bluuebunny/crossref_metadata_2025 huggingface dataset:
Belarusian model of higher education services export: Its background and current challenges
Authors:   Tomsk State University, Pogorelskaya Anastasia M.
Published: October 2024

The research aims to identify the features of the Belarusian model of higher education services export. The research objectives are to characterize the place of the Republic of Belarus at the global market of higher education services, identify the prerequisites for the formation of its model for the higher education services export, and identify the key factors influencing the current functioning of this model. The peculiarity of the Belarusian model of higher education services export is attracting international students directly in the country, instead of developing foreign branch campuses or dual-diploma programs. The formation of this model was influenced by the dominance of public sector in higher education and the overall limited potential of the higher education system. However, since 2007 the Republic of Belarus has been pursuing the policy of stimulating educational export. This policy was successful in increasing the turnover and balance of foreign trade in educational services, as well as reducing the traditionally negative balance of international student mobility for the country. The factor influencing positively the Belarusian export of higher education services is its competitive advantage, namely, its relatively low cost of higher education for international students. However, the international situation since 2022 prevents the Belarusian higher education system from being a transit point for international students receiving Belarusian higher education for further relocation to the European Higher Education Area countries. From a theoretical point of view, this research is intended to initiate a discussion about the place and policy features of small countries in the higher education services market. Taking into account the historical kinship of the Russian and Belarusian higher education systems, as well as the similarity of the international situation that has developed for them, understanding the experience of the Republic of Belarus allows formulating the following recommendations for the development of Russian export of higher education services: it is necessary to maintain the level of financing for higher education comparable to the competitors and a high quality of higher education; it is worth updating and expanding the contractual basis for educational cooperation, in particular, seeking to expand the number of agreements on the mutual recognition of educational documents; it is worth supporting a variety of formats for exporting higher education services, including the incoming student mobility, creation of foreign branch campuses of Russian universities and network/dual-diploma programs.
Factors influencing central bank base rates in the context of economic policy uncertainty
Authors:   Novosibirsk State University, Bekareva Svetlana V. , Isupova Ekaterina N. ,   Sanya University, Fedoseeva Anna S. ,   Novosibirsk State University
Published: October 2024

The relevance of the research topic is determined by the current unstable state of the world economy and the increasing role of central banks, which have the ability to positively influence countries’ economic development. Central banks, when implementing monetary policy, adhere to a certain strategy and accepted methods, including using monetary policy rules. The aim of this study is to evaluate the Taylor rule linking the central bank’s benchmark interest rate, the inflation rate, and the deviation of a country’s economic development from its trajectory. Developing the Taylor rule, we add a factor to the central bank reaction equation that reflects the level of uncertainty. The econometric assessment is based on statistics for two countries, the USA and the Russian Federation, whose central banks currently adhere to different monetary policy regimes introduced at different times. Despite differences between the countries’ economies and central banks’ monetary policies, uncertainty-related indices have shown their significance.
International trade of aquatic biological resources with the countries of Northeast Asia as a factor of the economic growth of the Far Eastern Federal District territories
Authors:   Admiral Nevelskoy Maritime State University, Saltykov Maksim A. ,   Vladivostok Branch of the Russian Customs Academy, Komogortseva Zlata Yu. ,   Vladivostok Branch of the Russian Customs Academy, Kalyagin Matvei M. ,   Vladivostok Branch of the Russian Customs Academy
Published: October 2024

The aim of the article is to discuss the formed system of aquatic biological resources trade relations with the countries of Northeast Asia in the implementation of the regional development strategy of the Far Eastern Federal District. The article substantiates the relevance of using a new model of international trade of aquatic biological resources, which would take into account the development needs of the region and industry. It is shown that the changing conditions of the international market for aquatic biological resources, foreign economic sanctions, the established profile of trade relations as a supplier of raw materials, the discrepancy between the export strategy and the needs of the domestic market to provide the population with fish products require the use of innovations in the management of foreign trade of aquatic biological resources. The object of the study is international trade relations concerning aquatic biological resources between the territories of the Far Eastern Federal District and the countries of Northeast Asia. The focus of the study is the regional and foreign economic policy of the territories of the Far Eastern Federal District. The study presents the main directions of scientific work in the field of conceptual justification of the current stage of economic relations with the countries of the Asia–Pacific region. Strategic documents defining trade and economic relations between the territories of the Far Eastern Federal District and the countries of Northeast Asia were analyzed, and a conclusion was made about the relevance of developing a regional concept for the production and export of aquatic biological resources. The commodity and country structure of food exports from the Far Eastern Federal District is analyzed. The characteristics of the modern model of interregional trade of the aquatic biological resources of the territories of the Far Eastern Federal District with the countries of Northeast Asia are presented. In conclusion, the question is raised about the necessary organizational and economic innovations that ensure an increase in the economic effect for the economies of the regions supplying products to foreign markets, and the tasks that need to be solved to improve the efficiency of trade relations with Asia–Pacific countries are identified.
Management and infrastructure for the implementation of promising international marine projects in the Arctic Zone of the Russian Federation
Authors:   Saint Petersburg State University of Civil Aviation, Chernyak Tatyana A.
Published: October 2024

The article considers global and regional levels of management of infrastructure support for the development of Arctic territories. It reveals the most pressing issues of joint exploitation of the Arctic territories in the interests of the Arctic Council countries. The Arctic Council, as a representative body at the international level of economic relations, acts as a management entity declaring the boundaries and priorities of the use of resources, opportunities and immediate territories of the Arctic zones. The presented article reflects the main priorities of the development of the Arctic regions at the international level. The priorities of management and individual management functions in the development of business relations in the Arctic Zone are determined. The article systematizes a number of scientific and practical tasks, the solution of which is necessary for the development of transport channels, but somehow affects the conservation of marine ecosystems of the Arctic seas. Priorities have been set in the use of marine resources, based on the systematization of international proposals for the joint use of Arctic territories. The method of induction is used to classify the subjects of management in the study. Management entities at the international level have been grouped. The international priorities of cooperation research at the macroeconomic level have been determined. The key results of international cooperation of states in the Arctic are presented. Possible sectors of combining domestic and foreign interests in the development of Arctic territories are identified. The difficulties in the implementation of management of the Arctic regions on the territory of the Russian Federation are substantiated. The key differences between the Southern Sea and Northern Sea transport infrastructures serving the development of East–West relations are identified. Priorities in the use of the Northern Sea Route are identified. The prospects of integration of Russian economic activities into promising directions of international transport communication development in the Arctic territories are revealed.
Professional choice of a student: Guidelines, expectations and factors in making the decision to enter a university
Authors:   Kazan National Research Technical University named after A.N. Tupolev, Chugunov Kirill V. , Nikolaeva Anna B. ,   Kazan National Research Technical University named after A.N. Tupolev, Yudina Svetlana V. ,   Kazan National Research Technical University named after A.N. Tupolev
Published: October 2024

The article analyzes students’ expectations and professional guidelines, and factors influencing the choice of a specific university for higher education. In the process of searching for a new identity, Russian universities need reliable information about the demands of stakeholders. The article proves that sociological surveys among students, contrary to the growing opinion among experts, can serve as a source of such data. In addition, the results of the study refute the point of view about growing professional skepticism among students, although in this case the dependence on the future specialty is clearly recorded. In the authors’ opinion, great efforts, when making decisions (including government ones), must be directed to the harmonization of all “three missions” of the university, and especially to student science. The article summarizes the results of an empirical sociological study. The research samples were quota, stratified by areas of training, the second sample was stratified by course of study. The volume of the first sample was 580 people aged 18 to 20; the size of the second sample was 964 people aged 19 to 25. As a result of the study, the authors found the following: professional optimism of student youth is sufficiently associated with obtaining higher education; students are not characterized by infantilism and weak professional orientation; students’ awareness and optimism in the field of Russian science is low; students often make decisions about their professional choice independently, but often under the influence of “random” factors; freshmen are more optimistic about their professional future compared to seniors. The study demonstrated the need for regular monitoring of the professional expectations and orientations of students at universities in order to better understand, among other things, their development prospects and their strategic goals.
Investment tax deduction (credit): Economic substance, accounting and identification of deferred taxes
Authors:   Kuban State University, Aksent’ev Andrei A. ,   Perspektiva LLC
Published: October 2024

The article considers the features of investment tax deduction (credit) from the economic and accounting points of view. The research is based on the analysis of the US practice from 1962. The methodological approaches to accounting of investment tax credit developed by the Accounting Principles Board in 1962–1964 are analysed. Two forms of influence of investment tax credit on the financial position of the organisation are distinguished: (1) the tax credit is a supplement to the mechanism of depreciation deductions; (2) its application reduces the tax base of the asset by the amount of the investment tax credit or to zero. It is determined that investment tax credit is a special form of financial subsidy, the economic benefits of which lie in the part of the tax flow, as the state waives the taxes due to it for the sake of stimulating investments. Three approaches of investment tax credit accounting are characterised: (1) contribution to capital; (2) cost reduction; (3) tax reduction. The author’s approach to the recognition of investment tax credits is proposed for two situations: (1) the application of the tax benefit does not affect the tax base of the asset; (2) the tax base of the asset is reduced to zero or by the amount of the investment tax credit. It is determined that the investment tax credit is not a deferred tax; however, the realisation of the investment tax credit may affect the tax base of the asset, resulting in the need for interperiod allocation of tax effects at the initial recognition of the asset. It is concluded that a deferred credit account should be used to record a “liability” to the government until the full benefit of the investment tax credit has been realised by the entity; therefore, the deferred credit account should be amortised as the rights to the tax benefit become fixed. It is also emphasised that the specific nature of the investment tax credit does not allow the deferred credit account to be related to the deferred income account, as the deferred income account follows the principle of matching income and expenses, while the deferred credit account is used to reconcile the tax cash flow with the financial cash flow; therefore, the deferred credit is treated primarily as an accounting liability and not as deferred income.
Development of the fast payment system technology
Authors:   Financial University under the Government of the Russian Federation, Dorofeev Mikhail L. , Grishin Anton V. ,   Financial University under the Government of the Russian Federation; International Institute of Informatization and Public Administration named after P.A. Stolypin, Demkina Anastasia V. , Kosyrev Stepan M. ,   International Institute of Informatization and Public Administration named after P.A. Stolypin, Dorofeeva Nadezhda P. ,   School No. 1273 Moscow
Published: October 2024

The article overviews the potential directions for the development and improvement of cross-border transfer service of the fast payment system provided by the Bank of Russia. This study is relevant due to the need of analyzing tendencies and perspectives of the development of the dynamic and expanding market of cross-border financial operations from the Russian Federation to other countries since the realization of cross-border transactions has become significantly more complicated because of serious sanctions introduced in 2022. This article aims at studying further directions of the Russian fintech solutions in the field of cross-border transactions in current circumstances. This study completes the following tasks. First, it carries out an integral evaluation of opportunities and explains the practical significance of the transfer service of the fast payment system provided by the Bank of Russia, which was launched in 2022. Second, it formulates proposals and recommendations for the development of the future payment services that could be used for cross-border financial operations in the context of international sanctions. The article analyzes the international experience in the field of payment services integration, highlights key tendencies of cross-border transactions market where money is transferred from Russia to the neighboring countries. As a result, it proposes to consider an elaboration of a hybrid and flexible mechanism to integrate the Russian fast payment system with the fast payment services of other Eurasian countries. Organizing such a pilot project will allow specialists to have a comprehensive picture of the perspectives and limitations of such a mechanism in the region. The study includes a SWOT-analysis of the development perspectives of the fast payment system cross-border transfer service, presents concept models for carrying out payments through the fast payment system cross-border transfer service and integrating the Russian and foreign fast payment services, and analyzes the accessible statistics and law initiatives in the market of cross-border transfers in Eurasia. The article also describes already implemented services within the fast payment system: money transfers to and from Russia from person to person, payments to foreign merchants via QR codes. It outlines the possibilities that the development of the cross-border service via the fast payment system opens up in the context of financial sanctions. The article explores prospects and describes the risks of implementing the B2B cross-border transfer scenario through the fast payment system.
Methods for distribution of overhead costs in enterprises with complex organizational structures
Authors:   National Research Tomsk Polytechnic University, Yudakhina Olga B. , Zhdanova Anna B. ,   National Research Tomsk Polytechnic University
Published: October 2024

Classifications of calculation methods in enterprises with a complex organizational structure are considered. The feasibility of using the method of distributing counter services using a system of linear algebraic equations is substantiated. An algorithm for calculating cost using the balance method is presented. In accordance with the algorithm, the total costs of all divisions of the conditional enterprise were calculated, taking into account the counter services provided, and, based on the results obtained, the procedure for reflecting these costs in the accounting accounts was presented.
Immunohistochemistry (IHC) on mouse brain slices v1
Authors: Michael Coughlin Gerard
Published: October 2024

This protocol provides a starting point for immunohistochemical localization and visualization of proteins in mouse brain tissue. This can be useful for marking cell types of interest or investigating the effect of experimental manipulations on protein expression and/or localization. This protocol is compatible with free-floating tissue or tissue that has already been mounted onto a slide.
DETERMINATION OF SUPERIOR BEAN GENOTYPES IN COOKING AND PHYSICAL BY MULTI-CRITERIA DECISION-MAKING METHOD
Authors: Karaman Ruziye , Türkay Cengiz , Odabaş Mehmet Serhat
Published: October 2024

It is aimed to examine and predict the effects of bean genotypes using cooking and physicochemical properties on seed quality index and yield in this study. The seed quality index was calculated by combining the analytical hierarchical process and standard scoring functions, which is one of the multi-criteria decision-making methods, using the linear combination technique. To determine the seed quality index, a data set was created with 11 indicators. analytical hierarchical process was used to weight importance levels of examined traits depending on the genotypes. Seed quality index of registered cultivars according to investigated characteristics of cultivars and genotypes IV. Class, 6 genotype (Bombay genotype) was found to be in class V. Obtained seed quality and physical properties by determining with seed quality index obtained in this study, estimation of seed quality in beans with analytical hierarchical process was evaluated successfully. As a result, according to seed quality index of bean cultivars and genotypes, it was determined that genotype 6 had superior characteristics in terms of productivity, in addition genotypes 8 with 9 and registered cultivars could also show superior characteristics.

Keywords: Analytical hierarchical process, Cooking characteristics, Legumes, Physical properties, Yield
EFFECT OF SOIL CONDITIONERS APPLIED TO SEED ON GRAIN YIELD AND YIELD CHARACTERISTICS IN WHEAT
Authors: Yüksel Orhan , Balkan Alpay , Balaban Göçmen Damla , Bilgin Oğuz , Başer İsmet
Published: October 2024

This study, researching the effect of seed treatment with liquid soil conditioners on yield properties of bread
wheat varieties, was carried out during 2017 and 2018 years in the experimental field of Tekirdag Namik Kemal
University Faculty of Agriculture, Department of Field Crops. The experiments were conducted with 3 bread
wheat varieties and 4 soil amendments (control + 3 different liquid soil amendments) in 3 repetitions. In the
experiment, 4 different treatments including 3 different soil regulators and 1 control (T1: Control; T2: 13-5-
8+glycine betaine; T3: 15% organic matter, 15% humic and fulvic acid+0.03% potassium and T4: 25% organic
matter + 65% humic acid + 6% potassium (T4) were made. Seeds treated with a spray and then dried were sown
as split plot experimental design. In the study, the variations in the plant height (PH), spike length (SL), number
of spikelets per spike (NSS), number of grains per spike (NGS), grain weight per spike (GWS), spike fertility
index (SFI), harvest index (HI) and grain yield (GY) parameters were investigated for the bread wheat varieties.
According to the research results, all soil conditioners applied to seeds were determined to affect the investigated
characters at a statistically significant level. For the PH parameter, T3 treatment caused a significant increase,
while for the SFI parameter, T2 treatment caused a significant increase. For the HI parameter, treatments T2
and T3 had the highest effect. Spike characteristics like SL, NSS and NGS increased compared to controls with
all soil conditioner treatments, while parameters like GWS and SFI differed according to variety. Grain yield,
the most important parameter for wheat, provided the highest results in different soil conditioner treatments
depending on the varieties. T4 treatment caused clear increases in the SL, NSS, NGS, GWS and GY parameters.
According to the data obtained was evaluated, soil conditioner applications caused a significant increase in the
parameters examined in wheat. T4, which contains 25% organic matter + 65% humic acid + 6% potassium, was
determined as the most effective soil conditioner for many parameters.
TRANSFORMER NETWORKS TO CLASSIFY WEEDS AND CROPS IN HIGH-RESOLUTION AERIAL IMAGES FROM NORTH-EAST SERBIA
Authors: Celik Fatih , Balık Şanlı Füsun , Boziç Dragana
Published: October 2024

The intricate backgrounds present in crop and field images, coupled with the minimal contrast between weedinfested areas and the background, can lead to considerable ambiguity. This, in turn, poses a significant
challenge to the resilience and precision of crop identification models. Identifying and mapping weeds are pivotal
stages in weed control, essential for maintaining crop health. A multitude of research efforts underscore the
significance of leveraging remote sensing technologies and sophisticated machine learning algorithms to enhance
weed management strategies. Deep learning techniques have demonstrated impressive effectiveness in a range
of agricultural remote sensing applications, including plant classification and disease detection. High-resolution
imagery was collected using a UAV equipped with a high-resolution camera, which was strategically deployed
over weed, sunflower, tobacco and maize fields to collect data. The VIT models achieved commendable levels of
accuracy, with test accuracies of 92.97% and 90.98% in their respective evaluations. According to the
experimental results, transformers not only excel in crop classification accuracy, but also achieve higher
accuracy with a smaller sample size. Swin-B16 achieved an accuracy of 91.65% on both the training and test
datasets. Compared to the other two ViT models, the loss value is significantly lower by half, at 0.6450.
FORAGE YIELD AND QUALITY OF INTERCROPPED ANNUAL RYEGRASS WITH BERSEEM CLOVER SOWN AT DIFFERENT SEED MIXTURE RATIOS UNDER RAINFALL CONDITIONS OF MEDITERRANEAN CLIMATE
Authors: Dönmez Hasan Beytullah , Gökten Adnan , Hatipoğlu Rüştü
Published: October 2024

This research was carried out under rainfall conditions of the Mediterranean climate to study the effects of different seed mixture ratios (Berseem clover (BC100), annual ryegrass (AR100), BC80-AR20, BC60-AR40, BC40-AR60, BC20-AR80) on forage yield and quality characteristics of mixture. The experiments were conducted in a randomized complete block design with three replications during the growing season of 2020- 2021 and 2021-2022. Annual ryegrass sown as pure produced higher green forage yield than berseem clover sown as pure and the mixtures. In the mixture of berseem clover at 20% seed rate and pure annual ryegrass, higher hay yields were determined compared to the other mixtures. In terms of total LER, BC80-AR20 and BC20-AR80 mixtures were the two most advantageous mixtures, while the aggressivity value of annual ryegrass showed a positive value and became the dominant species. Pure sown berseem clover had lower ADF, NDF and higher crude protein content than pure sown annual ryegrass and other mixtures tested. According to these results, it can be said that berseem clover can be included in the mixture at low seed rates for high forage yield under rainfall conditions, while berseem clover can be grown as pure for high forage quality
A busca do ambiente terapêutico: desafios contemporâneos na era da tecnologia
Authors: Cavalcanti Ana Carla Dantas
Published: October 2024

Às 05:53, dei início à redação deste editorial enquanto me encontrava em um hospital privado, acompanhando minha mãe, diagnosticada com demência e pneumonia. Perplexa diante da perda do tão prezado "ambiente terapêutico" defendido por Florence Nightingale, senti a urgência de abordar este tema antes mesmo do amanhecer, temendo perder o ímpeto motivacional que me impulsionava.
Kamusallık Kavramı Üzerinden Kamusal Alanı ve Kamusal Alan Niteliklerini Tanımlamak
Authors: Uysal Fulay
Published: October 2024

Kamusallık ve kamusal alan olgusu tarih boyunca kentlerin yaşanabilirliği ve canlılığı için önemli olmuştur. Kentler, insanların ortak faaliyetlerini içeren ve birlikte yaşamlarını paylaştıkları kamusal alanlar barındırır. Kamusal alan kavramı, farklı özellikleriyle çeşitli şekillerde tanımlanabilir ve anlamlandırılabilir. Bu çalışma, kamusallığın tanımlarını ve niteliklerini kavramsal ve deneysel açıdan değerlendirmekte ve kamusal alanın söylemsel – eylemsel ve kamusal yaşama ilişkin özelliklerini ortaya çıkartmaktadır. Bu tanımlardan yola çıkarak, mülkiyet, erişim ve kullanım özeliklerine bağlı değişkenlik gösteren, erişim ve kullanımı kontrollü, erişim ve kullanımı serbest kamusal alanlar açıklanmaktadır. Literatür taramasında farklı disiplinlerde tanımlanan kamusallık ve kamusal alan kavramları ele alınmaktadır. Kamusallık kavramı, kentsel kamusal alanın işlevleri üzerinden değerlendirilmekte ve başarılı bir kamusal alanın nitelikleri oluşturulmaktadır. Kamusal alanın nitelikleri fiziksel, sosyal, insan, toplum ve çevre ilişkileri nitelikleri baz alınarak incelenmektedir. Oluşturulan tanım ve nitelikler, kentsel planlamada hem teorik çalışmalar için hem de uygulama pratiği için önem taşımaktadır.
Clinical case of an atypical variant of Labbe's vein structure in a patient with pharmacoresistant temporal epilepsy
Authors: Shnyakin Pavel G. , Isaeva Natalya V. , Dmitrenko Diana V. , Roslavtseva Valeria V. , Usoltseva Anna A. , Ermilov Evgeniy A. , Medvedeva Maria K. , Trubkin Aleksei V. , Putilin Alexander V. , Loseva Anastasia S.
Published: October 2024

Among the commonly recognised structural lesions that cause drug-resistant temporal lobe epilepsy, such as mesial temporal sclerosis, focal cortical dysplasia, benign intracerebral tumors, arteriovenous malformations and cavernous angiomas, researchers have recently noted other pathologies, such as, encephalocele. There are a number of publications on the connection between epilepsy and cerebral venous angiomas. However, there are no published cases of the influence of the abnormal structure and location of normal cerebral vessels on the development of epilepsy. This article presents a case of an atypically large and unusually located vein of Labbe that may have been involved in epileptogenesis and also complicated an anteromedial temporal lobectomy. Forced coagulation and excision of the Labbe vein during surgery did not lead to venous infarction and neurological deficit.
Variations in movement disorders in patients with acute ischemic stroke
Authors: Saikhunov Rustam M. , Danilova Tatiana V.
Published: October 2024

The article focuses on movement disorders following acute ischemic stroke. It explores how the localization of the infarct and the extent of brain damage influence the development of these disorders and the recovery of lost function. This knowledge is crucial for providing effective patient management. Clinical case studies are used to illustrate the different types of movement disorders seen in ischaemic stroke patients, including pyramidal tract damage, sensory deficits, ataxia and apraxia.
Development and psychometric assessment of the test “Predictive style”
Authors: Granitsa Alexander S. , Lotfullina Adelina R. , Perishivkina Vlada V.
Published: October 2024

BACKGROUND: Prognostic processes are an important link in adaptation to stressful events and resilience. The role of the features of prognostic abilities in various mental disorders is shown. We introduce and substantiate a new psychological construct, the “Predictive style”, reflecting the subjective importance of the forecasting process and the tendency to assess the favorability of predicted events.
AIM: To develop and conduct a psychometric assessment of the “Predictive style” test.
MATERIALS AND METHODS: A “Predictive style” test was developed, including 21 statements divided into 4 scales: excessive optimism, excessive pessimism, excessive forecasting and indifference to forecasts. The development of the test included the study of the external and internal validity, as well as the reliability of the methodology.
RESULTS: The measures of compliance with the test model were at a sufficient level: CFI=0.927; TLI=0.917; SRMR=0.0538; RMSEA=0.0497 (95% CI 0.0403–0.0589) and were performed on a new sample. All items correlated with their scales at a sufficient level. The reliability of the scales was in an acceptable range: Kronbach α=0.851–0.630. Retest reliability was confirmed after 2 months. Convergent validity was demonstrated by correlations with levels of optimism, pessimism, anticipation, predictive ability and coping strategies. Statistically significant differences were found between the groups of patients with neurotic mental disorders and those without psychopathology. Multiple linear regression demonstrated that the test scales were statistically significant predictors of anxiety and depression symptoms in the study participants. The results obtained confirm the criteria validity of the test under development.
CONCLUSION: The developed test has sufficient psychometric indicators and can be used in subsequent studies.
Study of the functioning of mirror neurons in normal conditions, in neurological and psychiatric diseases: a systematic review of the literature
Authors: Ragimova Aynur A. , Perevoznyuk Gleb S. , Volel Beatrice A. , Petelin Dmitry S. , Ponomareva Daria S. , Salamatin Mikhail I. , Batov Artyom A. , Feurra Matteo
Published: October 2024

The mirror neuron system is a fundamental brain system of the brain that provides the ability to understand the actions of others and plays a key role in motor learning and empathy. In this review, we have thoroughly examined the internal and external factors that influence the functioning of the mirror neuron system. Issues such as difficulties in interpreting the mu rhythm and its relationship to theory of mind, which are particularly salient when analysing the mirror neuron system in the context of mental illness, have been identified. The role of the mirror neuron system in the formation of various mental disorders and neurological diseases has been considered. Additionally, a promising direction for future research is highlighted — the study of the mirror neuron system in the context of Parkinson's disease, focusing on the peculiarities of the functioning of the dopaminergic system of the mirror neuron system under normal conditions and in the presence of pathology. Prospective directions for further research are suggested, including the analysis of the mu-rhythm, the role of mentalization, studying the mirror neuron system in mental and neurological diseases.
The phenomenon of “emptiness” in modern psychiatry
Authors: Mendelevich Vladimir D.
Published: October 2024

The article analyses a new psychopathological phenomenon of “emptiness” for classical psychiatry, which is compared with clinical manifestations of emptiness, boredom, apathy, and melancholy. A conclusion is made about the uniqueness of this symptom is drawn. The relationship between the phenomenon of “emptiness” and other diagnostically significant symptoms of borderline personality disorder (BPD) is examined, as is its influence on suicidal and self-harming behavior. It is argued that “emptiness” reflects the mechanism of dissociative depersonalization, and that the wide representation of dissociative symptoms within BPD in conjunction with the “emptiness” phenomenon makes it promising to consider BPD and its individual symptoms a “new hysteria”.
Pharmacokinetics of Single-dose CLX-155 and Metabolites in Female Balb/C Mice
Authors: York John , Kang Sophie , Dalton Ava , Tak Yearam , Boyette Natasha , Kandula Mahesh , Apparsundaram Subbu
Published: October 2024

Introduction: CLX-155 is a novel oral 5’-DFCR prodrug involving 5’-DFCR as an intermediate for generating 5-FU. Unlike capecitabine, CLX-155 undergoes esterase-mediated hydrolysis in the intestinal cells rather than the liver, leading to a different metabolic and pharmacokinetic profile. This study addresses the following research questions: 1) what is the single-dose PK of CLX-155, and 2) how does it compare to capecitabine? Methods: This study was a parallel, single-dose study with four treatment groups. Investigators randomized 48 female Balb/C mice into four treatment groups: CLX-155 at 250 mg/kg and 500 mg/kg and capecitabine at 500 mg/kg and 1000 mg/kg. Animals received oral treatment once. Investigators evaluated PK parameters via noncompartmental analysis using WinNonlin Version 7.0 (Certara, Princeton, NJ). Results: For CLX-155, the systemic exposure (Cmax and AUC0-t) of 5-FU, 5’-DFCR, and 5’-DFUR demonstrated proportionality to the administered dose. 5’-DFCR and 5’-DFUR showed a delayed Tmax compared to 5-FU. For capecitabine, the systemic exposure (Cmax and AUC0-t) of 5-FU, 5'-DFUR, and 5’-DFCR was less than dose proportional. CLX-155 demonstrated higher exposure at 500 mg/kg compared to capecitabine at the same dose. CLX-155 displayed marginally higher 5’-DFUR and 5-FU plasma AUC0-t in relation to capecitabine at equivalent 500 mg/kg doses. CLX-155 displayed marginally higher plasma AUC0-t of 5-FU and 5’-DFUR in relation to capecitabine at the equivalent doses of 500 mg/kg. Conclusion: CLX-155 and capecitabine experience rapid absorption following oral administration and conversion to 5’-DFCR, 5’-DFUR, and 5-FU. The results suggest the conversion of CLX-155 to its metabolites 5’-DFUR and 5-FU was more efficient than that of capecitabine. Such observations have suggested that administration of CLX-155 at a lower dose level is a possibility. CLX-155’s infusion-like conversion to its metabolites 5’-DFUR and 5-FU provided a unique PK profile that may explain its antitumor activity in animals at half the dose of capecitabine reported in the previous study.
Uso de ferritina como biomarcador en enfermedades reumáticas autoinmunes sistémicas: revisión de la literatura
Authors: Rivera-Martínez Wilfredo Antonio , Casanova-Valderrama María Eugenia
Published: October 2024

La ferritina sérica además de ser un biomarcador tradicional de las reservas de hierro se ha constituido en indicador de respuesta inflamatoria de uso cada vez más frecuente, especialmente en el contexto de las enfermedades reumáticas autoinmunes sistémicas que tienen una prevalencia cercana al 5 %, en las cuales múltiples biomarcadores se han utilizado para definir criterios clasificatorios, actividad, pronóstico y respuesta al tratamiento. Se realizó una revisión narrativa a partir de una búsqueda en agosto de 2022, en las bases de datos: Medline, ScienceDirect, SciELO, con el objetivo de revisar la evidencia sobre aplicabilidad y utilidad de evaluar ferritina sérica en estas enfermedades. El tamizaje en fiebre de origen desconocido, establecer riesgo de hiperuricemia y de crisis en gota, actividad de la enfermedad en Artritis reumatoide y Lupus eritematoso sistémico, y el pronóstico de los pacientes con enfermedades reumáticas autoinmunes sistémicas en enfermedad por coronavirus son los usos potenciales de la ferritina sérica en reumatología.
Sepsis de origen abdominal secundaria a perforación estercoral recto-sigmoidea: a propósito de un caso
Authors: Serrano-Lizarazo Juan Daniel , Ayala-Gutiérrez María Camila , Quintero-Gamboa Diana Clemencia , Pinto-Arias Andrea Juliana , Serrano-Pastrana Juan Paulo
Published: October 2024

La perforación estercoral es una ruptura del colon asociada a impactación fecal, rara y letal, con menos de 200 casos reportados globalmente. Predomina en la población geriátrica y se manifiesta principalmente con estreñimiento crónico. El objetivo del artículo es presentar el caso de una mujer adulta intermedia con antecedentes de estreñimiento crónico y enfermedad diverticular, que ingresó a urgencias con una semana de dolor abdominal generalizado, y evolucionó a abdomen en tabla, alteración en la conciencia y taquipnea. Se sospechó sepsis abdominal por lo que se llevó a una laparotomía de emergencia. Esta reveló pelviperitonitis fecal originada por fecaloma sigmoideo con perforación estercoral de 12 cm, manejada con sigmoidectomía, antibioticoterapia de amplio espectro y lavado peritoneal. La paciente evolucionó favorablemente y fue dada de alta. Este desafiante caso, desde el punto de vista quirúrgico y diagnóstico, destaca la complejidad de una patología poco común en un grupo etario atípico.
Luxación de rodilla asociada a trauma de ultra baja energía y obesidad: reporte de caso
Authors: De La Rosa Cuentas Alfredo Daniel , Gutiérrez-Gaspar Cristian Camilo , Vanegas-Carrillo Darwin Jeunner , Téllez-Gamarra Diego Alejandro
Published: October 2024

La luxación de rodilla es la pérdida de la relación articular femorotibial, asociada a lesiones de mínimo dos ligamentos mayores; ocurre en el 0,02 % de lesiones en ortopedia. El objetivo de este artículo es presentar el caso de una paciente adulta intermedia con obesidad grado I, quien presentó caída desde su altura, con trauma en rodilla derecha. La radiografía de ingreso evidenció luxación anteromedial en esta articulación, por lo cual es llevada a reducción cerrada e inmovilización y, posteriormente, se realiza radiografía posreducción, Doppler arteriovenoso y resonancia magnética encontrando desgarro del menisco lateral, ruptura de los ligamentos cruzado posterior, cruzado anterior, retináculo lateral y fractura de la cabeza del peroné. Este caso es significativo al tratarse de una luxación en trauma de ultra baja energía en un paciente con obesidad, que no es la presentación típica y resalta la importancia de la búsqueda activa de lesiones asociadas.
Carcinomatosis peritoneal secundaria a adenocarcinoma prostático: reporte de caso
Authors: Gómez-Fontalvo César Alfonso , Rodriguez-González Cristian Arturo , Villamizar-Jiménez Maria Alejandra , Sequea-Meneses David Mateo , Murcia-Cárdena Luis Felipe , Cadena-Sanabria Miguel Oswaldo
Published: October 2024

La carcinomatosis peritoneal es una entidad poco común y de mal pronóstico, evidenciada en metástasis principalmente de origen gastrointestinal y ovárico. Sin embargo, es infrecuente que se desarrolle por adenocarcinoma prostático. Se presenta el caso de un adulto mayor con síndrome constitucional asociado a ascitis maligna, de dos meses de evolución. La tomografía reveló múltiples lesiones peritoneales correspondientes a carcinomatosis peritoneal. En el tacto rectal, una próstata fija y pétrea con recesos bilaterales comprometidos. El antígeno prostático específico estaba marcadamente elevado. La biopsia de las lesiones peritoneales confirmó adenocarcinoma prostático avanzado, T4N0M1, estadio IVb, Gleason X. Se realizó bloqueo androgénico completo y el paciente continúa en seguimiento a los 24 meses. La carcinomatosis peritoneal por carcinoma prostático es un diagnóstico diferencial que debe plantearse ante ascitis y patología tumoral prostática, siendo la sospecha clínica y los estudios citoquímicos el inicio del abordaje secuencial para un diagnóstico oportuno, estadificación tumoral y pronóstico.
Az európai uniós szankciók eseményhatás-elemzéssel történő vizsgálata
Authors: Kiss Dorina , Fűrész Diána Ivett , Rappai Gábor
Published: October 2024

This study examines the impact of the European Union’s sanctions against Russia and the news about them on gas prices. Using the event study methodology, we primarily seek to answer whether the different types of news related to sanctions (any mention of the sanctions package, announcements of its content or adoption) impacted gas prices significantly and in differing ways. The 24 selected events were analysed using three different model variants (market model, GARCH, EGARCH) and four different (3-, 5-, 10-, and 15-day) window lengths. Our results confirmed our hypothesis that the mere mention of sanctions has an upward effect on gas prices, similar to the other two types of news.
A hazai gyermekvédelmi rendszer fejlesztésében rejlő potenciális gazdasági hasznok
Authors: Szombath Kitti , Varga Erzsébet Teréz
Published: October 2024

The study approaches child protection involvement from an economic perspective, and is thus a niche study in the Hungarian literature. It seeks to quantify the social benefits to society of mitigating the negative impact of involvement in the provision of child protection, and the maximum return on investment in the child protection system for a given payback period and discount rate. As in international research, the evaluation of the project is based on a cost-benefit analysis of the increase in educational attainment. The social benefit is estimated by determining the number of people affected and the social benefit per person affected, and the social discount rate is determined using two types of elasticity estimates. The results suggest that a greater allocation of public resources to child protection provision not only benefits the individuals concerned, but can also result in a positive net present value investment for society as a whole.
A Comparative Evaluation of Bifilac Clausi Vs Enterogermina and Other Selected Brands for Probiosimilarity
Authors:   Department of Pharmaceutical Biotechnology, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Ooty, The Nilgiris, Tamil Nadu, India, Rajeshkumar Raman
Published: October 2024

Purpose: To compare the qualitative and quantitative parameters of various Bacillus clausii brands that are available in the Indian market with the International reference product, Enterogermina. Study Centre: JSS College of Pharmacy, Ooty Study Period: 06th Nov 2022 to 30th Dec 2022 Methods & Materials: Various parameters like total spore count, number of strains isolated (based on their sensitivity/ resistance pattern to antibiotics), pH & Transmittance, antibiotic resistance test, microbial purity, DNA sequencing and species identification were tested with various Bacillus Clausii brands that are available in Indian market and were compared with the International reference product, Enterogermina. Results: Only Bifilac Clausi (Bacillus clausii - TIL 19T, TIL 21C, TIL 28S, TIL 30R) a product of Tablets (India) Limited passed all the qualitative and quantitative parameters in terms of assay, same number of strains (4 strains), taxonomical similarity, pH and suspension clarity, as well as resistance/sensitivity pattern to commonly used antibiotics. Conclusion: Based on the results of the testing of various Bacillus clausii formulations, we conclude that only Bifilac Clausi (Bacillus clausii - TIL 19T, TIL 21C, TIL 28S, TIL 30R) showed a similarity to the International reference product, Enterogermina. Hence Bifilac Clausi was found to be probiosimilar to Enterogermina and is a viable alternative to Enterogermina to provide similar probiotic benefits. Keywords: [Probiosimilar, Bacillus clausii formulation, Indian market, Qualitative & Quantitative parameters, 16S RNA sequence]
Peripheral nerve block (Tetra block) - an effective alternative anesthesia for patients undergoing fractured femur neck surgery with recent myocardial infarction and low ejection fraction: a case report
Authors:   MBBS, MD Anaesthesiology, FICM, Senior Consultant Anaesthesiologist, Department of Anaesthesiology, St.Thomas Hospital Chethipuzha, Changanassery, Kerala-686104, Ambooken Dr Anu
Published: October 2024

The fractured neck of the femur (NOF) is a common injury among the elderly population1 . Ischemic heart disease (IHD)is a common comorbid condition in these patients, and recent myocardial infarction (MI)adds a unique challenge for the anesthesiologist1 . The best timing for the surgery is known to be the day of admission or the day after admission. However, this poses a challenge due to patients possibly being on antiplatelet or anticoagulant therapy, which means central neuraxial blockade is not an option1 . General anesthesia (GA) for these patients can lead to cardiovascular and respiratory instability due to associated low ejection fraction (EF)2 . Hemodynamic fluctuations related to anesthesia can be harmful. In this case study, a patient with a NOF fracture and a recent MI with a low EF underwent hemiarthroplasty. The procedure used a peripheral nerve block (PNB) alongside sedation as the sole anesthetic technique. The patient remained stable throughout the surgery and in the postoperative period. Keywords: Neck of femur fracture, Myocardial Infarction, Peripheral Nerve Block, Tetra block, Locoregional, Ejection Fraction.