bluuebunny/crossref_metadata_2025 huggingface dataset:
Comprehensive genomic profiling of parathyroid carcinoma.
Authors: Kang Hyunseok , Schubert Adrian Daniel , Ladenson Paul , Ball Douglas Wilmot , Chung Jon , Schrock Alexa Betzig , Ross Jeffrey S. , Miller Vincent A. , Stephens Philip J. , Ali Siraj Mahamed
Published: July 2017

6088

Background: Parathyroid carcinoma (PC) is a rare endocrine malignancy, which can cause life-threatening hypercalcemia. Initial surgery is often noncurative, and adjunctive radiotherapy and previous chemotherapies have not been shown to be effective. Previous studies identified recurring mutations in CDC73 and PRUNE2in a limited number of patients. We queried whether comprehensive genomic profiling (CGP) would have potential to discover novel targets of therapy. Methods: DNA was extracted from 40 microns of FFPE sections from 13 consecutive cases of relapsed/metastatic PC. CGP was performed on hybridization-captured, adaptor ligation based libraries to a mean coverage depth of 672x for up to 315 cancer-related genes plus 37 introns from 14 genes frequently rearranged in cancer. Genomic alterations (GA) included base substitutions (SUB), INDELs, copy number alterations (CNA) and fusions/rearrangements. Clinically relevant GA (CRGA) were defined as GA linked to drugs on the market or under evaluation in mechanism driven clinical trials. Results: Total of 13 specimens were identified from 7 male and 6 female patients. The mean age of the patients in this study was 54 years (range 38 to 76 years). All (100%) cases were Stage IV at the time of CGP. Tumor mutation burden was generally low - median mutation load per mega base was 1.8. There were 58 total GA (4.5 GA/sample) and 10 CRGA (0.8 CRGA/sample). The most frequent GA were non-CRGA mutations in TP53 (31%) and CDC73 (31%). MEN1 mutations were identified in 23% of cases. Frequent alterations in genes controlling cell cycle progression at G1 including CDKN1B, CDKN2A, CDKN2B and CDKN2C were identified (30%). The most frequent CRGA involved PTEN (23%), NF1 (23%) and KDR (15%). No alterations in BRAF or RETwere identified. A patient with KDR mutation treated with cabozantinib experienced > 50% drop in PTH level and radiographic partial response in 3 months. Conclusions: CGP identified previously unreported TP53 mutations in PCs and potentially actionable genomic alterations including PTEN, NF1 and KDR. Clinical benefit and response observed in a patient treated with VEGFR targeted therapy suggest that patients with this rare tumor may be candidates for targeted therapies.
Accelerating clinical trial enrollment with comprehensive genomic profiling (CGP) and just-in-time clinical trial sites: An index case of a paradigm shift.
Authors: Singal Gaurav , Madduri Deepu , Yuan Lara , Luo David , Upadhyay Aparna , Wiener Matthew B. , Wander Seth Andrew , Lynam Eric B. , Bourque David , Parker Alex , Manor Rob , McCarthy Will , Maneval Edna Chow , Ali Siraj Mahamed , Miller Vincent A.
Published: July 2017

6539

Background: In many instances, trials may offer the best or only therapeutic option for patients with rare findings. However, conducting clinical trials of novel therapeutics targeting rare molecular variants is challenging. Patient populations are small, distributed, and predominantly in community settings where trial access remains limited by awareness and site availability. These challenges increase costs of drug development and approval, delaying widespread patient access. Methods: Foundation Medicine deployed a trial education and access program, “Precision Enrollment,” with Ignyta (a trial sponsor) and Pharmatech (a site management organization, or SMO, enabling “Just-In-Time” clinical trials) (Wiener, JCO 2007). Infrastructure and algorithms developed at Foundation Medicine (“SmartTrials Engine”) matched sequenced patients (avg n = 800/wk) with activating NTRK, ROS1, or ALK fusions to the phase II study of Entrectinib (NCT02568267). Oncologists at Foundation Medicine, through peer-to-peer outreach, facilitated trial access by providing trial and nearest site information to treating providers of matched patients. Results: 107 treatment-eligible patients with NTRK, ROS1, or ALK fusions were matched by the SmartTrials Engine; 36 (33%) expressed interest in trial participation. One such patient with NSCLC and a CD74-ROS1 fusion was unable to participate at an open trial site due to inability to travel. The patient’s site was part of the “Just-In-Time” network, with IRB and contract pre-approval, and was activated in only 3 days. Total time from patient identification to initiation of therapy was 7 days. Conclusions: We demonstrate a novel methodology for patient matching to trials targeting rare genomic findings, including in community settings. If extended, such innovative partnerships combined with computational matching infrastructure, could improve drug development and therapeutic access.
Loss of heterozygosity in multiple myeloma: A role for PARP inhibition?
Authors: Pawlyn Charlotte , Loehr Andrea , Tytarenko Ruslana , Deshpande Shayu , Sun James , Fedorchak Kyle , Mughal Tariq I. , Davies Faith , Walker Brian , Raponi Mitch , Morgan Gareth John
Published: July 2017

8026

Background: PARP inhibitors can induce synthetic lethality in tumors characterized by homologous recombination deficiency (HRD). Two PARP inhibitors are approved for the treatment of BRCA mutated ovarian cancer. HRD can be detected by evaluating genome-wide loss of heterozygosity (LOH), which is associated with response to PARP inhibition. Myeloma (MM) is a genetically unstable tumor and we hypothesized that LOH could be detected in patient samples, supporting a potential role for PARP inhibition in MM. Methods: We analyzed 406 cases at all disease stages: MGUS (n = 7), smoldering MM (SMM, n = 30) newly diagnosed MM (NDMM, n = 71), treated MM (TRMM, n = 64) and relapsed MM (RLMM, n = 234). CD138+ plasma cell DNA underwent targeted next generation sequencing (FoundationOne Heme) interrogating 405 cancer related genes and 3543 single nucleotide polymorphisms (SNPs) across the genome. An algorithm using the minor allele frequencies of the examined SNPs and copy number profile across the 22 autosomal chromosomes identified LOH segments. Events unlikely to be caused by HRD, e.g. whole chromosome or chromosome-arm loss, were excluded. The percentage of genomic LOH for each sample was calculated as the sum of the lengths of included LOH segments divided by the length of the interrogated genome. Results: We found evidence of HRD detected by LOH with higher LOH selecting for patients with poor outcome. LOH increases with advancing disease stage from a median of 0.3% in MGUS to 3.1% in RLMM. LOH was highest in the PR and MMSET molecular subgroups and correlated significantly with the gene expression defined risk score GEP70 (R = 0.4, p < 0.001) and proliferation index (R = 0.4, p < 0.001). Outcome of RLMM patients, the biggest clinical group, was analyzed and patients with LOH above the 3rdquartile (≥5%LOH) had significantly worse overall survival than those with lower levels (p < 0.001). LOH correlates and overlaps with other metrics of poor prognosis, suggesting it may be a prognostic marker itself. Conclusions: We demonstrated LOH in MM samples, increasing as disease progresses and associated with poor prognosis. These data support the further evaluation of PARP inhibitors in MM patients, particularly in the relapsed setting with a high unmet need for new treatments.
Association of ALK resistance mutations by EML4-ALK variant (v3 vs. non-v3) in ALK+ non-small cell lung cancer (NSCLC).
Authors: Ou Sai-Hong Ignatius , Schrock Alexa Betzig , Gowen Kyle , Stephens Philip J. , Ross Jeffrey S. , Johnson Melissa Lynne , Lovly Christine Marie , Ali Siraj Mahamed , Miller Vincent A. , Shaw Alice Tsang
Published: July 2017

9010

Background: ALK rearrangements are established targetable drivers in NSCLC. Recent reports indicate differential progression-free survival to ALK inhibitors according to specific EML4-ALK variant. Methods: We analyzed samples from 634 unique NSCLC patients (704 samples) with tumors harboring ALK rearrangements ( ALK+) detected using hybrid-capture based genomic profiling performed on DNA isolated from FFPE tissue specimens (676 samples) or ctDNA isolated from blood (28 samples) during the course of clinical care. Results: Of the 634 ALK+ cases, we identified 200 (32%) EML4- ALKv1 (E13; A20), 50 (8%) EML4-ALKv2 (E20; A20), 204 (32%) EML4- ALKv3 (E6; A20), 78 (12%) other EML4-ALK, and 102 (16%) non- EML4 ALK rearrangements. Despite relatively equal frequency of EML4-ALK v1 and v3 in this dataset, the presence of a known ALK resistance mutation (n = 40 cases) was significantly associated with v3 as compared to v1 (P < 0.0002). G1202R mutation in particular was significantly associated with EML4-ALK v3 versus v1 (P < 0.002), and as compared to all non-v3 (P = 0.02). The tumor mutation burden (TMB) was generally low (median v1: 1.8, v3: 2.5, non-v3: 1.8 mutations/Mb), and although significantly different between v1 and v3 (P = 0.0008) and v3 and non-v3 (P = 0.003), the difference is not expected to be clinically relevant. Available ALK+ cases with paired pre- and post-treatment samples tested for a single patient will also be evaluated by ALKfusion variant, as well as for novel non-ALK mechanisms of acquired resistance, including a case with MET kinase domain duplication acquired post-ALK targeted therapy. Conclusions: The use of tissue and blood-based next generation sequencing allows for detection of the specific ALK fusion partner, increases the understanding of the biology of ALK+ NSCLC, and may have value to foretell potential mechanisms of resistance and inform the selection of ALK inhibitor therapy. [Table: see text]
Characteristics of advanced non-small cell lung cancer (aNSCLC) patients (pts) receiving molecular diagnostic (MD) testing in U.S. routine clinical practice.
Authors: Wang Lisa I , Shewade Ashwini , Lambert Peter , Arnieri Brandon , Capra William , Khorshid Mohsen , Mughal Tariq I , Gay Laurie M. , Page Damian R. , Foser Stefan
Published: July 2017

e20627

Background: Hybrid capture (HC)-based next generation sequencing (NGS) combined with extensive molecular interpretation, such as Foundation Medicine (FMI) testing, is increasingly important for a comprehensive molecular diagnosis in the routine clinical management of lung cancer (LC) pts. FMI and other NGS platforms (including HC alone) support optimal treatment (trt) decisions by assessing multiple genetic alterations that drive LC progression. Our aim was to characterize aNSCLC pts receiving FMI or other types of MD tests using a real world oncology electronic health record (EHR) database. Methods: Flatiron aggregates pt-level EHR from a large network of cancer clinics in the US. Inclusion criteria were aNSCLC diagnosis and ≥2 clinic visits within the Flatiron network on or after January 1, 2011. Presence of MD testing was based on 5 LC biomarkers ( EGFR, ALK, KRAS, ROS1, PD-L1). Demographic and tumor characteristics at the time of aNSCLC diagnosis and trts received were summarized across 3 mutually exclusive testing groups (grps): FMI, other NGS and non-NGS. Results: As of Sept 30, 2016, the aNSCLC cohort included 30,489 pts across 4 groups: FMI (1,019 pts); other NGS (1,327 pts); non-NGS (15,205); no tests (12,938). As expected, the number of pts with FMI or NGS testing has increased in recent years. Pts in the FMI grp tended to be younger (66 vs. 68-69 years), non-smokers (25% vs. 17-19%) and have squamous cell histology (13% vs. 8-10%) compared to other MD test grps. 30% of FMI pts received testing prior to initiating first trt, compared with 38% of other NGS and 53% of non-NGS pts. For 565 pts (of 1,019) with available data on first trt after FMI testing, 24% (136 pts) initiated a NCCN recommended targeted trt for LC. In the FMI grp, 528 pts (52%) received at least one other MD test: EGFR (89%), ALK (83%), ROS1 (39%), KRAS (31%), PD-L1 (18%) and test types were 67% FISH, 55% PCR, 17% other NGS and 15% IHC. Conclusions: Differences in age, smoking and histology exist between pts receiving FMI vs. other MD tests. This analysis of a large real world pt cohort tested with FMI further supports the value of broad genomic profiling to identify rare driver mutations and ensure optimal trt.
Diphenyleneiodonium Mitigates Bupivacaine-Induced Sciatic Nerve Damage in a Diabetic Neuropathy Rat Model by Attenuating Oxidative Stress
Authors: Ji Zhong-Hua , Liu Zhong-Jie , Liu Zi-Ting , Zhao Wei , Williams Brian A. , Zhang Hong-Fei , Li Le , Xu Shi-Yuan
Published: July 2017

BACKGROUND:

Increased oxidative stress has been linked to local anesthetic-induced nerve injury in a diabetic neuropathy (DN) rat model. The current study explores the effects of diphenyleneiodonium (DPI) chloride, an NADPH oxidase (NOX) inhibitor, on bupivacaine-induced sciatic nerve injury in DN rats.

METHODS:

A rat DN model was established through high-fat diet feeding and streptozotocin injection. The model was confirmed via testing (i) blood glucose, (ii) hindpaw allodynia responses to von Frey (VF) monofilaments, (iii) paw withdrawal thermal latency (PWTL), and (iv) nerve conduction velocity (NCV). Bupivacaine (Bup, 0.2 mL, 5 mg/mL) was used to block the right sciatic nerve. DPI (1 mg/kg) was injected subcutaneously 24 hours and 30 minutes before the sciatic block. At 24 hours after the block, NCV, various reactive oxygen species, and Caspase-3 were evaluated to determine the extent of sciatic nerve injury.

RESULTS:

The DN rat model was successfully established. Compared with the DN control group, the postblock values of VF responses (DN-Con, 16.5 ± 1.3 g; DN + Bup, 19.1 ± 1.5 g, P < .001) and PWTL significantly increased (DN-Con, 13.3 ± 1.1 seconds; DN + Bup, 14.6 ± 1.1 seconds, P = .028); the NCV of sciatic nerve was significantly reduced (DN-Con, 38.8 ± 2.4 m/s, DN + Bup, 30.5 ± 2.0 m/s, P = .003), and sciatic nerve injury (as indicated by axonal area) was more severe in the bupivacaine-treated DN group (DN-Con, 11.6 ± 0.3 μm2, DN + Bup, 7.5 ± 0.3 μm2, P < .001). In addition, DPI treatment significantly improved nerve function (VF responses, 17.3 ± 1.3 g; PWTL, 13.4 ± 1.1 seconds; NCV, 35.6 ± 3.1 m/s) and mitigated loss of axonal area (9.6 ± 0.3 μm2). Compared to the DN + Bup group (without DPI), the levels of lipid peroxides and hydroperoxides, as well as the protein expression of NOX2, NOX4, and Caspase-3, were significantly reduced in the DN + Bup + DPI group (P < .05).

CONCLUSIONS:

Subcutaneous injection of DPI appears to protect against the functional and neurohistological damage of bupivacaine-blocked sciatic nerves in a high-fat diet/streptozotocin–induced DN model.
Gender in modern Greek historiography
Authors: Papadogiannis Nikolaos
Published: July 2017

This article analyses the emergence and development of the study of gender in modern Greek historiography in the broader sense, exploring works that incorporate, even to a minor extent, the gender factor. It shows that despite the manifold barriers that gender historians have faced, there has been a slow but steady process of diffusion of gender in modern Greek historiography in general. The article also shows that historical research on gender relations in Greece initially focused on the study of women, historicising, however, their relations with men. Thus, in line with what Kantsa and Papataxiarchis argue about the relevant scholarship at the international level, no linear transition from the study of women to the examination of gender relations occurred. What has transpired in the last two decades, however, is that the relevant historiography has gradually broadened to encompass a more systematic analysis of the (re)making of masculinities. It has also been enriched by the study of the intersection of gender and age as well as of transnational flows and their impact on gender, tendencies that have been slightly neglected in other reviews of the study of gender in Greek historiography.
Review of Yannis Skalidakis', Η ελεύθερη Ελλάδα: Η εξουσία του ΕΑΜ στα χρόνια της κατοχής (1943-1944) [Free Greece: The power of EAM in the occupation years, 1943–44]
Authors: Haralabidis Menelaos
Published: July 2017

Yannis Skalidakis. Η ελεύθερη Ελλάδα: Η εξουσία του ΕΑΜ στο χρόνια της κατοχής (1943-1944) [Free Greece: The power of EAM in the occupation years, 1943–44]. Athens: Asini, 2014. 416 pp.
Review of Kevin Featherstone et al., Οι τελευταίοι Οθωμανοί: Η μουσουλμανική μειονότητα της Δυτικής Θράκης 1940-1949 [The Last Ottomans: The Muslim Minority of Greece, 1940–1949]
Authors: Karakatsanis Leonidas
Published: July 2017

Kevin Featherstone, Dimitris Papadimitriou, Argyris Mamarelis and Georgios Niarchos. Οι τελευταίοι Οθωμανοί: Η μουσουλμανική μειονότητα της Δυτικής Θράκης 1940-1949 [The Last Ottomans: The Muslim Minority of Greece, 1940–1949 (New York: Palgrave Macmillan, 2011)]. Athens: Alexandreia, 2013. 574 pp.
Inadequate pelvic radiographs: implications of not getting it right the first time
Authors: Parker S , Nagra NS , Kulkarni K , Pegrum J , Barry S , Hughes R , Ghani Y
Published: July 2017

Introduction

Pelvic radiography is a frequent investigation. European guidelines aim to ensure appropriate use and adequate quality. When initial images are inadequate, repeat radiographs are often required, which may have significant patient safety and economic implications.

Objectives

The study aimed to assess the adequacy of pelvic imaging across three orthopaedic centres, to identify causes for inadequate imaging and to establish the cost of inadequate imaging from financial and patient safety perspectives.

Methods

Pelvic radiographs were identified on Picture Archiving and Communication System software at three UK hospitals. Radiographs were assessed against European guidelines and indications for repeat imaging were analysed.

Results

A total of 1,531 sequential pelvic radiographs were reviewed. The mean age of patients was 60 years (range 5 months to 101 years). Of this total, 51.9% of images were suboptimal, with no significant difference across the three hospitals (P > 0.05). Hospital 3 repeated radiographs in 6.3% of cases, compare with 18.1% and 19.7% at hospitals 1 and 2, respectively (P > 0.05). Hospital 3 identified pathology missed on the initial radiograph in 1% of cases, compared with 5.4% and 5.5% at hospitals 1 and 2, respectively (P > 0.05). Out-of-hours imaging is associated with a higher rate of suboptimal quality (69.1%) compared with normal working hours (51.3%; P = 0.006). Adequacy rates vary with age (χ 2 = 43.62, P < 0.001). Risk of having a suboptimal radiograph increases above the age of 60-years (χ 2 = 4.45, P < 0.05). The annual cost of repeat radiographs was £56,200 per hospital.

Discussion and conclusion

High rates of pelvic radiograph inadequacy can lead to missed pathology and the requirement for repeat imaging, which has significant patient safety and financial implications. Risk factors for inadequate radiographs include older patients and those having out-of-hours imaging.
GÊNERO E DOCÊNCIA: UM OLHAR SOB A PERSPECTIVA DOS DISCENTES DO CURSO DE PEDAGOGIA
Authors: De Jesus Adriana Regina , Costa Rogerio Da
Published: July 2017

O presente artigo tem como objetivo identificar por meio das falas dos discentes do Curso de Pedagogia da Universidade Estadual de Londrina as percepções que se têm em relação ao gênero e à docência. Para o desenvolvimento deste estudo, utilizou-se como metodologia de pesquisa a abordagem qualitativa. Na busca de recuperar tais percepções dos discentes, a pesquisa bibliográfica, a análise documental e a pesquisa de campo formaram o conjunto de procedimentos investigativos. Ao término da pesquisa, constatou-se que os alunos relacionam à docência com aspectos de infantilização e feminização. Outro ponto importante a ressaltar é que o currículo do curso de Pedagogia da Universidade Estadual de Londrina necessita de um novo olhar em relação ao gênero e à docência, podendo assim contribuir para a formação da leitura crítica de mundo e da condição humana dos estudantes do referido curso.
CONSELHOS MUNICIPAIS DE EDUCAÇÃO: MONITORAMENTO E AVALIAÇÃO DE PLANOS MUNICIPAIS DE EDUCAÇÃO RELATIVOS AO PNE 2014-2024
Authors: Souza Donaldo Bello de , Alcântara Alzira Batalha
Published: July 2017

Em consonância às disposições do Plano Nacional de Educação (PNE) 2014-2024 – Lei nº 13.005, de 25 de junho de 2014 –, os planos infranacionais deverão estabelecer os seus próprios sistemas de monitoramento e avaliação, observando coesão em relação a este plano nacional. Assim, este artigo, com base em análise documental, investiga o papel atribuído aos Conselhos Municipais de Educação (CME) no monitoramento e na avaliação dos Planos Municipais de Educação (PME), tomando por base empírica 19 planos pertencentes à Região Metropolitana do Rio de Janeiro, alinhados ao novo PNE. Como conclusão mais geral, verificou-se que a maioria das respectivas leis que regulamentam os planos analisados inclui, de forma explícita, o CME, ao lado da Secretaria Municipal de Educação, como órgão privilegiado no monitoramento contínuo e avaliações dos planos. Todavia, a proeminência dada ao CME no corpo das leis para estas ações apresenta certo descompasso em relação às decisões do plano propriamente dito (metas e estratégias), uma vez que, neste, sua presença é exígua, pois somente dois PMEs ressaltam o papel desse órgão colegiado em seções específicas, enquanto que outros dois o mencionam em duas estratégias. Ressalta-se, ainda, que caso o corpo da lei venha a se impor, é possível que um processo de monitoramento e avaliação sistemática desses planos municipais possa tornar-se efetivo, viabilizando o replanejamento das ações e adequação das estratégias, concorrendo, portanto, para a consecução local do plano.
ESTRATÉGIAS DE ENSINO-APRENDIZAGEM UTILIZADAS NOS CURSOS DE HISTÓRIA, FILOSOFIA E PEDAGOGIA: CONCEPÇÕES DE ALUNOS E PROFESSORES
Authors: Toledo-Pinto Eliane Aparecida , Cortinove Letícia Carolina , Carvalho Dariel De
Published: July 2017

A compreensão e a utilização de estratégias de ensino-aprendizagem são essenciais ao processo educacional. Para cada disciplina e turma há contextos diferentes que requerem estratégias de ensino que contribuam para que o estudante compreenda o conteúdo. Assim, esta pesquisa surgiu da necessidade de investigar e analisar as diversas estratégias de ensino-aprendizagem utilizadas nos cursos de licenciatura de História, Filosofia e Pedagogia de uma universidade privada no município de Bauru/SP, bem como a visão dos seus docentes e discentes. Através dos questionários semiestruturados aplicados aos docentes e aos discentes foi possível evidenciar a importância dessas estratégias no processo de ensino-aprendizagem, como também as relações interpessoais estabelecidas. Os docentes utilizaram diversas estratégias de ensino e aprendizagem ao ministrarem suas aulas e os alunos as aprovaram. Domínio de conteúdo, interação entre professor e aluno, explicação clara e objetiva, relação entre teoria e prática, uso de recursos didáticos e tecnológicos, são apenas algumas das estratégias citadas por alunos e professores que facilitam o processo de ensino e aprendizagem. Os resultados evidenciaram que as estratégias são importantes para a compreensão do conteúdo ensinado, bem como a didática e os recursos utilizados pelos docentes, o que contribui significativamente para uma educação de qualidade.
Independencias, ciudadanía y exclusión racial en Argentina. Visiones de los siglos XIX, XX Y XXI
Authors: Villavicencio Susana , Schiffino María Beatriz , Rodríguez Gina Paola
Published: July 2017

El artículo indaga sobre el uso de la raza, como concepto y como tecnología de poder, en el discurso de formación de la ciudadanía en Argentina entre los siglos XIX y XXI . Primeramente, aborda la construcción ficcional del pueblo de la República emprendida por las elites decimonónicas y por la cultura científica de inicios del siglo XX , en cuya base se halla el mito de la Argentina blanca y la consecuente exclusión de las poblaciones indígenas y afrodescendientes del todo nacional. En segundo lugar, analiza los dispositivos estatales destinados a controlar estas poblaciones. Por último, contempla el proceso de re-etnización de la población argentina durante el transcurso del siglo XX.
Notas bibliográficas: la conversión de los fieles. La desvinculación electoral de las clases medias de la Unión Cívica Radical de Gabriel Obradovich
Authors: Gené Mariana
Published: July 2017

Notas bibliográficas: la conversión de los fieles. La desvinculación electoral de las clases medias de la Unión Cívica Radical de Gabriel ObradovichBuenos Aires, Teseo, 2016 , 300 págs.
Notas bibliográficas: comunicación gubernamental en acción. Narrativas presidenciales y mitos de gobierno de Mario Riorda y Omar Rincón
Authors: Del Prado Abelardo
Published: July 2017

Notas bibligoráficas: comunicación gubernamental en acción. Narrativas presidenciales y mitos de gobierno, de Mario Riorda y Omar Rincón,Buenos Aires, Biblos, 284 págs.
The Effect of Dietary and Exercise Self-Management Support Program on Dietary Behavior Exercise Behavior and Clinical Outcomes in Muslim Patients with Poorly Controlled Type 2 DM in a Community Setting in Indonesia
Authors: Pamungkas Rian Adi , Chinnawong Tippamas , Kritpracha Charuwan
Published: July 2017

Purpose: The objective of this study was to examine the effect of dietary and exercise self-management support program on the dietary behavior, exercise behavior, and clinical outcomes of Muslim patients with poorly controlled type 2 DM in Indonesia. Methods: This study was a quasi-experimental, two group, pre-test and post-test design. The experimental group received the dietary and exercise self-management support program and usual care, whereas the control group only received the usual nursing care.Result: 35 subjects in the experimental group and 35 subjects in the control group completed the program, respectively. The findings indicated that there are significantly differences in dietary behavior (p=.00), exercise behavior (p=.00) and clinical outcomes: fasting blood glucose (FBG) (p=.00), cholesterol total level (p=.01) and systolic blood pressure (p=.00) between the experimental group and control group. However, for the BMI status (p=.84) and diastolic blood pressure (BP) (p=.32) were no significant differences between two groups. Conclusion: The dietary and exercise self-management support program was effective for improving the dietary behavior, exercise behavior, FBG, and total cholesterol level for individuals with poorly controlled type 2 diabetes mellitus. Further studies should be replicated using larger groups over a longer time frame.
Contributing Factors in Increasing Health Care Associated Infection (Hai’s) in Phlebitis Cases
Authors: Theresia Siwi Ikaristi Maria , Wardani Yulia
Published: July 2017

Backgrounds: One significant problem in hospital is Health Care Associated Infection (HAI’s)  and it gives many effects on  patients health status.Purpose: This study was aimed to examine the incidence rate of phlebitis, the procedures of IV insertion and the factors that influence the phlebitis case in-patient department at the hospital.Methods: The main method used in this study is descriptive explorative. Started by giving training education for 15 nursing staff , medical doctor and pharmacists. Then they were obseved in doing the procedures of  IV incertion, care and documentation by Using Visual Infusion Phlebitis ( VIP) scale then followed by case studies to have clear results in describing the contribution factors which influence the phlebitis incidents.Result: 35 subjects in the experimental group and 35 subjects in the control group completed The result represents that 7 from 72 patients (9,7%) were suffer from phlebitis, 25 patients (34,7%) with IV insertion were not monitored well,  5% nurses did not do the hand washing, 78% did not use the skin perlak for preventing blood to the bed linen. The mode of desinfection direction were 44% circular, 55 % from distal to proximal part, and 11% did not do the desinfectant. 100% the nurses did not documentate the IV monitoring such as the swelling, redness, the size of IV canule and any other skin symptoms of phlebitis. Some medication, insertion side of IV canule on the metacarpal area and flushing procedures were also determinant factor that lead to phlebitis cases.Conclusion: This study conclude that the treatment, care and monitoring IV insertion is a significant and important procedures to prevent phlebitis and automatically becomes an important aspect in preventing Health Care Associated Infection (HAI’s)  rate in hospital.
A Systematic Review of the Selected Evidences on the Effectiveness of Inter-professional Education (IPE) in Developing Interprofessional Learning Environment
Authors: Al Harthy Said Nasser , Al Subhi Najla , Tuppal Cyruz , Reñosa Mark Donald
Published: July 2017

Purpose: This systematic review aimed to provide available evidence in determining for the effectiveness of IPE as a modality in developing interprofessional learning environment for healthcare students.Methods: The computerized searches from 2009-2015 in ten electronic databases were performed. Two independent reviewers were consulted to assess the eligibility, level of evidences and methodological quality in each study. Result: nine out of ten studies were retrieved. These studies include (a) two RCT studies; scored eight and seven out of eight, (b) Three quasi-experimental pretestposttest design; scored seven, six, and six out of eight, (c) Three controlled before and after study; scored six, six, five and five out of eight, and (d) one controlled longitudinal; scored six out of eight respectively.Conclusion: Based on the systematic review, evidence showed that IPE was effective in building strong interprofessional learning environment. On the other hand, the authors recommend considering conduct of similar systematic review grounded on IPE with larger sample size within the health allied discipline.
Modified Pro-Self Pain Control to Increase Activity in Patients with Colorectal Cancer
Authors: Munawaroh Khoirunnisa’ , Sujianto Untung , Mardiyono Mardiyono
Published: July 2017

Background: Barriers to performing activities of daily living are common complaints of patients with cancer. One of the factors causing these barriers is pain. A modified pro-self pain control is a method used to enhance the patients’ ability to cope with pain to increase their activity.Purpose: This study aimed to evaluate the modified pro-self pain control to increase activity in patients with colorectal cancer undergoing chemotherapy.Methods: The present study employed an experimental design. Patients with colorectal cancer undergoing chemotherapy were randomly assigned to the intervention group (n=24) and the control group (n=24). The patients in the control group were given a standard hospital intervention, while the patients in the intervention group were given the modified pro-self pain control for nine days. The data were collected using the instrument of KATZ index and analyzed using the independent t-test.Results: The result of this study showed that there was a higher increase of activity among the patients in the intervention group than in the control group. Independent t-test showed that there was a significant difference between the intervention group and the control group (p=0.00).Conclusion: The modified pro-self pain control was found more effective to increase the activity in patients with colorectal cancer undergoing chemotherapy than that of the standard hospital intervention.
Structuraland antigenic analysis of a new Rhoptry Pseudokinase Gene (ROP54) in Toxoplasma gondii
Authors: Zhou Jian , Lu Gang , Wang Lin , Zhou Aihua H. , Han Yali L. , Guo Jingjing J. , Song Pengxia X. , Zhou Huaiyu Y. , Cong Hua , Hou Ming , He Shenyi Y.
Published: July 2017

is defined as an obligate intracellular apicomplexan parasite and influences approximatelyone-third of the human all over the world. ROP54 protein is expressed in the rhoptry of
Epidemiology of Toxoplasma gondii infection in native Tibetans in Tibet, China
Authors: Li Kun , Wang Meng , Zhang Hui , Lei Zhixin , Zhang Lihong , Luo Houqiang , Qiu Gang , Mehmood Khalid , Shahzad Muhammad , Li Jiakui
Published: July 2017

(
The Prevalence of Cyclospora cayetanensis and Cryptosporidium spp. in Turkish patients infected with HIV-1
Authors: Uysal Hayriye Kirkoyun , Adas Gokhan Tolga , Atalik Kevser , Altiparmak Semih , Akgul Ozer , Saribas Suat , Gurcan Mert , Yuksel Pelin , Yildirmak Taner , Kocazeybek Bekir , Ziver Tevhide , Oner Yasar Ali
Published: July 2017

Opportunistic infections such as cryptosporidiosis and cyclosporiasis are commonly encountered in patients with acquired immunodeficiency syndrome (AIDS). We investigated the existence of opportunistic protozoans that significantly affect the quality of life in HIV-1 infected patients using conventional and molecular methods. The study group comprised 115 HIV-1 positive patients. In the identification of
Intestinal coccidian parasites as an underestimated cause of travellers’ diarrhoea in Polish immunocompetent patients
Authors: Kłudkowska Matylda , Pielok Łukasz , Frąckowiak Krystyna , Paul Małgorzata
Published: July 2017

Intestinal coccidian parasites are intracellular protozoa most frequently transmitted during food-borne and water-borne infections. This group of parasites is responsible for acute diarrhoeal illnesses especially among immunocompromised patients. However, they are more frequently detected in immunocompetent individuals including travellers, and they should also be considered as important etiologic factors of travellers’ diarrhoea. We examined 221 immunocompetent patients hospitalized due to acute or chronic diarrhoea and other gastrointestinal symptoms after returning from international journeys to hot climates. A basic microscopical examination and acid – fast staining of stool samples was performed. Each patient was also a part of the epidemiological investigation to define potential risk factors of tropical gastrointestinal infections. Intestinal coccidiosis was confirmed in 12 out of 221 successively hospitalized patients (5.4%). The most common coccidian parasite was
In vitro and in vivo studies of nematophagous fungi Arthrobotrys musiformis and Arthrobotrys robusta against the larvae of the trichostrongylides
Authors: Cai Kui Zheng , Wang Bo Bo , Xu Qiang , Liu Jun Lin , Wang Kang Ying , Xue Yu Jia , Zhang Hai Yan , Wang Hai Yu , Cao Xin , Ma Zhong Ren
Published: July 2017

Six isolates of
New and previously described dactylogyrid species (Monogenoidea: Polyonchoinea) and a gastrocotylinean pre-adult (Heteronchoinea) from pomacentrid and caesionid (Perciformes) fishes from Lizard Island, Great Barrier Reef, Australia
Authors: Mendoza-Franco Edgar F. , Binning Sandra A. , Roche Dominique G.
Published: July 2017

During a parasitological survey of perciform fishes from Lizard Island, Great Barrier Reef, Australia, we found the following gill monogenoidean species (Platyhelminthes):
Local environmental NGO roles in biodiversity governance: a Czech-German comparison
Authors: Slavíková Lenka , Syrbe Ralf-Uwe , Slavík Jan , Berens Astrid
Published: July 2017

Recently, the role of nongovernmental organizations (NGOs)s in environmental governance has been widely investigated, especially regarding the issue of mandatory public participation in policy-making within a European context. This paper aims to redirect scientific attention from their pure participation to their field actions, i.e., to the role they play in actual natural resource management, especially at the local level, and reframe local environmental NGO roles and positions based on the criteria for scale and influence. More specifically, this paper seeks to identify factors that promote NGOs as effective complements in the protection of state biodiversity and stresses local impacts of different governance schemes.

Determining factors were investigated through a series of in-depth case studies undertaken in the Czech-German border region of the eastern Krušné hory Mts. (Erzgebirge, Ore Mts.). Rather than a quantitatively oriented survey among NGOs, this study focused primarily on a specific territory and, subsequently, on the identification of relevant actor performance (including NGO representatives) within this territory. The method applied for comparison was the Institutional Analysis and Development Framework (IAD Framework). This design enabled a comparison of different social practices in the homogeneous ecosystem present on both sides of the border and captured the influence of specific social and historical cross-border features on environmental NGO performance.
Full box spaces of free groups
Authors: Delabie Thiebout
Published: July 2017

In this paper we investigate full box spaces and coarse equivalences between them. We do this in two parts. In part one we compare the full box spaces of free groups on different numbers of generators. In particular, the full box space of a free group

F
k

{F_{k}}

is not coarsely equivalent to the full box space of a free group

F
d

{F_{d}}

, if

d
≥

8
⁢
k

+
10

{d\geq 8k+10}

. In part two we compare

□
f

⁢

ℤ
n

{\Box_{f}\mathbb{Z}^{n}}

to the full box spaces of 2-generated groups. In particular, we prove that the full box space of

ℤ
n

{\mathbb{Z}^{n}}

is not coarsely equivalent to the full box space of any 2-generated group, if

n
≥
3

{n\geq 3}

.
Sparse signal recovery with prior information by iterative reweighted least squares algorithm
Authors: Feng Nianci , Wang Jianjun , Wang Wendong
Published: July 2017

In this paper, the iterative reweighted least squares (IRLS) algorithm for sparse signal recovery with partially known support is studied. We establish a theoretical analysis of the IRLS algorithm by incorporating some known part of support information as a prior, and obtain the error estimate and convergence result of this algorithm. Our results show that the error bound depends on the best

(

s
+
k

)

{(s+k)}

-term approximation and the regularization parameter λ, and convergence result depends only on the regularization parameter λ. Finally, a series of numerical experiments are carried out to demonstrate the effectiveness of the algorithm for sparse signal recovery with partially known support, which shows that an appropriate q (

0
<
q
<
1

{0<q<1}

) can lead to a better recovery performance than that of the case

q
=
1

{q=1}

.
Inverse problems in Pareto’s demand theory and their applications to analysis of stock market crises
Authors: Klemashev Nikolay I. , Shananin Alexander A. , Zhang Shuhua
Published: July 2017

We develop an approach to the analysis of stock market crises based on
the generalized nonparametric method. The generalized nonparametric method is based on solvability and regularization of ill-posed inverse problem in Pareto’s demand theory. Our approach allows one to select a few companies that may be considered as the main reason for the crisis. We apply this approach to study the Chinese stock market crash in 2015.
Crystal structure of poly[(thiophene-3,4-dicarboxylato-κ1
O)bis[1,2-bis(4-pyridyl)ethane-κ2
N:N′]silver(I)] octahydrate, C30H42Ag2N4O12S
Authors: Liu Xue-Guo , Yan Wei-Hong , Fan Hui-Tao , Qin Teng-Teng
Published: July 2017

C30H42Ag2N4O12S, monoclinic, Pc (no. 7), a = 11.4150(3) Å, b = 17.3038(9) Å, c = 9.3802(5) Å, β = 104.701(4)°, V = 1792.15(14) Å3, Z = 2, R
gt(F) = 0.0320, wR
ref(F
2) = 0.0638, T = 293(2) K.
A implantação da Usina Hidrelétrica de Itaipu Binacional (Brasil/Paraguai) e a disputa pela terra no Brasil na década de 1970: entre a história e a memória
Authors: Ribeiro Maria de Fátima Bento
Published: July 2017

A instalação da hidrelétrica de Itaipu, na fronteira do Brasil com Paraguai, transformou-se em um episódio importante na história contemporânea, pois foi um projeto considerado de maior impacto na história de transformação da natureza e da ecologia do planeta, visto que a usina representou um impacto ambiental e de prejuízos humanos. Neste texto, temos o objetivo de analizar o discurso presente na Obra Entre a Cruz e a Política querelata eventos durante operíodo de instalação da Itaipu, contextualizando toda uma época. Tal discurso refletea questão da luta pela terra, do fortalecimento da oposição e seu crescimento nas cidades do oeste paranaense, principalmente com a formação do MDB naquela região. De modo geral, são memórias do cotidiano que ganham vida no interior de um discurso narrativo, e este material se faz importante para que a memória, na perspectiva das lutas populares, não caia no esquecimento.
O realismo atávico de John J. Mearsheimer: breve ensaio teórico
Authors: Moreira Felipe Kern
Published: July 2017

O propósito do presente artigo é estabelecer considerações sobre alguns dos pressupostos teórico-metodológicos apresentados na obra ‘The Tragedy of Great Power Politics’, de John J. Mearsheimer. Para tal, situa o realismo ofensivo no campo teórico e registra observações críticas sobre pressupostos e opções metodológicas de John J. Mearsheimer.
Sobre a função semântica dos predicados
Authors: Braida Celso R.
Published: July 2017

Nesse texto são apresentadas as propostas de Davidson (2005) e de Puntel (2008) sobre o conteúdo semântico sentencial e o conceito de predicado. Na ortodoxia semântica, a função semântica dos predicados é distinta da função semântica dos designadores, o que implica que uma sentença expresse um conteúdo semântico estruturado. As propostas de Davidson e de Puntel são ambas reelaborações da proposta de Tarski (1983), pela qual as expressões predicativas são derivadas do conceito mais primitivo de sentença aberta, e do primado da verdade sentencial sobre os demais conceitos semânticos. A consequência de ambas as teorias é a eliminação do conceito de predicado e também a dispensa da tese da estruturalidade do conteúdo semântico. Sugere-se a recusa dessas propostas sob o argumento de que elas são incompatíveis com as melhores teorias tanto linguísticas e quanto formais. O ponto crítico está na eliminação da diferença lógica e gramatical entre indicar um objeto sem determiná-lo (nomear) e indicar um objeto por meio de uma determinação ou classificação (predicar), diferença essa refletida na distinção entre termo singular e termo geral na semântica tarskiana, os quais ambos são necessários para compor um termo sentencial que pode ser verdadeiro ou falso.
ASSISTÊNCIA NUTRICIONAL AMBULATORIAL AO GRUPO MATERNO INFANTIL: RELATÓRIO DE ATIVIDADES
Authors: Rodrigues Cardozo Natalia , Weber Bordini Fernanda , Dos Santos Rosa Xavier Mariele , Dutra Valério Inaê , Madruga Peres Andriele , Torres do Vale Oliveira Thays , Da Costa Valle Sandra , Dos Santos Vaz Juliana
Published: July 2017

O presente relatório visa a descrever as ações desenvolvidas pelo projeto de extensão “Assistência nutricional ambulatorial a crianças” desenvolvido pela Faculdade de Nutrição junto ao ambulatório de Pediatria da Faculdade de Medicina (FAMED) da Universidade Federal de Pelotas (UFPel). O projeto tem como objetivo principal realizar atendimento nutricional a crianças e gestantes encaminhados pelos serviços de Pediatria e Ginecologia da FAMED e de unidades básicas de saúde da cidade de Pelotas e região. O atendimento é realizado semanalmente, mediante agendamento. Além de atendimentos individualizados, realizam-se ações de atendimento em grupo na perspectiva da educação alimentar e nutricional e saúde bucal. No ano de 2016, 65% das crianças foram encaminhadas com diagnóstico de sobrepeso ou obesidade, 6% desnutrição, 13% autismo - transtorno do déficit de atenção com hiperatividade ou neuropatias - 8% erros alimentar, entre outros. Na supervisão nutricional pré-natal, 46% das mulheres apresentavam obesidade anterior à gestação e foram encaminhadas para manejo do ganho de peso. Nas ações em saúde bucal, 56% das crianças atendidas foram encaminhadas para atendimento em consultório devido à cárie dentária. As ações desse projeto preenchem uma lacuna importante na assistência ambulatorial de crianças e gestantes de alto risco na comunidade de Pelotas e região.
DISCUSSÃO DOS PRECEITOS DA ATENÇÃO PRIMÁRIA À SAÚDE E DIREITOS HUMANOS EM UMA ATIVIDADE EXTENSIONISTA DE GRADUAÇÃO
Authors: Vinholes Filho Ubirajara Amaral , König Déborah Silveira , Silveira Denise Silva da , Fiori Nádia Spada
Published: July 2017

Este trabalho trata de uma discussão sobre dois casos acompanhados durante o estágio curricular do curso de Medicina no que tange aos conceitos de Atenção Primária à Saúde (APS) e suas intersecções com a Declaração Universal dos Direitos Humanos (DUDH). Sua elaboração dá-se pelacrença de que os preceitos e diretrizes da APS são ferramentas essenciais para possibilitar um existir ao usuário de acordo com o que é pregado pela DUDH. Para tanto, usou-se uma abordagem qualitativa em uma série de dois relatos de casos obtidos a partir da vivência de estágio trimestral de dois alunos de medicina em uma Unidade Básica de Saúde (UBS), Escola vinculada à Universidade Federal de Pelotas (UFPel). Após apresentação, exposição da evolução e discussão dos casos, conclui-se que os princípios da APS foram aplicados, de forma a proporcionar um cuidado integral, multiprofissional e qualificado aos pacientes, apesar de alguns entraves logísticos.
Entrevista com César Victora: Uma Carreira Dedicada a Transformar a Realidade Social
Authors: Victora César
Published: July 2017

Na década de 1980, o Professor César Victora liderava o estudo epidemiológico que iria relacionar a amamentação à prevenção da mortalidade infantil.  Os resultados do estudo impactaram no surgimento de políticas mundiais sobre o aleitamento nos seis primeiros meses de vida. Portanto, nos seus mais de 30 anos liderando pesquisas que mudaram a realidade de  muitas crianças e jovens, no Brasil e no mundo, o recente destaque advindo do Prêmio Gairdner de Saúde Global , contempla a trajetória do professor, que aponta e destaca como a produção do conhecimento e a universidade podem estar a favor de uma sociedade melhor.
INTERNATO EXTRACURRICULAR EM OBSTETRÍCIA NA MATERNIDADE DO HOSPITAL ESCOLA UFPEL
Authors: Blank Camila Hartmann , Longo da Silva Celene Maria , Kubaski Fernanda Coutinho , Menezes Luísa Barin , Giusti Renata Vernetti
Published: July 2017

O projeto de ensino “Internato Extracurricular em Obstetrícia na Maternidade do Hospital Escola UFPEL” foi desenvolvido com o objetivo de inserir os estudantes já no início de sua graduação em um ambiente hospitalar. O projeto extracurricular ocorre no Hospital Escola da UFPel, e os estudantes vivenciam as rotinas práticas de uma maternidade com portas abertas 24horas, elucidando e ilustrando os conteúdos teóricos apresentados nas disciplinas curriculares do curso de medicina da UFPEL. Assim, o aluno aprende a prática da Ginecologia e Obstetrícia de maneira segura e produtiva junto aos professores e aos profissionais em formação da área.