bluuebunny/crossref_metadata_2025 huggingface dataset:
QUALITY EVALUATION OF BIOSIMILAR MEDICINES: AN OVERVIEW
Authors: KORKMAZ Emrah , ÖZDEMİRHAN Mehmet Emre , YAPAR Evren ALGIN
Published: May 2020

Biosimilar medicines are biotherapeutics that are similar in quality, safety and efficacy to previously licensed reference biotherapeutics. The slightest change in any stage of production can cause differences in the product. Among the factors, affecting production can be listed as; host cell selection, fermenter type, ambient conditions, broth, substances used for cell culture, fermentation method and purification method. The similarity should be demonstrated by comparative quality, non-clinical and clinical tests. Research and development studies in the biopharmaceutical field bring diversity of quality control methods along with the formulation and manufacturing method of the biosimilars. Although there are some standardized and validated quality control methods given in the internationally recognized pharmacopoeias, there are many in house methods of biopharmaceutical product owners that can only be used as internal quality control methods by them. The main international sources for quality control methods of biopharmaceutics can be given as pharmacopoeias, International Organization for Standardization standards and Organization for Economic Co-operation and Development methods. In this review manufacturing process, regulatory guidelines and quality control of biosimilar medicines briefly are given.
Peer Review History:
Received 11 March 2019; Revised 20 April; Accepted 3 May, Available online 15 May 2020
UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency.
Received file

Average Peer review marks at initial stage: 6.0/10
Average Peer review marks at publication stage: 7.5/10
Reviewer(s) detail:
Name: Dr. Mohamed Salama
Affiliation: Modern University for Technology & Information, Egypt
E-mail: salama47@yahoo.com
 
Name: Dr.  Maha Khalifa Ahmed Khalifa
Affiliation:
E-mail: mahakhalifa.ahmed@hotmail.com
Comments of reviewer(s):
ACORUS CALAMUS L ON TYPE 2 DIABETES MELLITUS MEDICATION
Authors: Najib Ahmad
Published: May 2020

Diabetes is one of the metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. Type 2 diabetes, which accounts for ~90–95% of those with diabetes, the cause is a combination of resistance to insulin action and an inadequate compensatory insulin secretory response. Adequate glycemic control is thus one of the key factors to treat and/or reduce the diabetes and many plants have been used to reduce the glucose level by inhibiting the α-glucosidase that breaks down starch and disaccharides to glucose. Acorus calamus L (AC), a folk medicine to treat type 2 diabetes. In vitro α-glucosidase assay were carried out by measuring the release of p-nitrophenol, the insulin sensitizing activity, AC significantly decreased fasting serum glucose, and suppressed the increase of blood glucose levels after 2g/kg glucose loading in normal mice, in silico study showed that chemical compound on AC can inhibit α-glucosidase and the present study is designed to investigate the effects and molecular mechanisms of AC on glucagon-like peptide-1 (GLP-1) expression and secretion related to its hypoglycemic effects.
Peer Review History:
Received 8 January 2020;   Revised 9 February; Accepted 1 March, Available online 15 March 2020
UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency.
Received file

Average Peer review marks at initial stage: 5.5/10
Average Peer review marks at publication stage: 7.5/10
Reviewer(s) detail:
Name: Dr. Mohamed Said Fathy Al-Refaey
Affiliation: University of Sadat City, Menofia, Egypt
E-mail: mido_ph212@yahoo.com
 
Name: Dr. Gehan Fawzy Abdel Raoof Kandeel
Affiliation: Pharmacognosy Department, National Research Centre, Dokki, 12622,  Giza, Egypt
E-mail: gehankandeel9@yahoo.com
Comments of reviewer(s):

Similar Articles:
PLASMA FERRITIN AND HEPCIDIN LEVELS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS
PHYTOCHEMICAL SCREENING AND IN VITRO ANTIOXIDANT AND ANTI-DIABETIC POTENTIALS OF PERSEA AMERICANA MILL. (LAURACEAE) FRUIT EXTRACT
CRITICAL REVIEW ON BOMBAX CEIBA, ALOE VERA AND XIMENIA AMERICANA
Authors: Mane Rohit Shankar , Vedamurthy Ankala Basappa
Published: May 2020

Therapeutic plants are extensively increased in scenery with their efficient therapeutic properties. India has the greater natural ecosystem from past two decades, near has been a marvelous augment in the applications of natural medicines; though there is still a noteworthy deficiency in the research of medicinal plants and it has the great resources of medicinal plants which are noteworthy to human beings in many ways. The medicinal plants such as Bombax ceiba, Aloe vera and Ximenia Americana are well known to cure several diseases therefore used in different Ayurvedic preparation somehow they are lagging behind in the list of medicinal plants for their applications in drug preparations. These plants has great ethnopharmaceutical and pharmacological properties with therapeutic applications therefore present review gives different aspects of Bombax ceiba, Aloe vera and Ximenia americana and may help to create awareness in society.
Peer Review History:
Received 25 February 2019; Revised 16 April; Accepted 7 May, Available online 15 May 2020
UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency.
Received file

Average Peer review marks at initial stage: 5.0/10
Average Peer review marks at publication stage: 7.0/10
Reviewer(s) detail:
Name: Ahmad Najib
Affiliation: Universitas Muslim Indonesia, Makassar, Indonesia
E-mail: ahmad.najib@umi.ac.id
 
Name: Dr. Mahmut Yıldıztekin
Affiliation: Muğla Sıtkı Koçman University, Turkey
E-mail: mahmutyildiztekin@mu.edu.tr
Comments of reviewer(s):

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A STUDY ON DIFFERENT PLANTS OF APOCYNACEAE FAMILY AND THEIR MEDICINAL USES
A REVIEW ON MEDICINAL USES OF DIFFERENT PLANTS OF EUPHORBIACEAE FAMILY
INTEGRAL PARAMETERS OF CONCRETE DIAGRAMS FOR CALCULATIONS OF STRENGTH OF REINFORCED CONCRETE ELEMENTS USING THE DEFORMATION MODEL
Authors: Eryshev Vladimir , Karpenko Nickolay , Zhemchuyev Artur
Published: May 2020

In accordance with the requirements of regulatory documents, restrictions are introduced on stress levels at the end of the falling branch of the diagrams at the maximum normalized strain values. We have developed mathematical models that establish a uniform sequence for calculating the unambiguous values of deformations at the base points of concrete diagrams, taking into account the accepted functional relationships and the rules for their use according to the tables of normative documents. It was shown that for equal values of deformations and stresses at base points, analytical expressions of diagram recommended by regulatory documents, even if it differs in structure, give identical outlines, diagram branches coincide. The correlation between the calculation models by Russian and foreign regulatory documents was established by comparing the values of the integral parameters of the diagrams and the ultimate forces obtained by calculating the reinforced concrete element according to the deformation model. As integral parameters of concrete deformation diagrams, it was recommended to use areas bounded by diagram branches and diagram completeness coefficients. Analytical modeling of integral parameters allowed us to exclude the procedure for numerically summing stresses along elementary strips in a section and solving nonlinear equations by the method of successive approximations when calculating the strength of an element.
Foreign Policy Strategy of the Fifth Republic: a Timid Turn towards Greater Eurasia
Authors: Zhukov A. D. , Shumilov M. M.
Published: May 2020

The article clarifies the prerequisites and circumstances ofFrancemovement in the direction of selfidentification as a Western economy. Based on an analysis of the foreign policy’s views and practical efforts of theFifthRepublic’s Presidents, the authors note the country's transition from opposing the expansion of partnership withGreat Britainand military cooperation with theUnited Stateswithin the North Atlantic Treaty’s framework to overcoming deep disagreements with NATO to restore membership in its military organization. The “Westernization” ofFrance’s security and defense policies is also explained by its move from national autonomy to understanding the importance of ensuring the country's sovereignty through active participation in European integration. Describing the “proWestern“ course ofFranceat the present stage, the authors pay attention to President E. Macron's skepticism concerning Euro-Atlantic solidarity and the deterioration of the conditions for transatlantic cooperation with theUnited States. According to the authors’ opinion, the current foreign policy strategy ofFranceis distinguished by Eurocentrism, as well as its desire for a strategic partnership with theRussian Federation.
Problems of Russia's Cyber-Security in the Arctic
Authors: Lukin Yu. F.
Published: May 2020

The importance of Arctic natural resources and communications is increasing in the modern global society. At the same time, the Arctic conflict space is not only unprotected from cyberattacks, but their consequences here can be the most terrible in the hybrid war conditions of the XXI century. Cyberattacks on the critical information infrastructure of credit and financial institutions, the economy, authorities and other facilities are becoming especially dangerous. Cybercrimes of hackers for the purpose of obtaining illegal income, threats of money and property loss by the population become more active. The main source of cyberattacks onRussiaare the US Cyber Command, the aggravation risks of cyber warfare between theUSandRussiaare increasing. One of the leaders in protecting against cyberthreats in the Russian Arctic is PJSC MMC Norilsk Nickel.
Optimizing Government Policies On Profession Zakat
Authors: Kasim Nur Mohamad
Published: May 2020

The significant potential of zakat on profession needs to be actualized through a clear regulation. The targets of zakat on profession are: Ministry or State Institutions, Local Government, State-owned Enterprises, Local Government Owned Enterprises, even other professions that have a high income. The government's efforts to facilitate zakat on profession are solely aimed at making the mechanism of zakat management to be good, transparent and integrated into a system. However, zakat levies should have a specific rule that is binding all citizens, especially all Muslim Civil State Apparatus (henceforth called as ASN) who certainly meets the applicable regulations. For those who have income and already reach nishab or nominal income limit must pay zakat, while the ones whose incomes do not reach nishab are not obliged to do such a thing. Gorontalo province is one of the regions whose population is predominantly Muslim and has potential in terms of Islamic values-based economic development. Therefore, there needs to be a strict regulation to regulate zakat on profession, so that the utilization of zakat can help to alleviate the burden of the poor. By the existence of regulation, people who pay and receive zakat are equally having the benefits of zakat. This is to say that government has a prominent role and responsibility in optimizing the enactment of zakat on profession since the reality of the most significant zakat received by BAZNAS (Islamic board which oversees the collection of Zakat) in Gorontalo province is from ASN and other professions income.
Konsepsi Marital Rape dalam Fikih Munakahat
Authors: Syaifuddin Muhammad Irfan
Published: May 2020

Marital rape menjadi kajian penting dalam isu-isu gender dalam beberapa dekade terakhir di Indonesia. Para penggiat kesetaraan gender ­–khususnya feminist – menggambil peran dalam menyuarakan marital rape sebagai bagian kekerasan dalam rumah tangga, yang bagi pelakunya bisa dikenai pidana. Terbitnya UU No. 23 Tahun 2004 tentang Penghapusan Kekerasan Dalam Rumah Tangga (PKDRT) menjadi jawaban terhadap kegelisaan para penggiat HAM khususnya untuk perempuan akan keberpihakan negara dalam melindungi setiap warga yang mendapatkan tindakan kekerasan sekalipun dalam ruang private, yaitu rumah tangga. Jika sebelumnya, kekerasan dalam rumah tangga tidak diatur khusus dalam KUHP dan hanya menjadi delik aduan umum, dalam UU PKDRT diatur dengan jelas dan rigid, marital rape dikategorikan ke dalam kekerasan seksual dan pelakunya dikenai hukuman pidana 12 tahun penjara atau denda sebesar 36 juta rupiah. Namun menjadi ironi jika kita melihat ke dalam litaratur fikih munakahat belum banyak dikemukakan pendapat ahli tentang bagaimana konsep dan hukum marital rape. Maka menumbuhkan kesadaran para ahli fikih akan petingnya konsep marital rape mutlak diperlukan, sehingga bukan hanya berdasar kepada ketentuan dalam hukum positif saja, tapi ketentuan dalam hukum Islam yang tegas terhadap marital rape.
Pengupahan Buruh Panen Padi di Desa Pagersari, Mungkid, Magelang (Analisis Hukum Islam)
Authors: Yanti Aprilia Risma
Published: May 2020

Wage of paddy labors in villages is mostly based on heredity habits. This practice occurs continuously in muamalah activities as in Pagersari village, Mungkid, Magelang. This research aims to analyze the wage of paddy labors in Pagersari village by looking at the condition of the people who do not understand the conformity of the practice with the  Islamic law rules about wage. The method used in this research was descriptive analysis with qualitative approach. The data collection techniques were using interviews, field studies, and documentation studies. Meanwhile the data analysis techniques covered the data reduction, the data presentation, and conclusion drawing. This research was done by people who practice the wage of paddy labors. The result of the research shows that those practices according to Islamic law are categorized in fikih muamalah; that is ijarah based on works (ijarah ala al a’mal) which has been fulfilled the contract basis (rukun akad). The wage received is bawon gabah with the comparison system 12:1, 13:1, and 14:1 from the harvest which is divided between the laborers and the farmers in kilogram units. The wage is categorized ajrul misli; that is worth it with the works and the working conditions. As seen from the appropriateness in Islamic law, the wage practice has fulfilled the worthiness and virtue elements. It just has not fulfilled the element of justice in the form of transparency in the distribution of wage in the balance.
Peran Pengadilan Agama dalam Mendukung Perkembangan Industri Keuangan Syariah di Indonesia
Authors: Al Hasan Fahadil Amin
Published: May 2020

Hukum dan ekonomi memiliki hubungan timbal balik dan saling mempengaruhi. Artinya, suatu kegiatan ekonomi yang tidak didukung oleh perangkat hukum yang baik memungkinkan akan mengakibatkan terjadinya kekacauan. Hal ini disebabkan karena para pelaku ekonomi akan melakukan aktivitasnya dengan tanpa standar norma yang pada akhirnya menyebabkan  kerugian di antara salah satu pihak yang melakukan aktivitas ekonomi. Jika dibiarkan begitu saja, hal tersebut akan menyebabkan iklim ekonomi di masa depan menjadi terganggu. Begitupun halnya dengan ekonomi syariah. Jika proses hukum, dalam hal ini penyelesaian sengketa ekonomi syariah dilaksanakan dengan baik, maka pengembangan ekonomi dan keuangan syariah akan semakin baik. Pengadilan Agama sebagai salah salah satu pelaksana kekuasaan kehakiman di bawah Mahkamah Agung Republik Indonesia memiliki peranan yang penting dalam memajukan industri keuangan syariah di Indonesia. Hal ini didasarkan karena Pengadilan Agama merupakan lembaga negara yang memiliki kewenangan dalam menyelesaikan sengketa ekonomi syariah di Indonesia. Makalah ini mencoba membahas mengenai beberapa aspek penting yang terkait dengan penyelesaian sengketa ekonomi syariah di Pengadilan Agama, serta beberapa usaha yang dilakukan oleh Mahkamah Agung dalam menguatkan peran Pengadilan Agama dalam menyelesaikan sengketa ekonomi syariah. AbstractThe legal relationship with the economy has a reciprocal and mutually influencing relationship. That is, an economic activity that is not supported by a good legal tool will result in chaos, this is because the economic actors will perform its activities without standard norms that caused the loss of one party in conducting economic activities. If left alone, this will cause the economic climate in the future to be disturbed. Likewise with the sharia economy. If the legal process, in this case the sharia economic dispute resolution carried out well, then the development of sharia economic and financial industry will be better. The Religious Courts as one of the judicial authorities under the Supreme Court of the Republic of Indonesia plays an important role in advancing the sharia financial industry in Indonesia. This is because the Religious Courts are state institutions that have the authority to resolve the dispute of sharia economy. This paper tries to discuss some important aspects related to the settlement of sharia economic dispute in the Religious Courts, as well as some efforts made by the Supreme Court in strengthening the role of Religious Courts in solving the dispute of sharia economy.
The Technique of Determining Ijtihad and Its Application In Life: Analysis Of Istihsan, Maslahah Mursalah, ʻUrf, and Syarʻu Man Qablana
Authors: MAULIDIZEN AHMAD , Raihanah Ashilah
Published: May 2020

Islam as a comprehensive religion has regulated the Shari'a for the conduct of all human actions which the Shari'a is universal and its use is not limited by the times. There are four main sources in the determination of law in Islam, namely Alquran, Sunnah, Ijma and Qiyas. Apart from the source of the law, there are several methods used by ulul Usul Fiqh to determine the law on a new problem. The issue in this research is whether the methods of ijtihad such as Istihsan, Maslahah Mursalah, Urf, and Syar'u man qablana can be accepted and allowed by the Ulema Ushul fiqh in determining a law? What is the success in Islamic law? And how is it applied in human life and activity? The method used in this paper is the library study method. The results of the research obtained that Istihsan, Maslahah Mursalah, ‘Urf, and Syar’u man qablana are part of Islamic Shari'a. Despite the differences of opinion among the scholars regarding the ability to use the ijtihad methods. There are those who directly allow, some also give certain conditions in the process of determining the law. Described the arguments that strengthen the opinions of the scholars in issuing their fatwa. There are also examples of the implementation and application of the ijtihad method both at the time of the Prophet's best friend and in the present in accordance with the true Islamic Shari'a
Perda Syariah Perspektif Ketatanegaraan dan Siyasah Dusturiyyah
Authors: Hanum Cholida
Published: May 2020

Salah satu buah dari reformasi adalah terjadinya perubahan mendasar pada sistem ketatanegaraan Indonesia yang semula sentralistik menjadi desentralistik. Tidak dapat dipungkiri bahwa sistem desentralisasi membuka kran bagi munculnya Perda-Perda Syariah. Selain itu Perda-Perda ini muncul terkait dengan historisitas penerapan syrai’at Islam di Indonesia sejak Islam masuk ke bumi Nusantara. Sebagian dari muatan Perda-Perda syariah tersebut bertentangan dengan ketentuan dalam prinsip-prinsip Hak Asasi Manusia baik yang terdapat dalam HAM dalam perspektif Islam maupun HAM yang dimuat dalam konstitusi Indonesia. Prinsip utama dalam ajaran agama Islam adalah kemaslahatan bagi masyarakat yang di dalamnya tertuang dalam Al-Qur’an dan As-Sunnah. Pelaksanaan aturan perundang-undangan termasuk peraturan daerah yang merupakan tataran terendah dalam hierarki peraturan perundang-undangan harus mewujudkan tujuan dasar negara ini yaitu perlindungan terhadap hak-hak warga negara serta dalam konsepsi siyasah dusturiyyah pun demikian diatur bahwa peraturan haruslah menjamin kemaslahatan bagi masyarakat sebagai tujuan utama dalam nomokrasi Islam.Kata Kunci: Perda Syariah, Siyasah Dusturiyyah, Kemaslahatan
Pengaruh Islamic Law System Terhadap Hukum Ekonomi Indonesia
Authors: Janah Tutik Nurul
Published: May 2020

Islamic Law System is generally applied in Islamic countries. An Islamic state is a country that uses Islamic law as the formal law of the state. Indonesia is a country with a dominant legal system using the Civil Law System. However, despite the dominant use of the Civil Law System, the Islamic Law System is also quite influential in Indonesia, especially in Privat law and economic law. The influence of the Islamic Law System in Indonesian economic law can be seen from the passing of the Law on Sharia Banking and other Legislation relating to Islamic economics. The dynamics of the speed of the needs of economic actors for legislation makes economic law the most dynamic field of law among other fields of legal study. Nevertheless, the legal norms must not be in conflict with human rights and humanity in order to achieve social justice for all Indonesian people.
The Denationalization and Agencification of Net Neutrality Policy in Lithuania
Authors: Jastramskis Deimantas
Published: May 2020

This paper focuses on the making of communications policy in Lithuania, specifically regarding net neutrality. The study employs a multiple stream model to analyze the conditions of the political process and the activity of political actors. The paper claims that the Lithuanian communications policy has become essentially denationalized since the country’s accession to the European Union. The issue of net neutrality policy has been framed in the context of EU policy, while the national agenda of net neutrality policy lost its significance. The denationalization of the net neutrality policy-making was harmonized with the agencification of policy formulation stage.
Kulturni kapital mladih
Authors: Trbojević Filip
Published: May 2020

U radu se teorijski i empirijski, metodom online ankete na prigodnom uzorku (N = 632), istražuju dva aspekta glazbene konzumacije studenata Sveučilišta u Zagrebu: njihove glazbene preferencije te u kojoj su mjeri
one posljedica transmisije glazbenog ukusa s njihovih roditelja, oslanjajući se pritom na koncept kulturnog kapitala Pierrea Bourdieua. Rezultati pokazuju da studenti najviši stupanj preferencija pokazuju spram rock ili blues, dok uvjerljivo najmanje preferiraju turbofolk glazbu. Utvrđene su i razlike s obzirom na socioekonomske odrednice, a najvažniji je rezultat taj da su glazbene preferencije studenata neovisne o njihovom materijalnom statusu. Zatim, utvrđena je pozitivna veza između studenata i njihovih roditelja u pogledu slušanja klasične te rock ili blues glazbe, što ukazuje na to da roditeljski glazbeni ukus
usmjerava glazbene preferencije njihove djece k određenim glazbenim stilovima. Rezultati upućuju na pojavu novih (hibridnih) kulturnih formi, na potrebu redefiniranja strogih razgraničenja i kulturnih hijerarhija koje se temelje na ideji „visokeˮ kulture, kao i na uvažavanje toga da se međusobna dinamika ekonomskog i kulturnog kapitala
mijenja.
Efficacy and Safety of Insulin Glargine 300 Units/mL (Gla-300) Versus Insulin Glargine 100 Units/mL (Gla-100) in Children and Adolescents (6–17 years) With Type 1 Diabetes: Results of the EDITION JUNIOR Randomized Controlled Trial
Authors: Danne Thomas , Tamborlane William V. , Malievsky Oleg A. , Franco Denise R. , Kawamura Tomoyuki , Demissie Marek , Niemoeller Elisabeth , Goyeau Harmonie , Wardecki Marek , Battelino Tadej
Published: May 2020

OBJECTIVE

To compare efficacy and safety of insulin glargine 300 units/mL (Gla-300) and 100 units/mL (Gla-100) in children and adolescents (6–17 years old) with type 1 diabetes.

RESEARCH DESIGN AND METHODS

EDITION JUNIOR was a noninferiority, international, open-label, two-arm, parallel-group, phase 3b trial. Participants were randomized 1:1 to Gla-300 or Gla-100, titrated to achieve fasting self-monitored plasma glucose levels of 90–130 mg/dL (5.0–7.2 mmol/L), with continuation of prior prandial insulin. The primary end point was change in HbA1c from baseline to week 26. Other assessments included change in fasting plasma glucose (FPG), hypoglycemia, hyperglycemia with ketosis, and adverse events.

RESULTS

In 463 randomized participants (Gla-300, n = 233; Gla-100, n = 230), comparable least squares (LS) mean (SE) reductions in HbA1c were observed from baseline to week 26 (−0.40% [0.06%] for both groups), with LS mean between-group difference of 0.004% (95% CI −0.17 to 0.18), confirming noninferiority at the prespecified 0.3% (3.3 mmol/mol) margin. Mean FPG change from baseline to week 26 was also similar between groups. During the 6-month treatment period, incidence and event rates of severe or documented (≤70 mg/dL [≤3.9 mmol/L]) hypoglycemia were similar between groups. Incidence of severe hypoglycemia was 6.0% with Gla-300 and 8.8% with Gla-100 (relative risk 0.68 [95% CI 0.35–1.30]). Incidence of any hyperglycemia with ketosis was 6.4% with Gla-300 and 11.8% with Gla-100.

CONCLUSIONS

Gla-300 provided similar glycemic control and safety profiles to Gla-100 in children and adolescents with type 1 diabetes, indicating that Gla-300 is a suitable therapeutic option in this population.
Upaya Mereduksi Jumlah Kecelakaan Lalu Lintas Melalui Penggunaan Sistem Informasi Geografis
Authors: Fadli Ari , Sugiyanto Gito , Zulfa Mulki Indana
Published: May 2020

Kegiatan ini dilatarbelakangi oleh tingginya angka kecelakaan lalu lintas di Kabupaten Purbalingga. Berdasarkan data dari Satlantas Porles Purbalingga disebutkan bahwa kecelakaan lalu lintas selama periode empat tahun yaitu tahun 2010-2013 terjadi 1374 kejadian kecelakaan dengan jumlah kejadian tertinggi terjadi pada tahun 2012 sebanyak 513 kasus (37,34%), diikuti tahun 2013 sebanyak 467 kasus. Tujuan dari pengabdian adalah untuk mengurangi jumlah angka kecelakaan lalu lintas dengan cara membuat peta lokasi rawan kecelakaan lalu lintas menggunakan Sistem Informasi Geografis (SIG) berbasis web. Metode yang digunakan adalah praktik, demonstrasi dan sosialisasi. Tahap awal kegiatan pengabdian ini dimulai dengan membuat peta dearah rawan kecelakaan lalu lintas dengan menggunakan SIG berbasis Web. Dalam membuat peta dasar digunakan perhitungan berdasarkan Angka Ekuivalen Kecelakaan (AEK) yaitu korban meninggal dunia bernilai 10, korban luka berat bernilai 5, korban luka ringan bernilai 1, dan nilai 1 untuk property damaged only. Kegiatan selanjutnya adalah mendemonstrasikan dan mensosialiasikan hasil pemetaan dalam bentuk SIG berbasis web kepada peserta yaitu pihak kepolisian pada unit laka lantas. Hasil akhir kegiatan adalah SIG berbasis web untuk menyajikan informasi lokasi daerah rawan kecelakaan sehingga dapat digunakan untuk memberikan peringatan dini kecelakaan kepada masyarakat.
Factors Influencing Students’ Behavior Toward Trash Classification
Authors: Pham Hau Van , Tang Loc Son , Nguyen Hanh Thi Hai , Hoang Hue Thi
Published: May 2020

Trash classification plays an important role in enhancing people’s awareness of protecting environment. This study aimed to evaluate factors influencing students’ behavior toward trash classification in Vietnam. Six dimensions used in this study were: Knowledge, Attitude, Perceived Effective Behavior, Subjective Standards, Habits and Infrastructure. The research conducted a survey with participation of 274 respondents. The data was analyzed by using descriptive statistics, factor analysis and regression.
Income Multipliers In Input – Output Analysis: Case Of Vietnam
Authors: Trinh Bui , Hung Duong Mạnh , Thai Nguyen Quang
Published: May 2020

The question arises as to which income group will benefit from GDP growth? This paper assesses the success or failure of Vietnam's economic policy through an input - output analysis, the research is estimaté the spread of final demand to type of income. It proposes some ideas for adjusting macroeconomic policies. In this article, value added is divided into income groups such as: Income of labor groups (labors in the state enterprises; labors in the non-state enterprises and in the FDI sector); operating surplus of state-owned enterprises; operating surplus of non-state sector and operating surplus of FDI sector.
Diaspora Remittances and Financial Inclusion in Kenya
Authors: Arthur Emmanuel Kwesi , Musau Salome Mwongeli , Wanjohi Festus Mithi
Published: May 2020

This study examined the effect of  diaspora remittances on financial inclusion in Kenya for a quarterly period from 2008 to 2018. The Kenyan government’s commitment to include the Kenyan diaspora into the national development process led to the launching of Kenyan Diaspora Policy in 2015 as part of the Kenya’s vision 2030 blue print of which financial inclusion is a pillar. This study sought to check if the policy interventions achieved its objective by testing the moderating effect of Diaspora Policy on the relationship between diaspora remittances and financial inclusion. The descriptive research design specifically longitudinal and explanatory non-experimental designs were employed in this study. The target population for this study comprised the three million Kenyans living at the diaspora. The census and stratified sampling design were utilised where census method was first used to include the formal diaspora remittance inflows for the forty four quarterly period and then stratified into corridors for the period under study. Data from the Central Bank of Kenya and Kenya National Bureau of Statistics were analysed using time series multiple regression model. The results of the study showed that formal diaspora remittances received had a positive and statistically significant effect on financial inclusion. Formal diaspora remittances from Rest of the World greatly influenced financial inclusion. Remittance inflows from North America also influenced financial inclusion to some extent while formal diaspora remittances from Europe had no effect on financial inclusion in Kenya. Further, the study established that the moderating effect between formal diaspora remittances and financial inclusion was positive and statistically significant implying that the diaspora policy implemented by government greatly influenced diaspora remittances and financial inclusion in the right direction in Kenya. The study recommended among others, that government of Kenya continues to strategically strengthen the diaspora policies in order to increase the flow of diaspora remittances into the country to boost financial inclusion.
Environmental Impact Assessment of Ala-River Akure, Ondo State Nigeria
Authors: Ijaware Victor Ayodele
Published: May 2020

With an increase in urbanization, there is need for a constant assessment and monitoring of environmental features. Environmental Impact Assessment (EIA) has been used in this research was to assess the impacts of Ala River in Akure on the environment using Geographical Information System (GIS) techniques. The data collection involved the use of Questionnaires and the design were based on four criteria: socio-cultural, climatic, economic, Health and Safety Impact factors. Using ArcMap, Buffer Analysis was performed around the River to get those features most susceptible to the impact of Ala River and also to guide the expanse where opinion survey was carried out at different locations around the river. Analysis of Variance (ANOVA) was used to analyse the data acquired and the Hypothesis tested were used to generate outcome set for each of the criteria’s. From the results of the study, it was discovered that the River has impacts on the Social-Cultural state of the environments (P<0.05), Climate of the environment (P<0.05) and Health and Safety state of the environment including the people around it(P<0.05) but the River does not have major impacts on the Economic factors (P>0.05).The research recommends that additional effort need to be put in place on all fronts if the results acquired from environmental assessment is to be put to good use.
Assessment of Spatial Prediction Techniques Accuracy for Elevation Determination in Akure South Local Government, Ondo State
Authors: Ijaware Victor Ayodele , Adeboye Adebayo T.
Published: May 2020

The Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) is a cooperative effort between NASA and Japan's Ministry of Economy Trade and Industry (METI), with the collaboration of scientific and industry organizations in both countries. The ASTER instrument provides a more robust remote sensing imaging capability when compared to the older Landsat Thematic Mapper. This paper deals with the accuracy assessment of elevation data obtained using ASTER from each of the eleven (11) selected extrapolation/interpolation algorithms: Inverse Distance Weighting, Natural Neighbor, Spline Regular, Spline Tension, Universal Kriging, Empirical Bayesian Kriging, Topo to Raster, global (trend surface), local polynomial, kernel interpolation with barriers and radial basis functions in Digital Elevation Model (DEM) surface creation. The data were compared with reference to ground control points of differential GPS measurements in the study area. The error statistics were generated between DGPS measurements and Extracted elevation data from each selected interpolation method. It was observed that Spline Regular Interpolation shown the best overall accuracy of ±11.520m when elevation data extracted from Inverse distance weighting, Natural Neighbour, Spline T, Topo to Raster, Universal Kriging, Empirical Bayesian kriging, Global polynomial interpolation (GPI), local polynomial interpolation (LPI), Radial basis function and Kernel interpolation of ±15.170, ±14.340, ±12.336, ±13.551, ±14.707, ±13.711, ±15.363, ±13.964, ±13.590 and ±15.376 respectively when compared with elevation values from GPS method. The study recommends capacity building in the form of workshop, training, and flexible integration of point elevation data to DEM.
Introduction into the Extra Geometry of the Three–Dimensional Space I
Authors: Szalay Istvan , Szalay B.
Published: May 2020

Using the theory of exploded numbers by the axiom–systems of real numbers and euclidean geometry, we introduce a geometry in the three–dimensional space which is different from the euclidean-, Bolyai – Lobachevsky- and spherical geometries. In this part the concept of extra-line and extra parallelism are detailed.
The The Fine Structure Constant and Radiative Corrections for the Electron and Positron Cores as Viewed in the Planck Vacuum Theory
Authors: Daywitt William C.
Published: May 2020

The present paper derives the radiative corrections for the electron and positron cores in the Planck vacuum theory, leading to the electron and position particles in a 7-dimension spacetime. The physical meaning of the fine structure constant is twofold: it is the ratio of the electron spin coefficient to the electron-core spin coefficient; and it is the probability that an electron or positron will emit or absorb a photon. The nature of this photon defines the spin quanta in the PV theory. Results suggest that the Feynman and Schwinger QED calculations refer to the PV state. Finally, the closed-loop electron-positron pairs in the Feynman diagrams are explained.
Bionic substantiation of modern technologies
Authors: Vorobiov Alexander Egorovich , Vorobyev Kirill Aleksandrovich
Published: May 2020

The fundamental essence of nature-like technologies in transport, ecology, architecture, energy and subsoil use is disclosed.The evolution of mankind is shown to be leading to a crisis between the biosphere and the technosphere. The terms “bionicist”, “biomimetik” have been given interpretation. The main stages of the development of nature-like technologies have been presented. There have been given examples of various bionic devices and technologies. Devices in the form of the artificial plants and artificial leaves allowing to receive electric energy and to synthesize necessary chemical compounds have been described in detail. There have been considered the main processes happening in live organisms, on the basis of which the general principles of technogenic renewal of mineral resources were developed: increase of technogeneous ores output and making mineral waste easily decomposing.
Numerical investigation of influence of control parameters on operating speed of developed electronically controlled injector
Authors: Jafarli Mirali Kamran ogly
Published: May 2020

The paper presents the the new internal combustion engine working process and a new design of an electronically controlled engine injector in accordance with the requirements for environmental, technical and economical characteristics of automobile engines. One of the main requirements for the electronically-controlled injectors is a high operating speed. There has been considered a possibility to improve the operating speed of the injector. There has been studied the influence of pressure at the outlet of the high-pressure fuel pump on the operating speed of the developed electronically-controlled injector at different values of the electrical control impulse fed on the piezoelectric actuator. The investigation was carried out by the method of numerical experiment using a mathematical model. The results of numerical investigations are presented and analyzed; in the result, the optimal value of the pressure at the outlet of the high-pressure fuel pump is determined in terms of the operating speed of the developed injec
The Attitudes of Jordanian Universities Students towards Digital Advertising and its Impact on Their Purchasing Behaviour
Authors: Al-Bdour Mohammad Ahmad , El-Sarayrah Mohamed Najib
Published: May 2020

This study aimed to identify the attitudes of Jordanian Universities students towards digital advertising and its impact on their purchasing behavior. This study belongs to the analytical descriptive studies. The survey method and questionnaire were used in this study. The questionnaire was distributed to a sample of 308 students from University of Jordan, and Petra University. The appropriate statistical means were used to answer the study questions. The results revealed that the rates of Jordanian Universities student’s internet usage are high, and that students in the public universities are less likely to use the Internet than students in the private universities. The study indicated that scientific and recreational information are the most information that the students seek to obtain, while the economic information was the least. The products sought by the students of through the digital advertising are music and clothing, while the products of household items were the lowest among students.
Restrictive Conditions for Free Uses of Copyrighted Materials under Omani Law and Their Implications for Users’ of Copyrighted Materials
Authors: Albarashdi Saleh Hamed , Billah Muhammed Masum
Published: May 2020

Omani Copyright and Neighboring Rights Law of 2008 contains a list of exceptions to the exclusive rights of copyright holders. These exceptions allow people to copy and use copyrighted materials in certain cases without paying any fees or obtaining any permission from the copyright holders. The exceptions cover free uses for purposes like teaching, education, quotation in another work, dissemination of news etc. However, the Omani Copyright and Neighboring Rights Law puts many conditions for such free uses. Some of these conditions mirror similar conditions under the Berne Convention and other copyright conventions to which Oman is a party. Other conditions under Omani law are more restrictive than those that appear under international conventions. These additional conditions restrict the scope of free uses of copyrighted materials in Oman. Yet, some countries like USA and Canada, despite their being parties to the same international conventions, have much wider exceptions under their national legislation. The paper, therefore, recommends that Oman should follow the legislative approach of those countries in order to widen the scope of copyright exceptions for the benefits of users of copyrighted materials in Oman.
Attepe - Elmadağ-Menteş–Karaçat Demir Sahalarında Yüzey Suyu-Yeraltı Suyu İlişkisinin Araştırılması
Authors: Demiroğlu Muhterem , Örgün Yüksel
Published: May 2020

Çalışmada, Seyhan nehri ana havzasında yer alan Menteş havzası ve yakın çevresinde bulunan, Attepe-
Elmadağ-Menteş–Karaçat demir sahalarında yüzey ve yeraltı suları arasındaki ilişki incelenmiştir. İnceleme alanında
Prekambiryen-Ordovisiyen yaş aralığında düşük dereceli metamorfizma geçirmiş metakarbonat ve metakırıntılılar
ve bunları açılı uyumsuzlukla örten Miyosen konglomeralar ve güncel alüvyonlar yüzeylenmektedir. Havzanın da
içinde yer aldığı bölgede, tektonik hareketlerin etkisiyle aşırı kırık, çatlaklı ve yer yer ileri düzeyde karstik yapı
kazanmış olan metakarbonatlar ana akifer olarak belirlenmiştir. Menteş deresi karstik akiferin doğal yeraltısuyu
boşalım güzergahını ve aynı zamanda aktif güncel karstlaşmanın erozyon seviyesini oluşturmaktadır.
Faylar, havzadaki geçirimsiz olan diğer birimlerin yanal ve düşey konumlarını belirleyerek karstik akiferin
sürekliliğini engellemiştir. Alansal olarak yağışlarla, yanı sıra Menteş deresinden büyük miktarda noktasal olarak
beslenen yeraltı sularının, sığ dolaşımlı ve akiferle temas süresi kısa, 5-10 yıllık genç sular olduğu ortaya konmuştur.
Menteş deresi ortalama debisi doğu alt havzası çıkışında 474 L/sn olarak hesaplanmıştır. Debi ölçümleri Menteş
deresinden, kurak ve yağışlı devrelerde sırasıyla yaklaşık 150 ve 1000 L/sn suyun, yeraltı suyuna ilave olduğunu
göstermiştir. Yeraltı maden ocağının da yer aldığı Karaçat akiferinin yan havzalardan ziyade Menteş deresinden
beslendiği belirlenmiştir. Hidrojeolojik değerlendirmeler ve izotop analiz sonuçları önceki çalışmalarda da belirlenen
Attepe gölü ile Karaçat akiferi arasında hidrolik bir ilişkinin olmadığı değerlendirmesi teyit edilmiştir.
Passions Read & Hearts Fed
Authors: Highby Wendy , Shull Katherine , Trask Emory Jay
Published: May 2020

A review of Connie Willis' recently-published story, “I Met a Traveler in an Antique Land,” (Asimov’s, December 2017).  The setting for Willis’ cautionary tale is a chimeric Manhattan bookstore, Ozymandia’s. The labyrinthine business is a last refuge for endangered books.  The protagonist, an ambitious, forward-thinking blogger, rethinks his penchant for all things innovative when he visits the store and becomes conscious of the havoc wreaked upon books by the circumstances of the Anthropocene (wars, weather, bookworms, bookburning, thoughtless culling, etc.).  He comes to understand the urgent need for, and complexity of the systematic preservation of information. 

Pre-print first published online 11/08/2019
The Quotidian Apocalypse and the Quixotic Cause
Authors: Highby Wendy , Shull Katherine , Trask Jay
Published: May 2020

The writer Connie Willis lives in Greeley, Colorado, home to the University of Northern Colorado (UNC). She is an alumna of UNC and has chosen to deposit her papers in its archives. A pre-eminent science fiction author, her clock- and calendar-defying tales of time travel have transported many fans and won numerous awards. Her stellar reputation in fandom and among librarians as a mentor, peer, and public intellectual is well-deserved and hard-earned. She gives generously of her time at conventions, conferences, and community events. We finally caught up with her in the latter days of Summer 2018, after the Locus Awards and the Westercon science fiction and fantasy convention, and interviewed her about her recent novella “I Met a Traveler in an Antique Land” (first appearing in Asimov’s Science Fiction in 2017 and later published by Subterranean Press in 2018). It concerns a disappearing Manhattan bookshop that may also be a harbor for endangered books. The story’s subject matter is of great relevance for archivists and librarians of the Anthropocene—as is the content of our conversation with Ms. Willis, which ranges from the insidious nature of censorship to the nobility of fighting for lost causes.

Pre-print first published online 11/08/2019