bluuebunny/crossref_metadata_2025 huggingface dataset:
Antibacterial and Antiparasitic Activity of Propyl-Propane-Thiosulfinate (PTS) and Propyl-Propane-Thiosulfonate (PTSO) from Allium cepa against Gilthead Sea Bream Pathogens in In Vitro and In Vivo Studies
Authors: Cabello-Gómez Jose F. , Aguinaga-Casañas María Arántzazu , Falcón-Piñeiro Ana , González-Gragera Elías , Márquez-Martín Raquel , Agraso María del Mar , Bermúdez Laura , Baños Alberto , Martínez-Bueno Manuel
Published: October 2022

The use of phytogenic extracts is considered a sustainable strategy for the prevention of fish diseases, including Alliaceae as a potential option due to their variety of bioactive compounds. In this study, we analyzed the antibacterial and antiparasitic potential of propyl-propane-thiosulfinate (PTS) and propyl-propane-thiosulfonate (PTSO) from onions. The in vitro activity against Pseudomonas anguilliseptica, Tenacibaculum maritimum, and Photobacterium damselae of both compounds was tested. In addition, the viability of Sparicotyle chrysophrii larvae was evaluated. Moreover, a diet that consisted of a blend of PTS/PTSO (ALLIUM) was used. A total of 90 gilthead sea bream juveniles were tested against P. damselae subsp. Piscicida after 12 weeks of dietary administration. Furthermore, 150 fish with a rate of 10–15 parasites/fish were fed for 21 days and the number of gill parasites was recorded. All strains were sensitive to both compounds. PTSO showed the highest inhibitory effect against all target strains, while PTS showed higher effectiveness against S. chrysophrii. Fish from ALLIUM group presented the highest probability of survival, increasing up to 91.1%, whereas in the control group, the probability of survival was 66.7%. The number of parasites in the gilthead sea bream decreased in the ALLIUM group over time. These results suggest the inclusion of PTS and PTSO in feed as a natural strategy to prevent antibacterial and antiparasitic fish diseases.
Evaluation of Polycyclic Aromatic Hydrocarbons in Smoked Cheeses Made in Poland by HPLC Method
Authors: Polak-Śliwińska Magdalena , Paszczyk Beata , Śliwiński Mariusz
Published: October 2022

Smoked cheeses are particularly popular among consumers for their flavor and aroma. Of interest, therefore, is the health aspect related to the likelihood of polycyclic aromatic hydrocarbons (PAHs), which are known carcinogens found in smoked products. Thus, the purpose of this study was to evaluate the occurrence of 15 polycyclic aromatic hydrocarbons (PAHs) in smoked and non-smoked cheeses purchased in Poland to monitor their safety. The level of selected PAHs in cheese samples was determined using the HPLC-DAD-FLD method. Most of the cheeses tested met the maximum level of benzo[a]pyrene (2 μg/kg) and the sum of benz[a]anthracene, chrysene, benzo[b]fluoranthene and benzo[a]pyrene (12 μg/kg) established for these products. However, all the cheeses studied in this work had relatively low amounts of the sum of these compounds compared to the information available in the cheese literature, ranging from <LOD to 24.5 μg/kg. This amount does not pose a health risk to consumers. The predominant PAHs found were naphthalene, phenanthrene, fluorene and acenaphthene. Benzo[a]pyrene, the marker compound representing carcinogenic PAHs, was found in 100% and 0% of Polish smoked and non-smoked cheeses, respectively. Although there are currently no regulations for smoked cheeses and maximum concentrations of PAHs in this type of food product, control of PAHs content in cheeses is important due to the mutagenic and carcinogenic potential of these chemicals.
Supramolecular Design Strategy of a Water-Soluble Diphenylguanidine-Cyclodextrin Polymer Inclusion Complex
Authors: Guo Junqiang , Lin Liwei , Wang Yuping , Zhang Wang , Diao Guowang , Piao Yuanzhe
Published: October 2022

Diphenylguanidine (DPG) is a widely used secondary accelerator for the vulcanization of natural rubber (NR) latex. However, its low water solubility and high toxicity limit its use in high-end NR products. In this study, a water-soluble inclusion complex of DPG and a β-cyclodextrin polymer (β-CDP), termed DPG-β-CDP, was prepared through supramolecular interactions and characterized using Fourier-transform infrared spectroscopy, 1H NMR, scanning electron microscopy, and UV-vis spectroscopy techniques. In comparison with that of DPG, the water solubility of DPG-β-CDP was greatly enhanced because of the water-soluble host molecule. The molar ratio of DPG to the CD unit in β-CDP was determined to be 1:1. At 25 °C, the binding constant of DPG-β-CDP was found to be 9.2 × 105 L/mol by UV-vis spectroscopy. The proposed method for forming inclusion complexes with high potential for use as water-soluble vulcanization accelerators is promising.
High-Resolution Bioassay Profiling with Complemented Sensitivity and Resolution for Pancreatic Lipase Inhibitor Screening
Authors: Jian Jingyi , Yuan Jiaming , Fan Yu , Wang Jincai , Zhang Tingting , Kool Jeroen , Jiang Zhengjin
Published: October 2022

How to rapidly and accurately screen bioactive components from complex natural products remains a major challenge. In this study, a screening platform for pancreatic lipase (PL) inhibitors was established by combining magnetic beads-based ligand fishing and high-resolution bioassay profiling. This platform was well validated using a mixture of standard compounds, i.e., (-)- epigallocatechin gallate (EGCG), luteolin and schisandrin. The dose–effect relationship of high-resolution bioassay profiling was demonstrated by the standard mixture with different concentrations for each compound. The screening of PL inhibitors from green tea extract at the concentrations of 0.2, 0.5 and 1.0 mg/mL by independent high-resolution bioassay profiling was performed. After sample pre-treatment by ligand fishing, green tea extract at the concentration of 0.2 mg/mL was specifically enriched and simplified, and consequently screened through the high-resolution bioassay profiling. As a result, three PL inhibitors, i.e., EGCG, (-)-Gallocatechin gallate (GCG) and (-)-Epicatechin gallate (ECG), were rapidly identified from the complex matrix. The established platform proved to be capable of enriching affinity binders and eliminating nonbinders in sample pre-treatment by ligand fishing, which overcame the technical challenges of high-resolution bioassay profiling in the aspects of sensitivity and resolution. Meanwhile, the high-resolution bioassay profiling possesses the ability of direct bioactive assessment, parallel structural analysis and identification after separation. The established platform allowed more accurate and rapid screening of PL inhibitors, which greatly facilitated natural product-based drug screening.
Peptides as Potentially Anticarcinogenic Agent from Functional Canned Meat Product with Willow Extract
Authors: Wójciak Karolina M. , Kęska Paulina , Prendecka-Wróbel Monika , Ferysiuk Karolina
Published: October 2022

The aim of the study was to demonstrate canned pork as a functional meat product due to the presence of potentially anti-cancer factors, e.g., (a) bioactive peptides with potential activity against cancer cells; (b) lowering the content of sodium nitrite and with willow herb extract. In silico (for assessing the anticancer potential of peptides) and in vitro (antiproliferation activity on L-929 and CT-26 cell lines) analysis were performed, and the obtained results confirmed the bioactive potential against cancer of the prepared meat product. After 24 h of incubation with peptides obtained from meat product containing lyophilized herb extract at a concentration of 150 mg/kg, the viability of both tested cell lines was slightly decreased to about 80% and after 72 h to about 40%. On the other hand, after 72 h of incubation with the peptides obtained from the variant containing 1000 mg/kg of freeze-dried willow herb extract, the viability of intestinal cancer cells was decreased to about 40%, while, by comparison, the viability of normal cells was decreased to only about 70%.
MXene-Based Photocatalysts in Degradation of Organic and Pharmaceutical Pollutants
Authors: Iravani Siavash , Varma Rajender S.
Published: October 2022

These days, explorations have focused on designing two-dimensional (2D) nanomaterials with useful (photo)catalytic and environmental applications. Among them, MXene-based composites have garnered great attention owing to their unique optical, mechanical, thermal, chemical, and electronic properties. Various MXene-based photocatalysts have been inventively constructed for a variety of photocatalytic applications ranging from pollutant degradation to hydrogen evolution. They can be applied as co-catalysts in combination with assorted common photocatalysts such as metal sulfide, metal oxides, metal–organic frameworks, graphene, and graphitic carbon nitride to enhance the function of photocatalytic removal of organic/pharmaceutical pollutants, nitrogen fixation, photocatalytic hydrogen evolution, and carbon dioxide conversion, among others. High electrical conductivity, robust photothermal effects, large surface area, hydrophilicity, and abundant surface functional groups of MXenes render them as attractive candidates for photocatalytic removal of pollutants as well as improvement of photocatalytic performance of semiconductor catalysts. Herein, the most recent developments in photocatalytic degradation of organic and pharmaceutical pollutants using MXene-based composites are deliberated, with a focus on important challenges and future perspectives; techniques for fabrication of these photocatalysts are also covered.
A Literature Review of Artocarpus lacucha Focusing on the Phytochemical Constituents and Pharmacological Properties of the Plant
Authors: Sitorus Panal , Keliat Jane Melita , Asfianti Vivi , Muhammad Mahatir , Satria Denny
Published: October 2022

Studies have shown that approximately two-thirds of the plant species in the world have some medicinal value. Artocarpus lakoocha is a synonym for Artocarpus lacucha and is a plant that can be found in Indonesia. This medicinal plant has been used to treat many diseases. (1) Objective: This article discusses the scientific investigations carried out on A. lacucha, namely the plant’s chemical content, pharmacological activity, and active compounds. (2) Methods: The design of this study was based on an article that was a review of previous research. A search for relevant publications over the past ten years (2012–2022) using data from Pubmed, Proquest, Ebsco, ScienceDirect, and Google Scholar resulted in the discovery of 369 articles. (3) Results: Fifty relevant articles investigate A. lacucha’s substances and their applications in the health field. The presence of secondary metabolites and bioactive compounds has been reported, which is evidence that A. lacucha possesses antidiarrheal, immunostimulant, anticholesterol, and hepatoprotective agents. (4) Conclusions: Mobe (A. lacucha) is a plant native to North Sumatra, Indonesia. This plant is efficacious as an antioxidant, antibacterial, antidiarrheal, anti-inflammatory, analgesic, antinociceptive, schistosomicidal, hepatoprotective, neuroprotective, cytotoxic, antiglycation, and anticholesterol, and can also be used for anti-aging and wound healing. In addition to its various benefits, it turns out that this plant also has many active compounds that are useful to the health sector, especially the pharmaceutical field.
The Enhanced Recovery after Surgery (ERAS) Pathway Is a Safe Journey for Kidney Transplant Recipients during the “Extended Criteria Donor” Era
Authors: Angelico Roberta , Romano Francesca , Riccetti Camilla , Pellicciaro Marco , Toti Luca , Favi Evaldo , Cacciola Roberto , Manzia Tommaso Maria , Tisone Giuseppe
Published: October 2022

Enhanced recovery after surgery (ERAS) protocols are still underused in kidney transplantation (KT) due to recipients’ “frailty” and risk of postoperative complications. We aimed to evaluate the feasibility and safety of ERAS in KT during the “extended-criteria donor” era, and to identify the predictive factors of prolonged hospitalization. In 2010–2019, all patients receiving KT were included in ERAS program targeting a discharge home within 5 days of surgery. Recipient, transplant, and outcomes data were analyzed. Of 454 KT [male: 280, 63.9%; age: 57 (19–77) years], 212 (46.7%) recipients were discharged within the ERAS target (≤5 days), while 242 (53.3%) were discharged later. Patients within the ERAS target (≤5 days) had comparable recipient and transplant characteristics to those with longer hospital stays, and they had similar post-operative complications, readmission rates, and 5 year graft/patient survival. In the multivariate analysis, DGF (HR: 2.16, 95% CI: 1.08–4.34, p < 0.030) and in-hospital dialysis (HR: 3.68, 95% CI: 1.73–7.85, p < 0.001) were the only predictive factors for late discharge. The ERAS approach is feasible and safe in all KT candidates, and its failure is primarily related to the postoperative graft function, rather than the recipient’s clinical status. ERAS pathways, integrated with strict collaboration with local nephrologists, allow early discharge after KT, with clinical benefits.
Molecular Epidemiological Investigation of Piroplasms and Anaplasmataceae Bacteria in Egyptian Domestic Animals and Associated Ticks
Authors: Abdel-Shafy Sobhy , Abdullah Hend H. A. M. , Elbayoumy Mohamed K. , Elsawy Bassma S. M. , Hassan Mohamed R. , Mahmoud Mona S. , Hegazi Ahmed G. , Abdel-Rahman Eman H.
Published: October 2022

Piroplasmosis and anaplasmosis are serious tick-borne diseases (TBDs) that are concerning for the public and animal health. This study aimed to detect the molecular prevalence and epidemiological risk factors of Piroplasma and Anaplasma species in animal hosts and their associated ticks in Egypt. A total of 234 blood samples and 95 adult ticks were collected from animal hosts (112 cattle, 38 sheep, 28 goats, 26 buffaloes, 22 donkeys, and 8 horses) from six provinces of Egypt (AL-Faiyum, AL-Giza, Beni-Suef, Al-Minufia, Al-Beheira, and Matruh). Blood and tick samples were investigated by polymerase chain reaction coupled with sequencing targeting 18S and 16S RNA genes for Piroplasma and anaplasmataceae, respectively. Statistical analysis was conducted on the potential epidemiological factors. Of the 234 animals examined, 54 (23.08%) were positive for pathogens DNA distributed among the six provinces, where 10 (4.27%) were positive for Piroplasma, 44 (18.80%) for anaplasmataceae, and 5 (2.14%) were co-infected. Co-infections were observed only in cattle as Theileria annulata and Anaplasma marginale plus Babesia bigemina, A. marginale plus B. bigemina, and T. annulata plus B. bigemina. Piroplasmosis was recorded in cattle, with significant differences between their prevalence in their tick infestation factors. Animal species, age, and tick infestation were the potential risk factors for anaplasmosis. All ticks were free from piroplasms, but they revealed high prevalence rates of 72.63% (69/95) with anaplasmataceae. We identified T. annulata, B. bigemina, and A. marginale in cattle; A. platys in buffaloes; A. marginale and A. ovis in sheep; for the first time, A. ovis in goats; and Ehrlichia sp. in Rhipicephalus annulatus ticks. Our findings confirm the significant prevalence of piroplasmosis and anaplasmosis among subclinical and carrier animals in Egypt, highlighting the importance of the government developing policies to improve animal and public health security.
Antagonism of Rhizosphere Streptomyces yangpuensis CM253 against the Pathogenic Fungi Causing Corm Rot in Saffron (Crocus sativus L.)
Authors: Tian Li , Hu Shuang , Wang Xingxing , Guo Yingqiu , Huang Luyang , Wang Lili , Li Wankui
Published: October 2022

Plant diseases lead to a significant decline in the output and quality of Chinese herbal medicines. Actinomycetes play a vital role in the rhizosphere ecosystem. This is especially true for Streptomyces, which have become a valuable biological control resource because of their advantages in producing various secondary metabolites with novel structures and remarkable biological activities. The purpose of this study was to isolate an effective antagonistic actinomycete against the pathogen of corm rot in saffron. An antagonistic actinomycete, CM253, was screened from the rhizosphere soil samples of Crocus sativus, by plate co-culture with four pathogenic fungi (Fusarium oxysporum, Fusarium solani, Penicillium citreosulfuratum, and Penicillium citrinum). CM253 inhibited the growth and development of F. oxysporum hyphae by scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Furthermore, by analyzing the degrading enzyme, the growth-promoting performance, and the whole genome of strain CM253, it was identified as Streptomyces yangpuensis, which produces NH3, protease, glucanase, cellulase, IAA, and ACC deaminase. In addition, 24 secondary metabolite synthesis gene clusters were predicted in antiSMASH. We identified genes encoding 2,3-butanediol; methionine; isoprene (metH, mmuM, ispEFH, gcpE, idi, and ilvABCDEH); biofilm formation; and colonization (upp, rfbBC, efp, aftA, pssA, pilD, fliA, and dhaM). Above all, S. yangpuensis CM253 showed the potential for future development as a biocontrol agent.
Tunable and Switchable Multi-Wavelength Erbium-Doped Fiber Laser Based on Composite Structure Filter
Authors: Shi Boya , Liu Chang , Lei Xinyan , Zhao Junfa , Yan Shuxia
Published: October 2022

A multi-wavelength erbium-doped fiber laser (MW-EDFL) with wide tuning range, switching and adjustable wavelength interval is designed and tested, which is based on a composite filter. The filter consists of a tapered microfiber coupler loop (TMCL) with a nested single mode fiber (SMF)-two mode fiber (TMF)-SMF (STS) structure, which has a comb spectrum with obvious envelope and uniform fluctuation. Our experimental and theoretical results show that the laser can output thirteen wavelengths, when the angles of two polarization controllers (PCs) in the TMCL are accurately set. Moreover, by adjusting the PCs, the tuning range of single- to sextuple-wavelength can reach about 40 nm. Six non-adjacent multi-wavelength outputs can be observed in some specific polarization states. The maximum side-mode suppression ratio (SMSR) of the output laser is 40.6 dB. Compared with other multi-wavelength EDFL, the output characteristics of the laser, such as the adjustability and flexibility of wavelength spacing and the switch-ability of wavelength number, have been improved.
Monolithic Side-Pumped Amplifier Based on an Yb-Doped Tapered-Fiber and Yielding 0.53 MW 9.3 ps Pulses
Authors: Bobkov Konstantin , Levchenko Andrey , Lipatov Denis , Guryanov Alexey , Bubnov Mikhail , Likhachev Mikhail
Published: October 2022

We demonstrated a simple design of a monolithic all-fiber side-coupled combiner for counter-pumped amplifiers that requires no special fiber processing systems for fabrication. The combiner based on a Yb-doped polarization-maintained tapered fiber with an output core diameter of 40 µm and a total length of 1.8 m exhibiting over 60% coupling efficiency of 976 nm 0.10 NA pump power was demonstrated and utilized to amplify 1064 nm 9.3 ps 1.84 MHz pulses up to 9.1 W of average power and 0.53 MW of peak power with near diffraction-limited beam quality. The demonstrated approach seems promising for further power scaling, retaining good output beam characteristics via design optimization.
Plant Therapeutics
Authors: Cheng Juei-Tang , Liu I-Min , Shen Szu-Chuan
Published: October 2022

Plants for therapeutics and the phytotherapy for disorders are the same thing in practice [...]
Method Development, Stability, and Pharmacokinetic Studies of Acyclovir-Loaded Topical Formulation in Spiked Rat Plasma
Authors: Alqahtani Safar M. , Altharawi Ali , Altamimi Mohammad A. , Alossaimi Manal A. , Mahdi Wael A. , Ramzan Mohhammad , Hussain Afzal
Published: October 2022

Acyclovir (ACV) is a synthetic acyclic nucleoside analogue active against herpes simplex virus type 1 and 2 (HSV-1 and HSV-2). The current research entails optimization, development, and validation of the sensitive, accurate, and precise high performance liquid chromatography-photo-diode array detector (HPLC-PDA) bioanalytical method for quantification of ACV in rat plasma. The central composite design (CCD) of Design Expert (quality by design tool) was employed for identification of significant attributes (flow rate and concentration of buffer), which affected the performance of the developed method. The elution of ACV was achieved by separating the XBridge C18 column and the mobile phase comprising of the potassium dihydrogen phosphate buffer (pH-6.8) and acetonitrile in a 90:10 v/v ratio pumped at a flow rate of 1.0 mL/ min. The method was validated as per International Council for Harmonization (ICH) guidelines in terms of selectivity, linearity, recovery, accuracy, and precision. The values of the lower limit of detection and the lower limit of quantification were found to be 30 and 100 ng/mL, respectively. Conclusively, the study showed superior performance with high robustness, sensitivity, and specificity of the developed bioanalytical method. The developed quantification method was applied for estimating pharmacokinetic (PK) parameters of ACV loaded vesicular systems (ethosomes, elastic liposomes, colloidal solution, and solution) transdermally applied to rat skin (using a previously published report). The method was successful in quantifying PK profiles for comparative assessment with a high robustness, re-validity, re-transferable, and simplicity approach.
Multiple Mobile Robots Coordination in Shared Workspace for Task Makespan Minimization
Authors: Rudy Jarosław , Idzikowski Radosław , Roszkowska Elzbieta , Kluwak Konrad
Published: October 2022

In this paper we consider a system of multiple mobile robots (MMRS) and the process of their concurrent motion in a shared two-dimensional workspace. The goal is to plan the robot movement along given fixed paths so as to minimize the completion time of all the robots while ensuring that they never collide. Thus, the considered problem combines the problems of robot schedule optimization with collision and deadlock avoidance. The problem formulation is presented and its equivalent reformulation that does not depend explicitly on the geometry of the robot paths is proposed. An event-based solution representation is proposed, allowing for a discrete optimization approach. Two types of possible deadlocks are identified and deadlock avoidance procedures are discussed. We proposed two types of solving methods. First, we implemented two metaheuristics: the local-search-based taboo search as well as the population-based artificial bee colony. Next, we implemented 14 simple constructive algorithms, employing dispatch rules such as first-in first-out, shortest distance remaining first, and longest distance remaining first, among others. A set of problem instances for different numbers of robots is created and provided as a benchmark. The effectiveness of the solving methods is then evaluated by simulation using the generated instances. Both deterministic and lognormal-distributed uncertain robot travel times are considered. The results prove that the taboo search metaheuristic obtained the best results for both deterministic and uncertain cases, with only artificial bee colony and a few constructive algorithms managing to remain competitive. Detailed results as well as ideas to further improve proposed methods are discussed.
Effect of Operational Variables on the Yield of Chemoenzymatic Oxidation of 2,5-Furandicarboxaldehyde to 2,5-Furandicarboxylic Acid in Fed-Batch and Continuous Packed-Bed Millibioreactor
Authors: Balboa Cristian , Schrebler Rodrigo A. , Lienqueo María Elena , Guajardo Nadia
Published: October 2022

This work explores for the first time the use of a fed-batch and continuous packed-bed millibioreactor for the chemoenzymatic oxidation of 2,5-furandicarboxaldehyde (DFF) to 2,5-furandicarboxylic acid (FDCA). Different operational variables were studied: temperature, substrate concentration, and flow rate using different reactors (batch, fed-batch, and a continuous packed-bed bioreactor). The best yield (100%) was achieved using the fed-batch reactor at an H2O2 flow rate of 3 µL/min with a substrate concentration (DFF) of 100 mM. Regarding the specific productivity, the highest values (>0.05 mg product/min g biocatalyst) were reached with the operation in the fed-batch bioreactor and the continuous packed-bed bioreactor. The yield of the biocatalyst decreased by 98% after the first reaction cycle during the operational stability tests, due to a substantial inactivation of the biocatalyst by H2O2 and peracid. In this study, it is possible to select the operational variables in fed-batch and continuous reactors for chemoenzymatic oxidation that can increase the yield and specific productivity; however, the stability of the biocatalyst should be improved in future research.
Resin-Bonded Prosthesis in Posterior Area to Prevent Early Marginal Bone Resorption in Implants Placed at Tissue Level
Authors: Prati Carlo , Zamparini Fausto , Azizi Arash , Spinelli Andrea , Gandolfi Maria Giovanna
Published: October 2022

Aim: To evaluate the effect of the resin-bonded prosthesis (Maryland bridge) on marginal bone remodeling of implants placed at the tissue level in the posterior region. Methods: Consecutive healthy patients (n = 46) were included in this clinical study. Flapless not-submerged implants were placed with cover screws exposed and positioned approximately 0.5 mm above tissue level. Patients received the implant and a temporary resin-bonded prosthesis (RBP) (n = 22) or only the implant (n = 24). The RBPs were kept in place for 3 months and removed before impressions. The implants received a custom-made abutment and provisional resin crowns followed by definitive cemented metal–ceramic crowns after 2–3 weeks. The marginal bone level (MBL) was evaluated in a single-blind condition on scanned periapical radiographs and assessed mesially and distally (MBL-M/MBL-D). The bone levels of adjacent teeth (CEJ-M/CEJ-D) and the modification of the area between the implant and the mesial/distal teeth (Area-M/Area-D) were measured. All measurements were made at 1, 3 (pre-loading time) and 12 months (post-loading time). Linear regression models were fitted to evaluate the existence of any significant difference. Results: A total of 44 patients (20 Female, 24 Male; Mean age: 53.9 ± 10.3) completed the study. Two patients were excluded for fractured RBP or de-bonding. The drop-out was of 4.3%. After 12 months, all implants were free from complications. No peri-implantitis or mucositis were observed. The RBP group showed the most stable MBL at 12 months (−0.07 ± 0.41), statistically different from the non-RBP group (−0.67 ± 0.52). CEJ-M and CEJ-D were stable in both groups. Conclusion: The proposed approach of the use of RBP creates a more stable marginal bone level around implants placed at the tissue level, resulting in a reliable technique to protect bone tissue from mechanical and occlusal trauma during the healing period and osteointegration.
How Do Theological and Secular Ethics Relate and Compare?
Authors: Langerak Edward
Published: October 2022

This article relates and compares some important features of Western religious and secular morality by way of surveying the debate over different answers to the question whether morality depends on religion in some significant way. The three main ways examined are whether morality depends on religion for an objective foundation, whether morality depends on religion for its content, and whether morality depends on religion for motivation. What emerges is that while religion can provide an objective foundation, a worthy content, and an admirable motivation for those who accept its distinctive theological claims, secularists can provide plausible, if debatable, alternatives to a theological foundation, as well as a moral content and motivation that can have interesting overlaps with those of religious ethics.
Two Regional Deployment Algorithms of Distributed GNSS Forwarding Spoofer for Multiple Receiver Sensors
Authors: Gao Yangjun , Li Guangyun
Published: October 2022

Global navigation satellite system (GNSS) spoofing technology is an effective way to protect sensitive facilities and control foreign objects. To realize effective distributed GNSS forwarding spoofing for multiple receiver sensors in the area, the following research work is carried out: first, the GNSS forwarding spoofing model is established, including a forwarding spoofing mathematical model and an asynchronous traction spoofing method; second, the function scope of forwarding spoofing is fully evaluated; third, two forwarding spoofer area deployment algorithms for multi-spoofer multi-target (MSMT) are proposed—the multi-target same-point spoofing algorithm (MSPSA) is suitable for the same-point spoofing of multiple receiver sensors, and the multi-target different-point spoofing algorithm (MDPSA) is suitable for the different-point spoofing of multiple receiver sensors; and four, the experimental tests of MSPSA and MDPSA for MSMT were carried out. The experimental results show that MSPSA and MDPSA can respectively give the most appropriate deployment scheme of spoofing according to the various needs of the spoofer. For example, the number of spoofing devices is 1, the total distance between each spoofer and each receiver is 40,345.1 m, and the critical spoofing rate (CSR) and spoofing success rate (SSR) are both 100%. The performance of the spoofing deployment scheme can meet the needs of the spoofer.
An Effective Method to Model and Simulate the Behavior of Inductive Angle Encoders
Authors: Dauth Robert Alexander , Gerlach Gerald , Fella Sina
Published: October 2022

Many angle or position sensors rank among the inductive encoders, although their sensing principle is different. The sensor design investigated in this paper is based on coupled coils, whereas the information about the position angle is modulated on the induced voltage, measured at the receiving coils. Unfortunately, no closed solution for most of the physical quantities exists, since this principle is based on eddy currents, which are rather complex to calculate for the given geometry. Consequently, the common way is to calculate the sensor quantities by a 3D finite-element (FE) simulation. However, this leads in most cases to a high time and computational effort. To overcome the limitations with respect to computational resources, a novel method is presented to reduce simulation effort and calculate regression models, which can even replace simulations. In the following investigations, D-optimal designs are used—a subdomain in the field of statistical design of experiments—and combined with a numerical implementation of Faraday’s law, in order to calculate the induced voltages afterwards from simulated magnetic field data. With this method, the sensor signals can be calculated for multiple angle positions from one simulated position by shifting the integration boundaries. Hence, simulation time is significantly reduced for a full period. The regression models obtained by this method, can predict the Tx-coil inductance, induced Rx-voltage amplitude and angular error in dependency of geometric design parameters.
A Method for Extracting Debye Parameters as a Tool for Monitoring Watered and Contaminated Soils
Authors: Cataldo Andrea , Farhat Iman , Farrugia Lourdes , Persico Raffaele , Schiavoni Raissa
Published: October 2022

Soil monitoring is a key topic from several perspectives, such as moisture level control for irrigation management and anti-contamination purposes. Monitoring the latter is becoming even more important due to increasing environmental pollution. As a direct consequence, there is a strong demand for innovative monitoring systems that are low cost, provide for quasi-real time and in situ monitoring, high sensitivity, and adequate accuracy. Starting from these considerations, this paper addresses the implementation of a microwave reflectometry based-system utilizing a customized bifilar probe and a miniaturized Vector Network Analyzer (m-VNA). The main objective is to relate frequency-domain (FD) measurements to the features of interest, such as the water content and/or the percentage of some polluting substances, through an innovative automatable procedure to retrieve the Debye dielectric parameters of the soil under different conditions. The results from this study confirm the potential of microwave reflectometry for moisture monitoring and contamination detection.
Development of an Obesity Information Diagnosis Model Reflecting Body Type Information Using 3D Body Information Values
Authors: Kim Changgyun , Youm Sekyoung
Published: October 2022

This study uses various body values (length, circumference, and volume) that can be derived from 3D data to determine variables and areas that substantially affect obesity and suggests guidelines for diagnosing obesity that are more elaborate than existing obesity indices. Body data for 170 participants (87 men and 73 women aged 20–30 years) are collected for the chest, abdomen, hips, and arms/legs. A 3D scanner, which can produce accurate body point results, and dual-energy X-ray (DEXA), which can accurately determine the fat percentage, are used to derive fat rates for each body part. The fat percentage and total fat percentage for each body part are used as learning data. For the derived data, the eigenvalue for each body part is derived using a principal component analysis, and the following four clusters are created for each part: underweight, normal, overweight, and obese. A comparison with the obesity index, which diagnoses obesity based on the cluster model, showed that the accuracy of the model proposed in this study is higher at 80%. Therefore, this model can determine the body information necessary for accurate obesity diagnosis and be used to diagnose obesity with greater accuracy than obesity indices without a body fat measurement machine such as DEXA.
MIMO Antennas: Design Approaches, Techniques and Applications
Authors: Sharma Preeti , Tiwari Rakesh N. , Singh Prabhakar , Kumar Pradeep , Kanaujia Binod K.
Published: October 2022

The excessive use of digital platforms with rapidly increasing users in the wireless domain enforces communication systems to provide information with high data rates, high reliability and strong transmission connection quality. Wireless systems with single antenna elements are not able to accomplish the desired needs. Therefore, multiple-input multiple-output (MIMO) antennas are getting more attention in modern high-speed communication systems and play an essential part in the current generation of wireless technology. However, along with their ability to significantly increase channel capacity, it is a challenge to achieve an optimal isolation in a compact size for fifth-generation (5G) terminals. Portable devices, automobiles, handheld gadgets, smart phones, wireless sensors, radio frequency identification and other applications use MIMO antenna systems. In this review paper, the fundamentals of MIMO antennas, the performance parameters of MIMO antennas, and different design approaches and methodologies are discussed to realize the three most commonly used MIMO antennas, i.e., ultra-wideband (UWB), dual-band and circularly polarized antennas. The recent MIMO antenna design approaches with UWB, dual band and circularly polarized characteristics are compared in terms of their isolation techniques, gain, efficiency, envelope correlation coefficient (ECC) and channel capacity loss (CCL). This paper is very helpful to design suitable MIMO antennas applicable in UWB systems, satellite communication systems, GSM, Bluetooth, WiMAX, WLAN and many more. The issues with MIMO antenna systems in the indoor environment along with possible solutions to improve their performance are discussed. The paper also focuses on the applications of MIMO characteristics for future sixth-generation (6G) technology.
Optimal PID Control of a Brushed DC Motor with an Embedded Low-Cost Magnetic Quadrature Encoder for Improved Step Overshoot and Undershoot Responses in a Mobile Robot Application
Authors: Bitriá Ricard , Palacín Jordi
Published: October 2022

The development of a proportional–integral–derivative (PID) control system is a simple, practical, highly effective method used to control the angular rotational velocity of electric motors. This paper describes the optimization of the PID control of a brushed DC motor (BDCM) with an embedded low-cost magnetic quadrature encoder. This paper demonstrates empirically that the feedback provided by low-cost magnetic encoders produces some inaccuracies and control artifacts that are not usually considered in simulations, proposing a practical optimization approach in order to improve the step overshoot and undershoot controller response. This optimization approach is responsible for the motion performances of a human-sized omnidirectional mobile robot using three motorized omnidirectional wheels.
Trust-Aware Routing Mechanism through an Edge Node for IoT-Enabled Sensor Networks
Authors: Saleh Alaa , Joshi Pallavi , Rathore Rajkumar Singh , Sengar Sandeep Singh
Published: October 2022

Although IoT technology is advanced, wireless systems are prone to faults and attacks. The replaying information about routing in the case of multi-hop routing has led to the problem of identity deception among nodes. The devastating attacks against the routing protocols as well as harsh network conditions make the situation even worse. Although most of the research in the literature aim at making the IoT system more trustworthy and ensuring faultlessness, it is still a challenging task. Motivated by this, the present proposal introduces a trust-aware routing mechanism (TARM), which uses an edge node with mobility feature that can collect data from faultless nodes. The edge node works based on a trust evaluation method, which segregates the faulty and anomalous nodes from normal nodes. In TARM, a modified gray wolf optimization (GWO) is used for forming the clusters out of the deployed sensor nodes. Once the clusters are formed, each cluster’s trust values are calculated, and the edge node starts collecting data only from trustworthy nodes via the respective cluster heads. The artificial bee colony optimization algorithm executes the optimal routing path from the trustworthy nodes to the mobile edge node. The simulations show that the proposed method exhibits around a 58% hike in trustworthiness, ensuring the high security offered by the proposed trust evaluation scheme when validated with other similar approaches. It also shows a detection rate of 96.7% in detecting untrustworthy nodes. Additionally, the accuracy of the proposed method reaches 91.96%, which is recorded to be the highest among the similar latest schemes. The performance of the proposed approach has proved that it has overcome many weaknesses of previous similar techniques with low cost and mitigated complexity.
Frequency-Modulated Signal Measurement Using Closed-Loop Methodology
Authors: Sun Xinglin , Wu Haojie , Tan Xinyue , Wang Wenrui , Ye Lingyun , Song Kaichen
Published: October 2022

Frequency-modulated (FM) signals are widely used in sensing, measurement, and signal detection due to their strong anti-interference and easy transmission characteristics. Although the high-precision measurement methods for static signals are quite complete, the high-precision measurement methods for dynamic FM signals still need to be studied, and the measurement accuracy in the high-sampling system still has room for improvement. Traditionally, the equal-precision measurement method is widely applied in most scenarios. However, its accuracy is limited by the quantization error of ±1 word and the sampling gate time, making it difficult to improve the frequency measurement accuracy while ensuring a high sampling rate at the same time. In this paper, a high-precision feedback frequency measurement system with the capability to eliminate the quantization error of ±1 word is proposed. The proposed system consists of two stages, the rough measurement stage based on the equal-precision measurement method and the precise measurement stage based on the negative feedback tracking architecture using the phase–frequency detector (PFD) and direct digital synthesizer (DDS). The effectiveness and feasibility of the system are verified by both simulation and experiment. At the sampling rate of 2 kHz, the frequency measurement accuracy is improved by more than 30 dB.
Wind Resistance Mechanism of an Anole Lizard-Inspired Climbing Robot
Authors: Li Rui , Feng Shenyao , Yan Shuang , Liu Xiao , Yang Ping-An , Yang Xingyi , Shou Mengjie , Yu Zhangguo
Published: October 2022

The stable operation of climbing robots exposed to high winds is of great significance for the health-monitoring of structures. This study proposes an anole lizard-like climbing robot inspired by its superior wind resistance. First, the stability mechanism of the anole lizard body in adhesion and desorption is investigated by developing adhesion and desorption models, respectively. Then, the hypothesis that the anole lizard improves its adhesion and stability performance through abdominal adjustment and trunk swing is tested by developing a simplified body model and kinematic model. After that, the structures of the toe, limb, and multi-stage flexible torso of the anole lizard-like climbing robot are designed. Subsequently, the aerodynamic behavior of the proposed robot under high-speed airflow are investigated using finite element analysis. The results show that when there is no obstacle, the climbing robot generates the normal force to enhance toepad friction and adhesion by tuning the abdomen’s shape to create an air pressure difference between the back and abdomen. When there is an obstacle, a component force is obtained through periodic oscillation of the spine and tail to resist the frontal winds resulting from the vortex paths generated by the airflow behind the obstacle. These results confirm that the proposed hypothesis is correct. Finally, the adhesion and wind resistance performance of the anole lizard-like climbing robot is tested through the developed experimental platform. It is found that the adhesion force is equal to 50 N when the pre-pressure is 20 N. Further, it is shown that the normal pressure of the proposed robot can reach 76.6% of its weight in a high wind of 14 m/s.
Design and Calibration of Plane Mirror Setups for Mobile Robots with a 2D-Lidar
Authors: Kibii James E. , Dreher Andreas , Wormser Paul L. , Gimpel Hartmut
Published: October 2022

Lidar sensors are widely used for environmental perception on autonomous robot vehicles (ARV). The field of view (FOV) of Lidar sensors can be reshaped by positioning plane mirrors in their vicinity. Mirror setups can especially improve the FOV for ground detection of ARVs with 2D-Lidar sensors. This paper presents an overview of several geometric designs and their strengths for certain vehicle types. Additionally, a new and easy-to-implement calibration procedure for setups of 2D-Lidar sensors with mirrors is presented to determine precise mirror orientations and positions, using a single flat calibration object with a pre-aligned simple fiducial marker. Measurement data from a prototype vehicle with a 2D-Lidar with a 2 m range using this new calibration procedure are presented. We show that the calibrated mirror orientations are accurate to less than 0.6° in this short range, which is a significant improvement over the orientation angles taken directly from the CAD. The accuracy of the point cloud data improved, and no significant decrease in distance noise was introduced. We deduced general guidelines for successful calibration setups using our method. In conclusion, a 2D-Lidar sensor and two plane mirrors calibrated with this method are a cost-effective and accurate way for robot engineers to improve the environmental perception of ARVs.
Cooperative DF Protocol for MIMO Systems Using One-Bit ADCs
Authors: Kim Tae-Kyoung
Published: October 2022

This study considers a detection scheme for cooperative multi-input–multi-output (MIMO) systems using one-bit analog-to-digital converters (ADCs) in a decode-and-forward (DF) relay protocol. The use of one-bit ADCs is a promising technique for reducing the power consumption, which is necessary for supporting future wireless systems comprising a large number of antennas. However, the use of a large number of antennas remains still limited to mobile devices owing to their size. Cooperative communication using a DF relay can resolve this limitation; however, detection errors at the relay make it difficult to employ cooperative communication directly. This difficulty is more severe in a MIMO system using one-bit ADCs due to its nonlinear nature. To efficiently address the difficulty, this paper proposes a detection scheme that mitigates the error propagation effect. The upper bound of the pairwise error probability (PEP) of one-bit ADCs is first derived in a weighted Hamming distance form. Then, using the derived PEP, the proposed detection for the DF relay protocol is derived as a single weighted Hamming distance. Finally, the complexity of the proposed detection is analyzed in terms of real multiplications. The simulation results show that the proposed detection method efficiently mitigates the error propagation effect but has a relatively low level of complexity when compared to conventional detection methods.
A Formal Performance Evaluation Method for Customised Plug-and-Play Manufacturing Systems Using Coloured Petri Nets
Authors: Wang Ge , Li Di , Wang Shiyong , Cheng Minghao , Luo Ziren , Liu Renshun
Published: October 2022

Recent technological advancements and the evolution of industrial manufacturing paradigms have substantially increased the complexity of product-specific production systems. To reduce the time cost of modelling and verification and to enhance the degree of uniformity in the modelling process of system components, this article presents a componentised framework for domain modelling and performance analysis based on the concept of “multi-granularity and multi-view” for a production line of personalised and customised products, for plug-and-play manufacturing processes to involving a large number of model input parameters. The coloured Petri net tool is utilised as a simulation tool for mapping domain models to computational models for simulation and performance evaluation. This paper presents a method for setting the input parameters of a production system when using WIP, through-put and cycle time as metrics. The results of the performance analysis demonstrate the applicability of the proposed framework and provide direction for the production line’s layout design and scheduling strategy.
Improvement in the Tracking Performance of a Maneuvering Target in the Presence of Clutter
Authors: Shah Ghawas Ali , Khan Sumair , Memon Sufyan Ali , Shahzad Mohsin , Mahmood Zahid , Khan Uzair
Published: October 2022

The proposed work uses fixed lag smoothing on the interactive multiple model-integrated probabilistic data association algorithm (IMM-IPDA) to enhance its performance. This approach makes use of the advantages of the fixed lag smoothing algorithm to track the motion of a maneuvering target while it is surrounded by clutter. The suggested method provides a new mathematical foundation in terms of smoothing for mode probabilities in addition to the target trajectory state and target existence state by including the smoothing advantages. The suggested fixed lag smoothing IMM-IPDA (FLs IMM-IPDA) method’s root mean square error (RMSE), true track rate (TTR), and mode probabilities are compared to those of other recent algorithms in the literature in this study. The results clearly show that the proposed algorithm outperformed the already-known methods in the literature in terms of these above parameters of interest.