regarding potential immune escape mechanisms, ImmuneScoreH and ImmuneScoreL were characterized by inactivation of innate immune cell chemotaxis. In ImmuneScoreL, a low tumor antigen load might contribute to immune escape. ImmuneScoreH featured high expression of immune checkpoint molecules.

Conclusion: CD96 and IBSP were considered prognostic factors for BLCA. Innate immune inactivation and a low tumor antigen load may be associated with immune escape mechanisms in both clusters. Our research complements the exploration of the immune microenvironment in BLCA.
Highly Sensitive Detection of Carcinoembryonic Antigen via an Electrochemical Platform Fabricated by AuNPs/Streptavidin/Reduced Graphene Oxide
Authors: Guo Yang , Feng Liang
Published: May 2022

Tumor markers are one of the important indicators for early cancer diagnosis. As a new analytical method, electrochemical immunosensing analysis has the advantages of high sensitivity, good selectivity, and rapid detection, which is of great significance for the detection of tumor markers. In this work, an AuNP/reduced graphene oxide (AuNP/rGO) composite was synthesized. We used it for electrochemical sensor fabrication with the assistance of the biotin–streptavidin protein (SA) system to further amplify the signal to achieve sensitive detection of carcinoembryonic antigen (CEA). In addition, AuNPs have been incorporated due to their good electrical conductivity and biocompatibility, which can accelerate electron transfer at the electrode interface and improve the loading capacity to capture antibodies. The fabricated AuNPs/SA/rGO has a large working surface area and high material utilization ratio, which improves the catalytic capacity of H2O2 reduction and effectively amplifies the current signal. The linear range of the response current signal of the sensor toward the CEA concentration is 20 fg/ml to 200 ng/ml, and the limit of detection can achieve 6.2 fg/ml. In addition, the fabricated immunosensor has good reproducibility, selectivity, and stability.
Research Progress and the Development Trend of the Utilization of Crop Straw Biomass Resources in China
Authors: Yang Wei , Li Xiaohua , Zhang Yutao
Published: May 2022

The utilization of crop straw biomass resources is highly emphasized by governments and academia in recent decades. Based on the core databases of the literature in China National Knowledge Infrastructure (CNKI) academic journals, CiteSpace software is used to analyze and process the hotspots, and this study proposed the primary coverage and evolutionary trends of research on the utilization of crop straw resources. The thesis proposes the research development trend for improving the institutional mechanism of the utilization of crop straw resources, strengthening technology research and development, exploring the economic model of green cycle agriculture, accelerating the construction of the industrial system, and designing new paths of resource utilization in multiple ways, which helps estimate the development trend of the utilization of crop straw resources and provide inspiration and direction for future research and practices.
In Vitro Activity of MRX-8 and Comparators Against Clinical Isolated Gram-Negative Bacilli in China
Authors: Wu Shi , Yin Dandan , Zhi Peiyuan , Guo Yan , Yang Yang , Zhu Demei , Hu Fupin
Published: May 2022

To evaluate in vitro antibacterial activity of MRX-8 against gram-negative bacteria recently isolated from China, 765 clinical isolates were collected randomly from 2017 to 2020, including Enterobacterales and P. aeruginosa and A. baumannii, S. maltophilia, B. cepacia, Alcaligenes app. and Haemophilus spp. isolates. All strains were performed with antimicrobial susceptibility testing by broth microdilution method according to the CLSI 2021. Antimicrobial agents included MRX-8, polymyxin B, colistin, amikacin, ceftriaxone, ceftazidime, cefepime, ceftazidime-avibactam, cefoperazone-sulbactam, meropenem, ciprofloxacin, ampicillin, ampicillin-sulbactam and levofloxacin. For carbapenem-susceptible and carbapenem-resistant E.coli isolates, the MIC50/90 of MRX-8 was 0.125/0.25 mg/L and 0.06/0.125 mg/L, respectively. For carbapenem-susceptible and carbapenem-resistant K. pneumoniae isolates, the MIC50/90 of MRX-8 was 0.25/0.5 mg/L and 0.125/0.5 mg/L, respectively. For polymyxins (polymyxin B and colistin)-resistant E. coli and K. pneumoniae, MIC50 of MRX-8 was 4-16 mg/L and MIC90 was >32 mg/L. The MIC50 and MIC90 of MRX-8 for other Klebsiella spp. except K. pneumoniae, Citrobacter spp., S. enterica and Shigella spp. isolates ranged 0.06-0.125 mg/L and 0.06-0.25mg/L, respectively. For Morganella spp., Proteus spp., Providencia spp., Serratia spp., S. maltophilia and B. cepacia, all MIC50 of MRX-8 was >32mg/L. For carbapenem susceptible and resistant P. aeruginosa, the MIC50 and MIC90 of MRX-8 was both 1mg/L, and that for A. baumannii was 0.5mg/L and 0.5-1mg/L. For Alcaligenes spp. and Haemophilus spp., MIC50/90 was 1/4 mg/L and 0.25/0.5 mg/L. MRX-8 was more effective against most clinically isolated gram-negative isolates, including carbapenem-resistant E. coli, K. pneumoniae, P. aeruginosa and A. baumannii, highlighting its potential as valuable therapeutics.
Long Lasting Antibodies From Convalescent Pertussis Patients Induce ROS Production and Bacterial Killing by Human Neutrophils
Authors: Kroes Michiel M. , van Vliet Lars C. , Jacobi Ronald H. J. , Kuipers Betsy , Pieren Daan K. J. , Miranda-Bedate Alberto , van Els Cécile A. C. M. , Pinelli Elena
Published: May 2022

Pertussis is a respiratory infection caused by the Gram-negative bacterium Bordetella pertussis. Despite high vaccination coverage this disease remains a public health concern worldwide. A better understanding of the protective immune responses to B. pertussis is required for the development of improved vaccines. The aim of this study was to determine the production of reactive oxygen species (ROS) by human neutrophils in response to B. pertussis and to determine the contribution of opsonizing antibodies from convalescent pertussis patients in this response. The serum samples from convalescent patients were taken at <3, 9, 18 and 36 months after diagnosis of pertussis. Also included were sera from healthy age-matched controls. We show that neutrophils produced high levels of ROS in response to opsonized, compared to non-opsonized, B. pertussis and that this effect was independent of the time the convalescent serum samples were taken. This indicates the presence of functional opsonizing antibodies up to 3 years after B. pertussis infection. While opsonization of B. pertussis with serum samples from uninfected controls also induced ROS production, sera from infected individuals induced significantly higher ROS levels. Spearman correlations analysis showed that IgG antibodies targeting fimbriae3 followed by pertactin, and BrkA correlate with ROS production. Additionally, we observed that neutrophils killed opsonized B. pertussis in a ROS-dependent manner. Searching for other antigen-specific antibodies from convalescent pertussis patients involved in ROS production by neutrophils may assist in the identification of novel antigens to improve the current pertussis vaccines.
QuantiFERON-Cytomegalovirus Assay for Prediction of Cytomegalovirus Viremia in Kidney Transplant Recipients: Study From High Cytomegalovirus Seroprevalence Country
Authors: Pongsakornkullachart Kritsada , Chayakulkeeree Methee , Vongwiwatana Attapong , Kantakamalakul Wannee , Skulratanasak Peenida , Phoompoung Pakpoom
Published: May 2022

Background

Early studies showed the utility of pretransplant QuantiFERON-Cytomegalovirus (QF-CMV) assays for CMV-disease prediction post kidney transplant (KT). However, recent data are conflicting.

Methods

This prospective cohort study enrolled adult patients undergoing KT between July 2017 and May 2019. Patients with antithymocyte globulin therapy or negative pretransplant CMV IgG were excluded. QF-CMV assays were performed on transplantation day and one month thereafter, and CMV viral loads were obtained 1, 3, and 6 months posttransplantation. The primary outcome was CMV viremia within 6 months. The QF-CMV assay–posttransplant CMV viremia association was analyzed.

Results

Fifty-five patients were enrolled (male, 58.2%; mean (SD) age, 46.5 (10.2) years). Fifty-two (94.5%) received CMV-seropositive donor kidneys. Over 6 months, 29 patients developed CMV viremia (52.7%), with 14 (25.5%) having significant viremia requiring antiviral therapy. The CMV-viremia incidence of patients with nonreactive and reactive baseline QF-CMV assays did not differ significantly (55.3% and 47.1%; p = 0.573). Among patients with reactive pretransplant QF-CMV assays, there was a trend toward a lower incidence of CMV viremia for those who were persistently reactive at 1 month after KTs, although there was no statistically significant difference (50% vs 83%; p = 0.132).

Conclusions

Our study could not support the use of single-timepoint pretransplant or 1-month posttransplant QF-CMV assays as a predictor for posttransplant CMV viremia in CMV seropositive KT recipients. Investigation of the association between dynamic QF-CMV-status changes and CMV-viremia incidence are needed.
Linking Haptic Parameters to the Emotional Space for Mediated Social Touch
Authors: Rognon Carine , Stephens-Fripp Benjamin , Hartcher-O'Brien Jess , Rost Bob , Israr Ali
Published: May 2022

Social touch is essential for creating and maintaining strong interpersonal bonds amongst humans. However, when distance separates users, they often rely on voice and video communication technologies to stay connected with each other, and the lack of tactile interactions between users lowers the quality of the social interactions. In this research, we investigated haptic patterns to communicate five tactile messages comprising of four types of social touch (high five, handshake, caress, and asking for attention) and one physiological signal (the pulse of a heartbeat), delivered on the hand through a haptic glove. Since social interactions are highly dependent on their context, we conceived two interaction scenarios for each of the five tactile messages, conveying distinct emotions being spread across the circumplex model of emotions. We conducted two user studies: in the first one participants tuned the parameters of haptic patterns to convey tactile messages in each scenario, and a follow up study tested naïve participants to assess the validity of these patterns. Our results show that all haptic patterns were recognized above chance level, and the well-defined parameter clusters had a higher recognition rate, reinforcing the hypothesis that some social touches have more universal patterns than others. We also observed parallels between the parameters' levels and the type of emotions they conveyed based on their mapping in the circumplex model of emotions.