bluuebunny/crossref_metadata_2025 huggingface dataset:
Charged With a Crime: The Neuronal Signature of Processing Negatively Evaluated Faces Under Different Attentional Conditions
Authors: Schindler Sebastian , Bruchmann Maximilian , Krasowski Claudia , Moeck Robert , Straube Thomas
Published: July 2021

Our brains rapidly respond to human faces and can differentiate between many identities, retrieving rich semantic emotional-knowledge information. Studies provide a mixed picture of how such information affects event-related potentials (ERPs). We systematically examined the effect of feature-based attention on ERP modulations to briefly presented faces of individuals associated with a crime. The tasks required participants ( N = 40 adults) to discriminate the orientation of lines overlaid onto the face, the age of the face, or emotional information associated with the face. Negative faces amplified the N170 ERP component during all tasks, whereas the early posterior negativity (EPN) and late positive potential (LPP) components were increased only when the emotional information was attended to. These findings suggest that during early configural analyses (N170), evaluative information potentiates face processing regardless of feature-based attention. During intermediate, only partially resource-dependent, processing stages (EPN) and late stages of elaborate stimulus processing (LPP), attention to the acquired emotional information is necessary for amplified processing of negatively evaluated faces.
Effects of number of inlet guide vanes on the aerodynamic performance of a centrifugal compressor
Authors: Anbarsooz M , Amiri M , Erfanian A , Benini E
Published: July 2021

Variable inlet guide vanes (VIGVs) are widely used for flow throttling and also extending the operating range of centrifugal compressors. Although there are several studies on the effects of adding IGVs on the performance curve of the compressors, none of them have focused on the number of vanes. In the current study, high-fidelity three-dimensional numerical simulations are carried out to analyze the effects of adding VIGVs with different number of vanes on the aerodynamic performance of a single-stage centrifugal compressor. The selected compressor prototype is a high flowrate single-stage compressor equipped with a vaned diffuser, designed and fabricated by Siemens. Computational fluid dynamic simulations are performed for three different number of guide vanes at three IGV inclination angles of 0, −30 and +45 degrees. The numerical results are validated by comparing the pressure-rise curves with the available experimental data of the compressor data sheet, where a good agreement was achieved. Results show that at the fully-open condition, the number of vanes does not have considerable effect on the performance curve of the compressor. However, as the IGV inclination angle increases, the number of inlet vanes plays a considerable role in the compressor efficiency. For example, at IGV inclination angle of +45 degree, increasing the number of vanes from 7 to 11 can increase the compressor maximum efficiency up to 5 points. Numerical results showed that increasing the number of inlet guide vanes imposes a higher pressure drop in the inlet passage of the compressor while generating a more uniform velocity distribution at the suction surface of the impeller. Due to the existence of several counteracting effects, an optimum number of inlet guide vanes can be found.
Adaptive observer-based attack location and defense strategy in smart grid
Authors: Wang Wenting , Ma Qiang , Lin Lin , Guan Ti , Tian Dawei , Li Shuqi , Li Jian
Published: July 2021

This article mainly focuses on the attack location and defense of cyber-physical power systems under dynamic load altering attacks. Taking the smart grid as an example, first, the cyber-physical power system model under attack is established to provide conditions for attack detection. On this basis, an adaptive observer with [Formula: see text] performance is designed to realize detection and location through residual signal and attack estimation, respectively. Furthermore, a power redistribution strategy based on optimal economic scheduling is presented to realize attack defense by means of the observer data. Finally, theoretical analysis proves the feasibility of the algorithm, and simulation cases prove the effectiveness of attack location and defense strategies.
Interlaboratory comparison of SARS-CoV2 molecular detection assays in use by U.S. veterinary diagnostic laboratories
Authors: Deng Kaiping , Uhlig Steffen , Ip Hon S. , Lea Killian Mary , Goodman Laura B. , Nemser Sarah , Ulaszek Jodie , Pickens Shannon , Newkirk Robert , Kmet Matthew , Frost Kirstin , Hettwer Karina , Colson Bertrand , Nichani Kapil , Schlierf Anja , Tkachenko Andriy , Reddy Ravinder , Reimschuessel Renate
Published: July 2021

The continued search for intermediate hosts and potential reservoirs for SARS-CoV2 makes it clear that animal surveillance is critical in outbreak response and prevention. Real-time RT-PCR assays for SARS-CoV2 detection can easily be adapted to different host species. U.S. veterinary diagnostic laboratories have used the CDC assays or other national reference laboratory methods to test animal samples. However, these methods have only been evaluated using internal validation protocols. To help the laboratories evaluate their SARS-CoV2 test methods, an interlaboratory comparison (ILC) was performed in collaboration with multiple organizations. Forty-four sets of 19 blind-coded RNA samples in Tris-EDTA (TE) buffer or PrimeStore transport medium were shipped to 42 laboratories. Results were analyzed according to the principles of the International Organization for Standardization (ISO) 16140-2:2016 standard. Qualitative assessment of PrimeStore samples revealed that, in approximately two-thirds of the laboratories, the limit of detection with a probability of 0.95 (LOD95) for detecting the RNA was ≤20 copies per PCR reaction, close to the theoretical LOD of 3 copies per reaction. This level of sensitivity is not expected in clinical samples because of additional factors, such as sample collection, transport, and extraction of RNA from the clinical matrix. Quantitative assessment of Ct values indicated that reproducibility standard deviations for testing the RNA with assays reported as N1 were slightly lower than those for N2, and they were higher for the RNA in PrimeStore medium than those in TE buffer. Analyst experience and the use of either a singleplex or multiplex PCR also affected the quantitative ILC test results.
Small intestinal pseudodiverticulosis in a pony mare
Authors: Leventhal Hannah R. , Hassebroek Anna M. , Carvallo Francisco , McKenzie Harold C.
Published: July 2021

A 14-y-old pony mare was referred after 30-d duration of intermittent pyrexia, anorexia, weight loss, and change in manure consistency. Physical examination revealed a palpable but reducible ventral abdominal mass. Transabdominal ultrasonography revealed multiple distended, hypomotile, and thickened small intestinal loops in close approximation with numerous, well-defined, hyperechoic masses. There was a large amount of echogenic peritoneal fluid; abdominocentesis revealed a neutrophilic and macrophagic inflammatory exudate, and a mixed bacterial population was cultured. Given the poor prognosis, the mare was euthanized. The autopsy findings included a large abdominal abscess, serosanguineous peritoneal fluid with fibrin strands, and ~50 outpouches communicating with the lumen and extending from the anti-mesenteric aspect of the duodenum, jejunum, and ileum. These structures were classified as pseudodiverticula based on the histologic absence of the tunica muscularis layer of the intestinal wall. Pseudodiverticula should be included as a differential etiology in horses when clinical signs consistent with colic, diarrhea, or weight loss are recognized and, when on examination, one or more organized masses are palpated or visualized on transabdominal ultrasound, as well as visualization of small intestinal loops with thickened walls.
Physical Activity and its Influencing Factors in Community-Dwelling Older Adults With Dementia: A Path Analysis
Authors: Li Bei , Huang Xiuxiu , Meng Chenchen , Wan Qiaoqin , Sun Yongan
Published: July 2021

Dementia is prevalent in worldwide, and increases the care burden and potential costs. Physical activity (PA) has been increasingly shown to be beneficial for them. This was a cross-sectional observational study aiming to investigate the status of PA among community-dwelling older adults with dementia in Beijing or Hangzhou, China, and verify the relationships between neuropsychiatric symptoms, activities of daily living (ADL), caregivers’ fear of patients’ falling and their PA using a path analysis approach. The level of PA among 216 included people with dementia was low. PA was related to the neuropsychiatric symptoms, with ADL and caregivers’ fear of patients’ falling have mediation roles. The findings indicated that person-centered strategies related to the management of these symptoms might be helpful to improve ADL, relieve caregivers’ concerns about them falling and consequently foster positive participation in PA.
Outcomes of 2B Adult Acquired Flatfoot Deformity Correction in Patients With and Without Spring Ligament Tear
Authors: Raikin Steven M. , Rogero Ryan G. , Raikin Jared , Corr Daniel O. , Tsai Justin
Published: July 2021

Background:

It is currently unclear how injury to the spring ligament (SL) affects the preoperative presentation of adult acquired flatfoot deformity (AAFD) or the outcome of operative reconstruction. The purposes of this study were to assess the preoperative features and pre- or postoperative function of patients who underwent direct operative repair of an SL tear compared to those without a tear.

Methods:

86 patients undergoing operative correction of grade 2B AAFD by a single fellowship-trained foot and ankle orthopaedic surgeon were reviewed at an average follow-up of 45.9 months. There were 35 feet found to have an SL tear that underwent concomitant debridement and direct repair of the SL. Patient charts were reviewed for demographic information, preoperative visual analog scale (VAS) pain level, and their Foot and Ankle Ability Measure (FAAM) activities of daily living (ADL) and sports subscales. Preoperative radiographic parameters were assessed. Patient outcomes of VAS pain, FAAM-ADL, and FAAM-Sports were collected and compared between groups.

Results:

Those with an SL tear had significantly lower FAAM-ADL and sports scores, with higher VAS pain scores preoperatively. Patient age, talonavicular uncoverage percentage, and talonavicular angle were found to be associated with spring ligament degeneration. At final follow-up, patients demonstrated a significant improvement in all outcome parameters, with no statistical difference found with patient satisfaction, final postoperative VAS pain, FAAM-ADL, or FAAM-Sports in those requiring a repair of their SL as compared to the control group.

Conclusion:

Increasing patient age, increasing talonavicular uncoverage percentage, and decreasing talonavicular angle are all independently associated with increased likelihood of patients with AAFD having an SL tear. At follow-up for operative treatment of grade 2B AAFD flatfoot with our approach, we found no clinical outcomes difference between those without SL tears and those with SL tears treated with concomitant SL debridement and repair.

Level of Evidence:

Level III, retrospective cohort study.
Following the crowd in times of crisis: Descriptive norms predict physical distancing, stockpiling, and prosocial behavior during the COVID-19 pandemic
Authors: Rudert Selma C. , Janke Stefan
Published: July 2021

Individuals engage in a variety of behavioral responses to cope with the COVID-19 pandemic, from complying with or transgressing against physical distancing regulations, to stockpiling or prosocial behavior. We predicted that particularly descriptive social norms are important in driving pandemic-related behavior as they offer guidelines in times of insecurity and crisis. To investigate this assumption, we conducted a longitudinal survey with two measurement points ( n = 1,907) in Germany during the spring of 2020. Results show that descriptive norms (perceived behavior of close others) positively predicted future transgression against distancing regulations, stockpiling, and prosocial behavior over time. In our analysis, we account for previous behavior as well as other potential predictors (subjective threat, personality). In sum, our findings highlight the power of descriptive norms in increasing compliance with pandemic-related regulations and promoting future prosocial behavior.
Who has the power? Manipulating and reclaiming social support in solitary confinement
Authors: Gonzalez Gabriela
Published: July 2021

Social support is often cited as among the most important factors in successful adjustment to prison, reentry, and overall desistance. Yet, few studies have sought to explore the impact of familial social support on incarcerated persons’ experiences in solitary confinement. Analyzing the narratives of men housed in isolation units in one Northwestern state, the present study identifies the variety of experiences they have with social support during isolation, particularly focusing on the prison’s role in structuring relationships between incarcerated persons and their loved ones. Findings reveal that standard communication restrictions in solitary confinement have disparate impacts on differently situated persons living in prisons. Those who are able to maintain familial attachments are able to cope with isolation, first, by maintaining roles in prosocial webs, and second, by accessing material and emotional support, advocacy, and psychological stability. In spite of these benefits, policies and procedures in solitary confinement exacerbate the imprisonment experience and yield negative consequences for prison life, health, family, and prison operations.
Overexpression of HOXA10 promotes the growth and metastasis of nasopharyngeal carcinoma
Authors: Gong Dan , Zhu Hui , Zeng Lei , Hu Ronghuan , Hu Jiali , Ding Jianwu
Published: July 2021

Deregulation of HOX transcription factor family has frequently been observed in multiple human cancers; however, their role in nasopharyngeal carcinoma remains largely unclear. In the present study, we found that HOX gene family is consistently upregulated in nasopharyngeal carcinoma and identified HOXA10 as one of the mostly upregulated HOX genes. Importantly, we show that HOXA10 overexpression is associated with transcriptional activation of multiple oncogenes essential for nasopharyngeal carcinoma carcinogenesis, including S-phase kinase-associated protein 2 (SKP2), calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2), and matrix metalloproteinase 1 (MMP1). Mechanistically, the overexpression of SKP2 induces the degradation of cell cycle inhibitor p27, leading to rapid cell cycle progression and cell proliferation. The overexpression of CAMKK2 is associated with enhanced mTOR signaling activity to meet the increased demand for proteins synthesis in rapid growing nasopharyngeal carcinoma cells. Moreover, MMP1 overexpression facilitates nasopharyngeal carcinoma cell migration and invasion and contributes to cancer metastasis and progression. We thus concluded that HOXA10 overexpression promotes the growth and metastasis of nasopharyngeal carcinoma by transcriptionally activating various oncogenic pathways.
Revolutions in arthroscopic wrist surgeries
Authors: Nakamura Toshiyasu , Cheong Ho Pak , Atzei Andrea , Corella Fernando , Haugstvedt Jan-Ragnar
Published: July 2021

Recent technical and technological developments in wrist arthroscopic surgery allow for advanced treatments of difficult wrist disorders. In this review, world leaders of wrist arthroscopy describe bone graft for scaphoid nonunion, transosseous repair for triangular fibrocartilage fovea avulsion, palmaris longus reconstruction of the triangular fibrocartilage, and arthroscopic reconstruction of the scapholunate and lunotriquetral ligaments.
Presence of anti-acetylated peptide antibodies (AAPA) in inflammatory arthritis and other rheumatic diseases suggests discriminative diagnostic capacity towards early rheumatoid arthritis
Authors: Studenic Paul , Alunno Alessia , Sieghart Daniela , Bang Holger , Aletaha Daniel , Blüml Stephan , Haslacher Helmuth , Smolen Josef S , Gerli Roberto , Steiner Günter
Published: July 2021

Aims:

To determine the diagnostic value of anti-acetylated peptide antibodies (AAPA) in patients with rheumatoid arthritis (RA).

Methods:

Three acetylated peptides (ac-lysine, ac-lysine.inv and ac-ornithine) derived from vimentin were employed to measure AAPA by enzyme-linked immunosorbent assay (ELISA) in sera of 120 patients with early RA (eRA), 195 patients with established RA (est RA), 99 healthy controls (HC), and 216 patients with other inflammatory rheumatic diseases. A carbamylated and a citrullinated version of the vimentin peptide were used additionally. Receiver operating characteristics and logistic regression analyses were used to assess the discriminative capacity of AAPA.

Results:

AAPA were detected in 60% of eRA and 68.7% of estRA patients, 22.2% of HC, and 7.1– 30.6% of patients with other rheumatic diseases. Importantly, AAPA were also present in 40% of seronegative RA patients, while antibodies to the carbamylated peptide were detected less frequently. Diagnostic sensitivity of individual peptides for eRA was 28.3%, 35.8%, and 34% for ac-lysine, ac-ornithine, and ac-lysine.inv, respectively. Positive likelihood ratios (LR+) for eRA versus HC were 14.0, 7.1, and 2.1. While the presence of a single AAPA showed varying specificity (range: 84–98%), the presence of two AAPA increased specificity considerably since 26.7% of eRA, as compared with 6% of disease controls, were double positive. Thus, double positivity discriminated eRA from axial spondyloarthritis with a LR+ of 18.3. Remarkably, triple positivity was 100% specific for RA, being observed in 10% of eRA and 21.5% of estRA patients, even in the absence of RF and ACPA.

Conclusion:

AAPA are highly prevalent in early RA and occur also independently of RF and ACPA, thereby reducing the gap of seronegativity. Furthermore, multiple AAPA reactivity increased the specificity for RA, suggesting high diagnostic value of AAPA testing.
Switching from originator adalimumab to biosimilar SB5 in a rheumatology cohort: persistence on treatment, predictors of drug interruption and safety analysis
Authors: Bruni Cosimo , Gentileschi Stefano , Pacini Giovanni , Bardelli Marco , Tofani Lorenzo , Bartoli Francesca , Baldi Caterina , Cometi Laura , Fiori Ginevra , Nacci Francesca , Cantarini Luca , Guiducci Serena , Moggi-Pignone Alberto , Frediani Bruno , Matucci-Cerinic Marco
Published: July 2021

Aims:

Medical and non-medical switching strategies have been adopted in Europe in the last few years. We aimed to investigate persistence on treatment with a SB5 Adalimumab (SB5) biosimilar after switching from Adalimumab (ADA) originator among patients with inflammatory rheumatic musculoskeletal diseases (iRMD), identifying possible predictors of drug interruption and describing adverse events.

Method:

iRMD patients previously switched to SB5 after at least 6 months of ADA were enrolled. Data on concomitant medications, disease flares, and persistence on SB5 up to the last available follow up were collected retrospectively. Kaplan–Meier and Cox regression models were used.

Result:

A total of 172 patients (106 females, ADA duration 5.8 ± 3.8 years) were enrolled, including 34 rheumatoid arthritis, 59 psoriatic arthritis, and 61 axial spondyloarthritis patients. In a 10 ± 3 months follow up, 65 (37.8%) patients presented with adverse events, with 46 (26.7%) showing a clinically defined disease flare (no disease activity and patient reported outcomes assessment were available); 24 patients interrupted SB5 permanently (among them, 11 back-switched to ADA and 8 were prescribed a different biological therapy). Probability of persistence on SB5 was 94.7% at 6 months and 85.1% at 12 months. Baseline corticosteroid [hazard ratio (HR) 3.209, 95% confidence interval (CI) 1.193–8.635, p = 0.021] and therapy with nonsteroidal anti-inflammatory drugs (NSAIDs) (HR 2.876, 95% CI 1.229–6.727, p = 0.015), as well as the baseline corticosteroid dose (HR 1.200, 95%CI 1.026–1.403, p = 0.022) were predictors of drug interruption.

Conclusion:

Our data on persistence of treatment and adverse events are in line with previous reports. Further large cohort studies may confirm baseline corticosteroid and NSAIDs use as predictors of SB5 interruption, helping to identify patients at higher risk of failure after switching.
Simulation Platform Development for Diabetes and Technology Self-Management
Authors: Faulds Eileen R. , Rayo Michael , Lewis Claudia , Noble Carl W , Gifford Ryan , Happ Mary Beth , Joyce Lilly , Dungan Kathleen
Published: July 2021

Background:

Specialized education is critical for optimal insulin pump use but is not widely utilized or accessible. We aimed to (1) test the usability and acceptability of A1Control, a simulation platform supporting insulin pump education, and (2) determine predictors of performance.

Method:

Rural adult insulin pump users with type 1 diabetes (T1D) participated in a mixed methods usability study in 2 separate rounds. Participants navigated 3 simulations (ie, infusion site occlusion, hypoglycemia, exercise). Net Promoter Score (NPS) and Systems Usability Scale (SUS) were administered. Semi-structured interviews and direct observation were used to assess perceived usability, acceptability and performance. Synthetic Minority Oversampling Technique was used to fit predictive models for visualization of patterns leading to good or poor A1Control performance.

Results:

Participants ( N = 13) were 28-70 years old, 10 used automated insulin delivery and 12 used continuous glucose monitoring (CGM). Mean NPS was 9.5 (range 9-10) and positive sentiment during interviews indicated very high acceptability. SUS (mean 88.5, range 70-100) indicted a high perceived usability. CGM percent wear ≥ 94%, time spent in hypoglycemia ≤ 54 mg/dl of <0.01%, and <70 mg/dl of 0.5% predicted successful site-occlusion scenario performance with 100% accuracy. BOLUS score ≥ 2, TDD ≥ 34, and technology brand predicted exercise scenario success with 100% accuracy. There were an insufficient number of failed hypoglycemia scenarios to assess predictors.

Conclusion:

A1Control shows potential to increase access and frequency of self-management and technology education. Additional study is needed to determine sustained engagement and benefit.
Smallholder Farmers’ Perceptions, Adaptation Constraints, and Determinants of Adaptive Capacity to Climate Change in Chengdu
Authors: Pickson Robert Becker , He Ge
Published: July 2021

This study assessed smallholder farmers’ perceptions, adaptation constraints, and determinants of adaptive capacity to climate change. The study used severity and problem confrontation index estimations to examine the farmers’ perceptions of climate warming and barriers to climate adaptation. The results indicated that the farmers were cognizant of climate change and its adverse impacts on their livelihood. It was evident that most surveyed rice farmers perceived changes in climatic conditions to affect rice production adversely. The farmers claimed that unpredictable weather conditions, limited farm size, inadequate farm labor, scarce water resources, high cost of farm inputs, and insufficient information on weather conditions had impeded their adoption of climate change adaptive strategies. Based on the results of the principal component analysis, economic resources, physical resources, information, human resources, and technology significantly influence smallholder farmers’ responsive ability to climate warming. Therefore, policymakers must design policy frameworks and measures that consider these significant factors explaining farmers’ constraints to climate change adaptation.
“Man-as-Nation”: Representations of Masculinity and Nationalism in Wu Jing’s Wolf Warrior II
Authors: Hu Tingting , Guan Tianru
Published: July 2021

Through an in-depth analysis of gender representation in the box office record-breaking Chinese movie Wolf Warrior II, this study interrogates how the male body is used as a site for the projection of Chinese national power. Furthermore, it illustrates a revival of patriotic pride in China through a contemporary reading of cross-genre action-military films. Developing Shuqin Cui’s notion of “woman-as-nation,” which understands on-screen female victimization in Chinese films as signifying the past suffering of the nation, this study proposes the new concept of “man-as-nation” to explain how the masculine virtues of male protagonists in Chinese films signify the nation’s rejuvenation and strength. Framing male virtue into the paradigms of wu (武), as martial valor, and wen (文), as cultural attainment, this article argues that masculinity has come to symbolize China’s enhanced comprehensive power and to embody its ideological orientation in both global and domestic domains.
A Real Saline Challenge: Diagnosing Primary Aldosteronism in the Setting of Chronic Kidney Disease
Authors: Mirfakhraee Sasan , Rodriguez Maria , Ganji Niloofar , Auchus Richard J. , Hamidi Oksana
Published: July 2021

Primary aldosteronism (PA) is the most common cause of secondary hypertension but remains largely undiagnosed. Chronic kidney disease (CKD) complicates the diagnosis of PA by affecting the biochemical screening evaluation and confirmatory testing, and by increasing the complication rate of adrenal venous sampling (AVS). To raise clinician awareness of the challenges of PA diagnosis in CKD, we present an illustrative case with subsequent review of the literature and discuss some recent developments in PA diagnostic strategies particularly applicable to the CKD population. A 67-year-old man with stage IIIb CKD was suspected of having PA due to treatment with 6 antihypertensive agents and the presence of intermittent hypokalemia. He had a positive biochemical screen for PA, and AVS demonstrated unilateral aldosterone excess. Subsequently, unilateral adrenalectomy resolved his PA, eliminating the patient’s hypokalemia and improving his blood pressure. A MEDLINE literature search revealed 10 studies totaling 11 cases (including our own) of PA diagnosed in the setting of CKD. For each case, the clinical presentation, biochemical data, results of cross-sectional imaging, AVS details, and clinical response to surgery or medical therapy were characterized. The optimal strategy for the diagnosis and management of PA patients with CKD is not known. Although CKD patients often receive screening and subtype testing for PA similar to non-CKD patients, there are challenges in the interpretation of these tests. Novel strategies may include less invasive subtype testing or empiric treatment with mineralocorticoid receptor antagonists but additional studies are necessary.
The Effect of the COVID-19 Lockdown on Bilingual Singaporean Children’s Leisure Reading
Authors: Sun Baoqi , Loh Chin Ee , O’Brien Beth Ann , Silver Rita Elaine
Published: July 2021

Long-term school absences during pandemic lockdowns may result in learning gains and losses much like the summer reading loss, but little is known about the actual effects of such lockdowns. This mixed-methods study examined changes in reading enjoyment, amount and resources in three groups of bilingual children—English-Chinese, English-Malay, and English-Tamil speaking children—during the COVID-19 lockdown in Singapore. Results reveal a lockdown reading gap between children’s stronger language (English) and weaker language (Chinese/Malay/Tamil). Within each language, results show differential reading gains and losses for children who enjoyed and did not enjoy reading in print and digital formats. Children’s reading enjoyment before the lockdown, changes in reading enjoyment and print reading amount during the lockdown in English and Chinese/Malay were significantly correlated. Children preferred print reading over reading digitally both before and during the lockdown, and devices were underutilized for reading purposes.
Regional Variation in Inequality of Educational Opportunity across Europe
Authors: Betthäuser Bastian A. , Kaiser Caspar , Trinh Nhat An
Published: July 2021

A large body of literature documents cross-national variation in the level of inequality of educational opportunity (IEO) among children from different social backgrounds. By contrast, relatively little attention has been given to the extent to which IEO varies within counties and across regions. On the basis of data from the European Social Survey, the authors map variation in IEO across regions in Europe and show that IEO varies substantially within counties. This visualization of the heterogeneity of IEO within European countries highlights the need for researchers and policy makers to extend the current focus on cross-national differences and to investigate and address IEO at the regional level. The visualization raises important questions with respect to the contours, causes, and consequences of cross-regional variation in IEO.
Digital Traces of Sexualities: Understanding the Salience of Sexual Identity through Disclosure on Social Media
Authors: Gilroy Connor , Kashyap Ridhi
Published: July 2021

The authors analyze the expression of sexualities in the contemporary United States using data about disclosure on social media. Through the Facebook advertising platform, the authors collect aggregate counts encompassing 200 million Facebook users, 28 percent of whom disclose sexuality-related information. Stratifying by age, gender, and relationship status, the authors show how these attributes structure the propensity to disclose different sexual identities. There is a large generational difference; younger social media users share their sexualities at high rates, while for older cohorts marital status substitutes for sexual identity. Consistent with gendered expectations, women more often express a bisexual interest in men and women; men are more explicit about their heterosexuality. The authors interpret these variations in sexuality disclosure on social media to reflect the salience of sexual identity, intersected at times with availability. This study contributes to the sociology of sexuality with a quantitative analysis, using novel digital data, of how sexuality is signaled socially.
Non-Classic Congenital Adrenal Hyperplasia in Two Adolescents With Gender Dysphoria
Authors: Wall Emma , Aksglaede Lise , Haahr Mette Ewers , Christiansen Peter , Main Katharina M.
Published: July 2021

The care of transgender individuals is multidisciplinary including medical, surgical, psychiatric, and psychological health professionals. We here report 2 cases of nonclassic congenital adrenal hyperplasia (CAH) coincidently discovered during the clinical and biochemical evaluation prior to hormonal treatment for gender dysphoria. Elevated 17-OH-progesterone and androstenedione led to further investigations including adrenocorticotropic hormone stimulation test and genetic evaluation of 21CYPA2 confirming the diagnosis of CAH in both individuals. The findings may have implications for future surgical treatment and in the case of transwomen for the choice of antiandrogenic treatment. These cases therefore confirm the importance of thorough clinical and biochemical evaluation of transgender individuals before initiation of hormone therapy.
Serum Uric Acid and Coronary Arterial Disease in Predialysis Chronic Kidney Disease Patients
Authors: Raikou Vaia D. , Vlaseros Giannis , Kyriaki Despina , Gavriil Sotiris
Published: July 2021

Background–Aim:

Uric acid is considered a marker of high cardiovascular risk. We investigated the association between serum uric acid and coronary arterial disease (CAD) in pre-dialysis chronic kidney disease (CKD) patients.

Methods:

We enrolled 110 subjects on mean age 69.02 ± 14.3 years old. The participants were categorized for both estimated glomerular filtration rate (eGFR) and albuminuria according to criteria 2012 of the Kidney Disease Improving Global Outcomes. Estimated pulse wave velocity (ePWV) was calculated using an equation including the age and mean blood pressure. The CAD prevalence rate was recorded.

Results:

The patients were divided in two groups according to uric acid cutoff point value related to high ePWV. The patients with higher uric acid were older and they had significantly higher systolic blood pressure, pulse pressure, and parathyroid hormone, but significantly lower eGFR and 1,25(OH)2 Vit D3 levels. The association between high uric acid and both high ePWV and CAD occurrence was found to be significant ( x2 = 6.7, P = .008 and x2 = 4.1, P = .03, respectively), although the relationship with albuminuria was found to be nonsignificant. In a built multifactorial model, the low serum uric acid rather than the high was found to be an independent predictor for CAD demonstration entering traditional and specific confounders.

Conclusion:

The low serum uric acid levels were proved to be a significant predictor for CAD accounting potential covariates, even though the high uric acid per se was found to be connected with cardiovascular disease characteristics including arterial stiffness in predialysis CKD patients.
High-Resolution Esophageal Manometry in the Inpatient Setting: A Tertiary Referral Center Experience
Authors: Antunes Catiele , Zhou Elinor , Abimansour Jad , Assis Daniella , Gutierrez Olaya I. Brewer , Fain Christopher , Stein Ellen , Sloan Joshua A.
Published: July 2021

High-resolution esophageal manometry (HRM) is frequently used in the outpatient setting, but its role in the inpatient setting is unknown. We conducted a retrospective study of patients who underwent inpatient or outpatient HRM. Few differences were noted between groups and 28% of inpatients had an additional intervention. Tolerance of oral diet and diabetes were associated with a lower likelihood of additional intervention. Ultimately, the inpatient HRM group had unique characteristics and few subsequent interventions.
Altered speech patterns in subjects with post-traumatic headache due to mild traumatic brain injury
Authors: Chong Catherine D. , Zhang Jianwei , Li Jing , Wu Teresa , Dumkrieger Gina , Nikolova Simona , Ross Katherine , Stegmann Gabriela , Liss Julie , Schwedt Todd J. , Jayasuriya Suren , Berisha Visar
Published: July 2021

Background/objective

Changes in speech can be detected objectively before and during migraine attacks. The goal of this study was to interrogate whether speech changes can be detected in subjects with post-traumatic headache (PTH) attributed to mild traumatic brain injury (mTBI) and whether there are within-subject changes in speech during headaches compared to the headache-free state.

Methods

Using a series of speech elicitation tasks uploaded via a mobile application, PTH subjects and healthy controls (HC) provided speech samples once every 3 days, over a period of 12 weeks. The following speech parameters were assessed: vowel space area, vowel articulation precision, consonant articulation precision, average pitch, pitch variance, speaking rate and pause rate. Speech samples of subjects with PTH were compared to HC. To assess speech changes associated with PTH, speech samples of subjects during headache were compared to speech samples when subjects were headache-free. All analyses were conducted using a mixed-effect model design.

Results

Longitudinal speech samples were collected from nineteen subjects with PTH (mean age = 42.5, SD = 13.7) who were an average of 14 days (SD = 32.2) from their mTBI at the time of enrollment and thirty-one HC (mean age = 38.7, SD = 12.5). Regardless of headache presence or absence, PTH subjects had longer pause rates and reductions in vowel and consonant articulation precision relative to HC. On days when speech was collected during a headache, there were longer pause rates, slower sentence speaking rates and less precise consonant articulation compared to the speech production of HC. During headache, PTH subjects had slower speaking rates yet more precise vowel articulation compared to when they were headache-free.

Conclusions

Compared to HC, subjects with acute PTH demonstrate altered speech as measured by objective features of speech production. For individuals with PTH, speech production may have been more effortful resulting in slower speaking rates and more precise vowel articulation during headache vs. when they were headache-free, suggesting that speech alterations were related to PTH and not solely due to the underlying mTBI.
Spontaneous giant rectus sheath hematoma in patients with COVID-19: two case reports and literature review
Authors: Nematihonar Behzad , Qaderi Shohra , Shah Jaffer , Bagherpour Javad zebarjadi
Published: July 2021

Introduction

Coronavirus disease 2019, COVID-19, as a global public health emergency, has come with a broad spectrum of clinical manifestations and complications. In this study, we present a unique complication of this disease.

Presentation of cases

(A) A 65-year-old woman with a known case of COVID-19; on the second day of admission, the patient presented sudden tachycardia and hypogastric pain; on abdomen physical examination, a huge lower abdominal tender mass was noticed. (B) A 50-year-old woman with COVID-19, 4 days after admission, started complaining of tachycardia, pain, and mass in the lower abdomen. On abdomen physical examination, a huge lower abdominal tender mass was noticed. Both of the patients underwent an abdomen CT scan which confirmed a huge rectus sheath hematoma (RSH). Both of the patients underwent angioembolization of the inferior epigastric artery. The patient recovered completely and no evidence of further expansion was seen after 2 weeks of follow-up.

Discussion

Hemorrhagic issues in COVID-19 patients remain poorly understood. Physicians should discuss risks of RSH in patients where continuous anticoagulation therapy will be reinstated. With increased clinician awareness of the need for RSH screening in COVID-19 patients with acute abdominal pain, the interprofessional team of healthcare providers can maximize patient safety and reduce hospitalization time, especially in high-risk patients at risk for unnecessary surgery.

Conclusions

These two reports and literature review demonstrate the need of active surveillance for possible hemorrhagic complications in patients with COVID-19 infection.
Laparoscopic ureterolithotomy for large lower ureteral stone: a case series report
Authors: Zia Hamidreza , Zadeh Seyed Saeed Tamehri , Khatami Fatemeh , Aghamir Seyed Mohammad Kazem
Published: July 2021

Background

Identifying the precise location of the lower ureter is crucial in not only ureteral surgeries but also the other surgeries that may cause ureteral injury. Although a variety of approaches have been applied to detect the location of the lower ureter, the majority of them had an association with several complications or be difficult to perform perfectly or be time-consuming.

Case presentation

Seven patients with distal ureteric stones of the size ranged from 2 to 3 cm. All patients entered the study after signing the informed consent, and the case report is based on CARE guidelines. After specifying the inner ring of the inguinal canal, the posterior peritoneum was opened and dissected from an area of 2 cm medial and 2 cm inferior to the inner ring. Thereafter, the stone was extracted from the precise location of them, which was identified by ureteral pinching.

Conclusion

We assumed that we were easily able to identify the site of the lower ureter through 2 cm medial and 2 cm inferior to the inner ring. The result of our study on seven patients demonstrated that this maneuver can minimize the time of surgery and no complications have been seen while this approach was applied.
Serum gonadotropins, cortisol, PSA, and micronutrient levels among men with prostate carcinoma
Authors: Olooto Wasiu Eniola , Oyelekan Abimbola Adeola , Adewole Omolara Oluwawemimo , Fajobi Adeniyi Olugbenga , Adedo Ayyuub Abayomi , Olasimbo Oladipupo
Published: July 2021

Background

Prostate cancer (PrCa) is a malignant tumour of the prostate that has many associated risk factors. There is continuous rise in the incidence among adult blacks which is a reflection of racial differences in testosterone concentrations.

Methods

The study involves 50 PrCa patients attending or referred to two tertiary health Institutions and 25 healthy men as controls. Weight and height of participants were measured, and body mass index (BMI) was calculated. Ten millilitres of venous blood sample was collected from each participant, allowed to clot, and then centrifuged at 5000 rpm for 5 min at room temperature (22–28 °C) to obtain the serum. Serum cortisol, testosterone, follicle-stimulating hormone (FSH), luteinizing hormone (LH), total prostate-specific antigen (TPSA), free prostate-specific antigen (FPSA), selenium, copper, magnesium, and zinc were determined. Prostate ultrasonography and biopsy were also done for histopathological studies.

Result

From this study, a significant increase (p < 0.05) in weight, BMI, serum FPSA, TPSA, and copper; a non-significant increase (p > 0.05) in serum cortisol, testosterone; a significant decrease (p < 0.05) in serum LH, selenium, zinc, and magnesium; and a non-significant decrease (p > 0.05) in serum FSH were observed among people living with PrCa when compared to the controls. However, no significant difference (p > 0.05) was observed in the height between the two groups. Ultrasonography and histology revealed evidence of prostatitis, hypertrophy, and carcinoma among the test group.

Conclusion

It can be concluded that PrCa is associated with increase serum cortisol, testosterone, and copper; and decreased serum LH, FSH, selenium, zinc, and magnesium concentrations and combination of biochemical, ultrasonographic, and histologic features are of diagnostic importance.
Prognostic role and clinicopathological features of SMAD4 gene mutation in colorectal cancer: a systematic review and meta-analysis
Authors: Fang Tian , Liang Tingting , Wang Yizhuo , Wu Haitao , Liu Shuhan , Xie Linying , Liang Jiaying , Wang Chang , Tan Yehui
Published: July 2021

Background

Approximately 5.0–24.2% of colorectal cancers (CRCs) have inactivating mutations in SMAD4, making it one of the frequently mutated genes in CRC. We thus carried out a comprehensive system review and meta-analysis investigating the prognostic significance and clinicopathological features of SMAD4 gene mutation in CRC patients.

Methods

A detailed literature search was conducted in PubMed, Web of Science and Embase databases to study the relationship between SMAD4 mutations and the demographic and clinicopathological characteristics in CRC patients. The hazard ratios (HRs) with 95% confidence intervals (CI) were used to evaluate the effect of SMAD4 mutations on overall survival (OS) and progression-free survival (PFS)/recurrence-free survival (RFS).

Results

Ten studies enrolling 4394 patients were eligible for inclusion. Data on OS were available from 5 studies and data on PFS/RFS were available from 3 studies. Comparing SMAD4-mutated CRC patients with SMAD4 wild-type CRC patients, the summary HR for OS was 1.46 (95% CI 1.28–1.67, P = 0.001), the summary HR for PFS/RFS was 1.59 (95% CI 1.14–2.22, P = 0.006). In terms of clinicopathology parameters, 9 studies have data that can be extracted, SMAD4 mutations were associated with tumor location (odds ratio [OR] = 1.15, colon/rectum, 95% CI 1.01–1.31, P = 0.042), TNM stage (OR = 1.28, stage IV/I–III, 95% CI 1.03–1.58, P = 0.025), lymph node metastasis (OR = 1.42, N1 + N2/N0, 95% CI 1.20–1.67, P < 0.001), mucinous differentiation (OR = 2.23, 95% CI 1.85–2.70, P < 0.001) and rat sarcoma viral oncogene homolog (RAS) mutation status (OR = 2.13, 95% CI 1.37–3.34, P = 0.001). No connection was found with age, gender, tumor grade, microsatellite instability status and b-viral oncogene homolog B1 mutation status. Besides, publication bias was not observed in any study.

Conclusions

This meta-analysis suggests that SMAD4 mutation was associated with OS, PFS/RFS, and clinicopathological parameters, including tumor site, disease stage, RAS status, lymph node metastasis and mucinous differentiation. Our meta-analysis indicated that SMAD4 mutations could predict the poor prognosis and aggressive clinicopathological characteristics of CRC. More large-sample cohort studies are needed to confirm this conclusion. Since SMAD4 mutations are closely related to RAS mutations, their relationship warrants further investigation.
Effectiveness of a programable body-worn digital hearing aid for older adults in a developing country: a randomized controlled trial with a cross-over design
Authors: Kasemsiri Pornthep , Yimtae Kwanchanok , Thanawirattananit Panida , Israsena Pasin , Noymai Anukool , Laohasiriwong Supawan , Vatanasapt Patravoot , Siripaopradith Pipop , Kingkaew Pritaporn
Published: July 2021

Background

Hearing aids are important assistive devices for hearing rehabilitation. However, the cost of commonly available commercial hearing aids is often higher than the average monthly income of individuals in some developing countries. Therefore, there is a great need to locally produce cheaper, but still effective, hearing aids. The Thai-produced P02 hearing aid was designed to meet this requirement.

Objective

To compare the effectiveness of the P02 hearing aid with two common commercially available digital hearing aids (Clip-II™ and Concerto Basic®).

Methods

A prospective, randomized controlled trial with a cross-over design was conducted from October 2012 to September 2014 in a rural Thai community. There were 73 participants (mean age of 73.7 ± 7.3 years) included in this study with moderate to severe hearing loss who were assessed for hearing aid performance, including probe microphone real-ear measurement, functional gain, speech discrimination, and participant satisfaction with the overall quality of perceived sound and the design of the device.

Results

There were no statistically significant differences in functional gain or speech discrimination among the three hearing aids evaluated (p-value > 0.05). Real-ear measurements of the three hearing aids met the target curve in 93% of the participants. The best real-ear measurement of the hearing aid following the target curve was significantly lower than that of Clip-II™ and Concerto Basic® (p-value < 0.05) at high frequency. However, participants rated the overall quality of sound higher for the P02 hearing aid than that of Clip-II™ but lower than that of Concerto Basic®(p-value > 0.05). Participants revealed that the P02 hearing aid provided the highest satisfaction ratings for design and user-friendliness with statistical significance (p-value < 0.05).

Conclusion

The P02 hearing aid was an effective device for older Thai adults with hearing disabilities. Additionally, its modern design, simplicity of use, and ease of maintenance were attractive to this group of individuals. These benefits support the rehabilitation potential of this hearing aid model and its positive impact on the quality of life of older adults in developing countries.

Trial registration

This study was registered underClinicaltrial.govNCT01902914. Date of registration: July 18, 2013.