bluuebunny/crossref_metadata_2025 huggingface dataset:
miRNA Expression and Interaction with Genes Involved in Susceptibility to Pristane-Induced Arthritis
Authors: Fernandes Jussara Gonçalves , Borrego Andrea , Jensen José Ricardo , Cabrera Wafa Hanna Koury , Correa Mara Adriana , Starobinas Nancy , Ribeiro Orlando Garcia , Ibañez Olga Martinez , De Franco Marcelo
Published: December 2018

Pristane-induced arthritis (PIA) in mice is an experimental model that resembles human rheumatoid arthritis, a chronic autoimmune disease that affects joints and is characterized by synovial inflammation and articular cartilage and bone destruction. AIRmax and AIRmin mouse lines differ in their susceptibility to PIA, and linkage analysis in this model mapped arthritis severity QTLs in chromosomes 5 and 8. miRNAs are a class of small RNA molecules that have been extensively studied in the development of arthritis. We analyzed miRNA and gene expression profiles in peritoneal cells of AIRmax and AIRmin lines, in order to evaluate the genetic architecture in this model. Susceptible AIRmax mice showed higher gene (2025 vs 1043) and miRNA (240 vs 59) modulation than resistant AIRmin mice at the onset of disease symptoms. miR-132-3p/212-3p, miR-106-5p, miR-27b-3p, and miR-25-3p were among the miRNAs with the highest expression in susceptible animals, showing a negative correlation with the expression of predicted target genes (Il10, Cd69, and Sp1r1). Our study showed that global gene and miRNA expression profiles in peritoneal cells of susceptible AIRmax and resistant AIRmin lines during pristane-induced arthritis are distinct, evidencing interesting targets for further validation.
Achieving of High Density/Utilization of Active Groups via Synergic Integration of C=N and C=O Bonds for Ultra-Stable and High-Rate Lithium-Ion Batteries
Authors: Sun Tao , Li Zong-Jun , Zhang Xin-Bo
Published: December 2018

Organic electrode materials are receiving ever-increasing research interest due to their combined advantages, including resource renewability, low cost, and environmental friendliness. However, their practical applications are still terribly plagued by low conductivity, poor rate capability, solubility in electrolyte, and low density/utilization of active groups. In response, herein, as a proof-of-concept experiment, C=N and C=O bonds are synergically integrated into the backbone of pentacene to finely tune the electronic structures of pentacene. Unexpectedly, the firstly obtained unique 5,7,11,14-tetraaza-6,13-pentacenequinone/reduced graphene oxide (TAPQ/RGO) composite exhibits superior electrochemical performances, including an ultra-stable cycling stability (up to 2400 cycles) and good rate capability (174 mAh g
−1
even at a high current density of 3.2 A g
−1
), which might be attributed to the abundant active groups,
π
-conjugated molecular structure, leaf-like morphology, and the interaction between TAPQ and graphene.
Continuous Blood Pressure Estimation Based on Two-Domain Fusion Model
Authors: Wang Qian , Xu Yajie , Zeng Guoqiang , Sun Mingshan
Published: December 2018

Blood pressure (BP) is one of the indispensable elements of physiological health characteristics and a significant indicator for predicting and diagnosing hypertension and cardiovascular diseases. This paper proposes a two-domain fusion model to estimate BP continuously from pulse wave acquired with a pressure sensor. Method. The optimal external pressure applied on the pressure sensor is first determined in order to capture pulse wave in the radial artery. The captured pulse wave is then processed in both the time and frequency domains via filtering and fast Fourier transform. Finally, a set of features are extracted from these two domains and input into a neural network along with blood pressure values measured by a commercial sphygmomanometer for training. The model is then tested on new data for accuracy evaluation. Results. The proposed two-domain fusion method achieved a high degree of accuracy in measuring blood pressure.
Research on Sparsity of Output Synapses in Echo State Networks
Authors: Mu Xiaohui , Li Lixiang , He Xiangyu
Published: December 2018

This paper presents an improved model of echo state networks (ESNs) and gives the definitions of energy consumption, energy efficiency, etc. We verify the existence of redundant output synaptic connections by numerical simulations. We investigate the relationships among energy consumption, prediction step, and the sparsity of ESN. At the same time, the energy efficiency and the prediction steps are found to present the same variation trend when silencing different synapses. Thus, we propose a computationally efficient method to locate redundant output synapses based on energy efficiency of ESN. We find that the neuron states of redundant synapses can be linearly represented by the states of other neurons. We investigate the contributions of redundant and core output synapses to the performance of network prediction. For the prediction task of chaotic time series, the predictive performance of ESN is improved about hundreds of steps by silencing redundant synapses.
A Privacy‐Preserving Spatial Index for Spatial Query Processing
Authors: Song Doohee , Song Moonbae , Park Kwangjin
Published: December 2018

An increasing amount of active research is being conducted to protect the locations of mobile device users. Users must tune to more data than they would like to in order to hide their location. In particular, if a user requests a query over kNN, the number of objects the user must receive may increase. Several studies have been proposed to solve these problems. However, problems have been identified during the course of query processing, such as errors and increased query processing times. When the tuning time is increased, the amount of data to download and the battery consumption of the client also increase. In this study, we propose the Privacy‐preserving Spatial Index (PSI), an index that allows users to reduce their tuning time while being satisfied with the results of their queries. The querier (q) requests the object in the area protecting his/her location from the server. The server sends the requested data of points of interest (POIs) (DPOIs) in the Privacy‐preserving Region (PR) to q. Finally, q reduces tuning time by selectively tuning to the desired data of POIs (Dw) through PSI. The superiority of PSI over previous techniques is experimentally proven.
Effect of Energy Development and Technological Innovation on PM2.5 in China: A Spatial Durbin Econometric Analysis
Authors: Liu Xiaohong
Published: December 2018

Using the panel data of 29 provinces and regions in China, this paper analyzes the temporal and spatial characteristics of PM2.5 concentration. The spatial Durbin model is used to empirically examine the impact of energy development and technological innovation on PM2.5. The results show that the interprovincial PM2.5 in China showed an inverted “N” trend. There is a spatial agglomeration of interprovincial PM2.5, and the spatial autocorrelation is significant. The spatial autoregression coefficients of adjacent weights and distance weights are significantly positive, and PM2.5 pollution in adjacent areas has a positive effect on the region. From the view of energy development, the increase in energy intensity will significantly increase the concentration of PM2.5 in adjacent areas, which will increase the global PM2.5 concentration. The increase in the proportion of coal consumption increases the concentration of PM2.5 in the region and globally. The increase in energy consumption prices will reduce the PM2.5 concentration in the region and globally. From the view of technological innovation, the increase in sales revenue of new products of industrial enterprises above the scale will reduce the concentration of PM2.5 in the region by 0.1285 percentage points and the concentration of PM2.5 in adjacent areas by 0.3058 percentage points, which will reduce the global PM2.5 concentration by 0.4343 percentage points. The increase in the number of granted patent applications will reduce the PM2.5 concentration of the adjacent regions and globally. The increasing level of infrastructure for technological innovation in the region will reduce the concentration of PM2.5 in adjacent areas. The increase in technical market turnover will reduce the concentration of PM2.5 in the region and the concentration of PM2.5 in adjacent areas, which will reduce the global PM2.5 concentration. In order to reduce the concentration of PM2.5 in China, we should continue to promote PM2.5 regional collaborative governance. In terms of energy development, it is necessary to reduce energy intensity, optimize energy structure, implement energy substitution, and rationalize energy prices. In terms of technological innovation, it is essential to increase sales revenue of new products of industrial enterprises, raise number of granted patent applications, vigorously improve level of infrastructure for technological innovation, and enhance technical market turnover.
Toll‐Like Receptor 4–Myeloid Differentiation Primary Response Gene 88 Pathway Is Involved in the Shikonin Treatment of CIA by Regulating Treg/Th17 Expression
Authors: Dai Qiaomei , Li Ji , Yun Yu , Wang Jianwei
Published: December 2018

Objective. To investigate the effect of shikonin on (CIA) collagen‐induced arthritis and its influence and mechanism on the balance between Th17 cells and Treg cells. Methods. Three doses of shikonin were administered orally to mice before the onset of CIA, and celecoxib was used as positive control drug. The arthritis response was monitored visually by macroscopic scoring and hindpaw swelling. Histology of knee was used to assess the occurrence of cartilage destruction and bone erosion. Serum collagen type II (C II) antibody levels associated with CIA were assessed with ELISAs. RT‐PCR and quantitative PCR were employed to determine the mRNA expression of cytokines and TLRs in the surface of DCs in the patella with adjacent synovium and spleen in CIA. The expression of cytokines and transcription factors in the peripheral immune organs was tested by Western blotting. Results. Shikonin treatment suppressed the macroscopic score and incidence of arthritis. Swelling of hind paws, cartilage destruction, and serum anti‐C II concentration were delayed with shikonin when compared to controls. Shikonin treatment suppressed the arthritis in a dose‐dependent manner. Moreover, the expression of Th17 cytokines (IL‐17A) was greatly inhibited both in the synovium and spleen in treated groups compared with those in control groups. The mRNA and protein levels of IL‐10 and TGF‐β, however, were upregulated after shikonin treatment. The expression of Foxp3 in the synovium and spleen was upregulated, and the expression of ROR‐γt in the synovium and spleen was downregulated after shikonin treatment through RT‐PCR, quantitative PCR, and Western blotting. The DCs in the spleen of shikonin‐treated mice had lower expression of TLR4 and MyD88, and the expression of TLR2 and TLR9 in the spleen was not different between the two groups. Conclusion. Shikonin has anti‐inflammatory effects on CIA. Shikonin treatment can inhibit Th17 cytokines expression and induce Treg responses through inhibiting the activation of TLR4/MyD88 pathway.
Tight Junction in the Intestinal Epithelium: Its Association with Diseases and Regulation by Phytochemicals
Authors: Lee Bonggi , Moon Kyoung Mi , Kim Choon Young
Published: December 2018

The intestine plays an essential role in integrating immunity and nutrient digestion and absorption. Adjacent intestinal epithelia form tight junctions (TJs) that are essential to the function of the physical intestinal barrier, regulating the paracellular movement of various substances including ions, solutes, and water across the intestinal epithelium. Studies have shown that TJ dysfunction is highly associated with metabolic and inflammatory diseases. Thus, molecular and nutritional factors that improve TJ activity have gained attention in the pharmaceutical and medicinal fields. This review focuses on the association between TJ and diverse pathological conditions, as well as various molecular and nutritional interventions designed to boost TJ integrity.
Visual-Evoked-Response-Supported Outcome of Intravitreal Erythropoietin in Management of Indirect Traumatic Optic Neuropathy
Authors: Rashad Mohammad Ahmad , Abdel Latif Ahmed Abdel Meguid , Mostafa Hazem A. , Fawzy Samah Mahmoud , Abdel Latif Mahmoud Abdel Meguid
Published: December 2018

Purpose. Investigating the efficacy of intravitreal injection of erythropoietin (EPO) in managing indirect traumatic optic neuropathy (ITON) of different durations.Methods. A case series that included two groups of ITON patients: recent ITON group (<3 months trauma duration; 7 eyes) and old duration ITON group (3–36 months; 7 eyes). Diagnostic computerized tomography (CT) and baseline flash visual evoked response (VER) were performed at the presentation time. At the initial visit and each follow-up, all patients had undergone assessment of best-corrected visual acuity (BCVA), pupil reaction, and anterior and posterior segments. VER was repeated 1 and 3 months after injection. All patients received an intravitreal injection of 2000 IU EPO in 0.2 ml of commercially available sterile EPREX 4000 solution, Jansen Cilag, Zug, Switzerland. Five patients had received a second injection 3 months later.Results. Significant improvement was found in BCVA, VER amplitude, and latency (P<0.0001, 0.0154, and 0.0291, respectively). Initial values of BCVA, VER amplitude, and latency correlated significantly to the final values. Differences between recent and old trauma groups were insignificant in the three parameters. In patients who received second injection, further clinical but statistically insignificant improvement was noted in BCVA in 60% of patients, VER amplitude in 50% of patients, and in VER latency in 100% of patients. No complications were recorded.Conclusion. Intravitreal injection of EPO may be effective and safe in treatment of recent and old indirect traumatic optic neuropathy.
Intravoxel Incoherent Motion (IVIM) Diffusion-Weighted Imaging (DWI) in Patients with Liver Dysfunction of Chronic Viral Hepatitis: Segmental Heterogeneity and Relationship with Child-Turcotte-Pugh Class at 3 Tesla
Authors: Ding Lei , Xiao Lianxiang , Lin Xiangtao , Xiong Chunmei , Lin Lingbo , Chen Shijun
Published: December 2018

Background. Few studies focused on the region of interest- (ROI-) related heterogeneity of liver intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI). The aim of the study was to evaluate the differences of liver IVIM parameters among liver segments in cirrhotic livers (chronic viral hepatitis).Material and Methods. This was a retrospective study of 82 consecutive patients with chronic liver disease who underwent MRI examination at the Jinan Infectious Diseases Hospital between January 2015 and December 2016. IVIM DWI (seven differentbvalues) was performed on a Siemens 3.0-T MRI scanner. Pure molecular diffusion (D), pseudodiffusion (D∗), and perfusion fraction (f) in different liver segments were evaluated.Results.f,D, andD∗were different among the liver segments (allp<0.05), indicating heterogeneity in IVIM parameters among liver segments.fwas consistently higher in Child-Turcotte-Pugh (CTP) class A compared with CTP class B + C (p<0.01).DandD∗were higher in CTP class A compared with CTP class B + C (p<0.05). In patients with meanfvalue of >0.29, the AUC was 0.88 (95% CI: 0.81-0.96), with 86.8% sensitivity and 81.8% specificity for predicting CTP class A from CTP class B + C.Conclusion. Liver IVIM could be a promising method for classifying the severity of segmental liver dysfunction of chronic viral hepatitis as evaluated by the CTP class, which provides a noninvasive alternative for evaluating segmental liver dysfunction with accurate selection of ROIs. Potentially it can be used to monitor the progression of CLD and LC in the future.
Optimizational Mathematical Modeling Methods of DC Traction Power Supply System for Urban Mass Transit
Authors: Shang Jing , Zhang Jie , Zhang Zhixue
Published: December 2018

Time-varying characteristics of DC traction power supply system network structure are the key technical problem in its mathematical modeling. Based on node admittance network equation theory, this paper puts forward an optimizational mathematical modeling method of DC traction power supply system for urban mass transit, and that is to conduct automatic sequencing firstly for all the nodes on both ends of traction substation and the train according to the given rules, then arrange the nodes according to the position coordinates and save them into the arrays, and finally generate the node admittance network equation of DC traction power supply system according to the self-adaptive real-time dynamics of node arrays and input parameter documents. Simulation study indicates the rationality and correctness of optimizational mathematical modeling method of DC traction power supply system for urban mass transit.
Inflation in f(R,ϕ) Gravity with Exponential Model
Authors: Kousar Farzana , Saleem Rabia , Zubair M.
Published: December 2018

We are taking action of f(R) gravity with a nonminimal coupling to a massive inflaton field. A f(R,ϕ) model is chosen which leads to the scalar-tensor theory which can be transformed to Einstein frame by conformal transformation. To avoid the vagueness of the frame dependence, we evaluate the exact analytical solutions for inflationary era in Jordan frame and find a condition for graceful exit from inflation. Furthermore, we calculate the perturbed parameters (i.e., number of e-folds, slow-roll parameters, scalar and tensor power spectra, corresponding spectral indices, and tensor to scalar ratio). It is showed that the tensor power spectra lead to blue tilt for this model. The trajectories of the perturbed parameters are plotted to compare the results with recent observations.
Degalactotigonin, a Steroidal Glycoside from Solanum nigrum, Induces Apoptosis and Cell Cycle Arrest via Inhibiting the EGFR Signaling Pathways in Pancreatic Cancer Cells
Authors: Tuan Anh Hoang Le , Tran Phuong Thao , Thao Do Thi , Trang Duong Thu , Dang Nguyen Hai , Van Cuong Pham , Kiem Phan Van , Minh Chau Van , Lee Jeong-Hyung
Published: December 2018

Degalactotigonin (1) and three other steroidal compounds solasodine (2), O-acetyl solasodine (3), and soladulcoside A (4) were isolated from the methanolic extract of Solanum nigrum, and their chemical structures were elucidated by spectroscopic analyses. The isolated compounds were evaluated for cytotoxic activity against human pancreatic cancer cell lines (PANC1 and MIA-PaCa2) and lung cancer cell lines (A549, NCI-H1975, and NCI-H1299). Only degalactotigonin (1) showed potent cytotoxicity against these cancer cell lines. Compound 1 induced apoptosis in PANC1 and A549 cells. Further study on its mechanism of action in PANC1 cells demonstrated that 1 significantly inhibited EGF-induced proliferation and migration in a concentration-dependent manner. Treatment of PANC1 cells with degalactotigonin induced cell cycle arrest at G0/G1 phase. Compound 1 induced downregulation of cyclin D1 and upregulation of p21 in a time- and concentration-dependent manner and inhibited EGF-induced phosphorylation of EGFR, as well as activation of EGFR downstream signaling molecules such as Akt and ERK.
Differential Associations for Salivary Sodium, Potassium, Calcium, and Phosphate Levels with Carotid Intima Media Thickness, Heart Rate, and Arterial Stiffness
Authors: Labat Carlos , Thul Silke , Pirault John , Temmar Mohamed , Thornton Simon N. , Benetos Athanase , Bäck Magnus
Published: December 2018

Salivary biomarkers may offer a noninvasive and easy sampling alternative in cardiovascular risk evaluation. The aim of the present study was to establish associations of salivary potassium, sodium, calcium, and phosphate levels with the cardiovascular phenotype determined by carotid ultrasound and carotid-femoral pulse wave velocity and to identify possible covariates for these associations. N=241 samples of nonstimulated whole buccal saliva were obtained from subjects with (n=143; 59%) or without (n=98; 41%) hypertension. The potassium concentrations were 10-fold higher in saliva compared with plasma, whereas sodium concentrations exhibited the reverse relation between saliva and blood. There were no significant correlations between the levels of sodium, potassium, or calcium in saliva and plasma. All salivary electrolytes, except sodium, were significantly associated with age. In age-adjusted analyses, salivary potassium was significantly associated with carotid artery intima media thickness (cIMT) and carotid-femoral pulse wave velocity, and these associations were at the limit of significance in multivariate analyses including prevalent cardiovascular disease and risk factors. Body mass index was a significant confounder for salivary potassium. Salivary phosphate was significantly associated with cIMT in the multivariate analysis. Salivary potassium, calcium, and phosphate levels were significantly associated with heart rate in the univariate age-adjusted as well as in two different multivariate models, whereas no significant associations between sodium and heart rate were observed. In conclusion, the differential association of salivary electrolytes with cardiovascular phenotypes indicates that these electrolytes should be further studied for their predictive value as noninvasive biomarkers for cardiovascular risk evaluation.
Conservative Management of Dental Erosion in Adolescents with Medical Conditions
Authors: Mohd Nor Hikmah , Harun Nor Asilah
Published: December 2018

The prevalence of dental erosion among children and adolescents is trending higher in recent decades and is becoming a major concern. Dental erosion can be caused by either extrinsic or intrinsic acids or both. One of the established aetiological factors for dental erosion by intrinsic acid is the gastrooesophageal reflux disease. The degree of dental erosions may be influenced by any medical conditions that cause a reduction in salivary flow such as the salivary gland excision, autoimmune disease, radiation to the head and neck regions, and medications. If left untreated, the dental erosion can cause dentine hypersensitivity, loss of occlusal vertical height, and aesthetic problems. For effective management of dental erosion, the aetiology of each case must be determined, and its detection at an early stage is of prime importance. This case report illustrates the conservative management of dental erosion in two adolescent patients presented with their medical conditions and behaviour issues. The aim of the treatments was to preserve the vitality of the affected teeth. The treatments were successfully completed using a conservative approach, with the patients’ medical conditions taken into consideration.
A New Model Based on 25-Hydroxyvitamin D3 for Predicting Active Crohn’s Disease in Chinese Patients
Authors: Lin Sinan , Wang Ying , Li Li , Chen Peng , Mao Ren , Feng Rui , Qiu Yun , He Yao , Chen Baili , Zeng Zhirong , Chen Minhu , Zhang Shenghong
Published: December 2018

Background. The association between vitamin D3 and activity of Crohn’s disease (CD) is unclear in Chinese patients. In this study, we aimed to evaluate the correlations between serum levels of 25-hydroxyvitamin D3 (25(OH)D3) and disease activity and predict active disease based on vitamin D status. Methods. Between January 2014 and December 2017, 346 CD patients from the First Affiliated Hospital of Sun Yat-sen University were recruited and categorized into a group with 25(OH)D3 ≤ 20 ng/ml and a group with 25(OH)D3 > 20 ng/ml. The clinical characteristics, medication, and health-care needs were compared between the groups. The correlations among 25(OH)D3 and routine serum biomarkers and disease activity were examined. The predictive efficiency of 25(OH)D3 and other biomarkers for active diseases was also explored using receiver-operating characteristic (ROC) curve analysis. A new predictive model, −5∗25OHD3+2∗Hb+ESR, and a nomogram were established using Logistic Regression. Results. Patients with 25(OH)D3 ≤ 20 ng/ml had higher serum levels of C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and platelets (PLT) and lower levels of hemoglobin (Hb) and albumin (ALB). Serum levels of 25(OH)D3 were inversely correlated with the score of Crohn’s Disease Activity Index (CDAI) (rs=−0.608). ROC analysis showed a better predictive value of −25(OH)D3 and the new model with areas under curve (AUC) of 0.804 and 0.879, respectively, than those of CRP (0.693) and ESR (0.713) in disease activity. A nomogram for prediction was established with a c-index of 0.882. Conclusions. Serum levels of 25(OH)D3 negatively correlated with CD activity in Chinese patients. The new model and a nomogram based on 25(OH)D3 showed a better efficiency in predicting disease activity in CD patients but warrants further study.
Involvement of M1 Macrophage Polarization in Endosomal Toll-Like Receptors Activated Psoriatic Inflammation
Authors: Lu Chih-Hao , Lai Chao-Yang , Yeh Da-Wei , Liu Yi-Ling , Su Yu-Wen , Hsu Li-Chung , Chang Chung-Hsing , Catherine Jin S.-L. , Chuang Tsung-Hsien
Published: December 2018

Psoriasis is a chronic inflammatory skin disorder that affects ~2%–3% of the worldwide population. Inappropriate and excessive activation of endosomal Toll-like receptors 7, 8, and 9 (TLRs 7–9) at the psoriatic site has been shown to play a pathogenic role in the onset of psoriasis. Macrophage is a major inflammatory cell type that can be differentiated into phenotypes M1 and M2. M1 macrophages produce proinflammatory cytokines, and M2 macrophages produce anti-inflammatory cytokines. The balance between these two types of macrophages determines the progression of various inflammatory diseases; however, whether macrophage polarization plays a role in psoriatic inflammation activated by endosomal TLRs has not been investigated. In this study, we investigated the function and mechanism of macrophages related to the pathogenic role of TLRs 7–9 in the progression of psoriasis. Analysis of clinical data in database revealed significantly increased expression of macrophage markers and inflammatory cytokines in psoriatic tissues over those in normal tissues. In animal studies, depletion of macrophages in mice ameliorated imiquimod, a TLR 7 agonist-induced psoriatic response. Imiquimod induced expression of genes and cytokines that are signature of M1 macrophage in the psoriatic lesions. In addition, treatment with this TLR 7 agonist shifted macrophages in the psoriatic lesions to a higher M1/M2 ratio. Both of the exogenous and endogenous TLR 7–9 ligands activated M1 macrophage polarization. M1 macrophages expressed higher levels of proinflammatory cytokines and TLRs 7–9 than M2 macrophages. These results suggest that by rendering macrophages into a more inflammatory status and capable of response to their ligands in the psoriatic sites, TLR 7–9 activation drives them to participate in endosomal TLR-activated psoriatic inflammation, resulting in an amplified inflammatory response. Our results also suggest that blocking M1 macrophage polarization could be a strategy which enables inhibition of psoriatic inflammation activated by these TLRs.
Hepatoprotective Effect of Eriobotrya japonica Leaf Extract and Its Various Fractions against Carbon Tetra Chloride Induced Hepatotoxicity in Rats
Authors: Shahat Abdelaaty A. , Ullah Riaz , Alqahtani Ali S. , Alsaid Mansour S. , Husseiny Husseiny A. , Al Meanazel Osaid T. R.
Published: December 2018

Eriobotrya japonica is traditionally used as an antipyretic, digestive, and diuretic agent. Its flowers possess free radical–scavenging, antioxidative, and hepatoprotective effects. We investigated the hepatoprotective potential of E. japonica leaf extract and its various fractions against hepatotoxicity in rats. Liver injury was stimulated by the oral administration of carbon tetrachloride (CCl4; 2.5 mL/kg b.wt.). Male albino rats (n = 55) were distributed arbitrarily into 11 groups: Group I, normal control group; Group II, CCl4 (positive control group); Group III, CCl4 + silymarin; Groups IV and V, CCl4 + two doses of 250 and 500 mg/kg of the 80% methanolic extract of E. japonica leaves, respectively; Groups VI and VII, CCl4 + 250 mg/kg and 500 mg/kg of the ethyl acetate fraction, respectively; Groups VIII and IX, CCl4 + 250 and 500 mg/kg of the butanol fraction, respectively; and Groups X and XI, CCl4 + 250 and 500 mg/kg of the aqueous fraction of E. Japonica leaves, respectively. CCl4‐treated rats that were given 250 or 500 mg/kg of the methanol extract of E. Japonica leaves, or its ethyl acetate, butanol, or aqueous fractions, had significantly lower levels of biochemical parameters such as alanine aminotransferase, aspartate transaminase, alkaline phosphate, total protein, gamma‐glutamyl transferase, and bilirubin levels than those of the CCl4positive group. However, the extract and fractions did not significantly affect lipid profiles. Thus, we conclude that Eriobotrya leaf extract and its fractions have a hepatoprotective effect against CCl4‐induced hepatotoxicity in rats.
Gynecologists May Underestimate the Amount of Blood Loss during Total Laparoscopic Hysterectomy
Authors: Sato Masakazu , Koizumi Minako , Inaba Kei , Takahashi Yu , Nagashima Natsuki , Ki Hiroshi , Itaoka Nao , Ueshima Chiharu , Nakata Maki , Hasumi Yoko
Published: December 2018

Background. We considered the possibility of underestimation of the amount of bleeding during laparoscopic surgery, and we investigated comparing the amount of bleeding between laparoscopic surgery and open surgery by considering the concentration of hemoglobin before and after surgery as indicators. Methods. The following procedures were included: A, surgery for ovarian tumor; B, myomectomy; and C, hysterectomy either by laparoscopic surgery or open surgery. Patients who underwent the above procedures in between January 1, 2010, and December 31, 2017, were enrolled. We identified 1749 cases (A: 90, B: 105, and C: 325 of open surgery and A: 667, B: 437, and C: 125 of laparoscopic surgery). We considered the sum as an estimation of blood loss during surgery and the change in the value of hemoglobin in laboratory testing one day before and after surgery. Results. During laparoscopic surgery, the measurements of blood loss included the following: A: 59.8 ml; B: 168.6 ml; and C: 206.8 ml. During open surgery, measurements of blood loss included the following: A: 130.7 ml; B: 236.7 ml; and C; 280.9 ml. The reduction of hemoglobin after surgery compared with that before surgery was less in laparoscopic surgery than that in open surgery in A and B; however, this reduction was not significantly different in C. Conclusion. Our results suggest that the estimation of the bleeding in A and B was appropriate; however, the estimation might be underestimated in C during laparoscopic surgery.
Kaempferia parviflora and Its Methoxyflavones: Chemistry and Biological Activities
Authors: Chen Dalin , Li Hongliang , Li Wen , Feng Shuo , Deng Dingsen
Published: December 2018

Kaempferia parviflora (KP), a health‐promoting herb, has been traditionally used for treating a variety of diseases. Pharmacological studies have claimed the various benefits from KP and its main effective methoxyflavones, including cellular metabolism‐regulating activity, anticancer activity, vascular relaxation and cardioprotective activity, sexual enhancing activity, neuroprotective activity, antiallergic, anti‐inflammatory, and antioxidative activity, antiosteoarthritis activity, antimicroorganism activity, and transdermal permeable activity. These might be associated with increased mitochondrial functions and activated cGMP‐NO signaling pathway. However, the underlying molecular mechanisms of KP and its methoxyflavones are still under investigation. The clinical applications of KP and its methoxyflavones may be limited due to their low bioavailability. But promising strategies are on the way. This review will comprehensively discuss the biological activities of KP and its methoxyflavones.
Optimum Oil Palm Shell Content as Coarse Aggregate in Concrete Based on Mechanical and Durability Properties
Authors: Maghfouri Mehdi , Shafigh Payam , Aslam Muhammad
Published: December 2018

Oil palm shell (OPS) is a biosolid waste in palm oil industry in the tropical countries which could be used as aggregate in concrete mixture. Since 1984, OPS has been experimented as natural lightweight aggregate in research studies to produce lightweight concrete (LWC). Medium and high‐strength LWCs using OPS as coarse aggregate were successfully produced. However, higher drying shrinkage and lower mechanical properties for concretes containing higher volume of OPS are reported in previous studies. Therefore, OPS is not fit to be used as full coarse aggregate in concrete mixture and therefore, there should be an optimum OPS content in concrete. In this study, in a normal‐weight concrete, normal coarse aggregate was replaced with OPS from zero to 100% with an interval of 20%. Tests such as slump, density, compressive strength in different curing conditions, splitting tensile strength, initial and final water absorptions, and drying shrinkage of cured and uncured specimens were conducted to find out optimum OPS content in concrete. From the test results, it could be summarized that OPS content should not exceed 60% of total volume of coarse aggregate.
From the Difference of Structures to the Structure of the Difference
Authors: Zanin Massimiliano , Menasalvas Ernestina , Sun Xiaoqian , Wandelt Sebastian
Published: December 2018

When dealing with evolving or multidimensional complex systems, network theory provides us with elegant ways of describing their constituting components, through, respectively, time‐varying and multilayer complex networks. Nevertheless, the analysis of how these components are related is still an open problem. We here propose a general framework for analysing the evolution of a (complex) system, by describing the structure created by the difference between multiple networks by means of the Information Content metric. Differently from other approaches, which focus on assessing the magnitude of the change, the proposed one allows understanding if the observed changes are due to random noise or to structural (targeted) modifications; in other words, it allows describing the nature of the force driving the changes and discriminating between stochastic fluctuations and intentional modifications. We validate the framework by means of sets of synthetic networks, as well as networks representing real technological, social, and biological evolving systems. We further propose a way of reconstructing network correlograms, which allow converting the system’s evolution to the frequency domain.
Rapid Determination of Sotolon in Fortified Wines Using a Miniaturized Liquid-Liquid Extraction Followed by LC-MS/MS Analysis
Authors: Pereira Vanda , Leça João M. , Gaspar João M. , Pereira Ana C. , Marques José C.
Published: December 2018

Sotolon (4,5-dimethyl-3-hydroxy-2,5-dihydrofuran-2-one) is a powerful odorant usually pointed out as being responsible not only for the characteristic curry notes of the finest fortified wines but also for the off-flavour notes in prematurely oxidized white wines. Most methods reported in literature for quantifying sotolon in wines are quite laborious and use large volumes of organic solvents. Thus, in the present study, the development of a simple, fast, and environment-friendly method for the quantification of sotolon in fortified wine is herein presented. The proposed method uses a single-step liquid-liquid extraction followed by RP-LC-MS/MS and was optimized using a full factorial design. The method showed good linearity (R2 = 0.9999), intra- and interday precision lower than 10% RSD, recovery of about 95%, and high sensitivity (LOQ of 0.04 μg/L). The method was applied to analyse 44 fortified wines from different styles (from dry to sweet wines) and ages (3–115 years old), and it was found that it covers the concentration range usually found for this compound in this kind of alcoholic beverages, which was found to be within 6.3–810 μg/L. Thus, it can be concluded that this method can be used as an accurate tool for the rapid analysis of sotolon, since the early stages of its formation up to long ageing periods.
Rheumatoid Meningoencephalitis: A Feared Condition in the Era of TNF Blockers
Authors: Figueroa Rodriguez Fernando , Minkyung Kwon , Jinna Sruthi , Farshad Sohail , Davila Francisco
Published: December 2018

Central nervous system (CNS) involvement in rheumatoid arthritis (RA) is uncommon, and most of the times, it is secondary to vasculitic processes or extra-articular rheumatoid nodules. Meningeal involvement is extremely rare. In the literature, there are a few case reports, series, and retrospective studies which have demonstrated the association of rheumatoid (aseptic) meningoencephalitis after starting tumor necrosis factor (TNF) inhibitors. We present a case of rheumatoid meningoencephalitis (RME) in a 52-year-old male with a history of RA on adalimumab who presented with headaches associated with motor and sensory deficits, all of which resolved after this diagnosis was achieved and received appropriate therapy with high-dose glucocorticoids. We also present an update with high yield points summarizing clinical features, diagnostic workup, and management of RME. Finally, we post a literature review of relevant CNS rheumatoid disease in patients with and without exposure to TNF inhibitors.
Human Activity Recognition and Location Based on Temporal Analysis
Authors: Ding Hongjin , Gong Faming , Gong Wenjuan , Yuan Xiangbing , Ma Yuhui
Published: December 2018

Current methods of human activity recognition face many challenges, such as the need for multiple sensors, poor implementation, unreliable real-time performance, and lack of temporal location. In this research, we developed a method for recognizing and locating human activities based on temporal action recognition. For this work, we used a multilayer convolutional neural network (CNN) to extract features. In addition, we used refined actionness grouping to generate precise region proposals. Then, we classified the candidate regions by employing an activity classifier based on a structured segmented network and a cascade design for end-to-end training. Compared with previous methods of action classification, the proposed method adds the time boundary and effectively improves the detection accuracy. To test this method empirically, we conducted experiments utilizing surveillance video of an offshore oil production plant. Three activities were recognized and located in the untrimmed long video: standing, walking, and falling. The accuracy of the results proved the effectiveness and real-time performance of the proposed method, demonstrating that this approach has great potential for practical application.
Remission from Alcohol Use Disorder among Males in the Lundby Cohort during 1947–1997
Authors: Mattisson Cecilia , Bogren Mats , Horstmann Vibeke , Öjesjö Leif , Brådvik Louise
Published: December 2018

Background. Alcohol use disorders are a major health problem, often with a chronic course. Studies on remission from alcohol use disorders are sparse. Objective. The aim of this study was to analyse the rate of remission from AUD and the possible influence of other mental disorders and sociodemographic factors on the remission in the Lundby Cohort. Method. Remission from AUD was studied for 312 male subjects in the Lundby Cohort, which was followed for 50 years. Cox regression analyses were used to study the possible influence of sociodemographic variables and other mental disorders on AUD remission. Results. In all, 64/312 (21%) subjects achieved remission during the study period. The presence of a severe mental disorder, such as delirium tremens and organic disorders, was related to remission. Blue-collar workers had higher rates of remission than white-collar workers. There was indication that treatment improved the prognosis. Conclusions. The overall remission rate was low, but treatment may improve the prognosis. Severe mental disorders, such as delirium tremens and organic disorders as well as being blue-collar rather than white-collar worker, were related to remission.
Relating Sensory, Cognitive, and Neural Factors to Older Persons’ Perceptions about Happiness: An Exploratory Study
Authors: Horne Alexandra J. , Chiew Kimberly S. , Zhuang Jie , George Linda K. , Adcock R. Alison , Potter Guy G. , Lad Eleonora M. , Cousins Scott W. , Lin Frank R. , Mamo Sara K. , Chen Nan-Kuei , Maciejewski Abigail J. , Duong Fernandez Xuan , Whitson Heather E.
Published: December 2018

Despite increased rates of disease, disability, and social losses with aging, seniors consistently report higher levels of subjective well-being (SWB), a construct closely related to happiness, than younger adults. In this exploratory study, we utilized an available dataset to investigate how aspects of health commonly deteriorating with age, including sensory (i.e., vision and hearing) and cognitive status, relate to variability in self-described contributors to happiness. Community-dwelling seniors (n = 114) responded to a single-item prompt: “name things that make people happy.” 1731 responses were categorized into 13 domains of SWB via structured content analysis. Sensory health and cognition were assessed by Snellen visual acuity, pure-tone audiometry, and in-person administration of the Brief Test of Adult Cognition by Telephone (BTACT) battery. A subset of eligible participants (n = 57) underwent functional magnetic resonance imaging (fMRI) to assess resting state functional connectivity (FC) within a previously described dopaminergic network associated with reward processing. SWB response patterns were relatively stable across gender, sensory status, and cognitive performance with few exceptions. For example, hearing-impaired participants listed fewer determinants of SWB (13.59 vs. 17.16; p<0.001) and were less likely to name things in the “special events” category. Participants with a higher proportion of responses in the “accomplishments” domain (e.g., winning, getting good grades) demonstrated increased FC between the ventral tegmental area and nucleus accumbens, regions implicated in reward and motivated behavior. While the framework for determinants of happiness among seniors was largely stable across the factors assessed here, our findings suggest that subtle changes in this construct may be linked to sensory loss. The possibility that perceptions about determinants of happiness might relate to differences in intrinsic connectivity within reward-related brain networks also warrants further investigation.
CD5-Positive Intravascular Large B-Cell Lymphoma in a Patient with Wilson’s Disease: Case Report and Review of the Literature
Authors: Gupta Neha , Katte Carreon Chrystalle , Sen Filiz , Farmer Peter , Zhang Xinmin , Sheikh-Fayyaz Silvat , Haghi Nina
Published: December 2018

Intravascular large B-cell lymphoma (IVLBCL) is a rare extra-nodal B-cell lymphoma that proliferates within small/intermediate blood vessels and capillaries while sparing large blood vessels and organ parenchyma. Clinical presentation is highly variable and may include B symptoms, neurological deficits, and/or cutaneous findings. The diagnosis of IVLBCL is difficult due to multiorgan involvement and nonspecific symptoms. We describe the case of a 68-year-old male who presented with progressive weakness, confusion, and falls. He had a past medical history of liver cirrhosis secondary to Wilson’s disease. Physical exam and laboratory results revealed a lethargic man with jaundice, hepatic encephalopathy, and abnormal liver/kidney function tests. He expired after a short hospital course in the setting of hepatic and renal failure. Postmortem examination revealed large neoplastic lymphoid cells involving multiple organ blood vessels; however skin and neurologic involvement was absent. The neoplastic cells demonstrated B-cells positive for CD5, rendering a diagnosis of IVLBCL. Our case represents the occurrence of IVLBCL with CD5-positivity in a patient with Wilson’s disease, diagnosed at autopsy demonstrating the challenging nature of diagnosing IVLBCL.
Combined Phacoendoscopic Cyclophotocoagulation versus Combined Phacotrabeculectomy in the Management of Coexisting Cataract and Glaucoma: A Comparative Study
Authors: Lau Charles Sing Lok , Chan Jeffrey Chi Wang , So Sophia Fei , Chan Orlando Chia Chieh , Li Kenneth Kai Wang
Published: December 2018

Purpose. To compare the surgical outcome of combined phacoemulsification and endoscopic cyclophotocoagulation (phacoECP) versus combined phacoemulsification and mitomycin C-augmented trabeculectomy (phacoTbx) in patients with coexisting glaucoma and visually significant cataract. Methods. A retrospective review of 89 eyes of 89 patients who received phacoECP (N=49) and phacoTbx (N=40) was carried out at a tertiary eye center in Hong Kong. The minimum follow-up period was 6 months. Criterion of success was reduction of IOP at least 30% or absolute IOP of 15 mmHg or below without (complete success) or with (qualified success) antiglaucomatous medication. Results. PhacoTbx had more reduction of antiglaucomatous medication (4 vs 1, P<0.001). At postoperative year one, there was more IOP reduction for phacoTbx than phacoECP (8 mmHg vs 3 mmHg, P=0.012). The one-year complete success rate was also higher for phacoTbx (46.2% vs 8.2%, P<0.001), while qualified success was comparable between the 2 groups (74.4% vs 73.5%, P=0.925). Operation time was shorter for phacoECP (37 vs 73 minutes, P<0.001). The number of postoperative follow-up visits was less (6 vs 11.5, P<0.001) for phacoECP. Additional surgical procedures were more common in phacoTbx (55% vs 0%, P<0.001). There was no postoperative cystoid macula edema, hypotony, or endophthalmitis reported in both groups. Conclusions. PhacoECP is significantly less effective than phacoTbx in reduction of both IOP and number of antiglaucomatous medications for patients with medically uncontrolled glaucoma and cataract. Its complete success rate is also significantly lower than that of phacoTbx. With its comparable qualified success, shorter operation time, less number of postoperative visits, and secondary surgical intervention, phacoECP may still have a role in very selected cases.