bluuebunny/crossref_metadata_2025 huggingface dataset:
Current and Emerging Molecular Therapies for Head and Neck Squamous Cell Carcinoma
Authors: Kordbacheh Farzaneh , Farah Camile S.
Published: November 2021

Head and neck cancer affects nearly 750,000 patients, with more than 300,000 deaths annually. Advances in first line surgical treatment have improved survival rates marginally particularly in developed countries, however survival rates for aggressive locally advanced head and neck cancer are still poor. Recurrent and metastatic disease remains a significant problem for patients and the health system. As our knowledge of the genomic landscape of the head and neck cancers continues to expand, there are promising developments occurring in molecular therapies available for advanced or recalcitrant disease. The concept of precision medicine is underpinned by our ability to accurately sequence tumour samples to best understand individual patient genomic variations and to tailor targeted therapy for them based on such molecular profiling. Not only is their purported response to therapy a factor of their genomic variation, but so is their inclusion in biomarker-driven personalised medicine therapeutic trials. With the ever-expanding number of molecular druggable targets explored through advances in next generation sequencing, the number of clinical trials assessing these targets has significantly increased over recent years. Although some trials are focussed on first-line therapeutic approaches, a greater majority are focussed on locally advanced, recurrent or metastatic disease. Similarly, although single agent monotherapy has been found effective in some cases, it is the combination of drugs targeting different signalling pathways that seem to be more beneficial to patients. This paper outlines current and emerging molecular therapies for head and neck cancer, and updates readers on outcomes of the most pertinent clinical trials in this area while also summarising ongoing efforts to bring more molecular therapies into clinical practice.
Molecular Biomarkers Predict Pathological Complete Response of Neoadjuvant Chemotherapy in Breast Cancer Patients: Review
Authors: Freitas Ana Julia Aguiar de , Causin Rhafaela Lima , Varuzza Muriele Bertagna , Hidalgo Filho Cassio Murilo Trovo , Silva Vinicius Duval da , Souza Cristiano de Pádua , Marques Márcia Maria Chiquitelli
Published: November 2021

Neoadjuvant chemotherapy (NAC) is often used to treat locally advanced disease for tumor downstaging, thus improving the chances of breast-conserving surgery. From the NAC response, it is possible to obtain prognostic information as patients may reach a pathological complete response (pCR). Those who do might have significant advantages in terms of survival rates. Breast cancer (BC) is a heterogeneous disease that requires personalized treatment strategies. The development of targeted therapies depends on identifying biomarkers that can be used to assess treatment efficacy as well as the discovery of new and more accurate therapeutic agents. With the development of new “OMICS” technologies, i.e., genomics, transcriptomics, and proteomics, among others, the discovery of new biomarkers is increasingly being used in the context of clinical practice, bringing us closer to personalized management of BC treatment. The aim of this review is to compile the main biomarkers that predict pCR in BC after NAC.
Tumor Doubling Time Using CT Volumetric Segmentation in Metastatic Adrenocortical Carcinoma
Authors: Fuller Sarah N. , Shafiei Ahmad , Venzon David J. , Liewehr David J. , Mauda Havanuk Michal , Ilanchezhian Maran G. , Edgerly Maureen , Anderson Victoria L. , Levy Elliot B. , Hoang Choung D. , Jones Elizabeth C. , Reilly Karlyne M. , Widemann Brigitte C. , Wood Bradford J. , Bagheri Hadi , Del Rivero Jaydira
Published: November 2021

Adrenocortical carcinoma (ACC) is a rare malignancy with an overall unfavorable prognosis. Clinicians treating patients with ACC have noted accelerated growth in metastatic liver lesions that requires rapid intervention compared to other metastatic locations. This study measured and compared the growth rates of metastatic ACC lesions in the lungs, liver, and lymph nodes using volumetric segmentation. A total of 12 patients with metastatic ACC (six male; six female) were selected based on their medical history. Computer tomography (CT) exams were retrospectively reviewed and a sampling of ≤5 metastatic lesions per organ were selected for evaluation. Lesions in the liver, lung, and lymph nodes were measured and evaluated by volumetric segmentation. Statistical analyses were performed to compare the volumetric growth rates of the lesions in each organ system. In this cohort, 5/12 had liver lesions, 7/12 had lung lesions, and 5/12 had lymph node lesions. A total of 92 lesions were evaluated and segmented for lesion volumetry. The volume doubling time per organ system was 27 days in the liver, 90 days in the lungs, and 95 days in the lymph nodes. In this series of 12 patients with metastatic ACC, liver lesions showed a faster growth rate than lung or lymph node lesions.
The Free-of-Charge Phenomena in the Network Economy—A Multi-Party Value Exchange Model
Authors: Lin Ya-Wen , Lin Tsung-Xian , Farn Cheng-Kiang
Published: November 2021

The long-standing economic model is one where customers receive and pay for goods and services. However, in today’s modern network economy, why are vendors willing to provide free services and goods to free-riders at an apparent loss? The objective of this study is to provide a theoretical framework explaining why free network services emerge and how they work. This study adopted the multi-case study method, summarized 28 types of revenue model patterns from 51 indicative free network services, and inferred the causes for the antecedent conditions of each revenue model with Qualitative Comparative Analysis (QCA), in order to confirm the causal relationship between the various antecedent conditions, configurations, and revenue models as conclusive evidence. In addition, this study established seven conditional propositions via their links with related theories, which were taken as the basis for providing in-depth explanations of the revenue model of the free network service, and expanded the demonstration of the original network economy.
Consumer Marketing Strategy and E-Commerce in the Last Decade: A Literature Review
Authors: Rosário Albérico , Raimundo Ricardo
Published: November 2021

E-commerce is deemed as the sale and purchase of goods and services through the internet in exchange for money and data transfer to complete the transactions. E-commerce is at the forefront of transforming marketing strategies, based on new technologies, and facilitates product information and improved decision-making. In this way, marketing strategy increasingly require large amounts of information to better understand client needs, which raises the question of choosing the right marketing strategy to better fit consumer expectations. This literature review aims to shed light on both the recent growth of e-commerce literature and its interplay with consumer marketing strategy. Extant research has examined this change in human interaction due to social network building, mostly through the themes of online marketing and social media marketing, also comprehending issues such as cost efficiency, information quality and trust development towards online shopping. Nevertheless, existing research has not shown in full all the research streams, how they interact with each other and its potential knowledge development. Thus, a literature review on consumer marketing strategy for e-commerce in the last decade is opportune. This paper aims to identify research trends in the field through a Systematic Bibliometric Literature Review (LRSB) of research on marketing strategy for e-commerce. The review includes 66 articles published in the Scopus® database, presenting up-to-date knowledge on the topic. The LRSB results were synthesized across current research subthemes. The following findings are presented: Amidst the current competitive global business environment, companies tend to respond with strategies for e-commerce and online businesses that resort to e-commerce platforms and social networking to better understand consumer needs, facilitate consumer marketing strategy and share innovative information. The originality of the paper relies on its LRSB method, together with extant review of articles that have not been categorized so far.
Structure of technical service in agro-industrial complex
Authors: Gradov E. A.
Published: November 2021

The article deals with the issues of modern technical service and its organizational system in the system of engineering and technical support of the agro-industrial complex. The efficiency of agricultural production is mainly influenced by the level of organization in the technical service industry.
PROBLEMS AND PROSPECTS OF STEM EDUCATION IMPLEMENTATION IN UKRAINE
Authors: Ovchatova Anastasia
Published: November 2021

It has been established that despite significant obstacles and stereotypes regarding the introduction of STEAM education in Ukraine, this process is inevitable, as leading Ukrainian educators claim that the previous Soviet concept of education is utopian and ineffective. It is determined that if Ukraine aspires to become a leading European state, then changing the education system is the main factor of success. It is stated that in the conditions of transition to the New modernized Ukrainian school the introduction of STEM education remains the most priority direction of the educational system of Ukraine. It is determined that due to the consolidation of efforts the introduction of STEAM education is becoming one of the real goals of the New Ukrainian School. Only in the last few years, the legal framework for the implementation of STEAM in Ukraine has been created, the Web-STEAM-school is working, the collection of materials "STEM-week" is published, scientific conferences are systematically held, a virtual STEM-center is opened, which is a huge step forward.
Penstabilan Suhu Pengeringan Kopi dengan Kontrol Logika Fuzzy
Authors: Al Arif Rangga
Published: November 2021

Pengeringan kopi metode konvensional yaitu dengan cara dijemur di bawah sinar matahari langsung memiliki kekurangan yaitu suhu lingkungan yang tidak bisa diprediksi, untuk mendapat hasil pengeringan gabah yang optimal, maka dibuat sebuah mesin pengering dengan sistem rotary, penstabilan kopi juga sangat penting saat proses pengeringan, suhu yang fluktuatif akan berpengaruh pada hasil pengeringan gabah, karena itu ditetapkan sebuah set poin sebesar 40oC, karena jika set point kurang dari 40oC mikroba yang menyebabkan pembusukan masih hidup, dan jika suhu lebih dari 40oC maka hanya kulit luar kopi yang akan kering, untuk menjaga kestabilan suhu pada saat proses pengeringan, maka digunakan sebuah kontrol logika fuzzynilai keanggotaan fuzzy yang tepat, kontrol fuzzy terhubung dengan yang terhubung dengan sensor suhu DHT11 dan aktuator servo SG90, setelah melakukan pengujian, kontrol logika fuzzy dengan 5 fungsi keanggotaan merupakan nilai yang tepat, proses pengeringan kopi mendatkan kadar air sebesar 14.1% dengan laju pengeringan sebesar 1.17 %.
Informed-RRT* Using Hybrid Sampling to Finding Fast Final Path Solution
Authors: Fauzi Miftah , Pohan Muhammad Aria Rajasa
Published: November 2021

Informed Rapidly-exploring Random Tree* (Informed-RRT*) merupakan hasil pengembangan dari algoritma Rapidly-exploring Random Tree (RRT) yang dapat menghasilkan solusi jalur yang bersifat asimptotik optimal tetapi waktu komputasi yang dibutuhkan menjadi lebih lama. Pada awalnya algoritma Informed-RRT* masih menggunakan metode random sampling yang mana metode ini akan mengambil sampel acak pada ruang pencarian. Pengambilan sampel acak inilah yang akan membuat waktu komputasi menjadi tidak optimal. Penelitian ini bertujuan untuk merancang algoritma Informed-RRT* menggunakan metode hybrid sampling. Metode hybrid sampling merupakan integrasi dari beberapa metode pengambilan sampel. Pada pengujian ini, performansi metode random sampling akan dibandingkan dengan perfomansi metode hybrid sampling dalam hal waktu komputasi. Pengujian metode hybrid sampling pada algoritma Informed-RRT* ini berbasis simulasi dan dilakukan pada lingkungan narrow, clutter, trap. Hasil yang didapatkan dari pengujian ini adalah penggunaan metode hybrid sampling pada algoritma Informed-RRT* mampu menghasilkan performansi waktu rata- rata komputasi yang lebih cepat 26,4 detik bila dibandingkan dengan metode random sampling pada lingkungan clutter. Pada lingkungan narrow metode hybrid sampling menghasilkan waktu komputasi 24,52 detik lebih cepat bila dibandingkan dengan metode random sampling. Pada lingkungan trap metode hybrid sampling menghasilkan waktu komputasi 5,25 detik lebih cepat dibandingkan dengan metode random sampling. Dari data hasil pengujian, metode hybrid sampling ini dapat menjadi metode pangambilan sampel alternatif untuk digunakan pada algoritma Informed-RRT*
Uso Turístico no Parque Estadual da Costa do Sol (RJ, Brasil): Uma leitura sobre desafios e potencialidades
Authors: Nasri Yasmin Xavier Guimarães , Irving Marta de Azevedo , Oliveira Elizabeth de , Costa Guilherme Borges da
Published: November 2021

A instituição de áreas protegidas representa uma das principais estratégias globais para a conservação da biodiversidade, o equilíbrio climático e a prevenção de futuras crises sanitárias e ecológicas. Nesse contexto, os parques têm relevância central, sobretudo no Brasil, país de dimensões continentais e líder em megadiversidade biológica. Segundo o Sistema Nacional de Unidades de Conservação da Natureza, principal dispositivo legal no país com esse objetivo, a gestão dessas áreas visa, além da própria proteção da natureza, o desenvolvimento de pesquisas e a realização de atividades de turismo ecológico e de educação ambiental. Tendo esses antecedentes como ponto de partida, o objetivo deste artigo é interpretar, criticamente, os desafios relacionados ao uso turístico no Parque Estadual da Costa do Sol (PECS), situado na zona costeira do Estado do Rio de Janeiro. Para tal, a pesquisa qualitativa foi baseada em levantamento bibliográfico e documental, mas também, em observação direta durante as reuniões do Conselho Consultivo e da Câmara Temática de Uso Público do PECS. No período de junho de 2016 a março de 2020, a pesquisa em campo possibilitou a identificação de quinze temas recorrentes com relação ao uso turístico no parque, sistematizados em quatro eixos analíticos associados à complexidade da configuração territorial, ao contexto econômico regional, às dinâmicas sociais e culturais do entorno e, à própria condição de infraestrutura disponível nessa área protegida. A partir dos resultados obtidos é possível afirmar que, embora haja inúmeras potencialidades para tal, o uso turístico no PECS ocorre ainda de maneira desordenada e conflitiva, sendo esse um tema secundário no plano das prioridades de planejamento e gestão da área protegida.
Azerbaycan Türklerinin Atasözlerinde “Yiğit (Kahraman)” Kavramı
Authors: SARPKAYA Seçkin
Published: November 2021

Atasözleri bir toplumun geçmişten günümüze gözlemleriyle hayata dair her olgu ve kavrama dair görüşlerini içeren kısa ve etkin sözlü kültür ürünleridir. Atasözlerinde yaşamın evreleri, değerler, etik unsurlar başta olmak üzere birçok kavram yer alır ve atasözleri, toplumların bunlara yönelik görüşlerinin yapısını ortaya koyar. Türk kültüründe önemli kavramlardan biri yiğitliktir ve yiğitlikle ilgili düşünceler ve ifadeler Türk Dünyası atasözlerinde geniş yere sahiptir. Biz bu makalede Türk kültürü için önemli kavramlardan biri olan kahramanlık kavramını Azerbaycan Türklerinin atasözleri örnekleminde inceledik. Makalede ilk olarak atasözü türünün içerik özellikleri ve kavram kategorileri hakkında kısa bilgi verdik. Devamında Azerbaycan Türklerinin atasözleriyle ilgili kısa bilgi verip Azerbaycan Türklerine ait atasözlerinden hareketle “yiğit (kahraman)” kavramının özelliklerini ele alıp inceledik. Bu incelemede “yiğit” ifadesini içeren belli sayıda atasözünü içerik analiziyle ele aldık. Atasözlerini yiğit ve savaşçılığı, yiğit ve sahip olması gereken özellikler, yiğit ve aile, yiğit ve nam, yiğit ve at başlıklarıyla inceledik. Sonuç olarak Azerbaycan Türklerinin atasözlerinde “yiğit” kavramının özelliklerini ve kahraman kalıbını belirledik.
PENGARUH PUPUK LIMBAH CAIR TAHU TERHADAP PERTUMBUHAN DAN HASIL TANAMAN JAGUNG (Zea mays L.)
Authors: Mardhiana Mardhiana , Murtilaksono Aditya , Simon Heirin
Published: November 2021

ABSTRACTThe corn plant is one of the most cultivated commodities in Tarakan City, North Kalimantan Province. The low nutrient content in Tarakan is a major obstacle in corn cultivation. The application of organic fertilizers adds nutrients to the soil thereby increasing the yield of maize crops. This study aims to determine the effect of organic fertilizers on the growth and yield of maize. The research was conducted at the garden of St. Eugenius (the area around the University of Borneo Tarakan). The study design was a single factor randomized block design with four replications. The treatments were P0 (Control), P1 (basic fertilizer), P2 (300 ml tofu waste), P3 (600 ml tofu waste), P4 (300 ml tofu waste + basic fertilizer) and P5 (600 ml tofu waste + basic fertilizer) . The treatment parameters were plant height, number of leaves, ear weight, ear number, plant wet weight, and plant dry weight. Data analysis using analysis of variance (ANOVA). If there is an effect of treatment, then it is continued by using the DMRT test with alpha level of 5%. The results showed that the treatment of 600 ml of tofu waste + basic fertilizer on all parameters of corn plant observation, namely the parameters of plant height, number of leaves, weight of cobs, number of cobs, plant wet weight and plant dry weight gave the best effect of other treatments. Keywords: Corn, Tofu liquid waste, Organic fertilizer, Growth, Yeild ABSTRAKTanaman jagung merupakan salah satu komoditas yang banyak dibudidayakan di Kota Tarakan Provinsi Kalimantan Utara. Rendahnya kandungan unsur hara yang terdapat di Tarakan menjadi kendala utama dalam budidaya jagung. Pemberian pupuk organik menambah unsur hara pada tanah sehingga meningkatkan hasil panen tanaman jagung. Penelitian ini bertujuan mengetahui pengaruh pupuk organik terhadap pertumbuhan dan hasil tanaman jagung. Penelitian dilakukan di Kebun st.Eugenius (kawasan sekitar Universitas Borneo Tarakan). Rancangan penelitian ini adalah Rancangan Acak Kelompok faktor tunggal dengan empat ulangan. Perlakuannya yaitu P0 (Kontrol), P1 (Pupuk dasar), P2 (300 ml limbah tahu), P3(600 ml limbah tahu), P4 (300 ml limbah tahu + pupuk dasar) dan P5 (600 ml limbah tahu + pupuk dasar). Parameter perlakuan yaitu tinggi tanaman, jumlah daun, berat tongkol, jumlah tongkol, berat basah tanaman, dan berat kering tanaman. Analisis Data menggunakan analisis varian (ANOVA). Jika terdapat pengaruh perlakuan, maka dilanjutkan dengan menggunakan uji DMRT taraf alpha 5%. Hasil penelitian menunjukkan bahwa Perlakuan 600 ml limbah tahu + pupuk dasar pada seluruh parameter pengamatan tanaman jagung yaitu parameter tinggi tanaman, jumlah daun, berat tongkol, jumlah tongkol, berat basah tanaman dan berat kering tanaman memberikan pengaruh yang terbaik dari perlakuan lainnya. Kata Kunci: Jagung, Limbah cair tahu, Pupuk organik, Pertumbuhan, Hasil
Los jóvenes, la enseñanza de la Historia y su mirada frente a los procesos de integración regional
Authors: Cuesta Virginia , Linare Cecilia
Published: November 2021

En este capítulo nos proponemos indagar, por un lado, cuál es el lugar que los jóvenes de los países que integran la muestra le dan a la enseñanza de la historia de América Latina en relación con las historias nacionales, y por otro, cuál es su disposición al integracionismo regional latinoamericano1 a más de veinte años de conformado el Mercosur. Estos temas se vinculan porque nos interesa preguntarnos de qué manera la enseñanza de la historia en Brasil, Argentina, Uruguay, Paraguay y Chile ha contribuido o no a la formación de una mirada favorable o desfavorable al internacionalismo2 latinoamericano. ¿Esta disposición o rechazo al internacionalismo latinoamericano se vincula con el interés de los jóvenes por la historia de una delimitación geográfica o de otra? ¿Se relaciona con las tradiciones de enseñanza de la historia de sus países o con sus políticas curriculares actuales?
Pengembangan Karakter Mandiri Melalui Pembelajaran Tematik pada Kelas III di Madrasah Ibtidaiyah Negeri 5 Jember
Authors: Indrianto Nino , Sya’diyah Halimatus
Published: November 2021

Fungsi pendidikan adalah untuk mengembangkan karakter peserta didik. Oleh karenanya, guru dituntut agar dapat mengembangkan karakter melalui proses pembelajaran diantaranya melalui pembelajaran tematik. Salah satu sikap yang dapat dikembangkan melalui pembelajaran tematik adalah karakter mandiri. Penelitian ini bertujuan untuk mendeskripsikan perencanaan, pelaksanaan serta faktor-faktor yang mempengaruhi pengembangan karakter mandiri melalui pembelajaran tematik pada kelas III di Madrasah Ibtidaiyah Negeri 5 Jember. Penelitian ini menggunakan pendekatan kualitatif dengan jenis fenomenologis. Teknik pengumpulan data menggunakan observasi, wawancara, dan dokumentasi. Hasil penelitian ini adalah: 1) perencanaan pembelajaran tematik dalam pengembangan karakter mandiri di Madrasah Ibtidaiyah Negeri 5 Jember diwujudkan dalam RPP yang disusun secara sitematis dan berbasis karakter dengan memasukkan karakter mandiri pada komponen kompetensi inti, kompetensi dasar, indikator, kegiatan pembelajaran, dan penilaian; 2) pelaksanaan pengembangan karakter mandiri pada pembelajaran tematik dilakukan melalui kegiatan pembelajaran mulai dari kegiatan pendahuluan, inti dan penutup. Namun kegiatan inti lebih dimaksimalkan dengan menggunakan model learning by doing dengan melakukan lima aktivitas belajar yaitu menanya, mengamati, mengumpulkan informasi, mengasosiasi, dan mengkomunikasikan; dan 3) faktor-faktor yang mempengaruhi pengembangan karakter mandiri yaitu lingkungan keluarga, lingkungan sekolah dan lingkungan masyarakat.
Faktor-Faktor Kesulitan Belajar Matematika Siswa Madrasah Ibtidaiyah Da’watul Falah Kecamatan Tegaldlimo Kabupaten Banyuwangi
Authors: Kholil Mohammad , Zulfiani Silvi
Published: November 2021

Salah satu mata pelajaran yang dianggap sulit oleh siswa adalah matematika. Sehingga pelajaran ini kurang diminati siswa. Permasalahan inilah yang menyebabkan banyak siswa mengalami kesulitan belajar matematika. Rumusan masalah dalam penelitian ini yaitu: Kesulitan Belajar Matematika Siswa MI Da’watul Falah Kecamatan Tegaldlimo Kabupaten Banyuwangi Tahun Pelajaran 2018/2019? Sedangkan tujuan penelitian ini adalah untuk mendeskripsikan kesulitan belajar matematika siswa MI Da’watul Falah Kecamatan Tegaldlimo Kabupaten Banyuwangi. Penelitian ini menggunakan pendekatan kualitatif dengan jenis penelitian fenomenologi. Subjek penelitian dalam penelitian ini menggunakan purposive sampling. Teknik pengumpulan data yang digunakan adalah observasi, wawancara, dan dokumentasi. Sedangkan analisis data menggunakan model analisis Miles, Huberman dan Saldana yaitu data Condensation, data Display, serta Conclusion drawing/verivication. Adapun pengecekan keabsahan data yang digunakan adalah triangulasi sumber dan triangulasi teknik. Hasil penelitian ini menunjukkan bahwa kesulitan belajar matematika siswa disebabkan salahnya mindset yang dibangun dari awal oleh siswa, sehingga mereka kesulitan dalam memahami materi yang diajarkan di kelas. Adapun faktor-faktor yang menyebabkan kesulitan belajar terdiri dari faktor internal dan faktor eksternal.
Penanaman Karakter Pada Siswa Melalui Kegiatan Intrakurikuler dan Ekstrakurikuler Di Sekolah Dasar Terpadu Islam
Authors: Baidowi Ach.
Published: November 2021

Character education is an effort to foster and shape student character according to school culture. The research objective was to describe the process of cultivating character in students through school intracurricular and extracurricular activities. The research method with qualitative, data collection with interview, observation, and documentation. The results showed (1) character planting through intracurricular activities with (a) strengthening learning, namely character building in accordance with the theme or material, and (b) spiritual paradigm by inserting Islamic values ??in the learning process. (2) character planting through extracurricular activities with (a) scouts, namely forming leadership characters, being independent, solving problems, and loving nature, (b) leadership, forming leadership characters, responsibility, and making decisions, (c) painting, forming detailed, focused, creative characters , (d) martial art, forming tough, skilled characters, (e) reciting recitation, forming religious, moral, orderly characters, (f) child preachers, forming brave characters, positive thinking, art of communication, influencing others.
Pendidikan karakter merupakan upaya membina dan membentuk karakter siswa sesuai dengan budaya sekolah. Tujuan penelitian untuk mendeskripsikan proses penanaman karakter siswa melalui kegiatan intrakurikuler dan ekstrakurikuler di sekolah. Metode penelitian dengan kualitatif, teknik pengumpulan data dengan wawancara, observasi, dan dokumentasi. Hasil penelitian ini menunjukkan: (1) Penanaman karakter melalui kegiatan intrakurikuler dengan cara (a) Penguatan pembelajaran yaitu pembentukan karakter yang sesuai dengan tema atau materi, dan (b) paradigma spriritual dengan menyisipkan nilai keislaman dalam proses pembelajaran. (2) Penanaman karakter melalui kegiatan ekstrakurikuler, (a) Pramuka yaitu membentuk karakter kepemimpinan, mandiri, memecahkan masalah, dan cinta alam, (b) Kepemimpinan, membentuk karakter kepemimpinan, tanggung jawab, dan membuat keputusan, (c) Melukis, membentuk karakter detail, fokus, kreatif, (d) Pencak silat, membentuk karakter tangguh, terampil, (e) Mengaji, membentuk karakter religious, akhlak, tertib, (f) Pendakwah cilik, membentuk karakter berani, berfikir positif, seni komunikasi, mempengaruhi orang lain.
Analisis Faktor Yang Berhubungan Pada Pasien Rawat Jalan Dalam Mematuhi Protokol Kesehatan Sebagai Upaya Pencegahan Penularan Covid 19 Di Klinik Kosasih Kota Bandar Lampung
Authors: Agustin Rizky Tri , Rahayu Dewi , Listina Febria
Published: November 2021

Berbagai kebijakan dilakukan oleh pemerintah untuk mengendalikan laju kasus Covid 19, salah satunya melalui penerapan protokol kesehatan. Namun, kepatuhan masyarakat terhadap protocol kesehatan masih kurang. Data Badan Pusat Statistik Lampung menunjukkan 55% masyarakat dinyatakan tidak mematuhi protokol kesehatan dan masuk dalam kategori rendah, hasil kegiatan operasi yustisi sampai dengan September 2020 juga menunjukkan hal yang serupa,  ditemukan 232.140 pelanggaran protokol kesehatan se-Lampung. Kurangnya kepatuhan terhadap protocol kesehatan juga terjadi pada lingkungan Klinik Kosasih Bandar Lampung. Penelitian dilakukan untuk menganalisis faktor yang mempengaruhi pasien rawat jalan dalam mematuhi protokol kesehatan covid 19 di Klinik Kosasih.Penelitian ini menggunakan pendekatan kuantitatif menggunakkan metode survei analitik serta desain penelitian cross sectional. Jumlah sampel 207 orang. Penelitian dilakukan pada tujuh titik Klinik Kosasih Kota Bandar Lampung. Pengumpulan data  dilakukan menggunakan kuesioner dan lembar checklist. Analisa data dilakukan dengan cara  analisis univariat, analisis bivariat, dan analisis multivariat.Hasil penelitian menunjukkan bahwa factor yang mempengaruhi kepatuhan pasien rawat jalan terdapat protocol kesehatan meliputi tingkat pengetahuan (OR = 80.729), peran keluarga (OR = 47.532), peran petugas kesehatan  (OR = 21.379), serta ketersediaan sarana dan protokol kesehatan (OR =  11.074). Variabel tingkat pengetahuan (. OR = 99.677) merupakan variabel paling dominan berhubungan dengan kepatuhan pasien rawat jalan dalam mengikuti protocol kesehatan di Klinik Kosasih Kota Bandar Lampung dalam rangka upaya pencegahan penularan Covid-19 adalah variabel tingkat pengetahuan.
Scintillation and dosimetric properties of LiF/CaF2:Dy eutectic composite
Authors: Kawaguchi Noriaki , Kimura Hiromi , Nakauchi Daisuke , Kato Takumi , Yanagida Takayuki
Published: November 2021

Scintillation and dosimetric properties of a LiF/CaF2:Dy eutectic composite have been studied. In the X-ray induced emission spectrum and decay curve, we observed luminescence due to self-trapped exciton of CaF2 and 4f–4f transitions of Dy3+ ions. The LiF/CaF2:Dy eutectic composite showed the light yield of 3000 photons/neutron as a neutron scintillator. The LiF/CaF2:Dy eutectic composite showed the measurable range from 1 mGy to 10 Gy as a thermoluminescence dosimetric material. The LiF/CaF2:Dy eutectic composite can act as a dual functional material for neutron detection and X-ray dosimetry.
Perspectives on functional nitrogen science and plasma-based in situ functionalization
Authors: Ishikawa Kenji
Published: November 2021

Reactive nitrogen species (RNS) generated by controlled electron impacts in conjunction with the use of dinitrogen can react with oxygen and/or hydrogen to generate highly reactive compounds. The related field of functional nitrogen science provides new opportunities for nitrogen utilization based on non-equilibrium plasma processing. This revolutionary technique permits plasma-based nitrogen fixation at the locations at which materials such as dopants and fertilizers are required. This system, based on the in situ generation of RNS at the point of use, is expected to replace conventional processes involving nitrogen cycles employing ammonia and nitric acid. Optimization of this new approach will require nitrogen doping to be tuned by atomic-scale localization of nitrogen. This review discusses the applications of functional nitrogen and the processes by which functionalization in both inorganic materials and living organisms can occur when using RNS.
Asymmetric acoustic retroflection with a non-Hermitian metasurface mirror
Authors: Ju Fangfang , Zou Xiao , Qian Sheng-You , Liu Xiaojun
Published: November 2021

We proposed and designed a non-Hermitian metasurface mirror consisting of two-layers acoustic labyrinthine metamaterials with a full phase control and inherent loss. It yields strongly asymmetric acoustic retroflection (>35 dB) for two opposite incident angles: free retroflection for positive incidence (PI) and strong absorption for negative incidence (NI). It is due to the different diffraction orders related to the period grating for two opposite incident angles: the value of 0 (without multiple reflections) for PI and the value of 2 (with multiple reflections) for NI. Our design may have prospective applications in acoustic sensing, acoustic antennas and noise control.
NUMBER OF PHOSPHORUS DISSOLVING BACTERIA IN THE RHIZOSPHERE OF WINTER WHEAT INOCULATED WITH RHIZOBIUM RADIOBACTER
Authors: Trepach A.O.
Published: November 2021

The paper presents the results of three-year studies aimed to determine the influence of presowing seeds inoculation with Rhizobium radiobacter on the number of phosphorus dissolving bacteria in the rhizosphere of winter wheat. The increase of the number of phosphorus mobilizing microorganisms in root zone of plants at tillering stage under the influence of inoculation was observed.
NITROGEN FIXATION ABILITY IN ROOT ZONE OF PERSPECTIVE NATIONAL VARIETIES OF SPRING TRITICALE
Authors: Shahovnina O.O.
Published: November 2021

Potential activity of nitrogen fixation on washed roots of investigated varieties of spring triticale determined in field experiments has characterized by considerable fluctuations both during single phenophase in different years of research and throughout the vegetative period, that was caused by the influence of environment factors as well as by the existence of variability within the cultivar. The cultivar Oberig kharkovsky possesses the considerable polymorphism by the nitrogen fixation activity index in root zone of plants. Presowing inoculation of triticale seeds with active strain Azospirillum sp. 10 results in the increase of number of plants with higher nitrogen fixation activity on the washed roots.
THE INFECTIOUS DISEASES OF LUPINE YELLOW
Authors: Pirog A.V. , Kolomiets L.P. , Derevyanko S.V.
Published: November 2021

The paper provides the analyses of the wide spread infectious diseases of the lupine yellow. The particularities of the diseases (noninfectious and infectious, caused by viruses, fungi and bacteria) were defined. The patogenesis at plants infection with Bean yellow mosaic virus is followed by the development of typical symptoms which considerablydifferfromsymptomscausedbyotherdiseases.Thatenables the differential diagnostics of this disease and the efficient record of virus infections spreading on the area under lupine crops at phytosanitary surveys, as well as at studying of the influence of different factors on the growth and development of plants infected with the virus.
THE STATE AND PROSPECTS OF THE BIOINDUSTRY DEVELOPMENT IN UKRAINE
Authors: Golovko A.N. , Ushkalov V.A.
Published: November 2021

The paper overviews the questions of the modern condition and prospects of the bioindustry development in Ukraine.
REACTION OF WINTER TRITICALE VARIETIES ON PRESOWING SEED BACTERIZATION
Authors: Bunyak N.N. , Moskalets V.V. , Moskalets T.Z. , Moskalets V.I.
Published: November 2021

Reaction of winter triticale genotypes at presowing seeds inoculation with microbial preparationsAlbobakterin and Diazobakterin was studied. It was established that triticale varieties differently react on used preparations. Seeds bacterization of varieties AD 256, Vivate Nosivsky, Slavetne has promoted the positive changes of its productivity indices at use of Diazobakterin and Albobakterin, varieties DAU 5 and the Jaguar – at use of Diazobakterin, while variety Avgusto – at use of Albobakterin.
YIELD QUALITY OF SOLANUM TUBEROSUM L. UNDER THE INFLUENCE OF MICROBIAL PREPARATIONS AND DEPENDING ON PLANTING TERMS IN WESTERN POLISSYA REGION
Authors: Boroday V. V. , Danilkova T. V. , Koltunov V. A.
Published: November 2021

Application of microbial preparation Planrhiz and fungicide Rydomil Gold MC 68 WG have improved yield, marketability of potatoes and have increased the standard part of tubers. Plants bakterization have promoted increase of potatoes marketability by reducing the number of small, mechanically damaged and sick tubers, with the crop yield higher than the control in 1,5–1,9 times while the number of sick tubers have decreased in 2,4–5,5 times. The combination of microbial agents (Planrhiz + Diazofit + Phosphoenteryn) compared to single application of Planrhiz have revealed no significant difference between the yield and product marketability. As for the planting terms – the 1st planting term in the third decade of April have showed to be the best in West Polissya due to the formation of bigger number of standard part of the tubers.
NITROGEN FIXATION ACTIVITY, EMISSION OF N2O AND CO2 IN PEA AGROCOENOSES UNDER THE INLFUENCE OF FERTILIZERS AND PRE-SOWING SEEDS BACTERIZATION
Authors: Volkogon V.V. , Zhurba M.A.
Published: November 2021

The dynamics of nitrogen fixation, emissions of N2O and CO2 in pea agrocoenoses under the influence of different fertilization systems and pre-sowing seeds inoculation with microbial preparation Rhizohumin were studied in stationary field experiment on leached black soil (short crop rotation potatoes – spring barley – peas – winter wheat). It was observed that symbiotic nitrogen fixation process had become active on the second year aftereffect of 40 t/ha of cattle manure, green manure and use of low (N30P30K30) and medium (N60P60K60) doses of mineral fertilizers. Rhizohumin had significantly increase nitrogen fixation activity in all variants except of the one with manure. Increase of N2O emissions had corresponded to the increasing doses of mineral fertilizers. The use of biological preparation had ensured the reduction of gaseous nitrogen losses due to the initiation of plants development. Carbon dioxide emission values had depended on the type and dose of fertilizers. Rhizohumin had reduced the emission of gaseous carbon compounds in variants with different fertilizer backgrounds due to its extensive use in the formation of additional yield.
INHIBITORY ACTION OF FUNGICIDES ON GERMINATION OF FUNGAL SPORES OF CERCOSPORA BETICOLA SACC. AND ALTERNARIA ALTERNATA KEISSL.
Authors: Vlasiuk O. S.
Published: November 2021

The paper presents the study of the effect of fungicides solutions on the germination of conidia of fungi Cercospora beticola Sacc. and Alternaria alternata (Fr.) Keissl. It was found that inhibition of spore germination with fungicides had significantly depended on the duration of storage and the origin of the fungal isolates. Conidia of C. beticola were less resistant to the action of fungicides than spores of A. alternata. Fungicides Derozal and Alto Super were shown to be the most effective against the germination of spores of Cercospora leaf spot pathogen, while Alto Super — against the Alternaria spot disease.
THE EFFECT OF INTERNAL ENVIRONMENT OF ANIMALS ON PROPERTIES OF PROBIOTIC BACTERIA
Authors: Aheyev V. O.
Published: November 2021

The paper depicts the results of the study of influence of internal environment of animals on preservation of initial biological properties of probiotic bacteria. The increased by 10–15 % antagonistic activity was observed in Bacillus subtilis 44-p strain after its translocation to the laboratory rabbits while for B. subtilis B3 the changes in the morphology of colonies (size and shape) were noticed. Nevertheless, the properties of the studied lactic acid bacteria after exposition to the internal environment of the macroorganism remain unchanged.
INFLUENCE OF FERTILIZERS AND BIOLOGICAL PREPARATION BIOGRAN ON THE VERTICAL MIGRATION OF BIOGENIC ELEMENTS’ COMPOUNDS IN POTATO PLANTS
Authors: Zhurba M. A. , Potapenko L. V.
Published: November 2021

The paper presents the results of lysimetric experiments on potatoes grown on sod-podzolic soils. The positive influence of the microbial preparation Biogran on the restriction of biogenic elements and water-soluble humus removal through the soil profile was observed. The effect of preparation is primarily explained due to the increase of the nutrients removal with the yield.
SUCCESSION OF MICROORGANISMS DURING COMPOSTING OF POULTRY MANURE
Authors: Myagka M. V. , Derkach S. M. , Volkohon V. V. , Lutsenko N. V.
Published: November 2021

The dependence of microorganisms’ development dynamics in composted substrates on the ratio of carbon/nitrogen was showed. Manure composting without C : N ratio optimization ensures the development of most studied groups of microorganisms only in the initial stages of composting. Addition of the chopped straw and peat to the litter in the planned quantities activates transformation of organic matter and increases compost quality. Taking into the account the succession features of microorganisms during composting allows to choose reasonable periods for the introduction of agronomically valuable microorganisms into the substrate.
BACTERIAL TRANSLOCATION OF PROBIOTIC LACTOBACILLI
Authors: Aheyev V. O.
Published: November 2021

The paper presents the results of studying of the dynamics and characteristics of the translocation of two probiotic strains of lactic acid bacteria in the blood and parenchymal organs of animals. The dependence of the bacterial translocation from the bacterial strain and from orally entered dose was established. It was shown that cultural-morphological and physiological-biochemical properties of all isolated from blood cultures of microorganisms have corresponded to the initial properties of bacterial strains introduced to the animals.
NUMBER OF PHOSPHATE-MOBILIZING BACTERIA AND PHOSPHATASE ACTIVITY OF SPRING BARLEY PLANTS RHIZOSPHERIC SOIL UNDER THE ACTION OF FERTILIZERS AND MIKROHUMIN
Authors: Tokmakova L. M. , Trepach A. O. , Lepeha O. P.
Published: November 2021

In the conditions of field stationary experiment on leached black soil the number of bacteria that dissolve organic forms of phosphates was studied, as well as phosphatase activity of spring barley plants rhizospheric soil under the action of fertilizers and microbial agent Mikrohumin. It was found that the studied parameters are positively affected by the introduction of fertilizers into the soil in the amounts not exceeding N60P60K60. Effective is also the first year aftereffect of 40 t/ha of manure. The application of Mikrohumin enables the increase of phosphate-mobilizing bacteria and phosphatase activity of rhizospheric soil in all options of the experiment. When assessing the impact of fertilizers and biological agent interaction on crop performance the perspective of mentioned agricultural backgrounds was shown.
ECONOMIC AND ENERGY EFFICIENCY OF PHOSPHOENTERIN ADMINISTRATION IN GROWING SPRING BARLEY OF STALKER VARIETY
Authors: Baranska M. I. , Halep Y. M. , Chaikovskaya L. A.
Published: November 2021

The results of calculations of economic andenergy efficiency of spring barley of Stalker variety seeds inoculation with bioagent Phosphoenterin on different fertilization backgrounds inthe conditions of southern Steppe of Ukrainewere given. It was found that due to its properties (phosphate-mobilizing and growth-stimulating) Phosphoenteryn provides the highesteconomic and energy efficiency of barley growing in case of medium doses of nitrogen fertilizers (in our case — N53) without the use ofphosphorus ones.
FEATURES OF YOUNG RABBITS INTESTINAL MICROBIOCENOSIS UNDER DIFFERENT FEEDING SYSTEMS
Authors: Pohilko Y. M. , Kravchenko N. O. , Bozhok L. V. , Aheyev V. O. , Dmytruk O. M.
Published: November 2021

The dependence of quantitative and species composition of young rabbits microbocoenosis from feeding system was studied. It was found that in case of concentrate feeding system the number of bifidobacteria and yeast fungi increases. The influence of combined feeding system components on microflora composition of the gastrointestinal tract of young rabbits was studied. It was found that the introduction of a significant proportion of hay to rabbits’ diet leads to the decrease in the number of bifidobacteria and increase in the number of anaerobic bacilli, and in case of the diet based on grain the number of lactic acid bacteria increases and the number of yeast fungi decreases.
INFLUENCE OF DIFFERENT LIGHTING SPECTRA ON GROWTH AND DEVELOPMENT OF IN VITRO VIRUS-FREE POTATO PLANTS
Authors: Reshotko L. M. , Derevianko S. V. , Dmitruk O. O. , Volkova I. V.
Published: November 2021

It was found that the additional lighting affects habіtus of in vitro plants: red light correction increases the growth of potato cultivars such as Shchedrik, Tyras and Suvenir Chernihivskyi, and blue light correction leads to a significant reduction in height of Suvenir Chernihivskyi potato cultivar and to the accelerated formation of stolons in all tested varieties. The chlorophyll content in the leaves of potato plants was increased with additional lighting. It depended both on the light spectra and the reaction of varieties to lighting.
EFFICACY OF TRICHODERMA VIRIDE STRAIN WITH HIGH ANTAGONISTIC AND CELLULOLYTIC ACTIVITY
Authors: А. А. Pavlenko , Ye. P. Kopylov , H. V. Tsekhmister
Published: November 2021

Objective. To study the efficacy of the use of a new strain of Trichoderma viride IMB F-100076 with high antagonistic and cellulolytic activity, in particular its effect on the photosynthetic apparatus and the yield of corn plants. Methods. Study of the effect of T. viride IMB F-100076 on corn94 yield was performed under the conditions of a three-year small-plot field experiment on sodmedium-podzolic soil. The content of chlorophyll a and b in the plants of the experimental variants was determined by spectrophotometry. Methods of mathematical statistics were used in processing the obtained data. Results. Data from a three-year field experiment showed that the application of straw had a negative effect on the yield of corn, which averaged 7.72 t/ha that is 12.3 % less than in the variant without the application of straw (control). Application of the antagonist fungus T. viride IMB F-100076 to the soil simultaneously with straw allowed to obtain an average yield of 9.5 t/ha during three years of study, which is 23 % higher than in the variant with straw. In the control variant (without application of straw and fungal suspension), the yield averaged 8.8 t/ha, which is 14 % higher than in the variant with straw not treated with fungus. It was shown that the content of chlorophylls in corn leaves increases under the influence of T. viride IMB F-100076. For instance, the total content of chlorophyll a and b was 261.04 mg/100 g of leaves, which is 39.0 % higher than in the variant with straw not treatment with a suspension of the fungus, and 15.3 % higher than in the control variant. The obtained results highlight that the treatment of straw with the fungus T. viride IMB F-100076 had a positive effect on the formation of the photosynthetic apparatus of corn plants. Conclusion. Simultaneous application of wheat straw and T. viride IMB F-100076 micromycete, which is characterized by high antagonistic and cellulolytic activity, provides a significant increase in corn yield versus the variant with straw not treated with fungus. The content of chlorophylls a and b in the leaves increases.
THE INFLUENCE OF ACTIVE STRAINS OF NODULE BACTERIA ON EFFICIENCY OF LEGUMINOUS PLANTS
Authors: Nadkernichna E.V. , Kovalevska T.M. , Krutilo D.V. , Gorban V.P. , Vorobej V.S.
Published: November 2021

The results of efficiency studying of new active strains of lupine, peas and soybean nodule bacteria in field and manufacture experiments are given. It is shown, that strains Bradyrhizobium sp. (Lupinus) 5500/4, Rhizobium leguminosarum bv.viceae T2, Bradyrhizobium japonicum КНЮ provide stable increase of leguminous culture crop in comparison with standard strains and they can be used to bacterial preparations manufacture.
THE EFFICIENCY OF BIOLOGICAL PREPARATIONS APPLICATION AT BARLEY PRODUCTION IN RIGHTBANK SARATOV REGION
Authors: Narusheva E.A. , Yurchenko E.S. , Nikiforov V.V.
Published: November 2021

The positive effect of biological preparations Mizorin and BisolbiSunTM on barley productivity was established in field experiments on black soil of Right-Bank Saratov. The best conditions of biological preparations use were created at their combined application with nitrogen-phosphoric fertilizers N45P45.
THE INFLUENCE OF ARBUSCULAR MYCORRHIZAL FUNGI ON ALFALFA RESISTANCE AGAINST POLLUTION WITH HEAVY METALS AND ARSENICUM
Authors: Guralchuk Zh.Z. , Del Val C. , Barea J.M. , Azcon-Aguilar C.
Published: November 2021

The influence of the mycorrhizal infection by G. mosseae (Nicol. et Gerd.) Gerd et Trappe on the growth of Medicago sativa L. plants under different level of soil pollution with heavy metals (Zn, Pb, Cd, Cu) and arsenicum was studied. It was established the strongly increase of the growth and shoot biomass of mycorrhizal plants. The positive effect of mycorrhization on the growth of alfalfa plants was greater in the soils with the higher level of soil pollution with heavy metals and arsenicum.
EFFICIENCY OF MICROGUMIN AT COMBINATION AT COMBINATION SEED TREATMENT OF SUMMER BARLEY WITH RAKSIL
Authors: Pyschur I.M. , Volkogon K.I. , Kosenko L.V.
Published: November 2021

The presowing treatment of barley seeds with the microbial preparation of complex action microgumin promotes sufficient increase of this culture yield and intensification of biological activity in rhizoshere. Combined application of microgumin with the raksil fungicide has not affected biological activity of biological preparation. Applied agricultural technology enhances barley seeds’ germination energy, promotes increase of potential nitrogenase activity on plants’ roots and prevents spreading of root rot diseases. It was established that tebuconasol (raksil reactant) in concentrations 0,01; 0,1; 0,3 g/l of nutrient medium promotes increase of nitrogenase activity of the microgumin bioagent Azospіrіllum brasilense 410.