bluuebunny/crossref_metadata_2025 huggingface dataset:
Preliminary Study on Phytochemical Constituents and Biological Activities of Essential Oil from Myriactis nepalensis Less.
Authors: Fu Jikai , Gao Yang , Xing Xiang
Published: July 2022

In response to the need for novel therapeutic strategies to combat the development of microbial resistance, plant essential oils may represent a promising alternative source. This study set out to characterize the chemical composition and assess the antibacterial potential of Myriactis nepalensis Less. essential oil (MNEO). Essential oil isolated from M. nepalensis by hydrodistillation was analyzed using a GC–MS technique. The antibacterial properties of MNEO alone and combined with antibiotics (chloramphenicol and streptomycin) were tested via the disc diffusion, microbroth dilution, and checkerboard methods. MNEO was represented by oxygenated sesquiterpenes (60.3%) and sesquiterpene hydrocarbons (28.6%), with caryophyllene oxide, spathulenol, humulene epoxide II, β-elemene, neointermedeol, and β-caryophyllene as the main compounds. MNEO exhibited a strong antibacterial effect against Gram-positive bacteria, with MIC and MBC values of 0.039 mg/mL and 0.039–0.156 mg/mL, respectively, and synergistic effects were observed in both combinations with chloramphenicol and streptomycin. Furthermore, the antibiofilm and cytotoxic activities of MNEO were also evaluated. The crystal violet assay was used for quantification of Staphylococcus aureus biofilm formation, and an MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) assay was conducted to determine cell viability. The results revealed MNEO could dose-dependently inhibit Staphylococcus aureus biofilm formation and possessed potential cytotoxic on both normal and cancer cells (IC50 values from 13.13 ± 1.90 to 35.22 ± 8.36 μg/mL). Overall, the results indicate that MNEO may have promising applications in the field of bacterial infections.
Folate-Targeted Curcumin-Loaded Niosomes for Site-Specific Delivery in Breast Cancer Treatment: In Silico and In Vitro Study
Authors: Honarvari Banafsheh , Karimifard Sara , Akhtari Niyayesh , Mehrarya Mehrnoush , Moghaddam Zahra Salehi , Ansari Mohammad Javed , Jalil Abduladheem Turki , Matencio Adrián , Trotta Francesco , Yeganeh Faten Eshrati , Farasati Far Bahareh , Arki Mandana Kazem , Naimi-Jamal Mohammad Reza , Noorbazargan Hassan , Lalami Zahra Asghari , Chiani Mohsen
Published: July 2022

As the most common cancer in women, efforts have been made to develop novel nanomedicine-based therapeutics for breast cancer. In the present study, the in silico curcumin (Cur) properties were investigated, and we found some important drawbacks of Cur. To enhance cancer therapeutics of Cur, three different nonionic surfactants (span 20, 60, and 80) were used to prepare various Cur-loaded niosomes (Nio-Cur). Then, fabricated Nio-Cur were decorated with folic acid (FA) and polyethylene glycol (PEG) for breast cancer suppression. For PEG-FA@Nio-Cur, the gene expression levels of Bax and p53 were higher compared to free drug and Nio-Cur. With PEG-FA-decorated Nio-Cur, levels of Bcl2 were lower than the free drug and Nio-Cur. When MCF7 and 4T1 cell uptake tests of PEG-FA@Nio-Cur and Nio-Cur were investigated, the results showed that the PEG-FA-modified niosomes exhibited the most preponderant endocytosis. In vitro experiments demonstrate that PEG-FA@Nio-Cur is a promising strategy for the delivery of Cur in breast cancer therapy. Breast cancer cells absorbed the prepared nanoformulations and exhibited sustained drug release characteristics.
Preliminary Evaluation of Iron Oxide Nanoparticles Radiolabeled with 68Ga and 177Lu as Potential Theranostic Agents
Authors: Salvanou Evangelia-Alexandra , Kolokithas-Ntoukas Argiris , Liolios Christos , Xanthopoulos Stavros , Paravatou-Petsotas Maria , Tsoukalas Charalampos , Avgoustakis Konstantinos , Bouziotis Penelope
Published: July 2022

Theranostic radioisotope pairs such as Gallium-68 (68Ga) for Positron Emission Tomography (PET) and Lutetium-177 (177Lu) for radioisotopic therapy, in conjunction with nanoparticles (NPs), are an emerging field in the treatment of cancer. The present work aims to demonstrate the ability of condensed colloidal nanocrystal clusters (co-CNCs) comprised of iron oxide nanoparticles, coated with alginic acid (MA) and stabilized by a layer of polyethylene glycol (MAPEG) to be directly radiolabeled with 68Ga and its therapeutic analog 177Lu. 68Ga/177Lu- MA and MAPEG were investigated for their in vitro stability. The biocompatibility of the non-radiolabeled nanoparticles, as well as the cytotoxicity of MA, MAPEG, and [177Lu]Lu-MAPEG were assessed on 4T1 cells. Finally, the ex vivo biodistribution of the 68Ga-labeled NPs as well as [177Lu]Lu-MAPEG was investigated in normal mice. Radiolabeling with both radioisotopes took place via a simple and direct labelling method without further purification. Hemocompatibility was verified for both NPs, while MTT studies demonstrated the non-cytotoxic profile of the nanocarriers and the dose-dependent toxicity for [177Lu]Lu-MAPEG. The radiolabeled nanoparticles mainly accumulated in RES organs. Based on our preliminary results, we conclude that MAPEG could be further investigated as a theranostic agent for PET diagnosis and therapy of cancer.
Band Structure Near the Dirac Point in HgTe Quantum Wells with Critical Thickness
Authors: Shuvaev Alexey , Dziom Vlad , Gospodarič Jan , Novik Elena G. , Dobretsova Alena A. , Mikhailov Nikolay N. , Kvon Ze Don , Pimenov Andrei
Published: July 2022

Mercury telluride (HgTe) thin films with a critical thickness of 6.5 nm are predicted to possess a gapless Dirac-like band structure. We report a comprehensive study on gated and optically doped samples by magnetooptical spectroscopy in the THz range. The quasi-classical analysis of the cyclotron resonance allowed the mapping of the band dispersion of Dirac charge carriers in a broad range of electron and hole doping. A smooth transition through the charge neutrality point between Dirac holes and electrons was observed. An additional peak coming from a second type of holes with an almost density-independent mass of around 0.04m0 was detected in the hole-doping range and attributed to an asymmetric spin splitting of the Dirac cone. Spectroscopic evidence for disorder-induced band energy fluctuations could not be detected in present cyclotron resonance experiments.
All-Solution Processed Single-Layer WOLEDs Using [Pt(salicylidenes)] as Guests in a PFO Matrix
Authors: Germino José Carlos , Duarte Luís Gustavo Teixeira Alves , Mendes Rodrigo Araújo , Faleiros Marcelo Meira , de Morais Andreia , de Freitas Jilian Nei , Pereira Luiz , Atvars Teresa Dib Zambon
Published: July 2022

Herein, we report the synthesis and characterization of two Pt(II) coordination compounds, the new platinum(II)[N,N′-bis(salicylidene)-3,4-diaminobenzophenone)] ([Pt(sal-3,4-ben)]) and the already well-known platinum(II)[N,N′-bis(salicylidene)-o-phenylenediamine] ([Pt(salophen)]), along with their application as guests in a poly [9,9-dioctylfluorenyl-2,7-diyl] (PFO) conjugated polymer in all-solution processed single-layer white organic light-emitting diodes. Completely different performances were achieved: 2.2% and 15.3% of external quantum efficiencies; 2.8 cd A−1 and 12.1 cd A−1 of current efficiencies; and 3103 cd m−2 and 6224 cd m−2 of luminance for the [Pt(salophen)] and [Pt(sal-3,4-ben)] complexes, respectively. The Commission Internationale de l’Eclairage (CIE 1931) chromaticity color coordinates are (0.33, 0.33) for both 0.1% mol/mol Pt(II):PFO composites at between approximately 3.2 and 8 V. The optoelectronic properties of doped and neat PFO films have been investigated, using steady-state and time-resolved photoluminescence. Theoretical calculations at the level of relativistic density functional theory explained these results, based on the presence of the Pt(II) central ion’s phosphorescence emission, considering spin-orbit coupling relationships. The overall results are explained, taking into account the active layer morphological properties, along with the device’s electric balance and the emitter’s efficiencies, according to deep-trap space-charge models. Considering the very simple structure of the device and the ease of synthesis of such compounds, the developed framework can offer a good trade-off for solution-deposited white organic light-emitting diodes (WOLEDs), with further applications in the field of lighting and signage.
Antioxidants Derived from Natural Products Reduce Radiative Damage in Cultured Retinal Glia to Prevent Oxidative Stress
Authors: Cliver Richard N. , Castro Natalia , Russomano Thais , Lardieri Gaetano , Quarrie Lindsay , van der Merwe Helena , Vazquez Maribel
Published: July 2022

Retinal pathologies have been heavily studied in response to radiation and microgravity, including spaceflight-associated neuro-ocular syndrome (SANS), which is commonly developed in space flight. SANS has been characterized in clinical studies of astronauts returning to Earth and includes a range of symptoms, such as globe flattening, optic-disc edema, retinal folds, and retinal ischemia. In cases of retinal insult, Müller glia (MG) cells respond via neuroprotective gliotic responses that may become destructive to produce glial scarring and vison loss over time. Retinal pathology is further impacted by the production of excessive reactive oxygen species (ROS) that stimulate retinal inflammation and furthers the gliosis of MG. Neuroprotectants derived from natural products (NPs) able to scavenge excess ROS and mitigate long-term, gliotic responses have garnered recent interest, especially among mature and aging adults. The natural antioxidants aloin and ginkgolide A flavonoids, derived from Aloe vera and Ginkgo biloba species, respectively, have been of particular interest due to their recent use in other nervous-system studies. The current study examined MG behaviors in response to different doses of aloin and ginkgolide A over time by measuring changes in morphology, survival, and ROS production within microscale assays. The study was further enhanced by using galactic cosmic rays (GCR) at the Brookhaven NASA Space Radiation Laboratory to simulate ionizing radiation in low- and high-radiation parameters. Changes in the survival and ROS production of radiation-treated MG were then measured in response to varying dosage of NPs. Our study used in vitro systems to evaluate the potential of NPs to reduce oxidative stress in the retina, highlighting the underexplored interplay between NP antioxidants and MG endogenous responses both in space and terrestrially.
Advances in the Immunobiology of Parasitic Diseases
Authors: Morales-Montor Jorge , McKay Derek M. , Terrazas Luis I.
Published: July 2022

Notwithstanding that most biomedical research today focuses on the pandemic caused by the SARs-CoV-2 virus, there are many unresolved diseases that are almost forgotten worldwide [...]
A Retrospective Study of the Efficacy of Albendazole and Diethylcarbamazine for the Treatment of Human Toxocariasis
Authors: Magnaval Jean-François , Fillaux Judith , Berry Antoine
Published: July 2022

In the Department of Parasitology and Mycology of Toulouse University Hospitals, patients presenting with common/covert toxocariasis were treated either with albendazole (39 cases) or with diethylcarbamazine (32 cases). Albendazole (ABZ) was given at 10 mg/kg b/w daily for 14 days, and diethylcarbamazine (DEC) was given at 4 mg/kg b/w daily for 21 days. In both groups, follow-up consultations occurred approximately 48 days after the end of the anthelmintic therapy. ABZ and DEC displayed a similar efficacy on the kinetics of the clinical picture (−64.5% of reduction vs. −72.7%, respectively) and on the levels of blood eosinophilia, serum eosinophil cationic protein and serum total IgE. However, the effect of the medication on the laboratory parameters was moderate. The rate of adverse reactions was similar in both groups (38% for ABZ vs. 31% for DEC), but DEC-treated patients complained of more intense and long-lasting side effects. The DEC group had more major adverse reactions, resulting in the termination of the anthelmintic treatment. The results from this retrospective study bring further arguments for considering ABZ, given at 10 mg/kg daily for 2 weeks, as the drug of choice in the treatment of human toxocariasis.
A Rapid Method for Detecting Normal or Modified Plant and Algal Carbonic Anhydrase Activity Using Saccharomyces cerevisiae
Authors: Rai Ashwani K. , DiMario Robert J. , Kasili Remmy W. , Groszmann Michael , Cousins Asaph B. , Donze David , Moroney James V.
Published: July 2022

In recent years, researchers have attempted to improve photosynthesis by introducing components from cyanobacterial and algal CO2-concentrating mechanisms (CCMs) into terrestrial C3 plants. For these attempts to succeed, we need to understand the CCM components in more detail, especially carbonic anhydrase (CA) and bicarbonate (HCO3−) transporters. Heterologous complementation systems capable of detecting carbonic anhydrase activity (i.e., catalysis of the pH-dependent interconversion between CO2 and HCO3−) or active HCO3− transport can be of great value in the process of introducing CCM components into terrestrial C3 plants. In this study, we generated a Saccharomyces cerevisiae CA knock-out (ΔNCE103 or ΔCA) that has a high-CO2-dependent phenotype (5% (v/v) CO2 in air). CAs produce HCO3− for anaplerotic pathways in S. cerevisiae; therefore, the unavailability of HCO3− for neutral lipid biosynthesis is a limitation for the growth of ΔCA in ambient levels of CO2 (0.04% (v/v) CO2 in air).  ΔCA can be complemented for growth at ambient levels of CO2 by expressing a CA from human red blood cells. ΔCA was also successfully complemented for growth at ambient levels of CO2 through the expression of CAs from Chlamydomonas reinhardtii and Arabidopsis thaliana. The ΔCA strain is also useful for investigating the activity of modified CAs, allowing for quick screening of modified CAs before putting them into the plants. CA activity in the complemented ΔCA strains can be probed using the Wilbur–Anderson assay and by isotope exchange membrane-inlet mass spectrometry (MIMS). Other potential uses for this new ΔCA-based screening system are also discussed.
Physiological Studies and Ultrastructure of Vigna sinensis L. and Helianthus annuus L. under Varying Levels of Nitrogen Supply
Authors: Alharbi Khadiga , Haroun Samia A. , Kazamel Amany M. , Abbas Mohammed A. , Ahmaida Safia M. , AlKahtani Muneera , AlHusnain Latifa , Attia Kotb A. , Abdelaal Khaled , Gamel Rasha M. E.
Published: July 2022

This experiment was conducted to investigate the effects of different nitrogen fertilizers (potassium nitrate and/or urea) on shoot parameters, relative growth rate, net assimilation rate, and nitrogen fractions, as well as to conduct transmission electron microscopy, of Vigna sinensis L. (cowpea) and Helianthus annuus L. (sunflower) leaves. A general improvement was recorded in the shoot parameters of the two plants, except for a decrease in the net assimilation rate by treatment of the two plants with 100% potassium nitrate plus 100% urea. The total nitrogen, insoluble protein, and total soluble nitrogen generally decreased in cowpea shoots from the treatments but increased in case of cowpea roots and sunflower shoots and roots. The examination of the ultrastructure changes in cowpea leaves confirmed the presence of two starch granules (in response to 100% potassium nitrate, 100% potassium nitrate plus 100% urea, and the control) and three granules (in response to 50% potassium nitrate plus 50% urea) and the disappearance of the starch granules (in response to 100% urea). Despite the starch granules not being detected in the leaves of the untreated sunflower, the treated plant showed the appearance of the highest number after treatment with 50% potassium nitrate plus 50% urea (2) and the most cell size with the 100% potassium nitrate treatment. Generally, our findings demonstrated that fertilization with 50% potassium nitrate plus 50% urea has the best influence on the growth parameters and nitrogen content in the two plants, but the magnitude of response was more pronounced in case of cowpea plants.
Identification of Spring Wheat with Superior Agronomic Performance under Contrasting Nitrogen Managements Using Linear Phenotypic Selection Indices
Authors: Iqbal Muhammad , Semagn Kassa , Céron-Rojas J. Jesus , Crossa José , Jarquin Diego , Howard Reka , Beres Brian L. , Strenzke Klaus , Ciechanowska Izabela , Spaner Dean
Published: July 2022

Both the Linear Phenotypic Selection Index (LPSI) and the Restrictive Linear Phenotypic Selection Index (RLPSI) have been widely used to select parents and progenies, but the effect of economic weights on the selection parameters (the expected genetic gain, response to selection, and the correlation between the indices and genetic merits) have not been investigated in detail. Here, we (i) assessed combinations of 2304 economic weights using four traits (maturity, plant height, grain yield and grain protein content) recorded under four organically (low nitrogen) and five conventionally (high nitrogen) managed environments, (ii) compared single-trait and multi-trait selection indices (LPSI vs. RLPSI by imposing restrictions to the expected genetic gain of either yield or grain protein content), and (iii) selected a subset of about 10% spring wheat cultivars that performed very well under organic and/or conventional management systems. The multi-trait selection indices, with and without imposing restrictions, were superior to single trait selection. However, the selection parameters differed quite a lot depending on the economic weights, which suggests the need for optimizing the weights. Twenty-two of the 196 cultivars that showed superior performance under organic and/or conventional management systems were consistently selected using all five of the selected economic weights, and at least two of the selection scenarios. The selected cultivars belonged to the Canada Western Red Spring (16 cultivars), the Canada Northern Hard Red (3), and the Canada Prairie Spring Red (3), and required 83–93 days to maturity, were 72–100 cm tall, and produced from 4.0 to 6.2 t ha−1 grain yield with 14.6–17.7% GPC. The selected cultivars would be highly useful, not only as potential trait donors for breeding under an organic management system, but also for other studies, including nitrogen use efficiency.
Stimulation of Germination of Freshly Collected and Cold-Stored Seeds of Ambrosia artemisiifolia L.
Authors: Šćepanović Maja , Košćak Laura , Pismarović Laura , Šoštarčić Valentina
Published: July 2022

Herbicides are the most commonly used means of controlling the growth of Ambrosia artemisiifolia L. Their constant use has led to the development of resistant populations. They can be evaluated by studying seed germination and the corresponding grown plants, but A. artemisiifolia exhibits seed dormancy, preventing germination and delaying research. Here, we developed a simple and rapid method to stimulate germination of freshly collected or stored A. artemisiifolia seeds. The germination of A. artemisiifolia freshly collected/stored seeds was evaluated after storage, stratification, and chemical treatments (ethephon, gibberellic acid (GA3), thiourea, KNO3). Ethephon or ethephon + GA3 improved freshly collected seed germination by 88 and 95%, respectively, and germination of stored seeds by 78 and 80%, respectively. In addition, placing the seeds of A. artemisiifolia in ethephon, GA3, ethephon + GA3, or thiourea solutions caused the freshly collected seeds to germinate faster than stored seeds or nontreated seeds. In contrast, the conditioning of seeds in these solutions favored germination of stored seeds, especially when ethephon + GA3 or GA3 was used. Imbibition of the freshly collected A. artemisiifolia seeds in a mixture of ethephon and GA3 can effectively overcome primary dormancy when rapid experimental results are needed. For seeds requiring prolonged storage, conditioning in ethephon, GA3, or thiourea solutions may be applied to promote germination.
Study on Speed Planning of Signalized Intersections with Autonomous Vehicles Considering Regenerative Braking
Authors: Li Ning , Yang Jiarao , Jiang Junping , Hong Feng , Liu Yang , Ning Xiaobin
Published: July 2022

In order to reduce the energy consumption caused by the frequent braking of vehicles at signalized intersections, an optimized speed trajectory control method is proposed, based on braking energy recovery efficiency (BERE) in connection with an automated system for vehicle real-time interaction with roadside facilities and regional central control. Our objectives were as follows; firstly, to establish the simulation model of the hybrid energy regenerative braking system (HERBS) and to verify it by bench test. Secondly, to build up the genetic algorithm (GA) optimization model for the deceleration stopping of the HERBS. Then, to obtain signal light status and timing information to be the constraints; the BERE is to be the optimized objective, resulting in optimization for the speed trajectory under the deceleration stopping condition of a single signalized intersection. Finally, vehicle simulations in ADVISOR software are utilized to validate the optimization results. The results show that the BERE during deceleration stopping at a single signalized intersection after the speed trajectory optimization is 36.21% higher than that of inexperienced drivers, and 7.82% higher than that of experienced drivers.
Regenerable Kiwi Peels as an Adsorbent to Remove and Reuse the Emerging Pollutant Propranolol from Water
Authors: Gubitosa Jennifer , Rizzi Vito , Fini Paola , Nuzzo Sergio , Cosma Pinalysa
Published: July 2022

This work aims to characterize the adsorption process of propranolol HCl, an emerging pollutant and a widely used β-blocker, onto kiwi peels, an agricultural waste. The use of UV-vis spectroscopy was considered to obtain information about the pollutant removal working in the in-batch mode. In a relatively short time, the adsorption process could remove the pollutant from water. A kiwi peel maximum adsorption capacity of 2 mg/g was obtained. With the perspective of scaling up the process, preliminary in-flux measurements were also performed. The investigation of the whole in-batch adsorption process was conducted by studying the effect of ionic strength (adopting salt concentrations from 0 to 0.4 M), pH values (from 2 to 12), adsorbent/pollutant amounts (from 25 to 100 mg and from 7.5 to 15 mg/L, respectively), and temperature values (from 289 to 305 K). The thermodynamics, the adsorption isotherms, and the kinetics of the adsorption process were also carefully investigated. The Langmuir model fitted the experimental data well, with an R2 of 0.9912, restituting KL: 1 L/mg and Q0: 1.8 mg/g. The temperature increase enhanced the pollutant removal due to the endothermic adsorption characteristics. Accordingly, a ΔH°298K of +70 KJ/mol was obtained. The pseudo-first-order kinetic model described the process. Due to the results observed during the study of the effects of pH and ionic strength, the prominent presence of electrostatic interactions, working in synergy with hydrophobic forces and H-bonds between the pollutant and kiwi peel surfaces, was successfully demonstrated. In particular, FTIR-ATR measurements confirmed the latter findings. Finally, desorption experiments for recycling 100% of propranolol for each cycle were performed using 0.1 M MgCl2. Ten cycles of adsorption/desorption were obtained and indicated that the percentage of propranolol removal was not affected during each run, increasing the maximum adsorption from 2 to 20 mg/g.
Use of 2-Ethylhexyl Nitrate for the Slow Pyrolysis of Plastic Waste
Authors: Uebe Jochen , Zukauskaite Audrone , Kryzevicius Zilvinas , Vanagiene Gintare
Published: July 2022

Plastics are widely used and are part of modern life. Recycling of plastic waste can be achieved by pyrolysis. Conventional pyrolysis of plastic waste takes place at temperatures higher than 450 °C, because the oil yield is higher. In this study, we examined if an initiator for radical reactions can achieve the conventional pyrolysis of HDPE and PP even at low temperatures. To support the onset of decomposition of HDPE and PP at low temperatures, 2-ethylhexyl nitrate (2-EHN) was added. 2-EHN forms radicals already at about 150 °C and can thus initiate the pyrolysis process at lower temperatures. Pyrolysis oil yields increased, especially for HDPE pyrolysis, at the expense of the gaseous (minus 50%) and especially the solid fraction (minus 80%). For PP and HDPE pyrolysis oil, the proportion of carbon compounds shifted toward shorter-chain, less cyclic compounds, and there was an improvement in the physicochemical property profile: the heating values of both oils were slightly higher and the pour point significantly lower, in line with the shift toward shorter-chain compounds. The diesel content and, to a lesser extent, the gasoline content increased at the expense of waxes and other high-boiling compounds.
The Lautsi Legacy: A New Judgment on the Crucifix in Classrooms and the Multiculturalist Turn on Freedom of/from Religion in Italy
Authors: Breskaya Olga , De Stefani Paolo , Giordan Giuseppe
Published: July 2022

The article offers a socio-legal analysis of the recent case on freedom of/from religion in Italy, the Coppoli judgment of the Italian Supreme Court, which grants public schools the autonomy to manage religious symbols. The new ruling is discussed in the shadow of the Lautsi case, examining the shift from the discourse of “passive religious symbol” to the framework of “respect of different sensibilities” in pluralistic classrooms. In doing that, first, we provide a sociological framework for the study of “passive religious symbols” from a multiculturalist and religious freedom perspective. Second, the Coppoli case is contextualized within political, normative and judicial Italian contexts following the Lautsi jurisprudence. Third, we revise the model of “secularism as a method of dialogue” considered by the judges as important in claiming individual freedoms of/from religion in the multicultural classroom. The final part of the article provides a discussion and critical considerations about the Coppoli case, problematizing the future challenges of managing religious diversity in Italian public schools. We argue that the dynamic of freedom of/from religion’s jurisprudence in the Coppoli case endorses an additive model of accommodating diverse cultural and religious identities in public schools.
The Human Rights Situation of Intersex People: An Analysis of Europe and Latin America
Authors: Mestre Yessica
Published: July 2022

Today, intersex people of Europe and Latin America are subjected to different degrees of invisibility and discrimination for being part of bodily diverse communities. Thus, these experiences have been addressed as violations of intersex human rights. This research intends to explore intersex human rights across Europe and Latin America through a scoping review and legal research, including the review of activist documents. It seeks to study the experiences of violence suffered by intersex people, the role of states in promoting justice, and the possibilities offered by a human rights framework to guarantee a dignified life for bodily diverse communities. This research also illustrates that, although regional, cultural and social landscapes differ in both continents, intersex groups are subject to constant violations of their human rights, and they struggle for recognition and for their bodies to be respected outside the binary categories of sex and gender. Furthermore, European and Latin American states have made proven legislative advances that have led to the greater visibility of intersex people but also face remaining difficulties and gaps.
Integrating Multiscale Geospatial Environmental Data into Large Population Health Studies: Challenges and Opportunities
Authors: Cui Yuxia , Eccles Kristin M. , Kwok Richard K. , Joubert Bonnie R. , Messier Kyle P. , Balshaw David M.
Published: July 2022

Quantifying the exposome is key to understanding how the environment impacts human health and disease. However, accurately, and cost-effectively quantifying exposure in large population health studies remains a major challenge. Geospatial technologies offer one mechanism to integrate high-dimensional environmental data into epidemiology studies, but can present several challenges. In June 2021, the National Institute of Environmental Health Sciences (NIEHS) held a workshop bringing together experts in exposure science, geospatial technologies, data science and population health to address the need for integrating multiscale geospatial environmental data into large population health studies. The primary objectives of the workshop were to highlight recent applications of geospatial technologies to examine the relationships between environmental exposures and health outcomes; identify research gaps and discuss future directions for exposure modeling, data integration and data analysis strategies; and facilitate communications and collaborations across geospatial and population health experts. This commentary provides a high-level overview of the scientific topics covered by the workshop and themes that emerged as areas for future work, including reducing measurement errors and uncertainty in exposure estimates, and improving data accessibility, data interoperability, and computational approaches for more effective multiscale and multi-source data integration, along with potential solutions.
Evaluación de zona urbana educativa ante amenazas de riesgo de inundación. Río Portoviejo
Authors: Giraldo García Carlos Luis , Anchundia Loor Andrés Miguel
Published: July 2022

La gestión de riesgo permite minimizar los efectos negativos, en un territorio y su población vulnerable, frente a los desastres que se puedan originar de forma natural o por actividad humana, cuyo objetivo es identificar las principales amenazas y los posibles riesgos a los que puede estar expuesta las unidades educativas   frente a eventos adversos entre ellos las inundaciones. Se realizó un estudio descriptivo transversal en la zona urbana educativa antes amenazas de riesgo de inundación del Río Portoviejo. Las variantes utilizadas fueron vulnerabilidad, amenaza, capacidad de respuestas y nivel de conocimiento. Resultados: los personales docentes en su mayoría tienen conocimientos regulares sobre gestión de riesgos y primeros auxilios, con respecto a la capacitación de los docentes solamente 41.6 % se han capacitado en prevención y respuesta de emergencia. Concluyéndose en la Notoria ausencia de política de gestión de riesgo y de un sistema de gestión que involucre un accionar de riesgo

 

Palabras claves: zona urbana, unidad educativa, gestión de riesgo – prevención, desastres
REPROGRAMACIÓN DEL LÁSER DE TERAPIA
Authors: Figueredo Núñez Arian , Rivero Roger , Escobar Sandy , Andrial Yolanda , Giralt Angela
Published: July 2022

The low power laser has been used with great therapeutic success in many of the medical specialties. The effectiveness of this therapy is based on the contribution of sufficient energy so that through its absorption and transformation in the tissues the therapeutic process can be generated. The LASERMED 830/670 DL NEW is a modern equipment designed for low power laser therapy, which uses as emitter a gallium aluminum arsenide (GaAlAs) laser diode with a maximum continuous emission power of 60 mW or 40 mW depending on the applicator used. It also has a digital control of the parameters to vary between them, the power and the treatment time, showing at all times the energy density corresponding to the chosen values, which allow the proper dosage of the amount of light emitted. in relation to the requirements of the therapy used. These equipments can present several failures that make it impossible to function properly. This led to the completion of this thesis, which aims to develop software capable of operating laser-therapy equipment using PIC microcontrollers. Different bibliographies were used for the development of the work, as well as the PIC C Compiler program for the configuration and programming of the device and the Proteus 8 Professional software to carry out the simulations of the program. As a result of this work, the equipment was reprogrammed and returned to their hospital institutions.
FACTORES DE RIESGOS Y SU INCIDENCIA EN EL CAMPO INDUSTRIAL
Authors: Romero Mieles Bryan J. , Briones Cedeño Roberth J. , Anchundia Loor Andrés M.
Published: July 2022

La importancia de abordar el tema de los factores de riesgos y su incidencia en el campo industria permite obtener mayor un amplio conocimiento de desde la identificación y caracterización de las principales síntomas, tópico que se presenta durante todo el presente extenso, además mediante la metodología aplicada que estuvo basada en la revisión y comparación de documentos sobre el tema de factores de riesgo se pudo determinar algunas medidas de prevención y formas de evaluación que se deben considerar para evitar estos factores que perjudican directamente al ser humano y a otros elementos de ambiente.

Palabras claves: Factores de riesgo, prevención, elementos ambientales.
Implementation and Design of Fuzzy Supervisory Controller for Mobile Robot Manipulator
Authors: Ali Ramzy , Aldair Ammar , Almousawi Ali
Published: July 2022

The Mobile Manipulator Robot (MMR) has manyapplications in different aspects of the life, for example,grasping and transporting, mining, military, manufacturing,construction, and others. The benefits of MMR rise in a dangerous place where the human cannot reach such asdisaster areas and dangerous projects sites. In this work, thePID controller is combined with Fuzzy Logic Controller (FLC)to structure the Fuzzy Supervisory Controller (FSC) toovercome the drawbacks of PID controller and to obtain theadvantages of FLC. Two approaches are suggested for thenavigation of Autonomous Mobile Robot (AMR). These are;goal reaching fuzzy control (GRFC) and the obstacle avoidancefuzzy control (OAFC). The hardware implementation of theAMR is performed using AVR ATmega32 microcontroller, twoDC motors, light dependent resistor (LDR) and five Infra Redsensors. While the Laboratory robot arm with somefabrications is used as manipulator's arm with a five degrees-of-freedom. Then a microcontroller is employed to implement theproposed controller for MMR. The designed MMR is tested inreal environments and give a good navigation.
Hybrid approach for multi-node localization and Identification
Authors: Hasan Ola , Rashid Abdulmuttalib , Ali Ramzy
Published: July 2022

In this paper, a new approach for the positioning(localization) of multi-node systems is presented. Each nodeincluding the beacon node contains two types of sensors: onefor the distance sensing and the other type is forcommunication. The main idea of our proposed approach is touse the control of beacon to construct anodes' tree which isgoing to be used later by the nodes to know the paths in whichthe information will flow. During the tree construction, theidentities of nodes will be known. Every node except thebeacon will use the information obtained from its previousneighbor in the tree to find its own location and orientation.Several simulations using visual basic 2012 are implemented todiscern the performance of this algorithm.
Leader Follower Tracking with Obstacle Avoidance using Circular Paths Algorithm
Authors: Rashid Abdulmuttalib
Published: July 2022

This paper deals with a new algorithm called circularpaths for leader follower tracking with obstacle avoidanceusing. In leader-follower tracking, one robot acts as a leaderwith defined motion and the other robot acts as a follower whichposition itself in accordance with the position and orientation ofthe leader. The leader movement is dependent on an assignedtrajectory and the follower movement is dependent on thecircular paths algorithm. In each step, this algorithm constructsa circular path using three points represented by the next stepposition of the leader robot, the last step position and thecurrent step position of the follower robot. The next position ofthe follower robot lays on the circumstance of the circular pathand the orientation is represented by the tangent line to thiscircular path at this next position of the follower robot. Whenan obstacle intersect any circular path for the follower robot,then this path must be replaced by another circular pathconstruct from the two positions of the follower robot and theleader position is replaced by the tangent point to the obstacle.Simulation results illustrate the soundness of this algorithm.
Prediction-Based Path Planning with Obstacle Avoidance in Dynamic Target Environment
Authors: Ibrahim Zahraa , Rashid Abdulmuttalib , Marhoon Ali
Published: July 2022

In this paper, a new algorithm for mobile robot navigation and polygonal obstacles avoidance in dynamic target environment is introduced. In the dynamic target path planning theagent (robot) trying to reach a moving target in minimum pathcost. The introduced algorithm which called Prediction-basedpath planning with obstacle avoidance in dynamic target environment planning a path to a moving target by predicting the nexttarget location, then computing a path from the robot current location to the predicted target location representing each visibleobstacle by the smallest circle that enclosing the polygon obstacle,then determine the visible tangents between the robot and the circular obstacle that intersect its shortest path and compute theshortest path. Three target movement scenarios were suggestedand tested in different environment conditions. The results showthat the target was reached in all scenarios and under all environment conditions with good path cost.
Kesiapan Belajar Online Mahasiswa Profesi Keperawatan di Masa Pandemi COVID-19
Authors: Tirta Suminar Istinengtiyas , Anisa Diah Nur
Published: July 2022

Penggunaan tehnologi dalam pembelajaran daring merupakan alternatif pembelajaran di masa pandemi. Pengukuran terhadap kesiapan mahasiswa dalam menjalankan pembelajaran daring perlu dilakukan demi keberhasilan dan kepuasan penerapan pembelajaran daring. Tujuan penelitian ini untuk mengetahui kesiapan mahasiswa profesi Ners dalam pembelajaran daring Covid-19. Penelitian ini merupakan penelitian deskriptif kuantitatif menggunakan pendekatan survei. Sampel dalam penelitian ini adalah 41 mahasiswa Profesi Ners Program Studi Profesi Ners Universitas ‘Aisyiyah Yogyakarta TA 2020/2021. Tehnik pengambilan sampel menggunakan purposive sampling dan penelitian ini dilakukan pada bulan Juni-Juli 2021. Instrumen yang digunakan dalam penelitian adalah Student Online Learning Readiness (SOLR) untuk mengukur kesiapan mahasiswa dalam pembelajaran daring. Analisis data yang digunakan menggunakan analisis Univariate. Hasil penelitian menunjukkan bahwa sebagian besar mahasiswa memiliki tingkat kesiapan yang tinggi dalam pembelajaran online (63,4%). Kesimpulan dari penelitian ini adalah kesiapan siswa yang tinggi dalam melaksanakan pembelajaran online diperlukan untuk mencapai keberhasilan pelaksanaan pembelajaran online.

The use of technology in online learning is an alternative to learning during a pandemic. Measurement of student readiness in carrying out online learning needs to be done for the success and satisfaction of implementing online learning. The purpose of this study was to determine the readiness of nursing professional students in online learning for Covid-19. This study was a quantitative descriptive study using a survey approach. The sample of study was 41 students of the Nursing Profession Program of the Nursing Profession Program at the University of Aisyiyah Yogyakarta 2020/2021. The sampling technique used purposive sampling and the study was conducted in June-July 2021. The instrument used in the study was Student Online Learning Readiness (SOLR) to measure student readiness in online learning. Analysis of the data used Univariate analysis. The results showed that most of the students had a high level of readiness in online learning (63.4%). The conclusion of the study is that high student readiness in carrying out online learning is needed to achieve the successful implementation of online learning.
KONGRUENSI PEMBELAJARAN SKILL LAB KEPERAWATAN DENGAN FACULTY LEARNING OUTCOME TENTANG PROSES ASUHAN KEPERAWATAN
Authors: Hasnah Kholifah , Setyaningsih Rahayu
Published: July 2022

Proses asuhan keperawatan terdiri dari pengkajian data, diagnosa keperawatan, intervensi keperawatan, implementasi keperawatan dan evaluasi tindakan keperawatan. Asuhan keperawatan diajarkan mahasiswa untuk mempersiapkan sebelum praktek dirumahsakit, sehingga perlu diberikan pada skill lab keperawatan. Tujuan dari penelitian ini adalah mengetahui kesesuaian pembelajaran skill lab keperawatan dengan faculty learning outcome tentang asuhan keperawatan. Penelitian ini menggunakan metode kualitatif dengan content analisys. Penelitian ini menganalisis konten checklist penilaian resume keperawatan dan faculty learning outcome tentang proses asuhan keperawatan. Jumlah checklist penilaian resume askep keperawatan adalah 20. Penelitian ini menggunakan 2 koder yang nantinya akan menganalisis dari keseluruhan dokumen penelitian Hasil penelitian didapatkan prosentase konten asuhan keperawatan yang sesuai dengan faculty learning outcome adalah 62% dan terdapat extended learning outcome sebesar 38% pada pembelajaran skill lab keperawatan. Kesimpulan model kongruensi antara pembelajaran skill lab keperawatan dengan faculty learning outcome yaitu sebagian besar faculty learning outcome sudah dirumuskan pada pembelajaran skill lab keperawatan sebesar 62 % tentang proses asuhan keperawatan. Saran perlu  adanya penelitian selanjutnya yang berkaitan dengan extended learning outcome pada pembelajaran teori keperawatan.

               The nursing care process consists of data assessment, nursing diagnoses, nursing interventions, nursing implementation and evaluation of nursing actions. Nursing care is taught by students to prepare before practicing in the hospital, so it needs to be given to nursing lab skills. The purpose of this study was to determine the suitability of nursing lab skills learning with faculty learning outcomes about nursing care. This study uses a qualitative method with content analysis. This study analyzes the content of the nursing resume assessment checklist and faculty learning outcomes about the nursing care process. The number of checklists for assessing the nursing ascetics resume is 20. This study uses 2 coders which will later analyze the entire research documentThe results showed that the percentage of nursing care content that was in accordance with faculty learning outcomes was 76% ​​and there were extended learning outcomes in nursing lab skills learning. The conclusion of the congruence model between nursing lab skills learning and faculty learning outcomes is that most of the faculty learning outcomes have been formulated in nursing skills learning about 62% the nursing care process. Suggestions need for further research related to extended learning outcomes in nursing theory learning.
Análisis de los linajes paternos en la ciudad de Trujillo, Perú
Authors: Sala Camila , Paz Sepulveda Paula Beatriz , Cuello Mariela , Schwab Marisol , Jurado Medina Laura Smeldy , Motti Josefina María Brenda , Santos María Rita , Aquilano Eliana , Martín Alva Enrique A. , Mejia Porturas Martha , León Torres Carlos Alberto , Alfaro Gómez Emma Laura , Dipierri José Edgardo , Demarchi Darío A. , Muzzio Marina , Bravi Claudio Marcelo , Bailliet Graciela
Published: July 2022

El actual territorio de Trujillo, una ciudad costera en el Norte de Perú, fue ocupado por diversas culturas precolombinas a lo largo de la historia. Con la llegada de los conquistadores europeos en el siglo XVI, se inició un proceso de mestizaje que continúa hasta la actualidad. Los objetivos de este trabajo son identificar y caracterizar linajes autóctonos y alóctonos del cromosoma Y en la población de Trujillo y evidenciar fenómenos del poblamiento y similitudes entre la población en estudio y poblaciones de Argentina. Se analizaron los linajes paternos a través de la región no recombinante del cromosoma Y por medio de un método de amplificación alelo-específica para la identificación marcadores bialélicos (SNPs) que determinan haplogrupos autóctonos y alóctonos para América en reacciones PCR-AFLP multiplex. Tal como se esperaba, esta población presentó una ancestralidad predominantemente nativa, con una alta influencia de linajes europeos.
A gestão dos ilegalismos enquanto mercado
Authors: De Pieri Pimentel André , Isabela Vianna Pinho
Published: July 2022

Em São Paulo, como em outras cidades na América Latina, o crime e os ilegalismos são temáticas muito debatidas publicamente. Enquanto alguns acusam o estado e a polícia pelo uso da violência e da letalidade como mecanismos de combate ao crime, outros defendem uma narrativa de “guerra ao crime”, que sustenta e justifica tais mecanismos. Esse artigo parte de pesquisa multimétodos sobre o roubo e o furto de veículos em São Paulo, buscando analisar interfaces entre o campo da Segurança Pública e a produção de mercados e desigualdades. Mais do que um campo político, a Segurança é também um campo gestionário e econômico, composto por agentes estatais, segmentos da sociedade civil e o capital privado. Ao mesmo tempo que a gestão desses ilegalismos produz desigualdade e violência, especialmente entre os mais pobres, há quem ganhe muito dinheiro produzindo e explorando fronteiras entre o legal e o ilegal.
Types of Food of Tamils and the Hospitality attribute of the King
Authors: A Vimalarani
Published: July 2022

Food, clothing, and shelter are the basic resources of human life. Food is the primary resource not only for human life but for all life that has appeared in this world. Tamils prepared and ate a wide variety of foods, both produced by specialised cultivators and uncultivated. The Sangam people were very fond of eating vegetarian food and meat. They also ate many kinds of alcoholic dishes. Our Tamils, who lived on food as medicine, lived on the basis of five land divisions, namely Kurinji, Mullai, Marutham, Neithal, and Paalai. People living in their respective places used to enjoy cooked and uncooked food from the land. This article is intended to examine how the people of the five land classes based on the division of Tamil Nadu ate the food items available near their residences, not only grass but also meat food and types of wine, and the king's hospitality attribute.
Personification of Puranaanutru Avvai
Authors: D Ammu
Published: July 2022

Personality is the ability to govern oneself and others. In psychological terms, personality refers to a person's organised dialectical characteristics and the resulting attitudes, behaviors, feelings, and thoughts. Personality in general refers largely to one's outward appearance. Although women were not given full freedom during the Sangam period, they excelled in many fields during that time. As well as excelling in various fields, they were well versed in Tamil as well. Reminiscing about the excellence of Sangam period woman poet Avvaiyaar and studying her language skills and intellect can teach us a lot. Sangam women lived a life of virtue, chivalry, love, pleasure and nature. Because they were literate, they became creators and recorded the lives of women. Women were the root of the akappaatalkal (poetry of love genre). Most of the epithets built on femininity are seen in Akappaatalkal as Thalaivi (woman-lead), Thozhi (friend), Virali (young girl), Natraai (mother), Sevilitthai (nanny). Literature is the one that captures various aspects of life. In it, the speech and life of Purananutru Avvaiyaar are seen with pride. Though Athiyaman Neduman Anci was a king of a small region, she befriended him and stayed in his court till the end. She sang heroic songs, especially for the king. She tirelessly supported Anji till the end. She had lived a simple life and was considered a worldly poet because of her respect for humanity and culture. The new saying is that good things happen and evil things are destroyed by women. Women are gifted with wisdom and intelligence. The qualities of excellence, knowledge, humility, etc. are inherent in nature. The purpose of this article is to look only at the personality of Puranaanutru Avvaiyaar.