bluuebunny/crossref_metadata_2025 huggingface dataset:
The Devil in its Details: Unravelling the Epitopes in COVID-19 Surface Glycoprotein with the potential for Vaccination and Antibody Synthesis
Authors: Baig Abdul Mannan
Published: March 2020

With over 75762 patients infected and 2130 deaths been reported, the mortality and morbidity caused by the recent outbreak COVID-19 infections are proving colossal when compared to similar epidemics caused by SARS and MERS variant of coronavirus in the past. It was aimed to identify a receptor-binding domain (RBD) in surface glycoprotein (sGP) of COVID-19 and predict epitopes that are capable of interacting with major histocompatibility complex (MHC) alleles to evoke antibody production in vivo. Bioinformatic computational tools were used to analyze the well-studied sGP and the RBD in SARS-CoV and compare it with their homologs in COVID-19. In silico methods that predict epitopes capable of binding MHC allele were used to identify sequences in RDB of sGP in COVID-19 with the intention of discovering sequences that can be used for vaccination and production of monoclonal antibody (mAbs) against COVID-19. The results indicate that COVID-19 has a conserved RBD in the sGP with differences in its sequences that can be exploited for vaccination and manufacturing of specific antibodies against this variant of coronavirus. Reported are 10 sequences of epitopes that are predicted to bind the MHC class I and class II alleles and that do not cross-react with human proteins. Testing in vitro and in animal models can accelerate the translational utility of vaccinating and efficacy of mAbs against the COVID-19 virus.
Clinical and radiological features of patients with 2019 novel coronavirus (SARS-CoV-2) in Haikou, China
Authors: Chen Hui Juan , Qiu Jie , Wu Biao , Wang Zhen Ping , Chen Yang , Chen Feng
Published: March 2020

To describe the clinical and radiological findings of patients confirmed with 2019 novel coronavirus disease (COVID-19) infection in Haikou, China. A total of 67 patients confirmed with COVID-19 infection were included in this study. 50 were imported cases. Most infected patients presented with fever and cough. The typical CT findings of lung lesions were bilateral, multifocal lung lesions (52[78%]), with subpleural distribution, and more than two lobes involved (51[78%]). 54 (81%) patients of COVID-19 pneumonia had ground glass opacities. Consolidation was in 30 (45%) patients, crazy paving pattern or interlobular thickening in 17 (25%), adjacent pleura thickening in 23 (34%) patients. Additionally, baseline chest CT did not reveal positive CT findings in 7 patients (23%), but 3 patients presented unilateral ground glass opacities at follow-up. Importantly, the follow-up CT findings were fitted well with the clinical outcomes.
Using Artificial Intelligence Techniques for Prediction and Estimation of Photovoltaic System Output Power
Authors: Nurwaha Deogratias
Published: March 2020

Two artificial intelligence methods, namely, support vector machines (SVM) and gene expression programming (GEP), were explored for prediction and estimation of the Photovoltaic (PV)output power. Measured values of temperature T (°C) and irradiance E (kWh/㎡) were used as inputs (independent variables) and PV output power P (Kw) was used as output (dependent variable). The statistical metrics were used to assess the predictive performances of the methods. The results of the two models were estimated and compared. The results showed that the two techniques performances are better and similar. Using GEP technique, the relationships between the two parameters and output power were established. Importance of each parameter as contributor to PV output power was also investigated. The results indicated that the SVM and GEP would become the powerful tools that could help estimate the PV output power capacity reserve.
Continued discussion on conventional versus Islamic banks: combining financial ratios and efficiency
Authors: Imdadul Haque Mohammad , Rumzi Tausif Mohammad , Ali Anis
Published: March 2020

Two different types of banking systems, Islamic and conventional, dominate the banking structure in Saudi Arabia. The purpose of this paper is to contribute to the ongoing debate as to which of the two is better. Using data for the period 2014–2018, the study compares Islamic and conventional banks. It combines traditional financial ratios, Return on Assets (ROA) and Return on Equity (ROE), with Data Envelopment Analysis (DEA) to perform a comprehensive analysis. In terms of ROA, the performance of conventional banks is better than that of Islamic banks, but in terms of ROE, vice versa. DEA results show that conventional banks are more efficient than Islamic banks. In fact, in terms of ROA and ROE, Al Rajhi Bank, an Islamic bank, is the best performer. But in terms of efficiency scores from DEA, Al Rajhi ranks seventh among all banks, while NCB, a conventional bank, ranks first. Issuing shares and utilizing funds in profitable options, such as loans and advances to increase net income, are the policy recommendations for Islamic banks to further improve. In addition, as the study finds no correlation between the ratio and efficiency scores, it proposes to use a combined measure of ratio analysis and efficiency analysis for a comprehensive assessment of bank performance.
No-arbitrage one-factor term structure models in zero- or negative-lower-bound environments
Authors: Tarelli Andrea
Published: March 2020

One-factor no-arbitrage term structure models where the instantaneous interest rate follows either the process proposed by Vasicek (1977) or by Cox, Ingersoll, and Ross (1985), commonly known as CIR, are parsimonious and analytically tractable. Models based on the original CIR process have the important characteristic of allowing for a time-varying conditional interest rate volatility but are undefined in negative interest rate environments. A Shifted-CIR no-arbitrage term structure model, where the instantaneous interest rate is given by the sum of a constant lower bound and a non-negative CIR-like process, allows for negative yields and benefits from similar tractability of the original CIR model. Based on the U.S. and German yield curve data, the Vasicek and Shifted-CIR specifications, both considering constant and time-varying risk premia, are compared in terms of information criteria and forecasting ability. Information criteria prefer the Shifted-CIR specification to models based on the Vasicek process. It also provides similar or better in-sample and out-of-sample forecasting ability of future yield curve movements. Introducing a time variation of the interest rate risk premium in no-arbitrage one-factor term structure models is instead not recommended, as it provides worse information criteria and forecasting performance.
Serum anti-Müllerian hormone levels during estrus and diestrus in mares
Authors: DAL GAMZE EVKURAN , KASIKCI GUVEN
Published: March 2020

Anti-Müllerian hormone (AMH) is a homodimeric glycoprotin secreted by granulosa cells in postnatal females. AMH plays an important role in follicle recruitment. The aim of the study was to analyse AMH concentrations under the guidance of circulating estradiol and progesterone levels in mares. The study was conducted on 25 non-lactating mares with regular estrous cycles. Blood samples were collected during estrus and diestrus to analyse estradiol, progesterone and AMH concentrations. Estradiol and progesterone concentrations were significantly different (P < 0.001) between estrus and diestrus. AMH concentrations in estrus were significantly higher than those in diestrus (P < 0.05). According to the authors’ knowledge, this is the first report to suggest that the sexual cycle stage affects AMH concentrations in mares. Further investigations are needed to reveal factors affecting the AMH production and secretion pattern throughout the sexual cycle.
Early clinical predictors of diarrhea in the first fifteen days in dairy calves and their relationship with passive transfer status
Authors: TOPAL ONUR , BATMAZ HASAN
Published: March 2020

The neonatal period is very important in calves. It is extremely important to closely monitor newborn calves with good colostrum management during this period. In this study, the aim was to investigate whether the clinical parameters in the first 15 days after calves are born are correlated with diarrhea and whether those values are the early clinical predictors of the diarrhea that will occur in this period and also to investigate the correlation between diarrhea and the failure of transfer of passive immunity (FTPI). Eighty-two Holstein calves were used in the study. The calves were examined systemically every day and were scored according to a standard form. In the first 15 day period, 64.63% of the calves had diarrhea. In diarrheic calves, the most common findings on the previous day without diarrhea were fetid feces (43.40%), changes in the consistency and color of feces, and a decrease in the temperature of the ears (35.85%). According to non diarrheic calves, fetid feces (P < 0.01), changes in the consistency and color of feces, and nasal discharge were more common among diarrheic calves on the day before diarrhea (p < 0.001). The duration of diarrhea in calves with FTPI was longer than without FTPI. As a result, it is important for calves to be monitored daily in the first 15 days, looking for early signs of diarrhea in this period, namely fetid feces and changes in the consistency and the color of the feces. In addition, coexistence of any fecal changes with the decrease in the temperature of the ears may be clinical predictors of diarrhea. As a result of the daily monitoring of the calves, although the morbidity rate was high, none of the animals died.
RIO E PERTENCIMENTO EM PROCESSOS DE URBANIZAÇÃO: O CASO DE CACHOEIRO DE ITAPEMIRIM/ES
Authors: Bernardo Jéssica Lacerda , Espindula Lidiane
Published: March 2020

O presente artigo tem como objetivo analisar e compreender a evolução do vínculo entre homem, rio e cidade, levando em consideração a relevância histórica, paisagística, econômica e cultural dessa relação no decorrer dos séculos, até a ruptura nos tempos atuais, com a finalidade de compreender se é possível que cidades como Cachoeiro de Itapemirim/ES continuem se desenvolvendo ignorando essa ligação. Com base qualitativa a pesquisa é fundamentada em consulta bibliográfica e de pesquisas realizadas in loco, estudos de caso, análise de fotografias aéreas, juntamente a levantamentos fotográficos. Contatou-se que é de fato possível e necessário reestabelecer a relação de proximidade entre rio e cidade e que a relação de pertencimento se dá de forma em que as cidades pertençam aos rios e não o contrário como é exposto.
La ciudad neoliberal: conceptos y realidades de Dubái
Authors: De la Torre Vázquez Marina Inés
Published: March 2020

El llamado “neoliberalismo” tiene su antecedente en la doctrina del liberalismo clásico, cuyos postulados económicos de origen han sido orientados hacia una visión idealizada de la supremacía del mercado, basada en la competencia despersonalizada y la insolidaridad. Esta suerte de liberalismo desideologizado impone la lógica competitiva del mercado como única alternativa para el desarrollo humano, reproduciendo asimetrías y polarizaciones en la configuración de los territorios urbanos. Si bien el neoliberalismo, por su naturaleza multiescalar, es asociado a las prácticas de la economía global, su determinación es contextual, y obedece a los rasgos distintivos de cada sitio. En tal sentido, la naturaleza de la relación entre neoliberalismo y transformaciones urbanas, merece un análisis situado al interior de la estructura socioterritorial de cada ciudad y su particular trayectoria. No obstante el evidente efecto homologador que estas prácticas económicas imprimen en la geografía urbana, prescindiendo de consideraciones de latitud o emplazamiento, la ciudad neoliberal expresa sus particulares atributos heredados de su condición de origen, vocación y elección de su destino. En tal sentido, la ciudad de Dubái constituye un caso de estudio interesante, en tanto se caracteriza por un crecimiento urbano dispuesto en unidades singulares demasiado dispersas para articular un modelo territorial reconocible. Tal como Ítalo Calvino relatara metafóricamente en Las ciudades invisibles: “[…] Cada ciudad recibe su forma del desierto al que se opone […]”, en el caso de Dubái su aplicación es literal (Calvino, 1972, p. 13). A través de la exploración documental y observación crítica de campo, se analiza este caso paradigmático de urbanismo neoliberalizado.
Effects of 15 years sludge application on cropland
Authors: Mantovi P. , Baldoni G. , Dal Re L. , Piccinini S. , Rossi L.
Published: March 2020

Sewage sludge effects to cropland have been evaluated in a long-term field experiment which started in 1988 and is still underway in the eastern part of the Po Valley (Italy), on a silty-loam soil. Each autumn municipal-industrial wastewater sludge has been applied at 5 and 10 Mg DM ha-1 yr-1 as anaerobically digested slurry (liquid), belt filtered material (dewatered) and composted with wheat straw, on a winter wheat - maize - sugar beet rotation.

The 15 years continuous application of sludge significantly increased organic matter, total N, Olsen P, Cu and Zn content in the topsoil, with greater effects at the highest rate. Composted sludge favoured the highest OM topsoil increase. Sludge spreading improved soil fertility and crop yields, but it was associated with possible negative environmental effects: on water, due to increased phosphorus availability, and on soil ecology, due to zinc build up in the topsoil.

The results confirmed that compulsory application rates based on real crop nitrogen requirements and matching Nitrate EU Directive, undoubtedly can guarantee a sound sustainability in sewage sludge recycling on cropland in the long run.
Evaluation of the Hydraulic Performance of the Regional Sewer Network of the Greater Tel-Aviv Metropolitan Area (Israel)
Authors: Geller Y. , Zimmerman R. , Friedler E.
Published: March 2020

This paper describes a study of the hydraulic performance of the regional sewer network of greater Tel-Aviv. The network, which is 60 Km long, serves 1.8 million people in 24 municipalities with an average flow of 340,000 m3-d-1. The study is comprised of two stages: a sampling campaign that lasted for several months followed by a simulation stage that revealed the hydraulic performance of the whole sewer network. The paper describes the methodology of the study and the results that showed that only limited segments of the network are at their full capacity and should be replaced immediately. These segments are situated at the upper end of the network. The final part of the paper discusses the contribution of the information gained by the study to the engineering department who runs the network.
On-line survey and diagnose of sewer networks
Authors: Manic G. , Bernardin R. , Salic C. , Blanchet F. , Zug M.
Published: March 2020

Optimal maintenance strategies of sewer networks require an important work force as well as strong experience and knowledge. To ensure both a complete survey of the network and real time estimation of the current state of the network is necessary. A project was started in order to develop a new decision support tool for sewer managers. A new sensor measuring water level was first developed combining four major characteristics: a good resistance to corrosive atmosphere, long term autonomy, reduced cost and the ability to transfer data using radio waves. Further, a deployment campaign of these sensors was undertaken involving 100 sensors coupled with the commissioning of a wireless data transfer system. Finally, a decision support tool was developed to treat the data provided by the sensors to reach three aims: detect drifts, estimate the amount of parasite water and inflow during rainy days, and report any alarms. The pilot site chosen for this program is a main sanitary sewer of the city of Toulouse (France). This article presents the complete methodology, including the development of the decision support tool, as well as the difficulties met and the first results obtained in term of rehabilitation strategies of the network.
Enhanced biological treatment of a residual oil processing plant wastewater by a membrane-bioreactor for effluent quality improvement in a Hungarian refinery
Authors: Keresztényi I. , Kicsi G. , Dobolyi Cs. , Isaák Gy.
Published: March 2020

A 160-day-long preliminary laboratory scale MBR treatment study and the performance test of a new 480 m3/day capacity full scale plant for quality improvement of effluent from a bitumen plant off-gas scrubbing followed by dissolved air flotation were conducted. Two testing periods were distinguished during the laboratory study, specifically the first with 100 days SRT and the second with 50 days SRT. To evaluate the possibility of the organic matter removal enhancement at the end of each testing period powdered activated carbon (PAC) treatment was carried out.

The COD and oil & grease removal efficiency of the well acclimated MBR sludge was greater than 90% and 98%, respectively. The COD content of the treated wastewater during the full scale performance test period was reduced below 100 mg·L−1. To ensure an optimal treatment process, the organic loading rate should be kept in 1.5 – 3 kg COD m−3 d−1 range. and optimal biomass concentration of 10-15 g·L−1 should be ensured to reduce the cleaning frequency of the membrane ultrafilters. To avoid exceedance of compliance with respect to the discharge criteria, further treatment step(s) should be considered prior to any treated wastewater reuse.
Optimization of Compressible Medium Filter for Secondary Effluent Filtration
Authors: Caliskaner O. , Tchobanoglous G.
Published: March 2020

Several innovative filtration technologies have been developed in the last two decades to decrease the backwash requirements, to increase the water production efficiency, and to improve the operational and design conditions. The Compressible Medium Filter (CMF) also known as the “Fuzzy Filter” involves the use of a synthetic compressible fiber (polyvaniladene) porous material as the filtering medium instead of conventional granular material. The optimization of the CMF operation is discussed in this paper. Both the CMF removal performance and backwash water ratio (BWR) increase significantly as the medium compression ratio (MCR) is increased. The optimum MCR (for turbidity removal purposes) is the minimum MCR that results in the required degree of turbidity removal to prevent excessive BWR. The optimum MCR for the filtration of conventional activated sludge secondary effluent (for wastewater reuse application) increases from approximately five percent to 25 percent as the average influent turbidity increases from 4 NTU to 7 NTU. The filtration model developed for CMF application can be used to predict the optimum MCR curves for different and more complex filtration conditions. Chemical requirements are also eliminated or minimized with the CMF technology by increasing the MCR when the influent conditions get worse.
The invisible BNR plant provides high quality effluent and recreational area for densely populated urban area
Authors: Choi E. , Yun Z. , Min K.S.
Published: March 2020

In a densely populated area, a large wastewater treatment plant (WWTP) has been constructed in the underground. The plant is practically “invisible” to visitors and neighbours, and the ground level is used as a park and sport facilities in order to avoid the “not in my backyard” phenomenon. The WWTP has a 5-stage biological nutrient removal system utilizing the denitrifying PAO (dPAO) with a step feed in order to treat the weak sewage with higher nutrient removal requirement. Although the underground installation could be expected to increase plant operating temperature, the temperature increase was only 1°C. The polished final effluent from a sand filter produced average TN and TP concentrations of 5.11 mg/L and 0.91 mg/L, respectively with SS concentrations of 0.61 mg/L, indicating that the dPAO system combined with sand filter effectively produced a high quality effluent.
INTERFERÊNCIAS E INTENCIONALIDADES NA RELAÇÃO HOMEM OBJETO EM SEU TERRITÓRIO UMA ANÁLISE TRANSDISCIPLINAR
Authors: Caon Bittencourt Lizandra
Published: March 2020

São muitas as formas em que o ser humano se relaciona com o mundo e uma delas é a relação homem e objeto. A forma como esta relação irá ocorrer quando um objeto tem potencialidade para ser musealizado, tem grande influencia na história da construção de informação para a humanidade. Este artigo tem por objetivo propor um olhar transdiciplinar a respeito desta relação apresentando duas novas formas de perspectivas. Estas novas formas de divisão são: a relação homem objeto pela interferência e a relação homem objeto pela intencionalidade. Através da junção de conceitos pesquisados em bibliografias da Psicologia, Antropologia, Sociologia e Museologia. Novos paradigmas são apresentados para serem discutidos e pesquisados mais profundamente.
DESENHO DA INFORMAÇÃO NA PERSPECTIVA DA CIÊNCIA DA INFORMAÇÃO
Authors: Ribeiro Nivaldo Calixto , Santos Sarah Rúbia de Oliveira
Published: March 2020

A Ciência da Informação tem apresentado campos de estudo e modelos de compreensão variados. Assim, este trabalho tem como objetivo analisar o conceito de informação na perspectiva da Ciência da Informação. As contribuições teóricas dos autores Saracevic e Wood, Adkinson, Borko, Buckland e Rayward foram adotadas para trilhar a narrativa deste relato. A metodologia adotada é do tipo descritiva e bibliográfica, de abordagem dedutiva baseada em artigos científicos, relatórios técnicos, correspondências por e-mail, obituários, currículos entre outros documentos. Com relação ao conceito “informação”, criou-se um desenho de instrução sintetizado das visões e perspectivas dos autores citados sobre o termo em estudo.
A PRESENÇA DOS AUTORES DAS CIÊNCIAS SOCIAIS E HUMANAS NO CAMPO DA BIBLIOTECONOMIA E DA CIÊNCIA DA INFORMAÇÃO
Authors: Tanus Gabrielle Francinne de S. C. , Aguiar Amanda Ingrid Silva de
Published: March 2020

Apresenta uma análise preliminar das manifestações dos autores das Ciências Sociais e Humanas dentro do campo da Biblioteconomia e da Ciência da Informação (B & C.I.), por meio do método bibliométrico e análise de citação. Com o objetivo de descortinar quais teóricos são convocados para a construção do conhecimento na produção científica dos campos supracitados, realizou-se uma pesquisa exploratória com vistas ao levantamento dos autores das Ciências Sociais e Humanas e, posteriormente, a verificação da ocorrência deles na produção indexada pela Base de Dados em Ciência da Informação (BRAPCI). Foram identificados 180 autores, dos quais 91 apareceram pelo menos uma vez nas buscas empreendidas pelos nomes e sobrenomes desses autores das Ciências Sociais e Humanas. O resultado desta pesquisa demonstrou os dois autores mais citados, Michel Foucault e Pierre Bourdieu, bem como a presença de diversos autores das Ciências Sociais e Humanas na construção do conhecimento da Biblioteconomia e da Ciência da Informação, o que contribui para o fortalecimento e a consolidação de ambas.
Synthesis, Spectroscopic, In-vitro and Computational Analysis of Hydrazones as Potential Antituberculosis Agents: (Part-I)
Authors: Thorat Bapu R. , Rani Deepa , Yamgar Ramesh S. , Mali Suraj N.
Published: March 2020

Background:

Since the last few decades, the healthcare sector is facing the problem of
the development of multidrug-resistant (MDR-TB) and extensively drug-resistant tuberculosis
(XDR-TB) infections all over the world. Regardless of the current healthcare progress for the
treatment of mycobacterial infections, we are still unable to control addition of every year 9 million
new cases of tuberculosis (TB).

Objective:

We had an objective to synthesize some novel hydrazones, which were further subjected
to characterization, Photoluminescence study, in vitro anti-mycobacterium testing and in silico
ADMET predictions.

Methods:

Some new hydrazone derivatives have been successfully prepared by the condensation
reaction in the present study. All the compounds were characterized by using FTIR, NMR, UV,
Fluorescence spectroscopic techniques.

Results:

All our newly synthesized compounds showed strong electronic excitation at 292.6 –
319.0 nm and displayed more intense emissions in the 348 – 365 nm regions except compound 3i.
The newly synthesized hydrazones 3a, 3b, 3f and 3g were found to be the most active compounds
and showed MIC (Minimum inhibitory concentrations) values of 12.5 μg/mL.

Conclusion:

In the realm of development of more potent, effective, safer and less toxic
antituberculosis agents; our current study would definitely help the medicinal chemists to develop
potent analogues containing hydrazine motifs in them.
Preclinical and Clinical Studies on Bryostatins, A Class of Marine-Derived Protein Kinase C Modulators: A Mini-Review
Authors: Raghuvanshi Rinky , Bharate Sandip B.
Published: March 2020

:

Bryostatins are complex macrolactones isolated from marine organisms Bryozoan Bugula neritina. They are potent modulators of protein kinase C isozymes (PKCα: ki = 1.3-188 nM), and are one of the most extensively investigated marine natural products in clinical trials. Although ~21 natural bryostatins have been isolated, however only bryostatin-1 (1) has received much interest among medicinal chemists and clinicians. The structure-activity relationship of bryostatins has been well established, with the identification of key pharmacophoric features important for PKC modulation. The low natural abundance and the long synthetic route have prompted medicinal chemists to come-up with simplified analogs. Bryostatin skeleton comprises three pyran rings connected to each other to form a macrocyclic lactone. The simplest analog 27 contains only one pyran, which is also able to modulate the PKCα activity; however, the cyclic framework appears to be essential for the desired level of potency. Another simplified analog 17 ("picolog") exhibited potent and in-vivo efficacy against lymphoma. Bryostatin-1 (1) has shown an acceptable intravenous pharmacokinetic profile in mice and displayed promising in-vivo efficacy in mice models of various cancers and Alzheimer's disease. Bryostatin-1 was investigated in numerous Phase I/II oncology clinical trials; it has shown minimal effect as a single agent, however, provided encouraging results in combination with other chemotherapy agents. FDA has granted orphan drug status to bryostatin-1 in combination with paclitaxel for esophageal cancer. Bryostatin-1 has also received orphan drug status for fragile X syndrome. Bryostatin-1 was also investigated in clinical studies for Alzheimer's disease and HIV infection. In a nutshell, the natural as well as synthetic bryostatins have generated a strong hope to emerge as treatment for cancer along with many other diseases.
Cryptic Host Defense Peptides: Multifaceted Activity and Prospects for Medicinal Chemistry
Authors: de Oliveira Costa Bruna , Franco Octávio Luiz
Published: March 2020

Host defense peptides (HDPs) comprise a heterogeneous group of evolutionarily conserved and biologically active small molecules that are produced by different organisms. HDPs are widely researched because they often have multiple biological activities, for example antimicrobial, immunomodulatory and anticancer activity. In this context, in this review we focus on cryptic HDPs, molecules derived specifically from proteolytic processing of endogenous precursor proteins. Here, we explore the biological activity of such molecules and we further discuss the development of optimized sequences based on these natural cryptic HDPs. In addition, we present clinical-phase studies of cryptic HDPs (natural or optimized), and point out the possible applicability of these molecules in medicinal chemistry.
123I-FP-CIT Brain SPECT Findings in Succinic Semialdehyde Dehydrogenase (SSADH) Deficiency
Authors: Frantellizzi Viviana , Pontico Mariano , Pani Arianna , De Feo Maria Silvia , De Vincentis Giuseppe
Published: March 2020

Background:

Succinic semialdehyde dehydrogenase (SSADH) deficiency is a rare autosomal
recessive disorder. Neuroimaging findings are commonly considered rather non-specific. To
date, no neuroreceptorial brain imaging with 123I-FP-CIT(DaTScan) is known in subjects with SSADH
deficiency.

Methods:

A 30-year-old man gained our attention to rule out any potential nigrostriatal dopaminergic
presynaptic pathway alterations in a clinical context of a γ-hydroxybutyric aciduria. He showed impossibility
to the autonomous gait, head and trunk retropulsion, lower limbs strength deficit, verbal and
upper limbs motor stereotypies and irregular eye tracking.

Results:

His brain MRI depicted basal ganglia signal abnormalities. Brain SPECT with DaTSCan images
showed a global significant reduction of radiotracer uptake.

Conclusions:

The findings obtained by means of the 123I-DaTScan brain SPECT may give rise to new
concerns on pathophysiological aspects of the SSADH deficiency disorder that has never been investigated
before, such as the nigrostriatal dopaminergic system’s functionality, encouraging further investigation.
The Adoption of Sustainable Facilities Management Practices in Organisations: A study of Malaysian universities
Authors: Hasim Mohamad Sufian , Abdullah Ahmad Sharim , Abdul Rasam Abdul Rauf , Ismail Hafiszah
Published: March 2020

Globally, there is a growing trend among organisations towards promoting sustainability as an essential business strategy due to a high level of awareness about the impacts of their operations on the triple bottom line. This paper aims to examine the implementation of sustainability practices in an organisation focusing on universities. The objective was to determine sustainability adopted in facilities management (FM) practice concerning three different sustainability dimensions. Sixteen (16) interviews were conducted with the senior managerial level in selected universities. Among all dimensions, environmental sustainability was widely focused on having higher priorities for energy efficiency, waste reduction, and water conservation. These results provided some explanation and understanding of the overall picture of the study about organisational commitment towards sustainability in facilities management.Keywords: Sustainable Facilities Management; Malaysian Universities; Sustainable Organisation; Facilities ManagementeISSN: 2398-4287 © 2020. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.DOI: https://doi.org/10.21834/e-bpj.v5i13.1898
Democratic Street: An application of Space Syntax in testing the spatial justice among women pedestrian
Authors: Khalid Nurul Shakila , Nasrudin Na’asah , Abdullah Yusfida Ayu , Che Abdullah Ishak
Published: March 2020

This research examines the quality of streets and public life among women through observation. Axial analysis models are combined into Space Syntax to hypothesize the effect of grid layout on street vitality and sociability in shopping streets by using global and local integration to measure how women use the space. The result indicated that there is a correlation among these parameters with the following spatial configurative analyses; integrated streets attract more women pedestrians and how women feel as well as they use street space.Keywords: Democratic Street; Spatial Justice; Women; Space SyntaxeISSN: 2398-4287 © 2020. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open-access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.DOI: https://doi.org/10.21834/e-bpj.v5i13.1967
Parking Spaces in Taylor’s University: Problems and solutions
Authors: Ibrahim Filzani Illia , Fareez Muhammad , Aishah Myzatul
Published: March 2020

Parking is an essential component of the transportation system. Insufficient parking spaces provided brings many problems to the campus society as well as to the environment such as congestion, high accident rate; shortage of parking spaces, low air quality and high maintenance cost to maintain the transportation infrastructure and facilities. The objective of this paper is to evaluate the satisfaction of the parking facilities provided by Taylor's University hence proposing a solution to the issue. The outcome of this research is to benefit the student and staff that are driving and park their vehicles at Taylors University parking facilities.Keywords: parking; sustainability; facilities managementeISSN: 2398-4287 © 2020. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.DOI: https://doi.org/10.21834/e-bpj.v5i13.2035
An Overview of Creative Placemaking as an Enabler for a Sustainable Urban Regeneration
Authors: Ramli Nurul Atikah , Ujang Norsidah
Published: March 2020

As the rapid growth of cities continues to pose a significant threat to the well-being of people, its adverse effects have moved to the forefront of social sustainability. Urban regeneration has become one of the adaptations in solving a social issue. Alongside these interventions, creative placemaking emerges as an evolving field of practice driving a broader agenda for growth and transformation of cities. This paper reviews the concept of creative placemaking as an approach to urban regeneration and theories extracted from planning and urban design literature. The findings provide an understanding of the significant function of social attributes of place in crafting strategies in the creation of successful creative placemaking.Keywords: Urban regeneration; Creative placemaking; Urban places; Social sustainabilityeISSN: 2398-4287 © 2020. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.DOI: https://doi.org/10.21834/e-bpj.v5i13.2056
Safety Awareness Attitudes among Malaysian Climbers
Authors: Zahir Amier Hazim , Abdul Latif Rozita , Nawi Nor Fadzlina , M.kes Siswantoyo
Published: March 2020

Outdoor recreation gives different project benefits likes gear rental and outdoor exercises. Safety awareness is related to outdoor recreation activities such as climbing and hiking. The objective was divided into three aspects, the relationship between personality and responsible behavior, the relationship between personality and attitudes, and the relationship between safety awareness attitudes and responsible behavior among climbers. This study used a quantitative method that involved 378 climbers of four mountains in Malaysia. The finding indicated that responsible behavior influences personality and a personality influences attitude. It is showed that there was a significant relationship among the climbers.Keywords: safety awareness; personality; attitudes; responsible behavioreISSN: 2398-4287 © 2020. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open-access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer-review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.DOI: https://doi.org/10.21834/e-bpj.v5i13.2097
Температурно-частотная зависимость диэлектрического отклика в мультиферроике LuFe-=SUB=-2-=/SUB=-O-=SUB=-4-=/SUB=-
Authors: Гаджиев Г.М. , Гамзатов А.Г. , Алиев Р.А. , Абакарова Н.С. , Эмирасланова Л.Л. , Маркелова М.Н. , Кауль А.Р.
Published: March 2020

The results of the study of temperature-frequency spectra of the complex dielectric permittivity of the LuFe2O4 multiferroic in the range of temperatures 100 – 400 K and frequencies 20 Hz – 120 MHz are presented. Peculiarities were found in the form of a change in the sign of the temperature coefficient of dielectric constant, as well as in the form of maxima and minima of ac conductivity in the temperature range ~ 150 - 350 K and frequencies ~ 30 - 120 MHz. These features are due to independent resonant mechanisms: coincidence of the frequency of the measuring ac voltage with the frequency of electron hopping during the realization of hopping conduction; the proximity of the period of the measuring signal to the time of formation of the barrier layer at the boundary of contact with the sample; the approximation of the ac frequency of the external field to the frequency of the structural elements of the sample.
Исследование энергетических и магнитных свойств монослойной пленки Fe-=SUB=-x-=/SUB=-Ni-=SUB=-1-x-=/SUB=- на немагнитных металлических подложках
Authors: Мамонова М.В.
Published: March 2020

In the framework of the variational method of the spin density functional theory the formation of a monolayer FexNi1-x alloy film on the W, Ag and Au substrates depending on the concentration of the alloy components and coating parameter is described. The temperature effects of the mixing of adsorbate and substrate atoms and ferromagnetic ordering effects are taken into account. The adsorption energy for a close-packed face is minimal for all presented systems. A monolayer film without mixing is formed on Au and W substrate mainly for large values of the coating parameter and the concentration of iron. For the Ag substrate, the difference in the crystal structure leads to an increase in mixing and the formation of a sandwich similar structure with pushing silver atoms onto the surface. The values of the adsorption energy calculated at T = 0 K in the framework of the variational and first-principle approaches are compared. Calculations of the magnetic moments and exchange integrals for FexNi1-x bulk alloy were carried out using the spin-polarized relativistic Korring-Kohn-Rostoker method. The equilibrium lattice constants were obtained by first-principle calculations. The exchange interaction of the nearest neighbors is ferromagnetic and for heterogeneous nearest neighbors J1Ni-Fe increases with increasing nickel concentration, and for the same type neighbors J1Ni - Ni decreases. The next nearest neighbors exchange interaction is carried out only for atoms of the same type, and for iron, atoms have a ferromagnetic character, while for nickel atoms it is weak antiferromagnetic.
Исследование влияния начальных состояний, анизотропии и дефектов структуры на неравновесное критическое поведение трехмерной модели Гейзенберга
Authors: Прудников В.В. , Прудников П.В. , Лях А.С.
Published: March 2020

A numerical Monte Carlo study of different initial states, magnetic anisotropy of “easy axis” type, and structural defects influence on non-equilibrium critical behavior of the classical three-dimensional Heisenberg model has been carried out. Analysis of time dependence of the magnetization and the autocorrelation function for isotropic Heisenberg model has shown strong influence of initial states on relaxation of the magnetization and aging effects in behavior of the autocorrelation function, which are characterized by anomalous slowing down of relaxation and correlation in system with increasing waiting time. Study of the anisotropic Heisenberg model with magnetic anisotropy of “easy axis” type has revealed that behavior of the magnetization and autocorrelation function in long-time regime is characterized by critical exponents of the three-dimensional Ising model and more fast decay of the autocorrelation function than for isotropic Heisenberg model. It has been revealed that in structurally disordered isotropic Heisenberg model relaxing from the low-temperature initial state, the significant changes of non-equilibrium aging phenomena in comparison with pure model are observed due to the pinning of domain walls on defects. It has been shown that during this relaxation process a strong slowing-down of time dependence of the autocorrelation function is realized. As a result, superaging effects occur in long-term behavior of the autocorrelation function with values of the superaging exponent μ=2.6(1). During evolution of system from high-temperature initial state, the presence of structural defects leads to increase of aging effects in aging regime, but their influence is found irrelevant in long-time regime.
Теплоемкость и магнитокалорический эффект соединений LaFe-=SUB=-11.2-x-=/SUB=-Mn-=SUB=-x-=/SUB=-Co-=SUB=-0.7-=/SUB=-Si-=SUB=-1.1-=/SUB=- (x=0, 0.1, 0.2, 0.3)
Authors: Абдулкадирова Н.З. , Алиев А.М. , Гамзатов А.Г. , Gebara P.
Published: March 2020

The specific heat and magnetocaloric effect of the LaFe11.2-хMnxCo0.7Si1.1 intermetallic compounds (x = 0.1, 0.2, 0.3) were measured in the temperature range 80–300 K and in magnetic fields up to 8 T. The magnetocaloric effect (MCE) was estimated using two methods: direct method in cyclic magnetic fields, as well as an indirect method from heat capacity data. It was shown that an increase in the concentration of Mn atoms leads to a shift in the Curie temperature of the TC toward lower temperatures, while the FM value changes slightly.
Структурные особенности фосфатов Ca-=SUB=-9-x-=/SUB=-M-=SUB=-x-=/SUB=-Dy(PO-=SUB=-4-=/SUB=-)-=SUB=-7-=/SUB=- (M=Zn-=SUP=-2+-=/SUP=-, Mg-=SUP=-2+-=/SUP=-)
Authors: Никифоров И.В. , Дейнеко Д.В. , Дускаев И.Ф.
Published: March 2020

Solid solutions of phosphate with whitlockite-type Ca9-xMxDy (PO4) 7 (M = Zn2 +, Mg2 +) were obtained. The samples were studied by a complex of methods, such as X-ray phase analysis, second harmonic generation, and luminescent spectroscopy. It was established that in the series of solid solutions a change in the symmetry of the unit cell R3c-> R 3c is observed during Ca2+ -M2+ substitution, and the concentration dependence was determined. The phase transitions of the ferroelectric and antiferroelectric type and their temperature position were established by dielectric spectroscopy. The synthesized samples demonstrate intense luminescence with 350 nm excitation and the resulting radiation is in the white region of color coordinates (CIE).
Процессы теплопереноса в мультиферроиках Bi-=SUB=-1-x-=/SUB=-Ho-=SUB=-x-=/SUB=-FeO-=SUB=-3-=/SUB=- (x=0-0.20)
Authors: Каллаев С.Н. , Бакмаев А.Г. , Резниченко Л.А.
Published: March 2020

The thermal diffusivity and thermal conductivity of Bi1-xHoxFeO3 multiferroics (x = 0-0.20) were studied in the high-temperature range 300-1200K. It has been established that alloying with rare earth element with holmium leads to a noticeable increase in heat capacity in a wide temperature range T> 300 K and to a significant change in the temperature anomalies of thermal diffusion and thermal conductivity of the phase transition region. The dominant mechanisms of phonon heat transfer in the region of ferroelectric and antiferromagnetic phase transitions are considered. The dependence of the mean free path on temperature has been determined. Research results are discussed in conjunction with structural studies.
Силицид Mg-=SUB=-2-=/SUB=-Si под давлением: результаты эволюционного поиска из первых принципов
Authors: Луняков Ю.В.
Published: March 2020

First-principles Density Functional Theory (DFT) evolutionary searches were carried out for magnesium silicide Mg2Si structures. The well-known hexagonal structure of P63/mmc symmetry is shown to transform to monoclinic С2/m structure under pressure Р~34 GPa. The last one is stable up to pressures P<76 GPa. The monoclinic structure is changed by orhorhombic structure Pmmm, which is stable up to pressures P~235 GPa, then losing to monoclinic structure с симметрией P2/m. The structural changes under the pressures P63/mmc → С2/m → Pmmm → Р2/m are shown at the atomic levels. Structural phase diagram of the bulk silicide Mg2Si at the pressure range 0–240 GPa is constructed.
Электронные и магнитные свойства сплавов DyFe-=SUB=-4-=/SUB=-Ge-=SUB=-2-=/SUB=- в области фазового перехода
Authors: Матюнина М.В. , Загребин М.А. , Соколовский В.В. , Бучельников В.Д.
Published: March 2020

Abstract The first-principles studies have been performed for the electronic and magnetic properties of DyFe_4Ge_2 alloys near the P 4_2/ mmm – Cmmm phase transition. The calculations are carried out in a local spin density approximation taking into account the Coulomb interaction within the limit of strong localization in a mean field approximation. The electronic and magnetic properties of the tetragonal structure are shown to be weakly changed in the dependence on the Coulomb and exchange interactions and also on the choice of the approximations. In the case of the orthorhombic structure, a change in the parameters of the Coulomb and exchange interactions leads to a change in the magnetic ordering: from the ferromagnetic to ferrimagnetic in the strong localization limit and from the ferromagnetic to paramagnetic in the mean field approximation.
Влияние магнитомягкой фазы на процессы перемагничивания магнитотвердого/магнитомягкого бислоя
Authors: Тааев Т.А. , Хизриев К.Ш. , Муртазаев А.К.
Published: March 2020

Investigation of the magnetization reversal of a hard/soft magnetic bilayer in an external magnetic field was performed by the Monte Carlo method. The magnetization reversal curves of the magnetic bilayer are plotted for various values of the thickness of the soft magnetic layer. Also the effect of the intralayer exchange interaction and the anisotropy constant on the magnetization reversal processes was studied. The phase diagrams of the magnetic bilayer are plotted.
Компьютерное моделирование фазовых переходов и критических свойств фрустрированной модели Гейзенберга на кубической решетке
Authors: Рамазанов М.К. , Муртазаев А.К.
Published: March 2020

The phase transitions and critical properties of the Heisenberg antiferromagnetic model on a cubic lattice with nearest and next-nearest-neighbor interactions are investigated by the replica Monte Carlo method. The range of values of the interaction of the next-nearest-neighbor is considered 0.0 ≤ r ≤ 1.0. The phase diagram relating the transition temperature and the magnitude of next-nearest neighbor interactions is constructed. It is shown that a second order phase transition occurs in the r range under study. The values of all the main static critical exponents are calculated by means of the finite-size scaling theory. It is shown that the universality class of the critical behavior of this model is preserved in the range of 0.0 ≤ r ≤ 0.4.