bluuebunny/crossref_metadata_2025 huggingface dataset:
Effects of Heart Rate Variability Coherence Biofeedback Training and Emotional Management Techniques to Decrease Music Performance Anxiety
Authors: Thurber Myron R. , Bodenhamer-Davis Eugenia , Johnson Mark , Chesky Kris , Chandler Cynthia K.
Published: December 2010

Due to the prevalence of music performance anxiety and the emergence of new biofeedback technologies used to decrease anxiety, student musicians were recruited to participate in an experimental repeated-measures study to identify effects of heart rate variability coherence biofeedback training and emotional self-regulation techniques on music performance anxiety and music performance. Fourteen students were assigned randomly to a treatment or control group following a 5-minute unaccompanied baseline performance. Treatment group participants received 4–5 heart rate variability training sessions of 30–50 minutes each. Training included bibliotherapy, computerized heart rate variability biofeedback training, emotional regulation exercises, and use of a portable heart rate variability training device. Measures included the State-Trait Anxiety Inventory, Performance Anxiety Inventory, Flow State Scale, average heart rate, and heart rate variability. Quade's rank-transformed analysis of covariance was used to evaluate treatment and no-treatment group comparisons. Combined music performance anxiety scores showed statistically significant improvement at a p  =  .05 level with a large effect size of ηp2  =  .320. State anxiety measurement showed a large effect size of ηp2  =  .291. The Performance Anxiety Inventory showed a large effect size of ηp2  =  .149. Heart rate showed a large effect size of ηp2  =  .143. Heart rate variability showed statistical significance at p  =  .001 level and a large effect size of ηp2  = .698. The treatment group average subjective decrease in music performance anxiety was 71%, and the treatment group average subjective improvement in performance was 62%. This study demonstrated statistical and practical/clinical significance of a relatively quick and inexpensive biofeedback training that had a large effect on decreasing mental, emotional, and physiological aspects of music performance anxiety and subjective improvement of performance for university students.
Arousal and Identity: Thoughts on Neurofeedback in Treatment of Developmental Trauma
Authors: Fisher Sebern F.
Published: December 2010

This article addresses the issue of arousal in developmental trauma. The article suggests that emotional disturbance can be seen as a disruption in rhythmic regulation. The author presents a treatment approach that emphasizes training the regulation of emotional arousal and discusses the impact of this approach on identity in this population. The major affect of concern is fear, and the primary goal of neurofeedback is seen as the reduction of fear and reactivity. The article attempts to elucidate the clinical challenges confronted when this is accomplished.
Neal E. Miller and His Research1
Authors: Coons Edgar E. , Leibowitz Sarah F.
Published: December 2010

Neal Miller's research contributions mainly concerned reward and learning mechanisms: (a) underlying thought processes and behaviors relevant to problem solving in psychotherapy and everyday life, (b) as mediated by the nervous system, and (c) involved in learning control over voluntary (conscious) skeletal muscle and autonomic (normally unconscious) internal-organ response systems for minimizing stress, treating disease, and promoting health. His career shows psychology's evolution from a theory-driven but data-impoverished discipline in the 1930s to one integrating vast bodies of clinical, social, and physiological knowledge.
What Psychology as a Science Owes Neal Miller: The Example of His Biofeedback Research
Authors: Taub Edward
Published: December 2010

Neal Miller did more to make psychology a science than any other investigator. His importance does not lie with any specific discoveries that he made, but rather with his way of doing scientific research, which involved pursuing a line of logic systematically through sequences of experiments, and paying attention to several alternate hypotheses that could answer each of the experimental questions addressed. His approach was a model of what has been called “Strong Inference” and that is characteristically used in the hard sciences. His biofeedback research is used as a case history of his method of approach.
Testimonial for and Reminiscences about Neal Miller
Authors: Bower Gordon H.
Published: December 2010

The author served as a research assistant with Neal Miller at Yale from 1955 to 1959. He narrates Miller's research activities on social learning and imitation, on personality and psychotherapy, and on brain structures mediating biological drives and rewards. He describes Miller's classroom teaching and relationships with graduate students. He pays tribute to Miller's encouragement for Bower's own research, and the life lessons and scientific lessons he provided for many of his students and young researchers.
Neal Miller and the Integration of Psychoanalysis and Behavior Therapy
Authors: Wachtel Paul L.
Published: December 2010

Neal Miller's pioneering insights into the possibilities of synthesis between psychoanalytic and learning theory formulations of phenomena of anxiety, defense, psychopathology, and personality dynamics provided a key foundation for later efforts to integrate psychodynamic and cognitive-behavioral approaches to therapy. This paper highlights Miller's influence and the continuing legacy of his integrative mindset in the contemporary psychotherapy integration movement.
Coagulation and inflammation
Authors: Lipinski S. , Bremer L. , Lammers T. , Thieme F. , Schreiber S. , Rosenstiel P.
Published: December 2010

Overwhelming evidence has linked inflammatory disorders to a hypercoagulable state. In fact, thromboembolic complications are among the leading causes of disability and death in many acute and chronic inflammatory diseases. Despite this clinical knowledge, coagulation and immunity were long regarded as separate entities. Recent studies have unveiled molecular underpinnings of the intimate interconnection between both systems. The studies have clearly shown that distinct pro-inflammatory stimuli also activate the clotting cascade and that coagulation in turn modulates inflammatory signaling pathways.

In this review, we use evidence from sepsis and inflammatory bowel diseases as a paradigm for acute and chronic inflammatory states in general and rise hypotheses how a systematic molecular understanding of the “inflammation-coagulation” crosstalk may result in novel diagnostic and therapeutic strategies that target the inflammation-induced hypercoagulable state.
Synthesis of Peptidomimetic Conjugates of Cyclic Nucleoside Phosphonates
Authors: Serpi Michaela , Krylov Ivan S. , Zakharova Valeria M. , McKenna Charles E.
Published: December 2010

Cyclic nucleoside phosphonates connected through a P‐O‐C linkage to a promoiety represent a class of prodrugs designed to overcome the low oral bioavailability of parent antiviral acyclic nucleoside phosphonates. In our prodrug approach, a nontoxic promoiety, such as an amino acid or dipeptide, is conjugated to the cyclic form of the parent drug by esterification of the phosphonic acid moiety with an alcoholic amino acid side chain (Ser, Tyr, and Thr) or a glycol linker. For the biological evaluation and investigation of the pharmacokinetic profiles of these modified nucleoside phosphonates, a reliable synthetic procedure that allows preparation of sufficient amount of potential prodrugs is needed. This unit provides a procedure for synthesizing peptidomimetic conjugates of two broad‐spectrum antiviral acyclic nucleoside phosphonates: (S)‐HPMPC and (S)‐HPMPA. Two alternate strategies allowing synthesizing selected amino acid, dipeptide, or ethylene glycol‐linked amino acid prodrugs of (S)‐HPMPC and (S)‐HPMPA in solution and using a solid‐phase approach are presented. Curr. Protoc. Nucleic Acid Chem. 43:15.4.1‐15.4.13. © 2010 by John Wiley & Sons, Inc.
Purification of Ribosomes from Human Cell Lines
Authors: Belin Stéphane , Hacot Sabine , Daudignon Lionel , Therizols Gabriel , Pourpe Stéphane , Mertani Hichem C. , Rosa‐Calatrava Manuel , Diaz Jean‐Jacques
Published: December 2010

Highly conserved during evolution, the ribosome is the central effector of protein synthesis. In mammalian cells, the ribosome is a macromolecular complex composed of four different ribosomal RNAs (rRNA) and about 80 ribosomal proteins. Requiring more than 200 factors, ribosome biogenesis is a highly complex process that takes place mainly within the nucleoli of eukaryotic cells. Crystallographic data suggest that the ribosome is a ribozyme, in which the rRNA catalyses the peptide bond formation and ensures quality control of the translation. Ribosomal proteins are involved in this molecular mechanism; nonetheless, their role is still not fully characterized. Recent studies suggest that ribosomes themselves and/or the mechanisms underlying their synthesis, processing, and assembly play a key role in the establishment and progression of several human pathologies. The protocol described here is simple, efficient, and robust, and allows one to purify high‐quality ribosomes from human cultured cell lines. Ribosomes purified with this protocol are adequate for most of the subsequent analyses of their RNA and protein content. Curr. Protoc. Cell Biol. 49:3.40.1‐3.40.11. © 2010 by John Wiley & Sons, Inc.
Gene Down‐Regulation with Short Hairpin RNAs and Validation of Specificity by Inducible Rescue in Mammalian Cells
Authors: Ma Hoi Tang , Poon Randy Y.C.
Published: December 2010

The principal problem with RNA interference (RNAi) experiments is off‐target effects. The most vigorous demonstration of the specificity is the rescue of the RNAi effects with an RNAi‐resistant target gene. By combining the expression of short hairpin RNA (shRNA) and rescue cDNA in the same vector, both the validation of shRNA specificity and the generation of shRNA‐expressing cell lines can easily be accomplished. If the compensatory cDNA is under the control of an inducible promoter, stable shRNA‐expressing cells can be generated before the knockdown phenotypes are studied, by conditionally turning off the rescue protein. The use of model systems is detailed in these protocols. Curr. Protoc. Cell Biol. 49:27.2.1‐27.2.12. © 2010 by John Wiley & Sons, Inc.
Mechanically Durable Superhydrophobic Surfaces
Authors: Verho Tuukka , Bower Chris , Andrew Piers , Franssila Sami , Ikkala Olli , Ras Robin H. A.
Published: December 2010

Development of durable non‐wetting surfaces is hindered by the fragility of the microscopic roughness features that are necessary for superhydrophobicity. Mechanical wear on superhydrophobic surfaces usually shows as increased sticking of water, leading to loss of non‐wettability. Increased wear resistance has been demonstrated by exploiting hierarchical roughness where nanoscale roughness is protected to some degree by large scale features, and avoiding the use of hydrophilic bulk materials is shown to help prevent the formation of hydrophilic defects as a result of wear. Additionally, self‐healing hydrophobic layers and roughness patterns have been suggested and demonstrated. Nevertheless, mechanical contact not only causes damage to roughness patterns but also surface contamination, which shortens the lifetime of superhydrophobic surfaces in spite of the self‐cleaning effect. The use of photocatalytic effect and reduced electric resistance have been suggested to prevent the accumulation of surface contaminants. Resistance to organic contaminants is more challenging, however, oleophobic surface patterns which are non‐wetting to organic liquids have been demonstrated. While the fragility of superhydrophobic surfaces currently limits their applicability, development of mechanically durable surfaces will enable a wide range of new applications in the future.
The phenotype caused by PYCR1 mutations corresponds to geroderma osteodysplasticum rather than autosomal recessive cutis laxa type 2
Authors: Yıldırım Yeşerin , Tolun Aslıhan , Tüysüz Beyhan
Published: December 2010

Geroderma osteodysplasticum is a rare autosomal recessive disorder characterized by wrinkled skin on the dorsum of the hands and feet, osteopenia, prognathism, and an elongated and lax face. The mutated gene was identified as GORAB (SCYL1BP1). As well, the PYCR1 gene also was shown to be mutated in a similar disease, designated cutis laxa, autosomal recessive, type IIB (ARCL2B) or cutis laxa with progeroid features. We describe here the clinical findings in four affected individuals in a family with geroderma osteodysplasticum with mental retardation and a homozygous mutation in PYCR1. Although the disease resulting from recessive mutations in that gene has been recently designated ARCL2B, some clinical features, such as prognathism, elongated and lax face, osteopenia and limitation of skin wrinkling to the dorsum of hands and feet, in the patients reported here as well as in others reported with PYCR1 mutations, are generally more common in geroderma osteodysplasticum resulting from recessive GORAB mutations. While the patients with GORAB mutations have severe osteopenia, the patients with PYCR1 mutations have severe mental retardation. In conclusion, the phenotype caused by PYCR1 mutations corresponds to geroderma osteodysplasticum rather than ARCL2B. © 2010 Wiley‐Liss, Inc.
Preparation and characterization of UV‐curable, boron‐containing, transparent hybrid coatings
Authors: Mülazim Yusuf , Kahraman Memet Vezir , Apohan, Nilhan Kayaman , Kızıltaş Sahip , Güngör Atilla
Published: December 2010

A series of ultraviolet (UV)‐curable, boron‐containing hybrid coatings were prepared by an anhydrous sol–gel technique from a mixture of an acrylated bisphenol A based epoxy resin, methacryloxymethyl triethoxysilane, and boric acid. The use of boric acid allowed the hydrolysis and condensation of hybrid silicon alkoxides without the further addition of water or a catalyst. The chemical structure of the boron‐containing hybrid coatings was characterized with Fourier transform infrared, real‐time infrared, and 29Si cross‐polarization/magic‐angle spinning NMR techniques. UV‐curable coatings were applied to polycarbonate and Plexiglas substrates. The physical and mechanical properties of the UV‐cured coatings (e.g., pendulum hardness, pencil hardness, contact angle, gel content, methyl ethyl ketone rubbing test, tensile test, abrasion resistance, chemical resistance, neutron absorption, and limiting oxygen index) were examined. The hybrid coatings showed a significant enhancement in their radiation‐shielding properties. The thermal behavior of the coatings was also evaluated. It was observed that the thermal stability of the coatings mainly depended on their boron and silicate contents. The results of all analyses of the free films and coatings were examined. © 2010 Wiley Periodicals, © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2011
Dendrimer finishing influence on CO/PES blended fabrics color assessment
Authors: Colleoni Claudio , Massafra Maria Rosaria , Migani Veronica , Rosace Giuseppe
Published: December 2010

Textile finishing includes all processes that help to maintain the value or increase the value of the textile material. It encompasses dyeing, printing, and all the finishing treatments to realize durable press, soil release, flame retardant, antistatic, antimicrobial, or water/oil repellency properties. When these properties are realized on dyed textile fabric, one effect could be ascribed to the color change induced by finishing operations. This research focuses on the assessment of color alterations occurring on the dyed cotton/polyester blended fabrics due to the nanoparticle‐sized dendrimer (DWR), dendrimer–fluorocarbon (DWOR), and fluorocarbon (FWOR) finishing onto their surfaces. The dependence of color on the surface state of treated textiles is calculated in the context of spectrophotometric measurements. Modification of the surface roughness by reflectance spectrum and the absorbance of finishes in visible range were investigated to determine color changes between the original (control fabric, dyed but not treated) and treated fabrics. As a result of color matching calculated by CIE‐Lab values, color change is related to the surface roughness associated with absorbance values of applied finishes. In addition, fabrics mechanical properties were evaluated to estimate if finishing agents application gives rise to other changes, besides color alterations. The fabrics mechanical properties have been found not significantly altered by the aforementioned finishing treatments. These results could be applied for industrial needs (quality control), or in the artistic field of conservation, or restoration (to follow the color of paintings). © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2011
Synthesis and characterization of gelatin‐polydimethylsiloxane graft copolymers
Authors: Zhang Meng , Wu Yuanjuan , Zhang Qingsi , Xia Yongmei , Li Tianduo
Published: December 2010

Gelatin‐polydimethylsiloxane (PDMS) graft copolymers were prepared through the reaction between gelatin and α‐[3‐(2,3‐epoxypropoxy)propyl]‐ω‐butyl‐PDMSs. The copolymers were characterized by FTIR and 1H‐NMR spectra. As proved by wide angle X‐ray analysis, a new characteristic crystalline peak appeared after the bonding of PDMS to gelatin chains. The microstructure and the elemental identification of gelatin and copolymers were followed through scanning electron microscope with energy dispersive spectrometer. The glass transition temperature of gelatin and copolymers were obtained by differential scanning calorimetry analysis. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2011
The Luminescence of Sr8SrGd2 □ W4O24: Eu3+; A Case with a Low‐Lying Charge‐Transfer Transition
Authors: Blasse G. , Kemmler‐Sack S.
Published: December 2010

The luminescence at low temperatures of the perovskite‐like system Sr8SrGd2‐xEux□W4O24 is reported. The charge‐transfer transition of the Eu3+ ion is situated at low energy, viz. about 29000 cm−1, which influences the luminescent properties drastically. Energy transfer from the tungstate group to Eu3+ is not efficient. This transfer process occurs mainly via the C.T. state.
ChemInform Abstract: K2[Hg(SO3)2]·2.25H2O.
Authors: Weil Matthias , Baumann Stefan O. , Breitinger Dietrich K.
Published: December 2010

Single crystals of the title compound are precipitated from an aqueous solution containing HgO and K2SO3 in the molar ratio 1:3.
ChemInform Abstract: 9Mg(OH)2·MgCl2·4H2O, a High Temperature Phase of the Magnesia Binder System.
Authors: Dinnebier Robert E. , Freyer Daniela , Bette Sebastian , Oestreich Melanie
Published: December 2010

The metastable title phase exists at the extended metastable isotherm of Mg(OH)2 in the system MgO—MgCl2—H2O at 120 °C and occurs as intermediate binder phase during setting of magnesia cement due to temperature development of the setting reaction.
ChemInform Abstract: Crystal Chemistry of the Noncentrosymmetric Eulytites: A3Bi(XO4)3 (X: V, A: Pb; X: P, A: Ca, Cd, Sr, Pb).
Authors: Sahoo Prangya Parimita , Row T. N. Guru
Published: December 2010

Polycrystalline samples of M3Bi(PO4)3 (M: Ca, Cd, Sr, Pb) are prepared by solid state reactions of stoichiometric mixtures of CaCO3, Cd(OAc)2, SrCO3, PbO, Bi2O3, and (NH4)2HPO4 (855 °C for 12 h and 950 °C for 12 h for Ca3Bi(PO4)3, 800 °C for 10 h and 980 °C for 12 h for Cd3Bi(PO4)3, 1100 °C for 12 h for Sr3Bi(PO4)3, and 875 °C for 6 h for Pb3Bi(PO4)3).
ChemInform Abstract: N‐Heterocyclic Carbene Catalyzed Asymmetric Cross‐Benzoin Reactions of Heteroaromatic Aldehydes with Trifluoromethyl Ketones.
Authors: Enders Dieter , Grossmann Andre , Fronert Jeanne , Raabe Gerhard
Published: December 2010

Moderate to good enantioselectivities are observed in the cross‐benzoin reaction of aldehydes (I) with ketones (II) in the presence of a novel triazolium salt as chiral catalyst precursor.
ChemInform Abstract: Methyl 3‐Cyclopropyl‐3‐oxopropanoate in the Synthesis of Heterocycles Having a Cyclopropyl Substituent.
Authors: Pokhodylo N. T. , Matiichuk V. S. , Obushak N. D.
Published: December 2010

Pyrrole (III), pyridine (V), benzofuran (VII), pyrazole [(IX), (XI)] and triazole derivatives (XIII) having a cyclopropyl substituent are synthesized starting from title compound (I).
ChemInform Abstract: Catalytic Ring‐Opening Allylation of Cyclic Acetals with Allylsilanes Using Silica‐Alumina.
Authors: Motokura Ken , Yoneda Hirokazu , Miyaji Akimitsu , Baba Toshihide
Published: December 2010

Consecutive ring‐opening allylation followed by hydrolysis of the formed silylethers affords homoallyloxyalcohols (III) in good to high yields.
ChemInform Abstract: Catalytic Enantioselective Alkene Epoxidation Using Novel Spirocyclic N‐Carbethoxy‐azabicyclo[3.2.1]octanones.
Authors: Armstrong Alan , Bettati Michela , White Andrew J. P.
Published: December 2010

A series of novel spirocyclic azabicyclo[3.2.1]octanones such as (I) or (II) are prepared and shown to catalyze alkene epoxidations using Oxone with up to 91.5% e.e.
ChemInform Abstract: Catalytic Mannich‐Type Reaction of Phosphorylimidates.
Authors: Kobayashi Shu , Nakano Junya , Matsubara Ryosuke
Published: December 2010

Phoshorylimidates such as (II) can function as ester equivalents in Mannich‐type reactions.
ChemInform Abstract: Synthesis and Reactions of the First Fluoroalkylated 1,3‐Bis(trimethylsilyloxy)‐1,3‐butadiens.
Authors: Buettner Stefan , Bendrath Franziska , Langer Peter
Published: December 2010

Silylation of fluoroalkylated diketones gives the title compounds which react with oxalyl chloride to give novel γ‐alkylidenebutenolides as (E)‐ or (Z)‐isomers.
ChemInform Abstract: Copper‐Catalyzed Coupling of Thiourea with Aryl Iodides: The Direct Synthesis of Aryl Thiols.
Authors: Qiao Shu , Xie Kun , Qi Junsheng
Published: December 2010

The method is general, economical, and efficient and will be potentially applied in the large‐scale industry.
ChemInform Abstract: Green Alcohol Couplings Without Transition Metal Catalysts: Base‐Mediated β‐Alkylation of Alcohols in Aerobic Conditions.
Authors: Allen Laura J. , Crabtree Robert H.
Published: December 2010

Benzylic secondary alcohols (I) are alkylated in good yields at the β‐position with primary alcohols (II) promoted by KOH or NaOH.
ChemInform Abstract: Ultrasound‐Promoted Formation of Isopentenyl Alcohol Dianion: Straightforward Synthesis of Perhydrofuro[2,3‐b]furans.
Authors: Alonso Francisco , Rodriguez‐Fernandez Mamen , Sanchez Daniel , Yus Miguel
Published: December 2010

Metalation of alcohol (I) under optimized conditions using ultrasound irradiation and subsequent reaction with carbonyl compounds gives functionalized diols.
ChemInform Abstract: Facile Synthesis of [1]Benzothieno[3,2‐b]benzothiophene from o‐Dihalostilbenes.
Authors: Saito Masahiko , Yamamoto Tatsuya , Osaka Itaru , Miyazaki Eigo , Takimiya Kazuo , Kuwabara Hirokazu , Ikeda Masaaki
Published: December 2010

Optimized reaction conditions are developed for the synthesis of title compound (II).
ChemInform Abstract: A Convenient Synthesis and Structural Analysis of Novel 4,5,6,7‐Tetrahydro‐1H‐indazoles (II)
Authors: Murugavel K. , Amirthaganesan S. , Mohan R. T. Sabapathy
Published: December 2010

7 examples
ChemInform Abstract: Recyclization of Benzimidazo[2,1‐b]thiazanium Salts into 1‐(2,3‐Epithiopropyl)benzimidazol‐2‐ones under the Action of Epichlorohydrin.
Authors: Orlov M. A. , Aslanov A. F. , Korotkikh N. I.
Published: December 2010

The proposed method enables the introduction of functional groups unstable in alkaline medium into the structure of thiirane derivatives.
ChemInform Abstract: Antibacterial Activity of 5‐Dialkylaminomethylhydantoins and Related Compounds.
Authors: Fujisaki Fumiko , Shoji Kaori , Shimodouzono Mari , Kashige Nobuhiro , Miake Fumio , Sumoto Kunihiro
Published: December 2010

Compound (III a) exhibits the highest antibacterial activity against E.
ChemInform Abstract: Rhodium‐Catalyzed Carbometalation of Ynamides with Organoboron Reagents.
Authors: Gourdet Benoit , Smith Donna L. , Lam Hon Wai
Published: December 2010

Regio‐ and stereocontrolled synthesis of multisubstituted enamides is achieved via carbometalation of ynamides with various aromatic, heteroaromatic boronic acids, triarylboroxine or arylboronic ester.
ChemInform Abstract: Synthesis of 2‐Arylbenzothiazoles Catalyzed by Biomimetic Catalyst, β‐Cyclodextrin.
Authors: Londhe Balaji S. , Pratap Umesh R. , Mali Jyotirling R. , Mane Ramrao A.
Published: December 2010

The title compounds, e.g. (III), are prepared by a simple, economic and environmentally benign procedure.
ChemInform Abstract: Microwave‐Induced Generation and Reactions of Nitrile Sulfides: An Improved Method for the Synthesis of Isothiazoles and 1,2,4‐Thiadiazoles.
Authors: Fordyce Euan A. F. , Morrison Angus J. , Sharp Robert D. , Paton R. Michael
Published: December 2010

Intermediary nitrile sulfides are generated by microwave‐assisted decarboxylation of 1,3,4‐oxathiazol‐2‐ones.
ChemInform Abstract: One‐Pot Synthesis of Polyfunctionalized 4H‐Pyran Derivatives Bearing Fluorochloro Pyridyl Moiety.
Authors: Ye Zhenjun , Xu Renbo , Shao Xusheng , Xu Xiaoyong , Li Zhong
Published: December 2010

The three‐component reaction offers a direct synthesis of the structurally important pyran system.
ChemInform Abstract: A One‐Pot Synthesis of the 1‐Benzopyrano[2,3‐b]pyridine Moiety from 2‐(Alkyl/Arylamino)‐4‐oxo‐4H‐1‐benzopyran‐3‐carbaldehyde.
Authors: Maiti Sourav , Panja Suman Kalyan , Bandyopadhyay Chandrakanta
Published: December 2010

(Benzopyrano)pyridine‐2,5‐diones, bearing various functionalities at the 3‐position, are prepared by reaction of 2‐monosubstituted aminochromonecarbaldehydes with active methylene compounds.
ChemInform Abstract: New Multicomponent Domino Reactions (MDRs) in Water: Highly Chemo‐, Regio‐ and Stereoselective Synthesis of Spiro{[1,3]dioxanopyridine}‐4,6‐diones and Pyrazolo[3,4‐b]pyridines.
Authors: Ma Ning , Jiang Bo , Zhang Ge , Tu Shu‐Jiang , Wever Walter , Li Guigen
Published: December 2010

The green protocol for the synthesis of title compounds, e.g. (IV), (VI) and (IX), has the advantage of water as reaction medium, simple conditions, easy work‐up and reduced waste production.
ChemInform Abstract: Synthesis of Some Fused Heterocycles Based on Thieno[2,3‐b]pyridine and Their Antimicrobial Activity.
Authors: El‐Essawy F. A. , Hawatta M. A. , Abdel‐Megied A. E.‐S. , El‐Sherbeny D. A.
Published: December 2010

A variety of fused heterocycles containing a pyridothienopyrimidine moiety is synthesized and evaluated for antimicrobial activity.
ChemInform Abstract: An Efficient and Environmentally Friendly Procedure for Synthesis of Pyrimidinone Derivatives by Use of a Biginelli‐Type Reaction.
Authors: Lei Min , Ma Lei , Hu Lihong
Published: December 2010

New and simple modifications of the Biginelli‐type reaction of cyclopentanone with aromatic aldehydes and urea/thiourea are described.
ChemInform Abstract: Asymmetric Reduction of Aliphatic Ketones and Acyl Silanes Using Chiral anti‐Pentane‐2,4‐diol and a Catalytic Amount of 2,4‐Dinitrobenzenesulfonic Acid.
Authors: Matsuo Jun‐ichi , Hattori Yu , Hashizume Mio , Ishibashi Hiroyuki
Published: December 2010

A wide range of linear and cyclic ketones is reduced to the corresponding alcohols with moderate yields and good to excellent enantioselectivities.
ChemInform Abstract: Solvent‐Free Microwave‐Expediated Synthesis of Ferrocenylenones and Ferrocenyl‐1,5‐diketones Using Hydrotalcite.
Authors: Raj A. R. Naresh , Hussaini Syed Sulaiman , Huq C. A. M. A. , Babu A. R. Suresh
Published: December 2010

The method is efficient, facile, extremely fast and applicable to a wide range of substrates.
ChemInform Abstract: Triterpenoid Derivatives from Cylicodiscus gabunensis.
Authors: Mkounga Pierre , Tiabou Alembert Tchinda , Kouam Jacques
Published: December 2010

The stem bark of the title tree is used in the traditional African medicine for various therapeutic purposes.
ChemInform Abstract: Lactarane Sesquiterpenoids from Lactarius subvellereus and Their Cytotoxicity
Authors: Kim Ki Hyun , Noh Hyung Jun , Choi Sang Un , Park Ki Moon , Seok Soon‐Ja , Lee Kang Ro
Published: December 2010

isolation, structure and stereochemistry of three new cytotoxic lactarane sesquiterpenoids, subvellerolactones B (I), D (IIa) and E (IIb) together with four known lactarane sesquiterpenes
ChemInform Abstract: Oppositinines A and B: New Vasorelaxant β‐Carboline Alkaloids from Neisosperma oppositifolia.
Authors: Awang Khalijah , et al. et al.
Published: December 2010

The two isolated oppositinines A (I) and B (II) exhibit potent vasorelaxant effects on the rat aorta.
ChemInform Abstract: Novel Alkaloids from Alstonia scholaris.
Authors: Cai Xiang‐Hai , Shang Jian‐Hua , Feng Tao , Luo Xiao‐Dong
Published: December 2010

Novel alkaloids, scholarisine I (I) and scholarisine II (II), are isolated, and a possible biogenesis is proposed.
ChemInform Abstract: Fimbrolide Disulfanes: Synthesis and Crystal Interactions
Authors: Kutty Samuel K. , Bhadbhade Mohan M. , Iskander George , Bishop Roger , Griffith Renate , Black David StC. , Kumar Naresh
Published: December 2010

The crystal structure analysis of disulfanes (V) reveals intermolecular halogen bonding and carbonyl—carbonyl dipolar interactions.
ChemInform Abstract: Azaphilone and Isocoumarin Derivatives from the Endophytic Fungus Penicillium sclerotiorum PSU‐A13.
Authors: Arunpanichlert Jiraporn , Rukachaisirikul Vatcharin , Sukpondma Yaowapa , Phongpaichit Souwalak , Tewtrakul Supinya , Rungjindamai Nuttawut , Sakayaroj Jariya
Published: December 2010

From the culture broth of the title fungus penicilazaphilone A (Ia), B (Ib) and penicilisorin (II) are isolated.
ChemInform Abstract: Artoindonesianin F, a Potent Tyrosinase Inhibitor from the Roots of Artocarpus heterophyllys Lam.
Authors: Rao G. Venkateswara , Mukhopadhyay T. , Radhakrishnan N.
Published: December 2010

Tyrosinase inhibition activity‐guided fractionation of the EtOAc extract of breadfruit tree roots yields the stilbene derivative artoindonesianin F (I).
ChemInform Abstract: Synthesis of a Series of Novel 2,4,5‐Trisubstituted Selenazole Compounds as Potential PLTP Inhibitors.
Authors: Ling Cui , Zheng Zhibing , Jiang Xian Cheng , Zhong Wu , Li Song
Published: December 2010

The title compounds are evaluated for their plasma phospholipid transfer protein (PLTP) inhibiting activities.
ChemInform Abstract: Solid‐State Electrochemical Reactions of Electroactive Microparticles and Nanoparticles in a Liquid Electrolyte Environment
Authors: Hermes Michael , Scholz Fritz
Published: December 2010

Review: 151 refs.
ChemInform Abstract: Disorder in Low Dimensions: Localization Effects in Spin Glass Wires and Cold Atoms
Authors: Carpentier D. , Orignac E. , Paulin G. , Roscilde T.
Published: December 2010

Review: 66 refs.
ChemInform Abstract: Metal—Organic Frameworks (MOFs) and Coordination Polymers
Authors: Noro Shin‐ichiro , Kitagawa Susumu
Published: December 2010

Review: 183 refs.
ChemInform Abstract: Mechanism of the Oxidative Addition of Aryl Halides to Bis‐Carbene Palladium(0) Complexes
Authors: Jutand Anny , Pytkowicz Julien , Roland Sylvain , Mangeney Pierre
Published: December 2010

Review: 35 refs.
ChemInform Abstract: Recent Progress in the Application of N‐Halo Reagents in the Synthesis of Heterocyclic Compounds
Authors: Veisi Hojat , Ghorbani‐Vaghei Ramin
Published: December 2010

Review: 153 refs.
ChemInform Abstract: 2‐Azapurine Nucleosides: Synthesis, Properties, and Base Pairing of Oligonucleotides
Authors: Budow Simone , Seela Frank
Published: December 2010

Review: 82 refs.
ChemInform Abstract: Structures, Mechanisms, and Results in Bifunctional Catalysis and Related Species Involving Proton Transfer
Authors: Grotjahn Douglas B.
Published: December 2010

Review: 66 refs.
ChemInform Abstract: Chemistry of Vinylidenecyclopropanes
Authors: Shi Min , Shao Li‐Xiong , Lu Jian‐Mei , Wei Yin , Mizuno Kazuhiko , Maeda Hajime
Published: December 2010

Review: 258 refs.
ChemInform Abstract: The Asymmetric [C + NC + CC] Coupling Reaction: Development and Application to Natural Product Synthesis
Authors: Garner P. , Kaniskan H. U.
Published: December 2010

Review: 96 refs.
ChemInform Abstract: Highlights in the Solid‐Phase Organic Synthesis of Natural Products and Analogues
Authors: Eifler‐Lima Vera Lucia , Graebin Cedric S. , De Toni Uchoa Flavia , Duarte Patricia D. , Correa Arlene G.
Published: December 2010

Review: 96 refs.
ChemInform Abstract: Isocyanoacetate Derivatives: Synthesis, Reactivity, and Application
Authors: Gulevich Anton V. , Zhdanko Alexander G. , Orru Romano V. A. , Nenajdenko Valentine G.
Published: December 2010

Review: 634 refs.
ChemInform Abstract: FtsK DNA Translocase: The Fast Motor that Knows Where It′s Going
Authors: Crozat Estelle , Grainge Ian
Published: December 2010

Review: 62 refs.
ChemInform Abstract: Time—Temperature Indicators for Perishable Products
Authors: Maschietti Marco
Published: December 2010

Review: 57 refs.
Mining Web search engines for query suggestion
Authors: Xu Zheng , Luo Xiangfeng , Yu Jie , Xu Weimin
Published: December 2010

Queries to Web search engines are usually short and ambiguous, which provides insufficient information needs of users for effectively retrieving relevant Web pages. To address this problem, query suggestion is implemented by most search engines. However, existing methods do not leverage the contradiction between accuracy and computation complexity appropriately (e.g. Google's ‘Search related to’ and Yahoo's ‘Also Try’). In this paper, the recommended words are extracted from the search results of the query, which guarantees the real time of query suggestion properly. A scheme for ranking words based on semantic similarity presents a list of words as the query suggestion results, which ensures the accuracy of query suggestion. Moreover, the experimental results show that the proposed method significantly improves the quality of query suggestion over some popular Web search engines (e.g. Google and Yahoo). Finally, an offline experiment that compares the accuracy of snippets in capturing the number of words in a document is performed, which increases the confidence of the method proposed by the paper. Copyright © 2010 John Wiley & Sons, Ltd.
Iron(III)‐Pivalate‐Based Complexes with Tetranuclear {Fe4(μ3‐O)2}8+ Cores and N‐Donor Ligands: Formation of Cluster and Polymeric Architectures
Authors: Baca Svetlana G. , Filippova Irina G. , Keene Tony D. , Botezat Olga , Malaestean Iurii L. , Stoeckli‐Evans Helen , Kravtsov Victor Ch. , Chumacov Iurii , Liu Shi‐Xia , Decurtins Silvio
Published: December 2010

Different synthetic routes have been used for the preparation of a new tetranuclear [Fe4O2(O2CCMe3)8(bpm)] cluster (1) and a one‐dimensional coordination polymer [Fe4O2(O2CCMe3)8(hmta)]n (2) (bpm = 2,2′‐bipyrimidine and hmta = hexamethylenetetramine). For cluster 1, two structural isomers, 1a and 1b·3MeCN, have been found. X‐ray crystallographic analysis showed that all complexes consist of a central {Fe4(μ3‐O)2}8+ core. In 1a, metal ions in the core are additionally linked by six bridging pivalates as two other pivalates and a bpm ligand are chelated to FeIII ions, whereas in cluster 1b, metal ions in the {Fe4(μ3‐O)2}8+ core are linked by seven bridging pivalates and only one carboxylate as well as bpm are chelated to the iron centers. In coordination polymer 2, [Fe4O2(O2CCMe3)8] clusters are bridged by hmta ligands to form zigzag chains. Magnetic measurements have been carried out to characterize these complexes and revealed antiferromagnetic interactions between FeIII ions with best‐fit parameters of Jwb = –72.2 (1a) and –88.7 cm–1 (1b) for wing···body interactions.
Synthesis and Structural Characterization of New Bimetallic [C,N,S] Palladacycles with Mixed Bridging [P,P] and Chelating [P,P] or [P,N] Phosphane Ligands
Authors: Antelo José M. , Adrio Luis , Pereira M. Teresa , Ortigueira Juan M. , Fernández Alberto , Vila José M.
Published: December 2010

Treatment of bimetallic palladacycles with silver perchlorate, followed by reaction with tertiary diphosphanes or diphenyl‐2‐pyridylphosphane gave novel dipalladium compounds with chelating [C,N,S], bridging [P,P], and chelating [P,P] or [P,N] ligands, as appropriate. The short‐chain diphenyl‐2‐pyridylphosphane ligand forms stable four‐membered P–N chelates, which display S–Pd–P and N–Pd–P trans geometries. The Pd–Cl bonds are nonreactive towards displacement by the [P,P] or [P,N] ligands, even in the case of strong chelating diphosphanes.
[{2,6‐(Me2NCH2)2C6H3}Sn(μ‐OH)W(CO)5]2: A Transition‐Metal‐Coordinated Organotin(II) Hydroxide
Authors: Jambor Roman , Herres‐Pawlis Sonja , Schürmann Markus , Jurkschat Klaus
Published: December 2010

The synthesis of the intramolecularly coordinated pentacarbonyltungsten–organostannylene complexes {2,6‐(Me2NCH2)2C6H3}Sn(H)W(CO)5 (2) and [{2,6‐(Me2NCH2)2C6H3}Sn(μ‐OH)W(CO)5]2 (3) and the solid‐state molecular structure of 3, as determined by single‐crystal X‐ray diffraction analysis, are reported. Compound 3 is characterized by hydroxido bridges [Sn–O 2.068(5), 2.231(5) Å], an intramolecular N→Sn coordination bond [2.501(7) Å] and an intramolecular O–H···N hydrogen bond [O···N 2.715(8) Å].
Comprehensive DFT Study on Site‐, Regio‐, and Stereoselectivity of Diels–Alder Reactions Leading to 5‐Hydroxybenzofurans
Authors: Brasca Romina , Kneeteman María N. , Mancini Pedro M. E. , Fabian Walter M. F.
Published: December 2010

Diels–Alder reactions between the substituted furans 1a–1c and Danishefsky's diene (2), yielding 5‐hydroxybenzofurans, were studied by density functional theory [B3LYP/6‐31G(d) level] in benzene as solvent (SP/CPCM). The mechanistic details of these reactions, especially with respect to regio‐, site‐, and stereochemistry were analyzed in detail. Moreover, the extrusion of nitrous acid from the Diels–Alder cycloadducts and the formation of the aromatic products were also explained in order to give a total description of the complete domino processes.
Bifunctional 2,5‐Diketopiperazines as Rigid Three‐Dimensional Scaffolds in Receptors and Peptidomimetics
Authors: Ressurreição Ana Sofia M. , Delatouche Régis , Gennari Cesare , Piarulli Umberto
Published: December 2010

2,5‐Diketopiperazines (DKPs) are heterocyclic scaffolds easily accessible from α‐amino acids and characterized by rather flat six‐membered‐ring cores that can be functionalized at four positions (N1, N4, C3, C6), two of which are stereogenic centers (C3, C6). In this microreview, the syntheses and the solution conformations of several DKP scaffolds are discussed with regard to their application as two‐armed receptors for the selective recognition of small peptides and anions and as peptidomimetics mimicking topologically relevant elements of protein secondary structure (e.g., β‐turns, β‐hairpins, and α‐helices). In many cases the properties of these compounds can be interpreted in terms of their conformationally defined three‐dimensional structures, which can be assessed by spectroscopic and computational methods.
Room‐Temperature Columnar Liquid‐Crystalline Perylene Imido‐Diesters by a Homogeneous One‐Pot Imidification–Esterification of Perylene‐3,4,9,10‐tetracarboxylic Dianhydride
Authors: Kelber Julien , Bock Harald , Thiebaut Olivier , Grelet Eric , Langhals Heinz
Published: December 2010

The reaction of PTCDA (perylene‐3,4,9,10‐tetracarboxylic dianhydride) with an alcohol, a bromoalkane, and an alkylamine in the presence of DBU in DMF yields imido‐diester‐substituted perylenes. The reaction is limited to polar alcohols such as propanol, but longer alkyl chains are efficiently introduced in a second step by alkyl group exchange by using selective acidic ester hydrolysis that leaves the imide group intact. This amine‐efficient approach to imido‐diesters is used to obtain acceptor‐type self‐assembling dyes that form a hexagonal columnar liquid crystalline phase at room temperature.
Traffic models for future backbone networks – a service‐oriented approach
Authors: Palkopoulou E. , Merkle C. , Schupke D. A. , Gruber C. G. , Kirstädter A.
Published: December 2010

In this paper we present a novel approach to assess the impact of new and existing services on traffic volume in current and future backbone networks. Several proposals to model traffic load in access and backbone networks exist in the literature. These proposals consider current Internet traffic like http, smtp, ftp and Peer‐to‐Peer (P2P). We expect, however, that there will be a change in traffic load for future networks caused by services like IP Television (IPTV), Video on Demand (VoD) and Virtual Private Networks (VPN). Additionally, population‐based models may no longer be applicable due to the widespread use of service‐providers and hierarchical routing through network peering points. Therefore, it is important to reassess future traffic volumes and traffic patterns and to identify those services that have the most impact on the networks. We model today's traffic volume of each of the described services and estimate future traffic volumes taking peering points into account. To illustrate the different traffic flows and to characterise the traffic distribution we apply our results to a Germany reference network. Copyright © 2010 John Wiley & Sons, Ltd.
Long‐term effectiveness of collaborative depression care in older primary care patients with and without PTSD symptoms
Authors: Chan Domin , Fan Ming‐Yu , Unützer Jürgen
Published: December 2010

Objective

Depressed patients with comorbid post‐traumatic stress disorder (PTSD) are more functionally impaired and may take longer to respond to depression treatment than patients without PTSD. This study examined the long‐term effects of PTSD on depression severity, treatment response, and health care costs among older adults.

Methods

Patients were recruited from 18 primary care clinics in five states. A total of 1801 patients aged 60 years or older with major depression or dysthymia were randomized to Improving Mood Promoting Access to Collaborative Treatment (IMPACT) collaborative care or usual care. The study included 191 (10.6%) subjects who screened positive for PTSD. Depression severity, assessed by the Hopkins Depression Symptom Checklist, was used to estimate depression‐free days (DFDs) over 24 months. Total health care costs included inpatient, outpatient, and pharmacy costs.

Results

Depressed patients with PTSD had higher depression severity than patients without PTSD symptoms at baseline. Over 2 years, intervention patients with PTSD symptoms had relatively the same benefits from collaborative care (99 more DFDs than usual care patients) as patients without PTSD (108 more DFDs than usual care) (p = 0.85). Total health care costs did not differ significantly for depressed patients with and without PTSD symptoms.

Conclusion

Depressed older adults with PTSD symptoms were more depressed at baseline, but collaborative care (compared to usual care) produced similar improvements in depression severity in both groups. This reduction of depression symptoms was observed for up to 12 months after the intervention ended, suggesting that long‐term improvements in depression are possible with collaborative care in patients with and without PTSD symptoms. Copyright © 2010 John Wiley & Sons, Ltd.
Impact of average weekly dose of radiation during radiotherapy alone or chemoradiotherapy in head and neck cancer
Authors: Dragovic Aleksandar F. , Bonner James A. , Spencer Sharon A. , Nabell Lisle M. , Carroll William R. , Caudell Jimmy J.
Published: December 2010

Background

Altered fractionated radiotherapy (RT) has been shown to improve locoregional control (LRC) and overall survival (OS) in squamous cell cancer of the head and neck (SCCHN). We investigated patient outcomes using a new parameter: the average weekly dose (AWD).

Methods

The medical records of 601 patients who received definitive RT for SCCHN were reviewed. AWD was calculated by dividing the total dose in Gray (Gy) by overall treatment time in weeks, and assessed for predictive value.

Results

Various standard RT fractionation schedules were used. An AWD >10.0 Gy was associated with improved LRC at 2 years for patients treated with RT alone (80.9% vs 60.9%;p= .006), but not for those treated with concurrent chemoradiation (75.3% vs 77.3%;p= .77). Nonsignificant increases in late dysphagia were seen with AWD >10.0 Gy.

Conclusion

An AWD of >10 Gy was found to be beneficial for RT alone regimens but not chemoradiotherapy regimens. Head Neck, 2011
Self‐healing biomaterials
Authors: Brochu Alice B. W. , Craig Stephen L. , Reichert William M.
Published: December 2010

The goal of this review is to introduce the biomaterials community to the emerging field of self‐healing materials, and also to suggest how one could utilize and modify self‐healing approaches to develop new classes of biomaterials. A brief discussion of thein vivomechanical loading and resultant failures experienced by biomedical implants is followed by presentation of the self‐healing methods for combating mechanical failure. If conventional composite materials that retard failure may be considered zeroth generation self‐healing materials, then taxonomically speaking, first generation self‐healing materials describe approaches that “halt” and “fill” damage, whereas second generation self‐healing materials strive to “fully restore” the prefailed material structure. In spite of limited commercial use to date, primarily because the technical details have not been suitably optimized, it is likely from a practical standpoint that first generation approaches will be the first to be employed commercially, whereas second generation approaches may take longer to implement. For self‐healing biomaterials the optimization of technical considerations is further compounded by the additional constraints of toxicity and biocompatibility, necessitating inclusion of separate discussions of design criteria for self‐healing biomaterials. © 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part A:, 2011.
HDAC inhibitor vorinostat enhances the antitumor effect of gefitinib in squamous cell carcinoma of head and neck by modulating ErbB receptor expression and reverting EMT
Authors: Bruzzese Francesca , Leone Alessandra , Rocco Monia , Carbone Carmine , Piro Geny , Caraglia Michele , Di Gennaro Elena , Budillon Alfredo
Published: December 2010

Potentiation of epidermal growth factor receptor (EGFR) inhibitors is required in squamous cell carcinoma of head and neck (SCCHN) to improve their therapeutic index. We demonstrated that the histone deacetylase inhibitor vorinostat in combination with the EGFR tyrosine kinase inhibitor gefitinib induced synergistic inhibition of proliferation, migration, and invasion as well as induction of apoptosis in SCCHN cells, including cells resistant to gefitinib. We provided evidence suggesting that differential modulation of ErbB receptors together with reversion of epithelial‐to‐mesenchymal transition (EMT) by vorinostat represent mechanistic bases for the observed synergism. We demonstrated in epithelial CAL27 cells expressing EGFR, ErbB2, and ErbB3 that vorinostat downregulated the expression and signaling of all three receptors. In gefitinib‐resistant KB and Hep‐2 cells, both of which had undergone EMT and expressed very low levels of ErbB3, vorinostat reverted the mesenchymal phenotype by inducing both E‐cadherin and ErbB3 and downregulating vimentin as well as EGFR and ErbB2. Both transcriptional and post‐translational mechanisms were involved in the modulation of ErbB receptors by vorinostat. Attenuation of all ErbB transcripts in CAL27 cells as well as induction of ErbB3 transcript in Hep‐2 and KB cells was seen upon vorinostat treatment. We showed that vorinostat induced ubiquitination of EGFR and ErbB2 and targeted them predominantly to lysosome‐degradation in all cell lines, while the induction of ErbB3‐ubiquitination in CAL27 cells led to proteasomes‐degradation. Overall, this study suggests that the vorinostat/gefitinib combination represents a promising therapeutic strategy that warrants further clinical evaluation in SCCHN, including tumors intrinsically resistant to EGFR‐inhibitors. J. Cell. Physiol. 226: 2378–2390, 2011. © 2010 Wiley‐Liss, Inc.