bluuebunny/crossref_metadata_2025 huggingface dataset:
Chymotrypsin activity signals to intestinal epithelium by Protease-Activated Receptor-dependent mechanisms
Authors: Guignard Simon , Saifeddine Mahmoud , Mihara Koichiro , Motahhary Majid , Savignac Magali , Guiraud Laura , Sagnat David , sebbag mireille , Khou Sokchea , Rolland Corinne , Bournet Barbara , Buscail Louis , Buscail Etienne , Alric Laurent , Camare Caroline , Ambli Mouna , Vergnolle Nathalie , Hollenberg Morley , Deraison Celine , Bonnart Chrystelle
Published: June 2023

Background and purpose Chymotrypsin is a serine protease produced by the
pancreas and secreted into the lumen of the small intestine, where it
digests food proteins. Due to its presence in the gut lumen, we
hypothesized that chymotrypsin activity may be found close to epithelial
cells and signals to them via Protease-activated receptors (PARs). We
deciphered molecular pharmacology mechanisms for chymotrypsin signaling
in intestinal epithelial cells. Experimental approaches The presence and
activity of chymotrypsin were evaluated by western blot (WB) and
enzymatic activity tests in luminal and mucosal compartments of murine
and human gut samples. The ability of chymotrypsin to cleave the
extracellular domain of PAR1 or PAR2 was assessed using cell lines
expressing N-terminally-tagged receptors. The cleavage site of
chymotrypsin on PAR1 and PAR2 was determined by HPLC-MS analysis. To
study the pharmacology of chymotrypsin signals, we investigated calcium
signaling and ERK1/2 activation using calcium mobilization assays and WB
in CMT93 intestinal epithelial cells. Key results We found that
chymotrypsin was present and active in the vicinity of the murine and
human colonic epithelium. Molecular pharmacology studies evidenced that
chymotrypsin cleaved both PARs receptors. While chymotrypsin activated
calcium and ERK1/2 signaling pathways through PAR2, it disarmed PAR1,
preventing further activation by its canonical agonist thrombin.
CONCLUSION Our work suggests that the function of chymotrypsin in the
gut lumen goes well beyond a simple digestive role. Our results
highlight the ability of chymotrypsin to signal to intestinal epithelial
cells via PARs, which may have important physiological consequences in
gut homeostasis.
Frailty in clinical drug trials: application to recruitment, subgroup analyses and outcomes
Authors: Nguyen Tu , Ahmad Fahed , Lindley Richard
Published: June 2023

Clinical drug trials have traditionally focused on younger, healthier
participants with less comorbidities and excluded frail older adults due
to concerns regarding their ability to tolerate and respond to
treatments. However, with population ageing, drug trials are
increasingly turning their attention to older, frailer people. The aim
of this review is to provide an overview of how frailty was assessed in
published studies related to clinical pharmacological trials, and on the
interaction of frailty on the safety and efficacy of the treatments. We
searched MEDLINE, EMBASE and Cochrane for studies published in English
that focused on clinical drug trials in older people. The review showed
that frailty has been increasingly and successfully applied into
clinical drug trials, especially trials in patients with cardiovascular
disease and cancer. In most of the studies in the review, frailty was
assessed retrospectively. How frailty was treated in statistical
regression models was not consistent among the studies. Frailty was
treated as an ordinal variable (with different levels of frailty) or
binary variable (frail/non-frail) using cut-offs in some studies, and as
a continuous in some other studies. There was heterogeneity in the
effect of frailty, depending on the disease and treatment type. The
results of this review suggest that frailty should not be assumed to
always attenuate treatment effects, and routine measurement of frailty
in participants in clinical drug trials would improve our knowledge of
the effect of treatment in the frail and identify those who have more or
least to gain from treatment.
Challenges in Bridging the Gap Between Protein Structure Prediction and Functional Interpretation
Authors: Varadi Mihaly , Tsenkov Maxim , Velankar Sameer
Published: June 2023

The rapid evolution of protein structure prediction tools has
significantly broadened access to protein structural data. Although
predicted structure models have the potential to accelerate and impact
fundamental and translational research significantly, it is essential to
note that they are not validated and cannot be considered the ground
truth. Thus, challenges persist, particularly in capturing protein
dynamics, predicting multi-chain structures, interpreting protein
function, and assessing model quality. Interdisciplinary collaborations
are crucial to overcoming these obstacles. Databases like the AlphaFold
Protein Structure Database, the ESM Metagenomic Atlas, and initiatives
like the 3D-Beacons Network provide FAIR access to these data, enabling
their interpretation and application across a broader scientific
community. Whilst substantial advancements have been made in protein
structure prediction, further progress is required to address the
remaining challenges. Developing training materials, nurturing
collaborations, and ensuring open data sharing will be paramount in this
pursuit. The continued evolution of these tools and methodologies will
deepen our understanding of protein function and accelerate disease
pathogenesis and drug development discoveries.
Analysis of solar radiation repercussions on 3-D Darcy- Forchheimer nanofluid in Flat Plate Solar Collector(FPSC) with power-law Stretching
Authors: P.A Dinesh , Yadav Sweeti , K Roopa , Prahaladaiah Diwakar
Published: June 2023

Research optimises in renewable energy areas like solar energy to
overcome the universal energy crisis. FPSC are extensively used for the
collection of low-temperature solar thermal energy. Research reveals
porous material is the most affordable and decisive technique in
improvising FPSC. A 3-D model depicts the problem more precisely. This
work uses nanofluid to numerically simulate the solar radiation effect
on the 3-D Darcy-Forchheimer model of FPSC. Nanofluid flow is considered
along the power law of a stretching surface inside the solar collector
with the impact of thermal source/sink, solar diffusion and magnetic
induction. Mathematical equations are reformulated according to flow
problems under different constraints. The resultant highly nonlinear
coupled homogeneous PDEs are explicated using MAPLE software.
Investigations are carried out on heat transfer characteristics using
various non-dimensional parameters. A comparative analysis of linear and
nonlinear stretching is done to analyse the problem more efficiently.
This research is obliging in increasing the efficiency of solar
collectors. Also, outcomes of this research can be used in many areas
like preheating fluids in industries, space heating, household solar
water system etc.
Pace and parity predict short-term persistence of small plant populations.
Authors: DePrenger-Levin Michelle , Wunder Michael
Published: June 2023

Life history traits are used to predict asymptotic extinction risk from
dynamic conditions. Less is known about how life history traits interact
with stochasticity and population structure of finite populations to
predict near-term extinction risk. Through empirically parameterized
matrix population models, we study the impact of life history
(reproduction, pace), stochasticity (environmental, demographic), and
population history (existing, novel) on the near-term population
dynamics of finite populations of plant species. Among fast and slow
pace and either uniform or increasing reproductive intensity or short or
long reproductive stage duration, slow, semelparous species are at the
greatest risk of extinction. Long reproductive stages buffer existing
populations from extinction while extinction risk of novel populations
decrease when reproductive effort is uniformly spread across the
reproductive stage. Our study highlights the importance of population
structure, pace, and two distinct aspects of parity for predicting
near-term extinction risk.
On Aristotle’s notion of abortion
Authors: Petrovic Marija
Published: June 2023

In Book VII of Politics, Aristotle discusses abortion as one of the means of
population control. Since the prosperity of a state depends, among other
factors, on finding the right balance between its size and the number of
inhabitants, Aristotle argues that abortion is permissible in cases where
the prescribed number of children is exceeded, but only ?before the onset of
sensation and life,? which means before it acquires a sensitive soul. A
detailed analysis of Aristotle?s understanding of human physiological
development shows that the fetus acquires a sensitive soul on the fortieth
or ninetieth day after conception, and this is taken as the limit beyond
which abortion is not permitted. Aristotle believed that the fetus does
originate as a human being, but gradually becomes one through development.
Considering the broader context in which Aristotle discusses abortion, we
can see that, despite the normative framework, these considerations cannot
be understood outside the place they have in his theory and cannot be
abstracted and applied directly to the contemporary bioethical debate on
abortion.
Antimicrobial Peptide Loss, Except for LL-37, is not Characteristic of Atopic Dermatitis
Authors: Szabó Lilla , Kapitány Anikó , Somogyi Orsolya , Alhafez Iman , Gáspár Krisztián , Palatka Réka , Soltész Lilla , Törőcsik Dániel , Hendrik Zoltán , Dajnoki Zsolt , Szegedi Andrea
Published: June 2023

Atopic dermatitis is an inflammatory skin disease characterized by significant permeability barrier damage. Regulation and maintenance of permeability and antimicrobial skin barriers are strongly connected. There is a lack of comprehensive studies of the expression of all 5 major antimicrobial peptide functional groups in atopic dermatitis. The aim of this study was to investigate the major antimicrobial peptide functional groups in lesional atopic dermatitis, non-lesional atopic dermatitis, and healthy control samples, using real-time quantitative PCR and immunohistochemistry. Lesional psoriatic skin was also examined as a diseased control. No differences in mRNA levels were detected between non-lesional atopic dermatitis and healthy control skin, and, at the protein level, the only change was the significantly decreased LL-37 in non-lesional atopic dermatitis. In lesional atopic dermatitis, several antimicrobial peptides were significantly altered at the mRNA level, while, at the protein level, all antimicrobial peptides were significantly upregulated or unchanged, except for LL-37, which decreased, compared with healthy controls. Antimicrobial peptides were similarly elevated in lesional atopic dermatitis and lesional psoriatic skin, with somewhat higher expression in lesional psoriatic skin, except for LL-37. In conclusion, LL-37 was the only antimicrobial peptide that was impaired in both non-lesional and lesional atopic dermatitis, highlighting its potential pathogenetic or exacerbating role in the initial stages of the disease.
A novel etiological classification in patients with intracranial large vessel occlusion and endovascular treatment: discordance with the classic and SSS TOAST systems: A retrospective cohort study
Authors: Kim Min , Lee Seong-Joon , Park So Young , Hong Ji Man , Lee Jin Soo
Published: June 2023

Purpose: Among patients with acute ischemic stroke (AIS), those with intracranial large vessel occlusion (LVO) should undertake endovascular treatment (EVT) based on mechanical thrombectomy. Although the Trial of Org 10172 in Acute Stroke Treatment (TOAST) classification system has been used in overall population of patients with AIS, especially for secondary prevention. In the current study, a new classification system for the LVO population is proposed.Methods: The classic TOAST and Stop Stroke Study TOAST (SSS TOAST) were applied to the LVO population. Based on discordance with those systems, a new LVO classification system was developed and applied to the LVO population. The new system comprised extracranial atherosclerosis (ECAS), intracranial atherosclerosis (ICAS), cardioembolism (CE), cryptogenic embolism, stroke of undetermined etiology (SUE; two or more etiologies), and stroke of other determined etiology (SOE) where small artery occlusion was removed.Results: The LVO classification system comprised 43 ECAS (6.52%), 141 ICAS (21.36%), 303 CE (45.91%), 75 cryptogenic embolism (11.36%), 75 SUE (11.36%; cardioembolic source in 98.67%), and 23 SOE (3.48%) patients. The ICAS group had a significantly longer median onset-to-puncture time than the other groups. In the ICAS group, 102 of 141 (72.34%) remained partial recanalization after EVT.Conclusion: The LVO classification system differentiating ECAS and ICAS in patients with large artery atherosclerosis and classifying cryptogenic embolism is more suitable for patients with EVT for intracranial LVO. Further studies for predicting underlying ICAS and planning treatment strategy should be performed.
The Implementation of Inclusive Education by English Teachers to Teach Slow Learners at SMK Negeri 3 Singaraja
Authors: Yekti Cintya Maha , Ratminingsih Ni Made , Dewi Kadek Sintya
Published: June 2023

Inclusive education has been increasing significantly in Singaraja and helping the students with special needs as well as getting their right to have a proper education. Since inclusive was a new policy in education, new research was needed to find out how the implementation and the obstacles faced in inclusive. This study was aimed at investigating the implementation of inclusive education by English teachers to teach slow learners included in a regular classroom. This research was conducted at SMK Negeri 3 Singaraja as one of the general schools which implemented inclusive education. This research was in the form of qualitative research with a case study method. The data were obtained through document study, interviews, and observations. The findings show that (1) the English teachers used same teachers' preparation and modified some activities in the learning process and used different assessment, and (2) there were also found supporting factors such as complete administration, a good way of transferring knowledge, used different assessment and also found challenging factors in implementing inclusive education such as lack of trained teacher, lack of inclusive policy, and lack of differentiation in instructions. Inclusive education has been implemented at SMK Negeri 3 Singaraja but still has to be improved.
Correlation between Perceptions of School Support and The Mastery Of Information Technology to Teachers' Self-Efficacy
Authors: Serriawati Missa , Azwar Saifuddin
Published: June 2023

Curriculum 2013 requires teachers to master information technology in order to teach in a better way. In fact, many elementary school teachers have not been able to use computers. Lack of school support and information technology skills may be associated with low self-efficacy. The purpose of this study is to determine whether teachers’ self-efficacy can be predicted by school support and mastery of information technology. Subjects of this research were 225 teachers from 19 elementary schools in Daerah Istimewa Yogyakarta province, which have become the pilot project of Curriculum 2013. Instruments used in this study were Self Efficacy Scale, School Support Scale, and Information Technology Test. The data were analyzed using multiple linear regression analysis. The result of this study found that school support and mastery of information mastery simultaneously positively correlated to teachers’ self-efficacy with a correlation value of 139,616    significance level p<0,01. The effective contribution of school support and mastery of information mastery together positively correlated to teachers’ self-efficacy is 55,7%.
Self adjustment dynamic in sojourner college students
Authors: Harahap Fadhilah Al Zahra
Published: June 2023

Studying in a university outside hometown is one of the common way for high school graduates to get access to a better quality of higher education. These new students settle down in new surroundings much different from their respective homes. They adapt to adjust to the new situation. This research aims to understand dynamics of self adjustment of the students during their study in Daerah Istimewa Yogyakarta (Special Province of Yogyakarta). The method used in the research was qualitative phenomenology. The writer found that there were five factors that play roles in the adjustment, which are: (1) support; (2) obstacle; (3) character; (4) intrapersonal; and (5) interpersonal.
The millennials: Adversity intelligence and work engagement
Authors: Prahara Sowanya Ardi , Dewi Ros Patriani , Astuti Kamsih
Published: June 2023

The industrial world is transforming towards the era of revolution 4.0 and society 5.0. In this era, digital technology is applied and becomes the center of human life. Demand that the millennial generation who currently dominates the job market in Indonesia have adversity intelligence so that they can be more engaged in their work and have a positive impact on company performance and development. This study aims to determine the relationship between adversity intelligence and work engagement in the millennial generation. Subjects in this study were 214 employees, aged 20-39 years who live in Yogyakarta and have worked at least one year. The data collection method in this study uses a Likert scale model. Data were collected using the Work Engagement Scale and the Adversity Intelligence Scale, by sending the scale via Google Form to respondents. The data analysis technique used is the product-moment correlation from Karl Pearson. Based on the data analysis, the correlation coefficient (R) was obtained for 0.820 (p <0.01). These results indicate that there is a very significant positive relationship between adversity intelligence and work engagement among millennial employees living in Yogyakarta. This study provides an overview of the level of work engagement and adversity intelligence for millennial generation employees, so as to increase the work engagement of millennial generation employees by increasing their adversity intelligence.
Attachment Style, Friendship Quality and the Mediating Effect of Communication Skills in Young Adults Friendship
Authors: LIM Ai Shin
Published: June 2023

Liberman and colleagues (1999) argue for the importance of investigating attachment relationships among peers, as they play a crucial role for individuals from adolescence into adulthood. Markiewicz, Doyle, and Brendgen (2001) demonstrated the important link between attachment style and friendship quality, noting that secure attachment predicted perceptions of friendship quality. This study looked specifically at the associations between attachment, communication and  the quality of relationship shared between friends using four different questionnaires; Attachment Style Questionnaire (ASQ) by Feeney, Noller & Hanrahan, (1994), Bartholomew and Horowitz’s (1991) Relationship Questionnaire, Communication Functions Questionnaire (CFQ) by Burleson & Samter (1990), and the Network of Relationship Inventory- revised  by Furman & Buhremester, (1992).
The Role of Adversity Quotient and Authoritative Parenting on Academic Achievement of College Students in Denpasar City
Authors: Astari Putri I Gusti Ayu Rantika , Swandi Ni Luh Indah Desira
Published: June 2023

This study aims to determine the role of adversity quotient and authoritative parenting on college students academic achievement. Subjects in this quantitative study were specifically college students in Denpasar, the biggest city in Bali which amounted to 106 people who were selected through a multi-stage cluster sampling technique. Instruments used were Adversity Quotient Scale, Authoritative Parenting Scale and students GPA. The results of multiple linear regression test showed a significance value of 0.000 (p <0.05) and an R value of 0.832 with a coefficient of determination (R Square) of 0.692, which means that Adversity Quotient and authoritative parenting style together play a role of 69, 2% towards academic achievement. The higher the level of Adversity Quotient and authoritative parenting, the higher the academic achievement of college students
Loose-part media and pictures on environmental themes increase interest in early childhood learning
Authors: Shalichah Siti , Santoso  , Widjanarko Muchammmad
Published: June 2023

Children experience difficulties in learning at school and a lack of interest in children during the learning process. Teachers and parents need to be made aware of this. They think this is because children are lazy when studying. This study analyzed loose part media and pictures on environmental themes to increase interest in early childhood learning. This research method uses quantitative methods with steps to formulate problems, determine the theoretical basis, formulate hypotheses, collect data, conduct data analysis, and draw conclusions. The analysis used in this research is quantitative and qualitative. Includes using loose part media and images, learning observations, and product validation of loose parts media and images. Analysis of loose part media and images to increase interest in early childhood learning includes six stages. The results showed a significant effect of the application of loose part media on environmental themes on children's learning interest based on a t count of 17,812 and a t table of 1.9977, so the t count is more than the t table. The application of environmental theme image media significantly affects children's learning interests with a t table of 1.9995. There is a significant influence of the application of environmental theme loose part media and environmental theme image media on children's learning interest with a t count of 14,483 and a t table of 1.9939. The conclusion is that there is a significant influence of the application of environmental theme loose part media and environmental theme image media on the learning interest of group B students.
Apoyos educativos para impulsar emprendimientos relevantes e innovadores: lecciones de las empresas latinoamericanas premiadas internacionalmente
Authors: Espinosa Espíndola Mónica Teresa
Published: June 2023

Los apoyos educativos preparan a los alumnos para trabajar o emprender. Esta investigación se realizó por la necesidad de reforzar la educación universitaria para promover emprendimientos por oportunidad durante el proceso de enseñanza-aprendizaje en una universidad mexicana, donde los alumnos tienen intención emprendedora, pero contemplan empresas tradicionales. El objetivo de la investigación fue identificar los apoyos educativos con posibilidades de integración en la universidad para el impulso de emprendimientos relevantes e innovadores, a partir de las lecciones extraídas del análisis de las empresas latinoamericanas incluidas entre las 100 Empresas Tecnológicas Innovadoras reconocidas por el Foro Económico Mundial (WEF por sus siglas en inglés) en 2022. El método de investigación fue cualitativo, transversal, exploratorio y descriptivo. El marco conceptual se basó en la Teoría del Comportamiento Planificado. Se aplicó una encuesta para conocer la intención emprendedora de los alumnos de la universidad sujeta de estudio y se analizaron las empresas latinoamericanas antes mencionadas para obtener lecciones. Resultados: Se encontró que el 85% de los alumnos quiere emprender, pero el 82% se siente inseguro de poder realizar actividades innovadoras, por lo que contempla únicamente emprendimientos por necesidad. En el análisis de las empresas latinoamericanas, se encontró que se fundaron con trabajo conjunto de personas con experiencia tanto laboral como empresarial. Sus objetivos se relacionan con problemáticas globales, utilizan tecnología, innovación y son rentables. A partir de tales lecciones, se identifican algunos apoyos educativos consistentes en el desarrollo de actividades co-curriculares para impulsar emprendimientos por oportunidad. Conclusiones: Los apoyos educativos propuestos pueden impulsar a los alumnos para que consideren emprendimientos con mayor relevancia e innovación.
evolução da e-audiologia no Brasil e no mundo
Authors: Paula Susana Vieira de , Vasconcelos Karla Anacleto de
Published: June 2023

Introdução: Os termos ‘e-audiologia’, ‘teleaudiologia’, ‘teleprática em audiologia’ e variações, possuem uma característica em comum: avanços tecnológicos na audiologia. Objetivo: O estudo busca avaliar a evolução e desdobramentos da audiologia em modelo remoto no Brasil em comparação a outros países, assim como as vantagens e adversidades proporcionadas por este modelo. Método: Uma revisão integrativa foi realizada por meio de busca e análise de publicações disponíveis nas bases de dados Taylor & Francis Online, PubMed, Scielo, Thieme, ASHAWire e Academia.edu, entre novembro de 2020 e fevereiro de 2021, nos idiomas português brasileiro e inglês. Os termos de busca foram: e-audiologia, e-audiology, teleaudiologia, teleaudiology, telessaúde em audiologia, telehealth in audiology, teleprática em audiologia, telepractice in audiology. Foram considerados artigos publicados de forma gratuita abordando a audiologia em modelo remoto, sem limites ao ano de publicação. Resultados: Foram encontrados 987 artigos, mas apenas 79 foram selecionados para análise na presente revisão. O número de publicações apresentou um aumento nos últimos 5 anos e o Brasil, em comparação a outros países, mostrou bom nível de desenvolvimento em pesquisas na área da teleaudiologia. Conclusão: Não há dúvidas de que a teleaudiologia já possui um impacto significativo e positivo como modelo de atuação audiológica e, assim como em toda evolução, a e-audiologia vem oferecendo, ainda, maiores oportunidades para seus usuários. A insegurança e a incerteza vêm perdendo espaço para pesquisas e atualizações no campo ao redor do mundo, e, mesmo com algumas barreiras a serem enfrentadas, seu crescimento tem possibilitado acesso, autonomia, economia financeira e qualidade.
Disfonia
Authors: Millas Ieda , Dias Fernanda Fidalgo , Menezes Márcia Helena Moreira , Cantisano Daniela Imbrosio , Soares Ana Luiza Vieira
Published: June 2023

Introdução: A disfonia causa impacto na qualidade de vida e no mercado de trabalho, sendo sintoma importante para triagem de neoplasia laríngea. Objetivo: Realizar avaliação estatística de um grupo populacional da cidade de Guarulhos com queixa de disfonia. Método: Trata-se de um estudo transversal com utilização de amostra correspondente a 2.564 exames, videolaringoscópicos ou nasofibrolaringoscópicos, de pacientes acima de 5 anos de idade, no município de Guarulhos da região metropolitana de São Paulo, pelo mesmo médico otorrinolaringologista e pelo mesmo fonoaudiólogo, entre os meses de abril de 2011 e abril de 2012. Avaliaram-se as alterações no diagnóstico da voz, levando em consideração idade e sexo dos pacientes. Foram descritos os sexos das pessoas segundo diagnósticos com uso de frequências absolutas e relativas e verificou-se a existência de associação entre sexo e diagnóstico através do uso de teste da razão de verossimilhanças (Kirkwood e Sterne, 2006). As idades foram descritas, segundo diagnósticos, com uso de medidas resumo (média, desvio-padrão (DP), mediana, mínimo e máximo), e foram comparadas as idades entre os diagnósticos, com uso de teste análise de variâncias (ANOVA) seguido de comparações múltiplas de Tukey (Neter et al., 1996). Os testes foram realizados com nível de significância de 5%. Resultados: Há maior frequência de homens com diagnóstico de neoplasias ou câncer que nos demais diagnósticos. Dos 2.564 exames, 477 apresentaram laringite crônica, sendo 69% do gênero feminino; 279 disfonia funcional, 63,4% do gênero feminino; 137 alterações estruturais mínimas (AEM), 69,3% do gênero feminino; 36 disfunções neurológicas, sendo igualmente divididos entre os gêneros; e 12 apresentaram neoplasias, sendo 83,3% do masculino. Conclusão: Verificou-se maior número de alterações benignas no gênero feminino. Neoplasias e disfunções neurológicas predominaram no gênero masculino. A disfonia funcional e as AEM ocorrem em pacientes abaixo dos 40 anos, enquanto as demais ocorrem até em idades avançadas, acima dos 50 anos.
De l’espace et des hommes : Identité de groupe et traces de la privatisation de l’espace et de la propriété à l’époque néolithique
Authors: Hammad Manar
Published: June 2023

Pour la période néolithique, la sédentarité des hommes est inférée de la présence de constructions durables groupées, identifiées comme villages, où des traces d’activité et de préparation alimentaire invitent à reconnaître des maisons et des bâtiments communautaires. La morphologie de ces structures atteste diverses formes du contrôle de l’accès physique et de l’accès visuel des gens aux espaces construits, ce qui est interprétable comme un ensemble de moyens matériels de privatisation : les formes de la circulation des personnes dans l’espace sont investies des effets de sens public ou privé. L’analyse commence par la partition de l’espace du village, passant ensuite à la partition de l’ensemble de ses habitants en groupes. Des unités spatiales sont identifiées par des rénovations successives, des unités sociales sont reconnues comme incluant des morts antérieurs et des nouveaux nés ultérieurs. La conjonction durative de ces deux catégories sert de base à la reconnaissance de formes précoces d’une propriété inaliénable. La qualité de propriété est discutée par la comparaison avec un modèle syntaxique de la propriété moderne du sol, identifiée comme la circulation d’unités spatiales au sein de l’espace social, la circulation étant décrite en termes d’acquisition, cession et transfert. L’analyse conclut que nous n’avons pas aujourd’hui de traces certaines de la propriété à la période néolithique. La certitude relative à la propriété privée apparaît avec l’écriture, lorsque des tablettes rendent compte de la circulation de biens immobiliers parmi les gens. Une telle conclusion peut être modifiée suite à de nouvelles trouvailles archéologiques ou à des progrès méthodologiques.
Le débat sur les catégories de genre : comment rendre les langues adéquates
Authors: Lorusso Anna Maria
Published: June 2023

Le débat sur le politiquement correct est très intéressant du point de vue sémiotique et sémantique. Il met en évidence le problème des conditions de la révision du langage, des limites des initiatives subjectives et de la résistance des usages devenus des normes. A travers quelques considérations relatives aux formules langagières liées au genre sexuel (de la distinction du féminin à une formule neutre telle que le « schwa »), l’article présente une réflexion sur le système linguistique en tant qu’espace de conflit social et de résistance normative.
Research of the influence of vibroactivated lime on the hydration of portland cement and its hardening
Authors:   Lviv Polytechnic National University, Borovets Z. I. , Lutsyuk I. V. ,   Lviv Polytechnic National University, Zahrai A. I. ,   Lviv Polytechnic National University
Published: June 2023

The influence of vibro-activated lime additive on the hydration processes of Portland cement and the nature of changes in the strength of cement stone at different stages of its hardening were studied. It was established that long-term storage of vibro-activated lime in a wet state does not weaken its properties as a modifying additive. The methods of determining the heat release of cement dough during hardening and X-ray phase analysis show that the addition of vibro- activated lime at the initial stages of hardening accelerates the physicochemical processes of hydration of calcium silicates of clinker minerals.
EFEKTIVITAS PELAKSANAAN KEBIJAKAN PENGURANGAN PENGGUNAAN KANTONG PLASTIK DI KOTA SUKABUMI
Authors: Prinardi Ghifary , Purwanti Dian , Fajar FY Basori Yana
Published: June 2023

Waste is a major pollution problem both globally and nationwide. One type of waste that is inherently persistent and  harmful to human health is plastic waste. Plastic is one of the materials found in almost every item. The Government of Sukabumi city has stipulated the Mayor's Regulation No. 19 of 2019 about reducing the use of plastic bags in order to minimize the generated plastic waste, prevent  environmental pollution caused by plastic waste and maintain environmental sustainability. The research used one variable, namely effectiveness, and applied the policy effectiveness theory proposed by Nugroho (51-54:2021) consisting of right policy indicators, right implementation, right target, right environment, and right process). The research employs one variable (1), the effectiveness variable.This research uses a Mixed Methods approach with a Conccurent Triangulation model. The research also deployed the z-test analysis technique. The result of the research on the level of policy effectiveness shows that the use of plastic bags reduction policy in Sukabumi City is considered to be very effective, gaining a percentage of 87.53%. Moreover, the result of the z-test acquires a calculated z value of 0.151, meaning that in the research, the result of the z-test is greater than the z-table namely amounted to 0.05; therefore, H1 is accepted, indicating that the effectiveness of the use of plastic bags reduction policy in Sukabumi City is effective
GREEN TOURISM CONCEPT FOR RECOVERY INDONESIAN TOURISM MODEL AFTER PANDEMIC COVID-19
Authors: Hastuti Ika Sri , Anggraini Melaty
Published: June 2023

Experiencing impact crisis, the number of tourists visiting Indonesia experience decreased, and had an impact on the occupancy of all hotels in Indonesia, which decreased by around 12.67% from the total in the previous year in 2019. A lot of energy work in the field of industry tourist experience bleaching consequence crisis that, recorded in the official site Kemenparekraf about 409 thousand power work housed. Adversity Industry tourist has implications for the inhibition developments in the sector others, such as continuity power work and business in the field of harmful tourism Indonesian economy.  Research methods, the author uses qualitative research with scheme begins with determining the objectives or questions that underlie the research Destinations tour the could made example or model for repair quality tourist bulk previously in the post- pandemic era because already carry draft tourist sustainable. Customized with addition the rules more Health protocols tight in the pandemic era with pattern application CHSE (Cleanliness, Healthy, Safety, and Environmental Sustainability) certification recommended by World Health Organization (WHO) as a standard for implementing tourism side by side with COVID -19 so that people who can travel feel safe and trust that journey tour the no will caught transmission of the Covid-19 virus. Emergency response mechanisms that disable economic activity, including that which may come from the tourism industry. due to the fact that the existence of lockdowns and the prohibition of outside activities In houses makes activity tours halt Many have been stopped in order to stop the virus's inflow and outflow before it destroys the tourism industry's business model.

Keywords: Tourism Strategy, Green Tourism, New Normal after pandemics
THE OPENNESS OF ACCESS AND BEHAVIOR OF DISPOSING OF GARBAGE ON THE RIVERBANKS
Authors: Nurhayati Ai , Burhanto Guruh
Published: June 2023

The people of Loji village have limited access to the riverbanks which makes them a place to live rubbish. The purpose of this study is to show what kind of behavior and access the village community Loji behaved to throw garbage on the riverbank. The method used is interview and observation. The results of this study found that the open access factor makes people feel now the riverbanks have become common property and are used together to be used as a place of waste disposal. The concepts of access and rational choice are used because they can explain the behavior of residents to dispose of waste that pollutes and damages the environment.
COMMUNITY EMPOWERMENT PLAN IN OVERCOMING MALNUTRITION
Authors: Achmad Willya
Published: June 2023

Malnutrition status in children is an important thing that must be known by every parent and malnutrition can affect children's brain development. Malnutrition status includes chronic nutritional problems caused by many factors such as socioeconomic conditions, maternal nutrition during pregnancy, illness in infants, and lack of nutritional intake in infants. To overcome this, the active role of the community is needed through a community empowerment plan. This study aims to investigate community empowerment plans in tackling malnutrition. This research will use qualitative methods with descriptive analysis. This research will also examine documents related to community empowerment programs in tackling malnutrition. The results of this study are expected to provide recommendations for related parties in the development of community empowerment programs that are more effective in tackling malnutrition.
FİLYOS VADİSİ PROJESİ’NİN SERBEST BÖLGELER BAĞLAMINDA BÖLGE VE ÜLKE EKONOMİSİNE OLASI KATKILARI
Authors: ARSLAN Ramazan , YILMAZ Mustafa
Published: June 2023

Serbest bölge, bir ülke sınırları içerisinde olup gümrük mevzuatının kısmen ya da hiç uygulanmadığı özel alanlar olarak tanımlanır. Serbest Bölgeler, devlet müdahalesinin minimum düzeyde olduğu aynı zamanda ticareti ve üretimi büyütmek için birtakım teşviklerin sağlandığı yerlerdir. Dünyada serbest bölgeler, büyük tüketim alanlarına yakın yerlerde oluşan ticaret kolonilerinin serbest alanlar oluşturması ile başlamıştır. İlk serbest liman örneği 1547 yılında İtalya’ da kurulmuştur. Türkiye’de ise 1985 yılında 3218 sayılı Serbest Bölgeler Kanununun yürürlüğe girmesi ile ilk serbest bölgeleri Mersin ve Antalya illerinde kurulmuştur. Filyos Vadisi Projesi, serbest bölge, serbest endüstri bölgesi, liman ve genişleme alanının tamamına verilen isimdir. Çalışmanın temel amacı, serbest bölgeler bağlamında Filyos Vadisi Projesi’nin bölge ve ülke ekonomisine olası katkılarını incelemektir. Bu amaçla nitel araştırma yöntemi tercih edilmiş, verilerin toplanmasında doküman analizi olarak basılı ve elektronik materyaller incelenmiş ve değerlendirilmiştir.

Ulusal bir yatırım projesi olan Filyos Vadisi projesi, bir enerji, teknoloji ve lojistik üssü haline gelmesiyle birlikte hem bölge hem de ülke ekonomisine özellikle yatırım, istihdam, ticaret ve enerji gibi temel konularda önemli katkılar sağlayacaktır.
B-cell Epitope Mapping of Capsid L1 from Human Papillomavirus to Development Cervical Cancer Vaccine Through In Silico Study
Authors: Rasyadan Taufiq Probojati  , Utami Santika Lusia , Turista Dora Dayu Rahma , Wiguna Arbi , Wijayanti Arini , Rachmawati Yuanita , Dibha Alyaa Farrah , Murtadlo Ahmad Affan Ali , Hasan Thobib , Listiyani Priscilla , Hafidzhah Muhammad Aldino , Hikam Agus Mohammad , Tamam Muhammad Badrut , Wijaya Renadya Maulani , Wahyuningsih Sri , Ullah Md.Emdad
Published: June 2023

Human papillomavirus (HPV) is a virus that plays an important role in the occurrence of cervical cancer. The HPV gene is composed of two parts: early and late gene. The L1 protein has a conserved region composed of cysteine ​​and lysine residues, both of which have involved in the binding process between virions and host receptors. Previous research has shown that vaccines can be developed based on epitopes that have conserved areas. This study is important to identify conserved protein sequences in L1 of HPV capsid, predict epitope mapping of B cells and antigenicity in the conserved region of L1 HPV capsid, as well as the similarity of amino acid residues of epitope composers with surface receptors of human body cells. The conserved areas were identified in L1 HPV as a potential epitope of B cells based on epitope mapping analysis of positions 23-46 and 97-119 with EGRGQPLGGSGHPNDDE DRDKQ and RHNGGPGPSGSSQFNKPYWAQGN peptides and each had a peptide length of 22-mer and 23-mer. The 97-119 epitope has a high antigenicity score and the similarity of the low amino acid residue sequence to the cell surface receptor of the human body, the 23-mer RHNGGPGPSGSSQFNKPYWAQGN peptide can be used as a reference for the development of cervical cancer prevention vaccine.
The Effects of the Maker Education Program Using Wood on Self-Directed Learning Abilities and Creative Problem-Solving Abilities for Elementary School Students
Authors:   The Korean Association of Practical Arts Education, Kang Byung-ju , Jung Jin-hyun
Published: June 2023

The purpose of this study is to verify the possible effects of the maker education program using wood on elementary school students’ abilities to creatively solve problems and develop self-direct learning abilities. The subjects of this paper were two fourth grade classes in an elementary school located in D city who participated in 10 courses. As test tools, self-direct learning abilities and creative problem-solving abilities were used. The SPSSWIN program was acquired for data analysis, and t-tests were performed to verify possible differences in self-direct learning abilities and creative problem-solving skills between the experimental and comparative groups.
The main research results of the present analysis are three-fold.
First, the average of all sub-areas of self-direct learning abilities in the experimental group improved significantly compared to the comparative group. In other words, the maker education program using wood had a positive effect on the improvement of elementary students’ self-direct learning abilities.
Second, the average of all sub-areas of creative problem-solving abilities in the experimental group improved by a considerable difference compared to the comparative group. It was found that the maker education program using wood had a positive effect on improving students’ creative problem-solving abilities.
Third, in the maker education program using wood, students took the lead in participating in the program and showed pride and attachment to their creations.
Therefore, the present analysis concluded that the maker education program using wood had a positive effect on both self-direct learning and creative problem-solving abilities of elementary school students.
Bruno Latour’s Detour
Authors: Van’t Land Andrew R.
Published: June 2023

In this article, I argue that the work of Bruno Latour has straddled two conflicting intellectual traditions: the relativism of 20th-century postmodernism (which deconstructed the realist pretensions of scientism) and the realism of 21st-century New Materialism (which seeks to sublate the postmodern linguistic turn and embrace science alongside critical theory). I connect these twin tendencies to their ancient precursors among the Greek sophists and presocratic philosophers and argue that Latour’s strange position between relativism and realism recalls the historical tension between the philosophical and rhetorical traditions. Latour has embodied both of these intellectual currents, shifting only his focus but never his commitment to deconstructing the distinction between nature and culture. By connecting the conflicting tendencies of postmodernism and New Materialism back to the ancient sophists and presocratic philosophers, I argue that Latour effectively ontologizes rhetorical persuasion as the ‘language’ of every being, human and nonhuman alike.
Comparison Between Several Ways of Defining Lebesgue’s Integral After Lebesgue
Authors: Biacino Loredana
Published: June 2023

After the publication in 1904 of Lebesgue’s Leçons, many mathematicians had the idea of obtaining a simpler and more natural theory of integration, sometimes for a technical or philosophical purpose, sometime for a didactical purpose. Among them Borel, Riesz, Young, Hahn, Pierpoint, Radon, Fréchet, Daniell and in Italy Tonelli, Vitali, Caccioppoli dealt with this fundamental tool. In this paper, their theories are exposed and compared.
PENGARUH BAURAN PEMASARAN TERHADAP KEPUASAN PASIEN DI APOTEK RAHMA KRIAN SIDOARJO
Authors: Intan Kurnia Permatasari  , Fadillah Tamammya Anshory
Published: June 2023

Marketing strategy is a way to achieve goals precisely by fulfilling the needs and desires of consumers through the exchange of goods or services. This study aims to determine the effect of the marketing mix with product, price, place, and promotion variables on patient satisfaction at Apotek Rahma. The type of research used is quantitative observation with a sample of 114 respondents and was conducted at the Rahma Krian Pharmacy Sidoarjo. The data collection technique uses a questionnaire that will be distributed to patients who will come to the pharmacy or who will consult a doctor. The analysis technique uses validity test, reliability test, multiple linear regression test, classical assumption test, and T test (partial), F test (simultaneous). The results showed that product and price variables had no effect on patient satisfaction, but place and promotion had an effect on patient satisfaction. Based on joint or simultaneous test, product, price, place, and promotion variables have a significant effect on patient satisfaction.
REPEAT ORDER RECOMMENDATION MODEL TO DIGITALIZE THE CANTEEN
Authors: Absari Dhiani Tresna , Liliana Liliana , Soesanto Daniel , Susana Limanto
Published: June 2023

The canteen is a campus facility that the academic community needs. However, because it is considered a complementary facility, business processes in the canteen are carried out conventionally, relying on paper-based recording. In addition, at certain hours, especially at lunchtime, the canteen is overloaded due to too many orders co-occurring. This buildup of charges is due to the need for canteen preparation in preparing orders from its buyers. Therefore, this study developed an ordering system to recommend the menus that customers likely purchase. The case study used in this research is the Keluwih canteen on the Tenggilis campus, owned by the University of Surabaya. This research used the waterfall method and focused on three main canteen processes: online ordering with a repeat order recommendation model for sellers, delivery services, and payments using the e-wallet. The study's results were assessed qualitatively, and the respondents felt they got better and faster service. Furthermore, with this system's e-canteen application, the time needed to complete a transaction at the campus canteen can be done efficiently to increase customer satisfaction and employee productivity from tenants.
PENGARUH PENGETAHUAN, SOSIALISASI, DAN SANKSI PERPAJAKAN TERHADAP KEPATUHAN WAJIB PAJAK ORANG PRIBADI
Authors: Mutiara  , Levi Martantina
Published: June 2023

This study aims to determine the relationship between Tax Knowledge owned by online store owners, socialization that has been obtained, and the sanctions that have been set affect compliance in paying final income tax. The population in this study are Kpop online store owners who sell physical and Kpop merchandise. This study uses one dependent variable represented by Taxpayer Compliance and three independent variables represented by Knowledge, Socialization, and Tax Sanctions. Data was obtained by distributing questionnaires, after which the data was calculated using statistical methods with the help of the Statistical Program For Social Science (SPSS).