bluuebunny/crossref_metadata_2025 huggingface dataset:
The Effect of Wellness Programs on Long-Term Contract Employees' Workplace Stress, Absenteeism, and Presenteeism
Authors: Valentine Desree S. , Ferebee Susan , Heitner Keri L.
Published: September 2021

The quasi-experimental study reported in the present article is aimed at increasing the understanding of the effects of long-term contract employees participating in wellness programs. The reported study examines the effect (if any) that a wellness program has on workplace stress, absenteeism, and presenteeism for long-term contract employees participating in a wellness program. A one group pretest-posttest design was used. Convenience sampling was conducted in a hospital in the New York City Metro area. Data was collected from 19 participants. Paired sample t-test and a Wilcoxon signed-rank test were used to determine if there was a significant statistical difference before and after a dance aerobic exercise intervention. The instruments used to gather data were the Perceived Stress Scale (PSS) and the World Health Organization Health Performance Questionnaire (HPQ). The results indicated a statistical difference for workplace stress, but no statistical difference for absenteeism and presenteeism.
Leisure and Wellness Perceptions of Tourism Workers in Work-Life Balance
Authors: Yürcü Gülseren , Çolakoğlu Ülker
Published: September 2021

In this study, the concepts related to leisure and wellness perceptions will be discussed in order to provide the work-life balance of tourism workers. With a descriptive analysis, it will be discussed how leisure time evaluation and wellness perception contribute to the work-life balance of tourism employees as strategies to cope with work and non-work problems. The fact that the work-life balance of tourism employees is at an optimum level is of great importance for the tourism industry where business factor and service quality are critical. Factors such as uncertainty environment, low labor morale, and high turnover rate constitute the general business life characteristics of tourism employees. As a result, the effect of leisure and wellness perceptions of tourism employees on coping with these factors and establishing work-life balance will be discussed in the light of related literature.
Work Role Stress and Employee Outcomes
Authors: Chhabra Bindu
Published: September 2021

Work Stress is taking its toll on the working adults and the evidence of its detrimental effects is building in India as in United States and other developed countries. Research has shown that the work stress can lead to physical and psychological disorders that reduce job performance and negatively affect other employee outcomes. The purpose of the study was to examine the direct effect of work role stress on job satisfaction and two dimensions of employee outcomes i.e., organizational citizenship behaviour (OCB) and turnover intention in the Indian organizations. The study further aimed to investigate the mediating role of job satisfaction in the relationship between work role stress and two employee outcomes, i.e., organizational citizenship behaviour and turnover intentions. Data, using a structured questionnaire comprising the standard scales for work role stress, job satisfaction, organizational citizenship behaviour and turnover intentions, was collected from a diverse range of organizations in Delhi and NCR.
Work Stress and Psychosocial Factors in the Manufacturing Industry
Authors: Hernández Mónica Gabriela Gutiérrez , Martínez Rosa María Reyes , Maldonado-Macias Aide Aracely , Leal Jaime Sánchez , Rodríguez Jorge De La Riva
Published: September 2021

Companies are in constant search of greater productivity and better use of resources; however, they have neglected the human being. In this regard, it is important to analyze the presence of the psychosocial factors to which workers are exposed at all levels. These factors exert both a positive and a negative influence and indeed turn into a risk when they are not in balance with worker capabilities. This literature review aims to provide a comprehensive understanding of the psychosocial factors present in the manufacturing industries. The methodology consisted of conducting a search in two databases in addition to government pages. A combination of keywords was used for the search, and each publication was classified according to the factors analyzed, the type of evaluation, and the area of application. Out of all 2,468 publications found, eight were selected. Finally, work-related psychosocial factors were found to be the most analyzed.
Exploring Blue- and White-Collar Employees' Well-Being at Work System
Authors: Vayrynen Seppo Tapio , Kiema-Junes Heli Katariina
Published: September 2021

The aim of this study was to examine occupational group-related differences in well-being at work (WBW) indicators ranging from real accidents, absences and retirement to experienced pleasure at work. Occupational group included two categories: blue- and white-collar employees. The study is based on analysing national statistics or ones of various industrial sectors (Study 1), or bases on findings of questionnaires in Finnish case companies (N=7) (Studies 2 and 3). WBW questionnaires answered by 3500 employees. Analysis utilised data that employees of two occupational groups, or company and national statistics revealed about WBW. Analysis was based on factors related to employee, task, tool, organisation and work environment (traditional work system (WS)), psychosocial factors, and information and communication within WS. The biggest and statistically significant differences were emphasised in results and discussion. Although two groups' roles and tasks provide reasons for many differences, the ones should be measured, thoroughly discussed and consciously managed.
Management of Intercultural Relations in an Intercultural Organization
Authors: Vargas-Hernández José G. G. , Poulose Jeanne
Published: September 2021

The chapter aims to reflect on the management of intercultural organizational relations. It explains the transition of homogenous organizations into the culturally heterogeneous organization and compares multiculturalism with cross-culturalism in its ability to harmonize the principles of cultural diversity with universal ethical principles. It explores the process of creation of a third culture to foster understanding and acceptance among diverse teams. It attempts to establish the impact of intercultural interactions/relations on the effectiveness of a diverse team of individuals interacting in concert to achieve common goals. The work also underpins some analysis of the creation, development, and management of organizational intercultural capital. Finally, the emergence of the model of strategic management of an intercultural organization focused on learning and training for proper operationalization and implementation is proposed, and some challenges that could antagonize the teams are looked into and proposals are formulated.
Veterans Should Be Included Too
Authors: Hunter-Johnson Yvonne O.
Published: September 2021

The transitioning of veterans from the military world to the civilian world and by extension the civilian workforce is a critical career transition. Despite their motivation and resilience, veterans still encounter a multiplicity of challenges when transitioning to the civilian workforce, which quite often has a rippling impact on their attainment of employment, job retention, and career development within the civilian sector. An added layer to the transitional challenge for veterans is organizational resistance to promote diversity and inclusion policies and practices, specifically regarding veterans. On this premise, this chapter aims to: 1) Discuss the transitional challenges of veterans to the civilian workforce and 2) Provide implementation strategies at an organizational level to promote diversity and inclusion, specifically regarding veterans.
Gender Diversity in the Senior Management of Large Technology Companies
Authors: Fernández-Torres Yakira , Palomo-Zurdo Ricardo Javier , Gutiérrez-Fernández Milagros
Published: September 2021

As a key part of the fourth industrial revolution, technology companies have become the most valuable companies in the world in terms of market capitalization. Surprisingly, however, these companies have been overlooked by studies of gender diversity in corporate governance even though their highly distinctive features may cause major differences in gender diversity with respect to companies in other sectors. The goal of this chapter is therefore to provide the first characterization of gender diversity in the corporate governance of large technology companies—specifically those with the highest market value—and explore the relationship between gender diversity and business performance. To achieve this goal, descriptive statistical analysis is used. Data correspond to the period 2005 to 2017. The findings confirm the under-representation of women on the boards of directors of 162 publicly listed companies. The findings also show that the most profitable companies are those that have the greatest female representation on their boards of directors.
Trends in Macroergonomics Applications for Improved Work Systems
Authors: Arredondo Karina Cecilia , Realyvásquez Arturo , Hernández-Escobedo Guadalupe
Published: September 2021

Macroergonomics is the subdiscipline of ergonomics that is concerned with the analysis, design, and evaluation of work systems. It means, macroergonomics focuses on harmonizing the organizational structure of a company and not only one workstation or one task, as microergonomics does. Macroergonomics is a top-down, middle-out, and bottom-up approach. In the top-down approach, the overall general work system structure may be prescribed to match the organization's sociotechnical characteristics. On the other hand, the middle-out approach focuses on the analysis of subsystems and work processes, which can be assessed both up and down the organizational hierarchy from intermediate levels, and also, up and down some changes may be done to ensure the work system design is harmonized. Finally, the bottom-up approach comprises an extensive participation of employees in the identification of problems. Currently, macroergonomics is considered an emergent subdiscipline, and there is the need to promote current theories and methods and propose new ones.
Sunflower and Linseed Oils with Decyl Methacrylate Based Copolymers as Green Lubricating Additives
Authors: Mohammed Ameen Hadi , Mahmood Tamador Ali , Yousif Selvana Adwar , Musa Aminu
Published: September 2021

During the last few years, the greener additives prepared from bio-raw materials with low-cost and multifunctional applications have attracted considerable attention in the field of lubricant industry. In the present work, copolymers derived from sunflower and linseed oils with decyl methacrylate were synthesized by a thermal method using benzoyl peroxide (BPO) as a radical initiator. Direct polymerization through the double bonds of the fatty acid chain in the presence of a free radical initiator leads to the formation of ecofriendly copolymeric additives (P1 and P2). The copolymers were characterized by Fourier Transform Infrared (FTIR) and Proton Nuclear Magnetic Resonance (1H-NMR). Thermal decomposition of copolymers was determined by thermogravimetric analysis. The average molecular weight was measured by gel permeation chromatography (GPC) method. Different concentrations of prepared copolymer as additives vis 1, 2, 3, and 4 (w/v) were used to examine the rheological behavior and performance evaluation of the formulated base oil. The copolymer acts as an excellent viscosity improver and better pour point depressant.
Walnut Shells as a Potential Fuel for Iron Ore Sintering
Authors: Kieush Lina , Koveria Andrii , Boyko Maksym , Hrubyak Andrii , Sova Artem , Yefimenko Vadym
Published: September 2021

Iron ore sintering is a predominant process for fine iron ore and its concentrate to be applied in the blast furnace process. However, sintering produces a negative impact on the environment. One of the effective ways to reduce greenhouse gas emissions from iron ore sintering is to use CO2-neutral biomaterials for the fuel needs of this technology. Walnut shells (WNS) are a promising raw material for such fuel substitute. Herein, the effect of the raw and the pyrolyzed WNS with a constant fineness of 3-0 mm on the sintering process and the sinter properties were studied. The proportion of WNS in the fuel composition was set to 25 wt.%. It has been established that the use of WNS pyrolyzed up to 873 K is optimal. Additionally, the difference in the reactivity of WNS and coke breeze has provoked the studies on the influence of the pyrolyzed WNS size on the sintering process. WNS size was set to 1-0, 3-0, 5-0, and 7-0 mm. It has been found that the most optimal both for the iron ore sintering process and the sinter quality is the use of WNS with a particle size of 3-0 mm, subjected to preliminary pyrolysis up to 873 K.
Stress Concentration in Bounded Compositeplates with Carbon Reinforcement
Authors: Maksymovych Olesia , Lazorko Aleksandr , Sudakov Andrii , Hnatiuk Oleksandr , Mazurak Andriy , Dmitriiev Oleh
Published: September 2021

The research purpose is to develop an approach for determining the stress concentration near the holes in composite structure elements reinforced with carbon fibres. The research is performed on the basis of a numerical-analytic approach using the method of singular integral equations. The paper studies the stress concentration near the holes in composite plate elements of the structures, which are reinforced with carbon fibres. The stresses are determined based on the singular integral equations. The integral equations are solved numerically using the mechanical quadrature method. The stress in the strip is studied at: longitudinal tension; pure bending; three-point bending; with periodically spaced holes. An approach to calculating the stresses in composite strips weakened by holes of different shapes, based on the method of integral equations, has been developed. The equation kernels are formulated on the basis of Green's functions, under which the boundary conditions on straight-line boundaries are satisfied identically. A methodology for calculating the stress concentration near the holes of arbitrary shape in plate elements of the structures has been developed. The results obtained can be used when calculating the strength of composite materials reinforced with carbon fibres.
Additive Manufacturing: A Layered Taxonomy and Classification for Material Engineering Process
Authors: Chike Onuchukwu Godwin , Ahmad Norhayati Binti , Al-Naib Uday M. Basheer
Published: September 2021

Material engineers continuously make every effort for the evolution of novel and prevailing production performances to supply our biosphere with resource-proficient, economical, and hygienic substances with superior package operation. The mitigation of energy depletion and gas releases as an utmost significance worldwide is a renowned datum; which also needs the improvement of delicate substances employing budget-proficient and ecologically pleasant methods. Consequently, copious exploration has been aimed in the study of methods retaining a potential to wrestle these widespread essentials. Material engineering processes have advanced as a feasible substitute for conventional steel fragment construction methods. CE has experienced an extraordinary advancement throughout the previous three decades. It was originally utilised uniquely as a state-of-the-art reserve of the paradigm. Referable to the expertise development which permits merging countless engineering procedures for the output of a modified portion that employed intricate configurations, CE expertise has got cumulative responsiveness. As such, this article intends to furnish a comprehensive appraisal of chemical fabrication progressions for steel substance evolution utilised in different applications. The inspection encompasses the current advancement of CE know-hows, a detailed taxonomy and classification of manufacturing operations. The focal point of the upcoming perspective of CE in substance investigation and application is further deliberated
Application of Biomass Pellets for Iron Ore Sintering
Authors: Kieush Lina , Koveria Andrii , Zhu Zuo Qiao , Boyko Maksym , Sova Artem , Yefimenko Vadym
Published: September 2021

The use of biomass as fuel might solve several technological and environmental issues and overcome certain challenges of sinter production. In particular, as revealed by comprehensive analyses, biomass can be used as fuel for iron ore sintering. In this study, we investigate the use of some raw and pyrolysis-processed biomass pellet types, namely wood, sunflower husks (SFH), and straw, for iron ore sintering. In the experiments, the pyrolysis temperature was set to 673, 873, 1073, and 1273 K, and the proportion of biomass in the fuel composition was set to 25%. It was established that the addition of biofuels to the sintering blend leads to an increase in the gas permeability of the sintered layer. The analysis of the complex characteristics of the sintering process and the sinter strength showed the high potential of wood and sunflower husk pellets pyrolyzed at 1073 and 873 K, respectively, for iron ore sintering. The analysis of the macrostructure of the sinter samples obtained using biomaterials revealed that with higher pyrolysis temperatures; the materials tend to have greater sizes and higher amounts of pores and cracks. The composition analyses of the resultant sinters revealed that with higher temperature, the FeO content of the sinters tends to increase.
Gasification of Waste Tyres: Thermodynamic Attainable Region Approach
Authors: Mavukwana Athi Enkosi , Sempuga Celestin
Published: September 2021

The innovative G-H graphical technique, a plot of Enthalpy vs Gibbs free energy was utilized to obtain a thermodynamically attainable region (AR) for the gasification of waste tyres. The AR is used to examine the interaction between the competing reactions in a gasifier and used to identify optimal targets for the conversion of waste tyres. The objective is to investigate the effect of temperature on the product selectivity. a temperature range of 25-1500°C at 1 bar was used for the analysis. The results show that at temperatures from 200°C to 600°C methane and carbon dioxide are dominant products at minimum Gibbs free energy. However, as the temperature increases, methane production decreases and hydrogen production become more favourable. Between 600°C and 700°C, carbon dioxide and hydrogen are dominant products. The AR results show that the products of gasification (CO and H2) are preferred products at minimum Gibbs free energy only at temperatures from 800°C to 1500°C, when both water and oxygen are used as oxidants. Therefore, syngas production from tyres is only feasible at high temperatures. Temperatures above 1000°C are recommended to prevent the formation of intermediate radicals.
Mathematical Models for Forecasting of 10Mn2VNb Steel Heavy Plates Mechanical Properties
Authors: Prysiazhnyi Andrii H. , Kukhar Volodymyr V. , Hornostai Vadym , Kudinova Ekaterina , Korenko Maryna , Anishchenko Oleksandr S.
Published: September 2021

The problem urgency for determining the optimal rolling and heat treatment schedules for providing the required indices of heavy plates physical and mechanical properties is shown. The use of statistical mathematical models for solving this problem is substantiated and the methodology for their design is described. Statistical mathematical models were designed using the mathematical statistics methods and Data Mining tools to determine the yield strength, ultimate tensile strength and percent elongation for 10Mn2VNb steel plates rolled under 3600 heavy plate mill conditions. Software for the numerical implementation of these statistical mathematical models has been developed. Applied software has been developed for the numerical implementation of the statistical mathematical models for predicting the heavy plate’s mechanical properties, and high calculation accuracy has been confirmed with the ones help: 95.82% for the yield strength, 96.78% for the ultimate tensile strength, and 91.48% for the percent elongation. The regularities of the influence for finish rolling factual temperature in the finishing stand of 3600 heavy plate mill and the plate thickness on 10Mn2VNb pipe steel physical and mechanical properties were identified by processing the database and using the designed software.
Foundations for a Practical Approach to Considering Sea-Level Rise in Coastal Projects
Authors: Collini Renee C. , Smallegan Stephanie M.
Published: September 2021

Abstract Sea-level rise (SLR) is a hazard multiplier already impacting coastal communities and ecosystems across all sectors including transportation, utilities, health, community planning, emergency management, and natural resource management. Fortunately, our ability to
understand future conditions and how they may exacerbate hazards has been rapidly increasing. Unfortunately, this rapid advancement in the science has led to gaps among the generation, access, and application of information for coastal decision making. Coastal professionals including engineers,
environmental consultants, floodplain managers, and natural resource stewards are often challenged when it comes to integrating SLR into planning and project design. The professional community lacks transparent, repeatable, science-based approaches that utilize existing tools for determining
how much SLR to consider while also specifically integrating the community's values. Further, related data and data products such as where to find locally relevant projections of future conditions and impacts remain woefully underutilized. This paper reviews how to access locally relevant
SLR projections, a risk-based framework for how to narrow down the available projections to a planning range, and how that information can be translated into relevant information about future conditions. Examples from projects in Jackson County, MS, and Dauphin Island, AL, are used to demonstrate
how relative SLR can be integrated into projects across timelines while considering adaptability and scale. Finally, key limitations, such as aging information and complexities of risk tolerance, are described.
COVID-19 and Blood Groups: A Six-Months Observational Study in Ferrara, Italy
Authors: Greco Salvatore , Fabbri Nicolò , Bella Alessandro , Bonsi Beatrice , Violi Alessandra , Fortunato Valeria , Govoni Maurizio , Graldi Giuseppe , Passaro Angelina
Published: September 2021

The current literature still gives a little information about the relationships between the ABO blood group system and the immune response to the virus or the different disease outcomes. Hypothesizing the presence of a predisposition by some blood groups to COVID-19, we searched for differences between patients towards the different outcomes of disease.We enrolled 330 inpatients with a diagnosis of COVID-19, determining both their ABO blood group system and Rh factor, collecting demographic, clinical and laboratory data. We searched for relationships with COVID-19 outcomes within an observation period of 180 days (Intensification of Care-IoC, Inhospital death, 180-days mortality). The most frequent ABO blood group was A (45.8%); a minor part was represented by group O (38.8%), B (11.5%), AB (3.9%). As for the Rh factor, 86.7% of patients were Rh-positive. There were no significant differences between blood groups and Rh factors as for age, length of hospital stays (LoS), or Charlson Comorbidity Index (CCI), nor we found significant relationships between the ABO groups and COVID-19 outcomes. A significant relation was found between AB group and IoC (p = 0.03) while as for the Rh factor, the patients with Rh factor positive died with less frequency during the stay (p = 0.03). Cox regression analyses showed substantial differences in the survival functions concerning the Rh factors. The Rh factor seems to be involved in the 180-day prognosis. The survival functions of patients with Rh factor positive show, in fact, significantly better curves when compared to those with Rh factor negative.
Experimental investigation of early assessment of corpora cavernosa fibrosis with two-dimensional shear wave elastography
Authors: Yu Li , Rao Wan-Ting , Tang Jing-Dong , Xing Jin-Fang
Published: September 2021

This study explored the usefulness of two-dimensional shear wave elastography (2D-SWE) in the early assessment of corpora cavernosa fibrosis (CCF). New Zealand male rabbits were randomly assigned to an experimental group or a control group. Recombinant human transforming growth factor beta 1 (TGF-β1) was injected into the dorsal penis tissue of rabbits in the experimental group. Conventional ultrasound and 2D-SWE examinations were performed before and 20 days after injection. Penile histological analysis was performed by hematoxylin–eosin staining, sirius red staining, and immunohistochemistry. Measurement of 2D-SWE examination results was performed using shear wave elastography quantitative measurement (SWQ). Histological analysis outcomes were the proportion of smooth muscle cells (SMCs), collagen fibers (CFs), collagen type I (Col I), and collagen type III (Col III), as well as the SMCs/CFs ratio, measured by sirius red staining. Other histological analysis outcomes were the positive area proportion (PAP) of TGF-β1 (PAPT), fibronectin (PAPF), and Col III (PAPC), measured by immunohistochemistry. After recombinant human TGF-β1 injection, SWQ was higher in the experimental group than that in the control group (P < 0.001); however, there were no differences in conventional ultrasound results. There were significant differences in histological outcomes between the two groups (all P < 0.05). These results indicated that 2D-SWE was superior for identifying early histological changes in CCF.
Contrasting Role of Autophagy in Different Types of Cancer
Authors: Chakraborty Pallab
Published: September 2021

Autophagy, the major cellular pathway, is known not only for the degradation and recovering in mammalian cells but also it maintains the cellular energy homeostasis and produces the building blocks. However, if the process starts destroying the essential ones other than the bad proteins, then the normal cellular control will be lost, and here, we see similar kinds of phenomena in cancer. It has been reported by previous papers related to this field that the novel pathway has paradoxical role in cancer, as it acts as both tumor promoter and suppressor. Therefore, autophagy could provide new resources for the improvement of antitumor drugs in near future. Here, in this review, we will know about the autophagy process in brief. We will also try to understand the contrasting role of autophagy in different cancers types, its significance as prognostic markers and its therapeutic implication for cancer treatment in the near future.
Microbiological Profile, Antibiogram, and Risk Factors of Patients with Diabetic Foot Infections
Authors: Kadhim Fatima H. , Mohammed Suhad Hadi
Published: September 2021

Background:

Diabetic foot ulcer (DFU) is considered a major social and economic problem, and it is also known as a leading cause of morbidity and mortality. Patients with DFUs frequently require amputation of the lower limbs, and in more than half of the cases, infection is the predominant factor. The aim of this systemic review is to highlight the risk factors such as age and gender associated with DFU infections, whether the infection is caused by single bacteria or polymicrobial infection and what is the most prevalent bacteria and their susceptibility pattern to currently used antibiotics.

Methods:

Three databases were searched from December 2020 to February 2021 including PubMed, Hinari, and Google Scholar. A total of 12 articles were included in the current meta-analysis.

Results:

Higher frequency of DFU in males than in females and maximum number of DFU mostly occur within the age group 40–60 years was reported. Monomicrobial infections in DFU were higher than monomicrobial infection. Escherichia coli, Pseudomonas, and Staphylococcus aureus were the most prominent microorganism. The higher grades of the DFUs were infected with more than one organism. High resistance rates of the isolated bacteria to the most commonly used antibiotics were documented and there were alarming growing resistance rate to Carbapenems which were considered the most effective Antibiotics nowadays.

Conclusions:

DFU infections are one of the major social and economic problems. There is an urgent need for continuous antibiotic sensitivity testing for the isolated bacteria to choose the appropriate antibiotics during the management and limit the spreading of multidrug-resistant bacteria and reduce the burden of health-care cost.
A Review on Biomarkers in Clinical Osteoporosis - Significance of Hydroxyproline
Authors: Adugani Soumya , Bannimath Gurupadayya , Sastry Purushothama
Published: September 2021

Osteoporosis is a chronic disorder in both men and women, where it decreases the bone quality and quantity, which may lead to a fall in bone mass density. It mostly occurs because of reduced peak bone mass or excessive formation or resorption during bone remodeling. Various degradation products of bone collagen are pyridinoline (Pyr), deoxypyridinoline, N-terminal telopeptides, and hydroxyproline (Hyp), which are excreted in the urine. Among that, Hyp is a crucial biomarker used to correlate osteoporosis condition. An overview of all the biomarkers and the signed note of Hyp with different analytical methods are provided in the current piece of work. To quantify amounts in biological samples, various methods have been developed for Hyp analysis, such as the colorimetric technique, gas chromatography, gas chromatography-mass spectrometry, and widely used high-performance liquid chromatography tests to detect the concentration of Hyp in different matrices. This review states the importance of biomarkers and Hyp's significance for detecting osteoporosis, clinical manifestation, and different analytical methods for Hyp. The study indicates that hydroxyproline is a unique biomarker used to detect osteoporosis. It is also showing the clinical manifestation of osteoporosis and discussed different analytical methods for hydroxyproline.
Ionotropic Glutamate Receptors and Their Implications in Cancer and Cancer Therapeutics
Authors: Goyal Shree , Chakraborty Pallab , Shankar Balasubramaniam
Published: September 2021

Glutamine, an excitatory neurotransmitter, is necessary for physiological as well as pathological processes. Other than neuronal disorders and/or cancers, glutamate receptors have also been associated with an array of other malignancies. The metabotropic glutamate receptor (mGluR 1–8 [like Groups I, II, and III]) and ionotropic glutamate receptor (iGluR) have been targeted to treat cancers like carcinoma of the lung, breast, prostate, and oral cancer. iGluRs present on N-methyl-D-aspartate (NMDA) and non-NMDA receptors are multisubunit complexes. Since these subunits of NMDA receptors influence the mTOR signaling pathway significantly, their antagonists such as memantine, ifenprodil, or diclozipine are often used in cancer chemotherapy. Non-NMDA receptors such as α-amino 3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA) and kainate undergo glutamine to arginine site-specific RNA editing inflicting changes in cancer cell permeability. Thus, the employment of antagonists specific to these receptors would provide an effective anticancer therapeutic approach. Since AMPA receptors and kainate receptors have a crucial role in neural development and other cellular processes, their contribution in tumorigenesis has been mainly recognized in brain tumors although their role in further cancers cannot be ruled out. Delta or orphan receptors are primarily classified based on sequence homology. The effect and activity of antagonists for metabotropic and iGluRs have been pointed out due to their remedial contribution in various tumors. This review also highlights the relation of a range of subunits to cancer and anticancer agents as curatives for future applications and investigations.
The outcome of transanal endoscopic microsurgery and adjuvant radiotherapy in patients with high-risk T1 rectal cancer
Authors: Khoury Wisam , Dauod Mai , Khalefah Mohamed , Duek Simon D. , Issa Nidal
Published: September 2021

Introduction:

Transanal endoscopic microsurgery (TEM) is considered the technique of choice for adenoma and low-risk T1 rectal cancer. The adequacy of such treatment for high-risk T1 tumours, however, is still controversial. The aim of the study is to evaluate our results with local excision of high-risk T1 cancers.

Materials and Methods:

Demographic, clinical data pertaining to patients undergoing TEM for T1 rectal cancer between 1999 and 2015 was retrospectively collected. Long-term outcomes were assessed for the entire cohort. Patients were classified into two groups: favourable and high-risk cancer features.

Results:

Three hundred and fifty-five TEM procedures were recorded in the study period. Forty-three patients were included in the present study. There were 20 females and 23 males, the median age was 69 ± 9. The median tumour distance from the anal verge was 6 cm (range 1–13 cm). Post-operative histopathology showed well/moderately differentiated T1 adenocarcinoma in 30 patients and poorly differentiated in 13. The overall survival for patients with favourable and high-risk features groups were 93.5% and 77%, respectively, while the local recurrence (LR) was 3.5% and 23.1%, respectively. Nine patients with high-risk features received adjuvant radiotherapy; one (11.1%) of them experienced LR.

Conclusions:

Local excision by TEM augmented by adjuvant radiotherapy may be a feasible alternative for selected patients with high-risk T1 rectal cancer. The addition of radiotherapy seems to decrease the rates of LR.
Proper surgical extent for clinical Stage I right colon cancer
Authors: Kwak Han Deok , Chung Jun Seong , Ju Jae Kyun , Lee Soo Young , Kim Chang Hyun , Kim Hyeong Rok
Published: September 2021

Purpose:

Pre-operative evaluation identifying clinical-stage affects the decision regarding the extent of surgical resection in right colon cancer. This study was designed to predict a proper surgical resection through the prognosis of clinical Stage I right colon cancer.

Patients and Methods:

We included patients who were diagnosed with clinical and pathological Stage I right-sided colon cancer, including appendiceal, caecal, ascending, hepatic flexure and proximal transverse colon cancer, between August 2010 and December 2016 in two tertiary teaching hospitals. Patients who underwent open surgeries were excluded because laparoscopic surgery is the initial approach for colorectal cancer in our institutions.

Results:

Eighty patients with clinical Stage I and 104 patients with pathological Stage I were included in the study. The biopsy reports showed that the tumour size was larger in the clinical Stage I group than in the pathological Stage I group (3.4 vs. 2.3 cm, P < 0.001). Further, the clinical Stage I group had some pathological Stage III cases (positive lymph nodes, P = 0.023). The clinical Stage I group had a higher rate of distant metastases (P = 0.046) and a lower rate of overall (P = 0.031) and cancer-specific survival (P = 0.021) than the pathological Stage I group. Compared to pathological Stage II included in the period, some of the survival curves were located below the pathological Stage II, but there was no statistical difference.

Conclusion:

The study results show that even clinical Stage I cases, radical resection should be considered in accordance with T3 and T4 tumours.
Marketing Mix Strategies of Small and Medium Tourism enterprises in Masvingo Province, Zimbabwe
Authors: Matura Phanos , Mbaiwa Joseph , Mago Stephen
Published: September 2021

The study sought to identify the marketing mix strategies of small and medium tourism enterprises (SMTEs), focusing on lodges and hotels of Masvingo Province in Zimbabwe. The continued low business performance by SMTEs in Masvingo Province motivated the study. The marketing mix theory underpinned the study. The ten tourism marketing mix strategies, namely product, price, place, promotion, people, process, physical evidence, programming, packaging, and partnership were the strategy variables of the study. The study employed a quantitative research approach. An online structured questionnaire was used to collect data from all the 250 owners and managers of SMTEs. Statistical Package for Social Sciences (SPSS) version 26 was used for the analysis of data. The main study findings were that SMTEs in Masvingo Province use all the ten tourism marketing mix strategies, albeit with varying degrees of application. The three most used strategies were product, packaging, and price. The three least used strategies were people, programming, and partnership. The moderately used strategies were physical evidence, promotion, place, and process. The value of this study relates to the use of a ten tourism marketing mix framework by SMTEs. Implications are that study organisations may not reach full performance potential due to unequal use of the ten tourism marketing mix strategy elements.
ЗДЕ, У СВЕТОМУ ГРАДУ ЈЕРУСАЛИМУ
Authors: Цветковић Теофиловић Ирена
Published: September 2021

Ова књига темељи се на проучавањима, пре свега, језика Поклоњенија Часнаго Гроба Гаврила Тадића, рукописа који је на- стао у Јерусалиму 1662. године. Проучавања овог значајног дела српске путописне про- зе започела је Ања Јефтић (1980 - 2008), асистент Филозофског факултета Универзитета у Источном Сарајеву у оквиру свог ма- гистарског рада, после чије трагичне смрти, снимци рукописа, захваљујући породици Јефтић, доспевају до Матице српске у Новом Саду.
Caso Comparabien.com
Authors: Rojas Valdez Kelly , Nakama Hokamura Gabriela Keiko
Published: September 2021

Comparabien.com ofrece a los consumidores servicios gratuitos, para que el usuario pueda comparar precios relacionados a “tarjetas de créditos, cuentas de ahorro, CTS, créditos vehiculares, hipotecarios, tarifas de Internet, TV por cable, y celulares”. 4 Los productos más visitados son los depósitos a plazo, así como los préstamos personales, dentro de los 15 productos que ofrecen.6 Mensualmente se registran cerca de 18,000 a 20,000 comparaciones en depósitos a plazo y préstamos personales, respectivamente.6 Desde que se lanzó al mercado en Perú, año 2010, ha registrado más de 4 millones de comparaciones.6 En el 2015, han recibido cerca de 200 mil visitas y 150 mil consultas por cada mes.6

Cuando Alfredo inició Comparabien.com pensó que, a pesar que deseaba establecer un negocio propio, debía seguir trabajando en Unilever. Para él fue difícil mantener estos dos trabajos en paralelo y, a la par, sostener a su familia que iba consolidándose y creciendo.2 Los primeros meses prácticamente trabajaba en Unilever para pagar los sueldos del personal de Comparabien.com. Al inicio esta idea fue difícil de entender por su familia y sus amigos, pensaban que era “botar el dinero,” pero poco a poco cada vez se daban cuenta que todo esto era producto de un sueño que Alfredo tenía.2 Todo iba relativamente bien, pero a fines de setiembre 2015 Comparabien.com está a punto de quebrar. Alfredo Ramírez se pregunta qué debía hacer, qué pasos debía seguir, o cómo podría ser posible que esta empresa con cerca de cinco años en el mercado pueda mejorar.
La incidencia de la inversión pública en el sistema de salud del Ecuador período 2010 – 2019
Authors: Carpio Freire Carlos Raul , Pablo Joseph , Solano Bianca
Published: September 2021

La presente investigación analizó la inversión pública y su incidencia en el sistema de salud de la ciudad de Guayaquil, durante el período 2010 – 2019, para lo cual se abordan las principales bases teóricas ligadas a las variables de estudio: inversión pública y sistema de salud pública. Para la recolección de datos, se llevó a cabo un estudio descriptivo, de enfoque cuantitativo para analizar los resultados de los montos de inversión destinados al sector salud por parte del gobierno ecuatoriano, y determinar aspectos relevantes como: satisfacción del usuario, cobertura de la demanda y logros más importantes en todo el tiempo de análisis.
ẢNH HƯỞNG CỦA PHÂN TRÙN QUẾ VÀ PHÂN BÓN LÁ ĐẾN MỘT SỐ TÍNH CHẤT ĐẤT VÀ NĂNG SUẤT GIỐNG LÚA OM18 TẠI TỈNH AN GIANG
Authors:   Đại học An Giang - Đại học Quốc gia thành phố Hồ Chí Minh, Nguyễn Văn Chương
Published: September 2021

The study on the effect of earthworm manure and HI-BORON 7-14 foliar fertilizer on chemical properties of soil and yield of rice OM18 was conducted in the Winter-Spring and Summer-Autumn seasons 2019-2020. The field experiments included four treatments and four replications in Long Xuyen City, An Giang province. Each treatment was the area of 48 m2 (8 m x 6 m). Treatments of season 1 (Winter-Spring) included: The control treatment (NT1) only applied NPK (85 kg N - 45 kg P2O5 - 45 kg K2O); (NT2): Incorporation of NPK and Hi-Boron 7-14 foliar fertilizer; (NT3): Incorporation of NPK and earthworm manure Atiga (300 kg ha-1); (NT4): Incorporation of NPK, earthworm manure Atiga (300kg ha-1) and Hi-Boron 7-14 foliar fertilizer. Treatments of season 2 (Summer-Autumn) were carried on the former experiment 1. However, treatments did not apply earthworm manure Atiga and spray Hi-Boron 7-14 foliar fertilizer (only applied 85 kg N-45 kgP2O5-45kg K2O). The results showed that the application of NPK, earthworm manure Atiga (300 kg ha-1) and Hi-Boron 7-14 foliar fertilizer improved organic matter, total nitrogen, available phosphorous and available potassium in soil. On the other hand, the combined fertilization increased the yield of rice OM 18 (11,3%) compared to the control treatment (without applying earthworm manure Atiga and spray Hi-Boron 7-14 foliar fertilizer). In Winter-Spring, the yield of rice OM18 in applying earthworm manure Atiga and spray Hi-Boron 7-14 foliar fertilizer had higher than 14,9% compared with applying only NPK in the Summer-Autumn season in the same treatment. The soil properties were not much improved due to no additional application of earthworm manure Atiga and spraying foliar fertilizer.
YẾU TỐ ẢNH HƯỞNG ĐẾN HIỆU QUẢ HOẠT ĐỘNG CỦA CÁC HỢP TÁC XÃ NÔNG NGHIỆP Ở HUYỆN QUẢNG ĐIỀN, TỈNH THỪA THIÊN HUẾ
Authors:   Trường Đại học Nông Lâm, Đại học Huế, Nguyễn Trần Tiểu Phụng , Lê Thị Hoa Sen ,   Trường Đại học Nông Lâm, Đại học Huế
Published: September 2021

Nghiên cứu này nhằm tìm hiểu các yếu tố ảnh hưởng đến hiệu quả hoạt động của các hợp tác xã nông nghiệp (HTX). Thông tin nghiên cứu được thu thập từ phỏng vấn 75 thành viên các HTX, 2 thảo luận nhóm và phỏng vấn sâu các giám đốc HTX. Nghiên cứu sử dụng phương pháp Analytical Hierarchy Process (AHP) để phân tích các yếu tố ảnh hưởng đến hiệu quả hoạt động của các HTX được xếp theo thứ bậc. Nghiên cứu đã chỉ ra được 6 yếu tố chính: Chính sách, thị trường, điều kiện tự nhiên, kinh tế và đời sống xã hội, năng lực HTX, năng lực thành viên và 36 yếu tố phụ. Trong đó, chính sách là yếu tố có ảnh hưởng nhất, tiếp theo lần lượt là yếu tố tự nhiên, thị trường, năng lực HTX, kinh tế và đời sống xã hội, năng lực thành viên. Các giá trị điểm hiệu quả bình quân tập trung vào yếu tố chính sách và năng lực HTX. Năng lực thành viên, năng lực quản lý, sự tâm huyết của HTX chưa được đánh giá cao. Vì thế, kết quả chỉ ra yếu tố còn hạn chế trong quá trình hoạt động của HTX, từ đó đưa ra các giải pháp nâng cao hiệu quả hoạt động cho các HTX.
ẢNH HƯỞNG CỦA KHỬ TRÙNG BẰNG IODINE KHÍ DUNG ĐẾN LƯỢNG VI KHUẨN TỔNG SỐ TRONG KHÔNG KHÍ CHUỒNG NUÔI GÀ 4 VÀ 8 TUẦN TUỔI
Authors:   Trường Đại học Nông Lâm, Đại học Huế, Lê Trần Hoàn , Lê Văn Phước ,   Trường Đại học Nông Lâm, Đại học Huế
Published: September 2021

Nghiên cứu được tiến hành để kiểm tra hiệu quả của khí dung sát trùng iodine đến hệ vi sinh vật không khí trong chuồng nuôi gà. Thí nghiệm đã được tiến hành với 940 gà thuộc giống 3F vào 4 và 8 tuần tuổi, được phân bố vào 28 ô chuồng nuôi hở với mật độ nuôi là 7,5 con/m2. Các chỉ tiêu về nhiệt độ, độ ẩm và tổng số vi khuẩn hiếu khí được xác định trước và sau khi phun thuốc khử trùng Iodine tại các mốc thời gian 7, 11 và 15 giờ trong 3 ngày liên tục. Kết quả cho thấy, trước khi sử dụng thuốc khử trùng Iodine, các chỉ tiêu về nhiệt, ẩm và tổng số vi khuẩn hiếu khí trong không khí có biến động, số lượng vi khuẩn tăng từ sáng đến trưa và giảm về chiều theo chiều tăng của nhiệt độ và chiều giảm của độ ẩm. Số lượng vi khuẩn hiếu khí vào các thời điểm đo trên ở chuồng gà 8 tuần tuổi là cao hơn ở chuồng gà 4 tuần tuổi, nhưng vẫn ở mức thấp hơn giới hạn cho phép. Sau khi khử trùng không khí, số lượng vi khuẩn hiếu khí giảm đột ngột xuống còn 4,4% - 5,4% so với trước khi khử trùng (giảm 94,6 - 95,6 điểm phần trăm), sau đó tăng dần đến mức trước khi khử trùng, ở chuồng gà 4 tuần tuổi sau 124 giờ (5 ngày) còn ở chuồng gà 8 tuần tuổi sau 100 giờ (4 ngày).
Chemická zonálnosť Ti-andraditového granátu v Ca-skarne z oblasti Magnetový vrch pri Tisovci (Slovenská republika)
Authors: Ružička Peter , Myšľan Pavol , Števko Martin , Kurylo Sergii
Published: September 2021

Analyzed garnets from the Magnet hill area near Tisovec (Slovak Republic) are part of a Ca-skarn mineral association consisting of diopside, clinochlore and calcite. Compositionally they correspond to Ti-rich andradite (Adr50.9-73.7) with minor grossular (Grs3.8-44.5) and schorlomite (Sch0.5-41.5) components. Garnets contain up to 13 wt. % TiO2 and in all of them YFe3+>YTi ratio prevails. Both sector and oscillatory chemical zoning were observed, which is primarily caused by variable distribution of Ti contents within individual garnet crystals. The three principal zones were distinguished in BSE imaging. The brightest are Ti-enriched zones with Ti content ranging from 0.85 to 0.50 apfu. Titanium gradually decreases in transitional zone (0.17 - 0.40 apfu) and reaches the minimum values in the dark zones (0.01 - 0.13 apfu). In the Ti-enriched zones the content of Si4+ and Al3+ is decreased due to substitution of Ti4+ and Fe3+ and assumed hydrogarnet substitution (SiO4)4- ↔ (O4H4)4-.