bluuebunny/crossref_metadata_2025 huggingface dataset:
The Effect of Topical Nitroglycerin on Wound Healing in Rabbits using Histopathological Investigation
Authors: Moshaveri Arman , Babazadeh Daryoush , Modarresi-Ghazani Faezeh , Hejazi Veghar , Saeed Muhammad , Ahmadi Simab Pouria
Published: June 2023

Introduction: Nitroglycerin can increase the Cycle Guanosine Mono Phosphate level, enhance nitric oxide rate in tissues dilate vessels, and intensify perfusion within tissues. The aim of the present study was to conduct a microscopic investigation addressing the effect of topical 2% Nitroglycerin ointment on wound healing in rabbits.

Materials and methods: Six adult male New Zealand white rabbits, weighing approximately 2.25 kg were used. Two wounds were created on each side of the spinal column. The wounds reached the deep fascia and their dimensions were 15  15 mm. The left wound was used as the control and the right wound was used as the experimental one. Immediately after the creation of wounds, a layer of nitroglycerin 2% with 1 mm thickness was put on the experimental wound daily for seven days. On days 3, 5, 7, and 14 after cutting, both the experimental and control wounds with a margin of healthy tissues were taken for the histopathological examination.

Results: The distance of the two edges on the wound in treated wounds reached a significant difference, compared with control wounds on day 14. The number of inflammatory cells (with neutrophils format) in the treatment group was significantly less than those of the control group starting from day 5. In addition, the fibrin clot diameter in the treatment group was significantly less than the control group on days 5, 7, and 14. At the beginning of the experiment angiogenesis in the control group was more than in the treatment group, but it was the same in both groups on day 7, and angiogenesis in the treatment group was more than in the control group after day 7. The volume of granulation in the treatment group was more than control group and there was a significant difference on days 5, 7, and 14. Epithelial tissues diameter was higher in the treatment group and the difference became significant on day 14.

Conclusion: In conclusion, the findings indicated a promising function of topical NTG in wound healing of anal fissures, tendinopathies, CNH, diabetic foot, or skin flap necrosis.
Nghiên cứu thực nghiệm sấy tiêu bằng máy sấy năng lượng mặt trời
Authors: Nguyễn Hữu Hòa , Bùi Ngọc Hùng , Nguyễn Hải Đăng
Published: June 2023

Một mô hình máy sấy sử dụng năng lượng mặt trời kết hợp gia nhiệt bằng điện trở đã được thiết kế và chế tạo để sấy tiêu với năng suất 5 kg/mẻ. Kết quả khảo nghiệm cho thấy thời gian sấy tiêu tỷ lệ nghịch với vận tốc tác nhân sấy và tỷ lệ thuận với bề dày lớp vật liệu sấy. Thời gian sấy tiêu là từ 7 - 9 giờ khi sấy tiêu từ ẩm độ 64 ± 1% (cơ sở ướt) xuống 13 ± 1% (cơ sở ướt) ở nhiệt độ tác nhân sấy 600C, với các mức vận tốc tác nhân sấy từ 1,0 đến 1,5 m/s và bề dày lớp vật liệu sấy từ 13 đến 40 mm. Sản phẩm tiêu có màu đen, da nhăn nheo, mùi nồng đặc trưng và đảm bảo vệ sinh an toàn thực phẩm. Sản phẩm tiêu khi sấy bằng máy sấy không bị nhiễm khuẩn Escherichia coli.
Pemanfaatan Teknologi Informasi Dalam Pembelajaran Daring Pada Masa Pandemi Covid-19 Di Kampung Holtekamp
Authors: Pieter Marla Sheilamita Shalin , Novianti Andi Gita , Manullang Evanita V
Published: June 2023

Pandemi COVID-19 pada awal tahun 2020 memberikan dampak yang sangat besar di berbagai sektor di seluruh dunia. Sektor pendidikan sangat terlihat pergeserannya, dimana biasanya siswa/siswi yang melakukan pembelajaran di Sekolah, namun karena pandemic harus melakukan pembelajaran dari rumah. Kampung Holtekamp adalah salah satu kampung di pinggir kota yang masih termasuk dalam wilayah administrasi ibu kota Provinsi Papua yaitu Kota Jayapura. Proses pembelajaran tidak dilakukan secara online karena berbagai factor, yakni keterbatasan fasilitas dan pengetahuan tentang teknologi. Oleh karena itu kegiatan pengabdian yang dilakukan adalah memberikan pelatihan kepada siswa/siswi Sekolah Dasar dan Menengah untuk memanfaatkan teknologi sehingga dapat menggunakan fasilitas seperti handphone dan jaringan internet untuk membantu proses pembelajaran. Setelah kegiatan pengabdian dilakukan ada peningkatan pemahaman dan kemampuan siswa/siswi dalam memanfaatkan teknologi untuk membantu proses pembelajaran. Siswa/siswi juga mampu menggunakan berbagai aplikasi yang diperkenalkan seperti zoom, google meet, pics art dan tiktok untuk mengerjakan tugas-tugas yang diberikan dari sekolah.

 

Kata kunci:Pandemi COVID-19, Pembelajaran Daring, Kampung Holtekamp.
In-vitro and in-silico evaluation of Brugmansia sauveolens' ability to treat asthma
Authors: Nandy Shouvik , Thakur Shikha
Published: June 2023

Asthma is a common chronic inflammatory disease of the airways. The airway epithelium produces bioactive cellular mediators that trigger the chronic inflammatory response. These mediators then attract and activate inflammatory cells in the airways of the lungs and release more biochemical mediators. With several benefits, such as a significant reduction in the cost and time of drug discovery as well as the use of laboratory animals, in-silico studies have grown to be an important and simple method for examining various chemical compounds against various targets. One of the common herbs found in the local Himalayan area is Brugmansia sauveolens, known as Datura, which is a source of tropane alkaloids and asthma can be effectively managed with alkaloids. Using a Soxhlet extractor, the collected plant components were first extracted with petroleum ether (to remove fats) followed by methanol. Online technologies like PASS Online, Molinspiration, SEA, SWISS, and SLAP data were used for a variety of in-silico predictions. After that, we tested the ability of Brugmansia extracts to reduce inflammation using an in-vitro approach. Rat RBC membrane lyses were stabilized using the plant extract fractions. The outcomes were also compared with aspirin (a common anti-inflammatory drug). Bioinformatics techniques were used to detect structural activity. After investigating all the data It was shown that B. sauveolens had anti-asthmatic activity.
Biblische Namen in Phraseologismen
Authors: Nazarov Kambaraly , Mirzakarimov Mahmudjon
Published: June 2023

Die vergleichende Analyse der biblischen Phraseologismen des Deutschen, Englischen und Russischen hat uns gezeigt, dass die biblischen deonymischen Phraseologismen in verschiedenen Sprachen - ungeachtet vieler individueller Besonderheiten auf der Ausdrucksebene - auf der Inhaltsebene durch verschiedene Ähnlichkeiten charakterisiert sind. Man kann daraus wohl schlussfolgern, dass die biblischen Namen zu den beständigen und produktiven Bestandteilen des phraeologischen Systems in den verglichenen drei indoeuropäischen Sprachen gehören.
Sustentabilidade na prática
Authors: Ohi Ana Gabriela Kolde , Ganiko-Dutra Matheus
Published: June 2023

A Educação CTSA (Ciência, Tecnologia, Sociedade e Ambiente) propõe um ensino no qual os alunos sejam capazes de participar das tomadas de decisão envolvendo os assuntos relacionados. Essa abordagem é influenciada pelas vertentes da Educação Ambiental (EA), as quais, por sua vez, estão relacionadas aos modelos de sustentabilidade vigentes. Neste estágio supervisionado, realizado em formato de pesquisa, investigou-se a relação de uma escola pública do interior do estado de São Paulo com os modelos de sustentabilidade. Foram realizadas observações das aulas, da escola em si e análise dos livros da biblioteca. Foi possível identificar a adoção dos Modelos Padrão de Desenvolvimento Sustentável e Neocapitalista por parte da escola, os quais estão relacionados à corrente de EA chamada vertente de sustentabilidade. Constatou-se que o conhecimento do professor a respeito dos diversos aspectos de EA permite a escolha das vertentes que mais se aproximam da proposta CTSA.
Soberania e violência biopolítica neoliberal
Authors: Yazbek Andre
Published: June 2023

O presente artigo recupera as noções de “guerra de raças” e de “biopoder” na série lições ministradas por Michel Foucault no Collège de France, intituladas Il faut défendre la Société (1976), para refletir sobre a relação entre neoliberalismo e violência política. Nesse sentido, gostaria de examinar como o pensamento de Foucault formulou o problema do biopoder vinculado ao problema da violência e da raça para analisar nossa atualidade política (neo)liberal em termos de paradigmas raciais e coloniais.
Réflexions sur la priorisation de l’accès aux soins pendant l’épidémie de Covid
Authors: Sabot Philippe Sabot
Published: June 2023

Dans l’article présent j’essaie de mettre en perspective quelques-uns des enjeux saillants de la crise sanitaire de Covid-19, notamment sa dimension biopolitique en face des défis bioéthiques. En partant, donc, d’une problématique singulière, celle de la priorisation des patients dans l’accès aux soins, notamment aux soins intensifs, qui permettent d’approfondir la réflexion concernant le traitement des vies humaines à l’articulation d’une préoccupation pour la vie biologique à l’échelle d’une population (sauver des vies) et d’une attention d’ordre éthique au vécu de la maladie, par les soignants, les patients ou par leurs proches, en particulier lorsque les ressources médicales manquent pour faire face aux demandes de soins.
Transgressão, resistência, subjetividade e arte em Foucault
Authors: Pavini Renan , Cicotte Luiz Guilherme Nunes
Published: June 2023

A temática da arte atravessa o pensamento de Michel Foucault em pelo menos dois momentos. Na década de 1960, em que Foucault é influenciado por autores como Blanchot, Bataille e Mallarmé e o problema da arte é posto como uma alternativa crítica aos saberes e a subjetividade é colocada em questão através das noções de transgressão, de limite e do ser da linguagem. Na década de 1980, em que o filósofo compreende a arte moderna como resistência, pois a partir de seu estilo de vida Outro, aquilo que Foucault chamou de vida artista, traz uma existência escandalosa e a marca da coragem da verdade, numa revivescência do cinismo antigo. Partindo dessa distinção, o presente artigo busca pensar como a arte, em cada um desses períodos, encontra-se colocada de maneira diversa no pensamento de Foucault, principalmente a partir da problemática da subjetividade.
ABELMOSCHUS ESCULENTUS ADVERSE EFFECT ON THE SPLENIC CYTO-ARCHITECTURAL AND MORPHOLOGICAL INTEGRITY OF MALE WISTAR RATS
Authors: Okesina A.A , Obeten K.E , Eko J , Adekilekun H.A , Lawal A.K
Published: June 2023

Background: Abelmoschus esculentus herbaceous hairy annual plant of the mallow family is widely consumed globally. High consumption of this plant may compromise the immune system, if it affects the functions of the spleen, whereas, the spleen is the main filter for blood-borne pathogens and antigens, as well as a key organ for iron metabolism and erythrocyte homeostasis. Objective: Our study was aimed at determining the possible toxicological effects of Abelmoscus esculentuson on the spleen of adult Wistar rats. Methods: Twenty-one (21) adult Wistar rats weighing about 150-170g were used for this study and were divided into three (3) groups of 7 animals each (n=7). Groups (I-III) received; normal rat feed and water, a low dose of Abelmoschus esculentus 1.0mg/kg BW and a high dose of Abelmoschus esculentus 3.0mg/kg BW respectively. All extracts were given daily by the oral gavage method for fourteen (14) days. Twenty-four hours after the last administration, the animals were sacrificed by cervical dislocation. The spleen was harvested, weighed, and fixed in 10% buffer formalin, sectioned, and processed for microscopic studies. Results: Following the administration of Abelmoschus esculentus, there was a significant increase in the test group. Also, histological observation showed Abelmoschus esculentus could result in various grades of degenerative changes, while prolonged intake at high concentrations may cause adverse effects on the cells of the spleen which may alter the functionality of the spleen. Conclusion: Hence, herbal remedies may help improve organ health, but can cause serious side effects if taken inappropriately.
ANALGESIC ACTIVITY OF METHANOL LEAF EXTRACT OF MOMORDICA FOETIDA (SCHUMACH) IN ALBINO RATS
Authors: Nyiramugisha D , Odoma S
Published: June 2023

Background Momordica foetida is been used traditionally in the management of several diseases including pain. However, there is no scientific evidence to validate its efficacy. Objective The aim of this study, therefore, is to investigate the analgesic activity of its methanol leaf extract. Methods The oral median lethal dose (LD50) in albino rats was determined using Lorke’s method. The tail immersion in hot water and formalin-induced tests in albino rats were used to evaluate its analgesic activity at 250, 500, and 1,000 mg/kg, doses and tramadol was employed as the standard analgesic agent. Results The LD50 value of the plant extract was found to be greater than 5,000 mg/kg. The plant produced a significant (p<0.01) pain latency at the 1,000 mg/kg dose at time 150 minutes as compared to the control group. However, the lower doses (500 and 250 mg/kg) failed to significantly increase the pain latency time. The pain due to formalin was also significantly (p<0.05 and p<0.01) inhibited by the 1,000 mg/kg dose of the extract in both phases of formalininduced pain. Meanwhile, the lower doses (250 and 500 mg/kg) were only effective in the second phase (p<0.05). Conclusion Based on the findings, it was concluded that the present study has demonstrated the analgesic potential of methanol leaf extract of Momordica foetida in experimental animals and thus validates the folkloric use of the plant in the management of pain and related conditions. The plant is also safe when taken orally.
ÖĞRENME KAYIPLARIYLA AİLENİN EĞİTİM DÜZEYİ VE EKONOMİK OLANAKLARI ARASINDAKİ İLİŞKİ
Authors: AHISKA Harun , YÖRÜK Seyit , DOĞAN Fehmi
Published: June 2023

ÖZET

Dünya Sağlık Örgütü’nün COVİD-19 salgınını 2020 yılının Mart ayında pandemi olarak ilan etmesinin hemen ardından ülkemizde yüz yüze eğitime ara verilmiştir. Milli Eğitim Bakanlığı 23 Mart 2020 tarihi itibariyle, eğitim öğretim faaliyetlerinin uzaktan eğitim yöntemiyle devam edeceğini açıklamıştır. Milli Eğitim Bakanlığı, öğretmen ve öğrencilere online destek sağlamak amacıyla kurduğu Eğitim Bilişim Ağı (EBA) üzerinde güncelleme yaparak canlı ders modülünü kullanıma açmıştır. Aynı şekilde Türkiye Radyo Televizyon Kurumu (TRT) ile ortaklaşa çalışarak sadece öğrencilere yönelik ders anlatımının yapıldığı, kültürel, sanatsal ve sportif programların yer aldığı TV kanalları kurmuştur. Bilindiği gibi yüzyüze eğitime doğal afetler, hastalıklar ve uzun tatiller gibi çeşitli sebeplerle zaman zaman verilen aralar öğrencilerin öğrenme kayıpları yaşanmasına yol açmaktadır. Bu araştırma ebeveynlerin eğitim düzeyi arttıkça çocuklara sağlanan akademik katkının daha yüksek olduğu, aynı şekilde ebeveynlerin ekonomik olanakları arttıkça çocuklarına ayırabileceği daha fazla zaman ve ekonomik desteklerle çocuklarının uzaktan eğitim sistemlerine daha kolay adapte olduğu, ancak eğitim seviyesi ve ekonomik olanakları düşük seviyede yer alan ailelerin çocuklarının ise öğrenme kayıpları açısından dezavantajlı bir duruma düştüklerini ortaya koymaktadır. Bu açıdan Milli Eğitim Bakanlığı, fırsat ve imkân eşitliği sağlayabilmek için çalışmalar yapmalıdır. Bu çalışmada örneklem üzerinden COVID-19 pandemisi esnasında ülkemizde ders bazında öğrenme kayıpları tespit edilerek, öğrenme kayıplarının oluşmasında ebeveynlerin eğitim düzeyi ve ekonomik olanakları arasındaki ilişki incelenmiştir. Ebeveynlerin eğitim düzeyi ve ekonomik olanaklarının arttıkça öğrencilerin eğitime erişim ve öğrenme performanslarının arttığı görülmüştür.
Pengaruh Penggunaan Media Pembelajaran ICT terhadap Hasil Belajar IPA Kelas V di SD Lanraki II Makassar
Authors: Mulyadi Mulyadi , Nur Syam  , Fitriyani Yahya
Published: June 2023

Abstract: The Effect of Using ICT Learning Media on Class V Science Learning Outcomes at Sd Lanraki I  I Makassar.  This study aims to determine  the influence of the use of ICT learning media on the learning outcomes of science class V at SD Lanraki II Makassar.  The approach to this study uses experimentalresearch used to determine the successful use of ICT Learning media. The population of this study was all grade V students of SD Lanraki II, while the study sample was 17 people. Data collection is carried out by observation, learning outcomes tests and documentation. The data collected in the study were analyzed using descriptive and inferential statistical techniques. Based on the results of data analysis, it can be seen that the results of the school environment questionnaire of 2180 and the results of the character building questionnaire of 2227 can be seen that the results of ICT-based learning affect the science learning outcomes of grade IV students of SD Inpres Lanraki 2 Makassar City. Judging from the results of the paired sample t-test, the significance value was obtained by 0.000< 0.05.
Peranan Guru dan Orang Tua dalam Mengembangkan Sosial Emosional Anak
Authors: Abd. Hakim Naba  , Nirwana Nirwana
Published: June 2023

Abstract: The Role of Teachers and Parents in Developing Children's Social Emotional.  This study aims to describe the role of teachers and parents in developing children's social and emotional development and describe supporting and inhibiting factors in developing children's social and emotional. This research approach uses a qualitative approach using descriptive qualitative research. The location of the study was carried out by group B Mekka at Tk Islam Al-abrar Makassar City. The data sources in the study were sourced from primary data and skunder data. The data collection techniques in this study are using observation methods, interviews, and documentation methods. The results of this study show that teachers play a very important role in developing children's social and emotional. There is the role of the teacher as an educator, meneger, supervisor, communicator, and motivator. The role of parents in developing children's social and emotional is to instill an attitude of courtesy, foster a sense of responsibility, teach children to always do good, get used to a disciplined life, understand a child's feelings. There are factors that can support and hinder the child's social emotional development. Supporting and inhibiting factors in the child's social emotional development are physical factors, psychological factors and environmental factors of self-confidence..
IMPORTÂNCIA DO GOVERNO ELETRÔNICO E DA UTILIZAÇÃO DE TECNOLOGIAS DA INFORMAÇÃO E COMUNICAÇÃO NO FORTALECIMENTO DA SEGURANÇA PÚBLICA E NO COMBATE AOS CRIMES DE FRONTEIRA
Authors: Braga Higor , Becker Jefferson
Published: June 2023

A nova realidade gerada pela sociedade do conhecimento, que utiliza massivamente ferramentas tecnológicas como smartphones, tablets e notebooks para buscar informações, trouxe a necessidade de criação de estruturas governamentais com foco voltado para implementação de políticas relacionadas ao Governo Eletrônico. O objetivo deste trabalho é compreender como a implementação de ferramentas de tecnologia da informação e comunicação podem aproximar a relação Estado x sociedade e contribuir para um fortalecimento da segurança pública, aumentando a efetividade das ações de enfrentamento aos crimes de fronteira. Para isso, foi realizada uma revisão bibliográfica sobre o tema, concluindo-se que, apesar de existirem várias ações pontuais e efetivas promovidas pelas diversas instituições integrantes da segurança pública, ainda existe uma carência em relação a políticas públicas com abrangência nacional e que promovam a real integração dos dados e universalização das ações, gerando resultados mais satisfatórios e automaticamente interferindo na relação entre Estado x sociedade.
ESTUDO SOBRE SEGURANÇA VIÁRIA DE AMBIENTE URBANO EM DESENVOLVIMENTO
Authors: Schneider Ricardo
Published: June 2023

O objetivo central do presente trabalho foi demonstrar que no processo de planejamento e implantação de uma obra viária nem sempre consegue-se prever todas as situações oriundas do processo de desenvolvimento das regiões urbanas e que impactam sobre o desempenho da via. Constatou-se que tornam inerentes ao processo de instalação da obra o acompanhamento constante para identificação das possíveis mudanças necessárias a manutenção da segurança do tráfego. No estudo de caso da rodovia analisada, as mudanças tiveram um impacto direto no número de sinistros, que foram reduzidos de 47 acidentes no biênio anterior a implantação das mudanças, para 16 no biênio seguinte.
ANÁLISE DA IMPLANTAÇÃO DO PROGRAMA BRIGADAS ESCOLARES – DEFESA CIVIL NA ESCOLA, NO MUNICÍPIO DE CASCAVEL/PR
Authors: Cardoso Tiago Alves , Faria Nilson Rosa
Published: June 2023

As edificações escolares exigem uma atenção especial em relação aos riscos relacionados à ocorrência de incêndios e às situações de pânico, visto que apresentam o agravante de comportar uma população composta, predominantemente, por crianças, as quais, em sua grande maioria, não sabem o que fazer e para onde se direcionar em caso de incêndio. Nesse cenário, a rede pública municipal de ensino de Cascavel/PR atende crianças, na faixa etária de 0 a 10 anos, e conta com 118 unidades, consistindo em 63 escolas e 55 Centros Municipais de Educação Infantil (CMEIs), sendo que, no ano de 2016, mais de 86% não possuíam condições de segurança, em conformidade com o Código de Segurança Contra Incêndio e Pânico do Corpo de Bombeiros Militar do Paraná. Este estudo visa, por meio de um estudo de caso, descritivo e de natureza aplicada, com uma abordagem quantitativa, a analisar os resultados alcançados, decorridos os cinco anos da implantação do Programa Brigadas Escolares – Defesa Civil, na escola no município de Cascavel/PR. A parceria entre o Corpo de Bombeiros Militar do Paraná e a Secretaria Municipal de Educação proporcionou a formação de 1572 brigadistas, adequação gradual e progressiva das instituições, com as medidas mínimas de segurança, e a obtenção de Certificado de Vistoria do Corpo de Bombeiros (CVCB) em 101 unidades, ou seja quase 86% da totalidade, destacando-se o aprimoramento da segurança nos CMEIs, dos quais mais de 96% passaram a possuir licença emitida pelo Corpo de Bombeiros. O Programa viabilizou não somente a obtenção da documentação de autorização de funcionamento das unidades, mas, principalmente, oportunizou a conscientização e a capacitação da comunidade escolar para ações preventivas e de enfrentamento às situações de incêndio e pânico.
Pendidikan karakter dalam mewujudkan sumber daya manusia berdaya saing menuju Indonesia Emas 2045
Authors: Sudarma Unang
Published: June 2023

Artikel ini bertujuan untuk mengungkapkan peran penting pendidikan karakter dalam mewujudkan sumber daya manusia berdaya saing menuju Indonesia Emas 2045. Karakter yang dibangun meliputi sikap religius, nasionalis, integritas, mandiri dan gotong royong. Metode riset yang dipergunakan dalam penelitian ini adalah kajian literatur (literature review). Hasil riset menggambarkan bahwa pendidikan karakter dapat dijadikan sebagai salah satu upaya dalam meningkatkan mutu sumber daya manusia di Indonesia. Pendidikan karakter merupakan upaya yang dilakukan dengan sengaja untuk membantu seseorang dalam memahami serta bertindak sesuai dengan nilai etika. Sumber daya manusia di masa depan harus dapat diterima dan sanggup bersaing bersama tenaga kerja global. Dengan pendidikan karakter, generasi emas 2045 dapat dipersiapkan dan diyakini memiliki daya saing.
Analysis of the role of motivating operations in the therapeutic verbal interaction
Authors: Estal-Muñoz Víctor , Andrés-López Natalia , Pereira Gladis L. , Gálvez-Delgado Elena , Froxán-Parga María Xesús
Published: June 2023

The concept of motivating operation (MO) helps to overcome both theoretical and practical problems of the traditional notion of motivation in the study of the therapeutic process. In this research, the role of three types of therapists’ verbalizations with an MO function was analyzed, in addition to their association with clients’ verbal behavior. For this purpose, recordings of 40 clinical sessions belonging to 9 different cases were observed. The ACOVEO System was the observational category system used to identify the therapists’ verbal MOs coded as MO with clinical information, MO with consequences, and MO with pairings. The SISC-CVC was the one used to identify clients’ verbalizations coded as Agreement and Disagreement. Sequential analyses were performed to test the relation between the three different types of MOs with themselves, as well as with clients’ concurrence. Results showed that the different MOs were emitted in chunks and when MO with clinical information was uttered either with MO with consequences or MO with pairings there was a greater association with Agreement (r = 2.47; r = 1.86) rather than with Disagreement (r = -.53; r = -.36). These findings highlight the importance of the emission of MOs that associate directly events with an eliciting component with clients’ behavior, giving more efficacious strategies to the therapists

El concepto de operación motivadora (OM) ayuda a suplir los problemas de la noción tradicional de motivación en el estudio del proceso terapéutico. En este trabajo, se analizó el rol de tres tipos de verbalizaciones del terapeuta con una función de OM y se comprobó su relación con el comportamiento verbal de los clientes. Para tal propósito, se observaron grabaciones de 40 sesiones de terapia pertenecientes a 9 casos diferentes. El Sistema ACOVEO fue el sistema de categorías empleado para identificar las categorías OM con información clínica, OM con consecuencias y OM con emparejamiento. El SISC-CVC fue aquel utilizado para identificar las verbalizaciones de las clientes codificadas como Acuerdo y Desacuerdo. Se llevaron a cabo análisis secuenciales para comprobar la relación entre las diferentes OMs entre ellas y con el acuerdo del cliente. Los resultados mostraron que las diferentes OMs fueron emitidas en bloque y que cuando la categoría OM con información clínica se emitía con OM con consecuencias o con OM con emparejamiento se encontraba una mayor asociación con la categoría de Acuerdo (r = 2.47; r = 1.86) que con la de Desacuerdo (r = -.53; r = -.36). Estos resultados destacan la importancia de la emisión de OMs que asocian de manera directa el comportamiento del cliente con eventos con un componente elicitador, ofreciendo estrategias más eficaces para los terapeutas.
Towards Classifying the Polynomial-Time Solvability of Temporal Betweenness Centrality
Authors: Rymar Maciej , Molter Hendrik , Nichterlein André , Niedermeier Rolf
Published: June 2023

In static graphs, the betweenness centrality of a graph vertex measures
how many times this vertex is part of a shortest path between
any two graph vertices. Betweenness centrality is efficiently computable and
it is a fundamental tool in network science. Continuing and extending previous
work, we study the efficient computability of betweenness centrality in
temporal graphs (graphs with fixed vertex set but time-varying
edge sets). Unlike in the static case, there
are numerous natural notions of being a ''shortest'' temporal path (walk).
Depending on which notion is used, it was already observed
that the problem is #P-hard in some cases while polynomial-time solvable
in others. In this conceptual work, we contribute towards classifying
what a ''shortest path (walk) concept'' has to fulfill in
order to gain polynomial-time computability of temporal betweenness centrality.
Pirie, Fernanda. Ordenar el mundo. Cómo 4.000 años de leyes dieron forma a la civilización. Traducción de Yolanda Fontal. Barcelona: Editorial Planeta, 2022.
Authors: Marcone Lo Presti Rodolfo André
Published: June 2023

Recensión de: Pirie, Fernanda. Ordenar el mundo. Cómo 4.000 años de leyes dieron forma a la civilización. Traducción de Yolanda Fontal. Barcelona: Editorial Planeta, 2022.
Catecholaminergic neuromodulation and selective attention jointly shape perceptual decision making
Authors: Nuiten S.A. , De Gee J.W. , Fahrenfort J.J. , van Gaal S.
Published: June 2023

Perception of sensory input is influenced by fluctuations in ongoing neural activity, most prominently driven by attention and neuromodulator systems. It is currently unknown if neuromodulator activity and attention differentially modulate neural activity and perception or whether neuromodulatory systems in fact control attentional processes. We pharmacologically enhanced cholinergic (through donepezil) and catecholaminergic (through atomoxetine) levels in humans performing a visual attention task to investigate the effects of neuromodulatory drive and spatial attention on neural activity and behavior. Attention and catecholaminergic enhancement both improved perceptual sensitivity by increasing the rate of evidence accumulation towards a decision threshold (cholinergic effects were negligible). Electroencephalographic recordings revealed that attention and catecholaminergic enhancement both modulated pre-stimulus cortical excitability, evoked sensory processes and parietal evidence accumulation. Crucially however, the spatial profile and timing of these effects were remarkably different. This suggests that selective attention and neuromodulatory systems shape perception largely independently and in qualitatively different ways.
Extensive re-modelling of the cell wall during the development of Staphylococcus aureus bacteraemia
Authors: Douglas Edward J.A. , Palk Nathanael , Brignoli Tarcisio , Altwiley Dina , Boura Marcia , Laabei Maisem , Recker Mario , Cheung Gordon Y.C. , Liu Ryan , Hsieh Roger C. , Otto Michael , O’Brien Eoin , McLoughlin Rachel M. , Massey Ruth C.
Published: June 2023

The bloodstream represents a hostile environment that bacteria must overcome to cause bacteraemia. To understand how the major human pathogen
Staphylococcus aureus
manages this we have utilised a functional genomics approach to identify a number of new loci that affect the ability of the bacteria to survive exposure to serum, the critical first step in the development of bacteraemia. The expression of one of these genes,
tcaA,
was found to be induced upon exposure to serum, and we show that it is involved in the elaboration of a critical virulence factor, the wall teichoic acids (WTA), within the cell envelope. The activity of the TcaA protein alters the sensitivity of the bacteria to cell wall attacking agents, including antimicrobial peptides, human defence fatty acids, and several antibiotics. This protein also affects the autolytic activity and lysostaphin sensitivity of the bacteria, suggesting that in addition to changing WTA abundance in the cell envelope, it also plays a role in peptidoglycan crosslinking. With TcaA rendering the bacteria more susceptible to serum killing, while simultaneously increasing the abundance of WTA in the cell envelope, it was unclear what effect this protein may have during infection. To explore this, we examined human data and performed murine experimental infections. Collectively, our data suggests that whilst mutations in
tcaA
are selected for during bacteraemia, this protein positively contributes to the virulence of
S. aureus
through its involvement in altering the cell wall architecture of the bacteria, a process that appears to play a key role in the development of bacteraemia.
Mechanistic and evolutionary insights into isoform-specific ‘supercharging’ in DCLK family kinases
Authors: Venkat Aarya , Watterson Grace , Byrne Dominic P. , O’Boyle Brady , Shrestha Safal , Gravel Nathan , Fairweather Emma E. , Daly Leonard A. , Bunn Claire , Yeung Wayland , Aggarwal Ishan , Katiyar Samiksha , Eyers Claire E. , Eyers Patrick A. , Kannan Natarajan
Published: June 2023

Catalytic signaling outputs of protein kinases are dynamically regulated by an array of structural mechanisms, including allosteric interactions mediated by intrinsically disordered segments flanking the conserved catalytic domain. The Doublecortin Like Kinases (DCLKs) are a family of microtubule-associated proteins characterized by a flexible C-terminal autoregulatory ‘tail’ segment that varies in length across the various human DCLK isoforms. However, the mechanism whereby these isoform-specific variations contribute to unique modes of autoregulation is not well understood. Here, we employ a combination of statistical sequence analysis, molecular dynamics simulations and
in vitro
mutational analysis to define hallmarks of DCLK family evolutionary divergence, including analysis of splice variants within the DCLK1 sub-family, which arise through alternative codon usage and serve to ‘supercharge’ the inhibitory potential of the DCLK1 C-tail. We identify co-conserved motifs that readily distinguish DCLKs from all other Calcium Calmodulin Kinases (CAMKs), and a ‘Swiss-army’ assembly of distinct motifs that tether the C-terminal tail to conserved ATP and substrate-binding regions of the catalytic domain to generate a scaffold for auto-regulation through C-tail dynamics. Consistently, deletions and mutations that alter C-terminal tail length or interfere with co-conserved interactions within the catalytic domain alter intrinsic protein stability, nucleotide/inhibitor-binding, and catalytic activity, suggesting isoform-specific regulation of activity through alternative splicing. Our studies provide a detailed framework for investigating kinome–wide regulation of catalytic output through cis-regulatory events mediated by intrinsically disordered segments, opening new avenues for the design of mechanistically-divergent DCLK1 modulators, stabilizers or degraders.
Adenylnucleotide-mediated binding of the PII-like protein SbtB contributes to controlling activity of the cyanobacterial bicarbonate transporter SbtA
Authors: Förster Britta , Mukherjee Bratati , Rourke Loraine M. , Kaczmarski Joe A. , Jackson Colin J. , Price G. Dean
Published: June 2023

Cyanobacteria have evolved a remarkably powerful CO
2
concentrating mechanism (CCM), enabling high photosynthetic rates in environments with limited inorganic carbon (Ci). Therefore, this CCM is a promising system for integration into higher plant chloroplasts to boost photosynthetic efficiency and yield. The CCM depends on active Ci uptake, facilitated by bicarbonate transporters and CO
2
pumps, to elevate CO
2
concentration around the active sites of the primary CO
2
fixing enzyme, Rubisco, which is encapsulated in cytoplasmic micro-compartments (carboxysomes). The essential CCM proteins have been identified, but the molecular signals and regulators that coordinate function in response to light, Ci availability and other environmental cues are largely unknown. Here, we provide evidence, based on a novel
in vitro
binding system, for a role of the PII-like SbtB protein in regulating Ci uptake by the bicarbonate transporter, SbtA, in response to the cellular adenylate energy charge (AEC) through dynamic protein-protein interaction. Binding of the SbtA and SbtB proteins from two phylogenetically distant species,
Cyanobium sp
. PCC7001 and
Synechococcus elongatus
PCC7942, was inhibited by high ATP, and promoted by low [ATP]:[ADP or AMP] ratios
in vitro
, consistent with a sensory response to the AEC mediated through adenylnucleotide ligand-specific conformation changes in SbtB.
In vivo
, cell cultures of S. elongatus showed up to 70% SbtB-dependent down-regulation of SbtA bicarbonate uptake activity specifically in the light activation phase during transitions from dark to low light when low cellular AEC is expected to limit metabolic activity. This suggests SbtB may function as a curfew protein during prolonged low cellular AEC and photosynthetically unfavourable conditions to prevent energetically futile and physiologically disadvantageous activation of SbtA.
En utdanningsreforms møte med ulike skolekulturer og forståelsesrammer
Authors: Karstensen Steinar , Aakernes Nina
Published: June 2023

Hensikten med denne artikkelen er å bidra med kunnskap om hvordan ulike skolekulturer og yrkesfaglæreres ulike utdannings- og yrkesbakgrunn har preget deres tolkning av læreplanen i et nytt utdanningsprogram. Utdanningsreformer som er vedtatt på nasjonalt nivå fortolkes og gjennomføres i møte med den enkelte skoles eller lærerteams kultur og forståelsesramme. Det kan derfor utvikle seg ulike praksiser på skoler innenfor det samme utdanningsprogrammet. Artikkelen bygger på data fra gruppeintervjuer med lærerteam på vg1 informasjonsteknologi og medieproduksjon (IM) på fire utvalgte skoler. Utdanningsprogrammet er en nyetablering, men består også av elementer fra utdanningstilbudene IKT-servicefag og medieproduksjon/medier og kommunikasjon, som har sine tradisjoner, særegenheter og fellestrekk. Den teknologiske utviklingen vil kreve store omlegginger i yrkesopplæringen de kommende årene, og studien bidrar med kunnskap om hvilke forhold som preger enkeltlæreres og lærerteams møte med pågående omstillingsprosesser i yrkesopplæringen. Ved bruk av annen generasjons aktivitetsteori analyserer vi hvilke forhold som har hatt betydning for fire IM-avdelingers møte med den nye læreplanen. Resultatene viser at lærernes utdanning, yrkesbakgrunn og tradisjoner i de tidligere utdanningsprogrammene har preget tolkningen av læreplanen. Imidlertid indikerer studien at samarbeidskulturen på den enkelte avdeling har vært mest avgjørende for hvordan lærerne har opplevd den første fasen av implementeringsarbeidet.
BinBench: a benchmark for x64 portable operating system interface binary function representations
Authors: Console Francesca , D’Aquanno Giuseppe , Di Luna Giuseppe Antonio , Querzoni Leonardo
Published: June 2023

In this article we propose the first multi-task benchmark for evaluating the performances of machine learning models that work on low level assembly functions. While the use of multi-task benchmark is a standard in the natural language processing (NLP) field, such practice is unknown in the field of assembly language processing. However, in the latest years there has been a strong push in the use of deep neural networks architectures borrowed from NLP to solve problems on assembly code. A first advantage of having a standard benchmark is the one of making different works comparable without effort of reproducing third part solutions. The second advantage is the one of being able to test the generality of a machine learning model on several tasks. For these reasons, we propose BinBench, a benchmark for binary function models. The benchmark includes various binary analysis tasks, as well as a dataset of binary functions on which tasks should be solved. The dataset is publicly available and it has been evaluated using baseline models.
Phylogeography of sharks and rays: a global review based on life history traits and biogeographic partitions
Authors: Kottillil Sudha , Rao Chetan , Bowen Brian W. , Shanker Kartik
Published: June 2023

Considerable research exists on the life history traits, evolutionary history, and environmental factors that shape the population genetic structure of marine organisms, including sharks and rays. Conservation concerns are particularly strong for this group as they are highly susceptible to anthropogenic stressors due to a combination of life history traits including late maturity and low fecundity. Here, we provide a review and synthesis of the global phylogeography of sharks and rays. We examined existing data for 40 species of sharks belonging to 17 genera and 19 species of rays belonging to 11 genera. Median joining haplotype networks were constructed for each species for the mtDNA cytochrome C oxidase subunit I (COI), and an Analysis of Molecular Variance (AMOVA) was conducted to understand patterns of genetic diversity and structure across the three major ocean basins—the Indian, Atlantic and Pacific Oceans. Haplotype networks showed very shallow coalescence in most species, a finding previously reported for marine teleosts. Star topologies were predominant among sharks while complex mutational topologies predominated among rays, a finding we attribute to extremely limited dispersal in the early life history of rays. Population structuring varied amongst species groups, apparently due to differences in life history traits including reproductive philopatry, site fidelity, pelagic habitat, migratory habits, and dispersal ability. In comparison to reef-associated and demersal species, pelagic and semi pelagic species showed lower levels of structure between and within ocean basins. As expected, there is variation between taxa and groups, but there are also some broad patterns that can guide management and conservation strategies.
Baseline dynamics of Symbiodiniaceae genera and photochemical efficiency in corals from reefs with different thermal histories
Authors: McRae Crystal J. , Keshavmurthy Shashank , Chen Hung-Kai , Ye Zong-Min , Meng Pei-Jie , Rosset Sabrina L. , Huang Wen-Bin , Chen Chaolun Allen , Fan Tung-Yung , Côté Isabelle M.
Published: June 2023

Ocean warming and marine heatwaves induced by climate change are impacting coral reefs globally, leading to coral bleaching and mortality. Yet, coral resistance and resilience to warming are not uniform across reef sites and corals can show inter- and intraspecific variability. To understand changes in coral health and to elucidate mechanisms of coral thermal tolerance, baseline data on the dynamics of coral holobiont performance under non-stressed conditions are needed. We monitored the seasonal dynamics of algal symbionts (family Symbiodiniaceae) hosted by corals from a chronically warmed and thermally variable reef compared to a thermally stable reef in southern Taiwan over 15 months. We assessed the genera and photochemical efficiency of Symbiodiniaceae in three coral species: Acropora nana, Pocillopora acuta, and Porites lutea. Both Durusdinium and Cladocopium were present in all coral species at both reef sites across all seasons, but general trends in their detection (based on qPCR cycle) varied between sites and among species. Photochemical efficiency (i.e., maximum quantum yield; Fv/Fm) was relatively similar between reef sites but differed consistently among species; no clear evidence of seasonal trends in Fv/Fm was found. Quantifying natural Symbiodiniaceae dynamics can help facilitate a more comprehensive interpretation of thermal tolerance response as well as plasticity potential of the coral holobiont.
Temas prioritários sobre transparência ativa em instituições federais de ensino superior: um mapeamento sistemático
Authors: De Souza Diego Fillipe , Cavalcanti Emilly Kessia da Costa , Castro Marcos Paulo de Assis , Azevedo Érika Sabrina Felix , Neto Jorge da Silva Correia
Published: June 2023

Iniciativas voltadas para participação cidadã, transparência e uso das tecnologias têm conduzido a gestão pública para novos direcionamentos. O governo aberto é uma iniciativa internacional que fomenta a atuação de governos mais transparentes, responsáveis e abertos à participação social. Uma iniciativa interessante aplicada no Brasil é a disseminação de informações de interesse coletivo de maneira proativa para a sociedade por estes órgãos e entidades, inclusive de instituições federais de ensino superior (IFES), por seu papel social e potencial de difusão de conhecimento para a sociedade. Nesse contexto, o objetivo deste trabalho consiste em identificar quais os temas de interesse coletivo em IFES para o devido cumprimento da transparência ativa. Para isso foram realizados um levantamento bibliográfico, uma pesquisa documental e um estudo de mapeamento sistemático, potencializando os resultados encontrados. Como resultados foram identificados alguns temas gerais e específicos de interesse coletivo em IFES.
Impactos ambientais na fauna silvestre causado pelo crescimento urbano da cidade de Manaus-AM
Authors: Pinheiro Elisângela Almeida , Roberto José Carlos Alves , Souto Sistina Pereira , Lima Suelen Costa
Published: June 2023

Este artigo tem por objetivo trazer um resumo bibliográfico acerca da temática de impactos ambientais na fauna silvestre que são causados pelo crescimento urbano nas cidades sendo a área de estudo a cidade de Manaus no estado do Amazonas, com base em pesquisa bibliográfica em sites de buscas acadêmica como o google acadêmico, periódicos capes, bases de teses e dissertações dos trabalhos já realizado sobre a temática e estudos já realizados na cidade de Manaus-AM, sendo os impactos ambientais o causado de inúmeros impactos na fauna silvestre uma das mais importantes discutida é a retirada da vegetação e o maior impacto que isso causa a fauna silvestre que tem a perca do seu habitat e acaba ficando refugiada em fragmentos florestais no meio urbano e tentando sobreviver em meio a agitação da cidade urbana, caracteriza impacto ambiental são as alterações que provoquem o desequilíbrio das relações constitutivas do ambiente e para mitigar esses impactos tem que se pensar em técnicas e meio com participação da população e salvar a fauna silvestre em meio ao meio urbano.
Effects of Serum Albumin Level in Section Lower vs Upper Extremity Surgery: A Hospital-based Retrospective Study
Authors: Bandyopadhyay Tushar Kanti , Pathak Amita
Published: June 2023

Introduction: Trauma and major surgery often lead to low serum albumin level in patients. Several studies have been reported showing depressed serum albumin level in upper, lower extremity and other major surgery. Metabolic stress response from major surgical interventions and prolonged immobility are primarily responsible for low serum albumin level in these patients. Aim: To investigate the preoperative and postoperative serum albumin levels in patients who underwent extremity surgery and compare the changes in albumin levels between those who underwent upper extremities surgery versus lower extremities surgery. Materials and Methods: This was a hospital-based retrospective study, including 120 patients, who presented to the Emergency Department of Surgery and Orthopaedics, in Deben Mahata Government Medical College and Hospital, Purulia, West Bengal, India, due to trauma included in the present study (on and from November 30 2018 to November 30 2021). All the patients underwent either lower or upper extremity surgery (Group 1 and Group 2, respectively) by orthopaedic surgeons and were consecutively selected regardless of their ages. The serum albumin levels at the time of admission and on the third day after surgery were obtained from the hospital patient records. Continuous variables were expressed as mean±standard deviation. The normality test of the numerical variables using Kolmogorov-Smirnov test. Results: Mean age of population in the upper extremities surgery group was 38.8 years vs 30.5 years in the lower extremities. A statistically significant difference in the preoperative and postoperative serum albumin levels was found in both groups (p<0.05). Moreover, the mean difference between preoperative and postoperative serum albumin levels was found to be significantly higher in the lower extremity group (1.52±0.32 gm/dL) than in the upper extremity group (0.95±0.39 g/dL) (p<0.05) and the coefficient of correlation between these two groups r> 0.7 indicating significant difference between albumin levels in two groups. Conclusion: This study revealed that both upper and lower extremity surgeries caused hypoalbuminemia. The study was novel in finding that lower extremity surgery caused more severe hypoalbuminemia in the patients compared with the patients of upper extremity surgery. A correlation study done between two groups and was found to be significant with p-value <0.05 and r value> 0.7. The reason for this significant difference was the longer duration of lower extremity surgery requiring more fluid support during the surgery and resultant increased metabolic stress.