bluuebunny/crossref_metadata_2025 huggingface dataset:
O CONTROLE DE CONSTITUCIONALIDADE NO BRASIL: DA CONSTITUIÇÃO DE 1891 AO NOVO CÓDIGO DE PROCESSO CIVIL
Authors: Da Motta Ivan Dias , De Séllos Knoerr Viviane Côelho , Marques Helio Lucas
Published: April 2020

Este artigo tem como objetivo analisar, o processo histórico que deu origem ao controle jurisdicional de constitucionalidade no Brasil, de como esse sistema evoluiu até constituição de 1988, e como achegada no Novo Código de Processo Civil influenciou em sua estrutura. Diante disso, busca-se fazer uma análise sobre especificando como funciona e quais foram os modelos em que ordenamento jurídico brasileiro se espelhou, no caso os modelos norte-americano e austríaco, para sua implementação. No que tanque o controle de constitucionalidade após Constituição de 1988, será feito um aprofundamento nas modalidades de controle de constitucionalidade concentrado e controle difuso, bem como serão analisados aspectos de controle preventivo e repressivo que são exercidos pelos Poderes Executivo e Legislativo, e por fim, apontar a notável expansão e evolução do Controle do Difuso, bem como refletir com sua adequação com o Novo Código de Processo Civil, com base na Teoria dos Precedentes Judiciais tornando nesses aspectos mais próximo do controle concentrado de constitucionalidade no tange a eficácias das decisões. PALAVRAS-CHAVE: Controle de constitucionalidade; Novo Código de Processo Civil; Controle Difuso; Controle Concentrado; Controle preventivo e repressivo.
E POR FALAR EM JUSTIÇA: O QUE É FAZER A COISA CERTA?
Authors: DE LIMA SANDRA MARA MACIEL , DOS SANTOS DALLEGRAVE CAROLINE ALESSANDRA TABORDA , BONSERE SILVANA FÁTIMA MEZAROBA
Published: April 2020

O presente estudo busca analisar as abordagens de justiça de Michael Sandel em sua obra denominada “Justiça – O que é fazer a coisa certa” e, por meio desta análise, identificar quais as contribuições metodológicas e epistemológicas da obra para o campo jurídico e às demais ciências sociais, bem como identificar as principais limitações encontradas no tema central – justiça - segundo as concepções apresentadas. Adotou-se a metodologia da pesquisa bibliográfica, com ênfase completa para a obra objeto deste estudo. Como resultado desta análise, que perpassa pelo tema da justiça sobre as abordagens da maximização de bem-estar, respeito à liberdade e promoção da virtude, concluiu-se que o autor posiciona-se favoravelmente à última concepção – justiça como virtude – e utilizou-se do método de pesquisa dialética e com tendência epistemológica dialógica, por intermédio da reflexão sobre questões de cunho social, que servem de argumento para as concepções de justiça, moral e política não apenas no campo do conhecimento jurídico, mas também nas áreas das ciências sociais. Identificou-se, também, que as abordagens de justiça na obra de Sandel merecem um olhar atendo aos direitos e liberdades individuais; e, ainda, carecem de um estudo mais profundo acerca dos fundamentos que compõem a ética sob a perspectiva de ciência da moral. Palavras-chave: justiça; Filosofia; metodologia; política; bem comum.
O DIREITO COMUNITÁRIO, A UNIÃO EUROPEIA E A IMPORTÂNCIA DAS AÇÕES AFIRMATIVAS ANTE A GLOBALIZAÇÃO.
Authors: BIZAWU KIWONGUI , DE SÉLLOS-KNOERR VIVIANE CÔELHO , JOSÉ VIRGINIA MARIA CURY
Published: April 2020

O presente artigo tem como objetivo principal o estudo doutrinário sobre a União Europeia, dentro do Direito Comunitário, e a importância das ações afirmativas. Para tanto será traçada uma breve evolução histórica da União Europeia, bem como breves considerações sobre o Direito Comunitário, bem como a ligação com ações afirmativas. Ademais, os Tratados que criaram a União Europeia, formam o objeto do Direito Comunitário. O Direito Comunitário é um Direito de Integração, aperfeiçoado, evoluído. Após a Segunda Guerra Mundial, houve a necessidade de unir os Países da Europa (União Europeia), devido às crises financeiras e às atrocidades de Adolf Hitler que desrespeitou, em muito, os Direitos Humanos. No começo da década de cinquenta, iniciaram-se os Tratados para que a União Europeia existisse e acabasse com o abalo à paz mundial. A metodologia utilizada nesta pesquisa foi a do método dedutivo; quanto aos meios a pesquisa foi a bibliográfica, com uso da doutrina e legislação. Palavras-chave: União Europeia; Ações Afirmativas; Globalização; Direito Comunitário.
A EFICÁCIA HORIZONTAL DOS DIREITOS FUNDAMENTAIS NOS CONTRATOS DE DIREITO PRIVADO
Authors: Freitas Lorena De Melo , Da Costa Ilton Garcia , Lucaski Fernando Cesar Vellozo
Published: April 2020

O presente artigo tem como objetivo analisar as teorias que tratam da eficácia horizontal dos direitos fundamentais nas relações privadas e sua aplicação no direito brasileiro. Ao longo do trabalho serão exploradas posições doutrinárias pertinentes ao tema, o fenômeno da constitucionalização do direito civil e os princípios aplicáveis aos contratos, para a partir de então analisar a forma como os direitos fundamentais são interpretados nas relações entre particulares. Palavras-Chave: Direitos fundamentais. Eficácia horizontal. Relações privadas.
AS CONTRATAÇÕES EMPRESARIAIS: UMA VISÃO ACERCA DOS MECANISMOS IMPULSIONADORES À EFETIVAÇÃO DA DIGNIDADE HUMANA E PROMOÇÃO DA RESPONSABILIDADE SOCIAL
Authors: Basto Lupi André Lipp Pinto , Bonsere Silvana Fátima Mezaroba
Published: April 2020

O presente estudo busca compreender quais os mecanismos impulsionadores de due diligence nas contratações empresariais no Brasil, vislumbrando se tocam aspectos da dignidade da pessoa humana e da promoção da responsabilidade social empresarial. Adotou-se a metodologia de pesquisa bibliográfica, com uma investigação histórica acerca do tema proposto, publicações no mercado nacional e internacional, bem como a pesquisa documental acerca de recentes julgados envolvendo o processo de diligência prévia no Brasil. Como resultado do presente estudo, que perpassa por uma definição teórica e origem histórica da due diligence, pela relevância deste processo nas contratações empresariais com vistas à efetivação da dignidade da pessoa humana e promoção da responsabilidade social empresarial, e finalmente especifica os mecanismos nacionais que impulsionam esta análise diligente, concluiu-se que o Brasil possui mecanismos eficazes para a concreta realização de um processo de due diligence, com vistas à efetivação da dignidade humana e promoção da responsabilidade social, e basta o Estado naquilo que lhe cabe, e o particular em cada contratação, exigir dos stakeholders a adoção desta postura de análise mínima destes mecanismos. As contribuições trazidas conferem maior visibilidade a estes instrumentos de fácil acesso de consulta por qualquer cidadão, empresa e poder público, que a propósito, concorrem para efetivação da dignidade humana e promoção da responsabilidade social empresarial. Palavras-chave: Due diligence; dignidade humana; responsabilidade social; trabalho escravo; contratos.
Temporal Associations of Daily Changes in Sleep and Depression Core Symptoms in Patients Suffering From Major Depressive Disorder: Idiographic Time-Series Analysis
Authors: Lorenz Noah , Sander Christian , Ivanova Galina , Hegerl Ulrich
Published: April 2020

Background

There is a strong link between sleep and major depression; however, the causal relationship remains unclear. In particular, it is unknown whether changes in depression core symptoms precede or follow changes in sleep, and whether a longer or shorter sleep duration is related to improvements of depression core symptoms.

Objective

The aim of this study was to investigate temporal associations between sleep and depression in patients suffering from major depressive disorder using an idiographic research approach.

Methods

Time-series data of daily sleep assessments (time in bed and total sleep time) and self-rated depression core symptoms for an average of 173 days per patient were analyzed in 22 patients diagnosed with recurrent major depressive disorder using a vector autoregression model. Granger causality tests were conducted to test for possible causality. Impulse response analysis and forecast error variance decomposition were performed to quantify the temporal mutual impact of sleep and depression.

Results

Overall, 11 positive and 5 negative associations were identified between time in bed/total sleep time and depression core symptoms. Granger analysis showed that time in bed/total sleep time caused depression core symptoms in 9 associations, whereas this temporal order was reversed for the other 7 associations. Most of the variance (10%) concerning depression core symptoms could be explained by time in bed. Changes in sleep or depressive symptoms of 1 SD had the greatest impact on the other variable in the following 2 to 4 days.

Conclusions

Longer rather than shorter bedtimes were associated with more depression core symptoms. However, the temporal orders of the associations were heterogeneous.
Age-Related Differences in the Evaluation of a Virtual Health Agent’s Appearance and Embodiment in a Health-Related Interaction: Experimental Lab Study (Preprint)
Authors: Straßmann Carolin , Krämer Nicole C , Buschmeier Hendrik , Kopp Stefan
Published: April 2020

BACKGROUND

Assistive technologies have become more important owing to the aging population, especially when they foster healthy behaviors. Because of their natural interface, virtual agents are promising assistants for people in need of support. To engage people during an interaction with these technologies, such assistants need to match the users´ needs and preferences, especially with regard to social outcomes.

OBJECTIVE

Prior research has already determined the importance of an agent’s appearance in a human-agent interaction. As seniors can particularly benefit from the use of virtual agents to maintain their autonomy, it is important to investigate their special needs. However, there are almost no studies focusing on age-related differences with regard to appearance effects.

METHODS

A 2×4 between-subjects design was used to investigate the age-related differences of appearance effects in a human-agent interaction. In this study, 46 seniors and 84 students interacted in a health scenario with a virtual agent, whose appearance varied (cartoon-stylized humanoid agent, cartoon-stylized machine-like agent, more realistic humanoid agent, and nonembodied agent [voice only]). After the interaction, participants reported on the evaluation of the agent, usage intention, perceived presence of the agent, bonding toward the agent, and overall evaluation of the interaction.

RESULTS

The findings suggested that seniors evaluated the agent more positively (liked the agent more and evaluated it as more realistic, attractive, and sociable) and showed more bonding toward the agent regardless of the appearance than did students. In addition, interaction effects were found. Seniors reported the highest usage intention for the cartoon-stylized humanoid agent, whereas students reported the lowest usage intention for this agent. The same pattern was found for participant bonding with the agent. Seniors showed more bonding when interacting with the cartoon-stylized humanoid agent or voice only agent, whereas students showed the least bonding when interacting with the cartoon-stylized humanoid agent.

CONCLUSIONS

In health-related interactions, target group–related differences exist with regard to a virtual assistant’s appearance. When elderly individuals are the target group, a humanoid virtual assistant might trigger specific social responses and be evaluated more positively at least in short-term interactions.
Using a Clinical Workflow Analysis to Enhance eHealth Implementation Planning: Tutorial and Case Study (Preprint)
Authors: Staras Stephanie , Tauscher Justin S , Rich Natalie , Samarah Esaa , Thompson Lindsay A , Vinson Michelle M , Muszynski Michael J , Shenkman Elizabeth A
Published: April 2020

UNSTRUCTURED

eHealth apps often fail to improve clinical outcomes due to poor integration with clinical workflow—the sequence and personnel needed to undertake a series of tasks for clinical care. Our central thesis is that eHealth interventions will be more effective if the clinical workflow is studied and taken into consideration for intervention implementation. This paper aims to provide an introductory tutorial on when and how to use a clinical workflow analysis to guide the implementation of eHealth interventions. The tutorial includes a step-by-step guide to conducting a clinical workflow analysis in planning for eHealth implementation. We began with a description of why a clinical workflow analysis is best completed before the implementation of eHealth interventions. Next, we described 4 steps needed to perform the clinical workflow analysis: the identification of discrete workflow components, workflow assessment, triangulation, and the stakeholder proposal of intervention implementation. Finally, we presented a case study of a clinical workflow analysis, which was conducted during patient visits of patients aged 11 or 12 years from 4 diverse pediatric or family medicine clinics to plan the implementation of a tablet-based app for adolescent vaccination. Investigators planning the implementation of new eHealth interventions in health care settings can use the presented steps to assess clinical workflow, thereby maximizing the match of their intervention with the clinical workflow. Conducting a prospective workflow study allows for evidence-based planning, identifying potential pitfalls, and increasing stakeholder buy-in and engagement. This tutorial should aid investigators in increasing the successful implementation of eHealth interventions.
COVID-19 pneumonia diagnosis using a simple 2D deep learning framework with a single chest CT image (Preprint)
Authors: Lee Jinseok
Published: April 2020

BACKGROUND

The coronavirus disease (COVID-19) has explosively spread worldwide since the beginning of 2020. According to a multinational consensus statement from the Fleischner Society, computed tomography (CT) can be used as a relevant screening tool owing to its higher sensitivity for detecting early pneumonic changes. However, physicians are extremely busy fighting COVID-19 in this era of worldwide crisis. Thus, it is crucial to accelerate the development of an artificial intelligence (AI) diagnostic tool to support physicians.

OBJECTIVE

We aimed to quickly develop an AI technique to diagnose COVID-19 pneumonia and differentiate it from non-COVID pneumonia and non-pneumonia diseases on CT.

METHODS

A simple 2D deep learning framework, named fast-track COVID-19 classification network (FCONet), was developed to diagnose COVID-19 pneumonia based on a single chest CT image. FCONet was developed by transfer learning, using one of the four state-of-art pre-trained deep learning models (VGG16, ResNet50, InceptionV3, or Xception) as a backbone. For training and testing of FCONet, we collected 3,993 chest CT images of patients with COVID-19 pneumonia, other pneumonia, and non-pneumonia diseases from Wonkwang University Hospital, Chonnam National University Hospital, and the Italian Society of Medical and Interventional Radiology public database. These CT images were split into a training and a testing set at a ratio of 8:2. For the test dataset, the diagnostic performance to diagnose COVID-19 pneumonia was compared among the four pre-trained FCONet models. In addition, we tested the FCONet models on an additional external testing dataset extracted from the embedded low-quality chest CT images of COVID-19 pneumonia in recently published papers.

RESULTS

Of the four pre-trained models of FCONet, the ResNet50 showed excellent diagnostic performance (sensitivity 99.58%, specificity 100%, and accuracy 99.87%) and outperformed the other three pre-trained models in testing dataset. In additional external test dataset using low-quality CT images, the detection accuracy of the ResNet50 model was the highest (96.97%), followed by Xception, InceptionV3, and VGG16 (90.71%, 89.38%, and 87.12%, respectively).

CONCLUSIONS

The FCONet, a simple 2D deep learning framework based on a single chest CT image, provides excellent diagnostic performance in detecting COVID-19 pneumonia. Based on our testing dataset, the ResNet50-based FCONet might be the best model, as it outperformed other FCONet models based on VGG16, Xception, and InceptionV3.
User Perceptions of Virtual Hospital Apps in China: Systematic Search (Preprint)
Authors: Wang Yuan , Liu Yuqiao , Shi Yancui , Yu Yanjun , Yang Jucheng
Published: April 2020

BACKGROUND

Virtual hospital apps are mobile apps that offer functionalities of online consultation, medical guidance, health community forums, referrals, outpatient appointments or virtual hospital-to-home care services. With an increasing number of online medical and health care consulting services, virtual hospital apps have made health care more accessible and fairer for all, especially in China. However, they have occurred without control or regulation. User evaluation can provide directions to help apps optimize identification, lower risks, and guarantee service quality.

OBJECTIVE

We aimed to conduct a systematic search for virtual hospital apps in China. To get a global view, virtual hospital apps were assessed and characterized by means of quantitative analysis. To get a local view, we conducted a content feedback analysis to explore user requirements, expectations, and preferences.

METHODS

A search was conducted of the most popular Apple and Android app stores in China. We characterized and verified virtual hospital apps and grouped apps according to quantification analysis. We then crawled apps and paid attention to corresponding reviews to incorporate users’ involvement, and then performed aspect-based content labeling and analysis using an inductive approach.

RESULTS

A total of 239 apps were identified in the virtual hospital app markets in China, and 2686 informative corresponding reviews were analyzed. The evidence showed that usefulness and ease of use were vital facts for engagement. Users were likely to trust a consulting service with a high number of downloads. Furthermore, users expected frequently used apps with more optimization to improve virtual service. We characterized apps according to 4 key features: (1) app functionalities, including online doctor consultation, in-app purchases, tailored education, and community forums; (2) security and privacy, including user data management and user privacy; (3) health management, including health tracking, reminders, and notifications; and (4) technical aspects, including user interface and equipment connection.

CONCLUSIONS

Virtual hospitals relying on the mobile internet are growing rapidly. A large number of virtual hospital apps are available and accessible to a growing number of people. Evidence from this systematic search can help various types of virtual hospital models enhance virtual health care experiences, go beyond offline hospitals, and continuously meet the needs of individual end users.
Adherence of Female Health Care Workers to the Use a Web-Based Tool for Improving and Modifying Lifestyle: Prospective Target Group Pilot Study (Preprint)
Authors: Jukic Tomislav , Ihan Alojz , Petek Šter Marija , Strojnik Vojko , Stubljar David , Starc Andrej
Published: April 2020

BACKGROUND

Health care professionals are exposed to the psychological and physiological effects of stress, which is a well-known risk factor for various mental and physical health problems.

OBJECTIVE

The aims of this study were to assess the adherence of female health care workers to use a web-based tool for improving and modifying lifestyle and to identify the potential factors influencing their adherence.

METHODS

A prospective, observational study was performed. A total of 80 female health care workers (physicians and gradated nurses) from 2 university medical centers and female members of a family medicine society participated. Participants completed a questionnaire that inquired about their basic demographic data and physical fitness. Physical fitness was assessed by the Rockport Fitness Walking Test. Adherence to a web-based application (24@life) was followed for 3 months and the number of log-ins into the application was counted.

RESULTS

The study was conducted from March to October 2019. Significantly high workload has been detected in all groups (P<.05), except in the general practitioner with normal workload group. The graduated nurse working in the surgery room group showed chronic stress with elevated S-cortisol levels (>690 nmol/L); activated cellular immune system with elevated concentrations of lymphocytes (reference 1.1-2.5 × 109 cells/L), CD3 cells (reference 0.7-1.9 × 109 cells/L), CD8 cells (reference 0.2-0.7 × 109 cells/L), and HLA-DR/CD3 cells (reference 0.04-0.2 × 109 cells/L); and the worst quality of sleep (mean 2.8 [SD 1.2]). Only 32 of 80 participants (40%) were adherent to the web-based application. Participants most frequently viewed web pages on areas of physical activity (497 times) and nutrition (332 times). No factors or participant’s characteristics such as weight (odds ratio [OR] 1.026, 95% CI 0.977-1.078), BMI (OR 0.993, 95% CI 0.834-1.184), age (OR 0.970, 95% CI 0.910-1.034), or stress level (OR 0.997, 95% CI 0.995-1.000) were identified to affect the adherence rates.

CONCLUSIONS

Female health care workers exposed to high workload did not find the web-based application useful for improving and modifying their lifestyle. Therefore, other strategies that might help health care workers facing stress and improve their lifestyle should be identified.
Development of an Index for the Inspection of Aedes aegypti Breeding Sites in Brazil: Multi-criteria Analysis (Preprint)
Authors: Lima Yuri , Pinheiro Wallace , Barbosa Carlos Eduardo , Magalhães Matheus , Chaves Miriam , de Souza Jano Moreira , Rodrigues Sérgio , Xexéo Geraldo
Published: April 2020

BACKGROUND

Aedes aegypti is a vector for the transmission of diseases such as dengue fever, chikungunya, Zika fever, and yellow fever. In 2016, over 1 million cases of these diseases were reported in Brazil, which is an alarming public health issue. One of the ways of controlling this disease is by inspecting and neutralizing the places where A. aegypti lays its eggs. The Ministry of Planning, Development, and Administration of Brazil maintains the inspection statistics.

OBJECTIVE

We propose a multi-criteria analysis to create an index for A. aegypti inspections reported through the Ministry of Planning, Development, and Administration system of Brazil.

METHODS

Based on the repository from urban cleaning services combined with data on inspections conducted by government agencies in several Brazilian cities and municipalities, we selected and combined metrics, which we further ranked using the analytic hierarchy process methodology. We also developed risk maps based on the analytic hierarchy process ranking of the A. aegypti breeding sites.

RESULTS

Based on our analysis and the available data, the priority for inspections should consider the number of sick people (weight 0.350), medical evaluations (weight 0.239), inspections (weight 0.201), mosquito breeding sites (weight 0.126), and days of absence from work (weight 0.096).

CONCLUSIONS

The proposed index could aid public health practitioners in preventing the appearance of new A. aegypti breeding sites. This information technology application can help solve such public health challenges.
Orphan drug development and epilepsy with Ana Mingorance
Authors: Mingorance Anna
Published: April 2020

Learn more from Ana Mingorance of the Loulou Foundation about the current status of drug development in epilepsy. In this Expert Perspective, Ana describes how the landscape of this field has changed, with new developments in technology as well as challenges associated with the regulatory approval of new drugs leading to a shift in focus to developing novel drugs to treat orphan epilepsy indications.
IMAGING OF THE MUSCULOSKELETAL SYSTEM
Authors: Editorial Artiсle
Published: April 2020

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Seroprevalencia y factores asociados a la infección por Leptospira spp. En población de Moniquirá, Boyacá
Authors: Monroy Angela Liliana , González Alejandra Del Pilar , González Angie Lorenna , Perez Dora Catterine , Arias Leidy Lorena , López Diana Paola
Published: April 2020

Introducción: La leptospirosis es una enfermedad zoonótica, producida por la bacteria Leptospira spp; afecta a seres humanos con un cuadro sintomático inespecífico o cursa de forma subclínica, siendo frecuente en zonas tropicales y de ambientes húmedos. Objetivo: Determinar la prevalencia y factores asociados a anticuerpos anti – Leptospira spp en población asintomática de Moniquirá, Boyacá.Materiales y métodos: Estudio analítico de corte trasversal, se tomó una muestra de 193 participantes procedentes del municipio, previo consentimiento informado, se aplicó un instrumento de recolección de datos que indagaba factores sociodemográficos y epidemiológicos, además se determinaron anticuerpos tipo IgM para Leptospira spp, se analizó la información mediante frecuencias absolutas, relativas, y se determinó la asociación con un Odds Ratio (OR) evaluando significancia con p <0.05. Resultados: Se encontró una seropositividad para anticuerpos anti – Leptospira spp de 4.7 %, (9/193 IC95% 1.71-7.69), siendo la población con mayor prevalencia expendedores de carne, además se observa una tendencia a mayor prevalencia de la infección en el sexo masculino (OR 1.43 IC 95% 0.35-7.22), entre los menores de 45 años (OR 2.66 IC 95% 0.64 -13.2) y procedencia de zona rural (OR 1.33 IC 95% 0.32- 5.73). Conclusión: Se identificaron personas asintomáticas con infección por Leptospira, lo cual aporta datos relevantes al departamento de Boyacá en cuanto a la endemia de esta patología y la vigilancia desde la salud pública que se sugiere seguir en población con mayor frecuencia de infección, como los expendedores de carne.
Endoftalmitis endógena como primera manifestación de meningitis por Haemophilus influenza: reporte de un caso
Authors: Pérez M Alba , Pérez-Galvez Daniel , Quijano N Bernardo , Peñaloza R Manuela , Montaña L Jaime A.
Published: April 2020

La endoftalmitis endógena es responsable del 2-15 % de las endoftalmitis, se relaciona con una infección sistémica hasta en un 52-90% de los casos, en elcontexto de infecciones sistémicas como abscesos hepáticos, neumonia, infecciones de vias urinarias, meningitis, usurios de drogas endovenosas y fungémias. Haemophilus influenzae es un agente etiológico inusual de esta patología, hay pocos casos reportados a nivel mundial y no se han reportado casos en nuestro país; las endoftalmitis por Haemophilus se caractererizan por tener un pronóstico visual sombrio, ya que pueden presentar complicaciones severas y comprometer permanentemente la visión.A continuación, se describe un caso de endoftalmitis endogéna como primera manifestación de meningitis asociada a H. Influenzae en una paciente inmunocompetente y sin factores de riesgo.
Enumerations of bargraphs with respect to corner statistics
Authors: Mansour Toufik , Yıldırım Gökhan
Published: April 2020

We study the enumeration of bargraphs with respect to some corner statistics. We find generating functions for the number of bargraphs that track the corner statistics of interest, the number of cells, and the number of columns. We also consider bargraph representation of set partitions and obtain some explicit formulas for the number of specific types of corners in such representations.
Neoadjuvant chemotherapy followed by interval debulking surgery versus primary debulking surgery in the advanced epithelial ovarian cancer- a retrospective cohort study
Authors: Maricic Slobodan , Mandic Aljosa , Dejanovic Ninoslav , Kladar Nebojsa , Popovic Marina , Ivkovic-Kapicl Tatjana , Gutic Bojana , Kokanov Dunja
Published: April 2020

Background/Aim. The gold standard in treating the advanced ovarian cancer (AOC) is primary debulking surgery (PDS) followed by platinum-based adjuvant chemotherapy. In the AOC, the extent of tumor resection (residual tumor volume) is the most important prognostic factor for overall survival (OS) and progression-free survival (PFS). Neoadjuvant chemotherapy (NACT) followed by interval debulking surgery (IDS) is an experimental treatment of the AOC, introduced in clinical practice in order to improve cytoreduction rate and prolong survival. The aim of this study was to compare the survival and cytoreduction rate of NACT+IDS and PDS in patients with the AOC. Methods. This retrospective cohort study included patients with the AOC, separated into two groups. The first group treated with PDS had 59 patients, while the second group, treated with NACT + IDS, had 33 patients. Results. A lower rate of suboptimal cytoreduction (39.39%) was found in the NACT + IDS group than in the PDS group (57.63%). The percentage of complete cytoreduction was higher in patients treated with NACT + IDS (51.52%) than in those treated with PDS (38.98%). Nevertheless, median OS and PFS were not significantly different between the groups (p < 0.05). OS was 35 months and 31 months in the PDS and NACT + IDS groups, respectively. PFS was 16 months in the PDS and 19 months in the NACT + IDS group. Conclusion. Despite the higher rate of optimal debulking surgery after NACT+ IDS, survival of patients treated with method was not better than those treated with PDS. The decision for either NACT+IDS or PDS should be tailored to the individual patient.
CBCT analysis of bone density in bicortical defects after augmentation with alloplastic and xenogeneic bone substitutes: A study on domestic pigs
Authors: Djordjevic Filip , Mihailovic Branko , Mladenovic Rasa , Dubovina Dejan , Kostic Mirjana , Stanisic Jelena , Vlahovic Zoran
Published: April 2020

Background/Aim. A significant benefit in bicortical defects healing can be achieved by guided tissue and guided bone regeneration. The aim of this study was a cone-beam computed tomography (CBCT) radiographic bone density analysis of bicortical defects healing when treated with guided bone regeneration and two bone substitutes ? bovine xenograft and alloplastic bone substitute. Methods. The research was performed on domestic pigs in two phases. In the first phase, extraction of all teeth in the intercanine sector was performed in the lower jaw and postextraction wounds were sutured. In the second phase, after the period required for healing, bicortical defects were formed ? following the elevation of mucoperiosteal flaps from the vestibular and lingual side in the area of the previously extracted teeth, surgical removal of the cambium layer of periosteum was performed in the area of future defects with sharp surgical scissors and curette. Two defects, 10 mm in diameter, on the left and right side of the medial line were formed and filled with alloplastic bone substitute on the left and xenograft on the right side afterward. After augmentation, the defects were covered by a collagen resorptive membrane on both sides, and the flap was repositioned and sutured. After 12 weeks, experimental animals were sacrificed. The surrounding native bone was used as a control. Results. Analysis of bone tissue density showed a statistically significant difference between the examined bone substitutes (p < 0.01), with a better effect achieved by the use of alloplastic bone substitute. After applying Bonferroni correction, the difference was still statistically significant. Conclusion. Both bone substitutes used in the study showed good osteoconductive properties in the treatment of bicortical defects. Bone tissue density in defects filled with alloplastic bone graft was statistically significantly higher than that in the defects filled with xenograft.
Unexpected Consequences: The Effects on Non-Accelerated Filers of an Accelerated Filing Deadline and SOX Section 404
Authors: Dong Bei , Tate Stefanie L. , Xu Le Emily
Published: April 2020

SYNOPSIS

Regulations implemented by the SEC in 2003 and 2004 simultaneously shortened the financial statement filing deadlines and increased the time required for both the preparation of financial statements and the related audit of accelerated filers (AFs). However, there were indirect, unintended negative consequences for companies not subject to the regulations, namely, non-accelerated filers (NAFs). The new regulations imposed strains on auditor resources requiring auditors to make resource allocation decisions that negatively affected NAFs. We find that NAFs with an auditor who had a high proportion of AF clients (high-AF) had longer audit delays after the regulations were implemented than NAFs of an auditor with a low proportion of AF clients (low-AF). Further, we document that NAFs with high-AF auditors were more likely to change auditors than NAFs with low-AF auditors. Finally, NAFs that switched to auditors with less AFs experienced shorter audit delays after the auditor change.

JEL Classifications: M42; M48.
Do High Ability Managers Mitigate Litigation Related to Financial Reporting?
Authors: Krishnan Gopal V. , Wang Changjiang , Yu Wei
Published: April 2020

We provide empirical evidence that incremental to the commonly used industry-based proxy for litigation risk and firm-level attributes, managerial ability in transforming corporate resources into revenues is associated with lower risk of litigation arising from financial reporting. The negative relation between managerial ability and litigation risk does not seem to stem from more frequent disclosure of bad news. Instead, our results suggest that high ability managers are less likely to engage in opportunistic financial reporting, i.e., lower financial statement errors and abnormal revenues. The contribution of our study is to explicitly offer a managerial human capital perspective in explaining variations in litigation risk related to financial reporting.

Data Availability: Data are available from the public sources cited in the text.

JEL Classifications: G24; G28.
An Empirical Investigation of Beyond Budgeting Practices
Authors: Matějka Michal , Merchant Kenneth A. , O'Grady Winnie
Published: April 2020

Our study compares management control practices in 80 organizations that have implemented Beyond Budgeting to a group of 121 organizations that have not. First, we find that BB organizations tend to use (1) high levels of decentralization, (2) flexible resource allocations without fixed timelines, (3) relative target setting, and (4) weak individual incentives. Second, we find evidence suggesting that many BB implementers find it difficult to reduce the reliance on a fixed annual budget for decision making and on financial performance measures for performance evaluation. Third, we find that the likelihood and scope of BB implementation is negatively associated with the importance of long-term investment coordination. Finally, we examine whether combinations of various management control practices affect the likelihood of BB implementation, management control effectiveness, or control system gaming but find only weak interaction effects and associations among practices.
Seniority Orders between Inside Debts and External Debts
Authors: Deng Mingcherng , Nan Lin , Wen Xiaoyan
Published: April 2020

In this paper, we study the seniority orders between a firm's external debts and its inside-debt compensation to its manager and analyze how different seniority orders influence the equilibrium inside debt and external debt. We find that the equilibrium inside debt varies with different seniority orders and is contingent on the firm's financial constraints. We also analyze how the liquidation value upon bankruptcy affects the equilibrium external debt given different seniority orders, and we show that the external debt may increase in the liquidation value. In addition, we examine an extension with asset diversion. We find that contrary to conventional wisdom, assigning seniority to the manager's inside-debt compensation does not mitigate the manager's asset diversion. In fact, asset diversion is more severe when the manager's inside-debt compensation has seniority over the external debts.
Oikema, de Claude-Nicolas Ledoux: arquitetura para libertinos?
Authors: Bueno Guilherme
Published: April 2020

This paper focus on the Oikema – project for a House of Pleasures, a public brothel designed by French architect Claude-Nicolas Ledoux (published by him in 1804). Topics as architecture mediating public life and privacy; architecture and aesthetic experience; architecture and gender; architecture and hetertopy are the guidelines for its discussion.
Fóruns Híbridos de Participação: no sentido de melhores práticas para a construção da cidade
Authors: Machado-Martins Maíra , Maya-Monteiro Patricia
Published: April 2020

This article presents the results of a Project process held in the under-spaces of two viaducts in the Laranjeiras district in the city of Rio de Janeiro. This process is part of a community-university partnership project, the “Square, the Street and the District”, which has been developed by students and professors of different fields and courses. This project aims to emphasize the relevance of interventions in the cities are made by a direct mode of popular participation, both in the elaboration and in the implementation of landscape architecture and urban proposals. A collaborative process was shaped to embody the notion that there is a “local knowledge, which is nurtured by the daily life”, as Milton Santos (1997, p.7) argues. Here, we narrate the methodological construction and the process of design experience in this case at the Laranjeiras.district. With this, we expect to demonstrate how the design and building of the city can be developed thorough participative and collaborative processes. The existence of an assembled and well informed project can be an environment to foster discussion so that more just and appropriate solutions may get forge.
Oficina sobre Território: um estudo sobre os Areais de Itaguaí
Authors: Carneiro Beatriz
Published: April 2020

This article aims to document the workshop sobre território that happened in 2018 as an initiative by the group of student who organized the ninth edition of the Architecture Week of PUC-Rio and young Brazilian architects. The main purpose of the study was to understand and propose interventions in the area of Itaguaí’s Dunes, where sand mining exploration for civil construction in Rio de Janeiro take place.
Temporary transvenous cardiac pacing: a survey on current practice
Authors: Diemberger Igor , Massaro Giulia , Rossillo Antonio , Chieffo Enrico , Dugo Daniela , Guarracini Fabrizio , Pellegrino Pier Luigi , Perna Francesco , Landolina Maurizio , De Ponti Roberto , Berisso Massimo Zoni , Ricci Renato Pietro , Boriani Giuseppe
Published: April 2020

Background

Temporary transvenous cardiac pacing (TTCP) is a standard procedure in current practice, despite limited coverage in consensus guidelines. However, many authors reported several complications associated with TTCP, especially development of infections of cardiac implantable electronic devices (CIED). The aim of this survey was to provide a country-wide picture of current practice regarding TTCP.

Methods

Data were collected using an online survey that was administered to members of the Italian Association of Arrhythmology and Cardiac Pacing.

Results

We collected data from 102 physicians, working in 81 Italian hospitals from 17/21 regions. Our data evidenced that different strategies are adopted in case of acute bradycardia with a tendency to limit TTCP mainly to advanced atrioventricular block. However, some centers reported a greater use in elective procedures. TTCP is usually performed by electrophysiologists or interventional cardiologists and, differently from previous reports, mainly by a femoral approach and with nonfloating catheters. We found high inhomogeneity regarding prevention of infections and thromboembolic complications and in post-TTCP management, associated with different TTCP volumes and a strategy for management of acute bradyarrhythmias.

Conclusion

This survey evidenced a high inhomogeneity in the approaches adopted by Italian cardiologists for TTCP. Further studies are needed to explore if these divergences are associated with different long-term outcomes, especially incidence of CIED-related infections.
Theoretical Study of the Electronic Properties of X2YZ (X = Fe, Co; Y = Zr, Mo; Z = Ge, Sb) Ternary Heusler: Abinitio Study
Authors: Maafa A. , Rozale H. , Oughilas A. , Boubaça A. , Amar A. , Lucache D.
Published: April 2020

In the purpose of exploring new Heusler alloys with different magnetic applications, we have employed first principles calculations method within density functional theory. After checking the structural stability of X2YZ Heusler alloys (X = Fe, Co; Y =Zr, Mo and Z = Ge, Sb), we found that Cu2MnAl type structure is more favorable for most compounds except for X2MoGe and Co2MoSb, were the Hg2CuTi structure is energetically more stable. The trends in magnetic and electronic structures can be predicted by the structure types as well as the different kinds of hybridizations between the constituents. Among the two series only two compounds were identified to be true half metals with potential applications in spintronic devices. While one compound was classified as a nonmagnetic semiconductor with a small band gap. For the rest of materials, we found that the metallic behavior is dominant. These materials show possible interesting features in technical applications as well. The effect of distortion on the magnetic properties of Co2ZrGe and Fe2ZrSb showed that the half metallic character was preserved within a moderate range of volume changes, which makes it possible to grow these materials as thin films with modern techniques.
Kappa-Slender Modules
Authors: Dimitric Radoslav
Published: April 2020

For an arbitrary infinite cardinal κ, we define classes of κ-cslender and κ-tslender modules as well as related classes of κ-hmodules and initiate a study of these classes.
A new parameterized logarithmic kernel function for linear optimization with a double barrier term yielding the best known iteration bound
Authors: Ayache Benhadid , Khaled Saoudi
Published: April 2020

In this paper, we propose a large-update primal-dual interior point algorithm for linear optimization. The method is based on a new class of kernel functions which differs from the existing kernel functions in which it has a double barrier term. The investigation according to it yields the best known iteration bound O

n

log
(
n
)
log

(

n
∈

)

\sqrt n \log (n)\log \left( {{n \over \in }} \right)

for large-update algorithm with the special choice of its parameter m and thus improves the iteration bound obtained in Bai et al. [2] for large-update algorithm.
Polynomials and degrees of maps in real normed algebras
Authors: Sakkalis Takis
Published: April 2020

Let 𝒜 be the algebra of quaternions ℍ or octonions 𝕆. In this manuscript an elementary proof is given, based on ideas of Cauchy and D’Alembert, of the fact that an ordinary polynomial f(t) ∈ 𝒜[t] has a root in 𝒜. As a consequence, the Jacobian determinant |J(f)| is always nonnegative in 𝒜. Moreover, using the idea of the topological degree we show that a regular polynomial g(t) over 𝒜 has also a root in 𝒜. Finally, utilizing multiplication (*) in 𝒜, we prove various results on the topological degree of products of maps. In particular, if S is the unit sphere in 𝒜 and h
1, h
2 : S → S are smooth maps, it is shown that deg(h
1 * h
2) = deg(h
1) + deg(h
2).
Modulação dos efeitos citotóxicos e mutagênicos do paracetamol pelo suco de caju e cajuína em meristemas de raízes de allium cepa
Authors: Santos Francisca Ires da Silva , Silva Renata Kelly dos Santos e , Farias Marlene Gomes de , Carvalho David de Sousa , Corrêa Layde de Sousa , Sousa Athanara Alves de , Nobre Taline Alves , Lima Paloma Alves Ferreira , Pereira Ana Rafaela Silva , Coêlho Maria do Perpetuo Socorro de Sousa , Nascimento Glauto Tuquarre Melo , Oliveira Victor Alves de , Silva Felipe Cavalcanti Carneiro da , Sousa João Marcelo de Castro e , Cavalcante Ana Amelia de Carvalho Melo
Published: April 2020

Objetivo: Avaliar a capacidade moduladora do suco de caju e cajuína diante dos efeitos toxicogenéticos do paracetamol, utilizando o sistema teste vegetal Allium cepa. Métodos: Grupos de tratamentos: Controle Negativo (água destilada - AD); Grupo 2 (10 ml de suco de caju + 30 ml AD), Grupo 3 (10 ml de cajuína + 30 ml AD); Grupo 4 (10 ml de suco de caju + 30 ml de CP); Grupo 5 (10 ml de cajuína diluído com 30 ml de CP); e Controle Positivo (40ml de paracetamol 0,3mg/ml - CP). Utilizados cinco bulbos por tratamento, enraizadas, e transferida para suas respectivas soluções. As radículas foram coletadas e fixadas em ácido acético (3:1) após os tempos de 24 e 48 horas de exposição. As lâminas foram coradas com orceína acética a 2%. Resultados: Sugere-se que compostos bioativos estejam presentes no suco de caju e sua derivação cajuína, possuindo capacidade de inibir a formação de alterações mutagênicas, causadas pelo fármaco utilizado durante o estudo, a partir da observação do aumento do Índice Mitótico e redução das Alterações Cromossômicas. Conclusão: Os dados encontrados mostraram que o suco de caju e cajuína modularam os efeitos toxicogenéticos do paracetamol, interferindo na mutagênese induzida pelo fármaco.
The Effect of Internal Corporate Social Responsibility on Job Satisfaction: An Empirical Study on Jordanian Pharmaceutical Companies
Authors: Altheeb Sura , Al-Louzi Kholoud Sudqi
Published: April 2020

The current research investigates the impact of internal corporate social responsibility on job satisfaction in Jordanian pharmaceutical companies. Quantitative research design and regression analysis were applied on a total of 302 valid returns that were obtained in a questionnaire based survey from 14 pharmaceutical companies among employees, supervisors and managers. The results showed that internal corporate social responsibility was significantly related to job satisfaction and three of its dimensions, namely working conditions, work life balance and empowerment contributed significantly to job satisfaction, whereas employment stability and skills development had no contribution. This study implies that Jordanian pharmaceutical companies have to try their best to promote and facilitate internal corporate social responsibility among their employees in an effort to improve their job satisfaction, which will eventually yield positive results for the company as a whole. In light of these results, the research presented many recommendations for future research; the most important ones were the application of this study in other sectors, cultures, and countries, and using of multi method for collecting data.
Al muqaranah Al Adabiyah Baina Imru Al Qais wa Lord Alfred Tennysson
Authors: Tidjani Ridwan Adewale
Published: April 2020

Abstract

Imru-l-qais remains an idol in the ancient Arabic poem. He had transformed it by introducing some new metaphor and rhetoric, which Arabian poets stayed on for decades after. Also, Imru-l-qais poem has been able to move outside Arabian peninsula into other international literature. This paper focused on one of his greatest poem (Almuhalaqoh) and how influencial this work was received by poets in their different literature - English, French, Dutch, and Russian. Alfred Lord Tennyson's _Locksley_ _Hall_ (1892) was was inspired by Imru-l-qais' poem. He read it, diggest it, and reproduce it in English form. However, this paper uses the comparative method to review the influential aspect between the two works. Therefore, the paper sought to reveal the confluences of the two poems substantively, which the result of the comparision showed that they dealt almost with the same subject within the poem; as well as meeting up on the structure and rhythm level. Historically, the connection between the two poems emerged through the translation of some Arabic Poems and its explanation by William Jones (1794), Johann Wolfgang von Goethe (1832) and others.