bluuebunny/crossref_metadata_2025 huggingface dataset:
A modified Imhäuser osteotomy
Authors: Bali N. S. , Harrison J. O. , Bache C. E.
Published: August 2014

The aim of this study was to determine whether an osteoplasty of the femoral neck performed at the same time as an intertrochanteric Imhäuser osteotomy led to an improved functional outcome or increased morbidity. A total of 20 hips in 19 patients (12 left, 8 right, 13 male, 6 female), who underwent an Imhäuser intertrochanteric osteotomy following a slipped capital femoral epiphysis were assessed over an eight-year period. A total of 13 hips in 13 patients had an osteoplasty of the femoral neck at the same time. The remaining six patients (seven hips) had intertrochanteric osteotomy alone. The mean age was 15.3 years (13 to 20) with a mean follow-up of 57.8 months (15 to 117); 19 of the slips were severe (Southwick grade III) and one was moderate (grade II), with a mean slip angle of 65.3° (50° to 80°); 17 of the slips were stable and three unstable at initial presentation. The mean Non-Arthritic Hip Scores (NAHS) in patients who underwent osteoplasty was 91.7 (76.3 to 100) and the mean NAHS in patients who did not undergo osteoplasty was 76.6 (41.3 to 100) (p = 0.056). Two patients required a subsequent arthroplasty and neither of these patients had an osteoplasty. No hips developed osteonecrosis or chondrolysis, and there was no increase in complications related to the osteoplasty. We recommend that for patients with a slipped upper femoral epiphysis undergoing an intertrochanteric osteotomy, the addition of an osteoplasty of the femoral neck should be considered.

Cite this article: Bone Joint J 2014;96-B:1119–23.
New Connectors Coming for Enteral Feeding Tubes; Marqibo and Risk of Errors; Angeliq is Not a Birth Control Pill
Authors: Cohen Michael R. , Smetzer Judy L.
Published: August 2014

These medication errors have occurred in health care facilities at least once. They will happen again—perhaps where you work. Through education and alertness of personnel and procedural safeguards, they can be avoided. You should consider publishing accounts of errors in your newsletters and/or presenting them at your inservice training programs.

Your assistance is required to continue this feature. The reports described here were received through the Institute for Safe Medication Practices (ISMP) Medication Errors Reporting Program. Any reports published by ISMP will be anonymous. Comments are also invited; the writers' names will be published if desired. ISMP may be contacted at the address shown below.

Errors, close calls, or hazardous conditions may be reported directly to ISMP through the ISMP Web site ( www.ismp.org ), by calling 800-FAIL-SAFE, or via e-mail at ismpinfo@ismp.org . ISMP guarantees the confidentiality and security of the information received and respects reporters' wishes as to the level of detail included in publications.
Mathematical Modeling to Reduce Waste of Compounded Sterile Products in Hospital Pharmacies
Authors: Tilson Vera , Dobson Gregory , Haas Curtis E. , Tilson David
Published: August 2014

In recent years, many US hospitals embarked on “lean” projects to reduce waste. One advantage of the lean operational improvement methodology is that it relies on process observation by those engaged in the work and requires relatively little data. However, the thoughtful analysis of the data captured by operational systems allows the modeling of many potential process options. Such models permit the evaluation of likely waste reductions and financial savings before actual process changes are made. Thus the most promising options can be identified prospectively, change efforts targeted accordingly, and realistic targets set. This article provides one example of such a data-driven process redesign project focusing on waste reduction in an in-hospital pharmacy. A mathematical model of the medication prepared and delivered by the pharmacy is used to estimate the savings from several potential redesign options (rescheduling the start of production, scheduling multiple batches, or reordering production within a batch) as well as the impact of information system enhancements. The key finding is that mathematical modeling can indeed be a useful tool. In one hospital setting, it estimated that waste could be realistically reduced by around 50% by using several process changes and that the greatest benefit would be gained by rescheduling the start of production (for a single batch) away from the period when most order cancellations are made.
Galactokinase Is a Novel Modifier of Calcineurin-Induced Cardiomyopathy in Drosophila
Authors: Lee Teresa E , Yu Lin , Wolf Matthew J , Rockman Howard A
Published: August 2014

Activated/uninhibited calcineurin is both necessary and sufficient to induce cardiac hypertrophy, a condition that often leads to dilated cardiomyopathy, heart failure, and sudden cardiac death. We expressed constitutively active calcineurin in the adult heart of Drosophila melanogaster and identified enlarged cardiac chamber dimensions and reduced cardiac contractility. In addition, expressing constitutively active calcineurin in the fly heart using the Gal4/UAS system induced an increase in heart wall thickness. We performed a targeted genetic screen for modifiers of calcineurin-induced cardiac enlargement based on previous calcineurin studies in the fly and identified galactokinase as a novel modifier of calcineurin-induced cardiomyopathy. Genomic deficiencies spanning the galactokinase locus, transposable elements that disrupt galactokinase, and cardiac-specific RNAi knockdown of galactokinase suppressed constitutively active calcineurin-induced cardiomyopathy. In addition, in flies expressing constitutively active calcineurin using the Gal4/UAS system, a transposable element in galactokinase suppressed the increase in heart wall thickness. Finally, genetic disruption of galactokinase suppressed calcineurin-induced wing vein abnormalities. Collectively, we generated a model for discovering novel modifiers of calcineurin-induced cardiac enlargement in the fly and identified galactokinase as a previously unknown regulator of calcineurin-induced cardiomyopathy in adult Drosophila.
Co-construction of turns at talk
Authors: Lind Marianne , Sønsterud Hilda
Published: August 2014

The present study applies conversation analysis in order to describe the form and function of co-constructed turns in conversations involving one or more persons who stutter. Co-constructed turns are turns at talk that are produced by more than one speaker in such a way that the turn is initiated by one speaker and completed by another. Examples in the data are classified according to an existing taxonomy distinguishing between slot fillers, extensions and completions. All these types are found in our data, albeit to different extents. External as well as internal reasons for this distributional variation are discussed. The main aim of the study is to illustrate the need for qualitative, context-sensitive approaches to research on verbal interaction in the field of fluency disorders and to focus on some clinical implications of such research findings.
The nature, extent, and ecological implications of marine light pollution
Authors: Davies Thomas W , Duffy James P , Bennie Jon , Gaston Kevin J
Published: August 2014

Despite centuries of use, artificial light at night has only recently been recognized as a cause for environmental concern. Its global extent and ongoing encroachment into naturally lit ecosystems has sparked scientific interest into the many ways in which it may negatively affect human health, societal attitudes, scientific endeavors, and biological processes. Yet, perhaps because sources of artificial light are largely land based, the potential for artificial light pollution to interfere with the biology of the ocean has not been explored in any detail. There is little information on how light pollution affects those species, behaviors, and interactions that are informed by the intensity, spectra, and periodicity of natural nighttime light in marine ecosystems. Here, we provide an overview of the extent of marine light pollution, discuss how it changes the physical environment, and explore its potential role in shaping marine ecosystems.
Accurate Measurements of Liquid-Condensate Rate With Multiphase-Metering Technology Improve Ecological Impact of Well Test in Deepwater Well Offshore Brazil
Authors: Maizeret Pierre-David , Reid David , Theuveny Bertrand
Published: August 2014

Separators have a proven track record and are widely used in well-testing operations. However, their range of applications is relatively narrow, and they can encounter limitations with fluids for which separation quality is an issue.

This paper describes a well test in a deepwater well offshore Brazil. To be able to accommodate different production scenarios, two separators and a multiphase meter were used to measure the flow rates. During the test, a comparison of the flow rates from the multiphase flowmeter and those reported by the separator made possible the identification of some carry-over in the separator at a high choke setting. When the choke size was increased, the separator gas rate increased, whereas the liquid rate dropped at the separator, resulting in a very low condensate/gas ratio (CGR). The multiphase meter, on the other hand, reported a constant CGR, allowing for the real-time diagnostic that carry-over was occurring at the separator. At the end of the test, the same increased choke setting was used for a short period of time to confirm the behavior. The same rate results were observed for each phase, and a small amount of liquid could be seen in the gas flare. The final proof came from the analysis of the downhole samples, which confirmed the CGR measured with the multiphase meter.

The consistent results from the multiphase meter make the meter ideal to validate the flow-rate measurements from the reservoir and to improve the burning efficiency. By allowing early identification of imperfect separation, the multiphase meter reduces the health, safety, and environmental (HSE) risks associated with well-test operations.
Well Recovery, Drainage Area, and Future Drill-Well Inventory: Empirical Study of the Barnett Shale Gas Play
Authors: Ikonnikova S.. , Browning J.. , Horvath S.. , Tinker S.W.. W.
Published: August 2014

The work is focused on one of the oldest and largest developed shale-gas plays—the Barnett shale. The primary objective is to bring more clarity and granularity to the Barnett resource estimation. The second task is to develop a resource-estimation methodology that one can use to evaluate other shale-gas plays in an attempt to determine their potential for development.

We compile a comprehensive database, including production histories of more than 16,000 drilled wells and calibrated density log porosity and net-pay-zone-thickness maps. The data are used to estimate (1) the remaining technically recoverable free-gas resource, (2) individual-well recoveries, (3) areas drained by the existing wells, and (4) the future drill-well inventory. On the basis of the geographical distribution of individual-well estimated ultimate recoveries, we divide the Barnett acreage into 10 tiers. We describe the future drill-well inventory for each tier.

In addition, to assess the potential contribution of refracturing to the future Barnett production, we develop a statistical procedure to identify wells that are likely to be refractured and then analyze their performances.
Alfalfa Stand Length and Subsequent Crop Patterns in the Upper Midwestern United States
Authors: Yost Matt A. , Russelle Michael P. , Coulter Jeffrey A. , Bolstad Paul V.
Published: August 2014

Alfalfa (Medicago sativa L.) can provide many economic and environmental benefits to crop rotations. Our objectives were to quantify alfalfa stand lengths, identify the two crops following alfalfa, and determine the soil and temporal factors affecting them. The USDA‐National Agricultural Statistics Service (NASS) Cropland Data Layers (CDLs) for 2006 to 2012 and USDA‐NRCS soil survey layers for North Dakota, South Dakota, Nebraska, Minnesota, Iowa, and Wisconsin were combined and used to meet these objectives. Location and soil textural class generally determined stand length, with alfalfa being kept in production longer outside the major Corn Belt area of this region. Soil textural class effects on stand length varied by state. Corn (Zea mays L.) was the most common crop planted during the first‐ and second‐year following alfalfa (79 and 61%, respectively), except in North Dakota (35% both years). Soybean [Glycine max (L.) Merr.] was grown in 11 and 28% of cases, respectively. Small grains were planted as the first‐year crop in 29% of cases in the Dakotas and 6% of cases in the other four states. As a second‐year crop, small grains occurred in 26% of cases in North Dakota and 5% of cases in the other five states. Stand length, soil textural class, state, and year significantly influenced grower choice of both following crops. These geographic assessments will guide research and extension education designed to increase use of perennials for economic and environmental benefits. Similar methods can be applied to other crop rotations or U.S. regions.
Planting Density and Irrigation Timing Affects Cleistogenes songorica Seed Yield Sustainability
Authors: Li Xin Yong , Wang Yan Rong , Wei Xue , Tai Jian Hui , Jia Cun Zhi , Hu Xiao Wen , Trethewey Jason A.K.
Published: August 2014

Native grasses play an important role in the sustainable development of grassland animal husbandry, land protection, and the lawn industry. However, with seed yields often low and variable, it is necessary to develop techniques for increasing seed production in these species. From 2007 to 2012, field trials using nine planting densities (5, 10, 15, 20, 25, 30, 35, 40, and 50 plants m−2) were conducted in an arid region of China. The effect of planting density on seed yield and its components was investigated for a drought‐tolerant grass species, Cleistogenes songorica (Roshev.) Ohwi. Seed yield persistence and yield response to seasonal rainfall during the trials were also examined. The highest seed yield was obtained at 30 plants m−2, with a mean seed yield of 500 kg ha−1 over the 6 yr. Among seed yield components, the number of fertile tillers m−2 had the greatest influence on seed yield. The percentage of actual seed yield vs. potential seed yield was 40 to 47%. There was a positive correlation between seed yield and precipitation during heading and flowering stages. The present study showed that C. songorica can be used in seed production for at least six consecutive harvests. Irrigation during the heading and flowering stages may be used to increase the seed yield of C. songorica.
Dual Cropping Winter Camelina with Soybean in the Northern Corn Belt
Authors: Gesch R. W. , Archer D. W. , Berti M. T.
Published: August 2014

Sustainably balancing biofuel crop production with food, feed, and fiber on agricultural lands will require developing new cropping strategies. Double‐ and/or relay‐cropping winter camelina (Camelina sativaL.) with soybean [Glycine max(L.) Merr.] may be a means to produce an energy and food crop on the same land in a single year. A study was conducted between 2009 and 2011 in west central Minnesota to evaluate yields, seed quality, economics, and within‐field energy balance of winter camelina–soybean double‐ and relay‐cropping systems compared with a conventional monocropped full‐season soybean. Systems included methods to hasten camelina harvest (e.g., swathing and desiccating) to promote early soybean growth. Camelina seed yields were unaffected by cropping system and ranged from 1.1 to 1.3 Mg ha−1. Relay‐cropped soybean yields were greater than double‐cropped soybean and were 58 to 83% of that for the monocropped control. Seed oil and protein content of double‐ and relay‐cropped soybean were comparable to their monocropped counterpart and combined seed oil yield for the dual crop systems was as much as 50% greater. Net economic returns for the relay‐crop treatments were competitive with that of the full‐season soybean. Moreover, net energy of the relay‐crop treatments was generally as high as the sole soybean crop, but energy efficiency (outputs/inputs) was less due to greater inputs. Results indicate that dual cropping of winter camelina with soybean is agronomically viable for the upper Midwest and might be an attractive system to growers seeking a “cash” cover crop.
An Integrative Review and Synthesis of XBRL Research in Academic Journals
Authors: Perdana Arif , Robb Alastair , Rohde Fiona
Published: August 2014

Extensible business reporting language (XBRL) was developed from an established markup computer language (eXtensible Markup Language, XML). XBRL facilitates data and information exchange between different information systems (IS). This important feature has attracted much research since the early 2000s. This article aims to provide a framework for XBRL research's contributions to information systems (IS). An integrative review is needed to draw an overall picture and canvas key findings regarding the various XBRL topics examined in past studies. Such a review also identifies research opportunities and guides future XBRL research. We conducted thematic analysis using an integrative literature review. A sample of 150 XBRL articles obtained from various peer-reviewed academic journals was used to understand past XBRL studies and suggest XBRL's future research direction. This article identifies and proposes four current XBRL research streams; namely, XBRL's impact on business, XBRL's adoption, XBRL's technical development, and XBRL education. This paper then examines the key findings of these XBRL papers, offers several potential areas where further investigation may be warranted, and suggests XBRL research-informed practices.
Wear Properties of a Novel Resin Composite Compared to Human Enamel and Other Restorative Materials
Authors: D'Arcangelo C , Vanini L , Rondoni GD , Pirani M , Vadini M , Gattone M , De Angelis F
Published: August 2014

The purpose of this in vitro study was to compare the two-body wear resistance of human enamel, a pressable glass-ceramic (Imagine PressX), a type 3 gold alloy (Aurocast8), three resins composites currently available on the market (Enamel plus HRi, Filtek Supreme XTE, Ceram.X duo), and one recently introduced resin composite (Enamel plus HRi-Function). Resin composites were tested after simple light curing and after a further heat polymerization cycle. Ten cylindrical specimens (7 mm in diameter) were manufactured with each dental material according to standard laboratory procedures. Ten flat enamel specimens were obtained from freshly extracted human molars and included in the control group. All samples were subjected to a two-body wear test in a dual-axis chewing simulator over up to 120,000 loading cycles, against yttria stabilized tetragonal zirconia polycrystal cusps. Wear resistance was analyzed by measuring the vertical substance loss (mm) and the volume loss (mm3). Antagonist wear (mm) was also recorded. Data were statistically analyzed using one-way analysis of variance (ANOVA) (wear depth and volume loss) and Kruskal-Wallis one-way ANOVA on ranks (antagonist wear). Heat-cured HRi function and Aurocast8 showed similar mean values for wear depth and volumetric loss, and their results did not statistically differ in comparison with the human enamel.
Influence of a Repeated Preheating Procedure on Mechanical Properties of Three Resin Composites
Authors: D'Amario M , De Angelis F , Vadini M , Marchili N , Mummolo S , D'Arcangelo C
Published: August 2014

The aim of this study was to assess the flexural strength, flexural elastic modulus and Vickers microhardness of three resin composites prepared at room temperature or cured after one or repeated preheating cycles to a temperature of 39°C. Three resin composites were evaluated: Enamel Plus HFO (Micerium), Opallis (FGM), and Ceram X Duo (Dentsply DeTrey). For each trial, one group of specimens of each material was fabricated under ambient laboratory conditions, whereas in the other groups, the composites were cured after 1, 10, 20, 30, or 40 preheating cycles to a temperature of 39°C in a preheating device. Ten rectangular prismatic specimens (25 × 2 × 2 mm) were prepared for each group (N=180; n=10) and subjected to a three-point bending test for flexural strength and flexural modulus evaluation. Vickers microhardness was assessed on 10 cylindrical specimens from each group (N=180; n=10). Statistical analysis showed that, regardless of the material, the number of heating cycles was not a significant factor and was unable to influence the three mechanical properties tested. However, a significant main effect of the employed material on the marginal means of the three dependent variables was detected.
Effects of Multipurpose, Universal Adhesives on Resin Bonding to Zirconia Ceramic
Authors: Kim J-H , Chae S-Y , Lee Y , Han G-J , Cho B-H
Published: August 2014

This study evaluated the effects of single-bottle, multipurpose, universal adhesives on the bond strength of resin cement to zirconia ceramic. Polished zirconia ceramic (Cercon base) discs were randomly divided into four groups (n=40) according to the applied surface-conditioning agent: Single Bond 2, Single Bond Universal, All-Bond Universal, and Alloy Primer. Cured composite cylinders (Ø 0.8 mm × 1 mm) were cemented to the conditioned zirconia specimens with resin cement (RelyX ARC). The bonded specimens were subjected to a microshear bond-strength test after 24 hours of water storage and after 10,000 cycles of thermocycling. The surface-conditioning agent significantly influenced the bond strength (p<0.05). Single Bond Universal showed the highest initial bond strength (37.7 ± 5.1 MPa), followed by All-Bond Universal (31.3 ± 5.6 MPa), Alloy Primer (26.9 ± 5.1 MPa), and Single Bond 2 (8.5 ± 4.6 MPa). Artificial aging significantly reduced the bond strengths of all the test groups (p<0.05). After 10,000 cycles of thermocycling, All-Bond Universal showed the highest bond-strength value (26.9 ± 6.4 MPa). Regardless of artificial aging, Single Bond Universal and All-Bond Universal showed significantly higher bond strengths than Alloy Primer, a conventional metal primer.
Effectiveness of Exercise Therapy in Treatment of Patients With Patellofemoral Pain Syndrome: Systematic Review and Meta-Analysis
Authors: Clijsen Ron , Fuchs Janine , Taeymans Jan
Published: August 2014

Background and Purpose

This systematic review and meta-analysis was accomplished to determine whether exercise therapy is an effective intervention to reduce pain and patient-reported measures of activity limitations and participation restrictions (PRMALP) in patients with patellofemoral pain.

Data Sources and Study Selection

Randomized controlled trials in English and German languages published in the MEDLINE, Physiotherapy Evidence Database (PEDro), International Clinical Trials Registry Platform, and Cochrane databases were searched. Eligibility was assessed in 2 stages. The methodological quality of the studies was rated using the PEDro scale. Data were pooled using random-effects meta-analysis, allowing for variability among studies. For clinical use, overall estimates were re-expressed in the original visual analog scale scores. Significance was set at 5%.

Data Extraction and Data Synthesis

Fifteen studies, with a total of 748 participants, were included and pooled for the meta-analysis. Six studies compared the effect of exercise therapy with a control group receiving neither exercise therapy nor another intervention. Four studies compared the effect of exercise therapy versus additive therapy, and 5 studies compared different exercise interventions. In both comparisons, exercise therapy resulted in strong pain reduction and improvement of PRMALP effects. Significant short-term effects (≤12 weeks) of exercise therapy were found for pain and PRMALP, whereas long-term effects (≥26 weeks) were observed for PRMALP only.

Limitations and Conclusion

The 15 studies included in this analysis were of variable quality. Large-scale, high-quality randomized controlled trials are needed to further the evaluation of the possible effects of different exercise therapy modalities on patellofemoral pain. This meta-analysis presents evidence that exercise therapy has a strong pain-reducing effect and decreases PRMALP in patients with patellofemoral pain. However, the question of which exercise modality yields the strongest reducing effect on pain and PRMALP remains unanswered.
Integrating Spanish Language Training Across a Doctor of Physical Therapy Curriculum: A Case Report of One Program’s Evolving Model
Authors: Pechak Celia , Diaz Deborah , Dillon Loretta
Published: August 2014

Background and Purpose

As the Hispanic population continues to expand in the United States, health professionals increasingly may encounter people who speak Spanish and have limited English proficiency. Responding to these changes, various health profession educators have incorporated Spanish language training into their curricula. Of 12 doctor of physical therapy (DPT) programs identified as including elective or required Spanish courses, the program at The University of Texas at El Paso is the only one integrating required Spanish language training across the curriculum. The purpose of this case report is to describe the development, implementation, and preliminary outcomes of the evolving educational model at The University of Texas at El Paso.

Case Description

The University of Texas at El Paso is situated immediately across the border from Mexico. Responding to the large population with limited English proficiency in the community, faculty began to integrate required Spanish language training during a transition from a master-level to a DPT curriculum. The Spanish language curriculum pillar includes a Spanish medical terminology course, language learning opportunities threaded throughout the clinical courses, clinical education courses, and service-learning. Forty-five DPT students have completed the curriculum.

Outcomes

Assessment methods were limited for early cohorts. Clinically relevant Spanish verbal proficiency was assessed with a practical examination in the Spanish course, a clinical instructor–rated instrument, and student feedback. Preliminary data suggested that the model is improving Spanish language proficiency.

Discussion

The model still is evolving. Spanish language learning opportunities in the curriculum are being expanded. Also, problems with the clinical outcome measure have been recognized. Better definition of intended outcomes and validation of a revised tool are needed. This report should promote opportunities for collaboration with others who are interested in linguistic competence.
No evidence of transmission from an acute case of hepatitis A in a foodhandler: follow-up of almost 1,000 potentially exposed individuals, London, United Kingdom, April 2012
Authors: Hall V , Abrahams A , Turbitt D , Cathcart S , Maguire H , Balasegaram S
Published: August 2014

Identification of acute hepatitis A virus (HAV) infection in a foodhandler in a London hotel led to a large incident response. We identified three potentially exposed groups: hotel staff who had regularly consumed food prepared by the case and shared toilet facilities with the case, patients who shared the same hospital ward as the case and hotel guests who consumed food prepared by the case. We arranged post-exposure HAV vaccination for all 83 potentially exposed hotel staff and all 17 patients. We emailed 887 guests advising them to seek medical care if symptomatic, but did not advise vaccination as it was too late to be effective for most guests. Through the International Health Regulations national focal points and the European Union Early warning and response system (EWRS), we communicated the details of the incident to public health agencies and potential risk of HAV transmission to international guests. Potentially exposed hotel staff and guests were asked to complete an online or telephone-administered questionnaire 50 days following possible exposure, to identify any secondary cases. Survey response was low, with 155 responses from guests and 33 from hotel staff. We identified no secondary cases of HAV infection through follow-up.
Trophic Effects and Regenerative Potential of Mobilized Mesenchymal Stem Cells from Bone Marrow and Adipose Tissue as Alternative Cell Sources for Pulp/Dentin Regeneration
Authors: Murakami Masashi , Hayashi Yuki , Iohara Koichiro , Osako Yohei , Hirose Yujiro , Nakashima Misako
Published: August 2014

Dental pulp stem cell (DPSC) subsets mobilized by granulocyte-colony-stimulating factor (G-CSF) are safe and efficacious for complete pulp regeneration. The supply of autologous pulp tissue, however, is very limited in the aged. Therefore, alternative sources of mesenchymal stem/progenitor cells (MSCs) are needed for the cell therapy. In this study, DPSCs, bone marrow (BM), and adipose tissue (AD)-derived stem cells of the same individual dog were isolated using G-CSF-induced mobilization (MDPSCs, MBMSCs, and MADSCs). The positive rates of CXCR4 and G-CSFR in MDPSCs were similar to MADSCs and were significantly higher than those in MBMSCs. Trophic effects of MDPSCs on angiogenesis, neurite extension, migration, and anti-apoptosis were higher than those of MBMSCs and MADSCs. Pulp-like loose connective tissues were regenerated in all three MSC transplantations. Significantly higher volume of regenerated pulp and higher density of vascularization and innervation were observed in response to MDPSCs compared to MBMSC and MADSC transplantation. Collagenous matrix containing dentin sialophosphoprotein ( DSPP)-positive odontoblast-like cells was the highest in MBMSCs and significantly higher in MADSCs compared to MDPSCs. MBMSCs and MADSCs, therefore, have potential for pulp regeneration, although the volume of regenerated pulp tissue, angiogenesis, and reinnervation, were less. Thus, in conclusion, an alternative cell source for dental pulp/dentin regeneration are stem cells from BM and AD tissue.
A Pilot Study Examining the Effects of Tolvaptan on Residual Renal Function in Peritoneal Dialysis for Diabetics
Authors: Hiramatsu Takeyuki , Hobo Akinori , Hayasaki Takahiro , Kabu Koki , Furuta Shinji
Published: August 2014

Background

For patients with end-stage renal disease (ESRD), peritoneal dialysis (PD) serves as a possible renal replacement therapy. However, most PD patients, particularly those with ESRD and diabetes mellitus, reportedly discontinue PD early, resulting in shorter survival periods and poorer prognosis because of overhydration. Recently, the vasopressin-2 receptor antagonist tolvaptan was approved for volume control in patients with heart failure. The present study aimed to identify the effects of tolvaptan in diabetic PD patients.

Methods

In this pilot study, the tolvaptan group ( n = 12) were treated with 15 mg/day of tolvaptan 2 weeks after PD initiation and were prospectively analyzed for 1 year, and patients in the control group ( n = 12) did not receive tolvaptan and were retrospectively analyzed for 1 year. In addition to the biochemical tests, echocardiograms, serum atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) levels, peritoneal Kt/V, and creatinine clearance (CCr) were examined at baseline and at 6 and 12 months after PD initiation.

Results

In the control group, the urine volume, renal Kt/V, and renal CCr levels consistently decreased; however, these parameters were stably maintained during the study period in the tolvaptan group. Atrial natriuretic peptide, CRP levels and the left ventricular mass index of the tolvaptan-treated group were significantly lower than those in the control group, whereas total protein and albumin levels were significantly higher at 6 and 12 months in the tolvaptan group. There were no obvious adverse effects.

Conclusions

These data suggest that tolvaptan may preserve residual renal function and improve volume control in PD patients with diabetes mellitus.
Improving the Evidence Base of Nursing Education Programs
Authors: Lubejko Barbara G.
Published: August 2014

The need for evidence-based practice (EBP) has been supported by many professional groups. However, nurses face many barriers to involvement in the EBP process. Continuing nursing education program planners can play a key role in helping to overcome these barriers by working with presenters and content developers to ensure that the content they prepare is rooted in the best available evidence.

J Contin Educ Nurs.
2014;45(8):336–337.
Leading With Simplicity
Authors: Bleich Michael R.
Published: August 2014

The clinical requirements to deliver safe quality care to patients and the human interactions between and among professional disciplines and agencies are extremely complex. Leaders transform complexity into simplicity. Ten laws of simplicity provide a framework for improving care delivery.

J Contin Educ Nurs.
2014;45(8):340–341.
Using Reflective Journaling to Improve the Orientation of Graduate Nurses
Authors: Lepianka Julie Elizabeth
Published: August 2014

Reflective journaling is valuable in improving critical thinking and problem solving in nursing students. Incorporating reflective journaling into the orientation process with new nursing graduates may decrease anxiety during this challenging transition while continuing to improve critical thinking. Engaging graduate nurses in reflective journaling during the orientation process may result in more satisfied, competent nurses overall.

J Contin Educ Nurs.
2014;45(8):342–343.
Endovascular Management of Ureteroarterial Fistula: A Rare Potentially Life Threatening Cause of Hematuria
Authors: Copelan Alexander , Chehab Monzer , Cash Charles , Korman Howard , Dixit Purushottam
Published: August 2014

Ureteroarterial fistula is a rare, potentially life-threatening cause of hematuria characterized by an abnormal channel between a ureter and artery.  The rarity of this condition, complexity of predisposing risk factors and intermittence of symptoms may delay or obscure its diagnosis. With a high index of suspicion and careful angiographic evaluation, embarking on this condition is not only possible but sets the stage for curative intervention. We report a case of a ureteroarterial fistula presenting with intermittent hematuria, successfully diagnosed at angiography and managed with endovascular stent graft placement.
Presentación
Authors: Caro Isaac
Published: August 2014

Presentación
A community perspective of spirit and healing in Africa
Authors: Potgieter Raymond
Published: August 2014

No abstract available
Investigating the Role of Entrepreneurial Leadership and Social Capital in SME Competitiveness in the Food and Drink Industry
Authors: Hunter Lise , Lean Jonathan
Published: August 2014

This paper investigates the effects of social capital on the competitiveness of small and medium-sized enterprises, using entrepreneurial leadership as the explanatory variable. It employs a data set of 359 food and drink manufacturers in the south-west of England to develop a structural equation model of interdependence between social capital, leadership and entrepreneurship. The study reveals that social ties with local associations and professional services providers are predominant on both structural and relational dimensions. The resulting inadequate level of brokerage obstructs the market knowledge required for vision formulation, despite the fact that ‘hard work’, ‘continued improvement’ and ‘ambition’ are common shared values in this sector. The paper concludes by recommending training to fill the knowledge gaps impeding the sector's competitiveness.
Influence of stand density and soil treatment on the Spanish Black Pine (Pinus nigra Arn. ssp. Salzmannii) regeneration in Spain
Authors: Cerro Barja A. del , Lucas Borja M. E. , Martínez García E. , López Serrano F. R. , Andrés Abellán M. , García Morote F. A. , Navarro López R.
Published: August 2014

Satisfactory results relating to the natural regeneration of the Spanish black pine (Pinus nigra Arn ssp. salzmannii) is generally difficult to achieve. The natural regeneration of this pine was studied comparing two types of soil treatment and various overstory densities in six experimental forests. These studies were conducted from 1999 to 2002 and seed rain and germination, as well as seedling survival were observed in a number of specific plots: Brushing, scalping and control plots. In addition various overstory densities were used (measured as base area (square m/ha). Soil and air temperature together with soil moisture were continuously recorded throughout this summer period. The results showed that seed germination was higher in plots using the scalping technique, as opposed to the brushed or controlled plots. The best seedling survival percentage was found in scalped plots together with a larger basal area. It was also found that seedling survival was lower during the first year than during the second one. The results have practical implications for management of Spanish black pine forests as well as valuable information which could improve the conditions for regeneration.
Wood anatomical relationships within Abies spp. from the Mediterranean area: a phyletic approach
Authors: Esteban L. G. , Palacios P. de , García Fernández F. , Martín J. A.
Published: August 2014

An analysis was made of the wood anatomy of seven species, one subspecies and two varieties of the genus Abies from the Mediterranean area (A. alba, A. borisii-regis, A. cephalonica, A. cilicica, A. nordmanniana, A. nordmanniana subsp. equi-trojani, A. numidica, A. pinsapo, A. pinsapo var. marocana and A. pinsapo var. tazaotana) in order to find phyletically relevant features to help clarify and complement the evolutionary patterns based on molecular studies. The wood structure within the genus was qualitatively similar, except for specific features characteristic of certain provenances. However, the wood biometry allowed the different taxa to be grouped in accordance with their anatomical similarity. A. alba, A. pinsapo, A. pinsapo var. marocana and A. pinsapo var. tazaotana possess biometric features which distinguish them from the other Mediterranean firs. Furthermore, A. numidica showed biometric features which distinguish it from the eastern firs (A. borisii-regis, A. cephalonica, A. cilicica, A. nordmanniana and A. nordmanniana subsp. equi-trojani) and place it closer to certain Iberian populations of A. pinsapo. The maximum ray height in number of cells, frequency of rays with more than 30 cells and tracheid length can be regarded as specific patterns of the Mediterranean fir phylum.
Modeling the individual growth of the Gulf corvina, Cynoscion othonopterus (Pisces: Sciaenidae), using a multi-model approach
Authors: Aragon-Noriega E Alberto
Published: August 2014

The Gulf corvina, Cynoscion othonopterus, is an endemic sciaenid of the Upper Gulf of California and Colorado River Delta biosphere reserve. It is a high-value fishery resource in this region. To sustainably manage this resource, it is necessary to address its individual growth pattern. Previous studies on C. othonopterus growth have fitted the von Bertalanffy growth model (VBGM) without examining alternative models. In this study, the main objective was to analyze the individual growth of the Gulf corvina via a multi-model inference (MMI) approach rather than simply applying the VBGM. Five growth models—VBGM, logistic, Gompertz, Schnute, and Schnute–Richards—were tested. The parameters of each model and their confidence intervals (CI) were computed using the maximumlikelihood method. The MMI was used to average the asymptotic length (L∞). The best-fitting model was selected using the Akaike information criterion, and the Schnute–Richards growth model best described the growth of the Gulf corvina. The L∞ values obtained via MMI averaged 735.0 mm (95% CI: 730.4–739.5 mm). The conclusion is that the growth of C. othonopterus exhibits a biphasic pattern that is better described by a higher-parameter model such as the Schnute–Richards model.
The World Needs a Staph Vaccine—New Research Could Bring It a Step Closer
Authors: Coffey Donavyn
Published: August 2024

This Medical News article discusses recent findings that help explain Staphylococcus aureus vaccine failures.
As Ransomware Attacks on Health Care Surge, Here’s What Clinicians and Health Systems Can Do
Authors: Bock Anna
Published: August 2024

This Medical News story discusses the rise in ransomware cyberattacks on health care, as well as new cybersecurity initiatives.
Geometric and dosimetric evaluation for breast and regional nodal auto‐segmentation structures
Authors: Tsui Tiffany , Podgorsak Alexander , Roeske John C. , Small William , Refaat Tamer , Kang Hyejoo
Published: August 2024

The accuracy of artificial intelligence (AI) generated contours for intact‐breast and post‐mastectomy radiotherapy plans was evaluated. Geometric and dosimetric comparisons were performed between auto‐contours (ACs) and manual‐contours (MCs) produced by physicians for target structures.

Breast and regional nodal structures were manually delineated on 66 breast cancer patients. ACs were retrospectively generated. The characteristics of the breast/post‐mastectomy chestwall (CW) and regional nodal structures (axillary [AxN], supraclavicular [SC], internal mammary [IM]) were geometrically evaluated by Dice similarity coefficient (DSC), mean surface distance, and Hausdorff Distance. The structures were also evaluated dosimetrically by superimposing the MC clinically delivered plans onto the ACs to assess the impact of utilizing ACs with target dose (Vx%) evaluation.

Positive geometric correlations between volume and DSC for intact‐breast, AxN, and CW were observed. Little or anti correlations between volume and DSC for IM and SC were shown. For intact‐breast plans, insignificant dosimetric differences between ACs and MCs were observed for AxNV95% (p = 0.17) and SCV95% (p = 0.16), while IMNV90% ACs and MCs were significantly different. The average V95% for intact‐breast MCs (98.4%) and ACs (97.1%) were comparable but statistically different (p = 0.02). For post‐mastectomy plans, AxNV95% (p = 0.35) and SCV95% (p = 0.08) were consistent between ACs and MCs, while IMNV90% was significantly different. Additionally, 94.1% of AC‐breasts met ΔV95% variation <5% when DSC > 0.7. However, only 62.5% AC‐CWs achieved the same metrics, despite AC‐CWV95% (p = 0.43) being statistically insignificant.

The AC intact‐breast structure was dosimetrically similar to MCs. The AC AxN and SC may require manual adjustments. Careful review should be performed for AC post‐mastectomy CW and IMN before treatment planning. The findings of this study may guide the clinical decision‐making process for the utilization of AI‐driven ACs for intact‐breast and post‐mastectomy plans. Before clinical implementation of this auto‐segmentation software, an in‐depth assessment of agreement with each local facilities MCs is needed.
NSDUH: Nicotine vaping, underage marijuana use, treatment gap prominent
Authors: Knopf Alison
Published: August 2024

Last year, 5.9 million people initiated vaping nicotine — more initiation than of any other substance — according to the National Survey on Drug Use and Health (NSDUH). The results, released last week by the Substance Abuse and Mental Health Services Administration (SAMHSA), also show that 9.4% of people ages 12 or older vaped nicotine in the past month, which is up from 8.3% in 2022. Also, people under age 21 are using marijuana even more than alcohol on a regular basis despite it being illegal.
Stimulation‐Reinforced Cellulose–Protein Ionogels with Superior Mechanical Strength and Temperature Resistance
Authors: Li Xin , Jiang Haibo , Zhang Yang , Long Qian , Jiang Geyuan , Zeng Suqing , Zhou Jianfei , Zhao Dawei
Published: August 2024

Ionogels, recognized for their flexibility and ionic conductivity, show considerable promise across various applications including electronic skins, biomedical electronics, and smart robotics. However, the majority of ionogels are plagued by suboptimal mechanical strength, a restricted range of operating temperatures, and poor recyclability. Here, an acetone‐stimulated supramolecular reinforcement strategy to develop robust and environmentally tolerant ionogels is introduced. The bio‐based ionogels feature a firm supramolecular architecture formed by the entwining of soybean protein molecules around cellulose macromolecular chains. This coiled design, inspired by cucumber vines, endows the ionogels with remarkable tensile strength (>30 MPa), enables them to withstand temperature above 85 °C with tensile strength over 15 MPa, and maintains notable cold resistance down to −20 °C with tensile strength exceeding 10 MPa. Further, the bio‐based ionogels exhibit excellent recyclability, reprocessing capabilities, shape customizability, good biocompatibility, and full biodegradability. This study provides a valuable strategy for manipulating supramolecular conformation to create robust ionogels that overcome the traditional trade‐offs of high strength and environmental tolerance.
Triboelectric Nanogenerators Using Recycled Disposable Medical Masks for Water Wave Energy Harvesting
Authors: Liang Xi , Liu Zhirong , Han Kai , Liu Shijie , Xie Yaxuan , Jiang Tao , Wang Zhong Lin
Published: August 2024

In the current daily life of people, the usage for disposable medical masks (DMMs) continues to be high. Discarded DMMs eventually become plastic pollution, threatening the marine environment seriously. At present, the common plastic recycling methods are extensive and not completely applicable for DMM recycling. In this work, according to the special structural and material characteristics of DMMs, a simple and effective recycling solution is proposed based on triboelectric nanogenerators (TENGs). First, a pulsed electric field system is designed and fabricated to treat the recycled films. The sterilizing rate reaches 91.8%, and the film surface potential is enhanced at the same time. Then, the feasibility of the treated films to be applied as the friction layers of TENGs is verified. Moreover, the recycled films are upgraded by chemical and physical methods, improving the output current of the basic TENG by 3.28 times. Finally, a complete TENG device is constructed to harvest water wave energy, 93.75% of which is made from recycled DMM materials. Under water waves, the power density of 18.22 W m−3 is achieved. Starting from TENG technology, this study combines circular economy and clean energy development, which is of significance for carbon neutralization.
Microrobots Enhancing Synthetic Chemistry Reactions in Non‐Aqueous Media
Authors: Jancik‐Prochazkova Anna , Jancik Jan , Palacios‐Corella Mario , Pumera Martin
Published: August 2024

Catalysis is a foundational pillar of modern synthetic chemistry, essential for countless industrial processes. Traditional catalysts are often static, either immobilized or dispersed in fluid media. The innovative concept of catalytic microrobots allows the introduction of self‐propelled and navigable catalyst particles that are engineered for dynamic and customizable catalysis. Catalytic microrobots are microscale devices with the inherent ability to move and swarm, designed to execute complex tasks in diverse environments, including biomedicine, and environmental remediation. Typically confined to aqueous media, their use in synthetic chemical reactions remains largely unexplored. Here, microrobots are presented as adaptable self‐propelled, self‐mixing micro‐catalysts for the Baeyer–Villiger oxidation, a key industrial process. Zeolite microstructures are tailored, outfitted with magnetic nanoparticles to create zeolite‐based microrobots (ZeoBOTs) that are maneuverable in magnetic fields. Uniquely, these ZeoBOTs are not limited to water but can operate in organic solvents, facilitating the Baeyer–Villiger oxidation in non‐aqueous conditions. Comparative analysis with static ZeoBOTs reveals that the dynamic, “on‐the‐fly” movement of the microrobots significantly enhances reaction yields. The findings herald a new era for synthetic chemistry, demonstrating the potential of microrobots as versatile catalysts beyond aqueous systems, and setting the stage for their broader application in synthetic processes.