bluuebunny/crossref_metadata_2025 huggingface dataset:
Breaks of the secular in modern culture: manifestation of homo religiosus
Authors:   Volgograd State University, Spirin T.V.
Published: March 2023

The article considers with the breaks of the secular in modern culture. The debatability of the concept of «religion» is described, and also the productivity of using the concept of «dispositive of faith». The idea of homo religiosus as a special mode, manifested in the existence of modern man, is considered. Modern rituals that testify to the breaks of the secular are investigated. Possible alternatives to the religiosus worldview are demonstrated.
History of the Catholic Mission in Mongolia since 1992
Authors:   Independent Researcher, Terentyev V.I.
Published: March 2023

Mostly on the basis of personal observation and conversations with Catholic ecclesiastic, a picture of the missionary activity of the Roman Catholic Church (RCC) in modern Mongolia is built. The historical period in the Mongolian Catholic History, starting from 1992, is designated as the «new era». Significant achievements of Catholics in the field of social service are noted. Quantitative data of the RCC in Mongolia are given. As a result, the main problems faced by Catholic missionaries in Mongolia are indicated.
FORMATION OF A MODERN MODEL OF LABOR PROTECTION USING THE "BLACK BOX" METHOD
Authors:   All-Russian Scientific Research Institute of Labor, Moscow, Russia, Samarskaya N.A.
Published: March 2023

The purpose of the study is to form a model of labor protection in its transformation, based on the use of a universal method of intelligent circuitry "black box". The scientific novelty of the research consists in substantiating the need to obtain new knowledge to develop the scientific theory of labor protection as a controlled system, influencing external and internal factors in which it is possible to find effective modes of its functioning, development, and transformation. The result of the study is a formed model of labor protection in the process of its change in the conditions of the modern economy, with certain input resources and output indicators that determine the effectiveness of the process under study. The author concludes that the research results expand the scientific understanding of the processes occurring in the labor protection system when exposed to external environmental factors.
DIGITAL ECONOMY AND LABOR MARKET, DIGITAL TECHNOLOGIES AND LABOR RELATIONS: MUTUAL INFLUENCE, FEATURES AND DEVELOPMENT TRENDS
Authors:   Ministry of Justice of the Russian Federation, Moscow, Russia, Vukolov V.L.
Published: March 2023

The subject of the research is digital technologies that are increasingly being used in the main processes of the organization of the labor market and in the implementation and registration of labor relations. The purpose of the study is to analyze the expansion of the use of information technologies in the field of labor and the promotion of employment. The relevance of the research is due to the need for a legal and regulatory framework of new forms of consolidation of labor relations arising in connection with the use of digital and information technologies, the transfer of the main processes that determine labor market relations into an electronic format and the accelerated development of new forms of employment, including self-employed, remote work, freelance. The scientific novelty consists in the systematization of the main trends of changes in the nature of the interaction between employees and employers under the influence of key information technologies in the current labor market. The research methods include analysis, systematization, synthesis, induction, and deduction. The study concludes that as the processes aimed at building a digital economy grow and expand, the format of relations between employees and employers changes significantly, which requires the consolidation of efforts of all participants in social and labor relations and the timely development of the necessary tools of digital public administration provided with new forms of legal regulation of changing and emerging legal relations.
MODERN MIGRATION FLOWS IN THE POST-SOVIET SPACE
Authors:   Primakov National Research Institute of World Economy and International Relations, Russian Academy of Sciences, Moscow, Russia, Komarovsky V.V.
Published: March 2023

The subject of the study is the trends and prospects for the development of national migration flows in the post-Soviet space in modern conditions. The purpose of the paper is to identify the degree of stability of the migration flows that have formed in the post- Soviet space now under the influence of a series of unforeseen circumstances. The relevance of the study is due to the growing impact of unforeseen and massive natural and political phenomena on migration flows as the main drivers of cross-border mobility. The research methods are analysis, systematization, synthesis, and classification of the objects under study. The study attempts to assess the impact of the pandemic and recent political upheavals on the scale of migration to Russia. The author concludes that the current migration system within the CIS countries has demonstrated a high level of stability and resilience. The practical interest of the study is determined by the possibility of using the research data for the purposes of forecasting and planning the scale and structure of attracting foreign labor to Russia.
REPRODUCTION OF QUALIFIED PERSONNEL: PROBLEMS, TRENDS, PROSPECTS
Authors:   Academy of Labor and Social Relations, Moscow, Russia, Kyazimov K.G.
Published: March 2023

The subject of the study is the reproduction of qualified personnel. The aim of the paper is to develop proposals for the reproduction of skilled workers and specialists. The main research methods are systematic and comparative analysis, expert surveys, and pedagogical experiments. The theoretical significance of the article lies in the fact that as a result of the research, new and additional scientific knowledge and methods of reproduction of highly qualified personnel have been obtained, and scientific and practical recommendations have been developed for the gradual formation of the competence of graduates of professional educational organizations, a model for the ascent of young specialists to professional competence has been formed. The practical significance of the research results lies in their use in professional educational organizations and in the system of in-house training of personnel.
Ixazomib for Desensitization (IXADES) in Highly Sensitized Kidney Transplant Candidates: A Phase II Clinical Trial
Authors: Wilson Nancy , Reese Shannon , Ptak Lucy , Aziz Fahad , Parajuli Sandesh , Jucaud Vadim , Denham Shari , Mishra Ameet , Cascalho Marilia , Platt Jeffrey L. , Hematti Peiman , Djamali Arjang
Published: March 2023

Background:

Ixazomib is a second-generation oral proteasome inhibitor approved for treatment of refractory multiple myeloma. We conducted an open label phase II trial, IXADES (IXAzomib for DESensitization) testing safety of Ixazomib treatment as an approach to decreasing the level and diversity of specificities of anti-HLA antibodies in subjects awaiting kidney transplantation. The trial (NCT03213158) enrolled highly sensitized kidney transplant candidates, defined as subjects with calculated panel reactive antibodies (cPRA) >80%, awaiting kidney transplantation >24 months. The subjects were treated with 12 monthly cycles of ixazomib 3 mg + dexamethasone 20 mg. Efficacy was defined as a decrease of cPRA >20% or kidney transplantation. The safety endpoint was tolerability.

Methods:

In 10 enrolled subjects, no grade IV, five grade III, 11 grade II, and 43 grade I adverse events were noted. The adverse events included infection, transient paresthesia, nausea, vomiting, and diarrhea. The IXADES regimen was not associated with significant change in levels or diversity of anti-HLA antibodies (cPRA).

Results:

Although the IXADES regimen did not exhibit a clear impact on levels and diversity of anti-HLA antibodies in this small cohort, the prolonged half-life of IgG could necessitate a longer duration of treatment for accurate evaluation of efficacy.

Conclusions:

In conclusion, treatment with ixazomib/dexamethasone engendered mild to moderate toxicity. The impact on anti-HLA was modest and in the case of anti-HLA-DR paradoxical. Clinical trials combining ixazomib with other immunosuppressive agents may be more effective in addressing antibody-mediated processes in kidney transplantation.
Nörofibromatozis Tip1’li Olgularda NF1 Geni Varyant Spektrumu: Tek Merkez Deneyimi
Authors: GERİK CELEBİ Hamıde Betul , BOLAT Hilmi , DOKUREL İpek , DEMİRAL Meliha , ÇAM Sırrı
Published: March 2023

Giriş ve Amaç: Nörofibromatozis tip 1 başlıca cafe au lait lekeleri, Lisch nodülleri ve nörofibromlarla karakterize otozomal dominant kalıtımlı bir rasopatidir. Bu çalışmada amacımız, NF1 ön tanısıyla başvuran hastaların genotipik verilerini sunmaktır.

Gereç ve Yöntemler: 2018 Haziran–2022 Haziran tarihleri arasında yaş ortalaması 8,1 yaş (2 ay-28 yaş aralığında) olan 22 olgu NF1 ön tanısıyla değerlendirildi. Hastalara NF1 geni dizi analizi yapıldı.

Bulgular: NF1 geni dizi analizi yöntemiyle tanı oranı %90,9 idi. 16 farklı NF1 geni varyantından 13 (%81,25) 'ü patojenik/muhtemel patojenik iken, 3 (%18,75)'ü ise klinik önemi bilinmeyen varyantlardı.

Sonuç: NF1 ön tanısıyla başvuran hastalardaki genetik tanı oranı ve klinik bulguları literatür verileri eşliğinde tartışıldı. 4 yeni NF1 geni varyantı saptandı.
Use of Customized Thickness Anterolateral Thigh Flap in Head and Neck Reconstruction
Authors: ÖZKAYA ÜNSAL Merve , TULUY Yavuz , BALİ Zülfükar Ulaş , PARSPANCI Aziz
Published: March 2023

Objective: This study demonstrates different techniques of anterolateral thigh flap (ALT) with the appropriate surgical planes according to the thickness of the defect, which have not been previously found in the literature, with our reconstruction experiences.

Materials and Methods: A retrospective study was performed including 26 flaps in 25 patients who underwent reconstruction of head and neck defects with different surgical planes of ALT flap including subfascial, superthin, suprafascial, chimeric and composite flaps from March 2017 through December 2020. Flap planes were chosen according to the thickness of the defect, determined during surgery by using caliper. We evaluated the characteristics, flap thicknesses, complications and need of revision surgery in postoperative period.

Results: One of the superthin flaps was totally lost; there was not any other flap loss. Three patients died in postoperative period. Although appropriate plane of the flaps was chosen, 4 of all 26 flaps needed revision surgery. One of the patients who was performed lip reconstruction with superthin ALT flap had bulky appearance needed liposuction in postoperative 6 months and 3 patients who received subfascial ALT flaps were performed debulking surgeries.

Conclusion: ALT flap is a versatile, reliable flap which can be harvested in different planes according to the thickness of the defect in head and neck region. The ALT flap with convenient thickness provides definitive reconstruction in a single stage without revision surgeries and the most optimal aesthetic results can be obtained.
Pemberdayaan Orang Tua Remaja dalam Meningkatkan Kemampuan Parenting dan Penerapan Fungsi Keluarga di BKR Kelurahan Bandar Lor
Authors: Sejati Putri Eka , Suhita Byba Melda
Published: March 2023

Latar Belakang: World Health Organization (WHO) mendefinisikan remaja adalah individu berusia 10-19 tahun yang merupakan masa transisi dimana mereka sering mengalami berbagai masalah salah satunya adalah kehamilan remaja yang memiliki dampak buruk baik secara fisik, psikologis, dan sosial. Keluarga merupakan tempat pertama dalam perkembangan remaja baik secara fisik maupun sosial sehingga pentingnya kemampuan orang tua dalam pengasuhan remaja sesuai dengan fase perkembangannya sedangkan Fungsi Keluarga adalah kualitas hubungan antara orang tua dan remaja. Tujuan dalam pengabduan masyarakat ini adalah untuk meningkatkan pengetahuan orang tua yang memiliki anak remaja dalam pengasuhan dan penerapan fungsi keluarga. Metode: Pengabdian masyarakat ini menggunakan metode problem solving dalam proses pemberdaan ibu yang memiliki anak remaja, dilakukan pre test sebelum pemberdayaan dan post test setelah pemberdayaan. Hasil dan Pembahasan: terdapat peningkatan pengetahuan mengenai pola asuh dan fungsi keluarga dari orang tua remaja antara sebelum dan sesudah pemberdayaan. Didapatkan hasil sebesar 47,1 % ibu remaja berpengetahuan kurang sebelum pemberdayaan menjadi 70,5% berpengetahuan baik setelah pemberdayaan. Pentingnya pengetahuan orang tua mengenai pola asuh dan penerapan fungsi keluarga diharapkan orang tua mampu memberikan pendidikan seksual kepada remaja sehingga bisa mencegah perilaku seksual beresiko.
Prospective Teachers’ Metaphorical Perceptions of "School, Teacher, Principal and Superintendent"
Authors: GÖKTAŞ Erkan
Published: March 2023

Research on prospective teachers' perceptions and descriptions of the essential education

concepts helps to determine their educational viewpoint before starting the profession. In

this study, it is aimed to reveal and analyse the metaphorical perceptions of prospective

teachers about the concepts of school, teacher, principal, and superintendent. The study is

planned in a basic qualitative research design. Participants of the study were 95 students

attending to Selcuk University in the 2021-2022 academic year. Participants were recruited

by using convenience sampling. Data were collected by using an open-ended questionnaire

form and were analysed by content analysis technique. A total of 358 metaphors related to

the concepts of school, teacher, principal, and superintendent were produced by teacher

candidates. Of these, 91 were related to schools, 103 to teachers, 89 to principals and 75 to

superintendents. Findings showed that the metaphors reflect both positive and negative

perceptions about the concepts. Prospective teachers often used positive metaphors for

the concept of school, teacher, and principal. However, it was noted that the metaphors

reflecting negative connotations for the concept of superintendent were relatively more.
Investigation of the Human Maxilla and Mandible Trabecular Microstructure with Micro-Computed Tomography
Authors: SOYSAL Handan , GENECİ Ferhat , OCAK Mert
Published: March 2023

ÖZ
Amaç: Maksilla ve mandibulanın trabeküler mikromimarisini mikrobilgisayarlı tomografi (mikro-BT) kullanarak değerlendirmek.
Materyal ve metod: Yirmi adet maksiller ve mandibula kadavra örneği, mikro BT kullanılarak tarandı. Numuneler Skyscan 1275® micro-CT sistemi (SkyScan, Kontich, Belçika) kullanılarak aşağıdaki parametrelerle tarandı. Tarama verileri CTan yazılımına aktarıldı ve analiz edildi. Morfometrik parametreler; doku hacmi (DH), Kemik hacmi (KH), kemik hacmi yüzdesi (KH/DH), doku yüzeyi (DY), kemik yüzeyi (KY), kesişme yüzeyi (KY), kemik yüzeyi/hacim oranı (KY/KH), kemik yüzey yoğunluğu (BS/TV), trabeküler patern faktörü (Tb.Pf), yapı modeli indeksi (YMI), trabeküler kalınlık (Tb. Th), trabeküler ayrılma (Tb. Sp), trabeküler sayı (Tb.N) ve anizotropi derecesi (DA), CTAnalyzer yazılımı kullanılarak değerlendirildi. İstatistiksel anlamlılık p<0.05 olarak ayarlandı.
Bulgular: BV/TV, Tb.Th, Tb. KIBT görüntülerinde Sp ve DA değerleri mikro-BT görüntülerine göre daha yüksek iken, Tb. CBCT görüntülerinde N değeri, mikro BT görüntülerinden daha düşüktü. BV/TV ve DA parametreleri, CBCT ve mikro-CT cihazları arasında en yüksek uyumu gösterdi (BV/TV için ICC=0,421 ve DA için ICC=0,439, p<0,01).
Sonuç: En küçük voksel boyutunda elde edilen CBCT'de ölçülen BV/TV ve DA parametrelerinin maksiller trabeküler mikroyapının değerlendirilmesinde yararlı olduğu bulundu.
Anahtar Kelimeler: Mikro bilgisayarlı tomografi, trabeküler kemik mikro yapısı, Maxilla, Mandibula.
Terapia intermitente con vismodegib para el CBC avanzado: experiencia en un centro de referencia oncológico en Colombia
Authors: Pulido Prieto Leonardo , Ospina Delgado María Angélica , Jaimes Ramirez Ángel Omar , Carreño José Alexander
Published: March 2023

Objetivo: Describir los desenlaces clínicos de los pacientes con Carcinoma basocelular avanzado (CBCa), tratados con vismodegib, en el servicio de dermatología oncológica del Instituto Nacional de Cancerología (INC), entre junio de 2014 y enero de 2020.
Métodos: Se realizó un estudio observacional retrospectivo tipo serie de casos. Las variables clínicas, histopatológicas, de tratamiento y respuesta clínica se presentan en tablas y se describen mediante medidas de frecuencia absoluta y relativa para las variables cualitativas y medidas de tendencia central para las variables cuantitativas.
Resultados: Se analizaron 55 pacientes con una mediana de 9 ciclos de vismodegib y de 18 meses de duración de tratamiento. 34 pacientes (61,8%) suspendieron el tratamiento en el 21,8% de los casos debido a progresión de la enfermedad. Se obtuvo una respuesta clínica objetiva en el 80%, con respuesta completa del 41,8% y parcial en el 38,2%. Se documentaron efectos adversos en 53 pacientes (96,4%); los tipos más frecuentes fueron calambres en el 76,3%, disgeusia en el 63,6% y pérdida de peso en el 54,5%. La graduación de esos efectos adversos fue predominantemente grado 1 y 2, obteniendo grado 3 en un 8,4% de los casos y ningún caso en grado 4.
Conclusiones: Se presenta una serie de casos de pacientes con CBCa que reciben un esquema de dosificación intermitente con Vismodegib, observando unas tasas de respuesta objetiva comparable a las reportadas en estudios prospectivos, con un perfil de seguridad favorable con menores tasas de efectos adversos de alto grado y suspensión del tratamiento por esta causa.
La evolución de la medicina nuclear: el reconocimiento de una especialidad relegada
Authors: Varela Ramírez Humberto
Published: March 2023

La evolución humana comenzó aproximadamente hace 6 millones de años, a partir de la especie Ardipithecus que habitaba en los bosques húmedos de África, continuando como género Homo con el Homo habilis y llegando hasta nuestros días, a nosotros, como Homo sapiens.
La evolución de la medicina nuclear ha sido progresiva, así como la de nuestra especie, obviamente no tan lenta (la evolución necesita tiempo para ir mejorando las funciones corporales para una mejor supervivencia y mantener la reproducción como meta para evitar la extinción), y en estas dos últimas décadas, mucho más. Desde que George Hevessy (1885-1966), considerado el padre de la medicina nuclear, en el año 1932 realizó investigaciones con el empleo de trazadores para marcar alimentos y valorar la trayectoria de estos dentro de los diferentes organismos, incluido el ser humano; esta especialidad médica ha desarrollado una tecnología sobresaliente, conocimientos que permiten diagnósticos y tratamientos novedosos utilizando el teranóstico, palabra acuñada por John Funkhouser, consultor de la empresa Cardiovascular Diagnosis, en agosto de 1998 (1, 2), para describir una herramienta que puede ser usada como diagnóstico, tratamiento y seguimiento a los pacientes. Este concepto ha evolucionado y abarca dos enfoques: una medicina personalizada para brindar una terapia dirigida dependiendo del perfil molecular del paciente, y el teranóstico como tal, en el cual están los biomarcadores y las imágenes que guían los diferentes procedimientos radiológicos, de radioterapia y de la medicina nuclear (1, 2).
Analisis Nilai Tambah Produk Pala Manis Hasil Usaha Wisma Bunaken Kelurahan Tona I Kecamatan Tahuna Timur Kabupaten Kepulauan Sangihe
Authors: Mare Lisa Lestari , Mandei Juliana Ruth , Tambas Jane Sulinda
Published: March 2023

The aim of this study was to calculate the added value of the “sweet nutmeg” product from the business of Wisma Bunaken in Tona I Village, Tahuna Timur District, Sangihe Archipelago Regency. The research was conducted from April to June 2022. The data used are primary data and secondary data. Primary data were obtained through direct interviews with company owners using prepared questionnaires and direct observation of conditions in the field during the analysis period. Secondary data, namely data obtained from the literature and literature through documents, publications, or research results from various institutions or institutions that support and relate to the required research topic. The results showed that 1 kilogram of nutmeg flesh processed by the Sweet Nutmeg Business of Wisma Bunaken, Tona I Village, Tahuna Timur District, Sangihe Islands Regency provided an added value of IDR 54,955 with a ratio obtained of 91.59 and a contribution of 18.20 workers and a additional packaging of IDR 14,955 for 100 gram packages and IDR 34,955 for 200 gram packages with ratios obtained of 0.74 and 0.87 for 100 and 200 gram packages.
Peran Penyuluh Pertanian Lapangan Pada Kelompok Tani Padi Sawah Teguh Bersinar Di Desa Kaneyan Kecamatan Tareran Kabupaten Minahasa Selatan
Authors: Pratasis Sutrika Marlina , Tambas Jane Sulinda , Sondakh Mex Frans Lodwyk
Published: March 2023

This study aims to find out and see how the role of field agricultural extension workers, especially in the lowland rice farmer groups in Kaneyan Village, Tareran District, South Minahasa Regency. The research was conducted in Kaneyan Village, Tareran District, South Minahasa Regency in July 2022. The data collection method was obtained from primary data through direct interviews using a questionnaire, and secondary data was obtained from agencies related to research and various literature that was in accordance with the research objectives. The sampling method in this research is purposive sampling (intentionally). Determination of the sample of 10 respondents who are the head of agricultural extension workers and the Teguh Bersinar rice field farmer group. The results of the study showed that the extension workers had carried out their duties properly. This can be seen from the majority of respondents who stated that extension agents had guided and facilitated farmers to be better.
Peranan Lembaga Penunjang Terhadap Pengembangan Agribisnis Stroberi Di Kabupaten Bolaang Mongondow Timur
Authors: Mambu Patricia Like , Loho Agnes Estephina , Sendow Martha Mareyke
Published: March 2023

This study aims to determine the supporting institutions for strawberry agribusiness, and the role of supporting institutions in the development of strawberry agribusiness in Mooat Village and South Bongkudai Village, East Bolaang Mongondow Regency. This research was conducted from May to August 2022. This research method uses a survey method. The research locations are all areas that grow strawberries. The data used in this study are primary data and secondary data. Primary data were obtained from respondents, namely farmers and institutions that support the development of strawberry agribusiness, namely agribusiness supporting institutions. Secondary data was obtained from the government, sub-district office, mooat village office, and literature studies. The sampling method used is multistage random sampling. Data analysis used in this research is descriptive analysis. The results showed that agribusiness supporting institutions in East Bolaang Mongondow Regency included Bank BRI, Bank SulutGo, BNI, and BPR, Savings and Loans Cooperatives, Producers Cooperatives, Consumer Cooperatives, Service Cooperatives, Multi-Business Cooperatives. Research and Technology Institutions in the form of Agricultural Vocational Schools, and Universities. Fisheries and Forestry Extension Center (F2EC), Production Facilities Agency.
Partisipasi Kelompok Tani Hijau Lestari Dalam Kegiatan Penyuluhan Pertanian Di Desa Tondei Satu Kecamatan Motoling Barat Kabupaten Minahasa Selatan
Authors: Bujung Venrando Chandra Putra , Maweikere Audrey Julia Maria , Baroleh Jenny
Published: March 2023

This study aims to determine the participation of the Green Lestari farmer group in agricultural extension activities in Tondei Satu Village, West Motoling District, South Minahasa Regency. This research started from April to June 2022. The data analysis method used in this study was descriptive analysis using a Likert Scale, the number of samples used in this study totaled 11 people. The types of data used in this research are primary data and secondary data. Primary data was obtained from direct interviews with the Hijau Lestari farmer group using a questionnaire, while secondary data was obtained from the Tondei Satu Village Government. The results of this study indicate that the participation of the Hijau Lestari farmer group in agricultural extension activities in Tondei Satu Village, West Motoling District, South Minahasa Regency is classified as active. Where is the total overall score of 353 with a percentage of 89.14.
Pendekatan Open Innovation Pada Usaha Virgin Coconut Oil (VCO) “Indococo” Oleh CV.Emka Indococo Sejahtera Di Kelurahan Sarongsong I Kecamatan Airmadidi Kabupaten Minahasa Utara
Authors: Tedjo Otniel Matheau Anggoro , Rengkung Leonardus Ricky , Tangkere Ellen Grace
Published: March 2023

This study aims to identify open innovation practice on SMEs with focus on CV. Emka Indococo Sejahtera that produce VCO “Indococo” located in Kecamatan Airmadidi on North Minahasa Regency. This study was conducted from August to November 2022. Using primary data by collected through interviews with inventor of VCO “Indococo” i.e. Prof. Dr. Ir. Lucia C. Mandey, MS and used secondary data collected through Google Scholar such as books, journal article and literature reviews. Identification results showed that open innovation has applied on CV. Emka Indococo Sejahtera as their business strategy. With their position on topdown, strategically-driven, distributed activities, open innovation practices by CV. Emka Indococo Sejahtera showed that their business activities as a strategy related to open innovation activities so there is an encouraged to developed and more exploration open innovation implementation as a strategy to survive in the market in the future.
Analisis Pemasaran Usaha Mikro Kecil Menengah Kerajinan Bambu Sebelum Dan Selama Covid-19 Di Warung Kenzo Kelurahan Kinilow Kecamatan Tomohon Utara Kota Tomohon
Authors: Tatuh Jusiana Veronika , Timban Jean Fanny Junita , Talumingan Celcius
Published: March 2023

This study aims to determine the benefits before and during the Covid-19 pandemic for Bamboo Crafts MSMEs at Warung Kenzo in the Kinilow Village, North Tomohon District, Tomohon City. This research was conducted from March to May 2022. The location of the research was carried out in the Kinilow Village, Tomohon Utara District, Tomohon City. The data in this study consisted of primary data and secondary data. The sampling method in this study was purposive sampling. The variables studied were the characteristics of the respondents, business characteristics, and the impact of the Covid-19 pandemic on income. The analytical method used in this study is a qualitative descriptive analysis method. The results of the study showed that the average profit of bamboo handicraft owners at Warung Kenzo before the co-19 pandemic was Rp.981,167/month and profits during the co-19 pandemic were Rp.10,442,500/month. This proves that Covid-19 has had a positive impact on micro, small and medium enterprises for bamboo handicrafts at Warung Kenzo in the Kinilow Village.
The improvement of Schottky barrier diodes fabricated only by B ion implantation doping accomplished by refinement of the electrode structure
Authors: Seki Yuhei , Chandra Saha Niloy , Shigematsu Seiya , Hoshino Yasushi , Nakata Jyoji , Oishi Toshiyuki , Kasu Makoto
Published: March 2023

In this study, we fabricated p-type diamond Schottky barrier diodes (SBD) and performed selective B doping for the p-type channel and Ohmic region by double ion implantation. SBD were redesigned in the configuration and shape of Ohmic and Schottky electrodes to improve device characteristics. The fabricated device exhibited a rectification ratio of approximately 2400 because of decreasing the parasitic resistance to 2.7 × 107 Ω and the ideality factor to 2.7. The Schottky barrier height was obtained to be 1.04 eV. It is indicated that the diamond SBD fabricated only by B ion implantation is improved by refinement of the electrode structure.
EVALUATION OF PANCYTOPENIA WITH BONE MARROW INTERPRETATION
Authors: Venkata Ramanababu P. , Taheer Hussain Bandimandhar
Published: March 2023

Background: Pancytopenia is one of the most common clinico-haematological entity observed in our
day to day clinical practice. It is a disorder in which all the three major elements of blood (i.e. red blood
cells, white blood cells and platelets) are decreased in number. The causes of pancytopenia may be due to decrease in
hematopoietic cell production in the marrow resulting from infections, toxins, malignant cell inltration, post- chemotherapy or
post-radiation.
Aims and Objectives:
1) To study the etiology and clinical presentation of pancytopenia in all age groups.
2) To correlate with bone marrow interpretation
Materials & Methods: This is a prospective study which was conducted among 50 patients of pancytopenia in the Clinical
Pathology, Government General Hospital,Kurnool from January 2021 to October 2022 Bone marrow aspiration was done by
using Salah's bone marrow puncture needle. Smears were made from bone marrow aspirate (BMA) and stained by Leishman
stain and special stains like Perl`s wherever necessary. The smears were assessed for cellularity, differentiation and
maturation of erythroid, myeloid and megakaryocytic lineage, M:E ratio, Plasma cells, Lymphocytes and parasites/ abnormal
cells. In the present study the commonest cause of Pancytopenia was Megaloblastic anemia (70%) follo Results: wed by
Dimorphic anemia (20%). The less common conditions were Multiple Myeloma (6%),Chronic Myeloid Leukemia(2%),Acute
Leukemia(2%). The present study concludes that com Interpretation and Conclusion: plete primary hematological
investigations along with bone marrow aspiration in pancytopenic patients are helpful for understanding disease process and
to diagnose or to the rule out causes of pancytopenia. These are also helpful in planning for further investigations and
management.
“A CO-RELATION OF FIRST TRIMESTER LEVELS OF PAPP-A (PREGNANCY ASSOCIATED PLASMA PROTEIN A) AND PIGF (PLACENTA INDUCED GROWTH FACTOR) WITH CO RELATION OF PREECLAMPSIA AND FETOMATERNAL OUTCOME.”
Authors: Sutariya Helee , D. Nakum Kanaklata
Published: March 2023

Introduction: Preeclampsia is one of the major cause of maternal and fetal mortality. Pathogenesis of
development of preeclampsia is still not clear but one of the cause is considered to be abnormal
placentation. Various markers haven been found to be involved in process of placentation among which PAPP-A and PIGF have
been found to be actively involved. PAPP-A and PIGF levels have not been studied in the Indian population in terms of
preeclampsia prediction at 10-14 weeks of gestation, and we intend to study their levels for early preeclampsia prediction.
Methodology: This observational study was carried out in obstetrics and gynecology OPD , Sir T Hospital , Bhavnagar from
June-2021 to August 2022. Total of 100 antenatal patients attending OPD who were in rst trimester taken after considering
inclusion and exclusion criteria. Investigations for PAPP-A and PIGF were taken and patient followed up for development of
preeclampsia till delivery. Incidence of preeclampsia was found to be 22%. Majority of patients Results: were found in age
group of 26-30 years. More number of patients were multigravida who developed preeclampsia. PAPP-A during rst trimester
were found as 1.06 ± 0.20 MoM in overall patients, while PIGF found as 0.97 ± 0.18 MoM. Moreover, mean PAPP-A and PIGF of
control and case group were found as (1.11 ± 0.22 MoM vs 0.91 ± 0.21 MoM; p<0.0001) and (0.99 ± 0.17 MoM vs 0.88 ± 0.20
MoM; p<0.0001) respectively. 90% of babies delivered full term. In women with preeclampsia 10% patients had preterm
delivery. 50% babies were low birth weight in women who developed preeclampsia. Keepi Conclusion: ng the complications
associated with preeclampsia, measurement of PAPP-A and PIGF levels in rst trimester can be used as marker for prediction of
preeclampsia in later months of pregnancy. Levels if found lower can help in taking regular follow up of patients and early
diagnosis and management can be done. This can help us prevent maternal as well as fetal morbidity and mortality.
NEVUS SEBACEOUS : A CASE REPORT AND REVIEW OF LITERATURE
Authors: S Soundarya , Akhila Vara Madhuri V. , Anandhajhothi Anandhajhothi , Thomas Jayakar
Published: March 2023

Nevus sebaceous (aka. Nevus Sebaceous of Jadassohn or Organoid nevus ) is a hamartomatous disorder
of the skin and is an epidermal appendageal nevus disorder with predominant sebaceous gland
involvement .The Diagnosis of which is mainly based on the clinical presentation ,histopathology and dermoscopy can be useful
when the diagnosis is in doubt .Careful clinical follow up followed by a therapeutic excision might sufce but a prophylactic full
thickness complete excision is recommended as there are rare chances of malignant transformation with chances of recurrence ,
metastasis and fatal outcome .In this article we report a case of nevus sebaceous along with a review of literature
PRELIMINARY INVESTIGATION INTO MECHANICAL PROPERTIES AND MICROSTRUCTURAL BEHAVIOUR OF INCONEL ALLOY UNDER WELDED AND UNWELDED CONDITIONS
Authors: Dewangan Saurabh , Narayanan Sharath , Singh Gill Gurbaaz , Chadha Utkarsh
Published: March 2023

This work focusses on analysing mechanical properties and microscopic assessment into Inconel-718 plates in welded and unwelded conditions. Welding was performed by tungsten inert gas welding technique. Two mechanical tests such as tensile test and hardness were performed on both the types of plates to compare the properties of welded joint and unwelded plate. Although Inconel 718 possesses good weldability, the strength, ductility, and hardness of welded joint were reported lesser than these of Unwelded plate. The microstructural images revealed that metal carbides present in Inconel plate had reduced after welding. The ultimate tensile stress and elongation before breaking of welded joint were 16% and 72% lower than Unwelded plate. The fractography analysis of the ruptured part revealed that Unwelded plate possessed higher ductility than welded plate.
A research study on creation of seed hubs for increasing indigenous production of pulses in India
Authors: Ramakrishna Kommagoni , Reddy T. Prabhakar , Rajashekhar M. , Rajashekhar B. , Shankar Adi , Jahan Afifa , Reddy Jagan Mohan
Published: March 2023

KVK, Palem, Nagarkurnool district Telangana state was allotted with the seed hub project entitled with Creation of seed hubs for increasing indigenous production of pulses in India. With the project buy back policy KVK was procured 284 quintals of Greengram (WGG 42), 571 quintals of Redgram (PRG 176), 234 quintals of Blackgram (PU 31) and 2.2 quintals of Horsegram (CHRG 19) from the farmers and INR 13, 49,989 was earned by the 51 farmers as additional income from seed production. Total 1,091 quintals of pulses seed was procured by KVK, Palem, during 2016 to 2020.  (4years).Seed production was implemented on farmers’ fields across different villages of Nagarkurnool and Jogulamba Gadwal districts based on farmers experience in pulse seed production through bye back agreement. These quality seeds covered through our intervention nearly 7,690 hectares, contributing 16 to 18 per cent of total cropped area under cultivation of pulses in Nagarkurnool district. The total gross amount realized from pulses seed production programme in the four years (2016-17, 2017-18, 2018-19 and 2019-20) was INR 1.24 crores. The net profit to KVK, Palem, is INR 41, 92,086. The profit generated out of seed sale has been utilized by Seed-Hub for development of additional facilities/workforce as needed for scaling quality seed production of pulses.  It is noteworthy that this programme generated employment opportunities for rural youth, farm workers and farm women as seed production is a skill oriented work. Regular and timely management practices reduce additional expenditure while producing seeds, so that no additional labour and special input costs were incurred. Socio-economic status of the farmers has improved due to generation of additional income through seed production as compared to general cultivation.
Growth, yield and economic analysis of eucalypts-barley based agroforestry system in semi-arid region of India
Authors: Kombra Stanley , Ahlawat Karan , Sirohi Chhavi , Dalal V. , Kumar Sanjay , Poonia P. , Kumari S. , Yadav Sneh
Published: March 2023

The present investigation was carried out in the research area of Department of Forestry, CCS Haryana Agricultural University, Hisar during the year 2017-18 to evaluate the effect of 2.8 years old already established eucalypts plantation at 7×3 m on growth, yield attributes and yield of barley. The maximum growth increment in plant height (14.1 m) and diameter at breast height (10.3 cm) of eucalypts was recorded under agroforestry than sole eucalypts (without crop). The maximum plant height (98.5 cm), dry matter accumulation (1098.3 g/m2), tillers/ m2 (360.5), grain yield (3.28 t/ha), straw yield (4.32 t/ha) and biological yield (7.60 t/ha) were observed at harvesting of barley in control (devoid of eucalypts trees) than barley intercropped with eucalypts. However, maximum number of days taken for spike emergence (50 %) (97.4 days) and days to maturity (139.4 days) of barley were recorded under eucalypts plantation. The average per cent reduction of 11.33 % in effective tillers/ m2, 15.15 % in spike length and 16.62 % in number of grains per spike in barley was recorded under eucalypts plantation over control. Maximum net return (Rs. 93347.1 ha-1) was observed under eucalypts + barley cropping system than control. The overall B:C ratio was calculated higher in eucalypts based agroforestry system (1.73) over control (1.15).
Necessity of genetic diversity study and conservation practices in chironji (Buchanania cochinchinensis (Lour.) M.R. Almedia)
Authors: Malakar Ayushman , Sahoo Hareram , Sinha Animesh , Kumar Aditya
Published: March 2023

Chironji (Buchanania cochinchinensis) is an indigenous tree species of Indian subcontinent which belongs to the Anacardiaceae family. It has tremendous potential to uplift the socio-economic status of village dwellers and tribal people. It is used for various purposes including fruits, fuel, fodder and medicines. The species is facing severe ecological and anthropogenic pressures due to indiscriminate harvesting and illicit felling. IUCN has designated Chironji as a vulnerable species indicating that it may be on the verge of extinction if proper conservation measures are not taken very soon. The reports on its conservation and genetic improvement are very less. Hence, it is needed to devise the strategies to conserve its germplasm and genetically improve the species for higher fruit yield. The genetic diversity present in the species is also needed to be studied for effective conservation. Eco-distribution mapping and Molecular characterization using modern tools like molecular markers can give an accurate idea about the genetic diversity in lesser time and will also help in devising the breeding strategies and conservation of its diverse genotype. This review encompasses the researches done on Chironji till date detailing the importance of its genetic diversity and tries to indicate the future conservation and improvement strategies to be taken to fill up the remaining gaps.
Effect of exogenously administered thyroid hormones on gonadotropin, thyrotropin and deiodinases encoding genes in the catfish, Heteropneustes fossilis (Bloch)
Authors: Pant Dinesh Raj , Kumari Pooja
Published: March 2023

Thyroid hormones are known to regulate the basal metabolism rate of an organism. They are also known to regulate the seasonal reproduction of long-day breeding vertebrates in response to thyrotropin induced deiodinase enzymes switching in the brain. The current study attempted to investigate the effect of intraperitoneal administration of thyroxine (T4) and tri-iodothyronine (T3) hormones at various doses on gonadal recrudescence, plasma estradiol-17β and quantitative expression analysis of genes encoding for gonadotropin, thyrotropin, and deiodinases. The estradiol-17β levels were not affected by either thyroid hormone; however, the gonado-somatic index (GSI) and ovarian histology were varying. The gonadotropin releasing hormone 2 (gnrh2) and follicle stimulating hormone-β subunit (fsh-b) gene expressions correspond to the fish GSI and ovarian histology. The gene expressions show that T4 inhibits the expression of thyroid stimulating hormone-β subunit (tsh-b) and type 3 deiodinase (dio3), though it enhances the expression of type 2 deiodinase (dio2). T3, on the other hand, inhibits tsh-b and dio2 expression while increasing dio3 expression. In summary, the T4 appears to regulate gonadal recrudescence in Heteropneustes fossilis in a dose-dependent manner, whereas the T3 appears to have no effect on gonadal activity.
POTENTIAL OF RAINWATER HARVESTING FOR ENHANCED WATER SECURITY IN KAHAWA SUKARI PERI-URBAN ECOSYSTEM IN KIAMBU COUNTY, KENYA
Authors: Fuchaka Waswa , Mwamburi Mcharo , Shitanda Douglas
Published: March 2023

Water is a critical ecosystem service, whose scarcity is increasing in urban and peri-urban areas commensurate with population growth. This paper reports on the potential of roof-based rainwater harvesting as an option in mitigating this challenge and complementing metered water supplies. Roof footprints were mapped and computed using standard GIS procedures. A social survey using questionnaires was used to collect data from homeowners in the estate. The social data were subjected to descriptive statistics to yield general trends on water availability, use, and management. Rainfall data covering the period 2005-2017 was obtained from the Kenyatta University Field Meteorological Station. Results showed that at least 90% of households depend on Nairobi Water and Sewerage Company for water. Despite the prevailing water shortages, about 80% of homes lack complete and functioning rainwater harvesting infrastructure. Potential harvests based on a standard roof area of 350 m2 per residence range from 5250 to 63,350 litres per month, with a mean of 26,000 litres. The two rainy seasons can in particular yield significant quantities of water and greatly enhance water security in the area. Scaling-up of rainwater harvesting can however benefit from appropriate policy incentives such as lowering the cost of plastic tanks to make them more affordable, and including rainwater harvesting infrastructure as a requirement for construction approvals.
ANALYSIS OF THE BALANCE OF PRODUCTION AND CONSUMPTION OF FRUIT AND BERRY PRODUCTS IN UKRAINE
Authors: PRAVDIUK Natalia , PRAVDIUK Maryna
Published: March 2023

In the article was analyzed the current state and trends of development of the production and consumption of fruit and berry products in Ukraine. The article identifies problematic aspects of the activities of business entities in the modern economic realities, outlines possible ways of leveling or minimizing the impact of existing problems, and determines the prospects for the further development of agricultural enterprises and households. It was established that Ukraine has a significant natural resource, material, technical and human potential for increasing the volume of production of fruit and berry products to meet the consumer needs of the population for high-quality products on the domestic and foreign food markets. In particular, the conducted analytical studies indicate an increase in the production of fruit and berry products in general and per person, which is due to an increase in the yield of fruit and berry crops with a significant reduction in the fruit-bearing areas of perennial plantations, an increase in export-import operations. It was determined that the lion’s share in the volume of production of fruit and berry products in Ukraine is provided by the households, which for a long time have made a significant contribution to meeting the consumer needs of the population and remain significant players in the food market. It is substantiated that the further increase in the volume of production of fruit and berry products is connected with the development of small and medium-sized agribusiness, which is flexible enough and able to quickly respond to the challenges of the current situation in Ukraine. In order to ensure competitive advantages, create prerequisites for the further progressive development of the horticulture industry and balance the volumes of production and consumption of fruit and berry products, it is proposed to intensify activities related to the use of resource-saving production technologies, to improve the varietal composition of fruit and berry crops, to create and expand opportunities for the processing, freezing and storage of products in the places of their cultivation, to search for additional sales channels for fruit and berry products for the maximum realization of the export potential of Ukraine.
Monkeypox Outbreak - Case Report
Authors: Reinfeld Howard B
Published: March 2023

A zoonotic disease, monkeypox virus disease, appeared once in the west and central Africa. On July 23, 2022, the WHO designated the current monkeypox epidemic a public health emergency of worldwide concern in the context of the COVID-19 pandemic. The rapidly growing number of confirmed cases may endanger international society. According to current epidemiological statistics, the high frequency of human-to-human transmission might lead to more epidemics, particularly among males who have sex with men. Despite some therapeutic effects of presently used medications in the clinic, the development of antiviral treatments and vaccines against the monkeypox virus is urgent.
Chiari Malformations: A Review of the Current Literature
Authors: Rodríguez Erik Muñoz
Published: March 2023

Chiari malformations (CM) are a group of malformations involving the posterior fossa and rhombencephalic structures that may have other associated intra- or extracranial defects. Initially, the 4 classic varieties were described by the Austrian pathologist Hans Chiari towards the end of the 19th century; years later, the Swiss pathologist Julius Arnold described a case of type II CM with associated myelomeningocele. years later, two of his students used the term "Arnold-Chiari Malformation", this term is often misused for all types. Currently it is estimated that the incidence and prevalence data are underestimated due to the asymptomatic presentation of the pathology in many cases and the limited access to health services of different populations at a global level, for this reason the epidemiological data vary between the literature. The original classification has been modified by contributions from various authors in order to more precisely describe the variety of morphological findings; currently the classification includes CM types 0, I, 1.5, II, III and IV. The symptoms and associated pathological conditions vary for each type and type III and IV are the most severe forms. Diagnosis requires that secondary causes of cerebellar tonsillar ectopy (main finding of CM) be ruled out, along with a physical examination, neurological evaluation, and complementary tests; however, diagnosis requires resonance neuroimaging to demonstrate the findings. The management basically consists of performing a decompression of the posterior fossa and whose main indication is to reduce the symptoms, however, it should be noted that there is no global agreement among specialists on the subject of surgical management, for which each patient must be individualized by your treating physician and the decision made is subject to individual criteria.