bluuebunny/crossref_metadata_2025 huggingface dataset:
The Impact of Computer-assisted Language Learning Training on Teachers’ Practices
Authors: Hedayati Mohsen , Reynolds Bronwyn , Bown Andy
Published: November 2018

This study investigated and identified the common computer-assisted language learning (CALL) teacher training types in the Iranian private language schools (PLSs), and their effectiveness in shaping and encouraging teachers’ use of new technologies. An exploratory mixed method approach was employed, and a total of 86 Iranian EFL (English as a foreign language) teachers participated in this study. The results indicated that teachers were primarily self-trained, in the absence of comprehensive CALL training provided by either PLSs or teacher training courses offered at university level. It was concluded that self-training had resulted in subsequent sporadic and non-systematic use of CALL by teachers.
An Approach to Digital Game-based Learning: Video-games Principles and Applications in Foreign Language Learning
Authors: Pitarch Ricardo Casañ
Published: November 2018

During the present decade, researchers and educators of different fields have increased their attention towards digital game-based learning. The rise of interest towards this approach is partially connected to some important technological advances during the same period of time, such as the Smartphone, enhanced Internet connection from mobile devices, diversity and spread of free and low-cost video-games and educational applications in e-stores, development of speech recognition systems and artificial intelligence, among others. More concretely, this research focuses on the area of foreign language learning, an educational field which requires that students gain not only a solid theoretical knowledge on grammar and vocabulary, but they also need to develop different communicative competences; and this implies rehearsing and experiencing the use of the target language. The purpose of this paper is to define some basic concepts related to digital game-based learning, such as gamification and serious games, and to introduce some theoretical principles on foreign language learning and acquisition through the use of video-games based on literature review. Finally, a connection among these elements will be discussed.
Image-text Relations in Junior High School EFL Textbooks in China: A Mixed-methods Study
Authors: (Kelly) LAI Haiyan
Published: November 2018

This study seeks to test the applicability of Martinec and Salway’s (2005) framework of image-text relations in school textbook discourse, and adopts mixed methods by combining quantification of thirteen categories in Martinec and Salway’s analytical framework with interpretations of the relations between visual images and verbal language in the six junior high school EFL textbooks to generalize multimodal trends in pedagogical discourse. The findings shed some light on cultivating students’ multimodal literacy in the pedagogical context of Mainland China.
Strategy of Diffusion and Its Impacts on the Translation of Meditation Text
Authors: Susini Made , Sudipa I Nengah , Suparwa I Nyoman , Puspani Ida Ayu Made
Published: November 2018

This research concerns with the strategy of diffusion applied in the translation of Indonesian meditation text into English. Applying SFL of Halliday (2014), translation as re-contextualization (House, 2015) and translation strategies (Malone, 1988), it focuses on the impacts of the strategy of diffusion upon the target text transitivity structure and clause types. The result of this research shows that the strategy of diffusion causes shifts of transitivity structure which include dematerialization, expansion and the shift from mental into non-mental clause. When there is dematerialization, the clause type changes are:  (a) material clause of event to relational clause of identification; (b) material clause of event to relational clause of attributive; (c) material clause of event to relational clause of attributive with Attributor; (d) material clause of action to relational clause of attributive; (e) material clause of action to relational clause of attributive/possessive; and (f) material clause of action to relational clause of  identification. In the expansion, the nominalization construction turns into material clause, relational clause of attributive and mental clause of desiderative and cognitive. In the shift from mental into non-mental clause, mental clause of cognitive and desiderative becomes relational clause of attributive.
Ruang Andangan Arsitektur Limasan Sebagai Wadah Tradisi Kalang (Etnografi Demang Kalang (sub etnis Jawa)
Authors: Budi Prabani Setiohastorahmanto
Published: November 2018

Kelompok sub etnis Jawa,  hingga saat ini masih terus melaksanakan tradisi yang diwarisi oleh leluhur. Meskipun dianggap tradisi yang aneh oleh sebagian orang Jawa, namun masih terus dilaksanakan. Pelaksanaan tradisi tersebut merupakan implementasi dari filosofi tata ruang Jawa ruang gelap dan ruang terang. Tradisi tersebut dilaksanakan dalam wadah arsitektur tradisional Jawa Limasan. Sub etnis Jawa tersebut dikenal dengan nama Kalang, dalam penelitian ini disebut sebagai wong Kalang. Tradisi obong begitulah mereka menyebutnya, merupakan tanggung jawab keluarga terhadap anggota keluarga yang telah meninggal. Pertanyaan penelitian: 1) Apakah arsitektur Limasan memiliki hubungan dengan tradisi obong yang dilaksanakan wong Kalang?; 2) Apa makna arsitektur Limasan bagi kelompok wong Kalang? Penelitian ini akan mengungkap makna arsitektur Limasan bagi wong Kalang. Melalui teknik etnografi dengan menggunakan pendekatan penelitian kualitatif, akan ditemukan beberapa hubungan dan makna dari pelaksanaan tradisi Kalang dalam ruang arsitektur Limasan. Dari hasil penelitian dapat disimpulkan bahwa: 1) Setting ruang arsitektur Limasan memiliki hubungan dengan tradisi Kalang; 2) Arsitektur Limasan, memiliki makna yang penting dalam terlaksananya tradisi Kalang secara keseluruhan bukan hanya tradisi obong.Kata kunci: Kalang, Limasan, obong.
Mário Cláudio e o estilo biográfico / Mário Cláudio and the Biographical Style
Authors: Luís Carla Sofia Gomes Xavier
Published: November 2018

Resumo: Mário Cláudio tem vindo, ao longo dos 50 anos que se comemoram em 2019, desde a publicação, em 1969, de Ciclo de Cypris, a cultivaruma escrita coerente, com linhas de continuidade assinaláveis, de resto, como é apanágio de escritores de elevada qualidade estética.Partindo da sua última obra dada à estampa até então,Memórias Secretas (abril de 2018), onde podemos, desde logo, apreciar a continuidade da tendência à redação de biografias ficcionais, procuramos, com o presente trabalho, cumprir, dentro do possível, até pelas naturais restrições de espaço, odesiderato de perceber como funciona esta apetênciaao estilo biográfico, não deixando de trazer à colaçãooutros aspetos estilísticos bastanterecorrentes,bem como algumas temáticas eletivas mais marcantes na sua vasta, premiada e altamente qualificada obra.Palavras-chave: Mário Cláudio; estilo; biográfico; continuidade.Abstract: Mário Cláudio, during the past 50 years that will be celebrated in 2019, since the publication of Ciclo de Cyprisin 1969, has been cultivating a coherent writing, with notes of continuity that are remarkable, by the way, as all the high aesthetic quality writers. Starting from his last work, issued until the present times, Memórias Secretas (April 2018), where we can see the continuity of the tendency to fictional biographies writing, we try, with the present work, to fulfil, as far as possible, because of the natural restrictions of space, the purpose of perceiving how does it works this tendency to the biographical style, having in mind other relevant stylistic aspects, as well as some outstanding elective themes in its huge, awarded and highly qualified work.Keywords: Mário Cláudio; style; biographical; continuity.
La Ciencia economica y los procesos de desarollo - la experiencia cubana
Authors: Soto Olga Pérez
Published: November 2018

Este artigo aborda el desarrollo como  proceso multidimensional y multicausal desde condiciones de subdesarrollo. Es por eso que se asume la identidad del crecimiento  en función del desarrollo socialista como propuesta metodológica en la evolución de la noción del desarrollo que implica ruptura con la lógica del capital. Es en esa plataforma donde la política social es punto de partida y llegada complejo de los procesos y de las políticas para el desarrollo en la complejidad de sus interrelaciones. Se concluye con los aspectos más relevantes  de la experiencia de desarrollo  en Cuba
Crise capitalista e reconfiguração das políticas sociais
Authors: Ferraz Ana Targina Rodrigues , Mendonça Luiz Jorge Vasconcellos Pessoa de
Published: November 2018

É inegável que, atualmente, as políticas sociais contam com uma notoriedade e importância crescente para o conjunto da sociedade. No entanto, os motivos para tal consideração nem sempre estão claros. Para alguns, atingiu-se enfim um desenvolvimento quantitativo e qualitativo de práticas compatíveis com as necessidades de enfrentamento da pobreza e superação das desigualdades inerentes ao processo de acumulação capitalista. Tratar-se-ia de um resgate necessário em benefício de amplos segmentos da sociedade, em especial nos países da periferia. Para outros, o desenvolvimento observado no âmbito da formulação, implantação e acompanhamento das políticas sociais seguiria as novas exigências impostas pela reconfiguração do processo de produção e do mercado mundial. A redefinição do papel do Estado, as novas organizações sociais, de direito público e privado, e o redimensionamento das relações e estruturas políticas de poder explicariam também a reformulação, a atualização e a multiplicação das formas de intervenção social.
Trabalho Extrativista e condições de vida dos trabalhadores/famílias na Ilha Combú-Pará
Authors: Gomes Vera Lúcia Batista , Carvalho Raimundo Sócrates de Castro
Published: November 2018

Este artigo analisa o trabalho extrativista do açaí na ilha do Combú-Pará e as condições de vida dos trabalhadores. Tem como base a pesquisa de campo cujos sujeitos foram trabalhadores que exercem esse trabalho na referida ilha. Parte da reflexão sobre o trabalho extrativista e o modelo de desenvolvimento imposto para a Amazônia, o qual responde aos interesses do capital em versão globalizada, reeditando a sua inserção na divisão internacional do trabalho, via reprimarização da economia. Esse modelo determina as formas de trabalho precário e as condições de vida dos trabalhadores/famílias que dependem do trabalho para a reprodução social. Ao final, destaca que a renda obtida com esse trabalho e a precariedade dos serviços públicos de saúde, educação, saneamento básico atendem minimamente as necessidade imediatas dos mesmos, mas contraditoriamente, aumenta a comercialização do açaí.
Política social, família e gênero: Temas em discussão
Authors: Freitas Rita de Cássia Santos , Braga Cenira Duarte , Barros Nívia Valença
Published: November 2018

Este artigo tem como objetivo refletir acerca da relação entre políticas sociais no contexto atual e famílias pobres brasileiras – local onde as mulheres, por conta das relações de gênero, aparecem como as principais protagonistas. Essa análise se faz necessária na medida em que a matricialidade sociofamiliar nas políticas sociais trazem de volta a discussão sobre a família. No Brasil, essa é uma realidade que tem colocado em situação de vulnerabilidade um grande número de famílias. Pretendemos refletir, nesse espaço, as relações entre política social, famílias e as relações de gênero.
Necessidades do capital versus necessidades humanas no capitalismo contemporâneo: uma competição desigual
Authors: Gomes Junior Newton N. , Pereira Potyara A. P.
Published: November 2018

Este ensaio inscreve-se no circuito das análises que destacam a postura contraditória da política social perante dois conjuntos antagônicos de necessidades: as humanas e as do capital. No atual cenário de expansão galopante das necessidades de lucro do capital, em que fortes contenciosos se confrontam em torno de bens, serviços e direitos de natureza pública, os autores refletem sobre as implicações desse processo para a satisfação das necessidades humanas, argumentando que: sob a supremacia do mercado, preferências individuais se sobrepõem às noções de necessidades coletivas, trocando-se direitos sociais pela meritocracia. Por fim, esclarecem que não têm intenção de apontar saídas, mas somente alertar para uma situação que anuncia tragédias.
Aspectos epistemológicos subjacentes a erros individuais frequentes no ensino institucionalizado
Authors: Miranda Werventon Dos Santos , Farias Luciana de Nazaré , Pereira Filho Silvio Carlos Ferreira
Published: November 2018

Neste artigo procuramos discutir as questões epistemológicas que estão presentes nas causas dos erros individuais no processo de ensino e aprendizagem das disciplinas escolares, mais precisamente relacionados aos conhecimentos da Matemática, Física e Biologia; procuramos trazer inicialmente uma noção histórica e conceitual dos principais termos que envolvem essa temática como erro e epistemologia; buscamos evidenciar a luz de Bachelard e Vygotsky, além de outros que trazem questões especificas nas Ciências  em destaques os elementos que subjazem os erros que manifestamos na caminhada escolar; e finalizamos expressando, nas considerações finais, nossa visão do erro como ferramenta da ação pedagógica para contribuir com os alunos na perspectiva de superação a fim de que o objetivo do processo educativo seja alcançado – a aprendizagem.
A cross-sectional study of female sexual dysfunction among Turkish pregnant and nonpregnant women: correlation with hormone profile
Authors: SARIİBRAHİM ASTEPE Bahar , KÖLELİ İşıl
Published: November 2018

Objectives:
To determine the
prevalence of female sexual dysfunction (FSD) and its correlation with the
androgenic hormones among pregnant and nonpregnant Turkish women. Methods: This was a cross-sectional study
of 251 women, including 137 healthy pregnant and 114 healthy nonpregnant
Turkish women. Assessment of female sexual function index (FSFI), sociodemographic
characteristics, serum androgen levels, including the total testosterone,
dehydroepiandrosterone sulfate (DHEAS), 1-4 delta androstenedione. Results: There was a 65.7 % incidence of
FSD in all of the participants, with an incidence of 58.8% in the pregnant and
41.2% in the nonpregnant women. There
was no significant difference in the FSFI total scores between the pregnant and
nonpregnant women (p > 0.05).
Moreover, the androgen levels were not different
between the women with sexual dysfunction and those without. The Spearman
correlation test results were significant between the total testosterone level and
the FSFI arousal domain (r=0.167, p <
0.05), FSFI lubrication domain (r=0.264, p
< 0.01), and FSFI total score (r=0.212, p
< 0.01)., as well as between the androstenedione level and FSFI lubrication
domain (r=0.211, p < 0.01), FSFI
orgasm domain (r=0.156, p < 0.05),
and FSFI total score (r=0.174, p <
0.05). In the logistic regression analysis for sexual dysfunction, an increase in the DHEAS level increased the
sexual dysfunction by 0.996-fold. Women with one pregnancy had 3.312-fold
greater sexual dysfunction than those with no pregnancies. Moreover, the women
with more than eight years of education had 0.358 times more sexual dysfunction
than those with eight years of education and less.

Conclusion: The FSFI total scores were not significantly
different between the pregnant and nonpregnant women. However, there were
significant correlations between the total testosterone and androstenedione
levels and the FSFI total scores. Any increases in the DHEAS level and
educational level in women decrease the chance of developing sexual
dysfunction.
Spatial Variation in Size and Shape of Land Plots in Mazowieckie Voivodship
Authors: Borowska-Stefańska Marta , Leśniewska-Napierała Katarzyna , Wiśniewski Szymon
Published: November 2018

The aim of the study is to evaluate the spatial variation in the size and shape of land plots in Mazowieckie voivodship. For the purposes of the study both the shape and the compactness of the plots were measured, and the typology of communes was drawn based on this information. Subsequently, based on the two indicators related to the shape of plots, four types of communes were distinguished, depending on whether their values were higher or lower than the average (Dzieciucho­wicz and Dmochowska-Dudek, 2014). In addition, the paper includes calculations for the average share of unused land in the plot surface area, the average horizontal intensity of parcel development, and an indication of the type of land coverage dominant in the plots, by commune type. Pearson’s correlation coefficient was used in the analyses. It has been found that the studied area is dominated by plots characterised by small diversity in shape and high degree of compactness – mainly in the north-western part of the voivodship, as well as those where plots are highly diverse in shape and low in compactness – in the south-eastern part of the voivodship.
Residential Segregation in Warsaw and its Metropolitan Area in the Context of Changing Housing Policy
Authors: Grzegorczyk Anna , Jaczewska Barbara
Published: November 2018

Warsaw and its metropolitan area seem an interesting testing ground for research on the phenomenon of residential segregation in the context of the evolution of housing policy, since the city has been subject to significant changes as a result of historical events. Each of these contributed to alterations in the level and the character of residential segregation. The goal of this article is to answer the following question: Was the changing housing policy in Warsaw and the surrounding metropolitan area during the transformation period and afterwards accompanied by a modification of the segregation structure and what differences can be noticed in the whole of the metropolitan area and in the city itself?
Shakespeare, Authority and Hauntology: Postdramatic Performance in Walny Theatre’s Hamlet
Authors: Lorek-Jezińska Edyta
Published: November 2018

The aim of this article is to explore the potential of hauntological theories to explain and problematise selected aspects of authority and performance in the context of Shakespeare’s drama. Referring primarily to Derrida’s and Abraham’s concepts of the ghost and the phantom and their connection to Shakespeare’s Hamlet, the article discusses hauntological perspectives on performance, both deconstructing and reaffirming authority. The paper comments on the relation between text and performance (Brook, Lehmann), memory and repetition (Carlson), disappearance and perpetual present (Phelan), as well as archive and repertoire (Taylor) in order to highlight the contradictory yet productive ways of understanding performance. The final part of the article, focusing on the significance of the ghost figure, examines experimental appropriations of Shakespeare’s play in Walny Theatre’s Hamlet (2015) in the light of postdramatic aesthetics.
Soluções integrando BIM e Internet das Coisas no ciclo de vida da edificação: uma revisão crítica
Authors: Machado Fernanda Almeida , Ruschel Regina Coeli
Published: November 2018

O objetivo deste artigo é identificar, analisar e estratificar em classes de problemas os componentes, modelos e métodos das soluções existentes na literatura que integram Modelagem da Informação da Construção (BIM) e Internet das Coisas (IoT). Foram adotados os procedimentos metodológicos da Revisão Sistemática da Literatura (RSL) para o mapeamento de estudos convergentes, a identificação de artefatos já produzidos inerentes à integração mencionada e a configuração de classes de problemas. Os resultados constatam artefatos concentrados majoritariamente na fase de Operação e Manutenção da edificação e interesse crescente na fase de Construção e Comissionamento; maior recorrência de modelos e instanciações na integração de BIM e IoT, que atende a nove classes de problemas distintos e apresenta-se em pleno desenvolvimento. São discriminados as séries e os usos do modelo BIM empregados em cada contexto, bem como as tecnologias utilizadas. Ademais, são evidenciados os propósitos do BIM e da IoT na integração e os principais agentes envolvidos no processo. Apontam-se novos campos de pesquisa em um estágio post-BIM, nos quais a modelagem da informação da construção transcende para um contexto multidisciplinar, abarcando soluções específicas de Tecnologias da Informação e Comunicação (TIC) e Sensoriamento que devem ampliar as relações estáticas ou dinâmicas entre os ambientes físico e virtual.
Piso misto de pequena altura: componentes e processo construtivo
Authors: Kochem Raimundo Fagner Freitas , De Nardin Silvana
Published: November 2018

A procura por sistemas construtivos mais eficientes vem crescendo gradualmente nos últimos anos no Brasil. Neste cenário está inserido o sistema misto de aço e concreto que apresenta grandes vantagens tanto estruturais como construtivas. O piso misto de pequena altura trata-se da associação entre viga mista e laje mista, cuja principal característica é o embutimento da viga na laje; tal embutimento proporciona redução da altura total do sistema laje-viga aumentando o pé-direito do pavimento. Por ser um sistema em que grande parte dos elementos é industrializado, o piso misto de pequena altura permite diversas combinações entre vigas e lajes, sempre mantendo sua principal característica que é o embutimento total ou parcial da laje na viga. Assim, tomando o piso misto de pequena altura como objeto de estudo, o presente artigo apresenta as principais características desse sistema, descreve os principais componentes, dando destaque aos componentes pré-fabricados, às técnicas inerentes ao processo construtivo, incluindo equipamentos necessários à execução e detalhes construtivos. Isto é feito para quatro configurações de piso misto de pequena altura: perfil Deltabeamâ e laje mista; perfil Deltabeamâ e laje pré-fabricada de concreto, perfil I assimétrico de aço associado a laje mista e perfil I assimétrico e laje pré-fabricada de concreto.
Desenvolvimento do acervo informacional do IFBA na ótica dos responsáveis pelas unidades informacionais
Authors: Almeida Bonifácio Chaves de , Machado Raymundo das Neves
Published: November 2018

Com o objetivo de investigar a percepção dos responsáveis pelas unidades informacionais dos campi do Instituto Federal de Educação, Ciência e Tecnologia da Bahia (IFBA), no que tange aos procedimentos para a formação e desenvolvimento da coleção de material informacional da autarquia e a comparação dessa percepção com os preceitos da literatura da área, foi realizada uma pesquisa com a população de representantes das unidades informacionais da instituição, metodologicamente caracterizada como exploratória no que tange aos objetivos, quantitativa no que se refere à abordagem do problema e de levantamento ou survey, quanto aos procedimentos. De início, conjecturou-se que, na visão dos representantes dessas unidades informacionais, as bases teóricas acerca do tema eram empregadas com parcimônia e que não assentia a construção do acervo informacional colaborativo das unidades, apesar da estrutura multicampi do IFBA. Os resultados, alcançados a partir da análise de dados correlatos por meio da proposta de Macnaughton e do oscilador estocástico de Wilder Júnior, apontaram para algumas variáveis o emprego moderado, para outras o uso apresenta robusteza e em algumas variáveis a empregabilidade do ensinamento teórico-conceitual, quanto ao gerenciamento da coleção informacional, é frágil.
Ensino de probabilidade e estatística por meio da análise exploratória de dados e resolução de problemas
Authors: Souza Fabiano dos Santos
Published: November 2018

O presente artigo baseia-se em estudos, pesquisas e reflexões de um grupo de pesquisa de Ensino e Aprendizagem em Matemática e Estatística, os quais foram convertidos em uma proposta metodológica para o ensino de probabilidade e estatística implementada numa oficina ministrada no III Dia da Matemática do Laboratório de Educação Matemática (LABEM) de uma Universidade Federal. No estudo participaram 24 sujeitos do curso de licenciatura em Matemática, com objetivo de avaliar a proposta em relação ao processo de ensino e aprendizagem dos conteúdos básicos de estatística e probabilidade. Questões teóricas e metodológicas sobre o ensino de probabilidade e estatística foram discutidas, refletidas e trabalhadas durante a oficina, que foi organizada sob a perspectiva de Batanero (2001) e por meio da resolução de problemas Walle (2009). Os objetivos principais desta oficina foram: (i) identificar a Estatística como sendo uma poderosa ferramenta para análise de dados, que pode ser utilizada de forma a equilibrar técnicas e conceitos; (ii) proporcionar aos participantes um espaço de reflexão para a construção de um trabalho coletivo, que interligue saberes acadêmicos e práticos. Os resultados deste trabalho constataram que o ensino de probabilidade e estatística quando é realizado por meio da metodologia da resolução de problemas e da análise exploratória de dados, torna-se mais significativa, fazendo com que os conhecimentos adquiridos nesse processo estejam conectados com o cotidiano dos alunos e com os seus respectivos conhecimentos prévios, proporcionando a construção do letramento estatístico.
Metagenomic Characterization of the Viral Community of the South Scotia Ridge
Authors: Yang Qingwei , Gao Chen , Yong Jiang , Wang Ming , Zhou Xinhao , Shao Hongbing , Gong Zheng , McMinn Andrew
Published: November 2018

Viruses are the most abundant biological entities in aquatic ecosystems and harbor an enormous genetic diversity. While their great influence on the marine ecosystems is widely acknowledged, current information about their diversity remains scarce. A viral metagenomic analysis of three water samples was conducted from sites on the South Scotia Ridge (SSR) near the Antarctic Peninsula, during the austral summer 2016. The taxonomic composition and diversity of the viral communities were investigated and a functional assessment of the sequences was determined. Phylotypic analysis showed that most viruses belonging to the order Caudovirales, especially the family Podoviridae (41.92-48.7%), similar to the viromes from the Pacific Ocean. Functional analysis revealed a relatively high frequency of phage-associated and metabolism genes. Phylogenetic analyses of phage TerL and Capsid_NCLDV (nucleocytoplasmic large DNA viruses) marker genes indicated that many sequences associated with Caudovirales and NCLDV were novel and distinct from known phage genomes. High Phaeocystis globosa virus virophage (Pgvv) signatures were found in SSR area and complete and partial Pgvv-like were obtained which may have an influence on host-virus interactions. Our study expands the existing knowledge of viral communities and their diversities from the Antarctic region and provides basic data for further exploring polar microbiomes.
Sex Differences in Context-Driven Reinstatement of Methamphetamine Seeking Is Associated with Distinct Neuroadaptations in the Dentate Gyrus
Authors: Takashima Yoshio , Tseng Joyee , Fannon McKenzie J. , Purohit Dvijen C. , Quach Leon W. , Terranova Michael J. , Kharidia Khush M. , Oliver Robert J. , Mandyam Chitra D.
Published: November 2018

The present study examined differences in operant responses in adult male and female rats during distinct phases of addiction. Males and females demonstrated escalation in methamphetamine (0.05 mg/kg, i.v.) intake with females showing enhanced latency to escalate, and bingeing. Following protracted abstinence, females show reduced responses during extinction, and have greater latency to extinguish compared with males, indicating reduced craving. Females demonstrated lower context-driven reinstatement compared to males, indicating that females have less motivational significance to the context associated with methamphetamine. Whole-cell patch-clamp recordings on dentate gyrus (DG) granule cell neurons (GCNs) were performed in acute brain slices from controls and methamphetamine experienced male and female rats and neuronal excitability were evaluated from GCNs. Reinstatement of methamphetamine seeking reduced spiking in males, and increased spiking in females compared to controls, demonstrating distinct neuroadaptations in intrinsic excitability of GCNs in males and females. Reduced excitability of GCNs in males were associated with enhanced levels of neural progenitor cells, expression of plasticity-related proteins including CaMKII and choline acetyltransferase in the DG. Enhanced excitability in females were associated with increased GluN2A/2B ratio, indicating changes in postsynaptic GluN subunit composition in the DG.  Altered intrinsic excitability of GCNs were associated with reduced mossy fiber terminals in the hilus and pyramidal projections, demonstrating compromised neuroplasticity in the DG in both sexes. The alterations in excitability, plasticity-related proteins and mossy fiber density were correlated with enhanced activation of microglial cells in the hilus, indicating neuroimmune responses in both sexes. Together, the present results indicate sexually dimorphic adaptive biochemical changes in excitatory neurotransmitter systems in the DG and highlight the importance of including sex as a biological variable in exploring neuroplasticity and neuroimmune changes that predict enhanced relapse to methamphetamine-seeking behaviors.
Model Predictive Control for a Recover Water Process
Authors: Mercorelli Paolo
Published: November 2018

The goal of this contribution is an application of the Linear General Model Predictive Control (LGMPC). In this paper, stability of the LGMPC is proven by means of a demonstration of a Theorem stating a sufficient and constructive condition. This condition can be applied for calculating the weight matrices of the cost function in the optimisation problem in LGMPC. Lower bounds conditions are found for one of these matrices and then a system with saturation is taken into consideration. The conditions could be interpreted and discussions through physical aspects. The obtained results were tested by means of computer simulations and an example with a recover water process is considered.
Recent Progress in Surface Plasmon Resonance Biosensors  (2016 to Mid-2018)
Authors: Gorodkiewicz Ewa , Lukaszewski Zenon
Published: November 2018

Almost 50 papers on surface plasmon resonance biosensors, published between 2016 and mid-2018, are reviewed. Papers concerning the determination of large particles such as vesicles, exosomes, cancer cells, living cells, stem cells and microRNA are excluded, as these are covered by a very recent review. The reviewed papers are categorized into five groups, depending on the degree of maturity of the reported solution: ranging from simple marker detection to clinical application of a previously developed biosensor. Instrumental solutions and details of biosensor construction are analyzed, including the chips, receptors and linkers used, as well as calibration strategies. Biosensors with a sandwich structure containing different nanoparticles are considered separately, as are SPR applications for investigating the interactions of biomolecules. An analysis is also made of the markers determined using the biosensors. Concluding, there is shown to be a growing number of SPR applications in the solution of real clinical problems.
Finite Element Analysis of Adolescent Mandible Fracture Occurring during Accidents
Authors: Żmudzki Jarosław , Panek Karolina , Chladek Grzegorz , Adamiak Marcin , Lipinski Paul
Published: November 2018

The paper aims in assessing risks of mandible fractures consequent to impacts or sport accidents. The role of the structural stiffness of mandible, related to disocclusion state, is evaluated through numerical simulations using the finite element method (FEM). It has been assumed that the quasi-static stress field, due to distributed forces developed during accidents, could explain the common types of mandibular fractures. Geometric model of adolescent mandible was built, upon the basis of medical imaging, in CAD software with distinction between cortical layer and inner spongy bone. The finite element model of disoccluded mandible was next created. Mandibular condyles were supposed jammed in the maxillary fossae. The total force of 700 N, simulating an impact on mandible, has been sequentially applied in three distinct areas: centrally, at canine zone and at the mandibular angle. Clinically most frequent fractures of mandible were recognized through the analysis of maximal principal stress and maximal principal strain fields. Mandibular fracture during accidents can be analyzed at satisfactory level using linear quasi-static FE models for designing protections in sport and transport. The proposed approach can be improved by introducing more realistic interactions between condylar processes and fossae.
Unstructured Text in EMR Improves Prediction of Death after Surgery in Children
Authors: Akbilgic Oguz , Homayouni Ramin , Heinrich Kevin , langham, Jr Max Raymond , Davis Robert Lowell
Published: November 2018

Text fields in electronic medical records (EMR) contain information on important factors that influence health outcomes, however, they are underutilized in clinical decision making due to their unstructured nature. We analyzed 6,497 inpatient surgical cases with 719,308 free text notes from Le Bonheur Children’s Hospital EMR. We used a text mining approach on preoperative notes to obtain the text-based risk score algorithm as predictive of death within 30 days of surgery. We studied the additional performance obtained by including text-based risk score as a predictor of death along with other structured data based clinical risk factors. The C-statistic of a logistic regression model with 5-fold cross-validation significantly improved from 0.76 to 0.92 when text-based risk scores were included in addition to structured data. We conclude that preoperative free text notes in EMR include significant information that can predict adverse surgery outcomes.
The Relevance of Foreshocks in Earthquake Triggering: A Statistical Study
Authors: Lippiello Eugenio , Godano Cataldo , De Arcangelis Lucilla
Published: November 2018

An increase of seismic activity is often observed before large earthquakes. Events responsible for this increase are usually named foreshock and their occurrence probably represents the most reliable precursory pattern. Many foreshocks statistical features can be interpreted in terms of the standard mainshock-to-aftershock triggering process and are recovered in the Epidemic Type Aftershock Sequence ETAS model. Here we present a statistical study of instrumental seismic catalogs from four different geographic regions. We focus on some common features of foreshocks in the four catalogs which cannot be reproduced by the ETAS model. In particular we find in instrumental catalogs a significantly larger number of foreshocks than the one predicted by the ETAS model. We show that this foreshock excess cannot be attributed to catalog incompleteness. We therefore propose a generalized formulation of the ETAS model, the ETAFS model, which explicitly includes foreshock occurrence. Statistical features of aftershocks and foreshocks in the ETAFS model are in very good agreement with instrumental results.
Maize Canopy Photosynthesis, Plant Growth, and Yield Responses to Tillage Depth
Authors: Sun Jiying , Gao Julin , Wang Zhigang , Hu Shuping , Zhang Fengjie , Bao Haizhu , Fan Yafang
Published: November 2018

Subsoil tillage loosens compacted soil for better plant growth, but promotes water loss, which is a concern in areas commonly irrigated. Therefore, our objective was to determine the physiological responses of high yield spring corn (Zea mays L.) to Subsoil tillage depth when grown in the western plain irrigation area of Inner Mongolia that leads to the best water use efficiency. The experiment during 2014 and 2015 used Zhengdan958 and Xianyu335 with three differing subsoil tillage depths (30, 40, or 50 cm) as trial factor and shallow rotary as a control. Subsoil tillage increased shoot dry matter accumulation, leading to a greater shoot/root ratio. Subsoil tillage helped retain greater leaf area index in each growth stage, increase the leaf area duration, net assimilation rate, and relative growth rate, with greater effects as tillage was deeper, effectively delaying the aging of the blade. Grain yields were increased by 0.7%–8.9% on average in subsoil tillage treatments compared to conventional soil treatment shallow rotary, Water use efficiency were increased by 1.93%–18.49% on average in subsoil tillage treatment compared to shallow rotary, resulting in net income increases by 2.24% to 6.97% compared to shallow rotary. Among the three different subsoil tillage depth treatment, the grain yield, water use efficiency, and net income is the best under the treatment of subsoil tillage depth of 50 cm.
Macrophages from Mice Administered Rhus Verniciflua Stokes Extract Show Selective Anti-Inflammatory Activity
Authors: Kim Bo-Geun , Song Youngju , Lee Mi-Gi , Gu Jin-Mo , Lee SeungGwan , Kang Hee
Published: November 2018

The bark of Rhus verniciflua Stokes (RVS) is used as a food additive and herbal medicine for various inflammatory disorders and cancer in Eastern Asia. RVS exerted anti-inflammatory effects in lipopolysaccharide (LPS)-stimulated RAW264.7 cells, but whether this effect occurs in macrophages after oral administration has not been determined. We used a thioglycollate-induced peritonitis model to obtain macrophages from mice given RVS. We examined the systemic inflammatory response to intraperitoneal LPS. RVS-treated mice had an increased population of peritoneal exudate cells expressing CD11b and SRA. Increased uptake of Alexa Fluor 488-labeled acetylated lipoprotein was observed in monocyte-derived macrophages from RVS-treated mice. When these cells from the RVS group were stimulated with LPS, the levels of tumor necrosis factor (TNF)- and interleukin (IL)-6 in the supernatant decreased, but the level of IL-12 increased. The surface expression of CD86 was reduced, but surface expression of class II MHC molecules was increased. RVS suppressed the serum levels of LPS-induced TNF- and IL-6. RVS enhanced monocyte differentiation in thioglycollate-induced peritonitis by increasing scavenger receptor expression and activity. Macrophages isolated from mice given RVS responded differently to LPS. These findings demonstrate that RVS confers selective anti-inflammatory activity without causing the overall inhibitory effects on immune cells.
Sii-Mobility: an IOT/IOE Architecture to Enhance Smart City Services of Mobility and Transportation
Authors: Nesi Paolo , Badii Cladio , Difino Angelo
Published: November 2018

The new IoT/IoE (internet of things/everythings) paradigm and architecture permits to rethink about the way the Smart City infrastructures are designed and managed, on the other hand a number of problems have to be solved. In terms of mobility the cities that embrace the sensoring era can take advantage of this disruptive technology to improve the quality of life of their citizen, also thanks the rationalization in the use of their resources. In Sii-Mobility, a national smart city project on mobility and transportation, a flexible platform has been designed and here, in this paper, is presented. It permits to setup heterogeneous and complex scenarios that integrate sensors/actuators as IoT/IoE in an overall scenario of Big Data, Machine Learning and Data Analytics. A detailed and complex case-study has been presented to validate the solution in the context of a system that dynamically reverse the traveling direction of a road segment, with all the safety conditions in place. This case study composes several building blocks of the IoT platform, which demonstrate that a flexible and dynamic set-up is possible, supporting off-grid, security, safety, cloud and mixed solutions.
Augmentation of 5-aminolevulinic Acid Treatment of Glioblastoma by Adding Ciprofloxacin, Deferiprone, 5-fluorouracil and Febuxostat: The CAALA Regimen
Authors: Kast Richard , Skuli Nicolas , Sardi Iacopo , Capanni Felix , Hessling Martin , Frosina Guido , Kast Anton , Karpel-Massler Georg , Halatsch Marc-Eric
Published: November 2018

The CAALA (Complex Augmentation of ALA) regimen was developed with the goal of redressing some of the weaknesses of 5-aminolevulinic acid (5-ALA) use in glioblastoma treatment as it now stands. 5-ALA is approved for use prior to glioblastoma surgery to better demarcate tumor from brain tissue. 5-ALA is also used in intraoperative photodynamic treatment of glioblastoma by virtue of uptake of 5-ALA and its selective conversion to protoporphyrin IX in glioblastoma cells. Protoporphyrin IX becomes cytotoxic after exposure to 410 nm or 635 nm light. CAALA uses four currently marketed drugs - the antibiotic ciprofloxacin, the iron chelator deferiprone, the antimetabolite 5-FU, and the xanthine oxidase inhibitor febuxostat - that all have evidence of ability to both increase 5-ALA mediated intraoperative glioblastoma demarcation and photodynamic cytotoxicity of in situ glioblastoma cells. Data from testing the full CAALA on living minipigs xenotransplanted with human glioblastoma cells will determine safety and potential for benefit in advancing CAALA to a clinical trial.
Car Soundproof Improvement Through an SMA Adaptive System
Authors: Ameduri Salvatore , Brindisi Angela , Ciminello Monica , Concilio Antonio , Quaranta Vincenzo , Brandizzi Marco
Published: November 2018

The work at hand focuses on an adaptive system aimed at improving the soundproof performance of car door seals at specific working regimes (cruise), without interfering with the conventional open-closure operations. The idea addresses the necessity of increasing the seal effectiveness, jeopardized by aerodynamic actions more and more important as the speed increase, generating a pressure difference between the internal and the external filed, in the direction of opening the door. To recover this effect, an expanding mechanism was integrated within the seal cavity, driven by an SMA actuator. The material was activated (heated) by Joule effect; its compactness, intrinsic of smart materials, contributed to arrive to a final system characterized by a high level of integrability (expanding cells). In this paper, the development process is described together with the verification activity, aimed at proving the functionality of the realized device. Starting from the industrial requirements, the most appropriate solution was identified highlighting the working principle and the main design parameters involved. Then, the envisaged system was designed and its executive digital mock up (CAD) was released. Prototyping and laboratory validation showed the reliability of the numerical models and the associated predictions. On this basis, the integration task within the actual reference car was faced. To demonstrate the isolation effect of the proposed system, an experimental campaign was finally organized in an anechoic room, achieving significant results on the concept value.
Targeting Adenosine Receptor Signaling in Cancer Immunotherapy
Authors: Sek Kevin , Mølck Christina , Stewart Gregory D. , Kats Lev , Darcy Phillip K. , Beavis Paul A.
Published: November 2018

The immune system plays a major role in the surveillance and control of malignant cells, with the presence of tumor infiltrating lymphocytes (TILs) correlating with better patient prognosis in multiple tumor types. The development of ‘checkpoint blockade’ and adoptive cellular therapy has revolutionized the landscape of cancer treatment and highlights the potential of utilizing the patient’s own immune system to eradicate cancer. One mechanism of tumor-mediated immunosuppression that has gained attention as a potential therapeutic target is the purinergic signaling axis, whereby the production of the purine nucleoside adenosine in the tumor microenvironment can potently suppress T and NK cell function. The production of extracellular adenosine is mediated by the cell surface ectoenzymes CD73, CD39 and CD38 and therapeutic agents have been developed to target these as well as the downstream adenosine receptors (A1R, A2AR, A2BR, A3R) to enhance anti-tumor immune responses. This review will discuss the role of adenosine and adenosine receptor signaling in tumor and immune cells with a focus on their cell-specific function and their potential as targets in cancer immunotherapy.
Overview of Genomic Tools for Circular Visualization in next-Generation Genomic Sequencing Era
Authors: Parveen Alisha , Khurana Sukank , Kumar Abhishek
Published: November 2018

After human genome sequencing and rapid changes in genome sequencing methods, we have entered in the era of rapidly accumulating genome-sequencing data. This has poses development of several types of methods for representing results of genome sequencing data. Circular genome visualizations tools are also critical in this area as they provide rapid interpretation and simple visualization of overall data. In the last 15 years, we have seen rapid changes in circular visualization tools after the development of the circos tool with 1–2 tools published per year. Herein we have summarized and revisited all these tools until the third quarter of 2018. 
GÊNESE DA EDUCAÇÃO AMBIENTAL EM JOHN DEWEY E EM PAULO FREIRE E AS PERSPECTIVAS ATUAIS: O QUE HÁ DE NOVO?
Authors: Modesto Monica Andrade , Nepomuceno Aline Lima de Oliveira , Araujo Maria Inêz Oliveira
Published: November 2018

Pensar a problemática socioambiental tornou-se tarefa imprescindível da educação. Nesse sentido, muitas são as perspectivas que circundam a educação ambiental nos dias atuais, embasadas em uma pluralidade de pensamentos e tendências, todavia, nota-se um despontamento para o enfoque eco-sistêmico educacional. Em que pese sejam tidas como novas, muitas ideias difundidas na atualidade têm suas premissas fundadas na Filosofia da Educação, ainda que de forma velada. Sendo assim, este artigo objetiva refletir os elementos presentes nos pensamentos de John Dewey e de Paulo Freire que podem ser considerados como prenunciadores da gênese da educação ambiental crítica a partir de um estudo comparativo. Estruturado em tópicos analíticos acerca da relação ambiente e educação no âmbito da Modernidade e da Pós-Modernidade, bem como no âmbito das obras dos autores mencionados e das perspectivas atuais, o estudo aponta que as teorias emergentes do século XXI não são inéditas, mas adjeções de reflexões que vêm sendo discutidas ao longo dos tempos.
TEORIA EDUCACIONAL NA PESQUISA EM EDUCAÇÃO: UMA APRESENTAÇÃO
Authors: Sobral Maria Neide
Published: November 2018

Apresentação da seção temática.
Potential Impact of HIV Preexposure Prophylaxis Among Black and White Adolescent Sexual Minority Males
Authors: Hamilton Deven T. , Goodreau Steven M. , Jenness Samuel M. , Sullivan Patrick S. , Wang Li Yan , Dunville Richard L. , Barrios Lisa C. , Rosenberg Eli S.
Published: November 2018

Objectives. To assess the potential impact of preexposure prophylaxis (PrEP) on the HIV epidemic among Black and White adolescent sexual minority males (ASMM).

Methods. We used a network model and race-specific data from recent trials to simulate HIV transmission among a population of Black and White 13- to 18-year-old ASMM over 20 years. We estimated the number of infections prevented (impact) and the number needed to treat to prevent an infection (efficiency) under multiple coverage and adherence scenarios.

Results. At modeled coverage and adherence, PrEP could avert 3% to 20% of infections among Black ASMM and 8% to 51% among White ASMM. A larger number, but smaller percentage, of infections were prevented in Black ASMM in all scenarios examined. PrEP was more efficient among Black ASMM (number needed to treat to avert an infection = 25–32) compared with White ASMM (146–237).

Conclusions. PrEP can reduce HIV incidence among both Black and White ASMM but is far more efficient for Black ASMM because of higher incidence.

Public Health Implications. Black ASMM communities suffer disproportionate HIV burden; despite imperfect adherence, PrEP programs could prevent HIV efficiently in these communities.