bluuebunny/crossref_metadata_2025 huggingface dataset:
Serum Levels of Adipolin and Adiponectin and Their Correlation with Perinatal Outcomes in Gestational Diabetes Mellitus
Authors: Muntean Mihai , Săsăran Vladut , Luca Sonia-Teodora , Suciu Laura Mihaela , Nyulas Victoria , Mărginean Claudiu
Published: July 2024

Objectives: This study aimed to investigate the serum level of adipolin and adiponectin in healthy pregnant women and pregnant women with gestational diabetes mellitus (GDM) during the second trimester, the prepartum period, and in the newborns of these patients. Methods: A total of 55 women diagnosed with GDM and 110 healthy pregnant women were included in this study. Pearson’s and Spearman’s correlation coefficients were calculated to determine the association of adipolin and adiponectin with anthropometric markers of obesity (body mass index (BMI), mid-upper arm circumference (MUAC), tricipital skinfold thickness (TST)), inflammation markers (neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), C-reactive protein (CRP)), and maternal glucose homeostasis parameters (fasting glucose, insulin, C peptide, glycosylated hemoglobin A1c (HbA1c), Insulin Resistance—Homeostatic Model Assessment (IR HOMA)). Results: There were no statistical differences between the adipolin value in patients with GDM compared to healthy patients (p = 0.65 at diagnosis and p = 0.50 prepartum) and in newborns from mothers with GDM compared to healthy mothers (p = 0.24). Adipolin levels are significantly higher in patients with GDM who gave birth via cesarean section (p = 0.01). In patients with GDM, the adipolin level correlates positively with HgA1c in the prepartum period. We found a positive correlation between the maternal adipolin values at diagnosis and prepartum and neonatal adipolin (respectively: r = 0.556, p = 0.001; r = 0.332, p = 0.013). Adiponectin levels were significantly lower in patients with GDM at diagnosis and prepartum (p = 0.0009 and p = 0.02), but their levels increased prepartum (5267 ± 2114 ng/mL vs. 6312 ± 3150 ng/mL p = 0.0006). Newborns of mothers with GDM had lower adiponectin levels than newborns of healthy mothers (p < 0.0001). The maternal adiponectin value correlates negatively with maternal BMI, MUAC, and IR HOMA in both groups at diagnosis and prepartum. There were no differences between the groups in terms of cesarean rate (p > 0.99). The relative risk of occurrence of adverse events in patients with GDM compared to healthy ones was 2.15 (95% CI 1.416 to 3.182), and the odds ratio for macrosomia was 4.66 (95% CI 1.591 to 12.69). Conclusions: There was no difference in adipolin levels between mothers with GDM and healthy mothers during the second trimester and the prepartum period. Adipolin is known to enhance insulin sensitivity and reduce inflammation, but unlike adiponectin, it does not appear to contribute to the development of GDM.
Challenges in Providing an Overview of Results of Intermittent Fasting Interventions on Diabetes Parameters. Comment on Silva et al. Effects of Intermittent Fasting on Regulation of Metabolic Homeostasis: A Systematic Review and Meta-Analysis in Health and Metabolic-Related Disorders. J. Clin. Med. 2023, 12, 3699
Authors: Dietvorst Carmen , Kroon Jur , Slebe Romy , Serlie Mireille J. , Berk Kirsten A. , Rutters Femke
Published: July 2024

We hereby comment on the systematic review “Effects of Intermittent Fasting on Regulation of Metabolic Homeostasis: A Systematic Review and Meta-Analysis in Health and Metabolic-Related Disorders” by Silva et al [...]
Development and Validation of Four Different Methods to Improve MRI-CEST Tumor pH Mapping in Presence of Fat
Authors: Gammaraccio Francesco , Villano Daisy , Irrera Pietro , Anemone Annasofia A. , Carella Antonella , Corrado Alessia , Longo Dario Livio
Published: July 2024

CEST-MRI is an emerging imaging technique suitable for various in vivo applications, including the quantification of tumor acidosis. Traditionally, CEST contrast is calculated by asymmetry analysis, but the presence of fat signals leads to wrong contrast quantification and hence to inaccurate pH measurements. In this study, we investigated four post-processing approaches to overcome fat signal influences and enable correct CEST contrast calculations and tumor pH measurements using iopamidol. The proposed methods involve replacing the Z-spectrum region affected by fat peaks by (i) using a linear interpolation of the fat frequencies, (ii) applying water pool Lorentzian fitting, (iii) considering only the positive part of the Z-spectrum, or (iv) calculating a correction factor for the ratiometric value. In vitro and in vivo studies demonstrated the possibility of using these approaches to calculate CEST contrast and then to measure tumor pH, even in the presence of moderate to high fat fraction values. However, only the method based on the water pool Lorentzian fitting produced highly accurate results in terms of pH measurement in tumor-bearing mice with low and high fat contents.
Estimating Nearshore Morphological Change through Ensemble Optimal Interpolation with Altimetric Data
Authors: Geheran Matthew P. , DeVore Katherine R. , Farthing Matthew W. , Bak A. Spicer , Brodie Katherine L. , Hesser Tyler J. , Dickhudt Patrick J.
Published: July 2024

Nearshore bathymetry changes on scales of hours to months in ways that strongly impact coastal processes. However, even at the best-monitored sites, surveys are typically not conducted with sufficient frequency to capture important changes such as sandbar migration. As a result, nearshore models often rely on outdated bathymetric boundary conditions, which may introduce significant errors. In this study, we investigate ensemble optimal interpolation (EnOI) as a method to update survey-derived bathymetry with altimetric measurements that are spatially sparse but have high temporal availability. We present the results of two synthetic examples and two field data experiments that demonstrate the ability of the method to accurately track morphological change between surveys. The method reduces the RMSE relative to a static bathymetry (corresponding to the day before the first assimilation step) by 23% to 68%. When compared with an estimate linearly interpolated between survey-derived bathymetries, the EnOI analysis reduces the RMSE by 19% to 47% in three out of the four experiments.
Numerical Simulation of Gas Production Behavior Using Stepwise Depressurization with a Vertical Well in the Shenhu Sea Area Hydrate Reservoir of the South China Sea
Authors: Wan Tinghui , Li Zhanzhao , Lu Hongfeng , Wen Mingming , Chen Zongheng , Tian Lieyu , Li Qi , Qu Jia , Wang Jingli
Published: July 2024

Stepwise depressurization is an important depressurization strategy in the development of natural gas hydrates. This work numerically analyzes the effects of different depressurization gradients and constant pressure durations on gas and water production during stepwise depressurization extraction with a vertical well in the Shenhu Sea area hydrate reservoir of the South China Sea. The results indicate that stepwise depressurization can reduce water production and raise the gas-to-water ratio in the early stages of production while ensuring cumulative gas output. When the vertical well is deployed at the model’s center with a completion length of 70 m and a constant pressure duration of 10 days, a depressurization gradient of 0.5 MPa, stepwise depressurization by 6 MPa, and continuous production for one year is achieved. Compared with direct depressurization, its cumulative gas production is 2.966 × 106 ST m3, which only decreases by 2.94%. However, it maintains a higher gas-to-water ratio in the early stages of production. Considering factors such as engineering operability, cumulative gas output, and gas-to-water ratio, it is recommended to use a small pressure gradient and a medium constant pressure stabilization time for stepwise depressurization Stepwise depressurization can maintain a high gas-to-water ratio while ensuring gas production and reducing water production can alleviate sand production problems and improve economic efficiency. The understanding gained from this work has reference value for the development of similar hydrate reservoirs worldwide.
An Underwater Multisensor Fusion Simultaneous Localization and Mapping System Based on Image Enhancement
Authors: Liang Zeyang , Wang Kai , Zhang Jiaqi , Zhang Fubin
Published: July 2024

As a key method of ocean exploration, the positioning accuracy of autonomous underwater vehicles (AUVs) directly influences the success of subsequent missions. This study aims to develop a novel method to address the low accuracy in visual simultaneous localization and mapping (SLAM) within underwater environments, enhancing its application in the navigation and localization of AUVs. We propose an underwater multisensor fusion SLAM system based on image enhancement. First, we integrate hybrid attention mechanisms with generative adversarial networks to address the blurring and low contrast in underwater images, thereby increasing the number of feature points. Next, we develop an underwater feature-matching algorithm based on a local matcher to solve the feature tracking problem caused by grayscale changes in the enhanced image. Finally, we tightly couple the Doppler velocity log (DVL) with the SLAM algorithm to better adapt to underwater environments. The experiments demonstrate that, compared to other algorithms, our proposed method achieves reductions in both mean absolute error (MAE) and standard deviation (STD) by up to 68.18% and 44.44%, respectively, when all algorithms are operating normally. Additionally, the MAE and STD of our algorithm are 0.84 m and 0.48 m, respectively, when other algorithms fail to operate properly.
Numerical Investigation of Tsunami Wave Force Acting on Twin Box-Girder Bridges
Authors: Yan Quansheng , Li Xianyun , Jia Buyu , Yu Xiaolin , Luo Yufan
Published: July 2024

Earthquakes in coastal areas frequently trigger tsunami waves, posing significant threats to low-lying coastal bridges. Investigating extreme wave force on bridge deck is crucial for understanding bridge damage mechanisms. However, the majority of current research focuses on single bridge deck, with limited analysis of wave impacts on twin bridge decks. In this paper, solitary wave is utilized to simulate tsunami wave, and a two-dimensional (2D) computational fluid dynamics (CFDs) model to analyze wave–bridge interactions and investigate the impact of tsunami wave on adjacent twin box-girder bridge decks. The numerical model was validated by solitary wave theory and wave force data obtained from the published experiment. Based on this model, the effects of the submergence coefficient, wave height, and deck spacing on the horizontal and vertical forces on the twin box-girder bridge decks were analyzed and compared with those in a single box-girder bridge deck. The results indicate that, firstly, due to wave reflection and the trapped water, the vertical wave force on the twin forward bridge deck significantly surpasses that on the single bridge deck. Furthermore, the twin backward bridge deck experiences greater horizontal force than single deck when the deck is completely submerged. Secondly, the maximum wave force on the twin bridge decks does not always consistently decrease with increasing deck spacing. Finally, the negative horizontal force would exceed the positive horizontal force on the twin forward bridge deck under higher wave. This paper delineates the disparities between twin and single box-girder bridge deck responses to wave action and analyzes the influencing factors. Such insights are pivotal for coastal bridge construction and natural disaster risk assessment.
Temporal Dynamics of Airborne Concentrations of Ganoderma Basidiospores and Their Relationship with Environmental Conditions in Oil Palm (Elaeis guineensis)
Authors: López-Vásquez Juan Manuel , Castillo Sandra Yulieth , Zúñiga León Franky , Sarria Greicy Andrea , Morales-Rodríguez Anuar
Published: July 2024

Basal Stem Rot (BSR), caused by Ganoderma spp., is one of the most important emerging diseases of oil palm in Colombia and is so far restricted to only two producing areas in the country. However, despite the controls established to prevent its spread to new areas, containment has not been possible. This study aimed to understand BSR’s propagation mechanisms and related environmental conditions by measuring Ganoderma basidiospores’ concentrations at various heights using four 7-day Burkard volumetric samplers in a heavily affected plantation. Meteorological data, including solar radiation, temperature, humidity, precipitation, and wind speed, were also recorded. Analysis revealed higher basidiospore concentrations below 4 m, peaking at 02:00 h, with increased levels towards the study’s end. Spore concentrations were not directly influenced by temperature, humidity, or precipitation, but showed higher releases during drier periods. A significant correlation was found between wind speed and spore concentration, particularly below 1.5 m/s, though higher speeds might aid long-distance pathogen spread. This study highlights the complexity of BSR propagation and the need for continued monitoring and research to manage its impact on Colombia’s oil palm industry.
Four New Species of Jelly Fungi from Northeastern China
Authors: Wang Xia , Bau Tolgor
Published: July 2024

Four new species of jelly fungi were described from northeastern China based on morphological and molecular evidence. These new species were classified into the four genera Sirobasidium (Sirobasidium jilinense), Calocera (Calocera velutina), Dacrymyces (Dacrymyces jauensis), and Dacryopinax (Dacryopinax manghanensis). Maximum likelihood and Bayesian analyses were performed using a combined nuc rDNA internal transcribed spacer region (ITS) and nuc 28S rDNA (nrLSU) dataset for the construction of phylogenetic trees. Morphological descriptions, line illustrations, and the ecological habits of these new species are provided.
Reliability, Concurrent Validity, and Clinical Performances of the Shorter Version of the Roland Morris Disability Questionnaire in a Sample of Italian People with Non-Specific Low Back Pain
Authors: Paolucci Teresa , Pezzi Letizia , Coraci Daniele , Tognolo Lucrezia , Pantalone Andrea , Attanasi Carmine , Graziani Giancarlo , Dalla Costa Davide , Arippa Federico , Cichelli Alice , Monticone Marco
Published: July 2024

Background. Evaluating the psychometric and clinical performances of the RM-18, the shorter version of the Roland Morris Disability Questionnaire (RMQ), in Italian people with non-specific low back pain (NSLBP) as a time-saving and clinically useful method of assessing disability. Methods. This cross-sectional study included 74 people (52 females and 22 males, 53.03 ± 15.25 years old) with NSLBP. The RM-18, the RMQ, the Oswestry Disability Index (ODI), and a pain intensity numerical rating scale (NRS) were administered. Psychometric testing included reliability by internal consistency (Cronbach’s alpha) and test–retest measurement (Intraclass Correlation Coefficient, ICC2.1), and concurrent validity by comparing the RM-18 with the RMQ and the ODI (Pearson’s r correlation). Two separate regression analyses were performed to investigate the different impact of RM-18 and RMQ on NRS. Results. Cronbach’s α of RM-18 was 0.92 and ICC (2,1) = 0.96. Strong correlations were found with the RMQ and the ODI (r = 0.98; r = 0.78, respectively). The regression models showed that the RM-18 and the RMQ similarly impacted the NRS (p < 0.001). Conclusion. The RM-18 showed satisfactory psychometric testing and similarly impacted the NRS when compared to the RMQ. It can be recommended for clinical and research purposes in Italian people with NSLBP.
Fluid Restriction for Patients with Heart Failure: Current Evidence and Future Perspectives
Authors: Kato Naoko P. , Nagatomo Yuji , Kawai Fujimi , Kitai Takeshi , Mizuno Atsushi
Published: July 2024

Fluid restriction has long been believed to benefit patients with heart failure by counteracting the activated renin–angiotensin aldosterone system and sympathetic nervous activity. However, its effectiveness remains controversial. In this paper, we summarized the current recommendations and reviewed the scientific evidence on fluid restriction in the setting of both acute decompensated heart failure and compensated heart failure. While a recent meta-analysis demonstrated the beneficial effects of fluid restriction on both all-cause mortality and hospitalization compared to usual care, several weaknesses were identified in the assessment of the methodological quality of the meta-analysis using AMSTAR 2. Further randomized controlled trials with larger sample sizes are needed to elucidate the benefits of fluid restriction for both clinical outcomes and patient-reported outcomes in patients with heart failure.
Natural Language Processing and Schizophrenia: A Scoping Review of Uses and Challenges
Authors: Deneault Antoine , Dumais Alexandre , Désilets Marie , Hudon Alexandre
Published: July 2024

(1) Background: Approximately 1% of the global population is affected by schizophrenia, a disorder marked by cognitive deficits, delusions, hallucinations, and language issues. It is associated with genetic, neurological, and environmental factors, and linked to dopaminergic hyperactivity and neurotransmitter imbalances. Recent research reveals that patients exhibit significant language impairments, such as reduced verbal output and fluency. Advances in machine learning and natural language processing show potential for early diagnosis and personalized treatments, but additional research is required for the practical application and interpretation of such technology. The objective of this study is to explore the applications of natural language processing in patients diagnosed with schizophrenia. (2) Methods: A scoping review was conducted across multiple electronic databases, including Medline, PubMed, Embase, and PsycInfo. The search strategy utilized a combination of text words and subject headings, focusing on schizophrenia and natural language processing. Systematically extracted information included authors, population, primary uses of the natural language processing algorithms, main outcomes, and limitations. The quality of the identified studies was assessed. (3) Results: A total of 516 eligible articles were identified, from which 478 studies were excluded based on the first analysis of titles and abstracts. Of the remaining 38 studies, 18 were selected as part of this scoping review. The following six main uses of natural language processing were identified: diagnostic and predictive modeling, followed by specific linguistic phenomena, speech and communication analysis, social media and online content analysis, clinical and cognitive assessment, and linguistic feature analysis. (4) Conclusions: This review highlights the main uses of natural language processing in the field of schizophrenia and the need for more studies to validate the effectiveness of natural language processing in diagnosing and treating schizophrenia.
Rio de Janeiro Botanical Garden: Biodiversity Conservation in a Tropical Arboretum
Authors: Almeida Thaís Moreira Hidalgo de , Coelho Marcus Alberto Nadruz , Peixoto Ariane Luna
Published: July 2024

In light of increasing human impacts on natural areas and climate change, urgent action is required to accelerate species conservation efforts. Ex situ conservation has gained importance, yet the increasing endangered species challenge is magnified in botanic gardens, notably tropical ones, insufficient to safeguard such diverse flora. This study focused on the living collection of the arboretum at the Rio de Janeiro Botanical Garden, examining all cultivated specimens and institutional database records between January and July 2023. It cross-referenced the collection’s composition with the Flora e Funga do Brasil list, as well as Red Lists, to reveal that the collection includes 6960 specimens representing 1420 species, with 60.6% of these species native to Brazil, belonging to 134 botanical families. The collection encompasses all Brazilian phytogeographic domains, with the Atlantic Forest and the Amazon having the highest number of species in cultivation. In terms of conservation efforts, the collection includes 83 species from the Brazilian Red List and 106 species from the IUCN Red List, contributing to the Global Strategy for Plant Conservation, Target 8. This evaluation is the first step toward identifying collection gaps, future planning, and targeting species for acquisition to enhance the effectiveness of our conservation efforts.
In Memory of George Bakris (1952–2024)
Authors: Locatelli Francesco , Piccoli Giorgina B. , Roth Peter
Published: July 2024

Prof. Dr. George Bakris was an Editorial Board Member of Kidney and Dialysis. His invaluable contributions were instrumental in guiding the journal’s direction and enhancing its success. We are deeply grateful for his unwavering dedication, commitment, and active involvement in the journal’s development.
Cell Therapy in the Treatment of Female Stress Urinary Incontinence: Current Status and Future Proposals
Authors: González Enguita Carmen , Garranzo García-Ibarrola María , Tufet I Jaumont Jaime Jorge , Garde García Héctor , González López Raquel , Quintana Franco Luis Miguel , Torres Zambrano Gina Marcela , García-Arranz Mariano
Published: July 2024

Background: Stress urinary incontinence (SUI) is a common condition with a significant impact on the quality of life of female patients. The limitations of current treatment strategies have prompted the exploration of new effective and minimally invasive alternative approaches, including cell therapy. Methods: A literature search was conducted to update the current clinical status of stem cell therapy in the management of female stress urinary incontinence. Results: Over thirty clinical studies have been designed to assess the feasibility, safety and efficacy of cell therapy for female SUI. Despite differences in cell types and protocols, the overall treatment procedures were similar. Standard subjective and objective assessment tools, and follow-up periods ranged from 6 weeks to 6 years have been used. Cell injection has shown to be a safe therapy in the treatment of female SUI. However, the results from more recent randomized trials have shown less promising results than expected in restoring continence. Heterogeneous research methodologies using different cell types and doses make it difficult to draw conclusions about effectiveness. Several key points remain that need to be further explored in future clinical trials. Conclusion: To advance in the development of cell therapy, it is essential to know the mechanisms involved to be able to direct it properly, its efficacy and the durability of the injected cells. Rigorous and homogenized preclinical and clinical studies that demonstrate its scope and improve its application are necessary for validation in the treatment of female SUI.
Composition of Proteins Associated with Red Clover (Trifolium pratense) and the Microbiota Identified in Honey
Authors: Čeksterytė Violeta , Kaupinis Algirdas , Aleliūnas Andrius , Navakauskienė Rūta , Jaškūnė Kristina
Published: July 2024

The nutritional composition of honey is determined by environmental conditions, and botanical and geographical origin. In addition to carbohydrates, honey also contain pollen grains, proteins, free amino acids, and minerals. Although the content of proteins in honey is low, they are an important component that confirms the authenticity and quality of honey; therefore, they became a popular study object. The aim of the study was to evaluate protein content and composition of monofloral red clover and rapeseed honey collected from five different districts of Lithuania. Forty-eight proteins were identified in five different origin honey samples by liquid chromatography. The number of red clover proteins identified in individual honey samples in monofloral red clover honey C3 was 39 in polyfloral honey S22–36, while in monofloral rapeseed honey S5, S15, and S23 there was 33, 32, and 40 respectively. Aphids’ proteins and lactic acid bacteria were identified in all honey samples tested. The linear relationship and the strongest correlation coefficient (r = 0.97) were determined between the content of Apilactobacillus kunkeei and Apilactobacillus apinorum, as well as between the number of faba bean (Vicia faba) pollen and lactic acid bacteria (r = 0.943). The data show a strong correlation coefficient between the amount of lactic acid and aphid protein number (r = 0.693). More studies are needed to evaluate the relationship between the pollination efficiency of red clover by bees and the multiplicity of red clover proteins in honey protein, as well as microbiota diversity and the influence of nature or plant diversity on the occurrence of microbiota in honey.
Relevance of the TAS’/PASP Ratio as a Predictor of Outcomes in Patients with Heart Failure with a Reduced Ejection Fraction
Authors: Srdanović Ilija , Stefanović Maja , Milovančev Aleksandra , Vulin Aleksandra , Pantić Teodora , Dabović Dragana , Tadić Snežana , Ilić Aleksandra , Stojšić Milosavljević Anastazija , Bjelobrk Marija , Miljković Tatjana , Velicki Lazar
Published: July 2024

Background: There is evidence that right ventricular (RV) contractile function, especially its coupling with the pulmonary circulation, has an important prognostic value in patients with left ventricular dysfunction. Aims: This study aimed to identify the best echocardiographic parameters of RV function and pulmonary artery systolic pressure (PASP) alone or in the form of the index of right ventricular-pulmonary artery coupling (RV-PA coupling) to determine the best predictor of 1-year major adverse cardiovascular events (MACE), which were defined as cardiovascular death and cardiac decompensation in heart failure patients with reduced ejection fraction (HFrEF). Methods and results: The study enrolled 191 HFrEF patients (mean age 62.28 ± 12.79 years, 74% males, mean left ventricular ejection fraction (LVEF) 25.53 ± 6.87%). All patients underwent clinical, laboratory, and transthoracic echocardiographic (TTE) evaluation, focusing on assessing RV function and non-invasive parameters of RV-PA coupling. RV function was evaluated using fractional area change (FAC), tricuspid annular plane systolic excursion (TAPSE), and peak tricuspid annular systolic velocity (TAS’). PASP was estimated by peak tricuspid regurgitation velocity (TRVmax) and corrected by assumed right atrial pressure relative to the dimension and collapsibility of the inferior vena cava. The TAPSE/PASP and TAS’/PASP ratios were taken as an index of RV-PA coupling. During the follow-up (mean period of 340 ± 84 days), 58.1% of patients met the composite endpoint. The independent predictors of one-year outcome were shown to be advanced age, atrial fibrillation, indexed left atrial systolic volume (LAVI), LVEF, TAPSE/PASP, and TAS’/PASP. TAS’/PASP emerged as the strongest independent predictor of prognosis, with a hazard ratio (HR) of 0.67 (0.531–0.840), p < 0.001. Reconstructing the ROC curve 0.8 (0.723–0.859), p < 0.001, we obtained a threshold value of TAS’/PASP ≤ 0.19 (cm/s/mm Hg) (sensitivity 74.0, specificity 75.2). Patients with TAS’/RVSP ≤ 0.19 have a worse prognosis (Log Rank p < 0.001). Conclusions: This study confirmed previously known independent predictors of adverse outcomes in patients with HfrEF—advanced age, atrial fibrillation, LAVI, and LVEF—but non-invasive parameters of RV-PA coupling TAPSE/PASP and TAS’/PASP improved risk stratification in patients with HFrEF. Variable TAS’/PASP has been shown to be the most powerful, independent predictor of one-year outcome.
Motor and Respiratory Tele-Rehabilitation in Patients with Long COVID-19 after Hospital Discharge: An Interventional Study
Authors: Cerfoglio Serena , Verme Federica , Capodaglio Paolo , Rossi Paolo , Cvetkova Viktoria , Boldini Gabriele , Galli Manuela , Cimolin Veronica
Published: July 2024

The persistence of symptoms following COVID-19 infection represents a significant challenge in healthcare management. During the outbreak, tele-rehabilitation emerged as a new tool to support healthcare structures in providing rehabilitation services. This study assessed the effectiveness and the feasibility of a 3-week home-based motor and respiratory rehabilitation program for individuals with long COVID-19 after traditional rehabilitation. Twenty-three patients completed the program and underwent functional tests at different time points (i.e., baseline, at discharge from in-hospital rehabilitation and after tele-rehabilitation). Motor function was evaluated using the instrumented Six-Minutes Walking Test (i6MWT), with monitored heart rate and oxygen saturation. Additionally, respiratory function was measured via forced vital capacity (FVC) and maximal voluntary ventilation (MVV) tests. Significant improvements (p < 0.05) in motor and respiratory function were observed throughout the intervention, including an 18.3% increase in walked distance from the baseline. The findings suggest that the proposed home-based tele-rehabilitation shows potential in enhancing motor and respiratory function in patients with long COVID. Despite limitations such as the small sample size, lack of control group and the preliminary nature of the outcomes observed, the overall findings seem to support the feasibility of the proposed tele-rehabilitation program in managing long COVID symptoms and promoting functional recovery. Nevertheless, further research is needed to validate these findings and explore tele-rehabilitation’s potential in broader and different patient populations
Cancer-Associated Thrombotic Microangiopathy: Literature Review and Report of Five Cases
Authors: Posado-Domínguez L. , Chamorro A.-J. , Del Barco-Morillo E. , Martín-Galache M. , Bueno-Sacristán D. , Fonseca-Sánchez E. , Olivares-Hernández A.
Published: July 2024

Thrombotic microangiopathy (TMA) is an anatomopathological lesion mediated by endothelial dysfunction and characterized by the creation of microthrombi in small vessels. In patients with cancer, it may be due to toxicity secondary to chemotherapy, tumor embolization, or hematopoietic progenitor transplantation. Cancer-associated TMA is an underestimated entity that generally appears in the final stages of the disease, although it may also be the initial manifestation of an underlying cancer. Support treatment is necessary in all cases and, depending on the cause, different targeted therapies may be used. The prognosis is very poor. In this article we present a comprehensive review of the existing literature on the physiological mechanisms of cancer-associated TMA. Afterwards, five clinical cases will be presented of patients who developed TMA and were diagnosed in our Department in 2023. We present a discussion of the different causes that triggered the condition, the possible reasons behind the underestimation of this pathology, and the measures that may be adopted.
The Contemporary Role of Salvage Radical Prostatectomy in the Management of Recurrent Prostate Cancer: An Up-to-Date Review
Authors: Katsimperis Stamatios , Pinitas Alexandros , Zerva Maria , Bellos Themistoklis , Manolitsis Ioannis , Feretzakis Georgios , Verykios Vassilios S. , Kyriazis Ioannis , Neofytou Panagiotis , Kapsalos Sotirios , Deligiannis Panagiotis , Triantafyllou Panagiotis , Juliebø-Jones Patrick , Somani Bhaskar , Mitsogiannis Iraklis , Tzelves Lazaros
Published: July 2024

Prostate cancer is the second most common cancer among men, with many treatment modalities available for patients, such as radical prostatectomy, external beam radiotherapy, brachytherapy, high-intensity focused ultrasound, cryotherapy, electroporation and other whole-gland or focal ablative novel techniques. Unfortunately, up to 60% of men with prostate cancer experience recurrence at 5 to 10 years. Salvage radical prostatectomy can be offered as an option in the setting of recurrence after a primary non-surgical treatment. However, the complexity of salvage radical prostatectomy is considered to be greater than that of primary surgery, making it the least popular treatment of choice. With the wide use of robotic platforms in urologic oncologic surgery, salvage radical prostatectomy has attracted attention again because, compared to past data, modern series involving salvage Robot-Assisted Radical Prostatectomy have shown promising results. In this narrative literature review, we comprehensively examined data on salvage radical prostatectomy. We investigated the correlation between the different types of primary prostate cancer therapy and the following salvage radical prostatectomy. Furthermore, we explored the concept of a robotic approach and its beneficial effect in salvage surgery. Lastly, we emphasized several promising avenues for future research in this field.
Liver and Inflammatory Biomarkers Are Related to High Mortality in Hospitalized Patients with COVID-19 in Brazilian Amazon Region
Authors: Silva Carla Sousa da , Martinelli Katrini Guidolini , Viana Marlison Wesley Miranda , Soares Deliane dos Santos , Corrêa Yasmin Garcia Silva , Silva Lucas Lima da , Paula Vanessa Salete de , Rodrigues Luana Lorena Silva , Villar Livia Melo
Published: July 2024

COVID-19 is a multisystem disease with many clinical manifestations, including liver damage and inflammation. The objective of this study is to analyze inflammation biomarkers in relation to the clinical outcome and respiratory symptoms of COVID-19. This is a retrospective cohort of patients with COVID-19 admitted to the Hospital Regional do Baixo Amazonas from 2020 to 2022. Data were collected from electronic medical records from admission to the 30th day of hospitalization and soon after hospital discharge. A total of 397 patients were included in the study. In the longitudinal follow-up of liver markers, a significant difference was found for AST on day 14, with a higher median in the death group. Among the hematological markers, lymphopenia was observed throughout the follow-up, with the death group having the most altered values. When comparing the evolution of biomarkers in the Non-Invasive Ventilation (NIV) and Invasive Mechanical Ventilation (IMV) groups, AST showed a significant difference only on day 14 and GGT on day 1, being greater in the IMV group, and indirect bilirubin on day 7 being more altered in the NIV group. In conclusion, death during hospitalization or a more severe form of COVID-19 was related to significant changes in liver and inflammatory biomarkers.
Image-Guided Stereotactic Body Radiotherapy on Detectable Prostate Bed Recurrence after Prostatectomy in RT-Naïve Patients
Authors: Santamaria Riccardo , Zaffaroni Mattia , Vincini Maria Giulia , Colombi Lorenzo , Gaeta Aurora , Mastroleo Federico , Corrao Giulia , Zerini Dario , Villa Riccardo , Mazzola Giovanni Carlo , Alessi Sarah , Luzzago Stefano , Mistretta Francesco Alessandro , Musi Gennaro , De Cobelli Ottavio , Gandini Sara , Kuncman Lukasz , Cattani Federica , Ceci Francesco , Petralia Giuseppe , Marvaso Giulia , Jereczek-Fossa Barbara Alicja
Published: July 2024

Purpose or Objective—The aim of the study is to evaluate the efficacy and safety of SBRT on detectable prostate bed recurrence in RT-naïve prostate cancer patients. Materials and methods: Eighty-six patients who underwent SBRT for macroscopic bed recurrence after prostatectomy were retrospectively included. Patients were treated based on mpMRI or choline/PSMA PET. Results: The median time to biochemical relapse (BCR) after RP was 46 months, with a median PSA at restaging of 1.04 ng/mL. Forty-six patients were staged with mpMRI and choline/PSMA PET, while ten and thirty were treated based on PET and MRI only, respectively. Only one late G ≥ 2 GI toxicity was observed. With a median BCR follow-up of 14 months, twenty-nine patients experienced a BCR with a median PSA at recurrence of 1.66 ng/mL and a median survival free from the event of 40.1 months. The median time to BCR was 17.9 months. Twenty-seven patients had clinical relapse (CR), with a median CR follow-up of 16.27 months and a median time to CR of 23.0 months. Biochemical recurrence-free survival at one and two years was 88% and 66%, respectively, while clinical recurrence-free survival at one and two years was 92% and 82%, respectively. Regarding local relapses, seven were in the field of treatment, while eight of them were outside the field of treatment. Conclusions: Data showed that SBRT targeting only the macroscopic bed recurrence instead of the whole prostate bed is safe and effective. Additional data and longer follow-ups will provide a clearer indication of the appropriate treatment and staging methodology for these patients.
A More Targeted and Selective Use of Implantable Loop Recorders Improves the Effectiveness of Syncope Units: A Single-Center Experience
Authors: Archontakis Stefanos , Oikonomou Evangelos , Sideris Konstantinos , Dourvas Panagiotis , Milaras Nikias , Kostakis Panagiotis , Klogkeri Tzonatan , Triantafyllou Epameinondas , Theofilis Panagiotis , Ntalakouras Ioannis , Arsenos Petros , Gkika Athanasia , Gatzoulis Konstantinos , Sideris Skevos , Tousoulis Dimitris
Published: July 2024

Purpose: Syncope remains a common medical problem. Recently, the role of dedicated syncope units and implantable loop recorders has emerged in the investigation of unexplained syncope. This study aims to investigate the possibilities for a more rational and targeted use of various diagnostic tools. Methods: In this retrospective single-center study, 196 patients with unexplained syncope were included between March 2019 and February 2023. Various diagnostic tools were utilized during the investigation, according to clinical judgement. Patients were retrospectively allocated into Group A (including those who, among other tests, underwent loop recorder insertion) and Group B (including patients investigated without loop recorder implantation). Data were compared with Group C, including patients assessed prior to syncope unit establishment. Results: There was no difference between Group A (n = 133) and Group B (n = 63) in the diagnostic yield (74% vs. 76%, p = 0.22). There were significant differences between Groups A and B regarding age (67.3 ± 16.9 years vs. 48.3 ± 19.1 years, p < 0.001) and cause of syncope (cardiogenic in 69% of Group A, reflex syncope in 77% of Group B, p < 0.001). Electrocardiography-based diagnosis occurred in 55% and 19% of Groups A and B, respectively (p < 0.001). The time to diagnosis was 4.2 ± 2.7 months in Group A and 7.5 ± 5.6 months in Group B (p < 0.001). In Group C, the diagnostic yield was 57.9% and the electrocardiography-based diagnostic yield was 18.3%. Conclusions: A selective use of loop recorders according to clinical and electrocardiographic characteristics increases the effectiveness of the structured syncope unit approach and further preserves financial resources.
The Combination of Laparoscopic and Robotic Surgery: First Experience with the Dexter Robotic System™ in Visceral Surgery
Authors: Conrad Pernilla Virginia , Mehdorn Anne-Sophie , Alkatout Ibrahim , Becker Thomas , Beckmann Jan Henrik , Pochhammer Julius
Published: July 2024

Introduction: For over two decades, abdominal surgical procedures have been safely performed robotically. After the first patent expiration, alternative robotic systems entered the market. The Dexter Robotic System™ is a small-format, modular, and robotic platform consisting of a surgeon’s console, two patient carts with instrument arms, and one endoscope arm. We report our initial experiences with Dexter since its installation at our visceral surgery department. Methods: The system and surgical setup are described. Demographic and perioperative data of all operated patients as well as the system docking times were analyzed. Results: From 56 procedures performed with Dexter, the most common ones included cholecystectomy (n = 15), inguinal hernia repair (TAPP; unilateral n = 15; bilateral n = 3), and right oncologic hemicolectomy (n = 15). The median docking time was 6 min (2–16 min) and was reduced to 4 min in the last tertile of procedures performed. Conclusions: In our experience, Dexter can be implemented without any major challenges, and visceral surgical procedures of simple to medium complexity can be performed safely. The simplicity and accessibility of the system along with the ease of switching between robotics and laparoscopy could be particularly suitable for beginners in robotic surgery
Does Environmental Performance Make Any Difference in the Relationship between Green Supply Chain Management and Hotel Competitiveness?
Authors: Aljoghaiman Abdulaziz , Hasanein Ahmed M. , Elshaer Ibrahim A. , Sobaih Abu Elnasr E.
Published: July 2024

Background: This research examines the direct influence of green supply chain management (GSCM) on hotel competitiveness and the indirect impact through environmental performance (EP). The competition between enterprises in today’s changing marketplace has significantly heightened. Therefore, identifying the factors that contribute to an enterprises’ competitiveness has become more essential than it was previously. Methods: We adopted a pre-tested scale drawn from previous related studies and we were able to collect 430 forms from managers and department heads in Saudi Arabian hotels. Results: The study findings of the structural model by PLS-SEM revealed that environmental and economic GSCM had a considerable beneficial influence on hotel competitiveness. However, the social aspect of GSCM failed to have an extensive effect on hotel competitiveness. All three dimensions of GSCM have a substantial indirect influence on hotel competitiveness via EP. Conclusion: The study developed a complete model that integrates the elements of GSCM with EP and hotel competitiveness. The study presents numerous implications for hoteliers and academics.
Experiments of Main Parameters Affecting the Erosive Behavior of Self-Excited Oscillating Abrasive Water Jets: Length of Self-Oscillation Chamber, Jet Pressure, Abrasive Fluid Velocity, and Abrasive Grain Size
Authors: Tao Baochun , Zhang Chengqi , Deng Qianfa , Wang Qiming , Zhang Hong , Sun Lizhi
Published: July 2024

To enhance the erosion efficiency in traditional abrasive water jet processing, an abrasive water jet processing method based on self-excited fluid oscillation is proposed. Traditional abrasive water jet methods suffer from reduced jet kinetic energy due to the presence of a stagnation layer, which hinders efficient material removal. By integrating a self-oscillation chamber into the conventional abrasive water jet nozzle, the continuous jet is transformed into a pulsed jet, thereby increasing the jet velocity and enhancing the kinetic energy of the process. This modification aims to improve material removal efficiency. Using Ansys Fluent, we simulated the material removal efficiency on workpiece surfaces with varying lengths of self-oscillation chambers. The simulation results reveal that the optimal length of the self-oscillation chamber for maximum erosion is 4 mm. SiC materials were used to evaluate the impact of self-oscillation chamber length (L), jet pressure (P), abrasive flow rate (M), and abrasive grain size (D) on erosion. Experimental results show that the self-oscillation chamber increases erosion depth by 33 μm. The maximum erosion depths recorded were 167 μm when L = 4 mm, 223 μm when P = 16 MPa, 193 μm when M = 80 g/min, and 268 μm when D = 2000 μm. Overall, the self-excited oscillation effect enhances the erosion efficiency of the waterjet by 14%. This study further elucidates the factors influencing erosion behaviors in oscillating abrasive water jet processing.
Ultrathin Carbon Textures Produced on Machined Surfaces in an Integrated Finishing Process Using Microabrasive Films
Authors: Tandecka Katarzyna , Kacalak Wojciech , Wieczorowski Michał , Rokosz Krzysztof , Chapon Patrick , Mathia Thomas G.
Published: July 2024

This study presents research into the unique method of depositing carbon layers onto processed surfaces, during finishing with abrasive films, on a global basis. The authors of this article are holders of the patent for this method. What makes this technology outstanding is that it integrates processes, whereby micro-finishing and the deposition of a carbon layer onto freshly exposed surface fragments is achieved simultaneously, in a single process. Among the main advantages accruable from this process is the reduction of surface irregularities, while the deposition of a carbon layer is achieved simultaneously. Ultrathin graphite layers can be widely used in conditions where other methods of reducing the coefficient of friction are not possible, such as in regard to micromechanisms. This article illustrates the application of carbon coating, end on, on a surface processed with abrasive film, containing intergranular spaces, saturated with graphite. Thin carbon layers were obtained on two substrates that did not contain carbon in their initial composition: soda–lime glass and a tin–bronze alloy. It was performed through microscopic examinations of the produced surface, roughness analyses of these surfaces, and analysis of the chemical compositions determined by two methods, namely EDS and GDOES, proving the existence of the coatings. The aim of this paper is to prove the possibility and efficiency of using graphite-impregnated lapping films in the deposition process of carbon films, with improved surface smoothness, durability, and wear resistance. The produced coatings will be tested in regard to their operational properties in further research. The authors underline the potential of this method to revolutionize surface treatment processes, due to the significant advantages it offers across various industries.
The Advancement of Waterjet-Guided Laser Cutting System for Enhanced Surface Quality in AISI 1020 Steel Sheets
Authors: Paksoy Muhammed , Çandar Hakan , Yılmaz Necip Fazıl
Published: July 2024

This study investigates the effects of a water-guided laser on the cutting performance of AISI 1020 steel sheets of various thicknesses by comparing the results with respect to a conventional laser. For this purpose, a novel nozzle design has been devised enabling the delivery of laser beams to the workpiece conventionally as well as through water guidance. Diverging from prior literature, a fiber laser is used with a high wavelength and a laser power output of 1 kW. Experiments are conducted on steel sheets with thicknesses ranging from 1.5 mm to 3 mm using three different cutting speeds and laser power levels. Analysis focuses on assessing surface roughness, burr formation and heat effects on the cut surfaces for both conventional and waterjet-guided cutting. Surface roughness is evaluated by using a 3D profilometer and cut surfaces are examined through SEM imaging. The results showed that the waterjet-guided laser system greatly reduced surface roughness and minimized problems associated with traditional laser cutting such as kerf, dross adherence and thermal damage. The study revealed that cutting speed had a greater effect on surface roughness reduction than laser power, with the most noticeable differences occurring in thinner sheets. Furthermore, the investigation suggests that the waterjet-guided laser cutting system demonstrates superior performance relative to conventional methods, particularly in surface quality.