bluuebunny/crossref_metadata_2025 huggingface dataset:
O “jogo de cintura” como enfrentamento das condições objetivas e subjetivas para a educação inclusiva
Authors: E Silva Lima Marcia Raika
Published: October 2022

A educação especial no âmbito da educação inclusiva apresenta-se em condições desfavoráveis quando se trata das acessibilidades: arquitetônica e de acesso ao currículo. Neste artigo dar-se ênfase à acessibilidade ao currículo, em que se traz o relato de uma professora de História acerca da educação de alunos, público da educação especial-PEE, incluídos em uma escola de ensino médio. Trata-se de recorte de pesquisa de doutorado em educação, defendido em 2016. E, tem como objetivo: analisar as significações de uma professora de escola de ensino médio acerca da inclusão de alunos PEE. O método utilizado foi o materialismo histórico-dialético e optou-se pela entrevista narrativa como os instrumentos e técnicas de pesquisa. Como base analítica teve-se: os Núcleos de Significação. Dialogou-se com autores como Mazzotta (2005), Jannuzzi (2006), Sawaia (2012), Aranha (1995), Lima (2010, 2016) que teorizam discussões acerca da educação especial e inclusiva. O resultado evidenciou que a participante exalta a criatividade, que expressa como “jogo de cintura”, para driblar as contingências imperativas da sociedade, que desconsidera as singularidades dos alunos PEE, e os meios de acesso e a permanência escolar. Conclui-se que a professora, mediada pela vivência com esses alunos incluídos, pôde transformar seu fazer pedagógico diante das condições objetivas que encontra para incluí-los.
O que dizem os/as estudantes do ensino secundário de Portugal em relação ao uso das tecnologias digitais
Authors: Junior Luiz Martins , Martins Rosa Elisabete Militz Wypyczynski , Dias Julice
Published: October 2022

As tecnologias digitais têm influenciado a cultura, a economia e a Educação, bem como a vida escolar e cotidiana dos/as estudantes. Com isso, a escola se viu diante de um desafio: regular o uso dessas tecnologias sem afastar suas potencialidades para fins pedagógicos. Sendo assim, o presente artigo é parte de uma pesquisa de doutorado defendida em 2020, e tem como objetivo analisar o uso das tecnologias digitais pelos/as estudantes no cotidiano e nas aulas de Geografia, considerando frequência, aplicabilidade e finalidades dessa utilização. A pesquisa está ancorada numa metodologia qualitativa na modalidade colaborativa com aplicação de questionário para vinte e cinco estudantes do ensino secundário de Portugal. O estudo permite afirmar que os desafios e possibilidades encontradas quanto ao uso das tecnologias digitais pelos/as estudantes são frequentes em seu cotidiano, para diferentes finalidades, seja de lazer ou fins educativos. Da análise também desdobraram informações referentes à agilidade, facilidade e ao domínio por parte dos/as estudantes ao fazer o uso de diferentes tipos e formas de tecnologias digitais.
Do reconhecimento da Libras como língua à compreensão do processo de criação de novos sinais na área da tecnologia
Authors: Andreis-Witkoski Sílvia , Maestri Rita de Cássia , Monteiro Tânia Lúcia , Kovalhuk Gabriel , Marquezi Luana , Guzzo Adriana de Mello , Oliveira Giovana Maria de , Righetto Leonardo Guzzo
Published: October 2022

No Brasil, o reconhecimento da Língua Brasileira de Sinais (Libras) como língua oficial das pessoas surdas ocorreu somente em 2002, por meio da Lei nº 10.436. Posteriormente, esta foi regulamentada pelo Decreto nº 5.626/2005, que estabeleceu inúmeras prerrogativas para esse alunado, inclusive prevendo o direito ao intérprete da Libras nos diferentes níveis de ensino do sistema público e privado, sem ônus financeiro. Ao considerar-se o quanto a conquista dos direitos supracitados é recente, entende-se por que muitas áreas do conhecimento ainda apresentam lacunas de sinais para designar diferentes termos, na medida em que, antes da legislação referida, a presença desse alunado nas universidades era pouco significativa. Desta feita, uma vez que somente os surdos podem criar sinais, tais vácuos de sinais são proporcionais à ausência desses sujeitos nessas instituições. A fim de contribuir para sanar esse déficit, têm surgido iniciativas para a criação deles, assim como de coleta dos já existentes. O objetivo é compartilhá-los por todo o território nacional, em diferentes plataformas digitais. Dentre essas, os autores surdos do presente artigo estão coletando e criando sinais da área de tecnologia, os quais são disponibilizados no site “Sinais na Libras: Área de Tecnologia”. No presente artigo, além de resgatarem-se os aspectos históricos que explicam as lacunas de sinais ainda existentes, são abordadas as singularidades da criação de sinais pelo grupo de surdos referido, buscando elucidar o processo criativo que envolve a concepção de sinais que expressem seus respectivos conceitos.
Characterization of Errors in Retinopathy of Prematurity Diagnosis by Ophthalmologists-in-Training in the United States and Canada
Authors: Al-Khaled Tala , Patel Samir N. , Valikodath Nita G. , Jonas Karyn E. , Ostmo Susan , Allozi Rawan , Hallak Joelle , Campbell J. Peter , Chiang Michael F. , Chan R.V. Paul
Published: October 2022

Purpose:

To identify the prominent factors that lead to misdiagnosis of retinopathy of prematurity (ROP) by ophthalmologists-in-training in the United States and Canada.

Methods:

This prospective cohort study included 32 ophthalmologists-in-training at six ophthalmology training programs in the United States and Canada. Twenty web-based cases of ROP using wide-field retinal images were presented, and ophthalmologists-in-training were asked to diagnose plus disease, zone, stage, and category for each eye. Responses were compared to a consensus reference standard diagnosis for accuracy, which was established by combining the clinical diagnosis and the image-based diagnosis by multiple experts. The types of diagnostic errors that occurred were analyzed with descriptive and chi-squared analysis. Main outcome measures were frequency of types (category, zone, stage, plus disease) of diagnostic errors; association of errors in zone, stage, and plus disease diagnosis with incorrectly identified category; and performance of ophthalmologists-in-training across postgraduate years.

Results:

Category of ROP was misdiagnosed at a rate of 48%. Errors in classification of plus disease were most commonly associated with misdiagnosis of treatment-requiring (plus error rate = 16% when treatment-requiring was correctly diagnosed vs 81% when underdiagnosed as type 2 or pre-plus; mean difference: 64.3; 95% CI: 51.9 to 76.7;
P
< .001) and type 2 or pre-plus (plus error rate = 35% when type 2 or pre-plus was correctly diagnosed vs 76% when overdiagnosed as treatment-requiring; mean difference: 41.0; 95% CI: 28.4 to 53.5;
P
< .001) disease. The diagnostic error rate of postgraduate year (PGY)-2 trainees was significantly higher than PGY-3 trainees (PGY-2 category error rate = 61% vs PGY-3 = 35%; mean difference, 25.4; 95% CI: 17.7 to 33.0;
P
< .001).

Conclusions:

Ophthalmologists-in-training in the United States and Canada misdiagnosed ROP nearly half of the time, with incorrect identification of plus disease as a leading cause. Integration of structured learning for ROP in residency education may improve diagnostic competency.

[
J Pediatr Ophthalmol Strabismus
. 2023;60(5):337–343.]
Inclusion results for the class of fuzzy $ \alpha $-convex functions
Authors: Shah Shujaat Ali , Ali Ekram Elsayed , Maitlo Asghar Ali , Abdeljawad Thabet , Albalahi Abeer M.
Published: October 2022

The notion of a fuzzy subset is used to introduce certain subclasses of analytic functions. Mainly, this article presents several inclusion results and integral preserving properties. Also, certain applications of the analytic functions in terms of fuzzy structure will be discussed.
A hyperchaos generated from Rabinovich system
Authors: Li Junhong , Cui Ning
Published: October 2022

In this paper, we present a 4D hyperchaotic Rabinovich system which obtained by adding a linear controller to 3D Rabinovich system. Based on theoretical analysis and numerical simulations, the rich dynamical phenomena such as boundedness, dissipativity and invariance, equilibria and their stability, chaos and hyperchaos are studied. In addition, the Hopf bifurcation at the zero equilibrium point of the 4D Rabinovich system is investigated. The numerical simulations, including phase diagrams, Lyapunov exponent spectrum, bifurcations, power spectrum and Poincaré maps, are carried out in order to analyze and verify the complex phenomena of the 4D Rabinovich system.
Low-Temperature Direct Bonding of 3D-IC Packages and Power IC Modules Using Ag Nanotwinned Thin Films
Authors: Chuang Tung-Han , Wu Po-Ching , Lai Yu-Chang , Lee Pei-Ing
Published: October 2022

Ag has the lowest stacking fault energy of all metals, which allows twin formation to occur more easily. The (111)-preferred orientation Ag nanotwinned films is fabricated by either sputtering or evaporation method exhibit columnar Ag grains grown vertically on Si substrates. Ag nanotwinned films have a (111)-preferred orientation with a density about 98% and diffusivity that is 2 to 5 orders of magnitude higher than those of (100) and (110) surfaces. Low temperature direct bonding with (111)-oriented Ag nanotwins films is proposed to fulfil the requirements for wafer-on-wafer (WoW), chip-on-wafer (CoW), and chip-on-wafer-on-substrate (CoWoS) advanced 3D-IC packaging, with the process temperature drastically reduced to 100°C. Such an innovative bonding method also provides a promising solution for die attachment of Si chips with DBC-ceramic substrates for power module packaging.
Simplified Approach to Verification of Numerical Models for Deformation and Fracture Analysis of Structural Composite Subjected to High-Velocity Impact
Authors: Olivenko Nikita A. , Kudryavtsev Oleg A. , Ignatova Anastasia V.
Published: October 2022

Deformation and fracture analysis of the composite elements and structures under high-velocity impact is still associated with many problems. These problems are related not only to the complexity of taking into account the composite layered orthotropic structure and various failure scenarios but also to the problems of instrumented high-velocity impact tests to verify the calculation results. Different requirements for accuracy and numerical efficiency are imposed on the models and their predictive ability depending on the design stage. At the initial design stages, the model should allow one to estimate the energy absorption of the composite structure adequately. At later stages, the size of the damaged area and the fracture pattern also should be predicted with high accuracy. This article describes a simplified approach to the verification of deformation and fracture models of structural composites under high-velocity impact based on low-velocity impact test data. The model with the found parameters makes it possible to predict with satisfactory accuracy the energy absorption of the composite material.
Inhomogeneous Beam of Circular Cross-Section with Concentric Lengthwise Cracks: A Fracture Analysis with Considering Viscoplastic Behaviour
Authors: Rizov Victor Iliev
Published: October 2022

In this paper, a lengthwise fracture analysis of a viscoplastic inhomogeneous cantilever beam of circular cross-section acted upon by a torsion moment is presented. The beam is with an arbitrary number of concentric lengthwise cracks. The time-dependent mechanical behaviour of the beam is treated by a viscoplastic model representing a series of units which are combinations of springs, dashpots and frictional sliders. Due to the sliders, the model units start to deform one after another with increasing of the external load. Constitutive laws of the viscoplastic model are obtained and applied to treat the beam mechanical behaviour when deriving time-dependent strain energy release rates for the lengthwise cracks.
Experimental Investigation for the Performance of the Solar Air Dryer with Vortex Generator
Authors: Mushatet Khudheyer S. , Bader Nabaa Mohammed
Published: October 2022

Experimental simulations were conducted to analyze the thermal properties of a solar air dryer embedded with a delta-winglet vortex generator (DWVG). The present inquiry goal is to enhance the thermal performance of the solar air dryer. The delta-winglets were placed at the bottom absorber duct surface. Eight pairs of DWVG were considered for relative height (e/H) ratio from 0.2 to 0.6, an angle of attack (ß) was preserved at 60°, and the pitch-ratio (p/e) was equal to 10. This experimental investigation was performed for 0.022kg/s (MFR) and solar irradiance varied from (300 to 920) W/m2. The winglet vortex generators were set in a common flow-down configuration. The impact of (DWVG) on thermal efficiency and useful thermal energy was discussed. The thermal efficiency (η) and useful thermal energy (Qu) at 0.6 (e/H) appear improved up to about 6.5% and 9.4% respectively, higher than a smooth solar air dryer. The (DWVG) affects outlet air temperature, resulting in a considerable increase in the heat transfer convective rate.
An Approach in Analyzing Longitudinal Fracture of Inhomogeneous Beams with Using Generalized Viscoplastic Models
Authors: Rizov Victor Iliev
Published: October 2022

This paper introduces a generalized viscoplastic model and describes its application in treating the longitudinal fracture of inhomogeneous beam structures. The model is a combination of an arbitrary number of parallel units. Each unit is obtained by two springs and a dashpot. Besides, a frictional slider is placed parallel with one of the springs in each unit of the model in order to treat the plastic strains. The time-dependent constitutive law of the model obtained by considering strains, stresses and equilibrium of the model components is used in deriving solution of the strain energy release rate for the longitudinal crack in the viscoplastic beam.
Consumer Preference and Price Behavior Analysis for Selected Rice Varieties in Sri Lanka
Authors: Kuruppu I. V.
Published: October 2022

Price of agricultural commodities acts as a significant driving force in any economy. In many developing countries price of agricultural commodities creates food insecurity hence, this is more prominent in countries that depend on agriculture. Agriculture has been identified as the backbone of the Sri Lanka and rice is considered as the staple food in the country. Therefore, continuous analysis and monitoring of rice price is a must to identify potential market behavior for rice price and to take necessary actions to maintain stability. In light of that, this study aims to analyze the price behavior of most common rice varieties (Samba, Nadu, Raw White, and Raw Red) in Sri Lanka, linking it with consumer preference. Both nominal market price (NMP) and real market price (RMP) was analyzed. NMP of all rice types had increased continuously. However, RMP from 2008 to 2013 had gradually decreased. The average price of Samba always retained LKR 15.00/kg higher than Nadu, LKR 18.00/kg higher that Raw Red and LKR 21.00/kg higher than Raw White. Further, NMP of Samba had increased by eight per cent, Nadu by nine per cent, Raw White by 11 per cent and Raw Red by 10 per cent annually. Time series plots were derived for each rice types separately. Price increment or decrement of different rice varieties demonstrated a strong positive relationship with each other. Also, 60 percent of Sri Lankans are preferred to consume Samba, Nadu and Raw White. Raw Red consumption is mainly concentrated in the Southern Province of Sri Lanka. Few large scale millers scattered within the major paddy producing areas exercise an oligopolistic behavior and, as a result sudden variations in prices were observed in off-seasons.
Use of Geographically Weighted Regression to Determine Natural Rubber Productivity and Their Driving Forces: A Case Study in the Kalutara District of Sri Lanka
Authors: Sankalpa J. K. S. , Wijesuriya W. , Karunaratne S. , Ishani P. G. N.
Published: October 2022

The goal of this study was to analyze the productivity variation in smallholder rubber lands in Kalutara district located in the wet zone of Sri Lanka and spatial relationship of key drivers to the productivity variation. Low productivity has been a major challenge in rubber plantations in the country in recent years. In this study spatial modelling tools available in geographic information science were used to explore the spatial variability of the rubber productivity and explored the key drivers of it in spatial context. Geostatistical kriging analysis is a simple type of prediction method which includes the cross validation of prediction and error terms in forecasting techniques. The productivity of smallholder rubber lands in Kalutara district varied from 777 to 1463 kg/ha/year, while the highest average productivity was recorded in the Divisional Secretariat (DS) divisions; Palindanuwara, Beruwala and Kalutara. Low productivity was recorded in Matugama and in a few areas in Ingiriya and Bandaragama divisions. Local variation of driving forces behind the average productivity was explored using Geographically Weighted Regression (GWR) method. GWR explored the spatial variability of the relationship between productivity and fertilizer usage, weeding, soil conservation, number of tappable trees and age of trees under tapping. All the variables were found to present significant spatial variabilities. Apart from generating global significant value, the model resulted local variation of each parameter estimates with respect to the projected coordinates of the area. Emerge of sign change of local parameters observed in some areas cannot be observed globally. It is necessary to understand the significance level of local coefficient subject to the multicolinearity and spatial auto correlation.
Why Coping Cost is An Underestimate of Willingness to Pay? Some Theoretical Explanations Based on Forest Water Link
Authors: Bansal G. , Das S.
Published: October 2022

One of the revealed preference approaches of finding peoples’ willingness to pay to provide a resource conveniently, for an instance, piped water supply to a locality, is through coping cost estimation, where coping costs are costs incurred in different types of coping mechanism to adapt to a resource stress and live in harmony with the limited resource. However, empirical research shows that willingness to pay elicited through surveys is usually higher than the coping costs incurred for the same resource constraint, though the extent of diversion depends on many socio-economic and spatial locational factors. The present study tries to explain the differences theoretically taking the water scarcity in remote hilly areas as an example.
List of Reviewers - Vol, 17(1) 2022
Authors: Editor-in-chief .
Published: October 2022

N/A
Determinants of Operational e-HRM Adoption Behavior of the Firms in Sri Lanka: An Integrated Model
Authors: Galhena B. L.
Published: October 2022

Compared to firms in developed economies, e-HRM adoption of firms in emerging economies indicates relatively a slow adoption rate, as they experience specific challenges pertaining to e-HRM implementation. This study explores the determinants of operational e-HRM adoption behaviors of the firm in emerging economies, Sri Lanka. To realize the objective, this study develops an integrated model to explain operational e-HRM adoption behavior of firms incorporating innovation, individual, organizational, and environmental contextual factors. The research model was built by integrating Diffusion of innovation theory (DIT) and Theory of Planned Behavior (TPB). Data were collected through self-administered questionnaire employing three types of data collection tools: mail survey, personal interviews, e-mail survey. Data were collected from 212 firms. PLS-SEM used to test the research model due to its complexity, non-normal data distribution, and sample size requirements. Findings revealed that all the innovation context variables excluding trialability determine the intention of operational e-HRM adoption. Subjective norm of profession was a significant driver of explaining the intention of operational e-HRM adoption. Competition which was specified under environmental context also found empirical support. When it comes to organizational context financial resource, top management support found as significant driver of predicting extent of operational e-HRM adoption. Moreover, as TPB proposed, this study found that intention to adopt operational e-HRM adoption is positively related to the extent of operational e-HRM adoption. From a theoretical perspective, this study extends DIT by including organizational and environmental contextual factors as potential predictors of firms’ operational e-HRM adoption. Moreover, TPB is extended by including innovation contextual factors that determine operational e-HRM adoption behaviors of firms.
Transcriptomic Profiling Identifies CD8+ T Cells in the Brain of Aged and Alzheimer’s Disease Transgenic Mice as Tissue-Resident Memory T Cells
Authors: Altendorfer Barbara , Unger Michael Stefan , Poupardin Rodolphe , Hoog Anna , Asslaber Daniela , Gratz Iris Karina , Mrowetz Heike , Benedetti Ariane , de Sousa Diana Marisa Bessa , Greil Richard , Egle Alexander , Gate David , Wyss-Coray Tony , Aigner Ludwig
Published: October 2022

Peripheral immune cell infiltration into the brain is a prominent feature in aging and various neurodegenerative diseases such as Alzheimer’s disease (AD). As AD progresses, CD8+ T cells infiltrate into the brain parenchyma, where they tightly associate with neurons and microglia. The functional properties of CD8+ T cells in the brain are largely unknown. To gain further insights into the putative functions of CD8+ T cells in the brain, we explored and compared the transcriptomic profile of CD8+ T cells isolated from the brain and blood of transgenic AD (APPswe/PSEN1dE9, line 85 [APP-PS1]) and age-matched wild-type (WT) mice. Brain CD8+ T cells of APP-PS1 and WT animals had similar transcriptomic profiles and substantially differed from blood circulating CD8+ T cells. The gene signature of brain CD8+ T cells identified them as tissue-resident memory (Trm) T cells. Gene Ontology enrichment and Kyoto Encyclopedia of Genes and Genomes pathway analysis on the significantly upregulated genes revealed overrepresentation of biological processes involved in IFN-β signaling and the response to viral infections. Furthermore, brain CD8+ T cells of APP-PS1 and aged WT mice showed similar differentially regulated genes as brain Trm CD8+ T cells in mouse models with acute virus infection, chronic parasite infection, and tumor growth. In conclusion, our profiling of brain CD8+ T cells suggests that in AD, these cells exhibit similar adaptive immune responses as in other inflammatory diseases of the CNS, potentially opening the door for immunotherapy in AD.
Tumor Environment Promotes Lnc57Rik-Mediated Suppressive Function of Myeloid-Derived Suppressor Cells
Authors: Wang Ya , Gao Yunhuan , Zhang Chunze , Yue Jianmei , Wang Rong , Liu Hang , Yang Xiaorong , Zhang Yuan , Yang Rongcun
Published: October 2022

Myeloid-derived suppressor cells (MDSCs) are pathologically activated neutrophils and monocytes with potent immunosuppressive activity that regulate immune responses in the tumor microenvironment. We identified a novel long noncoding RNA (lncRNA), named as lnc57Rik, in the MDSCs that controls their immunosuppressive functions. Lnc57Rik was induced in in vitro and in vivo inflammatory settings and upregulated the genes related to MDSC-mediated immunosuppression, including Arg-1, NOS2, NOX2, and COX2. Furthermore, Lnc57Rik can not only bind with the C/EBPβ isoform liver-enriched activator protein to activate C/EBPβ but also with the methyltransferase WD repeat-containing protein 5 that enables the enrichment of histone H3 trimethylated lysine 4 marks on the promoter regions of Arg-1, NOS2, NOX2, and COX2, eventually resulting in their transcriptional activation. Furthermore, the conserved human lnc57Rik has a similar function as murine lnc57Rik. Taken together, upregulation of lnc57Rik in the tumor microenvironment promotes the immunosuppressive function of MDSCs.
Acceptability of the Kangaroo Mother Care at the University Hospital of Treichville in Côte d’Ivoire
Authors: Doukouré Daouda , Kourouma Kadidiatou Raissa , Yacé Marie Laurette Agbré , Cissé Lassina , Méazieu Chantière Some , Manouan Mathilde N'Guetta , Lasme Ester Annick , Bayo Syntyche , Aké-Tano Sassor Odile Purifine , Kouakou Julie Sackou , Kouakou Virginie Konan
Published: October 2022

Background. Kangaroo Mother Care (KMC) is a low-tech, high-impact intervention for preterm and low-birth-weight newborns. In 2019, Côte d’Ivoire opened its first KMC unit. We wanted to determine KMC’s acceptability in Côte d’Ivoire after a year.Methods.  This qualitative study used semi-structured interviews in September 2020 at the Teaching Hospital of Treichville’s first KMC unit. Mothers of preterm and low birth weight babies who received KMC were studied. Deductive (TFA-driven) framework analysis was performed. Coded using Nvivo 12.Results. KMC was acceptable overall. Mothers knew KMC’s goal and benefits, including self-confidence and breastfeeding benefits. Most women reported that the method was easy to implement and were confident in implementing KMC at the unit or in the household, even though some of them found KMC not aligned with their cultural values. Some mothers, especially housewives and self-employed, highlighted the benefits of KMC, but they must have given up.Conclusions. Our study highlighted the need to increase KMC awareness, advocacy, education, and training for pregnant women and the community to reduce preterm and low birth weight infant mortality and morbidity.
Effect of the COVID-19 pandemic on the financial revenues of public hospitals with a care centre: case of the Yaoundé Central Hospital
Authors: Kouanfack Charles , Fouakeng Suzie Estelle Fomekong , Nguekam Michel Foalem , Whegang Solange Youdom , Chefor Alain Djam , Dzudie Anastase , Ateudjieu Jérôme , Sobngwi Eugène , Fouda Pierre Joseph
Published: October 2022

Background: In 2020, the world was confronted with COVID-19, which caused a socio-economic panic in several sectors. The use of hospitals has been affected, with an impact on their financial performance. The objective of this study was to assess the effect of the pandemic on the financial performance of a hospital with a care center.Methodology: This was a cross-sectional study targeting the Yaoundé Central Hospital over two periods : before the pandemic (March to August 2019) and during the pandemic (March to August 2020). Based on the administrative accounts, revenues from the main sources of financial inflows were recorded and compared before and during the pandemic.Results: From March to August 2019, overall revenue was 1,131,525,099 FCFA and from March to August 2020, it was 762,770,714 FCFA, representing a drop of 32.6%. Medical imaging showed a drop of 14% corresponding to a loss of 96,500,052 FCFA. The laboratory showed a 21% decrease corresponding to a loss of 80,691,347 FCFA. Hospital admissions fell by 21%, corresponding to a loss of 62,124,675 FCFA. Consultations fell by 10%, corresponding to a loss of 49,265,835 FCFA.Conclusion: The COVID-19 pandemic had a negative effect on the financial revenues of the Yaoundé Central Hospital.
Caraway extract alleviates atopic dermatitis by regulating oxidative stress, suppressing Th2 cells, and upregulating Th1 cells in mice
Authors: Khajepour Fardin , Zangouyee Mohammad Reza , Khosravimashizi Arezu , Afgar Ali , Abdollahi Vahideh , Dabiri Shahriar , Nosratabadi Reza
Published: October 2022

Objective:

To explore the anti-inflammatory and antioxidant effects of caraway on atopic dermatitis (AD) in mice.

Methods:

AD was induced in two stages, including sensitization and challenge with the application of 2,4 dinitrochlorobenzene 2% and 0.2%, respectively. Clinical symptoms and histological analysis of the skin were assessed. The effects of caraway on oxidant/antioxidant parameters as well as Th1- and Th2-related cytokines were also evaluated.

Results:

Caraway reduced the severity of dermatitis in AD-induced mice, as evidenced by significant inhibition of Th2-related cytokines (IL-4 and IL-13) and increased Th1-related cytokine (IFN-γ). Additionally, treatment with caraway significantly increased superoxide dismutase and catalase activity and decreased the malondialdehyde level in the serum of AD mice. Furthermore, caraway inhibited the differentiation of Th2 cells while favoring Th1 cell differentiation in the spleen via regulating their master transcription factors GATA3 and T-bet.

Conclusions:

Caraway could improve AD autoimmune responses and could be considered a potential candidate to treat AD disease.
In vitro anti-melanoma effect of polyphenolic compounds
Authors: Sioud Fairouz , Maatouk Mouna , Bzeouich Imen Mokdad , Ghedira Leila Chekir , Kilani-Jaziri Soumaya
Published: October 2022

Objective:

To evaluate the effects of phenolic acids (caffeic, ferulic, and coumaric acids) and flavones (luteolin and apigenin) on the proliferation and melanogenesis in murine melanoma B16-F10 cells.

Methods:

Cell proliferation was determined after 24 and 48 hours of incubation using MTT assay. The effects of these tested compounds on cell cycle progression were analyzed by flow cytometry. Moreover, the melanin content and tyrosinase activity were measured spectrophotometrically at 475 nm.

Results:

Luteolin and apigenin exhibited significant anti-proliferative activity against B16-F10 cells, while caffeic, ferulic, and coumaric acids induced slight inhibition after 24 and 48 hours of incubation. The tested compounds disturbed cell cycle progression of B16-F10, by a subsequent decrease in G1 and arrested cycle progression in either G1/S or G2/M phase. Furthermore, apigenin provoked an increase in melanin content of B16-F10 cells. In contrast, luteolin, caffeic, ferulic and coumaric acids induced a decrease in melanin content of B16-F10 cells by inhibiting tyrosinase activity.

Conclusions:

These active polyphenols may be used as skin whitening agents or natural tanning agents to treat skin pigmentation disorders.
A review on Moroccan thyme species
Authors: Elbouny Hamza , Ouahzizi Ibrahim , Bakali Abdelmonaim H. , Sellam Khalid , Alem Chakib
Published: October 2022

Morocco is characterized by a great richness and biodiversity in Thymus plants. This genus is represented in this country by 22 thyme species and subspecies, 13 of which are endemic. The present review aims to study the ethnopharmacological, phytochemical, and biological aspects of these thyme species. To carry out this study, the research studies on Moroccan Thymus plants were reviewed in the scientific literature. We found that the species of this genus have widespread uses and applications in Moroccan folk medicine. These plants possess potent pharmacological and biological properties. Moreover, the extracts and volatile oils of thyme plants are rich in a wide variety of phenolic and terpene compounds. These bioactive compounds exert countless biological and pharmacological properties. The present review concludes that there is an important biodiversity in thyme species in Morocco. These species are endowed with several biological properties and ethnopharmacological uses. However, several species of this genus are still not exploited and need more botanical, phytochemical, and pharmacological investigations.
Percolation probability and critical exponents for site percolation on the UIPT
Authors: Ménard Laurent
Published: October 2022

We derive three critical exponents for Bernoulli site percolation on the uniform infinite planar triangulation (UIPT). First, we compute explicitly the probability that the root cluster is infinite. As a consequence, we show that the off-critical exponent for site percolation on the UIPT is
$\beta = 1/2$
. Then we establish an integral formula for the generating function of the number of vertices in the root cluster. We use this formula to prove that, at criticality, the probability that the root cluster has at least n vertices decays like
$n^{-1/7}$
. Finally, we also derive an expression for the law of the perimeter of the root cluster and use it to establish that, at criticality, the probability that the perimeter of the root cluster is equal to n decays like
$n^{-4/3}$
. Among these three exponents, only the last one was previously known. Our main tools are the so-called gasket decomposition of percolation clusters, generic properties of random Boltzmann maps, and analytic combinatorics.
Utopia e heterotopia: Análise da normatização e das resistências dos corpos e espaços
Authors: Brito Marcelo , Meireles Ildenilson , Simões Mota Iuri
Published: October 2022

O artigo tem como objetivo debater sobre o corpo enquanto um espaço heterotópico, tomando por base a noção definida por Foucault, O Corpo, as heterotopias. Nesse sentido, propomos compreender como os corpos dissidentes da cisnormatividade podem ser entendidos como um espaço heterotópico na medida em que se mostram como um instrumento de resistência às formas de normalização e normatização de si mesmos e do espaço físico. O significado de corpo em nossa análise aponta para um espaço de luta, de disputa de sentidos entre os sujeitos e de embate de diferentes relações de poder que atravessam os indivíduos e suas vivências. Propomos pensar as pessoas trans a partir da ideia do corpo como uma heterotopia, tanto pelo seu caráter de resistência aos processos de normatizações, como pelo processo de apropriação que essas pessoas fazem da sua identidade, constituindo-se como sujeitos dos seus desejos e subjetividades. Os corpos dissidentes são considerados como um espaço heterotópico na medida em que estão gravados na constituição do mesmo uma série de processos de significações e construções socioculturais, mas ao mesmo tempo esse corpo, enquanto espaço heterotópico, resiste e subverte o processo, as imposições binárias e o discurso cisnormativo, criando em si mesmos um espaço heterotópico.
"We had time for ourselves" – Israeli Homeschooling Graduates Talk About Their Learning and Activities in Homeschooling
Authors: Edri Avishag , Court Deborah
Published: October 2022

This study focuses on the homeschooling experiences of Israeli homeschool graduates. The phenomenon of homeschooling has been evolving in recent years as more and more parents choose to educate their children at home. In the world, and also in Israel, many studies have been conducted on homeschooling, but in Israel no research has been conducted on homeschooling graduates. Homeschooling is a relatively new phenomenon in Israel and only in recent years has a significant group of graduates been formed. This qualitative, phenomenological study focused on Israeli homeschooling graduates who had reached the age of eighteen and studied most of their elementary and high school years at home. Using semi-structured, in-depth interviews with 15 homeschooling graduates, the study sought to understand how homeschooling graduates spent their time in childhood and adolescence, the educational approach used in their homes, and their perceptions of their learning experiences. The findings uniquely detail homeschooling from the perspective of homeschooling graduates and interpret them in light of intrinsic motivation theories. The parents’ and homeschool graduates’ educational approaches and attitudes fostered children’s intrinsic motivation to learn.
PERBANDINGAN SUPERVISI MODEL PROCTOR DAN MODEL REFLEKTIF DALAM MENINGKATKAN MUTU PELAYANAN KEPERAWATAN DI RUANGAN RAWAT COVID-19
Authors: Sidauruk Orenta , Tri Kurniati  , Luknis Sabri
Published: October 2022

Supervisi keperawatan merupakan upaya untuk membangun keahlian, peningkatan kemampuan staf keperawatan dengan memberikan dorongan, bimbingan serta pendampingan. Situasi pandemic Covid-19 menimbulkan banyak tantangan dalam memberikan pelayanan keperawatan, namun tetap menuntut pelayanan keperawatan yang bermutu. Penelitian ini bertujuan untuk mengetahui perbandingan supervisi model proctor dan model reflektif terhadap peningkatan mutu pelayanan keperawatan di ruang perawatan Covid-19. Penelitian merupakan penelitian kuantitatif menggunakan desain Cross Sectional dengan jumlah sample 76 responden yang terbagi pada dua kelompok sample yaitu 39 responden pada kelompok supervisi model proctor dan 37 responden pada kelompok supervisi model reflektif. Uji statistic yang digunakan adalah uji chi square dan uji t independen. Berdasarkan analisa data bivariat, diperoleh adanya pengaruh antara pelaksanaan supervisi model proctor maupun pelaksanaan supervisi model reflektif terhadap peningkatan mutu pelayanan keperawatan di ruang perawatan Covid-19 Rumah Sakit Umum Pusat Persahabatan Jakarta. Pada uji t independen ditemukan tidak ada perbedaan yang signifikan rata-rata mutu pelayanan keperawatan pada kedua kelompok sample. Terdapat pengaruh antara pelaksanaan supervisi model proctor dan model reflektif terhadap peningkatan mutu pelayanan keperawatan di ruang perawatan Covid-19 Rumah Sakit Umum Pusat Persahabatan Jakarta, namun tidak ada perbedaan yang signifikan rata-rata mutu pelayanan keperawatan antara pelaksanaan supervisi model proctor dengan pelaksanaan supervisi model reflektif.
Innovation is the Way Forward: The Impact of Organisational Culture on Innovation in the United Arab Emirates (UAE)
Authors: Islam Shk. Imran
Published: October 2022

This paper aims to investigate the impact of organization culture on innovation using the United Arab Emirates (UAE). A quantitative approach was used for the study collecting data from 557 individuals working across the seven states of UAE in different organisations. The data was analysed using SmartPLS where partial least squares – structural equation modeling were used to test the relationship between organisation culture and innovation. The results show that, the unique working environment in UAE where there is a vast mix of cultures from all over the world making it difficult to establish a steady working culture, organisation culture still has a positive impact on innovation. The finding suggests that organisations and the government should take advantage of this situation and drive innovation using the correct approach.
Forecasting Potato Prices: Application of ARIMA Model
Authors: Badal Prakash Singh
Published: October 2022

Price fluctuations in potatoes (Solanum tuberosum L.) concern consumers, farmers, and policymakers, and its accurate price prediction is important for all the stakeholders. In India, out of a total of 5.34 million ha of land under vegetables, potato occupies nearly 20.8 per cent of area. India produces 12.3 per cent of world potato production (around 45.34 million tons) and is next only to China. The major potato-producing states are highly concentrated in the Indo-gangetic plains of the country. Uttar Pradesh, West Bengal and Bihar account for 32.4, 26.9 and 14.6 per cent of national production of potato. The present study was designed to forecast the prices of potato in these three major potato-producing states of the country. Autoregressive Integrated Moving Average forecasting models - ARIMA (1,0,1) for Varanasi market, ARIMA (2,0,1) for Kolkata market, and the ARIMA (3,0,1) for Patna market were applied. The performance of the ARIMA models produced reliable forecast of prices of potatoes for all three major producing states.
Economic Security of the Enterprise Within the Conditions of Digital Transformation
Authors: Samoilenko Yuliia
Published: October 2022

In the context of the digital economy development, the priority component of the economic security of an enterprise is changing from material to digital, constituting an independent element of enterprise security. The relevance of the present research is driven by the need to solve the issue of modernizing the economic security of the enterprise taking into account the new risks and opportunities of digitalization. The purpose of the academic paper lies in identifying the features of preventing internal and external negative influences (threats) in order to guarantee the effective and stable functioning and dynamic social development of the enterprise in the context of digitalization. The research methods are as follows: general scientific research methods, in particular, logical analysis, theoretical substantiation, methods of induction and deduction, formalization and generalization, statistical observation. Results. It has been proposed to introduce the concept of “digital security of the enterprise” for replacing the concept of “information component of economic security” in order to bring the terminology in line with new economic realities. The implementation of the “black box” model has made it possible to identify the latest risks and threats to the economic security of an enterprise within the conditions of the digitalization that differs from the existing ones. The assessment of enterprises’ digital security of the European Union member states has revealed that the digital security level does not depend on the size of the country, however, it is influenced by the institutional environment (in particular, digital development tools in the EU) and the size of enterprises. Also, within the research framework, an assessment of the digital security level of enterprises in the context of digitalization has been proposed. In order to characterize enterprises by the level of digital security, a calculation procedure using the coefficient method has been proposed.
"Market Integration and Seasonal Prices of Paddy: An Economic Analysis"
Authors: G.D. Rede,
Published: October 2022

To frame an inclusive agricultural policy, analysis of price and market arrivals overtime is essential. Variations in market arrivals mainly leads to price instability. Such study is beneficial for farmers in demand to select the appropriate time to sell their farm produce to get best economic profits. On this sight the present study was undertaken to examine the seasonality and market integration of Paddy in Gadchiroli District of Maharashtra. The secondary data were collected for a period of 15 years from 2006 to 2020. Data were analysed using simple tabular analytical tools and functional analysis approaches. The data showed a highest seasonal indices of arrivals in the month of January and lowest in month of August in Chamorshi and Gadchiroli markets, respectively. In terms of paddy price, the highest and lowest seasonal indices of prices were seen in the months of July and March in Chamorshi market where as in the months of September and March in Gadchiroli market. Contradictory relationship between arrival and prices was witnessed in the designated markets. The degree of integration was found strong and positive of prices. Transparency in price signal among both markets resulted in strong integration. For better operations of well integrated markets, there should be provision of more investments and for the less integrated markets, need of adoption of online marketing system and awareness creation is needed to eliminate the malpractices in agricultural markets. These results recommend market integration and competition rather than collusions of markets in the study area.
Tooth Root Formation
Authors: Goldberg Michel
Published: October 2022

The formation of the tooth crown implies dentin and pulp construction (including mantle dentin, odontoblasts, Höhl cells, and vascular, axons and pulp cells). The root formation involves acellular and cellular cementum, peripheral and central dentins. Vascular cells and nerves are located in the central part of the root, whereas the superficial layer (Hopewell-Smith and Tomes granular layers) are located at the periphery. In the central part of the pulp, fibroblasts and immunocompetent cells are identified as T-lymphocytes, B-lymphocytes, dendritic cells, NK cells. In human deciduous teeth, HLA-DR+, CD68+, and factor XIIIa are present, whereas T and B-lymphocytes form clusters. The Hertwig’s Epithelial Enamel Epithelium (HERS’s) is formed by two layers. The HERS’s cells dissociate, and cells, taking origin from the dental follicular sac and from the papilla, migrates. The OEE becomes periodontal ligament cells whereas the IEE becomes cementoblasts. The interconversion of epithelial cells into mesenchymal cells seems to be a crucial event in tooth root formation. Tooth eruption is associated to root lengthening. The temporary tooth is gradually destroyed (root cementoclasts), whereas the permanent coronal part of the tooth erupts and acquire it final shape and position.
Visual Outcomes of Secondary Lens Implants in Children with Different Etiologies
Authors: Netralaya Drashti
Published: October 2022

Aim: This study investigated visual outcomes and factors that impact vision in children receiving secondary Intraocular Lens (IOL) implants.

Methods: Children who had traumatic or congenital cataracts and underwent secondary lens implantation for aphakia at Drashti Netralaya between 2000 and 2019 were retrospectively examined. We included all the eyes with secondary implants for aphakia correction with placement either in the bag or sulcus or through scleral fixation. We obtained data from electronic medical records and analyzed using SPSS 22 through descriptive analysis, cross tabulation and t test.

We evaluated visual outcomes among different patients.

Results: Our cohort consisted of 84 eyes (mean age: 7.88 ± 6.07 years). Of the 84 eyes, 24 (28.6%) and 60 (71.4%) were female and male patients, respectively and 32 (38.1%) had traumatic cataract. We observed significant improvements in vision following lens implantation (p=0.000). Those with nontraumatic cataracts exhibited better outcomes that did the traumatic cataract group (p=0.004). Corneal opacity caused comorbidities in the traumatic group (14/52, 14.29%). Visual outcomes significantly improved in young patients and were not affected by other variables.

Conclusion: Secondary lens implantation significantly improved vision in aphakic children. Young patients and those with nontraumatic cataracts demonstrated more favorable visual outcomes.
BLAMING THE VICTIM PADA KASUS PELECEHAN SEKSUAL DI PERGURUAN TINGGI DALAM PERSPEKTIF HUKUM PIDANA
Authors: Kinandana Kayuan Putu Chandra , Andika Pratama I Putu
Published: October 2022

Fenomena blaming the victim pada kasus pelecehan seksual di lingkup perguruan tinggi masih banyak terjadi. Korban justru dianggap sebagai pemicu atau penyebab terjadinya pelecehan seksual oleh pelaku kejahatan, khususnya di perguruan tinggi. Penelitian ini menggunakan tipe penulisan Doctrinal Research dengan menggunakan bahan hukum primer, sekunder dan tersier. Teknik pengumpulan bahan hukum dilakukan dengan sistem kartu dan menggunakan pendekatan perundang-undangan pendekatan fakta dan pendekatan analisis konseptual. Hasil dari penelitian ini adalah dengan hadirnya Permendikbud Ristek No. 30 Tahun 2021 dan peraturan perundang-undangan lain yang mengatur mengenai korban pelecehan seksual, diharapkan dapat meminimalisir kasus pelecehan seksual dan korban tidak akan takut lagi untuk melaporkan kasus yang terjadi. Selain itu juga hadirnya UU No. 31 Tahun 2014 diharapkan melindungi para korban pelecehan seksual agar tidak mengalami intervensi dan diskriminasi (blaming the victim) oleh pihak-pihak tertentu.