bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluate the Efficacy of Guava-Derived CuO, and ZnO Nanocomposite Coating on Shelf life of Grapes
Authors: Singh Neha , Mittal Avneesh , Garg Meenakshi , Trivedi Rishabh , Kumar Pola Pavan , Sadhu Susmita Dey , Chopra Rajni
Published: November 2023

Pectin’s anionic heteropolysaccharide structure makes it suitable for coating metal nanoparticles (MPNs) by preventing their accumulation and thus, improves MPNs acceptability for formulation of edible coatings. The presence of functional moiety preferably, hydroxyl group and carboxylic acid in pectin promote their covalent bonding with metal nanoparticles, proteins, and other biomolecules. Accordingly, the present investigation explored the efficacy of guava-derived pectin-based zinc oxide (ZnO) and copper oxide (CuO) nanocomposite biopolymer coatings on the quality attributes and shelf-life extension of berries. The solvent casting and chemical reduction methods were used to synthesized guava-derived ZnO and CuO nanoparticles coatings, respectively. Simultaneously, berries submerged in three different biopolymer coatings viz., guava-derived pectin (GDP), GDP/ZnO and GDP/CuO for three minutes and stored at refrigerated temperature (i.e., 7oC) along with uncoated samples. The samples were evaluated for physicochemical changes and sensorial parameters at an interval of 2 days for 19 days of storage period and FTIR spectroscopy. The nanocomposite coatings were effective in reducing the berries' weight loss, water activity and minimized the reduction in pH, and titratable acidity. Comparably, an increase in total soluble solids (TSS) were observed in all coated samples but it was lower than uncoated ones. Furthermore, compared to controlled and other coated samples, only ZnO-coated berries had retained their texture, odor and were of acceptable quality to a lesser extent until 19 days of storage. The results of FTIR spectroscopy reveals the presence of alcohol and carboxylic acid group in the GDP structure. Supposedly, nanocomposite coatings could be harnessed as an active biopolymer packaging material that can prolong the lifespan and maintain the quality of grapes for an adequate period (at least two weeks) under refrigerated conditions.
MSCs play a vital function in Tibial cortex transverse transport surgery
Authors: Deng Baoping , Li Junjie , Weng Jiacong , Ge Xiaoyong , Xu Jing , Zheng Hongmei , Deng Weiping
Published: November 2023

Background
Tibial cortex transverse transport (TTT) has a good clinical effect in the treatment of diabetic foot, and the postoperative indexes of patients have been significantly improved. However, the mechanism of TTT on the increased expression of angiogenesis related factors and wound healing is still unclear
Methods
Diabetic foot model with tibial bone marrow purging was established to observe the effect of MSCs combined with TTT on angiogenesis and wound healing. The angiogenesis and wound healing process was evaluated by vascular perfusion, immunohistochemistry and Western blotting.
Results
After treatment with TTT surgery and MSCS injected into the myeloablated bone marrow cavity, the results showed faster wound healing and better skin recovery, angiography results showed that more new blood vessels were observe, and immunohistochemical staining and Western blotting detection also showed that TTT technology promoted CD31 expression through MSCs of the bone marrow cavity.
Conclusion
MSCs in the bone marrow cavity play a vital function in TTT surgery.
Lessons Learned: Establishing a CLIA-Equivalent Laboratory for Targeted Mass Spectrometry Assays – Navigating the Transition from Research to Clinical Practice
Authors: Han Chia-Li , Lai Chi-Ting , Reyes Aaron James , Yang Hao-Chin , Lu Jin-Ying , Shih Shyang-Rong , Chen Kuen-Yuan , Hoofnagle Andrew N , Yu Sung-Liang , Bocik William , Hiltke Tara , Chiu Huan-Chi , Wan Ching-Yi , Rodriguez Henry , Zhang Victoria , Chen Yu-Ju
Published: November 2023

Mass spectrometry (MS) assays offer exceptional capabilities in high multiplexity, specificity, and throughput. As proteomics technologies continue advancements to identify new disease biomarkers, transition of these innovations from research settings to clinical applications becomes imperative. To meet the rigorous regulatory standards of clinical laboratories, development of a clinical protein MS assay necessitates adherence to stringent criteria. To illustrate the process, this project focused on using thyroglobulin (Tg) as a biomarker and an immuno-multiple reaction monitoring (iMRM) MS-based assay as a model for establishing a Clinical Laboratory Improvement Amendments (CLIA) compliant laboratory within the Centers of Genomic and Precision Medicine, National Taiwan University. The chosen example also illustrates the clinical utility of MS assays to complement conventional immunoassay-based methods, particularly in cases where the presence of autoantibodies in 10–30% of patients hinders accuracy. The laboratory design entails a comprehensive coordination in spatial layout, workflow organization, equipment selection, ventilation systems, plumbing, electrical infrastructure, documentation procedures, and communication protocols. Practical aspects of the transformation process, including preparing laboratory facilities, testing environments, instrument validation, assay development and validation, quality management, sample testing, and personnel competency, are discussed. Finally, concordant results in proficiency testing demonstrate the harmonization with the University of Washington Medical Center and the quality assurance of the CLIA-equivalent Tg-iMRM MS assay established in Taiwan. The realization of this model protein MS assay in Taiwan highlights the feasibility of international joint development and provides a detailed reference map to expedite the implementation of more MS-based protein assays in clinical laboratories for patient care.
Efficacy of a stable multivalent broadly protective subunit vaccine platform against SARS-CoV-2 variants of concern
Authors: Banerjee Arinjay , Garg Ravendra , Liu Qiang , Kessel Jill van , Asavajaru Akarin , Uhlemann Eva-Maria , Joessel Morgane , Hamonic Glenn , Khatooni Zahed , Kroeker Andrea , Lew Jocelyne , Scruten Erin , Pennington Paul , Deck William , Prysliak Tracy , Nickol Michaela , Apel Falko , COURANT Thomas , kelvin Alyson , Kessel Andrew Van , COLLIN Nicolas , Gerdts Volker , Köster Wolfgang , Falzarano Darryl , Racine Trina
Published: November 2023

The emergence and ongoing evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has highlighted the need for rapid vaccine development platforms that can be updated to counteract emerging variants of currently circulating and future emerging coronaviruses. Here we report the development of a “train engine and car” subunit vaccine platform that contains a SARS-CoV-2 Wuhan S1 protein linked to a series of flexible receptor binding domains (RBDs) derived from SARS-CoV-2 variants of concern (VOCs). We demonstrate that these linked subunit vaccines when combined with the SWE adjuvant are immunogenic in Syrian hamsters and subsequently provide protection from challenge with SARS-CoV-2 VOCs Omicron, Delta, and Beta. Importantly, the bivalent and trivalent vaccine candidates offered protection against some heterologous SARS-CoV-2 VOCs that were not included in the vaccine design, demonstrating the potential for broad protection against a range of different VOCs. Furthermore, these formulated vaccine candidates were stable at 2–8 °C for up to 12 months post-formulation, highlighting their utility in low-resource settings. Indeed, our vaccine platform will enable the development of safe and broadly protective vaccines against emerging betacoronaviruses that pose a significant health risk for humans and agricultural animals.
Anti-arthritic activity of Pogostemon quadrifolius
Authors: Madhiri Ramya , Barik Rakesh
Published: November 2023

Aim of the study: To investigate anti-arthritic activity of Aqueous methanolic extract of Pogostemon quadrifolius (AMEPQ) in Freund’s complete adjuvant (FCA)-induced arthritis in rats.
Methods: The AMEPQ was prepared and subjected to acute oral toxicity in mice and tested against FCA induced arthritis in rats. Arthritis assessment was done by measuring – paw volume, joint diameter, pain threshold, thermal hyperalgesia, mechanical nociceptive threshold and body weight.
Haematological, serum, biochemical and in vivo anti-oxidant parameters were measured on the last day of the study. Histopathological and radiological analyses of ankle joints were also done. MEPQ was administered at the dose of 100, 200 and 400 mg/kg body weight.
Results: MEPQ dose dependently showed anti-arthritic activity which was evident with decrease in paw volume, joint diameter and increase in pain threshold, paw withdrawal latency, mechanical nociceptive threshold and body weight when compared to arthritic control group. AMEPQ (400 and 200 mg/kg) exhibits signiﬁcant (P < 0.001 and P < 0.01, respectively) anti-arthritic activity by increasing levels of RBC, Hb and by decreasing levels of WBC, platelets and also serum C-reactive protein (CRP) and Rheumatoid factor (RF). The anti-arthritic activity was also conﬁrmed with the altered biochemical parameters (AST, ALT, ALP and total protein level) and anti-oxidant parameters (SOD, MDA and GSH). MEPB (400 and 200 mg/kg) and diclofenac (10 mg/ kg) also inhibited joint destruction (histopathological and radiological analysis).
Conclusion: P. quadrifolius may be a potential preventive or therapeutic candidate for the treatment of inﬂammation and arthritis.
Impact of Long-COVID on Cardiac Arrhythmias: A Multi-Center Study from the Middle Euphrates Region, Iraq
Authors: Sadiq Alaa M. , Al-Amran Fadhil
Published: November 2023

Long-COVID, characterized by prolonged symptoms following an acute COVID-19 infection, has emerged as a significant public health concern. Cardiac arrhythmias are among the critical sequelae associated with long-COVID. This study aims to assess the incidence and nature of cardiac arrhythmias in long-term patients. This retrospective cohort study involved 340 patients diagnosed with long-term COVID-19, recruited from various hospitals in the Middle Euphrates region throughout 2022. The majority of the cohort were male, with ages ranging from 25 to 89 years. Data on cardiac arrhythmias were collated and analyzed. The study found a notable incidence of cardiac arrhythmias in long-COVID-19 patients, with variations across different age groups and a predominance in male patients. The types of arrhythmias and their severity differed significantly, indicating the diverse impact of long-term on cardiac health. The findings suggest a significant association between long-COVID-19 and the development of cardiac arrhythmias. The study highlights the need for vigilant cardiac monitoring in long-COVID-19 patients and underscores the importance of further research to understand the underlying mechanisms and to develop effective management strategies.
Long-Term COVID-19 and Its Accelerating Impact on Atherosclerotic Cardiovascular Diseases in Iraq
Authors: Sadiq Alaa M. , Al-Amran Fadhil
Published: November 2023

Background:The COVID-19 pandemic's long-term effects on cardiovascular health, particularly regarding atherosclerotic diseases, are of increasing concern.Methods:In this retrospective cohort study, 450 patients from various Iraqi provinces who had recovered from COVID-19 were assessed over 12 months to evaluate the prevalence and severity of atherosclerotic cardiovascular diseases (CVD).Results:There was a significant increase in atherosclerotic changes among patients with a history of long-term COVID-19 compared to those without. A notable correlation was observed between the severity of post-COVID symptoms and the extent of atherosclerotic manifestation, across different demographic groups and geographical locations within Iraq.Conclusions:The study concludes that long-term COVID-19 may contribute to the accelerated development of atherosclerotic CVD. These findings underscore the need for enhanced cardiovascular monitoring and intervention strategies in patients recovering from COVID-19, particularly those with severe or prolonged symptoms.
Polyethylene Glycol and Caspase Inhibitor Emricasan Alleviates Cold Injury in Primary Rat Hepatocytes
Authors: Chen Huyun , Ellis Bradley W. , Dinicu Antonia T. , Mojoudi Mohammadreza , Wilks Benjamin T. , Tessier Shannon N. , Toner Mehmet , Uygun Korkut , Uygun Basak E.
Published: November 2023

Current methods of storing explanted donor livers at 4°C in University of Wisconsin (UW) solution result in loss of graft function and ultimately leads to less-than-ideal outcomes post transplantation. Our lab has previously shown that supplementing UW solution with 35-kilodalton polyethylene glycol (PEG) has membrane stabilizing effects for cold stored primary rat hepatocytes in suspension. Expanding on past studies, we here investigate if PEG has the same beneficial effects in an adherent primary rat hepatocyte cold storage model. In addition, we investigated the extent of cold-induced apoptosis through treating cold-stored hepatocytes with pan caspase inhibitor emricasan. In parallel to storage at the current cold storage standard of 4°C, we investigated the effects of lowering the storage temperature to –4°C, at which the storage solution remains ice-free due to the supercooling phenomenon. We show the addition of 5% PEG to the storage medium significantly reduced the release of lactate dehydrogenase (LDH) in plated rat hepatocytes and a combinatorial treatment with emricasan maintains hepatocyte viability and morphology following recovery from cold storage. These results show that cold-stored hepatocytes undergo multiple mechanisms of cold-induced injury and that PEG and emricasan treatment in combination with supercooling may improve cell and organ preservation.
Investigations of the shallow bedrock using the seismic refraction method – A case study in New Qena City, Eastern Desert, Egypt
Authors: Gowad Ahmed M. Abdel , El-Haddad Assem E. , Aglan Mohamed I. , Hamed Ahmed
Published: November 2023

The seismic refraction technique has demonstrated its efficiency as a cost-effective geophysical approach for bedrock investigation, which is very important for major construction projects. In the eastern part of New Qena City, along Qena-Safaga Road in the Eastern Desert of Egypt, construction of many domestic facilities is planned. Therefore, a prior site investigation focusing on bedrock is required to validate the site for construction and other projects. In this study, a site investigation of the eastern part of New Qena City is conducted using the seismic refraction method to estimate the depth and thickness of the bedrock and to present the surface structural features affecting the area. Ten seismic refraction profiles were measured in the area. The results of tomographic modeling show that the bedrock consists of three layers, with the bedrock represented by the mudstone unit of the Pliocene Durri Formation. This layer is located at a shallow depth and varies in thickness in the area. The seismic velocity sections show that the layer is characterized by relatively low velocities as well as lateral velocity variations. This is interpreted to be due to the clay content of the layer, the high degree of fracturing, and the lateral facies variation. Therefore, the layer could undergo geotechnical problems that could affect future construction projects in the area. Four subsurface faults were also detected in the velocity sections created by the tomographic inversion.
MODEL FOR APPOINTMENT OF STUDENT ASSISTANTS ACCORDING TO THE NEEDS OF UNIVERSITY PROJECTS
Authors: Monge Poltronieri Steve
Published: November 2023

Human Resources administration in the XXI century has become one of the main topics to whom organizations and projects of course must be addressed, since it represents its main resource. Projects are created to satisfy a need however, reaching its goals is intrinsically connected to the existent human talent. It is for this reason that counting with a human resources model is a key element in any project. From the moment the profiles are defined to the recruiting, selection, induction, and staff development process.It is fundamental to design a model of student assistant that allows programs and projects attract and strength themselves with the best qualified human talent to reach the established goals, must be appropriately established.In order to do this, an interview to the program and projects coordinators must be applied to find out elements such as job position profiles, the recruiting, selection and induction process as well as the training and benefits to student assistants.Finally, a series of recommendations are established to create a model of human talent specifically designed to student assistants.
EPIDIDYMO-ORCHITIS IN SPINAL CORD INJURY PATIENTS ON CIC: A CASE SERIES
Authors:   Physiatrist, Almas Hospital, Malappuram., Sherin P.P Shabeeba , S. Indulekha ,   Postgraduate Resident, Department of Physical Medicine, and Rehabilitation, AIIMS, Rishikesh., a Aditi ,   Postgraduate Resident, Department of Physical Medicine, and Rehabilitation, AIIMS, Rishikesh., Rama Krishna S. Teja ,   3rd year PG Community and Family Medicine, AIIMS Rishikesh., J. Shibu ,   Physiatrist, Corolla Hospital, Thiruvananthapuram.
Published: November 2023

Clean intermittent catheterization (CIC) is an excellent technique in minimising urinary complications in SCI patients. Its introduction has dramatically changed the Urological management of SCI patients. However, two long term problems remain: that of urethral tolerance, and that of epididymitis, the consequence of persistent urethroprostatic infection. Here, we report an unexpected complication of CIC in 3 patients with SCI.
GLP-1 RECEPTOR AGONISTS AND CARDIOVASCULAR OUTCOMES AND MORTALITY IN TYPE 2 DIABETES. A NEW APPRAISAL
Authors:   Armed Forces Hospital Southern Region, Ministry Of Defense, Kingdom Of Saudi Arabia., Awad Alahmary Fatimah , Abdulaziz Turki Ibrahim ,   Armed Forces Hospital Southern Region, Ministry Of Defense, Kingdom Of Saudi Arabia., Mushabbab Saad Alahmari Meshari ,   Erg Alhena, Ahad Rufaidah, Asser Region, Ministry Of Health, Kingdom Of Saudi Arabia., Awadh Misfer Alahmari Amnah ,   Abha, Asser Region, Ministry Of Health, Kingdom Of Saudi Arabia., Mosa Ali Asiri Faisal ,   Maternity and Children Hospital, Ministry Of Health, Kingdom Of Saudi Arabia., Awadh Mesfer Alahmari Maryam ,   Medical Student, King Khalid University, Kingdom Of Saudi Arabia.
Published: November 2023

Diabetes mellitus is a chronic disease prevalence of which is high and continually growing. Cardiovascular disease continues to be the leading cause of death in patients with T2DM. The prevention of cardiovascular complications and the cardiovascular safety of treatments should be a primary objective when selecting treatment. Among all the drugs available, the compounds known as glucagon-like peptide-1 receptor agonists (GLP-1 RAs) appear to be not just innocuous in terms of CVD but indeed to be beneficial. GLP-1 RA actions not only translate on an improvement of well-known cardiovascular risk factors such as glycaemic control, dyslipidaemia, weight, or arterial hypertension but also might show benefits on endothelial function, coronary ischaemia, and heart failure. On the other hand, recent clinical trials aimed at studying cardiovascular episodes have been conducted with GLP-1 RAs. Only liraglutide and semaglutide have shown superiority in cardiovascular benefit compared with placebo. Although many of the mechanisms by which liraglutide and semaglutide produce a cardiovascular benefit are still unknown it would be desirable for these benefits to be incorporated into the therapeutic algorithms routinely used in clinical practice. The purpose of this review is to explore GLP-1 RA actions not only in cardiovascular risk factors (glucose, weight, and hypertension) but also the possible effects on established cardiovascular disease.
AN AGENT BASED MODEL TO IMPROVE TRAFFIC FLOW AND ASSESS THE IMPACT OF SMART TRAFFIC LIGHT
Authors:   Universite Felix Houphouet Boigny(UFHB)., Konate Ngolo , Richard Batiebo Mory ,   Universite Virtuelle de Cote dIvoire (UVCI)., Diarra Mamadou ,   Universite Felix Houphouet Boigny(UFHB)., Komi Mensah Agboka ,   International Centre of Insect Physiology and Ecology (ICIPE).
Published: November 2023

The Traffic in developing country undergoes severs perturbations due to either a misunderstanding of the physical phenomenon or in bad calibration of equipments such as traffic light. Due to this high complexity, mathematical models fail to well represent different scenario. Those issues are mostly due to the high amount of parameter which should be taken into consideration when dealing with some mathematical model and the drivers behaviors. Since agent-based model is a computational simulation that represents individual entities (called agents) and their interactions within a defined environment. It is a powerful tools used to investigate human behavior impact in a mathematical model. Therefore, this paper proposed a novel agent-based approach framework for effectively making traffic light timing dynamic according to traffic density. Moreover, based on different rules such as lane changing, stop and goat the traffic light, we develop an Agent based model to represent the relationships between the traffic changing and its environment. The use of agent-based models for traffic light time optimization offers a more granular, adaptive, and integrative approach that better capture the complexities of real-world traffic scenarios. Finally, the experimental result is applied on synthetic data and compared to other results in almost the same context for both static and dynamic traffic light. The results show that the travel time distribution is less for dynamic traffic light.
A PROSPECTIVE STUDY TO ASSESSTHE FUNCTIONAL OUTCOMES OFDIAPHYSEAL BOTH BONE FRACTURESOF THE FOREARM IN ADULTS TREATEDBY OPEN REDUCTION AND INTERNALFIXATION WITH DYANAMICCOMPRESSION PLATE
Authors: Ravikumar V. , Sajid JH Muhammad
Published: November 2023

Indroduction: Forearm fractures can be regarded as articular fractures as slight deviations in the spatial orientation of the radius and ulna will significantly decrease the forearmÂ’s rotational amplitude and thereby impair the positioning and function of the hand. Thus, the management of these fractures deserve special attention as their treatment is not the same as the treatment of other diaphyseal fractures.Open reduction and internal fixation for diaphyseal fracture in the adults are generally accepted as the best method of treatment, even though closed reduction may be achieved. Objective: The Objective of this study is to evaluate the functional outcome after open reduction and internal fixation of the forearm diaphyseal fractures by Dynamic Compression Plate (DCP). Methods: This is a prospective study of 72 cases of diaphyseal both bone forearm fractures in adults who attended casualty and of Government Medical College Hospital, Kozikkode and were treated by open reduction and internal fixation with dynamic compression plating between September 2020 to August 2022. Results: The functional outcome as per DASH scoring system in dynamic compression plating (DCP) group was that 85 % (61 patients) had excellent results, 15 % (11 patients) had good results with no patient having fair and poor results. Conclusion: Fixation with Dynamic Compression Plate has stood the test of time and provides excellent fixation. DASH is a widely accepted standardized scoring system to assess upper limb function. In comparison with few of the previous studies our results are better in terms of functional outcome.
EFFICACY OF TTK CHITRA MECHANICAL HEART VALVE VERSUS ST JUDE MECHANICAL HEART VALVE IN AORTIC VALVE REPLACEMENT
Authors: Balaiah Mariappan , Lakshmanan Satish , S. Manimaaran
Published: November 2023

Background: For patients having aortic valve replacement (AVR), the St. Jude and TTK Chitra mechanical heart valves are both often utilised in daily practise. The effectiveness of these valves is still up for discussion, though. Therefore, the purpose of this study was to investigate the outcomes of patients who underwent AVR with a St. Jude mechanical valve (SJMV) or a Chitra heart valve prosthesis (CHVP). Methods: We performed a single-center prospective cohort study among patients undergoing isolated aortic valve replacement at the MMC Institute of Cardiology and Cardiothoracic Vascular Surgery in Chennai between January 2022 and June 2023. An aortic valve replacement was necessary in 60 patients in total. Thirty cases underwent AVR with the St. Jude valve and the remaining thirty cases were treated with the TTK Chitra valve. Data were collected and analysis was carried out using the Statistical Package for Social Sciences. Results: Group SJ had 90% of instances with RHD, whereas group C had 93.3% of cases with RHD. In groups SJ and C, calcified AV was observed in 33.3% and 40% of patients, respectively, and bicuspid AV in 26.7% and 23.3% of cases, respectively. Both group SJ and group Cs baseline cardiac parameters were determined to be comparable. Both at baseline and one month after surgery, the mean EF, LVSD, and LVDD in groups SJ and C were comparable. At one month after surgery, both groups mean gradient across the aortic valve was significantly lower than baseline. Groups SJ and C had mortality rates of 6.7% and 3.3%, respectively. Conclusion: Aortic valve replacement patients in low-resource countries can now explore cardiac surgery because to the TTK Chitra mechanical heart valve, which provides comparable results at around half the cost of an imported St. Jude mechanical heart valve with similar efficacy and safety.
THE EFFECTS OF SUBLIMINAL MESSAGES ON HUMAN ATTITUDE CHANGE AND EFFECTIVE ADVERTISING
Authors:   Ph.D. Condidate and Instructor in Sociology Department at Bamyan University, Bamyan, Afghanistan., Ahmadi Ramazan , Reza Akbari Mohammad ,   Senior Teaching Assistant, Instructor in Sociology Department at Bamyan University, Bamyan, Afghanistan.
Published: November 2023

This discussion delves into the intricate realms of self-awareness and unconsciousness, shedding light on their profound influence on human behavior and society. Awareness, spanning from the womb to the grave, defines our conscious existence, while the unconscious silently records every sensory input, guiding our emotions and actions. Notably, the unconscious can be harnessed to manipulate individuals and communities through subliminal messages, a powerful tool wielded by advertising, marketing, and media. The infamous 1957 experiment by James Vicary, flashing Eat Popcorn! Drink Coca-Cola! in a cinema, exemplifies how subtle suggestions can shape consumer choices. Visual symbols in advertising can evoke feelings of credibility in consumers, perpetuating the allure of certain products or services. However, its essential to be cautious, especially regarding children and their exposure to digital games, which may harbor hidden subliminal messages impacting their future behavior. The study underscores the sway of subliminal messages in advertising, ideology propagation, and economic interests. Nevertheless, the impact varies with age, gender, culture, and time, aligning with individual desires and beliefs. Negative usage of subliminal messages, when they are forced upon consumers, becomes detrimental to individuals and society. Therefore, comprehensive control measures and penalties for subliminal advertising are imperative. Particularly, vigilance is required in monitoring childrens media consumption to shield them from harmful messages.In conclusion, subliminal messages hold immense potential for both harm and benefit. While they can be tools for manipulation, they can also aid personal growth and societal harmony. Striking a balance requires vigilance, regulation, and ethical considerations, ensuring that subliminal messages serve as a force for positive change rather than manipulation.
OPTIMIZATION DESIGN OF INLET AND OUTLET FOR A TURBINE POWER GENERATION EQUIPMENT
Authors:   Shenyang Ligong University School of Mechanical Engineering, Shenyang, Liaoning 110159, China., Yang Wenxin , Shu Qilin ,   Shenyang Ligong University School of Mechanical Engineering, Shenyang, Liaoning 110159, China.
Published: November 2023

To enhance the operational efficiency of turbine generators, this study takes the air intake structure of the U.S. military turbine fuzes and a self-designed structure as research subjects. By employing the numerical simulation software Fluent, we compared the turbines efficiency under various structural parameters. The results indicate that the U.S. militarys intake structure is not suitable for long intake duct types the turbines efficiency peaks when the diameter at the end of the intake duct is approximately 1.5 times that of the turbines radius. Future improvements in efficiency could be achieved by adjusting the dimensions and the matching relationship between the turbine, the intake duct, and the internal flow field.
NAVIGATING THE FUTURE: THE TRANSFORMATIVE IMPACT OF EMERGING TRENDS IN B-SCHOOL LIBRARY MANAGEMENT SYSTEMS ON LIBRARY USERS
Authors:   Librarian, Xavier Institute of Management and Entrepreneurship (XIME), Bangalore., Kalisdha A.
Published: November 2023

Business school libraries, commonly referred to as B-School libraries, are experiencing a significant shift as they embrace digital transformations. Within this evolving landscape, the trends in library management systems are creating a profound impact on library users. This research article embarks on an exploration of how these emerging trends-automation, data analytics, accessibility, and technology integration-are shaping the experiences of students, faculty, and researchers. By delving into these aspects, we aim to underscore the evolving and pivotal role of libraries in enhancing the user experience and bolstering academic success in the realm of business education.
SPORTS PRACTICES AND VIOLENCE AMONG YOUNG MOROCCANS FROM DIFFERENT SOCIAL CLASSES: A SOCIOCULTURAL PERSPECTIVE
Authors:   Department of Educational Sciences. Research Team School & SocietyRegional Center for Education and Training Professions Rabat. Morocco., Essiyedali Abdellah
Published: November 2023

The practice of sport is certainly characterised by a desire to go beyond ones abilities in order to achieve a good performance. Within this framework, we can often witness intense interactions that could easily tip over into different forms of violence. This sociological study is part of this context, and its aim is to focus on the impact of social representations on violence in sport. The aim of our research is, on the one hand, to identify the types of violence in relation to the properties of each sport and, on the other hand, to study the impact of the groups to which one belongs (socio-cultural aspect) on the construction of social representations in relation to the practice of competitive sport and, more specifically, violent behaviour. Three competitive sports were chosen: tennis, judo and football. social. The selected population consisted of 113 young amateur athletes, 15 parents and 06 coaches. We opted for a mixed approach to our research methodology, using both questionnaire and interview techniques. Analysis of the quantitative data showed that each sport was dominated by a particular social category. In football, 75% of participants belonged to a disadvantaged social class. Judo seems to attract young people from an average social category (62%), whereas in tennis 69% of participants belong to a privileged social class. The second observation concerns the distribution of the typology of violence, which seems to follow the logic of a socio-cultural distribution in terms of social class.
EXPERIMENTAL STUDY OF ATIBALA (ABUTILON INDICUM LINN SWEET) ROOT WITH EQUAL QUANTITY OF SUGAR (SITA) AND COW MILK (GODUGDDHA) IN RELATION TO ANTI-DIABETIC ACTIVITY IN STREPTOZOTOCIN INDUCED ALBINO WISTAR RATS
Authors:   Ph.D Scholar, Department of Dravyaguna Vigyan, PDEAS College of Ayurved & Research Centre Nigdi, Pune Maharashtra, India., Dalvi K.V. , D. Lad Meenal ,   Professor& HOD, Department of Dravyaguna Vigyan, PDEAS College of Ayurved & Research Centre Nigdi, Pune Maharashtra, India.
Published: November 2023

Background: Diabetes mellitus, a clinical syndrome developed due to absolute or relative deficiency of insulin and it is mainly characterized by hyperglycemia. It has high prevalence and it is fast gaining status of potential epidemic. Thats why many synthetic drugs are available to treat the diabetes which is costly and giving serious side effects after long use. The herbs are safe and cost effective to treat diabetes. Ayurved classic (Bhavapraksh Nighantu) mentioned Atibala root with Sita (sugar) and Godugddha (Cow milk) have anti-diabetetic activity. As the Diabetes mellitus is most considerable disease by ethical issues hence it is decided to evaluate anti-diabetic activity of Atibala with sugar and cow milk in streptozotocin induced Albino Wistar rats. Aim and Objectives: To study Atibala root with equal quantity of sugar and cow milk as anti-diabetic activity. Methodology: In this study, 30 Albino Wistar rats will be divided randomly into 5 groups (6 in each). Test drugs will be administered for 21 days. The random blood glucose will be measured 0, 7, 14 & 21th days of drug administered. Anti-diabetic activity will be evaluated on biochemical parameter 0 day & at 21thday and on 22th day histopathological study of pancreas. Results: Changes will be observed in the objective outcomes. Conclusion: Atibala root with equal quantity of sugar and cow milk will have anti-diabetic activity.
SYNCHRONOUS BILATERAL BREAST CANCER RIGHT HER 2 POSITIVE AND LEFT HER 2 NEGETIVE- A CASE REPORT
Authors:   Pursuing Pharm D (Doctor of Pharmacy) BhaskarPharmacy College, JNTU, Moinabad, Hyderabad, Telengana, India., Junaid Javed Mohammed , K. Sanath ,   MBBS, DNB (Medical Oncology) Department of Medical Oncology, Basavatarakam Indo American Cancer Hospital & Research Institute, Hyderabad, Telengana, India.
Published: November 2023

Bilateral breast cancers (BBCs) represent 2â€“11% of breast cancers. The diagnosis of breast cancer at the same time or up to 6 months in both breasts is known as Synchronous bilateral breast cancer (s-BBC).[1,2]In about 15% to 20% of breast cancers, the cancer cells make too much of a growth-promoting protein known as HER2. These cancers, known as HER2-positive breast cancers, tend to grow and spread more aggressively than HER2-negative breast cancers. Targeted drug therapy uses medicines that are directed at (target) proteins on breast cancer cells that help them grow, spread, and live longer. Anti-HER2 therapies (also called as HER2 inhibitors or HER2 targeted therapies) are a class of medicines used to treat all stages of HER2-positive breast cancer and certain HER2-low breast cancers.Trastuzumab is currently used sequentially after completion of anthracycline-based chemotherapy as a single agent or in combination with taxanes. In this case report we present a female 51 year old patient with synchronous bilateral breast cancer Left breast wasHER2 negative cT2N0M0, stage I and Right breast was HER2 positive cT2N2M0 stage Ia, both breast cancers were hormone receptor positive. The patient was administered six cycles of Inj. genexol-PM, Inj. carboplatin, Inj. pertuzumab, Inj. trastuzumab, Inj. Pegasta as NAC, Followed by bilateral radical mastectomy, patient showed a complete tumor reduction with residual node in right breast contrary to left breast which showed partial response. (Left breast ypT1N0 (sn)M0 and right breast ypT0N1aM0).
GESTÃO ESCOLAR PARA RESULTADOS: COMO AS ESCOLAS FAZEM A POLÍTICA DE EFICIÊNCIA GERENCIAL EM PERNAMBUCO
Authors: LOURENCO EMANOEL , ARAGAO WILSON HONORATO
Published: November 2023

O texto analisa o Índice de Eficiência Gerencial (IEG), instrumento de responsabilização dos diretores escolares de Pernambuco e traz discussões com ênfase no Plano Estadual de Educação de Pernambuco (Meta 19), à luz do Plano Nacional de Educação - PNE. A metodologia baseia-se no Ciclo de Políticas (Ball, 2013) para analisar como as políticas são formuladas e atuadas em diferentes contextos. O IEG transforma a subjetividade dos diretores regulando-as pelo modelo de mercado e os sobrecarregando com uma nova burocracia virtual em prol de uma escola voltada para a competição, comparação e performatividade.
What is the Model of Sharia Marketing in Islamic Microfinance Institutions?
Authors: Shulthoni Muhammad , Hermawan Adinugraha Hendri , Rumiyati Eva , Imani Fathrezza , Achmad Dliyaudin
Published: November 2023

The rapid growth of BMT in Indonesia has not been matched by good marketing practices in the field. The main problems of BMT are weak funding and tight competition among BMTs. This study aims to describe an analysis of the concept, implementation, and strategy of sharia marketing in BTM Jawa Tengah. This research uses a qualitative descriptive approach using a case study type of research. The object of this research is BTM Jawa Tengah. The primary data for this study is information from interviews, with employees at BTM Jawa Tengah, namely the chairman, marketing department, and cashier. The secondary data of this research are in the form of official documents, books, journals, research results, and other data that are closely related to the subject of this research. Data collection procedures carried out are by way of observation, interviews, and documentation. Data analysis in this qualitative research uses descriptive analysis. The results of this study conclude that in general the concept of Sharia marketing in BTM Jawa Tengah is Sharia-driven or is driven by Sharia as a source of law that is oriented towards meeting the needs and desires of BTM Jawa Tengah consumers and creating value for them as long as it does not conflict with the Qur’an. and Hadith. The implementation of Sharia marketing at BTM Jawa Tengah uses the characteristics of Sharia marketing that uphold fairness, honesty, and transparency regarding margin setting and profit sharing and uses the nine ethical principles of Islamic marketing, which shows that the marketing strategy at BTM Jawa Tengah is appropriate and meets the sharia marketing perspective. The Sharia marketing strategy carried out by BTM Jawa Tengah is by determining product and service market segmentation. BTM Jawa Tengah carries out marketing activities according to the target market. This is done by looking at the needs of prospective customers. The final strategy is to apply to the position and apply traditional, conventional, and Sharia marketing in combination and simultaneously. The theoretical implications of this research can strengthen existing Sharia marketing theories. Practically, the findings of this study serve as a reference for BMT managers who wish to apply the Sharia marketing model.
Zeytin ve Zeytinyağında Bulunan Mayalar, Faydaları, Probiyotik Aktiviteleri ve Etki Mekanizmaları
Authors: CUMUR Pınar , KILIÇ KANAK Eda , ÖZTÜRK YILMAZ Suzan
Published: November 2023

Günümüzde probiyotiklerin kullanımı gözle görülür şekilde artmaktadır. Bağırsakta patojen mikroorganizmaların çoğalmasını engelleyerek daha sağlıklı bir flora ortamı oluşturmaları, bağırsak bariyerini güçlendirmeleri, inflamasyonu inhibe etmeleri gibi pek çok sebep, probiyotiklere olan ilgiyi gündemde tutmaya devam edecektir. Bu mikroorganizmaların insan sağlığına etkileri ve gıda üzerindeki yararlı etkileri düşünüldüğünde, yeni ve daha etkin probiyotik kaynak arayışları başlamıştır. Probiyotik mikroorganizmaların büyük çoğunluğu bakterilerden oluşmakla beraber, mayaların probiyotik özellikleri de günümüzde pek çok çalışma ile araştırılmaktadır. Bakterilerin antibiyotiklere karşı duyarlı olabilmeleri, toksin üretebilmeleri ve patojenite gösterebilmeleri gibi etkileri sebebiyle, probiyotik seçiminde tercih mayalara yönelmiştir. Fermente gıdalarda lezzeti artırmaları, yeni fonksiyonel gıda gelişimine katkıları ve bunlara ek olarak ürünlerin raf ömrünü artırmaya yönelik küf ve patojen mikroorganizmalar üzerine biyolojik kontrol ajanı görevi görmeleri, mayaların gıda biyoteknolojisinde geleceğinin parlak olduğunu göstermektedir. Günümüzde kullanılan çoğu probiyotik, fermente gıdalardan ya da sağlıklı bir insanı kolonize eden mikroorganizmalardan elde edilir. Sofralık zeytin; gıda endüstrisinin en önemli fermente gıdalarından olması sebebi ile potansiyel probiyotik maya kaynağı olarak düşünülebilir. Taze üretilmiş sızma zeytinyağının da mayalar da dahil olmak üzere zengin bir mikrobiyota tarafından temsil edilen biyotik bir fraksiyon içerdiği gösterilmiştir. Bu derlemede, mayaların probiyotik özelliklerine, zeytin ve zeytinyağında bulunan mayalara ve bu mayaların probiyotik etki mekanizmalarına yer verilmiştir.
Türkiye Florası İçin Yeni Bir İstilacı Bitki Kaydı: Grindelia hirsutula Hook. & Arn.
Authors: SEFALI Abdurrahman , UZUN Kübra
Published: November 2023

Türkiye’de son yıllarda birçok istilacı bitki kaydı verilmiştir. Bunların bazıları tıbbi ve ekonomik öneme sahip olduğundan bahçe veya tarla kaçkını olarak değerlendirilmektedir. Bahçe kaçkını olduğu düşünülen ve tıbbi kullanımı (üst solunum yolları enfeksiyonlarının tedavisi) olan Grindelia hirsutula stilacı bir bitki olarak Kütahya ilimizde tespit edilmiştir. Bu istilacı bitki kaydı aynı zamanda ülkemiz florası için yeni bir cins kaydı (Grindelia) niteliğindedir. Bitkiye ait betimlemelerin yanı sıra fotoğraflar ve ayırt edici karakterler (papus kılçıkları, glandular tüyler ve yaprak özellikleri gibi) makalede sunulmuştur. Grindelia hirsutula’nın ülkemiz florasında yer alan Inula cinsinden farklılıkları belirlenmiştir. Bitkinin Kew Herbaryumu’nda bulunan isotip örneğine ait bilgilere ve dünya üzerindeki yayılışına yer verilmiştir.
Comparison of Ca-Based Commercial and Natural Catalysts Performance on Olive Pomace Pyrolysis Process
Authors: GÖKTEPELİ Gamze , YEL Esra
Published: November 2023

Physicochemical treatment was applied with 20 mg/L alum to the marble processing effluents as 5 minutes 200 rpm mixing, 25 minutes 15 rpm mixing and 60 minutes settling and marble sludge (MS) was produced. Catalytic performance of MS in olive pomace (OP) pyrolysis process was evaluated and compared to commercial Ca(OH)2 since it mainly comprises of different AAEMs (especially Ca and its forms such as CaCO3, CaO) functioned as catalyst. Catalytic pyrolysis was conducted at 600°C and 5°C/min heating rate with 5% and 10% catalyst (MS or Ca(OH)2) dosages. Although both catalysts had important effect on pyrolysis product yields, Ca(OH)2 was found as good alternative for higher gas production and MS was introduced as better option for the higher char production comparing to the conventional OP pyrolysis. Pyrolysis biochars produced with MS were in higher thermal strength than the biochars generated with Ca(OH)2. Moreover, biooils of OP+MS include different organic compounds, such as 9 heptadecanol, 1-eicosanol, ethyl linoleate, ethyl oleate, addition to the compounds observed in pyrolysis liquids of OP and OP+ Ca(OH)2. All detected organic components have diverse usage areas. Ca(OH)2 provided more decrement in the percentages of oxygenated compounds as compared to the MS. Consequently, it can be stated that MS can be used successfully as an alternative to Ca-based commercial catalyst in OP pyrolysis.
Tabakalı Çift Hidroksit Katalizörler Kullanılarak Peroksimonosülfat ve Hidrojen Peroksit Aktivasyonu ile Gıda Boyalarının Giderimi: Box-Behnken Tasarımı ile Reaksiyon Koşullarının Optimizasyonu
Authors: PALAS Burcu , ERSÖZ Gülin , ATALAY Süheyda
Published: November 2023

Bu çalışmada, çeşitli tabakalı çift hidroksit (TÇH) katalizörlerinin peroksimonosülfat ve hidrojen peroksit aktivasyonu performansları, model gıda boyası olarak seçilen tartrazinin sulu çözeltilerden uzaklaştırılmasında test edilmiştir. Cu-Fe-TÇH, Co-Fe-TÇH ve Ni-Fe-TÇH’nin peroksimonosülfat ve hidrojen peroksit varlığında katalitik aktiviteleri karşılaştırılmıştır. Farklı oksidanlar kullanılarak gerçekleştirilen katalizör tarama deneylerinde Co-Fe-TÇH ve peroksimonosülfat en uygun katalizör ve oksidan olarak belirlenmiştir. Katalizör yüklemesi, pH ve oksidan/boya molar oranının etkileşimli etkileri araştırılmış ve Box-Behnken Design ve tepki yüzeyi metodolojisi kullanılarak reaksiyon koşulları optimize edilmiştir. 2 g/L katalizör yüklemesi, pH 3 ve 11,36 oksidan/boya molar oranı olarak belirlenen optimum reaksiyon koşullarında %87.35 organik madde giderimi ve %97.47 renk giderimi elde edilmiştir.
Lignocellulosic Bioethanol Efficiency of Different Sweet Sorghum (Sorghum bicolor var. saccharatum (L.) Mohlenbr.) Genotypes in Şanlıurfa Ecological Conditions
Authors: EFENDİOĞLU ÇELİK Ayşegül , AKSOY Mine , DOK Mahmut , AYDIN Kadir , YÜCEL Celal
Published: November 2023

The use of products with high biomass yield per unit area as a renewable energy source, which are not consumed primarily for food purposes or can be used for multi-purposes, is of great importance in terms of food safety. For this purpose, sweet sorghum plant, which can grow in salty-alkaline soils, tolerant to drought and short-term floods, and has wide adaptability, has gained importance as a lignocellulosic bioethanol raw material in recent years. The aim of this study is to theoretically determine the lignocellulosic bioethanol yield of 21 different sweet sorghum (Sorghum bicolor var. saccharatum (L.) Mohlenbr.) genotypes grown under second crop conditions in the ecology of Şanlıurfa province, obtained from domestic and foreign sources. In the study, sweet sorghum pulp from plant sap was used as lignocellulosic bioethanol raw material. The cellulose and hemicellulose contents of the pulp were determined and the amount of lignocellulosic bioethanol that could be obtained per decare was calculated by using the bioethanol conversion rates. According to the data obtained, the highest yield was obtained from UNL-Hybrid-3 (805.5 L/da), Theis (766.5 L/da), Smith (698.1 L/da) genotypes. In order to solve problems such as increasing the octane of gasoline, reducing greenhouse gas emissions and gasoline imports, it is recommended that these three genotypes be cultivated and disseminated for lignocellulosic bioethanol production in Şanlıurfa ecological conditions.
Kadmiyum Klorür Toksisitesinin Karaciğer, Böbrek ve Pankreasta Neden Olduğu Hasarı Melatonin Önler mi?
Authors: ŞENSOY Erhan
Published: November 2023

Yedinci tehlikeli ağır metal olan Kadmiyum, insan sağlığı için temel risk faktörlerinden birisi olarak ifade edilebilir. Besinlerle veya suyla vücuda alınan Kadmiyum, doku ve organlarda birikerek patolojilere yol açar. Düzenleyici görevleri olan Melatonin, aynı zamanda antioksidan bir hormondur. Çalışmanın amacı, oral ve intraperitonal yolla CdCl2 verilen gebe farelerin karaciğer, böbrek ve pankreaslarında belirlenen patolojilerin önlenmesinde melatoninin koruyucu rolünün araştırılmasıdır. Sunulan çalışmada gebelik sürecinde Cd alımı arttığı için gebe fareler kullanıldı. 42 gebe fare ile yedi grup (n:6) oluşturuldu. Kontrol (I.) grubuna oral yolla serum fizyolojik verildi. II. gruba CdCl2, III. gruba Melatoin, IV. gruba CdCl2+Melatoin oral yolla verildi. V. gruba CdCl2, VI. gruba Melatoin, VII. gruba CdCl2+Melatoin intraperitonal yolla verildi. Her iki uygulama yönteminde CdCl2 için 2 mg/kg/bw, Melatonin için 3 mg /kg/bw kullanıldı. Rutin histolojik işlemler gerçekleştirilen karaciğer, böbrek ve pankreas dokuları Hematoksilen-Eozinle boyandı. Işık mikroskobu ve elektron mikroskobu kullanılarak karşılaştırma yapıldı. CdCl2 verilen grupların ortalama organ ağırlıklarında artış belirlenirken, CdCl2+Mel gruplarında ortalama organ ağırlıklarının azaldığı görüldü (p: 0.02). Uygulama gruplarında CdCl2 kaynaklı patolojiler belirlenirken, CdCl2+Mel verilen gruplarda patolojilerin azaldığı belirlendi. İyileşmenin en çok karaciğerde olduğu görüldü. Melatonin’in karaciğer, böbrek ve pankreasta görülen CdCl2 kaynaklı patolojilerin tedavisinde etkili olabileceği belirlendi. Gebelik döneminde kadmiyuma yoğun olarak maruz kalan kadınların, uyku düzenlerine dikkat etmeleri ve melatonin takviyesi almaları önerilir. Kadmiyum maruziyetine karşı melatoninin diğer organlardaki etkisinin belirlenmesi için uzun süreli çalışmalara ihtiyaç olduğu düşünülmektedir.