bluuebunny/crossref_metadata_2025 huggingface dataset:
PALM-COEIN Classification in Patients with Abnormal Uterine Bleeding
Authors: Hossain Dr. Mohammed Kamal , Akhter Dr. Shirin , Akter Dr. Parvin , Parvin Dr. Jannath , Pervin Dr. Shahana
Published: December 2022

Introduction: Abnormal uterine bleeding, (AUB) is the commonest menstrual problem during reproductive age. However, if the menstrual cycles are too short or too long, and the bleeding amount is too much, or a woman bleeds out of their normal menstrual cycle, that is classified as abnormal uterine bleeding. Abnormal uterine bleeding can have many causes. It is important to identify the type and cause of abnormal uterine bleeding among women to make proper treatment easily accessible and affordable. The FIGO classification system, otherwise known as PALM- COEIN classification system in non- gravid women, is a great method for the determination of types and causes of AUB. Aim of the Study: The aim of the study was to observe the PALM-COEIN classification among abnormal uterine bleeding cases in Bangladesh. Methods: This prospective observational study was conducted at the Department of Gynecology, Cumilla Medical College Hospital, Cumilla, Bangladesh. The study duration was 1 year, from July 2021 to June 2022. During this period, a total of 111 cases were selected following the inclusion and exclusion criteria. A purposive sampling method was used for the selection of the patients. Result: Mean age of the participants was 39.90 years, and the age range was 18-66 years in the present study. Lower abdominal pain was observed in 63.06% of abnormal bleeding cases. The average menstrual cycle length was 15-30 days for 46.85% of participants, and the age at menarche was 11-13 years for 62.16% of participants. 18.02% of the participants had been nulliparous, and 81.99% had been multiparous. Age at marriage was 15 years or lower for 11.71% of the participants, while the majority (54.95%) had been between the ages of 16-20 years. 46.85% had no associated risk factors. 36.04% had obesity, and 21.62% had hypertension. Anemia was a very common clinical finding, observed in 87.39% of cases. USG findings of the patients revealed a bulky uterus for 36.04% of cases, and fibroid was ..
Health and Nutritional Status of Women in Different Regions of West Bengal, India: A Comparative Study between NFHS-4 and NFHS-5
Authors: Ghosh Juni , Pal Biswajit
Published: December 2022

Women are the important pillar of society but they are not getting proper health care and nutrition which makes them more vulnerable. This study is based on secondary data which has been taken from National Family and Health Survey (NFHS-4, 2015-2016 & NFHS-5, 2019-2021).The study aims to understand the change in health status among women aged 15-49 years in different districts of West Bengal by comparing different health parameters (BMI, obesity, anaemia, high blood sugar and high blood pressure) between two rounds of NFHS. It has been observed that the prevalence of underweight women has decreased from the 4th round of NFHS to the 5th round whereas the rate of obesity has increased in most of the districts of West Bengal except the southern region. Increasing trends of obesity, anaemia, diabetes and hypertension among women have been revealed that make a threat to women’s health and development as well as to society. The nutritional and health status among women needs more attention and concern. The initiative should be taken to aware women of their nutrition, nutritional deficiency, health and public health care facilities.
The Relationship between Left Atrial Volume and Diastolic Dysfunction in 500 Bangladeshi Patients
Authors: Karim Md. Fazlul
Published: December 2022

Background: An increase in the left atrial volume index (LAVI) has been linked to left ventricular (LV) diastolic dysfunction (DD), a risk factor for cardiovascular events. Objective: In this study our main goal is to evaluate the relationship between Left Atrial Volume and Diastolic Dysfunction in 500 Bangladeshi Patients. Method: This cross sectional study was carried out at tertiary hospital from January 2021 to January 2022 among 500 Bangladeshi patients in whom a transthoracic echo was indicated were studied at cardiology department. The eligible patients were adults aged 20 to 86 years, who presented sinus rhythm and had no history of atrial or ventricular arrhythmia, pacemaker use, valvular disease (other than mild) or congenital cardiopathy. Forty five individuals were excluded since their exams were not adequate for analyzing mitral diastolic flow (n = 35) or LAVI (n = 10). The 500 remaining patients comprised the final sample for this study. Results: Mean age and male percentage were higher in the DD groups as compared to the normal function group left ventricular mass were higher in the DD groups as compared to the normal function group. The ejection fraction was markedly reduced only in the grade III DD group (ventricular filling restriction pattern).LAVI and dimensions progressively increased with DD grade increase: 21 ± 4.2 mL/m2, 26.1 ± 7.5mL/m2 (grade I), 33.4 ± 4.6mL/m2 (grade II), 50.4 ± 2.8mL/m2 (grade III) (p < 0.001). Plus, as expected, there was a relative decrease of the E- wave and E/A ratio, and an increase of the mitral deceleration time in the grade I DD groups (altered relaxation) in comparison to the group with normal diastolic function; the opposite was observed in the group with grade III DD (restrictive pattern). The e' wave was significantly smaller in all DD grades, in comparison to the group with preserved diastolic function. Progressive increase of the E/e' ratio was observed with worsening DD. There was a significant and ......
Efficacy of Azithromycin and Doxycycline in the Treatment of Acne Vulgaris- A Single Center Study in Bangladesh
Authors: Zaman Dr. Shaila , Sumsuzzoha Dr. S.M. , Sattar Dr. Md. Abdus , Das Dr. Arun Kumar
Published: December 2022

Background: Acne vulgaris is a very common skin disease which is seen primarily in adolescents and young adults. For cost-effectiveness and tradition, doxycycline has been used in treating acne vulgaris for a long period of time. On the other hand, it is assumed that as azithromycin poses a long half-life so it is more effective than any other antibiotic in treating acne vulgaris. But we have very little comparative data regarding this issue. Aim of the Study: The aim of this study was to compare the efficacy of azithromycin with doxycycline in treating acne vulgaris. Methods: This prospective, comparative study was conducted in Department of Skin & Venereology, Joypurhat District Hospital, Bangladesh, during the period from July 2020 to June 2021. A total of 110 patients with moderate-to-moderately severe (Grade II and III), acne vulgaris were finalized as the study population and divided into two groups. Patients of Group A were given azithromycin 500 mg three times a week as pulse therapy along with 0.05% topical tretinoin for one month and the patients of Group B were given doxycycline 100mg once daily along with 0.05% topical tretinoin for one month. Results: In this study, after 1 month of treatment, in Group A among 33(60.0%) and 22(40.0%) participants we found mild and moderate non-inflammatory lesions respectively which were found in 35(63.6%) and 20(36.4%) cases respectively in Group B and we found a significant correlation (P=0.004). Besides these, after 1 month of treatment, in Group A among 35(63.6%) and 19(34.6%) participants, we found mild and moderate inflammatory lesions respectively which were found in 33(60.0%) and 21(38.2%) cases respectively in Group B and we found a significant correlation (P=0.004) also. But at the same time, in analyzing the frequencies of ‘total lesions’ between the groups we found an extremely significant correlation where the P value was found as <0.001. Conclusion: Although, for eradicating non- inflammatory lesions, ....
Prevalence and Pattern of Dyslipidemia among Patients Attending in a Tertiary Care Hospital in Bangladesh
Authors: Parvin Dr. Roksana , Muna Dr. Farzana Zaman , Hossain Dr. Quazi Farahnaz , Sampa Dr. Sharmin Rahman , Jahan Dr. Sharmin
Published: December 2022

Background: Dyslipidemia was defined according to the third report of the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III, USA, 2001), TC level ≥200 mg/dl, HDL-C level <40 mg/dl, LDL-C level ≥130 mg/dl, TG ≥150 mg/dl. Dyslipidemia was defined as having at least one of the following: high TC, high LDL- C, low HDL-C and high TG. Dyslipidemia is considered as a major risk factor for several life-threatening diseases. Aim of the study: The aim of this study was to assess the prevalence and pattern of dyslipidemia among patients attending in a tertiary care hospital in Bangladesh. Methods: This cross-sectional analytical study was conducted at the Department of Biochemistry and Molecular Biology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh. The study duration was one year from March 2016 to February 2017. Non-probability sampling method was used in study subject selection. In total 510 patients underwent lipid profile analysis as the diagnostic procedure of several diseases was finalized as the study population. Fasting blood samples were collected from study subjects to estimate the serum TC, TG, and HDL-C. LDL cholesterol was calculated using the Friedewald equation [LDL-C= (TC—HDL-C)—(TG/5)]. Collected data was checked, edited and then processed with the help of the software Statistical Package for Social Sciences (SPSS) version 23 program. Results: In this study, among total 510 participants 245 were with dyslipidemia and the rest 265 were with normo-lipidemia. So, prevalence of dyslipidemia was found as 48% among total patients. As per the distribution of study subjects according to lipid disorder pattern we observed that, 19.4%, 15.3% and 13.3% of our dyslipidemia patients were with isolated hypercholesterolemia, isolated hypertriglyceridemia and mixed hyperlipidemia respectively. In assessing the pattern of dyslipidemia according to age in considering mean levels of isolated hypercholesterolemia, ........
Evaluate of Angiographic Severity of Coronary Artery Disease in Patients with NSTEMI by Gensini Score and Vessel Score
Authors: Haque Md. Mozammel , Ali Dr. Md. Zulfikar , Shil Dr. Tapan Chandra , Kabir Dr. Md. Humayun , Halder Dr. Debabrata , Ali Dr. Sharmin , Mamun Dr. Al , Alam Dr. Iftequar
Published: December 2022

Background: Cardiovascular disease is leading cause of mortality and morbidity in developed and developing countries. Metabolic syndrome (MS) is a risk factor for coronary artery disease (CAD). Objective: The aim of this study is to evaluate the angiographic severity of coronary artery disease in patients with NSTEMI by Gensini score and \Vessel score. Methods: This cross-sectional observational study was done at the National Institute of Cardiovascular Diseases (NICVD), Dhaka. A total of 100 patients with NSTEMI underwent coronary angiography were included in the study. Coronary angiogram was done during index hospital admission. On the basis of WHR, study patients were divided into two groups: 50 patients of NSTEMI with normal WHR (Male <0.90, Female <0.80) were assigned as group I and 50 patients of NSTEMI with increased WHR (Male ≥0.90, Female ≥0.80) were assigned as group II. Results: In this study patients with non-critical CAD (14% vs 0%, P = 0.02) and single vessel disease (58% vs 24%, P = 0.005) were more frequent in Group I, on contrary double vessel disease (24% vs 56%, P = 0.001) and triple vessel disease (4% vs 20%, P = 0.03) were more frequent in patients of Group II with significant difference. Conclusion: WHR levels were found to be higher in patients with high degree of angiographic stenosis in terms of Genseni’s score.
Efficient Callus and Shoot Induction Protocol from Leaf and Node Explants of Javanese Ginseng (Talinum paniculatum (Jacq.) Gaertn.)
Authors: Restiani Ratih , Dolonseda Anggel Christia , Kaban Sarah Mega Pratenna , Hutabarat Cindy Talenta , Sekar Astrid Ayu , Meliana Florencia Angel , Linardi Matthew , Verrell Nigel , KY Angelita Abri Berliani
Published: December 2022

This present study was carried out to determine an efficient and reproducible callus and shoot induction protocol of Talinum paniculatum by using leaf and node explants. Explants were cultured in MS medium supplemented with a combination and concentration 2,4-D and kinetin (0, 1, 2, 3 mgL-1) in single or combination treatment for 14 days. The best response of callus and shoot induction (100%) and the fastest callus (6,0 ± 2,31 days) and shoot induction (5,0 ± 1,15 days) from leaf explants were obtained from MS medium supplemented with (1 mgL-1 2,4-D and 1 mgL-1 kinetin) and (3 mgL-1 2,4-D and 1 mgL-1 kinetin) respectively. In the case of node explants, none of calli were produced, whereas the best response of shoot induction (100%) and the fastest shoot induction (4,0 ± 0 days) were obtained from MS medium supplemented with 3 mgL-1 kinetin. Callus produced from leaf explant has a bright yellow color and friable texture. The optimized protocol of callus and shoot induction for Talinum paniculatum plant could be used effectively for mass propagation to fulfill the demand of the pharmaceutical industry as well as for its cultivation.
Jugal Lipoma: A Rare Case and Review of the Literature
Authors: Berrezouk Dr. Maroua , Abir Badreddine , Lakouichmi Mohammed , Abouchadi Abdeljalil
Published: December 2022

Presentation of a documented case of a lipoma of the jugal region and data from the literature on this subject. This is a 55-year-old patient with a 10-month history of swelling in the right jugal region that was found to be a lipoma on pathological examination after surgical excision. Although lipoma is the most common benign soft tissue tumor, jugal localizations are rare. We report a new case to the scientific community to document this rarity.
Tibial Osteolipoma: A Case Report and Review of the Literature
Authors: Solaja Taiwo Olufemi , Ogunkoya John Omotola , Imishue Onome Tobore , Ladele Akindele Emmanuel
Published: December 2022

Osteolipoma is an extremely rare histologic variant of lipoma. It is sometimes called lipoma with osseous element. It can occur in any part of the body ranging from intracranial cavity to different musculoskeletal regions. We presented a case seen in a 40 years old Nigerian woman with a non-enlarging, non-tender swelling in the right leg just below the knee joint medially. The diagnosis was confirmed by histology after excisional biopsy which examination showed sheets of matured adipocytes traversed into lobules by fibro collagenous strands. Osteolipoma is still relatively rare. However, they are benign and should not be confused with other sinister lesions.
Vesical Lithiasis on an Intrauterine Contraceptive Device That Migrated Into the Bladder: About Two Cases
Authors: Benabdallah Y. Staouni , Larrache Y. , Benkerroum A. , Moataz A. , Dakir M. , Debbagh A. , Abouateib R.
Published: December 2022

The use of an Intrauterine Device (IUD) is the most economical form of contraception in the world, but it has some complications. Intra-vesical migration of IUD and the formation of stones are a rare complication. It can cause symptoms of the lower urinary tract. Imaging is crucial for diagnosis. Endourological management is the preferred option because the success rate is high with minimal morbidity. We present the management of two cases of intrauterine device migration forming an intra-vesical calculus with dysuria, suprapubic pain and hematuria.
Primary Tuberculosis of the Eye Lid – A Rare Manifestation, Case Report in a Tertiary Care Medical College & Hospital
Authors: Nibhoria Sarita , Rani Ekta , Kaur Arshdeep , Sandhu Parminder Jeet Singh , Samra Sukhmani
Published: December 2022

We present a case of cystic lobulated swelling on upper and lower lid margin in a 45 years old woman. No other local or systemic features were associated with it. An incisional biopsy was performed under local anaesthesia. The histopathological examination revealed epithelioid cell granulomas and multiple Langhans type giant cells (Tubercular).
Regression of chronic pain syndrome refractory to opioid pharmacotherapy in a patient after implantation of a spinal cord neurostimulator: case report
Authors: Burmistrova Aleksandra V. , Vorobyev Alexey N. , Varyukhina Maria D. , Ilina Anna A. , Radutnaya Margarita L. , Yakovlev Alexey A. , Grechko Andrey V.
Published: December 2022

BACKGROUND: Pain in cancer patients, often poorly treated, cause severe distress for patients and their caregivers, and significantly reduces quality of life. Modern guides for the medical treatment of chronic pain in cancer patients are not effective in all cases, especially when chronic neuropathic pain syndrome occurs. In this regard, there is a need for a multidisciplinary personalized approach to the tactics of chronic pain management in favor of surgical methods at earlier stages of this condition. Nowadays neuromodulation is widely used for the treatment of neuropathic chronic pain syndrome in patients with various pathologies, whereas it is not used routinely in cancer patients.
CLINICAL CASE DESCRIPTION: We introduce a case report of successfully applied neuromodulation in patient with severe chronic pain syndrome due to rectal cancer. Epidural spinal cord stimulation at Th10Th12 levels allowed to stop the systemic use of opioids and achieve long-term remission. Spinal cord stimulation has shown itself to be very promising and significantly improved patients quality of life.
CONCLUSIONS: Our case report evidently shows that current chronic pain management guides and treatment recommendations needs a revision and neuromodulation usage in category of cancer patients should be considered.
Assessment of rehabilitation in children with infectious diseases of the lower respiratory tract using the categories of the International Classification of Functioning, Disability and Health
Authors: Melnikova Elena V. , Ivanova Galina E. , Uskov Alexander N. , Skripchenko Natalia V. , Khasanova Nina M. , Kudryavtsev Alexander V. , Shergold Ekaterina Yu. , Lepikhina Tatyana G.
Published: December 2022

BACKGROUND: Solving the issues of rehabilitation of children after lower respiratory tract infections requires putting up rehabilitation diagnoses in the categories of the International Classification of Functioning, Disabilities and Health (ICF).
AIMS: The study aimed to define the key problems in the ICF categories and make quantitative and qualitative assessments of the changes in the ICF domains in convalescent children with infectious diseases of the lower respiratory tract at the outpatient stage and in one month after the disease.
MATERIALS AND METHODS: The assessment of rehabilitation was performed using the ICF categories for 201 convalescent children with lower respiratory tract infections.
RESULTS: Most of the patients had significant impairments in the following functions: b134 Sleep functions; b152 Emotional functions; b280 Feeling of pain; b440 Respiratory functions; b450 Additional respiratory functions; b455 Exercise tolerance function; b460 Sensations associated with cardiovascular and respiratory functions; b730 Muscle strength functions; b740 Muscular endurance functions; b780 Sensations associated with muscles and motor functions, both at the time of discharge from the hospital and a month after the discharge. Environmental factors (e115 Products and technologies for personal use in daily life; e225 Climate; e260 Air quality; e310 Close relatives; e355 Medical workers; e410 Relationships with immediate family members; e450 Relationships with medical workers; e580 Medical services; e585 Services in education and training) were shown to have an influence on rehabilitation process.
CONCLUSION: The identified range of functioning disorders and the influence of environmental factors indicates the need for medical rehabilitation for convalescent children with lower respiratory tract infections. The rehabilitation should be multidisciplinary and involve psychological and pedagogical techniques, work with the family, and motor rehabilitation techniques to restore workload tolerance.
ANTIOXIDANT ACTIVITY LEAVES OF MENGKUDU (Morinda Citrifolia L.) SKIN EXTRACT IN SERUM PREPARATION WITH DPPH METHOD
Authors: Maulina Syarifah Nadia , Sari Nurmala , Hamsi Fadhillah
Published: December 2022

The leaves of mengkudu is a native plant from Indonesia that contains flavonoid compounds that have antioxidant activity so that is beneficial for the skin. This research was conducted using the escperimental method and used test materials  for ethanol extract of the leaves of the subdued by the maceration method, formulated into serum preparations in various concentrations, namely 3%, 4%, 5% and blanks, and physical quality examination of the preparations. The results of the ph test showed a ph 6,3-6,5. Serum bath results at an F3 concentration (5%) which is the preferred (best) preparation. The results of the 6% moisture content test, the results of obtaining 10,3% leaf extract. It has antioxidant activity including the (strong) category with an IC50 value of 50.40. Testing the antioxidant activity of the ethanol extract of the leaves of mengkudu (morinda citrifolia L.) belongs to the category (very strong) with an IC50 value 44.27 μg / mL, the antioxidant activity of the blanks of serum preparations including the category (inactive) with an IC50 value of 676.49 μg / mL, and all serums of this purifying leaf extract do not cause irritation to the skin.
FAKTOR YANG MEMENGARUHI KEIKUTSERTAAN IBU YANG MEMILIKI ANAK UMUR 9 BULAN SAMPAI 5 TAHUN UNTUK IMUNISASI MR (MEASLES DAN RUBELLA) DI WILAYAH KERJA PUSKESMAS PB SELAYANG II KOTA MEDAN
Authors: Putri Sri Yuni Windu , Marianti Endang , Lumbanraja Sarma N
Published: December 2022

Imunisasi adalah suatu tindakan pencegahan dini yang harus dilakukan agar anak-anak terhindar dari berbagai penyakit, salah satunya yaitu campak/rubella yang sangat berbahaya apa bila menyerang anak - anak. Imunisasi juga dapat meningkatkan imunitas anak sehingga anak tidak mudah sakit. Tujuan penelitian untuk mengetahui faktor yang memengaruhi keikutsertaan ibu yang  memiliki anak umur 9 bulan sampai 5 tahun untuk              imunisasi MR (Measles dan Rubella) di Wilayah Kerja Puskesmas PB Selayang II Kota Medan. Desain penelitian menggunakan metode kuantitatif yang dilakukan survei analitik dengan pendekatan Cross Sectional Study. Populasi dalam penelitian ini adalah seluruh balita sebanyak 6.685 orang. Sampel menggunakan sistem Cluster Random Sampling sebanyak 99 orang balita. Analisis data menggunakan analisis univariat, bivariat dan multivariat. Hasil penelitian menunjukkan bahwa ada hubungan pengetahuan, sikap, kepercayaan, dukungan keluarga, dukungan tenaga kesehatan dan media informasi terhadap keikutsertaan ibu yang memiliki anak umur 9 bulan sampai 5 tahun untuk imunisasi MR (Measles dan Rubella) di Wilayah Kerja Puskesmas PB Selayang II Kota Medan. Sedangkan faktor yang paling dominan yaitu dukungan keluaraga p = 0,000 < 0,05 dan 95% CI = 5.389-316.539 dengan OR=41.154. Kesimpulan dari penelitian ini adalah ada pengaruh pengetahuan, sikap, kepercayaan, dukungan keluarga, dukungan tenaga kesehatan dan media informasi terhadap keikutsertaan ibu yang  memiliki anak umur 9 bulan sampai 5 tahun untuk imunisasi MR (Measles dan Rubella) di Wilayah Kerja Puskesmas PB Selayang II Kota Medan. Disarankan kepada pihak Puskesmas PB Selayang II dalam memberikan informasi berupa penyuluhan kepada masyarakat terutama kepada ibu yang memiliki anak untuk meningkatkan cakupan pemberian imunisasi Measles dan Rubella (MR), agar pengetahuan ibu menjadi baik, sikap menjadi positif, dan mendapatkan dukungan dari keluarga untuk memberikan imunisasi Measles, Rubella (MR).
AI Based Parkinson Disorder Diagnosis System – A Comprehensive Review
Authors: C. D. Anisha  , N. Arulanand
Published: December 2022

Parkinson Disorder (PD) is a progressive neurological disorder. There is no specific and quantitative based PD diagnosis system. Artificial Intelligence (AI) is a tremendously growing technology, which aids in all sectors of healthcare. AI based PD diagnosis provides quantitative assessment more than subjective assessment, thereby providing robustness in diagnosis. This paper presents the review of Artificial Intelligence (AI) based PD diagnosis system. The conceptual framework for AI based PD diagnosis system, the challenges and future prospects in the domain of AI in PD diagnosis have been discussed.
Analisis Usaha Benih Lele Sangkuriang (Clarias Garipinus) Pada Unit Pengembangan Budidaya Air Tawar Dinas Perikanan Kabupaten Tulungagung
Authors: Pratama Yoga , Kurnianto Bambang Tri , Faisal Herry Nur
Published: December 2022

Ikan lele sangkuriang ikan yang banyak diminati masyarakat di Kabupaten Tulungagung. Tujuan Penelitian ini untuk mengetahui berapa pendapatan dan kelayakan pembenihan ikan lele sangkuriang. Dalam pengambilan sampel yang digunakan yaitu purposive. Hasil penelitian menujukan bahwa UPT PBAT Dinas Perikanan Tulungagung melakukan pembenihan ikan lele sangkuriang dengan 2 sistem yaitu sistem alami dan sistem buatan. Dari kedua sistem pembenihan menujukkan pendapatan yang paling tinggi adalah pembenihan sistem alami dengan memperoleh Rp. 2.000.000, pada sistem buatan memperoleh Rp. 1.725,00 dalam satu kali pembenihan, dan kelayakan usaha (BCR) pembenihan  ini memperoleh B/C 2,5 pada sistem alami dan 2,2 pada sistem buatan. Dari kedua sistem pembenihan yang paling menguntungkan    yaitu dengan sistem buatan karena jumlah telur dan larva lebih banyak     dibandingan dengan sistem alami karena pada saat penelitian jumlah indukan lebih banyak pada pemijahan secara alami. Kesimpulan dari kedua metode tersebut dengan sistem alami dan buatan masih layak untuk dilanjutkan dan dikembangkan.
Determinan Faktor Motivasi Kerja Pembuat Ikan Kering Di Kota Bengkulu
Authors: Winati Sara Enggal , Priyono Basuki Sigit , Yuristia Rahmi
Published: December 2022

Penelitian ini bertujuan untuk menganalisis tingkat motivasi kerja pada pembuat ikan kering di kota Bengkulu, dan menganalisis faktor-faktor penentu motivasi kerjanya. Pemilihan lokasi dilakukan secara sengaja. Sampel penelitian berjumlah 47 orang yang dipilih menggunakan metode simple random sampling. Hasil penelitian ini menunjukkan bahwa tingkat motivasi kerja pembuat ikan kering di kota Bengkulu adalah sebanyak 25 orang atau 53% mempunyai motivasi kerja yang tinggi. Akan tetapi hasil uji korelasi dan pengujian hipotesis bahwa faktor tingkat pendidikan dan persepsi terhadap usaha merupakan faktor yang memiliki hubungan dengan motivasi kerja pada pembuat ikan kering di Kota Bengkulu. Sedangkan faktor umur, jumlah anggota keluarga, pendapatan periode sebelumnya, persepsi terhadap bahan baku dan persepsi terhadap pemasaran merupakan faktor yang tidak memiliki hubungan dengan motivasi kerja pada pembuat ikan kering di Kota Bengkulu.
LES DEUX VALEURS PRISES AUJOURD’HUI PAR LES FÊTES TRADITIONNELLES DANS DEUX LOCALITÉS CORÉENNES
Authors: Kim Kyuwon
Published: December 2022

Dans la société coréenne traditionnelle, le shamanisme des classes populaires s’opposait au confucianisme des classes supérieures. Les fêtes en témoignaient, qui s’ouvraient par d’austères rituels confucéens, avant de connaître la liesse d’inspiration shamanique qui les avaient seules dominées avant le début de la dynastie de Chosun (1392-1910). Avec la modernisation et l’urbanisation du pays, les fêtes ont évolué. A la périphérie de Séoul, il ne subsiste de la fête que sa composante confucéenne et le repas commun qui la suit. Au sud du pays, dans une île, la composante populaire et shamanique est demeurée vivante. Dans les deux cas, la dimension sacrée de la fête s’est adaptée aux aspirations des populations actuelles : besoin de sérénité et convivialité dans les environnements suburbains ; affirmation de la permanence du groupe dans l’île.
Specificity of the condition of the skin barrier in patients with congenital epidermolysis bullosa as a factor of transcutaneous sensitization by food allergens
Authors: Galimova Albina A. , Makarova Svetlana G. , Murashkin Nikolay N.
Published: December 2022

Congenital epidermolysis bullosa is a heterogeneous group of hereditary dermatoses resulting from a pathogenic variant of the genome-encoding proteins of the dermo-epidermal junction. Epidermolysis bullosa is mainly manifested as the formation of blisters and erosions on the skin and mucous membranes in response to minor mechanical action. Itching is one of the most common symptoms of epidermolysis bullosa, reduces the quality of life, and causes additional skin damage.
The influence of comorbid pathology, which can increase itching, is not excluded. Skin inflammation secondary to a disruption in the skin barrier, wound-healing cascades, and unregulated activation of epidermal sensitive nerve endings are involved in the pathophysiology of itching at the molecular and cellular levels. Diffuse damage to the skin and mucous membranes, leading to the loss of their barrier properties, contributes to the excessive intake of antigens, including allergens of food and non-food origin, and to transcutaneous sensitization. However, food sensitization and food allergy in these patients have not been sufficiently studied. Understanding the causes of these processes may be crucial for the development of optimized techniques for managing children with congenital epidermolysis bullosa and improvement of their quality of life.
This review summarizes updated data on clinical and genetic aspects of congenital epidermolysis bullosa.
THE DEPTH AND BREADTH OF TEACHING ENGLISH: BASIS FOR A MODIFIED MODULE
Authors: Jessa Joy Pimentel Andarza
Published: December 2022

With the introduction of K–12 curricula that incorporate literature as a springboard, teaching and learning English has become a prerequisite. Language is used in context throughout literature. According to Eaglestone (2010), it is a crucial component of the English curriculum in schools and needs to receive the sufficient emphasis if the overall goal of teaching English is to be accomplished. Teachers now have a duty to work more to make studying English for pupils a simpler, more pleasurable, and more rewarding experience.
Anglo-American literature is covered in English 9, which is regarded as a crucial conventional course in English. According to Lu Rui (2014), the rapid development of curricula in the modern era has caused English literature to face a variety of challenges and flaws, pushing the current liberal arts class even further into the margins. As a result, the reform of the curriculum for Anglo-American literature cannot be postponed in the modern era.
Wu Ling (2012) emphasized that another significant challenge teachers have while teaching students in English literature, including grammar and vocabulary, is the multifaceted competencies that must be attained. The perception that literature is a challenging and tedious topic compounds to this challenge. Students gradually disassociate from the subject matter as a result of this.
In the national setting, Calacal (2003) stated that education in the Philippines has always been dynamic. Everything that has been dynamic certainly echoes possible problems. In the K to 12 curriculum, the Department of Education requires learning modules to be used in learning the subjects, specifically in English. Hence, whether the use of this learning package gush on, the crux of the issue lies in the learner and teacher as they move on towards the development of English competencies. In some of the challenges experienced by both teachers and learners are broad module content, lack of comprehension of students, taking English subject difficult, and the lengthy literature pieces used. In dealing with English language and literature, Hernandez (2003) said that teaching and learning strategies should be updated to make lessons comprehensible for students.
Therefore, it is worthwhile investigating these difficulties, identifying their causes, and suggesting effective remedies for these problems so that they will not damage the benefits that Grade 9 English embodies.
HUBUNGAN INDEKS MASSA TUBUH DAN USIA MENARCHE DENGAN KEJADIAN DISMENOREA PADA REMAJA PUTRI
Authors: Mandasari Pera
Published: December 2022

Latar Belakang: Dismenore adalah keluhan sewaktu haid dalam siklus teratur akibat dari peningkatan kadar prostaglandin dalam darah haid. Usia menarche yang lebih awal merupakan faktor risiko yang berpengaruh terhadap kejadian dismenorea. Tujuan: Untuk mengetahui hubungan indeks massa tubuh dan usia menarche dengan kejadian dismenorea pada remaja putri. Metode: Penelitian bersifat analitik, dengan pendekatan cross sectional. Populasi penelitian ini adalah siswi SMK Kesehatan Pelita Insani tahun 2020 berjumlah 345, dan sampel yang diambil sebanyak 185 orang berdasarkan rumus solvin. Instrumen penelitian berupa kuesioner. Data dianalisis secara univariat dan bivariat menggunakan uji chi square. Hasil: Terdapat 145 responden (78,4%) yang tidak mengalami dismenorea, 153 responden (82,7%) memiliki indeks massa tubuh, dan 152 responden (82,2%) yang memiliki usia menarche normal. Ada hubungan yang bermakna antara indeks massa tubuh dengan kejadian dismenorea dengan nilai p 0,000 < α 0,05 dan ada hubungan yang bermakna antara usia menarche dengan kejadian dismenorea dengan nilai p 0,000 < 0,05. Saran: Disarankan bagi dinas kesehatan untuk dapat meningkatkan penyuluhan ke sekolah terutama tentang dismenore sehingga pengetahuan remaja menjadi meningkat dan paham tentang dismenore.    Kata Kunci: Dismenorea, Indeks Massa Tubuh, Usia Menarche
PENGARUH PEMBERIAN SEDUHAN AIR BAWANG PUTIH TERHADAP TEKANAN DARAH PADA PASIEN HIPERTENSI
Authors: Zuhana Zuhana , Pahrul Dedi , Sepriyanti Efta
Published: December 2022

Latar Belakang: Hipertensi atau sering disebut tekanan darah tinggi merupakan salah satu masalah global dunia. Pengobatan hipertensi dapat dilakukan dengan dua cara yakni dengan cara farmakologis dan non farmakologi (herbal) seperti bawang putih. Bawang putih mengandung senyawa-kimia, beberapa senyawa tersebut memiliki efek farmakologi, yaitu efek pencegahan, perawatan, dan pengobatan penyakit untuk mencegah darah tinggi bagi orang dengan tekanan darah normal. Tujuan: Diketahuinya pengaruh pemberian seduhan air bawang putih terhadap tekanan darah. Metode: Desain penelitian yang digunakan adalah pre experimental dengan pendekatan one group pretest-posttest. Penelitian dilaksanakan di wilayah Kerja Puskesmas Pegayut Kecamatan Pemulutan, waktu pengumpulan data penelitian dilakukan pada tanggal 14 sampai dengan 19 Juni 2021. Populasi dalam penelitian ini adalah penderita hipertensi, dari bulan Januari-31 Mei 2021 sebanyak 645 penderita diwilayah kerja Puskesmas Pegayut Kecamatan Pemulutan. Sampel penelitian ini sebanyak 30 penderita hipertensi dengan tehnik pengambilan sampel menggunakan purposive sampling dan teknik analisis menggunakan uji t-test paired. Hasil: Hasil uji statistik didapatkan sistolik 126,93 dan diastolik 112,53 sebelum pemberian, sistolik 125,43 diastolik 88,90 sesudah pemberian, nilai sistolik p sistolik sebelum dan sistolik sesudah 0,006 (p<0,05), nilai p diastolik sebelum dan diastolik sesudah 0,00 (p<0,05). Yang menunjukan bahwa ada pengaruh perbedaan sebelum dan sesudah pemberian seduhan air bawang putih terhadap penurunan tekanan darah pasien diwilayah Kerja Puskesmas Pegayut Kecamatan Pemulutan tahun 2021. Saran: Untuk meningkatkan pelayanan edukasi kesehatan pada penderita hipertensi yang berkaitan dengan obat herbal atau tanaman herbal yang dapat menurunkan tekanan darah seperti memperbanyak leapflat, brosur atau mading yang berhubungan dengan pengobatan hipertensi menggunakan bawang putih. Kata Kunci: Bawang putih, Tekanan darah, Hipertensi
HUBUNGAN LAMA MEROKOK DAN FREKUENSI MEROKOK DENGAN KADAR HEMOGLOBIN (Hb) PADA PEROKOK AKTIF
Authors: Septiani Rima
Published: December 2022

Latar Belakang: Lama merokok dan frekuensi merokok dapat memberikan efek akut maupun kronis, salah satunya pada fungsi dalam darah yaitu dapat menurunkan kadar hemoglobin. Tujuan: Mengetahui bagaimanakah hubungan frekuensi merokok dengan kadar hemoglobin pada perokok aktif di lingkungan Kelurahan X Kota Palembang. Metode: Penelitian ini merupakan penelitian deskriptif kuantitatif. Waktu penelitian dilaksanakan bulan Mei- Juni tahun 2021.Populasi pada penelitian ini yaitu 45 orang. Sampel yang berjumlah 31 orang dengan menggunakan kuesioner, Hb meter digital. Teknik analisis data menggunakan uji statistik korelasi Rank Spearman. Hasil: Gambaran kadar hemoglobin menunjukkan bahwa sebesar (48,4%) responden penelitian dengan kadar Hb normal yang artinya sebagian besar responden dalam penelitian ini memiliki kadar Hb yang tidak normal yaitu (51,6%). Sebagian besar usia dewasa (29%),  lansia (71%), lama merokok < 10 tahun (22,6%), lama merokok ≥ 10 tahun (77,4%), perokok ringan (41,9%), perokok sedang (35,5%), dan perokok berat 22,6%). Hasil analisis didapatkan ada hubungan yang bermakna antara lama merokok dengan kadar hemoglobin (p=0,024, r=403) dan ada hubungan yang bermakna antara frekuensi merokok dengan kadar hemoglobin (p=0,005, r=0,487). Semakin banyak frekuensi merokok dan lama merokok maka kadar hemoglobin semakin rendah. Saran : Dengan bertambahnya pengetahuan dampak merokok terutama komponen dalam darah, maka pada perokok diharapkan dapat mengurangi dalam mengkonsumsi rokok. Kata Kunci: Hemoglobin, Frekuensi Merokok, Lama Merokok
KARATERISTIK KUNJUNGAN KEHAMILAN KEEMPAT PADA IBU YANG MEMILIKI ANAK 0-18 BULAN
Authors: Agustia Nency , Haryanti Ita
Published: December 2022

Latar Belakang: Cakupan kujungan kehamilan keempat (K4) di Kabupaten Ogan Komering Ulu (OKU) tahun 2020 sebesar 87,5% menurun pada tahun 2019 sebesar 0,6% dengan target kabupaten sebesar 100%. Tujuan: Untuk mengetahui hubungan karateristik Kunjungan Kehamilan  (K4) pada ibu yang memiliki anak usia 0-18 bulan di OKU tahun 2022. Metode: Penelitian Kuantitatif dengan desain cross sectional. Tempat penelitian di Kabupaten OKU pada bulan Februari 2022. Populasi penelitian yaitu ibu yang memiliki anak usia 0-18 di bulan februari 2022 dengan pengambilan sampel menggunakan multistage random sampling didapatkan sebanyak 84 orang yang memenuhi kriteria inklusi. Analisa univariat dan bivariat menggunakan chi-sqaure dan multivariat menggunakan  logistik berganda. Hasil: Ada hubungan paritas (p-value = 0,003), pekerjaan (p-value = 0,000) dan informasi kunjungan kehamilan (p-value = 0,000) dan tidak ada hubungan usia (p-value = 0,735) , status pendidikan (p-value = 0,806) , kepemilikan kartu jaminan Kesehatan (p-value = 1,000), komplikasi kehamilan (p-value = 0,009) dan perencanaan kehamilan (p-value = 0,804) dan variabel yang paling dominan adalah paritas (p-value =0,002), status pendidikan (p-value = 0,005), pekerjaan (0,015) dan informasi kunjungan (p-value= 0,998) dengan kunjungan kehamilan keempat di wilayah kerja Kabupaten OKU tahun 2022. Saran : Diharapkan petugas Kesehatan di wilayah OKU memberikan penyuluhan terkait pentingnya jadwal kunjungan kehamilan, pemeriksaan kehamilan gratis di fasilitas kesehatan dan petugas kesehatan yang memiliki wewenang untuk melakukan pemeriksaan kehamilan di praktek mandirinya mau melakukan klaim ke badan jaminan kesehatan dibandingkan memilih ibu membayar pemeriksaan kunjungan kehamilannya.  Kata Kunci: Ibu Hamil, K4, Karateristik
PECULIARITIES OF THE HUMAN MAXILLA MORPHOGENESIS
Authors: Tsyhykalo Oleksandr V. , Kuzniak Nataliia B. , Dmytrenko Roman R. , Perebyjnis Pavlo P. , Bernik Nataliia V. , Krynychnykh Hanna I. , Honcharenko Valentyna A.
Published: December 2022

The aim: To find out the sources of formation and the chronological sequence of the morphogenesis of the maxilla at the early stages of human ontogenesis.
Materials and methods: 14 series of consecutive histological specimens of human embryos and prefetuses (4,0-66,0 mm of parietal-coccygeal length) aged from 4 to 11 weeks of intrauterine development with the use of a complex of modern morphological methods of investigation (anthropometry, morphometry, microscopy, and 3D computer reconstruction) were studied.
Results: On the basis of a complex of morphological research methods, data were obtained that made it possible to establish the general patterns of development of the human maxilla: separation of the pharyngeal apparatus (4th week), convergence and fusion of the jaw processes (5-8th weeks), formation of tooth buds (7-8th weeks), which allows considering the specified periods as critical in the formation of possible anomalies in the facial part of the skull. At the same time, a tendency of heterochrony of morphological transformations in the maxilla and maxilla was revealed.
Conclusions: 1. At the beginning of the 4th week of intrauterine development, 3 pairs of pharyngeal arches are formed. Detachment of the mandibular and maxillary processes of the mandibular pharyngeal arch is planned. 2. During the 7th week of intrauterine development, the maximum convergence of the maxillary processes with the lateral and medial nasals occurs, and in embryos of 20.0 mm PCL grow with the frontal process, forming the maxilla and upper lip. During the 8th week of intrauterine development, the bone base of the jaws is modeled as a result of the increase in the size of osteogenic islands and their fusion, alveolar processes are formed. 3. During the 9-10th weeks of intrauterine development, the primary palate is formed as a result of the fusion of the palatine processes. 4. At the 11th week of intrauterine development, the bone base models both jaws. Due to the processes of histogenesis of the soft tissues of the maxillofacial apparatus, the face acquires anthropomorphic definitive human features.
THE ANALYSIS OF THE IMPACT OF THE TYPE OF CONTRACEPTION USED BY WOMEN ON THE LEVEL OF THEIR SEXUAL SATISFACTION AND COMFORT OF USE
Authors: Romaniuk Bartłomiej
Published: December 2022

The aim: To compare satisfaction of women using oral contraception to satisfaction of women using the levonorgestrel-secreting intrauterine system. In the comparison the following factors were taken into account: comfort of use, menstrual cycle, libido level, well-being and the impact on the relationship with a partner.
Materials and methods: The study involved 129 randomly selected women who had to fill in the research survey questionnaire.
Results: It has been proved that patients are more willing to use the intrauterine system secreting levonorgestrel because of a more reliable contraceptive effect and convenience of use. This kind of contraception has a beneficial effect on libido and relationships with a partner. Women using oral contraception did not report such advantageous influence of their method of contraception. An increase in libido was noticed for 24 women in the group of patients using the levonorgestrel-secreting intrauterine system and for 8 women in the group of users of oral contraception, which corresponds to 33.8% and 13.8%. Patients used oral contraception more often in order to regulate their menstrual cycle and to reduce heavy menstrual bleeding.
Conclusions: The study identifies groups of women for whom a specific method of contraception would be appropriate. The greatest benefits of using the levonorgestrel-secreting intrauterine system will have patients who appreciate the convenience of use, as well as those who have sex drive disorders or for whom oral contraception causes undesirable symptoms. Women with hormonal disorders, irregular menstrual cycles and heavy menstrual bleeding will benefit most from the use of oral contraception.
DYNAMICS OF FIBROTIC CHANGES IN THE LIVER AFTER THE SUCCESSFUL ERADICATION OF HEPATITIS C VIRUS IN PATIENTS WITH NAFLD
Authors: Derbak Mariya A. , Lizanets Nataliya V. , Hanych Oksana T. , Horlenko Olesya M. , Mashura Hanna Y. , Boiko Serhii O. , Rozumyková Nad’a
Published: December 2022

The aim: To assess the dynamics of serum levels of angiopoietin-2 and transforming growth factor-β1 in patients with chronic hepatitis C (CHC) with concomitant nonalcoholic fatty liver disease (NAFLD) after successful DAAs.
Materials and methods: 82 patients with CHC were examined, of which 56 were diagnosed with NAFLD and increased body weight. Ang-2, TGF-β1, leptin, adiponectin, and the degree of liver fibrosis were determined for all participants. The patients were divided into groups: 1 gr. (n=23) – CHС + increased body weight + hepatic steatosis, 2 gr. (n=33) – СНС + increased body weight + nonalcoholic steatohepatitis, 3rd gr. (n=26) – CHC. All patients received DAAs for 12 weeks.
Results: From 82 patients F3-4 had 31 people, F1-2 – 25, F0-1 – 11, F0 -15 patients. F3-4 and steatosis S2-3 (p<0.05) was more common in patients of 2 gr.. Serum Ang-2 levels were higher (p<0.05) in patients of 2 gr. with F3-4, than in patients with F0-2. Fibrosis regression occurred more often in patients with 1 and 3 gr. with F1-2 than in patients 2 gr. and F3-4 and was accompanied by a decrease in Ang-2 and TGF-β1 levels.
Conclusions: High levels of Ang-2 and TGF-β1 are registered in patients with CHC+NAFLD, which correlate with the degree of liver fibrosis and significantly decrease after successful DAAs in patients with low initial stages of liver fibrosis and normal body weight.
THE CLINICAL EXPERIENCE OF THE EFFECTIVE USE OF DAPAGLIFLOZIN IN COMORBID CARDIAC PATIENTS WITH CONCOMITANT TYPE 2 DIABETES MELLITUS AND ARTERIAL HYPERTENSION ON THE BACKGROUND OF OVERWEIGHT IN OUTPATIENT SETTING
Authors: Rishko Oleksandr A. , Derbak Mariya A. , Ihnatko Yaroslav Y. , Dankanych Yevheniia Е. , Bletskan Myroslava M. , Krasnova Anatolija A. , Mashura Hanna Y.
Published: December 2022

The aim: To assess the efficacy and safety of dapagliflozin in the treatment of comorbid cardiac patients with type 2 diabetes mellitus (T2DM) in combination with arterial hypertension (AH) and overweight in outpatient setting.
Materials and methods: Under observation were 19 patients who were treated in outpatient setting during 2019-2021 for AH and had T2DM, overweight or obesity. As part of complex treatment, patients received dapagliflozin 10 mg once a day for 12 months.
Results: The normalization of blood pressure, elimination of heart failure symptoms on the background of increased ejection fraction, improved indicators of the functional capacity of the kidneys, and a decrease in the degree of proteinuria/albuminuria were noted after treatment. The patients had an easier time losing weight (body mass index and waist circumference decreased; p<0.05) and decreased levels of total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C). None of the monitored patients had cases of hypoglycemia or urinary tract infection. The number and/or doses of antihypertensive, hypouricemic and diuretic drugs were gradually reduced.
Conclusions: Using dapagliflozin in a standard dose of 10 mg/day in the complex therapy of patients with T2DM in combination with arterial hypertension and overweight contributes not only to the normalization of blood pressure, but also to a reduction in body weight and waist circumference. The proposed therapy can be an alternative for the treatment of patients with T2DM with concomitant overweight or obesity, arterial hypertension, with or without heart and/or renal failure as a first-line antidiabetic drug.