bluuebunny/crossref_metadata_2025 huggingface dataset:
The Molecular Classification of Pheochromocytomas and Paragangliomas: Discovering the Genomic and Immune Landscape of Metastatic Disease
Authors: de Bresser Carolijn J. M. , de Krijger Ronald R.
Published: October 2024

Pheochromocytomas (PCCs) and paragangliomas (PGLs, together PPGLs) are the most hereditary tumors known. PPGLs were considered benign, but the fourth edition of the World Health Organisation (WHO) classification redefined all PPGLs as malignant neoplasms with variable metastatic potential. The metastatic rate differs based on histopathology, genetic background, size, and location of the tumor. The challenge in predicting metastatic disease lies in the absence of a clear genotype–phenotype correlation among the more than 20 identified genetic driver variants. Recent advances in molecular clustering based on underlying genetic alterations have paved the way for improved cluster-specific personalized treatments. However, despite some clusters demonstrating a higher propensity for metastatic disease, cluster-specific therapies have not yet been widely adopted in clinical practice. Comprehensive genomic profiling and transcriptomic analyses of large PPGL cohorts have identified potential new biomarkers that may influence metastatic potential. It appears that no single biomarker alone can reliably predict metastatic risk; instead, a combination of these biomarkers may be necessary to develop an effective prediction model for metastatic disease. This review evaluates current guidelines and recent genomic and transcriptomic findings, with the aim of accurately identifying novel biomarkers that could contribute to a predictive model for mPPGLs, thereby enhancing patient care and outcomes.
„Wenn ich bei ‚Wünsch Dir was‘ wäre“ …
Authors: Parchow Alexander , Mazı Havva , Rademaker Anna Lena , Makowsky Katja
Published: October 2024

Der Forschungsbereich „Reallabor Frühe Hilfen“ innerhalb des Projektes „TransCareTech“, angesiedelt an der Hochschule Bielefeld, verfolgt das Ziel in verschiedenen Forschungs- und Endwicklungsprojekten Innovationen sowie transformative Prozesse im interprofessionellen Handlungsfeld der Frühen Hilfen anzustoßen und zu begleiten. In der vorliegenden Teilstudie ging es bei einer Befragung von Fachkräften darum, mögliche Ansatzpunkte für eine Weiterentwicklung der Frühen Hilfen zu ermitteln. Der Beitrag nimmt Bezug auf die Ergebnisse der Studie und stellt Überlegungen zu möglichen Neuerungen in den Frühen Hilfen dar.
Co-Funding Robust Monitoring with Living Shoreline Construction is Critical for Maximizing Beneficial Outcomes
Authors: Baker Ronald , Gittman Rachel K.
Published: October 2024

Huge sums of money (billions) are being spent to combat the loss of valuable coastal ecosystems and human infrastructure through the stabilization of shorelines. The last several decades have seen a large push towards the implementation of nature-based approaches, or living shorelines (LS), that seek to both stabilize shorelines and promote or enhance ecosystem functions and services. A growing body of research has demonstrated ecological benefits of LS restorations. However, our ability to identify specific LS designs or features that most enhance particular ecosystem functions or services remains limited. As a result, we can provide limited guidance on the best designs for future LS projects that will maximize their ecological benefits, and therefore return on investment. Every restoration project is essentially an experiment that can provide rich knowledge of the ecological outcomes, but only if the relevant research and monitoring is properly funded and that information is made widely available to practitioners. Despite the investment of billions of dollars into LS projects, considerably fewer funds are being directed towards research, monitoring, and assessment of these projects. In many cases, funding for monitoring only becomes available after the projects are installed, meaning we are frequently forced to use space-for-time substitution rather than more rigorous and robust designs that include sampling before construction. We call for funding agencies to embed funding for robust monitoring and assessment of these projects, to allow for a greater understanding of the successes and failures, and to more wisely guide future projects.
Performance of Seismically-Compatible Fin Plate Joints under Fire Conditions
Authors: Chen Gordon , Abu Anthony , MacRae Gregory
Published: October 2024

This paper compares the performance of fin plate joints designed with and without seismic considerations under gravity loading and fire conditions. The non-seismic design, following British detailing provisions, has a thicker fin plate located higher on the beam web and it positions the beam web closer to the column face compared to the seismic design detail based on New Zealand provisions. Finite elements in ABAQUS are used to model the subassembly, which is subjected to the ISO 834 fire with and without a cooling phase. The analyses indicate the same failure mode in both subassemblies, with yielding at the beam web top bolt hole in bearing and fracture of the top bolt in shear. However, under the same fire regime, peak compressive and moment demands of the seismic detail were approximately 25% less than those for the non-seismic detail. When subjected to heating only, time to runaway failure was similar for the seismic and non-seismic detail, occurring at 15.0 and 14.8 min into the analyses respectively. When a cooling phase was included, beginning 10 min after initial fire exposure, both subassemblies recovered without failure. A parametric study showed a larger gap between the beam end and column face decreased compression in the beam but did not significantly affect the failure characteristics of the joint. Use of thicker fin plates was also found to increase the time to failure. The results show that the seismic detailing provides limited improvement over the non-seismic detail for the analysed fin plates.
Mode selective damping behavior of additively manufactured beam structures
Authors: Oel Marcus , Kleyman Gleb , Jonkeren Mirco , Tatzko Sebastian , Ehlers Tobias
Published: October 2024

Additive manufacturing, with its inherent process-related degrees of freedom, offers significant potential for manufacturing high-performance parts. This allows effects to be integrated that enable completely new solution mechanisms for existing conflicting objectives, which means that the degrees of design freedom make it possible to optimize the application-specific behavior of a part. In addition to the thermal or electrical properties, the dynamic behavior of a part can also be optimized, for example. This article focuses on the integration of the particle damping effect, which can contribute significantly to increased part damping. Unfused powder inside the part leads to energy dissipation through impact and friction mechanisms. However, the particle damping effect is not yet fully explored, lacking essential knowledge for application in product design. Therefore, test specimens with particle dampers, manufactured using laser powder bed fusion by laser beam from 1.2709 tool steel, are investigated, with variations in the position and size of the particle-filled cavities. To determine damping, the samples are freely supported and excited with an impulse. The damping ratio is calculated based on the recorded decay behavior. The results show an increase in damping ratio of up to a factor of 70, with the extent of improvement strongly dependent on the cavity’s volume and, crucially, its position relative to the part’s mode shape. A linear relationship between the damping ratio and the displacement of the volume of the cavities of the beams is shown.
Quantifying Residual Soil Moisture through Empirical Orthogonal Functions Analysis to Support Legume-Based Cropping Systems
Authors: Jimma Tamirat B. , Abera Wuletawu , Demissie Teferi , Spillane Charles , Ture Kassahun , Solomon Dawit , Chemura Abel
Published: October 2024

This study investigates spatiotemporal variability of residual soil moisture during the OND (October-November-December) season in Ethiopia and its implications for crop productivity. Employing advanced statistical techniques, we analyze spatial and temporal distribution of soil moisture across Ethiopia from 1981 to 2020, focusing on selected crops including legumes: chickpea, field peas, common bean, soybean and alfalfa, to assess the potential of residual moisture to support post-rainy season cropping. Results indicate pronounced east-west moisture gradients, with eastern regions of Ethiopia exhibiting lower moisture levels (< 60 kg.m-2) compared to western regions (> 150 kg.m-2). The central highlands, which are pivotal for agricultural activities, demonstrate significant variability in moisture (standard deviations > 25 kg.m-2), with implications on agricultural sustainability. The northern and southeastern tips of the country are particularly vulnerable to prolonged drought, where climate change and frequent dry spells exacerbate moisture deficits, consequently impacting crop productivity. Despite these challenges, promising opportunities for future crop production emerge in the southeastern region, which is characterized by increasing moisture trend over time ($$\:\tau\:=0.59$$). Findings further indicate that residual moisture adequately meets and supports crop water requirements in the western, central, and southwestern Ethiopia. In these regions, residual moisture supports more than 90% of cropland water requirements of various crops during the initial and late-season growth stages, whereas water requirement coverage drops to less than 20% during the mid-season growth stage. Therefore, by utilizing residual soil moisture alongside supplemental irrigation, Ethiopian farmers can meet crop water needs for double cropping and enhance resilience to climate variability.
Changing the Record? The (re)Making of Rock ‘n’ Roll, ‘Race’ and Teenage Leisure in 1950s Cleveland
Authors: Lashua Brett D. , Thompson Paul
Published: October 2024

This paper aims to explore, and reframe, the relations between rock ‘n’ roll, leisure, ‘race’ and youth in Cleveland, Ohio in the 1950s, utilizing archival research to question the heritagization of the city’s popular music histories. Specifically drawing upon accounts of radio broadcasting and vinyl records, we offer an archival study of Cleveland, Ohio, a city that claims to be the “birthplace of rock ‘n’ roll” and (since 1986) is the site of the Rock and Roll Hall of Fame and Museum. After contextualizing the 1950s, we conceptualize the recent archival (re)turn in socio-cultural research. Through this methodological lens we overview the special collections, documents and artefacts explored in fieldwork at the Rock and Roll Hall of Fame’s Library and Archives. Then, three counter-stories are presented toward decentring and demythologizing the canonical history of rock ‘n’ roll in Cleveland. Against this canonization, we “change the record” of histories of local radio broadcasting, record stores and eyewitness accounts from Cleveland’s black teenage audiences often absent from many authorized heritage discourses of early rock ‘n’ roll. In deconstructing myths of Cleveland’s musical past, the paper frames archival research as a critical, if under-utilized resource, in leisure research.
32 years of changes in river paths and coastal landscape in Bangladesh, Bengal Basin
Authors: Shahid Shahriar Bin , Gani M. Royhan , Gani Nahid D.
Published: October 2024

This study examines the geomorphological changes and environmental impacts on the coastline and the evolution of major river systems in Bangladesh over the past 32 years using remote sensing and GIS analyses. The central coastal area, characterized by fine sediments, has experienced significant land erosion due to the dynamics of the Meghna Estuary and its depositional patterns. In contrast, the southwestern Sundarbans Forest coast has remained relatively stable, aided by mangrove root stabilization despite anthropogenic threats. Channel migration analysis revealed the Brahmaputra River’s persistent braided configuration, while its tributaries, Teesta and Dharla, increased meandering nature due to reduced water availability and human interventions. The Ganges-Padma system displayed a shift towards a more sinuous channel pattern driven by reduced water discharge due to the Farakka Barrage construction in the upstream and a minor decrease in precipitation. The Upper Meghna River maintained moderate sinuosity with stable anastomosed patterns, whereas the lower Meghna River’s convergence with the Jamuna and Padma Rivers increased its susceptibility to erosion. These findings highlight the interplay of natural processes and human activities in shaping the coastal and fluvial landscapes of Bangladesh and the Bengal Basin, emphasizing the need for sustainable land-use practices and adaptive management strategies to mitigate future risks associated with sea-level rise and river course changes.
Mental health needs of tribal college students in Araku Valley
Authors: Karuturi Rishitha Swathi , Kandi Suneetha
Published: October 2024

The indigenous tribal population in India, often residing in remote and underserved regions, represents a marginalized minority with limited access to healthcare, particularly mental health services. Despite the pressing need, there is a scarcity of research focusing on the mental health challenges faced by adolescents and young adults within these communities. This study addresses this gap by examining the mental health needs of tribal college students in the Araku Valley region of Andhra Pradesh, India. The study sample comprised 291 participants (118 males, 173 females), representing adolescents and young adults from various tribal backgrounds. Utilizing the Students Counseling Needs Questionnaire and the General Health Questionnaire-30, the study identified alarmingly high prevalence rates of mental health concerns, including uncontrollable disturbing thoughts (73.18%), loneliness (62.19%), depression (57.04%), phobias (54.97%), and suicidal ideation or attempts (39.16%). Notably, the study revealed a trend of decreasing mental health needs with advancing age, suggesting that adolescents are more vulnerable than young adults. Furthermore, significant gender differences were observed, with female students reporting higher family-related needs compared to male students. These findings provide critical insights into the mental health challenges faced by tribal college students and have important implications for policy development and educational practices aimed at addressing the unique needs of this population. Educators at tribal institutions can use these findings to address the mental health needs of tribal students.
GNSS interference detection: Methodology utilising ADS-B NACp indicator and GPS almanac data
Authors: Pleninger S. , Topkova T. , Steiner J.
Published: October 2024

The threat of GNSS interference poses a great danger to many critical infrastructure systems including air navigation. With a focus on mitigating this threat, this paper proposes a methodology for detecting GNSS interference. The methodology utilises the quality indicator NACp transmitted in ADS-B messages and GPS almanac data for interference detection. The NACp indicator enables estimation of the position error derived from GPS, which is compared with the HDOP value of the GPS satellite constellation. Based on this comparison, the developed detection algorithm determines whether the aircraft is affected by jamming. The detection methodology is evaluated on datasets obtained during deliberate experiments with GPS jamming. The proposed methodology provides a way to detect GNSS interference, facilitating mitigation of its impact on air traffic operation.
Duke Research at Pickett: The evolution of a free-standing research site partnering with communities toward health equity advancement
Authors: Van Althuis Laura , Taylor Sally , Freeman Debra , Freel Stephanie , Sutton Lynn , Bethea Kenisha , Martin Leatrice , McMillan Amanda , Williams Garber Diane , Bentley-Edwards Keisha , Barrett Nadine , Snyder Denise C. , Naggie Susanna
Published: October 2024

While clinical research intends to improve health outcomes for all, access to research participation is often limited and inequitable. Geographic proximity is a recognized barrier, thus, systemic infrastructure solutions through federal programs including General Clinical Research Centers and Clinical and Translational Science Awards have sought to improve accessibility. Even with such support, academic medical centers often have limited clinical research-dedicated space apart from shared exam rooms in difficult-to-navigate hospitals or clinics. In 2019, the Duke University School of Medicine looked beyond its medical center campus to identify free-standing sites within Durham communities for participant study visits. Catalyzed by the COVID-19 pandemic, Duke Research at Pickett, a 22 000-square-foot building with a laboratory, 30 exam rooms, and on-site parking, opened in October 2020 to support vaccine and treatment trials. Upon the lifting of many COVID-19 restrictions, and in partnership with the Research Equity and Diversity Initiative (READI) Community Advisory Council, the building was transformed to encourage community gatherings, education, and training programs. To date, Duke Research at Pickett has hosted 2692 participants in 78 research trials and 14 community-engaged activities.
Improvement of the Surveillance Protocols After Experiencing a Pseudo-Epidemic After 2018 Central Sulawesi Earthquake in Indonesia
Authors: Pane Masdalina , Purnama Tri Bayu , Sulasmi Sri , Rahman M. Aulia , Maemun Siti , Pandita Hadijah , Tenrisau M. Dhihram , Sittimart Manit
Published: October 2024

Objective

Following a disaster, a pseudo-epidemic can occur due to redundant and duplicated data caused by infrastructure and information system disruptions. This study aims to investigate whether there have been improvements the post-disaster surveillance system in the comparison of diarrhea incidents between Central Sulawesi, Indonesia, and Cianjur, West Java, Indonesia.

Methods

We conducted an analysis of the epidemic-prone disease diarrhea before and during disasters, comparing the data with secondary data from the Early Warning Alert and Response System (EWARS) and the District Health Information System V.02 (DHIS-2).

Results

In central Sulawesi in 2018 and Cianjur in 2022, we observed an upsurge in diarrhea cases in the first week after the disaster. Although diarrhea cases increased after the disaster, they remained within acceptable outbreak criteria. Multiplication and redundant data were detected in the DHIS-2 system in Central Sulawesi, likely leading to erroneous overreporting. Changes in surveillance officers and their personal experiences during the disaster contributed to data inconsistencies. As compared to Central Sulawesi, the DHIS-2 reporting form in Cianjur was simplified as an individual form to enhance efficiency and accuracy.

Conclusions

Enhancing valid assessment and conducting thorough investigations are essential to improve surveillance protocols for epidemic-prone diseases following disasters.
Relationship between early traumatic experiences and emotional regulation skills in major depressive and bipolar disorders
Authors: Park Yejin , Lee Chan Woo , Jang Yoonjeong , Kwon Sarah Soonji , Yu Hyeona , Yoon Joohyun , Park Yun Seong , Ryoo Hyun A. , Jang Junwoo , Lee Hyuk Joon , Lee Yeong Chan , Won Hong-Hee , Ha Tae Hyon , Myung Woojae
Published: October 2024

Childhood trauma can cause deficits in emotional regulation. However, few studies have investigated childhood trauma and emotional regulation skills in patients with mood disorders. We aimed to investigate how childhood trauma and Emotion Regulation Skills Questionnaire (ERSQ) scores are associated with mood disorders.

This study included 779 patients with mood disorders (major depressive disorder [MDD, n = 240], bipolar I disorder [BDI, n = 121], and bipolar II disorder [BDII, n = 418]). We used their Childhood Trauma Questionnaire-Short Form (CTQ) and ERSQ scores for the evaluation.

The between-group differences in CTQ and ERSQ scores were examined. The CTQ and ERSQ total scores were negatively correlated. Among the CTQ subscales, emotional neglect showed a significant correlation with the ERSQ total score, whereas acceptance and tolerance showed higher negative correlations with the CTQ than with the other ERSQ subscales. The negative relationship between emotional regulation and childhood trauma varied significantly depending on the group, with the BDI group showing a more prominent association than the other groups.

Based on various mood disorders, we observed associations between childhood trauma and emotional regulation skills. Consequently, our study offers notable insights for future research on the impact of childhood trauma on ERSQ.
Growth trajectory at 24 months of preterm infants after discharge: a longitudinal study in Indonesia
Authors: Rohsiswatmo Rinawati , Hikmahrachim Hardya Gustada , Nadobudskaya Dinarda Ulf , Iskandar Adhi Teguh Perma , Marsubrin Putri Maharani Tristanita , Sukarja Distyayu , Sjahrulla Muhamad Azharry Rully , Kautsar Ahmad , Sutrisno Audesia Alvianita , Roeslani Rosalina Dewi
Published: October 2024

Maintaining optimal growth of preterm infants after hospital discharge remains a challenge. There has been no data on the long-term growth trajectory of preterm infants in Indonesia. We aimed to describe the growth trajectory of preterm infants up to 24 months of corrected age and its variation among gestational age groups. A longitudinal study was conducted in Cipto Mangunkusumo Hospital, Jakarta, from 2018 to 2020. All preterm infants who were discharged during the study period were included. Growth trajectory analysis used weight-for-age, length-for-age and weight-for-length z-score of 3-month time intervals across gestational age groups using repeated measure ANOVA and generalised estimating equation regression. Length trajectory was specifically reported as a stunted proportion. Among 306 preterm infants included, most were moderate preterm (49·67 %) and low birth weight (69·93 %). Overall weight-for-age at 0 months was in the median of the curve, then decreased at 3 months but consistently increased slowly until 24 months. The weight-for-age trends were unique across gestational age groups but statistically similar (P= 0·263). The proportion of stunted gradually decreases to 13·40 % at 24 months, mostly among the moderate preterm group in the first 6 months (P< 0·001), but then becomes similar at 24 months. All subjects were in the normal range for weight-for-length but had variations in trends across gestational age groups (P< 0·001). Growth trajectory differed between weight, length and weight-for-length in the first 24 months and varied among gestational age groups. Close follow-up is crucial to ensure optimal growth after neonatal intensive care unit discharge.
Transcriptomic analysis of the gonads of Locusta migratoria (Orthoptera: Acrididae) following infection with Paranosema locustae
Authors: Kong Xuewei , Guo Xinrui , Lin Jun , Liu Hui , Zhang Huihui , Hu Hongxia , Shi Wangpeng , Ji Rong , Jashenko Roman , Wang Han
Published: October 2024

Paranosema locustae is an environmentally friendly parasitic predator with promising applications in locust control. In this study, transcriptome sequencing was conducted on gonadal tissues of Locusta migratoria males and females infected and uninfected with P. locustae at different developmental stages. A total of 18,635 differentially expressed genes (DEGs) were identified in female ovary tissue transcriptomes, with the highest number of DEGs observed at 1 day post-eclosion (7141). In male testis tissue transcriptomes, a total of 32,954 DEGs were identified, with the highest number observed at 9 days post-eclosion (11,245). Venn analysis revealed 25 common DEGs among female groups and 205 common DEGs among male groups. Gene ontology and Kyoto Encyclopaedia of Genes and Genome analyses indicated that DEGs were mainly enriched in basic metabolism such as amino acid metabolism, carbohydrate metabolism, lipid metabolism, and immune response processes. Protein–protein interaction analysis results indicated that L. migratoria regulates the expression of immune- and reproductive-related genes to meet the body's demands in different developmental stages after P. locustae infection. Immune- and reproductive-related genes in L. migratoria gonadal tissue were screened based on database annotation information and relevant literature. Genes such as Tsf, Hex1, Apolp-III, Serpin, Defense, Hsp70, Hsp90, JHBP, JHE, JHEH1, JHAMT, and VgR play important roles in the balance between immune response and reproduction in gonadal tissues. For transcriptome validation, Tsf, Hex1, and ApoLp-III were selected and verified by quantitative real-time polymerase chain reaction (qRT-PCR). Correlation analysis revealed that the qRT-PCR expression patterns were consistent with the RNA-Seq results. These findings contribute to further understanding the interaction mechanisms between locusts and P. locustae.
Potential biomarkers for lameness and claw lesions in dairy cows: A scoping review
Authors: Sadiq Mohammed B. , Ramanoon Siti Z. , Mansor Rozaihan , Shaik Mossadeq Wan Mastura , Syed-Hussain Sharifah Salmah , Yimer Nurhusien , Kaka Ubedullah , Ajat Mokrish , Abdullah Jesse Faez Firdaus
Published: October 2024

One of the major challenges in lameness management is prompt detection, especially before visible gait disturbance. This scoping review describes the potential biomarkers for lameness in dairy cows reported in the literature, their relevance in lameness diagnosis, identifying cows at risk of developing claw lesions and monitoring recovery after treatment. Using specific keywords, a comprehensive literature search was performed in three databases: PubMed, Google Scholar and ScienceDirect to retrieve relevant articles published between 2010 and 2022. A total of 31 articles fulfilling the inclusion criteria were analysed. The categories of potential markers for lameness reported in the literature included acute phase proteins (APPs), nociceptive neuropeptides, stress hormones, proteomes, inflammatory cytokines and metabolites in serum, urine and milk. Cortisol, APPs (serum amyloid A and haptoglobin) and serum, urinary and milk metabolites were the most studied biomarkers for lameness in dairy cows. While APPs, nociceptive neuropeptides and blood cortisol analyses assisted in elucidating the pain and stress experienced by lame cows during diagnosis and after treatment, evidence-based data are lacking to support their use in identifying susceptible animals. Meanwhile, metabolomic techniques revealed promising results in assessing metabolic alterations occurring before, during and after lameness onset. Several metabolites in serum, urinary and milk were reported that could be used to identify susceptible cows even before the onset of clinical signs. Nevertheless, further research is required employing metabolomic techniques to advance our knowledge of claw horn lesions and the discovery of novel biomarkers for identifying susceptible cows. The applicability of these biomarkers is challenging, particularly in the field, as they often require invasive procedures.
Review of contemporary fluorescence correlation spectroscopy method in diverse solution studies
Authors: Jovičić Snežana M
Published: October 2024

Fluorescence correlation spectroscopy (FCS) is a well-known and established non-invasive method for quantification of physical parameters that preside over molecular mechanisms and dynamics. It combines maximum sensitivity and statistical confidence for the analysis of speed, size, and number of fluorescent molecules and interactions with surrounding molecules by time-averaging fluctuation analysis in a well-defined volume element. The narrow compass of this study is to acquaint the basic principle of diffusion and the FCS method in general regarding variable magnitudes and standardization adjustment. In this review, we give a theoretical introduction, examples of experimental applications, and utensils in solution systems with future perspectives.
Knowing what you want–why disembodied repentance is impossible
Authors: Rooney James Dominic
Published: October 2024

It is a reasonable worry that God would not truly love us and want our salvation if He fixed a definite point after which He will no longer offer us the graces to repent of our sins. I propose that Thomas Aquinas succeeds in showing us that God would not be cruel or arbitrary in setting up a world where embodied agents end up after death in a state where they will inevitably fail to repent of their sins. Aquinas proposes that being disembodied is to be in a state where a person cannot be mistaken about what they want, given that they know themselves perfectly. If the disembodied state were like this, it would not be surprising that being in that state makes repentance impossible, since a soul would become fully integrated around whatever one desired, without any conflicting desires that could prompt repentance. Thus, humans would persist in whatever desires they had at the moment of death and disembodiment. I conclude by arguing that, while this scenario stands in need of fuller theodicy, Aquinas’s scenario is helpful in defending a view that God is not cruel or arbitrary for creating a world in which post-mortem repentance is impossible.
THE ‘SWORD BEARERS’: WOMEN BEARING SWORDS? RETHINKING A GROUP OF FIGURES IN MYCENAEAN PICTORIAL VASE PAINTING
Authors: Antognelli Michel Nicoletta
Published: October 2024

This paper focuses on a particular group of human figures attested on a number of Late Helladic (LH) IIIA2–B1 pictorial kraters which show specific attributes: they have long hair, wear an elaborate cloak-like robe and bear a sword on their chest. Furthermore, they appear in clearly peaceful representations like chariot or processional scenes. These accurately rendered ‘Sword Bearers’ have so far been assumed to be of male sex due to the presence of the sword; the interpretation proposed here, that they are women, is based on the presence of distinctive female traits as also found on female representations on pictorial vessels and other media of the same period. Particularly striking is the similarity with the enigmatic ‘Sword Bearer’ from the Cult Centre of Mycenae, who is the sole contemporary model of a female figure with a sword wrapped in a long cloak. Though not postulating that these figures are female warriors, attention will be drawn to the fact that weapons have a strong association to the female imagery as well to the sphere of ritual – a sphere in which women played, as is well known, a predominant role in Aegean culture.
Penumbra Indigo® system to safely remove intracardiac thrombus in a 7-month-old infant with severe immunodeficiency disorder
Authors: Haddad Raymond N. , Adel Hassan Ahmed , Al Soufi Mahmoud , Kasem Mohamed
Published: October 2024

We report on a 7-month-old boy (4.2 kg/60 cm) with severe immunodeficiency disorder and bacterial septicaemia who was referred for an infected atrial thrombus secondary to a jugular central line. The echocardiogram showed a teardrop-shaped thrombus with a wide base adherent to the interatrial wall and a flimsy tail moving freely in the right atrium. Chest CT scan showed multiple lesions in both lungs consistent with infected micro-thrombi. The thrombus increased in size despite 2 weeks of antibiotics and anticoagulation. We applied the Indigo® Lightning® 7 aspiration system from Penumbra® (Alameda, USA) and removed percutaneously the thrombus under transoesophageal ultrasound and biplane fluoroscopic guidance. At 6 weeks of follow-up, the patient is alive, under enoxaparin with no procedure-related complication.
Intergenerational transfers, differential fertility, and wealth inequality
Authors: Cooke Aaron , Ghimire Umesh , Lee Hyun , Zhao Kai
Published: October 2024

Rising income and wealth inequality across the developed world has prompted a renewed focus on the mechanisms driving inequality. This paper contributes to the existing literature by studying the impact from life-cycle savings, intergenerational transfers, and fertility differences between the rich and the poor on the wealth distribution. We find that bequests increase the level of wealth inequality and that fertility differences between the rich and the poor amplify this relationship. The counterfactual exercises show that the interaction between bequests and differential fertility is quantitatively important for understanding wealth inequality in the United States.
Study accretion and ejection using a new GPU-accelerated GRMHD code
Authors: Pe’er Asaf , Bégué Damien , Zhang Guoqiang
Published: October 2024

We study disks and jets in various accretion states (SANE and MAD) using novel, GPU-accelerated general-relativistic magneto-hydrodynamic (GR-MHD) code which we developed, based on HARM. This code, written in CUDA-c and uses OpenMP to parallelize multi-GPU setups, allows high resolution simulations of accretion disks and the formation and structure of jets without the need of multi-node supercomputer infrastructure. A 2563 simulation is well within the reach of an Nvidia DGX-V100 server, with the computation being a factor about 100 times faster if only the CPU was used.

We use this code to examine several disk structures, wind and jet properties in the MAD and SANE states. In the MAD state, we find that the magnetic flux threading the horizon mostly depends on the spin of the BH. This implies that the jet structure and power are strong functions of the spin, with non-spinning BHs have the widest jets.
High energy processes in common envelope jets supernovae
Authors: Grichener Aldana
Published: October 2024

We study high energy processes that occur during the merger of a neutron star (NS) or a black hole (BH) with the core of a red supergaint (RSG). The merger powers a luminous event termed common envelope jets supernova (CEJSN), that might account for lightcurves of peculiar transients. In the CEJSN scenario the NS/BH accretes mass from its surroundings through an accretion disk as it spirals-in inside the RSG’s envelope and core. The compact object launches part of this mass as narrow jets that interact with their environment by depositing their kinetic energy in the envelope and core gas. These jets can serve as production sites of high energy neutrinos and r-process elements.
Outflows from black hole accretion flows with various accretion rates
Authors: Bu De-Fu , Yuan Feng
Published: October 2024

Both observations and theoretical studies have convincingly shown that outflows (i.e., wind and jet) are common phenomena from black hole accretion systems with various accretion rates, although the physical driving mechanisms are not exactly same for different accretion modes. Outflows are not only important in the dynamics of black hole accretion, but also play an important role in AGN feedback; therefore it is crucial to investigate their main physical properties including mass flux and velocity. In this paper we summarize recent studies in investigating the properties and driving mechanisms from black hole accretion flows with various accretion rates.
Ram-pressure induced radial inflows of gas to the galaxy centre
Authors: Akerman Nina , Tonnesen Stephanie , Poggianti Bianca Maria , Smith Rory , Marasco Antonino
Published: October 2024

Ram-pressure stripping (RPS) is a process known to remove gas from satellite galaxies. Recent observational studies have found an increased ratio of active galactic nuclei (AGN) among the population of RPS galaxies compared to regular galaxies in the field. To test whether ram pressure (RP) can trigger an AGN, we perform a suite of hydrodynamical wind-tunnel simulations of a massive (Mstar = 1011Mȯ) galaxy, with inclusion of star formation, stellar feedback and high resolution up to 39 pc. We find that RP increases the inflow of gas to the galaxy centre, which in turn can result in the enhanced BH accretion, as measured by the Bondi-Hoyle model. We also estimate pressure of outflows from our accretion rates and show that AGN feedback would play an important role on the early stages of stripping, while RP itself is not so strong.
The role of outflows in black-hole X-ray binaries
Authors: Kylafis Nikolaos D. , Reig Pablo
Published: October 2024

. An outflow, from the hot inner flow, in black-hole X-ray binaries is always expected due to the positive Bernoulli integral in the hot inner flow. We have demonstrated that, if one considers this outflow as the place where not only Comptonization occurs, but also radio emission, many observed correlations, including the long-standing one between radio and X-rays, can be explained with one simple model.
Mutualism: a model for managing risk in P2P sharing
Authors: Zhu Sally
Published: October 2024

This article explores how the risk structure currently adopted by the sharing economy, in particular the highly formalised and contrived systems of contract constructed by platforms, is largely constituted by the rules of property law. This effectively ties sharing activities to the old model of private property and its accompanying boundaries of privatised risk and value and undermines the efforts of collaboration to supersede those boundaries through peer-to-peer co-production of value. This article aims towards presenting an alternative model of risk distribution for the sharing economy that is more reflective of its collaborative nature. To this end, I will draw on ideas from commons and mutualism and propose the possibility of creative use of contracts to stipulate positive duties and obligations between collaborative partners as a device to construct a collective and/or mutual risk system.
Mediating pathways between attention deficit hyperactivity disorder and type 2 diabetes mellitus: evidence from a two-step and multivariable Mendelian randomization study
Authors: Zhang J. , Chen Z. K. , Triatin R. D. , Snieder H. , Thio C. H. L. , Hartman C. A.
Published: October 2024

Aims

Type 2 diabetes (T2D) is a global health burden, more prevalent among individuals with attention deficit hyperactivity disorder (ADHD) compared to the general population. To extend the knowledge base on how ADHD links to T2D, this study aimed to estimate causal effects of ADHD on T2D and to explore mediating pathways.

Methods

We applied a two-step, two-sample Mendelian randomization (MR) design, using single nucleotide polymorphisms to genetically predict ADHD and a range of potential mediators. First, a wide range of univariable MR methods was used to investigate associations between genetically predicted ADHD and T2D, and between ADHD and the purported mediators: body mass index (BMI), childhood obesity, childhood BMI, sedentary behaviour (daily hours of TV watching), blood pressure (systolic blood pressure, diastolic blood pressure), C-reactive protein and educational attainment (EA). A mixture-of-experts method was then applied to select the MR method most likely to return a reliable estimate. We used estimates derived from multivariable MR to estimate indirect effects of ADHD on T2D through mediators.

Results

Genetically predicted ADHD liability associated with 10% higher odds of T2D (OR: 1.10; 95% CI: 1.02, 1.18). From nine purported mediators studied, three showed significant individual mediation effects: EA (39.44% mediation; 95% CI: 29.00%, 49.73%), BMI (44.23% mediation; 95% CI: 34.34%, 52.03%) and TV watching (44.10% mediation; 95% CI: 30.76%, 57.80%). The combination of BMI and EA explained the largest mediating effect (53.31%, 95% CI: −1.99%, 110.38%) of the ADHD–T2D association.

Conclusions

These findings suggest a potentially causal, positive relationship between ADHD liability and T2D, with mediation through higher BMI, more TV watching and lower EA. Intervention on these factors may thus have beneficial effects on T2D risk in individuals with ADHD.
Integrating mechanical and cultural methods for weed control in organic chickpea
Authors: Miller Zachariah J. , Hubbel Kyrstan
Published: October 2024

The Northern Great Plains of the United States is a major production region for organic pulse crops that are prone to yield losses due to weeds. Weed management in organic systems relies on the integration of several tactics to stack additive effects and for redundancy to deal with variable efficacy of individual weed management practices. To address the need for effective, integrated weed management, we conducted a 2-yr trial that evaluated the effects of planting date, seeding rate, and preemergent weed control practices (shallow tillage and flame weeding) on weed biomass, crop density, and yield in organically managed chickpea (Cicer arietinum L.) in Montana. Stacking weed management practices increased yields. Early planting had the largest effects on yields, increasing them by 1.8- to 3.6-fold compared with planting 10 to 14 d later. Increasing the seeding rate from the standard rate (43 viable seeds m−2) by 50% increased yields by 47% from 889 to 1,304 kg ha−1. Both preemergent weed control practices increased yields by 40% to 50 % relative to the non-weeded controls. By integrating all three practices, yields of organic chickpea increased greater than 6-fold from 318 kg ha−1 in the controls to 2,006 kg ha−1. The effects of weed control treatments on midseason weed biomass were complex and variable. Although efficacy of the cultural (seeding rate and planting date) and physical (preemergent) treatments on weed biomass varied between years and when combined with other treatments, their full integration, that is, early planted, at higher seeding rate, and preemergent weed control, produced consistently lower weed biomass (84% reduction on average) compared with the standard grower practice (later planting, standard seeding rate, no preemergent weed control). The results lend support to the concept of integrating multiple weed management practices to achieve weed control and high yields in organically managed crops.
Blue Carbon Assessment in the Salt Marshes of the Venice Lagoon: Dimensions, Variability and Influence of Storm‐Surge Regulation
Authors: Puppin Alice , Tognin Davide , Paccagnella Michela , Zancato Mirella , Ghinassi Massimiliano , D’Alpaos Chiara , Marani Marco , D’Alpaos Andrea
Published: October 2024

Salt marshes are intertidal coastal ecosystems shaped by complex feedbacks between hydrodynamic, morphological, and biological processes. These crucial yet endangered environments provide a diverse range of ecosystem services but are globally subjected to high anthropogenic pressures, while being severely exposed to climate change impacts. The importance of salt marshes as “blue carbon” sinks, deriving from their primary production coupled with rapid surface accretion, has been increasingly recognized within the framework of climate mitigation strategies. However, large uncertainties remain in salt marsh carbon stock and sequestration estimation. In order to provide further knowledge in salt marsh carbon assessment and investigate marsh carbon pool response to management actions, we analyzed organic matter content in salt marsh soils of the Venice Lagoon (Italy) from 60 sediment cores to the depth of 1 m and estimated organic carbon stock and accumulation rates in different areas. Organic carbon stocks and accumulation rates were highly variable in different marshes, being affected by organic and inorganic inputs and preservation conditions. Our estimates suggest that the studied marshes store 17,108 ± 5,757 tons of carbon per square kilometer in top 1‐m of soil and can accumulate 85 ± 25 tons of carbon per square kilometer per year. However, flood regulation may reduce the annual marsh CO2 sequestration potential by more than 30%. Our results contribute valuable information for regional carbon assessments, reinforcing the need for integrated coastal management policies to preserve the ecosystem services of coastal environments, and underscore the importance of considering local variability and methodological variations.
Observations of Significant Ion Energy Outflows Associated With Cusp Ion Outflows and the Role of Poynting Flux as an Energy Source
Authors: Tian S. , Wygant J. R. , Cattell C. A. , Dombeck J. P. , Bortnik J.
Published: October 2024

The cusp ion outflow on Earth has been extensively studied for decades. However, the energy flux associated with the ion outflow, which is of equivalent importance to the number flux or mass flux, has been rarely studied. Here, we present the first systematic study on the cusp ion energy flux and the energy budget along the cusp magnetic flux tube using quasi‐conjunction observations from the Polar and Fast satellites. Significant ion energy fluxes (several 10s mW/ mapped to 100 km altitude) away from the Earth are frequently observed in the mid‐altitude cusp (3–6 Re). Observations at low altitudes (2 Re) show that the upward ion energy flux is associated with ion outflows originating from the ionosphere. In addition, we show that the ion outflows experience intense energization well above the ionosphere. The only possible energy source for this energization is the earthward Poynting flux in mid‐altitude. The electrons are accelerated downward and are another energy sink (not source). The altitude profile of the energy fluxes suggests a transition region between 2 and 4 Re where both ion heating and electron acceleration primarily occur and where significant Poynting flux is dissipated. Analysis of the E/B ratio shows that the Poynting flux is carried by both the Alfven waves and quasi‐static structures. The above results place important constraints on possible local ion energization mechanisms.
Single-cell transcriptomic analysis reveals dynamic activation of cellular signaling pathways regulating beige adipogenesis
Authors: Kyung Dong Soo , Lee Eunmin , Chae Sehyun , Son Yeonho , Moon Ye-Jin , Hwang Daehee , Kim Jong Kyoung , Lee Yun-Hee , Seong Je Kyung
Published: October 2024

PDGFRA+ cells have been identified as adipocyte stem cells (ASCs) that differentiate into beige adipocytes in white adipose tissue (WAT) following thermogenic stimuli. To elucidate the molecular heterogeneity of ASCs, we conducted single-cell transcriptomic profiling of PDGFRA+ cells isolated from the inguinal WAT (iWAT) of mice treated with the beta3 adrenergic receptor agonist CL316243. Single-cell RNA-seq revealed nine major clusters, which were categorized into four groups: resting, proliferating, differentiating, and adipogenic factor-expressing cells (AFECs). Trajectory analysis revealed sequential activation of molecular pathways, including the Hedgehog and Notch signaling pathways, during beige adipogenesis. AFECs expressed Dpp4 and did not differentiate into adipocytes in culture or after transplantation. Furthermore, genetic lineage tracing studies indicated that DPP4+ cells did not differentiate into adipocytes in iWAT during CL316243-induced beige adipogenesis. However, high-fat diet feeding led to the recruitment of adipocytes from DPP4+ cells in iWAT. Overall, this study improved our understanding of the dynamic molecular basis of beige adipogenesis and the potential contribution of DPP4+ adipocyte lineages to the pathological expansion of WAT during diet-induced obesity.