bluuebunny/crossref_metadata_2025 huggingface dataset:
Prevalence and sociodemographic correlates of food insecurity among post-secondary students and non-students of similar age in Canada
Authors: Wang Yichun , St-Germain Andrée-Anne Fafard , Tarasuk Valerie
Published: May 2023

Background

The results of several recent campus-based studies indicate that over half of post-secondary students in Canada are food insecure, but the vulnerability of this group has not been considered in research on predictors of food insecurity in the Canadian population. Our objectives were to (1) compare the prevalence of food insecurity among post-secondary students and non-students of similar age; (2) examine the relationship between student status and food insecurity among young adults while accounting for sociodemographic characteristics; and (3) identify the sociodemographic characteristics associated with food insecurity among post-secondary students.

Methods

Using data from the 2018 Canadian Income Survey, we identified 11,679 young adults aged 19–30 and classified them into full-time postsecondary students, part-time post-secondary students, and non-students. Food insecurity over the past 12 months was assessed with the 10-item Adult Scale from the Household Food Security Survey Module. Multivariable logistic regression analyses were used to estimate the odds of food insecurity by student status while accounting for sociodemographic characteristics, and to identify sociodemographic characteristics predictive of food insecurity among post-secondary students.

Results

The prevalence of food insecurity was 15.0% among full-time postsecondary students, 16.2% among part-time students, and 19.2% among non-students. After adjusting for sociodemographic factors, full-time postsecondary students had 39% lower odds of being food insecure as compared to non-students (aOR 0.61, 95% CI 0.50–0.76). Among postsecondary students, those with children (aOR 1.93, 95%CI 1.10–3.40), those living in rented accommodation (aOR 1.60, 95%CI 1.08–2.37), and those in families reliant on social assistance (aOR 4.32, 95%CI 1.60-11.69) had higher adjusted odds of food insecurity, but having at least a Bachelor’s degree appeared protective (aOR: 0.63, 95% CI 0.41–0.95). Every $5000 increase in adjusted after-tax family income was also associated with lower adjusted odds of food insecurity (aOR 0.88, 95%CI 0.84–0.92) among post-secondary students.

Conclusions

In this large, population-representative sample, we found that young adults who did not attend post-secondary school were more vulnerable to food insecurity, particularly severe food insecurity, than full-time post-secondary students in Canada. Our results highlight the need for research to identify effective policy interventions to reduce food insecurity among young, working-age adults in general.
Alveolar bone changes following bi-maxillary vertical molars’ movements using clear aligners
Authors: Al-Warafi Leena Ali , Al-Worafi Naseem Ali , Al-Aroomi Maged Ali , Alhashimi Najah , Alsomairi Majedh Abdo Ali , Al-Rokhami Remsh Khaled , Chen Xi , Alhammadi Maged Sultan
Published: May 2023

Objective

This study aimed to assess the alveolar bone changes following maxillary and mandibular molars’ intrusion and extrusion movements using Clear Aligners using Cone-Beam Computed Tomography (CBCT).

Materials and methods

This is a retrospective clinical study in which 24 adult patients with pre-designed selection criteria and a mean age of 31.1 + 9.9 years were enrolled. The alveolar bone changes around one hundred thirty-three maxillary and mandibular molars intruded or extruded by Clear Aligners therapy were analyzed from CBCT using Invivo 6.0 software. Intra- and inter-examiner reliability analysis was performed using the intra-class correlation coefficient (ICC) and Cronbach’s Alpha statistics. The paired t-test was used to analyze significant differences before and after treatment (T0-T1). The significance level was considered at P < 0.05.

Result

The patients were divided into two groups: extrusion (48.9%, n = 65 molars’ root) and intrusion (51.1%, n = 68 molars’ root) group. There was a significant decrease in the alveolar bone changes in the buccal surface of the mandibular right and left 1st molars in the extrusion group (-1.05 ± 0.97, -0.76 ± 1.12 mm, respectively) and the maxillary left 2nd molars in intrusion group (-0.42 ± 0.77 mm), and the lingual surface of intrusion of the mandibular left 1st molar (-0.64 ± 0.76 mm). Comparing the mean maxillary and mandibular changes (T0-T1) of both studied groups showed that the buccal alveolar bone changes for the left 1st and right 2nd molars showed a significant difference in extrusion and intrusion groups, respectively.

Conclusions

The buccal alveolar bone changes is considered the most affected surface following maxillary and mandibular molars’ intrusion and extrusion movements using clear aligners, with mandibular molars being more affected than the maxillary ones.
Experiences of dysmenorrhea and its treatment among allistic and autistic menstruators: a thematic analysis
Authors: Gray Lauren J. , Durand Hannah
Published: May 2023

Background

Dysmenorrhea (i.e., period pain) is common and debilitating. Autistic people are known to experience pain differently, yet little is known about the menstrual pain experiences of autistic menstruators relative to non-autistic peers. This study aimed to explore the experience of period pain and treatment uptake for period pain among allistic and autistic populations.

Methods

This study used a qualitative design and opportunity sampling approach. Thirty-seven participants (of whom 17 were autistic) were interviewed via video-conferencing software using a semi-structured topic guide. Transcriptions of interviews were analysed using Braun and Clarke’s Reflexive Thematic Analysis. Data were initially analysed together for common themes. Autistic menstruators’ data was subsequently analysed separately to elucidate the unique experiences of this group.

Results

A total of six themes were constructed from the data. Initial analysis determined three themes related to experiences of period pain and treatment uptake in both allistic and autistic menstruators. Social perception of menstruation was discussed, highlighting the normalisation of pain, the taboo nature, and gendered experience of menstruation, contributing to untreated menstrual pain. Issues within menstrual healthcare were also shared, including experiences of ineffective treatment, dismissive interactions, and insufficient menstrual education. Impaired functionality was repeatedly highlighted, with menstruators detailing significant limitations to their usual functioning due to menstrual pain and ineffective treatment. Three further themes were constructed from separate analysis of data from autistic menstruators. Autistic menstruators discussed the impact of menstruation on their sensory experiences and needs, with many identifying overstimulation during menstruation. Social exclusion was discussed as a factor contributing to the experience of menstrual pain and poor treatment uptake. The final theme identified pain communication differences between autistic and allistic menstruators resulting in reports of ineffective treatment and challenges in healthcare interactions.

Conclusions

Communication differences, sensory aspects, and social factors contributed to the experience of period pain and treatment uptake for autistic menstruators. The perception of menstruation within society was highlighted by allistic and autistic menstruators as influential to their pain experience and engagement with treatment. Functionality was significantly impacted by pain for this sample. The study highlights societal and healthcare factors that could be improved to ensure accessibility of support and treatment for menstrual issues.
Perceptions of professional social media interaction with patients and faculty members – a comparative survey among dental students from Malaysia and Finland
Authors: Mani Shani Ann , Uma Eswara , John Jacob , Nieminen Pentti
Published: May 2023

Background

Professional and personal boundaries are blurred with the wide application of social media (SM) in the health professions line of work. Little is known about practice of extending friend requests to patients and faculty members among dental students, which encompass a part of E-professionalism. The aim of this study is to assess the factors associated with the perceptions and practices of interactions with patients and faculty on SM among dental students from Malaysia and Finland.

Methods

Dental students from 4 institutions in Malaysia and Finland completed self-administered questionnaires on the practices and perceptions of SM use. The main variables assessed were the perceptions and practices of student-patient and student-faculty communication on SM, between the two countries. Students’ country, age, gender, time spent on SM and perceived importance of communicating dental related aspects over SM were analysed as potential explanatory variables. Crosstabulation was used to estimate the distributions of the response variables by the background characteristics. Multivariate analyses were performed using a dichotomous logistic regression model to investigate relevant associations between the responses and the explanatory variables independent from other factors.

Results

A total of 643 students completed the survey in March-April 2021. More Malaysian students agreed with “guiding patients online is a new responsibility for dentists in the digital age” compared to Finnish students (86.4% vs. 73.4%). Similarly, significantly more Malaysian students befriended patients (14.1% vs. 1%) and invited faculty to be friends on SM (73.6% vs. 11.8%). Expectedly, clinical year students befriended patients more than pre-clinical (13.8% vs. 6.8%). Significantly more students who felt ‘communication of dental related issues over SM’ were likely to extend friend requests to faculty rather than accept patient friend requests.

Conclusions

Social media regulations and socio-cultural practices contribute to dental students’ attitudes and behaviour when befriending patients and faculty members on social media. Future dental curriculum should incorporate guidelines for professional communication on social media based on local and cultural needs. Students’ should be encouraged to interact with their patients using professional identities on social media.
Effect of educational intervention based on health belief model on nurses’ compliance with standard precautions in preventing needle stick injuries
Authors: Alinejad Navid , Bijani Mostafa , Malekhosseini Mahmoodreza , Nasrabadi Mahsa , Harsini Pooyan Afzali , Jeihooni Ali Khani
Published: May 2023

Background

The increasing prevalence of needle stick injuries among nurses and the arising risks double the need to pay attention to improve their knowledge and change their behavior using effective educational models. The present study aimed to investigate the effect of educational intervention based on the health belief model on nurses’ compliance with standard precautions in preventing needle stick injuries.

Methods

This quasi-experimental study was conducted on 110 nurses working in medical training centers in Shiraz and Fasa in 2019. Subjects were selected using a simple sampling method and were randomly divided into two interventions (n = 55) and control (n = 55). The intervention included 7 sessions of 50–55 min. Before and 3 months after the intervention, the health belief model questionnaire was completed by both groups. The data were analyzed using SPSS software version 22 through chi-square, independent, and paired t-tests (P < 0.05).

Results

Based on independent and paired t-tests, there was no significant difference between the control and intervention groups regarding the mean score of health belief model constructs before the intervention. However, there was a significant difference regarding the mentioned scores 3 months after the educational intervention. Based on the paired t-test, the mean score of awareness, perceived sensitivity, perceived severity, perceived benefits, self-efficacy, cues to action, and behavioral performance in the intervention group significantly increased after the educational intervention (P < 0.05). Also, there was a significant decrease in perceived barriers (P < 0.05).

Conclusion

It is recommended to apply the proposed model as an effective and cost-effective method along with other methods in training programs for nurses and other health workers exposed to invasive procedures, contaminated blood, and secretions.
Who consumes curative care expenditure of medical institutions in Beijing: a case study based on System of Health Accounts 2011
Authors: Jiang Yan , Man Xiaowei , Shi Xuefeng , Zhao Liying , Yang Wanjin , Cheng Wei
Published: May 2023

Background

China’s health system is challenged by complex health problems experienced by different population groups and caused by multiple diseases. This study examined the distribution of curative care expenditure (CCE) of medical institutions in Beijing using beneficiary characteristics such as residency, gender, age, and disease. Suggestions are presented for the development of health policies.

Methods

A total of 81 medical institutions with approximately 80 million patients in Beijing, China, were selected via a multistage stratified cluster random sampling approach. Based on this sample, the System of Health Accounts 2011 was used to estimate the CCE of medical institutions.

Results

The CCE of medical institutions in Beijing was ¥246.93 billion in 2019. The consumption of patients from other provinces was ¥60.04 billion, accounting for 24.13% of the total CCE. The CCE of female consumption (52.01%/¥128.42 billion) exceeded that of male consumption (47.99%/¥118.51 billion). Almost half of the CCE (45.62%/¥112.64 billion) was consumed by patients aged 60 or above. Adolescent patients up to an age of 14 (including those aged 14) mainly chose secondary or tertiary hospitals for treatment. Chronic non-communicable diseases accounted for the largest share of CCE consumption, with circulatory diseases accounting for the highest proportion.

Conclusions

This study identified significant differences in CCE consumption in Beijing according to region, gender, age, and disease. Currently, the utilization of resources in medical institutions is not reasonable, and the hierarchical medical system is not sufficiently effective. Therefore, the government needs to optimize the allocation of resources according to the needs of different groups and rationalize the institutional process and functions.
A bispecific antibody AP203 targeting PD-L1 and CD137 exerts potent antitumor activity without toxicity
Authors: Huang Po-Lin , Kan Hung-Tsai , Hsu Ching-Hsuan , Hsieh Hsin-Ta , Cheng Wan-Chien , Huang Ren-Yeong , You Jhong-Jhe
Published: May 2023

Background

Bispecific antibody has garnered considerable attention in the recent years due to its impressive preliminary efficacy in hematological malignancies. For solid tumors, however, the main hindrance is the suppressive tumor microenvironment, which effectively impedes the activation of infiltrating T cells. Herein, we designed a bispecific antibody AP203 with high binding affinity to PD-L1 and CD137 and assessed its safety and anti-tumor efficacy, as well as explored the mechanism of action.

Methods

The optimal antibody binders against PD-L1 and CD137 were screened from the OmniMab phagemid library. The binding affinity of the constructed AP203 were evaluated using enzyme-linked immunosorbent assay (ELISA) and biolayer interferometry (BLI). T-cell stimulatory capacity was assessed using the allogeneic mixed lymphocyte reaction (MLR), antigen-specific recall response, and coculture with PD-L1-expressing cells. In vivo antitumor efficacy was evaluated using two models of tumor-xenografted humanized mice with profiling of tumor infiltrating lymphocytes (TILs). The possible toxicity of AP203 was examined using in vitro cytokine release assay by human PBMCs.

Results

AP203, which simultaneously targeted PD-L1 and costimulatory CD137, elicit superior agonistic effects over parental antibodies alone or in combination in terms of T cell activation, enhanced memory recall responses, and overcoming Treg-mediated immunosuppression (P < 0.05). The agonistic activity of AP203 was further demonstrated PD-L1-dependent by coculturing T cells with PD-L1-expressing cells. In vivo animal studies using immunodeficient or immunocompetent mice both showed a dose-related antitumor efficacy superior to parental antibodies in combination (P < 0.05). Correspondingly, AP203 significantly increased tumor infiltrating CD8 + T cells, while decreased CD4 + T cells, as well as Treg cells (P < 0.05), resulting in a dose-dependent increase in the CD8 + /CD4 + ratio. Moreover, either soluble or immobilized AP203 did not induce the production of inflammatory cytokines by human PBMCs.

Conclusions

AP203 exerts potent antitumor activity not only by blocking PD-1/PD-L1 inhibitory signaling, but also by activating CD137 costimulatory signaling in effector T cells that consequently counteracts Treg-mediated immunosuppression. Based on promising preclinical results, AP203 should be a suitable candidate for clinical treatment of solid tumors.
Genotyping of dengue virus from infected tissue samples embedded in paraffin
Authors: Rivera Jorge Alonso , Rengifo Aura Caterine , Rosales-Munar Alicia , Díaz-Herrera Taylor H. , Ciro José Usme , Parra Edgar , Alvarez-Díaz Diego A. , Laiton-Donato Katherine , Caldas María Leonor
Published: May 2023

Dengue has become one of the vector-borne diseases that affect humans worldwide. In Latin American countries, Colombia is historically one of the most affected by epidemics of this flavivirus. The underreporting of signs and symptoms of probable cases of dengue, the lack of characterization of the serotypes of the infection, and the few detailed studies of postmortem necropsies of patients are among other conditions that have delayed progress in the knowledge of the pathogenesis of the disease. This study presents the results of fragment sequencing assays on paraffin-embedded tissue samples from fatal DENV cases during the 2010 epidemic in Colombia. We found that the predominant serotype was DENV-2, with the Asian/American genotype of lineages 1 and 2. This work is one of the few reports of the circulating genotypes of dengue during the 2010 epidemic in Colombia, one of the most lethal dates in the country's history.
Incremental value of enhanced plaque length for identifying intracranial atherosclerotic culprit plaques: a high-resolution magnetic resonance imaging study
Authors: Cheng XiaoQing , Liu Jia , Li HongXia , Yang JiaLuo , Zhou ChangSheng , Zhi BeiBei , Liu QuanHui , Li YingLe , Xiao LuLu , Zhu WuSheng , Lu GuangMing
Published: May 2023

Objectives

Besides plaque enhancement grade, the incremental value of enhancement-related high-resolution MRI features in defining culprit plaques needs further evaluation. This study was focused on assessing whether plaque enhancement features contribute to culprit plaque identification and further risk stratification.

Methods

We retrospectively studied patients who experienced an acute ischaemic stroke and transient ischaemic attack due to intracranial atherosclerosis from 2016 to 2022. The enhancement features included enhancement grade, enhanced length, and enhancement quadrant. Associations between plaque enhancement features and culprit plaques, as well as diagnostic value, were investigated using logistic regression and receiver operating characteristic analyses.

Results

Overall, 287 plaques were identified, of which 231 (80.5%) and 56 (19.5%) were classified as culprit and non-culprit plaques, respectively. Comparison of the pre- and post-enhancement images revealed enhanced length longer than the plaque length in 46.32% of the culprit plaques. Multivariate logistic regression showed that enhanced length longer than plaque length (OR 6.77; 95% CI 2.47–18.51) and grade II enhancement (OR 7.00; 95% CI 1.69–28.93) were independently associated with culprit plaques. The area under the curve value for the combination of stenosis and plaque enhancement grade for the diagnosis of culprit plaques was 0.787, which increased significantly to 0.825 on the addition of enhanced length longer than the plaque length (p = 0.026 for DeLong’s test).

Conclusions

Enhanced length longer than the plaque length and grade II enhancement were independently associated with culprit plaques. The combination of the enhanced plaque features resulted in better culprit plaque identification.
DLA-E: a deep learning accelerator for endoscopic images classification
Authors: Bolhasani Hamidreza , Jassbi Somayyeh Jafarali , Sharifi Arash
Published: May 2023

The super power of deep learning in image classification problems have become very popular and applicable in many areas like medical sciences. Some of the medical applications are real-time and may be implemented in embedded devices. In these cases, achieving the highest level of accuracy is not the only concern. Computation runtime and power consumption are also considered as the most important performance indicators. These parameters are mainly evaluated in hardware design phase. In this research, an energy efficient deep learning accelerator for endoscopic images classification (DLA-E) is proposed. This accelerator can be implemented in the future endoscopic imaging equipments for helping medical specialists during endoscopy or colonoscopy in order of making faster and more accurate decisions. The proposed DLA-E consists of 256 processing elements with 1000 bps network on chip bandwidth. Based on the simulation results of this research, the best dataflow for this accelerator based on MobileNet v2 is kcp_ws from the weight stationary (WS) family. Total energy consumption and total runtime of this accelerator on the investigated dataset is 4.56 × 109 MAC (multiplier–accumulator) energy and 1.73 × 107 cycles respectively, which is the best result in comparison to other combinations of CNNs and dataflows.
Video assisted thoracoscopic surgery vs thoracotomy in management of post traumatic retained hemothorax: a randomized study
Authors: Khalaf Abd Elrahman Mohammed , Ghoneim Ahmed Emadeldeen , Mahmoud Alaa Basiouni , Abdelwahab Amr Abdelmonem
Published: May 2023

Background

Retained hemothorax is a serious problem that can lead to empyema or fibro-thorax. Evacuation of the retained hemothorax is commonly performed via open thoracotomy. This randomized study was conducted to represent our center's expertise with this issue, we compared the outcomes of video-assisted thoracoscopic surgery (VATS) against open thoracotomy in managing post-traumatic retained clotted hemothorax.

Methods

This prospective randomized research was conducted on sixty cases with posttraumatic remaining clots of at least 500 ml or at least one-third of haemothorax that cannot be evacuated by a chest tube after 72 h of first intervention, as detected by computed tomography imaging who underwent open thoracotomy or VATS in the management of posttraumatic retained clotted hemothorax. Cases were allocated to equal groups; group A: cases who underwent VATS and group B: cases who underwent open thoracotomy.

Results

Preoperative intercostal chest tube (ICT) placement period was insignificantly different between the two groups. Group A had a significantly lesser post-operative amount of ICT drainage, and ICT was removed after significantly fewer days than in group B (P value < 0.001). Post-operatively, the numerical rating scale (NRS) was significantly higher at post-extubation and 6 h after extubation in group B than group A (P value < 0.05) and was insignificantly different between both groups the next morning, after chest tube removal and before discharge. group A had statistically better NRS versus group B (P value < 0.001). Wound infection incidence was significantly less in group A compared to group B (P value = 0.025); the incidence of air leak was insignificantly different between both groups. Group A has significantly shorter hospitalization than group B (P value < 0.001). Wound infection and empyema in outcases were insignificantly different between both groups (P value = 0.492). Cases in group A returned to normal activity earlier than group B (P value < 0.001).

Conclusions

VATS in managing posttraumatic retained hemothorax was a more effective, well-tolerated, and reliable intervention that can be easily utilized for managing posttraumatic retained hemothorax in comparison to open thoracotomy.
Management of suicide and self-harm risk by the National Mental Health Helpline in the State of Qatar
Authors: Alabdulla Majid , Iqbal Yousaf , Mohamed Hadeel Gafar Ali , Shinith Dhanya , Buenaventura Rodel Austria , Smith Katja Anneli Warwick , Hamideh Mohamed , Ouanes Sami
Published: May 2023

Background

Suicide is a serious public health problem.

Aims

To investigate the sociodemographic and clinical features of callers (patients) classed by the Qatar National Mental Health Helpline (NMHH) as moderate to high priority based on the risk of self-harm or suicide during the COVID-19 pandemic.

Method

The study design was a retrospective chart review of patients who contacted the helpline in the first 12 months, starting 1 April 2020. Data of those classed as moderate to high priority based on risk to self were collected using a specifically designed form. Absolute and relative frequencies for each of the studied categorical variables were determined.

Results

Four hundred and ninety-eight patients were included. More than half were female. The mean age was 32 years (range 8–85 years). Two-thirds of patients were from Arab countries and more than half of all patients had contacted mental health services for the first time. The most common symptoms elicited included suicidal thoughts, depressed mood and disturbed sleep. The most common psychiatric disorders were depression and generalised anxiety disorder. Most patients were seen within 4 h and received psychiatric interventions. Virtually all patients received non-pharmacological interventions; only 38.5% received pharmacological interventions. The majority had follow-up appointments arranged with mental health services.

Conclusions

People from the Indian subcontinent and males proportionally approached services less, which may reflect stigma. The NMHH improved access to care for patients considered at risk to self and prevented hospital admissions. The NMHH offers a valuable additional choice to patients and assists in prevention and management of suicidal behaviour and other mental health difficulties.
Antibody-Drug Conjugates in Gynecologic Cancer
Authors: Karpel Hannah C. , Powell Sachia Stonefeld , Pothuri Bhavana
Published: May 2023

The present article reviews the current evidence for antibody-drug conjugates (ADCs) in gynecologic cancer. ADCs consist of a highly selective monoclonal antibody for a tumor-associated antigen and a potent cytotoxic payload conjugated through a linker. Overall, the toxicity profiles of ADCs are manageable. Ocular toxicity is a known class effect of some ADCs and is managed with prophylactic corticosteroid and vasoconstrictor eye drops as well as dose interruptions/holds and dose modifications. In ovarian cancer, mirvetuximab soravtansine, an ADC targeting alpha-folate receptor (FRα), received US Food and Drug Administration (FDA) accelerated approval in November 2022 after data from the single-arm phase III SORAYA trial. A second ADC targeting FRα, STRO-002, received FDA fast track designation in August 2021. Multiple studies with upifitamab rilsodotin, an ADC comprising a NaPi2B-binding antibody, are underway. In cervical cancer, tisotumab vedotin, an ADC-targeting tissue factor, received FDA accelerated approval in September 2021 after the phase II innovaTV 204 trial. Tisotumab vedotin in combination with chemotherapy and other targeted agents is currently being evaluated. Although there are no currently approved ADCs for endometrial cancer, there are many under active evaluation, including mirvetuximab soravtansine. Trastuzumab-deruxtecan (T-DXd), an ADC targeting human epidermal growth factor receptor 2 (HER2), is currently approved for HER2-positive and HER2-low breast cancer and shows promise in endometrial cancer. Like all anticancer treatments, the decision for a patient to undergo therapy with an ADC is a personal choice that balances the potential benefits with the side effects and requires thorough and compassionate support of their physician and care team and shared decision making.
Training to upskill staff to assess for psychosocial concerns and distress
Authors: Bevin Amanda
Published: May 2023

All renal staff should be trained in detecting the mental health and social needs of people with kidney disease
The role that food and diet play in living well with kidney disease
Authors: Duval Deborah
Published: May 2023

Kidney Care UK has created the Kidney Kitchen for those who do not have convenient access to a renal dietician. In light of this issue, Deborah Duval presents insights to share with patients looking to maintain their kidney health
Rethinking screening for diabetes
Authors: Ellis Peter
Published: May 2023

This article outlines a study suggesting that the cut-offs for diabetes screening based on body mass index may miss many prediabetic and diabetic individuals — a problem that applies to all racial groups and some other groups in particular
Multiply revised TKAs have worse outcomes compared to index revision TKAs
Authors: Roof Mackenzie A. , Lygrisse Katherine , Shichman Ittai , Marwin Scott E. , Meftah Morteza , Schwarzkopf Ran
Published: May 2023

Aims

Revision total knee arthroplasty (rTKA) is a technically challenging and costly procedure. It is well-documented that primary TKA (pTKA) have better survivorship than rTKA; however, we were unable to identify any studies explicitly investigating previous rTKA as a risk factor for failure following rTKA. The purpose of this study is to compare the outcomes following rTKA between patients undergoing index rTKA and those who had been previously revised.

Methods

This retrospective, observational study reviewed patients who underwent unilateral, aseptic rTKA at an academic orthopaedic speciality hospital between June 2011 and April 2020 with > one-year of follow-up. Patients were dichotomized based on whether this was their first revision procedure or not. Patient demographics, surgical factors, postoperative outcomes, and re-revision rates were compared between the groups.

Results

A total of 663 cases were identified (486 index rTKAs and 177 multiply revised TKAs). There were no differences in demographics, rTKA type, or indication for revision. Multiply revised patients had significantly longer rTKA operative times (p < 0.001), and were more likely to be discharged to an acute rehabilitation centre (6.2% vs 4.5%) or skilled nursing facility (29.9% vs 17.5%; p = 0.003). Patients who had been multiply revised were also significantly more likely to have subsequent reoperation (18.1% vs 9.5%; p = 0.004) and re-revision (27.1% vs 18.1%; p = 0.013). The number of previous revisions did not correlate with the number of subsequent reoperations (r = 0.038; p = 0.670) or re-revisions (r = −0.102; p = 0.251).

Conclusion

Multiply revised TKA had worse outcomes, with higher rates of facility discharge, longer operative times, and greater reoperation and re-revision rates compared to index rTKA.

Cite this article: Bone Jt Open 2023;4(5):393–398.
O ENSINO DO HANDEBOL NAS AULAS DE EDUCAÇÃO FÍSICA: UM ESTADO DA ARTE
Authors: Carvalho Dias Wendson , Pacheco Ramos Michael Daian , Oliveira Noberto da Silva Osni
Published: May 2023

O presente estudo analisa a produção científica relacionada ao tema Handebol na escola, especificamente, nas revistas de impacto na Educação Física sem restrição de período de tempo. Trata-se de um estudo de caráter bibliográfico denominado “estado da arte”. Foram encontrados 76 estudos obtidos por meio de pesquisa com o descritor “Handebol”, sendo analisados apenas 3 destes, voltados ao Handebol nas escolas. Conclui-se que o número de estudos voltados ao Handebol na escola é insuficiente, podendo ser este um dos obstáculos existentes para a consolidação dessa modalidade esportiva no âmbito escolar.
O PROFESSOR DE EDUCAÇÃO FÍSICA NO ENSINO MÉDIO E O TRATO COM O CONTEÚDO LUTAS: UMA REVISÃO BIBLIOGRÁFICA
Authors: Ribeiro Santos Nathalya , Silva Reis Jherlon , Lima Silva Micaele
Published: May 2023

O texto aqui apresentado trata-se de uma revisão bibliográfica referente ao conteúdo de Lutas no Ensino Médio e como o professor de Educação Física pode ensinar nesse espaço. Assim, busca responder como o professor de Educação Física trabalha o conteúdo Lutas no Ensino Médio, tendo como intenção construir um trabalho que embase o professor de EF a trabalhar tal conteúdo em sala de aula, como previsto na Base Nacional Comum Curricular e nos Parâmetros Curriculares Nacionais. Com base nos materiais analisados, concluiu-se que os jogos de combate se mostram mais eficazes para desenvolver essa temática nas aulas, e que o professor tem diversas possibilidades de intervenção e aproximações das Lutas com seus alunos, como vídeos, imagens, profissionais convidados, videogames e qualquer outra forma que possibilite ao professor aproximar seus alunos dessa forma individual da cultura corporal.
Tsuchime-like cost-efficient aluminum film to enhance absorption in thin and ultra-thin photovoltaic cells
Authors: Marus Mikita , Mukha Yauhen , Wong Him-Ting , Chan Tak-Lam , Smirnov Aliaksandr , Hubarevich Aliaksandr , Hu Haibo
Published: May 2023

Silicon solar cells account for more than ninety percent of the photovoltaic (PV) market, primarily due to convenience, cost-effectiveness, and long service life. However, the light absorption efficiency of PV cells remains a limiting factor, especially for thin and ultra-thin solar panels. Most methods for increasing light absorption in thin and ultra-thin solar cells are either cost-ineffective or technically challenging, given the thinness of the functional layers employed. In this article, we propose employing a lithography-free and cost-efficient approach to increase the light absorption in thin and ultra-thin solar cells using a Tsuchime-like self-forming nanocrater (T-NC) aluminum (Al) film. T-NC Al film can be obtained by the well-known process of electrochemical anodizing of Al followed by etching the nanoporous alumina (Al2O3). According to the current study, T-NC film boosts the average absorbance in the 400-1100 nm wavelength range by 85.9, 64.3, 46.3 and 41.8% for PV cells with silicon active layer thickness of 500 nm, 1 µm, 3 µm, and 10 µm, respectively. Moreover, the wavelength range of increased absorption depends on silicon thickness, where the peak of absolute increase of absorbance moves from 620 nm to 950 nm as the thickness of the silicon layer increases from 500 nm to 10 µm. Therefore, T-NC Al film allows for a significant increase in the efficiency of thin and ultra-thin solar cells without involving costly top-down techniques such as lithography.
Physical activity and mental health during the COVID-19 pandemic among individuals with amputation
Authors: Leister Kyle R. , Heffernan Kevin , Miller Taavy , Barreira Tiago
Published: May 2023

The isolating nature of various COVID-19 mandates may have reduced physical activity (PA) and increased mental health symptomology among individuals with amputation. However, an investigation of mental health across PA levels before and after the onset of COVID-19 among this group has not been conducted. Therefore, the objective of this study was to investigate group differences in depression, anxiety, and post-traumatic stress symptomology among individuals with amputation who reported being physically “active,” “somewhat active,” or “inactivate” before and during the pandemic. Individuals with an amputation at any level (n = 91; 51% female; age = 52.5±15.5) completed an online questionnaire to assess demographic information, PA levels, and mental health throughout the pandemic. Group differences in self-reported PA before and after COVID-19 onset were assessed by the PA Guidelines for Americans recommendations. The Center for Epidemiologic Studies Depression Scale (CES-D), Generalized Anxiety Disorder (GAD-7), and Posttraumatic Stress Disorder Checklist (PCL-5) scales were used to assess group differences in mental health status. Before and after the onset of COVID-19, 33% and 42.9% of respondents reported that they were inactive, respectively. 58.2% of respondents reported decreased PA since the pandemic’s onset. Prior to the pandemic, active individuals reported lower CES-D (14.21 vs. 19.07; Cohen’s d: -0.414), GAD-7 (3.82 vs. 5.47; Cohen’s d: -0.359), and PCL-5 (15.92 vs. 21.03; Cohen’s d: -0.319) scores compared to inactive individuals. After the onset of COVID-19, scores remained lower for active respondents CES-D (12.67 vs. 20.03; Cohen’s d: 0.-669), GAD-7 (3.17 vs. 5.87; Cohen’s d: -0.598), and PCL-5 (13.39 vs. 19.90; Cohen’s d: -0.430). Individuals with amputation reported decreased PA after the onset of COVID-19. Individuals reporting that they were “active” exhibited improved depression and anxiety symptomology scores compared to those reporting that they were “inactive.”
A study of the impact of corporate digitization on environmental protection: Take Chinese A-share companies in Shanghai and Shenzhen as an example
Authors: Zhao Zexia , Yan Jun
Published: May 2023

Textual analysis and the Entropy-TOPSIS method are used in this research to create a measure of corporate environmental protection, and multiple regressions are used to find out how digitalization affects corporate environmental protection. The research sets up a theoretical framework for how corporate digitalization affects environmental protection and looks into how external financing constraints and an organization’s own financial position play a role in the middle. The research then looks at how outside factors like the business environment of the market and the level of competition in the industry affect the relationship. Using a threshold regression approach, the research also examines the change in the impact of digitalization on environmental protection after investor sentiment crosses the threshold from the distinct perspective of investor sentiment. Our research provides theoretical support for environmental protection by corporations and government policy direction.
Evidence on the links between water insecurity, inadequate sanitation and mental health: A systematic review and meta-analysis
Authors: Kimutai Joan J. , Lund Crick , Moturi Wilkister N. , Shewangizaw Seble , Feyasa Merga , Hanlon Charlotte
Published: May 2023

Background

Water insecurity and inadequate sanitation have adverse impacts on the mental health of individuals.

Objective

To review and synthesize evidence on the relationship between water insecurity, inadequate sanitation, and mental health globally.

Data sources

Relevant studies were identified by searching PubMed, PsycINFO, and EMBASE databases from inception up to March 2023.

Study eligibility criteria

Only quantitative studies were included. The exposure was water insecurity and or inadequate sanitation. The outcome was common mental disorders (CMD: depression or anxiety), mental distress, mental health or well-being. There was no restriction on geographical location.

Participants

General population or people attending health facilities or other services.

Exposure

Water insecurity and/ or inadequate sanitation.

Risk of bias

The effective Public Health Practice Project (EPHPP) assessment tool was used to assess quality of selected studies.

Synthesis of results

A meta-analysis was conducted using a random effects statistical model.

Results

Twenty-five studies were included, with 23,103 participants from 16 countries in three continents: Africa (Kenya, Ethiopia, Ghana, Uganda, South Africa, Malawi, Mozambique, and Lesotho), Asia (Nepal, Bangladesh, India, and Iran) and the Americas (Brazil, Haiti, Bolivia and Vietnam). There was a statistically significant association between water insecurity and CMD symptoms. Nine studies reported a continuous outcome (5,248 participants): overall standardized mean difference (SMD = 1.38; 95% CI = 0.88, 1.87). Five studies reported a binary outcome (5,776 participants): odds ratio 5.03; 95% CI = 2.26, 11.18. There was a statistically significant association between inadequate sanitation and CMD symptoms (7415 participants), overall SMD = 5.36; 95% CI = 2.51, 8.20.

Limitations

Most of the included studies were cross-sectional which were unable to examine temporal relationships.

Conclusions

Water insecurity and inadequate sanitation contribute to poorer mental health globally.

Implications of key findings

Interventions to provide basic water, sanitation and psychosocial support, could substantially contribute to reducing the burden of CMD alongside other health and social benefits.

Trial registration

PROSPERO registration number: CRD42022322528.
Children’s suggestibility for neutral arbitrary actions in the context of norm violations
Authors: Vaporova Elena , Zmyj Norbert
Published: May 2023

This study investigated children’s false memories for neutral arbitrary actions. Five- to six-year-olds (N = 32) were taught four arbitrary actions, each following specific rules. The children then watched a televised adult performing eight actions: the four familiar actions while violating one aspect of each rule script and four unfamiliar actions. Suggestive and non-suggestive questions about all witnessed actions were asked, followed by forced-choice test questions to measure the false memory effect. The likelihood of forming false memories was higher in the suggestive condition than in the non-suggestive condition. There was no effect of previously acquired knowledge about the rules of the actions and no interaction between rule knowledge and suggestion. The results are discussed in light of previous findings in related fields of false memory research.
Development and characterization of a copolymeric micelle containing soluble and insoluble model drugs
Authors: Mohammadi Farhad , Moradi Alireza , Tavakoli Fatemeh , Rahmati Samaneh , Giti Rashin , Ramezani Vahid
Published: May 2023

Objectives

Micelles are nano-sized particles with a core-shell structure that are made by natural or synthetic polymers or copolymers. The aim of this study was to develop and characterize a copolymeric micelle using two polymers loaded with hydrophilic and lipophilic drugs.

Methods

Poly(ethylene glycol) and poly(ε-caprolactone) (PEG-PCL) were used to form a copolymeric micelle which was further loaded with either moxifloxacin or clarithromycin as hydrophilic and lipophilic drug samples, respectively. Characterization tests were done including fourier transform-infrared (FT-IR) spectroscopy, proton nuclear magnetic resonance (1H NMR) spectroscopy, encapsulation efficiency, particle size, zeta potential, polydispersity index, transmission electron microscopy, and in-vitro release test.

Results

The construction of the copolymer was confirmed by the results of FT-IR and 1H NMR spectroscopy tests. The encapsulation efficiency test exhibited that loading was about 50% for twelve formulations. Particle size, zeta potential, polydispersity index, and transmission electron microscopy confirmed the formation of monodispersed, uniform, and nano-sized micelles with a few negative charges. The kinetic model of release was fitted to the Higuchi model.

Conclusions

Polymeric micelles consisting of PEG-PCL copolymer were loaded with adequate concentrations of hydrophilic (moxifloxacin) and lipophilic (clarithromycin) model drugs, with a mean particle size under 300 nm. Therefore, copolymeric micelles can be used as a suitable drug delivery system for mucous membranes and skin.
Predictors of discharge to home/community following inpatient-rehabilitation in a US national sample of Guillain-Barre-Syndrome patients
Authors: Kushner David S. , Johnson-Greene Doug , Felix Elizabeth R. , Miller Cheryl , Cordero Maite K. , Thomashaw Stacy A.
Published: May 2023

Background

Guillain-Barre-Syndrome (GBS), an autoimmune polyneuropathy causing acute flaccid paralysis, is a rare condition with1-2 cases per 100,000 annually (approximately 5000 cases/year) in the United States (US). There is a paucity of published data regarding patient outcomes in association with discharge destinations following inpatient-rehabilitation (IR) in this patient population, thus this study.

Objectives

To analyze IR efficacy, and possible predictors of discharge to home/community in a US-national-sample of GBS patients.

Methods

Retrospective-observational-cohort study of 1304 GBS patients admitted to IR comparing discharge disposition destinations (community/home, skilled-nursing-facility [SNF], or return to acute-care) by demographic (age, gender) and clinical variables (length-of-stay [LOS], case-mix-index [CMI], and Functional-Independence-Measure [FIM] score changes). Multinomial-logistic-regression and discriminant-function-analysis were performed to determine model fit in predicting discharge destination.

Results

81.8% were discharged to home/community- average LOS 19-days, total-FIM-gain 43.2; 9.8% discharged to SNFs- average LOS 27.5-days, total-FIM-gain 27.2; and 8.4% discharged to acute-care- average LOS 15.4-days and total-FIM-gain 16.5, (F = 176, p < .001). Stepwise-linear-regression for prediction of community discharge showed change in FIM-Bed/chair/wheelchair-Transfers was the most significant predictor (Wald = 42.2; p < .001), followed by CMI (Wald = 26.9; p < .001), change in FIM-walking/wheelchair (Wald = 14.9; p < .001), and age (Wald = 9.5; p < .002). Using discriminant-function-analysis to test model validity for predicting discharge disposition, FIM-change for Bed/chair/wheelchair Transfers, Walking, and Self-Care as predictors resulted in a classification rate of 78.1%, 92% of variance explained, and Eigenvalue of .53 (p < .001).

Conclusions

Total-FIM scores improved in all groups, and most patients were discharged to home/community suggesting IR efficacy. The ability to transfer bed/chair/wheelchair was the most important predictive factor associated with discharge destination.
The analysis of infrared high-speed motion capture system on motion aesthetics of aerobics athletes under biomechanics analysis
Authors: Qiu Yaoyu , Guan Yingrong , Liu Shuang
Published: May 2023

This paper uses an infrared high-speed motion capture system based on deep learning to analyze difficult movements, which helps aerobics athletes master difficult movements more accurately. Firstly, changes in joint angle, speed of movement, and ground pressure are used to analyze the impact and role of motion fluency and completion based on a biomechanical perspective. Moreover, based on the existing infrared high-speed motion capture systems, the Restricted Boltzmann Machine (RBM) model is introduced to construct an unsupervised similarity framework model. Next, the motion data is reorganized based on three-dimensional information to adapt to the model’s input. Then, the framework performs similar frame matching to obtain a set of candidate frames that can be used as motion graph nodes. After the infrared high-speed motion capture system and inertial sensors are simultaneously applied to subjects, the multi-correlation coefficients (CMC) values of the hip, knee, and ankle angles are 0.94 ± 0.06, 0.98 ± 0.01, and 0.87 ± 0.09, respectively. The two systems show a high degree of correlation in the measurement results, and the knee joint is the most significant correlation. Finally, a motion graph is constructed to control its trajectory and adjust its motion pattern. The infrared high-speed motion capture system optimized for deep learning can extract features from human bone data and capture motion more accurately, helping trainers to fully understand difficult movements.