bluuebunny/crossref_metadata_2025 huggingface dataset:
Laterite Integrated Persulfate Based Advanced Oxidation and Biological Treatment for Textile Industrial Effluent Remediation: Optimization and Field Application
Authors: Syam Babu Davuluri , Vijay Kunamineni , Shakira Shaik , Mallemkondu Venkatasai Sumasri , Barik Puspita , Kuppam Chandrasekhar , Kommoju Vallayyachari , Mikkili Indira , Mulatu Adamu , Chanikya Pinapala , Raju M. V.
Published: February 2025

This study investigated a combined approach of a persulfate‐based advanced oxidation process (AOP) followed by biological treatment of a textile industrial effluent. The effluent from the textile industry is primarily composed of various dyes in varying concentrations, resulting in high chemical oxygen demand (COD) and biological oxygen demand (BOD). The model pollutant rhodamine B (RhB) was used in the optimization studies. During the persulfate oxidation process (PSO), persulfate activation is required to generate sulfate radicals (SO4•−). Raw laterite soil was used as a catalyst for the treatment of RhB in batch studies, and it was able to reduce the dye concentration by about 20% in 60 min of operation, with initial RhB concentrations of 150 mg L−1 and persulfate concentrations of 200 mg L−1. Furthermore, alkali‐treated laterite soil (ATLS) was used as a catalyst, achieving 57%–60% removal in 60 min at pH 3 and complete removal after 72 h of biological treatment. Furthermore, the optimized conditions were tested on real field waters to determine efficiency, and it was observed that the PSO removed approximately 45% of COD, with further biological treatment for 72 h increasing the removal efficiency to 64%. All other parameters of water quality were reduced by more than 60%.
Adipose‐Derived Stem Cell Exosomes Promote Scar‐Free Healing of Diabetic Wounds via miR‐204‐5p/TGF‐β1/Smad Pathway
Authors: Song Peijun , Liang Qiu , Ge Xiuyu , Zhou Danlian , Yuan Mei , Chu Weiwei , Xu Jing
Published: February 2025

Numerous researches have demonstrated the therapeutic potential of adipose‐derived stem cell exosomes (ADSC‐Exos) in promoting wound healing. In this study, we aimed to investigate the impact of ADSC‐Exos on diabetic wound fibroblasts and elucidate its possible mechanisms. CCK‐8, Edu, cell scratch, and Transwell tests were used to evaluate the function of ADSC‐Exos on rat skin fibroblasts (RSFs) in high‐glucose (HG) medium. The targeting effect of ADSC‐Exo‐derived microRNA (miRNA) and TGF‐β1 was assessed using bioinformatic analysis and then confirmed with western blot and dual luciferase reporter assays. ADSC‐Exos, miR‐204‐5p mimic, and anti‐miR‐204‐5p mimic were used to stimulate RSFs, and the levels of TGF‐β1/Smad pathway were analyzed by western blot. In vivo, digital photo and tissue section staining were used to evaluate the therapeutic effect of ADSC‐Exos on diabetic wounds. The data showed that ADSC‐Exos enhance the proliferation and migration of fibroblasts under HG conditions, reduce excessive myofibroblast differentiation and collagen deposition, and promote scarless healing of diabetic wounds. Additionally, miR‐204‐5p in ADSC‐Exos targets TGF‐β1 to inhibit p‐Smad2/3, Col I, and alpha‐smooth muscle actin (α‐SMA), thereby reducing fibrosis. These findings suggest that ADSC‐Exos have potential prospects for promoting diabetic wound healing.
Table S3 from PARP Inhibitors Differentially Regulate Immune Responses in Distinct Genetic Backgrounds of High-Grade Serous Tubo-Ovarian Carcinoma
Authors: Doro Pereira Luiza , Wielgos-Bonvallet Monica , Misirlioglu Selim , Khodadai-Jamayran Alireza , Jelinic Petar , Levine Douglas A.
Published: February 2025

Supplementary Table 3 shows enriched gene sets upregulated in OVCAR3 cells treated with veliparib .
Figure S4 from PARP Inhibitors Differentially Regulate Immune Responses in Distinct Genetic Backgrounds of High-Grade Serous Tubo-Ovarian Carcinoma
Authors: Doro Pereira Luiza , Wielgos-Bonvallet Monica , Misirlioglu Selim , Khodadai-Jamayran Alireza , Jelinic Petar , Levine Douglas A.
Published: February 2025

Supplementary Figure 4 shows IP-10 (CXCL10) expression levels in drug-treated cell lines.
Figure S1 from PARP Inhibitors Differentially Regulate Immune Responses in Distinct Genetic Backgrounds of High-Grade Serous Tubo-Ovarian Carcinoma
Authors: Doro Pereira Luiza , Wielgos-Bonvallet Monica , Misirlioglu Selim , Khodadai-Jamayran Alireza , Jelinic Petar , Levine Douglas A.
Published: February 2025

Supplementary Figure 1 shows clustering of drug-treated cells compared to controls.
Figure 5 from PARP Inhibitors Differentially Regulate Immune Responses in Distinct Genetic Backgrounds of High-Grade Serous Tubo-Ovarian Carcinoma
Authors: Doro Pereira Luiza , Wielgos-Bonvallet Monica , Misirlioglu Selim , Khodadai-Jamayran Alireza , Jelinic Petar , Levine Douglas A.
Published: February 2025

PARPi–induced CXCL10 gene expression levels are not affected by STING knockdown in a cGAS-defective cell line. A, The expression levels of STING and cGAS were measured by western blot analysis 48 hours after DMSO treatment. ERK2 was used as a loading control. Results shown are from one of two independent experiments. B–E, OVCAR3 and CAOV3 were transfected with control or STING siRNA for 24 hours. Cells were re-plated the next day and treated 48 hours after transfection with DMSO, 10 μmol/L veliparib, or 2 μmol/L talazoparib. Total RNA was extracted from cell pellets that were collected 48 hours after drug treatment, and then 1 μg of RNA was reverse transcribed to cDNA. Quantitative real-time RT-PCR was utilized to measure the gene expression levels of TMEM-173 (STING), CXCL10, and GAPDH. T tests were performed between the control siRNA DMSO-treated group and the five other conditions. A t test was also performed between the control siRNA veliparib- vs. STING siRNA veliparib-treated groups and the control siRNA talazoparib- vs. STING siRNA talazoparib-treated groups. *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001; ns, not statistically significant.
Figure 3 from PARP Inhibitors Differentially Regulate Immune Responses in Distinct Genetic Backgrounds of High-Grade Serous Tubo-Ovarian Carcinoma
Authors: Doro Pereira Luiza , Wielgos-Bonvallet Monica , Misirlioglu Selim , Khodadai-Jamayran Alireza , Jelinic Petar , Levine Douglas A.
Published: February 2025

IL-8 (CXCL8) is exclusively secreted in BRCA1 methylated or mutated HGSC cells after olaparib treatment but is secreted in all HRD HGSC cells after talazoparib treatment. A, OVCAR3, (B) OVCAR8, and (C) COV362 cells were treated with DMSO, 10 μmol/L veliparib, 10 μmol/L olaparib, or 2 μmol/L talazoparib for 48 hours. The supernatants were then collected, and IL-8 protein expression was analyzed by an ELISA assay. A four-parameter logistic curve fit was used to analyze these results. T tests were performed between DMSO- and the individual PARPi–treated groups. **, P < 0.01; ***, P < 0.001; ****, P < 0.0001; ns, not statistically significant.
Figure 2 from PARP Inhibitors Differentially Regulate Immune Responses in Distinct Genetic Backgrounds of High-Grade Serous Tubo-Ovarian Carcinoma
Authors: Doro Pereira Luiza , Wielgos-Bonvallet Monica , Misirlioglu Selim , Khodadai-Jamayran Alireza , Jelinic Petar , Levine Douglas A.
Published: February 2025

Expression levels of pro-inflammatory genes and proteins are increased by talazoparib treatment in two HGSC cell line models. Total RNAs were isolated from (A) OVCAR3 and (B) CAOV3 cells treated with DMSO, 10 μmol/L veliparib, 100 nmol/L talazoparib, or 2 μmol/L talazoparib for 48 hours. Two micrograms of isolated RNA was reverse transcribed to cDNA and then analyzed by qRT-PCR for CXCL8, IL-6, and TNF expression. GAPDH was used as a housekeeping gene. The supernatants from (C) OVCAR3 and (D) CAOV3 cells were collected 48 hours after the addition of DMSO, 10 μmol/L veliparib, 100 nmol/L talazoparib, or 2 μmol/L talazoparib. IL-8 protein expression was then analyzed by an ELISA assay. A four-parameter logistic curve fit was used to analyze these results. Means are representative of three independent experiments performed in triplicate in all qRT-PCR and ELISA experiments. T tests were performed between DMSO- and the individual PARPi–treated groups. *, P < 0.05; **, P < 0.01; ***, P < 0.001; ns, not statistically significant.
The Potency of Adipose-Derived Mesenchymal Stem Cells to Increase Ovarian Function in Primary Ovarian Insufficiency: A Systematic Review of in vivo Studies
Authors: Adventa Yohanes Iddo , Rachmawatia Anita , Tjahyadia Dian
Published: February 2025

Introduction
Primary ovarian insufficiency (POI) that caused infertility could decrease the quality of life in women. Therefore, an effective treatment is needed. Adipose-derived stem cells (ADSCs) have been reported to have therapeutic benefits in POI. This review aims to evaluate the therapeutic effect of ADSCs in POI.
Methods
Literatures were searched according to PRISMA 2020 guidelines in the following databases: PubMed, ProQuest, Wiley, Emerald, and JSTOR (until July 10th, 2024). The study inclusion criteria are original articles, in vivo study with adipose-derived stem cells therapy towards POI with ovarian function as the outcome. SYRCLE’s risk of bias tool was used to evaluate the quality of the studies.
Results
We retrieved 9 from 292 articles published in English between 2013 and 2024. Animals used in this study were mice (n=5) and rats (n=4). ADSCs were administered either systematically or directly by injection into the ovaries. Decreased apoptosis, increased follicle survival, and hormone levels were observed. These showed that ADSCs implantation could improve ovarian function in rats and mice. Overall, ADSCs in POI showed satisfactory results.
Conclusion
ADSCs showed benefits in increasing ovarian function in POI. Further studies, especially human studies are needed to evaluate the efficacy and side effects of the ADSCs treatment before reaching general conclusions.
Behavior Risk Factors for Non-Communicable Diseases and Caries in Adolescents: A Population Study
Authors: Monteiro Edna Luisa Oliveira , Ladeira Lorena Lúcia Costa , Costa Cayara Mattos , Monteiro Mylla Cristie Campelo , Rebelo Maria Augusta Bessa , Alves Claudia Maria Coelho , Thomaz Erika Barbara Abreu Fonseca , Ribeiro Cecilia Claudia Costa
Published: February 2025

Introduction: Caries is the most widespread non-communicable disease (NCD) globally and can predict fatality NCDs in the future, such as diabetes and cardiovascular diseases. Therefore, we hypothesized that the behavioral risk factors for those NCDs may be present in adolescents with caries. Objective: To analyze the association of unhealthy diet, tabagism, and alcohol with caries in adolescents. Methods: This population-based study with a cross-sectional design used data from 2515 adolescents aged 18-19 yo, born in São Luís-MA, Brazil, and part of the RPS Cohort Consortium. The exposures were the latent variables of the Unhealthy Diet Pattern (sugars, fast foods, and salty snacks) and Addictive Behaviors (tabagism and risk of alcohol dependence). The outcome was the number of decayed teeth. The model adjustment considered the Socioeconomic Status (head of household education, adolescent education, economic class, and monthly family income) as a distal determinant and the oral biofilm as a mediator between the exposures and the outcome, analyzed by Structural Equation Modeling (SEM), using the Mplus 8.0 software. Results: Unhealthy Diet Pattern was associated with a higher number of decayed teeth directly (SC=0.092, p≤0.001) and indirectly via dental biofilm (SC=0.020, p≤0.001). Addictive Behaviors were associated with a higher number of decayed teeth indirectly via dental biofilm (SC=0.019, p=0.013). The Unhealthy Diet Pattern and Addictive Behaviors were associated with each other (CP=0,199; p<0,001). Conclusion: Besides sugars, other behavioral risk factors for NCDs underlie caries, emphasizing the importance of comprehensive adolescent health care.
Comparação da assimetria de força manual entre praticantes e não praticantes de musculação
Authors: Santos Thamires Gabriela Silva , Barbosa Beatriz Abelha Coelho , Perondi Darlan , Apolinário-Souza Tércio , Fernandes Lidiane Aparecida
Published: February 2025

A assimetria lateral é um dos campos de estudo da lateralidade, que corresponde com a superioridade no desempenho de atividades com um lado do corpo, a assimetria lateral pode ser dividida em assimetria de preferência e assimetria de desempenho. Objetivo: Comparar a assimetria de força de pressão manual entre praticantes e não praticantes de musculação. Método: Este estudo avaliou 50 indivíduos, de ambos os sexos e com faixa etária entre 18 e 35 anos. Os participantes foram divididos em 2 grupos (praticantes e não praticantes de musculação). Para determinar a lateralidade dos participantes foi utilizado o Inventário de Dominância Lateral de Edimburgo. Foi utilizado um dinamômetro analógico manual, para a mensuração da força de preensão manual dos sujeitos. A tarefa consistiu em realizar o movimento de força de preensão manual com o aparelho dinamômetro seguindo as recomendações da American Society of Hand Therapists (ASHT). Resultados: Foram encontradas diferenças entre os grupos de praticantes (GP) e não praticantes de musculação (GNP) no desempenho da mão esquerda (p<0,02). Na comparação entre mãos do mesmo grupo, no GP não foram identificadas diferenças estatísticas significativas (p= 1,000), já no GNP foi encontrada diferença estatística significativa (p<0,001). Conclusão: Conforme os resultados encontrados no presente estudo, pode-se especular que a prática de musculação pode provocar redução na diferença de desempenho na preensão manual entre os membros superiores, dessa forma diminuindo as assimetrias entre membro direito e membro esquerdo.
A intervenção do Fisiatra na terapêutica das incapacidades esfincterianas
Authors: Silva Filho Francivaldo Araújo da , Pinto Júnior Alexandre Otílio , Chiappetta Lorella Marianne , Sarmento Viviane Porangaba , Lima Delane Henrique de Araújo Ramires
Published: February 2025

A incontinência visceral pode ser dividida em urinária (IU) e/ou fecal definidas pela perda involuntária de urina e de fezes ou gases, respectivamente, em locais inadequados, podendo ocorrer em qualquer faixa etária, após a aquisição do controle esfincteriano. Tal temática, apesar de trazer sérias complicações à qualidade de vida do indivíduo, infelizmente, ainda recebe pouca atenção na assistência, nas publicações científicas e, muitas vezes, nas sociedades médicas. Dessa forma, a real prevalência das incontinências é subestimada. Nos dias atuais, a baixa investigação dessas perdas, pelos profissionais de saúde, e a quantidade limitada de queixas pelos indivíduos acometidos, dificultam as ações voltadas para sua prevenção. No Brasil, a prevalência é mais alta em mulheres do que em homens nas idades mais jovens, principalmente por causas anatômicas, e estima-se que entre 11 e 23% das mulheres sejam incontinentes. Entretanto, o risco de sofrer perdas urinárias aumenta com a idade, e a diferença na prevalência entre homens e mulheres diminui.
Controle postural dinâmico de crianças com transtorno do espectro autista e relação com a Classificação Internacional de Funcionalidade, Incapacidade e Saúde: revisão sistemática e análise de qualidade
Authors: Viana Mylena Oliveira , Fiebrantz Ana Luiza dos Santos , Gardinal Marina , Rago Silvia Letícia Pavão
Published: February 2025

A prática clínica em disfunções do neurodesenvolvimento, como o Transtorno do Espectro Autista (TEA), demanda uma abordagem baseada em evidências científicas, sendo o controle postural (CP) uma área crucial. Este estudo visa revisar sistematicamente a literatura sobre o CP dinâmico em crianças com TEA, explorando sua relação com os domínios de saúde da CIF e avaliando a qualidade metodológica desses estudos.
Desafio diagnóstico da plexopatia braquial idiopática: um relato de caso
Authors: Ferreira Luciana Borges , Nóbrega Vanessa Cardoso Barrientos , Farina Thiago Calcagnotto
Published: February 2025

A Plexopatia Braquial Idiopática, também conhecida como Síndrome de Personage-Turner, manifesta-se como dor aguda e intensa no ombro e na cintura escapular, seguida de alívio álgico e surgimento de paresia e atrofia da musculatura, envolvendo, principalmente, os Nervos Torácico Longo, Supraescapular e Interósseo Anterior. A incidência é de dois a três indivíduos a cada 100.000 habitantes.3 Embora a etiologia ainda seja desconhecida, sabe-se que existem fatores infecciosos e autoimunes envolvidos.
Doença de Pompe, desafio no atendimento do fisiatra: 2 relatos de caso
Authors: Castro Grace Vanessa Aguas , Magalhães Bruno de Souza Rios
Published: February 2025

A doença de Pompe (DP), também conhecida como glicogenose tipo II ou deficiência de maltase ácida é uma doença genética rara, subdiagnosticada de acometimento neuromuscular progressivo que leva à falha terapêutica antes da confirmação diagnóstica, frequentemente fatal nas formas mais graves. Pode ser classificada em grupos A, B, C e D, de acordo com a idade do início dos sintomas, envolvimento cardíaco e velocidade de progressão da doença.
Eletromassagem no tratamento das disfunções neuromusculoesqueléticas: uma revisão integrativa de literatura
Authors: Viana Mylena Oliveira , Korelo Raciele Ivandra Guarda
Published: February 2025

Terapias manuais e correntes elétricas são amplamente usadas nas condições neuromusculares, com potencial terapêutico positivo, baixo custo e poucos efeitos adversos. A eletromassagem consiste na aplicação de correntes terapêuticas associados a eletrodos em movimentos de leve a média pressão, prometendo benefícios sinérgicos na melhora do processo inflamatório e funcionalidade. Contudo, ainda não estão esclarecidos seus efeitos.
Impacto da inserção de medicina integrativa em centro de reabilitação física integrado, no cuidado de pacientes neurológicos, cuidadores e funcionários: dados preliminares
Authors: Marques Caio Vinicius Silva , Padula Natalia , Rodrigues Ana Claudia , Nunes Thalyta Souza de Goes
Published: February 2025

A Medicina Integrativa é uma prática que visa o cuidado integral a partir da visão holística, onde o paciente recebe o cuidado amplo nos aspectos mentais, emocionais, físicos e espirituais que englobam a saúde mental. Nesse sentido, é chamada de terapia complementar, já que complementa as demais terapêuticas que o indivíduo irá realizar durante a vida.
Lesões neurológicas e tempo de internação em hospital referência em reabilitação no Distrito Federal
Authors: Fraianelli Vanessa Fenili , Martins Alliny do Nascimento , Sayago Mariana , Barros Débora Santos Lula , Silva Emília Vitória da
Published: February 2025

Mundialmente, dados da Organização Mundial da Saúde (OMS) estimam que uma em cada três pessoas hoje vive com uma condição de saúde que se beneficiaria com a reabilitação. No Brasil, o Sistema Único de Saúde (SUS) fornece diretrizes para estruturar e planejar serviços de reabilitação, como os Centros Especializados de Reabilitação, que oferecem tratamentos especializados, mostrando um esforço conjunto para atender à crescente demanda por este serviço.
Reabilitação e qualidade de vida em amputação unilateral de membro inferior
Authors: Hociko Ana Paula , Gomes Caio Ribeiro Azevedo , Matuti Gabriela da Silva , Wang Rafael Chao Ming , Kuwae Leticia Miti
Published: February 2025

Uma amputação gera deficiência permanente e drásticas mudanças de vida, acarretando em limitações físicas, dificuldade para participar de eventos sociais e retornar ao mercado de trabalho, além de impactar a qualidade de vida. O processo de reabilitação é fundamental para promover a melhora da funcionalidade e da qualidade de vida do paciente amputado.
Reforço a orientação familiar - aceitação e aquisição da cadeira de rodas após a prescrição
Authors: Souza Jousy Pimentel de , Santos Almira Alves dos , Sarmento Viviane Porangaba , Chiappetta Lorella Marianne , Silva Júnior Francivaldo Araújo da
Published: February 2025

Dentro das intervenções terapêuticas na reabilitação física, a orientação terapêutica é recorrente sendo em sua maioria verbais e/ou relatórios sobre a condição do paciente ao longo do tratamento. Na prática clínica observa-se dificuldade da família em aderir a recomendação e prescrição de cadeira de rodas para crianças em idades mais tenras devido o receio de um prognóstico negativo para deambulação.
Risco cardiovascular em pacientes com osteoartrite de joelho
Authors: Imamura Marta , Santos Artur Cesar Aquino dos , Parise Barbara Khonangz , Uchiyama Sabrina Saemy Tomé , Battistella Linamara Rizzo
Published: February 2025

A relação entre a osteoartrite (OA) e as doenças cardiovasculares (DCV) tem sido objeto de crescente interesse científico. Enquanto a OA é tradicionalmente considerada uma condição localizada nas articulações, evidências emergentes sugerem uma conexão entre essa doença crônica e a saúde cardiovascular.
Prognostic Relevance of Type 4a Myocardial Infarction and Periprocedural Myocardial Injury in Patients With Non–ST-Segment–Elevation Myocardial Infarction
Authors: Armillotta Matteo , Bergamaschi Luca , Paolisso Pasquale , Belmonte Marta , Angeli Francesco , Sansonetti Angelo , Stefanizzi Andrea , Bertolini Davide , Bodega Francesca , Amicone Sara , Canton Lisa , Fedele Damiano , Suma Nicole , Impellizzeri Andrea , Tattilo Francesco Pio , Cavallo Daniele , Di Iuorio Ornella , Ryabenko Khrystyna , Rinaldi Andrea , Ghetti Gabriele , Saia Francesco , Marrozzini Cinzia , Casella Gianni , Rucci Paola , Foà Alberto , Pizzi Carmine
Published: February 2025

BACKGROUND:

Periprocedural myocardial injury (PMI) with or without type 4a myocardial infarction (MI) might occur in patients with non–ST-segment–elevation MI (NSTEMI) after percutaneous coronary intervention (PCI). This study investigated the incidence and prognostic relevance of these events, according to current definitions, in patients with NSTEMI undergoing PCI. The best cardiac troponin I (cTnI) threshold of PMI for prognostic stratification is also suggested.

METHODS:

Consecutive patients with NSTEMI from January 2017 to April 2022 undergoing PCI with stable or falling pre-PCI cTnI levels were enrolled. According to the Fourth Universal Definition of Myocardial Infarction, the study population was stratified into those experiencing (1) PMI with type 4a MI, (2) PMI without type 4a MI, or (3) no PMI. Post-PCI cTnI increase >20% with an absolute postprocedural value of ≥5 times the 99th percentile upper reference limit within 48 hours after PCI was used to define PMI. The primary end point was 1-year all-cause mortality, and the secondary end point consisted of major adverse cardiovascular events at 1 year, including all-cause mortality, nonfatal reinfarction, urgent revascularization, nonfatal ischemic stroke, and hospitalization for heart failure. Internal validation was performed in patients enrolled between May 2022 and April 2023.

RESULTS:

Among 1412 patients with NSTEMI undergoing PCI with stable or falling cTnI levels at baseline, 240 (17%) experienced PMI with type 4a MI, 288 (20.4%) experienced PMI without type 4a MI, and 884 (62.6%) experienced no PMI. PMI was associated with an increased risk of adverse clinical outcomes, with patients with type 4a MI demonstrating the highest rates of 1-year all-cause mortality and major adverse cardiovascular events. A post-PCI ΔcTnI >20% but ≤40% showed similar outcomes to patients without PMI, whereas >40% was identified as the optimal threshold for prognostically relevant PMI, confirmed in an internal validation cohort of 305 patients.

CONCLUSIONS:

Periprocedural ischemic events were frequent in patients with NSTEMI undergoing PCI with prognostic implications. A post-PCI ΔcTnI >40%, combined with an absolute postprocedural value of ≥5 times the 99th percentile upper reference limit, was identified as the optimal threshold for diagnosing prognostically relevant PMI. Recognizing these events may improve risk stratification and management of patients with NSTEMI.
Clinical Characteristics and Outcome of Patients With Myocardial Infarction With Nonobstructive Coronary Arteries in Japan: Insights From the Miyagi Acute Myocardial Infarction Registry Study
Authors: Hao Kiyotaka , Takahashi Jun , Sato Koichi , Fukui Kento , Shindo Tomohiko , Oyama Kazuma , Nishimiya Kensuke , Godo Shigeo , Shiroto Takashi , Shimokawa Hiroaki , Yasuda Satoshi
Published: February 2025

Background

Clinical characteristics and outcomes of patients with myocardial infarction (MI) with nonobstructive coronary arteries (MINOCA) are not fully understood, particularly in Japan.

Methods and Results

We enrolled a total of 8881 patients with acute MI from the Miyagi Acute Myocardial Infarction Registry Study (2012–2020), with a median age of 69 years. Among them, 239 patients (2.7%) were diagnosed with MINOCA. Compared with those with MI with obstructive coronary artery disease (MI‐CAD), patients with MINOCA were more often women, had a higher incidence of non–ST‐segment–elevation MI and a lower prevalence of dyslipidemia. Compared with patients with MI‐CAD, patients with MINOCA in all age groups (<59, 60–69, 70–79, >80 years of age) had a higher incidence of non–ST‐segment–elevation MI. Additionally, those ≤59 years of age were more often women and had a lower prevalence of diabetes and dyslipidemia. In‐hospital mortality increased with age in patients with MI‐CAD (3.9% for <59 years of age, 5.6% for 60–69 years of age, 8.3% for 70–79 years of age, and 15.2% for >80 years of age;
P
<0.01), but not in patients with MINOCA (4.5%, 7.4%, 6.0%, and 9.6%, respectively;
P
=0.36). Compared with patients with MI‐CAD, patients with MINOCA had lower in‐hospital mortality for Killip class IV (40.7% versus 20.0%; adjusted odds ratio [OR], 0.31 [95% CI, 0.10–0.94];
P
=0.04) and renal dysfunction (20.0% versus 7.1%; adjusted OR, 0.29 [95% CI, 0.09–0.96];
P
=0.04).

Conclusions

Patients with MINOCA exhibit distinct clinical characteristics and outcomes compared with those with MI‐CAD, particularly in terms of age, sex, prevalence of comorbidities, and in‐hospital mortality. These findings underscore the importance of tailored clinical approaches for patients with MINOCA.
The genus Sehnemobryum (Bryophyta, Orthotrichaceae) in Argentina
Authors: ALVAREZ DENISE J. , ACEÑOLAZA PABLO G. , SUÁREZ GUILLERMO M.
Published: February 2025

This study reports the presence of the genus Sehnemobryum in Argentina for the first time, based on the collection of S. paraguense. A detailed morphological description is provided, along with illustrations, photographs, and a distribution map.
Gastrodia exianlingensis (Gastrodieae, Epidendroideae), a new species of Orchidaceae from Hainan, China
Authors: HUANG MING-ZHONG , WEI CHUNYI , LI RUYI , TU XIONGDE , ZHAO XUEWEI , LAN SIREN , LIU ZHONG-JIAN
Published: February 2025

N/A
Three Novel Species of Earthworms of Genus Metaphire Sims and Easton, 1972 from Manipur, India
Authors: TIWARI NALINI , SHILPI KAUSHIK , JAMES SAMUEL W. , GUPTA NEELIMA , YADAV SHWETA
Published: February 2025

The systematics of pheretimoids have been hindered by limited diagnostic traits and extensive homoplasy. This study utilized an integrative taxonomic approach, combining morpho-anatomical traits and mitochondrial COI data, to delineate species and clarify phylogenetic relationships among Indian pheretimoids. Three new species of Metaphire (Megascolecidae) were identified: Metaphire manipurensis Tiwari & Yadav sp. nov., belongs to M. houlleti group with three pairs of spermathecal pores (6/7–8/9) and no post-clitellar markings; Metaphire thabiensis Tiwari & Yadav sp. nov. classified within the M. javanica group, with two pairs of spermathecal pores (7/8–8/9) and copulatory pouches lacking stalked glands and Metaphire churachandpurensis Tiwari & Yadav sp. nov., which lacks spermathecal pores but has stalked genital marking glands. Furthermore, phylogenetic analysis of COI data confirmed species placements with strong statistical support and validated species delineation through congruent OTUs. These findings advance phylogenetics and evolutionary trajectory of the group, though expanded COI datasets are needed for broader insights.
Clarification of the controversy around the problematic species “Eophila gestroi” (Cognetti, 1905) in the Balkan
Authors: POPOVIĆ FILIP J. , TRAKIĆ TANJA B. , SEKULIĆ JOVANA M. , DOMÍNGUEZ JORGE , MARCHÁN DANIEL F.
Published: February 2025

The taxonomy and phylogeny of the Southern Alpine species Eophila gestroi (Cognetti, 1905) can be confusing. The main reason for this is the morphological similarity of this species with the Vardar endemic species Cernosvitovia strumicae (Šapkarev, 1973). The confirmation of the identification of our findings based on morphological characters, previous molecular phylogenetic analyses, and biogeographical analysis revealed the misidentification of C. strumicae in earlier studies. Identifying this species is essential in clarifying earthworms’ confusing taxonomic and phylogenetic position on the Balkan Peninsula.
Morphological variability, distribution and taxonomic relationships of Dendrobaena illyrica (Cognetti, 1906) (Lumbricidae)
Authors: POPOVIĆ FILIP J. , SEKULIĆ JOVANA M. , TRAKIĆ TANJA B.
Published: February 2025

This paper provides clear and definitive answers to the confusion caused by parthenogenetic forms in the delimitation of species in the earthworm taxonomy of the Balkan Peninsula. Dendrobaena illyrica (Cognetti, 1906) is a species group with high morphological variability. Its varieties have been described several times under specific names, and erroneous identifications still need to be corrected. Dendrobaena illyrica has been considered a parthenogenetic species. The taxonomic relationships between D. illyrica and the little-known Balkan endemic species Dendrobaena serbica Karaman, 1973 have been a long-standing puzzle. The taxonomic status of D. serbica was clarified by comparing specimens from our collections and literature data, to determine the intraspecific variations of morphological characters. Our specimen’s research has significantly corrected previous misconceptions, indicating that D. serbica shows biparental reproduction with phoral insemination. Considering the morphological and biogeographic differences of the species mentioned, we propose that D. serbica is not a parthenogenetic form of D. illyrica.
A new species of Nitokra Boeck, 1865 (Copepoda: Harpacticoida: Ameiridae) from a hyporheic zone in central Vietnam
Authors: TRAN NGOC-SON , TRINH-DANG MAU , NGUYEN THI TUONG VI , BRANCELJ ANTON
Published: February 2025

A new species of harpacticoid copepod, Nitokra quangnamensis sp. nov. was collected from a hyporheic zone of a river in the central part of Vietnam. It is the second member of the genus described from Vietnam. It belongs to the group III (Gómez et al. 2012), where members have a seta on inner margin of P1 Exp-2 and five setae/spines on P1 Exp-3. The group is also characterized by the number of elements (spines/setae) as: P2–P4 Enp-3 with 4,5,5 elements, P2–P4 Exp-3 with 7,7,7 elements and P2–P4 Enp-1 with 1,1,1 seta on inner margin. The most closely-related species, N. laingensis Fiers, 1986, differs from the new species in: i) N. quangnamensis sp. nov. has seven setae in female P5 Exp, but five setae in N. laingensis; ii) distal segment of a mandibular palp in the new species with six elements, vs. five in N. laingensis; iii) male anal operculum of the new species with six spines, vs. four in N. laingensis.
Two new species of the South African genus Stenomastigus Leleup (Coleoptera, Staphylinidae, Scydmaeninae)
Authors: JAŁOSZYŃSKI PAWEŁ
Published: February 2025

Stenomastigus Leleup currently includes seventeen species and six subspecies, all endemic to South Africa. Two new species are described: S. mpumalanganus sp. nov., and S. bulirschi sp. nov., both based on specimens collected in Mpumalanga province. A preliminary identification key to species and subspecies of Stenomastigus is given.
Improving the employment in less-developed areas through low-carbon city pilot policy: A study on old revolutionary areas in China
Authors: Wang Zhonghua , Gong Zeyi , Zhou Fengxiu
Published: February 2025

Objectives

Understanding approaches to promoting green development as well as to increasing employment in old revolutionary areas from the perspective of the “dual carbon” goals is important and, hence, needs to be studied.

Methods

Using city and enterprise panel data from 2007 to 2019, this study used a differential model to assess the impact of China's low-carbon city pilot policies on employment in old revolutionary base areas.

Results

The results showed that the low-carbon city pilot policies could significantly reduce the carbon emissions of old revolutionary base areas as well as significantly promote an improvement in employment levels. Specifically, low-carbon policies could promote the green technological innovation of enterprises and optimize the industrial structure through both output effects and factor-substitution effects to create more jobs. In addition, the impact of low-carbon city pilot policies on employment in different industries and factor intensity was heterogeneous, and the employment promotion effect was more significant in low-energy industries and non-labor-intensive enterprises.

Conclusions

The research results can enrich the theoretical basis of regional development planning in China, and provide important references that can be used to both stabilize the employment of residents and promote high-quality development in underdeveloped areas.
Ileal bezoar secondary to ileal duplication – a case report
Authors: Rahul Sandip Kumar , Keshri Rupesh , Chaubey Digamber
Published: February 2025

Ileal bezoars usually occur secondary to gastric bezoars, gastric or bowel surgery, or lumen-narrowing lesions of the ileum. Primary ileal bezoars, being rare, are diagnosed only after excluding secondary causes. Ileal duplication associated with bezoar has seldom been reported.
Planning for end of life in the past and present: historical, legal and clinical perspectives on ReSPECT
Authors: van Oppen James David , Gunn Sarah , Coats Timothy John , Papadopoulou Nataly , Senkova Michaela , Tarlow Sarah , Wicks Elizabeth
Published: February 2025

The ReSPECT (‘Recommended Summary Plan for Emergency Care and Treatment’) process was developed in the UK to guide and document conversations and decision-making with patients and their relatives around intervention during critical deterioration. This includes advising whether resuscitation should be attempted when a person dies. Current medical preparation for death is qualitatively different to social behaviours by people in the past and presents some controversies when considering the legal status of death-related decisions. In this article, we discuss our interdisciplinary perspectives as archaeological, historical, legal, medical and clinical psychologist academics following a historico-medico-legal appraisal of the ReSPECT process as situated in the current UK legal and cultural landscape. We review controversies and conundrums, and contextualise and contrast the current position to preparing for death and dying in the past.
Antithrombotic therapies for patients with acute iliofemoral deep vein thrombosis following endovenous recanalization: A single-center study and literature review
Authors: Skeik Nedaa , Li Rina , Cravero Ellen , Engstrom Bjorn , Manunga Jesse
Published: February 2025

Objectives

There is no consensus regarding the optimal antithrombotic therapy following endovenous recanalization. We aim to assess the effectiveness of anticoagulant, antiplatelet, or combination therapy to provide evidence-based recommendations for antithrombotic therapy following interventional procedures.

Methods

An Institutional Review Board approved, retrospective study of patients presented to our facility with iliofemoral venous thrombosis requiring thrombolysis and/or thrombectomy with or without venous angioplasty/stenting between January 1, 2010 and April 1, 2023. Incidence of vein or stent patency, thrombosis, and bleeding were considered primary endpoints and were compared between patients on anticoagulant, antiplatelet, or combination therapies at each post-interventional surveillance, up to five visits.

Results

The cohort yielded 128 patients, including 116 adults and 12 minors. We identified a notable trend in the post-recanalization medical routines of patients: those initially prescribed combination therapy post-procedure eventually transitioned to either exclusive anticoagulant or antiplatelet therapy. The initial combination antithrombotic therapy was associated with trends towards higher vein patency (59% vs 47% with anticoagulant vs 25% antiplatelet, p = .3), less recurrent vein and stent thrombosis (46% vs 54% with anticoagulants vs 100% antiplatelet, p = .10), and overall low major bleeding complications (3.2% vs 6.8% anticoagulant, p = .5) at first follow-up compared to those on anticoagulant or antiplatelet regimens alone.

Conclusion

Although the optimal post-interventional antithrombotic therapy remains uncertain, combination therapy was associated with trends towards higher vein patency and lower recurrent thrombosis, with low overall major bleeding complications at the first follow-up visit following interventions. Future studies encompassing larger and more diverse populations are essential to corroborate the findings presented in this report and offer valuable insights for optimizing the management of patients with this condition.
The Effect of Patient Decision Aid Attributes on Patient Outcomes: A Network Meta-Analysis of a Systematic Review
Authors: Stacey Dawn , Carley Meg , Gunderson Janet , Hsieh Shu-Ching , Kelly Shannon E. , Lewis Krystina B. , Smith Maureen , Volk Robert J. , Wells George
Published: February 2025

Background

Patient decision aids (PtDAs) are effective interventions to help people participate in health care decisions. Although there are quality standards, PtDAs are complex interventions with variability in their attributes.

Purpose

To determine and compare the effects of PtDA attributes (e.g., content elements, delivery timing, development) on primary outcomes for adults facing health care decisions.

Data Sources

A systematic review of randomized controlled trials (RCTs) comparing PtDAs to usual care.

Study Selection

Eligible RCTs measured at least 1 primary outcome: informed values choice, knowledge, accurate risk perception, decisional conflict subscales, and undecided.

Data Analysis

A network meta-analysis evaluated direct and indirect effects of PtDA attributes on primary outcomes.

Data Synthesis

Of 209 RCTs, 149 reported eligible outcomes. There was no difference in outcomes for PtDAs using implicit compared with explicit values clarification. Compared with PtDAs with probabilities, PtDAs without probabilities were associated with poorer patient knowledge (mean difference [MD] −3.86; 95% credible interval [CrI] −7.67, −0.03); there were no difference for other outcomes. There was no difference in outcomes when PtDAs presented information in ways that decrease cognitive demand and mixed results when PtDAs used strategies to enhance communication. Compared with PtDAs delivered in preparation for consultations, PtDAs used during consultations were associated with poorer knowledge (MD −4.34; 95% CrI −7.24, −1.43) and patients feeling more uninformed (MD 5.07; 95% CrI 1.06, 9.11). Involving patients in PtDA development was associated with greater knowledge (MD 6.56; 95% CrI 1.10, 12.03) compared with involving health care professionals alone.

Limitations

There were no direct comparisons between PtDAs with/without attributes.

Conclusions

Improvements in knowledge were influenced by some PtDA content elements, using PtDA content before the consultation, and involving patients in development. There were few or no differences on other outcomes.

Highlights

This is the first known network meta-analysis conducted to determine the contributions of the different attributes of patient decision aids (PtDAs) on patient outcomes. There was no difference in outcomes when PtDAs used implicit compared with explicit values clarification. There were greater improvements in knowledge when PtDAs included information on probabilities, PtDAs were used in preparation for the consultation or development included patients on the research team. There was no difference in outcomes when PtDAs presented information in ways that decrease cognitive demand and mixed results when PtDAs used strategies to enhance communication.
Bi-parametric MRI radiomic model for prostate cancer diagnosis: value of intralesional and perilesional radiomics
Authors: Li Yida , Zhou Xin , Zhang Xinyuan , Zhang Mengmeng , Sun Shengjian , Gai Xue , Li Guohua
Published: February 2025

Background

Prostate cancer (PCa) is the most common malignant tumor that endangers the life and health of middle-aged and elderly men.

Purpose

To evaluate the significance of radiomic features from intralesional and perilesional regions in bi-parametric magnetic resonance imaging (MRI) for diagnosing PCa.

Material and Methods

A total of 211 patients with suspected PCa who accepted prostate MRI scans were enrolled in this study. The region of interest (ROI) corresponding to the original lesion was manually delineated to define the intralesional ROI on bp-MRI maps. The original lesion ROI was then expanded by 2 mm, 4 mm, 6 mm, and 8 mm, while excluding the intralesional area to create the perilesional ROI. Features were extracted from each ROI, and a radiomics model was developed using logistic regression. The combined model integrated features from both intralesional and perilesional regions. Its predictive performance was assessed using receiver operating characteristic (ROC) curves and area under the curve (AUC) to evaluate its diagnostic efficacy for PCa.

Results

The comparison revealed that perilesional 4 mm model had the best performance among all perilesional models, its AUCs of 0.934 and 0.894 in the training testing set, respectively, outperformed the combined model of other regions. The clinical model, combined model for intralesional regions, and INTRAPERI model achieved AUCs of 0.911, 0.925, 0.931 in the training sets and 0.770, 0.867, 0.905 in the testing sets. The predictive performance of the INTRAPERI model is better than the clinical model and intralesional model.

Conclusion

The radiomic model combining intralesional and perilesional features from bi-parametric MRI shows strong predictive value for PCa and may enhance clinical decision-making.
Preconditioned block Kaczmarz methods for linear equations with an application to computed tomography
Authors: Liu Duo , Wang Wenli , Qu Gangrong
Published: February 2025

Background

Preconditioned Kaczmarz methods play a pivotal role in image reconstruction. A fundamental theoretical question lies in establishing the convergence conditions for these methods. Practically, devising an efficient block strategy to accelerate the reconstruction process is also critical.

Objective

This paper aims to introduce the convergence conditions for the preconditioned Kaczmarz methods and design the block strategy with corresponding preconditioners for these methods in computed tomography (CT).

Methods

We establish a kind of useful convergence conditions for the preconditioned block Kaczmarz methods and prove the dependence of the convergence limit on the initial guess. Tailored for the CT problem, we also propose a new method with a novel block strategy and specific preconditioners, which ensure accelerated convergence.

Results

Numerical experiments with the Shepp-Logan phantom and a real chest CT image demonstrate that our proposed block strategy and preconditioners effectively accelerate the reconstruction process by the preconditioned block Kaczmarz methods while maintaining satisfactory image quality.

Conclusions

Our proposed method, which incorporates the designed block strategy and specific preconditioners, has superior performance compared to the traditional Landweber iteration and the block Kaczmarz iteration without preconditioners.
Looks are deceiving: An uncommon cause of milky white peritoneal dialysis effluent
Authors: Esteves Alexandra , Pimenta Ana Carolina , Santos Lídia , Reis Marina , Cerqueira Sofia , Maia Pedro , Alves Rui
Published: February 2025

Peritoneal dialysis effluent should be clear and any changes in aspect require further investigation. We report a case of a spontaneous milky white effluent (chyloperitoneum) associated with calcium channel blockers in a peritoneal dialysis patient. Our case is a 43-year-old man that presents with milky white peritoneal dialysis effluent 9 days after starting peritoneal dialysis. He didn't have any other complaints and he wasn't prescribed any new medications. In the effluent sample we found high triglycerides (1.8 mmol/L) thus confirming the chyloperitoneum. We suspended lercanidipine and within a few days the peritoneal dialysis effluent was clear. Currently the patient is well adjusted to the technique and had no further episodes of chyloperitoneum.
Westermarck and Malinowski: Friendship and competition during an intellectual paradigm shift
Authors: Lagerspetz Olli , Suolinna Kirsti
Published: February 2025

This article highlights the personal and intellectual relationship between Bronisław Malinowski and Edvard Westermarck. In the interwar period, social anthropology went through a paradigm shift from evolutionism to functionalism. Malinowski put himself forward as a reformer, in contrast with Westermarck's more conservative and conciliatory approach. On the other hand, Malinowski always deferred to Westermarck and described himself as his disciple. Westermarck was Malinowski's teacher, his friend, and later his colleague at the London School of Economics. Our study of their personal and intellectual exchanges questions the traditional perception of a sudden intellectual revolution in social anthropology. The paradigm shift was essentially a change of perspective: a refocusing away from cross-cultural comparisons and towards intensive local studies. Westermarck, as a pioneer of fieldwork, contributed substantially to that development. His notion of social origins was close to Malinowski's notion of function. Thanks to their friendship and constant exchange of ideas, Westermarck became the bridge that connected evolutionism to Malinowski's brand of functionalism. Our chief primary source is their correspondence, with additional material by Westermarck's Finnish contacts.
Adaptive Fuzzy Global Non-singular Fast Terminal Sliding Mode Control for delta robot based on parameter optimization of Sparrow Search Algorithm
Authors: Liu Jian , Guo Zhongfeng , Yang JunLin
Published: February 2025

Aiming at the characteristics of nonlinearity, strong coupling and unknown perturbation in the dynamics model of Delta robot under high-speed operation, this paper designs a new Global Non-singular Fast Terminal Sliding Mode Control (GNFTSMC), which avoids the singularity of the traditional terminal sliding mode control. On this basis, Fuzzy Global Non-singular Fast Terminal Sliding Mode Control (FGNFTSMC) is proposed by combining Global Non-singular Fast Terminal Sliding Mode Control with fuzzy system, which is a method of eliminating the chattering of sliding mode controller by using fuzzy logic outputs instead of the reaching control law. To improve the trajectory tracking accuracy, the Adaptive Fuzzy Global Non-singular Fast Terminal Sliding Mode Control (AFGNFTSMC) is proposed by adjusting output gain online through the adaptive fuzzy system. The Sparrow Search Algorithm (SSA) is proposed to optimize the Adaptive Fuzzy Global Non-singular Fast Terminal Sliding Mode Control (AFGNFTSMC) sliding surface parameters and select the optimal sliding surface parameters. Experiments show that applying the Adaptive Fuzzy Global Non-singular Fast Terminal Sliding Mode Control optimized based on the SSA (SSA-AFGNFTSMC) to the Delta robot improves the tracking accuracy, reduces the convergence time and eliminates the controller output chattering.