bluuebunny/crossref_metadata_2025 huggingface dataset:
A framework of physically interactive parameter estimation based on active environmental groping for safe disaster response work
Authors: Kamezaki Mitsuhiro , Uehara Yusuke , Azuma Kohga , Sugano Shigeki
Published: October 2021

Disaster response robots are expected to perform complicated tasks such as traveling over unstable terrain, climbing slippery steps, and removing heavy debris. To complete such tasks safely, the robots must obtain not only visual-perceptual information (VPI) such as surface shape but also the haptic-perceptual information (HPI) such as surface friction of objects in the environments. VPI can be obtained from laser sensors and cameras. In contrast, HPI can be basically obtained from only the results of physical interaction with the environments, e.g., reaction force and deformation. However, current robots do not have a function to estimate the HPI. In this study, we propose a framework to estimate such physically interactive parameters (PIPs), including hardness, friction, and weight, which are vital parameters for safe robot-environment interaction. For effective estimation, we define the ground (GGM) and object groping modes (OGM). The endpoint of the robot arm, which has a force sensor, actively touches, pushes, rubs, and lifts objects in the environment with a hybrid position/force control, and three kinds of PIPs are estimated from the measured reaction force and displacement of the arm endpoint. The robot finally judges the accident risk based on estimated PIPs, e.g., safe, attentional, or dangerous. We prepared environments that had the same surface shape but different hardness, friction, and weight. The experimental results indicated that the proposed framework could estimate PIPs adequately and was useful to judge the risk and safely plan tasks.
A 24 month follow-up of refractory macular holes treated with an autologous transplantation of internal limiting membrane versus retina expansion technique
Authors: Alezzandrini Arturo , Dorrego Camila I. , Cibrán María Victoria , Cortina-Revelli Valentina , Rocco Franco D. , Zas Marcelo , Wu Lihteh
Published: October 2021

Background

To compare the functional and anatomic outcomes at 24 months of eyes with a primary macular hole that failed to close after a prior surgery and were treated with either an autologous transplantation of internal limiting membrane (AT-ILM) or the retina expansion (RE) technique.

Methods

Retrospective, single center, comparative study of 28 eyes with a macular hole that failed to close after a prior vitrectomy. All eyes had a size of ≥ 500 μm. Participants were divided into two groups according to the type of intervention performed: AT-ILM group (n = 14) and RE group (n = 14). Main outcomes measured were the MH closure rate assessed by spectral-domain optical coherence tomography (SD-OCT) and the best-corrected visual acuity (BCVA) at 24 months after surgery.

Results

Patients in the AT-ILM group experienced a statistically significantly improved post-operative BCVA (median 49.50 letters, range 20–66 letters) over the pre-operative BCVA (median 39 letters, range 18–52 letters) (p-value = 0.006 Wilcoxon paired sample test). In contrast, patients in the RE group did not achieve a statistically significant improvement (p-value = 0.328, Wilcoxon paired sample test). The median pre-operative BCVA was 35 letters (range 18–52 letters), whereas the median post-operative BCVA was 39 letters (range 16–66 letters). At 24 months of follow-up, 85.7% of patients in the AT-ILM group achieved closure compared to 57.1% in the RE group (p-value = 0.209, Fisher’s exact test). Multivariate analysis showed that MH size and baseline BCVA were important determinants of post-operative BCVA. The baseline MH size was the only significant pre-operative factor that influenced MH closure.

Conclusions

This study demonstrates similar closure rates for both groups however better visual outcomes were obtained with the AT-ILM.
Treatment-resistant venous thrombosis and pulmonary embolism in a patient with granulomatosis with polyangiitis: a case report
Authors: Wakuda Chiharu , Aoki Yoshitaka , Sugimura Sho , Katsuragawa Takayuki , Obata Yukako , Mimuro Soichiro , Doi Matsuyuki , Nakajima Yoshiki
Published: October 2021

Background

We herein present a case of venous thrombosis that developed more than 20 years after diagnosis of granulomatosis with polyangiitis (GPA), although many reports of GPA have described venous thrombosis within 1 year of diagnosis.

Case presentation

A 73-year-old man with GPA was admitted for lower extremity swelling and diagnosed with venous thrombosis and pulmonary embolism. On the second day, catheter-based thrombolysis was unsuccessful, and inferior vena cava filter insertion and anticoagulation were performed. On the third day, respiratory disturbance and loss of consciousness appeared and progressed. The patient died on the fifth day. The autopsy revealed a large thrombus in the inferior vena cava filter, and death of progressive venous thrombosis was suspected.

Conclusions

We experienced a case of venous thrombosis that developed 20 years after diagnosis of GPA, although GPA is frequently associated with venous thrombosis immediately after diagnosis. The thrombosis progressed rapidly and was resistant to treatment.
Distribution and habitat use of the endangered Siberian flying squirrel Pteromys volans (Rodentia: Sciuridae)
Authors: Lim Sang Jin , Kim Ki Yoon , Kim Eui Kyeong , Han Chang Wook , Park Yung Chul
Published: October 2021

Background

Understanding the habitat characteristics of the endangered Siberian flying squirrelPteromys volansis the first step in conserving and managing the forests it requires for nesting, gliding, and feeding. Therefore, in the present study, we characterized the habitats ofP. volansusing GIS analysis of 411 forest sites in South Korea where fecal droppings were found.

Results

Fecal signs ofP. volanswere found in various regions in South Korea, including the Baekdudaegan Mountains. GIS analysis with six environmental layers (vegetation type, wood-age class, diameter at breast height [DBH], crown density, elevation, and distance from stream) revealed that fecal signs ofP. volanswere more frequently found in broad-leaved deciduous forests (42%) located 200–399 m above sea level (43.1%) and 0–199 m from the nearest stream (53%), with 5th class wood-age (35.3%), middle size class DBH (51.1%), and high crown density (71%).

Conclusions

The present study provides information on the biotic and abiotic characteristics ofP. volanshabitats. In South Korea, the fecal droppings ofP. volanswere found predominantly old deciduous broadleaf forests. Further studies are needed to reveal whether the more frequent occurrence ofP. volansdropping in broadleaf forests may be due to a particular preference of this species for the forests or to a simple reflection of the area of the broadleaf forests occupying a much larger area than other forest types in Korea.
Potential of the entomopathogenic fungus, Metarhizium anisopliae s.l. in controlling live-wood eating termite, Microtermes obesi (Holmgren) (Blattodea: Termitidae) infesting tea crop
Authors: Deka Bhabesh , Babu Azariah , Peter Arulmarianathan John , Kumhar Kishor Chand , Sarkar Suman , Rajbongshi Hirakjyoti , Dey Pritam , Amalraj Emmanuel Leo Daniel , Talluri Venkateswara Rao
Published: October 2021

Background

In recent years, Microtermes obesi (Holmgren) (Blattodea: Termitidae) has been recorded as a major pest of tea crop, causes significant losses in production. Managing termite pests in tea crops through an integrated approach has been suggested, and the use of microbial biocontrol agent is one of the economical methods. The present study evaluated the pathogenic efficacy of an entomopathogenic fungus Metarhizium anisopliae s.l. (= M. anisopliae) against M. obesi damaging tea plants under field conditions.

Results

Metarhizium anisopliae s.l. was formulated as 5% aqueous suspension (AS).
Large-scale field trials with formulated entomopathogen revealed that 1000 and 1200 ml concentrations of M. anisopliae s.l. 5%AS (each concentration containing 2 × 107 conidia/ml) each in 400 l of water/ha significantly (P < 0.05) reduced the population of M. obesi in tea gardens at Dooars and Darjeeling regions, India. In the field study, M. anisopliae s.l. was more effective than the standard insecticide and was non-pathogenic on the beneficial insects present in the tea gardens. In addition, M. anisopliae s.l. 5%AS had no phytotoxic effect on the tea leaves, with acceptable organoleptic attributes.

Conclusion

Metarhizium anisopliae s.l. isolate can be commercialized as an alternative natural termiticide to reduce the load of synthetic insecticides in the tea crop.
How COVID-19 pandemic changed our management strategies for amyotrophic lateral sclerosis (ALS) patients: Egyptian study
Authors: Rashed Hebatallah R.
Published: October 2021

Background

There are several studies that have discussed the efficacy of telemedicine with amyotrophic lateral sclerosis (ALS) patients; however, this approach is still preliminary in Egypt and in North Africa. The objective of the current study is to discuss current experience with telemedicine in monitoring patients in the specialized ALS clinic in Egypt. Efficacy of Revised Amyotrophic Lateral Sclerosis Functional Rating Scale (ALSFRS-R) in monitoring disease progression remotely will be discussed.

Results

This is a prospective study. Forty-three ALS patients were included in this study in the period between July 1, 2020, and February 6, 2021. Fifty-three telemedicine encounters and 13 post-telemedicine office visits were available. None of the participating patients had COVID-19 infection. Eight patients showed decline in ALSFRS score. ALSFRS-R score reported during telemedicine encounters was confirmed during office visits. Three bulbar onset ALS patients had gastrostomy, and 2 bulbar onset ALS patients had Botox injection for drooling. All eight patients with declining ALSFRS-R were maintained on non-invasive ventilation (NIV) based on their symptoms.

Conclusion

This is the first study discussing telemedicine in the field of ALS in Egypt and North Africa. ALSFRS-R showed feasibility and reliability in detecting disease progression remotely.
Data-driven nonlinear constitutive relations for rarefied flow computations
Authors: Zhao Wenwen , Jiang Lijian , Yao Shaobo , Chen Weifang
Published: October 2021

To overcome the defects of traditional rarefied numerical methods such as the Direct Simulation Monte Carlo (DSMC) method and unified Boltzmann equation schemes and extend the covering range of macroscopic equations in high Knudsen number flows, data-driven nonlinear constitutive relations (DNCR) are proposed first through the machine learning method. Based on the training data from both Navier-Stokes (NS) solver and unified gas kinetic scheme (UGKS) solver, the map between responses of stress tensors and heat flux and feature vectors is established after the training phase. Through the obtained off-line training model, new test cases excluded from training data set could be predicated rapidly and accurately by solving conventional equations with modified stress tensor and heat flux. Finally, conventional one-dimensional shock wave cases and two-dimensional hypersonic flows around a blunt circular cylinder are presented to assess the capability of the developed method through various comparisons between DNCR, NS, UGKS, DSMC and experimental results. The improvement of the predictive capability of the coarse-graining model could make the DNCR method to be an effective tool in the rarefied gas community, especially for hypersonic engineering applications.
Does dehydration prior to primary total joint arthroplasty increase risk of perioperative complications?
Authors: Moore Harold G. , Justen Marissa A. , Kirwin David S. , Burroughs Patrick J. , Rubin Lee E. , Grauer Jonathan N.
Published: October 2021

Background

Prior studies have suggested that preoperative dehydration increases odds of perioperative complications in several areas of orthopedic surgery. This study aimed to evaluate whether preoperative hydration status is associated with the incidence of short-term complications after primary total joint arthroplasty.

Methods

The 2012–2019 National Surgical Quality Improvement Program (NSQIP) database was used to explore the relationship between preoperative dehydration (ratio of preoperative BUN divided by preoperative Creatinine (BUN/Creatinine) > 20) and perioperative outcomes of total hip (THA) and total knee arthroplasty (TKA) patients. Univariate comparisons and multivariate regression analyses were conducted to identify specific complications that occurred more often in patients with preoperative dehydration.

Results

Of 188,629 THA and 332,485 TKA patients, 46.3 and 47.0% had preoperative dehydration, respectively. After controlling for demographics and comorbidities, dehydrated THA patients were no more likely to experience a complication compared to their non-dehydrated counterparts (relative risk [RR] = 0.97, 99.7% Confidence Interval [CI]: 0.92–1.03, P = 0.138) nor increased risk of blood transfusion (RR = 1.02, CI = 0.96–1.08, P = 0.408). Similar to THA patients, dehydrated TKA patients were not more likely to have a complication after surgery (RR = 0.97, CI = 0.92–1.03, P = 0.138) and were at no greater risk of transfusion (RR = 1.02, CI = 0.96–1.07, P = 0.408). A sub-analysis covering only patients with BUN and Cr values determined within 24 h after surgery was performed and similarly found no significant increase in perioperative complications or transfusion.

Conclusion

Overall, preoperative dehydration in patients undergoing THA/TKA did not appear to increase risk of transfusion or other perioperative complications. Further research is needed to characterize the role of hydration prior to elective total joint arthroplasty.
Development and evaluation of the refined zenith tropospheric delay (ZTD) models
Authors: Yang Fei , Meng Xiaolin , Guo Jiming , Yuan Debao , Chen Ming
Published: October 2021

The tropospheric delay is a significant error source in Global Navigation Satellite System (GNSS) positioning and navigation. It is usually projected into zenith direction by using a mapping function. It is particularly important to establish a model that can provide stable and accurate Zenith Tropospheric Delay (ZTD). Because of the regional accuracy difference and poor stability of the traditional ZTD models, this paper proposed two methods to refine the Hopfield and Saastamoinen ZTD models. One is by adding annual and semi-annual periodic terms and the other is based on Back-Propagation Artificial Neutral Network (BP-ANN). Using 5-year data from 2011 to 2015 collected at 67 GNSS reference stations in China and its surrounding regions, the four refined models were constructed. The tropospheric products at these GNSS stations were derived from the site-wise Vienna Mapping Function 1 (VMP1). The spatial analysis, temporal analysis, and residual distribution analysis for all the six models were conducted using the data from 2016 to 2017. The results show that the refined models can effectively improve the accuracy compared with the traditional models. For the Hopfield model, the improvement for the Root Mean Square Error (RMSE) and bias reached 24.5/49.7 and 34.0/52.8 mm, respectively. These values became 8.8/26.7 and 14.7/28.8 mm when the Saastamoinen model was refined using the two methods. This exploration is conducive to GNSS navigation and positioning and GNSS meteorology by providing more accurate tropospheric prior information.
Study of white matter integrity in fathers of children with attention deficit hyperactivity disorder
Authors: ElShahawi Heba H. , Effat Safeya M. , Shorab Eman M. , Sakr Hossam M. , Azab Safaa E. , Aufa Ola M.
Published: October 2021

Background

Attention deficit hyperactivity disorder (ADHD) is an early-onset neurodevelopmental disorder that can extend into adulthood with multiple reported neuroimaging abnormalities. The focus of this research was to assess white matter impairments in ADHD children’s fathers with and without potential adult ADHD to see if these differences are connected with the persistence of ADHD into adulthood.

Results

The occurrence rate of the potential adult ADHD diagnosis among fathers of children with ADHD was 60%. There were statistically significant differences between fathers with ADHD and the non-ADHD population, due to the fact that the mean FA of the left superior corona radiata and the right posterior corona radiata were lower in the ADHD group than in the non-ADHD group, while the FA of the ADHD group was significantly greater than that of the non-ADHD group in terms of the left and right anterior thalamic radiations, the right superior longitudinal fasciculus and the left anterior corona radiata.

Conclusions

We observed an increased prevalence of ADHD in fathers of children diagnosed with ADHD. Fathers with potential adult ADHD have a variety of white matter abnormalities that reflect the neurobiological basis of ADHD, even in sub-threshold cases. This may provide insight into the neuroanatomical locations associated with the maintenance of ADHD throughout adulthood.
Erythema marginatum: an uncommon presentation of acute rheumatic fever in a Nigerian adolescent girl—a case report
Authors: Animasahun Barakat Adeola , Lawani Faith O. , Lamina Moriam Omolola
Published: October 2021

Background

Erythema marginatum is an uncommon presentation in children with acute rheumatic fever and it is one of the major criteria needed to make a diagnosis. It is seen in less than 10% of cases. It is also reported to be difficult to detect in black-skinned children. This is the first and only patient to present with the above since the inception of the unit about 14 years ago and also the first to be reported in Nigeria as far as the authors are aware, after a careful literature search; hence, we report this case based on the rarity of this symptom of acute rheumatic fever.

Case presentation

This is a case report of O.E, a 12-year-old Nigerian girl who presented with features of acute rheumatic fever, and these features included the rare manifestation of erythema marginatum. She presented with generalized skin eruptions on the trunk and extremities, sparing the face, migratory polyarthritis, features of congestive heart failure and high grade continuous fever. The skin lesions consisted of papules, patches, plaques and polycycles with a reticular pattern having serpiginous and raised borders. Diagnostic investigations revealed elevated erythrocyte sedimentation rate of 83mm/h, anti-streptolysin O titer of 2020IU/L and echocardiography which showed thickened mitral valves with grade II mitral regurgitation and a mild pulmonary artery hypertension. The patient was treated with anti-inflammatory and anti-failure drugs and commenced secondary prophylaxis with benzathine penicillin. Skin eruptions resolved within 3 weeks of management and are currently on follow up.

Conclusions

We present the above to increase awareness on the possibility of acute rheumatic fever presenting with erythema marginatum in our region, to encourage early diagnosis of acute rheumatic fever to reduce morbidity and mortality from its sequel, rheumatic heart disease.
Restricted diffusion MRI as a functional biomarker for the assessment of acute calcular upper urinary tract obstruction: initial experience
Authors: El Atta Heba M. Abou , Sakrana Amal Abdelsattar , Shebel Haytham
Published: October 2021

Background

Acute renal obstruction due to stone is a prevalent scenario. The diffusion-weighted magnetic resonance imaging (DWI) of the kidneys provides a noninvasive information on renal function. Our objective is to prospectively assess the potential role of DWI to predict the signal changes of a kidney with acute calcular obstruction.

Results

Chi-square and Fissure exact tests were used to assess the association of diffusion signal changes among patients and control groups. Cohen's Kappa test was run to determine the degree of agreement between the two radiologists. An independent sample t-test was performed to assess the significant difference among ADC values between the two groups. Restricted signals of the obstructed kidneys showed a statistically significant difference when compared with contralateral unobstructed kidney and control group with p value (0.001) and (0.01), respectively. Furthermore, there is a moderate agreement between the two radiologists K = 0.7, p = 0. 001. There is no statistically significant difference in ADC values when comparing the obstructed kidney and the contralateral unobstructed kidney of the patient group or with the control group p value (0.06) and (0.05), respectively.

Conclusion

Restricted signals of the obstructed kidney by DWI may be a helpful tool in diagnosing acute unilateral renal obstruction and can affect its management; however, it needs further validation by more studies.
Insights on the left ventricular thrombus in patients with ischemic dilated cardiomyopathy
Authors: Mehana Elsayed M. , Shawky Abeer M. , Abdelrahman Heba S.
Published: October 2021

Background

Left ventricular thrombus (LVT) formation represents a common complication of dilated cardiomyopathy (DCM). LVT is usually underestimated with transthoracic echocardiography (TTE) while cardiac magnetic resonance imaging (CMRI) is promising as an alternative imaging modality for cardiac thrombus detection. The study aims to compare TTE and CMRI in their ability to detect LVT, also, to assess the clinical and imaging parameters to determine variables that may predispose for thrombus formation. The study population includes seventy-six patients with ischemic DCM. They were divided into 2 groups based on the presence of LVT as detected by delayed-enhancement CMRI (DE-CMRI) [Group A included 20 patients with a LVT and Group B included 56 patients without].

Results

All of the current study population had ischemic DCM with left ventricular ejection fraction (LVEF) < 50%. DE-CMR detected thrombus in 20 cases of the studied population that represented group A. From group A, conventional TTE detected LVT only in 8 and cine-CMR detected 13 cases out of the out of 20 cases. The ejection fraction of the left ventricle as measured by functional CMRI was significantly lower in group A (P = 0.045). Interestingly, the myocardial scarring in group A was seen significantly more extensive than in group B (the P value is < 0.00001), paralleling the increased prevalence of thrombus.

Conclusions

DE-CMRI provides superiority for the detection of LVT compared with standard TTE or cine-CMRI and the amount of myocardial scarring detected by DE-CMRI can be considered an independent marker for thrombus presence.
Characterization and In-silico toxicity prediction of degradation products of felbamate
Authors: Chodankar Rahul S. , Mahajan Anand A.
Published: October 2021

Background

The objective of the work carried out was to assess the toxicity of the degradation products (DPs) for the drug felbamate. Stress studies were performed in the condition specified in the international council of harmonization (ICH) guideline Q1A (R2).

Results

The drug degraded under the alkaline stress conditions to generate two degradation products (DPs). They were separated on a Phenomenex C8 column (250 mm × 4.6 mm, 5 µm); mobile phase composition was 10 mM ammonium formate (pH adjusted to 3.7 with formic acid) and acetonitrile (80:20, v/v); flow rate and wavelength for recording absorbance were 1.0 ml/min and 206 nm, respectively. The structures of the degradation products were characterized by LC–MS/MS analysis.

Conclusion

The drug was prone to hydrolysis in the presence of alkali. It was found to be stable under other stress conditions, viz., acidic, neutral, thermal, photolytic and oxidative. The structures of the impurities were characterized by LC–MS/MS. The drug and the DPs were screened through ADME and toxicity prediction software’s like pkCSM, Toxtree and OSIRIS property explorer. Felbamate was flagged for possible hepatotoxicity.
Extension of the kinematic approximations to the multilayered elastic orthorhombic medium
Authors: Xu Shibo , Stovas Alexey
Published: October 2021

Understanding the kinematics of horizontally layered reservoir rocks is important to their proper characterization; to accomplish this, it is necessary to specify the explicit model for these kinematic properties. Accurate approximations for traveltime and relative geometric spreading in an elastic homogeneous orthorhombic (ORT) model have been investigated with different forms: shifted hyperbola form (SHF), Taylor series, and the rational form. We have extended these approximations to the multilayered ORT model by adopting composite coefficients and effective model parameters. The multilayered model is characterized without and with the azimuthal variation among layers. There is an overdetermined problem when the azimuthal variation exists; to address that case, the least-squares method is adopted. To check the feasibility of the expansion, we select the SHF approximation specified in the homogeneous elastic ORT model for the calculation in the numerical example. Four groups of examples are analyzed to investigate the influence on the accuracy of the approximation with the change in rotation angle, degree of anisotropy, and the direction of the orientation. The results indicate that, for the multilayer, the accuracy of the approximation is proportional to the degree of anisotropy and the value of the angle of rotation. The relative errors in traveltime and relative geometric spreading in this multilayered extension are very small and can be implemented in practical applications.
Estimating the parameters of simple models from two-component on-time airborne electromagnetic data
Authors: Bagley Thomas , Smith Richard S.
Published: October 2021

The horizontal and vertical components of an on-time electromagnetic (EM) response can be used to estimate the parameters of simple models such as thin sheets, half-spaces, thin sheets over a lower half-space, and a two-layer model. The formulas used in these methods are valid in areas where the on-time response is essentially proportional to the conductivity or conductance, the so-called “resistive limit.” The half-space and thin sheet over lower half-space models can be combined to give an estimate of the conductivity for a lower half-space below a thick sheet that might be reasonable for the entire survey area. With this estimation, an equation solver can be used to estimate the thickness and conductivity of the overlying thick sheet over the whole survey area. This latter approach seemed most appropriate for the Russell South area in the Athabasca Basin, Canada, where GEOTEM data have been collected. The output of the algorithm was generally stable. Although it did not always reliably reproduce the overburden thicknesses as measured in a set of reference drillholes, it did give an estimate that was reasonable in the relatively conductive areas.
Geomorphologic evolution of the northern Tibetan Plateau in the Quaternary: Tectonic and climatic controls
Authors: Liu Weijing , Liu Keyu , Liu Jianliang , Zhang Yifan
Published: October 2021

Situated in the northwestern Qinghai-Tibet Plateau, the Qaidam Basin is the largest Cenozoic terrestrial intermountain (enclosed) basin in the world. It is an ideal place for understanding the coupling control of tectonics and climate on sedimentary evolution. Numerous studies on the Quaternary sedimentary evolution of the Qaidam Basin have been done, most of which are local, conceptual, and qualitative in nature. We have investigated the entire Qaidam Basin and its surrounding mountains quantitatively as a single entity to probe the Quaternary evolution of the basin-range system in the northern Qinghai-Tibet Plateau. We used a basin and landscape dynamics ( Badlands) modeling algorithm that is capable of modeling landscape evolution by simulating erosion, sediment transport, and deposition in a source-to-sink context by considering climate changes and tectonic uplift/subsidence. We have simulated the evolution of the Qaidam Basin and its surrounding mountains since 2.5 Ma quantitatively. Tectonic uplift and climate changes appear to have a direct impact on the denudation and deposition rates, but the impact varies through time. The deposition in the Qaidam Basin was mainly affected by tectonic movement during the period of 2.5–0.6 Ma, reaching a maximum deposition thickness of 2130 m at the end of 0.6 Ma, which was prevailed by climate after 0.6 Ma during the last four glacial-interglacial periods, reaching a maximum deposition thickness of 3200 m. The Qilian Mountains and the Kunlun Mountains contributed the bulk sediments to the Qaidam Basin of approximately 35% and 40%, respectively. The Altun Mountains made a significant contribution to the sediments in the Qaidam Basin during the early period of the Quaternary from 2.5 to 2.4 Ma due to a high denudation rate. The findings provide new insights for analyzing geomorphic and landscape evolution as well as source-to-sink systems in the Northern Qinghai-Tibet Plateau or elsewhere.
Visualizing hydrocarbon migration pathways associated with the Ringhorne oil field, Norway: An integrated approach
Authors: Connolly David , Lakhlifi Assia , Rimaila Kristoffer , Kocsis Gabor , Fæstø Ingrid , Yarushina Viktoriya , Wang Hongliang
Published: October 2021

Norway’s Ringhorne Field is a faulted anticline, which produces oil from Triassic (Statfjord) and Paleocene (Hermod) sands. It is located on the Utsira High. Geochemical studies of the produced oil indicate that the oil is generated from mature Upper Jurassic marine shales in the adjacent Viking Graben. However, it is not clear how oil migrated into the Triassic reservoirs and charged the overlying Paleocene reservoirs. Lateral hydrocarbon migration is not detectable on seismic data. However, vertical hydrocarbon migration can be observed as a vertically aligned, low-amplitude, chaotic signature on normally processed seismic data. Gas-chimney detection is a proven neural network technique to detect these vertical hydrocarbon migration pathways. The processing results are then validated using a set of criteria to determine if they represented true hydrocarbon migration rather than seismic artifacts. The chimney processing results using this traditional (shallow) neural network are compared with convolutional neural network (deep learning) results and geomechanical modeling on key lines. Key reservoirs are delineated using a deterministic simultaneous seismic inversion approach. Reliable chimneys are then visualized in the vicinity of the producing reservoirs. The results indicate pathways by which the Triassic fluvial sands received the charge and how these reservoirs have flank leakage to provide the charge to shallower Paleocene reservoirs. This approach is currently being used over hundreds of fields and dry holes in the Norwegian North Sea and worldwide as analogs to assess the hydrocarbon charge and top seal risk predrill.
Bioanalytical Challenges due to Prior Checkpoint Inhibitor Exposure: Interference and Mitigation in Drug Concentration and Immunogenicity Assays
Authors: Dengler Andrew F. , Weiss Rachel , Truong Tiffany , Irvin Susan C. , Gadhia Nidhi , Hassanein Mohamed , Georgaros Camille , Taylor Jessica-Ann , Paccaly Anne , Sumner Giane , Andisik Matthew D. , Torri Albert , Partridge Michael A.
Published: October 2021

Monoclonal antibodies (mAbs) are a leading class of biotherapeutics. In oncology, patients often fail on early lines of biologic therapy to a specific target. Some patients may then enroll in a new clinical trial with a mAb specific for the same target. Therefore, immunoassays designed to quantify the current mAb therapy or assess immunogenicity to the drug may be susceptible to cross-reactivity or interference with residual prior biologics. The impact of two approved anti-PD-1 mAbs, pembrolizumab and nivolumab, was tested in several immunoassays for cemiplimab, another approved anti-PD-1 mAb. The methods included a target-capture drug concentration assay, a bridging anti-drug antibody (ADA) assay and a competitive ligand-binding neutralizing antibody (NAb) assay. We also tested bioanalytical strategies to mitigate cross-reactivity or interference in these assays from other anti-PD-1 biologics. Both pembrolizumab and nivolumab cross-reacted in the cemiplimab drug concentration assay. This was mitigated by addition of antibodies specific to pembrolizumab or nivolumab. ADA specific for pembrolizumab and nivolumab did not interfere in the cemiplimab ADA assay. However, pembrolizumab and nivolumab generated a false-positive response in a target-capture NAb assay. Our results demonstrate that similar exogenous pre-existing anti-PD-1 mAbs (biotherapeutics) such as pembrolizumab and nivolumab are detected and accurately quantified in the cemiplimab drug concentration assay. However, once steady state is achieved for the new therapy, prior biologics would likely not be detected. Cross-reactivity and interference in immunoassays from previous treatment with class-specific biotherapeutic(s) pose significant bioanalytical challenges, especially in immuno-oncology.

Graphical abstract
Prolactin mediates behavioural rejection responses to avian brood parasitism
Authors: Ruiz-Raya Francisco , Ibáñez-Álamo Juan Diego , Parenteau Charline , Chastel Olivier , Soler Manuel
Published: October 2021

Adaptations resulting from co-evolutionary interactions between avian brood parasites and their hosts have been extensively studied, yet the physiological mechanisms underlying antiparasitic host defences remain little known. Prolactin, one of the main hormones involved in the regulation of avian parental behaviour, might play a key role in the orchestration of the host responses to avian brood parasitism. Given the positive association between prolactin and parental behaviour during incubation, decreasing prolactin levels are expected to facilitate egg-rejection decisions. We tested this prediction by implanting Eurasian blackbird (Turdus merula) females with an inhibitor of prolactin secretion, bromocriptine mesylate, to experimentally decrease their plasma prolactin levels. Bromocriptine mesylate-implanted individuals ejected mimetic model eggs at higher rates, and showed shorter latency to egg ejection, than placebo-treated birds. To our knowledge, this is the first experimental evidence that behavioural host defences against avian brood parasitism are mediated by prolactin.
Is maternal thyroid hormone deposition subject to a trade-off between self and egg because of iodine? An experimental study in rock pigeon
Authors: Sarraude Tom , Hsu Bin-Yan , Ruuskanen Suvi , Groothuis Ton
Published: October 2021

Maternal hormones constitute a key signalling pathway for mothers to shape offspring phenotype and fitness. Thyroid hormones (THs; triiodothyronine, T3; and thyroxine, T4) are metabolic hormones known to play crucial roles in embryonic development and survival in all vertebrates. During early developmental stages, embryos exclusively rely on exposure to maternal THs, and maternal hypothyroidism can cause severe embryonic maldevelopment. The TH molecule includes iodine, an element that cannot be synthesised by the organism. Therefore, TH production may become costly when environmental iodine availability is low. This may yield a trade-off for breeding females between allocating the hormones to self or to their eggs, potentially to the extent that it even influences the number of laid eggs. In this study, we investigated whether low dietary iodine may limit TH production and transfer to the eggs in a captive population of rock pigeons (Columba livia). We provided breeding females with an iodine-restricted (I−) diet or iodine-supplemented (I+) diet and measured the resulting circulating and yolk iodine and TH concentrations and the number of eggs laid. Our iodine-restricted diet successfully decreased both circulating and yolk iodine concentrations compared with the supplemented diet, but not circulating or yolk THs. This indicates that mothers may not be able to independently regulate hormone exposure for self and their embryos. However, egg production was clearly reduced in the I− group, with fewer females laying eggs. This result shows that restricted availability of iodine does induce a cost in terms of egg production. Whether females reduced egg production to preserve THs for themselves or to prevent embryos from exposure to low iodine and/or THs is as yet unclear.
Pricing Strategy and Pricing Determinant Factors in Sharing Logistics
Authors:   School of Business and Management, Institut Teknologi Bandung, Indonesia, Farmaciawaty Desy Anisya , Prasetyo Ahmad Danu , Larasati Niken , Inggis Raka Achmad , Putri Novialita Ayu C. Wibowo , Mulyono Nur Budi
Published: October 2021

Abstract. There is a significant change in our current business practices where the change leads the mainstream business practice into a new concept: Sharing Economy. In this research, the sharing economy will be narrowed down to a specific topic called sharing logistics. This research aims: (1) to identify the determinants that are perceived as a priority by customers in logistics service, (2) to explore the pricing method suitable for sharing logistic companies based on priority determinants, which are previously identified. To arrive at the objectives of the research, many works of literature were reviewed related to the matter of determinants and pricing strategies in the logistics service industry and related to the concept of sharing economy. Primary data was also collected through an interview with the expert of the leading logistic service company in Indonesia. In addition, the analytical hierarchy process (AHP) was conducted as well to find the proportion that represents determinants’ priority based on the perspective of the customers of logistic service providers and academic researchers. Hopefully, by identifying the determinants that are perceived as a priority by customers in logistics service, and with its appropriate pricing method, companies that run their business in logistics sharing will have a proper pricing method guideline in the first place. Keywords: Sharing economy, sharing logistics, pricing method, determinants of logistics service, analytical hierarchy process
Can Instagram convince information to users?
Authors:   Faculty of Economy, Universitas Hayam Wuruk Perbanas, Surabaya, Ilham Romi , Siregar Cantika Sari
Published: October 2021

Abstract. In the age of social media, everyone can provide opinions via electronic word of mouth (eWOM). This experiment explores how users adopt culinary information on social media, especially Instagram, as one social media platform that has many users in Indonesia. With the many opinions that develop on social media, a phenomenon appears where users must sort out the information of choosing food products. The main objective of this study was to investigate the effect of source credibility and information quality on information adoption mediated attitudes towards information and information usefulness with the object of research on food products — analysis of the research model using partial least squares on 368 valid questionnaires distributed in East Java-Bali. The literature review and analytical techniques show that the source's credibility and the quality of information positively affect the adoption of information mediated attitudes towards information and the usefulness of the information. The novelty of research on the development of information adoption models is the complex source credibility variables, including expertise, trustworthiness, attractiveness, and homophily. It is an electronic persuasion that culinary business people need in the current era of social media. Keywords: E-wom, source credibility, information adoption, instagram, culinary.
ТЕНДЕНЦИИ И РИСКИ ЦИФРОВИЗАЦИИ ВЫСШЕГО И ПРОФЕССИОНАЛЬНОГО ОБРАЗОВАНИЯ
Authors: Balganova Elena V.
Published: October 2021

Введение. В статье ставится проблема наличия скрытых негативных тенденций в ходе перехода к цифровому высшему и профессиональному образованию и влияние данных тенденций на участников образовательного процесса. Любой инновационный процесс, в том числе и образовательный, обязательно сопровождают определённые риски, которые необходимо учитывать при планировании мероприятий, особенно таких важных как цифровизация образования. Степень их влияния на возможность достижения поставленных целей может быть критичной. Мы постарались рассмотреть в статье основные риски, наиболее типичные как для органов государственной власти, так и для образовательных организаций.

Методология и методика исследования. В основе анализа последних событий, связанных с цифровизацией отечественного образования и взглядов научного сообщества на происходящие в этой области процессы нами использовались институциональный и синергетический подходы, а также метод педагогического прогнозирования. Данное исследование направлено на выявление, определение и описание возможных рисков цифровизации высшего и профессионального образования. Автор обращается к теме важности учёта данных рисков при подготовке и в ходе проведения мероприятий по цифровизации образовательного процесса.

Результаты исследования. В рамках рассмотрения отдельных тенденций цифровизации высшего и профессионального образования в нашей стране автором определены и описаны возможные риски, при игнорировании которых на этапе подготовки мероприятий, с большой долей вероятности, могут быть запущены негативные процессы, нивелирующие результаты образовательных реформ. Автор обращает внимание на обеспокоенность, высказываемую научно-педагогическим сообществом, вследствие отсутствия всесторонних исследований последствий цифровых новаций, внедряемых государством, образовательными и коммерческими организациями в сфере образования. В работе определяются основные подходы к организации деятельности по предупреждению и снижению последствий указанных рисков.

Заключение. Представленное исследование возможных негативных тенденций в процессе цифровизации образовательного процесса отмечает крайнюю важность научного подхода к проведению мероприятий в рамках цифровой реформы образования, а также напоминает о необходимости проявления активной позиции научно-педагогическим сообществом в рамках нивелирования вероятных рисков, сопутствующих данному процессу.

Область применения результатов: система высшего и профессионального образования.
ПОВЫШЕНИЕ КВАЛИФИКАЦИИ ПЕДАГОГИЧЕСКИХ РАБОТНИКОВ ВЫСШИХ УЧЕБНЫХ ЗАВЕДЕНИЙ В КОНТЕКСТЕ ФЕДЕРАЛЬНОГО ПРОЕКТА «НОВЫЕ ВОЗМОЖНОСТИ ДЛЯ КАЖДОГО»
Authors: Medvedeva Galina G. , Mitina Galina V.
Published: October 2021

Цель. В рамках реализации федерального проекта «Новые возможности для каждого» национального проекта «Образование» многие образовательные организации страны, реализующие программы дополнительного образования, предложили целый спектр программ для совершенствования или формирования новых компетенций работникам из разных отраслей экономики. В статье рассматриваются мероприятия по дополнительному профессиональному образованию педагогических работников высшего образования. В качестве цели авторы обозначают развитие концепции непрерывного образования педагогических работников высших учебных заведений на основе анализа современных потребностей рынка труда.
Метод или методология проведения работы. Основу исследования составили методы изучения нормативных документов, анализа и обобщения психолого-педагогической литературы, организации образовательного процесса.
Результаты. Результаты исследования представлены в виде опыта реализации современных программ дополнительного профессионального образования педагогических работников вузов с приобретением профессиональных компетенций в области управления развитием и инновациями в образовательных организациях; внедрения и эффективного применения современных прикладных методик преподавания; реализации программ инклюзивного образования, а также создания доступной среды.
Область применения результатов. Результаты исследования могут быть применены при реализации концепции непрерывного образования в высших учебных заведениях.
ЯЗЫКОВОЙ БАРЬЕР КАК РЕЗУЛЬТАТ РУМИНАЦИЙ В УСЛОВИЯХ ДИСТАНЦИОННОГО ОБУЧЕНИЯ
Authors: Shmalko Yulia V. , Rudakova Olga A.
Published: October 2021

Статья посвящена актуальной в условиях современной образовательной реальности теме руминаций, как следствию дистанционного обучения. Предметом анализа выступают языковой барьер у студентов лингвистических специальностей. Автор ставит целью определить негативные последствия дистанционного обучения при изучении языка.
Цель. Теоретическое обоснования феномена руминации, как языкового барьера студентов лингвистов в условиях дистанционного обучения.
Метод или методология проведения работы. Основу исследования образуют методы анализа и обобщения имеющихся в научной литературе данных, к эмпирическим методам исследования относится – анкетирование.
Результаты. Результаты работы заключаются в том, что автор исследует современные образовательные аберрации, проблематика которых заключается во влиянии на качество изучения лингвистических специальностей.
Автор делает предположение, что руминативное поведение, являясь результатом дистанционного обучения, приводит к языковому барьеру.
Область применения результатов. Результаты исследования могут быть применены в сфере социально-психологического контекста образования в условиях дистанционного обучения.
ВЗАИМОСВЯЗЬ ВРЕМЕННО́Й КОМПЕТЕНТНОСТИ И СТРЕССОУСТОЙЧИВОСТИ УЧИТЕЛЕЙ С РАЗНЫМ СТАЖЕМ РАБОТЫ
Authors: Kulikova Tatyana I.
Published: October 2021

Цель. Статья посвящена исследованию взаимосвязи между временно́й компетентностью и стрессоустойчивостью современного учителя. Актуальность исследования определяется тем, что профессиональная деятельность учителя является одной из самых интенсивных, включенных в группу профессий с большим количеством стрессовых факторов. Проблему исследования составляет противоречие между требованием к эмоциональной устойчивости учителя в процессе работы с детьми, коллегами и родителями, и отсутствием временно́й компетентности, что зачастую создает стрессовые ситуации и постоянное напряжение.
Метод. В исследовании приняли участие 67 женщин-учителей общеобразовательных школы города Тулы. Средний стаж работы учителей составил 15,64±8,7 лет, а медианный стаж 17 лет. Критерием деления учителей на две равные части было медианное значение стажа: 1-я группа со стажем работы <= 17 лет и 2-я группа со стажем работы 18 и более лет. В качестве диагностического материала были применены методика диагностика состояния стресса (А.О. Прохоров); тест самооценки стрессоустойчивости С. Коухена и Г. Виллиансона; методика «Персональная компетентность во времени»; тест-опросник самоорганизации деятельности (Е.Ю. Мандрикова). Статистическая обработка данных проводилась в программе SPSS Statistics 27 (IBM). Для установления тесноты связи между исследуемыми параметрами применялся коэффициент корреляции Пирсона. Для снижения размерности исходного пространства признаков и выявления главных факторов применялся метод главных компонент.
Результаты. Корреляционный анализ выявил наличие положительной связи между исследуемыми следующими показателями: компетентности во времени; планомерности; целеустремленности; самоорганизации; стрессоустойчивости.
Область применения результатов. Материалы исследования могут быть использованы в работе психологической службы образовательной организации и способствовать оптимизации рабочего времени учителей, повышению эффективности педагогической деятельности, а также служить основой для разработки программ дополнительного образования и повышения квалификации по основам тайм-менеджмента.
Improving Shingles Vaccination Rates in Family Medicine
Authors: Luther
Published: October 2021

At the end of the activity, participants will be able to:
• Characterize the burden of herpes zoster infections.
• Recommend the recombinant zoster vaccine to patients in accordance with guidance from the Advisory Committee on Immunization Practices.
• Implement strategies to increase patient acceptance of herpes zoster and other vaccinations.
• Use available resources to increase awareness among patients about the importance and safety of recommended vaccinations.