bluuebunny/crossref_metadata_2025 huggingface dataset:
PECAM1 plays a role in the pathogenesis and treatment of bone metastases
Authors: Liang Zhuo-Tao , Li Jia-Ke , Li Jiong , Tang Hao , Guo Chao-Feng , Zhang Hong-Qi
Published: March 2023

Bone is the third most common metastatic site for all primary tumors, the common primary focus of bone metastases include breast cancer, prostate cancer, and so on. And the median survival time of patients with bone metastases is only 2–3 years. Therefore, it is urgent to develop new targets to diagnose and treat bone metastases. Based on two data sets GSE146661 and GSE77930 associated with bone metastases, it was found that 209 genes differentially expressed in bone metastases group and control group. PECAM1 was selected as hub-gene for the follow-up research after constructing protein-protein interaction (PPI) network and enrichment analysis. Moreover, q-PCR analysis verified that the expression of PECAM1 decreased in bone metastatic tumor tissues. PECAM1 was believed to be possibly related to the function of osteoclasts, we knocked down the expression of PECAM1 with shRNA in lymphocytes extracted from bone marrow nailed blood. The results indicated that sh-PECAM1 treatment could promote osteoclast differentiation, and the sh-PECAM1-treated osteoclast culture medium could significantly promote the proliferation and migration of tumor cells. These results suggested that PECAM1 may be a potential biomarker for the diagnosis and treatment of bone metastases of tumor.
Austral summer circulation in the Bransfield Strait based on SADCP measurements and satellite altimetry
Authors: Frey Dmitry , Krechik Viktor , Gordey Alexandra , Gladyshev Sergey , Churin Dmitry , Drozd Ilya , Osadchiev Alexander , Kashin Sergey , Morozov Eugene , Smirnova Daria
Published: March 2023

Three-dimensional structure of currents in the Bransfield Strait (BS) was measured in 2017 over 50 transects across the strait using a Shipborne Acoustic Current Doppler Profiler (SADCP) onboard the R/V Akademik Sergey Vavilov and Akademik Ioffe. These data were used to determine local features of the three-dimensional velocity field of the currents. The sections crossed all three basins of the BS and the main flows in the strait including the Bransfield Current and the southwestward flow of Weddell Sea waters along the Antarctic Peninsula. Two vessels are equipped with different SADCP systems with frequencies of 76.8 kHz and 38.4 kHz, which allows us to compare the data from different SADCPs. The observations reveal that very dense waters from the Weddell Sea propagate in deep layers over the shelf break; this flow is usually not observed at the sea surface. Vertical structure of the Bransfield Current significantly differs from the flow of the Weddell Sea waters and its velocity maximum is located in the upper ocean layer. We also used two gridded altimetry products of 0.25° and 0.1° resolution for investigations of circulation in the BS. We analyzed the efficiency of satellite altimetry in reproducing currents in conditions of a narrow strait and evaluated its accuracy using field velocity observations. We found that satellite altimetry can be used for identification of the mean ocean circulation patterns within the BS. However, daily altimetry data contain significant discrepancies with the in situ data and require direct measurements for studies of the BS circulation.
Regulation of marine plankton respiration: A test of models
Authors: Wikner Johan , Vikström Kevin , Verma Ashish
Published: March 2023

Plankton respiration is a major process removing oxygen from pelagic environments and constitutes one of the largest oxygen transformations in the sea. Where the O2 supplies due to dissolution, advection and oxygenic photosynthesis are not sufficient, hypoxic, or anoxic waters may result. Coastal waters with limited water exchange are especially prone to have low oxygen levels due to eutrophication and climate change. To support marine environmental management in a period of rapid climate change, we investigated the current knowledge of regulating plankton respiration based on field and experimental studies reported in the literature. Models for regulation of plankton respiration was tested on a three-year field data set. Temperature is the most reported predictor positively influencing plankton respiration (mean r2 = 0.50, n=15). The organic carbon supply driven by primary production has a similar coefficient of determination but fewer reported relationships (mean r2 = 0.52, n=6). Riverine discharges of dissolved organic carbon can override the influence of primary production in estuaries precluding effects of nutrient reductions. The median predictions of respiration regulation produced by current models vary by a factor of 2 from the median of observed values and extreme values varied even more. Predictions by models are therefore still too uncertain for application at regional and local scales. Models with temperature as predictor showed best performance but deviated from measured values in some seasons. The combined dependence of plankton respiration on temperature, phytoplankton production and discharge of riverine organic carbon will probably lead to increased oxygen consumption and reduced oxygen levels with projected climate change. This will be especially pronounced where increased precipitation is expected to enhance riverine discharges of carbon compounds. The biologically mediated transfer of carbon for long-term storage in deeper layers will slow down. Implementation of plankton respiration measurements in long-term ecological monitoring programs at water body and basin scales is advocated, which would enable future multivariate analyses and improvements in model precision across aquatic environments.
Serum triglyceride levels are associated with recurrence in patients with acute hypertriglyceridemic pancreatitis
Authors: Guan Langyi , Ding Ling , Wan Jianhua , Xia Liang , He Wenhua , Xiong Huifang , Luo Lingyu , Lu Nonghua , Zhu Yin
Published: March 2023

Aim

To analyze the clinical profile of patients with acute hypertriglyceridemic pancreatitis (HTGP) and explore risk factors for recurrence.

Methods

A retrospective observational study was conducted in patients who experienced an attack of HTGP for the first time. Patients were followed until the recurrence of acute pancreatitis (AP) or 1 year. The detailed clinical profile was compared between patients with or without recurrence. Multivariate logistic regression analysis was conducted to explore independent risk factors for recurrence.

Results

A total of 108 HTGP patients were included in this study with 73.1% being male, and the median age being 37 (interquartile range, IQR, 30.3–44.8) years. Recurrence occurred in 70 patients (64.8%). Compared with the nonrecurrent group, serum triglyceride (TG) levels before discharge [4.1 (2.8,6.3) mmol/L vs. 2.9 (2.2,4.2) mmol/L; p = 0.002], at 1 month [3.7 (2.3,9.7) mmol/L vs. 2.0 (1.4,2.7) mmol/L; p = 0.001], at 6 months [6.1 (3.1,13.1) mmol/L vs. 2.5 (1.1,3.5) mmol/L; p = 0.003] and 12 months [9.6 (3.5,20.0) mmol/L vs. 2.7 (1.6,5.5) mmol/L; p = 0.001] after discharge were higher in the recurrent group. Poor control of TG levels (TG > 3.1 mmol/l) at the 1-month follow-up after discharge and a high Charlson’s Comorbidity Index score (≥ 2 points) increased the risk of recurrence of HTGP.

Conclusion

High TG levels during follow-up and Charlson’s Comorbidity Index score were independently associated with recurrence in patients with HTGP.
Pyruvate kinase M2 modification by a lipid peroxidation byproduct acrolein contributes to kidney fibrosis
Authors: Kuo Chin-Wei , Chen Dong-Hao , Tsai Ming-Tsun , Lin Chih-Ching , Cheng Hsiao-Wei , Tsay Yeou-Guang , Wang Hsiang-Tsui
Published: March 2023

Renal fibrosis is a hallmark of diabetic nephropathy (DN) and is characterized by an epithelial-to-mesenchymal transition (EMT) program and aberrant glycolysis. The underlying mechanisms of renal fibrosis are still poorly understood, and existing treatments are only marginally effective. Therefore, it is crucial to comprehend the pathophysiological mechanisms behind the development of renal fibrosis and to generate novel therapeutic approaches. Acrolein, an α-,β-unsaturated aldehyde, is endogenously produced during lipid peroxidation. Acrolein shows high reactivity with proteins to form acrolein-protein conjugates (Acr-PCs), resulting in alterations in protein function. In previous research, we found elevated levels of Acr-PCs along with kidney injuries in high-fat diet-streptozotocin (HFD-STZ)-induced DN mice. This study used a proteomic approach with an anti-Acr-PC antibody followed by liquid chromatography–tandem mass spectrometry (LC–MS/MS) analysis to identify several acrolein-modified protein targets. Among these protein targets, pyruvate kinase M2 (PKM2) was found to be modified by acrolein at Cys358, leading to the inactivation of PKM2 contributing to the pathogenesis of renal fibrosis through HIF1α accumulation, aberrant glycolysis, and upregulation of EMT in HFD-STZ-induced DN mice. Finally, PKM2 activity and renal fibrosis in DN mice can be reduced by acrolein scavengers such as hydralazine and carnosine. These results imply that acrolein-modified PKM2 contributes to renal fibrosis in the pathogenesis of DN.
The mobile gene cassette carrying tetracycline resistance genes in Aeromonas veronii strain Ah5S-24 isolated from catfish pond sediments shows similarity with a cassette found in other environmental and foodborne bacteria
Authors: Dubey Saurabh , Ager-Wiick Eirill , Peng Bo , DePaola Angelo , Sørum Henning , Munang’andu Hetron Mweemba
Published: March 2023

Aeromonas veronii is a Gram-negative bacterium ubiquitously found in aquatic environments. It is a foodborne pathogen that causes diarrhea in humans and hemorrhagic septicemia in fish. In the present study, we used whole-genome sequencing (WGS) to evaluate the presence of antimicrobial resistance (AMR) and virulence genes found in A. veronii Ah5S-24 isolated from catfish pond sediments in South-East, United States. We found cphA4, dfrA3, mcr-7.1, valF, blaFOX-7, and blaOXA-12 resistance genes encoded in the chromosome of A. veronii Ah5S-24. We also found the tetracycline tet(E) and tetR genes placed next to the IS5/IS1182 transposase, integrase, and hypothetical proteins that formed as a genetic structure or transposon designated as IS5/IS1182/hp/tet(E)/tetR/hp. BLAST analysis showed that a similar mobile gene cassette (MGC) existed in chromosomes of other bacteria species such as Vibrio parahaemolyticus isolated from retail fish at markets, Aeromonas caviae from human stool and Aeromonas media from a sewage bioreactor. In addition, the IS5/IS1182/hp/tet(E)/tetR/hp cassette was also found in the plasmid of Vibrio alginolyticus isolated from shrimp. As for virulence genes, we found the tap type IV pili (tapA and tapY), polar flagellae (flgA and flgN), lateral flagellae (ifgA and IfgL), and fimbriae (pefC and pefD) genes responsible for motility and adherence. We also found the hemolysin genes (hylII, hylA, and TSH), aerA toxin, biofilm formation, and quorum sensing (LuxS, mshA, and mshQ) genes. However, there were no MGCs encoding virulence genes found in A. veronii AhS5-24. Thus, our findings show that MGCs could play a vital role in the spread of AMR genes between chromosomes and plasmids among bacteria in aquatic environments. Overall, our findings are suggesting that MGCs encoding AMR genes could play a vital role in the spread of resistance acquired from high usage of antimicrobials in aquaculture to animals and humans.
Native Wolbachia infection and larval competition stress shape fitness and West Nile virus infection in Culex quinquefasciatus mosquitoes
Authors: Alomar Abdullah A. , Pérez-Ramos Daniel W. , Kim Dongmin , Kendziorski Natalie L. , Eastmond Bradley H. , Alto Barry W. , Caragata Eric P.
Published: March 2023

Introduction

Wolbachia transinfections established in key mosquito vectors, including Aedes aegypti are typically associated with pathogen blocking—reduced susceptibility to infection with key pathogens and reduced likelihood those pathogens are transmitted to new hosts. Host-symbiont-virus interactions are less well understood in mosquitoes like Culex quinquefasciatus, which naturally harbor Wolbachia, with pathogen blocking observed in some populations but not others, potentially due to innate differences in their Wolbachia load. In nature, mosquito larvae are often subject to developmental stresses associated with larval competition, which can lead to reduced body size and differential susceptibility to arbovirus infection.

Methods

In this study, we sought to understand whether competition stress and Wolbachia infection in Cx. quinquefasciatus combine to impact host fitness and susceptibility to infection with West Nile virus. We reared Wolbachia-infected and uninfected Cx. quinquefasciatus larvae under three competition stress levels, increasing larval density without increasing the amount of food supplied. We then monitored larval development and survival, measured wing length and quantified Wolbachia density in adults, and then challenged mosquitoes from each treatment group orally with West Nile virus.

Results and Discussion

We observed that high competition stress extended development time, decreased the likelihood of eclosion, decreased body size, and increased susceptibility to West Nile virus (WNV) infection. We also observed that Wolbachia infection reduced WNV load under low competition stress, and significantly improved the rate of survival for larval reared under higher competition stress. Consequently, our data suggest that native Wolbachia infection in Cx. quinquefasciatus has differential consequences for host fitness and susceptibility to WNV infection depending on competition stress.
Effectiveness and safety of monoclonal antibodies against amyloid-beta vis-à-vis placebo in mild or moderate Alzheimer's disease
Authors: Hao Ying , Dong Mingrui , Sun Yingtong , Duan Xiaohui , Niu Wenquan
Published: March 2023

Backgrounds and objectives

Currently, no consensus has been reached on the therapeutic implications of monoclonal antibodies against amyloid-beta (Aβ) in Alzheimer's disease (AD). This study aimed to examine the effectiveness and safety of monoclonal antibodies against Aβ as a whole and also to determine the superiority of individual antibodies vis-à-vis placebo in mild or moderate AD.

Methods

Literature retrieval, article selection, and data abstraction were performed independently and in duplicate. Cognition and function were appraised by the Mini-Mental State Examination (MMSE), Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog), Disability Assessment for Dementia (DAD), and Clinical Dementia Rating Scale-Sum of Boxes (CDR-SB). Effect sizes are expressed as standardized mean difference (SMD) with a 95% confidence interval (CI).

Results

Twenty-nine articles involving 108 drug-specific trials and 21,383 participants were eligible for synthesis. Of the four assessment scales, only CDR-SB was significantly reduced after using monoclonal antibodies against Aβ relative to placebo (SMD: −0.12; 95% CI: −0.2 to −0.03; p = 0.008). Egger's tests indicated a low likelihood of publication bias. At individual levels, bapineuzumab was associated with a significant increase in MMSE (SMD: 0.588; 95% CI: 0.226–0.95) and DAD (SMD: 0.919; 95% CI: 0.105–1.943), and a significant decrease in CDR-SB (SMD: −0.15; 95% CI: −0.282–0.018). Bapineuzumab can increase the significant risk of serious adverse events (OR: 1.281; 95% CI: 1.075–1.525).

Conclusion

Our findings indicate that monoclonal antibodies against Aβ can effectively improve instrumental activities of daily life in mild or moderate AD. In particular, bapineuzumab can improve cognition and function, as well as activities of daily life, and meanwhile, it triggers serious adverse events.
Minimizing the distortions in electrophysiological source imaging of cortical oscillatory activity via Spectral Structured Sparse Bayesian Learning
Authors: Paz-Linares Deirel , Gonzalez-Moreira Eduardo , Areces-Gonzalez Ariosky , Wang Ying , Li Min , Vega-Hernandez Mayrim , Wang Qing , Bosch-Bayard Jorge , Bringas-Vega Maria L. , Martinez-Montes Eduardo , Valdes-Sosa Mitchel J. , Valdes-Sosa Pedro A.
Published: March 2023

Oscillatory processes at all spatial scales and on all frequencies underpin brain function. Electrophysiological Source Imaging (ESI) is the data-driven brain imaging modality that provides the inverse solutions to the source processes of the EEG, MEG, or ECoG data. This study aimed to carry out an ESI of the source cross-spectrum while controlling common distortions of the estimates. As with all ESI-related problems under realistic settings, the main obstacle we faced is a severely ill-conditioned and high-dimensional inverse problem. Therefore, we opted for Bayesian inverse solutions that positeda prioriprobabilities on the source process. Indeed, rigorously specifying both the likelihoods anda prioriprobabilities of the problem leads to the proper Bayesian inverse problem of cross-spectral matrices. These inverse solutions are our formal definition for cross-spectral ESI (cESI), which requiresa prioriof the source cross-spectrum to counter the severe ill-condition and high-dimensionality of matrices. However, inverse solutions for this problem were NP-hard to tackle or approximated within iterations with bad-conditioned matrices in the standard ESI setup. We introduce cESI with ajoint a prioriprobability upon the source cross-spectrum to avoid these problems. cESI inverse solutions are low-dimensional ones for the set of random vector instances and not random matrices. We achieved cESI inverse solutions through the variational approximationsviaour Spectral Structured Sparse Bayesian Learning (ssSBL) algorithmhttps://github.com/CCC-members/Spectral-Structured-Sparse-Bayesian-Learning. We compared low-density EEG (10–20 system) ssSBL inverse solutions with reference cESIs for two experiments: (a) high-density MEG that were used to simulate EEG and (b) high-density macaque ECoG that were recorded simultaneously with EEG. The ssSBL resulted in two orders of magnitude with less distortion than the state-of-the-art ESI methods. Our cESI toolbox, including the ssSBL method, is available athttps://github.com/CCC-members/BC-VARETA_Toolbox.
Case report: Invasive fungal infection in a patient with a rare CVID-causing gene (TNFRSF13B) mutation undergoing AML treatment
Authors: Tabak Carine , Hyter Stephen , Yacoub Abdulraheem , Byrd Kenneth , McGuirk Joseph , Godwin Andrew K. , Abdelhakim Haitham
Published: March 2023

Acute myeloid leukemia (AML) is a complex diagnosis that puts patients at a higher risk for developing infections, particularly invasive fungal infections (IFI). Mutations in TNFRSF13B have been shown to cause dysfunction in B-cell homeostasis and differentiation, making it a risk factor for developing immunodeficiency syndromes. In this case, a male patient in his 40s presented to our emergency department (ED) with symptoms leading to a diagnosis of AML with concurrent mucormycosis of the lungs and sinuses. Targeted next generation sequencing (NGS) of the patient’s bone marrow showed, among other variants, a loss of function mutation in the TNFRSF13B gene. While most patients present with fungal infections after prolonged periods of neutropenia associated with AML treatment, this case presented with IFI at diagnosis without neutropenia suggesting an immunodeficiency syndrome. The concurrent IFI and AML diagnoses create a delicate balance between treatment of the infection and the malignancy. This case highlights the risk of infection in patients receiving chemotherapy, especially those with unrecognized immunodeficiency syndromes, and emphasizes the importance of NGS for prognosis and treatment.
International centre for the advancement of multidisciplinary studies on socio-economic systems
Authors: Banerjee Suchismita , Mitra Manipushpak
Published: March 2023

We start by summarising very briefly the various prior attempts (during the last one and half a decade), some of which were made as independent research centres and others as visiting centres with extensive visiting programs for luminaries from various basic sciences (Mathematics, Physics, Biology, Economics, and Sociology) and students from various institutions around the world for such interdisciplinary fusion of ideas and researches. Additionally, we briefly discuss the efforts that our institute has made (without any visible success so far, as in the other attempts elsewhere). We then emphasise the critical need for such an international centre to attract stalwarts in the basic disciplinary fields as well as interested students from around the world in order to comprehend the world’s global socio-economic dynamics.
Evolution of the internal load and physical condition of wheelchair basketball players during the competitive season
Authors: Romarate Ander , Yanci Javier , Iturricastillo Aitor
Published: March 2023

The objectives of this study were to describe differentiated perceived training and match load (dRPE-L) of wheelchair basketball (WB) players during the whole season, to analyze the evolution of players’ physical condition changes during a full season and to analyze the association between dRPE-L and changes in physical condition during a full season. Nineteen Spanish Second Division WB players participated in this study. For a full season (10 months, 26 weeks), dRPE-L was assessed with the session-RPE method, separating respiratory (RPEres-L) and muscular (RPEmus-L) perceived load. The physical condition of the players was also assessed at four different times during the season (T1, T2, T3 and T4). The results showed a significantly higher total and average accumulated muscular RPE load (RPEmusTOT-L and RPEmusAVG-L) than total and average respiratory load (RPEresTOT-L and RPEresAVG-L) (p < 0.01; ES = 0.52–0.55). No significant changes were observed in the physical condition of the players at the different moments of the season. Moreover, a significant association was observed only between RPEresTOT-L and Repeated Sprint Ability standard deviation of 3 m (RSAsdec3m) (r = 0.90, p < 0.05). The results suggest that the competitive season represented considerable neuromuscular involvement in these players.
Retrospective analysis of quantitative electroencephalography changes in a dissimulating patient after dying by suicide: A single case report
Authors: Rakús Tomáš , Hubčíková Katarína , Bruncvik Lucia , Petrášová Zuzana , Brunovsky Martin
Published: March 2023

We present the case of a 49-year-old man who was diagnosed with depressive disorder, with the first episode having a strong reactive factor. He was involuntarily admitted to a psychiatric hospital after a failed attempt at taking his own life, where he responded to psychotherapy and antidepressant therapy, as evidenced by a >60% reduction in his MADRS total score. He was discharged after 10 days of treatment, denied having suicidal ideations, and was motivated to follow the recommended outpatient care. The risk for suicide during hospitalization was also assessed using suicide risk assessment tools and psychological assessments, including projective tests. The patient underwent a follow-up examination with an outpatient psychiatrist on the 7th day after discharge, during which the suicide risk assessment tool was administered. The results indicated no acute suicide risk or worsening of depressive symptoms. On the 10th day after discharge, the patient took his own life by jumping out of the window of his flat. We believe that the patient had dissimulated his symptoms and possessed suicidal ideations, which were not detected despite repeated examinations specifically designed to assess suicidality and depression symptoms. We retrospectively analyzed his quantitative electroencephalography (QEEG) records to evaluate the change in prefrontal theta cordance as a potentially promising biomarker of suicidality, given the inconclusive results of studies published to date. An increase in prefrontal theta cordance value was found after the first week of antidepressant therapy and psychotherapy in contrast to the expected decrease due to the fading of depressive symptoms. As demonstrated by the provided case study, we hypothesized that prefrontal theta cordance may be an EEG indicator of a higher risk of non-responsive depression and suicidality despite therapeutic improvement.
Cooperative leadership as a condition for patient-reported rehabilitation success
Authors: Meyer Thorsten , Kleineke Vera , Stamer Maren
Published: March 2023

Introduction

Rehabilitation is a complex intervention that takes place in a complex setting. The MeeR project (characteristics of successful rehabilitation facilities) aims to identify complex conditions of successful rehabilitation outcomes.

Methods

A project with a sequential mixed-methods study design with a quantitative prestudy and a qualitative main study was applied. In the quantitative study, quality assurance data of the German Pension Insurance was used to (1) develop and compute a multifacet z-standardized outcome index based on patient-reported outcome data, (2) rank k = 273 orthopedic rehabilitation facilities comprising n = 112,895 patients and k = 86 cardiac rehabilitation institutions comprising n = 30,299 patients based on their outcome index score by means of a league table, and (3) adjust the ranking by basic patient characteristics (age, gender, diagnosis, weeks out of work prior to rehabilitation, application for pension). In the qualitative main study, k = 6 rehabilitation facilities (orthopedic and cardiac rehabilitation centers) were recruited based on the results of the quantitative analysis: three facilities that ranked top 10% and three facilities that ranked lowest 10% of the adjusted league table. All six rehabilitation facilities were visited each for 1 week by two researchers. We conducted participant observations, expert interviews with medical and administrative leaders, group discussions with rehab team members, and group discussions with patients. Subsequently, a systematic comparison of the results of the upper and lower 10% facilities was conducted to identify those characteristics that distinguished those institutions from one another.

Results

One of the three clusters of characteristics that distinguished the above and below 10% facilities related to teamwork or interdisciplinary cooperation: among others, the extent of interdisciplinary cooperation was higher in the rehabilitation facilities with a higher degree of success, the leading medical doctors were less dominant in these institutions, and there was also a more comprehensive representation of the team within team meetings, i.e., the quality and amount of interdisciplinary cooperation were higher in these institutions compared to rehabilitation facilities with a lower level of success.

Discussion

This project provided qualitative evidence for the role of interdisciplinary cooperation and collaborative leadership and its different facets for patient-related successful rehabilitation in orthopedic and cardiac rehabilitation. It provides valuable insights into the fabric and structure of a rehabilitation institution and a variety of target points for team development and group-leading interventions.
Dibasic Magnesium Hypochlorite as an Oxidant to Tune Pasting Properties of Potato Starch in One Step
Authors: Broekman J. O. P. , Dijkhuis Brian W. , Thomann Johanna A. , Heeres André , Heeres Hero J. , Deuss Peter J.
Published: March 2023

Modified starches are used widely in the food industry but often have a low nutritional value, lacking minerals vital for the human body, such as magnesium. Magnesium addition to native starches has been shown to result in changes in pasting properties. However, little work has been done on the addition of magnesium and other divalent cations to highly oxidised starches. In this work, we used dibasic magnesium hypochlorite (DMH) to oxidise potato starch to an industrially relevant degree of oxidation while at the same time introducing magnesium into the starch structure. We found that magnesium incorporation changes the pasting properties of starch and increases the gelatinisation temperature significantly, possibly due to an ionic cross-linking effect. These properties resemble the properties found for heat-moisture-treated potato starches. This change in properties was found to be reversible by performing a straightforward exchange of metal cations, either from sodium to magnesium or from magnesium to sodium. We show in this work the potential of the addition of divalent cations to highly oxidised starches in modifying the rheological and pasting properties of these starches and at the same time adding possible health benefits to modified starches by introducing magnesium.
Preparation of V2O5 Thin Film by Sol–Gel Technique and Pen Plotter Printing
Authors: Gorobtsov Philipp Yu. , Simonenko Tatiana L. , Simonenko Nikolay P. , Simonenko Elizaveta P. , Kuznetsov Nikolay T.
Published: March 2023

The work is dedicated to study of thin V2O5 film formation by pen plotter printing using vanadyl alkoxyacetylacetonate as hydrolytically active precursor. Solution of the prepared vanadyl butoxyacetylacetonate complex with 87% of butoxyl groups was used as functional ink for pen plotter printing of thin V2O5 film on surface of specialized chip. According to atomic force microscopy (AFM) and scanning electron microscopy (SEM), oxide film consists of nanorods 35–75 nm in thickness and 120–285 nm in length, with crystallite size of 54 ± 4 nm. Data from Rietveld refinement of the X-ray powder diffraction results and work function value (4.54 eV) indicate high content of defects (such as oxygen vacancies) in the material. Electrophysical properties study suggests that correlated barrier hopping of the charge carriers is the main conductivity mechanism. Conductivity activation energy Ea was found to be 0.24 eV.
TKGQA Dataset: Using Question Answering to Guide and Validate the Evolution of Temporal Knowledge Graph
Authors: Ong Ryan , Sun Jiahao , Șerban Ovidiu , Guo Yi-Ke
Published: March 2023

Temporal knowledge graphs can be used to represent the current state of the world and, as daily events happen, the need to update the temporal knowledge graph, in order to stay consistent with the state of the world, becomes very important. However, there is currently no reliable method to accurately validate the update and evolution of knowledge graphs. There has been a recent development in text summarisation, whereby question answering is used to both guide and fact-check summarisation quality. The exact process can be applied to the temporal knowledge graph update process. To the best of our knowledge, there is currently no dataset that connects temporal knowledge graphs with documents with question–answer pairs. In this paper, we proposed the TKGQA dataset, consisting of over 5000 financial news documents related to M&A. Each document has extracted facts, question–answer pairs, and before and after temporal knowledge graphs, to highlight the state of temporal knowledge and any changes caused by the facts extracted from the document. As we parse through each document, we use question–answering to check and guide the update process of the temporal knowledge graph.
Premature Cardiovascular Misdiagnosis of Senior Endurance-Trained Athletes
Authors: Jackson John K.
Published: March 2023

A mature Caucasian patient, an endurance-trained triathlete (age group), had a routine ECG. The patient was immediately referred to Emergency based on supposed ECG abnormalities indicating a heart attack. This diagnosis was quickly dismissed based on no symptoms, heart rate of 50 BPM, athletic status, excellent health, and no prior cardiovascular problems. The patient had a history of severe white coat hypertension and underwent a further stress test and echocardiogram. The stress test showed exaggerated systolic blood pressures (over 225 mmHg) and high in-clinic basal blood pressures (160/90 mmHg), and the patient was diagnosed as hypertensive with exercise blood pressure close to stroke territory. He was told to stop racing, reduce training, and was prescribed antihypertensive drugs (which he did not take). Subsequent at-home 24 h (values close to 120/80 mmHg) and stress blood pressure measurements reversed that decision when considered in combination with an excellent echocardiogram result. The literature clearly describes endurance-trained athletes with systolic pressures over 225 mmHg Hg as being conditioned with no pathological aspects. Endurance-trained athletes should be examined as special cases in the field of cardiovascular medicine as trained physiological responses often present as cardiac abnormalities, and misdiagnosis can inappropriately change the athlete’s life.
Prevalence of Anemia and Iron Deficiency in Women of Reproductive Age in Cuba and Associated Factors
Authors: Pita-Rodríguez Gisela María , Basabe-Tuero Beatriz , Díaz-Sánchez María Elena , Alfonso-Sagué Karen , Gómez Álvarez Ana María , Montero-Díaz Minerva , Valdés-Perdomo Sonia , Chávez-Chong Cristina , Rodríguez-Martinez Ernesto , Díaz-Fuentes Yoandry , Llera-Abreu Elisa , Calzadilla-Cámbara Ahindris , Ríos-Castillo Israel
Published: March 2023

This study aims to evaluate the prevalence of anemia and iron deficiency in women of reproductive age and the association with inflammation, global overweight, adiposity, and menorrhagia. A sample design of women of reproductive age from the Eastern, Central, and Havana Regions was carried out. Biochemical determinations of hemoglobin, serum ferritin, soluble transferrin receptors, leukocytes, C-reactive protein, alpha-1 acid glycoprotein, and homocysteine were performed. Serum ferritin was also adjusted by inflammation. Nutritional status was assessed, and menstrual characteristics were collected by survey. A total of 742 women were studied. The prevalence of anemia was 21.4%, iron storage deficiency at 16.0%, and erythropoietic dysfunction at 5.4%, with inflammation at 47.0% and elevated homocysteine at 18.6%. Global overweight was 46.2% and increased adiposity at 58.4%. Anemia is associated with iron deposition deficiency (OR = 3.023 (1.816–5.033)) and with erythropoietic deficiency (OR = 5.62 (3.03–10.39)), but not with inflammation, global overweight, and adiposity. Global overweight was found to be associated with inflammation (OR = 2.23 (1.41–3.53)). Anemia was associated with heavy menstrual bleeding (OR = 1.92 (1.34–2.76)). Homocysteine was associated with inflammation (OR = 2.05 (1.08–3.90)), but not with anemia. In conclusion, anemia in Cuba is classified as a moderate public health problem, but not iron deficiency. A high prevalence of overweight and obesity was found, associated with inflammation, but not with anemia or iron deficiency. Heavy menstrual bleeding is a factor associated with anemia.
Changes Caused by Bisphenols in the Chemical Coding of Neurons of the Enteric Nervous System of Mouse Stomach
Authors: Makowska Krystyna , Gonkowski Slawomir
Published: March 2023

Bisphenol A (BPA), an organic chemical compound which is widely used in the production of plastics, can severely damage live organisms. Due to these findings, the plastic industry has started to replace it with other substances, most often with bisphenol S (BPS). Therefore, during the present investigation, with the use of double immunofluorescence labeling, we compared the effect of BPA and BPS on the enteric nervous system (ENS) in the mouse corpus of the stomach. The obtained results show that both studied toxins impact the amount of nerve cells immunoreactive to substance P (SP), galanin (GAL), vesicular acetylcholine transporter (VAChT is used here as a marker of cholinergic neurons) and vasoactive intestinal polypeptide (VIP). Changes observed under the impact of both bisphenols depended on the neuronal factor, the type of the enteric ganglion and the doses of bisphenols studied. Generally, the increase in the percentage of neurons immunoreactive to SP, GAL and/or VIP, and the decrease in the percentage of VAChT-positive neurons, was noted. Severity of changes was more visible after BPA administration. However, the study has shown that long time exposure to BPS also significantly affects the ENS.
The Impact of the Implementation of International Law on Marine Environmental Protection on International Public Health Driven by Multi-Source Network Comment Mining
Authors: Yang Anqi , Yang Shudong
Published: March 2023

With the increase of people’s living space, global warming caused by the decrease of greening urban spaces and the serious decline of greenspace quality has led to extreme weather events and coastal erosion, which has become the biggest threat to the ocean and has also led to the occurrence of international public safety incidents. Therefore, it is of great practical significance to explore the tense relationship between the current marine environmental protection and global public safety for the development of an international healthy community. Firstly, this paper discusses the influence of implementing the international law of marine environmental protection on global public health after the reduction of green urban space and the decline of green space quality. Secondly, K-means and discrete particle swarm optimization algorithms are introduced and the particle swarm optimization-K-means clustering (PSO-K-means) algorithm is designed to screen and deal with the mapping relationship between latent variables and word sets about the impact of implementing the international marine ecological protection law on the international public health community in network data information. Moreover, the influencing factors are clustered and the scenarios are evaluated. The results show that the clustering analysis of the marine environment can promote the clustering of marine characteristic words. Meanwhile, the PSO-K-means algorithm can effectively cluster vulnerability data information. When the threshold is 0.45, the estimated recall rate of the corresponding model is 88.75%. Therefore, the following measures have been formulated, that is, increasing greening urban spaces and enhancing the quality of green space to enhance the protection of marine environment, which has practical reference value for realizing the protection of marine environment and the sustainable development of marine water resources and land resources.
Nicotine Dependence among College Students Uninterested in Smoking Cessation during the COVID-19 Pandemic: A Cross-Sectional Survey
Authors: Aoike Makoto , Mori Yukihiro , Aoyama Yuka , Tanaka Mamoru , Kozai Hana , Shigeno Yukihiro , Kawamura Hatsumi , Tsurudome Masato , Ito Morihiro
Published: March 2023

This study investigated nicotine dependence among Japanese university students who had reached the smoking age (20 years or older) by the time of the coronavirus disease 2019 (COVID-19) pandemic and examined factors that encourage early smoking cessation. Social dependence on nicotine was evaluated using the Kano Total Social Nicotine Dependence Level (KTSND), and physiological dependence was evaluated using the Fagerström Nicotine Dependence Index (FTND). Of the 356 college students who smoked (4.4% of the total), 182 (51.1%) stated that they were not interested in quitting. Furthermore, 124 (68.1%) of those with no interest in quitting smoking were aware that smoking is a high-risk factor for COVID-19, and 58 (31.9%) were unaware. The group not aware of this risk had significantly higher KTSND scores than the group aware of it. The examination of cigarette type that indicated the users of non-conventional cigarette products and dual-user groups scored significantly higher than the cigarette group on FTND items. Overall, the smokers scored above the normal range for social nicotine dependence, suggesting the need to reduce nicotine dependence to encourage college students who continue to smoke to quit smoking.
Demonstrating the Test Procedure for Preventive Maintenance of Aging Concrete Bridges
Authors: Kim Hyun-joong , Seong Yeong-hun , Han Jong-wook , Kwon Seung-hee , Kim Chul-young
Published: March 2023

Deteriorated facility maintenance is a critical social issue in advanced countries. Its cost increases when considering the social consequences in terms of asset value and direct maintenance costs. Data from Korea’s Ministry of Land, Infrastructure, and Transport shows that there were 3454 bridges aged 30 years or over in Korea in 2017; this number will increase to 10,961 by 2027. In thirty years, maintenance costs will be incurred for more than 32,000 old bridges in Korea. These trends are also observed in the US, Japan, and Korea. Diverse studies have been conducted to predict the residual life of old bridges via bridge performance evaluation and load-carrying capacity assessments. However, criteria for evaluating bridge performance and verifying the effect of bridge maintenance are yet to be established due to two reasons. First, most studies on performance evaluation, maintenance, and rehabilitation techniques have been performed on limited specimens from building elements or through small-scale simulations that do not reflect the deterioration factors of complex materials in diverse environments. Second, the performance evaluation of bridges is difficult compared to quantitative state evaluations. As a method of predicting the future performance of aged concrete bridges, it is effective to understand the actual aged bridges through experiments, and this study intends to propose the method.
The Connection between Immunocompetence and Reproduction in Wildlife
Authors: Stope Matthias Bernhard
Published: March 2023

Reproduction rate is important for the survival of animal populations. During gravidity, a trade-off occurs between the individual well-being of gravid females and investment in offspring. Due to the high synthesis and energy requirements for the growing fetus, other physiological activities are downregulated in pregnant females. This causes changes in the composition of the reproductive microbiome and a decreased immune response to presented antigens and pathogens. As a result, the immunocompetence of gravid wild animals declines. In general, therefore, increased infection rates during pregnancy can be observed in all wildlife species studied. In the course of evolution, however, this has apparently evolved as a suitable strategy to ensure the survival of the population as a whole.
The Calibration Methods of Geometric Parameters of Crystal for Mid-Infrared Acousto-Optic Tunable Filter-Based Imaging Systems Design
Authors: Yu Kai , Guo Qi , Zhao Huijie , Cheng Chi
Published: March 2023

AOTF calibration is a complex topic that has various aspects. As far as geometric calibration is concerned, it includes not only processing errors and fixing errors in the optical system, but also the error of geometric parameters of crystal (GPC). GPC is the preset input in the optical design and optimization of Zemax, which determines the key parameters, including the spatial resolution, the field of view, and aberration. In particular, the compensation of aberration during the optical design requires accurate values of GPC. However, it is currently considered ideal. Therefore, two calibration methods based on the principle of parallel tangent are proposed: (1) the minimum-central wavelength method; (2) the minimum-frequency method. The deviation of the parallel tangent incident angle calibrated by the two methods is 0.03°. As a result, the tuning curve calculated in theory with the calibrated geometric parameters of AOTF is consistent with the tuning curve measured in practice.
Enhanced Desulfurization by Tannin Extract Absorption Assisted by Binuclear Sulfonated Phthalocyanine Cobalt Polymer: Performance and Mechanism
Authors: Wang Bing , Chen Huanyu , Hao Xingguang , Li Kai , Sun Xin , Li Yuan , Ning Ping
Published: March 2023

Removal of hydrogen sulfide (H2S) from coke oven gas has attracted increasing attention due to economic and environmental concerns. In this study, tannin extract (TE) absorption combined with binuclear sulfonated phthalocyanine cobalt organic polymer (OTS) and binuclear sulfonated phthalocyanine cobalt (PDS) with a fixed bed reactor is used for removal of H2S. The effect of gas flow rate, concentration of H2S, co-existence of organic sulfide compounds and O2 were investigated. Then, the effect of total alkalinity content of TE, NaVO3, OTS and PDS was studied in detail. The experimental results demonstrated that 100% H2S conversion could maintain for 13 h at a total alkalinity of 5.0 g/L, TE concentration of 4.0 g/L, NaVO3 concentration of 5 g/L, and OTS and PDS concentration of 0.2 g/L and 0.2 g/L, respectively. The OTS and PDS showed synergistic effect on boosting TE desulfurization efficiency. The results provide a new route for the investigation of liquid catalyzed oxidation desulfurization in an efficient and low-cost way.
Advanced Electronic Packaging Technology: From Hard to Soft
Authors: Gu Yue , Huo Yongjun
Published: March 2023

Packaging is a pivotal step in electronic device manufacturing, determining the translational performance of bare chips [...]
Optimization Design of the Bending-Vibration Resistance of Magnetorheological Elastomer Carbon Fibre Reinforced Polymer Sandwich Sheets
Authors: Wang Guangbin , Yan Yangyang , Wang Wenyu , Li Zelin , Zhang Zhengwei , Sun Zhanbin , Qiao Zhou , Li Jinan , Li Hui
Published: March 2023

An optimization design of the bending-vibration resistance of magnetorheological elastomer carbon fibre reinforced polymer sandwich sheets (MECFRPSSs) was studied in this paper. Initially, by adopting the classical laminate theory, the Reddy’s high-order shear deformation theory, the Rayleigh-Ritz method, etc., an analytical model of the MECFRPSSs was established to predict both bending and vibration parameters, with the three-point bending forces and a pulse load being considered separately. After the validation of the model was completed, the optimization design work of the MECFRPSSs was conducted based on an optimization model developed, in which the thickness, modulus, and density ratios of magnetorheological elastomer core to carbon fibre reinforced polymer were taken as design variables, and static bending stiffness, the averaged damping, and dynamic stiffness parameters were chosen as objective functions. Subsequently, an artificial bee colony algorithm was adopted to execute single-objective, dual-objective, and multi-objective optimizations to obtain the optimal design parameters of such structures, with the convergence effectiveness being examined in a validation example. It was found that it was hard to improve the bending, damping, and dynamic stiffness behaviours of the structure simultaneously as the values of design variables increased. Some compromised results of design parameters need to be determined, which are based on Pareto-optimal solutions. In further engineering application of the MECFRPSSs, it is suggested to use the corresponding design parameters related to a turning point to better exert their bending-vibration resistance.