bluuebunny/crossref_metadata_2025 huggingface dataset:
OPTIMIZATION AND EVALUATION THE EFFECTIVENESS OF IMMEDIATE PROSTHETIC APPROACHES FOR PATIENTS AFTER TEETH EXTRACTION AND MAXILLOFACIAL SURGERY
Authors: Guskov Alexander V. , Oleynikov Aleksandr A. , Zhukovets Dmitry G. , Levashov Nikita E. , Vasileva Tatiana A.
Published: December 2023

Surgical interventions in the dentoalveolar system and maxillofacial area inevitably lead to the formation of long-term healing postoperative wounds or acquired jaw defects. An accessible method of choice for early rehabilitation is considered to be direct removable dentures, however, traditional approaches to this type of treatment can lead to postoperative inflammatory complications. At the Department of Orthopedic Dentistry and Orthodontics of Ryazan State Medical University carried out orthopedic treatment in 120 patients aged from 21 to 89 years after teeth extraction and surgical interventions in the maxillofacial area during the period from 2021 to 2023. The proposed approach to treatment was to manufacture structures of immediate dentures depending on the type of oral mucosa of the prosthetic bed using additive manufacturing technologies and the creation of elastic elements of dentures bases with dynamic control of inflammatory postoperative complications using an improved Schiller-Pisarev test. The effectiveness of the proposed approach was compared with the traditional immediate dentures. According to the results of the study, it was found that the proposed protocol for treatment and diagnosis made it possible to achieve a reduction in the area of wound healing by 50% and a decrease in the area of inflammation by 78% faster compared to the traditional method. Normalization of the microcirculatory activity of the wound healing zones was achieved in the period from 10 to 20 days of observation, with the traditional method, insufficient microcirculatory activity was noted by the 30th day of observation.
ELECTRICAL CONDUCTIVITY OF HUMAN TOOTH ENAMEL AFTER EXPOSURE TO CHEMICAL OR PHYSICAL FACTORS WHEN FIXING ELEMENTS OF A MULTIBONDING
Authors: Ippolitov Yuri A. , Mikhailova Svetlana A. , Ippolitov Ivan Yu. , Aleshina Elena O. , Gylov Aleksey V. , Mahmoudi Abbas A. , Solаiman Maher A. , Kuralesina Viktoria P.
Published: December 2023

When using multibonding fixed orthodontic equipment, complications are possible mainly associated with the occurrence of tooth enamel caries, despite the presence of a large selection of means for the prevention of dental diseases. During the complex treatment of patients with dental deformities, 2 clinical groups were identified and the enamel surface was treated with 37% orthophosphoric acid and an erbium dental laser with a wavelength of 2940nm - (power 2 W, water 20%, air 75%, tip: BOOST with nozzle H 6/8, laser beam perpendicular to the enamel at a distance of 5 mm from its surface), before fixing the removable bracket element with orthodontic glue (A16.07.048).

The conducted studies have shown that after laser preparation in the etching of enamel with acid, the surface acquires roughness, unevenness with the exposure of numerous micropores, in particular the mouths of enamel channels, which increases the electrical conductivity of enamel and electrometric indicators reach 1.3(0.9; 1.5) mkA from the initial 0.15(0.1;0.2)mkA, whereas after processing the enamel with high-intensity laser light, these values were 0.3 (0.1; 0.4) mkA from the initial 0.15 (0.1; 0.2)mkA, due to the mineral saturation of the interstitial spaces of enamel, the mouths of enamel channels sealed with an organo-mineral complex, which reduces the possibility of its subsurface microbial demineralization.
STUDY OF CLINICAL AND MICROBIOLOGICAL PARAMETERS IN PATIENTS WITH NON-REMOVABLE ORTHODONTIC EQUIPMENT DURING THE USE OF DENTAL GELS IN A COMPARATIVE ASPECT
Authors: Lesteva Anastasia G. , Firsova Irina V. , Strusovskaya Olga G.
Published: December 2023

Inflammatory periodontal disease is the second most common pathology after dental caries, affecting up to 95% of the population of different age groups. The main etiological factor in the occurrence of this pathology is periodontopathogenic microflora. During orthodontic intervention, there is an exacerbation of inflammatory processes in the periodontium due to the accumulation of microbial biofilm, due to the appearance in the oral cavity of patients of additional retention sites in the form of fixed structures. The use of conventional hygiene products is not enough to eliminate deposits of microbial origin. Therefore, to reduce the inflammatory process in the periodontium during orthodontic intervention, it is necessary to use additional hygiene products that provide an adequate antimicrobial effect. These funds should mainly have a specific effect on the periodontopathogenic microflora. In the course of the conducted studies, the effectiveness of the antimicrobial action of dental gels "Bergisept" and "Metrogil-Denta" was proved. At the same time, "Bergisept-gel" has the advantages of specifically inhibiting the growth of P. gingivalis and A. actinomycetemcomitans and practically does not have an antimicrobial effect against Str. salivarius.
DENTAL STATUS FEATURES OF PATIENTS WITH ABFRACTION DEFECTS OF TEETH
Authors: Shashmurina Anna B. , Gladarevskaya Ekaterina I. , Danilenko Svetlana G. , Nikolaev Aleksandr I.
Published: December 2023

The features of the dental status of 128 patients aged 30-49 years with abfraction defects of the teeth were studied. Complaints and anamnestic data, presumably related to the presence of abfraction defects, were recorded. An objective assessment of the severity of hyperesthesia of hard tissues of 193 teeth with abfraction defects in 128 patients was carried out using the Schiff air test. In the examined patients in the area of abfraction defects, a high prevalence of hyperesthesia of teeth necks (92.9%), enamel cracks (69.5%), gum recession without signs of inflammation of the gingival margin (89.1%), the presence of functional overload of teeth with abfraction defects (87.5%). In the study of 75.1% of teeth with abfraction defects, a high degree of hyperesthesia (2-3 points on the Schiff scale) was recorded. Hyperesthesia of the cervical region of the teeth is the leading symptom of abfraction defects, its predictable and guaranteed elimination during direct composite restoration is an urgent task in the complex treatment of these patients.
COMPARATIVE ANALYSIS AND PROSPECTS FOR IMPROVING THE PROPERTIES OF ZINC-PHOSPHATE CEMENTS
Authors: Valynov Anton S. , Chirkova Natalia V. , Kravchuk Elena V. , Morozov Aleksey N. , Derevnina Natalia G.
Published: December 2023

The most common manifestation of a complication in the treatment of patients with fixed denture structures is a violation of fixation. An orthopedic dentist places high demands on fixing cements and most refuse zinc-phosphate cements, preferring materials of a different class. Zinc-phosphate cements are one of the first representatives of fixing materials in the history of dental prosthetics and their formulation, accordingly, is undergoing constant modernization. After the introduction of certain modifications, as a result, the properties are improved. The physicomechanical properties of zinc-phosphate cements used today as fixing materials for fixed structures of dentures in a comparative aspect have been studied. The importance of our research is dictated by the paramount importance of the studied properties. The materials of domestic production were used in the work - "NeoDent" LLC "Celit" Voronezh, "VISCIN" LLC "Raduga-R" Voronezh and a foreign representative of zinc-phosphate cement "Adhedor" SpofaDental, Czech Republic. The research methods included the measurement of compressive strength, the thickness of the cement film and the determination of the net hardening time.
THE EFFECTIVENESS OF THE COMPOSITION IN THE FORM OF GEL FOR ORAL CARE WITH HERBAL COMPONENTS
Authors: Latif Irina I. , Kovalevsky Aleksandr M. , Kraeva Lyudmila A. , Nosova Maria A. , Sharov Aleksey N.
Published: December 2023

The article discusses the results of a clinical and microbiological study of the anti-plaque, anti-inflammatory, hemostatic, antibacterial and anti-adhesive effects of the developed composition in the form of a gel for the care of oral tissues based on aspen bark extract, chlorophyll, dihydroquercitin, D-panthenol, methyl salicylate, the effect of this complex on the pH level of the gingival fluid, the results of a microbiological study to determine the survival of microorganisms such as Streptococcus sanguinis, Streptococcus mitis, Streptococcus oralis, Streptococcus salivarius, Staphylococcus aureus, Enterococcus faecalis, Klebsiella pneumoniae, Pseudomonas aeruginosa, Acinetobacter baumannii, the results of determining the adhesive properties of S. Sanguinis in the presence of a gel composition, the effectiveness of the reduction action indices ONi-S, SBI, PMA, changes in the pH level of gingival fluid, antibacterial and anti-adhesive efficiancy.
AESTHETIC RESTORATION OF TEETH IN A PATIENT WITH ABFRACTION DEFECTS (CASE REPORT)
Authors: Shashmurina Anna B. , Nikolaev Aleksandr I.
Published: December 2023

In detail, at the expert level, a clinical example of aesthetic restoration of teeth with abfraction defects is considered. The medical and technological features of cavity preparation, modified adhesive processing, modeling, grinding and polishing of restorations are described in detail. Long-term results up to 6 years were analyzed. The plan for further supervision of the patient was considered.
EVALUATION OF THE EFFICACY OF VIRTUAL-SIMULATION TEACHING TECHNIQUES IN ENDODONTIC TREATMENT IN THE SYSTEM OF CONTINUING MEDICAL EDUCATION
Authors: Borisova Eleonora G. , Balin Vladimir V.
Published: December 2023

This work represents a completed study on the development and implementation of the developed and optimized virtual-simulation program of continuing medical education (36 hours) to improve the manual skills of therapeutic treatment in dentistry in the module "Direct Restorations" using the evaluation of the survival rate of knowledge and skills obtained.

With the traditional system of practical retraining of military dentists, using the dental clinic as a training base is difficult; the presence of a preceptor is required during the training manipulation; training depends on the clinic schedule and the availability of the pathology being studied; and there is no opportunity to repeat the manipulation or intervention. In addition, evaluation of the level of practical training of trainees is subjective, there is no unified system of its objective assessment [1-4]. Two stages are introduced for the trainees in the continuing medical education system: Stage 1 - assessment of the available practical skills on standard assignments, Stage 2 - assessment of the mastered practical skills. Improving the practical skills of practicing military dentists with the help of simulation training eliminates the risk to the life and health of the patient and trainee, allows you to conduct classes on an individual educational program without taking into account the working hours of the medical organization and the work schedule of the teacher, makes it possible to repeatedly practice the skill and bring the manipulation to automatism, provides objective quality control of its implementation, easily models rare pathologies and clinical cases [1-7].
FORMATION OF THE CAREER TRAJECTORY OF A DENTAL STUDENT USING DIGITAL TECHNOLOGIES AT A MEDICAL UNIVERSITY
Authors: Strahova Natalia V. , Libina Irina I. , Natarova Ekaterina S.
Published: December 2023

This article discusses the use of digital technologies in building the career trajectory of medical university students. The features of the digital model of the development of the career trajectory of a dental student, the requirements of employers and the main problems faced by young professionals at the beginning of their work are shown. Starting from the first year, students are constantly held meetings with employers, Career Days, master classes, trainings, where future specialists have the opportunity to decide on the direction of training.

The dental profession is a dynamically developing specialty, where knowledge in the field of high digital technologies, the latest techniques, work on new equipment is needed.

The conducted survey of students of the Institute of Dentistry of the Burdenko State Medical University showed the need to acquire digital literacy of students during training and the importance of this indicator when applying for a job for employers.
Investigation of the effect of fixing zinc-phosphate cements on the tissues surrounding a fixed denture structure
Authors: Valynov Anton S. , Chirkova Natalia V. , Kryuchkov Mikhail A. , Primacheva Natalia V. , Bobeshko Marina N.
Published: December 2023

Despite the rapid development of orthopedic dentistry and the release of a large number of materials used to fix fixed structures, it is impossible to single out among them an ideal one for every case. There are several classes with significantly different characteristics. Even representatives of the same group have significant differences in properties, which is associated with continuous work on the recipe to adapt to modern requirements.

Every orthopedic dentist tries to choose for himself a material that satisfies all parameters, used in dental practice as a fixing fixed structures. He pays special attention not only to the convenience of working with cements or their physico-chemical, physico-mechanical properties, but also to its bioinertness and biocompatibility.

To assess the effect of fixing materials on surrounding tissues, a comparative assessment was carried out with the measurement of the toxicity index of materials and the papillary-marginal-alveolar index (PMA).
The results of the bacteriological method of studying patients with removable lamellar dentures, by improving the prevention and treatment of oral dysbiosis
Authors: Chirkova Natalia V. , Shalimova Natalia A. , Andreeva Elena A. , Polushkina Natalia A. , Vecherkina Zhanne V. , Pshenichnikova Diana I.
Published: December 2023

The oral cavity is essentially an ecological system. This system is part of both the organism itself and the external environment. The normal microflora of the oral cavity guarantees resistance to colonization. This can be designated as the main goal for any factor that directly or indirectly affects adhesion. It also affects the normal resistance of the oral cavity to external manifestations. The human body is constantly functioning and in close contact with the surrounding world and its organisms. Thus, the human body itself is densely populated with various types of microorganisms. These microorganisms are divided by origin, composition, type, size, type of vital activity. In order to study the biotype of the human body as thoroughly and in detail as possible, an approach based on the ecological principle has been formed in this study.

To identify the patterns of the existence of microorganisms, we apply an ecological approach that allows us to reliably describe the structure of bacterial communities that make up the biocenosis. Removable plate prosthesis will necessarily affect the human body in some way, and this measure of influence can be both positive and negative. A positive effect is observed in the exact and complete replacement of defects in the dentition. The negative effect can be characterized by both inflammatory reactions and mechanical damage. Also, the materials used for the manufacture of removable plate prostheses may be incorrectly selected. Depending on the already existing diseases of a person, his physiological characteristics, habits, it is necessary to treat the choice of consumables as appropriately as possible.

It is impossible to overestimate the positive effect of the microflora of the human body in the processes of metabolism, digestion, etc. Thus, the issue of preservation of human microflora and prevention of dysbiosis is relevant in modern science.
INTERRELATION RECURRENCE RATE OF CHEILITIS FROM THE LEVELS OF VITAMIN D
Authors: Borisova Eleanora G. , Isaeva Ludmila I. , Khrustaleva Julia A.
Published: December 2023

Vitamin D deficiency is a widespread problem among carriers, people living in acute lack of sunlight in northern latitude regions, this is the result of low serum concentrations of the vitamin. Chronic lip fissure and meteorological cheilitis are the most common forms of cheilitis among residents of the Far North. The role of vitamin D deficiency has not been studied in patients with these diagnoses. The purpose of the study is to measure the level of vitamin D in the blood serum in patients with chronic lip fissure and meteorological cheilitis, as well as to dynamically study the dependence cases of disease recurrence on the concentration vitamin D. The study was conducted in 79 residents of the Murmansk region for 12 months. Diagnostic results have established that low serum vitamin D concentrations support the recurrence of meteorological cheilitis and chronic cleft lip. The use of vitamin D to maintain a normal level of vitamin in the blood serum improves the regenerative ability of the lip skin, maintains the barrier function of the epithelium, and reduces cheilitis recurrence rate. The study found that in the conditions of the Far North one of the mandatory components of the prevention and pathogenetic therapy of meteorological cheilitis and chronic lip fissure should be vitamin therapy with cholecalciferol preparations.
Results of a study of zinc-phosphate cements for fixation of fixed orthopedic structures under the influence of material hardening time
Authors: Chirkova Natalia V. , Valynov Anton S. , Polushkina Natalia A. , Vecherkina Zhanne V. , Bobeshko Marina N.
Published: December 2023

Patients often prefer non-removable prosthesis designs to replace dental row defects, given their undeniable benefits. However, there is a possibility of developing complications during prosthetics, it is impossible to completely exclude medical errors and errors of the dental technician.

Dentists know that in 20% of cases, prosthetics with non-removable types of prostheses end unsuccessfully due to errors in treatment, as well as improper use of fixing cements at the stage of storing the prosthesis. About 20% of cases are complications in the near future after prosthetics during the operation of the prosthesis. The proportion of complications due to carious tooth damage under prostheses can reach more than 49%.

Non-removable prostheses, firmly fixed by zinc-phosphate cements, gain a number of advantages by choosing this particular material: a slight percentage of shrinkage; low percent solubility; increased strength; creation of a holding layer between tissues of the oral cavity and a selected type of prosthesis.

Our study is devoted to the issues of assessing the most significant qualities of fixing cements, which is of great practical importance.
Laboratory assessment of the accuracy of the fit of artificial crowns to tooth stumps
Authors: Khudaleeva Kristina A. , Abolmasov Nikolay N. , Massarsky Ivan G.
Published: December 2023

Relevance. Among the variety of reasons for unsatisfactory results of treatment of patients with artificial crowns and their premature removal or cementation, the researchers highlight the development of secondary caries. One of the significant reasons for its occurrence is the quality of the marginal fit of artificial crowns.

The goal is to perform a laboratory assessment of the thickness of the cement film in the area of ​ ​ the edge of the artificial crown and establish the degree of its influence on the probability of the development of the carious process.

Procedure. Splints of 50 freshly removed teeth covered with artificial crowns were made, on which the thickness of the cement film was measured, and the presence of caries at the edge of the artificial crown was determined.

Results. The development of caries under the artificial crown is typical of teeth dissected with a ledge. The threshold value of the thickness of the cement film, above which caries more often developed in the studied sample of teeth, was 115-120 microns. The probability of unacceptable thickness of the cement film and the development of caries in teeth prepared with a shoulder is 6.6 times higher than in preparation without a shoulder.
Clinical substantiation of the platelet-rich plasma effectiveness in complex surgical treatment of gingival recession
Authors: Moiseeva Natalia S. , Kharitonov Dmitry Yu.
Published: December 2023

Gingival recession is a non-inflammatory pathological process characterized by apical migration of the marginal gingiva below the CEJ. The use of platelet-rich plasma is one of the current technologies in the complex treatment of gingival recession. The aim of the study was to increase the effectiveness of surgical treatment of gingival recession using platelet plasma. As a result of the treatment of gingival recession I, II and III Millers classes, the coverage area of the recipient surface was 84%, 77% and 60%, accordingly; the thickness of the keratinized gingiva increased by an average of 2 times. The use of platelet plasma in the complex treatment of gingival recession optimizes the healing period in the regeneration phase, improves the microcirculation of periodontal tissues and reduces the duration of treatment by an average of three days; shows more efficiency due to less physiological shrinkage of the graft over time.
SPECTROPHOTO AND DIGITAL COLORIMETRIC DETERMINATION INDICATOR OF BETA-ADRENOREACTIVITY OF ERYTHROCYTE MEMBRANES OF PATIENTS WITH BRONCHIAL ASTHMA
Authors: Rudakova Lyudmila V. , Batishcheva Galina A. , Nikitina Tatiana N. , Vetrova Elena N.
Published: December 2023

The change in the adrenoreactive properties of membrane and cellular structures under the influence of catecholamines makes it possible to consider the beta-adrenergic reactivity of the erythrocyte membrane (-ARM) as a systemic indicator of the organism's adrenoreactivity. To assess adrenoreactivity, a technique is used based on a quantitative assessment of the degree of inhibition of hypoosmotic hemolysis of erythrocytes in vitro in the presence of the beta-blocker propranolol. The article presents data on the comparison of spectrophoto- and colorimetric determination of erythrocyte membrane beta-adrenoreactivity based on the registration of erythrocyte hemolysis with digital signal processing. A smartphone was used to register the images of the analyzed samples. Photography was carried out in a special box under standard lighting conditions. The chromaticity of the obtained images was evaluated using the Photoshop program within the RGB color model intended for computer color rendering. The obtained RGB values were used for quantitative determinations. The study was performed on 20 blood samples of patients suffering from bronchial asthma. The discrepancy between the results of determining -ARM using the colorimetric and spetrophotometric methods was no more than 5.6%, which indicates the possibility of replacing the spectrophotometer with image registration in digital format using software.
The method of medical anisotropy in the diagnosis of the pathological process of scarring of soft tissues after inflammatory diseases of the maxillofacial region
Authors: Khelminskaya Natalia M. , Fedorova Valentina N. , Tcherepanova Ekaterina V. , Posadskaya Alexandra V. , Faustova Ekaterina E. , Kravets Viktor I. , Prityko Andrey G. , Voronin Pavel A. , Techiev Soslan K. , Vinikurova Lyudmila M.
Published: December 2023

The presented article is devoted to the diagnostic method of anisotropy in assessing the formation of the type of pathological scar in patients after surgical treatment of acute inflammatory diseases.

Pathological scar deformities in a significant area cause changes in aesthetics, lead to anxiety and depressive states, and sometimes cause severe functional disorders
INVESTIGATION OF PROBIOTICS-SORPTION PROPERTIES OF THE COMPOSITION BASED ON POMACE
Authors: Ryabinina Elena I. , Zotova Elena E. , Nikitina Tatiana N. , Ryabinin Stanislav V.
Published: December 2023

The use of enterosorbents to relieve intoxication and to increase the content of prebiotics in the body is a topical problem of every second metropolis resident. The pharmaceutical market offers a huge number of enterosorbents, some of which can cause negative consequences (for example, mechanical damage, constipation etc.). The others that are more compatible with the body, for example, pectins, are expensive due to the energy-intensive process of their isolation. We offer a preparation based on pomace powder (60%) with the addition of starch, kaolin and pectin from sea grass eelgrass (Zostera marina) (6%). The powder is obtained by a previously developed and patented method and has an established sufficiently high sorption activity. At the same time, apple pomace also contains pectin, which is a substrate for the growth of beneficial microorganisms living in the colon.

The article presents the data of a comparative analysis of the sorption activity of the developed powder and a number of enterosorbents offered by the pharmaceutical market in relation to standard test substances: methylene blue and pharmaceutical gelatin. It is shown that the composite enterosorbent obtains effective sorption properties and equals to common sorbents. When dissolved in water, the powder acquires a gel-like consistency that gives it additional therapeutic and preventive properties. The use of apple pomace as a basis enables to reduce the cost of producing expensive pectin and make it more affordable for the population.
Advanced glycation end products and breast cancer: a review of the literature
Authors: Alipour Sadaf , Eskandari Amirhossein
Published: December 2023

Advanced glycation end products (AGEs) are mediators of chronic inflammation, which is recognized as an underlying process in carcinogenesis. The role of AGEs in cancers is the focus of recent studies. Breast cancer (BC) is the most common cancer in the world and the etiology is unknown, but some risk factors have been defined; including obesity and diabetes. Both of these disorders are linked to AGEs; thus, BC and AGEs might be associated. AGEs in the human body either derive from the glycation of proteins and lipids in the blood, or from the dietary AGEs (dAGE). AGEs are mainly associated with disease states or aging, including diabetes mellitus, cardiovascular and cerebrovascular disorders, Alzheimer, renal failure, arthritis, skin problems, viral infections, and osteoporosis. Some bioeffects of AGEs are consistent with the chain of events that occur during carcinogenesis. However, the studies about the role of AGEs in specific cancers are not conclusive, and some recent literature, especially clinical studies do not support the theory of the association between AGEs and cancers,. There does not exist a great deal of studies about the role of AGEs in BC, but the subject has been addressed recently. The present evidence is rather in favor of the association of AGEs and breast cancer; however, the direction and type of this association are unclear. In-vitro studies show that AGEs promote features of invasiveness in BC, but clinical studies show diverse findings. In this study, we present an overview of the core existing knowledge about AGEs and their relation with diseases; then provide a brief review of the results of studies that have investigated the association of AGEs and cancer, and then proceed to a concise discussion about studies on AGEs and BC.
Survival of GEJ and gastric adenocarcinoma patients admitted at Imam Khomeini and Aram oncology clinic and treated with preoperative EOX chemotherapy
Authors: Farahat Ali , Emami Amirhossein , Nodehi Seyed Reza Safaei , Roudini Kamran , Shahi Farhad
Published: December 2023

Objective: We aimed to investigate safety and efficacy of preoperative chemotherapy using EOX regime in patients with locally advanced gastric and GEJ cancer who were admitted at Imam-Khomeini Oncology clinic and Aram clinic.
Method: We performed a mix-cohort study in 51 gastric cancer patients. In the beginning, we performed contrast thorax and abdominal CT scan or ECO cardiograph to determine cancer staging. After that, each patient received 3-weeks EOX regime in 6 cycle. After each three cycles follow-up CT scan was performed to assess any possible progression. Response to the treatment, Overall survival, and Progression-Free Survival were the main outcomes that we evaluated in the current study. We used Kaplan-Meier approach and Cox regression to address survival rate and its prognostic factors
Results: Overall, 72.5% percent were male and mean age of study participants was 57.6. Complete response rate was observed in 11.1%, while 51.1% showed partial response. Median of overall survival and Progression-Free Survival was estimated 35.0 and 28.0 month, respectively. The 5-year overall survival was 74.2% and for PFS it was estimated at 57.7%.
Conclusion: Preoperative chemotherapy using EOX regime could increase survival rate among patients with gastric and GEJ cancer.
BRAF-V600E Protein Expression in Canine Malignant Cutaneous Melanoma, in Accordance with the Introduction of Biomarkers in Comparative Oncology Studies
Authors: Mehrani Hossein , Yasini Seyedeh Parastoo , Muhammadnejad Ahad , Shirazi Beheshtiha Seyed Hamed
Published: December 2023

Background: Melanoma is the cause of death for 1.3% of all cancer patients in humans. The key role of the BRAF protein in the progression of human melanoma has been confirmed, and its prognostic significance has been revealed. Because canine cancer resembles human cancer in biological behavior and molecular abnormalities, BRAF protein may be expressed in canine melanoma, the same as human melanoma. Despite the investigation of the BRAF mutation in canine melanoma, the status of BRAF at the protein level in canine skin melanoma has not yet been examined.
Methods: Thirty-two formalin-fixed, paraffin-embedded tissue samples of canine malignant cutaneous melanoma were randomly selected. After cutting into 3-μmthick sections, the samples were evaluated for BRAF protein expression by immunohistochemistry and using the anti-BRAF V600E (VE1) mouse monoclonal antibody
Results: The BRAF status was assessed using the Allred scoring system. Among the 32 samples examined, 21 samples were negative, and 11 cases showed high BRAF protein expression.
Conclusion: The detection of positive BRAF expression in 34.3% of canine cutaneous melanoma samples could be a step forward to improving treatment options, using dogs as an animal model in human melanoma clinical trials, and possibly identifying a new prognostic biomarker in canine melanoma.
Smoking and alcohol, both alone and in combination, for risk of gastric cancer: A systematic review
Authors: Hosseinie Fatemeh , Farhanji Mahdieh , Meshkinyazd Ali , Khakzad Mohammad Reza
Published: December 2023

Introduction: Stomach cancer is the fifth most common cancer and the fourth leading cause of cancer deaths worldwide in 2020. Moderately increased risk of stomach cancer has been associated with tobacco smoking and Alcohol drinking. In this systematic review, we summarized the current knowledge on the relation between smoking and alcohol, both alone and in combination, to the risk of gastric cancer.
Method: This study was conducted in 2023 with a structured overview in the Science Directe , PubMed, Web of Science (ISI) databases. We investigated the studies that were published between 2010 and 2023. In the first step, articles were extracted based on their titles and abstracts; the quality of 58 articles was evaluated using the STORBE tool. Inclusion criteria were English language (first step), year of the study and the study type (second step).
Findings: Of these 39 articles, 17 ones were case-control studies, 21 were cohort studies, one was a descriptive study. eleven articles were related to alcohol consumption and risk of gastric cancer, twenty-three articles were related to smoking and risk of gastric cancer, five articles were related smoking and alcohol consumption in combination and risk of gastric cancer. Many studies reported a significant association between alcohol and gastric cancer risk. Also, three studies showed that smoking acts as a risk factor for developing gastric cancer only in certain genotype and not in all people.
Conclusion: Based on the best our knowledge and present studies, consumption of alcohol and smoking are risk factors of gastric cancer. It is better to conduct more studies on this issue in different populations in the future. We also suggest that future studies focus more on the intracellular mechanisms of these associations than on epidemiological outcomes.
Perception of cancer patients and their attendants during pandemic of COVID-19: an experience from tertiary care center, Pakistan
Authors: Rasheed Afshan Asghar
Published: December 2023

Introduction: Cancer patients have concerns about treatment during COVID 19 pandemic virus as well as its impact on their health. This survey was conducted to ascertain perception of cancer patients and their attendants during this pandemic.
Method & Result: This cross sectional study was conducted at Oncology OPD of SIUT, from May 2020 to July 2020 on cancer patients along with their attendants. Among 306 patients, 68.9 % received chemotherapy. In response of each question, 1st one belonged to patients and 2nd was related to attendants. Only positive answers are reported here. For increasing gap of chemotherapy during the pandemic COVID 19, 58.3% vs 38.4% agreed with doctor recommendation. For start of single agent chemotherapy instead of combination regimen, 41% vs 19% agreed. For hospitalization 41.5%, vs 47.7% depicted inclination towards admission whereas for mental health questions, 63.7% vs 51.3% were neither afraid nor had psychological issues 79.7% vs 25.8% respectively. About COVID -19 testing, 66% vs 22.5%wanted to be tested. If results turned out positive, 82.2% vs 24.7% would go in isolation.
Conclusion: This study provides evidence of perception of cancer patients with their attendants from resource restrained country. Our study confirms that for disease like cancer, fear of the illness is always more paramount then any infection.
How to report pathological indicators of gastric malignancies in a hospital in Iran, a developing country
Authors: Moghimi Mansour , Jafari Mehran , Ansari Kazem
Published: December 2023

Objective: The aim this study was How to report pathological indicators of gastric malignancies in a hospital in Iran, a developing country.
Method: This cross-sectional study was conducted on 174 patients. Study variables including age and sex, type of biopsy, extent of gastric tissue involvement, exact anatomical location, tumor size, histological grading, invasion of surrounding tissues and lymph node metastasis were extracted from patients’ records. Data were analyzed using SPSS 22 software. Frequency and percentage were reported using descriptive statistics. Graphs were drawn using Excel 2010.
Results: 174 patients were studied in this study; that 63.8% of the patients were female (n= 111). The prevalent of reports were related to the histology of adenocarcinoma (n = 136, p = 78.20), tumor size (n = 89, p = 51.15), anatomical exact location (n = 90, p = 51.70), respectively. Among the 90 patients for whom the exact anatomical location was reported, the most reports were related to the antrum (n = 38, p = 42.23). The highest prevalence of histological type of adenocarcinoma was related to Poorly differentiated (n = 57, p = 41.94).
Conclusion: The findings of this study showed that the way of reporting pathological indicators in gastric malignancies in the studied cases was somewhat appropriate.
Effects of Psychotherapy Interventions and Mental Activity in Control of Pain in Patients with Breast Cancer
Authors: Farahani Sepideh , Fakhim Sanaz , Amiri Shahin , Mousavi Fatemeh , Azad Mehdi
Published: December 2023

Background and aim: Pain is known as the greatest complication of cancer and cancer-related therapies. Therefore, control of pain has been considered with pharmaceutical and non-pharmaceutical methods. This study was performed to survey of mental and psychological activities in control of pain in patients with breast cancer.
Methods and materials: 166 patients with breast cancer were selected randomly in a specialist hospital in Tehran, Iran and the questionnaire, and the consent letter was completed by them. Patients were categorized into three groups; first group includes patients with great spirits and hope for complete recovery. Second group includes patients with major depression, and third group includes patients with moderate spirits. Most data in this study were for the primary group.
Results: According to data, in the deviation group, no acceptable mean of pain was obtained. In the hypothesis group, mean of pain was more passable. In the group which patients were conversed with own, mean of pain was more than previous two groups. The lowest mean of pain was related to the negative hypothesis group, and the highest mean of pain was related to patients who were prayed and hoped.
Conclusion: The obtained results showed that deviation and activity of mental are good way to control and reduce of pain. This method is without side effects, inexpensive and accessible, which reduces of pain in patients. This study suggests that use of mental activity is a non-pharmacological treatment to reduce of pain in outpatient and hospitalized patients.
Composite Resin Bond Strength to Zirconia and Base Metal Alloys Using Two Types of Intraoral Porcelain Repair Systems
Authors: Arshad Mahnaz , Gordan Rasamedin , Farrokhi Paniz , Habibzadeh Sareh
Published: December 2023

Objectives: This study aimed to evaluate the shear bond strength (SBS) of two repair composites (Crea.lign vs. PermaFlo) to a base metal alloy and zirconia ceramic.
Materials and Methods: Sixty-four discs (12mm diameter, 1mm thickness) were fabricated using Wirobond base metal alloy and zirconia. They were then bonded with their respective composite resins (N=16) in each of the two porcelain chipping repair kit subgroups consisting of PermaFlo and Crea.lign. All specimens were stored in 37°C distilled water for 24 hours. Half of them were subjected to 10,000 thermal cycles (5-55°C, 30s). All specimens were tested for SBS with a universal testing machine. Failure types were analyzed using a digital camera. Analysis of the data was done by two-way ANOVA and Bonferroni post-hoc tests.
Results: SBS was significantly affected by the type of composite resin. PermaFlo had a significantly higher SBS than Crea.lign to base metal alloy (P<0.001) and zirconia ceramic (P<0.001). Thermocycling decreased the SBS of both composites to base metal alloy (P<0.001) and zirconia (P<0.001).
Conclusion: A universal adhesive could provide higher shear bond strength of zirconia and base metal alloy to composite resin than Crea.lign composite and the MKZ primer supplied by its manufacturer.
Mindfulness-Based Interventions for Postpartum Depression: A Systematic Review and Meta-Analysis
Authors: Yang Miaoxiong , Song Baozhi , Jiang Yatao , Lin Ying , Liu Jiahua
Published: December 2023

Background: We aimed to investigate the intervention effect of mindfulness-based interventions (MBIs) in patients with postpartum depression.
Methods: The method of computer and manual keyword retrieval was used to search PubMed, Web of Science, Cochrane Library. Literature included in the study was assessed for quality and meta-analysis was performed using RevMan 5.3 software.
Results: Twelve articles were finally included in the study and the meta-analysis showed that 6 articles used the Edinburgh Postnatal Depression Scale (EPDS) to compare MBIs with conventional therapy, and the statistical heterogeneity between the combined results was low (P=0.18, I2=32%). The level of depression in postpartum depression patients was lower in the MBIs group than in the conventional group [MD=3.13, 95%CI (2.57, 3.70), P<0.00001]. Based on the Beck Depression Inventory (BDI), the comparison between MBIs and conventional therapy had low statistical heterogeneity between the combined results (P=0.56, I2=0%). The level of depression in patients with postpartum depression who received MBIs was significantly lower than in the conventional care group [MD=5.89, 95%CI (4.88, 6.91), P<0.00001]. Subgroup analysis showed that the best intervention duration for MBIs for postpartum depression was within 4 weeks (SMD=-1.785), each session≦60 minutes (SMD=-1.435), and participants had to complete the best three times per week (SMD=-2.185).
Conclusion: MBIs can alleviate depression in women, thereby facilitating their adjustment to new life. It is recommended to practice mindfulness meditation for 30 minutes per day.
Prevalence and Antibiotic Resistance of Clostridioides (Clostridium difficile) In Meat and Meat Products: A Systematic Review and Meta-Analysis
Authors: Esfandiari Zahra , Shoaei Parisa , Vakili Bahareh , Farajzadegan Ziba , Tarrahi Mohammad Javad , Emami Zahra , Fakhri Yadolah , Weese J. Scott , Mahmudiono Trias
Published: December 2023

Background: Meat and meat products are introduced as one of the frequent sources of Clostridioides difficile. We aimed to determine the prevalence and antibiotic resistance of C. difficile isolates in meat and meat products using a systematic review and meta-analysis.
Methods: A literature search was performed in the primary international and bibliographic databases such as MEDLINE (PubMed), Cochrane Library, Embase, Scopus, and Web of Science to achieve all articles related to the prevalence and antibiotic resistance rates from 2007 to 2022.
Results: The 278 retrieved articles were reduced to 54 worldwide eligible studies after screening and matching inclusion/ exclusion criteria. C. difficile was examined in different types of samples and its resistance to 10 antibiotics. The pooled prevalence of C. difficile was 3.4% in all samples. C. difficile pooled prevalence was detected in fish, poultry, and red meat groups with 6.9%, 5.2%, and 3.2%, respectively. Regarding antibiotic resistance, the highest pooled prevalence was for ciprofloxacin (86.6%), followed by clindamycin (42.6%) and erythromycin (34%). The lowest pooled prevalence was observed in metronidazole (7.6%), vancomycin (6.6%), and chloramphenicol (6%).
Conclusion: Low resistance was found to commonly used drugs for C. difficile infection (CDI) treatment. Since each antibiotic can be predisposing cause for CDI development, this finding possibly will be  warning from a One Health viewpoint about the misuse of antibiotics in the chain of farm to fork including agriculture, animal husbandry and the food industry and also their injudicious use in medicine.
The Effects of Heat Stress on Bakery Workers: A Systematic Review
Authors: Khazaei Parvaneh , Sahlabadi Ali Salehi , Ramezanifar Soleiman , Mehrifar Younes , Khadiv Elahe , Rastegari Pedram , Gharari Noradin
Published: December 2023

Background: Working in hot environments can cause diseases and reduce performance by upsetting the balance of physiological parameters of workers' bodies. Bakers are among the people exposed to heat stress continuously and daily. This review study aimed to investigate the effect of heat stress on bakers.
Methods: In this review study, the related articles based on keywords were reviewed using “IranMedex”, “Science Direct”, “PubMed”, “Scopus”, “Web of Science”, “SID”, “Google Scholar”, and “Magiran” databases from the years 2000 to 2021. The used search terms were "Heat stress", "Heat strain", "Heat exposure", "Heat waves", "Workplace", "Baker", and "health effects". In order to extract the required data, all parts of the articles have been reviewed.
Results: Out of the 16 studies reviewed in this study, 43.75% were cross-sectional, 25% were descriptive cross-sectional, and 31.25% were performed according to other study designs. In all of the studies, the WBGT index was used to assess ambient heat stress. In most studies, the mean exposure temperature was higher than the WBGT-ACGIH limit, especially among traditional bakery workers. The findings showed that exposure to thermal stress significantly affects some hematological parameters of blood, oxidative stress, heart rate, and body temperature.
Conclusion: The situation of heat stress in the bakery environment is worrying in terms of health and reduced productivity of employees. Therefore, it is essential to take the necessary preventive and control measures to reduce heat stress and the resulting strain.
Evaluation of MicroRNA as Minimal Residual Disease in Leukemia: Diagnostic and Prognostic Approach: A Review
Authors: Amiri Bahareh Shateri , Sabernia Neda , Abouali Behdokht , Amini Parya , Rezaeeyan Hadi
Published: December 2023

Various factors are effective in the development of minimal residual disease (MRD), one of which is MicroRNAsmiRNAs miRNAs and their dysfunction in gene expression have influential role in the pathogenesis of leukemia. Nowadays, treatments that lead to the suppression or replacement of miRNAs have been developed. Focusing on the role of miRNAs in managing the treatment of leukemia, in this review article we have investigated the miRNAs and signaling pathways involved in the process of apoptosis and cell proliferation, as well as miRNAs with oncogenic function in malignant leukemia cells. Among the studied miRNAs, miR-99a, and miR-181a play an essential role in apoptosis, proliferation and oncogenesis via AKT, MAPK, RAS, and mTOR signaling pathways. miR-223 and miR-125a affect apoptosis and oncogenesis via Wnt/B-catenin, PTEN/PI3K, and STAT5/AKT/ERK/Src signaling pathways. miR-100 also affects both apoptosis and oncogenesis; it acts via IGF1 and mTOR signaling pathways.
The Relationship between Smartphone Use Motives, Social Capital, Digital Literacy, and Life Satisfaction in Elderly Koreans
Authors: Lee Ji-Hyeon , Bae Sung Man Bae
Published: December 2023

Background: As the elderly population increases, interest in life satisfaction in old age is increasing. We aimed to verify the relationship between social capital, smartphone use motives, and digital literacy and life satisfaction in Koreans aged 50-69 yr.
Methods: The data of 7,521 late-middle-aged and older adults from the 2019 survey on smartphone overdependence conducted by the National Information Society Agency were analyzed by hierarchical multi-regression analysis.
Results: A hierarchical multiple regression analysis indicated that income(β=0.062) and educational background(β=0.054) were positively related to life satisfaction. Among the smartphone use motives, lifestyle motive(β=-0.069) was negatively related to life satisfaction. Digital literacy(β=0.145) and Social capital(β=0.425) were positively related to life satisfaction.
Conclusion: Digital literacy and social capital were positively associated with life satisfaction. In addition, this study considered the effects of lifestyle-based apps, while past studies only focused on communication- and leisure-based smartphone activities as factors influencing life satisfaction in adults in their 50s-60s. This study can provide a theoretical framework for therapeutic interventions to improve life satisfaction in the elderly.