bluuebunny/crossref_metadata_2025 huggingface dataset:
A Perspective of PI3K/AKT/mTOR Pathway Inhibitors to Overcome Drug-resistance in Breast Cancer Therapy
Authors: Mandal Sudip Kumar , Samanta Samir Kumar
Published: August 2024

The heterogeneous disease, breast cancer (BC), is a frequently detected cancer
today, including hormone receptor-positive (HR+), human epidermal growth factor
receptor-2-positive (HER2+), and triple-negative (ER-, PR-, HER2-) BC. Advanced endocrine
therapies could improve about 85% HR+ BC patient survival. Still, 20% - 30%
of cases of endocrine therapy resistance are observed. For all kinds of breast cancer,
drug resistance is a common and dangerous phenomenon, comprised of two types: de novo
resistance and acquired resistance (prolonged exposure). According to recent works
of literature, the PI3K/AKT/mTOR pathway has become an emerging target for overcoming
drug resistance in BC therapy due to its close association with tumour growth
and resistance from current therapies. Activation of the PI3K/AKT/mTOR pathway was
found to promote multidrug resistance by elevating drugs’ outflow. The first orally active
PI3K inhibitor, Alpelisib (BYL-719) in fulvestrant combination, was approved for
treating HR+/ HER2− metastatic BC. Therefore, utilizing PI3K/mTOR/AKT inhibitors
in combination with currently available strategies could be an optimistic approach to
overcoming drug resistance and resensitizing drug-resistant tumor cells of BC. Here, in
this perspective, BC cancer therapies related to drug resistance, the involvement of
PI3K/AKT/mTOR pathway in drug resistance and multi-drug resistance, and the role of
PI3K/AKT/mTOR inhibitors in getting rid of drug resistance have been illuminated.
Network Pharmacology, Molecular Docking Analysis and Experiment Validations on Molecular Targets and Mechanisms of the Dispel-Scar
Ointment in Scar Treatment
Authors: Li Zhaoyi , Cao Yi , Li Hui , Le Sihua , Yin Libo
Published: August 2024

Background:

Dispel-Scar Ointment is used in Traditional Chinese Medicine to treat
scarred tissue and increasing evidence has shown that DSO is a potent therapeutic; however, its
exact mechanism remains unexplored.

Aim of the Study:

This study explored the molecular mechanisms of action of DSO in scarring
using network pharmacology, molecular docking, and experimental validation.

Materials and Methods:

Public databases were applied to predict the bioactive ingredients and
putative targets of DSO against scars. A compounds-targets network was constructed using the
Cytoscape software. Molecular docking was performed to verify the correlation between the
major positive ingredients and hub targets, visualised using PyMol 2.3. Enrichment analysis was
implemented using ClueGo and FunRich to specify the biological capabilities and related pathways
of hub targets. SwissADME software was used to predict the ADME capabilities of the
protein-related active compounds between DSO and scar in order to analyse the absorption and
permeation across cell membranes of DSO. We assessed the skin sensitizer potential of the bioactive
compounds of DSO using Pred-Skin computational tool. Experimental validations were
conducted to elucidate the influence of DSO on keloid fibroblast cells using the CCK-8, woundscratch,
cell reactive oxygen species, and western blot assays.

Results:

Network pharmacological analysis of DSO for scar treatment identified 146 ingredients
and 1078 gene targets. Major targets included prostaglandin-endoperoxide synthase 2 matrix
metallopeptidases and nitric oxide synthase 2. Molecular docking showed MMP2-flavoxanthin,
MMP9-luteolin and MMP-9-kaempferol bound best to DSO. ClueGo analysis revealed 29
pathways (p<0.05) and FunRich 345 pathways (p<0.05), mainly toll-like receptor, TGF-β, interleukin-
4/13, glypican, and tumour necrosis factor-related apoptosis-inducing ligand pathways.
The results valued by the SwissADME and PreADMET tools illustrated that 12 compounds in
DSO were almost permeable through the skin. Pred-Skin computational tool represented that
these 12 bioactive compounds reflected skin sensitizer potential. Experimental analysis revealed
that DSO could restrain the proliferation and migration of scar fibroblasts and facilitate their
apoptosis in a concentration-dependent manner. DSO also decreased TGF-β1, -βR2, pSMAD2,
pSMAD3, SMAD4, CoL1a1, and MMP2 expression.

Conclusion:

Network pharmacology, molecular docking, and experimental validation showed
DSO's feasibility in scar therapy. It may restrain scars through the TGF-β1/SMADs/MMPs signalling
pathway, providing a basis for DSO's scar treatment application.
An Assessment of the Degradation Potential and Genomic Insights Towards Hydroxylated Biphenyls by Rhodococcus opacus Strain KT112-7
Authors: Egorova Darya , Olsson Bjorn , Kir'yanova Tatyana , Plotnikova Elena
Published: August 2024

Background:

Hydroxylated biphenyls are currently recognized as secondary pollutants
that are hazardous to animals and humans. Bacterial degradation is the most effective method for
the degradation of hydroxylated biphenyls. Several strains capable of degrading polychlorinated
biphenyls have been described, which also degrade hydroxylated biphenyls.

Objectives:

1) To study the biodegradative properties of the Rhodococcus opacus strain KT112-7
towards mono-hydroxylated biphenyls. 2) To analyze the genome of the Rhodococcus opacus
strain KT112-7. 3) To identify the genetic basis for the unique biodegradative potential of the Rhodococcus
opacus strain KT112-7.

Methods:

A genome analysis of the strain KT112-7 was conducted based on whole-genome sequencing
using various programs and databases (Velvet, CONTIGuator, RAST, KEGG) for annotation
and identification of protein-coding sequences. The strain KT112-7 was cultivated in a K1
mineral medium supplemented with mono-hydroxy biphenyls or mono-hydroxybenzoic acids as
the carbon source. For the growth test mono-hydroxybiphenyls or mono-hydroxybenzoic acids
were dosed at concentrations of 0.5 g/L and 1.0 g/L correspondently, and the bacterial growth was
monitored by the optical density. For the biodegradative activity test, mono-hydroxybiphenyls
were dosed at a concentration of 0.1 g/L in vials, inoculated with late exponential phase bacteria
previously acclimated on biphenyl. Compound analysis was performed using GC-MS, HPLC, and
spectrophotometry.

Results:

It was found that the genome of strain KT112-7 consists of a chromosome and 2 plasmids.
Biphenyl degradation genes (bph genes) were identified on plasmid PRHWK1 and the chromosome,
as well as hydroxybenzoic acid degradation genes on the chromosome. The strain
KT112-7 was shown to degrade mono-hydroxylated biphenyls to basal metabolic compounds of
the cell, with the highest destructive activity observed towards 3- and 4-hydroxylated biphenyls
(98%).

Conclusion:

The Rhodococcus opacus strain KT112-7 is characterized by genetic systems that
contribute to its high biodegradative potential towards mono-hydroxylated biphenyls and their
metabolites. Thus, the strain KT112-7 is promising for use in hydroxybiphenyl degradation technologies.
Biological Potential of Oxoglaucine in Medicine for the Treatment of Human Disorders: An Update on Pharmacological Activities and Related Molecular Mechanism
Authors: Patel Kanika , Patel Dinesh Kumar
Published: August 2024

Medicinal plants are an integral part of the medical system in many countries
around the world. Natural products have been used as important biological sources for drug
discovery over the past half-century. Alkaloids are a group of natural compounds that contain
a basic nitrogen atom. Oxoglaucine is a phytochemical of the oxoaporphines class
phytochemical isolated from Aquilegia ecalcarata Maxim, Corydalis yanhusuo, Chasmanthera
dependens, and Xylopia aethiopica. The purpose of this study is to analyze all
the scientific information about oxoglaucine in order to know the health-beneficial potential
of oxoglaucine in medicine. The detailed pharmacological activities of oxoglaucine are
analyzed and discussed in this review. The scientific data of the present review about oxoglaucine
were collected from PubMed, Scopus, Science Direct, and Google using the terms
oxoglaucine, oxoaporphines, alkaloid, phytochemical, pharmacological, and herbal medicine.
The scientific findings of the present review article describe the biological importance
and therapeutic effectiveness of oxoglaucine in medicine. The present article's
scientific data signified the biological potential of oxoglaucine against inflammatory diseases,
arthritis, osteoarthritis, immune response, enterovirus, and poliovirus. Furthermore,
its anticancer, antiaggregation, antifungal, antiprotozoal, and cytotoxic potential are also
described in this review article. The scientific information in this article will be helpful to
all the scientific peoples of biological science to understand the therapeutic potential of
oxoglaucine in medicine.
UTILIZATION OF TUBIFEX WORMS AS NATURAL FEED FOR GROWTH AND DEVELOPMENT OF FISH LARVAE
Authors:   Universitas Jenderal Soedirman, Simangunsong Tohap , Anjaini Jefri ,   Universitas Jenderal Soedirman, Soedibya Petrus Hary Tjahja ,   Universitas Jenderal Soedirman, Liu Chun-Hung ,   Pingtung University of Science and Technology Taiwan
Published: August 2024

Fish farming has become essential in meeting the global demand for animal protein, with the maintenance of fish larvae being a crucial stage in determining production success. Tubifex worms, rich in essential nutrients, have long been used as natural feed in aquaculture. This article provides a comprehensive review of the utilization of Tubifex worms, covering their morphological and anatomical characteristics, habitat, and nutritional content. The benefits of using Tubifex worms as natural feed include enhanced growth and health of fish larvae and cost efficiency in production. This article also outlines feeding procedures, risk management, and challenges in the mass production of Tubifex worms. Additionally, recent research and practical approaches that can be implemented to optimize the use of Tubifex worms in fish farming are discussed, providing guidance for fish farmers and researchers in aquaculture.
Current Status of Barriers to mHealth Access Among Patients With Stroke and Steps Toward the Digital Health Era: Systematic Review
Authors: Niyomyart Atsadaporn , Ruksakulpiwat Suebsarn , Benjasirisan Chitchanok , Phianhasin Lalipat , Nigussie Kabtamu , Thorngthip Sutthinee , Shamita Gazi , Thampakkul Jai , Begashaw Lidya
Published: August 2024

Background

Mobile health (mHealth) offers significant benefits for patients with stroke, facilitating remote monitoring and personalized health care solutions beyond traditional settings. However, there is a dearth of comprehensive data, particularly qualitative insights, on the barriers to mHealth access. Understanding these barriers is crucial for devising strategies to enhance mHealth use among patients with stroke.

Objective

This study aims to examine the recent literature focusing on barriers to mHealth access among patients with stroke.

Methods

A systematic search of PubMed, MEDLINE, Web of Science, and CINAHL Plus Full Text was conducted for literature published between 2017 and 2023. Abstracts and full texts were independently screened based on predetermined inclusion and exclusion criteria. Data synthesis was performed using the convergent integrated analysis framework recommended by the Joanna Briggs Institute.

Results

A total of 12 studies met the inclusion criteria. The majority were qualitative studies (about 42%), followed by mixed methods (25%), pilot studies (about 17%), nonrandomized controlled trials (about 8%), and observational studies (about 8%). Participants included patients with stroke, caregivers, and various health care professionals. The most common mHealth practices were home-based telerehabilitation (30%) and poststroke mHealth and telecare services (20%). Identified barriers were categorized into two primary themes: (1) at the patient level and (2) at the health provider-patient-device interaction level. The first theme includes 2 subthemes: health-related issues and patient acceptability. The second theme encompassed 3 subthemes: infrastructure challenges (including software, networking, and hardware), support system deficiencies, and time constraints.

Conclusions

This systematic review underscores significant barriers to mHealth adoption among patients with stroke. Addressing these barriers in future research is imperative to ensure that mHealth solutions effectively meet patients’ needs.
Formulation and Physical Evaluation of Hand Sanitizer Gel with Various Concentration Ambon Banana Peel Extract (Musa paradisiaca var. sapientum (L))
Authors: Nastiti Ginanjar Putri , Rahmayanti Mayu , Febrian Rezky Dimas
Published: August 2024

Hand washing is an activity that can reduce microorganism contamination, but some people whose work environment is far from hand washing facilities will experience difficulties. This gave rise to the innovation of practical hand washing without water, commonly called a hand sanitizer. Currently, the innovation of materials for making hand sanitizers uses natural ingredients, one of which can be Ambon banana peels, where the use of banana peels can also increase their economic value. The purpose of this study was to evaluate the physical preparation of hand sanitizer gel from Ambon banana peel extract at various concentrations. This study used Ambon banana peels extracted by the UAE method. Next, three hand sanitizer gel formulations were made with the active ingredient, a dry extract of Ambon banana peel. Formulation 1 (F1) uses 7% extract, Formulation 2 (F2) uses 10% extract, and Formulation 3 (F3) uses 13% extract. Each formulation was subjected to physical evaluation, including organoleptic tests, homogeneity, pH, spreadability, and adhesion, for three replications. The results showed that the three formulations had almost the same organoleptic visuals, namely a brown color, a soft texture, and the typical smell of Ambon bananas. Each formulation also fulfills the requirement of being homogeneous, and the pH is within the pH range of the skin. Spreadability and adhesion to the three formulas also meet the requirements for topical preparations. It can be concluded that the three formulations of Ambon banana peel hand sanitizer gel fulfill the requirements as topical preparations based on their physical evaluation. The three formulas did not show significant differences, so the concentration of the active ingredients in this study had no significant effect on the physical state of the preparations
Perancangan dan Pembuatan Vessel dengan Double Cylinder pada Unit Electric Road Sweeper
Authors: Ikhsan Ridha , Sugiyanto Sugiyanto , Ismail Andhi Akhmad , Kuncoroadi Robertus Tirta
Published: August 2024

Electric road sweeper yang dikembangkan Departemen Teknik Mesin Sekolah Vokasi Universitas Gadjah Mada dapat menangani permasalahan pada pengelolaan sampah. Untuk meningkatkan kinerja sweeper masih memerlukan beberapa perubahan pada unit tersebut terutama pada bagian vessel sweeper. Dalam upaya meningkatkan kinerja sweper dibutuhkan perancangan vessel. Perancangan dan analisis kinerja dari vessel menggunakan software Autodesk Inventor. Pada penelitian ini dilakukan penambahan dan penggantian tipe silinder hidrolik untuk menjadikannya kendaraan angkut. Selain itu, penggunaan material yang lebih ringan juga mengurangi bobot vessel dari 650 kg menjadi 278,95 kg. Hasil simulasi menunjukkan semua komponen vessel sweeper memiliki safety factor di atas satu, menandakan aman dalam penggunaannya. Selain itu, desain ini mampu menahan beban hingga 4900 N tanpa melebihi batas yield strength material yang digunakan vessel. Kemiringan maksimum vessel sweeper adalah 30,4 derajat. Pengujian silinder hidrolik menunjukkan kecepatan extend 11,77 m/s dan retract 7,9 m/s. Dalam kondisi beban 100 kg, kecepatan extend menjadi 12,49 m/s dan retract menjadi 8,39 m/s, pergerakan retract lebih cepat karena gaya gravitasi.
Analisis Resiko Fuel System Terhadap Kasus Low Power Engine Performance pada Unit Asphalt Finisher di PT. PP Presisi
Authors: Widada Reza Ananda , Prihadianto Braam Delfian , Wibowo Setyawan Bekti , Harjono Harjono
Published: August 2024

Sistem bahan bakar (fuel system) sangat berperan penting pada unit Asphalt Finisher BOMAG BF 800 C yang beroperasi di pekerjaan pengaspalan jalan. Performa engine dari unit Asphalt Finisher BOMAG BF 800 C akan menurun apabila tidak dilakukan pemeriksaan pada sistem bahan bakar dengan segera. Tujuan dari penelitian ini adalah menganalisis sistem bahan bakar (fuel system) yang menjadi penyebab terjadinya low power engine performance pada unit Asphalt Finisher BOMAG BF 800 C. Metode yang digunakan untuk menyelesaikan permasalahan tersebut adalah metode kualitatif dengan menggunakan analisis Fault Tree Analysis (FTA) dan Failure Mode and Effect Analysis (FMEA) serta metode kuantitatif dengan menghitung mean time to failure (MTTF) dan mean time to repair (MTTR) sesuai dengan rekam jejak penggunaan dan perbaikan unit Asphalt Finisher BOMAG BF 800 C. Berdasarkan hasil penelitian yang telah dilakukan, dinyatakan bahwa nilai RPN injektor bahan bakar adalah 324 dan filter bahan bakar adalah 168. Penghitungan tersebut yang membuat komponen-komponen tersebut menjadi komponen terkritis dalam kasus low power engine performance. Interval kegiatan perawatan yang ditentukan pada injektor bahan bakar adalah 84 jam dan filter bahan bakar adalah 35 jam.
Rancang Bangun Sistem Peringatan Pendeteksi Halangan Gerak Swing Pada Swing Area Berbasis Arduino Uno dengan Sensor Ultrasonik Untuk Excavator
Authors: Anyuca Herbudi Bagas , Ismail Andhi Akhmad
Published: August 2024

Kesehatan dan keselamatan kerja terutama dalam proyek alat berat merupakan suatu hal yang sangat penting untuk menghindari terjadinya kecelakaan kerja. Dalam bidang konstruksi dan pertambangan kecelakaan kerja yang banyak dialami biasanya seperti tergilas, serta terhantam. Kasus kecelakaan tersebut kebanyakan disebabkan oleh faktor kelalain operator atau manusia, dan juga faktor dari mesin atau alat. Pada hidrolik excavator terdapat gerakan swing, gerakan tersebut berpotensi menyebabkan kecelakaan kerja seperti menghantam objek pada swing area dikarenakan objek tersebut berada dalam blind spots yang tidak bisa terukur dan terlihat oleh operator. Pada penelitian ini, penulis merancang suatu alat yang berfungsi sebagai sistem peringatan dan monitoring pendeteksi halangan gerak swing pada swing area untuk menghindari terjadinya kecelakaan kerja, sekaligus menguji kinerja sistem yang telah dibuat. Perancangan alat ini menggunakan sensor ultrasonik HC SR-04 yang mampu mendeteksi suatu objek dengan gelombang ultrasonik, LCD 1602 sebagai alat monitor berapa jarak antara sensor dengan objek yang menghalangi gerak swing, serta dengan tambahan buzzer sebagai sistem peringatan yang akan berbunyi pada jarak tertentu. Dengan demikian operator dapat mengantisipasi apabila terdapat objek yang menghalangi dalam gerak swing. Hasil pengujian keseluruhan dari sistem yang telah dibuat menunjukkan bahwa bagian depan didapatkan tingkat keberhasilan pengujian sebanyak 84% dengan standar deviasi atau simpangan baku sebesar 0,3116, dan bagian belakang didapatkan tingkat keberhasilan pengujian sebanyak 86% dengan standar deviasi atau simpangan baku sebesar 0,2916.
The Role of the Left Middle Temporal Gyrus in the Semantic Processing of Nouns and Verbs in Chinese: A Transcranial Direct Current Stimulation Study
Authors: Zhang Huilin
Published: August 2024

Vocabulary processing is an important cognitive function of human beings. Nouns and verbs are core word classes that support languages, and the differences in neural mechanisms of semantic processing between the two word classes have received a lot of attention. An important language processing area, left middle temporal gyrus (LMTG), has attracted a lot of attention because of its significant role in language processing. However, there is controversy about the role of LMTG in the semantic processing of nouns and verbs, and few related studies were based on Chinese, an ideological language. With the aid of transcranial direct current stimulation (tDCS), the current study investigated the role of LMTG in the semantic processing of Chinese nouns and verbs. Results showed that after receiving anodal-tDCS stimulation over LMTG, participants’ semantic processing performance of Chinese verbs was significantly promoted. At the same time, such changes were not observed in the noun and number processing. Meanwhile, compared with concrete verbs, participants’ semantic processing performance of abstract verbs was improved more. We concluded that LMTG played an important role in the semantic processing of Chinese verbs, especially abstract verbs.
The Function of Artificial Intelligence in Inclusive English Language Teaching: Strategies for Diverse Learners
Authors: Kannadhasan M.
Published: August 2024

Artificial Intelligence (AI) has emerged as a transformative technology with significant potential in addressing learner diversity within the realm of English Language Teaching (ELT). AI technologies, such as natural language processing, machine learning, and adaptive learning systems, can be harnessed to personalize instruction and support diverse learners. AI-powered adaptive learning systems can provide learners with varied learning paths, allowing them to progress at their own pace and focus on areas of strength and weakness. It can assist teachers in identifying areas of need and providing targeted support, freeing up instructors to focus on more complex tasks and fostering a more inclusive learning environment. The paper investigates the potential applications of artificial intelligence (AI) to enhance inclusiveness in English language training (ELT). It examines the methods and ramifications of integrating AI tools into ELT courses to improve inclusion and address student diversity. This study offers helpful advice to educators on how to design inclusive learning environments that satisfy the diverse requirements of language learners by investigating learner-centred methodologies, AI technology, and theoretical foundations. The findings demonstrate the revolutionary potential of AI in fostering personalized learning, accessibility, and diverse learning environments, all of which contribute to the advancement of inclusive ELT pedagogy.
Girl in Translation: The Transnational Mother as Martyr
Authors: Uma S. , Nagalakshmi M.
Published: August 2024

Over recent decades, representations of motherhood in U.S. popular culture have proliferated, influenced by media coverage, literature, and advocacy. This paper examines the intersection of literature and social science through an analysis of Jean Kwok's novel Girl in Translation (2010), focusing on the character 'Ma' and her experiences as a transnational mother. The narrative portrays Ma's journey alongside her daughter Kimberly from Hong Kong to Brooklyn, navigating cultural dislocation, economic hardship, and language barriers. Through Ma's perspective, the novel illuminates the complexities faced by immigrant mothers striving to provide better opportunities for their children while grappling with identity shifts and societal marginalization. This study integrates insights from literary analysis and social science to explore broader themes of gender, power dynamics, and the immigrant experience, shedding light on the transformative impact of cultural adaptation and resilience in the face of adversity.
Cartografías de nuestras realidades
Authors: Romero Laura , Céspedes Arce Carolina , Sánchez Alvarado Yolanda , Popoca Gómez César Antonio , del Rivero Herrera Antonio , Miranda Pérez Luis Adrián , Cariño Huerta Gloria Laura , Cortés Fernández Orly Casandra , Eguiluz Paola , Sánchez Meneses Iliana , Benhumea Nayeli , Vargas Mendoza Laura , Rosas Fuentes Gonzalo Rodrigo , Flecha Macías Xitlally Guadalupe , Baxin Martínez Jesús Israel , Zavala Núñez Andrea , Matías Rendón Ana , Caballero Borja Edith , Soberanes Benítez Said Antonio , Orduña Silverio
Published: August 2024

La cartografía nos permite contar con diversas coordenadas para abordar la realidad, pues para transformarla es necesario entenderla. También sirve para ampliar la mirada o para desenfocarla, y así identificar la relación entre lo material y lo inmaterial, lo experimentado y lo imaginado, con el fin de propiciar la reflexión acerca de sus posibilidades pedagógicas y de investigación social. Además de intentar explicar la realidad vivida, procura proyectarnos más allá de las fronteras trazadas en nuestros mapas, con lo que cobra valores catafóricos, al adelantar lo que podrá venir.
THE IMPACT OF BROKEN HOME FAMILIES ON THE MORAL AND PSYCHIC DEVELOPMENT OF GRADE VI ELEMENTARY SCHOOL STUDENTS
Authors: Wulandari Nyimas , Wantini Wantini , Diponegoro Ahmad Muhammad
Published: August 2024

The results of the teacher's daily research show that children from broken home families often make noise during class hours, this is because the child seeks attention to others. This then prompted the author to conduct a study that focused on broken home children with the aim of conducting a case study which then examined more deeply the impact of broken home families on the moral and psychic development of grade VI elementary school students at SD N 1 Sribitan. By using quality research with a case study approach. Participants in this study the author chose based on backgrounds and behaviors that stood out while in school using purposive samples so that two students were found who stood out from five students who had the same background, namely class VI SDN 1 Sribitan, namely A.C.P and .P.D.A. The results obtained from this study are an illustration that the influence or impact of broken home families is very real in terms of children's moral and psychic development. In this study, it can be explained that the bad moral problems that participants often do are not wanting to apologize if they are wrong, making noise, and not obeying the rules that have been applied in schools.
Cómo se escribió Namuy misag: las investigaciones de Gregorio Hernández de Alba, John Howland Rowe y Francisco Tumiñá Pillimué en Guambía, Colombia, 1946-1949
Authors: Rappaport Joanne
Published: August 2024

El archivo de Gregorio Hernández de Alba contiene un extenso cuerpo de información etnográfica sobre la comunidad indígena de Guambía que revela que el etnólogo, más que investigador de terreno, fue gestor de los estudios de otros. Entre ellos, se destaca el trabajo del antropólogo norteamericano John Howland Rowe en compañía de su informante indígena, Francisco Tumiñá Pillimué. El artículo explora cómo el conocimiento y las investigaciones hechas por Tumiñá contribuyeron a la riqueza de este repositorio etnográfico y cómo Hernández de Alba recurrió a esta información para elaborar el libro Nuestra gente (Namuy misag). Arguye que Tumiñá debe ser considerado, no como una víctima de la apropiación etnológica por agentes externos, sino como un creador de conocimiento.
Historias del Darién. La ciudad colonial
Authors: Sarcina Alberto , Quintero Carolina , Vignolo Paolo
Published: August 2024

Historias del Darién es un proyecto editorial que busca la difusión del trabajo y las actividades que se han realizado en torno al Museo y el Parque Arqueológico de Santa María de la Antigua del Darién: de las investigaciones científicas, pero también de las experiencias, memorias y conocimientos de los habitantes de la región del Darién. En la colección, el Darién se cuenta desde múltiples voces y perspectivas, a partir de estrategias comunitarias de reconstrucción histórica y arqueológica. “La ciudad colonial”, primera publicación de esta serie, acompaña la primera parte del recorrido del parque en donde se cuentan algunos aspectos sobre la primera ciudad fundada durante la conquista española en tierra continental americana.
NANOPARTÍCULAS POLIMÉRICAS PARA ENTREGA DE FÁRMACOS AO CÉREBRO POR ADMINISTRAÇÃO INTRANASAL: UMA BREVE REVISÃO
Authors: Alves Brayner Pereira Kaique , R.E. Mansur Cláudia , Barbosa Jurgilas Patrícia
Published: August 2024

A barreira hematoencefálica (BHE) é um grande desafio biológico para o direcionamento de fármacos ao cérebro pela via sistêmica, o que diminui a eficiência terapêutica de inúmeros fármacos. Nesse contexto, a via nasal pode ser utilizada para perpassar a BHE pelos nervos olfatório e trigêmio presentes na cavidade nasal, porém, ainda assim, apresenta limitações, principalmente, relacionadas a degradação do fármaco no ambiente da mucosa nasal e o efeito de depuração. Dessa forma, nanopartículas têm sido utilizadas para contornar essas limitações e tornar a administração de fármacos através do nariz mais eficiente. Dentre as nanopartículas existentes, as nanopartículas poliméricas oferecem algumas vantagens devido a sua liberação controlada e a sua superfície passível de funcionalização para favorecer o direcionamento. Diante do exposto, esse trabalho buscou fazer um levantamento das principais características das nanopartículas poliméricas possíveis para o direcionamento intranasal, os principais polímeros utilizados, assim como algumas das moléculas e biomoléculas utilizadas como agentes de funcionalização.
La facultad vivida: archivo fotográfico del programa de medicina de la Universidad Tecnológica de Pereira. 1977-2023
Authors: Cabrales Vega Rodolfo Adrián , Moreno Gómez Germán Alberto , Franco Londoño Jairo , Trujillo Henao Samuel Eduardo
Published: August 2024

Este libro es uno de los productos esperados del proyecto “Imaginarios sobre la creación y desarrollo de la Facultad de Medicina de la Universidad Tecnológica de Pereira”. 2020- 2021. Sus autores son miembros de la Red de conocimiento Pensamiento y Prospectiva PENPRO, dedicada a la reflexión y reconstrucción del pasado de la facultad, como un paso necesario para la discusión del presente y la planeación del futuro de la educación médica en la ciudad de Pereira. Este libro completa un ciclo que inició con el rescate de los documentos oficiales, que fueron publicados en el libro La Facultad Vivida – Archivo Documental Ciencias de la Salud 1977-2017 en el año 2019. Las fotografías aquí presentadas son el resultado de un proceso que incluyó la recolección, organización, selección, análisis y presentación de un corpus inicial de más de mil imágenes, obtenidas de distintas fuentes, a lo largo de los últimos cuatro años. Cada capítulo recopila un grupo específico de imágenes de docentes, estudiantes, administrativos que transitaron esos espacios que también fueron cambiando con el tiempo. A la subjetividad del autor o donante, que decidió congelar en una fotografía ese momento único e irrepetible y a su decisión de enviarnos esa y no otra imagen, se agrega el referente personal de los autores, su nivel de formación, sus conocimientos y su intento, quizá vano, de convertir en memoria lo que antes fue un instante de vida.
Reliability and agreement of root length measurements during orthodontic treatment in images from different CBCT machines using multiplanar reconstruction
Authors: Johansson Kristina , Paulsson Liselotte , Christell Helena
Published: August 2024

Objectives: To assess inter- and intrarater reliability and agreement for measurements of root lengths using multiplanar reconstruction (MPR) in cone beam computed tomography (CBCT) examinations.
Furthermore, to determine whether using MPR from different CBCT machines was a reliable and reproducible method for assessment of root length during orthodontic treatment of adolescents. 
Materials and methods: A total of 40 CBCT examinations obtained before, during and after orthodontic treatment of 14 adolescents, with fixed appliances from a multicentre randomised controlled trial, were used. All roots from the incisors to the first molars were measured by two independent raters and in accordance with a protocol preceded by a multi-step calibration. Reliability was assessed by intra class correlation (ICC). Agreement was assessed by measurement error according to the Dahlberg formula and Bland–Altman plot.
Results: The number of repeated measurements varied from 436 to 474 for the different timepoints. Good to excellent inter- and intrarater reliability for different tooth groups and timepoints were shown. Measurement error for inter- and intrarater agreement varied between 0.41 mm and 0.77 mm. The Bland–Altman plot with 95% limits of agreement varied between +1.43 mm and −2.01 mm for different tooth groups and timepoints. 
Conclusions: The results of this study indicate that CBCT using MPR from different machines is a reproducible method for measuring root length during different phases of orthodontic treatment. When interpreting root shortening measurements in CBCT using MPR for clinical or research purposes, values below 2 mm should be approached with caution, as they may contain measurement errors.
Abordajes éticos en cuidados paliativos: Una revisión de las estrategias y desafíos del personal médico
Authors:   Universidad Iberoamericana del Ecuador, Ecuador., Escobar Bautista Abrahan Rodrigo , Gabela Acurio Edison Santiago ,   Investigador Independiente
Published: August 2024

Los cuidados paliativos presentan desafíos para el personal médico. Esta revisión exploró las estrategias y retos éticos en este contexto. Se realizó una búsqueda sistemática en bases de datos, seleccionando estudios que abordarán la perspectiva ética del personal médico en cuidados paliativos. Se encontró que las principales estrategias fueron el enfoque centrado en el paciente, la comunicación abierta, la toma de decisiones compartida y el apoyo emocional. Los desafíos incluyeron la falta de formación en ética, dificultades de comunicación, gestión de conflictos y barreras institucionales. Factores como valores personales y contexto cultural influyeron en las decisiones éticas. Se concluyó que se requiere promover la formación en ética, un enfoque multidisciplinario y políticas institucionales para abordar los retos. Futuras investigaciones deben profundizar en intervenciones para apoyar al personal médico en la toma de decisiones éticas en cuidados paliativos.
Oversettelser av utdanningspolitikk i midlertidige nettverksorganisasjoner – et systemteoretisk perspektiv
Authors: Hansen Petteri , Sivesind Kirsten
Published: August 2024

In this chapter, which is partly based on our previous research articles, we examine how translations of education policy take place in temporary network organizations. We apply a sociological systems theory perspective and start with a general introduction to Niklas Luhmann’s systems theory. Emphasis is placed on organizations as a form of social system that, through communication, processes various systemic expectations. We then focus on organizational cooperation and the role of temporary network organizations in the preparation and implementation of political programs in a Nordic context. By introducing two discourse analytical strategies (an analysis of couplings and semantic analysis) and presenting two empirical cases, our article discusses the possibilities and limits of translations between political ideas, scientific knowledge and educational practice.
”Nu är det väl bara att skriva ihop det hela”. Om rapporteringen av forskningsstudier
Authors: Magnússon Gunnlaugur
Published: August 2024

While much of this anthology explores different approaches to education research that focus on policy texts (different types of texts are discussed and various ways of analyzing policy texts have been presented), this chapter focuses on how such studies should be reported, that is to say, whether a report is shaped as an essay, dissertation, article, or book chapter. The research report will also be discussed as both a product (i.e., something to be created and handled by others) and a process (i.e., an activity that takes place over time). The different parts of a report, its content and function will be discussed, as well as how a report author can underline and highlight a study’s strengths and inform about its weaknesses. The latter is of particular importance for the study’s validity and reliability or credibility and trustworthiness. The chapter also contains sections with a particular focus on the function and use of theories as well as on research ethics.
Karakterisasi Kopi Unggulan Indonesia Jenis Arabika Sangrai Medium To Dark Menggunakan Fourier Transform Infra Red
Authors: Mafazi Nurul , Jalil Zulkarnain , Yusibani Elin
Published: August 2024

This research was conducted to determine the chemical characteristics of Arabica Indonesia's coffee beans. Four types of coffee beans are taken as samples, i.e., from Toraja, Wamena, Kintamani, and Flores, then roasted to the medium to dark level around temperatures (213-215)°C within 9-13 minutes. Chemical properties testing in the form of identification of functional groups of coffee beans before and after the roasting process is carried out using FTIR. The results showed that the roasting process affects the functional groups and the appearance of flavor compounds in roasted coffee beans. There is the appearance of ether groups in the 1000-1300 cm-1 spectra region, aromatic acid groups in the 1680-1700 cm-1 spectra region, vinyl and lactone ester groups in the 1762-1780 cm-1 spectra region, 1724-1739 cm-1 aldehyde groups, 1740-1755 cm-1 aliphatic ester groups, 1705-1714 cm-1 aliphatic acid groups, and ketone groups in 1705-1725 cm-1 spectra region. Carbohydrates in the region of 1400-900 cm-1 are seen to have decreased transmittance.
Classification of Roasting Level of Coffee Beans Using Convolutional Neural Network with MobileNet Architecture for Android Implementation
Authors: Pakaya Isran Mohamad , Radi Radi , Purwantana Bambang
Published: August 2024

The roasting process has a significant impact on the aroma profile and taste of coffee making it an essential stage in the coffee processing. Currently, the classification of coffee bean roasting levels still relies on subjective human visual assessment, which can lead to errors due to fatigue or negligence. To overcome this problem, a classification system was developed using computer vision technology with a deep learning approach. The present study designed a coffee bean roasting level classification system based on image analysis integrated within an Android application. The Convolutional Neural Network (CNN) model with the MobileNet architecture was used to identify and classify coffee beans based on their roasting level. Two CNN models, namely CNN Alpha and CNN Beta were used in this study. The dataset included 1.600 coffee bean images, with 1.200 images used to train the model and 400 images used to test the accuracy. In this experiment, the input image had an optimal size of 70x70 pixels, a learning rate of 0.0001, and 100 epochs for both models. The model training and testing results in the highest accuracy of 98-88% in 6.40-0.0012 minutes.The application test results obtained 93.55% accuracy, 97.06% precision, and 96.67% recall. These results indicate that this model and application function optimally in classifying coffee bean roasting levels accurately. Overall, this study reveals the potential of integrating CNN with the MobileNet architecture into an Android-based application to change the way of roasting level classification, as well as to improve efficiency and accuracy. Keywords: Coffee, Roasting, Convolutional Neural Network, MobileNet, Android.
Pengaruh Metode Problem Based Learning Terhadap Hasil Belajar Geografi Kelas XI Di SMAN 3 Tangerang
Authors: Rahma Shadrina Aulia , _ Muzani , _ Samadi
Published: August 2024

Rumusan masalah dalam penelitian ini adalah apakah penggunaan metode pembelajaran Problem Based Learning berpengaruh terhadap hasil belajar geografi siswa pada materi keragaman budaya Indonesia kelas XI di SMAN 3 Tangerang. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh metode pembelajaran Problem Based Learning terhadap hasil belajar geografi siswa pada materi keragaman budaya Indonesia kelas XI di SMAN 3 Tangerang. Jenis penelitian ini adalah penelitian kuantitatif dengan pendekatan eksperimen. Dari hasil penelitian dapat disimpulkan bahwa metode pembelajaran Problem Based Learning memiliki pengaruh terhadap hasil belajar geografi siswa materi keragaman budaya Indonesia kelas XI di SMAN 3 Tangerang. Diperoleh nilai t-hitung 7,299 sedangkan t-tabel 1,670 hal ini berarti t-hitung > t-tabel, maka Ha menyatakan terdapat pengaruh metode pembelajaran Problem Based Learning terhadap hasil belajar geografi siswa pada materi keragaman budaya Indonesia kelas XI di SMAN 3 Tangerang diterima dan Ho yang menyatakan tidak terdapat pengaruh metode pembelajaran Problem Based Learning terhadap hasil belajar siswa pada materi keragaman budaya Indonesia kelas XI di SMAN 3 Tangerang ditolak.
Peranan Lingkungan Sebagai Sumber Pembelajaran Geografi dalam Menumbuhkan Sikap dan Perilaku Keruangan Peserta Didik di SMA Negeri 8 Tasikmalaya
Authors: Mandasari Mardyalita , Nabila Raisya Rifatun , Jannah Zailla Nurul , As'ari Ruli
Published: August 2024

Peranan lingkungan seperti lingkungan sosial, keluarga, dan teman merupakan peranan yang sangat penting bagi peserta didik. Lingkungan mempunyai pengaruh besar terhadap proses pembelajaran geografi peserta didik. Pembelajaran geografi dapat membantu peserta didik dalam meningkatkan pemahaman serta diharapkan dapat menumbuhkan sikap dan perilaku keruangan. Tujuan penelitian ini adalah mendeskripsikan peran lingkungan sosial sebagai  pembentukan sikap dan perilaku  keruangan peserta didik SMA Negeri 8 Tasikmalaya. Penelitian ini menggunakan metode deskriptif-kualitatif, dan dilaksanakan di SMA Negeri 8 Tasikmalaya. Pengumpulan data dilakukan dengan observasi, wawancara, dan dokumentasi. Hasil penelitian menunjukan peran lingkungan sekolah sebagai wadah pendidikan mampu membuat siswa memiliki sikap dan perilaku keruangan karena tersedianya buku sebagai sumber belajar, guru sebagai fasilitator serta teman sebaya sebagai tutor pembelajaran. Sementara itu, lingkungan keluarga dan lingkungan masyarakat kurang mendukung peserta didik untuk membentuk sikap dan perilaku keruangan karena tidak adanya edukasi, pengawasan dan sosialisasi yang dilakukan kepada peserta didik.
Analisis Daya Dukung Potensi Wilayah Untuk Pengembangan Kota Sawahlunto Tahun 2018-2023
Authors: Stefani Vincensia Gita , Nefilinda Nefilinda , Despica Rika
Published: August 2024

Penelitian ini bertujuan untuk menganalisis Daya Dukung Potensi Wilayah untuk Pengembangan Kota Sawahlunto Tahun 2018-2023. Penelitian ini termasuk jenis penelitian Kuantitatif. Populasi yang digunakan pada penelitian tersebut adalah seluruh kecamatan yang ada di Kota Sawahlunto. Sampel penelitian ini adalah total sampling. Teknik Analisa data menggunakan analisis Daya dukung ekonomi, daya dukung lahan, daya dukung pangan serta teknik analisis SWOT metode Kuantitatif. Hasil akhir dari penelitian ini mengungkapkan bahwa: 1) Kondisi Daya Dukung Ekonomi Kota Sawahlunto masih dalam kategori tidak mendukung yang dimana sumber daya ekonomi yang dimiliki sudah tidak mampu mendukung kebutuhan ekonomi penduduk akibat kepadatan penduduk. 2) Kondisi lahan di wilayah Sawahlunto yang dipengaruhi kepadatan penduduk mengakibatkan bertambahnya lahan dan menambah segala fasilitas untuk memenuhi kebutuhan. 3) kondisi pangan selama 5 tahun terakhir di Kota Sawahlunto tergolong sebagai wilayah yang memiliki ketersediaan lebih tinggi dibanding dengan kebutuhan penduduk. 4) Arah pengembangan di wilayah tersebut adalah dengan meningkatkan jumlah lahan karena kondisi di wilayah tersebut masih dalam kategori yang butuh perkembangan.
Struktur, Isi, dan Unsur Kebahasaan Teks Cerita Fantasi Siswa Kelas VII SMP Negeri 30 Padang
Authors: Fitri Hidayatul , Tamsin Andria Catri
Published: August 2024

Tujuan penelitian ini adalah mendeskripsikan struktur, isi, dan unsur kebahasaan teks cerita fantasi siswa kelas VII SMP Negeri 30 Padang. Penelitian ini menggunakan metode kualitatif dengan metode deskriptif. Sumber datanya adalah teks cerita fantasi tertulis untuk siswa kelas VII SMP Negeri 30 Padang. Pengumpulan data dilakukan melalui studi dokumentasi. Teknik validasi data dalam penelitian ini adalah teknik triangulasi (cross check). Data dianalisis berdasarkan aspek struktur, isi, dan unsur kebahasaan teks cerita fantasi. Hasil penelitian menyimpulkan sebagai berikut. Pertama, dari 20 teks cerita fantasi, 18 teks mempunyai struktur orientasi yang tepat, 17 teks memiliki struktur komplikasi yang tepat, 14 teks memiliki struktur resolusi yang tepat, dan 15 teks memiliki struktur coda yang tepat. Kedua, dari segi isi, siswa mampu menuliskan isi teks cerita fantasi dengan benar. Ketiga, dari segi unsur kebahasaan, penggunaan kata ganti secara umum sudah benar. Selanjutnya dalam penggunaan kata sambung penanda urutan waktu dan dialog kalimat langsung masih banyak ditemukan yang kurang tepat, bahkan ada yang tidak menggunakannya.
Korelasi Keterampilan Membaca Pemahaman Teks Laporan Hasil Observasi dan Keterampilan Menulis Teks Laporan Hasil Observasi Siswa Kelas X SMA Negeri 2 Bayang
Authors: Feronika Niken Oktri , Gani Erizal
Published: August 2024

The research aimed to describe the level of reading comprehension skills, describe the level of writing skills, and analyze whether there was a correlation between reading comprehension skills and the skills in writing text reports from observations of class X students at SMA Negeri 2 Bayang. This type of research is quantitative research with descriptive methods. The research sample was taken at 15% using a simple random sampling technique. The instrument of this research is a test, namely an objective test of reading comprehension skills and a performance test of writing skills. There are three research results. First, the reading comprehension skills of the text of the observation report of class X students of SMA Negeri 2 Bayang are more than sufficient, with an average calculation of 67.07. Second, the skill of writing the text of the observation report of the students of class X of SMA Negeri 2 Bayang is at a sufficient qualification with an average calculation of 65.21. Third, a significant correlation exists between reading comprehension skills and observation report text writing skills with r_count>r_tabel, namely 0.976>0.297. H0 is rejected, and H1 is accepted because t_count (29.52) is greater than t_table (1.68). Thus, it can be concluded that reading comprehension skills are positively correlated with skills in writing observation report texts.
Implementasi Penyelenggaraan Pariwisata dalam Peningkatan Pendapatan Asli Daerah (Studi Kasus Kawasan Sawarna Kabupaten Lebak)
Authors: Humaedi Imad , Budiati Ayuning , Yulianti Rina
Published: August 2024

This research aims to find out the success of the implementation of tourism in increasing local revenue, to find out the factors that hinder the implementation of tourism in increasing local revenue, and to find out the efforts that can be made to improve the implementation of tourism in increasing local revenue. This research was conducted on in-depth disclosure, so the qualitative approach was used to analyze the research data; it was related to the phenomenon of the problems studied and researched. Based on the discussion of the results of interviews with informants, it can be concluded that several aspects developed by Van Meter and Van Horn in analyzing research on the Implementation of Tourism Implementation in Increasing Regional Original Revenue (Case Study of Sawarna Area, Lebak Regency) can be seen that the Implementation of Tourism Implementation policies in Increasing Regional Original Revenue in Lebak Regency is not optimal, in its implementation it has not shown satisfactory results so that the purpose of organizing tourism in increasing local revenue cannot be adequately achieved.