bluuebunny/crossref_metadata_2025 huggingface dataset:
The Role of Industrial Structure Upgrading in Moderating the Impact of Environmental Regulation on Air Pollution: Evidence from China
Authors: Liu Yu , Xie Chun-Ni , Wang Zi-Shuang , Rebai Noure-El Houda , Lai Xiao-Min
Published: October 2023

Air pollution is an important factor affecting human health and daily life. The Chinese government is making vigorous efforts to control air pollution. The upgrading of the industrial structure is a problem-solving tool in the environment and economic growth cases. This paper aims to explore the relationships among environmental regulation, the upgrading of the industrial structure and air pollution. The PVAR (Panel Vector Auto Regression) model and moderating effect model are used to conduct empirical analysis based on panel data of 30 provinces in China from 2004 to 2020. The analysis of the results provides the following findings. Firstly, environmental regulations can significantly reduce emissions, but the deterioration of air quality does not have a significant impact on the improvement of environmental regulations. Secondly, industrial structure upgrading can reduce air pollution, but the worsening of the air quality will hinder the upgrading of industrial structures. Thirdly, environmental regulation can promote industrial structure upgrading. Lastly, industrial structure upgrading is a moderating variable and can positively moderate the impact of environmental regulations on air pollution.
Advances in Oxidative Coupling of Methane
Authors: Deng Jinlin , Chen Peili , Xia Shengpeng , Zheng Min , Song Da , Lin Yan , Liu Anqi , Wang Xiaobo , Zhao Kun , Zheng Anqing
Published: October 2023

C2+ hydrocarbons, especially C2+ olefins, as important basic chemical raw materials, mainly come from petroleum cracking. With the increasing scarcity of petroleum resources, the search for new olefins production routes has become the focus of research, and the production of olefins by the oxidative coupling of methane (OCM) process has attracted extensive attention. The OCM route is an important alternative to the production of olefins from petroleum resources and is also an important direction for the development of efficient and clean utilization of natural gas. In this paper, the mechanism, catalysts, and other key factors for the production of olefins by methane oxidative coupling are reviewed. The mechanism of OCM, including the reaction pathway and the formation of intermediate products, is introduced. Then, commonly used catalysts, such as alkali metal/alkaline earth metal oxides, rare earth metal oxides, composite metal oxides with special structures, and classical catalysts Mn/Na2WO4/SiO2, and their mechanisms of action in the reaction are discussed. In addition, the application of chemical looping oxidative coupling of methane (CLOCM) in olefin production is also investigated, which is a promising alternative way due to the high selectivity of olefins and the low cost of catalysts owing to the excellent performance of the catalyst recycling. These studies will help to further understand the mechanism of OCM for olefin production and provide guidance and support for applications in related fields.
Analysis of the Causes and Wind Field Structure of a Dry Microburst in a Weak Weather Background
Authors: Feng Liang , Zheng Jiafeng , Pan Jia , Bai Hanbing , Zhang Jun
Published: October 2023

Dry microbursts in weak weather backgrounds, due to their small scale and general lack of precipitation, are often difficult to observe using weather radar. On the night of 26 April 2023, a dry microburst occurred at the Yinchuan Airport. Based on conventional meteorological observations, Automated Weather Observing System (AWOS) data, and the Doppler Wind Lidar data, an analysis was conducted on the causes and wind field structure of this microburst. It was found that (1) the sounding data indicated a DCAPE value of 880 J·kg−1, which is important for forecasting the potential for dry microburst events; (2) the foehn from the Helan Mountains contributed to the occurrence of microburst weather at the Yinchuan Airport; (3) the Doppler Wind Lidar wind data showed distinct characteristics of the wind field during this microburst event, including a symmetric horizontal wind field structure, significant vertical downdraft velocities (reaching −5.76 m·s−1), and low-level wind shear over the airport runway and its vicinity; and (4) effective monitoring of such microburst weather events with the Doppler Wind Lidar wind measurements is crucial for ensuring aviation safety.
Background Characteristics and Influence Analysis of Greenhouse Gases at Jinsha Atmospheric Background Station in China
Authors: Wu Dongqiao , Yue Yanyu , Jing Junshan , Liang Miao , Sun Wanqi , Han Ge , Lou Mengyu
Published: October 2023

Central China has been acting as a major convergence zone for sources and sinks in China, such that the climate change studies of Central China have taken on critical significance. The Jinsha atmospheric background station refers to the sole background monitoring site in Central China. It is noteworthy that the greenhouse gas attributes of the Jinsha atmospheric background station represent the greenhouse gas conditions of Central China. The seasonal and daily variations in CO2, CH4, and CO in the scope of time between October 2019 to April 2021 at the station were examined in this study. The effect of meteorological conditions on greenhouse gas concentrations at the site was evaluated. Furthermore, the primary transmission origins affecting the station were identified using the backward trajectory through potential source contribution function analysis. As indicated by the results, the background concentrations at the Jinsha station in 2020 for CO2, CH4, and CO reached 424.1 ± 0.1 ppm, 2046.2 ± 0.6 ppb, and 324.1 ± 1.1 ppb, respectively. CO2 varied on a daily basis with higher nighttime levels, which was affected by the boundary layer elevation, photosynthesis, and human activities. In autumn, CH4 levels peaked under the effect of agricultural activities in Central China. However, CO2 and CO concentrations reached the maximum in winter, majorly affected by the transmissions from the Beijing–Tianjin–Hebei region and Hubei. Under China’s comprehensive carbon neutrality, more attention should be paid to the emissions from winter heating and industrial activities in the Beijing–Tianjin–Hebei region, and effects exerted by transport in the monitoring process should be differentiated in depth.
Validation and Spatiotemporal Analysis of Surface Net Radiation from CRA/Land and ERA5-Land over the Tibetan Plateau
Authors: Gao Limimg , Zhang Yaonan , Zhang Lele
Published: October 2023

High spatial–temporal resolution surface net radiation (RN) data are of great significance to the study of climate, ecology, hydrology and cryosphere changes on the Tibetan Plateau (TP), but the verification of the surface net radiation products on the plateau is not sufficient. In this study, the China Meteorological Administration Global Land Surface Reanalysis Products (CRA/Land) and ECMWF Land Surface Reanalysis version 5 (ERA5-Land) RN data were validated using ground measurements at daily and monthly time scales, and the spatiotemporal patterns were also analyzed. The results indicate the following: (1) CRA/Land overestimated while ERA5-Land underestimated RN, but CRA/Land RN outperformed ERA5-Land in observations at the daily and monthly scale. (2) The CRA/Land RN data had a larger error in the central part and a smaller error in the northeast of the TP, while ERA5-Land showed the opposite. (3) The spatial patterns of RN revealed by CRA/Land and ERA5-Land data showed differences in most regions. The CRA/Land data showed that the RN of the TP had a downward trend during 2000 and 2020 with a slope of −0.112 W·m−2/a, while the ERA5-Land data indicated an upward trend with a change rate of 0.016 W·m−2/a. (4) Downwelling shortwave radiation (DSR), upwelling shortwave radiation (USR), downwelling longwave radiation (DLR) and upwelling longwave radiation (ULR) are the four components of RN, and the evaluation results indicate that the DSR, DLR and ULR recorded via CRA/Land and ERA5-Land are consistent with the observed data, but the consistency between the USR recorded via CRA/Land and ERA5-Land and the observed data is poor. (5) The inconsistency of the USR data is the main reason for the large differences in the spatiotemporal distribution of CRA/Land and ERA5-Land RN data across the TP.
Encapsulation of Amyloglucosidase in Chitosan-SDS Coacervates as a Means to Control Starch Hydrolysis in Plant-Based Beverages
Authors: Chalella Mazzocato Marcella , Jacquier Jean-Christophe
Published: October 2023

Starch enzymatic hydrolysis is a key technology for preparing plant-based dairy alternative beverages, preferred for its low energy consumption, high product yield, and quality. However, the high-temperature requirement to terminate reactions and challenges in continuous operations hinder enzyme applicability. Therefore, encapsulation techniques have been explored to address these limitations, enhancing the enzyme’s stability and facilitating process control. This study developed a novel amyloglucosidase encapsulation system based on chitosan-SDS hydrogel capsules produced by simple coacervation. The enzymatic activity of free and immobilised amyloglucosidase was assessed using corn starch and maltose as substrates. The encapsulation process successfully yielded self-supporting structured and spherical capsules, achieving an immobilisation yield of 71% and an enzyme efficiency of 83%. The residual enzymatic activity after 28 days of storage remained at 76%. A feedback inhibition investigation was performed by varying the concentration of corn starch, and favourable applicability of encapsulated amyloglucosidase for continuous processes was found. The encapsulation process offered several advantages, such as a straightforward separation step to halt enzymatic reactions and no need for high temperatures that may affect food product attributes. Lastly, the amyloglucosidase-chitosan-SDS coacervates show promise in improving enzyme stability, facilitating hydrolysis control, and expanding enzyme utilisation in dairy alternative plant beverage manufacture.
Enhancement of Hip X-ray with Convolutional Autoencoder for Increasing Prediction Accuracy of Bone Mineral Density
Authors: Nguyen Thong Phi , Chae Dong-Sik , Choi Sung Hoon , Jeong Kyucheol , Yoon Jonghun
Published: October 2023

It is very important to keep track of decreases in the bone mineral density (BMD) of elderly people since it can be correlated with the risk of incidence of major osteoporotic fractures leading to fatal injuries. Even though dual-energy X-ray absorptiometry (DXA) is the one of the most precise measuring techniques used to quantify BMD, most patients have restricted access to this machine due to high cost of DXA equipment, which is also rarely distributed to local clinics. Meanwhile, the conventional X-rays, which are commonly used for visualizing conditions and injuries due to their low cost, combine the absorption of both soft and bone tissues, consequently limiting its ability to measure BMD. Therefore, we have proposed a specialized automated smart system to quantitatively predict BMD based on a conventional X-ray image only by reducing the soft tissue effect supported by the implementation of a convolutional autoencoder, which is trained using proposed synthesized data to generate grayscale values of bone tissue alone. From the enhanced image, multiple features are calculated from the hip X-ray to predict the BMD values. The performance of the proposed method has been validated through comparison with the DXA value, which shows high consistency with correlation coefficient of 0.81 and mean absolute error of 0.069 g/cm2.
Individualized PEEP without Recruitment Maneuvers Improves Intraoperative Oxygenation: A Randomized Controlled Study
Authors: Pan Lili , Yang Li , Gao Lingling , Zhao Zhanqi , Zhang Jun
Published: October 2023

Individualized positive end-expiratory pressure (PEEP) combined with recruitment maneuvers improves intraoperative oxygenation in individuals undergoing robot-assisted prostatectomy. However, whether electrical impedance tomography (EIT)-guided individualized PEEP without recruitment maneuvers can also improve intraoperative oxygenation is unknown. To test this, fifty-six male patients undergoing elective robot-assisted laparoscopic prostatectomy were randomly assigned to either individualized PEEP (Group PEEPIND, n = 28) or a control with a fixed PEEP of 5 cm H2O (Group PEEP5, n = 28). Individualized PEEP was guided by EIT after placing the patients in the Trendelenburg position and performing intraperitoneal insufflation. Patients in Group PEEPIND maintained individualized PEEP without intermittent recruitment maneuvers, and those in Group PEEP5 maintained a PEEP of 5 cm H2O intraoperatively. Both groups were extubated in a semi-sitting position once the extubation criteria were met. The primary outcome was arterial oxygen partial pressure (PaO2)/inspiratory oxygen fraction (FiO2) prior to extubation. Other outcomes included intraoperative driving pressure, plateau pressure and dynamic, respiratory system compliance, and the incidence of postoperative hypoxemia in the post-operative care unit (PACU). Our results showed that the intraoperative median for PEEPIND was 16 cm H2O (ranging from 12 to 18 cm H2O). EIT-guided PEEPIND was associated with higher PaO2/FiO2 before extubation compared to PEEP5 (71.6 ± 10.7 vs. 56.8 ± 14.1 kPa, p = 0.003). Improved oxygenation extended into the PACU with a lower incidence of postoperative hypoxemia (3.8% vs. 26.9%, p = 0.021). Additionally, PEEPIND was associated with lower driving pressures (12.0 ± 3.0 vs. 15.0 ± 4.4 cm H2O, p = 0.044) and better compliance (44.5 ± 12.8 vs. 33.6 ± 9.1 mL/cm H2O, p = 0.017). Our data indicated that individualized PEEP guided by EIT without intraoperative recruitment maneuvers also improved perioperative oxygenation in patients undergoing robot-assisted laparoscopic radical prostatectomy, which could benefit patients with the risk of intraoperative hemodynamic instability caused by recruitment maneuvers. Trial registration: China Clinical Trial Registration Center Identifier: ChiCTR2100053839. This study was registered on 1 December 2021. The first patient was recruited on 15 December 2021.
Potential of Porous Substrate Bioreactors for Removal of Pollutants from Wastewater Using Microalgae
Authors: Carbone Dora Allegra , Melkonian Michael
Published: October 2023

Porous substrate bioreactors (PSBRs) are a new technology to grow microalgae immobilized in a dense culture and solve some problems linked to suspended cultivation. During recent years, this technology has been used in laboratory and pilot setups in different fields of environmental biotechnology, such as wastewater treatment. The aim of this short review is to introduce the PSBR technology, summarize the results obtained in removing some pollutants from wastewater, provide an assessment of the potential of PSBRs for wastewater treatment, and the subsequent use of the algal biomass for other purposes.
Pitfalls of Using Multinomial Regression Analysis to Identify Class-Structure-Relevant Variables in Biomedical Data Sets: Why a Mixture of Experts (MOE) Approach Is Better
Authors: Lötsch Jörn , Ultsch Alfred
Published: October 2023

Recent advances in mathematical modeling and artificial intelligence have challenged the use of traditional regression analysis in biomedical research. This study examined artificial data sets and biomedical data sets from cancer research using binomial and multinomial logistic regression. The results were compared with those obtained with machine learning models such as random forest, support vector machine, Bayesian classifiers, k-nearest neighbors, and repeated incremental clipping (RIPPER). The alternative models often outperformed regression in accurately classifying new cases. Logistic regression had a structural problem similar to early single-layer neural networks, which limited its ability to identify variables with high statistical significance for reliable class assignments. Therefore, regression is not per se the best model for class prediction in biomedical data sets. The study emphasizes the importance of validating selected models and suggests that a “mixture of experts” approach may be a more advanced and effective strategy for analyzing biomedical data sets.
Human Operation Augmentation through Wearable Robotic Limb Integrated with Mixed Reality Device
Authors: Jing Hongwei , Zheng Tianjiao , Zhang Qinghua , Sun Kerui , Li Lele , Lai Mingzhu , Zhao Jie , Zhu Yanhe
Published: October 2023

Mixed reality technology can give humans an intuitive visual experience, and combined with the multi-source information of the human body, it can provide a comfortable human–robot interaction experience. This paper applies a mixed reality device (Hololens2) to provide interactive communication between the wearer and the wearable robotic limb (supernumerary robotic limb, SRL). Hololens2 can obtain human body information, including eye gaze, hand gestures, voice input, etc. It can also provide feedback information to the wearer through augmented reality and audio output, which is the communication bridge needed in human–robot interaction. Implementing a wearable robotic arm integrated with HoloLens2 is proposed to augment the wearer’s capabilities. Taking two typical practical tasks of cable installation and electrical connector soldering in aircraft manufacturing as examples, the task models and interaction scheme are designed. Finally, human augmentation is evaluated in terms of task completion time statistics.
A Nanozymatic-Mediated Smartphone Colorimetric Sensing Platform for the Detection of Dimethyl Phthalate (DMP) and Dibutyl Phthalate (DBP)
Authors: Li Wenhui , Zhang Xuecheng , Zhang Haojie , Zhang Cheng , Chen Yingjie , Li Cong , Hu Yonghong , Yu Xiaoping , Zhang Biao , Lin Xiaodong
Published: October 2023

Plasticizers are a type of toxic substance that may remain in food, posing significant health risks including carcinogenic, teratogenic, mutagenic, and other adverse effects. In this study, a novel strategy was employed by combining Pt@Au nanozymes with high catalytic properties to created two catalytic signal probes, designated as Pt@Au@Ab1 and Pt@Au@Ab2, specifically designed for the detection of dimethyl phthalate (DMP) and dibutyl phthalate (DBP). These catalytic signal probes served as the foundation for the development of a colorimetric immunoassay, enabling the simultaneous detection of both DMP and DBP. The colorimetric immunoassay is capable of detecting DMP in the range of 0.5–100 μg/L with a limit of detection as low as 0.1 μg/L and DBP in the range of 1–32 μg/L with a low limit of detection of 0.5 μg/L. The developed immunoassay can be used for the determination of the DMP and DBP in baijiu and plastic bottled drinks. The recovery rate is in the range of 96.4% and 100.5% and the coefficient of variation is between 1.0% and 7.2%. This innovative colorimetric immunoassay offers a robust tool for the simultaneous quantification of DMP and DBP in real samples.
Gender-Based Differential Item Function for the Positive and Negative Semantic Dimensions of the Relationship Satisfaction Scale with Item Response Theory
Authors: Fung Sai-fu , Jin Jiahui
Published: October 2023

Relationship satisfaction is at the core of a robust social life and is essential to mental health. The positive and negative semantic dimensions of the relationship satisfaction (PN-SMD) scale is considered in the field of relationship studies to be a reliable tool for assessing the quality of a person’s interpersonal relationships. This study evaluated the psychometric properties of the PN-SMD scale by conducting multidimensional item response theory (MIRT) and differential item functioning (DIF) analyses, both of which are emerging assessment methods that focus on individual items. We recruited 511 Chinese undergraduate students for this study. Construct validity, internal consistency, and concurrent validity were assessed, and MIRT and DIF analyses were conducted. Five of the 14 items were found to have gender-based DIF traits, affecting the scale’s construct validity. A revised nine-item scale (DIF items excluded) had a significantly better model fit and demonstrated comparable concurrent validity to the original scale. The implications of our results and future research directions are discussed.
Self-Determined Regulation, Achievement Goals and Sport Commitment in Spanish Masters Swimmers
Authors: Simón-Piqueras Juan Ángel , Gil-Madrona Pedro , Zamorano-García David , Torre-Maroto Miriam De La , Fernández-Bustos Juan Gregorio
Published: October 2023

This work analyses the motivational regulation, achievement goals and sport commitment of Spanish Masters swimmers, being the first study of its kind. A total of 211 (106 women and 105 men) Masters swimmers from the Federation of Castilla-La Mancha (Spain) aged between 20 and 74 participated. Each participant completed the Sport Motivation Scale (motivation regulation), the Achievement Goals Questionnaire for Sport (achievement goals) and the Sport Commitment Questionnaire (sport commitment), all validated for the Spanish population. A mixed rANOVA was performed to analyse the results, using sex and age group as covariates, and the different groupings of the sample (weekly training days, weekly training hours and practice of other sports) as between-participants factors. The results showed that the participants presented a predominantly intrinsic–integrated and identified regulation, rather than introjected and external regulation. Mastery goals were more prevalent than performance–approach and performance–avoidance goals. In addition, current sport commitment was high, being greater than future commitment. Pearson’s correlation analysis showed moderate relationships between our variables. We found no influence of either the covariates of sex and age or the grouping variables. These findings serve as the basis for further study of the motivation of Masters swimmers in Spain.
Exploration of Campus Environmental Health Issues and Individual Disparities in Environmental Perceptions Based on Daily Activity Path
Authors: Deng Jie , Chen Bin , Fu Changfeng , Du Jia
Published: October 2023

Individual surveillance methods help identify subtle health risks that may be overlooked in room surveillance. This study aims to investigate campus environmental health issues by tracking university students’ daily exposure processes in their living environment. A field survey was conducted among 58 students at a university in northern China. They were equipped with a “companion data collection device” to record exposure experiences and activity pathways related to light, heat, and air environments. A questionnaire was also administered. Morning exposure to adequate light (Circadian Stimulus ≥ 0.3) increased alertness, but only 57% of undergraduates met this standard, and 67% of those waking up after 8 AM experienced this. People with different preferences chose diverse dining spots, and those favoring “roasted,” “stir-fried,” and “deep-fried” foods encountered higher PM2.5 pollution concentrations during meals. During periods of central heating, there is a trade-off between ventilation and heating efficiency. “Slightly open window” for bedroom ventilation at night resulted in a slight temperature decrease of about 1.2 °C but effectively controlled the increase in CO2 concentrations (about 180 ppm). Companion-type data collection shifts focus from buildings to individuals, providing the means and basis for identifying potential health risks in daily campus life.
Impact of Different Space Types on LEED-NC v3 2009 Gold-Certified Projects in Poland
Authors: Pushkar Svetlana
Published: October 2023

Leadership in Energy and Environmental Design for New Construction and Renovation (LEED-NC), version 3 (v3)-certified projects include at least 13 different space types. However, the impact of space types on LEED certification strategies is not yet fully understood. This study assessed the impact of different building types on achieving LEED-NC v3 categories and credits in gold-certified projects in Poland. The exact Wilcoxon–Mann–Whitney test and Fisher’s exact 2 × 2 with Lancaster’s correction test were used to estimate the difference between four space types (i.e., through pairwise comparison) with small sample sizes (n): industrial manufacturing space (IMS) (n = 9), office space (OS) (n = 7), multi-family residential space (MRS) (n = 6), and lodging space (LS) (n = 8). With these sample sizes, meaningful conclusions could be drawn with these tests. Design structure: IMS and OS refer to two subgroups nested in the production group, while MRS and LS refer to two other subgroups nested in the live group. This design structure was used to perform the logical analysis. The results showed that the number of significant differences (p ≤ 0.05) (i) between two subgroups (IMS vs. OS) within the production group was 1 out of 46, and (ii) between two subgroups (MRS vs. LS) within the living group was 6 out of 46, while (iii) the difference between the production and living groups was 45 out of 184. When comparing the production and living groups, LEED indoor environmental quality credit achievements showed the largest contribution (37%) to the number of significant differences. The practical implication of the study is to offer recommendations on LEED certification strategies for production and living spaces.
Impact of Tunneling on Adjacent Piles Based on the Kerr Foundation Model Considering the Influence of Lateral Soil
Authors: Jia Haipeng , Wang Ning , Ding Haibin , Guan Lingxiao
Published: October 2023

The Kerr foundation model simulates the interaction between piles and soil. Considering the impact of lateral soil displacement on adjacent piles, the lateral displacement and bending moment of the adjacent piles caused by shield tunnel excavation are calculated in detail. Additionally, the reactions of groups of piles are obtained by focusing on the shielding effect of the piles on the soil displacement caused by shield tunnel excavation. The validity of the solutions is verified by comparing the calculated results with the boundary element program GEPAN. Additionally, adjacent pile lateral displacement and bending moment are compared, with and without considering lateral soil effects. Furthermore, this study investigates the influence of various factors, such as soil spring stiffness, pile–tunnel distance, ground loss ratio, and pile diameter on the pile group’s lateral displacement and bending moment. The research findings indicate that increasing the soil spring stiffness or the horizontal distance between the pile and tunnel can reduce the lateral displacement and the bending moment of the pile. On the other hand, as the ground loss ratio gradually increases, the pile lateral displacement and bending moment will also increase. However, when the diameter of the pile grows, the lateral displacement reduces, while the bending moment increases.
Experimental Investigation on Interfacial Defect Detection for SCCS with Different Contact NDT Technical
Authors: Fernandes Fernando Antonio da Silva , Barbar Joseph Salem , Costa Dayriane do Socorro de Oliveira , Rossignolo João Adriano
Published: October 2023

Knowledge about air-incorporating additives in concrete can favor civil construction with structures that are lighter and more economical. This study investigated the production of concretes with the addition of 1 to 3% of air-entraining additive via the Micro-CT imaging technique. From the microtomography obtained, it was possible to obtain two-dimensional and three-dimensional images of the analyzed samples. The analysis of these images, using FEI Avizo 9.0 image processing software, allowed for obtaining the volumes of concrete, mortar, voids, and porosities of concrete mortars, in addition to the quantities, shapes, and dimensions of pores (voids) present in the samples. The air contents of the concrete with incorporated air were higher than the reference concrete, directly proportional to the additive contents used, and very close to the mixes with the same additive contents. Both the standard and modified mixes showed an increase in air content as the additive content increased. The specific mass of the concretes decreased as the additive content increased in the standard and modified concretes. As for consistency, the air-incorporated concretes showed greater slumps compared to the reference concrete and increased as the additive content increased, demonstrating the action of the air-incorporating additive in improving workability.
Experimental Investigation of Beams Reinforced with Carbon 2D-Netzgitterträger Reinforcement
Authors: Ur Rehman Nazaib , Stümpel Marina , Michler Harald , Penzel Paul , Beckmann Birgit , Hahn Lars , Cherif Chokri , Marx Steffen
Published: October 2023

The increasing popularity of carbon-reinforced concrete (CRC) is attributed to its exceptional tensile properties, low density, no corrosion phenomenon, and remarkable flexibility, allowing it to be easily shaped into various forms. However, there is a pressing need to explore this innovative and sustainable alternative to traditional steel reinforcement. This motivates research and investigation of the feasibility of using a special 2D Netzgitterträger (NetzGT) reinforcement system, featuring a net-shaped fabricated textile made of multiple diagonally offset rovings with overlapping edge strands, as a viable alternative to traditional steel reinforcement in concrete beams. This 2D NetzGT reinforcement system has also been transformed into a 3D configuration for the development of a hollow core slab system. It is manufactured from carbon rovings with three different diagonal angles of 50°, 60°, and 70°. Laboratory experiments were conducted to assess the mechanical behavior of beams reinforced with the 2D NetzGT reinforcement. Tensile tests on strands were also performed with an increasing number of overlapped rovings to analyze their tensile strength. Additionally, single yarn pull-out tests were also conducted to examine the influence of the roving angle on the bond strength between the carbon textile roving and the concrete matrix.
Sustainable Design Strategy of Regional Revitalization Based on AHP–FCE Analysis: A Case Study of Qianfeng in Guangzhou
Authors: Chen Tao , Luh Dingbang , Hu Linhui , Liu Jinglin , Chen Huihui
Published: October 2023

As urbanization progresses, large cities continue to attract population, causing depopulation and regional development imbalances, especially in remote rural areas facing sustainability challenges. This study aims to explore local resource potential and assess critical factors for regional revitalization, offering design strategies to promote local sustainability. The study is based on the UN Sustainable Development Goals (SDGs) and assesses the status of regional development through field research. The Delphi method was employed to interview experts and build a multi-tiered sustainable development evaluation indicator framework (Level 1: B1–B3, Level 2: C1–C8, Level 3: D1–D16), covering economic, social, and environmental dimensions. The weights of the indicators were determined through the analytic hierarchy process (AHP), and the fuzzy comprehensive evaluation (FCE) method was applied to comprehensively assess the sustainable development status of Qianfeng Community. The research findings revealed that due to population outflow and a lack of participation in co-building channels, the region scored lowest in “local employment & entrepreneurship (D2)”, “innovation & entrepreneurship culture (D10)”, and “endogenous development (D16)”. Consequently, the study proposes the establishment of a regional revitalization co-creation platform based on “life projects” as part of a sustainable design strategy. These research results provide valuable case studies and strategic references for future regional revitalization and sustainable design initiatives.
Decoding Diffuse Midline Gliomas: A Comprehensive Review of Pathogenesis, Diagnosis and Treatment
Authors: Al Sharie Sarah , Abu Laban Dima , Al-Hussaini Maysa
Published: October 2023

Diffuse midline gliomas (DMGs) are a group of aggressive CNS tumors, primarily affecting children and young adults, which have historically been associated with dismal outcomes. As the name implies, they arise in midline structures in the CNS, primarily in the thalamus, brainstem, and spinal cord. In more recent years, significant advances have been made in our understanding of DMGs, including molecular features, with the identification of potential therapeutic targets. We aim to provide an overview of the most recent updates in the field of DMGs, including classification, molecular subtypes, diagnostic techniques, and emerging therapeutic strategies including a review of the ongoing clinical trials, thus providing the treating multidisciplinary team with a comprehensive understanding of the current landscape and potential therapeutic strategies for this devastating group of tumors.
Randomized Phase 2 Clinical Trial of Olaratumab in Combination with Gemcitabine and Docetaxel in Advanced Soft Tissue Sarcomas
Authors: Attia Steven , Villalobos Victor , Hindi Nadia , Wagner Andrew J. , Chmielowski Bartosz , Oakley Gerard J. , Peterson Patrick M. , Ceccarelli Matteo , Jones Robin L. , Dickson Mark A.
Published: October 2023

Gemcitabine plus docetaxel is an effective treatment regimen for advanced soft tissue sarcomas (STSs). However, the prognosis for patients remains poor, and thus there is an urgent medical need for novel and effective therapies to improve long-term outcomes. The aim of the ANNOUNCE 2 trial was to explore the addition of olaratumab (O) to gemcitabine (G) and docetaxel (D) for advanced STS. Adults with unresectable locally advanced/metastatic STS, ≤2 prior lines of systemic therapy, and ECOG PS 0–1 were eligible. In Phase 2, patients were randomized 1:1 from two cohorts (O-naïve and O-pretreated) to 21-day cycles of olaratumab (20 mg/kg Cycle 1 and 15 mg/kg other cycles, Days 1 and 8), gemcitabine (900 mg/m2, Days 1 and 8), and docetaxel (75 mg/m2, Day 8). The primary objective was overall survival (OS) in the O-naïve population (α level = 0.20). Secondary endpoints included OS (O-pretreated), other efficacy parameters, patient-reported outcomes, safety, pharmacokinetics, and immunogenicity. A total of 167 and 89 patients were enrolled in the O-naïve and O-pretreated cohorts, respectively. Baseline patient characteristics were well balanced. No statistically significant difference in OS was observed between the investigational vs. control arm for either cohort (O-naïve cohort: HR = 0.95 (95% CI: 0.64−1.40), p = 0.78, median OS, 16.8 vs. 18.0 months; O-pretreated cohort: HR = 0.67 (95% CI: 0.39−1.16), p = 0.15, median OS 19.8 vs. 17.3 months). Safety was manageable across treatment arms. There was no statistically significant difference in the primary endpoint of OS between the two arms in the O-naïve population, and therefore based on hierarchical evaluation no other outcomes in this study can be considered statistically significant. No new safety signals were observed.
The Gut Microbiome as a Biomarker and Therapeutic Target in Hepatocellular Carcinoma
Authors: Gok Yavuz Betul , Datar Saumil , Chamseddine Shadi , Mohamed Yehia I. , LaPelusa Michael , Lee Sunyoung S. , Hu Zishuo Ian , Koay Eugene J. , Tran Cao Hop S. , Jalal Prasun Kumar , Daniel-MacDougall Carrie , Hassan Manal , Duda Dan G. , Amin Hesham M. , Kaseb Ahmed O.
Published: October 2023

The microbiome is pivotal in maintaining health and influencing disease by modulating essential inflammatory and immune responses. Hepatocellular carcinoma (HCC), ranking as the third most common cause of cancer-related fatalities globally, is influenced by the gut microbiome through bidirectional interactions between the gut and liver, as evidenced in both mouse models and human studies. Consequently, biomarkers based on gut microbiota represent promising non-invasive tools for the early detection of HCC. There is a growing body of evidence suggesting that the composition of the gut microbiota may play a role in the efficacy of immunotherapy in different types of cancer; thus, it could be used as a predictive biomarker. In this review, we will dissect the gut microbiome’s role as a potential predictive and diagnostic marker in HCC and evaluate the latest progress in leveraging the gut microbiome as a novel therapeutic avenue for HCC patients, with a special emphasis on immunotherapy.
Extracellular Vesicles in Triple–Negative Breast Cancer: Immune Regulation, Biomarkers, and Immunotherapeutic Potential
Authors: Das Kaushik , Paul Subhojit , Ghosh Arnab , Gupta Saurabh , Mukherjee Tanmoy , Shankar Prem , Sharma Anshul , Keshava Shiva , Chauhan Subhash C. , Kashyap Vivek Kumar , Parashar Deepak
Published: October 2023

Triple–negative breast cancer (TNBC) is an aggressive subtype accounting for ~10–20% of all human BC and is characterized by the absence of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) amplification. Owing to its unique molecular profile and limited targeted therapies, TNBC treatment poses significant challenges. Unlike other BC subtypes, TNBC lacks specific molecular targets, rendering endocrine therapies and HER2–targeted treatments ineffective. The chemotherapeutic regimen is the predominant systemic treatment modality for TNBC in current clinical practice. However, the efficacy of chemotherapy in TNBC is variable, with response rates varying between a wide range of patients, and the emerging resistance further adds to the difficulties. Furthermore, TNBC exhibits a higher mutational burden and is acknowledged as the most immunogenic of all BC subtypes. Consequently, the application of immune checkpoint inhibition has been investigated in TNBC, yielding promising outcomes. Recent evidence identified extracellular vesicles (EVs) as an important contributor in the context of TNBC immunotherapy. In view of the extraordinary ability of EVs to transfer bioactive molecules, such as proteins, lipids, DNA, mRNAs, and small miRNAs, between the cells, EVs are considered a promising diagnostic biomarker and novel drug delivery system among the prospects for immunotherapy. The present review provides an in–depth understanding of how EVs influence TNBC progression, its immune regulation, and their contribution as a predictive biomarker for TNBC. The final part of the review focuses on the recent key advances in immunotherapeutic strategies for better understanding the complex interplay between EVs and the immune system in TNBC and further developing EV–based targeted immunotherapies.
Combined PI3K Inhibitor and Eribulin Enhances Anti-Tumor Activity in Preclinical Models of Paclitaxel-Resistant, PIK3CA-Mutated Endometrial Cancer
Authors: Jeong Yeong Gyu , Katuwal Nar Bahadur , Kang Min Sil , Ghosh Mithun , Hong Sa Deok , Park Seong Min , Kim Seul-Gi , Kim Tae Hoen , Moon Yong Wha
Published: October 2023

Endometrial cancer stands as the predominant gynecological malignancy in developed nations. For advanced or recurrent disease, paclitaxel-based chemotherapy is the standard front-line therapy. However, paclitaxel resistance eternally develops. Based on the high prevalence of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) mutation, reaching 50%, in endometrial cancer, we preclinically investigated the effectiveness of a combination of a phosphatidylinositol 3-kinase (PI3K) inhibitor with eribulin, a post-paclitaxel therapy for breast cancer, in treating paclitaxel-resistant, PIK3CA-mutated endometrial cancer. We generated paclitaxel-resistant cell lines from PIK3CA-mutated endometrial cancer cell lines by gradually increasing the concentration of paclitaxel in cell cultures. We observed that the PI3K/AKT and epithelial–mesenchymal transition (EMT) pathways in paclitaxel-resistant cells were significantly upregulated compared with those in parental cells. Then, we demonstrated that the combination of alpelisib (a PI3K inhibitor) and eribulin more effectively suppressed the cellular growth of paclitaxel-resistant cells in in vitro and in vivo xenograft models. Mechanistically, we demonstrated that the effect of the combination could be enhanced by inhibiting both the PI3K/AKT and EMT pathways. Therefore, we suggest that paclitaxel resistance is associated with the activation of the PIK3/AKT pathway in PIK3CA-mutated endometrial cancer, and the combination of a PI3K inhibitor and eribulin merits further clinical investigation.
Intraoperative Imaging and Optical Visualization Techniques for Brain Tumor Resection: A Narrative Review
Authors: Bin-Alamer Othman , Abou-Al-Shaar Hussam , Gersey Zachary C. , Huq Sakibul , Kallos Justiss A. , McCarthy David J. , Head Jeffery R. , Andrews Edward , Zhang Xiaoran , Hadjipanayis Constantinos G.
Published: October 2023

Advancements in intraoperative visualization and imaging techniques are increasingly central to the success and safety of brain tumor surgery, leading to transformative improvements in patient outcomes. This comprehensive review intricately describes the evolution of conventional and emerging technologies for intraoperative imaging, encompassing the surgical microscope, exoscope, Raman spectroscopy, confocal microscopy, fluorescence-guided surgery, intraoperative ultrasound, magnetic resonance imaging, and computed tomography. We detail how each of these imaging modalities contributes uniquely to the precision, safety, and efficacy of neurosurgical procedures. Despite their substantial benefits, these technologies share common challenges, including difficulties in image interpretation and steep learning curves. Looking forward, innovations in this field are poised to incorporate artificial intelligence, integrated multimodal imaging approaches, and augmented and virtual reality technologies. This rapidly evolving landscape represents fertile ground for future research and technological development, aiming to further elevate surgical precision, safety, and, most critically, patient outcomes in the management of brain tumors.
Enhancing Healthcare for Sarcoma Patients: Lessons from a Diagnostic Pathway Efficiency Analysis
Authors: Elyes Maria , Heesen Philip , Schelling Georg , Bode-Lesniewska Beata , Studer Gabriela , Fuchs Bruno
Published: October 2023

Sarcomas, rare and with lower survival rates than common tumors, offer insights into healthcare efficiency via the analysis of the total interval of the diagnostic pathway, combining the patient interval (time between the first symptom and visit with a physician) and diagnostic interval (time between first physician visit and histological diagnosis). Switzerland’s healthcare system, Europe’s costliest, lacks research on treating rare conditions, like mesenchymal tumors. This study examines the total interval of the diagnostic pathway for optimization strategies. Analyzing a dataset of 1028 patients presented from 2018 to 2021 to the Swiss Sarcoma Board (MDT/SB-SSN), this retrospective analysis delves into bone sarcoma (BS), soft-tissue sarcoma (STS), and their benign counterparts. Demographic and treatment data were extracted from medical records. The patient interval accounted for the largest proportion of the total interval and secondary care interval for the largest proportion of the diagnostic interval. Age, grade, and localization could be elicited as influencing factors of the length of different components of the total interval. An increasing age and tumor size, as well as the axial localization, could be elicited as factors increasing the probability of sarcoma. The patient and secondary care interval (SCI) offer the greatest potential for optimization, with SCI being the bottleneck of the diagnostic interval. New organizational structures for care work-ups are needed, such as integrated practice units (IPU) as integral part of value-based healthcare (VBHC).
Efficacy and Safety of Daratumumab, Pomalidomide, and Dexamethasone (DPd) Compared to Daratumumab, Bortezomib, and Dexamethasone (DVd) in Daratumumab–Naïve Relapsed Multiple Myeloma
Authors: Afrough Aimaz , Atrash Shebli , Paul Barry , Ouchveridze Evguenia , Ahmed Nausheen , Mahmoudjafari Zahra , Bashir Anam , Alkharabsheh Omar , Hashmi Hamza , Abdallah Al-Ola
Published: October 2023

Daratumumab-based combinations with pomalidomide/dexamethasone (DPd), or bortezomib/dexamethasone (DVd), have shown activity in relapsed/refractory multiple myeloma (RRMM) patients. However, no direct comparisons of safety or efficacy of the two regimens have been published to date. We conducted a retrospective study to compare the safety and efficacy of DPd and DVd in daratumumab-naïve RRMM patients. We included 140 daratumumab-naïve patients who had received DPd or DVd for RRMM. Overall, the DPd group had a greater number of patients who had high-risk disease characteristics. Although response was deeper in the DPd group, the median progression-free survival (PFS) and overall survival (OS) were similar between the two groups. The DPd group exhibited a higher incidence of hematologic toxicities, whereas the DVd group had a higher incidence of peripheral neuropathy. The study results showed that while DPd may provide a deeper response, there was no significant difference in PFS or OS compared to DVd. For the high proportion of difficult-to-treat patients, duration of treatment may have contributed to these results, indicating that patient and disease characteristics should be considered when selecting salvage treatments.
Clinical Characteristics and Treatment Outcomes of Oral Cancers Using Transoral Robotic Surgery in an Endemic Region
Authors: Chang Chia-Chun , Chen Chung-Hsiung , Hsieh Tsai-Ling , Chang Kuang-Hsi , Huang Jing-Yang , Lin Frank Cheau-Feng , Tsai Stella Chin-Shaw
Published: October 2023

Oral cancer poses a major health challenge in Taiwan, consistently ranking among the highest globally in both incidence and cancer-related mortality. Transoral robotic surgery (TORS) has potential advantages over open surgery, but its long-term oncologic outcomes are not well established. In this study, we sought to elucidate the role of TORS in improving treatment outcomes among oral cancer patients. A case–control study with propensity score matching was conducted in a single teaching hospital in Taiwan. It included 72 oral cancer patients in each group to analyze and compare survival outcomes between the surgical approaches. The TORS group demonstrated a higher negative resection margin rate, a lower mortality risk and better overall survival than the open-surgery group. Multivariate Cox regression analysis confirmed TORS’s association with a reduced risk of death. Kaplan–Meier survival analysis and log-rank tests indicated significantly better survival outcomes for the TORS group across all cancer stages. Moreover, the TORS group exhibited improved overall survival rates for stage III and IV patients compared to the conventional open-surgery group. In conclusion, this study suggests that TORS may offer better overall survival rates and potential advantages over conventional surgery for oral cancer treatment.