bluuebunny/crossref_metadata_2025 huggingface dataset:
Targeting ErbB and tankyrase1/2 prevent the emergence of drug tolerant persister cells in ALK fusion positive lung cancer
Authors: Yoshiura Shigeki , Fujimura Takaaki , Furugaki Koh , Mizuta Hayato , Nishio Makoto , Uchibori Ken , Miyauchi Eisaku , Hayashi Hidetoshi , Katayama Ryohei
Published: September 2023

Targeting the drug tolerant persister (DTP) state in cancer cells should prevent further development of resistance mechanisms. This study explored combination therapies to inhibit alectinib-induced DTP cell formation from anaplastic lymphoma kinase–positive non-small cell lung cancer (ALK+ NSCLC) patient–derived cells. After drug-screening 3114 compounds, pan-HER inhibitors (ErbB pathway) and tankyrase1/2 inhibitors (Wnt/β-catenin signaling) emerged as top candidates to inhibit alectinib-induced DTP cells growth. We confirmed knockdown of both TNKS1/2 in DTP cells recovered the sensitivity to alectinib. Further, our study suggested knockdown of TNKS1/2 increased stability of Axin1/2, which induced β catenin degradation and decreased its nuclear translocation, thereby suppressing transcription of antiapoptotic and proliferation-related genes (survivin, c-MYC). Targeting both pathways with alectinib+pan-HER inhibitor and alectinib+TNKS1/2 inhibitor suppressed alectinib-induced DTP cells, and the triple combination almost completely prevented the appearance of DTP cells. In conclusion, combination with ALK-TKI, pan-HER and TNKS1/2 inhibitors prevents the emergence of DTP in ALK+ NSCLC.
Magnetic Activity Cycle Detection Based on Multiple Random Spectral Observations
Authors: Shen Yu-Fu
Published: September 2023

The solar magnetic activity cycle has a profound impact on our lives, yet its underlying causes remain elusive. While similar cycles have been observed in other stars, these results are scarce due to the significant challenge posed by the length of time required for observation. Continuous observation over an extended period is a luxury, making it difficult to gather large samples. However, multiple random observations can be made at a lower cost, and flexible time management enables non-professionals to become competent. In this study, new magnetic activity cycle candidates are identified by utilizing multiple random observations of S-indices of several stars that were accidentally discovered by the Large Sky Area Multi-Object Fiber Spectroscopic Telescope. The S-index observation is less challenging, suggesting that specialized commercial small equipment may be designed, then sold, or distributed to the public.
Simulation experimental investigations into material removal mechanism of SiC ceramic by using drilling-grinding composite machining
Authors: Liu Yin , Chen Jiahao , Sun Xingwei , Dong Zhixu , Yang Heran , Zhao Hongxun , Mu Shibo , Zhang Weifeng , Gong Yadong , Liu Weijun
Published: September 2023

To investigate the machining mechanism of silicon carbide (SiC) ceramic materials, this study utilized sintered diamond tools to perform drilling and grinding simulations on the material, and developed a drilling model for SiC ceramic materials. By analyzing parameters such as surface morphology, stress, and cutting force, the material removal mechanism of SiC ceramic materials was revealed, and the effects of drilling parameters on cutting force, torque, and residual stress were studied. Experimental results indicate that during the abrasive cutting process, the hard contact behavior of irregular abrasive grains significantly affects material removal, leading to failure forms such as chip collapse, hole and groove cracking, and crack propagation. With an increase in the feed rate of the abrasive grains, the drilling force shows a certain range of growth patterns. The axial force is positively correlated with spindle speed and feed rate, with the feed rate having a more significant impact on the magnitude of the axial force. Additionally, as the feed rate increases, the torque also increases. The radial residual stress mainly manifests as residual tensile stress.
Morphology and SSR markers reveal the genetic diversity of Elymus species germplasm in northwestern China
Authors: Zhang Qiang , Li Shucheng , Guo Shuhong , Tian Hongling
Published: September 2023

The relationship between the genetic diversity and genetic characteristics of wild plant germplasm can provide insights for better utilization and conservation of genetic resources. Bunchgrass species in the genus Elymus are important for forage and grassland restoration in Northwest China. In this study, eight phenotypic traits were evaluated in 81 accessions of four Elymus species in the northwest region of China, and genetic diversity analysis was performed using 16 simple sequence repeat (SSR) markers. In the phenotypic trait analysis, Elymus sibiricus had the highest coefficient of variation for single-plant weight(58.24%) and the lowest coefficient of variation for the number of spikelets(0.005%). Clustering based on phenotypic traits placed all varieties into four groups, which were also supported by principal component analysis (PCA). 16 pairs of SSR markers were screened with high polymorphism, with a polymorphism information content (PIC) range of 0.3648–0.7794 and an interspecific PIC range of 0.465–0.611 in Elymus species. The unweighted pair-group method with arithmetic mean approach applied to SSR marker data also divided the 81 accessions into four groups, similar to the results based on phenotypic traits. The results of PCA and population structure analysis based on SSR data were similar. The findings presented here will facilitate the collection and conservation of Elymus germplasm resources and provide theoretical references for the future classification, breeding, innovation, utilization, and conservation of germplasm.
Mechanism of Nardostachyos Radix et Rhizoma (NRER)-Salidroside in the Treatment of Premature Ventricular Beats Based on Network Pharmacology and Molecular Docking
Authors: Liu Shuyuan , Chen Haoyu
Published: September 2023

Objective
To analyse the mechanism of NRER-Salidroside in the treatment of premature ventricular tachycardia by using network pharmacology and molecular docking and to provide the basis for developing the use of clinical traditional Chinese medicine.
Method
The chemical compositions of NRER and salidroside were determined, and their related targets were predicted. The disease-related targets were obtained by searching the common disease databases Genecards, OMIM and TTD, and the intersection between the predicted targets and the disease targets was determined. Then, the STRING database was used to set up a network of protein‒protein interactions (PPIs) between NRER and salidroside and the common targets of PVB and establish a network of PPIs.
Result
Forty-one active components of NRSR-Salidroside were detected, with 420 potential targets of action, with a total of 1688 PVB targets, and the top 10 core targets of drug-disease degree values were AKT1, TNF, GAPDH, SRC, PPARG, EGFR, PTGS2, ESR1, MMP9, and STAT3. KEGG analysis indicated that its mechanism may be related to the calcium signalling pathway, cancer signalling pathway, AGE-RAGE signalling pathway and other pathways. Molecular docking suggested that most of the active ingredients of the NRSR-salidroside pairs were well bound to the core targets.
Conclusion
Based on novel network pharmacology and molecular docking validation research methods, we revealed for the first time the potential mechanism of salidroside in PVB therapy.
Mercury biomagnification in the food chain of a piscivorous turtle species (Testudines: Chelidae: Chelus fimbriata) in the Central Amazon, Brazil
Authors: Cunha Fábio Andrew G. , Forsberg Bruce R. , Vogt Richard C. , Domingos-Moreira Fabíola X.V. , Marshall Bruce G. , Brito Brendson C. , Sousa Otávio P. , Kasper Daniele , Santos Ana Laura , Andrade Marcelo Costa
Published: September 2023

Turtles are an excellent biological model for studies of heavy metal contamination due to their natural history and ecological attributes. Turtles have a large geographical distribution, occupy different aquatic habitats, and pertain to various trophic levels. The present study investigated mercury bioaccumulation in the carnivorous chelonian Chelus fimbriata (Matamata turtle) and Hg biomagnification in relation to its aquatic food chain in the middle Rio Negro, Amazonas, Brazil. Tissue samples of muscle, carapace (shell) and claws were collected from 26 C. fimbriata, and autotrophic energy sources found in the turtle’s aquatic habitat area. In addition, samples of dorsal muscle tissue were collected from 7 Cichla. The samples were collected in February-March of 2014 and analyzed for THg concentrations and carbon (δ13C) and nitrogen (δ15N) stable isotopes. The highest THg concentrations were found in claws (3780ng.g-1), carapace (3622ng.g-1) and muscle (403ng.g-1), which were found to be significantly different (F(2.73)=49.02 p<0.01). The average δ13C and δ15N values in Matamata samples were 11.9‰ and -31.7‰, respectively. The principal energy source sustaining the food chain of C. fimbriata was found to be plankton and periphyton, while δ15N values showed its trophic position to be 3 levels above the autotrophic energy sources. There was a positive correlation between THg concentrations and turtle size, while a significant relationship was found between THg and δ15N, showing strong biomagnification in the food chain of C. fimbriata y=0.13x+0.97; r²=0.31). However, total mercury concentrations found in Matamata turtles were below the consumption threshold indicated by the WHO and Brazilian Health Ministry.
Influence of a succinimide dispersant on the tribological performance of MoS2 nanoparticles
Authors: Benmansour Marina , Afanasiev Pavel , Galipaud Jules , Vacher Beatrice , Trillaud Victor , Joly-Pottuz Lucile , Dassenoy Fabrice
Published: September 2023

In this study, the effect of a polyisobutenyl succinimide (PIB) dispersant on the tribological performances of MoS2 nanoparticles used as lubricant additives in a PAO base oil was investigated. Friction tests were conducted in boundary lubrication regime, in a steel/steel sliding contact configuration, at room temperature and 100°C. The tribofilms formed on the rubbed surfaces were analyzed using X-ray Photoelectron Spectroscopy (XPS) and Transmission Electron Microscopy (TEM). The results show that the dispersant used in this work prevent the agglomeration/sedimentation of the nanoparticles and strongly improves their dispersion in the base oil. Its effect on the tribological performance of the nanoparticles was found to be temperature dependant. The best friction reducing properties were obtained at high temperature. It was also found that the dispersant strongly affects the tribofilm properties (chemical composition, thickness, MoS2 flake length…) and that the best reducing friction properties were obtained when long and scarcely MoS2 flakes aligned in the sliding directions compose the tribofilm.
Exploration of potent phosphate solubilizing bacteria with evaluating pesticide, heavy metal and antibiotic - resistant properties for application as biofertilizer
Authors: Sarkar Balaram , Bhakta Jatindra Nath
Published: September 2023

The present study aimed to explore the potent phosphate solubilizing bacteria (PSB) from the rhizosphere by isolation, screening and characterization to apply as P biofertilizer for improving the plants growth. Due to exhibiting the higher inorganic P solubilization (163.75–245.49 mg/l) property, four isolates (KUJ1PSB1, KUJ1PSB2, KUJ1PSB10 and KUJ1PSB12) were chosen as the potent PSB from a total of fourteen hollow zone exhibiting colonies grown on Pikovskaya’s agar media. Of four isolates, KUJ1PSB2 showed the highest inorganic P solubilization (245.49 ± 0.59 mg/l, 24.97–37.30%) and excellent plant (Solanum lycopersicum) growth promotion (shoot length − 30.43% and leaf number − 50%) efficiencies along with other favourable biochemical properties; indole acetic acid (IAA) production (96.06 µg/ml), pesticide-resistant (50–2000 mg/l), antibiotic-resistant (< 10 - >1000 mg/l), heavy metal -resistant (> 2000 mg/l) and -removal (Cd 93.1%, Zn 53.6%, Pb 72%, and Cu 49%). High P solubilization and IAA production efficiencies of KUJ1PSB2 are important factors for excellent plant growth. Therefore, KUJ1PSB2 was selected as the best PSB among four potential isolates and identified by the 16S rDNA sequencing. The 16S rDNA (1000 bp) sequence of KUJ1PSB2 showed 98.81% similarity with Serratia marcescens and a phylogenetic analysis revealed its position among the related species, which collectively identified it as Serratia marcescens KUJ1PSB2 strain. Finally, it can be concluded that Serratia marcescens KUJ1PSB2 would be a potential P solubilizing biofertilizer for applying in practical fields to produce sustainably higher rate of crop at low-cost through the organic agriculture practices and food production for the benefit of the farmers.
Determinants of Plant Species Richness Along Elevational Gradients: Insights with Climate, Energy and Water-Energy Dynamics
Authors: Kumar Abhishek , Patil Meenu , Kumar Pardeep , Singh Anand Narain
Published: September 2023

Understanding the patterns and processes of species distributions has long remained a central focus of biogeographical and ecological research. While the evidence for elevational patterns in species richness is widespread, our understanding of underlying causes and mechanisms remained limited. Therefore, this study aimed to entangle the influence of environmental variables on plant species richness along elevational gradients in the Western Himalayas. We compiled elevational distribution for about 1150 vascular plants using the published literature and available database. The species richness was estimated in 100-m elevational bands using the range interpolation method. We used the generalised linear model and structural equation modelling (SEM) framework to identify the direct and indirect effects of climatic factors on species richness. Our results indicated that primary environmental correlates of species richness varied with elevational gradients. Climatic variables combined with energy and water availability were more important than the topographic heterogeneity, suggesting that species richness is shaped by climatic tolerances rather than habitat diversity at larger scales. Further, the direct effects of climatic variables were more substantial than their indirect effects, indicating that climate directly influences metabolism and physiology. The indirect effects of climate are more mediated by water–energy dynamics than the energy alone. Overall, our findings emphasise the importance of considering direct effects and interactions among environmental variables while studying the underlying mechanisms governing elevational biodiversity gradients.
Longitudinal Patient-Reported Outcomes after Minimally Invasive McKeown Esophagectomy for Patients with Esophageal Squamous Cell Carcinoma
Authors: Miao Yan , Nie Xin , He Wen-Wu , Luo Chun-Yan , Xia Yan , Zhou Ao-Ru , Wei Si-Rui , Wang Cheng-Hao , Fang Qiang , Peng Lin , Leng Xue-Feng , Han Yong-Tao , Luo Lei , Xie Qin
Published: September 2023

Purpose
Surgery for esophageal squamous cell carcinoma (ESCC) is characterized by a poor prognosis and high complication rate, resulting in a heavy symptom burden and poor health-related quality of life (QOL). We evaluated longitudinal patient-reported outcomes (PROs) to analyze the correlations between symptoms and QOL and their changing characteristics during postoperative rehabilitation.
Methods
We investigated patients with ESCC who underwent minimally invasive McKeown esophagectomy at the XXX between April 2019 and December 2019. Longitudinal data of the clinical characteristics and PROs were collected. The MD Anderson Symptom Inventory and European Organization for Research and Treatment of Cancer (EORTC) QOL questionnaires were used to assess symptoms and QOL and compare the trajectories of PROs during the investigation.
Results
A total of 244 patients with ESCC were enrolled in this study. Regarding QOL, role and emotional functions returned to baseline at 1 month after surgery, and cognitive and social functions returned to baseline at 3 months after surgery. However, physical function and global QOL did not return to baseline at 1 year after surgery. At 7 days and 1, 3, 6, and 12 months after surgery, the main symptoms of the patients were negatively correlated with physical, role, emotional, cognitive, and social functions and the overall health status (P < 0.05).
Conclusion
Patients with ESCC experience reduced health-related QOL and persisting symptoms after minimally invasive McKeown esophagectomy, but a recovery trend was observed within 1 month. The long-term QOL after esophagectomy is acceptable.
Histopathological Study and Immunohistochemistry of Mediastinal Masses of Anterior Compartment
Authors: Vemuluri Mounica , Philipose Thoppil Reba
Published: September 2023

Background: The mediastinum is the mid portion of the thoracic cavity, further divided into the anterior, middle, and posterior mediastinum. The numerous organs within the mediastinum make it prone to the development of various lesions. About half of all mediastinal masses occur in the anterior compartment. The most common are thymoma, lymphoma and mature teratoma. An accurate histopathological diagnosis is required for the management of mediastinal lesions.

Methods: This is a 2-year prospective study conducted in the Department of Pathology on Biopsies and Resected Specimens of Anterior Mediastinal Masses (AMM) in a tertiary care hospital from September2020-September2022. Sections were studied after staining with hematoxylin and eosin(H&E). Immunohistochemical (IHC) stains were done wherever required.

Result: The present study included 58 cases of AMM. The age of the patients ranged from 2-77 years. Males constituted 68.90 % of cases. The male-to-female ratio was 5:2.2. Cough was the most common presenting symptom. Thymic pathology was detected in 56.8% of cases, of which thymoma is the most common. Thymoma presented with Myasthenia Gravis (M.G.) in 2 cases. Lymphoma constituted 12% of cases. Metastatic carcinoma in 12%, Extragonadal Germ Cell Tumor (EGCT) in 8.6% and lymphangioma in 3.4% cases. Lipoma, sarcoidosis and myofibroblastic tumor each constitute 1.72% cases.

Conclusion: The present study describes the various lesions of the anterior compartment.
Incidence Of Hemoglobinopathies In South Indian Population – 4 Year Study
Authors: A Kavitha - , V Kavita , . Mukilarasi
Published: September 2023

Background

Hemoglobinopathies are very common, but majority being asymptomatic it is under diagnosed. Hemoglobinopathies are important health care threat in tropical countries. The present study analyzed the incidence of hemoglobinpathies in south Indian population reported in regional laboratory in Chennai catering Tamil nadu and Andhra Pradesh population.

Methods

A cohort of samples which was received for abnormal hemoglobinopathy studies for evaluation of anemia and prenatal screening from Tamil nadu and Andrapradesh population for 4 years was analyzed using capillary electrophoresis method in (Sebia Minicap instrument) for incidence of hemoglobinopathies.

Result

Total number of cases studied during 4 years (2018-2022) is 17678, Of which 1194(7%) were detected with hemoglobinopathy/ abnormal hemoglobin variant.  Of which 56.28% were female and 43.72% were male. Common age group under study is 21-30(30.07%). Beta thalassemia trait was detected at the highest frequency (69.13%) followed by HbE-Beta thalaseemia(6.87%) and least being HbD homozygous.

Conclusion

Our study analyzed a cohort and reported a spectrum of hemoglobin variants and its incidence in Tamil nadu and Andhrapradesh population.
Analysis of Contractor-Related Delay Factors in Building Construction
Authors: S. Sangeetha M. , Thomas Anu V.
Published: September 2023

The unforeseen circumstances which can lead to delays are one among the most significant issues in the construction business. Listing the reasons for these delays is important to minimize and improve construction quality, time, and financial management. This will facilitate the on-time completion of the project. This research concentrates entirely on contractors' influence in these delays. Contractors, engineers, project managers, and civil engineers were asked for feedback on how to prioritize the identified elements. Overall results showed that labour shortages, material shortages, contractor financial problems, subcontracting problems, inaccurate time and cost estimates by contractors were major concerns.
Seismic Performance of Multistoried Building Frames with Unbonded Scrap Tyre Pad Isolators
Authors: Mathew Ancy , R. Sajeeb
Published: September 2023

Base isolation is one of the most powerful tools for earthquake protection of structures. The huge cost of conventional isolators makes them unaffordable for developing countries. The Scrap tyre pad isolator is an emerging low-cost technology for the seismic protection of structures. The tread portion of tyre can be cut into pads of definite size and arranged one above the other to form the isolator. In the present study, a G+7 storied structure isolated with scrap tyre pad isolators was analyzed using the response spectrum method in ETABS. The performance was also compared with that of conventional lead rubber bearings in terms of lateral displacement, drift ratio, storey accelerations, base shear and time period. The analysis results show that scrap tyre pad isolator is also effective in seismic protection of structures.
Pullout Behaviour of Steel Under Different Types of Concrete Composites
Authors: Behanan Sunil C. , R. Bindhu K. , A. Adithya D.
Published: September 2023

In reinforced-concrete members adequate bond strength between reinforcing bars is necessary to guarantee full composite action. The present study involves the analysis of bond strength by conducting pullout test on deformed steel rebar embedded in various types of concrete such as normal concrete, engineered cementitious composite (ECC) and glass powder concrete (GPC). ECC has ductility due to presence of fibre which prevents development of internal cracks, and it has more compatible deformability with steel rebar. The bond between concrete and steel is not uniform and differ with different loading condition. Other factors like mechanical interlocking, adhesion between concrete and steel also contribute to bond. Earthquake forces causes reversal of load and hence at lap joints it can cause slip of the joints if sufficient anchorage length is not given. Pullout studies were conducted to assess the bond characteristics of concrete and steel using cube and cylindrical specimens as per the current standards/codes. The bond slip behavior acquired from the pullout test using the software "ANSYS" were equated with the experimental results. The bond strength of ECC and GPC are more compared to that of M30 using same strength of concrete composites. All load-slip curves have mostly the same trend for M30, GPC and ECC. Comparison of numerical results with experimental results gave less than 6% error for concrete composites. From both experimental and numerical studies, failure is more critical at the interface region of concrete composites and steel bar.
Harpasa Antik Kenti ve Yakın Çevresinden Antik Döneme Ait Taş Onarımları
Authors: YAŞAR Ali
Published: September 2023

Arkeolojik alanlarda sistematik kazı çalışmaları ile açığa çıkarılan yapılara ait taş unsurlar incelendiğinde, yapıların inşa süreçleri ve sonraki dönemlerde geçirmiş oldukları onarımlar hakkında önemli ipuçları elde edilmektedir. Daha çok tamamlamaları şeklindeki antik dönem onarımları incelendiğinde uygulamaların kendi içerisinde gerek bezemenin işlenişi gerekse de eski ve yeni malzemeyi birbirine bağlayan malzemeler konusunda farklılıklar olduğu anlaşılmaktadır. Özellikle malzemeler konusundaki çeşitliliklerin tanımlanması ve buna göre taş onarımlarının kendi içerisinde sınıflandırılması, antik dönem taş onarımlarının anlaşılabilmesi açısından önemlidir. Antik dönemde taş onarımları, farklı nedenlerden dolayı yapılıyordu. Mimari yapıların inşa sürecinde, oluşan lokal deformasyonlar, antik dönemde meydana gelen büyük boyutlu depremler, vandalizm, savaş ve baskınlar vb. nedenler yapı onarımlarını zorunlu hale getirmektedir. Ayrıca geç antik çağda farklı yapılara ait kullanım dışı durumundaki malzemelerin yapı onarımlarında devşirme olarak kullanıldığı örnekler, yine onarımlarla ifade edilebilir. Bu çalışmada, Aydın İli, Nazilli İlçe merkezindeki Sümer Basma Sanayi Fabrikası Yerleşkesinde bulunan mimari yapı elemanları arasındaki iki örnekte antik yapı onarım pratiklerine rastlanmıştır. Bir diğer antik onarım örneği ise Nazilli’nin güneyindeki Esenköy sınırları içerisinde yer alan Harpasa antik kentindedir. Kenti çevreleyen Arkaik Dönem sur duvarlarında Bizans Dönemi’nde yapılmış onarım izleri bulunmaktadır. Örnekler, antik onarımlar açısından incelendiğinde iki farklı onarım tipi ile karşılaşılmıştır. Bunlardan birincisi yapı elemanı bazında gerçekleştirilmiş olup “Aynı taş harçlı bitiştirme” tipi, diğeri ise özgününde kuru duvar tekniği ile örülmüş Arkaik sur duvarında ise “Harç bağlayıcılı Sur duvarı onarımı” tipindedir.
Multi-energy system smart tool for ecological water body restoration using an AI-based decision-making framework
Authors: Xu Shu , Hsu Ching-Hsien , Montenegro-Marin Carlos Enrique
Published: September 2023

Ecological regeneration will reduce air pollution, reverse forest clearing and wilderness, minimize loss of biodiversity, improve urban ecosystems, and probably enhance the livelihoods and ties between mankind and nature. Ecological regeneration risk factors include frequent changes in natural environments, imperfect interpretation of natural systems by humans, and a lack of knowledge on past successes and shortcomings. The Internet of Things (IoT) uses in environmental monitoring are varied: environmental protection, extreme weather monitoring, water safety, conservation of endangered species, and commercial farming. In this paper, artificial intelligence-based environmental decision restoration framework (AI-EDRF) has been proposed to strengthen the continuously evolving natural systems; people are deficient about natural systems and the insufficient knowledge about past achievements and failures. The biological terrestrial collective analysis is introduced to improve natural systems is rapidly evolving, and people are inadequately aware of natural systems. Stochastic water quality analysis is integrated with AI-EDRF to boost past achievements and failures. IoT-enabled smart energy management is an effective approach to provide cost-effective, efficient energy distribution and technologies are used in connection with sustainable, renewable energy sources. The computational analysis is executed based on accuracy, performance ratio, reaction time, and data deployment to verify the developed framework's reliability.
Integrated systems for rainwater harvesting and greywater reuse: a systematic review of urban water management strategies
Authors: Rodrigues A. M. , Formiga K. T. M. , Milograna J.
Published: September 2023

Combined, decentralized systems for rainwater harvesting and greywater reuse may enhance the water security of urban areas by reducing dependence on the main water supply, in particular during critical periods, such as the dry season. They can also minimize the risk of flooding during the rainy season. The present study assesses the accumulated knowledge of these combined systems based on a systematic review of the literature restricted to academic sources. The review revealed knowledge gaps that must be resolved to better assess the optimum combination of rainwater and greywater recovery, how this affects the need for the treatment of the recovered water, its final quality, potential options for reuse, water economy, and the environmental and economic performance of the system. Further empirical studies are required to determine the most adequate design configuration for these systems, considering their multiple objectives, technological perspectives, and in particular, their potential for improving environmental shortcomings. There is a clear need for widespread use of low-impact technologies to ensure the most effective possible results. Water recovery systems will become increasingly important as a means of tackling the challenges of water supplies in the urban landscape, which are being exacerbated by climate change.
Antimicrobial Bacterial Metabolites: Properties, Applications and Loading in
Liposomes for Site-specific Delivery
Authors: Valença Camilla A.S. , Barbosa Ana A.T. , Dolabella Silvio S. , Severino Patricia , Matos Carla , Krambeck Karolline , Souto Eliana B. , Jain Sona
Published: September 2023

The high levels of antibiotic resistance registered worldwide have become a serious health problem,
threatening the currently available treatments for a series of infectious diseases. With antibiotics becoming less
and less effective, it is becoming increasingly difficult and, in some cases, impossible to treat patients with
even common infectious diseases, such as pneumonia. The inability to meet the ever-increasing demand to control
microbial infection requires both the search for new antimicrobials and improved site-specific delivery. On
the one hand, bacterial secondary metabolites are known for their diverse structure and antimicrobial potential
and have been in use for a very long time in diverse sectors. A good deal of research is produced annually describing
new molecules of bacterial origin with antimicrobial properties and varied applications. However, very
few of these new molecules reach the clinical phase and even fewer are launched in the market for use. In this
review article, we bring together information on these molecules with potential for application, in particular, for
human and veterinary medicine, and the potential added value of the use of liposomes as delivery systems for
site-specific delivery of these drugs with the synergistic effect to overcome the risk of antibiotic resistance.
Recent Advances in Nanobiotechnology for the Treatment of
Non-Hodgkin’s Lymphoma
Authors: Liu Shuxian , Xu Minghao , Zhong Lei , Tong Xiangmin , Qian Suying
Published: September 2023

Lymphoma is the eighth most common type of cancer worldwide. Currently, lymphoma is
mainly classified into two main groups: Hodgkin's lymphoma (HL) and non-Hodgkin's lymphoma
(NHL), with NHL accounting for 80% to 90% of the cases. NHL is primarily divided into B, T, and
natural killer (NK) cell lymphoma. Nanotechnology is developing rapidly and has made significant
contributions to the field of medicine. This review summarizes the advancements of nanobiotechnology
in recent years and its applications in the treatment of NHL, especially in diffuse large B cell lymphoma
(DLBCL), primary central nervous system lymphoma (PCNSL), and follicular lymphoma
(FL). The technologies discussed include clinical imaging, targeted drug delivery, photodynamic therapy
(PDT), and thermodynamic therapy (TDT) for lymphoma. This review aims to provide a better
understanding of the use of nanotechnology in the treatment of non-Hodgkin's lymphoma.
A Sustainable Approach Towards Prevention and Treatment of Hepatic
and Other Disorders Associated with Alcohol Consumption
Authors: Nooreen Zulfa , Shukla Ankita , Shukla Anuja , Verma Priyanka
Published: September 2023

Background:

Alcohol has been used for centuries in many different civilizations. It is a
psychoactive stimulant with addictive properties. Alcohol misuse has significant negative social, economic,
and health effects. Abusing alcohol can cause harm to oneself as well as to relatives, coworkers,
close companions, and total strangers. Alcohol usage contributes to more than 200 diseases, accidents,
and other health problems. Drinking alcohol is associated with a higher chance of developing
significant non-communicable illnesses such liver cirrhosis, a number of cancers, cardiovascular diseases,
as well as behavioral and mental disorders like alcoholism.

Objective:

Abuse of alcohol does not occur suddenly. People becoming addicted to various alcoholic
beverages is a problem that results from months and years of irresponsible drinking. The process of
recovering from the issue in turn includes targeted, particular methods for raising awareness of the
negative effects of alcohol usage.

Conclusion:

Due to the heightened risks for one's bodily and mental health along with the social issues
it generates, alcohol consumption results in these costs. We discuss the three areas of the epidemiology
of alcohol's impact on health and diseases, the public health approach for treating problems
related to alcohol use,and advancements in alcohol science.
Multiple Sclerosis: New Insights into Molecular Pathogenesis and Novel
Platforms for Disease Treatment
Authors: Dejbakht Majid , Akhzari Morteza , Jalili Sajad , Faraji Fouziyeh , Barazesh Mahdi
Published: September 2023

Background:

Multiple sclerosis (MS), a chronic inflammatory disorder, affects the central
nervous system via myelin degradation. The cause of MS is not fully known, but during recent
years, our knowledge has deepened significantly regarding the different aspects of MS, including
etiology, molecular pathophysiology, diagnosis and therapeutic options. Myelin basic protein
(MBP) is the main myelin protein that accounts for maintaining the stability of the myelin sheath.
Recent evidence has revealed that MBP citrullination or deamination, which is catalyzed by Ca2+
dependent peptidyl arginine deiminase (PAD) enzyme leads to the reduction of positive charge,
and subsequently proteolytic cleavage of MBP. The overexpression of PAD2 in the brains of MS
patients plays an essential role in new epitope formation and progression of the autoimmune disorder.
Some drugs have recently entered phase III clinical trials with promising efficacy and will
probably obtain approval in the near future. As different therapeutic platforms develop, finding an
optimal treatment for each individual patient will be more challenging.

Aim:

This review provides a comprehensive insight into MS with a focus on its pathogenesis and
recent advances in diagnostic methods and its present and upcoming treatment modalities

Conclusion:

MS therapy alters quickly as research findings and therapeutic options surrounding
MS expand. McDonald's guidelines have created different criteria for MS diagnosis. In recent
years, ever-growing interest in the development of PAD inhibitors has led to the generation of
many reversible and irreversible PAD inhibitors against the disease with satisfactory therapeutic
outcomes.
An RSA-based Secure E-hailing Application
Authors: Jun Hao Loo , Nik Ab Aziz Nik Sakinah , Ain Nik Suki Nik Nurul
Published: September 2023

E-hailing and taxi services play a vital role in the transportation industry. It
inadvertently also provides opportunities for malicious hackers to hack into e-hailing
applications to gain private user information. With the increase in data breaches, there
is a need for an encryption technique to increase the security level and assure the safety
of users’ data. This study proposed SafeCar, a secure e-hailing application using the
RSA algorithm. SafeCar is developed using ASP.NET language. Testing has been done
to evaluate the security, input validation, and user satisfaction. The testing results
showed that 50% had a very good security level, another 50% with a good security
level, 100% user satisfaction, and 67% had very good input validation, with another
33% resulting in good input validation.
Elderly Monitoring Using the Internet of Things (IoT)
Authors: Tan Xian Long Matthew , Binti Kamsin Intan Farahana
Published: September 2023

 As people get older and their bodies weaken, they become more prone to
illnesses and injuries. This paper reviews several research papers that discuss
implementing a monitoring system that monitors the elderly. This research aims to
improve the healthcare and safety of elderly people alone at home by implementing a
monitoring system based on IoT technology in Malaysia. This paper also discusses how
stratified sampling methods and surveys can help identify elderly peoples’ preferences
and improve the monitoring system. The system proposed in this research uses real-time pulse and temperature monitoring, real-time fall detection monitoring, a cloud
database, and a mobile application that could help reduce the effort and worry of taking
care of the elderly. The findings of this research will help to improve the lives of
elderly people that prefer staying in their own homes and will hopefully reduce the
effort needed to take care of them. Future system improvements will include blood
pressure and respiration rate monitoring, allowing more accurate monitoring of their
health.
Analytics on Airline Customer Satisfaction Factors
Authors: Leong Pit Khien , Logeswaran Rajasvaran
Published: September 2023

Dissatisfaction with the services provided causes customer loss and
customer churn in airline companies. Analytics conducted in assessing customer
satisfaction in airline companies and their analytical methods are reviewed to identify
the analysis's strengths, weaknesses, and gaps. Data analytics on assessing customer
satisfaction have been conducted on facilities and services provided, price, service
quality, reviews of customers, and flight catering. However, this research indicates that
only a few in-depth studies consider flight delays as a critical factor influencing
customer satisfaction. A flight is considered delayed if it departs or arrives 15 minutes
later than the scheduled time. Therefore, in this research, further analytics can be done
on the amount of time-of-flight delay in assessing customer satisfaction.
Market Power and Firms' Performance: A Case of Indonesian Manufacturing Industry
Authors:   Faculty of Economics and Business, University of Indonesia, Nurrachmat Janaska
Published: September 2023

Purpose This study aims to investigate the relationship between market power and firms’ performance in the Indonesian manufacturing industry. Design/methodology/approach Using the Statistik Industri Besar dan Sedang from BPS we extract the data about the market share and productivity of each firm that will represent market power and the firms’ performance respectively. The dataset also allows us to apply dynamic panel data that might address the endogeneity and reverse causality problem which could occur in the estimation. Findings The results suggest that market power has an inverted U-shaped relationship with firms’ productivity. Further analysis shows similar conditions also occur in all selected industries except automotive. Research limitations/implications This study could help policymakers if they want to influence firms’ performance based on their market share. Originality/value This paper applies the DPD method to address the endogeneity problem that might occur in the previous studies.
Sensory Characteristics Of Pinogu Coffee From Bone Bolango Gorontalo
Authors:   Universitas Brawijaya., Susilo Bambang , Ciptadi Gatot , Kurniawan Syahrul , Fibrianto Kiki , Putra Samudera Rizki , Shinta Wulandari Eka
Published: September 2023

Pinogu coffee is a superior coffee from the Gorontalo region. Pinogu coffee is a type of robusta coffee. From the results of the research conducted, this Pinogu coffee has sensory characteristics that tend to be bitter (taste and aftertaste) with the aroma of smoke and wood, followed by a burnt and roasted aroma and a slightly thick body or texture that coats the oral cavity. As for the chemical characteristics, ground Pinogu coffee contains a water content of 2.51%, caffeine content of 1.99%, and copper content of 13.86 mg/kg, for steeping the coffee contains a caffeine content of 0.06% and copper content of 0,39 mg/kg
Cluster Analysis Of Marine Toll Service Area To Minimize Price Disparity To Inprove The Economy Of The East Indonesian Region In The Era Of The Covid-19 Pandemic
Authors:   Industrial Engineering, Faculty of Engineering Universitas Brawijaya, Indonesia, Kusuma L. Tri Wijaya N. , Cahyawati Amanda Nur , Sari Sylvie I. Kartika
Published: September 2023

High price disparity is an economic problem that causes the welfare level of the population to be low. The government through the Sea Highway program tries to reduce price disparities through subsidized and scheduled sea transportation to serve several ports in Indonesia, one of which is in the province of Riau Islands. The Strait of Lampa Port is one of the marine transportation nodes which is a stopover point for Sea Toll boats on the T-3 route serving Natuna Regency. This port has the status of a regional feeder port with the hinterland area of Natuna Regency with Ranai as the district capital. This study aims to provide input related to the clustering of the Marine Highway program in Natuna from several perspectives, namely from the potential of regionalcommodities and infrastructure for Sea Toll services in the Natuna region. The analysis method used is descriptive qualitative and comparative. The results showed that for the cluster of the western region of Indonesian waters, in this case represented bya sample of the T-3 Natuna Islands Sea Toll route service, in terms of supply and demand from the homebase of Tanjung Priok Port, it is sufficiently balanced even though there are several superior commodities in the Natuna archipelago that have not yet optimally distributed, due to the low development and increase in added value of commodities. Based on the sample Sea Toll service route that has been selected for the Western Region of Indonesia, namely the T-3 route for the Natuna Islands region, several criteria that need to be considered in the future regarding the Sea Toll service cluster include regional commodities, Port infrastructure facilities and infrastructure, hinterland transportation facilities and infrastructure, and ship type and capacity
Experiencias del profesional de enfermería durante el cuidado al paciente crítico: lecciones autoaprendidas
Authors: Quinatoa Diego , Mejía Mauricio , Herrera Priscila , Muñoz Alisson , Jimenez Barrera Maricelys
Published: September 2023

Patient care should be provided in a favorable environment, considering that it is an attitude endowed with understanding, compassion, awareness and competence, taking into account the essence of the profession. Objective: to analyze the nursing professional's experiences during patient care in critical care units. The approach was qualitative, with descriptive design and a phenomenological approach. Ten participants were considered through non-probabilistic sampling and theoretical saturation. The instrument was the semi-structured interview. The data analysis was carried out through Colaizzi's method. Six categories emerged as a result of the research: experiences of the nursing professional during patient care in critical care units; elements that stand out in the affairs of the nursing professional during patient care in critical care units; repercussions of self-taught learning in the nursing professional; humanized comprehensive care; knowledge of the nursing staff on the management of the critical patient; and increased patient-family-nurse bonding. Final considerations According to the findings, in the nursing professional's experiences, deficiencies are perceived in the communication provided to the patient and family with whom the nursing staff should establish an interpersonal bond. Work overload is an element that influences the quality of care of patients admitted to the ICU.
Keywords: care; humanization; nurse; patient.
Practical recommendations for the use of electronic headache diaries and video consultations in migraine care (Preprint)
Authors: van der Arend Britt WH , Holwerda Linde J , Verhagen Iris E , van Casteren Daphne S , Timmers Thomas , Terwindt Gisela M
Published: September 2023

BACKGROUND

Telemedicine offers promising solutions to enhance personalized headache care. Telemedicine offers a promising solution to enhance the delivery and personalization of headache care. Integrating electronic (E-)tools enables the objective monitoring of migraine.

OBJECTIVE

This study aims to demonstrate the relevance of electronic (E)-tools for personalized headache care, assess patient and caregiver compliance and satisfaction, and present their use in enhancing care.

METHODS

Firstly, a systematic review was performed to validate the diagnostic accuracy of E-diaries for diagnosing migraine. Secondly, we collected E-diary data prospectively from diagnosed adult migraine patients at the Leiden Headache Center. Finally, questionnaires were sent to evaluate satisfaction of patients and healthcare providers with the Leiden E-headache diary and video consultations.

RESULTS

In the systematic review, the Leiden Headache Center's E-diary was the only validated tool. Patients (n=1,009) were followed for a median of 181 days (IQR 84-240). Compliance was 96.4% (IQR 85.2%-99.1%), with 10.8% of days missing. Factors positively associated with compliance were older age, female sex, higher E-diary grade, and clinical use. The E-diary received a median score of 8/10 and was well-liked by patients (n=535) and providers (n=23). Video consultations were a good alternative for physical visits according to 76.9% of patients and 84.6% of providers.

CONCLUSIONS

Validated E-headache diaries and video consultations in telemedicine enhance headache care accessibility, providing convenient care at preferred times and locations.
Pengaruh Pemberian Buah Kurma Ajwa (Phoenix dactilyfera L) terhadap Kadar Hormon Anti-Mullerian (AMH) dan Gambaran Klinis Perempuan Perimenopause
Authors: Mulyadi Farah Ekawati , Natsir Rosdiana , Mappaware Nasrudin Andi , As'ad Suryani , Sinrang Andi Wardihan , Kurniawan Liong Boy
Published: September 2023

Background: Perimenopause is clinically characterized by the appearance of various complaints such as disturbed menstrual cycles, vasomotor symptoms, and mood changes that have an impact on reduced quality of life. The decline in ovarian reserve is thought to be the beginning of this transition which eventually triggers hormonal changes. AMH is used as a marker of ovarian reserve and clinically as a predictive biomarker of menopause. Ajwa dates contain various phytochemicals that have potential to be used to protect primordial follicles from various damage while reducing perimenopause complaints.Objective: This study aimed to analyze the effect of consumption of ajwa dates on AMH levels and clinical features of perimenopausal women.Methods: This quasi-experimental study with a pre-post control design was carried out at RSIA Sitti Khadijah I Muhammadiyah Makassar, South Sulawesi, Indonesia, from May to October 2021. This study involved 44 perimenopausal subjects aged 42-48 years who were divided into 2 groups randomly (28 intervention groups, 16 control groups). AMH levels were checked by ELISA method while the clinical features was assessed by clinical examination.Results and Discussion: AMH levels in the intervention group decreased more slowly than the control group (0.37 ± 0.36 ng/ml vs 0.55 ± 0.19 ng/ml, p<0.05). Complaints of sleep disturbances, vaginal dryness, and mood changes were better in the intervention group (p<0.05), while complaints of irregular menstrual cycles and hot flushes were not significantly different in either control and intervention groups.Conclusion: AMH levels in the intervention group decreased more slowly than in the control group. The clinical features in the intervention group were better than the control group. Ajwa dates can be a good nutrition in improving the quality of life of perimenopausal women.Keywords: Anti-Mullerian Hormone (AMH); Clinical Features; Ajwa Dates; Perimenopause.