bluuebunny/crossref_metadata_2025 huggingface dataset:
Incidence and frequency of cancer cachexia during chemotherapy for advanced pancreatic ductal adenocarcinoma
Authors: Mitsunaga Shuichi , Kasamatsu Eiji , Machii Koji
Published: February 2020

Purpose

Cachexia influences the patient’s physical wellbeing and quality of life, and the patient’s ability to tolerate their cancer therapies, especially cytotoxic chemotherapy. The purpose of this study was to investigate the frequency and timing of onset of cancer cachexia during chemotherapy and its association with prognosis and toxicity in patients with pancreatic ductal adenocarcinoma (PDAC).

Methods

We performed a retrospective study in patients who underwent first-line chemotherapy after diagnosis of advanced PDAC between 6 June 2008 and 31 March 2017. Base cachexia (weight loss up to 6 months before starting first-line chemotherapy) and follow-up cachexia (after starting first-line chemotherapy) were defined as weight loss > 2% with a body mass index (BMI) < 20 kg/m2 or weight loss > 5%.

Results

A total of 150 patients were registered. The median age and BMI were 65 years and 21.7 kg/m2, respectively. Base cachexia occurred in 50% of patients. Follow-up cachexia occurred in 32% within 12 weeks of starting first-line chemotherapy, reaching 64% at 1 year. Overall survival was not significantly different between patients with and without follow-up cachexia, regardless of whether cancer cachexia occurred within 12, 24, or 48 weeks of starting first-line treatment. Appetite loss, fatigue, nausea, and diarrhea were more frequent in patients with follow-up cachexia than in those without follow-up cachexia.

Conclusion

Follow-up cachexia had an early onset, but was not a prognostic factor for overall survival in patients with PDAC. Some adverse events tended to be more frequent in patients with follow-up cachexia than in those without follow-up cachexia.
Reply to Klocksiem on the Counterfactual Comparative Account of Harm
Authors: Carlson Erik
Published: February 2020

In a recent article in this journal, I claimed that the widely held counterfactual comparative account of harm (CCA) violates two very plausible principles about harm and prudential reasons. Justin Klocksiem argues, in a reply, that CCA is in fact compatible with these principles. In this rejoinder, I shall try to show that Klocksiem’s defense of CCA fails.
General and Specific Considerations as to why Osteoporosis-Related Care Is Often Suboptimal
Authors: Curtis Elizabeth M , Woolford Stephen , Holmes Claire , Cooper Cyrus , Harvey Nicholas C
Published: February 2020

Purpose of Review

The assessment of fracture risk and use of antiosteoporosis medications have increased greatly over the last 20–30 years. However, despite this, osteoporosis care remains suboptimal worldwide. Even in patients who have sustained a fragility fracture, fewer than 20% actually receive appropriate antiosteoporosis therapy in the year following the fracture. There is also evidence that treatment rates have declined substantially in the last 5–10 years, in many countries. The goal of this article is to consider the causes for this decline and consider how this situation could be remedied.

Recent Findings

A number of possible reasons, including the lack of prioritisation of osteoporosis therapy in ageing populations with multimorbidity, disproportionate concerns regarding the rare side effects of anti-resorptives and adverse changes in reimbursement in the USA, have been identified as contributing factors in poor osteoporosis care.

Improved secondary prevention strategies; screening measures (primary prevention) and appropriate, cost-effective guideline and treatment threshold development could support the optimisation of osteoporosis care and prevention of future fractures.
Ternary Pt/Re/SnO2/C catalyst for EOR: Electrocatalytic activity and durability enhancement
Authors: Drzymała Elżbieta , Gruzeł Grzegorz , Depciuch Joanna , Pawlyta Miroslawa , Donten Mikołaj , Parlinska-Wojtan Magdalena
Published: February 2020

Carbon-supported Pt/C, Pt/Re/C, Pt/SnO2/C and Pt/Re/SnO2/C, with 20 wt.% overall metal loading were prepared and their electrochemical activity towards ethanol oxidation reaction (EOR) was investigated. Transmission electron microscopy (TEM) combined with energy dispersive X-ray spectroscopy (EDS) revealed, that indeed binary and ternary combinations of the designed nanoparticles (NPs) were formed and successfully uniformly deposited on a carbon support. Fourier transform infrared spectroscopy (FTIR) allowed to assess the chemical composition of the nanocatalysts and X-ray diffraction (XRD) allowed to determine the catalyst structure. Potentiodynamic and chronoamperometric measurements were used to establish its catalytic activity and stability. The influence of Re addition on the electrochemical activity towards ethanol oxidation reaction (EOR) was verified. Indeed, the addition of Re to the binary Pt/SnO2/C catalyst leads to the formation of ternary Pt/Re/SnO2/C with physical contact between the individual NPs, enhancing the EOR. Furthermore, the onset potential of the synthesized ternary catalyst is shifted to more negative potentials and the current densities and specific activity are nearly 11 and 5 times higher, respectively, than for commercial Pt catalyst. Additionally ternary Pt/Re/SnO2/C catalyst retained 96% of its electrochemical surface area.
Potentially pathogenic bacteria isolated from diverse habitats in Spitsbergen, Svalbard
Authors: Mogrovejo-Arias Diana C. , Brill Florian H. H. , Wagner Dirk
Published: February 2020

The Arctic ecosystem, a reservoir of genetic microbial diversity, represents a virtually unlimited source of microorganisms that could interact with human beings. Despite continuous exploration of Arctic habitats and description of their microbial communities, bacterial phenotypes commonly associated with pathogenicity, such as hemolytic activity, have rarely been reported. In this study, samples of snow, fresh and marine water, soil, and sediment from several habitats in the Arctic archipelago of Svalbard were collected during Summer, 2017. Bacterial isolates were obtained after incubation on oligotrophic media at different temperatures and their hemolytic potential was assessed on sheep blood agar plates. Partial (α) or true (β) hemolysis was observed in 32 out of 78 bacterial species. Genes expressing cytolytic compounds, such as hemolysins, likely increase the general fitness of the producing microorganisms and confer a competitive advantage over the availability of nutrients in natural habitats. In environmental species, the nutrient-acquisition function of these compounds presumably precedes their function as toxins for mammalian erythrocytes. However, in the light of global warming, the presence of hemolytic bacteria in Arctic environments highlights the possible risks associated with these microorganisms in the event of habitat melting/destruction, ecosystem transition, and re-colonization.
Behandeling van prostaatkanker bij mannen met een somatische of BRCA-kiembaanmutatie
Authors: Mehra Niven
Published: February 2020

Samenvatting

Er zijn nieuwe inzichten in een subgroep van prostaatkankerpatiënten met veranderingen in de breast cancer susceptibility genes BRCA1/2. BRCA1/2 zijn eiwitten met een belangrijke rol in DNA-schadeherstel en zijn betrokken bij het foutloos herstel van dubbelstrengs DNA-breuken. De BRCA2-mutatiestatus blijkt met name relevant bij het ontstaan en de progressie van prostaatkanker. Prostaatkankerpatiënten met een somatische of BRCA2-kiembaanmutatie, hebben bij de diagnose een slechter stadium, en hebben een agressiever ziektebeloop. BRCA-mutatiestatus is tevens relevant als predictieve biomarker. Bij patiënten met een castratieresistent prostaatcarcinoom en een BRCA1/2-variant in de tumor is er een belangrijke rol weggelegd voor poly (ADP-ribose) polymerase (PARP) remmers. Medio 2020 wordt de registratie van de eerste PARP-remmer voor deze indicatie verwacht. Kennis van de BRCA-mutatiestatus heeft – naast belangrijke therapeutische consequenties voor de patiënt – ook eventuele implicaties voor zijn familie wanneer het om een BRCA-kiembaanmutatie blijkt te gaan. DNA-onderzoek zal veelvuldiger worden toegepast voor optimale risico-inschatting en persoonsgerichte behandeling van zowel patiënten met gelokaliseerd als gemetastaseerd prostaatkanker.
Geospatial Artificial Intelligence: Potentials of Machine Learning for 3D Point Clouds and Geospatial Digital Twins
Authors: Döllner Jürgen
Published: February 2020

Artificial intelligence (AI) is changing fundamentally the way how IT solutions are implemented and operated across all application domains, including the geospatial domain. This contribution outlines AI-based techniques for 3D point clouds and geospatial digital twins as generic components of geospatial AI. First, we briefly reflect on the term “AI” and outline technology developments needed to apply AI to IT solutions, seen from a software engineering perspective. Next, we characterize 3D point clouds as key category of geodata and their role for creating the basis for geospatial digital twins; we explain the feasibility of machine learning (ML) and deep learning (DL) approaches for 3D point clouds. In particular, we argue that 3D point clouds can be seen as a corpus with similar properties as natural language corpora and formulate a “Naturalness Hypothesis” for 3D point clouds. In the main part, we introduce a workflow for interpreting 3D point clouds based on ML/DL approaches that derive domain-specific and application-specific semantics for 3D point clouds without having to create explicit spatial 3D models or explicit rule sets. Finally, examples are shown how ML/DL enables us to efficiently build and maintain base data for geospatial digital twins such as virtual 3D city models, indoor models, or building information models.
Hühnerlaus
Authors: Borgards Roland
Published: February 2020

Tiere erlauben einen ertragreichen Zugriff auf Büchners literarisches Werk. Exemplarisch zeigt sich dies an der »Hühnerlaus« aus dem Woyzeck. Ein Animal Reading dieses Tieres entfaltet zunächst vor dem wissensgeschichtlichen Hintergrund der Parasitenforschung die Rätselhaftigkeit von Büchners literarischer Hühnerlaus und schlägt dann vier mögliche Perspektiven vor, wie diese Rätselhaftigkeit für eine Interpretation fruchtbar gemacht werden kann: einen editionsphilologischen Lesartenstreit, die Debatten um den Wissenshorizont des Autors und seiner Figuren, eine Verortung in der Geschichte der Biotheorie sowie die Frage nach einer Tier-Ästhetik der Groteske.
Extinction of North AmericanCuvieronius(Mammalia: Proboscidea: Gomphotheriidae) driven by dietary resource competition with sympatric mammoths and mastodons
Authors: Smith Gregory James , DeSantis Larisa R. G.
Published: February 2020

The gomphotheres were a diverse and widespread group of proboscideans occupying Eurasia, North America, and South America throughout the Neogene. Their decline was temporally and spatially heterogeneous, and the gomphotheres ultimately became extinct during the late Pleistocene; however, the genusCuvieroniusis rarely represented in late Pleistocene assemblages in North America. Two alternative hypotheses have been invoked to explain this phenomenon: (1) competitive exclusion by sympatric mammoths and mastodons or (2) ecologic displacement due to an environmental transition from closed forests to open grasslands. To test whether competition for resources contributed to the demise of North AmericanCuvieronius, we present herein a large collection of stable isotope and dental microwear data from populations occupying their Pleistocene refugium in the Atlantic Coastal Plain. Results suggest thatCuvieroniusconsumed a wide range of resources with variable textural and photosynthetic properties and was not specialized on either grasses or browse. Further, we document evidence for the consumption of similar foods between contemporaneous gomphotheres, mammoths, and mastodons. The generalist feeding strategy of the gomphotheres likely facilitated their high Miocene abundance and diversity. However, this “jack of all trades and master of none” feeding strategy may have proved challenging following the arrival of mammoths and likely contributed to the extirpation ofCuvieroniusin North America.
Within-person, between-person and seasonal variance in nutrient intakes among 4- to 8-year-old rural Zambian children
Authors: Caswell Bess L. , Talegawkar Sameera A. , Siamusantu Ward , West Keith P. , Palmer Amanda C.
Published: February 2020

Estimates of the components of nutrient intake variation are needed for modelling distributions of usual intake or predicting the usual intake of individuals. Season is a potential source of variation in nutrient intakes in addition to within- and between-person variation, particularly in low- or middle-income countries. We aimed to describe seasonal variation in nutrient intakes and estimate within-person, between-person and other major components of intake variance among Zambian children. Children from rural villages and peri-urban towns in Mkushi District, Zambia aged 4–8 years were enrolled in the non-intervened arm of a randomised controlled trial of pro-vitamin A carotenoid biofortified maize (n 200). Up to seven 24-h dietary recalls per child were obtained at monthly intervals over a 6-month period covering the late post-harvest (August–October), early lean (November–January) and late lean (February–April) seasons (2012–2013). Nutrient intakes varied significantly by season. For energy and most nutrients, intakes were highest in the early lean season and lower in the late post-harvest and late lean seasons. Season and recall on a market day had the strongest effects on nutrient intakes among covariates examined. Unadjusted within- to between-person variance ratios ranged from 4·5 to 31·3. In components of variance models, season accounted for 3–20 % of nutrient intake variance. Particularly in rural settings in low- and middle-income countries, where availability of locally grown, nutrient-rich foods may vary seasonally, studies should include replicates across seasons to more precisely estimate long-term usual intakes.
Brown manuring optimization in maize: impacts on weeds, crop productivity and profitability
Authors: Das T. K. , Ghosh S. , Nath C. P.
Published: February 2020

Field experiments were carried out in order to investigate if brown manuring (BM) usingSesbaniaplants can be used to control weeds in maize, especiallyCyperus rotundus(Experiment I), and further to optimize the BM technology through appropriateSesbaniaseed rate (S), 2,4-D application time (T) and dose (D) (Experiment II). Each BM treatment received a pre-emergence application of pendimethalin 1.0 kg a.i./ha. Experiment I showed that the BM practice using 15 kg/haSesbaniaseed and 2,4-D 0.50 kg a.i./ha applied at 25 DAS led to better control of weeds, especiallyC. rotundusand higher maize grain yield. Further optimization studies (Experiment II) indicated that among the factors S, T and D, the BM combination S~25 kg/ha, D~0.50 kg a.i./ha and T~25 DAS (i.e. S25T25D0.50) resulted in lowest weed density (3.1/m2) and dry weight (3.8 g/m2) and highest weed control index (89.2%) at 60 days after sowing (DAS) which was at par with another BM practice S15T25D0.50. However, the later BM combination led to significantly higher maize productivity (5.25 t/ha) and profitability (net returns (NR) $878/ha), which were 103 and 280% higher, respectively, than the weedy check (WC). TheSesbaniaseed rate S~15 kg/ha gave 7% higher maize grain yield and 12% higher NR than its corresponding level S~25 kg/ha. Therefore,SesbaniaBM with 15 kg seeds/ha and 2,4-D at 0.50 kg a.i/ha applied at 25 DAS can be recommended for effective and eco-friendly weed management in maize, which would provide higher maize grain yield and enhance farmers' profitability.
Inter-individual differences in the nutrition response: from research to recommendations
Authors: Cecil Joanne E. , Barton Karen L.
Published: February 2020

The 2019 Nutrition Society Spring Conference, which convened in Dundee, focused on the challenges presented by inter-individual differences in the responses to nutrition and in conducting nutritional research. The programme brought together national and international experts to discuss the collective evidence on inter-individual nutritional responses and impacts on health. Speakers and delegates from across the UK, Europe and the USA debated new methods of conducting research in nutrition and discussed the development of appropriate dietary interventions to maintain health and prevent disease in diverse populations. Symposium 1 focused on the effects of ethnicity on nutrient availability and type 2 diabetes and cardio-metabolic disease. Symposium 2 explored sex differences in nutrient availability and health and metabolism. The final symposium examined genetic and phenotypic variation, nutrition and health. The meeting ended with a panel discussion about how we take research to recommendations and concluded with a need to consider inter-individual differences in planning, conducting and analysing nutritional research.
Seroepidemiology of dengue and chikungunya fever in patients with rash and fever in Iran, 2017
Authors: Tavakoli Forough , Rezaei Farhad , Shafiei-Jandaghi Nazanin Zahra , Shadab Azadeh , Mokhtari-Azad Talat
Published: February 2020

After the mass campaign of Measles and Rubella vaccination in 2003 in Iran, the cases of measles and rubella infection decreased but still, the cases of rash and fever were reported. It is worth noting that some other viral infections show signs similar to measles and rubella such as some arboviruses. Considering the epidemic outbreak of arbovirus infections in countries neighbouring Iran, we performed this study to estimate the possibility of chikungunya and dengue fever among measles and rubella IgM negative patients presenting with rash and fever from December 2016 to November 2017 in the National Measles Laboratory at Tehran University of Medical Sciences. Serum samples were selected at random from patients from eight provinces. The presence of DENV IgM and CHIKV IgM was examined by enzyme-linked immunosorbent assay. Of the 1306 sera tested, 210 were CHIKV seropositive and 82 were dengue seropositive. Statistical analysis demonstrated a significant increase in the CHIKV IgM antibody seropositivity rate in Kerman (OR = 2.07, 95% CI: 1.10–3.92;P= 0.024) and Fars (OR = 1.77, 95% CI: 1.06–2.93;P= 0.027). The DENV and CHIKV seropositivity rate in summer is higher than in other seasons (P< 0.01). Our seropositive samples suggest possible CHIKV and DENV infection in Iran. It is likely that these viruses are circulating in Iran and there is a need to study vector carriage of these two viruses.
C-reactive protein and albumin kinetics before community-acquired bloodstream infections – a Danish population-based cohort study
Authors: Garvik O. S. , Póvoa P. , Magnussen B. , Vinholt P. J. , Pedersen C. , Jensen T. G. , Kolmos H. J. , Lassen A. T. , Gradel K. O.
Published: February 2020

Early changes in biomarker levels probably occur before bloodstream infection (BSI) is diagnosed. However, this issue has not been fully addressed. We aimed at evaluating the kinetics of C-reactive protein (CRP) and plasma albumin (PA) in the 30 days before community-acquired (CA) BSI diagnosis. From a population-based BSI database we identified 658 patients with at least one measurement of CRP or PA from day −30 (D–30) through day −1 (D–1) before the day of CA-BSI (D0) and a measurement of the same biomarker at D0 or D1. Amongst these, 502 had both CRP and PA measurements which fitted these criteria. CRP and PA concentrations began to change inversely some days before CA-BSI diagnosis, CRP increasing by day −3.1 and PA decreasing by day −1.3. From D–30 to D–4, CRP kinetics (expressed as slopes – rate of concentration change per day) was −1.5 mg/l/day. From D–3 to D1, the CRP slope increased to 36.3 mg/l/day. For albumin, the slope between D–30 to D–2 was 0.1 g/l/day and changed to −1.8 g/l/day between D–1 and D1. We showed that biomarker levels begin to change some days before the CA-BSI diagnosis, CRP 3.1 days and PA 1.3 days before.
Phylogeography of the rare Australian endemic Grey Falcon Falco hypoleucos: implications for conservation
Authors: MULLIN DALE W. , MCCULLOCH GRAHAM A. , SCHOENJAHN JONNY , WALTER GIMME H.
Published: February 2020

The Grey Falcon Falco hypoleucos is one of the world’s rarest raptors, with an estimated population size of fewer than 1,000 individuals. Our knowledge of threats posed to the Grey Falcon remains scant. Understanding the genetic variation in this species would help to assess its conservation status more realistically and its prospects for survival in a changing environment. We amplified the cytochrome b region of mitochondrial DNA from the feathers of 26 individuals captured from the wild across the distribution of the species and assessed the genetic diversity and spatial genetic structuring of the species. Genetic diversity was low, with only six haplotypes identified, but there was no evidence of a recent genetic bottleneck. No population genetic structuring was detected, indicating that the Grey Falcon population is effectively continuous across the species’ entire distribution, covering much of Australia’s arid/semi-arid zone. Our results indicate that the Grey Falcon should be managed as a single population and suggest conservation efforts that benefit the species at a local level should be good for the species as a whole. Future studies should employ next generation sequencing approaches, which may provide finer-scale information on the extent these birds move among breeding sites. Further research into the species’ ecology is also required to identify effective conservation measures.
Individualization of attention-deficit/hyperactivity disorder treatment: pharmacotherapy considerations by age and co-occurring conditions
Authors: Mattingly Greg W. , Wilson Joshua , Ugarte Leticia , Glaser Paul
Published: February 2020

Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder that manifests in childhood and can persist into adolescence and adulthood. Impairments associated with ADHD can impact quality of life, social interactions, and increase the risk of morbidity and mortality; however, for many patients, effective treatment can lessen these effects. Pharmacotherapy with stimulants or nonstimulants is recommended in conjunction with psychosocial therapy for most patients. Determining the optimal pharmacotherapy can be complex, and the clinician needs to consider many factors such as the patient’s age, comorbidities, and lifestyle. Furthermore, the needs of the patient with ADHD will change over time, with specific challenges to consider at each stage of life. A variety of Food and Drug Administration (FDA)-approved stimulant and nonstimulant formulations are available with different modes of delivery and durations of effect. This armamentarium of ADHD medications can be used to individualize ADHD treatment for each patient’s needs. This article combines current information from the literature and the first-hand experience of the authors to provide guidance on ADHD treatment options for patients of different ages and for some of the more common comorbidities.
The Impact of Sleep on the Relationship between Soccer Heading Exposure and Neuropsychological Function in College-Age Soccer Players
Authors: Levitch Cara F. , McConathey Eric , Aghvinian Maral , Himmelstein Mark , Lipton Michael L. , Zimmerman Molly E.
Published: February 2020

Objective:

Soccer is the most popular sport worldwide and is the only sport where athletes purposely use their head to deflect the ball during play, termed “heading” the ball. These repetitive head impacts (RHI) are associated with worse neuropsychological function; however, factors that can increase risk of injury following exposure to such head impacts have been largely unexamined. The present study provided a novel examination of the modifying role of sleep on the relationship between RHI exposure and neuropsychological function in college-age soccer players.

Methods:

Fifty varsity and intramural college soccer players completed questionnaires assessing recent and long-term heading exposure, a self-report measure of sleep function, and a battery of neuropsychological tests.

Results:

A high level of recent heading exposure was significantly associated with poorer processing speed, independent of concussion history. With reduced sleep duration, a high level of recent heading exposure was related to worse sustained attention. However, with greater hours of sleep duration, heading exposure was related to preserved neuropsychological outcome in sustained attention.

Conclusions:

We replicated our earlier finding of an association between recent head impact exposure and worse processing speed in an independent sample. In addition, we found that sleep may serve as a risk or protective factor for soccer players following extensive exposure to head impacts. Ultimately, this study furthers the understanding of factors impacting neuropsychological function in soccer players and provides empirical support for sleep interventions to help ensure safer soccer play and recovery from injury.
Support interventions for families of people with terminal cancer in palliative care
Authors: Areia Neide P. , Góngora José N. , Major Sofia , Oliveira Vivianne D. , Relvas Ana P.
Published: February 2020

Objective

The terminal phase of cancer represents a major crisis for the family system. Regardless of the caregiving role they undertake, family members are forced to address multiple impacts when facing the approaching death of their terminally ill loved one. International guidelines recognize the importance of integrating the family into a care plan. However, more needs to be known about how to deliver optimal family support. The purpose of this study is to review the current state of the art in family/caregiver-focused interventions of people with terminal cancer in palliative care.

Method

For this purpose, an overview of the literature's systematic reviews on the topic was conducted to select Randomized Controlled Trials (RCTs) on family/caregiver-focused interventions.

Results

Nine interventions were found in the systematic reviews of literature and meta-analysis. These family/caregiver-focused interventions were then thoroughly and critically analyzed. Despite the heterogeneity with regard to their characteristics, the interventions commonly focused on caregiving matters, were brief in duration, and delivered by non-mental health experts. The efficacy of such interventions was seen as modest.

Significance of results

Family/caregiver-focused interventions in palliative care remain a matter of concern and more research is needed to identify adequate and effective ways of helping families that face the crisis of terminal illness in the system.
Bookends to a Gentler Capitalism: Complicating the Notion of First and Second Gilded Ages
Authors: Greene Julie
Published: February 2020

The narrative of a second Gilded Age erroneously suggests that the current dynamics are repeating those of the late nineteenth century. Although they share certain important characteristics, these are profoundly different historical moments. Focusing on the history of capitalism and labor, and taking a global perspective, demonstrates that the two periods were bookends—the “before” and “after” to a lengthy period when the cruelest characteristics of corporate capitalism were temporarily constrained. The late nineteenth century saw the ascent of serious efforts to rein in the power of the new capitalism and force it to bow down to the needs of civil society. During the late twentieth and early twenty-first centuries, we are experiencing the decline of that effort as capitalists and their ideological and political supporters push to see how far they can go to ensure the unchallenged hegemony of corporate and property rights. The slow climb toward a more humane capitalism and the rapid descent away from it constitute two very different experiences.
CONTAINING THE RAINBOW COALITION
Authors: Haynie Kerry L.
Published: February 2020

The emergence of an African American and Latino-dominated coalition with the potential to reconfigure American government and politics at the national, state, and local levels is one of the most noteworthy developments in U.S. politics over the past two decades. Racialized mass incarceration and felon disenfranchisement are impediments to this coalition’s political power. Social scientists, legal scholars, and activists have long paid attention to how devices like poll taxes, English competency tests, voter intimidation, racial gerrymandering, and voter identification laws restrict participation and diluted the political influence of racial and ethnic minorities. This essay seeks to direct renewed scholarly attention to racialized mass incarceration and felon disenfranchisement as similar devices for suppressing and containing minority group political power.
THE COMMUNITY IN CRIMINAL JUSTICE
Authors: Bell Monica C.
Published: February 2020

This article sets forth four modalities of the relationship between members of marginalized communities and the criminal justice system:subordination, consumption, resistance, and transformation. These modalities attempt to break out of traditional ways of thinking about community members’ formal roles in the system—defendants, witnesses, victims, judges, prosecutors, police officers, correctional officers, and the indeterminate but oft-invoked “community.” Instead, these modalities are fluid and situational. This article also calls for new research, scholarship, and advocacy that takes seriously how members of communities that the criminal legal system most deeply and directly affects engage in these fluid and situational modalities. Attention to the complexity of “community” is essential to creating lasting change in social systems of blame and punishment.
THE LATIN OF THEPASSIONES MARTYRVMOF LATE ANTIQUE ROME
Authors: Lapidge Michael
Published: February 2020

A substantial number ofpassiones(some forty) of Roman martyrs was composed at Rome and its environs between the early fifth and late seventh century (c. 425 –c. 675). Although these texts have hitherto been neglected by students of the Latin language (not least because they are only available in early printed editions dating from the fifteenth to seventeenth centuries, none of which are easily accessible), they provide a valuable witness to changes in the language during that period, when, as a reflex of developments in the spoken language and of deterioration in educational standards, written Latin began to exhibit a rightward shift of verb satellites (change to VO-order in main clauses, placement of the infinitive after the modal auxiliary, placement of the dependent genitive after its noun etc.), as well as a number of associated linguistic features. These changes are illustrated by statistical analyses, the results of which are presented in accompanying tables.
Do South African Xhosa-Speaking People with Schizophrenia Really Fare	Better?
Authors: Niehaus Dana , Jordaan Esme , Laubscher Riana , Sutherland Taryn , Koen Liezl , Potocnik Felix
Published: February 2020

Abstract. Objectives: Results from multinational WHO studies suggest that schizophrenia patients in developing countries may have more favorable prognoses and morbidity outcomes than those in developed settings. This study serves to establish whether mortality outcomes in South African Xhosa-speaking schizophrenia patients are more favorable than in the general South African population. Methods: We recruited a group of 981 patients from September 1997 to March 2005 as part of a genetic study in the Western, Southern, and Eastern Cape provinces of South Africa. For this substudy, participants were included when they reached the age of 60 years during the study period (8–15 years). We examined factors associated with the probability of dying and computed survival times using national census data as reference. Results: At the time of follow-up, 73 individuals were 60 years or older (21.9% could not be traced); some 40% of the sample had died at the time of the follow-up assessment (mean age at death = 60.12 years, SD = 4.97). Univariate survival analysis, using duration of disorder, revealed that the number of hospitalizations and psychotic episodes impacted survival time. Compared to the age-specific death rates of the general South African population, the death rate in the Xhosa-speaking schizophrenia sample was higher than expected in the 60–69 years category, but lower than expected in the 70+ years category. Conclusion: This study suggests that increased exposure to inpatient mental healthcare (expressed as number of hospitalizations) at baseline, and number of psychotic episodes, improve survival probability in a group of older South African Xhosa-speaking schizophrenia patients.
Interpersonal Focus in the Emotional Autobiographical Memories of	Older and Younger Adults
Authors: Polsinelli Angelina J. , Rentscher Kelly E. , Glisky Elizabeth L. , Moseley Suzanne A. , Mehl Matthias R.
Published: February 2020

Abstract. The present study examined the interpersonal focus within autobiographical memories (AMs) of older and younger adults from the perspective of socioemotional selectivity theory (SST). Specifically, we measured interpersonal focus directly through rater codings (relational vs. individual focus) and social word use, and indirectly through personal pronoun use. Forty-five older ( Mage = 76.76) and 25 younger ( Mage = 18.64) adults recalled positive and negative AMs, which were then coded and processed through computerized text analysis software to obtain word-use counts. Consistent with SST, the positive AMs of older adults were more interpersonally focused compared to negative AMs and younger adults. The results suggest that the positive life experiences of older adults tend to be associated with a high degree of social importance and focus on others.
Sensitivity of Tropical Cyclone Formation to Resolution‐Dependent and Independent Tracking Schemes in High‐Resolution Climate Model Simulations
Authors: Raavi Pavan Harika , Walsh K.J.E.
Published: February 2020

In the present study, global tropical cyclone (TC) formation characteristics are estimated using two fundamentally different Commonwealth Scientific and Industrial Research Organisation (CSIRO) and Okubo‐Weiss zeta parameter (OWZP) tracking schemes in the reanalysis data and in a high‐resolution climate model with interannually varying sea surface temperatures. Both the schemes have a reasonable global geographical distribution of TC genesis locations with under simulation in the eastern North Atlantic and northwestern Australian regions. The mean annual TC frequency in the model is similar to observations using the CSIRO scheme but higher using the OWZP scheme, whereas the annual frequency in reanalysis using the OWZP scheme is similar to observations but halved using the CSIRO scheme. In the CSIRO scheme, both the resolution‐dependent thresholds and large‐scale climate may play a role for skilful TC formation statistics. In contrast, large‐scale climate leads to changes in OWZP TC detections. This highlights the importance of the large‐scale environment for TC detections in both the tracking schemes. The OWZP scheme can differentiate the monsoon lows from the actual TCs in the north Indian Ocean compared to the CSIRO scheme, which incorrectly detects them as TCs in the monsoon season. The distribution of TC lifetime in the model using the OWZP scheme is similar to observations. Conversely, the CSIRO scheme detected TCs have shorter lifetimes, perhaps due to intrinsic tracking scheme differences. Although the tracking schemes are fundamentally different, the study shows that there exist some similarities between them and for certain TC formation characteristics the OWZP scheme performs better compared to the CSIRO scheme.
Is Low‐Temperature Fission‐Track Annealing in Apatite a Thermally Controlled Process?
Authors: Tamer Murat , Ketcham Richard
Published: February 2020

We report a new series of experiments to explore the phenomenon of low‐temperature annealing of fission tracks in apatite that feature a number of improvements over previous work. Grain mounts were preirradiated using 252Cf to increase confined track detection and allow briefer thermal neutron irradiation. We coirradiated and etched four apatite varieties (Durango, Fish Canyon, Renfrew, and Tioga) over five time steps equally spaced from 3.66 to 15 ln(s). A length standard was coetched with all experiments to ensure that subtle differences are within detection limits. Finally, we used a standard etching protocol, allowing the data to be comodeled with extensive high‐temperature data sets and recent analyses of induced tracks that underwent ambient‐temperature annealing over year‐to‐decade time scales. Ambient‐temperature annealing occurs at two different rates, with faster annealing at early stages that decreases to a slower rate that converges with empirical fanning linear or curvilinear models. The nature of this decrease varies among the apatite species examined, but no patterns could be determined. The fitted models make geological time‐scale predictions consistent with those based on high‐temperature data only and also make predictions consistent with reasonable inferred low‐temperature histories for all four apatite varieties. The empirical fanning curvilinear equation encompasses low‐temperature annealing at month‐to‐decade time scales, but low‐temperature annealing at shorter time scales may occur by a distinct mechanism. We consider but rule out annealing by radiation from short‐lived activated isotopes. We also reconsider the notion of the initial track length, and the appropriate length for normalizing confined track length measurements.
Prioritizing Water Security in the Management of Vector‐Borne Diseases: Lessons From Oaxaca, Mexico
Authors: Akanda Ali S. , Johnson Kristin , Ginsberg Howard S. , Couret Jannelle
Published: February 2020

Changes in human water use, along with temperature and rainfall patterns, are facilitating habitat spread and distribution of Aedes aegypti and Aedes albopictus mosquitoes, the primary vectors for the transmission of Dengue, Chikungunya, and Zika viruses in the Americas. Artificial containers and wet spots provide major sources of mosquito larval habitat in residential areas. Mosquito abatement and control strategies remain the most effective public health interventions for minimizing the impact of these vector‐borne diseases. Understanding how water insecurity is conducive to the establishment and elimination of endemic mosquito populations, particularly in arid or semiarid regions, is a vital component in shaping these intervention strategies.
On the Confinement of Ultrarelativistic Electron Remnant Belts to Low Shells
Authors: Pinto V. A. , Zhang X.‐J. , Mourenas D. , Bortnik J. , Artemyev A. V. , Lyons L. R. , Moya P. S.
Published: February 2020

Ultrarelativistic electron remnant belts are frequently observed at low
shells between the inner belt and a re‐forming outer belt following geomagnetic disturbances that led to a dropout of electron fluxes at higher radial distances from the Earth. Using wave, particle, and plasma measurements from the Van Allen Probes and Pc3‐Pc5 ultra low frequency (ULF) wave data from ground magnetometers from September 2012 to November 2017, we find significant correlations between the upper edge of the remnant belts and the minimum plasmapause and last closed drift shell locations. The maximum 2‐hr‐averaged radial diffusion rate based on ULF wave power recorded during the dropouts is correlated with the upper edge of the remnant belts and last closed drift shell position. Frequently, ULF wave power is sufficiently strong down to the upper edge of the remnant belts to allow a fast outward radial diffusion of electrons up to the last closed drift shell and to account for the observed confinement of remnant belts to low
shells. The electron phase space density often exhibits the needed negative or oscillating outward gradients in the region of flux loss. Accordingly, fast outward radial diffusion by ULF waves turns out to be a crucial contributor to the depletion of the outer belt that leads to the formation of remnant belts of ultrarelativistic electrons, although we show that multi‐MeV electron precipitation through combined scattering by contemporaneous electromagnetic ion cyclotron (EMIC) and lower‐band chorus waves probably contributes in a limited number of cases.
Three‐Dimensional Electrical Resistivity Structure Beneath a Volcanically and Seismically Active Island, Kyushu, Southwest Japan Arc
Authors: Hata M. , Munekane H. , Utada H. , Kagiyama T.
Published: February 2020

To understand the subduction dynamics around Kyushu Island, Southwest Japan Arc, the distribution of fluids is imaged by resolving three‐dimensional (3‐D) electrical resistivity structure beneath a subregion the island, including volcanic and nonvolcanic areas. The nonvolcanic region in central Kyushu is situated between two regions with numerous Quaternary volcanic structures along a volcanic front aligned N30°E and related to subduction of the Philippine Sea Plate. Two source areas of slow slip events lie at depths of 20–40 km along the eastern coast of Kyushu, whereas earthquakes spread along the subducting Philippine Sea Plate plane over the eastern coast and toward the volcanic front at depths of 20 to >100 km. Our 3‐D resistivity model detects prominent conductors, indicating the presence of fluids, which might control volcanic and seismic activity. The most robust features of the model are three regions of high conductivity. A magma system and a fluid system are imaged as two vertical conductors extending from a depth of ~70 km, both related to slab‐derived fluid and located along the volcanic front, beneath the volcanic and nonvolcanic regions, respectively. The third conductor, which suggests the presence of slab‐derived fluid and hydrated sediments at the plate interface and the presence of serpentinite in the mantle wedge, appears in an area devoid of slow slip events at depths of <~30 km along the southeastern coast.
Time‐Dependent Heat Budget of a Thrust from Geological Records and Numerical Experiments
Authors: Maino Matteo , Casini Leonardo , Boschi Chiara , Di Giulio Andrea , Setti Massimo , Seno Silvio
Published: February 2020

We present thermometric measurements and numerical simulations of the thermal budget of a shallow thrust (5–7 km of depth). We determine the temperatures of synkinematic minerals by chlorite geothermometer and illite crystallinity index and sheared veins with stable isotope and fluid inclusion microthemometry. The fault zone attained temperature higher than the wall rocks (ΔT of ~50 °C). Some heavily damaged rocks retain a minor but systematic record of a further temperature increase up to 150 °C, and the isotopic signal of fluids indicates a proximal source localized close to the fault zone. We simulated the geological evolution with a suite of elasto‐visco‐plastic thermomechanical models using a 2‐D finite difference code that reproduces the stress, strain, temperature, and pressure variations occurring within the thrust zone. Results indicate that shear heating during distributed cataclastic flow can account for a moderate and persistent temperature increment (ΔT 5–30 °C). Transient higher temperature pulses (50–90 °C) are reproduced simulating coseismic slip along narrow fault planes localized within the broad cataclastic zone. Integration of analytical data and numerical results supports the slow creeping frictional‐viscous deformation as effective mechanism explaining the low‐T part of the thermal history. Seismic deformation equivalent to moment magnitude Mw > 6.5–7.0 earthquakes is required to fully account for the thermal signal, including the extreme peak temperature.
Reduced‐Dimensional Gaussian Process Machine Learning for Groundwater Allocation Planning Using Swarm Theory
Authors: Siade Adam J. , Cui Tao , Karelse Robert N. , Hampton Clive
Published: February 2020

Groundwater management and allocation planning involves a rigorous assessment of the performance of operational decisions such as extraction/injection rates on community and environmental objectives. Maximizing performance through numerical optimization can be essential for high‐value resources and is often computationally infeasible due to long simulation model run times combined with nonconvex objectives and constraints. In order to mitigate these drawbacks, surrogate models can be used in place of complex models during the optimization process. There exist a number of machine learning techniques that can be used to develop a data‐driven surrogate model. However, the curse of dimensionality, common to groundwater management, limits the use of these techniques due to the necessity for large training data sets. Even though it is now possible to handle large data sets, the generation of these data sets themselves remains computationally prohibitive as they require numerous simulations to produce accurate surrogates. In this study, we integrate a dimensionality reduction method using truncated singular value decomposition to reduce the number of decision variables, thereby reducing the size of the training data set needed. Correspondingly, we demonstrate a simple technique for acquiring an approximate minimax Latin Hypercube design from within the subspace. We also implement a novel technique for adaptive resampling through particle swarm optimization in order to maintain accuracy of the surrogate model throughout the optimization process. The resulting accurate surrogate model for the Perth regional aquifer system of Western Australia runs in a matter of seconds. Adopting this approach can produce timely solutions, making formal optimization tractable for practitioners.
A comprehensive non-redundant gene catalog reveals extensive within-community intraspecies diversity in the human vagina
Authors: Ma Bing , France Michael T. , Crabtree Jonathan , Holm Johanna B. , Humphrys Michael S. , Brotman Rebecca M. , Ravel Jacques
Published: February 2020

Analysis of metagenomic and metatranscriptomic data is complicated and typically requires extensive computational resources. Leveraging a curated reference database of genes encoded by members of the target microbiome can make these analyses more tractable. In this study, we assemble a comprehensive human vaginal non-redundant gene catalog (VIRGO) that includes 0.95 million non-redundant genes. The gene catalog is functionally and taxonomically annotated. We also construct a vaginal orthologous groups (VOG) from VIRGO. The gene-centric design of VIRGO and VOG provides an easily accessible tool to comprehensively characterize the structure and function of vaginal metagenome and metatranscriptome datasets. To highlight the utility of VIRGO, we analyze 1,507 additional vaginal metagenomes, and identify a high degree of intraspecies diversity within and across vaginal microbiota. VIRGO offers a convenient reference database and toolkit that will facilitate a more in-depth understanding of the role of vaginal microorganisms in women’s health and reproductive outcomes.