bluuebunny/crossref_metadata_2025 huggingface dataset:
Fractional-Order Boosted Jellyfish Search Optimizer with Gaussian Mutation for Income Forecast of Rural Resident
Authors: Lei Yang , Fan Lingyun , Yang Juntao , Si Wenhu
Published: June 2022

The disposable income of residents can reflect the living standard of people in the area. For government departments, it is necessary to master the trend of rural resident income to formulate corresponding policies benefiting farmers. Thus, this paper proposes a grey model with an improved jellyfish search optimizer to predict the rural resident income in Shaanxi Province. Firstly, by applying fractional-order modified strategy and Gaussian mutation mechanism to the original algorithm, the proposed algorithm shows better performance in solving accuracy, stability, and convergence acceleration when compared with different classical methods on cec2017 and cec2019 test functions. Then, based on the fractional time-delayed grey model, a discrete fractional time-delayed grey model with triangular residual correction (TDFTDGM) is proposed by replacing the derivative with a first-order difference and introducing the triangular residual correction functions. Finally, the improved jellyfish search optimizer is used to explore the optimal order of the TDFTDGM model. The all-around performance of the forecast model is incomparable to additional grey models compared on four measure criteria, which means it is a practical approach for long-term prediction with small samples. Moreover, the forecast data of rural resident income in Shaanxi Province from 2021 to 2025 are given for reference.
Pulmonologist-Administered Balanced Propofol Analgosedation during Interventional Procedures: An Italian Real-Life Study on Comfort and Safety
Authors: Maffucci Rosalba , Maccari Uberto , Guidelli Luca , Benedetti Lucia , Fabbroni Roberto , Piccoli Bruno , Bianco Andrea , Scala Raffaele
Published: June 2022

Propofol-based sedation provides faster recovery than midazolam-based regimens with similar safety and comfort during video flexible bronchoscope (VFB) procedures. Pulmonologist-administered propofol “balanced” analgosedation (PAP-BAS) is still debated in Italy. In this real-life study, PAP-BAS safety and comfort during VFB procedures were investigated. We analysed prospectively the subjects undergoing elective VFB procedures in the Pulmonology and RICU of Arezzo Hospital between February and July 2019. PAP-BAS combined low propofol and meperidine doses titrated to achieve an RASS score between 0 and −3. The primary end-point was the complications’ rate. Secondary end-points were as follows: the relation between propofol’s dose and a subject’s comfort assessed with a VAS, recovery time according to a modified Aldrete score ≥9, RASS, and subjects’ will of undergoing the procedure again. We collected postprocedure symptoms’ intensity too. Our 158 study patients (67 years; SD ± 14; 64% males) incurred in 25% of complication, fully resolved with medical therapy. Neither recourse to ventilator support nor death was reported. Intraprocedural comfort was good (94% of VAS score ≤2). Among postprocedural symptoms, cough was the most frequently reported, in 36% of the cases. Although half of subjects remembered the procedure, 90% of them would have repeated it, if necessary. 85% of them recovered from procedures within 10 minutes. Complications, VAS, and recovery time were not correlated with propofol dose. To our knowledge, this is the first Italian study showing that PAP-BAS to perform a VFB procedure is safe, well tolerated with a quick recovery. Randomised controlled trials are warranted to confirm these preliminary results.
Reinforcement Learning with Probabilistic Boolean Network Models of Smart Grid Devices
Authors: Rivera Torres Pedro Juan , Gershenson García Carlos , Sánchez Puig María Fernanda , Kanaan Izquierdo Samir
Published: June 2022

The area of smart power grids needs to constantly improve its efficiency and resilience, to provide high quality electrical power in a resilient grid, while managing faults and avoiding failures. Achieving this requires high component reliability, adequate maintenance, and a studied failure occurrence. Correct system operation involves those activities and novel methodologies to detect, classify, and isolate faults and failures and model and simulate processes with predictive algorithms and analytics (using data analysis and asset condition to plan and perform activities). In this paper, we showcase the application of a complex‐adaptive, self‐organizing modeling method, and Probabilistic Boolean Networks (PBNs), as a way towards the understanding of the dynamics of smart grid devices, and to model and characterize their behavior. This work demonstrates that PBNs are equivalent to the standard Reinforcement Learning Cycle, in which the agent/model has an interaction with its environment and receives feedback from it in the form of a reward signal. Different reward structures were created to characterize preferred behavior. This information can be used to guide the PBN to avoid fault conditions and failures.
Comparative Study of Antiproliferative Activity in Different Plant Parts of Phaleria macrocarpa and the Underlying Mechanism of Action
Authors: Christina Yuyun Ika , Rifa’i Muhaimin , Widodo Nashi , Djati Muhammad Sasmito
Published: June 2022

Phaleria macrocarpa is a medicinal plant widely used in Indonesian folk medicine to treat several diseases, including cancer. However, the comparative evaluation of various plant parts of P. macrocarpa has not been studied for their anticancer properties on breast cancer. The study aimed to assess the antiproliferative activity of the ethanol extract of various parts of Phaleria macrocarpa against T47D human breast cancer cell lines. Several parts of P. macrocarpa, including pericarp, mesocarp, seed, and leaf, were used to determine the most potent plant part to inhibit the growth of T47D cells. The cytotoxic effects of each plant part were evaluated by WST-1 assay. The apoptotic level of T47D cells was determined by annexin V-FITC-PI and DNA fragmentation assay. Propidium iodide staining and the CFSE assay were used to examine the effect of each extract on cell cycle distribution and cell division, respectively. The relative number of caspase-3, Bax, and Bcl-2 was analyzed by flow cytometry technique. WST-1 assay revealed that P. macrocarpa leaves exhibited the most potent antiproliferative activity (p<0.05) compared to other plant parts with selectivity only to T47D cells. P. macrocarpa leaves extract effectively induced apoptosis, inhibited proliferation, and arrested the cell cycle of T47D cells. The relative number of caspase-3 was significantly (p<0.05) increased after being treated with P. macrocarpa leaf extract. P. macrocarpa leaf extract also leads to the dose-dependent accumulation in the Bax/Bcl-2 ratio due to upregulation of Bax and downregulation of Bcl-2. The overall results indicated that P. macrocarpa leaves could inhibit the proliferation of T47D cells and trigger apoptosis through caspase-3 activation and Bax/Bcl regulation. Therefore, P. macrocarpa leaves can be used for breast cancer therapy.
A Low Computational Cost Method for Mobile Malware Detection Using Transfer Learning and Familial Classification Using Topic Modelling
Authors: Acharya Saket , Rawat Umashankar , Bhatnagar Roheet
Published: June 2022

With the extensive use of Android applications, malware growth has been increasing drastically. The high popularity of Android devices has motivated malware developers to attack these devices. In recent times, most researchers and scholars have used deep learning approaches to detect Android malware. Although deep learning techniques provide good accuracy and efficiency, they require high computational cost to train huge and complex data sets. Hence, there is a need for an approach that can efficiently detect novel malware variants with a minimum computational cost. This paper proposes a novel framework for detecting and clustering Android malware using the transfer learning and the topic modelling approach. The transfer learning approach minimizes new training data by transferring well-known features from a qualified source model to a destination model, and hence, a high amount of computational power is not required. In addition, the proposed framework clusters the detected malware variants into their corresponding families with the help of Latent Dirichlet Allocation and hierarchical clustering techniques. For performance assessment, we performed several experiments with more than 50K Android application samples. In addition, we compared the performance of our framework with that of similar existing traditional machine learning and deep learning models. The proposed framework provides better accuracy of 98.3% during the classification stage by using the transfer learning approach as compared to other state-of-the-art Android malware detection techniques. The high precision value of 98.7% is obtained during the clustering stage while grouping the obtained malicious applications into their corresponding malware families.
Antitrypanosomal and Anthelminthic Properties of Ethanol Extracts of Carica papaya Linn. and Ceiba pentandra (L) Gaertn.
Authors: Wahab Obeng Ahmed , Boakye Yaw Duah , Agana Theresa Appiah , Boamah Vivian Etsiapa , Oppong-Kyekyeku James , Brobbey Abena Amponsaa , Adu Francis , Gbedema Stephen Yao , Agyare Christian
Published: June 2022

The most common diseases that affect low-income countries are helminthosis and trypanosomosis. In Ghana, and in many other African countries, herbal treatment of various diseases is still common. In the present study, we sought to determine the antitrypanosomal and anthelminthic activities of Carica papaya and Ceiba pentandra. The ethanol extracts of Carica papaya stem bark (PPSe) and leaves (PPLe) and ethanol extracts of Ceiba pentandra stem bark (CPSe) and leaves (CPLe) were screened against Trypanosoma brucei brucei and Pheretima posthuma worms in vitro. CPSe exhibited strong antitrypanosomal activity, while the other extracts exhibited moderate activity against T. b. brucei. All the extracts showed weak selective indices (SI) when tested on Jurkat cell lines, which is indicative of a potential toxic effect. When the extracts were screened against P. posthuma worms, only PPSe and CPSe were able to kill the worms after the exposure time at concentrations of 2.5, 5, and 10 mg/mL. PPSe was again the only extract that potentiated the anthelminthic activity of albendazole against P. posthuma worms. Preliminary phytochemical screening and GC-MS analysis revealed the presence of compounds with antitrypanosomal and anthelminthic properties. The results confirmed the potential of C. papaya and C. pentandra as remedies for trypanosomosis and helminthosis and also gives credence to their folkloric use.
Tropomyosin Is Potential Markers for the Diagnosis and Prognosis of Bladder Cancer
Authors: Yan Yunkun , Li Jianchang , Ye Mushi , Li Zhuo , Li Sining
Published: June 2022

Objective. To investigate the correlation between tropomyosin (TM) and clinical characteristics of bladder cancer. In addition, the relationship between TM and immune cell infiltration in bladder cancer was further analyzed. Methods. Based on The Cancer Genome Atlas (TCGA) database, the relationship between TM expression and clinicopathological features in bladder cancer was analyzed. Receiver operating characteristic (ROC) curve was used to evaluate the value of TM as a diagnostic marker for bladder cancer. Univariate and multivariate Cox regression was used to analyze the independent factors affecting the prognosis of patients with bladder cancer. The relationship between TM and immune cell infiltration was analyzed. Results. ROC curve showed that TPM1, TPM2, and TPM3 had significant diagnostic ability (AUC was 0.845, 0.848, and 0.873, respectively). The high expression of TPM1 and TPM2 is associated with poor overall and disease-specific survival in patients with bladder cancer (

P
<
0.05

). Multivariate Cox analysis showed that age and TPM1 were independent prognostic factors. The expression levels of TPM1, TPM2, TPM3, and TPM4 in low grade bladder cancer were lower than those in high grade bladder cancer (

P
<
0.05

). TPM1 and TPM2 are positively correlated with the infiltration of macrophages and NK cells in bladder cancer. TPM3 is positively associated with Th2. TPM4 is positively correlated with Th1 cells, macrophages, and neutrophils (

P
<
0.05

). Conclusions. TPM1 and TPM2 are effective markers for the diagnosis of bladder cancer. TPM1 is an independent prognostic factor for bladder cancer. TM is also associated with the infiltration of various immune cells in bladder cancer. TM may have influenced the development of bladder cancer through immune inhibition.
Long‐Term Dynamic Behavior of a Higher‐Order Coupled Kirchhoff Model with Nonlinear Strong Damping
Authors: Lv Penghui , Liu Yan , Yu Shasha
Published: June 2022

In this paper, we study the long‐time dynamics problem of a class of higher‐order Kirchhoff coupled systems with nonlinear strong damping. The existence and uniqueness of the solutions of these equations in different spaces are proved by prior estimation and Faedo–Galerkin method; secondly, the family of global attractors of these problems is proved by using the compactness theorem. The results of the Kirchhoff coupled group are promoted through research.
Effects of Disinfection Methods on the Color Stability of Precolored and Hand-Colored Maxillofacial Silicone: An In Vitro Study
Authors: Chotprasert Natdhanai , Shrestha Binit , Sipiyaruk Kawin
Published: June 2022

Maxillofacial prostheses are used in rehabilitation of patients with facial defects. Typically, these prostheses are fabricated with medical grade silicone and are tinted corresponding to the patients’ natural skin color. However, exposure to environment and disinfectants can result in color changes. This study aimed to evaluate the effects of four different disinfection methods on the color stability of precolored and hand-colored maxillofacial silicones. Forty specimens each of precolored and hand-colored silicone were prepared. The specimens were randomly divided into eight groups (n = 10) and cleansed with four different disinfection methods. Disinfection was carried out six times/day for 60 days, simulating once-a-day disinfection for a year. Color evaluation was carried out at day 0 and day 60 using a UV-vis spectrophotometer. Color alterations were calculated by the CIE

L

∗

a

∗

b

∗

system. Data were analyzed by two-way ANOVA with post hoc Tukey HSD and t-tests (α = 0.05). Disinfectants can affect the color stability of maxillofacial silicone. In our study, chlorhexidine solution and liquid soap resulted in the highest color change. Precolored silicone showed higher color stability than its hand-colored counterpart.
Intelligent Analysis and Classification of Piano Music Gestures with Multimodal Recordings
Authors: Chang Xunyun , Peng Liangqing
Published: June 2022

In the traditional recording system, recording any music includes a sizeable instrumental setup and allocates space for the music players. Lighter and fewer devices are replacing larger instruments due to technological advancement and epidemic environmental conditions. This research focuses on text, but audio and video types are also considered. Multiple signal classification with a 5G-based wireless communication network algorithm is implemented to perform the automatic recording and classification of the music data. In this research, a multi-modal gesture recognition dataset is considered for analysis. The dataset was obtained using sensor networks and an intelligent system to record the musical gestures and classify the recorded gestures. The development of machine learning algorithms is not limited to similar technological concepts. Still, it extends to almost all other technical resources such as the 5G network, signal processing, networking, and all other technical resources. This would lead to additional engineering challenges that are utilized in most cases, such as the development of gestures with multi-mode recording. This research has proposed MSA with WCN algorithm to perform intelligent analysis and classification of piano music gestures and is compared with the existing K-Means algorithm and achieved an accuracy of 99.12%.
Exploration of the Molecular Mechanism of Danzhi Xiaoyao Powder in Endometrial Cancer through Network Pharmacology
Authors: Li Lanyu , Yang Lukai , Liu Fang , Qu Jinfeng
Published: June 2022

Endometrial cancer (EC) is a common malignant tumor of the female reproductive system. Current treatments such as surgery and long-term hormone therapy are ineffective and have side effects. Danzhi Xiaoyao powder (DXP) can inhibit the growth of EC cells and induce apoptosis, but the pharmacological and molecular mechanisms of anticancer effects are still unclear. In this study, active components and potential targets of DXP were obtained from public databases. Protein effects and regulatory pathways of common targets were analyzed by protein-protein interaction (PPI), GO and KEGG. The results of network pharmacology showed that there are 87 common targets between EC and DXP. GO enrichment analysis showed that these targets were associated with response to oxidative stress, response to nutrient levels, hormone receptor binding and nuclear hormone receptor binding, etc. The results of KEGG analysis indicated that IL-17, TNF, PI3K/AKT, and RAS/RAF/MEK/ERK (ERK) signaling pathway were enriched in the anti-EC of DXP. Additionally, we cultured HEC-1B and KLE cells for validate experiments. DXP showed an inhibition of proliferation, migration, and cell cycle of both cells. Moreover, the expression of RAS, p-RAF, p-MEK, ERK, and p-ERK related proteins were downregulated. In conclusion, DXP might inhibit the proliferation of EC cells via apoptosis. Furthermore, DXP-induced inhibition of EC development might involve RAS/RAF/MEK/ERK pathway.
Constitutive Activation of the Tumor Suppressor p53 in Hepatocytes Paradoxically Promotes Non–Cell Autonomous Liver Carcinogenesis
Authors: Makino Yuki , Hikita Hayato , Fukumoto Kenji , Sung Ji Hyun , Sakano Yoshihiro , Murai Kazuhiro , Sakane Sadatsugu , Kodama Takahiro , Sakamori Ryotaro , Kondo Jumpei , Kobayashi Shogo , Tatsumi Tomohide , Takehara Tetsuo
Published: June 2022

In chronic liver diseases (CLD), p53 is constitutively activated in hepatocytes due to various etiologies as viral infection, ethanol exposure, or lipid accumulation. This study was aimed to clarify the significance of p53 activation on the pathophysiology of CLDs. In Kras-mutant liver cancer model, murine double minute 2 (Mdm2), a negative regulator of p53, was specifically deleted in hepatocytes [Alb-Cre KrasLSL-G12D Mdm2fl/fl (LiKM; KrasG12D mutation and Mdm2 loss in the liver)]. Accumulation of p53 and upregulation of its downstream genes were observed in hepatocytes in LiKM mice. LiKM mice showed liver inflammation accompanied by hepatocyte apoptosis, senescence-associated secretory phenotype (SASP), and the emergence of hepatic progenitor cells (HPC). More importantly, Mdm2 deletion promoted non–cell autonomous development of liver tumors. Organoids generated from HPCs harbored tumor-formation ability when subcutaneously inoculated into NOD/Shi-scid/IL2Rγ (null) mice. Treatment with acyclic retinoid suppressed growth of HPCs in vitro and inhibited tumorigenesis in LiKM mice. All of the phenotypes in LiKM mice, including accelerated liver tumorigenesis, were negated by further deletion of p53 in hepatocytes (Alb-Cre KrasLSL-G12D Mdm2fl/fl p53fl/fl). Activation of hepatic p53 was noted in liver biopsy samples obtained from 182 patients with CLD, in comparison with 23 normal liver samples without background liver diseases. In patients with CLD, activity of hepatic p53 was positively correlated with the expression of apoptosis, SASP, HPC-associated genes and tumor incidence in the liver after biopsy. In conclusion, activation of hepatocyte p53 creates a microenvironment prone to tumor formation from HPCs. Optimization of p53 activity in hepatocytes is important to prevent patients with CLD from hepatocarcinogenesis.

Significance:

This study reveals that activation of p53 in hepatocytes promotes liver carcinogenesis derived from HPCs, which elucidates a paradoxical aspect of a tumor suppressor p53 and novel mechanism of liver carcinogenesis.

See related commentary by Barton and Lozano, p. 2824
WEE1 Inhibition Augments CDC7 (DDK) Inhibitor–induced Cell Death in Ewing Sarcoma by Forcing Premature Mitotic Entry and Mitotic Catastrophe
Authors: Martin Jeffrey C. , Sims Jennie R. , Gupta Ajay , Bakin Andrei V. , Ohm Joyce Ellen
Published: June 2022

Ewing sarcoma is an aggressive childhood cancer for which treatment options remain limited and toxic. There is an urgent need for the identification of novel therapeutic strategies. Our group has recently shown that Ewing cells rely on the S-phase kinase cell division cycle 7 (CDC7) DBF4-dependent kinase (DDK) to maintain replication rates and cell viability and that DDK inhibition causes an increase in the phosphorylation of CDK1 and a significant delay in mitotic entry. Here, we expand on our previous findings and show that DDK inhibitor–induced mitotic entry delay is dependent upon WEE1 kinase. Specifically, WEE1 phosphorylates CDK1 and prevents mitotic entry upon DDK inhibition due to the presence of underreplicated DNA, potentially limiting the cytotoxic effects of DDK inhibition. To overcome this, we combined the inhibition of DDK with the inhibition of WEE1 and found that this results in elevated levels of premature mitotic entry, mitotic catastrophe, and apoptosis. Importantly, we have found that DDK and WEE1 inhibitors display a synergistic relationship with regards to reducing cell viability of Ewing sarcoma cells. Interestingly, the cytotoxic nature of this combination can be suppressed by the inhibition of CDK1 or microtubule polymerization, indicating that mitotic progression is required to elicit the cytotoxic effects. This is the first study to display the potential of utilizing the combined inhibition of DDK and WEE1 for the treatment of cancer. We believe this will offer a potential therapeutic strategy for the treatment of Ewing sarcoma as well as other tumor types that display sensitivity to DDK inhibitors.

Significance:

Ewing sarcoma is an aggressive pediatric cancer for which chemotherapy is very intense and often results in acute toxicities. Here, we have found that the combined inhibition of CDC7 kinase (DDK) and WEE1 kinase forces high levels of mitotic errors and synergistic cell death, specifically in Ewing sarcoma cells. This combination has the potential to provide a highly efficacious and minimally toxic treatment strategy for patients with Ewing sarcoma.
Efficacy and Safety of Multiple Dupilumab Dose Regimens in Patients with Moderate-To-Severe Atopic Dermatitis: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials
Authors: Shih Ya-Chu , Yeh Marvin Chia-Han , Yang Fu-An , Chen Hung-Chou
Published: June 2022

Background: Dupilumab ameliorates the signs and symptoms of atopic dermatitis (AD) and improves the patient’s quality of life. Multiple-dose regimens of dupilumab have been applied by clinicians, but the efficacy of some regimens remains unclear. Objectives: The aim of the study was to systematically evaluate the efficacy and safety of multiple dupilumab dose regimens in patients with moderate-to-severe AD in terms of comprehensive outcomes. Methods: We searched electronic databases and subjected the selected studies to risk-of-bias assessment and network meta-analysis (NMA). Efficacy and safety outcomes were compared using a random-effects NMA to estimate pooled relative risk ratio (RR) of direct and indirect comparisons among multiple dupilumab dose regimens. The Eczema Area Severity Index, Investigator’s Global Assessment, and pruritus numerical rating scale were analyzed to assess the efficacy, while adverse events (AEs) and serious adverse events to represent the safety. Results: Eight randomized controlled trials involving 3,679 patients were identified. Most patients received therapy for 16 weeks. Multiple dupilumab dose regimens, including 300 mg weekly (QW), 300 mg every 2 weeks (Q2W), 200 mg Q2W, 300 mg monthly (QM), 300 mg every 2 months (Q2M), and 100 mg QM were analyzed. All regimens, except 100 mg QM, had significantly better efficacy than placebo. 300 mg QW and 300 mg Q2W appeared to have similar efficacy. Notably, both 300 mg QW and 300 mg Q2W had no significantly better efficacy than 300 mg QM. As for 300 mg Q2M, significantly reduced efficacy was noted in only one efficacy outcome when compared to 300 mg QW and 300 mg Q2W. In terms of safety outcomes, AEs occurring with any of the regimens were comparable with the placebo. No significant inconsistency was noted within the network in all efficacy outcomes. Conclusions: Our NMA indicated that the administration of the following dupilumab regimens was effective for patients with moderate-to-severe AD: 300 mg QW, 300 mg Q2W, 200 mg Q2W, 300 mg QM, and 300 mg Q2M. Our data can improve the understanding of the relative efficacy and safety of multiple dupilumab dose regimens, which will help in shared decision-making between clinicians and patients.
Three Types of Subepithelial Lesion-Like Gastric Cancer Including a New Entity of Gastric Adenocarcinoma
Authors: Yamamoto Kazuki , Ikeya Takashi , Kanomata Naoki , Deshpande Gautam Anil , Takagi Koichi , Omata Fumio
Published: June 2022

Gastric subepithelial lesions (SEL) are usually found incidentally during esophagogastroduodenoscopy. Most gastric SELs are benign lesions, such as leiomyoma and pancreatic rests. However, neoplastic lesions including neuroendocrine tumors, gastrointestinal stromal tumors, and certain types of gastric adenocarcinoma (GA), such as the recently WHO-classified fundic gland type adenocarcinoma, may be found. The lack of simple and established diagnostic methods for SEL remains a clinical challenge. Standard biopsy is suboptimal for diagnosis due to the subepithelial location of lesions and is therefore often omitted. Furthermore, guideline-based algorithmic approaches for diagnosing SEL also differ between Japan and the USA. In this case series, we describe three cases of gastric SEL that were subsequently diagnosed as GA. Case 1 was a fundic gland type (chief cell predominant type) adenocarcinoma; Case 2 was a poorly differentiated GA; Case 3 was an advanced GA, found after 4 serial years of endoscopic follow-up for SEL. While standard biopsy led to successful diagnosis in the first 2 cases, no standard biopsy was performed during surveillance in Case 3, making its diagnostic effectiveness unclear. The third case highlights the importance of longitudinal observation for endoscopic mucosal alterations that may suggest certain types of GA. Clinicians should be aware that standard biopsy may play an important role in the evaluation of malignant gastric SEL-like lesions. It is crucial to remain vigilant for surface changes in SEL and not to summarily omit standard biopsy.
Comparação do ganho de flexibilidade isquiotibial com diferentes técnicas de alongamento passivo
Authors: Bonvicine Cristiane , Gonçalves Claus , Batigália Fernando
Published: June 2022

Embora vários estudos tenham investigado os efeitos dos exercícios na amplitude de movimento e rigidez articular, a duração ideal do alongamento ainda não foi determinada. Este estudo objetivou comparar os efeitos de duas diferentes técnicas de alongamento muscular isquiotibial repetitivo passivo quanto ao ganho de amplitude de movimento, durante quatro semanas. Foram estudadas 30 mulheres, voluntárias, de mesma faixa etária, divididas em dois grupos de quinze. Foi realizada a goniometria da flexão de quadril de ambos os membros inferiores das 30 voluntárias. O grupo estudado recebeu uma sessão de alongamento sustentado por 60 segundos no membro inferior direito e 2 sessões de alongamento de 20 segundos, com intervalo de 10 segundos, no membro inferior esquerdo. As outras 15 participantes constituíram o grupo controle e não receberam nenhuma intervenção. A comparação do ganho de alongamento entre os grupos foi realizada pelo teste t de Student (amostras de distribuição normal), teste t para amostras variáveis (amostras de distribuição não normal), e teste t pareado (para a comparação entre as duas sessões de alongamento). O ganho de alongamento no membro inferior direito no grupo tratado foi significativo(p<0.001), assim como o ganho de alongamento no membro inferior esquerdo (p<0.001). A variação da amplitude de movimento no grupo controle não foi significante (p=0,80). O ganho de amplitude de movimento foi maior no membro inferior direito (p=0,001). O ganho de amplitude de movimento para a musculatura isquiotibial mostrou ser maior em sessões de alongamento passivo de uma série de 60 segundos cada.
Avaliação dos sintomas de disfunção miccional em crianças e adolescentes com paralisia cerebral
Authors: Amaral Cássia Maria Carvalho Abrantes do , Carvalhaes João Tomás de Abreu
Published: June 2022

Avaliar as disfunções do trato urinário inferior (DTUI) em pacientes com paralisia cerebral (PC) e sua relação com variáveis como: diagnóstico neurológico, idade, sexo, realização ou não de pré-natal durante o período gestacional, peso ao nascimento, deambulação, fala, cognitivo, constipação intestinal e história de infecção do trato urinário (ITU), além de verificar, entre os casos estudados, a presença de bexiga neurogênica. Métodos: Estudo transversal que avaliou 100 pacientes com idade entre 2 e 18 anos completos com diagnóstico de PC que compareceram em consulta pediátrica no ambulatório de pediatria da Associação de Assistência à Criança Deficiente (AACD), sem deficiência mental (DM) grave através de avaliação psicológica de QI, entrevista pediátrica e estudo urodinâmico. Resultados: Após a avaliação de 100 casos de PC entre crianças e adolescentes de 2 a 18 anos, foram verificados 30 casos de pacientes com sintomas urinários, 11 destes com quadros urológicos de bexiga neurogênica. Entre as variáveis analisadas, apenas a média de idade (9,35 anos) apresentou relação estatisticamente significativa com a presença de sintomas urinários. Conclusão: As crianças e adolescentes com PC apresentaram sintomas de disfunções do trato urinário independente das variáveis analisadas, exceto pela idade, o que pode estar relacionado talvez à menor gravidade de seus quadros de DM e deficiência motora. Entre os pacientes com sintomas urinários, 11 apresentaram estudos urodinâmicos compatíveis com bexiga neurogênica (36,67%). O diagnóstico dos sintomas de disfunção do trato urinário precoce tem como objetivo evitar possíveis alterações do trato urinário superior, além de significar um tratamento preventivo para estes pacientes, proporcionando uma melhora de qualidade de vida e ajudando no processo de sua reabilitação e incorporação à sociedade.
Influência da transferência reto-femoral na excursão dos joelhos em pacientes com paralisia cerebral
Authors: Binha Anny Michelly Paquier , Cristante Adriana Rosa Lovisotto , Alonso Gláucia Somensi de Oliveira , Morais Filho Mauro César , Juliano Yara
Published: June 2022

A marcha com o joelho rígido é um padrão comum na paralisia cerebral e a etiologia, em muitos casos, é a espasticidade do músculo reto-femoral. A transferência deste músculo para flexor de joelho tem sido usada como tratamento, porém com resultados variados. Para avaliar a efetividade deste procedimento, vinte e oito pacientes com paralisia cerebral tipo diparesia espástica, submetidos à transferência do reto-femoral, foram estudados retrospectivamente. No subgrupo A (n=16), os pacientes não usavam órteses ou auxiliares para marcha e enquanto que no subgrupo B (n=12) sim. Foi considerado como critério de inclusão a realização da análise computadorizada da marcha antes e após cirurgia. O objetivo foi avaliar o efeito do tratamento no arco de movimento dos joelhos (cinemática) e na qualidade de vida dos pacientes (questionário). Resultados mostraram aumento do arco de movimento dos joelhos para os dois subgrupos (p=0,006 para o A e p=0,045 para B). A avaliação subjetiva (questionário) demonstrou alto nível de satisfação após tratamento apesar dos familiares responderem que quase não houve mudanças nas atividades de vida diária. Os resultados sugerem ser necessário uma investigação adicional para identificar outros fatores que poderiam alterar os resultados e que, um instrumento mais objetivo, como o GMFM é uma opção melhor para avaliação funcional.
Avaliação da neuropatia periférica: correlação entre a sensibilidade cutânea dos pés, achados clínicos e eletroneuromiográficos
Authors: Souza Ary , Nery Caio Augusto de Souza , Marciano Lúcia Helena Soares Camargo , Garbino José Antonio
Published: June 2022

Objetivo: Avaliar a eficácia dos monofilamentos de Semmes-Weinstein no diagnóstico e prognóstico do pé com neuropatia diabética. Método: Estudo prospectivo em 35 pacientes diabéticos tipo II. Os pacientes foram submetidos a um protocolo contendo anamnese, levantamento das queixas, exames clínicos, estudo neurofisiológico e pesquisa da sensibilidade cutânea nos pés. Resultado: Pôde-se constatar bom grau de concordância entre os monofilamentos de Semmes-Weinstein e o estudo neurofisiológico. Os monofilamentos de Semmes-Weinstein se revelaram sensíveis para detectar pacientes com algum tipo de alteração. Discussão: constatou-se bom grau de coincidência entre os monofilamentos de Semmes-Weinstein e o estudo neurofisiológico expresso pelo coeficiente de correlação de Spearman (r= 0,677). Os monofilamentos de Semmes-Weinstein demonstraram ser eficazes na detecção de alterações da sensibilidade cutânea, observando-se que 91% dos pacientes apresentaram variações entre os graus 2 e 5. O estudo neurofisiológico detectou 69% dos pacientes na faixa de 2 a 5 graus. A maior diferença entre os dois métodos ficou evidenciada nos pacientes sem comprometimento (grau 1), demonstrando uma sensibilidade mais elevada dos monofilamentos de Semmes-Weinstein. O estudo também mostrou uma boa correlação entre o comprometimento clínico dos pacientes com os déficits neurológicos medidos pelos monofilamentos de Semmes-Weinstein. Conclusão: os monofilamentos de Semmes-Weinstein são confiáveis para diagnosticar a neuropatia diabética dos pés. Há correlação entre os achados neurofisiológicos e os critérios clínicos obtidos com os monofilamentos. Os monofilamentos de Semmes-Weinstein ajudam na avaliação do prognóstico e evolução do pé diabético e podem ser utilizados com segurança na avaliação dos pés com neuropatia periférica.
Avaliação objetiva da síndrome dolorosa miofascial: uso da termografia antes e após tratamento associando mesoterapia a bloqueio anestésico
Authors: Balbinot Luciane Fachin , Vieira Luiz Rosa
Published: June 2022

A Síndrome miofascial é um diagnóstico comum em pacientes com dor segmentar. As queixas costumam ser inespecíficas; o uso da técnica de Fischer associando algometria de pressão e técnicas especiais de palpação auxiliam a identificar os pontos gatilhos ativos. A mesoterapia (intradermoterapia) mostra-se muitas vezes mais eficaz quando associada às técnicas de bloqueio paraespinal e bloqueio de pontos gatilhos com lidocaína. O resultado deste tratamento pode ser documentado através da termografia, além dos meios clínicos já citados. O padrão de cores (vermelho a verde, no caso da imagem colorida ou tons de cinza na imagem em preto e branco) indica gradiente de temperatura. Neste estudo, descrevemos o caso clinico de uma paciente feminina, de 54 anos de idade, com queixa de dor severa em região cervical, referida ao membro superior direito. A mesma foi tratada com mesoterapia associada a bloqueio paraespinal e bloqueio de pontos-gatilho ativos e o resultado deste tratamento foi avaliado clinicamente e pela termografia 25 minutos após e 03 dias após o tratamento. Os autores concluíram que a termografia é um método promissor na avaliação da dor miofascial. Mais estudos são necessários para usar a termografia como método auxiliar na triagem de casos de LER/DORT, visto que, em nossa experiência, é freqüente a associação desta síndrome, como fator agravante.
Aplicação da versão brasileira do questionário de dor Mcgill em idosos com dor crônica
Authors: Santos Clarissa Cardoso dos , Pereira Leani Souza Máximo , Resende Marcos Antônio de , Magno Frederico , Aguiar Vanessa
Published: June 2022

A dor crônica é uma experiência multidimensional que envolve aspectos sensório-perceptual, afetivo-motivacional e cognitivo-avaliativo que se interagem e contribuem para a resposta dolorosa final. As alterações características do processo do envelhecimento em cada um desses aspectos podem interferir na experiência da dor, dificultando a sua avaliação adequada. O uso de uma escala multidimensional como o Questionário de dor McGill (MPQ) possibilita uma avaliação mais adequada desse sintoma. Os objetivos desse estudo foram verificar a confiabilidade intra e inter examinadores da aplicação do Br-MPQ em idosos com dor crônica em decorrência de doenças ortopédicas e neurológicas.Participaram desse estudo 19 idosos com doenças ortopédicas (71,21 ± 7,51 anos) e 19 idosos com doenças neurológicas (69,79 ± 5,30 anos) apresentando o diagnóstico de dor crônica, encaminhados pelo serviço médico, sem alterações cognitivas. A confiabilidade geral intra e interexaminadores nos idosos com doenças ortopédicas foram 0,86 e 0,89, respectivamente, e para idosos com doenças neurológicas de 0,71 e 0,68, respectivamente (Spearman, p<0,05). Os resultados mostraram que o Br-MPQ foi de fácil aplicação (8,54 ± 2,35 minutos) nessa amostra. O presente estudo demonstrou que o Br-MPQ pode ser mais adequado para avaliar a dor crônica em idosos, uma vez que a percepção desse sintoma está mais relacionada aos aspectos sensoriais, afetivos e cognitivo-avaliativos e não somente à intensidade.
Benefícios do treinamento com pesos para aptidão física de idosos
Authors: Dias Raphael Mendes Ritti , Gurjão André Luiz Demantova , Marucci Maria de Fátima Nunes
Published: June 2022

O objetivo desta revisão é elucidar os benefícios do treinamento com pesos (TP) sobre quatro componentes da aptidão física (AF) fundamentais para a qualidade de vida de idosos: força, flexibilidade, equilíbrio e resistência aeróbia. Foi realizada pesquisa bibliográfica nas bases de dados PUBMED e LILACS. Foram selecionados estudos que incluíam no título os descritores: strength training, resistance training, strength, balance, flexibility, power, aerobic, older e elderly. Modificações na força muscular são observadas após poucas semanas de TP. Essa melhoria pode auxiliar não só na independência dos idosos, mas também na diminuição da incidência de quedas. Além disso, a prática sistematizada do TP promove melhoria na flexibilidade e na resistência aeróbia de idosos. As modificações no equilíbrio, após programas de TP, ainda não estão bem esclarecidas na literatura. Desta forma, o TP consiste numa importante ferramenta para a melhoria da AF de idosos, haja vista que promove adaptações na força muscular, flexibilidade e na resistência aeróbia.
Avaliação da sensibilidade de membros superiores em pacientes com linfedema pós mastectomia radical
Authors: Greve Patrícia , Dalaruvera Karin Luise , Benvenuto Fernando Barbosa , Guedes Neto Henrique Jorge
Published: June 2022

O objetivo deste trabalho foi avaliar a sensibilidade de membros superiores com linfedema pós- mastectomia radical. Foram avaliadas nove pacientes, com média de idade de 60,7 anos, para verificar se ocorre diferença de sensibilidade entre o membro com linfedema e o membro sem linfedema. Para o teste de sensibilidade foram utilizados 6 monofilamentos de Semmens-Weinstes (modelo de bolso) “sensi kit”. As áreas testadas foram aquelas correspondentes aos dermátomos ligados à distribuição dos nervos ulnar, mediano e radial. Como resultados tivemos que o tempo decorrido desde a cirurgia foi em média de 8,9 anos, e o aparecimento do linfedema ocorreu em média 5,5 anos após a cirurgia. Utilizou-se a estatística não-paramétrica, empregando-se o Teste de Fisher para pequenas amostras, das freqüências encontradas. Para cada lado testado evidenciou que a freqüência de pacientes que apresentaram sensibilidade no lado acometido foi significativamente menor (0,0045; p>0,005) do que a observada no lado controle, quando testado o Ponto 1, cor verde; não houve diferenças estatisticamente importantes entre os lados avaliados nos demais pontos e cores testados; com relação ao grau de incapacidade, conforme o Ministério da Saúde, não houve qualquer diferença significativa entre os lados acometido e controle em qualquer dos sete pontos testados.
Computational evaluation of the footprint: reference values of the plantar arch index in a sample of the Brazilian population
Authors: Ramos Margot Guarieiro , Pereira Fabricio Ramos Silvestre , Nucci Anamarli
Published: June 2022

The presence of the medial longitudinal arch (MLA) is characteristic of the human feet and has been used for the classification of the normal, cavus and flat foot. The literature provides information on several methods and different techniques for the measurement of the MLA, each of them presenting advantages and disadvantages. We chose the footprint method and the measurement of arch index (AI) as an indirect evaluation of the MLA height. This method was chosen due to its simple, cost-effective and noninvasive characteristics. We followed the basic principles of the IA measurement proposed by Cavanagh & Rodgers, but modified it, by introducing the footprint scanning and AI calculation using a software program created by one of the authors. A total of 100 footprints were analyzed from 25 male and 25 female healthy, nonobese subjects, with a mean age of 34.7 years, ranging from 10 to 59 years. The AI reference values obtained from a sample of the Brazilian population were 0.21< IA < 0.25. There was no significant statistical difference between the values obtained from the Brazilian and American samples.
Instruments of functional assessment of elderly submitted to orthopedic surgery: an integrative review of literature
Authors: Alvarenga Márcia Regina Martins , Mendoza Isabel Yovana Quispe , Faro Ana Cristina Mancussi e
Published: June 2022

Illnesses from muscles and skeleton, constitute the cause of functional damage of elderly. Nevertheless they are not inevitable consequences of age and they should be approached as specific illnesses rather then being regarded as result of aging. All aspects of health must be accounted for the measurement of the elderly health (Full Geriatric Assessment). Objective: To review the scientific publication dealing with the functional condition of elderly after subjected to orthopedic surgery. Material and Method: Bibliographic research on articles as per listing in the following databases www.bireme.br, www.ncbi.nlm.nih.gov/pubmed, www.scopus.com and www.embase.com covering a period from 1996 to 2006. It has been adopted the terminology as per Science of Health (DeCs/Birene) and at Medical Subject Headings (MeSH/PubMed) that identified the key-words: elderly, daily activity, orthopedic surgery or orthopedic procedures, post-surgery and rehabilitation. The search was carried out on April 2006 and the inclusion criterion was that the test subjects should be older than 60 and subjected to any orthopedic surgery procedure. The references meeting this criterion were listed and analyzed in EpiInfo version 3.3.2. The variables were: title, year and country of publication, professional categories of the authors, country of origin of the study, objective of the research, number of assessment tools, types of assessment tools, site of the surgery, full report available on line. Results: 44 abstracts have been selected among of which 29 were available as full reports. The Journal of the American Geriatric Society was the one that has published the largest number of articles dealing with this issue and the US was the country that has issued the greatest number of publication. 75% of the articles fitted within medical category, 79.3% of the studies are descriptive, 69% of the surgeries were on the hips and 27.6% of the searches employed only one assessment tool. Among the dimensions that have been evaluated 43.6% dealt with functional status while 30.8% were about mental status. Final Notes: The functional dimension was the most investigated while the social dimension was not contemplated. Although the number of publication is increasing in the last years, it’s necessary that health service starts to incorporate the new paradigm of functional evaluation of the elderly health.
Correlation between the ambulation profile and gait velocity in a group of hemiplegic patients treated at a rehabilitation center
Authors: Franzoi Ana Cristina , Kagohara Nelson Shigueru
Published: June 2022

The gait of hemiplegic patients is characterized by decreased velocity and asymmetry, which brings limitations to the activities of daily living and restrictions in the individual’s social integration. The aim of this study was to describe the functional ambulation profile in this group of patients and correlate it with gait velocity. Methods: 87 patients were evaluated using the Modified Functional Gait Classification (MFGC), gait velocity at 10 meters, with the identification of the need for help and use of public transportation. Statistical analysis: descriptive analysis; comparison between groups and correlation tests (p≤0.05). Results: 49 male individuals, with a mean age of 54 yrs, mean injury time of 33 months. Three patients performed therapeutic gait, 10 at-home gait, 29 restricted community gait, 43 community gait and 2 presented normal gait. Regarding gait assistance: 38 patients needed help or supervision from others, 45 used public transportation, 59 did not need gait support. Gait velocity was different among the groups divided by the gait functional type, need for others’ help and use of public transportation, correlated with age, MFGC, help from others and use of public transportation. Conclusion: 85% of the sample performed community gait, but only 55% did it independently. There was a correlation between gait velocity and the functional types of gait evaluated, with gait velocity thresholds being established for the different groups.
Clinical assessment of the thigh and leg with the use of anatomic repairs and correlation with the radiographic evaluation in children between 7 and 12 years of age in the city of Londrina, state of Parana, Brazil
Authors: Pazin Adriana Prueter , Dal Molin Ellen Mara Canesin , Santana Paulo José , Dal Molin Eden , Dal Molin Danilo Canesin , Guarniero Roberto
Published: June 2022

Limb length discrepancies are common in the general population, but they only cause functional problems when they are over 1.5 cm. Objective: To make a correlation between clinical and radiological assessments of children´s thigh and leg lengths between 7-12 yrs, through slit scanogram measurement. Method: Prospective study of limb length in 300 children between 7-12 yrs, of both sexes, through clinical measurement using a measuring tape and radiographic assessment using the supine slit scanogram technique. The correlation between the assessments was made by simple linear regression. Results and discussion: The statistical analysis showed that there are differences between the clinical and the radiographic assessments (p<0.05). The simple linear regression was used to verify the correlation and to define the correlation equation. Using this equation, it is possible to define the radiographic values based on the clinical assessment. Conclusion: The clinical and radiographic assessments are statistically different; however, there is a correlation between them, which allows the use of an equation to predict the radiographic values based on the clinical assessment.