bluuebunny/crossref_metadata_2025 huggingface dataset:
Assessment and Prognostic Significance of a Serum Cytokine Panel in Diffuse Large B-cell Lymphoma
Authors: xie shufang , Zhu Lifen , Wang Lei , Wang Shibing , Tong Xiangmin , Ni Wanmao
Published: May 2023

ObjectiveTo assess the contents of circulating cytokines in patients with diffuse large B-cell lymphoma (DLBCL), and to examine their relationship with clinicopathological manifestations and prognosis.MethodWe recruited 72 DLBCL patients, 11 chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) patients, and 56 healthy controls from our hospital between the period of January 2017 and January 2020, and measured 7 serum cytokine contents using Beckman Navios flow cytometry. The cytokine level was compared between DLBCL patients and healthy controls using one way ANOVA. Two-sided Spearman test was employed for relationship evaluation between circulating cytokine levels and clinicopathological characteristics, IPI score, and short-term treatment response within DLBCL patients. The inter-group comparison of cytokine levels employed the Mann Whitney test. The support vector machine (SVM) was utilized for the cytokine evaluation-based prediction of DLBCL patient short-term treatment response. Lastly, survival curves were used to assess correlation between the aforementioned cytokines and overall survival.ResultThe IL-6, IL-10, and IFN-γcontents were markedly enhanced among DLBCL patients, as opposed to healthy controls (P < 0.05). Patients with enhanced circulating LDH expressed elevated IL-10 level (P < 0.05), and patients with augmented CRP expressed upregulated IL-6 and IL-10 levels, and the rise in IL-6 levels was positively associated with serum CRP (P = 0.00,r = 0.66). Additionally, the international prognostic index (IPI) risk stratification of DLBCL patients was strongly associated with the circulating IL-6 and IL-10 contents. Enhanced IL-6, IL-10, and TNF-α levels often produced worse short-term treatment efficacies (P < 0.05). Moreover, the accuracy of short-term treatment response prediction model of DLBCL patients, obtained using SVM, was 81.63%. Using long-term follow-up, we further revealed that the DLBCL patients who expired within one year exhibited enhanced circulating IL-6 and IL-10 levels, compared to patients who survived, however, the IL-17 level was drastically reduced (P < 0.05). Despite the aforementioned evidences, we observed no marked association between the specified cytokines and overall survival (OS).ConclusionThe IL-6, IL-10, IL-17, TNF-α, and IFN-γ contents can potentially serve as biological indicators of DLBCL tumor immune status, and a combined application with the IPI score can be a robust indicator for DLBCL patient prognosis. Our findings provide novel ideas for the clinical treatment of DLBCL patients.
Investigating the antibacterial, anti-motility and anti-biofilm potential of Syzygium cumini mediated silver nanoparticles against emerging multi-drug resistant nosocomial pathogens
Authors: Diksha Diksha , Pai Manju Ohri , Gupta Pratima , Verma Sahil , Banerjee Uttam Chand , Kalita Deepjyoti
Published: May 2023

The current landscape of antibiotic failures promotes researchers to turn their attention to nanotechnology. Therefore, in this study silver nanoparticles (AgNPs) were synthesized by using the leaf extract of Syzygium cumini. The spectrum of biosynthesized silver nanoparticles was noticed at 432 nm displaying a bell-shaped curve under UV-Vis spectroscopy. Transmission electron microscopy (TEM) showed that these nanoparticles have a spherical shape and diameter of 50–60 nm. FT-IR study has revealed the presence of phenolics, aromatic, and alkynes groups in the synthesized nanoparticles. These biosynthesized AgNPs were processed for antibacterial,anti-motility, and anti-biofilm activity. Results showed that AgNPs exhibit good antibacterial activity. A significant reduction in motility patterns has been visualized by the effect of AgNPs against P. aeruginosa and A. baumannii. Substantial and structural reduction in P. aeruginosa and A. baumannii biofilm morphology was also examined by the effect of AgNPs. Hence greener route of AgNPs synthesis may be validated as a feasible substitute in eliminating the infection caused by multi-drug resistant nosocomial pathogens.
Bobcat339, a specific TET family inhibitor, impaired oocyte maturation and early embryogenesis in pig
Authors: Chen Fan , Li Mingguo , Hua Zaidong , Ren Hongyan , Luo Anfeng , Gu Hao , Zhou Changfan , Zhu Zhe , Huang Tao , Bi Yanzhen
Published: May 2023

Background: Ten-eleven translocation (TET) enzyme family, which includes TET1/2/3, participates in active DNA demethylation in the eukaryotic genome; however, TET1/2/3 are functionally redundant. The effect of TET1/2/3 triple-gene knockdown or knockout on the porcine oocytes and embryos is unclear. In this study, using Bobcat339, a specific small-molecule inhibitor of the TET family, we explored the combined effects of TET enzymes on oocyte maturation and early embryogenesis in pigs.
Method: First, porcine cumulus oocyte complexes were cultured in the IVM medium with various concentrations of Bobcat339, and the effects on the expansion of cumulus cells and oocyte maturation were investigated. Further, the apoptotic level of oocytes was assessed using RT-PCR and Annexin-V staining. The spindle architecture and chromosomal alignment were investigated using immunofluorescence staining. Furthermore, the fluorescent signals of 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) were quantified. Subsequently, the effect of Bobcat339 on porcine parthenogenetic embryos was assessed. We recorded the blastocyst formation and developmental rates. Furthermore, the mRNA levels of zygotic gene activation (ZGA)- and pluripotency-related and imprinted genes were assessed using RT-PCR. Finally, RNA sequencing analysis was performed in the embryos at the 4-cell stage to identify differentially expressed genes.
Result: Our results revealed that Bobcat339 treatment blocked porcine oocyte maturation and triggered early apoptosis. Furthermore, in the Bobcat339-treated oocytes, spindle architecture and chromosome alignment were disrupted, probably due to huge loss of 5hmC and concurrent increase in 5mC. Furthermore, after Bobcat339 treatment, early parthenogenetic embryos exhibited abnormal 5mC and 5hmC levels, which resulted in compromised cleavage and blastocyst rate. The mRNA levels of EIF1A and DPPA2 (ZGA marker genes) were significantly decreased, which may explain why the embryos were arrested at the 4-cell stage after Bobcat339 treatment. In addition, the mRNA levels of pluripotency-related genes OCT4 and NANOG were declined after Bobcat339 treatment. RNA sequencing analysis revealed differentially expressed genes in Bobcat339-treated embryos at the 4-cell stage, which were significantly enriched in cell proliferation, cell component related to mitochondrion, and cell adhesion molecule binding.
Conclusion: Our results indicated that TET proteins are essential for porcine oocyte maturation and early embryogenesis, and they act by mediating 5mC/5hmC levels and gene transcription.
Synergistic antibacterial action of the iron complex and ampicillin against Staphylococcus aureus
Authors: Kosaristanova Ludmila , Rihacek Martin , Sucha Frantiska , Milosavljevic Vedran , Svec Pavel , Dorazilova Jana , Vojtova Lucy , Antal Peter , Kopel Pavel , Patocka Zdenek , Adam Vojtech , Zurek Ludek , Dolezelikova Kristyna
Published: May 2023

Objectives Resistance to antibiotics among bacteria of clinical importance, including Staphylococcus aureus, is a serious problem worldwide and the search for alternatives is needed. Some metal complexes have antibacterial properties and when combined with antibiotics, they may increase bacterial sensitivity to antimicrobials. In this study, we synthesized the iron complex and tested it in combination with ampicillin (Fe16 + AMP) against S. aureus.Methods An iron complex (Fe16) was synthesized and characterized using spectroscopy methods. Confirmation of the synergistic effect between the iron complex (Fe16) and ampicillin (AMP) was performed using ζ–potential, infrared spectra and FICI index calculated from minimum inhibitory concentration (MIC). Cytotoxic properties of combination Fe16 + AMP was evaluated on eukaryotic cell line. Impact of combination Fe16 + AMP on chosen genes of S. aureus were performed by Quantitative Real-Time PCR.Results The MIC of Fe16 + AMP was significantly lower than that of AMP and Fe16 alone. Furthermore, the infrared spectroscopy revealed the change in the ζ–potential of Fe16 + AMP. We demonstrated the ability of Fe16 + AMP to disrupt the bacterial membrane of S. aureus and that likely allowed for better absorption of AMP. In addition, the change in gene expression of bacterial efflux pumps at the sub-inhibitory concentration of AMP suggests an insufficient import of iron into the bacterial cell. At the same time, Fe16 + AMP did not have any cytotoxic effects on keratinocytes.Conclusions Combined Fe16 + AMP therapy demonstrated significant synergistic and antimicrobial effects against S. aureus. This study supports the potential of combination therapy and further research.
Factor mixture modelling of depression and anxiety: Associations with common mental health disorders, service use, and functional impairment
Authors: Brattmyr Martin , Lindberg Martin Schevik , Lundqvist Jakob , Solem Stian , Hjemdal Odin , Anyan Frederick , Havnen Audun
Published: May 2023

Background: Patient-reported outcome measures (PROM) provide clinicians with information about patients’ perceptions of distress. When linked with treatment and diagnostic registers, new information may be obtained, such as associations with prevalence and service use. This study aimed to examine psychological symptoms among psychiatric outpatients and to investigate treatment-relevant characteristics of symptom-homogeneous classes.
Methods: In a cohort study of 2473 (63% female) outpatients, factor mixture modelling (FMM) was used to analyse self-reported symptoms of anxiety and depression before treatment, and the classes association with functional impairment, the prevalence of common mental health disorders (CMHD) and the number of assessments and psychotherapy appointments one year after treatment start.
Results: Overall, 22% of patients with a CMHD had an additional comorbid mood/anxiety disorder. This comorbid group reported higher symptoms of anxiety and depression compared to patients with non-comorbid anxiety disorders. FMM revealed three classes: “anxiety and somatic depression” (33%), “mixed depression and anxiety” (40%), and “cognitive depression” (27%). The anxiety and somatic depression class was associated with older age, being single and on sick leave, higher probability of depressive-, anxiety-, and comorbid disorders, having more appointments and higher functional impairment. Although the cognitive depression class had less somatic distress than the mixed depression and anxiety class, they reported more functional impairment and had higher service use.
Conclusions: The results demonstrate the clinical relevance of applying FMM to PROM data of depression, anxiety, and functional impairment when linked with treatment registers. Three patient groups emerged, with different symptom patterns. Higher symptom severity did not necessarily imply more functional impairment and service use when subdimensions and latent patient groups were accounted for.
Development of a radiomic-clinical nomogram for prediction of survival in patients with diffuse large B-cell lymphoma treated with chimeric antigen receptor T cells
Authors: zhou yeye , Zhang Bin , Han Jiangqin , Dai Na , Jia Tongtong , Huang Haiwen , Deng Shengming , Sang Shibiao
Published: May 2023

Background In our current work, an 18F-FDG PET/CT radiomics-based model was developed to assess the progression-free survival (PFS) and overall survival (OS) of patients with relapsed or refractory (R/R) diffuse large B-cell lymphoma (DLBCL) who received chimeric antigen receptor (CAR)-T cell therapy.Methods A total of 61 DLBCL cases receiving 18F-FDG PET/CT before CAR-T cell infusion were included in the current analysis, and these patients were randomly assigned to a training cohort (n = 42) and a validation cohort (n = 19). Radiomic features from PET and CT images were obtained using LIFEx software, and radiomics signatures (R-signatures) were then constructed by choosing the optimal parameters according to their PFS and OS. Subsequently, the radiomics model and clinical model were constructed and validated.Results The radiomics model that integrated R-signatures and clinical risk factors showed superior prognostic performance compared with the clinical models in terms of both PFS (C-index: 0.710 vs. 0.716; AUC: 0.776 vs. 0.712) and OS (C-index: 0.780 vs. 0.762; AUC: 0.828 vs. 0.728). For validation, the C-index of the two approaches was 0.640 vs. 0.619 and 0.676 vs. 0.699 for predicting PFS and OS, respectively. Moreover, the AUC was 0.886 vs. 0.635 and 0.778 vs. 0.705, respectively. The calibration curves indicated good agreement, and the decision curve analysis suggested that the net benefit of radiomics models was higher than that of clinical models.Conclusions PET/CT-derived R-signature could be a potential prognostic biomarker for R/R DLBCL patients undergoing CAR-T cell therapy. Moreover, the risk stratification could be further enhanced when the PET/CT-derived R-signature was combined with clinical factors.
Active Control Time: An Objective Performance Metric For Trainee Participation in Robotic Surgery
Authors: Clanahan Julie M. , Yee Andrew , Awad Michael M.
Published: May 2023

Background Trainee participation and progression in robotic general surgery remains poorly defined. Computer-assisted technology offers the potential to provide and track objective performance metrics. In this study, we aimed to validate the use of a novel metric—active control time (ACT)—for assessing trainee participation in robotic-assisted cases.Materials and Methods Performance data from da Vinci Surgical Systems was retrospectively analyzed for all robotic cases involving trainees with a single minimally invasive surgeon over 10 months. The primary outcome metric was percent ACT—the amount of trainee console time spent in active system manipulations over total active time from both consoles. Kruskal-Wallis and Mann-Whitney U statistical tests were applied in analyses.Results A total of 123 robotic cases with 18 general surgery residents and 1 fellow were included. Of these, 56 were categorized as complex. Median %ACT was statistically different between trainee levels for all case types taken in aggregate (PGY1s 3.0% [IQR 2–14%], PGY3s 32% [IQR 27–66%], PGY4s 42% [IQR 26–52%], PGY5s 50% [IQR 28–70%], fellow 61% [IQR 41–85%], p = < 0.0001). When stratified by complexity, median %ACT was higher in standard versus complex cases for PGY5 (60% v 36%, p = 0.0002) and fellow groups (74% v 47%, p = 0.0045).Conclusions In this study, we demonstrated an increase in %ACT with trainee level and with standard versus complex robotic cases. These findings are consistent with hypotheses, providing validity evidence for ACT as an objective measurement of trainee participation in robotic-assisted cases. Future studies will aim to define task-specific ACT to guide further robotic training and performance assessments.
Phosphorus fertilization affects litter quality and enzyme activity in a semiarid grassland
Authors: Gong Jirui , Dong Xuede , Li Xiaobing , Yue Kexin , Shi Jiayu , Song Liangyuan , Zhang Zihe , Zhang Weiyuan , Li Ying
Published: May 2023

Aims Litter decomposition affects soil organic carbon storage, and nutrient addition alters exogenous nutrient availability in soil, thereby affecting the endogenous nutrient concentration and extracellular enzyme activity in litter. However, how above- and belowground litter decomposition responds to nutrient addition is not fully understood.
Methods We conducted a 7-yr field experiment with 5 levels (0, 1, 2.5, 5, and 12.5 g P m-2 yr-1) of phosphorus fertilization (P). Starting in the 6th year, we determine litter decomposition, nutrient elements, and enzyme activity to explore the response mechanisms of above- and belowground litter decomposition to P addition.
Results All levels of P addition increased the rate of aboveground litter decomposition, but only 2.5 g P m−2 yr−1 increased that of belowground litter. P addition increased the litter initial P and Mn contents, while decreased the C/P and N/P ratios of aboveground litter, which stimulated the activities of β-1,4-glucosidase and β-1,4-N-acetylglucosaminidase, thereby increasing the aboveground litter decomposition rate. The belowground litter decomposition was mainly inhibited by lignin content, and 2.5 g P m−2 yr−1 addition significantly decreased lignin content and increased the phenol oxidase activity, thereby accelerating the decomposition. P addition promoted the accumulation of P and the release of cellulose in aboveground litter and promoted the accumulation of calcium and the release of carbon in belowground litter.
Conclusions The different mechanisms of above- and belowground litter decomposition under P addition were driven by litter quality and enzyme activity, facilitating the understanding of the soil and plant interaction mechanisms in grassland ecosystems.
Source Rock Characterisation and Petroleum System Modelling a Review of Marginal Marine Deposit in the Permo-Triassic Sydney Basin, Australia
Authors: Garba Terfa Elijah , Mustapha Khairul Azlan
Published: May 2023

The marginal marine deposits signature is evident in the Permo-Triassic basins, the Sydney Basin is not an exception, and has not been subjected to source rock characterisation and petroleum system modelling designed at determining the potentials of hydrocarbon resources and its prospectivity. The economic potentials of the marginal marine environment are great, with enormous information in the literature that deals with the development of these deposits. The wide use of major, trace, and rare earth elements for basin analysis studies to unravel the geochemical signatures of sedimentary succession using the discriminatory diagrams fall short of addressing discriminate sediments from different geotectonic environments consequently a lag in source rock characterisation and petroleum system model of the marginal marine deposits. This review provides new insight into source rock, sediment supply, and depositional patterns of the marginal marine deposits in the Permo-Triassic Sydney Basin and its implication to the dearth in petroleum prospectivity.
A new deep neural network for forecasting: Deep dendritic artificial neural network
Authors: Egrioglu Erol , Bas Eren
Published: May 2023

Deep artificial neural networks have become a good alternative to classical forecasting methods in solving forecasting problems. Popular deep neural networks classically use additive aggregation functions in their cell structures. It is available in the literature that the use of multiplicative aggregation functions in shallow artificial neural networks produces successful results for the forecasting problem. A type of high-order shallow artificial neural network that uses multiplicative aggregation functions is the dendritic neuron model artificial neural network, which has successful forecasting performance. The first contribution of this work is the transformation of the dendritic neuron model, which works with a single output in the literature, into a multi-output architecture. The second contribution is to propose a new dendritic cell based on the multi-output dendritic neuron model for use in deep artificial neural networks. The other most important contribution of the study is to propose a new deep artificial neural network, a deep dendritic artificial neural network, based on the dendritic cell. The training of the deep dendritic artificial neural network is carried out with the differential evolution algorithm. The forecasting performance of the deep dendritic artificial neural network is compared with basic classical forecasting methods and some recent shallow and deep artificial neural networks over stock market time series. As a result, it has been observed that deep dendritic artificial neural network produces very successful forecasting results for the forecasting problem.
Latent Class Analysis of Mathematics/Science Students Metacognitive Learning Strategies in College of Education in Volta Region, Ghana
Authors: Kumah Maxwell Seyram
Published: May 2023

Metacognitive learning refers to the process of being aware of and taking control of one's own learning. Research has shown that effective use of metacognitive learning strategies can lead to improved student learning outcomes. It helps student to set SMART goal, monitor their own progress, encouraging students to reflect on their own learning and providing feedback that is specific, constructive, and timely can help students to identify areas where they need to improve. The study focused on mathematics/science student’s metacognition utilization in Colleges of Education in Volta region of Ghana. Of 323 population, 139 were purposively and randomly sampled for the study using quantitative exploratory cross – sectional survey design. Twenty – five question items using Metacognitive Learning Utilization Questionnaire (MLUQ) relating to planning, monitoring, evaluation, self-regulation and comprehension was used for data collection. The latent class analysis (LCA) suggests the three-class solution as the accepted best fitting model, based on statistical fit indicators AIC, BIC, entropy, Gsq, and Chsq. The result revealed that comprehension, monitoring and evaluation were very good, and averagely good respectively utilised by majority while self – regulation and planning were satisfactorily and poorly utilised by students. The variables were tested using one way ANOVA with high, moderate and low-level utilization. It was found that there was a statistically significant difference between all three-class based on the mean difference. The study indicate that comprehension was highly utilized while planning was the lowest utilized component of metacognitive learning strategy. Is therefore, recommended student should be supported with metacognitive learning awareness with focus on planning and self-regulation. Other implications of the findings are discussed.
Macromolecular crowding affects protein diffusion in stress fibers as revealed by fluorescence correlation spectroscopy
Authors: Buenaventura Aria , Saito Takumi , Kanao Taiga , Matsunaga Daiki , Matsui Tsubasa S. , Deguchi Shinji
Published: May 2023

The diffusion of cell components such as proteins is crucial to the function of all living cells. The abundance of macromolecules in the cell is likely to cause a state of macromolecular crowding, but its effects on the extent of diffusion remain poorly understood. Here we investigate the diffusion rate in three distinct locations in mesenchymal cell types, namely the cytoplasm, the stress fibers, and those below the nucleus using three kinds of inert green fluorescent proteins (GFPs), namely a monomer, dimer, and trimer GFP. Fluorescence correlation spectroscopy (FCS) was used to determine the diffusion coefficients. We show that diffusion tends to be lowered on average in stress fibers and is significantly lower in those located below the nucleus. Our data suggests that the diffusive properties of GFPs, and potentially other molecules as well, are hindered by macromolecular crowding. However, although the size dependence on protein diffusion was also studied for monomer, dimer, and trimer GFPs, there was no significant difference in the diffusion rates among the GFPs of these sizes. These results could be attributed to the lack of significant change in protein size among the selected GFP multimers. Nevertheless, the data presented here would provide a basis for better understanding of complicated protein diffusion in the nonuniform cytoplasm and in turn of cellular responses to mechanical stress as well as their local mechanical properties.
Enhancing Heliostat Calibration on Low Data by Fusing Robotic Rigid Body Kinematics with Neural Networks
Authors: Pargmann Max , Leibauer Moritz , Nettelroth Vincent , Quinto Daniel Maldonado , Pitz-Paal Robert
Published: May 2023

Solar tower power plants rely on precise calibrations of their heliostats for efficient operation. Open-loop calibration procedures are the most common type due to their cost-effectiveness. Two main approaches to these algorithms exist: geometry-based robotic kinematics and neural network-based models. While the former is reliable and requires little data, it only yields moderate accuracy. The latter, however, promises higher accuracies but is data-hungry and unreliable. In this study, we propose a 2-layer coarse-to-fine hybrid model that combines the strengths of both approaches. Our model uses a rigid-body model for prealignment, then phases in a neural network disturbance model through a regularization sweep. This approach ensures that the prediction accuracy is, in the worst-case, equivalent to that of the rigid-body model. Moreover, it helps to identify deficiencies that may have been overlooked by the physical approach. It especially is capable to compute deviation from the geometry models averaged optimum. For testing, we used real measurement data from daily heliostat calibration at the solar tower in Jülich. We also employed a training/validation data split for evaluation, which allows for a conservative performance assumption over the entire year. Our results demonstrate that the hybrid-model outperforms rigid-body models starting from the first measurement, achieving a top performance below 0.7 milliradians. In conclusion, our proposed hybrid model provides a cost effective in-situ solution for heliostat calibration with highest accuracies on low data in solar tower power plants for all open loop calibration methods.
Approximation through suffixation: -ḍḍu/-a in Sicilian
Authors: Brucale Luisa , Mocciaro Egle
Published: May 2023

This article investigates the use of the Sicilian suffix -ḍḍu/-a for the expression of approximation. On the basis of a survey of a corpus of ethnotexts and the outputs of a translation questionnaire, we propose that approximation is a core value in the semantic network of the suffix, expressing a certain distance from the default values conveyed by the base. In terms of prototypicality, this distance may occur from the categorial centre (internal approximation): the suffix modifies the semantics of the base but does not alter the categorial status of the referent. Alternatively, the suffix may impact on categorial membership tout court (external approximation), questioning the categorial properties of the base. Based on this classification, the semantic cores of the suffix are represented in a map showing the connections between the various meanings identified in the corpus.
Le droit suisse des sociétés en 2021 : Modifications législatives et jurisprudence
Authors: Canapa Damiano , Grisoni Arthur , Antonoff Marine
Published: May 2023

Cette contribution propose un aperçu des principales modifications législatives et de la jurisprudence du Tribunal fédéral [TF] de l'année 2021 en droit suisse des sociétés. La section consacrée aux modifications législatives (chiffre I) revient sur l'entrée en vigueur des modifications du CO et d'autres lois relatives au droit commercial tandis que les résumés de jurisprudence font l'objet de la section suivante (chiffre II) ; les arrêts y sont classés par forme de société et les arrêts publiés au recueil des ATF précèdent les autres arrêts, qui sont classés par ordre chronologique.

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Dieser Beitrag bietet einen Überblick über die wichtigsten Gesetzesänderungen und die Rechtsprechung des Bundesgerichts für das Jahr 2021 im Schweizer Gesellschaftsrecht. Der Abschnitt über die Gesetzesänderungen (Ziffer I) geht auf das Inkrafttreten der Änderungen des OR und anderer handelsrechtlicher Gesetze ein, während die Zusammenfassungen der Rechtsprechung Gegenstand des darauffolgenden Abschnitts (Ziffer II) sind. Die Urteile sind dort nach Gesellschaftsform geordnet und die in der amtlichen Sammlung des Bundesgerichts publizierten Leitentscheide (BGE) gehen den anderen Urteilen, die chronologisch geordnet sind, voraus.
PENGARUH KERAMAHAN KARYAWAN, PEMAHAMAN TENTANG PRODUK, DAN KERAGAMAN ITEM PRODUK TERHADAP LOYALITAS KONSUMEN MELALUI KEPUASAN KONSUMEN PADA ALFAMART DI WILAYAH KOTA SURABAYA
Authors: Anggitaningsih Retna
Published: May 2023

This study aims to explain the effect of employee friendliness, understanding of the products sold, and the diversity of product items on consumer loyalty through consumer satisfaction at Alfamart in the city of Surabaya. The object of observation is consumers who visit Alfamart to shop. In this study, observations were made of 200 consumers who were shopping at Alfamart stores, provided that the consumer has made purchases at least five times at any Alfamart store in Surabaya. The analytical method used is the structural equation model (SEM), with exogenous variables: friendliness of salespeople; the salesperson's understanding of the products, and the completeness and variety of available product items; endogenous variables: consumer loyalty; and the intervening variable: consumer satisfaction. The compared models are model-1, where loyalty is positioned as an endogenous variable with customer satisfaction as an intervening variable, and model-2, where customer satisfaction is an endogenous variable with loyalty as an intervening variable. The findings and results of the study indicate that: (1) the friendliness of the salesperson has a significant positive effect on customer satisfaction; (2) customer satisfaction has a significant positive effect on loyalty; and (3) from the comparison of the two models, it can be stated that the better model in explaining the phenomenon under study is model-1. Thus, these findings further support the theory that loyalty arises after a person feels satisfied.
COOKING OIL PRICE CONTROL POLICY IN INDONESIA (A review of Ibn Taimiyah's thoughts)
Authors: Huda Eva Nurul , Sidiq Sahabudin
Published: May 2023

This study aims to analyze cooking oil price control policies in Indonesia by examining Ibn Taimiyah's thoughts about market mechanisms and price interventions. The research method used is a qualitative research methodology with a literature study approach. The research results show that the market mechanism in Islam is free of any intervention. However, the government can intervene in market prices when distortions occur. The government's policy of providing cooking oil subsidies to the less fortunate and setting the lowest retail price is permissible because there are conditions where producers do not want to sell their goods except at a price higher than the general market price, even though consumers really need these goods. According to Ibnu Taimiyah, the government may intervene in prices and limit sales after conducting negotiations, discussions, and consultations with interested communities.
URGENSI DAN PERAN LEMBAGA KEUANGAN MIKRO DALAM PENGENTASAN KEMISKINAN DAN PENGEMBANGAN EKONOMI UMAT
Authors: Suaidah Suaidah , Arjun Devi
Published: May 2023

Layanan keuangan mikro semakin meningkat dan telah menjadi intervensi yang populer melawan kemiskinan di negara berkembang. Kemampuan Lembaga Keuangan Mikro telah teruji melalui masa krisis moneter yang sangat sulit dan terbukti secara riskan mampu memberdayakan perekonomian kecil dan menengah. Oleh karena itu, peneliti ingin mengkaji bagaimana peran LKM dalam pengentasan kemiskinan dan pengembangan pemberdayaan ekonomi umat. Karena LKM saat ini semakin berkembang serta telah membawa perubahan yang mendasar pada strategi sosialisasi.  Metode penelitian bersifat penelitian kualitatif dengan menggunakan pendekatan studi pustaka. Hasil dari penelitian menemukan bahwa salah satu peran yang sangat besar dalam pengentasan kemiskinan saat ini adalah BMT yang saat ini masih dipercaya oleh masyarakat. Hal ini diminati, karena lembaga keuangan syariah oleh umat Islam bahkan umat non muslim sekalipun, sebab berprinsip jujur, adil dan baik yang selalu menjadi daya tarik masyarakat.
Synthesis and Evaluation of the Antileishmanial Activity of Novel Eugenol Analogs Containing 1,2,3-Triazole Fragments against Intracellular Leishmania braziliensis
Authors: Evangelista Roberta , Pereira Larissa , de Souza Luciana , Costa Adilson , da Silva Danilo , de Oliveira Fabrício , Vaz Boniek , Bressan Gustavo , Fietto Juliana , Teixeira Róbson
Published: May 2023

This investigation describes the synthesis of eugenol analogs presenting 1,2,3-triazole fragments and evaluation of their antileishmanial activity. The alkylation of guaiacol (1) with allyl bromide afforded 1-(allyloxy)-2-methoxybenzene (2) (93% yield). The Claisen rearrangement conducted with 1 gave ortho eugenol (3) (82% yield). Alkylation procedures performed with 3 produced 1-allyl3-methoxy-2-(prop-2-yn-1-yloxy)benzene (4) (73% yield) and 1-allyl-3-methoxy-2-(pent-4-yn1-yloxy)benzene (6) (53% yield). The copper(I)-catalyzed alkyne-azide cycloaddition (CuAAC) reactions involving alkynes 4 and 6 with different benzylic azides afforded twenty-two eugenol analogs with 1,2,3-triazole functionalities (48-93% yield). We screened the compounds at 10 μmol L-1 against Leishmania braziliensis intracellular amastigotes during macrophage infection. The action of these compounds was compared with the known leishmanicidal drug amphotericin B. None of the analogs were toxic to macrophages at 10 μmol L-1. The cytotoxic concentration at 50% (CC50), effective concentration at 50% (EC50), and selectivity index (SI) were determined to the best compounds 4-((2-allyl-6-methoxy)phenoxymethyl)-1-(4-chlorobenzyl)-1H-1,2,3-triazole (8c) and 4-((2-allyl-6-methoxy)phenoxymethyl)-1-(4-trifluoromethoxybenzyl)-1H-1,2,3-triazole (8h). They showed a significant leishmanicidal effect, with EC50 of 28.09 µmol L-1 (8c) and 52.03 µmol L-1 (8h). The SIs were 9.7 for 8c and > 5.7 for 8h. These compounds have the potential as new leishmanicidal agents against L. braziliensis and may represent a starting point for the development of alternative treatments for cutaneous leishmaniasis.
La existencia de Dios y la esencia de la verdad: el argumento ontológico de San Anselmo a la luz de Heidegger
Authors: Crichton Cristina
Published: May 2023

En este artículo ofrezco una nueva interpretación del argumento ontológico de San Anselmo. Mi propósito es demostrar que la importancia de este argumento va más allá de estar a favor de su idoneidad o de su validez lógica. De hecho, sugiero que su valor puede ser entendido como resultado de su posición crucial dentro de lo que Heidegger llama la determinación de la esencia de la verdad. Comenzaré por explicar que, según Heidegger, la concepción moderna de la adaequatio corresponde a la Revolución Copernicana. Luego demostraré que esto permite interpretar el argumento ontológico de Anselmo como un argumento que abre la posibilidad al acontecimiento de la Revolución Copernicana. Continuaré poniendo en cuestión esta interpretación y sugeriré que hay una ambigüedad inherente en el argumento de Anselmo. Finalmente argumentaré que esta ambigüedad permite situarlo dentro de una posición crucial dentro del planteamiento de Heidegger de la determinación de la esencia de la verdad. Concluiré sugiriendo que la importancia del argumento de Anselmo reside en ser un punto de partida desde el cual una determinación de la esencia de la verdad iba a ser explícitamente asumida en una época posterior a la suya.
Aristóteles y el aborto: una mirada al principio de potencialidad
Authors: Leiva Matías
Published: May 2023

Aristóteles es uno de los autores que, directa o indirectamente, ha aportado más a la discusión contemporánea sobre diversos temas de bioética. El problema aborto destaca entre ellos por su actualidad y contingencia. En este artículo se propone un análisis del así llamado principio de potencialidad, argumento que ha sido utilizado tanto a favor como en contra de la defensa de la vida del nonato, abordando la lectura que se ha hecho de él, tanto de parte de la filosofía cristiana como de la escuela actualista inglesa. El objetivo del artículo es demostrar, siguiendo los principios de la ontología aristotélica, que la vida humana comienza en la fecundación.
Biografía, filosofía y catolicismo en la obra de Alasdair MacIntyre
Authors: Nontol Lucio
Published: May 2023

A partir de una de las realidades antropológicas fundamentales de la obra de MacIntyre, como es la confianza, en este escrito se desarrolla la idea de fe cristiana. La confianza como elemento esencial de la naturaleza humana permite dar el paso hacia la fe sobrenatural, ese paso supone un itinerario interlineal, que va desde la comprensión de sí mismo hasta una intelección nueva de toda la realidad. Supone un proceso de depuración de años de reflexión, confrontación y diversos análisis de los diferentes planteamientos filosóficos que el filósofo escocés entabló a lo largo de su vida como se verá en las siguientes páginas.
Corrigendum to: The Relation Between Stereochemistry and Biological Activity
of Platinum(II) Complexes Chelated with Chiral Diamine Ligands: An Intricate
Problem
Authors: Dufrasne F. , Galanski M.S.
Published: May 2023

An article was published in the journal "Current Pharmaceutical Design," Volume 13, No. 27, 2007, pp: 2781-2794 [1]. The first author is
requesting an alteration in the name.

Details of a correction are provided here.

The original name published was Markus Galanski. The request is to change the name to Mathea Sophia Galanski.

The original article can be found online at: https://www.eurekaselect.com/article/4836

We regret the error and apologize to readers.
A Non-targeted Metabolomics Reveals Therapeutical Effect and Mechanism of
Sanmiao Pill on Adjuvant-induced Arthritis Rats
Authors: Cao Dongdong , Yang Le , Gao Xin , Huang Danna , Zhan Xiaoning , Qiu Shi , Sun Hui , Yan Guangli , Wang Xijun
Published: May 2023

Background and Objective:

Rheumatoid arthritis (RA) is an increasingly serious disease worldwide
that can damage the joints and bones of sufferers. Sanmiao Pill (SMP), a classical traditional Chinese medicine
(TCM) prescription, has been used for effective treatments for RA in the clinic. To comprehensively illuminate
the therapeutic mechanism of SMP in the treatment of RA, the effects of SMP on biomarkers and metabolic
pathways in rats with adjuvant-induced arthritis (AIA) were examined.

Methods:

Sprague Dawley rats were randomly divided into two control (CC, Control) groups, two model (MM,
Model) groups, a methotrexate group (MTX, 7.6 mg/kg body weight per week), and two SMP groups (San-L,
28.7 mg/kg body weight per day and San-H, 57.4 mg/kg body weight per day). Rats' body weight, paw
swelling, arthritis scores, biochemical parameters, histopathology, and so on were used to evaluate the success
of the model and the therapeutic effects of SMP. The metabolic techniques were used to characterize the
metabolic profile and biomarkers of the serum and urine samples of rats to reveal the metabolic changes that occurred
after SMP treatment.

Results:

After 21 days of treatment, SMP improved weight gain, reduced the severity of paw swelling, lowered
the levels of biochemical indicators (CCP-Ab, IL-6, TNF-α, RF), decreased destruction of articular cartilage
and bone erosion, and protected the affected joints.Additionally, 17 and 19 potential biomarkers associated with
RA were identified in the serum and urine, respectively. SMP significantly reversed 14 potential biomarkers,
such as arachidonic acid, lysoPC(20:4(5Z,8Z,11Z,14Z)), L-tryptophan, 9-cis-Retinoic acid, hippuric acid, pyridoxine,
and pantothenic acid. These metabolites are associated with arachidonic acid metabolism, glycerophospholipid
catabolism, tryptophan metabolism, phenylalanine metabolism, vitamin B6 metabolism, etc.

Conclusion:

These results indicated that RA-related biomarkers reflected the metabolic profile of AIA rats.
Meanwhile, SMP could effectively treat RA mainly by reducing inflammation and regulating abnormal lipid
metabolic pathways and amino acid metabolisms. It showed that metabolomics could be used to analyze the
metabolic profiles involved in RA and reveal the mechanism of SMP treatment of RA.
siRNA Mediated Downregulation of RhoA Expression Reduces
Oxidative Induced Apoptosis in Retinal Ganglion Cells
Authors: Liu Qian , Liu Changgeng, , Lei Bo
Published: May 2023

Backgrounds:

Glaucoma is the second leading cause of blindness. Apoptosis of retinal ganglion cells (RGCs) is an important mechanism of glaucomatous optic injury. Rho kinase expression is significantly increased in apoptotic RGCs. This study aimed to investigate the role of RhoA, a Rho GTPase, on the survival of RGCs and further to explore its potential therapeutic applications.

Methods:

RGCs were treated with siRhoA for 24 hours in vitro. Knockdown of RhoA was confirmed with quantitative RT-PCR. Oxidative stress was induced by treating the RGCs with 200 μM of H2O2 for 1 hour, and apoptosis of RGCs was quantified with TUNEL assay in situ, and with flow cytometry. The mRNA expression levels of RhoA, Nogo receptor, caspase 3 and Bcl-2 were evaluated by quantitative RT-PCR, and the protein levels of RhoA, ROCK1, ROCK2, Nogo receptor, caspase 3 and Bcl-2 were evaluated by Western blot. We found siRhoA treatment efficiently downregulated the expression of RhoA in RGCs and protected against H2O2-induced injury in RGCs in vitro. Apoptosis of RGC cells under oxidative stress was quantified in situ using TUNEL assay and confirmed with flow cytometry (FCM).

Results:

With the knockdown of RhoA, the expression of ROCK1, ROCK2, Nogo Receptor, Casepase-3 were decreased, while the expression of Bcl-2 was increased in both mRNA and protein level. Our data indicated that siRhoA prevented H2O2-induced apoptosis in RGC cells by modulating the RhoA/ROCK pathway.

Conclusion:

The results suggested that siRhoA may exert potentially effective neuroprotection for RGCs by reducing injury.
An Extensive Review of MR Sensors with Design and Characteristic
Evaluation of Three-layered TMR Sensor
Authors: Gayathri Subramanian Vimala , Subbulekshmi Durairaj
Published: May 2023

The reliability and efficacy of sensor-based automated systems have improved due to
the proliferation of electric vehicles, renewable sources, and integrated systems in power industries
extensively. This has been accomplished by increasing the power density and decreasing the volume
of the system.

Background:

Mathematical estimation and comparative analysis of the physical factors result in
massive usage of operational matrices measured using sensors. Magnetic field sensors, used in
industries and biomedical applications, have a high level of precision in the evaluation of measurements.
In order to extract the measured parameters such as sensitivity, accuracy, operating cost,
the linear range of operation, and power utilisation, these sensors adhere to the physical constraints
during their nominal working conditions. The characteristics of the aforementioned sensors are
enumerated in detail in this article.

Objective:

This objective is highly focused on providing a comprehensive overview of classification
and the properties of Hall-Effect, anisotropic magnetoresistive (AMR), giant magnetoresistive
(GMR), and tunnelling magnetoresistive (TMR) sensors. The dissertation on its properties concludes
that TMR is more reliable and sensitive in variable operating conditions.

Methods:

The methods for selecting the sensors for an application are confined to voltage
fluctuations and sensitivity. A three-layered TMR sensor with two magnetic layers and an insulator
in between is proposed as a significant advancement compared to the literature. The micromagnetic
simulation is carried out at room temperature for a three-layered TMR made up of neodymium
alloy, magnesium oxide, and cobalt platinum alloy.

Conclusion:

Based on the studies executed, it is determined that TMR is more sensitive than both
conventional and MR sensors. The proposed schematic claims that the higher free layer thickness
offers maximum sensitivity with 77% negative magnetoresistance. The reduced coercivity of
1.9Oe is achieved in this combination at a specified temperature range.
Italian Guidelines for the Management of Prolactinomas
Authors: Cozzi Renato , Simona Auriemma Renata , De Menis Ernesto , Esposito Felice , Ferrante Emanuele , Iatì Giuseppe , Mazzatenta Diego , Poggi Maurizio , Rudà Roberta , Tortora Fabio , Cruciani Fabio , Mitrova Zuzana , Saulle Rosella , Vecchi Simona , Basile Michele , Cappabianca Paolo , Paoletta Agostino , Papini Enrico , Persichetti Agnese , Samperi Irene , Scoppola Alessandro , Bozzao Alessandro , Caputo Marco , Doglietto Francesco , Ferraù Francesco , Lania Andrea Gerardo , Laureti Stefano , Lello Stefano , Locatelli Davide , Maffei Pietro , Minniti Giuseppe , Peri Alessandro , Ruini Chiara , Settanni Fabio , Silvani Antonio , Veronese Nadia , Grimaldi Franco , Attanasio Roberto
Published: May 2023

Introduction:

This guideline (GL) is aimed at providing a reference for the management of prolactin (PRL)-secreting pituitary adenoma in adults. However, pregnancy is not considered.

Methods:

This GL has been developed following the methods described in the Manual of the Italian National Guideline System. For each question, the panel appointed by Associazione Medici Endocrinologi (AME) has identified potentially relevant outcomes, which have then been rated for their impact on therapeutic choices. Only outcomes classified as “critical” and “important” have been considered in the systematic review of evidence and only those classified as “critical” have been considered in the formulation of recommendations.

Results:

The present GL provides recommendations regarding the role of pharmacological and neurosurgical treatment in the management of prolactinomas. We recommend cabergoline (Cab) vs. bromocriptine (Br) as the first-choice pharmacological treatment to be employed at the minimal effective dose capable of achieving the regression of the clinical picture. We suggest that medication and surgery are offered as suitable alternative first-line treatments to patients with non-invasive PRL-secreting adenoma, regardless of size. We suggest Br as an alternative drug in patients who are intolerant to Cab and are not candidates for surgery. We recommend pituitary tumor resection in patients 1) without any significant neuro-ophthalmologic improvement within two weeks from the start of Cab, 2) who are resistant or do not tolerate Cab or other dopamine-agonist drugs (DA), 3) who escape from previous efficacy of DA, and 4) who are unwilling to undergo a chronic DA treatment. We recommend that patients with progressive disease notwithstanding previous tumor resection and ongoing DA should be managed by a multidisciplinary team with specific expertise in pituitary diseases using a multimodal approach that includes repeated surgery, radiotherapy, DA, and possibly, the use of temozolomide.

Conclusion:

The present GL is directed to endocrinologists, neurosurgeons, and gynecologists working in hospitals, in territorial services or private practice, and to general practitioners and patients.
On models of ground vibrations in strong earthquakes
Authors: Zainulabidova H. R. , Toturbieva U. Dz. , Jamaludinov A. M.
Published: May 2023

Objective. The purpose of these studies is to determine, on the basis of the developed models describing seismic impacts, the most acceptable for acceptance from the point of view of the accuracy of the description of the seismic oscillation both in the shape of the envelope and in duration and frequency characteristics.

Method. The use of empirical models in describing soil fluctuations as a random process has been considered in a number of papers. This paper presents the main simplifying assumptions used in this approach. The validity of empirical models and some difficulties encountered in modeling the oscillation process are investigated.

Result. A methodology for assessing the reliability of the proposed impact models is proposed. The proposed method takes into account the soil - geological characteristics, as well as spectral data of instrumental recordings of known earthquakes.

Conclusion. The seismic impact model, as well as the approximating modeling function, should be determined by the degree of responsibility of the building.