bluuebunny/crossref_metadata_2025 huggingface dataset:
Professional Identity, Career Planning and Professional Development Among Middle School Teachers
Authors: Jisong Jiang
Published: December 2024

This paper was intended to find out the professional identity, career planning and professional development of more than 400 middle school teachers in China. The final research results showed that majority of the respondents were male, 26-35 years old, bachelor’s degree holders, and have been serving the school for 21 years and above. Middle school teachers generally have a positive cognition of their professional identity, especially in terms of professional behavior and professional cognition. They generally have a positive cognition of career planning, especially in terms of continuing learning and career exploration as well as in their professional development, especially in terms of professional affection and competence. Sex, age, educational attainment, and length of service have varying impacts on professional identity and professional development. Significant correlations are identified among three variables and indicate that the higher the professional identity. The study proposed a Proposed Training and Development Plan to help Chinese Middle School Teachers improve their professional identity, career planning and professional development.

This study mainly discussed the role of middle school teachers’ professional identity and career planning in career development as it provided a certain basis for better promoting the development of middle school teachers.
Pendidikan Karakter Anak dalam al-Quran Surat al-A’raf Ayat 31-33
Authors: Nasir M. , Subhi Muhibbul , Samwil Samwil , Ridha Ismu , Gunandar Jerri , Pratama Agus , Ikhsan Ikhsan
Published: December 2024

Al-Quran is the word of Allah SWT, which contains various rules and guidelines for human beings that regulate every aspect of life, including children's personalities. One of the letters about children's personalities is the letter al-A'raf, verses 31-33. In that verse, Allah SWT gives a picture to the believers of how to dress, eat, drink, and do vile things. With regard to the verse, the Qur'an provides an in-depth understanding and understanding of the way of dressing, eating, and drinking that the Sharia permits. This discussion aims to find out the interpretation of surah al-A'raf verses 31-33 related to personality and to know the values ​​of education emphasized in verse. Data collection techniques using literature studies. A child's personality is determined by Islamic education in the family by nurturing and guiding because children are born in a state of nature that requires guidance and direction to awaken a child's potential.
Transformasi Kurikulum Merdeka: Pengembangan Muatan Lokal untuk Meningkatkan Identitas Budaya
Authors: Ridwan Ali  , Mulasi Syibran
Published: December 2024

There are various efforts to increase awareness of local wisdom in Indonesia. This discussion aims to analyze the implementation of local content in schools to create awareness among students in preserving the nation's culture. This research uses a text analysis method relevant to the theme and objectives of the discussion, and data is taken using relevant references, regulations, and the reality that occurs in schools. The discussion results show that in the independent curriculum, educational units can add local content that the regional government has determined by local wisdom or regional characteristics. Provincial governments can allocate regional authority in developing local content curricula based on regional factors. This means that all cultural conditions and regional characteristics have sufficient space to be applied in the curriculum. Therefore, in determining local content options that will be implemented, local governments and schools still refer to applicable regulations and adapt them to the needs of local communities. From these findings, local governments and schools should synergize to maintain the nation's traditional and cultural values by implementing local wisdom in local content lessons in schools
Media Sosial TikTok Dalam Membangun Citra Diri
Authors: Tisa Mutia
Published: December 2024

Tiktok, as a feature on social media applications, has become a phenomenon involving many users in contemporary society. This platform is not just a functional space for interaction and information-seeking; it has also shifted into a symbol of self-image and lifestyle. Symbolic interactionism and consumer society theories can encapsulate this phenomenon, where TikTok is not merely a gathering place but also a stage for expressing, actualizing, and shaping one's self-image. In this context, personal branding emerges as an effort to cultivate a positive image and attract the attention of others. TikTok users actively portray themselves by posting photos and videos to create a positive impression and garner public attention. Despite the gap between social media life and real life, users are willing to purchase likes and followers to maintain their popularity. Thus, the phenomenon of TikTok usage can be analyzed through the perspectives of Darmatugi's theory and new media, especially the theory of use and gratification.
Bjermandsnavne på mineraler
Authors: Jørgensen Gunni
Published: December 2024

Intet resumé
Gamle vindaflejinger
Authors: Kolstrup Else , Thyrsted Tage
Published: December 2024

Intet resumé
Undersøiske rygge vest for Bornholm
Authors: Hamann Niels Erik
Published: December 2024

Intet resumé
Danekræ - hvad er det?
Authors: Madsen Lena
Published: December 2024

Intet resumé
Verdensrummet og muslingerne
Authors: Funder Svend , Weidick Anker
Published: December 2024

Intet resumé
Tertiæret ved Albæk Hoved - et fedt profil
Authors: Heilmann-Clausen Claus
Published: December 2024

Intet resumé
De vestgrønlandske ketilider
Authors: Westphal Niels
Published: December 2024

Intet resumé
Geologi i tidligere Dansk Vestindien
Authors: Jørgensen Gunni
Published: December 2024

Intet resumé
Boganmeldelse. Troels V. Østergaard & Gregers Jensen: STENbogen. 127 sider, Gads Forlag 1993
Authors: Pedersen Gunver K.
Published: December 2024

Intet resumé
Et anderledes klima
Authors: Funder Svend
Published: December 2024

Intet resumé
Anvendelse af iltisotoper i klimaforskning
Authors: Israelson Carsten
Published: December 2024

Intet resumé
Jordens atmosfære, vulkanske gasser og størkning af Gardar bjergartssmelter
Authors: Konnerup-Madsen Jens
Published: December 2024

Intet resumé
Mineralerne i Ivittuut
Authors: Petersen Ole V.
Published: December 2024

Intet resumé
Forklaring søges
Authors: Holm Eigil
Published: December 2024

Intet resumé
Guld
Authors: Østergaard Claus
Published: December 2024

Intet resumé
Pudelave i nogle af verdens ældste bjergarter, Isua, det centrale Vestgrønland,
Authors: Solvang Mette
Published: December 2024

Intet resumé
Verdens ældste dagsommerfugl - om insekter fra moler og Stolleklint ler
Authors: Madsen Henrik , Rust Jens
Published: December 2024

Intet resumé
Boganmeldelse. Per Christiansen: Tyrannosaurerne – Kridttidens superrovdyr, 64 sider. Forlaget Carlsen
Authors: Milàn Jesper
Published: December 2024

Intet resumé
Oceanøer leverer oplysninger fra den nedre kappe: Santo Antão, Kap Verdeøernes hotspot
Authors: Holm Paul Martin
Published: December 2024

Intet resumé
Boganmeldelse. Tove Damholt & Alice Rasmussen: Fossiler fra Faxe Kalkbrud, 44 sider
Authors: Milàn Jesper
Published: December 2024

Intet resumé
Unijne rozporządzenie w sprawie blokowania geograficznego – wiele hałasu o nic?
Authors:   Samodzielny Zakład Europejskiego Prawa Gospodarczego, Wydział Zarządzania Uniwersytetu Warszawskiego, Zoboli Laura
Published: December 2024

Blokowanie geograficzne (geo-blocking) może być definiowane jako instrument cyfrowy mający na celu segmentację internetowych aplikacji zakupowych, ze względu na przynależność państwową klienta, jego miejsce zamieszkania lub prowadzenia działalności. Niniejszy artykuł obejmuje, po pierwsze, tematykę zjawiska blokowania geograficznego w ramach działań podejmowanych przez Komisję Europejskiej, poczynając od strategii jednolitego rynku cyfrowego i następnie koncentrując się na danych zebranych w ramach badania sektora handlu elektronicznego. Po drugie, w artykule omówione zostało również rozporządzenie (UE) 2018/302, które weszło w życie 22 marca 2018 r. i obowiązuje od 3 grudnia 2018 r. Artykuł przede wszystkim porusza tematykę wprowadzonego przez rozporządzenie 2018/302 zakazu blokowania geograficznego i omawia ograniczenia zakresu jego stosowania.
Catamenial pneumothorax: A neglected diagnosis
Authors: Prior C , Rajan S , Naidoo C
Published: December 2024

Background. Catamenial pneumothorax (CP) is an under-reported and misunderstood condition commonly defined as a recurrent, spontaneous pneumothorax occurring from the day before menstruation until 72 hours after its onset. It is the most common clinical manifestation of thoracic endometriosis.
Case report. We describe the case of a 36-year-old woman who presented twice with significant shortness of breath during her menses at a regional hospital in Gauteng Province, South Africa. Chest radiographs showed bilateral spontaneous pneumothoraces on both occasions, indicating a very rare presentation of CP, which is more commonly a right-sided pathology and a rare presentation on its own. Video-assisted thoracoscopic surgery was performed at a tertiary institution. Significant thoracic endometriosis and a diaphragmatic hernia were found, confirming the diagnosis of endometriosis-related CP. Pleurectomy and closure of the diaphragmatic hernia were performed, and the patient was initiated on hormonal therapy.
Conclusion. A high index of clinical suspicion is required for diagnosing CP and its associated conditions. This case highlights the need for awareness of this condition and the importance of long-term follow-up, especially in an overburdened and resource-limited healthcare system.
« C’est là que commence la moralité »
Authors: Frigo Alberto
Published: December 2024

L’éthique de Condillac brille par son absence, ou du moins par l’espace limité qu’elle revêt dans ses textes, et cela malgré le fait que l’abbé reconnaît dans la connaissance des principes de la morale ce qui distingue l’intelligence humaine de l’animale. Malgré les maladresses et les silences, l’approche de Condillac révèle toutefois une démarche cohérente qui analyse la moralité comme un besoin de second degré et qui cherche à reconstituer l’origine et la génération du sentiment du devoir à partir d’une transformation du besoin lui-même.
Agir par devoir et agir par vertu : examen d’une thèse de Rosalind Hursthouse
Authors: Goldstein Pierre
Published: December 2024

La distinction souvent faite entre « éthique des vertus » et « éthique du devoir » a pu laisser penser que les conceptions aristotélicienne et kantienne de la moralité étaient radicalement différentes l’une de l’autre. Cette distinction pourrait justifier que l’on refuse de considérer les motivations de l’action vertueuse comme des motivations « morales » à proprement parler. Pourtant, agir vertueusement, n’est-ce pas, au fond, la même chose qu’agir « par devoir » ? Ainsi, Rosalind Hursthouse peut-elle noter, dès la fin du siècle dernier, que soulève « un enthousiasme grandissant » l’idée selon laquelle « l’agent kantien idéal » et « l’agent néo-aristotélicien idéal » ne sont « pas si différents que ce qu’ils étaient supposés être ». Nous voudrions examiner cette thèse en remontant à ses sources dans certaines interprétations contemporaines de la conception kantienne de l’action accomplie « par devoir ».
Recombination shapes the diversification of the wtf meiotic drivers
Authors: Wang Yan , Xu Hao , He Qinliu , Wu Zhiwei , Gong Zhen , Han Guan-Zhu
Published: December 2024

Meiotic drivers are selfish genetic elements that distort fair segregation. The
wtf
genes are poison-antidote meiotic drivers that are experiencing rapid diversification in fission yeasts. However, gene duplication alone is insufficient to drive the diversification of
wtf
genes, given the poison encoded by a newly duplicated
wtf
gene can be detoxified by the antidote encoded by the original
wtf
gene. Here, we analyze the evolution of
wtf
genes across 21 strains of
Schizosaccharomyces pombe
. Knocking out each of 25
wtf
genes in
S. pombe
strain 972h- separately does not attenuate the yeast growth, indicating that the
wtf
genes might be largely neutral to their carriers in asexual life cycle. Interestingly,
wtf
genes underwent recurrent and intricate recombination. As proof-of-principle, we generate a novel meiotic driver through artificial recombination between
wtf
drivers, and its encoded poison cannot be detoxified by the antidotes encoded by their parental
wtf
genes but can be detoxified by its own antidote. Therefore, we propose that recombination can generate new meiotic drivers and thus shape the diversification of the
wtf
drivers.
Harnessing AlphaFold to reveal hERG channel conformational state secrets
Authors: Ngo Khoa , Yang Pei-Chi , Yarov-Yarovoy Vladimir , Clancy Colleen E , Vorobyov Igor
Published: December 2024

To design safe, selective, and effective new therapies, there must be a deep understanding of the structure and function of the drug target. One of the most difficult problems to solve has been resolution of discrete conformational states of transmembrane ion channel proteins. An example is K
v
11.1 (hERG), comprising the primary cardiac repolarizing current,

I
kr

. hERG is a notorious drug anti-target against which all promising drugs are screened to determine potential for arrhythmia. Drug interactions with the hERG inactivated state are linked to elevated arrhythmia risk, and drugs may become trapped during channel closure. However, the structural details of multiple conformational states have remained elusive. Here, we guided AlphaFold2 to predict plausible hERG inactivated and closed conformations, obtaining results consistent with multiple available experimental data. Drug docking simulations demonstrated hERG state-specific drug interactions in good agreement with experimental results, revealing that most drugs bind more effectively in the inactivated state and are trapped in the closed state. Molecular dynamics simulations demonstrated ion conduction for an open but not AlphaFold2 predicted inactivated state that aligned with earlier studies. Finally, we identified key molecular determinants of state transitions by analyzing interaction networks across closed, open, and inactivated states in agreement with earlier mutagenesis studies. Here, we demonstrate a readily generalizable application of AlphaFold2 as an effective and robust method to predict discrete protein conformations, reconcile seemingly disparate data and identify novel linkages from structure to function.
Visualizing sarcomere and cellular dynamics in skeletal muscle to improve cell therapies
Authors: Hüttemeister Judith , Rudolph Franziska , Radke Michael H , Fink Claudia , Friedrich Dhana , Preibisch Stephan , Falcke Martin , Wagner Eva , Lehnart Stephan E , Gotthardt Michael
Published: December 2024

The giant striated muscle protein titin integrates into the developing sarcomere to form a stable myofilament system that is extended as myocytes fuse. The logistics underlying myofilament assembly and disassembly have started to emerge with the possibility to follow labeled sarcomere components. Here, we generated the mCherry knock-in at titin’s Z-disk to study skeletal muscle development and remodeling. We find titin’s integration into the sarcomere tightly regulated and its unexpected mobility facilitating a homogeneous distribution of titin after cell fusion – an integral part of syncytium formation and maturation of skeletal muscle. In adult mCherry-titin mice, treatment of muscle injury by implantation of titin-eGFP myoblasts reveals how myocytes integrate, fuse, and contribute to the continuous myofilament system across cell boundaries. Unlike in immature primary cells, titin proteins are retained at the proximal nucleus and do not diffuse across the whole syncytium with implications for future cell-based therapies of skeletal muscle disease.
Characterization of cancer-driving nucleotides (CDNs) across genes, cancer types, and patients
Authors: Zhang Lingjie , Deng Tong , Liufu Zhongqi , Chen Xiangnyu , Wu Shijie , Liu Xueyu , Shi Changhao , Chen Bingjie , Hu Zheng , Cai Qichun , Liu Chenli , Li Mengfeng , Tracy Miles E , Lu Xuemei , Wu Chung-I , Wen Hai-Jun
Published: December 2024

A central goal of cancer genomics is to identify, in each patient, all the cancer-driving mutations. Among them, point mutations are referred to as cancer-driving nucleotides (CDNs), which recur in cancers. The companion study shows that the probability of i recurrent hits in n patients would decrease exponentially with i; hence, any mutation with i ≥ 3 hits in The Cancer Genome Atlas (TCGA) database is a high-probability CDN. This study characterizes the 50–150 CDNs identifiable for each cancer type of TCGA (while anticipating 10 times more undiscovered ones) as follows: (i) CDNs tend to code for amino acids of divergent chemical properties. (ii) At the genic level, far more CDNs (more than fivefold) fall on noncanonical than canonical cancer-driving genes (CDGs). Most undiscovered CDNs are expected to be on unknown CDGs. (iii) CDNs tend to be more widely shared among cancer types than canonical CDGs, mainly because of the higher resolution at the nucleotide than the whole-gene level. (iv) Most important, among the 50–100 coding region mutations carried by a cancer patient, 5–8 CDNs are expected but only 0–2 CDNs have been identified at present. This low level of identification has hampered functional test and gene-targeted therapy. We show that, by expanding the sample size to 105, most CDNs can be identified. Full CDN identification will then facilitate the design of patient-specific targeting against multiple CDN-harboring genes.
Skräcklitteratur och självmord
Authors: Fyhr Mattias
Published: December 2024

I artikelns första del diskuteras självmord som motiv och tema i skräcklitteratur sedan medeltiden och framåt och mytologiseringen av verkliga skräckförfattare tas upp. I dess andra del görs en analys av gentlemännens självmord i Machens The Great God Pan utifrån tolkningen att självmorden med snara har en (grekisk) antik koppling och är feminint kodade. Slutligen görs i del 3 en läsning av en trolig intertext kring mystik och (skräck)litterature från E.A. Poes idé i ”The Poetic Principle” om att sann poesi är ett uttryck för den odödliga själens längtan till, och reminiscenser av, livet efter döden, via skönhetsupplevelser i verkliga livet, över Lovecraft, som via snarlika formuleringar förbinder skönheten i bland annat skräcklitteratur med sina upplevelser av arkitektur och ett minne av att han har levt i en stad före universum skapades. Lovecrafts beskrivning återfinns snarlikt i novellen ”The Night Ocean” som skrevs av Lovecrafts litteräre exekutor R.H. Barlow, och jag läser det som att Barlow använder idén på ett nytt sätt, med mer fysiskt kroppslig inriktning och kanske ett homosexuellt självbiografiskt tema.
Non-obese non-alcoholic fatty liver disease and the risk of chronic kidney disease: a systematic review and meta-analysis
Authors: You Yixian , Pei Xiong , Jiang Wei , Zeng Qingmin , Bai Lang , Zhou Taoyou , Lv Xiaoju , Tang Hong , Wu Dongbo
Published: December 2024

Background

Data on risk of developing chronic kidney disease (CKD) between non-obese and obese non-alcoholic fatty liver disease (NAFLD) patients are limited. We aimed to reveal the risk difference of incident CKD between non-obese and obese NAFLD patients.

Methods

We searched PubMed, Embase, and Web of Science databases for studies which reported the incidence of CKD in non-obese and obese NAFLD from inception to 10 March 2024. The primary and secondary outcomes were pooled. Subgroup analysis was used to examine the heterogeneity.

Results

A total of 15 studies were incorporated. The incidence of CKD in non-obese and obese NAFLD were 1,450/38,720 (3.74%) and 3,067/84,154 (3.64%), respectively. Non-obese NAFLD patients had a comparable risk of CKD as obese NAFLD (odds ratio [OR] 0.92, 95% confidence interval [95% CI] [0.72–1.19], I2 = 88%). No differences in estimated glomerular filtration rate and serum creatinine between non-obese and obese NAFLD were found. The mean differences (MD) and 95% CI were 0.01 [−0.02 to 0.04] and 0.50 [−0.90 to 1.90], respectively. In subgroup analyses, non-obese NAFLD had higher eGFR when diagnosed with ultrasound (MD 1.45, 95% CI [0.11–2.79], I2 = 21%). Non-obese NAFLD had higher creatinine in non-Asian (MD 0.06, 95% CI [0.01–0.11], I2 = 55%) and when taking BMI > 30 as the criterion for obesity (MD 0.06, 95% CI [0.00–0.12], I2 = 76%). The occurrence of CKD did not differ when non-obese NAFLD were categorized into overweight and normal-weight types.

Conclusions

Non-obese NAFLD patients experienced the same risk of CKD compared to obese NAFLD.
Congenital Heart Defects in Paediatric Patients with Congenital Urogenital Abnormalities: A Cross-sectional Study
Authors: Khatavkar Sonal , Raveendran Nayana , Vaze Dhananjay Dilip
Published: December 2024

Introduction: Congenital Heart Defects (CHD) are the most significant co-morbidity in children with congenital anomalies of the kidney and urinary tract, according to past research. The fundamental cause is a combination of certain genetic factors and environmental influences on foetal development.

Aim: To investigate the incidence of CHD in congenital urogenital abnormalities in paediatric patients.

Materials and Methods: A cross-sectional study was conducted at Dr. D.Y. Patil Medical College, Pune, Maharashtra, India, from June 2023 to December 2023 on 110 patients with congenital urogenital abnormalities undergoing elective surgical procedures to find the incidence of CHDs. All routine investigations, clinical history and examination, ultrasonography, and echocardiography were done. The association of the variables that were quantitative and not normally distributed in nature was analysed using the Mann-Whitney’s Test, and variables that were quantitative and normally distributed in nature were analysed using an independent t-test. The association of variables which were qualitative in nature was analysed using the Fischer’s-exact test.

Results: The maternal demographic characteristics that were included were maternal age, gestational age, parity, and consanguinity of marriage. The mean maternal age was 25.65±2.79 years. The mean gestational age was 38.55±1.27 weeks. Consanguinity of marriage was observed in four out of 110 cases. Out of 110 cases, the mean primigravida was 37.27%, gravida 2 was 46.36%, gravida 3 was 13.4%, and gravida 4 was 2.73%. The demographic characteristics of children with urogenital anomalies showed a female-to-male ratio of 50:60. Clinically, a murmur was observed in 15% of cases, and other anomalies were detected in two cases. Out of the total 110 patients with urogenital abnormalities, 15 patients had CHD. Among the 15 cases, four cases were Atrial Septal Defects (ASD), six cases were Patent Ductus Arteriosus (PDA), and five cases were Ventricular Septal Defects (VSD). The total incidence of CHDs was 13.6%.

Conclusion: Therefore, authors infered that the incidence of CHD was 13.6% in paediatric patients with congenital urogenital abnormalities. Children with congenital urogenital abnormalities need to be investigated with routine echocardiography. Thus, early diagnosis and therapeutic intervention of CHDs shall not only improve the surgical outcome of congenital urogenital anomalies but also improve the long-term outcome of this highrisk patient population.
A Preliminary Study on Effectiveness of Varying Dose of Paretic Upper Limb Training with Visual Deprivation in Poststroke Patients: A Randomised Clinical Tria
Authors: Pulimoot R Sampath , Bhuvaneswari CKV , Harshavardhan G , Annadurai Kabilan
Published: December 2024

Introduction: Poststroke Upper Limb (UL) rehabilitation with visual deprivation has shown potential in enhancing motor recovery through neural plasticity. However, the optimal dosage remains unclear.

Aim: To evaluate the effectiveness of varying doses of paretic UL training with visual deprivation in stroke patients.

Materials and Methods: This single-centre, parallel-group, single-blinded, randomised clinical trial involved 36 stroke patients who were randomly distributed into three groups varying in treatment frequency: Group A (n=12) received two sessions per week, Group B (n=12) received three sessions per week, and Group C (n=12) received five sessions per week for four weeks. Each session lasted 40 minutes of visual deprivation training for the paretic UL. A trained physiotherapist, who was blinded to group allocation, conducted pre- and postevaluations. The Wolf Motor Function Test was the principal outcome measure. This study utilised Analysis of Variance (ANOVA) for between group comparisons and independent sample t-tests for within group pre-post comparisons, with a significance level of 5%.

Results: Out of the 36 study participants, three dropouts were recorded by the completion of the study: one from Group A and two from Group B. The average age of participants was 54.75±8.06 years, and the duration of stroke was 10.08±4.35 months, with 69.4% experiencing left-sided involvement. All groups showed significant improvement. Group C exhibited the highest improvement in the Wolf Motor Function Test score, with an F value of 42.86 (p-value=0.001). Post-hoc analysis revealed a significant difference in motor score improvement in Group C, (p-value=0.001). Additionally, Group C demonstrated greater improvements in the Wolf Motor Functional Ability Score (WMFAS), with a mean improvement of 15.00±0.82 (F=158.00, p-value=0.001).

Conclusion: Visual deprivation training with higher intensity (five sessions per week) was effective in improving UL motor function in poststroke patients, proving superior to lower intensity (two or three sessions per week). These results highlight the importance of frequent training. Future research with larger and more diverse stroke patient populations, as well as long-term follow-up studies, is needed to validate these findings.
A Rare Case of Dilated Cardiomyopathy in Sjögren’s Syndrome
Authors: Diggikar Pradnya , Pancholi Tushar , Yekkaluru Sreevidya , Reddy Hansini Raju , Jagirdar Akhilesh
Published: December 2024

Dilated Cardiomyopathy (DCM) is a rare but significant complication in patients with primary Sjögren’s Syndrome (pSS), a systemic autoimmune disease that primarily affects the exocrine glands. Cardiac involvement in pSS is uncommon, making the recognition of DCM in these patients crucial for timely intervention. This is a case of a 44-year-old female with well-controlled hypertension who developed progressively worsening shortness of breath, chest pain and bilateral pedal oedema. She also had a two-month history of dry eyes and dry mouth, indicative of sicca symptoms. Clinical examination revealed signs of fluid overload, a pansystolic murmur and sicca features. Electrocardiogram (ECG) and echocardiography demonstrated severe left ventricular dysfunction with an ejection fraction of 15%, consistent with DCM. Laboratory investigations revealed elevated N-terminal pro b-type natriuretic peptide (NT-proBNP) levels and positive anti-Ro52 and anti-La antibodies, pointing to an autoimmune aetiology. Cardiac Magnetic Resonance (CMR) Imaging confirmed non ischaemic DCM, ruling out ischaemic causes. The patient was diagnosed with DCM secondary to pSS. She was treated with diuretics, Angiotensin Converting Enzyme (ACE) inhibitors and immunosuppressive therapy, including methylprednisolone and a tapering course of prednisolone over six months. Significant clinical improvement was observed on follow-up. This case highlights the importance of recognising autoimmune aetiologies, such as pSS, in patients presenting with unexplained cardiomyopathy. Early diagnosis and interdisciplinary management are essential in preventing severe cardiac complications and improving patient outcomes in rare presentations of Sjögren-associated cardiomyopathy
Nutritional and Antinutritional Evaluation of the Pulp and Seed of Terminalia catappa l. (Tropical Almond) Fruit and Physicochemical Properties of Its Seed Oil
Authors: Etame Neola Ntube Ekaney , Ambebe Titus Fondo , Ngwasiri Pride Ndasi , Tiencheu Bernard
Published: December 2024

Aims: This study aimed at determining the nutritional and antinutritional composition of the pulp and seeds as well as physicochemical characteristics of the seed oil of Terminalia catappa L. (tropical almond).
Methodology: The analyses were done in the Agroecology and life science laboratory of the University of Buea between June 2023 and May 2024. The experimental design was employed. Oil was extracted using soxhlet method. UV-visible spectrophotometer was used for nutritional and antinutritinal analyses; while gas chromatography and titrimetry were used to analyse the fatty acid profile and physicochemical properties of the seed oil respectively. 
Results: Results revealed that the seeds recorded more concentrated energy (596.28 Kcal/100g) than the pulps (403.42 Kcal/100g). Total phenolic (133.70 ± 0.15 mg/100g), tannin (77.90 ± 0.01 mg/100g), oxalate (15.01 ± 0.01 mg/100g) and phytic acid (2.81 ± 0.06 mg/100g) contents were displayed by the pulp and 29.70 ± 0.25, 18.00 ± 0.07, 20.92 ± 0.07 and 1.88 ± 0.01 mg/100g, respectively for seeds. The abundant minerals in the pulp were K, Ca, Na, and P, those in the seeds were Mg, K, P and Fe. The Acid value, Saponification value, Iodine value, Peroxide value and P-anisdine value of the seed oil were 2.24 ± 1.16 mgKOH/g, 222.2 ± 3.11 mgKOH/g, 78.50 ± 0.54 gI2/100g, 5.50 ± 0.71 mEq/kg and 3.65 ± 0.23, respectively. Fatty acid profiling showed 66.68% unsaturated fatty acids of which 19.86% and 9.81% were linoleic and linolenic, respectively and 33.32% saturated.
Conclusion: The pulps and seeds of T. catappa have a significantly high content of macro and micronutrients that can meet up the nutritional needs of a population and the quality assessment of the oil suggests that it can be recommended as suitable for industrial usage.
Effect of Environmental Factors and Date of Sowing on Disease Development
Authors: Chaudhary Hem Chandra , Zachharia Sunil , Mayank  , Choudhary Vinay Kumar
Published: December 2024

Understanding the effect of environmental factors and sowing dates on disease development is crucial for optimizing crop health, improving yield, and devising effective, timely disease management strategies in agriculture. The current investigation, which was conducted During 2021 in the laboratory of the Department of Plant Pathology, Naini Agricultural Institute, and Sam Higginbottom University of Agriculture Technology and Sciences. To investigate the impact of environment and date of sowing on development of disease Maydis leaf blight of maize. During Kharif 2021 and 2022, for all four sowing dates, the disease progression of maydis leaf blight on maize variety CML-186 was monitored at weekly intervals beginning at 45 DAS of crop. It can be concluded that the crop stage showed the highest disease incidence at 45, 80, and 87 DAS; consequently, this stage tends to exhibit the most susceptible reaction during Kharif 2021. The crop stage with the highest disease incidence during Kharif 2022 was at 45, 52, and 80 DAS; as a result, this stage typically exhibits the most susceptible response. During Kharif 2021 and 2022, for all four sowing dates, the AUDPC of maydis leaf blight on maize variety CML-186 was noted at weekly intervals beginning at 45 DAS of crop.
CD140b and CD73 are markers for human induced pluripotent stem cell‐derived erythropoietin‐producing cells
Authors: Nishimoto Shogo , Mizuno Tomohiro , Takahashi Kazuo , Nagano Fumihiko , Yuzawa Yukio , Nishiyama Akira , Osafune Kenji , Hitomi Hirofumi , Nagamatsu Tadashi
Published: January 2020

Renal anemia in chronic kidney disease is treated with recombinant human erythropoietin (rhEPO). However, some patients with anemia do not respond well to rhEPO, emphasizing the need for a more biocompatible EPO. Differentiation protocols for hepatic lineages have been modified to enable production from human induced pluripotent stem cell (hiPSC)‐derived EPO‐producing cells (EPO cells). However, markers for hiPSC‐EPO cells are lacking, making it difficult to purify hiPSC‐EPO cells and therefore to optimize EPO production and cell counts for transplantation. To address these issues, we investigated whether CD140b and CD73 could be used as markers for hiPSC‐EPO cells. We measured the expression of EPO, CD140b, and CD73 in hiPSC‐EPO cells and the EPO concentration in the cell supernatant by immunohistochemistry and enzyme‐linked immunosorbent assays on culture day 13, revealing that expression levels of CD140b and CD73 are correlated with the level of EPO. In addition, rates of CD140b+ CD73+ cells were observed to be correlated with the concentration of EPO. Thus, our results suggest that CD140b and CD73 may be markers for hiPSC‐EPO cells.
Low‐intensity pulsed ultrasound inhibits VEGFA expression in chondrocytes and protects against cartilage degeneration in experimental osteoarthritis
Authors: Guan Mengtong , Zhu Ying , Liao Bo , Tan Qiaoyan , Qi Huabing , Zhang Bin , Huang Junlan , Du Xiaolan , Bai Dingqun
Published: January 2020

Low‐intensity pulsed ultrasound (LIPUS), a noninvasive physical therapy, was recently demonstrated to be an effective treatment for osteoarthritis (OA). Vascular endothelium growth factor A (VEGFA) has been found to be upregulated in the articular cartilage, synovium and subchondral bone of OA patients, leading to cartilage degeneration, synovitis and osteophyte formation. However, the functions and mechanisms of LIPUS in regulating chondrocyte‐derived VEGFA expression are still unclear. In this study, we investigated whether LIPUS attenuated OA progression by (a) decreasing the percentage of VEGFA‐positive cells in mouse articular cartilage destabilised through medial meniscus surgery and (b) relieving interleukin‐1β‐induced VEGFA expression in mouse primary chondrocytes. However, this function was negated by a p38 mitogen‐activated protein kinase (p38 MAPK) inhibitor. In addition, we found that LIPUS ameliorated VEGFA‐mediated disorders in cartilage extracellular matrix metabolism and chondrocyte hypertrophy during OA development. In conclusion, our data indicate a novel effect of LIPUS in regulating the expression of osteoarthritic chondrocyte‐derived VEGFA through the suppression of p38 MAPK activity.
Toolkit for MAT in jails and prisons from the National Council
Authors: Knopf Alison
Published: January 2020

The National Council for Behavioral Health has prepared a comprehensive and timely toolkit, Medication Assisted Treatment for Opioid Use Disorder in Jails and Prisons. The 132‐page manual, a copy of which was obtained by ADAW, was written in conjunction with Vital Strategies. It was funded by the Centers for Disease Control and Prevention and headed up by Shannon Mace, senior practice improvement advisor for the National Council.
Boosting H2 Generation Coupled with Selective Oxidation of Methanol into Value‐Added Chemical over Cobalt Hydroxide@Hydroxysulfide Nanosheets Electrocatalysts
Authors: Xiang Kun , Wu Dan , Deng Xiaohui , Li Mei , Chen Shanyong , Hao Panpan , Guo Xuefeng , Luo Jing‐Li , Fu Xian‐Zhu
Published: January 2020

The sluggish kinetics of oxygen evolution reaction (OER) is the main bottleneck for the electrocatalytic water splitting to produce hydrogen (H2), and the by‐product is worthless O2. Therefore, designing a thermodynamically favorable oxidation reaction to replace OER and coupling with value‐added product generation on the anode is of significance for boosting H2 generation under low electrolysis voltage. Herein, cobalt hydroxide@hydroxysulfide nanosheets on carbon paper (Co(OH)2@HOS/CP) are synthesized as bifunctional electrocatalysts to facilitate H2 production and convert methanol to valuable formate simultaneously. Benefiting from the influences/changes on the composition, surface properties, electronic structure, and chemistry of Co(OH)2, the as‐obtained electrodes exhibit very high selectivity for methanol to value‐added formate oxidation (MFO) and boost electrocatalytic performance with low overpotential of 155 mV for MFO and 148 mV for hydrogen evolution reaction at a current density of 10 mA cm−2. Furthermore, the integrated two‐electrode electrolyzer drives 10 mA cm−2 at a cell voltage of 1.497 V with united 100% Faradaic efficiency for anodic and cathodic reaction and continuous 20 h of operation without obvious decay. The electrocatalytic hydrogen production with the assistance of alternative oxidation by the robust electrocatalyst can be further used to realize the upgrading of other organic molecules with less energy consumption.
Advanced Biomaterials and Processing Methods for Liver Regeneration: State‐of‐the‐Art and Future Trends
Authors: da Silva Morais Alain , Vieira Sílvia , Zhao Xinlian , Mao Zhengwei , Gao Changyou , Oliveira Joaquim M. , Reis Rui L.
Published: January 2020

Liver diseases contribute markedly to the global burden of mortality and disease. The limited organ disposal for orthotopic liver transplantation results in a continuing need for alternative strategies. Over the past years, important progress has been made in the field of tissue engineering (TE). Many of the early trials to improve the development of an engineered tissue construct are based on seeding cells onto biomaterial scaffolds. Nowadays, several TE approaches have been developed and are applied to one vital organ: the liver. Essential elements must be considered in liver TE—cells and culturing systems, bioactive agents or growth factors (GF), and biomaterials and processing methods. The potential of hepatocytes, mesenchymal stem cells, and others as cell sources is demonstrated. They need engineered biomaterial‐based scaffolds with perfect biocompatibility and bioactivity to support cell proliferation and hepatic differentiation as well as allowing extracellular matrix deposition and vascularization. Moreover, they require a microenvironment provided using conventional or advanced processing technologies in order to supply oxygen, nutrients, and GF. Herein the biomaterials and the conventional and advanced processing technologies, including cell‐sheets process, 3D bioprinting, and microfluidic systems, as well as the future trends in these major fields are discussed.
A Flexible Carbon Nanotube Sen‐Memory Device
Authors: Qu Ting‐Yu , Sun Yun , Chen Mao‐Lin , Liu Zhi‐Bo , Zhu Qian‐Bing , Wang Bing‐Wei , Zhao Tian‐Yang , Liu Chi , Tan Jun , Qiu Song , Li Qing‐Wen , Han Zheng , Wang Wei , Cheng Hui‐Ming , Sun Dong‐Ming
Published: January 2020

In a modern electronics system, charge‐coupled devices and data storage devices are the two most indispensable components. Although there has been rapid and independent progress in their development during the last three decades, a cofunctionality of both sensing and memory at single‐unit level is yet premature for flexible electronics. For wearable electronics that work in ultralow power conditions and involve strains, conventional sensing‐and‐memory systems suffer from low sensitivity and are not able to directly transform sensed information into sufficient memory. Here, a new transformative device is demonstrated, which is called “sen‐memory”, that exhibits the dual functionality of sensing and memory in a monolithic integrated circuit. The active channel of the device is formed by a carbon nanotube thin film and the floating gate is formed by a controllably oxidized aluminum nanoparticle array for electrical‐ and optical‐programming. The device exhibits a high on–off current ratio of ≈106, a long‐term retention of ≈108 s, and durable flexibility at a bending strain of 0.4%. It is shown that the device senses a photogenerated pattern in seconds at zero bias and memorizes an image for a couple of years.
Formation of Semiconducting Supramolecular Fullerene Aggregates in a Dipeptide Organogel
Authors: Chakraborty Priyadarshi , Ji Wei , Rahmany Stav , Etgar Lioz , Gazit Ehud
Published: January 2020

The formation of nanostructured fullerene aggregate inside supramolecular gels is a topic of great interest because of the potential applications of these nanostructures in photoelectronics. Gel phase facilitates the aggregation of fullerene by restricting the movement of solvent molecules, thereby increasing the local fullerene concentration. Herein, the supramolecular nanostructure formation of fullerene (C60) in a minimalistic dipeptide (diphenylalanine, FF) organogel is reported. The resulting composite FF/Fullerene gels exhibit improved mechanical properties and semiconductivity. While fullerene nanostructures do not disturb the FF aggregation pattern, they adhere to the FF fibers via non‐covalent interaction. Morphological analysis reveals the presence of spherical clusters and nanorods of fullerene attached to the dipeptide fibers. The composite gel with highest fullerene concentration exhibits linear current–voltage response with a current magnitude of ≈0.3 nA. Moreover, poly(3,4‐ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS) is incorporated in the FF/Fullerene system yielding tri‐hybrid donor–acceptor gels which exhibit photoresponsive conductivity. Therefore, the FF/Fullerene and the tri‐hybrid gel have interesting properties, and holds significant promise toward photoelectronic device applications.
A Single‐Step Hot Embossing Process for Integration of Microlens Arrays in Biodegradable Substrates for Improved Light Extraction of Light‐Emitting Devices
Authors: Jürgensen Nils , Fritz Benjamin , Mertens Adrian , Tisserant Jean‐Nicolas , Kolle Mathias , Gomard Guillaume , Hernandez‐Sosa Gerardo
Published: January 2020

Integration of light management solutions relying on biodegradable materials in organic light‐emitting devices could assist the development of sustainable light sources or conformable and wearable display technology. Using industrially relevant processing techniques, it is shown that microlens arrays can be seamlessly integrated into flexible and biodegradable cellulose diacetate substrates to facilitate extraction of the trapped substrate modes in light‐emitting electrochemical cells. The substrates are patterned for light extraction and optimized for scalable printing processes in a single step by thermally embossing microlenses with polydimethylsiloxane molds on one substrate surface and simultaneous flattening of the other. Furthermore, by implementing the biopolymer substrate with microlens arrays, the total volume fraction of biodegradable materials in the microlense equipped device is 99.94%. The embossed microstructures on the biopolymer substrates are investigated by means of scanning electron microscopy and the angular light extraction profile of the devices is measured and compared to ray tracing simulations. Light‐emitting electrochemical cells with integrated microlens array substrates achieve an efficiency enhancement factor of 1.45, exceeding conventional organic light‐emitting diodes on glass substrates with laminated microlens arrays (enhancement factor of 1.23).
Bottom‐Gate Approach for All Basic Logic Gates Implementation by a Single‐Type IGZO‐Based MOS Transistor with Reduced Footprint
Authors: Qi Shaocheng , Cunha Joao , Guo Tian‐Long , Chen Peiqin , Proietti Zaccaria Remo , Dai Mingzhi
Published: January 2020

Logic functions are the key backbone in electronic circuits for computing applications. Complementary metal‐oxide‐semiconductor (CMOS) logic gates, with both n‐type and p‐type channel transistors, have been to date the dominant building blocks of logic circuitry as they carry obvious advantages over other technologies. Important physical limits are however starting to arise, as the transistor‐processing technology has begun to meet scaling‐down difficulties. To address this issue, there is the crucial need for a next‐generation electronics era based on new concepts and designs. In this respect, a single‐type channel multigate MOS transistor (SMG‐MOS) is introduced holding the two important aspects of processing adaptability and low static dissipation of CMOS. Furthermore, the SMG‐MOS approach strongly reduces the footprint down to 40% or even less area needed for current CMOS logic function in the same processing technology node. Logic NAND, NOT, AND, NOR, and OR gates, which typically require a large number of CMOS transistors, can be realized by a single SMG‐MOS transistor. Two functional examples of SMG‐MOS are reported here with their analysis based both on simulations and experiments. The results strongly suggest that SMG‐MOS can represent a facile approach to scale down complex integrated circuits, enabling design flexibility and production rates ramp‐up.
Specific Binding of a d‐RNA G‐Quadruplex Structure with an l‐RNA Aptamer
Authors: Chan Chun‐Yin , Kwok Chun Kit
Published: January 2020

G‐quadruplex (G4) structures are of general importance in chemistry and biology, such as in biosensing, gene regulation, and cancers. Although a large repertoire of G4‐binding tools has been developed, no aptamer has been developed to interact with G4. Moreover, the G4 selectivity of current toolkits is very limited. Herein, we report the first l‐RNA aptamer that targets a d‐RNA G‐quadruplex (rG4). Using TERRA rG4 as an example, our results reveal that this l‐RNA aptamer, Ap3‐7, folds into a unique secondary structure, exhibits high G4 selectivity and effectively interferes with TERRA‐rG4–RHAU53 binding. Our approach and findings open a new door in further developing G4‐specific tools for diverse applications.
Ein hexagonal planarer Metallkomplex
Authors: Tauchert Michael E. , Okuda Jun
Published: January 2020

Ein sechsfach koordinierter Übergangsmetallkomplex vom [ML3Z3]‐Typ mit einer hexagonal‐planaren Geometrie wurde isoliert und charakterisiert. Hierdurch wurde der bisherige Spielraum sechsfach koordinierter Metallkoordinationsverbindungen erweitert, der sich bisher auf oktaedrische und trigonal‐prismatische Geometrien beschränkte.
Isothiourea‐Catalyzed Atropselective Acylation of Biaryl Phenols via Sequential Desymmetrization/Kinetic Resolution
Authors: Munday Elizabeth S. , Grove Markas A. , Feoktistova Taisiia , Brueckner Alexander C. , Walden Daniel M. , Young Claire M. , Slawin Alexandra M. Z. , Campbell Andrew D. , Cheong Paul Ha‐Yeon , Smith Andrew D.
Published: January 2020

Axially chiral phenols are attractive targets in organic synthesis. This motif is central to many natural products and widely used as precursors to, or directly, as chiral ligands and catalysts. Despite their utility few simple catalytic methods are available for their synthesis in high enantiopurity. Herein the atropselective acylation of a range of symmetric biaryl diols is investigated using isothiourea catalysis. Studies on a model biaryl diol substrate shows that the high product er observed in the process is a result of two successive enantioselective reactions consisting of an initial enantioselective desymmetrization coupled with a second chiroablative kinetic resolution. Extension of this process to a range of substrates, including a challenging tetraorthosubstituted biaryl diol, led to highly enantioenriched products (14 examples, up to 98:2 er), with either HyperBTM or BTM identified as the optimal catalyst depending upon the substitution pattern within the substrate. Computation has been used to understand the factors that lead to high enantiocontrol in this process, with maintenance of planarity to maximize a 1,5‐S⋅⋅⋅O interaction within the key acyl ammonium intermediate identified as the major feature that determines atropselective acylation and thus product enantioselectivity.
A Hexagonal Planar Metal Complex
Authors: Tauchert Michael E. , Okuda Jun
Published: January 2020

A six‐coordinate [ML3Z3]‐type transition‐metal complex with a hexagonal planar geometry has been isolated and characterized, extending the scope of six‐coordinate metal coordination compounds to those with a geometry beyond octahedral and trigonal prismatic.