bluuebunny/crossref_metadata_2025 huggingface dataset:
Oxidative stress and exogenous constitutional obesity
Authors: Silizertseva O. A. , Darenskaya M. A. , Rychkova L. V. , Gutnik I. N. , Astakhova T. A. , Kolesnikova L. I.
Published: January 2025

The literature review is devoted to the problem of exogenous-constitutional obesity and the role of oxidative stress (OS) in this form of obesity. The issues of modern diagnostics and pathogenesis of exogenous-constitutional obesity are considered. The results of various studies devoted to the study of OS in obesity in both laboratory animals and humans are presented. Excess body weight is often accompanied by increased OS and subclinical systemic inflammation. The need to correct the antioxidant status of the body is a topical issue, an important part of which is an individual approach to the selection of agents and dosages in order to reduce the negative impact of free radicals at the cellular level. A significant problem is the lack of a single standard for determining OS parameters, which requires standardized laboratory equipment, in this regard, the choice of a specific method is a responsible step for a research specialist. In this area, there are still many questions that require more detailed study.
Comparison of the effects of three glyprolines after five days of intraperitoneal administration
Authors: Kolesnikova A. A. , Fleishman M. Yu. , Malofey Yu. B. , Tolstenok I. V. , Duzenko N. V. , Salnikov A. A.
Published: January 2025

To date, about 70 drugs based on regulatory peptides have been registered, including proline-containing ones, such as the nootropics Semax and Selank. Further study of the properties of glyproline peptide sequences is relevant in order to describe their neuroprotective properties and the possible development of new drugs based on them. The purpose of the study was to compare the effects of three glyproline peptides on the morphometric characteristics and proliferative activity of brain cells in albino rats. Material and methods. Sexually mature Wistar male rats were intraperitoneally injected with the peptides Thy-Lys-Pro-Arg-Pro-Gly-Pro (TKPRPGP), Arg-Pro-Gly-Pro (RPGP) and Pro-Gly-Pro-Leu (PGPL) at a dose of 0.1 mg/kg for 5 days. The intact animals that received 0.9 % sodium chloride solution in equivolume served as controls. Morphocytometry was performed on preparations of the right hemisphere of the brain after staining with hematoxylin and eosin. The dimensional (area of bodies, nuclei, and nucleoli) and numerical (number of nucleoli) characteristics of cells were assessed. We examined the parameters of neurons and gliocytes in five localizations (the second and fifth layers of the anterior parietal lobe, the second and fifth layers of the proprietal lobe, field CA1 of the hippocampus). Using immunohistochemical staining, the proliferation intensity was determined (marker Ki-67, clone MIB1). Results. The TKPRPGP peptide changed the morphometric parameters of nervous tissue cells and the gliocyte proliferation index to a greater extent than RPGP and PGPL. In our experiment, the proliferative activity of neurons is maximally influenced by glyproline PGPL. The arginine-containing compound RPGP activates the proliferative activity of gliocytes. Leucine-containing PGPL, to a greater extent, changes the morphometric parameters of neurons. Conclusions. Both studied tetrapeptides affect the morphometric characteristics and proliferative activity of nervous tissue cells when administered five times intraperitoneally at a dose of 0.1 mg/kg. When comparing glyprolines, a more pronounced effect was observed after the administration of PGPL.
Wound healing properties of a chimeric form of human GM-CSF in a rat burn injury model
Authors: Pykhtina M. B. , Miroshnichenko S. M. , Karpov M. A. , Abyshev A. A. , Mosalev K. I. , Kotova M. V. , Beklemishev A. A. , Knyazev R. A.
Published: January 2025

Thermal burns are one of the common types of human injuries, causing in severe cases an extensive immune response both locally in the wound and having a systemic effect. The search for new means of local treatment of burn wounds remains an urgent task. The aim of this study was to investigate the wound healing properties of recombinant granulocyte-macrophage colony-stimulating factor (ryGM-CSF) and its prolonged chimeric form with human apolipoprotein AI (ryGM-CSF-apoAI) on the model of burn injury in rats. Material and methods. ryGM-CSF and ryGM-CSF-apoAI obtained by expression in yeast P. pastoris were used in this work. The study was performed on 27 Wistar rats, which were modeled burns of III degree. The wound-healing effect of recombinant cytokines was evaluated morphologically, and the expression of cytokine genes - markers of the course of the wound process and angiogenesis - was measured. Results and discussion. ryGM-CSF is known to accelerate wound healing. Human rGM-CSF on the rat burn model showed both the properties of a cytokine influencing angiogenesis, increasing the number of vessels, and being a foreign protein stimulated the immune response, increasing prolonged the number of lymphocytes and supporting inflammation. The chimeric form of cytokine ryGM-CSF-apoAI reduced inflammation, accelerated the change of wound healing phases and, as a consequence, reduced the number of neutrophils by 16 days. Unexpectedly, it induced maturation of vessels, which in this case had normal lumen, size, and were lined with endothelium. The ratio Angpt1 and Angpt2 gene mRNA content was 2-fold higher when ryGM-CSF-apoAI was used, compared to control and ryGM-CSF administration. Conclusions. With xenogeneous administration, recombinant human GM-CSF prolongs inflammation due to early lymphocytic response to foreign protein and increased neutrophil content at later wound healing periods. The chimeric form ryGM-CSF-apoAI reduces cytokine immunogenicity by promoting earlier replacement of neutrophils by macrophages and fibroblasts and stimulates maturation of high-grade blood vessels.
Improvement of antioxidant protection and energy production in neurodegenerative processes in the brain caused by long-term alcoholism under the influence of Lophantus chinensis Benth extract
Authors: Toropova A. A. , Razuvaeva Ya. G. , Khaltagarova E. D. , Olennikov D. N.
Published: January 2025

Long-term alcohol abuse causes psycho-emotional and cognitive impairment, including severe dementia. Oxidative stress is considered one of the main mechanisms in the cognitive disorders pathophysiology caused by long-term alcoholism. In this regard, the search for substances capable of correcting mitochondrial dysfunction and oxidative stress that arise as a result of prolonged ethanol consumption is relevant. Of particular interest in the complex treatment of alcoholic encephalopathy is Chinese hyssop (Lophanthus chinensis), used in Tibetan and Mongolian traditional medicine for liver diseases, as well as a means of improving the functional state of the body and metabolism, slowing down the aging process. Material and methods. Alcohol intoxication was modeled in Wistar rats by per os administration of a 40 % ethanol solution in a volume of 10 ml/kg for six weeks. The L. chinensis dry extract at a dose of 100 mg/kg was administered to animals per os starting from the third week, an hour after ethanol. On day 45, the content of malondialdehyde (MDA), reduced glutathione (GSH), activity of catalase, superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase, NADH dehydrogenase and succinate dehydrogenase complex, concentration of ATP werei determined spectrophotometrically in the animal brain homogenate. Results. It was found that L. chinensis extract increases the activity of catalase, superoxide dismutase, glutathione peroxidase, glutathione reductase (by 10 %, р = 0.016, by 31 %, р = 0.001, by 30 %, р = 0.041, by 29 %, р = 0.009, respectively) and GSH content (by 24 %, р = 0.019), and also reduces the concentration of MDA (by 20 %, р = 0.014) in brain tissue. A decrease in the intensity of oxidative stress enhances the functioning of enzymatic complexes I (by 23 %, р = 0.017) and II of the mitochondrial respiratory chain (by 72 %, р = 0.001) and increases the ATP content (by 23 %, р = 0.029) in the rat’s brain. Conclusions. L. chinensis extract exhibits antioxidant effects and stimulates energy processes in neurodegenerative processes in the brain caused by long-term alcoholism.
Risk assessment of hypertensive and metabolic disorders in pregnant women with COVID-19
Authors: Zhukovets I. V. , Andrievskaya I. A. , Krivoshchekova N. A. , Narkevich A. N. , Ustinov E. M.
Published: January 2025

According to international research data, COVID-19 increases the risk of developing hypertensive and metabolic disorders. Aim of the study was to assess the risks of hypertensive and metabolic disorders in pregnant women with COVID-19 and to identify potential markers of these conditions. Material and methods. The study involved 265 pregnant women, infected in the first, second, and third trimesters of pregnancy, and uninfected with COVID-19, from 2020 to 2022. Spectrophotometric methods were used to evaluate blood level of glucose, total cholesterol, high- and low-density lipoprotein (LDL), and triglycerides. ELISA was used to measure content of oxidized LDL and apolipoprotein B (apo B). Results. Gestational arterial hypertension (GAH) developed more frequently in women with COVID-19 infected in the second trimester compared to those infected in the third trimester (15.7 and 6.1 % cases, respectively, p = 0.044). Gestational diabetes mellitus (GDM) was more commonly diagnosed in pregnant women with COVID-19 than in those uninfected (17.2 and 4.0 % cases, respectively, p = 0.015), particularly in those infected in the second and third trimesters (17.6 and 18.9 %, respectively). Pregnant women with COVID-19 showed an increase in glucose levels by 1.14 times (p = 0.001), oxidized LDL by 1.24 times (p = 0.042), and apo B protein by 1.14 times (p = 0.025) in blood serum. Conclusions. Infection with COVID-19 in the second trimester of pregnancy increases the risk of GAH by 2.56 times, and in the second and third trimesters, the risk of GDM by 4.3 times. Increase of glucose, oxidized LDL, and apo B content in blood serum may have prognostic significance in the development of hypertensive disorders.
Incidence of atrioventricular conduction disturbances and need for pacemaker implantation in patients after endovascular aortic valve replacement
Authors: Stolbikov Yu. Yu. , Matyushin G. V. , Protopopov A. V. , Samokhvalov E. V. , Ishchenko O. P. , Kobanenko V. O.
Published: January 2025

The aim of the study was to evaluate predictors of cardiac conduction disturbance associated with increased risk of temporary and permanent pacemaker implantation after endovascular aortic valve replacement (TAVR). Material and methods. We analyzed patients who underwent surgical treatment for aortic valve replacement by endovascular treatment in Krasnoyarsk Regional Clinical Hospital from January 2018 to May 2023. The total number of people included in the study is 157. Results and discussion. The association between the occurrence of atrioventricular block of II–III degree, left bundle branch block and atrial fibrillation after TAVR implantation, which required temporary pacemaker implantation and permanent pacemaker implantation, was revealed. Atrioventricular block of grade II-III was first detected in 11 (13.3 %) patients after TAVR, left bundle branch block – in 22 (26.5 %) and atrial fibrillation – in 11 (13.3 %). The need for temporary pacing during TAVR was necessary in 35 (23.6 %) patients. 34 (23.0 %) patients had a temporary pacemaker placed within the first 2 days after surgical intervention and 1 patient (0.7 %) after 3 days. Regression analysis revealed 6 significant risk factors for temporary pacemaker implantation: left bundle branch block (p = 0.002), atrial fibrillation (p = 0.030), 1st degree atrioventricular block (p = 0.032), age (p = 0.012), female gender (p = 0.033) and history of acute myocardial infarction (p = 0.024). Permanent pacemaker implantation was performed in 7 (4.5 %) patients in the period from 4 to 20 days, including 6 (85.7 %) patients due to complete atrioventricular block and 1 (14.3 %) patient due to sinus node dysfunction. Permanent pacemaker was implanted to five (3.2 %) patients in the period from 6 months to 3.6 years, including 3 (1.9 %) patients due to complete atrioventricular block and 2 (1.3 %) patients due to sinus node dysfunction. Regression analysis revealed 2 significant risk factors for permanent pacemaker implantation: presence of atrial fibrillation before surgical intervention (p = 0.002; r = 0.160) and presence of left bundle branch block before TAVR (p = 0.037; r = 0.108). Conclusions. Identification of predictors of atrioventricular block of II–III degrees after TAVR will facilitate timely temporary pacing and permanent pacemaker implantation to prevent complications due to bradyarrhythmias.
Causes of unsatisfactory quality of follow-up of patients with arterial hypertension by district therapists
Authors: Manoilov A. E. , Markina A. Yu. , Malykhina O. P.
Published: January 2025

Factors affecting the quality of follow-up (FU) of patients with arterial hypertension (AH) have been evaluated in several large-scale studies by Russian scientists. It was found that the indicators of the process and results of medical care for dispensary patients with AH often did not correspond to the conventional benchmark indicators. The purpose of the study was to identify structure, process, and performance indicators that negatively affect the quality of physician FU of AH patients. Material and methods. The study was performed according to the results of 2022. The level of knowledge of doctors, the scheme of the electronic outpatient card, and equipment for ultrasound diagnostics were studied as structural parameters. To assess the process characteristics, information on home blood pressure (BP) monitoring, patients’ adherence to treatment, availability of current analysis of the FU process were used. Performance indicators included information on normalization of BP and lipid level during the year, about stabilization, regression of the degree of left ventricular hypertrophy and carotid atherosclerosis. The sample of respondents, outpatient records was formed by random method. Results. 58.3 % of respondents were not informed about the possibilities of drug therapy to prevent the damaging effect of AH on target organs. The electronic outpatient cards lacked the templates “Follow-up”, “Stage discharge summary”. The available medical equipment met the needs of FUs by about 50 %. Information on home BP monitoring and patients’ adherence to therapy was available in 8.0 % of cases. Current summarization of FU was performed in 10.0 % of patients, assessment of lipid content dynamics, degree of left ventricular hypertrophy and carotid atherosclerosis was not performed in any case. Data on normalization of BP and lipid levels, data on stabilization, regression of left ventricular hypertrophy and carotid atherosclerosis during a year were actually absent. Conclusions. The identified indicators of structure, process and performance of DN are a probable cause of unsatisfactory quality of physician follow-up of AH patients.
Contra o Estado laico: a condenação da liberdade religiosa pelo Centro Dom Bosco através do curso “Catecismo da Crise da Igreja”
Authors: Arruda Thiago
Published: January 2025

O objetivo deste artigo é investigar a fundamentação do discurso contrário à laicidade do Estado produzido pelo Centro Dom Bosco, associação leiga ligada ao tradicionalismo católico no Brasil, através do curso “Catecismo da Crise na Igreja”. Realiza-se essa pesquisa mediante análise bibliográfica e documental. A análise bibliográfica é direcionada aos temas do tradicionalismo católico e do fundamentalismo religioso. A análise documental passa pelo exame de documentos eletrônicos escritos, documentos eclesiásticos e documentos audiovisuais, com ênfase na aula “O erro da liberdade religiosa”, uma fração do curso “Catecismo da Crise na Igreja”, produzido pelo Centro Dom Bosco. O estudo aponta que o Centro Dom Bosco combate a laicidade do Estado a partir da compreensão da liberdade religiosa como um erro e da doutrina segundo a qual o erro não tem direitos. Ao mesmo tempo, defende a instituição de um Estado Católico, capaz de proibir o culto público e a propaganda de outras religiões e de cercar a população visando à salvação das almas.
Estrela Missionária Solitária: o conservadorismo messiânico do padre Valdir Ros na diocese de Nova Iguaçu
Authors: Lira Ronald Apolinario de
Published: January 2025

O artigo pretende abordar os conflitos entre o catolicismo conservador e a Teologia da Libertação pela posse de capital religioso entre 1982 e 1994, através da figura de Valdir Ros, reitor do Instituto Estrela Missionária na Diocese de Nova Iguaçu, periferia do estado do Rio de Janeiro. Na microanálise da trajetória do padre que decidiu declarar guerra ao bispo Dom Adriano Hypólito e sua linha pastoral, governando uma paróquia cismática e autônoma por doze anos, trazendo de volta práticas pré-conciliares, poderemos compreender as dinâmicas mais amplas do catolicismo brasileiro do período posterior ao Concílio vaticano II e a luta complexa dentro do campo católico pelo novo formato de Igreja.
Historia statusu prawnego języka ukraińskiego. Od Rusi Kijowskiej do współczesnej Ukrainy
Authors: Hebisz Maria Eleonora , Stanisławski Jacek
Published: January 2025

Niepewność wynikająca z rosyjskiej inwazji na Ukrainę oznacza, że polityczna przyszłość kraju wciąż się kształtuje. Obecnie rozstrzygane są liczne aspekty dalszego funkcjonowania kraju. Dotyczy to również języka ukraińskiego, który ma znaczną liczbę rodzimych użytkowników, których nie można uznać za nawet zdalnie zagrożony, a mimo to jego przyszły status jako głównego języka instytucji państwowych jest stale zagrożony.
Jeśli przyjrzymy się burzliwej historii Ukrainy, możemy zauważyć, że nie jest to wcale nowy problem. Przez wieki ziemie ukraińskie były kontrolowane przez wiele krajów. Należały do nich Rzeczpospolita Obojga Narodów, Austro-Węgry, Czechosłowacja, Rumunia, Imperium Rosyjskie i Związek Radziecki. Wszystkie one prowadziły różną politykę wobec narodu ukraińskiego, jak również jego języka. Ponadto polityka ta była stale zmieniana. Niniejszy artykuł ma na celu przedstawienie ewolucji języka ukraińskiego, w szczególności jego statusu prawnego w podmiotach kontrolujących terytoria ukraińskie. Oprócz wyżej wymienionych unii i imperiów, wyjaśniono również status języka, jaki istniał w protopaństwowych próbach utworzenia niepodległej Ukrainy w przeszłości, takich jak Ruś Kijowska, Sicz Zaporoska, URL, ZURL i Ukraińska SRR.
Szczególny nacisk położono na historię współczesną, a mianowicie rozwój praw językowych w Związku Radzieckim i niepodległej Ukrainie. To, czy Ukraina stanie się de jure i de facto jednojęzyczną europejską demokracją, zależy od następstw aktualnie trwających wydarzeń.
Linguistic functions and indirect speech acts in tobacco products health warnings
Authors: Koszmider Julia
Published: January 2025

The study incorporates the theory of linguistic functions (Jakobson 1960) and speech act theory (Austin 1962) to analyse the differences and similarities of the language used to produce health warning signs on tobacco-related products in Polish and English. The analysis is based on the premise that labels have a primary force of being a warning, when their social function is in focus. The texts proposed as health warnings are highly formulaic and despite the fact that they address a variety of issues, they seem to be inherently similar in form. This pilot study aims to analyse corpora of selected Polish and English health warnings in order to assess the level of their linguistic similarity.
Creativity in Meaning Construction and Translation – A Cognitive Perspective on the Humurous Language Used by Big Friendly Giant in Roald Dahl’s the BFG in its English, Polish and Portuguese Versions
Authors: Klos Sylwia
Published: January 2025

The paper explains how our mind creates a meaning in a wordplay. The model of mental maps (Author, 2020) based on the theory of conceptual blending (Fauconnier,1997, Fauconnier & Turner, 2002) and the geneplore model based on the theory of creative cognition (Finke, et al, 1992) presented in the paper describe the operations in the mind related to generating, exploring and transforming ideas and/or linguistic and non-linguistic units that result in the emergence of a new meaning embedded in the wordplay. To illustrate the cognitive processes in meaning construction, the paper refers to the humorous language of Big Friendly Giant in Roald Dahl’s The BFG in its original English version as well as its translations into Polish and Portuguese.
Chunking a Transcription of a Lecture to Help Students at EAP Courses Improve their Listening Comprehension Skill(S)
Authors: Badio Janusz
Published: January 2025

Pre-sessional EAP courses in the UK welcome international students seeking admission to British universities. The official requirement for English language proficiency is typically determined by a student’s scores in the four language skills. Students' proficiency levels in these skills generally range from 5.0 to 6.5. One significant challenge faced by foreign students is in the area of listening skills. The listening comprehension classes often involve listening to lengthy lectures, during which students struggle with note-taking and answering questions. One effective instructional strategy is to provide plain text transcripts of recorded lectures. This article aims to illustrate how a lecturer segments speech and how teachers can transcribe this process and its constituent units using methodologies discussed in works such as Badio (2004), Chafe (1994, 2003), and Croft (1995). The unit of speech in these analyses is defined by a set of conceptual and phonetic criteria, and segmenting a lecture involves applying these criteria impressionistically. The resulting modified format of a plain text transcript can serve as a valuable pedagogical tool. Teachers can demonstrate to students, who may not have a background in linguistics, that a single word is not the only or primary unit of speech. They can illustrate how pauses signal new topics or how different types of intonation units are used to convey conceptualisations and regulate the flow of ideas and speech. Such focused and structured presentations enhance language acquisition and learning.
Reconsidering the Reliance on Functional Load: The Role of Phonetic Distance in Predicting L2 Segmental Substitutions
Authors: Challis Kate , Zawadzki Zoë , Kusz Ewa
Published: January 2025

Much research agrees that Functional Load (FL), i.e., the extent to which a phoneme pair distinguishes between different words in a language, is a useful feature to consider in prioritizing phoneme pairs for pronunciation instruction in the second language (L2) classroom. However, FL measures are not always easy to access and are often calculated according to different principles, whereas other more easily observable features exist, including Phonetic Distance (PD), or the degree of physiological similarity between phones in a phoneme pair. One way to evaluate features and their interrelatedness is to use them in a linear mixed effects regression (LMER) model to predict the rate of observed L2 substitutions that are actually made in speech. This study examines the relationship between two measures of FL (Brown, 1988; Gilner & Morales, 2010) and an estimate of PD we devised from 22 unique articulatory features of vowels and consonants in their ability to predict substitutions in the L2-ARCTIC dataset (Zhao et al. 2018) while accounting for other sources of variation. It was found that even when PD had a resolution of only 2 points, it was highly associated with variance in substitution rates, but that the best model included FL and PD measures together. This finding suggests that PD may also be an important consideration when deciding which phoneme pairs to prioritize in L2 instruction.
The role of cortisol in etiology and treatment of bruxism – a literature review
Authors: Galińska Wiktoria , Burliga Ilona , Moskała Monika , Baron Stefan
Published: January 2025

Celem badania była analiza roli kortyzolu zarówno w leczeniu, jak i etiologii bruksizmu. Przeprowadzono przegląd piśmiennictwa dostępnego w bazach danych PubMed oraz Embase, opublikowanego w okresie od listopada 2013 r. do listopada 2023 r. bez ograniczeń językowych. W pierwszej kolejności przeprowadzono ocenę tytułów oraz abstraktów, a następnie dokonano selekcji na podstawie całych artykułów. Do analizy włączono badania obserwacyjne oraz randomizowane kontrolowane badania kliniczne, które oceniały związek między zdiagnozowanym bruksizmem a poziomem kortyzolu w ślinie. Przeprowadzono ocenę jakości metodologicznej badań i ekstrakcję danych. Finalnie do przeglądu włączono osiem artykułów. Analiza wykazała znaczącą korelację między wyższymi stężeniami kortyzolu a występowaniem bruksizmu. Ponadto u osób z bruksizmem stężenie kortyzolu przed rozpoczęciem leczenia było wyższe niż po jego zakończeniu.
Documentation analytique. A propos d'un ouvrage récent : « HALL (J. M.) et SWAINE (M. D.). Distribution et écologie des plantes vasculaires dans une forêt tropicale humide. Formation végétale au Ghana »
Authors: Letouzey R.
Published: January 2025

Pas de résumé
Tired of the double burden? The impact of work-to-family and family-to-work conflict on sleep duration
Authors: Maciejewski Linda , Tuppat Julia
Published: January 2025

Objective: This study examines the impact of work-family conflict on sleep duration by gender from a longitudinal perspective, differentiating between work-to-family (WTFC) and family-to-work conflict (FTWC) as well as time- vs. strain-based conflict.
Background: In previous research, work-family conflict was found to be related to adverse health outcomes. Although sleep is crucial for overall health, relatively few studies have explored the relationship between sleep and work-family conflict, especially with regard to the direction and type of conflict and gender. In exploring these aspects, we apply the Conservation of Resources Theory and Stress Process Theory, in which the distinction between conflict direction and type, as well as gender, is essential.
Method: Using the German Family Panel study “pairfam” and a sample of 3,719 respondents, we apply fixed effects regression models to estimate the effects of time- and strain-based WTFC and FTWC on sleep duration for men and women.
Results: Our results show a negative impact of both WTFC and FTWC on sleep duration, which is consistent with previous findings. Overall, FTWC affects sleep duration more strongly than WTFC. Looking at the type of conflict, the results for WTFC and FTWC differ: for WTFC, the time-based conflict has a stronger effect on sleep duration; for FTWC, the strain-based conflict is more relevant. Gender differences emerge, with men reducing their sleep duration with increasing WTFC and FTWC, while women only with FTWC. For women, only strain-based FTWC decreases sleep duration; for men, mainly time-based WTFC does so.
Conclusion: It seems that the interference of time-based work demands with family life reduces sleep duration primarily among men, whereas when family demands interfere with work it is the psychological strain of the resulting conflict that impacts sleep for women.
`Socio-Demographic Association with Nutritional Status in Children Aged 8-9 Years Old in Surabaya: Focusing on HAZ Status in Path Analysis
Authors: Ardianah Eva , Indriani Diah , Soenarnatalina Melaniani , Widjaja Nur Aisiyah , Santoso Febrina Mustika
Published: January 2025

Background: Child health, growth, and nutrition are influenced by socioeconomic, cultural, demographic, climatic, nutrition, physical, hygiene, sanitation, medical, and environmental factors. LAZ/HAZ was used to assess the presence of 'stunting' in the population, which indicates chronic malnutrition. Objectives: to investigate the socio-demographics, lifestyle (sleep duration, screen time) and HAZ status of children in 2nd and 3rd grade of elementary school, and the correlation of socio-demographics with the anthropometric parameters. Methods: An observational study with a cross-sectional design was conducted during October – December 2022 in Surabaya, involving healthy children aged 9-10 years old who were in 2nd and 3rd grade of elementary school. Results: BMI-for-age z-score was higher in males than females. Overweight/obesity were prevalent in males (15.16% vs. 10.67%), and underweight and severely underweight were prevalent in females (12.27% vs. 14.23%). The prevalence of stunted/severely stunted was 12.39%. HAZ and WAZ were correlated positively with parental height. The number of children in the household had a negative, weak correlation with HAZ. The maternal education showed that the prevalence of maximal elementary school graduation was higher in stunted children than in normal children (29.27% vs. 18.14%, p=0.043). Fathers' salaries below minimum regional wage were more prevalent among stunted and severely stunted (81.71% and 75%, respectively) than normal subjects (60%), p=0.007. Conclusion: Socio-demographic factors affecting the prevalence of stunting in children were the father's salary and maternal education. Meanwhile, factors associated with HAZ were parental height and number of children in the household. The effect of socio-demography on HAZ was mediated by parental education, which stimulates household economics and has a further effect on food intake and child anthropometrics.
Awakening Anti-Bullying Awareness through the "Find Friends" Game in the Boarding School Environment
Authors: Noviyanti Tausyiah Rohmah , Riska Oktaviana  , Aprillia Nurhayati  , Asma Nadia  , Eva Ardiana  , Ira Nurmala
Published: January 2025

Background: Indonesia ranks 4th in violence cases and 2nd in bullying cases worldwide, following Japan. Bullying, increasingly common in school environments, has become a public health issue. Alarmingly, bullying incidents have infiltrated even morally-focused educational settings like Islamic boarding schools. This necessitates effective interventions to raise awareness and curb bullying. The interactive edutainment game "Find Friends," designed for group play, holds promise as a tool to build awareness and encourage positive behavior change in a fun, engaging manner. Objectives: This study aims to analyze the effectiveness of the "Find Friends" game in increasing anti-bullying awareness among students at an Islamic boarding school and promoting positive behavioral changes. Methods: A pre-experimental one-group pretest-posttest design was used in this intervention study, conducted in August 2024 at Pondok Pesantren X, Sukoharjo District. All 31 junior high school students participated as respondents. Data were collected through a checklist assessment and analyzed using the Wilcoxon test. Results: The findings showed no statistically significant difference in students’ knowledge and attitudes toward bullying behavior, although there was a 4.8% increase in the average knowledge scores from pre-test to post-test on anti-bullying awareness. Conclusion: Although "Find Friends" demonstrated potential in boosting anti-bullying awareness, students' knowledge levels on bullying behavior did not significantly change in this study. Factors such as pre-existing knowledge from school may have influenced the results. Future studies with larger samples and extended intervention periods are recommended to explore the deeper impact of the game and to refine its methods for enhanced effectiveness.
Management Visit Evaluation to Improve the Quality of Ponek Services at Bhakti Wira Tamtama Hospital Semarang
Authors: Agus Widodo  , Sri Sundari
Published: January 2025

Background: All hospital staff, both functional and managerial, are responsible for continuous quality improvement. Bhakti Wira Tamtama Hospital in Semarang has committed to sustainable quality improvement. This commitment is embodied in the innovative work program of the Hospital Quality and Patient Safety Committee (KMKP) of Bhakti Wira Tamtama Hospital in the form of Management Grand Rounds. This innovative work program involving management visits by the Quality and Patient Safety Committee at Bhakti Wira Tamtama Hospital has been implemented for about three years but has not been evaluated for its effectiveness. Objective: To evaluate the Management Visit in the Ponek Department of Bhakti Wira Tamtama Hospital Semarang. Methods: The type of research used in this study is a Mixed-method research design known as The Explanatory Sequential Design. Mixed Method research is a method for analyzing, collecting, and blending quantitative and qualitative research methods within a single study to understand the research problem better. Results: The Influence of Internal Factors on Staff Perception Based on the hypothesis testing results, a P-Value of 0.179. The Influence of Staff Perception on Service Quality Improvement Based on the hypothesis testing results, a P-Value of 0.000 was obtained. Conclusion: Internal factor variables have no significant influence on staff perception. There is a significant influence between the staff's perception variable regarding service quality improvement, with a correlation value of P-Value = 0.000. This result is supported by in-depth interviews that indicate positive reception by the medical staff.
Effects of Psychosocial Rehabilitation Interventions for Schizophrenia Patients in Hospitals: Literature Review
Authors: Widoretno Anggun Wahyu , Muji Sulistyowati
Published: January 2025

Background: Schizophrenia is one of the major mental health problems in Indonesia. Pharmacotherapies alone are not sufficient, psychosocial rehabilitation interventions also should be included in the treatment plan. Handling schizophrenia using pharmacotherapy alone is not enough, psychosocial rehabilitation intervention is also needed to complement the treatment. Psychosocial rehabilitation seeks individual independence by improving psychosocial function. Many interventions can be given, but not all of them can be applied in hospitals in Indonesia. Objective: This literature review aims to identify psychosocial rehabilitation interventions in hospitals in Indonesia and how it affect for schizophrenia patients. Method: The research was conducted using Google Scholar. The keywords used was “psychosocial rehabilitation intervention, schizophrenia patient, hospital”. The searched literature is limited from 2020 -2024. Based on the search result, 10 relevant articles were obtained. Result: In all articles, psychosocial rehabilitation interventions implemented in hospitals are aimed at individuals. Interventions for families and communities have not been facilitated. The interventions found included Cognitive Behavior Theraphy (CBT), Vocational Rehabilitation, Occupational and Art Therapy (OAT), and Social Skill Training (SST). They can increase treatment adherence, reduce relapse, improve functioning, and enhance recovery. Conclusion: Psychosocial rehabilitation intervention has positive impacts for schizophrenia patient. But support from family and community will optimize the return of social function for schizophrenia sufferers.
The Emotional Battle of The Sexes Game: Psychological Game Theory Applied to the Choice of Tourism
Authors: Mas Jose M. , Erdmann Anett , Jaszus Kathrin
Published: January 2025

Purpose - Beach or mountain? This study focuses on the complex decision-making process
travelers face when choosing a destination, highlighting the significant but understudied role
of emotions in destination choice, particularly how emotional expectations influence tourism
evaluation. The aim is to derive insights for a strategic choice of image positioning.
Methodology, Design, and Approach - Using psychological game theory, the study examines
the emotional responses of German tourists in their choice of tourism type on the Balearic
Islands, through neuromarketing techniques (EEG, SCR, HVR) and a value assessment
survey. This approach models tourists’ decision-making processes in response to visual
stimuli, incorporating perceived value and an “emotional care” parameter that accounts for
the desire to meet the expectations of travel companions.
Results - The study reveals clear differences between equilibria based on purely self-reported
value judgments and those incorporating neural responses, highlighting the complexity of
emotional influences on travel decisions.
Originality - This research contributes to the field of tourism by detailing the interplay
between emotional expectations, consideration, and trade-offs in travel decisions. It provides
insights for the development of tailored marketing strategies that address emotional needs in
order to increase satisfaction in shared travel decisions.
INITIAL MANAGEMENT OF HYPOVOLEMIC SHOCK IN CHILDREN – A SYSTEMATIC REVIEW OF THE LITERATURE
Authors: Medeiros Paixão Vitória , Lacerda Costa Marinho Samira , Fernandes Mascarenhas Ana Clara , Diniz Oliveira Monalisa Diniz Oliveira , dos Santos Silva Ingrid Evelyn , Ribeiro Pereira de Assis Celiana Ribeiro Pereira de Assis
Published: January 2025

Introduction: Hypovolemic shock in children is a critical condition that occurs when there is a significant loss of intravascular volume, leading to decreased tissue perfusion and compromising organ function. It can be triggered by several factors, such as dehydration, hemorrhages and gastrointestinal conditions, which can lead to a rapid deterioration of the clinical condition. The patient presented with tachycardia, hypotension, weakness, and signs of hypoperfusion, requiring early evaluation and diagnosis. Initial treatment focuses on rapid rehydration and volume replacement, as well as specific measures to address the underlying cause. Thus, the present study aims to perform a systematic review of the literature on the initial management of hypovolemic shock in children. Methodology: This systematic literature review study was developed from the search of indexed articles, cross-sectional studies and retrospective case studies, in which 20 articles were found in the period from 2015 to 2024, consulted in the National Library of Medicine (PubMed MEDLINE) and Scientific Electronic Library Online (SciELO) databases. Of these 10, 3 articles were selected for the systematic review of the literature. Articles were included considering the type of shock, which is hypovolemic shock, the age group of children aged 0 to 10 years, and the publication date from 2015 to 2024. Results and discussion: It was observed that in most cases, there is a good response of the pediatric group to volume replacement with colloid fluids. However, if there is no response to fluids, which is assessed by improving vital signs, level of consciousness, and diuresis, it may be necessary to consider the use of vasoactive drugs. Conclusion: The initial management of hypovolemic shock in children is a critical intervention that can save lives. Early identification, appropriate support, and volume resuscitation are essential steps to restore perfusion and minimize complications. Continuous training of health teams in emergency protocols is critical to improving outcomes in children affected by this condition.
MAIN NEONATAL HARMS ASSOCIATED WITH CESAREAN: A INTEGRATIVE REVIEW
Authors: Pablo Emanoel Damasceno Alves da Silva  , Ian Mendonça Dantas de Matos  , Samyra Maria Fontes de Sousa  , João Gabriel Jacinto  , Fabiana de Andrade Bringel
Published: January 2025

Introduction :The Cesarean Section is a medical procedure widely utilized. Originally, it was conceived as a last-resort intervention to save the life of the mother or fetus in critical situations. Over the years, however, it has become an increasingly common option, often favored by pregnant individuals given the perception of safety at the final stages of pregnancy. Factors such as maternal comorbidities, financial incentives and the lack of birth plans during prenatal care contribute significantly to the increase of CS rates. Nonetheless, this growing preference is not without its adverse impacts. Goals: To analyze the main neonatal harms associated with Cesarean Section.Methodology: This study comprehends an integrative review of the literature, utilizing the PubMed/Medline database and articles repositories (PUC-Goiás and E-Acadêmia). The research was conducted using the boolean operator “AND” and the keywords: “Cesarean Section”, “Infant”, “Newborn” and “Neonatology”. Five articles were selected for full reading, according to inclusion and exclusion criteria  – articles published over the past six years and related to the subject, excluding incomplete or duplicated articles.Results: Studies indicate that Cesarean Section is associated with neonatal harms, such as respiratory problems, increased risk of infections, immunological disorders and possible impacts on neurological development. Vaginal delivery promotes the perinatal stress that stimulates pulmonary maturation through increased production of catecholamines and cortisol, processes absent in CS. Babies born by Cesarean Section are colonized by hospital bacteria, impairing immunological development. The correlation between the type of delivery and neurological disorders is yet inconclusive. Beyond that, CS is related with reduced skin-to-skin contact and reduced initial breastfeeding.Discussion: Despite necessary in several cases, CS presents substantial risks to the newborn. The respiratory complications result from the lack of physiological stress of vaginal delivery, which is essential to extrauterine respiratory adaptation. Bacterial colonization in CS can impair the immune system, increasing vulnerability to infections and allergies. Reduced skin-to-skin contact and lack of early breastfeeding can also impact the bond between mother-baby and neonatal health, increasing the need for neonatal interventions. Conclusion: Based on the information analyzed, it is evident that the Cesarean Section, despite being a common practice, is associated with an increase in risk of neonatal complications. The sanitary interventions must be focused on raising awareness of the risks involved and promoting policies that ensure informed choice and appropriate use of this practice.
KEYWORDS: Cesarean Section; Newborn; Infant; Neonatology;
Air quality in the Metropolitan Zone of the Valley of Puebla: Comparative evaluation of CAMS and persistence forecasts
Authors: Castillo-Miranda Javier Omar , Mendoza-Hernández José Carlos , García-Reynoso José Agustín , Pérez-Osorio Gabriela
Published: January 2025

Background on air quality in the Metropolitan Zone of the Valley of Puebla shows that suspended particles smaller than 10 micrometers (PM10) and smaller than 2.5 micrometers (PM2.5) represent a health risk. Puebla’s automatic air quality monitoring system measures PM10 and PM2.5 at five stations in the municipalities of Puebla and Coronango. These measurements allow for determining the Air and Health Index according to the NOM-172-SEMARNAT-2019 standard for these pollutants. The advancement of global pollutant modeling techniques represents an opportunity for air quality management in areas with scarce terrestrial measurements. However, it is necessary to validate global forecasts with ground measurements from georeferenced monitoring stations to reduce uncertainties and determine reliability. The Copernicus Atmospheric Monitoring Service (CAMS) forecast allows atmospheric pollution exploration processes in the study region. This study presents an analysis of the CAMS forecast against the Persistence forecast. The results show that the persistence forecast performs better than the CAMS forecast in general, both for PM10 and for PM2.5. However, using the CAMS forecast for a preliminary evaluation of the prediction of PM2.5 is feasible due to its acceptable values in the comparison criteria of the dichotomous statistics ACCURACY, probability of detection (POD), false alarm rate (FAR), probability of false detection (POFD), success ratio (SR), threat score (TS), equitable threat score (ETS), Heidke skill score (HSS), and odds ratio skill score (ORSS). This work provides valuable insights to both the population and decision-makers, aiding in the enhancement of air quality management and public health strategies.
The Number of Health-Promoting Substances That All Edible Vascular Plants Contain Compared to the Total Number of Health-Promoting Substances of Five Wild Edible Plants (WEPs)
Authors: Åhlberg Mauri K.
Published: January 2025

Introduction: The research results of wild edible plants (WEPs) are scattered over separate research fields and sources, such as phytochemical studies, nutrition sciences, ethnobotany, and plant sciences. I integrate separate fields for foraging practice. The results are new and practical. The research questions: (1) How did I find 65 health-promoting substances in all green vascular WEPs? (2) According to experimental research, how many of these substances prevent Alzheimer's disease? (3) How many species-specific health-promoting substances do five selected invasive WEPs contain? (4) How many Alzheimer’s disease-preventing, species-specific health-promoting substances do these five selected invasive WEPs have? Methods: Data is sought using research databases. All claims are referenced so accurately that every researcher can check the results. Results: All green vascular WEPs contain at least 65 health-promoting substances, and at least 18 prevent Alzheimer’s disease. Five exemplary WEPs contain a species-specific number (101 - 165) of health-promoting substances, at least 24 -57 preventing Alzheimer’s disease. These five species are alien invasive species. They provide ecosystem services like food. Conclusions: The results offer profound reasons for using foraged WEPs and cultivated green edible vascular plants to promote health and longevity. Using the five alien invasive species researched for culinary purposes is wise.
Origins and Unification of the Four Fundamental Forces of Nature
Authors: Liu Shangqing
Published: January 2025

The four fundamental forces of nature are extremely important because they dominate the formation and evolution of the universe. However, until now, their physical origins and essential qualities have not been explained with wide acceptance. Based on new and solid understandings, this paper provides new explanations for the origins and essences of these four forces, that is, all four fundamental forces originate from the electric force and can therefore be unified as one force. First, the gravitational force is a synthetic electric force produced by a huge number of electric charges via non-uniform charge distribution. Next, based on a novel inference of nuclear structure, which is strongly supported by observed phenomena, the strong and weak forces are also deduced to be electric forces. These introduced new understandings can explain observed confusing phenomena simply and effectively, such as “dark matter,” “dark energy,” “flat galaxies,” “filamentary nebulae,” and “gamma-ray bursts” in nuclear fission or fusion and from black holes. The author presents these new understandings in an effort to find the natural truth earlier.