bluuebunny/crossref_metadata_2025 huggingface dataset:
Factores de riesgo psicosocial y salud mental en trabajadores de una empresa textil
Authors: Vargas Jaimes Claudia , Bernaldez Jaimes German Benito , Gil Gomez Ulises
Published: June 2021

Objetivo: A partir de los requerimientos de la Norma Oficial Mexicana NOM-035-STPS-2018 “Factores de riesgo psicosocial en el trabajo, Identificación, Análisis y Prevención”, y de los instrumentos destinados a tal fin, se identificaron y analizaron factores de riesgo psicosocial, la exposición a eventos traumáticos y la salud mental, en empleados de una empresa textil.
Materiales y Métodos: Estudio no experimental transversal descriptivo correlacional, en una muestra de 652 participantes, a través de los cuestionarios: General de Salud, Acontecimientos Traumáticos y Factores de Riesgo Psicosocial. Se realizó estadística descriptiva, correlaciones de Pearson y Anova, todo con un intervalo de confianza de 95%.
Resultados: Dentro de los factores de riesgo: Ambiente de trabajo, Organización del tiempo de trabajo, Liderazgo y Relaciones en el trabajo y Entorno organizacional se encuentran en un nivel bajo, excepto en el rubro de Factores propios de la actividad con un nivel medio. Los trabajadores expuestos a acontecimientos traumáticos severos se manifestaron en un 21%, los trabajadores que requieren atención psicoterapéutica corresponden a un 13%; y 2% presentan riesgo suicida. Las correlaciones realizadas demuestran que al presentarse un acontecimiento traumático, los factores de riesgo psicosociales, del entorno laboral y la salud mental se interrelacionan y por lo tanto afecta la salud mental, física, el ambiente laboral y las actividades de los trabajadores.
Conclusiones: La exposición a acontecimientos traumáticos severos, la salud mental y los factores de riesgo psicosocial están estadística y significativamente relacionados, teniendo incidencia unos sobre los otros, por lo que en general se requieren acciones preventivas y correctivas de intervención, así como capacitación a las actividades a desempeñar.
Contrapublicidad del cigarrillo y actitudes de los adolescentes hacia su consumo
Authors: Guzmán-Facundo Francisco Rafael , Del Ángel-García Julia Elena , Candia-Arredondo Josefina Sarai , Mendez-Ruiz Martha Dalila , Villegas-Pantoja Miguel Angel
Published: June 2021

Objetivo: Comparar las actitudes hacia el consumo de tabaco en adolescentes de secundaria después de la exposición a tres pósteres de contrapublicidad. Materiales y métodos: Diseño preexperimental por comparación de grupos no equivalentes; muestra de 50 adolescentes seleccionados mediante muestreo no probabilístico y asignados a un grupo expuesto a contrapublicidad (n = 25) y un grupo de comparación (n = 25) que permaneció en lista de espera. La estrategia de contrapublicidad consistió en tres pósteres administrados por internet. Los pósteres incluyeron imágenes y mensajes sobre consecuencias del consumo de tabaco. La recolección de datos se efectuó en línea mediante Google Forms. Se utilizó una cédula sociodemográfica y una escala de actitudes hacia el tabaco. Los datos obtenidos fueron procesados a través del paquete estadístico SPSS versión 24.0 mediante análisis inferencial no paramétrico (prueba U de Mann-Whitney). Resultados: Se encontraron diferencias estadísticamente significativas entre ambos grupos (U = 145.0, p < .001) donde los estudiantes expuestos a la contrapublicidad mostraron menor mediana de actitudes favorables hacia el tabaco (Med = 17.0, DE = 5.11) en comparación con los participantes no expuestos (Med = 25.0, DE = 7.91). Conclusiones: Los resultados sugieren que los adolescentes que recibieron la contrapublicidad mostraron menos actitudes favorables hacia los cigarrillos. En particular, la dimensión de índice de desagrado hacia el consumo de tabaco fue la que mostró diferencias significativas entre el grupo expuesto y el de comparación. La información emitida a través de los pósteres sobre las consecuencias del consumo de tabaco podría beneficiar en la modificación de las actitudes hacia el consumo de tabaco en adolescentes mexicanos. No obstante, se manifiesta la necesidad de replicar los resultados con diseños experimentales para calcular con mayor fiabilidad su efectividad.
Frequency of non-alcoholic fatty liver disease in a series of forensic cases in Mexico
Authors: Calderón-Garcidueñas Ana Laura
Published: June 2021

The Mexican population is overweight (34%) and obese (21%). Obesity is a risk factor for non-alcoholic fatty liver disease (NAFLD). Most studies of the frequency and prevalence of NAFLD have been performed using ultrasonography. In Mexico, ultrasound-based studies have shown a prevalence of NAFLD of 15.7 to 17 %. Objective. The objective was to determine the frequency of NAFLD in apparently asymptomatic individuals who died instantly in a traffic accident and with not known background of liver disease. Material and Methods. Autopsies were performed at the Coroner’s Office in the Municipality of Boca del Río, Mexico, during the period from January to December 2016. The variables studied included age, sex, weight, height, abdominal perimeter, fat panicle-thickness, main cause of death, and liver biopsy (NASH CRN classification). Results. Of the 32 cases studied, 78.1 % were males. Average age was 48 years (range 20-80 years). The body mass index range (BMI) was 17-33. A 34% of cases had NAFLD. 27.3 % of the cases with NAFLD had a normal BMI. Conclusions. This postmortem study showed a higher frequency of asymptomatic hepatic steatosis than previously reported in the Mexican population. The establishment of timely national measures to detect and prevent complications of NFALD is necessary.
Cuidado de enfermería perdido y factores contribuyentes en un hospital de Tabasco, México
Authors: López Cocotle José Juan , Silva Ramos María Fernanda , Moreno Monsiváis María Guadalupe , González Angulo Pedro , Interial Guzmán Ma Guadalupe
Published: June 2021

Objective: to determine the relationship between the omission of nursing care and the contributing factors of a hospital in Tabasco, Mexico. Materials and methods: quantitative, descriptive and correlational study in 50 nurses of different shifts of a public hospital, we used the MISSCARE survey that allows identifying the lost nursing care and the related factors, for the analysis we used descriptive statistics and Spearman's correlation coefficient, we considered what is stipulated in the Regulation of the General Law of Health in Matters of Health Research. Results: the dimension where the greatest omission of care occurred was that of basic care interventions (M= 22.6, SD= 14.2). The factors that contributed most to the omission of nursing care were human resources (M= 75.8, SD= 18.3). Material resources showed weak negative and significant association with continuous assessment interventions (rs= -.318, p= .025). Conclusions: the greatest presence of omission of care falls on basic care interventions, human resource factors are ranked first so that the omission or delay of nursing care interventions occurs; however, only the factors of the material resource referral negatively related to the continuous assessment interventions.
Muslim female activism in social discourse of the republic of Tatarstan
Authors: Gibadullina Milyausha , Kusanova Dinara
Published: June 2021

Nowadays the stress turns from traditional forms of activism to new forms of it and mostly it is implemented in internet sphere. Today social nets become the place of formation and development of social discourse. In framework of this paper, several prominent Muslim female blogs in Instagram are examined. So contemporary Muslim women actively join in the information field, find their niche and ac- quire audience in social nets too. At the present point they represent themselves primarily as wives and mothers, thus they get social approval for being in public sphere. However, the example of contemporary Muslim bloggers tends to transform traditional conception of religious women and her behavioral pat- terns. Now Muslim women-bloggers do not make any statements, denoting their civil rights or political positions, generally they are oriented on female auditory. Their activity is an example of the way to imple- ment your right of appearance in public sphere, saving your religious identity.
Social and Psychological Climate and Party Political Preferences in the Nizhny Novgorod Region for the First Half of 2020: Peace and Justice
Authors:   Приволжский филиал ФНИСЦ РАН, Устинкин С. В. ,   ФМОЭУ НГЛУ им. Н. А. Добролюбова, Нижний Новгород, Россия, Кувакова И. М. ,   Институт социальных наук, Москва, Россия, Труфанов А. Ю. ,   Приволжский филиал ФНИСЦ РАН, Нижний Новгород, Россия, Самсонов А.И. ,   Приволжский филиал ФНИСЦ РАН, Нижний Новгород, Россия
Published: June 2021

The article summarizes the results of a sociological study of a multicolored palette of perceptions in the narrow sense of the world’s feelings of the population as influences of ideas expectations and hopes for the life of the regional community, considered through the prism of social changes A conclusion is drawn about the socio-psychological climate (optimism ) ideas about justice party and political preferences of society in Nizhny Novgorod and the Nizhny Novgorod region in the first half of 2020. The materials continue the series of studies 2015 – 2016 and are based on data from the Privolzhsky branch of the FCTIS RAS and the Institute of Social Management Problems Leniya of Nizhny Novgorod.
Social Justice and Human Rights in the Socio-Cultural Space of Russia
Authors:   ИСПИ ФНИСЦ РАН, Москва, Россия, Мчедлова Е. М.
Published: June 2021

The article considers, in particular, such political values as social justice and human rights, their place in the Russian socio-cultural space. The article presents the sociological data of the monitoring study conducted by the Center for the Sociology of Religion and Socio-Cultural Processes of the ISPI of the Russian Academy of Sciences in recent years in Moscow and some regions.
Interest of Moscow Youth in Non-Traditional Religions, Eastern Religions and Esoteric Teachings
Authors:   ИСПИ ФНИСЦ РАН, Дзуцев Х.В. ,   СОГУ им. К.Л. Хетагурова, Владикавказ, Россия, Дибирова А.П. ,   ИСПИ ФНИСЦ РАН, Москва, Россия, Корниенко Н.В. ,   ИСПИ ФНИСЦ РАН, Москва, Россия
Published: June 2021

This article presents the results of a study of the level of confidence of the population of the NCFD in the demonstration of their religious feelings by officials and their interaction with religious institutions. It also examines the degree of public confidence in informal leaders in their desire to demonstrate their commitment to religion with the help of ethno-religious instruments of influence on the North Caucasian society. The results of the analysis show that the level of trust of the residents of the North Caucasus Federal District to such manifestations by officials and informal leaders is low. The vast majority of the popu- 90 lation does not believe in the sincerity of these manifestations. At the same time, the respondents showed more unanimity in the negative answers than in the positive ones. There was no correlation between the respondents ' religious affiliation and their level of trust in politicians and informal leaders. In their assessments, respondents chose less categorical answers ("rather, I agree", "rather, I disagree"). Experts also more often said that the population of their republics is suspicious of the demonstrative display of religiosity by officials, and of the attempts of leaders of informal religious organizations to influence the population by using an ethno-religious tool.
Targeting breast cancer exosomes with nucleic aptamers: innovative tools for early diagnosis and therapy
Authors:   Consiglio Nazionale delle Ricerche (CNR), Esposito C.L. , Quintavalle C ,   Consiglio Nazionale delle Ricerche (CNR), Ingenito F ,   Consiglio Nazionale delle Ricerche (CNR), Rotoli D ,   Consiglio Nazionale delle Ricerche (CNR), Roscigno G ,   “Federico II” University of Naple, Nuzzo S ,   IRCCS SDN, Thomas R ,   Mediterranea Cardiocentro, Catuogno S ,   Consiglio Nazionale delle Ricerche (CNR), Minic Z ,   University of Ottawa, Berezovski M ,   University of Ottawa, Franciscis V ,   Consiglio Nazionale delle Ricerche (CNR), Condorelli G ,   Consiglio Nazionale delle Ricerche (CNR)
Published: June 2021

Exosomes are emerging as promising target for early diagnosis and therapy in diff erent oncological conditions including breast cancer (BC). However, the development of tools able to easily and specifi cally target cancer cell-derived exosomes still represent a fundamental issue that is required to realize their clinical utility. Nucleic-acid aptamers are a promising class of structured single stranded oligonucleotides that serve as high affi nity ligands of disease-associated proteins. Given their high potential in diagnosis and therapy, we addressed the development of aptamers specifi c for BC-derived exosomes. To this end, we developed a novel SELEX strategy by using exosomes purifi ed from primary BC cells as positive selection target. By such a strategy we isolated nuclease resistant RNA aptamers able to specifi cally discriminate BC-derived exosomes from those produced by normal cells. Th e best sequences were optimized identifying short molecules (about 30-35 mer) that was characterized as tools for exosome detection. Further, we demonstrated that the developed aptamers inhibited exosome cellular uptake antagonizing cancer exosome-induced cell migration. By proteomic approach we identifi ed possible targets that we are characterizing. Our results underline the great potential of isolated aptamers as tools for the development of innovative strategies for BC early diagnosis and therapy.
Addressed delivery of valproic acid to target cells in treatment of epilepsy using aptamers
Authors:   Professor V. F. Voino-Yasenetsky Krasnoyarsk State Medical University, Zamay T.N. , Dmitrenko D.V. ,   Professor V. F. Voino-Yasenetsky Krasnoyarsk State Medical University, Shnaider N.A. ,   Professor V. F. Voino-Yasenetsky Krasnoyarsk State Medical University, Narodova E.A. ,   Professor V. F. Voino-Yasenetsky Krasnoyarsk State Medical University, Narodova V.V. ,   Professor V. F. Voino-Yasenetsky Krasnoyarsk State Medical University, Usolceva A.A. ,   Professor V. F. Voino-Yasenetsky Krasnoyarsk State Medical University, Popov I.S. ,   Professor V. F. Voino-Yasenetsky Krasnoyarsk State Medical University
Published: June 2021

The aim of the research. To develop a drug based on aptamers that cross the blood-brain barrier, targeting the delivery of valproic acid to the brain. Material and methods. We used the Brain 1 and Co 451 aptamers passing through the blood-brain barrier, obtained using the in vivo-SELEX technology, the affi nity of which was determined using fl ow cytometry fl uorescence microscopy. Th e drug for targeted delivery of valproic acid was obtained using the conjugation of Konvulex, biotinylated aptamers, and streptavidin protein. Th e antiepileptic effi cacy of the drug was evaluated in ICR mice with a lithium-pilocarpine model of the development of epilepsy. Aft er the injection of pilocarpine, the animals were monitored using round-the-clock video recording. For the treatment of epilepsy, a valproic acid dose of 130 μg / g of animal weight was used. During treatment with a drug for targeted delivery, the dose of valproic acid was reduced to 5 μg / g. Evaluation of status epilepticus in mice was performed using the Racine Scale. Results. In animals, using the lithium-pilocarpine model, status epilepticus was formed at diff erent stages - from the 1st to the 5th. In all groups of animals, complete overcoming of status epilepticus did not occur in 120 min. In the group of mice treated with valroic acid, no change in their status occurred within 80 minutes. When mice were treated with conjugates based on the Brain 1 and Co 451 aptamers, the blockade of status epilepticus in mice, despite the lower (26 times) doses of the administered antiepileptic drug, occurred faster. Conclusion. A scientifi c platform has been developed for the development of drugs for targeted delivery of antiepileptic drugs with high effi ciency and low toxicity
Problems of implementation of personalized medicine in medical cosmetology in Russia
Authors:   Center of Collective Usage “Molecular and Cellular Technologies”, Borzykh O.B. , Petrova M.M. ,   Professor V. F. Voino-Yasenetsky Krasnoyarsk State Medical University, Shnayder N.A. ,   V.M. Bekhterev NMRC P.N, Nasyrova R.F. ,   V.M. Bekhterev NMRC P.N
Published: June 2021

At the present time, the 4P concept (predictive, preventive, personalised and participatory) is a prospective trend in development of clinical medicine. The concept is being actively introduced into diff erent medical specialities. However, the development of personalised approach in medical cosmetology as a speciality at the intersection of medical sciences (dermatology, maxillofacial surgery, plastic surgery, restorative medicine, general practice, psychiatry, clinical pharmacology, etc.) is at the stage of discussion. The concept of 4P medicine suggests, among other things, analysis of genetic risks and development of preventive procedures based thereon that would decrease the risk of cosmetological complications development. The review includes analysis of literature dated 2010-2020. The following databases in Russian and foreign languages were searched using the keywords and advanced search builders: E-Library, PubMed, Springer, Clinicalkeys, Google Scholar. In this paper, we introduce a novel compilation of the known gene polymorphisms that may be used for determination of the genetic risks in cosmetological patients.
20-years dynamics of tuberculosis and HIV mortality and of their contribution to life expectancy reduction in the population of Krasnoyarsk
Authors:   Prof. V. F. Voino-Yasenetsky Krasnoyarsk State Medical University, Narkevich A.N. , Vinogradov K.A. ,   Prof. V. F. Voino-Yasenetsky Krasnoyarsk State Medical University, Narkevich A.A. ,   Prof. V. F. Voino-Yasenetsky Krasnoyarsk State Medical University, Grjibovski A.M. ,   Northern state medical university
Published: June 2021

Aim of the study. To study the dynamics of mortality from tuberculosis and HIV as well as their contribution to life expectancy reduction in Krasnoyarsk Krai population over a period of 20 years. Material and methods. We used primary databases of Krasnoyarsk Krai population mortality for the period from 1999 to 2018. The direct method of standardisation according to the European standard of population age structure was applied for calculation of the standardised population mortality ratio. In order to analyse mortality in the population of the WHO European region and the CIS, the data of the European health information gateway were used (https://gateway.euro.who.int). Results. It has been established that female mortality from certain infectious and parasitic diseases has increased signifi cantly (from 13.2 to 22.7 per 100,000 of female population) in the cause of death structure of Krasnoyarsk Krai within the 20-years period. Analysis of Krasnoyarsk Krai mortality from such specifi c conditions as tuberculosis and HIV has shown signifi cant decrease in tuberculosis mortality rate which complies with the global trend in the dynamics of mortality from this disease, while the rate of reduction for this index surpasses that of CIS countries. Th e analysis has established signifi cant growth of HIV mortality in Krasnoyarsk Krai population, especially female (up to 11.6 per 100,000 of female population). Conclusion. There has been a change of the leading mortality cause in the structure of population mortality from certain infectious and parasitic diseases over the period of 2016-2017. From that moment, the leading role in the cause of death structure of Krasnoyarsk Krai in this class of causes belongs to HIV
Computational approach to design of aptamers to the receptor binding domain of SARS-CoV-2
Authors:   Federal Research Center ”Krasnoyarsk Science Center SB RAS”, Artyushenko P.V. , Mironov V.A. ,   Lomonosov Moscow State University, Morozov D.I. ,   University of Jyväskylä, Shchugoreva I.A. ,   Federal Research Center ”Krasnoyarsk Science Center SB RAS”, Borbone N ,   University of Naples Federico II, Tomilin F.N. ,   Siberian Federal University, Kichkailo A.S. ,   Federal Research Center ”Krasnoyarsk Science Center SB RAS”
Published: June 2021

The aim of the research. In this work, in silico selection of DNA-aptamers to the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein was performed using molecular modeling methods. Material and methods. A new computational approach to aptamer in silico selection is based on a cycle of simulations, including the stages of molecular modeling, molecular docking, molecular dynamic simulations, and quantum chemical calculations. To verify the obtained calculated results flow cytometry, fluorescence polarization, and small-angle X-ray scattering methods were applied. Results. An initial library consisted of 256 16-mer oligonucleotides was modeled. Based on molecular docking results, the only one aptamer (Apt16) was selected from the library as a starting aptamer to the RBD protein. For Apt16/RBD complex, molecular dynamic and quantum chemical calculations revealed the pairs of nucleotides and amino acids whose contribution to the binding between aptamer and RBD is the largest. Taking into account these data, Apt16 was subjected to the structure modifi cations in order to increase the binding with the RBD. Th us, a new aptamer Apt25 was designed. Th e procedure of 1) aptamer structure modeling/modifi cation, 2) molecular docking, 3) molecular dynamic simulations, 4) quantum chemical calculations was performed several times. As a result, four aptamers (Apt16, Apt25, Apt27, Apt31) to the RBD were designed in silico without any preliminary experimental data. Binding of the each modeled aptamer to the RBD was studied in terms of interactions between residues in protein and nucleotides in the aptamers. Based on the simulation results, the strongest binding with the RBD was predicted for two Apt27 and Apt31aptamers. The calculated results are in good agreement with experimental data obtained by flow cytometry, fluorescence polarization, and small-angle X-ray scattering methods. Conclusion. Th e proposed computational approach to selection and refi nement of aptamers is universal and can be used for wide range of molecular ligands and targets
The receptor-binding domain: aptamers (SARS-CoV-2) binding investigation by isothermal titration calorimetry
Authors:   University of Santiago de Compostela, Dominguez Arca V
Published: June 2021

The aim of the research. To optimize the calorimetry method, which allows to study the binding of the receptor-binding domain (RBD) protein of the coronavirus COVID-19 to aptamer 27 obtained using a computational method. Material and methods. Computational modeling and calorimetry methods were used to optimize the method. Results. Th e results showed that the calorimetry method makes it possible to assess the binding of the RBD protein to the aptamer. Conclusion. Th ese experiments will be run as soon as will be possible to determine the optimal conditions to functionalize gold substrates with the previously thiolated aptamers.
Structure approaches to study of DNA aptamers in solution
Authors:   Federal Research Center «Krasnoyarsk Science Center SB RAS», Moryachkov R.V. , Nikolaeva P.A. ,   Lomonosov Moscow State University, Spiridonova V.A. ,   Lomonosov Moscow State University
Published: June 2021

The high potential of aptamers – specifi c molecular agents based on short single-stranded nucleic acids – makes high demands on the molecules under development for the effi ciency of interaction with target biomolecules. In this work, approaches are considered for studying the spatial structure of DNA aptamers in solution using various complementary methods, which make it possible to obtain a more complete picture of the formation of the structure and conformational changes, to track the interaction with the target protein, the tendency to oligomerization, and to characterize the spatial structure of both individual molecules and complexes.
New aptamer-based approaches for the targeting of cancer associated fibroblast in NSCLC
Authors:   Endocrinology and Oncology “Gaetano Salvatore” (IEOS), National Research Council (CNR), Ciccone G , Ibba M.L. ,   “Federico II” University of Naples, Coppola G ,   “Federico II” University of Naples, Petrillo G ,   “Federico II” University of Naples, Catuogno S ,   Consiglio Nazionale delle Ricerche (CNR), Esposito C.L. ,   Consiglio Nazionale delle Ricerche (CNR)
Published: June 2021

The aim of the research. Non-small cell lung cancer (NSCLC) represents about 80 % of all lung cancer cases and is oft en associated with drug resistance, relapses and a poor prognosis. Th erefore, the identifi cation of eff ective therapeutic strategies represents a crucial challenge in oncology. A key limit of conventional anticancer treatments is that they do not target the permissive tumor microenvironment, of which key components are cancer‐associated fibroblasts (CAFs). It has been shown that CAFs are able to regulate malignant progression and drug resistance. However, a detailed characterization of CAF profile and the targeting of their pro-tumor eff ects still remain an ambitious challenge and have a primary importance for the identifi cation of new eff ective therapies. Material and methods. We aimed to develop innovative strategies based on nucleic acid aptamers to address these fundamental issues. Firstly, we applied an aptamer conjugate (named Gint4.T-STAT3), containing a STAT3 siRNA linked to an aptamer binding and inhibiting the PDGFRβ, to specifi cally silence STAT3 reported as a fundamental player in the cross-talk between CAFs and epithelial NSCLC cells. Results. We demonstrated that this molecule eff ectively delivers STAT3 siRNA in NSCLC cells, blocking CAF-induced cell growth and migration in both continous and primary NSCLC coltures. In addition, in order to address CAF specifi c targeting and profi ling, we developed an innovative diff erential cell-SELEX approach by using primary NSCLC CAFs as selection target. Such a strategy allowed the isolation of diff erent aptamers discriminating NSCLC CAFs from normal lung fi broblasts. Th e analyses of aptamer specifi city and functionality is curently ongoing. Conclusion. Our data represent the fi rst ever attempt in CAF targeting using aptamer-based drugs, and can open innovative horizons in the current therapeutic approaches forNSCLC.
Magnetomechanical stimulation of bone tissue regeneration
Authors:   Professor V. F. Voino-Yasenetsky Krasnoyarsk State Medical University, Zamay G.S. , Kolovskaya O.S. ,   Professor V. F. Voino-Yasenetsky Krasnoyarsk State Medical University, Grek D.S. ,   Professor V. F. Voino-Yasenetsky Krasnoyarsk State Medical University, Babkin V.A. ,   A.E. Favorsky Irkutsk Institute of Chemistry SB RAS, Neverova N.A. ,   A.E. Favorsky Irkutsk Institute of Chemistry SB RAS, Koshmanova A.A. ,   Siberian Federal University, Patc Yu.S. ,   Professor V. F. Voino-Yasenetsky Krasnoyarsk State Medical University
Published: June 2021

The aim of the research. To assess the ability of superparamagnetic nanoparticles functionalized with the RGD peptide to accelerate bone tissue recovery aft er transverse osteotomy under the infl uence of a low-frequency alternating magnetic fi eld. Material and methods. We used superparamagnetic nanoparticles ferroarabinogalactans (FeAG) functionalized with the RGD peptide for targeted binding to integrins. Th e model for assessing the ability of FeAG-RGD to accelerate bone regeneration was the transverse osteotomy of the radius of the ICR mice. To induce the process of bone tissue regeneration aft er the injection of FeAG-RGD particles, mice were placed in an alternating magnetic fi eld (50 Hz 100 Oe) for 60 min. Th e therapy was performed daily for 5 days. Results. Th e paper tested the hypothesis about the acceleration of bone tissue regeneration by the method of magnetomechanical therapy using superparamagnetic FeAG-RGD nanoparticles. It has been established that FeAG-RGD under conditions of an alternating magnetic fi eld (50 Hz 100 Oe) are able to change their orientation in space and, thus, cause mechanical stress in the proteins of the cell membrane – integrins, which trigger the process of osteogenic diff erentiation. Th e research results showed that 5 procedures of magnetomechanical therapy lead to complete restoration of bone tissue at the site of the transverse osteotomy, while in the group of control animals no fusion of bones is observed. Conclusion. Th e use of the method of magnetomechanical therapy using ferroarabinogalactans functionalized with the targeting ligand RGD for binding to integrins of osteogenic cells is a promising technology for bone tissue regeneration
Synthesis, properties and functionalization of gold nanostars for medical diagnostics
Authors:   Federal Research Center “Krasnoyarsk Science Center of the Siberian Branch of the Russian Academy of Sciences”, Smoliarova T.E.
Published: June 2021

Th e aim of the research. To evaluate two approaches to colloidal synthesis using two diff erent non-toxic surfactants (PVP and Triton X-100) and their properties for future use. Material and methods. (PVP) Th e solution of GNSs with short tips was prepared in 200 ml vial. 20 mg of PVP (Polyvinylpyrrolidone, 1-ethenylpyrrolidin-2-one) were dissolved in the 200 mL of DMF (N,N-Dimethylmethanamide) (with the sonication to dissolve well). (Triton X-100) In a typical preparation of GNSs with long tips, the seed solution was prepared in a 20mL vial: 5mL of HAuCl4 5∙10-4M in water are added to 5mL of an aqueous solution of TritonX-100 0.1M. To examinate the shape and properties of prepared gold nanostars Cary 100 Bio Spectrophotometer using quartz cuvettes was used to taken on UV-Vis spectra. Transmission Electron Microscopy (TEM) was used to obtain shape and size of prepared GNSs. Results. Microscopy analysis shows that the obtained GNSs have completely diff erent shapes. Th e GNSs fabricated using synthesis approach with PVP have shorter tips and the cores are larger than the GNSs synthesized with Triton X-100 synthesis approach. TEM-images of the second ones show smaller size nanoparticles with the longer and thinner tips. Optical properties of the synthesized GNSs were analyzed using UV-vis-NIR absorbtion spectra, which shows maximum plasmon existence at 800 nm for GNSs synthesized with PVP and at 850 nm for GNSs synthesized with Triton X-100. Conclusion. In summary, we developed GNSs using two colloidal synthesis approaches with the use of two diff erent non-toxic surfactants (PVP and Triton X-100). In the future, gold nanostars are planned to be used to develop highly sensitive methods of medical diagnostics.
Ethos of Science
Authors:   Bauman Moscow State Technical University, Gubanov N.N. , Gubanov N.I. ,   Tyumen State Medical University, Klimina L.V.
Published: June 2021

Analyzed is the problem of principles of scientific ethos in educational environment of university. At present, as a result of the activation of youth (student, master's and postgraduate) science — our scientific future — it is important to instill in people entering science the principles of the scientific ethos, which make it possible to build productive relationships within the scientific community, as well as between the scientific community and society. Of course, the topic “Science and Ethics” is relevant for mature scientists as well. The article is a brief outline of the ethics of science as one of the areas of applied ethics. The 4 norms of the scientific ethos of CUDOS proposed by R. Merton are considered: Communalism: the belief about the common heritage of scientific knowledge; Universalism: assessment of the truth of the provisions should be independent of titles, gender, age, race of scientists; Disinterestedness: the primary stimulus of a scientist’s activity is a disinterested search for truth; Organized Skepticism: Organized skepticism, the duty of the scientist is to objectively assess the soundness of what his colleagues have done and the reliability of his results. Using the golden rule of morality, additional norms have been formulated: not to commit plagiarism; do not falsify data; not to interfere with the publication of the works of opponents; 8) not hush up arguments that contradict their concept; prevent undeserved co-authorship; in the references, cite only works related to the essence of the problem; fairly evaluate the contribution of employees to the overall work; it is inadmissible to present a compilation instead of a scientific work; not to publish papers on a problem in which you do not have sufficiently complete information; give an adequate assessment of the work of colleagues; do not sell their authorship; be humble and respect opponents; and be intolerant of violation of the norms of the scientific ethos by others. In the context of the development of applied science and its commercialization, a tendency arose to abandon the Merton norms. The norms of the PLACE system by J. Ziman are described (property rights, patents; solving local problems; setting the research goal by authoritarian authorities; work to order; work of a limited circle of experts). When abandoning Merton’s norms, the peculiarities of fundamental and applied science are not taken into account. The article shows that Merton norms and additional norms apply to classical science and modern fundamental science. Ziman highlighted norms, as well as additional norms refer to applied science. Additional norms apply to both fundamental and applied science, and these are general norms of modern science. It is suggested that on the basis of the convergence of fundamental and applied research, a single ethos of science can be formed.
Philosophy of technique as a component part of philosophy curriculum
Authors:   Bryansk State Technical University, Popkova N.V.
Published: June 2021

Analyzed are principal problems of lecturing philosophy of technique in the Higher education. Shown is that the traditional understanding of technique as a tool not explains adequately the autonomy of technique characteristic of modern epoch and its transforming impact on society. In the article various modern approaches to the philosophical analysis of technique are considered. For example, a concept is disclosed that understands technical progress as a stage of global evolution. Developed by modern science, the concept of global evolutionism allows us to see the similarity between the processes of nature change, characteristic for living matter and for technical reality. According to another concept, the forms and methods of creation and development of technical objects existing in a given society are socially: technical progress is determined by social mechanisms, and the functioning of the social system can be understood as technology and analyzed with the help of concepts developed for technique analysis. It is shown that the theoretical models and practical recommendations obtained depend on the understanding of technique: there are different views on its essence. It is concluded that further philosophical search is necessary, since different views on technique become as a basis for opposing programs to exit from the current environmental crisis.
Methods of teaching philosophy in a modern Technical University: “challenges” and “answers” in the paradigm of the competence-based approach
Authors:   Ural State University of Railway Transport, Pyatiletova L.V.
Published: June 2021

Analyzed is the problem of teaching philosophy at a modern technical university: the place and significance of philosophy in the university cycle of disciplines, its genetic connection with the mission of the university. The relevance of this problem and the search for answers to the challenges of the time sharply raises the question that is latently present within the competence-based approach implemented in the modern educational space — about effective methods of teaching philosophy as an academic discipline within the framework of a technical university in close connection, taking into account the characteristics of students - course participants, representatives of technical areas of study that have a certain specificity of the perception of social and humanitarian knowledge. The article reveals the potential of such discipline teaching methods as Socratic and Pragmatic, the active use of which opens up prospects for a new ontology of university philosophy: as an anthropological practice of the Other, a practice that organically absorbs the utilitarian expectations from studying the content of the university discipline “Philosophy” by students of technical specialties.
Strategies for coping student behavior in difficult life situation
Authors:   Saint Petersburg State Institute of Psychology and Social Work, Musina V.P.
Published: June 2021

Examined are features of behavior of students of paid division of university in difficult life situations (using the example of the economic crisis). Empirically, the specificity of relationships between severity of the various components of resilience, stress tolerance, and strategies for matching behavior in the face of life difficulties was revealed. Recommendations on provision of psychological assistance to students in difficult life situations are presented.
Ecological aspects of physical and mathematical training of students of modern college under conditions of globalization as pre-requisite for development of cognitive activity
Authors:   National Research University “Higher School of Economics”, Ashikhmina E.A. , Svetlova O.A. , Petrov E.E.
Published: June 2021

Examined is the role of ecological environmental component of physical and mathematical training, that determines the responsibility of professional activity in the context of development under conditions of high-tech economy. The analysis of the state of physical and mathematical training is given, the role of ecological aspects of physical and mathematical training of students of modern college in development of cognitive activity occurring in the context of globalization is shown, that mechanisms of increasing ecological culture of students of modern college are revealed.
Evaluation of educational product by students as criterion of real Image of University
Authors:   Rostov State University of Economics (RINH), Khachaturyan N.R.
Published: June 2021

Analyzed are behavior of applicants before and after entering the university, as well as forms of image of the university based on real perception in the context of the educational process. Modern universities are focused on attracting as many applicants as possible, since this has become a criterion for evaluating universities against the background of competitors. The positioning and promotion of the university is based on the rather ephemeral concept of “image”. The image at the stage of admission is reinforced by the constants set by the university, which after the applicant's admission become phantom and have no direct relation to the educational process, the prestige of the university, or the prospective employment in the labor market. The research process was provided by sending a personal questionnaire, compiled in Google, to the contacts of groups of students and teachers of the Rostov State University of Economics (Rostov-on-Don). The final conclusions are based on the generalization of the participants ' responses, their collective discussion, and the development of an algorithm for structural analysis of the real and virtual advantages of the university that affect the formation of a favorable image of the university in the minds of its audience.
About the measures of preparing the medical personals and its results in Uzbekistan
Authors:   Samarkand State University, Djumanov S.A.
Published: June 2021

Researched are problems of training medical specialists for the system of public health in Republic of Uzbekistan. It’s known that the place of the medical personals which have high qualification in the works of the quality medical caring to people is important. For this reason, the preparing works of the medical personals were carried out in Uzbekistan during independence years. In the result of these measures, a number of positive results were achieved. This article is devoted to the measures of training the medical personals in Uzbekistan and its results.
Principal factors, influencing economic re-organization in the Soviet State in the NEP period
Authors:   South-West State University, Kartamysheva N.V. , Dolzhenkova E.V.
Published: June 2021

Examined is the historical experience of our country, which in the difficult post-war years took the path of transformations and reforms, later they became an impetus for progress and development. The aim of the article is to identify the reasons, conditions, results and results of economic transformations during the NEP period. Highlighted are the main areas of activity of the Soviet state in the framework of economic reforms during the NEP period. In the process of writing the article, the historical-theoretical method was used. In addition, general scientific methods were applied, i.e. analysis, synthesis, comparison, generalization, the method of an integrated approach and others. This article analyzed the economic reforms carried out by the Soviet state during the New Economic Policy and summed up the results of these reforms. In addition, the factors influencing economic transformations were identified, and the successes and failures that the Bolshevik authorities had to face on the path of economic reforms during the NEP were considered. The authors conclusion is made, that the results of the New Economic Policy include the emergence of financially independent enterprises, overcoming the state budget deficit, the formation of the ruble as a hard convertible currency and the formation of the Soviet credit system. At the same time, the NEP was characterized by the rejection of the harsh methods of war communism and attempts to establish market relations. However, the bureaucratic leadership, which did not accept this relationship, remained.
Productivity of Vannamei Shrimp Cultivation (Litopenaeus vannamei) in Intensive Ponds in Tegal City, Central Java Province
Authors: Muchtar Muchtar , Farkan Mochammad , Mulyono Mugi
Published: June 2021

The failure of tiger shrimp (Penaeus monodon) farming could make farmers stop their cultivation activities. As an alternative, vannamei shrimp cultivation gives hope for productive, profitable, and sustainable cultivation. The development of shrimp farming in Tegal City is carried out through simple methods, intensive technology, and the use of Busmetik technology or mini-scale shrimp farming on plastic ponds. The high demand in the shrimp market continues to encourage farmers to increase their productivity by increasing stocking density. The purpose of this study is to determine the performance of vannamei shrimp cultivation which is cultivated intensively including yields, survival rate (SR), feed conversion ratio (FCR), and shrimp growth in Tegal City, Central Java Province. The research was conducted from July to October 2019. The research method used was a case study with 16 plots of ponds, and the average area of the pond was 1000 m². Based on the results of the calculation, it can be seen that the average yield is 1,603 kg per pond with a stocking density of 100 fish/m², a survival rate (SR) is 85.6%, a feed conversion ratio (FCR) is 1.41 and the shrimp growth is 0.16 grams per day. Economically, based on the Benefit-Cost Ratio (B/C ratio) of 1.46, vannamei shrimp cultivation in Tegal City is profitable so that shrimp farming can be carried out sustainably.
Profitability Analysis of Tiger Grouper Hatchery (Epinephelus fuscoguttatus) Household Scale in Kelatakan Village, Situbondo, East Java
Authors: Palupi Mustika , Fitriadi Ren , Dadiono Muh Sulaiman , Yonarta Danang , Kusuma Rima Oktavia
Published: June 2021

The development of tiger grouper cultivation technology has not been maximally implemented so that the survival rate of fish is very low. The result is that it is very vulnerable to losses in cultivation. This study aims to analyze the profitability of tiger grouper hatchery. The research method used is a case study. Primary data is collected through observation, interviews, and questionnaires. Secondary data is data obtained indirectly. The calculated data analysis is the Benefit-Cost (B/C) Ratio, Break-even Point Analysis and Profitability. The results obtained are BEP in units is 170,606 heads and BEP in price is IDR 1,709,750, B/C Ratio is 1.65, and the payback period is 5 years 2 months.
Effect of Sodium Chloride Concentration on Aeromonas hydrophila, Proximate and Organoleptic Analyses in Catfish (Clarias sp.) Flesh
Authors: Wardani Dian Wahyu , Purnama Abdul Mulki , Kartikaningsih Hartati , Jaziri Abdul Aziz
Published: June 2021

Intensive aquaculture on catfish (Clarias sp.) has been getting problem due to pathogenic bacteria such as Aeromonas hydrophila. Fish infected by A. hydrophila would bear various symptoms, including hemorrhagic on the skin, gills, ulcers, and pale skin color. To tackle this situation, salt (sodium chloride) treatment with different concentrations can be used, which acts as both bactericidal and bacteriostatic agents. This study aimed to determine the effect of different salt concentration (viz. 0%, 5%, 10% and 15%) added in the treated samples by evaluating the availability of pathogenic bacteria using total plate count (TPC) and total A. hydrophila, along with proximate and organoleptic assessment. An experimental method was used in this research with a completely randomized design (CRD). The results showed that the TPC value in all sample treatments was higher (around 5 × 105) than that recommended by Indonesia National Standard (SNI). On the other hand, the sample added 10% and 15% salts exhibited a significant effect on the decrease of A. hydrophila through a selective medium Rimler-Shotts agar. For proximate analysis, the treated samples contained in the ranges of 67.33-80.03% (WB), 0.91-13.58% (WB), 35.06-69.92% (DW) and 4.41-1451% (DW) of moisture, ash, crude protein, and fat, respectively. In addition, a sensory test of catfish flesh samples showed that all parameter tests, including mucus, odor, and texture met the referred standard. Taken together, this study may contribute to developing an approach in treating pathogenic bacteria during rearing and also post-harvesting catfish; however, further research is required to obtain a better outcome in dealing with food safety issues.
Determination of the Toxicity Cause by Trace Metals on Zebrafish (Danio rerio) Embryo
Authors: De Silva D.P.N. , Fasmina M.F.A. , Jayamanne S. C. , Liyanage N.P. P. , Perera J.L.C.S.
Published: June 2021

Water quality deterioration due to inorganic and organic pollutant is a serious issue and the presence of toxic trace metals cause a serious threat to the aquatic ecosystem. Fish embryos have gained interest in risk assessment because of their high sensitivity to pollutants and the ecological relevance. This study investigated the acute toxicity effect of trace metals Arsenic (As), Cadmium (Cd), Mercury (Hg), Lead (Pb), Copper (Cu) and Zinc (Zn) on zebrafish (Danio rerio) embryo. Embryos were exposed to ten different concentrations of individual trace metals and lethality rate was recorded at 24, 48, 72 and 96 hours based on the coagulation of fertilized egg, lack of somite formation, lack of detachment of the tail and lack of heart beat. The results indicated a significant difference between the control and trace metal treated embryo (P< 0.05) and higher mortality rate along the increase of trace metal concentration. Along with the increase of exposure time for Cu, Zn and As, the  mortality rate became slower. Sub-lethal and teratogenic deformities such as growth retardation, lack of tail development, lack of eye lens (placode), yolk sac edema, pericardial edema, hemorrhages, shrinkage of chorion and scoliosis were observed in most of the trace metal treated embryos. The results showed the toxic effects to aquatic biota due to trace metals emphasizing the usefulness of zebrafish embryo model for integrated biological hazard assessment.