bluuebunny/crossref_metadata_2025 huggingface dataset:
Pesquisas Paraibanas de Licenciatura em Matemática: o que nos trouxe Ubiratan D’Ambrosio
Authors: Alves Carlos Alex , Costa Claudilene Gomes da , Santana Agnes Liliane Lima Soares de , Santos Laís Cândido dos , Almeida Marilene Silva de
Published: June 2023

Neste artigo analisamos possíveis contribuições de Ubiratan D’Ambrosio para as pesquisas paraibanas na Licenciatura em Matemática, norteados pela interrogação: Que aspectos teórico-metodológicos são observados nas pesquisas paraibanas de Licenciatura em Matemática envolvendo a produção científica do Educador Matemático Ubiratan D’Ambrosio? Os aportes teórico-metodológicos vinculam-se à Educação Matemática e à pesquisa descritiva bibliográfica numa abordagem quanti-qualitativa. Consultamos os repositórios institucionais da UFPB, IFPB, UFCG e UEPB no recorte temporal de 2017 a 2021, observando quais Trabalhos de Conclusão de Curso mencionaram Ubiratan D’Ambrosio. Foram encontradas 228 citações em 59 trabalhos validados, as quais permitem inferir que as contribuições de Ubiratan D’Ambrosio estão concentradas principalmente nos trabalhos desenvolvidos na UFPB e UEPB, Educação Básica/Ensino Superior e em estudos de natureza teórica, vinculadas a temáticas como Etnomatemática, (Educação) Matemática e História da Matemática. Estudos desta natureza permitem sistematizar e memorar o legado de Ubiratan D’Ambrosio e a pesquisa paraibana em Educação Matemática.
Rural tourism accommodation performance in times of COVID-19 pandemic
Authors: Sánchez-Cubo Francisco , Lasso-Dela-Vega Elena , Mondéjar-Jiménez José , García-Pozo Alejandro
Published: June 2023

Two years after the COVID-19 pandemic, its effects on rural tourism remain understudied. This paper aims to study the performance of rural accommodation businesses by assessing their environmental and health attitudes. Data on environmental and health measures and business performance perceptions were collected through a questionnaire completed by 1,794 managers, the largest dataset to date for rural tourism. A PLS-SEM model and Importance- Performance Analysis (IPMA) were run to assess both dimensions towards these businesses’ resilience. The main findings were that (1) environmental dimensions were relegated by COVID-19 ones affecting resilience and (2) the fulfilment of hygiene protocols and measures by guests and businesses were crucial in business resilience. The IPMA also allows informed decision-making by identifying relative importance and performance, supporting the PLS-SEM conclusions. In conclusion, the recent situation might have benefited rural tourism businesses thanks to their resilience and might be a chance to tackle rural tourism seasonality.
Spatial differentiation in contestant success in the district round of the Czech Geography Olympiad in 2021 and 2022
Authors: Trahorsch Petr , Svobodová Hana
Published: June 2023

The aim of the article is to analyse the results of the district round of the Czech Geography Olympiad in 2020/2021 and 2021/2022 with a focus on the spatial differentiation of success in completing the competition’s tasks. This quantitatively oriented study tries to answer the question: In what way are the results of the district round of the Geography Olympiad as a competition for students gifted in geography spatially differentiated? To answer the research question, we analysed the overall results of the 2020/2021 and 2021/2022 competitions, while primarily focusing on the differences in the success rate between regions. The results of the analysis showed significant differences between the regions of Czechia, and within some districts, especially the Plzeň and Pardubice Regions, as well as significant differences between districts. On the other hand, within other regions, for example, the Ústí nad Labem, Karlovy Vary, and Liberec Regions, no statistically significant differences were identified.
Traditional and novel approaches to studying the human thermal environment in urban areas: A critical review of the current state of the art
Authors: Lehnert Michal , Geletič Jan , Jurek Martin
Published: June 2023

Traditional approaches to researching the urban thermal environment focus on identifying the specific manifestations of the local climate and microclimate within urban structures and various types of urban development, and on detecting urban heat islands using meteorological station data, mobile measurements, remote sensing, and (micro)climatic modelling. Nonetheless, current manifestations of climate change and its projections into the future bring the need for the effective climatic adaptation of urban environments. Current research focuses on approaches allowing for a more complex assessment of both the thermal and overall environment of people in towns and cities. This requires numerical modelling in high spatial resolution and large questionnaire surveys. Despite many unanswered theoretical and methodological questions, the approaches to and knowledge of the human urban thermal environment demonstrate growing application potential.
In the garden with Lefebvre and Foucault: The cultivation of taste in spaces of food
Authors: Daněk Petr
Published: June 2023

Research on the conventional food system and alternative food networks has evolved largely in isolation from each other. This paper aims to narrow this gap by using a common theoretical framework to disclose the properties of spaces produced by both types of food systems. The theoretical tools used are Lefebvre’s spatial dialectic and Foucauldian analysis of discipline and governmentality. The results indicate constitutive differences in the nature of both types of spaces: while the conventional food system produces standardized relations and spaces, taking away attention from the food itself to other aspects of its sale and supressing knowledge about food provenance and ways of preparation, the diverse spaces of non-market production are shaped around the quality and “taste” of food. This means that the way out of the crisis-laden conventional food system may lead not only through frugality but also through the cultivation of “taste”, that is, the human interest to eat good food, whose taste includes the knowledge of ecological and social relations and cultures producing the spaces of food.
The admission of Ukrainian refugees from the perspective of municipalities in Czechia
Authors: Jelínková Marie , Ochrana František , Plaček Michal
Published: June 2023

The article deals with the migration of 500,000 Ukrainian refugees to Czechia after the outbreak of the war in Ukraine. The study examines the challenges municipalities had to deal with in connection with the reception of Ukrainian refugees. For this, a primary questionnaire survey, statistical analysis of the obtained data, and analysis of documents were conducted. An original historical-processual and retrograde approach was used to explain the genesis and development of the refugees’ reception. A two-dimensional model (matrix) was developed to find out how municipalities dealt with the reception of refugees. The main contribution of this study is the development of a typology of different approaches of actors in multilevel governance to dealing with the emergent situation and empirically supported conclusions as to how well municipalities have managed to coexist with the newly arrived Ukrainians. The study thus provides a unique insight into what issues municipalities are dealing with and how difficult it is for them to manage this rather unusual situation.
Violent and Unethical Non-Violent Abuse of Faith and Ethnoreligious Sentiments in Southeast Europe: Religious Peace-Building?
Authors: HADŽİĆ Faruk
Published: June 2023

The article presents a theoretical and conceptual examination of religious violent and unethical non-violent behaviors, ethnopolitical and clerical synergism, and religious peace-building capacity. I argue that the phenomenon of religious/ethnic violent and non-violent interchangeability adopted by national political unethical behavior has adverse consequences on the post-Yugoslav social behavior and reconciliation process; religions should be a moral peace-building agency. The multiethnic/multireligious socialist Yugoslav society has been violently transformed into influential ethical and clerical cultures, producing antagonistic ethnonational societies sustaining pastoralism as potent identity manifestations of the social capital. War-period visual violence and emotions influenced violent behavior and policy within the discourse "our vs. their sacred ethnic land," creating an unbearable ease of creating fear and motivating violent antagonism and war crimes. The post-war antagonistic media rhetoric, visual antagonism, and abuse of faith adversely impact peaceful coexistence. Ethnic, religious, ideological, and political contextual factors are challenging to generate in post-conflict, divided Balkan societies. Fear of others, religiously distinct, is a category that's difficult to determine and prevent. Western-Balkan societies possess victimological and political mythical conventions, honoring ethnoreligious war victories, defeats, and agonies, maintaining hostility and revenge discourse. Historically, religions were misused to justify violence and maintain non-violence, unethical sociopolitical order, and negative peace. The ideologies of religious superiority intertwine with intensely dominant national perceptions, so belonging to the Serb, Croat, or Bosniak people is equated with Orthodoxy, Catholicism, or Islam. This entanglement is the groundwork for despondency and a hostile peace climate. Current clerical and ethnopolitical policies lead further away from conflict transformation, directing toward the renewal of monotheistic spirituality, cognition, and violence. Political involvement affects "authentic" religion. We should engage in all-inclusive theological and consensus approaches to demonstrate that religions are peace-building agencies, retrieving and revitalizing authentic morality criteria. Religious sentiments mobilize people more rapidly than other identities.
Conformational and functional regulation of the chicken tumor virus number 10 (CT10) regulator of kinase II (CrkII) adaptor protein by cyclophilin A
Authors: Isakov Noah
Published: June 2023

The Src homology 2 (SH2) and SH3 domain-containing chicken tumor virus number 10 (CT10) regulator of kinase (Crk) adaptor proteins include three cellular members that serve as integral constituents of multiple receptor-linked signal transduction pathways. CrkI and CrkII are products of alternative RNA-splicing which is transcribed from a single gene, while Crk-like (CrkL), which is highly homologous to CrkII, is encoded by a different gene. Thanks to their modular structure, the Crk adaptor proteins can simultaneously interact with activated receptors and a wide range of effector molecules, and orchestrate the assembly of complexes containing enzymes and substrates at the receptor site. They are involved in the regulation of a large number of cellular processes which control cell growth, differentiation, transformation, and apoptosis. Cell activation-dependent tyrosine phosphorylation of CrkII and CrkL serves as a major posttranslational modification mechanism that introduces conformational changes in the proteins by promoting an intramolecular interaction between the phosphotyrosine and the self SH2 domain. The resulting conformational change induces downregulation of CrkII- and CrkL-dependent biological processes. A second type of posttranslational modification mechanism regulates the structure and function of the CrkII adaptor protein by immunophilin-mediated protein isomerization. Two of the most abundant immunophilins in T lymphocytes which function as peptidyl-prolyl cis-trans isomerases (PPIases), namely cyclophilin A (CypA) and FK506-binding proteins (FKBPs), can associate with CrkII and catalyze its reciprocal cis-trans isomerization. This mechanism is of special importance for the regulation of T lymphocyte functions and for T cell-mediated immune responses, since immunophilin inhibitors, such as cyclosporin A (CsA) and FK506, function as immunosuppressive drugs that can prevent allotransplanted graft rejection. The present manuscript focuses on selected functions of Crk adaptor proteins, predominantly in T lymphocytes, and reviews in more detail the current knowledge on the immunophilin-dependent regulation of the structure and function of the CrkII adaptor protein.
Molecular mechanism of electroacupuncture for improving perioperative complications with the guidance of enhanced recovery after surgery
Authors: Mao Yu , Yang Lifang
Published: June 2023

Enhanced recovery after surgery (ERAS) is a recommended surgical strategy at present, the core content is to reduce perioperative stress response and postoperative complications through perioperative multi-mode analgesia and intensive surgery. Electroacupuncture (EA) has been widely used in various clinical applications, and its efficacy and safety have been fully proven. The application of acupuncture in ERAS will have an important impact on rehabilitation research and development. In this review, the molecular mechanism of EA in ERAS are summed up from promoting perioperative efficacy to improving postoperative immune status. The combination of EA and ERAS may better promote the recovery of patients and the development of rehabilitation.
Associations between methamphetamine and alcohol use disorder, suicidal ideation, and lowered quality of life in methamphetamine users
Authors: Jirakran Ketsupar , Maes Michael , Buathong Napakkawat , Kalayasiri Rasmon
Published: June 2023

Aim: There is a strong comorbidity between methamphetamine (MA) and alcohol use whereby MA use may contribute to increased alcohol consumption. This study aims to determine the associations between alcohol drinking and MA-associated behaviors among MA users in relation to mood disorders, suicidal ideation, and health-related quality of life (HR-QoL). Methods: Substance use characteristics were obtained in 106 participants with MA use at a substance abuse treatment center by using the Severity of Dependence Scale (SDS) and the Thai version of the Semi-Structured Assessment for Drug Dependence and Alcoholism (SSADDA). Current alcohol drinking behaviors were estimated using the Substance Outcomes Profile (SOP), which was developed and translated from the Treatment Outcomes Profile, by computing the number of alcohol units x days per month of alcohol use. The Mini-International Neuropsychiatric Interview (M.I.N.I.) was used to estimate lifetime histories of mood disorders and substance abuse and current suicidal ideation. Results: Current suicidal ideation in MA users is to a large extent predicted by the severity of current alcohol and MA use, female gender, and a lifetime history of mood disorders (major depression, dysthymia, and hypo-mania). Moreover, a lifetime history of mood disorders is positively associated with the severity of MA, but not with alcohol use. Partial least squares (PLS) path modeling shows that lowered HR-QoL in MA users is predicted by the SDS score and alcohol dosing (both inversely) and that lifetime diagnoses of mood disorders and MA use (both inversely) and alcohol dependence (positively) have significant effects on HR-QoL which are completely mediated via the SDS score. Conclusions: In MA users, the severity of dependence, and MA and/or alcohol use exert adverse effects on current suicidal ideation and HR-QoL. Mechanistic explanations are given which may explain the inverse associations between the severity of MA and alcohol use in MA abusers.
Artificial intelligence and radiomics in magnetic resonance imaging of rectal cancer: a review
Authors: Di Costanzo Giuseppe , Ascione Raffaele , Ponsiglione Andrea , Tucci Anna Giacoma , Dell’Aversana Serena , Iasiello Francesca , Cavaglià Enrico
Published: June 2023

Rectal cancer (RC) is one of the most common tumours worldwide in both males and females, with significant morbidity and mortality rates, and it accounts for approximately one-third of colorectal cancers (CRCs). Magnetic resonance imaging (MRI) has been demonstrated to be accurate in evaluating the tumour location and stage, mucin content, invasion depth, lymph node (LN) metastasis, extramural vascular invasion (EMVI), and involvement of the mesorectal fascia (MRF). However, these features alone remain insufficient to precisely guide treatment decisions. Therefore, new imaging biomarkers are necessary to define tumour characteristics for staging and restaging patients with RC. During the last decades, RC evaluation via MRI-based radiomics and artificial intelligence (AI) tools has been a research hotspot. The aim of this review was to summarise the achievement of MRI-based radiomics and AI for the evaluation of staging, response to therapy, genotyping, prediction of high-risk factors, and prognosis in the field of RC. Moreover, future challenges and limitations of these tools that need to be solved to favour the transition from academic research to the clinical setting will be discussed.
Liquid biopsy: an examination of platelet RNA obtained from head and neck squamous cell carcinoma patients for predictive molecular tumor markers
Authors: Huber Lisa T. , Kraus Johann M. , Ezić Jasmin , Wanli Amin , Groth Marco , Laban Simon , Hoffmann Thomas K. , Wollenberg Barbara , Kestler Hans A. , Brunner Cornelia
Published: June 2023

Aim: Recently, a tumor cell-platelet interaction was identified in different tumor entities, resulting in a transfer of tumor-derived RNA into platelets, named further “tumor-educated platelets (TEP)”. The present pilot study aims to investigate whether such a tumor-platelet transfer of RNA occurs also in patients suffering from head and neck squamous cell carcinoma (HNSCC).
Methods: Sequencing analysis of RNA derived from platelets of tumor patients (TPs) and healthy donors (HDs) were performed. Subsequently, quantitative reverse transcription-polymerase chain reaction (qRT-PCR) was used for verification of differentially expressed genes in platelets from TPs and HDs in a second cohort of patients and HDs. Data were analyzed by applying bioinformatic tools.
Results: Sequencing of RNA derived from the tumor as well as from platelets of TPs and HDs revealed 426 significantly differentially existing RNA, at which 406 RNA were more and 20 RNA less abundant in platelets from TPs in comparison to that of HDs. In TPs’ platelets, abundantly existing RNA coding for 49 genes were detected, characteristically expressed in epithelial cells and RNA, the products of which are involved in tumor progression. Applying bioinformatic tools and verification on a second TP/HD cohort, collagen type I alpha 1 chain (COL1A1) and zinc finger protein 750 (ZNF750) were identified as the strongest potentially platelet-RNA-sequencing (RNA-seq)-based biomarkers for HNSCC.
Conclusions: These results indicate a transfer of tumor-derived messenger RNA (mRNA) into platelets of HNSCC patients. Therefore, analyses of a patient’s platelet RNA could be an efficient option for liquid biopsy in order to diagnose HNSCC or to monitor tumorigenesis as well as therapeutic responses at any time and in real time.
Continuous enzyme activity assay for high-throughput classification of histone deacetylase 8 inhibitors
Authors: Schweipert Markus , Amurthavasan Anuja , Meyer-Almes Franz-Josef
Published: June 2023

Aim: Human histone deacetylase 8 (KDAC8) is a well-recognized pharmaceutical target in Cornelia de Lange syndrome and different types of cancer, particularly childhood neuroblastoma. Several classes of chemotypes have been identified, which interfere with the enzyme activity of KDAC8. These compounds have been identified under equilibrium or near equilibrium conditions for inhibitor binding to the target enzyme. This study aims for the classification of KDAC8 inhibitors according to the mode of action and identification of most promising lead compounds for drug development.
Methods: A continuous enzyme activity assay is used to monitor inhibition kinetics.
Results: A high-throughput continuous KDAC8 activity assay is developed that provides additional mechanistic information about enzyme inhibition enabling the classification of KDAC8 inhibitors according to their mode of action. Fast reversible inhibitors act as a molecular chaperone and are capable to rescue the enzyme activity of misfolded KDAC8, while covalent inactivators and slow dissociating inhibitors do not preserve KDAC8 activity.
Conclusions: The application of continuous KDAC8 activity assay reveals additional information about the mode of interaction with inhibitors, which can be used to classify KDAC8 inhibitors according to their mode of action. The approach is compatible with the high-throughput screening of compound libraries. Fast reversible inhibitors of KDAC8 act as molecular chaperones and recover enzyme activity from misfolded protein conformations. In contrast, slow-binding inhibitors and covalent inactivators of KDAC8 are not capable to recover enzyme activity.
The Moderating Impact of Major Shareholding of Equity on Operational Performance Efficiency and Firm Value Relationship: The Evidence of the Manufacturing Listed Firms at ASE
Authors: Obeidat Mohammed Ibrahim Sultan , Almomani Mohammad Abdullah , Almomani Tareq Mohammed , Darkel Nadeen (Mohammed Adnan) M. Y)
Published: June 2023

The study objects for determining whether a firm value is affected by the operational efficiency of performance, and to determine whether major shareholding moderates the effect relationship of operational efficiency on firm value. Secondary data covering the period starting from 2011 and ending with 2020, attributed to 28 out of 32 listed manufacturing firms at the Amman Stock Exchange, had been collected and used in the analysis. Five indicators of operational efficiency, as an independent, are taken into consideration in the study, including inventory turnover, receivables turnover, total assets turnover, cash flows from operations, and working capital, whereas Tobin’s Q, is used as an indicator for firm value, as the dependent variable. Major shareholding is represented by those shareholders that are having 5 percent or more of the entire number of shares outstanding and is used as a moderator, while firm size, which is measured using the natural logarithms of total assets, is used as a control variable. Using the multiple and the hierarchal regression methods in data analysis and hypotheses testing, the study shows that operational efficiency of performance has a significant impact on firm value, and it plays a clear role and major shareholding plays a significant moderating role on the effective relationship of operational efficiency on firm value. More investigation of the effects of operational efficiency of additional aspects of performance, on firm value, is strongly recommended.
Factors Affecting Students’ Fake News Identification during COVID-19 in Vietnam: Access from Sociological Study and Application of PLS-SEM Model
Authors: Mai Oanh Lu Thi , Ngoc Hung Le , Huong Tra Pham , Anh Binh Ha , Thanh Thuy Nguyen Thi , Duc Dang Nguyen , Thi Oanh Ho , Dieu Linh Pham , Mai Thuong Ong Thi , Thuy Ha Phan Thi , Thi Phuong Bui
Published: June 2023

This study investigates the ability of Vietnamese students to identify fake news in the context of the COVID-19 pandemic and the factors that affect their performance in this regard. Data were collected from 1161 students at two universities in Vietnam between January and June 2022 using in-depth face-to-face interviews and an online questionnaire survey. Results show that while a majority of students are aware of the importance of verifying information, comparing sources, and identifying news factors, only 32.2% of students can identify fake news. Factors such as interest in fake news, channels of receiving fake news, awareness, attitudes, and behaviors towards fake news play a critical role in students’ ability to recognize fake news. Additionally, the study found that the features of fake news strongly and significantly correlate with the identification of fake news. These findings highlight the need for media literacy education and critical thinking training programs among Vietnamese students to help them navigate the complex information landscape and identify fake news in the face of future pandemics or other events.
Role of The Supreme Court in Legal Dispute Settlement Against Property Certificate Holders With Multiple Certificate Issuance
Authors: Teguh Pri Pambudi
Published: June 2023

There have been 31,228 land-related cases in Indonesia in the last four years. As much as 37 percent of the total is a matter of dispute. This problem is generally due to overlapping business use rights (HGU). The purpose of this research is to examine the legal certainty of land rights that have dual ownership certificates. The research method used in this paper is a qualitative research method with a normative juridical approach. Settlement through the Court, is carried out if the counseling effort stops or it turns out that there is a fundamental problem that needs to be resolved by another authorized agency, such as a court, it is advisable for the person concerned to submit the matter to the Court. In relation to the dual certificates, the Supreme Court (MA) is of the opinion that if there are two or more certificates on the same land, the valid and legally binding certificate is the certificate issued earlier. There are still not many studies that examine the role of the Supreme Court in resolving legal disputes against property rights certificate holders with the issuance of multiple certificates.
Investigation of Resilience among Teachers and in Teacher Education
Authors: Bordás Andrea
Published: June 2023

In recent decades, we have witnessed an increasingly widespread and complex use of the concept of resilience. The aim of the present study is to present a holistic concept of resilience that, thanks to its systems theory basis, can be applied very well in educational sciences, including research on teacher training, the institutional environment of teachers, their well-being at work, professional development, or even in the analysis of practical pedagogical situations. The dynamic interactive model of resilience (Shafi, & Templeton, 2020) allows for the examination of the resilience of learners, teachers and the institution, and even the examination of students, educators and teacher training institutions involved in teacher training. In the second part of the study, we present resilience development programs that have proven to be effective in teacher training and further training (BRiTE, ENTREE), which, with their complexity, are well suited to the dynamic interactive model of resilience discussed above.
Clinical trial: multicentral preventive antibiotics with cystectomy within enhanced recovery after surgery (MACS)
Authors: Беркут Мария , Мамижев Эльдар , Галунова Татьяна , Новик Алексей , Румянцева Дарья , Носов Александр
Published: June 2023

Рак мочевого пузыря (РМП) занимает 10 место в структуре онкологической заболеваемости в мире, ежегодно регистрируется 573000 новых случаев этого заболевания и 213000 случаев смертей [1]. У 25–30 % больных РМП при первичном обращении выявляется опухоль, инвазирующая мышечный слой мочевого пузыря и глубже, где золотым стандартом лечения является радикальная цистэктомия (РЦЭ), ассоциированая с высоким уровнем развития периоперационных и отдаленных осложнений [2].

Цель исследования. Изучить частоту развития инфекционных осложнений в период 30-90 дней после РЦЭ в хирургическом стационаре, работающим по протоколу раннего послеоперационного восстановления пациента (ERAS).
Experience with multitargeted antitumor vaccine in a child with diffuse midline glioma, H3 K27M-mutant
Authors: Кулева Светлана , Борокшинова Ксения , Балдуева Ирина , Нехаева Татьяна , Артемьева Анна , Ефремова Наталья , Емельянова Наталья , Новик Алексей , Новиков Сергей , Гиршович Михаил , Сенчуров Евгений , Гумбатова Эльвира , Хабарова Рина , Михайлова Елена , Семенова Юлия , Сахаутдинов Газиз
Published: June 2023

Диффузная глиома высокой степени злокачественности (high-grade глиома) — наиболее часто встречающаяся высокозлокачественная первичная опухоль головного мозга с крайне агрессивным течением и неблагоприятным прогнозом.

В статье описывается клинический случай 10-летнего ребенка с диффузной срединной глиомой головного мозга с альтерацией в гене H3 K27, которому после стандартного химиолучевого лечения в качестве поддерживающей терапии создан дендритноклеточный вакцинный препарат на основе иммуногенных раковотестикулярных и GD2 антигенов [(CTA+ (cancer-testis antigen) GD2+ (ganglioside)] вакцина). Опухолевый лизат был представлен глиобластомной клеточной культурой с экспрессией GD2 96%. В качестве ростовых и дифференцировочных факторов дендритных клеток, полученных из моноцитов периферической крови, были ГМ-КСФ (гранулоцитарно-макрофагальный колониестимулирующий фактор), ИЛ4 (интерлейкин 4) и ФНОα (фактор некроза опухоли α).

Мультитаргетная иммунотерапия CTA+GD2+ аутологичной ДК-вакциной априори решает эволюционную проблему фенотипической гетерогенности и обладает большей клинической и иммунологической эффективностью в отношении high-grade глиом с их постепенным иммуноредактированием.
Demographic Situation in the Arkhangelsk Oblast: Analysis and Solutions
Authors:   Northern (Arctic) Federal University named after M.V. Lomonosov, Kuznetsova Marina N. , Vasilyeva Anastasia S.
Published: June 2023

The issue of differentiation of socio-economic development indicators is relevant for the regions of the Russian Federation. An important condition for the effective and stable development of territories is a favorable demographic situation. This requires a competent and thoughtful demographic policy that will ensure population reproduction and economic development of the constituent entities of the Russian Federation. The study area is the Arkhangelsk Oblast, partly included in the Arctic zone of the Russian Federation, which is of strategic interest to Russia due to its geopolitical, geo-economic position in the modern world. The aim of the work is to analyze the changes in the qualitative and quantitative composition of the population of the Arkhangelsk Oblast, determined by the processes of fertility, mortality, migration, as well as the socio-economic situation and state policy. To analyze the demographic situation, the paper uses traditional methods of analysis (comparison, relative and average values, graphic method). The paper presents the territorial differentiation of the demographic situation in the regions of the Northwestern Federal Okrug. The information base is national and regional statistical information for the last 10 years. The article discusses the interim results of the implementation of the national project “Demography” in the Arkhangelsk Oblast. The results of the study can be useful for state authorities and local governments that manage the regional development of territories within the framework of the national project “Demography”.
Research by M.V. Lomonosov on the Arctic and the Concept of Creating an Electronic Database “Digital Lomonosov” in Russian and Chinese
Authors:   Changchun University, Wang Jinling
Published: June 2023

Currently, against the background of sanctions from the West, Russia and China should strengthen cooperation in all sectors, especially in scientific research and resource development in the Arctic, as well as in combating problems associated with climate change and the use of the Northern Sea Route to enhance mutually beneficial trade activities between the two countries. The digitalization of Arctic culture should become a paramount branch of cooperation between universities in Russia and China, which cannot be done without considering and disseminating the scientific works of M.V. Lomonosov on the North and the Arctic. In China, Lomonosov was a completely understudied Russian scientist from all sides of his achievements in the sciences. The article gives an overview of M.V. Lomonosov’s contributions to the development of the Russian North and the Arctic, describes the processes of shaping his scientific interests in the study of Arctic spaces, analyzes his main theoretical positions on the phenomenon of Arctic lights and the natural conditions for the development of Arctic spaces, reveals his historical views on the role and importance of mastering the Arctic for the language possession of small peoples in this region against the background of the spread of world civilization and culture, which still has not lost its importance. Moreover, the relevance of creating an electronic database “Digital Lomonosov” in Russian and Chinese in parallel for the development of modern Lomonosov’s science and translation studies on the scientific achievements of Lomonosov in China is considered, the main concept of the Project development and specific stages of digitalization of Lomonosov’s works in two languages by joint efforts of scientists from NArFU and CHU are analyzed.
The Origin of the Russkoust'intsy Ethnic Group and Exploration Work in the Indigirka River Delta
Authors:   Institute for Humanitarian Research and North Indigenous Peoples Problems of the Siberian Branch of the RAS, Strogova Ekaterina A.
Published: June 2023

The origin of the group of Russian Arctic old-timers living in the lower reaches of the Indigirka River in the village of Russkoe Ustye is still a subject of discussions. Despite the official version, the version about their origin from the Novgorod boyars, who allegedly settled in those places already in the 16th century, is being actively promoted. Written sources deny rather than confirm the legend with a complete lack of information. The article substantiates an attempt to verify the legend by means of ethnoarchaeological complexes, for which purpose archaeological prospecting works were carried out in the Indigirka delta in order to find predecessors of the contemporary village Russkoe Ustye and to assess their relevance for research. As a result, it became clear that the Staroe Russkoe Ustye tract could become the main source of archaeological material. Dating can also be attempted on the basis of materials from burials located in the Gulyanka area.
Análisis de las complicaciones del acceso vascular en hemodiálisis. Una revisión sistemática
Authors: Hidalgo-Blanco Miguel Angel , Moreno-Arroyo Carmen , Sánchez-Ortega María Aurelia , Prats-Arimon Marta , Puig-Llobet Montserrat
Published: June 2023

Introducción: El acceso vascular sigue siendo uno de los retos más importantes en todas las unidades de diálisis, por todas las complicaciones derivadas de su uso y el gran impacto en la morbimortalidad del enfermo renal. Los tres tipos de acceso vascular más utilizados son la fístula arteriovenosa nativa, el injerto o fístula arteriovenosa protésica y el catéter venoso central.Objetivo: Analizar y evaluar la situación actual y la incidencia de las complicaciones relacionadas con los diferentes accesos vasculares en hemodiálisis.Metodología: Se realizó una revisión sistemática en las bases de datos PubMed, CINAHL, SCOPUS y SciELO. Se incluyeron todos los artículos originales de menos de 5 años de antigüedad en los que uno de sus objetivos fuera analizar la prevalencia o incidencia de las complicaciones de cualquier acceso vascular en hemodiálisis en población adulta.Resultados: El número de artículos para el análisis fueron 15. De ellos, 14 fueron estudios observacionales y uno, un ensayo clínico multicéntrico. Se analizaron datos demográficos de los pacientes, la prevalencia de complicaciones entre todos los accesos vasculares y la incidencia de complicaciones según fístula nativa/protésica/catéter venoso central.Conclusiones: La fístula arteriovenosa nativa es el acceso vascular de elección ya que tiene tasas de complicaciones muy bajas. De entre ellas, la trombosis, es la complicación con más incidencia. El uso de catéter venoso central todavía es muy habitual, pese a ser el acceso vascular que presenta mayores tasas de complicaciones como las infecciones y la bacteriemia, produciéndose en un 10%-17% de los pacientes portadores.
Análisis de la relación entre la fragilidad y la calidad de vida relacionada con la salud en pacientes en diálisis peritoneal contínua ambulatoria
Authors: Peralta-Flores Melanie Christy , Rodríguez-Zamora Mª Cristina , Amato Dante , Cabrera-Delgado Anna Miriam
Published: June 2023

Introducción: El síndrome de fragilidad en pacientes en diálisis puede deteriorar la calidad de vida relacionada con la salud.Objetivo: Analizar la asociación entre el síndrome de fragilidad y la calidad de vida relacionada con la salud en pacientes en diálisis peritoneal continua ambulatoria.Material y Método: Estudio descriptivo de corte transversal, realizado en la Ciudad de México. La muestra por conveniencia incluyó a 106 pacientes del programa de diálisis peritoneal, de los cuales 62% eran hombres. Se registraron edad, estado civil, ocupación, escolaridad, índice de masa corporal, creatinina y albumina. La calidad de vida relacionada con la salud se evaluó con KDQOL SF-36 y la fragilidad mediante la Batería Corta de Rendimiento Físico (BCRF).Resultados: Las puntuaciones de la BCRF mostraron correlación significativa con ciertas categorías de KDQOL SF-36, como efectos de la enfermedad renal, carga de la enfermedad renal y componente físico. Las puntuaciones de la prueba de velocidad de marcha no se asociaron a ninguna categoría de KDQOL SF-36. Tampoco hubo asociaciones entre las puntuaciones obtenidos en el componente mental de KDQOL SF-36 y los de las pruebas de la BCRF. La calidad de vida relacionada con la salud fue menor en los pacientes con fragilidad, edad avanzada o hipoalbuminemia.Conclusiones: Los pacientes en diálisis peritoneal tienen una alta prevalencia del síndrome de fragilidad y disminución de la calidad de vida. Además, la alta tasa de fragilidad está asociada a peor calidad de vida, especialmente en el rendimiento físico.
Generatividad y autocuidado en personas mayores en diálisis
Authors: Seco-Lozano Luisa , Pinazo-Hernandis Sacramento , Domingo-Moratalla Agustín
Published: June 2023

Introducción: La cantidad de personas mayores en tratamiento crónico de diálisis, ya sea en hemodiálisis o diálisis peritoneal está aumentando considerablemente. Vincular el estudio de la generatividad y autocuidado con el envejecimiento en diálisis propicia una mirada positiva sobre la vejez y la vivencia de la cronicidad en diálisis. Este abordaje ayuda no sólo a promover y facilitar específicamente el autocuidado de las personas mayores en diálisis, sino que visibiliza el impacto positivo que tiene en la sociedad la actitud generativa de las personas mayores.Objetivos: Describir la vivencia del autocuidado en la cronicidad en personas mayores en diálisis. Explorar cómo la generatividad puede influir y dar sentido a la experiencia de vivir con diálisis.Material y Método: Investigación narrativa-biográfica que utiliza el registro de Historias de Vida de las personas investigadas.Resultados: En las Historias de Vida de las personas mayores, la generatividad ha sido practicada en el pasado: cuidado de hijos, de familiares enfermos, estando implicados cívicamente en el cambio político y social y desean preservar ese pasado como un legado generativo. Pero también se expresa en el presente por su voluntad y determinación para el propio autocuidado. La actitud generativa durante esta etapa de vivir con diálisis está enfocada de una forma directa hacia su propio autocuidado.Conclusiones: El autocuidado personal se convierte en un acto generativo que hace que las personas mayores en diálisis afronten las diferentes pérdidas experimentadas durante la vivencia de la cronicidad en diálisis con un sentimiento de autonomía.
Pengembangan Alat Pengukur Cepat Rambat Bunyi Menggunakan Sensor Ultrasonik
Authors: Zulfikar Zulfikar
Published: June 2023

Gelombang bunyi adalah salah satu materi pembelajaran fisika yang dianggap sulit oleh peserta didik. Salah satu penyebab hal tersebut adalah guru fisika hanya mengajar dengan media pembelajaran yang seadanya. Berdasarkan analsis kebutuhan yang telah dilakukan, sebagian besar guru fisika mengajarkan materi gelombang bunyi dengan menggunakan media berupa powerpoint. Penelitian ini bertujuan untuk mengembangkan alat praktikum pengukur cepat rambat bunyi di udara dengan menggunakan sensor ultrasonik. Alat ini menggunakan sensor ultrasonik HC-SR04 sebagai pembangkit gelombang ultrasonik dan menggunakan mikrokontroler arduino sebagai sistem kontrol alat praktikum. Hasil dari pengukuran cepat rambat bunyi menggunakan alat ini adalah 342,9986038 m/s dengan presentase error sebesar 0,004294504%.
Arap Dili Alfabesi Öğretimine Yönelik Yeni Bir Teknik Önerisi: İletişimsel Alfabe Öğretim Tekniği
Authors: KURT Muhammed , KOÇ Celal Turgut
Published: June 2023

Arapçanın yabancı dil olarak öğretimine genellikle harflerin okunuşu, yazılışı ve telaffuzu ile başlanır. Daha sonra harfler birleştirilerek, kelime ve cümle okunuşu ve yazılışı aşamasına geçilir. Dili inşa etme süreci bu noktadan sonra başlar. Bu kritik aşamada öğrenenin yeterli beceriyi elde edememesi durumunda öğrenim süreci boyunca zorluklarla karşılaştığı düşünülmektedir. Bunların yanı sıra öğrencinin ana dilinin alfabesi, öğrendiği yabancı dilin alfabesinden farklı olanlara, yabancı dili, iletişimsel olarak öğretme stratejisi, başlangıç öğretimi aşamasında kullanılamamaktadır. Bu ve benzer durumlar düşünüldüğünde Arapça öğretimine başlanıldığı andan itibaren, öğrencinin söz konusu dilin alfabesini kolay bir şekilde öğrenip, kelime ve cümleleri harekesiz okuyup yazabilecek becerinin öğretici tarafından öğrenciye kolayca kazandırılacağı hissettirilmeli ve öğrencinin özgüven kazanması sağlanmalıdır. Araştırmada öneri olarak sunulmuş olan bu yöntem, bahsedilen ihtiyaçların giderilebilmesi için sınıf içi etkileşimi artırıp, öğrenenleri henüz ilk dersten itibaren sürecin içine üretici olarak katacağı bir yol olarak görülmektedir. Çalışmamızda Arap harfleri öğretiminin klasik sırasıyla ve bir bütün olarak ele alınmasının aksine öğrencinin harf öğrendikçe farklı kelime ve cümleler oluşturabileceği bir planlama yapılmıştır. Öğrenci, öğrendiği her bir harfle yeni bir kelime yazar, okur ve seslendirir. Hemen ardından bu kelimeyi cümle içinde kullanır. Sürecin belirlenen yerlerinde Arapçada sıklıkla kullanılan soru ifadeleri gibi kalıp ifadeler öğretime dâhil edilerek, öğrenenin dili kullanma becerisinin artması sağlanır. Harfler tamamlandığında öğrenenin, Avrupa Birliği Ortak Başvuru Metni çerçevesinde belirtilen A1 düzeyi kazanımlarını daha kısa sürede ve daha etkin bir şekilde edineceği düşünülmektedir. Önerilen bu yöntemle beraber hem kur sistemine hem de hazırlık sınıfları programlarına göre hazırlanan ders süreçlerinin, yaklaşık elli ders saatinin, harfleri yalın olarak öğretme amacıyla harcanmaması, aksine bu belirtilen ders saatlerinin etkin ve etkileşimli bir öğretim sürecine evrilmesi hedeflenmektedir.
Dijital Ebeveynlikte Dini Tutumlar Üzerine Nitel Bir Araştırma
Authors: FERAH Nimet
Published: June 2023

Günümüz dünyasında teknoloji kullanımı ebeveynler için yeni bir sorumluluk alanı ortaya çıkarmıştır. Teknolojinin gelişimiyle birlikte hayatımıza giren dijital medya pek çok alanda olduğu gibi dijital dünyaya doğan çocukları da etkisi altına almıştır. Dijital medya kontrolsüz ve bilinçsiz bir şekilde kullanıldığında bir takım zararlı sonuçlar ortaya çıktığı bilinmektedir. Dijital ebeveynlik, internet ve dijital medya kullanımı konusunda anne babaların çocuklarını korumak, onların gelişimlerini sekteye uğratacak durumlara karşı bilinçli davranmak ve gerekli ebeveyn rollerini üstlenmek şeklinde özetlenebilecek yeni bir kavramsallaştırmadır. Dijital medya kullanımı, yol açtığı sorunlar nedeniyle özellikle ebeveynler ve çocuklar için eğitime ve disipline edilmeye açık bir konudur. Dijital ebeveynlik ile ilgili ülkemizde ve dünyada farklı alanlarda çalışmalar yürütülmektedir. Ancak konunun dini tutum ve davranış yönü din bilimleri pratikleri ile pek irdelenmemiştir. Bu noktada çocukların internet ve dijital medya kullanımı konusunda ebeveynlerin dini tutumlarının araştırılmasına ihtiyaç vardır. Din, özellikle birey ve aile yaşantısına yön verme, biçimlendirme ve anlamlandırma açısından hayattaki en önemli öğelerden birisidir. Çalışma, çocuklarının dijital medya kullanımıyla ilgili anne-babaların dini tutum ve değerlendirmelerini belirlemeyi amaçlamaktadır. Dijital ebeveynlikte dini tutumları incelemeyi hedefleyen bu çalışmada nitel araştırma desenine uygun bir şekilde amaçlı örneklem metodu ile Aralık 2020- Ocak 2023 tarihleri arasında ulaşılan ve Türkiye’nin farklı şehirlerinde yaşayan 12 erkek, 10 kadın, toplam 22 katılımcıya yarı yapılandırılmış sorular yöneltilmiştir. Elde edilen veriler içerik analiz yöntemi ile temalara ayrılarak betimlenmiştir. Sonuçta dijital ebeveynlikte dini açıdan kaygılı, kaderci, bilinçli-kontrollü ve reaksiyoner-yasaklayıcı tarzda davranışların ortaya çıktığı bulgularla ortaya konmuştur. Ayrıca ebeveynlerin özellikle dini hassasiyete sahip olanların çocuklarının internet ve sosyal medya kullanımı konusunda dini endişelere sahip olabildikleri ve buna bağlı olarak davranış ve tutumlarının farklılaşabildiği belirlenmiştir.
Mevlânâ’nın Mesnevî’sinde Gece Sembolü
Authors: ULUPINAR Hamide , GÜRER Betül
Published: June 2023

Zaman, hakikatini keşfetme, anlamlandırma, yönetme gibi pek çok yönleriyle düşünce tarihinin en temel konuları arasında yer almıştır. Gündüzün zıddı olan ve karanlık zaman dilimini anlatan geceye de hem insanın ömrünün yarısını kapsadığı hem de hayatın biyolojik ve manevi boyutlarına etkisi büyük olduğu için insanlık tarafından büyük önem verilmiştir. Gündüz, aydınlık ve meşguliyet zamanı olmasına rağmen Kur’ân-ı Kerîm’de gecenin daha fazla zikredildiği, Allah’ın üzerine yemin ettiği vakit ve bir âyeti olarak telakki edildiği görülmüştür. Âyetlerde gece, “dinlenme, peygamberlere vahiy inme, helak, hikmetli işlerin diğerlerinden ayrılma vakti, gizlenme, ibadet etme ve yürüme/yola çıkma vakitleri” şeklinde gerçek anlamda, “karanlık”, “gaflet” ve “örtü” manalarında ise mecaz anlamda kullanılmıştır. Bu çalışmanın amacı, gece kavramının Mevlânâ’nın Mesnevî’sinde kazandığı sembolik anlamları tespit etmekle birlikte kavramın İslâmî gelenekteki ve tasavvuf kültüründeki yerini ortaya koymaktır. Gece, akademik çalışmalara gerektiği ölçüde konu edilmemiştir. Gece hakkındaki mevcut çalışmalarda kavramın Kur’ân-ı Kerîm’deki anlamları, gece ile ilgili kavram ve eylemler; mübarek gecelerin fazileti ve hadislerdeki kullanımına yoğunlaştığı görülmektedir. Mevlânâ üzerinde yapılan çalışmalarda ise Mevlânâ’nın sadece rubâîlerinde gece, seyr ü sülûk metodu açısından ele alınmıştır. Dolayısıyla bu çalışma zamanın yarısı olan gecenin, Mevlânâ’nın Mesnevî isimli eserinde kazandığı sembolik anlamları ve bu remizlerin İslâmî gelenekteki yerini tespitteki boşluğu doldurmayı hedeflemektedir. Mevlânâ, Mesnevî’de “gece” kelimesini çoğunlukla gerçek anlamda kullanmıştır. Gece, eylemin olmadığı anı ifade ederken “karanlık/zulmet-i tabiat, gaflet, örtü” gibi olumsuz; insanın hakikate kapı aralamaya çalıştığı eylem anını anlatırken ise “yol almak/yolda olmak/vuslat” sembolleriyle olumlu zamanı ifade etmektedir. Mevlânâ’nın Mesnevî’sinde geceye yüklediği bu anlamlar/semboller ve kullanım şekilleri Kur’ân’daki kullanım ve manadan ilham alınarak zenginleştirilmiş, gecede/anda/kavramda derinleşme ve yolculuk etme gibi remizler yoluyla anlatılmıştır.