bluuebunny/crossref_metadata_2025 huggingface dataset:
Distributed Regression Analysis Application in Large Distributed Data Networks: Analysis of Precision and Operational Performance (Preprint)
Authors: Her Qoua , Malenfant Jessica , Zhang Zilu , Vilk Yury , Young Jessica , Tabano David , Hamilton Jack , Johnson Ron , Raebel Marsha , Boudreau Denise , Toh Sengwee
Published: June 2019

BACKGROUND

A distributed data network approach combined with distributed regression analysis (DRA) can reduce the risk of disclosing sensitive individual and institutional information in multicenter studies. However, software that facilitates large-scale and efficient implementation of DRA is limited.

OBJECTIVE

This study aimed to assess the precision and operational performance of a DRA application comprising a SAS-based DRA package and a file transfer workflow developed within the open-source distributed networking software PopMedNet in a horizontally partitioned distributed data network.

METHODS

We executed the SAS-based DRA package to perform distributed linear, logistic, and Cox proportional hazards regression analysis on a real-world test case with 3 data partners. We used PopMedNet to iteratively and automatically transfer highly summarized information between the data partners and the analysis center. We compared the DRA results with the results from standard SAS procedures executed on the pooled individual-level dataset to evaluate the precision of the SAS-based DRA package. We computed the execution time of each step in the workflow to evaluate the operational performance of the PopMedNet-driven file transfer workflow.

RESULTS

All DRA results were precise (<10−12), and DRA model fit curves were identical or similar to those obtained from the corresponding pooled individual-level data analyses. All regression models required less than 20 min for full end-to-end execution.

CONCLUSIONS

We integrated a SAS-based DRA package with PopMedNet and successfully tested the new capability within an active distributed data network. The study demonstrated the validity and feasibility of using DRA to enable more privacy-protecting analysis in multicenter studies.
In silico study of COX-2 on indomethacin and diclofenac as nonsteroidal anti-inflammatory drugs (NSAIDs)
Authors: Na'imah Janatun
Published: June 2019

Cyclooxygenase is an enzyme that plays a role in the formation of prostaglandins, which can cause inflammation and pain when overexpressed. This study aims to determine the interaction between COX-2 macromolecules (receptors) with their ligands, namely indomethacin and diclofenac in silico using the Molecular Docking method. The COX-2 receptor was downloaded in the form of a 3D structure from the RCSB GDP with code 5F19. Diclofenac Ligand and Indomethacin were downloaded in the form of a 3D structure from the RCSB GDP with 4ZBQ code and 4IK7 code. The results showed that the interaction between COX-2 and indomethacin was the interaction of hydrogen, which linked indomethacin with amino acid Leu531 and steric interactions between indomethacin and amino acids Trp387, Tyr385, Tyr355, Leu352, and Val523. The interaction of [COX-2 – Indomethacin] produces a value of ∆G of -103.136 kcal/mol, and the value of RMSD is 1.244 Å. Whereas, the interaction that occurs in COX-2 with diclofenac is the steric interaction that happens between diclofenac with amino acids Leu390, Trp387, Gln203, His388, His207, and Thr206. The interaction parameter between [COX-2-Diclofenac] obtained ∆G value of -7.843 kcal/mol and an RMSD value of 2.07851 Å.
House Yard Medicinal Plants of Dusun Kampung Baru Society as Biology Learning Resources of SMA Negeri 1 Merlung Tanjung Jabung Barat
Authors: Hidayat Rahmat , Fahrul Muhammad , Erama Faizah Claresta , Alvionita Sofia
Published: June 2019

Medicinal plants in house yard of Dusun Kampung Baru Society in Merlung village have a potential to be learning resources for schools around the village, especiallyfor SMA Negeri 1 Merlung. The objective of this study is to know the feasibility of biodiversity of medicinal plants as biology learning resourcesfor the students of SMA Negeri 1 Merlung. The results of this study showed that Kampung Baru society planted 21 species of medicinal plants belonging to 18 families, in the form of herbaceous plant, shrubs, and trees. There were 21 types of diseases that can be treated with these plants, by using leaves, fruit, rhizomes, or sap. House yard and its medicinal plants classified as a learning resources by utilization in the form of setting. The feasibility as learning resourcesbased onthe value of utilizations to the society. House yard and its medicinal plants can be called living laboratories, because it was a small ecosystem with a diversity of plants that are used by the community in the form of knowledge of utilization of medicinal plants. Through contextual learning, students are trained to be critical and analytical in gaining information and constructing a complete knowledge about subject matter with its application in society.

Keywords: Medicinal plants, haouse yard, learning resources, contextual learning

Abstrak. Tanaman obat pekarangan Masyarakat Dusun Kampung Baru Desa Merlung berpotensi menjadi sumber belajar bagi sekolah-sekolah di sekitar desa, salah satunya ialah SMA Negeri 1 Merlung. Tujuan penelitian ialah untuk mengetahui kelayakan keanekaragaman tumbuhan obat pekarangan tersebut sebagai sumber belajar biologi SMA Negeri 1 Merlung. Hasil penelitian menggambarkan bahwa Masyarakat Dusun Kampung Baru menanam 21 jenis tanaman obat yang tergolong ke dalam 18 famili, berupa tumbuhan herba, perdu, dan pohon. Terdapat 21 jenis penyakit yang dapat diobati dengan tanaman-tanaman tersebut, baik dengan memanfaatkan daun, buah, rimpang, atau getah. Pekarangan dan tumbuhan obat di dalamnya digolongkan sebagai sumber belajar termanfaatkan (by utilization) yang berbentuk latar lingkungan (setting). Kelayakannya sebagai sumber belajar disebabkanoleh nilai manfaatnya bagi masyarakat. Pekarangan dan tanaman obat di dalamnya dapat disebut sebagai laboratorium hidup karena menjadi ekosistem kecil dengan keanekaragaman spesies tumbuhan yang dimanfaatkan oleh masyarakat dalam wujud pengetahuan pemanfaatan tanaman obat. Melalui pembelajaran kontekstual, siswa dilatih agar kritis dan analitis dalam menggali informasi dan mengonstruksi bangunan ilmu yang utuh tentang materi pelajaran dengan penerapannya di masyarakat.

Katakunci:Tanaman obat, pekarangan, sumber belajar, pembelajaran kontekstual
Los primeros 10 años de Cuadernos de Investigación UNED: bibliometría de temas, autores e instituciones
Authors: Monge-Nájera Julián , Seas Carolina
Published: June 2019

Introducción: Costa Rica es el país centroamericano con más estudios bibliométricos, sin embargo, muy pocos son sobre las tendencias históricas de revistas académicas particulares. Objetivo: Analizamos las tendencias estadísticas de la primera década de la revista Cuadernos de Investigación UNED, considerando cuatro temas: quiénes publican, qué publican, cómo han variado las tendencias a lo largo del tiempo y qué podemos esperar en el futuro. Resultados: La cantidad de cuadros por artículo fue alta al inicio, luego más bajo, oscilando de forma estable entre 2 y 3. La cantidad de figuras por artículo oscila entre 2 y 5. Los artículos han tendido a acortarse. La cantidad de autores por artículo oscila entre 2 y 3. Autoras ha oscilado entre un tercio y la mitad. Las seis personas con mayor cantidad total de artículos publicados son de la Universidad Estatal a Distancia (UNED), seguida de la Universidad de Costa Rica (UCR); la mitad, mujeres. Predominan los artículos sobre Costa Rica, seguidos de lejos por el resto de América Latina, África y Asia. Artículos provenientes de Costa Rica se ha cuadriplicado. En cuanto al país de los autores, Costa Rica domina fuertemente. Las instituciones que predominan como fuentes de artículos son la UNED, UCR y la Universidad Nacional de Costa Rica (UNA). UNED ha sido estable, UCR cada 5 años parece aumentar, Universidad Nacional de México ha disminuido. Quienes publican sobre Costa Rica son autores costarricenses. Aumento de los artículos en español es más marcado y constante. Conclusión: Los patrones históricos coinciden con el de otras revistas científicas como Biología Tropical que, aunque publicadas en países pequeños, se insertan en el mundo mucho más amplio de la ciencia internacional.
Effect of Indoleacetic Acid and Zinc Sulphate Application on Growth and Some Physiological Parameters of Cowpea (Vigna sinensis Savi) Plants
Authors: Tahir Ikbal Muhammed Gharib , Khudur Sargul Ahmad , Anwar Arol Mohsen
Published: June 2019

This study was conducted in Koya city, Iraq on cowpea (Vigna sinensis Savi) plants California black eye variety by factorial experiment including the effects of foliar spraying of Zinc Sulphate ZnSO4.7H2O (ZS) or the plant growth regulator Indoleacetic Acid C10H9NO2 (IAA). Analysis of data revealed that ZS and IAA application affects significantly on the studied traits. 100 ppm of IAA increased significantly the leaves content of each of chlorophylls a, b, and total, although it decreased the content of total carotenoids. The results showed that the leaf area significantly increased by increasing the amount of ZS to 2.0 g/L compare with other treatments except 1.0 g/L ZS application. Foliar application of IAA increased significantly the dry matter percent of shoots and roots as well as the number of nodules per plant. It has been found that leaves content of zinc is related to the concentration of ZS applied significantly compared to the control and IAA treatments, however, the application of IAA caused to decrease K and Zn contents in leaf of the plants compared to other treatments. Finally, based on the results the best ratio of IAA for increased stomata number on the abaxial and adaxial leaves surfaces was 75 ppm.
Website Design for Hoarding Portal Management (HPM)
Authors: Chourey Sawan
Published: June 2019

Introduction  Hoarding Portal Management (HPM) is made to coordinate the uncentralized and unorganized business of hoardings.  Hoardings are basically used as a medium of advertisement and it expands to big business as it exists from big cities to small towns. Purpose  Thought of Hoarding Portal Management System totally revolutionizes the mind of a normal man. Getting all types of information , that one need at their doorstep just on the effort of few clicks of mouse. Hoarding Portal Management System is a System that is going to provide all  facilities to user . Not only Normal User but also administrator is going to get benefit from this system. Apart from managing details of different types of hoardings , agencies available in different regions and cities , different analysis reports from the record can also be fetched.
TO THE PROBLEM OF TOTAL EVALUATING OF DREDGING IMPACT ON VARIOUS SYSTEMATIC GROUPS OF AQUATIC BIOLOGICAL RESOURCES OF THE NOVOTROITSK RESERVOIR IN THE STAVROPOL REGION
Authors: Denisenko Oleg Sergeyevich
Published: June 2019

The article highlights the poor ecological conditions of the Novotroitsk reservoir in the Stavropol Territory due to its intensive siltation because of the erosion of the banks and riverbed of the Egolik river, forming extensive stagnant zones and waterlogging of individual sections and secondary organic pollution of the reservoir, which necessitated a set of measures for hydromechanical cleaning of the reservoir bottom from silt sediments. There have been given the results of comprehensive studies of the possible impact of dredging by hydro-mechanization using pile-anchor dredger “350-50L” on the aquatic biological resources of the Novotroitsk reservoir. The hydrological, hydrobiological and ichthyological characteristics of the biota of the Novotroitsk reservoir are given, the technological solutions used in the course of dredging are fully described, the influence of the dredging on various systematic groups of hydrobionts of the reservoir is considered. According to the current regulatory legal acts of the Russian Federation in the fisheries and saving aquatic biological resources, there has been carried out calculation of harm caused to the aquatic biological resources. In view of the research results, the main features of the negative impact have been identified and the total amount of harm caused to the aquatic biological resources of the Novotroitsk has been calculated reservoir in natural terms. Using a certified computer model of IMRV “Potok” 1.0 there has been conducted simulation mathematical modeling of propagation and sedimentation of additional turbidity. The values of change variability of the suspended solids concentrations depending on the distance, the integral volumes of suspension tails and redeposition areas of turbidity zones on the bottom of the Novotroitsk reservoir relative to the month of conducting the work and to the seizures of the extracted soil have been calculated. Various compensatory measures for restoration of water bioresource losses have been developed.
ASYMMETRY OF BREAM SKELETON BILATERAL FEATURES IN THERMOELECTRIC POWER STATIONS BASIN-COOLERS IN THE MIDDLE URALS
Authors: Baranov Vadim Yurievich
Published: June 2019

The article analyzes the bilateral structures asymmetry of bream Abramis brama (Linnaeus, 1758) populations in pilot reservoirs (lake Shitovskoye, pond Sylvinskiy) and populations of impact basin-coolers of the thermal power stations (lake-reservoir Isetskoye, reservoir Reftinskoye) in the Middle Urals, which was carried out using 27 non-metric skeleton features. The non-metric features analysis was implemented on 4 bream paired head bones. 10 dentale features, 4 operculum features, 7 praeoperculum features and 6 pteroticum features were studied. There has been calculated the dispersion of directional DA 2, fluctuating FA 2, total asymmetry TA 2 and the values of asymmetry indices FAnm . The fluctuating asymmetry FA 2 is found to contribute the most part (72-84 %) to the total asymmetry ТА 2 of bilateral features. The share of dispersion of directional asymmetry DA 2 in the dispersion of total asymmetry TA 2 is 16-28%. Intergroup differences between control and impact bream samples in the dispersion of directional asymmetry DA 2 was not significant ( p > 0.001). Significant increase in the dispersion of fluctuating asymmetry FA 2 and the values of individual asymmetry indicators FAnm have been identified in impact bream populations of thermal power station basin-coolers ( p < 0.001). The increased level of fluctuating asymmetry indirectly indicates destabilization of the bream morphogenesis in long-term habitat under thermal and chemical pollution. The results of the study can be used for organizing and conducting the environmental monitoring to assess the condition of bream populations in technologically disturbed reservoirs
The Principle of Event Capture in Philosophical and Anthropological Research: an Interdisciplinary Approach
Authors:   Perm National Research Polytechnic University, Museev Nikolay Aleksandrovich
Published: June 2019

The study discusses the possibilities of an interdisciplinary approach in philosophical and anthropological research and the possible construction of an interdisciplinary anthropological project relevant to the contemporary intellectual situation. The hermeneutic clarification of the initial attitudes of philosophical anthropology helps identify that the modern understanding of man as a dynamic structure changes the approach to comprehending his essence. The disclosure of the essential characteristics of a person is based on the comprehension of his “self” implemented during his interaction with the world. The study deals with a combination of such topics as man, culture, language, and experience and implies the interdisciplinary nature of problems. The research presents the event-based anthropological project that is founded on the achievements of event ontology, philosophy of culture and linguistics. The emphasis is placed on the effect of event experience in achieving the existential characteristics of the individual. The novelty of the study lies in the principle of event capture (capture is interpreted as the determination of the subject by the chronotopic structures of the event) that is the conceptual foundation of the philosophical and anthropological approach. The creative revision of the teachings of M. Heidegger, M. Scheler, and M. Foucault serves as the methodological basis for the study of man in the context of event capture.
NKVD Special Reports on Anti-Soviet Sentiments of the Yaroslavl Railway Workers at the Initial Stage of the Great Patriotic War
Authors:   Russian University of Transport, Veterkov Aleksandr Ivanovich
Published: June 2019

The study discussed the anti-Soviet sentiments expressed by the Yaroslavl Railway workers at the initial stage of the Great Patriotic War (1941-1942). This period preceded the radical change in the war and was the most difficult and tragic time in its history. The unpredictable outcome of the war, heavy territorial and human losses led to the anti-Soviet sentiments which concerned railway workers as well. The study revealed that defeatist thoughts, famine and other war hardships generated the anti-Soviet opinions, but they were not anti-state in nature. Nevertheless, society faced the pro-German sentiments caused mainly by Stalinist repression, the closure of churches, the creation of collective farms, the omnipotence of the Communists, and the hostility towards the Jews.
PENINGKATAN HASIL BELAJAR PESERTA DIDIK DENGAN MENGGUNAKAN MEDIA AUDIO VISUAL PADA MATA PELAJARAN IPA DI KELAS IIISDN 50 BULU DATU PALOPO
Authors: Arlianti Arlianti
Published: June 2019

The purpose of this study was to determine the use of audio-visual media that can improve science learning outcomes in the third grade of SD 50 Bulu Datu. This research is classroom action research (PTK) with qualitative and quantitative research types consisting of two cycles each cycle 3 meetings, data collection techniques carried out by observing, testing, documentation with the stages of planning, implementation, observation, reflection. The results showed that: by using audio-visual media in science learning the learning outcomes of students increased, it can be seen in the data obtained which showed that the average value in class III in the first cycle reached 73 but there were still several students who are still lacking and the researchers proceed to cycle II, the learning outcomes of students increase with the results of the average score reaching 95 based on minimum completeness criteria (KKM) in science subjects have achieved results and researchers end this research until the second cycle.
EFEKTIVITAS PEMBERIAN PENGUATAN BERKEARIFAN LOKAL TERHADAP MOTIVASI BELAJAR ILMU PENGETAHUAN SOSIAL(IPS) SISWA DI KELAS III SD ISLAM DATOK SULAIMAN BAGIAN PUTRI PALOPO
Authors: Darnia Darnia
Published: June 2019

This study aims to determine the provision of strengthening local wisdom and knowing the motivation to learn Social Sciences (IPS) students in the subject matter of the natural environment and the artificial environment through the provision of local wisdom strengthening in class III SD Islam Datok Sulaiman Palopo. This study uses a type of experimental research with a design or design Quasi Experimental Design using the research technique Nonequivalent Control Group Design. Data in the study were collected using observation, testing, and documentation techniques. The results of this study indicate that the provision of local wisdom reinforcement is effective for increasing students' learning motivation in Social Sciences. It is evident from the results of descriptive statistical analysis that the average score of Social Sciences learning outcomes of experimental class students is 81.03 while the average score of the learning outcomes of the control class is 66.81. The results of inferential statistical analysis obtained zhit = 3.92 with a significant level of 5% obtained ztab = 1.64 means zhit > ztab which causes H0 to be rejected and H1 accepted. This shows that the learning motivation of Social Sciences students whose learning applies local wisdom reinforcement is better than the learning motivation of Social Sciences students who study without applying the provision of local wisdom. Thus, the provision of strengthening local wisdom is one of the effective ways to increase students' learning motivation in Social Sciences.
PENGGUNAAN MEDIA KONKRET UNTUK MENINGKATKAN HASIL BELAJAR MATEMATIKA POKOK BAHASAN GARIS BILANGAN PADA PESERTA DIDIK KELAS III MI DATOK SULAIMAN KOTA PALOPO
Authors: Sulviani Sri
Published: June 2019

This research is a Classroom Action Research (CAR) which is the main problem of the low level of mathematics learning outcomes of class III students of MI Datok Sulaiman Palopo City. The research subjects were MI Datok Sulaiman third grade students in the odd semester of 2018/2019 school year with 28 students. This study was carried out in two cycles with number line material. Data collection techniques used consist of tests, observations, and documentation. Data processing and analysis techniques used are quantitative data analysis and qualitative analysis. The results showed that the learning outcomes with the number line material obtained by the average learning outcomes of students in cycle I was 64.85 including the category of not achieving the KKM score (Minimum Completeness Criteria) with the number of students completing learning were 11 people with a percentage of 39%, and learning outcomes in the second cycle on average obtained 82.89 including very good category with the number of students completing 26 with a percentage of 93%. This research was declared successful with the use of concrete media to improve mathematics learning outcomes.
Suvivirsi ja kristinuskon ”kulttuuristuminen” katsomuksellisen monimuotoisuuden aikana
Authors: Taira Teemu
Published: June 2019

Suvivirren laulaminen koulujen kevätjuhlissa on keskustelunaihe, jolta on vaikea välttyä. Tässä artikkelissa kysytään, miten Suvivirrestä keskustellaan suomalaisessa mediassa. Tarkastelu keskittyy erityisesti siihen, miten Suvivirttä luokitellaan ja millaista kulttuurista todellisuutta luokitteluilla ja puheilla rakennetaan. Keskustelu Suvivirrestä kiihtyy huomattavasti 1990-luvun puolivälistä alkaen. Tyypillisesti ne, jotka pitävät laulua perinteen osana, puolustavat sen laulamista koulujen päättäjäisissä. Ne, jotka pitävät sitä uskonnollisena (tai sen laulamista uskonnon harjoittamisena), tavallisesti vastustavat laulamista. Riippumatta luokittelusta ja laulamiseen suhtautumisesta tässä keskustelussa jaetaan käsitys sekä koulujen sekulaariudesta – siitä, että uskonnonharjoittaminen ei kuulu koulujen yhteisiin tilaisuuksiin – että Suomen katsomuksellisesta monimuotoisuudesta, mikä ilmenee puheena vähemmistöistä. Samankaltaisten kansainvälisten tapausten vertailun perusteella artikkelissa ehdotetaan, että suvivirsikeskustelua luonnehtii kristinuskon ”kulttuuristuminen”. Se tarkoittaa tyypillisesti uskonnollisiksi luokiteltujen symbolien ja käytäntöjen luokittelua riittävässä määrin kulttuuriksi ja perinteeksi. Artikkelissa ehdotetaan, että ”kulttuuristuminen” ylläpitää valtakirkkojen hegemoniaa yhteiskunnassa.
Accessory genital glands in the New Zealand White rabbit: a morphometrical and histological study
Authors: Skonieczna Joanna , Madej Jan P. , Będziński Romuald
Published: June 2019

Introduction: The aim of this research was to provide a detailed description of the morphology, topography, and histometry of rabbit accessory genital glands. Material and Methods: Seven male New Zealand White rabbits, 3–4 months of age and weighing 2.1–3 kg were used for the study. The whole urethra from the urinary bladder to the external urethral orifice accompanied by accessory genital glands was sliced at intervals of 1 mm. The serial sections were prepared with haematoxylin-eosin (H&E) and Movat–Russell modified pentachrome stain. Results: A detailed description of the morphology and morphometry was provided. The topography of the organs was explained on the basis of characteristic cross-sections on histological slides. The inconsistent nomenclature and descriptions of these glands by different authors were also discussed. Conclusion: The morphometric analysis indicated that some of the glands described have similar dimensions in different individuals, while others like paraprostates revealed high diversity in the number of lobes, their size, and their structure. The accessory glands are also good topographic markers which precisely define the segment of the urethra. The terms “proprostate”, “prostate”, and “paraprostates” as the nomenclature of the prostate complex reflect the location of these glands well and indicate their common origin and function.
Haemodynamics imaging of swine segmental kidney artery using duplex Doppler technique
Authors: Aleksiewicz Roman , Lutnicki Krzysztof , Bojarski Marcin , Al-Mutari Ilona , Bocheńska Aneta
Published: June 2019

Introduction: The aim of the study was to assess the usefulness of duplex Doppler to objectify swine renal arterial flow in physiological conditions. The pig kidney was selected for its morphological similarities to the human and for the results therefore offering data to wider research. Material and Methods: Six White Large x Landrace sows, of 48.5–53 kg b.w. were used. Vascular flow parameters were acquired with a convex probe USG device with a duplex Doppler function using pulsed waves (frequency range of 5–7.5 MHz). Segmental kidney arterial flow was measured. Results: The RI values were within the 0.57 (min) to 0.6 (max) range, ̄xRI was 0.58 (±0.014), and the SD2 value was 0.0002. The PI index values ranged from 1.21 (min) to 1.3 (max), and ̄xRI was 1.24 (±0.035). The value of SD2 was 0.00123. In the S/D index, the results fell between 2.2 (min) and 2.49 (max), with ̄xS/D of 2.29 (±0.117). The value of variance SD2 was 0.0139. A double analysis of correlation between indices showed this to be almost certain and highly positive as confirmed by high correlation coefficients: r RI & PI 0.857, rho
RI & PI 0.739, r
RI & S/D 0.930, rho
RI & S/D 0.941, r
PI & S/D 0.913, and rho
PI & S/D 0.754. The segmental kidney arterial flow spectrum evinced falls in PSV and PSV/LDV ratio, also noticed in the filling of the spectral window, comparing the renal to an interlobar artery. Conclusion: Swine were selected because of renal anatomical and haemodynamic similarity to humans. The most relevant values and indices approximated those in humans. The study anaesthetic protocol had a minor influence on the average RI, PI, and S/D indices.
PEMODELAN INUNDASI DAN WAKTU TIBA TSUNAMI DI KOTA BITUNG, SULAWESI UTARA BERDASARKAN SKENARIO GEMPABUMI LAUT MALUKU
Authors: Sriyanto Sesar Prabu Dwi , Nurfitriani Nurfitriani , Zulkifli Muhammad , Wibowo Sandy Nur Eko
Published: June 2019

Kota Bitung sebagai salah satu kawasan strategis dan pusat perekonomian di Sulawesi Utara, berpotensi terdampak oleh bencana tsunami karena berada di pesisir Laut Maluku yang bisa menjadi lokasi pusat gempabumi besar pemicu tsunami. Untuk mengetahui potensi area terdampak dan waktu tiba tsunami di wilayah Bitung, dilakukan pemodelan penjalaran tsunami dengan skenario gempabumi Mw 7,9 dengan episenter di Laut Maluku menggunakan perangkat lunak TUNAMI-N2 (Tohoku University’s Numerical Analysis Model Investigation of Tsunami No 2). Data yang digunakan berupa parameter skenario gempabumi pembangkit dan data elevasi. Data elevasi terdiri dari data topografi primer hasil pengukuran lapangan menggunakan altimeter digital dan data sekunder berupa data batimetri dari GEBCO (General Bathymetric Chart of The Ocean) dan data topografi daratan SRTM (Shuttle Radar Topographic Mission) dari USGS (United States Geological Survey). Hasil pemodelan menunjukkan bahwa tsunami pertama kali mencapai di wilayah Bitung tepatnya di pantai timur Pulau Lembeh pada detik ke-520 setelah gempabumi. Ketinggian maksimum tsunami bisa mencapai 7,625 meter, sedangkan inundasi terjauh dan potensi area tergenang masing-masing mencapai 750 meter dan 2,1 km2. Lokasi dengan tingkat bahaya tertinggi ada di sebelah barat Pelabuhan Bitung karena topografi yang landai dan berhadapan dengan perairan yang berbentuk teluk sehingga terjadi amplifikasi gelombang. Pantai yang berbentuk teluk ini juga menyebabkan gelombang tertinggi terjadi pada gelombang yang kedua.
PENGARUH WAKTU TAHAN PADA PROSES ARTIFICIAL AGING TERHADAP KEKERASAN PADUAN Al-Sn-Cu
Authors: Prayitno Dody , Apriandini Fitri Azhary
Published: June 2019

Artificial aging adalah proses pemanasan kembali larutan padat jenuh ke suatu temperatur di bawah garis solvus dan dibiarkan pada temperatur tersebut selama jangka waktu tertentu. Pada penelitian ini akan dilakukan artificial aging pada paduan aluminium timah (Al-Sn) dengan penambahan variasi logam Tembaga (Cu). Tujuan penelitian adalah mengetahui pengaruh waktu tahan pada proses artificial aging terhadap kekerasan dan mikrostruktur AlSn-Cu. Ruang lingkup penelitian sebagai berikut, material adalah Al-10Sn-0Cu; Al-10Sn- 10Cu dan Al-10Sn-20Cu Suhu solid solution adalah 500 oC. Suhu aging 190 oC. Waktu penuaan adalah 1jam, 5 jam dan 10 jam. Hasil penelitian menunjukkan peningkatan waktu penuaan dari 1 jam hingga 10 jam meningkatkan kekerasan paduan Al-10Sn -10Cu dan paduan Al-10Sn-20Cu.
TINJAUAN YURIDIS TERHADAP HAK WARIS ANAK HASIL PERKAWINAN SIRI
Authors: Rusydi Ibnu
Published: June 2019

Masyarakat Indonesia mengenal istilah perkawinan siri sebagai perkawinan yang sah secara hukum Islam tetapi  tidak dicatatkan di KUA (Kantor Urusan Agama), sehingga   keabsahan   dari   perkawinan   tersebut   tidak   diakui   oleh   negara. Berdasarkan Undang-Undang Repubik Indonesia Nomor 1 Tahun 1974 tentang Perkawinan bahwa setiap perkawinan harus dicatatkan agar tercapai ketertiban dalam masyarakat.  Salah satu dampak negatif yang ditimbulkan dari perkawinan siri adalah tidak adanya kekuatan hukum yang mengikat atas perkawinan tersebut, negara menganggap bahwa perkawinan  siri  tersebut  tidak  pernah  ada,  karena tidak  adanya bukti berupa akta nikah. Perkawinan siri dapat menimbulkan beberapa masalah berkenaan dengan hak waris anak yang lahir dari perkawinan siri seperti bagaimana perlindungan hukum terhadap hak waris anak pada perkawinan siri menurut hukum negara Indonesia, bagaimana akibat hukum dari anak pada perkawinan siri terhadap pewarisan menurut hukum negara, dan bagaimana penyelesaian hukum dalam pewarisan anak pada perkawinan siri menurut hukum negara Indonesia.
Reformation der Kirche oder Reformation durch Kultur?
Authors: Raynova Yvanka B.
Published: June 2019

Ediorial
Sífilis congênita no estado do Pará-Brasil, 2007 a 2016
Authors: Silva Luísa Margareth Carneiro da , Dias Rosa Maria , Frazão Andrea das Graças Ferreira , Rezende Ana Lúcia da Silva , Moura Fernanda Maria Lima , Araújo Eliete da Cunha , Pinheiro Maria da Conceição Nascimento , Rodrigues Anderson Raiol , Souza Ana Maria  Almeida , Leão Paula Valente
Published: June 2019

Objetivo: Estimar a incidência e fatores associados à sífilis congênita (SC) nas Regiões Geográficas Intermediárias (RGIs) no Estado do Pará. Método: Estudo descritivo, quantitativo, analítico, sobre SC no Pará, utilizando dados do Sistema de Informação de Agravos de Notificação de 2007 a 2016. Resultados: Aumento dos casos de SC, sendo Belém e Marabá as RGIs com mais casos. As variáveis que se associaram (p<0,05) com a ocorrência de SC, foram escolaridade materna (RR=1,06; IC95% 1,00-1,25) e cor da pele não branca (RR=0,71; IC95% 0,66-0,77).Altamira teve o maior percentual de mães com idade menor de 20 anos. A realização do pré-natal variou (65,8% a 90,1%). O diagnostico durante o pré-natal teve variação expressiva. Tratamento inadequado das mães e parceiros não tratados prevaleceram nas Regiões Altamira e Marabá, respectivamente. Conclusão: Aumento da incidência em mulheres maiores de 20 anos, em todas RGIs. O tratamento inadequado, ausência de tratamento do parceiro e diagnóstico de sífilis após o parto foram expressivos, justificando a alta incidência da SC.
Redes sociais como elemento para a promoção da saúde de adolescentes: contribuições da enfermagem
Authors: Thomas Larissa Scheeren , Fontana Rosane Teresinha
Published: June 2019

Objetivo: Identificar dúvidas e inquietações do adolescente acerca da saúde, e, socializar e educar em saúde por meio de redes sociais. Metodologia: Trata-se de uma pesquisa exploratória, descritiva, com abordagem qualitativa. Os dados foram coletados mediante o uso de um questionário com duas perguntas abertas, a estudantes do oitavo e nono ano do ensino fundamental, de quatro escolas municipais de dois municípios do interior do Rio Grande do Sul, no primeiro semestre de 2018. O tratamento dos dados seguiu a análise de conteúdo na modalidade temática. Os participantes da pesquisa foram estudantes do ensino fundamental. O estudo respeitou os preceitos éticos da pesquisa em seres humanos. Resultados: A maioria dos questionamentos envolveram dúvidas sobre câncer, dores, infecções sexualmente transmissíveis, alimentação e exercício físicos. Conclusão: Pode-se inferir que a saúde ainda é um tema que desperta muita curiosidade e as redes sociais, se bem conduzidas, podem ser uma ferramenta de socialização e empoderamento do estudante nesta área.
Using brochure as a media in teaching reading descriptive text among the eight grade students of SMPN 1 Jiwan
Authors: Kartikasari Laelly , Ningsih Nuri Ati , Pinandhita Fitra
Published: June 2019

The objectives of this research are: 1) to know how is the implementation of Brochure to teach reading for the eight grade students of SMPN 1 Jiwan, 2) to find out the advantages of the implementation of brochure to teach reading for the eight grade students of SMPN 1 Jiwan, 3) to find out the disadvantages of teaching reading descriptive text to the eight grade students of SMP N 1 Jiwan in schoooling year of 2016/2017. The research approach and type of this research is descriptive qualitative research. This research was held on SMP N 1 Jiwan, focus on the eight grade students. The source of data of this research are social situation, participant and document. The participant of this research are the students of class VIII G. In this research, the researcher as observer in the class. To get the data, the researcher uses observation, interview, and documentation. The technique of data analysis that used in this research are data condensation, data display, and drawing or verifying conclusion. The result of the research are 1) the implementation of Brochure as a media to teach reading divided into three stages, they are (a) pre- activities included greeting, checking students’ attendance, and build background knowledge, (b) whilst activities included giving the explanation about the materials, and the implementation of brochure as a media, (c) post activities included review the materials, asking the students difficulties, gives a conclusion, and closing. 2) the advantages and disadvantages of the implementation of brochure as a media. The advantages are to increase the students interesting in following teaching reading, this media can helps the students to finish their task to answer all the questions, and to makes the students do not feel bored in teaching reading process. While, the disadvantages by using brochure that are some students still passive during teaching reading process, the students have less vocabularies make the students feel difficult to translate the meaning of the text. Based on the research, the researcher gives some suggestion. The teacher is suggested to use this media especially in teaching reading descriptive text. The students should increase their vocabulary in order to makes the students be easier to understand the meaning of the text. The future researcher are suggest to conduct other research in english teaching especially for teaching reading.
Generic structure potential of rollingstone magazine cover february 9th, 2006 edition; critical multimodal discourse analysis
Authors: Putranto Kristian Dwi , Ricahyono Sigit , Ambarwati Rosita
Published: June 2019

Rollingstone; February 9th, 2006 edition was made because there is the meaning intended on it. The researcher uses critical multimodal discourse analysis from O’Halloran (2004), Kress and Van Leeuwen (2006), Halliday and Matthiessen (2014). The objectives of this study are to describe the generic structure potential, representational meaning, and the context of situation of Rollingstone; February 9th, 2006 edition. The approach of this study is qualitative research and the type is document research. The researcher uses document from the picture of Rollingstone; February 9th, 2006 edition which taken from Rollingstone’s official website. Analysis techniques flow model of this study are collecting the data, displaying and concluding. The results of this study are (1) There are some generic structure potential elements found. They are Lead, LoA, Comp. LoA, Display, Emblem, Announcement, Enhancer, Call and Visit Information and missing one element that is Tag. (2) The representational meaning of this magazine cover by applying narrative process for action process and conceptual representation for symbolic process. (3) The context of situation divided into field, tenor and mode. Field consists of The College Dropout Album, Jesus Walks Songs, 47th Grammy Awards, Rollingstone; February 9th, 2006 edition. Tenor consists of Kanye West as Song Writers, Rollingstone as production house and the target market. The mode consists of the word “The Passion of Kanye West”.
Locutionary act in motivating students at SMPN 2 Wungu
Authors: Santoz Bella Agustina , Ningsih Nuri Ati , Nurhikmawati Agita Risma
Published: June 2019

The aim of this research is to explain the speech act which is used to motivate students at SMPN 2 Wungu. The objective of this research is to explain the type of locutionary act which is used to motivate students. The research approach is qualitative method using observation and interview to collect the data. In this research, the researcher takes three teachers for source of data. Data and method triangulation are used to perform the data validity. Data are analyzed under interactive model. The result of this analysis are there are 26 (52%) utterances that belong to indirect speech act and 24 (48%) utterances belong to direct speech act, thus, it can be concluded that the type which is used to motivate students at SMPN 2 Wungu is indirect speech act.
The use of Learning Management System on University Students’ Vocabulary Mastery
Authors: Novitasari Ifit , Aprianto Eko , Heriyawati Dwi Fita
Published: June 2019

The development of learning media that is interesting and relevant to the education system in Indonesia, although the ability of learners is a barrier today. Various development efforts are always done to complement the process of material oblivion that has been given. Learning methods and learning media are two things that cannot be ignored. Having English skills will add value in the context of human resources. But in an academic environment, English is a foreign language that needs to be mastered not only in communication but also regarding technology and science. The increasingly rapid technological development takes part in the learning development system. Many learning media are used to improve the ability of information or science. Furthermore, this study uses a learning management system (LMS) as one of the technology media to improve students’ vocabulary. The study focuses on the effort to improve vocabulary mastery by using a learning management system. The subjects of this study were the second-semester students from informatics department, Universitas Kanjuruhan Malang. The results of this study show that the students are easier to understand the vocabulary used in technology informatics fields. It can be seen that the results of their average of the final score are 85.00 improved higher than the previous score, before the use of LMS in the teaching vocabulary, the score is 65.00. It is expected that the result of this study can be one of the alternative ways to help students understand vocabulary easily.
Energetic Self-Folding Mechanism in α-Helixes
Authors: Bastida Adolfo , Zúñiga José , Requena Alberto , Cerezo Javier
Published: June 2019

A novel energetic route driving the folding of a polyalanine peptide from an extended conformation to its α-helix native conformation is described, supported by a new method to compute mean potential energy surfaces accurately in terms of the dihedral angles of the peptide chain from extensive Molecular Dynamics simulations. The Energetic Self-Folding (ESF) route arises specifically from the balance between the intrinsic propensity of alanine residues towards the αR conformation and two, opposite, effects: the destabilizing interaction with neighbor residues and the stabilizing formation of native hydrogen bonds, with the latter being dominant for large peptide lengths. The ESF mechanism provides simple but robust support to the nucleation-elongation, or zipper models, and offers a quantitative energetic funnel picture of the folding process. The mechanism is validated by the reasonable agreement between the computed folding energies and the experimental values.
Nano-Folded Gold Electrocatalysts Enhance the Selectivity of Carbon Dioxide Reduction
Authors: Kwok Kam Sang , Wang Yuxuan , Cao Michael , Shen Hao , Xu Weinan , Muller David , Wang Chao , Gracias David
Published: June 2019

The local structure and geometry of catalytic interfaces can influence the selectivity of chemical reactions. Here, using a pre-strained polymer, we uniaxially compress a thin gold film to form a nano-folded catalyst. We observe two kinds of folds and can tune the ratio of loose to tight folds by varying the extent of pre-strain in the polymer. We characterize the nano-folded catalysts using x-ray diffraction, scanning, and transmission electron microscopy. We observe grain reorientation and coarsening in the nano-folded gold catalysts. Electroreduction of carbon dioxide with these nano-folded catalysts reveals an enhancement of Faradaic efficiency for carbon monoxide formation by a factor of about four. This result suggests that electrolyte mass transport limitations and an increase of the local pH in the tight folds of the catalyst outweigh the effects of alterations in grain characteristics. Together, our studies demonstrate that nano-folded geometries can significantly alter grain characteristics, mass transport, and catalytic selectivity.
Accelerated Molecular Dynamics for Structural Prediction in Protein/Peptide Binding: The SLICE Method
Authors: McFarlane James , Krause Katherine , Paci Irina
Published: June 2019

The work in this submission presents a molecular simulation technique that is able to overcome induced-fit binding issues with a uniquely challenging binding site. This method differs from commercially available methods in that we use a combined software approach that allows users to patch together inexpensive and academically available programs. Our method also differs fundamentally in how the potential energy of the interaction is explored and lends itself to the success in modeling our test system. As an added benefit, our test system is CBX8, an epigenetic reader protein and speculative target for chemotherapy. The method was not only successful in matching crystal structure data, but uncovered a number of induced-fit structural features of the binding motif that are useful in the design of potential inhibitors for this protein.
Operando Visualization of Morphological Dynamics in All-Solid-State Batteries
Authors: Wu Xiaohan , Billaud Juliette , Jerjen Iwan , Marone Federica , Ishihara Yuya , Adachi Masaki , Adachi Yoshitaka , Villevieille Claire , Kato Yuki
Published: June 2019

All-solid-state batteries are considered as attractive options for next-generation energy storage owing to the favourable properties (unit transference number and thermal stabilities) of solid electrolytes. However, there are also serious concerns about mechanical deformation of solid electrolytes leading to the degradation of the battery performance. Therefore, understanding the mechanism underlying the electro-mechanical properties in SSBs are essentially important. Here, we show three-dimensional and time-resolved measurements of an all-solid-state cell using synchrotron radiation x-ray tomographic microscopy. We could clearly observe the gradient of the electrochemical reaction and the morphological evolution in the composite layer. Volume expansion/compression of the active material (Sn) was strongly oriented along the thickness of the electrode. While this results in significant deformation (cracking) in the solid electrolyte region, we also find organized cracking patterns depending on the particle size and their arrangements. This study based on operando visualization therefore opens the door towards rational design of particles and electrode morphology for all-solid-state batteries.
Expression of a constitutively active humanSTINGmutant in hematopoietic cells produces anIfnar1-dependent vasculopathy in mice
Authors: Martin Gary R , Henare Kimiora , Salazar Carolina , Scheidl-Yee Teresa , Eggen Laura J , Tailor Pankaj P , Kim Jung Hwan , Podstawka John , Fritzler Marvin J , Kelly Margaret M , Yipp Bryan G , Jirik Frank R
Published: June 2019

STING-associated vasculopathy with onset in infancy (SAVI) is an autoinflammatory disorder characterized by blood vessel occlusions, acral necrosis, myositis, rashes, and pulmonary inflammation that are the result of activating mutations in the STimulator of Interferon Genes (STING). We generated a transgenic line that recapitulates many of the phenotypic aspects of SAVI by targeting the expression of the human STING-N154S–mutant protein to the murine hematopoietic compartment.hSTING-N154Smice demonstrated failure to gain weight, lymphopenia, progressive paw swelling accompanied by inflammatory infiltrates, severe myositis, and ear and tail necrosis. However, no significant lung inflammation was observed. X-ray microscopy imaging revealed vasculopathy characterized by arteriole occlusions and venous thromboses. Type I interferons and proinflammatory mediators were elevated inhSTING-N154Ssera. Importantly, the phenotype was prevented inhSTING-N154Smice lacking the type I interferon receptor gene (Ifnar1). This model, based on a mutant human STING protein, may shed light on the pathophysiological mechanisms operative in SAVI.
Robotic Spot Welding of DOCOL 1200M Steel
Authors: Górka Jacek , Ozgowicz Andrzej , Matusek Kamil
Published: June 2019

The paper presents robotic spot resistance welding technologies for DOCOL 1200M steel with a thickness of 1.8 mm. DOCOL 1200M steel with a martensitic structure is intended mainly for the production of car bumpers, side beams and other elements ensuring the safety of the user of motor vehicles. The test joints were made on a robotic station equipped with a KUKA KR180 robot and a welding from ARO. The obtained welded joints were subjected to macro and microscopic metallographic tests, hardness measurement and strength tests. It has been shown that for properly selected resistance spot welding, DOCOL 1200M steel joints with a satisfactory strength level can be obtained.