bluuebunny/crossref_metadata_2025 huggingface dataset:
Safety and Efficacy of Mechanical Thrombectomy Using Tigertriever as a Rescue Device After Failed Aspiration—Single Center Experience
Authors: Piasecki Piotr , Wierzbicki Marek , Narloch Jerzy
Published: January 2021

Introduction: We evaluated the safety and efficacy of a new stent retriever—Tigertriever—after failed aspiration.

Materials and Methods: Patients with acute ischemic stroke treated with Tigertriever between January 2018 and March 2020 were included in the study. Treatment results of Tigertriever in rescue therapy (after failed aspiration) were evaluated. Periprocedural data were retrospectively analyzed.

Results: Thirty patients were treated with Tigertriever (14M/16F). There were 20 rescue thrombectomies after failed aspiration. Tigertriver successful recanalization rate (mTICI ≥ 2B) was 70%: 65% in rescue therapy and 80% in first-line therapy. The type of first line treatment had no impact on mRS after 1 month and 3 months (ns). There was significant improvement in NIHSS in all patients (mean NIHSS: 17 vs. 10, p = 0.028), in rescue treatment (mean NIHSS: 17 vs. 11, p = 0.048) and in first line treatment (mean NIHSS: 16 vs. 8, p = 0.0005). Better results in NIHSS at discharge were linked with first pass success (p = 0.002), better mTICI at the end of the procedure (p = 0.0006), and administration of rtPA (p = 0.013).

Conclusions: The new stent retriever Tigertriever is an efficient and safe tool to be used as a rescue device after an unsuccessful first line aspiration technique.
Cognitive Processes Underlying Verbal Fluency in Multiple Sclerosis
Authors: Delgado-Álvarez Alfonso , Matias-Guiu Jordi A. , Delgado-Alonso Cristina , Hernández-Lorenzo Laura , Cortés-Martínez Ana , Vidorreta Lucía , Montero-Escribano Paloma , Pytel Vanesa , Matias-Guiu Jorge
Published: January 2021

Background: Verbal fluency (VF) has been associated with several cognitive functions, but the cognitive processes underlying verbal fluency deficits in Multiple Sclerosis (MS) are controversial. Further knowledge about VF could be useful in clinical practice, because these tasks are brief, applicable, and reliable in MS patients. In this study, we aimed to evaluate the cognitive processes related to VF and to develop machine-learning algorithms to predict those patients with cognitive deficits using only VF-derived scores.

Methods: Two hundred participants with MS were enrolled and examined using a comprehensive neuropsychological battery, including semantic and phonemic fluencies. Automatic linear modeling was used to identify the neuropsychological test predictors of VF scores. Furthermore, machine-learning algorithms (support vector machines, random forest) were developed to predict those patients with cognitive deficits using only VF-derived scores.

Results: Neuropsychological tests associated with attention-executive functioning, memory, and language were the main predictors of the different fluency scores. However, the importance of memory was greater in semantic fluency and clustering scores, and executive functioning in phonemic fluency and switching. Machine learning algorithms predicted general cognitive impairment and executive dysfunction, with F1-scores over 67–71%.

Conclusions: VF was influenced by many other cognitive processes, mainly including attention-executive functioning, episodic memory, and language. Semantic fluency and clustering were more explained by memory function, while phonemic fluency and switching were more related to executive functioning. Our study supports that the multiple cognitive components underlying VF tasks in MS could serve for screening purposes and the detection of executive dysfunction.
Regulatory Master Genes Identification and Drug Repositioning by Integrative mRNA-miRNA Network Analysis for Acute Type A Aortic Dissection
Authors: Fang Junjun , Pan Zongfu , Yu Hao , Yang Si , Hu Xiaoping , Lu Xiaoyang , Li Lu
Published: January 2021

Acute type A aortic dissection (ATAAD) is a life-threatening disease. The understanding of its pathogenesis and treatment approaches remains unclear. In the present work, differentially expressed genes (DEGs) from two ATAAD datasets GSE52093 and GSE98770 were filtered. Transcription factor TEAD4 was predicted as a key modulator in protein-protein interaction (PPI) network. Weighted correlation network analysis (WGCNA) identified five modules in GSE52093 and four modules in GSE98770 were highly correlated with ATAAD. 71 consensus DEGs of highly correlated modules were defined and functionally annotated. L1000CDS2 was executed to predict drug for drug repositioning in ATAAD treatment. Eight compounds were filtered as potential drugs. Integrative analysis revealed the interaction network of five differentially expressed miRNA and 16 targeted DEGs. Finally, master DEGs were validated in human ATAAD samples and AD cell model in vitro. TIMP3 and SORBS1 were downregulated in ATAAD samples and AD cell model, while PRUNE2 only decreased in vitro. Calcium channel blocker and glucocorticoid receptor agonist might be potential drugs for ATAAD. The present study offers potential targets and underlying molecular mechanisms ATAAD pathogenesis, prevention and drug discovery.
Regulation Mechanisms of Expression and Function of Organic Cation Transporter 1
Authors: Ciarimboli Giuliano
Published: January 2021

The organic cation transporter 1 (OCT1) belongs together with OCT2 and OCT3 to the solute carrier family 22 (SLC22). OCTs are involved in the movement of organic cations through the plasma membrane. In humans, OCT1 is mainly expressed in the sinusoidal membrane of hepatocytes, while in rodents, OCT1 is strongly represented also in the basolateral membrane of renal proximal tubule cells. Considering that organic cations of endogenous origin are important neurotransmitters and that those of exogenous origin are important drugs, these transporters have significant physiological and pharmacological implications. Because of the high expression of OCTs in excretory organs, their activity has the potential to significantly impact not only local but also systemic concentration of their substrates. Even though many aspects governing OCT function, interaction with substrates, and pharmacological role have been extensively investigated, less is known about regulation of OCTs. Possible mechanisms of regulation include genetic and epigenetic modifications, rapid regulation processes induced by kinases, regulation caused by protein–protein interaction, and long-term regulation induced by specific metabolic and pathological situations. In this mini-review, the known regulatory processes of OCT1 expression and function obtained fromin vitroandin vivostudies are summarized. Further research should be addressed to integrate this knowledge to known aspects of OCT1 physiology and pharmacology.
Role of GABRD Gene Methylation in the Nucleus Accumbens in Heroin-Seeking Behavior in Rats
Authors: Hong Qingxiao , Xu Wenjin , Lin Zi , Liu Jing , Chen Weisheng , Zhu Huaqiang , Lai Miaojun , Zhuang Dingding , Xu Zemin , Fu Dan , Zhou Wenhua , Liu Huifen
Published: January 2021

Epigenetic modifications such as DNA methylation play important roles in regulating gene expression and may mediate neuroplasticity and lead to drug-induced aberrant behaviors. Although several brain regions and neurobiological mechanisms have been suggested to be involved in these processes, there is remarkably little known about the effects of DNA methylation on heroin-seeking behavior. Using a Sprague-Dawley rat model, we show that heroin self-administration resulted in gamma-aminobutyric acid type A receptor subunit delta (GABRD) gene hypomethylation, which was associated with transcriptional upregulation of GABRD in the nucleus accumbens (NAc). Systemic l-methionine (MET) administration significantly strengthened the reinstatement of heroin-seeking behavior induced by heroin priming, whereas intra-NAc injections of the DNA methyltransferase (DNMT) inhibitor 5-aza-2′-deoxycytidine (5-Aza-dC) had the opposite effect on heroin-seeking. Meanwhile, 5-Aza-dC treatment decreased DNA methylation and upregulated the expression of GABRD in the NAc, whereas MET had the opposite effect. Our results also reveal that 5-Aza-dC might alter the methylation landscape of the GABRD gene by directly repressing DNMT1 and DNMT3A expression. Furthermore, reinstatement of heroin-seeking behavior was significantly inhibited by directly overexpressing GABRD and remarkably reinforced by GABRD gene silencing in the NAc. Collectively, these results suggest that targeting the GABRD gene and its methylation might represent a novel pharmacological strategy for treating heroin addiction and relapse.
The Price of the Induced Defense Against Pests: A Meta-Analysis
Authors: Garcia Alejandro , Martinez Manuel , Diaz Isabel , Santamaria M. Estrella
Published: January 2021

Plants and phytophagous arthropods have co-evolved for millions of years. During this long coexistence, plants have developed defense mechanisms including constitutive and inducible defenses. In an effort to survive upon herbivore attack, plants suffer a resource reallocation to facilitate the prioritization of defense toward growth. These rearrangements usually end up with a penalty in plant growth, development or reproduction directly linked to crop losses. Achieving the balance to maximize crop yield requires a fine tune regulation specific for each host-arthropod combination, which remains to be fully elucidated. The purpose of this work is to evaluate the effects of induced plant defenses produced upon pest feeding on plant fitness and surrogate parameters. The majority of the studies are focused on specific plant-pest interactions based on artificial herbivory damage or simulated defoliation on specific plant hosts. In this meta-analysis, the relevance of the variables mediating plant-pest interactions has been studied. The importance of plant and pest species, the infestation conditions (plant age, length/magnitude of infestation) and the parameters measured to estimate fitness (carbohydrate content, growth, photosynthesis and reproduction) in the final cost have been analyzed through a meta-analysis of 209 effects sizes from 46 different studies. Herbivore infestation reduced growth, photosynthesis and reproduction but not carbohydrate content. When focusing on the analyses of the variables modulating plant-pest interactions, new conclusions arise. Differences on the effect on plant growth and photosynthesis were observed among different feeding guilds or plant hosts, suggesting that these variables are key players in the final effects. Regarding the ontogenetic stage of a plant, negative effects were reported only in infestations during the vegetative stage of the plant, while no effect was observed during the reproductive stage. In addition, a direct relation was found between the durability and magnitude of the infestation, and the final negative effect on plant fitness. Among the parameters used to estimate the cost, growth and photosynthesis revealed more differences among subgroups than reproduction parameters. Altogether, this information on defense-growth trade-offs should be of great help for the scientific community to design pest management strategies reducing costs.
Reversing the Luminance Polarity of Control Faces: Why Are Some Negative Faces Harder to Recognize, but Easier to See?
Authors: Webb Abigail L. M.
Published: January 2021

Control stimuli are key for understanding the extent to which face processing relies on holistic processing, and affective evaluation versus the encoding of low-level image properties. Luminance polarity (LP) reversal combined with face inversion is a popular tool for severely disrupting the recognition of face controls. However, recent findings demonstrate visibility-recognition trade-offs for LP-reversed faces, where these face controls sometimes appear more salient despite being harder to recognize. The present report brings together findings from image analysis, simple stimuli, and behavioral data for facial recognition and visibility, in an attempt to disentangle instances where LP-reversed control faces are associated with a performance bias in terms of their perceived salience. These findings have important implications for studies of subjective face appearance, and highlight that future research must be aware of behavioral artifacts due to the possibility of trade-off effects.
Macphail (1987) Revisited: Pigeons Have Much Cognitive Behavior in Common With Humans
Authors: Zentall Thomas R.
Published: January 2021

The hypothesis proposed by Macphail (1987) is that differences in intelligent behavior thought to distinguish different species were likely attributed to differences in the context of the tasks being used. Once one corrects for differences in sensory input, motor output, and incentive, it is likely that all vertebrate animals have comparable intellectual abilities. In the present article I suggest a number of tests of this hypothesis with pigeons. In each case, the evidence suggests that either there is evidence for the cognitive behavior, or the pigeons suffer from biases similar to those of humans. Thus, Macphail’s hypothesis offers a challenge to researchers to find the appropriate conditions to bring out in the animal the cognitive ability being tested.
Use of Virtual Reality Working Memory Task and Functional Near-Infrared Spectroscopy to Assess Brain Hemodynamic Responses to Methylphenidate in ADHD Children
Authors: Jang Sooah , Choi JongKwan , Oh Jooyoung , Yeom Jungyeon , Hong Narae , Lee Narae , Kwon Joon Hee , Hong Jieun , Kim Jae-jin , Kim Eunjoo
Published: January 2021

Virtual reality (VR) neuropsychological tests have emerged as a method to explore drug effects in real-life contexts in attention deficit hyperactivity disorder (ADHD) children. Functional near-infrared spectroscopy (fNIRS) is a useful tool to measure brain activity during VR tasks in ADHD children with motor restlessness. The present study aimed to explore the acute effects of methylphenidate (MPH) on behavioral performance and brain activity during a VR-based working memory task simulating real-life classroom settings in ADHD children. In total, 23 children with ADHD performed a VR n-back task before and 2 h after MPH administration concurrent with measurements of oxygenated hemoglobin signal changes with fNIRS. Altogether, 12 healthy control (HC) subjects participated in the same task but did not receive MPH treatment. Reaction time (RT) was shortened after MPH treatment in the 1-back condition, but changes in brain activation were not observed. In the 2-back condition, activation of the left dorsolateral prefrontal cortex (DLPFC) and bilateral medial prefrontal cortex (mPFC) was decreased alongside behavioral changes such as shorter RT, lower RT variability, and higher accuracy after MPH administration. Bilateral mPFC activation in the 2-back condition inversely correlated with task accuracy in the pre-MPH condition; this inverse correlation was not observed after MPH administration. In ADHD children, deactivation of the default mode network mediated by mPFC reduced during high working memory load, which was restored through MPH treatment. Our results suggest that the combination of VR classroom tasks and fNIRS examination makes it easy to assess drug effects on brain activity in ADHD children in settings simulating real-life.
Genomic Variation, Evolvability, and the Paradox of Mental Illness
Authors: Gualtieri Camillo Thomas
Published: January 2021

Twentieth-century genetics was hard put to explain the irregular behavior of neuropsychiatric disorders. Autism and schizophrenia defy a principle of natural selection; they are highly heritable but associated with low reproductive success. Nevertheless, they persist. The genetic origins of such conditions are confounded by the problem of variable expression, that is, when a given genetic aberration can lead to any one of several distinct disorders. Also, autism and schizophrenia occur on a spectrum of severity, from mild and subclinical cases to the overt and disabling. Such irregularities reflect the problem of missing heritability; although hundreds of genes may be associated with autism or schizophrenia, together they account for only a small proportion of cases. Techniques for higher resolution, genomewide analysis have begun to illuminate the irregular and unpredictable behavior of the human genome. Thus, the origins of neuropsychiatric disorders in particular and complex disease in general have been illuminated. The human genome is characterized by a high degree of structural and behavioral variability: DNA content variation, epistasis, stochasticity in gene expression, and epigenetic changes. These elements have grown more complex as evolution scaled the phylogenetic tree. They are especially pertinent to brain development and function. Genomic variability is a window on the origins of complex disease, neuropsychiatric disorders, and neurodevelopmental disorders in particular. Genomic variability, as it happens, is also the fuel of evolvability. The genomic events that presided over the evolution of the primate and hominid lineages are over-represented in patients with autism and schizophrenia, as well as intellectual disability and epilepsy. That the special qualities of the human genome that drove evolution might, in some way, contribute to neuropsychiatric disorders is a matter of no little interest.
Toxic Nightlife Relationships, Substance Abuse, and Mental Health: Is There a Link? A Qualitative Case Study of Two Patients
Authors: Racionero-Plaza Sandra , Piñero León Juan Antonio , Morales Iglesias Manuel , Ugalde Leire
Published: January 2021

Introduction and Aims: This article explores the role of toxic close relationships in night life on substance use disorders and mental health conditions. We also contrast the quality and effects of social relationships when doing drugs with those produced by a mental health program that fosters quality relationships between patients.

Design and Methods: This qualitative case study was carried out at a mental health day care center of a hospital in Malaga (Spain). The cases of two patients with severe mental disorders and a history of drug addiction were analyzed. Data were collected through in-depth interviews with every patient, semi-structured interviews about each patient with the psychologist of the medical team of the program, and medical documentation. The analysis involved a combination of inductive and deductive approaches.

Results: The analysis of the data revealed, on the one hand, the influence of toxic relationships in nightlife, including violent sporadic sexual relationships, in the initiation and persistence of substance use that took part of the mental health disorder in these patients. On the other hand, the findings show that these participants' current involvement in a mental health program, which fosters quality relationships between patients, has brought emotional benefits to both of them.

Discussion and Conclusion: This paper points out the relevance of considering quality of social relationships when examining substance use disorders and related mental health problems. Additionally, the findings indicate the importance of fostering quality peer relationships in mental health rehabilitation programs addressed to patients with histories of drug addiction to improve treatment outcome.
Disentangling Trait-Like Between-Individual vs. State-Like Within-Individual Effects in Studying the Mechanisms of Change in CBT
Authors: Zilcha-Mano Sigal , Webb Christian A.
Published: January 2021

Hofmann et al. argued that “[w]hile the clinical field has produced a dizzying number of treatment models and treatment protocols for virtually every psychiatric and psychological problem imaginable, increases in understanding of the processes of change in psychotherapy has been slow to arrive.” We propose that one of the reasons for the slow progress is that prior psychotherapy research conflates trait-like and state-like components of mechanisms of change. Trait-like components can serve as prescriptive or prognostic variables, whereas state-like components reflect within-client processes of change, and may highlight active ingredients of successful treatment. Distinguishing between the two is essential for clarifying the underlying processes of change in psychotherapy, and ultimately identifying empirically-derived individualized treatment targets. We review studies that implement methodological and statistical approaches for disentangling the two. These studies clarified particular mechanisms of change that may operate in a given treatment, highlighted differences in the processes of change between different treatments, and explored the within-individual interplay between different mechanisms of change during treatment. Examples include studies investigating the therapeutic role of behavioral, cognitive, and interpersonal skills, as well as emotional processing. We conclude with suggestions for future research, including attention to diversity, improved measurement to facilitate a reliable and valid estimation of trait-like and state-like components, the use of appropriate statistical approaches to adequately disentangle the two components, integration of theory-driven and data-driven methods of analysis, and the need to experimentally manipulate the state-like changes in a given mechanism of change to strengthen causal inferences.
Source Contribution of Firecrackers Burst vs. Long-Range Transport of Biomass Burning Emissions Over an Urban Background
Authors: Rajput Prashant , Singh Amit Kumar , Biswas Kaniska , Qadri Adnan Mateen , Gupta Tarun
Published: January 2021

This study reports on the high-resolution data set of ground-level O3, surface-bound polycyclic aromatic hydrocarbons (SB-PAHs), and particle's number concentrations (range: 10 to 1,000 nm, referred to as condensation nucleus concentration: CNC) during a Diwali festival campaign (conducted from 08th to 16th Nov.2015) at Kanpur location. In this study, we have made an attempt to assess the change in atmospheric composition and chemistry (based on SB-PAHs, O3, and CNC) during Diwali festival (11th Nov.) and compared the results with pre-Diwali (08th−10th Nov.) and post-Diwali (12th−16th Nov.) scenarios. The wind pattern and cluster analysis have revealed a quite similar feature that from 10th to 16th of November the prevailed winds were north-westerly (NW). It is noteworthy that NW-winds during post-monsoon season (Oct–Nov) favors the long-range transport of biomass burning emissions (LRT-BB) from its source region in upwind Indo-Gangetic Plain (IGP). The influence of LRT-BB emissions at the receptor site during Diwali and post-Diwali period was reflected by the substantial increase in average concentrations of PM2.5, O3 and CNC (difference has been ascertained from a two-tailed t-test). The Lenshchow-type analysis revealed that the firecrackers (FC) burst and LRT-BB emissions have lead to increase the concentrations of CNC by 54% and 86%, respectively over the urban background level. On the other hand, the FC burst and LRT-BB increased the concentrations of O3 by 12% and 31% (over the urban background), respectively. Lenschow-type analysis revealed that FC burst and LRT-BB increased the daily PM2.5 concentration by 11% and 36%, respectively over its urban background level (286 μg m−3). However, the SB-PAHs concentrations were found to be decreased by 6% and 2%, respectively, during the FC burst activity and LRT-BB emissions. Based on the observations pertaining to the decrease in SB-PAHs concentrations from the Lenschow-type analysis and anti-correlation between SB-PAHs and O3 the heterogeneous-phase chemical reactivity and loss of SB-PAHs has been inferred in this study.
Modeling the Ruminant Placenta-Pathogen Interactions in Apicomplexan Parasites: Current and Future Perspectives
Authors: Pastor-Fernández Iván , Collantes-Fernández Esther , Jiménez-Pelayo Laura , Ortega-Mora Luis Miguel , Horcajo Pilar
Published: January 2021

Neospora caninum and Toxoplasma gondii are one of the main concerns of the livestock sector as they cause important economic losses in ruminants due to the reproductive failure. It is well-known that the interaction of these parasites with the placenta determines the course of infection, leading to fetal death or parasite transmission to the offspring. However, to advance the development of effective vaccines and treatments, there are still important gaps on knowledge on the placental host-parasite interactions that need to be addressed. Ruminant animal models are still an indispensable tool for providing a global view of the pathogenesis, lesions, and immune responses, but their utilization embraces important economic and ethics restrictions. Alternative in vitro systems based on caruncular and trophoblast cells, the key cellular components of placentomes, have emerged in the last years, but their use can only offer a partial view of the processes triggered after infection as they cannot mimic the complex placental architecture and neglect the activity of resident immune cells. These drawbacks could be solved using placental explants, broadly employed in human medicine, and able to preserve its cellular architecture and function. Despite the availability of such materials is constrained by their short shelf-life, the development of adequate cryopreservation protocols could expand their use for research purposes. Herein, we review and discuss existing (and potential) in vivo, in vitro, and ex vivo ruminant placental models that have proven useful to unravel the pathogenic mechanisms and the host immune responses responsible for fetal death (or protection) caused by neosporosis and toxoplasmosis.
Milk Production, Body Weight, Body Condition Score, Activity, and Rumination of Organic Dairy Cattle Grazing Two Different Pasture Systems Incorporating Cool- and Warm-Season Forages
Authors: Ritz Kathryn E. , Heins Bradley J. , Moon Roger D. , Sheaffer Craig C. , Weyers Sharon L.
Published: January 2021

Organic dairy cows were used to evaluate the effect of two organic pasture production systems (temperate grass species and warm-season annual grasses and cool-season annuals compared with temperate grasses only) across two grazing seasons (May to October of 2014 and 2015) on milk production, milk components (fat, protein, milk urea nitrogen (MUN), somatic cell score (SCS)), body weight, body condition score (BCS), and activity and rumination (min/day). Cows were assigned to two pasture systems across the grazing season at an organic research dairy in Morris, Minnesota. Pasture System 1 was cool-season perennials (CSP) and Pasture System 2 was a combination of System 1 and warm-season grasses and cool-season annuals. System 1 and System 2 cows had similar milk production (14.7 and 14.8 kg d−1), fat percentage (3.92% vs. 3.80%), protein percentage (3.21% vs. 3.17%), MUN (12.5 and 11.5 mg dL−1), and SCS (4.05 and 4.07), respectively. Cows in System 1 had greater daily rumination (530 min/day) compared to cows in System 2 (470 min/day). In summary, warm-season annual grasses may be incorporated into grazing systems for pastured dairy cattle.
Study on the Performance of Liquid Metal Lubricated V-Groove Bearing Considering Turbulence
Authors: Xu Mingyu , Chen Wei
Published: January 2021

To study the application of liquid metal (LM) in the field of practical lubrication, the viscosity of gallium based liquid metal (GBLM) was measured initially, and the relationship between viscosity and temperature was fitted to obtain the viscosity under high temperature. Under the simulated high temperature and vacuum working environment of computed tomography tube (CTT) machines, considering the influence of turbulence, the changes, with eccentricity, of bearing capacity, discharge, friction power consumption, temperature rise, stiffness, and critical mass of the GBLM lubricated V-groove bearing (V-g B) were analyzed. Due to the special structure of V-g B, the coordinate transformation was carried out and the turbulent Reynolds equation was solved by using the finite difference method and the local integral method. The bearing film thickness and pressure distribution under the two coordinate systems were analyzed and compared and the pressure distribution of V-g B under small eccentricity and large eccentricity was studied, respectively. The performance of GBLM lubricated V-g B was studied, which provides theoretical guidance and an analytical method for LM bearing of high-performance CT equipment.
Design of a Coplanar Interlayer Gapped Microstrips Arrangement for Multi-Nuclei (1H, 19F, 31P, and 23Na) Applications in 7T MRI
Authors: Hernandez Daniel
Published: January 2021

Seven Tesla Magnetic Resonance (MR) systems can obtain high quality anatomical images using protons (1H) and can be used for multinuclear imaging and MR spectroscopy. These imaging modes can also obtain images and metabolic information using other nuclei, such as 19F, 31P, and 23Na. Here, we present an RF coil unit using a microstrip capable of resonating at four frequencies: 300 (1H), 280 (19F), 121 (31P), and 78 (23Na) MHz. The RF unit consists of a single feeding port and four lines that resonate and run a current at their respective frequency. We used the gapped microstrip concept to isolate each conducting line and interleaved the dielectric materials used for each line, thereby reducing the coupling between them. We also analyzed this design using electromagnetic (EM) simulations, and found that the quad tuned arrangement produced low coupling between adjacent current lines and achieved a uniform |B1| field in the z-y plane.
A Decision Concept to the Historic Pedestrian Bridges Recovery Planning
Authors: Rogulj Katarina , Kilić Pamuković Jelena , Jajac Nikša
Published: January 2021

One of the important segments of pedestrian infrastructure are pedestrian bridges. The importance is greater if these bridges are of historical and cultural significance to the city or region. To manage these bridges, it is important to develop an approach that can enable systematic and organized decision-making for experts and policy makers. Hereby, a recovery of bridges is analyzed for the priority ranking of historic pedestrian bridges. Maps of Europe from XIX. Century for the area of Split-Dalmatia County (SDC) are used to locate the bridges. A total of nine bridges are identified, and a set of relevant criteria are defined to evaluate these bridges. The Analytic Hierarchy Process (AHP) is used for the comparison of criteria, evidential reasoning for the assessment of bridges according to each criterion, and then the Technique for Order of Preference by Similarity to Ideal Solution (TOPSIS) is conducted for priority ranking of bridges for the recovery planning. To achieve the final order of bridges it was crucial to take into account mechanical, dynamical, ecological, financial, and, also, social characteristics of these bridges, which was not an easy task. For this reason, the authors proposed a model of decision support to help policy and decision makers in the managing of recovery activities of historic road bridges. The model was conducted on the bridges in the area of SDC, built until the end of the Austro-Hungarian Monarchy.
Real-Time Monitoring of Environmental Parameters in a Commercial Gestating Sow House Using a ZigBee-Based Wireless Sensor Network
Authors: Zeng Zhixiong , Zeng Fanguo , Han Xiaoteng , Elkhouchlaa Hamza , Yu Qiaodong , Lü Enli
Published: January 2021

Significant intensification in livestock farming has become prevalent to meet the increasing meat production demand, resulting in a higher density of pigs in relatively small areas in a commercial swine building. The subsequent challenges of maintaining the quality of both routine management and environmental comfort of pigs to minimize the loss of both pigs’ health and welfare can be attained by implementing autonomous monitoring and intelligent management decisions based on precision livestock farming (PLF). A three-layer wireless sensor network (WSN) based on ZigBee technology has been devised to monitor four environmental parameters in real-time, namely: temperature, relative humidity, concentrations of carbon dioxide and ammonia in a commercial gestating sow house. The overall packet loss rate of the WSN system which reported 16,371 records from its 41 indoor slave nodes in a 10-min interval for three consecutive days was 4%. The carbon dioxide sensors had an average outlier rate of 6.5% after a series of preprocessing procedures. The spatial and temporal characteristics showed that the carbon dioxide level exceeded the limit of 2700 mg/m3 twice during both 07:00–08:00 and 14:00–15:00. Besides, the overall NH3 concentration in the swine building was maintained in a relatively low-level range with a maximum of less than 8 mg/m3. In sum, the real-time monitoring and timely intervention of microclimate in this commercial gestating sow house can be achieved by deploying this WSN system, thereby making it possible to provide an intelligent decision on precise management of livestock automatically.
Digital Workflow in Maxillofacial Prosthodontics—An Update on Defect Data Acquisition, Editing and Design Using Open-Source and Commercial Available Software
Authors: Cristache Corina Marilena , Tudor Ioana , Moraru Liliana , Cristache Gheorghe , Lanza Alessandro , Burlibasa Mihai
Published: January 2021

Background: A maxillofacial prosthesis, an alternative to surgery for the rehabilitation of patients with facial disabilities (congenital or acquired due to malignant disease or trauma), are meant to replace parts of the face or missing areas of bone and soft tissue and restore oral functions such as swallowing, speech and chewing, with the main goal being to improve the quality of life of the patients. The conventional procedures for maxillofacial prosthesis manufacturing involve several complex steps, are very traumatic for the patient and rely on the skills of the maxillofacial team. Computer-aided design and computer-aided manufacturing have opened a new approach to the fabrication of maxillofacial prostheses. Our review aimed to perform an update on the digital design of a maxillofacial prosthesis, emphasizing the available methods of data acquisition for the extraoral, intraoral and complex defects in the maxillofacial region and assessing the software used for data processing and part design. Methods: A search in the PubMed and Scopus databases was done using the predefined MeSH terms. Results: Partially and complete digital workflows were successfully applied for extraoral and intraoral prosthesis manufacturing. Conclusions: To date, the software and interface used to process and design maxillofacial prostheses are expensive, not typical for this purpose and accessible only to very skilled dental professionals or to computer-aided design (CAD) engineers. As the demand for a digital approach to maxillofacial rehabilitation increases, more support from the software designer or manufacturer will be necessary to create user-friendly and accessible modules similar to those used in dental laboratories.
Intrinsically Motivated Open-Ended Multi-Task Learning Using Transfer Learning to Discover Task Hierarchy
Authors: Duminy Nicolas , Nguyen Sao Mai , Zhu Junshuai , Duhaut Dominique , Kerdreux Jerome
Published: January 2021

In open-ended continuous environments, robots need to learn multiple parameterised control tasks in hierarchical reinforcement learning. We hypothesise that the most complex tasks can be learned more easily by transferring knowledge from simpler tasks, and faster by adapting the complexity of the actions to the task. We propose a task-oriented representation of complex actions, called procedures, to learn online task relationships and unbounded sequences of action primitives to control the different observables of the environment. Combining both goal-babbling with imitation learning, and active learning with transfer of knowledge based on intrinsic motivation, our algorithm self-organises its learning process. It chooses at any given time a task to focus on; and what, how, when and from whom to transfer knowledge. We show with a simulation and a real industrial robot arm, in cross-task and cross-learner transfer settings, that task composition is key to tackle highly complex tasks. Task decomposition is also efficiently transferred across different embodied learners and by active imitation, where the robot requests just a small amount of demonstrations and the adequate type of information. The robot learns and exploits task dependencies so as to learn tasks of every complexity.
Quantifying the Impact of the Covid-19 Lockdown Measures on Nitrogen Dioxide Levels throughout Europe
Authors: Solberg Sverre , Walker Sam-Erik , Schneider Philipp , Guerreiro Cristina
Published: January 2021

In this paper, the effect of the lockdown measures on nitrogen dioxide (NO2) in Europe is analysed by a statistical model approach based on a generalised additive model (GAM). The GAM is designed to find relationships between various meteorological parameters and temporal metrics (day of week, season, etc.) on the one hand and the level of pollutants on the other. The model is first trained on measurement data from almost 2000 monitoring stations during 2015–2019 and then applied to the same stations in 2020, providing predictions of expected concentrations in the absence of a lockdown. The difference between the modelled levels and the actual measurements from 2020 is used to calculate the impact of the lockdown measures adjusted for confounding effects, such as meteorology and temporal trends. The study is focused on April 2020, the month with the strongest reductions in NO2, as well as on the gradual recovery until the end of July. Significant differences between the countries are identified, with the largest NO2 reductions in Spain, France, Italy, Great Britain and Portugal and the smallest in eastern countries (Poland and Hungary). The model is found to perform best for urban and suburban sites. A comparison between the found relative changes in urban surface NO2 data during the lockdown and the corresponding changes in tropospheric vertical NO2 column density as observed by the TROPOMI instrument on Sentinel-5P revealed good agreement despite substantial differences in the observing method.
Performance Assessment of GSMaP and GPM IMERG Products during Typhoon Mangkhut
Authors: Li Xiaoyu , Chen Sheng , Liang Zhenqing , Huang Chaoying , Li Zhi , Hu Baoqing
Published: January 2021

This paper evaluated the latest version 6.0 Global Satellite Mapping of Precipitation (GSMaP) and version 6.0 Integrated Multi-satellitE Retrievals for Global Precipitation Measurement (IMERG) products during 2018 Typhoon Mangkhut in China. The reference data is the rain gauge datasets from Gauge-Calibrated Climate Prediction Centre (CPC) Morphing Technique (CMORPHGC). The products for comparison include the GSMaP near-real-time, Microwave-IR merged, and gauge-calibrated (GSMaP_NRT, GSMaP_MVK, and GSMaP_Gauge) and the IMERG Early, Final, and Final gauge-calibrated (IMERG_ERUncal, IMERG_FRUncal, and IMERG_FRCal) products. The results show that (1) both GSMaP_Gauge and IMERG_FRCal considerably reduced the bias of their satellite-only products. GSMaP_Gauge outperforms IMERG_FRCal with higher Correlation Coefficient (CC) values of about 0.85, 0.78, and 0.50; lower Fractional Standard Error (FSE) values of about 18.00, 18.85, and 29.30; and Root-Mean-Squared Error (RMSE) values of about 12.12, 33.35, and 32.99 mm in the rainfall centers over mainland China, southern China, and eastern China, respectively. (2) GSMaP products perform better than IMERG products, with higher Probability of Detection (POD) and Critical Success Index (CSI) and lower False Alarm Ratio (FAR) in detecting rainfall occurrence, especially for high rainfall rates. (3) For area-mean rainfall, IMERG performs worse than GSMaP in the rainfall centers over mainland China and southern China but shows better performance in the rainfall center over eastern China. GSMaP_Gauge and IMERG_FRCal perform well in the three regions with a high CC (0.79 vs. 0.94, 0.81 vs. 0.96, and 0.95 vs. 0.97) and a low RMSE (0.04 vs. 0.06, 0.40 vs. 0.59, and 0.19 vs. 0.34 mm). These useful findings will help algorithm developers and data users to better understand the performance of GSMaP and IMERG products during typhoon precipitation events.
The Role of Autosensitivity Control (ASC) in Cochlear Implant Recipients
Authors: Di Berardino Federica , Zanetti Diego , Soi Daniela , Costa Lara Dalla , Burdo Sandro
Published: January 2021

The purpose of the study was to examine the subjective and objective potential advantage for speech understanding in noise achieved by cochlear implant (CI) recipients when using the autosensitivity control (ASC) input signal processing in combination with the adaptive dynamic range optimization (ADRO). Eighteen subjects (8 females, 10 males, mean age 17.7 ± 6.7) were enrolled in a prospective open blinded comparative study between the ASC + ADRO condition vs. the ADRO alone; 16 were sequential binaural and 2 were monoaural CI recipients. All patients had been wearing their CI for at least 3 years, had no additional disabilities, had an age-appropriate receptive and expressive language. Word recognition performances in noise (at signal-to-noise ratio +5 dB HL) were significantly better in the ADRO-alone condition than in the ADRO + ASC condition. (p = 0.03) These objective outcomes were in agreement with the subjective reports. No significant difference was found in quiet. Our results, apparently in contrast with other reports in the literature, suggest that the decision of adding the slow-acting automatic reduction in microphone sensitivity provided by ASC should be limited to selected CI recipients.
Human Fatalities Caused by Hornet, Wasp and Bee Stings in Spain: Epidemiology at State and Sub-State Level from 1999 to 2018
Authors: Feás Xesús
Published: January 2021

Epidemiology of fatalities in Spain due to hornet, wasp, and bee stings (Cause Code of Death: X23) is described. Over a 20-year period (1999–2018), a total of 78 fatalities were recorded, mostly occurring in males (85.9%), of 65 years and older (52.6%), at “unspecified places” (67.9%), and in the months of July and August (50%). The X23 mortality rates (X23MR) expressed in terms of annual rates and per million inhabitants, varied from 0.02 to 0.19 (mean value ± standard deviation = 0.09 ± 0.05), placing Spain at low levels in comparison with other countries. A more detailed and specific breakdown of the distribution of the yearly deaths at the sub-state level and across communities reveals some striking features. They were more concentrated in the communities of Galicia (35.8%), Andalucía (21.7%), and Castilla y León (12.8%). X23MR were estimated in Galicia at 1.82, 1.10, and 2.22 in 2014, 2016, and 2018, respectively; and in Asturias at 1.88 and 0.97, in 2014 and 2017, respectively. The role of the invasive species Vespa velutina (VV) is examined. Due to its habits, abundance, and broader distribution, the risk that VV represents to human health is unmatched by other Hymenoptera native species.
δ-Cells: The Neighborhood Watch in the Islet Community
Authors: Gao Rui , Yang Tao , Zhang Quan
Published: January 2021

Somatostatin-secreting δ-cells have aroused great attention due to their powerful roles in coordination of islet insulin and glucagon secretion and maintenance of glucose homeostasis. δ-cells exhibit neuron-like morphology with projections which enable pan-islet somatostatin paracrine regulation despite their scarcity in the islets. The expression of a range of hormone and neurotransmitter receptors allows δ-cells to integrate paracrine, endocrine, neural and nutritional inputs, and provide rapid and precise feedback modulations on glucagon and insulin secretion from α- and β-cells, respectively. Interestingly, the paracrine tone of δ-cells can be effectively modified in response to factors released by neighboring cells in this interactive communication, such as insulin, urocortin 3 and γ-aminobutyric acid from β-cells, glucagon, glutamate and glucagon-like peptide-1 from α-cells. In the setting of diabetes, defects in δ-cell function lead to suboptimal insulin and glucagon outputs and lift the glycemic set-point. The interaction of δ-cells and non-δ-cells also becomes defective in diabetes, with reduces paracrine feedback to β-cells to exacerbate hyperglycemia or enhanced inhibition of α-cells, disabling counter-regulation, to cause hypoglycemia. Thus, it is possible to restore/optimize islet function in diabetes targeting somatostatin signaling, which could open novel avenues for the development of effective diabetic treatments.
The Role of Serum 5-HIAA as a Predictor of Progression and an Alternative to 24-h Urine 5-HIAA in Well-Differentiated Neuroendocrine Neoplasms
Authors: Wedin Maria , Mehta Sagar , Angerås-Kraftling Jenny , Wallin Göran , Daskalakis Kosmas
Published: January 2021

Our aim was to investigate the clinical utility of serum 5HIAA for disease surveillance and diagnostic purposes in a cohort of patients with well-differentiated neuroendocrine neoplasms (WD-NENs). Forty-eight patients with WD-NENs and concurrent serum and urinary 5HIAA testing, as well as CT/MRI imaging, were included. Analysis of matching-pairs did not reveal any association between RECIST 1.1 responses and changes in serum 5HIAA levels (p = 0.673). In addition, no correlation was evident between RECIST 1.1 responses and >10%, >25% or >50% changes in serum 5HIAA levels (Fisher’s exact test p = 0.380, p > 0.999, and p > 0.999, respectively). The presence of liver metastases and extensive liver tumor involvement were associated with higher serum 5HIAA levels (p = 0.045 and p = 0.041, respectively). We also confirmed a strong linear correlation between the measurements of serum and urine 5HIAA (n = 24, r = 0.791, p < 0.0001). The concordance rate of serum and urinary 5HIAA positivity at standardized laboratory cut-offs was 75%. In patients with normal renal function tests, the concordance between the two methods was as high as 89%, and a sensitivity and specificity of 80% and 88.9%, respectively, was evident (Cohen’s kappa coefficient = 0.685). In conclusion, serum 5HIAA performs well compared to urinary testing for diagnostic purposes, mainly in advanced disease stages, and corresponds well to liver tumor burden. However, it is not adequate to predict tumor progression.
Recent Advances of Actinomycetes
Authors: Kim Eung-Soo
Published: January 2021

The discovery and development of actinomycete secondary metabolites (ASMs) have played pivotal roles in the fields of human medicine and its related biotechnology sectors over the past several decades [...]
Heparan Sulfate Glycosaminoglycans: (Un)Expected Allies in Cancer Clinical Management
Authors: Faria-Ramos Isabel , Poças Juliana , Marques Catarina , Santos-Antunes João , Macedo Guilherme , Reis Celso A. , Magalhães Ana
Published: January 2021

In an era when cancer glycobiology research is exponentially growing, we are witnessing a progressive translation of the major scientific findings to the clinical practice with the overarching aim of improving cancer patients’ management. Many mechanistic cell biology studies have demonstrated that heparan sulfate (HS) glycosaminoglycans are key molecules responsible for several molecular and biochemical processes, impacting extracellular matrix properties and cellular functions. HS can interact with a myriad of different ligands, and therefore, hold a pleiotropic role in regulating the activity of important cellular receptors and downstream signalling pathways. The aberrant expression of HS glycan chains in tumours determines main malignant features, such as cancer cell proliferation, angiogenesis, invasion and metastasis. In this review, we devote particular attention to HS biological activities, its expression profile and modulation in cancer. Moreover, we highlight HS clinical potential to improve both diagnosis and prognosis of cancer, either as HS-based biomarkers or as therapeutic targets.