bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation of absorption, distribution, metabolism, and excretion of [14C]-rucaparib, a poly(ADP-ribose) polymerase inhibitor, in patients with advanced solid tumors
Authors: Liao Mingxiang , Watkins Simon , Nash Eileen , Isaacson Jeff , Etter Jeff , Beltman Jeri , Fan Rong , Shen Li , Mutlib Abdul , Kemeny Vendel , Pápai Zsuzsanna , van Tilburg Pascal , Xiao Jim J.
Published: June 2019

Rucaparib, a poly(ADP-ribose) polymerase inhibitor, is licensed for use in recurrent ovarian, fallopian tube, or primary peritoneal cancer. We characterized the absorption, distribution, metabolism, and elimination of rucaparib in 6 patients with advanced solid tumors following a single oral dose of [14C]-rucaparib 600 mg (≈140 μCi). Total radioactivity (TRA) in blood, plasma, urine, and feces was measured using liquid scintillation counting. Unchanged rucaparib concentrations in plasma were determined using validated liquid chromatography with tandem mass spectrometry. Maximum concentration (Cmax) of TRA and unchanged rucaparib in plasma was 880 ng Eq/mL and 428 ng/mL, respectively, at approximately 4 h post dose; terminal half-life was >25 h for both TRA and rucaparib. The plasma TRA-time profile was parallel to yet higher than that of rucaparib, suggesting the presence of metabolites in plasma. Mean blood:plasma ratio of radioactivity was 1.0 for Cmax and 0.8 for area under the concentration-time curve from time zero to infinity. Mean postdose recovery of TRA was 89.3% over 12 days (71.9% in feces; 17.4% in urine). Unchanged rucaparib and M324 (oxidative metabolite) were the major components in plasma, contributing to 64.0% and 18.6% of plasma radioactivity, respectively. Rucaparib and M324 were the major rucaparib-related components (each ≈7.6% of dose) in urine, whereas rucaparib was the predominant component (63.9% of dose) in feces. The high fecal recovery of unchanged rucaparib could be attributed to hepatic excretion and/or incomplete oral absorption. Overall, these data suggest that rucaparib is eliminated through multiple pathways, including metabolism and renal and biliary excretion.
Differential Information, Arbitrage, and Subjective Value
Authors: Greene Catherine
Published: June 2019

de Bruin et al. (in: Zalta (ed) The Stanford encyclopedia of philosophy, Stanford University, Stanford, 2018) write that it is a philosophically interesting question “whether there is such a thing as an “intrinsic” value of financial assets” noting that the calculation of any intrinsic price will depend, in part, on subjective elements. McCauley suggest that there are at least five different notions of the ‘true value’ of an asset in finance theory, and argues, consistent with de Bruin et al. that in many cases the calculation of such values “makes impossible information demands on our knowledge of future dividends and returns” (McCauley (Dynamics of markets-econophysics and finance, Cambridge University Press, Cambridge, 2004). This paper explores some of the subjective elements involved in calculating the intrinsic value of an asset, and their implications for the Law of One Price. The Law of One Price states that investors should not pay different prices for the same investment. Consequently, the existence, and persistence, of arbitrage opportunities is often attributed to investor irrationality. However, if subjectivity is involved in the calculation of intrinsic value then two investors can, rationally, disagree about the value of a security. This implies that arbitrage opportunities may not always be instances of irrationality, or genuine mispricing, but reflect different investor’s perceptions of the security. In economics, value is taken to be subjective, and Postigo (Axiomathes 27:591–576, 2017) describes how goods have value because of the role they play in the satisfaction of our needs. By applying this to finance, this paper will argue that a security can play a number of roles in a portfolio, depending on an investors’ strategy. Given these different roles, different investors will be working with different data in their assessment of intrinsic value. In order to establish that an arbitrage opportunity exists it is therefore necessary to understand what information is relevant to pricing the investment in different locations, or markets. It may, in fact, be the case that the same security can trade at different prices because different investors do not see it as the ‘same thing’ at all. This analysis can also be used to throw doubt on the emphasis that fundamental analysis receives in discussions of rationality.
Elevated lysine crotonylation and succinylation in the brains of BTBR mice
Authors: Wang Min , Chang Qiaoqiao , Yang Hua , Liu Yongfeng , Wang Chunfang , Hu Fengyun , Wei Hongen , Li Rongshan
Published: June 2019

The BTBR T + Itpr3tf/J (BTBR) mouse has developmental disorders in the central nervous system and many aberrant neuroanatomical structures. However, identification of the pathological mechanisms underlying these abnormal neuroanatomical structures in the brains of BTBR mice is still lacking. Posttranslational modifications (PTMs) are known to be involved in the regulation of diverse cellular processes, and evidence shows that some types of PTMs are associated with the development of the central nervous system. In this study, we detected four novel PTMs in the cerebral cortex of BTBR mice as compared to C57BL/6 J (B6) mice using western blotting. Results revealed that lysine crotonylation and succinylation were elevated in the cerebral cortex of BTBR mice compared to levels in B6 mice. We speculate that elevated profiles of lysine crotonylation and succinylation may be involved in mechanisms related to neuroanatomical abnormalities in cerebral cortex of BTBR mice.
The Darwinian Revolution
Authors: Ruse Michael
Published: June 2019

What is the Darwinian revolution and why is it important for philosophers? These are the questions tackled in this Element. In four sections, the topics covered are the story of the revolution, the question of whether it really was a revolution, the nature of the revolution, and the implications for philosophy, both epistemology and ethics.
A Cross-Cultural Examination of the Experiences in Close Relationships — Revised — General Short Form (ECR-R-GSF) in an Australian and a Chinese Sample
Authors: Hao Jichun , Chan Raymond C.K. , Wilkinson Ross B.
Published: June 2019

Attachment dimensions refer to how interpersonal emotion regulation strategies are utilised and have a profound impact in adulthood. Its measurement has attracted a large amount of research attention. The Experiences in Close Relationships — Revised (ECR-R) Questionnaire is one of the most widely used and researched self-report questionnaires to measure romantic attachment anxiety and avoidance in multiple language groups, despite inconsistent evidence regarding its factorial structure. The 20-item Experiences in Close Relationships — Revised — General Short Form (ECR-R-GSF) was developed based on the ECR-R to measure attachment experiences in all relationships (not just romantic ones) in an English-speaking sample. However, no short form of the ECR-R is available for the Chinese population. In order to cross-validate the first Chinese version of the ECR-R-GSF, specifically the proposed two-factor structure, against the English version, an Australian university student sample (n = 426) and a Chinese university student sample from China (n = 626) were recruited. The Anxiety and Avoidance scales were found to have good internal reliability in both samples. However, the proposed two-factor model only provided an acceptable fit even after adding modifications in the Australian sample, and the fit was not satisfactory in the Chinese sample. Multigroup confirmatory factor analysis (CFA) indicated that partial metric but not scalar invariance was achieved across cultures. Implications for relationship and cross-cultural research and practice were discussed.
The Language of a Faithful Translator: On Canonising the Mandarin Union Version and Translating The Shack, a Contemporary Bestseller
Authors: LIU YA-CHUN
Published: June 2019

This article explores the continuing linguistic impact of the Mandarin Union Version by investigating and contrasting two Chinese translations of William Paul Young's global bestseller The Shack (2007): the Traditional Chinese version Xiaowu (《小屋》, 2009) and the Simplified Chinese version Pengwu (《棚屋》, 2010). Ever since its publication, the Mandarin Union Version has served as the predominant Bible within Mandarin-speaking Protestant communities across the world. This has brought about the standardisation of terminology in Chinese Protestantism. The Shack, though widely marked as a Christian novel, is also known for its unconventional fictional representations of Christianity that some Christians think depart from orthodoxy. Both Xiaowu and Pengwu were published by non-Christian publishing houses for a general readership. However, Xiaowu, translated by a Christian, exhibits a significant number of phrases that specifically belong to Chinese Christian terminology shaped by the Mandarin Union Version. Pengwu is a contrast in this regard. By comparing extracts from these two Chinese versions, this article highlights how far the Mandarin Union Version has contributed to the formation of the linguistic repertoire of Mandarin-speaking Christian translators as well as linguistic norms for translated Christian-themed texts into Chinese.
Using Machine Learning for Prediction of Saturated Hydraulic Conductivity and Its Sensitivity to Soil Structural Perturbations
Authors: Araya Samuel N. , Ghezzehei Teamrat A.
Published: June 2019

Saturated hydraulic conductivity (Ks) is a fundamental soil property that regulates the fate of water in soils. Its measurement, however, is cumbersome and instead pedotransfer functions (PTFs) are routinely used to estimate it. Despite much progress over the years, the performance of current generic PTFs estimating Ks remains poor. Using machine learning, high‐performance computing, and a large database of over 18,000 soils, we developed new PTFs to predict Ks. We compared the performances of four machine learning algorithms and different predictor sets. We evaluated the relative importance of soil properties in explaining Ks. PTF models based on boosted regression tree algorithm produced the best models with root‐mean‐squared log‐transformed error in ranges of 0.4 to 0.3 (log10(cm/day)). The 10th percentile particle diameter (d10) was found to be the most important predictor followed by clay content, bulk density (ρb), and organic carbon content (C). The sensitivity of Ks to soil structure was investigated using ρb and C as proxies for soil structure. An inverse relationship was observed between ρb and Ks, with the highest sensitivity at around 1.8 g/cm3 for most textural classes. Soil C showed a complex relationship with Ks with an overall positive relation for fine‐textured and midtextured soils but an inverse relation for coarse‐textured soils. This study sought to maximize the extraction of information from a large database to develop generic machine learning‐based PTFs for estimating Ks. Models developed here have been made publicly available and can be readily used to predict Ks.
Rate-and-state friction explains glacier surge propagation
Authors: Thøgersen Kjetil , Gilbert Adrien , Schuler Thomas Vikhamar , Malthe-Sørenssen Anders
Published: June 2019

The incomplete understanding of glacier dynamics is a major source of uncertainty in assessments of sea-level rise from land-based ice. Through increased ice discharge into the oceans, accelerating glacier flow has the potential to considerably enhance expected sea-level change, well ahead of scenarios considered by the IPCC. Central in our incomplete understanding is the motion at the glacier bed, responsible for flow transients and instabilities involving switches from slow to fast flow. We introduce a rate-and-state framework for the transient evolution of basal shear stress, which we incorporate in glacier simulations. We demonstrate that a velocity-strengthening-weakening transition combined with a characteristic length scale for the opening of subglacial cavities is sufficient to reproduce several previously unexplained features of glacier surges. The rate-and-state framework opens for new ways to analyze, understand and predict transient glacier dynamics as well as to assess the stability of glaciers and ice caps.
Intrinsic enzymatic properties modulate the self-propulsion of micromotors
Authors: Arqué Xavier , Romero-Rivera Adrian , Feixas Ferran , Patiño Tania , Osuna Sílvia , Sánchez Samuel
Published: June 2019

Bio-catalytic micro- and nanomotors self-propel by the enzymatic conversion of substrates into products. Despite the advances in the field, the fundamental aspects underlying enzyme-powered self-propulsion have rarely been studied. In this work, we select four enzymes (urease, acetylcholinesterase, glucose oxidase, and aldolase) to be attached on silica microcapsules and study how their turnover number and conformational dynamics affect the self-propulsion, combining both an experimental and molecular dynamics simulations approach. Urease and acetylcholinesterase, the enzymes with higher catalytic rates, are the only enzymes capable of producing active motion. Molecular dynamics simulations reveal that urease and acetylcholinesterase display the highest degree of flexibility near the active site, which could play a role on the catalytic process. We experimentally assess this hypothesis for urease micromotors through competitive inhibition (acetohydroxamic acid) and increasing enzyme rigidity (β-mercaptoethanol). We conclude that the conformational changes are a precondition of urease catalysis, which is essential to generate self-propulsion.
Author Correction: Microbially induced potassium enrichment in Paleoproterozoic shales and implications for reverse weathering on early Earth
Authors: Aubineau Jérémie , El Albani Abderrazak , Bekker Andrey , Somogyi Andrea , Bankole Olabode M. , Macchiarelli Roberto , Meunier Alain , Riboulleau Armelle , Reynaud Jean-Yves , Konhauser Kurt O.
Published: June 2019

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Author Correction: New insights into mitral heart valve prolapse after chordae rupture through fluid–structure interaction computational modeling
Authors: Caballero Andrés , Mao Wenbin , McKay Raymond , Primiano Charles , Hashim Sabet , Sun Wei
Published: June 2019

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
Abnormal leaf development of rpt5a mutant under zinc deficiency reveals important role of DNA damage alleviation for normal leaf development
Authors: Sotta Naoyuki , Sakamoto Takuya , Matsunaga Sachihiro , Fujiwara Toru
Published: June 2019

Leaf development in plants, including dorsoventral (adaxial–abaxial) patterning, is tightly regulated. The involvement of several subunits of the 26S proteasome in adaxial–abaxial polarity establishment has been reported. In the present study, we revealed that inArabidopsis thaliana, a mutation inRPT5A, a subunit of 26S proteasome, causes abnormally narrow true leaves under zinc deficiency. mRNA accumulations of DNA damage marker genes in leaves were elevated by zinc deficiency.PARP2, a single-strand break (SSB) inducible gene, was more strongly induced by zinc deficiency inrpt5amutants compared with the wild type. A comet assay indicated that SSB is enhanced in mutants grown under the zinc deficiency condition. These results suggest that SSB accumulation is accompanied by abnormal leaf development. To test if DNA damage is a sole cause of abnormal leaf development, we treated the wild type grown under normal zinc conditions with zeocin, a DNA damage-inducing reagent, and found that narrow leaves developed, suggesting that DNA damage is sufficient to induce the development of abnormally narrow leaves. Taken together with the observation of the abnormal leaf morphology of our mutant plant under zinc deficiency, we demonstrated that the alleviation of DNA damage is important for normal leaf development.
Genotypic Characterization of Emerging Avian Reovirus Genetic Variants in California
Authors: Egaña-Labrin S. , Hauck R. , Figueroa A. , Stoute S. , Shivaprasad H. L. , Crispo M. , Corsiglia C. , Zhou H. , Kern C. , Crossley B. , Gallardo R. A.
Published: June 2019

This study focuses on virus isolation of avian reoviruses from a tenosynovitis outbreak between September 2015 and June 2018, the molecular characterization of selected isolates based on partial S1 gene sequences, and the full genome characterization of seven isolates. A total of 265 reoviruses were detected and isolated, 83.3% from tendons and joints, 12.3% from the heart and 3.7% from intestines. Eighty five out of the 150 (56.6%) selected viruses for sequencing and characterization were successfully detected, amplified and sequenced. The characterized reoviruses grouped in six distinct genotypic clusters (GC1 to GC6). The most represented clusters were GC1 (51.8%) and GC6 (24.7%), followed by GC2 (12.9%) and GC4 (7.2%), and less frequent GC5 (2.4%) and GC3 (1.2%). A shift on cluster representation throughout time occurred. A reduction of GC1 and an increase of GC6 classified strains was noticed. The highest homologies to S1133 reovirus strain were detected in GC1 (~77%) while GC2 to GC6 homologies ranged between 58.5 and 54.1%. Over time these homologies have been maintained. Seven selected isolates were full genome sequenced. Results indicated that the L3, S1 and M2 genes, coding for proteins located in the virus capsid accounted for most of the variability of these viruses. The information generated in the present study helps the understanding of the epidemiology of reoviruses in California. In addition, provides insights on how other genes that are not commonly studied add variability to the reovirus genome.
Cardiovascular Magnetic Resonance-Based Three-Dimensional Structural Modeling and Heterogeneous Tissue Channel Detection in Ventricular Arrhythmia
Authors: Jang Jihye , Hwang Hye-Jin , Tschabrunn Cory M. , Whitaker John , Menze Bjoern , Anter Elad , Nezafat Reza
Published: June 2019

Geometrical structure of the myocardium plays an important role in understanding the generation of arrhythmias. In particular, a heterogeneous tissue (HT) channel defined in cardiovascular magnetic resonance (CMR) has been suggested to correlate with conduction channels defined in electroanatomic mapping in ventricular tachycardia (VT). Despite the potential of CMR for characterization of the arrhythmogenic substrate, there is currently no standard approach to identify potential conduction channels. Therefore, we sought to develop a workflow to identify HT channel based on the structural 3D modeling of the viable myocardium within areas of dense scar. We focus on macro-level HT channel detection in this work. The proposed technique was tested in high-resolution ex-vivo CMR images in 20 post-infarct swine models who underwent an electrophysiology study for VT inducibility. HT channel was detected in 15 animals with inducible VT, whereas it was only detected in 1 out of 5 animal with non-inducible VT (P < 0.01, Fisher’s exact test). The HT channel detected in the non-inducible animal was shorter than those detected in animals with inducible VTs (inducible-VT animals: 35 ± 14 mm vs. non-inducible VT animal: 9.94 mm). Electrophysiology study and histopathological analyses validated the detected HT channels. The proposed technique may provide new insights for understanding the macro-level VT mechanism.
Structural and Photoelectric Properties of Epitaxially Grown Vanadium Dioxide Thin Films on c-Plane Sapphire and Titanium Dioxide
Authors: Creeden Jason A. , Madaras Scott E. , Beringer Douglas B. , Beebe Melissa R. , Novikova Irina , Lukaszew R. Ale
Published: June 2019

Vanadium dioxide (VO2) is one of the most extensively studied materials in the strongly correlated electron family capable of sustaining an insulator-to-metal transition. Here we present our studies of high-quality thin films of epitaxially grown VO2 on c-Al2O3(0001) and TiO2(001) via reactive DC pulsed magnetron sputtering. We present the structural transition probed via Reflection High Energy Electron Diffraction (RHEED) for the first time and we correlate the surface microstructure measurements with simulations before, during, and after the thermally induced transition. We also study the photoelectric conversion of VO2 on TiO2(001) and c-Al2O3(0001) under 405 nm light and demonstrate up to a 2000% increase in quantum efficiency as the power of the light is varied for VO2 on TiO2(001).
A model of the entrance pupil of the human eye
Authors: Aguirre Geoffrey K.
Published: June 2019

The aperture stop of the iris is subject to refraction by the cornea, and thus an outside observer sees a virtual image: the “entrance pupil” of the eye. When viewed off-axis, the entrance pupil has an elliptical form. The precise appearance of the entrance pupil is a consequence of the anatomical and optical properties of the eye, and the relative positions of the eye and the observer. This paper presents a ray traced model eye that provides the parameters of the entrance pupil ellipse for an observer at an arbitrary location. The model is able to reproduce empirical measurements of the shape of the entrance pupil with good accuracy. I demonstrate that accurate specification of the entrance pupil of a stationary eye requires modeling of corneal refraction, the misalignment of the visual and optical axes, and the non-circularity of the aperture stop. The model, including a three-dimensional ray tracing function through quadric surfaces, is implemented in open-source MATLAB code.
Enzyme activity and structural features of three single-domain phloem cyclophilins from Brassica napus
Authors: Hanhart Patrizia , Falke Sven , Garbe Marcel , Rose Victoria , Thieß Melanie , Betzel Christian , Kehr Julia
Published: June 2019

Cyclophilins (CYPs) are a group of ubiquitous prolyl cis/trans isomerases (PPIases). It was shown that plants possess the most diverse CYP families and that these are abundant in the phloem long-distance translocation stream. Since phloem exudate showed PPIase activity, three single-domain CYPs that occur in phloem samples from Brassica napus were characterised on functional and structural levels. It could be shown that they exhibit isomerase activity and that this activity is controlled by a redox regulation mechanism, which has been postulated for divergent CYPs. The structure determination by small-angle X-ray scattering experiments revealed a conserved globular shape. In addition, the high-resolution crystal structure of BnCYP19-1 was resolved and refined to 2.0 Å resolution, and the active sites of related CYPs as well as substrate binding were modelled. The obtained data and results support the hypothesis that single domain phloem CYPs are active phloem PPIases that may function as chaperones.
Sustainability of Green Synthetic Processes and Procedures
Authors: Horváth István T. , Cséfalvay Edit
Published: June 2019

Although the ecological footprint was perhaps the first green metric, the atom economy and E-factor have become the key metrics of green chemistry by providing the mass balance of chemical reactions and processes at the molecular level. Sustainability was poorly defined originally, since the key requisite to accurately forecast the needs of future generations remains difficult to pinpoint. Consequently, sustainability was replaced with suitability by many stake holders, as they had vested and/or conflicts of interests to label suitable developments sustainable. The sustainable development goals recently introduced by the United Nations seem to serve as a ‘roadmap to happiness’ instead of metrics. A simple and independent definition of sustainability was recently provided: Nature's resources, including energy, should be used at a rate at which they can be replaced naturally, and the generation of wastes cannot be faster than the rate of their remediation by Nature. The ethanol equivalent, the sustainability values of resource replacement and fate of waste, and the sustainability indicator have been recently defined to measure the sustainability of biomass-based carbon-chemicals and renewable energy. The production of ethylene, propylene, toluene, xylenes, styrene, and ethylene oxides cannot be sustainable due to the limited amount of bioethanol. The required volume of corn and the corresponding size of land are only enough to replace one sixth of fossil resources in the USA, EU, and China, and practically insufficient in Canada and the Russian Federation. Until the utilization of electricity becomes practical and economical in aviation, biomass-based liquid fuels are the sustainable alternative.
One-pot Organic Reactions
Authors: Zhang Wei
Published: June 2019

Reaction efficiency is an important aspect of green synthesis. One-pot reactions, including cascade reactions, stepwise reactions, and multicomponent reactions, offer intrinsic advantages of simple operation procedures, short reaction times, and reduced amount of waste. This chapter introduces the concept of one-pot reactions and demonstrates their efficiency in the design and synthesis of functionalized molecules.
Flow Chemistry in Drug Discovery
Authors: Alcazar J. , de la Hoz A. , Díaz-Ortiz A.
Published: June 2019

This chapter provides an overview of the use of flow chemistry in drug discovery settings, first introducing the green characteristics of flow chemistry and then describing the drug discovery process and how both worlds can be matched. Examples are provided that cover all stages of drug discovery, from the identification of the initial hits to the preparation of Active Pharmaceutical Ingredients. The automation and integration of new green technologies are also reported.
Photoelectrochemical immunoassay of aflatoxin B1 in foodstuff based on amorphous TiO2 and CsPbBr3 perovskite nanocrystals
Authors: Su Lingshan , Tong Ping , Zhang Lijia , Luo Zhongbin , Fu Caili , Tang Dianping , Zhang Yuyu
Published: June 2019

A split-type photoelectrochemical immunoassay was designed to detect AFB1 in foodstuffs using amorphous TiO2 and CsPbBr3 perovskite nanocrystals.
Highly sensitive and selective colorimetric determination ofStaphylococcus aureus viachicken anti-protein A IgY antibody
Authors: Zhang Yun , Tan Wenqing , Zhang Lin , Shi Shuyou , Niu Yuna , Yang Xue , Qiao Jinjuan , Wang Hui
Published: June 2019

Utilization of chicken anti-protein A IgY as an antibody pair for sensitive and selective detection ofS. aureus.
A halogen-bonding-catalysed Nazarov cyclisation reaction
Authors: Dreger Alexander , Wonner Patrick , Engelage Elric , Walter Sebastian M. , Stoll Raphael , Huber Stefan M.
Published: June 2019

Various neutral, mono- and dicationic halogen bond donors were screened for their ability to act as catalysts in a Nazarov cyclisation reaction.
Impurities in graphene/PLA 3D-printing filaments dramatically influence the electrochemical properties of the devices
Authors: Browne Michelle P. , Pumera Martin
Published: June 2019

Commercial 3D printing filament, extensively used for electrochemical applications, contains metal impurities which alters the electrochemical response. Characterisation needed always.
Tailoring the physicochemical properties of solution-processed transition metal dichalcogenides via molecular approaches
Authors: Ippolito Stefano , Ciesielski Artur , Samorì Paolo
Published: June 2019

In this Feature Article we highlight the tremendous progress in solution-processed transition metal dichalcogenides and the molecular approaches employed to finely tune their physicochemical properties.
Monomeric thorium dihydrido complexes: versatile precursors to actinide metallacycles
Authors: Qin Guorui , Wang Yang , Shi Xianghui , Del Rosal Iker , Maron Laurent , Cheng Jianhua
Published: June 2019

The monomeric actinide dihydrido complex [(CpAr*)(Cp*)ThH2(THF)] (2) and actinide metallacyclopentyne [(CpAr*)(Cp*)Th(PhCH–CC–CHPh)] (4) were obtained for the first time.
Amyloid fibrils from organic solutions of an amphiphilic dipeptide
Authors: Casanovas Jordi , Mayans Enric , Díaz Angélica , Gil Ana M. , Jiménez Ana I. , Cativiela Carlos , Puiggalí Jordi , Alemán Carlos
Published: June 2019

A diphenylalanine amphiphile blocked at the C-terminus with a fluorenylmethyl ester and stabilized at the N-terminus with a trifluoroacetate forms amyloid fibril networks in organic solvents.
Anchoring carbon nanotubes and post-hydroxylation treatment enhanced Ni nanofiber catalysts towards efficient hydrous hydrazine decomposition for effective hydrogen generation
Authors: Yang Pan , Yang Lijun , Gao Qiang , Luo Qiang , Zhao Xiaochong , Mai Xianmin , Fu Qinglong , Dong Mengyao , Wang Jingchuan , Hao Yawei , Yang Ruizhu , Lai Xinchun , Wu Shide , Shao Qian , Ding Tao , Lin Jing , Guo Zhanhu
Published: June 2019

CNTs and hydroxylation enhanced Ni nanofibers for decomposing hydrous hydrazine with a reduced activation energy down to 51.05 kJ mol−1.
Role of citrate in the formation of enamel-like calcium phosphate oriented nanorod arrays
Authors: Carella Francesca , Degli Esposti Lorenzo , Barreca Davide , Rizzi Gian Andrea , Martra Gianmario , Ivanchenko Pavlo , Escolano Casado Guillermo , Gomez Morales Jaime , Delgado Lòpez José Manuel , Tampieri Anna , Iafisco Michele
Published: June 2019

The effect of citrate on the formation of oriented fluoride doped hydroxyapatite nanorods grown on an amorphous calcium phosphate substrate was investigated.
The sapphire substrate pretreatment effects on high-temperature annealed AlN templates in deep ultraviolet light emitting diodes
Authors: Wang M. X. , Xu F. J. , Wang J. M. , Xie N. , Sun Y. H. , Liu B. Y. , Lang J. , Zhang N. , Ge W. K. , Kang X. N. , Qin Z. X. , Yang X. L. , Wang X. Q. , Shen B.
Published: June 2019

Evolution of crystalline quality of AlN via high-temperature (HT) annealing induced by different sapphire pretreatments is investigated.
Microwave-assisted synthesis of porous organic cages CC3 and CC2
Authors: Lucero Jolie , Osuna Carla , Crawford James M. , Carreon Moises A.
Published: June 2019

The microwave synthesis of two prototypical porous organic cages, denoted as CC3 and CC2 is demonstrated.
Computational prediction of promising pyrazine and bipyridine analogues of a fluorinated MOF platform, MFN-Ni-L (M = SI/AL; N = SIX/FIVE; L = pyr/bipyr), for CO2 capture under pre-humidified conditions
Authors: S. Pillai Renjith , Suresh Cherumuttathu H.
Published: June 2019

The CO2 separation performance has been explored under dry and pre-humidified conditions for the fluorinated-MOFs with/without a coordinatively unsaturated sites (CUS), Al vs. Si, and organic linkers 1,4-pyrazine and 4,4′-bipyridine.
Single-layer structures of a100- and b010-Gallenene: a tight-binding approach
Authors: Nakhaee M. , Yagmurcukardes M. , Ketabi S. A. , Peeters F. M.
Published: June 2019

Using the simplified linear combination of atomic orbitals (LCAO) method in combination with ab initio calculations, we construct a tight-binding (TB) model for two different crystal structures of monolayer gallium: a100- and b010-Gallenene.
Investigating the asymmetry in the EDL response of C60/graphene supercapacitors
Authors: Fileti Eudes Eterno , Colherinhas Guilherme
Published: June 2019

Molecular dynamics simulations were employed to model C60/graphene composite electrodes that can expand the effective area and performance of supercapacitors.
Unravelling the modus-operandi of chromenylium-cyanine fluorescent probes: a case study
Authors: Flores-Cruz Ricardo , López-Arteaga Rafael , Ramírez-Vidal Lizbeth , López-Casillas Fernando , Jiménez-Sánchez Arturo
Published: June 2019

This versatile probe enables bioanalytical analysis of different species including singlet oxygen 1O2, under in vitro or in vivo conditions.
Quantum proton tunneling in multi-electron/-proton transfer electrode processes
Authors: Sakaushi Ken
Published: June 2019

Quantum proton tunneling in multi-electron/-proton transfer electrode processes were investigated in order to understand their possible microscopic mechanisms.
New flexible molecular probes bearing dansyl and TEMPO moieties for host–guest interactions in solution and gels
Authors: Mocanu Sorin , Matei Iulia , Leonties Anca , Tecuceanu Victorita , Hanganu Anamaria , Minea Zamfirica , Stancu Alina , Popescu Elena Irina , Ionita Gabriela
Published: June 2019

Host–guest interactions in functionalised alginate gels are evidenced by EPR and fluorescence spectra.
In vitrocytotoxicity and catalytic evaluation of dioxidovanadium(v) complexes in an azohydrazone ligand environment
Authors: Mohanty Monalisa , Maurya Shailendra K. , Banerjee Atanu , Patra Sushree Aradhana , Maurya Mannar R. , Crochet Aurélien , Brzezinski Krzysztof , Dinda Rupam
Published: June 2019

Synthesis, characterization,in vitrocytotoxicity and catalytic potential of the dioxidovanadium(v) complexes of azohydrazones.
Straightforward synthesis of photoactive chalcogen functionalized benzimidazo[1,2-a]quinolines
Authors: da Silva Rodrigo Borges , Lange Coelho Felipe , Rodembusch Fabiano Severo , Schwab Ricardo Samuel , Schneider Juliana Maria Forain Miolo , da Silveira Rampon Daniel , Schneider Paulo Henrique
Published: June 2019

A series of new organochalcogen derivatives of benzimidazo[1,2-a]quinolines were synthesized. Both sulfur and selenium derivatives presented similar photophysical properties with absorption in the UV region and fluorescence emission in the violet-blue.
Few-layered mesoporous graphitic carbon nitride: a graphene analogue with high capacitance properties
Authors: Idris Mustapha Balarabe , Devaraj S.
Published: June 2019

Exfoliation of multi-layered MGCN into few-layered MGCN results in 50% enhancement in the specific capacitance value.
Catalytic performance of a phosphorus-modified H-IM-5@meso-SiO2 composite in the alkylation of toluene with methanol
Authors: Yi Dezhi , Meng Xuan , Liu Naiwang , Shi Li
Published: June 2019

A phosphorus-modified H-IM-5@meso-SiO2 was synthesized, and its acidity and pore channels were modified to enhance the selectivity of the target product.
Mechanistic insights into CO2 cycloaddition of styrene oxide on paddle-wheel metal clusters: a theoretical study
Authors: Sirijaraensre Jakkapan
Published: June 2019

The reaction mechanisms for the CO2 cycloaddition of styrene oxide catalyzed by M–BTC clusters have been systematically elucidated by means of the M06-L functional.
Carbon dioxide utilization in the efficient synthesis of carbamates by deep eutectic solvents (DES) as green and attractive solvent/catalyst systems
Authors: Dindarloo Inaloo Iman , Majnooni Sahar
Published: June 2019

Deep eutectic solvents as a green solvent/catalyst system for directly synthesizing carbamates from amines, CO2and alkyl halides.
Formation of CoNi2S4nanofibers with 3D hierarchical pompom-like structure for high-rate electrochemical capacitors
Authors: Yuan Jingjing , Yao Dachuan , Zheng Xiaoke , Liang Jianxing , Jiang Ling , Che Jianfei , He Guangyu , Chen Haiqun
Published: June 2019

Pompom-like 3D hierarchical structured CoNi2S4nanofibers are obtainedviaa two-step anion exchange route, exhibiting good high-rate performance.
Core–shell vs. multi-shell formation in nanoalloy evolution from disordered configurations
Authors: Nelli Diana , Ferrando Riccardo
Published: June 2019

The evolution towards equilibrium of AuCo, AgNi and AgCu nanoparticles takes place through a sequence of complex transformations.
Correction: Laser printing of optically resonant hollow crystalline carbon nanostructures from 1D and 2D metal–organic frameworks
Authors: Mingabudinova Leila R. , Zalogina Anastasiia S. , Krasilin Andrei A. , Petrova Margarita I. , Trofimov Pavel , Mezenov Yuri A. , Ubyivovk Evgeniy V. , Lönnecke Peter , Nominé Alexandre , Ghanbaja Jaafar , Belmonte Thierry , Milichko Valentin A.
Published: June 2019

Correction for ‘Laser printing of optically resonant hollow crystalline carbon nanostructures from 1D and 2D metal–organic frameworks’ by Leila R. Mingabudinova et al., Nanoscale, 2019, 11, 10155–10159.
Modeling study of the heat of absorption and solid precipitation for CO2capture by chilled ammonia
Authors: Zhou Qiang , Liu Lan , Croiset Eric , Tan Zhongchao , Liu Qingcai , Yang Jian
Published: June 2019

Prediction of (a) solution speciation change and (b) heat of CO2absorption in the chilled ammonia process (CAP).
Supramolecular gels from sugar-linked triazole amphiphiles for drug entrapment and release for topical application
Authors: Sharma Komal , Joseph Jojo P. , Sahu Adarsh , Yadav Narender , Tyagi Mohit , Singh Ashmeet , Pal Asish , Kartha K. P. Ravindranathan
Published: June 2019

Spontaneous formation of hierarchical supramolecular gels show solvent dictated self-assembly and spatio-temporal positioning of drug molecules in the network accounting for differential release profiles for topical application.
Coated silver nanoparticles: synthesis, cytotoxicity, and optical properties
Authors: Fahmy Heba Mohamed , Mosleh Ayaat Mahmoud , Elghany Aya Abd , Shams-Eldin Engy , Abu Serea Esraa Samy , Ali Somaia Ashour , Shalan Ahmed Esmail
Published: June 2019

Coated silver nanoparticles (AgNPs) have recently become a topic of interest due to the fact that they have several applications such as in electronic, antimicrobial, industrial, optical, and medical fields as biosensors and drug delivery systems.
Heterogeneous Rh and Rh/Ag bimetallic nanoparticle catalysts immobilized on chiral polymers
Authors: Min Hyemin , Miyamura Hiroyuki , Yasukawa Tomohiro , Kobayashi Shū
Published: June 2019

We have developed novel heterogeneous chiral Rh and Rh/Ag NP catalysts immobilized on a chiral diene-containing polymer. The catalysts showed high activity in asymmetric reactions in both batch and flow systems.
Scalable nanomanufacturing of inkjet-printed wearable energy storage devices
Authors: Huang Tao-Tse , Wu Wenzhuo
Published: June 2019

The nanomaterial-based wearable energy storage devices will usher in exciting opportunities in emerging technologies such as consumer electronics, pervasive computing, human–machine interface, robotics, and the Internet of Things.
Gas sensors based on assembled porous graphene multilayer frameworks for DMMP detection
Authors: Wang Yanyan , Yang Ming , Liu Weixiao , Dong Lei , Chen Da , Peng Changsi
Published: June 2019

In this work, a structure of assembled porous graphene multilayer frameworks was demonstrated to endow the resultant sensing devices with batch uniformity, good response, sensitivity, and selectivity.
Slow relaxation of magnetization in unprecedented Cu–Ln-Rad hetero-tri-spin chains constructed from multidentate nitronyl nitroxide
Authors: Sun Juan , Sun Zan , Wang Kang , Xi Lu , Ma Yue , Li Licun
Published: June 2019

Unprecedented Cu–Ln heterometallic chains derived from poly-dentate nitronyl nitroxides are reported. A Tb complex shows slow magnetic relaxation, while a Dy derivative displays interesting two-step relaxations of magnetization.
Non-equivalent Mn4+ doping into A2NaScF6 (A = K, Rb, Cs) hosts toward short fluorescence lifetime for backlight display application
Authors: Zhou Y. Y. , Song E. H. , Brik M. G. , Wang Y. J. , Hu T. , Xia Z. G. , Zhang Q. Y.
Published: June 2019

Non-equivalent Mn4+-doped A2NaScF6 (A = K, Rb, Cs) phosphors with short fluorescence lifetime for fast-response backlight displays were fabricated in this study.
Biochemical features of primary cells from a pediatric patient with a gain-of-function ODC1 genetic mutation
Authors: Schultz Chad R. , Bupp Caleb P. , Rajasekaran Surender , Bachmann André S.
Published: June 2019

We recently described a new autosomal dominant genetic disorder in a pediatric patient caused by a heterozygous de novo mutation in the ornithine decarboxylase 1 (ODC1) gene. The new genetic disorder is characterized by global developmental delay, alopecia, overgrowth, and dysmorphic features. We hypothesized that this new mutation (c.1342 A>T) leads to a C-terminal truncation variant of the ODC protein that is resistant to normal proteasomal degradation, leading to putrescine accumulation in cells. ODC (E.C. 4.1.1.17) is a rate-limiting enzyme in the biosynthesis of polyamines (putrescine, spermidine, and spermine) that plays a crucial role during embryogenesis, organogenesis, and tumorigenesis. In this study, we show that primary dermal fibroblasts derived from a skin biopsy of a 3-year-old patient contain large amounts of ODC protein and putrescine compared with primary dermal (neonatal and adult) fibroblast control cells. Importantly, the accumulated ODC protein variant remained functionally active as we detected exceptionally high ODC enzyme activity in both primary dermal fibroblasts (12–17-fold of controls) and red blood cells (RBCs) (125–137-fold of controls), using a specific 14C radioactive ODC activity assay. Exposure of primary dermal fibroblasts to ODC inhibitor α-difluoromethylornithine (DFMO) reduced the ODC activity and putrescine to levels observed in controls without adversely affecting cell morphology or inducing cell death. In conclusion, our patient and potentially other patients that carry a similar ODC1 gain-of-function mutation might benefit from treatment with DFMO, a drug with a good safety profile, to suppress the exceptionally high ODC activity and putrescine levels in the body.
Riboswitches: choosing the best platform
Authors: Arnvig Kristine B.
Published: June 2019

Riboswitch discovery and characterisation have come a long way since the term was first coined almost two decades ago. Riboswitches themselves are likely derived from ancient ligand-binding transcripts, which have evolved into sophisticated genetic control elements that are widespread in prokaryotes. Riboswitches are associated with a multitude of cellular processes including biosynthetic pathways, transport mechanisms and stress responses leading to an ever-increasing appreciation for an in-depth understanding of their triggers and functions in order to address physiological and regulatory questions. The majority of riboswitches exert their control via transcriptional or translational expression platforms depending on their genetic context. It remains, however, to be determined precisely why one platform is favoured over another. Is this a question of the layout of the gene expression machinery, ligand availability, the degree of control required, serendipity or various combinations of these? With this review, rather than providing answers, I am hoping to plant a seed for further scientific discussions about this puzzle.
Compact ultra‐wideband bandstop filter using capacitive loads
Authors: Liu Baoguang , Lyu Yun‐Peng , Zhu Lei , Cheng Chonghu
Published: June 2019

A compact UWB band‐stop filter (BSF) using capacitive loads is proposed. In contrast to its traditional counterparts, this proposed BSF only consists of two capacitors and a short‐ended coupled line (C‐section). By introducing capacitors inside the C‐section and between two ports, respectively, cross‐coupling and source/load coupling are introduced to create up to four transmission zeros. Meanwhile, shunt capacitive effect of loaded capacitors can further reduce the length of C‐section. After working principle and design method of this proposed BSF are well‐illustrated, a prototype with 20 dB fractional bandwidth of 110% at 4.24 GHz is finally designed and fabricated. It occupies only 0.45λg × 0.061λg, where λg is the guided wavelength at the centre frequency.
5 GHz Band n79 wideband microacoustic filter using thin lithium niobate membrane
Authors: Turner P.J. , Garcia B. , Yantchev V. , Dyer G. , Yandrapalli S. , Villanueva L.G. , Hammond R.B. , Plessky V.
Published: June 2019

Microacoustic resonators made on suspended continuous membranes of LiNbO3 were recently shown to have very strong coupling and low losses at ≥5 GHz, suitable for high‐performance filter design. Employing these simple resonator structures, the authors have designed, fabricated, and measured a 4.7 GHz bandpass ladder‐type filter having 1 dB mid‐band loss and 600 MHz bandwidth to address the 5G Band n79 requirements. The filter is fabricated on a monolithic substrate using standard i‐line optical lithography and standard semiconductor processing methods for membrane release, starting with commercially available ion‐sliced wafers having 400 nm thickness crystalline LiNbO3 layers. The filter is well‐matched to a 50 Ω network and does not require external matching elements. Through accurate resonator engineering using our finite element method software filter design environment, the passband is spurious‐free, and the filter provides better‐than 30 dB rejection to the adjacent WiFi frequencies. This filter demonstrates the performance and scalable technology required for high‐volume manufacturing of microacoustic filters >3.5 GHz.
CMOS OOK modulator with fast envelope transient
Authors: Chang S.‐E. , Chen Y.‐J.E.
Published: June 2019

This Letter presents a 2 GHz 130 nm CMOS absorptive on–off keying (OOK) modulator. The loop matching technique is proposed to realise wideband matching such that fast modulation envelope transient can be achieved. The parallel LC network is adopted to reduce the impedance variation between the ON and OFF states of the modulator. The CMOS OOK modulator is capable of delivering the modulation data rate of 734 Mbps, leading to the data‐to‐carrier‐ratio of 36.7%.
Non‐linear disturbance observer‐based improved frequency and tie‐line power control of modern interconnected power systems
Authors: Sharma Dushyant , Mishra Sukumar
Published: June 2019

This study presents the application of non‐linear disturbance observer (NDO) for automatic generation control of interconnected thermal area power systems considering generation rate constraints. In this work, any change in electrical power arising in the system due to either load change or change in power output of intermittent renewable energy sources is called a disturbance. This disturbance is estimated using an NDO and the same is rejected by giving an equivalent command to the governor of thermal power units to maintain a power balance in the system; thereby maintaining frequency and tie‐line power flows in each area of an interconnected power system. The analysis is presented on a two‐area power system and it is shown that the proposed control scheme effectively mitigates any active power imbalance in the system not only for normal operations but also when there is large communication delay in the system. The key advantages of the proposed scheme not only include faster frequency and tie‐line power control but also reduced control efforts as compared to other established control schemes. Furthermore, the proposed scheme requires the optimisation of only one control parameter in each area. Therefore, the scheme gives away the requirement of complex optimisation algorithms.
Exact approach for charging of PEVs with V2G capability to improve micro‐grid reliability
Authors: Shams Hamed , Sadeghfam Amin , Rostami Naghi , Tohidi Sajjad
Published: June 2019

Nowadays, the major proportion of fossil fuels is consumed in the transportation systems. Plug‐in electric vehicles (PEVs) can play a significant role in reducing the petrol consumption. A large amount of additional electrical power demand needed for the charging of PEVs may adversely affect the electric grid reliability. Using the charging station in the micro‐grids (MGs) to minimise the total system operation cost in the presence of PEVs with vehicle to grid (V2G) capability is becoming vitally important. In this work, a practical model for charging strategy of PEVs based on typical charge and discharge profiles given by the battery producers is considered. The problem is constrained by the loss of load probability index of reliability. The proposed strategy makes it possible to handle the generation shortage due to the outage of conventional units and intermittency of wind turbine units. Mixed Integer Non‐linear programming is used for the optimal planning of MG in the presence of PEVs. Results show that an appropriate charge and discharge strategy may lead to a significant improvement in the reliability of the considered MG as well as a reduction in the operational cost of the total system.