bluuebunny/crossref_metadata_2025 huggingface dataset:
Defining the Potential Targets for Biological Activity of Isoegomaketone Based on Network Pharmacology and Molecular Docking Methods
Authors: Zhang Juzhao , Wang Ruo , Qin Yuxuan , Feng Chengling
Published: December 2022

Isoegomaketone is a water-soluble natural ketone compound that is commonly present in Rabdosia angustifolia and Perilla frutescens. At present, it is known that isoegomaketone has a wide range of pharmacological activity, but there has been no thorough investigation of its potential targets. As a result, we examined the potential targets of isoegomaketone using the network pharmacology approach. In our study, the TCM Database@Taiwan was utilized to search for the chemical formula. The pharmacological characteristics of isoegomaketone were then evaluated in silico using the Swiss Absorption, Distribution, Metabolism, and Excretion (Swiss ADME) and Deep Learning–Acute Oral Toxicity (DL-AOT) methods, and the potential isoegomaketone target genes were identified using a literature study. Additionally, using the clusterProfiler R package 3.8.1, the Gene Ontology (GO) enrichment analysis and the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis of target genes were performed. In order to obtain the protein interaction network, we simultaneously submitted the targets to the STRING database. After this, we performed molecular docking with respect to targets and isoegomaketone. Finally, we created visual networks of protein–protein interactions (PPI) and examined these networks. Our results showed that isoegomaketone had good drug-likeness, bioavailability, medicinal chemistry friendliness, and acceptable toxicity. Subsequently, through the literature analysis, 48 target genes were selected. The bioinformatics analysis and network analysis found that these target genes were closely related to the biological processes of isoegomaketone, such as atherosclerotic formation, inflammation, tumor formation, cytotoxicity, bacterial infection, virus infection, and parasite infection. These findings show that isoegomaketone may interact with a wide range of proteins and biochemical processes to form a systematic pharmacological network, which has good value for the creation and use of drugs.
Monoamine Oxidase (MAO) Is Expressed at the Level of Mitral Valve with Severe Regurgitation in Hypertrophic Obstructive Cardiomyopathy: A Case Report
Authors: Lascu Ana , Șoșdean Raluca , Ionică Loredana Nicoleta , Pescariu Alexandru S. , Petrescu Lucian , Ionac Adina , Luca Constantin T. , Sturza Adrian , Feier Horea B.
Published: December 2022

Hypertrophic obstructive cardiomyopathy (HOCM) is one of the most common hereditary heart diseases. The severely hypertrophied interventricular septum combined with the systolic anterior movement (SAM) of the mitral valve (MV) frequently cause a significant pressure gradient in the left ventricular outflow tract associated with varying degrees of mitral regurgitation (MR). We present the case of a 64-year-old female patient who was diagnosed with HOCM two years ago and was admitted to the Institute of Cardiovascular Disease with exertion dyspnea and fatigue. Transthoracic echocardiography revealed concentric, asymmetrical left ventricular hypertrophy, an elongated anterior mitral leaflet (AML) and a significant SAM causing severe regurgitation, with indication for valvular replacement Monoamine oxidase (MAO), a mitochondrial enzyme, with 2 isoforms, MAO-A and B, has emerged as an important source of reactive oxygen species (ROS) in the cardiovascular system, but literature data on its expression in valvular tissue is scarce. Therefore, we assessed MAO-A and B gene (qPCR) and protein (immune fluorescence) expression as well as ROS production (spectrophotometry and confocal microscopy) and in the explanted MV harvested during replacement surgery. MAO expression and ROS production (assessed by both methods) were further augmented following ex vivo incubation with angiotensin II, an effect that was reversed in the presence of either MAO-A (clorgyline) or B (selegiline) inhibitor, respectively. In conclusion, MAO isoforms are expressed at the level of severely impaired mitral valve in the setting of HOCM and can be induced in conditions that mimic the activation of renin-angiotensin-aldosterone system. The observation that the enzyme can be modulated by MAO inhibitors warrants further investigation in a patient cohort.
In Situ Ageing with the Platform Preheating of AlSi10Mg Alloy Manufactured by Laser Powder-Bed Fusion Process
Authors: Chambrin Nicolas , Dalverny Olivier , Cloue Jean-Marc , Brucelle Olivier , Alexis Joel
Published: December 2022

AlSi10Mg alloy is mainly produced by laser fusion on a powder bed. It offers a good compromise between easy processing and good mechanical properties. These properties depend on the manufacturing parameters, including the preheating temperature, as this alloy hardens by precipitation. This study explored the effect of preheating to 170 °C on the mechanical properties and microstructure of this alloy as a function of the manufacturing time. The mechanical properties were characterized by tensile, hardness and impact strength tests as a function of the sample height. An anisotropic behavior was confirmed: the horizontal orientation showed higher deformation and fracture energies. In addition, a gradient of properties appeared as a function of the distance from the platform; the closer the sample was to the platform, the higher its fracture energy and the lower its hardness. The hardness values followed the same evolution as a function of the distance to the platform as that of the hardness curve after ageing post-treatment. It was therefore shown that the preheating of the platform generated in situ ageing with respect to the manufacturing height: a hardness peak was obtained at a certain distance from the plateau (40 mm—10 h of remaining manufacturing time) and over-aging near the plateau was induced by long exposure times at 170 °C.
Electron Beam-Induced Reduction of Cuprite
Authors: Siudzinska Anna , Gorantla Sandeep M. , Serafinczuk Jaroslaw , Kudrawiec Robert , Hommel Detlef , Bachmatiuk Alicja
Published: December 2022

Cu-based materials are used in various industries, such as electronics, power generation, and catalysis. In particular, monolayered cuprous oxide (Cu2O) has potential applications in solar cells owing to its favorable electronic and magnetic properties. Atomically thin Cu2O samples derived from bulk cuprite were characterized by high-resolution transmission electron microscopy (HRTEM). Two voltages, 80 kV and 300 kV, were explored for in situ observations of the samples. The optimum electron beam parameters (300 kV, low-current beam) were used to prevent beam damage. The growth of novel crystal structures, identified as Cu, was observed in the samples exposed to isopropanol (IPA) and high temperatures. It is proposed that the exposure of the copper (I) oxide samples to IPA and temperature causes material nucleation, whereas the consequent exposure via e-beams generated from the electron beam promotes the growth of the nanosized Cu crystals.
Potentiostatic Dealloying Fabrication and Electrochemical Actuation Performance of Bulk Nanoporous Palladium
Authors: Tan Fuquan , Yu Bin , Bai Qingguo , Zhang Zhonghua
Published: December 2022

Metallic actuators increasingly exhibit superiority over conventional actuators (such as piezoelectric ceramics) via low energy consumption and large strain amplitude. Large strain amplitude and high strain energy density (or work density) are required for an actuator with excellent comprehensive performance. Herein, we fabricated bulk nanoporous Pd (np-Pd) with a dense nanoporous structure by two-step potentiostatic dealloying of as-annealed Ni–Pd alloy with chemical corrosion resistance, and investigated the dealloying behaviors as well as electrochemical actuation performance. A visible current density oscillation occurred during dealloying, which is related to formation/dissolution of the passivating film. Additionally, since the dense and continuous ligaments establish a good network connectivity for large strain response, the np-Pd achieves a strain amplitude of up to 3.74% and high strain energy density, which stands out among many actuator materials (e.g., np-AuPt, np-Ni, and np-AlNiCu). Our study provides a useful guidance for fabricating metallic actuators with excellent comprehensive performance.
Interfacial Polarization-Dominated Dielectric Loss in SnO2@rGO Electromagnetic Wave Absorbers
Authors: Shen Hao , Shi Xinyu , Wang Zhen , Zou Pengfei , Hou Zhaoyang , Xu Chunlong , Zhang Limin , Wu Hongjing
Published: December 2022

Interfacial polarization is generally a major cause of dielectric loss, but its exact contribution to the electromagnetic wave (EMW) absorption capacity of absorbers remains to be elucidated. In this work, SnO2@rGO composite (S2) with tight interfaces formed by chemical bonds and SnO2/rGO mixture (S3) were synthesized by a simple chemical route followed by further calcined in argon, respectively. Compared with pure SnO2 (S1) and S3, S2 exhibits much better EMW-dissipation ability, with a smaller minimum reflection loss (RLmin) value of −20.5 dB at a matched thickness of 5 mm and a larger effective absorption bandwidth (fe) value of 5.8 GHz (from 11 GHz to 16.8 GHz) at 3.2 mm. By comprehensively comparing the defects, dipoles, and interfaces in S2 and S3, it is concluded that the excellent EMW absorption capacity of S2 is mainly caused by strong dielectric loss dominated by interfacial polarization as well as suitable impedance matching. This study provides an insight into the exact contribution of interfacial polarization to the EMW-dissipation ability of absorbers, showing that the EMW absorption of graphene-based composites can be effectively promoted by constructing well-connected interfaces between graphene and absorbers.
Chemical Modifications Influence the Number of siRNA Molecules Adsorbed on Gold Nanoparticles and the Efficiency of Downregulation of a Target Protein
Authors: Epanchintseva Anna V. , Poletaeva Julia E. , Dome Anton S. , Dovydenko Ilya S. , Pyshnaya Inna A. , Ryabchikova Elena I.
Published: December 2022

Small interfering RNAs (siRNAs) are a powerful tool for specific suppression of protein synthesis in the cell, and this determines the attractiveness of siRNAs as a drug. Low resistance of siRNA to nucleases and inability to enter into target cells are the most crucial issues in developing siRNA-based therapy. To face this challenge, we designed multilayer nanoconstruct (MLNC) with AuNP core bearing chemically modified siRNAs. We applied chemical modifications 2′-OMe and 2′-F substitutions as well as their combinations with phosphoryl guanidine group in the internucleotide phosphate. The effect of modification on the efficiency of siRNA loading into nanocarriers was examined. The introduction of the internucleotide modifications into at least one of the strands raised the efficiency of siRNA adsorption on the surface of gold core. We also tested the stability of modified siRNA adsorbed on gold core in the presence of serum. Based on loading efficiency and stability, MLNCs with the most siRNA effective cargo were selected, and they showed an increase in biological activity compared to control MLNCs. Our study demonstrated the effect of chemical modifications of siRNA on its binding to the AuNP-based carrier, which directly affects the efficiency of target protein expression inhibition.
Ag-Decorated Iron Oxides-Silica Magnetic Nanocomposites with Antimicrobial and Photocatalytic Activity
Authors: Muşat Viorica , Crintea (Căpăţână) Lenuța , Anghel Elena-Maria , Stănică Nicolae , Atkinson Irina , Culiţă Daniela Cristina , Baroiu Liliana , Țigău Nicolae , Cantaragiu Ceoromila Alina , Botezatu (Dediu) Andreea-Veronica , Carp Oana
Published: December 2022

Nanotechnology offers unlimited possibilities for creating effective hybrid materials, which combine functional performance in environment depollution and antimicrobial defense with a lack of toxicity, biocompatibility, biodegradability, and natural availability. This paper presents the silver effect on photocatalytic and antibacterial activities of double-coated iron oxide nanoparticles (NPs), Fe3O4@SiO2/ZnO-Ag. The structural, morphological, and textural information of the, core–shell iron oxides-based superparamagnetic nanoparticles (IOMNPs) decorated with 5% Ag by ultrasound-assisted synthesis were evaluated by scanning electron microscopy with energy dispersive spectroscopy (SEM-EDX), X-ray diffraction, Raman spectroscopy, and Brunauer–Emmett–Teller physisorption measurements. Although two synthesis temperatures of 95 and 80 °C were used for the co-precipitated iron oxide cores, the XRD patterns revealed the formation of a single magnetite, Fe3O4, phase. The sorption–photocatalytic activities under dark and UV irradiation encountered a maximum removal efficiency of the MB (90.47%) for the Fe3O4@SiO2/ZnO-Ag sample with iron oxide core obtained at 80 °C. The rate constant for the second-order kinetics was 0.0711 min−1 for 2 h, and the correlation coefficient R2 closed to unity. Two samples with Ag-decorated hybrid SiO2/ZnO shell and hierarchically interconnected porous structure with large surface area (328.8 and 342.5 m2g−1) exhibited the best disk diffusion antimicrobial activity against four microorganisms, especially gram-positive Staphylococcus aureus.
Nanoscale Refractive Index Sensors Based on Fano Resonance Phenomena
Authors: Ren Yifeng , Wang Qiang , Shen Lifang , Liu Feng , Cui Yang , Zhu Chuanhui , Chen Zhanbo , Huang Biyi , Yan Shubin
Published: December 2022

In this paper, a new refractive index sensor based on Fano resonance is introduced. It is mainly composed of two parts: a metal–insulator–metal as a base waveguide and an annular resonant cavity with a double notch and a double convex circle as a coupling structure. The sensing characteristics of the design are investigated via finite element calculations. The influence of the remaining structure parameters on the system’s sensing performance and the relationship between the wavelength corresponding to the Fano trough and the refractive index are also investigated. Furthermore, the structure is applied to refractive index sensors, resulting in a type with a sensitivity of 2740 nm/RIU and a figure of merit of 52.69.
Procyanidins from Cranberry Press Residues—Extraction Optimization, Purification and Characterization
Authors: Klavins Linards , Perkons Ingus , Mezulis Marcis , Viksna Arturs , Klavins Maris
Published: December 2022

Procyanidins are a polyphenolic group that can be found in a variety of foods such as chocolate, tea, cranberries and others. Type A procyanidins can be found in a handful of sources and one of the richest sources are American cranberries. These compounds possess antioxidative, anticancer and anti-inflammatory activities and are most widely used as prevention for urinary tract infections. Cranberries are utilized for jam and juice production, and the latter produces industrial food waste press residues. Press residues contain free and bound procyanidins which can be extracted for use as nutraceuticals. In this study, the extraction of cranberry press residues has been optimized using RSM and the resulting extracts have been purified and fractionated. The obtained procyanidin fractions have been investigated for their antioxidative potential and analyzed using LC-ESI-FTICR-HRMS to determine individual procyanidins. The optimization showed that the optimal extraction can be conducted using acetone in a concentration of 53% without the addition of an acidifying agent. Strong correlation was observed for procyanidin contents and their antioxidative activity using DPPH, ABTS and FRAP methods. The purified fractions contained 78 individual (65 Type A) procyanidins with the degree of polymerization of up to 9.
Quercus ilex Phyllosphere Microbiome Environmental-Driven Structure and Composition Shifts in a Mediterranean Contex
Authors: Postiglione Alessia , Prigioniero Antonello , Zuzolo Daniela , Tartaglia Maria , Scarano Pierpaolo , Maisto Maria , Ranauda Maria Antonietta , Sciarrillo Rosaria , Thijs Sofie , Vangronsveld Jaco , Guarino Carmine
Published: December 2022

The intra- and interdomain phyllosphere microbiome features of Quercus ilex L. in a Mediterranean context is reported. We hypothesized that the main driver of the phyllosphere microbiome might be the season and that atmospheric pollutants might have a co-effect. Hence, we investigated the composition of epiphytic bacteria and fungi of leaves sampled in urban and natural areas (in Southern Italy) in summer and winter, using microscopy and metagenomic analysis. To assess possible co-effects on the composition of the phyllosphere microbiome, concentrations of particulate matter and polycyclic aromatic hydrocarbons (PAHs) were determined from sampled leaves. We found that environmental factors had a significative influence on the phyllosphere biodiversity, altering the taxa relative abundances. Ascomycota and Firmicutes were higher in summer and in urban areas, whereas a significant increase in Proteobacteria was observed in the winter season, with higher abundance in natural areas. Network analysis suggested that OTUs belonging to Acidobacteria, Cytophagia, unkn. Firmicutes(p), Actinobacteria are keystone of the Q. ilex phyllosphere microbiome. In addition, 83 genes coding for 5 enzymes involved in PAH degradation pathways were identified. Given that the phyllosphere microbiome can be considered an extension of the ecosystem services offered by trees, our results can be exploited in the framework of Next-Generation Biomonitoring.
Cell-Type-Specific Length and Cytosolic pH Response of Superficial Cells of Arabidopsis Root to Chronic Salinity
Authors: Ageyeva Maria , Veselov Alexander , Vodeneev Vladimir , Brilkina Anna
Published: December 2022

Soil salinity negatively affects the growth, development and yield of plants. Acidification of the cytosol in cells of glycophytes was reported under salinity, while various types of plant cells can have a specific reaction under the same conditions. Transgenic Arabidopsis plants expressing the pH sensor Pt-GFP in the cytosol were used in this work for determination of morphometric changes and cytosolic pH changes in the superficial cells of Arabidopsis roots under chronic salinity in vitro. We did not find changes in the length of the root cap cells, while there was a decrease in the length of the differentiation zone under 50, 75 mM NaCl and the size of the epidermal cells of the differentiation zone under 75 mM NaCl. The most significant changes of cytosolic pH to chronic salinity was noted in columella (decrease by 1 pH unit at 75 mM NaCl) and epidermal cells of the differentiation zone (decrease by 0.6 and 0.4 pH units at 50 and 75 mM NaCl, respectively). In developed lateral root cap cells, acidification of cytosol by 0.4 units occurred only under 75 mM NaCl in the medium. In poorly differentiated lateral cells of the root cap, there were no changes in pH under chronic salinity.
Origin of the Rare Hybrid Genus ×Trisetokoeleria Tzvelev (Poaceae) According to Molecular Phylogenetic Data
Authors: Gnutikov Alexander A. , Nosov Nikolai N. , Koroleva Tatiana M. , Punina Elizaveta O. , Probatova Nina S. , Shneyer Victoria S. , Rodionov Alexander V.
Published: December 2022

In our article, we analyzed new data on the origin of the hybrid genus ×Trisetokoeleria. According to the morphological criteria ×T. jurtzevii is a hybrid between Koeleria asiatica s. l. and Trisetum spicatum, ×T. taimyrica, and originated from Koeleria asiatica s. l. and Trisetum subalpestre, ×T. gorodkowii, a hybrid between Koeleria asiatica and Trisetum ruprechtianum. Later ×T. taimyrica was transferred to Koeleria. Parental taxa are prone to active hybridization themselves, thus, new methods of next-generation sequencing (NGS) were needed to clarify the relationships of these genera. For NGS we used the fragment 18S rDNA (part)–ITS1–5.8S rDNA (totally 441 accessions). We analyzed ITS1–5.8S rDNA–ITS2 region, trnL–trnF and trnK–rps16 from eight samples of the five species, using the Sanger method: ×Trisetokoeleria jurtzevii, ×T. taimyrica, Koeleria asiatica, Sibirotrisetum sibiricum (=Trisetum sibiricum), and Trisetum spicatum. We also studied the pollen fertility of ×Trisetokoeleria and its possible progenitors. Our data partly contradicted previous assumptions, based on morphological grounds, and showed us a picture of developed introgression within and between Koeleria and Trisetum. ×T. jurtzevii, a totally sterile hybrid formed rather recently. We can suppose that ×T. jurtzevii is a hybrid between K. asiatica and some Trisetum s. str. Species, but not T. spicatum. ×T. gorodkowii, a hybrid in the stage of primary stabilization; it has one unique ribotype related to T. spicatum s. l. The second parental species is unrelated to Trisetum ruprechtianum. ×T. taimyrica and is a stabilized hybrid species; it shares major ribotypes with the T. spicatum/T. wrangelense group and has a minor fraction of rDNA related to genus Deyeuxia s. l.
Racial and Ethnic Inequalities, Health Disparities and Racism in Times of COVID-19 Pandemic Populism in the EU: Unveiling Anti-Migrant Attitudes, Precarious Living Conditions and Barriers to Integration in Greece
Authors: Fouskas Theodoros , Koulierakis George , Mine Fotini-Maria , Theofilopoulos Athanasios , Konstantopoulou Sofia , Ortega-de-Mora Fabiola , Georgiadis Dimitrios , Pantazi Georgia
Published: December 2022

The COVID-19 pandemic has had a significant impact particularly on the most vulnerable populations, including immigrants, asylum seekers and refugees in the EU. The article depicts the results of the comparative research project “Local Alliance for Integration (LION/GSRI/University of West Attica/81018): Migrant and Refugee integration into local societies in times of the COVID-19 pandemic in Spain and Greece” implementing a qualitative methodology. This article analyses via 32 in-depth interviews the experiences of immigrants, asylum seekers and refugees in Greece, the increased barriers towards integration due to racial and ethnic inequalities, precarity and health disparities during this period which function as a means of perpetuating exclusion in five sectors: (a) formal employment, (b) healthcare, (c) formal education and language training, (d) housing and social care/protection, and (e) intercultural coexistence as well as the new rise of a hostile rhetoric and anti-migrant attitudes under a COVID-19 pandemic populism. The unravelling of the narratives revealed perceptions and practices of inequality and uncertainty as well as of hope. The socioeconomic impact of the pandemic on immigrants, asylum seekers and refugees, similarities and differences that occurred and evidence of the ongoing obstacles they encountered during the pandemic are presented. Policy and practice implications include the implementation of prevention measures by the institutions that are tasked with the responsibility to remove hindrances, address unequal treatment, racial/ethnic and social inequalities and raise awareness on multiple ways in which the COVID-19 pandemic has intensified vulnerability.
The Effects of Chinese Consumers’ Brand Green Stereotypes on Purchasing Intention toward Upcycled Clothing
Authors: Pang Chen , Zhou Jie , Ji Xiaofen
Published: December 2022

Due to environmental concerns, an increasing number of Chinese consumers have begun to resist fast fashion, promoting cheap and lower quality materials with a short lifetime. A shift from a linear economic model to a circular fashion has become an urgent issue for the industry. To examine how brand stereotype affects consumers’ purchasing intention toward upcycled fabric clothing, this study adopted a grounded theory approach to develop the dimensions of brand stereotypes, including product, manufacturing process, service, and communication. Furthermore, a theoretical model was constructed incorporating brand stereotypes, brand green trust, fashion consciousness, and green consciousness. Results from structural equation model analysis indicated that (1) each dimension of brand stereotypes had a significantly positive impact on behavior intention, and especially product and service image have the most influence; (2) brand green trust mediated the relationship between brand stereotypes and buying intention, and (3) green consciousness positively moderated the relationship between brand stereotype and trust, whereas brand warmth in communication and trust was moderated negatively by fashion consciousness. The findings offer implications for the implementation of the green branding strategy, brand positioning, and cultivating consumers’ green awareness to improve market acceptance of upcycled fabric clothing.
Scattering in Algebraic Approach to Quantum Theory—Associative Algebras
Authors: Schwarz Albert
Published: December 2022

The definitions of scattering matrix and inclusive scattering matrix in the framework of formulation of quantum field theory in terms of associative algebras with involution are presented. The scattering matrix is expressed in terms of Green functions on shell (LSZ formula), and the inclusive scattering matrix is expressed in terms of generalized Green functions on shell. The expression for inclusive scattering matrix can be used also for quasi-particles (for elementary excitations of any translation-invariant stationary state, for example, for elementary excitations of equilibrium state). An interesting novelty is the consideration of associative algebras over real numbers.
Assessment and Analysis of Citizens’ Perceptions of Visual Corridors in Tehran City
Authors: Zabetian Targhi Elham , Razi Vida
Published: December 2022

Today, in many cities, urban facades are typically forming according to the high-level codes, while citizens’ expectations and preferences are different from them. According to the studies conducted theory, using a conceptualization technique, related dimensions are assessed. For details, each facade is divided into three parts: ground floor, body, and coping. The individuals’ perceptions are investigated using electronic questionnaires and with panoramic photos. To assess vision while moving, studies are carried out at the sites (6 selected streets in Tehran) using semi-structured interviews as well as photographing the preferred scenes and the worst scenes (VEP method). According to the analyses, the main result of this research shows that overall perception was greater than in partial. The order in urban facades will not necessarily be perceived by the alignment of the openings and the creation of a uniform skyline, or restrictions on the color and type of facade materials. This is the same damage mentioned in the critique of the upper-level design codes in the present study. Therefore, it is better to consider only a limited number of various items in building facades, that people can perceive, fixed and controlled, and leave the rest to the owners and designers. In this way, the private rights of the owners and the art of the designers can be respected by observing the facade as a common area between private privacy and public privacy.
The Mechanism of Important Components in Canine Fecal Microbiota Transplantation
Authors: Li Kerong , Yang Jie , Zhou Xiaoxiao , Wang Huan , Ren Yuxin , Huang Yunchuan , Liu Haifeng , Zhong Zhijun , Peng Guangneng , Zheng Chengli , Zhou Ziyao
Published: December 2022

Fecal microbiota transplantation (FMT) is a potential treatment for many intestinal diseases. In dogs, FMT has been shown to have positive regulation effects in treating Clostridioides difficile infection (CDI), inflammatory bowel disease (IBD), canine parvovirus (CPV) enteritis, acute diarrhea (AD), and acute hemorrhagic diarrhea syndrome (AHDS). FMT involves transplanting the functional components of a donor’s feces into the gastrointestinal tract of the recipient. The effective components of FMT not only include commensal bacteria, but also include viruses, fungi, bacterial metabolites, and immunoglobulin A (IgA) from the donor feces. By affecting microbiota and regulating host immunity, these components can help the recipient to restore their microbial community, improve their intestinal barrier, and induce anti-inflammation in their intestines, thereby affecting the development of diseases. In addition to the above components, mucin proteins and intestinal epithelial cells (IECs) may be functional ingredients in FMT as well. In addition to the abovementioned indications, FMT is also thought to be useful in treating some other diseases in dogs. Consequently, when preparing FMT fecal material, it is important to preserve the functional components involved. Meanwhile, appropriate fecal material delivery methods should be chosen according to the mechanisms these components act by in FMT.
Simulation of an automatic piloting system based on the MATLAB Simulink program for complex production automation
Authors:   BMSTU, Moscow, Yudachev S.S. , Gordienko N.A. ,   BMSTU, Moscow, Gordienko D.A. ,   BMSTU, Moscow, Monakhov P.A. ,   BMSTU, Moscow, Sitnikov S.S. ,   BMSTU, Moscow
Published: December 2022

The main conclusions of the convergence methods are given. The method of proportional approximation is described in detail. Structural schemes are presented: the block of formation of the control action, the block of the kinematic model of the three-contour control system of the object and the blocks of movement of the object "target" and the control object. The work was carried out in a package of application programs for solving MATLAB technical computing problems. The simulation process was performed in the MATLAB Simulink extension. The practical significance of the work is the study of the basic principles of modeling automatic control systems using various methods of convergence; the study of the method of proportional convergence, the creation of models of the movement of objects in the MATLAB Simulink application software package. This work can be used not only for teaching students in the field of development of electronic automatic control devices and for laboratory work, but also in the creation and design of real receiving radio navigation devices both in production and within higher education institutions. Familiarization and studies of the above software are conducted at the Department of Radioelectronic Systems and Complexes of one of the leading engineering universities of the Russian Federation – Bauman Moscow State Technical University.
Median algorithm for estimating the variance of intrinsic noise when detecting a signal with an unknown initial phase
Authors:   Bauman Moscow State Technical University, Moscow, Yudachev S.S. , Monakhov P.A. ,   Bauman Moscow State Technical University, Moscow, Gordienko N.A. ,   Bauman Moscow State Technical University, Moscow, Sitnikov S. S. ,   Bauman Moscow State Technical University, Moscow
Published: December 2022

The article presents the finding of the dispersion of intrinsic noise distributed according to Rayleigh's law to find a signal with an unknown initial phase according to the Neumann- Pearson criterion. This algorithm is used for primary signal processing. The practical significance of the work is the study of the basics of programming in C and Python, comparison and identification of the advantages of this algorithm in comparison with the evaluation by the average value method. It also shows the finding of the threshold at which a decision is made to detect a useful signal. In this work, the integrated programming environment Visual studio was used – a popular environment for writing, debugging and compiling code. It also contains most of the libraries used, which simplify the writing of code. And Anaconda is a distribution for the Python programming language, which includes a set of free libraries, which is also freely available. Using the C language, the task of calculating data and filling it into an array was performed, Python was used for modeling, constructing histograms and comparing the results obtained with theoretical ones. This work can be used for teaching students of higher educational institutions for the purpose of familiarization. The optimal method is considered. Familiarization and study of these programming languages are conducted within the walls of one of the leading engineering universities of the Russian Federation, the Bauman Moscow State Technical University.
Separation of Fumaric and Maleic Acid Crystals from the Industrial Wastewater of Maleic Anhydride Production
Authors: Papraćanin Edisa , Đozić Abdel , Mujkić Ermin , Hodžić Maida , Hodžić Irma , Poljić Belmin , Ramić Ajla
Published: December 2022

In this research, a physicochemical analysis of the industrial wastewater from a factory that produces maleic anhydride was performed. Based on the conducted analysis (pH, electrical conductivity, density of the liquid phase, boiling point of the waste suspension, chemical as well as biological oxygen demand, and dry matter), it can be concluded that the waste stream obtained at the outlet pipe from the plant resulting from the production of maleic anhydride requires appropriate treatments. Some of the parameters measured, e.g. pH (0.97±0.06), boiling point (106.8±1.3°C) and acidity, indicate the presence of organic acids such as fumaric and maleic acids, which are formed during the production of maleic anhydride. The possibility of extracting crystals by adding urea and thiourea followed by forced cooling in a heat exchanger was investigated. The most effective method was the addition of thiourea when the most significant amount of crystals was obtained, namely 17.29 wt%. The addition of thiourea in combination with forced cooling greatly facilitates the process of separating the solid and liquid phases of the waste suspension, which could later be adequately treated by physical, chemical or biological methods.
Improving Communication From Hospital to Skilled Nursing Facility Through Standardized Hand-Off: A Quality Improvement Project
Authors: Baluyot Abigail , McNeill Cynthera , Wiers Susan
Published: December 2022

Background: Inadequate hand-off communication from hospital to skilled nursing facility (SNF) hinders SNF nurses’ ability to prepare for specific patient needs, including prescriptions for critical medications, such as controlled medications and intravenous (IV) antibiotics, resulting in delayed medication administration. This project aims to improve hand-off communication from hospital to SNF by utilizing a standardized hand-off tool. This project was conducted in an inpatient, 50-bed, post-hospital skilled nursing care unit of a local SNF. The participants included all 32 staff nurses employed by the SNF.

Methods: Lewin’s change management theory (CMT) guided this quality improvement (QI) project. Baseline assessment included a one-month chart review of 76 patient charts that was conducted to assess the disparities related to ineffective hand-off and medication delays in the SNF before intervention. The wait time for the availability of prescriptions for controlled medications and IV antibiotics, and delays in medication administration were assessed.

Intervention: Multiple randomly selected hospital-to-SNF hand-offs were observed. Semistructured interviews with all staff nurses were conducted using open-ended questions about hand-off structure and process matters. Data gathered from observation and interviews were used to create the standardized hand-off tool used in this project. In-service training on hand-off tool utilization for SNF nurses was conducted. Champions for each shift were cultivated to assist with project implementation.

Results: After six weeks of implementation, a chart review of 101 patient charts was conducted to evaluate the effects of the hand-off tool on the wait time on the availability of prescriptions for controlled medications and IV antibiotics, and medication administration. The wait time of prescriptions availability during the hospital-to-SNF transition was decreased by 79% for controlled medications, with an associated 52.9% reduction in late administration, and decreased by 94% for IV antibiotics, with a 77.8% reduction in late administration.

Conclusion: The use of standardized hand-off resulted in improved communication during the hospital-to-SNF hand-off and significantly decreased the wait time for the availability of prescriptions for controlled medications and IV antibiotics. Integrating standardized hand-off into the SNF policies can help sustain improved communication, medication management, and patient transition from hospital to SNF.
Searching for Animal Names Through Games
Authors:   Departemen Sistem Informasi, Universitas Komputer Indonesia, Indonesia, Permana Dicky Reza Edina , Suazi Nurkhalis ,   Departemen Sistem Informasi, Universitas Komputer Indonesia, Indonesia, Wibawa Teguh Cahya ,   Departemen Sistem Informasi, Universitas Komputer Indonesia, Indonesia
Published: December 2022

Children are the next generation of the nation where children must have provisions in the form of knowledge. And knowledge can be obtained through learning. The basic nature of children is playing with the introduction of these animal names through games. The purpose of this research is to create a mobile game for children aged 5-7 years that simulates animal name recognition. The research method used in this research is descriptive with a quantitative approach. The results of the research conducted so that children recognize the names of animals. The main concept of this product is game. In the end this game was created to educate children. This simulation is made for children to know the names of existing animals. The game scheme is made in several levels. This research was conducted with the aim of developing games so that they can be a means of learning for children on Android-based mobile devices, to broaden children's horizons, and to determine the feasibility of Android-based learning. With this game can shape the character and development of children.
The Effect of Media Songs and Props on Increasing Interest in Eating Nutritious Food for Children
Authors:   Departemen Pedagogik, Universitas Pendidikan Indonesia, Indonesia, Pasya Hartati Ramadhany , Bayu Dani Nandiyanto Asep ,   Departemen Kimia, Universitas Pendidikan Indonesia, Indonesia
Published: December 2022

This study aims to determine how the influence of media songs and props on increasing interest in eating nutritious food for children. The research method used is a descriptive qualitative method with data collection techniques through questionnaires filled out by 12 early childhood children consisting of four boys and eight girls. This research was conducted in 3 stages, namely (1) pre-test, (2) socialization through songs and props; (3) final test. The results showed there was a change in children's interest in eating nutritious foods, as well as a decrease in children's interest in eating foods that were categorized as less nutritious. This means, the media song and props are quite successfully used in early childhood. From each result of data analysis, it can be seen that the media song and props have a positive impact on increasing interest in eating nutritious food at an early age in Cigugurgirang, Parongpong, Indonesia. With this research, it is expected to increase children's interest in consuming nutritious food so their Nutritional Adequacy Rate (RDA) will be fulfilled.
PURWARUPA SISTEM E-VOTING MENGGUNAKAN ENKRIPSI HOMOMORPHIC DI KOMISI PEMILIHAN UMUM KOTA BANDUNG
Authors: Rajak Aditya Maulana , Agustia Richi Dwi
Published: December 2022

Komisi Pemilihan Umum (KPU) Kota Bandung ingin meningkatkan waktu kecepatan proses pemungutan suara dan rekapitulasi suara dengan memanfaatkan perkembangan teknologi E-voting. Selain permasalahan waktu Komisi Pemilihan Umum Kota Bandung juga ingin mengurangi tingkat pelanggarana terkait validasi hak pemilih seperti yang terdata dalam laporan Evaluasi pelaksanaan pemilihan 2018. serta pelanggaran terkait manipulasi suara yang masuk dalam kategori pelanggaran kode etik penyelenggara pemilu berjumlah 25 orang yang muncul pada Pemilihan Kepala daerah (pilkada) serentak 2018 berdasarkan Laporan Kinerja 2018 Dewan Kehormatan Penyelenggara pemilu. dengan teknologi e-voting yan dikombinasikan dengan face recognition dan enkripsi homomorfik diharapkan permasalahan yang ada dapat terselesaikan. Dari hasil penelitian didapatkan hasil bahwasanya dengan penggunaan e-voting waktu pemugnutan dan rekapitulasi suara menjadi lebih cepat, dengan face recognition permasalhan validasi pemilih dapat dikurangi dan dengan enkripsi homomorfik keamanan terkait data suara dapat ditingkatkan.
PEMBANGUNAN APLIKASI SAYA HEBAT DENGAN MEMANFAATKAN API CLARIFAI UNTUK MEMONITORING KEGIATAN PEMBELAJARAN SISWA DI SLB NEGERI SUKAPURA
Authors: Soritua Alfredo
Published: December 2022

Sekolah luar biasa adalah sekolah yang memfasilitasi Anak Berkebutuhan Khusus (ABK) yang memiliki kelainan dari fisik, mental, down syndrome dan masih banyak lagi. SLBN Sukapura adalah lembaga pendidikan yang diciptakan untuk anak berkebutuhan khusus. Beralamat di Jl. PSM No.2, Sukapura, Kec. Kiaracondong, Kota Bandung, Jawa Barat 40285. Pada sekolah peneliti memfokuskan pada anak berkebutuhan khusus kategori autis pada permasalahan yang ada anak autis susah fokus terhadap suatu pembelajaran yang diberikan sehingga dapat menyebabkan anak tersebut asik terhadap dunianya sendiri, pada permasalahan yang kedua adalah anak tersebut hanya menyukai materi pembelajaran tertentu sehingga materi pembelajaran yang lain diabaikan. Maka peneliti memiliki solusi pada kasus yang ada yaitu membuat aplikasi yang pertama adalah adanya suatu pengingat sehingga anak autisme bisa fokus dan penyampaian materi yang disediakan menggunakan media yang disukai anak tersebut yaitu gambar, video dan materi yang sesuai kebutuhan dengan teknologi yang digunakan adalah API Clarifai dan berbasis android atau disebut E-Learning. Metode pengumpulan data adalah wawancara dan observasi. Dapat disimpulkan hasil akhir dari aplikasi yang dibangun dapat membantu belajar siswa.
PENINGKATAN KEMAMPUAN GURU DALAM PENGGUNAAN APLIKASI KOMPUTER BAGI GURU-GURU MADRASAH ALIYAH AL-FADILLAH
Authors: Nurhayati Sri
Published: December 2022

Kegiatan pengabdian pada masyarakat ini bertujuan untuk meningkatkan kemampuan para guru dalam menggunakan aplikasi komputer dalam hal ini Microsoft office untuk mendukung pembelajaran di sekolah. Penerapan teknologi informasi dan komunikasi akan membuat proses atau kegiatan yang dilakukan menjadi lebih cepat, mudah, dan efisien. Saat ini penggunaan teknologi informasi dan komputer dalam dunia pendidikan memberikan dampak yang baik dalam mendukung proses pembelajaran di sekolah.  Dengan kondisi ini tentunya akan menuntut para guru MA Al-Fadilah untuk dapat menggunakan aplikasi komputer dalam proses proses pembelajaran  seperti bahan ajar, olah nilai siswa, dan lainnya. Namun tidak semua guru dapat menggunakan aplikasi komputer untuk membuat bahan ajar.  Metode yang digunakan dalam kegiatan pengabdian ini berupa pelatihan, diskusi, dan simulasi yang dilakukan melalui daring dengan menggunakan aplikasi Zoom Meeting. Materi pelatihannya berupa aplikasi komputer yaitu Microsoft Office 2013 untuk proses pembelajaran. Setelah dilakukan pelatihan maka kegiatan ini menghasilkan bahwa adanya peningkatan kemampuan guru sebesar 15 % dalam menggunakan aplikasi komputer yaitu Microsoft Office 2013 untuk mendukung proses pembelajaran di sekolah.
PEMBANGUNAN MEDIA PEMBELAJARAN INTERAKTIF MENGGUNAKAN VIDEO 3D HOLOGRAM DI SMPN 25 BANDUNG (STUDI KASUS PEMBELAJARAN DINOSAURUS MASA MESOZOIKUM)
Authors: Nugroho Agam
Published: December 2022

Dinosaurus adalah salah satu hewan paling terkenal di dunia. Tetapi tidak seorang pun pernah melihat dinosaurus yang nyata dan hidup, sebab mereka sudah lama punah. Hewan menakjubkan ini dikenal dari fosilnya. Mata pelajaran tentang dinosaurus sudah dipelajari sejak duduk di sekolah dasar (SD). Ternyata sampai sekarang masih banyak ditemukan guru yang masih menggunakan metode konvensional yang menggunakan buku atau menulis dipapan tulis, berupa tulisan atau text yang banyak dan gambar yang masih 2D (2 Dimensi). Dengan tidak adanya inovasi baru dalam membantu sistem belajar akan membuat beberapa siswa merasa pelajaran menjadi kurang menarik dan membuat siswa tidak memperhatikan pelajaran. Dengan teknologi 3D hologram penulis ingin membantu menyelesaikan permasalahan tersebut dengan membuat aplikasi media pembelajaran interaktif tentang dinosaurus menggunakan frame piramid 3D hologram yang nantinya dari aplikasi tersebut diharapkan bisa digunakan sebagai sarana pembelajaran baru.
PEMBANGUNAN SISTEM INFORMASI KEUANGAN PERUSAHAAN DI PARC C COFFEE & EATERY
Authors: Alfurqon Moch Azzi
Published: December 2022

Parc C Coffee & Eatery merupakan sebuah usaha yang tergolong besar, perusahaan yang di dalamnya terdiri dari usaha caffe, co-working space, dan studio berlokasi di Jl. Kidang Pananjung No. 5C Dago Kota Bandung buka setiap hari dari jam 10.00 WIB hingga 22.00 WIB. Parc-C terinspirasi oleh getaran hangat Prancis dari "parc cafÃ©" yang menjadi ide utama membangun cafÃ© terbaik dan paling nyaman di Bandung.

Pada pengabdian  ini digunakan metodologi penelitian berupa metode deskriptif. Sedangkan untuk metode pengumpulan data menggunakan metode wawancara, observasi, dan studi dokumentasi. Kemudian menganalisa dan menjelaskan data yang dikumpulkan sesuai dengan tujuan pengabdian untuk pembangunan sistem yang digunakan metode waterfall, dan untuk pemodelan sistem menggunakan metode perancangan orientasi objek dengan alat bantu perancangan yaitu flowmap, dan use case, dan kamus data. Dalam pengabdian ini menggunakan bahasa pemrograman PHP dengan menggunakan framework Codeigniter untuk membuat program dan menggunakan MySQL sebagai database.

Tujuan dari pengabdian ini diharapkan dapat mempermudah dalam mengelola administrasi keuangan perusahaan menjadi lebih cepat, tepat dan akurat. Setelah sesuai dengan metode penelitian yang diinginkan, sistem informasi ini memiliki tindak lanjut pengujian sistem dimana pengujian ini menggunakan metode black box.
PELATIHAN MS ACCESS UNTUK PETUGAS ADMINISTRASI DI RW 08 BUMI ADIPURA BANDUNG
Authors: Anthara I Made Aryantha , Andriani Diana , Ramadhan Ahmad Akbar , Adiningrat Muhammad Yusuf
Published: December 2022

Teknologi informasi merupakan hal yang penting dalam kondisi globalisasi seperti saat ini. Pemanfaatannya dapat digunakan dalam berbagai macam kegiatan. Dalam pengabdian masyarakat ini akan menggunakan salah satu jenis dari teknologi informasi yang ada yaitu penggunaan sistem informasi yang berbasis Microsoft  Access.Tempat yang dijadikan objek dalam pengabdian masyarakat kali ini adalah RW 08 yang terletak di Perumahan Bumi Adipura Bandung. Pada saat ini, pelayanan terhadap warga dalam hal pembuatan surat pengantar dan pembayaran iuran warga masih menggunakan cara tradisional. Hal ini dapat berpengaruh terhadap lamanya pelayanan kepada warga.Untuk dapat mempercepat proses pelayanan terhadap warga, maka dalam kegiatan pengabdian masyarakat ini akan diadakan pelatihan Ms Access kepada petugas administrasi yang ada di lingkungan tersebut.Tujuan yang diharapkan dalam kegiatan ini diantaranya dapat memberikan pemahaman kepada petugas administrasi untuk dapat menggunakan system informasi sehingga pelayanan kepada warga bisa lebih cepat.Metode yang digunakan dalam kegiatan ini adalah menggunakan metode daring dengan menggunakan aplikasi ZOOM dengan peserta yang berasal dari pengurus setempat, petugas administrasi dan juga instruktur pelatihan. Kendala yang dihadapi selama pelatihan, diantaranya masih kurangnya pemahaman dari petugas administrasi terhadap sistem informasi yang sudah dibuat. Dengan adanya sistem informasi ini, diharapkan pelayanan terhadap warga akan lebih cepat sehinga proses administrasi di RW 08 bisa berjalan lebih baik lagi.