bluuebunny/crossref_metadata_2025 huggingface dataset:
Siamese neural networks for continuous disease severity evaluation and change detection in medical imaging
Authors: Li Matthew D. , Chang Ken , Bearce Ben , Chang Connie Y. , Huang Ambrose J. , Campbell J. Peter , Brown James M. , Singh Praveer , Hoebel Katharina V. , Erdoğmuş Deniz , Ioannidis Stratis , Palmer William E. , Chiang Michael F. , Kalpathy-Cramer Jayashree
Published: March 2020

Using medical images to evaluate disease severity and change over time is a routine and important task in clinical decision making. Grading systems are often used, but are unreliable as domain experts disagree on disease severity category thresholds. These discrete categories also do not reflect the underlying continuous spectrum of disease severity. To address these issues, we developed a convolutional Siamese neural network approach to evaluate disease severity at single time points and change between longitudinal patient visits on a continuous spectrum. We demonstrate this in two medical imaging domains: retinopathy of prematurity (ROP) in retinal photographs and osteoarthritis in knee radiographs. Our patient cohorts consist of 4861 images from 870 patients in the Imaging and Informatics in Retinopathy of Prematurity (i-ROP) cohort study and 10,012 images from 3021 patients in the Multicenter Osteoarthritis Study (MOST), both of which feature longitudinal imaging data. Multiple expert clinician raters ranked 100 retinal images and 100 knee radiographs from excluded test sets for severity of ROP and osteoarthritis, respectively. The Siamese neural network output for each image in comparison to a pool of normal reference images correlates with disease severity rank (ρ = 0.87 for ROP and ρ = 0.89 for osteoarthritis), both within and between the clinical grading categories. Thus, this output can represent the continuous spectrum of disease severity at any single time point. The difference in these outputs can be used to show change over time. Alternatively, paired images from the same patient at two time points can be directly compared using the Siamese neural network, resulting in an additional continuous measure of change between images. Importantly, our approach does not require manual localization of the pathology of interest and requires only a binary label for training (same versus different). The location of disease and site of change detected by the algorithm can be visualized using an occlusion sensitivity map-based approach. For a longitudinal binary change detection task, our Siamese neural networks achieve test set receiving operator characteristic area under the curves (AUCs) of up to 0.90 in evaluating ROP or knee osteoarthritis change, depending on the change detection strategy. The overall performance on this binary task is similar compared to a conventional convolutional deep-neural network trained for multi-class classification. Our results demonstrate that convolutional Siamese neural networks can be a powerful tool for evaluating the continuous spectrum of disease severity and change in medical imaging.
Machine learning prediction of incidence of Alzheimer’s disease using large-scale administrative health data
Authors: Park Ji Hwan , Cho Han Eol , Kim Jong Hun , Wall Melanie M. , Stern Yaakov , Lim Hyunsun , Yoo Shinjae , Kim Hyoung Seop , Cha Jiook
Published: March 2020

Nationwide population-based cohort provides a new opportunity to build an automated risk prediction model based on individuals’ history of health and healthcare beyond existing risk prediction models. We tested the possibility of machine learning models to predict future incidence of Alzheimer’s disease (AD) using large-scale administrative health data. From the Korean National Health Insurance Service database between 2002 and 2010, we obtained de-identified health data in elders above 65 years (N = 40,736) containing 4,894 unique clinical features including ICD-10 codes, medication codes, laboratory values, history of personal and family illness and socio-demographics. To define incident AD we considered two operational definitions: “definite AD” with diagnostic codes and dementia medication (n = 614) and “probable AD” with only diagnosis (n = 2026). We trained and validated random forest, support vector machine and logistic regression to predict incident AD in 1, 2, 3, and 4 subsequent years. For predicting future incidence of AD in balanced samples (bootstrapping), the machine learning models showed reasonable performance in 1-year prediction with AUC of 0.775 and 0.759, based on “definite AD” and “probable AD” outcomes, respectively; in 2-year, 0.730 and 0.693; in 3-year, 0.677 and 0.644; in 4-year, 0.725 and 0.683. The results were similar when the entire (unbalanced) samples were used. Important clinical features selected in logistic regression included hemoglobin level, age and urine protein level. This study may shed a light on the utility of the data-driven machine learning model based on large-scale administrative health data in AD risk prediction, which may enable better selection of individuals at risk for AD in clinical trials or early detection in clinical settings.
A versatile and multifunctional metal–organic framework nanocomposite toward chemo-photodynamic therapy
Authors: Pan Ying , Luo Zhidong , Wang Xiaoxiong , Chen Qianyi , Chen Junhao , Guan Yucheng , Liu Dong , Xu Hongjia , Liu Jianqiang
Published: March 2020

We synthesize a new carrier of ALA@UIO-66-NH-FAM/MTA to achieve efficient synergistic therapy, taking advantage of the targeting component of MTA and high drug-loading capacity of hybrid scaffolds of MOF.
Multi-nuclear, high-pressure, operando FlowNMR spectroscopic study of Rh/PPh3 – catalysed hydroformylation of 1-hexene
Authors: Bara-Estaún Alejandro , Lyall Catherine L. , Lowe John P. , Pringle Paul G. , Kamer Paul C. J. , Franke Robert , Hintermair Ulrich
Published: March 2020

The hydroformylation of 1-hexene with 12 bar of 1 : 1 H2/CO in the presence of the catalytic system [Rh(acac)(CO)2]/PPh3 was successfully studied by real-time multinuclear high-resolution FlowNMR spectroscopy at 50 °C.
Resilient hollow fiber nanofiltration membranes fabricated from crosslinkable phase-separated copolymers
Authors: Dugas Michael P. , Van Every Graham , Park Bumjun , Hoffman John R. , LaRue Ryan J. , Bush Aaron M. , Zhang Yizhou , Schaefer Jennifer L. , Latulippe David R. , Phillip William A.
Published: March 2020

Hollow fiber nanofiltration membranes are fabricated from a copolymer designed to withstand exposure to solvents and chlorine.
A turn-off fluorescent probe for the detection of Cu2+based on a tetraphenylethylene-functionalized salicylaldehyde Schiff-base
Authors: Xie Hai-Fang , Yu Chang-Jin , Huang Ya-Li , Xu Hong , Zhang Qi-Long , Sun Xiao-Hong , Feng Xing , Redshaw Carl
Published: March 2020

A tetraphenylethylene-functionalized salicylaldehyde Schiff-base fluorescent probe (TPE-An-Py) with aggregation-induced enhanced emission (AIEE) characteristics exhibited high sensitivity towards copper(ii) ions in aqueous media with a “turn-off” fluorescence mechanism; limit of detection is 2.36 × 10−7mol L−1.
How clay particulates affect flow cessation and the coiling stability of yield stress-matched cementing suspensions
Authors: Mehdipour Iman , Atahan Hakan , Neithalath Narayanan , Bauchy Mathieu , Garboczi Edward , Sant Gaurav
Published: March 2020

Transition from closely-packed to fractally-architected structures with clay addition improves homogeneity and prevents local dewatering, thus enhancing coiling stability of layer-wise extruded cementing suspensions during 3D-printing.
The axial chirality hidden in vitamin D and its application in cocrystal prediction
Authors: Guo Mengfei , Zhang Zaiyong , Chen Zhaoqiang , Ding Qiaoce , Lu Liye , Zhang Qi , Wang Jian-Rong , Mei Xuefeng
Published: March 2020

An ECD titration method was developed to detect hydrogen-bonding interaction in solution and to predict cocrystal formation in the solid state.
Spatially resolved stoichiometry determination of Li7La3Zr2O12 solid-state electrolytes using LA-ICP-OES
Authors: Smetaczek Stefan , Bonta Maximilian , Wachter-Welzl Andreas , Taibl Stefanie , Wagner Reinhard , Rettenwander Daniel , Fleig Jürgen , Limbeck Andreas
Published: March 2020

LA-ICP-OES in combination with matrix-matched calibration standards and proper signal normalization enables reliable laterally resolved stoichiometry determination of Al stabilized LLZO (Li7−3xAlxLa3Zr2O12) solid electrolytes.
Superfast and controllable microfluidic inking of anti-inflammatory melanin-like nanoparticles inspired by cephalopods
Authors: Wang Shiqi , Wannasarit Saowanee , Figueiredo Patrícia , Li Jiachen , Correia Alexandra , Xia Bing , Wiwattanapatapee Ruedeekorn , Hirvonen Jouni , Liu Dongfei , Li Wei , Santos Hélder A.
Published: March 2020

We report a microfluidic approach for superfast melanin-like nanoparticle preparation with tunable size and monodispersity.
“Living” luminogens: light driven ACQ-to-AIE transformation accompanied with solid-state actuation
Authors: Wang Haoran , Xing Hao , Gong Junyi , Zhang Haoke , Zhang Jun , Wei Peifa , Yang Guojian , Lam Jacky W. Y. , Lu Ran , Tang Ben Zhong
Published: March 2020

In situ ACQ-to-AIE transformation was achieved by light-induced [2+2] cycloaddition via through-space conjugation.
Rapid naked-eye colorimetric detection of gaseous alkaline analytes using rhodamine B hydrazone-coated silica strips
Authors: Nour Hany F. , El Malah Tamer
Published: March 2020

Development of rhodamine B hydrazone-coated silica strips for rapid detection of alkaline vapors by the naked-eye or using a smartphone camera.
Photoelectrochemical photocurrent switching effect on a pristine anodized Ti/TiO2 system as a platform for chemical logic devices
Authors: Ryzhkov Nikolay V. , Yurova Veronika Yu. , Ulasevich Sviatlana A. , Skorb Ekaterina V.
Published: March 2020

We report here the effect of the photoelectrochemical photocurrent switching (PEPS) observed on highly-ordered pristine anodized Ti/TiO2 for the first time.
Carbamoyl-N-aryl-imine-urea: a new framework to obtain a putative leishmanicidal drug-candidate
Authors: Alves Marina A. , de Queiroz Aline C. , Leite Anderson Brandão , Martins Felipe T. , Doriguetto Antonio C. , Barreiro Eliezer J. , Alexandre-Moreira Magna S. , Lima Lídia M.
Published: March 2020

LASSBio-1736 was identified as a new antileishmanial drug-candidate bearing an original framework and displaying plasma stability, cytotoxicity against amastigote forms of Leishmania species and leishmanicidal activity in a cutaneous leishmaniasis murine model.
Omni-direction PERC solar cells harnessing periodic locally focused light incident through patterned PDMS encapsulation
Authors: Yun Min Ju , Sim Yeon Hyang , Lee Dong Y. , Cha Seung I.
Published: March 2020

Enhancing energy production of PERC solar cells with periodic locally focused light by using patterned PDMS encapsulation.
Crystal structure evolution of an energetic compound dihydroxylammonium 5,5′-bistetrazole-1,1′-diolate induced by solvents
Authors: Xu Xin , Chen Dong , Li Hongzhen , Yan Mi , Xiong Ying , Zhao Haixia , Xu Rong
Published: March 2020

Three new solvent compounds obtained by dihydroxylammonium 5,5′-bistetrazole-1,1′-diolate recrystallized from three solvents.
Surface states mediated charge transfer in redox behavior of hemin at GaAs(100) electrodes
Authors: Enache Mirela , Negrila Catalin , Lazarescu Valentina
Published: March 2020

Paper brings evidence that surface states are responsible for different redox processes of hemin, reversible at p-GaAs(100) and ireversible at n-GaAs(100).
A 3D nitrogen-doped graphene aerogel for enhanced visible-light photocatalytic pollutant degradation and hydrogen evolution
Authors: Maouche Chanez , Zhou Yazhou , Peng Jinjun , Wang Shuang , Sun Xiujuan , Rahman Nasir , Yongphet Piyaphong , Liu Qinqin , Yang Juan
Published: March 2020

The synergistic effect of the 3D structure and N-doping explain the high surface area of 536 m2g−1and excellent photocatalytic activity.
Poly(fluorenone-co-thiophene)-based nanoparticles for two-photon fluorescence imaging in living cells and tissues
Authors: Du Nan , Tan Ying , Zhang Chen , Tan Chunyan
Published: March 2020

Novel conjugate polymer nanoparticles (CPNs) based on poly(fluorenone-co-thiophenes) (PFOTs) were constructed for two-photon cell and tissue fluorescence imaging.
The synergetic effects of a multifunctional citric acid and rice husk derived honeycomb carbon matrix on a silicon anode for high-performance lithium ion batteries
Authors: Wang Yong , Wang Xiaolan , Jin Hong , Bai Yu , Xu Hui
Published: March 2020

Using silicon/carbon composites is one of the most attractive strategies to improve the anode performance for lithium ion batteries.
Ferroelectricity in a lead free organic–inorganic 0D hybrid: formamidinium bromoantimonate(iii)
Authors: Mencel K. , Gągor A. , Jakubas R. , Ciżman A. , Medycki W. , Zaręba J. K. , Piecha-Bisiorek A.
Published: March 2020

A multiphase, low-temperature ferroelectric of haloantimonate(iii) with a unique R5M2X11 composition and Ps of about 3 μC cm−2 resulting from the ‘order–disorder’ and ‘displacive’ molecular mechanism is successfully synthesized and characterized.
Investigation of overall and local vibration characteristics of disk‐type windings
Authors: Zhang Fan , Ji Shengchang , Naranpanawe Lakshitha , Ma Hui , Ekanayake Chandima , Saha Tapan , Zhu Lingyu
Published: March 2020

This study investigates the overall and local vibration characteristics of disk‐type windings in power transformers. The influence of clamping pressure relaxation and pressboard aging on windings' overall modal characteristics is studied. Individual conductors in a winding can vibrate independently and have the local vibration from that of overall windings. The local vibration characteristics of conductors under hoop tension, axial bending and the loss of clamping pressure are investigated. It is found that the clamping pressure relaxation and pressboard aging lead to the decrease of natural frequencies but the faulty conductors result in the increasing number of natural frequencies.
Suppressing ineffective control actions in optimal power flow problems
Authors: Capitanescu Florin
Published: March 2020

Many utilities are still reluctant in adopting optimal power flow (OPF) tools for decision‐making in operation. This paper scrutinizes this issue from the perspective of whether all control actions proposed by an OPF are truly effective to an operator. To this end, the paper focuses on suppressing ineffective control actions in OPF problems. This goal is aligned with the meaning of optimization in practice, that is improvement of operation performance of slightly noisy or imperfectly known real world models. The paper proposes a conceptually different new approach, which computes automatically the number of effective control actions that do not worsen the ideal model OPF objective by more than an operator‐specified tolerance. The proposed approach relies on a three‐step methodology that solves different OPF problems, in which smooth continuous approximation functions are used to convert the benchmark mixed integer nonlinear programming (MINLP) problems into nonlinear programming (NLP) problems. The proposed approach is compared with two other alternatives for the OPF problem of thermal congestion management using three test systems of 60, 118, and 2746 buses, respectively. The results show that, among the competing approaches, the solutions of the proposed continuous approximation lead to the best trade‐off between sub‐optimality and computation speed.
Improved robust‐mixed‐norm‐based controller for grid‐tied PV systems under voltage disturbances
Authors: Kumar Ajay , Gupta Vikas , Patel Nirav , Gupta Nitin , Babu B. Chitti
Published: March 2020

The grid‐tied solar photovoltaic system requires a multiobjective control approach for performing the dual operation of active power transfer at unity power factor and harmonic filtering. In this context, this study proposes an improved robust‐mixed‐norm (RMN) filter‐based multiobjective control strategy for integrating the solar photovoltaic system with the utility grid. The standard RMN filtering control exhibits slow convergence, requires large sampling time and involves high computational cost. Therefore, a switching parameter is designed to toggle between least mean square and least absolute deviation for extracting the benefits of both filtering techniques as per requirement. The switching parameter will also help in minimising the computational intensiveness during hardware implementation and successfully confronts the conflict between convergence speed and steady‐state misadjustment in the presence of outliers. The proposed control is implemented with the help of multiple delayed input vectors to extract the fundamental weight component from the non‐sinusoidal load current. In addition, the effects of grid voltage distortion and imbalance have been detached by using complex vector filter‐based synchronisation technique. The practicality of the proposed multiobjective approach has been verified under different operating conditions of supply and load through both MATLAB/Simulink tool and low‐cost microcontroller‐STM32F407VGT6‐based laboratory prototype.
High step‐up double input converter with soft switching and reduced number of semiconductors
Authors: Dobakhshari Sina Salehi , Fathi Seyyed Hamid , Milimonfared Jafar
Published: March 2020

A novel semi‐isolated high step‐up double‐input converter with current‐fed inputs is introduced in this study. The proposed converter can operate in double‐input mode and single‐input mode. It can manage the collected power from both inputs effectively. In addition, it makes a gentle transition between the modes, without the need for an abrupt change in pulse pattern, and does not utilise a breaker switch. Meanwhile, the converter preserves soft‐switching as well as a few number of semiconductors (three switches and three diodes). These items have improved the efficiency of the converter to 94.5%. Moreover, it is a high‐voltage gain (more than 13). Also, both input ports are current‐fed, so the input currents are smoothed. These features make the converter compatible with hybrid renewable energy applications. Furthermore, all components are engaged in both modes, which results in an improved component's utilisation factor. A thorough analysis has been conducted to prove the characteristics mentioned above of the proposed converter. Theoretical analysis has been verified by simulation and experimental results of a 200 W prototype.
Recent progress of graphene orientation determination technology based on scanning probe microscopy
Authors: Zhang Yu , Liu Guangjie , Xu Wenjing
Published: March 2020

Graphene is regarded as an excellent substitute for silicon and an ideal chip material for the next generation of chip manufacturing. Researches show that the electrical properties of graphene are closely related to its edge structures. Graphene can exhibit metal or semiconductive characteristics according to the different edge configurations. How to fabricate graphene nanoribbons with specific edge structures is the key premise for practical applications. The review highlights the new graphene crystal orientation detection methods based on scanning probe technology, including offline detection technology and online detection technology. The advantages and disadvantages of different detection technologies are analysed, and finally, a brief outlook for the development of graphene orientation determination techniques is given.
Rotation-activity relations and flares of M dwarfs with K2 long- and short-cadence data
Authors: Raetz St. , Stelzer B. , Damasso M. , Scholz A.
Published: March 2020

Using light curves obtained by the K2 mission, we study the relation between stellar rotation and magnetic activity with special focus on stellar flares. Our sample comprises 56 bright and nearby M dwarfs observed by K2 during campaigns C0-C18 in long- and short-cadence mode. We derive rotation periods for 46 M dwarfs and measure photometric activity indicators such as amplitude of the rotational signal, standard deviation of the light curves, and the basic flare properties (flare rate, flare energy, flare duration, and flare amplitude). We found 1662 short-cadence flares, 363 of which have a long-cadence counterpart with flare energies of up to 5.6 × 1034erg. The flare amplitude, duration, and frequency derived from the short-cadence light curves differ significantly from those derived from the long-cadence data. The analysis of the short-cadence light curves results in a flare rate that is 4.6 times higher than the long-cadence data. We confirm the abrupt change in activity level in the rotation-activity relation at a critical period of ~10 d when photometric activity diagnostics are used. This change is most drastic in the flare duration and frequency for short-cadence data. Our flare studies revealed that the highest flare rates are not found among the fastest rotators and that stars with the highest flare rates do not show the most energetic flares. We found that the superflare frequency (E≥ 5 × 1034erg) for the fast-rotating M stars is twice higher than for solar like stars in the same period range. By fitting the cumulative FFD, we derived a power-law index ofα= 1.84 ± 0.14, consistent with previous M dwarf studies and the value found for the Sun.
Development of media education in Canada: a brief history
Authors: Tsvietkova Hanna , Beskorsa Olena , Pryimenko Liudmyla
Published: March 2020

The article focuses on a holistic retrospective analysis of the history of media education in Canada, which has been done for the first time. Based on the theoretical findings of Canadian media educators, the authors substantiate the periodization, identify the trends, the periodization criteria and three main periods of establishment and development of Canadian media education in the context of sociopolitical and socio-pedagogical determinants. The historical preconditions of the development of media education in Canada are revealed. The essence of media education is regarded as a theory study and development of practical skills for mastering modern mass media, which is considered as part of a specific, autonomous field of knowledge in pedagogical theory and practice. The authors determine that media education is associated with all types of media, which include the set of information and communication tools that each person interacts with in everyday life: printed (newspapers, magazines), auditive (radio, audio) and screen or audiovisual media (cinema, TV, video, multimedia, Internet, etc.); they identify the essential characteristics of media education, determine that media education is the form of media literacy and media culture of an individual; as well as they find out, characterize and systematize the gaps in media education in Canada. The article presents the evolution of media education programs, techniques as well as media education associations. In the context of studying the experience of Canadian media theorists and practitioners, the necessity of applying positive Canadian experience to solve the problems of implementing media education in Ukraine in terms of reforming and humanizing its educational space has been substantiated.
The research on educational environment of institution of higher education involving experts: results and analysis
Authors: Bratko Mariia , Khoruzha Liudmyla
Published: March 2020

Based on the analysis of scientific resources, the role of educational environment in personal building, development and education is actualized. It is stated that educational environment is one of the most essential factors of those processes. The author’s definitions of notions “educational environment”, “educational environment of institution of higher education” are given. The authors advocate the point that educational environment is a system of facilities for personal education. It is emphasized that the environmental approach in education is changing accents in teaching which is aimed at creating and developing educational environment, which has to meet educational needs of a student. The author’s technique of evaluating the state of educational environment of institution of higher education is grounded and approved, the rating scale of this technique is introduced. The technique suggests making expert evaluation of educational environment of institution of higher education according to qualitative (modality) and quantitative (professional breadth, professional saturation, sociocultural intensity, congruence, openness, mobility, informativeness) parameters. The typology of educational environment of institution of higher education is presented (innovative-professional, formal-professional, pragmatically-oriented, formal general cultural educational environment). The analysis and interpretation of the results obtained from the experiment at University College of Borys Grinchenko Kyiv University are given. The evaluation of educational environment of the college has been made by three groups of experts, which have included students, teachers and parents. Despite the fact that evaluation by different groups of experts are similar, it is revealed that it has essential differences, which has been proved with appropriate statistical methods. It is determined that the substantiation of the whole monitoring system of educational environment of institution of higher education and corresponding diagnostic tools has great potential.
Managing the development of training of competitive professionals in vocational educational institutions
Authors: Sergeeva Larisa , Stoychik Tatiana
Published: March 2020

Significant transformation processes in Ukraine, inspired by globalization, require a rethinking of educational goals, objectives, and educational imperatives. Within the educational process in vocational (vocational-technical) educational institutions, the training system is forced to take into account the global context of actions and consequences in the preparation of a competitive specialist. The purpose of this article is to analyze the current state of development of vocational (vocational-technical) education in Ukraine and the network of institutions of vocational (vocational-technical) education; identifying factors that affect the quality of training of a competitive specialist and controversies that need to be resolved in the training of professionals. To analyze the current state of preparation, a set of theoretical and empirical methods was used, with the help of which a number of problems that inhibit the process of ensuring the quality of training of a competitive specialist were identified. In order to study the current state of preparation, a set of questionnaires was developed and, within the framework of a pedagogical experiment, questionnaires were conducted among entrants, educators, graduates, pedagogical workers, heads of institutions of vocational (vocational-technical) education in the regions of Ukraine and employers, and the results of the questionnaire were analyzed.
The gender component in communication education in Ukraine: conflict communication problems
Authors: Kekalo Yulia
Published: March 2020

Communication is a universal phenomenon that is explored by many social sciences and humanities. In the structure of communication science has long been distinguished conflict communication. However, the gender aspect of the language conflict in Ukrainian studies is not solved, but highly relevant and in-demand today by scholars. In our work, we emphasize the need for a detailed study of the linguistic gender conflict within the framework of forming a communicative culture in Ukraine. The article analyzes the state standards of higher education in speciality 035 “Philology” for the first and second levels of higher education, where we pay attention to the formation of communicative competence. We argue that the gender identity of the speaker is not taken into account in the structure of communicative competence. This can be the result of conflicts between a man and a woman. Therefore, the author talks about the importance of gender competence within the communicative. The article also analyzes the program in the course of teaching conflict communication for postgraduate students, which allows characterizing gender conflict from different positions (national linguistic representation, spacetime parameters, social characteristics, age, etc.).
Practical philosophy of education: the ecological-discursive paradigm as the complex problem
Authors: Baluta Halyna
Published: March 2020

In the 21st century, more attention is drawn to the development of ecological thinking. Instead of explicating treatment of nature, a human being should take care of it. Such a caring attitude should become an educational universal, so it is to be transmitted as value. However, the ecological-discursive paradigm is still problematic in education. Therefore, the objective of the paper is to analyze it as a complex approach in philosophy of education. The paper considers environmental anthropology as the methodological basis of the ecological-discursive paradigm. Ecological culture is analyzed as ethnics of conservation. The paper emphasizes that ecological thinking cannot be developed without changing an epistemological model. Thus, instead of facts and competences, the person’s cognition should be based on values. The paper highlights the idea of diagnostic cognition, which is based on values. Its development in the process of education is the first step to the ecological-discursive paradigm.
Fostering students’ autonomy in learning English in nonlinguistic university
Authors: Pershukova Oksana , Nikolska Nina , Vasiukovych Oksana
Published: March 2020

The study aims to find out whether it is possible to foster students’ learner autonomy in the context of ESP language learning in non-linguistic universities by using a special approach. The experiment was carried out at National Aviation University in Ukraine with two groups of first-year students of electronics (experimental and control) in 2018-2019. Testings to determine students’ level of communicative competence in English and surveys to identify students’ level of learner autonomy development were conducted in September and May of the same year of education. The control group did not receive any special training, while in the experimental group were created special learning conditions. With the purpose to prepare students to accept responsibility for their learning, they were given the opportunities to choose educational materials; to set goals of their learning; to reflect the process and evaluate the results of learning, etc. Modern technologies were widely used as well as scaffolding (if necessary). According to the results of the experiment, it was stated that only a part of the most active students used the created conditions and gained experience in autonomous learning. The conclusion was made about creating such an environment. It is a challenge that is appropriate to realize to give an autonomous learning experience to aspiring students.
The problems of implementation of inclusive education in Ukraine: generalization the experience of empirical sociological researches experience
Authors: Hrabovets Iryna , Kalashnikova Liudmyla , Chernous Liudmyla
Published: March 2020

The article is devoted to current problems of the strategy of inclusion in the education system. The authors attempt to analyze documents regulating legal relations in the field of inclusive education, the accessibility of both educational and medical institutions, the readiness of the teaching community to work with children with special educational needs. The empirical basis formed by an array of empirical data collected by conducting a traditional analysis of documents, interviewing parents and teachers. The analysis result of conducted research allows us to conclude that informants are fully aware difficulties of inclusive education today. They are associated with the lack of architectural accessibility of the majority of school buildings, proper professional training of teachers, experience in communicating with children with various types and severity of diseases, and lack of readiness of society adequately to perceive the idea of integration.
Supervision as a model of inclusive education retraining and professional advancement of the school community
Authors: Bondar Kateryna , Shestopalova Olena
Published: March 2020

In this article, we describe the model of supervision in support of the Education Reform in Ukraine and the retraining of the school’s key stakeholders in an inclusion: the case of Kryvyi Rih. Empirical study has introduced a model of retraining through a socio-political and educational description of the current situation in Kryvyi Rih. That is why 124 key stakeholders from 20 schools with inclusive education were tested to plan the implementation model of supervision (teachers, tutors, staff, psychologists and parents from 7 districts of Kryvyi Rih were invited to participate). In this article, we present a different approach to supervisory interagency groups and understanding, with the focus on the model supervision retraining of inclusive education professionals. The supervision consists of four stages: case report, exchange, conceptualization, summary. For successful work, we propose in the article an adaptation of an unstructured interview by a specialist who describes the situation of training supervision. The analysis of the organizational, methodological and information retraining system, the implementation of the pilot project of supervisory groups for the psycho-educational support team in inclusive education allowed to offer the supervision program: I. Training of the team members to work with the goals of the individual child development plan: working with tools for preparation of the case; II. The main features of observing the lesson; III. Analysis of environmental factors; IV. Oversee team support.
Soft skills, their development and mastering among post graduate students
Authors: Volkova Nataliia , Zinukova Nataliia , Vlasenko Kateryna , Korobeinikova Tetiana
Published: March 2020

The article deals with the issues of the content, assessment of the current state and the main tendencies in the development of the so-called “soft skills”. At present soft skills are essential to have good job opportunities and university curriculum should be focused on developing and mastering them. The article analyses the results of the research of the soft skills development among post graduate students majoring in Professional Education of Alfred Nobel University, Dnipro. These data prove that postgraduate students realize the importance of mastering soft skills to make a successful career. Moreover, innovative teaching methods and techniques aimed at mastering soft skills are to be introduced into the educational process.
Professional training of future music art teachers for inclusive education: theoretical and technological aspects
Authors: Sysoieva Svetlana , Ovcharenko Natalia , Chebotarenko Olga
Published: March 2020

The article is devoted to the actual problem of contemporary art education ἦ#x201C; to improve the professional training of future music art teachers for children’s inclusive education. Its purpose is to present the results of theoretical understanding of the developmental and healing potential of music, to develop technological support in future music art teachers’ professional training for children’s inclusive education. According to the results of the study, the basic concept of the study was defined as: “professional training of future music art teachers for inclusive education”, which is seen as an educational process aimed at ensuring students’ readiness to provide a system of educational services to persons with special educational needs in their future professional activity, and it involves mastering their inclusively oriented musical and pedagogical knowledge, skills and personal qualities. To improve the professional training of future music art teachers for children’s inclusive learning, the findings of the latest research in the field of art and musicpedagogical theory concerning the harmonizing and music-therapeutic influence of music on the personality of a child in need of educational inclusion were used; criteria of musical works selection for children with psycho-physiological disabilities have been identified; there was developed and substantiated developmental and corrective technique of training singing that can be used in inclusive classes of different age, gender and cognitive abilities of children. Developmental and corrective technique of training singing includes innovative content of children’s teaching, comprising a specially selected vocal repertoire; lesson and extracurricular forms of training; specific teaching methods for students with special educational needs.
Enhancing interest in research activities in mathematics students in teacher training universities
Authors: Vlasenko Kateryna , Rovenska Olha , Lovianova Iryna , Kondratyeva Oksana , Achkan Vitaliy
Published: March 2020

The article looks into the issue of developing an interest in mathematics students’ research activities in the teacher training universities. The study is dedicated to the feasibility of involving the 5E Instructional Model to the organization of students’ scientific research during the workshop on the Approximation Theory and Fourier Series. The research considers the results of the survey among students who helped to evaluate their emotional state during the workshop. To collect the data we used the tool of express evaluation of positive and negative emotionality the Differential Emotion Scale. The article discusses the positive influence of the environment developed through the 5E Instructional Model on students’ emotional state and forming their interest in scientific research while organizing workshop classes. We have grounds to conclude that there is the efficiency of implementing workshops based on the 5E Instructional Model. The index reduction of students’ negative emotions encouraged their activity during the workshop and the improvement of interest in research activities.
Überlegungen zur kieferorthopädischen Therapie von Lippen-Kiefer-Gaumenspalten
Authors: Pichelmayer Margit
Published: March 2020

Bezüglich der kieferorthopädischen Behandlung von Lippen-, Kiefer- und Gaumenspalten gibt es viele verschiedenen Philosophien. Derzeit existiert kein international einheitliches Konzept. Die grundlegenden Überlegungen, die Behandlung dieser sehr häufigen angeborenen Fehlbildungen betreffend, sind jedoch sehr ähnlich, da sie sich automatisch aus den Defiziten von Weichteilen, Knochen und Zähnen ergeben. Ein nicht unwesentlicher Aspekt ist dabei der Umgang mit Abweichungen von der natürlichen Symmetrie, die in erster Linie bei einseitigen Spalten zu finden sind, die generell häufiger vorkommen als die doppelseitigen Fehlbildungen.
Clinical, Molecular, Functional, and Structural Characterization of
CYP17A1 Mutations in Brazilian Patients with 17-Hydroxylase
Deficiency
Authors: Coeli-Lacchini Fernanda Borchers , Mermejo Livia M. , Bodoni Aline Faccioli , Elias Lucila Leico Kagohara , Silva Jr Wilson Araújo , Antonini Sonir R. , Moreira Ayrton C. , de Castro Margaret
Published: March 2020

17-Hydroxylase-deficiency (17OHD) is a rare form of congenital adrenal
hyperplasia. The aim of the work was to study clinical, biochemical, and the
follow up of 17OHD patients and evaluate the function and structure of
CYP17A1 mutations. Brazilian patients (three 46, XX and four 46,
XY; 17±1.9 years) with combined 17-hydroxylase/17,20-lyase
deficiency were evaluated. CYP17A1 gene was sequenced. Functional
analysis was performed transfecting COS7 cells, which were exposed to
progesterone or 17α-hydroxypregnolone substrates. Hormones were
determined by RIA or LC-MS/MS. Three-dimensional structural modeling
was performed by Modeller software. All patients presented prepubertal
female external genitalia, primary amenorrhea, hypergonadotrophic
hypogonadism, hypokalemic hypertension, decreased cortisol, and increased
ACTH and corticosterone levels. Five patients presented previously described
mutations: p.W406R/p.W406R,
IVS2–2A>C/p.P428L, and p.P428L/p.P428L. Two
patients presented the compound heterozygous
p.G478S/p.I223Nfs*10 mutations, whose CYP17A1 activity and
the three dimensional structural modeling are originally studied in this
paper. CYP17A1 activity of p.G478S was 13 and 58% against
progesterone and 17-hydroxypregnenolone, respectively. The
p.I223Nfs*10 caused a truncated inactive protein. Three-dimensional
p.G478S structural modeling showed different internal hydrophobic
interaction with W313 and created an additional chain side contact with L476
residue. Due to the rarity of 17OHD, the long term follow up
(15.3±3.1 years) of our patients will help endocrinologists on the
management of patients with 17OHD. The mutation
p.G478S/pI223Nfs*10 led to severe 17OHD and impaired CYP17A1
structure and function. The integration of in silico and in vitro analysis
showed how the amino acid changes affected the CYP17A1 activity and
contributed to clarify the molecular interactions of CYP17A1.
Hearing Secret Harmonies: Balint and The Re-Imagining of Medicine
Authors: Elder Andrew
Published: March 2020

The author uses three poems – all by the same poet who was a respiratory physician – to describe the role the imagination in Balint groups, profoundly psychoanalytic in principle, in re-imagining medicine. He states that doctors emerge from medical school ‘one-eyed’ but can slowly move to restore ‘binocular vision’ through emotional insight and greater awareness of relationships gained through participation in a Balint group. He cites Enid Balint’s concept of ‘imaginative perception’ and describes a case which brings many of the themes of the talk together including unconscious communication and the nature of ‘time’ in the GP’s consulting room.
Ernährungsperiodisierung im Sport
Authors: Hottenrott Kuno , Hottenrott Laura
Published: March 2020

Sportler, die ihre Ernährung an das Training anpassen, können ihre Leistungsfähigkeit erhöhen und die Regeneration verbessern. Eine Ernährungsperiodisierung, wie das Intervallfasten oder der vorübergehende Verzicht auf eine energetisch ausreichende Nahrungsaufnahme, kann die Reizwirksamkeit des Trainings erhöhen. Davon profitieren insbesondere Sportler, die eine Veränderung der Körperzusammensetzung bewirken wollen.
Facile Construction of Troponoid Derivatives Incorporating Imidazolin-2-one Moieties
Authors: Yu Jing , Chen Xiaobei , Hu Yanwei , Wang Liang , Zhang Shilei , Liu Ye , Wu Bing , Li Haiyan
Published: March 2020

Troponoid derivatives incorporating imidazolin-2-one moieties were efficiently constructed via a cascade process, under simple thermal conditions, which features a novel nitrogen source, is catalyst- and oxidant-free, and has high atom- and step-economy.
Association between Maternal Serum Hormones along the Maternal–Fetal Hypothalamic–Pituitary–Adrenal Axis and Successful Vaginal Delivery Measured Prior to Labor Induction
Authors: Cawyer Chase R. , Lobashevksy Elena , Corley-Topham Glenda , Anderson Sarah , Owen John , Subramaniam Akila
Published: March 2020

Objective This study aimed to evaluate if maternal serum hormones along the maternal–fetal hypothalamic–pituitary–adrenal (HPA) axis, when drawn prior to labor induction, differed between women who delivered vaginally and those who underwent cesarean.

Study Design This was a prospective observational study at a single perinatal center performed from August 2017 to May 2018. Nulliparous women with uncomplicated singleton pregnancies ≥39 weeks had maternal serum collected prior to induction. Corticotrophin-releasing hormone (CRH) was measured by ELISA; dehydroepiandrosterone sulfate (DHEA-S), cortisol, estriol (E3) estradiol (E2), and progesterone (P4) were measured by chemiluminescent reaction. Mean analyte concentrations as well as three ratios (E2/P4, E3/P4, and E2/E3) were compared between women who had a vaginal versus cesarean delivery. Logistic regression was used to model the relationship between CRH and the odds of vaginal birth. We estimated that a sample size of 66 would have 90% power to detect a 25% difference in mean CRH levels assuming a vaginal:cesarean ratio of 2:1 with a baseline CRH concentration of 140 (standard deviation = 36) pg/mL.

Results Of the 88 women who had their serum analyzed, 27 (31%) underwent cesarean. Mean maternal serum CRH levels were similar between the vaginal delivery and cesarean groups (122.6 ± 95.2 vs. 112.3 ± 142.4, p = 0.73). Similarly, there were no significant differences in any other maternal serum analytes or ratios. Logistic regression showed a nonsignificant odds ratio for successful vaginal birth (p = 0.69) even when evaluating only the 16 women who had a cesarean for an arrest disorder (p = 0.08).

Conclusion In low-risk nulliparous women undergoing full-term labor induction, there were no differences noted in a broad array of other maternal-fetal HPA-axis hormones between women who had a vaginal or cesarean delivery.
HAUPTSTADTKONGRESS: Gemeinsam für Kompetenzen und Qualität
Authors: Dorner Carola
Published: March 2020

„Nur gemeinsam geht’s. Verbünde schaffen Vorteile“ ist der Titel einer Session beim Hauptstadtkongress im Juni 2020. Wir haben mit einem der Referenten, Dr. Jens Schick, über diese Vorteile gesprochen.
STATIONSAPOTHEKERIN: Detektivin am Patientenbett
Authors: Ehrhardt-Joswig Jana
Published: March 2020

Das neue Niedersächsische Krankenhausgesetz schreibt ab 2022 für jedes Krankenhaus einen Stationsapotheker vor. Das Klinikum Region Hannover ist seiner Zeit voraus und beschäftigt inzwischen an neun seiner zehn Standorte klinische Pharmazeuten. Davon profitieren alle: Patienten, Ärzte und Pflegekräfte.
VORBEHALTSAUFGABEN: Paradigmenwechsel in der Pflege
Authors: Heeser Alexandra
Published: March 2020

Das Pflegeberufegesetz schafft neue Handlungsspielräume und mehr Autonomie für die professionelle Pflege. Denn mit dem Gesetz wurde nicht nur die generalistische Ausbildung beschlossen, sondern es wurden auch Tätigkeiten festgeschrieben, die ausschließlich der Pflege vorbehalten sind.
25 JAHRE ÖVKT: Orientierung und Sicherheit
Authors: Thalmayr Maria
Published: March 2020

Immer schneller dreht sich das Karussell des Lebens. Unser Umfeld ist einem ständigen Wandel unterworfen, wird regelrecht geflutet von neuen Technologien. Umso wichtiger sind in diesem volatilen Außen Fixpunkte, die uns Sicherheit und Orientierung bieten bei der rasanten Fahrt. Eine dieser Konstanten ist seit einem Vierteljahrhundert der ÖVKT.
Structure-dependent electrochemical response characteristics of antimony tin oxide nanoparticle-based porous electrodes
Authors: Watanabe Yuichi , Kanazawa Kenji , Komazaki Yusuke , Nobeshima Taiki , Uemura Sei
Published: March 2020

Antimony tin oxide (ATO) nanoparticle-based porous electrodes have been investigated for use in fast-response electrochromic devices. However, despite their low resistivity, the electrochemical response characteristics of these electrodes are inferior to those of TiO2, which was attributed to the effect of small particle and pore size based on structural simulation. Therefore, we investigated the electrochemical response characteristics of ATO porous electrodes with different nanoparticle sizes, to clarify the effect of the porous electrode structure on response characteristics. The time required for charging an electric double layer (EDL) on the surface of a porous electrode increased as the particle size decreased. The ratios of the time constants of the EDL charging current between each porous electrode were larger than the ratios of the effective surface areas although the porous electrodes had almost the same resistivity. When the particle diameter was small (around 20 nm), the electrochromic reaction of dye modification on the porous electrode started 10 s after the application of a potential, because of the extremely low EDL formation rate. It was confirmed that the delay in EDL formation was induced by a lack of electrolyte ions inside the porous electrode. Therefore, to achieve ideal fast-response electrochemical reactions in low-resistivity nanoparticle-based porous electrodes, it is important to optimize the relationship between the electrode structure and the electrolyte ion concentration.