bluuebunny/crossref_metadata_2025 huggingface dataset:
Novel Benzothiazole Boc-Phe-Phe-Bz Derivative Dipeptide Forming Fluorescent and Nonlinear Optical Self-Assembled Structures
Authors: Baptista Rosa M. F. , Santos Daniela , Cunha Nelssom Fernandez , Castro M. Cidália R. , Rodrigues Pedro V. , Machado Ana V. , Belsley Michael S. , Gomes Etelvina de Matos
Published: January 2025

This work explores the self-assembly and optical properties of a novel chiral, aromatic-rich Boc-Phe-Phe dipeptide derivative functionalized with a benzothiazole bicyclic ring, which forms supramolecular structures. Leveraging the well-known self-assembling capabilities of diphenylalanine dipeptides, this modified derivative introduces a heterocyclic benzothiazole unit that significantly enhances the fluorescence of the resulting nanostructures. The derivative’s rich aromatic character drives the formation of supramolecular structures through self-organization mechanisms influenced by quantum confinement. By adjusting the solvent system, the nanostructures exhibit tunable morphologies, ranging from nanospheres to nanobelts. Furthermore, the nonlinear optical properties of these self-assembled structures are studied and an estimated deff of ~0.9 pm/V is obtained, which is comparable to that reported for the highly aromatic triphenylalanine peptide.
Modern Technologies for Improving Broiler Production and Welfare: A Review
Authors: Brassó Lili D. , Komlósi István , Várszegi Zsófia
Published: January 2025

The increasing level of poultry meat production, the lack of human workforce, and the rapid development of information technology have led to the application of precision livestock farming (PLF) systems in the poultry sector, as in other livestock sectors. PLF tools provide continuous, real-time, accurate, and non-invasive data acquisition regarding environmental and production parameters, animal health and behaviour. PLF technologies include sensors, cameras, and microphones for data collection, as well as networks, software, and computer systems for data processing and analysis. Most precision tools focus on some parameters or a group of parameters which are closely related and only a few provides a more complex view (i.e. multi-purpose robots). Besides the advantages, limitations of the systems should also be considered before the application. Limitations include technical failures and breakdowns, pathogen transmission, problems with the reliability of results, the reduction of human-animal contacts and animal welfare. Combination of the accessible technologies of different purposes should be applied on each farm to provide a complete, reliable technological background for farming. Tools should be connected to enable communication with each other and create a complex, reliable, precise background for farming. This also facilitates management decisions and the treatment of so-called “Big Data”
Thermodynamic Evaluation of the Potential of a Sorption Storage System for Renewables and Waste Heat Integration
Authors: Ametta Matteo , Maggio Gaetano , Vasta Salvatore
Published: January 2025

This work investigates the potential of a sorption-based thermal energy storage (TES) system for enhancing the integration of renewable energy and waste heat recovery in key sectors—industry, transport, and buildings. Sorption-based TES systems, which utilize reversible sorbent-sorbate reactions to store and release thermal energy, offer long-term storage capabilities with minimal losses. A thermodynamic model, supported by experimental data, evaluates the efficiency of various working pairs under different operating conditions. Key findings demonstrate that water-based solutions (e.g., zeolite and silica gel composites) perform well for residential and transport applications, while methanol-based solutions, such as LiCl-silica/methanol, maintain higher efficiency in industrial contexts. Short-term storage shows higher energy efficiencies compared to long-term applications, and the choice of working pairs significantly influences performance. Industrial applications face unique challenges due to extreme operating conditions, limiting the viable solutions to water-based working pairs. This research highlights the capability of sorption-based TES systems to reduce greenhouse gas emissions, improve energy efficiency, and facilitate a transition to sustainable energy practices. The findings contribute to developing cost-effective and reliable solutions for energy storage and renewable integration in various applications.
Enhancing Early Reading Skills in Young Children Through the Implementation of Alphabet Maze Game
Authors: Samad Munawwarah , Fitriani Dewi , Fariza Siti Rahma , Shidqi Dzulfikar Sauqy
Published: January 2025

Early reading ability is the initial ability of children in the form of the ability to recognize and voice letters. Based on the observations in TKN An-Nada Aceh Selatan, many children's early reading skills still do not recognize letters, have difficulty mentioning letters, are not able to recognize the sound of letters, are not able to mention letters, and are not able to recognize letter symbols. This study aims to determine the application of the letter maze to develop the early reading skills of children in TKN An-Nada Aceh Selatan. This type of research is an experiment with a one-group pretest-posttest design. The population in this study was 45 children, while the sample in this study was 15 children. Data collection techniques were done through observation and documentation. The pretest value obtained is 18.75, and the posttest value is 83.33. The value of tcount is 8.8, and the value of ttable is 1.745. This shows that the value of tcount> ttable is 8.8> 1.761, so there is a rejection of Ho and an acceptance of Ha. So, it can be concluded that there is a difference in the value between the tcount and the ttable, and it can be concluded that the application of the letter maze can develop the ability to read early childhood beginnings at TKN An-Nada Aceh Selatan.
Interactive Storytelling Using Profession Pictures and Storybooks for Children’s Language Acquisition
Authors: Triatna David
Published: January 2025

This study investigates the impact of profession pictures and storybooks on children’s language acquisition. Employing a qualitative descriptive approach, data were collected through direct observation, structured interviews, and documentation. The study involved children aged 5–6 years at Piri Nitikan Kindergarten, Yogyakarta. The storytelling sessions were divided into two groups: one utilizing profession pictures and the other using storybooks. The findings revealed that profession pictures stimulated children’s curiosity and fostered active participation, resulting in notable vocabulary expansion and the use of more complete sentences. Conversely, storybooks enhanced children’s comprehension of narrative structures and encouraged using descriptive language. Both methods promoted meaningful engagement and dynamic learning experiences, offering valuable insights for educators. This study underscores the complementary advantages of profession pictures and storybooks in addressing diverse learner needs, fostering an engaging and effective language acquisition environment.
Perceptions of Parents and Educaators on Risky Play: Balancing Developmental Benefits and Safety in Early Childhood Education
Authors: Jazariyah Jazariyah , Purnamasari Yayu Mega , Pramesti Intan Ayu , Supriani Endang , Khaerunnisa Nabilla Fitria , Vitaloka Dea , Arifah Rike Aulia , Sari Nizma Dwi Kharisma
Published: January 2025

Risky play presents a paradox in early childhood education (ECE): while it offers significant benefits for children’s growth and development, it raises concerns among parents and teachers. This study aims to explore the perceptions of parents and educators regarding risky play in early childhood. A survey approach was employed using a mixed-methods concurrent embedded design, combining quantitative and qualitative descriptive analyses. The study involved 112 participants, comprising early childhood education teachers and parents in Java. Data were collected through questionnaires and interviews to gather insights into parental knowledge about risky play, the types of risky play, their concerns, and their expectations. Quantitative findings revealed that 77% of parents are familiar with risky play, while 30% are not. Parents expressed the highest concern for water-related activities (90.9%), followed by sliding activities (88.4%). Injuries were identified as a significant concern, with 56.6% worried about physical harm and 14.8% about peer influence. Additionally, parents and teachers highlighted the importance of receiving information on risk management in risky play. The findings of this study can inform the development of risk management programs tailored for early childhood education, ensuring a balance between developmental benefits and safety considerations
Leveraging The Animated Video Ibra Berkisah To Prevent Bullying In Early Childhood
Authors: Mashlahah Any Umy , Febriyana Nurul Hidayah , Najiha Nihayatun
Published: January 2025

To prevent bullying in early childhood, it is crucial to introduce children to the impacts of bullying from an early age. As a widely popular platform among children, YouTube can serve as an effective medium for educating them about the consequences of bullying. This research explores how the animated video “Ibra Berkisah,” mainly the episode titled “Bully,” can be used as an educational tool to prevent bullying in early childhood. The study adopts a qualitative descriptive design, which is well-suited for investigating and understanding the animated video “Ibra Berkisah” application in addressing bullying behaviors among young children. Data collection methods likely include observations, interviews, and documentation to evaluate the video’s effectiveness in teaching anti-bullying values. The study involved 26 kindergarten children as participants. The findings indicate that the children could identify bullying behaviors and take proactive steps to prevent such actions in their interactions. The results suggest that the animated video “Ibra Berkisah” is highly suitable for early childhood audiences, as it conveys numerous moral messages in a manner that is easy for children to understand. The video’s engaging format and straightforward narrative make it accessible and appealing, enhancing its effectiveness as an educational tool.
Trends And Opportunities In Fun Science Learning For Early Childhood: A Bibliometric Analysis (2014–2023)
Authors: Noor Faiq Makhdum
Published: January 2025

Research on science learning for early childhood has increased from year to year. Science learning is important during early childhood because it is an important period for laying the foundation for developing children's various potentials and characters. This research aims to analyze research trends in fun science learning for early childhood, visualize existing research trends, and find novelty opportunities for future research based on analysis of research themes that have been carried out so far. This research uses bibliometric techniques using the Scopus database which was conducted on September 27 2024 with the keywords "fun science learning for early childhood". Data files from the Scopus database are downloaded in .csv and .ris formats and visualized using the VOSViewer application. The analysis was carried out over the last ten years starting from 2014 to 2023 with a total of 4.204 documents. Based on the results of the analysis, it was found that the research trend regarding science learning for early childhood has increased from year to year, apart from that there are also four clusters in the VOSViewer visualization, and opportunities for novelty can be seen from several keywords that look small, not dominant, and not has a relationship with other words in the VOSViewer visualization. Novelty opportunities can be found in keywords including children development, childhood education, science learning, early childhood teacher, playful learning, pedagogical practice, early childhood education, and preschooler
Reoperations as an Outcome Indicator for Developmental Dysplasia of the Hip Treated at Walking Age
Authors: Chang Chia Hsieh , Hung Chi Lun , Lee Wei Chun , Kao Hsuan Kai , Wang Shu Mei , Kuo Ken N.
Published: January 2025

Background:

Reoperation is a major adverse event following surgical treatment but has yet to be used as a primary outcome measure in population studies to assess current treatments for developmental dysplasia of the hip (DDH). The purpose of the present study was to explore the risk factors associated with reoperations following procedures under anesthesia (“operations”) for DDH in patients between the ages of 1 and 3.00 years, with the goal of deriving treatment recommendations.

Methods:

This retrospective birth cohort study included children who had undergone closed reduction, open reduction, or osteotomy for the treatment of unilateral DDH between the ages of 1 and 3.00 years, identified using the Taiwan National Health Insurance Research Database. The children were followed until 10 years of age for reoperations, excluding implant removal and sequential closed reduction within 3 months postoperatively. A comparison between patients with and without reoperations was conducted, and binary logistic regression was used to identify factors associated with reoperation. Patients were further stratified by age and procedure for developing treatment recommendations.

Results:

Among 2,261,455 live births from 2000 to 2009, 701 patients underwent operations for unilateral DDH between 1 and 3.00 years of age (an incidence of 31.0 per 1,000 live births). The initial operations included closed reduction (n = 86; mean age, 1.34 years), open reduction (n = 73; mean age, 1.53 years), pelvic osteotomy (n = 405; mean age, 1.59 years), femoral osteotomy (n = 93; mean age, 1.76 years), and pelvic osteotomy plus femoral osteotomy (n = 44; mean age, 1.84 years). Reoperations were performed in 91 patients (13%) at a mean age of 3.80 years. Comparison between patients with and without reoperations revealed the operative procedure as a significant factor. Logistic regression revealed that closed reduction was associated with a 1.8 to 9.0 times higher reoperation risk than open reduction, depending on age, whereas pelvic osteotomy was associated with 0.34 times the risk of reoperation than open reduction in patients 1.5 to 2.0 years of age.

Conclusions:

Reoperations may not be directly linked to radiographic and functional outcomes but are important from the patient’s perspective and in terms of cost-effectiveness. To reduce the risk of reoperation, the findings of the present study support open reduction to properly reduce the hip joint at walking age and additional pelvic osteotomy for patients beyond 1.5 years of age.

Level of Evidence:

Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.
SISTEM MONITORING SUHU DAN INTENSITAS CAHAYA PADA SOLAR PANEL 3 WP BERBASIS IoT (INTERNET OF THINGS)
Authors: Alfith Alfith , Premadi Aswir , Bachtiar Antonov , Al Habib Sayyid
Published: January 2025

Berdasarkan peta insolasi matahari, wilayah Indonesia memiliki intensitas radiasi harian matahari sebesar 4,8 kW/m per hari. Potensi radiasi matahari sangat berpotensi untuk dimanfaatkan dan merupakan penghasil sumber energi yang paling menjanjikan dimasa mendatang, Energi yang dihasilkan matahari tidak terbatas dibandingkan sumber energi fosil yang semakin menipis. Sudah banyak pakar energi yang bersaing untuk menemukan penemuan baru tentang sumber energi alternatif yang ramah lingkungan, salah satunya yaitu sel surya, walaupun secara efisiensi saat ini masih perlu pertimbangan lebih lanjut. Pada penelitian ini penulis menggunakan modul Wemos dengan tipe ESP 8266 yang dapat terintegrasi dengan system wifi sebagai kontrollernya, serta menggunakan sensor suhu dengan tipe DHT11 untuk mendeteksi suhu pada ruangan dan menggunakan sensor LDR sebagai pendeteksi intensitas cahaya atau sebagai lux yang dapat dimonitoring secara jarak jauh menggunakan koneksi internet. Didapatkan hasil monitoring intesitas cahaya dan suhu dengan nilai intensitas cahaya dan nilai suhu menggunakan penerapkan nilai tertinggi sebesar = 1005 lux, nilai terendah sebesar = 435 lux. Sedangkan untuk nilai tertinggi suhu sebesar= 320 Celcius, untuk terendah sebesar = 240 Celcius, pada kondisi cahaya matahari dalam keadaan puncak, maka nilai yang dihasilkan intensitas cahaya sebesar 1005 lux dan nilai suhu sebesar 32° Celcius yang menandakan bahwa kondisi cuaca sangat panas.
OPTIMASI KUAT TEKAN DAN PENYERAPAN AIR PAVING BLOCK MENGGUNAKAN AKS ADDITIVE
Authors: Mulyati Mulyati , Nurul Fausi Muhammad
Published: January 2025

Penelitian ini menggunakan AKS additive sebagai bahan tambah untuk campuran pembuatan paving block.  Tujuan dari penelitian ini adalah untuk mengetahui nilai kuat tekan dan penyerapan air paving block optimum dari penambahan AKS additive ke dalam bahan campuran pembuatan paving block.  Perbandingan campuran semen dan pasir dalam pembuatan paving block digunakan 1:3, dan penambahan AKS additive 0%, 1,6%, 1,7%, 1,8%, 1,9%, dan 2,0% dari berat semen.  Benda uji paving block menggunakan cetakan dengan ukuran 20 cm x 10 cm x 6 cm.  Pengujian kuat tekan dan penyerapan air paving block dilakukan pada umur 28 hari.  Hasil penelitian menggunakan AKS additive sebagai bahan tambah campuran pembuatan paving block dapat meningkatkan kuat tekan dan menurunkan penyerapan air.  Kuat tekan rata-rata tertinggi sebesar 12,67 MPa dan penyerapan air rata-rata terendah sebesar 7,06% diperoleh pada penggunaan 1,9% AKS additive, memenuhi persyaratan paving block mutu C digunakan untuk trotoar atau pejalan kaki.
SISTEM CERDAS PENDIAGNOSIS KECANDUAN INTERNET YANG MENGGUNAKAN SISTEM PAKAR RUNUT MUNDUR
Authors: Iksan Nur , Yani Achmad , Manaf Abdi , Ismail  , Panessai Ismail Yusuf
Published: January 2025

Bermula sejak COVID19 maka hampir setiap orang di seluruh dunia menggunakan internet bahkan hingga tahap yang mencemaskan yaitu kecanduan internet. Beberapa penelitian melaporkan bahwa tingkat kecanduan terhadap penggunaan jaringan internet semakin tinggi walaupun COVID19 telah reda. Remaja belum mampu memilih aktivitas sambungan internet yang bermanfaat dan mereka lebih mudah mengalami pengaruh buruk lingkungan pergaulan. Untuk mengatasi hal tersebut mereka perlu dukungan dari para psikolog sehingga dapat mencegah dan mendiagnosis dini sebelum mereka menjadi penderita kecanduan internet berat. Namun disisi lain, jumlah psikolog yang dapat membantu masih sangat terbatas terutama di kota-kota kecil. Selain itu faktor ekonomi dan keterbatasan waktu orangtua dalam mendapingi anaknya mengunjugi psikolog menjadi penghambat utama. Oleh karena itu perlu ditemukan solusi yang dapat mengatasi keterbatasan-keterbatasan dan penghambat remaja dalam mendapatkan pelayanan dari seorang psikolog. Salah satu solusi dari permasalahan tersebut adalah membangun sebuah sistem pakar yang dapat bekerja sebagai seorang psikolog. Tujuan penelitian ini adalah untuk membangun sebuah aplikasi sistem pakar untuk melakukan diagnosis kecanduan internet dengan menggunakan metode runut mundur. Tingkat kecanduan internet dikategorikan dalam rendah, sedang dan tinggi. Pengujian sistem dilakukan dengan menggunakan pengujian black box yang memungkinkan pakar memperoleh kumpulan kondisi keluaran yang akan mengerjakan seluruh keperluan fungsional program. Pengujian ini menunjukkan pemasukan data keluaran telah berjalan sebagaimana yang diharapkan.
SISTEM INFORMASI TRANSFUSI DARAH BERBASIS WEB MENGGUNAKAN METODE RAPID APPLICATION DEVELOPMENT
Authors: Nurrohman Muhammad Yusuf , Hardiani Tikaridha , Wijayanto Danur
Published: January 2025

Blood Transfusion at RS PKU Muhammadiyah Gamping faces several issues in the management, administration, and reporting of medical record data, which are still conducted manually. In an effort to comply with the Indonesian Minister of Health Regulation No. 24 of 2022, which requires all healthcare facilities in Indonesia to implement Electronic Medical Records, a Blood Transfusion Information System has been developed. This system is designed to address the problem of medical record storage at RS PKU Muhammadiyah Gamping, which previously relied on paper records stored in file cabinets. The system development uses the Rapid Application Development (RAD) method, chosen for its ability to expedite the system development process. The RAD method involves sequential phases of analysis, design, development, and transition. This research aims to develop an information system that facilitates the administration and reporting of blood transfusions at RS PKU Muhammadiyah Gamping using the CodeIgniter Framework. The system aims to assist nurses in managing and reporting medical record data related to blood transfusions. Testing using the black-box method showed a 100% success rate, indicating excellent performance.Keywords:.Electronic Medical Records, Blood Transfusion Information System, RS PKU Muhammadiyah Gamping, RAD Method, CodeIgniter Framework
ANALISIS KINERJA ALGORITMA PEMBELAJARAN MESIN ENSEMBEL PADA DATASET MULTI KELAS CITRA JAFFE
Authors: Azis Huzain , Alisma Alisma , Purnawansyah Purnawansyah , Nirmala Nirmala
Published: January 2025

This research aims to develop a facial expression recognition system based on the JAFFE dataset which includes seven classes of emotional expressions, namely happy, sad, angry, afraid, disgusted and neutral expressions. The first step taken is canny segmentation on each dataset to maintain essential information on each face. Next, extraction was carried out using the hu moments method to gain an in-depth understanding of the important characteristics of facial expressions. The next process involves ensemble voting using five classification methods, namely Naive Bayes (NB), Support Vector Machine (SVM), K-Nearest Neighbors (KNN), Gaussian Process Classifier (GPC), and Decision Tree. The results of these five methods are then ensembel using voting techniques, and the final results are evaluated using performance metrics such as accuracy, precision, recall, and F-1 score. Evaluation is carried out by comparing the final results with the original data from the JAFFE dataset, by measuring accuracy , precision, recall, and F1 Score value to evaluate system performance. The results of this research show that the ensemble voting approach using a combination of classification methods is able to significantly improve facial expression recognition capabilities. The resulting accuracy, precision, recall, and F1 Score values provide a comprehensive picture of system performance.  This research contributes to the development of facial emotion recognition technology and can be applied in various contexts. Includes human-computer interaction as well as applications in the fields of artificial intelligence.Keywords: Performance Analysis, Ensemble, Jaffe Image, Classification, Multiclass
PERBANDINGAN METODE FUZZY TIME SERIES CHEN DAN METODE EXPONENTIAL SMOOTHING DALAM MEMPREDIKSI CURAH HUJAN DI KABUPATEN PAMEKASAN
Authors: Tamam Moh. Badrit , Kuzairi Kuzairi , Yulianto Toni , Faisol Faisol , Yudistira Ira , Amalia Rica
Published: January 2025

This research aims to predict rainfall in Pamekasan Regency, Madura, East Java, using two prediction methods: Fuzzy Time Series Chen and the Exponential Smoothing (ES) method, specifically Double Exponential Smoothing (DES). The data used in this study consists of monthly rainfall data from January 2011 to December 2023, covering a period of 13 years. The data was sourced from reliable records that regularly track rainfall in the region. In the analysis, both methods were applied to generate accurate predictions of rainfall patterns in Pamekasan Regency. Based on the calculations and performance evaluation, the best method for predicting rainfall in this region was found to be Double Exponential Smoothing Holt. This method uses two key parameters: alpha at 0.4 and beta at 0.6. After applying this method, a Mean Absolute Percentage Error (MAPE) of 1.479 was obtained, indicating a very low and acceptable level of prediction error. Therefore, it can be concluded that the Double Exponential Smoothing Holt method is an effective and accurate approach for predicting rainfall in Pamekasan Regency based on the historical data used..Keywords: Rainfall; Pamekasan Regency; Prediction; Chen's Fuzzy Time Series and Exponential Smoothing (ES) Method
Maternal Plasma Cell-Free RNA as a Predictor of Early and Late-Onset Preeclampsia Throughout Pregnancy
Authors: Garrido-Gómez Tamara , Castillo-Marco Nerea , Cordero Teresa , Igual Marina , Muñoz-Blat Irene , Gómez-Álvarez Carla , Bernat-González Neus , Gaspar-Doménech Ángela , Ortiz-Domingo Érika , Vives Alba , Ortega-Sanchís Sheila , Monfort-Ortiz Rogelio , Volkov Petr , Delgado Juan Luis , Hernandez-Hernandez Laura , Canovas Esther , Gil Maria M , Santacruz Belén , Gonzalez-Gonzalez Nieves Luisa , Plasencia Walter , Perales-Marín Alfredo , Marcos-Puig Beatriz , Palacios Ana , Corcóstegui Iñigo Melchor , Martin-Martinez Alicia , Benitez-Delgado Taysa , Simon Carlos
Published: January 2025

Early-onset (EOPE) and late-onset preeclampsia (LOPE) pose significant challenges to maternal and child health, highlighting the need for early, non-invasive risk identification. In this prospective longitudinal study, we followed 9,586 pregnant women, collecting blood samples each trimester: 9-14 weeks (T1), 18-28 weeks (T2), and after 28 weeks or at preeclampsia diagnosis (T3). Plasma cell-free RNA (cfRNA) signatures were analyzed in women who developed EOPE (n=42) or LOPE (n=43) and compared to matched normotensive controls (n=75). Mapping cfRNA origins and performing differential abundance analysis provided insights into multi-organ impacts, revealing distinct transcriptional features of EOPE and LOPE. We developed a first-trimester EOPE predictive model using 36 transcripts, achieving 83% sensitivity, 88% specificity, and an AUC of 0.85, detecting risk 18.0 weeks before onset. A second-trimester model based on 87 cfRNA transcripts, predicted EOPE 8.5 weeks prior to onset with 87% sensitivity, 84% specificity, and an AUC of 0.85. For LOPE model, detecting risk 14.9 weeks before onset, used 92 cfRNAs, with 86% sensitivity, 89% specificity, and an AUC of 0.88. EOPE models were enriched for decidua-associated transcripts, highlighting the maternal involvement in this subtype, while LOPE models showed diverse tissue responses, paving the way for improved subtype differentiation and tailored interventions to mitigate preeclampsia risks.
Impact of pre-treatment strategies for enhance conversion of Irish Brown Seaweed into high value ingredients using a biorefinery approach.
Authors: Han Yiting , Tan Xinyu , Fitzpatrick Stephen , Lyons Henry , Zhu Xianglu , Tiwari Brijesh K
Published: January 2025

This paper investigates the impact of different pre-treatments on the bio-refinery processes of wild-harvested Irish brown seaweeds, specifically Ascophyllum nodosum and Fucus vesiculosus. Employing a combination of mechanical and chemical methodologies, including drying, soaking, and the application of specific reagents, we aimed to optimize the extraction of valuable polysaccharides such as laminarin, fucoidan, and alginate, alongside protein recovery. The research highlighted the significant influence of pre-treatment methods on extraction efficiencies and polysaccharide purity, indicating that drying is beneficial for improving the purity and yield of laminarin and fucoidan, with laminarin purity as high as 61.46% in Ascophyllum nodosum. The study also demonstrates a complex interplay in alginate extraction across different treatments, with fresh treatments achieving up to 93.15% purity in Fucus vesiculosus. FT-IR provided insight into structural alterations and functional group exposure of extracted polysaccharides, indicating the potential of pre-treatment strategies in enhancing the yield and quality of bioactive compounds. These findings advance our understanding of seaweed bio-refinery processes and underscore the importance of pre-treatment selection in maximizing the sustainable utilization of marine resources for pharmaceutical, nutraceutical, and agricultural applications.
HACD3 promotes the malignant progression of NSCLC by weakening the scaffold between MMK7 and MAPK10
Authors: Xiaoying Wang , Huijun Liang , Qindan Du , ying Li , Yong Zhao
Published: January 2025

Background: HACD3 is from the very long-chain fatty acid dehydratase family and exhibits only mild activity while producing long-chain fatty acids. Numerous studies have uncovered an association of HACD3 with the advancement of diverse cancers. The current study attempts to delve into the potential role of HACD3 in initiating and enhancing lung cancer.
Methods: The study assesses the expression of HACD3 in non-small cell lung cancer (NSCLC) patient samples. Additionally, the effects of HACD3 knockdown and overexpression have been explored on in vitro cell proliferation, colony formation, invasion, migration, and cell cycle progression in lung cancer cells, along with in vivo tumorigenesis inside NSG mice. Furthermore, the current study successfully developed a lung cancer model using HACD3 systemic knockout mice formed using Urethan. Transcriptomics helped identify the target of HACD3 promoting NSCLC progression, followed by validation using different experiments. A truncated plasmid and peptide segment of HACD3 was constructed, followed by screening the specific segment promoting lung cancer progression.
Results: The results demonstrate that HACD3 is highly expressed in cancer tissues and cells while promoting the malignant progression of NSCLC cells. Downregulating HACD3 activates the MAPK pathway in cancer cells. The specific HACD3 fragment promoting cancer progression is located at aa231-259.
Conclusions: The above results indicate that the fatty acid dehydratase HACD3 promotes the malignant progression of lung cancer by suppressing the MAPK pathway. Thus, targeting HACD3 could be a new approach to treating lung cancer.
New Location Algorithm with Primary User Based on Scatter Information in Cognitive Radio
Authors: Ye Dan , Chen Kwang-Cheng
Published: January 2025

In cognitive radio network, if cognitive user conflicts with primary user during the spectrum sensing, it should concede avoiding the effect of communication with primary user. The paper initiates a new sensing method using scatter information around mobile users to locate primary user. The multi-group TOA (Time of Arrival) and AOA (Angle of Arrival) provided by two base stations are measured based on the single reflect statistics channel model under NLOS environment. An innovative location algorithm, proposed in this paper, which combines neural network with the weighted centroid algorithm to achieve primary user’s location. The proposed algorithm can make great improvement on the location accuracy by effectively mitigating NLOS error in cognitive radio networks. Another contribution of the proposed algorithm is the benefit to the cognitive performance which can be characterized by the probability of spectrum coexistence. The results under different simulation circumstances illustrate that the current location algorithm improves detection performance and location performance to obtain more exact probability of spectrum coexistence.
Macrophage efferocytosis controls tissue repair via mitochondrial dynamics in diabetic periodontitis
Authors: Liu Hongrui , Jiang Yujun , Sun Changyun , Guo Jie , Li Minqi
Published: January 2025

Objective
Diabetes induces disorders in macrophage immunometabolism, leading to increased destruction of periodontal tissue. Identifying key factors to restore metabolic alterations and promote resolution of inflammation remains an unmet objective.
Methods
In the present study, the effect of macrophage efferocytosis on inflammatory regression and tissue repair was assessed using diabetic periodontal disease (DPD) model. The mitochondrial function of macrophages cultured under different conditions was assessed in vitro, and macrophage efferocytosis function and polarization phenotypes were examined. Osteogenic differentiation and migration capacity were examined using periodontal ligament stem cells (PDLSCs) co-cultured with macrophages to assess the effect on tissue repair.
Results
We demonstrated that the high-glucose inflammatory microenvironment exacerbated the pro-inflammatory metabolic profile of macrophages and disrupted mitochondrial dynamics. Rats with DPD exhibited heightened periodontal tissue damage during the ligation period, characterized by increased neutrophil infiltration and apoptotic cells. Following ligature removal, the transition to the repair phase was inhibited. Impaired efferocytosis in macrophages led to reduced expression of anti-inflammatory cytokines. Inhibiting excessive mitochondrial division mitigated macrophage damage, ultimately improving the osteogenic differentiation and migration of PDLSCs.
Conclusions
These data suggested the critical role of mitochondria in the resolution of inflammation in diabetic periodontitis through regulating macrophage efferocytosis and interaction with PDLSCs.
FERMENZA ® : A patented bioactive fermented product developed through process optimization
Authors: Ghosh Sudip , Bhattacharya Munna
Published: January 2025

Background: This study investigates the comparative impact of fermentation versus conventional extraction methods on the bioactive potency of "FERMENZA," a patented, affordable, natural fermented cider-based topical formulation.
Methodology and Results: Through comprehensive in vitro analysis, the fermented extract demonstrated superior antioxidant efficacy, with an IC50 value of 0.77 ± 0.03 mg/mL, significantly outperforming solvent and steam-distilled extracts, which showed IC50 values of 2.49 ± 0.01 mg/mL and 4.11 ± 0.03 mg/mL, respectively. Notably, nitric oxide (NO) scavenging activity of the fermented extracts was markedly higher than that of conventional extracts, with IC50 values ranging from 1.12 ± 0.03 to 2.29 ± 0.03 mg/mL. Fermentation also enhanced total phenolic content (TPC), with mixed fruit extracts (pomegranate-beetroot, banana-papaya) reaching TPC levels of 2.43 ± 0.03 mg GAE/g, surpassing individual and conventionally processed samples. The study employed Quality by Design (QbD) approach to optimize fermentation conditions, achieving peak yields of gallic acid (GA) and TPC at 35°C and 72 hours, which further validating the process affordability. Under these conditions, the fermented extracts demonstrated exceptional antimicrobial properties against E. coli, S. aureus, P. aeruginosa, P. acne, and M. furfur, with minimum inhibitory concentration (MIC) values ranging from 0.25 mg/mL to 0.60 mg/mL, superior to those observed in conventionally extracted samples.
Conclusion: These findings highlight the efficacy of fermentation in enhancing bioactive compound availability, positioning FERMENZA® as a potent fermented formulation for probable skin and hair related cosmoceutical applications.
Efficient GPT-4V Level Multimodal Large Language Model for Deployment on Edge Devices
Authors: Yao Yuan , Yu Tianyu , Zhang Ao , Wang Chongyi , Cui Junbo , Zhu Hongji , Cai Tianchi , Chen Chi , Li Haoyu , Zhao Weilin , He Zhihui , Chen Qianyu , Zhou Ronghua , Zou Zhensheng , Zhang Haoye , Hu Shengding , Zheng Zhi , Zhou Jie , Cai Jie , Han Xu , Zeng Guoyang , Li Dahai , Liu Zhiyuan , Sun Maosong
Published: January 2025

The recent surge of Multimodal Large Language Models (MLLMs) has fundamentally reshaped the landscape of AI research and industry, shedding light on a promising path toward the next AI milestone. However, significant challenges remain preventing MLLMs from being practical in real-world applications. The most notable challenge comes from the huge cost of running an MLLM with a massive number of parameters and extensive computation. As a result, most MLLMs need to be deployed on high-performing cloud servers, which greatly limits their application scopes such as mobile, offline, energy-sensitive, and privacy-protective scenarios. In this work, we present MiniCPM-V, a series of efficient MLLMs deployable on edge devices. By integrating the latest MLLM techniques in architecture, pre-training and alignment, the latest MiniCPM-Llama3-V 2.5 has several notable features: (1) Strong performance, outperforming GPT-4V-1106, Gemini Pro and Claude 3 on OpenCompass, a comprehensive evaluation over 11 popular benchmarks, (2) strong OCR capability and 1.8M pixel high-resolution image perception at any aspect ratio, (3) trustworthy behavior with low hallucination rates, (4) multilingual support for 30+ languages, and (5) efficient deployment on mobile phones. More importantly, MiniCPM-V can be viewed as a representative example of a promising trend (Fig. 1): The model sizes for achieving usable (e.g., GPT-4V) level performance are rapidly decreasing, along with the fast growth of edge computation capacity. This jointly shows that GPT-4V level MLLMs deployed on end devices are becoming increasingly possible, unlocking a wider spectrum of real-world AI applications in the near future.
Effectiveness of Low-Cost, Virtual Sexual Health Education and Educational Leaflets on Reducing Anxiety and Enhancing Sexual Function among Infertile Women: A Pilot Randomized Controlled Trial
Authors: Karimi Mahdiyeh , Heshmatnia Fatemeh , Azima Sara , Akbarzadeh Marzieh , Thapa Subash
Published: January 2025

Background and Aims: Anxiety is one of the common mental illnesses affecting sexual functions among infertile women. Information and education interventions might be effective in facilitating their coping with anxiety disorder which lead to improved sexual functions and psychological wellbeing. This is the first trial to pilot-test the effectiveness of sexual health education, delivered through virtual sessions and educational booklets, in improving both psychological (reduced anxiety scores) and physical (increased sexual function) outcomes among women with infertility in Iran.
Methods: In this triple-blind pilot randomized controlled trial, 90 women seeking medical treatment for infertility were randomly divided into three groups: (a) control, (b) educational booklet,and (c) virtual education. Participants in the virtual education group received six sessions of sexual health education through educational video using the WhatsApp social network. The primary outcomes included anxiety and sexual function scores measured before and six weeks after the intervention.
Results: The results showed that, after the intervention, state anxiety scores were significantly lower in the booklet (29.27 ± 4.5, p < 0.001) and virtual education groups (13.77 ± 11.6, p < 0.001) compared with the control (49.26 ± 6.86). Similarly, trait anxiety scores significantly decreased in the booklet (27.03 ± 6.29, p < 0.001) and virtual education groups (31.66 ± 11.63, p < 0.001) compared with the control (45.93 ± 6.52). Post-intervention, there were significant differences between the intervention and control groups in four dimensions of sexual function: sexual desire, sexual stimulation, orgasm, and sexual satisfaction. The virtual education and booklet groups did not show a statistically significant difference in the mean scores of state and trait anxiety, and sexual function.
Conclusion: Psychoeducation interventions via virtual education sessions or educational booklets appear to reduce the level of anxiety and positively affect sexual functions associated with infertility. Women seeking treatment for infertility may benefit from psychoeducational interventions, though further studies with larger sample sizes are needed to confirm these findings.
The Impact of Urbanization on Green Finance Development in Chinese Cities
Authors: Kouam Arthur William Fodouop
Published: January 2025

This study explores the intricate relationship between urbanization dynamics and the development of green finance initiatives in Chinese cities, addressing a critical gap in the existing literature. Utilizing a pragmatic research paradigm, we employed robust quantitative methodologies, including descriptive statistics, correlation analysis, and Ordinary Least Squares (OLS) regression analysis, to evaluate data from 100 urban centers across China. Our empirical model examines how urbanization influences green finance investments and environmental outcomes, highlighting supportive policy environments' mediating role. Key findings reveal a positive correlation between urbanization rates and the development of green finance initiatives, alongside a reciprocal relationship that enhances effective policy formulation. This study contributes original insights into the complexities of urbanization and green finance, demonstrating that green finance alleviates negative environmental impacts and promotes economic resilience. The findings provide practical implications for policymakers, financial institutions, and urban planners, emphasizing the necessity for integrated strategies that foster sustainable development in rapid urban growth.
JEL codes: O18, Q28, R58, H76
Recuperação Sensitiva dos Retalhos Locais para Reconstrução da Polpa Digital
Authors: Leonel Letícia de Freitas , Unser Vinícius , Nascimento Bruno Abdanur Cruz do , Saheb Ricardo Lucca Cabarite , Serrano Sara Dadona Correia , Rezende Luis Guilherme Rosifini Alves
Published: January 2025

Introdução: A recuperação da sensibilidade na polpa dos dedos é muito importante após traumatismos com lesões de partes moles, pois a perda da sensibilidade pode levar a consequências e graves perdas funcionais. O objetivo deste estudo é avaliar a sensibilidade dos retalhos locais utilizados para tratamento de falhas de cobertura da polpa digital. Métodos: Estudo retrospectivo com análise de prontuários, que incluiu pacientes tratados com retalhos locais de avanço ou em ilha em um hospital de nível terciário, no período de março de 2022 a agosto de 2024. A avaliação da sensibilidade foi realizada através da estesiometria e do teste de discriminação estática de 2 pontos. Os dados foram submetidos à análise descritiva e exploratória, com nível de significância de p<0,05. Resultados: Foram avaliados 165 retalhos locais em 154 pacientes de ambos os sexos e com média de idade de 35,1 + 16,9 anos. O tempo médio de seguimento foi de 5,6 + 4,2 meses. 78,8% dos casos foram tratados com retalhos de avanço e 21,2% com retalhos em ilha. Não houve diferença estatisticamente significativa entre os grupos nos resultados da estesiometria e do teste de discriminação estática de 2 pontos. Conclusão: Ambos os tipos de retalho local proporcionaram boa cobertura da polpa digital, com recuperação sensitiva satisfatória e próxima ao normal. Nível de evidência III; estudo de coorte retrospectivo
Analyzing factors influencing SME readiness for smart retail: A structural equation model approach
Authors: Phanitrat Kantaphon , Puriwat Wilert , Hoonsopon Danupol
Published: January 2025

The objective of this study is to explore factors influencing the readiness to enter smart retail businesses. This paper employed a quantitative approach. The sample consisted of 323 retail entrepreneurs in Thailand. Data were collected through questionnaires and analyzed using structural equation modeling (SEM) to verify whether the model constructed in this analysis is consistent, coherent, and suitable for practical application. The influencing factors are as follows: 1) The acceptance and use of technology by entrepreneurs (β = 0.63, p < 0.05), 2) The resource base of entrepreneurs (β = 0.52, p < 0.05), 3) The aspect of business networking by entrepreneurs (β = 0.48, p < 0.05), and 4) The competencies of entrepreneurs (β = 0.40, p < 0.05). These factors significantly affect the readiness to enter the retail market, aligning with empirical data. The structural equation model analysis examines the factors influencing the readiness of small and medium enterprise operators to enter the retail trade. The model meets the specified criteria, as indicated by the following compliance indices: CMIN/df = 2.841, CFI = 0.945, IFI = 0.942, and RMR = 0.036.
AcknowledgmentGratitude is expressed to all the faculty members of the Doctor of Philosophy Program in Technopreneurship and Innovation Management at Chulalongkorn University for imparting valuable knowledge and experience, as well as for their support and encouragement.
Turning Mothers into Freelancers: Is It Fit as Empowerment?
Authors: Arrizqi Dhiya' , Arifianto Chandra Fitra
Published: January 2025

Women's empowerment has become a topic of discussion in efforts to improve the quality of women's welfare. This research explores the role of married women (or mothers) as freelancers in convection companies in South Tangerang. The main focus of this research is to provide an overview of the potential of family workers, especially women, in the context of freelance work. With a qualitative approach, researchers use interviews, observation, and documentation to obtain data. There were four informants, namely mothers who worked as freelancers. Meanwhile, the key informant in this research is the Human Resources Department, which acts as a freelancer recruiter. The questions asked adopted the Multicultural Psychological Empowerment Scale and were in the form of open questions. The analysis technique used is data triangulation. The research results show that empowering women who have families is a process that allows them to have control over their lives and destiny. The empowerment process involves increasing access to employment opportunities and financial independence. It is hoped that the results of this research will provide a comprehensive view of the benefits of women's empowerment for individuals, communities, and society.
MOBILIÁRIO ESCOLAR PARA CRIANÇAS COM PARALISIA CEREBRAL
Authors: Araújo Thalita , Fonsêca de Queiroz Marcelino Juliana , Bezerra Martins Laura
Published: January 2025

O mobiliário escolar adaptado para crianças com Paralisia Cerebral tem sido uma demanda crescente. As áreas da Saúde, Ergonomia e Design formam uma equipe multidisciplinar para que um projeto de um produto inclusivo que satisfaça aspectos técnicos, funcionais e ergonômicos possa ser desenvolvido e a Tecnologia Assistiva é utilizada de diversas formas para realização de adaptações no mobiliário escolar de crianças com Paralisia Cerebral. Dessa forma, este artigo tem como objetivo apresentar a Revisão Sistemática da Literatura com o intuito de compreender como são os mobiliários que estão sendo utilizados para adequar a postura sentada de crianças com Paralisia Cerebral no contexto escolar. Foi utilizado como referência o checklist PRISMA para revisões sistemáticas, e após a aplicação de critérios de inclusão e exclusão, 8 artigos foram incluídos para análise. Os resultados apontaram para o uso crescente de materiais de baixo custo nas adaptações do mobiliário escolar para crianças com Paralisia Cerebral. Foi possível classificar os artigos encontrados em 4 grupos: a) Adaptações em mobiliários sem mesa de apoio; b) Adaptações em mobiliário com mesa de apoio; c) Adaptações em cadeira de rodas sem mesa de apoio; Adaptações em cadeira de rodas com mesa de apoio. Através dos dados obtidos, pode-se observar que diferentes adaptações podem ser realizadas em diversos tipos de mobiliário, respeitando as limitações físicas e funcionais da criança com Paralisia Cerebral.