bluuebunny/crossref_metadata_2025 huggingface dataset:
Bosque de pinceles
Authors: Tu Fu
Published: July 2023

Tu Fu o Du Fu, es el clásico por antonomasia de los más de treinta siglos de tradición poética china, el primero de los poetas realistas de la dinastía Tang y de toda la historia literaria de China. Las constantes revueltas políticas de su época le dieron ocasión de compartir intensamente el sufrimiento de la gente y de conocer de cerca las ambiciones, injusticias y desenfrenos que están en su origen. Sus poemas se relacionan siempre con su biografía y con la historia que le tocó vivir, es un poeta biográfico, un poeta historiador, un poeta popular. La antología Bosque de pinceles presenta una amplia selección de centenar y medio de poemas, todos ellos de magistral belleza que nos hablan de compasión, paisaje, biografía, naturaleza y reflexión.
Amores adversos y apasionados : la evolución del tema del amor en cinco novelas latinoamericanas
Authors: Ledgard Melvin
Published: July 2023

En la primera de las novelas de las que se ocupa Amores adversos y apasionados, se compara el flechazo amoroso que recibe el protagonista con las cataratas del Niágara; en la última, con un estremecimiento geológico. Cualquiera que lo haya sentido, sabe que hasta estas descripciones parecen quedarse cortas. Por lo menos, en mi propia vida, fue muchas veces una situación que absorbió muchísima energía. Este trabajo fue una manera de ordenar mis ideas sobre el tema, tanto una primera vez a mediados de los noventa, como una segunda, ya en este nuevo milenio.
Las relaciones entre el Perú e Italia (1821-2002)
Authors: Valdez Arroyo Flor de María
Published: July 2023

El presente trabajo está dividido en cinco secciones. La primera cubre los primeros contactos entre los que serían los Estados del Perú e Italia, sucedidos antes de 1821, y hace hincapié en la llegada de los primeros pobladores de la península itálica al Perú; en la consolidación de la influencia italiana en esta parte de América; en la llegada de Carlos III de Borbón, de ascendencia italiana, al trono español; y en el impacto de este último suceso en el virreinato del Perú. La segunda cubre el periodo comprendido entre 1821 y 1870, y en él se aborda la relación de la naciente república peruana con los diversos Estados que se encontraban establecidos en la península itálica hasta su unificación con la creación del reino de Italia en 1861. Esta sección hace énfasis en la emancipación y proclamación de la independencia del Perú, en los avatares de los Estados italianos en su intento por liberarse del dominio austriaco y en el establecimiento de relaciones diplomáticas entre el Perú y algunos Estados italianos antes de la unificación. La tercera se refiere al impacto de la Guerra del Pacífico en la relación entre el Perú e Italia. Este momento es abordado considerando, en primer lugar, la situación de la relación entre el Perú e Italia previa al inicio del conflicto; en segundo lugar, la concreta participación italiana en dicho incidente, tanto en el plano político-diplomático como en el de su comunidad en el Perú; y, en tercer lugar, la forma en que la guerra con Chile influyó concretamente en la relación diplomática entre ambos países. La cuarta está dedicada a la relación bilateral entre el Perú e Italia en el periodo de las dos guerras mundiales. En este capítulo, se estudia por separado los períodos correspondientes a cada uno de esos conflictos bélicos y, también, el periodo que se ubica entre ellos, siempre teniendo en cuenta la actividad diplomática y las tendencias comerciales entre ambos países. Finalmente, la última sección muestra el giro que toma la relación bilateral hacia la cooperación, ya sea ésta técnica, económica, cultural o judicial.
Fábulas y antifábulas
Authors: Silva Santisteban César
Published: July 2023

El libro está dividido en dos secciones. En la primera se reúne el material narrativo, relatos que van desde un par de páginas hasta una novela breve. Casi cada uno de estos cuentos pertenece a un subgénero diferente (fantástico, policial, histórico), pero en todos ellos más importante que el modelo o las anécdotas resulta el juego con los mitos y referentes culturales. En “El exilio”, por ejemplo, se hace un breve y peculiar recuento de la vida de María Magdalena: “cuando adoptó a Jesús ella tenía doce años y él treinta. Ella hilaba en el templo y él decidió, convencido por Juan Bautista, ser el Mesías de su pueblo”. El mejor logrado de estos relatos es “Los invitados de la Última Cena”, una historia en torno a las circunstancias en que el maestro Bernardo (personaje basado en Da Vinci) pintó “La Última Cena”. Una versión previa de este cuento resultó finalista del Premio Copé 2000, pero esta vez se ha desarrollado hasta convertirse casi en una nouvelle (70 páginas), en la que se describen costumbres y creencias de la época. Pero, más que nada, el autor parece deleitarse con la sonoridad y musicalidad del lenguaje, y la recreación de una retórica particular. Hay, en este y otros cuentos, páginas muy bien logradas en las que además se muestra un acertado manejo de las técnicas narrativas. La segunda sección lleva como título “A propósito de...” y está constituida por reflexiones libres que nos hacen recordar las Prosas apátridas de Ribeyro, sobre temas sumamente variados, abordados siempre a partir de citas y referentes librescos, pero también con un cierto aliento poético. Con un libro de ensayos y un poemario previamente publicados, CSS se libera de esquemas genéricos para entregarnos las conversaciones entre el deseo y la voluntad, o “La última carta del doctor Jekyll y la respuesta de su amada”; además de disquisiciones sobre “La ética según Savater”, “Los asesinos posmodernos” o “La necrofilia”.
En busca del orden perdido : la idea de la historia en Felipe Guamán Poma de Ayala
Authors: Ossio Juan M.
Published: July 2023

La historia de la sociedad andina antes de la Conquista ha sido un reto para los investigadores, ya que no existen testimonios directos de la época. Juan Ossio, historiador y antropólogo peruano, aborda este tema en el libro En busca del orden perdido trabajo que fuera presentado por primera vez hace casi treinta y ocho años como su tesis para optar el título de Bachelor Litterae en la Universidad de Oxford. El volumen es la quinta entrega de la Colección de Estudios Andinos dirigida por Marco Curatola y editado por el Fondo Editorial de la PUCP. Esta investigación de Juan M. Ossio, tiene por finalidad entender la representación andina del pasado y contribuir a la crítica histórica sugiriendo una perspectiva distinta. A diferencia de los trabajos pioneros de Tom Zuidema, que son el germen de la obra de Ossio, su aproximación tiene como punto de partida un individuo que puede ser localizado en el tiempo y en el espacio. Al escoger a Guamán Poma, el propósito de Ossio ha sido utilizarlo como informante, tal como sus paisanos o él mismo pudieron ser para los españoles, e interrogarlo sobre su actitud hacia el pasado.
El lenguaje vial : el lenguaje de la vida
Authors: Dextre Quijandría Juan Carlos , Tabasso Carlos
Published: July 2023

Análisis de los tipos de señalización, la seguridad y cultura vial.
Manantial de vino : poemas de Li Tai Po
Authors: Dañino Guillermo
Published: July 2023

Li Tai Po o Li Po, en pronunciación regional y antigua, Li Tai Bai o Li Bai en la lengua china oficial contemporánea, putonghua, es para muchos el más importante de los poetas de la dinastía Tang y de toda la historia literaria de China. Símbolo, incluso, de la poesía misma. Su imagen de hombre libre, simpático, alegre, enérgico, amigable y espontáneo; su amor por la embriaguez, que sin pretensiones ofrece estados trascendentales de la mente; su fidelidad a los amigos de toda clase social; su admiración por la naturaleza y su devoción por la armonía universal, en el más puro estilo taoísta, son características tan personales que no sólo lo definen, sino que nos lo acercan como a un ser muy humano, desbordante de vida. A pesar de la lejanía cultural y temporal, su obra tiene la virtud de despertar en nosotros un renovador gozo estético por su belleza de formas y su temática. Admiramos, en virtud de la palabra bien dicha, una personalidad excepcional. Al leerlo se tiene la vivencia intensa de un poeta que pertenece al mundo. Sus versos nos acercan a un ser humano real, de fuerte temperamento, muy sensible y cordial. La energía que recorre sus líneas, concisas e imaginativas, transmite calor, sinceridad, entusiasmo, vida. Así se explica su difusión en ambientes disímiles por la cultura, el espacio o el tiempo. Teniendo en cuenta tan sólo las dimensiones chinas de su popularidad, se puede afirmar, sin duda alguna, que Li Bai ha sido y sigue siendo el poeta más leído de la historia del mundo.
Cyclic pulse loads pave the road to the GRIP concept in abdominal wall reconstruction
Authors: Lesch Carolin , Ludwig Yannique , Kugel Fabio , Uhr Katharina , Vollmer Matthias , Nessel Regine , Kallinowski Friedrich
Published: July 2023

Aim : Durable reconstruction of the abdominal wall needs to be assessed in a lifelike experimental setting and consider the reconstructed abdominal wall as a coherent compound. Our aim was to evaluate broader possibilities in preclinical testing and to deepen the understanding of the biomechanical influences.

Methods : We developed a test bench that allows studying a compound under cyclic, repetitive loads. Pulse loads transmit energy to the abdominal wall repeatedly. The amount of energy is related to the load characteristics. We used porcine bellies with a round central (5 cm) defect. They were bridged in a sublay position with Cicat Dynamesh®. Further defects, located in an additional incision, were sutured in a standardized small-bite technique. We varied the number of loads, the maximum peak pressure, the pressure plateau length, and the impact area size.

Results : Increasing the peak pressure by 30 mmHg lowers the durability by about 20 %. Prolonging the plateau phase led to a significant durability decrease. During the first 100 dynamic intermittent strain (DIS) impacts, the major tissue deformation and the majority of failures occur. Beyond the 425th DIS impact, about 10 % more failures occur. Increasing elongation and deformation of the tissue raise the likelihood of failure.

Conclusion : If the compound does not establish a strain-stable condition during the period of plastic deformation, failure occurs. The outcome does not only depend on the reconstruction technique but also on the external influences acting on the abdominal wall compound. Considering the biomechanical reality is important for open and minimally invasive abdominal wall reconstruction.
ESPAÇO COMERCIAL NA AVENIDA TOCANTINS EM TAQUARALTO CIDADE DE PALMAS
Authors: Simão José Francisco Rocha
Published: July 2023

O estudo discorre acerca da avenida Tocantins, uma das principais vias comerciais localizadas no setor Taquaralto na cidade de Palmas. O trabalho possui natureza metodológica de revisão de literatura e estudo de caso. O objetivo consiste em: descrever a Avenida Tocantins via espaço comercial. A pesquisa enfatiza características como, fluxo de pessoas, prestação de serviços e comércio. Observou-se no estudo, pouca infraestrutura para o acesso de pessoas com mobilidades físicas reduzidas à avenida, pouca sinalização de trânsito, como também, muitas lojas comerciais que se expandem do interior da loja para as caçadas, o que dificulta em muitos locais o fluxo das pessoas, além disso se notou, uma grande concentração de serviços e empreendimentos comerciais de vários seguimentos. Isso remete a reflexão e ações pontuais do poder público em parcerias com os comerciantes com o sentido de tornar a via mais confortável e com acessibilidade para todos.
SANTO DAIME
Authors: Sales Vanessa Maria Alves Lima , Silva Campêlo Fernanda Cristina da , Silva Marivaldo Cavalcante da
Published: July 2023

O Santo Daime é uma doutrina religiosa originária da região amazônica, fundada pelo denominado Mestre Irineu. É caracterizado pelo uso ritualístico da ayahuasca, um chá de propriedades psicoativas, e agrega elementos simbólicos de outras culturas religiosas/espiritualistas, como o xamanismo, catolicismo popular, umbandismo, kardecismo, entre outros. Tal doutrina encontra-se em expansão, tanto em solo brasileiro, para regiões urbanas, quanto para outros países. Diante desse contexto, o presente artigo teve como objetivo analisar o Santo Daime, correlacionando-o ao processo de hibridismo cultural e de multiterritorialidades. Foi percebida a relação existente entre a doutrina e o processo de hibridismo, tendo em vista que, além da hibridização inerente aos elementos simbólicos de outras matrizes religiosas, questões como a globalização, pós-modernidade tiveram influências no desenvolvimento e expansão do Santo Daime, assim como na formação de multiterritorialidades. Fomentou-se um trabalho de cunho interdisciplinar abarcando e dialogando elementos culturais e territoriais. Para tanto, foi realizado estudo bibliográfico composto de publicações e trabalhos científicos que versam sobre esta doutrina religiosa e de autores que trabalham com os conceitos acima citados.
Sixteen-year longitudinal evaluation of blood-based DNA methylation biomarkers for early prediction of Alzheimer’s disease
Authors: Hackenhaar Fernanda Schäfer , Josefsson Maria , Adolfsson Annelie Nordin , Landfors Mattias , Kauppi Karolina , Porter Tenielle , Milicic Lidija , Laws Simon M. , Hultdin Magnus , Adolfsson Rolf , Degerman Sofie , Pudas Sara
Published: July 2023

Background: DNA methylation (DNAm), an epigenetic mark reflecting both inherited and environmental influences, has shown promise for Alzheimer’s disease (AD) prediction.
Objective: Testing long-term predictive ability (>15 years) of existing DNAm-based epigenetic age acceleration (EAA) measures and identifying novel early blood-based DNAm AD-prediction biomarkers.
Methods: EAA measures calculated from Illumina EPIC data from blood were tested with linear mixed-effects models (LMMs) in a longitudinal case-control sample (50 late-onset AD cases; 51 matched controls) with prospective data up to 16 years before clinical onset, and post-onset follow-up. Novel DNAm biomarkers were generated with epigenome-wide LMMs, and Sparse Partial Least Squares Discriminant Analysis applied at pre- (10-16 years), and post-AD-onset time-points.
Results: EAA did not differentiate cases from controls during the follow-up time (p-values>0.05). Three new DNA biomarkers showed in-sample predictive ability on average 8 years pre-onset, after adjustment for age, sex, and white blood cell proportions (p-values: 0.022-< 0.00001). Our longitudinally-derived panel replicated nominally (p=0.012) in an external cohort (n=146 cases, 324 controls). However, its effect size and discriminatory accuracy were limited compared to APOEε4-carriership (OR=1.38 per 1 SD DNAm score increase vs. OR=13.58 for ε4-allele carriage; AUCs=77.2% vs. 87.0%). Literature review showed low overlap (n=4) across 3275 AD-associated CpGs from 8 published studies, and no overlap with our identified CpGs.
Conclusions: The limited predictive value of EAA for AD extends prior findings by considering a longer follow-up time, and with appropriate control for age, sex, APOE, and blood-cell proportions. Results also highlight challenges with replicating discriminatory or predictive CpGs across studies.
Differences in hyporheic water exchange in habitats of different aquatic Ranunculus species – case study in Poland
Authors: Marciniak Marek , Gebler Daniel , Grygoruk Mateusz , Zalewska-Gałosz Joanna , Szoszkiewicz Krzysztof
Published: July 2023

Hyporheic water exchange driven by groundwater-surface water interactions constitutes habitat conditions for aquatic biota. In our study we conducted field-research-based analysis of hyporheic water exchange to reveal whether the hyporheic water exchange differentiates particular Ranunculus sp. habitats. We measured the density of stream filtration and vertical gradients of water residing in the hyporheic zone. We revealed that R. peltatus and R. penicillatus persist in habitats of considerably higher hyporheic water exchange draining flux (respectively 0.0852 m3/d/m2 and 0.0952 m3/d/m2) than R. circinatus, R. fluitans and a hybrid of R. circinatus x R. fluitans (respectively 0.0568 m3/d/m2; 0.0222 m3/d/m2 and 0.0717 m3/d/m2). Presented results can be used as an indicator of aquatic habitats suitability in the case of protection and management of ecosystems settled by Ranunculus sp.
Protein arginine methyltransferase 5 (PRMT5) is an actionable therapeutic target in CDK4/6 inhibitor-resistant ER+/RB-deficient breast cancer
Authors: Lin Chang-Ching , Chang Tsung-Cheng , Wang Yunguan , Guo Lei , Gao Yunpeng , Bikorimana Emmanuel , Lemoff Andrew , Fang Yisheng , Zhang He , Zhang Yanfeng , Ye Dan , Soria-Bretones Isabel , Servetto Alberto , Lee Kyung-min , Luo Xuemei , Otto Joseph , Akamatsu Hiroaki , Napolitano Fabiana , Mani Ram , Cescon David , Xu Lin , Xie Yang , Mendell Joshua , Hanker Ariella , Arteaga Carlos
Published: July 2023

CDK4/6 inhibitors (CDK4/6i) have improved survival of patients with estrogen receptor-positive (ER+) breast cancer. However, patients treated with CDK4/6i eventually develop drug resistance and progress. RB1 loss-of-function alterations confer acquired resistance to CDK4/6i, but the optimal therapy for these patients is unclear. Using a genome-wide CRISPR screen, we identified protein arginine methyltransferase 5 (PRMT5) as a molecular vulnerability in ER+/RB1-knockout (RBKO) breast cancer cells. PRMT5 inhibition blocked cell cycle G1-to-S transition independent of RB, thus arresting growth of RBKO cells. Proteomics analysis uncovered fused in sarcoma (FUS) as a downstream effector of PRMT5. Pharmacological inhibition of PRMT5 resulted in dissociation of FUS from RNA polymerase II (Pol II), Ser2 Pol II hyperphosphorylation, and intron retention in genes that promote DNA synthesis. Treatment with the PRMT5i inhibitor pemrametostat and fulvestrant synergistically inhibited growth of ER+/RB-deficient patient-derived xenografts, suggesting dual ER and PRMT5 blockade as a novel therapeutic strategy to treat ER+/RB-deficient breast cancer.
Optimal selection of a sustainable alternative-fueled commercial vessel engine using multi-attribute decision-making
Authors: Kim Kyungrok
Published: July 2023

Various green seaborne transportation strategies, which minimize the impact of climate and economic losses on shipping, are used in the maritime industry. This study aimed to determine an optimal alternative fuel by measuring and evaluating four alternative marine fuels—liquefied natural gas (CH4), H2, NH3, and MeOH—in terms of sustainability using a multi-attribute decision-making methodology. These were ranked through life cycle sustainability assessments: environmental life cycle assessment, life cycle cost and net present value, and social life cycle assessment. The energy system model showed that in all assessments, the CH4-internal combustion engine (ICE) outperformed the other alternatives. The analysis also revealed that alternative fuel technologies were inferior when considering environmental, economic, and social multi-criteria evaluations. Because CH4 is technologically feasible, CH4-fueled ships have been commercialized and their infrastructure for extraction, storage, delivery, and use have become well-established along major routes. However, CH4 is a fossil fuel, and events such as oil shocks can recur because of regulations in countries with sizable natural gas reserves. Therefore, the technological development of H2-ICE, H2-solid oxide fuel cell (SOFC), and MeOH-SOFC, which are the most suitable technologies together with CH4, is essential.
Repression of ferroptotic cell death by mitochondrial calcium signaling
Authors: Wen Haitao , Chen Jianwen , Zhao Bao , Wang Shen , Ma Anjun , Dong Hong , Cheng Xiang , Lin Shengyin , Li Xinghui , Herring Laura , Xin Gang , Ma Qin , He Kai , Xie Ruili , Lei Yu , ingold Irina , Cheng Xiaolin , Li Zihai
Published: July 2023

The uptake of Ca2+ into and extrusion of calcium from the mitochondrial matrix, regulated by the mitochondrial Ca2+ uniporter (MCU), is a fundamental biological process that has crucial impacts on cellular metabolism, signaling, growth and survival. Herein, we report that the embryonic lethality of Mcu-deficient mice is fully rescued by orally supplementing ferroptosis inhibitor lipophilic antioxidant vitamin E and ubiquinol. Mechanistically, we found MCU promotes acetyl-CoA-mediated GPX4 acetylation at K90 residue, and K90R mutation impaired the GPX4 enzymatic activity, a step that is crucial for ferroptosis. Structural analysis supports the possibility that GPX4 K90R mutation alters the conformational state of the molecule, resulting in disruption of a salt bridge formation with D23, which was confirmed by mutagenesis studies. Finally, we report that deletion of MCU in cancer cells caused a marked reduction in tumor growth in multiple cancer models. In summary, our study provides a first direct link between mitochondrial calcium level and sustained GPX4 enzymatic activity to regulate ferroptosis, which consequently protects cancer cells from ferroptosis.
Leveraging Marine Predators Algorithm with Deep Learning Object Detection for Accurate and Efficient Detection of Pedestrians
Authors: Gogineni Hima Bindu , Bhuyan Hemanta Kumar , Lydia Laxmi
Published: July 2023

Pedestrian detection using object detection and deep learning has been found to be effective method for identifying pedestrians in video frames or images accurately. It is more commonly used in many real-time applications, such as security observing systems, autonomous driving systems, and robotics. The combination of deep learning techniques and object detection algorithms allows efficient and robust detection of pedestrians in several real-time scenarios. But it is necessary to improve the detection efficacy for complex environments such as cases with worse visibility due to weather or daytime, crowd scenes, and rare pose samples. Continuous improvement and research in DL algorithms, dataset collection, and training models contribute to accelerating the robustness and accuracy of pedestrian detection systems. Therefore, this study designs a new marine predator algorithm with deep learning-based pedestrian detection and classification (MPADLB-PDC) technique. The objective of the MPADLB-PDC approach lies in the accurate recognition and classification of pedestrians. To achieve this, the MPADLB-PDC technique involves two major processes, namely object detection and classification. In the first stage, the MPADLBPDC technique uses an improved YOLOv7 object detector for the recognition of the objects in the frame. Next, in the second stage, the ensemble classifier comprises three classifiers such as deep feed-forward neural network (DFFNN), extreme learning machine (ELM), and long short-term memory (LSTM). To improve the recognition performance of the ensemble classifier, the MPA is used to optimally select the parameters related to it. The simulation outcome of the MPADLB-PDC system was validated on the pedestrian database, and the outcome can be studied interms of various aspects. The simulation values validated the better outcome of the MPADLB-PDC system compared to other approaches.
Effect of probiotics on honeymoon period duration and glycemic control of type one diabetes mellitus: A randomized controlled double blind clinical trial study protocol
Authors: moazzen nasrin , ghaemi nosrat , ahanchian hamid , nikpour sara , Bagheri Sepideh
Published: July 2023

Background
type 1 diabetes is one of the most chronic diseases of childhood. The therapeutic recommendation for this condition is quite complex and needs changes in lifestyle. Recently the role of gut microbiota has received attention as a possible mechanism in the pathogenesis and control of the disease.
Methods
One hundred thirty Children aged 6–18 years old with newly diagnosed diabetes type one participate in the trial they are randomly assigned to the intervention or control group. The patients will receive a six month course of probiotics or placebo besides their conventional treatment with insulin. And they will be followed for at least one year. Participants are followed at 3 month intervals for one year. At each visit anthropometrical data, glycemic control and total dose of insulin required to keep the optimal glycemic control is evaluated and registered.
Discussion
There is evidence that alterations in gut microbiota is seen in children with diabetes. In this study we aim to evaluate the effect of probiotic administration on the duration of honeymoon period in pediatrics with type one diabetes and their glycemic control and insulin requirements.
Clinical trial registration: IRCT20200117046164N3
System analysis based on the necroptosis-related genes in heart failure
Authors: Kong Yiya , Guo Ying , Xu Tao , Zhou Jihong , Wang Fang
Published: July 2023

Background: Heart failure(HF) is an emerging epidemic clinical syndrome that remains a leading cause of global morbidity and mortality. This study aimed to determine necroptosis' role in HF using bioinformatics analyses.
Methods: A total of 3 datasets, including myocardial tissues samples from 225 HF patients and 26 normal people, were acquired from the Gene Expression Omnibus (GEO). Necroptosis-related differentially expressed genes (NRDEGs) in HF were determined. A prediction model based on three NRDEGs were constructed to assess the risk of HF. Then, consensus clustering, protein-protein interactions (PPI), and identifying the top 10 hub genes were performed. The Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), and Gene Set Enrichment Analysis (GSEA) were carried out. Investigations were conducted into immune infiltration. Furthermore, the eight NRDEGs’ mRNA expression level was validated in blood samples by quantitative real time-PCR (RT-qPCR).
Results:
A total of eight NRDEGs, namely FLOT1, DAPK1, KLHDC10, FLOT2, FAS, UCHL1, TNFAIP3, HSPA5, were excavated and further verified by RT-qPCR in blood samples. The expression levels of TNFAIP3 and HSPA5 were lower in HF, consistent with bioinformatics analysis. The correlation analysis revealed the regulatory network between 51 NRGs. The HF risk prediction model constructed of FLOT2, FAS and FLOT1 has relatively good accuracy and reliability. The 10-hub-genes associated with necroptosis might be significantly related to HF. Among10-hub-genes, STIP1, TGFBR2, and HSPD1 might be potential markers to indicate the early stage or progression of HF. The GSEA clarified nine relevant enrichment pathways.
Conclusion: Our research supplies new information and views for investigating the underlying necroptosis-related mechanism and possible treatments of HF.
A solution method for nonlinear monotone equations via hybrid spectral conjugate gradient and signal recovery problems
Authors: Yusuf Aliyu , Manjak Nibron Haggai , Mohammad Hassan , Kiri Aliyu Ibrahim , Abubakar Auwal Bala
Published: July 2023

In this paper, we propose a solution method via hybrid spectral conjugate gradient and signal recovery problem (ANHSCG) to solve nonlinear monotone equations. This has been done using the hybrid conjugate gradient (CG) parameters of Dai-Yuan (DY), conjugate descent (CD), Hestenes-Stiefel (HS), Liu-Storey (LS) and the corresponding search direction of spectral conjugate gradient method. The search direction has proved to be adequately descent regardless of the step-size. Under reasonable assumptions, the convergence of the algorithm is established. Additionally, numerical tests are run on a set of benchmark test problems to illustrate the effectiveness and competitiveness of the new algorithm compared with other existing alternatives. Finally, some applications of the proposed algorithm is explored.
Mathematics Subject Classification: 65K05, 90C52, 90C26
UV-B induced HSV-1 reactivation leads to infectious virus in the corneas of virtually all latently infected mice and requires an intact STING to develop herpetic stromal keratitis
Authors: Yin Xiao-Tang , Hartman Alexis , Sirajuddin Nadia , Shukla Deepak , Leger Anthony St. , Keadle Tammie L. , Stuart Patrick M.
Published: July 2023

Reactivation of latent herpes simplex type 1 results in virus returning to the cornea leading to recurrent herpetic stromal keratitis (rHSK). We compare two competing models to reactivate viruses from latency, UV-B irradiation and cyclophosphamide. Results revealed that while both result in corneal recrudescence, only UV-B irradiation results in rHSK. To better understand the dynamics of reactivation, we analyzed corneas for both the presence of infectious viruses and the dynamics of exposure to multiple reactivations using UV-B. We noted that multiple reactivations result in progressively worse corneal disease. We also noted that expression of IFNα and STING, surragate markers for the presence of virus, are induced by the presence of reactivated virus. Studies to determine the importance of STING to the development of HSK revealed that in the absence of STING, mice do not develop significant HSK and the magnitude of the infiltrate of CD45 + cells in these corneas is significantly reduced. The resulting paucity of CD45 + CD11b + GR-1 + F4/80-neutrophils, and to a lesser extent CD45 + CD11b + GR-1-F4/80 + macrophages in B6-STING KO mice following reactivation is likely the underlying cause for lack of rHSK as has been noted by ourselves and others. These results underscore the critical importance of STING’s role in developing rHSK.
Application and evaluation of classic and demand oriented cooling strategies in context of machine tools
Authors: Wenkler Eric , Steiert Christoph , Ihlenfeldt Steffen , Weber Jürgen
Published: July 2023

Energy consumption is an important factor in the operation of machine tools
Recent studies showed that in average 1/5 of the machine tools total energy demand is caused by internal cooling systems.
The continually rising performance of machine tools together with the importance of thermal stability, reasons the requirement for demand oriented cooling approaches, which could significantly reduce the energy consumption for internal machine cooling.
This study applied classic and demand oriented cooling strategies on a machine tool frame, which is one of the most complex machine tool components from a thermal point of view.
The demand oriented cooling is based on volume flow control and can either be configured close to the environmental temperature or close to the thermal steady state, which can be obtained by loss forecast in combination with an FE-Model or measurement.
The impact of the strategies on the thermal reaction as well as the energy consumption is compared, showing a significant reduction of energy demand without significant impairment of the thermal stability.
Economic and clinical burden in patients with primary hyperoxaluria treated with dialysis: A real- world evidence study in the United States
Authors: Fazio-Eynullayeva Elnara , Karafilidis John , Chen Herman , Brown Jeffrey S.
Published: July 2023

Background: Primary hyperoxaluria (PH) is a family of rare genetic disorders characterized by dysregulation of glyoxylate metabolism. PH is associated with nephrocalcinosis and chronic kidney disease, which often requires dialysis treatment and organ transplant as the disease progresses to end-stage kidney disease. Limited patient data resulting from low incidence rates and diagnostic challenges associated with PH have prevented adequate characterization of the economic and clinical burden of the disorder. This study examined demographic characteristics, clinical markers, and healthcare utilization of dialysis-treated patients with PH.
Methods: This real-world retrospective study analyzed data from the TriNetX Dataworks USA Network from October 1, 2018, to February 2, 2021. The study cohort comprised of patients with a PH diagnosis who initiated dialysis during the study period. Demographics, clinical markers, and healthcare utilization were captured during the baseline period before initiating the first dialysis and during follow-up. Clinical disease progression was assessed via eGFR measurements and the number of kidney stone events (KSE).
Results: A total of 47 patients with PH were eligible for this analysis, of whom just 46.8% received a clinical diagnosis of PH before initiating dialysis. The mean age of the cohort was 58.7 years, and the majority of patients were female (53.2%), White (85.1%), and non-Hispanic/Latino (78.7%). The mean value of the earliest eGFR measurement was 27.2 mL/min, and 42.6% of patients had documented acute renal insufficiency during the baseline period. KSEs were highest in the baseline period immediately preceding dialysis initiation. Healthcare costs within the 12 months preceding and the 12 months following dialysis initiation were a mean of $150,346 and $217,784, respectively.
Conclusions: A delayed diagnosis was common among patients with PH, with over half of the cohort receiving their diagnosis after commencing dialysis. Patients with PH are burdened with high healthcare costs and complicated care pathways up to and following the first instance of dialysis. Future research focusing on strategies to improve health outcomes and address the financial burden associated with PH is warranted.
Replicability and reproducibility of predictive models for diagnosis of depression among young adults using Electronic Health Records
Authors: Nickson David , Singmann Henrik , Meyer Caroline , Toro Carla , Walasek Lukasz
Published: July 2023

Background
Recent advances in machine learning combined with the growing availability of digitized health records offer new opportunities for improving early diagnosis of depression. An emerging body of research shows that Electronic Health Records can be used to accurately predict cases of depression on the basis of individual’s primary care records. The successes of these studies are undeniable, but there is a growing concern that their results may not be replicable, which could cast doubt on their clinical usefulness.
Methods
To address this issue in the present paper, we set out to reproduce and replicate the work by Nichols et al. (2018), who trained predictive models of depression among young adults using Electronic Healthcare Records. Our contribution consists of three parts. First, we attempt to replicate the methodology used by the original authors, acquiring the same set of primary health records and reproducing their data processing and analysis. Second, we test models presented in the original paper on our own data, thus providing out of sample prediction of the predictive models. Third, we extend past work by considering several novel machine learning approaches in an attempt to improve the predictive accuracy achieved in the original work.
Results
In summary, our results demonstrate that the work of Nichols et al. is largely reproducible and replicable. This was the case both for the replication of the original model and the out of sample replication applying NRCBM coefficients to our new EHRs data. Although alternative predictive models did not improve model performance over standard logistic regression, our results indicate that stepwise variable selection is not stable even in the case of large data sets.
Conclusion
We discuss the challenges associated with the research on mental health and Electronic Health Records, including the need to produce interpretable and robust models. We demonstrated some potential issues associated with the reliance on EHRs, including changes in the regulations and guidelines (such as the QOF guidelines in the UK) and reliance on visits to GP as a predictor of specific disorders.
Analysis of bacterial spectrum and drug sensitivity in preoperative urine culture of upper urinary calculi
Authors: zhao changyuan
Published: July 2023

OBJECTIVE:
To analyze the distribution of urinary culture pathogenic bacteria and drug resistance in patients with upper urinary calculi combined with urinary tract infections.
METHODS:
Seventy-three patients with upper urinary calculi combined with urinary tract infection who were hospitalized in Taikang Xianlin Drum Tower Hospital from January 2020 to April 2023 were retrospectively analyzed as study subjects. The patients' midstream urine samples was collected in morning, and urine culture and drug sensitivity tests were performed to analyze their pathogenic bacteria distribution and drug resistance.
Results:
In the urine specimens of 73 patients with upper urinary calculi, 80 pathogenic bacteria were detected, including 52 were Gram-negative bacteria (65.00%), 23 were Gram-positive bacteria (28.75%) and 5 were fungi (6.25%). Gram-negative bacteria were mainly Escherichia coli, Gram-positive bacteria were mainly Enterococcus faecalis, and fungi were mainly candida albicans; the top 10 drugs in terms of sensitivity to Gram-negative bacteria were imipenem(100.00%), cefoperazone/sulbactam(100.00%), meropenem (100.00%), amikacin(98.04%), piperacillin/tazobactam (96.08%), cefotetan(93.62%), Nitrofurantoin(84.85%), cefepime(84.44%), aztreonam(81.63%), and tobramycin(76.92%). The top three drug resistance rates were ampicillin(84.62%), piperacillin(56.86%), and ampicillin/sulbactam(46.15%). The drugs with high sensitivity rates to gram-positive bacteria were vancomycin(100%), linezolid(100%), tigecycline(100%), Nitrofurantoin (94%), ampicillin(83%), and penicillin G(79%).
CONCLUSION:
Gram-negative and Gram-positive bacteria are the main pathogens of urinary tract infections in patients with upper urinary calculi, and their major strains differ in their resistance to commonly used antimicrobial drugs.
Influence of Non-Homogeneity, Rotation, Magnetic Field, and Initial Stress on Radial Vibrations in Thermo-Viscoelastic Isotropic Media
Authors: Balubaid Mohammed A.
Published: July 2023

This paper presents an innovative analytical approach to investigate the effects of rotation and initial stress on a magneto-thermo-viscoelastic non-homogeneous medium with a spherical cavity under periodic loading. The study focuses on analyzing the distribution of displacements, temperature, and stresses within the non-homogeneous medium using the generalized thermoelasticity framework based on the GL theory. The derived analytical solutions are extensively discussed, and the results are visually presented to illustrate the influences of rotation, initial stress, relaxation times, magnetic field, viscoelasticity, and non-homogeneity. Furthermore, comprehensive comparisons with prior research are conducted, encompassing scenarios with and without rotation, magnetic field, and initial stress. These comparisons contribute to establishing the significance of the findings and highlight the advancements made in this study in relation to existing knowledge in the field.
MSC: 74F15, 74H45, 74J20, 74K10
Association between mammillary body atrophy and memory impairment in retired athletes with a history of repetitive mild traumatic brain injury
Authors: Miyata Mari , Takahata Keisuke , Sano Yasunori , Yamamoto Yasuharu , Kurose Shin , Kubota Manabu , Endo Hironobu , Matsuoka Kiwamu , Tagai Kenji , Oya Masaki , Hirata Kosei , Saito Fumie , Mimura Masaru , Kamagata Koji , Aoki Shigeki , Higuchi Makoto
Published: July 2023

Cognitive dysfunction, especially memory impairment, is a typical clinical feature of long-term symptoms caused by repetitive mild traumatic brain injury (rmTBI). The current study aims to investigate the relationship between regional brain atrophy and cognitive impairments in retired athletes with a long history of rmTBI. Overall, 27 retired athletes with a history of rmTBI (18 boxers, 3 kickboxers, 2 wrestlers, and 4 others; rmTBI group) and 23 age/sex-matched healthy participants (control group) were enrolled. MPRAGE on 3T MRI was acquired and segmented. The total brain volume (TBV) and regional brain volumes of the mammillary bodies (MBs), hippocampi, amygdalae, thalami, caudate nuclei, and corpus callosum (CC) were estimated using the SPM12 and ITK–SNAP tools. The rmTBI group underwent neuropsychological tests for verbal and visual memory, attention, executive function, and global cognitive function. TBV and TBV-adjusted regional brain volumes were compared between rmTBI and control participants using the Mann-Whitney U test. Furthermore, we assessed the relationship of the memory test to TBV and TBV-adjusted regional brain volumes by the Spearman’s rank correlation coefficient. The TBV and TBV–adjusted regional brain volumes were compared between groups, and the relationship between the neuropsychological test scores and the regional brain volumes were evaluated. Compared with the control group, the rmTBI group showed significantly lower MBs volume/TBV ratio (0.13 ± 0.05 vs. 0.19 ± 0.03 ×10− 3, p < 0.05) and The CC volume/TBV ratio (12.5 ± 1.63 vs. 13.6 ± 1.81 ×10− 3, p < 0.05). The MBs volume/TBV ratio correlated with visual and verbal memory, as assessed, respectively, by the Rey–Osterrieth Complex Figure test delayed recall (ρ = 0.48, p < 0.05) and logical memory delayed recall (ρ = 0.41, p < 0.05). The CC volume/TBV ratio didn’t correlate with any cognitive assessment result (p > 0.05). MB disconnection from the Papez circuit is associated with memory impairment in retired athletes with rmTBI.
Preliminary evaluation of the clinical efficacy of salmon calcitonin nasal spray in patients with rotator cuff tears after arthroscopic repair: a retrospective study
Authors: Lyu Fei , Du Jianwei , Li Jianan , Wu Yafei , Xu Zheng , Shi Dai
Published: July 2023

Background Rotator cuff tears (RCTs) are the most common shoulder disorder, which can be effectively treated by arthroscopic technique. However, the re-tear rates following rotator cuff repair range from 10% in small tears to 91% in massive tears, leading to a failure of healing, particularly in patients with osteoporosis or acute bone loss. Calcitonin used for acute bone loss has currently become a consensus. This study aims to assess the efficacy of salmon calcitonin nasal spray (SCNS) in patients with RCTs after arthroscopic repair.
Methods It was a retrospective study which involved patients affected by RCTs from January 2018 to December 2019. All of the patients accepted arthroscopic surgery and were divided into two groups, with or without use of SCNS after the surgery. Patients were evaluated with clinical examination, pain scores based on visual analog scale (VAS) and functional outcomes based on the Constant-Murley shoulder score (CMS) and simple shoulder test (SST) before surgery, at 3, 6, and 24 months after surgery.
Results Groups 1 (control group) and 2 (study group) comprised 26 and 29 patients, respectively, who showed no significant differences in demographic characteristics (p>0.05). In general, the mean ± sd of patient age was 52.27 ± 8.53 years (range, 39–75 years). Among the patients, 28 (50.9%) were male, and 27 (49.1%) were female. Shoulder function (CMS, SST) improved over time in both groups (p<0.05). At 3 months, VAS, CMS and SST values in study group were superior to those in control group (p<0.05). However, this trend was not persisted at 6 and 24 months. Tendon re-tear was seen in two of the patients in control group, but there was no significant difference in re-tear rates in the two groups (p=0.219). No other post-surgical complication was found in either group.
Conclusions Use of SCNS could significantly reduce postoperative pain level and improve shoulder function in the early stage after arthroscopic repair, but it could not decrease the rotator cuff re-tear rate. Prospective studies involving large samples are required to observe the long term effects further more.
Bilateral inguinal hernia repair by laparoscopic totally extraperitoneal (TEP) vs. laparoscopic transabdominal preperitoneal (TAPP)
Authors: Hidalgo Nils Jimmy , Guillaumes Salvador , Bachero Irene , Butori Eugenia , Espert Juan José , Ginestà César , Vidal Óscar , Momblán Dulce
Published: July 2023

Background: The guidelines recommend laparoscopic repair for bilateral inguinal hernia. However, few studies compare the totally extraperitoneal (TEP) and transabdominal preperitoneal (TAPP) techniques in bilateral inguinal hernia. This study aimed to compare the outcomes of TEP and TAPP in bilateral inguinal hernia.
Methods: We conducted a retrospective cohort study of patients operated on for bilateral inguinal hernia by TEP and TAPP repair from 2016 to 2020. Intraoperative complications, operative time, acute postoperative pain, hospital stay, postoperative complications, chronic inguinal pain, and recurrence were compared.
Results: A total of 155 patients were included in the study. TEP was performed in 71 patients (46%) and TAPP in 84 patients (54%). The mean operative time was longer in the TAPP group than in the TEP group (107 min vs. 82 min, p<0.001). The conversion rate to open surgery was higher in the TEP group than in the TAPP group (8.5% vs. 0%, p=0.008). The mean hospital stay was longer in the TAPP group than in the TEP group (p<0.001). We did not observe significant differences in the proportion of postoperative complications(p=0.672), postoperative pain at 24 hours (p=0.851), chronic groin pain (p=0.593), and recurrence (p=0.471). We did not observe an association between the choice of surgical technique (TEP vs. TAPP) with postoperative complications, chronic inguinal pain, or hernia recurrence; when performing a multivariable analysis adjusted for the male sex, age ≥65 years, BMI ≥30, ASA II-IV, recurrent hernia repair, and hernia size >3cm.
Conclusions: We did not find significant differences in postoperative complications, acute postoperative pain, chronic inguinal pain, and recurrence. Operative time and hospital stay were longer in TAPP, while TEP conversion to open surgery was higher.
Study on Wild Edible Plant Used by Shinasha Ethnic Community at Metekel Zone, Northwest Ethiopia
Authors: Birhanu Abesh
Published: July 2023

Wild edible plants are an essential source of supplementary foods in many parts of Ethiopia. The aims of this study were to record and document wild edible plants used by shinasha ethnic community in Metekele Zone Northwestern Ethiopia. The Field surveys were conducted from Jun to Dec, 2022. Semi-structured interview, direct observation, focus group discussion, guided fled walks, and market surveys were used to collect data. A total of 120 informants were participated in interviewed. Descriptive statistical was made to analyze the data using SPSS version.20. A total 46 wild edible plants belonging to 38 genera and 30 families were recorded. Family Moraceae were the most popular edible plant. Trees were the dominant life forms (36.9%) and ripe fruits (58.6%) recorded plants par used in study area. The majority of (14 specie) were collected from natural forest followed by riverine banks habitat (12species). The majority of wild edible plants are mainly harvested and consumed during autumn followed by summer season. Based on the market surveys eight wild edible plants were sold and can provide additional income to the local community in study districts. The wild edible plants were consumed as raw. Agricultural land expansion, fuel wood collection, cutting for construction, uncontrolled fire and overgrazing were the major threats to the wild edible plants. Hence, the finding recommend that the community that practice in on-site and off-site conservation, public awareness raising, which requires participation the government's on sustainable forest management practices approach would help to protect wild edible plant in study area.