bluuebunny/crossref_metadata_2025 huggingface dataset:
Penerapan Nilai-Nilai Pancasila dalam Etika Manajemen Sumber Daya Manusia: Sebuah Tinjauan Sistematis dalam Konteks Indonesia
Authors: Irawan Iwan
Published: November 2024

Penerapan nilai-nilai Pancasila dalam manajemen sumber daya manusia (SDM) di Indonesia menghadapi tantangan signifikan, terutama di tengah arus globalisasi dan digitalisasi yang pesat. Meskipun Pancasila telah lama diakui sebagai landasan etika bangsa, integrasinya dalam praktik manajemen SDM modern masih terbatas dan sulit diterapkan dalam konteks kerja yang semakin kompetitif. Nilai-nilai seperti keadilan sosial, kemanusiaan, persatuan, dan demokrasi kerap terabaikan karena fokus organisasi lebih diarahkan pada produktivitas dan hasil. Persoalan semakin kompleks dengan berkembangnya teknologi digital dalam manajemen SDM, yang memunculkan tantangan baru terkait etika, khususnya dalam hal privasi data dan perlindungan hak-hak karyawan. Organisasi menghadapi dilema antara memanfaatkan teknologi untuk efisiensi kerja dan menjaga prinsip-prinsip etika yang selaras dengan nilai Pancasila. Untuk menjawab tantangan ini, diperlukan pendekatan sistematis yang mampu mengoperasionalisasikan nilai-nilai Pancasila dalam praktik SDM. Pendekatan ini bertujuan menjembatani kesenjangan antara idealisme nasional yang diusung oleh Pancasila dan praktik organisasi yang ada, agar tercipta keseimbangan antara etika nasional dan tuntutan globalisasi. Dengan menggunakan pendekatan kualitatif, penelitian ini meninjau berbagai literatur dan menganalisis tantangan yang ada guna merumuskan strategi praktis penerapan Pancasila dalam manajemen SDM. Temuan menunjukkan bahwa meskipun nilai-nilai Pancasila diakui, kekurangan pedoman konkret menjadi hambatan utama dalam implementasinya. Hasil penelitian ini menekankan pentingnya pendidikan karakter berbasis Pancasila dan pengembangan kebijakan digital yang etis sebagai dasar untuk memperkuat loyalitas karyawan dan melindungi hak-hak mereka. Dengan implementasi yang lebih sistematis, organisasi di Indonesia diharapkan dapat memperkuat identitas nasional sambil beradaptasi dengan tuntutan global, sehingga memberikan kontribusi signifikan pada pengembangan SDM yang berkelanjutan, etis, dan berwawasan kebangsaan.
Colouring Resistance: A Reflection on Art and Activism (Summer 2017)
Authors: Ahmed Binish
Published: November 2024

In "Colouring Resistance," Binish Ahmed poetically explores the intersection of race and resistance. Ahmed uses the language of "colours" as a politically symbolic reference to diverse identities. Her work engages with Indigeneity within a global context, with place-specific implications. Ahmed calls for an intersectional approach to activism that takes the complexities and nuances she highlights into account, such as place-based responsibilities to land. Drawing on critical race, Indigenous feminism, and anti-colonial theory, in this work she examines the politics of visibility, invisibility, and the complexities of solidarity among racialized and marginalized communities. 
Advancing the spatiotemporal dimension of wildlife–pollution interactions
Authors: Brand Jack , Martin Jake , Michelangeli Marcus , Thoré Eli , Sandoval-Herrera Natalia , McCallum Erin , Szabo Drew , Callahan Damien , Clark Timothy , Bertram Michael , Brodin Tomas
Published: November 2024

Chemical pollution is a pervasive problem and is now considered the fastest-growing agent of global environmental change. Numerous pollutants are known to disrupt animal behaviour, alter ecological interactions, and shift evolutionary trajectories. Crucially, both chemical pollutants and individual organisms are non-randomly distributed throughout the environment. Despite this, the current evidence for chemical-induced impacts largely stems from tests that restrict organism movement and force homogenous exposures. While such approaches have provided pivotal ecotoxicological insights, they ignore the spatiotemporal dimension of wildlife–pollution interactions, which are key to accurately predicting the impacts of chemical pollutants on free-roaming wildlife. Indeed, the seemingly simple notion that pollutants and animals move non-randomly in the environment creates a complex of dynamic interactions, many of which have never been theoretically modelled or experimentally tested. Here, we conceptualise potential dynamic interactions between spatiotemporal variation in pollutants and individual organisms, and highlight how these processes could scale up to have substantial ecological and evolutionary impacts across populations, communities, and whole ecosystems. We conclude by outlining technological advancements and approaches that will facilitate the necessary spatiotemporal integration in ecotoxicology, and a three-pronged approach—in silico modelling, laboratory approaches, and field approaches—to guide future research.
Harmony of Bank Structure Ownership through Tri Hita Karana Cultural Concept
Authors: Sukendri Nengah , Muktiyanto Ali , Geraldina Ira , Safitri Julia
Published: November 2024

Tri Hita Karana is a philosophy of balance originating from Bali. From a banking perspective, Parahyangan can be interpreted as ethical and responsible governance. Pawongan reflects the balance of interests between various interested parties, from shareholders to management, employees, and customers. Palemahan is the bank's commitment to supporting sustainable and environmentally friendly economic development. This study aims to explore the harmonization of bank ownership through the cultural principles of Tri Hita Karana. The method in this article is a descriptive qualitative approach with a literature review that explores local wisdom theory specifically. Implementing Tri Hita Karana principles can create a more harmonious, transparent, and sustainable bank ownership structure. This can be achieved through strong governance policies, balanced ownership distribution, and commitment to social and environmental responsibility. Harmonizing the bank ownership structure through Tri Hita Karana can improve bank performance, strengthen public trust, and comprehensively contribute to the financial system's stability. Through the Tri Hita Karana Concept, the Bank Ownership Structure is a financial matter and a vehicle to realize harmonization between religious values and spirituality, common welfare, and environmental sustainability. The harmony model of the Tri Hita Karana-based bank ownership structure illustrates that by integrating Tri Hita Karana, Corporate Social Responsibility, and Triple Bottom Line, organizations can balance spiritual, social, environmental, and economic aspects and ensure long-term sustainability.
Tingkat Partisipasi Anggota KWT Mawar dalam Program Harum Madu di Desa Karangtengah, Kecamatan Kadungora, Kabupaten Garut
Authors: Af'idah Rivianty Putri Nur , Abubakar Abubakar , Budiandrian Bayu
Published: November 2024

Program Halaman Rumah Masyarakat Terpadu (Harum Madu) merupakan inisiatif Pemerintah Kabupaten Garut untuk menjamin ketersediaan pangan mandiri di tingkat rumah tangga. Berdasarkan data BPS (2023), lahan pertanian di Kecamatan Kadungora sangat terbatas, sehingga program Harum Madu dapat menjadi solusi untuk mengoptimalkan lahan pekarangan. Penelitian ini bertujuan untuk menganalisis karakteristik responden dan tingkat partisipasi anggota KWT Mawar dalam program Harum Madu. Metode yang digunakan adalah analisis deskriptif kuantitatif, dengan pengambilan sampel secara sensus terhadap seluruh 40 anggota KWT Mawar. Hasil penelitian menunjukkan bahwa mayoritas anggota KWT Mawar berusia 34-44 tahun, berpendidikan terakhir tingkat SD, bekerja sebagai ibu rumah tangga, memiliki 1-3 tanggungan keluarga, dan tingkat pendapatan rumah tangga rata-rata sebesar Rp.1.500.000-Rp.2.000.000. Tingkat partisipasi anggota KWT Mawar dalam program Harum Madu tergolong sedang dengan skor 1485. Partisipasi dalam pengambilan keputusan termasuk kategori sedang, sementara partisipasi dalam pelaksanaan dan pemanfaatan hasil tergolong tinggi. Adapun partisipasi dalam evaluasi berada pada kategori sedang.
Development of Green Extraction Using Natural Deep Eutectic Solvent (NADES) for Separation Polyphenolic Compounds from Spilanthes acmella
Authors: Nurhidayati Isna , Maimulyanti Askal , Mellisani Bella , Puspita Fitria , Rachmawati Putri Fajar Amelia , Widarsih Wiwi , Prihadi Anton Restu
Published: November 2024

Natural deep eutectic solvent (NADES) is an alternative to conventional solvents in polyphenol extraction. Its composition of choline chloride combined with fructose, choline chloride with lactic acid, choline chloride with glycerol, choline chloride with propylene glycol, and choline chloride with proline have been sucessfully set using the thermal mixing method. Choline chloride served as the hydrogen bond acceptor (HBA), while the others acted as hydrogen bond donors (HBDs) at a mole ratio of 1:2. This study aimed to extract polyphenols from the flowers, stalks, stems, and leaves of Spilanthes acmella, using NADESs. The extraction process was conducted by adding 20% water to the mixture with a ratio of the sample to solvent of 1:10 (w/v), for 60 min. The extract concentration was assessed through spectroscopic photometry using the Folin-Ciocalteu method. The result showed that the choline chloride-glycerol NADES was the most appropriate solvent for the extraction of polyphenols from the flowers of the plant. Meanwhile, the best NADES for the extraction from the stems, stalks, and leaves, was the mixture of choline chloride and fructose. The highest polyphenol concentration was obtained in the stems at 2545.192 mg/L. The yield obtained in the stems, leaves, stalks, and flower were 25.452, 6.284, 3.111 and 2.415 mg gallic acid equivalent/g (GAE/g), respectively. These findings suggest that NADES can be used as an eco-friendly alternative solvent for green extraction processes of active compounds from natural materials, especially polyphenols from S. acmella.
The Effect of the Layup on the Stability of Composite Cylindrical Shells
Authors: Máté Péter , Szekrényes András
Published: November 2024

Fiber reinforced plastic laminated composites have conquered greater and greater territory in the field of engineering in the past decades for their high strength to weight ratio. By varying the layup structure their behavior can easily be modified. One of the applications, that is investigated in this article is the slit tube or cylindrical shell, that used as a structural element undergoes bending. These shells indifferent from their material may experience the snap-through phenomenon (this depends both on the material and geometry) in which the shell flattens and loses its stability to bending. Depending on the layup bistable behavior also can be achieved, i.e., the shell would have two different shapes that are in equilibrium without any constraint. In this article the effect of the layup is investigated both on the bistable behavior and the snap-through phenomenon. Geometric limitations for the bistability are calculated based on a simple beam model from the literature. The same model is used to find the snap-through moment for these shells as a function of the orientation angle. It is also proven that the flattening of the shell cannot be evaded by changing the layup structure. The results are confirmed by FE simulations where applicable.
The Weight of History Brazil's Economic Paradox from Estado Novo to Neoliberalism (1930-2000)
Authors:   Universidade de Aveiro Portugal, Montgomery Richard Murdoch
Published: November 2024

This study examines Brazil's complex economic journey from 1930 to 2000, exploring the interplay between historical legacies, policy choices, and global economic forces in shaping the nation's development trajectory. It argues that Brazil's economic history during this period is characterized by a series of paradoxes: rapid industrialization alongside persistent inequality, economic miracles followed by devastating crises, and modernization efforts constrained by colonial-era structures. The analysis begins with the Estado Novo of Getúlio Vargas, tracing the evolution of Brazil's economy through state-led industrialization, the "Economic Miracle" of the military regime, the debt crisis and hyperinflation of the 1980s, and the neoliberal reforms of the 1990s. Special attention is given to the enduring impact of slavery and colonial land distribution on Brazil's social and economic structures. The study highlights how these historical factors have contributed to ongoing challenges such as regional disparities, income inequality, and the "Brazil Cost." By examining these issues, the paper provides insights into the complexities of economic development in postcolonial societies and the challenges of overcoming historical constraints in the pursuit of equitable and sustainable growth.
Desain Meteran Air Prabayar Berbasis Sensor YF-S201 dengan Generator Air Mini Sebagai Catu Daya
Authors: Fitriyanto Indra , Amri Fauzan , Robiyanto Robi
Published: November 2024

Banyak PDAM saat ini masih melakukan pencatatan penggunaan air oleh pelanggan secara manual, sehingga rawan terjadi kesalahan pencatatan. Oleh karena itu perlu dikembangkan sebuah meteran air yang mampu meminimalisir kesalahan pencatatan oleh petugas, salah satunya adalah dengan menerapkan meteran air prabayar. Namun, dalam beberapa penelitian meteran air belum ada yang membahas sumber energi yang digunakan untuk menyalakan meteran air tersebut. Dalam penelitian ini dikembangkan sebuah meteran air prabayar dengan menggunakan sensor aliran air YF-S201 yang dikopel dengan generator air mini sebagai catu daya. Energi yang dihasilkan oleh generator kemudian disimpan ke dalam baterai. Prinsip kerja dari meteran ini adalah valve akan terbuka ketika pelanggan mengisikan token pada meteran, dan valve akan menutup ketika token tersebut sudah habis.  Meteran air yang dibuat kemudian dibandingkan dengan meteran air konvensional yang sudah standar. Berdasarkan hasil pengujian diperoleh selisih pembacaan volume rata-rata adalah 99,3 mL dan error rata-rata 3,61%. Sedangkan pengujian generator diperoleh tegangan maksimum yang dihasilkan adalah 12V ketika debit air 3,71 L/m. Sehingga dapat disimpulkan bahwa meteran air prabayar yang dikembangkan layak untuk digunakan.
Tingkat Kesehatan Bank: Pendekatan Risk Based Bank Rating terhadap Nilai Perusahaan
Authors: Murwani Juli , Taufiq Abd Rohman
Published: November 2024

Conventional National Private Banks as one of the companies that contribute to stabilizing the national economy need to maintain their health level by implementing various applicable policies. To maintain the soundness of the bank, it must be able to stabilize its performance so that it has an impact on the trust of stakeholders in the bank. Thus the purpose of banking will be fulfilled, namely to maximize the value of the company. This research was conducted at Conventional National Private Commercial Banks listed on the IDX 2016-2020. The data source is secondary data obtained from the annual report of each bank which is the sample of the study as many as 32 banks. The research method used is a quantitative approach using multiple linear regression analysis and using SPSS version 18 program assistance. The results of this research are GCG variable with independent commissioner board size proxy, profitability with BOPO ratio has no effect on firm value. While the risk profile using the LDR ratio, capital as measured by the CAR ratio has an effect on firm value. The variable size of the bank is not able to moderate the effect of GCG on firm value.
Application of the C4.5 Algorithm for Predicting Students' Learning Styles Based on Somatic, Auditory, Visual, and Intellectual Models
Authors: Aminah Siti , Yadi Yadi
Published: November 2024

Education in Indonesia has seen significant development over the past few decades, with government efforts to improve access and quality of education throughout the country. Programs such as the 12-Year Compulsory Education and curriculum revitalization have driven an increase in school participation rates. However, challenges such as the quality gap between urban and rural areas and the low competence of teachers remain key issues in achieving more equitable and high-quality education for all segments of society. This study aims to apply the C4.5 algorithm to predict students' learning styles based on the Somatic, Auditory, Visual, and Intellectual (SAVI) model. Learning styles are an important aspect of education that affects the effectiveness of learning. By understanding individual learning styles, educators can optimize teaching methods according to students' needs. In this study, student learning style data was collected and analyzed using the C4.5 algorithm, an effective decision tree method for data classification. The results of this algorithm are decision trees that categorize students into one of four learning styles based on specific features. This study shows that the C4.5 algorithm has good accuracy in predicting learning styles, with an entropy value of 1.55 and a gain of 0.156. The implementation of the results of this study is expected to help teachers develop more optimal teaching strategies in preparing learning materials according to students' learning styles.
The Oyster Mushroom Harvesting Determination System Based On Image Processing and Multi Layer Perceptron
Authors: Husain Nursuci Putri , Kadir Muh. Ichwan , P Muh. Dzulkifli
Published: November 2024

Oyster mushroom cultivation in Indonesia has seen rapid growth in recent years, particularly in South Sulawesi. The demand for oyster mushrooms is increasing as they are considered a nutritious food source. However, mushroom farmers are currently unable to fulfill market demand due to limited harvest yields. The primary factor contributing to this issue is the farmers' lack of skills in oyster mushroom cultivation. Therefore, an intelligent system is needed to identify and monitor the growth of oyster mushrooms, which can help to improve harvest yields. In this research, a system for determining oyster mushroom harvest timing will be designed using image processing techniques. This system will work by analyzing images of oyster mushrooms captured using a digital camera on the mushroom growing medium and then identifying visual characteristics that indicate mushroom maturity, such as color, texture, and size. The proposed method consists of several stages: image dataset collection, image preprocessing, image segmentation, morphological operations, feature extraction, and image classification based on Multi-Layer Perceptron (MLP). The dataset obtained includes 150 images of oyster mushrooms, divided into two classes: ready for harvest and not ready for harvest. The test results show that the proposed method can accurately identify oyster mushrooms as either ready for harvest or not. The classification model achieved an accuracy rate of 96.67%. By utilizing this technology, it is expected to enhance efficiency and consistency in the harvesting process and assist farmers in making informed decisions.
Muscle Memory: Exploring the Sociocultural Factors of Sexual Pain in People Assigned Female at Birth
Authors: Beilman Grace
Published: November 2024

According to the American Congress of Obstetrics and Gynecology, “nearly 3 out of 4 women have pain during intercourse at some time during their lives,” which is an under-researched issue, especially when it comes to factors outside of biology (2017). This research paper focuses on examining the most common sociocultural aspects that affect sexual pain in people assigned female at birth (AFAB) between the ages of 18 and 30. A survey was completed by 144 participants, 6 of whom participated in structured interviews. My analysis shows a strong impact of sociocultural factors on experiences of pain during sex in participants. 90.28% of participants had experienced pain during sex at least once in their lives. Seven themes were identified from the data: (1) situations that cause pain, (2) pain during first intercourse, (3) normalization of pain, (4) pain is not “a big deal,” (5) shame, (6) pressure, and (7) expectation of pain during sex.
Employee Well-Being: A Conceptual Framework for Notable Explorations
Authors: Syed Mohd Taha Syarifah Ainul Suhana , Samy Naresh Kumar
Published: November 2024

Employee well-being is recognized as a critical for organizational success especially in Malaysia. Key elements significantly impacting employee well-being include positive leadership styles which are authentic leadership and servant leadership, do affect employee well-being. Thus, this studies highlight the interconnectedness of positive leadership, social capital, and psychological capital, as well as their influence on the well-being of public sector employees in Malaysia. By recognizing these key elements and implementing strategies to enhance employee well-being, public organization can create a working environment that increase employee performance. The proposed research design will be quantitative studies, utilizing validated survey instruments for data collection from a sample size of 450 public sector employees. Thus, data analysis will employ partial least square structural equation modelling (PLS-SEM) to test the research hypotheses. The finding of this study will be developing a conceptual framework that illustrates the interconnectedness of these variables, with research hypotheses are outlines in this paper for committed scholars on employee well-being involving as valuable contributors.
Maternal Object Loss and Feminine Identity: A Single Case Study of a Hysterectomized Nun
Authors: Mireille Ndje Ndje , Chesly Nira Dongmo Tetsopguim , Jacques Philippe Tsala Tsala
Published: November 2024

Hysterectomy is a gynecological surgery that puts an end to the dream of pregnancy and questions the feminine identity as well as the destiny of the fem infinity. The theory of choice stipulates that when a choice is made, the subject anticipates the result of the said choice and integrates it. Moreover, when the loss of the object confirms one's beliefs, the grieving process is facilitated. Put together the above, one would expect that a religious celibate woman, following a consented surgical removal of her uterus, which represents a concrete renunciation of the fantasy and the reality of reproduction, would no longer be subject to suffering related to the said loss. Conversely, we observed the manifestation of psychological suffering linked to the absence of the uterus in a nun. The goal of this study is to understand the place of the uterus in the feminine identity of a religious nun. We used the clinical method, more specifically a single case study. Our data was collected from non structured interviews with a nun who had undergone a hysterectomy. The data collected was subject to content analysis and interpretation based on a dual phenomenological and psychodynamic approach. As a result of this inductive approach, it is clear that the psychological distress is due to the loss of an important object of attachment (Uterus) but the reason for this suffering is linked to the covenant made to God which is revealed as the foundation of her life of faith, of an offering of oneself as a whole. The results of this study therefore provide a clinical conclusion that although some lay and religious women may have difficulty adapting to hysterectomy, the object behind this suffering is different.
Public Health Policies and Programs for Alzheimer’s and Dementia: A Data-Driven Evaluation of Effectiveness and Areas for Improvement in the United States
Authors: Akindahunsi Taiwo , Tundealao Samuel , Adebayo Bamidele Oludele
Published: November 2024

This study evaluates the effectiveness of public health policies and programs addressing Alzheimer's and dementia in the United States, focusing on early detection, disparities in access to care, and service quality variations between urban and rural healthcare facilities. Using data from the World Bank’s QoG, CDC’s Alzheimer’s Disease and Healthy Aging Data Portal, and the Alzheimer's Association, logistic regression models assessed the impact of early detection programs on patient outcomes. Disparities in care access were analyzed using regression models incorporating demographic and geographic data from the National Institute on Aging and the CDC. Service quality was examined through surveys targeting patients and healthcare providers in different settings. The findings highlight that while early detection programs are essential, their availability alone is insufficient without high-quality implementation. Significant disparities in access to care based on age and race were observed, along with pronounced differences in service quality between urban and rural areas. The study recommends enhancing program quality, addressing access disparities, and investing in rural healthcare infrastructure to improve care for Alzheimer's and dementia patients.
STRATEGI KEBERLANJUTAN INOVASI PERKOTAAN: STUDI KASUS PENGEMBANGAN “LORONG WISATA SYDNEY” DI KOTA MAKASSAR
Authors: Majid Ramlan , Salman Ade Reyhan
Published: November 2024

Pemerintah Kota Makassar memprioritaskan intervensi di lokasi Lorong Wisata (Longwis) tertentu berdasarkan potensi dan kondisinya. Hal ini terlihat dari banyaknya lokasi Longwis yang belum tersentuh intervensi, seperti Longwis “Sydney” di Kelurahan Tello Baru, Kecamatan Panakkukang. Longwis ini dipilih karena memiliki keunggulan atau keunikan yang membuatnya layak untuk dikembangkan. Penelitian ini bertujuan untuk mengkaji secara mendalam strategi keberlanjutan Longwis Sydney dalam memberdayakan masyarakat perkotaan setempat. Inovasi Longwis Sydney dinilai berhasil dalam mempertahankan programnya secara berkelanjutan dengan memanfaatkan potensi dan eksistensi ruang ekologisnya yang potensial. Penelitian ini sangat urgen karena menawarkan pemodelan strategi pada suatu komunitas untuk ditiru dan diterapkan di komunitas lain. Penelitian ini menggunakan metode penelitian deskriptif kualitatif dengan pendekatan studi kasus. Hasil penelitian menunjukkan Longwis Sydney menempatkan masyarakat sebagai pelaku utama melalui pemberdayaan masyarakat dalam berbagai kegiatan kepariwisataan dengan memanfaatkan potensi UMKM, tanaman hijau, budidaya ikan, kuliner dan bank sampah yang terbilang aktif. Dalam mempertahankan keberlanjutan lorong wisata, Longwis Sydney melakukan beberapa pendekatan antara lain mengembangkan potensi ekonomi lokal melalui pariwisata berbasis masyarakat, memanfaatkan partisipasi masyarakat yang tinggi dan melakukan evaluasi kelembagaan yang efektif.
Four Monarchies, a Dog, a Cat, and Peg, Meg, or Margaret: “Upward Allusions” in Jonson’s Entertainment at Britain’s Burse
Authors: Blaine Marlin E.
Published: November 2024

This note suggests identifications of the sources of several hitherto unidentified allusions in Jonson’s Entertainment at Britain’s Burse. The clumsiness of each of these allusions by the entertainment’s central character, the Master, contributes to his characterization as rhetorically inept and thus a figure of dubious credibility. Among the sources discussed here are an epigram by Sir John Davies, which Jonson presents in a way that simultaneously mocks his poetic rival and undermines the audience’s confidence in the Master’s critical discernment. The other allusions discussed include an apparent borrowing from a contemporary tract on usury and a garbled reference to a title of a Neo-Latin treatise. In addition, this note explicates the sources of humor involved in the Master’s reference to the Four Monarchies of the book of Daniel. In sum, the allusions discussed here demonstrate a pattern whereby the Master’s attempts to heighten his rhetoric cause him to fall comically into bathos.
Characterization of Murine Monoclonal Antibodies by Hybridomatechnology for the Peste Des Petits Ruminants (PPRV)Vaccine
Authors: Kamal Tahira , Hassan Saeed Ul , Hasan Fariha , Ali Ghulam Muhammad
Published: November 2024

Peste des petites ruminants (PPRV) is an acute and highly contagious viral disease of sheep and goats. It continues to be a major cause of economic losses worldwide. The causative agent is from the genus Morbillivirus. It is very much antigenically similar to the rinderpest virus. In this study, we developed specific monoclonal antibodies (mAbs) against PPRV. These monoclonal antibodies will be used for the future development of diagnostic assays against PPRV. Monoclonal antibodies are widely used in molecular biology and biomedical research. However, the generation of these molecules is complicated and time-consuming. The production of PPRV-specific mAbs involved immunizing BALB/c mice with a commercially available PPRV vaccine. Spleenocytes were then fused with myeloma cells (SP2/0) using polyethylene glycol fusion (PEG fusion). A total of five monoclonal antibodies (mAbs) out of seven were found positive in IELISA These are 1A-1, 2A-5, 3B-5, 4C-2, and 5C-5 raised against the PPRV vaccine. These were developed by the CBIS method (cell-based immunization and screening), that is fusion of myeloma cell line SP2/0 with mice spleenocytes, collected from purified PPRV vaccine immunized mice. These mAbs were then characterized by Indirect ELISA and western blot analysis(SDS-PAGE). One of the positive hybridoma clones (3B-5) secreting mAbs belonged to the IgG class, which was purified using a Protein A- Plus spin kit (Thermo Scientific) and showed a single band in SDS-PAGE. The mAbs named, (3B-5) represented a positive, 70-kDa protein band in SDS-PAGE analysis. The mAbs established in this study are useful for studying the interaction between PPRV and its target cell. The current study effectively characterized the mAbs and found one positive 3B-5 was proved to be efficient for detecting antibodies against PPRV in sheep and goat sera and would use to develop diagnostic assays for PPRV in Pakistan. This is the first ever report from Pakistan, that evaluate the practical approach for the characterization of monoclonal antibodies against the PPRV virus.
El uso del vídeo educativo y el aula invertida en la impartición de prácticas de informática
Authors: González de la Aleja Gallego David , Latorre Balado Marta , Primo Tárraga Eva , Tejedor Sastre María Teresa
Published: November 2024

En este artículo se presenta y evaíua una metodología que combina el uso del vídeo educativo como recurso de aprendizaje con el enfoque de aula invertida en el desarrollo de las prácticas de informática en una asignatura universitaria. La estrategia propuesta permite facilitar la adquisición de conocimientos teóricos y prácticos, optimizar el uso del tiempo en clase, fomentar la autonomía y responsabilidad del estudiante, ofrecer apoyo individualizado, mejorar la planificación y organización de las prácticas y contribuir a una enseñanza más profunda y eficaz. Además, la combinación de vídeos educativos y clase invertida puede crear una dinámica de formación más interactiva y atractiva, aumentando el interés y la motivación de los estudiantes. Esta metodología se ha aplicado a las prácticas de informática de modelos poblacionales de la asignatura Matemáticas, tanto del Grado en Ciencias Ambientales como del Grado en Biología de la Universidad Rey Juan Carlos, reflejando un incremento en el número de aprobados.
A supramodal thorough account of the Molyneux question
Authors: Voltolini Alberto , Calzavarini Fabrizio
Published: November 2024

In this paper, we want to tackle the Molyneux question thoroughly, by addressing it in terms of both ordinary perception and pictorial perception: if a congenitally blind person recovered sight, could she recognize visually the 3D shapes she already recognized tactilely, both when such shapes are given to her directly and when they are given to her pictorially, i.e., as depicted shapes? We want to claim that empirical evidence suggests that the question can be positively answered in both cases. For in the first case, such evidence shows that perception of 3D shapes is supramodal; namely, it can be equivalently achieved in different sense modalities, notably touch and vision, independently of the sensory input such shapes are accessed. While in the second case, such evidence shows that one can satisfy both in vision and in touch the condition for depicted shapes, which are typically not where the perceiver is, to be grasped by that perceiver in a picture’s subject, i.e., what the picture presents. This condition states that the picture’s vehicle, i.e., the typically 2D physical basis of a picture, is enriched by adding to its properties the 3D grouping properties that allow for a figure/ground segmentation to be performed in that vehicle’s elements.
The seven-dimensional universe
Authors: Kesanasetty Sasidhar
Published: November 2024

This paper elucidates the concept of dark energy and the acceleration of the universe through the quantization of space in hidden dimensions, which provides the foundation for gravitational force. Space-time is conceptualized as a four-dimensional elastic grid within a seven-dimensional universe, wherein matter expands concurrently with the universe. Each cube of the grid is considered a quantum of hidden three-dimensional space of Planck volume containing Planck charge, rendering the universe seven-dimensional. The phenomenon of dark energy is attributed to the electrostatic repulsion between Planck charges in each quantum of the hidden space, and the corresponding energy density is correlated with the Hubble parameter H(z), which accounts for the accelerated expansion of the universe and the increase in the relative cosmological potential energy/rest mass of matter. The expansion of space-time is posited to result not from the creation of new space but from the stretching of existing space-time, analogous to an elastic ruler where proper length and volume remain constant. The relative values of the Planck constant, gravitational constant, permittivity of free space, and Boltzmann constant are demonstrated to vary due to the expansion or contraction of space in cosmological and gravitational frameworks, but are compensated for by the proportional change in the relative rest mass. This theory also establishes a framework for the relativistic Newtonian theory of gravity, the respective MONDian (Modified Newtonian dynamics) gravity, identifies a rationale for the transition of Newtonian gravity to MOND at a0, and elucidates the dynamics of galaxy clusters without invoking dark matter.
Italy in Libya (2011-2019): Defending National Interests
Authors: Lumeno Flavia De Lucia
Published: November 2024

The fall of the Gaddafi regime in Libya in 2011, following the Arab Springs, and the subsequent outbreak of civil war with international intervention, has highlighted the different aims of the world players involved in the affair.This article analyses Italy's position on the issue, highlighting that Rome's diplomatic, economic, and military actions towards Tripoli are guided by the defense of national interests, with continuity in energy supplies as a top priority.
The Impact of Online Learning on the Learning Interest of Students at Anak Bangsa Christian High School in Surabaya
Authors: Rumiyati Rumiyati , Kusumanigrum Aprilia Dyah , Purba Nursenta Dahliana , Binar Sri
Published: November 2024

Learning interest is an internal drive that motivates individuals to learn something willingly and without coercion, leading to optimal learning outcomes. Online learning, on the other hand, refers to the teaching and learning process conducted without face-to-face interaction, supported by internet access and technological devices such as smartphones, laptops, or computers. The implementation of online learning during the pandemic has had varying effects on students' learning interest. This study aims to determine whether online learning influences the learning interest of students at Anak Bangsa Christian High School in Surabaya and to measure the extent of its impact. A quantitative method was employed in this research, with data collected through questionnaires completed by 60 respondents, representing the student population of Anak Bangsa Christian High School. The findings indicate a positive correlation between online learning and the learning interest of these students. The study reveals that students' learning interest increased with the enhancement of online learning methods. The contribution of online learning to shaping the learning interest variable among students at Anak Bangsa Christian High School in Surabaya was 57.5%. The study concludes that well-structured online learning can have a positive impact on students' learning interest. Online learning, when implemented interactively and creatively and supported by appropriate resources, can serve as an alternative learning system for the future, allowing students to more easily pursue study programs aligned with their talents and interests.
A Sociological-Ideological Approach to Interpreting 1 Corinthians 7:1-11: The Perspective on Marriage in the Corinthian Church
Authors: Raulina Raulina
Published: November 2024

This article discusses the sociological-ideological interpretation of 1 Corinthians 7:1-11, where Paul responds to the Corinthians' questions regarding marriage and celibacy. In this analysis, the social and ideological context of Corinthian society serves as the basis for understanding Paul's views. By considering the moral conditions and social structure of Corinth, the article examines how the local worldview influenced the interpretation of the text, as well as how the biblical text impacts the social life of the church. The research findings indicate that Paul's decisions about marriage and celibacy were not based on absolute principles, but rather on the specific sociological circumstances in Corinth at the time. Paul's perspective on marriage is also closely related to the Christian teaching on the sacred relationship between Christ and His church. This article emphasizes the importance of considering the social context when interpreting biblical texts, particularly in understanding issues related to family and personal relationships within the church community.
Rapid Onsite Evaluation: A Prospective Observational Study of Endobronchial Ultrasound-Guided Transbronchial Needle Aspirates to Expedite Diagnosis
Authors: Mercer Carolyn , Brackenborough Kate , Davidson Colette , Nisar Tosia , Shambayati Behdad , Cunningham Rupinder , Howarth Ben , Jayadev Anita
Published: November 2024

Biomedical scientists (BMS) can report sample adequacy during EBUS TBNA using rapid on-site evaluation (ROSE). Despite being able to report exfoliative samples such as pleural fluid cytology and bronchial washings, they are usually not permitted to offer a preliminary diagnostic impression of EBUS TBNA samples. Experienced biomedical scientists can provide a reliable diagnostic impression during ROSE for EBUS samples, with sensitivity and specificity comparable to cytopathologist reporting. This work represents an advance in biomedical science because it provides evidence a BMS can safely and accurately provide a real time cytopathological impression from EBUS TBNA sampling, which could positively impact patient pathways.
Risk factor assessment and microbiome analysis in peritoneal dialysis-related peritonitis reveal etiological characteristics
Authors: Zhang Li , Zhang Hongrui , Su Sensen , Jia Ye , Liang Chenyang , Fang Yuan , Hong Dengwei , Li Tianyu , Ma Fuzhe
Published: November 2024

Background

Peritoneal dialysis-related peritonitis (PDRP) is one of the most common complications of peritoneal dialysis (PD). Understanding the risk factors and etiological characteristics is indispensable for infection prevention and improving the outcome and life quality.

Methods

A total of 70 PD patients were separated into the PDRP group (n=25) and the control group (n=45). Variables, including gender, age, body mass index, primary diseases, and history of basic diseases, in the two groups were analyzed to assess the risk factors of PDRP. Metagenomic next-generation sequencing (mNGS) and microbial culture were compared in detecting pathogenic microorganisms. Gut microbiota analysis was performed in 35 PDRP patients based on mNGS data.

Results

Dialysis time and times of dialysate change were the risk factors of PDRP, and times of dialysate change was the independent risk factor of PDRP (p = 0.046). mNGS produced higher sensitivity (65.79%) than microbial culture (36.84%) in identifying pathogenic microorganisms. Staphylococcus aureus and Klebsiella pneumoniae (four cases) were the most frequent pathogens causing PDRP, followed by Staphylococcus capitis (three cases). β diversity of the gut microbiota was significantly different between patients with fewer times of dialysate change (≤4) and more (>5), as well as between patients with gram-positive (G+) bacterial and gram-negative (G−) bacterial infection.

Conclusion

The dialysis time and times of dialysate changes not only are risk factors for peritonitis in PD patients but also stimulate significant changes in the gut microbiome structure in PDRP patients. These findings may provide a novel viewpoint for the management of patients with PDRP.
Commonly encountered symptoms and their management in patients with cirrhosis
Authors: Philips Cyriac Abby
Published: November 2024

This exhaustive review, explored the multifaceted symptoms and their management in patients with cirrhosis. Patients frequently endure pain, muscle cramps, sleep disturbances, psychological distress, and gastrointestinal issues, significantly impairing their quality of life. Pain is prevalent, often requiring analgesics, while muscle cramps affect up to 68% of patients, treated with supplements like zinc and taurine despite limited evidence. Sleep disturbances, including insomnia and excessive daytime sleepiness, afflict up to 80% of patients, managed through lactulose, melatonin, and cognitive behavioral therapies. Gastrointestinal symptoms, affecting 80%, include abdominal pain and bloating, necessitating lifestyle and dietary adjustments. Mental health disorders, such as depression and anxiety, are common, managed with a combination of pharmacotherapy and psychotherapy. Sexual dysfunction, often overlooked, profoundly impacts both men and women, requiring holistic treatment approaches. Pruritus, another distressing symptom, is managed with moisturizers and antihistamines, though many treatments show limited success. Hair loss and skin changes add to the psychological burden, highlighting the need for a comprehensive, multidisciplinary approach. The review underscores the imperative for tailored, compassionate care to enhance patient outcomes and quality of life in cirrhosis.
Staphylococcus lugdunensis: an unusual cause of relapsing hematogenous septic arthritis of a native knee. Case report and review of the literature
Authors: Wery Alexandre-Raphael , Taghavi Maxime , Nortier Joelle , Mahadeb Bhavna , Raftakis Ioannis , Maillart Evelyne , Clevenbergh Philippe
Published: November 2024

Staphylococcus lugdunensis is a facultatively anaerobic gram-positive cocci of the coagulase-negative staphylococcus (CoNS) species. Initially considered as commensal, S. lugdunensis has been found to be responsible for a wide range of disseminated infections in humans (bacteriemia, foreign-body infection, endocarditis, arthritis, osteomyelitis, …) thereby often compared to Staphylococcus aureus in terms of virulence behavior. We present the case of a 62-year-old woman with end-stage renal disease, undergoing hemodialysis through an arteriovenous fistula (AVF) of the left forearm. She was diagnosed with S. lugdunensis bacteriemia and secondary native-knee septic arthritis. Endocarditis was ruled out and the patient evolved well with a 6-week course of IV cefazolin. Four months later, she consulted the rheumatology department with a recurrent right knee arthritis. Cultures came back positive for an identical multi-sensitive S. lugdunensis. Endocarditis was ruled out and full body 18F-FDG PET-CT showed no secondary location but a focal hypermetabolic activity in the left forearm fistula area. AVF Doppler showed no sign of collection nor thrombophlebitis around the fistula. We concluded in an infection of the fistula due to repeated punctures (recurrent cannulation) as entry point. She was treated with a 12-week oral combination of ciprofloxacin and trimethoprim-sulfamethoxazole, and her symptoms have not returned since. S. lugdunensis commonly causes prosthetic and arthroscopy-related joint infections. As native-joint septic arthritis is unusual, we conducted a review of the literature and discuss the burden of disseminated S. lugdunensis infections among dialysis patients.
Virus-specific Dicer-substrate siRNA swarms inhibit SARS-CoV-2 infection in TMPRSS2-expressing Vero E6 cells
Authors: Jiang Miao , Laine Larissa , Kolehmainen Pekka , Kakkola Laura , Avelin Veera , Väisänen Elina , Poranen Minna M. , Österlund Pamela , Julkunen Ilkka
Published: November 2024

After 4 years of the COVID-19 pandemic, SARS-CoV-2 continues to circulate with epidemic waves caused by evolving new variants. Although the rapid development of vaccines and approved antiviral drugs has reduced virus transmission and mitigated the symptoms of infection, the continuous emergence of new variants and the lack of simple-use (non-hospitalized, easy timing, local delivery, direct acting, and host-targeting) treatment modalities have limited the effectiveness of COVID-19 vaccines and drugs. Therefore, novel therapeutic approaches against SARS-CoV-2 infection are still urgently needed. As a positive-sense single-stranded RNA virus, SARS-CoV-2 is highly susceptible to RNA interference (RNAi). Accordingly, small interfering (si)RNAs targeting different regions of SARS-CoV-2 genome can effectively block the expression and replication of the virus. However, the rapid emergence of new SARS-CoV-2 variants with different genomic mutations has led to the problem of viral escape from the targets of RNAi strategy, which has increased the potential of off-target effects by siRNA and decreased the efficacy of long-term use of siRNA treatment. In our study, we enzymatically generated a set of Dicer-substrate (D)siRNA swarms containing DsiRNAs targeting single or multiple conserved sequences of SARS-CoV-2 genome by using in vitro transcription, replication and Dicer digestion system. Pre-transfection of these DsiRNA swarms into Vero E6-TMPRSS2 cells inhibited the replication of several SARS-CoV-2 variants, including the recent Omicron subvariants BQ.1.1 and XBB.1.5. This in vitro investigation of novel DsiRNA swarms provides solid evidence for the feasibility of this new RNAi strategy in the prevention and treatment of SARS-CoV-2 infection.