bluuebunny/crossref_metadata_2025 huggingface dataset:
Cr(VI) anion-imprinted polymer synthesized on mesoporous silicon via synergistic action of bifunctional monomers for precise identification and separation of Cr(VI) from aqueous solution by fixed-bed adsorption
Authors: Su Ya , Kang Yumeng , Huang Qinya , Zhang Jiahao , Liu Jinhua , Hu Zhaoyong , Liu Zhanchao , Liu Yan
Published: April 2023

The novel Cr(VI) anion-imprinted polymer (Cr(VI)-IIP) was prepared by a surface imprinting technique with bifunctional monomers pre-assembly system based on mesoporous silicon (SBA-15). The synthesized Cr(VI)-IIP was characterized by Fourier transmission infrared spectra (FT-IR), energy dispersive spectrometer (EDS), scanning electron microscope (SEM), transmission electron microscope (TEM), X-ray powder diffractometer, N2 adsorption–desorption and thermogravimetric analysis (TGA), proving to be with a highly ordered mesoporous structure, as well as favorable thermal stability. The saturated adsorption amount was 96.32 mg/g, which was 2.7 times higher than that of non-imprinted polymer (NIP). Kinetic experiments showed that the adsorption equilibrium state was obtained within 70 min. In addition, in the selectivity experiments, Cr(VI)-IIP exhibited strong specific recognition ability for Cr(VI) and could realize the separation of Cr(VI) and Cr(III) from an aqueous solution. The dynamic adsorption experiments exhibited that the dynamic adsorption efficiency of Cr(VI)-IIP was as high as 71.57%. Meanwhile, the dynamic regeneration experiments showed that the adsorption amount of Cr(VI)-IIP did not decrease significantly after repeating for five times. All of the findings suggested that Cr(VI)-IIP could achieve precise identification as well as efficient separation of Cr(VI) from aqueous solution.
Proektirovanie tsifrovoi obrazovatel'noi sredy dlia professional'nogo razvitiia pedagoga
Authors: Berezina Arina Aleksandrovna
Published: April 2023

The article discusses services and platforms for online training and professional development of teachers.
Chemical Strategies towards the Development of Effective Anticancer
Peptides
Authors: Li Cuicui , Jin Kang
Published: April 2023

Cancer is increasingly recognized as one of the primary causes of death and
has become a multifaceted global health issue. Modern medical science has made significant
advancements in the diagnosis and therapy of cancer over the past decade. The detrimental
side effects, lack of efficacy, and multidrug resistance of conventional cancer therapies
have created an urgent need for novel anticancer therapeutics or treatments with
low cytotoxicity and drug resistance. The pharmaceutical groups have recognized the crucial
role that peptide therapeutic agents can play in addressing unsatisfied healthcare demands
and how these become great supplements or even preferable alternatives to biological
therapies and small molecules. Anticancer peptides, as a vibrant therapeutic strategy
against various cancer cells, have demonstrated incredible anticancer potential due to
high specificity and selectivity, low toxicity, and the ability to target the surface of traditional
“undruggable” proteins. This review will provide the research progression of anticancer
peptides, mainly focusing on the discovery and modifications along with the optimization
and application of these peptides in clinical practice.
Nobiletin in Cancer Therapy; Mechanisms and Therapy Perspectives
Authors: Moazamiyanfar Reza , Rezaei Sepideh , AliAshrafzadeh Hasan , Rastegar-Pouyani Nima , Jafarzadeh Emad , Mouludi Kave , Khodamoradi Ehsan , Zhaleh Mohsen , Taeb Shahram , Najafi Masoud
Published: April 2023

Cancer has remained to be one of the major challenges in medicine and regarded as the second leading
cause of death worldwide. Different types of cancer may resist anti-cancer drugs following certain mutations
such as those in tumor suppressor genes, exhaustion of the immune system, and overexpression of drug
resistance mediators, which increase the required concentration of anticancer drugs so as to overcome drug resistance.
Moreover, treatment with a high dose of such drugs is highly associated with severe normal tissue toxicity.
Administration of low-toxic agents has long been an intriguing idea to enhance tumor suppression. Naturally
occurring agents e.g., herb-derived molecules have shown a dual effect on normal and malignant cells. On
the one hand, these agents may induce cell death in malignant cells, while on the other hand reduce normal cell
toxicity. Nobiletin, one of the well-known polymethoxyflavones (PMFs), has reportedly shown various beneficial
effects on the suppression of cancer and the protection of normal cells against different toxic agents. Our
review aims to explain the main mechanisms underlying nobiletin as an inhibitor of cancer. We have reviewed
the mechanisms of cancer cell death caused by nobiletin, such as stimulation of reactive oxygen species (ROS),
modulation of immune evasion mechanisms, targeting tumor suppressor genes, and modulation of epigenetic
modulators, among others; the inhibitory mechanisms of nobiletin affecting tumor resistance properties such as
modulation of hypoxia, multidrug resistance, angiogenesis, epithelial-mesenchymal transition (EMT) have been
fully investigated. Also, the inhibition of anti-apoptotic and invasive mechanisms induced by nobiletin will later
be discussed. In the end, protective mechanisms of nobiletin on normal cells/tissue, clinical trial results, and future
perspectives are reviewed.
Psidium guajava: An Insight into Ethnomedicinal Uses, Phytochemistry, and Pharmacology
Authors: Chechani Bhawna , Roat Priyanka , Hada Sonal , Yadav Dinesh Kumar , Kumari Neetu
Published: April 2023

Background:

Psidium guajava (guava) is widely distributed in tropical and subtropical
regions and adapted to various environmental conditions. Guava is an important economic fruit
widely used as food and folk medicine. It contains flavonoids, alkaloids, tannins, triterpenoids, reducing
sugars, essential oils, carotenoids, polyphenols, etc. The presence of triterpenoid acids such
as guavacoumaric, ursolic, jacoumaric, guajavanoic, guavenoic, and Asiatic acids helps to develop
novel drugs against various diseases. It is used traditionally for medicinal purposes, mainly for antioxidant,
antimicrobial, antispasmodic, antidiabetic, anticancer, antiallergy, anti-inflammatory,
and hepato-protective properties.

Objective:

The systematic literature study aims to summarize its botanical description, phytochemicals,
pharmacological activities, and clinical trials. This review focuses on the plant’s chemical
composition and scientific approaches to human welfare.

Methods:

A systematic literature search was done on Psidium guajava through previous literature
and online databases such as Google Scholar, Pubmed, Science Direct, etc., to explain its ethnomedicinal
uses, phytochemistry, and pharmacological applications.

Results:

Previous literature studies of Psidium guajava suggest it can serve as antioxidant, antimicrobial,
antispasmodic, antidiabetic, anticancer, anti-allergy, anti-inflammatory, and hepatoprotective
effects. Successful clinical trials performed on the plant extracts against infantile rotaviral
enteritis and infectious gastroenteritis showed future directions to work with the plant for clinical
applications.

Conclusion:

In this review, an attempt is made to show all literature studied, especially in phytochemistry,
pharmacology, clinical trials and uses as traditional folk medicine around the world.
The leaves have been used by folklore over the years to treat various ailments such as skin ulcers,
diarrhoea, vaginal irritation, cough, conjunctivitis, etc. Further studies are required to explore more
therapeutic remedies and to develop new medicines for future perspectives.
Chemical Strategies Toward Prodrugs and Fluorescent Probes for
Gasotransmitters
Authors: Su Ma , Ji Xingyue , Liu Feng , Li Zhang , Yan Duanyang
Published: April 2023

Three gaseous molecules are widely accepted as important gasotransmitters in mammalian
cells, namely NO, CO and H2S. Due to the pharmacological effects observed in preclinical studies,
these three gasotransmitters represent promising drug candidates for clinical translation. Fluorescent
probes of the gasotransmitters are also in high demand; however, the mechanisms of actions
or the roles played by gasotransmitters under both physiological and pathological conditions remain
to be answered. In order to bring these challenges to the attention of both chemists and biologists
working in this field, we herein summarize the chemical strategies used for the design of both
probes and prodrugs of these three gasotransmitters.
Traditional Chinese Medicine Targeting Sarcoma Virus Oncogene-related Diseases
Authors: Wang Yiying , Wang Xiaoyu , Su Kexin , Yang Yifu
Published: April 2023

The sarcoma virus oncogene (Src) tyrosine kinase, a nonreceptor protein-tyrosine kinase, plays a crucial role in cell survival, migration, differentiation and proliferation. The study of Src has developed considerably since it was first discovered as a proto-oncogene. Src has also been associated with inflammation and bone-related diseases. Src inhibitors (bosutinib, ponatinib, dasatinib, and vandetanib) have been put into clinical use. However, their side effects and cardiovascular toxicity may be a concern. There is an urgent need to explore new Src inhibitors. Traditional Chinese medicine (TCM), which has a vast history, can provide a broad resource base. Many natural compounds and TCM extracts have the potential for anti-Src treatment. This article describes the natural compounds and extracts from TCM.
Current Trends and Future Prospects on the Therapeutic Potential of Cordia dichotoma G. Forst.-A Valuable Folk Medicine
Authors: Tripathi Rati Kailash Prasad
Published: April 2023

Background:

Cordia dichotoma G. Forst (Boraginaceae), usually recognized as Clam-my/Indian cherry, is a familiar Ayurvedic, Unani, and modern herbal medicine used for diverse un-related ailments since antiquity. It is rich in phytochemical constituents, has nutritional significance, and possesses enormous pharmacological properties.

Objective:

This review has been established to highlight the importance of C. dichotoma G. Forst by providing comprehensive knowledge of its phytochemical, ethnobotanical, pharmacological, and toxicological aspects with a perception to foster pharmaceutical research to exploit its maximum po-tential as a therapeutic agent.

Methods:

Literature research has been accomplished using Google Scholar and databases like Sci-ence Direct, WOS, PubMed, SciFinder, Scopus with updates until June 2022.

Results:

The work is an update on C. dichotoma G. and it reviewed and analyzed its phytochemical, ethnobotanical, pharmacological and toxicological knowledge from early human communities to contemporary medicinal and pharmaceutical applications with comprehensive examination of myri-ad plausible applications in the present-day scientific milieu. The species depicted the presence of diverse phytochemical profiles, possibly justifying its bioactive potential.

Conclusion:

This review will help lay grounds to facilitate state-of-art research intended to acquire additional information about the plant. The study offers opportunities to explore bio-guided isola-tion strategies for isolating and purifying phytochemical constituents that are biologically effective including pharmacological and pharmaceutical aspects to better understand its clinical relevance. Exploring pure isolated phytoconstituents for their mode of action including estimation of their bio-availability and pharmacokinetic parameters would be of considerable interest in assessing the at-tained pharmacological effect. Clinical studies are required to validate the suitability of its tradition-al usage.
A Quinquennial Review on Recent Advancements and Developments in
Search of Anti-malarial Agents
Authors: Dhameliya Tejas M. , Kathuria Deepika , Patel Tanvi M. , Dave Bhavarth P. , Chaudhari Amit Z. , Vekariya Drashtiben D.
Published: April 2023

Malaria has been a major parasitic disease in tropical and subtropical regions and is esti-mated to kill between one and two million people (mainly children) every year. Novel anti-malarial agents are urgently needed to combat the malarial parasites enduring resistance to the current medi-cations, leading to increased morbidity and mortality. The heterocycles, holding a prominent posi-tion in chemistry and found in both natural and synthetic sources, have shown several biological ac-tivities including anti-malarial activity. Towards this goal, several research groups have reported the design and development of novel and potential anti-malarial agents like artemisinin, benzimidazole, benzothiazole, chalcone, cyclopeptide, fosmidomycin, furan, indole oxadiazole, 2-oxindoles, perox-ides, pyrazole, pyrazolines, pyridines, pyrimidine, pyrrolidine, quinazoline, quinazolinone, quino-lone, quinoline, thiazole, triazole and other scaffolds acting against newly emerging anti-malarial targets. The present work reports the complete quinquennial coverage of anti-malarial agents re-ported during 2016-2020 with a view of providing the merits and demerits of reported anti-malarial scaffolds, structure-activity relationship, along with their in vitro/ in vivo/ in silico profiles to the medicinal chemists working in the field of design and discovery of novel anti-malarial agents
Advances in Imaging Techniques of the Blood-brain Barrier and Clinical
Application
Authors: Cui Jianing , Bian Wenjin , Wang Jun , Niu Jinliang
Published: May 2023

The blood-brain barrier (BBB) is an important structure that maintains the normal function of the central nervous system (CNS). The functional
structure of BBB is closely related to diseases of CNS, including degenerative diseases, brain tumours, traumatic brain injury, stroke, etc. Imaging
methods were commonly used to monitor the integrity of BBB, such as DCE-MRI, DSC-MRI, and PET, this contributes to understand the process
of related diseases and develop appropriate treatment options. In recent years, many studies had shown that the MRI methods (ASL, IVIM, CEST,
etc.) could evaluate blood-brain barrier function, which use endogenous contrast agents and become an increasingly great concern. Another image
methods (FUS, uWB-eMPs) can open up the normal BBB, allowing macromolecular drugs across the locally opening BBB, which could be
beneficial to the treatment of some brain diseases. In this review, we briefly introduce the theory of BBB imaging modalities and its clinical
application.
Research Progress on the Effect of Autophagy and Exosomes on Liver
Fibrosis
Authors: Du Yikuan , Zhu Silin , Zeng Haojie , Wang Zhenjie , Huang Yixing , Zhou Yuqi , Zhang Weichui , Zhu Jinfeng , Yang Chun
Published: April 2023

Chronic liver disease is a known risk factor for the development of liver cancer, and the development
of microRNA (miRNA) liver therapies has been hampered by the difficulty of delivering miRNA
to damaged tissues. In recent years, numerous studies have shown that hepatic stellate cell (HSC) autophagy
and exosomes play an important role in maintaining liver homeostasis and ameliorating liver fibrosis.
In addition, the interaction between HSC autophagy and exosomes also affects the progression of liver
fibrosis. In this paper, we review the research progress of mesenchymal stem cell-derived exosomes
(MSC-EVs) loaded with specific miRNA and autophagy, and their related signaling pathways in liver
fibrosis, which will provide a more reliable basis for the use of MSC-EVs for therapeutic delivery of
miRNAs targeting the chronic liver disease.
LncRNA FAM83H-AS1 Contributes to the Radio-resistance and Proliferation
in Liver Cancer through Stability FAM83H Protein
Authors: Jiang Xiaocong , Lan Yuhong , Zhang Yingchun , Dong Yuhong , Song Ting
Published: May 2023

Background:

Liver cancer (LC) is one of China's most common malignant tumors,
with a high mortality rate, ranking third leading cause of death after gastric and esophageal cancer.
Recent patents propose the LncRNA FAM83H-AS1 has been verified to perform a crucial role in
the progression of LC. LncRNA FAM83H-AS1 has been verified to perform a crucial role in the
progression of LC. However, the concrete mechanism remains to be pending further investigation

Objective:

This study aimed to explore the embedding mechanism of FAM83H-AS1 molecules in
terms of radio sensitivity of LC and provide potentially effective therapeutic targets for LC therapy.

Methods:

Quantitative real-time PCR (qRT-PCR) was conducted to measure the transcription levels
of genes. Proliferation was determined via CCK8 and colony formation assays. Western blot was
carried out to detect the relative protein expression. A xenograft mouse model was constructed to
investigate the effect of LncRNA FAM83H-AS1 on tumor growth and radio-sensitivity in vivo.

Results:

The levels of lncRNA FAM83H-AS1 were remarkably increased in LC. Knockdown of
FAM83H-AS1 inhibited LC cell proliferation and colony survival fraction. Deletion of FAM83H-AS1
increased the sensitivity of LC cells to 4 Gy of X-ray radiation. In the xenograft model, radiotherapy
combined with FAM83H-AS1 silencing significantly reduced tumor volume and weight. Overexpression
of FAM83H reversed the effects of FAM83H-AS1 deletion on proliferation and colony survival
fraction in LC cells. Moreover, the over-expressing of FAM83H also restored the tumor volume
and weight reduction caused by the knockdown of FAM83H-AS1 or radiation in the xenograft model.

Conclusion:

Knockdown of lncRNA FAM83H-AS1 inhibited LC growth and enhanced radiosensitivity
in LC. It has the potential to be a promising target for LC therapy.

Clinical Trial Registration No:

.: ChiCTR1800019378.
Recent Patents of Micro-arc Oxidation Technology
Authors: Yuan Mengchen , Li Zhaolong
Published: May 2023

Micro-arc oxidation (MAO) is a new surface treatment technology that can improve
wear resistance, corrosion resistance, high voltage insulation, and other metal properties. Therefore,
this technology is widely used in automobile manufacturing, aerospace, ship anti-corrosion,
medical equipment, sewage treatment, and other fields. This paper reviews the representative patents
of micro-arc oxidation technology at home and abroad. The micro-arc oxidation processing
device, the process method of micro-arc oxidation processing, the power supply and electrical
parameters of micro-arc oxidation, the preparation of electrolytes, and the methods of anticorrosion
and protection of metal surface are analyzed. The development trend of micro-arc oxidation
technology in the future is discussed. Micro-arc oxidation is a simple, green, and environment-
friendly surface treatment technology, and there will be more patents in the field of micro-
arc oxidation in the future.
effectiveness of flipped classroom model in enhancing Saudi EFL learners' English pronunciation
Authors: Alzahrani Saeed Ahmed , Alqurashi Hassan Saleem
Published: May 2023

This research investigated the Flipped Classroom Model (FCM) in enhancing Saudi EFL learners' English pronunciation. The explanatory sequential design with data collection occurring in two phases was used. The first phase includes a pre-test andapost-test of oral pronunciation, while the second phase includes a focus group interview with the students. The research population included all third-grade high school students in Jeddah who study in the boys' high schools affiliated to the Ministry of Education. Furthermore, the sample included all EFL learners at Ibn Hajer Al-Asqalani high school; 62 students who were divided into two groups: a control group and an experimental group, with the same number of participants. The results reflected the effectiveness of the FCM in enhancing Saudi EFL learners' English pronunciation. Moreover, it was found that the FCM increased learners' motivation, autonomy, and provided learning flexibility. The researcher recommended encouraging teachers to use the FCM to teach Saudi EFL learners' English pronunciation.
Mechanical Complications Following Central Venous Catheterisation in A Tertiary Care Teaching Institute: A Prospective Observational Study
Authors: Mowar Ashita , Singh Vishwadeep , Pahade Akhilesh
Published: May 2023

Background: Central venous catheters are an indispensablecomponent of current day critical care and are employedfor various indications. Central venous catheterizations(landmark-based or ultrasound-guided) are associated withmechanical complications. This study aimed to assess, analyzeand compare the complication rate between two commonlyemployed catheterization routes: Internal jugular vein andsubclavian vein.Methodology: A prospective, observational study comparingtwo landmark-based central venous catheterization techniqueswas planned in a tertiary care teaching institute. 100 patientsrequiring central venous catheterizations were enrolledalternately into the IJV and Subclavian groups. Standardlandmark-based insertion techniques were employed understrict asepsis. All patients were observed for mechanicalcomplications in the first 24 hours following catheterization.Statistical analysis was done using the statistical packageSPSS 20.0. Data were expressed as either mean and standarddeviation or numbers and percentages. Categorical variableswere analyzed using proportions and percentages. Associationbetween categorical variables was established by Chi-squareand odds ratio (OR) with 95% confidence intervals (CI).Results: There were 22 complications observed. Incidence ofcomplications was higher in the IJV group with 17 complicationsversus 5 in Subclavian group. There were 4 major complicationsand 18 minor complications between the two groups. Majorcomplications comprised of hematoma formation (7/22) andarterial puncture (8/22). Incidence of complication was alsoanalyzed with regards to independent variables.Conclusion: Mechanical complications following centralvenous catheterizations was found in both groups studied.Internal jugular venous group had a higher mechanicalcomplication rate than the subclavian group. Ultrasoundguidance and greater detail in delineating the anatomy arelikely to reduce the complication rates.
Spectrum of Endobronchial Ultrasound-guided Transbronchial Needle Aspiration (EBUS-TBNA) in the Diagnosis of Mediastinal Lymphadenopathy: An Experience at Tertiary Care Center
Authors: Johri Nidhi , Kumari Shubhra , Agrawal Tanu , Gupta Aastha
Published: May 2023

Introduction: Endobronchial Ultrasound-guided TransbronchialNeedle Aspiration (EBUS TBNA) is a new minimally invasivetechnique presently used for evaluating mediastinal lesions. Ithas also proved to be valuable for the lymphnode (LN) stagingof lung cancer,as well as for the primary diagnosis of unclearmediastinal lesionsMaterial and Methods: EBUS-FNAs from mediastinal lymphnodes were retrospectively reviewed from January 2020 toJanuary 2022 and their findings were correlated with thehistology.Results: A total of 60 cases were obtained. Out of which, 3cases were non diagnostic, and 57 cases were diagnostic.Three cases were reactive hyperplasia, seventeen weregranulomatous lymphadenitis and thirty-seven cases werepositive for malignant cells. Out of the thirty-seven positivecases for malignant cells, a biopsy was received in 29 of themand 27 cases showed positive histological correlation.Conclusion: EBUS-FNA is a rapid, safe, and effective methodthat can be used routinely to diagnose mediastinal lesions.
Comparison of Hippocampal Sparing Intensity Modulated Radiotherapy Plans in Patients of Brain Tumors treated by Three-dimensional Conformal Radiotherapy
Authors: Chaturvedi Diksha , Kumar Piyush , Chauhan Arvind K. , Kumar Pavan , Nigam Jitendra , Sivaji Silambarasan N. , Silambarasan Navitha
Published: May 2023

Introduction: Radiotherapy plays a key role in brain tumorsafter surgery. However, concerns regarding neurocognitivetoxicity after radiotherapy are being raised. Newer radiotherapytechniques can deliver radiotherapy with better precisionplanning and delivery. Effective hippocampal sparing is possiblewith IMRT which governs the neurocognitive functions. Thepresent study is done to compare whether hippocampal sparingis possible in brain tumors by 3D Conformal Radiotherapyand Intensity Modulated Radiotherapy and their effects onneurocognitive functions.Materials and Methods: Twenty-two patients with brain cancerwere recruited from November 2019 to April 2021. Patients weretreated with 3D-CRT technique and alternate IMRT plans weregenerated. Dosimetric parameters of PTV, organs at risk alongwith hippocampus were evaluated and compared for 3DCRTand IMRT plans. Neurocognitive functions were evaluatedusing MMSE score.Result: In study group, there were 16 males and 6 females withmedian age 45 years. Brain tumors were commonly located infrontal lobe (36%) followed by parieto-occipital lobe (18%) andfronto-temporo-parietal lobe (13.63%). PTV parameters werebetter for IMRT and statistically significant. The OARs did notshow significant difference except in both lens though they arewithin tolerance limits. There is no significant difference in thedosimetric parameters of hippocampus in 3D-CRT and IMRTplans. The p-value for Dmax is 0.79, Dmean is 0.26, Dmin is0.18 between hippocampal sparing radiotherapy plans.Conclusion: Anatomic location of tumor plays a key role indeciding hippocampal sparing. Patients whose NCFs showedimprovement on subsequent visits, highlights the fact thatprimary tumor control is a key factor in deciding decline orimprovement in NCFs. It should be beneficial for LGG that havebetter survival and prognosis as compared to HGG cases.
ANNE BABALARIN OKUL ÖNCESİ DÖNEMDE ÇOCUKLARIN RİSKLİ OYUNLARINA İZİN VERMELERİ İLE ÇOCUKLARIN PROBLEM DAVRANIŞLARI VE SOSYAL BECERİLERİ ARASINDAKİ İLİŞKİNİN İNCELENMESİ
Authors: Bora Ümmü Gül , Kılıç Şükran
Published: April 2023

Okul öncesi dönemdeki çocuklarının birden fazla gelişim alanına katkı sağlayan oyun türlerinden biri riskli oyundur. Uluslararası alan yazında riskli oyun konusunda yapılan araştırmaların olduğu anlaşılmaktadır. Ancak Türkiye’de bu alandaki araştırmaların sınırlı sayıda olduğu görülmüştür. Bu araştırma, riskli oyun alanındaki çalışmalara katkı sağlayabilmesi açısından ve anne babaların riskli oyunlara izin verme düzeylerinin çocuklarının sosyal beceri ve problem davranışları ile ilişkisinin yordanabilmesi açısından önemlidir. Bu bağlamda araştırmanın amacı, okul öncesi eğitime devam eden çocukların anne babalarının riskli oyunlara izin verme düzeylerinin çocukların sosyal becerilerini ve problem davranışlarını yordayıp yordamadığının incelenmesidir. İlişkisel tarama modelinin kullanıldığı bu araştırmanın çalışma grubunu, İstanbul ili Sultangazi ilçesinde bulunan devlete bağlı bağımsız anaokulları ve ilkokula bağlı anasınıflarında okul öncesinde öğrenim gören 48-66 aylık normal gelişim gösteren 253 okul öncesi dönemdeki çocuklarının ve çocukların anne babaları oluşturmaktadır. Araştırma kapsamında veri toplama aracı olarak; Riskli Oyunlara İzin Verme Ölçeği ve Anasınıfı ve Anaokulu Davranış Ölçeğinin iki alt ölçeği olan Sosyal Beceri Ölçeği ve Problem Davranış Ölçeği kullanılmıştır. Araştırmadan elde edilen bulgulara göre; çocukların sosyal becerilerinin ve problem davranışlarının anne babaların riskli oyunlara izin verme düzeylerini yordadığı ve anne babaların riskli oyunlara izin verme düzeyleri ile sosyal beceri arasında pozitif, problem davranış ile arasında negatif bir ilişki olduğu sonucuna ulaşılmıştır.
Faktor-faktor yang Mempengaruhi Ketidaketisan Penggunaan Komputer oleh Pengguna di UMKM Kabupaten Sleman
Authors: Ningrum Widya Stia , Hidayah Nila
Published: May 2023

Komputer telah banyak membawa kemudahan salah satunya memaksimalkan hasil pekerjaan. Semakin berkembangnya teknologi, semakin sulit untuk mengukur apa yang salah dan benar dalam penggunaannya. Di dalam dunia bisnis, kebijakan dan pelatihan sumber daya manusia dikembangkan demi terciptanya kesadaran tentang etika dan penggunaan komputer sebagaimana mestinya. Tujuan dari penelitian ini adalah untuk mengetahui sejauh mana penggunaan komputer yang tidak etis oleh pengguna teknologi informasi di UMKM Kabupaten Sleman. Pada penelitian ini menggunakan metode survei yang merupakan cara untuk mengumpulkan informasi secara luas dari beberapa subjek yang berkaitan. Hasil dari penelitian ini menunjukkan bahwa etika kerja Islam berpengaruh positif terhadap etika penggunaan komputer. Etika penggunaan komputer tidak berpengaruh terhadap ketidaketisan penggunaan komputer. Sedangkan jenis kelamin sebagai faktor moderasi berpengaruh terhadap ketidaketisan penggunaan komputer. Begitu juga pengalaman kerja sebagai faktor moderasi berpengaruh terhadap ketidaketisan penggunaan komputer. Lalu usia sebagai faktor moderasi berpengaruh terhadap ketidaketisan penggunaan komputer. Demikian pula tingkat pendidikan berpengaruh terhadap ketidaketisan penggunaan komputer.
Studi Kelayakan Bisnis Pendirian Bank Pembiayaan Rakyat Syariah (BPRS) di Kalimantan Timur
Authors: Mainata Dedy , Pratiwi Angrum
Published: May 2023

The economy of East Kalimantan as a whole is growing rapidly, however, this was not accompanied by the development of a Sharia Rural Bank (BPRS). This study aims to determine the feasibility of establishing a BPRS in East Kalimantan in terms of financial, marketing, social, economic, and cultural aspects as well as to find out which municipalities are feasible to establish BPRS. This type of descriptive qualitative research, the sample used in Balikpapan and Samarinda, the data collection techniques used observation and interviews. The results showed that the financial aspects of the BPRS were feasible to establish. NPV and IRR calculations show that the investment in the establishment of the BPRS is feasible. The market aspect looks at the potential of GRDP, population and purchasing power. The marketing aspect sees the potential growth of SMEs, business fields and the number of SMEs. Market segmentation and the target market for BPRS are SMEs engaged in trade and culinary. The economic aspect has an impact on regional income, the ease in providing cheap funds for SMEs, opens up community jobs. The social and cultural impact of the community being educated about banking. Balikpapan and Samarinda have great potential for the establishment of a BPRS. Samarinda is the most feasible to establish a BPRS.
Tendensi Wakaf Uang di LWPNU-PWNU YOGYAKARTA
Authors: Ismiati Baiq , Sani Ageng Asmara , Diniyah Umi Saniatun
Published: May 2023

Latar belakang dari penelitian ini adalah permasalahan wakaf uang sebagai salah satu instrumen penggalangan dana masyarakat untuk kepentingan kesejahteraan umat. Instrumen ini belum digarap secara maksimal, baik dari sisi penghimpunan maupun pengelolaannya hal ini berbanding terbalik dengan potensi wakaf yang sangat besar.
Penelitian ini dilakukan di LWPNU-PWNU Yogyakarta. Jenis penelitian menggunakan lapangan (field research). Penelitian ini bersifat kualitatif deskriptif (qualitative descriptive research). Teknik pengumpulan data yang digunakan adalah observasi, wawancara dan dokumentasi. Adapun analisis data yang digunakan analisis data model Miles and Huberman dengan langkah- langkah data collection, data condensa, data display, dan conclusions drawing/verifysing.

Berdasarkan hasil analisis yang telah diuraikan tentang “Tendensi Wakaf Uang di LWPNU-PWNU Yogyakarta (Antara Produktif Dan Konsumtif), maka dapat  dirumuskan; pertama,  lembaga pengelola wakaf tunai oleh LWPNU- PWNU Yogyakarta lebih memberikan pemahaman masyarakat manfaat adanya wakaf uang dan masyarakat melakukan pewakafan di lembaga. Kedua, Mekanisme pengelolaan Wakaf Uang di LWPNU-PWNU Yogyakarta dilaksanakan  menurut  UU wakaf dan peraturan pelaksanaanya diantaranya: Pertama, Proses penghimpunan, yang mana hal ini dilakukan oleh LWPNU- PWNU Yogyakarta dengan sistem bantingan dilakukan melalui kotak wakaf dan sebagainya.  Kedua,  mekanisme  LWPNU-PWNU  Yogyakarta  dalam pengelolaan wakaf uang  terdiri dari penghimpunan, sosialisasi, dan penyaluran dana  3)  Implikasi pengelolaan wakaf uang  di LWPNU-PWNU Yogyakarta terlihat pada tiga hal yakni: bidang sarana ibadah, bidang pendidika, dan bidang ekonomi.

Kata kunci: Wakaf, Pengelolaan Wakaf Uang dan LWPNU-PWNU Yogyakarta.
The Role of Islamic Banks' Financial Performance on Corporate Social Responsibility (CSR)
Authors: Nurdyanzah Muh , Junaidi Junaidi , Sultan Sultan
Published: May 2023

This study aims to obtain empirical evidence of factors that can affect the CSR performance of the Islamic social reporting (ISR) index of Islamic banks, which then interact with moderating variables. The method used is a quantitative method with multiple regression techniques and moderated regression analysis used to analyze the data. The factor used is Islamic social reporting, and the moderating variable is financial performance contained in the annual reports of several Islamic banks in Indonesia. From 2012 to 2021, the population of this study is Indonesian Islamic Commercial Banks (BUS). The sample obtained based on the sample selection criteria is only four Islamic commercial banks with a total of only 40 observations, indicating that the sample is still relatively small and the resulting value is relatively low to explain the company's financial performance. The time series method is used to process the data. The result show ROA and ROE can moderate and strengthen the impact of ISR on firm performance, ISR has a favorable and considerable impact on the financial performance of Islamic banks. The added value of the company is supported theoretically and empirically by this study. For this research to be used as a reference to explain phenomena with existing theories, the hypotheses made are stated descriptively and then accompanied by a Sharia perspective.
Portrait Implementation Muzara’ah Contract Effort Encourage Improvement Community's Economy
Authors: Ishak Ishak , Saepul Saepul , Sabani Akbar
Published: May 2023

The purpose of this study is to describe how the process of implementing profit sharing is carried out by agricultural communities in the District. District Anggeraja. Enrekang and whether the profit-sharing model is following the muzara’ah contract in Islam. There are three main topics discussed in this article, namely (1) The potential for shallot farming (2) The mechanism for implementing the muzara’ah contract in shallot farming (3) The economic impact on the community from shallot farming. This type of research uses qualitative methods which are described descriptively. Sources of research data using primary data and secondary data. To obtain valid data, the authors use data collection methods utilizing observation, interviews, and documentation. The data analysis technique used in this research is data reduction, presenting data, and drawing conclusions. The findings of the results in the study indicate that the concept of profit sharing is carried out by the people of Kec. Anggeraja Kab. Enrekang is called by the term bagessele' which is carried out based on the customs of the local community, namely an agreement between the owner of capital and sharecroppers in the form of an oral statement. In the process of implementing shallot farming profit sharing, all the results obtained from agriculture are totaled as a whole, then reduced by the capital that has been issued, and then divided based on the proportion between sharecroppers and capital owners. The mechanism for implementing the profit sharing used is also following the principles of Islamic law in Ramallah because it refers to the pillars and conditions that have been fulfilled. The distribution of ratios also follows the proportion of profit sharing in the muzara’ah contract, namely ½, 1/3, and ¼ following the mutual agreement.
The Influence of Age, Sex, and Socioeconomic Status on Glycemic Control Among People With Type 1 and Type 2 Diabetes in Canada: Patient-Led Longitudinal Retrospective Cross-sectional Study With Multiple Time Points of Measurement
Authors: Mousavi Seyedmostafa , Tannenbaum Greenberg Dana , Ndjaboué Ruth , Greiver Michelle , Drescher Olivia , Chipenda Dansokho Selma , Boutin Denis , Chouinard Jean-Marc , Dostie Sylvie , Fenton Robert , Greenberg Marley , McGavock Jonathan , Najam Adhiyat , Rekik Monia , Weisz Tom , Willison Donald J , Durand Audrey , Witteman Holly O ,   Diabetes Action Canada Research Questions Prioritization Study
Published: April 2023

Background

Clinical guidelines for most adults with diabetes recommend maintaining hemoglobin A1c (HbA1c) levels ≤7% (≤53 mmol/mol) to avoid microvascular and macrovascular complications. People with diabetes of different ages, sexes, and socioeconomic statuses may differ in their ease of attaining this goal.

Objective

As a team of people with diabetes, researchers, and health professionals, we aimed to explore patterns in HbA1c results among people with type 1 or type 2 diabetes in Canada. Our research question was identified by people living with diabetes.

Methods

In this patient-led retrospective cross-sectional study with multiple time points of measurement, we used generalized estimating equations to analyze the associations of age, sex, and socioeconomic status with 947,543 HbA1c results collected from 2010 to 2019 among 90,770 people living with type 1 or type 2 diabetes in Canada and housed in the Canadian National Diabetes Repository. People living with diabetes reviewed and interpreted the results.

Results

HbA1c results ≤7.0% represented 30.5% (male people living with type 1 diabetes), 21% (female people living with type 1 diabetes), 55% (male people living with type 2 diabetes) and 59% (female people living with type 2 diabetes) of results in each subcategory. We observed higher HbA1c values during adolescence, and for people living with type 2 diabetes, among people living in lower income areas. Among those with type 1 diabetes, female people tended to have lower HbA1c levels than male people during childbearing years but higher HbA1c levels than male people during menopausal years. Team members living with diabetes confirmed that the patterns we observed reflected their own life courses and suggested that these results be communicated to health professionals and other stakeholders to improve the treatment for people living with diabetes.

Conclusions

A substantial proportion of people with diabetes in Canada may need additional support to reach or maintain the guideline-recommended glycemic control goals. Blood sugar management goals may be particularly challenging for people going through adolescence or menopause or those living with fewer financial resources. Health professionals should be aware of the challenging nature of glycemic management, and policy makers in Canada should provide more support for people with diabetes to live healthy lives.
A Tailored mHealth App for Improving Health and Well-Being Behavioral Transformation in UK Police Workers: Usability Testing via a Mixed Methods Study
Authors: Mehra Richa , Pulman Andy , Dogan Huseyin , Murphy Jane , Bitters Fiona
Published: May 2023

Background

When considering the policing environment of 2022, many roles previously in the domain of warranted officers (police officer) are now performed by nonwarranted police staff equivalents. These police staff roles have expanded rapidly into other areas such as investigations, custody, and contact management, which were traditionally seen as police officer functions and put staff under some of the same stresses as police officers. A UK police force requested help in investigating technologies that could be used to improve health and well-being for both officers and staff.

Objective

The aim of this study was to create a health and well-being app for police officers and staff, which considered the unique requirements of the users throughout the designing, building, prototyping, and testing stages.

Methods

This study involved quantitative approaches (demographic web-based survey questions and the System Usability Scale) and qualitative approaches (open web-based survey questions and semistructured interviews). Unsupervised usability testing of a prototype app was undertaken by members (N=48) of the commissioning client using their smartphones. After completing a preregistration application for screening purposes, participants downloaded a trial version of the app. Then, they completed a web-based questionnaire after testing the app for 10 days. A subsample of participants (9/48, 19%) was interviewed. Deductive thematic analysis was undertaken to identify key themes and subthemes.

Results

Data collected during usability testing concerned the 6 domains of the app—food and diet, activity, fluid intake, sleep, good mental health, and financial well-being—and informed the creation of improved design during prototyping. Some usability and design issues and suggestions for improvements were also addressed and implemented—including shift management and catch-up cards—during this cycle of development.

Conclusions

This study highlights the importance of coparticipation with officers and staff across the entire development cycle, to coproduce a human-centered design methodology to enable the development of a considered and user-centered solution. It demonstrates the need for producing a multifunctional tool rather than focusing purely on an individual element for this user group. It also highlights how linking and being able to track optional, personalized elements of health data against one another, cross-referenced to individual shift patterns, might help to inform and provide users with a chance for reflection and therefore influence behavior change.
Evaluating Listening Performance for COVID-19 Detection by Clinicians and Machine Learning: Comparative Study
Authors: Han Jing , Montagna Marco , Grammenos Andreas , Xia Tong , Bondareva Erika , Siegele-Brown Chloë , Chauhan Jagmohan , Dang Ting , Spathis Dimitris , Floto R Andres , Cicuta Pietro , Mascolo Cecilia
Published: May 2023

Background

To date, performance comparisons between men and machines have been carried out in many health domains. Yet machine learning (ML) models and human performance comparisons in audio-based respiratory diagnosis remain largely unexplored.

Objective

The primary objective of this study was to compare human clinicians and an ML model in predicting COVID-19 from respiratory sound recordings.

Methods

In this study, we compared human clinicians and an ML model in predicting COVID-19 from respiratory sound recordings. Prediction performance on 24 audio samples (12 tested positive) made by 36 clinicians with experience in treating COVID-19 or other respiratory illnesses was compared with predictions made by an ML model trained on 1162 samples. Each sample consisted of voice, cough, and breathing sound recordings from 1 subject, and the length of each sample was around 20 seconds. We also investigated whether combining the predictions of the model and human experts could further enhance the performance in terms of both accuracy and confidence.

Results

The ML model outperformed the clinicians, yielding a sensitivity of 0.75 and a specificity of 0.83, whereas the best performance achieved by the clinicians was 0.67 in terms of sensitivity and 0.75 in terms of specificity. Integrating the clinicians’ and the model’s predictions, however, could enhance performance further, achieving a sensitivity of 0.83 and a specificity of 0.92.

Conclusions

Our findings suggest that the clinicians and the ML model could make better clinical decisions via a cooperative approach and achieve higher confidence in audio-based respiratory diagnosis.
Hesitancy to Undergo SARS-CoV-2 Rapid Antigen Testing in China: Nationwide Cross-sectional Study (Preprint)
Authors: Lu Zhen , Fu Leiwen , Yang Luoyao , Tian Tian , Gao Yanxiao , Meng Xiaojun , Zou Huachun
Published: May 2023

BACKGROUND

SARS-CoV-2 rapid antigen testing (RAT) could be a useful supplementary test to diagnose larger numbers of acute asymptomatic infections and alleviate the limitations of polymerase chain reaction testing. However, hesitancy to undergo SARS-CoV-2 RAT may compromise its implementation.

OBJECTIVE

We aimed to understand the prevalence and correlates of hesitancy to undergo RAT among adults not infected with SARS-CoV-2 in mainland China.

METHODS

A nationwide cross-sectional survey on hesitancy to undergo SARS-CoV-2 RAT was conducted among adults not infected with SARS-CoV-2 in mainland China between April 29, 2022, and May 10, 2022. Participants completed an online questionnaire that covered the following COVID-19–related factors: sociodemographic characteristics, experiences of COVID-19 restrictions and knowledge of COVID-19, and attitude toward COVID-19 and its screening. This study was a secondary analysis of data from the survey. We compared the characteristics of participants by hesitancy to undergo SARS-CoV-2 RAT. Thereafter, logistic regression with a sparse group minimax concave penalty was used to identify correlates of hesitancy to undergo RAT.

RESULTS

We recruited 8856 individuals with diverse demographic, socioeconomic, and geographic characteristics in China. Eventually, 5388 participants (valid response rate of 60.84%; 52.32% [2819/5388] women; median age 32 years) were included in the analysis. Among the 5388 participants, 687 (12.75%) expressed hesitancy to undergo RAT and 4701 (87.25%) were willing to undergo RAT. Notably, those who were from the central region (adjusted odds ratio [aOR] 1.815, 95% CI 1.441-2.278) and those who received COVID-19 information from traditional media (aOR 1.544, 95% CI 1.279-1.863) were significantly more likely to report hesitancy to undergo RAT (both P<.001). However, those who were women (aOR 0.720, 95% CI 0.599-0.864), were older (aOR 0.982, 95% CI 0.969-0.995), had postgraduate education (aOR 0.612, 95% CI 0.435-0.858), had children (<6 years old) and elders (>60 years old) in the family (aOR 0.685, 95% CI 0.510-0.911), had better knowledge about COVID-19 (aOR 0.942, 95% CI 0.916-0.970), and had mental health disorders (aOR 0.795, 95% CI 0.646-0.975) were less likely to report hesitancy to undergo RAT.

CONCLUSIONS

Hesitancy to undergo SARS-CoV-2 RAT was low among individuals who were not yet infected with SARS-CoV-2. Efforts should be made to improve the awareness and acceptance of RAT among men, younger adults, individuals with a lower education or salary, families without children and elders, and individuals who access COVID-19 information via traditional media. In a reopening world, our study could inform the development of contextualized mass screening strategies in general and the scale-up of RAT in particular, which remains an indispensable option in emergency preparedness.