bluuebunny/crossref_metadata_2025 huggingface dataset:
Driving Agility, Creativity, and Equity Through Strategic Compensation in Multinational Corporations
Authors: Krisdianto Muhammad Azeem Rahman , Khasan Singgih Fuad , Primadana Azmi Azhari , Mahdalena Mahdalena , Rhamadani Rhamadani , Hidayati Dini , Claudia Meiske
Published: February 2025

In the competitive global labor market era, employee retention remains a critical concern for multinational corporations (MNCs). This study emphasizes their role in attracting and retaining skilled leaders and efforts to explore the intricate dynamics of executive compensation frameworks. Organizational size and operational complexity emerge as primary determinants of executive pay, with larger firms offering higher salaries to address managerial challenges. The compensation positively relates to administrative expenditures as a reflection of resource allocation needs, while subsidy intensity imposes adverse effects due to regulatory and budgetary constraints. Asset turnover moderately impacts pay structures and gauzes operational efficiency, while compensation in high-uncertainty sectors aligns with risk-reward tradeoff theories significantly affected by industry risk. Equity-based incentives and tailored compensation strategies enhance retention by aligning employee goals with organizational objectives. Further strengthening employee engagement and trust is determined by the success of the integration of corporate social responsibility (CSR) principles and sustainability goals, finally, into compensation systems. Additionally, technological advancements facilitate immediate performance assessment and transparent reward distribution, fostering inclusivity and fairness. Diagnostic tests validate the robustness of the compensation model, which explains 22.4% of the variance in pay, highlighting areas for future research, such as governance frameworks and employee satisfaction. This study critically elucidates regulatory frameworks for advocating transparent, precise reporting mechanisms and collaborative public-private initiatives into actionable insights for policymakers and organizations. Thus, the research shows that these strategies align compensation systems with societal priorities, ensuring the goal of a sustainable balance between corporate competitiveness and social equity.
Synergistic Effects of Vitamin D and Stem Cell Therapy in Treating Eosinophilic Chronic Rhinosinusitis (ECRS)
Authors: Restimulia Lia
Published: February 2025

Eosinophilic Chronic Rhinosinusitis (ECRS) is a chronic and debilitating inflammatory disorder affecting the mucosal lining of the nose and sinus, characterized by an increased infiltration of eosinophils, which contribute to tissue damage and the exacerbation of symptoms. Conventional treatments, such as corticosteroids and surgery, commonly offer limited benefit and entail potential for recurrence. Recently, vitamin D, in addition to stem cell therapy, is beneficial therapeutic synergistic option for ECRS. This qualitative study explores the potential effects of vitamin D supplementation and stem cell therapy, analyzing their interactions and therapeutic potential in ECRS treatment. We explore the immunomodulatory properties of Vitamin D, which has the potential to regulate immune responses and reduce eosinophilic inflammation through a review of existing literature and expert insights. Concurrently, stem cell therapy is investigated for its potential to improve healing in chronic rhinosinusitis, given its properties to encourage tissue regeneration and alter inflammation. The findings indicate that the combination of Vitamin D and stem cell therapy could lead to improved symptom management, reduced inflammation, and enhanced tissue regeneration, offering a holistic approach to treating ECRS. The result are encouraging, but further clinical trials and studies will be needed to confirm these findings and treatment protocols. We summerize the implications of vitamin D and stem cell therapy as a promising novel approach in ECRS treatment to motivate further research on their application.
relationship between helicobacter pylori infection and iron deficiency anemia in Yemeni adults
Authors: Al-absi Boshra , Al-Henhena Nawal , Almorish Mohammed Abdul Wahid , Othman Arwa Mohammed
Published: February 2025

Background: Iron deficiency anemia (IDA) is a prevalent nutritional and hematological disorder. Although Helicobacter pylori (H. pylori) is known for its association with gastritis, peptic ulcers, and gastric cancer, emerging evidence indicates a significant relationship between this bacterium and extra-gastroduodenal conditions, such as IDA. This study aimed to investigate the association between H. pylori infection and iron deficiency anemia.
Materials and Methods: This case-control study included 100 individuals aged 18-56. Fifty H. pylori  -positive patients and 50 healthy controls were enrolled from the gastroenterology clinics. The stool samples were analyzed for H. pylori antigens and occult blood samples. Blood samples were collected for complete blood count and iron profile assessment using an automated system.
Results: There were no significant differences in sociodemographic features and risk factors between the patients and controls. 90 \% of patients and 92\% of controls did not have anemia; 26\% and 18\% of patients and controls had low ferritin levels, respectively. No significant differences in hematological parameters, serum iron, or ferritin levels were observed between H. pylori -infected patients and controls. On the other hand, the total iron-binding capacity (TIBC) and unsaturated iron-binding capacity (UIBC) were not significantly higher in patients than in controls.
Conclusion : H. pylori infection is not associated with IDA. The levels of hemoglobin, serum iron, ferritin, TIBC, and UIBC were not significantly altered in H. pylori -infected participants who did not exhibit gastrointestinal bleeding.
Hearing Restoration in Sensorineural Loss: A Prospective Cohort Study of Intratympanic Platelet-Rich Plasma Instillation in Yemen
Authors: Al-Ghaili Adel Abdo , Al-Ansi Wael Hamoud , Aldumaini Amal , Jowah Haitham
Published: February 2025

Background: This study aimed to evaluate the efficacy and safety of intratympanic PRP injection for the treatment of SNHL in Yemen and to identify predictors of successful treatment outcomes.
Methods: This prospective cohort study included 120 patients diagnosed with SNHL at the Military General Hospital in Yemen. The patients received intratympanic PRP injections and were followed up for 3 months. Pure-tone audiometry (PTA) was performed to assess hearing thresholds before and after treatment. Demographic and clinical characteristics, including etiology and duration of hearing loss, were collected. Statistical analysis was performed to evaluate the treatment outcomes and identify significant predictors.
Results: The study cohort comprised 36 women (30%) and 84 men (70%), with a mean age of 29.72 ± 11.85 years. The most common etiologies were noise-induced hearing loss (35.8%) and sudden hearing loss (30%). Posttreatment, significant improvement in PTA hearing thresholds was observed, with mean thresholds improving from 48.27 ± 17.77 dB HL to 31.56 ± 20.45 dB HL (p < 0.05). Patients with pre-treatment hearing levels of 26-45 dB showed the highest improvement rates, with 100% achieving a final hearing level of ≤ 25 dB. The etiology of SNHL was a significant predictor of better outcomes (p = 0.002), whereas age, sex, and duration of hearing loss did not significantly affect treatment outcomes. The treatment was well-tolerated, with minor adverse effects observed in a small percentage of patients.
\newline\textbf {Conclusion: } Intratympanic injections of PRP are an effective and safe treatment for improving hearing thresholds in patients with SNHL, particularly in resource-limited settings like Yemen. Early intervention and tailored treatment strategies based on etiology are crucial for optimizing the outcomes. Further studies with larger sample sizes and longer follow-up periods are required to establish the long-term efficacy and safety of PRP therapy in patients with SNHL.
 
Conventions: Abbreviations are usually defined at the first use in the abstract. Check whether 'PRP' should be defined here.
 
Consistency: Different forms of this word have been used in the text.'posttreatment' no space [4 times] 'post-treatment' with hyphen [4 times] Please pick one style and use it consistently throughout the text.
 
Consistency: Different forms of this word have been used in the text.'pre-treatment' with hyphen [7 times] 'pretreatment' no space [3 times] Please pick one style and use it consistently throughout the text.
 
Conventions: Abbreviations are usually defined at the first use in the abstract. Check whether 'SNHL' should be defined here.
Risk Factors Associated with Atopic Asthma among Yemeni Children in Sana’a city: A Case-Control Study
Authors: Masood Haitham , Abdul-Mughni Gamil Taher , Othman Arwa Mohammed , Al-Sonboli Najla Nasr Addin , Ghlab Faiza Abdulnoor
Published: February 2025

Background : Asthma is the most common chronic respiratory disease, affecting millions of people of all ages worldwide. The average global prevalence ranges from 5 to 10%. Asthma is influenced by complex interactions between particular external factors such as pollution, viral and bacterial infections, allergens, and tobacco smoke, as well as an individual’s genetic makeup. This study aimed to determine the risk factors associated with atopic asthma in children in Sana’a City, Yemen.
Methods: This case-control study included 75 Yemeni children diagnosed with bronchial asthma and 75 healthy control children, matched for age and sex. Data were collected from each participant using a pre-designed questionnaire. Clinical assessments by a pulmonologist confirmed the definitive diagnosis of bronchial asthma in children. Laboratory confirmation was performed by measuring both serum Interleukin-13 (IL-13) levels using enzyme-linked immunosorbent assay (ELISA) and serum Immunoglobulin E (IgE) levels using the electrochemiluminescence technique.
Results: Living in urban areas served as a protective factor and was associated with a lower likelihood of atopic asthma in children than in those living in rural areas (χ2=5.4, OR = 0.3, CI = 0.08-0.9, p = 0.03). Similarly, the use of gas only in the kitchen serves as a protective factor and is linked to a reduced likelihood of atopic asthma in children compared to using a mixture of gas and wood (χ2  =7.9, OR = 0.08, CI = 0.01 - 0.7, p = 0.02). Although family history and the presence of other allergic disease factors were associated with atopic asthma in the univariate analysis, their significance was not maintained in the multivariate logistic regression model.
 Conclusion: The findings suggest that living in urban areas and using gas as the sole fuel source in the kitchen are associated with a lower risk of atopic asthma. The authors also highlighted the significant role of environmental factors in atopic asthma.
The Dismissal of the Romanian Prosecutors Annulment Action
Authors: Lobina Benedetta , Meera Maharaj Candice
Published: February 2025

In the latest chapter of the EU rule of law saga, the General Court dismissed an annulment action lodged by an association of Romanian prosecutors, which challenged the termination of the Cooperation and Verification Mechanism in 2023, due to lack of direct concern. We argue that a too-narrow view of the issue does not reflect the rule of law situation in the country, including open non-compliance with the CJEU’s own rulings, and leads to several undesired consequences.
Capítulo 11: Caracterización de microplásticos y mesoplásticos en los sedimentos de playa del río Magdalena en la ciudad de Neiva
Authors:   Corporación Universitaria del Huila (CORHUILA), Calderón Ramírez Juliana Andrea , Pimentel Correa Santiago ,   Corporación Universitaria del Huila (CORHUILA), Martínez Silva Paula ,   Corporación Universitaria del Huila (CORHUILA)
Published: February 2025

Los plásticos, esenciales en el desarrollo tecnológico y la vida cotidiana, han generado una demanda creciente que los posiciona como materiales contaminantes de gran impacto ambiental (Porras, 2021). Los plásticos de un solo uso son los más populares por su bajo costo y practicidad, fomentando una cultura de desecho y manejo inadecuado de residuos (López et al., 2020). Al degradarse lentamente, generan partículas como nano, micro y mesoplásticos, que afectan los ecosistemas acuáticos y su biodiversidad (Porras, 2021). Los microplásticos, de 1 µm a 5 mm, incluyen fibras, fragmentos y microesferas, mientras que los mesoplásticos, de 5 mm-25 mm, son fragmentos mayores difíciles de remover (TecnoAqua, 2019). Ambos interfieren con la cadena trófica y actúan como vectores de contaminantes (Manrique, 2019). En el río Magdalena, se analizaron sedimentos de cinco puntos cerca de Neiva. Predominaron fibras en el punto 1 (189), cercano a zonas industriales, mientras que las microesferas fueron más comunes en el punto 3 (28), asociadas a productos industriales. El punto 2, influido por actividades turísticas y aguas residuales, presentó altos niveles (130). Estas variaciones reflejan la influencia humana en la contaminación del ecosistema acuático.
Capítulo 15: Influencia de la bovinaza como medio de cultivo y el fotoperiodo en la producción de Arthrospira sp
Authors:   Instituto Universitario de la Paz, Rueda Jaimes Andrés Gilberto , Buitrago Ibáñez Daniel Augusto ,   Instituto Universitario de la Paz, Vera Alzate Gerson Andrés ,   Instituto Universitario de la Paz, Salazar Beleño Ana Milena ,   Instituto Universitario de la Paz, Montesino Rincón Sandra Milena ,   Instituto Universitario de la Paz, Porras Atencia Oscar Orlando ,   Instituto Universitario de la Paz
Published: February 2025

El presente proyecto de investigación pretende evidenciar cómo las diferentes variables inciden en el crecimiento de Arthrospira sp, bajo un sistema controlado utilizando bovinaza como sustrato de crecimiento, además de la influencia de la luz UV en la producción de la misma. Para esto se buscó evaluar la influencia de la luz ultravioleta y el uso de bovinaza mediante la siguiente metodología: (1) Cultivo, con fotoperiodo de 12:12 hasta la obtención de la colonia. (2) Cultivo en medio Zarrouk modificado y bovinaza a concentraciones de 10, 25, 50, 75, 90, 100% P/V, además de examinar la influencia de lámparas UV-B, exposición de luz led blanco y exposición solar. (3) Evaluar la tasa de crecimiento a partir del recuento celular durante 16 días. (4) Finalmente, se procedió al análisis fisicoquímico de la biomasa deshidratada. Como resultados, se determinó a concentraciones mayores del 50% de bovinaza una concentración mayor de microorganismos lisos, además de una mayor tasa de crecimiento al ser expuestas a la luz solar. Finalmente, se obtuvo una productividad de biomasa seca de 0,326 ± 0,006g/L.día, un contenido de 0,24% de lípidos, 7,9% de proteínas y 51,31% de cenizas, reportando también la ausencia de microorganismos que afectan su crecimiento.
Capítulo 22: Impacto de las políticas públicas en la organización administrativa colombiana: una revisión sistemática
Authors:   Corporación Universitaria del Caribe, Rodríguez Zambrano Henry Mario , Prieto Baldovino Francia Helena ,   Universidad del Sinú, Camacho Alvis Estrella ,   Universidad del Sinú, Jiménez Paternina Lucimio ,   Corporación Universitaria del Caribe
Published: February 2025

Este artículo examina el impacto de las políticas de evaluación de la gestión pública en Colombia desde la implementación de la Ley 489 de 1998, destacando su influencia en la eficiencia administrativa y la satisfacción ciudadana. Mediante una revisión sistemática de fuentes primarias y secundarias, se identifican avances significativos y retos persistentes en la evaluación de la gestión pública y del desempeño. La estrategia de búsqueda incluyó bases de datos académicas y específicas de Colombia, con un enfoque en documentos publicados desde 1998. La investigación pretende identificar una evolución legislativa y tecnológica orientada a mejorar la evaluación y gestión pública, y resaltar la necesidad de incluir diversas voces y enfoques, como los derechos humanos, en futuras investigaciones para fortalecer la gestión pública en Colombia.
Efficacy and Safety of Robot-Assisted and Sternotomy for Mitral Valve Repair in the Treatment of Mitral Regurgitation: A Systematic Review and Meta-Analysis
Authors: Fu Tao , Huang Yan Fei , Guo Hong Ying , Long Jin Ting , Qian Chen , Xiao Fang , Chen Ting Jie
Published: February 2025

Background: Current research comparing the efficacy of robot-assisted mitral valve repair with sternotomy presents inconsistent results. This meta-analysis compares the advantages and disadvantages of robot-assisted mitral valve repair versus sternotomy, providing clinicians with a clearer reference for surgical decision-making. Methods: We systematically searched the PubMed, Embase, and Cochrane Library databases for studies published from inception to September 2021. Cohort studies were included where the observation group underwent robot-assisted surgery, and the control group received sternotomy. We excluded repeated publications, studies lacking full text, incomplete data, animal studies, and reviews/systematic reviews. Data were analyzed using STATA 15.1. Results: The pooled results showed that the operation time (weighted mean difference (WMD) = 43.95, 95% confidence interval (CI): 36.53–51.36), aortic cross-clamp time (WMD = 26.72, 95% CI: 15.48–37.96), and cardiopulmonary bypass time (WMD = 39.50, 95% CI: 29.52–49.47) were significantly longer for robotic surgery compared to the sternotomy group. However, robotic surgery resulted in significantly shorter lengths of intensive care unit (ICU) stay (WMD = –25.43, 95% CI: –37.21–13.66) and hospital stay (WMD = –1.58, 95% CI: –2.26– –0.89) compared to sternotomy. The blood transfusion rate was significantly lower in the robotic surgery group (odds ratio (OR) = 0.66, 95% CI: 0.47–0.94). Furthermore, the mortality rate was significantly lower for robotic surgery (OR = 0.32, 95% CI: 0.17–0.60). Conclusion: Although robot-assisted mitral valve repair requires longer cross-clamp time, cardiopulmonary bypass time, and operation time compared to sternotomy, it results in shorter ICU and hospital stays, a lower blood transfusion rate, and a reduced mortality rate.
The Impact of Sun's Procedure on Postoperative Aortic Remodeling in Patients with Retrograde and Classic Type A Aortic Dissections
Authors: Xia Jinhai , Luo Chaoen , Khan Asfandyar , Long Chaozhong , He Dapu , Feng Yaoguang , Lei Zhengwen
Published: February 2025

Background: This study aims to compare the impact of Sun's procedure on distal aortic remodeling in patients with acute Stanford type A aortic dissection (TAAD), including retrograde TAAD (RTAAD) and classical TAAD. The procedure's role in promoting distal aortic remodeling is assessed, along with potential differences in outcomes between the two subtypes of type A aortic dissection. Methods: A total of 76 patients diagnosed with TAAD, including 31 with RTAAD and 45 with classical TAAD were enrolled between November 2019 and May 2023. Using Carestream Image Suite V4, true and false lumen areas were retrospectively analyzed at five anatomical planes (pulmonary artery, abdominal trunk, superior mesenteric artery, left renal artery opening, and inferior mesenteric artery) preoperatively and three months postoperatively. Distal aortic remodeling outcomes were compared between the two groups. Results: Both the TAAD and retrograde type A aortic dissection (RTAAD) groups underwent Sun's procedure, consisting of total arch replacement, distal frozen elephant trunk technique, and ascending aorta replacement. In TAAD, the primary tear was excised through ascending aorta replacement, and stent expansion was used to enlarge the true lumen of the descending aorta. In RTAAD, stent grafts isolated the primary tear in the descending aorta and expanded the true lumen. No significant differences were observed between the groups in short-term distal aortic remodeling. There were no significant differences between the two groups in baseline characteristics, including sex, age, smoking history, hypertension, diabetes, coronary heart disease, and hyperlipidemia. Conclusions: These findings suggest that postoperative distal aortic remodeling may be influenced by factors beyond dissection type. Furthermore, Sun's procedure is an effective surgical approach for both TAAD and RTAAD patients.
Influence of Knowledge and Attitudes About Prohibited Cosmetic Substances on Generation Z's Online Purchases in Lampang
Authors: Boonlong Chanidapha
Published: February 2025

Background and Aims: This study investigates how knowledge of prohibited substances in cosmetics and attitudes toward these substances influence the purchasing decisions of Generation Z consumers on online platforms in Lampang Province. Online platforms have become a dominant marketplace for cosmetics, but concerns about harmful ingredients such as mercury and hydroquinone have raised awareness among consumers. Understanding these factors can provide insights into consumer behavior and support safer purchasing practices. Lampang Province represents an emerging market with increasing online cosmetic purchases among Generation Z."
Methodology: The study employed a cross-sectional analytical research design with 390 Generation Z participants residing in Lampang Province. Data were collected through a structured questionnaire covering demographic information, knowledge of prohibited substances in cosmetics, attitudes toward these substances, and purchasing decision behavior. The data were analyzed using descriptive statistics and multiple regression analysis.
Results: The findings reveal that both knowledge and attitudes toward prohibited substances significantly influence purchasing decisions. Consumers with a higher knowledge of harmful substances tend to avoid products containing these ingredients. Similarly, negative attitudes toward prohibited substances encourage safer purchasing behavior. Regression analysis demonstrated a strong positive relationship between these variables and purchasing decisions, with attitudes having a slightly greater impact than knowledge.
Conclusion: The study concludes that knowledge and attitudes about prohibited substances in cosmetics play crucial roles in shaping purchasing decisions among Generation Z consumers in Lampang Province. These findings highlight the importance of education and transparent product labeling in promoting safer online purchasing behaviors.
Analisis Identifikasi Bahaya Dengan Metode HIRADC Dalam Meningkatkan Keselamatan & Kesehatan Kerja Di UPTD Puskesmas Miroto Kota Semarang
Authors: Zahra Auliya , Fitri Hapsari Nadia
Published: February 2025

Keselamatan dan Kesehatan Kerja yaitu langkah dalam mewujudkan kondisi kerja yang tentram serta nyaman bagi pekerja, sehingga dapat meningkatkan produktivitas mereka di tempat kerja. Dalam rangka meningkatkan kualitas pelayanan, puskesmas harus melihat aspek kesehatan dan keselamatan pekerja guna mengurangi potensi insiden kerja dan penyakit serta melindungi semua pekerja, pasien, dan pengunjung puskesmas. Puskesmas Miroto adalah salah satu puskesmas non-rawat inap yang berada di Kecamatan Semarang Tengah. Penelitian ini bertujuan untuk mengidentifikasi potensi risiko K3 di Puskesmas Miroto dengan mengidentifikasi bahaya yang ada di ruang pelayanan puskesmas menggunakan metode HIRADC. Penelitian ini menggunakan pendekatan observasional deskriptif. Data dikumpulkan  dengan mengobservasi langsung di lapangan serta wawancara dengan tenaga kerja, yang mencakup pencatatan insiden K3, perilaku pekerja, serta pengamatan terhadap objek yang ada selama kegiatan pelayanan kesehatan masyarakat di Puskesmas Miroto. Proses identifikasi risiko dilakukan pada ruang poli gigi dan mulut, di mana potensi bahaya tertinggi yang teridentifikasi meliputi bahaya ergonomis, risiko penularan infeksi penyakit dari pasien, serta kemungkinan terjadinya pemadaman listrik. Pengendalian risiko perlu diterapkan untuk mencegah dan mengurangi kecelakaan di puskesmas
Preoperative and Postoperative Nutritional Support Methods For Pancreatic Cancer: A Review
Authors: Tao Terri Jinyi
Published: February 2025

Pancreatic cancer (PC) is a highly malignant neoplasm often detected at an advanced stage, resulting in a poor prognosis. Major risk factors include cigarette smoking, excessive alcohol consumption, obesity, and genetic predisposition. Malnutrition, cachexia, and sarcopenia are prevalent among PC patients and significantly impact clinical outcomes. Evidence suggests that perioperative nutritional interventions—ranging from early screening and assessment to oral supplementation, pancreatic enzyme replacement therapy, and enteral or parenteral nutrition—can alleviate postoperative complications, shorten hospital stays, and enhance quality of life. Early refeeding and stepwise dietary advancement are vital to maintaining gastrointestinal function and meeting energy requirements. In addition, continuing patient education and home-based nutritional management after discharge are crucial, as many patients remain at high risk of nutritional deficits postoperatively. Despite these benefits, standardized disease-specific guidelines for nutritional support in PC are still lacking, and further investigation is required to determine optimal strategies and timing for interventions. Multidisciplinary collaboration, involving surgeons, oncologists, and dietitians, is essential for addressing the multifaceted nutritional challenges encountered by PC patients and for improving both survival and quality of life. Future research should also focus on refining assessment tools, identifying specific biomarkers, and evaluating long-term outcomes to establish more targeted nutritional guidelines for PC care.
Research for the Sleep Health and the Lifestyle Relationship
Authors: Ren Fengyi
Published: February 2025

The health of sleep is a main factor determining people’s daily lives, which depends on lifestyle in many aspects. The study is based on the dataset Laksika Tharmalingam generated for the statistical analyses of sleep health and lifestyle. The research uses linear regression to analyze sleep health effect factors by the relationship of sleep duration, people’s quality of sleep, which is self-reported, and the lifestyle of physical activity, people’s daily steps, and stress level. Participants consisted of 374 individuals from different occupations from age 27 to 59, both male and female. The research mainly focuses on the physical activity, daily steps, and stress levels of people with people’s sleep health. Across the sample, physical activity level and step quality positively correlated with sleep health, and stress level of people is negatively correlated with people’s sleep health. Sleep quality is statistically significantly impacted by step quantities and stress levels, which can also have significant effects on sleep health. However, the amount of physical exercise has no statistical impact on sleep quality.
Application of Diabetes medical treatment combination in China
Authors: Zhu Yuchen , Jiang Fengyun , Zhang Xingyu , Jiang Jingyan , Yao Jianru
Published: February 2025

With the progress of the times and the development of society, opportunities and challenges coexist in contemporary society. As one of the chronic diseases with the highest prevalence rate, diabetes has brought a huge crisis to people’s daily life. Under the modern medical system, many difficult problems of diabetes patients seeking medical treatment can be solved through hierarchical diagnosis and treatment, and the pressure of outpatient service can be shared. At the same time, the use of many medical treatment combinations can make diabetes patients no longer need lifelong medication, but can replace “lifelong medication” with “lifelong management” through “diabetes reversal”. As a leading country in the treatment and prevention of diabetes using the medical treatment combination model, China has created a unique reverse outpatient model under the concept of traditional Chinese medicine. The purpose of this paper is to explore the role of medical treatment combination in promoting the treatment of diabetes from the perspective of health economy and public management mechanism.
Ginsenoside Rb decreases the TSCC tumor cell viability and promotes apoptosis to decrease the tumor size by interacting with E-cadherin
Authors: Wang Yuqi
Published: February 2025

Ginsenoside Rd is a small molecule compound found in ginseng. In traditional Chinese medicine theory, it has anti-inflammatory, anti-edema, blood-activating, and debriding effects. In recent clinical trials, Rd has shown an effect of promoting cancer cell apoptosis, especially for oral cancer, with good curative effects. The specific mechanism of Rd treating cancer is not clear. Another recent study on the e-cadherin protein in cancer cells has given us a new research direction. ECAD is a major calcium-dependent adhesion molecule that is mainly found in cell adhesion in the cell and is usually considered an anti-cancer factor. However, recent research has shown that ECAD is crucial for maintaining cancer cell viability, and it can reduce the content of intracellular ROS by inhibiting TGF-β, P53, and other cellular pathways, thereby reducing the probability of cell death due to oxidative stress. In a series of experiments, a large reduction of ECAD resulted in increased cell apoptosis. This phenomenon is very similar to the effect of Rd on cancer cells. Therefore, this paper aims to study whether the mechanism of Rd treating cancer is related to E-cad.
The mechanism of zolpidem and ramelteon to treat insomnia
Authors: Cao Shengqi
Published: February 2025

Insomnia, characterized by difficulty in getting or keeping sleep, has a serious impact on daytime performance and health. Zolpidem, a GABA-A receptor modulator, reduces sleep latency and increases sleep duration, making it suitable for short-term use. Ramelteon, a melatonin receptor agonist, regulates circadian rhythms and is effective for chronic insomnia, but is not addictive. The choice between zolpidem and ramelteon depends on the type of insomnia, and non-pharmacological treatments such as cognitive-behavioral therapy are recommended as a first choice. It is hoped that future treatments for insomnia will become safer and more personalized, combining medication with behavioral therapy to supplement treatment.
Quantitative Analysis of the Relationship Between Diabetes and Various Health Indicators
Authors: Liu Chenxi
Published: February 2025

Diabetes is a chronic, widespread disease that affects millions globally. This disease impairs the body’s ability to manage blood glucose levels due to inadequate insulin production or reduced insulin efficiency, resulting in hyperglycemia, which causes severe health risks and economic burdens The prevalence and death rate is increasing, especially in low- and middle-income countries. This study analyzes the 2015 Behavioral Risk Factor Surveillance System (BRFSS) dataset, which contains a total of 253,680 survey responses, with 21 variables. In this study, multiple logistic regression, Pearson correlation, and chi-square tests were applied to find the independence and association of different health indicate factors like high blood pressure, high cholesterol, body mass index, smoking, stroke, and heart disease to diabetes risk. The results indicate that diabetes is closely related to health indicators such as High BP, HighChol, and BMI. Smoking alone has a minor effect on the diabetes. The income level has a negative association with diabetes; thus, one could have a higher income to protect against the disease. People with stroke are twice as likely to have diabetes as people without diabetes, which is likely because diabetes damages blood vessels. This study analyzed the various risk factors associated with diabetes, which can greatly help prevent and diagnose diabetes. It also highlights the need for continued research into how lifestyle, genetic, and socioeconomic factors interact to influence diabetes risk and contribute to diabetes prevention and health improvement.
Suppress the proliferation process of glioblastoma by breaking off the tumor - microenvironment interaction by CRIPSR -mediated technology
Authors: Wang Wei
Published: February 2025

Glioblastoma is a notorious malignant tumor and traits in cancer provide strong drug resistance. Current Traditional clinical treatments include chemotherapy and surgery, had been proved that showed insufficient effect towards glioblastoma, leading to the requirement of new therapy ------ CRISPR mediated technology therapy application. CRISPR is prior options for gene therapy drug design and using gene-editing principle from the molecular level. Scientists research evaluated the CRIPSR gene therapy had ability in editing related functions of glioblastomas and inducing an immune response by blocking the metabolic activity of cancer cells to achieve anti-cancer effects. We discussed the recent identified potential CRISPR gene therapy targeting sites in glioblastoma gene therapy, including clinical traits and in vivo experiments verified the value in future clinical treatment applications. We also discussed the relationship between the target sites of the glioblastoma genome and the traits they related with. Targeting the angiogenesis regulator factors leads to suppression of glioblastoma proliferation and inhibit the tumor growth. Mediated the tumor micro environment by enhancing antigen present process and reduce glioblastoma interaction with immune cells, could up regulated the anti-tumor immune response. The is also a possibility of combining immune therapy and CRIPSR gene editing therapy together by Car-T therapy. We also discuss the potential delivery method for CRISPR gene-editing therapy, compare the AAV virus method and nanocapsule for assist the edited gene reach the target sties and avoid off-target rate. The CRISPR therapy could be the mainstay in glioblastoma treatment by directly target the glioblastoma metabolism to inhibit tumor proliferation, and could increase survival rate in child glioblastoma treatment as the heterogeneity of glioblastoma is high.
Enhancing Solid Tumor Immunotherapy: A Multi-Model Strategy Integrating Synapse-Tuned CAR Cells with Oncolytic Virotherapy and Immune Checkpoint Modulation
Authors: Yan Qi , Mo Zihan , Tian Xiaxi , Wen Xinjun
Published: February 2025

Although past successes have been achieved in chimeric antigen receptor (CAR) T cell therapies in the past decade, especially in the field of hematology, they are not without challenges. CAR T cell therapies are fraught with problems for treating solid tumors such as melanoma, a frequently fatal skin cancer with increasing incidence in multiple regions. In 2020, there were a total of 325,000 new cases and around 57,000 deaths associated with the disease being reported (Saginala et al., 2021). The ineffectiveness of CAR T therapy for treating melanoma and other solid tumors can be attributed in part to the tumor’s immunosuppressive microenvironment, physical barriers, antigen heterogeneity, poor T cell infiltration and dynamic tumor biology. Therefore, in this study we propose an approach aimed at increasing the activation of CAR T cells and help CAR T cells to eliminate melanoma more effectively. Building on recently published work we propose to add a post-synaptic density-95, discs large and zona occuldens (PDZ) binding motif to the C-terminus of the CAR and CAR T cells are preloaded with oncolytic poliovirus. In our proposed system poliovirus would be engineered to express a Cas9 system to target PD-L1 gene and inhibit the expression of PD-L1, a well-known immune checkpoint protein. Overall, with the precise targeted killing of melanoma by poliovirus and enhanced activation of CAR T cells, this combined therapy holds promise to significantly improve the efficacy of solid tumor immunotherapy. This comprehensive approach offers promising directions for the development of more effective treatment strategies and their clinical translation.
Pig farming: challenges and perspectives
Authors:   Institute for Animal Husbandry, 11080, Belgrade, Serbia, Radović Čedomir , Živković Vladimir ,   Institute for Animal Husbandry, 11080, Belgrade, Serbia, Stojiljković Nenad ,   Institute for Animal Husbandry, 11080, Belgrade, Serbia, Radojković Dragan ,   University of Belgrade Faculty of Agriculture, Nemanjina 6, 11080 Belgrade, Serbia, Parunović Nenad ,   Institute of Meat Hygiene and Technology, 11000 Belgrade, Serbia, Petrović Aleksandra ,   Institute for Animal Husbandry, 11080, Belgrade, Serbia, Gogić Marija ,   Institute for Animal Husbandry, 11080, Belgrade, Serbia
Published: February 2025

Global pork production in 2022 increased by 1% compared to the previous year. The largest producer
of pork is still the People‘s Republic of China with 46%, followed by the EU with 18% and the USA with a 10%
share in total production. In the previous period, there were major disruptions in the market due to the emergence
of two 2020 COVID-19 viruses and the emergence of the African swine fever (ASF) virus in Ukraine in 2012.
The virus COVID-19 disrupted the market for two years with a declining impact from 2022, but the ASF virus
is not reducing its impact even today since its appearance. In Serbia, the largest number of euthanized pigs due
to ASF was in 2023, as well as in neighboring Croatia. Smaller farms were the most affected because they did
not have good biosecurity measures, and large pig breeders were endangered and at risk because of them. In
2024, the occurrence of ASF was recorded in four districts (15 villages) as well as in one municipality of the city
of Belgrade. Since the beginning of this year, we have had AFSderegistered in four districts, for 31 populated
places the decision on the area infected with the AFS virus has been revoked. When we talk about the market,
the cost price per kg of warm carcass side in 2022 is the highest in Italy (€2,894/kg of warm carcass side) with a
share of pig feeding costs of 62.89% and a share of labour costs of 5.18% per kg of warm carcass side, while in
Brazil ( Midwest) the price of producing a kg of warm carcass side is significantly lower and amounts to 1,412
euros per kg with a share of pig feeding costs of 77.20% and a share of labour costs of 2.83% in the cost price
of a kg of warm carcass side. Serbia is one of the few countries in Europe that has not introduced a system of
evaluating carcass sides on the slaughter line and paying fattening animals according to the estimated share of
meat in the carcass side, i.e. the meatiness of fattening animals, but mostly fattening animals are paid per kg of
live weight. Introduction of unbiased assessment of meatness on the slaughter line in Serbia would significantly
improve pig production in Serbia and increase the economy of pork production.
Seasonal changes of some biochemical indicators in four sheep herds from Bulgarian Dairy Synthetic Population
Authors:   Agricultural Academy, Institute of Animal Science –Kostinbrod, Bulgaria, Yanchev Ivan , Metodiev Nikola ,   Agricultural Academy, Institute of Animal Science –Kostinbrod, Bulgaria, Moneva Penka ,   Agricultural Academy, Institute of Animal Science –Kostinbrod, Bulgaria, Ignatova Maya ,   Agricultural Academy, Institute of Animal Science –Kostinbrod, Bulgaria
Published: February 2025

The purpose of the present study was to evaluate seasonal differences in the values of some enzymes
and metabolites - ALT, AST, ALP, serum iron, glucose, as well as WBC count and N/L ratio in four herds of
sheep from the Bulgarian Dairy Synthetic Population (BDSP), raised at different altitudes. The research was
conducted in sheep farms of the Sofia region - Ravnishte (391 m a.s.l.), IAS - Kostinbrod (548 m a.s.l.), Mirkovo
(715 m a.s.l.) and Bosnek (940 m a.s.l.). Blood samples were taken from selected 24 animals from each sheep
herd. Analysis of biochemical parameters was performed in extracted plasma by Semi-automatic Biochemical
Analyzer BTS-350 and WBC (leucocyte subpopulations, resp.) count was performed by 5-Part-Diff Automated
Haematology Analyzer.
We observed significant differences between seasons in all studied indicators except in WBC count (most in
B. and R.). In the summer season there were more significant differences between sheep farms in all studied
indicators compared to winter, except about the serum iron levels. All studied indices were within the reference
values for sheep, except about ALP activity and serum iron levels, which were lower than limits. The lack
of significant difference in total leukocyte count, but the presence of changes in subpopulations, indicated a
dynamic adaptation of the immune system to seasonal factors, such as infections, nutrition, stress and parasite
loads, i.e., N/L ratio, could be an indicator to seasonal (winter and summer) stress and criterion for selection for
stress resistance in sheep, depending on altitude.
Comparison infrared thermography of Balkan donkeys
Authors:   University of Forestry-Sofia, Faculty of Veterinary Medicine, 10 Kliment Ohridski Blvd., Sofia 1797 Bulgaria, Stamberov Petar , Hristov Kalin ,   University of Forestry-Sofia, Faculty of Veterinary Medicine, 10 Kliment Ohridski Blvd., Sofia 1797 Bulgaria, Stoimenov Aleksandar ,   University of Forestry-Sofia, Faculty of Veterinary Medicine, 10 Kliment Ohridski Blvd., Sofia 1797 Bulgaria, Marincheva Viktoria ,   University of Forestry-Sofia, Faculty of Veterinary Medicine, 10 Kliment Ohridski Blvd., Sofia 1797 Bulgaria, Marinova Mina-Maria ,   University of Forestry-Sofia, Faculty of Veterinary Medicine, 10 Kliment Ohridski Blvd., Sofia 1797 Bulgaria
Published: February 2025

Infrared thermography is an increasingly popular diagnostic method in equine veterinary medicine,
while its application in donkeys remains relatively limited. The aim of this study was to determine the surface
body temperature of six clinically healthy female donkeys of the breed Balkan donkey. The donkeys` bodies were
divided into the following regions: neck, shoulder, thoracic limb, back, thigh and pelvic limb and were laterally
scanned on both the left and right sides. Only the abdomens of the donkeys were scanned individually from the
ventral side of the body. The mean surface temperature of each region was calculated revealing approximately
bilateral thermal symmetry in the donkeys‘ bodies. Similar studies may be useful for donkey health and welfare
given the renewed interest in donkeys as milking and companion animals.
Desarrollo de una metodología para selección de variables de entrenamiento de una CNN para identificar el modelo dinámico de un cuadrotor
Authors:   Colegio Nacional de Educación Profesional Técnica, Valenzuela Hernández José de Jesús , Mora Castro Giovanni ,   Colegio Nacional de Educación Profesional Técnica, Bojórquez Delgado Gilberto ,   Instituto Tecnológico Superior de Guasave
Published: February 2025

El presente artículo, explora el uso de redes neuronales convolucionales (CNN) para modelar la dinámica no lineal de cuadricópteros utilizando datos de vuelo registrados en la “caja negra”. Este enfoque es crucial debido a la complejidad y la naturaleza no lineal de los cuadricópteros, que demandan métodos avanzados de modelización. La investigación se centra en seleccionar las variables más significativas para el entrenamiento de la CNN, con el objetivo de mejorar la adaptabilidad y eficiencia de los drones en entornos dinámicos y no estructurados.
Selección y evaluación de modelos de inteligencia artificial para la detección de maleza en cultivos agrícolas
Authors:   Universidad Autónoma de Sinaloa, Ayala Cruz Karla Vanessa , Valenzuela Hernández José de Jesús ,   Colegio Nacional de Educación Profesional Técnica, Bojórquez Delgado Gilberto ,   Instituto Tecnológico Superior de Guasave
Published: February 2025

Los retos en la agricultura moderna cada vez más complejos y requieren de soluciones más avanzadas en el campo de las tecnologías aplicadas. Uno de los retos más importantes en el campo de la agricultura es la detección y control de malezas, ya que la presencia de ellas presenta pérdidas significativas en el rendimiento proyectado desde la programación del cultivo. El artículo aborda la necesidad de utilizar modelos avanzados de IA para mejorar la gestión de malezas en cultivos de maíz mediante el uso de drones. Se llevó a cabo una revisión sistemática de la literatura para identificar y evaluar los modelos de IA más relevantes: YOLO, Faster R-CNN, ResNet y VGG. El método de análisis fue la revisión sistemática de bibliografía la cual se dividió en tres pasos. Primero, se recopiló bibliografía sobre cada modelo mediante búsquedas exhaustivas en bases de datos académicas como IEEE Xplore, Google Scholar y ScienceDirect.
Public Perception Regarding Paternity Leave Rights During Childbirth
Authors: Rahman Adtiya , Hadi Mukhammad Nur
Published: February 2025

Paternity leave is important in realizing gender equality and family well-being. This article aims to analyze the public perception of the paternity leave policy and its implications in supporting the wife's childbirth process. A phenomenological and normative juridical approach was used in the preparation of this article, by selecting 6 (six) male informants living in the city of Surabaya, East Java. The results of the study show that the duration of 2-3 days of leave regulated in the laws and regulations in Indonesia is considered sufficient for accompanying the wife during childbirth and postpartum. Patriarchal cultural norms are considered the main cause of hindering co-parenting. The husband must be able to play an important and active role as part of the responsibility for the welfare and harmony of the family. Paternity leave stipulated by laws and regulations in Indonesia is expected to be able to provide space for fathers to learn and develop skills in parenting, to be able to foster a sense of responsibility.  The state seeks to provide a transition impetus from a lack of fatherhood to one based on cultural recognition. Further research is needed to explore the effectiveness of these policies in a variety of social contexts
A Rare Case of Recurrence of Bilateral Corneal Edema Secondary to Amantadine
Authors: Singh Dipti , Wentworth Gregg
Published: February 2025

This case demonstrates the role of a thorough patient history in the early diagnosis of corneal edema secondary to amantadine. The ophthalmic adverse effects are uncommon but well documented.
PHOTO ESSAY: Management of Penetrating Injuries and Intraocular Foreign Bodies
Authors: Kellogg Kelly Allicia , Natarajan Ramya
Published: February 2025

Intraocular foreign bodies (IOFBs) are one of the most common causes of ophthalmologic emergencies and are most often metallic. Foreign bodies are...