bluuebunny/crossref_metadata_2025 huggingface dataset:
Linear dynamic system phase coordinates vector:sensitivity functions definition according to the integro-power series from the matrix of parameter variations
Authors: Tushev O.N. , Belyaev A.V.
Published: July 2022

The paper introduces a method for calculating sensitivity functions of the first and second orders of phase coordinates that do not require the integration of cumbersome chain-related systems of differential equations. The general and particular solutions of the vector differential equation of motion, written in the Cauchy form, are expressed in terms of the fundamental matrix. With the help of formal transformations, the vector of phase coordinates is represented as a convergent integro-power series with respect to the matrix that determines the variations of the elements of the matrix of system equation coefficients. In this work, the system is called the variation matrix. Then the relations obtained are transformed by special operations to an explicit form with respect to these variations up to and including the quadratic approximation. Within the framework of the matrix apparatus, there are similar expansions in terms of variations of the external influence and initial conditions. To exclude numerous "parasitic" operations of multiplication by zero in calculations, it is proposed to use special operations of matrix algebra. The original and inverse fundamental matrices are treated as multiplicative integrals, which ensures their simple calculation in time using recurrent formulas. The resulting apparatus is built entirely on matrix operations, which ensures simple machine implementation and versatility.
Characterization of demethylating DNA glycosylase ROS1 from Nicotiana tabacum L.
Authors: Petrova D. V. , Permyakova N. V. , Grin I. R. , Zharkov D. O.
Published: July 2022

One of the main mechanisms of epigenetic regulation in higher eukaryotes is based on the methylation of cytosine at the C5 position with the formation of 5-methylcytosine (mC), which is further recognized by regulatory proteins. In mammals, methylation mainly occurs in CG dinucleotides, while in plants it targets CG, CHG, and CHH sequences (H is any base but G). Correct maintenance of the DNA methylation status is based on the balance of methylation, passive demethylation, and active demethylation. While in mammals active demethylation is based on targeted regulated damage to mC in DNA followed by the action of repair enzymes, demethylation in plants is performed by specialized DNA glycosylases that hydrolyze the N-glycosidic bond of mC nucleotides. The genome of the model plant Arabidopsis thaliana encodes four paralogous proteins, two of which, DEMETER (DME) and REPRESSOR OF SILENCING 1 (ROS1), possess 5-methylcytosine-DNA glycosylase activity and are necessary for the regulation of development, response to infections and abiotic stress and silencing of transgenes and mobile elements. Homologues of DME and ROS1 are present in all plant groups; however, outside A. thaliana, they are poorly studied. Here we report the properties of a recombinant fragment of the ROS1 protein from Nicotiana tabacum (NtROS1), which contains all main structural domains required for catalytic activity. Using homologous modeling, we have constructed a structural model of NtROS1, which revealed folding characteristic of DNA glycosylases of the helix– hairpin–helix structural superfamily. The recombinant NtROS1 protein was able to remove mC bases from DNA, and the enzyme activity was barely affected by the methylation status of CG dinucleotides in the opposite strand. The enzyme removed 5-hydroxymethylcytosine (hmC) from DNA with a lower efficiency, showing minimal activity in the presence of mC in the opposite strand. Expression of the NtROS1 gene in cultured human cells resulted in a global decrease in the level of genomic DNA methylation. In general, it can be said that the NtROS1 protein and other homologues of DME and ROS1 represent a promising scaffold for engineering enzymes to analyze the status of epigenetic methylation and to control gene activity.
Taxonomic structure of bacterial communities in sourdoughs of spontaneous fermentation
Authors: Khlestkin V. K. , Lockachuk M. N. , Savkina O. A. , Kuznetsova L. I. , Pavlovskaya E. N. , Parakhina O. I.
Published: July 2022

The article is devoted to the study of the microbiome of spontaneously fermented sourdoughs. The aim of the work was to study the influence of the technological parameters of sourdough propagations on the taxonomic structure of the microbiome of spontaneously fermented sourdoughs. Two spontaneously fermented sourdoughs were studied: dense rye sourdough and liquid rye sourdough, both prepared using the same batch of peeled rye flour. To study the taxonomic structure of the sourdough microbiome in dynamics, the method of high-throughput sequencing of 16S rRNA gene fragments of microorganisms was used. It was shown that the technological parameters of sourdough (humidity, temperature) do not affect the taxonomic composition of the microbiome of dense rye or liquid rye sourdough at the phylum/class/genus level. It was found that during the first three days of propagations, bacteria from the phyla Proteobacteria and Firmicutes dominated in the microbial community. In the phylum Proteobacteria, microorganisms from the order Enterobacterales took a large share, which persisted for three days of backslopping. The phylum Firmicutes was represented by lactic acid bacteria of the genera Weissella, Lactobacillus, Leuconostoc, Pediococcus, Lactococcus. It was established by classical microbiological methods that after a day of fermentation, the number of lactic acid bacteria cells was significantly higher in liquid rye sourdough compared to dense one. However, with further propagation of sourdoughs, the number of cells was comparable, while significant changes occurred at the level of genera and species. It was shown that as the relative number of lactic acid bacteria of the genus Lactobacillus increased, a gradual displacement of the coccal forms of Lactococcus, Leuconostoc, Weissella, Pediococcus happened. With further propagation of sourdough after 10 days, the position of the dominant groups of bacteria was occupied by representatives of the phylum Firmicutes, lactic acid bacteria of the genus Lactobacillus. The influence of the mode and parameters of the sourdough on the species composition of lactobacilli, which demonstrated a low bacterial diversity, is shown. In the first three days of propagations, lactobacilli L. curvatus, L. brevis, and Lactiplantibacillus sp. dominated in both sourdoughs. After a month of backslopping, Fructilactobacillus sanfranciscensis and Companilactobacillus sp. dominated in dense rye sourdough, and L. pontis dominated in liquid rye sourdough.
Wychowanie–tożsamość–ciało–płeć. Wprowadzenie w problematykę
Authors: Gajek Katarzyna , Desperak Izabela
Published: July 2022

Tekst prezentuje zawartość czternastego numeru czasopisma „Nauki o Wychowaniu. Studia Interdyscyplinarne” będącego przestrzenią dla interdyscyplinarnej dyskusji nad związkami procesów wychowania, kształcenia i socjalizacji z kategoriami tożsamości, ciała oraz płci.
Between Grandma and Granddaughter – The Process of Becoming a Black Woman in a Racist Society. Analysis of Intergenerational Transmission on the Example of bell hooks’ autobiography Bone Black: Memories of Girlhood
Authors: Ostaszewska Aneta
Published: July 2022

The aim of the essay is to discuss an intergenerational transmission of family history and its impact on the process of becoming a Black woman in a racist society. The example chosen for analysis is the autobiography of bell hooks, Bone Black: Memories of Girlhood (1996), which is a story about girlhood. (B)ell hooks is a pen name of Gloria Jean Watkins, an African-American scholar and writer whose childhood and adolescence were during the period of racial segregation and desegregation in the 1960s of the twentieth century. (B)ell hooks writes Bone Black to reflect on being a Black girl growing up in racially segregated American society in the 60s of the twentieth century. She shows the historical and political contexts of her growing up, however, it is the local community and intergenerational family ties that she places at the center of her process of becoming the woman: bell hooks. Relationships with women, particularly a relationship between grandmother and granddaughter are of great significance in this process. The essay begins with a brief summary of the biography of bell hooks and a description of Bone Black, with particular emphasis put on the author’s interand intragenerational relationships with women. Next, I will move on to discuss the intergenerational transmissions of family history and their impact on the process of becoming a woman. For this purpose, I will refer to the life story concept introduced by Daniel Bertaux (2016), and the notion of subjective resources created by Catherine Delcroix (1999, 2014), in order to discuss the importance of intergenerational transmission of life stories in the process of becoming the woman knowns as “bell hooks.”
Effect of Ocimum basilicum in Cobb 500 chickens on the productive and bacterial parameters
Authors: Sánchez Quinche Angel Roberto , Caraguay Morocho Miguel Ángel , Caiminagua Romero Deivis Fabián , Castillo Del Hierro Brando Gabriel , Vargas Gonzales Oliverio Napoleón
Published: July 2022

The research was developed at the Santa Inés Farm, of the Faculty of Agricultural Sciences of the Universidad Técnica de Machala, the objective was to evaluate the effect of the infusion of Ocimum basilicum in Cobb 500 chickens on the productive parameters and bacterial control. For the experiment, a Completely Random Design was applied to evaluate five treatments each with four experimental units of 10 chickens (200 birds). The treatments were: T1, T2, T3, and T4, to which 2 ml of infusion of O. basilicum was added at 10%, 20%, 30% and 40% respectively for each liter of drinking water and T5 normal water. For the welfare of the birds, management was used for open buildings, administering a balanced feed free of Antibiotic Growth Promoters. The variables evaluated were: live weight of the bird, consumption of feed and accumulated water, feed conversion, mortality, total bacterial microbiota and colimetry. For data analysis, the statistical program Statgraphics Centurión XV.I.® was used, subjecting the variables to an ANOVA, prior assumptions of normality and homogeneity, and the Kruskal-Wallis test for those that did not present a normal distribution. To establish the difference between the means, the Bonferroni multiple comparison procedure was used with a 95.0% confidence level. The results conclude that there is no effect on the parameters evaluated, it does not present a health risk and that due to its biopharmaceutical properties it could be used as an alternative to synthetic antibiotics.
Ideología y realidad
Authors: Calderón González Jacinto H.
Published: July 2022

Resumen. 

El presente artículo quiere dar cuenta del conflicto que presentan las ideologías cuando toman como referencia la realidad y la convierten en algo vacío. Para ello se examinan algunas de las tácticas de las ideologías: la producción de discursos, la idea de la propaganda, la conciencia de los ciudadanos, la identificación del contrario y los problemas derivados de la relación abstracto-concreto. De este modo, se pretende hacer que incluso hoy día las ideologías tienen mucho peso y funcionan como sustitutivas de la realidad.
Spettralità: tra la vita e a morte
Authors: Dadà Silvia
Published: July 2022

The aim of this article is to analyze the concept of spectrality in Jacques Derrida's thought. To do this, I will start from the terminological aspect, in order to distinguish this notion from that of "spirit". Then, I will try to compare the derridean view with the idea of spirit in Hegel and Heidegger. At this point, I will show how the spectrum is a useful deconstructive category, because it allows to think in a new way the dichotomous pairs typical of metaphysical thought: presence/absence, life/death, soul/body, personal/impersonal. Finally, I will show the ethical scope of this concept, describing the relationship between it and the idea of justice.
Rodrigo, J. (2019). La caída. Viejo San Juan: Ediciones Laberinto
Authors: Padilla-Teruel Reynaldo
Published: July 2022

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THE VFW 614 FOKKER PROJECT AND THE ROMANIAN AERONAUTICAL INDUSTRY IN THE 1970s
Authors:   Consiliul Național de Studierea a Arhivelor Securității, București, Taranu Liviu
Published: July 2022

n a ‘70s meeting of the Socialist Republic of Romania’s (RSR) Defense Council, Nicolae Ceausescu decided to have Romanians build a short-courier aircraft capable of ensuring passenger traffic, domestic and foreign, over short distances. Based on these indications, a contact was designed and several offers were obtained for the joint construction of such an aircraft: the British company "BAC" for an aircraft to be designed and developed at the request of the Romanian side, the British company "Hawker Siddeley, for the HS 748 aircraft, already manufactured in a military version, subject to obtaining the approval of the English government, the French company “SNIAS”, for the Nord-262-Fragatte aircraft which did not meet the Romanian requirements and, finally, from the West German company VFW Fokker, initially for the F. 98 aircraft, manufactured in the Netherlands, and then for the VFW 614 aircraft, both of which were introduced in Bucharest in September 1972 and May 1973, respectively. In the following study, the evolution of the negotiations with the West German side and the causes of the final failure in taking over the VFW-614 model for Romanian domestic production are presented and analyzed
Method for clarification of Pareto set on the basis of consideration for stochasticity of criterial functions
Authors:   Ural state university of railway transport (USURT), Koshheev Anton Alexeevich , Timukhina Elena Nikolaevna ,   Ural state university of railway transport (USURT), Kashheeva Natalya Vyacheslavovna ,   Ural state university of railway transport (USURT), Okulov Nikolay Evgenyevich ,   Ural state university of railway transport (USURT), Yakushev Nikolay Vasilyevich ,   Ural state university of railway transport (USURT)
Published: July 2022

Selection of rational structural and technological parameters of railway transport objects is an important task in the sphere of operations control. The analysis of theory and practice showed that the selection of structural and technological parameters is carried out with insufficient accuracy and can lead to irrational decisions. In order to increase quality of decisions aimed at development of infrastructure and technology of railway stations the authors propose to use a bicriterial approach. For the decrease of negative subsequences and a risk of making irrational decisions the authors suggest a method for clarification of a Pareto set on the basis of consideration for stochasticity of criterial functions. The method includes the following steps: calculation of confidence interval for assessment of mathematical expectation, correlation analysis, construction of scattering ellipses and single-factor variance analysis. In order to confirm the efficiency of the suggested method the paper presents results of selection of the most rational variant for the increase of estimated capacity of a freight railway station.
Improving the efficiency of the snow removal operating process through the implementation of efforts of cost structure optimization
Authors:   Siberian Transport University (STU), Abramov A. D. , Semenov M. A. ,   Siberian Transport University (STU)
Published: July 2022

The reasons for the inefficient operation of snow removal equipment are considered and the sources for operating process optimization are specified. The problematic issue of the operating process optimization of the snow removal equipment is a multifaceted task. The solution to this issue requires an assessment of expediency of using all kinds of snow removal equipment, depending on a snowfall level, and an analysis of the operating process structure to reduce the share of idle mode and the use of the automated monitoring of operating process in order to increase the efficiency of using snow-grooming machines such as SM and PSS. In order to achieve that, using mathematical modeling, the parameters are determined at which the operating process of snow removal equipment is optimal. For the costs optimization of the snow removal equipment handling, the snow removal process is modeled. This model includes elements of the structure of workshift, machine performance and weather conditions. This affects the length of the railway tracks under snow-removal procedure to one degree or another as an effective feature; unless all factors are taken into consideration simultaneously, it is possible to properly assess the efficiency of a snow-grooming machine through the length of the railway track under snow-removal procedure. The actual impact of each of the factor variables is determined by means of the multiple correlation. The article also highlights the necessity to take into account the core results of production and economic activity of employees and their interests. By changing the approach to the bonus-award system, calculating productivity and carrying out maintenance and repair procedures, it is possible to optimize the cost structure.
Future social work professionals’ ideas about social entrepreneurship
Authors:   Samara national research university named after academician S. P. Koroliov, Vandysheva Lyudmila V.
Published: July 2022

The relevance of professional training of future social work specialists for social entrepreneurship is justified by the modernization of the system of social protection of the population. Social entrepreneurship is like an innovative social technology. Social work professionals – social entrepreneurs can act as social innovators. In addition, the relevance is justified by the formation of a model of a socio-entrepreneurial university. Modern youth has an innovative potential and at the same time it is not ready for social entrepreneurship; theory and considerable experience have been gained in the methodology of professional training, but there is no built-in system for training future social entrepreneurs from among future social work specialists – this is the contradiction identified by the author. The desire to solve them determined the purpose of the study: to identify the ideas of future social work specialists about social entrepreneurship and their readiness to open a social enterprise. The theoretical analysis of the scientific literature indicates that social entrepreneurship is underdeveloped in domestic social practice. However, the infrastructure supporting social entrepreneurship has been specified; highlighted the role of universities in the training of social entrepreneurs; the prospects for the results of professional training of social entrepreneurs are determined. The article provides a secondary analysis of the results of foreign and domestic researchers who studied students' ideas about social entrepreneurship. The author's survey was conducted on the basis of Samara University. The sample consisted of future social work specialists (68 people). Conclusions are drawn about the poorly formed ideas of future social work specialists about social entrepreneurship. Interest in social entrepreneurship was noted. The common features of social entrepreneurship and social work are highlighted. The importance of entrepreneurial skills for a social worker is recognized. “Helping people” appears to be the main motive for the potential opening of a social enterprise, according to the results of the survey.
The Eukaryotic Last Common Ancestor Was Bifunctional for Hopanoid and Sterol Production
Authors: Francis Warren
Published: July 2022

Steroid and hopanoid biomarkers can be found in ancient rocks and may give a glimpse of what life was present at that time. Sterols and hopanoids are produced by two related enzymes, though the evolutionary history of this protein family is complicated by losses and horizontal gene transfers, and appears to be widely misinterpreted. Here, I have added sequences from additional species, and re-analysis of the phylogeny of SHC and OSC indicates a single origin of both enzymes among eukaryotes. This pattern is best explained by endosymbiotic acquisition of both enzymes from a bacterial ancestor, followed by widespread loss of SHC, and two subsequent HGT events to ferns and ascomycetes. Thus, the last common ancestor of eukaryotes would have been bifunctional for both sterol and hopanoid production. Later enzymatic innovations allowed diversification of sterols in eukaryotes. Contrary to previous interpretations, the last eukaryotic common ancestor (LECA) potentially would have been able to produce hopanoids as a substitute for sterols in anaerobic conditions. Without invoking any other metabolic demand, the LECA could have been a facultative aerobe, living in unstable conditions with respect to oxygen level.
Perspectives on the Use of Transthoracic Echocardiography Results for the Prediction of Ventricular Tachyarrhythmias in Patients with Non-ischemic Cardiomyopathy
Authors: Ilov N. N. , Stompel D. R. , Boytsov S. A. , Palnikova O. V. , Nechepurenko A. A.
Published: July 2022

Aim. To perform a comparative analysis of indicators of transthoracic echocardiography (TE), to establish echocardiographic predictors and their predictive role in the occurrence of stable ventricular tachyarrhythmia (VT) paroxysms in patients with nonischemic chronic heart failure (HF) and cardioverter-defibrillator (ICD) implanted for primary prevention of sudden cardiac death.

Material and Methods. A prospective study was carried out, which included 166 patients with nonischemic HF at the age of 54 (49; 59) years with the left ventricle ejection fraction (LV EF) ≤35% and an ICD implanted. The observation time was 24 months. The primary endpoint was the first-ever stable paroxysm of VT (lasting for ≥30 seconds), detected in the «monitor» zone of VT, or paroxysm of VT, which required ICD therapy.  A total of 34 TE indicators were evaluated. Chi-square, Fischer, Manna-Whitney, single-factor logistic regression (LR), and multi-factor LR were used for data processing and analysis and for predictive modelling. Model accuracy was estimated using 4 metrics: ROC curve area (AUC), sensitivity, specificity and diagnostic efficiency.

Results. During the two-year observation, 32 patients (19.3%) had a primary endpoint. The average time of occurrence of a stable VT episode was 21.6±0.6 months (95% confidence interval [CI] 20.5-22.8 months). The value of LV end-systolic dimension was the only parameter independently associated with VT (odds ratio 2.8 per unit increase, 95% CI 1.04-7.5; p=0.042). The complex analysis of echocardiographic indicators made it possible to identify 5 factors with the greatest predictive potential, which are linearly and nonlinearly related to occurrence of VT. These included the LV end-diastolic and end-systolic volumes, LV mass, index of relative LV wall thickness, upper-lower size of the right atrium. The metrics of the best predictive model were: AUC – 0.71 0.069 with 95% CI 0.574-0.843; specificity 50%, sensitivity 90.9%; diagnostic efficiency 57.1%.

Conclusion. The study made it possible to evaluate the possibilities of the results of TE in predicting the probability of VT occurrence in patients with nonischemic HF and reduced LV EF. Predictive indicators have been identified that can be used to stratify the arrhythmic risk in the exposed cohort of patients.
Risk of Venous Thromboembolic Complications in Patients with Atrial Fibrillation: a Systematic Review and Meta-analysis
Authors: Sokolova A. A. , Kudriavtseva A. A. , Kostokova N. V. , Zaikina M. P. , Gebekova Z. A. , Napalkov D. A. , Zolotukhin I. A.
Published: July 2022

Aim: The aim of this meta-analysis and systematic review was to evaluate the possible connection between AF and VTE.

Material and methods. Atrial fibrillation (AF) and atrial flutter (AFL) contribute to intra-atrial blood stasis which leads to thrombus formation with its embolization. There is some evidence that AF can be a risk factor for deep vein thrombosis (DVT) and pulmonary embolism (PE). The following databases were searched: PubMed (MEDLINE), EMBASE, Google Scholar, the Cochrane Central Register of Controlled Trials. The time frame for conducting a systematic literature search ranged from January 1, 1990 to November 1, 2021. The diagnosis of atrial fibrillation had to be confirmed by using ECG. The diagnosis of VTE could be made with Doppler imaging, ventilation/perfusion scan, CT angiography, venography, angiography or autopsy. Only the three studies with 102192 patients meeting the requirement were included in the meta-analysis.

Results. The prevalence of DVT and PE were assessed using incidence rate ratios (IRR) method of the inverse variance random effects model and its 95% confidence interval (CI). The significant association between atrial fibrillation and pulmonary embolism was found (IRR, 4.18 95% Cl 1.958.98). Also there is obvious association between DVT and AF (IRR, 2.97 95% Cl 2.18-4.03).

Conclusion. It can be concluded that the increased risk of developing VTE is associatedwith concomitant AF.
Association of Heart Rate Variability with the Psychosocial Stress Level in Men 41-44 Years Old Living in Moscow
Authors: Drapkina O. M. , Rozanov V. B. , Kontsevaya A. V. , Isaykina O. Yu. , Muromtseva G. A. , Kotova M. B. , Akarachkova E. S.
Published: July 2022

Aim. Research of the association of heart rate variability (HRV) with the level of psychosocial stress (PS) and other indicators of the risk of cardiovascular diseases in a sample of 41-44-year-old men living in Moscow.

Material and methods. A total of 299 men aged 41-44 years were examined. The study included a clinical examination and a survey using a standard questionnaire. The categorization of risk factors (RF) for cardiovascular diseases (CVD) was carried out in accordance with generally accepted criteria The psychosocial stress was assessed using the Reeder scale. Depending on the psychosocial stress level, all surveyed men were divided into 3 groups by terciles: group 1 (3,28-4,0 points) – mild stress, group 2 (2,71-3,14) – moderate stress, group 3 (1,28-2,57) – severe stress. The analysis of HRV was performed on the basis of a short recording of an electrocardiogram using the original software package.

Results. Nonparametric ANOVA showed that the mean [M (95% CI)] values of the HRV time domain (SDNN, rMSSD and the state of regulatory reserves) were lower in the group of men with high PS compared with the group with low PS [25.3 ms (20.9-29.7) versus 40.5 ms (30.7-50.3), p=0.007; 29.5 ms (24.6-34.3) versus 49.5 ms (36.7-62.3), p=0.030; and 46.7 (44.7-48.6) versus 49.7 (48.1-51.4), p=0.019; respectively]. On the contrary, the mean values [M (95% CI)] of the integral indicators of HRV (SI and IVR) were higher in the group of men with high PS [635.8 c.u. (556.2-715.4) versus 488.9 (423.8-554.1), p=0.005; 1172.6 (1045.1-1300.1) versus 904.7 (790.0-1019.4), p=0.003; respectively]. The results of correlation and multiple regression analysis confirmed that these HRV indicators are statistically significantly associated not only with PS, but also with other indicators (age, waist / hip ratio, diastolic blood pressure). However, their predictive value turned out to be low, and the proportion of the explained variance of HRV indices ranged from 2.5 to 13.1%.

Conclusion. The weakening of the autonomous regulation of the heart rate with a decrease in the activity of the parasympathetic link, the activation of the central circuit of regulation with the prevalence of sympathetic influences, a decrease in the functional reserves of the heart rate regulation system are associated with an increase in the level of PS and other indicators of the risk of cardiovascular diseases.
Self-care as the Basis of the Mobile Application for Patients with Chronic Coronary Syndromes
Authors: Laskova A. I. , Frolov M. Yu. , Orlova Yu. A. , Lopatin Yu. M.
Published: July 2022

Aim.To evaluate the impact of a mobile application usage on the self-care skills, quality of life, adherence to treatment, as well as the psychological characteristics of comorbid patients with stable coronary heart disease.

Material and methods. The study will include patients over 18 years of age with an established diagnosis of ischemic heart disease, exertional angina pectoris I-IV CCS functional class, who have the technical ability to use the mobile application "B2Doc: Angina" on their smartphone. This mobile application contains main components of recommendations for the management of coronary heart disease and monitoring of patient’s well-being. The program is based on the previously developed and validated questionnaire of the self-care ability of patients with coronary artery disease. The mobile application includes advice of the day, tracking the dynamics of angina pectoris symptoms, blood pressure and pulse, a medication diary as well as educational material about coronary heart disease. The study will assess quality of life: general (SF-36) and angina-related (Seattle Angina Questionnaire), self-care skills using the Self-Care of Coronary Heart Disease Inventory questionnaire. The primary endpoints will be cardiovascular events (cardiovascular death, acute myocardial infarction, acute cerebrovascular accident, hospitalization with unstable angina or decompensated chronic heart failure) and death from all causes. Endpoints will be evaluated in 1, 3, 6 and 12 months after discharge.

Expected results. We expect that the use of the mobile application "B2Doc: Angina" by patients will improve their self-care skills and quality of life, as well as increase awareness of the disease.

Conclusions. The use of the newly developed mobile application "B2Doc: Angina" is a potential tool for the prevention and treatment of coronary heart disease. It represents a promising solution for the rapid implementation and expansion of telemedicine practice.
Lipid profile of patients with arterial hypertension who underwent COVID-19: possibilities of drug therapy/ LEADER
Authors: Zolotovskaya I. A. , Kuzmin V. P. , Rubanenko O. A. , Shatskaya P. R. , Salasyuk A. S.
Published: July 2022

Aim.To study the dynamics of the lipid profile of hypertensive patients with dyslipidemia who underwent COVID-19.

Material and methods. Hypertensive patients with dyslipidemia who underwent COVID-19 [n=126; 58 men and 68 women; median age 60 (56.0; 65.5) years] examined. Patients were included into two groups: group 1 (n=64) received a single pill combination of lisinopril + amlodipine + rosuvastatin; 2 groups (n=62) continued the previous drug treatment. Clinical, demographic, office blood pressure (BP), total cholesterol (TC), low density lipoprotein cholesterol (LDL-c), high density lipoprotein cholesterol, triglycerides, C-reactive protein (CRP) levels were assessed in all patients in 3 visits within 24 weeks.

Results.The groups did not differ in prior antihypertensive therapy (except for more frequent use of angiotensin II receptor blockers in group 2, p<0.05), lipid profile and blood pressure parameters at study entry. A decrease in systolic (by 9.5%) and diastolic blood pressure (by 12.1%) after 24 weeks was found in group 1 compared with 4.29% and 5.56%, respectively, in group 2 (p<0.05). A decrease in the level of total cholesterol by 14.5% and LDL-c by 31.4% after 24 weeks was found in group 1 compared with 11.2% and 9.7%, respectively, in group 2 (p<0.05). The level of CRP during the observation period decreased by 53.7% in group 1 versus 43.4% in patients of group 2 (p<0.05).

Conclusion.The single pill combination of lisinopril/amlodipine/rosuvastatin in hypertensive patients with dyslipidemia who underwent COVID-19 led to an improvement in lipid profile and blood pressure control.
Dynamics of 6-Minute Walk Distance as a Predictor of Efficiency Specific Pulmonary Vasodilators
Authors: Shmalts A. A.
Published: July 2022

Pulmonary hypertension is a severe and often rapidly progressive disease with a fatal outcome. Approved specific therapy with five classes of drugs – prostanoids, endothelin receptor antagonists, phosphodiesterase-5 inhibitors, soluble guanylate cyclase stimulators and prostacyclin receptor agonists has significantly improved the prognosis of patients. An accessible and reproducible criterion of exercise tolerance – a distance walked in six-minute walk test (6MXD) – occupies one of the central places among the performance indicators (clinical, echocardiographic and hemodynamic) of specific pulmonary vasodilators. Reflecting the clinical severity of pulmonary hypertension and, according to some data, its long-term prognosis, the dynamics of 6MXD is an integral component of the combined primary endpoints of randomized controlled trials. In the CHEST-2019 recommendations, the dynamics of the 6MXD was used to standardize the randomized controlled trials. The 6MXD is indispensable for dynamic observation and decisionmaking on further treatment tactics
Assessment of the Quality of Drug Therapy in Patients with Stable Coronary Artery Disease in the Second Stage of the ALIGN Study
Authors: Zharkova E. D. , Martsevich S. Yu. , Lukina Yu. V. , Kutishenko N. P. , Drapkina O. M.
Published: July 2022

Aim. To assess adjusted pharmacotherapy for prescribing drugs of the main classes, according to clinical guidelines, and achieving target levels of lowdensity lipoprotein cholesterol (LDL-C) in patients with stable coronary heart disease (CHD).

Material and methods. Of the 73 patients included in the ALIGN study, 64 patients (53 males and 11 females; mean age 68,2±9,4 years) with stable coronary artery disease attended a second visit (3 months after the initial treatment adjustment). Prescribed drug therapy, its compliance with clinical guidelines, achievement of lipid profile and blood pressure (BP) targets were studied in all patients.

Results. An increase in the frequency of taking beta-blockers (p=0.002), lipid-lowering drugs (p=0.008) by patients was found during the second visit. The proportion of patients taking all 4 groups of drugs according to clinical guidelines (statins, antiplatelet agents, beta-blockers, angiotensinconverting enzyme inhibitors / angiotensin II receptor blockers) increased from 44% to 65.5% (p<0.001) after correction of therapy, as well as an increase in the proportion of patients taking 1 antianginal drug in the presence of exertional angina from 75% to 89% (p<0.001) was found. About 90% of hypertensive patients achieved the target level of systolic blood pressure (p<0.001). Achievement of the target level of cholesterol low density lipoprotein (<1.8 mmol/l) during the second visit was found in half of the patients (p=0.004).

Conclusion. Despite the initial correction of drug therapy by the staff of the cardiology department, the prescribed treatment for patients with stable coronary artery disease did not in all cases comply with clinical guidelines due to insufficient adherence of doctors and insufficient adherence of patients to prescribed medical recommendations.

Working group of the register PROFILE: Voronina V. P., Dmitrieva N. A., Komkova N. A., Zagrebelny A.V., Kutishenko N.P., Lerman O.V., Lukina Yu. V., Tolpygina S.N., Martsevich S.Yu.
Coagulation Disorders in Infective Endocarditis: Role of Pathogens, Biomarkers, Antithrombotic Therapy (Systematic Review)
Authors: Pisaryuk A. S. , Zamarashkina V. A. , Safarova N. B. , Povalyaev N. M. , Kotova E. O. , Babukhina U. I. , Koltsova E. M. , Kobalava Zh. D.
Published: July 2022

The issue of antithrombotic therapy in patients with infective endocarditis has been studied for over 75 years. During that time studying of pathogenesis of the disease and its embolic complications, lead to the introduction of the concept of “immunothrombosis”. That mechanism allows infective agents (mostly bacteria) to be cloaked from the immune system and to multiply freely, leading to growth of vegetation, thus resulting in higher chance of fragmentation. Small-scale experimental and clinical studies on the correction of hemostatic disorders in infective endocarditis, that were performed in 20th century, didn’t show any significant results, that could affect clinical practice. However, reinterpretation of available data on coagulative system will allow to have elements of hemostasis as an application point in treating infective endocarditis. The article will discuss latest insights on the role of hemostasis system in pathophysisology of infective endocarditis, its effects on the development of the embolic complications, perspectives for diagnostics and treatment.
Study the Association of Nucleotide Polymorphisms in Platelet Receptor and Cytochrome P450 Genes with the Development of Resistance to Antiplatelet Drugs in Patients with Coronary Artery Disease
Authors: Semashchenko K. S. , Mongush T. S. , Kosinova A. A. , Subbotina T. N. , Grinshtein Y. I.
Published: July 2022

Aim. To study the association of nucleotide polymorphisms in platelet receptor and cytochrome P450 genes with the development of resistance to antiplatelet drugs in CHD patients.

Material and Methods. The study included 243 patients diagnosed with CHD after coronary artery bypass surgery (CABG), including 140 patients in the acetylsalicylic acid (ASA) treatment group and 103 patients in the dual antiplatelet therapy (DAT) group. All patients were tested for platelet aggregation using an optical aggregometer with inducers: 5 mM ADP and 1 mM arachidonic acid (AA). DNA samples were analyzed by allele-specific PCR for the presence of polymorphisms rs2046934, rs1126643, rs5918, rs6065, rs4244285 in the platelet receptor and cytochrome P450 genes.

Results. No statistically significant differences were found during comparison of the prevalence of the studied polymorphisms in the platelet receptor and cytochrome P450 genes between the groups of aspirin-sensitive and aspirin-resistant patients, as well as between the groups of clopidogrelsensitive and clopidogrel-resistant patients. No association between carriage of the minor and major alleles of the polymorphisms studied and the development of antiplatelet drug resistance was found. In the group of patients on ASA therapy, carriers of the C allele of the T1565C (rs5918) ITGB3 polymorphism had a higher rate of AA-induced platelet aggregation compared to carriers of the T allele (18,49±25,92 vs 10,43±17,34, р=0,004).

Conclusion. Polymorphisms of P2RY12 (rs2046934), ITGA2 (rs1126643), ITGB3 (rs5918), GP1BA (rs6065), CYP2C19*2 (rs4244285) genes are not associated with antiplatelet drug resistance in both patients on ASC therapy and on DAT. The presence of minor alleles of the rs2046934, rs1126643, rs6065, rs4244285 polymorphisms are not associated with increased platelet aggregation activity before CABG.However, in the group of patients on ASA therapy C-allele carriers of the rs5918 polymorphism of the ITGB3 gene had a higher rate of AA-induced platelet aggregation compared to T-allele carriers.
National Sediment Placement Data Viewer users guide
Authors: Emery Benjamin
Published: July 2022

This US Army Corps of Engineers (USACE) Regional Sediment Management (RSM) technical note serves as a user’s guide for the RSM National Sediment Placement Data Viewer. This application was created utilizing over 20 yr* of detailed and verified USACE dredging data, giving users an interactive web-based tool that takes these datasets and displays them on a national map, viewable at the district or project scale. The Data Viewer will quantify the total cubic yards dredged, disposed, and/or beneficially used based on the user selected parameters. Detailed information on the datasets utilized and the verification processes followed to create this application can be found in ERDC/TN RSM-22-XX, USACE Navigation Sediment Placement: An RSM Program Database (1998 – 2019) (Elko et al. 2022). This technical note attempts to define each of the inputs/outputs given from the Data Viewer and then provide a step-by-step example of utilizing the Data Viewer, accessed here: https://www.arcgis.com/apps/MapSeries/index.html?appid=0ea8fc0a956f46068428c862e7497233
USACE Navigation Sediment Placement : An RSM Program Database (1998 – 2019)
Authors: Elko Nicole , Brutsché Katherine , Robertson Quin , Hartman Michael , Dong Zhifei
Published: July 2022

This US Army Corps of Engineers, Regional Sediment Management, technical note describes a geodatabase of federal coastal and inland navigation projects developed to determine the extent to which RSM goals have been implemented across the USACE at the project and district levels. The effort 1) quantified the volume of sediment dredged from federal navigation channels by both contract and USACE-owned dredges and 2) identified the placement type and whether sediment was placed beneficially. The majority of the dredging data used to populate the geodatabase were based on the USACE Dredging Information System DIS database, but when available, the geodatabase was expanded to include more detailed USACE district-specific data that were not included in the DIS database. Two datasets were developed in this study: the National Dataset and the District-Specific and Quality-Checked Dataset. The National Dataset is based on statistics extracted from the combined DIS Contract and Government Plant data. This database is a largely unedited database that combined two available USACE datasets. Due to varying degrees of data completeness in these two datasets, this study undertook a data refinement process to improve the information. This was done through interviews with the districts, literature search, and the inclusion of additional district-specific data provided by individual districts that often represent more detailed information on dredging activities. The District-Specific and Quality-Checked Database represents a customized database generated by this study. An interactive web-based tool was developed that accesses both datasets and displays them on a national map that can be viewed at the district or project scale.
Validation of the automatic dynamic cone penetrometer
Authors: Berney Ernest , Daugherty Jami Lynn , Edwards Lulu
Published: July 2022

The U.S. military requires a rapid means of measuring subsurface soil strength for construction and repair of expeditionary pavement surfaces. Traditionally, a dynamic cone penetrometer (DCP) has served this purpose, providing strength with depth profiles in natural and prepared pavement surfaces. To improve upon this device, the Engineer Research and Development Center (ERDC) validated a new battery-powered automatic dynamic cone penetrometer (A-DCP) apparatus that automates the driving process by using a motor-driven hammering cap placed on top of a traditional DCP rod. The device improves upon a traditional DCP by applying three to four blows per second while digitally recording depth, blow count, and California Bearing Ratio (CBR). An integrated Global Positioning Sensor (GPS) and Bluetooth® connection allow for real-time data capture and stationing. Similarities were illustrated between the DCP and the A-DCP by generation of a new A-DCP calibration curve. This curve relates penetration rate to field CBR that nearly follows the DCP calibration with the exception of a slight offset. Field testing of the A-DCP showed less variability and more consistent strength measurement with depth at a speed five times greater than that of the DCP with minimal physical exertion by the operator.
Análise do Racismo Estrutural como Componente da Ineficiência do Estado e das Políticas Públicas
Authors: Azevedo Pimenta Carlos Eduardo
Published: July 2022

O racismo está presente desde a antiguidade em praticamente todas as civilizações conhecidas, sobrevivendo de maneira perceptível até o início do Século XXI, o que no âmbito social resulta em exclusão socioeconômica e cultural e, no âmbito da ação estatal, resulta em entraves para que as políticas públicas inclusivas atinjam seus resultados. Este ensaio analítico, com base em revisão da literatura recente sobre as implicações do racismo na implementação das políticas públicas no Brasil, tem como seu principal objetivo apresentar reflexão sobre a relação entre práticas ilegais e corrupção de agentes públicos, e o racismo estrutural, pois é fato notório que no Brasil o aparato jurídico penal privilegia as classes brancas e ricas, criminalizando e culpabilizando os negros e periféricos, o que de per se insere no núcleo do Estado a política de dois pesos e duas medidas, chave para a manutenção de práticas ilegais no bojo do serviço público. Conclui-se que, que para além de múltiplas políticas públicas de redução da desigualdade que venha a ser criadas, é necessário instituir-se na ação das organizações dos trabalhadores e dos excluídos o incentivo de candidaturas competitivas de negros, indígenas, trabalhadores e trabalhadoras, que fujam do estereótipo ‘candidato branco, hétero, empresário, classe média/alta’, levando ao poder representantes da maioria da sociedade brasileira, composta de negros e pardos das classes C, D e E.
Microscópio Portátil Baseado em Dispositivo Móvel: Tecnologia alternativa de baixo custo para fins didáticos
Authors: Pauli Guilherme , CAVALI Guilherme , WOLFART JR. Meinardo , WOLFART JR. Mario
Published: July 2022

Embora a educação brasileira tenha passado por um grande crescimento em termos demográficos e de investimento público no período 2003-2014, os últimos resultados do exame internacional Pisa 2018 colocam o Brasil apenas em 57º lugar, demonstrando as dificuldades enfrentadas por instituições e políticas públicas para promover aprendizado de qualidade. Entre outras razões apontadas para o problema, apenas 44% das escolas de ensino médio contam com laboratórios de ciência no país, um dado alarmante tendo em vista o consenso em torno das aulas experimentais em laboratórios para construção do conhecimento em áreas como Física, Química e Biologia, o que é inviabilizado em parte devido ao alto custo dos equipamentos. O avanço da tecnologia dos Smartphones, contudo, apresenta inúmeras novas possibilidades para técnicas e métodos de construção de equipamentos para laboratórios, tendo em vista o baixo custo dos telefones celulares e o vasto número de aparelhos Smartphone existentes atualmente no Brasil. Este trabalho apresenta resultados de um projeto voltado a construir um microscópio portátil com base em telefone celular, para ser usado em aulas experimentais do ensino médio nas escolas públicas brasileiras. O projeto, baseado em manufatura aditiva, utiliza como câmera um Smartphone comum, e conta com sistemas de regulagem e adaptações para os mais diferentes estilos e modelos de celular. Espera-se que o equipamento seja empregado em situações onde não há necessidade de maior aproximação para análise dos materiais observáveis.
ANN AND FA Based Wearable Hybrid Fractal Antenna Using Split Rings for Wireless Applications
Authors: S Sandeep Singh , Sivia Jagtar Singh
Published: July 2022

A distinct, ANN and FA-based Wearable Hybrid Fractal Antenna using Split Rings (WHFASR) is explored in this manuscript. The textile substrate chosen for WHFASR is jean having a dielectric constant of 1.7, thickness 1 mm and dimensions 51 x 51 x 1 mm3. The Meander and Koch curves are merged using a mathematical tool Iterative Function System (IFS) for achieving better performance and miniaturization for the designed antenna. ANN demonstrating gives a promising arrangement, particularly for taking care of different issues that are generally experienced in science and engineering. Using the Firefly algorithm (FA) the feed position of the designed antenna is optimized. For implantation of ANN and FA approaches, a data set of 50 WHFASR is generated by varying the feed position using parametric analysis in HFSS software. The proposed WHFASR exhibits two resonant frequency bands 2.44 and 5.01 GHz and S (1, 1) < -10 dB are observed at these resonant frequencies. The proposed WHFASR is manufactured and experienced using Vector Network Analyzer (VNA) and the simulated and experimental outcomes are compared to observe the reliability of the WHFASR.