bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengaruh Agen Kimia Berbeza terhadap Penguraian Terma dan Pembentukan Fasa Bahan La0.6SR0.4CoO3- δ yang Disediakan melalui Kaedah Sol-Gel
Authors: Abdul Samat Abdullah , Somalu Mahendra Rao , Muchtar Andanastuti , Abd. Rahman Hamimah , Osman Nafisah
Published: December 2020

Sifat penguraian terma dan pembentukan fasa bahan lantanum strontium kobalt oksida, La0.6Sr0.4CoO3-δ (LSC) yang disediakan melalui kaedah sol-gel berbantu agen kimia berbeza, iaitu agen serakan, agen pempolimeran dan agen permukaan aktif atau surfaktan telah dicirikan secara sistematik masing-masing melalui analisis termogravimetrik (TG) dan pembelauan sinar-X (XRD). Penguraian terma bahan organik dan bahan bukan organik yang tidak diperlukan dalam serbuk pelopor bahan LSC telah lengkap pada suhu kurang daripada 1000 °C bagi serbuk pelopor yang disediakan dengan menggunakan agen serakan dan agen pempolimeran, dan suhu melebihi 1000 °C bagi serbuk pelopor yang disediakan dengan menggunakan surfaktan. Sifat penguraian terma ini dipengaruhi oleh suhu pengeringan serbuk pelopor tersebut dan berat molekul agen kimia. Pembentukan fasa tunggal perovskit LSC telah disahkan dalam serbuk pelopor yang disediakan dengan menggunakan agen serakan, iaitu karbon teraktif dan agen pempolimeran, iaitu etilena glikol selepas serbuk pelopor tersebut dikalsin pada suhu 900 °C. Sebaliknya, fasa tunggal perovskit LSC tidak terbentuk secara lengkap dalam serbuk pelopor yang disediakan dengan menggunakan surfaktan (polietilena glikol, Triton-X-100, Brij-97 dan Tween-80) walaupun selepas serbuk pelopor tersebut telah dikalsin pada suhu yang lebih tinggi iaitu 1100 °C. Kepekatan surfaktan, nisbah molar surfaktan kepada logam kation dan nilai pH larutan bahan pelopor yang tidak sesuai telah menyumbang kepada keputusan tersebut.
Diagnostic utility of exome sequencing for inherited peripheral neuropathies
Authors: Shchagina O. A. , Ryzhkova O. P. , Chukhrova A. L. , Milovidova T. V. , Gundorova P. , Mironovich O. L. , Orlova A. A. , Orlova M. D. , Poliakov A. V.
Published: December 2020

Introduction. Hereditary motor and sensory neuropathies, a highly genetic heterogeneous group of disorders, have a phenotype caused by peripheral nerve damage.

Purpose of the study – to assess the extent of genetic heterogeneity of hereditary motor and sensory neuropathies in Russian patients and to evaluate the diagnostic effectiveness of using full-exome research methods to find the genetic cause of hereditary motor and sensory neuropathies.

Materials and methods. The material for the study was DNA samples from 51 patients and their family members referred for whole exome sequencing to the DNA-diagnostics laboratory of Research Centre for Medical Genetics in 2017–2019. Methods: whole exome sequencing, Sanger sequencing, restriction fragment length polymorphism.

Results. Whole exome sequencing in combination with segregation analysis of the pathogenic variants in families allowed to determine the cause of the disease in 41 % of cases. In another 16 % of cases, candidate genetic variants as a possible cause of the disease were revealed, but additional studies are needed to confirm it. The most frequently mutated gene was MFN2 caused neuropathy in 6 unrelated families. MPZ gene mutations were detected in two families, AARS gene mutations were revealed in another two families, and mutations in GJB1, HINT1, INF2, LRSAM1, LITAF, MME, NEFL, WWOX were detected once. Among the causal variants, mutations in B4GALNT1 caused spastic paraplegia, in COL6A1 led to Bethlem’s congenital muscular dystrophy, and in SYT2 caused congenital myasthenic syndrome indicating difficulties in differential diagnosis of inherited neuromuscular disorders. A PMP22 duplication was detected in 2 families prior to whole exome sequencing.

Conclusion. Whole exome sequencing is very important for finding the molecular cause of hereditary motor and sensory neuropathies. In most cases, additional methods should be used to clarify the pathogenicity of variants detected by whole exome sequencing. However, it is necessary to remember that the most common cause of the disease is a large duplication of the region 17p11.2.
Clinical and genetic charsteristics of the Bosch–Boonstra–Schaaf syndrome due to novel mutations in the NR2F1 gene
Authors: Dadali E. L. , Borovikov A. O. , Shchagina O. A. , Mironovich O. L.
Published: December 2020

Bosch–Boonstra–Schaaf optic atrophy is autosomal dominant disorder caused by mutations in the NR2F1 gene. Its common features include optic atrophy and / or hypoplasia, developmental delay, intellectual disability, attention deficit disorder, autism spectrum disorder, seizures, hearing defects, spasticity, hypotonia, and thinning of the corpus callosum. We report of the clinical and genetic characteristics of two patients with Bosch-Boonstra-Schaaf syndrome with newly detected of the missense mutations с.329T>C (p.Phe110Ser) and с.413G>A (p.Cys138Tyr) in the gene NR2F1. The existence of a polymorphism of the clinical manifestations of the syndrome has been shown, and the necessity of using exome sequencing in the diagnosis of neuro-ophthalmic diseases has been substantiated.
Specificity of recovery in acute motor axonal neuropathy with conduction blocks on the example of two clinical cases
Authors: Grishina D. A. , Suponeva N. A.
Published: December 2020

Introduction. The heterogeneity of the forms and severity of Guillain-Barre syndrome explains the variability of recovery: from rapid and complete (in most cases) to slow with the development of persistent residual deficiency (rarely). It is unclear how effective the Erasmus Guillain–Barre syndrome Outcome Scores and its modified version are for different forms of the disease.

The aim of the study – to demonstrate the features of recovery in acute motor axonal neuropathy with conduction blocks on the example of 2 clinical cases; to show the possibilities of Erasmus Guillain–Barre syndrome Outcome Scores and its modified version in predicting recovery in this form of the disease.

Materials and methods. Data from 2 patients with acute motor axonal neuropathy with motor conduction blocks were retrospectively analyzed. Calculation of the score and assessment of the prognosis of walking recovery by 6 months from the onset of the disease were performed using the online calculator International Guillain-Barre syndrome Outcome Study Prognosis tool in the acute period.

Results. In both patients, the forecast of recovery of walking by half a year from the onset of the disease on the Erasmus Guillain–Barre syndrome Outcome Scores and modified Erasmus Guillain–Barre syndrome Outcome Scores scales in the acute period was erroneous. In the first case, the total score on the Erasmus Guillain–Barre syndrome Outcome Scores and its modification in the acute period was 5 and 10 points respectively (poor prognosis), which foreshadowed a long rehabilitation process and incomplete recovery. However, the regression of disorders was dramatic and complete, and by the second month of the disease, only minimal motor disorders remained. In the second patient, on the contrary, the total Erasmus Guillain–Barre syndrome Outcome Scores and its modification during the period of increasing symptoms was 3 and 7 points respectively (good prognosis), while recovery was delayed – only by 5 months from the onset of the disease, the ability to move with support was restored.

Conclusion. The Guillain–Barre syndrome is a disease with a favorable prognosis for recovery. However, the prediction of regression of motor disorders should be approached carefully, because in some cases, generally accepted criteria and prognostic scales may not work. Acute motor axonal neuropathy with conduction blocks is a unique form of the disease that has pathophysiological and clinical-neurophysiological features, which should be taken into account when managing this category of patients.
SMALL BUSINESS: ESSENCE AND FUNCTIONS
Authors: Davydova A. A. , Koneva A. A.
Published: December 2020

The article discusses the key differences between the concepts of "business" and "entrepreneurship". Theoretical approaches to understanding the "small business" category are analyzed and systematized. The criteria for classifying a business entity as an MP in the Russian Federation and foreign countries are studied. The forms of MP subjects are defined in accordance with the legislation of the Russian Federation. The main types of MP subjects in the aspect of industries and spheres of economic activity are highlighted. The functions of small business are analyzed and systematized. As a result of the research, it is proved that the functions implemented by small businesses create favorable conditions for stimulating economic growth. The specifics of small industrial enterprises and their impact on the economy are established.
Subjective Well-Being of School Students in Situation of Self-Identification
Authors: Pavlenko K.V. , Bochaver A.A.
Published: December 2020

This exploratory study aims to analyse the factors that influence subjective well-being of high school students. The purpose of the study is to formulate hypotheses about the impact of the situation of self-identification on the school students’ subjective well-being. The research is based on 14 interviews with school students in 10th and 11th grades. These interviews showed how adolescents perceive the situation of transition from the status of schoolchildren to the status of school graduates, what aspects of this transition cause anxiety and stress, and what changes in the behavior and everyday life of schoolchildren are caused by the need to make educational and life choices. The results suggest that in schools with a highly competitive environment, in which students have higher educational aspirations, the stress from self-determination and planning for the future in adolescents is higher than in schools with a less competitive environment. The obtained data place the subjective well-being of the high schoolchild in a broader context of life path design and allow to formulate a hypothesis that it is the need to solve the age-related problem of self-determination that has a decisive influence on the experiences of adolescents of this age. Understanding how well-being is related to the characteristics of this transitional stage in adolescents’ life, on the one hand, and social factors, on the other, creates the basis for further analysis: identifying risk groups of schoolchildren, studying and revising strategies to improve their well-being.
EMPREENDEDORISMO POLÍTICO: AÇÕES CONSORCIADAS E POSSÍVEIS SOLUÇÕES PARA A CIDADE DE MAUÁ
Authors: Costa Esdras da Silva
Published: December 2020

A presente pesquisa tem como objetivo identificar as variáveis latentes relacionadas aos desafios que serão impostos para a gestão pública municipal de Mauá diante de um cenário econômico pós-pandemia (Covid-19). O artigo possui abordagem quantitativa, sendo o tipo de pesquisa classificada como exploratória, utilizando enquanto método a análise multivariada de dados por meio da Análise Fatorial Exploratória – AFE para validar os dados analisados. Enquanto resultados, a AFE identificou os seguintes parâmetros: KMO=0,845, p=0,000 e MSA 0,70. A AFE também identificou um único fator, denominado de ações consorciadas, estando as assertivas embasadas sob quatro eixos: (i) desenvolvimento econômico; (ii) transporte público; (iii) mobilidade urbana; e (iv) desenvolvimento institucional. Dessa forma, a pesquisa identifica que todos os eixos apresentados poderão integrar uma já existente agenda regional, sob a denominação de ações consorciadas, de acordo com a variável latente identificada pela técnica de AFE.
CARACTERIZAÇÃO CIENTÍFICA E SUAS TENDÊNCIAS METODOLÓGICAS NA CONSTRUÇÃO DO CONHECIMENTO DOS ENFERMEIROS
Authors: Nerillo Lívia , Rodrigues Anderson Alexandre , Teixeira Jorge Juarez Vieira
Published: December 2020

O presente artigo tem por finalidade a reflexão sobre o conhecimento científico e suas tendências metodológicas na construção do conhecimento prático dos enfermeiros. Para tanto, pretendeu-se responder a seguinte problemática: quais são os fundamentos epistemológicos da prática dos enfermeiros? E quais são as tendências metodológicas do universo científico dos enfermeiros? Assim, com o levantamento bibliográfico, descritivo e exploratório, investigamos os periódicos e indexação científica disponível em três bases eletrônicas online, de 2014 a 2018. Desde a imersão exaustiva, na construção sistemática, coerente, concisa e pontual do tema até as análises práticas do exercício profissional dos enfermeiros. Nesse sentido, foi possível constatar que para experimentar alguns legados, rotulados sobre a “arte do cuidado”, é necessária uma ciência natural existencial e essencial, do desempenho do profissional de enfermagem de alto nível, no sentido que é assumido como verdade, muito além do conhecimento científico, pedagógico, puro e significativo, na construção do conhecimento da profissão. Além disso, o grande impacto nas competências para o trabalho, que, não despertam interesses suficientes, para uma hierarquia profissional heterogênea. Chegando ao caso em que as tendências epistemológicas são inseparáveis estabelecidas, ao raciocínio direto do conhecimento, onde, novas posturas científicas e ideológicas podem ser exploradas, para o contexto de ensino, a priori, na graduação em enfermagem.
ESTRUTURA DAS TESES DE DOUTORADO PREMIADAS PELA CAPES NA ÁREA DE ADMINSTRAÇÃO
Authors: Sousa Rony Castro Fernandes de , Costa Priscila Rezende da , Bittencourt Vitor da Silva
Published: December 2020

Programas de pós-graduação do país e do exterior têm adotado uma nova estrutura de tese, em formato de estudos interligados. Dado ao pouco tempo que este formato de tese começou a ser apresentado no Brasil não existe um padrão único. Para tanto, o objetivo geral é analisar as estruturas das teses de doutorado premiadas pela Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) na área de administração. Para tal, a pesquisa foi exploratória, de natureza qualitativa, e o método adotado foi a pesquisa documental junto às teses de doutorado premiadas pela (CAPES) na área de administração, contemplando o período de 2006 até 2016. Os resultados agregados possibilitaram o avanço do conhecimento sobre a pesquisa científica em ciências sociais, especificamente na área de administração, mediante o levantamento e análise das estruturas adotadas na elaboração de teses de doutorado de excelência reconhecida pela CAPES. Especificamente para os estudantes de doutorado da área de administração, o entendimento das estruturas mapeadas pode auxiliar nas decisões de delineamento metodológico dos entregáveis, oferecendo ao pesquisador e também aos futuros leitores uma visualização sistematizada e coerente da pesquisa de doutoramento, seja ela composta por estudo individual ou estudos distintos e interligados.
RP-T-Fuzzy Soft Subrings and Ideals of Soft Rings
Authors: AKIN Canan , AKÇAY Ertuğrul
Published: December 2020

In this paper we introduce a concept which is called RP-T-fuzzysoft subring and examine some properties of the restricted intersection, therestricted union, the ∧-intersection and the product of their families. A con-dition to make the restricted union of RP-T-fuzzy soft subrings of a soft ringto be RP-T-fuzzy soft subring of this soft ring is determined. A correlationbetween the RP-T-fuzzy soft subring of a soft ring and α-level sets of this softring is demonstrated. The RP-T-fuzzy soft subrings under some binary opera-tions are investigated. Moreover, the image and pre-image of RP-T-fuzzy softsubrings under fuzzy soft homomorphisms is examined. Finally, we present theconcept of RP-T-fuzzy soft ideal and we investigate the analogue propertiesfor them.
Some generalised integral inequalities for bidimensional preinvex stochastic processes
Authors: OKUR Nurgül
Published: December 2020

In this study, we generalized some integral inequalities
for bidimensional preinvex stochastic processes. For this reason, we used
mean-square integrable preinvex stochastic processes on the real line and on the
coordinates, respectively. Therefore, we obtained some generalized integral
inequalitİies for preinvex stochastic processes on the real line.
Phase and chemical structure characterization in double sided TIG arc welding of HARDOX 450 and AISI 430 steel
Authors: TEKER Tanju , GENÇDOĞAN Denizer
Published: December 2020

In this study, HARDOX 450 and AISI 430 grades are combined using double-sided tungsten inert gas (TIG) welding process. Microstructural properties of weld zone were evaluated with optical microscope (OM), scanning electron microscope (SEM), energy dispersive spectroscopy (EDS), electron back scatter diffraction (EBSD), elemental mapping analysis. After tensile testing, fracture surface morphology was evaluated using SEM. The width and depth of the weld seam increased with the increase in current. Carbon and chrome diffusion gradients were formed on the HARDOX 450 steel side by FSS in welded joints. The crystallographic plane was dominated by blue and, concentrated in the direction of {101}, {001}, {111}.
On Some bounded Operators and their characterizations in Г-Hilbert Space
Authors: ISLAM Sahın Injamamul
Published: December 2020

Some bounded operators are part of this paper.Through this paper we shall obtain common properties of Some bounded operators in Г-Hilbert space. Also, introduced 2-self-adjoint operators and it’s spectrum in Г-Hilbert Space. Characterizations of these operators are also part of this literature.
Occupational Noise Exposure in Natural Stone Proccesing Plants
Authors: DURAN Zekeriya , DOĞAN Tuğba , ERDEM Bülent
Published: December 2020

Occupational noise exposure is a serious physical risk factor leading to occupational diseases including hearing loss. In this study, occupational noise measurements taken at seven natural stone processing plants operating in Sivas, Turkey and its environs are evaluated in accordance with the task-based assessment method given in TS EN ISO 9612-2009 standard. Though the processes in natural stone processing plants are similar, significant differences were observed in the noise levels, which are often above the limits specified in the relevant regulation. The highest noise levels to which workers were exposed are S/T, bridge cutting, sizing/honing, head/side cutting machine while the lowest noise levels were from narrow polishing machine and gang saw machines. In plants B, F and G the S/T block cutting machines, in plants B and D the head/side cutting machines, in plants C and E the sizing/honing machines and in plant D the bridged cutting and narrow polishing machines exposed workers to noise levels above the lowest exposure action value of 80 dBA. The bridge cutting machine in plant D exposed the workers to noise levels above the highest exposure action value of 85 dBA. High noise emitting machines were proposed to be isolated in separate compartments.
Biological Activity of Some Pyrimidine Derivatives: Cytotoxicity and Oxidative Stress Potential in Human Lung Cancer Cell line (A549).
Authors: ABUDAYYAK Mahmoud , ŞAMLIOĞLU Fatma Betül , SELEN Beyza , FANDAKLI Seda , YAYLI Nurettin
Published: December 2020

Compounds with pyrimidine ring in their structure have many biological activities including antimicrobial, antiviral and anticancer. Recently, studies related to their synthesis and so their applications have increased. In a previous study, a solid-phase microwave method was used to synthesized 25 new hydroxy- and methoxy-substituent 4,6-diarylpyrimidin-2 (1H) -ol and 4,6 diarylpyrimidin-2 (1H) –thiol compounds. In the present study, as a preliminary estimation of the anticancer activity, the cytotoxicity and oxidative stress induction potential of 6 derivatives that show highest antibacterial activities was evaluated in human lung epithelial cancer cell line (A549). Results of the 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) cytotoxicity test indicate that pyrimidine derivatives caused concentration-dependent cell death that IC50 values were calculated between 16.7 and 41.5 µg/mL. additonally, pyrimidine derivatives induced significant changes in malondialdehyde (MDA) and glutathione (GSH) levels and catalase (CAT) activity; oxidative stress could be the mechanism of action of the tested pyrimidine derivatives in the cancerous cells. The results could be used to design the further in vivo and in vitro detailed studies to appreciate these pyrimidine derivatives anticancer activity, compare this activity with in-use known drugs, elucidate their mechanisms of action and estimate their safety.
Different methods of estimation for the one parameter Akash distribution
Authors: KARAKAYA Kadir , TANIŞ Caner
Published: December 2020

Akash distribution is a mixture of an exponential distribution and a gamma distribution with certain mixing proportions. Although the maximum likelihood estimation method has been proposed for the Akash distribution, there is no comprehensive comparison of different methods of estimation in the literature. This study provides five different methods of estimation, such as maximum likelihood, least-squares, weighted least-squares, Anderson-Darling, and Crámer–von-Mises for Akash distribution. We consider a comprehensive Monte Carlo simulation study to compare the performances of these methods via the biases and mean-squared errors of these estimators. Also, a real data application is performed.
Prediction of UEFA champions league elimination Rounds winners using machine learning algorithms
Authors: KINALIOĞLU İsmail Hakkı , KUŞ Coşkun
Published: December 2020

In this study, the teams that qualified for the next round as a result of two-legged matchups are predicted using the data collected from the UEFA (Union of European Football Associations) Champions League group stage matches. The study contributes to the literature in terms of variety of methods used and content of the dataset compared to other studies conducted on football data. It is also a pioneering study to predict the outcome of a two-legged matchup. The data are collected from the matches played in the Champions League organizations held between 2010-2018. Classification methods as Artificial Neural Network, K-Nearest Neighbors, Logistic Regression Analysis, Naive Bayes Classifier, Random Forest and Support Vector Machine are used for the prediction. Two applications are carried out to test the successes of the classification models. In the first application, the most successful method is naive bayes classifier (86.66%) and in the second application, the most successful method is random forest (74.81%).
2-Dimensional Investigations of In-Cyclinder Flow and Turbulence at Suction Stroke in Internal Combustion 4-Stroke Engines
Authors: CAN İbrahim , GÜLDEŞ İlyas
Published: December 2020

Studies and experiments conducted for the performance enhancement of internal combustion engines are of great importance. Today, challenges encountered in securing energy resources, the incremental costs and environmental factors constantly remind us that we should not ignore fuel economy in motor vehicles. Studies conducted in this framework focus on lower fuel consumption and less exhaust emissions while improving performance. Undoubtedly, combustion chamber designs and charge systems have a great effect on exhaust emissions and performance. For this reason, a suction stroke was modeled in two dimensions using the fluent software to better understand the charge systems in internal combustion engines. The design was based on 1600 cc Fiat engine measurements and engine geometry was defined. CFD (Computational Fluid Dynamics) software was used to investigate the valve opening and cylinder and combustion chamber air motion at 900, 3000, 5000 rev-1 RPM and the results were discussed in detail. CFD results will assist engine designers in understanding the effects of suction system and its components on various parameters.
A Comparison of Ground-Motion Parameters for the Vertical Components from the Western and the Southwestern Parts of China with Recent Ground-Motion Prediction Equations
Authors: Xing Hao , Zhao John X.
Published: December 2020

This study evaluated the source, path, and site effects of the vertical ground motions from the western and the southwestern parts of China (referred to as SWC hereafter) using 2403 records from 449 earthquakes, including the records from the 2008 Mw 7.9 Wenchuan earthquake and its aftershocks. Only 677 records are from 73 mainshocks, and 259 events do not have a known focal mechanism. There is a large magnitude gap in the dataset, for example, there is only one event between Mw 6.3 and Mw 7.8. The average numbers of records per recording station and per earthquake are small, and many sites do not have a measured shear-wave velocity profile. These shortcomings make it difficult to develop a robust ground-motion prediction equation (GMPE) without adding overseas data or using a reference GMPE developed from a large dataset. We compared the SWC dataset with five recent GMPEs, three based on the Next Generation Attenuation-West2 dataset, one based on Europe and the Middle East, and one based on the shallow-crustal and upper-mantle earthquakes in Japan. We decomposed the total residuals for each model into constant term, between-event, and within-event residuals and calculated the corresponding standard deviations. The maximum log likelihood and the standard deviations suggest that, among the five GMPEs, the Zhao et al. (2017) model without the normal-fault term may be the most suitable GMPE for a probabilistic seismic hazard study in the SWC region. Correction functions based on simple magnitude, path, and site effect parameters were used to correct the residuals and to obtain the leftover between- and within-event standard deviations. These standard deviations appear to suggest that the GMPE from Zhao et al. (2017) without a normal-fault term may be the most suitable reference GMPE for developing a new GMPE for the SWC region.
Karakteristik Mutu dan Sensori Nugget Ikan Patin (Pangasius hypopthalmus) dan Nangka (Artocarpus heterophyllus) Muda
Authors: Ayu Dewi Fortuna , Sormin Diana Sari , Rahmayuni Rahmayuni
Published: December 2020

The purpose of this research was to study the effect of catfish and young jackfruit ratio on quality and sensory nuggets.  A completely randomized design with four treatments and four replications was conducted in the research.  The treatments were PN1 (70 catfish meat: 30 young jackfruits), PN2 (60 catfish meat: 40 young jackfruits), PN3 (50 catfish meat: 50 young jackfruits), and PN4 (40 catfish meat: 60 young jackfruits).  Data obtained were statistically analyzed using analysis of variance and continued with Duncan's New Multiple Range Test (DNMRT) at a 5% level.  The results showed that the combination ratio of catfish and young jackfruit significantly affected water, ash, fat, protein, and crude fiber content, as well as descriptive sensory assessments such as color, aroma, taste, texture, and hedonic assessment of the nugget.  The best treatment was PN1 (70 catfish meat: 30 young jackfruit) which had fulfilled quality requirements of fish nuggets (SNI 7758-2013) i.e. 58.36% moisture content with a maximum value of 60%, 1.81% ash content with a maximum value of 2,5%, 4.94% fat content with a maximum value of 15%, 14.38% protein content with a minimum value of 5%, and 5.14% crude fiber content.  The overall sensory assessment of the nugget was a yellow color, flavorful of patins fish aroma, the very taste of patin fish (according to typical raw materials), and rather hard texture.
Analisis Mutu Sie Reuboh Dalam Kemasan (Ready to Eat) Selama 7 Hari Penyimpanan
Authors: Nilda Cut , Hasni Dian , Yusriana Yusriana , Erfiza Novia Mehra
Published: December 2020

Sie reuboh is a traditional cuisine from Aceh Besar district which use red meat, tallow, vinegar and some blended spices. Normally, Acehnese cooks this cuisine in with traditional clay pot. As cooking utensil, clay pot is vulnerable to breakage and has slow heat propagation compared to stainless steel pot which has long usage and good heat conductor. The use of packaging such as nylon plastic and aluminum foil in storage is also expected to affect the quality of sie reuboh. This study aims to find out sensory profile of produced sie reuboh by using ten attributes (colour/brightness, aroma (sour, spicy, meaty), flavor (hot spicy, sour, salty, umami) and texture (tenderness, chewiness). Sie reuboh was cooked in two types of cooking ware (earth clay pot and stainless steel pot) and then store in nylon and aluminum foil packaging for 7 days.  The obtained data is statistical analyzed with ANOVA and DMRT. The results showed that attribute sour aroma, hot spicy flavor, umami and tenderness of sie reuboh cooked with stainless steel has higher notes, whereas other attributes showed no significant effect. Type of packaging also showed no significant effect for these ten attributes except sour aroma. As conclusion, it can be stated  that  stainless  steel  provides  sie  reuboh  with  better  sensory  properties compare to clay pot.
Karakteristik Mi Basah Tapioka dengan Penambahan Kacang Pagar (Phaseolus lunatus)
Authors: Ikhlas Nahdatul , Fitriani Shanti , Rahmayuni Rahmayuni
Published: December 2020

Lima beans (Phaseolus lunatus) have been valued to increase proteins and improve the quality of wet noodles.  The purpose of this research was to get the best formulation of tapioca and lima beans paste on the quality and sensory character of wet noodles based on Indonesian National Standard.  This research was conducted experimentally by using a completely randomized design with four treatments and four replications.  The treatment in this research was the ratio of tapioca and lima beans paste such as 90:10, 80:20, 70:30 and 60:40.  Data obtained were statistically analyzed using analysis of variance and continued with duncan’s new multiple range test (DNMRT) at a 5% level.  The result of this research showed that the ratio of tapioca and lima beans paste significantly affected moisture, ash, protein, fat, starch, carbohydrate contents as well as elongation and sensory characteristic of color, flavor, elasticity, stickiness and taste.  The best treatment in this research was the ratio of tapioca and lima beans paste (70:30) where moisture content of 61.25%, ash content of 0.87%, protein content of 4.32%, fat content of 0.86%, starch content of 30.29%, carbohydrate content of 32.67% and elongation of 32.50%.  The descriptive test showed that wet noodles had yellow color, flavouring lima beans, chewy, a little sticky and lima beans taste and overall assessment hedonically was favoured by panelists. Keywords: wet noodles, tapioca and lima beans paste
Pentingnya olahraga selama pandemi COVID-19
Authors: Setyaningrum Dyah Ayu Woro
Published: December 2020

Pada tahun 2019, tercatat penyebab kematian utama di dunia adalah penyakit tidak menular, dan ranking pertama adalah penyakit jantung iskemik dengan persentase 16% dari total kematian sedunia, disusul stroke sebanyak 11% dan PPOK menyumbang 6%.(1) Saat ini dunia sedang berada ditengah-tengah krisis dengan skala yang sangat besar yang belum pernah terjadi sebelumnya di zaman modern ini, yaitu pandemi COVID-19 yang melanda ke seluruh penjuru dunia. Hingga tulisan ini dibuat per tanggal 14 Desember 2020 telah tercatat 70.8 juta kasus dan 1.6 juta kematian terkonfirmasi COVID-19.(2) Sementara penyakit-penyakit tidak menular yang disebutkan sebelumnya merupakan co-morbid yang penting terhadap keparahan dan outcome dari penderita COVID-19.
Influence of 4-(2-S(+)-Methylbutyloxy)Benzoic Acid on Mesomorphic and Physico-Chemical Properties of 4-Butyl-4'-Octanoyloxyazobenzene
Authors: Novikov I. V. , Aleksandriiskii V. V. , Burmistrov V. A. , Koifman O. I.
Published: December 2020

Mesomorphic, optical, dielectric, and orientation properties of nematic liquid crystal 4-butyl-4'-octanoyloxyazobenzene doped with chiral 4-(2-S(+)-methylbutyloxy)benzoic acid have been studied. The clearing temperatures of the mixtures were measured by polarizing microscopy. An estimation of the mesophase destabilization with the introduction of the dopant was carried out. The helix pitch of the induced chiral nematic mesophase was measured. The effect of the chiral dopant on anisotropic characteristics of the mesophase has been studied. An insignificant increase in the optical and dielectric anisotropy is associated with the formation of liquid crystal – dopant supermolecules due to hydrogen bonds –COOH…OCO–.
The effect of vitamin D3 supplements on the 25(OH)D levels in the II and III trimester of pregnant women in Sleman, Indonesia: randomized controlled trial
Authors: Susilani Amalina T. , Subagio Hertanto W. , Pramono Noor , Kartasurya Martha I.
Published: December 2020

Background: Pregnant women are among the groups at high risk of vitamin D3 deficiency due to the increased need for micro and macro nutrients during pregnancy. Vitamin D3 deficiency is associated with pregnancy complications, namely preterm birth, pre-eclampsia, gestational diabetes, and babies born small according to their gestational age.Methods: The study involved a randomized pretest-posttest control group design. Subjects selected include 80 pregnant women in second trimester. Data were collected in June 2020 to September 2020. The respondents were then randomly divided into 2 groups, comprising 40 each, where the first received 400 IU/day vitamin D3 supplementation for 12 weeks, and the second served as a control. Furthermore, 25 (OH) D were measured by using the ELISA method.Results: The mean value of the 25(OH)D levels after D3 supplementation and statistically showed a significant difference with a significance value of p<0.05 (0.01), compared to the control group.  Furthermore, the mean value of the 25(OH)D levels in the control group actually decreased by 2.7 ng/ml which was statistically significant with a p value of 0.00, compared to the control group. Furthermore, the mean value of the 25(OH)D levels in the control group actually decreased by 2.7 ng/ml which was statistically significant with a p value of 0.00.Conclusions: Vitamin D3 supplement of 400 IU per day can increase the levels of 25(OH)D in the II and III trimester of pregnant women in antenatal care (ANC), Sleman Regency, Yogyakarta.
The role of serological tests and biopsy in the diagnosis of celiac disease: retrospective review of 1137 duodenal biopsies
Authors: Gurlek Feridun , Tasdemir Eyyup , Erkinuresin Taskın
Published: December 2020

Background: The aim of this study is to evaluate gluten sensitivity and/or celiac disease (CD) on the basis of serological tests and duodenal biopsy and to draw attention to the prevalence in the population and the correlation between serological tests and biopsy results.Methods: Patients who applied to Health Sciences University Bursa High Specialization Training and Research Hospital between 2015-2019 and who underwent serological tests and duodenal biopsies with a diagnosis of CD or gluten sensitivity were retrospectively analyzed.Results: The study was conducted with a total of 1137 cases, 61.2% (n = 696) of who were women and 38.8% (n = 441) were men. Their ages range from 17 to 91, with a mean of 40.16 ± 16.18 years. Of the 178 patients with gluten sensitivity, 122 (68%) were female and 56 (32%) were male. According to the results of duodenal biopsy, an average of 8% Marsh 3, 5% Marsh 1-2 was detected in the last five years. For the whole study, a significant difference was found between celiac autoantibody positivity rates according to the biopsy results (p = 0.001; p <0.01). The rate of serological test positivity was higher in patients with biopsy result Marsh 3 than those with normal biopsy result, peptic duodenitis and Marsh 1 and 2. No statistically significant difference was found between the rates of Marsh 3 biopsy results and serological test positivity by years (p> 0.05).Conclusions: The number of patients applied with a diagnosis of CD in the last five years has gradually increased (3.4-33.7%). Of the patients with Marsh 3 and Marsh 1-2 biopsy results, 78% were under 50 years old. This suggests that gluten enteropathy in young female patients having digestive system complaints should not be ignored during the diagnosis. Serological test results were highly correlated with the biopsy results in patients with Marsh 3 biopsy results. We think that if clinical findings are supported with serological tests and directed for biopsy in the diagnosis of celiac disease, it will be more cost effective and the workload and time loss will be prevented.
Epidemiological and clinical profile of snakebite patients: a retrospective analysis at a tertiary care teaching hospital of southern Rajasthan, India
Authors: Paliwal Sanjay Kumar , Javed Syed , Shah Arth
Published: December 2020

Background: Snakebite - a global public health problem can be a traumatic experience for patients. They may develop local pain and swelling at the site with or without systemic involvement (haematological and neurological) and at times complications depending upon nature of snake. The present study was planned to determine the epidemiological and clinical profile of snakebite patients at a tertiary care teaching hospital of southern Rajasthan, India.Methods: This retrospective observational study was carried out at a tertiary care teaching hospital only after approval from institutional ethics committee. The data of patients aged between 18-80 years of either gender that had presented with a history of snakebite and admitted to the intensive care unit (ICU) in past 3 years were included. Data related to epidemiological, clinical and investigational parameters was collected and analysed. Data was presented as number (percentage) or mean ± standard deviation.Results: Total 80 patients were analyzed. Male:female ratio was 1.67:1 and mean age of study population was 33.91±14.34 years. Maximum 71 (89%) patients belonged to rural region. Only 16 (20%) patients complained of local pain. Bleeding was noted in 5 (6.25%) patients whereas 36 (45%) patients had ptosis. Prolonged coagulation markers were reported in 35 (44%) patients. Only 2 (2.5%) patients had acute kidney injury. Altered liver and renal function tests were noted in 71 (89%) and 63 (79%) patients respectively. Mechanical ventilation was required in 27 (34%) patients.Conclusions: Young adult males and rural population were prone to snakebites. Local and systemic manifestations were noted in relatively lesser patients compared to the published data. Only fewer patients in I.C.U. required mechanical ventilation.
A study of the correlation of serum vitamin D levels to Child-Pugh and MELD-Na scoring system in cirrhosis of the liver
Authors: Patel Jitendra Kumar , Mahur Hemant Kumar , Jat Shaitan Singh , Singh D. P.
Published: December 2020

Background: Vitamin D is a hormone with known effect on calcium homeostasis, but recently there is increasing recognition that it also is involved in cell proliferation and differentiation, has immunomodulatory and anti-inflammatory properties. These effect may explain its importance in the liver diseases. Vitamin D deficiency has been reported highly prevalent in Chronic liver disease (CLD) and there is an emerging interest to explore the relationship of vitamin D deficiency and severity of CLD. The aim of the study was to evaluate the correlation of serum vitamin D levels to the Child Pugh and MELD-Na scoring system in liver cirrhosis and to establish its relationship with the severity of the disease.Methods: Serum vitamin D levels were measured in 100 patients of CLD and 100 healthy controls. The degree of liver dysfunction was estimated by Child-Pugh and MELD-Na scores.Results: 91% of the CLD patients had subnormal vitamin-D levels. The mean vitamin D level in CLD patients was lower (15.97±7.45) than controls (30.12±6.60) with statistical significance (p= 0.0001). On linear regression vitamin D level showed significant negative correlation with Child Pugh score (r= –0.446, p<0.001) and MELD score (r= –0.395, p<0.001). Low vitamin D level was associated with poor outcome (mean vitamin D level 9.61±3.01 who died versus 16.52±7.47 who survived and discharged).Conclusions: CLD is associated with a significantly low level of vitamin D. The lower level of vitamin D is associated with severity of CLD, mortality and increased risk for complications. Awareness of serum vitamin D level in CLD patients is important to improve outcome.
Study of anatomical variations of mental foramen in dry adult human mandible
Authors: Acharya Sunita , Mehta Rupali , Kattimuthu Prabhakaran Pearl
Published: December 2020

Background: Mandible also known as the largest and inferior, primary facial bone of the face giving a curved shape to it. It changes its shape and gives variations to the bony structure of the face from birth till older age. Mental foramen is known as the ventage of the mandible and is an important mark of the face for carrying out many diagnostics and surgical processes along with anesthetic procedures of the face. Thus, the present study is designed with an aim to get insight knowledge of position and shape of mental foramen in dry adult human mandible.Methods: Totally, 60 bones were studied in 2 years duration. The study was carried out in the Department of Anatomy of Geetanjali Medical College and Hospital and Rabindranath Medical College. The position of mental foramen was studied using an instrument known as digital Vernier Calliper (in mm) while shape was analyzed visually. Position of mental foramen was calculated using Statistical package for social sciences (SPSS) software.Results: The present study showed that the position of mental foramen from symphysis menti and posterior border of ramus of mandible was more from right side than left side and found to be insignificant while position of mental foramen from inferior border of body of mandible was more from left side than right side and found to be insignificant for right side while significant for left side. The shape of mental foramen from right side was found to be (Oval shape- 68.33% and round shape – 31.66%) while for left side was found to be (Oval shape- 71.66% and round shape – 28.33%).Conclusions: Hence, mental foramen plays a pivotal role in performing major facial surgeries and is an important landmark for several facial procedures performed.
New challenge of asymptomatic infections from COVID-19: current scenario
Authors: Verma Nidhi , Verma Vikas , Sagar Harish Kumar , Singh Neha , Karuna Veer , Gupta Priya , Singh Anshu
Published: December 2020

Since the outbreak of coronavirus 2019 (COVID-19) disease in China, late December 2019, it took a substantial detriment and challenges for more than 200 countries worldwide. Recently with the upcoming insights about etiology of the virus, there is increasing evidence that many patients with COVID-19 are asymptomatic or they have only mild symptoms, but they act as carrier and are able to transmit the virus to others. There are technical difficulties in screening for these asymptomatic infections, which makes it even more challenging for any nation to control this epidemic. This article reviews entry & replication of the virus, pathogenesis, asymptomatic infections, dissemination, prevention, control & treatment in asymptomatic infections with COVID-19, expecting it would be helpful for early prevention and containment of this severe public health threat worldwide.
Space occupying lesions of liver- clinical presentation, investigations and management: a longitudinal study
Authors: Sonarkar Rajiv , Gajendra Giriraj , Wilkinson T. R. V. , Sonawane Shreyas
Published: December 2020

Background: Liver is a common site for space occupying lesions. The objective of this study was to determine the aetiologies of space occupying lesion of liver and their clinical presentation and correlate imaging; to evaluate the treatment modalities of space occupying lesion of liver and their outcome.Methods: A 2-year tertiary care teaching hospital based longitudinal study with 63 patients was done. Selection criteria was defined and a prestructured proforma was made to assess and note the findings.Results: The mean age of occurrence of space occupying lesions of liver was 47.19±14.53 years. Space occupying lesions of liver was commonly observed in 5th decade of life. Males were affected more than females. Metastatic lesion of liver were the most common cause of liver SOL (34.9%) followed by liver abscesses.Conclusions: Majority of space occupying lesions are metastatic lesion followed by liver abscesses. Majority of space occupying lesions were surgically managed.
A prospective study of single dose preoperative antibiotic cover in clean elective surgical cases- a single center study
Authors: Subramaniyan Siddhartha Gowthaman , Gunasekaran Prabhu , Manickam Ramanathan
Published: December 2020

Background: Surgical site infection (SSI) is the third most common nosocomial infections occurring worldwide, thus leading to increasing cost, mortality and morbidity. The main objective was to know the incidence of SSI in clean surgical procedures carried out in the institute of MGMCRI and to determine various pathogens causing SSI.Methods: This was a prospective observational study done on 100 patients in Department of General Surgery in MGMCRI, Puducherry from June 2015 to August 2017 who underwent clean surgical procedure. Preoperatively single done of injection cefazolin 1gm intravenous preparation was given 30 minus before the skin incision and patient were observed and followed up meticulously for the incidence of SSI and to determine the bacterial flora in the event of SSI.Results: In our study a total of 100 patients were included.  In our study a total of three out of 100 patients developed SSI which was around 3%.Out of the 3 patients who had SSI all were a male which is around 4.6% in our study. In relation to the distribution based on the age group more than 50 year of the age are most frequently associated with SSI in our study. The bacterial flora includes staphylococcus aureus which was isolated from one patient and Klebsiella pneumonia isolated from two patients who had surgical site infections.Conclusions: This study concludes that single dose pre-operative antibiotic has advantage in prevention of SSI and it is cost effective for patient.
Gastrointestinal duplication cysts: experience from a tertiary care center in North India and review of literature
Authors: Aggarwal Divya , Vaiphei Kim
Published: December 2020

Background: Duplication cysts (DC) are uncommon congenital malformations which predominantly present in infants and young children. Owing to their variable clinical presentation, radiology and/or histopathology are often required to clinch the diagnosis. We present a case series of 66 patients, which is the largest series reported so far.Methods: A search of prospectively maintained institutional database was carried out to identify patients who were diagnosed and operated for gastrointestinal DC between January 2013 and August 2018. For all cases, the demographic data, site of DC, details of clinical presentation, associated conditions and histopathology findings were recorded. The slides of all cases were retrieved and re-examined.Results: The age range was 1 day to 47 years, with a slight male predominance (1.3:1). Ileum was the most common site followed by jejunum. Ectopic mucosae noted were gastric, pancreatic, biliary and respiratory. One case showed glial heterotopia. Perforation, gangrene and intussusception were among the co-existing pathologies noted.Conclusions: Duplication cysts are rare congenital malformations. The variability in clinical presentation makes the diagnosis elusive. Timely diagnosis and appropriate management require a high index of suspicion and a holistic diagnostic approach with clinical, radiological and histopathological inputs.