bluuebunny/crossref_metadata_2025 huggingface dataset:
Estadiamento do câncer de colo uterino em um hospital de referência
Authors: Da Cunha Fernanda Furtado , Pinheiro Maria da Conceição Nascimento , Corrêa Anderson Roberto de Sales
Published: July 2019

Introdução: O câncer de colo do útero apresenta um dos mais altos potenciais de cura quando diagnosticado e tratado em estágios iniciais ou fases precursoras. O objetivo deste estudo foi avaliar o estadiamento clí­nico do câncer de colo uterino na época do diagnóstico, em um hospital de referência para câncer no Estado do Pará no perí­odo de 2001 a 2010. Métodos: Trata-se de um estudo observacional, retrospectivo, descritivo e analí­tico. A população alvo da pesquisa envolveu mulheres com diagnóstico de câncer de colo do útero constante no Registro Hospitalar de Câncer. As variáveis utilizadas incluí­ram: idade, ocupação, procedência, grau de instrução, diagnóstico histopatológico, estadiamento, local do tumor primário e desfecho. Resultados: As mulheres chegaram í  unidade de referência com estadiamentos clí­nicos avançados (IIB e IIIB), com o carcinoma invasor contribuindo com a maioria dos casos. Os estadiamentos mais frequentes foram IIB, IIIB e IB. Apesar das campanhas de incentivo í  prevenção, a ocorrência do câncer de colo uterino no estádio invasor ainda é muito alta, em detrimento dos casos de carcinoma in situ, os quais foram menos frequentes. Conclusão: As mulheres chegaram í  unidade de referência em estágios avançados do câncer, principalmente nos estadiamentos IIB e IIIB. O carcinoma invasor é o tipo mais frequente contribuindo com 81,4% e o adenocarcinoma invasor com 7,1% do total das lesões malignas do colo. A maior parte das mulheres era maior de 40 anos de idade, de baixa escolaridade e oriundas da região metropolitana de Belém.Palavras-chave: neoplasias do colo do útero, prevenção & controle, estadiamento de neoplasias, papillomaviridae.
Effects of enterostomal therapists training: Evaluated with Kirkpatrick’s model
Authors: Ying Shenlv , Hai-Hong Jiang, , Chen Ai-hua
Published: July 2019

Objective To evaluate the effect of training for enterostomal therapists (ETs) based on Kirkpatrick’s Four Levels of Training Evaluation model. To understand ET trainees' work status after completing the Enterostomal Therapy Nursing Education Program (ETNEP) course as well as the ET students' satisfaction of teachers and studying conditions when completing the Wenzhou ETNEP.
Methods One hundred and sixty-nine students who had completed the Wenzhou ETNEP were evaluated by Kirkpatrick’s Four Levels of Training Evaluation model from four perspectives, namely the Reaction, Learning, Behaviour and Result levels.
Results The overall satisfaction of the Wenzhou ETNEP was high in the Reaction level. In the Reaction Level the average matrix score of training programs and teachers was: >1.4. In the Behavioural level, 103 ETs participated in stoma and wound clinics, with 99.2% of them actively promoting ET nursing knowledge and 18 ETs (13.2%) serving as teachers of ETNEP schools. One hundred and sixteen ETs (85.3%) conducted ET-related nursing courses for other nursing staff and 58.8% of ETs had conducted continued education courses. Of the ETs, 22.8% participated in the hospital’s outpatient or outreach stoma and wound care services. In the Result level, 58.8% of ETs participated in nursing research of the specialty, 29.4% of ETs had obtained scientific research funds and 136 ETs had published papers.
Conclusion Students are satisfied with the ETNEP training they received. Their ability to work and function as ETs has improved on completion of their training. In addition, their professional standing has improved, with all ETNEP participants having achieved good results in the fields of specialised nursing, extended nursing, scientific research and teaching. However, in reviewing the survey results and aligning these with current standards of practice and employment of ETs in China, there is the need to modify parts of the ETNEP (such as raising the degree of ET students' entry criteria), standardise teaching materials and establish communication processes with mechanisms for exchanging ET teachers nationally and internationally, to ensure the quality of teaching and improve the quality of specialised ET nursing.
Science lesson plan evaluation for 7th grade secondary school: A learning process reflection
Authors: Fithriyyati Nilia , Maryani Ika
Published: July 2019

The study aimed to determine the suitability of the Lesson Plan for 7th grade Secondary School with the Learning Process Standard based on the aspects of planning, implementation, and assessment. The particular research was an evaluation research with the CIPP model (Context, Input, Process, and Product). The lesson plan documents were from five schools implementing the Curriculum 2006 and five schools implementing the Curriculum 2013. The respondents were 10 science teachers of 7th grade and 472 students. Data collection instruments were observation guides, questionnaires, interview guides, and documentation. Data analysis techniques were quantitative and qualitative. The Quantitative data was T-score; meanwhile, qualitative data analyzed descriptively. Lesson Plans with the rules of the Curriculum 2006 and Curriculum 2013 were the main documents in the evaluation. The results showed that (1) the suitability of the science lesson plan using KTSP (curriculum 2006) was in category of adequate suitable and lesson plan using K-13 (curriculum 2013) was in suitable category; (2) the suitability of the implementation of science learning using KTSP and K-13 was in category of adequate suitable; and (3) the suitability of the assessment of science learning using KTSP and K-13 was in category of adequate suitable. Generally, the documents of the science lesson plan were adequate suitable with the Learning Process Standards.
The use of controversial public issues with video and macromedia flash player media in civic education learning
Authors: Hermawan Hendra , Samsuri Samsuri , Kurniawati Diah Putri , Sofyaningsih Vinni , Prasetyo Danang
Published: July 2019

The study aimed to find out the effect of controversial public issue learning models with video and Macromedia flash player media on students’ critical thinking skills in Civic Education subjects at SMA Negeri 1 Rancah. The particular research was a quasi-experimental research using pretest, posttest control group design. Data analysis techniques used independent t-test and one-way ANOVA test. The results showed that critical thinking skills on students taught using Controversial Public Issues model with video media had a significant effect on the critical thinking ability. This finding might be seen from the one-way ANOVA test results that the Fcount> Ftable (61.146> 3.13) or the p-value is lower than 0.05 (p = 0.000 <0.05) and the gain score. The experimental class 1 obtained a gain score of 0.49 in the category of "medium" effectiveness. The experimental class 2 obtained a gain score of 0.34 in the category of "medium" effectiveness. The control class obtained a gain score of 0.00 in the category of “low".
Los organismos independientes de control presupuestario : principios, funciones y modelos
Authors: Andrés Jovani Juan Manuel
Published: July 2019

Los déficits públicos han sido persistentes en las últimas décadas, fruto de la crisis del estado de bienestar, y se han exacerbado a raíz de la reciente crisis económica, elevando la deuda pública hasta niveles difícilmente sostenibles. Consecuencia de ello ha sido el desarrollo de marcos institucionales orientados a mejorar el control de las finanzas públicas mediante una mayor transparencia de la información presupuestaria. Este refuerzo institucional resulta especialmente relevante en la nueva gobernanza económica Unión Europea, en cuyo ámbito resulta de fundamental importancia la disponibilidad de información puntual y fiable para facilitar la supervisión mutua y la coordinación de las políticas económicas y presupuestarias. En esta nueva arquitectura institucional, los organismos independientes de control presupuestario están llamados a jugar un papel clave, especialmente en la evaluación de las previsiones económicas sobre las que los gobiernos elaboran los presupuestos y el seguimiento del cumplimiento de las reglas presupuestarias numéricas fijadas para todos los niveles de gobierno.

La reciente creación de la Autoridad Independiente de Responsabilidad Fiscal responde a esta filosofía. Este estudio pretende aportar una aproximación al concepto de lo que genéricamente se denominan en su acepción anglosajona consejos fiscales independientes, a los principios que los inspiran y a los diversos modelos institucionales, con atención especial al ámbito europeo, y ofrecer así elementos de contraste para un análisis del modelo que se propone para dicho organismo.
La Transición energética : sus aspectos jurídicos
Authors: Ruiz-Navarro Pinar José Luis
Published: July 2019

SUMARIO: I.- El derecho de la energía. II.- La normativa del sector eléctrico. III.1. El Convenio internacional creador del MIBEL III. 2. Objetivos del MIBEL. IV.1. El déficit de tarifa. IV.2. ¿Qué hacer con el déficit de tarifa. IV.3. El equilibrio financiero: la Ley 24/2013, del Sector Eléctrico. V.1. Sujetos que participan en la prestación del servicio de suministro eléctrico- V.2. Naturaleza jurídica de las actividades reguladas y actividades libres. VI.- La separación de actividades. Obligación que recae sobre los sujetos que realizan las actividades reguladas (transporte y distribución). VII.- El suministro de energía eléctrica al consumidor final. VIII.- El sector de hidrocarburos.  IX.- La transición energética. X.- ¿Existe una política europea sobre transición energética? XI.- La transición energética en los estados de la Unión Europea. XII.- El caso español ¿un ejemplo a seguir?. XIII.- La eficiencia energética en la Ley 18/2014. XIV.- Los ejes de la política energética española. XV.- Final: por un pacto de la energía. Bibliografía.
Constitución de Hungría : Reformas de 25 de marzo y de 26 de septiembre de 2013
Authors: Daranas Peláez Mariano
Published: July 2019

Análisis de la Constitución de Hungría. Reformas de 25 de marzo y de 26 de septiembre de 2013
Otra iglesia : el sacerdote y diputado republicano Jerónimo García Gallego (1893-1961)
Authors: Moreno Cantano Antonio César
Published: July 2019

Introducción 1.- Un curriculum eclesiástico y cultural excelente: del Seminario a la Catedral del Burgo de Osma. La influencia del obispo Gandásegui. 2.- Director del semanario católico Hogar y Pueblo (1921-1931): pensamiento político, social y religioso. 3.- Defensa de la Iglesia como diputado en la II República: 1931-1936. 4.- La Guerra Civil y su etapa en el exilio en Cuba. Conclusiones. Anexo documental. Fuentes documentales y bibliográficas.
La metódica estructurante del derecho en cuanto convincente concepción superadora de ideales metodológicos
Authors: Villacorta Mancebo Luis Quintín
Published: July 2019

En un sentido diferente a lo propuesto por el positivismo metódico, y desde la aceptación matizada de las premisas hermenéuticas, para la Teoría Estructurante del Derecho la interpretación y la aplicación carecen de autonomía propiamente dicha. Por tanto, desde la Teoría Estructurante del Derecho, la Norma jurídica es entendida como “producto”, y la resolución de cada caso requiere una nueva producción normativa hasta su entrega como Norma de decisión
La participación en el espacio público y su problemática constitucional: breves consideraciones en torno a los "escraches" y a las sentencias sobre el denominado "asedio al Parlamento de Cataluña"
Authors: Ruiz-Rico Ruiz Catalina , Ridao Martín Joan
Published: July 2019

La actual crisis de la representación y de los partidos políticos tradicionales trae causa de la profunda desafección imperante hacia el sistema político, debido tanto a la gestión de la crisis económica e institucional como a la reiteración de episodios de corrupción. En este contexto, los derechos fundamentales de manifestación, reunión y expresión han actuado como vehículo de expresión de no pocas demandas y frustraciones sociales. En concreto, el desplazamiento hacia el espacio público de buena parte de las reclamaciones ciudadanas en forma de “escraches” o de insólitas y multitudinarias protestas ante la institución parlamentaria no sólo revela la deficiente canalización de la participación por conductos institucionalizados sino que ha intensificado la conflictividad política y generado una problemática constitucional que es la que aborda el presente trabajo.
Transparencia, control y privacidad en las relaciones Gobierno-Parlamento: una visión desde el Congreso de los Diputados
Authors: Alba Navarro Manuel
Published: July 2019

Artículo sobre la Ponencia: Transparencia, control y privacidad en las relaciones Gobierno-Parlamento: Una visión desde el Congreso de los Diputados
Las vicisitudes de la jurisdicción especial de hacienda desde 1808 hasta 1823
Authors: Lorenzo Jiménez José Vicente
Published: July 2019

I.- Las vicisitudes de la jurisdicción de hacienda durante la guerra de la independencia. 1. El periodo anterior a la aprobación de la Constitución de 1812. 2. Las innovaciones constitucionales. 3. El desarrollo de las previsiones constitucionales. 4. La Jurisdicción de Hacienda en la zona dominada por Francia. II.- La reacción absolutista. 1. La vuelta de Fernando VII y la restauración de la Jurisdicción de Hacienda. 2. La organización de la Jurisdicción de Hacienda. 3. Las competencias de los órganos de la Jurisdicción de Hacienda. 4. Límites de la Jurisdicción de Hacienda por la calificación de asuntos como gubernativos. 5. Exclusiones de la Jurisdicción de Hacienda. 6. Los conflictos de jurisdicción. III.- La jurisdicción de hacienda durante el Trienio Liberal. 1. La vuelta al sistema de Las Cortes de Cádiz. 2. Los resultados perturbadores de la supresión de la Jurisdicción especial de Hacienda. 3. La reacción frente a las consecuencias de la supresión de la Jurisdicción especial de Hacienda.
En memoria de Pablo Santolaya
Authors: García Roca Javier
Published: July 2019

Notas sobre Pablo Santolaya
Los nuevos enfoques de la ciencia política sobre el Parlamento
Authors: Sánchez de Dios Manuel
Published: July 2019

I.- Introducción. II.- El análisis formalista. III.- El “nuevo paradigma” multifuncional. IV.- El Análisis neoinstitucional. 1. El enfoque de la elección racional. 2. La teoría de juegos. 3. La teoría de la agencia (principal-agente). 4. El enfoque del “agenda setting”. 5. El enfoque histórico. V.- Conclusión. VI.- Bibliografía
A MENTAL REVOLUTION IMPLEMENTATION:
Authors: Yapardy Nirwati
Published: July 2019

Abstract

 The effect of mental revolution training can be observed on individual, and at organizational level. The aims of this study are 1) to investigate the sustainability of participants improvement after mental revolution training; 2) to analyze factors that influence the continuity or discontinuity of the improvements, and lastly, 3) to identify changes that occur after mental revolution training. The research used desciptive qualitative approach. Data were obtained from interviews and documentation on 12 respondents. The results of the study found that from 12 mental revolution projects, only nine projects were still ongoing and three did not reach the initial target. There were three impending factors that affect the continuity and discontinuity, i.e. characteristics of individuals, organizations or work environment (coworkers, superiors, work equipment, and workload), and the last factor was training. Improvements after training were observable from two aspects. First, changes at individual levels. Second, changes on work results or quality of work. However, findings from previous studies found that the sustainability of individual projects only occurred at short-term levels or discontinued when participants completed the training. Factors that influence the sustainability of alumni projects are the quality of change projects, the existence of mid-term and long-term achievement milestones, support from leaders (mentors), mutations and effective teamwork.
PENGARUH BUDAYA ORGANISASI TERHADAP KINERJA APARATUR NAGARI DALAM PENGELOLAAN KEUANGAN NAGARI DI KABUPATEN TANAH DATAR
Authors: Reni Mutia
Published: July 2019

Penelitian ini bertujuan untuk menganalisis pengaruh budaya organisasi terhadap kinerja aparaturnagari dalam pengelolaan keuangan nagari di Kabupaten Tanah Datar. Penelitian ini dilatarbelakangai oleh masih kurang baiknya kinerja aparatur nagari dalam pengelolaan keuangan nagari di Kabupaten Tanah Datar. Penelitian ini menggunakan metode penelitian kuantitatif. Penelitian ini dilakukan terhadap  75 nagari di Kabupaten Tanah Datar dengan jumlah populasi sebanyak  600 responden yang terdiri dari walinagari, sekretaris nagari, bendahara nagari, dan lima kepala urusan nagari. Sample penelitian ini terdiri dari 248 responden yang ditentukan dengan menggunakan rumus Slovin. Penentuan sampel dilakukan dengan menggunakan teknik Multistage Random Sampling. Pengumpulan data penelitian ini menggunakan kuesioner dengan Skala Likert. Data yang diperoleh dianalisis dengan uji regresi linear berganda. Hasil penelitian ini menunjukkan bahwa variabel budaya organisasi, baik secara simultan ataupun secara parsial, berpengaruh secara signifikan terhadap kinerja pengelolaan keuangan nagari di Kabupaten Tanah Datar. Dari hasil penelitian tersebut dapat disimpulkan bahwa budaya organisasi berpengaruh positif terhadap kinerja pengelolaan keuangan nagari di Kabupaten Tanah Datar
ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUHI KEPATUHAN WAJIB PAJAK PADA KANTOR PELAYANAN PAJAK PRATAMA BULUKUMBA
Authors: Santuo Santuo
Published: July 2019

Kepatuhan wajib pajak dipengaruhi oleh beberapa faktor, beberapa diantaranya adalah pemahaman peraturan perpajakan wajib pajak, kualitas pelayanan fiskus dan pemeriksaan pajak. Penelitian ini bertujuan untuk mengetahui pengaruh pemahaman peraturan perpajakan wajib pajak, kualitas pelayanan fiskus dan pemeriksaan pajak terhadap kepatuhan wajib pajak pada Kantor Pelayanan Pajak Pratama Bulukumba. Jumlah sampel yang digunakan sebagai responden pada penelitian ini adalah sebanyak 100 wajib pajak pada Kantor Pelayanan Pajak Pratama Bulukumba. Teknik pengumpulan data menggunakan kuesioner. Analisis data menggunakan analisis regresi linear berganda dengan uji hipotesis parsial dan simultan. Hasil penelitian menunjukkan bahwa terdapat pengaruh yang positif dan signifikan pada pemahaman peraturan perpajakan wajib pajak, kualitas pelayanan fiskus dan pemeriksaan pajak terhadap kepatuhan wajib pajak. Hal ini berarti bahwa kepatuhan wajib pajak pada Kantor Pelayanan Pajak Pratama Bulukumba secara mayoritas dipengaruhi oleh pemahaman peraturan perpajakan wajib pajak, kualitas pelayanan fiskus dan pemeriksaan pajak serta selebihnya dipengaruhi oleh faktor lain yang tidak dimasukkan dalam model penelitian ini.
Impacts of Different Anesthetic Agents on Left Ventricular Systolic Function in Mice Assessed by Echocardiography
Authors: LI C. , DAI J. , WU F. , ZHANG H.
Published: July 2019

The present experiments were performed to study the effects and time trends of different anesthetic agents on the left ventricular (LV) systolic function and heart rate by high-resolution echocardiography in mice. Ten male C57BL/6J mice were submitted to echocardiography imaging separated by 72-hour intervals under the following conditions: 1) conscious mice, 2) mice anesthetized with isoflurane (ISO, inhaled), 3) mice anesthetized with tribromoethanol (TBE, intraperitoneal), 4) mice anesthetized with chloral hydrate (CH, intraperitoneal), and 5) mice anesthetized with pentobarbital sodium (PS, intraperitoneal). The effect of ISO, TBE, CH, and PS on LV systolic function was measured at 0, 1, 2, 3, 4, 6, 8, and 10 min after anesthesia. The results showed that LV systolic function and heart rate (HR) of anesthetized mice were reduced significantly (P<0.05), compared with results in the same mice studied in the conscious state. In addition, the results indicated that the anesthetic with the least effect on LV function was CH, and followed by TBE, PS, ISO. We conclude that different anesthetic agents always depressed the HR and LV systolic function of mice, and, furthermore, the effects and time trends of different anesthetics on LV function are different. In echocardiographic experiments, we should choose proper anesthetic agents according to the experimental requirements.
The Effect of Repeated Whole-Body Cryostimulation on the HSP-70 and Lipid Metabolisms in Healthy Subjects
Authors: LUBKOWSKA A. , BRYCZKOWSKA I. , SZYGULA Z. , GIEMZA C. , SKRZEK A. , ROTTER I. , LOMBARDI G. , BANFI G.
Published: July 2019

The aim of this study was to evaluate the effects of exposure to 30 daily whole body cryostimulation (WBC) on lipid metabolic parameters and serum HSP-70 concentration. The study involved 45 volunteers, homogeneous in terms of diet and daily physical activity. Blood samples were collected before and after the 10th, the 20th, and the 30th session and one month after the intervention. Total cholesterol, HDL, TG concentrations and Apolipoprotein A-I, ApoB and HSP-70 protein levels were determined in serum. Additionally, the LI (Lipid Index) and the LDL level were calculated. During exposure, positive changes in the lipid profile that included a decrease in the TCh, initiated after the 20th WBC session with a simultaneous decrease in TG and LDL levels, and an increase in the HDL concentration were observed. These changes were accompanied by a downward trend in the ApoB concentration and a decrease in the ApoB:ApoA-I ratio after 30 sessions. The nature of these changes persisted for a month after the exposure. The obtained results indicate metabolic benefits that result from prolonged exposure to cryogenic temperatures, confirming the postulate of using WBC in the regulation of lipid metabolism and the prevention of cardiovascular diseases.
Tempol Alleviates Chronic Intermittent Hypoxia-Induced Pancreatic Injury Through Repressing Inflammation and Apoptosis
Authors: WANG Y. , AI L. , HAI B. , CAO Y. , LI R. , LI H. , LI Y.
Published: July 2019

Obstructive sleep apnea (OSA) has been demonstrated to be implicated in disorder of insulin secretion and diabetes mellitus. In this study, we aimed to evaluate the protective role of tempol, a powerful antioxidant, in chronic intermittent hypoxia (IH)-induced pancreatic injury. The rat model of OSA was established by IH exposure. The pathological changes, increased blood-glucose level, and raised proinsulin/insulin ratio in pancreatic tissues of rats received IH were effectively relieved by tempol delivery. In addition, the enhanced levels of pro-inflammatory cytokines, TNF-α, IL-1β, IL-6, and inflammatory mediators, PGE2, cyclooxygenase-2 (COX-2), NO, and inducible nitric oxide synthase (iNOS) in pancreatic tissue were suppressed by tempol. Moreover, tempol inhibited IH-induced apoptosis in pancreatic tissue as evidenced by upregulated Bcl-2 level, and downregulated Bax and cleaved caspase-3 levels. Finally, the abnormal activation of mitogen-activated protein kinase (MAPK) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling pathways induced by IH was restrained by tempol administration. In summary, our study demonstrates that tempol relieves IH-induced pancreatic injury by inhibiting inflammatory response and apoptosis, which provides theoretical basis for tempol as an effective treatment for OSA-induced pancreatic injury.
Assessment of Platelet Respiration as Emerging Biomarker of Disease
Authors: PETRUȘ A. , LIGHEZAN D. , DĂNILĂ M. , DUICU O. , STURZA A. , MUNTEAN D. , IONIȚĂ I.
Published: July 2019

Mitochondrial dysfunction is currently acknowledged as a central pathomechanism of most common diseases of the 21st century. Recently, the assessment of the bioenergetic profile of human peripheral blood cells has emerged as a novel research field with potential applications in the development of disease biomarkers. In particular, platelets have been successfully used for the ex vivo analysis of mitochondrial respiratory function in several acute and chronic pathologies. An increasing number of studies support the idea that evaluation of the bioenergetic function in circulating platelets may represent the peripheral signature of mitochondrial dysfunction in metabolically active tissues (brain, heart, liver, skeletal muscle). Accordingly, impairment of mitochondrial respiration in peripheral platelets might have potential clinical applicability as a diagnostic and prognostic tool as well as a biomarker in treatment monitoring. The aim of this minireview is to summarize current information in the field of platelet mitochondrial dysfunction in both acute and chronic diseases.
Electroacupuncture Enhances Antioxidative Signal Pathway and Attenuates Neuropathic Pain Induced by Chemotherapeutic Paclitaxel
Authors: ZHAO X. , LIU L. , WANG Y. , WANG G. , ZHAO Y. , ZHANG Y.
Published: July 2019

One of the significant limiting complications of paclitaxel is painful peripheral neuropathy during its therapy for several types of cancers. Our recent study showed that impairment of Nrf2-antioxidant response element (Nrf2-ARE) and upregulation of oxidative signals in the dorsal root ganglion (DRG) of rats with treatment of paclitaxel result in neuropathic pain. The purpose of this study was to examine the beneficial role played by electroacupuncture (EA) in modifying neuropathic pain evoked by paclitaxel via Nrf2-ARE and oxidative mechanisms. Behavioral test was performed to determine mechanical and thermal sensitivity in rats. Western Blot analysis and ELISA were used to examine expression of Nrf2-ARE and superoxide dismutases (SOD); and the levels of products of oxidative stress in the DRG. Our data showed that paclitaxel increased mechanical and thermal sensitivity and this was accompanied with impaired Nrf2-ARE and SOD in the DRG and amplified products of oxidative stress (i.e. 8-isoprostaglandin F2α and 8-hydroxy-2’-deoxyguanosine). EA treatment largely restored the levels of Nrf2-ARE/SOD and inhibited products of oxidative stress and thereby attenuated mechanical and thermal hypersensitivity induced by paclitaxel. In conclusion, we revealed specific signaling pathways leading to paclitaxel-evoked neuropathic pain, including impairment of Nrf2-ARE and heightened oxidative signals. We further provided evidence for the role of EA in alleviating paclitaxel-neuropathic pain via these molecular mediators.
Sistem Keamanan Jaringan Local Area Network Menggunakan Teknik De-Militarized Zone
Authors: Anugrah Ino , Rahmanto Raden Hengki
Published: July 2019

ABSTRACT

 

Islamic University”45” computer network needs a safe network to strengthen the network security systems to protect servers from attacks such as Port Scanning and DoS attack (Denial of Service). One of the network security techniques is De-Militarized Zone (DMZ) that is a mechanism to protect the internal system from hacker attacks or other parties who want to enter the system with no access. The purpose of this Project is to implement LAN network security system using De-Militarized Zone (DMZ) technique, with a single firewall that supports the internal and external networks. The results of the DMZ technique implementation at the Islamic University's "45", it is found that filter DoS attack can be implemented well.  Data analysis results show DoS attack with the type of ICMP Flooding attack, and UDP Flooding attack can be blocked with Percentage of success is 98%.

 

Keywords : attack, network security,  de-militarized zone

 

 

ABSTRAK

 

Jaringan komputer Universitas Islam “45” memerlukan keamanan jaringan untuk dapat memperkuat sistem keamanan jaringan pada server dari serangan seperti Port Scanning dan DoS (Denial of Service). Salah satu teknik keamanan jaringan yaitu De-Militarized Zone (DMZ) yang merupakan mekanisme untuk melindungi sistem internal dari serangan hacker atau pihak-pihak lain yang ingin memasuki sistem tanpa mempunyai hak akses. Tujuan Tugas Akhir ini adalah untuk mengimplementasikan sistem keamanan jaringan LAN menggunakan teknik De-Militarized Zone (DMZ). metode dasar adalah dengan menggunakan firewall tunggal yang menjadi penyangga jaringan internal dan external. Hasil penelitian implementasi teknik DMZ pada layanan server jaringan komputer Universitas Islam “45” dapat melakukan filter DoS attack dengan baik, data hasil analisa  menunjukan DoS attack dengan jenis ICMP Flooding attack, dan UDP Flooding attack dapat di-block dengan Persentase keberhasilan sebesar 98%.

 

Kata kunci : Serangan,  Keamanan jaringan,  De-Militarized Zone
Hypoxia Hangover and Flight Performance After Normobaric Hypoxia Exposure in a Hawk Simulator
Authors: Varis Nikke , Parkkola Kai I. , Leino Tuomo K.
Published: July 2019

INTRODUCTION: The incidence of hypoxia-like symptoms in military aviators is on the rise. Cases can be related to On-Board Oxygen Generating System (OBOGS) malfunction, air contamination, loss of cabin pressurization, hyperventilation, or a combination of these issues simultaneously.
Normobaric hypoxia training in tactical fighter simulations has been conducted in the Finnish Air Force since 2008. This training helps aviators to recognize their individual hypoxia symptoms and refreshes hypoxia emergency procedures in a realistic cockpit.METHODS: A flight mission
included three set-ups and a return to base (RTB) after the third set-up. In a tactical Hawk simulator, different concentrations of oxygen were used (8%, 7%, and 6% oxygen in nitrogen) to create normobaric hypoxia exposures. During the RTB, the flight instructor evaluated the subjects’
flight performance (N = 16) in order to estimate cognitive functions after hypoxia. A control flight was evaluated before or after the flight with normobaric hypoxia exposure.RESULTS: Instrumental flight rule performance during RTB decreased significantly from 4.81 to 3.63
after normobaric hypoxia and emergency procedures. Some pilots reported fatigue, headache, memory problems, and cognitive impairment as adverse effects up to 12 h after normobaric hypoxia training.DISCUSSION: Hypoxia has a significant effect on flight performance during RTB, even
10 min after hypoxia emergency procedures. Since 100% oxygen was used as emergency oxygen, as in a real aircraft, the oxygen paradox may decrease flight performance. Hypoxia training in tactical fighter simulations provides an opportunity for pilots to also understand the effects of the “hypoxia
hangover” on their flight performance.Varis N, Parkkola KI, Leino TK. Hypoxia hangover and flight performance after normobaric hypoxia exposure in a Hawk simulator. Aerosp Med Hum Perform. 2019; 90(8):720–724.
Continuous Glucose Monitoring for In-Flight Measurement of Glucose Levels of Insulin-Treated Pilots
Authors: Strollo Felice , Simons Ries , Mambro Andrea , Strollo Giovanna , Gentile Sandro
Published: July 2019

INTRODUCTION: Due to the risk of hypoglycemia-related incapacitation, diabetic pilots requiring insulin are assessed as unfit according to the International Civil Aviation Organization and most national authorities. Some authorities, such as those from Canada, the United Kingdom,
and the United States, permit selected insulin-treated pilots (ITDM-pilots) to fly subject to a protocol requiring pre- and in-flight capillary glucose measurements to show safe levels (>100–<300 mg · dl−1). Critics of such permission question the practicability
of these in-flight measurements and whether clinically desired glycemic targets can be achieved while keeping glucose levels in the safe range. Subcutaneous continuous glucose monitoring (CGM) has recently been approved by the FDA as a stand-alone method to provide accurate glucose levels
and treatment decision guidance in patients. This commentary considers that use of CGM by ITDM pilots facilitates practicability and recording of in-flight glucose measurements and facilitates achievement of clinically desired glycemic targets without increasing hypoglycemia risks.Strollo
F, Simons R, Mambro A, Strollo G, Gentile S. Continuous glucose monitoring for in-flight measurement of glucose levels of insulin-treated pilots. Aerosp Med Hum Perform. 2019; 90(8):735–737.
The effect of academic and pedagogic competences on basic teaching skills of mathematics teacher candidates in micro teaching
Authors: Dirgantoro Kurnia Putri Sepdikasari
Published: July 2019

Keterampilan mengajar merupakan salah satu keterampilan dasar yang harus dikuasai oleh seorang guru. Oleh karenanya, mahasiswa calon guru perlu terus menerus melatih diri untuk mengembangkan keterampilan mengajarnya. Salah satu cara yang diusahakan adalah melalui pengajaran mikro pada mata kuliah PSAP (Perencanaan, Strategi, Asesmen, Pembelajaran) Matematika. Tujuan penelitian ini adalah untuk mengetahui kontribusi dari kemampuan akademik dan pedagogik mahasiswa calon guru terhadap keterampilan dasar mengajar mereka dalam pengajaran mikro. Subjek penelitian terdiri dari 56 mahasiswa prodi Pendidikan Matematika Universitas Pelita Harapan angkatan 2017. Penelitian ini merupakan penelitian korelasional dan analisis regresi linear sederhana. Instrumen yang digunakan dalam pengumpulan data meliputi rubrik pengajaran mikro, arsip nilai mahasiswa, dan kuesioner. Hasil penelitian ini adalah: (1) terdapat korelasi yang signifikan antara kemampuan akademik dan keterampilan dasar mengajar; (2) terdapat pengaruh yang signifikan dari kemampuan akademik terhadap keterampilan dasar mengajar; (3) terdapat korelasi yang signifikan antara kemampuan pedagogik dan keterampilan dasar mengajar; serta (4) terdapat pengaruh yang signifikan dari kemampuan pedagogik terhadap keterampilan dasar mengajar. Ini berarti, mata kuliah pedagogi dan konten dasar matematika yang diberikan sudah sesuai dengan kebutuhan mahasiswa.
ANALISIS DIMENSI PELAYANAN YANG PERLU DIPERHATIKAN UNTUK MENCAPAI KEPUASAN PELANGGAN KLP.”Sinar Rinjani“ AIKMEL
Authors: Syafhariawan Herry , Netrawati I Gusti Ayu Oka
Published: July 2019

Penelitian ini bertujuan untuk mengetahui dimensi pelayanan yang perlu diperhatikan untuk mencapai kepuasan pelanggan apakah dimensi berwujud, keandalan, daya tanggap, jaminan atau empati. dan untuk mengetahui tingkat kepuasan pelanggan terhadap pelayanan yang diberikan oleh KLP. “Sinar Rinjani “ Aikmel. Metode pengumpulan data yang digunakan adalah metode sampel survey, dan teknik pengumpulan datanya melalui wawancara dan dokumentasi. Penentuan jumlah responden menggunakan rumus slovin, kemudian untuk pengambilan sampel menggunakan metode proportional stratified random sampling. Adapun alat analisis yang digunakan adalah analisis tabel frekwensi, penentuan indeks konsumen / pelanggan ( IPK ), dan analisis diagram kartesius, atribut pelayanan yang dikaji terdiri dari 15 ( lima belas) atribut pelayanan dari 5 ( lima ) dimensi pelayanan.Berdasarkan analisis data ditentukan bahwa pada setiap atribut pelayanan dari dimensi pelayanan, pelanggan mempunyai lima tingkat kepentingan yaitu menyatakan atribut pelayanan sangat penting, penting, cukup penting, kurang  penting dan tidak penting. Sedangkan pada kinerja aktual KLP. “ Sinar Rinjani “ Aikmel terdapat lima tanggapan yaitu tidak baik, kurang baik, cukup baik, baik dan sangat baik. Selanjutnya dengan menggunakan analisis tabel frekwensi dapat diketahui bahwa empat atribut yang tidak memuaskan pelanggan. Kemudian atas dasar indeks kepuasan konsumen, atribut yang tidak memuaskan pelanggan adalah fasilitas lain-lain.Kesimpulannya adalah Pelanggan KLP “Sinar Rinjani”,Aikmel tergolong tidak puas dan dimensi pelayanan yang berwujud perlu diperhatikan dan diperbaiki. Disarankan kepada manajemen perusahaanu untuk  layanan dan yang perlu diperbaiki oleh KLP. “ Sinar Rinjani adalah sebanyak 12 ( dua belas ) atribut layanan
ANALISIS YURIDIS PELAKSANAAN RENCANA TATA RUANG WILAYAH BERDASARKAN PERATURAN DAERAH NOMOR 12 TAHUN 2011 SEBAGAIMANA TELAH DIUBAH DENGAN PERATURAN DAERAH NOMOR 5 TAHUN 2019 TENTANG RENCANA TATA RUANG WILAYAH KOTA MATARAM TAHUN 2011-2031
Authors: Safrudin Safrudin , Arba Arba , Sahnan Sahnan
Published: July 2019

Tujuan penelitian ini adalah untuk menjawab pertanyaan bagaimanakedudukan dan perlindungan hukum serta penyelesaian permasalahan yang timbul setelah berlakunya PerdaNomor 12 Tahun 2011 tentang Rencana Tata Ruang Wilayah Kota Mataram Tahun 2011-2031 (Perda RTRW Kota MataramTahun 2011-2031). Jenis penelitian ini adalah penelitian empiris. Dengan menggunakan pendekatan perundang-undangan, konseptual dan sosiologis. Pengumpulan data dilakukan dengan studi kepustkaan dan studi lapangan dengan menggunakan teknik wawancara. Setelah data-data tersebut diperoleh, maka dianalisis dengan kajian deskriptif kualitatif yang menggunakan logika berfikir induktif atau berangkat dari hal-hal yang khusus untuk mendapatkan kesimpulan yang umum. Kedudukan Izin Mendirikan Bangunan (IMB)tidak memiliki kekuatan hukumapabila belum adanya penyesuaian dengan Perda tersebut walaupun pemanfaatan ruang yang sah menurut rencana tata ruang dandapat dibuktikan bahwa izin tersebut diperoleh sesuai dengan prosedur yang benar. Bentuk perlindungan hukum terhadap pemilik bangunan yang berdiri sebelum berlakunya Perda RTRW Kota Mataram Tahun 2011-2031 yaitu berupa pemberian masa transisi selama 3 (tiga) tahun untuk penyesuaian dan kepada pemegang izin diberikan penggantian yang layak berdasarkan amanat Pasal 77 Undang-Undang Tentang Pemanfaatan Ruang.Ada 2 cara yang dilakukan dalam penyelesaian terhadap pelanggaran Perda RTRW Kota Mataram Tahun 2011-2031 yaitudengan cara non litigasi melalui proses negosiasi dan cara litigasi
KAJIAN TENTANG POTENSI DAYA TARIK WISATA SYARIAH DI PULAU LOMBOK
Authors: Rozita Rozita , Suprianto Andi , Mahdani Mahdani , Masyhudi Lalu , Kurniansah Rizal
Published: July 2019

Wisata syariah adalah wisata yang mengedepankan nilai islam dalam setiap aktivitasnya, wisata syariah itu sendiri memiliki arti yang lebih luas yaitu pariwisata yang keseluruhannya tidak bertentangan dengan syariah islam misalkan keberadaan hotel, restoran, trasnportasi, fasilitas ibadah dan obyek wisata itu sendiri yang tidak bertentangan dengan syariah islam. Pulau Lombok sendiri memiliki potensi untuk dijadikan destinasi wisata syariah di Indonesia. Pada tahun 2015, Lombok pernah meraih 2 penghargaan yaitu best World Halal Tourism Destination dan World Best Halal Honeymoon Destination. Kedua penghargaan tersebut menjadi bukti, bahwa pulau Lombok memang menjadi primadona bagi para wisatawan untuk berlibur di Lombok. Pengembangan pariwisata di pulau Lombok masih terfokuskan pada pengembangan pariwisata alam dan budayannya. Sedangkan wisata Syariah belum terlalu berkembang secara maksimal sedangkan potensi untuk dikembangkannya wisata Syariah di pulau Lombok cukup terbuka.Penelitian ini bertujuan untuk mendeskripsikan potensi daya tarik wisata syariah di pulau lombok dan mendeskripsikan ketersediaan komponen produk pendukung wisata syariah di pulau Lombok. Teknik pengumpulan data yang digunakan yaitu observasi, wawancara, studi pustaka dan dokumentasi. Sedangkan analisis data yang digunakan yaitu analasis data deskriptif kualitatif. Berdasarkan hasil penelitian yang dilakukan yaitu potensi daya tarik wisata syariah di pulau Lombok telah tersedia antara lain Makam Bintaro, Masjid Islamic Center, Pantai tanjung karang, Festival Ngejot, Acara Adat Tiu Jantuk, Makam Selaparang dan Masjid Bayan Beleq, Upacara Adat Ngayu-ayu. Sedangkan ketersediaan komponen produk pendukung wisata syariah di pulau telah tersedia meskipun masih perlu ditingkatkan lagi keberadaannya. Adapun komponen pendukung tersebut antara lain hotel syariah (Hotel Grand Madani Lombok), Kondisi Jalan sudah baik, dan didukung pelayanan taksi konvensi dan online yaitu Gojek dan Grab. Serta pelayanan pendukung yang terorganisasi seperti Dinas Pariwisata Kabupaten Lombok Utara, Mataram, Lombok Tengah, Lombok Timur dan Lombok Barat dengan berkoordinasi dengan Dinas Pariwisata Provinsi NTB. Peran lain dari pemerintah yaitu mengupayakan disetiap daya tarik wisata syariah di suatu desa membentuk salah satu kelompok sadar wisata (Pokdarwis) untuk mengelola daya tarik wisata syariah di desa masing-masing.
Directions for improving internal audit methods of expenses
on enterprises business payment
Authors: Susidenko Yuliіa
Published: July 2019

The purpose of the article is to summarize and critically evaluate the current theoretical positions, methodologies, organization and practices of accounting and audit of labor costs, develop recommendations for their improvement and practical use for the adoption of sound accounting and management decisions at leading enterprises of Ukraine in modern economic conditions. The main directions of improvement of the methodology of audit of labor costs are considered, it is proved that wages are one of the factors of the efficiency of the enterprise, since the size of the accrued wages, the timeliness and completeness of settlements with employees affects the quality of work of hired workers and the amount of expenses of the enterprise. It is proved that one of the main factors influencing the effective activity and competitiveness of the enterprise is the cost of labor remuneration. For the employer company, the wages of its employees are one of the most important items of expenditure. In the current difficult economic situation in Ukraine, issues relating to the payment of labor citizens is one of the most important places. Introduction of new systems and forms of remuneration, automation of accounting and auditing, introduction of electronic document management is a prerequisite for further development of business and competitiveness in the labor market, along with growing labor migration abroad. The methodology of the research is to use the fundamental provisions of modern economic science, scientific works of domestic and foreign scientists on the issue of ensuring the totality of theoretical, methodological and practical aspects of accounting and auditing of labor costs. The scientific novelty of the obtained results consists in theoretical substantiation and development of methodical approaches and practical recommendations for improving accounting and auditing of labor costs of enterprises. Conclusions. One of the main factors influencing the effective activity and competitiveness of the enterprise is the cost of labor remuneration. For the employer company, the wages of its employees are one of the most important items of expenditure. For the improvement of the system of wages and employee motivation, a flexible model based on performance criteria is proposed, which will increase the interest of employees in individual indicators as well as in the final results of the work of the business entity.
Fiscal obligations of the subsoil users
Authors: Bodiuk Adam
Published: July 2019

The article of research is operating financial relations of subsoil users before the state for mining, exploitation of underground space and system of forming of monetary resources for a budget after the Internal revenue code of Ukraine. The aim of writing of the article is development after resource approach of concept vehicle and mechanism of input of payments on the fiscal obligations of subsoil users. Methodology of realization of work is application of abstractly-logical, system-structural and comparative analysis (for forming of the system and mech- anism of forming of fiscal obligation of subsoil users); to the analysis (research of right base of production of paying is for using the bowels of the earth); mono- graphic analysis (at application of resource approach); generalization (forming of the system of bills of debt is before the state); interpretation (application of tran- sition from fiscal payments to the budgetary resources from position of more generalized concept; fiscal resources ). Job performances – reasonably: resource approach is to forming of profits of the state budget; system of bills of debt of subsoil users before the state; name of operating pay in different forms for using the bowels of the earth for mining after her essence by a subsoil fiscal profit as to payment of subsoil users, that is brought in by them in the state budget; actu- ality of replacement far of past origin of concept of taxes is on fiscal obligations for using the bowels of the earth; concept of money, fiscal, budgetary resources. Conclusions – instead of the operating system of taxes it is necessary to enter payments on the fiscal obligations of subsoil users for using the bowels of the earth for mining and using underground space, with bringing of these inputs in the Internal revenue code of Ukraine.
LUPUS PANNIKULITIS PADA ANAK: PENEGAKAN DIAGNOSIS UNTUK KASUS JARANG
Authors: Dewi Nadia Akita , Pudjiati Satiti Retno , - Sunardi Radiono , - Retno Danarti
Published: July 2019

Lupus pannikulitis (LP), suatu variasi klinis kulit yang jarang pada lupus eritematosus kutan, jarang terjadi pada anak. Perjalanan penyakit lambat sehingga penegakan diagnosis sering terlambat.Anak laki-laki 13 tahun mengeluh area cekung pada wajah sejak usia 11 tahun diikuti cekung pada kepala. Benjolan sewarna kulit pada kedua lengan dirasakan selama 1 bulan. Terdapat atrofi pada kedua pipi dengan tepi lesi dikelilingi bercak merah keunguan. Pada skalp tampak alopesia dengan atrofi multipel, dikelilingi bercak eritematosa di tepinya. Pada kedua lengan atas terdapat nodul subkutan sewarna kulit, multipel, perabaan keras, dan tidak nyeri. Pemeriksaan histopatologis lesi wajah dan skalp dengan pewarnaan HE didapatkan ortokeratosis linear dengan sumbat keratotik pada epidermis. Pada dermis atas terdapat sebukan sel radang didominasi limfosit, dermis tengah kolagenisasi hingga jaringan subkutan, tampak sel radang pada jaringan subkutan septal-lobular dengan dominasi limfosit dan nekrosis lemak. Pewarnaan alcian blue ditemukan deposit musin pada dermis. Lupus band test ditemukan deposit IgG pada membran basalis.Lesi pada LP sulit dibedakan dengan pannikulitis lainnya, misalnya morfea profunda, karena keduanya menujukkan lesi lipoatrofi didahului nodus subkutan. Pannikulitis septal-lobular dan nekrosis lemak dengan deposit musin pada dermis merupakan gambaran histopatologis khas untuk LP. Lupus band test perlu dilakukan untuk membantu membedakan diagnosis LP dengan pannikulitis lainnya.Kata kunci: Lupus pannikulitis, lupus band test.
KORTIKOSTEROID INTRALESI: ASPEK FARMAKOLOGIK DAN PENGGUNAAN KLINIS DI BIDANG DERMATOLOGI
Authors: - Rianyta , - Purwantyastuti , Menaldi Sri Linuwih , Paramitha Larisa
Published: July 2019

Injeksi kortikosteroid intralesi telah digunakan untuk mengobati berbagai penyakit dalam bidang dermatologi dengan hasil yang bervariasi. Dalam dermatologi biasanya digunakan untuk keloid, dermatosis inflamasi (prurigo nodularis, liken simpleks kronik), alopesia areata, akne vulgaris, dan hemangioma. Berbeda dengan kortikosteroid topikal, pada kortikosteroid intralesi, obat akan melewati penghalang dari stratum korneum yang tebal sehingga menjadi bahan antiinflamasi yang poten. Tujuan injeksi intralesi adalah untuk mencapai konsentrasi obat yang tinggi di lokasi yang sakit dengan absorpsi sistemik minimal, sehingga terhindar dari berbagai efek samping yang berkaitan dengan pemberian sistemik. Kortikosteroid menekan inflamasi dan mitosis, sekaligus meningkatkan vasokonstriksi di daerah lesi. Beberapa efek samping lokal (atrofi kulit, perdarahan, nyeri akibat suntikan, ulserasi, infeksi sekunder, dan reaksi alergi) serta sistemik (supresi sumbu hipotalamus-hipofisis-adrenal, hambatan pertumbuhan, sinkop, kebutaan, dan gangguan endokrin) telah dilaporkan akibat injeksi intralesi, tetapi efek samping tersebut jarang terjadi (karena diberikan dalam dosis kecil) atau dapat diterima. Oleh karena itu, injeksi kortikosteroid intralesi merupakan bagian yang tak terpisahkan dalam praktik klinis dermatologi.Kata kunci: dermatologi, injeksi, kortikosteroid intralesi, praktik klinis