bluuebunny/crossref_metadata_2025 huggingface dataset:
Investigating the Misguided Path of the Superior Epigastric Artery: An Explorative Anatomical Study of 40 Specimens
Authors: Ahmic Edin , Swatek Paul , Mykoliuk Iurii , Busau Anton , Lindenmann Jörg
Published: October 2024

Background: This study addresses a longstanding discrepancy between the observed course of the superior epigastric artery in anatomical specimens and its depiction in many German-language anatomy textbooks. While the artery typically runs ventral to the diaphragm, textbooks inaccurately describe it as passing through the sternocostal triangle (Larrey's fissure). Methods: Anatomical dissections were performed on 40 formalin-fixed cadavers at the Medical University of Vienna. The thoracic and abdominal walls were dissected, and the course of the superior epigastric artery was documented. Literature from the time of Dominique Larrey to present was reviewed to trace the origin of the incorrect anatomical description.Discussion: Findings confirm that the superior epigastric artery does not traverse Larrey's space but remains ventral to the pleural and peritoneal cavities. The erroneous description appears to have originated from a 19th-century misinterpretation by Joseph Hyrtl and was perpetuated in German-language textbooks.Conclusion: The study refutes the long-standing but incorrect description of the superior epigastric artery's course in German-language anatomy textbooks. The findings highlight the importance of revising anatomical literature to correct historical inaccuracies.
Myval Transcatheter Heart Valve: The Future of Transcatheter Valve Replacement and Significance in Current Timeline
Authors: Kilic Teoman , Coskun Senol , Mirzaminidov Didar , Yilmaz Irem , Yavuz Sadan , Sahin Tayfun
Published: October 2024

The Myval is a balloon-expandable transcatheter heart valve (THV) devel-oped by Meril Life Sciences Pvt. Ltd. that has innovative operator-friendly de-sign which aids to improve deliverability and features precise deployment. Vari-ous clinical studies demonstrate its effectiveness and safety, making it a promis-ing choice in valvular interventions. Myval has been successfully utilized as a transcatheter aortic valve implanta-tion (TAVI) device in cases with conduction disturbances, bicuspid aortic valve anatomy, non-calcified aortic regurgitation, dysfunctional stenosed right ventric-ular outflow tract (RVOT) conduits, pulmonary valve replacement, mitral valve replacement, Vave-in-valve and Valve-in-ring implantation procedures. Myval’s diverse sizes are also of key importance in complex cases of large and complex annuli anatomy. Further long-term studies are needed to consolidate these results.
Its introduction signifies a significant advancement in cardiology, aiming to enhance patient outcomes and quality of life. In the present review, we provide an update on new-generation Myval THVs and review the available clinical data published till date with an emphasis on diverse use in specific clinical scenarios.
Development of a Problem-Based Learning-Oriented Interactive E-worksheet on Chemical Equilibrium to Enhance Students' Scientific Literacy Skills
Authors: Mufidah Rachma , Dwiningsih Kusumawati
Published: October 2024

Indonesian students' scientific literacy scores decreased by 13 points from PISA 2018, indicating that the scientific literacy skills of participants in Indonesia are low. One area of concern is students' understanding of chemical equilibrium, which is essential because it is a prerequisite for grasping subsequent materials. This study aims to assess the feasibility of interactive e-worksheets as a learning medium for chemical equilibrium material in terms of validity, practicality, and effectiveness. According to Thiagarajan, the research employs the 4-D research and development model, which includes Defining, Designing, Developing, and Disseminating but is limited to the development stage. A limited trial was conducted using a one-group pretest-posttest research design. Validation results show that the interactive e-worksheet is valid with a mode value of 4 in content, presentation, language, and design. The validity test results yielded a mode value 4 for both content and construct validity. The practicality test results indicated a high percentage of practicality with very practical criteria. The effectiveness test, analysed using n-gain, showed an n-gain value of 0.78 with high criteria, and the paired sample t-test results indicated a P-value of 0.000, confirming that the post-test scores were significantly higher than the pretest scores. Thus, the PBL-oriented Interactive e-worksheet can improve students' scientific literacy skills.
Effectiveness of the pH Master Application on Acid-Base Concepts as a Digital Alternative to Conventional Laboratory Practices for Enhancing Student Learning Outcomes"
Authors: Kusumawati Agnys Dewi , Ariani Sri Retno Dwi , Indriyanti Nurma Yunita
Published: October 2024

Traditional Chemistry Laboratories, such as acid-base reactions, are hard to demonstrate for present-day students in their lab classes when they need to have the knowledge exchange we had, graduating (and teaching) with mortar boards lined up and ready for weddings. The Evaluation Of The Digital Platform “pH Master” For Enhancing Chemistry Student Performance Through A Virtual Imitation of Traditional Lab Practices The study used Akker's research and development model, including initial studies, product design, testing products, and trials. Validation was done using the Aiken formula by two expert validators and three practitioners for all items with a V value greater than 0.87. Surveys for needs analysis involved 45 students, and the
learning effects were assessed with 90 students across three
schools. Results Students responded favourably to the pH Master app and perceived ineffable pedagogical value. Most students agreed on the necessity of doing practical activities about what was being learned, and almost all also had trouble understanding study materials specifically related to acids and bases. The results showed a statistically higher mean n-gain value in the experimental group than in control one (0.6622 versus 0.5691) by independent t-test across three schools at p < 0,001 significance level between the two groups. This then confirms that the media created did support student learning. This study highlights the potential of the pH Master app to enhance student learning experience and active involvement in chemical education, which suggests a promising approach towards digitalising conventional practical work.
Synthesis and Characterization of Polyaniline/CuO Nanocomposites with Various Temperature
Authors: Sunarya Risa Rahmawati , Sidik Yosi Yosiva , Islamiati Fitri Nur
Published: October 2024

Polyaniline (PANI) metal oxide composites are known for their high electrical conductivity, environmental stability, and enhanced mechanical strength, making them valuable in applications such as sensors, batteries, and electromagnetic shielding. This study focuses on synthesizing and characterizing PANI/CuO nanocomposites to examine their structural, morphological, and functional properties at different synthesis temperatures. By integrating the conductive polymer PANI with copper oxide (CuO), a p-type semiconductor with a narrow band gap, the material’s capabilities are significantly enhanced. The oxidative polymerization of aniline, the process by which PANI is formed, requires precise control of oxidizing agents and reaction conditions, as these factors directly affect the polymerization, conductivity, and overall properties of the resulting nanocomposite. The PANI/CuO nanocomposites were synthesized at three different temperatures: 10℃, 25℃, and 50℃, to determine how temperature affects their characteristics. Fourier Transform Infrared (FTIR) spectroscopy and Scanning Electron Microscopy (SEM) were employed to analyze these nanocomposites. FTIR results revealed shifts in the quinoid and benzenoid rings, indicating hydrogen bonding between the NH group of PANI and the CuO surface, which accelerates charge transfer. The SEM analysis showed that while pure PANI exhibits a uniform globular morphology, the PANI/CuO nanocomposites display a nanorod morphology. These morphological differences impact the surface area and electrical conductivity of the composites, highlighting the significance of temperature in tailoring the material's properties for specific applications.
Educación integral en sexualidad para infancias indígenas migrantes
Authors: Salinas Boldo Claudia , Be Ramírez Pedro Antonio
Published: October 2024

La educación sexual es algo que todas las personas hemos recibido de manera formal –en la escuela- o informal -en nuestra casa, con las amistades o en los medios de comunicación- El problema de la educación sexual informal, es que está basada en el sentido común y en creencias, mientras que la educación formal que recibimos en la escuela, generalmente se ha limitado a tratar los siguientes temas: pubertad, embarazo e infecciones de transmisión sexual.
Interculturalidad, educación y salud mental en las cárceles en América Latina
Authors: López Estrella Armando , Estrella Castillo Damaris
Published: October 2024

Las cárceles en América Latina enfrentan desafíos monumentales, uno de los cuales es el manejo de la salud mental de sus reclusos. La interculturalidad crítica y la educación emergen como elementos fundamentales para abordar esta problemática de manera integral. Este artículo explora cómo un enfoque que promueva la interculturalidad crítica en la educación puede ayudar a mejorar la gestión de la salud mental en las cárceles de América Latina. Se discuten 3 apartados: a) el desafío del sistema penitenciario en América Latina y su impacto en la salud mental, b) el poder transformador de la educación en contexto carcelario y c) la interculturalidad crítica como enfoque transformador.
Populismo mediático e interculturalidad política en México
Authors: Peñúñuri Soto Amílcar
Published: October 2024

El presente trabajo intenta trazar una línea argumentativa para analizar los diferentes esfuerzos del populismo mediático en su intención de establecer una narrativa con tintes y aspiraciones pedagógicas, de referentes político - culturales, claramente dirigidas a un sector ideológico y emocional de la ciudadanía, así como el proceso de edificación de un lenguaje claramente en oposición y hasta cierto punto confrontacional con otras dimensiones y formas de analizar el imaginario público.
Tensiones político-epistémicas de la educación inclusiva e intercultural
Authors: González-Machado Emilia Cristina , Santillán-Anguiano Ernesto Israel
Published: October 2024

En este escrito nos permitiremos conversar y preguntarnos, a propósito de nuestras preocupaciones, pensares, sentires y saberes; cada quién, desde nuestro espacio de enunciación, que aun cuando formamos parte de un institución social, que refleja y sostiene estructuralmente las entrañas del sistema capital globalizado, buscamos grietas en donde sea posible.
Construcción de ciudadanías mexicanas: entre condiciones y contradicciones
Authors: Gaytán Martínez Víctor Hugo
Published: October 2024

Entre la condición de la Idea y lo Real en la ciudadanía hay una distancia epistemológica y pragmática extensa. La distancia, inconmensurable por las características y la complejidad entre lo que debería ser y lo que realmente es, arrastra, al que medita sobre este asunto, a cierto grado de pesimismo traducido en gestos de desesperación y desasosiego.
Promoción de Derechos Humanos en la niñez y juventud migrante a través del cuento
Authors: Barrientos Téllez Sandra Elizabeth , Tapia Quiñones Jared Alejandra
Published: October 2024

El presente proyecto es resultado de la investigación desarrollada durante los años 2020-2021, con el cual se buscó encontrar diversas alternativas hacia la educación migrante y así poder mejorar el nivel de vida de la población infantil y juvenil, enfocado en el reconocimiento de sus derechos humanos a través del cuento. El cual se llevó a cabo a través del programa, Escuela Digital para la niñez migrante y refugiada, mismo que se impartió dentro del albergue Embajadores de Jesús, ubicado en la ciudad de Tijuana, Baja California, México.
Niñez migrante: ¿Quiénes acceden a la educación?
Authors: Reyes Piñuelas Erika Paola
Published: October 2024

Se describen algunos factores asociados al seguimiento escolar de la niñez migrante. El flujo de migrantes extranjeros y nacionales en la zona fronteriza de Baja California, México ha sido una característica constante a lo largo de la historia, las personas que se mudan de otras partes de México a esta zona en busca de oportunidades de trabajo y una mejor calidad de vida, también son ciudades de paso hacia su destino final, el vecino país EEUU, esto ha estado ocurriendo durante décadas y se ha experimentado un crecimiento significativo de su población a lo largo del tiempo.
Interculturalidad y pedagogías del Sur para la descolonización de la universidad
Authors: Cardona Hernández Leidy Carolina , Fisgativa Sabogal Carlos Mario
Published: October 2024

Teniendo en cuenta que las humanidades y las ciencias sociales se han constituido bajo la matriz o patrón colonial que instaura formas totalitarias de regulación e individuación, cuyo modo de instalarse en las instituciones educativas reproduce una mirada del mundo que es hegemónica y occidental, buscamos problematizar los modelos institucionales y epistemológicos de origen moderno/colonial que estructuran las universidades, sus distribuciones en saberes y disciplinas, para mostrar que pueden ocuparse de otro modo y agrietarse desde las apuestas de la interculturalidad.
Enseñanza contracolonial - transcultural de lenguas: acogimiento y poesía
Authors: Ruiz Paggioro Sessino Toledo Barbosa Isabelle
Published: October 2024

Enseñar confluye con el contexto histórico, político, social que, en este caso, me hacía reconocer la violencia brasileña hacía Paraguay. En un día de examen oral me despertó la idea que ahora aplico. Cada estudiante escogería un poema del libro que tenía yo disponible. Empecé por mí y pedí, en secuencia, escogieran otro para leer después; les evaluaría según su lectura y las ideas que expusieran.
La colonialidad pedagógica de las culturas digitales: De la instrucción a la programación
Authors: Magallanes Payán José Arturo
Published: October 2024

El presente trabajo ofrece un análisis descriptivo de las tendencias de una cultura digital global, y cómo se relacionan estas con un rediseño del sentido común asociado a una pedagogía informal, cuya base pedagógica es la instrucción.
The Effect of GCG, CSR Disclosure, and Investment Decisions on Firm Value
Authors: Ni Made Puspita Dewintasari  , I Gusti Ayu Made Asri Dwija Putri  , Ni Made Dwi Ratnadi  , Gede Juliarsa
Published: October 2024

Investors' opinion of a company's competence in resource management is known as firm value. Demand and supply factors in the stock market determine the firm's value, reflected in its stock price. According to investor opinions, a company's high worth is represented in both its present success and its prospects for the future. In general, a number of elements, including the stock market price, net income per share, the cost of capital, and assets and liabilities, define a company's worth. This research proposes examining the impact of managerial ownership, audit committee size, corporate social responsibility disclosure, and investment decisions on firm value. This is a quantitative descriptive study made applying purposive sampling. A total of 171 observations of property and real estate firms listed on IDX during three observation periods of 2020-2022. The data was analyzed using multiple linear regression. The study found that managerial ownership contributes positively to firm value, whereas investment decisions, corporate social responsibility disclosure, and audit committee size does not influence on firm value. This study emphasizes the importance of management ownership in efforts to raise a company's value by giving empirical data to support the application of the theory of agency and the theory of signaling in this research. It will also be expected to serve as input for the companies under review.
The Relationship of Materialism and Financial Literacy on Students' Financial Management
Authors: Novita Arief  , Riyanti  , Sahrir
Published: October 2024

Study This aim For know connection materialism and literacy finance to management finance student. Types of research This use approach study quantitative through analysis regression multiple use SPSS application. Object in study This is students across the city palopo . Deep Sampling​ study This use accidental sampling method with total of 120 respondents . Research result show that that materialism No influential or not significant to management finances for students in Palopo City, this give results that level caution students in Palopo City be careful in use the money so that make student can manage it his finances with OK, more rational or not will behave consumer. For literacy finance  influential positive and significant to management finance, which means the more tall literacy finance so will make management generated finances​ become the more Good.
 
Keyword: Materialism , Literacy Finance , Management Finance
Analysis Of The Role Of Internal Control And School Committees In Managing School Operational Assistance Funds (Bos) On The Operational Performance Of Sdn Lubang Buaya 05
Authors: Saely Audy Kurnia Tri , Ulupui I gusti Ketut Agung , Pahala Indra
Published: October 2024

This study analyzes the role of internal control and the school committee in the management of the School Operational Assistance Fund (BOS) and its impact on operational performance at SDN Lubang Buaya 05 The background of this study is based on the importance of education as a key element in the progress of the nation and the challenges of managing BOS funds, which often face obstacles of fraud and non-transparency. This study examines the conformity of BOS fund management with the prevailing regulations (Permendikbud No. 63 of 2022) as well as the monitoring and reporting mechanisms implemented. The results show that strong internal controls and the active role of school committees in overseeing BOS funds can improve the effectiveness and efficiency of the use of funds and reduce the risk of fraud. This study also identified internal and external factors that influence the effectiveness of internal control in achieving operational performance. The findings provide recommendations for improving the governance and supervision of BOS funds in primary schools.
The Influence of Perception of Ease and Perceived Usefulness on Interest in Using E-Money in FE UNJ Students Through Trust as a Mediation Variable
Authors: Maharani Fauziah , Usman Osly
Published: October 2024

This study aims to determine the influence of perception of ease and perceived usefulness on interest in using E-Money in FE UNJ students through trust as a mediation variable. This study used quantitative methods by using questionnaires as a way of data collection. The population in this study is FE UNJ students who are still active as students and use E-Money totaling 998 people. Determination of the sample using the slovin formula so that the sample used amounted to 285 students. The technique used for sampling uses purposive sampling. The measurement scale uses a Likert scale of 1-5. Data analysis techniques use PLS analysis which consists of measurement model analysis, structural models, and hypothesis testing using SmartPLS 4.0. Based on the results of the study, the results show that the perception of ease, perceived usefulness, and trust has a positive and significant effect on the interest in using E-Money, the perception of ease and perceived usefulness has a positive and significant effect on trust, trust has a positive and significant effect on the interest in using E-Money, trust is able to mediate positively the influence of perceived usefulness but unable to mediate the influence of perception of ease on interest in using E-Money. This discovery implies that interest in using E-Money is influenced by several factors. For E-Money service providers, this research can provide promotions regarding the ease and benefits provided by E-Money to students so as to expand the market and increase trust by ensuring security when making transactions, and providing good service.
The Influence of Good Corporate Governance on Financial Performance in Indonesian Islamic Banking
Authors: Triasdinda Dhea , Rismawati  , Rusli Andika
Published: October 2024

This study examines the impact of Good Corporate Governance (GCG) on the financial performance of Sharia banking in Indonesia Tbk. Analyzed GCG variables include the Board of Commissioners, Board of Directors, Independent Commissioners, Sharia Supervisory Board, and Audit Committee. Using a quantitative method with multiple linear regression analysis, the study employs secondary data from annual reports of Sharia banking in Indonesia Tbk. Normality tests were conducted using the One-Sample Kolmogorov-Smirnov test, while heteroscedasticity tests were performed using a scatterplot of residuals against standardized predicted values.Results indicate that none of the independent variables significantly impact financial performance, with p-values well above 0.05. Additionally, the F-test (ANOVA) shows that the independent variables collectively do not significantly impact financial performance, with an F value of 0.243 and a p-value of 0.939. The very low coefficient of determination (R²) of 0.048 suggests that the regression model explains only 4.8% of the variation in financial performance.The implementation of GCG principles at Bank Muamalat Syariah Tbk has not effectively improved financial performance. Therefore, evaluation and improvement of GCG implementation are needed, along with consideration of other factors potentially influencing financial performance. Recommended measures include enhancing the capacity of the Board of Commissioners and Board of Directors, optimizing the role of Independent Commissioners, and increasing the effectiveness of the Sharia Supervisory Board and Audit Committee to improve the bank's financial performance.
Customer adoption of Chat GPT for web development and programming assistance in the Zimbabwe tech industry
Authors: Sibanda Alexander
Published: October 2024

ChatGPT, an advanced conversational AI model by OpenAI, signifies a significant leap in human-computer interaction. Optimized for dialogue, ChatGPT has the potential to transform web development and programming support. In Zimbabwe, 60% of IT programmers express concerns about UI/UX design, while 70% face challenges in service quality due to software flaws and inadequate testing. This study investigates ChatGPT's application in Zimbabwe's tech industry for web development and programming support, and its impact on organizational performance. Employing an integrated Delone and McLean IS Success Model, the research examines adoption trends, barriers, and benefits of integrating ChatGPT into development workflows.A quantitative approach was utilized, employing survey data and statistical methods. A 5-point Likert Scale survey was distributed to 30 Zimbabwean ICT workers. Data analysis with SmartPLS 3.0 included descriptive and confirmatory factor analyses to assess reliability (Cronbach's alpha, composite reliability) and validity (factor loadings, AVE, HTMT ratio). Results indicate that ChatGPT significantly influences system, information, and service quality, enhancing user satisfaction and organizational benefits, with system quality exerting the strongest impact. Moreover, system quality positively affects organizational performance, though the moderating role of flexible organizational culture was insignificant. Recommendations include enhancing training data tailored to local technological needs, integrating real-time data sources, offering a paid version for updated data, ensuring robust error handling for service quality, providing educational resources, implementing feedback mechanisms, conducting developer training programs, and promoting cross-functional collaboration.
The Effect of Entrepreneurship Education and Technological Advancement on the Entrepreneurial Intention
Authors: Alicia Megawati
Published: October 2024

This study aims to determine the effect of entrepreneurship education and technological advancement in influencing the entrepreneurial intention of vocational high school students (SMK) in Jakarta. Entrepreneurial intention is a desire from within a person that is formed from a mindset to create a business that is beneficial to oneself and others with innovation and creativity. Entrepreneurial intention needs to be increased considering the need to increase young entrepreneurs and to reduce unemployment in Indonesia, especially Jakarta. The phenomenon of entrepreneurship education and technological advancement that should support business learning opportunities to increase entrepreneurial intention, does not seem to be able to fully increase students' entrepreneurial intention.
This research was conducted in Jakarta using a quantitative approach with a descriptive and correlational approach. The data used is primary data obtained by distributing questionnaires. The analysis method uses multiple linear regression analysis, validity and reliability tests, classical assumption tests and hypothesis testing using the SPSS version 29 application. The research sample was 200 vocational students in Jakarta using non-probability sampling techniques and purposive sampling. This research answers that Entrepreneurship Education effect the Entrepreneurial Intention,Technological Advancement effect the Entrepreneurial Intention, and Entrepreneurship Education and Technological Advancement effect the Entrepreneurial Intention
Unlocking FinTech's Potential: The Crucial Role of Cybersecurity and Trust in Malaysia
Authors: Rozali Salfariza , Muhamat Amirul Afif Muhamat , Humaidi Norshima , Abd Rashid Mohd Hafiz
Published: October 2024

The rapid emergence of financial technology (FinTech) has revolutionized the banking industry, propelling it into the digital age. However, this transformative shift has also brought critical concerns regarding data protection and cybersecurity to the forefront, issues that remain unresolved and pose significant challenges for the sector. Cybersecurity and trust are paramount as they directly influence customer adoption and the overall success of FinTech initiatives. This study delves into existing research within the Malaysian context, analyzing previous findings to identify the potential precursors that have shaped current trends in the region. By examining historical data, socio-economic factors, and relevant policies, this research aims to uncover the underlying forces that have contributed to the present-day landscape.
Reach and Engagement With Population Health Management Interventions to Address COVID-19 Among Safety-Net Health Care Systems
Authors: Schlechter Chelsey R. , Kuzmenko Tatyana V. , Orleans Brian , Wirth Jennifer , Kaphingst Kimberly A. , Gibson Bryan , Kawamoto Kensaku , Siaperas Tracey , Pruhs Alan , Dinkins Courtney Pariera , Greene Tom , Zhang Yue , Chipman Jonathan J. , Friedrichs Michael , Lam Cho Y. , Pierce Joni H. , Borsato Emerson P. , Cornia Ryan C. , Stevens Leticia , Martinez Anna , Bradshaw Richard L. , Hess Rachel , Fiol Guilherme Del , Wetter David W.
Published: October 2024

Interventions designed to address COVID-19 needed to be rapidly scaled up to the population level, and to address health equity by reaching historically marginalized populations most affected by the pandemic (e.g., racial/ethnic minorities and rural and low socioeconomic status populations). From February 2021 to June 2022, SCALE-UP Utah used text messaging interventions to reach 107 846 patients from 28 clinics within seven safety-net health care systems. Interventions provided informational and motivational messaging regarding COVID-19 testing and vaccination, and were developed using extensive community partner input. ( Am J Public Health. 2024;114(11):1207–1211. https://doi.org/10.2105/AJPH.2024.307770 )
Blood-triggered Efficient Self-sealing and Tissue Adhesive Hemostatic Nanofabric
Authors: Liu Haiqing , fang yan , wang linyu , ni peng , xu zhibo , wang ziying , Weng Yunxiang , Chen Qinhui
Published: October 2024

Current hemostatic fabric often encounters the issue of blood seeping or leaking through the fabric and at the junctions between the fabric and tissue, leading to extra blood loss. Herein, we developed an efficient hemostatic nanofabric composed of anionic and cationic nanofibers through a double-coaxial electrospinning technique. Upon contact with wound, the porous nanofabric can absorb the interfacial blood and self-seal to form a compact physical barrier through interfiber bonding, preventing blood from longitudinally penetrating the fabric. Moreover, this nanofabric exhibits strong tissue adhesiveness, inhibiting blood seeping out at the seam of the fabric and tissue. Its hemostatic performance in animal injuries surpasses that of standard cotton gauze and Combat GauzeTM. In the pig femoral artery injury, the blood loss from the nanofabric was only ca. 8% of that from Combat GauzeTM. This nanofabric exhibited antibacterial property, excellent biocompatibility, and promotes wound healing. Our work demonstrates that this strategy for designing hemostatic fabric has great potential.
Effects of Resistance Training Exercise on Cognitive Functioning in Older Adults with and without Chronic Obstructive Pulmonary Disease (COPD)
Authors: Andreassen Marita , Larsen Even Olai , Mølmen Knut Sindre , Ask Torvald , Lugo Ricardo Gregorio
Published: October 2024

Introduction:
A positive relationship between physical exercise training and cognitive function in humans is well-established. However, knowledge of how resistance exercise training affects patients with chronic obstructive pulmonary disease (COPD) is limited. COPD is usually followed by declines in cognitive functioning. Thus, an examination of how resistance exercise training affects cognitive functioning in COPD is warranted. The purpose of this study was to examine the effect of resistance exercise training on cognitive functioning in COPD participants.
Method
Thirty-six older adults (> 65 years) with COPD (n = 8) and healthy controls (n = 28) completed the study protocol. Cognitive functioning using the Montreal Cognitive Assessment (MoCA) was measured before and after a 13-week resistance exercise training intervention.
Results
For the healthy control group, resistance exercise training had no significant positive effects on cognitive functioning. For the COPD group, resistance exercise training displayed negative effects on cognitive functioning, contrary to our hypothesis.
Conclusion
While some participants without COPD had minor improvements from resistance exercise, COPD participants had adverse effects from the exercise intervention on cognitive functioning.
Bidirectional Mendelian Randomization analysis of the genetic association between neuromyelitis optica spectrum disorder and cortical structure
Authors: Abudusalamu Rena , Maimaiti Aierpati , tuersun maidina , fang shi , hao chenguang , Han Dengfeng , Ma Jianhua
Published: October 2024

Background
Observational studies have suggested an association between neuromyelitis optica spectrum disorder (NMOSD) and cortical structure, but the results have been inconsistent.
Objective
We used two-sample Mendelian randomization (MR) to assess the bidirectional causal relationship between NMOSD and cortical structure.
Methods
Publicly available research by Karol Estrada et al. provided the NMOSD data, which included 1244 control patients, 132 cases of AQP4-IgG seropositive NMOSD, and 83 cases of AQP4-IgG seronegative NMOSD. ENIGMA Consortium provided genome-wide association study (GWAS) data for cortical surface area (SAw/nw) and thickness (THw/nw) in 51,665 people with European ancestry. For MR, the primary analysis approach employed was the inverse-variance weighted (IVW) method. Sensitivity analyses were used to assess pleiotropy and heterogeneity.
Results
Significant associations were identified between specific cortical regions and NMOSD subtypes. For NMOSD as an outcome, significant results included associations with pericalcarine THw (p = 0.0047,beta =-0.003), pericalcarine THnw (p = 0.0070,beta=-0.002), and superior temporal THw (p = 0.0252,beta = 0.002). For NMOSD as an exposure, significant associations included rostral middle frontal SAw (p = 0.0126,beta = 6.907), rostral middle frontal THw (p = 0.0288, beta =-0.001), and inferior parietal SAw (p = 0.0186, beta = 4.572).
Conclusion
Our findings support a reciprocal causal link between cortical anatomy and NMOSD.Confirming these relationships and clarifying the underlying mechanisms will require more investigation.
Improving rice yield and quality through high-throughput phenomics, linear regression, and machine learning neural network models
Authors: Su Haoran , Wang Yiding , Fu Weimeng , Feng Baohua , Wang Wenting , Chen Tingting , Xu Yongqiang , Xiong Jie , Fu Guanfu , Zeng Yuxiang
Published: October 2024

To explore the potential of using high-throughput plant phenomics in rice breeding programs, one hundred elite rice varieties from southern rice-growing areas in China were subjected to high-throughput phenomic analysis. A total of 88 parameters were measured and obtained using RGB imaging, fluorescence imaging, and hyperspectral imaging at four key rice growth stages: tillering, jointing, grain filling, and 20 days after grain filling. These 88 parameters, which include RGB color and morphological features, chlorophyll fluorescence characteristics, and rice surface reflectance spectra, were analyzed to characterize high yield and high grain quality in rice using subset selection regression and deep learning neural network models. A total of 39 significant linear regression models were obtained for predicting rice yield and grain quality, with R-squared values ranging from 0.86 to 0.15, and an average R-squared of 0.41. The data from the 100 rice varieties were split into training and test sets to evaluate the prediction accuracies of the models using mean absolute error between predicted and actual values. The results indicated that the deep learning neural network model can be used to refine the linear regression model, improving the prediction accuracy. These findings suggest that high-throughput plant phenomics can be effectively utilized in rice breeding programs to select for high-yielding, high-quality rice varieties.
Evaluating the risk of underdiagnosis of invasive breast cancer in needle biopsy-diagnosed ductal carcinoma in situ eligible for radiofrequency ablation
Authors: Shigematsu Hideo , Fujimoto Mutsumi , Suzuki Kanako , Ikejiri Haruka , Amioka Ai , Hiraoka Emiko , Sasada Shinsuke , Arihiro Koji , Okada Morihito
Published: October 2024

Background
Radiofrequency ablation (RFA) is considered a promising alternative to surgical excision for patients with small, unifocal early-stage breast cancer. A significant concern with the application of RFA in patients diagnosed with ductal carcinoma in situ (DCIS) via needle biopsy is the underdiagnosis of invasive cancer. The extent of this underdiagnosis in DCIS patients eligible for RFA has not been clearly defined.
Methods
This retrospective study assessed lesions diagnosed as DCIS via needle biopsy and eligible for RFA at our institution from April 2009 to March 2024. The eligibility criteria for RFA included a lesion size of ≤ 1.5 cm, unifocality, and clinical node negativity. Underdiagnosis was defined as the presence of invasive cancer in surgical specimens. We evaluated the frequency and risk factors associated with underdiagnosis.
Results
During the study period, 606 lesions were diagnosed as DCIS via needle biopsy. Of these, 209 lesions met the criteria for RFA, with underdiagnosis determined in 40 lesions (19.1%). The distribution of pathological T (pT) stages among these lesions was as follows: DCIS in 169 lesions (80.9%), pT1mi in 20 lesions (9.6%), pT1a in 5 lesions (2.4%), pT1b in 9 lesions (4.3%), pT1c in 5 lesions (2.4%), and pT2 in 1 lesion (0.5%). Multivariate logistic regression analysis identified lesion size ≥ 10 mm as a significant risk factor for underdiagnosis (p = 0.016). Adjuvant endocrine therapy and chemotherapy were administered to 26 (65.0%) and 6 (15.0%) of the underdiagnosed lesions, respectively.
Conclusions
Our findings highlight the risk of underdiagnosing invasive breast cancer in patients undergoing RFA for needle biopsy-diagnosed DCIS. It is crucial to acknowledge the potential for undertreatment when considering RFA as a treatment option.
Evaluating the role of whole blood perturbation response in the prognosis of COPD: A bidirectional Mendelian randomization study
Authors: Wang Xue-Qiao , Hu Zhong-Mei , Wang Shi-Guang
Published: October 2024

Purpose
The intricate connection between whole blood disturbance response and COPD was probed using a bidirectional Mendelian randomization approach, thereby broadening the scope of previous observational research findings.
Methods
A comprehensive analysis was conducted on the peripheral blood of more than 4,700 research participants under 37 conditions through the whole blood cell analyzer (Sysmex XN-1000), genotyped more than 2,600 donors, and conducted GWAS on all blood disturbance spectra. The data of COPD are from the FinnGen-public-data(n = 358,369). Utilizing Mendelian randomization analysis as a robust approach to clarify the influence of whole blood disturbance response on the prognosis of COPD and the causal relationship between them.
Results
In the analysis stage, whole blood perturbation response plays a key role in predicting the progress or improvement of COPD. Platelet perturbation response shows the predictive potential of COPD deterioration, while neutrophil, eosinophil and reticulocyte perturbation response show the predictive potential of COPD risk reduction. Furthermore, all heterogeneity analysis further confirmed no presence of heterogeneity among the genetic associations, and the MR-Egger intercept failed to yield any indication of directional pleiotropy in any of these causal relationships.
Hypomagnesemia in Large B cell Lymphoma patients receiving CAR T cell therapy correlates with immune dysregulation and decreased PFS: results from the ZUMA-1 trial and Mayo Clinic cohort
Authors: Gile Jennifer , Mondello Patrizia , Wang Zixing , Li Ying , Bansal Radhika , Gandhi Sangeetha , Zhang Henan , Babadi Elham , Martinez Kodi , McCoy Gabrielle , Shao Zuoyi , Regan Kevin , Hathcock Matthew A. , Wang Panwen , Wang Junwen , Saleh Abdullah S. Al , Ruan Gordon , Ansell Stephen M. , Bennani N. Nora , Johnston Patrick B. , Paludo Jonas , Villasboas-Bisneto Jose C. , Khurana Arushi , Durani Urshila , Wang Yucai , Hampel Paul J. , Rosenthal Allison , Munoz Javier , Moreno Eider , Castro Januario E. , Murthy Hemant S. , Kharfan-Dabaja Mohamed , Kenderian Saad S. , Kim Jenny J. , Shen Rhine , Mattie Mike , Lin Yi , Witzig Thomas E.
Published: October 2024

Background
Hypomagnesemia has been correlated with inferior outcomes in patients with large B cell lymphoma (LBCL) undergoing stem cell transplants. As T-cell and myeloid cell dysfunction have been associated with low magnesium conditions, we investigated whether serum magnesium (Mg) levels could predict clinical outcomes in LBCL patients who received chimeric antigen receptor T-cell therapy.
Methods
Patients with LBCL who received axi-cel under the ZUMA-1 trial or as FDA approved therapy at Mayo Clinic were examined. Serum samples were obtained at specified time points and cytokine analysis was performed. Single cell RNA sequencing was performed on peripheral blood mononuclear cells. The Student T-test, Kruskal Wallis, or Fisher's Exact Tests were used to compare differences in demographics across Mg levels. Survival curves were plotted using the Kaplan-Meier methodology and compared using the Wilcoxon test.
Results
We found that hypomagnesemia before lymphodepletion chemotherapy predicted for inferior progression-free and overall survival in the pivotal study ZUMA-1 (NCT02348216). These results were validated in an independent cohort of LBCL patients receiving axicabtagene ciloleucel (axi-cel) at Mayo Clinic. Hypomagnesemia correlated with increased inflammatory serum markers and cytokine levels including ferritin, IL-6, IL1Ra, IL-8, and MIP1a. scRNAseq analysis unveiled altered immune interactions between monocytes and T cells with a concordant immune suppressive transcriptome.
Conclusions
Hypomagnesemia at the time of CAR-T infusion associates with an unfavorable inflammatory profile and decreased response and survival in LBCL patients receiving axi-cel. These findings suggest a potentially actionable prognostic factor for patients with large cell lymphoma undergoing CAR-T.
Multi-method phenotyping of Long COVID patients using high-dimensional symptom data
Authors: Green* Tessa D. , McWilliams* Christopher , de Figueiredo* Leonardo , Soares Letícia , Pollack Beth , Cohen Allison K. , Zhi-Xuan Tan , Falor Tess , Davis Hannah E.
Published: October 2024

Background
Long COVID, characterized by symptoms that remain or emerge in the months after infection with COVID-19, has complex and highly variable patient presentations, with myriad seemingly disconnected symptoms.
Methods
We apply three different machine learning techniques to identify groups of patients with similar symptoms in a large patient-reported symptom dataset with the aim of identifying robust Long COVID phenotypes.
Results
All three methods produced clinically plausible symptom clusters which are technically valid partitions of the high-dimensional symptom space. However, concordance across methods was low. Some features did recur, such as low-symptom count clusters having the highest average age and lowest proportion of women, and specific recurrent clusters or subclusters across pairs of methods.
Conclusions
The high sensitivity of observed patient clusters to algorithm choice has implications for other studies reporting Long COVID phenotype clustering, as it suggests that a single method may provide an incomplete or unstable partition of the cohort, particularly in studies with fewer symptoms observed. With the 162 reported symptoms considered here, patient presentations vary smoothly and segmentation, while internally consistent, was not reproducible across methods; this suggests that the complexity of LC symptom presentation may easily be missed by clustering approaches that use insufficient data or overly-simplistic clustering methods. Future work would likely benefit from semi-supervised approaches matching patients to pre-defined phenotypes or diagnoses, or from the inclusion of additional patient data. Overall, our multi-method analysis highlights the importance of assessing clustering robustness and considering the full scope of patient symptoms when evaluating treatments.

*Tessa D. Green, Chris McWilliams, and Leonardo de Figueiredo share first authorship.
Survival after cytoreductive radical prostatectomy versus radiotherapy for non-elderly(< 65 years) bone-metastatic prostate cancer (bmPCa) patients: a propensity matched SEER analysis
Authors: Qin Qin , Zhang Qu , Yang Wencui , Liang Gai , Luo Yan , Yuan Mengting , Yao Guojun , Luo Bo , Wu Yemei
Published: October 2024

Background: Prostate cancer (PCa) is one of the most prevalent malignancies in men, with bone metastases significantly impacting survival outcomes. Non-elderly patients (<65 years) with bone-metastatic prostate cancer (bmPCa) represent a unique subgroup with potentially more aggressive disease. This study aims to compare the survival outcomes of cytoreductive radical prostatectomy (cRP) versus radiotherapy (RT) in this patient population using a propensity-matched analysis.
Methods: Data were extracted from the SEER database (2004–2021), focusing on non-elderly bmPCa patients who underwent either cRP or RT. Propensity score matching (PSM) was applied to balance key covariates between the two treatment groups. The primary outcomes were overall mortality (OM) and cancer-specific mortality (CSM), analyzed using Cox proportional hazards models and Kaplan-Meier survival curves.
Results: A total of 3581 patients were included, with 2873 receiving RT and 708 undergoing cRP. After PSM, each group comprised 341 patients. Cox regression analysis revealed that cRP was associated with significantly lower OM (HR 0.69, 95% CI 0.56–0.84, P < 0.001) and CSM (HR 0.62, 95% CI 0.50–0.77, P < 0.001) compared to RT. Subgroup analysis indicated that cRP provided greater survival benefits in patients with lower Gleason scores, lower PSA levels, and N0 staging.
Conclusions: In non-elderly bmPCa patients, cRP offers superior survival outcomes compared to RT, particularly in patients with lower disease burden. These findings suggest that cRP should be considered as a primary treatment option in this cohort, although further prospective studies are warranted to confirm these results.
Keywords: bone-metastatic prostate cancer, cytoreductive radical prostatectomy, radiotherapy, Survival
Diagnostic Performance of Systemic-Immune Inflammation Index for Overall and Complicated Acute Appendicitis: A Systematic Review and Diagnostic Test Accuracy Meta-Analysis
Authors: Montero Javier Arredondo , Delgado-Miguel Carlos , Pérez-Riveros Blanca Paola , Fernández-Atuan Rafael , Rico-Jiménez María
Published: October 2024

Background
This study aimed to analyze the systemic-immune inflammation index (SII) 's diagnostic performance in diagnosing acute appendicitis (AA) and discriminating between complicated acute appendicitis (CAA) and non-complicated acute appendicitis (NCAA).
Methods
This review was registered in PROSPERO (CRD42024587430). We included prospective or retrospective original clinical studies evaluating the diagnostic performance of SII in AA. A search was conducted in PubMed, Web of Science, Scopus, and OVID. Search terms and keywords were: (appendicitis OR appendectomy) AND (systemic-immune inflammation index OR SII). Two independent reviewers selected the articles and extracted relevant data. Methodological quality was assessed using the QUADAS2 index. A synthesis of the results, standardization of the metrics, four random-effect meta-analyses, and two Diagnostic Test Accuracy (DTA) meta-analyses were performed.
Results
Thirteen studies with data from 9083 participants, including 5255 patients with a confirmed diagnosis of AA and 3828 controls (CG), were included in this review. The random-effect meta-analysis of SII (AA vs. CG) included ten articles (3733 AA and 3510 controls) and resulted in a significant mean difference [95% CI] of 1072.46 [750.55,1394.37] (p < 0.001). The random-effect meta-analysis of SII (CAA vs. NCAA) included nine articles (1116 CAA and 2984 NCAA) and resulted in a significant mean difference [95% CI] of 1294.2 [731.54,1856.86] (p < 0.001). Subgroup meta-analysis for studies conducted in pediatric-only populations maintained statistical significance. The DTA meta-analysis (AA vs. CG) yielded a pooled sensitivity and specificity [95% CI] of 81.8 [75.2,86.9] % and 79.9 [68.2,88.1] %. The DTA meta-analysis (NCAA vs. CAA) resulted in a pooled sensitivity and specificity [95% CI] of 72.5 [49.6,87.6] % and 82.5 [65.1,92.2] %.
Conclusions
SII emerges as a robust tool for diagnosing AA and differentiating between NCAA and CAA. The retrospective nature of most of the included studies and their limited geographical distribution warrant further prospective multicenter studies to validate these findings.
Registration: PROSPERO (CRD42024587430).