bluuebunny/crossref_metadata_2025 huggingface dataset:
Carbonyl Posttranslational Modification Associated With Early-Onset Type 1 Diabetes Autoimmunity
Authors: Yang Mei-Ling , Connolly Sean E. , Gee Renelle J. , Lam TuKiet T. , Kanyo Jean , Peng Jian , Guyer Perrin , Syed Farooq , Tse Hubert M. , Clarke Steven G. , Clarke Catherine F. , James Eddie A. , Speake Cate , Evans-Molina Carmella , Arvan Peter , Herold Kevan C. , Wen Li , Mamula Mark J.
Published: June 2022

Inflammation and oxidative stress in pancreatic islets amplify the appearance of various posttranslational modifications to self-proteins. In this study, we identified a select group of carbonylated islet proteins arising before the onset of hyperglycemia in NOD mice. Of interest, we identified carbonyl modification of the prolyl-4-hydroxylase β subunit (P4Hb) that is responsible for proinsulin folding and trafficking as an autoantigen in both human and murine type 1 diabetes. We found that carbonylated P4Hb is amplified in stressed islets coincident with decreased glucose-stimulated insulin secretion and altered proinsulin-to-insulin ratios. Autoantibodies against P4Hb were detected in prediabetic NOD mice and in early human type 1 diabetes prior to the onset of anti-insulin autoimmunity. Moreover, we identify autoreactive CD4+ T-cell responses toward carbonyl-P4Hb epitopes in the circulation of patients with type 1 diabetes. Our studies provide mechanistic insight into the pathways of proinsulin metabolism and in creating autoantigenic forms of insulin in type 1 diabetes.
Impact of Static Progressive Stretch on Range of Motion After Total Knee Replacement in Patients with Haemophilia
Authors: Pompe Borut , Filipidis Simona , Dovč Petra
Published: June 2022

Background: Haemophilic arthropathy is often associated with a loss of range of motion. Total knee arthroplasty is an effective treatment option for patients with end-stage haemophilic arthropathy of the knee. However, even after arthroplasty, the range of motion sometimes remains insufficient.Objective: To evaluate static progressive stretch as a treatment method for haemophilic patients with decreased range of motion after total knee arthroplasty.Methods: Static progressive stretch was used to improve range of motion in patients with a postoperative extension lag of more than 10° and flexion of less than 80°. A total of 7 knees were treated for a mean of 21.7 weeks.Results: Statistically significant increases in range of motion and in Knee Society Score were observed when comparing pre-treatment and post-treatment values.Conclusions: Static progressive stretch using an orthotic device could be a successful adjuvant method for treating joint stiffness in patients with haemophilia after total knee arthroplasty.
LAY ABSTRACTHaemophilic arthropathy often results in loss of range of motion. Total knee arthroplasty is an effective treatment option for patients with end-stage haemophilic arthropathy of the knee. However, despite arthroplasty, the range of motion is sometimes insufficient. Static progressive stretch using special knee orthoses is an adjunct technique to traditional physiotherapy, intending to restore functional range of motion and decrease knee stiffness and pain. The aim of this study was to evaluate static progressive stretch as a treatment method for hemophilia patients with decreased range of motion after total knee arthroplasty.
Virtuális valóság és haderő – katonai alkalmazási lehetőségek
Authors: Németh András , Virágh Krisztián
Published: June 2022

Bár a virtuális valóság nem a 21. század találmánya, a technológia csak az elmúlt évtizedben érte el azt a fejlettségi szintet, amely megteremtette szélesebb körű elterjedésének technikai feltételeit. Az utca embere ma még csak többnyire filmekben, illetve VR vidámparkokban, vagy szórakoztató központokban találkozhat fejlettebb virtuális élményt kínáló megoldásokkal, ugyanakkor néhány százezer forintos befektetéssel már az otthonunkban is megtapasztalhatjuk a technológiában rejlő lehetőségeket. A katonai kiképzés területén már akár évtizedek óta a VR számos elemét használják, a komplex, magas valóságérzetet keltő megoldások integrációja mégis további, nagy dinamikával fejlődő lehetőséget kínál a hazai kiképzés rendszerének reformjára és folyamatos modernizálására. Jelen tanulmányunkban a VR kialakulása, és fejlődésének fontosabb állomásai kerülnek bemutatásra.
Az Ejder Yalçin Block 4+ verzió harcjárművek kommunikációs integrációja nemzetközi környezetben
Authors: Dóczi István
Published: June 2022

A szerző beszámol a Zrínyi Honvédelmi és Haderőfejlesztési Program keretében megvalósított Nurol Makina Ejder Yalçin harcjárművek híradókommunikációs hardware-integrációs munkálatairól. Az eszközök beépítését követően, a Gidrán összkerékhajtású, robbanásálló, többfeladatú páncélozott harcjárművek alkalmassá váltak arra, hogy hazai és nemzetközi környezetben, gyakorlatokon és missziókban egyaránt bizonyítsák képességeiket.
Algerian EFL Secondary School Students’ Attitudes towards Using Group Investigation Cooperative Learning Model for Teaching English School Projects
Authors: Belmekki Asma , Baghzou Sabrina
Published: June 2022

To help secondary school learners overcome the difficulties they encounter when working on their English school projects, we have used one of the cooperative learning techniques Group Investigation (GI), based on the Sharan and Sharan (1992) Model. After applying the model, we wanted to determine the students’ attitudes towards project work and the new teaching method. Thus, this research study aimed to measure the effect of the Group Investigation technique on the students’ attitudes towards English projects in general and Group investigation in particular. We hypothesize that the GI model will positively affect the students’ attitudes and motivation towards their school English projects. To reach the aim of this descriptive quantitative study, we developed a four-section attitude scale, and the current situation is described by analyzing the data obtained from the applied scale. The study’s sample is a focus group of 21 students studying at Elhachemi Bouzidi Secondary School in Khenchela, Algeria. The research data were collected, coded, and analyzed using the statistical package for social sciences (SPSS 24.0 Packet program). The researcher also used Cronbach’s Alpha to measure the scale’s reliability. The research findings reveal that the applied model positively influenced the students’ attitudes, project performances, motivation, target language use, and cooperation.
MODEL OF WOMEN EMPOWERMENT IN THE FISHERMAN AREA OF BILAH HILIR LABUHANBATU REGENCY
Authors: Irmayani Tengku
Published: June 2022

This study aims to describe the model of women's empowerment in fishing areas. This research method uses a qualitative approach. The research was conducted through interviews, field observations, and Focus Group Discussions (FGD) to collect the required data. Informants in this study were representatives from the Department of Marine Affairs and Fisheries and the Office of Cooperatives and Small and Medium Enterprises, as well as women in the fishing area of Bila Hilir. The research location is Bilah Hilir Village, Labuhanbatu Regency, North Sumatra Province which is one of the fishing villages with the community's economic level far below the poverty line. The results showed that low income caused many fishermen's children to drop out of school, and become entangled with moneylenders. The government's lack of attention to developing the fishermen's economy has made women in this fishing area just give up. This study concludes that there has been no empowerment carried out by the Labuhanbatu Regency government for women in the Bila Hilir fishing area.
Semi-canned fish pates with immunomodulation components
Authors: Lavruhina Elizaveta Vasilyevna , zarubin Nikita Yurievich , Kharenko Elena Nikolaevna , Bredihina Ol'ga Valentinovna , Arkhipov Leonid Olegovich
Published: June 2022

In accordance with the Strategy for improving the quality of food products in the Russian Federation until 2030, the priority is scientific research in the field of nutrition of the population, including in the field of prevention of the most common non-infectious diseases and the development of production technologies aimed at improving the quality of food products, as well as promoting the principles of healthy nutrition. One of the ways to increase and promote them is the development of products containing immunomodulating components, which refers to promising areas for strengthening the immune defense of the human body. There are presented the formulations of finished food products (fish pates) containing components with immunomodulatory properties, such as fat-soluble vitamins A and D, Omega-3 polyunsaturated acids, copper (Cu) and the prebiotic inulin. Optimal formulations have been designed and the technology of the products has been developed. Analyses of the quality indicators of the developed finished products allowed us to establish its high nutritional, in particular biological value: semi-canned food contains fat-soluble vitamins A (386.50 - 443.31 mcg/100 g) and D (10.39 - 12.96 mcg/100 g), polyunsaturated fatty acids of the Omega-3 group (1.02 g - 1.35 g), essential microelement copper (0.86 - 1.21 mg/100 g), as well as dietary fibers, in particular inulin (3.12 - 3.49%), the amount of which will satisfy the daily physiological need by more than 15%, which allows to recommend them as natural functional food products with immunomodulating components.
Methods of determining stocks of commercial fish species and fish products in inland water bodies and estimation of their reliability (case of Kenozero National Park)
Authors: Dvoryankin Gennadiy
Published: June 2022

More than 95% of fish on the territory of the Kenozero National Park are caught in the Park's two largest lakes - Kenozero and Lekshmozero. There are presented the results of assessing the stocks of commercial fish species and fish products of these two lakes obtained in the course of fisheries monitoring using direct methods of ac-counting for the fish abundance. The data on fish ichthyomass and fish products analyzed by using the indirect methods are also given, the comparative analysis is made. It has been found that the indirect methods applied even for the same water body show

a large spread of the final results varying tenfold in some cases. This is due to the fact that the used in these methods

limited biotic and abiotic characteristics of the water bodies don’t cover all the significant indices that affect the formation of the ichthyomass and fish products in this water body. A conclusion is made about a careful ap-proach to the application of indirect methods for assessing the fishery characteristics of the water body. The research on the effectiveness and reliability of indirect methods is proposed to be continued with involving a larger number of parameters. At present, when preliminary fisheries management assessment of unexplored water bodies of the taiga zone of the northern region

it is recommended to use the zonal index as the most universal one.
Force performance of trawl system – V: predictive modeling
Authors: Nedostup Alexander Alekseevich , Razhev Alexey Olegovich , Nasenkov Pavel , Konovalova Karina
Published: June 2022

Predictive modeling (PM) of the trawl system (TS) is a complex, interdisciplinary and cognitive representation of the TS links. Predictive modeling of the vehicle predicts its operational parameters in various conditions (transition, etching of warriors, trawling, hauling of trawl and other processes). It is also possible to process the data of experiments and numerical simulations on the basis of PM together, which is not compatible with mathematical and physical simulations. In the process of designing a vehicle, it is often necessary not only mathematical, physical, but also their predictive modeling. By TS is meant the trawl itself (cable-net section) with rigging, cable equipment, trawl boards, warp, connecting elements, fan winch (trawl winch), rope net drum, sensors (travel horizon, trawl bag filling, strains in the cords, the length of the cords, the opening of the mouth of the trawl, etc.). By predictive modeling (hereinafter referred to as PM) we will mean multiscale interdisciplinary processes occurring in the TS. Predictive modeling of the vehicle is one of the important components of the virtual reality of the vehicle operation and an important module of the software and hardware simulator Tral. There is set the task

of predictive modeling of the characteristics of rope-rope products from which rope-net fishing tools of the TS are made. A mathematical model of predictive modeling of structural, geometric and power characteristics of rope-rope products is proposed. Based on the theory of similarity, it is possible to predict the values of the output data with fewer characteristics of rope products. The proposed method allows, without conducting experiments on ropes of large diameter, to determine their basic physical and mechanical properties, those geometric and power characteristics that are necessary for modeling new elements of the vehicle.
Structural and functional study of fish kidneys under ecological monitoring and in aquaculture
Authors: Egorova Vera Ivanovna , Kryuchkov Victor Nickolaevich , Volkova Irina Vladimirovna , Seydalieva Leila Kamidullaevna
Published: June 2022

The intense anthropological impact on the ecosystems makes it necessary to monitor the state of populations of different fish species from different points of view. Health of aquatic animals, including fish, is an informative indicator of the quality of the environment, since physical and chemical changes in water, if they go beyond the optimum, cause definite reactions in the fish body. There are summarized the results of studying the kidneys of cyprinid fish species from the natural habitats of the lower reaches of the Volga and Kigach rivers and the Northern Caspian, as well as those cultivated in pond farms. The detected violations of mesonephros were described depending on localization of the pathological process. It has been shown that pathological changes are found in all structures of the kidney: in the interstitial, renal corpuscle, convoluted muscles. A change in the rheological properties of blood, glomerular changes up to atrophy of capillary loops, dystrophic changes in the tubular epithelium were found. An original system for assessing the condition of fish kidneys is proposed. Reactions in the body of hydrobionts are a consequence of the combined effects of environmental factors and natural physiological processes. The changes detected in the organ structure make it possible to assess the environmental impact on fish. Histopathological changes in vital organs, in particular, in mesonephros, are valuable indicators for assessing the consequences of negative environmental influences. Using not only qualitative, but also quantitative characteristics of mesonephros can contribute to introduce the quantitative methods in ecological and morphological studies of fish.
EDUKASI DAN LITERASI MENGENAI PERAN SISWA SEKOLAH DASAR TERHADAP WISATA PERKOTAAN DI KOTA BANDUNG
Authors: Amalia Rosaria Mita , Sari Sujatna Eva Tuckyta , Heriyanto Heriyanto , Krisnawati Ekaning , Pamungkas Kasno
Published: June 2022

Indonesia memiliki potensi pariwisata yang sangat besar dengan keragaman keindahan alam serta kekayaan budaya yang terdapat di dalamnya merupakan salah satu kekuatan bagi Indonesia untuk mengembangkan sektor pariwisatanya. Kota Bandung sebagai salah satu kota wisata di Propinsi Jawa-Barat mampu menjadi daya tarik destinasi wisata dengan keberagaman tempat wisata yang ditawarkan yaitu wisata alam, wisata buatan, wisata belanja, dan wisata kuliner. Kesemua jenis-jenis wisata tersebut dapat dinikmati oleh wisatawan domestik dan mancanegara. Dengan kekayaan dan keragaman tersebut, siswa-siswi Sekolah Dasar (SD) memiliki peran penting sebagai salah satu penikmat dan pelaku pariwisata untuk tetap menjaga kelestarian serta kelangsungan tempat-tempat wisata tersebut (actors of sustainable tourism). Karena itulah penting bagi mereka mendapatkan edukasi mengenai peran tersebut sehingga tingkat literasi serta kepedulian mereka terhadap tempat-tempat wisata khususnya di Kota Bandung dapat terus meningkat. Adapun peran yang dapat mereka jalankan adalah; (1). menjaga kebersihan dan keindahan tempat wisata, (2). tidak makan di tempat wisata kecuali di tempat makannya, (3). membuang sampah pada tempatnya, (4) mengajak keluarga, saudara, teman dan sahabat untuk menjaga lingkungan, serta (5). menjadi siswa sadar wisata yang ramah terhadap wisatawan dan lingkungan.
OPTIMALISASI PENJUALAN BAHAN PANGAN OLEH PETANI DAN UMKM DENGAN MEMANFAATKAN TEKNOLOGI DIGITAL
Authors: Darodjat Rafan , Utarie Fatmi
Published: June 2022

Berkembangnya teknologi menjadikan pola kehidupan masyarakat berubah, penjualan bahan pangan memasuki era baru yang dilakukan secara online. Hal ini tentunya menjadi tantangan bagi petani dan UMKM untuk mengoptimalkan penjualan dengan memanfaatkan platform di smartphone dan komputer. Tujuan dari kegiatan Pengabdian Kepada Masyarakat yang dilaksanakan pada tanggal 10 Juli 2021 sampai dengan 10 Agustus 2021 adalah untuk meningkatkan kewirausahaan petani dan UMKM melalui teknologi digital supaya dapat menjual produk pertaniannya secara mandiri. Metode Pendekatan terhadap pengabdian ini melalui kombinasi 2 (dua) metode, yaitu sebagai berikut: (1) Substitusi Ipteks dan pendidikan masyarakat dengan in-house training. Hasil pengabdian, yaitu pengoptimalan penjualan bahan pangan dengan memanfaatkan platform: situs, jejaring sosial, lokapasar, dan aplikasi pesan. Untuk penggunaan platform yang tepat dilakukan pemetaan berdasarkan klasifikasi kuantitas penjual dan memilih aplikasi yang tingkat penggunanya besar.
PELATIHAN PEMBUKUAN SEDERHANA DAN PEMASARAN PRODUK BAGI USAHA RUMAH TANGGA SUSU SAPI PERAH
Authors: Babulu Natalia Lily , Kase Marce Sherly , Manane Desmon Redikson
Published: June 2022

Pelatihan Pembukuan Sederhana dan Pemasaran Produk bagi Usaha Rumah Tangga Susu Sapi Perah di Desa Mandeu Kecamatan Raimanuk,Kabupaten Belu-NTT. Kegiatan pengabdian pada masyarakat ini akan difokuskan pada usaha rumah tangga. Salah satu usaha rumah tanggan memiliki 8 ekor ternak sapi perah yang terdiri dari 3 ekor jantan dan 5 ekor betina. Berdasarkan pengamatan penulis, industri usaha rumahan ini memiliki banyak keterbatasan, antara lain sebagai berikut : Pembukuan yang dilakukan belum sesuai dengan standar pembukuan yang benar dan Pemasaran hasil produksi susu sapi belum dilakukan secara optimal. Tujuan dari pada pengabdian pada masyarakat ini adalah memahami tata cara pembukuan yang baik bagi pelaku usaha rumahan susu sapi dan memperluas lagi pemasaran susu sapi di setiap daerah dan memperbaiki kemasan yang ada.Hasil yang didapatkan peserta dari kegiatan pengabdian kepada masyarakat ini antara lain dapat membantu tercapaianya kesadaran bagi pelaku usaha rumah tangga akan pentingnya pembukuan sederhana dan pemasaran produk usaha rumah tangga susu sapi perah.
PELATIHAN DAN PENDAMPINGAN PENULISAN KARYA ILMIAH PADA MAHASISWA ANGGOTA FORDIS
Authors: Rizqi Fikriana Mahar , Wangi Maya Sekar , Widiyowati Estu
Published: June 2022

Fordis merupakan suatu forum diskusi yang dibentuk tahun 2020. Forum ini beranggotakan mahasiswa Ilmu Komunikasi dengan tujuan untuk membentuk dan menjaga 3 tradisi mahasiswa yakni tradisi membaca, menulis dan berdiskusi di Universitas Slamet Riyadi (Unisri). Ketiga tradisi tersebut penting karena memberikan mahasiswa posisi sebagai pengawas dengan mengekspos kebijakan penguasa dari kacamata mahasiswa dan teori-teori. Fordis setidaknya telah ikut serta dalam mewujudkan dan menjaga tradisi membaca dan diskusi. Anggota Fordis ingin mengembangkan hasil diskusi yang selama ini dilakukan ke dalam karya tulis ilmiah agar bisa dipublikasikan. Permasalahan mereka ada di kurangnya pengetahuan dan kemampuan dalam kepenulisan. Solusi yang ditawarkan atas permasalahan tersebut adalah dengan proses edukasi dengan metode pelatihan dan pendampingan karya tulis ilmiah selama enam bulan. Tujuan dari pelatihan ini adalah membantu anggota Fordis agar dapat menggunakan kemampuan dalam bidang penulisan karya ilmiah dalam kehidupannya sebagai civitas akademika, berupa proposal, esai dan jurnal. Hasilnya adalah mahasiswa mampu membuat proposal Program Kreativitas Mahasiswa Wira Desa dan esai yang dipublikasikan. Program ini bisa dikatakan berhasil karena mampu menghasilkan luaran karya ilmiah berupa proposal dan esai. Adapun jurnal belum berhasil terealisasikan sehingga diharapkan program ini bisa dilanjutkan di tahun berikutnya.
Konseling Kelompok Untuk Meningkatkan Efikasi Diri Penyintas Covid-19
Authors: Darmawansyah  , Rufaidah Anna , Nisa Alfatin
Published: June 2022

Self-efficacy is one of the important factors in healing the Covid-19 infection. In this case, group counseling was considered capable of increasing the self-efficacy of Covid-19 survivors. The aim of this study was to determine whether group counseling was able to increase the self-efficacy of Covid-19 survivors. This research was carried out using a quantitative approach with the type of experiment. The design used was the one group pretest-posttest design. The sample in this study was drawn randomly with a total of 10 people. Self-efficacy was measured using the GSE (General Self-efficacy) instrument. Data were analyzed using sign test. The results shown that group counseling was able to increase the self-efficacy of Covid-19 survivors. This increase further strengthens that counseling services can be used to help psychological barriers related to the Covid-19 pandemic.
Correlation of Mother’s Education Level with College Student Leadership Ability
Authors: Supriyono Agus , Maharani Diandra Shafira , Nengsih Wahyu
Published: June 2022

Penelitian ini mengkaji hubungan antara kemampuan kepemimpinan mahasiswa dengan tingkat pendidikan ibu. Kepemimpinan merupakan suatu kemampuan atau keterampilan yang harus dimiliki setiap orang. Dimana meliputi kemampuan seseorang untuk mengenali, mengontrol, dan mengatur emosi dan perasaan, baik perasaan sendiri maupun perasaan orang lain. Hal ini diperlukan untuk memecahkan dan menyelesaikan suatu masalah dengan tepat. Penelitian ini bertujuan untuk mengetahui perbedaan jiwa kepemimpinan siswa dilihat dari perbedaan tingkat pendidikan ibu. Penelitian ini menggunakan metode kuantitatif dan analisis deskriptif. Pengumpulan data dan dokumen dilakukan dengan menggunakan kuesioner yang dibagikan kepada mahasiswa dengan jumlah responden sebanyak 76 mahasiswa dari berbagai universitas. Desain penelitian ini adalah penelitian korelasional. Subyek penelitian ini adalah mahasiswa dengan mempertimbangkan tingkat pendidikan ibunya. Hasil penelitian ini menunjukkan hasil yang signifikan dari data yang kami peroleh
Global environmental governance, human rights and socio-state capabilities in Latin America
Authors:   Professor-researcher, University of Guadalajara (Mexico), Hincapié Sandra ,   member of the National System of Researchers of the National Council of Science and Technology (CONACYT), level 2
Published: June 2022

This article is a comparative study of the socio-state capabilities developed in the processes of institutionalising protected natural areas (PNAs) in Latin America within the framework of their interdependence with global governance processes and with reference to the role of human rights. From an approach that combines the analysis of multilevel collective action with process monitoring, this work traces national and multilateral institutional trajectories; analyses the main dynamics in the delimitation of protected natural areas in the countries in the region with critical biodiversity; and explores the possibilities for new agreements on the global agenda.
Praktyczne aspekty zastosowania lakozamidu u pacjentów z padaczką
Authors: Kopka Marcin
Published: June 2022

Lakozamid to lek przeciwpadaczkowy III generacji zaaprobowany do leczenia napadów ogniskowych z wtórnym uogólnieniem lub bez niego jako monoterapia i terapia dodana. Ogólnie jest dobrze tolerowany i ma niski potencjał interakcji lekowych, w tym z lekami antykoncepcyjnymi. Lakozamid jest wartościową opcją terapeutyczną u chorych z nowo zdiagnozowaną padaczką.
Mebeweryna w leczeniu zespołu jelita nadwrażliwego – skuteczność i bezpieczeństwo terapii
Authors: Gąsiorowska Anita
Published: June 2022

Zespół jelita nadwrażliwego jest przewlekłym, często nawracającym i bardzo rozpowszechnionym zaburzeniem interakcji mózg–jelito. W praktyce klinicznej zespół jelita nadwrażliwego charakteryzuje się przewlekłymi bólami brzucha i zaburzeniami rytmu wypróżnień. Mebeweryna jest muskulotropowym środkiem rozkurczowym o bezpośrednim działaniu na mięśnie gładkie przewodu pokarmowego, który łagodzi skurczowe bóle brzucha, nie zaburzając prawidłowej motoryki jelit. W artykule przedstawiono aktualne dane oceniające skuteczność i bezpieczeństwo stosowania mebeweryny w zespole jelita nadwrażliwego na podstawie systematycznego przeglądu literatury opublikowanego w 2022 r.
Ból zapalny w narządzie ruchu
Authors: Malec-Milewska Małgorzata
Published: June 2022

Uszkodzenie tkanek na skutek urazu lub procesu chorobowego powoduje uwolnienie z nich kaskady mediatorów prowadzących do rozwoju stanu zapalnego, procesów sensytyzacji struktur układu nerwowego, a w konsekwencji do powstania zapalnego komponentu bólu. Ból zapalny stanowi konsekwencję obronnej reakcji organizmu. Komponent bólu zapalnego występuje w zespołach bólu zarówno ostrego, jak i przewlekłego. Najczęściej ból zapalny dotyczy narządu ruchu i wiąże się z chorobą zwyrodnieniową stawów lub ma postać bólów dolnego odcinka kręgosłupa. Ból zapalny w narządzie ruchu charakteryzuje się brakiem poprawy po odpoczynku (tym różni się od bólu somatycznego przeciążeniowego, mechanicznego) i nasilaniem się w nocy, zwłaszcza w jej drugiej części. Ze względu na złożony patomechanizm bólu zapalnego jego leczenie musi mieć charakter multimodalny, a odpowiednio dobrana, kontekstowa farmakoterapia jest jednym z kluczowych elementów leczenia.
Arypiprazol w praktyce klinicznej
Authors: Dudek Dominika
Published: June 2022

Arypiprazol jest lekiem przeciwpsychotycznym II generacji, który ma podwójne działanie na receptory D2 – antagonistyczne i agonistyczne. Jest obecny na polskim rynku od kilkunastu lat, a od kilku – równieżw postaci iniekcji o przedłużonym uwalnianiu oraz iniekcji o szybkim uwalnianiu, stosowanych u pacjentów z ostrym pobudzeniem psychotycznym. Skutecznie działa w przypadku wystąpienia zaburzeń metabolicznych lub hiperprolaktynemii po innych lekach przeciwpsychotycznych, jak również w przypadku utrzymujących się objawów negatywnych. Charakteryzuje się dobrą tolerancją i korzystnym profilem bezpieczeństwa u pacjentów ze współistniejącymi chorobami somatycznymi.
Racekadotryl w leczeniu ostrej biegunki u dzieci: co mówią dane naukowe?
Authors: Szajewska Hanna
Published: June 2022

Ostra biegunka infekcyjna, czyli nieżyt żołądkowo-jelitowy (gastroenterocolitis), pozostaje jedną z częstych chorób wieku dziecięcego. Odwodnienie w przebiegu ostrej biegunki jest najczęstszym i jednym z najpoważniejszych powikłań. Podstawę leczenia stanowi więc stosowanie doustnych płynów nawadniających (lub nawadnianie dożylne, w zależności od stopnia odwodnienia). Doustne płyny nawadniające nie wpływają jednak na czas trwania i nasilenie biegunki, stąd zainteresowanie farmakoterapią. Racekadotryl jest lekiem o działaniu antysekrecyjnym, który wywiera działanie poprzez hamowanie enkefalinaz. W artykule omówiono aktualne dane dotyczące roli racekadotrylu w leczeniu ostrej biegunki u dzieci.
Citalopram i jego miejsce w praktyce klinicznej
Authors: Misiak Błażej
Published: June 2022

Citalopram to lek z grupy selektywnych inhibitorów wychwytu zwrotnego serotoniny. Został zarejestrowany do leczenia depresji, jednakże szereg badań wskazuje na możliwości jego zastosowania również w leczeniu niektórych zaburzeń lękowych oraz zaburzenia obsesyjno-kompulsywnego. Warto pamiętać, że w pewnych sytuacjach klinicznych zastosowanie citalopramu może okazać się optymalnym postępowaniem. W artykule przedstawiono historię trzech pacjentów, u których zastosowanie citalopramu okazało się skutecznym podejściem do leczenia depresji, które pozwoliło na uniknięcie potencjalnych działań ubocznych związanych ze stosowaniem leków przeciwdepresyjnych. Opisy przypadków przedstawiono w szerszym kontekście istniejącego stanu wiedzy dotyczącego farmakoterapii depresji.
Clinical presentation and treatment of lymphoma in companion rats (Rattus norvegicus; 2008–2020)
Authors: Faye-Fierman Sarah , Gardhouse Sara , McCready Julianne E. , Appleby Ryan , Hocker Samuel E.
Published: June 2022

OBJECTIVE

To describe the clinical presentation, treatment, and treatment outcomes for companion rats (Rattus norvegicus) diagnosed with lymphoma.

ANIMALS

All rats that presented to the exotics service and underwent postmortem examination during the time period of 2008 through 2020 were evaluated.

PROCEDURES

The medical records of 35 rats were evaluated for an ante- or postmortem diagnosis of lymphoma. Cases with a diagnosis of lymphoma were further reviewed for signalment, presenting complaint, clinical signs observed on physical exam, diagnostic testing performed, and treatments administered. Postmortem gross and histologic findings were reviewed.

RESULTS

7 out of 35 rats were diagnosed with lymphoma, either ante-mortem or postmortem. The most common presenting complaint that was present in all rats with lymphoma was respiratory abnormalities. Five out of 7 rats had radiographs performed, all of which had abnormalities noted in the thoracic cavity including pulmonary nodules, cranial mediastinal widening, or alteration to the cardiac silhouette. Diagnosis via cytologic aspirates was performed in 2 cases and each was diagnostic for lymphoma; however, even with treatment, survival time following initiation of chemotherapy was short (less than or equal to 24 days). The definitive diagnosis in the remainder of the cases was via necropsy.

CLINICAL RELEVANCE

Results suggest that lymphoma is a common neoplastic disease in rats and a thorough diagnostic work-up is indicated in any rat that presents for general malaise or respiratory signs.
Investigation of the Performance of Cotton/Polyester Blend in Different Yarn Structures
Authors: Babaarslan Osman , Shahid Md Abul , Okyay Neslihan
Published: June 2022

The demand for polyester fiber is increasing gradually day by day. Because of its good strength, low manufacturing cost, and ease of modification, polyester fiber has distinct characteristics, whereas cotton is well known for its comfort. Blending these fibers improves the performance of yarns. In this study, cotton/polyester was blended in different ratios to evaluate yarn performance. Three groups of yarn: rigid, core, and dual-core-spun, have been produced to examine the yarn’s performance. From the study, it has been found that increasing the polyester blend ratio increases the yarn strength and elongation but decreases the yarn unevenness and imperfections. Among the group, having more core components decreases yarn strength, unevenness, and imperfection but increases elongation. From the statistical analysis, except strength, all other properties have good interaction on yarn type and blending ratio. Pearson correlation also indicated that elongation and hairiness have a good correlation with yarn type where, except for hairiness, all other properties have shown a strong positive correlation on blending ratio.
Comparison of a system expansion and allocation approach for the handling of multi-output processes in life cycle assessment – a case study for nano-cellulose and biogas production from elephant manure
Authors: Krexner Theresa , Kral Iris , Gronauer Andreas , Medel-Jiménez Francisco Javier , Bauer Alexander
Published: June 2022

The handling of multi-outputs in life cycle assessment (LCA) is a controversial topic in both LCA application practice and the literature. Although there is a prescribed hierarchy of how to deal with multi-outputs, which favors system expansion (including co-products and their upstream chains) as the most scientific solution over the allocation approach (dividing environmental impacts based on an allocation factor), the latter is still most common. In this study, system expansion, mass, economic, and energy-based allocation are studied within a biosystem engineering case study, which provides two marketable outputs, biogas and nano-cellulose. The global warming potential (GWP) is used as basis for comparison. There is hardly any difference between system expansion and economic allocation, but it is also shown how problematic the latter approach is for newly introduced products because the market price is still very high and not representative. Results show that the GWP with mass allocation has the lowest impact; however, this approach is inappropriate since the outputs are a solid product and biogas, which are hard to compare based on a mass basis. Overall, based on the studied approach, results can be significantly different. Hence, it is recommended to avoid comparison and interpretation of results when using different modeling approaches.
Localization accuracy of a robot platform using indoor positioning methods in a realistic outdoor setting
Authors: Supper Georg , Barta Norbert , Gronauer Andreas , Motsch Viktoria
Published: June 2022

Precise localization and reliable navigation are of crucial importance in order to fully automatize tasks in agriculture using field robots in an outdoor environment. However, under certain conditions, absolute localization accuracy of outdoor positioning systems, mainly global navigation satellite systems (GNSS), might drop under a critical threshold. Thus, field robots must rely on indoor positioning methods such as laser scanners and adaptive Monte Carlo localization (AMCL) in order to maintain necessary localization accuracy. Here, the localization accuracy of the field robot “Mathilda” using such an indoor positioning method is evaluated in a realistic scenario, in this case, an outdoor laboratory with plant pots aligned in rows. For this, the positioning error of the robot was determined using a motion capture system. The results showed a mean absolute distance error over all positions of 198.9 mm and a mean angular error over all positions of 4.9°. Most likely, limitations by the differential drive system, the large pneumatic tires, and unsatisfactory path planning are responsible for this large deviation.
Testing the iMTA Productivity Costs Questionnaire (iPCQ) for the use with chronic disease patients in Switzerland / Prüfung des iMTA Productivity Costs Questionnaire (iPCQ) für den Einsatz bei Patienten/-innen mit chronischen Krankheiten in der Schweiz
Authors: Friedli Thomas , Gantschnig Brigitte
Published: June 2022

Background

Complex interprofessional programs in health care are dependent on the valid measurement of outcomes. The iMTA Productivity Costs Questionnaire (iPCQ) is one of the few instruments measuring productivity in a comprehensive way which is available in German language. This study explores the validity of the German-language iPCQ with a focus on test content and response processes. The aim of this study is to validate the German version of the iPCQ for the use with people with chronic conditions in Switzerland and to make suggestions for adaptation to the developers.

Method

This study is a qualitative validation study. We conducted cognitive interviews with people with chronic illnesses and with other experts and analysed them based on the framework method.

Results

Participants had problems understanding many items and explanations and remembering correct answers. Furthermore, the study revealed construct-related problems in measuring the productivity of people with partial incapacity for work.

Conclusions

The results show that German version of the questionnaire needs improvement in order to guarantee validity and reliability.
Potential of Using WVO for a Restaurant EV Charging Station
Authors: Albatayneh Aiman
Published: June 2022

This research comprised an evaluation study for a charging station based on waste vegetable oil or biodiesel fuel. The biodiesel was produced from waste vegetable oil (WVO) and will be used (or the WVO) to charge electric cars for restaurant’s customers in their car park. The main concept behind the charging station is to be part of a restaurant that serves its customers and then uses its WVO or biodiesel to fuel a diesel engine that generates electricity to charge their electric vehicles (EV). The economic and environmental impacts of the direct use of WVO-EV charging station are promising because the costs associated with purchasing WVO are lower than those of purchasing crude oil or gas. There are several options and scenarios when selecting the perfect sized generator; using charging up to a maximum rated power of 6.6 kW is more feasible despite its higher initial cost as the simple payback period will be less than 3 years and the internal rate of return of the project is 44 %. The total saving at the end of the project for a generator with maximum rated power of 10 kW (option B) is $ 58 000. Conversely, for a generator with maximum rated power of 6.6 kW (option A) the project will cover its initial cost in around 4 years and the internal rate of return is 26 %. The total saving at the end of the project is $ 52 000. Furthermore, lower amount of greenhouse gases is produced from the burning of WVO directly. The final results showed that WVO is more feasible as it is available for free and could be burnt directly in the diesel engine. In economic terms, the project is feasible for both WVO and biodiesel as it has a high net present value and short payback period. A WVO-EV charging station can also improve the national economy by preparing it for the electric car era and, if applied to a large number of restaurants, will save a significant amount of electricity and reduce the expected strain on the electricity grid caused by the increasing number of electric cars.
Faz sentido que uma empresa transfira a sua sede ou estabelecimento por causa do Regulamento Geral sobre a Proteção de Dados?
Authors: Cunha Pinto Benedita
Published: June 2022

The article aims to make an analysis of the issue of the transfer of headquarters or even of the establishment because of the General Data Protection Regulation (Regulation (EU) 2016/679 of 27 April 2016). In a first phase we approach in detail the territorial scope of the GDPR in accordance with the establishment criterion and the targeting criterion. Then, we point out some limitations related to the execution of the aforementioned Regulation, as well as some reasons that may lead a company to consider transferring its registered office to a country outside the European Economic Area (EEA) or, simply, opting to resort to establishment migration. In this context, we use to address two mechanisms for implementing the GDPR – Designation of a Representative in the EEE and Standard Contractual Clauses – as they reveal matters of great practical interest to companies. Finally, we will make some proposals towards a possible prevention of establishment migration.
The Effect Of Environmental Performance On Profitability With Environmental Disclosure As Moderating
Authors: Ramlawati Ramlawati  , Asriani Junaid  , Syarifah Nurhalisa Alattas  , Muslim Muslim
Published: June 2022

Profitability describes a company's capacity to generate profits. Profitability is typically increased by implementing a nonexistent budget system, reducing marketing expenses, and implementing other asset management strategies. However, asset management is not the only factor affecting profitability in this instance. Environment, society, and economy have a fundamentally interdependent relationship. The company's existence in the environment has direct or indirect effects on the environment and social reality. Additionally, the company has great potential to alter the community's environment; therefore, the company's profitability improvement strategy must incorporate environmental considerations. This study focuses on 15 companies listed on the Indonesia Stock Exchange in 2018-2020 that received environmental performance ratings from PROPER. Quantitative research utilizing secondary data is conducted in the present study. Purposive sampling was used to carry out the sampling technique. Multiple moderation linear regression analysis, classical assumption testing, and hypothesis testing were employed in the investigation. The results indicated that environmental performance had a positive and statistically significant effect on profitability, with a significance level of 0.000. With a significant value of 0.000, the environmental disclosure variable strengthened the relationship between environmental performance and profitability.
Real Earnings Management And Firm Value: Examination Of Costs Of Real Earnings Management
Authors: Alex Johanes Simamora  , Atika  , Masculine Muhammad Muqorobin
Published: June 2022

The objective of this research is to find the evidence of (1) REM towards firm value and (2) the moderating role of costs of REM which are market share, financial health, and effective tax rate between REM and firm value. Research samples are manufacturing firms listed on the Indonesian Stock Exchange 2018-2020. REM includes abnormal CFO, abnormal production, and abnormal discretionary expenses. Data analysis uses a white regression test. Based on data analysis, REM has a negative effect on firm value which indicates that REM reduces economic value. Market share and financial health weaken the negative effect of REM on firm value, indicating that REM is a signal where the firm has strong industry and financial advantages to increase firm value. The effective tax rate has no moderating effect between REM and firm value, indicating that low effective tax rate can be both efficient tax planning such as tax avoidance and aggressive tax planning such as tax evasion. Research contribution gives academics, financial statement users, and regulatory bodies an additional literature of REM as a signaling tool of industry and financial health advantages.
Determinant Of Corporate Social Responsibility And Its Implication Of Financial Performance
Authors: Hamdani  , Dhea Zatira  , Eni Suharti
Published: June 2022

This study aims to see whether green accounting, environmental performance and company size can affect company performance moderated by CSR for the 2016-2020 period. This study uses a panel data regression method with a sample of companies listed in PRPOPER. The results show that partially green accounting and environmental performance variables can affect companies in implementing CSR while the size variable can not have an effect, as well as in the next results only environmental performance variables that can affect financial performance while green accounting, size and CSR have no effect on financial performance. An interesting finding is that green accounting which is a cost that must be incurred for CSR activities does not affect financial performance where this indicates that companies that implement CSR consider that environmental costs have been treated as operating costs in general.
PEMBUATAN HAND SANITIZER OTOMATIS DI FASILITAS UMUM UNTUK MENGURANGI PENYEBARAN COVID-19 DI RT 21 RW 02 KELURAHAN SIDOMULYO KOTA BENGKULU
Authors: Haidi Junas , Santosa Hendy , Kurniawan Adhadi
Published: June 2022

Bengkulu merupakan salah satu provinsi yang terkena dampak corona virus (Covid-19). Salah satu cara untuk mencegah penularan Covid-19 dengan membersihkan tangan dengan handsanitizer. Oleh karena itu, pada PPM ini dilakukan pembuatan hand sanitaizer otomatis difasilitas umum RT21 RW 02 Kelurahan Sidomulyo Kota Bengkulu. Adapun proses yang dilakukan pada pengabdian ini sebagai berikut: Desaian peralatan elektronik, desain box panel, perakitan daan fabrikasi hand sanitaizer 10 Unit di Laboratorium Elketronika, Sosialisasi kepada masyarakat dan pemasangan hand sanitizer otomatis difasilitas umum. Adapun peserta yang terlibat dalam kegiatan pengabdian masyarakat adalah Dosen, asisten laboratorium elektronika dan masyarakat RT 21. Hand sanitizer otomatis yang dibuat bekerja sangat baik dikarenakan cukup mendekatkan tangan ke sensor jarak dan tanpa ada sentuhan kebenda maka cairan hand sanitizer akan keluar menyemprot ketangan. Sehingga peralatan ini sangat efektif untuk pencegahan covid-19. Adapun fasilitas umum yang dipasang hand sanitizer sebagai berikut: Pos Ronda RT 21, Masjid Alhidayah, Masjid At- Taqwa dan warung dilingkungan RT 21.Â  Pada saat sosialisasi dan pemasangan hand sanitizer otomatis, masyarakt dilingkungan RT 21 sangat antusias yang diikuti oleh 25 peserta mulai dari ketua RT, Pengurus Masjid dan masyarakat. Dengan banyaknya tokoh masyarakat yang ikut pada pengabdian masyarakat ini dapat membuat masyarakat lebih peduli terhadap pencegahan virus corona.
Kegiatan Pelatihan untuk Meningkatkan Kesiapan Petugas Puskesmas Cibeureum dan Salawu di Tasikmalaya Terhadap Penerapan Teknologi UVC dan Teknologi Ozone sebagai Alat Sterilisasi
Authors: Busaeri Nundang , Hiron Nurul , Permana Prama , Faturahman Yuldan , Khoerunisa Nisa
Published: June 2022

Artikel ini membahas tentangÂ  kegiatan pelatihan untuk peningkatan pengetahuan, penggunaan dan kewaspadaan dalam menggunakan teknologi UVC dan Ozon sebagai alat atau media sterilisasi. Pelatihan ditujukan kepada petugas kesehatan di Puskesmas Cibeureum Kota Tasikmalaya dan Puskesmas Salawu di Kabupaten Tasikmalaya. Metode yang digunakan adalah Analisis situasi mitra, Pre-test, edukasi peserta melalui webinar, Post-test dan kesimpulan. Hasil dari pelaksanaan ini adalah penggunaan teknologi UVC dan ozon sebagai media sterilisasi memerlukan pelatihan agar masyarakat yang bekerja dibidang pelayanan kesehatan tidak mendapatkan dampak negatif dari teknologi tersebut. Dengan kuesioner yang terdiri dari tiga dimensi, yaitu pengetahuan umum, utilitas dan kewaspadaan dapat diketahui tingkat pengetahuan peserta dalam kesiapan penerapan teknologi tersebut di lapangan. Meskipun peserta mayoritas adalah pekerja pada pelayanan kesehatan, ternyata teknologi UVC dan Ozon merupakan teknologi yang belum begitu populer pada kalangan petugas kesehatan. Hal ini memberikan makna pentingnya pengenalan dan pelatihan teknologi baru yang dapat digunakan sebagai alat sterilisasi dan desinfektan dari bakteri dan virus, khususnya virus Covid-19
Sosialisasi Teknologi Pembuatan Pakan Ikan Lele Sebagai Solusi Di Masa Pandemi Covid-19 Pada Peternakan Lele “Tirta Agung” Gudo Jombang
Authors: Sukamto Sukamto , Sudiyono Sudiyono , Sumarji  , Patria Domas Galih Patria
Published: June 2022

Usaha peternakan lele "Tirta Agung” Jombang berpotensi untuk dikembangkan, karena kondisi wilayah, ketersedian bahan pakan lokal dan tenaga kerja cukup melimpah. Permasalahan utama yang dihadapi adalah penggunaan pakan komersial yang relative mahal sehingga setiap kali panen  mengalami kerugian. Oleh karena itu dalam pelaksanaan pengabdian pada masyarakat difokuskan pada sosialisasi, pendampingan dan implementasi produksi pakan ikan lele yang berkualitas dari bahan baku lokal yang murah. Diharapkan implementasi teknologi tersebut dapat meningkatan produktifitas. Metode pelaksanaan terdiri dari : (1). Penyamaan presepsi dengan pemilik dan tenaga kerja. (2). Inventarisasi bahan baku pakan local yang murah dan tersedia secara bekelanjutan. (3). Pelatihanan dan pendampingan teknik penyusunan formula pakan, pelleting dan implementasi, dan (5). Evaluasi pelaksanaan kegiatan.  Secara keseluruhan tingkat keberhasilan dari kegiatan adalah pakan telah berhasil diformula dan dibentuk pellet, sehingga dapat mereduksi harga pakan sampai 61%, dan pakan disukai oleh ikan lele. Kedepan mitra bersedia untuk mengimplementasikan hasil sosialisasi teknologi pada periode budidaya lele berikutnya. Diharapkan  implementasi  teknologi pada unit usaha ternak lele dapat menghasilkan keuntungan yang signifikan dan berkelanjutan.