bluuebunny/crossref_metadata_2025 huggingface dataset:
IŠSEKIMO SINDROMO IR DEPRESIJOS POŽYMIŲ SĄSAJA SENYVO AMŽIAUS ASMENIMS
Authors: Danilova Jekaterina , Ginevičienė Valentina , Kilaitė Justina , Dadelienė Rūta , Mastavičiūtė Asta , Pranckevičienė Erinija , Ahmetov Ildus I , Alekna Vydmantas
Published: January 2025

Ilgėjanti žmonių gyvenimo trukmė pabrėžia fizinės ir psichinės sveikatos svarbą senatvėje. Geresnis išsekimo sindromo ir depresijos požymių supratimas leistų sveika­tos priežiūros specialistams identifikuoti šių geriatrinių būklių rizikos veiksnius, įgyvendinti prevencines prie­mones, tobulinti intervencijas ir klinikinę praktiką. Šio tyrimo tikslas buvo nustatyti senyvo amžiaus asmenų išsekimo sindromo požymių sąsają su depresijos pasi­reiškimu. Tyrime dalyvavo 58 tiriamieji (nuo 65 iki 95 metų), kurie buvo suskirstyti į dvi grupes: eksperimen­tinę ir kontrolinę. Eksperimentinę grupę (n=33) sudarė asmenys, kuriems diagnozuotas išsekimo sindromas; kontrolinę (n=25) – asmenys, neturintys išsekimo sin­dromo. Tyrimo metu buvo taikoma anketinė apklausa, apimanti sociodemografinių duomenų rinkimo anketą, trumpąjį protinės būklės klausimyną, geriatrinės depre­sijos skalę (trumpąją versiją), išsekimo sindromo anketą, bei ėjimo greičio ir plaštakų jėgos vertinimo metodus, remiantis Fried kriterijais. Statistinei duomenų analizei naudotos Excel 20 ir SPSS programos. Tyrimo rezultatai parodė, kad senatvinio išsekimo sindromo pasireiškimas reikšmingai priklauso nuo amžiaus ir šeiminės padėties, o tiriamųjų kognityviniai sutrikimai reikšmingai lemia de­presiškumo požymių pasireiškimą (p<0,001). Nustatyta, kad depresiniai simptomai dažniau pasireiškia asmenims, turintiems išsekimo sindromą (r=0,517; p<0,001), ypač vyrams. Depresiškumo požymių analizė parodė kore­liaciją tarp išsekimo sindromo ir nuobodumo, prastos nuotaikos, bejėgiškumo, atminties problemų, energijos stokos (p<0,05). Taip pat nustatyta sąsaja tarp geriatrinės depresijos skalės duomenų ir išsekimo sindromo požy­mių (kūno masės mažėjimo, nuovargio pasireiškimo, plaštakų jėgos ir fizinio aktyvumo lygio sumažėjimo, p<0,05). Galima daryti išvadą, kad vyresnio amžiaus asmenų kognityviniai sutrikimai reikšmingai dažniau pasireiškia tarp išsekimo sindromą turinčių asmenų ir yra susiję su depresiškumo požymiais.
HIPOTIREOZĖS VALDYMO IŠŠŪKIAI VARTOJANT PROTONŲ POMPOS INHIBITORIŲ: KLINIKINIS ATVEJIS
Authors: Jakimavičiūtė Gunda , Zabulienė Lina
Published: January 2025

Šis klinikinio atvejo tyrimas nagrinėja 44 metų moters, 18 m. sergančios pooperacine hipotireoze, ligos valdymo iššūkius ir kompleksiškumą. Vartojant stabilią levotirok­sino dozę 15 m. stebėta medikamentinė eutireozė ir op­timalūs tireotropinio hormono (TTH) rodikliai. Tačiau 2021 m. pradžioje, COVID-19 pandemijos metu, TTH rodiklis padidėjo. Palaipsniui didinta levotiroksino dozė. Nepaisant to, TTH rodikliai ir toliau blogėjo. Nustatyta, kad pacientė kiekvieną rytą savarankiškai vartoja pro­tonų pompos inhibitorių omeprazolį ir geležies papildus. Nutraukus omeprazolio vartojimą ir pakeitus geležies papildų vartojimo laiką, gerėjant TTH rodikliams le­votiroksino dozė buvo sumažinta. Be to, siekiant op­timalaus TTH ir medikamentinės eutireozės, buvo pa­skirtas trijodtironinas. Šis klinikinis atvejis parodė, kad būtina tinkamai, laiku ir nuosekliai gydyti hipotireozę, visapusiškai vertinant paciento būklę, reguliariai stebint paciento rodiklius ir taikant individualius priežiūros ir gydymo planus. Šios priemonės labai svarbios siekiant nustatyti ir pašalinti veiksnius, trukdančius įsisavinti le­votiroksiną, optimizuoti gydymo rezultatus, užtikrinti pacientų saugumą ir sumažinti komplikacijų, susijusių su skydliaukės funkcijos sutrikimu, riziką.
Integración de la Investigación y Emprendimiento en la Formación: Una Propuesta Metodológica
Authors: Claudia Patricia Montiel Castaño  , Magda Elizabeth Lopera Grisales
Published: January 2025

Este artículo titulado “Integración de la Investigación y el Emprendimiento en la Formación” tiene como objetivo principal presentar una metodología desarrollada como resultado de un proyecto de investigación aplicada. Esta metodología integra dos componentes esenciales en la formación profesional: la construcción de habilidades investigativas y el desarrollo de competencias en emprendimiento; se diseñó específicamente en el contexto de un programa de formación del nivel tecnólogo del Servicio Nacional de Aprendizaje (SENA); sin embargo, se destaca su intencionalidad pedagógica de ser escalable y adaptable a diversos programas formativos, ya sea en la formación para el trabajo o a nivel universitario. La gestión del conocimiento y la elección de modelos pedagógicos adecuados son fundamentales en la educación; a su vez, la formación multidisciplinaria se considera esencial para que los estudiantes puedan afrontar los retos del mercado laboral actual. En este sentido, el fomento de habilidades emprendedoras e investigativas se ha vuelto crucial para el éxito profesional. En este contexto, la metodología desarrollada proporciona una ruta holística para integrar la investigación y el emprendimiento en la formación, promoviendo así una cualificación integral orientada hacia las demandas cambiantes del entorno laboral actual.
Evaluating and Mitigating Cybersecurity Threats from System Update Vulnerabilities through the CrowdStrike Case
Authors: İş Hafzullah
Published: January 2025

The $5 billion update error in CrowdStrike’s security software led to global disruptions, affecting airports, hospitals, and banking systems. This issue, caused by a faulty software update, resulted in Microsoft Windows computers experiencing "blue screen" failures, impacting approximately 8.5 million devices globally and requiring manual restarts. The malfunction halted aviation, disrupted healthcare services, and disabled some TV channels. Insurance company Parametrix estimated $5.4 billion in losses for 25% of affected Fortune 500 companies in the US and around $15 billion globally.
This paper examines the cybersecurity risks associated with vulnerabilities introduced by system updates, with a focus on critical infrastructures. To assess these risks, vulnerability scans were conducted across 12 critical infrastructure organizations, revealing an average 27% vulnerability rate related to updates. Through this study, we identify the evolving threat landscape and propose mitigation strategies to enhance cybersecurity posture, targeting a performance improvement of over 90%.
Curious Case of the Jew Who Married a Buffalo
Authors: Mampieri Martina
Published: January 2025

This article examines an unpublished Italian composition, Morte data ad un Ebreo che si sposò con una bufala, preserved in manuscripts from Italian and European libraries. The text, written in the form of a trial, narrates the case of an alleged blood libel in Hamburg (1687). According to the story, a Jewish merchant, guided by a kabbalist, supposedly married a buffalo as part of a kabbalistic ritual. Their half-human, half-buffalo child born from this unnatural union turned seven, his father killed a Christian boy to use his blood for the ritual. The narrative concludes with the merchant’s execution and the child’s imprisonment. Likely fabricated by detractors with superficial knowledge of Kabbalah and Sabbateanism, the story blends slander and fiction. This paper aims to disentangle fiction from historical fact, analyse the composition’s context, and explore its circulation, paving the way for a critical edition and deeper insights into its unsettling narrative.
Increasing the accuracy of diagnosing biological tissues using digital image processing
Authors: F. Nori Abbas , K. Sarhan Dhamya
Published: January 2025

In diagnosing diseases, researchers and specialists usually rely on direct viewing with a microscope at a tissue sample to identify good tissue from the patient. Therefore, this paper was concerned with improving the accuracy and illustrate of biological tissue images by relying on a computer program, which is MATLAB, to perform image processing operations for images obtained from the microscope camera to illustrate it in a good way, so that specialists can make the best diagnosis using these results. Since there are many images of tissues that differ in terms of lighting, this paper relied on several illustration processes in two programs. The first focused on using histograms, it was based on a comparison between the original image and the image that was processed by spreading the histogram lighting once, and again with an image that was processed several times to get the best result, in addition to comparison with binary images and grayscale images. The second focused on detecting the edges of the image and using the complementary image. Several types of edge detection were used, the first using the detection function, the second using the Sobel filter, and the third using the Canny filter, through the results of the histogram and visual observation, it was found that the method of distributing histogram lighting is the best in obtaining distinctive results, after that complement of the image.
The Impact of Municipal Wastewater on the Concentrations of Amino Acids in Polluted Water
Authors: Al-Haidarey Mohammed Jawad , Al-Zubaidi Hanan Abbas Majeed
Published: January 2025

The study investigates the influence of sewage on water quality. Total organic carbon (TOC) and total nitrogen (TN) concentrations were highest at the site closest to sewage discharge, indicating increased organic matter and nitrogenous compounds. Total protein (TPs) concentrations followed the same pattern as TN, further supporting the impact of sewage. Amino acid concentrations were significantly higher at the polluted site, suggesting their formation from decomposing organic matter by bacteria. Glycine and Arginine concentrations did not differ significantly across sites, indicating they may not be reliable indicators of water health. The study proposes using amino acid levels, especially those elevated at polluted sites, as indicators of water quality and organic load. Further research is recommended to investigate bacterial communities and their influence on amino acid diversity.
Effect of Different Temperature and Light Spectrum on the Growth and Chlorophyll Pigment Content of Green algae
Authors: Mahmoud Shaker Heba , Alzurfi Sadiqk.
Published: January 2025

Chlorophyll produced by photosynthetic organisms such as plants, algae, and microbes can serve as a chemoprotective agent with potential health benefits when consumed as a dietary supplement. The current study aimed to investigate the effects of temperature and light spectrum on chlorophyll production in the microalga Chlorella vulgaris. An incubator with three compartments providing distinct red, blue, and white light spectra was designed to grow algal cultures. Four replicates per treatment were incubated for 21 days, with optical density, growth rate, biomass, and chlorophyll pigments quantified at regular intervals. Over time, optical density, growth rate, and biomass increased significantly at temperatures of 20°C, 25°C, and 30°C, while doubling time decreased. Maximum chlorophyll concentrations were attained on day 18 under red light at 25°C (1.22 μg/L), while minimum concentrations occurred on day 1 under white light at 25°C (0.06 μg/L). For chlorophyll b, highest levels were reached on day 18 with red light at 30°C (1.23 μg/L) and lowest on day 1 with white light at 30°C (0.04 μg/L). In summary, this study demonstrates that light spectrum and temperature significantly influence C. vulgaris growth and chlorophyll production, with red light and moderate temperatures promoting optimal chlorophyll biosynthesis. Careful control of cultivation conditions could maximize yields of this health-promoting pigment.
Relationship of biofilm strength levels in Candida albicans isolates with the type of clinical specimens
Authors: Al-sabti Kawther Hafez Jabbar , Ali Hussain Shabaa Raed
Published: January 2025

The virulence factors in C. albicans such as biofilm formation, germ tube, adhesion, hydrolytic enzymes, such as lipases, proteases, phospholipases, and hemolysin and catalase enzyme that allow successful colonization and infection of the host under suitable predisposing conditions. A total of 151 clinical specimens were collected from immunocompromised patients suffering from underlying diseases included cancer, diabetes, and thalassemia. All the collected specimens were cultured on yeast selective media. From the total clinical specimens 111 (73.50%) specimens were positive for yeast growth, among them the most predominant species was C. albicans at 64 (57.65%). There was a difference in the prevalence of yeast species isolates according to the patient’s gender, which it was higher in females 76 (68.46%) than in males 35 (31.53%), The virulence factors results showed that all isolates belonging to the species C.albicans form the germ tube when incubated at a temperature of 37°C for 3 hours in 0.5 ml of human serum  while all the isolates of C. albicans showed a positive result to adhesion test after incubation for 1h at 37Cº The test results showed that from 64 C. albicans isolates, there were 16 (25%) strong biofilm producers, 6 (14.28%) were considered as weak biofilm producers. The studies described here form the basis for investigations into the mechanisms of Candida bioﬁlm formation and provide the means to design novel therapies for bioﬁlm-based infections.
Skin histological development in rat embryos exposed to chitosan nanoparticles
Authors: M Khalfa Hydar , L al-msaid Haider
Published: January 2025

Chitosan is a natural nontoxic biopolymer derived by the deacetylation of chitin. Chitosan and its derivatives have attracted considerable interest due to their antimicrobial and antifungal activity.1–3 Chitosan exhibits its antibacterial activity only in an acidic medium because of its poor solubility above pH6.5.4 The antibacterial activity of chitosan is influenced by a number of factors that include the type of chitosan, the degree of chitosan polymerization and some of its other physicochemical properties. The present study was conducted to investigate the damage induced by chitosan nanoparticles at various concentrations on embryonic skin histogenesis . Material and methods: chitosan nanoparticles were synthesized via the ionotropic gelation of chitosan with TPP (sodium tripolyphosphate) anions. . Laboratory  pregnant wistar albino rats were injected with different bolus doses of chitposan nanoparticles intraperitoneally and rat pups were dissected after delivery . skin tissues from rats pups were  examined histologically and compared to control animals. Results: histological examination of all tissues in both groups shows gradual cytotoxic effect of chitosan nanoparticles reaching extreme histological damage with increased bolus dose. Skin damage included hemorrhaging and distruption of epidermal layers.  a decrease in epidermal thickness between the control group and the groups treated with different cyclophosphoamide concentrations Conclusion: This study concludes that chitosan nanoparticles have a strong cytotoxic effect on rat embryonic skin histogensis . Morphological appearance shows variable cell changes to include apoptotic changes as well as nuclear damage. Cytotoxic effect and histological damage is confirmed by the gradual decrease in epidermal thickness of rat pups as well the profound histological changes that is seen in various organs of rat pups.
Expression of Genetically Engineered BL21(DE3) with the Staphylokinase Gene from Staphylococcus aureus
Authors: Farhad Salah Hêro , Kamal Khider Adel , Muniandy Sekaran
Published: January 2025

The current study aimed to obtain staphylokinase (Sak) protein as a fibrinolytic agent from Escherichia coli as a nonpathogenic bacterium after transforming it with a cloned vector. From 630 clinical samples, 98 isolates of S. aureus were obtained and 81 (82.65%) were Sak producers. PCR amplification of the sak gene identified a single DNA band with the expected length of 408 bp in three S. aureus isolates. E. coli DH5a was successfully transformed with the sak gene.  PCR amplification showed that the recombinant gene comprised 408 bp, which was the same size as the native gene amplified from S. aureus. Bacterial proteins of genetically engineered BL21(DE3) with cloned pET-28a-sak  were separated according to their molecular weight and recombinant Sak appeared as a band with an estimated molecular weight ca 15.5 KDa. A non-induced sample with cloned vector was included as control. The fibrinolytic activity of recombinant Sak was higher than that of the native Sak. We found that the gene expression level and Sak production rate in the genetically engineered BL21(DE3) were similar to those of the native S. aureus.Key words: Cloning, fibrinolytic property, isopropyl b-D-1-thiogalactopyranoside, protein expression, staphylokinase
ANALISIS HUBUNGAN SEBARAN TOTAL SUSPENDED SOLID (TSS), SUHU PERMUKAAN LAUT DAN SALINITAS MENGGUNAKAN CITRA LANDSAT-8 STUDI KASUS WILAYAH PESISIR PANTAI KETINGAN SIDOARJO
Authors: O.A Indra Putra , Wibisana Hendrata , Zainab Siti
Published: January 2025

Pantai Ketingan sudah tidak asing bagi masyarakat Sidoarjo, selain karena menjadi objek wisata pantai di Kab. Sidoarjo dengan ekosistem hutan bakau sebagai wisata mangrove, juga memiliki nilai sejarah sehingga menjadikan tempat wisata ziarah. Banyaknya aktifitas yang terjadi di sekitar daerah Ketingan dapat mempengaruhi kualitas air pantai ketingan itu sendiri, jika kualitas airnya buruk dapat merusak pontensi pantai ketingan. Berdasarkan latar belakang tersebut perlu dilakukan penelitian pengukuran kualitas air untuk memantau persebaran Total Suspended Solid (TSS), Suhu Permukaan Laut dan Salinitas tahun 2023 di Pantai Ketingan menggunakan Citra Satelit Landsat 8. Hasil analisa menunjukan bahwa nilai data insitu untuk Total Suspended Solid sebesar 61 (mg/l) - 152 (mg/l) dan untuk suhu permukaan laut insitu Perairan Ketingan Sidoarjo berkisar diantara 18,4Â°C - 24,4Â°C sedangkan untuk Salinitas insitu berkisar diantar 31 (ppt) - 34 (ppt). Dari data citra dengan nilai korelasi tertinggi diperoleh nilai Total Suspended Solid sebesar 99,60 (mg/l) â€“ 110.82 (mg/l) dan untuk suhu permukaan laut berkisar diantara 19,41Â°C - 24Â°C sedangkan untuk Salinitas berkisar diantar 32,36 (ppt) - 34,57 (ppt). Sedangkan nilai korelasi antara Total Suspended Solid (TSS) dan Suhu Permukaan Laut dihasilkan dengan uji korelasi yang bernilai -0.999974332 yang artinya pada kedua variabel tersebut memiliki nilai korelasi negatif sangat kuat. Untuk nilai korelasi antara Total Suspended Solid (TSS) dan Salinitas menghasilkan nilai korelasi sebesar 0.341614101 yang artinya pada kedua variabel tersebut memiliki nilai korelasi positif cukup rendah. Maka dari itu penelitian ini dapat menjadi acuan dalam penelitian berikutnya dan memetakan sebaran Total Suspended Solid (TSS), Suhu Permukaan Laut dan Salinitas serta memantau kenaikan maupun penurunan Total Suspended Solid (TSS), Suhu Permukaan Laut dan Salinitas. Sehingga dapat memberi solusi yang tepat dalam pengambilan keputusan terhadap dampak lingkungan sedangkan pada bidang Teknik Sipil disektor perencanaan dan pembangunan bangunan air seperti pelabuhan dan dermaga, penelitian ini juga dapat digunakan sebagai basis data.
ANALISIS BANGKITAN PERJALANAN TERHADAP PUSAT GROSIR SURABAYA DI KAWASAN SURABAYA PUSAT
Authors: Pratama Maulana Riezal , Utomo Nugroho , Estikhamah Fithri
Published: January 2025

Adanya pandemi membuat aktivitas perdagangan terganggu yang membuat para pelaku usaha di Pusat Grosir Surabaya gulung tikar dan ada beberapa para pelaku usaha masih bertahan hingga sekarang. Agar bisnis mereka dapat bangkit kembali, pengelola Pusat Grosir Surabaya sedang mengupayakan untuk membangkitkan kembali daya tarik konsumen agar Pusat Grosir Surabaya kembali dalam keadaan ramai pengunjung. Oleh karena itu penelitian ini perlu dilakukan untuk mengetahui faktor â€“ faktor yang berpengaruh terhadap jumlah bangkitan perjalanan, mencari model bangkitan terbaik dan mengetahui berapa banyak bangkitan pergerakan di Pusat Grosir Surabaya saat ini serta memprediksi jumlah pengunjung pada proyeksi umur rencana lima tahun mendatang.
Penelitian ini dilakukan untuk menganalisis dampak dari bangkitan pergerakan pada lokasi tersebut, dan meramalkan jumlah pengunjung pada Pusat Grosir Surabaya menggunakan metode regresi linear berganda (multiple linear regression analysis) yang kemudian dilanjutkan dengan analisis trip generation menggunakan metode Detroit.
Dari hasil penelitian diperoleh sebaran perjalanan mengunakan metode Detroit sebesar 102 perjalanan pada 5 tahun yang akan datang dengan total pertumbuhan 13,98% per tahun. Dari persamaan regresi linear berganda didapatkan model persamaan bangkitan dengan variabel bebas (X1) adalah usia dan variabel (X2) adalah jenis pekerjaan, karena berpengaruh terhadap bangkitan (Y). Didapatkan prediksi jumlah pengunjung Pusat Grosir Surabaya di Kawasan Surabaya Pusat sebesar 355.814 pengunjung dengan tingkat pertumbuhan
pengunjung 20,2% dalam 5 tahun yang akan datang.
Evaluating the Efficacy and Safety of a Multidrug Brachial Plexus Block Regimen Combining Lidocaine, Bupivacaine, and Dexamethasone for Major Upper Limb Surgeries in Bangladesh
Authors: Pervej Dr Abu Muhammad Abdullah , Kaiser Dr. Khaled , Rahman Dr. Mohammod Shajedur , Akhter Dr. Shamima , Sikder Dr. Md. Enamul Islam , Ibrahim Dr. Mohammad , Nasif Dr. T M Fahad , Dey Dr. Shishir , Nujha Dr. Afruza Nadia , Alam Dr. Ashraful , Hossain Dr. Md. Murad
Published: January 2025

Background: Brachial plexus block is a widely used regional anesthesia technique for upper limb surgeries. Multidrug regimens incorporating lidocaine, bupivacaine, and dexamethasone aim to enhance block efficacy while maintaining safety. This study evaluates the comparative efficacy and safety of three brachial plexus block regimens using lidocaine, bupivacaine, and dexamethasone in patients undergoing upper limb surgeries. Methods: A retrospective cohort study was conducted involving 150 patients undergoing upper limb surgeries. Block efficacy was assessed through the onset and duration of sensory and motor blockades, along with pain scores using the Visual Analog Scale (VAS). Safety outcomes were determined by analyzing the incidence of adverse effects, including nausea, vomiting, hypotension, bradycardia, and local anesthetic systemic toxicity (LAST). Comparative analyses among groups were performed using appropriate statistical tests. Results: Group C (lidocaine + bupivacaine + dexamethasone) demonstrated the shortest onset times for sensory (5.6 ± 1.1 min) and motor (7.5 ± 1.2 min) blocks and the longest block durations for sensory (15.8 ± 2.2 hours) and motor (14.5 ± 2.1 hours) blocks compared to Groups A and B (p < 0.001). Pain scores at 6 and 24 hours were significantly lower in Group C (VAS 1.5 ± 0.7 and 3.8 ± 1.1, respectively; p < 0.001). Safety outcomes were comparable across groups, with a low incidence of adverse effects and no cases of LAST. Conclusion: The combination of lidocaine, bupivacaine, and dexamethasone in a brachial plexus block significantly improves block efficacy and duration while maintaining a favorable safety profile. This multidrug regimen holds promise for optimizing perioperative outcomes in upper limb surgeries, warranting further prospective studies for validation.
Fertility Restoration Following Myomectomy and Unilateral Oophorectomy for Large Fibroid and Ovarian Tumor: A Case Report
Authors: Ghosh Supriti Rani , Das Barun Kumar
Published: January 2025

This case report details the effective surgical management of a 24-year-old woman presenting with a large intramural fibroid and an ovarian cystic tumor, with an emphasis on fertility preservation. The patient, experiencing clinical symptoms, underwent a myomectomy and unilateral oophorectomy after a thorough preoperative assessment. A Pfannenstiel incision was utilized under spinal anesthesia to ensure optimal surgical access and complete excision of the pathologies while preserving reproductive structures—postoperative care involved close monitoring and supportive therapies, with hormonal assessments confirming normal endocrine function, and treatment for adenomyosis, right hydrosalpinx, and pelvic fluid. In 2020, additional treatments addressed acyclic bleeding and a myoma. Follow-up imaging showed a normalized uterine cavity, and the patient's menstrual cycle resumed within three months. Remarkably, she achieved natural conception eight months after getting married and delivered a healthy, full-term infant. This case highlights the importance of meticulous surgical planning, precise execution, and comprehensive postoperative follow-up in achieving favorable fertility outcomes in complex gynecological cases.
Antibiomania: A Case Report of Amoxicillin Clarithromycin and Metronidazole Induced Manic Episode
Authors: Khallouk A. , Stati S. , Boukdir A. , Rhaouti A. , Belbachir S. , Ouanass A.
Published: January 2025

Introduction: Antibiomania is characterized by the onset of a manic episode in response to antibiotic use. Although relatively rare, this type of adverse effect is increasingly documented and primarily occurs in patients without a history of bipolar disorder. Several dozen cases have been reported in the literature, showing the emergence of manic symptoms following antibiotic administration, notably clarithromycin, which is one of the most frequently involved antibiotics. Clinical Case: We report the case of a 56-year-old patient who experienced a manic episode after receiving triple antibiotic therapy to eradicate Helicobacter pylori in the context of a gastroduodenal ulcer. Two days after starting treatment, behavioural disturbances appeared, characterized by irritability, aggressiveness, logorrhoea, insomnia, and a mystical delirium. Upon hospitalization, the patient exhibited acute delirious symptoms congruent with manic mood, such as grandiosity and psychomotor agitation. Brain magnetic resonance imaging (MRI) was normal. Antibiotic treatment was immediately discontinued, and treatment with sodium valproate (1,5g/day) and olanzapine (10 mg/day) was initiated. A rapid clinical improvement was observed, with the resolution of delusional ideas within a week. The patient returned to a euthymic state, and his treatment was maintained for preventive purposes. Discussion: This clinical case raises several questions: Are there predictors of Antibiomania? Is there a risk of recurrence of mood episodes after an episode of Antibiomania? What are the pathophysiological mechanisms that would explain this reaction? In all identified cases, discontinuation of antibiotics has been a determining factor. However, the introduction of psychotropic treatment and its duration remain uncertain. First, longitudinal follow-up would allow for the evaluation of this variable. Second, the presence of personal psychiatric history is not clearly established as a predictor of ...
DESAFIOS NO MANEJO DA POLIFARMÁCIA EM IDOSOS: ESTRATÉGIAS PARA A FARMÁCIA CLÍNICA
Authors: Vieira Carlos Eugênio da Costa , Pinheiro Maria Tarcila Rabelo
Published: January 2025

O envelhecimento populacional é uma característica global que gerou mudanças significativas nos sistemas de saúde. O aumento da expectativa de vida traz novos desafios para a saúde pública, especialmente no que se refere à prevenção e ao manejo de doenças crônicas, além do uso racional de medicamentos. Nesse contexto, a polifarmácia, definida como o uso simultâneo de cinco ou mais medicamentos, tornou-se uma preocupação crescente entre os profissionais de saúde, devido aos riscos associados, como reações adversas, interações medicamentosas. A relevância deste estudo consiste em analisar os desafios e as estratégias externas para o manejo da polifarmácia em idosos, com ênfase na atuação da farmácia clínica. Trata-se de uma revisão narrativa de literatura, cuja busca por artigos foi realizada nas bases de dados PubMed, SciELO, Lilacs e Google Acadêmico. Os critérios de inclusão adotados foram: publicações entre os anos de 2013 e 2024, nos idiomas português, inglês ou espanhol, que abordavam diretamente o tema. Foram excluídos artigos que não tratavam do tema de forma central, estudos duplicados em diferentes bases de dados, bem como publicações no formato de editoriais, cartas. Os resultados revelaram diversos desafios relacionados ao manejo da polifarmácia em idosos, evidenciando que essa prática, em constante crescimento nas populações envelhecidas, está diretamente associada ao aumento de eventos adversos relacionados aos medicamentos (ERMs), à redução da qualidade de vida e ao incremento dos custos com serviços de saúde. Por meio disso, conclui-se que o manejo adequado da polifarmácia em idosos requer uma abordagem integrada e multidisciplinar, na qual a farmácia clínica desempenha um papel central.
The role of 18F-fluorodeoxyglucose positron emission tomography/computed tomography in the detection of brown tumors: A case series
Authors: Oueriagli Salah Nabih , Dribla Ayoub , Sahel Omar Ait , Ameur Yassir Ben , Doudouh Abderrahim
Published: January 2025

We present two cases of chronic hemodialysis patients with suspicious lytic pelvic bone lesions in the context of secondary hyperparathyroidism (HPT). Bone biopsies were inconclusive. 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) scans revealed highly hypermetabolic lytic lacunar bone lesions scattered throughout the skeleton. Pathological 99mTc-hexakis-methoxy-isobutyl-isonitrile (99mTc-MIBI) uptake in the cervical region suggested parathyroid tissue involvement, while whole-body 99mTc-MIBI scintigraphy did not reveal pathological uptake. Brown tumors were strongly suspected based on clinical and laboratory evidence of HPT, ruling out malignancy. Our cases suggest the superior sensitivity of 18F-FDG PET/CT in detecting and characterizing brown tumors compared to whole-body 99mTc-MIBI scintigraphy. This examination offers crucial insights into characterizing brown tumors based on morpho-metabolic criteria, minimizing inaccurate diagnosis of this pathological condition.
Therapeutic potential of green formulation of Silybum marianum-based zinc nanoparticles on cervical cancer
Authors: Zangeneh Mohammad Mahdi , Zangeneh Akram
Published: January 2025

Silybum marianum possesses numerous therapeutic properties and has the potential to inhibit the spread of cancer. Research indicates that this plant can prevent the proliferation of cancer cells. It is likely that S. marianum could enhance the efficacy of chemotherapy. In addition, the adverse effects of current treatments could potentially be alleviated through the use of this plant. While the U.S. Food and Drug Administration has not officially approved S. marianum for carcinoma treatment, it shows promise in treating various types of cancer such as skin, small intestine, blood, cervical, breast, and prostate cancers. The primary focus of research is the exploration of metallic nanoparticles (NPs) formulated with medicinal plants. In this study, we successfully synthesized S. marianum-based zinc NPs (Zn-NPs). Various characterization techniques such as transmission electron microscopy, field-emission scanning electron microscopy (FE-SEM), Fourier-transform infrared spectroscopy (FT-IR), and ultraviolet–visible spectroscopy were employed. The DPPH inhibition efficiency was determined using DPPH method, while the MTT assay was utilized to assess the cytotoxic effects of the Zn-NPs on HT-3, LM-MEL-41, C-33 A, and SiHa cells. The findings from the FE-SEM indicated that the NPs appeared spherical with some degree of aggregation. Furthermore, the FT-IR analysis identified peaks at 472 and 518 cm-1, which can be attributed to Zn-O bond. The IC50 values of the Zn NPs against HT-3, LM-MEL-41, C-33 A, and SiHa cervical cancer cells were 161, 125, 155, and 108 μg/mL, respectively. In conclusion, these findings showed that S. marianumbased Zn NPs possess potential benefits in treating cervical carcinoma.
Genotypic diversity of human and porcine group A rotaviruses in Uttar Pradesh, India
Authors: Dudhe Nitin , Bhilegaonkar Kiran , Abass Gazanfar , Rawat Shriya , Singh Vibha , K. Rajak Kaushal , Kumar Obli Rajendran Vinodh , Singh Malik Yashpal , Baburao Dubal Zunjar
Published: January 2025

Diarrheal diseases, particularly those caused by rotaviruses, pose a significant health threat, especially among children, and cause huge economic losses to the pig industry in the form of high morbidity, mortality, and stunted growth. Rotavirus A (RVA) remains the predominant viral agent for severe diarrheal episodes, contributing to high hospitalization and mortality rates in India. RVA’s high genetic diversity is attributed to frequent reassortment and mutations. This study aims to characterize the VP4, VP6, VP7, and NSP4 genes of RVA in stool samples collected from children and piglets in and around Bareilly, Uttar Pradesh, India. A total of 300 samples, including 100 from children and 200 from piglets, were screened for the detection of double-stranded RNA of RVA using ribonucleic acid-polyacrylamide gel electrophoresis (RNA-PAGE) and reverse transcription polymerase chain reaction (RT-PCR). Results revealed the RVA incidence, particularly in winter (end of November to beginning of February), aligning with observed seasonal trends. Among the 32 Rotavirus (RV)-positive samples from children, 21 (65.63%) were detected by RNA-PAGE, whereas 28 (87.5%) were identified by RT-PCR. Whereas, of the 80 RT-PCR positive samples from piglets, only 51 (63.75%) were detected by RNA-PAGE, indicating the superiority of RT-PCR. Molecular analysis identified the prevalent genotypes in human strains as G1, G2, G3, and P[8], whereas G9P[13]-I5-E1 dominated among piglets in a single farm outbreak. The findings underscore the critical need for continuous surveillance to monitor evolving RV genotypes from both humans and piglets, enabling the identification of new strains of RVA and subsequent modification of vaccination strategies to reduce RVA’s impact in India.
Transformative natural product-drug combinations: Advancing techniques to enhance efficacy against drug-resistant pathogens
Authors: Gideon Mathew
Published: January 2025

This review explores the development, modification, and optimization of potent active compounds using combinatorial synthetic methods that incorporate phytoconstituents from plant extracts, aiming to enhance efficacy and mitigate resistance. Attenuated total reflectance-Fourier transform infrared spectroscopy, gas chromatography-mass spectrometry (GC-MS), and antibacterial data from the literature were employed to validate these strategies. The methodology emphasized precise harvesting, pre-treatment, and extraction processes to ensure the quality and efficacy of the plant extracts. Various extraction methods and solvents were used to isolate specific phytoconstituents, followed by further purification through chromatography. The review proposes three strategies: (i) reacting single or multiple plant extracts with reagents such as acids or catalysts, (ii) combining plant extracts with ineffective drugs to induce structural changes that enhance antibacterial efficacy, and (iii) integrating plant extracts with drugs not originally intended for the target disease to explore new structural functionalities. Significant findings include synergistic effects observed when Psidium guajava and Calotropis procera extracts were combined with antibiotics, leading to substantially increased zones of inhibition against resistant bacteria. GC-MS analysis identified numerous bioactive compounds, some of which with known anticancer properties, suggesting potential applications beyond antibacterial effects. These innovative combinatorial approaches demonstrate the potential to yield new compounds with enhanced pharmacological properties, highlighting the critical role of plant extracts in drug discovery and development. This review underscores the promise of harnessing natural products to combat multi-drug resistance, paving the way for advanced research and development in pharmaceutical applications.
Hypnosis as an effective psychosomatic intervention for globus pharyngeus: A case report
Authors: Ron Yorai , Keller Shikma
Published: January 2025

Globus pharyngeus is a common condition characterized by a persistent or intermittent sensation of a lump in the throat, affecting 21.5 – 46% of the population. Its multifactorial etiology includes both physical causes, such as pharyngoesophageal irritation, and psychological factors, such as anxiety, making it a challenging condition to treat. This case report examines the phenomenon of globus pharyngeus and explores the effectiveness of hypnosis as a treatment option. We present the case of an 18-year-old male who lost nearly 30 kg of body weight due to his reliance on liquid consumption, as he was unable to swallow solid food because of the globus sensation. The chosen therapeutic intervention was hypnosis. By the fourth session of a planned 10-session program, the patient was able to consume solid foods without experiencing the globus sensation and began to regain weight. This case highlights the potential of hypnosis as an effective treatment option in the treatment of psychosomatic conditions, such as globus pharyngeus.
Athletes’ perception of their coach transformational leadership and coach-athlete relationship in team and individual sports
Authors: Ahmad Radzi Jamilah , Salimee Muhammad Fitri , Mohd Kassim Ahmad Fikri
Published: January 2025

Coach is a person who has influential figures, leads and engages in a wide range of roles. Sports coaches play important roles in sport as being responsible for numerous outcomes relevant to athlete development, learning and performance. Transformational leadership has been shown to have positive impacts on a wide range of sport outcomes. Furthermore, the coach-athlete relationship is vital to many outcomes such as satisfaction, well-being and self-concept. Therefore, the current study aimed to examine athlete's perception of coach transformational leadership and coach-athlete relationship in team and individual sports. The sample comprised of 156 university athletes which includes team (Football n = 34, Netball n = 22, Frisbee n = 30) and individual (Athletics n = 22, Badminton n = 20, Tennis n = 28). Each participant completed the Differentiated Transformational Leadership Inventory and the Coach-Athlete Relationship Questionnaire. Results revealed that there was a significant difference in component of the coach-athlete relationship between team and individual sport, whilst there was no significant difference between components of transformational leadership with team and individual sport. Results also showed that there was no significant difference between the components of the coach-athlete relationship with gender. There was also no significant difference on components of transformational leadership with gender except component of idealized influence. The results of this study could provide insight toward an athlete's perception of their coach transformational leadership and the quality of the coach-athlete relationship in different sport categories. Therefore, to increase the positive youth development in sports through transformational leadership behavior and the quality of coach-athlete relationship more study should be examined.
Aspects of Lifestyle to Stimulate the Success of Badminton Players
Authors: Aman Mohd. Salleh , Nik Rafeddi Nik Syerie Nursara , Mat Saad Mohamad Ikram , Elumalai Gunathevan
Published: January 2025

Lifestyle is the way of life or interests and orientations of an individual, group, or community. Lifestyle of a badminton player is the style of living that based on time-used, discipline and appearances. Known benefits of having a lifestyle that includes physical exercise, eating a diet high in vegetables and fruit, maintaining a healthy weight and not smoking. The aim of this study is to identify the social category aspects of lifestyle stimulate the success of badminton players. This semi structured mix mode study conducted among 80 badminton players, age between 13 to 18 years. They were selected randomly at several badminton clubs around the State of Selangor. This study utilized qualitative data which is converted to quantitative to understand behaviours of the group of people and make generalizations. The descriptive findings showed 32.5% use their free time in entertainment activities, 27.5% engage in their hobby activities and 23.75% choose to do physical recreational activities. Out of 80 respondents, a total of 35% acknowledging that rules and regulations are important in badminton as well as in life. A total of 32.5% asserted that the strength of discipline adhering to desire plays an important role. Meanwhile, 25% of badminton players' discipline is focused on maintaining performance. There are four elements of appearance, namely confidence, discipline, nationalism and equipment. Out of 53 respondents who said appearance was important, 64.2% were focused on confidence, 17% discipline, 9.4% nationalism and 9.4% equipment. As a conclusion three major aspects of lifestyle to be concerned by badminton players were time-used, discipline and appearance. These three aspects will enhance our badminton players’ life style and performance.
Instrument reliability test for Prosocial and Antisocial behavior of school athletes in Indonesia
Authors: Dwitya I Made Widiarsa , Tomoliyus Tomoliyus
Published: January 2025

The purpose of this study is to examine the psychometric nature of athletes regarding prosocial and antisocial behavior in sports. The sample of this research is athletes in junior high or high school in the Special Region of Yogyakarta and the Province of Bali. For prosocial behavior, the reliability test showed a statistical data of 0.780 for the school athletes in the Special Region of Yogyakarta and 0.775 for the school athletes in the Province of Bali. For the antisocial behavior, results showed 0.817 for the school athletes in the Special Region of Yogyakarta while 0.501 for the school athletes in the Province of Bali. This study concludes that Prosocial and Antisocial Behavior in Sport Scale (PABSS) can be used to measure the prosocial and antisocial behavior of junior high school athletes and senior high school athletes in various regions of Indonesia. It was also found that PABSS can be used with different genders.
Topological Analysis of Fractal Binary and Ternary Trees
Authors: K Thanga Rajeswari , A Manimaran
Published: January 2025

Fractals are complex geometric objects that seem the same at different scales and have self-similarity. Because of this special characteristic, fractals can be used to simulate intricate biological processes. Fractal binary and ternary trees are novel data types that combine the productiveness of tree architectures with the ideas of fractal geometry. In addition to self-similarity and scalability, these trees have potential across a range of computer science and medical applications. The main goal of the study is to identify and analyze topological indices and graph entropy for fractal binary and fractal ternary trees. By examining indices such as the Randić index, Zagreb indices, and entropy measurements, the study aims to obtain a comprehensive knowledge of the structural complexity and information-theoretic properties of these fractal graphs. The study starts with the vertex and edge partitioning of fractal binary and ternary trees in order to distinguish different structural classes. Using these partitions, we obtained topological indices and graph entropy values for the fractal trees. Also, this study compares the topological indices for each fractal tree with the number of copies in the fractal dimension for a succession of graphs.
Integrating Sustainability Practices in Hospitality Management and Operations: An Analysis of Leadership Approaches, Green Certification, and Hotel Classification
Authors: Wisnawa I Made Bayu
Published: January 2025

The hospitality industry, as one of the largest consumers of energy, faces increasing pressure to adopt sustainability practices in the face of climate change and environmental damage. This study examines the role of participatory leadership, green certification, and hotel classification systems in integrating sustainability practices in the hospitality sector. By using qualitative descriptive methods through literature studies, this study identifies that the adoption of green technology and efficient operation can lower operational costs and improve public image. Furthermore, the study shows that green certification has a significant effect on guest booking decisions, signaling the importance of sustainability practices as a value-added in hotel marketing. Hotel classification systems that integrate sustainability standards offer a framework for assessing and categorizing hotels, encouraging hotels to continuously improve their sustainability practices. The results of this study are expected to provide insights for hotel managers to develop greener and socially responsible operational strategies, as well as support policies that promote environmental sustainability in hotel management.
The Role of Front Office Staff in Providing Satisfaction and Comfort for Guests at Radisson Golf and Convention Center Batam
Authors: Wijaya Hana , Sukmamedian Haufi , Lubis Arina Luthfini , Supardi Supardi
Published: January 2025

This study aims to analyze the role and contribution of Front Office staff at Radisson Golf and Convention Center Batam in creating a satisfying and comfortable guest experience. Front Office staff have the main responsibility in direct interaction with guests, such as reception, reservation handling, and check-in and check-out process. The research method used is descriptive method with quantitative and qualitative approaches, through questionnaire survey and in-depth interviews. The sample consisted of randomly selected Front Office employees and hotel guests. The results showed that although the contribution of Front Office employees has not reached the level of statistical significance (p = 0.052), there are positive indications that the improvement of their role has an impact on guest satisfaction. Factors such as communication skills, ability to handle complaints, and efficiency in service greatly influence guests' perception of hotel service quality. In addition, the findings also show that guests' personal preferences and the hotel's environmental conditions also influence the overall guest experience. Based on these findings, hotel management is advised to increase employee training in interpersonal skills and conflict handling, and improve internal communication systems between departments to enhance service coordination. This study provides important insights for hotel management in optimizing the role of the Front Office to improve guest experience.