bluuebunny/crossref_metadata_2025 huggingface dataset:
Credit usage, payment behavior, and the accuracy of consumer credit files
Authors: Smith L. Douglas , Staten Michael , Eyssell Thomas , Karig Maureen , Feinstein Jeffrey , Johnson Cathleen
Published: November 2023

Through intensive interviews, examination of credit reports, and rescoring of corrected credit files, the researchers consider household characteristics, major life events, financial resources, and payment habits as they study the integrity of credit-bureau data, vulnerability to error, and results of disputes filed with the major credit bureaus. Credit usage and management are found to vary widely within demographic groups. Vulnerability to error and outcomes of disputes depend primarily on the credit record itself. Consumers with moderate credit scores are more likely than those with very high or low scores to see significant improvement in their records when errors are corrected.
Factors related to the risk tolerance of households in China and the United States
Authors: Hanna Sherman D. , Kim Kyoung Tae , Zhang Lishu
Published: November 2023

We analyzed factors related to the financial risk tolerance of Chinese households, using the 2011 China Household Finance Survey (CHFS). The risk tolerance question was similar to one in the U.S. Survey of Consumer Finances (SCF), and we found that CHFS respondents had slightly higher risk tolerance than SCF respondents, but the percentage of households with stock assets was 9%, compared with 49% in the United States. Our multivariate analyses found many household characteristics in the CHFS had effects on risk tolerance similar to those found in the 2013 SCF. We discuss implications for the future of Chinese investment markets.
seducción de Georgina Hübner
Authors: Meza Parra Héctor
Published: November 2023

La presente investigación inicia con el objetivo de identificar la historia de amor entre el poeta español Juan Ramón Jiménez y José Gálvez Barrenechea. El enfoque presentado es el cualitativo con método hemerográfico y biográfico. El principal resultado encontramos cuando José Gálvez escribió hermosas cartas de admiración bajo el sonoro nombre de Georgina Hübner con el propósito de obtener el libro de poesías Arias tristes de autoría de Juan Ramón Jiménez. Este acontecimiento encendió las pasiones del poeta de Moguer quien estuvo a punto de zarpar a nuestras costas del Callao en 1904, tan solo para conocer a su musa y proponerle matrimonio. Concluimos el estudio manifestando que la historia de amor entre el poeta español Juan Ramón Jiménez y José Gálvez Barrenechea fue posible cuando este último escribió bajo el nombre de Georgina Hübner.
Biobibliografía de Jean D’Carval: escritor y poeta tarmeño
Authors: Goyas Baldoceda Ana María , Flores Poma Irina Giovanna , Cárdenas Flores Kimberly Johana , Cárdenas Flores Jean Edward
Published: November 2023

El presente estudio tiene por finalidad construir un registro biobibliográfico de Jean D’Carval: escritor y poeta tarmeño cuya obra literaria se ha manifestado a lo largo de muchos años en la región Junín y lo sitúa como uno de los intelectuales tarmeños más reconocidos debido a la apasionante como difícil oficio que ha asumido. Se precisa un orden cronológico de sus publicaciones del autor en los años que aparecieron y delineamos su influencia literaria más allá del espacio local. Metodológicamente asumimos el paradigma cualitativo, con estrategias del método biográfico y el análisis documental. Con el trabajo de análisis, contribuimos al conocimiento de su biobibliografía y ponemos en valor su obra creativa para que dicho intelectual sea leído en similares condiciones con otros poetas reconocidos de la región cuya obra se evidencia a partir de 18 textos de poesía, 9 textos de narrativa, 4 textos de ensayo, 2 textos de teatro sumando 31 textos.
Pengaruh Harga, Kualitas Produk, Kualitas Pelayanan dan Kepuasan Pelanggan Terhadap Loyalitas Pelanggan
Authors: Candra Eko , Ketut Sunaryanto
Published: November 2023

Customer loyalty can be an effective, competitive and efficient strategy for a brand or company, because it can strengthen customer trust in the brand. Customers assess perceived loyalty based on price, product quality, service quality and satisfaction felt when shopping. The purpose of this study was to determine the effect of price, product quality, service quality, satisfaction and loyalty on customers who shop for material products in Indonesia. This research was conducted on 120 respondents located in Indonesia who are customers of material companies or stores. Data were collected using questionnaires distributed online and offline in July 2023. To test the research model, this study used SPSS 25. So that the following data were obtained: price, product quality, service quality and customer satisfaction have a joint effect on customer loyalty, price has a positive effect on customer loyalty, product quality has a positive effect on customer loyalty, service quality has a positive effect on customer loyalty, customer satisfaction has a positive effect on customer loyalty.
Comparative Analysis of Brand Image between Lining and Victor Shoes Among Badminton Players in Gelanggang Remaja Koja, Jakarta
Authors: Natalia Desy Uli
Published: November 2023

In playing badminton, one of the supporting facilities used is badminton shoes (Fitantri, 2015). As well as protecting the feet, shoes can also prevent injury and acceleration when on the field. A common phenomenon related to brand image that usually appears is the feeling or impression that consumers get after using a brand. This study aims to determine the difference between the brand image of Lining shoes and Victor shoes according to Badminton players at the Koja Youth Center in Jakarta. The method used is a quantitative method with a comparative research type. The population in this study were all badminton players at the Koja Jakarta Youth Center, totaling 60 people. The research was conducted at the Koja Jakarta Youth Center in selecting the sample using a purposive sampling technique. Then, for data analysis used descriptive analysis and Paired T-Test. Based on the results of the Paired T-Test, the mean value of Lining's shoe brand image was 47.1500, then the mean value of Victor's shoe brand image was 51.8333. This shows that the brand image of Victor shoes is higher or better than the brand image of Lining shoes based on the results of research on 60 users of Lining shoes and Victor shoes who are badminton players at the Koja Youth Center in Jakarta.

Dalam bermain bulu tangkis sarana pendukung yang dipergunakan salah satunya adalah sepatu bulu tangkis (Fitantri, 2015). Selain sebagai pelindung kaki, sepatu juga dapat menghindari cedera dan percepatan pada saat di lapangan. Fenomena umum terkait brand image yang biasanya muncul yaitu perasaan atau kesan yang diperoleh konsumen setelah menggunakan suatu merek. Penelitian ini bertujuan untuk untuk mengetahui perbedaan antara brand image sepatu Lining dan sepatu Victor menurut pemain Badminton di Gelanggang Remaja Koja Jakarta. Metode yang digunakan adalah metode kuantitatif dengan jenis penelitian berupa komparatif. Populasi dalam penelitian ini adalah seluruh pemain badminton yang di Gelanggang Remaja Koja Jakarta yang berjumlah 60 orang. Penelitian yang dilakukan di Gelanggang Remaja Koja Jakarta dalam pemilihan sampel menggunakan teknik purposive sampling. Kemudian, untuk analisis data digunakan analisis deskriptif dan Uji Paired T-Test. Berdasarkan hasil uji Paired T-Test nilai mean brand image sepatu Lining yaitu 47,1500 kemudian nilai mean brand image sepatu Victor yaitu 51,8333. Hal ini menunjukkan bahwa brand image sepatu Victor lebih tinggi atau lebih baik daripada brand image sepatu Lining berdasarkan hasil penelitian kepada 60 orang pengguna sepatu Lining dan sepatu Victor yang merupakan pemain badminton di Gelanggang Remaja Koja Jakarta.

Kata Kunci: Brand Image, Lining, Victor
Study of the Potential Utilization of Solar Energy at Village Head Office Paluh Manis Langkat
Authors: Rahmaniar  , Aji Prayogo  , Rio Pratama  , Ryan Fahrezie Siswanto
Published: November 2023

New and renewable energy continues to develop in the territory of Indonesia, one of the renewable energy discussed is solar power generation. The potential of Solar Electric Energy in Paluh Manis village is quite large with the condition of the area located on the coast, with an average temperature of 32C. The electricity demand at the office of the village head of paluh manis of 3300 KW is the center of research that will be the center of research if the electricity demand at the office of the village head of paluh manis langkat is diverted from the source of the State-Owned Company into a solar power plant. The results of observations and analysis produced that the electrical load requirements in the village of paluh manis with the following details: 2 x 6 = 12 100 Ah batteries, 8x 100 wp Solar Modules, 60 A charger controller, 1000 watt Inverter. Installation of solar power plants in offices at a cost of Rp. 25,700,000 with a service life of 20 years can be a great potential and can be recommended as the utilization of new and renewable electrical energy.
Video-Assisted Transumbilical Appendectomy Compare to Laparoscopic and Open Appendectomy in Children
Authors:   Pediatric Surgery Department, Ha’emek Medical Center, Afula, Israel, Yardeni Dani , Golladay Steve E ,   Mott Children’s Hospital, University of Michigan, Ann Arbor, MI, USA
Published: November 2023

Aim: Video-assisted transumbilical appendectomy (VATA) is a combination of laparoscopic appendectomy (LA) and open appendectomy (OA) that has the potential advantages of both techniques. In this study we report our recent experience with VATA and compare it to our experience with OA and LA. Methods: The charts of all the children who underwent VATA between March 2006 and July 2008 were retrospectively reviewed and compared to those who had OA or LA between from July 2002 and October 2003 in our department. Children who present with a preoperative diagnosis of acute appendicitis and children who electively admitted for an interval appendectomy were candidates. One 12-mm trocar was inserted transumbilical. An operating laparoscope was used to mobilize the appendix, which was delivered through the umbilicus, and a standard extracorporeal appendectomy was performed. The results in VATA were compared to our results with OA and LA that was published in 2007. Results: Of 129 children who underwent appendectomy, 58 had VATA, 52 OA and 19 LA. Of the 58 children who had VATA, 42 were performed for treating acute appendicitis and 16 as an interval appendectomy after conservative treatment of complicated appendicitis. The operating time was significantly longer for LA than for VATA and OA. The length of stay (LOS) was significantly shorter after VATA or LA than after OA. A lower percentage of children who underwent VATA needed MO than after LA and OA and children after VATA had to be statistically significant fewer days on NPO. There were no death or severe complications during or after any of the operations and there were no statistically significant differences regarding the complications between the groups. Conclusions: Video-assisted transumbilical appendectomy is a safe, fast and inexpensive technique which combines the advantages of both OA and LA. The use of one trocar and extracorporeal Appendectomy make VATA, Less invasive, Easer, Faster and Cheaper.
National Early Warning Score 2. to Identify Sepsis in the Emergency Department. A Review of the Literature
Authors:   Nurse, ASST Rhodense, Rho, Italy, Marosi Veronica , Gadda George ,   Nursing Coordinator, Niguarda Hospital, Milan, Italy, Timoftica Claudia ,   Nursing Coordinator, ASST Rhodense, Rho, Italy, Alberti Annalisa ,   Nursing Coordinator, ASST Rhodense, Rho, Italy, Destrebecq Anne ,   Full Professor of Nursing Sciences - University of Milan, Milan, Italy
Published: November 2023

Aims: The aim of this study is to understand the described sensitivity and specificity in the literature of the NEWS2 score to identify early patients at developmental risk for sepsis through the use of the score in the intra-hospital triage phase, comparing it with the diagnostic accuracy of qSOFA: Quick Sequential [Sepsis-related] Organ Failure Assessment for sepsis with organ dysfunction, infection-related mortality, or ICU due to infection, especially in patients by priority code level 3, 4, and 5 as levels 1 and 2 represent absence or rapid deterioration of one or more vital functions and risk of impairment of vital functions, respectively. Materials and Methods: The study is based on a literature review by querying four databases, including PubMed, Cinahl, Embase, and Cochrane Library and the Guidelines of the Regional Health Council of Tuscany Region (2016). The study also asks a question: Does the use of the NEWS 2 early warning system in intrahospital triage lead to early recognition and treatment of patients at high risk for sepsis? Results: The NEWS is more accurate in predicting mortality or ICU admission due to infection within 72 hours than qSOFA and SIRS in patients suspected of sepsis at initial presentation to the emergency department. This will potentially aid in the early diagnosis of all patients at risk for ED deterioration, including those at risk for sepsis-related mortality. Conclusions: The use of NEWS 2 is important because of the predictive power of urgent priority, increasing the ability to discriminate patients who may be worsening their condition, despite a priori being otherwise classified. Implementation of the NEWS 2 among hospital-wide triage procedures effectively predicts early mortality and detects high- risk patients.
The role of autophagy in cardiac damage
Authors:   Omsk State Medical University, Zolotova S.A. , Palyanov S.V. ,   Omsk State Medical University
Published: November 2023

Autophagy is one of the mechanisms ensuring cell homeostasis on the one hand, and on the other hand, it is a way of utilizing damaged cell structures through their autolysis in the autophagosome for reuse in cell metabolism. Autophagy is usually considered as an adaptive process allowing cells to survive under conditions of stress, nutrient deficiency and hypoxia. However, under certain circumstances autophagy can be the cause of cell death. Cell death accompanied by autophagy activation and autophagosome accumulation has been classified as programmed cell death type II. However, compared to detailed information on the adaptive role of autophagy, its involvement in cell death has been poorly understood. Autophagic cell death can be divided into two groups, namely: (1) autophagic cell death with increased autophagy activity; (2) autophagic cell death with decreased autophagy processes. In the first scenario, autophagy is excessively activated, causing uncontrolled autolysis of cellular structures and cell death. A similar scenario is observed in cell death caused by excessive degradation of damaged organelles in lysosomes. Of particular interest is a specific form of autophagy in which damaged mitochondria are excessively eliminated from the cell - mitophagy. Autophagic cell death is characteristic of diabetic cardiomyopathy. The second variant, characterized by reduced autophagy processes, is observed in doxorubicin-induced cardiomyopathy, autophagy during ischemia/reperfusion and autophagic cell death in lysosomal accumulation diseases. In this scenario, the final step of autophagy is usually disrupted, and an imbalance between autophagosome formation and lysosomal activity leads to massive autophagosome accumulation, which subsequently causes cellular dysfunction and death. Dysregulation of autophagy causes a unique form of cell death, called autosis, with certain morphological and biochemical features that differ from other forms of cell death, such as apoptosis and necrosis. In autosis, Na+/K+ ATPase plays a special role, which by physically interacting with Beclin 1 can promote autophagic cell death. The principles of therapeutic intervention aimed at preventing autophagic death of cardiomyocytes depend on the specific mechanisms of autophagy. For example, the use of Na+/K+-ATPase inhibitors, such as cardiac glycosides, provides a cardioprotective effect by inhibiting autophagy, while the use of trehalose and 3,4-dimethoxychalcon, can optimize autophagy processes and reduce the intensity of excessive autophagosome accumulation. Thus, the study of mechanisms of autophagy and search for new approaches in pharmacocorrection and pharmacoprophylaxis of autophagic cell death are actual directions of modern scientific research. The aim of the review is to present the concept of autophagic cell death in some heart diseases.
OPTIMALISASI APLIKASI MENDELEY SEBAGAI SARANA PENELITIAN DI SEKOLAH TINGGI TEOLOGI TABGHA BATAM
Authors: Mendrofa Feri Aman , Pasaribu George Rudi Hartono
Published: November 2023

Skills in using technology facilities and applications are indispensable in the preparation of research journals and dedication to lecturers at the Tabgha Theological Seminary of Batam, especially for journal publications that meet publication standards. The use of the right application is an effort made to meet the above standards, therefore Tabgha Theological Seminary Batam uses the tools available in the Mendeley application. In this service, the method applied is by holding Mendeley application training which contains an introduction to the Mendeley application and its benefits, installation steps on lecturer computers, installation on Microsoft Word, application of citations and bibliography. The result of this training is that lecturers can optimally use the Mendeley application so that they can present journal publications that meet predetermined standards and templates. The results of the Community Service questionnaire initially found that only 25% had Mendeley installed;

12.5% ​​already have a Mendeley account and 12.5% ​​are able to use Mendeley in various research reports, and after training 100% of the lecturers have installed, have an account and are able to use the Mendeley Application proficiently.
WORKSHOP MANAJEMEN PUBLIKASI PENELITIAN DAN PENGABDIAN BERBASIS OJS DI ST3B
Authors: Silitonga Frangky , Suhendra  , Pasaribu George Rudi Hartono , Steven  , Suryady Robertus
Published: November 2023

In this workshop, the publication of scientific writing for research and service based on OJS uses OJS V.3.3 from PKP. The OJS that have been owned by ST3B are OJS Tabgha, Imparta and Beatitudes, these OJS are the objects of this service. In this activity, the devotees collaborate on two different institutions, between Karimun University and ST3B, this was done as a forum for detecting the detailed needs of ST3B for publications. The service methods used are interview, role play and demonstrative as well as direct practice using a personal account on OJS that has been registered at every OJS ST3B. The results obtained are participants are able to register, submit articles, then the editorial board plays a role in the process of managing OJS on a regular basis and arrangements. Limited time and instruments used during service can be minimized with the enthusiasm of the workshop participants and a family atmosphere to jointly advance ST3B in research publications and service using OJS that already exists in ST3B
PERAN KETELADANAN ORANG TUA KRISTEN DALAM PEMBENTUKAN KARAKTER ANAK USIA 6-12 TAHUN DI GEREJA BETHEL TABGHA
Authors: Suryady Robertus
Published: November 2023

The reality of a child's development and growth necessitates the assistance and guidance of both parents in providing support and serving as exemplary figures. Parents hold the greatest responsibility in the development of the overall existence of their children, including their physical and psychological needs, to enable them to grow and mature towards a harmonious and mature personality. This study is entitled "The Role of Christian Parental Exemplars in the Formation of Character in Children Aged 6-".Over the span of 12 years in the Bethel Indonesia Tabgha Church, an inquiry has been formulated regarding the role of Christian parental leadership and the formation of character in children between the ages of 6 and 12. The purpose of this study is to discover the principles governing the Christian parental exemplar based on biblical values, as well as to investigate the formation of the characters of 6-12 year-old children in the Bethel Indonesia Tabgha Church.This research employed a qualitative approach utilizing literature review and descriptive methods for data collection through interviews, observations, and documentations of six participants.Based on the analysis of the data conducted, the conclusion was drawn that Christian parents play a significant role in shaping the character of children aged 6-12 years old. In shaping the character of a child, Christian parents must comprehend the various types of exemplary roles and character-forming approaches for children aged 6 to 12.
Review on Carbon-Graphene Nanocomposite based conductive-ink in printed electronics
Authors: Dave Pranav , Rajani Altaf
Published: November 2023

Energy is the divesting need of human being to make the life easy going and comfortable. But according to the recent scenario, there will be insufficient source of generating energy. Printed electronics is a new concept of printing technology. PE is safest printing ink technology for securing documentation, for making circuits on different subtracts, less time consuming for making and easily detect if counterfeit. Nanoprint technology with semiconductor materials is in improvising and it has been future trend in energy sector with enhancing various properties of nanomaterials. It has been developed in the area of the digital printing technology by using and combining different nanomaterials. With ever-increasing demand for light-weight, small, and transportable devices, the speed of production of electronic and optoelectronic devices is consistently increasing, and alternatives to the current vital, voluminous, fragile, semi semiconducting and clear materials will inevitably be needed at intervals the long run. This review article explains about the carbon-Graphene nanocomposite based conductive ink, which can be a source in digital printing technology to draw various types of circuits and to make different surface to conductive surfaces. It also describes brief information about carbon and Graphene material individually. It also concludes carbon-graphene nanocomposite based conductive ink in printed electronics technology with several literature surveys.
Review of Bioinformatics Tools and Techniques to Accelerate Ovarian Cancer Research
Authors: Beg Anam , Parveen Rafat
Published: November 2023

Since the history of humans there was no definitive cure for cancer. The rapid development in the field of bioinformatics has resulted in acceleration of advancement of cancer research. As computing and IT technology improves over time the use and importance of bioinformatics will also rise. The bulk of biological data created by biomedical researchers has increased over the years, and it has become difficult to store and analyze that data. Faster computer processors and advancement in quantum computing will solve the conventional problem of slow data processing and will make the use of bioinformatics even attractive for scientists and researchers across the globe. The success of potential drug candidates and vaccines were identified and credit goes to bioinformatics gene simulation sequencing, simulation and fast data processing. The results were development of a vaccine in record time all thanks to bioinformatics approaches. This paper explores the contribution that bioinformatics has been able to make in the field of ovarian cancer and how the use of DNA sequencing and simulation helped in developing targeted drugs such as PARP inhibitors. It also elucidates the impact bioinformatics can make in developing effective therapies in times to come. Genome sequencing has paved the way in understanding the disease, possible treatment options analyze mutations and further predict the drug target. In this review we will highlight different aspects of bioinformatics tools and techniques that have accelerated the ovarian cancer research.
3D Multimodal Brain Tumor Segmentation and Grading Scheme based on Machine, Deep, and Transfer Learning Approaches
Authors: Tasci Erdal , Ugur Aybars , Camphausen Kevin , Zhuge Ying , Zhao Rachel , Krauze Andra
Published: November 2023

Glioma is one of the most common tumors of the brain. The detection and grading of glioma at an early stage is very critical for increasing the survival rate of the patients. Computer-aided detection (CADe) and computer-aided diagnosis (CADx) systems are essential and important tools that provide more accurate and systematic results to speed up the decision-making process of clinicians. In this paper, we introduce a method consisting of the variations of the machine, deep, and transfer learning approaches for the effective brain tumor (i.e., glioma) segmentation and grading on the multimodal brain tumor segmentation (BRATS) 2020 dataset. We apply popular and efficient 3D U-Net architecture for the brain tumor segmentation phase. We also utilize 23 different combinations of deep feature sets and machine learning/fine-tuned deep learning CNN models based on Xception, IncResNetv2, and EfficientNet by using 4 different feature sets and 6 learning models for the tumor grading phase. The experimental results demonstrate that the proposed method achieves 99.5% accuracy rate for slice-based tumor grading on BraTS 2020 dataset. Moreover, our method is found to have competitive performance with similar recent works.
From computerisation to digital transformation: the relationship between concepts
Authors: Churikova Anna Yur'evna
Published: November 2023

Background: information technologies and systems have become an integral part of society. State and municipal authorities are forced to adapt to the digital reality. One important part of this process is establishing a clear and logical terminological base. However, at present there are no normative definitions of commonly used terms related to the processes of implementation and use of information technologies. Objective: to analyze the concepts of computerization, informatization, automation, digitalization and digital transformation of state and municipal government, to draw a relationship between these concepts and give their definition. Methodology: general analysis, formal logic method, comparative analysis, as well as system-structural method. Results and conclusions: it was concluded that the terms computerization, informatization, automation, digitalization and digital transformation have different meanings and actually reflect various aspects of the process of introduction and dissemination of information and telecommunication technologies into the life of society and the state, while they are closely related to each other and in fact are carried out simultaneously. Based on the analysis of scientific literature and current legislation, a comprehensive categorical and terminological apparatus of processes associated with the introduction and use of information technologies and systems in the activities of state and municipal authorities is proposed. The proposed formulations help establish terminological clarity and certainty and can be used in regulations and further scientific research.
Reflection of the images of the Macedon kings Philip and Alexander in current school textbooks on universal history
Authors: Aleksandrova Olga
Published: November 2023

The subject of research is the images of famous figures of the antiquity era – the King of Macedonia Philip II and his son Alexander, and their reflection on the pages of textbooks on universal history for the 5th grade of the school. Particular attention is paid to the correspondence of the information contained in school textbooks to historical sources and materials of historical research on these rulers. The completeness of the reflection of the images of the two most famous Macedonian kings is analyzed, as well as a system of tasks and questions that allow to deepen knowledge both directly about outstanding historical figures and about the turning period of ancient history as a whole. The authors come to the conclusion that the personality and activity of Philip is almost completely eclipsed by the vivid image of Alexander, which corresponds to general historiographical trends. Philip's era transformations, which changed the course of not only Greek, but also world history, are briefly and casually discussed, or only one of the sides of his detelnost (military reform) is considered. This does not allow us to fully assess the significance of this figure for Ancient history, to analyze his contribution to the transformation of the Greek world. At the same time, Alexander is presented in textbooks not just as a talented commander, but, in fact, as the greatest hero of antiquity. All the negative aspects of his personality have been smoothed out, they are practically not mentioned, in the end there remains a brilliant commander and a talented ruler. It seems that this can lead not only to a distorted perception of the activities of specific historical figures, but also to the formation of an inherently vicious belief that timely reforms and transformations are of incomparably less value than military campaigns and conquests.
N-WASP-dependent branched actin polymerization attenuates B-cell receptor signaling by increasing the molecular density of receptor clusters
Authors: Bhanja Anshuman , Seeley-Fallen Margaret K. , Lazzaro Michelle , Upadhyaya Arpita , Song Wenxia
Published: November 2023

Antigen-induced B-cell receptor (BCR) signaling is critical for initiating and regulating B-cell activation. The actin cytoskeleton plays essential roles in BCR signaling. Upon encountering cell-surface antigens, actin-driven B-cell spreading amplifies signaling, while B-cell contraction following spreading leads to signal attenuation. However, the mechanism by which actin dynamics switch BCR signaling from amplification to attenuation is unknown. Here, we show that Arp2/3-mediated branched actin polymerization is required for B-cell contraction. Contracting B-cells generate centripetally moving actin foci from lamellipodial F-actin networks in the B-cell plasma membrane region contacting antigen-presenting surfaces. Actin polymerization driven by N-WASP, but not WASP, initiates these actin foci and facilitates non-muscle myosin II recruitment to the contact zone, creating actomyosin ring-like structures. Furthermore, B-cell contraction increases BCR molecular density in individual clusters, leading to decreased BCR phosphorylation. Increased BCR molecular density reduced levels of the stimulatory kinase Syk, the inhibitory phosphatase SHIP-1, and their phosphorylated forms in individual BCR clusters. These results suggest that N-WASP-activated Arp2/3, coordinating with myosin, generates centripetally moving foci and contractile actomyosin ring-like structures from lamellipodial networks, enabling contraction. B-cell contraction attenuates BCR signaling by pushing out both stimulatory kinases and inhibitory phosphatases from BCR clusters, providing novel insights into actin-facilitated signal attenuation.
Recognition and Cleavage of Human tRNA Methyltransferase TRMT1 by the SARS-CoV-2 Main Protease
Authors: D′Oliviera Angel , Dai Xuhang , Mottaghinia Saba , Geissler Evan P. , Etienne Lucie , Zhang Yingkai , Mugridge Jeffrey S.
Published: November 2023

The SARS-CoV-2 main protease (M
pro
) is critical for the production of functional viral proteins during infection and, like many viral proteases, can also target host proteins to subvert their cellular functions. Here, we show that the human tRNA methyltransferase TRMT1 can be recognized and cleaved by SARS-CoV-2 M
pro
. TRMT1 installs the N2,N2-dimethylguanosine (m2,2G) modification on mammalian tRNAs, which promotes global protein synthesis and cellular redox homeostasis. We find that M
pro
can cleave endogenous TRMT1 in human cell lysate, resulting in removal of the TRMT1 zinc finger domain required for tRNA modification activity in cells. Evolutionary analysis shows that the TRMT1 cleavage site is highly conserved in mammals, except in Muroidea, where TRMT1 may be resistant to cleavage. In primates, regions outside the cleavage site with rapid evolution could indicate adaptation to ancient viral pathogens. We determined the structure of a TRMT1 peptide in complex with M
pro
, revealing a substrate binding conformation distinct from the majority of available M
pro
-peptide complexes. Kinetic parameters for peptide cleavage showed that the TRMT1(526-536) sequence is cleaved with comparable efficiency to the M
pro
-targeted nsp8/9 viral cleavage site. Mutagenesis studies and molecular dynamics simulations together indicate that kinetic discrimination occurs during a later step of M
pro
-mediated proteolysis that follows substrate binding. Our results provide new information about the structural basis for M
pro
substrate recognition and cleavage that could help inform future therapeutic design and raise the possibility that proteolysis of human TRMT1 during SARS-CoV-2 infection suppresses protein translation and oxidative stress response to impact viral pathogenesis.Viral proteases can strategically target human proteins to manipulate host biochemistry during infection. Here, we show that the SARS-CoV-2 main protease (M
pro
) can specifically recognize and cleave the human tRNA methyltransferase enzyme TRMT1, which installs a modification on human tRNAs that is critical for protein translation. Our structural and functional analysis of the M
pro
-TRMT1 interaction shows how the flexible M
pro
active site engages a conserved sequence in TRMT1 in an uncommon binding mode to catalyze its cleavage and inactivation. These studies provide new insights into substrate recognition by SARS-CoV-2 M
pro
that could inform future antiviral therapeutic design and suggest that proteolysis of TRMT1 during SARS-CoV-2 infection may disrupt tRNA modification and host translation to impact COVID-19 pathogenesis or phenotypes.
Comparison of feeding preferences of herbivorous fishes and the sea urchin Diadema antillarum in Little Cayman
Authors: Spiers Lindsay , Frazer Thomas K.
Published: November 2023

On Caribbean coral reefs, losses of two key groups of grazers, herbivorous fishes and Diadema antillarum, coincided with dramatic increases in macroalgae, which have contributed to decreases in the resilience of these coral reefs and continued low coral cover. In some locations, herbivorous reef fishes and D. antillarum populations have begun to recover, and reductions in macroalgal cover and abundance have followed. Harder to determine, and perhaps more important, are the combined grazing effects of herbivorous fishes and D. antillarum on the structure of macroalgal communities. Surprisingly few studies have examined the feeding preferences of D. antillarum for different macroalgal species, and there have been even fewer comparative studies between these different herbivore types. Accordingly, a series of in-situ and ex-situ feeding assays involving herbivorous fishes and D. antillarum were used to examine feeding preferences. Ten macrophytes representing palatable and chemically and/or structurally defended species were used in these assays, including nine macroalgae, and one seagrass. All species were eaten by at least one of the herbivores tested, although consumption varied greatly. All herbivores consumed significant portions of two red algae species while avoiding Halimeda tuna, which has both chemical and structural defenses. Herbivorous fishes mostly avoided chemically defended species while D. antillarum consumed less of the structurally defended algae. These results suggest complementarity and redundancy in feeding by these different types of herbivores indicating the most effective macroalgal control and subsequent restoration of degraded coral reefs may depend on the recovery of both herbivorous fishes and D. antillarum.
Seq2science: an end-to-end workflow for functional genomics analysis
Authors: van der Sande Maarten , Frölich Siebren , Schäfers Tilman , Smits Jos G.A. , Snabel Rebecca R. , Rinzema Sybren , van Heeringen Simon J.
Published: November 2023

Sequencing databases contain enormous amounts of functional genomics data, making them an extensive resource for genome-scale analysis. Reanalyzing publicly available data, and integrating it with new, project-specific data sets, can be invaluable. With current technologies, genomic experiments have become feasible for virtually any species of interest. However, using and integrating this data comes with its challenges, such as standardized and reproducible analysis. Seq2science is a multi-purpose workflow that covers preprocessing, quality control, visualization, and analysis of functional genomics sequencing data. It facilitates the downloading of sequencing data from all major databases, including NCBI SRA, EBI ENA, DDBJ, GSA, and ENCODE. Furthermore, it automates the retrieval of any genome assembly available from Ensembl, NCBI, and UCSC. It has been tested on a variety of species, and includes diverse workflows such as ATAC-, RNA-, and ChIP-seq. It consists of both generic as well as advanced steps, such as differential gene expression or peak accessibility analysis and differential motif analysis. Seq2science is built on the Snakemake workflow language and thus can be run on a range of computing infrastructures. It is available at https://github.com/vanheeringen-lab/seq2science.
Gender equality in Bamenda universities: a case study
Authors: Sucuoğlu Esen , Nkudong Roland
Published: November 2023

A crucial issue is the representation of women in leadership roles in education, especially in higher education. The administrations of Cameroon are aiming to advance gender equality in the country's educational system as well as in other areas like economy, social issues, and the workplace. The purpose of this study is to look at the variables affecting gender equality at the University of Bamenda. The idea of how the staff at the University of Bamenda see gender equality was investigated to achieve the goal. A qualitative approach was taken in conducting the study. Google meet platform was used to collect data for this study via semi-structured interview questions in groups 4 staff. Two portions made up this: Section B has five semi-structured interview questions while Section A has five demographic questions. The study included 20 participants from the ENS at the University of Bamenda. The distribution of the Google meet link was through WhatsApp group, and the qualitative method was used to examine the data gathered. The information exposed some of the difficulties the participants have had with respect to equitable compensation, advancement chances, and research opportunities. Women are underrepresented in management and lecturing roles, according to the data. This can be linked to a lack of tangible official legislation intended to advance gender equality, a lack of effective communication channels, and cultural factors. However, in accordance with government policy, the university strives to achieve gender equality throughout all departments.
Did the Euro Really Increase Corruption in the Eurozone? A Counterfactual Analysis
Authors:   University of Murcia, Beyaert Arielle , López-Gómez Laura ,   University of Murcia, García-Solanes Jose ,   University of Murcia
Published: November 2023

In this paper we apply the Synthetic Control Method developed by Abadie, Diamond and Hainmüeller (2010) to assess the extent to which the adoption of the euro has affected corruption in three groups of Eurozone countries: the core, southern and eastern countries. To do so, we construct counterfactuals for each group and for individual countries and compare them with the actual evolution of the corruption-control indicator. Except in the case of the Netherlands, where significant negative effects are detected, we find evidence that the adoption of the euro has either contributed to reducing corruption or has not affected it significantly.
Real Estate in a Post-Pandemic World: How Can Policies Make Housing More Enviromentally Sustainable and Affordable?
Authors:   OECD, Melo Luiz de
Published: November 2023

The real estate sector, including the residential and commercial market segments, is a heavy consumer of energy and, as a result, a sizeable source of emissions of greenhouse gases. This is primarily on account of the consumption of energy in heating and cooling systems, as well as in the use of domestic appliances. The construction, maintenance and thermal characteristics of buildings add to the sector’s energy consumption. Based on a review of scholarly and policy-focused work, this paper argues that decarbonisation strategies to meet agreed climate change targets will need to incorporate policies targeted to the specificities of the real estate sector. They include addressing split incentives among owner-occupiers, landlords and renters (in the private and social housing markets) for investment in home improvements and energy retrofitting; raising the standards of energy performance for new and existing properties through labelling/certification and other means; and reducing the cost of finance for needed investments while broadening access to the underserved population.
Abundance and Diversity of Leaf Litter and Subsoil Arthropods in Four Different Sites of Three Agroecological Zones of Northwest Part of Bangladesh
Authors: Mahdi Shah H. A. , Sarker Asia , Uddin Md. Nasir , Mahfuz Istiak , Rahim Md. Abdur
Published: November 2023

Leaf litter and subsoil arthropods are biotic factors of an ecosystem that play a significant role in nutrient cycling between soil and vegetation. The present study aimed to explore the abundance and diversity of leaf litter and subsoil arthropods in four different sites of three agroecological zones of the Northwest part of Bangladesh. A total of 1920 individuals belonging to 17 orders, 28 families and 34 species were found in the present study where 1099 individuals (14 orders, 23 families, 28 species) from Rajshahi University Campus (Site A), 259 individuals (6 orders, 7 families, 8 species) from Rajshahi Fruit Research Center (Site B), 354 individuals (7orders, 13 families, 13 species) from Kakon Hat Municipality (Site C) and 208 individuals (5 orders, 10 families, 10 species) from Chalan Beel (Site D) were collected during the period from November 2021 to October 2022. In this study, within the three agroecological zones, the highest number of individuals was recorded in Site A (n=1099, 57.24%) and the lowest number in Site D (n=208, 10.83%). Among 17 orders Coleoptera (624, 32.50%) was the first dominant order, Hymenoptera (414, 21.56%) was the second largest order, followed by Araneae (202, 10.52%) and the least dominant order was Metastigmata (8, 0.42%). Formicidae was the most dominant family among collected 28 families, sharing 376 individuals of the total captured individuals and Staphylinidae, sharing 198 individuals, was the second largest family, whereas Tenebrionidae (n=8), Psychodidae (n=8), and Laelapidae (n=8) were the minor dominant families in this study. Among the total of 34 species, Lasioderma sp. was the most dominant species, sharing 189 individuals with 9.84% of the total collected individuals whereas Alphitobius sp., Psychoda sp., and Hypoaspis sp. were least dominant species, and each species of these three comprised of only 8 members. In this study, 15 species were very common, 5 were common, 7 were fairly common, and 7 were rare. The values of Shannon diversity index (H'), Simpson’s diversity index (I-D), Margalef diversity index (DMg), Menhinick Richness index (DMn), Berger Parker dominance index (d) and Pielou’s evenness index (J') were 3.22, 0.95, 4.37, 0.78, 0.10, respectively. The study was the first attempt to examine the abundance and diversity of leaf litter and subsoil arthropods in four different sites of three agroecological zones in the northwest part of Bangladesh. Further study may be necessary for molecular identification of these species.
Pattern of Vegetable Consumption among Pregnant Women Attending Primary Health Care Facilities in Patani Local Government Area of Delta State, Nigeria
Authors: Okogba Lilian E. , Moyegbone John E. , Adjene Josiah O.
Published: November 2023

Aim: Vegetables provide key nutrients essential to promoting and maintaining good health. This study aimed to determine the perception of the importance and pattern of vegetable consumption among pregnant women attending Primary Health Care facilities in Patani Local Government Area (L.G.A) of Delta State, Nigeria.

Study Design:  A population-based descriptive cross-sectional survey of 368 pregnant women aged 15-49 years was conducted in Patani L.G.A, Plateau State, Nigeria using a multi-stage cluster random sampling design.

Methodology: Data were collected by face-to-face interview using a structured questionnaire. Food Frequency Questionnaire (FFQ) data were used to estimate habitual frequency of intake of dark green leafy vegetable for previous 7 days.

Results: Of the 368 pregnant women, age group 21-25 years and 26-30 years with prevalence of 95 (25.8%) and 90 (24.5%) respectively were the highest age groups. Two hundred and twenty-one (60.1%) agree that a maternal diet rich in vegetables and eaten during pregnancy reduces risk of gestational diabetes, hypertension, preterm birth and foetal growth restriction, and the perception of the respondents was high. Ugu leaf 257 (69.8%), Bitter leaf 173 (47.0%) and water leaf 151 (41.0%) were the most available vegetable in the respondent’s community. 19% of the respondents did not consume vegetable, 26.6% consumed vegetable seven times and 13.9% consumed vegetables three times in the last 7 days prior to the study. The mean frequency of vegetable consumption is 11.6%. 55% of respondents put vegetables into food towards the end of cooking the food. 33.4% of the respondents spent N 150- N 200 to purchase vegetable to cook.

Conclusion: Vegetable consumption is highly nutritious especially during pregnancy. Its pattern of consumption varies depending on the perception of its importance, educational status, age group, types of vegetable available and the financial power of purchase.
Evaluating the Effects of Sclerotinia Rot Resistant Genotypes on Different Indian Mustard Traits and Yield Using Generation Analysis
Authors: Singh Manjeet , Avtar Ram , Kumar Neeraj , Ghanghas Manjeet Singh , Redhu Neeru , Loyal Atul , Dhillon Ankit , Redhu Mandeep
Published: November 2023

Sclerotinia stem rot caused by the pathogen Sclerotinia sclerotiorum is a serious threat to Indian mustard cultivation and causes up to 90% loss in seed yield. The present investigation was conducted to understand the inheritance pattern of Sclerotinia stem rot resistance through generation mean analysis, as a first step in addressing the problem. Six generations i.e.., P1, P2, F1, F2, BC1P1 and BC1P2 of a cross between a sclerotinia stem rot resistant genotype viz., RH 1222-28 and two susceptible genotypes viz., EC 766300 and EC 766123 were evaluated for sclerotinia stem rot resistance, yield and its component traits at timely sown conditions. For resistance assessment, plants were artificially inoculated with 5 days-old pure culture of S. Sclerotiorum at the post-flowering stage and stem lesion length was measured (cm) from each inoculated stem at 20 days after inoculation. Sclerotinia stem rot resistance, seed yield, and their component traits were adequately explained by the epistatic interaction model. Furthermore, additive, dominance, and epistatic gene effects were implicated in the expression of resistance, yield, and traits associated with it. In order to generate Indian mustard cultivars with high yielding potential and resistant to sclerotinia stem rot, reciprocal recurrent selection would be the most successful method.