bluuebunny/crossref_metadata_2025 huggingface dataset:
Perceived Stress, Resilience, and Wellbeing in Seasoned Isha Yoga Practitioners Compared to Matched Controls During the COVID-19 Pandemic
Authors: Upadhyay Preeti , Narayanan Shilpa , Khera Tanvi , Kelly Lauren , Mathur Pooja A. , Shanker Akshay , Novack Lena , Pérez-Robles Ruth , Hoffman Kim A. , Sadhasivam Senthil Kumar , Subramaniam Balachundhar
Published: July 2022

Background

Yoga practices, including breathing, meditation, and posture protocols (asanas), have been shown to facilitate physical and mental wellbeing.

Methods

Seasoned yoga practitioners were recruited from the Isha Foundation. Recruitment of the comparison group was achieved using snowball sampling and were not yoga practitioners. Participants in the non-yoga group were randomized to a 3-min Isha practice or a comparator group asked to perform 15-min of daily reading. Participants completed a series of web-based surveys (REDCap) at baseline, 6, and 12 weeks. These surveys include validated scales and objective questions on COVID-19 infection and medical history. The validated questionnaires assess for: perceived stress (PSS), mood states [anxiety and depression (PHQ-4), joy (DPES-Joy subscale)], mindfulness attention and awareness (MAAS), resilience (BRS), mental wellbeing (WEMWBS) and recovery from traumatic event (PTGI). Weekly activity diaries were employed as a tool for collecting compliance information from study participants. Perceived stress scale scores were identified as primary outcome for this study.

Findings

The median Perceived Stress Scale (PSS) score for the yoga practitioners compared to the active and placebo comparators was significantly lower at all time-points: baseline: 11 [IQR 7–15] vs. 16 [IQR 12–21] in both the active and placebo comparators (p < 0.0001); 6 weeks: 9 [IQR 6–13] vs. 12 [IQR 8–17] in the active comparator and 14 [IQR 9–18] in the placebo comparator (p < 0.0001); and 12 weeks: 9 [IQR 5–13] vs. 11.5 [IQR 8–16] in the active comparators and 13 [IQR 8–17] in the placebo comparator (p < 0.0001). Among the randomized participants that were compliant for the full 12 weeks, the active comparators had significantly lower median PSS scores than the placebo comparators 12 weeks [10 (IQR 5–14) vs. 13 (IQR 8–17), p = 0.017]. Further, yoga practitioners had significantly lower anxiety at all three-time points (p < 0.0001), lower depression at baseline and 6 weeks (p < 0.0003), and significantly higher wellbeing (p < 0.0001) and joy (p < 0.0001) at all three-time points, compared to the active and placebo comparator groups.

Interpretation

The lower levels of stress, anxiety, depression, and higher level of wellbeing and joy seen in the yoga practitioners compared to the active and placebo comparators illustrate the impact of regular yoga practices on mental health even during the pandemic.

Trial Registration

ClinicalTrials.gov, identifier: NCT 04498442.
Occupational Exposure to Poorly Soluble Low Toxicity Particles and Cardiac Disease: A Look at Carbon Black and Titanium Dioxide
Authors: McCunney Robert J. , Yong Mei , Warheit David B. , Morfeld Peter
Published: July 2022

Environmental particulate exposure and the potential risk to people with various types of cardiac diseases, most notably cardiovascular disease, have aroused scientific and regulatory interest worldwide. Epidemiological studies have shown associations between exposure to airborne environmental particulate matter (PM) and mortality from cardiovascular disease (CVD). The associations reported, however, are complex and may not involve a direct role for PM, since air pollutants are diverse and highly correlated. This study examines the potential role of occupational exposure to two types of particles, namely, manufactured carbon black (CB) and titanium dioxide (TiO2), on the risk of cardiovascular disease. To address the risk of cardiovascular disease from exposure to carbon black and titanium dioxide, as reflective of poorly soluble low toxicity particles, we reviewed the published cohort mortality studies of occupational exposure to carbon black and titanium dioxide. Mortality studies of carbon black have been conducted in the United States, Germany, and the United Kingdom. Five mortality studies related to workers involved in the manufacture of titanium dioxide in the United States and Europe have also been conducted. In addition, a meta-analysis of the three-carbon black mortality studies was performed. In the random-effects meta-analysis, full cohort meta-SMRs were 1.01 (95% confidence interval (CI): 0.79–1.29) for heart disease; 1.02 (95% CI: 0.80–1.30) for ischemic heart disease; and 1.08 (95% CI: 0.74–1.59) for acute myocardial infarction (AMI) mortality. A small but imprecise increased AMI mortality risk was suggested for cumulative exposure by a meta-HR = 1.10 per 100 mg/m3-years (95% CI: 0.92–1.31) but not for lugged exposures, that is, for recent exposures. Results of five cohort mortality studies of titanium dioxide workers in the United States and Europe showed no excess in all heart disease or cardiovascular disease. In the most recent study in the United States, an internal analysis, that is, within the cohort itself, with no lag time, showed that the exposure group 15–35 mg/m3-years yielded a significantly increased risk for heart disease; however, there was no evidence of increasing risk with increasing exposure for any of the exposure categories. In contrast to environmental studies, the results of cohort mortality studies do not demonstrate that airborne occupational exposure to carbon black and titanium dioxide particulates increases cardiovascular disease mortality. The lack of a relationship between carbon black and titanium dioxide and CVD mortality suggests that the associations reported in air pollution studies may not be driven by the particulate component.
Antiviral treatment in outpatients with herps zoster in six major areas of China, 2010–2019
Authors: Yu Zhenwei , Zhao Yuhua , Jin Jiayi , Zhu Jianping , Yu Lingyan , Han Gang
Published: July 2022

Objective

The objective of this study was to assess the status and trends of antiviral treatment in outpatients with herpes zoster in China.

Methods

Prescription data on antiviral drugs were extracted from the database of the Hospital Prescription Analysis Program of China according to the inclusion criteria. Yearly prescriptions and costs were calculated, and trends were analyzed. The trends were further stratified by age, sex, and specific drug use. The distribution of defined daily costs (DDCs) of valaciclovir and famciclovir were analyzed, and trends in the median DDCs were identified.

Results

A total of 132,911 prescriptions from 49 hospitals located in six major areas of China were included in the analysis. The yearly prescriptions containing antivirals increased from 8,819 in 2010 to 16,361 in 2019. The percentage of prescriptions for patients aged 65 years and above also increased (27.7% in 2010 to 31.0% in 2019), and the number of prescriptions for females was higher than those for males (P < 0.001). The average cost of antivirals per prescription decreased; thus, the yearly cost showed no increasing trend. The main prescribed antivirals were valaciclovir and famciclovir, which progressively increased in prescriptions. The use of acyclovir decreased during the study period. Prescriptions containing topical formulations, acyclovir and penciclovir, both increased. The DDCs of valaciclovir and famciclovir decreased dramatically.

Conclusion

The use of antivirals has increased over the decade, while the cost has not. Antiviral treatments adhere well to recent recommendations, except for the use of topical antivirals. The findings of this study may benefit the healthcare source allocation and management of herpes zoster in China.
Can genetics guide exercise prescriptions in osteoarthritis?
Authors: Espin-Garcia Osvaldo , Baghel Madhu , Brar Navraj , Whittaker Jackie L. , Ali Shabana Amanda
Published: July 2022

Osteoarthritis (OA) is the most common form of arthritis and has a multifactorial etiology. Current management for OA focuses on minimizing pain and functional loss, typically involving pharmacological, physical, psychosocial, and mind-body interventions. However, there remain challenges in determining which patients will benefit most from which interventions. Although exercise-based interventions are recommended as first-line treatments and are known to be beneficial for managing both the disease and illness of OA, the optimal exercise “prescription” is unknown, due in part to our limited understanding of the precise mechanisms underlying its action. Here we present our perspective on the potential role of genetics in guiding exercise prescription for persons with OA. We describe key publications in the areas of exercise and OA, genetics and OA, and exercise and genetics, and point to a paucity of knowledge at the intersection of exercise, genetics, and OA. We suggest there is emerging evidence to support the use of genetics and epigenetics to explain the beneficial effects of exercise for OA. We identify missing links in the existing research relating to exercise, genetics, and OA, and highlight epigenetics as a promising mechanism through which environmental exposures such as exercise may impact OA outcomes. We anticipate future studies will improve our understanding of how genetic and epigenetic factors mediate exercise-based interventions to support implementation and ultimately improve OA patient care.
The Use of Androgen Deprivation Therapy in Combination With Radiation for Localized Prostate Cancer
Authors: Anderson Eric M. , McBride Sean M.
Published: July 2022

Context

The combined use of androgen deprivation therapy (ADT) and radiotherapy in the initial treatment of intermediate- and high-risk prostate cancer is well established.

Objectives

This study aims to review level 1 evidence and post-hoc analyses from prospective studies to determine the benefit of the addition of ADT to curative radiotherapy in prostate cancer and provide suggestions for future combinatorial trials in localized disease.

Evidence Acquisition

We used PubMed with the terms “radiation”, “ADT”, and “prostate” to identify randomized controlled trials that compared curative therapy alone to curative therapy with androgen deprivation therapy conducted from 1980 to the present extracted by the senior author. For critical questions for which randomized data were unavailable, we used studies selected by the senior author that relied on post-hoc analyses from prospective randomized trials in an attempt to provide substantive answers.

Evidence Synthesis

There is strong and unequivocal evidence that variable-length ADT in combination with curative dose radiotherapy improves biochemical recurrence-free survival, cause-specific survival (CSS), and overall survival in intermediate- and high-risk prostate cancer.

Evidence Summary

ADT should be a component of treatment for most men with unfavorable intermediate- and high-risk prostate cancer receiving curative dose radiotherapy
Repeated practice runs during on-snow training do not generate any measurable neuromuscular alterations in elite alpine skiers
Authors: Alhammoud Marine , Girard Olivier , Hansen Clint , Racinais Sébastien , Meyer Frédéric , Hautier Christophe André , Morel Baptiste
Published: July 2022

Background

Alpine skiers typically train using repeated practice runs requiring high bursts of muscle activity but there is little field-based evidence characterizing neuromuscular function across successive runs.

Purpose

To examine the impact of repeated ski runs on electromyographic activity (EMG) of the knee extensors and flexors in elite alpine skiers.

Methods

Nineteen national team alpine skiers were tested during regular ski training [Slalom (SL), Giant Slalom (GS), Super Giant Slalom and Downhill (Speed)] for a total of 39 training sessions. The surface EMG of thevastus lateralis(VL),rectus femoris(RF),vastus medialis(VM),biceps femoris(BF) andsemimembranosus/semitendinosus(SMST) muscles was continuously recorded along with right knee and hip angles. The EMGroot mean squaresignal was normalized to a maximal voluntary contraction (%MVC). The first and fourth runs of the training session were compared.

Results

There was no meaningful main effect of run on EMG relative activation time or mean power frequency beyond the skier's intrinsic variability. However, EMG activity of thevastiiincreased from the first to the fourth run in SL [VM, ~+3%MVC for IL and outside leg (OL),p= 0.035)], speed (VL, IL:+6%/OL:+11%,p= 0.015), and GS (VM, IL:0/OL:+7%,p< 0.001); the later with an interaction with leg (p< 0.001) due to a localized increase on the OL. The run time and turn time did not change from the first to the fourth run. There were no meaningful changes in angular velocities, amplitude of movement, or maximal and minimal angles.

Conclusion

Neuromuscular activity remains highly stable in elite skiers with low variability across four runs.
What works to reduce sedentary behavior in the office, and could these intervention components transfer to the home working environment?: A rapid review and transferability appraisal
Authors: Morton Sarah , Fitzsimons Claire , Jepson Ruth , Saunders David H. , Sivaramakrishnan Divya , Niven Ailsa
Published: July 2022

Background

Working patterns have changed dramatically due to COVID-19, with many workers now spending at least a portion of their working week at home. The office environment was already associated with high levels of sedentary behavior, and there is emerging evidence that working at home further elevates these levels. The aim of this rapid review (PROSPERO CRD42021278539) was to build on existing evidence to identify what works to reduce sedentary behavior in an office environment, and consider whether these could be transferable to support those working at home.

Methods

The results of a systematic search of databases CENTRAL, MEDLINE, Embase, PsycInfo, CINHAL, and SportDiscus from 10 August 2017 to 6 September 2021 were added to the references included in a 2018 Cochrane review of office based sedentary interventions. These references were screened and controlled peer-reviewed English language studies demonstrating a beneficial direction of effect for office-based interventions on sedentary behavior outcomes in healthy adults were included. For each study, two of five authors screened the title and abstract, the full-texts, undertook data extraction, and assessed risk of bias on the included studies. Informed by the Behavior Change Wheel, the most commonly used intervention functions and behavior change techniques were identified from the extracted data. Finally, a sample of common intervention strategies were evaluated by the researchers and stakeholders for potential transferability to the working at home environment.

Results

Twenty-two studies including 29 interventions showing a beneficial direction of effect on sedentary outcomes were included. The most commonly used intervention functions were training (n = 21), environmental restructuring (n = 21), education (n = 15), and enablement (n = 15). Within these the commonly used behavior change techniques were instructions on how to perform the behavior (n = 21), adding objects to the environment (n = 20), and restructuring the physical environment (n = 19). Those strategies with the most promise for transferring to the home environment included education materials, use of role models, incentives, and prompts.

Conclusions

This review has characterized interventions that show a beneficial direction of effect to reduce office sedentary behavior, and identified promising strategies to support workers in the home environment as the world adapts to a new working landscape.

Systematic Review Registration:https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021278539, identifier CRD42021278539.
Case report: Use of penicillin G potassium in poloxamer 407 gel to aid in healing of an equine sublingual abscess
Authors: Larsen Elizabeth A. , Lack Amy C. , Wassack Erica
Published: July 2022

The use of poloxamer 407 gels have been reported in several studies to prolong the release of drugs at the injection site. Oral lesions unrelated to dental disease are rare but may result in ulceration and sequestration of bone. To date, there have been no reports on the use of penicillin G potassium poloxamer 407 gel and its effect on wound healing. The present case report describes the use of a penicillin G potassium poloxamer 407 gel for the treatment of a sublingual abscess involving the mandible in a 20 year old Arabian mare who initially presented with acute onset of dysphagia, hypersalivation, and a mass under the tongue. A presumptive diagnosis of lingual cellulitis was made, and a sublingual abscess ruptured on day 7 of hospitalization. In this case, poloxamer 407 gel was used to decrease wound contamination, protect the exposed mandible, and potentially prolong the release of penicillin G potassium into the wound.
Case Report: Endoscope-Assisted Bilateral Nasal Leech Retrieval in a Dog
Authors: Singh Manpreet , Kumar Amit , Kumar Adarsh , Tyagi Som P. , Wadhawan Rishu
Published: July 2022

A non-descript male dog was presented with symptoms, such as chronic recurrent epistaxis, sneezing, and episodes of nasal leech infestation from the past 3 months. The dog was subjected to basic clinical examination, hemato-biochemistry test, and radiographic examination before rhinoscopy. Rhinoscopy was performed with Karl Storz's 5-mm video-otoscope under general anesthesia. Leech infestation in the nasal cavity was found to be the cause of the epistaxis under rhinoscopic examination. The endoscopic guided retrieval of the leech from both the nostrils was successfully done with help of grasping forceps without any major complication. The video-otoscope-guided retrieval of nasal leeches was quite convenient and also provide the exact localization of the nasal leech.
Dark Type Dynamical Systems: The Integrability Algorithm and Applications
Authors: Prykarpatsky Yarema A. , Urbaniak Ilona , Kycia Radosław A. , Prykarpatski Anatolij K.
Published: July 2022

Based on a devised gradient-holonomic integrability testing algorithm, we analyze a class of dark type nonlinear dynamical systems on spatially one-dimensional functional manifolds possessing hidden symmetry properties and allowing their linearization on the associated cotangent spaces. We described main spectral properties of nonlinear Lax type integrable dynamical systems on periodic functional manifolds particular within the classical Floquet theory, as well as we presented the determining functional relationships between the conserved quantities and related geometric Poisson and recursion structures on functional manifolds. For evolution flows on functional manifolds, parametrically depending on additional functional variables, naturally related with the classical Bellman-Pontriagin optimal control problem theory, we studied a wide class of nonlinear dynamical systems of dark type on spatially one-dimensional functional manifolds, which are both of diffusion and dispersion classes and can have interesting applications in modern physics, optics, mechanics, hydrodynamics and biology sciences. We prove that all of these dynamical systems possess rich hidden symmetry properties, are Lax type linearizable and possess finite or infinite hierarchies of suitably ordered conserved quantities.
Hepatocellular Carcinoma in a Free-Ranging Three-Toed Sloth (Bradypus variegatus)
Authors: de Souza Alex Junior Souza , Malheiros Andreza Pinheiro , da Silva Victor Lopes , da Silva Tereza Cristina , Cogliati Bruno , de Sá Lilian Rose Marques
Published: July 2022

The increasing interest of tumors in wildlife is important for biodiversity conservation and for monitoring environmental agents and/or contaminants with potential impact on human health. Here we described the occurrence of hepatocellular carcinoma (HCC) in noncirrhotic liver of a free-ranging three-toed sloth (Bradypus variegatus) from the Atlantic Forest biome in Brazil. The HCC showed a moderate mononuclear inflammatory infiltrate within the tumor tissue but with no inflammation and fibrosis in the adjacent liver tissue. Upon immunohistochemistry, neoplastic cells were diffusely positive for HepPar-1 and glutamine-synthetase presenting an irregular and random immunostaining pattern; β-catenin was positive in the cytoplasmic membrane of malignant hepatocytes; and cytokeratin 19 immunostaining was restricted to bile duct epithelial cells. The liver tissue was negative for HBV-like and HCV-like viruses assessed by molecular tests. The potential similarity of pathogenesis may reinforce the need for research on environmental and/or infectious agents associated with HCC that may contribute to the understanding of cancer in wildlife.
The ClassyFarm System in Tuscan Beef Cattle Farms and the Association between Animal Welfare Level and Productive Performance
Authors: Mariottini Francesco , Giuliotti Lorella , Gracci Marta , Benvenuti Maria Novella , Salari Federica , Arzilli Luca , Martini Mina , Roncoroni Cristina , Brajon Giovanni
Published: July 2022

In 2018, the Italian Ministry of Health introduced the ClassyFarm system in order to categorize the level of risk related to animal welfare. The ClassyFarm checklist for beef cattle is divided into four areas: Areas A “Farm management and personnel”; B “Structures and equipment”; C “Animal-based measures”; and “Emergency plan and alert system”. Answers contribute to the final Animal Welfare Score (AWS) and to the score of each area. The aim of this work was to assess the animal welfare level on 10 Tuscan beef cattle farms through the ClassyFarm checklist and to examine the relationship between the level of animal welfare on final weight (FW), carcass weight (CW), weight gain (WG), and average daily gain (ADG). The AWS was divided into four classes, and the scores for each area were divided into three classes. The analysis of variance was applied, and AWS class, sex, and breeding techniques (open and closed cycle) were included in the model. The AWS class and sex had a highly significant influence on all parameters, while the breeding technique did not significantly influence any parameter. Farms classified as excellent presented a higher FW (677.9 kg) than those classified as good and insufficient, and the same trend was found for the ADG. The classes obtained in Areas A and C had a highly significant influence on all the parameters investigated. The classes obtained in Area B significantly influenced FW and WG. In conclusion, the productive response of the animals seemed to benefit from the welfare conditions.
Application of a Bio-Economic Model to Demonstrate the Importance of Health Traits in Herd Management of Lithuanian Dairy Breeds
Authors: Marašinskienė Šarūnė , Šveistienė Rūta , Kosińska-Selbi Barbara , Schmidtmann Christin , Ettema Jehan Frans , Juškienė Violeta , Kargo Morten
Published: July 2022

Assessing the economic importance of traits is crucial for delivering appropriate breeding goals in dairy cattle breeding. The aim of the present study was to calculate economic values (EV) and assign the importance of health traits for three dairy cattle breeds: Lithuanian Black-and-White open population (LBW), Lithuanian Red open population (LR) and Lithuanian Red old genotype (LROG). The EV estimation was carried out using a stochastic bio-economic model SimHerd, which allows the simulation of the expected monetary gain of dairy herds. The simulation model was calibrated for LBW, LR and LROG breeds, taking into account breed-specific phenotypic and economic data. For each trait, two scenarios were simulated with a respective trait at different phenotypic levels. To obtain the EVs, the scenarios were compared with each other in terms of their economic outcomes. In order to avoid the double counting of the effects, the output results were corrected using a multiple regression analysis with mediator variables. The EVs were derived for the traits related to production ECM (energy-corrected milk), fertility, calving traits, calf survival, cow survival and direct health. To demonstrate the importance of health traits in herd management, we provided reliable EVs estimates for functional traits related to herd health. The highest EV for direct health traits, caused by an increase in of 1 percentage point, were those found for mastitis (EUR 1.73 to EUR 1.82 per cow-year) and lameness (EUR 1.07 to EUR 1.27 per cow-year). The total costs per case of ketosis, milk fever and metritis ranged from EUR 1.01 to EUR 1.30, EUR 1.14 to EUR 1.26 and EUR 0.95 to EUR 1.0, respectively. The highest economic values of dystocia were estimated for LROG (EUR −1.32), slightly lower for LBW (EUR −1.31) and LR (EUR −1.23). The results of this study show the importance of health traits to the economic features of cattle herd selection of new breeding goal and this would improve the herd health. The economic evaluation of the functional traits analyzed in this study indicated the significant economic importance of the functional traits in Lithuanian dairy cattle breeds.
Functional Connectivity within the Frontal–Striatal Network Differentiates Checkers from Washers of Obsessive-Compulsive Disorder
Authors: Yu Jianping , Xie Minyao , Song Shasha , Zhou Ping , Yuan Fangzheng , Ouyang Mengyuan , Wang Chun , Liu Na , Zhang Ning
Published: July 2022

Background: Obsessive-compulsive disorder (OCD) is a psychiatric disorder with high clinical heterogeneity manifested by the presence of obsessions and/or compulsions. The classification of the symptom dimensional subtypes is helpful for further exploration of the pathophysiological mechanisms underlying the clinical heterogeneity of OCD. Washing and checking symptoms are the two major symptom subtypes in OCD, but the neural mechanisms of the different types of symptoms are not yet clearly understood. The purpose of this study was to compare regional and network functional alterations between washing and checking OCD based on resting-state functional magnetic resonance imaging (rs-fMRI). Methods: In total, 90 subjects were included, including 15 patients in the washing group, 30 patients in the checking group, and 45 healthy controls (HCs). Regional homogeneity (ReHo) was used to compare the differences in regional spontaneous neural activity among the three groups, and local indicators were analyzed by receiver operating characteristic (ROC) curves as imaging markers for the prediction of the clinical subtypes of OCD. Furthermore, differently activated local brain areas, as regions of interest (ROIs), were used to explore differences in altered brain functioning between washing and checking OCD symptoms based on a functional connectivity (FC) analysis. Results: Extensive abnormalities in spontaneous brain activity involving frontal, temporal, and occipital regions were observed in the patients compared to the HCs. The differences in local brain functioning between checking and washing OCD were mainly concentrated in the bilateral middle frontal gyrus, right supramarginal gyrus, right angular gyrus, and right inferior occipital gyrus. The ROC curve analysis revealed that the hyperactivation right middle frontal gyrus had a better discriminatory value for checking and washing OCD. Furthermore, the seed-based FC analysis revealed higher FC between the left medial superior frontal gyrus and right caudate nucleus compared to that in the healthy controls. Conclusions: These findings suggest that extensive local differences exist in intrinsic spontaneous activity among the checking group, washing group, and HCs. The neural basis of checking OCD may be related to dysfunction in the frontal–striatal network, which distinguishes OCD from washing OCD.
Gastrointestinal Stromal Tumors (GIST): A Population-Based Study Using the SEER Database, including Management and Recent Advances in Targeted Therapy
Authors: Khan Jaffar , Ullah Asad , Waheed Abdul , Karki Nabin Raj , Adhikari Nawaraj , Vemavarapu Lakshmi , Belakhlef Sami , Bendjemil Samy Malik , Mehdizadeh Seraj Siamak , Sidhwa Feroze , Ghleilib Intisar , Foroutan Shahin , Blakely Andrew M. , Del Rivero Jaydira , Karim Nagla Abdel , Vail Eric , Heneidi Saleh , Mesa Hector
Published: July 2022

Introduction: Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasm of the gastrointestinal (GI) system. Most GISTs originate from the interstitial cells of Cajal (ICC), the pacemaker cell situated between the circular and longitudinal layers of the muscularis propria along the GI tract. In this population-based study using the SEER database, we sought to identify demographic, clinical, and pathologic factors that affect the prognosis and survival of patients with this neoplasm. Molecular genetic advances, current management guidelines, and advances in targeted therapy are discussed. Methods: Demographic and clinical data from GIST patients were retrieved from the SEER research plus database for the period 2000–2018. Statistical analysis was performed with IBM SPSS® v20.2 software using the Chi-square test, paired t-test, multivariate analysis, and Kaplan–Meier functions. Results: A total of 10,833 patients with GIST were identified. Most patients were between 60–74 years of age: 40%, Caucasian: 68%, and the male to female ratio was 1.1:1. The most common primary tumor sites were stomach: 63%, small intestine: 30%, rectum: 3%, and esophagus: 0.7%. When reported, the grade of differentiation was well: 38%, moderately: 32%, undifferentiated: 19%, poorly: 12%. The size of most tumors ranged between 6–10 cm: 36% and they were treated by surgical intervention: 82% and/or chemotherapy/targeted therapy: 39%. The stage was localized: 66%, advanced: 19%, and regional: 15%. The 5-year survival was 74% (95% confidence interval (95% CI) = 72.6–74.7), and the 5-year cause-specific survival 82% (95% CI = 80.7–82.6). The 5-year cause-specific survival by treatment included surgery at 86% (95% CI = 85.4–87.3), chemotherapy/targeted therapy with or without surgery at 77% (95% CI = 75.7–78.9), and radiation at 75% (95% CI = 74.5–80). On multivariable analysis tumor size > 5 cm, poorly and undifferentiated grade, age > 60, and distant metastases at presentation were associated with worse overall survival. Conclusion: GISTs comprise 1–2% of malignancies of the GI tract, usually affect male Caucasians between the ages of 60 and 74 years, most tumors occur in the stomach and small intestine, and are usually >5 cm, but still localized, at the time of diagnosis. Most tumors receive multimodality surgical and chemotherapy/targeted therapy treatment, with a 5-year overall survival of 74% and cause-specific survival of 82%. GIST patients would benefit from enrollment in large clinical trials to establish better therapy guidelines for unresectable, treatment-refractory, and recurrent tumors.
Establishing a High-Throughput Locomotion Tracking Method for Multiple Biological Assessments in Tetrahymena
Authors: Suryanto Michael Edbert , Vasquez Ross D. , Roldan Marri Jmelou M. , Chen Kelvin H. -C. , Huang Jong-Chin , Hsiao Chung-Der , Tsao Che-Chia
Published: July 2022

Protozoa are eukaryotic, unicellular microorganisms that have an important ecological role, are easy to handle, and grow rapidly, which makes them suitable for ecotoxicity assessment. Previous methods for locomotion tracking in protozoa are largely based on software with the drawback of high cost and/or low operation throughput. This study aimed to develop an automated pipeline to measure the locomotion activity of the ciliated protozoan Tetrahymena thermophila using a machine learning-based software, TRex, to conduct tracking. Behavioral endpoints, including the total distance, velocity, burst movement, angular velocity, meandering, and rotation movement, were derived from the coordinates of individual cells. To validate the utility, we measured the locomotor activity in either the knockout mutant of the dynein subunit DYH7 or under starvation. Significant reduction of locomotion and alteration of behavior was detected in either the dynein mutant or in the starvation condition. We also analyzed how Tetrahymena locomotion was affected by the exposure to copper sulfate and showed that our method indeed can be used to conduct a toxicity assessment in a high-throughput manner. Finally, we performed a principal component analysis and hierarchy clustering to demonstrate that our analysis could potentially differentiate altered behaviors affected by different factors. Taken together, this study offers a robust methodology for Tetrahymena locomotion tracking in a high-throughput manner for the first time.
Pandemic-Related Tenure Timeline Extensions in Higher Education in the United States: Prevalence and Associated Characteristics
Authors: Krukowski Rebecca A. , Blackman Carr Loneke T. , Arigo Danielle
Published: July 2022

Many universities implemented pandemic-related tenure timeline extensions in response to productivity disruptions. However, little is known about the availability, nature, or uptake of these extensions, including which faculty were most likely to extend their timeline. Tenure-track faculty in the United States (n = 385, 64.4% women, 35.3% identifying with a National Institutes of Health-designated racial/ethnic minority group, 73.0% with children, 33.8% with non-child caregiving) completed a survey about their personal/career/institution characteristics, their institution’s pandemic extension policy (if any), and whether they extended their timeline. Overall, 94.0% reported that their institutions provided either an extension, unless faculty opted out, or an extension that could be requested. Most respondents (60.0%) elected to extend their tenure timeline due to the pandemic. Significantly greater proportions of respondents taking an extension were men (77.2%), identified with a NIH-designated racial/ethnic minority group (75.7%), reported non-child caregiving (86.3%), and had previously taken at least one timeline extension (82.4%). Pandemic-related extensions in tenure and promotion dossiers will be common, though they may not fully account for more than a year of disruption and may exacerbate disparities. Consequently, effective preparation for evaluating dossiers and other mitigation strategies are needed, to prevent the loss of faculty members who offer great value to their institutions.
Fabrication of Novel Bio-Composites Based on Rice Milk for the Delivery of Capsaicinoids as Green Herbicides against Cynodon dactylon Weed
Authors: Viscusi Gianluca , Lamberti Elena , Aquino Giovanna , Rodriquez Manuela , Gorrasi Giuliana
Published: July 2022

In this paper, rice milk-based beads were fabricated through gelation in a calcium chloride solution. Green extraction of chili pepper in water/ethanol was conducted in order to obtain powder extract (PE) rich in apigenin C-pentosyl-C-hexoside, capsaicin, and dihydrocapsaicin. The effect of capsaicinoids loading on beads’ properties was evaluated in terms of morphological and physical properties. Swelling phenomena and diameter variation of beads were studied as a function of time proving correspondence with the PE amount. The effect of ionic strength on bead swelling was considered. Kinetic studies of PE release were conducted to investigate the release profiles, which were modeled through a modified Baker and Lonsdale model by considering the change in mean diameter over time. The effect of PE loading was then correlated to the growth of Cynodon dactylon weed through in vivo tests. The results corroborate the performances of the encapsulated PE to be used as natural and green herbicide release systems able to inhibit the growth and the proliferation of weeds.
Molecular Structures of the Silicon Pyridine-2-(thi)olates Me3Si(pyX), Me2Si(pyX)2 and Ph2Si(pyX)2 (py = 2-Pyridyl, X = O, S), and Their Intra- and Intermolecular Ligand Exchange in Solution
Authors: Seidel Anne , Weigel Mareike , Ehrlich Lisa , Gericke Robert , Brendler Erica , Wagler Jörg
Published: July 2022

A series of pyridine-2-olates (pyO) and pyridine-2-thiolates (pyS) of silicon was studied in solid state and in solution. The crystal structures of Me3Si(pyO) (1a), Me3Si(pyS) (1b), Me2Si(pyO)2 (2a), Me2Si(pyS)2 (2b), Ph2Si(pyO)2 (3a) and Ph2Si(pyS)2 (3b) were determined by X-ray diffraction. For that purpose, crystals of the (at room temperature) liquid compounds 1a and 1b were grown in a capillary on the diffractometer. Compounds 1a, 1b, 2a, 2b and 3a feature tetracoordinate silicon atoms in the solid state, whereas 3b gave rise to a series of four crystal structures in which the Si atoms of this compound are hexacoordinate. Two isomers (3b1 with all-cis arrangement of the C2N2S2 donor atoms in P1¯, and 3b2 with trans S-Si-S axis in P21/n) formed individual crystal batches, which allowed for their individual 29Si NMR spectroscopic study in the solid state (the determination of their chemical shift anisotropy tensors). Furthermore, the structures of a less stable modification of 3b2 (in C2/c) as well as a toluene solvate 3b2 (toluene) (in P1¯) were determined. In CDCl3, the equimolar solutions of the corresponding pairs of pyO and pyS compounds (2a/2b and 3a/3b) showed substituent scrambling with the formation of the products Me2Si(pyO)(pyS) (2c) and Ph2Si(pyO)(pyS) (3c), respectively, as minor components in the respective substituent exchange equilibrium.
Response of Soil Fauna Diversity to Agricultural Landscape Het-Erogeneity in the Middle and Lower Reaches of the Yellow River—A Case Study in Gongyi City, China
Authors: Zhang Panpan , Zhang Chenchen , Ding Shunping , Bian Ziqi , Li Peikun , Zhang Jian , Ding Shengyan
Published: July 2022

Soil fauna contribute to important ecological functions such as improving soil structure and promoting nutrient circulation. They are the common environmental indicators in agricultural landscape. Therefore, this study took Gongyi City, Henan Province, China, located in the middle and lower reaches of the Yellow River, as the study area, to explore the impact of multi-scale landscape heterogeneity on soil fauna diversity and the response of soil fauna to it. Our results showed that patch types and degree of fragmentation in the study area increased significantly with the increase of spatial scale. The diversity indices of soil fauna in different habitats showed that the Shannon-Wiener diversity index, Simpson’s diversity index, Pielou’s evenness index, and Margalef richness index were the lowest in farmland habitat. Diversity indices of artificial forests were higher than those of natural forests. Diversity indices of soil fauna under different geomorphic conditions showed that Pielou’s evenness index and Margalef richness index had significant differences under different geomorphic conditions (p < 0.05). The effects of multi-scale landscape heterogeneity on soil fauna diversity were different. In the 150 m buffer zone, soil fauna community composition and diversity indices were strongly correlated with patch richness index, patch richness density, and other landscape indices (p < 0.05). Meanwhile, the contribution rate of landscape index to soil fauna community composition were 45.05%, 32.5%, and 42% in farmland, plantation, and natural forest, respectively. Therefore, the 150 m buffer zone could be used as the characteristic response scale of soil fauna diversity. The multi-scale interaction of landform, habitat, and landscape also had a significant impact on soil fauna diversity.
The Spatial Heterogeneity Effect of Green Finance Development on Carbon Emissions
Authors: Feng Langang , Shang Shu , An Sufang , Yang Wenli
Published: July 2022

This paper uses the entropy method to estimate China’s green financial development from four aspects, namely, green credit, green securities, green insurance, and green investment, based on the provincial-level panel data from 2008 to 2019. The spatial Durbin model (SDM) is adopted to estimate the spatial effect of green finance on carbon emissions. We then compare the heterogeneous effect in the South and North of China. The results show that China’s green financial development can significantly reduce carbon emissions, and regional heterogeneities are obvious. In the South of China, this effect from local and adjacent regions is not significant, while on the whole, green finance can significantly reduce carbon emissions; but for Northern China, this effect is not significant; nationally, the development of green finance and carbon emissions in adjacent areas showed an inverted U-shaped relationship. China’s green financial development and carbon emissions also showed an inverted U-shaped relationship. These results suggest that the effect of green finance development on carbon emissions exhibits substantial regional heterogeneity in China. Our paper provides some concrete empirical evidence for policymakers to formulate green financial policies to achieve the double carbon goal in China.
Research Progress in Metal-Organic Framework Based Nanomaterials Applied in Battery Cathodes
Authors: Mechili Maria , Vaitsis Christos , Argirusis Nikolaos , Pandis Pavlos K. , Sourkouni Georgia , Zorpas Antonis A. , Argirusis Christos
Published: July 2022

Metal-Organic Frameworks have attracted profound attention the latest years for use in environmental applications. They can offer a broad variety of functions due to their tunable porosity, high surface area and metal activity centers. Not more than ten years ago, they have been applied experimentally for the first time in energy storage devices, such as batteries. Specifically, MOFs have been investigated thoroughly as potential materials hosting the oxidizing agent in the cathode electrode of several battery systems such as Lithium Batteries, Metal-Ion Batteries and Metal-Air Batteries. The aim of this review is to provide researchers with a summary of the electrochemical properties and performance of MOFs recently implemented in battery cathodes in order to provide fertile ground for further exploration of performance-oriented materials. In the following sections, the basic working principles of each battery system are briefly defined, and special emphasis is dedicated to MOF-based or MOF-derived nanomaterials, especially nanocomposites, which have been tested as potential battery cathodes.
PV/Battery Grid Integration Using a Modular Multilevel Isolated SEPIC-Based Converter
Authors: Nasr Esfahani Fatemeh , Darwish Ahmed , Massoud Ahmed
Published: July 2022

Photovoltaic (PV) plants can be built rapidly when compared with other conventional electrical plants; hence, they are a competent candidate for supplying the electricity grid. The output power of the PV modules can be used in plug-in electric vehicles (PEVs) DC charging stations to reduce the burden on the electricity grid, particularly during peak load hours. To integrate PV modules and electric vehicles (EVs) with the electricity grid, the modular multilevel converters (MMCs) topologies producing staircase voltage waveforms are preferred as they are able to deliver less total harmonic distortion (THD) and higher efficiency in addition to lower voltage stress on semiconductor switches. In conventional centralized MMC topologies, a direct connection to a high-DC-link input voltage is required which is not appropriate for PV plants. A new MMC topology for PV/EV/grid integration is proposed in this paper, where the individual PV arrays are directly connected to each phase of the AC grid to harvest the maximum available power point. A current-source converter (CSC) based on a single-stage isolated SEPIC converter is adopted as the submodule (SM) for the proposed MMC topology given its outstanding features, such as low input ripple current, high efficiency, high power factor, and flexible output voltage higher or lower than the input voltage. The single-stage SMs can operate in both DC/DC and DC/AC operating modes. Proper controllers for each mode of operation are designed and applied to supply constant current from either the PV modules or the battery cells by eliminating the second-order harmonic component. The performance of the proposed converter is verified by simulations and a downscaled prototype controlled by TMSF28335 DSP.
Digital Twin for the Prediction of Extreme Loads on a Wave Energy Conversion System
Authors: Katsidoniotaki Eirini , Psarommatis Foivos , Göteman Malin
Published: July 2022

Wave energy is a renewable energy source with the potential to contribute to the global electricity demand, but a remaining challenge is the survivability of the wave energy converters in harsh offshore conditions. To understand the system dynamics and improve the reliability, experimental and numerical studies are usually conducted. However, these processes are costly and time-consuming. A statistical model able to provide equivalent results is a promising approach. In this study, the digital twin of the CFD solution is developed and implemented for the prediction of the force in the mooring system of a point-absorber wave energy converter during extreme wave conditions. The results show that the digital twin can predict the mooring force with 90.36% average accuracy. Moreover, the digital twin needs only a few seconds to provide the solution, while the CFD code requires up to several days. By creating a digital analog of a wave energy converter and showing that it is able to predict the load in critical components during extreme wave conditions, this work constitutes an innovative approach in the wave energy field.
Study on Heating and Cooling Performance of Air-to-Water Heat Pump System for Protected Horticulture
Authors: Rasheed Adnan , Lee Jong Won , Kim Hyeon Tae , Lee Hyun Woo
Published: July 2022

There is much interest in alternative energy sources for greenhouse heating and cooling, due to the impact of severe climatic conditions and increasing fossil fuel prices. The main objective of this study was to experimentally evaluate the performance of an air-to-water heat pump (AWHP) system to fulfil the cooling and heating energy requirements of a three-spanned greenhouse under local weather conditions in Daegu, South Korea. For this purpose, a system comprising three air-to-water heat pumps, a water storage tank, and fan coil units (FCU)s was designed. Experiments were conducted extensively during the summer and winter seasons. The maximum heating and cooling energy supply to the greenhouse was 210 kcal∙h−1∙m−2 and 230 kcal∙h−1∙m−2, respectively. Based on the outcomes of this study, the AWHP system can provide heating during the winter season. During the summer season, the FCU capacity was insufficient to provide the desired cooling to achieve the setpoint air temperature inside the studied greenhouse. To achieve the desired microclimate during the summer season, the capacity of the FCU or number of FCUs must be increased. Moreover, one AWHP with a water storage tank, was sufficient to provide the required cooling and heating in both seasons. Two additional AWHPs can be used to provide energy to more greenhouse areas in the future. The results can be used as a case study to find a more resilient and reliable source for greenhouse heating and cooling. The average COP of the AWHP in heating mode was 2.2, while on cooling mode, it was 3.2.