bluuebunny/crossref_metadata_2025 huggingface dataset:
Bisisocyanide cyclometallated platinum(II) complexes: synthesis, structure, photophysical properties, and mechanochromic behavior
Authors: Katkova S. A , Sokolova E. V , Kinzhalov M. A
Published: April 2024

A series of cyclometallated platinum(II) complexes [Pt(ppy){CNAr}2]X with two isocyanide ligands (Hppy = 2-phenylpyridine, Ar = C6H2-2,4,6-Me3, C6H3-2-Cl-6-Me , C6H3-2,6-Cl2, C6H4-4-NMe2, C6H4-4-Me, C6H4 4-Cl, C6H4-4-Br, C6H4-4-I, C6H4-4-CF3, C6H4-3-CF3; X = BF4, OTf) was synthesized by the reaction of the [{Pt(ppy)Cl}2] dimer with isocyanides (yield 52-70%). The structure of the resulting complexes was determined using mass spectrometry, 1H, 13C{1H}, 195Pt{1H}, 1H-1H COSY, 1H-1H NOESY, 1H-13C HSQC, and 1H-13C HMBC NMR spectroscopy in solution and solid-state CP/MAS 13C and 195Pt NMR spectroscopy, IR spectroscopy and X-ray diffraction analysis in the solid phase. The photophysical properties of the obtained complexes in the solid phase and the mechanochromic luminescence behavior were studied. In the solid phase, all synthesized compounds phosphoresce in the green or orange range of visible light, while photoluminescence quantum yields reach 26%. Green phosphors exhibit a reversible mechanochromic luminescence change achieved by mechanical grinding (green to orange) and solvent adsorption (orange to green).
Structure and stability of nickel(II) complexes with cryptand[2.2.2]
Authors: Isaeva V. A , Gamov G. A , Katolikova A. S , Pogodina E. I
Published: April 2024

The values of the stability constants of the mononuclear, protonated and binuclear complexes of nickel(II) with cryptand [2.2.2] were determined using potentiometric titration at ionic strength value µ→0 and temperature of 298 K. The structure and the most important geometric characteristics of Ni2 + cryptates were optimized via quantum chemical calculations performed in vacuo .
State of manganese atoms in La1-0.55xEu0.13xSr0.35xMnxAl1-xO3 solid solutions
Authors: Fedorova A. V , Chezhina N. V , Shilovskikh V. V
Published: April 2024

Solid solutions of lanthanum manganites in LaAlO3 doped with europium and strontium atoms are studied by the method of magnetic dilution. The magnetic clusters were found including manganese and europium atoms with ferromagnetic type of exchange interactions.
Effect of alkaline activation on the structural characteristics of nanocomposites based on carbonized chitosan and Fe-Co bimetallic nanoparticles
Authors: Vasilev A. A , Efimov M. N , Muratov D. G , Karpacheva G. P
Published: April 2024

Metal-carbon nanocomposites consisting of Fe-Co bimetallic nanoparticles uniformly dispersed in the carbon matrix were synthesized by pyrolysis of a precursor based on chitosan and metal salts in the temperature range 500-800°C. The change in the structural characteristics of the samples after activation in the presence of potassium hydroxide was studied. It was found that alkaline activation leads to an increase in the specific surface area of the nanocomposites up to 700 m2/g and in the size of metal nanoparticles, whereas the phase composition and morphology of the carbon support remain unchanged.
Solvent-Free reaction of 3,6-Diaryl-1,2,4-Triazine-5-Carbonitriles with 2-Amino-4-aryloxazoles
Authors: Rammohan A. , Shtaitz Ya. K. , Ladin E. D , Krinochkin A. P , Slepukhin P. A , Sharutin V. V , Sharafieva E. R , Pospelova T. A , Kopchuk D. S , Zyryanov G. V.
Published: April 2024

Solvent-free reaction of 3,6-diaryl-1,2,4-triazine-5-carbonitriles with 2-amino-4-aryloxazoles was studied. In this case, the formation of 3- and 4-aryl-substituted pyridines (two isomeric products) in yields up to 20 and 27%, respectively, was found. This result is different from that for the reaction of 3-(2-pyridyl)-1,2,4-triazine-5-carbonitriles with these substrates. Thus, in this case, 2-amino-4-aryloxazoles act as synthetic analogues of arylacetylenes.
Photo- And Ionochromic Diarylethenes with Receptor Fragments in The Thiazole Bridge
Authors: Podshibyakin V. A , Shepelenko E. N , Dubonosova I. V , Karlutova O. Yu. , Dubonosov A. D , Bren V. A
Published: April 2024

Diarylethenes containing coumarin and thiophene substituents in the thiazole bridge and quinoline receptor fragments were synthesized. 2-Chloroquinoline diarylethenes form colored cyclic hexadiene forms under UV light, which undergo reverse isomerization when exposed to visible light. 2-Hydroxyquinoline diarylethenes are nonphotochromic. The ionochromic effects of interaction with fluoride anions and copper(II) and nickel(II) cations were studied.
Synthesis of Ph3Sb(O2CR)2 Compounds with Unsaturated Carboxylic Acids and Use of Triphenylantimony Dicrotonate for the Production of Sb-Containing Polymers
Authors: Gushchin A. V , Maleeva A. I , Vakhitov V. R , Andreev P. V , Somov N. V
Published: April 2024

The reaction of triphenylantimony with ROOH peroxides (R = t -Bu, H) and unsaturated carboxylic acids afforded triphenylantimony dicarboxylates Ph3Sb(O2CCH=CH2)2, Ph3Sb(O2CCMe=CH2)2, Ph3Sb(O2CCH=CHMe)2, Ph3Sb(O2CCH=CHPh)2, Ph3Sb(O2CCH=CHC6H4NO2-3)2, Ph3Sb(O2CCH=CHC4H3O)2, Ph3Sb(O2CCH=CH-C6H4OMe-4)2, Ph3Sb(O2CCH=CHCH=CHMe)2, Ph3Sb(O2CCH2CH=CH2)2, p -Tol3Sb(O2CCH=CHPh)2 with yields of 35-86%. The comparison of the obtained compounds structure using the structural parameter τ (from the X-ray diffraction data), as well as the difference in the values of νas(COO) and νs(COO) (from the IR data) was investigated. In all compounds, the coordination of the antimony atom occupies an intermediate position between the trigonal-bipyramidal and tetragonal-pyramidal. In all compounds, there is an additional coordination of the antimony atom on carbonyl oxygen atoms. Intermolecular interactions in acrylate, methacrylate, crotonate and triphenylantimony sorbate with the participation of C=C double bonds of unsaturated carboxylate fragments of neighboring molecules located on top of each other were revealed. Antimony-containing transparent polymers - polymethyl methacrylate and polystyrene, which may be of practical value for the creation of new composite materials, have been synthesized on the basis of triphenylantimony dicrotonate. The molecular mass characteristics of polymers, the absorption of X-rays, UV light by the obtained polymers were measured.
Optimization of conditions for the synthesis of calyx[4]resorcinol conformers containing 4-dimethylammoniophenyl fragments on the lower rim of the molecule based on the response surface methodology using three-level box-behnken plans
Authors: Bakeeva R. F , Parfenova A. G , Shatalovav N. I , Sopin V. F , Gavrilova E. L
Published: April 2024

The response surface methodology using three-level Box-Behnken plans was applied in order to optimize the yield of the cone and chair conformers in the synthesis of calix[4]resorcinol functionalized with 4-dimethylammoniophenyl group along the lower rim. We used data from one-factor experiments in which the temperature, reaction time, and molar ratio of HCl to the reactants of the reaction mixture were varied to plot the response surfaces. The ratio of conformers was calculated based on the analysis of 1H NMR spectra of the products isolated from the reaction mixture. The adequacy of the proposed mathematical models for determining the yields of chair and cone conformations is confirmed by a high correlation coefficient ( R 0.99979). Optimal conditions were found for the maximum yield of the chair conformation (50°C, 2 h, molar ratio of HCl to reagents in the reaction mixture is 1-1.5, yield 100%). The optimal conditions for obtaining the cone conformation are: temperature 68.6°С, stirring time in the range of 2.24-6.44 h and the molar ratio of HCl to reagents in the reaction mixture is 2. Carrying out the synthesis under these conditions leads to the yield of the cone conformation in the range of 57.70-58.07%.
"2+1" Technetium and Rhenium Tricarbonyl Complexes with N,N′-Bidentate Ligands and Methyl 11-Isocyanoundecanoate
Authors: Miroslavov A. E , Sakhonenkova A. P , Tyupina M. Yu. , Sidorenko G. V
Published: April 2024

«2+1» tricarbonyl complexes [M(CO)3(N^N)CN(CH2)10COOMe]ClO4, where M = Tc or Re and N^N = 2,2′-bipridine (bipy) or 1,10-phernanthroline (phen), were prepared by reaction of [M(CO)3(N^N)(MeOH)]ClO4 with methyl 11-isocyanoundecanoate in methanol. The complexes were isolated and characterized by IR, 1H NMR spectroscopy and elemental analysis. Stability of the «2+1» tricarbolyl complexes with respect to transchelation with histidine was studied.
Magnetically Reusable Polymetallic Pd-Catalyst for Sonogashira Reaction in Ionic Liquid
Authors: Bumagin N. A
Published: April 2024

Based on magnetite modified with 3-aminopropyltriethoxysilane (APTES) hybrid materials Pd-Fe-Co-Ni/Fe3O4@Si-NH2 and Pd-Fe-Co-Ni/Fe3O4@Si-NH2@Pd were synthesized. Due to the synergistic effect, new magnetic polymetallic composites exhibit high catalytic activity in the Sonogashira reaction in an ionic liquid medium, which makes it possible to perform catalysis efficiently in the presence of 0.5 mol% of palladium. The new catalysts are easily removed from the reaction mixture using an external magnet and can be used up to 5-6 times without any visible loss of activity.
Synthesis of TiO2/Gd2O3 and TiO2/Gd2O3/Ag Nanomaterials. Application in Photocatalytic Degradation Reactions
Authors: Paromova A. A , Sinitsina A. A , Boitsova T. B , Gorbunova V. V , Vakhrushev A. Yu. , Isaeva E. I
Published: April 2024

A technique for the template synthesis of nanocrystalline titanium(IV) oxide and its modification with nanoparticles of gadolinium(III) oxide and silver has been developed. The composition and structure of the obtained materials were characterized by X-ray phase analysis and IR spectroscopy. The specific surface area and pore size distribution were determined. The photocatalytic properties of the synthesized TiO2/Gd2O3 and TiO2/Gd2O3/Ag nanomaterials were evaluated in the reaction of degradation of aqueous solutions of methyl orange upon irradiation with UV light. It was found that the introduction of gadolinium (III) oxide increases the photocatalytic activity, and the introduction of silver particles makes the photocatalyst sensitive to light with a shorter wavelength.
Synthesis of Zinc Sulfide Nanoparticles Using Pyridinium Ionic Liquids
Authors: Zhuravlev O. E , Rasskazova N. Yu. , Suratova E. S , Karpenkov A. Yu.
Published: April 2024

Zinc sulfide nanoparticles (quantum dots) were synthesized from aqueous solutions of sodium sulfide and zinc sulfate using pyridinium ionic liquids. The average sizes of zinc sulfide nanoparticles were determined by UV spectroscopy, X-ray diffraction, probe and scanning electron microscopy. The influence of the structure and concentration of pyridinium ionic liquids with the tetrafluoroborate anion of the same name on the size of zinc sulfide nanoparticles has been studied. The effect of the precursor concentration on the size of the nanoparticles formed in the ash was established.
Electronic State of Arsenic endo-atom and indices of interatomic bonds in[As@Ni12As20]3-/0, As20, Ni12As20, As@C60, and As@C70 Clusters
Authors: Semenov S. G , Bedrina M. E , Klemeshev V. A
Published: April 2024

The DFT PBE0/SDD method was used to calculate bond lengths and bond indices in As20, Ni12As20, [As@Ni12As20]3-, As@C60 and As@C70 clusters. The degrees of oxidation and reduction of the endo -atom and the shell are expressed in terms of the populations of one-electron states localized in these components of the complexes. Each As atom in clusters has a entirely localized lone electron pair. The arsenic atom inside fullerenes retains the electronic configuration and spin of the ground state of the free As atom. Inside the [Ni12As20]6- shell, it has an oxidation state of 3+. There is no covalent bond between the endo -atom and the shell in clusters. The bond indices refute the opinion about the “onion” structure of [As@Ni12@As20]3-: the nickel atoms are not bonded to each other, the As-As bond indices are three times lower than in As20.
Synthesis and cytotoxic activity of novel chalcone analogues with pyridine-2,4(1H,3H)-dione fragment
Authors: Khlebnicova T. S , Rubinov D. B , Baranovsky A. V , Lakhvich F. A , Pashkovsky F. S , Chukarina T. V , Ogurtsova S. E
Published: April 2024

New heterocyclic chalcone analogues with pyridine-2,4(1 Н ,3 Н )-dione fragment were synthesized by the condensation reaction of 3-acetylpyridine-2,4(1 H ,3 H )-diones with different aromatic aldehydes in pyridine in the presence of a catalytic amount of piperidine and acetic acid. Structures of the synthesized compounds were confirmed by of IR, 1H, 13C NMR spectroscopy methods and two-dimensional NMR spectroscopy methods and elemental analysis data. Cytotoxic activity of the series of obtained compounds was investigated in vitro against human cell lines of breast cancer (MCF-7) and liver cancer (Hep G2).
Mechanism of chlorotriflamidation of vinylsilanes with N,N-dichlorotriflamide
Authors: Chipanina N. N , Oznobikhina L. P , Ushakova I. V , Shainyan B. A
Published: April 2024

The mechanism of the reaction of vinylsilanes with N , N -dichlorotriflamide and the effect of a substituent at the silicon atom on the reaction course and on the charge distribution in substrates and their carbon analogues were studied by DFT method. The C=C bond in vinylsilanes and alkenes is polarized in the opposite way. The reaction proceeds in two stages: chlorination of the substrate with the formation of a chloronium ion, and its opening at the Cβ-Cl bond by the N -chlorotriflamide anion. Transition states of two stages were calculated. The reaction products are hydrolyzed to NH-derivatives; their IR spectra and supramolecular structure, including cyclic and linear dimers, calculated in the gas phase and in a polar medium, were studied.
Synthesis, structure, and thermal expansion of BiCr2(PO4)3, SbCr2(PO4)3 and Bi1-xSbхCr2(PO4)3 solid solutions
Authors: Pet'kov V. I , Lavrenov D. A , Asabina E. A
Published: April 2024

The manifestations of the Bi1- x Sb x Cr2(PO4)3 system with the α-CaMg2(SO4)3 structure were obtained and characterized by the evaporation of salt solutions with heat treatment. Refinement of the Rietveld method for the structure of BiCr2(PO4)3 ( x = 0) and SbCr2(PO4)3 ( x = 1) showed that the [Cr2(PO4)3]3∞ framework is formed by CrO6 octahedra doubled by faces, PO4 tetrahedra are between the dependences, attached to the octahedrons by oxygen vertices, the voids of the framework are populated by six-coordinated bismuth or antimony atoms. By varying the composition of the Bi1- x Sb x Cr2(PO4)3 solid solution everywhere, it is possible to obtain materials with low thermal expansion coefficients: 0.5×10-6 ≤ α av ≤ 1.9×10-6 °C-1.
Biocompatible microemulsions based on oleic acid modified with piperidinium surfactants
Authors: Mirgorodskaya A. B , Kushnazarova R. A , Lenina O. A , Petrov K. A , Zakharova L. Ya.
Published: April 2024

A number of microemulsions based on oleic acid and Tween 80, modified with piperidinium surfactants, have been obtained and characterized. The effect of additives on the size, stability, and solubilization effect of the formed systems with respect to hydrophilic (rhodamine B) and hydrophobic (indomethacin) substances was studied. By varying the ratio of components, it was possible to form microemulsions that differ greatly in viscosity: from easy-flowing compositions to gels. The kinetic parameters describing release process of substrates from microemulsions have been obtained. In vivo tests of the anti-inflammatory action of microemulsions loaded with indomethacin have shown that the presence of piperidinium surfactants enhances the therapeutic effect of the drug. In vivo tests of the anti-inflammatory action of microemulsions loaded with indomethacin have shown that the presence of piperidinium surfactants enhances the therapeutic effect of the drug.
Synthesis, anticholinesterase and anti-radical activity of 2,3,5-trisubstituted 4H-imidazol-4-ones, green fluorescent protein chromophore analogues
Authors: Topuzyan V. O , Tosunyan S. R , Makichyan A. T , Hakobyan E. H , Galstyan L. Kh. , Hovhannisyan A. A
Published: April 2024

The one-pot synthesis of N -substituted α,β-dehydrotyrosyl dipeptides was carried out by the azlactone method. The target dipeptides were obtained in good yields (53-79%). From the latter, 2,3,5-trisubstituted 4-imidazolones were obtained using 1,1,1,3,3,3-hexamethyldisilazane as a dehydrating agent. It was found that in the case of β-alanine-containing peptides, abstraction of the methyl ester of acrylic acid and the formation of 2,5-disubstituted 4-imidazoline were observed. Antiradical and anticholinesterase properties of the synthesized compounds were studied. Docking analysis was carried out for both some dipeptides and imidazole-4-ones.
Synthesis and effect of substituted pyrido[2,3-d]pyrimidine-2,4-diones on In Vitro tumor dna methylation
Authors: Isakhanyan A. U , Hakobyan N. Z , Hovasyan Z. A , Nersesyan L. E , Aharonyan A. S , Danielyan I. S , Panosyan H. A , Harutyunyan A. A
Published: April 2024

Reaction of 3-diethylamino-1-aryl-, 3-diethylamino-1-aryl-2-phenyl(4-halophenyl)propane-1-ones hydrochlorides with 6-amino-1,3-dimethyluracil results in heterocyclization products, namely 1,3-dimethyl-7-aryl-5,6dihydro-1 H -pyrido[2,3- d ]pyrimidine-2,4-diones, 1,3-dimethyl-7-aryl-6-phenyl(4-halophenyl)-5,6-dihydro1 H -pyrido[2,3- d ]pyrimidine-2,4-diones and 1,3-dimethyl-7-aryl-6-phenyl-(4-halophenyl)-1 H -pyrido[2,3- d ] pyrimidine-2,4-diones. The effect of the synthesized compounds in vitro tumor DNA methylation was studied.
Mass-spectrometric study of substituted (β-hydroxy-, β-acetoxy)sulfides and -sulfones of 1,3-dioxepane series using electron ionization
Authors: Shamsutdinova L. R , Musin R. Z , Paveliev R. S , Rizvanov I. Kh. , Dimukhametov M. N
Published: April 2024

The electron ionization mass spectra of substituted (β-hydroxy)sulfides, -sulfones, and their corresponding acetates of the 1,3-dioxepane series were studied. The main regularities in the pathways of fragmentation of their molecular ions were revealed. It was shown that during electron ionization, the main directions of decomposition of the studied compounds are due to the elimination of substituents in the 1,3-dioxepane ring. For 6-phenylthio-1,3-dioxepanes and 6-phenylsulfonyl-1,3-dioxepanes, the formation of ions associated with the breaking of C-S bonds with charge localization on the sulfur-containing fragment is observed.
Synthesis of ethyl 2-methyl-4-(diethoxyphosphoryl)4,7-dihydro-5H-thiopyrano[3,4-b]furan-5-carboxylate and its functionalization at the position 3
Authors: Pevzner L. M , Ostrovskaya A. A , Petrov M. L , Stepakov A. V
Published: April 2024

Ethyl 2-methyl-4-(diethoxyphosphoryl)-4,7-dihydro-5 Н -thiopyrano[3,4- b ]furan-5-carboxylate was synthesized. It was shown that at elevated temperatures it is acetylated in presence of tin tetrachloride and chloromethylated with paraformaldehyde-hydrogen chloride system in the presence of zinc dichloride at the positon 3 of heterocyclic system. Reaction of chloromethyl derivative with N -, S - and О -nucleophiles were studied.
Synthesis and extraction properties of 4,5-diphosphorylated triazoles
Authors: Turanov A. N , Karandashev V. K , Artyushin O. I , Smirnova E. V , Brel V. K
Published: April 2024

A method for the synthesis of 4,5-diphosphorylated 1,2,3-triazoles has been developed, and the extraction of U(VI), Th(IV), and lanthanides(III) from nitric acid solutions by them was studied. A synergistic effect was found in the extraction of metal ions with mixtures of 4,5-diphosphorylated 1,2,3-triazoles and dinonylnaphthalenesulfonic acid. The stoichiometry of the extracted complexes was determined, and the influence of the structure of the extractant and the concentration of HNO3 in the aqueous phase on the efficiency of the extraction of metal ions into the organic phase was considered. It was established that 4,5-diphosphorylated 1,2,3-triazole with the octyl substituent at nitrogen atom has the highest extraction ability with respect to actinides and lanthanides in nitric acid media.
Synthesis and study of dense materials in the Zr–Al–C system
Authors: Arlashkin I. E , Perevislov S. N , Stolyarova V. L
Published: April 2024

The initial powders Zr, Al, C and Zr, Al, Sc were used for the synthesis of MAX phases of the composition Zr2AlC and Zr3AlC2. The highest content (50.4 vol%) of the MAX phase Zr3AlC2 was obtained using the initial powders Zr/Al/Zr in the ratio of components 1:1.5:2 with the addition of 5 vol% Al. The optimal temperature for the synthesis of a material based on the MAX phase Zr2AlC is 1525° C, a material based on Zr3AlC2 is 1575°C. The structure of the synthesized MAX materials obtained includes elongated grains of the composition Zr2AlC and Zr3AlC2, which determines their high strength. Zirconium carbide, as an intermediate phase, is always present in the final products. Due to the large evaporation of aluminum, the ZrO2 phase is also present in the synthesis products. Excess aluminum contributes to the greatest formation of Zr2AlC and Zr3AlC2 phases during synthesis.
Peculiarities of oxidation of nanoporous iron produced by ferromanganese dealloying in molten salt
Authors: Rozhentsev D. A , Pershina S. V , Petrova S. A , Tkachev N. K
Published: April 2024

A wuestite phase metastable at room temperature in the form of a whisker conglomerate was found on the surface of nanoporous iron obtained by electrochemical dealloying (selective anodic dissolution of a less noble metal) of ferromanganese. The features of the further oxidation of iron by TG-DSC and Х-ray phase analysis with a temperature sweep were studied. A wide range of coexistence of three forms of iron oxides and relative stability of the magnetite phase up to 900°C were described.
Enaminoketones - functional derivatives based on 7-hydroxy-3′,3′-dimethyl-3′H-spiro[chromen-2,1′-isobenzofuran]-8-carbaldehyde with aromatic amines. physicochemical studies and biological activity
Authors: Nguyen X. T , Zantman A. A , Bulanov A. O , Nguyen T. T.T , Tran L. D , Vu H. D , Duong B. N , Lazarenko V. A , Shcherbakov I. N
Published: April 2024

This research focuses on studying derivatives of 2-oxaindane spiropyran by its condensation with aromatic amines. The results showed that all the synthesized compounds are enaminoketones form in both solution and solid state. This is explained by the fact that during the formation of Schiff bases, the proton of the 7-hydroxyl group of the benzopyran part migrates to the azomethine nitrogen, which leads to the transition of the cyclic form of spiropyran into the corresponding enaminoketone. In the DMSO solution, the enaminoketones dynamic equilibrium of the E , Z -isomeric forms were observed. The structure of enaminoketone based on 3,4-dimethylaniline was proved by the X-ray diffraction method. The synthesized compounds were studied for their in vitro anticancer activity against human hepatocellular carcinoma (HepG2), breast carcinoma (MCF-7), lung cancer (A549), and carcinoma cells (KB). Enaminoketone with R = 3,4-СH3Ph is characterized by the highest activity, with IC50 values of 13.38 μM (KB). The results in vitro antioxidant activity test using 1,1-diphenyl-2-picrylhydrazyl (DPPH) indicated that enaminoketones were inactive.
Synthesis and study of some properties of new tetrazole-containing derivatives of morpholin-4-yl-1,3,5-triazine and 4-methylpiperidin-1-yl-1,3,5-triazine
Authors: Mykolaichuk O. V , Protas A. V , Popova E. A , Lutsev M. D , Smirnov E. Yu. , Golotin V. A , Ostrovsky V. A , Kornyakov I. V , Semenov K. N
Published: April 2024

New tetrazole-containing derivatives of morpholin-4-yl-1,3,5-triazine and 4-methylpiperidin-1-yl-1,3,5-triazine were synthesized. Cytotoxic activity of the compounds obtained against human liver tumor cell lines Huh-7 and human lung A549 was studied by the MTT test. It was shown that these substances do not exhibit a pronounced cytotoxic effect. The most significant antitumor activity was shown by 1,3,5-triazine containing 5-phenyltetrazol-2-ylacetohydrazide fragment and 4-methylpiperidine ring as substituents, as well as 1,3,5-triazine containing 5-methyl-1 H -tetrazol-1-ylacetohydrazide fragment and two morpholine rings. For these compounds, the interaction with DNA was studied by UV spectroscopy. For N ’-(4,6-dimorpholino-1,3,5-triazin-2-yl)-2-(5-methyl-1 H -tetrazol-1-yl)acetohydrazide, the DNA binding constant was determined ( K bin 9.02× 104 M.-1) and studied the ability to inhibit the tyrosine kinase domain of surface receptors. It was shown that the studied tetrazole-containing derivatives of 1,3,5-triazine do not exhibit antioxidant properties with respect to NO-radicals and do not cause photoinduced hemolysis.
Structure and acid-base properties of 1-propylimidazole-4,5-dicarboxylic acid
Authors: Brusina M. A , Lysova S. S , Oskorbin A. A , Ramsh S. M
Published: April 2024

NMR spectra of 1-propylimidazole-4,5-dicarboxylic acid in DMSO- d 6 were studied. It was revealed that it presents in a zwitterion form in solution. The ionization constants in water were determined and their attribution to the certain sites was performed, at that for the deprotonation constants, the correctness of the attribution was confirmed by calculations. Based on the results of calculations, the preferred zwitterion and monoanion forms of 1-propylimidazole-4,5-dicarboxylic acid were selected from several alternative structures.
Synthesis of new symmetrical diamidophosphates based on meta-phenylenediamine under microwave irradiation
Authors: Kuandykova A. B , Dzhiembaev B. Zh. , Burilov A. R , Akylbekov N. I , Chugunova E. A , Dobrynin A. B , Abyzbekova G. M
Published: April 2024

A new series of diphosphorylated amidophosphates was obtained as a result of the reaction of meta -phenylenediamine with dialkylphosphites in the presence of CCl4 and triethylamine (Atherton-Todd reaction) under microwave irradiation. Structure of all the obtained amidophosphates was established on the basis of 31P, 1H, 13C NMR, IR spectroscopy and mass spectrometry methods, as well as single crystal X-ray diffraction and elemental analysis data.
Structural correlations of complexation of apple pectin with imidazole and L-histidine methyl ester
Authors: Mudarisova R. Kh. , Kukovinets O. S , Kolesov S. V
Published: April 2024

The thermodynamic and structural study of the complex formation of apple pectin with structural analogs of histidine (imidazole and its methyl ester) was carried out using spectral methods. The composition, stability constants of the complexes, and standard thermodynamic characteristics (Δ G° , Δ H° , Δ S° ) of the complex formation process were determined. The decisive contribution of the imidazole fragment of the amino acid to the stability of the pectin-histidine complex is shown. The esterification of the carboxyl group of histidine, its conversion into methyl ester, has an insignificant effect on the efficiency of complex formation with pectin, leading only to a slight increase in binding.
Supramolecular systems based on sodium alginate and viologen calyx[4]resorcinol for encapsulation of hydrophobic compounds
Authors: Kashapov R. R , Razuvaeva Yu. S. , Ziganshina A. Yu. , Sapunova A. S , Voloshina A. D , Salnikov V. V , Zakharova L. Ya.
Published: April 2024

The work is devoted to the study of a supramolecular system based on viologen calix[4]resorcinol and sodium alginate in an aqueous medium using a set of physicochemical methods. It was established that sodium alginate and viologen calix[4]resorcinol form stable nanoparticles capable of encapsulating hydrophobic biologically active substances in the range of macrocycle:polymer concentration ratios from 1:2 to 1:10. The study of the cytotoxic properties of these nanoparticles in the presence of encapsulated substrates showed an increase in the selectivity of the action of quercetin and oleic acid against M-HeLa tumor cells by 2.47 and 1.14 times, respectively.
Sulfur solubility in sulfolane electrolytes for lithium-sulfur batteries
Authors: Karaseva E. V , Khramtsova L. A , Shakirova N. V , Kuzmina E. V , Kolosnitsyn V. S
Published: April 2024

The solubility of sulfur in sulfolane and sulfolane solutions of lithium salts [LiBF4, LiClO4, LiPF6, LiSO3CF3 and LiN(SO2CF3)2], promising electrolytes for lithium-sulfur batteries, was determined by UV-vis spectroscopy. It was found that the solubility of sulfur in sulfolane at 30°C is 82.0 mM, and in sulfolane solutions of lithium salts (1 M) is 4-9 times lower than in pure sulfolane. The dependence of sulfur solubility on the concentration of lithium salts is not linear, it is 32.9 and 5.8 mM for sulfolane solutions of 0.5 М LiClO4 and 2.35 M LiClO4, respectively.
Sinthesis and biological properties of N-acylaminoacryloylhistamines and the corresponding 4-arylideneimidazol-5(4H)-ones
Authors: Topuzyan V. O , Hovhannisyan A. A , Tosunyan S. R , Makichyan T. T , Hovhannisyan N. A , Shahkhatuni A. A
Published: April 2024

The reaction of unsaturated 4-arylidenoxazol-5(4 H )-ones with 2-(1 H -imidazol-4-yl)ethan-1-amine dihydrochloride was used to synthesize and describe the physicochemical characteristics of histamine N -acyl derivatives containing α,β-dehydroamino acids residues, as well as the corresponding 4-arylidenimidazol-5(4 H )-ones. Anticholinesterase and antiradical properties of the synthesized compounds were studied. It was revealed that the studied substances have anticholinesterase activity both acetylcholinesterase and butyrylcholinesterase and have almost no antiradical activity.
7-(2-aryl-1-cyanovinyl)-1,2,3,4-tetrahydropyrazolo[1,5-a][1,3,5]triazine-8-carbonitriles: synthesis and biological activity
Authors: Stepanova S. F , Semenova A. M , Dotsenko V. V , Strelkov V. D , Temerdashev A. Z , Gasyuk O. A , Volchenko N. N , Aksenov N. A , Aksenova I. V
Published: April 2024

A new method was proposed for the preparation of 5-amino-3-(cyanomethyl)-1 H -pyrazole-4-carbonitrile by reacting the potassium salt of malononitrile dimer with hydrazinium sulfate. The reaction of 5-amino-3(cyanomethyl)-1 H -pyrazole-4-carbonitrile with aromatic aldehydes in the presence of catalytic amounts of morpholine leads to the formation of Knoevenagel condensation products. Aminomethylation of the resulting ( Z )-5amino-3-(2-aryl-1-cyanovinyl)-1 H -pyrazole-4-carbonitriles with primary aromatic amines and excess aqueous HCHO in refluxing DMF leads to the formation of 7-(2-aryl-1-cyanovinyl)-1,2,3,4-tetrahydropyrazolo[1,5- a ][1,3,5]triazine-8-carbonitriles. Bioavailability parameters were studied in silico , and possible protein targets were predicted by protein-ligand docking. In an in vitro experiment on cultures of E. coli , S. aureus and B. pumilis , 5-amino-3-(cyanomethyl)-1 H -pyrazole-4-carbonitrile does not show any noticeable antibacterial effect. At the same time, three compounds of the pyrazolo[1,5- a ][1,3,5]triazine series showed a pronounced antidote effect against the herbicide 2,4-D on sunflower seedlings in a laboratory experiment, for one compound a noticeable growth-stimulating effect was noted.
A new variation of the sila-Sonogashira reaction
Authors: Spesivaya E. S , Lupanova I. A , Konshina Dz. N. , Sukhno I. V , Konshin V. V
Published: April 2024

A new variation of the sila-Sonogashira reaction was proposed, which involves the use of tetraalkynylsilane as an alkynylating reagent. It was found that the reaction proceeds most efficiently at an equivalent ratio of tetraalkynylsilane and iodoarene catalyzed by 5 mol% Pd(PPh3)2Cl2 and 10% CuI in the presence of 10-fold amount of triethylamine in chloroform. The title tolanes yields are 58-85%.
Development of a complex of doxorubicin with nanoparticles based on sodium alginate and viologen calix[4]resorcinol to increase selectivity of cytotoxic action
Authors: Kashapov R. R , Razuvaeva Yu. S. , Ziganshina A. Yu. , Sapunova A. S , Voloshina A. D , Salnikov V. V , Zakharova L. Ya.
Published: April 2024

A biocompatible supramolecular system based on sodium alginate and viologen calix[4]resorcinol for encapsulation of doxorubicin hydrochloride (DOX) was obtained. Using a set of physicochemical methods, the polymer- macrocycle ratio was found, at which stable nanoparticles are formed, and their morphological characteristics were determined. It was shown that with an increase in the concentration of calix[4]resorcinol, the size of nanoparticles increases and the zeta potential changes from negative to positive values. It was established that the most optimal supramolecular system for DOX binding is a composition with a macrocycle-polymer ratio of 1:50, and a change in the ratio of components can initiate drug release. The effect of encapsulated DOX on the physicochemical and biological properties of the supramolecular system was shown.
Effect of the nature of nitrogen-containing bases on their catalytic activity in the reaction of zinc compleх formation with tetra(4-tert-butyl-5-phenylsulfanyl)phtalocyanine in benzene
Authors: Petrov O. A , Mayzlish V. E
Published: April 2024

The catalytic action of the cyclic and acyclic organic nitrogen bases on the complex formation between zinc and tetra(4- tert -buthyl-5-phenylsulfanyl)phtalocyanine in benzene was studied. The acid-base interaction was shown to precede the complexation and to play a key role in it. The scheme of complex formation of zinc with tetra(4- tert -buthyl-5-phenylsulfanyl)phtalocyanine in the system containing also organic nitrogen base and benzene was given. The relationship between catalytic activity of the base and its ability to accept proton as well as structure was described.
Functionalization of graphene fluoride with 2-phenylbenzimidazole
Authors: Matveev Z. A , Kholkhoev B. Ch. , Makotchenko V. G , Ivanova M. N , Fedorov V. E , Burdukovskii V. F
Published: April 2024

The interaction of graphene fluoride with 2-phenylbenzimidazole afforded a new benzimidazole-functionalized graphene material. It was shown that carrying out the reaction in sulfolane in the presence of pyridine provides a higher degree of functionalization. The formation of the target product was confirmed by elemental analysis, IR and Raman spectroscopy.
Synthesis of N-Substituted Morpholine C60-Fullerene Adducts in the Presence of LiOH and Lead(IV) Acetate
Authors: Kinzyabaeva Z. S , Fazletdinova Z. N
Published: April 2024

A N -phenyl-substituted morpholine adduct of C60 fullerene, 1,9-[4′-phenylmorpholine]-1,9-dihydro-(C60-Ih) [5,6]fullerene, was obtained for the first time with a yield of 56% in the reaction of 2-phenylaminoethanol with fullerene in the presence of LiOH and Pb(OAc)4 at room temperature for 1 h. The amino alcohol with an electron donor group (2-methylaminoethanol) in the reaction with fullerene showed a higher reactivity: the product 1,9-[4′-methylmorpholine]-1,9-dihydro-(С60-Ih)[5,6]fullerene was isolated in 68% yield. The presence of electron-withdrawing groups at the α- or β-carbon atom relative to the nitrogen atom in amino alcohols [carboxylic (2-amino-3-hydroxypropanoic acid, serine) or carbonyl (aminoacetic acid) groups] does not contribute to the reactions with fullerene under the studied conditions.
Effect of amino acid fragments in tetraphenylporphin derivatives on the Ph-dominance interval of dication porphyrin
Authors: Ivanova Yu. B. , Khrushkova Yu. V. , Pukhovskaya S. G , Lukanov M. M , Syrbu S. A
Published: April 2024

The effect of amino acid fragments in tetraphenylporphin derivatives on the pH range of porphyrin dominance as a dication was studied. For this purpose, the protonation processes of unsymmetrically substituted derivatives of 5,10,15,20-tetraphenylporphyrin: 5-(4′-aminophenyl)-10,15,20-triphenylporphine, 5-(4′-tyrosinylamidophenyl)-10,15,20-triphenylporphine and 5-(4′-glycinacylaminophenyl)-10,15,20-triphenylporphine were analyzed in acetonitrile. It was found that in acidic acetonitrile solutions the pH range of dominance of the doubly protonated form depends on the nature of the substituent in the para -position on the periphery of the phenyl fragment of the porphyrin ring: electron-donating substituents expand the pH range of dominance of the porphyrin in the dication form, while electron-withdrawing substituents decrease it. The calculation of the energies of the molecular orbitals of the studied compounds by the DFT method with the B3LYP/cc-pVDZ set showed good agreement between the experimental results and the calculations.
Application of silver(i) dicyano-[3-cyano-4-(4-dimethylaminophenyl)6-(2-hydroxyphenyl)pyridin-2-yl]methanide as a reagent for the quantitative determination of biothiols
Authors: Bardasov I. N , Chunikhin S. S , Alekseeva A. U
Published: April 2024

An approach for the quantitative fluorimetric determination of a number of anions and thiols, including glutathione and cysteine, based on the use of a silver salt with an organic anion based on nicotinonitrile containing a tricyanobutadiene fragment was proposed.
Synthesis of 5-aryl-4-acyl-3-hydroxy-1-carboxymethyl3-pyrroline-2-ones by hydrolysis of 5-aryl-4-acyl-3-hydroxy1-cyanomethyl-3-pyrroline-2-ones
Authors: Gein V. L , Buldakova E. A
Published: April 2024

5-Aryl-4-acyl-3-hydroxy-1-carboxymethyl-3-pyrroline-2-ones were obtained by acid hydrolysis of 5-aryl-4-acyl3-hydroxy-1-cyanomethyl-3-pyrrolin-2-ones. Structure of the obtained compounds was confirmed by spectral data (IR, 1Hб and 13С NMR) and authentic synthesis.
Synthesis and spectral characteristics of hydrazinocarbonothioyl derivatives of maleopimaric acid
Authors: Vafina G. F , Poptsov A. I
Published: April 2024

Reaction of acyl isothiocyanates of 2-allyl- and 2-benzylmaleopimarimides with 3-carboxy- and 2,4-dinitrophenylhydrazines and hydrazides of some aromatic acids (benzoic, 4-hydroxy- and 4-methoxybenzoic, nicotinic, isonicotinic) furnished linear hydrazinocarbonothioyl derivatives of these maleopimarimides in high yields. Structure of the synthesized compounds was determined by 1H,13C, 1H-13C HSQC, 1H-13C HMBC, COSY, NOESY, and 1H-15N HMBC NMR spectroscopy methods.
Synthesis and some properties of new bromo derivatives of isobornylphenols
Authors: Kolegova T. A , Chukicheva I. Yu. , Shevchenko O. G , Kutchin A. V
Published: April 2024

We determined optimal conditions to brominate various isobornyl phenols with molecular bromine and N -bromosuccinimide as well as studied oxidative bromination of them with KBr-Oxone®. For obtained brominated derivatives, as isobornylphenols, an assessment of erythrotoxicity, membrane-protective and antioxidant activity was performed using in vitro models. Halogen derivatives of isobornylphenols containing a bromine atom in the para -position and an alkyl fragment in the ortho -position relative to the phenolic hydroxyl group showed high antioxidant activity in the model of oxidative hemolysis of erythrocytes.
Synthesis of new efficient fluorophores of thieno[2,3-b]pyridine series
Authors: Alekseeva A. U , Ievlev M. Yu. , Zinovieva E. G , Ershov O. V , Ershova A. I , Bardasov I. N
Published: April 2024

The reaction of 4-amino-6-aryl-2-halopyridine-3,5-dicarbonitriles with thioglycolic acid ethyl ester was used to synthesize a series of new efficient fluorophores of thieno[2,3- b ]pyridine series. The long-wavelength absorption bands of DMSO solutions of the prepared compounds are at the boundary of the UV and visible regions of the spectrum (λabs 375-388 nm) and show an ambiguous influence of the substituent electronic effect, that was explained by quantum chemical calculations. The emission maxima are in the yellow-green region (λem 490- 510 nm) and they are blue-shifted in the presence of electron donor groups with slightly increasing intensity (Φem 37.8-60.6%). It was found that the nitro group presence causes a complete photoluminescence quenching both in solution and in the solid state. In addition, the position of the emission maximum (λem 473-505 nm) and its intensity (Φem 3.6-72.7%) strongly depend on the polarity and the basic properties of the medium, that was established using the Catalan empirical model.
Rhodamine 6G based molecular ion-active switches of optical and fluorescent properties
Authors: Shepelenko E. N , Podshibyakin V. A , Dubonosova I. V , Karlutova O. Yu. , Dubonosov A. D , Bren V. A
Published: April 2024

A series of rhodamine 6G derivatives with o -hydroxyarylime substituents was synthesized. The obtained compounds in acetonitrile are capable of H+ induced transformation of the spirolactam form into open form. The process is accompanied by the formation of new long-wave absorption maxima at 527-529 nm and fluorescence bands at 557-560 nm. The compound containing 2-hydroxy-4-dimethylaminophenyl substituent in the presence of Zn2+ cations displays switching of emission at 429 nm. This fluorescence is quenched selectively by the CN- anion. Copper(II) cations cause the transformation of the spirostructure of rhodamine with a 2-hydroxy-3- tert -butylbenzofuran group into an open form. Isomerization occurs with a chromogenic naked-eye effect - a change in the color of the solution from pale yellow to pink and the appearance of fluorescence at 556 nm. The observed ion-induced spectral transformations can be used in design of optical and fluorescent chemosensors.
Extraction of ree(III) from nitric acid media with tetraoctyldiglycolamide into trioctylammonium bis[(trifluoromethyl)sulfonyl]imide
Authors: Turanov A. N , Karandashev V. K , Khvostikov V. A , Baulin V. E , Baulin D. V
Published: April 2024

The effect of trioctylammonium bis[(trifluoromethyl)sulfonyl]imide ionic liquid on the extraction of REE(III) with tetraoctyldiglycolamide from nitric acid solutions was studied. It was found that in the presence of an ionic liquid in the organic phase, the efficiency and selectivity of the extraction of metal ions from nitric acid solutions increases significantly. The influence of the acidity of the aqueous phase on the change in the distribution ratios of REE(III) was considered, and the stoichiometry of the extractable complexes was determined.
Reaction of o-formylbenzoic acid with hydrazides of (iso)niconitic and hydroxybenzoic acids
Authors: Nurkenov O. A. , Fazylov S. D. , Kulakov I. V. , Seilkhanov T. M. , Mendibayeva A. Zh. , Syzdykov A. K. , Kabieva S. K.
Published: April 2024

The reaction of nicotinic and isonicotinic acid hydrazides with o -formyl benzoic acid in ethanol led to the formation of the corresponding hydrazones. It was found that o -formyl benzoic acid reacted in aldehyde form with hydrazides to form hydrazones. When heated in acetic anhydride, the latter are smoothly cyclized into 3-acetoxyisoindoline-1-ones. Structure of the synthesized compounds was proved by 1H and 13C NMR spectroscopy data. Antiradical and antiviral activity of the synthesized hydrazones and 3-acetoxyisoindoline-1-ones was studied. A compound with a wide spectrum of virus-inhibiting action against strains of the A virus was identified.
Synthesis and phosphonylation of 6-methyl-4-aryl-2-thio-1,2,3,4-tetrahydropyrimidine5-carboxylic acids ethyl esters
Authors: Nosova N. A. , Skrylkova A. S. , Egorov D. M.
Published: April 2024

A new series of 6-methyl-4-aryl-2-thio-1,2,3,4-tetrahydropyrimidine-5-carboxylic acids ethyl esters was synthesized. The reaction of the obtained esters with dimethyl 2-chloroethynylphosphonate leads to the selective formation of new ethyl 3-(dimethoxyphosphoryl)-5-aryl-7-methyl-5 H -thiazolo[3,2- a ]pyrimidine-6-carboxylates.
Chiral 2-oxo-1,4,2-oxazaphosphorinanes: synthesis, structure and applications (a review)
Authors: Metlushka K. E. , Zinnatullin R. G. , Nikitina K. A. , Badeeva E. K.
Published: April 2024

The review summarizes the literature data on methods for the preparation of both racemic and enantiopure 2-oxo-1,4,2-oxazaphosphorinanes - phosphorus-containing heterocyclic compounds, which are N -substituted derivatives of α-aminophosphonic/phosphinic acids. Information about the potential of their use in the synthesis of biologically active substances is also provided.
Double pseudo-polymeric complexes of [Au(S2CNR2)2][TlCl4], R2 = (CH2)5, (CH2)6: preparation, structural organization, and thermal behavior (low-temperature reduction and crystallization of gold)
Authors: Bredyuk O. A. , Loseva O. V. , Rodina T. A. , Zinchenko S. V. , Smolentsev A. I. , Ivanov A. V.
Published: April 2024

The capability of thallium(I) alkylenedithiocarbamates to bind gold(III) from solutions in 2 M HCl was studied. Double complexes of [Au{S2CN(CH2)5}2][TlCl4] and [Au{S2CN(CH2)6}2][TlCl4] were preparatively isolated as individual forms of gold(III) binding into the solid phase. In the crystalline state, the ionic structural units of the complexes are combined together due to the secondary Au···S, Tl···S and S···Cl bonds that results in complicated supramolecular architectures. Thermal behavior of compounds was studied using the simultaneous thermal analysis technique; both reduced elemental gold and thallium(I) chloride were identified as the final thermolysis products.
Synthesis and study of bismuth(III) oxalates precipitated from mineral acid solutions
Authors: Timakova E. V. , Timakova T. E. , Afonina L. I. , Bulina N. V. , Titkov A. I. , Gerasimov K. B. , Volodin V. A. , Yukhin Y. M.
Published: April 2024

Bismuth oxalates of the compositions BiOH(C2O4), Bi2(C2O4)3·6H2O, Bi2(C2O4)3·7H2O, and Bi2(C2O4)3·8H2O were obtained by precipitation from bismuth solutions in perchloric, nitric, and hydrochloric acids with addition of oxalic acid. Compound compositions were confirmed by X-ray powder diffraction and chemical analysis, IR and Raman spectroscopy, and thermogravimetry. It has been shown that in the composition of bismuth(III) oxalate hydrates Bi2(C2O4)3· х H2O bismuth cation is coordinated by the oxygen atoms of carboxyl groups of oxalate ions and water molecules in the same way, and compositions, taking into account the structural features, are described by the general formula {[Bi2(C2O4)3(H2O)4]∙( x -4)H2O} n . Conditions for the oxidative thermolysis of BiOH(C2O4) and Bi2(C2O4)3·7H2O to yield the tetragonal modification of bismuth oxide β-Bi2O3 were determined.
Alkyl, aryl and hetaryl acetylenes - highly reactive multifunctional compounds (a review)
Authors: Vasilevsky S. F , Stepanov A. A
Published: April 2024

The author’s data (2000-2022) on synthesis methods, reactivity and applied aspects of aryl- and hetarylacetylenes were summarized. The specificity of alkynylarenes (hetarenes) associated with the activation of the triple bond by acceptor groups were noted. Particular attention was paid to fundamentally important new reactions of heterocyclization and complete soft cleavage of the triple bond. The prospects for the use of alkynylarenes and -hetarenes and their modification products were reflected. The results of screening of the synthesized compounds were presented.
Chemical stability of Pb[(UO2)2O2(OH)2](H2O) and Pb2[(UO2)5O6(OH)2](H2O)2 compounds in aqueous solutions
Authors: Nipruk O. V , Klinshova K. A , Chernorukov G. N , Denisova A. A , Abrazheev R. V
Published: April 2024

The chemical stability of Pb[(UO2)2O2(OH)2](H2O) and Pb2[(UO2)5O6(OH)2](H2O)2 compounds in aqueous solutions was studied. The acid-base boundaries of the existence of these compounds in aqueous solutions were established, the hydrolysis products were identified, and the solubility was determined. Based on the data obtained, the equilibrium constants of dissolution reactions, the Gibbs functions of the formation and dissolution of Pb[(UO2)2O2(OH)2](H2O) and Pb2[(UO2)5O6(OH)2](H2O)2, were calculated, the solubility curves of the compounds under study, and the phase diagrams of U(VI) and Pb(II) in saturated aqueous solutions and in equilibrium solid phases were calculated.
Effect of glass crystallization parameters on conductivity of Li1.5+xAl0.5Ge1.5SixP3–xO12 glass-ceramics
Authors: Kuznetsova E. S , Pershina S. V , Kuznetsova T. A
Published: April 2024

Glass-ceramic samples of the Li1.5+ x Al0.5Ge1.5Si x P3- x O12 system ( x = 0-0.1) were obtained by directional crystallization of glasses. The glass transition, onset and peak temperatures of crystallization were determined using differential scanning calorimetry. The phase composition of glass-ceramics was determined by X-ray phase analysis. Electrical conductivity is studied using electrochemical impedance. Based on the data obtained, the homogeneity region of solid solutions was established and the optimal conditions for producing SiO2-doped glass-ceramics were identified. The composition with x = 0.02, crystallized at 750°C with a heating rate of 3 deg/min for 2 h, had the highest lithium-ion conductivity at room temperature (4.55×10-4 S/cm).