bluuebunny/crossref_metadata_2025 huggingface dataset:
АНАЛИЗ ОТРАСЛЕВОЙ СТРУКТУРЫ ЭКОНОМИКИ КАЗАХСТАНА
Authors: DYATLOV V. , SALZHANOVA Z.
Published: October 2023

This article describes the analysis of economic indicators of the industrial sector. In particular, the mining and manufacturing industries, the dependence of the economic sphere on the oil industry, and their impact on the GDP of the Republic of Kazakhstan in general are affected. Suggestions are also given on a possible way to solve the existing economic problems.

в данной статье описан анализ экономических показателей промышленного сектора. В частности, затрагиваются горнодобывающая и обрабатывающая промышленность, зависимость экономической сферы от нефтяной промышленности и их влияние на ВВП Республики Казахстан в целом. Также даются предложения о возможном способе решения существующих экономических проблем.

Бұл мақалада өнеркәсіп секторының экономикалық көрсеткіштерін талдау сипатталған. Атап айтқанда, тау-кен өндіру және өңдеу өнеркәсібі, экономикалық саланың мұнай өнеркәсібіне тәуелділігі және олардың жалпы Қазақстан Республикасының ЖІӨ-не әсері қозғалады. Сондай-ақ бар экономикалық проблемаларды шешудің ықтимал тәсілі туралы ұсыныстар беріледі.
РАЗВИТИЕ РОДНОГО ЯЗЫКА В НАШЕЙ СТРАНЕ
Authors: СИДИКОВА Г.
Published: October 2023

Мақалада еліміздің өзіндік санасын қалыптастыру мен дамытуда маңызды рөл ойнайтын мемлекеттік тіліміз қазақ тілі жайында сөз қозғалады.

В статье рассматривается наш государственный язык — казахский язык, который играет важную роль в формировании и развитии самосознания страны.

The article deals with our state language - the Kazakh language,which plays an important role in the formation and development of national identity .
КӨРНЕГІ КЕҢЕС ЖӘНЕ РЕСЕЙ ӘКІМШІЛІГІ ҒАЛЫМ ПРОФЕССОР ДЕМЬЯН НИКОЛАЕВИЧ БАХРАХТЫҢ ЕСКЕ АЛУЫ
Authors: ТАТАРЯН В.
Published: October 2023

Статья посвящена памяти одного из выдающихся представителей науки советского и российского административного права доктора юридических наук, профессора, Заслуженного деятеля науки Российской Федерации Демьяна Николаевича Бахраха. Данный ученый внес значительный вклад в развитие и совершенствования административно-правовой науки, подготовил плеяду выдающихся учеников, был прекрасным педагогом и высококвалифицированным юристом.

Мақала кеңестік және ресейлік әкімшілік құқық ғылымының көрнекті өкілдерінің бірі, заң ғылымдарының докторы, профессор, Ресей Федерациясының еңбек сіңірген ғылым қайраткері Демьян Николаевич Бахрахты еске алуға арналған. Бұл ғалым әкімшілік-құқықтық ғылымның дамуы мен жетілдірілуіне елеулі үлес қосты, озат студенттердің галактикасын дайындады, тамаша ұстаз және жоғары білікті заңгер болды.

The article is dedicated to the memory of one of the outstanding representatives of the science of Soviet and Russian administrative law, Doctor of Law, Professor, Honored Scientist of the Russian Federation Demyan Nikolaevich Bakhrakh. This scientist made a significant contribution to the development and improvement of administrative and legal science, prepared a galaxy of outstanding students, was an excellent teacher and a highly qualified lawyer.
ПРОБЛЕМЫ ОРГАНИЗАЦИИ РАБОТЫ С МОЛОДЕЖЬЮ NEET-КАТЕГОРИИ
Authors: ЗҰЛХАРНАЙ Ғ.
Published: October 2023

NEET жастар — XX ғасырдың соңына қарай пайда болған мәселе. Бұл ұғым кейінгі жылдары көбірек айтылғанмен, ондай жастардың бұрыннан бар екені жасырын емес. Жастардың бұл тобын сараптаумен Бүкіләлемдік банк айналыса бастауы, мұның әлемдік деңгейдегі күрделенген мәселе екенін көрсетіп отыр. Мақалада еліміз:де, облыста мәселе қалай шешілуде, қай бағытта шараларды жүргізу қажет екені қарастырылады.

NEET-молодежь — это проблема, возникшая в конце двадцатого века. Тот факт, что Всемирный банк анализирует эту группу молодых людей, показывает, что это сложный вопрос на глобальном уровне. В статье говорится о решении проблемы в стране, в регионе, в каком направлении надо принимать меры.

NEET youth is a problem that emerged at the end of the twentieth century. The fact that the World Bank is analyzing this group of young people shows that this is a complex issue at the global level. The article talks about solving the problem in the country, in the region, in which direction measures should be taken.
Optimization Of Passport Issuance Rules For Prospective Indonesian Migrant Workers In The Formal Sector (Case Study In Class I Immigration Office Non-Tpi Tangerang)
Authors: Fahrenzky Dino , Herlina Anita
Published: October 2023

The high number of unemployed in the Tangerang area and the increased demand forincreasedonesian Migrant workers from the count having a cooperation contract with the Indonesian side that people are willing to become PMI with the auto. Types of Indonesian Migrant Workers in the formal sector are classified into the types of Indonesian Migrant Workers who work for employers who are legal entities. The rules governing passport issuance requirements for prospective Indonesian migrant workers are regulated in the Minister of Law and Human Rights Regulation Number 8 of 2014 concerning Ordinary Passports and Travel Letters. Like PassportsA recommendation letter for issuing passports from the Manpower Office is one requirequirementgiving ta ticket fovisato stive, Indonesian migrant workers. Still, in its implementation at the Immigration Office Class I NoNon-Non-TPIgerangrospective, Indonesian migrant workers, especially in the formal sector, often do not take care of issuing recommendation letters for issuing passports from the Manpower Office for various reasons. Therefore, it is explained that the implementation of regulations for PMI candidates who register for passport issuance at the Class I Non-TPI Tangerang Immigration Office is explained whether the rules for PMI candidates in the formal sector are optimal. Therefore, it is necessary to optimize the laws governing the requirements for issuing passports for prospective Indonesian migrant workers, especially in the illegal industry, whiwhiwhicis optimal. This can be seen from the immigration system at the time of data entry; only prospective migrant workers in the informal sector are required to input PMI ID, while profuturedonesian migrant workers in the formal sector do not enter PMI I, D so the data entry process can continue. Thereforeurgente copy of the recommendation letter for passport issuance from the Manpower Office is only focused on prospective Indonesian migrant workers in the informal sector, not on prospfuturenesian migrant workers in the formal sector.
Factors Analysis Of Decision Consideration Of The Class I Immigration Office Banda Aceh On The Immigration Administrative Action In The Case Of Yousuf Karim
Authors: Mudawar M. Al
Published: October 2023

Law enforcement is a matter of applying the law from the basis of legal actions and legal relations in the life of society and the state. Law enforcement can be used both as a major and a narrow one, so that in general all legal subjects are involved in all legal actions. Any individual or legal entity that adopts a common legal basis. Basically, law enforcement against Yousuf Karim is regulated based on immigration criminal provisions in article 113 and article 126 letter c, but the reality on the ground is that Yousuf Karim is subject to Immigration Administrative Action sanctions in the form of an obligation to reside in the territory of Indonesia and detention in the Detention Room. Immigration Kanim Banda Aceh. Basically the role of law enforcement in the Yousuf Karim case is very important because there are office holders who have the authority and policies taken against a case for reasons of consideration and application of criminal acts as an effort to apply the last legal sanctions. based on explaining and knowing the reasons and considerations of the Immigration Office Class I TPI Banda Aceh providing Immigration Administrative Actions against Yousuf Karim Immigration law enforcement begins with important matters regarding immigration instruments, namely immigration matters which consist of a series of supervision of the crossing of people entering and leaving the territory of Indonesia. and a series of surveillance of foreigners in the territory of Indonesia, then the Immigration Officer has the right of authority in terms of giving Immigration Administrative sanctions against foreigners who are in the territory of Indonesia who carry out dangerous activities and are reasonably suspected of endangering security and public order or not respecting or disobeying the law enforcement
Study About The Establishment Of Immigration Office Unit In Gadjah Mada University Before And After Authorized Decision Letter By The Director General Of Immigration Number: Imi-0003.Pb.02.09 2021
Authors: Bellisima Olivia Bianca Chintya , Purwanti Maidah , Syahrin M. Alvi
Published: October 2023

Immigration Office Unit in Gadjah Mada University is one of the breakthroughs in helping Immigration duties and Immigration functions by Class I Immigration Office Yogyakarta. Immigration services at that Immigration Office Unit has started since November 25th 2020 (soft launching). Nevertheless, from November 25th 2020 until June 3rd 2021 the authorized decision letter by the director general of immigration related to establishment of Immigration Office Unit in Gadjah Mada University based on article 8 section 1 letter h Director General Immigration Regulations Number: IMI-0746.OT.01.01 2017 about Technical Procedure Establishment of Immigration Office Unit has not been released. Hereafter, this research is to find out how is the role of Immigration Office unit in Gadjah Mada University to support immigration services in Class I immigration Office Yogyakarta and how is the legality of the immigration documents which have been released. The research method is using normative-empirical. As the result, the immigration documents which have been released by that Immigration Office Unit at that period didn’t disturb the legality of documents. However, to make sure that conclusion is strong enough, thing that needed to be done is changing the authorized decision letter about Immigration Office Unit in Gadjah Mada.
ANALYSIS AND INITIATION OF EFFORTS TO EXTERMINATE ILLEGAL INDONESIAN MIGRANT WORKERS SYNDICATE THROUGH COLLABORATION OF THE INDONESIAN MIGRANT WORKERS PROTECTION AGENCY AND THE DIRECTORATE GENERAL OF IMMIGRATION
Authors: Gibran Atsil Syah , Khusairy M Fadly
Published: October 2023

The Indonesian Migrant Worker Protection Agency (BP2MI) has made efforts to combat illegal placement of PMIs through outreach and regulatory adjustments. The number of PMI placements continued to increase, with 25,973 placements in May 2023 compared to 11,022 in May 2022 and 6,264 in May 2021. The majority of PMI placements in May 2023 were in the formal sector (55%) compared to the informal sector (45%). Efforts to impose sanctions BP2MI head of BP2MI has proposed firm action against illegal PMI placement syndicates, including cooperation with the immigration agency and the use of a special identity in PMI passports. Further research is needed to analyze and initiate efforts to eradicate illegal PMI syndicates through a review of the role of immigration, in order to address the challenges faced by PMI and the role of immigration authorities in combating illegal placements.
EDUCATIONAL ANALYSIS OF THE TEACHING OF PARENTING TRAINING (JARLATSUH) IMMIGRATION POLYTECHNIC IN ONLINE LEARNING AS AN OPTIMIZATION OF THE LEARNING SYSTEM
Authors: Hatta Hasibuan Moch Zidane , Itsar Muqarab Muhammad
Published: October 2023

Education is a crucial aspect, as mandated in the Constitution of the Republic of Indonesia. The application of education is generally different, but the goal is the same, namely, to educate the Indonesian nation. The Immigration Polytechnic, as a polytechnic under the auspices of the Ministry of Law and Human Rights, implements the Training and Care Lesson System (JARLATSUH). This learning system must be adaptable as a stimulant for the embodiment of industrial technology 4.0 COVID-19. The analysis that we did was to determine the effectiveness of applying online learning and solutions in developing the JARLATSUH learning system
AN EFFORTS TO PREVENT TERRORISM AS A TRANSNATIONAL CRIME THROUGH THE IMPLEMENTATION OF IMMIGRATION CONTROL
Authors: Gibran Atsil Syah , Hidayati Ully
Published: October 2023

The threat of terrorism in the world is increasing and the changes in tactics and strategies used by terrorist groups show the importance of international cooperation in fighting terrorism. Indonesia as a country with a strategic geographical location and abundant natural resources also faces the threat of terrorism. Movements of radical organizations such as ISIS, Al-Qaeda, and Jemaah Islamiyah have made Indonesia one of the targets for the spread of radicalism within the country. Therefore, supervision carried out by the immigration authorities plays an important role in controlling the potential for radicalism and terrorism. The Indonesian government has an obligation to protect sovereignty and maintain national integrity from threats both from within and from outside. Immigration as part of the government has a role in maintaining domestic security stability. In the context of immigration, strict monitoring of the movement of foreigners is very important in dealing with the threat of terrorism.
Isolated polymyalgia rheumatica: a cross-sectional, single-center, retrospective cohort study
Authors: TUNCER KURU Fatma , GÖKÇEN Neslihan , YAZICI Ayten , ÇEFLE Ayşe
Published: October 2023

Aim: The aim of the study was to review sociodemographic variables, clinical and laboratory findings, disease progression and treatment response of patients with isolated polymyalgia rheumatica and to investigate the effect of initial steroid dose and maintenance treatment on the progression of clinical and laboratory outcome.

Material and Method: The medical records of 39 polymyalgia rheumatic patients who followed up between 2001 and 2020 were screened. After excluding patients with overlapped giant cell arteritis and malignancies, 19 polymyalgia rheumatica patients (female:16 and male:3) were included in the study. Demographic data, anthropometric measurements, comorbidities, initial symptom, physical examination, clinical and laboratory (acute phase reactants) findings, medications, changes in treatment status, and cumulative steroid dose were recorded. The medical data of first (1st month), second (4th month), and third (7th month) visits were noted according to the structured form.

Results: The mean age was 68±8 years and the mean initial steroid dose was 21.5±8.9 mg. While the complaints regarding polymyalgia rheumatica decreased in 52.6% of patients (n=10) in the first visit, those complaints regressed in 47.4% (n=9) and 73.7% (n=14) of patients in the second and third visit, respectively. In the first visit (1st month), the mean erythrocyte sedimentation rate and C-reactive protein values were 21.7±12.3 mm/h and 5.8±5.1 mg/dl. In the second (4th month) and third visits (7th month), while the mean erythrocyte sedimentation rate was found as 36.5±27.3 mm/h and 27.3±18.6 mm/h, the mean C-reactive protein was 27.2±43.0 mg/dl and 17.6±30.2 mg/dl, respectively. Clinical remission was observed in 47.4% of patients (n=9) in the second visit and in 31.6% of patients (n=6) in the third visit. Median cumulative corticosteroid doses were 600 mg in first visit, 960 mg in second visit, and 1346 mg in the third visit.

Conclusion: The clinical characteristics and the initial steroid dose were compatible with the literature. Even though cumulative corticosteroid doses were quite high, lower remission rates were observed in these patients. The possible reason for this was considered to be the non-adherence of the patients to the treatment.
ASSOCIATION OF N-TERMINAL PROHORMONE BRAIN NATRIURETIC PEPTIDE LEVEL AND ECHOCARDIOGRAPHIC LEFT VENTRICULAR SYSTOLIC OR DIASTOLIC DYSFUNCTION IN NON-ACUTE DYSPNEA
Authors: KARACA ÖZER Pelin , AYDUK GOVDELI Elif
Published: October 2023

Objective: The aim of the study was to evaluate serum N-terminal prohormone brain natriuretic peptide (NT-proBNP) level and evidence of left ventricular (LV) systolic dysfunction (SD) or diastolic dysfunction (DD) in non-obese patients with non-acute dyspnea.

Methods: This study retrospectively evaluated the serum NT-proBNP level and LV SD or DD from transthoracic echocardiography (TTE) in patients with non-acute dyspnea between October 2020 and October 2021. The normal limit for the serum NT-proBNP level (125 pg/ml) was used as the cut-off value.

Results: Ultimately, 435 patients were included in the study. In 61% of the patients (n=264), the NT-proBNP level was elevated (≥ 125 pg/ml). There was no evidence of SD or DD in 56% of the patients (n=147) with ≥ 125 pg/ml. The patients whose NT-proBNP ≥ 125 but who had no SD or DD had a significantly higher H2FPEF score ≥ 6, atrial fibrillation, malignancy, previous COVID-19, and need for hospitalization than the patients whose NT-proBNP < 125 and who had no SD or DD (13% vs. 4%; 5% vs. 1%; 16% vs. 9%; 29% vs. 5%; and 25% vs. 11%, respectively). An NT-proBNP value < 752.1 pg/ml excluded SD with 72.5% sensitivity and 83.1% specificity and < 350.3 pg/ml excluded DD with 71.3% sensitivity and 75.5% specificity.

Conclusion: A high NT-proBNP value does not always indicate SD or DD. NT-proBNP measurement may detect not only overt heart failure but also subclinical LV dysfunction in various clinical entities, in addition to adding prognostic significance in non-acute dyspnea.
PREMATÜRELERDE KAN GRUPLARININ BRONKOPULMONER DİSPLAZİYE ETKİSİ
Authors: YILDIZ Duran , ÇAKIR Ufuk , TUĞCU Ali Ulaş , TAYMAN Cüneyt
Published: October 2023

Amaç: Özellikle prematüre bebeklerde ciddi solunumsal morbiditelere neden olan bronkopulmoner displazi ile kan grubu arasındaki ilişkisi bilinmemektedir. Çalışmamızda prematüre bebeklerde bronkopulmoner displazi ile kan grubunun ilişkisinin değerlendirilmesi amaçlanmıştır.

Yöntem: Çalışmamızda ünitemizde yatan ≤32 gebelik haftasında doğan prematüre bebekler retrospektif değerlendirildi. Tüm kan grupları bronkopulmoner displazi, demografik ve klinik özellikler açısından birbirleri ile karşılaştırıldı.

Bulgular: Çalışmaya O kan grubunda 110 (%31,1), A kan grubunda 155 (%43,8), B kan grubunda 63 (%17,8) ve AB kan grubunda 26 (%7,3) olmak üzere toplam 354 prematüre bebek dahil edildi. Kan grupları arasında bronkopulmoner displazi, demografik ve klinik özellikler açısından istatistiksel anlamlı fark saptanmadı (p>0,05).

Sonuç: Çalışmamızda kan grubu ve bronkopulmoner displazi ilişkisi gösterilememiştir. Prematüre bebeklerde bronkopulmoner displazi ile kan grubu arasında ilişki olup olmadığı halen bilinmemektedir.
The relationship between good collateral development and magnesium/phosphate ratio in chronic total occlusion
Authors: KIŞ Mehmet , ŞENÖZ Oktay , GÜZEL Tuncay
Published: October 2023

Objective: Coronary collateral formation can be triggered by many acquired factors such as ischemia and growth factors, which ultimately manifests as differences in the quality of the coronary collateral circulation (CCC) in patients. Low magnesium (Mg) levels can increase endothelial cell dysfunction and potentially increase the risk of thrombosis and atherosclerosis. However, it has been reported that high serum phosphate (P) levels are correlated with the development of atherosclerosis and mortality. In this article, we aimed to reveal the relationship between CCC quality and Mg/P ratio in chronic total occlusion (CTO).

Methods: A total of 269 patients with detected CTO in coronary angiography between March 2014 and June 2018 were included in the study. The patients were divided into two groups as group I (127 patients) and group II (142 patients) according to the Rentrop classification. The study is a retrospective, observational study.

Results: In the multivariable regression analysis; smoking (p=0.004), triglyceride (p
İSTANBUL VE ÇEVRESİNDEN ELDE EDİLEN GIDALARDAN İZOLE EDİLEN STAPHYLOCOCCUS AUREUS SUŞLARININ ÇEŞİTLİ ANTİBİYOTİKLERE KARŞI DUYARLILIKLARININ ARAŞTIRILMASI
Authors: ISSA Ghassan
Published: October 2023

Amaç: Bu çalışmada, İstanbul ve çevresinde bulunan çeşitli market, şarküteri ve semt pazarlarından toplanan 70 adet peynir, 70 adet yufka ve 10 adet çiğ süt olmak üzere toplam 150 gıda örneği Staphylococcus aureus (S. aureus) yönünden inceledikten sonra izole edilen S. aureus suşlarının antibiyotik duyarlılıklarını araştırılması amaçlandı.

Yöntem: Laboratuvara getirilen gıda örneklerinden kültürel yöntemlerini kullanarak S. aureus suşları izole edildi. S. aureus olarak tanımlanan suşların disk diffüzyon yöntemiyle her biri için 21 farklı antibiyotik diski kullanarak duyarlılıkları belirlendi.

Bulgular: Çalışmada analiz edilen 150 gıda örneğinden 10 (%6,66) adedi peynirden, 7 (%4,66) adedi yufkadan ve 2 (%1,33) adedi çiğ sütten olmak üzere 19 (%12,66) S. aureus suşu izole edildi. İzole edilen 19 S. aureus suşundan 3 (%15,78) tanesi birçok antibiyotiğe (Metisilin, Penisilin, Oksasilin, Ampisilin, Ampisilin Sulbaktam) dirençli olduğunu belirlendi.

Sonuç: Antibiyotik dirençli S. aureus suşları direkt temas yoluyla bulaşabileceği gibi hayvansal kökenli gıdaların tüketimi yoluyla da bulaşabilmektedir. Ülkemizde gerek tıp ve gerek veteriner hekimlik alanında antimikrobiyal direnç sorunu üzerinde entegre sörveyans sistemleri oluşturulmalı ve antimikrobiyal direnç olgusunun kontrolü için gerekli stratejiler geliştirilip uygulamaya konmalıdır.
Kocaeli Üniversitesi Araştırma ve Uygulama Hastanesi 2020 ve 2021 Yıllarına Ait Ölüm Kayıtlarının Değerlendirilmesi
Authors: GÜNER Mehmet Ertan , ÇAGLAYAN Çigdem
Published: October 2023

Amaç: Ölüm kayıtları epidemiyolojik değerlendirmeler için özel bir önem taşırlar. Bu araştırmanın amacı Kocaeli Üniversitesi Araştırma ve Uygulama Hastanesi’nde (KOÜAUH) 2020 ve 2021 yıllarında meydana gelen ölümlerin kayıtlar üzerinden değerlendirilmesidir. Yöntem: Tanımlayıcı tipte bir çalışmadır. KOÜAUH, 2020 ve 2021 yılı ölüm kayıtları veri kaynağı olarak kullanılmıştır. Toplam 1049 ölüm kaydı incelenmiştir. Araştırmanın incelenen değişkenleri kayıtlarda bulunan ölen hastanın yaşı, cinsiyeti, ölüm tarihi, ölüm nedeni ve ölümün gerçekleştiği bölümdür. Bulgular: 2020 yılında, 30.178 hasta yatırılmış, 552 ölüm gerçekleşmiş; 2021 yılında 39.151 hasta yatırılmış, 497 ölüm gerçekleşmiştir. Buna göre 2020 ve 2021 yıllarında hastane mortalite hızı sırasıyla; binde18,29 ve binde12,69 olarak hesaplanmıştır. Ölüm sayıları, aylara göre incelendiğinde COVID-19 nedenli ölümlerin Ekim 2020 ile Şubat 2021 arası dönemde pik yaptığı görülmüştür. Ölümlerin gerçekleştiği birimlere bakıldığında 2020 ve 2021 yıllarında sırasıyla %48,4 ve %57,9 ile erişkin yoğun bakım üniteleri ilk sırada gelmektedir. Ölümlerin, 2020 yılında %25,4 ve 2021 yılında %26,8 ile en yüksek oranda COVID-19 nedeniyle gerçekleştiği görülmüştür. 2020 yılında COVID-19 nedenli ölümlerde yaş ortalaması (66,96±15,85), COVID-19 dışı nedenli ölümlerin yaş ortalamasına (55,75±26,62) göre istatistiksel olarak anlamlı düzeyde yüksek görülmüştür. (p 0,000, Mann-WhitneyU testi). Sonuç: 2020 ve 2021 yıllarında hastanede gözlenen ölümlerde cinsiyet ve yaş dağılımının benzer olduğu görülmüştür. Ancak COVID-19 özelinde ölümlerin anlamlı derecede ileri yaş grubunda meydana geldiği görülmüştür. Her iki yılda da ölümler en sık olarak yoğun bakım ünitelerinde meydana gelmiştir. KOÜAUH’de ölüm nedenleri içinde her iki yılda da COVID-19 nedenli ölümler ilk sırada yer almıştır. Tanımlayıcı bir çalışma olarak bulgular üzerinden nedensellik kurulamasa da ölümlerin dağılımı özellikle pandemi süreciyle ilgili fikir vermektedir.
Capsaicin attenuates bupivacaine anesthesia-induced neurotoxicity in SH-SY5Y cells by regulating apoptosis
Authors: ALTUN Ahmet
Published: October 2023

Objective: Bupivacaine administered for local anesthesia can cause critical neurotoxicity and neurological dysfunctions. Any substance that can reduce bupivacaine-mediated toxic effects will be of great interest during surgical procedures and in the pain management process. In this context, we evaluated capsaicin, an alkaloid of Capsicum annuum (cayenne pepper), which has been intensively researched for its neuroprotective effect due to its various biological effects such as cardioprotective, antiinflammatory, analgesic, thermogenic, and benefits on the gastrointestinal tract.

Methods: In this study, we researched the in vitro effect of capsaicin in SH-SY5Y cells with a model of bupivacaine-mediated neurotoxicity. Cell proliferation assay was handled by XTT, and apoptosis was determined by flow cytometry analysis.

Results: We observed a notable increase in apoptosis induction with a significant decrease in the viability of cells exposed to bupivacaine at 1 mM. We found that bupivacaine-mediated cytotoxicity was reduced when increasing concentrations of capsaicin were applied to bupivacaine-treated cells. At the same time, capsaicin also reduced apoptosis in SH-SY5Y cells exposed to bupivacaine.

Conclusion: According to our results, it is thought that the administration of capsaicin against bupivacaine-mediated neurotoxicity may be an alternative neuroprotective agent by suppressing the apoptosis response in neurons.
Subakromiyal Sıkışma ve Nervus Suprascapularis Sıkışması Sendromları ile İlişkili Scapula Morfometrik Özellikleri
Authors: ERÇALIK Cem , ERTAŞ Ahmet , ÜZEL Mehmet , TANYELİ Mahmut Ercan , SOYLUOĞLU Ali İhsan
Published: October 2023

Amaç: Subakromiyal sıkışma ve nervus suprascapularis sıkışması sendromları ile ilişkili olabilen scapula morfometrik özelliklerini incelemek.

Gereç ve Yöntem: Anatomi Anabilim Dalı laboratuvarında bulunan, yaşı ve cinsiyeti belirsiz, toplam 71 adet scapula çalışmaya dahil edildi. Scapula’lar incisura scapulae şekline göre ve acromion alt yüzeyinin eğimi ve şekline göre tiplere ayrıldı. Buna ek olarak Incisura scapulae -tuberculum supraglenoidale, acromion-tuberculum supraglenoidale ve acromion- processus coracoideus arasındaki mesafe ölçüldü.

Bulgular: Incisura scapulae şekillerinden J tipi en fazla (%36,6) görülürken, en az oranda foramen tipine (%4,2) rastlandı. Acromion’lar alt yüzey eğimlerine göre sınıflandıklarında, en sık Tip I (düz) acromion (%69), acromion’lar şekillerine göre sınıflandırıldıklarında ise en sık tip 2 (kare) tipi (%38) saptandı. Incisura scapulae -tuberculum supraglenoidale arasındaki mesafe ortalama 31.97±3.08 mm, acromion-tuberculum supraglenoidale arasındaki mesafe ortalama 24,7±3,97 mm, acromion- processus coracoideus arasındaki mesafe ise ortalama 33,1±5,53 mm olarak bulundu. Bu mesafelerin incisura scapulae tiplerine göre değerlendirilmesinde ise istatistiksel olarak anlamlı bir sonuca rastlanmadı.

Sonuç: Scapula morfometrik özelliklerinin belirlenmesi klinikte subakromiyal sıkışma ve nervus suprascapularis sıkışması sendromlarına daha iyi ışık tutabilir.
Serbest fetal DNA fraksiyonu plasental problemlere bağlı gebelik sonuçlarında değişir mi?
Authors: AKAR Bertan , KÖLE Emre , ÖZCAN Canan , ÇAKIR KÖLE Merve
Published: October 2023

Amaç: Cff-DNA’nın non-invazif tanı uygulamaları dışında, bu biyobelirtecin preeklampsi, IUGR, preterm doğum gibi önemli obstetrik komplikasyonları belirlemede yerini araştırmak.

Yöntemler: Çalışmamız eylül 2019-mart 2020 tarihleri arasında, kliniğimize başvuran 10-24. Gebelik haftaları arasında kendi isteği, ileri anne yaşı olan (≥40) ve ikili testte artmış trizomi 13, 18 ve 21 riski nedeniyle serbest fetal DNA analizi (HarmonyTM Prenatal Test; Ariosa Diagnostics Inc., San Jose, Calif., USA) yapılan 131 hastalarda tek merkezli retrospektif çalışma olarak planlandı.

Bulgular: Çalışmamızda hastaların 10’ unda (%8,1) oligohidramnios, 10’ unda (%8,1) gestasyonel diyabet, 7’ sinde de (%8,6) preeklampsi gözlenmiştir. 2 hastada da (%1,2) dekolman plasenta izlenmiştir. 10-24. gebelik haftaları arası ölçülen hücre dışı fetal DNA fraksiyonlarının artmış düzeyleri IUGR ile sonuçlanan gebelikleri öngörmede anlamlı bulunmuştur (p< 0.01). Diğer gebelik sonuçları ( preeklampsi, GDM, preterm eylem, oligohidroamnios, dekolman plasenta ) ve hücre dışı fetal DNA fraksiyon düzeyleri ile anlamlı ilişki bulunamamıştır.

Sonuç: Cff-DNA’nın prenatal taramada bir dizi değerli uygulamaya sahiptir ancak gebelik komplikasyonlarını öngörmede cff-DNA’nın düzeyleri ile ilişkisi klinik uygulamada henüz yeri netleşmemiştir. Bu nedenle çalışmalar, cff-DNA’nın potansiyel öngörüsü ve tanısal uygulamalarını belirlemek için gebelikteki patolojik koşullar altındaki düzeylerinin belirlemesini amaçlamalıdır.
Inhibitory Effect of Cell Phones Against Human Breast Cancer and Myeloid Leukemia Cells Proliferation in Culture Media
Authors: BOĞA Bircan , AKBULUT Merve , MAYTALMAN Erkan , KOZANOĞLU İlknur
Published: October 2023

Objective: There is current news that emerges regarding the relationship between the magnetic effects of cell phones and some types of cancer. In spite of the studies carried out, the level of evidence of this news is low, and also the relationship between the magnetic effects of cell phones and other types of cancer is not certain except for brain cancer. In this study, it is aimed at examining the effects of magnetic field of cell phones on the samples of breast cancer human myeloid leukemia cell growth.

Methods: In the study, breast cancer MCF-7 and leukemia K562 cell lines were used as the source of cancer cell. During the six-day cell culture, cancer cells were subjected to the effects of cell phone by using a telephone call program (Automated outbound call software). The system made 6 calls for 1 minute for each call once in 144 minutes from fixed line. The number of cultured cells and proliferation capacities of the two types of tumor cells in the control and experimental groups were assessed.

Results: The number of cancer cells, which were subjected to the effects of cell phone as a result of the culture of tumor cells, was found lower when compared with control group (7500000 ± 100000 vs 6625000 ± 225000 for MCF-7; 15412500 ± 112500 vs 13700000 ± 250000 for K562; P < 0.05 for both). In MTT test, it was found out that two types of cell proliferation was inclined to slow down with the effect of cell phone.

Conclusion: The results can be translated that cell phone may inhibit neoplastic transformation, and this observation may promote to initiate a new clinical studies both for healthy people and for patients with cancer.
KEEP IN MIND OTHER CAUSES THAN INTRINSIC SPHINCTER DYSFUNCTION IN POST-PROSTATECTOMY INCONTINENCE
Authors: YILDIZ Hüseyin Alperen , SOGUTDELEN Emrullah
Published: October 2023

Objective: This study aims to determine the causes of urinary incontinence and accompanying bladder pathologies in patients with persistent incontinence 12 months after radical prostatectomy.

Methods: Thirty-four patients who underwent open radical retropubic prostatectomy (RRP) due to localized prostate cancer and incontinent after surgery between January 2015 and December 2020 and underwent urodynamic study (UDS) were retrospectively reviewed. All UDSs were performed according to the ICS protocol of good urodynamic practice and assessed by the same doctor. Patients were assessed by demographic and clinical parameters including age, body mass index (BMI), comorbidity, preoperative PSA level, prostate volume (PV), transrectal prostate biopsy Gleason score, clinical stage, pathological ISUP grade, pathological stage, lymph node positivity, international consultation on incontinence questionnaire-short form and subjective questionnaire for daily pad use.

Results: Urodynamic studies showed that 29 patients (85.2%) had intrinsic sphincter deficiency (ISD). Nine (26.4%) of 29 patients with ISD had a secondary diagnosis of overactive bladder (OAB), impaired detrusor contractility (IDC) and OAB+IDC 9 (11.6%), 4 (11.6%), 1 (2.9%), respectively. Nineteen patients (55.8%) had a sole diagnosis of ISD, whereas 15 patients (44.1%) had another primary diagnosis or a secondary diagnosis other than ISD.

Conclusion: Although ISD is the most common cause of persistent urinary incontinence in patients after radical prostatectomy, it should be taken into account that overactive bladder and impaired detrusor contractility are also accompanied by a significant proportion of patients.
Antibiotic resistance of acinetobacter strains in our intensive care unit : a retrospective study
Authors: KARAKOÇ Ebru , AYYILDIZ Ayşe , YELKEN Birgül
Published: October 2023

Objective: Antibiotic resistance development in the treatment of acinetobacter infection is a serious health care problem and responsible for high mortality in intensive care units (ICU). In our study, it was aimed to determine rates of antibiotics resistance of Acinetobacter strains isolated from various samples in our ICU.

Methods: We examined the records of acinetobacter isolates and antibiotics resistance for one year follewed up in our ICU. The samples from different patients and different type of samples of the same patients were evaluated.The data was analyzed with SPSS for Windows version 23.0. Categorical variables were expressed in terms of numbers and percentage.

Results: 50% of the samples were isolated from tracheostomy.96.4% of the 138 isolates were A. Baumanii and 3.6% were the other strains.We found high resistance to all of antibiotics except colistin(3.6%) and tigecycline (13.1%).

Conclusion: Acinetobacter is the most important opportunistic human pathogen causing fatal nosocomial infections because of its ability of develop resistance new antibiotics overly fast. Compared to the results reported from Dicle University Hospital in south east of our country it seems that antibiotics especially cholistin resistance ratio in our ICU is different. It is important to remember that antibiotic susceptibility may vary in regions, hospitals even clinics, and resistance development should be constantly detected to make the appropriate initial therapy until deescalation.
Assessment of endothelial dysfunction and vascular stiffness after cholecalciferol according to dialysis modality
Authors: AYTAC Mehmet Baha , ÖZGÜR Merve Aktaş , DOĞAN Kenan , DEVECİ Murat , KAYABEY Özlem , BEK Kenan
Published: October 2023

ABSTRACT

Objective: The risk of developing cardiovascular disease (CVD) increases significantly in children with chronic kidney disease (CKD) especially with low serum 25- hydroxyvitamin D (25OHD) levels. Herein; we aimed to compare the effects of vitamin D deficiency and the impact of cholecalciferol treatment on endothelial functions and vascular stiffness in children with CKD receiving hemodialysis (HD), peritoneal dialysis (PD) and non- dialysis(ND).

Methods: 7 HD, 7 PD and 27 ND patient groups consisting of 41 children totally with low 25OHD levels were compared among each other in regards of biochemical parameters, flow-mediated dilatation(FMD) and local arterial stiffness before and after a single dose of 300.000 units of cholecalciferol treatment.

Results: There was no difference in FMD and local arterial stiffness values between HD, PD and ND patient groups before vitamin D supplementation. Significant increase in endothelium-dependent FMD was observed in all patient groups after intervention with cholecalciferol; however the improvement in endothelium-independent FMD and local arterial stiffness measurements was demonstrated in patients with PD and ND. Baseline parathormon level was higher in patients on dialysis; at the end of the study, significant decrease was detected only in patient group not receiving diaysis.

Conclusions: Endothelial dysfunction and impaired vascular stiffness were determined in children with CKD with low 25OHD levels regardless of the disease severity.. Recovery with cholecalciferol therapy revealed that vitamin D deficiency should be corrected even in early stages of CKD to prevent the development of CVD
Elektif Koroner Arter Bypass Cerrahisinde Traneksamik Asit Uygulama Tekniğinin Etkinliği
Authors: İNDELEN Cenk
Published: October 2023

Amaç

Bu çalışmanın amacı, elektif koroner arter bypass cerrahisi geçiren hastalarda traneksamik asitin kardiyopulmoner bypass öncesi ve sonrası uygulanmaya başlanmasının etkilerini değerlendirmektir. Birincil güvenlilik son noktası, ameliyat sonrası yoğun bakım erken miyokart enfarktüsü, inme, tromboemboli (arteryal/venöz) olayları değerlendirmektir. Birincil etkinlik son nokta, eritrosit süspansiyonu transfüzyonu miktarı ve yoğun bakım kalış süresine etkiyi ölçmektir.

Yöntem

Ocak 2002 ile Aralık 2007 yılları arasında 3729 izole elektif koroner arter bypass greft operasyonu retrospektiftif olarak incelendi. 300 hasta çalışmaya dahil edildi. Örneklem büyüklüğü her grupta 100 hasta olacak şekilde oluşturuldu. Grup 1 kontrol grubuna traneksamik asit uygulaması yapılmadı, Grup 2 cerrahi insizyondan 20 dakika önce traneksamik asit 30mg/kg bolus dozunda uygulandı ve kardiyopulmoner bypass sonunda, protamin verilmesi bittikten 10 dakika sonra 10mg/kg dozunda başlandı, 4 saat infüzyon ile verildi. Grup 3 kardiyopulmoner bypass sonunda, protamin verilmesi bittikten 10 dakika sonra traneksamik asit 30mg/kg bolus dozunda uygulandı ve 10mg/kg dozunda başlandı, 4 saat infüzyon ile verildi. İstatistiksel olarak ANOVA analiz,post hoc Tukey HSD, Pearson chi kare, Fisher’s exact yöntemleri kullanıldı.

Bulgular

Traneksamik asit uygulama farklılığı postoperatif kanama miktarını anlamlı etkisi olmadı. Yoğun bakım kalış süresini etkilemedi. Kardiyopulmoner bypass sonrası traneksamik asit uygulamasının eritrosit transfüzyonunda olumlu anlamlı etkisi oldu. Ancak aynı grupta ciddi bir komplikasyon olan inme daha sık görüldü.

Sonuç

Traneksamik asit uygulama ve dozları ile ilgili ortak bir klinik yaklaşım yoktur. Kılavuzlar transüzyon miktarının azaltılması ve “Hasta Kan Yönetimi” uygulamaları için traneksamik asit kullanımını önermektedir. İnme komplikasyonu tedirgin edicidir
Pulmoner Hydatid Cyst Surgical Treatment, Single Center Experience
Authors: ELİCORA Aykut , SEZER Hüseyin Fatih
Published: October 2023

Objective: Lung hydatid cyst is an infectious disease caused by the parasite Echinococcus granulosus. Surgery is the main treatment of the disease in lung hydatid cysts. In our article, we aimed to share our experiences with our patients who underwent surgical treatment for hydatid cysts of the lungs.

Methods: The data of 41 patients who underwent surgical treatment for pulmonary hydatid cysts in our clinic were analyzed retrospectively. The factors affecting the success of surgical treatment were analyzed.

Results: Eighteen (43.9%) of the patients were male and 23 (56.1%) were female. There was no statistically significant difference between the size groups in terms of length of hospital stay (p=0.070). No statistically significant correlation was found between the number of lesions and postoperative complications (p=0.367).

Conclusion: Lung hydatid cysts are a public health problem that can be seen in all age groups. Although different symptoms and complications related to the disease are encountered in lung hydatid cysts, surgery is an effective treatment method with low recurrence, morbidity and mortality.
Use of Stage V compliant engine in modernized SM42 diesel locomotive
Authors: Frankowski Maciej , Cichoński Zbigniew , Stępniewski Łukasz , Andrzejewski Maciej
Published: October 2023

The article presents the result of modernization of the SM42 locomotive carried out by H. Cegielski Fabryka Pojazdów Szynowych from Poznań (Poland). The scope of modernization was discussed and the parameters of the locomotive before and after the introduced changes were presented. The new engine used in the locomotive was described and its parameters confirming the fulfillment of the requirements of the STAGE V standard were presented. Moreover, further development opportunities for the SM42 6D-FPS locomotive were discussed.
Triple Jump Ability: The Effect Of Single Leg Speed Hop Training Method on High School Students
Authors: FADHOLI M. NUR
Published: October 2023

The  purpose  of  the study. This research was motivated by the results of the triple jump carried out by the students of class X SMAN 2 Tapung Hilir not optimal and less precise in its implementation. The triple jump is an athletic sport in the form of jumping, lifting the legs up and forward in an effort to carry the point of weight as long as possible in the air.
Materials and methods.. Methods This research uses an experimental method with One Group, namely Pre-test and Post-test Design. The data collection technique was saturated sampling with inclusion and exclusion criteria. Data analysis in this study used the Wilcoxon test, Paired Sample T-test.
Results. Data analysis in this study used the Wilcoxon test, Paired Sample T-test. Research results based on the statistical output "Test Statistics", it is known that Asymp.Sig (2-tailed) is worth 0.001. Because the value of 0.001 is smaller than <0.05.
Conclusions. The conclusion in this study is that there is a significant effect between the single leg speed hop exercise method and the triple jump ability of the students of SMAN 2 Tapung Hilir.
Reformulasi Kurikulum Pendidikan Agama Islam: Suatu Keharusan di Era Digital
Authors: Muthrofin Khoirul , Madekhan Madekhan
Published: October 2023

Era globalisasi atau era digital telah membawa serangkaian perubahan yang fundamental dalam berbagai aspek kehidupan manusia. Berbagai aktifitas pekerjaan manusia beralih menjadi serba digital sebab adanya teknologi yang canggih, yang memungkinkan manusia mengakses informasi secara luas dan tidak terbatas ruang mauun waktu. Pendidikan Islam diharapkan mampu melakukan upaya pengembangan untuk menjawab problematika yang muncul dan agar tetap survive menghadapi tantangan era digital. Tujuan penelitian ini adalah untuk memberikan uraian tentang upaya pendidikan Islam dalam melakukan reformulasi kurikulum PAI sebagai respon terhadap tuntutan dan kebutuhan masyarakat di era digital. Metode yang digunakan dalam penelitian adalah studi kepustakaan atau library research, yang dilakukan terhadap sumber-sumber data penelitian yang terkait. Data penelitian diambil dari jurnal ilmiah yang didapatkan dari akses google schoolar, buku-buku tentang kurikulum dan Pendidikan Agama Islam, dan artikel lain yang memiliki keterkaitan dengan kajian penelitian. Hasil penelitian mengungkapkan bahwa perlu adanya upaya reformulasi kurikulum PAI yang ideal dalam merespon kebutuhan dan tantangan kemajuan zaman. Pendidikan Islam memegang peran penting dalam menyiapkan generasi muslim yang unggul, berkualitas, dan memiliki kompetensi pendidikan abad ke-21.
Pengembangan Media Pembelajaran Scrapbook untuk Meningkatkan Hasil Belajar Siswa
Authors: Khoirin Lukman
Published: October 2023

Rendahnya minat belajar siswa dalam pembelajaran karena kurangnya pemanfaatan media berakibat pada kurangnya peningkatan hasil belajar siswa. Penelitian ini mengembangkan media scrapbook untuk meningkatkan hasil belajar pada pembelajaran matematika materi bilangan pecahan .Penelitian ini bertujuan untuk meningkatkan hasil belajar pada pembelajaran matematika materi bilangan pecahan denagn menggunakan media scrapbook di kelas  III SD Islam Darussalam Kedungrejo Sumberrejo. Media scrapbook adalah salah satu media pembelajaran jenis 3 dimensi. Media ini berupa handmade yang dibuat dari kertas asturo maupun kertas karton. Subjek penelitian ini yaitu seluruh siswa kelas III SD Islam Darussalam Kedungrejo Sumberrejo dengan jumlah 39 siswa 18 laki-laki dan 21 perempuan . Penelitian ini menggunakan penelitian tindakan kelas dengan model desain Kemmis & Mc. Taggart, Teknik pengumpulan data pada penelitian ini adalah observasi, tes, dokumentasi. Hasil penelitian pra siklus mendapatkan persentase sejumlah 45,15%. Dan siklus pertama mendapatkan persentase sejumlah 57,35% pada siklus kedua mendapatkan persentase sejumlah 73,25%. Dapat disimpulkan bahwa  hasil penelitian pengembangan media scrapbook dalam pembelajaran matematika materi bilangan pecahan dapat meningkatkan hasil belajar kelas III SD Islam Darussalam Kedungrejo Sumberrejo. Media pembelajarannya juga dapat diterima siswa terbukti dengan semangat siswa dan respon siswa.
Performance Evaluation of Face Recognition System (FRS) Developed with Haar Cascade and MongoDB Integration in Recognition of Covered Faces
Authors: Yıldız Anıl , Güney Zafer , Aydın Hakan
Published: October 2023

Although traditional face recognition systems (FRS) can detect with a certain success rate whether a mask is worn, they may fail due to the fact that most of the faces of the people who wear masks are covered. The difficulties arising from the fact that a significant part of the faces of individuals wearing masks are covered limits the performance of existing FRSs. In this research, it is aimed to integrate the Haar Cascade method with the MongoDB database in real time using the OpenCV library for mask-wearing face recognition and to demonstrate its performance with extensive experiments. In the experiments, the data set created within the scope of this study from realistic face images, in which most of the masked faces are covered, was used. Our research has shown that the accuracy of face recognition is 85% for masked faces, 61% for unmasked faces, and 41% when half of the face is covered by a different object. It is considered that this study will contribute to the literature in terms of providing a more effective and applicable mask detection solution by combining the Haar Cascade method with real-time database management integration.
CONVERSION OF LAPAROSCOPIC APPENDECTOMY TO OPEN APPENDECTOMY IN CHILDREN REASONS AND CLINICAL OUTCOMES
Authors: KHAN MJ , KARAMATULLAH . , ULLAH I , KHAN MQ
Published: October 2023

This study was carried out To assess the impact of this conversion on clinical outcomes to better understand the reasons for pediatric patients' open appendectomy procedures as opposed to laparoscopic ones. This medical research study is retrospective. We conducted a retrospective study of pediatric patients (ages 1 to 18) who had appendicectomies at MMC Mardan's Department of Pediatric Surgery between January 2010 and December 2020. Patient demographics, preoperative presentation, surgical technique (open or laparoscopic), conversion reasons, intraoperative findings, postoperative problems, duration of hospital stay, and follow-up results were all recorded. The statistical analysis included logistic regression analyses, t-tests, and chi-square tests when appropriate. The research included 462 pediatric patients, of whom 268 had a laparoscopic appendectomy, and 194 underwent open appendectomy. In 56 patients (20.9%), laparoscopic Conversion to open appendectomy was necessary. The most frequent causes of Conversion were adhesion-related vision difficulties (33.9%) and complex appendicitis (46.4%). Compared to patients who had a successful laparoscopic operation, those who had laparoscopic-to-open Conversion had a substantially greater risk of postoperative problems (24.1% vs. 8.2%, p < 0.001) and longer hospital admissions (mean 4.7 vs. 2.9 days, p < 0.001). The results of a logistic regression study showed that older age (OR 1.22, 95% CI 1.06-1.41) and complex appendicitis (OR 3.14, 95% CI 1.56-6.33) were independent predictors of Conversion. In children, complex appendicitis and intraoperative complications often need Conversion from laparoscopic to open appendectomy. Extended hospital stays and a greater incidence of postoperative complications are linked to these patients. Optimizing results and reducing the need for Conversion need a surgeon with extensive training and expertise in patient selection.