bluuebunny/crossref_metadata_2025 huggingface dataset:
Role of Per3, a circadian clock gene, in embryonic development of mouse cerebral cortex
Authors: Noda Mariko , Iwamoto Ikuko , Tabata Hidenori , Yamagata Takanori , Ito Hidenori , Nagata Koh-ichi
Published: April 2019

Per3 is one of the primary components of circadian clock system. While circadian dysregulation is known to be involved in the pathogenesis of several neuropsychiatric diseases. It remains largely unknown whether they participate in embryonic brain development. Here, we examined the role of clock gene Per3 in the development of mouse cerebral cortex. In situ hybridization analysis revealed that Per3 is expressed in the developing mouse cortex. Acute knockdown of Per3 with in utero electroporation caused abnormal positioning of cortical neurons, which was rescued by RNAi-resistant Per3. Per3-deficient cells showed abnormal migration phenotypes, impaired axon extension and dendritic arbor formation. Taken together, Per3 was found to play a pivotal role in corticogenesis via regulation of excitatory neuron migration and synaptic network formation.
Telocytes constitute a widespread interstitial meshwork in the lamina propria and underlying striated muscle of human tongue
Authors: Rosa Irene , Taverna Cecilia , Novelli Luca , Marini Mirca , Ibba-Manneschi Lidia , Manetti Mirko
Published: April 2019

Telocytes have recently emerged as unique interstitial cells defined by their extremely long, thin and moniliform prolongations termed telopodes. Despite growing evidence that these cells consistently reside in the stromal compartment of various organs from human beings, studies dealing with telocytes in structures of the oral cavity are scarce. Hence, the present morphologic study was undertaken to explore for the first time the presence and specific localization of telocytes within tissues of the normal human tongue, a complex muscular organ whose main functions include taste, speech, and food manipulation in the oral cavity. Telocytes were initially identified by CD34 immunostaining and confirmed by CD34/PDGFRα double immunofluorescence and transmission electron microscopy. CD34+/PDGFRα+ telocytes were organized in interstitial meshworks either in the tongue lamina propria or in the underlying striated muscle. Lingual telocytes were immunonegative for CD31, c-kit and α-SMA. Telopodes were finely distributed throughout the stromal space and concentrated beneath the lingual epithelium and around CD31+ vessels, skeletal muscle bundles/fibers, and intramuscular nerves and ganglia. They also enveloped salivary gland units outside the α-SMA+ myoepithelial cells and delimited lymphoid aggregates. These findings establish telocytes as a previously overlooked interstitial cell population worth investigating further in the setting of human tongue pathophysiology.
Spin crossover and structural phase transition in homochiral and heterochiral Fe[(pybox)2]2+ complexes
Authors: Gao Wan-Qing , Meng Yin-Shan , Liu Chun-Hua , Pan Yao , Liu Tao , Zhu Yuan-Yuan
Published: April 2019

Spin crossover and structural phase transition were discovered in three pairs of homochiral and heterochiral [Fe(pybox)2]2+ diastereomers.
Localization of ligands within human carbonic anhydrase II using 19F pseudocontact shift analysis
Authors: Zimmermann Kaspar , Joss Daniel , Müntener Thomas , Nogueira Elisa S. , Schäfer Marc , Knörr Livia , Monnard Fabien W. , Häussinger Daniel
Published: April 2019

Unraveling the native structure of protein–ligand complexes in solution enables rational drug design.
Thermophoresis of gold nanorods from surface enhanced Raman scattering and real-time Rayleigh scattering in solution
Authors: Makihara Takuma , Demers Steven M. E. , Cole Louis E. D. , Zhang Aobo , Hafner Jason H.
Published: April 2019

Surface-enhanced Raman scattering (SERS) from gold and silver nanoparticles suspended in solution enables a more quantitative level of analysis relative to SERS from aggregated nanoparticles and roughened metal substrates.
Modulating bioactivities of primary ammonium-tagged antimicrobial aliphatic polycarbonates by varying length, sequence and hydrophobic side chain structure
Authors: Fukushima Kazuki , Kishi Kohei , Saito Keita , Takakuwa Kazuki , Hakozaki Shunta , Yano Shigekazu
Published: April 2019

A highly antimicrobial, biocompatible, and fast biodegradable polycarbonate has been developed by incorporating primary ammonium and monoether side chains.
Difluoromethane as a precursor to difluoromethyl borates
Authors: Geri Jacob B. , Aguilera Ellen Y. , Szymczak Nathaniel K.
Published: April 2019

Difluoromethane (CF2H2) is an ecologically-friendly refrigerant which holds promise as a source of CF2H−. This manuscript demonstrates a Lewis acid/base pair approach to deprotonate CF2H2and capture CF2H−as a strategy to enable subsequent difluoromethylation.
Piezo-phototronic effect-modulated carrier transport behavior in different regions of a Si/CdS heterojunction photodetector under a Vis–NIR waveband
Authors: Zhao Zhi-Hao , Dai Yejing
Published: April 2019

The p-Si/n-CdS heterojunction photodetector exhibits different carrier transport behaviors under different light illumination conditions at photo-generated carrier excitation regions.
Bipyridine-based iridium(iii) triplet emitters for organic light-emitting diodes (OLEDs): application and impact of phenyl substitution at the 5′-position of the N-coordinating pyridine ring
Authors: Zaen Rena , Kim Myeongbee , Park Ki-Min , Lee Kyung Hyung , Lee Jun Yeob , Kang Youngjin
Published: April 2019

Three blue phosphorescent homoleptic iridium(iii) complexes based on a bipyridine ligand were synthesized.
Five new 3D transition MOFs based on 1-(3,5-dicarboxylatobenzyl)-3,5-pyrazole dicarboxylic acid displaying unique luminescence sensing towards Fe3+ and magnetic properties
Authors: Liu Wei-Ni , Tong Wen-Quan , Ma Lu-Lu , Wang Yao , Wang Jiao-Min , Hou Lei , Wang Yao-Yu
Published: April 2019

Five new 3D MOFs were constructed which 1(Zn) exhibits high luminescence sensing for Fe3+ ions, and 5(Cu) displays antiferromagnetic exchange phenomenons.
Integrated extraction and catalytic upgrading of microalgae lipids in supercritical carbon dioxide
Authors: Zimmerer Julia , Pingen Dennis , Hess Sandra K. , Koengeter Tobias , Mecking Stefan
Published: April 2019

Chemical building blocks are obtained from microalgae biomassviaan integrated extraction/catalytic upgrading approach.
Chemo-enzymatic pathways toward pinene-based renewable materials
Authors: Stamm A. , Tengdelius M. , Schmidt B. , Engström J. , Syrén P. O. , Fogelström L. , Malmström E.
Published: April 2019

Chemo-enzymatic conversion of underutilized forest-waste products into multi-functional polymers.
Retraction: Non-matrix matched calibration of element contents in stainless steel by using nanosecond and femtosecond laser ablation inductively coupled plasma mass spectrometry
Authors: Meng Jiuling , Zhang Xiaocheng , Cao Jingrui , Zhao Yupeng , Lű Tao
Published: April 2019

Retraction of ‘Non-matrix matched calibration of element contents in stainless steel by using nanosecond and femtosecond laser ablation inductively coupled plasma mass spectrometry’ by Jiuling Meng et al., J. Anal. At. Spectrom., 2019, DOI: 10.1039/c8ja00443a.
High-throughput electrical position detection of single flowing particles/cells with non-spherical shape
Authors: Reale Riccardo , De Ninno Adele , Businaro Luca , Bisegna Paolo , Caselli Federica
Published: April 2019

A novel all-electrical approach for cross-sectional position detection of flowing particles and cells.
Pore shape-reflecting morphosynthesis of lithium niobium oxide via mixed chloride flux growth in the presence of mesoporous silica
Authors: Sohmiya Minoru , Umehara Shinya , Enomoto Shinpei , Ide Yusuke , Okada Tomohiko , Sugahara Yoshiyuki , Ogawa Makoto
Published: April 2019

“Chloride flux growth in the rigid nanospace of mesoporous silica” was employed to produce lithium niobium oxide anisotropic nanoparticles.
PEDOT/NiFe2O4 nanocomposites on biochar as a free-standing anode for high-performance and durable microbial fuel cells
Authors: Senthilkumar N. , Pannipara Mehboobali , Al-Sehemi Abdullah G. , Gnana kumar G.
Published: April 2019

The competitive and hopeful route is endowed to convert wastes into profitable products by generating green energy from wastewater using PEDOT/NiFe2O4 nanostructures on the biomass-derived electrode as anode in microbial fuel cells.
Alkyl substituted 4-pyrrolidinopyridinium salts encapsulated in the cavity of cucurbit[10]uril
Authors: Xu Weitao , Liu Ming , Escaño Mary Clare , Redshaw Carl , Bian Bing , Fan Ying , Tao Zhu , Xiao Xin
Published: April 2019

The interaction between cucuribit[10]uril (Q[10]) and a series of 4-pyrrolidinopyridinium salts bearing aliphatic substituents at the pyridinium nitrogen, namely 4-(C4H8N)C5H5NRBr, where R = Et (g1), n-butyl (g2), n-pentyl (g3), n-hexyl (g4), n-octyl (g5), n-dodecyl (g6), has been studied in aqueous solution by 1H NMR spectroscopy, electronic absorption spectroscopy and mass spectrometry.
A fluorescent conjugated polymer photocatalyst based on Knoevenagel polycondensation for hydrogen production
Authors: Cao Xinhua , Li Yiran , Liu Binqian , Gao Aiping , Cao Juntao , Yu Yongsheng , Hei Xiaohan
Published: April 2019

An organic polymer photocatalyst (p-P) for hydrogen production was designed and synthesized through Knoevenagel condensation with a high yield.
Direct C–S bond formation via C–O bond activation of phenols in a crossover Pd/Cu dual-metal catalysis system
Authors: Khakyzadeh Vahid , Rostami Abed , Veisi Hojat , Shirmardi Shaghasemi Behzad , Reimhult Erik , Luque Rafael , Xia Yuanzhi , Darvishi Sima
Published: April 2019

A highly effective synthesis of unsymmetrical aryl sulfides was introduced under a dual-metal (Pd/Cu) catalysis system with a high turn-over number.
Divergent synthesis of 5′,7′-difluorinated dihydroxanthene-hemicyanine fused near-infrared fluorophores
Authors: Zheng Shasha , Lingyue Gu , Ong Michelle Jui Hsien , Jacquemin Denis , Romieu Anthony , Richard Jean-Alexandre , Srinivasan Rajavel
Published: April 2019

A late-stage SNAr functionalization strategy for the preparation of polyfluorinated near-infrared materials.
Intrinsically stretchable conductors and interconnects for electronic applications
Authors: Zhang Quan , Liang Jiajie , Huang Yi , Chen Huiyu , Ma Rujun
Published: April 2019

Intrinsically stretchable conductors and interconnects with excellent performance made from different types of materials find various applications in stretchable electronics.
Biosorption of anionic and cationic dyes via raw and chitosan oligosaccharide-modified Huai Flos Chrysanthemum at different temperatures
Authors: Zhang Yanzhuo , Wan Huilin , Zhao Jing , Li Jun
Published: April 2019

Raw Huai Flos Chrysanthemum and modified HFC were used for the first time as a biosorbent to remove cationic dyes Malachite green and Crystal violet, and anionic dyes Sunset yellow, Lemon yellow, and Carmine, at different temperatures (5–50 °C).
The design and fabrication of a multilayered graded GNP/Ni/PMMA nanocomposite for enhanced EMI shielding behavior
Authors: Im Hye Ji , Oh Jae Young , Ryu Seongwoo , Hong Soon Hyung
Published: April 2019

Three layered graded compositions of GNP/Ni/PMMA nanocomposite shows higher shielding effectiveness compared to that of monolayer nanocomposite.
Magnetomotility of untethered helical soft robots
Authors: Park Jeong Eun , Jeon Jisoo , Cho Jae Han , Won Sukyoung , Jin Hyoung-Joon , Lee Kwang Hee , Wie Jeong Jae
Published: April 2019

Magnetically active helical soft robots were synthesized to achieve efficient tether-less manipulation of the magnetomotility in order to avoid the on-board weight penalty and the distance restrictions originating from connection lines.
Plasmonic hot charge carriers activated Ni centres of metal–organic frameworks for the oxygen evolution reaction
Authors: Hu Wen-Chao , Shi Yi , Zhou Yue , Wang Chao , Younis Muhammad Rizwan , Pang Jie , Wang Chen , Xia Xing-Hua
Published: April 2019

Plasmonic hot charge carriers facilitate OER performance of MOFs with activated Ni centers and better matched energy levels.
Maximization of sodium storage capacity of pure carbon material used in sodium-ion batteries
Authors: Kang Jun , Kim Dae-Yeong , Chae Seen-Ae , Saito Nagahiro , Choi Si-Young , Kim Kwang-Ho
Published: April 2019

Generally, carbon anode materials used in sodium-ion batteries do not exhibit good electrochemical performance because of low coulombic efficiency (CE).
An ultra-high ion selective hybrid proton exchange membrane incorporated with zwitterion-decorated graphene oxide for vanadium redox flow batteries
Authors: Zhang Yuxia , Wang Haixia , Liu Bo , Shi Jingli , Zhang Jun , Shi Haifeng
Published: April 2019

A good trade-off effect between proton conductivity and vanadium ion permeability contributing ultra-high ion selectivity is demonstrated for SPEEK/ZC-GO hybrid membranes influenced by zwitterionic ZC-GO nanofillers.
Zinc–nickel–cobalt ternary hydroxide nanoarrays for high-performance supercapacitors
Authors: Huang Zi-Hang , Sun Fang-Fang , Batmunkh Munkhbayar , Li Wen-Han , Li Hui , Sun Ying , Zhao Qin , Liu Xue , Ma Tian-Yi
Published: April 2019

Zn–Ni–Co ternary hydroxide nanoarrays with a controlled morphology are used as the cathode material for supercapacitors for the first time.
A dynamic-coupling-reaction-based autonomous self-healing hydrogel with ultra-high stretching and adhesion properties
Authors: Wang Yingying , Xu Qizhen , Chen Taijun , Li Mian , Feng Bo , Weng Jie , Duan Ke , Peng Wenzhen , Wang Jianxin
Published: April 2019

We synthesized a dynamic coupling-reaction based hydrogel that showed excellent mechanical and adhesion properties, super-high self-healing properties and good biocompatibility.
Strategy for achieving efficient electroluminescence with reduced efficiency roll-off: enhancement of hot excitons spin mixing and restriction of internal conversion by twisted structure regulation using an anthracene derivative
Authors: Yu Yue , Ma Lin , Feng Zhao , Liu Boao , Zhou Huixin , Qin Hanlin , Li Huan , Song Jiangluqi , Zhou Guijiang , Wu Zhaoxin
Published: April 2019

A hot exciton spin mixing enhancement is realized by twisted structure regulation.
A portable self-calibrating logic detector for gradient detection of formaldehyde based on luminescent metal organic frameworks
Authors: Zhang Yu , Yan Bing
Published: April 2019

A portable self-calibrating logic detector based on luminescent metal organic frameworks was developed to detect formaldehyde more intuitively in water in our daily life.
Abnormal diffusion behaviors of Cu atoms in van der Waals layered material MoS2
Authors: Zhang Cai-Xin , Li Qianze , Tang Li-Ming , Yang Kaike , Xiao Jin , Chen Ke-Qiu , Deng Hui-Xiong
Published: April 2019

We investigated the diffusion properties of metal atoms in van der Waals layered materials using first-principles calculations combined with group theory analysis. We found that the diffusion rate of Cu in bulk MoS2 is much faster than other investigated metal atoms, whereas the diffusion rate of Cu in monolayer MoS2 is the slowest one among investigated systems.
Exploitation of the Escherichia coli lac operon promoter for controlled recombinant protein production
Authors: Browning Douglas F. , Godfrey Rita E. , Richards Kirsty L. , Robinson Colin , Busby Stephen J.W.
Published: April 2019

The Escherichia coli lac operon promoter is widely used as a tool to control recombinant protein production in bacteria. Here, we give a brief review of how it functions, how it is regulated, and how, based on this knowledge, a suite of lac promoter derivatives has been developed to give a controlled expression that is suitable for diverse biotechnology applications.
Attention in Bilingual Children With Developmental Language Disorder
Authors: Ebert Kerry Danahy , Rak Diane , Slawny Caitlyn M. , Fogg Louis
Published: April 2019

Purpose

Attention and language are hypothesized to interact in bilingual children and in children with developmental language disorder (DLD). In children who are bilingual, attentional control may be enhanced by repeated experience regulating 2 languages. In children with DLD, subtle weaknesses in sustained attention may relate to impaired language processing. This study measured attentional control and sustained attention in monolingual and bilingual children with and without DLD in order to examine the potential influences of bilingualism and DLD, as well as their intersection, on attention.

Method

Monolingual English-only and bilingual Spanish–English children aged 6–8 years were categorized into participant groups based on eligibility testing and parent interviews. Parent interviews included standardized assessment of language environment and parent concern regarding language. Participants completed 2 nonlinguistic computerized assessments: a flanker task to measure attentional control and a continuous performance task to measure sustained attention.

Results

One hundred nine children met all eligibility criteria for inclusion in a participant group. Regression models predicting performance on the attention tasks were similar for both sustained attention and attentional control. For both tasks, DLD was a significant predictor, and bilingualism was not. Measuring bilingualism continuously using parent-reported exposure did not alter results.

Conclusions

This study found no evidence of a “bilingual cognitive advantage” on 2 types of attention among sequential Spanish–English bilingual children but also found a negative effect of DLD that was consistent across both types of attention and both bilingual and monolingual children. Results are consistent with the broader literature on subtle nonlinguistic deficits in children with DLD and suggest these deficits are minimally affected by diverse linguistic experience.
Assessing the Link Between Perception and Production in Cantonese Tone Acquisition
Authors: Mok Peggy Pik Ki , Fung Holly Sze Ho , Li Vivian Guo
Published: April 2019

Purpose

Previous studies showed early production precedes late perception in Cantonese tone acquisition, contrary to the general principle that perception precedes production in child language. How tone production and perception are linked in 1st language acquisition remains largely unknown. Our study revisited the acquisition of tone in Cantonese-speaking children, exploring the possible link between production and perception in 1st language acquisition.

Method

One hundred eleven Cantonese-speaking children aged between 2;0 and 6;0 (years;months) and 10 adolescent reference speakers participated in tone production and perception experiments. Production materials with 30 monosyllabic words were transcribed in filtered and unfiltered conditions by 2 native judges. Perception accuracy was based on a 2-alternative forced-choice task with pictures covering all possible tone pair contrasts.

Results

Children's accuracy of production and perception of all the 6 Cantonese tones was still not adultlike by age 6;0. Both production and perception accuracies matured with age. A weak positive link was found between the 2 accuracies. Mother's native language contributed to children's production accuracy.

Conclusions

Our findings show that production and perception abilities are associated in tone acquisition. Further study is needed to explore factors affecting production accuracy in children.

Supplemental Material

https://doi.org/10.23641/asha.7960826
Speech-Language Pathologists' Clinical Decision Making for Children With Specific Language Impairment
Authors: Selin Claire M. , Rice Mabel L. , Girolamo Teresa , Wang Chien J.
Published: April 2019

Purpose

The speech-language pathologist's (SLP's) role for the specific language impairment (SLI) population is to provide specialized intervention targeting underlying deficits. However, children with SLI are often underrepresented on caseloads despite a high prevalence of the disorder and known long-term impacts. This study explored how SLPs use research to inform clinical decision making for SLI under neutral workplace circumstances.

Method

A national web-based survey was distributed to SLPs (
n
= 563) to investigate assessment and intervention clinical decision making for individuals with SLI. Vignettes portrayed various clinical profiles of SLI across dimensions of affectedness (child characteristics). Respondents made clinical decisions under neutral workplace conditions to remove confounds of work setting, policies, and caseload/time management constraints. The influence of child and practitioner characteristics on clinical decision making was explored.

Results

Variation across the vignettes emerged for the clinical decisions of SLP service recommendation, service delivery, intervention contents, specific treatment goals, and a monitoring approach. Practitioner characteristics had little influence, while child characteristics influenced responses across the clinical decision-making process. Assessment standard scores and percentiles were most strongly associated with SLP service recommendation.

Conclusion

The use of vignette methodology was demonstrated for the discipline of communication sciences and disorders. SLPs recommended services for individuals with SLI at higher rates than in actual practice; however, variation across the clinical decision-making process occurred. Implications include the reduction and removal of constraining workplace characteristics and increasing SLP competency for identifying the diagnostic profile of SLI.
Repeated sorting on the sliding window for OS‐CFAR
Authors: Didi Joseph Haim , Levanon Nadav
Published: April 2019

An algorithm is suggested for repeated sorting of a sliding window of n consecutive reference cells, required in order statistics‐constant false alarm rate radar detection. The sliding window surrounds a central cell under test with guard cells on its sides, which are excluded from the sorted reference cells. The algorithm's computational complexity is smaller by a factor of n/4 compared with performing a new independent sorting after each slide. That factor does not depend on the number of guard cells. The advantage of the new algorithm was confirmed by theoretical and numerical comparison with respect to two other recently reported approaches.
Analysis of the off-corner subsurface cracks of continuous casting blooms under the influence of soft reduction and controllable approaches by a chamfer technology
Authors: Zong Nanfu , Zhang Hui , Liu Yang , Lu Zhifang
Published: April 2019

In the current study, the morphology of the off-corner subsurface cracks located on the cross section of continuous casting bloom under a soft reduction operation was observed. A 3D thermo-mechanical model was adopted to calculate the temperature history, bulging deformation and stress distributions in the reduction region, and then to analyze the formation of the off-corner subsurface cracks under the influence of soft reduction. The results showed that the off-corner subsurface cracks can be formed under the influence of the extensive stress fields which develop in the cracking temperature range, especially located on the loosed side of the bloom corner region. Adjusting the chamfer angle and chamfer length can decrease stress concentration and bulging deformation to minimize the risk of off-corner subsurface cracks during the soft reduction operation.
Ceramides metabolism and impaired epidermal barrier in cutaneous diseases and skin aging: focus on the role of the enzyme PNPLA1 in the synthesis of ω-O-acylceramides and its pathophysiological involvement in some forms of congenital ichthyoses
Authors: Jonca Nathalie
Published: April 2019

The outermost layer of the skin, the stratum corneum, is essential for the protective barrier functions of the skin. It results from the stacking of corneocytes, the dead flattened cells resulting from epidermal terminal differentiation of underlying living keratinocytes. The cornified lipid envelope, encapsulating corneocytes, and the extracellular mortar-like multilayered lipid matrix, called lamellae, are two crucial elements of the epidermal barrier. Stratum corneum extracellular lipids are mainly composed of ceramides, cholesterol and free fatty acids. Ceramides, and more specifically the epidermis specific ω-O-acylceramides, are essential for lipid-matrix organization into lamellae and formation of the corneocyte lipid envelope. Pathophysiological studies of inherited lipid metabolism disorders recently contributed to a better understanding of stratum corneum lipid metabolism. In the lab, our data from patients with Autosomal Recessive Congenital Ichthyosis and a murine knock-out model showed that the enzyme PNPLA1 is essential for the last step of synthesis of omega-O-acylceramides. Skin aging is a complex biological process caused by genetic and extrinsic factors e.g. sun exposure, smoke, and pollution. Aging skin is marked by a senescence-related decline in lipid and water content, which ultimately impairs epidermal barrier function. Thus, aged epidermis is prone to develop altered drug permeability, increased susceptibility to irritants contact dermatitis and severe xerosis. Ceramide deficiency may account, at least in part, for the dysfunction of the stratum corneum associated with ageing. Hence, treatments able to increase skin-ceramide levels could improve the epidermal barrier function in aged skin. Many animal testing and clinical trials are taken in that regard.
Insulintherapie des Typ-2-Diabetes
Authors: Goelz Stefan , Wiesner Tobias
Published: April 2019

Diabetes mellitus ist eine Erkrankung mit einer zunehmenden Zahl von Betroffenen, in Deutschland und weltweit. Moderne Therapieoptionen mit zum Teil äußerst günstigen Auswirkungen auf den Eintritt kardiovaskulärer Ereignisse einschließlich der kardiovaskulären Mortalität machen Hoffnung auf eine weitere positive Beeinflussung durch konsequenteren Einsatz dieser Präparate. Insulin hat neben einer sehr geringen Rate an Kontraindikationen den Vorteil der guten Steuerbarkeit, belastet aber durch ein prinzipielles Risiko für Hypoglykämien. Im Folgenden wird der mögliche Einsatz anhand aktueller Daten dargelegt und interpretiert.
Wie ist die Wirksamkeit der apparativen Kompression bei
Beinen mit Ödem unter Anwendung von schenkellangen und wadenlangen Stiefeln im
Vergleich?
Authors: Mendoza Erika , Amsler Felix
Published: April 2019

Einleitung Zur apparativen intermittierenden Kompression bei Ödemen aller
Art sind hierzulande nur schenkellange Geräte, bzw. Hosen üblich. Wadenlange
Geräte sind auf dem Markt, aber noch nicht auf ihre Wirksamkeit untersucht. Die
Studie vergleicht die Wirksamkeit schenkellanger vs. knielanger
Entstauungsstiefel auf Volumenreduktion und Symptome.

Methode Es handelt sich um eine forscher-initiierte, monozentrische,
randomisierte Studie mit dem Vergleich der Wirksamkeit anhand Umfangmessungen
der Waden (händisch und maschinell), sowie Volumenmessungen (BT 600, Bauerfeind)
und Schmerz-Scores. Patienten mit Lipödem, Phlebödem, Lymphödem,
Adipositas-bedingtem Ödem und medikamentös/internistischem symmetrischem Ödem
wurden aufgenommen, vor der Behandlung im Stehen (nach Hinstellen, sowie nach 5
Minuten) vermessen und befragt (NRS 0–10), 30 Minuten an einem Bein (Seite
randomisiert) mit langem Stiefel (Lymphamat Gradient 300, Bösl), an einer Seite
mit kurzem Stiefel (Venenwalker Basic) behandelt und danach erneut vermessen und
befragt.

Ergebnisse Es wurden 41 Probanden aufgenommen, davon 4 Männer, 37 Frauen,
mittleres Alter 47,1 Jahre BMI 30,12 kg/m2 (± 5,42), 21 Beine „Links
lang“, 20 Beine „Rechts lang“, die meisten Teilnehmer hatten ein Lipödem
(26/41). Am Unterschenkel zeigten sich signifikante Verbesserungen der
Umfangmaße und Volumina unabhängig von der Wahl des Stiefels, zwischen beiden
Geräten waren die Unterschiede nicht signifikant. Die Wadenvolumina nahmen im
Stehen zu und wurden durch die Entstauung verringert. Wir fanden eine
signifikante Verringerung der Beschwerden im Stehen um 1,31 Punkte bei
schenkellangem Stiefel und um 1,27 Punkte bei wadenlangem Stiefel durch die
Entstauung (p < 0,001) ohne Differenz zwischen beiden Systemen. Es zeigte
sich eine Tendenz, dass die Auffüllung des Wadenvolumens und das Verstärken der
Beschwerden im Stehen nach der Entstauung langsamer geschieht.

Diskussion Üblicherweise liegen die meisten Beschwerden bei Ödemen (und
auch die Komplikationen) in den Waden vor. Der wadenlange Entstauungsstiefel ist
dem schenkellangen Stiefel bei der Volumen- und Beschwerdeverringerung nicht
unterlegen. Möglicherweise sind bei vielen Indikationen wadenlange
Entstauungsstiefel ausreichend.
Varikosis – Diagnostik und konservative
Therapie
Authors: Flessenkämper Ingo , Wienert Volker
Published: April 2019

Die große Bedeutung degenerativer Erkrankungen des epifaszialen Venensystems
liegt in der Beeinträchtigung des Alltagslebens so vieler Menschen, dass man sie
berechtigt als Volkskrankheit bezeichnen darf. In diesem Artikel sollen zunächst
der Standard in der Diagnostik und die konservative Therapie klinischpraktisch
beschrieben werden, während sich ein 2. Teil dann den invasiven Therapiemethoden
widmen wird.
Befundung und archivierung medizinischer Bilder: Quo vadis PACS?
Authors: Lang Michael
Published: April 2019

Mit der Digitalisierung der Medizingeräte steigt auch außerhalb der Radiologie der Bedarf an Bildmanagement- und Archivierungssystemen. Für klinikweite Lösungen mit einem zentralen Archiv gibt es unterschiedliche Ansätze.
Diagnosekodierung: Das Kind nicht mit dem Bade ausschütten
Authors: Spitzer Stefan G.
Published: April 2019

Seit im Jahr 2016 das Thema „Verhinderung von Kodieranreizen in Kassenvereinbarungen über Diagnose-vergütungen“ bekannt gemacht wurde, wird versucht, das System der Verteilung von RSA-Mitteln manipulationsresistenter zu machen. Aber auch der TSVG-Änderungsantrag 6 der Regierungsfraktionen führt nicht zur richtigen Lösung.
Cathodic Reduction of Caffeine: Synthesis of an Amino-Functionalized Imidazole from a Biobased Reagent
Authors: Pandolfi Fabiana , Chiarotto Isabella , Mattiello Leonardo , Rocco Daniele , Feroci Marta
Published: April 2019

The electrochemical reduction of caffeine, never carried out previously, yielded in DMF–Et4NBF4 N-formyl-N,1-dimethyl-4-(methylamino)-1H-imidazole-5-carboxamide, a highly functionalized imidazole product derived from the opening of the uracil ring. This reactivity is different from that of the methylated salt of caffeine, the cathodic reduction of which leads to the opening of the imidazole ring. Moreover, the product obtained by cathodic reduction, formylated at the exocyclic amide nitrogen, is different from that formed by treatment in an aqueous solution of sodium hydroxide followed by formylation. The latter is formylated at the exocyclic amine nitrogen.
Electronic Effects on Chiral NHC–Transition-Metal Catalysis
Authors: Yong Xuefeng , Thurston Ryan , Ho Chun-Yu
Published: April 2019

Though the properties of N-heterocyclic carbenes (NHCs) are generally dominated by the very strong σ donating character, electronic activation has emerged as an effective method to cooperate with typical carbon-framework steric optimization for highly enantioselective chiral NHC–transition-metal catalysis in recent years. NHC electronic changes associated with structural variations are now better understood by quantitative analysis using various methods. Here we highlighted and correlated some interesting chiral induction improvement methods, which were brought by electronic and steric cooperation on chiral NHC–transition-metal catalysis.

1 Introduction

2 Hemilabile Sidechains on NHC Ligands

3 Electronic and Bond Angle Changes Brought by NHC Core Size Variations

4 Electronic Activators on the NHC Core

5 Conjugated Systems and Fused Ring Structures

6 Remote Electronic Activators on the N-Aryl Ring

7 Summary and Outlook
Visible-Light-Mediated Tandem Sulfonylation/Cyclization of Vinyl Azides with Sulfonyl Hydrazines for the Synthesis of 6-(Sulfonylmethyl)phenanthridines under Mild Conditions
Authors: Mao Liu-Liang , Quan Li-Xia , Zhu Xian-Hong , Ji Cong-Bin , Zhou An-Xi , Chen Fayun , Zheng Da-Gui
Published: April 2019

A visible-light-mediated tandem sulfonylation/cyclization of vinyl azides with sulfonyl hydrazines was developed that provides an efficient and simple strategy for the synthesis of valuable 6-(sulfonylmethyl)phenanthridines with a broad substrate scope and satisfactory yields under mild conditions.
Hydroaminoalkylation of Allenes
Authors: Bielefeld Jens , Mannhaupt Steffen , Schmidtmann Marc , Doye Sven
Published: April 2019

The first examples of early-transition-metal-catalyzed hydroaminoalkylation reactions of allenes are reported. Initial studies performed with secondary aminoallenes led to the identification of a suitable titanium catalyst and revealed that under the reaction conditions, the initially formed hydroaminoalkylation products undergo an unexpected titanium-catalyzed rearrangement to form the thermodynamically more stable allylamines. The assumption that this rearrangement involves a reactive allylic cation intermediate provides a simple explanation of the fact that no successful early-transition-metal-catalyzed hydroaminoalkylations of allenes have previously been reported. As a result of the generation of the corresponding cation, the titanium-catalyzed intermolecular hydroaminoalkylation of propa-1,2-diene unexpectedly gives an aminocyclopentane product formed by incorporation of two equivalents of propa-1,2-diene.
Synthesis of δ-Carbolines and the Alkaloid Quindoline through a Molybdenum-Catalyzed Cadogan Cyclization and their Photoluminescent Properties
Authors: Shuvalov Vladislav , Rupp Anna , Kuratova Anna , Fisyuk Alexander , Nefedov Andrey , Sagitullina Galina
Published: April 2019

Cadogan reductive cyclization of substituted 2-aryl-3-nitropyridines to give δ-carbolines was performed under MoO2Cl2(DMF)2 catalysis with triphenylphosphine as a ligand. A new approach for the synthesis of the alkaloid quindoline based on a Mo(VI)-catalyzed Cadogan reductive cyclization of 2-phenyl-3-nitro-5,6,7,8-tetrahydroquinoline followed by aromatization of the resulting 2,3,4,10-tetrahydro-1H-indolo[3,2-b]quinoline is proposed. Various о-nitroarylpyridines, obtained by reacting acylpyruvates and cyclic hydroxymethylene ketones with nitroacetophenone enamines, were used as starting compounds for the preparation of δ-carbolines. The synthesized δ-carbolines were found to act as phosphors; their photophysical properties were studied and a structure–property relationship was revealed.
Intramolecular Diels–Alder and [3+2] Cycloaddition Reactions in the One-Pot Synthesis of Epoxypyrrolo[3,4-g]indazoles
Authors: Alizadeh Abdolali , Amir Ashjaee Asalemi Kaveh , Halvagar Mohammadreza
Published: April 2019

A one-pot approach for the synthesis of epoxypyrrolo[3,4-g]indazoles is presented. The first step was initiated by a three-component reaction of an isocyanide, a dialkyl acetylenedicarboxylate, and 2-furancarboxylic acid, and led to 1,3-dioxoepoxyisoindole, followed by the addition of hydrazonoyl chloride through a [3+2]-cycloaddition reaction in the second step. The key step in the formation of final compound involves a bicyclization strategy through intramolecular Diels–Alder­ (IMDA) reaction.
Electronic Health Record Documentation Patterns of Recorded Primary Care Visits Focused on Complex Communication: A Qualitative Study
Authors: Prater Laura , Sanchez Anthony , Modan Gabriella , Burgess Jennifer , Frier Kim , Richards Nathan , Bose-Brill Seuli
Published: April 2019

Background In a time-constrained clinical environment, physicians cannot feasibly document all aspects of an office visit in the electronic health record (EHR). This is especially true for patients with multiple chronic conditions requiring complex clinical reasoning. It is unclear how physicians prioritize the documentation of health information in the EHR.

Objective The goal of this study is to examine documentation tradeoffs made by physicians when caring for complex patients by comparing the content of office visit conversations with resulting EHR documentation.

Methods We used grounded theory method of qualitative analysis to assess emergent themes in the transcripts of 10 office visits, and then compared the themes to documentation in the EHR. Differences between discussion and subsequent documentation of social and emotional health topics and each of the other key categories were compared using the Wilcoxon signed-rank test.

Results The categories that emerged included “chronic conditions,” “acute/new problems,” “disease prevention,” and “social and emotional health.” We found that when social and emotional topics were discussed in the office visit, it was documented in the medical record only 30.6% of the time. Chronic conditions, acute/new problems, and disease prevention were documented in the EHR between 87.5 and 91.7% of the time after discussion. The differences between discussion and documentation of social and emotional topics were significantly greater than the differences for chronic conditions, acute/new problems, and disease prevention (all p < 0.05).

Conclusion Social and emotional factors, while extremely relevant to health management, are less likely than medical concerns to be documented after discussion in an office visit. This lack of documentation may hinder interdisciplinary communication between teams informing individualized therapeutic decisions during acute care handoffs, such as outpatient to inpatient care.
Early Adopters of Patient-Generated Health Data Upload in an Electronic Patient Portal
Authors: Ancker Jessica , Mauer Elizabeth , Kalish Robin , Vest Joshua , Gossey J.
Published: April 2019

Background and Objective Patient-generated health data (PGHD) may help providers monitor patient status between clinical visits. Our objective was to describe our medical center's early experience with an electronic flowsheet allowing patients to upload self-monitored blood glucose to their provider's electronic health record (EHR).

Methods An academic multispecialty practice enabled the portal-linked PGHD tool in 2012. We conducted a retrospective observational study of adult ambulatory patients using this tool between 2012 and 2016, comparing clinical and demographic characteristics of data uploaders with those of a group of patients with diabetes diagnoses and patient portal accounts seen by the same health care providers.

Results Over four years, 16 providers chose to use the tool, and 53 adult patients used it to upload three or more blood glucose values within any 9-month period. Of these patients, 23 were pregnant women and 30 were nonpregnant adults with diabetes. Uploaders had more encounters and portal log-ins than comparison patients but did not differ in socioeconomic status. Among the chronic disease patients, uploaders' mean hemoglobin A1c and body mass index (BMI) both dropped significantly in the months after upload.

Conclusion Despite the potential value of PGHD in health care, the rate of adoption of a tool allowing patients to upload PGHD to their provider's EHR has been slow. Among chronic disease patients, PGHD upload was associated with improvements in blood glucose control and BMI, but it is possible that the changes were because of increased motivation or intensive changes in medical management.
Multivariate discrimination of heat shock proteins using a fiber optic Raman setup for in situ analysis of human perilymph
Authors: Höhl Martin , Zeilinger Carsten , Roth Bernhard , Meinhardt-Wollweber Merve , Morgner Uwe
Published: April 2019

Raman spectroscopy has proven to be an effective tool for molecular analysis in different applications. In clinical diagnostics, its application has enabled nondestructive investigation of biological tissues and liquids. The human perilymph, for example, is an inner ear liquid, essential for the hearing sensation. The composition of this liquid is correlated with pathophysiological parameters and was analyzed by extraction and mass spectrometry so far. In this work, we present a fiber optic probe setup for the Raman spectroscopic sampling of inner ear proteins in solution. Multivariate data analysis is applied for the discrimination of individual proteins (heat shock proteins) linked to a specific type of hearing impairment. This proof-of-principle is a first step toward a system for sensitive and continuous in vivo perilymph investigation in the future.
Detection of proline using a novel paper-based analytical device for on-site diagnosis of drought stress in plants
Authors: Choi Young-Soo , Lee Mi Rha , Kim Cheol Soo , Lee Kyeong-Hwan
Published: April 2019

We developed and characterized a paper-based microfluidic sensor for the on-site diagnosis of drought stress in plants. Proline was used as a biomarker for analyzing drought stress, which was extracted by a colorimetric method using the proline-ninhydrin reaction. Paper was used as the main sensor material for the on-site detection of proline as it is easily transportable and cost-effective. The paper-based sensor was fabricated using wax-printing and origami methods, and the sensor was precoated with ninhydrin to allow for easy and convenient on-site use. Furthermore, a sample-to-ninhydrin ratio of 1:2 was found to confer optimal sensitivity to the drought diagnosis sensor. The concentration of proline in a sample was quantified by red-green-blue analysis to determine the change in green color intensity levels in response to distinct proline concentrations, which were detected by the sensor. The limit of detection of proline using the devised sensor was 657 µM, and the green color intensity level decreased with increasing proline concentration. In addition, the sensor was validated in an experimental drought stress model with Arabidopsis and subjected to drought stress for 21 days, and the amount of proline detected was 10 mM. The devised paper-based microfluidic sensor highlights the possibility of the on-site evaluation of drought stress in plants with potential to be utilized in various agricultural areas in the future.
Microwave-assisted reversal of a single electron spin
Authors: Godfrin C. , Lumetti S. , Biard H. , Bonet E. , Klyatskaya S. , Ruben M. , Candini A. , Affronte M. , Wernsdorfer W. , Balestro F.
Published: April 2019

The dynamics of a quantum system in a dissipative environment presents a rich and still largely unexplored phenomenology that is relevant for the control of quantum devices. The simplest problem can be modeled as a two-level system—such as a spin—in contact with a thermal bath. Here, we present experiments in which we monitor the spin reversal in a TbPc2 single-molecule spin transistor, and we show that the application of microwave pulses can cause the spin to flip between its two lowest-lying states (|↑⟩ and |↓⟩) at a rate that increases with increasing duration and power of the pulses. This process is neither resonant nor coherent with the microwave pulses. Moreover, an asymmetry appears in the |↓⟩→|↑⟩ and |↑⟩→|↓⟩ transition probabilities, suggesting that the process occurs out of equilibrium. We explain the experimental results and provide an estimate of the local temperature increase induced by the microwave pulses by means of a model that takes into account the energy exchange between the single Tb3+ electron spin and the local environment.
Inferring the high-pressure strength of copper by measurement of longitudinal sound speed in a symmetric impact and release experiment
Authors: Edwards R. J. , Rothman S. D. , Vogler T. J. , Furnish M. D.
Published: April 2019

Plate-impact techniques are used to investigate the equation of state and constitutive relations of copper at high pressures. The parameters are inferred from the velocity history of the surface of a shocked and then released copper plate in contact with a window. The initial shock interacts with the window interface sending a release wave back into the copper, thus, delaying any subsequent shock or release waves traveling toward the window. A backwards-characteristics code is used to regenerate the in situ particle velocities and correct for the presence of the window material. Given these corrections, the Lagrangian sound speed, pressure, and volume (density) are found, and from the sound speed, the strength parameters of the copper are calculated. This investigation finds a shear modulus of ∼100 GPa and a yield strength of ∼1 GPa for copper, at impact pressures of ∼130 GPa. The inferred shear modulus is in excellent agreement with the work of Hayes et al. The yield estimates are in broad agreement with, but are distinct from, previous theoretical and experimental studies.
Separate spin evolution of electrostatic energy flow in a degenerate quantum plasma
Authors: Ayub M. , Iqbal Z. , Shah H. A. , Murtaza G.
Published: April 2019

We have discussed energy densities and energy flow speed in a spin polarized plasma when longitudinal waves [Spin electron acoustic wave (SEAW) and Langmuir wave] propagate through the plasma. Employing the separate spin evolution quantum hydrodynamic model, we have derived the expression for energy densities and energy flow speed. It is found that the spin polarization changes the profiles of various energy densities. Specifically, we find that the spin polarization broadens the profile of the electrostatic energy density retaining the same peak value. In the case of kinetic and quantum energy densities, the profiles become narrower with the decrease in the peak value for the former case and increase for the latter. On the other hand, in the case of Langmuir waves, the spin polarization effect is similar for electrostatic energy density but opposite to the peak values of kinetic and quantum energy densities. The corresponding profiles become narrower as in the case of SEAW. Furthermore, energy flow speed associated with the SEAW and Langmuir wave is reduced for higher values of spin polarization. It is also noted that the contribution of Bohm potential in the dispersion compensates the reduction of energy flow due to spin polarization. The results are graphically analyzed for the choice of solid state plasma parameters.
Observational evidence of the drift-mirror plasma instability in Earth's inner magnetosphere
Authors: Soto-Chavez A. R. , Lanzerotti L. J. , Manweiler J. W. , Gerrard A. , Cohen R. , Xia Z. , Chen L. , Kim H.
Published: April 2019

We report on evidence for the generation of an ultra-low frequency plasma wave by the drift-mirror plasma instability in the dynamic plasma environment of Earth's inner magnetosphere. The plasma measurements are obtained from the Radiation Belt Storm Probes Ion Composition Experiment onboard NASA's Van Allen Probes Satellites. We show that the measured wave-particle interactions are driven by the drift-mirror instability. Theoretical analysis of the data demonstrates that the drift-mirror mode plasma instability condition is well satisfied. We also demonstrate, for the first time, that the measured wave growth rate agrees well with the predicted linear theory growth rate. Hence, the in-situ space plasma observations and theoretical analysis demonstrate that local generation of ultra-low frequency and high amplitude plasma waves can occur in the high beta plasma conditions of Earth's inner magnetosphere.
Particle motion driven by non-uniform thermodynamic forces
Authors: Burelbach Jérôme
Published: April 2019

We present a complete reciprocal description of particle motion inside multi-component fluids that extends the conventional Onsager formulation of non-equilibrium transport to systems where the thermodynamic forces are non-uniform on the colloidal scale. Based on the dynamic length and time scale separation in suspensions, the particle flux is shown to be related to the volume-averaged coupling between the Stokes flow tensor and the thermodynamic force density acting on the fluid. The flux is then expressed in terms of thermodynamic quantities that can be computed from the interfacial properties and equation of state of the colloids. Our results correctly describe diffusion and sedimentation and suggest that force-free phoretic motion can occur even in the absence of interfacial interactions, provided that the thermodynamic gradients are non-uniform at the colloidal surface. In particular, we derive an explicit hydrodynamic form for the phoretic force resulting from these non-uniform gradients. The form is validated by the recovery of the Henry function for electrophoresis and the Ruckenstein term for thermophoresis.