bluuebunny/crossref_metadata_2025 huggingface dataset:
Differential expression of BRF1 in amyotrophic lateral sclerosis.
Authors: Mamoor Shahan
Published: December 2022

Neurodegenerative diseases that affect the motor neurons, including amyotrophic lateral sclerosis (ALS), have little treatment options and are generally rapidly fatal (1, 2). We harnessed the power of unbiased, whole transcriptome differential gene expression analysis, utilizing primary patient cells and tissues to discover genes whose expression defines ALS using published data (3, 4). We found significant differential expression of BRF1, encoding BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit, in iPSC-derived motor neurons of patients with ALS. BRF1 was also differentially expressed in primary lower motor neurons isolated from patients with ALS. BRF1 transcript was present at significantly lower levels in ALS iPSC-derived motor neurons. These analyses will begin to define the transcriptional landscape of ALS.
FUNGSI ADMINISTRASI PENDIDIKAN
Authors: AZIZAH VIKI NUR
Published: December 2022

Catatan terkait dengan pengertian fungsi adminitrasi pendidikan dan macam-macam fungsi adminitrasi pendidikan
Resume klp 7
Authors: febianil
Published: December 2022

Kebijakan diartikan sebagai peraturan dan tindakan yang diambil oleh para pemimpin untuk berupaya mencapai tujuan yang telah ditargetkan.Kebijakan moneter berperan dalam mengendalikan jumlah uang yang beredar menggunakan instrumen moneter tertentu melalui transmisi moneter dengan tujuan akhir, sebagaimana yang utama adalah pencapaian stabilitas harga.Fokus utama kebijakan moneter dalam Islam yakni pada pemeliharaan perputaran sumber daya ekonomi, dengan hukum-hukum syariah seperti ketiadaan suku bunga dalam ekonomi, sehingga tidak ada lagi alasan bagi para pemegang dana untuk menahan uangnya di pasar keuangan.
WAWANCARA BISNIS
Authors: NOER MUH. AFTA , Arniyati  , farida Puspa
Published: December 2022

Persaingan di era global seperti sekarang ini sangatlah ketat, bayangkan saja setiap tahunya semua perguruan tinggi meluluskan ribuan mahasiswa yang dia anggap sudah lulus dan mempunyai kesempatan untuk terjun di dunia kerja. Banyak dari mereka yang memilih membuat usaha sendiri meskipun dengan lingkup yang masih kecil. Akan tetapi tidak sedikit pula yang masih menginginkan menjadi seorang karyawan di sebuah perusahaan ternama. Bagi para calon karyawan yang sedang melamar suatu pekerjaan, ada beberapa hal yang penting untuk di persiapkan salah satunya adalah tahap wawancara kerja. Dalam menghadapi wawancara kerja membutuhkan persiapan fisik dan mental, terutama bagi generasi muda yang minim pengalaman.
Category and Depth Discrimination in Real-World Scenes
Authors: Anderson Matt D
Published: December 2022

Visual understanding of real-world scenes is near-instantaneous. Humans can extracta wealth of information, including spatial structure, semantic category, and theidentity of embedded objects, from images viewed for fewer than 100 msecs. Visualprocessing has capacity limits, and, as a result, the computational processes thatunderlie this behaviour must be highly efficient. Computational theories of realworldscene perception model early image processing in various ways. In Chapter 1,I review these theories, and in Chapter 2, I review the role of depth cues in rapidvisual processing. This discussion reveals three problems: (i) Tests of the agreementbetween model predictions and human responses may be biased by the arbitrarychoice of category system, (ii) Current models posit that scene semantics isestimated from spatial structure properties, but empirical support for this position isinconsistent, and (iii) The time-course of depth estimation in real-world scenes ispoorly understood. To address these problems, three empirical papers are presentedin Chapters 3, 4, and 5. In Chapter 3, I propose and validate a novel clusteringalgorithm that can be applied to image databases to derive category systems forvisual experiments. In Chapters 3 and 4, I examine the relationship between spatialstructure and semantic information, and find little support for the position that spatialstructure properties inform semantic discrimination. In Chapters 4 and 5, Icharacterize the time-course of depth processing for images presented for <267msecs, and conclude that binocular disparity and elevation cues contribute to realworldperception shortly after image onset (<50 msecs). These findings are discussedtogether in Chapter 6. This thesis contributes to the evaluation of modern models ofreal-world scene perception, and helps to characterize how visual understandingunfolds over time.
Differential expression of MMP1 in amyotrophic lateral sclerosis.
Authors: Mamoor Shahan
Published: December 2022

Neurodegenerative diseases that affect the motor neurons, including amyotrophic lateral sclerosis (ALS), have little treatment options and are generally rapidly fatal (1, 2). We harnessed the power of unbiased, whole transcriptome differential gene expression analysis, utilizing primary patient cells and tissues to discover genes whose expression defines ALS using published and public data (3, 4). We found significant differential expression of MMP1, encoding matrix metalloproteinase 1, in induced pluripotent stem cell (iPSC)-derived motor neurons from patients with ALS. Analysis of a second public microarray dataset demonstrated that MMP1 differential expression in iPSC-derived motor neurons was a conserved feature in humans with ALS. MMP1 transcript was present at significantly higher levels in ALS patient motor neurons as compared to control motor neurons. These analyses will begin to define the transcriptional landscape of ALS.
Differential expression of ANKRD28 in amyotrophic lateral sclerosis.
Authors: Mamoor Shahan
Published: December 2022

Neurodegenerative diseases that affect the motor neurons, including amyotrophic lateral sclerosis (ALS), have little treatment options and are generally rapidly fatal (1, 2). We harnessed the power of unbiased, whole transcriptome differential gene expression analysis, utilizing primary patient cells and tissues to discover genes whose expression defines ALS using published data (3, 4). We found significant differential expression of ANKRD28, encoding ankyrin repeat domain 28, in induced pluripotent stem cell (iPSC)-derived motor neurons of patients with ALS. ANKRD28 was also differentially expressed in fibroblasts isolated from patients with ALS. ANKRD28 transcript was present at significantly lower levels in ALS iPSC-derived motor neurons. These analyses will begin to define the transcriptional landscape of ALS.
Sistem Stabilitas Keuangan (SSK) dan Stabilitas Moneter
Authors: Halim Ismail
Published: December 2022

Resume singkat terkait sistem Stabilitas Keuangan dan stabilitas moneter di Indonesia.
A Web-based Analytical Urban Flood Damage and Loss Estimation Framework
Authors: Alabbad Yazeed , Yildirim Enes , Demir Ibrahim
Published: December 2022

Information and communication technology serves a crucial role in communicating flood risk and consequences to a broad range of stakeholders and facilitating mitigation decisions. While studies extensively utilize flood inundation maps for communicating flood risks, there is a need to integrate a broad spectrum of physical vulnerability parameters into risk estimates at various spatial scales. This research aims to build a publicly accessible web platform to analyze and estimate riverine flood-related damages using HAZUS and HEC-FIA damage functions at community and property spatial scales. This framework will provide loss estimation for properties, business interruption, vehicles, bridges, and lives, as well as debris generation. The analysis is available for two scopes, including community and property. The community extent enables the user to explore socioeconomic flood information in the event of 100- and 500-year flood return periods for several communities in the State of Iowa. In the property scope, the user can generate outcomes for the impacts of "what if" flood scenarios using user-provided data. The framework disseminates flood information without requiring extra software to be installed on the user's local workstation. It offers a guidance tool to help decision-makers with flood management, such as identifying vulnerable areas and investigating mitigation interventions.
Global climate change trends detected in indicators of ocean ecology
Authors: Cael B. B. , Bisson Kelsey , Boss Emmanuel , Dutkiewicz Stephanie , Henson Stephanie
Published: December 2022

Climate change-driven trends in phytoplankton populations, as viewed by Earth-observing satellites, were thought to be masked by strong natural variability, so that >30 years of continuous data was needed to detect a climate trend. Here we show that climate change trends emerge more rapidly in ocean color (remote sensing reflectance, Rrs), as Rrs is multivariate and some wavebands have low interannual variability. We find significant trends in a twenty-year time-series of Rrs from the MODIS-Aqua satellite over 52% of the global surface ocean, primarily equatorward of 40º. The climate change signal in Rrs emerges after twenty years in similar regions covering a similar fraction of the ocean in a state-of-the-art ecosystem model, implying that the observed trends may indeed be driven by climate change. Ocean color may thus be a sentinel of climate change in surface ocean ecology and biogeochemistry.
A Formative Evaluation of Tribal Casino Threat Assessment and Management Practices
Authors: Blake Ashley , Bolante Rebecca , Hopper Sarah , Pratt Cori , Bennett James
Published: December 2022

The tribal gaming industry has flourished and continues to grow rapidly, with American Indian gaming revenues surpassing the traditional Las Vegas Strip for gambling. As this industry continues to succeed and tribal self-sufficiency is encouraged, the need for safety and security protocols are essential for both the industry's growth and the community's peace of mind. Casino concerns around violence can range from domestic violence, active shooter, fire, explosion, chemical exposure, cyber threats, and IT vulnerabilities.
Disequilibrium as Determinant of Reinforcement and Punishment Effects: A Replication
Authors: Jacobs Kenneth W. , King James , Dowdy Art
Published: December 2022

Response disequilibrium theory, an extension of the response deprivation hypothesis, proposes that behavior-change is due to disruptions in an organism's baseline levels of responding. This theory challenges the notion of distinct stimuli as reinforcers or punishers and instead emphasizes the role of instrumental and contingent activities. The present study aimed to test the predictions of response disequilibrium theory by replicating Heth and Warren's (1978) experiment using a modernized apparatus. Sixteen undergraduate psychology students participated in the experiment, which included a familiarization period, baseline periods, and a contingency period. During the contingency period, the instrumental activity was the activation of a video that resulted in a deficit or excess of audio relative to baseline. According to response disequilibrium theory, a deficit will produce a reinforcement effect while an excess will produce a punishment effect. The results supported the predictions of response disequilibrium theory, as instrumental video activity increased for participants in the deficit condition and decreased for participants in the excess condition. Additionally, the study revealed a strong correlation between the size of disequilibrium and the magnitude of behavior change. These findings further support the use of disequilibrium models to a priori identify effective contingency arrangements in both research and practice. Informal applications of the Premack principle may be supplanted with the precision of a formal model of reinforcement and punishment in response disequilibrium theory.
‘Episodic Conditioning’: a novel approach to study the intersection of Pavlovian threat conditioning and episodic memory.
Authors: de Vries Olivier , Duken Sascha Béla , Dzinalija Nadza , Kindt Merel , van Ast Vanessa Anna
Published: December 2022

The powerful ways future behavior and cognition can be affected by emotional events are typically studied either by means of Pavlovian conditioning or episodic memory paradigms. However, due to their incompatible methods, little is known about how Pavlovian conditioning and episodic memory relate to each other, or work in concert to affect behavior and other cognitive processes. Here, we present a novel stimulus set consisting of 60 negative, neutral, and positive image/sound combinations (Affective Multi-modal Stimuli; AMS) that elicited strong subjective and psychophysiological emotional responses, the latter of which transferred to arbitrary predictors already after a single paired presentation in a new paradigm (Episodic Conditioning). Real-life emotional events are likely to involve both Pavlovian conditioning and episodic memory processes. The episodic conditioning paradigm enables their simultaneous assessment, thereby providing an opportunity to gain more holistic insight into how these process interact in sickness and in health.
How Incidental and Intentional News Exposure in Social Media Relate to Political Knowledge and Voting Intentions
Authors: Dreston Jana H , Neubaum German
Published: December 2022

Citizens are expected to make informed voting decisions. However, research suggests that political knowledge gained through media use is not related to political participation such as voting. In times of declining voter turnout and increasing news consumption via social media, we analyzed how the two relate. Recent research highlighted that social media rather than increasing objective knowledge, mostly fosters the metacognition of subjective knowledge. This metacognition, in turn, promotes political participation. Nevertheless, it is yet to be examined which forms of social media use foster users’ perceptions of being political knowledgeable and whether the subjective knowledge-participation link can be extended to voting. Results from a pre-election survey among social media users showedthat intentional, but not incidental news exposure is related to increased objective and subjective knowledge. Political talk is crucial in explaining the associations of both incidental news exposure and intentional news search with knowledge. The association between social media news use and voting intention can be explained by subjective knowledge. By showing that incidental and intentional social media use affect knowledge differently, this studyprovides preliminary and nuanced insights into the ultimate role these technologies can play in democratic processes.
Symptom networks in glioma patients: understanding the multidimensionality of symptoms and quality of life
Authors: Röttgering Jantine Geertruida , Varkevisser T.M.C.K. , Gorter Maxine , Belgers Vera , De Witt Hamer Philip C. , Reijneveld Jaap , Klein Martin , Blanken Tessa , Douw Linda
Published: December 2022

Purpose: To comprehend the complex relationship between symptoms and health-related quality of life (HRQoL) in patients with diffuse glioma, we applied symptom network analysis to identify patterns of associations between depression, cognition, brain tumor-related symptoms, and HRQoL. Additionally, we aimed to compare global strength between symptom networks to understand if symptoms are more or less associated within different subgroups of patients.Methods: We included 256 patients and stratified the sample based on disease status (preoperative vs. postoperative), tumor grade (grade II vs. III/IV), and fatigue status (non-fatigued vs. fatigued). For each subgroup of patients, we constructed a symptom network. In these six networks, each node represented a validated subscale of a questionnaire and an edge represented a partial correlation between two nodes. We statistically compared global strength between networks.Results: Across the six networks, nodes were highly correlated: fatigue severity, depression, and social functioning in particular. We found no differences in GS between the networks based on disease characteristics. However, global strength was lower in the non-fatigued network compared to the fatigued network (5.51 vs. 7.49, p<0.001).Conclusions: Symptoms and HRQoL are highly interrelated in patients with glioma. Interestingly, nodes in the network of fatigued patients were more tightly connected compared to non-fatigued patients. Implications for Cancer Survivors: We introduce symptom networks as a method to understand the multidimensionality of symptoms in glioma. We find a clear association between multiple symptoms and HRQoL, which underlines the need for integrative symptom management targeting fatigue in particular.
The Curious Case of the Jury-Shaped Hole: A Plea for Real Jury Research
Authors: Ross Lewis
Published: December 2022

**Forthcoming in The International Journal of Evidence & Proof** Criminal juries make decisions of great importance. A key criticism of juries is that they are unreliable in a multitude of ways, from exhibiting racial or gendered biases, to misunderstanding their role, to engaging in impropriety such as internet research. Recently, some have even claimed that the use of juries creates injustice on a large-scale, as a cause of low conviction rates for sexual criminality. Unfortunately, empirical research into jury deliberation is undermined by the fact that researchers are unable to study live juries. The indirect sources of evidence used by researchers suffer from various problems, the most important of which is dubious levels of ecological validity. Real jury research—studying live jury deliberation—is controversial. However, as I argue, the objections to it are unconvincing. There is in fact a moral imperative to facilitate real jury research.
Schmidt et al_2022_PrePrint Welcome How are you doing
Authors: Schmidt Telja
Published: December 2022

A PEER-REVIEWED VERSION OF THIS ARTICLE HAS BEEN PUBLISHED IN THE EUROPEAN JOURNAL OF PSYCHOTRAUMATOLOGY (TAYLOR & FRANCIS): https://www.tandfonline.com/doi/full/10.1080/20008066.2023.2202053 Background: Compared to the general German population, refugees in Germany are a high-risk group for trauma spectrum disorders. Currently, many barriers exist for the implementation of a screen-and-treat approach for mental disorders as part of the routine health care provision during the early stage of the immigration process. Objective: The aim of the present study was to develop and test a systematic screening approach to identify individual refugees in need of mental health care during the initial immigration phase. Method: 167 newly arrived refugees underwent a screening interview with the Refugee Health Screener (RHS) carried out by Intercultural Therapy Assistants (ITAs). The ITAs were supervised by psychologists at a reception center in Bielefeld, Germany. A subsample of 48 persons participated in clinical validation interviews. Results: Findings demonstrated the need for and feasibility of a systematic screening during the initial immigration phase. However, established cut-off values of the RHS had to be adapted and the screening procedure had to be adjusted due to the needs of a significant number of refugees in severe psychological crises. Conclusion: A systematic screening that is applied shortly after arrival facilitates the early identification of refugees at risk of developing mental disorders and may be helpful to protect them from harmful consequences of their symptoms.
Some Effects of Mantramic Chanting in a Therapeutic Growth Process
Authors: Bechek Mandara
Published: December 2022

This experimental project attempted to investigate mantramic chanting as a aid to a therapeutic growth process. The mantra studied was Om Namah Shivaya and the process investigated was Mukti. Mukti's goals are to attempt to provide in a 3-month period a gut-level, comprehensive education and counseling program, which can help sincere individuals, committed to working through their negativities, to free themselves form the adopted habits and attitudes of parental programming. The ultimate goal of Multi is to experience the Self. The problem is to verify whether mantric chanting significantly facilitated higher states of consciousness, while simultaneously decreasing anxiety and other stress related problems. The actual results from this study seem to suggest that chanting Om Namah Shivaya was an effective therapeutic aid for Mukti students. This study tends to support the findings of other researchers, who discovered that mantramic chanting could be effective in a therapeutic growth process as an aid to personal growth.
СОЦИАЛЬНО-КОММУНИКАТИВНАЯ СРЕДА АНГЛОФОННОГО СООБЩЕСТВА В ОТРАЖЕНИИ СОВРЕМЕННОГО АНГЛИЙСКОГО ЯЗЫКА
Authors: Kulikova O.V.
Published: December 2022

The article is devoted to the changes occurring in the social and communicative environment of the modern English-speaking community that are caused by the phenomena of the extralinguistic plan and are verbalized through neologisms of the English language. As a research material, the new vocabulary is used, which is gradually entering the English-language discourse and is not currently recorded in the English monolingual explanatory or encyclopedic dictionaries. The cases of the emergence of new vocabulary in the zone of integration of social and communicative spheres are investigated. Sociopragmatic factors of the English language development are revealed. The socio-communicative spheres serving as «donors» of the modern English language are determined.
ЯЗЫК ПРАВА В СВЕТЕ РАЗЛИЧИЯ ЛИНГВОКУЛЬТУР
Authors: Oparina E.O.
Published: December 2022

В обзоре исследуется проблематика межъязыковой и межкультурной коммуникации в правовой сфере. В центре внимания - вопросы перевода, среди трудностей которого - не только языковая специфика терминологических единиц, но также особенности юридических концептосфер, вызванные различиями культурных и коммуникативных стереотипов, характерных для носителей языков. В обзоре показано, что подобные различия касаются не только далеких друг от друга языков и культур, но даже одного языка, функционирующего в странах с близким социально-политическим устройством.
“Compound Dispossession” in Southern Ontario: Converging Trajectories of Colonial Dispossession and Inter-Indigenous Conflict, 1886–1900
Authors: Reid Darren
Published: December 2022

Throughout the 1880s and 1890s, two First Nations groups—the Chippewa of the Thames and the Six Nations of the Grand River—attempted to evict two other First Nations groups—the Munsee of the Thames and the Mississauga of the Credit—from the Thames and Grand River reserves in southern Ontario. These land disputes were successfully resolved by the turn of the twentieth century and no evictions did take place, but the 20 years of conflict are revealing of the complexities, contingencies, and evolutions of dispossession in Canada over the nineteenth century. This article presents a narrative of these attempted evictions and proposes the concept of “compound dispossession” as a means of grappling with these complexities. It is argued that compound dispossession not only captures the snowballing complications of historical dispossessions over time, but also captures the imbrication of multiple disparate trajectories of dispossession as the pressures of settler land hunger and encroachments on Indigenous sovereignty in the late nineteenth century bore down on four neighbouring First Nations groups simultaneously. Rather than interpreting these conflicts through a binary of assimilation/resistance, compound dispossession suggests the pervasiveness of dispossession as a discourse and the agency of dispossession as an adaptation to the unfolding settler-colonial paradigm.
Políticas Indutoras de Educação Integral: uma revisão sistematizada
Authors: Sena Almeida Ediane , Imbiriba Sousa Colares Maria Lília
Published: December 2022

Este artigo tem por objetivo apresentar o estudo da produção do conhecimento sobre a temática das políticas indutoras de educação integral publicada nos periódicos vinculados ao Fórum de Editores da área de Educação Norte Nordeste/FEPAE-NNE, no período de 2017 a 2020. Utilizou-se a metodologia do tipo revisão sistemática, de caráter bibliográfico, com uma abordagem qualitativa. Os dados foram coletados nos sites dos periódicos supracitados. Foram identificados 49 periódicos vinculados ao FEPAE-NNE, dos quais sete foram incluídos pelo critério indexadores. Através da busca feita por palavras-chave, foram localizados 608 artigos. Após análise, dois periódicos foram excluídos. De forma que a análise final transcorreu sobre 30 artigos, distribuídos em 5 periódicos. Os resultados demonstram que houve uma queda das publicações sobre o tema no ano de 2020, 23 relatos de problemas para a implementação de políticas indutoras de educação integral referentes a organização escolar e uma lacuna, pois, das 30 pesquisas investigadas, apenas um artigo investigou o Programa Novo Mais Educação.
Educação Integral como concepção educacional: análise a partir dos Cadernos Pedagógicos do Programa Mais Educação
Authors: Magalhães Nadja Regina Sousa , Dias Cláudia Maria Costa , Brandt Andressa Graziele
Published: December 2022

Este artigo, que surge em discussões tecidas na investigação no Doutorado em Educação do Programa de Pós-Graduação em Educação na Universidade Federal de Pelotas, no grupo de estudos acerca de Educação Integral, tem como objetivo analisar as concepções de educação integral instituídas através dos Cadernos Pedagógicos do Programa Mais Educação. Optou-se por uma pesquisa de caráter qualitativa dos dados, através da análise bibliográfica. Com o aporte teórico e metodológico, analisamos os descritores: educação integral, processos sociais, tempo e saberes. Os resultados revelaram que o Programa Mais Educação de educação integral, a partir dos cadernos, em dado momento histórico e político, sofreu modificações com as reformas que afetaram a continuidade epistemológica que contêm esses manuais. Para tanto, as políticas públicas de educação integral para jornada escolar no contexto atual, não foram priorizadas, mesmo sendo estabelecidas nas leis como: LDB (1996), PNE (2001, 2014). A educação integral como concepção pedagógica analisa a formação dos sujeitos de direitos, em uma perspectiva de dialogicidade com a prática que reafirma a necessidade de aprofundar estudos na área, assim contribuindo no contexto educativo.
Associação entre dermatite atópica e mastocitoma em cães
Authors: Kalil Rebeka Ferro Tosta , Farias Priscila Camargo Granadeiro
Published: December 2022

Foi realizado um estudo para verificar se há associação entre a ocorrência de mastocitoma cutâneo e dermatite atópica em cães atendidos de 2014 à 2018, com a casuística do Hospital Veterinário da Universidade Vila Velha. Foram avaliados os sinais clínicos e exames de pacientes atendidos com diagnóstico de mastocitoma e, com base nos critérios de Favrot, que foram criados com base nas características clínicas do paciente com dermatite atópica canina para facilitar o diagnóstico pelo médico veterinário dermatologista. Dos 26 cães com mastocitoma, 15 (58%) também eram atópicos, (sendo nove (60%) fêmeas castradas e seis (40%) machos castrados). Dos demais, ou seja, 11 animais (42%), seis (55%) eram fêmeas e cinco (45%) machos. Observou-se então nesta pesquisa que os animais atópicos foram os que mais frequentemente apresentaram mastocitoma, sugerindo uma associação entre as duas doenças. Os achados obtidos neste trabalho reforçam a associação entre elas, pois a maioria dos animais com mastocitoma cutâneo também apresentava dermatite atópica canina (n=15), pois atendiam a cinco ou mais critérios de Favrot, ao contrário do grupo controle, com outras quatro neoplasias epiteliais (carcinoma de células escamosas, carcinoma de células basais, tricoblastoma e tricoepitelioma) os quais nenhum animal (n=16) apresentou dermatite atópica canina associada.
Ressecção de adenocarcinoma retal por osteotomia púbica e isquiática em cão: Relato de caso
Authors: Bonatto Giovanna Lapkoski , Kano Natalia Noreika , Barbosa Carolina Konkel , Prieto Wiliam da Silva , Laube Leticia Fernanda , Piontkovsky Robson Junior , Sousa Renato Silva de , Firmo Bruna Fernanda , Carareto Roberta
Published: December 2022

As neoplasias que acometem intestinos de cães são de baixa ocorrência e representam menos de 10% de todas as neoplasias malignas na espécie. Os sinais observados podem incluir tenesmo, diarreia, disquesia, hematoquezia, prolapso anal, anorexia e perda de peso. O prognóstico é bom quando as lesões são localizadas e sua ressecção é completa, mas metástases podem ser observadas em casos mais avançados. O presente relato tem como objetivo expor o caso de um adenocarcinoma retal em um cão, que foi removido através do acesso de osteotomia púbica e isquiática bilateral. A cadela da raça West England Terrier, de nove anos de idade, foi atendida com queixa de sangramento anal, diarreia e hematoquezia há cinco meses. Ultrassom abdominal indicou extensa neoformação intraluminal em porção distal de cólon descendente, com espessamento e perda de estratificação parietal. Colonoscopia caracterizou a massa hemorrágica em reto, com cerca de cinco centímetros de comprimento. Exame histopatológico de fragmentos da massa diagnosticou carcinoma retal. Realizada tomografia computadorizada de abdome e pelve, que também identificou a neoformação intraluminal em reto, sem sinais de obstrução. Não havia sinais de metástase pulmonar ao exame radiográfico e outros exames de triagem não possuíam alterações. Optou-se então pela ressecção cirúrgica da massa, sendo necessária extensão da celiotomia mediana para osteotomia púbica e isquiática bilateral, garantindo o acesso às porções de cólon e reto acometidas, que foram totalmente removidas por enterotomia. A avaliação histopatológica final confirmou o diagnóstico de adenocarcinoma intestinal. A técnica descrita possibilita exposição satisfatória da cavidade pélvica, assim como maior segurança no acesso às suas estruturas. No caso em questão, o planejamento e a técnica cirúrgica adequada permitiram ressecção completa da neoplasia, proporcionando à paciente qualidade de vida a longo prazo.
ASSESSMENT OF MODEL GRASS PLOTS OF THE CITY OF KYIV IN ECO-CONDITIONS OF ANTHROPOGENIC LOAD
Authors: STRASHOK О. , KOLESNICHENKO O. , KALBARCZYK R. , ZIEMIANSKA M. , BIDOLAKH D. , STRASHOK V.
Published: December 2022

Urban heat islands (UHI) and rapid urbanisation create new health risks for residents of urban territories. The authors consider lawns as an eco-stabilising factor of the urban environment and an element of ensuring the environmental safety of the capital. The purpose of this study was to determine the qualitative state of lawns to the factors of the urban ecosystem and their thermoregulatory function. To determine the impact of anthropogenic factors on research objects, the study assessed the amount of emissions into the atmospheric air from stationary and mobile sources, satellite maps of the intensity of nitrogen dioxide emissions (NO2 ) and sulphur dioxide (SO2 ) in the city’s air basin, heat distribution, and normalised difference moisture index (NDMI). To assess the condition and quality of lawns, the methods of assessing the grasslands of A.A. Laptev (1983) and an unmanned aerial vehicle (UAV) were used. It was established that the results of the evaluation of lawn coenoses using the method of O.O. Laptev and UAV are correlated (r=0.87). Lawn areas that were rated as in “satisfactory condition” are characterised by a higher temperature on the heat map and lower NDMI values. Indicators of lawn cover that were rated as in “good condition” correlate with surface temperature and NDMI. The difference in surface temperatures over the area of the experimental sites reaches 5°C and depends on the objects surrounding the perimeter. It was established that lawn areas adjust the thermal mode of the urban system in the warm period of the year, and reduce the temperature of the asphalt surface by about 0.5°C, and together with flower and woody plants – by about 0.9°C. The study results improve the understanding of the physiological effects of heat stress on lawn areas, which allows developing practical strategies for managing urban green spaces with limited water resources and anthropogenic loads
РЕНЕСАНС ПСИХОДЕЛІЧНОЇ ТЕРАПІЇ ТА ЇЇ ЗНАЧЕННЯ ДЛЯ УКРАЇНИ
Authors: Matrenitsky V. L.
Published: December 2022

Протягом останніх десятиліть фармацевтична промисловість не спромоглась запропонувати для потреб психіатрії нових революційних лікарських засобів, а класичні антидепресанти, присутні нині на ринку, демонструють свою недостатню ефективність. Новим рішенням такої проблеми у медицині обіцяє стати друга "психоделична революція", яка активно розвивається з початку нинішнього століття. Застосування ряду психоделічних речовин, зокрема метилендіоксиметамфетаміну (МДМА), псилоцибіну, диметилтриптаміну (ДМТ), діетиламіду лізергінової кислоти (ЛСД) і кетаміну, розглядається у якості найбільш перспективних методів лікування. Психоделіки мають надзвичайну здатність створювати швидкі та тривалі зміни у структурі та функціях нейронів, покращуючи психічний стан пацієнтів навіть після одноразового прийому. Дані ретельно розроблених та контрольовано проведених досліджень свідчать про ефективність застосування цих сполук при депресії, тривозі, посттравматичному стресовому розладі (ПТСР) та залежностях, не викликаючи при цьому фізичної залежності та абстиненції, а частота таких серйозних побічних реакцій, як психотичні епізоди, вкрай низька або взагалі відсутня. Тож нині існує актуальна потреба легалізації психоделічної терапії в Україні.
PACYFIZM JAKO PROBLEM FILOZOFICZNY
Authors: Pawliszyn Mirosław
Published: December 2022

Pacyfizm, na swój sposób dzisiaj zapomniany, to głębokie pytanie o człowieka, to próba uświadomienia, że być może człowiek nie powinien się nigdy na tym właśnie świecie pojawić, chyba że tylko po to, by o miłości marzyć, w nadziei, że wydarzy się ona gdzieś indziej. Jeżeli jednak żyjąc w „dowodliwym” świecie, obserwując fakty, wiemy z niewzruszoną pewnością, że tak nie jest, że krystaliczna miłość jest tylko fantazmatem, po czasie zmienia się bowiem nieustannie w układ przyzwyczajeń, a pokój to tylko niespełniona nadzieja (czego nie trzeba udowadniać), to skąd myśl, że wydarzy się on kiedykolwiek? I tutaj właśnie napotykamy na bodaj najgłębszy problem antropologiczny, twierdzę, że niemożliwy do rozstrzygnięcia, co pokazuje nam filozofia. Niniejsza kwestia będzie analizowana w przedstawionym artykule
WSTĘP DO ANALIZY KRYTYCZNEJ PIŚMIENNICTWA STAROŻYTNEGO SUMERU W KONTEKŚCIE WIEDZY FILOZOFICZNEJ
Authors: Sytnik-Czetwertyński Janusz
Published: December 2022

Artykuł przedstawia krótką analizę krytyczną wybranych pism z czasów cywilizacji sumeryjskiej w kontekście wiedzy filozoficznej. Tekst podzielony jest na dwie części. Pierwsza odnosi się do refleksji sumeryjskiej z zakresu etyki, druga dotyczy wiedzy o świecie zewnętrznym. Bez wątpienia refleksja sumeryjska miała jedynie formułę wiedzy praktycznej, jednak niektóre jej fragmenty wpisują się w kurs przyszłej filozofii.
Fitness Yapan Bireylerin Sosyal Görünüş Kaygısı, Yaşam Tatmini ve Egzersiz Bağımlılığı Düzeylerinin Bazı Değişkenlere Göre İncelenmesi (Ağrı İli Örneği)
Authors: HAZAR Zekihan , ÖZPOLAT Zehra
Published: December 2022

Bu araştırma, fitness yapan bireylerin sosyal görünüş kaygısı, yaşam tatmini ve egzersiz bağımlılığı düzeylerinin çeşitli değişkenlere göre incelenmesi amacıyla yapılmıştır. Çalışma; nicel araştırma modelinde tasarlanmış olup, tarama deseni kullanılmıştır. Araştırmanın evrenini; Ağrı ilinde yer alan fitness merkezleri oluşturmaktadır, örneklemini ise kolayda örnekleme yöntemine göre Ağrı İbrahim Çeçen Üniversitesi Fitness merkezinde spor yapmakta olan 186 katılımcı oluşturmaktadır. Veri toplama araçları olarak; Egzersiz Bağımlılığı Ölçeği, Sosyal Görünüş Kaygısı Ölçeği ve Yaşam Tatmini Ölçekleri kullanılmıştır. Verilerin değerlendirilmesinde SPSS istatistik programından yararlanılmıştır. Elde edilen verilere tanımlayıcı istatistikler yapılmıştır. Elde edilen sonuçlara göre hipotez testleri için parametrik testlerden t- testi uygulanmıştır. Çıkarımsal istatistikler için Pearson Korelasyon analizleri yapılmıştır. Sonuç olarak; katılımcıların egzersiz bağımlılığı ile spor yapma süreleri ve sosyal görünüş kaygıları arasındaki ilişkilerin pozitif yönlü ve istatistiksel olarak anlamlı olduğu görülmüştür. Araştırma kapsamında ele alınan cinsiyet, sporcu lisansına sahip olma ve yaşam tatmini gibi değişkenlere yönelik yapılan analizlerde ise istatistiksel olarak anlamlı bir farklılık ve ilişki tespit edilememiştir.
IMPLEMENTASI MODEL PEMBELAJARAN OPEN ENDED LEARNING UNTUK MENINGKATKAN KEMAMPUAN BERPIKIR KREATIF SISWA KELAS IV SDN SIDOTOTO
Authors: Setiana Savina , Nurhidayati Nurhidayati , Ngazizah Nur
Published: December 2022

Abstrak: Tujuan dari penelitian ini yaitu: (1) Mendeskripsikan langkah-langkah implementasi model Open Ended Learning, (2) Meningkatkan kemampuan berpikir kreatif peserta didik pada materi keliling dan luas bangun datar. Metode penelitian ini adalah Penelitian Tindakan Kelas (PTK). PTK terdiri dari empat tahap yaitu perencanaan, pelaksanaan, pengamatan, dan refleksi. Subjek dari penelitian ini adalah peserta didik kelas IV SDN Sidototo yang berjumlah 14 peserta didik. Teknik pengumpulan data yang digunakan adalah wawancara, tes, dan dokumentasi. Analisis data menggunakan analisis kualitatif dan kuantitatif. Hasil dari penelitian ini yaitu: (1) keterlaksanaan pembelajaran mengalami peningkatan dari siklus I sebesar 82% dengan kategori baik dan pada siklus II menjadi 92% dengan kategori sangat baik. Peningkatan keterlaksanaan pembelajaran dari siklus I ke siklus II adalah 10%, (2) Kemampuan berpikir kreatif peserta didik meningkat. Nilai rata-rata yang diperoleh dalam prasiklus yaitu 53,9. Peningkatan persentase rata-rata pada kemampuan berpikir kreatif peserta didik pada setiap siklus yaitu siklus I 73% dengan kategori cukup dan pada siklus II yaitu mencapai 83% dengan kategori baik. Persentase rata-rata pada indikator kemampuan berpikir kreatif peserta didik pada siklus 2 sudah mencapai indikator keberhasilan yaitu minimal 80%. Berdasarkan hasil penelitian maka model pembelajaran open ended learning dapat dijadikan alternatif untuk meningkatkan kemampuan berpikir kreatif.Abstract:  The objectives of this study are: (1) Describe the steps for implementing the Open Ended Learning model, (2) Improve students' creative thinking skills on the circumference and area of flat shapes. This research method is Classroom Action Research (CAR). CAR consists of four stages, namely planning, implementation, observation, and reflection. The subjects of this study were fourth grade students of SDN Sidototo, totaling 14 students. Data collection techniques used are interviews, tests, and documentation. Data analysis used qualitative and quantitative analysis. The results of this study are: (1) the implementation of learning has increased from the first cycle of 82% in the good category and in the second cycle to 92% in the very good category. The increase in the implementation of learned from cycle I to cycle II is 10%, (2) The creative thinking ability of students increases. The average value obtained in the pre-cycle is 53.9. The average percentage increase in the creative thinking ability of students in each cycle is 73% in the first cycle in the sufficient category and in the second cycle, it reaches 83% in the good category. The average percentage of the indicators of the creative thinking ability of students in cycle 2 has reached the indicator of success, which is at least 80%. Based on the research results, the open-ended learning model can be used as an alternative to improve creative thinking skills.
PENGEMBANGAN MEDIA KONTEKSTUAL PAPAN PETA BUDAYA MATERI KEBERAGAMAN BUDAYA BANGSA
Authors: Daud Intan Marwah , Ninawati Mimin
Published: December 2022

Abstrak: Penelitian ini bertujuan untuk menghasilkan media pembelajaran yang  berbasis kontekstual pada muatan pelajaran IPS materi keberagaman budaya bangsa siswa kelas IV SDN Gebang Raya 1. Metode yang digunakan dalam penelitian ini yaitu metode Pengembangan atau dikenal dengan Research and Development (R&D) dengan model pengembangan Four D (4D) yang memiliki 4 tahap pengembangan, yaitu: 1) tahap Define (pendefinisian), 2) tahap Design (perancangan), 3) tahap Develop (pengembangan), 4) Dissiminate (penyebaran). Penelitian ini  bertempat di SDN Gebang Raya 1, Tangerang. Adapun subjek penelitian terdiri dari 30 peserta didik kelas IV B di SD tersebut. Pengumpulan data dilakukan dengan angket validasi yang diberikan kepada ahli media, ahli materi, dan peserta didik. Perhitungan data dilakukan dengan teknik kuantitatif dan kualitatif. Hasil dari pengembangan ini adalah media kontekstual Papan Peta Budaya(PAPEDA) materi keberagaman budaya bangsa. Hasil validasi ahli media mendapat skor rata-rata 97% dengan kategori “sangat layak”. Hasil validasi ahli materi mendapat skor rata-rata 94% dengan kategori “sangat layak”. Hasil tanggapan siswa mendapatkan skor rata-rata 90% dengan kategori “sangat layak”. Berdasarkan hasil perolehan dapat disimpulkan bahwa pengembangan media kontekstual Papan Peta Budaya (PAPEDA) materi keberagaman budaya bangsa dikatakan sangat layak sebagai media pembelajaran IPS.Abstract:  This research aims to develop a contextual-based learning media on the content of social studies lesson. This research is included in Research and Development (R&D). This research used the 4D method with four steps, namely:  1)Define stage (Define), 2) Design stage (Design), 3) Develop stage (Development), 4) Dissiminate (spread). This research was held in SDN Gebang Raya 1, Tangerang. The subject of the trial was applied to 30 student of class IV B at the school. Data collection was carried out bye using a validator questionnaire for media expert, material expert and a student response questionnaire. The research data were analyzed using quatitative and qualitative techniques. The results of media expert validation got an average score of 97% in the "very feasible" category. The results of the material expert validation got an average score of 94% in the "very feasible" category. The results of student responses get an average score of 90% with the "very feasible" category. Based on the results, it can be concluded that the development of PAPEDA contextual media (Cultural Map Board) material for the nation's cultural diversity is said to be very feasible as a social studies learning media.
Blood Pressure Variability Among Patients Taking Antihypertensive Drugs in a Tertiary Care Centre in North Kerala
Authors: PM Raveena , Krishnan Kiran , TVP Luluva Muhammed , SS Kiron
Published: December 2022

Introduction: In India, every one in four adults suffers from high blood pressure but a very small percentage of them get properly diagnosed and treated and very few of them go for regular follow-up and monitoring. This is mainly because most people are unaware of the menacing consequences of high BP. Constant monitoring and regular follow-up are crucial to understanding the appropriateness of the provided treatment and making necessary modifications to prevent end organ damage. Aim/Objective: Aim of the study is to evaluate blood pressure variation in patients taking antihypertensive drugs admitted in General Medicine Department of Government Medical College, Kannur. Following are the 2 main objectives; 1. To evaluate and determine the effect of antihypertensive drugs on blood pressure variation. 2. To determine factors associated with variation in BP in hypertensive patients. Methodology: A prospective observational study was done including 33 study subjects, conducted over six months in the Department of General Medicine, Government Medical College, Kannur. All the data was documented and analyzed based on a standard protocol. Results: A total of 33 patients were included in the study, 20 were above the age of 60, and 13 were below the age of 60. Among them 24 were male and 9 were female out of which more than half were classified under stage1 hypertension. It was observed that 24 patients had one or more comorbid conditions like diabetes mellitus, chronic kidney disease, cardiovascular disease, etc., and a majority of the patients were on beta blockers (63.6%) followed by calcium channel blockers (57.6%). Conclusion: Metoprolol in BD dosing and amlodipine in OD dosing provided better control of BP in patients without any comorbidities while they failed to achieve normal BP in patients with comorbid conditions. Comorbid conditions have a significant influence over BPV patterns, hence constant monitoring of BP must be carried out in these patients along with an appropriate treatment plan for better control of BP and to improve the patient’s quality of life.
CHEMICAL PROFILE AND In-vitro BIOLOGICAL ACTIVITIES OF Eupatorium adenophorum SPRENG
Authors: Priya M. Karthigai , K. Poonkodi  , K. Vimaladevi  , V. Anitha  , R. Chitradevi  , E. Jayanthi  , M. Suganthi
Published: December 2022

Eupatorium adenophorum Spreng is an invaded species found in the Western Ghats region, which is used for many diseases in our traditional medicinal system. The essential oil of the plant leaves was examined by Gas chromatography-Mass spectroscopy and evaluated for its biological performance. The antioxidant capacity was found by DPPH radical and ABTs assays. The anticancer activity was determined by MTT assay by using Jurkat E 6.1 cancer cell line along with commercial cancer drug Etoposide. Camphene (11.34%), Bornyl acetate (8.09%), Sabinene (6.75%), Iso borneol (7.96%), were identified as major constituents. It showed remarkable antioxidant performance against DPPH radical and ABTs with IC50 values of 66.7g/mL and70.1g/mL respectively. Essential oil exhibited the strongest cytotoxic effect on Jurkat E6.1cancer cells with an IC50 value of 29g/mL compared to commercial cancer drug Etoposide with an IC50 value of 30g/mL. This one is the first type of report on the chemical constituents of E. adenophorum leaves from the Western Ghats region and its pharmacological activities. E. adenophorum plant is existing throughout the year and is easily available for essential oil isolation.
SYNTHESIS OF SILICON NANOPARTICLES MODIFIED POLYESTER AS MATERIAL ACTIVE ELECTRODE ON A SECONDARY CELL BATTERY
Authors: Andriayani  , Muis Yugia , Nasution Darwin Yunus , Daulay Amru
Published: December 2022

After oxygen, silicon is the second most prevalent element. Despite their abundance, this element is not discovered by itself. Minerals like silicates and aluminum silicates are typically where you can find silicon compounds. This study uses synthesis composite organic-inorganic hybrid resin with a silicon nanoparticles intermediate. Silicon nanoparticles modified polyester can be used as an anode electrode on a secondary cell battery. The characterization XRD of SiNPs showed silicon but contained other impurities such as SiO2, Mg, and MgO. The characterization XRD of SiNPs-PE showed silicon, and a broad peak indicated polyester. The surface area shows SiNPs 70.550 m2 /g and SiNPs-PE 1.064 m2 /g. Pore size showed SiNPs 0.892 nm and SiNPs-PE 1.683 nm. Pore volume showed that SiNPs 0.142 cm3 /g and SiNPs-PE 0.002 cm3 /g. The characterization SEM shows a spherical shape for silicon and a solid surface that shows polyester. The electrical conductivity of SiNPs is 2140,673 µS/cm and resistance 4,671 Ω at 1 V, while the electrical conductivity of SiNPs-PE is 2752,294 µS/cm and resistance 3,633 Ω at 1 V.