bluuebunny/crossref_metadata_2025 huggingface dataset:
Construction and transfer of PEI-miRNA-126/210 polyplex into Human Umbilical Vein Endothelial Cells with investigation of its effect on islets survival and function
Authors: Sabet Sarvestani Fatemeh , Tamaddon Ali-Mohammad , Karimi Mohammad-Hosein , Yaghoobi Ramin , Geramizadeh Bita , Heydari Mozhdeh , Al-Abdullah Ismail H. , Azarpira Negar
Published: August 2022

Background:Type 1 diabetes is an autoimmune disorder characterized by the loss of pancreatic islets. Islet allotransplantation is a potentially beneficial therapeutic approach for diabetes. Islets suffer a variety of cellular insults including ischemia and partial vascular loss during isolation, resulting in a significant reduction in viability prior to transplantation. The present study aimed to investigate the effect of angiogenic microRNA (miRNA)-126 and -210 on islet function and viability in an indirect way. Methods:Poly Ethylenimine (PEI)-miRNA-126 and -210 polyplexes were constructed at various Nitrogen/Phosphate (N/P) ratios. After confirmation by gel retardation and ethidium bromide dye exclusion assay, its cytotoxicity and transfection efficiency were analyzed by MTT and fluorescent assays, respectively. After that, the selected polyplexes were used to transfect Human Umbilical Vein Endothelial Cells (HUVECs) in vitro and were indirectly co-cultured with islet cells for three days. Real-time polymerase chain reaction and enzyme-linked immunoassay were conducted to verify the regulation of target genes and the functionality of the islets. Results:The findings showed that PEI could condense miRNAs at N/P=5. The viability of the HUVECs was decreased by increasing the amount of PEI. Additionally, ployplex-126 and -210 led to a decrease in the expressions of target genes, phosphoinositol-3 kinase regulatory subunit 2, sprouty-related EVH1 domain-containing protein 1, and ephrin-A3 in the islets. Moreover, the expressions of Bax and Bcl2 and their ratio in the treated groups by polyplex-126 and -210 led to better survival and function of the islets, with a higher expression of insulin and response to glucose stimulations. Furthermore, polyplex-210 could downregulate the anti-angiogenic protein, thrombospondin 1, compared to the other groups. Finally, the secretion of C-peptide was higher in polyplex-210 than in the other groups, adjusted for insulin secretion. Conclusion:The results indicated that angiogenic miRNAs could promote the survival and function of islet cells by interacting with their targets.
The Effects of Vitamin K2 (Menaquinone-7) on the Leptin and Adiponectin Levels in Overweight/Obese Type 2 Diabetes Patients: A Randomized Clinical Trial
Authors: Adeli Shaghayegh , Pourghassem Gargari Bahram , Karamzad Nahid
Published: August 2022

Background: Type 2 diabetes mellitus (T2DM) is a prevalent disease with metabolic consequences. Lower levels of adiponectin and higher levels of leptin were reported in T2DM. This study aimed to evaluate the effect of menaquinone-7 (MK-7) supplementation on adiponectin and leptin in overweight/obese T2DM patients. Methods: Sixty men and women with T2DM and 27 ≤ body mass index < 35 kg/m2 , participated in this double-blind placebo-controlled randomized clinical trial for 12 weeks. The subjects were allocated into intervention (200 µg/day MK-7) or placebo groups. Three-day food records, anthropometrics and physical activity were assessed and fasting blood samples were collected at the pre- and post-intervention. Serum adiponectin, leptin, fasting blood sugar (FBS) and fasting insulin (FI) were measured and adiponectin to leptin ratio (A/L ratio) was calculated. Results: MK-7 decreased fasting blood sugar (P: 0.018) and fasting insulin (P: 0.012), according to a within group analysis of the 45 patients who finished the research. Fasting blood sugar (P: 0.024) and leptin levels (P: 0.032) were lower in the MK-7 group, but there were no significant changes between the groups in terms of adiponectin or the adiponectin to leptin (A/L) ratio. Conclusion: Current study showed that MK-7 supplementation could lead to significant reduction in leptin and FBS, but it has no effect on the adiponectin and A/L ratio in overweight/ obese T2DM patients.
Biographies of Cleaners in the Thoopukari Novel
Authors: B Annalakshmi
Published: August 2022

Located to tell the biographies of the cleaners. Caste Difference the class differences within the castes can be seen in this period of computerization. There are those who do this work without proper pay and without professional equipment. Cleaners clean the dirty area and make it look dirty to the eyes of others. The denial of a woman's love for being the daughter of a scavenger is a painful one. The story revolves around the life of the people living in Kanyakumari district. Thuppukari's novel focuses on the lives of marginalized sweepers. Poverty alone stands by those who have lost their physical health and their vitality till the end. Cleaners Poverty, class struggle, sentiments are all taken up in this article.
Beliefs in Cho Dharman's Novels
Authors: T Selvanayagam
Published: August 2022

Humanity and belief systems have been found inseparable down the ages. Almost every culture has a unique way of understanding and celebrating its belief systems from birth to death. Though all religious traditions find their origin within human culture and civilization, people generally believe that they obtain God’s blessings for their welfare through their religious rituals and practices. One of those ancient cultures is of those people whom we call “people living in Karisal Mann.” Their life is intertwined with Karisal Man. Cho Dharman’s love and passion for these people is unparalleled. His writings vividly portray the unique characters in their religious cultures and rituals. This essay aims to bring out his idea of belief systems found among “People who live in Karisal Mann.”
THE ANALYSIS OF THE MECHANISMS OF FAMILY BEHAVIOR UNDER FAMILY STRESS CONNECTED WITH A CANCER IN A CHILD
Authors: Гусева М.А. , Цейтлин Г.Я. , Коптева Е.С. , Антонов А.И. , Румянцев А.Г.
Published: August 2022

По данным отечественных и зарубежных исследований, члены семьи в период противоопухолевого лечения ребенка переживают хронический эмоциональный стресс, последствиями которого могут быть существенные трансформации семейного поведения. Цель исследования изучение специфики семейного поведения родителей в стрессогенной ситуации лечения онкологического заболевания у ребенка и анализ факторов, изменяющих структуру диспозиционной регуляции жизнедеятельности семьи. Методом анкетного опроса обследованы 1298 родителей с ребенком, страдающим онкологическим заболеванием в состоянии ремиссии, из 78 регионов РФ. Группа сравнения из исследования Росстата Семья и рождаемость 2009 г. В исследуемой генеральной совокупности отмечены существенные отличия: повышение доли неработающих матерей и доли семей с низким доходом, снижение доли семей, состоящих в незарегистрированном браке. Выявлены особенности репродуктивного поведения: повышенные репродуктивные установки, более высокая детность, трансформация системы ценностей с доминированием ценностей семьи и брака. В статье представлено социологодемографическое объяснение полученным данным, раскрыт поведенческий механизм, повышающий репродуктивные установки, и, тем самым, увеличивающий число рождений в семье

According to domestic and foreign studies, family members during the period of antitumor treatment of a child experience chronic emotional stress, the consequences of which can be significant transformations of family behavior. The purpose of the study is to study the specifics of the family behavior of parents in a stressful situation of cancer treatment in a child and to analyze factors that change the structure of dispositional regulation of family activity. The method of the questionnaire survey examined 1298 parents with a child suffering from an oncological disease in remission from 78 regions of the Russian Federation. The comparison group is from the Rosstat Family and Fertility study in 2009. In the studied population, there were significant differences: an increase in the proportion of nonworking mothers and the proportion of lowincome families, a decrease in the proportion of families in an unregistered marriage. The features of reproductive behavior are revealed: increased reproductive attitudes, higher level of detail, transformation of the value system with the dominance of family and marriage values. The article presents a sociological and demographic explanation of the data obtained, discloses a behavioral mechanism that enhances reproductive attitudes, and thus increases the number of births in a family
EXPERIENCE OF USING AQUALOR PROTECT® SALT SOLUTION FOR THE TREATMENT OF RECURRENT ACUTE RINOSINUSITIS IN CHILDREN
Authors: Гизингер О.А. , Щетинин С.А. , Корнова Н.В.
Published: August 2022

В исследовании приняли участие 62 ребенка в возрасте от 5 до 8 лет, в анамнезе у которых наблюдалось более 5 эпизодов острого риносинусита в год. Целью исследования стало изучение клиникоиммунологической эффективности и безопасности топического применения гипертонического солевого раствора Аквалор Протект в комплексной терапии у детей с рецидивирующим острым риносинуситом. Для достижения цели исследования были сформированы 2 группы: 1 группа состояла из 33 детей, в комплексное лечение которых входил препарат Аквалор Протект, группа 2 (сравнения) состояла из 29 детей. Результаты исследования: комплексная терапия с применением назального спрея Аквалор Протект позволяет сократить сроки лечения, уменьшить количество рецидивов острого риносинусита, функционально восстановить метаболический статус фагоцитов поверхности слизистой оболочки полости носа. Анализ полученных результатов позволяет рекомендовать Аквалор Протект для включения в комплекс лечебнопрофилактических мероприятий у детей с рецитдивирующим острым риносинуситом.

The study involved 62 children aged 5 to 8 years in the history of which more than 5 episodes per year of acute rhinosinusitis. Objective: to study the clinical and immunological efficacy and safety of the topical application of the Aqualor Protect hypertonic saline solution in the treatment of children with recurrent acute rhinosinusitis. To achieve the goal of the study, 2 groups were formed: 1 group consisted of 33 children, the complex treatment of which included the drug Aqualore Protect, group 2 (comparison) consisted of 29 children. Results of the study: complex therapy with the use of Aqualor Protect nasal spray can reduce the time of treatment, reduce the number of relapses of acute rhinosinusitis, and restore the functional metabolic status of phagocytes on the surface of the nasal mucosa. The analysis of the obtained results allows recommending Aqualor Protect to be included in the complex of therapeutic and preventive measures in children with relapsing acute rhinosinusitis
ELABORATION AND IMPLEMENTATION OF INTERNAL APPRAISAL OF EMPLOYEE PERFORMANCE IN HEALTHCARE
Authors: Комиссаров Е.Е.
Published: August 2022

В работе руководителя важно проводить объективную оценку результатов деятельности подчиненных, оценивать уровень их профессиональных знаний и навыков, понимать соответствие работников ожиданиям руководителя и вектору развития организации. В статье рассмотрены преимущества использования внутренней оценки персонала на основе компетенций, описано поэтапное формирование и внедрение этой системы в ГБУЗ Челябинская областная детская клиническая больница.

An important managers task in working with subordinates is an objective assessment of their productivity, level of professional knowledge and skills, as well as compliance of employees with managers expectations and development vector of the organization. The article discusses the advantages of using of the internal appraisal of employee performance, describes the phased establishment and implementation of this system in Chelyabinsk Regional Childrens Clinical Hospital.
ORGANIZATION OF THE CHILDREN'S (PEDIATRIC) DEPARTMENT OF THE EMERGENCY AND PLANNED ADVISORY MEDICAL CARE
Authors: Крашенинников С.Г. , Такшеев Н.Н. , Лапин О.В. , Калинин С.Ю. , Киреева Г.Н.
Published: August 2022

В соответствии с приказом Министерства здравоохранения Челябинской области от 09.09.2016 г. 1517 Об организации оказания экстренной и плановой консультативной медицинской помощи, в целях дальнейшего совершенствования и повышения качества организации и оказания экстренной и плановоконсультативной медицинской помощи с 0 до 17 лет включительно врачами специалистами ГБУЗ Челябинская областная детская клиническая больница (ГБУЗ ЧОДКБ) в медицинских организациях муниципальных образованиях Челябинской области было решено организовать в ГБУЗ ЧОДКБ детское (педиатрическое) отделение экстренной и плановой консультативной медицинской помощи (Д(П)ОЭПКМП). И, в соответствии с приказом главного врача ГБУЗ ЧОДКБ 26.01.2017 г., отделение начало функционировать 2, 3. Следует отметить, что до 01.07.2017 г. вся выездная и консультативная работа координировалась через диспетчерский отдел санитарной авиации областной взрослой больницы. Самостоятельная и полноценная работа Д(П)ОЭПКМП началась с 17.07.2017 г. Диспетчерская служба заработала в круглосуточном режиме независимо от взрослой службы санитарной авиации. Первым руководителем реанимационноконсультативного центра в областной детской больнице был врач анестезиологреаниматолог, заслуженный врач РФ Н.Н. Такшеев. Он возглавлял данное подразделение с 2008 по 2014 гг.. Далее, в период до 2017 г. постоянного руководителя РКЦ не было. С 2017 г. с момента организации Д(П)ОЭПКМП службой руководил врач анестезиологреаниматолог Крашенинников С.Г. С 2019 года отделение возглавил врач анестезиологреаниматолог Калинин С.Ю.
CURRENT ISSUES OF DETERMINING MICROELEMENTS: OPPORTUNITIES OF MODERN LABORATORY
Authors: Гизингер О.А. , Силкина Т.А. , Пешикова М.В.
Published: August 2022

Дефицит микроэлементов, повсеместно регистрируемый среди детей, приводит к задержке физического и нервнопсихического развития, повышает риск возникновения и хронизации различных заболеваний. Длительное отсутствие в рационе некоторых нутриентов или наоборот присутствие их в почве и воде в превышающих нормы количествах может вызывать необратимые изменения в организме. В статье рассматривается физиологическая роль минеральных веществ, макро и микроэлементов, особенности их метаболизма, нормы содержания у детей, основные причины их дефицита в рационе, приводятся рекомендации по выбору материала для исследования микроэлементного состава и возможностях лабораторной диагностики микроэлементозов

Micronutrient deficiency, соmmоnly reсоrded among children leads to stunted physical and mental development, increases the risk of оссurrenсe and сhrоniсity of various diseases. Prolonged absence of some nutrients in the diet оr Viсe versa, the presence of excess amounts in the soil and water can cause irreversible changes in the body. The article deals with the physiоlоgiсal role of minerals, maсrо and microelements, their metabolism, the соntent of children, the main causes of their deficiency in the diet. Recommendations on the choice of material for the study of the microelement composition and the possibilities of laboratory diagnosis of microelementoses are given
GEOGRAPHIC DISTRIBUTION OF PATIENTS WITH ONCOLOGICAL, HEMATOLOGICAL, IMMUNOLOGICAL DISEASES, HOSPITALIZED IN THE NATIONAL SCIENTIFIC MEDICAL CENTER
Authors: Скрипкин А.В. , Ставчанский Р.Ю. , Ишкова Т.А.
Published: August 2022

В статье обсуждается актуальность изучения географического варьирования обращений пациентов за специализированной, высокотехнологичной медицинской помощью в НМИЦ ДГОИ им. Дмитрия Рогачева. Для проведения анализа авторы используют метод графического картирования. Источником данных о случаях обращений пациентов является электронная медицинская база. Полученные данные, позволили выявить наиболее значимые тенденции медикосоциального характера, влияющие на направление детей в ЛРНЦ Русское поле для получения высококвалифицированной реабилитационной помощи. Авторы полагают, что важно повысить информированность врачей и родителей по вопросам реабилитации. Изучение географического распределения, как частотных параметров эпидемиологического процесса, так и реабилитационных программ призвано повысить эффективность оказания медицинской помощи пациентам с онкологическими, гематологическими и иммунологическими заболеваниями

The authors discuss in the article the relevance of studying the geographical variation of patients requests for specialized, hightech medical care at the Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology. For the analysis, the authors use the method of graphical mapping. The source of data on cases of patient visits is the electronic medical database. The obtained data allowed identifying the most significant medical and social trends affecting the referral of children to the Medical and Rehabilitation Scientific Center Russian Field for obtaining highly qualified rehabilitation assistance. The authors believe that it is important to increase the awareness of doctors and parents on rehabilitation issues. The study of the geographical distribution of both the frequency parameters of the epidemiological process and rehabilitation programs is intended to increase the efficiency of medical care for patients with cancer, hematological and immunological diseases
IN HELP TO THE DOCTOR-PEDIATRIC: LABORATORY RESEARCH IN DIAGNOSTICS OF FREQUENTLY MEETED DISEASES (RECOMMENDATIONS OF THE FEDERAL MEDICAL COMPANY "HEMOTEST")
Authors: Силкина Т.А. , Петрова О.Г. , Морозова В.С. , Иванова Т.В. , Бойко Р.З. , Бурова Д.А. , Гизингер О.А.
Published: August 2022

Возможности лабораторной диагностики в педиатрической практике все больше расширяются: внедрение инновационных технологий способствует появлению новых, более качественных методов исследований. В статье рассмотрены наиболее актуальные диагностические направления, для которых предлагаются высокотехнологичные, точные и быстрые в выполнении медицинские тесты

The possibilities of laboratory diagnostics in pediatric practice are expanding more and more: the introduction of innovative technologies contributes to the emergence of new, higherquality research methods. Consider the most current diagnostic areas for which we offer hightech, accurate and fast to perform medical tests
CONGENITAL GENERALIZED MYOPHIBROMATOSIS (CLINICAL CASE)
Authors: Спичак И.И. , Кузина Е.А. , Теплых Е.В.
Published: August 2022

В статье приводится описание клинического случая врожденного генерализованного инфантильного миофиброматоза у новорожденного ребенка. Инфантильный миофиброматоз редко встречающаяся мезенхимальная опухоль мягких тканей у детей, обладающая местным инфильтративным ростом. В ходе обследования данного пациента диагностировались множественные миофибромы, имевшие тенденцию к росту

The article describes the clinical case of congenital generalized infantile myofibromatosis in a newborn child. Infantile myofibromatosis is a rarely occurring mesenchymal soft tissue tumor in children, which has local infiltrative growth. During the examination of this patient, multiple myofibromas, which tended to grow, were diagnosed
Determinan Faktor yang Mempengaruhi Financial Distress Perusahaan Manufaktur Sub Sektor Barang Dan Konsumsi
Authors: Pratama Yodi , Eka Saputra Syailendra , Mulia Pratama Indra , Rahmad Indra
Published: August 2022

The management of companies is acutely aware that to maintain their existence, they must try to avoid increasing the risk of financial distress. This study aims to determine the factors that affect financial distress in manufacturing companies in the food and beverage sub-sector on the Indonesia Stock Exchange. This research was conducted on 33 manufacturing companies in the goods and consumption sub-sector on the Indonesia Stock Exchange. The principal theory used in this study refers to agency theory. Conflicts of interest between principals and agents encourage agents to take advantage of the excess information they have to hide problems occurring within the company. As a result, stakeholders will be harmed, considering the information they receive is irrelevant. In this study, the variables used include financial distress, the proportion of independent commissioners, audit committee size, liquidity, and working capital turnover. This research used the data from 2016 to 2020. The data analysis method used in this study is binary logistic regression. Data processing is conducted by Stata 15. The proportion of the board of commissioners, the number of audit committees, company liquidity, and activity ratios were used in this research. Based on the results of hypothesis testing, it was found that the proportion of independent commissioners had no significant effect on financial distress, while the audit committee, corporate liquidity, and working capital turnover affected financial distress in manufacturing companies in the goods and consumption sub-sector on the Indonesia Stock Exchange.
Bioethical Criticism of Transhumanism Strategies to Eliminate the Vulnerability of the Human Body
Authors:   Catholic Institute of Bioethics, Im Og Ran
Published: August 2022

This paper aims to critique the post-human project of transhumanism that attempts to engineer and artificially evolve the human body by 'removing the vulnerability of the human body' in the post-corona era where 'the vulnerability of the human body' is a problem. First, taking the concept of vulnerability as a starting point, the type and context of vulnerability claimed by transhumanism are identified. Next, transhumanism's reductionist perspective of the human body to attempt engineering evolution is considered. From the point of view of ontological Personalism, the human body is presented as a body with life, a body that acts toward a life purpose and a body that holds human nature. This paper asserts that the human body reveals the human being itself. The scientific, utilitarian, and Enlightenment values embedded in the transhumanism's strategy for eliminating the vulnerability of the body can instrumentalize human life by alienating the human being from the body and reducing human life to the level of usefulness. Rather, This strategy can lead to new vulnerability.
On the contrary, the vulnerability of the human body has a positive aspect, which allows the human being to be more empathetic to others, to complete himself, and to grow with others.
In conclusion, the vulnerability of the human body is not a negative factor that needs to be completely eliminated, but a marker that clearly shows the basis of human dignity and human flourishing.
Nursing Professions and Personalist Bioethics
Authors:   Catholic Institute of Bioethics, Choi Mi Sun
Published: August 2022

The purpose of this study is to examine the relationship between nursing professions and personalist bioethics. This was conducted to prepare basic data for education to expand the nursing ethics, which is the core competency of nursing professions. The relationship between nursing professions and personalist bioethics can be explained in two aspects. The first is a high connection from a philosophical point of view of humans, and the second is that personalist bioethics can present standards to overcome the limitations of the bio-medical ethics principles. The former means that humans should be respected on the premise of dignity in the entire process from the beginning to the end of human life, and that humans are a single existence in which physicality and spirituality are inseparable and beyond the sum of simple parts. In addition, the latter means that the principle of physical life protection that human right to life takes precedence over any other right can provide a standard for ethical decision-making related to human bioethics. In the future, it is proposed to develop, verify, and expand the effectiveness of the personalist bioethics education program so that personalist bioethics can be actively experienced in the field of nursing ethics.
Audiencias virtuales en los procesos laborales y su vigencia en la postpandemia COVID-19
Authors: Salinas Avila Javier Naval
Published: August 2022

La realización de audiencias virtuales en el Perú es producto de una disposición efectuada por el Poder Judicial debido al estado de emergencia nacional provocada por la COVID-19. Se sabe que la finalidad de esta disposición fue la de restablecer el servicio de administración de justicia en el país; sin embargo, estando a puertas de superar la crisis sanitaria, resulta transcendental analizar y evaluar su vigencia, en aras de brindar al justiciable un proceso laboral moderno, apoyado en herramientas tecnológicas y electrónicas, en el marco del fortalecimiento y la consolidación del uso de las tecnologías de información y comunicación en el sistema judicial laboral peruano.
El ne bis in ídem como principio difuminado en la jurisprudencia penal nacional
Authors: Melgar Cucho Jorge Luis
Published: August 2022

Dentro del análisis de la diversidad y multiplicidad de procedimientos y procesos sancionatorios que existen en el Perú, en el caso no tan hipotético de que se haya ventilado un caso o hecho, primero administrativamente, que concluya con una sanción disciplinaria y, a posteriori, en el ámbito penal privativo (castrense), y consecuentemente en el fuero común u ordinario, es factible que, en materia penal, por la existencia de mecanismos procesales de persecución, se sancione a un sujeto que cometió una infracción, y que sea motivo suficiente para que un mismo hecho pueda ser objeto de una regulación sancionadora administrativa y de otra índole penal privativa y penal común u ordinaria. En este escenario, el principio de ne bis in idem es una garantía básica que rodea a todo proceso sancionatorio, y que admite solo una posibilidad de un segundo proceso, a través de una revisión de sentencia, ya que el objetivo de dicho proceso es preservar la necesidad de consolidar un derecho y los principios como el que se ha investigado, a fin de evitar alguna injusticia. Así, pues, a través de este principio se busca lograr que un Estado de derecho disipe la incertidumbre y se sostenga dentro de una seguridad jurídica y respeto por el ciudadano y su dignidad, como base fundamental del mismo Estado y su organización social.
La discriminación de la mujer gestante en su centro laboral: un hecho letal que pasa desapercibido
Authors: Pantoja Rosas Nilton Edwin
Published: August 2022

En el presente artículo, se revisa y analiza el caso de la discriminación laboral que sufre la mujer gestante en su centro laboral por su condición, a pesar de que, según una serie de normativas legales nacionales e internacionales, esta persona debe tener especial protección por parte del Estado y las autoridades. Asimismo, se da cuenta de las razones y consecuencias de este tipo de discriminación.
HUBUNGAN PENGETAHUAN REMAJA PUTRI DENGAN SIKAP DALAM PERAWATAN VULVA HYGIENE DI KELAS X JURUSAN ADMINISTRASI PERKANTORAN SMK IBNU SINA BATAM TAHUN 2020
Authors: Huryah Fadhilatul , Yanti Gea Sri
Published: August 2022

Vulva hygiene merupakan tindakan untuk memelihara kebersihan organ kewanitaan bagian luar ( vulva ) yang di lakukan untuk mempertahankan kesehatan dan mencegah infeksi. Berdasarkan hasil studi pendahuluan dan pada tanggal 3 Agustus 2020 pada remaja putri kelas X jurusan Administrasi Perkantoran SMK Ibnu Sina Batam sebanyak 10 siswi, Peneliti menemukan bahwa 6 remaja putri tersebut kurang mengetahui tentang cara merawat bagian daerah kewanitaan. Sikap dan pengetahuan remaja putri yang kurang tentang vulva hygiene, seperti perilaku yang buruk saat Buang Air Besar (BAB) atau Buang  Air kecil (BAK) membersihkannya dengan air yang tidak bersih dan salah arah saat membersihkannya, memakai celana dalam yang ketat dan tidak menyerap keringat, jarang menganti celana dalam, jarang mengganti pembalut, hal tersebut dapat menjadi pencetus masalah kesehatan reproduksi (Ratna, 2010).  Tujuan dari penelitian ini untuk mengetahui hubungan Pengetahuan Remaja Putri Dengan Sikap Dalam Perawatan Vulva Hygiene di Kelas X Jurusan Administrasi Perkantoran SMK Ibnu Sina Batam Tahun 2020. Jenis penelitian ini merupakan penelitian kuantitatif. Populasi dalam penelitian ini berjumlah 33 siswi dan teknik pengambilan sampel pada penelitian ini menggunakan teknik Total Sampling dengan menggunakan pendekatan Cross Sectional. Variabel dalam penelitian ini terdiri atas dua yaitu variabel bebas ( pengetahuan dan sikap) dengan variabel terikat ( perawatan vulva hygiene ). Penelitian ini menggunakan instrumen dalam bentuk kuesioner. Pengolahan data secara manual dan analisa data distribusi frekuensi dan bivariat menggunakan uji Chi-square. Hasil penelitian menunjukan 93% berpengetahuan baik dan 7 % berpengetahuan kurang dan 85% bersikap baik dan 15 % bersikap kurang. Dari hasil penelitian di dapatkan ada hubungan antara pengetahuan dengan sikap Dalam Perawatan Vulva Hygiene di Kelas X Jurusan Administrasi Perkantoran SMK Ibnu Sina Batam Tahun 2020 dengan hasil p value 0,017 < α 0,05. Dapat disimpulkan bahwa terdapat hubungan pengetahuan dengan dengan sikap Dalam Perawatan Vulva Hygiene di Kelas X Jurusan Administrasi Perkantoran SMK Ibnu Sina Batam Tahun 2020.
HUBUNGAN PENGETAHUAN, SIKAP DAN TINDAKAN POLA ASUH IBU TERHADAP STATUS GIZI BATITA USIA 6-36 BULAN DI POSYANDU KASIH IBU KABUPATEN SOLOK
Authors: Humairah Anugrah
Published: August 2022

Masalah gizi merupakan faktor resiko dasar dari berbagai masalah kesehatan, terutama pada bayi dan anak batita. Keadaan status gizi balita perlu mendapat perhatian khusus terutama oleh ibu. Pengetahuan ibu tentang gizi yang baik tentunya akan membuat status gizi balita baik pula. Sikap ibu dalam pemilihan makanan yang berguna untuk anaknya akan mempengaruhi status gizi balita. Pola asuh ibu dalam kesehatan dan pemberian makanan pada tahun pertama kehidupan sangatlah penting untuk perkembangan batita. Secara umum penelitian ini bertujuan untuk mengetahui hubungan pengetahuan, sikap dan pola asuh ibu dengan status gizi balita Penelitian ini bertujuan untuk mengetahui hubungan pengetahuan, sikap dan tindakan ibu terhadap pola asuh dan dengan status gizi batita usia 6-36 bulan di Posyandu Kasih Ibu Wilayah Kerja Puskesmas Simpang Tanjung Nan Ampek Kabupaten Solok. Penelitian ini bersifat analitik dengan pendekatan Cross sectional study. Pengumpulan data telah dilakukan dengan menggunakan kuisioner kepada 53 orang sampel. Status gizi balita kurus (16,9%), ibu memiliki pengetahuan rendah (50.9 %), ibu memiliki sikap kurang baik (58.5 %), ibu memiliki tindakan kurang baik (58.5 %), terdapat hubungan yang bermakna antara pengetahuan ibu, sikap dan tindakan dengan status gizi batita usia 6-36 bulan di Posyandu Kasih Ibu.

 

Kata kunci : Status Gizi, Pola Asuh, Pengetahuan, Sikap, Tindakan
ANALISIS PEMANFAATAN BINA KELUARGA LANSIA (BKL) OLEH KELUARGA YANG MEMPUNYAI LANSIA GUNA MENCIPTAKAN LANSIA TANGGUH
Authors: Mayasari Eva , Epina Hayu Riska , Sumandar
Published: August 2022

The increasing life expectancy and decreasing death rates have resulted in an increase in the number of elderly people. In Indonesia, the percentage of elderly people has increased, in 2019 it doubled to 9.6 percent where the number of elderly women was one percent more than the number of elderly men (10.10 percent compared to 9.10 percent). Young elderly (60-69 years) reached 63.82 percent, middle elderly (70-79 years) reached 27.68 percent and old elderly (80 years and over) reached 8.50 percent. The purpose of this study was to determine the use of Elderly Family Development (BKL) by families who have elderly. This research is a quantitative research by distributing questionnaires to 310 respondents in the KB Berkah Bersama Village, Bukit Raya District, Pekanbaru City. The results of the evaluation revealed that there was no relationship between the variables of knowledge, attitude, distance and family support on the use of Elderly Family Development (BKL) by families who have elderly
Tratamiento temprano de la mordida abierta anterior. Revisión crítica de la literatura
Authors: Naula-Vicuña Diana Monserrath , Ramírez-Romero Daniel Emanuel
Published: August 2022

El objetivo de este estudio fue efectuar una revisión crítica de la literatura sobre el tratamiento temprano de la mordida abierta anterior. Se hicieron búsquedas de artículos en Medline / PubMed, Scielo. Los artículos de esta revisión señalaron la existencia de variadas opciones de tratamiento temprano aplicados exitosamente para corregir la mordida abierta anterior. En relación al cumplimiento de los criterios Consort y Strobe en los estudios ECCA y transversales; se observó que los artículos mostraron insuficiente información en aspectos relacionados con el diseño de los estudios, resultados, y discusión. Finalmente, mediante el uso de los criterios CONSORT y STROBE utilizados en esta revisión, se encontraron importantes ausencias de información en los reportes de los artículos ECCA y transversales, por lo cual sus resultados y recomendaciones respecto a los tratamientos para mordida abierta anterior deben ser considerados con moderación.
Is FiLaCTM the Ideal Choice for Initial Treatment of Anal Fistula as a Minimally Invasive Treatment Option?
Authors: YÖNDER Hüseyin , TATLI Faik
Published: August 2022

Aim: The laser method (FiLaCTM) has recently emerged as a minimally invasive treatment option in the treatment of anal fistula. Anal incontinence and fistula recurrence after anal fistula surgery are postoperative problems that complicate the treatment. In our study, we aimed to investigate the effectiveness of the film method in the treatment of anal fistula and in which cases it should be preferred in the treatment.
Methods: Twelve patients who underwent FiLaCTM diode laser at Derik State Hospital between July 2017 and August 2018 were included in the study. Patients were analyzed retrospectively in terms of age, gender, development of incontinence, recovery and return to work, fistula types, MRI findings, and complications.
Results: 11 of the patients included in the study were male and 1 female and the mean age was 46. Intraoperative complications were not observed in any of the patients. The mean follow-up period was 13.5 (7-19) months. Complete recovery was observed in 4 (33.3%) patients in the follow-ups of the patients, while no improvement was achieved in 8 (66.7%) patients.
Conclusion: The FiLaCTM procedure for the treatment of anal fistula is a safe, minimally invasive, sphincter-sparing treatment option with low efficacy. However, it can be preferred as an initial treatment in high-level fistulas and in patients who want minimally invasive intervention.
Detección automática, clasificación y reconocimiento de escorpiones mediante técnicas de Aprendizaje Profundo
Authors:   , Giambelluca Francisco Luis
Published: August 2022

La detección e identificación temprana de los escorpiones es esencial debido a la peligrosidad de estos arácnidos que ponen en riesgo la salud de la población, en particular, de los sectores más vulnerables al veneno de un escorpión, como son las personas hipertensas, cardíacas o diabéticas, pero también los niños y los ancianos. A su vez, la detección y clasificación de escorpiones puede ser útil con fines de investigación biológica para estudiar las diferentes variedades de géneros y especies. En este trabajo, con el propósito de brindar herramientas de prevención alternativas, se desarrollaron novedosos sistemas automáticos y en tiempo real para detectar y clasificar escorpiones, utilizando heurísticas de visión artificial y Aprendizaje Profundo, basados en las características de la forma y la propiedad de fluorescencia de los escorpiones cuando son expuesto a luz ultravioleta. En particular, se han investigado las tres especies de escorpiones que se encuentran en la ciudad de La Plata: Bothriurus bonariensis (sin importancia sanitaria), Tityus carrilloi y Tityus confluens (ambas de importancia sanitaria). Durante este trabajo se llevaron a cabo comparaciones entre diferentes modelos basados en Aprendizaje Profundo utilizados para detectar e identificar escorpiones, ya sea por género peligroso o no peligroso, como para determinar su especie dentro de un mismo género. Los resultados satisfactorios obtenidos indican que los sistemas desarrollados pueden, de forma temprana, precisa, no invasiva y segura, detectar y clasificar escorpiones, incluso dentro de un ambiente no controlado, es decir, cuando el escorpión se encuentra cerca de otros objetos que podrían dificultar su detección. Los sistemas de detección y clasificación desarrollados en este trabajo se implementaron como una aplicación móvil, con la ventaja de la portabilidad y la facilidad de acceso a la población, que puede ser utilizada como una herramienta de prevención eficaz para minimizar las picaduras de escorpiones y ayudar a reducir el daño que pueden ocasionar a las poblaciones expuestas a estos arácnidos. Además, estos sistemas son fácilmente escalables a otros géneros y especies de escorpiones para ampliar la región donde se puedan utilizar estas aplicaciones.
Modulación de la contractilidad cardíaca por p38-MAPK: rol del intercambiador Na+/H+ (NHE-1) y del estrés oxidativo
Authors:   , Zavala Maite Raquel
Published: August 2022

El estiramiento miocárdico es un importante estímulo fisiológico que permite al corazón modular su función contráctil y, en consecuencia, adaptar el gasto cardíaco frente a los cambios en las condiciones hemodinámicas. Ha sido demostrado que el estiramiento del mismo induce un aumento de fuerza contráctil en dos fases: una fase rápida debida al mecanismo de Frank-Starling, seguida de una gradual llamada segunda fase de fuerza (SFF). Durante los últimos años, nuestro grupo de trabajo ha aportado sólidas evidencias científicas que demuestran que la SFF en respuesta a cambios de precarga es la expresión de un mecanismo autocrino/paracrino disparado por el estiramiento parietal, que desencadena una compleja ruta de señalización. Ésta vía inicia con la activación del receptor de AT1 de Angiotensina II (Ang II) y del ETA de Endotelina 1, aumento en la producción de especies reactivas del oxígeno (ROS) por parte de la mitocondria y activación de quinasas redox sensibles responsables de activar proteínas de membrana como el intercambiador Na+/H+ (NHE-1). L activación del NHE-1 resulta crucial para el desarrollo de la SFF, ya que su inhibición cancela dicha fase. Al estar activo produce un aumento en la concentración de Na+ intracelular, el cual promueve la activación del funcionamiento del modo reverso del intercambiador Na+/Ca2+ (NCXrev), con el consecuente incremento de Ca2+ intracelular, responsable final del aumento de fuerza de la SFF. Existe evidencia que demuestra que la p38-MAPK regula negativamente la actividad del NHE-1 inducida por Ang II, y que la actividad sostenida de esta quinasa disminuye la contractilidad cardíaca. A su vez, como se mencionó, nuestro grupo demostró que el incremento en la producción ROS inducidas por el estiramiento resulta crucial para el desarrollo de la SFF, debido a que promueven la activación de quinasas redox sensibles responsables de activar al NHE-1, y que, inhibir su producción, cancela el desarrollo de la SFF. En este contexto, el objetivo de este trabajo de Tesis Doctoral fue estudiar el rol de p38-MAPK, así como del estrés oxidativo, sobre la contractilidad miocárdica luego del estiramiento, poniendo especial atención en los posibles efectos sobre la actividad del NHE-1. El presente trabajo ha permitido aportar valiosas evidencias acerca del rol que ejerce la quinasa p38-MAPK sobre la SFF, y a su vez ha contribuido a un mayor entendimiento del papel que juegan las ROS sobre la misma.
The organizational climate and job satisfaction in teachers of a public university
Authors: Ponce Lucas , Ruelas Marco , Flores Ludwing
Published: August 2022

The study determines the relationship between the organizational climate and job satisfaction of teachers at the National University of the Altiplano, Puno (Peru). The deductive method was obtained and the research was of a correlational type, with a non-experimental design and a transactional or transversal type of a single sample cut, whose approach is quantitative. In the methodology, the survey technique was used through the use of a structured questionnaire and for its verification, the statistical tests of Chi square and Spearman's Rho conversion coefficient were used. It will be developed that the organizational climate and job satisfaction will be related in a high positive way, as demonstrated by χ_c^2=26.640, r=0.631. It is concluded that the higher the organizational climate in the teachers of the Universidad Nacional del Altiplano de Puno, the greater personal job satisfaction will be obtained.
Categories of study to consider when analyzing the teaching practice of university teachers
Authors: Martínez Milgian
Published: August 2022

The improvement of teaching demands a constant analysis, reflection and criticism of the practices developed by teachers; in this sense, the objective of this article is to identify which categories should be considered when analyzing the teaching practice of university professors, as well as the aspects that are addressed from the literature when studying the processes of teaching reflection; for this, it is necessary to start from the basis of how people reach knowledge, our thinking structures, the ways in which we learn, how we reflect on our teaching practices, and the models that we create and consolidate to develop our practices. From this context, a review has been made of the approaches of different authors who, since the beginning of the 20th century, have formulated different theories regarding the beliefs, personal epistemology and didactic thinking of teachers, as well as their philosophy, approaches, didactic models and reflection processes, which influence, in one way or another, the practices they develop at the classroom level and, therefore, the way they guide their students. From our experience and based on the literature reviewed, we have identified that, when analyzing the teaching practices of university professors, some categories of thought should be considered, some intrinsic and others extrinsic, among them the beliefs about the didactic task and the context in which the professor develops, as well as his experiences, as indicated by the lifelong learning approach; likewise, the stages that professors go through to develop a reflective practice should be taken into account, starting with unconscious actions to the redefinition and reasoning of the problems.
Pedagogy and didactics of social sciences for early childhood education
Authors: De la Hoz Juan , Hard Edilberto
Published: August 2022

Early childhood education is the stage in which the training process occurs in children from birth to the age of six, it seeks physical, affective, social, and intellectual development, incorporates guidelines for coexistence, based on respect to differences, development of affective capacities, and democratic values that facilitate social interaction. The research that supports this article aims to understand in depth the pedagogical, epistemic, didactic, neuropedagogical, and autodidactic strategies that reorient the teacher's action in the processes of educability and teachability in the area of social sciences and early childhood education. It is approached from an action research - reflection, directed from a comprehensive interpretive method with a bibliographic design. The result is that social thought is enhanced and developed from a pedagogical and didactic praxis pertinent to the nature, essence, and context of the child. It reaches the conclusion of de-instrumentalizing the processes of educability and teachability and placing the human being at the center of the educational process as a multidimensional situated being, that is, a bio-psycho-neurocultural being.
Pedagogía y didáctica de las ciencias sociales para la educación infantil
Authors: De la Hoz Juan , Hard Edilberto
Published: August 2022

La educación infantil es la etapa en que se da el proceso de formación en niños (as) desde el nacimiento hasta la edad de los seis años, busca el desarrollo físico, afectivo, social e intelectual, incorpora pautas de convivencia, sustentadas en el respeto a las diferencias, desarrollo de capacidades afectivas y valores democráticos que faciliten la interacción social. La investigación que fundamenta este artículo, tiene como objetivo comprender a profundidad las estrategias de orden pedagógicas, epistémicas, didácticas, neuropedagógicas y neurodidácticas reorientadoras de la acción del docente en los procesos de educabilidad y enseñabilidad en el área de ciencias sociales y la educación infantil. Se aborda desde una investigación acción – reflexión, direccionada desde un método interpretativo comprensivo con un diseño bibliográfico. Obtiene como resultado que el pensamiento social se potencia y desarrolla desde una praxis pedagógica y didáctica pertinente a la naturaleza, esencia y contexto del niño (a). Llega a la conclusión de desistrumentalizar los procesos de educabilidad y enseñabilidad y poner como centro del proceso educativo al ser humano como un ser situado multidimensional, es decir un ser biopsicosocioneurocultural.
Educational inequality on the northern border of México: social reproduction and violence
Authors: Avila Rocío , Chávez Mónica
Published: August 2022

The persistence of educational actions and mechanisms that increase the exclusion of large groups affect not only school failure and dropout, but also impact low social mobility, an increase social conflicts, and the reproduction of inequality. This statement is contrasted in light of the analysis of indicators of students who completed secondary education in the state of Tamaulipas, Mexico, during 2019 and that illustrates the considerable gap between those who obtained insufficient levels and those who have high academic achievement. The results of the Planea standardized test carried out on 24,532 students were contrasted with socioeconomic, cultural and school modality variables, in addition, the variable of exposure to direct violence was incorporated in order to observe and describe how educational precariousness represents a form of structural violence, which widens the inequality gap, limits mobility and social development. The empirical findings show that there is a significant difference between different school groups, which allows establishing a certain degree of relationship between the context and academic achievement.
Desigualdad educativa en la frontera norte de México: reproducción social y violencia
Authors: Avila Rocío , Chávez Mónica
Published: August 2022

La persistencia de acciones y mecanismos educativos que aumentan la exclusión de grandes colectivos inciden no sólo en el fracaso y abandono escolar, también impactan en una baja movilidad social, un incremento en la conflictividad social, y la reproducción de la desigualdad. Esta afirmación se contrasta a la luz del análisis de indicadores de alumnos que concluyeron la educación secundaria en el estado de Tamaulipas, México, durante 2019 y que ilustra la brecha considerable entre aquellos que obtuvieron niveles insuficientes con quienes tienen alto logro académico. Los resultados de la prueba estandarizada Planea realizada a 24,532 alumnos se contrastaron con variables socioeconómicas, culturales y de modalidad escolar, asimismo se incorporó la variable de exposición a la violencia directa con el objetivo de observar y describir cómo la precariedad educativa representa una forma de violencia estructural, que amplía la brecha de desigualdad, limita la movilidad y el desarrollo social. Los hallazgos empíricos muestran que existe una diferencia significativa entre distintos colectivos escolares, lo que permite establecer cierto grado de relación entre el contexto y el logro académico.