bluuebunny/crossref_metadata_2025 huggingface dataset:
Understanding the role of veterinarians in antimicrobial stewardship on Canadian dairy farms: A mixed-methods study
Authors: Cobo-Angel Claudia , Roche Steven M. , LeBlanc Stephen J.
Published: July 2023

The aim of this study was to describe the factors that influence dairy cattle veterinarians´ antimicrobial prescribing, their attitudes toward reducing antimicrobial use (AMU) in the dairy industry, awareness of antimicrobial resistance (AMR), and perceived barriers to improving antimicrobial stewardship (AMS) on Canadian dairy farms. We used quantitative and qualitative research methods to consider the complexity of the antimicrobial prescription decision-making process. We designed and distributed an online survey, followed by four online focus groups with practicing veterinarians. We used frequency tables and unconditional associations to analyze quantitative data, and thematic analysis to analyze qualitative data. In total, 107 participants from four Canadian provinces responded to the survey, and 26 veterinarians participated in the focus groups. Results from both studies were triangulated to draw our key findings. We found that 1) Veterinarians must weigh numerous intra-personal and contextual considerations that could be conflicting in their decision-making process for prescribing antimicrobials. 2) Although less experienced veterinarians showed greater awareness of AMR and motivation to improve AMS than more experienced veterinarians, they also reported feeling more pressure to adapt their prescribing practices to farmers’ wishes than more experienced veterinarians. 3) Some veterinarians experienced conflict between prescribing antimicrobials to maintain animal health, productivity, and welfare, and AMS, which could result in blaming others for inappropriate antimicrobial use and reducing the opportunity to critically review their own prescribing practices. 4) There were strategies and barriers in common between veterinarians and farmers such as collaborative reviews of disease treatment protocols and improving preventive medicine on dairy farms. 5) The main barriers to reducing AMU on dairy farms reported by veterinarians were concerns about animal welfare and AMU on dairy farms without consultation with the veterinarian. Our results can inform the development of AMS programs in the Canadian dairy industry.
Immunopeptidome profiling of human coronavirus OC43-infected cells identifies CD4 T-cell epitopes specific to seasonal coronaviruses or cross-reactive with SARS-CoV-2
Authors: Becerra-Artiles Aniuska , Nanaware Padma P. , Muneeruddin Khaja , Weaver Grant C. , Shaffer Scott A. , Calvo-Calle J. Mauricio , Stern Lawrence J.
Published: July 2023

Seasonal “common-cold” human coronaviruses are widely spread throughout the world and are mainly associated with mild upper respiratory tract infections. The emergence of highly pathogenic coronaviruses MERS-CoV, SARS-CoV, and most recently SARS-CoV-2 has prompted increased attention to coronavirus biology and immunopathology, but the T-cell response to seasonal coronaviruses remains largely uncharacterized. Here we report the repertoire of viral peptides that are naturally processed and presented upon infection of a model cell line with seasonal coronavirus OC43. We identified MHC-bound peptides derived from each of the viral structural proteins (spike, nucleoprotein, hemagglutinin-esterase, membrane, and envelope) as well as non-structural proteins nsp3, nsp5, nsp6, and nsp12. Eighty MHC-II bound peptides corresponding to 14 distinct OC43-derived epitopes were identified, including many at very high abundance within the overall MHC-II peptidome. Fewer and less abundant MHC-I bound OC43-derived peptides were observed, possibly due to MHC-I downregulation induced by OC43 infection. The MHC-II peptides elicited low-abundance recall T-cell responses in most donors tested. In vitro assays confirmed that the peptides were recognized by CD4+ T cells and identified the presenting HLA alleles. T-cell responses cross-reactive between OC43, SARS-CoV-2, and the other seasonal coronaviruses were confirmed in samples of peripheral blood and peptide-expanded T-cell lines. Among the validated epitopes, spike protein S903-917 presented by DPA1*01:03/DPB1*04:01 and S1085-1099 presented by DRB1*15:01 shared substantial homology to other human coronaviruses, including SARS-CoV-2, and were targeted by cross-reactive CD4 T cells. Nucleoprotein N54-68 and hemagglutinin-esterase HE128-142 presented by DRB1*15:01 and HE259-273 presented by DPA1*01:03/DPB1*04:01 are immunodominant epitopes with low coronavirus homology that are not cross-reactive with SARS-CoV-2. Overall, the set of naturally processed and presented OC43 epitopes comprise both OC43-specific and human coronavirus cross-reactive epitopes, which can be used to follow CD4 T-cell cross-reactivity after infection or vaccination, and to guide selection of epitopes for inclusion in pan-coronavirus vaccines.
Effectiveness of herbal plants on rumen fermentation, methane gas emissions, in vitro nutrient digestibility, and population of protozoa
Authors: Antonius Antonius , Pazla Roni , Putri Ezi Masdia , Negara Windu , Laia Nursanti , Ridla Muhammad , Suharti Sri , Jayanegara Anuraga , Asmairicen Sharli , Marlina Leni , Marta Yoselanda
Published: July 2023

Background and Aim: Herbal plants have the potential to reduce the population of metagonic bacteria and protozoa due to the bioactive compound contained in herbal plants. This study aimed to evaluate the effect of herbal plant supplementation on rumen fermentation characteristics, methane (CH4) gas emissions, in vitro nutrient digestibility, and protozoan populations.

Materials and Methods: This study consisted of two stages. Stage I involved determining the potential of herbal plants to increase total gas production (Orskov and McDonald methods) and reduce the protozoan population (Hristov method). Three potential herbs were selected at this stage and used in Stage II as supplements in the palm kernel cake (PKC)-based diet (30% herbal plants + 70% PKC). Proximate and Van Soest analyses were used to determine the chemical composition. In vitro dry matter digestibility (IVDMD), organic matter (IVOMD), and rumen fermentation characteristics were determined using Theodorous method. Conway microdiffusion was used to determine ammonia concentration (NH3). Gas chromatography was used to determine the total and partial volatile fatty acid production.

Results: The results of the first stage showed that seven herbal plants (Moringa oleifera, Rhodomyrtus tomentosa, Clerodendron serratum, Curcuma longa Linn., Urena lobata, Uncaria, and Parkia timoriana) significantly differed in terms of total gas production (p < 0.05). Herbal plants can increase gas production and reduce protozoan populations. The highest total gas production was observed using P. timoriana, M. oleifera, and C. longa Linn. Moringa oleifera plants were the most effective in lowering protozoa population. In Stage 2, the supplementation of herbal plants in PKC-based-diet significantly increased IVDMD, that was ranged from 56.72% to 65.77%, IVOMD that was ranged from 52.10% to 59.54%, and NH3, that was ranged from 13.20 mM to 17.91 mM. Volatile fatty acid partial and total gas production potential and CH4> gas emissions were also significantly different from those of the control (p < 0.05).

Conclusion: Supplementation of M. oleifera, C. longa Linn., and P. timoriana in ruminant diet effectively increased total gas production, IVDMD percentage, and IVOMD, and reduced CH4 gas emissions and protozoa populations during rumen fermentation.

Keywords: herbal plants, in vitro, methane, protozoa.
Types of autonomous V-final clauses
Authors: Abraham Werner
Published: July 2023

In German (and Dutch), main clauses and dependent clauses differ clearly with respect to form. Main clauses are always V2 and autonomous (with speech act status) while dependent ones are verb-final/VL (V-last) and nonautonomous (without speech act status). This paper is about autonomous clauses with the form of dependent clauses (i.e. VL-form, also captured in the literature under the term insubordinate subordination, coined by Evans, Nicholas. 2007. Insubordination and its uses. In Irina Nikolaeva (ed.), Finiteness: Theoretical and empirical foundations, 366–431. Oxford: Oxford University Press). In the recent literature, it has been argued that in order to explain the occurrence of autonomous dependent clauses in the historical development of German, the introducing main clause fell elliptically leaving behind a dependent form with autonomous status. The present paper argues that this account is false. Dependent forms can exist independently. Since speech act autonomy of dependent forms exists with certain (albeit not all) complementizers, a special account is provided. It is argued that this development typical of modern German, matches with the tendency toward an illocutionary semantics in its own right. Parallels for the latter path of grammaticalization are drawn from several languages other than German. The importance of the concerns for modern generative grammar is a twofold one: first, it provides insights into how independent (autonomous), but formally dependent sentences divide into several kinds of modality that are expressed in the left sentential periphery; and, second, it shows in which ways speaker-perspective is grammaticalized.
Morphosyntax als Beschreibungsgegenstand der frühneuzeitlichen Fremdsprachenlehrwerke
Authors: Hübner Julia , Filatkina Natalia
Published: July 2023

Im Zentrum des Beitrags stehen die sogenannten Fremdsprachenlehrwerke des 15.–17. Jahrhunderts, die bisher nur am Rande Gegenstand sprachhistorischer Untersuchungen waren. Die Lehrwerke vermitteln die Grundlagen mündlichkeitsnaher Konversation in einer Fremdsprache und wurden vornehmlich von Sprachmeistern verfasst, die allerdings keine Gelehrten sind. Aus diesen Besonderheiten ergeben sich Parallelen sowie bedeutsame Unterschiede im Hinblick auf die Vermittlung von Morphologie und Syntax zwischen diesen Quellen und den sprachtheoretischen gelehrten Traktaten. Anhand der Themen Genus und doppelte Verneinung kann gezeigt werden, dass diese Unterschiede vor allem aus der didaktischen Perspektive sowie der Mehrsprachigkeit der Quellen resultieren.
„Ach [...] was wars so dunkel in dem Wolf seinem Leib!“
Authors: Lindner-Bornemann Bettina , Blombach Andreas
Published: July 2023

Obwohl sich possessive Dative in fast allen deutschen Dialekten, in den regionalen Umgangssprachen sowie im gesprochenen und geschriebenen Substandard finden, spielen sie insgesamt in den bisher erschienenen Arbeiten zu possessiven Ausdrucksformen des Deutschen eine untergeordnete Rolle. In der Forschung stehen recht unterschiedliche Positionen zu Alter (schon im Ahd., erst im Mhd. oder erst im 15. Jh.), Entstehung (Reanalyse zweier ursprünglich unabhängiger Satzglieder oder Analogiebildung zum possessiven Genitiv) und Gebrauch nebeneinander. Der Beitrag überprüft diese Positionen auf der Basis von 7566 manuell annotierten Belegen aus dem DTA-Korpus. Es zeigt sich, dass possessive Dative über den gesamten Zeitraum selten sind; Belege mit possessiver Lesart finden sich v. a. im 16. und 17. Jahrhundert. Die Daten lassen den von den meisten Untersuchungen favorisierten Reanalyse-Ansatz wahrscheinlicher erscheinen, wie ihn bereits Hermann Paul und Otto Behaghel formulierten. Genitive mit Possessivpronomen sind den possessiven Dativen aber zahlenmäßig überlegen und stellen über fast den gesamten Zeitraum eine funktional sehr ähnliche Konkurrenzform dar.
Discovering NDM-1 inhibitors using molecular substructure embeddings representations
Authors: Papastergiou Thomas , Azé Jérôme , Bringay Sandra , Louet Maxime , Poncelet Pascal , Rosales-Hurtado Miyanou , Vo-Hoang Yen , Licznar-Fajardo Patricia , Docquier Jean-Denis , Gavara Laurent
Published: July 2023

NDM-1 (New-Delhi-Metallo-β-lactamase-1) is an enzyme developed by bacteria that is implicated in bacteria resistance to almost all known antibiotics. In this study, we deliver a new, curated NDM-1 bioactivities database, along with a set of unifying rules for managing different activity properties and inconsistencies. We define the activity classification problem in terms of Multiple Instance Learning, employing embeddings corresponding to molecular substructures and present an ensemble ranking and classification framework, relaying on a k-fold Cross Validation method employing a per fold hyper-parameter optimization procedure, showing promising generalization ability. The MIL paradigm displayed an improvement up to 45.7 %, in terms of Balanced Accuracy, in comparison to the classical Machine Learning paradigm. Moreover, we investigate different compact molecular representations, based on atomic or bi-atomic substructures. Finally, we scanned the Drugbank for strongly active compounds and we present the top-15 ranked compounds.
Investigation of channel state information conditions in VL-NOMA using power allocation technique for 6G network
Authors: Ngene Chidi E. , Thakur Prabhat , Singh Ghanshyam
Published: July 2023

This paper investigates the channel state information (CSI) conditions in visible light non-orthogonal multiple access (VL-NOMA) using the power allocation technique (PA) for a sixth-generation (6G) network. One light-emitting diode (LED) is used as a carrier to transmit the signal to three-user-positioned at certain distances. The challenge of allocating power to the system is solved using the PA technique. The PA technique uses to assign signal powers to the three users. The VL-NOMA channel with CSI symbols is synchronized for the performance of signal propagation. We deployed perfect CSI, imperfect CSI, and partial CSI to coordinate the signal enhancement that results in an improved data rate, higher channel capacity, and improved signal-to-noise ratio (SNR). The synchronized system model guarantees successful signal enhancement where perfect CSI performs better than partial CSI and imperfect CSI. We have enabled interference plus noise to see how the system behaves. We notice low channel capacity region, low data rate performance, etc. Hence, we analyse the PA to determine the outage probability effect on the signal.
Artificial intelligence in theranostics of gastric cancer, a review
Authors: Zha Yiqian , Xue Cuili , Liu Yanlei , Ni Jian , De La Fuente Jesus M. , Cui Daxiang
Published: July 2023

Gastric cancer (GC) is one of the commonest cancers with high morbidity and mortality in the world. How to realize precise diagnosis and therapy of GC owns great clinical requirement. In recent years, artificial intelligence (AI) has been actively explored to apply to early diagnosis and treatment and prognosis of gastric carcinoma. Herein, we review recent advance of AI in early screening, diagnosis, therapy and prognosis of stomach carcinoma. Especially AI combined with breath screening early GC system improved 97.4 % of early GC diagnosis ratio, AI model on stomach cancer diagnosis system of saliva biomarkers obtained an overall accuracy of 97.18 %, specificity of 97.44 %, and sensitivity of 96.88 %. We also discuss concept, issues, approaches and challenges of AI applied in stomach cancer. This review provides a comprehensive view and roadmap for readers working in this field, with the aim of pushing application of AI in theranostics of stomach cancer to increase the early discovery ratio and curative ratio of GC patients.
Calibration of photoelastic materials with the disc under diametral compression
Authors: Solaguren-Beascoa Fernández Manuel
Published: July 2023

The disc under diametral compression is one of the preferred specimens for the calibration of photoelastic materials. Current calibration methods have some limitations from a metrological point of view, because they do not provide measurement uncertainties and they assume that observations are independent and with the same accuracy. In this work, a new calibration method is proposed to avoid the above-mentioned metrological limitations: The generalized least squares by Lagrange multipliers method. This methodology accepts correlated input quantities or with different accuracy through the input covariance matrix, and it provides, through a least-squares adjustment, the estimates of the quantities to be measured and their associated standard uncertainties. The application of the method shows coherent results and it also provides a chi-square value that can be used to test the consistency of the measurement model, and the normalized deviations between the input estimates and their fitted values, which are a tool to identify potential outliers. Results reveal a great influence of the radius of the specimen on the uncertainty of the stress-optic coefficient measurement, which casts serious doubt on previous affirmations about the disc in compression is preferable over other specimens.
Electrostatic-spinning construction of HCNTs@Ti3C2T
x
MXenes hybrid aerogel microspheres for tunable microwave absorption
Authors: Li Ying , Guo Siren , Li Yudi , Wu Kaiyou , Zhao Linlin , Liu Xi , Yang Xulin , Wang Pan , Yang Yuxin , Sun Yan , Mou Zihao
Published: July 2023

Helical carbon nanotubes (HCNTs) are chiral materials that can form an induced magnetic field when current passes through them, making them a desirable material for absorbing microwaves. However, poor electrical properties and inert surfaces limit the application of HCNTs as sole materials. In this study, we develop HCNTs@Ti3C2T
x
MXenes hybrid aerogel microspheres synthesized using an electrospinning-assisted ice template method. The modified surfaces of the HCNTs form hydrogen bonds with Ti3C2T
x
MXenes to produce hybrid aerogel microspheres. Because of the different functionalized surfaces of HCNTs (F-HCNTs), F-HCNTs@Ti3C2T
x
MXenes could be adjusted to obtain effective reflection loss (RL) of microwaves ranging from 2 to 18 GHz. The observed advantageous RL is attributed to the modified surface of the HCNTs, their porous structure, and the optimized impedance matching derived from the synergistic effect between HCNTs and Ti3C2T
x
MXenes. Successful assembly method for the 3D architectures of HCNTs@Ti3C2T
x
MXenes hybrid aerogel microspheres significantly widens the practical applications of HCNTs in microwave absorption.
Música y derechos humanos 197 notas por memoria, verdad y justicia en Uruguay
Authors: Cannarozzo Verónica , Krikorian Marcelo
Published: July 2023

This work arises after knowing and listening to “Where are they?” by Luciano Supervielle, Uruguayan musician, composer and producer. The work –composed in 2021 for the March of Silence that takes place on May 20, the date on which the Uruguayan people commemorate the victims of state terrorism, repudiate human rights violations and demand for memory, truth and justice – is made up of a melody of 197 notes that represent the people who are still missing today. The article takes a historical-political journey about the situation in Uruguay after the end of the dictatorship, to inquire about the transitional justice process, the role assumed by the State, the actions promoted by civil society and the actions taken by human rights organizations. For this, regulations and reports from different civil society associations were consulted, and reports and recommendations from various bodies of the international human rights system were studied. Finally, the general characteristics of the work and the author’s statements were analyzed in light of the notion of “The open work” by Umberto Eco (1962) and the main concepts of art as activism (Expósito et al., 2011; Capasso and Bugnone, 2019).
Un sendero siempre necesario en la tutela de los derechos humanos: Los pronunciamientos de la Corte Interamericana en los casos de pena de muerte y desaparición forzada de personas
Authors: Reca Joaquín Pablo
Published: July 2023

This article examines substantial aspects that, with the deployment of advisory and contentious functions by the Inter-American Court of Human Rights, are sculpted within the Inter-American Human Rights System. The purpose of this work is to demonstrate, through the analysis of various pronouncements that essentially concern the death penalty, the forced disappearance of persons and its reparation phase, how the Inter-American Court has been delineating increasingly precise parameters in those matters that, by compelling States to comply with their regional obligations, contribute to greater protection of human rights. For this, we will focus this study from a quantitative perspective, which will allow us, through selected cases of the Inter-American Court, to arrive on its main conclusions.
Pecularities of treatment of elderly patients with type 2 diabetes mellitus
Authors: Demidova T. Yu. , Kochina A. S.
Published: July 2023

The management of diabetes in the elderly requires careful consideration of concomitant geriatric syndromes and chronic diseases that increase the risk of complications, including severe hypoglycemia. An individualized approach to the treatment of elderly patients includes the establishment of less strict goals of glycemic control, blood pressure control, taking into account impaired self-care abilities, cognitive abilities and loss of vision. The goals of diabetes treatment in the elderly are considered to maintain the quality of life and minimize symptomatic hyperglycemia, the risk of hypoglycemia and side effects of medications. In this regard, the concept of deprescribing in the treatment of elderly patients is gaining more and more popularity.
Prediabetes: a risk factor for cardiovascular diseases and a window of opportunity for their prevention
Authors: Demidova T. Yu. , Plakhotnyaya V. M.
Published: July 2023

It’s well known, that diabetes mellitus predisposes to more rapid development and progression of cardiovascular disease (CVD) and cardiomyopathy. However, the pathological changes underlying them begin to form much earlier — at the stage of prediabetes. Individuals with prediabetes have a higher risk of atherosclerosis and chronic heart failure, as well as increased rates of mortality from CVD and all-cause death. This review is devoted to the analysis of pathophysiological mechanisms that lead to developing CVD in patients with early prediabetes. In addition, the article highlights the issues of preventing the development of cardiovascular pathology in this group of patients with an emphasis on the active impact on the main factors of cardiovascular risk.
In the Footsteps of Aeneas: Movement and Narrative in Fourth Century Romano-British Mosaics
Authors: Berlin Nicole
Published: July 2023

Two fourth century Romano-British villa owners commissioned mosaics that draw upon Vergil’s first century BC epic, the Aeneid. The pavements at Lullingstone and Low Ham have been interpreted as evidence of erudite villa owners demonstrating their knowledge of the Roman classics. An iconographical analysis of these mosaics tells only one part of the story. In this article, I analyze the fourth century AD mosaics at Lullingstone and Low Ham through a phenomenological lens, centering the embodied Roman-era viewer. At Lullingstone, an inscription from the Aeneid in the villa’s main reception hall appeals to the seated, static viewer and makes a social distinction between the owner’s invited guests, who alone have the proper vantage to read it, and anyone else in the room. Meanwhile, scenes from the Aeneid in the frigidarium mosaic at Low Ham indicate the direction a viewer should move through the space, ultimately circumnavigating the room. By applying a sensory framework to these two case studies, I demonstrate the role of narrative in mosaics and how it structured a viewer’s experience of Roman social spaces.
Plasma procurement and processing v1
Authors: not provided hannah.anvari
Published: July 2023

Purpose: This protocol is intended for use in the collection and storage of human plasma in a research setting. The protocol details the collection, processing, and long-term storage for downstream analysis alongside other tissues or samples of interest (i.e. follicular fluid, ovary).
Coastal Environmental DNA Sampling & Gravity Filtration Protocol v2
Authors: M. Shea Meghan
Published: July 2023

This is a protocol for collecting coastal environmental DNA (eDNA) samples and gravity filtering them on site, using a set-up with single-use enteral feeding pouches first described in Curd et al. 2019 (see Appendix S6) and further elaborated in Gold et al. 2021.
Gavage - food supplementation for stalled weight gain in mice v1
Authors: not provided taylor.panczyk
Published: July 2023

In mice, specifically in Ndufs2fl/fl mice, weight gain usually stops above 70 days post injecton with the TH-Cre AAV into SNc. From that point, food supplements should be provided once daily via a gavage of 0.4-0.5 mL Ensure (Ensure original; 9gr protein,220 calories and we use Plastic feeding Tubes 22gax25mm FTP-22-25n from INSTECH mfg 2021-08-17; www.instechlabs.com) as long as mice keep gaining weight. When the second stop of weight gain happens, another daily gavage and 1 mL of subcutaneous saline should be added as necessary care.
A stochastic predator-prey model that depends on the population density of the predator
Authors:   Taras Shevchenko national University of Kyiv, Borysenko O. D. , Borysenko O. V. ,   National Technical University of Ukraine "KPI"
Published: July 2023

The system of stochastic differential equations describing a nonautonomous stochastic density-dependent predator-prey model with Holling-type II functional response disturbed by white noise, centered and non-centered Poisson noises is considered. So, in this model we take into account levels of predator density dependence and jumps, corresponding to the centered and non-centered Poisson measures. The existence and uniqueness theorem for the positive, global (no explosions in the finite time) solution of the considered system is proved. We obtain sufficient conditions of stochastic ultimate boundedness and stochastic permanence in the considered stochastic predator-prey model.
Nonverbal Assessment of Theory of Mind in Children with Down's Syndrome
Authors:   , Snoza Julia C. , Lee Nancy R
Published: July 2023

Children with Down syndrome (DS) show marked differences in their early development when compared to typically developing (TD) peers. Major domains of impairment include intellectual abilities, executive functioning, structural language, and Theory of Mind (ToM). ToM encompasses the ability to conceptualize and understand others' thoughts, emotions, perspectives, and intentions. In TD children, these abilities typically begin to mature around age 4-6, while in children with DS, we see delays in ToM development based on chronological age. Although these delays may be due to core social cognitive challenges, they may also be related to underlying delays in language and executive functioning skills, two domains of cognitive functioning that are heavily relied upon in traditional ToM tests. The present study sought to fill gaps in the literature by using a nonverbal assessment (The Penny Hiding Game (PHG)) to explore relationships between cognitive flexibility, response inhibition, and DS children's ToM performance. 63 participants (n=34 DS, n=29 TD) were included, and analyses were carried out to 1) compare group performance on the PHG, a largely nonverbal ToM assessment tool, and 2) explore the relationship between executive functioning skills (response inhibition and cognitive flexibility) and ToM skills. Results demonstrated a significant impairment on the PHG for the DS group when compared to the younger, developmentally similar TD group [F(1, 60)= 5.60, p= .021, [eta][p]²=.085]. In contrast, no statistically significant associations between the PHG and tasks of inhibition or cognitive flexibility emerged. However, an association of medium effect which approached statistical significance was observed between the PHG and the cognitive flexibility task ([beta]=.364, t=1.98, p=.058), such that stronger PHG performance was associated with stronger cognitive flexibility skills. These findings are discussed within the context of the larger research literature on ToM abilities in DS.
Evaluate the effectiveness of hydrotherapy versus land-based exercises outcome on pain and quality of life among patients with rheumatoid arthritis: triple-blind randomized controlled trial
Authors: Jinjwaria Rajendra Kumar
Published: July 2023

Background: Evaluate the effectiveness of hydrotherapy versus land-based exercise outcomes to decrease pain and improve the quality of life among patients with rheumatoid arthritis.
Methods: Triple-blind, randomized controlled, parallel-group, multiple arm trial was conducted between 29/09/2019 to 30/09/2021 at the Department of PMR, KG University Lucknow India and randomization was done through the SNSOE. Eligible 90 patients suffering from rheumatoid arthritis. The intervention (RJHLERA) was administered in both study groups. NRPS used for pain and RJQOL-22 Scale was used for QoL.
Results: The pre-test results showed all the subject’s average pain scores and quality of life had either poor or neither poor nor good levels of the RJQOL-22 scale. At the post-test, in terms of pain, the hydrotherapy exercise group showed the maximum response with an average pain score of 3.64±1.89, the land-based exercises group showed the next to maximum response with an average pain score of 5.88±1.37 while the control group showed the least response with an average pain score of 7.63±1.41. and in terms of quality of life, the hydrotherapy exercise group showed the maximum response with 67.9% very good, and 21.4% good. The land-based exercises group showed the next to maximum response with 19.2% good while the group the clear control group showed the least response.
Conclusions: Effectiveness of hydrotherapy versus land-based exercises, in comparison to land-based exercises the Hydrotherapy exercises group showed the maximum response to reduce the pain and improve the quality of life among chronic rheumatoid arthritis patients.
Improving the quality of Greek web surveys: adaptation of the checklist for reporting results of internet e-surveys in Greek language
Authors: Vassis K. , Maliousis I. , Spanos S. , Poulis I. A.
Published: July 2023

The use of the internet for surveys and research is becoming increasingly widespread, including in observational research, which employs questionnaires and surveys to study various characteristics in patients, professionals, and institutions in biomedical and primary care research
https://doicode.ru/doifile/lj/98/trnio-06-2023-318.pdf
Authors: Скоромыкина А.С.
Published: July 2023

Как в прошлом, так и в настоящем присутствуют препятствия для выхода на российский рынок. В данной статье выявлены и проранжированы основные барьеры для малого и среднего предпринимательства на российском рынке. В работе систематизированы данные учѐных и исследователей, а также сделаны выводы на основе опроса предпринимателей.
Effect of Feeding Malt Sprouts on Nutrient Utilization and Growth Performance of Beetal Goat Kids
Authors: Chakkaravarthi C.R. , Kaur Jasmine , Grewal R.S. , Singla M.
Published: July 2023

Background: Malting is the controlled germination of cereal grains, typically barley or sorghum, followed by appropriate drying to yield a usable extract. Malt extract from germinated cereal seeds leaves a residue of shoots and roots known as malted sprouts. Methods: Experimental animals (n=20) were equally divided into four groups of five animals each (average body weight 10.75±0.27 kg). C was control group fed conventional concentrate mixture, T1 group fed with concentrate containing 10% malt sprouts, T2 group fed with concentrate containing 20% malt sprouts and T3 group fed with concentrate containing 30% malt sprouts in addition to green fodder for 74 days including an adaptation period of 14 days. The body weight was recorded at fortnightly interval. Metabolic trial of 7 day duration was conducted towards the end of growth study using standard protocol. Result: The DM intake (g/d) in T1 and T2 groups was similar to C group, however, it was lowest(P less than 0.05) in T3 group.The digestibility of nutrients (DM, OM and NDF) was higher (P less than 0.05) in T1 and T2 groups having 10% and 20% malt sprouts in the concentrate mixture than T3 group (30% malt sprouts) while N balance was similar in all the groups.The average final body weight at the end of study and average daily gain (ADG) were highest (P less than 0.05) in T1 group (10% malt sprouts) and FCR was also marginally better in T1 group.
The Role of Ionomycin in the Improvement of in vitro Fertilization and Increasing the Rate of Bovine Embryo Development
Authors: Amran Ramzi A. , Aleissa Mohammed S. , Ghadi Muath G. Al , Ammari Aiman A. , Al-Malahi Nawal M. , Alhimaidi Ahmad R.
Published: July 2023

Background: The utilization of in vitro fertilization (IVF) and in vitro embryo production (IVEP) has increased significantly as an effective tool of assisted reproductive technology. Sperm capacitation is a process of membrane maturation allowing the acrosome reaction to take place. Ionomycin is a calcium ionophore that induces the acrosome reaction by increasing calcium cycling across phospholipid membranes. The aim of this study was to enhance the cleavage rate and development of bovine embryos. Methods: Bovine ovaries were collected from the central slaughter house. Oocytes were obtained from follicles and were let to mature for 24 h. Frozen bull semen thawed in 37°C water and transferred to a discontinuous percoll gradient (Sigma GE17-0891-01). The spermatozoon pellet was separated into four groups after resuspension in bovine in vitro fertilization media (BO-IVF): control without additives; with DMSO and with ionomycin (25 and 50 nM) and kept in an incubator for three hours. The oocytes matured under commonly used media (TCM-199) for 24 h. The mature oocytes were then fertilized for 18-24h. The embryos were cultured in SOF medium until the seventh day to study cleavage rate and blastocyst rate. Result: The results indicated that 50 nM ionomycin supplementation considerably reduced cleavage while DMSO and 25 nM ionomycin supplementation had no effect on cleavage percentage. Moreover, when compared to the other groups, ionomycin at 25 nM significantly increased blastocyst development. In conclusion, the highest rate of blastocyst development was observed in the capacitation medium supplemented with 25 nM ionomycin, apparently due to the importance of calcium and metabolism in spermatozoa for fertilization and embryo development.
Assessing the Impact of Integrated Nutrient Management Practices on Growth and Yield Performance of Direct Seeded Rice in Dystrudepts of Nagaland
Authors: Nakhro Avini-e , Singh P. K. , Gadi Yabi , Achumi Kaiho
Published: July 2023

Background: Indian agriculture continues to be a gamble with monsoon, Direct seeded rice (DSR) can prove to be a promising method technically and economically, which is an achievable alternative to transplanted rice. On the other hand, the soil has become dilapidated of late due to ill-agricultural practices. Therefore, soil fertility and productivity restoration are in dire need, which can be done through integrated nutrient management. Methods: The investigation was conducted to assess the impact of integrated nutrient management on the growth and yield performance of direct seeded rice in dyrtrudepts of Nagaland at the experimental farm of the School of Agricultural Sciences (SAS), Medziphema Campus, Nagaland University, during kharif season of 2019 and 2020. A randomized Block Design with three replications and twelve treatments was applied for the trial. Result: Application of 100% RDF + 2 t FYM ha-1 + PSB (T5) significantly increased the growth parameters, yield attributes, and yield of direct seeded rice which was at parity with T4 (100% RDF + 2 t FYM ha-1) in both the years of cultivation. Therefore, the integrated use of nutrients favored the growth and yield characteristics of direct-seeded rice.
On Farm Testing on Foliar Application of Nutrients and Growth Regulators in Pigeonpea (Cajanus cajan L.)
Authors: Jayalakshmi M. , Babu G. Prasad , Kalyani D. Lakshmi , Chaithanya B.H.
Published: July 2023

Background: Onfarm Testings were conducted to asses effect of TNAU Pulse wonder in pigeonpea variety LRG-52 in ten farmer’s holdings of kurnool district during kharif from 2018-19 to 2020-21. Methods: The experiment consisted of 7 technology options (treatments). T1: consisting recommended dose of fertilizers along with spraying of pulse wonder @ 5 kg ha-1 during flowering and 15 days after 1st spray, T2: 75% RDF + Pulse wonder @ 5 kg ha-1 at flowering, T3: 50% RDF + Pulse wonder 5 kg ha-1 at flowering,T4: 100% RDF+ 2% DAP at flowering and pod formation stage T5: 100% RDF alone (20:50: 0 NPK kg ha-1),T6: Farmers practice ( 30: 60: 10 NPK kg ha-1 ),T7: Control. Data was analyzed using least significant difference in R software. Result: The results revealed that the T1 recorded the highest plant height (130,129,127 cm at flowering stage in 2018-19, 2019-20 and 2020-21 respectively). The lowest flower shedding observed in T1 treatment while it was the highest under T6 in all the three years of the study. Pod yield was the highest in T1 (1889, 1870 and ,1873 kg ha-1 in 2018-19, 2019-2020 and 2020-21 respectively) and the lowest in T7. The average highest benefit cost ratio (4.0) was realized in T1 and lowest in farmers practice (T6). Seed yield was positively correlated with number of flowers plant -1 (r value 0.813, 0.762 and 0.735) and test weight (r value 0.795,0.8 and 0.754) and negatively correlated with flower shedding ( r value -0.788,-0.712 and -0.750) in 2018-19, 2019-20 and 2020-21 years respectively. The final yield of crop is the cumulative effects of growth and yield attributes which manipulate the favorable parameters for higher yields.
Characteristics of parents living apart in Norway: Comparing four residence arrangements
Authors: Morbech Maria , Gustavson Kristin , Holt Tonje
Published: July 2023

Objective: This study investigates differences in characteristics between parents practicing four different residence arrangements by applying a novel categorisation of residence arrangements. Background: The research field on factors associated with shared and sole physical residence is growing. This binary approach may neglect important differentials within these two groups. Method: The sample included 1007 parents from the FamC-study, recruited from family counselling offices across Norway. Mixed effects multinomial regression analyses were used to estimate the likelihood of practicing four residence arrangements (i.e. symmetric shared, asymmetric shared, extended sole and limited sole residence) based on relevant factors (i.e. number and age of children, time since separation, financial difficulties, employment status, new partners, interparental dynamics and mental health). Results: Parents with more and older children, fewer financial difficulties and who separated more recently had higher likelihood of practising symmetric shared residence. Parents with younger children were more likely to practise asymmetric shared residence. Parents with younger and fewer children and who had been separated for longer had higher likelihood of practising extended sole residence. Lastly, parents with fewer children and who had more financial difficulties were more likely to practise limited sole residence. Conclusion: The current findings reveal differences between four residence arrangements when expanding the traditional division between "shared" and "sole" residence, emphasising the importance of using a nuanced differentiation of residence arrangements.
Contribuições do enfoque das capacidades de Martha Nussbaum para a educação contemporânea
Authors: Trevisol Marcio Giusti , Centenaro Júnor Bufon
Published: July 2023

Este ensaio tem como objetivo discutir algumas contribuições do Enfoque das Capacidades proposto pela filósofa norte americana Martha Nussbaum para a educação contemporânea. Compreende-se que a fundamentação filosófica e normativa do referido enfoque, que tem como base um conceito de dignidade humana amparado numa concepção de justiça social básica apresenta desafios pertinentes para o campo educacional diante da necessidade de estabelecer esforços para que o desenvolvimento seja humano e não somente econômico. As conclusões do ensaio afirmam três contribuições principais: i) que a educação seja pensada com metas e objetivos plurais, que possam interagir com as múltiplas capacidades centrais; ii) educação como espaço de desenvolvimento da razão prática, em que os sujeitos tenham à disposição condições de assumir o controle de suas próprias vidas, com autonomia, pensamento crítico e imaginação; e iii), a educação e sua função social, que para além do desenvolvimento individual dos sujeitos, precisa promover a justiça social, a partir da cidadania universal.
Efetividade de um curso online de formação para professores
Authors: Andrade Raíssa Bárbara Nunes Moraes , Zerbini Thaís
Published: July 2023

A educação a distância, utilizada na formação e qualificação de professores, está em constante crescimento e carece de mais estudos. Este estudo objetivou o presente estudo tem como objetivo testar um modelo preditor de efetividade de ações educacionais ofertadas a distância, ou seja, a influência das variáveis Estratégias de Aprendizagem, Suporte à Transferência de Treinamento e Reações aos Procedimentos Instrucionais sobre os indicadores de Efetividade de Treinamento (Impacto do Treinamento em Amplitude, Impacto do Treinamento em Profundidade e Mudança Organizacional). Foram aplicados instrumentos de medida em 793 professores egressos de um curso de formação ofertado pela Rede Estadual de Ensino e posteriormente foram realizadas análises de moderação e mediação. Os achados, baseados nos altos níveis de ajuste dos modelos encontrados, comprovaram o poder explicativo da satisfação com os procedimentos instrucionais, das estratégias de aprendizagem, e do suporte à transferência (material e de pares), para o processo subsequente de aplicação das novas habilidades no trabalho considerando ambos tipos de impacto, além da percepção de mudanças organizacionais advindas do treinamento. Os resultados das análises suprem lacunas de pesquisa e oferecem importantes subsídios à avaliação de programas de TD&E, trazendo avanços teórico-metodológicos e implicações práticas para essa área de estudo e intervenção, especialmente no que concerne ao contexto de investigação.
Simulation of Electronic Waste Reverse Chain for São Paulo Circular Economy: An Artificial Intelligence-Based Approach for Economic and Environmental Optimization
Authors: Neto Geraldo Cardoso de Oliveira , Araujo Sidnei Alves de , Alliprandini Dario Henrique , Flausino Fabio Richard , Amorim Marlene
Published: July 2023

The objective of this study was to apply simulation and computational intelligence techniques using artificial intelligence and genetic algorithm for economic and environmental optimization of the reverse network (manufacturers, waste managers and recyclers in São Paulo, Brazil) of waste electrical and electronic equipment (WEEE) to promote circular economy. For the economic evaluation, the reduction of: fuel, drivers, insurance, depreciation, maintenance and charges was considered and for the environmental evaluation, the environmental impact was measured in the abiotic, biotic, water, land, air and greenhouse gases compartments. It is concluded that the optimized structure of the WEEE reverse chain for São Paulo, Brazil reduced the number of collections, making the most of the cubage. It also generated economic and environmental gains, contributing to the strategic actions of the circular economy. Thus, the proposed simulation allows replication in organizational practice, mainly to meet the 2030 agenda on reducing the carbon footprint generated in transport in large cities. Thus, this study can guide companies on structuring the reverse WEEE chain in São Paulo, Brazil for economic and environmental optimization, a relevant aspect considering the exponential generation of WEEE, requiring the implementation of the national solid waste policy, and subsequently the signature of the electronics sector agreement in São Paulo.
Improvement in Indoor Air Quality in Urban Pakistani Regions by Reducing Particulate Matter Size Concentration
Authors: Haroon Muhammad Usama , Ozarisoy Bertug , Altan Hasim
Published: July 2023

This paper describes the indoor air pollution in urban (Lahore, Faisalabad, Gujranwala, Rawalpindi and Karachi) Pakistani regions while considering the outdoor air and the health and wellbeing of the occupants present indoors. It also aims to assess previous methodological approaches Such as Air Conditioning Systems, used by developed countries to improve air quality to demonstrate the improvements that can be made in air quality in Pakistani urban areas. This research also investigates the causes, concentration and effects of poor air quality in Pakistani urban areas such as particulate matter (PM2.5), carbon oxides (COx), nitrogen oxides (NOx), sulphur oxides (SOx) and volatile organic compounds (VOC’s). The average concentration of these pollutants in Pakistan’s indoor air is, particulate matter (PM): [100 – 250 µg/m3 for PM2.5, 200 – 600 µg/m3 for PM10] 1 – 20 ppm for carbon monoxide (CO), nitrogen oxides (NOx): [50 – 100 µg/m3 for NO2, 20 – 40 µg/m3 for NO], 20 – 50 µg/m3 for sulfur dioxide (SO2), volatile organic compounds (VOCs): 0.1 – 0.5 ppm for formaldehyde, 5 – 10 µg/m3 for benzene and 20 – 30 µg/m3 for toluene. It should be noted that these concentrations can differ depending on the origin of pollution, location, and time of day. The literature review is made up of a combination of descriptive research methods that are used to inform the research background of ambient and indoor air quality, thus the literature review provides a theoretical and methodological background about the air pollution and its improvement in different parts of the world. According to the World Air Quality Index, Pakistan is the third most polluted country in terms of average PM2.5 concentration which is 14.2 times the WHO annual air quality guideline value. As a result, it is suggested that a PM2.5 concentration reduction program be implemented in urban Pakistani regions' indoor air.
Recommended Separation Distances for 1.3 Ammunition and Explosives
Authors: Guymon Clint , Liu Ming , Covino Josephine
Published: July 2023

Separation Distances are used throughout the world to protect people and assets from the potential hazardous effects from propellants, explosives, and pyrotechnics. The current separation distances for Hazard Division (HD) 1.3 substances and articles used in the United States, in some cases, may not adequately protect against the effects from heat flux and debris when those substances and articles are ignited in a confined structure. Multiple tests in such a confined scenario with HD 1.3 substances have shown that the heat flux and debris hazards could result in injury at distances beyond the current specified explosives safety separation distance (ESSD). Herein are recommended ESSD’s for confined as well as unconfined HD 1.3 articles and substances based on the analysis of hundreds of tests. Recommended ESSD’s include a smaller value for unconfined quantities less than 100 kilograms and ESSD’s that are consistent with NATO distances for confined substances and articles.