bluuebunny/crossref_metadata_2025 huggingface dataset:
Xanthones from Gentianopsispaludosa(Hook. f.) Ma ameliorates colonic epithelial-mesenchymal transition through regulating autophagy
Authors: Liu Na , Kou Liang , Liu Yuemin , Bo Shuangqin , jing Ming
Published: September 2022

Ethnopharmacological relevance: Ulcerative colitis (UC) is an immune-mediated, idiopathic, chronic, recurrent inflammatory bowel disease inflammatory bowel diseases (IBD). Gentianopsis paludosa (Hook. f.) Ma, a traditional Tibetan medicine, is commonly used to treat hepatitis, cholecystitis, diarrhea, gastroenteritis, conjunctivitis, scabies, swollen poison and other diseases. The research group replicated the ulcerative colitis (UC) rat model through (2,4-dinitrobenzenesulfonic acid, DNBS）in the early stage, and it was clear that xanthone is the main active components, but the mechanism is still unclear and needs to be further elucidated.
Aim of the study: Inflammatory bowel disease (IBD) is considered as one of the most intractable diseases worldwide. Intestinal fibrosis, as the most serious complication of IBD, can easily lead to intestinal scarring, intestinal stricture and even intestinal obstruction. Therefore, there is an urgent need to accelerate the development of anti-fibrotic drugs for IBD. The purpose of this study was to investigate the protective effect of xanthone from Gentianopsis paludosa (GPX) on the colonic epithelial-mesenchymal transition and its specific mechanism.
Methods: The damage to colonic epithelium was caused by intraperitoneally injecting DNBS, and the therapeutic potential of GPX on colonic fibrosis was detected, which was verified by macroscopic evaluation of rats (disease activity index, DAI;colonic mucosal damage index,CMDI), histopathological staining and Western blotting. In addition, the effect of GPX was tested on NCM460 cells in vitro. The expression levels of EMT-related proteins, mRNAs and autophagy-related proteins, mRNAs in colon epithelial cells were detected by immunofluorescence assay, western blotting, quantitative real-time PCR and other techniques, and the possible mechanisms were explored.
Result: GPX significantly inhibited colonic fibrosis, as preliminarily demonstrated by DNBS-induced body weight gain, DAI, CMDI score reduction and colonic fibrosis area reduction in rats. Moreover, GPX could down-regulate the expression of mesenchymal transition-related genes and proteins, and up-regulate the level of autophagy in colonocytes. Mechanistic studies showed that GPX could affect EMT by regulating autophagy, as evidenced by autophagy inhibitors (3-MA) or agonists (Rapa) that inhibit or enhance this effect of GPX.
Conclusion: Herein, the evidence was provided to support that GPX could effectively inhibit colonic fibrosis, and its mechanism of action may be related to the inhibition of epithelial-mesenchymal transition and the regulation of autophagy in intestinal epithelial cells.
Research on Fall Armyworm (Spodoptera frugiperda, J.E Smith): A bibliometric of scientific research (1980-2022)
Authors: Khanyile Lungelo , Simelane Victor B. , Masuku Landile
Published: September 2022

Fall armyworm (FAW) is a dangerous invasive insect belonging to the Spodoptera genus and it causes a lot of damage to most field crops which can lead to great yield losses. In this study, we analyzed a total of 2754 FAW publications retrieved from the Web of Science database. More than 95% of FAW-related publications were published using the English language. Articles formed 93,5% of the whole FAW-related documents. In the last decade, an increase in the number of publications was observed and the highest number of publications (320) was observed in 2021. FAW-related publications were mostly related to Entomology and Agricultural research areas. The top 5 journals contributing to FAW-related literature were Journal of Economic Entomology, The Florida Entomologist, Environmental Entomology, Pest Management Science, and Journal of Entomological Science, with 270, 218, 106, 75, and 75 publications, respectively. Wiseman BR has the greatest number of publications, 82, followed by Meagher RL and Williams WP with 80 and 68 publications, respectively. The top 5 institutions which contributed the most to FAW literature were the US Department of Agricultural Research Service, Agricultural Research Service, the University of Sao Paulo, the University of Florida, and Louisiana State University with 265, 97, 86, 85, and 83 publications, respectively. In terms of countries, only USA, Brazil, China, and Mexico published more than 200 documents. This study could be used as a guide for future research, and it can be used by researchers to identify other researchers they can collaborate with in FAW-related research.
Effect of Mammary Adenocarcinoma Supernatant on Hepatic Fibroblast Differentiation
Authors: Wang Enze , Zhang Xiangnan , Tao Ning
Published: September 2022

Mammary adenocarcinoma is the most common malignant tumor in women, and the liver is one of the sites with a high incidence of metastasis. This study established a mammary adenocarcinoma-associated fibroblast cell line (ME-iLX-2) that features premetasis niche based on coculture with the supernatant of hepatic stellate cells (LX-2) and mammary adenocarcinoma cells (TS/A). Multiple experiments, including 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT)MTT, Flow Cytometry (FCM), wound-healing, lactic acid, real-time quantitative polymerase chain reaction (qPCR) and WB assays, were carried out to investigate the connection between mammary adenocarcinoma cells and hepatic stellate cells and the source of cancer-associated fibroblasts in the premetastatic microenvironment and to confirm the importance of vascular endothelial growth factor (VEGF) in mammary adenocarcinoma supernatant-induced hepatic fibroblast differentiation.
This study determined the following: 1. After long-term coculture with supernatant, LX-2 significantly promoted the proliferation and migration of tumor cells, and massive apoptosis of LX-2 cells occurred; 2. VEGF expression in LX-2 cells was positively correlated with the duration of coculture with supernatant. In addition, with an established linear regression model, high expression of VEGF is suggested to be one of the molecular properties of cancer-associated fibroblasts.
Tagungsbericht: „Die Konstruktion stärken!“ (28.09. und 29.09.2021, PH Weingarten)
Authors: Hesse Florian
Published: September 2022

Der Beitrag berichtet über die Vorträge, Statements und zentralen Diskussionspunkte der Tagung „Die Konstruktion stärken!“, die Ende September 2021 im digitalen Format an der PH Weingarten stattfand. Mit Konstruktionen waren dabei nicht schüler*innenseitige Lernprozesse, sondern jegliche Bemühungen von Deutschdidaktiker*innen gemeint, die sich auf die Konstruktion von Materialien für die Planung und Durchführung von Unterricht oder auf die Konstruktion von Lerngelegenheiten in der universitären Lehre richten. Diese wurden bei der Tagung aus literaturdidaktischer, sprachdidaktischer und schulpraktischer Perspektive auf Basis unterschiedlicher Bezugstheorien beleuchtet. So gelang es, das in der Vergangenheit eher vernachlässigte Forschungs- und Entwicklungsfeld neu zu konturieren und Anknüpfungspunkte für die weitere Arbeit zu schaffen, die im Fazit des Beitrags zusammengefasst werden.
Tagungsbericht: „Fachdidaktische Entwicklungsforschung in der Deutschdidaktik – Gegenstandsspezifische Lernprozesse in den Blick nehmen“ (22.03.2022 bis 23.03.2022, Bergische Universität Wuppertal)
Authors: Drepper Laura , Uhl Benjamin
Published: September 2022

Der Bericht gibt Einblicke in die Tagung „Fachdidaktische Entwicklungsforschung in der Deutschdidaktik – Gegenstandsspezifische Lernprozesse in den Blick nehmen“. Diese fand am 22. und 23.03.2022 an der Bergischen Universität Wuppertal statt. Im Fokus der Tagung stand die Fragestellung, wie Design-Based Research als Forschungsmethode in der Deutschdidaktik eingesetzt werden kann. Hierzu wurden entsprechende Projekte sowohl unter methodologischer als auch unter fachdidaktischer Perspektive diskutiert.
Migración interna y el acceso a los servicios de salud. El caso de la población afrocolombiana migrante del departamento del Chocó a Medellín
Authors: Asprilla Córdoba Keyra Liseth , Montenegro Martinez Gino
Published: September 2022

La migración interna ofrece oportunidades en términos laborales, educativos y de bienestar. No obstante, también plantea desafíos en varios frentes, entre otras, para el acceso a los servicios de salud. Este artículo describe el acceso a los servicios de salud de una población que migra del departamento del Chocó a Medellín. Para ello, se aplicó encuesta telefónica a 392 personas afrocolombianas migrantes del departamento del Chocó a Medellín. La población que migra del Chocó a Medellín refiere barreras de diversos tipos para acceder a los servicios de salud, con mayor frecuencia, refieren barreras para acceder a los medicamentos, seguido de aquellas barreras para la autorización de procedimientos. De este modo, pertenecer al sistema general de seguridad social en salud no garantiza el acceso efectivo a los servicios. Es necesario la integración de las necesidades de salud de los migrantes internos en las políticas y estrategias nacionales de salud.
El derecho internacional económico en la nueva era digital
Authors: Nikiforovich Sidorov Victor , Victorovna Sidorova Elena
Published: September 2022

La tecnología de la información se introduce en diferentes sectores de la sociedad y cada vez más se introduce en los procedimientos comerciales y relaciones económicas. Las tecnologías de la información en el marco del Derecho Internacional Económico hace muy poco tiempo se habían incorporado en los estudios académicos. La mayoría de los estudios reflejan sobre la regulación de las tecnologías de la información por medio de las normas de la Organización Mundial del Comercio. En el presente artículo se centra en un aspecto que relaciona de la regulación del comercio internacional y comercio electrónico por medio del nuevo concepto de facilitación del comercio que implica la aplicación de las tecnologías de la información como el complemento de las normas del GATT y GATS.
To vax or not to vax? Covid-19 vaccination mandates in light of Vavřička and others v. The Czech Republic
Authors: Kozlová Alena , Bola Kamaal
Published: September 2022

This case report discusses the judgement of the European Court of Human Rights in Vavřička and Others v. the Czech Republic, which remains the only case concerning compulsory vaccination to date. This is particularly important in the context of the COVID-19 pandemic, in which many European States restricted unvaccinated individual’s freedoms in a post-lockdown setting. After outlining the relevant facts and arguments brought by both the applicants and the Government, it comments on the Court’s assessment under Article 8 ECHR by evaluating inter alia the notion of interference and conflicting interests of parents versus children. First and foremost, however, it sheds light on how the case fits into the wider discussion on COVID-19, particularly what standards it puts in place and what implications it bears on future applications concerning COVID-19 vaccination rules. Namely, it illustrates how the threshold of necessity may be established in relation to Article 8 interferences.
Transformación digital: los nuevos escenarios entre el derecho y las TIC
Authors: Buitrago Botero Diego Martín , Pérez Angarita Luis Fernando
Published: September 2022

Desde hace varias décadas el derecho y la tecnología se han venido cruzando, compartiendo escenarios, intercambiando saberes y participando en diferentes actividades de la vida cotidiana; sin embargo, muchos profesionales de estas dos áreas han preferido ignorar, rechazar o desconocer esta realidad, señalando que son profesiones distantes y sin coincidencias.
A pesar de ello con el pasar de los años se evidencia la necesidad no solo de legislar los asuntos informáticos y tecnológicos, sino también una alta incidencia de las Tecnologías de Información y Comunicación –TIC- en los escenarios jurídicos, por tanto, se advirtió que tarde o temprano iba a llegar el momento de enfrentar conjuntamente el tema y diseñar un proceso de transformación digital que involucrara el derecho y las TIC.
Detection of Antibodies against Toxoplasma from Human Serum Sample
using ELISA
Authors: Tak Vibhor , Sharma Kirtika , Srivastava Saumya , Kundu Aditya
Published: September 2022

Background:

Toxoplasmosis is a common worldwide zoonotic infection affecting warm
blooded animals and humans caused by Toxoplasma gondii. Clinical features range from mildfebrile
illness and lymphadenopathy in the immunocompetent host to encephalitisin the immunosuppressed
host (E.g. HIV infected patients). Congenital infection can also occur. For effective control and treatment
of toxoplasmosis, accurate detection of T. gondii infection is important.

Objective:

In this study, ELISA detecting anti-toxoplasma antibodies IgM and IgG has been used for
diagnosing Toxoplasmosis in patients.

Methods:

Enzyme-linked immunosorbentassay (ELISA) was carried out in serum samples collected
from 40 patients to detect anti-toxoplasma IgG and IgM antibodies as a part of work up in suspected
cases. Relevant clinical history was also taken.

Result:

Of the total 40 samples taken, only one sample came positive for IgM and 9 came positive for
IgG antibody. All patients who were seropositivefor T. gondii antibodies had HIV infection. Five patients
were in the age group between 30 to 40 years.

Conclusion:

From the limited data available in this study, it may be recommended to screen for T.
gondii antibodies in HIV patients.
The Association Between Hematologic Indices with TIMI Flow in STEMI
Patients who Undergo Primary Percutaneous Coronary Intervention
Authors: Khaheshi Isa , Parsa Saeed Alipour , Nourian Saeed , Safi Morteza , Namazi Mohammad Hasan , Saadat Habib , Vakili Hossein , Eslami Vahid , Salehi Ayoub , Kiaee Farshid Heidarpour , Sohrabifar Nasim
Published: September 2022

Background:

The Primary Percutaneous Coronary Intervention (PPCI) is the preferred
therapeutic strategy for patients who experienced ST-Elevation Myocardial Infarction (STEMI).

Objective:

We aimed to evaluate the association of hematological indices, including hemoglobin
level, platelets, White Blood Cells (WBCs) count, and MPV before PPCI with the TIMI grade flow
after PPCI.

Methods:

STEMI patients who experienced PPCI were included in the present retrospective crosssectional
study. Then participants were divided into three groups based on their post-procedural
TIMI flow grades. Demographic data and hematologic indices of patients before PPCI were collected
and their association with the TIMI grade flow after PPCI was evaluated. To compare the quantitative
and qualitative variables, chi-square and t-tests were performed, respectively.

Results:

We found that elevated levels of hemoglobin and decreased levels of MPV had a significant
association with an advanced grade of TIMI flow. Interestingly, in the normal range, there was
a significant association between higher platelet count and TIMI-flow grade 1. Besides, TIMI flow
grades 2 and 3 had a significant association with low and moderate platelets count, respectively.

Conclusion:

In conclusion, evaluating MPV, platelets, and hemoglobin levels before PPCI as easy
and accessible parameters may be able to identify high-risk STEMI patients undergoing PPCI.
Medium-chain Fatty Acids for the Prevention or Treatment of Alzheimer’s Disease: A Systematic Review and Meta-analysis
Authors:   Murdoch University, Castro Carolina , Dias Cintia ,   The University of Newcastle, Sohrabi Hamid ,   Murdoch University, Shah Tejal ,   Murdoch University, Chatterjee Pratishtha ,   Macquarie University, Hillebrandit Heidi ,   Macquarie University, Fuller Stephanie ,   Macquarie University, Garg Manohar ,   The University of Newcastle, Martins Ralph ,   Macquarie University
Published: September 2022

In preclinical AD, the brain gradually becomes insulin resistant causing a cellular energy deficit, which leads to the accumulation of free radicals increasing inflammation and damaging neurons, thus ketone bodies offer an alternative energy source having the potential to supply the insulin-resistant brain with energy and may improve cognition.
Flame Retardant Polyurethane Foams Using Vegetable Oil-based polyol
Authors:   Pittsburg State University, Kote Prashant , Asare Magdalen ,   Pittsburg State University, Chaudhary Sahilkumar ,   Pittsburg State University, Dawsey Tim ,   Pittsburg State University, Gupta Ram ,   Pittsburg State University
Published: September 2022

Polyurethanes can be used in many applications by modifying their properties via facile methods. Most of the polyurethanes currently used for industrial applications originated from petrochemical-based chemicals. There is a growing demand in industries to use renewable resources for polyurethanes. Vegetable oil-based polyurethanes have shown properties comparable to that of petroleum-based polyurethanes. In this research, sunflower oil was used as a renewable resource for polyurethanes. Rigid polyurethane foams were prepared using sunflower-based polyols. The polyols were synthesized via epoxidation followed by a ring-opening reaction. Epoxy number, hydroxyl number, viscosity, and spectroscopy characterizations confirm the synthesis of bio-polyol. One of the major issues in polyurethanes is their high flammability which was reduced by using flame-retardants. Two flame-retardants using melamine and diphenylphosphinic acid (DPPMA) and a phosphorous‐nitrogen intumescent flame‐retardant (2,2‐diethyl‐1,3‐propanediol phosphoryl melamine, DPPM) were synthesized and used in bio-based polyurethanes. as used as an additive flame retardant. The foams with DPPMA and DPPM showed high closed cell content ( >90%) with a high compression strength of 217 kPa and 208 kPa, respectively. The microstructure analysis of the foams using scanning electron microscopy revealed an even distribution of the pore size. The addition of DPPMA and DPPM in polyurethane foams results in the formation of a protective char layer during the flammability test and reduces the weight loss from 43% to 2.5% and 1.4% and burning time from 70 seconds to 6 seconds and 4.5 seconds, respectively. Our research suggests that sunflower oil could be a potential candidate for the polyurethane industries and DPPMA and DPPM can be used as an effective flame-retardant in these bio-based polyurethane foams.
Antioxidative Functionality of Natural Olive Extract vs. Synthetic Tertiary Butyl Hydroquinone in Sunflower Oil During Deep Frying
Authors:   International Foods Stuff Company ( IFFCO), Nichlavose Mayamol , Melnikov Sergey ,   International Foods Stuff Company ( IFFCO), Sarfare Rupesh ,   International Food stuff company (IFFCO), Jain Chirag ,   International Food stuff company (IFFCO)
Published: September 2022

Refined, bleached and deodorized (RBD) sunflower oil (SFO) supplemented with (i) 100ppm and (ii) 200ppm olive extract (OE), (iii) 200ppm tertiary butyl hydroquinone (TBHQ), (iv) combination of 100ppm OE and 100ppm natural tocopherol (TOCOL), as well as (v) antioxidant (AOX) free SFO were used for deep frying experiments. Experimental design implied 6 consecutive potato chips’ deep frying cycles for 5 consecutive days. SFO samples were analyzed for the content of total polar compounds (TPC) and free fatty acids (FFA), as well as p-anisidine values (AV) and red/yellow (R/Y) color values. Results showed that the addition of AOX to SFO reduce both hydrolytic and oxidative changes in the frying media. TPC content in SFO with 100 ppm OE was similar to that in SFO with 200ppm TBHQ, and it was 2.8 times lower than TPC content in SFO without AOX after 5 days of deep frying. Enhancement of OE level to 200ppm, as well as the use of OE/TOCOL combination did not show any improvement in the suppression of TPC formation. The AV values of SFO with 100 ppm OE and SFO with 200ppm TBHQ were nearly identical and comparable with those in the presence of 200ppm OE and 100ppm OE plus 100ppm TOCOL. AV of SFO without added AOX was 77% higher than that of SFO with 100ppm OE. SFO with 100ppm and 200ppm OE exhibited reduced formation of FFA compared to SFO without AOX, SFO with TBHQ and SFO with combination of OE and TOCOL. No significant differences in R/Y color values of SFO with 100-200ppm OE, as well as with 200ppm TBHQ, were observed; however, color values of SFO without AOX were ca 2 times higher vs. SFO with added AOX.
ESR Photochemical Method for Evaluating Oil Oxidation by Spin Trapping Method
Authors:   The Institute of Food Research, NARO, Kameya Hiromi
Published: September 2022

To determine the degree of oxidation in vegetable oil, a photochemical method using the electron spin resonance (ESR) spin trapping technique was developed. Heat-treated vegetable oil was subjected to short UV illumination, producing alkyl-oxyl radicals, and these were identified and quantified using the proposed ESR spin trapping technique. ESR signal intensity was used as an indicator of oil oxidation, and it increased with increasing heat-treatment time. The results were compared with those obtained using conventional peroxide-value (PV) and acid-value (AV) methods. The proposed method was in agreement with the PV method to some extent, at least in the early stage of heating. Overall, the proposed method is demonstrated to be highly sensitive and capable of detecting early-stage oxidation in vegetable oil.
Study of the Oxidative Stability of Oleogels Structured with Beeswax Fractions
Authors:   Federal Research Center of Nutrition, Biotechnology and Food Safety,, Sobolev Roman , Frolova Yuliya ,   Federal Research Center of Nutrition, Biotechnology and Food Safety,, Sarkisyan Varuzhan ,   Federal Research Center of Nutrition, Biotechnology and Food Safety,, Kochetkova Alla ,   Federal Research Center of Nutrition, Biotechnology and Food Safety,
Published: September 2022

Combining the beeswax fractions is an effective way of structuring edible oils. However, their effect on oleogel oxidative stability is still not studied. Thus, the study on the influence of beeswax and combinations of its fractions on the edible oleogels oxidation was the objective of this research.Four fractions of beeswax (A, B, C, D) were isolated using preparative flash-chromatography and characterized by TLC and HPLC-ELSD. Sunflower oil was used to prepare oleogels (at 90 °C for 30 minutes) with a 6% of gelator. The fatty acid composition was evaluated by GC. The samples were stored at 35°C for 20 days, monitoring the oxidation using: PV, AV, CDV, TOTOX, HS-SPME-GC-MS. The induction period was determined using the OXITEST reactor.We have shown that fraction A contained hydrocarbons ( >99%); B - monoesters ( >95%); C - wax esters ( >66%), alcohols ( >29%), and free fatty acids ( >4%); D - alcohols ( >49%), free fatty acids ( >40%) and wax esters ( >10%). Combinations of A+B, A+B+C, and A+B+D gelators were made using fractions in equal amounts. The fatty acid composition of freshly prepared oleogels and oil didn't differ (p >0.05). Sunflower oil had the best oxidative stability among all samples. The A+B-based oleogel had the highest oxidative stability among the oleogels. Hexanal is shown to be the main volatile organic compound formed during the oxidation of sunflower oil. The volatile compounds profile of the oleogels also included ketones, alcohols, and terpenes. Beeswax-based oleogel had the lowest induction period, which indicates the presence of prooxidant components. A close correlation was found between the oxidation rate of oleogels and the content of free fatty acids (r2=0.8195) in the gelator.This study shows that the use of beeswax fractions, compared to beeswax itself, results in fat-containing products with higher oxidation stability.
The Information Sharing Behaviors of Dietitians and Twitter Users in the Nutrition and COVID-19 Infodemic: Content Analysis Study of Tweets
Authors: Charbonneau Esther , Mellouli Sehl , Chouikh Arbi , Couture Laurie-Jane , Desroches Sophie
Published: September 2022

Background

The COVID-19 pandemic has generated an infodemic, an overabundance of online and offline information. In this context, accurate information as well as misinformation and disinformation about the links between nutrition and COVID-19 have circulated on Twitter since the onset of the pandemic.

Objective

The purpose of this study was to compare tweets on nutrition in times of COVID-19 published by 2 groups, namely, a preidentified group of dietitians and a group of general users of Twitter, in terms of themes, content accuracy, use of behavior change factors, and user engagement, in order to contrast their information sharing behaviors during the pandemic.

Methods

Public English-language tweets published between December 31, 2019, and December 31, 2020, by 625 dietitians from Canada and the United States, and Twitter users were collected using hashtags and keywords related to nutrition and COVID-19. After filtration, tweets were coded against an original codebook of themes and the Theoretical Domains Framework (TDF) for identifying behavior change factors, and were compared to reliable nutritional recommendations pertaining to COVID-19. The numbers of likes, replies, and retweets per tweet were also collected to determine user engagement.

Results

In total, 2886 tweets (dietitians, n=1417; public, n=1469) were included in the analyses. Differences in frequency between groups were found in 11 out of 15 themes. Grocery (271/1417, 19.1%), and diets and dietary patterns (n=507, 34.5%) were the most frequently addressed themes by dietitians and the public, respectively. For 9 out of 14 TDF domains, there were differences in the frequency of usage between groups. “Skills” was the most used domain by both groups, although they used it in different proportions (dietitians: 612/1417, 43.2% vs public: 529/1469, 36.0%; P<.001). A higher proportion of dietitians’ tweets were accurate compared with the public’s tweets (532/575, 92.5% vs 250/382, 65.5%; P<.001). The results for user engagement were mixed. While engagement by likes varied between groups according to the theme, engagement by replies and retweets was similar across themes but varied according to the group.

Conclusions

Differences in tweets between groups, notably ones related to content accuracy, themes, and engagement in the form of likes, shed light on potentially useful and relevant elements to include in timely social media interventions aiming at fighting the COVID-19–related infodemic or future infodemics.
Optokinetic Stimulation Glasses for the Treatment of Hemispatial Neglect (Preprint)
Authors: Lim Chun
Published: September 2022

UNSTRUCTURED

Objective To determine whether a pair of computerized see-through glasses displaying optokinetic stimulation (OKS) can reduce the symptoms of hemispatial neglect.
Methods Eighteen patients with right hemispheric strokes were enrolled in a randomized, blind, placebo-controlled trial. Patients with hemispatial neglect were tested before and during visual stimulation while wearing the neglect rehabilitation glasses. Primary outcome was percent change in the behavioral inattention score.
Results Patients who received OKS averaged a significant 32.9% +/- 6.49%) improvement of their neglect score compared to control subjects who had a 7.29% +/- 10.5% worsening.
Discussion Our neglect rehabilitation glasses ameliorates the symptoms of hemispatial neglect in stroke patients.
Use of Social Media for Patient Education in Dermatology: Narrative Review (Preprint)
Authors: Wojtara Magda Sara
Published: September 2022

BACKGROUND

Social media has rapidly become one of the main avenues for news and communication among those with access to technology. Nearly 60% or 4.7 billion people worldwide use social media. Different social media networks provide users with a barrage of posts, opinions, and transformations. With this noticeable uptick in physician and patient education usage of social media, exploration of the impacts of social media on patient education in dermatology is crucial.

OBJECTIVE

The goal of this narrative review was to evaluate existing peer-reviewed literature examining the use of social media for patient education in dermatology and to establish trends and implications. Additional attention was given to different social media sites, and potential differences in modalities of posts such as short-form videos on TikTok and Instagram Reels, long-form videos on YouTube, and infographics on Twitter, Instagram, and Facebook.

METHODS

PubMed, Access DermatologyDxRx, and Scopus searches of peer-reviewed publications were performed to discover articles with social media and patient education keywords in combination with other health care–relevant or dermatology-relevant keywords. Subsequently, the screening of these studies was performed by the author who has experience with education and research experience in health care, dermatology, social media, and telehealth. Ultimately, the selected articles were summarized through qualitative analysis of key points and presented for further discussion.

RESULTS

Through this narrative review, the researcher was able to identify several publications focusing on dermatology and social media. Some common subject areas included the use of social media for the promotion of private dermatology practices, residency programs, and research journals. So long as providers, such as dermatologists, take ethical considerations into account, these platforms can provide patients with curated educational content. In addition, several publications emphasized the use of social media as a form of patient education on dermatologic conditions but also as a source of misinformation.

CONCLUSIONS

This narrative review illuminated the use of social media as a form of patient education for dermatology, with its applications addressed across many demographics and situations. As social media platforms continue to update their algorithms, content filters, and posts, social media may become a reputable form of patient education in dermatology. Future studies and innovations should continue to explore innovations in this space, the efficacy of different modalities of posts, and longitudinal differences in patient outcomes and health literacy.
The Impacts of Computer-Aided Detection of Colorectal Polyps on Subsequent Colonoscopy Surveillance Intervals: Simulation Study (Preprint)
Authors: Lui Ka Luen Thomas , Liu Sze Hang Kevin , Leung Kathy , Wu Joseph T , Zauber Ann G , Leung Wai Keung
Published: September 2022

BACKGROUND

Computer-aided detection (CADe) of colorectal polyps has been shown to increase adenoma detection rates, which would potentially shorten subsequent surveillance intervals.

OBJECTIVE

The purpose of this study is to simulate the potential changes in subsequent colonoscopy surveillance intervals after the application of CADe in a large cohort of patients.

METHODS

We simulated the projected increase in polyp and adenoma detection by universal CADe application in our patients who had undergone colonoscopy with complete endoscopic and histological findings between 2016 and 2020. The simulation was based on bootstrapping the published performance of CADe. The corresponding changes in surveillance intervals for each patient, as recommended by the US Multi-Society Task Force on Colorectal Cancer (USMSTF) or the European Society of Gastrointestinal Endoscopy (ESGE), were determined after the CADe was determined.

RESULTS

A total of 3735 patients who had undergone colonoscopy were included. Based on the simulated CADe effect, the application of CADe would result in 19.1% (n=714) and 1.9% (n=71) of patients having shorter surveillance intervals, according to the USMSTF and ESGE guidelines, respectively. In particular, all (or 2.7% (n=101) of the total) patients who were originally scheduled to have 3-5 years of surveillance would have their surveillance intervals shortened to 3 years, following the USMSTF guidelines. The changes in this group of patients were largely attributed to an increase in the number of adenomas (n=75, 74%) rather than serrated lesions being detected.

CONCLUSIONS

Widespread adoption of CADe would inevitably increase the demand for surveillance colonoscopies with the shortening of original surveillance intervals, particularly following the current USMSTF guideline.
The Potential of Rhizophagus intraradices and Trichoderma asperellum to Induce Shallot Resistance against Twisted Disease
Authors: Artanti Hertina , Joko Tri , Somowiyarjo Susamto , Suryanti Suryanti
Published: September 2022

Twisted disease caused by Fusarium spp. is one of the primary diseases on shallots with potency to cause enormous losses by causing stunting and bulb rot. One alternative disease control is the induction of plant resistance since the seed stage. The aim of this study was to determine the content of salicylic acid, jasmonic acid, and phenolic compounds of shallot bulb seeds coated with biological control agents as a resistance response to twisted disease. The shallot cultivar used was Crok kuning. The treatments used in this study were the type of biological control agents, including Rhizophagus intraradices and Trichoderma asperellum, combined with and seed coating application time (one month before planting and simultaneously at planting). Biological control agents in the form of powder formulation applied as seed coating material and seeds were stored for one month before planting. The results showed that application of biological agents delayed the occurrence of the twisted disease symptoms. The salicylic acid content from plant treated with R. intraradices at the time of planting was slightly higher than the control. The jasmonic acid content in T. asperellum plants treated at planting was higher than then control. Total phenolic content from plants treated with T. asperellum at planting time was higher than the control. In general, application of biological control agent as seed coat did not result in significant increase in salicylic acid, jasmonic acid nor the phenolic compounds, compared to the pathogen infected control.
DRUGI SVETSKI RAT I DOPRINOS SRPSKOG NARODA POBEDI NAD NACIZMOM
Authors: Kajtez Ilija , Starcevic Srdjan
Published: September 2022

Rad predstavlja spoj filozofskih i socioloških razmatranja problema rata uopšte i Drugog svetskog rata posebno, kao i doprinosa srpskog naroda pobedi nad nacizmom i fašizmom u ovom ratu koji se sagledava iz istorijskog i politikološko-sociološkog ugla. Autori prvo daju kratak pregled različitih pogleda na rat i dominantnih problema sa kojima se suočava svako ko pokuša da definiše pojam rata, s namerom da istaknu specifičnost Drugog svetskog rata kao najveće arene totalnog društvenog oružanog sukoba i do sada najočiglednijeg približavanja apsolutnom ratu. Poseban akcenat autori stavljaju na spoj onoga što se može odrediti kao zaostavština ratova Francuske revolucije i Napoleonovih ratova sa tehničkim napretkom i političkim zlom oličenim u ideologiji fašizma i nacizma. Potom se autori okreću načinu na koji se srpski narod suprotstavio zlu nacizma i fašizma, pokazujući da su na prostoru nekadašnje Kraljevine Jugoslavije postojala dva antifašistička pokreta otpora i da su u oba dominirali pripadnici srpskog naroda.
NEMANJA KAO PRVOSVEŠTENIK
Authors: Vujovic Ognjen
Published: September 2022

Čini se da je Sveti Sava načinio koncepciju o Nemanji kao prvosvešteniku srpskoga naroda. To je trebalo da podupre njegovu apsolutnu svetovnu vlast među svojim narodom u svojoj državi. Takođe, trebalo je da trasira istu takvu ulogu njegovih naslednika na prestolu. Savini spisi jesu hrišćankog, crkvenog karaktera i kao takvi imaju specifične termine, pojmove i značenje. Međutim, Nemanjina vlast je ipak svetovna kategorija čijem opravdanju i jačanju su ti spisi, pored ostalog, služili. Zato u njima treba tražiti i svetovnu, političku svrhu. Vlast je kategorija koja od kada je sveta i veka pokazuje univerzalne karakteristike. Rimski carevi su se zbog pobede hrišćanstva morali odreći božanske uloge, ali su se baš zato grčevito držali prvosvešteničke uloge. Tu težnju pokazuje i Savin Nemanja. Neposredna Božja volja je nužna da stvori Zavet između Boga i izabranog naroda, ali je zato Božja promisao dovoljna da stvori prvosveštenika.
Developing an Individual Excel Sheet for Design and Analysis of Beam and Slab
Authors: Tattimani Sachin , Cholappanavar Sri. P. I.
Published: September 2022

Abstract: Analysis and design of RC structures using FEM based software package needs basic knowledge of that software. This project focuses on developing a excel sheet with simple user interface to analyze and design RC structures without any prior knowledge of software. This excel sheet considers only the gravity loads. Grids in X and Y directions are defined in the sheet. User can enter distance between grids. This sheet provides design of footing and column.
The Effect of Different Surface Treatments to Reduce Surface Roughness Before PVD Coatings
Authors: Rathnam G. Santhosha
Published: September 2022

Abstract: Titanium and its compounds are used in aerospace, automotive, and chemical but currently it's considerably used in biomedical usages due to its excellent combination of low viscosity, high strength to weight rate, high erosion resistance, and biocompatibility, still, the main limit is poor tribological parcels therefore it can not be successfullyused.Wide range of face treatments disposition of shells similar as scraping and melting of face and cumulative processes similar as plating. For essence, face variations are plating or sheeting processes. There are different types of face coatings charging, electrochemical coatings, vapor deposit, conversion coatings, and thermal spraying among them PVD is vapor deposit which the coatings are hard and thin film. In PVD coatings Nitrides and carbide coatings are classified. In which nitride coatings TiN, TiAlN, and duplex TiAlN and drum were deposited on a substrate( Ti6Al4V). But for deposit, the face roughness should be0.08 µm. Thin hard coatings have good wear and tear resistance only when they've good adhesion and certain face roughness. To reduce face roughness different face treatments are acclimated similar as shot firing, sandblasting, drawing, ray figure, grinding and polishing, etc. Sandblasting was done but the face roughness didn't drop to0.08 µm. so required face roughness was attained by grinding and polishing with sandpaper, and it was diamond polished
Data Analytics as a Key to Fantasy Premier League
Authors: Gowda Arya L
Published: September 2022

Abstract: This paper aims to provide the reader with a review of the Fantasy Premier League (FPL) driven by data science, A competition in which participants select a fictional team from among the players in the real-world league and earn points according to the actual performance of the players. Fantasy Premier League (FPL) performance predictions tend to be algorithmically based solely on historical statistical data. The main factor driving fantasy sports are three main factors which are Competition, Bragging rights and money. In this paper we present a study for recommending FPL player selections for upcoming game weeks.
The Effect of Parents' Interest in School Life and Academic Interest on Children's Self-esteem: Focusing on the Mediated Effect of Children's School Adaptation and Happiness
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Jo Hyeyoung , Kwon Jeongyoon
Published: September 2022

Objectives The purpose of this study is to investigate the mediated effect of children's school adaptation and happiness in the influence of parents' interest in school life and academic interest on children's self-esteem.
Methods For this, National Youth Policy Institute(2018) finally analyzed a total of 707 people who responded to both research variables in the parental survey area and the child and youth survey area in the Korean Children and Youth Panel Survey(KCYPS). The correlation between the research variables was analyzed by Pearson Correlation Coefficient(PCC), the structural relationship was analyzed by structural equation, and the direct and indirect effects and total effects were verified by two-sided test using bootstrap in the 95% confidence interval.
Results The main results are as follows. First, focusing on self-esteem, there was no statistically significant correlation with school life interest, which is a parent variable, but there was a statistically significant positive correlation with academic interests. There was no statistically significant correlation between school life adaptation and teacher adaptation in children's variables, but there was a statistically positive correlation between academic performance adaptation, peer adaptation, and happiness. Second, parents’ interest on school life mediated completely through the path of ‘children's school adaptation⟶children's happiness⟶children's self-esteem’, and in this process, children's happiness was found to be double mediated. It showed that parents' academic interest completely mediated and influenced the path of ‘children's happiness⟶children's self-esteem’.
Conclusions The results of this study confirm once again that children's happiness is a factor influencing self-esteem. Thus, I would like to discuss various ways to improve children's happiness.
Território, significados e as potencialidades da educação em saúde para o uso racional de medicamentos
Authors: Campos Hudson Manoel Nogueira , Mattos Mussio Pirajá
Published: September 2022

A Educação em Saúde surge como um modelo de abordagem potencializadora para a promoção do uso racional de medicamentos. Desse modo, a aplicação de métodos educativos irá beneficiar os usuários por meio da democratização dos conhecimentos necessários para práticas seguras em saúde. O presente estudo teve o objetivo de relatar as potencialidades de uma atividade de educação em saúde para o uso racional de medicamentos. Trata-se de um relato de experiência do projeto de extensão “Farmácia em ação: educação em saúde para promoção do uso consciente de medicamentos”. Para desenvolvimento da atividade educativa foram gerados espaços democráticos de diálogos com construção de materiais didáticos e formas diversas de comunicação. A ação ocorreu em uma feira livre no município de Barreiras, Bahia. Foram utilizados processos educacionais sob o referencial teórico de Paulo Freire, em simbiose com Manoel de Barros e Rubem Alves. A ação mostrou o aperfeiçoamento da formação dos educandos ao promover a protagonização necessária para atender as demandas individuais e singulares. Além disso, revelou um espaço aberto para a prática do conhecimento com desafios reais. A ação educativa estimulou o desenvolvimento de competências que são fundamentais para a atuação profissional, fortaleceu a promoção de uma prática medicalizadora mais consciente e potencializou as tecnologias leves como uma premissa ampliada do cuidado.
Diálogos sobre políticas públicas de saúde: um olhar da revisão integrativa
Authors: Rodrigues Vânia Maria Pessoa , Soares Themis Cristina Mesquita , Bezerra Sara Taciana Firmino
Published: September 2022

As políticas públicas com ênfase na saúde vêm adquirindo espaço nas discussões das últimas décadas, principalmente após a instituição do Sistema Único de Saúde (SUS), considerado uma das maiores conquistas sociais do país. Este trabalho busca verificar as evidências científicas no diálogo entre as políticas de saúde do SUS com a política de atenção integral à saúde da mulher e educação em saúde. Para isso, realizou-se uma revisão integrativa de literatura em duas bases de dados, SciELO e Scopus/Elsevier. A amostra final foi composta por seis artigos, que foram submetidos à análise. Identificaram-se os objetivos, as diretrizes, a organização e o funcionamento de algumas políticas de saúde a partir do SUS, no campo específico da política de atenção integral à saúde da mulher e das discussões em relação à educação em saúde. Os artigos apontaram para a democratização das ações e dos serviços de saúde a partir do SUS, que permitiram externar um olhar para a garantia dos serviços de saúde na atenção à saúde da mulher, independentemente de classes sociais e condições de vida. As ações de educação em saúde, por sua vez, passaram por ajustes discretos na maior parte do tempo, pontuados por momentos de transformações e implementações de serviços de promoção e prevenção à saúde. Espera-se que o desenvolvimento das ações de educação em saúde seja interface constante da Política Nacional de Saúde e da Política Nacional de Educação Permanente em Saúde, caso contrário, tais práticas poderão se tornar esporádicas em determinadas épocas ou em governos específicos, acarretando uma lacuna entre teoria e prática.
ANÁLISE SITUACIONAL DA GESTÃO DO CUIDADO NO SERVIÇO DE SAÚDE MENTAL DO ESTADO DO AMAZONAS
Authors: Figueiredo Andre Junior de Lima , Reis Ernane Júnior da Silva , Junior Gilmar Antoniassi
Published: September 2022

This is a qualitative study of a descriptive and exploratory nature of the integrative review type; whose objective is to map the mental health service related to the Psychosocial Care Center in the State of Amazonas, through data published in government research sources and/or non-governmental organizations, in order to discuss the management of care for the user of the Mental health service. Brazil has 2,742 CAPS "Psychosocial Care Center" enabled, distributed in 1,845 municipalities in all states and in the Federal District, specifically in the States of Amazonas, a total of 24 CAPS. The present scientific research presented a situational analysis of the management of care in the mental health service of the state of Amazonas, in this way the CAPS is a public service, of daily care, which was created not only for the treatment of users, but their actions. they are also aimed at assisting users in their family, social and community reintegration. However, it was possible to perceive the need to expand this device to all Brazilian states and work for policies and improvement both in physical structures and in expanding the range of professionals working in CAPS, the importance of following the guidelines and legislation that indicate an ideal number of professionals to meet the great demands of the Center. Psychosocial Care, which indicates the importance of efficient management.
Together in diversity: insights and wisdom from LGBTQ+ people working in STEM
Authors: Bandelli Andrea
Published: September 2022

“The Queer Variable” is an edited collection of 40 interviews with LGBTQ+ people working in STEM. The interviews reveal the breadth of issues related to exclusion, discrimination, prejudice that LGBTQ+ people face; but also a remarkable progress and advancement of the whole STEM field to be more diverse, inclusive and equitable. The book is an empowering and enlightening reading for all those who are professionally active in STEM.
Rethinking Methodologies: Implications for Research on International Students
Authors: Neupane Dhruba
Published: September 2022

Research in international student success, satisfaction, and challenges seems still to be constructed around the colonial, imperial paradigm. Informed by deficit models of language, culture, and literacy teaching, such research portrays international students’ challenges in terms of deficiency; discounts other languages, cultures, and literacy education; and reinstitutes the progressive and paternalistic role of the West, reifying its linguistic and cultural superiority. This essay interrupts the still dominant narrative that recreates the old binaries in two ways: (a) It frontloads the need to adopt strength-based approaches to counter dominant methodological paradigms from which much of knowledge about culturally and linguistically different/disadvantaged (CLDI) students is derived, and (b) based on my own ethnographic study on a South Asian immigrant population in Canada, it demonstrates that what the old paradigm views as deficits can and should be the very measures from which to appraise student success and satisfaction. Accordingly, the article’s main objectives are twofold: (a) expose the weaknesses of the deficit models of language, culture, and competence and (b) stress the need to reshape international student studies in higher education as a field of inquiry by foregrounding appreciative models and methodologies.