bluuebunny/crossref_metadata_2025 huggingface dataset:
Integrative evidence on the hybridization between Cenostigma microphyllum and C. pyramidale (Leguminosae) in the Caatinga dry forest
Authors: Aecyo P. , Costa L. , Jacobina U. P. , Harand W. , Leal I. R. , Souza G. , Pedrosa‐Harand A.
Published: December 2024

Interspecific hybridization plays an important role in plant evolution, contributing to taxonomic uncertainty through intermediate phenotypes or the emergence of novel traits. The characterization of hybridization is important to elucidate systematic relationships and its role in the diversification of lineages. The genus Cenostigma comprises neotropical legume trees with phylogenetic inconsistencies, and individuals showing intermediate morphology between sympatric species, suggesting natural hybridization.

We tested this hypothesis by investigating two endemic species from the Caatinga dry forest in northeast Brazil (C. microphyllum and C. pyramidale) using molecular markers (nuclear and plastid SSRs), geometric morphometrics, non‐targeted metabolomics, and ecological analyses.

We detected a high plastidial genetic structure among populations, not related to species boundaries but to their geographic distribution. The geometric morphometric analysis showed a clustering of pure individuals of both species with hybrids in an intermediate position, demonstrating the hybridization of these species in Caatinga. Nuclear DNA and metabolite diversity supported the separation of the two species into three clusters, with a subdivision of C. pyramidale in populations from the north (Pernambuco) and south (Bahia). Metabolomics revealed a fourth group formed mostly by hybrids. Later generation hybrids were detected as intermediate morphological forms, and gene flow was assumed as asymmetric among species and populations, being higher from C. pyramidale to C. microphyllum in populations from Bahia State. Ecological data indicated niche overlap.

Hence, interspecific gene flow occurs among Cenostigma tree species, contributing to the evolution of the dry forest. Given the karyotypic and genomic similarity among species, as well as molecular and ecological evidence, we infer that the hybrids are fertile, allowing introgression and contributing to systematic complexity in Cenostigma. Hybridization did not significantly increase chemodiversity in terms of novel compounds but differentiated hybrids from parental species. In summary, we highlight the importance of multiple evidence, particularly genetic, morphological, and metabolomic traits, in the identification of hybrids and its evolutionary impact in natural environments.
The distributional implications of pension benefit indexation
Authors: Andersen Torben M. , Jørgensen Cecilie Marie Løchte
Published: December 2024

Socio‐economic differences in longevity have fuelled a debate on whether pension systems have a regressive bias favouring groups with a high life expectancy. We show that the distributional implications of such pooling depend critically on the benefit profile across age/time, which in turn is determined by how benefits are indexed to prices and wages. Choosing an indexation scheme involves a choice between a low initial benefit with an increasing profile and a high initial benefit with a flat/decreasing profile, where the former benefits groups with a high life expectancy, and vice versa. We analyse how indexation affects the trade‐off between insurance and distribution when groups with different mortality are separated or pooled, and the optimal benefit profile under both standard preferences and temporal risk aversion with respect to the length of life.
Modelling a Dual-Objective Optimization Model for Cost Reduction and Disruption Risk Minimization in Automotive Supply Chains
Authors: Almadani Khalid , Bazilah Aziz Nur Arina
Published: December 2024

Dual-Objective Optimization model is vital in automotive supply chains (ASC) to emphasize multi-modal transportation under disruption scenarios at minimizing costs and disruption risks. In this context, the study evaluated the hypothetical and real-world data based on the deployment of the Non-dominated Sorting Genetic Algorithm II (NSGA-II) to understand the efficacy of incorporating multi-modal transportation to balance cost reduction and risk mitigation. The findings of Dual-Objective Optimization model revealed the model's superiority in identifying cost-effective transportation modes, offering a significant improvement over previous model. This research contributes to the mathematical modelling by providing a comprehensive framework for automotive supply chains, addressing operational efficiency and resilience against disruptions.
Comparative Analysis of Machine Learning Models to Predict Common Vulnerabilities and Exposure
Authors: Sheh Rahman Shaesta Khan , Adzhar Noraziah , Ahmad Zamani Nazri
Published: December 2024

Predicting Common Vulnerabilities and Exposures (CVE) is a challenging task due to the increasing complexity of cyberattacks and the vast amount of threat data available. Effective prediction models are crucial for enabling cybersecurity teams to respond quickly and prevent potential exploits. This study aims to provide a comparative analysis of machine learning techniques for CVE prediction to enhance proactive vulnerability management and strengthening cybersecurity practices. The supervised machine learning model which is Gaussian Naive Bayes and unsupervised machine learning models that utilize clustering algorithms which are K-means and DBSCAN were employed for the predictive modelling. The performance of these models was compared using performance metrics such as accuracy, precision, recall, and F1-score. Among these models, the Gaussian Naive Bayes achieved an accuracy rate of 99.79%, and outperformed the clustering-based machine learning models in effectively determining the class labels or results of the data it was trained on or tested against. The outcome of this study will provide a proof of concept to Cybersecurity Malaysia, offering insights into the CVE model.
La carga probatoria del asegurador en las objeciones y su incidencia en el cómputo de los intereses por mora en el pago de la indemnización derivada del contrato de seguro
Authors: Coronado Sabogal Diego Alejandro
Published: December 2024

En la Sentencia STC10662-2024 del 22 de agosto de 2024, la Corte Suprema de Justicia adiciona su jurisprudencia en torno al cómputo de los intereses moratorios en el contrato de seguro, la valoración judicial del cumplimiento de las cargas probatorias de las partes y el valor presunto en los seguros reales. La Corte determinó que, dependiendo de las circunstancias del caso, los intereses moratorios se causarán desde el mes siguiente a la fecha en que el asegurado acredite la ocurrencia y cuantía del siniestro, o desde la ejecutoria de la sentencia que ordena el pago de la indemnización. La Corte enfatizó que el juez debe examinar con igual rigor el cumplimiento de las cargas probatorias tanto del asegurado como de la aseguradora, según lo establecido en el artículo 1077 del Código de Comercio. Particularmente, destacó que en los seguros reales bajo la modalidad de valor presunto, ante una pérdida total o hurto, el asegurado solo debe probar la ocurrencia del siniestro, no la cuantía de la pérdida. En el caso concreto, la Corte revocó la sentencia impugnada y concedió el amparo solicitado, al considerar que el juez de segunda instancia incurrió en una vía de hecho por indebida valoración probatoria al no examinar adecuadamente el cumplimiento de la carga probatoria de la aseguradora en su objeción a la reclamación.
An Experimental Investigation on Combustion and Emissions of a Hydrogen Enriched Ammonia–Diesel Dual Fuel Engine at a Medium Load Condition
Authors: Guo Hongsheng , Liko Brian , Stevenson David , Austin Kevin
Published: December 2024

As a carbon-free hydrogen carrier, ammonia is easy to store, handle, and distribute compared to hydrogen itself. Switching from diesel to green ammonia in heavy-duty compression ignition engines dominating the power generation of freight transportation industry has the potential to reduce greenhouse gas (GHG) emissions. However, due to the low flame speed and presence of fuel-bound nitrogen, ammonia combustion may result in certain unburned ammonia slip and nitrous oxide (N2O) emissions, which offsets its zero-carbon advantage in applications. In this paper, an investigation on the influence of hydrogen blending on ammonia slip and emissions of nitrogen oxide (NO), N2O, and GHG in a heavy-duty ammonia–diesel dual fuel engine is experimentally conducted at a medium engine load, various hydrogen blending ratios, and different gaseous fuel energy fractions. The results reveal that hydrogen blending does help significantly reduce ammonia slip. However, hydrogen blending does not help reduce N2O emissions at relatively lower gaseous fuel energy fractions that result in lower equivalence ratio for hydrogen/ammonia mixture but does help reduce N2O emissions at relatively larger gaseous fuel energy fractions. As a result, hydrogen blending does not help reduce GHG emissions at relatively lower gaseous fuel energy fractions, but does help at higher gaseous fuel energy fractions. Blending of a small amount of hydrogen significantly improves engine efficiency, but the effect of further increasing hydrogen blending ratio on engine efficiency is insignificant. A side effect of hydrogen blending is that it increases NO emissions since it not only increases combustion temperature but also promotes the NO formation via fuel route during ammonia combustion.
TASER dart causes penetrating intracranial injury
Authors: Shetty Arnav , Solis Waldo Gerard , Brooks Michael , Abraszko Renata
Published: December 2024

Although conducted electrical weapons (CEWs) such as the Thomas A. Swift’s Electric Rifle (TASER) provide a less lethal means for subduing persons than firearms or stun guns, they have the potential to cause adverse injury. This report discusses the intracranial penetration of a TASER dart.

We present a case of a woman in her early 40s who was subdued by New South Wales Police with a TASER. The dart impacted her skull resulting in a tonic-clonic seizure. Examination and imaging in the emergency department revealed intracranial penetration to a depth of 4 mm. An emergency craniotomy was performed. She had no neurological deficits and subsequently discharged herself from the hospital.

This case demonstrates that penetrating head injury causing brain injury with subsequent seizures is possible with TASER use, contrary to common belief. While they are not intended to penetrate the skull, traumatic brain injury requiring neurosurgical intervention should be considered if CEWs such as TASER are pointed at the human head, especially at shorter ranges. This report demonstrates that utmost caution should be ensured with their use. We outline the weapon’s mechanism, review the literature and discuss the physical properties of the collision in order to investigate the likelihood of intracranial injury.
Improving early initiation and exclusive breastfeeding practice through PDSA framework: the experience at a private hospital in Tanzania
Authors: Osman Rukhsar , Katigula Idda , Charles Richard , Ayubu Agnes , Mkakilwa Paula , Abdallah Yaser , Noorani Mariam
Published: December 2024

Introduction

Optimal breastfeeding can save the lives of over 800 000 children annually. WHO recommends that all babies initiate breastfeeding within first hour of life, exclusively breastfeed for the first 6 months and continue breastfeeding up to 2 years and beyond. In Tanzania, 70% of babies initiate breastfeeding within first hour and only 64% of infants under 6 months are exclusively breastfed.

Objective

Improve rate of early initiation and exclusive breastfeeding from birth to hospital discharge, with the aim of achieving 80% as per Baby Friendly Hospital Initiative standard through implementing quality improvement project.

Methods

A quality improvement project was conducted using a Plan-Do-Study-Act (PDSA) framework. Baseline rates of early initiation and exclusive breastfeeding were determined. Sequential strategies were implemented including drafting and implementing hospital policy on breastfeeding and use of formula milk, staff training on lactation management and antenatal education of pregnant women using breastfeeding videos. These were followed by immediate skin-to-skin contact after caesarean birth and modification of newborn feeding charts. Subsequently, daily lactation rounds were implemented, and monthly antenatal classes were conducted for women identified as high risk for breastfeeding challenges. Progress was monitored through monthly audits.

Results

After three PDSA cycles, early breastfeeding initiation improved from 22% to 84% and exclusive breastfeeding rate increased from 45% to 90%.

Conclusion

Early and exclusive breastfeeding rates in hospital can be improved by multidimensional approach including policies, staff training, antenatal education, interdepartmental involvement and having dedicated staff to support lactation.
Role of BPO4 flux in BaBPO5 crystal growth characterized through high-temperature Raman spectroscopy
Authors: Zhang Ji , Wu Yong , Zhang De-Ming
Published: December 2024

In this study, we explored the growth of incongruently melting crystals in a starting solution with flux to better understand the role of flux in crystal growth mechanisms. We recorded the spectrum of BaBPO5 crystals across a 200–1400 cm−1 range for detailed Raman spectroscopic analysis. The observed Raman bands corresponded to the vibrations of PO4 and BO4 units. These units link with B–O–P bonds via common corners to form PBO7 groups that serve as basic structural units of the crystal. Notably, these PBO7 structures remain stable at high temperatures up to the crystal melting point, at which the isolated PO4 groups predominantly exist in the melt, as revealed by high-temperature Raman spectroscopy. Further investigations into the Raman spectra of the starting solution enriched with BPO4 self-flux indicate that PBO7 groups are crucial for crystal growth. The addition of PBO4 flux aids in the formation of these PBO7 units. This research paves the way for expanding our understanding to other systems, which will help elucidate the mechanisms behind crystal growth.
Analytical study about effects of lubrication on dynamic characteristics of defect-ball ceramic bearing
Authors: Wang Zinan , Wang Qian , Zhou Peng , Zhang Shiying , Lv Qingye
Published: December 2024

Due to the self-lubrication and high stiffness, the ceramic bearings are widely applied in mechanical system. However, under some complex working conditions, the happening of defection and uncertain lubrication on the ball's surface is complex. Insufficient oil may increase friction and shorten defect bearing's life. In the paper, the self-lubrication characteristic of defect-ball ceramic bearing is considered to investigate the lubrication performance. Firstly, a novel lubrication model of ceramic bearing is established through Hamrock-Dowson theory. Then, the Newton–Raphson method is employed to analyze the dynamic of defect bearing. Finally, the effect of oil film thickness on the dynamic characteristic of ball-defect ceramic bearing is explored systematically. A vibrometer and the temperature sensors are used in the experiment to validated the accuracy of model. The vibration of defect-ball bearing is highly accord with the experiment, with an error less than 5%. The results indicate that enlarging the volume fraction of oil appropriately improve the effect of lubrication on dynamic of defect bearing. It will decrease the vibration of defect-ball bearing in high-speed condition. Research results have a significance guidance about the oil supply amount on the defect-ball ceramic bearing under a certain condition.
Contemporary Software Modernization: Strategies, Driving Forces, and Research Opportunities
Authors: Assunção Wesley K. G. , Marchezan Luciano , Arkoh Lawrence , Egyed Alexander , Ramler Rudolf
Published: December 2024

Software modernization is a common activity in software engineering, since technologies advance, requirements change, and business models evolve. Differently from conventional software evolution (e.g., adding new features, enhancing performance, or adapting to new requirements), software modernization involves re-engineering entire legacy systems (e.g., changing the technology stack, migrating to a new architecture style, or programming paradigms). Given the pervasive nature of software today, modernizing legacy systems is paramount to provide customers with competitive and innovative products and services, while keeping companies profitable. Despite the prevalent discussion of software modernization in gray literature, and the many papers in the literature, there is no work presenting a “big picture” of contemporary software modernization, describing challenges, and providing a well-defined research agenda. The goal of this work is to describe the state of the art in software modernization in the past 10 years. We collect the state of the art by performing a rapid review (searching five digital libraries), identifying potential 3,460 studies, leading to a final set of 127. We analyzed these studies to understand which strategies are employed, the driving forces that lead organizations to modernize their systems, and the challenges that need to be addressed. The results show that studies in the last 10 years have explored eight strategies for modernizing legacy systems, namely cloudification, architecture redesign, moving to a new programming language, targeting reuse optimization, software modernization for new hardware integration, practices to leverage automation, database modernization, and digital transformation. Modernization is triggered by 14 driving forces, with the most common ones being reducing operational costs, improving performance and scalability, and reducing complexity. In addition, based on the analysis of existing literature, we present a detailed discussion of research opportunities in this field. The main challenges are providing tooling support, followed by defining a modernization process and considering better evaluation metrics. The main contribution of our work is to equip practitioners and researchers with knowledge of the current state of contemporary software modernization so that they are aware of practices and challenges to be addressed when deciding to modernize legacy systems.
Students Report from ACM MMsys 2023
Authors: Rossi Silvia
Published: December 2024

The 14th ACM Multimedia Systems Conference (with the associated workshops: NOSSDAV 2023, MMVE 2023, and the first edition of GMSys 2023) took place from 7th - 10th June 2023 in Vancouver, Canada. The MMSys conference brings together researchers in multimedia systems to showcase and exchange their cutting-edge research findings. Once again, there were technical talks spanning various multimedia domains and inspiring keynote presentations. Participants had also the opportunity to further interact with colleagues while enjoying the sunset with a 360° view of Vancouver on the Lookout tower or during a dinner in the core of the rainforest. Additionally, this year's event included a special session dedicated to the memory of Dr. Kuan-Ta Chen, to honor his invaluable contributions to the multimedia community and to inspire the future generation of researches.

To encourage junior researchers to participate on-site, SIGMM has sponsored a group of students with Student Travel Grant Awards. For many of them, this was their first time presenting at an international conference, and it was a wonderful experience. In this article, the recipients of the travel grants share their experiences at MMSys 2023.
Video Interviews at ACM Multimedia 2022
Authors: Keighrey Conor , Rossi Silvia
Published: December 2024

This column showcases a series of video interviews shooted at ACM Multimedia 2022.

Social media editors in chief (i.e., Silvia Rossi and Conor Keighrey) of the records interviewed the authors behind some of the most intriguing and compelling demos and artistic interactive artworks. Silvia and Conor have started this initiative and will continue, when possible, at conferences supported by SIGMM.
MPEG Column: 143rd MPEG Meeting in Geneva, Switzerland
Authors: Timmerer Christian
Published: December 2024

The 143rd MPEG meeting took place in person in Geneva, Switzerland. The official press release can be accessed here and includes the following details:

•MPEG finalizes the Carriage of Uncompressed Video and Images in ISOBMFF

•MPEG reaches the First Milestone for two ISOBMFF Enhancements

•MPEG ratifies Third Editions of VVC and VSEI

•MPEG reaches the First Milestone of AVC (11th Edition) and HEVC Amendment

•MPEG Genomic Coding extended to support Joint Structured Storage and Transport of Sequencing Data, Annotation Data, and Metadata

•MPEG completes Reference Software and Conformance for Geometry-based Point Cloud Compression

We have adjusted the press release to suit the audience of ACM SIGMM and emphasized research on video technologies. This edition of the MPEG column centers around ISOBMFF and video codecs. As always, the column will conclude with an update on MPEG-DASH.
Report from CBMI 2023
Authors: Chetouani Aladine
Published: December 2024

The 20th International Conference on Content-based Multimedia Indexing (CBMI) was held exclusively as an in-person event in Orleans, France, on September 20-22, 2023. The conference was organized by the University of Orleans and received support from SIGMM. This edition marked a significant milestone as it was the first fully physical conference following the pandemic, providing a welcome opportunity for face-to-face interactions. The event drew a diverse and international audience, with participation from between 70 and 80 attendees representing 18 countries (12 Europeans, 4 Asians, 1 American and 1 African). Additionally, the conference included a European meeting (CHIST-ERA XAIface project) associated with the main event, which brought together approximately 15 individuals. Furthermore, several engineering students from the University of Orleans were invited to participate, allowing them to gain insights into cutting-edge multimedia research and exchange knowledge and ideas.
MPEG Column: 144th MPEG Meeting in Hannover, Germany
Authors: Timmerer Christian
Published: December 2024

The 144th MPEG meeting was held in Hannover, Germany! For those interested, the press release is available with all the details. It's great to see progress being made in person (cf. also the group pictures below). The main outcome of this meeting is as follows:

•MPEG issues Call for Learning-Based Video Codecs for Study of Quality Assessment

•MPEG evaluates Call for Proposals on Feature Compression for Video Coding for Machines

•MPEG progresses ISOBMFF-related Standards for the Carriage of Network Abstraction Layer Video Data

•MPEG enhances the Support of Energy-Efficient Media Consumption

•MPEG ratifies the Support of Temporal Scalability for Geometry-based Point Cloud Compression

•MPEG reaches the First Milestone for the Interchange of 3D Graphics Formats

•MPEG announces Completion of Coding of Genomic Annotations

We have modified the press release to cater to the readers of ACM SIGMM Records and highlighted research on video technologies. This edition of the MPEG column focuses on MPEG Systems-related standards and visual quality assessment. As usual, the column will end with an update on MPEG-DASH.
Effect of Different Binders on the Power Characteristics for Carbon Fluorides in Lithium Primary Batteries
Authors: Liu Wen , Ma Sen , Yan Tingfang , Wan Bingxin , Ma Shangde , Li Yong , Pei Haijuan , Guo Rui , Wu Chao , Xie Jingying
Published: December 2024

This study demonstrates the effect of different binders on the power characteristics of carbon fluorides (CF
x
) cathode material for power-type lithium primary batteries. Specifically, polymer binders, such as polyacrylic latex (LA133), poly(vinylidene fluoride) (PVDF) and carboxymethyl cellulose (CMC) are utilized in the preparation of CF
x
composite electrodes. The selection of binders significantly influences the rate performance of Li/CF
x
batteries. Among the binders tested, the LA133 binder notably reduces the electrode resistance and interface impedance of the batteries compared to PVDF and CMC, resulting in outstanding rate performance at 1 C. Additionally, this study discusses the impact of binder chemistry on the overall performance of the batteries.
Successful Bailout of Catheter‐Induced Dissection in Acute Myocardial Infarction Resulting From a Nondominant Right Coronary Artery Occlusion
Authors: Abe Hiroshi , Aikawa Tadao , Yokoyama Ken , Minamino Tohru
Published: December 2024

A 48‐year‐old male with a history of hyperlipidemia presented to the emergency department with chest pain. Electrocardiographic abnormalities indicated an acute coronary syndrome. Urgent coronary angiography revealed nondominant right coronary artery (RCA) occlusion. During primary percutaneous coronary intervention (PCI), a 0.014‐inch floppy guidewire could not be easily advanced into the middle RCA due to poor backup support from the guiding catheter and the patient’s breathing. The pressure was monitored several times after reinserting the guiding catheter. Nevertheless, the guidewire was inadvertently inserted into the false lumen from the ostium, leading to subsequent dissection during contrast injection. Intravascular ultrasound (IVUS) imaging confirmed dissection from the ostium to the middle RCA and passage of the guidewire into the false lumen. An additional guidewire was successfully inserted into the true lumen of the RCA using real‐time IVUS‐guided wiring. We demonstrated successful bailout stenting for catheter‐induced dissection of the nondominant small RCA. Our case highlights the risk of coronary artery dissection associated with guiding catheter use, especially in a nondominant small RCA, and the importance of optimal guiding catheter selection for primary PCI. The real‐time IVUS‐guided wiring technique can be applied to a single 6‐Fr guiding catheter and is useful for quickly inserting a guidewire into the true lumen.
Machine Learning and Mendelian Randomization Reveal Molecular Mechanisms and Causal Relationships of Immune‐Related Biomarkers in Periodontitis
Authors: Li Yuan , Zhang Bolun , Li Dengke , Zhang Yu , Xue Yang , Hu Kaijin
Published: December 2024

This study aimed to investigate the molecular mechanisms of periodontitis and identify key immune‐related biomarkers using machine learning and Mendelian randomization (MR). Differentially expressed gene (DEG) analysis was performed on periodontitis datasets GSE16134 and GSE10334 from the Gene Expression Omnibus (GEO) database, followed by weighted gene co‐expression network analysis (WGCNA) to identify relevant gene modules. Various machine learning algorithms were utilized to construct predictive models, highlighting core genes, while MR assessed the causal relationships between these genes and periodontitis. Additionally, immune infiltration analysis and single‐cell sequencing were employed to explore the roles of key genes in immunity and their expression across different cell types. The integration of machine learning, MR, and single‐cell sequencing represents a novel approach that significantly enhances our understanding of the immune dynamics and gene interactions in periodontitis. The study identified 682 significant DEGs, with WGCNA revealing seven gene modules associated with periodontitis and 471 core candidate genes. Among the 113 machine learning algorithms tested, XGBoost was the most effective in identifying periodontitis samples, leading to the selection of 19 core genes. MR confirmed significant causal relationships between CD93, CD69, and CXCL6 and periodontitis. Further analysis showed that these genes were correlated with various immune cells and exhibited specific expression patterns in periodontitis tissues. The findings suggest that CD93, CD69, and CXCL6 are closely related to the progression of periodontitis, with MR confirming their causal links to the disease. These genes have potential applications in the diagnosis and treatment of periodontitis, offering new insights into the disease’s molecular mechanisms and providing valuable resources for precision medicine approaches in periodontitis management. Limitations of this study include the demographic and sample size constraints of the datasets, which may impact the generalizability of the findings. Future research is needed to validate these biomarkers in larger, diverse cohorts and to investigate their functional roles in the pathogenesis of periodontitis.
Table S6 from Combined Autophagy Inhibition and Dendritic Cell Recruitment Induces Antitumor Immunity and Enhances Immune Checkpoint Blockade Sensitivity in Pancreatic Cancer
Authors: Oyama Koki , Nakata Kohei , Tsutsumi Chikanori , Hayashi Masataka , Zhang Bo , Mochida Yuki , Shinkawa Tomohiko , Hirotaka Kento , Zhong Pingshan , Date Satomi , Luo Haizhen , Kubo Akihiro , Higashijima Nobuhiro , Yamada Yutaka , Abe Toshiya , Ideno Noboru , Koikawa Kazuhiro , Iwamoto Chika , Ikenaga Naoki , Ohuchida Kenoki , Onishi Hideya , Morisaki Takashi , Kuba Keiji , Oda Yoshinao , Nakamura Masafumi
Published: December 2024

Top 30 DEGs for four DC clusters identified from scRNA-seq of CD45+ immune cells in KPC1 shNC / shATG7 syngeneic PDAC tumors
Supplementary Figures 1-8 from Inhibition of JNK Signaling Overcomes Cancer-Associated Fibroblast-Mediated Immunosuppression and Enhances the Efficacy of Immunotherapy in Bladder Cancer
Authors: Cui Chengying , Zhang Haojie , Yang Congcong , Yin Mingwei , Teng Xinkun , Yang Miaomiao , Kong Dejie , Zhang Jinzhi , Peng Weidong , Chu Zhimin , Wang Jingjing , Sun Yating , Kang Liping , Lyu Bin , Gao Qian , Wu Mingqing , Wang Yongqiang , Li Yang
Published: December 2024

Supplementary Figures 1-8
Supplementary Table S5 from Large-Scale Comparative Analysis of Canine and Human Osteosarcomas Uncovers Conserved Clinically Relevant Tumor Microenvironment Subtypes
Authors: Patkar Sushant , Mannheimer Joshua , Harmon Stephanie A. , Ramirez Christina J. , Mazcko Christina N. , Choyke Peter L. , Brown Gregory Thomas , Turkbey Baris , LeBlanc Amy K. , Beck Jessica A.
Published: December 2024

HALO-AI (v3.6) Osteoid quantification (%Positive Osteoid area) outputs for each case that passed quality review.
Supplementary Table S7 from Spatial Dynamics of T- and B-Cell Responses Predicts Clinical Outcome of Resectable and Unresectable Hepatocellular Carcinoma
Authors: Kurebayashi Yutaka , Sugimoto Katsutoshi , Tsujikawa Hanako , Matsuda Kosuke , Nomura Rui , Ueno Akihisa , Masugi Yohei , Yamazaki Ken , Effendi Kathryn , Takeuchi Hirohito , Itoi Takao , Hasegawa Yasushi , Abe Yuta , Kitago Minoru , Ojima Hidenori , Sakamoto Michiie
Published: December 2024

Table S7. Antibodies used in this study
Table S2 from Anlotinib plus TQB2450, a PD-L1 Antibody, in Patients with Advanced Alveolar Soft Part Sarcoma: A Single-Arm, Phase II Trial
Authors: Tan Zhichao , Wu Yan , Fan Zhengfu , Gao Tian , Guo Wei , Bai Chujie , Xue Ruifeng , Li Shu , Zhang Lu , Wang Xinyu , Jia Ling , Liu Jiayong
Published: December 2024

TLS area and count in ASPS patients
Supplementary Table S1 from SWOG/NCI Phase II Dual Anti–CTLA-4/PD-1 Blockade in Rare Tumors: Nonepithelial Ovarian Cancer
Authors: Chae Young Kwang , Othus Megan , Patel Sandip Pravin , Wilkinson Kelly J. , Whitman-Purves Emily M. , Lea Jayanthi , Schallenkamp John M. , Adra Nabil , Appleman Leonard J. , Alden Mitchell , Thomes Pepin Jessica , Ellerton John A. , Poklepovic Andrew , Walter Adam , Rampurwala Murtuza M. , Robinson William R. , Kim Hye Sung , Chung Liam Il-Young , McLeod Christine M. , Lopez Gabby , Chen Helen X. , Sharon Elad , Streicher Howard , Ryan Christopher W. , Blanke Charles D. , Kurzrock Razelle
Published: December 2024

Supplemental Table 1. Patient level data for 17 evaluable patients with non-epithelial cancers of the ovary treated on the DART immunotherapy protocol (nivolumab plus ipilimumab).
Data from SWOG/NCI Phase II Dual Anti–CTLA-4/PD-1 Blockade in Rare Tumors: Nonepithelial Ovarian Cancer
Authors: Chae Young Kwang , Othus Megan , Patel Sandip Pravin , Wilkinson Kelly J. , Whitman-Purves Emily M. , Lea Jayanthi , Schallenkamp John M. , Adra Nabil , Appleman Leonard J. , Alden Mitchell , Thomes Pepin Jessica , Ellerton John A. , Poklepovic Andrew , Walter Adam , Rampurwala Murtuza M. , Robinson William R. , Kim Hye Sung , Chung Liam Il-Young , McLeod Christine M. , Lopez Gabby , Chen Helen X. , Sharon Elad , Streicher Howard , Ryan Christopher W. , Blanke Charles D. , Kurzrock Razelle
Published: December 2024

AbstractPurpose:
The role of dual checkpoint inhibition (ipilimumab at 1 mg/kg intravenously every 6 weeks and nivolumab at 240 mg intravenously every 2 weeks) in advanced rare/ultrarare nonepithelial ovarian cancers is yet to be explored.
Patients and Methods:
Dual anti–CTLA-4 and anti–PD-1 blockade in rare tumor is a prospective, multicenter (1,016 US sites), multicohort, single-arm phase II trial conducted through the Early Therapeutics and Rare Cancer SWOG/NCI Committee, assessing ipilimumab (anti–CTLA-4; 1 mg/kg every 6 weeks) and nivolumab (anti–PD-1; 240 mg every 2 weeks) in adults with advanced nonepithelial ovarian cancers who lack beneficial standard therapy. The primary outcome was overall response rate [ORR; complete response (CR)/partial response (PR)]; secondary outcomes were progression-free survival (PFS), overall survival, clinical benefit rate [stable disease (SD) ≥6 months plus ORR], and toxicity.
Results:
Seventeen patients (median age: 64; number of prior therapies ranged from 0 to 8 with no immunotherapy exposure; eight granulosa, six carcinosarcomas, one Sertoli–Leydig, one yolk sac, and one Wolffian) were evaluated. In granulosa cell tumors, ORR was 25% (n = 2/8; one CR and one PR) and clinical benefit rate was 50% (n = 4/8); PFS was 58.3 (CR), 50.7+ (PR), 30.4 (SD), and 8.7 (SD) months. Median PFS was 3.5 months [95% confidence interval, 1.7–11.2 months]; median overall survival was 42.5 months (95% confidence interval, 10.1 months–not reached). One Sertoli–Leydig cell tumor showed a 22% regression (PFS, 11.2 months). Carcinosarcomas had no response. Three participants (18%) discontinued treatment due to grade 3 to grade 4 adverse events.
Conclusions:
Ipilimumab–nivolumab shows activity in treatment-refractory granulosa cell tumors, with 25% (n = 2/8) of patients experiencing either CR or PR lasting more than 4 years.
Data from Efficacy, Safety, and Influence on the Tumor Microenvironment of Neoadjuvant Pembrolizumab plus Ramucirumab for PD-L1–Positive NSCLC: A Phase II Trial (EAST ENERGY)
Authors: Aokage Keiju , Koyama Shohei , Kumagai Shogo , Nomura Kotaro , Shimada Yoshihisa , Yoh Kiyotaka , Wakabayashi Masashi , Fukutani Miki , Furuya Hideki , Miyoshi Tomohiro , Tane Kenta , Samejima Joji , Taki Tetsuro , Hayashi Takuo , Matsubayashi Jun , Ishii Genichiro , Nishikawa Hiroyoshi , Ikeda Norihiko , Tsuboi Masahiro
Published: December 2024

AbstractPurpose:
Angiogenesis inhibitors are known to modify tumor immunity. Combination of angiogenesis inhibitors with immune checkpoint inhibitors has shown efficacy against many types of cancers, including non–small cell lung cancer (NSCLC). We investigated the feasibility of neoadjuvant therapy with pembrolizumab and ramucirumab, a VEGFR-2 antagonist for patients with PD-L1–positive NSCLC, and its influence on the tumor microenvironment.
Patients and Methods:
Patients with pathologically proven, PD-L1–positive, clinical stage IB to IIIA NSCLC were eligible. Patients received two cycles of pembrolizumab (200 mg/body) and ramucirumab (10 mg/kg) every 3 weeks. Surgery was scheduled 4 to 8 weeks after the last dose. The primary endpoint was the major pathologic response rate by a blinded independent pathologic review. The sample size was 24 patients. Exploratory endpoints were evaluated to elucidate the effects of neoadjuvant therapy on the tumor microenvironment.
Results:
The 24 eligible patients were enrolled between July 2019 and April 2022. The major pathologic response rate was 50.0% (90% confidence interval, 31.9%–68.1%). Six patients showed pathologic complete response. Grade 3 adverse events (AE) occurred in nine patients (37.5%), including three immune-related AEs (acute tubulointerstitial nephritis in two cases and polymyalgia rheumatica in one case). There were no grade 4 or 5 AEs. The transcriptome and multiplex IHC results suggested that tumors with greater CD8+ T-cell infiltration and higher expression of effector molecules at the baseline could show better sensitivity to treatment.
Conclusions:
This new neoadjuvant combination of pembrolizumab plus ramucirumab was feasible, and anti-VEGF agents may enhance the effects of immune checkpoint inhibitors.
Supplementary Table 2 from SpliceMutr Enables Pan-Cancer Analysis of Splicing-Derived Neoantigen Burden in Tumors
Authors: Palmer Theron , Kessler Michael D. , Shao Xiaoshan M. , Balan Archana , Yarchoan Mark , Zaidi Neeha , Lopez-Vidal Tamara Y. , Saeed Ali M. , Gore Jessica , Azad Nilofer S. , Jaffee Elizabeth M. , Favorov Alexander V. , Anagnostou Valsamo , Karchin Rachel , Gaykalova Daria A. , Fertig Elana J. , Danilova Ludmila
Published: December 2024

Supplementary Table S2. Splicing antigenicity differences between samples with mutated and samples without mutated splicing factor genes. The splicing antigenicity differences between samples with mutated and non-mutated splicing factors for all 119 chosen splicing factor genes and for each TCGA cancer subtype.
Multi-echo acquisition and thermal denoising advances precision functional imaging
Authors: Moser Julia , Nelson Steven M. , Koirala Sanju , Madison Thomas J. , Labonte Alyssa K. , Carrasco Cristian Morales , Feczko Eric , Moore Lucille A. , Lundquist Jacob T. , Weldon Kimberly B. , Grimsrud Gracie , Hufnagle Kristina , Ahmed Weli , Myers Michael J. , Adeyemo Babatunde , Snyder Abraham Z. , Gordon Evan M. , Dosenbach Nico U.F. , Tervo-Clemmens Brenden , Larsen Bart , Moeller Steen , Yacoub Essa , Vizioli Luca , Uğurbil Kamil , Laumann Timothy O. , Sylvester Chad M. , Fair Damien A.
Published: December 2024

The characterization of individual functional brain organization with Precision Functional Mapping has provided important insights in recent years in adults. However, little is known about the ontogeny of inter-individual differences in brain functional organization during human development. Precise characterization of systems organization during periods of high plasticity is likely to be essential for discoveries promoting lifelong health. Obtaining precision functional magnetic resonance imaging (fMRI) data during development has unique challenges that highlight the importance of establishing new methods to improve data acquisition, processing, and analysis. Here, we investigate two methods that can facilitate attaining this goal: multi-echo (ME) data acquisition and thermal noise removal with Noise Reduction with Distribution Corrected (NORDIC) principal component analysis. We applied these methods to precision fMRI data from adults, children, and newborn infants. In adults, both ME acquisitions and NORDIC increased temporal signal to noise ratio (tSNR) as well as the split-half reliability of functional connectivity matrices, with the combination helping more than either technique alone. The benefits of NORDIC denoising replicated in both our developmental samples. ME acquisitions revealed longer and more variable T2* relaxation times across the brain in infants relative to older children and adults, leading to major differences in the echo weighting for optimally combining ME data. This result suggests ME acquisitions may be a promising tool for optimizing developmental fMRI, albeit application in infants needs further investigation. The present work showcases methodological advances that improve Precision Functional Mapping in adults and developmental populations and, at the same time, highlights the need for further improvements in infant-specific fMRI.
Pacific New England: Reuben Tam's Archipelagic Landscapes
Authors: Shahi Kimia
Published: December 2024

Transit between far-flung islands shaped the life of Hawai'ian-born artist Reuben Tam: from his birthplace, Kauai, to Monhegan, his adopted home in Maine, and back. This essay explores how these archipelagic relations oriented Tam's landscape paintings towards the ocean's geophysical materiality, forging new painterly connections between Pacific and Atlantic worlds.
A new species of the genus Pedopodisma (Orthoptera, Acridoidea, Catantopidae) from Zhejiang Province, China
Authors: XIE XUANYI , PAN LUOJIA , YANG YILEI , BAI YI
Published: December 2024

A new species, Pedopodisma kuocangshan sp. nov. is described from Mount Kuocang, Zhejiang Province, Southeastern China. The type specimens are deposited in the School of life scineces, Taizhou University. The new species is allied to Pedopodisma protrocula Zheng, 1980, but differs in: body size larger, length of body:♂21.5–22.5mm, ♀24.5–29.5mm; longitudinal diameter of eye is 1.8 times length of subocular groove♀, 1.9 times♂; antennae length of a segment in the middle is about 3.0 times width; lateral lobe of pronotum at lower margin rounded at anterior corner, posterior corner obtusely angulate; cercus of male at lower margin relatively straight and epiphallus at lower margin deeply concaved, lophi small and cuspidal at the back end.
Three new species of Melychiopharis (Araneae, Araneidae) from Ecuador and Peru
Authors: DUPÉRRÉ NADINE , TAPIA ELICIO , MARUSIK YURI , ESKOV KIRILL
Published: December 2024

Three new species of the peculiar Neotropical endemic genus Melychiopharis Simon, 1895, previously known from two species from Brazil, are herein described: from Ecuador, M. komischetier Dupérré & Tapia sp. nov. (♂♀) and M. davincii Dupérré & Tapia sp. nov. (♂); from Peru, M. peruviana Eskov & Marusik sp. nov. (♂♀). Scanning electron microscope images of the spinnerets and male palp are presented for the first time and a distribution map of all Melychiopharis species occurring in South America is presented.
Potamalpheops yamakawai n. sp., representing the first record of the genus from Japan (Decapoda: Caridea: Alpheidae)
Authors: YAMASHITA RYUNOSUKE , KOMAI TOMOYUKI , KOREEDA REO
Published: December 2024

In the present study, a new species of the alpheid shrimp genus Potamalpheops Powell, 1979, Potamalpheops yamakawai, is described from Japan. The new species, representing the first species of the genus to be recorded from the Japanese waters, appears to be close to P. miyai Yeo & Ng, 1997, known from mangroves in Indonesia and the Philippines, among the 16 previously known congeners. The non-setose ventrolateral margin of the carapace, the lack of spiniform setae on the pereopod 5 merus, the simple posterolateral tooth of the uropodal exopod and the overall colouration distinguish P. yamakawai sp. nov. from P. miyai. Genetic analysis using the mitochondrial 16S rRNA gene suggests that the new taxon is not conspecific with P. miyai. Specimens of the new species were collected from upstream of tidal limit to estuarine habitats, sometimes inhabiting burrows of other animals.
Forensic Elemental Analysis of Five Rupee and One Pound Coin with EDXRF Technique
Authors: null Richa , Kumari Manoj , Kumar Rajive , Tiwari Manoj
Published: December 2024

Energy dispersive X-ray Fluorescence (EDXRF) technique using synchrotron radiation has been employed for elemental analysis of one pound and five rupees coins of two different countries- the UK and India. Total number of 12 coins - 4 one pound and 8 five rupees coin were analysed. A Peltier cooled Vortex solid state detector (SII Nano Technology, USA) having energy resolution of 138 eV at 5.96 keV X-rays was employed for the present analysis. A Peltier cooled Vortex solid state detector (SII Nano Technology, USA) having energy resolution of 138 eV at 5.96 keV X-rays was employed for the present analysis. The investigations were carried out to determine the similarities between the elemental composition and structure of coins. The major elements Cu, Ni, Fe, Cr and traces of two elements Mn and Mo were found during analysis. One of the elements i.e. Cu was found as primary major element in most of the coins. Two other elements Fe and Cr are also found as major element in 2 five rupees coins. Fe was generally considered as cheap metal composition in comparison to Cu. Besides these traces of Mo, S, Ca and Si were also observed whose compositional amount found very low (below 1%). The present study confirms the favorable economic conditions of two countries during their minting time. The XRF spectra and graphical representation of elemental concentration also helps to identify the similarities in structure and composition of coins. Results of present analysis of different types of coins are found in good agreement with standard composition and also with each other. The EDXRF analysis shows its effectiveness in forensic science without alteration of precious samples. Forensic analysis of such coins using Synchrotron radiation is very helpful in archeological study.
The Formula "Well Regulated" in the Second Amendment to the US Constitution Cannot Be Ignored
Authors: Krasnyanskyy Mykhaylo
Published: December 2024

The article argues that the formula “well regulated” is an integral part of the 2nd Amendment to the US Constitution; the "well regulated" requirement (like the entire 2nd Amendment) completely applies to firearms and cannot be ignored under any interpretation or expansion of the Second Amendment. Failure to comply with the constitutional formula "well regulated" by all branches of US power has led to an unprecedentedly high "gun death" rate in the US, as well as the widespread use of American firearms by Mexican drug cartels. About 21,000 murders (including more than 2500 children) and 26,000 suicides in the US using firearms for one year 2021 cannot be considered as "well regulated" – i.e., not all requirements of the 2nd Amendment are obeyed. Obviously, ever since persons plotting a crime have been able to legally purchase, semi-automatic multi-charge firearms like the AR-15 with a rate of fire of over 100 rounds per minute, this inevitably led to numerous victims of civilian Americans. The concept of "originalism" as well as the concept "textualism" are incompatible with ignoring the constitutional formula “well regulated.
Microbiological Quality of Raw Camel Milk Consumed in the Zinder Region (Niger)
Authors: Doutoum Abdelsalam , Allamine Hisseine , Nazal Alhadj , Sakhaïroun Abdoulaye , Mahamadou Chaibou
Published: December 2024

Camel milk is a highly distinctive product for camel-rearing populations. However, camel milk production must be strictly controlled due to the potential risks it may pose to human health. The objective of this study is to evaluate the microbiological quality of processed milk camels from the Zinder region. The study which was conducted in Niger in the department of Tesker (Zinder), was conducted on 34 samples from camels depending on the availability of breeders and also the docility of the females. Seven (7) categories of germs were searched for through microbiological analysis FMAT, Total Coliforms, Escherichia coli, Staphylococcus aureus, Salomonella ssp, Colostriduum perfringens and fungal flora. For the assessment of the microbiological quality of milk, the results of our analyses are expressed according to the reference standards of the Luxembourg Food Safety Directorate (DSA/Luxembourg). These standards are listed in the table below. The microbiological quality of camel milk samples is not compliant to the standards for germs Total Aerobic Mesophilic Flora (85.29%), Staphylococcus aureus (61.76 %) and Yeasts (94.11%) and Molds (38.23%) and with respective average loads in CFU/ml: 1251.79 105; 34.12 102; 612.74 103; 10.15 103. Total Coliform Germs, E. coli, Salmonella ssp and Clostridium perfringens were absent in all samples analyzed. These results demonstrate a lack of compliance with good production hygiene practices during milking. Consumers would be exposed to a real danger to their health if nothing is done to improve the microbiological quality of raw milk.