bluuebunny/crossref_metadata_2025 huggingface dataset:
Sensitive detection of renal cell carcinoma using plasma and urine cell-free DNA methylomes.
Authors: Nuzzo Pier Vitale , Berchuck Jacob E , Spisak Sandor , Korthauer Keegan , Nassar Amin , Abou Alaiwi Sarah , Chakravarthy Ankur , Shen Shu Yi , Bakouny Ziad , Boccardo Francesco , Baca Sylvan , Lee Gwo-Shu Mary , Chang Steven Lee , Waikar Sushrut , Sonpavde Guru , Irizarry Rafael A. , Pomerantz Mark , De Carvalho Daniel , Freedman Matthew L. , Choueiri Toni K.
Published: February 2020

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Background: Improving early cancer detection has the potential to significantly reduce cancer-related mortality. Cell-free methylated DNA immunoprecipitation and high-throughput sequencing (cfMedDIP-seq) is a highly sensitive, low-input, cost-efficient and bisulfite-free assay capable of detecting and classifying various tumor types. We tested the feasibility of cfMeDIP-seq to detect RCC in plasma samples and, for the first time, in urine cell-free DNA (cfDNA), with an emphasis on early-stage disease. Methods: We performed cfMeDIP-seq on 117 samples (72 plasma and 45 urine samples): 68 stage I-IV RCC cases pre-nephrectomy, 21 stage IV urothelial bladder cancer (UBC) plasma samples from 15 patients, and 28 healthy cancer-free controls. 60.5% of plasma samples and 66.7% of urine samples came from patients with TNM Stage I/II disease. cfDNA was immunoprecipitated and enriched using an antibody targeting 5-methylcytosine and amplified to create a sequence-ready library. The top differentially methylated regions (DMRs) which partitioned RCC and control samples or UBC were used to train a regularized binomial generalized linear model using 80% of the samples as a training set. The 20% of withheld test samples were then assigned a probability of being RCC or control. This process was repeated 100 times. This was performed using both plasma and urine cfDNA samples. Results: We identified 89,799 DMRs in plasma samples and 38,462 DMRs in urine samples. Iterative training and classification of held out samples, using the 300 DMRs which partitioned RCC and control samples, resulted in a mean AUROC of 0.990 (95% CI 0.984-0.997) in plasma samples and 0.791 (95% CI 0.759-0.823) in urine samples. Classification performance between tumor types was evaluated comparing plasma cfDNA from patients with RCC and UBC, resulting in a mean AUROC of 0.954 (95% CI 0.940-0.969). Conclusions: cfMeDIP-seq is a powerful tool for genome-wide discovery of non-invasive DNA methylation biomarkers. This is the first independent validation of plasma cfMeDIP-seq, demonstrating near-perfect classification of RCC in a cohort enriched for patients with early-stage disease and the potential of urine cfDNA methylome-based biomarkers for cancer detection.
PT-112 in advanced metastatic castrate-resistant prostate cancer (mCRPC), as monotherapy or in combination with PD-L1 inhibitor avelumab: Findings from two phase I studies.
Authors: Bryce Alan Haruo , Dronca Roxana Stefania , Costello Brian Addis , Infante Jeffrey R. , Ames Tyler David , Jimeno Jose , Karp Daniel D.
Published: February 2020

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Background: PT-112, the first pyrophosphate conjugate in Phase I/II clinical development, induces robust immunogenic cell death and is osteotropic, prompting study in mCRPC during Phase I. We report safety and efficacy findings in the mCRPC sub-population given PT-112 monotherapy (NCT02266745) or in combination with avelumab (“PAVE”) (NCT03409458, ongoing). Methods: Patients (pts) received PT-112 days 1, 8, 15 of a 28d cycle; pts on the PAVE combination also received 800 mg avelumab days 1 and 15; all enrolled during dose escalation or at PT-112 doses previously deemed safe. Pts on therapy (Tx) for ≥2 cycles or who stopped Tx due to progressive disease or treatment-related adverse events (TRAEs) were evaluated for exploratory efficacy. Results: 10 pts on PT-112 (200-420 mg/m2) and 18 pts on PAVE (150-200 mg/m2 PT-112) were evaluable for safety. The most common PT-112 TRAEs were thrombocytopenia (70%, grade (Gr) ≤3) and fatigue (40%, Gr ≤2) with mono-Tx; nausea (50%, Gr ≤2) and fatigue (39%, Gr ≤2) with PAVE. Mono-Tx pts had 6.5 median prior lines of Tx; 2/7 pts with measurable disease (MD) had reductions in target lesions; prostate specific antigen (PSA) declined in 3/10 pts, 1 with ≥50% reduction; and serum alkaline phosphatase (ALP) reductions were seen in 9/10 pts. PAVE pts had 5.5 median prior lines of Tx; radiographic reductions were seen in 2/9 pts with MD; PSA declined in 6/14 pts, 3 with ≥50% decrease, with 1 responder progression free 11.3 months (microsatellite stable). An additional response is ongoing at 4 mos, with 93% PSA decrease and 48% reduction in target lesions (PIK3CBmut & PTEN loss). 13/14 pts with bone metastases had ALP reductions. Pain improvement, opioid cessation and improved performance status were noted in both cohorts. Conclusions: PT-112 was well-tolerated with evidence of efficacy in mCRPC as mono-Tx and in combination with avelumab in heavily pre-treated pts. Bone pain improvement and nearly universal observation of ALP reduction suggest marked therapeutic activity of PT-112 in bone metastases. Serologic / RECIST responses and prolonged disease control in multiple pts substantiate further development of PT-112 in mCRPC. Clinical trial information: NCT02266745, NCT03409458.
Human factors and safety in endoscopy
Authors: Ravindran Srivathsan , Thomas-Gibson Siwan
Published: February 2020

Human factors are prevalent in healthcare and can impact on patient outcomes. Defining and understanding human factors is a key aspect of improving patient safety. Human factor issues can manifest as active and latent failures that impact on wider safety systems. This article outlines two cases that highlight the importance of human factors in endoscopy and defines learning points that can be applied in practice. Safety in endoscopy has classically been defined in simple terms and through hard outcomes, such as mortality. However, it is known that within endoscopy patient safety incidents are common and they may not all necessarily lead to harm. These are often difficult to measure, and there is a growing understanding of the complexities of safety measurement. Additionally, there are increasing challenges to promoting safety in modern-day endoscopy, due to increasing numbers and complexities of patients and procedures. A novel national strategy has been designed to address these challenges and promote a positive shift to improving safety in endoscopy.
Beta blockers in the perioperative period
Authors: Prince Mark
Published: February 2020

The cardiovascular effects of beta blockers are widespread, so their use in the perioperative period ought to be beneficial, although this is not clear cut. This article discusses the evidence for and against the use of beta blockers perioperatively and gives guidance for best practice.
Research roundup: February 2020
Authors: Seal Joanne , Odd Dawn
Published: February 2020

In this section, a range of brief synopses of recently published articles that may be of interest to health visitors is presented. The aim of this roundup is to provide an overview, rather than a detailed summary, of the research papers selected. Should you wish to look at any of the papers in more detail, a full reference is provided.
Can air pollution be fatal for children with asthma?
Authors: Hancock David
Published: February 2020

A landmark court case could determine whether air pollution contributed to the death of a 9-year-old girl with severe asthma. How polluted is the air we breathe and what effect could it be having on children with respiratory problems? David Hancock finds out
Common standards for education
Authors: Oldman Crystal
Published: February 2020

The Nursing and Midwifery Council announced in January that it will review the standards of proficiency for specialist community public health nursing programmes. What will this mean for health visitors?
Semiconductor Detectors for Observation of Multi-MeV Protons and Ions Produced by Lasers
Authors: Krása J. , Klír D. , De Marco M. , Cikhardt J. , Velyhan A. , Řezáč K. , Pfeifer M. , Krouský E. , Ryć L. , Dostál J. , Kaufman J. , Ullschmied J. , Limpouch J.
Published: February 2020

The application of time-of-flight Faraday cups and SiC detectors for the measurement of currents of fast ions emitted by laser-produced plasmas is reported. Presented analysis of signals of ion detectors reflects the design and construction of the detector used. A similarity relation between output signals of ion collectors and semiconductor detectors is established. Optimization of the diagnostic system is discussed with respect to the emission time of electromagnetic pulses interfering with signals induced by the fastest ions accelerated up to velocities of 107 m/s. The experimental campaign on laser-driven ion acceleration was performed at the PALS facility in Prague.
Demonstratives as indicators of interactional focus: Spatial and social dimensions of Spanish esta and esa
Authors: Shin Naomi , Hinojosa-Cantú Luis , Shaffer Barbara , Morford Jill P.
Published: February 2020

This paper adopts a cognitive linguistic framework to explore the influence of spatial and social factors on the use of Spanish demonstratives esta ‘this’ and esa ‘that’. Twenty adult Spanish speakers in Monterrey, Mexico, were asked questions prompting the selection of puzzle pieces for placement in a 25-piece puzzle located in the shared space between the participant and an addressee. Although participants were not explicitly instructed to produce demonstratives, the need to identify specific puzzle pieces naturally elicited a total of 523 tokens of esta and esa. Analyses of the distribution of esta versus esa show that demonstratives are not used in a categorical manner to mark differences in physical space. Although participants tended to produce proximal esta for referents near the speaker, both esta and esa were used for referents further from the speaker and closer to the addressee. Participants’ demonstrative selection was also influenced by interaction type: intersubjective misalignment between speakers promoted the use of proximal esta, whereas intersubjective alignment promoted the use of distal esa. These results support the view that nominal grounding is an intersubjective activity. Physical and social factors jointly shape speakers’ construal of the developing co-constructed communicative event as a whole, leading to increasingly variable usage of demonstratives as the referent is more distant both spatially and intersubjectively from the speaker.
The shear and compressive yield stress of fibrillated acacia pulp fiber suspensions
Authors: Sha Jiulong , Yang Yueyue , Wang Can , Li Wei , Lu Peng , Qin Chengrong , Wang Shuangfei
Published: February 2020

The degree of interactions between fibers and the tendency of fibers to form flocs play an important role in effective unit operation in pulp and paper industry. Mechanical treatments may damage the structure of the fiber cell wall and geometrical properties, and ultimately change the fiber-fiber interactions. In this study, the gel crowding number, compressive and shear yield stress of fibrillated acacia pulps were investigated, and the results showed that the gel crowding number of the refined pulp samples ranged from 8.7 to 10.7, which were much lower than that of un-refined pulps. As the concentration increased, both the compressive yield stressPy{P_{y}}and shear yield stressτy{\tau _{y}}of all suspensions increased accordingly, and the yield stress was found to depend on a power law of the crowding number. Moreover, the values ofτy/Py{\tau _{y}}/{P_{y}}were also examined and the variation ofτy/Py{\tau _{y}}/{P_{y}}became largely dependent on the fiber morphology and mass concentration.
Al3Ti/ADC12 Composite Synthesized by Ultrasonic Chemistry in Situ Reaction
Authors: Sun Yong-Hui , Yan Hong , Xiong Jun-Jie
Published: February 2020

Al3Ti/ADC12 composite was synthesized in situ using Al-fluoride potassium titanate (K2TiF6) as the reaction system and an ultrasonic assisted direct melt reaction. Results indicate ultrasonic chemistry reactions are both accelerated and more complete compared to traditional in situ reactions. Al3Ti reinforced particles with a regular shape and size of 1-2 μm were well distributed and as-cast microstructures of composites were superior. Composite particles under ultrasonic assistance were also refined to a greater extent. Tensile strength and elongation rate of the composites reached 255 MPa and 2.2%, an increase of 19.1% and 37.5% respectively to those without ultrasonic aid. Cleavage surface of the composite declined and the number of dimples increased while dimples became smaller and deeper, showing obvious ductile fracture.
The Embedded Health Management Academic: A Boundary Spanning Role for Enabling Knowledge Translation Comment on "CIHR Health System Impact Fellows: Reflections on ‘Driving Change’ Within the Health System"
Authors: Eljiz Kathy , Greenfield David , Taylor Robyn
Published: February 2020

Healthcare organisations are looking at strategies and activities to improve patient outcomes, beyond clinical interventions. Increasingly, health organisations are investing significant resources in leadership, management and team work training to optimise professional collaboration, shared decision-making and, by extension, high quality services. Embedded clinical academics are a norm in, and considered a strength of, healthcare organisations and universities. Their role contributes, formally and informally, to clinical teaching, knowledge sharing and research. An equivalent, but significantly less common role, addressing the management of healthcare organisations, is the embedded health management academic (EHMA). A stimulus encouraging this intertwined embedded academic role, in both clinical and managerial fields, is the demand for the translation of knowledge between academic and industry contexts. In this essay, we describe the EHMA role, its value, impact and potential for enabling healthcare organisation improvement. Focusing on the business of healthcare, the EHMA is a conduit between sectors, stakeholders and activities, enabling different organisations and experts to co-create, share and embed knowledge. The value and impact achieved is significant and ongoing, through the nurturing of an evidence-based management culture that promotes ongoing continuous improvement and research activities.
Patients’ Coping Behaviors to Unavailability of Essential Medicines in Primary Care in Developed Urban China
Authors: Wu Dan , Lam Tai Pong , Lam Kwok Fai , Sun Kai Sing , Zhou Xu Dong
Published: February 2020

Background: China rolled out the national essential medicines policy (NEMP) in primary care in 2009 and led to some unintended consequences including unavailability of essential medicines. This study examined patients’ coping behaviors to these unintended consequences of NEMP as well as the potential impact on primary care system development in Hangzhou, a developed city of China. Methods: We conducted qualitative interviews and surveys with service users, primary care physicians (PCPs), and specialists in tertiary hospitals. Qualitative findings informed the design of the survey questionnaires. Main outcomes included patients’ coping behaviors after the NEMP implementation, as well as providers’ perceptions of NEMP’s impact on primary care development. Thematic analysis of the qualitative data and descriptive analysis of the survey data were conducted. Results: Unintended effects of NEMP included frequent unavailability of certain essential drugs, leading to patient flow from primary care to hospital outpatient clinics for drug refills, difficulties in the provision of continuing care in primary care, as well as compromised patient trust in PCPs. In total, 1248 service users completed the questionnaires. A total of 132 (10.6%) were aged 60 years or above. Among 153 (57.7%) of the 265 who had some chronic condition(s) and needed long-term medication treatment, 60.1% went to hospitals for refills. Four-hundred sixty PCPs and 651 specialists were recruited. Among 404 PCPs who were aware of the NEMP policy implementation in their facility, 169 (41.8%) reported that there was often a shortage of drugs at their facilities and 44 (10.9%) reported always. Moreover, 68.6% of these PCPs thought that the NEMP could not meet their patients’ needs. Further, 44.2% (220/498) of specialists who were aware of the NEMP policy in primary care reported that they often heard patients complaining about the policy. In total, 53.1% of PCPs and 42.4% of specialists disagreed that NEMP helped direct patient flow to community-based care. Conclusion: NEMP’s unintended effects undermined patients’ utilization of primary care in a developed city in China and led to unnecessary hospital visits. Countermeasures are needed to mitigate the negative impacts of NEMP on the primary care system.
ÇORUM YÖRESİ BALLARININ BAZI KİMYASAL KALİTE PARAMETRELERİNİN DEĞERLENDİRİLMESİ
Authors: GÜZEL Nihal , BAHÇECİ K. Savaş
Published: February 2020

Bu araştırma, Çorum yöresi ballarının bazı kalite parametrelerinin belirlenmesi amacıyla gerçekleştirilmiş olup temin edilen 47 bal örneğinde pH, çözünür kuru madde, nem, serbest asitlik, HMF, kül, elektriksel iletkenlik, diastaz sayısı, şeker oranı gibi pek çok kalite parametresi değerlendirilmiştir. Ortalama değerler göz önüne alındığında pH 3.83 (3.55-4.20), çözünür kuru madde 81.5°Bx (76.8-83.8), nem %16.9 (14.5-21.7), serbest asitlik 32.2 meq/kg (21.1-47.8), HMF 3.5 mg/kg (0.3-36.5), kül %0.18 (0.02-1.58), elektriksel iletkenlik 350 µS/cm (205-674), diastaz sayısı 16.4 (0.1-32.2), glukoz %30.4 (26.0-34.3), fruktoz %35.3 (31.5-39.1), sukroz %0.34 (<0.05-4.64), glukoz ve fruktoz toplamı %65.8 (57.5-73.4) ve fruktozun glukoza oranı ise 1.16 (1.03-1.24) şeklinde sonuçlar elde edilmiştir. Bu veriler, genel olarak bal örneklerinin Türk Gıda Kodeksi Bal Tebliği’nde belirtilen yasal limitlere uygunluğunu ortaya koymaktadır. Bununla birlikte bir örnek nem ile glukoz ve fruktoz toplamı, üç örnek ise diastaz sayısı bakımından söz konusu mevzuata uymamaktadır.
Large-Scale Transgenic Drosophila Resource Collections for Loss- and Gain-of-Function Studies
Authors: Zirin Jonathan , Hu Yanhui , Liu Luping , Yang-Zhou Donghui , Colbeth Ryan , Yan Dong , Ewen-Campen Ben , Tao Rong , Vogt Eric , VanNest Sara , Cavers Cooper , Villalta Christians , Comjean Aram , Sun Jin , Wang Xia , Jia Yu , Zhu Ruibao , Peng Ping , Yu Jinchao , Shen Da , Qiu Yuhao , Ayisi Limmond , Ragoowansi Henna , Fenton Ethan , Efrem Senait , Parks Annette , Saito Kuniaki , Kondo Shu , Perkins Liz , Mohr Stephanie E , Ni Jianquan , Perrimon Norbert
Published: February 2020

The Transgenic RNAi Project (TRiP), a Drosophila melanogaster functional genomics platform at Harvard Medical School, was initiated in 2008 to generate and distribute a genome-scale collection of RNA interference (RNAi) fly stocks. To date, it has generated >15,000 RNAi fly stocks. As this covers most Drosophila genes, we have largely transitioned to development of new resources based on CRISPR technology. Here, we present an update on our libraries of publicly available RNAi and CRISPR fly stocks, and focus on the TRiP-CRISPR overexpression (TRiP-OE) and TRiP-CRISPR knockout (TRiP-KO) collections. TRiP-OE stocks express single guide RNAs targeting upstream of a gene transcription start site. Gene activation is triggered by coexpression of catalytically dead Cas9 fused to an activator domain, either VP64-p65-Rta or Synergistic Activation Mediator. TRiP-KO stocks express one or two single guide RNAs targeting the coding sequence of a gene or genes. Cutting is triggered by coexpression of Cas9, allowing for generation of indels in both germline and somatic tissue. To date, we have generated >5000 TRiP-OE or TRiP-KO stocks for the community. These resources provide versatile, transformative tools for gene activation, gene repression, and genome engineering.
Kryptoverwahrung nach dem KWG: Der Versuch einer Konturierung des neuen Erlaubnistatbestands
Authors: Resas Daniel , Ulrich Niklas , Geest André
Published: February 2020

Deutschland hat die Umsetzung der Änderungsrichtlinie zur Vierten EU-Geldwäscherichtlinie zum Anlass genommen, im Alleingang die Verwahrung von Kryptowerten als Finanzdienstleistung einer Erlaubnispflicht nach dem KWG zu unterstellen. In der praktischen Rechtsanwendung zeigt sich jedoch, dass der Tatbestand des Kryptoverwahrgeschäfts nicht zuletzt durch die komplexe technische Materie eine Reihe von (Abgrenzungs-)Fragen aufwirft, die die Verwaltungs- und Beratungspraxis noch länger beschäftigen werden.
Linear Modelling of The State-Wise Yield of Principal Crops in India
Authors: P Gayathri  , K R Subramanian
Published: February 2020

Modelling techniques are applied in agriculture field. Yield of rice is modelled using the method of least squares in Time Series Analysis and linear equations are fitted for the state-wise average yield of crops in kg per hectare in India and also for the average yield of various principal crops in Tamil Nadu.
Bounds For The Complex Part of Phase Velocity
Authors: S Sridevi  , V Ganesh  , R Thenmozhy
Published: February 2020

We study incompressible, inviscid, density stratified fluid with variable cross section in this present paper. For this problem, we have obtained a bound for the complex part of phase velocity. Furthermore, we have obtained an instability region which depends on number of parameters.
On Color Energy of Few Classes of Bipartite Graphs and Corresponding Color Complements
Authors: Prajakta Bharat Joshi  , Mayamma Joseph
Published: February 2020

For a given colored graph G, the color energy is defined as Ec(G) = Σλi, for i = 1, 2,…., n; where λi is a color eigenvalue of the color matrix of G, Ac (G) with entries as 1, if both the corresponding vertices are neighbors and have different colors; -1, if both the corresponding vertices are not neighbors and have same colors and 0, otherwise. In this article, we study color energy of graphs with proper coloring and L (h, k)-coloring. Further, we examine the relation between Ec(G) with the corresponding color complement of a given graph G and other graph parameters such as chromatic number and domination number.

AMS Subject Classification: 05C15, 05C50
The Development of Teaching Materials on Integrated Science, Technology, and Religion to Improve College Students’ Integrative Knowledge
Authors: Nasir Muhammad , Yuliani Hadma , Nastiti Luvia Ranggi
Published: February 2020

The purposes of this study were (1) to determine the specifications of teaching materials integrated STR; and (2) to analyze the results of expert validation to teaching materials integrated STR. The research method used in this study was Research and Development (R D) with a four-D procedure (Define, Design, Develop, and Disseminate). The data analysis technique used was descriptive analysis techniques. The results of the study show that (1) The profile of the teaching materials integrated STR are (a) teaching materials are integration between concepts of fundamental of physics and Islamic values of Al-Quran and Hadith ; and (b) the media developed is an integration between PPT and Phet; and (2) The results of the material expert validation on the results of the development of teaching materials integrated STR on aspects of content feasibility, aspects of presentation, aspects of language, and material integration are well categorized. Likewise, the results of media expert validation on the display and programming aspects show good categories
HPLC–DAD method for investigating pantoprazole for its stress-dependent degradation by photolysis and oxidation
Authors: Al Bratty Mohammad , Thangavel Neelaveni , Peraman Ramalingam , Kumar Vinod , Reddy Padmanabha , Nagappan Krishna Veni , Al Hazmi Hassan
Published: February 2020

A reversed-phased high-performance liquid chromatography–diode-array detection (HPLC–DAD) method has been developed for investigating the stress-dependent degradation of pantoprazole (PTZ) by a photolytic and oxidative mechanism. The developed method separated PTZ from its degradation products on a C18 column with a mobile phase consisted of methanol and water (60:40, v/v; pH 3.0) at a flow rate of 1 mL/min. The linear regression coefficient of 0.9995 was obtained for a concentration range from 5 to 25 μg/mL. The % relative standard deviation for repeatability and intermediate precision were below 0.5% and 1.5%, respectively, while the sensitivity of the method was demonstrated by a limit of detection value of 0.25 μg/mL. The stress sample analyses for PTZ results revealed the formation of a total of 18 degradation products, and out of them, 9 degradation products were common for both photolytic and oxidative degradations. Further, the oxidation by azobisisobutyronitrile produced the highest number of degradation products (11 impurities), 3 of which are more hydrophobic than PTZ. In photolytic degradation, 8 and 7 degradation products were observed with UV radiation and sunlight exposure, respectively. Furthermore, the degradation of pantoprazole sodium injection formulation was carried out under the same stress conditions, and it revealed the formation of 3 common impurities under both stress conditions, but other impurities were not detected in the formulations. Finally, 3 common impurities formed in formulations of PTZ injections, viz., sulfone, N-oxide, and N-oxide sulfone impurities, were identified by spike analyses.
Self-Organizing B2B Enterprise of Distributed Photogrammetric Processing of Terrain Images in ETRIS
Authors: Karsaev Oleg , Shuklin Igor , Yushchenko Sergey
Published: February 2020

An approach to the dynamic formation (adjustment) of schedules for distributed photogrammetric image processing in a network of ground centers included in the United geographically distributed information system for receiving and processing Earth remote sensing data from space is considered. Having the fullest satisfaction of requirements of consumers to the satellite images of necessary areas, the approach provides the formation of self-organizing B2B enterprises in the specified network providing information, software and hardware resources of the ground-based facilities of various departmental and other accessories for photogrammetric processing of any received images of the area from the the United geographically distributed information system. It is shown, that a search in B2B enterprise nodes and borrowing the required resources will allow ground centers to flexibly scale physical and virtual means of photogrammetric processing of Earth remote sensing data, quickly form their local structural and functional organizations depending on the current properties of the consumer requests flow for receiving Earth remote sensing data in the United geographically distributed information system, characteristics of the flow of terrain survey materials from orbital monitoring tools, and also take into account the visual and measuring properties of images of the area subject to photogrammetric processing. A method for truncating the set of potential performers of the application in accordance with the existing semantic and other restrictions on the composition of the desired set of performers is proposed. Also mechanisms to encourage ground centers to provide idle resources to B2B enterprise nodes are proposed. They are based on the possibility of receiving monetary or other remuneration from a ground center for participating in distributed application servicing. The development of a well-known model of a self-organizing B2B enterprise creates conditions for a more efficient organization of servicing the flow of applications in the United geographically distributed information system by attracting unused software, information and hardware resources of ground centers of various departmental affiliations.
Identité, langues et savoirs dans Riwan ou le chemin de sable de Ken Bugul
Authors: Fopa Kuete Roger
Published: February 2020

This paper, which draws its analytic and hermeneutic postulate from epistemocriticism, studies the mechanism of renegotiation of identity in Ken Bugul’s Riwan ou le chemin de sable (Riwan, or the Sandy Path). It demonstrates that the narrator decides to return to her native land because she is afraid of losing connection with herself. The study analyses the return to native land not as a withdrawal to one’s identity but as a kind of poetizing of one of many various ways of life found within contemporary Senegalese society. The paper explores different forms of representation in cultural Senegalese knowledge through the perspectives of savoir-être (knowledge of how to behave) and savoir-dire (knowledge of how to express) which take into account taboo and customary rituals. These articulations of traditional knowledge are the keys from which the narrator reconnects with her origins and thus manages to reconstruct her ethnic identity.
L’Annonce faite à Marie: de l’héritage africain à une lecture postcoloniale
Authors: Ahondoukpe Mireille
Published: February 2020

In this article, a postcolonial reading is undertaken of L’annonce faite à Marie (The annunciation of Mary), a 1912 play by Paul Claudel. Several celebrated authors from Africa and the Caribbean, belonging to the black postcolonial world, willingly acknowledge their debt to Paul Claudel, including Aimé Césaire, Léopold Sédar Senghor, Édouard Glissant and Saint-John Perse. Nevertheless, postcolonial theories generally exclude the study of Western and medieval works from the purview of postcolonial studies. It may thus appear paradoxical to propose a postcolonial reading of Claudel’s play, written by a French playwright who does not belong to the colonized world. The play is furthermore set in the Middle Ages. However, many critics, mostly Anglo-Saxons, have successfully matched medieval texts and postcolonial studies. In fact, postcolonial theoretical tools are capable of casting new light on the study of L’Annonce faite à Marie, regarding, for example, relations of gender or power, marginalization and migration. Given Claudel’s avowed impact on the literature of the black world, in view of the play’s focus on situations of domination, the postcolonial approach may be legitimately applied to the study of L’Annonce faite à Marie, despite the ‘medieval’ particularities of this play.
Lost in Translation: The Implementation of Community Service in Lebanese High-schools Following Decree No.8924
Authors: Mouchantaf Maha
Published: February 2020

In 2012, the Lebanese Ministry of Education and Higher Education (MEHE) issued Decree No. 8924. Entitled “Project Community Service in Public and Private Secondary Schools”, the decree states that all schools should apply a mandatory 60-hour community service program across the three secondary school years. There have been scattered efforts to study how the Decree is being implemented across Lebanon, with no exhaustive and thorough study yet documented. This research sought to fill part of that gap by examining the experience of ten private Catholic schools. The research results were congruent with global educational policy implementation research and suggested future lines of inquiry specific to Lebanon.
Lexical and Phonological Differences in Javanese in Probolinggo, Surabaya, and Ngawi, Indonesia
Authors: Kartikasari Erlin , Larasati Diyas Age , Rais Wakit A. , Warto Warto
Published: February 2020

This study aims to reveal part of language components named lexical and phonological differences in Javanese in East Java, Indonesia. Data were collected from a sample of three regions which are Probolinggo, Surabaya, and Ngawi. Probolinggo was chosen because of its adjacency to Madura Island. Surabaya was chosen because of its strategic location not only the centre of government, but also as the Capital City of East Java Province. Meanwhile, Ngawi was chosen because of its location in the west-end of East Java and directly adjacent to Central Java Province. This research is a quantitative research. The data were Javanese used by adults in East Java, especially in Probolinggo, Surabaya, and Ngawi. The research instrument used was Nothofer questionnaire which was modified by Kisyani to be 829 glossaries of words/phrases. The results of the study revealed that: 1) the most lexical of Javanese was in the western and eastern parts of East Java thus the least was in the central government of East Java Province, Surabaya, 2) lexical differences in Javanese in Probolinggo, Surabaya, and Ngawi result in one dialect and two sub dialects, and 3) phonological differences in Javanese in Probolinggo, Surabaya, and Ngawi produced three utterances.
Interplay of Fantasy and Realism in Salman Rushdie’s Midnight’s Children
Authors: Khan Mohsin Hassan , Zaini Qudsia , Hossain Md Jakir
Published: February 2020

Fantasy and realism are the traits to be found in every culture and individual. Fantasy was often dismissed for being a thing associated with children. This was a practice found to be rampant in the past or it was rather a matter of the past so to say. After centuries of oblivion, people have started giving importance to fantasy when there is a lot of chaos in the society. Fantasy as a genre that helps us to band together, explain, change and form an opinion on reality. Fantasy can surely tempt the human desire, for more than the familiar world of the readers, into ease, anyway from reality and communicate with immense imagination that the readers can connect to. With this in mind, the paper tries to analyze Rushdie’s Midnight’s Children the bizarre and the fantastic blurs the boundaries between the real and plausible in the novel, thereby problematizing the identities of gender, parenthood, and nationality, and renders the readers into a state of uncertainty by incorporating oblique references or links. It also aims to critically analyze and discuss how the lines between fantasy and reality are blurred in literature. The importance of this study is to connect the fine line of fantasy with reality in literature and to present perceptions to the readers on how literature is understood differently by different people.
A construção da identidade do aluno frente ao projeto lei de ideologia de gênero
Authors: Almeida Maiara Cristine Oliveira de , Vale Carolina Sena do , Silva Cristiano Cezar Gomes da
Published: February 2020

RESUMO: O presente trabalho traz uma breve discussão acerca dos conceitos de ideologia, gênero e identidade a partir do debate a respeito da identidade do aluno frente ao projeto lei de ideologia de gênero. No decorrer do trabalho, tais conceitos foram correlacionados ao projeto lei de ideologia de gênero com a construção de identidade do aluno. Foram mobilizados autores, como: Althusser (1995), Arroyo (2004), Carvalho (2011), Foucault (1988), Hall (2005), Louro (2007), Souza e Silva (2018) e Silva (2017), além de algumas normas legais. Do ponto de vista metodológico, foram realizadas análises bibliográficas, para, a partir das leituras, trazer elementos para a presente discussão. Destaca-se que a escola deve possibilitar o desenvolvimento do pensamento crítico a partir da compreensão sobre as diferenças corporais e sexuais que culturalmente se constroem na sociedade, tendo papel fundamental na desmistificação dessas diferenças, além de ser um importante instrumento na construção de valores e atitudes, que permitam um olhar mais crítico e reflexivo sobre as identidades de gênero e sexual. Nesse sentido, este trabalho visa suscitar o debate e a reflexão sobre a ideologia de gênero na construção da identidade a partir da escola.

PALAVRAS-CHAVE: ideologia de gênero; identidade; escola.
A marca do tropeirismo e os caminhos do gado em Alagoas
Authors: Ferreira José Robson Gonçalves , Leite Angela Maria Araújo
Published: February 2020

RESUMO: A plantation, no nordeste brasileiro, é introduzida após a invasão portuguesa, no início do século XVI. O cultivo da cana de açúcar vai ser inserido na zona da mata e os engenhos vão se espalhando pelo território canavieiro. Para dar suporte a esses engenhos, a produção de alimentos se desenvolverá no agreste e a pecuária bovina no sertão, dessa forma o interior vai sendo ocupado, especialmente no atual território alagoano. Será a partir desta abordagem que o presente trabalho se desenvolverá. O objetivo é apresentar resultados da primeira etapa de uma pesquisa sobre a formação das cidades, através de levantamentos documentais em cartórios, igrejas e órgãos públicos. Assim, constatou-se a importância do tropeirismo, que será fundamental para o surgimento das feiras livres e, consequentemente, das cidades do agreste. Da mesma forma, as fazendas de gado serão o marco inicial da ocupação dos municípios do sertão alagoano.

PALAVRAS-CHAVE: Tropeiro. Rio dos currais. Agreste. Sertão. Alagoas.
™Índice de germinação (IG) e índice de velocidade de germinação (IVG) do tomate cereja (Solanum lycopersicum var. cerasiforme, solanaceae) cultivadas em vasos sob diferentes substratos
Authors: Silva Luiz Francisco Tavares da , Lira Thaynnara Paula dos Santos , Araújo Victória Polyana Azevedo , Barbosa Lívia Gibrinde , Lima Letícia Paula Barros , Barros Rubens Pessoa de
Published: February 2020

RESUMO: Objetivou-se com este estudo avaliar os índices de germinação (IG) e de velocidade de germinação (IVG) do Tomate Cereja (Solanum lycopersicum var. cerasiforme) em diferentes substratos em ambiente protegido. A área da pesquisa foi na casa de vegetação da Universidade Estadual de Alagoas, Campus I, em Arapiraca-AL durante o período de Março a abril/2019. Os substratos utilizados foram areia fina, areia lavada, solo de área agrícola e Bioplant®. A semeadura ocorreu em vasos em material plástico, e foram realizadas sendo 5 repetições em cada tipo de solo, totalizando 20 amostras. Foram analisados o IG e o IGV de cada amostra no período de 30 dias. Foi possível identificar que o tomate cereja apresentou melhor IG e IGV nos substratos Areia Fina e Bioplant.

PALAVRAS-CHAVE: desenvolvimento, sementes, solo.
Envelhecimento e educação: impressões advindas da oficina pedagógica de formação
Authors: Barbosa Edja Souza , Silva Maria Lays da , Araújo Mariana Ferreira Torres de , Bezerra Sara Jane Cerqueira
Published: February 2020

RESUMO: Trata-se de relato da experiência da execução da Oficina Pedagógica Envelhecimento e Educação: tecendo caminhos possíveis no curso de Pedagogia do Campus III da Universidade Estadual de Alagoas. A Oficina teve como objetivo articular o conhecimento teórico do que seja envelhecimento tanto a nível médico quanto a nível psicológico, em um ambiente de formação de professores, tendo como meta a conscientização do que é ser idoso.  A oficina foi desenvolvida em três momentos: palestra; participação de idosas e circuito do envelhecimento. Com a realização desta experiência as autoras afirmam que, frente às mudanças sociais e o aumento da população idosa, a pedagogia torna-se ciência propícia para interlocução de ações que deem visibilidade às necessidades dessa parcela da população. Ressaltam ainda o grande ganho da educação com a alteração na LDBEN 9394/96 através da Lei nº 13.632/2018 que acrescentou um inciso no artigo 37, garantindo a educação ao longo da vida, no cotidiano social e em diferentes espaços educacionais.

PALAVRAS-CHAVE: Educação; Envelhecimento; Gerontologia Educacional.
Relação campo-cidade e dinâmicas populacionais no município de Jaramataia-Alagoas.
Authors: Lima Júnior Admilton Barbosa , Amaral Guilherme Alves do , Nunes Maria Vitória Barbosa , Lima Noêmia Fernanda Azarias , Oliveira Matteus Freitas de
Published: February 2020

RESUMO: O município de Jaramataia, localizado no Sertão de Alagoas, possui uma população de 5.558 habitantes (IBGE, 2010) e nele são estabelecidas relações campo-cidade mediadas pela articulação de fluxos que emergem dos seus espaços urbanos e rurais. O município é composto por sete povoados e um assentamento, apresentando cadeias produtivas ligadas à produção de leite, pescado e agricultura de subsistência temporal e permanente nos moldes do trabalho sustentável/familiar. Face ao exposto, o objetivo desta pesquisa foi compreender as dinâmicas populacionais que se estabelecem entre a sede de Jaramataia e as áreas onde se concentram os principais fluxos dessas cadeias produtivas que estão situadas no perímetro rural. Para além disso, o estudo coloca na agenda de análise a realidade de cidades pequenas que mantêm a complexa relação com o campo por meio da agricultura. Metodologicamente, foi realizado levantamento bibliográfico com base nas palavras-chave cidade-campo, cidade pequena, cadeia produtiva e agroindústria, e, em seguida, foram elaborados e aplicados questionários semiestruturados, e, por fim, procedeu-se à análise dos dados.

PALAVRAS-CHAVE: Cidades pequenas, Sertão alagoano, Rural-urbano.
“A batalha urbana para além do nome”: segregação urbana entre os Bairros Alto São Jorge e Avenida Governador Muniz Falcão, na cidade de Batalha-AL
Authors: Nobre Larissa Emanuely Silva , Farias Ana Raquel dos Santos , Aquino Heloisy Mafalda Vieira , Costa Sarah de Souza , Sales Artur Ferreira , Oliveira Matteus Freitas de
Published: February 2020

RESUMO: O presente trabalho procurou analisar a segregação socioespacial que ocorre na cidade de Batalha, em Alagoas, comparando os bairros Avenida Governador Muniz Falcão e o Bairro Alto São Jorge. Foram verificados os arranjos espaciais e o perfil socioeconômico de seus moradores como marcadores da paisagem urbana, além de identificar os agentes que atuam modelando esses espaços e gerando formas e funções específicas na cena da urbe. Metodologicamente, a pesquisa foi realizada por meio de levantamento de literatura, dados primários oriundos de questionários e entrevistas semiestruturadas. Constatou-se que, mesmo sendo um fenômeno na escala da cidade pequena, os processos decorrentes do modo de produção capitalista nas cidades do ocidente reproduzem as mesmas lógicas de desigualdade e produção dialética das diferenças, intensificando as lutas e a segregação no cotidiano da cidade.

PALAVRAS-CHAVE: Cidade pequena, Capitalismo, Agentes produtores.
Averamientu al estudiu sociollingüísticu d'un criptolectu gremial: el bron de Miranda
Authors: Carballo López Alba
Published: February 2020

Los miembros de determinados grupos de artesanos desarrollaron, históricamente, sistemas lingüísticos secretos conocidos como jergas gremiales. Estas jergas han sido objeto de diversos estudios, pero nunca se les había prestado atención desde el punto de vista de la sociolingüística. Aquí se propone adoptar este enfoque para el estudio de una de las jergas gremiales asturianas: el bron de Miranda (Avilés). Con ello se pretende constatar tanto el nivel de pervivencia, y hasta qué punto determinados elementos lingüísticos se transfieren al habla común, como el conjunto de valoraciones sociales en torno a la jerga.
Trabajo independiente interdisciplinar en programas académicos de contabilidad y finanzas
Authors: Chaveco Libia Bermúdez , Teope Romero Misleidis , Rodríguez Garcel Esnaidel
Published: February 2020

La independencia cognitiva del estudiante implica procesos de resignificación pedagógica, centrados en el trabajo independiente y autónomo de naturaleza interdisciplinar, que se corresponda con el modelo de profesional concebido en la educación superior. Desde esta perspectiva la mediación didáctica centrada en la tarea del docente, resulta un proceso clave para la dirección del trabajo independiente. En este artículo, se caracterizan los componentes estructurales y dinámica funcional de una propuesta didáctica orientada a fortalecer el desarrollo del trabajo independiente interdisciplinario, de manera que se propicie el desarrollo humano y social de los estudiantes. El fundamento metodológico se organiza en atención a secuencias didácticas que atienden la lógica del proceso de construcción de conocimiento; por ello se cubren etapas de diagnóstico, formulación, orientación y evaluación de la actividad independiente interdisciplinar en el ámbito de la enseñanza, en programas académicos de Contabilidad y Finanzas. Entre los resultados destaca que, la selección de núcleos estructurantes por disciplina permite la formulación coherente de trabajo independiente interdisciplinar. Se concluye que la propuesta de secuencias didácticas garantiza una adecuada y flexible estructuración de los nexos disciplinarios, constituye una alternativa válida y pertinente para el trabajo de los colectivos pedagógicos que convergen en la construcción de los espacios cognitivos interdisciplinarios.
Scheduling of Student-development Activities via an Integration of Compromised-AHP and Transportation Model
Authors: Nazri Engku Muhammad , Ahmad Norazura , Shariffuddin Mohd Dino Khairri
Published: February 2020

One of the main challenges to schedule student-development activities in a university is to avoid time conflicts that may affect participation from the students. This can be achieved by having a proper planning and scheduling of student-development activities. In this paper, we demonstrate how Compromised-Analytic Hierarchy Process (C-AHP) and 0-1 Integer Programming (0-1 IP) models were utilized to schedule a set of student activities to be run by the UUMâ€™s Student Body for the 2018/2019 academic year. The C-AHP was used to determine the activity-month preference values, while 0-1 IP models were constructed to schedule a set of student activities that can be executed successfully with high participation rates from the students. Two different 0-1 IP models, which can be viewed as transportation models: Model A and Model B were constructed. Model A was formulated without the month preference to conduct the activities, whereas Model B took consideration on the month preference. For Model A, the optimal result indicated that the activities scheduled were concentrated towards the earlier months of the academic year. On the other hand, the scheduling of activities provided by Model B was better-spread across the months of the academic year. The methods applied in this study will be useful to be implemented by organizations with many subunits in the management of planned activities in order to avoid time conflicts among activities, which in turn will minimize the chances of activity failure.
Actitudes, percepciones y prácticas de docentes de preescolar hacia el trabajo con familias homoparentales en Bogotá
Authors: Hermosa Bosano Carlos Alberto , Vargas-Trujillo Elvia , Ripoll Núñez Karen
Published: February 2020

Menos del 30% de la población en Colombia está de acuerdo con que las parejas del mismo sexo adopten. Este clima de rechazo trae interrogantes sobre las experiencias de las familias homoparentales existentes en el país. Debido a la importancia de los años preescolares para el desarrollo de niños y niñas, este estudio tuvo como objetivo describir las actitudes, percepciones y prácticas de 53 docentes de prescolar en Bogotá con relación al trabajo con familias homoparentales. El análisis de las encuestas revela actitudes caracterizadas por preocupación ante la potencial victimización a la que pueden estar expuestos los hijos de estas familias. Así mismo, se encontró que los docentes, si bien afirman sentirse competentes, reconocen que con baja frecuencia implementan estrategias para construir climas escolares incluyentes. Los resultados permiten recomendar el desarrollo de iniciativas de formación para docentes para que, desde los primeros años de educación formal, los miembros de familias homoparentales cuenten con entornos afirmativos de la diversidad.