bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Table 5 from Hepatocyte Growth Factor Activator Inhibitor Type 1 Is a Suppressor of Intestinal Tumorigenesis
Authors: Hoshiko Shinri , Kawaguchi Makiko , Fukushima Tsuyoshi , Haruyama Yukihiro , Yorita Kenji , Tanaka Hiroyuki , Seiki Motoharu , Inatsu Haruhiko , Kitamura Kazuo , Kataoka Hiroaki
Published: March 2023

PDF file - 33K, Spint1 deletion-induced up- and down-regulated genes involved in cellular responses to DNA damage/repair in non-neoplastic small intestine of Apc-min mice.
Supplementary Table 1 from Autoantibody Signatures Involving Glycolysis and Splicesome Proteins Precede a Diagnosis of Breast Cancer among Postmenopausal Women
Authors: Ladd Jon J. , Chao Timothy , Johnson Melissa M. , Qiu Ji , Chin Alice , Israel Rebecca , Pitteri Sharon J. , Mao Jianning , Wu Mei , Amon Lynn M. , McIntosh Martin , Li Christopher , Prentice Ross , Disis Nora , Hanash Samir
Published: March 2023

PDF file - 54K, Coefficients from linear regression models used for ROC analysis.
Supplementary Methods and Materials, Figure Legends, and References from Clonal Progression of Prostate Cancers from Gleason Grade 3 to Grade 4
Authors: Sowalsky Adam G. , Ye Huihui , Bubley Glenn J. , Balk Steven P.
Published: March 2023

PDF file-124KB, The Supplementary Methods and Materials section contains the procedures for DNA/RNA extraction, Real-Time PCR, Library Preparation and Deep Sequencing, Data Alignment, Breakpoint Sequencing, and Determining PTEN Status.
Supplementary Figures 1-3 and Tables 1-5 from Clonal Progression of Prostate Cancers from Gleason Grade 3 to Grade 4
Authors: Sowalsky Adam G. , Ye Huihui , Bubley Glenn J. , Balk Steven P.
Published: March 2023

PDF file-801KB, Supplementary Figure 1: H&E, PIN-4, and ERG stains on consecutive sections of cancer tissue from Patient 1, 3, and 4 that were used for laser capture microdissection and breakpoint mapping. Supplementary Figure 2: Breakpoint sequence confirmation using Sanger sequencing. Supplementary Figure 3: H&E, PIN-4, and ERG stains on representative sections of tissue showing the presence of ERG-positive and ERG-negative PIN lesions adjacent to ERG-positive cancer tissue. Supplementary Table 1: Summary of TMPRSS2:ERG expression and clinicopathologic characteristics of 52 cases with adjacent G3 and G4 tumor foci stained with anti-ERG. Supplementary Table 2: Percentage of TMPRSS2:ERG Illumina reads for each sample. Supplementary Table 3: The location of the TMPRSS2 and ERG breakpoints for each patient, the mechanism of ERG fusion inferred by SNP genotyping of the interstitial region (either a deletion or balanced translocation) and the type of double-stranded break and end joining indicated by each fusion. Supplmenetary Table 4: Percentage of PTEN Illumina reads for each sample. Supplementary Table 5: SNPs present in the PTEN locus for Patient 3 in G3 (left) and G4 (right) DNA, as determined by Illumina sequencing.
Supplementary Figure 5 from BCR-ABL–Induced Deregulation of the IL-33/ST2 Pathway in CD34(+) Progenitors from Chronic Myeloid Leukemia Patients
Authors: Levescot Anaïs , Flamant Stéphane , Basbous Sara , Jacomet Florence , Féraud Olivier , Anne Bourgeois Elvire , Bonnet Marie-Laure , Giraud Christine , Roy Lydia , Barra Anne , Chomel Jean-Claude , Turhan Ali , Guilhot François , Girard Jean-Philippe , Gombert Jean-Marc , Herbelin André
Published: March 2023

PDF file - 154KB, CML-CP CD34(+) cells proliferate in response to IL-33 independently from GM-CSF.
Supplementary Figure 4 from BCR-ABL–Induced Deregulation of the IL-33/ST2 Pathway in CD34(+) Progenitors from Chronic Myeloid Leukemia Patients
Authors: Levescot Anaïs , Flamant Stéphane , Basbous Sara , Jacomet Florence , Féraud Olivier , Anne Bourgeois Elvire , Bonnet Marie-Laure , Giraud Christine , Roy Lydia , Barra Anne , Chomel Jean-Claude , Turhan Ali , Guilhot François , Girard Jean-Philippe , Gombert Jean-Marc , Herbelin André
Published: March 2023

PDF file - 145KB, IL-33 is as efficient as SCF in inducing proliferation of CML-CP CD34(+) cells.
Supplementary Figure 3 from BCR-ABL–Induced Deregulation of the IL-33/ST2 Pathway in CD34(+) Progenitors from Chronic Myeloid Leukemia Patients
Authors: Levescot Anaïs , Flamant Stéphane , Basbous Sara , Jacomet Florence , Féraud Olivier , Anne Bourgeois Elvire , Bonnet Marie-Laure , Giraud Christine , Roy Lydia , Barra Anne , Chomel Jean-Claude , Turhan Ali , Guilhot François , Girard Jean-Philippe , Gombert Jean-Marc , Herbelin André
Published: March 2023

PDF file - 118KB, IL-33 does not modulate apoptosis of CD34(+) cells from CML-CP patients.
Supplementary Figure Legend from Animal Models of Human Prostate Cancer: The Consensus Report of the New York Meeting of the Mouse Models of Human Cancers Consortium Prostate Pathology Committee
Authors: Ittmann Michael , Huang Jiaoti , Radaelli Enrico , Martin Philip , Signoretti Sabina , Sullivan Ruth , Simons Brian W. , Ward Jerrold M. , Robinson Brian D. , Chu Gerald C. , Loda Massimo , Thomas George , Borowsky Alexander , Cardiff Robert D.
Published: March 2023

PDF file - 60K
Supplementary Table 1 from Contrasting Hypoxic Effects on Breast Cancer Stem Cell Hierarchy Is Dependent on ER-α Status
Authors: Harrison Hannah , Rogerson Lynsey , Gregson Hannah J. , Brennan Keith R. , Clarke Robert B. , Landberg Göran
Published: March 2023

PDF file - 45K, Genes included in RT-PCR Array
Supplementary Figure 2 from Animal Models of Human Prostate Cancer: The Consensus Report of the New York Meeting of the Mouse Models of Human Cancers Consortium Prostate Pathology Committee
Authors: Ittmann Michael , Huang Jiaoti , Radaelli Enrico , Martin Philip , Signoretti Sabina , Sullivan Ruth , Simons Brian W. , Ward Jerrold M. , Robinson Brian D. , Chu Gerald C. , Loda Massimo , Thomas George , Borowsky Alexander , Cardiff Robert D.
Published: March 2023

PDF file - 2674K, Supplementary Figure 2. Lung metastasis versus tumor embolism.
Supplementary Information from scFv-Based “Grababody” as a General Strategy to Improve Recruitment of Immune Effector Cells to Antibody-Targeted Tumors
Authors: Cai Zheng , Fu Ting , Nagai Yasuhiro , Lam Lian , Yee Marla , Zhu Zhiqiang , Zhang Hongtao
Published: March 2023

Supplementary Information PDF file - 77K, Additional information on the HER2 Domain 4 sequence, methods and figure legends for supplemental figures
Supplementary Figure S3 from scFv-Based “Grababody” as a General Strategy to Improve Recruitment of Immune Effector Cells to Antibody-Targeted Tumors
Authors: Cai Zheng , Fu Ting , Nagai Yasuhiro , Lam Lian , Yee Marla , Zhu Zhiqiang , Zhang Hongtao
Published: March 2023

Supplementary Figure S3 PDF file 1739K, Binding of antibodies to D4(508-577) by SPR analysis
Supplementary Figure 7 from Convergence of the ZMIZ1 and NOTCH1 Pathways at C-MYC in Acute T Lymphoblastic Leukemias
Authors: Rakowski Lesley A. , Garagiola Derek D. , Li Choi M. , Decker Margaret , Caruso Sarah , Jones Morgan , Kuick Rork , Cierpicki Tomasz , Maillard Ivan , Chiang Mark Y.
Published: March 2023

PDF file - 5445K, Figure S7. ZMIZ1 appears to regulate C-MYC expression indirectly.
Supplementary Figure 3 from SIRT1 and AMPK Mediate Hypoxia-Induced Resistance of Non–Small Cell Lung Cancers to Cisplatin and Doxorubicin
Authors: Shin Dong Hoon , Choi Yong-Joon , Park Jong-Wan
Published: March 2023

Supplementary Figure 3 PDF file 158K, Cell viability in H1299 and A549
Supplementary Figure 11 from SIRT1 and AMPK Mediate Hypoxia-Induced Resistance of Non–Small Cell Lung Cancers to Cisplatin and Doxorubicin
Authors: Shin Dong Hoon , Choi Yong-Joon , Park Jong-Wan
Published: March 2023

PDF file 365K, pAMPKα(T172), cleaved caspase-9, cleaved caspase-3 levels, TUNEL staining in xenografted tumors
Supplementary Figure 1 from SIRT1 and AMPK Mediate Hypoxia-Induced Resistance of Non–Small Cell Lung Cancers to Cisplatin and Doxorubicin
Authors: Shin Dong Hoon , Choi Yong-Joon , Park Jong-Wan
Published: March 2023

PDF file 294K, HIF-1α, SIRT1, AMPKα, and phospho-AMPKα protein levels
Supplementary Figure 4 from DKK2 Mediates Osteolysis, Invasiveness, and Metastatic Spread in Ewing Sarcoma
Authors: Hauer Kristina , Calzada-Wack Julia , Steiger Katja , Grunewald Thomas G.P. , Baumhoer Daniel , Plehm Stephanie , Buch Thorsten , da Costa Olivia Prazeres , Esposito Irene , Burdach Stefan , Richter Günther H.S.
Published: March 2023

PDF file - 3443KB, DKK2 enhances chondrogenic and osteogenic differentiation potential
Supplementary Methods from BRCA1 Deficiency Exacerbates Estrogen-Induced DNA Damage and Genomic Instability
Authors: Savage Kienan I. , Matchett Kyle B. , Barros Eliana M. , Cooper Kevin M. , Irwin Gareth W. , Gorski Julia J. , Orr Katy S. , Vohhodina Jekaterina , Kavanagh Joy N. , Madden Angelina F. , Powell Alexander , Manti Lorenzo , McDade Simon S. , Park Ben Ho , Prise Kevin M. , McIntosh Stuart A. , Salto-Tellez Manuel , Richard Derek J. , Elliott Christopher T. , Harkin D. Paul
Published: March 2023

PDF file - 124K
Supplementary Figures 1 - 6 from BRCA1 Deficiency Exacerbates Estrogen-Induced DNA Damage and Genomic Instability
Authors: Savage Kienan I. , Matchett Kyle B. , Barros Eliana M. , Cooper Kevin M. , Irwin Gareth W. , Gorski Julia J. , Orr Katy S. , Vohhodina Jekaterina , Kavanagh Joy N. , Madden Angelina F. , Powell Alexander , Manti Lorenzo , McDade Simon S. , Park Ben Ho , Prise Kevin M. , McIntosh Stuart A. , Salto-Tellez Manuel , Richard Derek J. , Elliott Christopher T. , Harkin D. Paul
Published: March 2023

PDF file - 2823K, Supplementary Figure 1. Estrogen metabolites cause DNA double strand breaks in S- phase cells. Supplementary Figure 2. BRCA1 supresses estrogen metabolite mediated DSBs and is required for their repair. Supplementary Figure 3. Estrogen and its metabolites induce DNA DSBs in a dose and time dependent manner. Supplementary Figure 4. BRCA1 suppresses estrogen metabolites induced DNA damage in BRCA1 mutant breast cancer cells. Supplementary Figure 5. BRCA1 and BRCA2 are required for repair of estrogen metabolite induced DSBs in MCF10A and MCF7 breast cells. Supplementary Figure 6. BRCA1, but not BRCA2, suppresses estrogen metabolite mediated DNA damage by repressing CYP1A1 expression in breast cells.
Supplementary Figure 2 from DKK2 Mediates Osteolysis, Invasiveness, and Metastatic Spread in Ewing Sarcoma
Authors: Hauer Kristina , Calzada-Wack Julia , Steiger Katja , Grunewald Thomas G.P. , Baumhoer Daniel , Plehm Stephanie , Buch Thorsten , da Costa Olivia Prazeres , Esposito Irene , Burdach Stefan , Richter Günther H.S.
Published: March 2023

PDF file - 5409KB, DKK2 knock-down increases apoptosis in vitro
Supplementary Figures 1-7 from Menin Epigenetically Represses Hedgehog Signaling in MEN1 Tumor Syndrome
Authors: Gurung Buddha , Feng Zijie , Iwamoto Daniel V. , Thiel Austin , Jin Guanghui , Fan Chen-Min , Ng Jessica M.Y. , Curran Tom , Hua Xianxin
Published: March 2023

PDF file - 2MB, Supplementary Fig. S1. Menin interacts directly with PRMT5.Supplementary Fig. S2. Men1 is completely excised in Men1l/l;Ubc9CreER mice after treatment with tamoxifen (4OHT). Supplementary Fig. S3. Gene Set Enrichment Analysis (GSEA) of control Men1l/l and Men1-excised islets. Supplementary Fig. S4. Menin recruits PRMT5 and its histone methylation mark, H4R3m2s, to the Gas1 promoter. Supplementary Fig. S5. Ectopic expression of PRMT5, and either wild type or mutant menin in HEK293 cells used for co-immunoprecipitation and histone methyltransferase (HMT) assays. Supplementary Fig. S6. Islet area and fasting insulin levels in Men1l/l; RipCre mice treated with either control solution or GDC 0449.Supplementary Fig. S7. Menin interacts with PRMT5, but not PRMT7. Menin was ectopically expressed in HEK293 cells, and menin immunoprecipitates were immunoblotted with either anti-PRMT5 or -PRMT7 antibodies.
Data Supplement from Chromosomal Instability Selects Gene Copy-Number Variants Encoding Core Regulators of Proliferation in ER+ Breast Cancer
Authors: Endesfelder David , Burrell Rebecca A. , Kanu Nnennaya , McGranahan Nicholas , Howell Mike , Parker Peter J. , Downward Julian , Swanton Charles , Kschischo Maik
Published: March 2023

Supplementary Figure S1. (A) Correlation (y-axis) of MKI67 expression with expression of prognostic signature genes (x-axis). Each subfigure corresponds to one of the analysed prognostic signatures and each dot represents one gene in the signature. Genes in the signature were sorted by increasing correlations (x-axis). (B) Correlation of mean meta-PCNA expression with expression of prognostic signature genes (x-axis). Red dots in A and B represent significant correlation coefficients (p < 0.05) and black dots represent correlation coefficients with p {greater than or equal to} 0.05.
Supplementary Material 8 from Androgen Glucuronidation: An Unexpected Target for Androgen Deprivation Therapy, with Prognosis and Diagnostic Implications
Authors: Grosse Laurent , Pâquet Sophie , Caron Patrick , Fazli Ladan , Rennie Paul S. , Bélanger Alain , Barbier Olivier
Published: March 2023

PDF file - 7968K, Supplementary material 8: Representative examples of immunoexpression obtained after incubation of prostate tissue microarrays with the anti-UGT2B15 or anti-UGT2B17 antibodies: Comparison cancer vs benign.
Supplementary Material 5 from Androgen Glucuronidation: An Unexpected Target for Androgen Deprivation Therapy, with Prognosis and Diagnostic Implications
Authors: Grosse Laurent , Pâquet Sophie , Caron Patrick , Fazli Ladan , Rennie Paul S. , Bélanger Alain , Barbier Olivier
Published: March 2023

PDF file - 8878K, Supplementary material 5: Representative examples of immunoexpression obtained after incubation of prostate tissue microarrays with the anti-UGT2B15, anti-UGT2B17 or anti-vimentin antibodies: Comparison Untreated vs ADTh for 3.0 and 6.0 months.
Supplementary Material 4 from Androgen Glucuronidation: An Unexpected Target for Androgen Deprivation Therapy, with Prognosis and Diagnostic Implications
Authors: Grosse Laurent , Pâquet Sophie , Caron Patrick , Fazli Ladan , Rennie Paul S. , Bélanger Alain , Barbier Olivier
Published: March 2023

PDF file - 8925K, Supplementary material 4: Representative examples of immunoexpression obtained after incubation of prostate tissue microarrays with the anti-UGT2B15, anti-UGT2B17 or anti-vimentin antibodies: Comparison Untreated vs ADTh for 1.5 and 2.0 months.
Data Supplement from Chromosomal Instability Selects Gene Copy-Number Variants Encoding Core Regulators of Proliferation in ER+ Breast Cancer
Authors: Endesfelder David , Burrell Rebecca A. , Kanu Nnennaya , McGranahan Nicholas , Howell Mike , Parker Peter J. , Downward Julian , Swanton Charles , Kschischo Maik
Published: March 2023

Supplementary Figure Legends
Supplementary Video 6 from Senescent Fibroblasts in Melanoma Initiation and Progression: An Integrated Theoretical, Experimental, and Clinical Approach
Authors: Kim Eunjung , Rebecca Vito , Fedorenko Inna V. , Messina Jane L. , Mathew Rahel , Maria-Engler Silvya S. , Basanta David , Smalley Keiran S.M. , Anderson Alexander R.A.
Published: March 2023

MOV file - 6949K, This video shows the spatio-temporal evolution of vSkin that produced Figure 6B (minimally transformed melanocytes and mildly senescent fibroblasts).
Supplementary Figure S2 from mTOR Complex 2 Is Involved in Regulation of Cbl-Dependent c-FLIP Degradation and Sensitivity of TRAIL-Induced Apoptosis
Authors: Zhao Liqun , Yue Ping , Khuri Fadlo R. , Sun Shi-Yong
Published: March 2023

Supplementary Figure S2 PDF file - 212K, Effects of PP242 on suppression of mTORC (A) and Akt (B) signaling
Supplementary Figure 5 from Mature Cytotoxic CD56bright/CD16+ Natural Killer Cells Can Infiltrate Lymph Nodes Adjacent to Metastatic Melanoma
Authors: Messaoudene Meriem , Fregni Giulia , Fourmentraux-Neves Emmanuelle , Chanal Johan , Maubec Eve , Mazouz-Dorval Sarra , Couturaud Benoit , Girod Angelique , Sastre-Garau Xavier , Albert Sebastien , Guédon Charles , Deschamps Lydia , Mitilian Delphine , Cremer Isabelle , Jacquelot Nicolas , Rusakiewicz Sylvie , Zitvogel Laurence , Avril Marie-Francoise , Caignard Anne
Published: March 2023

PDF file - 450K, Phenotype of blood NK cells from stage III melanoma patients.
Supplementary Figure 2 from Transient Antiangiogenic Treatment Improves Delivery of Cytotoxic Compounds and Therapeutic Outcome in Lung Cancer
Authors: Chatterjee Sampurna , Wieczorek Caroline , Schöttle Jakob , Siobal Maike , Hinze Yvonne , Franz Thomas , Florin Alexandra , Adamczak Joanna , Heukamp Lukas C. , Neumaier Bernd , Ullrich Roland T.
Published: March 2023

PDF file - 677KB, Multimodal imaging of tumor blood flow using 15OH2O PET in xenograft (H1975) in mice using ZD6474 as anti-angiogenic agent.
Supplementary Figure 2 from Mature Cytotoxic CD56bright/CD16+ Natural Killer Cells Can Infiltrate Lymph Nodes Adjacent to Metastatic Melanoma
Authors: Messaoudene Meriem , Fregni Giulia , Fourmentraux-Neves Emmanuelle , Chanal Johan , Maubec Eve , Mazouz-Dorval Sarra , Couturaud Benoit , Girod Angelique , Sastre-Garau Xavier , Albert Sebastien , Guédon Charles , Deschamps Lydia , Mitilian Delphine , Cremer Isabelle , Jacquelot Nicolas , Rusakiewicz Sylvie , Zitvogel Laurence , Avril Marie-Francoise , Caignard Anne
Published: March 2023

PDF file - 167K, Analyses of CD4+ Foxp3 Tregs in LN cell suspensions.
Supplementary Figure 1 from Transient Antiangiogenic Treatment Improves Delivery of Cytotoxic Compounds and Therapeutic Outcome in Lung Cancer
Authors: Chatterjee Sampurna , Wieczorek Caroline , Schöttle Jakob , Siobal Maike , Hinze Yvonne , Franz Thomas , Florin Alexandra , Adamczak Joanna , Heukamp Lukas C. , Neumaier Bernd , Ullrich Roland T.
Published: March 2023

PDF file - 721KB, Imaging of tumor cell proliferation using 18FFLT PET in PC9 tumors.
Supplementary Video 8 from Endogenous Two-Photon Fluorescence Imaging Elucidates Metabolic Changes Related to Enhanced Glycolysis and Glutamine Consumption in Precancerous Epithelial Tissues
Authors: Varone Antonio , Xylas Joanna , Quinn Kyle P. , Pouli Dimitra , Sridharan Gautham , McLaughlin-Drubin Margaret E. , Alonzo Carlo , Lee Kyongbum , Münger Karl , Georgakoudi Irene
Published: March 2023

AVI file - 1366KB, Representative 3D RENDERING E6E7 EETE.
Supplementary Video 5 from Endogenous Two-Photon Fluorescence Imaging Elucidates Metabolic Changes Related to Enhanced Glycolysis and Glutamine Consumption in Precancerous Epithelial Tissues
Authors: Varone Antonio , Xylas Joanna , Quinn Kyle P. , Pouli Dimitra , Sridharan Gautham , McLaughlin-Drubin Margaret E. , Alonzo Carlo , Lee Kyongbum , Münger Karl , Georgakoudi Irene
Published: March 2023

AVI file - 1297KB, Representative endogenous TPEF OPTICAL STACK E7 EETE.
Supplementary Video 2 from Endogenous Two-Photon Fluorescence Imaging Elucidates Metabolic Changes Related to Enhanced Glycolysis and Glutamine Consumption in Precancerous Epithelial Tissues
Authors: Varone Antonio , Xylas Joanna , Quinn Kyle P. , Pouli Dimitra , Sridharan Gautham , McLaughlin-Drubin Margaret E. , Alonzo Carlo , Lee Kyongbum , Münger Karl , Georgakoudi Irene
Published: March 2023

AVI file - 1261KB, Representative 3D RENDERING HFK EETE.
Supplementary Video 1 from Endogenous Two-Photon Fluorescence Imaging Elucidates Metabolic Changes Related to Enhanced Glycolysis and Glutamine Consumption in Precancerous Epithelial Tissues
Authors: Varone Antonio , Xylas Joanna , Quinn Kyle P. , Pouli Dimitra , Sridharan Gautham , McLaughlin-Drubin Margaret E. , Alonzo Carlo , Lee Kyongbum , Münger Karl , Georgakoudi Irene
Published: March 2023

AVI file - 1575KB, Representative endogenous TPEF OPTICAL STACK HFK EETE.
Supplementary Figure 2 from Endogenous Two-Photon Fluorescence Imaging Elucidates Metabolic Changes Related to Enhanced Glycolysis and Glutamine Consumption in Precancerous Epithelial Tissues
Authors: Varone Antonio , Xylas Joanna , Quinn Kyle P. , Pouli Dimitra , Sridharan Gautham , McLaughlin-Drubin Margaret E. , Alonzo Carlo , Lee Kyongbum , Münger Karl , Georgakoudi Irene
Published: March 2023

PDF file - 139KB, Representative histological staining of cytokeratin 14 (K14), cytokeratin 10 (K10), involucrin (INV) and loricrin (LOR) for each type of EETE.
Supplementary Figure 2 from Natural Human Plasmacytoid Dendritic Cells Induce Antigen-Specific T-Cell Responses in Melanoma Patients
Authors: Tel Jurjen , Aarntzen Erik H.J.G. , Baba Tetsuro , Schreibelt Gerty , Schulte Barbara M. , Benitez-Ribas Daniel , Boerman Otto C. , Croockewit Sandra , Oyen Wim J.G. , van Rossum Michelle , Winkels Gregor , Coulie Pierre G. , Punt Cornelis J.A. , Figdor Carl G. , de Vries I. Jolanda M.
Published: March 2023

Supplementary Figure 2 PDF file - 46K, Supplementary Figure 2 Plasmacytoid DCs acquire CCL21-driven chemotactic ability upon activation
Supplementary Figure 3 from TGF-β Mediates Homing of Bone Marrow–Derived Human Mesenchymal Stem Cells to Glioma Stem Cells
Authors: Shinojima Naoki , Hossain Anwar , Takezaki Tatsuya , Fueyo Juan , Gumin Joy , Gao Feng , Nwajei Felix , Marini Frank C. , Andreeff Michael , Kuratsu Jun-Ichi , Lang Frederick F.
Published: March 2023

PDF file - 29856K, Assays of STR polymorphism using twelve unique markers in RCS, RAT2, C6, GSC001 low, GSC001 high cells.
Supplementary Table S1 from MYC Regulation of CHK1 and CHK2 Promotes Radioresistance in a Stem Cell-like Population of Nasopharyngeal Carcinoma Cells
Authors: Wang Wen-Jun , Wu Si-Pei , Liu Jia-Bin , Shi Yong-Sheng , Huang Xue , Zhang Qian-Bing , Yao Kai-Tai
Published: March 2023

XLS file - 34K,All primers used for the constructs and PCR
Supplementary Methods from MYC Regulation of CHK1 and CHK2 Promotes Radioresistance in a Stem Cell-like Population of Nasopharyngeal Carcinoma Cells
Authors: Wang Wen-Jun , Wu Si-Pei , Liu Jia-Bin , Shi Yong-Sheng , Huang Xue , Zhang Qian-Bing , Yao Kai-Tai
Published: March 2023

PDF file - 174K,Include: Clonogenic survival assay;Patients and primary NPC samples;Ethics Statement;Quantitative real-time (qRT)-PCR;Alkaline comet assay ;Plasmids, oligonucleotides, and transfections;Luciferase assay;EdU labeling;c-MycBS prediction and ChIP assay;Immunohistochemistry
Supplementary Table 1 from mTOR Inhibitors Block Kaposi Sarcoma Growth by Inhibiting Essential Autocrine Growth Factors and Tumor Angiogenesis
Authors: Roy Debasmita , Sin Sang-Hoon , Lucas Amy , Venkataramanan Raman , Wang Ling , Eason Anthony , Chavakula Veenadhari , Hilton Isaac B. , Tamburro Kristen M. , Damania Blossom , Dittmer Dirk P.
Published: March 2023

PDF file - 17K, KS culture models
Supplementary Table 1 from Characterization of Torin2, an ATP-Competitive Inhibitor of mTOR, ATM, and ATR
Authors: Liu Qingsong , Xu Chunxiao , Kirubakaran Sivapriya , Zhang Xin , Hur Wooyoung , Liu Yan , Kwiatkowski Nicholas P. , Wang Jinhua , Westover Kenneth D. , Gao Peng , Ercan Dalia , Niepel Mario , Thoreen Carson C. , Kang Seong A. , Patricelli Matthew P. , Wang Yuchuan , Tupper Tanya , Altabef Abigail , Kawamura Hidemasa , Held Kathryn D. , Chou Danny M. , Elledge Stephen J. , Janne Pasi A. , Wong Kwok-Kin , Sabatini David M. , Gray Nathanael S.
Published: March 2023

PDF file - 401K
Supplementary Figures 1 - 4 from Characterization of Torin2, an ATP-Competitive Inhibitor of mTOR, ATM, and ATR
Authors: Liu Qingsong , Xu Chunxiao , Kirubakaran Sivapriya , Zhang Xin , Hur Wooyoung , Liu Yan , Kwiatkowski Nicholas P. , Wang Jinhua , Westover Kenneth D. , Gao Peng , Ercan Dalia , Niepel Mario , Thoreen Carson C. , Kang Seong A. , Patricelli Matthew P. , Wang Yuchuan , Tupper Tanya , Altabef Abigail , Kawamura Hidemasa , Held Kathryn D. , Chou Danny M. , Elledge Stephen J. , Janne Pasi A. , Wong Kwok-Kin , Sabatini David M. , Gray Nathanael S.
Published: March 2023

PDF file - 719K, Supplemental figure 1. Torin2 on PC-3 wide type cell line, the IB was made after 30 min treatment of drug at indicated concentrations. Supplemental figure 2. Torin1, Torin2, AZD8055 and BEZ235 on HeLa and HCT-116 cell line at different time point with a dose responsive drug treatment. Supplemental figure 3. PET-CT experiment of short term treatment of drugs. Supplemental figure 4. PDG-PET determination of drug treatment response with statistics
Supplementary Figure 5 from PTEN Loss Mitigates the Response of Medulloblastoma to Hedgehog Pathway Inhibition
Authors: Metcalfe Ciara , Alicke Bruno , Crow Ailey , Lamoureux Marlea , Dijkgraaf Gerrit J.P. , Peale Franklin , Gould Stephen E. , de Sauvage Frederic J.
Published: March 2023

PDF file - 77K, GNE-317, but not vismodegib, reduces the levels of pAKT in the PPM model. Western blot analysis of lysates from allografts, treated as indicated.
Supplementary Figure Legend and Tables 2 - 3 from Characterization of Torin2, an ATP-Competitive Inhibitor of mTOR, ATM, and ATR
Authors: Liu Qingsong , Xu Chunxiao , Kirubakaran Sivapriya , Zhang Xin , Hur Wooyoung , Liu Yan , Kwiatkowski Nicholas P. , Wang Jinhua , Westover Kenneth D. , Gao Peng , Ercan Dalia , Niepel Mario , Thoreen Carson C. , Kang Seong A. , Patricelli Matthew P. , Wang Yuchuan , Tupper Tanya , Altabef Abigail , Kawamura Hidemasa , Held Kathryn D. , Chou Danny M. , Elledge Stephen J. , Janne Pasi A. , Wong Kwok-Kin , Sabatini David M. , Gray Nathanael S.
Published: March 2023

PDF file - 69K
Supplementary Figure Legends from Automated Tracking of Nanoparticle-labeled Melanoma Cells Improves the Predictive Power of a Brain Metastasis Model
Authors: Sundstrøm Terje , Daphu Inderjit , Wendelbo Ingvild , Hodneland Erlend , Lundervold Arvid , Immervoll Heike , Skaftnesmo Kai Ove , Babic Michal , Jendelova Pavla , Sykova Eva , Lund-Johansen Morten , Bjerkvig Rolf , Thorsen Frits
Published: March 2023

PDF file - 47K, Includes movie legends
Supplementary Table 1 from Ex Vivo Activation of CD56+ Immune Cells That Eradicate Neuroblastoma
Authors: Rujkijyanont Piya , Chan Wing Keung , Eldridge Paul W. , Lockey Timothy , Holladay Martha , Rooney Barbara , Davidoff Andrew M. , Leung Wing , Vong Queenie
Published: March 2023

PDF file - 57K, Characteristics of neuroblastoma cell lines
Supplementary Figure 1 from Ex Vivo Activation of CD56+ Immune Cells That Eradicate Neuroblastoma
Authors: Rujkijyanont Piya , Chan Wing Keung , Eldridge Paul W. , Lockey Timothy , Holladay Martha , Rooney Barbara , Davidoff Andrew M. , Leung Wing , Vong Queenie
Published: March 2023

PDF File - 222K, Titration experiments for optimal CD56+:CD56− cell ratio.
Supplementary Figure Legends from MDM2 Small-Molecule Antagonist RG7112 Activates p53 Signaling and Regresses Human Tumors in Preclinical Cancer Models
Authors: Tovar Christian , Graves Bradford , Packman Kathryn , Filipovic Zoran , Xia Brian Higgins Mingxuan , Tardell Christine , Garrido Rosario , Lee Edmund , Kolinsky Kenneth , To Kwong-Him , Linn Michael , Podlaski Frank , Wovkulich Peter , Vu Binh , Vassilev Lyubomir T.
Published: March 2023

PDF file - 71K
Supplementary Figure 6 from Therapeutic PD-1 Pathway Blockade Augments with Other Modalities of Immunotherapy T-Cell Function to Prevent Immune Decline in Ovarian Cancer
Authors: Duraiswamy Jaikumar , Freeman Gordon J. , Coukos George
Published: March 2023

PDF file, 23K, Upregulation of suppressive population of MDSCs and pDCs following GVAX and FVAX vaccination, respectively.
Supplementary Figure 3 from Therapeutic PD-1 Pathway Blockade Augments with Other Modalities of Immunotherapy T-Cell Function to Prevent Immune Decline in Ovarian Cancer
Authors: Duraiswamy Jaikumar , Freeman Gordon J. , Coukos George
Published: March 2023

PDF file, 27K, Expression of PD-L1 and PD-1 by TIL Tregs.
Supplementary Figure 2 from Therapeutic PD-1 Pathway Blockade Augments with Other Modalities of Immunotherapy T-Cell Function to Prevent Immune Decline in Ovarian Cancer
Authors: Duraiswamy Jaikumar , Freeman Gordon J. , Coukos George
Published: March 2023

PDF file, 58K, Expression of PD-L1 and PD-1 in ID8 mice.
Supplementary Table 2 from Notch3 Pathway Alterations in Ovarian Cancer
Authors: Hu Wei , Liu Tao , Ivan Cristina , Sun Yunjie , Huang Jie , Mangala Lingegowda S. , Miyake Takahito , Dalton Heather J. , Pradeep Sunila , Rupaimoole Rajesh , Previs Rebecca A. , Han Hee Dong , Bottsford-Miller Justin , Zand Behrouz , Kang Yu , Pecot Chad V. , Nick Alpa M. , Wu Sherry Y. , Lee Ju-Seog , Sehgal Vasudha , Ram Prahlad , Liu Jinsong , Tucker Susan L. , Lopez-Berestein Gabriel , Baggerly Keith A. , Coleman Robert L. , Sood Anil K.
Published: March 2023

PDF file - 183K, The siRNA and Primer Sequences.
Supplementary Table 5 from Global Transcriptome Analysis of Formalin-Fixed Prostate Cancer Specimens Identifies Biomarkers of Disease Recurrence
Authors: Long Qi , Xu Jianpeng , Osunkoya Adeboye O. , Sannigrahi Soma , Johnson Brent A. , Zhou Wei , Gillespie Theresa , Park Jong Y. , Nam Robert K. , Sugar Linda , Stanimirovic Aleksandra , Seth Arun K. , Petros John A. , Moreno Carlos S.
Published: March 2023

XLSX file - 42K, Set of 894 genes with a univariate CoxPH q-value < 0.10 that were subjected to pathway enrichment and upstream analyses using Ingenuity Pathway Analysis (IPA).
Supplementary Table 4 from Global Transcriptome Analysis of Formalin-Fixed Prostate Cancer Specimens Identifies Biomarkers of Disease Recurrence
Authors: Long Qi , Xu Jianpeng , Osunkoya Adeboye O. , Sannigrahi Soma , Johnson Brent A. , Zhou Wei , Gillespie Theresa , Park Jong Y. , Nam Robert K. , Sugar Linda , Stanimirovic Aleksandra , Seth Arun K. , Petros John A. , Moreno Carlos S.
Published: March 2023

XLSX file - 9K, Prediction Model based on Clinical Variables alone, namely, tGleason score, Log(prePSA + ), pStage, Surgical Margin Status, and Age.
Supplementary Methods from Homing of Human B Cells to Lymphoid Organs and B-Cell Lymphoma Engraftment Are Controlled by Cell Adhesion Molecule JAM-C
Authors: Doñate Carmen , Ody Christiane , McKee Thomas , Ruault-Jungblut Sylvie , Fischer Nicolas , Ropraz Patricia , Imhof Beat A. , Matthes Thomas
Published: March 2023

PDF file - 84K, Methods include Flow cytometry analysis, Histological staining of mouse, JAM-B expression analysis, and statistical analysis
Supplementary Figure 1 from Combination Therapy Targeting the Chk1 and Wee1 Kinases Shows Therapeutic Efficacy in Neuroblastoma
Authors: Russell Mike R. , Levin Kirill , Rader JulieAnn , Belcastro Lili , Li Yimei , Martinez Daniel , Pawel Bruce , Shumway Stuart D. , Maris John M. , Cole Kristina A.
Published: March 2023

PDF file - 133K, Expression and activity of Wee1 is prevalent in neuroblastoma. (A) A secondary panel of neuroblastoma cell lines demonstrated Wee1 expression and activation (evidenced by phospho-Ser642) by western blot. Cdc2 activity was observed in all neuroblastoma lines. (B) A variety of adult cancer lines were tested for Wee1 phosphorylation, and were generally much lower than that seen in neuroblastoma (far right lanes)
Supplementary Figures 1 - 5 from Hypomethylating Therapy in an Aggressive Stroma-Rich Model of Pancreatic Carcinoma
Authors: Shakya Reena , Gonda Tamas , Quante Michael , Salas Martha , Kim Samuel , Brooks Jenna , Hirsch Steffen , Davies Justine , Cullo Angelica , Olive Kenneth , Wang Timothy C. , Szabolcs Matthias , Tycko Benjamin , Ludwig Thomas
Published: March 2023

PDF file - 261K, Reductions in global genomic 5mC in stromal myofibroblasts and malignant epithelial cells in progression from early to late PanIN. DNMT1 levels are reduced in human pancreatic CAFs and are dependent on cellular proliferation. The proliferation index assessed by Ki67 IHC is lower in CAFs than in malignant epithelial cells and is reduced in both components following DAC treatment of the KPC-Brca1 tumors. DAC leads to induction of mRNA expression of interferon response pathway genes. Large areas of sarcomatoid change and loss of CAFs in tumors that have escaped from growth inhibition by DAC.
Supplementary Figure Legend from Hypomethylating Therapy in an Aggressive Stroma-Rich Model of Pancreatic Carcinoma
Authors: Shakya Reena , Gonda Tamas , Quante Michael , Salas Martha , Kim Samuel , Brooks Jenna , Hirsch Steffen , Davies Justine , Cullo Angelica , Olive Kenneth , Wang Timothy C. , Szabolcs Matthias , Tycko Benjamin , Ludwig Thomas
Published: March 2023

PDF file - 95K
Supplementary Movie 3 from Tumor Suppressor NF2/Merlin Is a Microtubule Stabilizer
Authors: Smole Zlatko , Thoma Claudio R. , Applegate Kathryn T. , Duda Maria , Gutbrodt Katrin L. , Danuser Gaudenz , Krek Wilhelm
Published: March 2023

MOV file - 4174K, Speed track visualization of Movie 2, speeds between 0 to 30 microm/min are color-coded (bar on the left: min, dark blue to max, dark red).
Supplementary Methods, Figure Legend, Table 1, Figures 1-8 from Midkine Promotes Neuroblastoma through Notch2 Signaling
Authors: Kishida Satoshi , Mu Ping , Miyakawa Shin , Fujiwara Masatoshi , Abe Tomoyuki , Sakamoto Kazuma , Onishi Akira , Nakamura Yoshikazu , Kadomatsu Kenji
Published: March 2023

PDF file - 7746K, Supplementary Table S1. Sequence of primers for PCR experiments Supplementary Figure S1. mRNA expressions in the SMG of MYCN Tg mice Supplementary Figure S2. MK expression in the growing tumors of MYCN Tg mice Supplementary Figure S3. SPR assay with the RNA aptamer Apt-nc Supplementary Figure S4. In vivo AP assay with TNB1 cells Supplementary Figure S5. Soft agar assay with TNB1, YT-nu and LNCap cells. Supplementary Figure S6. The overview of TNB1 xenograft tumors Supplementary Figure S7. Soft agar and xenograft experiments with YT-nu cells Supplementary Figure S8. The attenuation of Notch2 signaling in Apt-1-treated YT-nu xenograft tumors
Supplementary Figure S5 from Ex Vivo Expansion of Highly Cytotoxic Human NK Cells by Cocultivation with Irradiated Tumor Cells for Adoptive Immunotherapy
Authors: Lim Seon Ah , Kim Tae-Jin , Lee Jung Eun , Sonn Chung Hee , Kim Kwanghee , Kim Jiyoung , Choi Jong Gwon , Choi Il-Kyu , Yun Chae-Ok , Kim Jae-Hong , Yee Cassian , Kumar Vinay , Lee Kyung-Mi
Published: March 2023

Supplementary Figure S5 PDF file - 27K, Patient year of birth, disease type, stage and sites of metastasis where applicable, for samples which were evaluated in Figure 6 for KL-1 mediated NK cell expansion are shown
Supplementary Figure 3 from Tumor Suppressor NF2/Merlin Is a Microtubule Stabilizer
Authors: Smole Zlatko , Thoma Claudio R. , Applegate Kathryn T. , Duda Maria , Gutbrodt Katrin L. , Danuser Gaudenz , Krek Wilhelm
Published: March 2023

PDF file - 1374K, Tubulin tyrosination state in NF2 negative cells.
Supplementary Figure S2 from Ex Vivo Expansion of Highly Cytotoxic Human NK Cells by Cocultivation with Irradiated Tumor Cells for Adoptive Immunotherapy
Authors: Lim Seon Ah , Kim Tae-Jin , Lee Jung Eun , Sonn Chung Hee , Kim Kwanghee , Kim Jiyoung , Choi Jong Gwon , Choi Il-Kyu , Yun Chae-Ok , Kim Jae-Hong , Yee Cassian , Kumar Vinay , Lee Kyung-Mi
Published: March 2023

Supplementary Figure S2 PDF file - 39K, A standard 51Cr release assay was performed using K562, U937 or KL-1 as target cell lines, as described in the "Materials and Methods" section. These targets were labeled with 51Cr (Perkin Elmer, Boston, MA, USA) at 50 ��Ci/5 �~ 105 cells and incubated at 5 �~ 103 cells/well with resting human NK cells at E:T ratios of 30:1, 10:1 and 3:1. Percent specific lysis was calculated as follows: 100 �~ (experimental release-spontaneous release)/(maximum release-spontaneous release)
Supplementary Figure 4 from Phosphorylation of Ribosomal Protein S6 Attenuates DNA Damage and Tumor Suppression during Development of Pancreatic Cancer
Authors: Khalaileh Abed , Dreazen Avigail , Khatib Areej , Apel Roy , Swisa Avital , Kidess-Bassir Norma , Maitra Anirban , Meyuhas Oded , Dor Yuval , Zamir Gideon
Published: March 2023

PDF file - 56K, Proliferation rate analysis.
Supplementary Figure 1 from RNA Trafficking by Acute Myelogenous Leukemia Exosomes
Authors: Huan Jianya , Hornick Noah I. , Shurtleff Matthew J. , Skinner Amy M. , Goloviznina Natalya A. , Roberts Charles T. , Kurre Peter
Published: March 2023

PDF file - 2.9MB, The detection of IGF-1R in HL-60 cell and vesicle lysates by Western blot
Supplementary Legends from Arkadia Regulates Tumor Metastasis by Modulation of the TGF-β Pathway
Authors: Briones-Orta Marco A. , Levy Laurence , Madsen Chris D. , Das Debipriya , Erker Yigit , Sahai Erik , Hill Caroline S.
Published: March 2023

Supplementary Legends PDF File - 120K, Legends for Supplementary Figures, Table, and Movies
Supplementary Figure S5 from Arkadia Regulates Tumor Metastasis by Modulation of the TGF-β Pathway
Authors: Briones-Orta Marco A. , Levy Laurence , Madsen Chris D. , Das Debipriya , Erker Yigit , Sahai Erik , Hill Caroline S.
Published: March 2023

Supplementary Figure S5 PDF File - 48K, Inactivation of Arkadia perturbs the TGF-�-regulated transcriptional response of MDA-MB-231 cells at 1h and 24h post TGF-� stimulation
Supplementary Figure 5 from Cancer-Associated Fibroblasts Expressing CXCL14 Rely upon NOS1-Derived Nitric Oxide Signaling for Their Tumor-Supporting Properties
Authors: Augsten Martin , Sjöberg Elin , Frings Oliver , Vorrink Sabine U. , Frijhoff Jeroen , Olsson Eleonor , Borg Åke , Östman Arne
Published: March 2023

PDF file - 59KB, NO and glutathione protect CXCL14-fibroblasts.
Supplementary Figure 4 from Cancer-Associated Fibroblasts Expressing CXCL14 Rely upon NOS1-Derived Nitric Oxide Signaling for Their Tumor-Supporting Properties
Authors: Augsten Martin , Sjöberg Elin , Frings Oliver , Vorrink Sabine U. , Frijhoff Jeroen , Olsson Eleonor , Borg Åke , Östman Arne
Published: March 2023

PDF file - 42KB, Nos1 is induced upon oxidative stress in NIH3T3 fibroblasts.
Supplementary Figure S1 from Arkadia Regulates Tumor Metastasis by Modulation of the TGF-β Pathway
Authors: Briones-Orta Marco A. , Levy Laurence , Madsen Chris D. , Das Debipriya , Erker Yigit , Sahai Erik , Hill Caroline S.
Published: March 2023

Supplementary Figure S1 PDF File - 109K, A mutation in the Arkadia gene in NCI-H460 cells produces a truncated protein
Supplementary Table 1 from Neuregulin Autocrine Signaling Promotes Self-Renewal of Breast Tumor-Initiating Cells by Triggering HER2/HER3 Activation
Authors: Lee Cleo Yi-Fang , Lin Yuan , Bratman Scott V. , Feng Weiguo , Kuo Angera H. , Scheeren Ferenc A. , Engreitz Jesse M. , Varma Sushama , West Robert B. , Diehn Maximilian
Published: March 2023

PDF file - 52K, Clinical information for BCA patient-derived xenografts.
Supplementary Methods from Neuregulin Autocrine Signaling Promotes Self-Renewal of Breast Tumor-Initiating Cells by Triggering HER2/HER3 Activation
Authors: Lee Cleo Yi-Fang , Lin Yuan , Bratman Scott V. , Feng Weiguo , Kuo Angera H. , Scheeren Ferenc A. , Engreitz Jesse M. , Varma Sushama , West Robert B. , Diehn Maximilian
Published: March 2023

PDF file - 73K
Supplementary Table 1 from β-Catenin Activation in a Novel Liver Progenitor Cell Type Is Sufficient to Cause Hepatocellular Carcinoma and Hepatoblastoma
Authors: Mokkapati Sharada , Niopek Katharina , Huang Le , Cunniff Kegan J. , Ruteshouser E. Cristy , deCaestecker Mark , Finegold Milton J. , Huff Vicki
Published: March 2023

PDF file - 78KB, Tumor types in Tg-beta-cats mice.
Supplementary Figure Legends from β-Catenin Activation in a Novel Liver Progenitor Cell Type Is Sufficient to Cause Hepatocellular Carcinoma and Hepatoblastoma
Authors: Mokkapati Sharada , Niopek Katharina , Huang Le , Cunniff Kegan J. , Ruteshouser E. Cristy , deCaestecker Mark , Finegold Milton J. , Huff Vicki
Published: March 2023

PDF file - 116KB
Supplementary Figure 4 from β-Catenin Activation in a Novel Liver Progenitor Cell Type Is Sufficient to Cause Hepatocellular Carcinoma and Hepatoblastoma
Authors: Mokkapati Sharada , Niopek Katharina , Huang Le , Cunniff Kegan J. , Ruteshouser E. Cristy , deCaestecker Mark , Finegold Milton J. , Huff Vicki
Published: March 2023

PDF file - 868KB, Activation of MAPK and mTOR pathways in HCCs.
Supplementary Figure 3 from β-Catenin Activation in a Novel Liver Progenitor Cell Type Is Sufficient to Cause Hepatocellular Carcinoma and Hepatoblastoma
Authors: Mokkapati Sharada , Niopek Katharina , Huang Le , Cunniff Kegan J. , Ruteshouser E. Cristy , deCaestecker Mark , Finegold Milton J. , Huff Vicki
Published: March 2023

PDF file - 1806KB, Wnt pathway and proliferation in livers of littermate control adult mice and one month old Tg-beta-cats mice.
Supplementary Figure 4 from A Preclinical Assay for Chemosensitivity in Multiple Myeloma
Authors: Khin Zayar P. , Ribeiro Maria L.C. , Jacobson Timothy , Hazlehurst Lori , Perez Lia , Baz Rachid , Shain Kenneth , Silva Ariosto S.
Published: March 2023

PDF file - 67K, The duration of bortezomib activity post-withdrawal.
Supplementary Figure 3 from A Preclinical Assay for Chemosensitivity in Multiple Myeloma
Authors: Khin Zayar P. , Ribeiro Maria L.C. , Jacobson Timothy , Hazlehurst Lori , Perez Lia , Baz Rachid , Shain Kenneth , Silva Ariosto S.
Published: March 2023

PDF file - 126K, The duration of melphalan toxicity post-withdrawal.
Supplementary Figures 1 and 2 from Effects of Notch Signaling on Regulation of Myeloid Cell Differentiation in Cancer
Authors: Cheng Pingyan , Kumar Vinit , Liu Hao , Youn Je-In , Fishman Mayer , Sherman Simon , Gabrilovich Dmitry
Published: March 2023

PDF - 1296K, The phenotype of cells in TB mice and generated from HPC in the presence of TCM (S1); Typical example of the phenotype of cells generated from HPC after 7-day culture on immobilized Dll1 or control IgG in the presence of TCM (S2).
Supplementary Figure 2 from A Preclinical Assay for Chemosensitivity in Multiple Myeloma
Authors: Khin Zayar P. , Ribeiro Maria L.C. , Jacobson Timothy , Hazlehurst Lori , Perez Lia , Baz Rachid , Shain Kenneth , Silva Ariosto S.
Published: March 2023

PDF file - 66K, Loss of membrane motion is an early event in cell death, preceding loss of membrane integrity.
Supplementary Figure 3 from Taccalonolide Binding to Tubulin Imparts Microtubule Stability and Potent In Vivo Activity
Authors: Risinger A.L. , Li J. , Bennett M.J. , Rohena C.C. , Peng J. , Schriemer D.C. , Mooberry S.L.
Published: March 2023

PDF file - 215K, High magnification electron micrographs (20,000x and 50,000x) of microtubules formed in the presence of 2 mg/ml tubulin with 10 microM AJ, PTX or LAU after chilling the microtubules at -20 degrees C for 30 min.
Supplementary Figures 1 - 4 from G-protein Inactivator RGS6 Mediates Myocardial Cell Apoptosis and Cardiomyopathy Caused By Doxorubicin
Authors: Yang Jianqi , Maity Biswanath , Huang Jie , Gao Zhan , Stewart Adele , Weiss Robert M. , Anderson Mark E. , Fisher Rory A.
Published: March 2023

PDF file - 251K, Figure S1. RGS6 is an essential mediator of Dox-induced increases in p53 in mouse atrium. Figure S2. Quantification of key apoptotic signaling proteins in ventricles of mice treated with Dox. Figure S3. Induction of RGS6 by Dox is transient and requires de novo protein synthesis. Figure S4. Schematic illustration of RGS6-mediated ventricular dysfunction induced by Dox.
Supplementary Methods from 14-3-3ζ Orchestrates Mammary Tumor Onset and Progression via miR-221–Mediated Cell Proliferation
Authors: Rehman Sumaiyah K. , Li Shau-Hsuan , Wyszomierski Shannon L. , Wang Qingfei , Li Ping , Sahin Ozgur , Xiao Yi , Zhang Siyuan , Xiong Yan , Yang Jun , Wang Hai , Guo Hua , Zhang Jitao D. , Medina Daniel , Muller William J. , Yu Dihua
Published: March 2023

PDF file - 121K
Supplementary Tables from ATIP3, a Novel Prognostic Marker of Breast Cancer Patient Survival, Limits Cancer Cell Migration and Slows Metastatic Progression by Regulating Microtubule Dynamics
Authors: Molina Angie , Velot Lauriane , Ghouinem Lydia , Abdelkarim Mohamed , Bouchet Benjamin Pierre , Luissint Anny-Claude , Bouhlel Imène , Morel Marina , Sapharikas Elène , Di Tommaso Anne , Honoré Stéphane , Braguer Diane , Gruel Nadège , Vincent-Salomon Anne , Delattre Olivier , Sigal-Zafrani Brigitte , André Fabrice , Terris Benoit , Akhmanova Anna , Di Benedetto Mélanie , Nahmias Clara , Rodrigues-Ferreira Sylvie
Published: March 2023

Supplementary Tables XLS file - 200K, Table SI : breast tumors and normal samples data; Table SII: MTUS1 expression level in invasive breast tumors collected at Institut Gustave Roussy; Table SIII: Time-course of metastasis formation
Supplementary Figure 5 from The HSP90 Inhibitor Ganetespib Synergizes with the MET Kinase Inhibitor Crizotinib in both Crizotinib-Sensitive and -Resistant MET-Driven Tumor Models
Authors: Miyajima Naoto , Tsutsumi Shinji , Sourbier Carole , Beebe Kristin , Mollapour Mehdi , Rivas Candy , Yoshida Soichiro , Trepel Jane B. , Huang Ying , Tatokoro Manabu , Shinohara Nobuo , Nonomura Katsuya , Neckers Len
Published: March 2023

PDF file - 75K, A dose range study of single agent crizotinib and ganetespib in wtMET-driven or mutant MET-driven tumor xenografts.
Supplementary Figure Legend from Chemotherapy Acts as an Adjuvant to Convert the Tumor Microenvironment into a Highly Permissive State for Vaccination-Induced Antitumor Immunity
Authors: Kang Tae Heung , Mao Chih-Ping , Lee Sung Yong , Chen Alexander , Lee Ji-Hyun , Kim Tae Woo , Alvarez Ronald D. , Roden Richard B.S. , Pardoll Drew , Hung Chien-Fu , Wu T.-C.
Published: March 2023

PDF file - 60K
Supplementary Figures 1 - 5 from miR-483-5p Promotes Invasion and Metastasis of Lung Adenocarcinoma by Targeting RhoGDI1 and ALCAM
Authors: Song Qiancheng , Xu Yuanfei , Yang Cuilan , Chen Zhenguo , Jia Chunhong , Chen Juan , Zhang Yue , Lai Pinglin , Fan Xiaorong , Zhou Xuan , Lin Jun , Li Ming , Ma Wenli , Luo Shenqiu , Bai Xiaochun
Published: March 2023

PDF file - 488KB, Supplementary Figure 1. Upregulation of miR-483-5p is correlated with the progression of human lung adenocarcinoma. Supplementary Figure 2. miR-483-5p did not affect lung tumor growth in vitro and in vivo. Supplementary Figure 3. miR-483-5p, but not miR-483-3p promotes lung cancer cell EMT in vitro. Supplementary Figure 4. Identification of putative miR-483-5p target genes in A549 cells by 2D-DGE. Supplementary Figure 5. Knockdown of ALCAM did not affect the expression levels of the EMT-related proteins.
Supplementary Figure S2 from LOX-Mediated Collagen Crosslinking Is Responsible for Fibrosis-Enhanced Metastasis
Authors: Cox Thomas R. , Bird Demelza , Baker Ann-Marie , Barker Holly E. , Ho Melisa W-Y. , Lang Georgina , Erler Janine T.
Published: March 2023

Supplementary Figure S2 PDF file - 171K, aSMA co-localisation during pulmonary fibrosis and LOX family member expression levels induced by liver fibrosis
Supplementary Pairwise Interactions 2 from Collections of Simultaneously Altered Genes as Biomarkers of Cancer Cell Drug Response
Authors: Masica David L. , Karchin Rachel
Published: March 2023

XLSX file - 835K
Supplementary Methods and Figures 1 - 4 from Collections of Simultaneously Altered Genes as Biomarkers of Cancer Cell Drug Response
Authors: Masica David L. , Karchin Rachel
Published: March 2023

PDF file - 534K, Supporting material for this manuscript includes four supplementary files: a detailed description of all methods and implementation (Supplementary methods); an excel spreadsheet containing all pairwise interactions, grouped by data type (Supplemental pairwise interactions); an excel spreadsheet containing all three-body set interactions, grouped by drug (Supplemental set interactions); and code used to produce all results from this manuscript, including detailed instructions for execution (44).
Supplementary Figure 4 from KLF5 Regulates the Integrity and Oncogenicity of Intestinal Stem Cells
Authors: Nakaya Takeo , Ogawa Seishi , Manabe Ichiro , Tanaka Masami , Sanada Masashi , Sato Toshiro , Taketo Makoto M. , Nakao Kazuki , Clevers Hans , Fukayama Masashi , Kuroda Masahiko , Nagai Ryozo
Published: March 2023

PDF file - 139KB, mRNA expression signal intensities in stem cells from the duodenum of Lgr5 Cre+ Catnblox(deltaex3) Klf5+/+ mice (x-axis, log) and Lgr5 Cre+ Catnblox(deltaex3) Klf5delta/delta mice (yaxis, log).
Supplementary Figure 3 from KLF5 Regulates the Integrity and Oncogenicity of Intestinal Stem Cells
Authors: Nakaya Takeo , Ogawa Seishi , Manabe Ichiro , Tanaka Masami , Sanada Masashi , Sato Toshiro , Taketo Makoto M. , Nakao Kazuki , Clevers Hans , Fukayama Masashi , Kuroda Masahiko , Nagai Ryozo
Published: March 2023

PDF file - 36KB, Mating strategy for generating Lgr5 Cre+ Catnb+/lox(ex3) Klf5flox/flox mice. Lgr5 Cre+ (Lgr5-EGFP-ires-CreERT2) mice had the activation of Cre recombinase, specific in Lgr5+ intestinal epithelial stem cells, by the intraperitoneal medication of Tamoxifen.