bluuebunny/crossref_metadata_2025 huggingface dataset:
POLÍTICA NACIONAL DE PAGAMENTO POR SERVIÇO AMBIENTAL
Authors: Santos Silas Silva , Gelfin Airton Roberto , Bertão Samira Monayari
Published: March 2023

O artigo tem por objetivo discutir as consequências jurídico-sociais ocasionadas pela promulgação da Lei nº 14.119/2021, denominada “Lei do Pagamento por Serviços Ambientais”, cujo artigo 9º, parágrafo único, prevê a possibilidade de contemplar, com o pagamento de serviços ambientais (PSA), os proprietários e possuidores de Áreas de Preservação Permanente (APPs), de Reserva Legal (ARLs) e de Áreas afetadas por Limitações Administrativas de caráter ambiental. As APPs e as ARLs, expressamente previstas no Código Florestal Brasileiro (Lei nº 12.651/2012) são espécies de limitações administrativas, destinadas a instrumentalizar os preceitos fundamentais do artigo 225 da Constituição Federal referente ao meio ambiente ecologicamente equilibrado. As limitações administrativas em geral são caracterizadas como obrigações de caráter geral, destinadas a assegurar um interesse público, impostas pelo Estado independentemente de indenizações ou compensações. Assim, o presente artigo contemplou uma análise dialética do artigo 9º, parágrafo único, da Lei nº 14.119/21, frente o Código Florestal e a Constituição Federal, no que se refere à tutela do meio ambiente. O resultado dessa análise evidenciou que a Lei 14.119/21, ao prever o PSA às APPs, ARLs e Áreas de Limitações Administrativas de caráter ambiental, desconsiderou que pela natureza jurídica, a preservar e recuperar o meio ambiental nessas áreas é uma obrigação inerente ao direito de propriedade, independente de indenização ou compensação. A solução encontrada parte de uma interpretação sistemática da Lei 14.119/21, da Lei 12.651/12 e da Constituição Federal de 1988, prevalecendo a certeza sobre a obrigação dos proprietários, possuidores e detentores em preservar e recuperar o meio ambiente junto as APPs, ARLs e Áreas de Limitações Administrativas de caráter ambiental independentemente da contemplação pelo PSA.

Palavras-chave: Pagamento por Serviços Ambientais. Área de Reserva Legal. Área de Preservação Permanente. Limitações Administrativas. Retrocesso Ambiental.
Digital Humanities Projects in Educational Process
Authors: Atamanchuk Viktoriia , Atamanchuk Petro
Published: March 2023

The purpose of the study is to outline the main directions and prospects of digital humanities development; to find out the main principles of the  scientific space transformation, caused by the implementation of digital humanities; to define the transdisciplinary ontology as digital humanities important tool.
Methodology of the article is based on implementation of principle of information systematicity and its further modeling in educational and scientific aspects. The information is being analysed for distinguishing its structural components and their semantic and functional coherence. According to the structural and semantic analysis of information, the modeling of information representation is performed. As the productive way of modeling is the transdisciplinary ontology, so principle of transdisciplinarity is one of the basical principle in the study.
Transdisciplinary ontology seems to be an important tool of digital humanities. Using ontology it is possible to perform educational information in structured form with all its components, organized in hierarchical construction, and their correlation depiction. Transdisciplinary ontology provides various forms of information graphical display, perception of which helps to understand essential causal factors, principles of information arrangement, its regularities
Recommendation for further transdisciplinary ontology application is based on the possible ontology extention by new elements adding according to the enrichment of educational material being learned.
The Future of Accessible Museums: Qualitative Analysis on Educational Practices
Authors: İşlek Didem
Published: March 2023

When the tourism policies of the countries were examined, it can be seen that that a very limited number of countries have knowledge and practices on accessible tourism. Museums, which are the most important building blocks of tourism, play an important role in both the creation of accessible tourism and the socialization of all individuals in society. Ensuring the accessibility of museums, which also makes important contributions to cultural sustainability, can be effective in shaping the museums of the future. In this context, the aim of this research was to evaluate the accessible museums of the future in terms of the views of teacher candidates trained in museums and lecturers taught and experienced in special education and to make recommendations. The sample group of the research consists of teacher candidates trained in museums (n=20) and lecturers taught and experienced in special education (n=22). The research data were carried out with the Phenomenology model which is one of the qualitative research methods. The data was collected through a semi-structured interview form. The data were analyzed by descriptive method. Research findings revealed that the interviewees think that accesible musems of the future have deficiency in time-space concept, the creation of virtual environments and digital infrastructures. In addition, they stated that there are deficiencies in accessing museums such as digital tools, architectural infrastructure, and virtual museums, and that these should be eliminated, and necessary stakeholders should be trained. Within the scope of the research, it is recommended that subject experts should provide training on accessibility to the Ministry of Tourism and Culture, officials and workers in museums, in archaeological sites and in historical places by taking the results of this study into consideration. Also, in order to obtain a permit for a new museum, ensuring the necessary mentioned conditions must become an important necessity. These will lead to a smooth accesibilty to museums for all stakeholers.
The Strategic Concept of Meritology in Learning
Authors: Callo Tatiana , Frantuzan Ludmila , Bâlici Veronica
Published: March 2023

This article addresses the issue of meritology as a strategic concept in the theory and practice of the learning process in school. The investigation of this field is generated by the need for the theoretical substantiation of the phenomenon in question, as well as by the deficient practice of capitalizing it in the process of assessing the student's learning activity. Based on constructivist ideals, correlative notions are analyzed, such as those of competition, effort, elite, knowledge, learning internalization, merit, and nano learning. Through analytical synthesis, the cardinal problems of meritology are recorded- the main question being that of clarification. In an innovative sense, the structure of the strategy associated with meritology is outlined, with the clarification necessary to use the concept of meritology as both strategically recorded and topical, shedding light on the specificity of the learning approach. Clarifying the pedagogical significance of meritology is the objective that generates the elaboration of the Strategy associated with meritology. The initial idea is to modernize the learning process by connecting to current social trends. The substantiation of the identity of meritology opens the perspective of the positive impact on the training of students through the internalization of learning and nano learning.
The Relationship between Neuropedagogic Approaches and the Formation of Skills of Primary School Students
Authors: Vasilieva Svetlana , Reipolska Olga , Podoliuk Svitlana , Sadova Iryna , Danyliak Ruslana , Lozenko Anna
Published: March 2023

The article analyzes the relationship between neuropedagogic approaches and the formation of skills of primary school students. Educational technology design potentially introduces another area of expertise and a new set of issues that require the integration of neuroscience, education, and technology concepts and insights. The educational process involves the implementation of a conceptual education system that begins with the child entering the first grade and ends with obtaining a qualification for a person. Therefore, studying involves an educational process, as a result of which certain competencies will be acquired. Thus, education will be effective for a person only when the degree of acquired competencies of the child at school, their value orientations and readiness for education are taken into account. So, in order to introduce effective education, we chose the direction of research on the study, analysis, justification of measures to increase the level of motivation of children to the educational process based on the conclusions of neuropedagogy. For the purpose of the study, the integration method of synthesis of the figurative structure was applied, for analysis on the theory and learning technology. Methods of synthesis in the pedagogical activity of the study can be traced on a number of educational technologies. The results of the study show that in general, neuropedagogic teaching technologies contribute to increasing motivation to learn among primary school children.
Social Entrepreneurship Education Promotion to the Socially Vulnerable Youth
Authors: Kravchenkova Halyna , Kalashnikova Alina , Soldatenko Iryna
Published: March 2023

The purpose of the present paper is to develop the key messages for social entrepreneurship education promotion among socially vulnerable youth. The scope of the research includes the communicative specificities of the vulnerable students with a special focus on orphans. The data for the research was obtained by conducting 12 expert interviews with educators and NGO members (2021-22, qualitative methodology). The results of the research showed that orphan students tend to hide their status and appear “average” in communication, though are more closed than their peers. It is discussed that communication with vulnerable students at HEI has to avoid treating them as special and motivate them to participate by messages of the personal empowerment and knowledge necessity to be autonomous and successful social subject. In conclusion, we propose the guidelines for educators’ communication with vulnerable youth and key messages for the inviting communication of the «Creative Spark. Making Good» social entrepreneurship educational project of the Anglia Ruskin University (Cambridge, UK) at V.N. Karazin Kharkiv National University.
Social Intelligence as a Factor of Socio-Psychological Adaptation of University Students with Special Educational Needs during Distance Learning due to the COVID-19
Authors: Starynska Olena , Spivak Liubov , Osmanova Alimie , Revutska Olena
Published: March 2023

The article is devoted to the research of social intelligence as a factor of socio-psychological adaptation of university students with special educational needs during distance learning. Study methods of social intelligence and socio-psychological adaptation are used. The respondents’ contingent of consisted of 78 students with special educational needs. The average level of social intelligence was empirically established in part students, which testifies to their ability to understand properly and the ability to behavior in almost half of life situations. Almost a quarter of students have a higher than average level of social intelligence and the same part is lower than average, which confirms their ability to understand and predict other people’s behavior in almost three quarters and one quarter of life situations, respectively. Students do not have high and low levels of social intelligence. Most students (almost two-thirds) have an average level of adaptability and mal-adaptability; instead, a minority (almost one third) is at a high level. Adaptability and mal-adaptability, respectively, indicate consistency and inconsistency between the needs of the individual and the requirements of the social environment. Students with a low level of adaptability and mal-adaptability were not found. The defined statistically significant relationship of social intelligence with adaptability (direct) and maladaptive (reverse) shows the influence of social intelligence on the effectiveness of socio-psychological adaptation of students. The results of the research proved that social intelligence is a factor of socio-psychological adaptation of students with special educational needs during distance learning.
Exploring the Relation between Teacher Candidates’ Emotional Intelligence and their Educational Practices: A Case Study in Greece
Authors: Tsoli Konstantina
Published: March 2023

Classroom management is a difficult task for teacher candidates and a significant barrier to being an effective teacher. The aim of this study was twofold: a) to examine the relation between student teachers’ emotional intelligence and their educational practices and b) whether emotional intelligence significantly predicted classroom management. The instruments used for data collection were TEIQue, a self-report questionnaire that measures trait emotional intelligence, and TEP-Q, a self-report questionnaire assessing three dimensions of classroom management: communication, organization, relationship. The sample of the study was comprised of third year undergraduate student teachers in the Department of Pedagogy and Primary Education at the National and Kapodistrian University of Athens, who had their first experience with teaching practice at primary schools. Descriptive statistics and correlational models showed that there is a statistically significant correlation between the factors. In fact, student teachers’ emotional intelligence predicted classroom management. Research results have pedagogical implications, while the impact of the research on practice and policy highlights the urge of social and emotional interventions during teachers’ both initial and ongoing education as well as the need to promote an educational design that embraces the goals of social and emotional learning at schools.
Reflexiones de un adolescente que ejerce violencia: los hombres frente al feminismo
Authors: Reyes Ibarra Vanessa Lilian , Figueroa Perea Juan Guillermo
Published: March 2023

A partir de un estudio de caso, este trabajo se centra en las posibilidades que tiene un adolescente varón de reflexionar, cuestionar y hacer rupturas sobre sus propios ejercicios de violencia y sobre las interpelaciones que ha vivido con las mujeres y el feminismo. A pesar de las consecuencias negativas que conlleva, la repetición de los rígidos roles de género y de los mandatos masculinos asociados a la violencia suelen mantenerse como parte de una identidad masculina marcada por la dominación. Sin embargo, la socialización de género, como proceso en continua construcción, abre la posibilidad de que los adolescentes varones cuestionen el rígido aprendizaje adquirido en la infancia. Se concluye que los adolescentes que ejercen la violencia pueden cuestionarse a sí mismos y romper con los mandatos previamente adquiridos asociados con la violencia.
Desmontando la masculinidad hegemónica: una (auto)etnografía del grupo Varones por el Cambio
Authors: Piñeyro Nelson Carlos
Published: March 2023

Este texto abordará, desde la etnografía digital y la autoetnografía, la experiencia del colectivo «Varones por el Cambio» - VC, espacio de hombres heterosexuales mayores de cuarenta años surgido en México en 2020, el cual solo ha interactuado de manera virtual usando plataformas como WhatsApp y programas para videoconferencias. Dicho grupo ha cuestionado patrones básicos de la masculinidad hegemónica desde la teoría de los micromachismos de Luis Bonino. Desde este espacio también se han dialogado cuestiones de violencia machista, la cosificación de las mujeres y la importancia de hablar sobre las emociones «negadas» a los varones (miedo, frustración, amor). Así, se verán las posibilidades y los límites de este tipo de procesos desarrollados completamente desde redes sociales, y vividos en primera persona del singular y del plural.
La masculinidad subalterna y racializada en las memorias de Lurgio Gavilán Sánchez
Authors: Muñoz-Díaz Javier
Published: March 2023

En este artículo, voy a analizar el sistema de género y la construcción de la masculinidad en la escritura autobiográfica de Lurgio Gavilán Sánchez. Ofrezco un análisis textual y hermenéutico de la segunda etapa de su escritura, que empieza con el «Epílogo» de la reedición de Memorias de un soldado desconocido de 2017 e incluye Carta al teniente Shogún de 2019. En esta segunda etapa, el lugar de enunciación de Gavilán Sánchez es una generación con coordenadas de región, clase social y género: los exsoldados ayacuchanos que participaron en el conflicto armado interno - CAI. En el rol de narratario o audiencia lectora implícita, esta generación de exsoldados coexiste con la figura del teniente Shogún, quien se convierte en modelo de masculinidad, paternidad y principio guía para el objetivo del memorialista de recuperar la dimensión familiar. Gavilán Sánchez emplea una retórica religiosa y un modo melodramático para narrar sus interacciones y las de miembros de su generación con este militar y otras figuras paternas. Propongo que la figura de Shogún, a quien el memorialista presenta como emblema de una práctica humanitaria y democratizadora, en realidad encarna el patriarcado colonial moderno y subordina la masculinidad racializada de Gavilán Sánchez. Asimismo, el modo melodramático impone el binarismo de género del patriarcado colonial moderno que despolitiza a las mujeres (el caso de la militante senderista Rosaura).
Aproximaciones teóricas para la comprensión de las masculinidades indígenas en México
Authors: Díaz Cervantes Rufino
Published: March 2023

En este trabajo se reflexiona sobre la perspectiva de género, la historización y la descolonización como parte de una propuesta teórico-metodológica, para entender a los ordenamientos de género que sostienen las masculinidades y los modelos de ser hombre, vinculados con la reproducción y la sobrevivencia indígena contemporánea en México. Es un primer esfuerzo de análisis reflexivo sobre cómo aproximarse a esas realidades etnizadas y generizadas, específicamente sobre las masculinidades y el ser hombre. Para ello se parte de discutir los aportes de algunos estudios de género de los hombres y de las masculinidades, que no constituyen una revisión exhaustiva y actualizada, sino apenas una aproximación al bagaje de conocimientos en crecimiento, para apoyar la propuesta metodológica con la que se busca entender los constreñimientos patriarcales, heterosexistas y colonizantes sobre el ser hombres y las masculinidades, que implica entender el ser mujeres, de pueblos indígenas. En este trabajo se plantea que se requieren relecturas de esas realidades a través de propuestas teórico-metodológicas que sean sensibles a esos contextos, para frenar las miradas homogenizantes del sujeto generizado indígena, en concreto del masculinizado desde ordenamientos de género occidentalizados.
Masculinidades queer y colitud: experiencias de varones chilenos en el contexto neoliberal
Authors: Azócar González Rodrigo
Published: March 2023

El modelo de sociedad neoliberal, de plena vigencia, pero profundamente cuestionado en Chile, pone en permanente tensión la configuración conservadora de una sociedad estructurada bajo una profunda raíz misógina y patriarcal, frente a la emergencia y posicionamiento de las diversidades sexo genéricas como sujetes políticos incidentes en un contexto social que se reorganiza. La visibilización de las experiencias de construcción de las masculinidades queer se expresa en los relatos de varones nacidos postdictadura y permite analizar las dimensiones y alcances del proyecto neoliberal en la configuración identitaria de les sujetes organizadas bajo una colitud que reconoce el valor de lo marginal y excluido bajo este contexto ideológico, y ayudará a comprender los contextos disidentes, las demandas comunitarias por el reconocimiento, la organización crítica de la diferencia y la profundización de los cuestionamientos producidos por los contextos de inequidad, desigualdad, dominación y subordinación que promueven los valores neoliberales.
Tradiciones etnográficas y antropologías en plural
Authors: Pacheco de Oliveira João
Published: March 2023

La obra de Malinowski sigue siendo un referente fundamental para la antropología. Su monografía más famosa, que se centró en los isleños de la Polinesia, llegó a hacer del trabajo de campo el método definitorio de una ciencia asumida como disciplina universitaria. Cien años después, sus recomendaciones metodológicas no pueden seguir siendo descontextualizadas; por el contrario, necesitan ser rexaminadas en términos de su propio contexto histórico. En trabajos posteriores, Malinowski llegó a establecer algunos procedimientos metodológicos radicalmente diferentes, que a su vez eran esenciales para la tradición etnográfica africanista. En otros contextos la antropología vino paralelamente a tomar formas bastante diferentes de la que asumió en Inglaterra en la primera mitad del siglo XX y se difundió en otras partes del mundo. En un esfuerzo porcomprender la antropología como un saber y una experiencia plurales, describo muy brevemente el surgimiento en Brasil de una tradición etnográfica muy distinta, que supera algunas de las limitaciones contenidas en los procedimientos recomendados por Malinowski y que viene a conectarse con líneas posteriores de investigación desarrolladas en las antropologíaslatinoamericanas.
Isolation of pathogenic Streptomyces spp. and determination of variability among the strains collected from potato
Authors: Saha A. K. , Naher N. , Haque M. E. , Rashid M. H. , Rahman M. M. E.​
Published: March 2023

A study was undertaken during 2008-2009, 2009-2010 and 2010-11 cropping seasons to isolate the variability(s) of Streptomyces spp. from lesion of common scab affected potato tubers in the Northern parts of Bangladesh (Rangpur division). There were twelve different pathogenic species isolated, which were different for colony colour, spore colour, spore ornamentation, spore chain morphology, other physiological characteristics (temperature, pH, melanin production, colour secret in oatmeal broth medium, carbon utilization and growth response in NaCl solution) and pathogenic reaction. Overall all collected isolates grow well within temperature range of 25°C to 30°C. In the present investigation, it was observed that isolates S2 and S11 could grow at pH 4.50. It was found that the growth of isolates increased as the pH value of medium increased. Considering all the characteristics of different isolates, isolate S5 agreed with the description of S. scabies having smooth, grey spores borne in spiral chains, producing melanin and utilizing eight recommended ISP diagnostic sugars with raffinose as a sole source of carbon. Rest eleven isolates could not identify.
Shelf Life Extension of Minimally Processed Jackfruit (Artocarpus heterophyllus Lam.) Portion
Authors: Gana K.R. , Mini C.
Published: March 2023

Background: In spite of vast potential and usefulness, jackfruit is still an underutilized fruit and more scientific research is needed to exploit it as a commercial fruit crop. Extension of shelf life of minimally processed jackfruit portion with quality could facilitate efficient marketing and transportation resulting in minimizing the post-harvest losses. Methods: Jackfruit portions of mature firm (varikka) and soft (koozha) fleshed types were pre-treated and subjected to seven packaging treatments viz., 150 gauge polypropylene with 5% ventilation, cling film wrapping with 15 µ LDPE film, shrink wrapping using 15µ polyolefin film, vacuum packaging in PP/LDPE laminated pouches, MAP in PP/LDPE laminated pouches with KMnO4, MAP in PP/LDPE laminated pouches with silica gel and an unwrapped sample and stored in refrigerated and ambient conditions. Result: Vacuum packaging of 200-250 g minimally processed jackfruit portions without spiny rind in laminated pouches of PP/LDPE after pre-treatment with 0.5% KMS and citric acid and storage under refrigeration is recommended as the best treatment for both types. Vacuum packaged firm fleshed portions had 94.54% marketability after 20.33 storage days and soft fleshed had 88.75% marketability after 15.33 days. Minimally processed jackfruit portion provides convenience in transportation and marketing of large and difficult to peel fruits to nuclear family.
Immunization Stress-Related Response (ISSR) from Covid-19 Vaccination First-Dose among Medical Clerkship Students in dr. Soebandi Hospital Jember
Authors: Supangat Supangat , Nurus Sakinah Elly , Ilham Tohari Achmad , Fahrudin Hidayat Muhammad Rijal , Nugraha Muhammad Yuda , Qodar Tegar Syaiful , Mulyono Bagus Wahyu
Published: March 2023

Vaccination is one of the recommended way to eradicate Covid-19 pandemic. Unfortunately, there are still many people who refuse to get vaccinated. One of the causes is anxiety about the side effects that occur after vaccination. With this misinformation about vaccines, public anxiety is getting higher, so that more and more people are hesitant to get vaccinated. The purpose of this study was to determine the level of anxiety related to vaccines in medical students who have more knowledge about vaccines than the general public society. The anxiety assessment method used was the Hamilton Rating Scale for Anxiety (HARS) questionnaire. There were 108 medical clerkship students in this study, consisting of 25 male respondents and 83 female respondents, aged between 21-27 years. Based on the HARS-score obtained, it showed that all respondents were in the low or minimal anxiety range. Aspects of anxiety predominately appeared in the pre-vaccination phase. The differences between men and women were influenced by hormonal fluctuations and conditions before vaccination, such as stress, workload, knowledge capacity, and information obtained related to vaccination.
Keywords: Anxiety, Covid-19, HARS-score, ISRR, Vaccines
Teachers’ role in online learning: Perspectives of prospective Indonesian EFL teachers
Authors: Christiani Natalia , Tungka Novalita Fransisca , Nainggolan Romauli
Published: March 2023

This study investigated how prospective English as a foreign language teachers perceived the role of their teachers in online learning and how those roles contributed to their experiences in a low-tech online learning context. This study surveyed 285 prospective teachers at seven universities across provinces with English Language Education programs in Indonesia (East Java, North Sumatera, Central Sulawesi, West Kalimantan, West Papua, East Nusa Tenggara and Bali) and interviewed 10 prospective teachers to provide a deeper understanding of their experiences. The results showed that the cognitive role is the most important teacher role perceived by prospective teachers in a low-tech online learning context. Three themes emerged from the results: the teacher’s cognitive sub-roles in providing learning assistance and recommendation, managerial sub-roles in leading, controlling and organizing the learning process and affective sub-roles in creating an enjoyable, relaxing learning environment and catching students’ attention in online learning. The discussion focuses on the different effects of the roles on creating a positive online learning environment for students. In conclusion, teaching skills related to the three roles of teachers in online learning must be taught explicitly in a teacher-training program through scenario-based learning activities. The implications of teacher-training programs are discussed further in this paper.
Association between homologous recombination deficiency and outcomes with platinum and platinum-free chemotherapy in patients with triple-negative breast cancer
Authors: Chen Yimeng , Wang Xue , Du Feng , Yue Jian , Si Yiran , Zhao Xiaochen , Cui Lina , Zhang Bei , Bei Ting , Xu Binghe , Yuan Peng
Published: March 2023

Objective: The choice of chemotherapeutic regimen for triple-negative breast cancer (TNBC) remains controversial. Homologous recombination deficiency (HRD) has attracted increasing attention in informing chemotherapy treatment. This study was aimed at investigating the feasibility of HRD as a clinically actionable biomarker for platinum-containing and platinum-free therapy. Methods: Chinese patients with TNBC who received chemotherapy between May 1, 2008 and March 31, 2020 were retrospectively analyzed with a customized 3D-HRD panel. HRD positivity was defined by an HRD score ≥ 30 or deleterious BRCA1/2 mutation. A total of 386 chemotherapy-treated patients with TNBC were screened from a surgical cohort (NCT01150513) and a metastatic cohort, and 189 patients with available clinical and tumor sequencing data were included. Results: In the entire cohort, 49.2% (93/189) of patients were identified as HRD positive (40 with deleterious BRCA1/2 mutations and 53 with BRCA1/2 intact with an HRD score of ≥ 30). In the first-line metastatic setting, platinum therapy was associated with longer median progression-free survival (mPFS) than platinum-free therapy [9.1 vs. 3.0 months; hazard ratio (HR), 0.43; 95% confidence interval 0.22–0.84; P = 0.01]. Among HRD-positive patients, the mPFS was significantly longer in those treated with platinum rather than platinum-free therapy (13.6 vs. 2.0 months; HR, 0.11; P = 0.001). Among patients administered a platinum-free regimen, HRD-negative patients showed a PFS significantly superior to that of HRD-positive patients (P = 0.02; treatment-biomarker P-interaction = 0.001). Similar results were observed in the BRCA1/2-intact subset. In the adjuvant setting, HRD-positive patients tended to benefit more from platinum chemotherapy than from platinum-free chemotherapy (P = 0.05, P-interaction = 0.02). Conclusions: HRD characterization may guide decision-making regarding the use of platinum treatment in patients with TNBC in both adjuvant and metastatic settings.
2022 Chinese expert consensus and guidelines on clinical management of toxicity in anti-CD19 chimeric antigen receptor T-cell therapy for B-cell non-Hodgkin lymphoma
Authors: Li Ping , Liu Yang , Liang Yun , Bo Jian , Gao Sujun , Hu Yongxian , Hu Yu , Huang He , Huang Xiaojun , Jing Hongmei , Ke Xiaoyan , Li Jianyong , Li Yuhua , Liu Qifa , Lu Peihua , Mei Heng , Niu Ting , Song Yongping , Song Yuqin , Su Liping , Tu Sanfang , Wang Jianxiang , Wu Depei , Wang Zhao , Xu Kailin , Ying Zhitao , Yang Qingming , Zhang Yajing , Shi Fengxia , Zhang Bin , Zhang Huilai , Zhang Xi , Zhao Mingfeng , Zhao Weili , Zhao Xiangyu , Huang Liang , Zhu Jun , Qian Wenbin , Han Weidong , Liang Aibin
Published: March 2023

Adoptive cellular immunotherapy with chimeric antigen receptor (CAR) T cells has emerged as a novel modality for treating relapsed and/or refractory B-cell non-Hodgkin lymphoma (B-NHL). With increasing approval of CAR T-cell products and advances in CAR T cell therapy, CAR T cells are expected to be used in a growing number of cases. However, CAR T-cell-associated toxicities can be severe or even fatal, thus compromising the survival benefit from this therapy. Standardizing and studying the clinical management of these toxicities are imperative. In contrast to other hematological malignancies, such as acute lymphoblastic leukemia and multiple myeloma, anti-CD19 CAR T-cell-associated toxicities in B-NHL have several distinctive features, most notably local cytokine-release syndrome (CRS). However, previously published guidelines have provided few specific recommendations for the grading and management of toxicities associated with CAR T-cell treatment for B-NHL. Consequently, we developed this consensus for the prevention, recognition, and management of these toxicities, on the basis of published literature regarding the management of anti-CD19 CAR T-cell-associated toxicities and the clinical experience of multiple Chinese institutions. This consensus refines a grading system and classification of CRS in B-NHL and corresponding measures for CRS management, and delineates comprehensive principles and exploratory recommendations for managing anti-CD19 CAR T-cell-associated toxicities in addition to CRS.
Cancer risk in relatives of BRCA1/2 pathogenic variant carriers in a large series of unselected patients with breast cancer
Authors: Liu Jiaming , Yao Lu , Sun Jie , Hu Li , Chen Jiuan , Zhang Juan , Xu Ye , Xie Yuntao
Published: March 2023

Objective: The spectrum and risk of cancer in relatives of BRCA1/2 pathogenic variant carriers in the Chinese population have not been established. Methods: A family history of cancer in 9903 unselected breast cancer patients was retrospectively analyzed. BRCA1/2 status was determined for all patients and relative risks (RRs) were calculated to evaluate cancer risk in relatives of the patients. Results: The incidences of breast cancer in female relatives of BRCA1 carriers, BRCA2 carriers, and non-carriers were 33.0%, 32.2%, and 7.7%, respectively. The corresponding incidences of ovarian cancer were 11.5%, 2.4%, and 0.5%, respectively. The incidences of pancreatic cancer in male relatives of BRCA1 carriers, BRCA2 carriers, and non-carriers were 1.4%, 2.7%, and 0.6%, respectively. The corresponding incidences of prostate cancer were 1.0%, 2.1%, and 0.4%, respectively. The risks of breast and ovarian cancers in female relatives of BRCA1 and BRCA2 carriers were significantly higher than female relatives of non-carriers (BRCA1: RR = 4.29, P < 0.001 and RR = 21.95, P < 0.001; BRCA2: RR = 4.19, P < 0.001 and RR = 4.65, P < 0.001, respectively). Additionally, higher risks of pancreatic and prostate cancers were noted in male relatives of BRCA2 carriers than non-carriers (RR = 4.34, P = 0.001 and RR = 4.86, P = 0.001, respectively). Conclusions: Female relatives of BRCA1 and BRCA2 carriers are at increased risk for breast and ovarian cancers, and male relatives of BRCA2 carriers are at increased risk for pancreatic and prostate cancers.
The Role of Surgical Debridement in the Treatment of Systemic Tetanus
Authors: Samson Trinity K. , Bono Kenneth T.
Published: March 2023

Case:

Tetanus is a potentially life-threatening infection of Clostridium tetani characterized by painful muscular spasms and hypertonia. Surgical debridement of infected tissue is intended to reduce the number of spores and limit the extent of the disease. We report a case of an unvaccinated 13-year-old adolescent boy who presented with systemic tetanus after stepping on a nail, and we describe the role that surgical debridement of infected tissue plays in optimizing outcomes.

Conclusion:

Orthopaedic surgeons must remain aware of the role of surgical debridement of wounds potentially infected with C. tetani because it is an important component of proper management.
Impact of Internal Malrotation of the Femur Followed by Derotational Osteotomy as Demonstrated by 3D Gait Analysis
Authors: Olson Brooke J. , Lenhart Rachel , Schmeling Gregory J. , Fritz Jessica M.
Published: March 2023

Case:

An 18-year-old man with 48° of internal malrotation of the femur after nailing underwent derotational osteotomy with gait dynamics and electromyography data collected preoperatively and postoperatively. Hip abduction and internal foot progression angles were significantly deviated from normal preoperatively compared with the contralateral side. At 10 months postoperatively, the hip was abducted and externally rotated throughout the entire gait cycle. His Trendelenburg gait had resolved, and he reported no residual functional concerns. Before corrective osteotomy, walking velocity was significantly slower with shorter stride lengths.

Conclusion:

Significant internal malrotation of the femur impairs hip abduction and foot progression angles as well as gluteus medius activation during ambulation. Derotational osteotomy considerably corrected these values.
A Squeaking Knee Is a Rare Complication of ACL Surgery
Authors: Frazer Philip M. , Talbot William
Published: March 2023

Case:

We report a rare case of a 36-year-old woman who underwent anterior cruciate ligament surgery (ACL), which was complicated by a squeaking knee postoperatively. The squeaking noise was likely due to migrating nonabsorbable suture engaging with the articular surface and created significant psychological stress but had no impact on the functional outcome of the patient. We eliminated the noise with an arthroscopic debridement of the suture that had migrated from the tibial tunnel.

Conclusion:

A squeaking knee after ACL surgery due to migrating suture is a rare complication that, in this case, improved with surgical debridement and diagnostic imaging seems to have a limited role.
An Off-Label Use of a Tensioned Proximal Humerus Plate for Tibiotalar Fusion
Authors: Aneja Arun , Sneed Chandler R. , Pectol Richard W. , Kavolus Matthew W. , Foster Jeffrey A. , Kinchelow Daria L.
Published: March 2023

Case:

A 70-year-old man presented with a left pilon fracture after a 10-foot fall from a ladder. The severe amount of comminution, joint destruction, and impaction from this injury eventually resulted in a tibiotalar fusion. Owing to multiple tibiotalar fusion plates not being long enough to span the extent of the fracture, a tensioned proximal humerus plate was used as an alternative.

Conclusion:

We do not endorse the off-label use of a tensioned proximal humerus plate for all tibiotalar fusions; however, we do believe that this is a useful technique in certain situations with large zones of distal tibial comminution.
Spliceosome component Usp39 contributes to hepatic lipid homeostasis through the regulation of lipophagy
Authors: Cui Donghai , Wang Zixiang , Dang Qianli , Wang Jing , Qin Junchao , Song Jianping , Zhai Xiangyu , Zhao Ling , Lu Gang , Liu Hongbin , Liu Runping , Shao Changshun , Zhang Xiyu , Liu Zhaojian
Published: March 2023

Regulation of alternative splicing (AS) enables a single transcript to yield multiple isoforms that increase transcriptome and proteome diversity. Here, we report that spliceosome component Usp39 plays a critical role in the regulation of hepatocyte lipid homeostasis. We demonstrate that Usp39 expression is downregulated in hepatic tissues of NAFLD and non-alcoholic steatohepatitis (NASH) subjects. Hepatocyte-specific Usp39 deletion leads to increased lipid accumulation, spontaneous steatosis and impaired autophagy. Combined analysis of RIP-seq and RNA-seq data reveals that Usp39 regulates AS of several autophagy-related genes. For example, deletion of Usp39 results in alternative 5’ splice site selection of exon 6 in Heat shock transcription factor 1 (Hsf1) and consequently reduced expression. Importantly, overexpression of Hsf1 restores attenuated lipid accumulation caused by Usp39 deficiency. Taken together, our findings indicate that Usp39-mediated AS is crucial for sustaining lipophagy and lipid homeostasis in the liver.
Preclinical immunogenicity and protective efficacy of a SARS-CoV-2 RBD based vaccine produced with the thermophilic filamentous fungal expression system Thermothelomyces heterothallica, C1.
Authors: Osterhaus Albert , Gonzalez-Hernandez Mariana , Kaiser Franziska , Steffen Imke , Ciurkiewicz Malgorzata , Amerongen Geert van , Tchelet Ronen , Emalfarb Mark , Saloheimo Markku , Wiebe Marilyn , Vitikainen Marika , Albulescu Irina , Bosch Berend-Jan , Baumgärtner Wolfgang , Haagmans Bart
Published: March 2023

The emergency use of vaccines has been the most efficient way to control the ongoing COVID-19 pandemic. However, the emergence of SARS-CoV-2 variants of concern has reduced the efficacy of currently used vaccines. The receptor-binding domain (RBD) of the SARS-CoV-2 spike protein is the main target for virus neutralizing (VN) antibodies. Here, we evaluated the immunogenicity and efficacy of a SARS-CoV-2 RBD vaccine candidate produced in the Thermothelomyces heterothallica (formerly Myceliophthora thermophila), C1 protein expression system, in a Syrian golden hamster (Mesocricetus auratus) infection model. One dose of 10 µg RBD vaccine based on SARS-CoV-2 Wuhan strain, coupled to a nanoparticle in combination with aluminum hydroxide as adjuvant, efficiently induced VN antibodies and reduced viral load and lung damage upon SARS-CoV-2 challenge infection. The VN antibodies, neutralized SARS-CoV-2 variants of concern D614G, Alpha, Beta and Gamma. Our results support the use of the Thermothelomyces heterothallica, C1 protein expression system to produce recombinant vaccines against SARS-CoV-2 and other virus infections, in order to help overcome limitations associated with the use of mammalian expression systems.
Assessment of suppliers through the resiliency and sustainability paradigms using a new MCDM model under interval type-2 fuzzy sets
Authors: Nemati Elyas , Mohamadzadeh Saeid
Published: March 2023

Today, improvement and development must occur in all parts of the supply chain, and supplier selection as the starting point of the chain must be considered one of the most critical parts of planning. In the current competitive and unstable environment, in selecting the best suppliers, common approaches such as resilience and sustainability can be helpful for organizations in terms of sustainability and competitive advantage. Therefore, designing a sustainable and resilient supply chain model and considering all these parameters can effectively provide products and services. Also, to consider real-world uncertainties, interval type-2 trapezoidal fuzzy sets (IT2TFSs) are used because these sets are more powerful than classical fuzzy sets and better reflect uncertainties. Then, a new version of the MULTIMOORA model called MULTIMOOSRA is extended. In this model, the importance of the criteria is specified using the best-worst method. The importance of experts is defined using a new version of the MABAC approach developed by the average concept. Then the rank of each supplier is determined by the developed MULTIMOOSRA method. Notably, the proposed approach is developed in the IT2TF environment to consider the uncertainties of real issues and the ambiguity caused by experts' opinions in the decision-making process. Eventually, a case study is solved utilizing the proposed approach, and the best supplier is determined under resilient and sustainable paradigms.
ETDA as a legacy soil chelatant; a comparative study to a more environmentally-sensitive alternative for metal removal by Pistia stratiotes L.
Authors: Lebrun Manhattan , Szakova Jirina , Drabek Ondrej , Tejnecky Vaclav , Hough Rupert Lloyd , Beesley Luke , Wang Hailong , Trakal Lukas
Published: March 2023

The accuracy of environmental risk assessment depends upon selecting appropriate matrices to extract the most risk-relevant portion of contaminant(s) from the soil. Here we applied the chelatants Na-EDTA and tartaric acid to extract a metal-contaminated soil. Pistia stratiotes was applied as an indicator plant to measure accumulation from the metal-laden bulk solutions generated, in a hydroponic experiment lasting 15 days. Speciation modelling was used to elucidate key geo-chemical mechanisms impacting matrix and metal-specific uptake revealed by experimental work. The highest concentrations of soil-borne metals were extracted from soil by Na-EDTA (7.4% for Cd), but their uptake and translocation to the plant were restricted due to the formation of stable metal complexes predominantly with DOC. Tartaric acid solubilized metals to a lesser extent (4.6% for Cd), but a higher proportion was plant-available due to its presence mainly in the form of bivalent metal cations. The water extraction showed the lowest metal extraction (e.g., 3.9% for Cd) but the metal species behaved similarly to those extracted by tartaric acid. This study demonstrates that not all extractions are equal and that metal-specific speciation will impact accurate risk assessment in soil (water)-plant systems. In the case of EDTA, a deleterious impact on DOC leaching is an obvious drawback. As such, further work should now determine soil, and not only metal, specific impacts of chelatants on the extraction of environmentally relevant portions of metal(loid)s.
Predictors of Frequent Emergency Department Visits among Hospitalized Cancer Patients: A Comparative Cohort Study Using Integrated Clinical and Administrative Data to Improve Care Delivery
Authors: Kurteva Siyana , Tamblyn Robyn , Meguerditchian Ari N.
Published: March 2023

Background
Frequent emergency department (FED) visits by cancer patients represent a significant burden to the health system. This study identified determinants of FED in recently hospitalized cancer patients, with a particular focus on opioid use.
Methods
A prospective cohort discharged from surgical/medical units of the McGill University Health Centre was assembled. The outcome was FED use (≥ 4 ED visits) within one year of discharge. Data retrieved from the universal health insurance system was analyzed using Cox Proportional Hazards (PH) model, adopting the Lunn-McNeil approach for competing risk of death.
Results
Of 1253 patients, 14.5% became FED users. FED use was associated with chemotherapy one-year pre-admission (adjusted hazard ratio (aHR) 2.60, 95% CI: 1.80–3.70), ≥1 ED visit in the previous year (aHR: 1.80, 95% CI 1.20–2.80), ≥15 pre-admission ambulatory visits (aHR 1.54, 95% CI 1.06–2.34), previous opioid and benzodiazepine use (aHR: 1.40, 95% CI: 1.10–1.90 and aHR: 1.70, 95% CI: 1.10–2.40), Charlson Comorbidity Index ≥ 3 (aHR: 2.0, 95% CI: 1.2–3.4), diabetes (aHR: 1.60, 95% CI: 1.10–2.20), heart disease (aHR: 1.50, 95% CI: 1.10–2.20) and lung cancer (aHR: 1.70, 95% CI: 1.10–2.40). Surgery (cardiac (aHR: 0.33, 95% CI: 0.16–0.66), gastrointestinal (aHR: 0.34, 95% CI: 0.14–0.82) and thoracic (aHR: 0.45, 95% CI: 0.30–0.67) led to a decreased risk of FED use.
Conclusions
Cancer patients with higher co-morbidity, frequent use of the healthcare system, and opioid use were at increased risk of FED use. High-risk patients should be flagged for preventive intervention.
Optical and Rogue type electrical soliton solutions of the (2+1) dimensional nonlinear Heisenberg ferromagnetic spin chains equation
Authors: Islam Shariful , Halder Bishnupada , Ali Ahmed Refaie
Published: March 2023

In this study, the uses of unified method for finding solutions of a nonlinear Schrodinger equation that describes the nonlinear spin dynamics of (2+1) dimensional Heisenberg ferromagnetic spin chains equation. We successfully construct solutions to these equations. For each of the derived solutions, we provide the parametric requirements for the existence of a valid soliton. In order to visualize some of the discovered solutions, we plot the 2D and 3D graphics. The results of this investigation, which have been presented, might be useful in elucidating the model's physical significance. These are a highly useful tool for studying how electrical solitons, which travel as voltage waves in nonlinear dispersive media, spread out, as well as for doing various physical calculations. The study's findings, which have been disclosed, might be useful in illuminating the models under consideration's physical significance and electrical field.