bluuebunny/crossref_metadata_2025 huggingface dataset:
Type 2 diabetes mellitus: course and outcomes of pregnancy on the example of a clinical case
Authors: Batrak G. A. , Batrak N. V. , Zhaburina M. V.
Published: January 2025

In recent years, the study of the course and outcomes of pregnancy in the presence of type 2 diabetes mellitus (DM) has attracted more attention from researchers. Type 2 diabetes mellitus most often develops in adults, but in recent years it has often occurred in young women planning a pregnancy. Type 2 DM in the mother is associated with pregnancy complications and an increase in adverse outcomes for both the woman and the newborn. Short-term complications include macrosomia, respiratory distress syndrome, neonatal hypoglycemia, congenital fetal malformations, and in the long term, both the mother and the child have a high risk of metabolic diseases. The results of scientific studies confirm that type 2 diabetes, especially in the context of obesity, is closely associated with pregnancy complications: early and late threatened miscarriage, arterial hypertension, moderate and severe preeclampsia, premature detachment of a normally located placenta, placental insufficiency, diabetic fetopathy and intrauterine fetal death, premature birth and low Apgar score of the newborn. Prevention of the development of adverse outcomes for both mother and child in type 2 diabetes is careful pregnancy planning against the background of normoglycemia and achieving target glucose values throughout pregnancy. Self-monitoring of blood glucose is widely used in diabetes of any type to correct treatment, while an important aspect of self-monitoring of glycemia is the correct choice of a glucometer, which reduces the likelihood of errors. One of the accurate and convenient modern glucometers, used including in pregnant women with diabetes of any type, is Contour®Plus ONE. A clinical case of the course and outcomes of pregnancy in a patient with type 2 diabetes is presented.
Enhancing lowland rice physiology with integrated nitrogen nutrient sources in Nigeria’s derived savannah
Authors: Iyanda Olumayowa Joseph , Oyekanmi Akeem Abdulai , Atayese Mufutau Olaoye , Adejuyigbe Christopher , Afolabi Ayomide
Published: January 2025

Nitrogen is an essential nutrient for optimal rice growth and yield. Many Nigerian rice fields encounter difficulties in their production process because of insufficient nitrogen in the soil leading to reduced crop yields. However, the sole reliance on expensive inorganic nitrogen fertilizers is economically challenging for small farmers in Nigeria’s derived savannah. Therefore, integrated approaches to nutrient management have been put into practice to reduce the adverse effects of climate change and improve crop productivity in lowland rice cultivation. We aimed to investigate the impact of integrated nutrient inputs on the performance of NERICA L-34 and ARICA 3 rice varieties during the years 2017, 2018, and 2019.
Various treatments were administered, namely 100 kg of nitrogen/ha (NPK), 75 kg/ha (NPK) + 25 kg/ha (manure), 50 kg/ha (NPK) + 50 kg/ha (manure), 25 kg/ha (NPK) + 75 kg/ha (manure), and 100 kg/ha (manure). A control group was samples without fertilizers. Key physiological parameters were assessed, including partial factor productivity, nitrogen uptake, nitrogen utilization efficiency, nitrogen internal utilization efficiency, physiological efficiency, recovery efficiency, total leaf area index, chlorophyll content, as well as root fresh and dry weights. Our research followed a randomized complete block design with a split-plot arrangement, replicated three times. The data underwent analysis of variance and the Duncan multiple range test (with a significance level set at p ≤ 0.05), and GENSTAT was used to compare the physiological traits of the rice varieties.
Our findings revealed that the combination of 75 kg/ha (NPK, inorganic) and 25 kg/ha (manure, organic) significantly enhanced nutrient recovery and uptake in the NERICA L-34 rice variety, resulting in improved nitrogen absorption. While the ARICA 3 variety consistently exhibited higher chlorophyll content, especially with the application of 100 kg nitrogen/ha (organic), NERICA L-34 displayed superior overall nutrient absorption, recovery, and nitrogen utilization. Therefore, we recommend that rice farmers prioritize cultivating NERICA L-34 for its high productivity and potential for sustainable rice farming.
Our findings can also guide farmers towards feasible integrated soil fertility management practices to enhance nutrient utilization efficiency, reduce environmental impact, and contribute to sustainable rice production in the derived savannah region of Nigeria.
Forsythiaside A Ameliorates Inflammation by Regulating the Autophagy in Methotrexate-induced Intestinal Mucositis
Authors: Lang Wuying , Zhang Jiayi , Xiao Xuejun , Cheng Min , Zheng Xin , Gong Haizhou , Ali Ihsan , Zhao Yongping , Jia Feng , Wang Zhe , Wang Jing , Li Wei , Zhang Haihua
Published: January 2025

Background:

Methotrexate (MTX) effectively eliminates cancerous cells but can also
cause inflammation intestinal, known as mucositis. Forsythiaside A (FTA) from Forsythia suspensa
has shown promise in relieving mucositis by targeting the NLRP3 pathways. Since NLRP3
inflammasome activation is negatively regulated by autophagy, this study explores how FTAmediated
autophagy affects NLRP3 inflammasome in treating MTX-induced intestinal inflammation.

Method:

Intestinal mucositis was induced in rats with MTX. FTA's impact was assessed using
HE staining and ELISA. The mechanism was studied using immunofluorescence, western blot,
and ELISA.

result:

FTA treatment resulted in reduced levels of D-lactic acid and diamine oxidase (DAO) in
MTX-treated rats. Western blot and immunofluorescence analyses revealed up-regulation of Beclin-
1 and LC3II/I, accumulation of LC3, and down-regulation of p62 expression levels in MTXtreated
rats following 40 or 80 mg/kg FTA intervention. However, when the autophagy inhibitor
3-MA was used, the intestinal pathology was exacerbated, the inflammatory scores increased,
and serum levels of TNF-α, IL-1β, and IL-18 were elevated. Western blotting indicated decreased
LC3II/I expression, while NLRP3, cleaved caspase 1, and cleaved IL-1β expressions
were upregulated.

Conclusion:

These findings suggested that FTA alleviated MTX-treated intestinal mucositis by
activating autophagy, which in turn inhibits the NLRP3 inflammasome.
Late Endovascular Treatment for Ischemic Stroke with Moderate to
Large Infarct Volume is Associated with a better Clinical Prognosis
Authors: Jiang Peng , Zhang Sheng , Yu Weitao , Shi Zongjie , Jiang Xinzhao , Wang Xu , Lin Longting , Parsons Mark , Guo Wenting
Published: January 2025

Objective:

The concept of “time is brain” is crucial for the reperfusion therapy of ischemic
stroke. However, the Infarct Growth Rate (IGR) varies among individuals, which is regarded
as a more powerful factor than the time when determining infarct volume and its association
with clinical outcomes. For stroke patients with a similar infarct volume, a longer time from
stroke Onset to Imaging (OTI) correlates with a lower IGR, which may indicate a better prognosis.
This study aimed to compare the prognoses of patients with anterior circulation stroke who received
Endovascular Treatment (EVT), specifically comparing early EVT vs. late EVT.

Methods:

We analyzed 255 patients with acute anterior circulation stroke due to large vessel occlusion
and who have successfully undergone recanalization after EVT. All patients were divided
into the late (OTI≥6 hours) and early (<6 hours) time window groups and compared. The primary
outcome was moderate functional prognosis, defined as a modified Rankin Scale (mRS) ≤3 at 90
days. The secondary outcome was No Significant Infarct Expansion (NSIE), defined as a reduction
of less than 2 points on the Alberta Stroke Program Early CT Score (ASPECTS).

Results:

In the moderate to large infarct subgroup, the late time window EVT was independently
associated with a higher rate of moderate functional outcome (P =0.007) and NSIE (P =0.001);
mediation analysis showed that NSIE partially mediated the effects of the late time window EVT
on moderate functional outcome (coefficient: 0.112, 95% CI: 0.051 to 0.239, P =0.011); however,
these associations were not consistent in the small infarct group.

Conclusion:

For anterior circulation stroke patients who received EVT according to current guidelines,
those with moderate to large infarct volume and having a longer OTI had better clinical outcomes
than those who had a shorter OTI and were more suitable for EVT.
Galegine, a Bioprivileged Alkaloid from Tithonia tubaeformis: Antipyretic Activity Insights
Authors: Nawaz Noor Ul Ain , Saeed Muhammad , Faizi Shaheen , Ali Irfan , Shafiq Muhammad , Shahid Muhammad , Rabbi Fazle , Khan Fahim Ullah , Sharif Rabeea , Ul-Haq Zaheer , Khan Khalid Mohammed , Hemeg Hassan A , Al Abdulmonem Waleed , Aljohani Abdullah S. M , Rauf Abdur
Published: January 2025

Background:

In continuation of our chemical and biological work on Tithonia tubaeformis,
we evaluated the antipyretic activity of its extract which on fractionation gives a pure alkaloid
galegine. Galegine a bioprivileged compound, is a hemiterpene bearing a guanidine group,
which holds significant importance in medicinal chemistry. Biological activities such as antimicrobial,
antidiabetic, anti-inflammatory, cardiovascular, anticancer, and antihypertensive, are often
associated with guanidine-containing molecules.

Objective:

Given the biological importance of guanidine and in search of safe antipyretic agents
from natural resources, an in vivo antipyretic activity of methanolic extract of T. tubaeformis and
galegine was conducted to discover a potential hypothermic drug candidate from the plant.

Methods:

In vivo, the antipyretic activity of galegine (5, 25, and 50 mg/kg doses) and methanolic
extract of T. tubaeformis (50, 100, and 200 mg/kg doses) was investigated by employing yeastinduced
pyrexia in mice model. In silico molecular docking analysis involving target enzymes cyclooxygenase-
1 (COX-1), cyclooxygenase-2 (COX-2), and microsomal prostaglandin E synthase-1
(mPGES-1) was conducted. Additionally, galegine underwent ADME/T profiling using SwissADME
and Protox-II tools to evaluate its bioavailability and safety profiles.

Results:

Both the extract and galegine showed a progressive dose-dependent reduction in body
temperatures of the hyperthermic test animals. Moreover, in silico molecular docking analysis revealed
significant binding affinities ranging from -3.58 to -5.41 kcal/mol. ADME/T analyses of
galegine predicted its high drug-likeness and good safety profile.

Conclusion:

These biological and computational approaches supported T. tubaeformis in addressing
pyrexia, with the isolated compound galegine emerging as a promising antipyretic agent.
High-value Utilization of Liubao Tea Residues: Physicochemical Properties and Immunomodulatory Activity of Alkali-extracted Cell Wall
Polysaccharides
Authors: Li Beibei , Sun Yizheng , Wang Huiqin , Ji Xinying
Published: January 2025

Objective:

Liubao tea residues, often discarded as waste, may contain valuable bioactive
compounds as polysaccharides. To characterize the physicochemical properties of polysaccharides
extracted by 4 mol/L KOH (KTP) and investigate its effects on macrophage activation and immune
response.

Method:

KTP was extracted using an alkaline method. Physicochemical characterization was performed
using monosaccharide analysis, molecular weight assessment, FT-IR spectroscopy, XRD,
and NMR spectroscopy. Immunomodulatory effects were evaluated through macrophage activation
assays, focusing on NO production, cytokine release, and NF-κB pathway modulation.

Results:

Monosaccharide analysis identified KTP as a composite of arabinose, mannose, galactose,
glucose, and xylose with distinct variations in abundance. Molecular weight analysis revealed KTP
as a heterogeneous polysaccharide with fractions KTP-1 and KTP-2 of different molecular sizes.
Structural characterization analysis showed specific functional groups, bond arrangements, and helical
conformations, elucidating KTP’s intricate surface morphologies and semi-crystalline nature.
Additionally, immunomodulatory studies demonstrated KTP’s activation of macrophage pathways
via the NF-κB pathway, increasing nitric oxide (NO) and pro-inflammatory cytokine production
dose-dependently.

Conclusion:

This study reveals KTP's rich structural diversity and potent immunomodulatory activity,
highlighting its potential as a natural immune booster and possible application in developing
functional foods.
Characterization of Lithium-containing Fly Ash Derived from Coal-fired Power Plants in Guizhou Province, China
Authors: Mu Xiwei , Lv Longjiao , Cao Xiru , Liu Jingfeng , Li Fayue , Liu Chunying , Ren Yuting , Ban Cao , Ren Bozhi , Xu Shengjiao , Wu Zhengchuan , Zhu Guocheng
Published: January 2025

Background:

Coal-fired power plants, such as those located in Guizhou, are generating
substantial amounts of fly ash. This fly ash is rich in lithium, a highly valuable metal utilized in numerous
industrial applications. Effective extraction of these metals necessitates a thorough understanding
of their characteristics within the fly ash.

Methods:

Multiple analytical techniques were used to study fly ash's physicochemical properties.
Meanwhile, wet magnetic separation and acid-base methods are employed to separate its mineral
phases.

Results:

The fly ash mainly contains mullite, glass, and iron microspheres, showing spherical particle
morphology. It's rich in O, Si, Al, Fe, C, and oxides like SiO2, Al2O3, Fe2O3. Most particles are
smaller than 20 μm. Lithium in the ash existed as Li-O-M compounds, mainly in the non-magnetic
and glass phases.

Conclusion:

Overall, these findings have deepened our understanding of fly ash and the distribution
of lithium within it, providing a foundation for the recovery of lithium and other valuable elements.
From Paper to Digital: Evaluating Electronic Medical Records and their
Compliance with EMA Guidelines in European Clinical Trials
Authors: Stabile Stefano , Testoni Sara , Franchina Veronica , Betti Marta , Mannozzi Francesca , Ferrari Alessandra , Federici Irene , Doungue Ludovic , Cagnazzo Celeste
Published: January 2025

Background:

Over the past decade, there has been a significant shift from paper-based
to digital medical record management, driven largely by advances in digital technology. This transition
has led to widespread adoption of Electronic Medical Records (EMRs), with the expectation
that paper documentation will soon be fully replaced. In response, the European Medicines Agency's
“Guideline on Computerised Systems in Clinical Trials” outlines essential criteria for validated
EMR systems to ensure data integrity and security, and sets standards for electronic source documents
in clinical trials.

Methods:

From December 2023 to March 2024, the Italian Group of Data Managers and Clinical
Research Coordinators (GIDMcrc) conducted an online survey across clinical research sites in Italy,
France and Belgium to assess the characteristics of medical records and source documents.

Results:

The survey was completed by 37 centres: 70.3% from Italy, 16.2% from France and
13.5% from Belgium. Most sites use a mixed paper/electronic Source Document (SD) system
(72.3%), with fewer centres having fully electronic SD systems (13.5%) or fully paper-based systems
(16.2%). EMR systems are used in 70.3% of sites, but only 23.8% comply with EMA guidelines
for computerised systems. A country-specific analysis was also conducted to further explore
the situations in Italy and France/Belgium.

Conclusion:

Despite the widespread use of electronic medical records (EMRs) in Italy, France
and Belgium, Italy lags behind the other two countries in terms of digitization. Despite the presence
of an EMR, many centres still use a mixed system of paper and electronic source documents.
There is also a lack of awareness regarding EMA and GCP standards, particularly concerning
training and system testing. The higher response rate from Italian centres highlights the need for a
larger sample in France and Belgium, and a follow-up survey would be beneficial for assessing
progress and refining corrective actions.
Sesquiterpene Coumarins as Promising Antiviral Agents: An In-Silico Study
Authors: Dastan Dara , Ebadi Ahmad
Published: January 2025

Background:

Sesquiterpene coumarins are a unique class of natural compounds with a wide range of biological activities. These C15 terpenes are connected by ether or carbon-carbon bonds to coumarin derivatives. Sesquiterpene coumarins that include a 7-hydroxylcoumarin (umbelliferone) moiety have significant antiviral properties. The natural flexibility of these compounds reduces the likelihood of developing resistance, which is often seen in viruses due to high mutation rates.

Objective:

The lessons learned from the coronavirus pandemic experience emphasize the importance of preparedness for future viral outbreaks in the medical community. Conse-quently, fast and reliable assessment methods, such as in silico techniques, are crucial in drug discovery.

Methods:

In this study, we used in silico studies to evaluate the potential antiviral effects of various sesquiterpene coumarins.

Results:

The binding free energy to the spike protein of SARS-CoV-2 suggested that 5′-hydroxyumbelliprenin (2), conferol (9), 8′-acetoxy-5′-hydroxyumbelliprenin (3), and Sanandajine (1) could be promising antiviral candidates.

Conclusion:

These compounds have unique physicochemical characteristics and occupy distinct chemical spaces compared to synthetic libraries; therefore, the criteria for drug-likeness need to be adjusted for this series of compounds.
Association of Angiotensin-converting Enzyme 2 (ACE2) Gene Polymorphisms with the Risk of COVID-19 Severity in the Malaysian Population
Authors: Chong Eric Tzyy Jiann , Bernard Bronsson Khusaidie , Lee Heng Gee , Tan Yee Ann , Chan Lan Lan , Lee Qin Zhi , Saw Yen Tsen , Wong Yiko , Aizudeen Bin Zakaria Ahmad , Lee Ping-Chin
Published: January 2025

Introduction:

The global impact of coronavirus disease 19 (COVID-19), caused by the
SARS-CoV-2, has presented unprecedented challenges worldwide. Previous studies have shown an
association between angiotensin-converting enzyme 2 (ACE2) single nucleotide polymorphisms
(SNPs) and the risk of COVID-19 severity in different populations. However, it remains unclear in
the Malaysian population.

Method:

Therefore, this study aims to investigate the association between four ACE2 SNPs
(rs2074192, rs2285666, rs714205, and rs4240157) and COVID-19 severity in the Malaysian population.
In brief, genomic DNA was extracted from the peripheral blood of 215 recovered COVID-19
patients. The ACE2 SNPs were genotyped using a real-time polymerase chain reaction approach.
Odds ratios and 95% confidence intervals were calculated using the MedCalc software for risk association
analysis. The linkage disequilibrium (LD) and haplotype analyses were assessed using the
SHEsis software.

Result:

This study revealed that the presence of the recessive T allele in the rs2074192 SNP increased
the risk of COVID-19 severity in the Malaysian population. On the other hand, the recessive
T allele in the rs2285666 SNP and the recessive G allele in the rs714205 SNP are reduced risk factors
for COVID-19 severity in the population. LD analysis showed that these four SNPs are independent
of each other. For haplotype analysis, the CCGT and CTGC haplotypes exhibited a decreased
risk, while the TCCC haplotype revealed an elevated risk of severe COVID-19 in the Malaysian
population.

Conclusion:

This study suggests a significant association between the independent ACE2 SNPs
(rs2074192, rs2285666, and rs714205) and haplotypes with COVID-19 severity in the Malaysian
population. This finding can assist in determining an individual’s susceptibility to experiencing severe
COVID-19 and in predicting their response to drugs.
SARS-CoV-2 Infections and Long COVID as Drivers of Accelerated Biological Aging in Endothelial Cells Related to Oxidative Stress
Authors: Tricarico Gerardo , Travagli Valter
Published: January 2025

Recent studies have reported that severe cases of COVID-19 are primarily characterized
by endotheliitis (or endothelialitis), whose severity is related to the pre-existing or current damage to
the complex structure that lines the surface of the vascular endothelium, most notably the glycocalyx.
Such damage results in the loss of many endothelial cell functions. To restore these functions, the
cell must repair the glycocalyx that covers it. However, this is not always possible, especially when
the repair capacity of such an exo-endo-cytoplasmic cell structure is limited due to cellular senescence.
If the gene repair system remains activated, the damaged glycocalyx can be reconstituted via
specific transcriptional pathways in response to oxidative and reductive stresses. Despite the experimental
evidence in favour of this hypothesis, many of the recently published reviewrs on long
COVID do not mention the use of therapeutic treatments via specific 'oxidative eustress'. In fact,
mild and controlled oxidative stress is able to induce an activating response to cellular damage repair
processes. This perspective aims to draw the attention of researchers to these aspects in an attempt to
address this gap in understanding.
Exosomes from Different Sources in Promoting Wound Healing
Authors: Yi Ruiqi , Yang Xiaolu , Tian Ya , Zhang Fen , Anayyat Umer , Zhang Xiaoting , Xiaomei Wang
Published: January 2025

Exosomes are nanoscale extracellular vesicles with various biological activities that can accelerate
wound healing by regulating inflammatory responses, promoting cell proliferation and angiogenesis,
and other mechanisms. Among them, plant and animal exosomes have demonstrated unique
advantages due to their biological characteristics. Plant exosomes have gradually become a research
hotspot due to their wide source, high biosafety, and low production cost, demonstrating significant
pro-healing potential. In addition, animal exosomes, especially human-derived stem cell exosomes,
have shown excellent results in promoting wound repair and have become the focus of clinical research.
This review explores the mechanism of action of these exosomes and their application prospects
in wound healing, providing theoretical support for future research and clinical applications.
Suriyeli göçmen özel gereksinimli öğrencilerin Türkiye’deki eğitim durumları: Özel eğitim öğretmenlerinin görüşleri
Authors: Kocaoğlu Abdulkadir , Güner Nevin
Published: January 2025

2011 yılında Suriye’de başlayan iç savaş nedeniyle üç buçuk milyondan fazla Suriyeli göçmen Türkiye’ye göç etmiş, bu göçmenler için beş ilde yedi Geçici Barınma Merkezi (GBM) kurulmuştur. Bu merkezlerde göçmenlerin beslenme, barınma, güvenlik, sağlık ve eğitim gibi temel ihtiyaçları karşılanmaya çalışılmaktadır. Göçmenlerin yaklaşık yarısı (%48,8) okul çağındaki çocuklardan oluşmakta ve aralarında özel gereksinimli olanlar da bulunmaktadır. Bu çalışmada, Türkiye'nin Suriye sınırına yakın bir ilindeki GBM'de bulunan okullarda Suriyeli göçmen özel gereksinimli öğrencilerle (SGÖGÖ) çalışan sekiz özel eğitim öğretmeninin deneyimleri incelenmektedir. Nitel araştırma yöntemi desenlerinden fenomenolojiyle tasarlanan çalışmada, veriler yarı yapılandırılmış görüşmelerle toplanmış ve betimleyici fenomenolojik analizle incelenerek yedi tema ve 19 alt tema elde edilmiştir. Sonuçlar incelendiğinde özel eğitim öğretmenlerinin çalıştıkları ortamın fiziksel özelliklerini yeterli buldukları ancak dil ve kültür farklılıkları nedeniyle SGÖGÖ’lerle çalışırken zorlandıklarını ve nitelikli bir eğitim veremediklerini ifade ettikleri görülmüştür. Ayrıca öğretmenler, Suriyeli göçmen ebeveynlerin çocuklarının özel gereksinim durumuna kaderci bir yaklaşım sergilemelerinin ve çocuklarının eğitimine yeterince önem vermemelerinin, SGÖGÖ’lerin eğitim yaşamlarını olumsuz etkilediğini belirtmişlerdir. Bu nedenle öğretmenler, Suriyeli göçmen ebeveynlerin özel eğitim hakkında bilinçlendirilmesi için çalışmalar yapılmasını ve gereksinim duydukları desteklerin sağlanmasını önermişlerdir.
The relationship between acculturation types enculturation stress and collective self-perceptions students of Syrian refugees in Turkey
Authors: Keleş Fadim Büşra , Uçar Mehmet Ertuğrul
Published: January 2025

Migration occurs when individuals move from one society to another. During this process, they undergo various stressors, including general stress and cultural stress, as they adapt to a new culture. The adaptation to this new culture, including both the individual's original cultural background and the new cultural elements they adopt, is termed acculturation. Acculturation involves several processes: integration, assimilation, separation, and marginalization. This research aims to examine whether the acculturation preferences of Syrian refugee students under temporary protection can be predicted by perceived stress, acculturation stress, and collective self-esteem. To achieve this, a stepwise regression model was developed and tested. Data was collected using a Personal Information Form, Acculturation Stress Scale, Perceived Stress Scale, and Collective Self-Esteem Scale. The study group comprised 282 individuals, including 127 girls and 155 boys, who migrated from Syria to Turkey at different times and are currently pursuing formal education. The results of the stepwise regression analysis indicated that collective self-esteem, acculturation stress, and perceived stress were predictors of separation and assimilation but did not predict integration and marginalization.
Ergenlerin siber zorbalık düzeylerinin incelenmesi
Authors: Keleş Anıl , Tagay Özlem
Published: January 2025

Bu araştırmanın amacı ergenlerin siber zorbalık düzeylerinin çeşitli değişkenler açısından incelenmesidir. Bu değişkenler ergenlerin, cinsiyet, algılanan ebeveyn tutumu, günlük internet kullanım süresi, ebeveynin internet kullanım durumu ile ergenlerin internet kullanımının kontrolü olarak belirlenmiştir. Betimsel tarama modeli kullanılan bu araştırmanın çalışma grubu Isparta ilinde eğitimlerine devam eden 430 lise öğrencisinden oluşmaktadır. Veriler, Özdemir ve Akar (2011) tarafından Türk kültürüne uyarlaması yapılan “Siber Zorbalık ve İnternet Saldırganlığını Tarama Ölçeği” ve araştırmacılar tarafından geliştirilen kişisel bilgi formu kullanılarak toplanmıştır. Verilerin analizinde bağımsız örneklem t testi ve tek yönlü varyans analizi (Anova) kullanılmıştır. Bulgulara göre, ergenlerin siber zorba olma ve siber zorba kurbanı olma düzeyleri cinsiyete, algılanan ebeveyn tutumuna, günlük internet kullanım süresine, ebeveyninin internet kullanım durumuna ve ergenin internet kullanımının kontrolüne göre anlamlı farklılık göstermektedir. Bu farklılık, erkekler, ebeveynlerinin tutumlarını tutarsız olarak algılayanlar, günlük 4 saat ve üstünde internet kullananlar, ebeveyni aşırı teknoloji kullananlar ile internet kullanımı kontrol edilmeyenler lehine gerçekleşmiştir.
Appraisal Team: Responsibility and Principle of Fairness in Determining the Value of the Auction Object Limit
Authors: Muslim Shohib , Noerdajasakti Setiawan , Setyowati Dewi , Siboy Ahmad
Published: January 2025

Appraisal service companies are entities tasked with determining the true value of wealth or property for various trade transaction purposes, but they currently face a range of economic and legal challenges. This study analyses the appraisal team's principles of justice and legal responsibility in setting the minimum bid value for auctioned collateral. Employing a normative legal research method, this research draws on statutory, conceptual and case approaches supported by primary legal material. The findings show that the appraisal team is legally responsible for the values they determine for collateral auctions, with the liability encompassing three main areas, including civil liability. If the team is proven to have violated the provisions of the auction as mentioned in PMK Number 228 / PMK.01 / 2019 concerning Public Appraisers, they may face administrative sanctions, such as written warnings, restrictions on certain appraisal services, suspension of permits, or permit revocation. Furthermore, the Government has provided legal protection to auction buyers with good faith who participate in auctions in compliance with applicable regulations. Fairness must be achieved and upheld through just procedures to ensure fair results, giving all parties equal standing and rights in the auction process.
Pemodelan Debit DAM Sengkaling Berdasarkan Data Curah Hujan Menggunakan Model Jaringan Saraf Tiruan (JST)
Authors: Satria Radifa Satria Pratama , Runi Asmaranto  , Very Dermawan
Published: January 2025

Ketersediaan data debit yang tidak lengkap dan akurat pada suatu Daerah Aliran Sungai (DAS) dapat menyebabkan berbagai permasalahan dalam pemanfaatan sumber daya air. Pada umumnya, data debit diperoleh dari pengukuran tinggi muka air di suatu pos duga air. Pengukuran tinggi muka air dapat dilakukan dengan cara manual meggunakan papan duga air atau cara otomatis menggunakan alat Automatic Water Level Recorder (AWLR). Studi ini berfokus pada Pos Duga Air (PDA) Dam Sengkaling yang berada di DAS Brantas Hulu yang mana masih menggunakan papan duga air dalam pencatatan tinggi muka airnya sehingga hasil pencatatan tersebut bisa saja tidak akurrat bahkan tidak terrcatat karena dalam pencatatannya masih dilakukan secara manual (human error). Penelitian ini bertujuan untuk membuat semacam model hujan menjadi debit, dengan harapan dapat menjadi solusi atas ketersediaan data debit pada lokasi studi. Metode yang digunakan dengan memanfaatkan teknologi komputer menggunakan model Jaringan Saraf Tiruan (JST) dengan input yang digunakan yaitu data curah hujan. Hasil penelitian didapatkan nilai kalibrasi terbaik terdapat pada data 7 tahun dengan 3000 epoch diperoleh nilai r = 0,994 dan NSE = 0,987. Sementara untuk nilai validasi terbaik terdapat pada data 3 tahun dengan 3000 epoch dan diperoleh nilai r = 0,980 dan NSE = 0,948.
Studi Manajemen Konstruksi Pembangunan Tanggul di Sungai Cimanuk Desa Karanganyar Kabupaten Majalengka Dengan Metode Fasttrack Menggunakan Aplikasi Microsoft Project Manager 2016
Authors: Gaol Nobert Fransisco Evert , Pitojo Tri Juwojo  , Suwanto Marsudi
Published: January 2025

Pemerintah Kabupaten Majalengka melalui Kementerian Pekerjaan Umum dan Perumahan Rakyat melaksanakan proyek Pembangunan Tanggul Sungai Cimanuk guna mengatasi permasalahan banjir yang terjadi di Desa Karanganyar. Dalam proses pelaksanaannya, proyek Pembangunan Tanggul memiliki tahapan pekerjaan yang kompleks serta durasi yang berbeda pada setiap item pekerjaannya. Studi ini bertujuan untuk menghasilkan alternatif penjadwalan yang optimal serta pengelolaan proyek secara menyeluruh dengan manajemen sumber daya dan durasi kerja. Pada studi ini, alternatif penjadwalan akan dilakukan dengan menggunakan optimasi percepatan proyek metode fasttrack. Dari hasil optimasi tersebut, didapatkan efisiensi biaya 2,12% dari biaya kontrak. Sedangkan dari segi waktu penyelesaian proyek pada metode fasttrack diperoleh efektivitas durasi sebesar 5,8%.
Aplikasi EPA SWMM 5.1. pada Perencanaan Sistem Drainase Kawasan Perumahan El Banna City Kecamatan Karangploso Kabupaten Malang
Authors: Luiz Agusta Musa Pradana  , Ussy Andawayanti  , Runi Asmaranto
Published: January 2025

Peningkatan jumlah penduduk di Kabupaten Malang menyebabkan peningkatan kebutuhan perumahan. El Banna City adalah contoh perumahan yang mengubah lahan hijau menjadi pemukiman, mengurangi area penyerapan air dan meningkatkan risiko banjir. Kabupaten Malang telah menghadapi masalah banjir akibat pengelolaan drainase yang kurang efektif. Oleh karena itu, diperlukan penelitian tentang perancangan drainase berkelanjutan di area ini. Penelitian ini melibatkan perhitungan analisa hidrologi dan hidrolika serta penggunaan software EPA SWMM 5.1, menghasilkan 102 saluran persegi. Debit air dari perhitungan adalah 1,307 m³/det dan dari simulasi 1,352 m³/det, dengan selisih 0,045 m³/det. Total jumlah sumur injeksi yang diperlukan adalah 96 buah. Dengan perencanaan drainase yang tepat, risiko banjir di Kabupaten Malang diharapkan dapat berkurang, meningkatkan kualitas hidup dan mendukung pembangunan perumahan berkelanjutan.
Analisis Kualitas Air Menggunakan Metode Indeks Pencemaran, CCME-WQI, dan Program QUAL2Kw Di Sungai Manten, Kabupaten Malang, Jawa Timur
Authors: Cahya Putra Halim , Emma Yuliani  , Tri Budi Prayogo
Published: January 2025

Meningkatnya kebutuhan akan air bersih, sanitasi, dan sumber daya lainnya telah mengakibatkan peningkatan volume limbah domestik dan industri yang masuk ke dalam sistem sungai. Analisis ada untuk mengetahui status mutu air Sungai Manten. Analisis yang dilakukan menggunakan metode Indeks Pencemaran (IP), CCME-WQI dan QUAL2Kw. Parameter yang digunakan dalam penelitian ini antara lain BOD, COD, DO, suhu, pH, TSS, Nitrat (NO3-), Nitrit (NO2-), Phospat (PO43-), Ammonia dan TDS. Setelah memperoleh nilai status mutu air Sungai Manten, kemudian akan dilakukan simulasi dengan menggunakan data primer tersebut menggunakan QUAL2Kw. Hasil analisis dengan menggunakan metode Indeks Pencemaran mendapatkan hasil tercemar ringan pada titik hulu dan hilir yang diteliti. Berbeda dengan hasil metode CCME-WQI pada bagian hulu dan hilir yang diteliti mendapatkan nilai cukup dan sedang. Dari metode QUAL2Kw dapat dilihat hasil dari beban pencemar yang masuk ke Sungai Manten dan diketahui bahwa parameter BOD yang melewati batas kelas II.
Studi Pemanfaatan Sumber Siuk Untuk Pemenuhan Kebutuhan Air Baku Perdesaan di Kecamatan Jabung Kabupaten Malang
Authors: Rahmad Aziz Saputra  , Sumiadi  , M. Amar Sajali
Published: January 2025

Salah satu kecamatan yang terletak di Kabupaten Malang adalah Kecamatan Jabung. Dimana di kecamatan tersebut ada 4 desa yang masih kekurangan untuk mencukupi kebutuhan air baku sehari-hari yaitu Desa Pandansari Lor, Desa Gading Kembar, Desa Argosari dan Desa Kemiri. Lokasi yang sebagian berada di wilayah cenderung berbukit-bukit mengakibatkan masyarakat hanya mengandalkan sumber air terdekat dengan jaringan yang sederhana dan bantuan air dari pemerintah. Menyikapi hal tersebut maka penelitian ini memiliki tujuan merencanakan sistem jaringan pipa dalam pemenuhan kebutuhan akan air baku bagi masyarakat. Perencanaan jaringan pipa air baku pada studi ini akan menggunakan aplikasi WaterGems CONNECT Edition 4. Selain itu, dilakukan perhitungan proyeksi jumlah penduduk hingga tahun 2042. Hasil simulasi dengan program WaterGEMS CONNECT Edition 4 pada kondisi tekanan pipa berkisar antara 0,82 – 14,49 atm, kecepatan aliran pipa berada dalam rentang 0,103 – 1,094 meter/detik dan headloss gradient berkisar dengan rentang 0,203 – 10,2 m/km. Serta hasil dari simulasi klorinasi pada jaringan pipa berkisar antara 0,20579 – 0,44087 mg/L. Pekerjaan pembangunan sistem jaringan air baku membutuhkan Rancangan Anggaran Biaya (RAB) sebesar Rp 12.059.929.000,00.
Studi Optimasi Pemanfaatan Air Di Daerah Irigasi Mambal Kabupaten Badung Menggunakan Program Linier
Authors: I Kadek Guntur Karra Kaniskha  , Lily Montarcih Limantara  , Tri Budi Prayogo
Published: January 2025

Daerah Irigasi Mambal di Kabupaten Badung, Bali, memerlukan optimasi dalam penggunaan lahan irigasi dan pola tata tanam untuk meningkatkan hasil pertanian. Hal ini disebabkan karena masih kruang optimalnya penggunaan air pada Daerah irigasi Mambal sehingga membuat beberapa periode pertanian mengalami defisit karena kurang sesuainya luas lahan dan pola tata tanam yang digunakan. Oleh karena itu, studi ini bertujuan untuk menentukan luas lahan irigasi dan pola tata tanam optimal menggunakan metode program linier. Dengan data debit harian selama 10 tahun dari Sungai Ayung, penelitian ini mengevaluasi neraca air sebelum dan sesudah optimasi. Hasil penelitian menunjukkan bahwa optimasi menggunakan program linier dapat meningkatkan penggunaan lahan dari 3.032 Ha menjadi optimal sesuai debit air yang tersedia. Pola tata tanam alternatif memberikan intensitas tanam yang meningkat sebesar 30% dibandingkan kondisi eksisting. Keuntungan yang diperoleh dari pola tata tanam alternatif juga lebih tinggi. Kesimpulan dari studi ini adalah optimasi pola tata tanam dengan metode program linier dapat meningkatkan efisiensi penggunaan lahan dan air, serta menghasilkan keuntungan maksimum bagi petani. Manfaat dari studi ini adalah memberikan rekomendasi praktis bagi pengelola irigasi untuk meningkatkan produktivitas pertanian melalui penggunaan sumber daya air yang lebih efisien.
Studi Erosi Dan Limpasan dengan Arah Angin Dari Sisi Kanan dan Sisi Kiri Menggunakan Rainfall Simulator
Authors: Amalia Fauziah Dwi , Ery Suhartanto  , Jadfan Sidqi Fidari
Published: January 2025

Permukaan bumi akan selalu mengalami fenomena erosi, di satu tempat akan terjadi erosi sementara di tempat lain akan terjadi sedimentasi, sehingga bentuknya akan selalu berubah seiring waktu. Penelitian ini melibatkan simulasi hujan buatan disertai pengaruh arah angin berupa blower NRT-PRO pada sisi kiri dan sisi kanan menggunakan alat rainfall simulator dengan sampel tanah berupa pasir kuarsa. Penggunaan alat rainfall simulator dalam analisis ini memungkinkan simulasi hujan pada skala intensitas 1 liter/menit, 1,5 liter/menit, dan 2 liter/menit. Penelitian menggunakan alat rainfall simulator untuk menguji seberapa besar pengaruh erosivitas hujan yang disertai arah dan kecepatan angin terhadap besaran erosi yang dihasilkan oleh pasir kuarsa. Pada penelitian ini dilakukan analisis perbandingan hasil laju erosi metode USLE (Universal Soil Loss Equation), laju erosi rainfall simulator, dan laju erosi hasil luasan grid rainfall simulator. Hasil dari masing masing pendekatan tersebut memperoleh estimasi besaran laju erosi. Dari analisis dan perhitungan menunjukkan nilai laju erosi menggunakan metode USLE, laju erosi rainfall simulator, dan laju erosi grid rainfall simulator memeroleh hasil yang selaras pada masing masing metode.
Evaluasi Indeks Kinerja Sistem Irigasi di Daerah Irigasi Palasari Kabupaten Jembrana Menggunakan Aplikasi e-PAKSI
Authors: Novia Lelyana  , I Gusti Ngurah Kerta Arsana  , I Putu Gustave Suryantara Pariartha
Published: January 2025

Daerah Irigasi Palasari merupakan salah satu daerah irigasi di Kabupaten Jembrana, Provinsi Bali, dengan luas fungsional sebesar 564 Ha. Sesuai dengan amanat Peraturan Menteri Pekerjaan Umum dan Perumahan Rakyat Republik Indonesia Nomor 12/PRT/M/2015 tentang Eksploitasi dan Pemeliharaan Jaringan Irigasi bahwa perlu dilakukan pengelolaan aset irigasi dan evaluasi kinerja sistem irigasi. Studi ini bertujuan untuk mengetahui indeks kinerja sistem irigasi di Daerah Irigasi yang nantinya dapat dijadikan acuan dalam pengambilan keputusan dalam pengelolaan irigasi di masa mendatang.  Metode yang digunakan untuk memperoleh indeks tersebut adalah dengan melakukan survei Pengelolaan Aset Irigasi (PAI) dan Indeks Kinerja Sistem Irigasi (IKSI) melalui penelusuran jaringan irigasi menggunakan aplikasi Android e-PAKSI yang berbasis web.
Berdasaran hasil survei PAI dan IKSI Daerah Irigasi Palasari menggunakan aplikasi e-PAKSI, diperoleh nilai indeks kondisi operasi dan pemeliharaan jaringan irigasi dan nonjaringan irigasi berdasarkan penilaian enam komponen yang ada di Daerah Irigasi Palasari yaitu prasarana fisik sebesar 24,65%, produktivitas tanam sebesar 12,13%, sarana penunjang sebesar 4,75%, organisasi personalia sebesar 6,50%, dokumentasi sebesar 1,90%, dan P3A sebesar 7,00%. Sehingga, nilai IKSI total untuk Daerah Irigasi Palasari adalah sebesar 56,92%, dengan nilai IKSI dalam interval 55% - 69% menunjukkan bahwa Daerah Irigasi Palasari memiliki kinerja kurang dan perlu perhatian.
Analisa Stabilitas Tubuh Bendungan Muara Juloi Kabupaten Murung Raya Provinsi Kalimantan Tengah
Authors: Luthfi Rico Hardiansyah  , Suwanto Marsudi  , Andre Primantyo Hermawan
Published: January 2025

Bendungan beton padat gilas gravitasi adalah bendungan yang terisi penuh dengan beton yang dipadatkan dengan roller. Tubuh bendungan adalah bagian utama bendungan yang memiliki fungsi untuk menahan air. Analisa stabilitas pada tubuh bendungan diperlukan dalam rencana desain sebuah bendungan, hal ini perlu dilakukan untuk mengetahui tingkat keamanan tubuh bendungan yang ditinjau dari stabilitas terhadap guling dan geser, karena jika stabilitas memenuhi persyaratan teknis, maka bendungan tersebut akan mengalami kegagalan atau keruntuhan. Perhitungan stabilitas dilakukan secara manual dan juga menggunakan software CADAM2D. Dengan perhitungan manual yang mencakup tujuh kondisi pembebanan serta penggunaan software CADAM2D yang juga mencakup tujuh kondisi pembebanan. Nilai perhitungan stabilitas paling tinggi atau dapat dikatakan paling aman terjadi saat kondisi I (kondisi luar biasa – selesai konstruksi) dengan nilai perhitungan 1806.96 pada perhitungan secara manual dan nilai perhitungan >100 pada perhitungan menggunakan aplikasi CADAM2D. Dengan masing-masing letak resultan 56.65% pada perhitungan secara manual dan 44.56 pada perhitungan menggunakan aplikasi CADAM2D.
Evaluasi Kualitas Air berdasarkan Variasi Tata Guna Lahan Sungai Coban Hulu Kabupaten Pasuruan
Authors: Irawan Sharon Kezya Java , Haribowo Riyanto
Published: January 2025

Sungai Coban Hulu merupakan “agricultural river”, mencakup sekitar 61,44% dari total catchment area. Aktivitas pertanian ini disertai dengan penggunaan pupuk, pestisida, dan bahan kimia lainnya, yang berpotensi meningkatkan pencemaran air akibat limpasan permukaan. Penelitian ini bertujuan untuk mengevaluasi kualitas air Sungai Coban Hulu berdasarkan indeks pencemaran (IP) dan Water Quality Index (WQI), serta menganalisis dampak tata guna lahan terhadap kualitas air. Data kualitas air dikumpulkan menggunakan metode grab samples pada bulan Juli 2024 di 11 titik pengambilan yang mencakup wilayah pertanian, pemukiman, dan kawasan industri. Beberapa parameter yang diambil adalah ORP, konduktivitas, pH, salinitas, TDS, suhu, DO, dan kekeruhan. Hasil evaluasi menunjukkan bahwa segmen GB 3.1 memiliki kualitas air terburuk, dengan status “Tercemar Sedang,” sedangkan segmen lainnya tergolong “Tercemar Ringan” dengan rerata nilai IP sebesar 3,04 dan WQI 1,38. Studi ini dapat digunakan untuk peningkatan pengelolaan limbah dan penerapan praktik tata guna lahan berkelanjutan untuk menjaga kualitas air di Sungai Coban Hulu.
The Effects of Family-of-Origin Health on Beliefs About Childbearing Among Unmarried Individuals: The Mediating Effect of Depression
Authors: Lee Eun-Joo
Published: January 2025

Purpose: Family-of-origin health and depression are crucial factors influencing beliefs about childbearing among unmarried individuals. This study explored the mediating role of depression in the relationship between family-oforigin health and beliefs about childbearing among unmarried individuals.Methods: This study included 219 unmarried individuals aged 20 to 40, selected using convenience sampling from a university and church in Changwon city, Korea. Data were collected between June 1 and July 31, 2023, using structured questionnaires assessing family-of-origin health, depression, and beliefs about childbearing. The data were analyzed using descriptive statistics, t-tests, 1-way analysis of variance, Pearson correlation coefficients, and the PROCESS macro model 4.Results: The average age of the study participants was 25.60±4.20 years. The sample comprised 135 females (61.6%) and 84 males (38.4%). Beliefs about childbearing were significantly positively correlated with family-oforigin health (r=0.21, p=0.002) and significantly negatively correlated with depression (r=-0.30, p<0.001). Familyof- origin health was also significantly negatively correlated with depression (r=-0.38, p<0.001). Depression acted as a mediator in the relationship between family-of-origin health and beliefs about childbearing among unmarried individuals, with an indirect effect of 0.04, and a 95% confidence interval of 0.01 to 0.08.Conclusion: This study identified the family-of-origin health as a significant pathway influencing unmarried individuals' mental health and beliefs about childbearing. These findings have implications for interventions to address the declining birth rate.
Evaluation of the Perceptions of Fitness Sports Center Members Towards Service Quality
Authors: Göktepe Mehmet , Soyer Fikret , Çataldirek Serkan , Miyaç Meral
Published: January 2025

This research aimed to evaluate the perceptions of members of fitness sports centers regarding service quality. A relational screening model was used in the research. The universe of the study consists of individuals who are members of sports centers affiliated with Bornova Municipality Sports Affairs Directorate of Izmir Province and who exercise regularly. The sample consists of 395 individuals who are members of these centers and voluntarily participated in the study. "Personal Information Form" and Perceived Service Quality in Sports and Fitness Centers scale developed by Uçan (2007) were used as data collection tools. In addition to descriptive statistics, independent groups t-test and One-way ANOVA methods were used in the analysis of the data. When the research findings were examined, it was observed that there were statistically significant differences in perceived service quality scores according to factors such as gender, educational status, occupational status, purpose of going to the sports center, exercise duration, and preferred sports center (p. 05). As a result, it was determined that service quality factors vary depending on different demographic and personal characteristics.
Bibliometric Insight into Artificial Intelligence Application in Investment
Authors: M.K. Sarjas  , G. Velmurugan
Published: January 2025

This study explores the key trends and ideas around using artificial intelligence in investment. The authors employ the bibliometric approach, using VOS viewer software to analyze 582 academic articles from the SCOPUS database between 2004 and 2023. The findings show that interest in artificial intelligence within investment has grown since 2017, reflecting a delay in its adoption by the investment industry. China, the United States, India, and the United Kingdom were identified as the leading countries researching this topic. The National Research University Higher School of Economics, Russia, and Spiru Haret University, Romania emerged as the most active institution in this area. It highlights the growing adoption of AI across various financial institutions, including banks, hedge funds, and fintech firms, due to its ability to analyze extensive datasets, enhance decision-making, and optimize portfolios. Key AI-driven, cost-effective investment advice. These technologies outperform traditional advisors' inefficiency and objectivity but face challenges in gaining trust among seasonal investors. However, the study has limitations, as it only used articles from the SCOPUS database and focused solely on English–language publications. The future directions emphasize the integration of AI with sustainability and natural language processing, reflecting its potential to address broader societal challenges. The study underlines that extensive regulatory frameworks, improved collaboration, and user-centric AI solutions are required to optimize its influence on investment practices.
Pengembangan E-Book Materi Elektrokimia Berbasis Multipel Representasi Menggunakan 3D Pageflip
Authors: Syahri Wilda , Yusnaidar Yusnaidar
Published: January 2025

Mata kuliah Kimia Fisika II di Prodi Pendidikan Kimia mencakup materi Elektrokimia yang bersifat abstrak, sehingga sulit dipahami mahasiswa hanya dengan penjelasan teori. Untuk itu, dikembangkan e-Book Materi Elektrokimia Berbasis Multipel Representasi menggunakan aplikasi 3D Pageflip dengan pendekatan model pengembangan ADDIE (Analysis, Design, Development, Implementation, Evaluation). Instrumen yang digunakan meliputi angket dan lembar observasi untuk mengevaluasi efektivitas dan penerimaan e-Book oleh mahasiswa. E-book ini dirancang untuk membantu mahasiswa mempelajari dan memahami materi Elektrokimia secara mandiri melalui representasi makroskopik, mikroskopik, dan simbolik. E-book ini diharapkan dapat meningkatkan daya tarik, motivasi, dan prestasi belajar mahasiswa serta menjembatani keterbatasan pemahaman di kelas. Hasil penelitian ini adalah e-Book yang sesuai dengan kurikulum dan kaidah pendidikan yang berlaku