bluuebunny/crossref_metadata_2025 huggingface dataset:
Inducing Postactivation Potentiation With Different Modes of Exercise
Authors: Ng Choon Yeow , Chen Siow Ee , Lum Danny
Published: December 2019

The use of various modes of exercise to induce postactivation potentiation (PAP) has been studied in the current literature. However, discussion on the advantages and disadvantages of these multiple modes of exercises in inducing PAP within one review study has not been conducted. A brief discussion on the available findings on the effects of different exercises in inducing PAP is presented in this review. Coaches and athletes should take the available information into consideration because the magnitude of PAP effect may vary depending on the mode of exercise performed.
Os Desafios do Bem-estar na América Latina, as Políticas de Igualdade de Gênero e as Respostas Governamentais para a “Crise do Cuidado”
Authors: Paradis Clarisse
Published: December 2019

Os países latino-americanos enfrentaram profundas transformações sociais e demográficas nos últimos vinte anos, com a incorporação massiva das mulheres no trabalho remunerado, transformações no escopo da família nuclear e o envelhecimento de sua população. Essas transformações geram dilemas associados à relação entre o trabalho remunerado e não remunerado e à “crise do cuidado”. Se houve uma renovação da agenda social entre o início do século e meados da sua segunda década, na América Latina, quais foram as percepções e respostas dos Estados a estas transformações? A partir do aporte da literatura sobre Estados de Bem-Estar Social, suas críticas feministas e adequações para pensar o contexto regional, serão analisados os planos nacionais de igualdade de gênero, com o objetivo de averiguar se e como os governos consideraram, valoraram e propuseram soluções para essas transformações. Conclui-se que para que os sistemas de bem-estar latino-americanos desafiem as desigualdades de gênero é necessário efetivar e fortalecer a participação do Estado na produção do viver.
Optimising glucocorticoid replacement in adrenal insufficiency
Authors: Meeran Karim
Published: December 2019

Several different regimens for steroid replacement have been tried, but head to head studies of different treatments need to be more widely undertaken. Once daily treatment with prednisolone gives the most physiological profile, and studies comparing prednisolone with hydrocortisone are now being undertaken. It is likely that prednisolone 4mg daily will be the optimum treatment used.
Effective Hadronic Supersymmetry from Quantum Chromodynamics
Authors: Catto S. , Gürcan Y. , Nicolescu B. , Yu E.
Published: December 2019

A quark model with potentials derived from QCD that include antiquark-diquark model for excited hadrons leads to mass formulae in very good agreement with experiments. The approximate symmetries and supersymmetries of the hadronic spectrum are exploited including a symmetry breaking mechanism.
Finite-Temperature Bose-Einstein Condensation in Interacting Boson System
Authors: Anchishkin D. , Mishustin I. , Stashko O. , Zhuravel D. , Stoecker H.
Published: December 2019

Thermodynamical properties of an interacting boson system at finite temperatures and zero chemical potential are studied within the framework of the Skyrme-like mean-field toy model. It is assumed that the mean field contains both attractive and repulsive terms. Self-consistency relations between the mean field and thermodynamic functions are derived. It is shown that, for sufficiently strong attractive interactions, this system develops a first-order phase transition via the formation of a Bose condensate. An interesting prediction of the model is that the condensed phase is characterized by a constant total density of particles. It is shown that the energy density exhibits a jump at the critical temperature.
Action-at-a-Distance and Radiation Reaction of Point-Like Particles in de Sitter Space
Authors: Duviryak A. , Yaremko Yu.
Published: December 2019

The two-particle system with the time-asymmetric retarded-advanced electromagnetic interaction known as the Staruszkiewicz–Rudd–Hill model is considered in the de Sitter space-time. The manifestly covariant descriptions of the model within the Lagrangian and Hamiltonian formalisms with constraints are proposed. It is shown that the model is de Sitter-invariant and integrable. An explicit solution of the equations of motion is derived. We use the covariant electromagnetic Green function in the de Sitter space in order to derive the equation of motion of a point charge in an external electromagnetic field, where the radiation reaction is taken into account.
Composite Fermions as Deformed Oscillators: Wavefunctions and Entanglement
Authors: Gavrilik A. M. , Mishchenko Yu. A.
Published: December 2019

Composite structure of particles somewhat modifies their statistics, compared to the pure Bose- or Fermi-ones. The spin-statistics theorem, so, is not valid anymore. Say, п-mesons, excitons, Cooper pairs are not ideal bosons, and, likewise, baryons are not pure fermions. In our preceding papers, we studied bipartite composite boson (i.e. quasiboson) systems via a realization by deformed oscillators. Therein, the interconstituent entanglement characteristics such as entanglement entropy and purity were found in terms of the parameter of deformation. Herein, we perform an analogous study of composite Fermi-type particles, and explore them in two major cases: (i) “boson + fermion” composite fermions (or cofermions, or CFs); (ii) “deformed boson + fermion” CFs. As we show, cofermions in both cases admit only the realization by ordinary fermions. Case (i) is solved explicitly, and admissible wavefunctions are found along with entanglement measures. Case (ii) is treated within few modes both for CFs and constituents. The entanglement entropy and purity of CFs are obtained via the relevant parameters and illustrated graphically.
Symmetries of Relativistic Hydrogen Atom
Authors: Simulik V. M. , Gordievich I. O.
Published: December 2019

The Dirac equation in the external Coulomb field is proved to possess the symmetry determined by 31 operators, which form the 31-dimensional algebra. Two different fermionic realizations of the SO(1,3) algebra of the Lorentz group are found. Two different bosonic realizations of this algebra are found as well. All generators of the above-mentioned algebras commute with the operator of the Dirac equation in an external Coulomb field and, therefore, determine the algebras of invariance of such Dirac equation. Hence, the spin s = (1, 0) Bose symmetry of the Dirac equation for the free spinor field, proved recently in our papers, is extended here for the Dirac equation interacting with an external Coulomb field. A relativistic hydrogen atom is modeled by such Dirac equation. We are able to prove for the relativistic hydrogen atom both the fermionic and bosonic symmetries known from our papers in the case of a non-interacting spinor field. New symmetry operators are found on the basis of new gamma matrix representations of the Clifford and SO(8) algebras, which are known from our recent papers as well. Hidden symmetries were found both in the canonical Foldy–Wouthuysen and covariant Dirac representations. The found symmetry operators, which are pure matrix ones in the Foldy–Wouthuysen representation, become non-local in the Dirac model.
To the Memory of Moisei Isaakovych Kaganov
Authors: Bazaliy Ya. B. , Bakai O. S. , Bar’yakhtar V. G. , Loktev V. M. , Yu Lu
Published: December 2019

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La experiencia estética de la mirada: el ver y oír en la conformación de la palabra tejida en la obra Quipu Mapocho de Cecilia Vicuña
Authors: Bachraty Dagmar Jana
Published: December 2019

El siguiente artículo tiene por objetivo la discusión frente a la existencia de un lenguaje visual como forma de recuperación de una comunicaciónancestral en el mundo del arte, basada en la experiencia de los sentidos. Es por ello, que se plantea la reminiscencia de una memoria no alfabetizada (ideográfica), táctil, auditiva y visual dentro de la cultura andina, la cual por medio de la plástica moderna y performance de Cecilia Vicuña rememora una antigua función nemotécnica que sustituye a la palabra por una imagen. Es decir, una nueva (o antigua) forma de contar y preservar la memoria histórica latinoamericana. Quipu Mapocho, obra presentada por la artista chilena en el Museo Nacional de Bellas Artes de Chile, 2017, constituye una remembranza como soporte histórico a través del uso de la fotografía y la actualización simbólica de un quipu andino y la imagen de un niño ofrendado en una Capacocha. La palabra en este sentido, se vuelve experiencia, imagen y alegoría.*** A experiência estética do olhar: o ver e o ouvir na conformação da alavra tecida na obra Quipu Mapocho, de Cecilia Vicuña ***O presente artigo busca discutir a existencia de uma linguagem visual como forma de recuperação de uma comunicação ancestral no mundo da arte, a qual é baseada na experiência dos sentidos. É diante disso que se estabelece a reminiscência de uma memoria não alfabetizada (ideológica), táctil, auditiva e visual dentro da cultura andina, a qual, por meio de um trabalho plástico e performático de Cecília Vicuña, rememora-se uma antiga função mnemónica que substitui a palavra por uma imagem. Esta é uma nova (ou antiga) forma de contar e preservar a memoria histórica latino-americana. Quipu Mapocho, obra apresentada pela artista chilena no Museu Nacional de Bellas Artes no Chile em 2017, constitui uma lembrança como suporte histórico por meio do uso da fotografía e da atualização simbólica de um quipu andino e a imagen de um menino como uma oferenda à Capacocha. A palabra, nesse contexto, torna-se uma experiencia, uma imagen e uma alegoria. PALAVRAS-CHAVE: Experiência; Quipu Mapocho; Cacilia Viaiña; Imagens históricas
Rememoração da ditadura por meio da fotografia: possíveis representações e leituras de P14311
Authors: Pott Airton
Published: December 2019

A representação e a rememoração de identidades culturais podem ser realizadas de diversas e diferentes formas: escrita histórica, ficcional, teatro, documentários, cinematografia, pinturas, imagens e fotografias. À vista disso, pretendemos analisar algumas fotografias do livro P14311, de Diego Di Niglio, o qual é relacionado ao período da ditadura. Além do mais, no final do livro há um texto de José Afonso Jr, professor e pesquisador de fotografia da Universidade Federal de Pernambuco (UFPE), em que ele explana algumas noções sobre o livro P14311 e a câmera e a fotografia. Diante disso, nossos estudos são fundamentados em um levantamento bibliográfico a partir de conceitos sobre a fotografia, sobretudo, como forma de memória, fundamentados em Barthes (1984), Kossoy (2001), Dubois (1993) e Felizardo e Samain (2007), e também visitamos a fotografia como sendo uma forma discursiva e um lugar de fala, sendo que para isso nos reportamos aos estudos de Foucault (2008), Deleuze (1999) Ribeiro (2017) e Amaral (2005). Enfim, as linhas teóricas que escolhemos e delineamos conforme nossa proposta de investigação nos levam a inúmeras conclusões, dentre as quais destacamos que em P14311 há muita vida por trás da morte, do sofrimento e das separações de famílias nele representadas.
A fotografia como imagem-ficção em Alice in Wonderland, de Suzy Lee
Authors: Girão Luis Carlos
Published: December 2019

O presente escrito visa refletir sobre a escolha da fotografia como elemento constitutivo e potencial da narrativa pictórica em Alice in Wonderland (2002), de Suzy Lee. Em seu primeiro livro-imagem, a book artist sul-coreana utiliza-se da linguagem visual fotográfica para estruturar e registrar jogos de revelação/falsificação em imagens que lampejam incessantes re-presentificações ao clássico da Literatura Infantil escrito por Lewis Carroll. Para refletirmos sobre esse processo de ficcionalização imagético, tomaremos as reflexões de Philippe Dubois (2016, 2017) sobre o conceito de imagem-ficção, vertente esta exponencial no campo da arte-fotografia contemporânea. E para nos auxiliar a pensar sobre o re-posicionamento sensível do olhar proposto por Suzy Lee em seu livro híbrido – entre o literário, plástico, fotográfico –, buscamos em Georges Didi-Huberman (2010, 2013, 2015, 2017) as compreensões de dupla distância e de montagem como limiares que irrompem diante do leitor, criança ou jovem, produzindo estranhamentos ao seu experienciar a aura da obra de arte.
Uso da fotografia em Nove Noites, de Bernardo Carvalho, e Vou lá visitar pastores, de Ruy Duarte de Carvalho
Authors: Souza Daniel Moutinho
Published: December 2019

Este artigo se baseia em formulações teóricas clássicas sobre a fotografia (Barthes, Sontag, Dubois) com o objetivo de estudar comparativamente o uso da fotografia em duas obras contemporâneas. Em Nove noites, o autor brasileiro Bernardo Carvalho (2002) inclui fotografias de alguns de seus personagens e de si próprio para sugerir uma relação problemática entre o enredo ficcional do romance e o “mundo real”; no ensaio Vou lá visitar pastores, do antropólogo angolano Ruy Duarte de Carvalho (2000) faz o oposto: inclui em seu relato etnográfico fotografias tratadas de tal modo que a sua referência na realidade seja posta em questão, em consonância com o estilo de escrita que o aproxima do registro literário. Do fato de que a obra de Ruy Duarte foi comentada e elogiada por Bernardo Carvalho antes do surgimento de Nove noites deriva a hipótese de que a presença das fotografias nessas obras, com caráter ao mesmo tempo oposto e complementar, não seja uma coincidência.
Poéticas interartísticas: nos limiares da criação literária
Authors: Borges Fernanda
Published: December 2019

A confluência entre as linguagens visual e verbal e o hibridismo dos textos no contato entre palavra e imagem representam uma perspectiva que vem sendo redescoberta nos estudos literários e culturais. Esse diálogo, por mais inovador que pareça ser, não é uma novidade no campo das artes de um modo geral e nem mesmo no campo da literatura visto que, ante uma perspectiva histórica, os limiares artísticos fazem parte da história do conhecimento e da arte. A partir de obras compostas por artigos de jornal, desenhos, fotografias, mapas e por uma disposição textual peculiar ultrapassam a concepção tradicional do que se entende como romance, por exemplo, ao incorporarem, sobretudo, outras manifestações artísticas, o que permite que sejam denominadas como narrativas híbridas e interartísticas, este artigo pretende refletir acerca desse movimento escritural plural e heterogêneo.
Escrever-se, fotografar-se: convergências entre Vivian Maier e Ana Cristina Cesar
Authors: Pasinato Izumino Julia
Published: December 2019

Procurando desenvolver uma análise das “afinidades eletivas entre a Fotografia e a Poesia” (NAVAS, 2017), atentamos para as convergências e divergências mapeáveis entre os autorretratos fotográficos da estadunidense Vivian Maier e a poesia mista de prosa, diário e correspondência íntima da brasileira Ana Cristina Cesar, buscando compreender como se dão os procedimentos de construção do sujeito ficcional trabalhados dentro da própria lógica dos gêneros autobiográficos e autorrepresentativos. Neste artigo, analisando especificamente a forma como ambas as artistas incorporam os gestos criativos – isto é, a encenação do ato de escrever e do ato de fotografar – aos seus textos e imagens, os mecanismos de interlocução e figuração do Outro e de seus próprios corpos.
Entre documento e ficção: fotorrelatos na Espanha da década de 1960
Authors: Vieira Elisa Maria Amorim
Published: December 2019

O principal objetivo deste trabalho é analisar o ressurgimento do gênero costumbrista na Espanha da década de 1960, quando relatos de cenas do cotidiano e retratos de tipos urbanos passaram a ser acompanhados de fotografias-documento. Nesse período, a relação entre texto literário e fotografia foi amplamente cultivada através da publicação de uma série de fotolivros, tanto na Espanha quanto na América Latina. O corpus principal desta pesquisa é o fotolivro Nuevas escenas matritenses, que reúne fotografias de Enrique Palazuelo e textos de Camilo José Cela, no qual a aproximação entre palavra e imagem ora potencializa o processo de fabulação, ora gera tensão entre os dois meios. Para a realização dessa análise, recorreu-se às reflexões de Joan Fontcuberta e André Rouillé sobre os limites e o poder transformador do realismo fotográfico, assim como às observações de Christoph Rodiek sobre a obra de Camilo José Cela e às de Karl Erik Schøllhammer sobre a relação entre palavra e imagem.
Efecto del ácido indolbutírico (AIB), pyraclostrobin (F-500) y un inoculante biológico sobre el enraizamiento y crecimiento inicial de estaquillas de tres híbridos f1 de café (Coffea arabica)
Authors: Sosa Mora Carolina , Mesén Sequeira Francisco , Jiménez Alvarado Luis Diego
Published: December 2019

En el Centro Agronómico Tropical de Investigación y Enseñanza, CATIE se utiliza la técnica de enraizamiento de estaquillas para la multiplicación de híbridos de café en corto tiempo y a bajo costo. En la búsqueda continua por mejorar el proceso, en este trabajo se evaluó el efecto de distintas combinaciones de AIB, un inoculante biológico y Pyraclostrobin (F 500), más un tratamiento convencional de nutrientes y estimuladores sobre el enraizamiento de estaquillas de 3 híbridos F1 de café (L2A30, L4A5, L12A28) y su posterior desarrollo en vivero. La fase de enraizamiento se prolongó por 11 semanas, y al final de este periodo, no hubo diferencias significativas en porcentaje de enraizamiento entre tratamientos ni entre híbridos, con porcentajes superiores al 80% en todos los casos. Tampoco hubo diferencias significativas entre tratamientos para las variables de número, longitud de raíces ni pesos de parte aérea y raíces. Los híbridos L2A30 y L12A28 fueron significativamente superiores al L4A5, en cuanto a número y longitud de raíces, peso fresco y seco de raíces y parte aérea. Las estaquillas fueron trasplantadas luego a bolsas con suelo para la fase de vivero, para un periodo de crecimiento de 3 meses. Al final de esta fase, el tratamiento convencional y las combinaciones AIB + inoculante biológico y AIB + Pyraclostrobin (F 500) fueron superiores significativamente en cuanto a altura de planta y número de hojas. Los híbridos L4A5 y L2A30 fueron superiores significativamente al L12A28 en cuanto a altura total y número de hojas, mientras que el L2A30 y el L12A28, mostraron mayor diámetro basal que el L4A5. Se logró la multiplicación de los híbridos seleccionados a escala masiva y a bajo costo.
Investigation of sphingosin-1-phosphate-triggered matriptase activation using a rat primary hepatocyte model
Authors: Barna Réka Fanni , Pomothy Judit Mercédesz , Paréj Zsuzsanna , Pásztiné Gere Erzsébet
Published: December 2019

Sphingosine-1-phosphate (S1P) has been reported as a matriptase activator. The aim of this study was to reveal if S1P can influence hepcidin production. Furthermore, we investigated how S1P can affect the viability and the redox status of primary hepatocytes. Rat primary hepatocytes were cultivated for 72 h and were treated with 50, 200, 1000 ng/ml S1P. Cell-free supernatants were collected every 24 h. Cell viability was tested by a colorimetric method using tetrazolium compound (MTS). The hepcidin levels in the cell-free supernatants were examined with hepcidin sandwich ELISA to determine the effect of S1P on the hepcidin-modulating ability of matriptase. In order to estimate the extent of S1P-generated oxidative stress, extracellular H2O2 measurements were performed by the use of fluorescent dye. Based on the findings, S1P treatment did not cause cell death for 72 h at concentrations up to 1000 ng/ml. S1P did not influence the extracellular H2O2 production for 72 h. The hepcidin levels were significantly suppressed in hepatocytes exposed to S1P treatment. Further studies would be needed to explore the exact mechanism of action of S1P.
Keleti vallási motívumok a korai magyarsággal kapcsolatba hozható régészeti kultúrákban
Authors: Klima L
Published: December 2019

A tanulmány a Szubotci-horizonthoz tartozó szubotci, katyerinovkai és novonyikolajevkai veretek, valamint a dél-uráli isimbaji, a felső-kámai redikori lelőhelyről származó veretek és a Verhnyij Szaltov, Bolsije Tyigani temetőiből ismert párhuzamaik képi motívumainak eredetét kutatja történeti forrásokra, folklorisztikai és vallástörténeti adatokra támaszkodva.
Absorption, Mentalizing, and Mysticism
Authors: Coleman III Thomas J. , Bartlett James E. , Holcombe Jenny M. , Swanson Sally B. , Atkinson Andrew , Silver Christopher F. , Hood Ralph W.
Published: December 2019

Research suggests trait absorption, individual differences in Theoryof Mind (ToM), and orthopraxical training are importantfor explaining a variety of extraordinary experiences typicallyassociated with religion. However, no studies exist quantifyingToM ability or testing its relationship with trait absorption inthe prediction of what is arguably the most ubiquitous type ofextraordinary experience-the mystical experience. To addressthis, two exploratory studies were conducted using a sample ofmeditators (N = 269) and undergraduate students (N = 123). Instudy one, regression analyses revealed weekly religious/spiritualpractice, absorption, and mentalizing predict increased mysticalexperiences. Moreover, moderation analysis indicated theabsorption-mysticism relationship is stronger among individualswith lower mentalizing ability. Study two only replicated therelationship of absorption and weekly practice with mysticism.These studies highlight the robust contribution of absorption inmystical experiences and suggest a more dynamic role for mentalizingthan is accounted for in the current literature.
Real-Space Approach for the Electronic Calculation of Twisted Bilayer Graphene Using the Orthogonal Polynomial Technique
Authors: Le Hoang Anh , Nguyen Van Thuong , Nguyen Van Duy , Do Van-Nam , Ho Si Ta
Published: December 2019

We discuss technical issues involving the implementation of a computational method for the electronic structure of material systems of arbitrary atomic arrangement. The method is based on the analysis of time evolution of electron states in the real lattice space. The Chebyshev polynomials of the first kind are used to approximate the time evolution operator.  We demonstrate that the developed method is powerful and efficient since the computational scaling law is linear. We invoked the method to study the electronic properties of special twisted bilayer graphene whose atomic structure is quasi-crystalline. We show the density of states of an electron in this graphene system as well as the variation of the associated time auto-correlation function. We find the fluctuation of electron density on the lattice nodes forming a typical pattern closely related to the typical atomic pattern of the quasi-crystalline bilayer graphene configuration.
PREPARATION AND PROPERTIES OF MURINE ANTI-IDIOTYPIC MONOCLONAL ANTIBODIES RECOGNIZING PRIMARY RABBIT POLYCLONAL ANTIBODIES AGAINST MORPHINE DERIVATIVES
Authors: Trofimov A. V. , Ischenko A. M. , Rak A. Ya. , Sergeeva V. E. , Simbirtsev A. S. , Gamaleya N. B. , Berzina A. G. , Stankova N. V. , Ulyanova L. I. , Klimova T. A.
Published: December 2019

Anti-idiotypic antibodies (Ab2), according to the network theory of Jerne, are second-generation immunoglobulins that are produced against the idiotype of an antibody to a specific antigen. Despite the large number of works devoted to the study of the properties of these proteins, their role in the regulation of the immune system is not fully known. It may consist in maintaining or blocking a minimal immune response to the antigen. The study of Ab2 is of great practical and scientific importance. The special properties of Ab2, namely, the ability to partially reproduce the structure of the primary antigen and, upon immunization, induce the appearance of tertiary antibodies, which, like first-generation antibodies, can bind to the antigen, have found application in the development of Ab2-based vaccines, in particular, for the treatment of tumors. In view of the presence of a number of limitations on research related to psychoactive substances, the development of Ab2- based vaccines against drug addiction also seems promising. To example, anti-idiotypic antibodies obtained for this purpose possessing a cocaine-like structure are described in the literature. In this work, murine monoclonal anti-idiotypic antibodies (mAb2) mimicking the structure of various morphine derivatives were obtained. Rabbit polyclonal antibodies to the 6-hemisuccinyl derivative of morphine conjugated with bovine serum albumin isolated by affinity chromatography were used as primary antibodies for immunization. Four hybridoma clones were obtained as a result of the fusion of immunized mice lymphocytes with mouse Sp2/0 mouse myeloma cells by the Milstein-Köhler method. After growth in animals, mAb2 produced by hybridoma cells were affinity purified. We investigated the physicochemical and antigenic properties of the isolated antibodies. It was shown that the obtained mAb2 differ in immunological specificity, competing in different degree with morphine derivatives for binding to first-generation antibodies. We tested the possibility of using the obtained mAb2 as antigen analogues in the solid-phase enzyme-linked immunosorbent assay to determine the titer of primary antibodies against morphine in the blood serum of laboratory animals immunized with morphine derivatives. Based on the obtained anti-idiotypic antibodies, it is proposed to develop test systems to determine the serum opiate-specific antibodies in people after specific vaccination for therapeutic or prophylactic purposes to avoid the use of drugs as antigens immobilized on the solid phase in the analysis.
Correction to: Propagation of reinforcement corrosion: principles, testing and modelling
Authors: Andrade Carmen
Published: December 2019

The article Propagation of reinforcement corrosion: principles, testing and modelling, written by Carmen Andrade, was originally published electronically on the publisher’s internet portal (currently SpringerLink) on 26 December 2018 without open access.
Molecular Analyses of Left- and Right-Sided Tumors in Adolescents and Young Adults with Colorectal Cancer
Authors: Salem Mohamed E. , Battaglin Francesca , Goldberg Richard M. , Puccini Alberto , Shields Anthony F. , Arguello David , Korn W. Michael , Marshall John L. , Grothey Axel , Lenz Heinz-Josef
Published: December 2019

Background

The incidence of colorectal cancer (CRC), particularly left-sided tumors (LT), in adolescents and young adults (AYA) is rising. Epigenetic events appear to play an important role in tumorigenesis and cancer progression, especially in younger patients. We compared molecular features of LT to right-sided tumors (RT) in AYA.

Materials and Methods

A total of 246 LT and 56 RT were identified in a cohort of 612 AYA with primary CRC. Tumors were examined by next-generation sequencing (NGS), protein expression, and gene amplification. Tumor mutational burden (TMB) and microsatellite instability (MSI) were determined based on NGS data.

Results

RT showed higher mutation rates compared with LT in several genes including BRAF (10.3% vs. 2.8%), KRAS (64.1% vs. 45.5%), PIK3CA (27% vs. 11.2%), and RNF43 (24.2% vs. 2.9%). Notably, additional mutations in distinct genes involved in histone modification and chromatin remodeling, as well as genes associated with DNA repair and cancer-predisposing syndromes, were characteristic of RT; most frequently KMT2D (27.8% vs. 3.4%), ARID1A (53.3% vs. 21.4%), MSH6 (11.1% vs. 2.3%), MLH1 (10.5% vs. 2.3%), MSH2 (10.5% vs. 1.2%), POLE (5.9% vs. 0.6%), PTEN (10.8% vs. 2.3%), and BRCA1 (5.4% vs. 0.6%). MSI was seen in 20.8% of RT versus 4.8% of LT. RT had a higher frequency of TMB-high regardless of MSI status.

Conclusion

Molecular profiling of AYA CRC revealed different molecular characteristics in RT versus LT. Epigenetic mechanisms and alteration in DNA repair genes warrant further investigation and may be a promising treatment target for CRC in AYA.

Implications for Practice

Colorectal cancer (CRC) in adolescents and young adults (AYA) comprises a distinct entity with different clinicopathologic features and prognosis compared with older patients. Molecular profiling of right- and left-sided tumors in AYA is needed to gain novel insight into CRC biology and to tailor targeted treatment in this age group. This study found that right- and left-sided CRC show distinct molecular features in AYA, overall and in subgroups based on microsatellite instability status. Alterations in DNA double-strand break repair and homologous recombination repair, as well as epigenetic mechanisms, appear to play a critical role. The present molecular profiling data may support the development of personalized treatment strategies in the AYA population.
Anisotropic small-strain stiffness of calcareous sand affected by sample preparation, particle characteristic and gradation
Authors: Shi Jinquan , Haegeman Wim , Cnudde Veerle
Published: December 2019

Sands exhibit a directional diversity in shear modulus at small strains, reflecting the anisotropic stiffness behaviour in the structure. In this paper, sample preparation method, particle shape and particle size are considered as parameters to produce samples with various initial fabric. Five preparation methods, namely, air and water pluviation, dry and moist tamping and dry funnel deposition are used to reconstitute the samples. The stiffness anisotropy of calcareous sand and Mol silica sand is quantified by the small-strain modulus G0 measured in horizontal and vertical planes with the bender element technique in triaxial tests. Test results show that calcareous sands behave as an elastic homogeneous continuum material at small strains. Calcareous samples prepared by the air pluviation method possess the highest anisotropic ratios. The lowest stiffness anisotropy exists in the samples prepared by moist tamping and dry funnel deposition methods. Compared with the anisotropic ratios of the air pluviation samples from the literature, the notably higher values for the calcareous sand in this study are attributed to the lower sphericity. In addition, less prominent stiffness anisotropy is found in calcareous sands with smaller particle sizes (D50).
The Propagation of Demand Shocks Through Housing Markets
Authors: Anenberg Elliot , Ringo Daniel
Published: December 2019

Housing demand stimulus produces a multiplier effect by freeing up owners attempting to sell their current home, allowing them to re-enter the market as buyers and triggering a chain of further transactions. Exploiting a shock to first-time home buyer demand caused by the 2015 surprise cut in Federal Housing Administration mortgage insurance premiums, we find that homeowners buy their next home sooner when the probability of their current home selling increases. This effect is especially pronounced in cold housing markets, in which homes take a long time to sell. We build and calibrate a model of the joint buyer-seller search decision that explains these findings as a result of homeowners avoiding the cost of owning two homes simultaneously. Simulations of the model demonstrate that stimulus to home buying generates a substantial multiplier effect, particularly in cold housing markets.
Beyond categorical imperatives
Authors: Parker Richard
Published: December 2019

n/a
On the coloniality of global public health
Authors: Richardson Eugene T.
Published: December 2019

The continued inordinate demise from communicable pathogens in the global South is not the result of an intractable problem thwarting our best efforts to prevent and cure disease; we have the means. Rather, as an accomplice to contemporary imperialism, public health manages (as a profession) and maintains (as an academic discipline) global health inequity. It does this through ‘bourgeois empiricist’ models of disease causation, which serve protected affluence by uncritically reifying inequitable social relations in the modern/colonial matrix of power and making them appear commonsensical.
BÜYÜK VE ORTA BOY İŞLETMELER İÇİN FİNANSAL RAPORLAMA STANDARDI (BOBİ FRS): MUHASEBE UYGULAYICILARINA YÖNELİK BİR ARAŞTIRMA
Authors: ERGİ Şener , GÜLEÇ Ömer Faruk
Published: December 2019

Mali
tabloların ihtiyaca uygun, karşılaştırılabilir ve güvenilir bir şekilde
hazırlanması ve raporlamada dil birliğinin sağlanmasında finansal raporlama
standartları daha önemli hale getirmiştir. Başta Avrupa ülkeleri olmak üzere
birçok ülkede Uluslararası Finansal Raporlama
Standartları (UFRS) seti ve yerel finansal raporlama standartları
kullanılmaktadır. Bu doğrultuda, Türkiye’de bağımsız denetime tabi
işletmelerden, Türkiye Finansal Raporlama Standartları’nı (TFRS) uygulamayanlar
için yerel bir finansal raporlama seti ihtiyacı ortaya çıkmıştır. Bu amaçla, 29
Temmuz 2017 tarihinde 30138 Sayılı Tebliğ ile Büyük ve Orta Boy İşletmeler İçin
Finansal Raporlama Seti (BOBİ FRS) yayınlanmış ve 1 Ocak 2018’de yürürlüğe
girmiştir. Bu çalışmanın temel amacı, BOBİ FRS’nin gelişim sürecini ele alarak
muhasebe uygulayıcılarının BOBİ FRS hakkındaki görüş ve düşüncelerini tespit
etmektir. Bu kapsamda literatürden yararlanılarak anket formu oluşturulmuş ve
283 adet geçerli örneklem sayısına ulaşılmıştır. Araştırmada kullanılan anket 2
bölümden oluşmaktadır. Birinci bölümde muhasebe uygulayıcılarının BOBİ FRS’ye
yönelik görüş ve düşüncelerini ölçmek için katılımcılara 30 tane 5’li likert
tipi ifade sorusu yöneltilmiştir. Anketin ikinci bölümünde ise demografik
sorular ve BOBİ FRS’ye yönelik 7 tane genel soru yer almaktadır.
Economic Education of School Students: Causes of the Crisis
Authors: Mikheeva Svetlana , Zhurkina Olga
Published: December 2019

Russia’s national school curriculum standards stipulate economic education at three levels: basic, advanced, and as part of the social theory course, yet schools rarely include basic economics in their curricula. Curricula of 615 St. Petersburg schools available at their official websites as well as data from online surveys of parents, students, teachers, and school administrators are used to find evidence of the demand for economics as a subject among school students. The fact that only two levels of economics instruction are represented in St. Petersburg schools is explained by staffing issues and impossibility to take the Unified State Exam (USE) in economics. Initiatives for a meaningful change the current situation are proposed in the article.
The Guided Inquiry to Improve Students Mathematical Critical Thinking Skills Using Student’s Worksheet
Authors: YASİN Muhamad , JAUHARİYAH Durrul , MADİYO Madiyo , RAHMAWATİ Rika , FARİD Fajri , IRWANDANİ İrwandani , MARDANA Frendy Fitra
Published: December 2019

In this study, research using guided inquiry was conducted to improve students' ability to think critically. By improving and making the worksheets the students of this research are expected to make it easier to understand a lesson. The development step in this study is to conduct a preliminary study as the first stage, then pre-product planning and development, after which the pretest, product pre-revision and field test are carried out. Data collected in this study was carried out by observation, documentation, interviews, questionnaires and tests. In addition, student worksheets are validated based on media and material, which will be given revisions based on suggestions from the media, matrices, and experts. The participants of this study were students Junior High School of SMP Negeri 30 Bandar Lampung, Indonesia. The final results in this study, showed that the development of guided inquiry based worksheets was able to improve students' critical thinking power, which was obtained from the results of good category values, namely 71.07% on average students in mathematical critical thinking.
Food4Gut multicenter randomized placebo-controlled trial. v1
Authors: Hiel Sophie , A. Gianfrancesco Marco , Rodriguez Julie , Portheault Daphnée , Leyrolle Quentin , B. Bindels Laure , Gomes da Silveira Cauduro Carolina , D.G.H. Mulders Maria , Zamariola Giorgia , Azzi Anne-Sophie , Kalala Gaetan , D. Pachikian Barbara , Amadieu Camille , M. Neyrinck Audrey , Loumaye Audrey , D. Cani Patrice , Lanthier Nicolas , Trefois Pierre , Klein Olivier , Luminet Olivier , Bindelle Jérôme , Paquot Nicolas , Cnop Miriam , Thissen Jean-Paul , M. Delzenne Nathalie
Published: December 2019

Objectives:We describe the methodology of a trial designed to highlight the interest of vegetables rich in ITF-prebiotics in obese adults. DESIGN:150 obese subjects (BMI> 30 kg.m-2; 18–65 years) recruited in three different university hospitals in Belgium will be selected with at least one of the following criteria: (pre-)diabetes, hypertension, dyslipidemia, liver steatosis. They will be randomly assigned to receive either 16 g/day of inulin (Fibruline, Cosucra) with dietary advice to promote the consumption of vegetables rich in ITF or 16 g/day placebo (maltodextrin, Cargill) with dietary advice provided nutrients to promote the consumption of vegetables poor in ITF for 3 months. Review of literature, analysis of ITF content in vegetables and satisfaction and digestive tolerance tests (on healthy volunteers) will be performed to propose adequate receipts. Results: The primary outcome is to evaluate the impact of a higher consumption of ITF-prebiotics on the gut microbiota composition. The secondary outcome of this trial was the effect of the prebiotic intervention on the BMI. Other secondary endpoints were anthropometric and clinical parameters. Conclusions:The goal of this intervention study is to establish the proof of concept that nutrients which selectively stimulate the growth of beneficial bacteria in the human colon might offer protection against metabolic disorders associated to obesity on an adequate target population.
The New Advertisers: How Foundation Funding Impacts Journalism
Authors: Ferrucci Patrick , Nelson Jacob L.
Published: December 2019

Many journalism stakeholders have begun looking to philanthropic foundations to help newsrooms find economic sustainability. The rapidly expanding role of foundations as a revenue source for news publishers raises an important question: How do foundations exercise their influence over the newsrooms they fund? Using the hierarchy of influence model, this study utilizes more than 40 interviews with journalists at digitally native nonprofit news organizations and employees from foundations that fund nonprofit journalism to better understand the impact of foundation funding on journalistic practice. Drawing on previous scholarship exploring extra-media influence on the news industry, we argue that the impact of foundations on journalism parallels that of advertisers throughout the 20th century—with one important distinction: Journalism practitioners and researchers have long forbidden the influence from advertisers on editorial decisions, seeing the blurring of the two as inherently unethical. Outside funding from foundations, on the other hand, is often premised on editorial influence, complicating efforts by journalists to maintain the firewall between news revenue and production.
Anti-cancer activity of сuraxin CBL0137 on the models of acute leukemia in vitro
Authors: Fetisov T. I. , Kirsanov K. I. , Borunova A. A. , Zatsepina M. N. , Lesovaya E. A. , Zabotina T. N. , Belitsky G. A. , Yakubovskaya M. G.
Published: December 2019

Background. Curaxin CBL0137 is a novel non-genotoxic compound with anti-cancer activity based on CBL0137 ability of non-covalent interaction with DNA causing histone chaperone FACT relocation. Anti-cancer activity of this drug was demonstrated previously on the wide panel of solid cancer models in vitro and in vivo.

Objectives. Estimation of anticancer effects of CBL0137 on the acute myeloblastic leukemia cells (THP-1) and acute lymphoblastic leukemia (CCRF-CEM).

Materials and methods. CBL0137 cytotoxicity was analyzed using the MTT test, the effects on the cell cycle and the induction of apoptosis was assessed by flow cytometry, the activity of signaling pathways in cells treated with CBL0137 was determined by real-time polymerase chain reaction.

Results. Cell treatment with CBL0137 led to cell cycle arrest and apoptosis induction. In the study of CBL0137 effect on target gene clusters of 10 signal transduction pathways involved in the pathogenesis of acute leukemia we have showed that CBL0137 inhibited the expression of down-stream genes of WNT and Hedgehog signaling in both cell lines. In THP-1 cells we also observed the inhibition of the expression of PPARγ target and hypoxia-activated genes. In CCRF-CEM cells CBL0137 also induced the expression of Notch signaling target genes.

Conclusion. The antitumor activity of CBL0137 was demonstrated on acute leukemia cell cultures, the drug possesses cytotoxicity, causes cell cycle arrest and activation of apoptosis. Significant changes in the expression of efferent gene clusters of several signaling pathways were observed in the cells treated with CBL0137.
New approaches in 3D modeling of in vitro growth of primary cultures of malignant gliomas
Authors: Khochenkova Yu. A. , Dyrda I. G. , Machkova Yu. S. , Solomko E. Sh. , Sidorova T. A. , Khochenkov D. A. , Avilova E. A.
Published: December 2019

Background. The incidence of brain gliomas firmly occupies a leading position among all central nervous system tumors – 40–50 % of the cases detected, more than half of them are glioblastoma. Existing cell lines and cultivation methods do not reflect all the features of the three-dimensional (3D) organization of native glioblastoma. The use of temozolomide leads to the development of drug resistance and acute relapse, followed by a poor clinical outcome. The development of resistance is largely associated with the presence of tumor stem cells in the population and intratumoral heterogeneity. Obtaining 3D cultures from the primary material will allow us to save the stem cell pool and tumor-specific features.

The study objective. Get a 3D model based on primary cell cultures, which allows you to save a heterogeneous population and the original phenotype of tumor cells.

Materials and methods. We used U-87MG human glioma cells and GBM002 primary cell culture obtained from surgical material with a confirmed diagnosis of glioblastoma. Neurospheres were obtained from cell lines, the growth of which was monitored using the InCell Analyzer 6000 automatic cell analysis system. Flow cytometry was used to determine the CD133+ cell content. The expression of the receptor tyrosine kinases VEGFR1, VEGFR2 (endothelial growth factor type 1 and 2 receptors), FGFR2 (fibroblast growth factor receptor type 2) and the hypoxia marker HIF-1α (hypoxia inducible factor, 1α) in the neurospheres was evaluated using confocal microscopy.

Results. GBM002 glioblastoma cells isolated from the surgical material formed neurospheres, while the number of CD133+ cells increased from 1–2 to 16–19 % compared with two-dimensional cultures. During long-term cultivation of cells with non-cytotoxic doses of temozolomide, it was found that such cells form smaller neurospheres compared to control cells. It was shown that the expression of receptor tyrosine kinases during cultivation of GBM002 glioblastoma cells in neurospheres differs from that in two-dimensional cultures. We found that in neurospheres, the expression of FGFR2 and VEGFR1, is significantly increased.

Conclusion. 3D cultivation of primary cultures allows one to obtain a more heterogeneous population of tumor cells that reflects the spatial heterogeneity of cells, increase the pool of stem cells and recreate hypoxia conditions inside the brain micro-tumors.
Pengaruh Struktur Modal dan Ukuran Perusahaan Terhadap Profitabilitas Perusahaan Indonesia (Studi Pada Perusahaan Sektor Properti dan Real Estate yang Listing di BEI Periode 2012-2014)
Authors: Astivasari Novita , Siswanto Ely
Published: December 2019

Penelitian ini bertujuan untuk mengetahui kondisi struktur modal, firm size dan profitabilitas pada perusahaan sektor properti dan real estate yang listing di BEI periode 2012-2014. Serta untuk mengetahui pengaruh struktur modal terhadap profitabilitas yang dimoderasi oleh firm size. Populasi penelitian ini ialah 45 perusahaan sektor properti dan real estate yang listing di BEI 2012-2014. Sampel yang diambil sebanyak 36 perusahaan dengan teknik pengambilan sampel purposive sampling. Teknik analisis yang digunakan dalam penelitian ini adalah regresi linear sederhana dan regresi moderasi menggunakan uji interaksi. Hasil dari penelitian ini menunjukkan bahwa struktur modal berpengaruh positif signifikan terhadap profitabilitas dan firm size tidak memoderasi pengaruh struktur modal terhadap profitabilitas.
Activity profile between winners and losers among female exponents in international silat olahraga competition
Authors: Pawista J An , Saphie Mohamad Nizam Mohamed
Published: December 2019

Aim: The purpose of this study was to determine the details of activity that occurred during the match time between winners and losers among female exponents on Southeast Asian (SEA) Games 2017 silat olahraga competition. Methodology: Twenty female exponents from ten matches (n = 10) of silat olahraga on SEA Games 2017 were selected in this study. The notational analysis focused on fourteen different types of motion categories in silat olahraga: kick, punch, sweep, topple, block, catch, evade/dodge, block and kick, block and punch, block and sweep, fake kick, fake punch, self-release and others. The motion categories were divided into three outcomes, which were Hit Target (HT), Hit Elsewhere (HE) and Missing Opponent (MO). Matched paired t-tests were used to compare differences between winners and losers. Results: There were no significant differences in the activity profiles between winners and losers except for evade/dodge (p = 0.03), but there were significant differences in action outcomes in HT (p = 0.000) and MO (p = 0.025). This study showed that during the match the 51% of the actions were kicks, punches and sweeps. The results also showed that female exponents frequently used lower limbs to attack the opponents. Conclusion: The losers performed less HT actions and higher MO actions compared to the winners. The winners performed more successful actions than the losers during silat matches.
What happens during a teaching-learning process of martial arts and combat sports with novice – A case-study focused on the joint activity organization analysis
Authors: Avelar-Rosa Bruno , López-Ros Víctor
Published: December 2019

Semiotic devices are relevant tools to study the teaching-learning process according to the constructivist perspective, which supports several of the game-centered approach models. Even not being included in the generality of these models, martial arts and combat sports have a clear potential to be developed according to these models. Following this, it was settled a didactic sequence based on the fighting knowledge development through the learning of a striking and a throwing skill. A pragmatic discourse analysis was made and specific forms of joint activity organization, called segments of interactivity, were identified. Inside these segments, several patterns were registered considering their main function and format of interaction. The segments of interactivity of activity organization and guided practice constituted both the bigger part of the time and total number of segments, which suggest that the learning processes should be understood inside of their scope. This way, looking for the activity organization, the predominance of the patterns related with “execution” evolve according with the appropriation of the contents, while the “function” patterns seem to be more relevant when it is proposed a new or more complex task. By the other hand, the results related to guided practice segments remark the importance of the one-to-one interactions between the teacher and the apprentice within the whole classes situation. These results show the singularity of every teaching-learning process in terms of the progressive transfer of control and responsibility from the teacher to the apprentice and the simultaneous establishment of an increasingly rich network of shared meanings between these agents.