bluuebunny/crossref_metadata_2025 huggingface dataset:
Al-Ribhu (Keuntungan) Dan Ketentuannya Dalam Fiqh Islam
Authors: Yusnaidi
Published: August 2022

Al-Ribhu (profit) is a goal that every business actor wants to achieve in carrying out economic activities. In Islam, it does not regulate certain limits on a profit that must be achieved by business actors in carrying out economic activities. Basically every economic activity in Islam is based on Islamic law, so that every economic activity carried out by every business actor cannot be separated from a halal and good process in obtaining profits. In this study, we will discuss Al-Ribhu, analyze existing definitions based on verse arguments and hadith arguments, and put forward some opinions of scholars related to Al-Ribhu in economic activities. This study also discusses the Al-Ribhu law which is in accordance with the Shari'a and the Al-Ribhu law which is not in accordance with the Shari'a in the implementation of economic activities. This study uses a normative analytical research methodology with the type of research that is library research. In Islamic law it allows every business actor to profit from every economic transaction, which of course is obtained in a lawful way, and Islamic law forbids all profits (profits) obtained through fraudulent methods and market exploitation. Shari'a does not limit profits (profits) to a certain amount but is released to market conditions, provided that market conditions are normal and there is no exploitation.
TEORI DAN PENDEKATAN KONSELING SFBT ( SOLUTION FOUSED BRIEF THERAPY) BERBASIS ISLAM
Authors: Rostini Rena
Published: August 2022

Penelitian ini membahas tentang teori SFBT yang dikembangkan dan dievaluasi menjadi bimbingan dan kenseling berbasis islam dalam praktiknya. Hal ini karena masyarakat Indonesia mayoritas beragama islam dan membutuhkan layanan untuk membantu menemukan solusi terbaik dari masalah yang dihadapinya melalui seorang ahli dibidang psikologi. Tujuan dari bimbingan dan konseling adalah membantu seseorang untuk menemukan solusi dari masalah psikisnya baik dengan pendekatan yang bersifat pencegahan dan pengobatan. Melalui bimbingan dan konseling ini Konselor dapat membantu individu untuk menangani berbagai masalah antara lain masalah pendidikan, keluarga, sekolah dan masyarakat. Penelitian ini menggunakan metode studi kepustakaan. Sumber data yang digunakan dalam penelitian ini adalah data sekunder atau data yang diperoleh bukan dari pengamatan langsung tetapi berasal dari hasil peneliti-peneliti terdahulu dan metode pengumpulan data menggunakan metode dokumentasi. Hasil penelitian ini adalah evaluasi dan pengembangan dari teori SFBT menjadi konsep bimbingan, konseling dan praktik SFBT berbasis Islam.
MENINGKATKAN PROFESIONALITAS LULUSAN PROGRAM STUDI BIMBINGAN DAN KONSELING ISLAM
Authors: Jamil Yusuf M.
Published: August 2022

Profesionalitas sebagai suatu keterampilan untuk mampu bertindak secara professional adalah sebuah tuntutan yang wajib dikuasai oleh seseorang lulusan S-1 sesuai dengan bidang kesarjanaannya. Program Studi Bimbingan dan Konseling Islam (BKI) mempunyai tugas dan fungsi menyelenggarakan pendidikan akademik (Sarjana Konseling Islam)  dan sedang berjuang untuk dapat menyelenggarakan pendidikan profesi (Konselor Islam) secara otomatis memiliki kewajiban untuk meningkatkan kualitas lulusannya mencakup kompetensi akademik dan kompetensi profesional sebagai satu keutuhan.  Prodi BKI dalam mengemban tugas ini juga menghadapi tantangan yang bersifat internal mengenai terbatasnya sumber daya tenaga pendidik berkualitas dan linier dengan bidang ilmu yang dikembangkannya. Di samping itu, Prodi BKI juga menghadapi tantangan eksternal di era disrupsi yang amat sukar diprediksi arah perkembangannya. Solusi yang ditawarkan di sini adalah uji kompetensi terhadap para lulusan dengan pendekatan analisis SWOT dan difokuskan ketika mereka hendak memasuki dunia kerja. Kepada para lulusan  diajukan sejumlah pertanyaan yang berkaitan dengan factor kekuatan (S) dan kelemahan (W) yang ada pada dirinya, serta factor peluang (O) dan factor ancaman (T) yang terbentang di hadapan diri mereka. Dengan hasil ujia kompetensi ini diharapkan Pengelola Prodi BKI dapat menyusun strategi pemantapan kekuatan (S) dan memperbesar peluang (O), serta membenahi factor-faktor kelemahan (W) dan mengurangi factor-faktor ancaran/hambatan (T) untuk diterapkan dalam pengelolaan program studi, sekaligus diharapkan para lulusan dapat memasuki dunia kerja sesuai kompetensi akademik dan kompetensi profesionalnya.
DZIKIR DAN UPAYA PEMENUHAN MENTAL-SPIRITUAL DALAM PERSPEKTIF AL-QUR’AN
Authors: Latif Umar
Published: August 2022

Dzikir adalah ikhtiyar sunggu-sungguh mengalihkan kehidupan gagasan,  pikiran dan perhatian dunia menuju tuhan dan akhirat. Dan dzikir mampu memberikan kontrol emosi seseorang dalam menyikapi penyimpangan berpikir dan rasa cemas berlebihan. Dan al-Qur’an mengandung banyak kata dzikir seperti al-Qur’an surat al-Maidah ayat 91, al-Qur’an surat al-Nur ayat 37 dan ayat-ayat lainnya. Oleh karena itu, berDzikir berarti hendak mengaitkan diri untuk berpikir, juga sekaligus membentuk mental rohani ke dalam eskatologi yang sesungguhnya, yakni alam akhirat. Hal yang sama yang secara leksikal dimana konteks dzikir  adalah mengingatnya dalam pikiran yang menuntut adanya kesadaran hati tentang hakikat kutuhanan yang ditumbuhkan dalam diri manusia dan diaplikasikan  dalam kehidupan baik verbal dan perbuatan. Dengan demikian, konsep dzikir  adalah suatu upaya yang sungguh-sungguh untuk menghadirkan peran Tuhan Subhanahu Wata’ala dalam hati dan kehidupan sehari-hari baik ucapan, perkataan dan perbuatan.
Classification of metageosystems using machine learning models
Authors: Yamashkin S.A. , Yamashkin A.A.
Published: August 2022

The authors describe an approach aimed at improving the efficiency of machine learning models in solving the task of classifying metageosystems, which enables overcoming the limitations imposed on the use of convolutional neural network ones. The presented solution is based on the use of superficial fully connected patterns trained on a set of information territorial descriptors to be integrated based on data from different sources. A technique for constructing a complex territorial descriptor, calculated on the basis of satellite imagery data, a digital elevation model and an electronic landscape map, was developed, which makes it possible to achieve classification accuracy comparable to that of convolutional models within a specific task. An advantage of the approach proposed in the article for enhancing the efficiency of machine learning models in solving the task of classifying metageosystems is the stability of the developed solution in the face of labeled data shortage as well as the possibility of reuse in the study of new territorial systems, subject to additional training and fine tuning. The proposed method can be used to solve the task of automated monitoring the changes in the land use structure and geophysical envelope as well as automated validation of digital maps of a significant territorial coverage.
Estimation of surface water bodies dynamics in Lake Ladoga catchment area according to the project Global Surface Water
Authors: Rasulova A.M.
Published: August 2022

The purpose of the work is to study the dynamics of changes in the surface water area in Lake Ladoga catchment and its separate catchments using remote sensing data over a long period time. The processed archives of the Earth’s water surface “Global Surface Water” are considered as the initial information. In the present study the following datasets are used
Spinoza e práticas clínicas em psicologia: algumas considerações
Authors: Teixeira Anelise Lusser
Published: August 2022

This theoretical essay intends to list some questions about the possible Spinoza’s contributions to the understanding of the modes of subjectivation and, consequently, to the clinical practices of Psychology today. Initially, in line with scholars and commentators, the actuality of Spinoza’s work will be placed even nearly four centuries after his death. In explaining the main concepts of the author, it also proposes to draw an introductory panorama, to those interested in a first contact with this work. Due to the innovative and transformative character of his work, it is necessary to explain the set of concepts, since one concept promotes a change in another and so on. In this course, we will highlight the concept of the multitude, which resizes the importance of collective formations of desire, to indicate the ethical and political revolution wrought by its philosophy. With this movement we then come to the heart of his work with the concepts of affection and body, closely related. Finally, we will make a brief reflection on some forms of suffering present in the contemporary, pointing out the particularities of certain aspects of psychology, based on dualisms, to propose intervention strategies guided by Spinozist inspiration.
Formação generalista: a percepção de egressos de Psicologia
Authors: SANTANA F. M. , SOUSA G. A. , RIBEIRO Marcelo S. Souza
Published: August 2022

The formation in Psychology has been the subject of discussions since its regulation as a profession. The present study aimed to identify the perception of graduates of a Psychology undergraduate course at a federal university in the northeast, about the generalist formation, considering your “recent” history with the university expansion in Brazil and the compliance with the National Curricular Guidelines. This is a qualitative study, whose data were obtained through individual semi-structured interviews, with eight graduates psychologists inserted in the labor market. The analysis of the results occurred based on Bardin’s Content Analysis (1977), where it was observed a little assertive understanding about the concept of generalist formation, and a certain difficulty in naming itself as a generalist professional, even though this posture is part of daily practice. Besides that, there were criticisms about the curriculum and the relationship with the teachers. However, a positive evaluation stands out.
Profil Penyelesaian Soal Operasi Hitung Perkalian dan Pembagian Bentuk Aljabar Siswa SMP Negeri 18 Model SPMI Palu
Authors: Afrilia Safira , Sugita Gandung , Rochaminah Sutji
Published: August 2022

Tujuan dari penelitian ini yaitu: mendeskripsikan penyelesaian soal operasi hitung perkalian dan pembagian bentuk aljabar siswa SMP Negeri 18 Model SPMI Palu. Jenis penelitian ini adalah penelitian kualitatif. Subjek dalam penelitian ini adalah 2 siswa yang diambil dari 32 siswa kelas VIIA SMP Negeri 18 Model SPMI Palu. Hasil penelitian ini menunjukkan bahwa penyelesaian siswa berkemampuan matematika tinggi dalam menyelesaikan soal operasi hitung perkalian dan pembagian bentuk aljabar yaitu: (1) ST menuliskan soal yang diberikan, mengubah soal menggunakan sifat distributif sehingga diperoleh hasilnya. Tetapi pada hasil sifat distributif ST tidak menuliskan tanda bilangan dikarenakan lupa menuliskannya. Kemudian melakukan operasi perkalian, menjumlahkan suku-suku yang sejenis dan diperoleh hasil akhirnya, (2) ST menuliskan soal yang diberikan, melakukan operasi pembagian bersusun sehingga diperoleh hasilnya. Penyelesaian siswa berkemampuan matematika rendah dalam menyelesaikan soal operasi hitung perkalian dan pembagian bentuk aljabar yaitu: (1) SR menuliskan kembali soal yang diberikan, mengelompokkan suku sejenis, mengoperasikan suku sejenis sehingga diperoleh hasilnya. Namun SR salah menentukan hasil operasi bilangan bulat. Hal ini disebabkan karena ketidaktelitian SR ketika mengoperasikan, (2) SR menuliskan soal, tidak melakukan operasi pembagian bersusun sehingga diperoleh hasilnya.
Editorial: Aspects on finance, corporate social responsibility and blockchain: How returns, media, the 4th Industrial Revolution, FinTech investments and trade finance react on sustainable development
Authors: Thanasas Georgios L.
Published: August 2022

This issue of “Risk Governance and Control: Financial Markets & Institutions” is published under difficult circumstances, as humanity tries to escape from the COVID-19 pandemic era but faces a new challenge due to Russia’s evasion in Ukraine. As these events unfold, humanity faces economic depression with all its attendant problems. Life both in everyday life and in the business, the world is facing increased prices and declining living standards in countries worldwide.
A kinetic study of biotransformation from valencene to nootkatone in an oscillatory baffled reactor
Authors: Chilmeran Mohamed , Hodges Matthew , Ni Xiong-Wei
Published: August 2022

In this paper we report our kinetic study of an oxidation reaction from
valencene to nootkatone using enzyme in an oscillatory baffled reactor
(OBR). A full kinetic model using the Langmuir-Hinshelwood formalism was
established and applied to the experimental data, allowing reactor
schemes and orders to be confirmed and reaction rate constants to be
extracted. The analysis of reaction rate constants suggests that most of
the reversible reaction steps can be treated as irreversible,
simplifying reaction schemes. The effect of mixing intensity on the
kinetics was also investigated.
WELL DIFFERENTIATED LIPOSARCOMA OF TONGUE: CASE REPORT
Authors: Singh Moushami , Napit Arun , Piya Gunja , Thakur Prabhat , Mohanty Sambit , shinde Sayali , Jain Ekta , Dhakal Hari
Published: August 2022

Liposarcoma (LS) is the most common soft tissue sarcomas ( STSs ) that
arise from embryonic mesenchymal tissue. The appearance of these tumors
in the head and neck region is rare, with the tongue as a preferred
site. Well differentiated liposarcoma is the most common variant among
all.
Is Gold a Hedge and Safe Haven during Political Uncertainties?
Authors: Rasheed Hafsa , Ahmad Habib , Javid Attiya Yasmin
Published: August 2022

Technological advancements not only bolstered almost all activities, but also accelerated the spread of information in blinks. Thus, announcements about market volatilities along with subpar financial instruments’ performance have led investors to search for alternative assets to cope with amplified uncertainties. Investors in politically unstable economies, like Pakistan, are more prone to the risks of uncertainties so require some safe investments. Previously gold has been investigated as a hedge and safe haven during various economic and market conditions but literature lacks investigation of gold during political uncertainties. So by investigating the role of gold as a hedge and safe haven during political uncertainties against sectors of Pakistan Stock Exchange (PSX), the current study not only contributes to literature, but also contributes to the knowledge of Pakistani investors and asset managers that whether they should consider gold as a diversifier or not. The study incorporates daily gold prices (gold bullion Pkr. per Tola), daily stock prices of PSX sectors and political events of Pakistan for a time span of 2009 to 2019. Appling EGARCH with quantile dummies and event dummies, findings indicate that gold acts as a hedge and safe haven against the stock market and most of its sectors in normal as well as politically uncertain situations. Thus, Pakistani investors must consider gold in asset allocation strategies for having an optimal portfolio that can cope with the risk of acute market conditions and political uncertainties. Finings of current study facilitate Pakistani investors, investment advisors and asset managers to make healthy investment decisions and enjoying the benefits of diversification through inclusion of gold in their portfolios.
Liquidity and Cross-Sectional Variation in Stock Returns: An Emerging Market Study
Authors:   Assistant Professor & Chairperson, Finance Department, Patron, Finance Club,      Institute of Business   Administration (IBA), Karachi., Tauseef Sana
Published: August 2022

The study investigates the existence of liquidity premiums and the relationship between liquidity and equity returns in Pakistan. We estimate stock liquidity using three different measures: stock turnover, illiquidity cost following Amihud (2002), and liquidity beta following Pastor and Stambaugh (2003). For the non-financial firms listed on Pakistan Stock Exchange, we conduct asset pricing tests including liquidity factor in addition to the well-known factors of market, size, book-to-market and momentum. We report significant market, size, BM, momentum, and liquidity premiums in Pakistan’s equity market. Further, the relationship between liquidity factor and stock returns is not consistent for the different liquidity measures used. We document a positive relationship between stock turnover and returns; however, a negative relationship between liquidity and returns is confirmed using the Amihud illiquidity cost and Pastor and Stambaugh liquidity beta.
Spatial Autocorrelation of Passive Surface Wave Data for Assessment of an Earth Dam in Brasília, Brazil
Authors: Guedes Victor José Cavalcanti Bezerra , Borges Welitom Rodrigues , Cunha Luciano Soares da , Maciel Susanne Taina Ramalho
Published: August 2022

ABSTRACT. Surface wave methods are commonly applied to engineering problems for S-wave velocity estimations. Conventional active Multichannel Analysis of Surface Waves (MASW) surveys for earth dam assessment suffer from limitations mainly associated to restrict depth of investigation and negative influences of near noise sources. In Brazil, the need to image around noisy sites over 30 m deep, which are non-ideal contexts for traditional active seismic data campaigns, is commonly in demand. We acquired ten minutes of ambient vibration data at the crest of a large earth dam in Brasília, Federal District. The Spatial Autocorrelation (SPAC) method was applied to develop a 2D S-wave model velocity using surface wave generated from passing vehicles on the adjacent road. A maximum depth of 42 m was achieved, and the model presented a S-wave velocity range from 274 m/s up to 713 m/s. The water level, foundation ground and possible low and high anomalous compaction zones were interpreted. Vs30 was found to vary from stiff to very dense soil along the profile, with higher values observed towards the left abutment.Keywords: earth dam; SPAC; MAM; S-wave; ambient noise. Autocorrelação Espacial de Dados Passivos de Ondas de Superfície para Avaliação de uma Barragem de Terra em Brasília, BrasilRESUMO. Métodos de onda de superfície são rotineiramente aplicados a problemas de engenharia para obtenção de estimativas de velocidade da onda S. A realização de levantamentos de Análise Multicanal de Ondas de Superfície (MASW) ativos convencionais para avaliação de barragens de terra sofrem limitações principalmente associadas à profundidade de investigação restrita e às influências negativas de fontes de ruído próximas. No Brasil, ocorre a necessidade de obter resultados em locais ruidosos com mais de 30 m de profundidade, que são contextos não ideais para as campanhas de sísmica ativa tradicionais. Dez minutos de dados de vibração ambiental foram registrados na crista de uma grande barragem de terra em Brasília, Distrito Federal. O método de Autocorrelação Espacial (SPAC) foi aplicado para desenvolver um modelo 2D da velocidade de onda S considerando ondas de superfície geradas a partir do tráfego de veículos na rodovia adjacente. Foi atingida uma profundidade máxima de 42 m e o modelo apresentou uma faixa de velocidade da onda S de 274 m/s a 713 m/s. Foram interpretados o nível freático, terreno de fundação e possíveis zonas anômalas de compactação baixa e mais elevada. Verificou-se que o Vs30 varia de solo rígido a muito denso ao longo do perfil, com valores mais altos observados em direção à ombreira esquerda.Palavras-chave: barragem de terra; SPAC; MAM; onda S; ruído ambiental.
Deregulation and Board Policies: Evidence from Performance and Risk Exposure Measures Used in Bank CEO Turnover Decisions
Authors: Hayes Rachel M. , Tian Xiaoli , Wang Xue
Published: August 2022

We examine the effects of banking deregulation on bank board policies—specifically, whether deregulation affects the performance and risk exposure measures used in bank CEO turnover decisions. Using the staggered adoption of interstate branching as our setting, we find that bank CEO turnover is more (less) sensitive to stock (accounting) performance after deregulation. We also find that deregulation is associated with a higher sensitivity of bank CEO turnover to the idiosyncratic component of tail risk. Moreover, such changes in turnover policies primarily exist in large banks and federally chartered banks, which are best positioned to exploit growth opportunities, and in banks that expand branch operations after deregulation. Our results indicate an increased emphasis on stock performance and tail risk in turnover decisions when growth opportunities are greater in the deregulated environment. The findings provide evidence that the information used in board decisions varies with features of the competitive environment.
Identifying Odds of Bloodstream Infection in Repaired Silastic Central Venous Catheters in a Pediatric Population
Authors: Taroc Ann-Marie , Sullivan Erin
Published: August 2022

Highlights

Background:

Silicone central venous catheters (CVCs) that weaken or rupture are reparable using a commercial repair kit. A literature review exploring bloodstream infections in repaired CVCs identified many findings indicating low or no increased risk of infection. This study aimed to understand pediatric patients’ risk of bloodstream infection with repaired Hickman or Broviac catheters.

Methods:

A matched retrospective case-control study examined central line–associated bloodstream infection (CLABSI) or bacteremia in two separately matched cohorts of patients with silicone-type catheters. Controls were patients with CVCs selected from 2016 to 2019 and were matched to cases based on age group (older or younger than 3 years). Conditional logistic regression models calculated odds ratios (OR), with 95% confidence intervals (CI) representing the odds of a line repair occurring 30 days before an event among cases versus controls.

Results:

In 61 CLABSI cases and 104 controls, the OR of exposure to a line repair was 0.43; 95% CI, 0.05–3.87, P = 0.45. In comparing 49 bacteremia cases to 109 controls, the OR of exposure to a line repair was 6.69; 95% CI, 0.69–8, P = 0.10.

Conclusions:

The frequency of CVC repair was relatively low. Associations between repair and infection were not detected in either cohort; however, odds of line repair exposure appeared to be higher in bacteremia cases (a trend not observed in the CLABSI cohort). More extensive studies examining the demographic and clinical characteristics of the CVC repair population will be critical for improving outcomes.
Trends in Prescribing Preferences for Antidiabetic Medications Among Patients With Type 2 Diabetes in the U.K. With and Without Chronic Kidney Disease, 2006–2020
Authors: Liaw Julia , Harhay Meera , Setoguchi Soko , Gerhard Tobias , Dave Chintan V.
Published: August 2022

OBJECTIVE

To evaluate trends in antidiabetic medication initiation patterns among patients with type 2 diabetes mellitus (T2DM) with and without chronic kidney disease (CKD).

RESEARCH DESIGN AND METHODS

A retrospective cohort study using the UK Clinical Practice Research Datalink (2006–2020) was conducted to evaluate the overall, first-, and second line (after metformin) medication initiation patterns among patients with CKD (n = 38,622) and those without CKD (n = 230,963) who had T2DM.

RESULTS

Relative to other glucose-lowering therapies, metformin initiations declined overall but remained the first-line treatment of choice for both patients with and those without CKD. Sodium-glucose cotransporter-2 (SGLT2i) use increased modestly among patients with CKD, but this increase was more pronounced among patients without CKD; by 2020, patients without CKD, compared with patients with CKD, were three (28.5% vs. 9.4%) and six (46.3% vs. 7.9%) times more likely to initiate SGLT2i overall and as second-line therapy, respectively. Glucagon-like peptide 1 receptor agonist (GLP-1RA) use was minimal regardless of CKD status (<5%), whereas both dipeptidyl peptidase-4 inhibitor (DPP4i) and sulfonylurea use remained high among patients with CKD. For instance, by 2020, and among patients with CKD, DPP4i and sulfonylureas constituted 28.3% and 20.6% of all initiations, and 57.4% and 30.3% of second-line initiations, respectively.

CONCLUSIONS

SGLT2i use increased among patients with T2DM, but this increase was largely driven by patients without CKD. Work is needed to identify barriers associated with the uptake of therapies with proven cardiorenal benefits (e.g., SGLT2i, GLP-1RA) among patients with CKD.
Measurement of Serum N-Glycans in the Assessment of Early Vascular Aging (Arterial Stiffness) in Adults With Type 1 Diabetes
Authors: Llauradó Gemma , Amigó Núria , Fuertes-Martín Rocío , Romero Ana , Cano Albert , Albert Lara , Giménez-Palop Olga , Berlanga Eugenio , Fernández-Veledo Sonia , Correig Xavier , Vendrell Joan , González-Clemente José-Miguel
Published: August 2022

OBJECTIVE

Vascular aging (arterial stiffness [AS]) is an inflammation-linked process that predicts macro- and microvascular complications in adults with type 1 diabetes (T1D). We evaluated the utility of measuring the inflammation-linked N-glycans GlycA and GlycB to assess vascular aging in adults with T1D.

RESEARCH DESIGN AND METHODS

Eighty-four adults with T1D (>10-year duration without cardiovascular events) and 68 healthy control subjects were evaluated for clinical characteristics (including microvascular complications in patients with T1D), aortic pulse wave velocity (aPWV) (surrogate measure of AS), and serum GlycA and GlycB (peak area [concentration] and height/width [H/W] ratio) using 1H-nuclear magnetic resonance spectroscopy.

RESULTS

Patients with T1D had higher median (interquartile range) values than healthy control subjects for (P < 0.001 for all comparisons) aPWV 7.9 (6.9–9.1) vs. 6.1 (5.5–6.7) m/s, GlycA 850.4 (781.3–916.1) vs. 652.4 (581.5–727.1) μmoL; GlycB 386.1 (353.2–426.3) vs. 310.0 (280.5–331.9) μmol/L), H/W ratio of GlycA 16.5 (14.9–18.1) vs. 15.0 (13.7–16.7), and H/W ratio of GlycB 5.0 (4.6–5.5) vs. 4.0 (3.4–4.3). Moreover, aPWV correlated (P < 0.001 for all correlations) with GlycA (r = 0.550) and GlycB (r = 0.423) concentrations and with H/W ratios of GlycA (r = 0.453) and GlycB (r = 0.510). Adjusting for potential confounders, GlycA concentration (β = 0.212, P < 0.001) and the H/W ratios of GlycA (β = 0.150, P = 0.009) and GlycB (β = 0.155, P = 0.011) remained independently associated with aPWV. C-statistics for detecting individuals with aPWV >10 m/s were 0.866 (95% CI 0.794–0.937) for GlycA levels and 0.862 (0.780–0.943) for H/W ratio of GlycB.

CONCLUSIONS

Measurement of serum GlycA and GlycB may have utility in assessing vascular aging in adults with T1D of >10-year duration and no previous cardiovascular events.
Effects of Patient-Driven Lifestyle Modification Using Intermittently Scanned Continuous Glucose Monitoring in Patients With Type 2 Diabetes: Results From the Randomized Open-label PDF Study
Authors: Choe Hun Jee , Rhee Eun-Jung , Won Jong Chul , Park Kyong Soo , Lee Won-Young , Cho Young Min
Published: August 2022

OBJECTIVE

To investigate the effects of patient-driven lifestyle modification using intermittently scanned continuous glucose monitoring (isCGM) in patients with type 2 diabetes (T2D).

RESEARCH DESIGN AND METHODS

We conducted a 12-week, open-label, randomized controlled trial. A total of 126 participants were 1:1 randomized to either the intervention group (structured education + isCGM) or the control group (standard care with blood glucose monitoring). The Self-Evaluation Of Unhealthy foods by Looking at postprandial glucose (SEOUL) algorithm was developed and applied to aid structured education in guiding patients to follow healthy eating behavior depending on the postprandial glycemic response. The primary end point was the change in HbA1c level from baseline.

RESULTS

Implementation of the SEOUL algorithm with isCGM was associated with greater improvement in HbA1c than with standard care (risk-adjusted difference −0.50%, 95% CI −0.74 to −0.26, P < 0.001). Participants in the intervention group had a greater reduction in fasting blood glucose and body weight (−16.5 mg/dL, 95% CI −30.0 to −3.0, P = 0.017; −1.5 kg, 95% CI −2.7 to −0.3, P = 0.013, respectively). The score sum for the Korean version of the revised Summary of Diabetes Self-Care Activities Questionnaire increased in both groups but to a greater extent in the intervention group (mean difference 4.8, 95% CI 1.7–8.0, P = 0.003). No severe hyperglycemia or hypoglycemia was reported in either group of patients.

CONCLUSIONS

Patient-driven lifestyle modification primarily focused on eating behavior using isCGM effectively lowered HbA1c levels in patients with T2D.
Effects of Patient-Driven Lifestyle Modification Using Intermittently Scanned Continuous Glucose Monitoring in Patients with Type 2 Diabetes: Results from the Randomized Open Label PDF Study
Authors: Choe Hun Jee , Rhee Eun-Jung , Won Jong Chul , Park Kyong Soo , Lee Won-Young , Cho Young Min
Published: August 2022

  

OBJECTIVE

To investigate the effects of patient-driven lifestyle modification using intermittently scanned continuous glucose monitoring (isCGM) in patients with type 2 diabetes mellitus (T2D).

RESEARCH DESIGN AND METHODS

We conducted a 12-week, open-label, randomized controlled trial. A total of 126 participants were 1:1 randomized to either the intervention group (structured education + isCGM) or the control group (standard care with blood glucose monitoring). The Self-Evaluation Of Unhealthy foods by Looking at the postprandial glucose (SEOUL) algorithm was developed and applied to aid structured education by guiding patients to follow healthy eating behavior depending on the postprandial glycemic response. The primary endpoint was the change in HbA1c level from baseline.

RESULTS

Implementation of the SEOUL algorithm with isCGM was associated with a greater improvement in HbA1c than standard care (risk-adjusted difference, –0.50%, 95% CI, –0.74 to –0.26%, P < 0.001). Participants in the intervention group had a greater reduction in fasting blood glucose and body weight (−16.5 mg/dL, 95% CI, −30.0 to −3.0 mg/dL, P = 0.017; −1.5 kg, 95% CI, −2.7 to −0.3 kg, P = 0.013, respectively). The score sum for the Korean version of the revised summary of diabetes self-care activities increased in both groups but to a greater extent in the intervention group (mean difference 4.8, 95% CI, 1.7–8.0, P = 0.003). No severe hyperglycemia or hypoglycemia was reported in either group of patients.

CONCLUSIONS

Patient-driven lifestyle modification primarily focused on eating behavior using isCGM effectively lowered HbA1c levels in patients with T2D. 
MACRONUTRIENT RECOMMENDATIONS FOR REMISSION AND PREVENTION OF DIABETES IN ASIAN INDIANS BASED ON A DATA DRIVEN OPTIMIZATION MODEL: THE ICMR-INDIAB NATIONAL STUDY
Authors: Anjana Ranjit Mohan , Srinivasan Seshadhri , Sudha Vasudevan , Joshi Shashank R , Saboo Banshi , Tandon Nikhil , Das Ashok Kumar , Jabbar Puthiyaveettil Kottayam , Madhu Sri Venkata , Gupta Arvind , Bajaj Sarita , Chowdhury Subhankar , Kalra Sanjay , Gayathri Rajagopal , Abirami Kuzhandaivelu , Manasa Valangaiman Sriram , Thamotharan Padmapritha , Lakshmipriya Nagarajan , Geetha Gunasekaran , Deepa Mohan , Pradeepa Rajendra , Unnikrishnan Ranjit , Kurpad Anura Viswanath , Krishnaswamy Kamala , Kaur Tanvir , Dhaliwal Rupinder Singh , Mohan Viswanathan , Group the ICMR– INDIAB Collaborative Study
Published: August 2022

  

Objective: To derive macronutrient recommendations for remission and prevention of type 2 diabetes (T2D) in Asian Indians using a data-driven optimization approach. 

Research Design and Methods: Dietary, behavioral and demographic assessments were performed on 18,090 adults, participating in the nationally representative, population-based ICMR-INDIAB study. Fasting and two-hour post glucose challenge capillary blood glucose and glycosylated haemoglobin (HbA1c) were estimated. With HbA1c as outcome, a linear regression model was first obtained for various glycemic categories [Newly diagnosed diabetes (NDD), pre-diabetes (PD) and normal glucose tolerance (NGT)]. Macronutrient recommendations were formulated as a constrained quadratic programming problem (QPP) so as to compute optimal macronutrient compositions that would reduce the sum of the difference between the estimated HbA1c from the linear regression model and the targets for remission (6.4% for NDD and 5.6% for PD) and prevention of progression (≤ 6.5% for both NDD and PD). 

Results: Four macronutrient recommendations (%E- Energy) emerged for-1) Diabetes remission in NDD: carbohydrate 49-54%, protein 19-20%, fat 21-26%; 2) PD remission to NGT: carbohydrate 50-56%, protein18-20%, fat 21-27%; 3&4) Prevention of progression to T2D in PD and NGT: carbohydrate 54-57% and 56- 60%protein 16-20% and14-17% respectively; fat 20-24% for PD and NGT.

Conclusions: We recommend reduction in carbohydrates (%E) and an increase in protein (%E) for both T2D remission and for prevention of progression to T2D in PD and NGT groups. Our results underline the need for new dietary guidelines that recommend appropriate changes in macronutrient composition for reducing the burden due to diabetes in South Asia. 
The initiation of new glucose lowering therapies may act to reduce physical activity levels: pooled analysis from three randomised trials
Authors: Yates Thomas , Sargeant Jack A , King James A , Henson Joe , Edwardson Charlotte L , Redman Emma , Gulsin Gaurav S, , Brady Emer M , Ahmad Ehtasham , Stensel David J , Webb David R , McCann Gerry P , Khunti Kamlesh , Davies Melanie J
Published: August 2022

  

OBJECTIVE: Sodium-glucose cotransporter 2 inhibitors (SGLT2i) and GLP-1 receptor agonists (GLP-1RA) reduce body weight and improve cardiometabolic health, but their effect on physical activity is unknown.

RESEARCH DESIGN AND METHODS. We pooled data (n = 148) from three randomised trials to investigate the effect of empagliflozin (SGLT2i) and liraglutide (GLP-1RA), in comparison to sitagliptin (dipeptidyl peptidase 4 inhibitor) and dietary therapies on accelerometer-assessed physical activity.

RESULTS: Liraglutide (-1144 steps/day; 95% CI -2069, -220), empagliflozin (-1132 steps/day; -1739, -524) and sitagliptin (-852 steps/day; -1625, -78) resulted in reduced total daily physical activity after 6 months (p< 0.01 vs. control). Moderate-to-vigorous intensity physical activity was also reduced. Dietary interventions led to no change or an increase in physical activity.

CONCLUSIONS: The initiation of all glucose lowering therapies was associated with reduced physical activity, warranting further investigation. 
TBK1-mTOR signaling attenuates obesity-linked hyperglycemia and insulin resistance
Authors: Bodur Cagri , Kazyken Dubek , Huang Kezhen , Tooley Aaron Seth , Cho Kae Won , Barnes Tammy M , Lumeng Carey N , Jr Martin G Myers, , Fingar Diane C
Published: August 2022

The innate immune kinase TBK1 (TANK-binding kinase 1) responds to microbial-derived signals to initiate responses against viral and bacterial pathogens. More recent work implicates TBK1 in metabolism and tumorigenesis. The kinase mTOR (mechanistic target of rapamycin) integrates diverse environmental cues to control fundamental cellular processes. Our prior work demonstrated in cells that TBK1 phosphorylates mTOR (on S2159) to increase mTORC1 and mTORC2 catalytic activity and signaling. Here we investigate a role for TBK1-mTOR signaling in control of glucose metabolism in vivo. We find that diet induced obese (DIO) but not lean mice bearing a whole-body “TBK1 resistant” Mtor S2159A knockin allele (MtorA/A) display exacerbated hyperglycemia and systemic insulin resistance with no change in energy balance. Mechanistically, Mtor S2159A knockin in DIO mice reduces mTORC1 and mTORC2 signaling in response to insulin and innate immune agonists, reduces anti-inflammatory gene expression in adipose tissue, and blunts anti-inflammatory macrophage M2 polarization, phenotypes shared by mice with tissue-specific inactivation of TBK1 or mTOR complexes. Tissues from DIO mice display elevated TBK1 activity and mTOR S2159 phosphorylation relative to lean mice. We propose a model whereby obesity-associated signals increase TBK1 activity and mTOR phosphorylation, which boost mTORC1 and mTORC2 signaling in parallel to the insulin pathway, thereby attenuating insulin resistance to improve glycemic control during diet-induced obesity.
O conflito entre meio ambiente e comércio internacional na OMC como elemento representativo do paradoxo direito natural-direito positivo.
Authors: Miranda Barbosa Nicole
Published: August 2022

Resumo: Este estudo investiga a interação existente entre comércio internacional e meio ambiente no Direito Internacional e busca ilustrar o paradoxo direito natural-direito positivo na OMC por meio das decisões de seu Órgão de Solução de Controvérsias. O presente artigo evidencia como os interesses comerciais têm sido privilegiados em detrimento dos interesses referentes ao meio ambiente.
A due diligence é um padrão para manter os Estados responsáveis pelos seus atos durante a pandemia de covid-19? - o caso brasileiro
Authors: França Nathalia Penha Cardoso de
Published: August 2022

A due diligence é um padrão plástico, varia de acordo com o nível de risco da situação e os atuais recursos técnicos, financeiros e humanos do Estado. No entanto, os Estados são responsáveis por prevenir, mitigar ou mesmo deter um dano grave, como uma pandemia viral, independentemente de sua (falta) infraestrutura de saúde. Para a pandemia COVID-19, investigaremos a possível aplicação de quatro deveres de devida diligência: i) o princípio de não causar danos; ii) o dever de proteger os direitos à saúde e à vida; iii) as obrigações do Regulamento Sanitário Internacional; e iv) a responsabilidade de proteger as vítimas de desastres. O que os Estados devem fazer legalmente para impedir ou mitigar os efeitos da pandemia, bem como para evitar que ela volte no futuro? Os Estados falharam até agora em prevenir ou interromper a propagação da doença, uma vez que souberam de seus riscos? No Brasil, a negação do Governo Federal encorajou a propagação da pandemia e colocou milhões de pessoas em risco. O Estado rejeitou o conselho de funcionários da saúde, demitiu muitos ministros da Saúde, brigou com governadores que tentaram implementar medidas sanitárias, colocou os grupos vulneráveis em maior risco, disse que a vacina não seria obrigatória, e negou 53 e-mails de proposta para comprá-los.
Compliance Tributário e as diretrizes da Organização para a Cooperação e o Desenvolvimento Econômico (OCDE)
Authors: Rodrigues Cristina Barbosa , Rodrigues Cardoso Thamyres
Published: August 2022

O presente artigo tem como objetivo analisar os benefícios e as dificuldades enfrentadas pelas empresas no momento da implementação do compliance tributário, diante do cenário atual no qual encontramos uma grande complexidade no sistema tributário brasileiro. Para tanto, a metodologia que fora utilizada abrange pesquisas bibliográficas, sendo analisado doutrinas jurídicas, artigos, dados estatísticos do Doing Business e IBPT, e também estudos realizados pela Deloitte e PWC, feitas com diversas empresas referente ao compliance tributário, no intuito de verificar as vantagens e desvantagens da implementação desse programa, analisando também os motivos geradores de tais desvantagens.
IMPLEMENTASI OPERASIONAL ZAKAT INFAK DAN SEDEKAH DALAM MEWUJUDKAN KESEJAHTERAAN PERSPEKTIF EKONOMI ISLAM (Studi di Koperasi Simpan Pinjam Pembiayaan Syariah Baitul Maal Wat Tamwil Fajar Metro)
Authors: Darajat Ulfah Alfiyah , Suharto Suharto , Bahrudin Moh.
Published: August 2022

Islam guarantees a distribution of income that contains human values. For example, the guidance to distribute wealth through zakat, infaq, shadaqah (ZIS) and others in order to maintain harmony in social life. ZIS can be used to open work opportunities in the form of capital assistance, educational assistance, health facility assistance and so on, so that later will be more productive. This paper will specifically examine comprehensively the operation of ZIS and its implementation in realizing prosperity in the perspective of Islamic economics at KSPPS BMT Fajar Metro. This is a field research with a qualitative descriptive approach. The data consists of primary and secondary sources which are then collected by interview, observation and documentation methods. Data analysis through data reduction, data display and drawing conclusions and verification. The interesting findings of this study are, first, that ZIS management operations are divided into two, on the collection of funds and their distribution. Sources of funds for the collection of ZIS funds and other religious social funds. Second, the operational implementation of ZIS in realizing the welfare of society from an Islamic economic perspective can be seen from two aspects, namely according to the Qur'an and hadith as well as Islamic economists.Keywords: Zakat, Infaq, Alms, Welfare, Islamic Economics
KEMISKINAN DAN PERILAKU KEAGAMAAN DALAM MENGUNGKAP SIMBOL KEAGAMAAN PENGEMIS
Authors: Suhandi Suhandi , Erlita Dewi
Published: August 2022

Poverty is a social problem that is always present in the midst of society, and has always been a very interesting topic for discussion and study of the development of human life from time to time. In addition to displaying impressions such as pleading facial expressions to attract the sympathy of buyers and market traders, religious symbols are often used as attributes of begging such as caps, headscarves, and prayers. This paper will discuss the factors that make beggars a livelihood, and look further at the work of begging for their religious behavior. This study uses a qualitative descriptive method, with the type of field research and a case study research design. Data collection uses three techniques, namely: observation, interviews, and documentation. Data analyisis through data reduction, data display, and conclusion drawing / verification. The results of the study indicate that someone does something caused by various factors such as physical disability, low education level, lack of skills, friends, and the assumption that begging is a lawful job. The influence of begging activities on the behavior of religious beggars such as prayer, fasting, and zakat implementation, although in the practice of begging they often use religious symbols such as hats, headscarves, reading prayers, but in their lives they do not actually carry out their behavior in accordance with the teachings of their religion, symbols The religious symbols used will display the figure of a religious beggar, which is used as a sympathy puller to get people's sympathy.Keywords: Religious Behavior, Religious Symbol, Beggars
VALIDITAS HADIS-HADIS PADA BUKU “MATERI KHOTBAH JUMAT SETAHUN” KARYA AHMAD YANI
Authors: Muhammad Zaki
Published: August 2022

Many books about religious sermon for Jumat prayer contain many hadiths and are popular among khatib (preachers). Ideally, the hadiths derive from standard books of hadith written by recognised imams. However, some authors incorporating hadiths into the religious sermon books neglect therules of hadith quotation. They include hadith without attaching hadith resources (transmitters). As a result, the hadiths doubtful in terms of authenticity and validity. As the religious sermon books become vouge among khatib (preachers), many khatibs uncritically quote the hadiths and deliver them to jamaah during Jumat prayer. This paper aims to examine the method of the hadiths incorporation and their authenticity in the religious sermon book of Materi Khotbah Jumat Setahun written by Ahmad Yani. This book is selected as it becomes vogue among khatib (preachers). This study constitutes library research employing hadith science approach as data analysis. The findings of this study are presented descriptively and qualitatively. This paper finds that firtsly, the writer of the book partly comply with the methods of hadith quotation as required by ilmu hadith (the prophet tradition science). Secondly, the authenticity of the hadith the author quotes varies from shahîh, hasan, dhaîf, and laysa bihadith. However, the hadith that shahîh (authentic) outnumbers the others, i.e. 34 out 49 hadiths examined are authentic (69%). This paper recommends that the book of Materi Khotbah Jumat Setahun is appropriate for khatib guidance in delivering religious sermon for Jumat prayer.Keywords: Authenticity, Hadith, Khotbah
Hubungan Antara Keterampilan Berkomunikasi dengan Hasil Belajar IPS pada Peserta Didik Kelas V SD
Authors: Ningrum Ayu Reza , Putri Nungky Kurnia
Published: August 2022

Keterampilan berkomunikasi sangat dibutuhkan untuk mencapai keberhasilan belajar peserta didik. Memiliki keterampilan berkomunikasi akan menjadikan peserta didik untuk lebih mudah dalam mengkomunikasikan berbagai macam hal yang berkaitan dengan pembelajaran. Keterampilan berkomunikasi baik secara lisan maupun tulisan dapat mempengaruhi hasil belajar siswa. Tujuan dalam penelitian ini adalah untuk mengetahui apakah terdapat hubungan antara keterampilan berkomunikasi dengan hasil belajar pada mata pelajaran Ilmu Pengetahuan Sosial (IPS) pada peserta didik kelas V SDN 2 Perumnas Way Kandis Bandar Lampung. Penelitian ini menggunakan metode kuantitatif dengan pendekatan analisis deskriptif korelasi. Populasi dalam penelitian ini adalah peserta didik kelas VA dan VB SDN 2 Perumnas Way Kandis TA. 2019/2020 dengan jumlah 65 orang peserta didik. Pengambilan sampel dalam penelitian ini  menggunakan teknik purposive sampling, sehingga sampel dalam penelitian ini adalah 30 peserta didik di kelas VA. Teknik pengumupulan data dalam penelitian ini diantaranya studi pustaka, observasi dan dokumentasi. Teknik analisis data dalam penelitian ini menggunakan uji statistik dengan rumus pearson product moment. Hasil penelitian menunjukan terdapat hubungan yang signifikan antara keterampilan berkomunikasi dengan hasil belajar pada peserta didik kelas V SDN 2 Perumnas Way Kandis Kota Bandar Lampung TA. 2019/2020 dengan indeks interpretasi kuat dengan nilai rhitung sebesar 0,771 yang lebih besar dari nilai rtabel 0,361 atau 0,7710,361, lalu nilai thitung sebesar 6,404 dimana lebih besar dari ttabel 2,048. Kemudian, nilai signifikansinya lebih kecil dari 0,05 yaitu 0,0000,05. Derajat korelasi anatara X dan Y didapati pada rentang 0,61 sampai dengan 0,80. Keterampilan berkomunikasi mempengaruhi sebesar 59,4% terhadap hasil belajar peserta didik dalam mata pelajaran IPS.