bluuebunny/crossref_metadata_2025 huggingface dataset:
Neuregulin-1 Regulates the Conversion of M1/M2 Microglia Phenotype via ErbB4-dependent Inhibition of the NF-κB Pathway
Authors: Ma Yuqi , Fan Peixia , Zhao Rui , Zhang Yinghua , Wang Xianwei , Cui Weigang
Published: December 2021

BackgroundThe inflammatory response caused by microglia in the central nervous system plays an important role in Alzheimer's disease. Neuregulin-1 (NRG1) is a member of the neuregulin family and has been demonstrated to have anti-inflammatory properties. The relationship between NRG1, microglia phenotype and neuroinflammation remains unclear.Materials and MethodsBV2 cells were used to examine the mechanism of NRG1 in regulating microglia polarization. Neuronal apoptosis, inflammatory factors TNF-α and iNOS, microglia polarization, ErbB4 and NF-κB p65 expression were assessed.ResultsWe found that exogenous NRG1 treatment or overexpression improved microglial activity and reduced the secretion of the inflammatory factors TNF-α and iNOS in vitro. The expression of Bax in SH-SY5Y neuron cells incubated with medium collected from the NRG1 treatment group decreased. Additionally, our study showed that NRG1 treatment reduced the levels of the M1 microglia markers CD120 and iNOS and increased the levels of the M2 microglia markers CD206 and Arg-1. Furthermore, we observed that NRG1 treatment attenuated Aβ-induced NF-κB activation and promoted the expression of p-ErbB4 and that knockdown of ErbB4 abrogated the effects of NRG1 on NF-κB, Bax levels and M2 microglial polarization. Conclusion﻿NRG1 inhibits the release of inflammatory factors in microglia and regulates the switching of the M1/M2 microglia phenotype, most likely via ErbB4-dependent inhibition of the NF-κB pathway.
Serum Uric Acid to HDL-Cholesterol Ratio is Associated with New-Onset NAFLD in Lean Chinese People with Normal Blood Lipid Levels: a Longitudinal Cohort Study
Authors: Zhu Wentao , Liang An , Shi Pei , Yuan Song , Zhu Ying , Fu Jiwei , Zheng Ting , Wen Zhilong , Wu Xiaoping
Published: December 2021

Background: Nonalcoholic fatty liver disease (NAFLD) is commonly occurred in the non-obese individuals. The serum uric acid (UA) to high-density lipoprotein cholesterol (HDL-c) ratio (UHR) is considered as a predictive factor of NAFLD. However, it is still difficult to confirm the correlation in lean Chinese people with normal blood lipid levels. It is aimed to analyze the correlation of UHR with NAFLD among lean Chinese population without dyslipidemia and compared UHR with other predictors in this study.Methods: 9838 lean people without NAFLD were included in a retrospective cohort study. NAFLD was diagnosed by liver ultrasound.Results: A total of 9,838 lean patients with normal blood lipid levels were included in the final study. During the five-year follow-up period, the overall prevalence of NAFLD was 8.7%. across the quintile 1, 2, 3, 4 and 5 of UHR, the prevalence of NAFLD among lean patients was increased from 2.4%, 5%, 7.9%, 10.3% to 17.8%. After adjustment for age, markers of liver and kidney function, gender and metabolic indicators, multivariate cox proportional hazard regression analysis demonstrated that the hazard ratio(HR) was 1.99(1.43-2.73) in highest UHR (quintile 5) compared with lowest UHR(quintile 1). The area under the curve(AUC) of UHR (0.690) was higher than in UA (0.666) and HDL-c (0.636), which showed that the predictive ability of the UHR to new-onset NAFLD was better than serum uric acid and HDL-c. Even within the normal range of UA and HDL-c levels, UHR was independently associated with NAFLD, and HR (95% confidence interva, 95%CI) for NAFLD in Quintile 5 of UHR was 6.74(4.32-10.53). Compared with other significant predictors, the AUC value of UHR(0.67) was similar to that of low-density lipoprotein cholesterol(LDL-c)/HDL-c ratio(0.68), non-high-density lipoprotein cholesterol (NHDL-c)/HDL-c ratio(0.68) and alanine aminotransferase (ALT)/ aspartate aminotransferase (AST) ratio(0.7), and superior to that of LDL-c (0.63), remnant cholesterol (RC,0.59), albumin(ALB)/alkaline phosphatase(ALP) ratio(0.61). The sensitivity of UHR (70.5%) was the highest among all indicators. In the subgroup of ALT, the AUC of UHR was 0.70, which was the highest among all predictors in subjects with ALT< 40. For subjects with elevated ALT levels (ALT > 40 U/L), there was no statistical significance among RC (P=0.441), ALB/ALP (P=0.419) and ALT/AST(P=0.159). In contrast, UHR's performance in predicting NAFLD was meaningful and reliable (AUC=0.61, p<0.001).Conclusions: UHR serve as an inexpensive and reliable predictor of NAFLD in lean Chinese people with normal blood lipid levels. It can be used to identify people at high risk of NAFLD.
Time-Independent Forecast Model For Large Crustal Earthquakes in Southwest Japan Using GNSS Data
Authors: Nishimura Takuya
Published: December 2021

In this study, we developed a regional likelihood model for crustal earthquakes using geodetic strain rate data from southwest Japan. First, smoothed strain rate distributions were estimated from continuous GNSS measurements. Second, we removed the elastic strain rate attributed to interplate coupling on the subducting plate boundary, including the observed strain rate, under the assumption that it is not attributed to permanent loading on crustal faults. We then converted the geodetic strain rates to seismic moment rates and calculated the 30-year probability for M ≥ 6 earthquakes in 0.2 × 0.2° cells, using a truncated Gutenberg–Richter law and time-independent Poisson process. Likelihood models developed using different conversion equations, seismogenic thicknesses, and rigidities were validated using the epicenters and moment distribution of historical earthquakes. The average seismic moment rate of crustal earthquakes recorded during 1583–2020 was only 13–20 % of the seismic moment rate converted from the geodetic data, which suggests that the observed geodetic strain rate includes considerable inelastic strain. Therefore, we introduced an empirical coefficient to calibrate the moment rate converted from geodetic data with the moment rate of the earthquakes. Several statistical scores and the Molchan diagram showed that all models could predict real earthquakes better than the reference model, in which earthquakes occur uniformly in space. Models using principal horizontal strain rates exhibited better predictive skill than those using the maximum horizontal shear strain rate. There was no significant difference in the predictive skill between uniform and variable distributions for seismogenic thickness and rigidity. The preferred models suggested high 30-year-probability in the Niigata–Kobe Tectonic Zone and central Kyushu, exceeding 1% in more than half of the analyzed region. Model predictive skill was also verified by a prospective test using earthquakes recorded during 2010–2020. This study suggests that the proposed forecast model based on geodetic data can improve the regional likelihood model for crustal earthquakes in Japan in combination with other forecast models based on active faults and seismicity.
The Effect of Acellular Dermal Matrix on the Success of Primary Palatoplasty With Intravelar Veloplasty
Authors: Abdali Hossein , Hoghooghi Mohammad Ali , Fattahpour Shirin , Derakhshandeh Fatemeh , Mohtashampour Farnoosh , Ghanei Amin
Published: December 2021

BackgroundAcellular Dermal Matrix graft is usually used to repair fistulas following a cleft palate and has had positive results. But its use for primary palatoplasty has been less studied. Our aim was to compare the usefulness of using Acellular Dermal Matrix transplantation for primary palatoplasty with intravelar veloplasty in contrast to its lack of useMaterials and methodsA total of 72 children (6 months to 6 years old) with cleft palate were included in the study. The case-control prospective observations were conducted. A group underwent primary palatoplasty with intravelar veloplasty using Acellular Dermal Matrix and the control group had the same surgery without using Acellular Dermal Matrix. Patients were monitored for fistula formation, post-operative infection, and ulcers.ResultsNo post-surgical infection and wound opening was seen in any group. In the recipients of Acellular Dermal Matrix and control group three and six fistula was reported in which patients had soft and hard palate involvement and the cleft with length greater than 15 mm.ConclusionsConsidering the double incidence of fistulas in the control group compared to the ADM recipient, it seems that the use of ADM can be effective in reducing the incidence of fistulas. Since fistula is one of the complications of primary palatoplasty surgery and leads to secondary surgeries, the use of ADM can be helpful.
Neural Networks Implicated in Autobiographical Memory Training
Authors: Cȋrneci Dragoş , Onu Mihaela , Papasteri Claudiu C. , Georgescu Dana , Poalelungi Catalina , Sofonea Alexandra , Puşcaşu Nicoleta , Tanase Dumitru , Rădeanu Teofila , Toader Maria-Yaelle , Dogaru Andreea L. , Podină Ioana R. , Berceanu Alexandru I. , Carcea Ioana
Published: December 2021

Training of autobiographical memory has been proposed as intervention to improve cognitive functions. The neural substrates for such improvements are poorly understood. Several brain networks have been previously linked to autobiographical recollections, including the default mode network (DMN) and the sensorimotor network. Here we tested the hypothesis that different neural networks support distinct aspects of memory improvement in response to training on a group of 59 subjects. We found that memory training using olfactory cues increases resting-state intra-network DMN connectivity, and this associates with improved recollection of cue-specific memories. On the contrary, training decreased resting-state connectivity within the sensorimotor network, a decrease that correlated with improved ability for voluntary recall. Moreover, only the decrease in sensorimotor connectivity associated with the training-induced decrease in the TNFα factor, an immune modulation previously linked to improved cognitive performance. We identified functional and biochemical factors that associate with distinct memory processes improved by autobiographical training. Pathways which connect autobiographical memory to both high level cognition and somatic physiology are discussed.
Epidemiology and Clinical Features of Birt-Hogg-Dubé Syndrome: A Nationwide Population-Based Study in South Korea
Authors: Park Hyung Jun , Kim Ye-Jee , Kim Min-Ju , Kim Hocheol
Published: December 2021

Background

Birt–Hogg–Dubé (BHD) syndrome is an ultrarare lung disease with unclear prevalence and incidence. Our study aimed to identify the epidemiological and clinical features of BHD syndrome by using nationwide claims data from the Korean Health Insurance Review and Assessment service.
Results

We found 26 patients with BHD syndrome from 2017 to 2019. The prevalence of BHD syndrome was 5.67 per 107 population, with no peak age. Among incidence cases, the median age of diagnosis was 51 years, with slightly more females than males (n = 15, 57.7%). Over half of the patients (n = 14, 53.8%) experienced pneumothorax, and 10 (38.5%) developed malignant neoplasm within the clinical course.
Conclusions

The prevalence of BHD syndrome in Korea is extremely low. However, affected patients manifest several comorbidities, including malignant neoplasm and repetitive pneumothorax.
Navigating Communication Between Western Medicine And Traditional Chinese Medicine: A Case Study of Cancer Patients In Hong Kong
Authors: Pun Jack , Wong Wendy
Published: December 2021

Background: Traditional Chinese Medicine (TCM) is a growing phenomenon around the world. However, despite its historical role in Chinese society, there has been limited research exploring the nature of communication around cancer patients who receive TCM care in additional to conventional medicine. If TCM practitioners with adequate knowledge in understanding the needs and communication issues around patients with cancer, particularly those who simultaneously receive conventional medicine, it will lead to a better quality of care and result in better clinical outcomes such as high patient satisfaction and compliance with treatments. Objectives: To fill in this gap, this study aims to explore the nature of the communication amongst cancer patients in Hong Kong who receive TCM treatment in addition to conventional medicine. Methods: Twenty patients, 5 oncologists and 5 TCM practitioners were invited to conduct in-depth interviews to elicit their views towards their TCM treatment. A qualitative approach called Interpretative phenomenological analysis (IPA) is adopted. Results: Based on the themes that emerged from the interview transcripts, we outline the priorities of communication when dealing with cancer patients who receive both TCM and conventional medicine. A framework was developed to assist training TCM practitioners to better integrate their patients' conventional medical history when delivering patient care. Conclusion: The findings of this study can shed light to inform priorities in communication when caring for patients who opt for TCM care in addition to conventional treatments, and to provide useful information for developing future clinical research of providing integrated approach between TCM and conventional medicine in treating cancer patients.
Coherent Photonic Terahertz Transmitters Compatible with Direct Comb Modulation
Authors: Gonzalez-Guerrero Luis , Carpintero Guillermo
Published: December 2021

We present a novel approach to coherent photonic THz systems supporting complex modulation. The proposed scheme uses a single optical path avoiding the problems of current implementations, which include: phase decorrelation, 3-dB power loss, and polarization and power matching circuits. More importantly, we show that our novel approach is compatible with direct modulation of the output of an optical frequency comb (i.e., not requiring the demultiplexing of two tones from the comb), further simplifying the system and enabling an increase in the transmitted RF power for a fixed average optical power injected into the photodiode (PD).
An Artificial Intelligence Pipeline for Diagnosing Hepatocellular Carcinoma Patients with Bile Duct Tumor Thrombus
Authors: Liu Jinming , Wu Jiayi , Liu Anran , Bai Yannan , Zhang Hong , Yan Maolin
Published: December 2021

Background and purpose: Preoperative diagnosis of bile duct tumor thrombus (BDTT) is clinically important as the surgical prognosis of hepatocellular carcinoma (HCC) patients with BDTT is significantly different from that of patients without BDTT. The preoperative diagnosis of BDTT is usually based on identification of dilated bile ducts (DBDs) on medical images (eg., CT and MRI images). However, it is easy for doctors to ignore DBDs when reporting the imaging scan result, leading to a high misdiagnosis rate in practice. The aim of the present study was to develop an artificial intelligence (AI) pipeline for diagnosing HCC patients with BDTT using medical images. Methods: The proposed AI pipeline included two stages. First, the object detection neural network Faster R-CNN was adopted to identify DBDs; then, an HCC patient was diagnosed to have BDTT if the proportion of images with at least one identified DBD exceeds some threshold value. Four-fold cross validation was used to evaluate the performance of the proposed AI pipeline. Results: The proposed AI pipeline was applied on a real dataset consisting of CT images collected from 34 HCC patients (16 with BDTT and 18 without BDTT). The average true positive rate for identifying DBDs per patient was 0.92, while the patient-level true positive rate for diagnosing BDTT was 0.94. The AUC value of patient-level diagnosis of BDTT was 0.92 (95% CI: 0.83, 1.00), compared with 0.71 (95% CI: 0.52, 0.89) by random forest. Conclusions: This study first proposes an AI pipeline to identify DBDs and diagnose BDTT, and the high accuracies demonstrate that it is successful in the diagnosis of BDTT.
Do Canadians Support Tailored And Targeted Public Health Programs? A Discrete Choice Experiment
Authors: Card Kiffer G. , Adshade Marina , Hogg Robert S. , Jollimore Jody , Lachowsky Nathan J.
Published: December 2021

Background. We aimed to assess public support of tailored and targeted public health interventions for various marginalized communities. Methods. We conducted a discrete choice experiment using a web-based survey advertised to Facebook and Instagram users living in Canada, aged >16. Participants were asked to choose between funding two hypothetical public health programs. Each program was described by its purpose; expected increase in life expectancy; and target group. Demographically-weighted generalized linear mixed-effects models were constructed to identify program factors associated with program selection.Results. 23,889 exercises were completed by 3,054 participants. Selected programs were less likely to focus on prevention (vs. treatment). For each 1-year increase in the marginal years of life gained, there was a 15% increase in the odds of a program being selected. Interventions tailored to marginalized communities or targeting stigmatized health conditions were less likely to be selected compared with interventions targeted to the general population or targeting chronic health conditions. Noteworthy exceptions included an increased preference for interventions aligning with the perceived needs of marginalized communities (e.g. HIV and men who have sex with men). Conclusions. Stigmatizing perceptions of health conditions and key populations likely influence public health programming preferences of Canadians. Informational campaigns highlighting disparities experienced by marginalized populations may improve support for targeted and tailored interventions.
Environmental risks and power plant suspensions
Authors: Lu Yangsiyu , Zhou Xiaoyan , Simmons Blake
Published: December 2021

Power sector investment is crucial to accelerate a sustainable energy transition, but not all investments are successful. To shed light on investment trends, we examine 1393 Chinese overseas electric power projects spanned around 78 countries over the past two decades. We identify 5% have been cancelled or delayed, with coal and hydro projects having much higher failure rates than solar and wind projects. We find the suspension is associated with technology-specific, georeferenced environmental risks. Coal projects located in more densely populated areas where more people are exposed to air pollutants, in countries with more fatalities from extreme weather events, and in places with environmental protests, are more likely to be suspended. Additionally, hydro projects closer to protected areas have a higher suspension rate. Our results suggest that restraining from investing in environmentally risky projects helps mitigate environmental damages and prevent financial losses due to cancellation and postponement.
The effect of stem cells in repairing growth plate injury: a systematic review and meta-analysis
Authors: Xu Xiao-long , Lu Sheng-jun , Pei Hong , Chen Shun-guang , Liao Quan-ming
Published: December 2021

Background: Multiple studies have focused on stem cell-based therapies for growth plate injury.However, the results are not consistent.Objectives: This systematic review and meta-analysis were performed to evaluate the effects of stem cells on growth plate healing.Methods: A detailed search of relevant studies was conducted in three databases including Pub med, Cochrane library, and Embase databases, using the following keywords: “growth plate” or “physis” AND “stem cell” from inception to November 10, 2021. The standard mean difference (SMD) and 95% confidence interval (CI) for each individual study were extracted from the original studies based on relevant data and pooled to obtain integrated estimates using random effects modeling.Results: A total of 6 studies were identified. The results demonstrated that the angular deformity in the stem cell group was significantly lower than that in the control group at 4, 8,12 and 16weeks. The length discrepancy represented the degree of shortening deformity. In the stem cell group, the shortening deformity was milder than that of the control group at 16weeks. Meanwhile, at 16 weeks after surgery, the higher histologic scores in the stem cell group indicated that stem cell can significantly improve the repair quality of growth plate.Conclusions: This systematic review and meta-analysis confirmed that stem cell improved the rehabilitation of growth plate injury. However, larger-scale studies are needed to further support these findings.
Metformin extended-release versus metformin immediate-release for adults with type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials
Authors: Abrilla Aedrian A. , Pajes A. Nico Nahar I. , Jimeno Cecilia A.
Published: December 2021

This systematic review aimed to compare the efficacy and tolerability of metformin extended-release (MXR) and the conventional metformin immediate-release (MIR) in adults with type 2 diabetes mellitus (T2DM). PubMed, the Cochrane Library and ClinicalTrials.gov, from database inception to 15 October 2020, and other sources were searched for randomized controlled trials (RCTs) that compared equal daily doses of MXR and MIR in adults with T2DM. Random-effects model meta-analysis was performed to obtain pooled mean difference (MD) of change from baseline for continuous outcomes (glycemic and serum lipid control and anthropometrics) and risk ratio (RR) for dichotomous outcomes (gastrointestinal and serious adverse events). Statistical analysis involving 9 published RCTs with 2609 subjects revealed that MIR was associated with better HbA1c lowering (MD 0.09% [95% confidence interval, 0.02%, 0.17%]) and serum lipid control except LDL-C lowering, while MXR reduced only the cumulative incidence of dyspepsia (RR 0.58 [0.34, 0.98]). MXR and MIR were similar in all other considered outcomes. The use of MXR over MIR among adults with T2DM was associated with statistically worse but likely clinically insignificant HbA1c lowering, similar plasma glucose lowering, and minimal improvement of metformin intolerance. This information may guide patient-physician discussions in choosing between the two formulations.
Nanoscale Infrared Spectroscopy Reveals Nanoplastics at 5000 m Depth in the South Atlantic Ocean
Authors: Weckhuysen Bert , Have Iris ten , Meirer Florian , Oord Ramon , Zettler Erik , Sebille Erik Van , Amaral-Zettler Linda
Published: December 2021

Millimeter- and micrometer-sized plastics are well-documented in aquatic ecosystems, but little is known about sub-micrometer particles because conventional analytical techniques lack sufficient spatial resolution or the spectroscopic means to unambiguously identify individual nanometer-sized plastic particles. We combined the spatial resolution of atomic force microscopy with chemical information from infrared spectroscopy to detect, identify, and count nanoplastics down to 20 nm in diameter in samples from different depths in the South Atlantic Ocean. We present evidence for the presence of polyethylene terephthalate (PET) nanoplastics in different states of degradation at 5000 m. Using lab-based ageing of PET, we demonstrate that nanoplastics can form even without light or interaction with the plastisphere, and that macroscopic PET items are a plausible source of PET nanoplastics in the ocean.
First Isolation of Leptospira Borgpetersenii Serovar Hardjobovis in Guanacos (Lama Guanicoe) in South America
Authors: Brihuega Bibiana , Saraullo Vanina , Martinez Mara , Watanabe Olivia , Hamer Micaela , Loffler Sylvia Grune
Published: December 2021

Background

Leptospirosis is the most widespread zoonotic disease in the world. It is caused by pathogenic spirochetes of the genus Leptospira spp. and is maintained in nature through chronic renal infection of carrier animals, being rodents and other small mammals the main reservoirs. This bacterial genus is highly heterogeneous and divided into three clades (pathogenic, saprophyte and intermediate). Presence of pathogenic strains in wildlife populations is essential to monitor the epidemiological status of this disease worldwide.
Methods

In this study, we characterize an isolated strain of a Guanaco (Lama guanicoe) using Multiple Locus Variable number tandem repeats Analysis (MLVA) (Variable Number Tandem Repeats-VNTRs: 4, 7, 10, Lb4 and Lb5). To confirm the identity of the isolated strain, partial 16S rRNA sequencing was carried out. Phylogeny was constructed using Neighbor- joining.
Results

The pathogenic leptospiral strain isolated from Llama guanicoe had the genetic profile identical to L. borgpetersenii serovar Hardjobovis reference strain Sponselee.
Conclusions

To the best of our knowledge, this is the first isolation and genetic characterization of a pathogenic leptospiral strain in Guanacos in South America.
Talent Retention: A Mediator of the Relationship Between Talent Management Strategies and Succession Planning
Authors: Poonam Jindal  , Mohsin Shaikh
Published: December 2021

Succession planning is becoming a focus point for discussion in business world as very few organisations are prepared with their successors for occupying the position as and when it is needed. With special reference to Indian pharmaceutical companies, where talent is critical and rare in nature, this becomes a more crucial requirement. This paper, by integrating theory of Internal Labour Market (ILM), deals with the relationship among talent identification (TID), talent development (TD), talent retention (TR), and succession planning in Indian pharmaceutical companies. A survey method was used for collecting the response of senior level managers of pharmaceutical companies located in Hyderabad, India, and the hypothetical model and structural relationships were tested via structural equation modelling (SEM). The findings of the research present that TR plays a role of mediator in the relationship of TID, TD and succession planning in organisations. This study helps pharmaceutical companies to be future ready for succession planning by using their regular talent management strategies skilfully. This study beautifully develops an empirical relationship between TID, TD, and succession planning with the mediating effect of TR. Research also brings out the theoretical importance of ILM theory. This, as per best of researchers’ knowledge, was not presented in earlier research on talent management or on succession planning.
Competitiveness of International Airports Production Infrastructure in Global Air Transportation Market: Comprehensive Situational Model
Authors: Kateryna Sydorenko  , Oleksandr Sydorenko  , Olena Lozhachevska  , Olha Pashchenko
Published: December 2021

The article summarises the essence of airport infrastructure and explores the roles of production airport infrastructure in the world air transport system. It is noted that airport infrastructure is a complex dynamic subsystem of global production infrastructure of the world economy and is aimed at providing competitive air transportation services. It is substantiated that the competitive production infrastructure of international airports is a key element of the economic development of countries in the world economy. In particular, reliable airport infrastructure is one of the key factors in increasing the countries capacity for real economic growth, both in the short and long term. Generalised and systematic views of scientists have led to the conclusion that today there is no single universally accepted methodology that would comprehensively explore and evaluate the competitiveness of the airport's infrasystem, and identify its strengths and weaknesses. Therefore, this study aims to develop and substantiate the methodology for assessing the level of competitiveness of the production infrastructure of international airports in the global aviation market. The proposed methodological approach makes it possible to provide a practical assessment of the competitiveness of the airport's infrasystem, taking into account the wide range of indicators, converted through a fuzzy linguistic approach. It should be noted that the main purpose of creating and implementing an evaluation system is to facilitate the successful implementation of the competitiveness management functions of the production infrastructure of international airports in the global aviation market. The developed model may be used by international aviation organisations and governments in the process of strategic planning of the air transport development.
THE SIGNIFICANCE OF JOB INVOLVEMENT, ANDEMPLOYEE ENGAGEMENT IN INCREASING ORGANIZATIONAL EFFECTIVENESS
Authors:   Lecturer, Department of Mathematics, STKIP Kusuma Negara Jakarta, Indonesia., Nurfalah Dade , Tsalsa Sofiawati Esmi ,   Lecturer, Department of Primary School Teacher Education, STKIP BinaMutiara Sukabumi, Indonesia., Natalia Sartono Lidya ,   Lecturer, Department of Informatics Engineering, UniversitasIndraprasta PGRI Jakarta, Indonesia., Supendi Moh. ,   Lecturer, Department of Economic Education,UniversitasMuhammadiyah Prof. Dr., Hamka (UHAMKA) Jakarta, Indonesia., Narsih Dwi ,   Lecturer, Department of Economic Education, UniversitasIndraprasta PGRI Jakarta, Indonesia.
Published: December 2021

Employee job involvement is critical in an organization, especially when it comes to increasing organizational effectiveness and improving organizational performance. Similarly, employee engagement involves a sense of emotional involvement from within the employee, which ultimately increases the organizations effectiveness. The objective of the research is to obtain information about the influence of job involvement and employee engagement on organizational effectiveness. In this study, the researcher attempt to study how this job involvement influences organizational effectiveness, how employee engagement influences organizational effectiveness, and how this job Involvement has indirect influence is mediated by employee engagement. The research was conducted on all employees of the Human Resource Development Agency of Indonesias Tourism Ministry of Indonesia by using a survey method with path analysis applied in testing the hypothesis. The number 86 employees as the sample was selected by using the Slovin formula. From the results structural equation modeling the researcher finds a significant influence of job involvement on organizational effectiveness, and significant influence of employee engagement on organizational effectiveness, and also the indirect influence of job Involvement on organizational effectiveness mediated by employee engagement of the employee of Human Resource Development Agency of Indonesias Tourism Ministry of Indonesia.
RETROSPECTIVE ANALYSIS OF FUNDUS CHANGES IN POST COVID RHINO ORBITAL CEREBRAL MUCORMYCOSIS - A CASE SERIES
Authors:   Professor and HOD, Dept of Ophthalmology, Kurnool Medical College., Revathy M.S K. , Kasturi Bai M.S N. ,   Assistant Professor, Dept of Ophthalmology, Kurnool Medical College., Krishna Priya Rambe ,   Junior Resident, Dept of Ophthalmology, Kurnool Medical College.
Published: December 2021

Aim:To study the fundus changes in post COVID- Rhino-orbital-cerebral mucormycosis. Methods: The study was done by collecting data from 30 cases of ROCM admitted in GGH, Kurnool. Detailed history was taken along with systemic ,ENT, ophthalmic and neurological examination and all necessary investigations were done including contrast enhanced MRI. Treatment was started with systemic and retrobulbar amphotericin-B injections. Fundus pictures were taken. Results: All of them had history of infection with covid-19 dated about 3-5 weeks back. Among them 18 had corticosteroid administration, 12 had oxygen with nasal prongs/mask, 2 had high flow/non-invasive ventilation. All of them were diabetics and 21 were hypertensives.Most of them had orbital/facial pain & edema, headache, 24 patients had proptosis, 16 had ptosis, 20 had ocular movement restriction,18 had loss of vision. In Contrast Enhanced MRI scan, 28 cases showed diffuse PNS involvement,4 had medial orbital involvement, 8 had diffuse orbital involvement,18 had involvement of orbital apex, 6 had CNS involvement. Fundus examination revealed optic atrophy in 15 cases, 5 had CRAO and 3 had CRVO,8 had diabetic retinopathy,4 had hypertensive retinopathy, others had no significant abnormality. Conclusion: Mucormycosis is a rapidly progressive angioinvasive fungal infection which has been on rise in India with the 2nd wave of COVID-19. Early diagnosis and management are essential to halt the spread of infection and prevent diminution of vision and therefore, further improve the visual outcome and overall prognosis of the patient.
ROLE OF NUTRITION IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE: A REVIEW
Authors:   Assistant Professor,Department of respiratory Medicine,Chettinad Hospital and Research Institute,Kelambakkam., Vennilavan Naveen , a Gayathri ,   Student,B.sc Respiratory Care ,Department of respiratory Medicine,Chettinad Hospital and Research Institute,Kelambakkam., Ganga Nisha ,   Senior Resident,Department of respiratory Medicine,Chettinad Hospital and Research Institute,Kelambakkam., Narashiman Meenakshi ,   Professor,Department of respiratory Medicine,Chettinad Hospital and Research Institute,Kelambakkam.
Published: December 2021

Chronic obstructive pulmonary disease which mainly affects lung due to the inflammation in the airway and alveoli over a long period of time causing excessive mucus production and airway trapping. The majority of COPD patients are affected with nutrition depletion due to their systemic inflammation and multiple other factors. Malnutrition in Chronic Obstructive Pulmonary Disease affects the lung function, tolerance in exercise, and Quality Of Life. The early evaluation and treatment of malnutrition in COPD might aid in improving the morbidity and mortality.
A RARE CASE OF HARLEQUIN ICHTHYOSIS SUCCESSFULLY TREATED WITH ACITRETIN: A CASE REPORT AND LITERATURE REVIEW
Authors:   Intern, UQU, Makkah, KSA. MBBS (Intern)., Abdulghani Taj Mashael , Abdulaziz Alharbi Imtinan ,   Intern, UQU, Makkah, KSA. MBBS (Intern)., Walid Azzhary Lein ,   Intern, UQU, Makkah, KSA. MBBS (Intern)., Ghazi Alhazmi Renad ,   Intern, UQU, Makkah, KSA. MBBS (Intern)., Hussain Habibullah Taha ,   Consultant Dermatology, Physician, Alnoor Specialist Hospital â€Makkah, KSA., Samir Mohammed Salma ,   Consulatnt Dermatology, Physician, Al Azhar University, Al-Zahraa Hospital, Cairo, Egypt.
Published: December 2021

Harlequin Ichthyosis is the most serious congenital keratinization disorder. When the children are born, they are enveloped in thick horn armor. They are thick yellow horn plates that tear deeply when they dry out. In the most severe form, the children often die in the first few weeks of life. But there are also many milder courses, whereby there are obviously flowing transitions from collodion baby to harlequin ichthyosis. The skin condition later corresponds to that of a child with severe congenital ichthyosis (ARCI). Similar to the collodion baby, cases of harlequin ichthyosis should initially be cared for in the intensive care unit for newborns and require interdisciplinary therapy. Harlequin ichthyosis is caused by very special mutations in the ABCA12 gene. These mutations also have an impact on survival. If homozygous mutations are present, the prospects are worse than if the parents have heterozygous mutations. Homozygous mutations are often present when the parents are consanguineous.
JOB SATISFACTION OF THE EMPLOYEESAT RED STARUNIVERSITY IN VIETNAM
Authors:   VNU, University of Economics and Business., Thi Phi Nga Nguyen , Trieu Khoi Tran ,   VNU, University of Economics and Business.
Published: December 2021

The current paper aims to analyze the effect of thesix factors on the employeessatisfaction with their jobs atSao Do(Red Star) University in the North of Vietnam, which include: job characteristics, income and welfair, training for promotion, colleague, superior, working condition. The individual factor is also investigated in this study. The results of the research show that all the six factors have positive relation to the employees satisfaction with jobs while the individual factor (age, gender, educational/skill level) has no different effect to the employees satisfaction with job. Quantitative research methodology was applied for the research and some suggestions for Sao Do(Red Star)University was also proposed to increase their employees satisfaction with their jobs.
Tras la ruta del Café Nasa. Técnicas de organización en Tierradentro, Colombia
Authors: Cabrera Bravo Janeth A.
Published: December 2021

Este texto es parte una investigación etnográfica centrada en el cultivo, transformación y comercialización del café, para observar la relación entre los productores y comercializadores de la región de Tierradentro (Colombia). Todo es parte de los procesos en que las comunidades indígenas y campesinas desarrollan sus propias nociones de vida, familia, economía y territorio. En este sentido se analiza las formas de organización que intervienen de manera relacional con el ambiente y, así, construyen continuamente formas de existencia, comunicación e intercambio en el contexto inicialmente señalado. El objetivo de entender y analizar la agricultura, el trabajo manual y las estrategias de alianzas comerciales, como formas creativas por solventar la vida en comunidad en contextos interétnicos. Los modos de producción asociados a la economía cafetera perfilan múltiples formas de coexistencia entre sujetos, entornos y prácticas, en los lugares de la geografía tropical donde la planta se adapta, lugares que no son los mismos donde el producto se vende a buenos precios, por el reconocimiento de la trazabilidad del origen y el perfil de taza, entre otras valoraciones. Este artículo destaca las experiencias de caficultores del pueblo nasa en relación con su historia de fortalecimiento social y defensa territorial, así como con los procesos tecnológicos de carácter heterogéneo. En este sentido, este texto, narra varios puntos de vista, que son parte de una trama entre personas, cosas, ambientes y técnicas, que confluyen en la relación continua de creación de un producto como el café especial de Tierradentro.
Representações sociais do trabalho e da qualidade de vida para servidores de bibliotecas universitárias
Authors: Tinoco Ana Cristina Cavalcanti
Published: December 2021

As bibliotecas acadêmicas brasileiras se multiplicaram e modernizaram a partir das avaliações obrigatórias do Sistema Federal de Educação Superior. Na Universidade Federal do Rio Grande do Norte, o Sistema é composto por 22 bibliotecas. Fatores como gestão tradicional, crenças e valores divergentes, tarefas repetitivas, entediantes, ou desafiadoras, que demandam tecnologias atuais e o funcionamento extenso das bibliotecas são objetos de tensões e conflitos que parecem atingir o trabalho e outras dimensões da vida. As questões da pesquisa se voltaram para compreensões consensuais sobre trabalho e qualidade de vida (QV) dos servidores dessas bibliotecas, para identificar possíveis aproximações entre os fenômenos.
Quando os museus entram no ambiente digital: atuação e usuários
Authors: Bezerra Lehi Aguiar , Andrade Elisângela Moura de
Published: December 2021

Os avanços tecnológicos, das últimas décadas, ampliaram as possibilidades de disseminação da informação através da diversificação dos suportes disponíveis, principalmente no meio eletrônico.  Nesse contexto, não apenas as informações são alocadas nos novos espaços eletrônicos, mas as instituições começam a ocupar e a se adaptar a esses ambientes, com a finalidade de encontrar novos espaços de atuação e de potencializar seus serviços e produtos com as ferramentas da web,  atraindo, dessa forma, novos usuários.
Implantação de Repositório Digital para disseminação de informação científica: estudo de caso do Instituto Evandro Chagas
Authors: Silva Neta Clarice Pereira Barros da , Rocha Paulo Santana
Published: December 2021

Aborda o processo de implantação do repositório digital por meio da migração dos dados bibliográficos da produção científica contidos na Biblioteca Virtual Instituto Evandro Chagas para o sistema DSpace. Apresenta as etapas de desenvolvimento do software autônomo que viabilizou o processo de migração do aplicativo LILBDI-Web para a plataforma do sistema DSpace, bem como as estratégias utilizadas no processo, destacando a importância que a criação do repositório irá trazer para Região Norte e para a pesquisa em saúde publica e, desta maneira, introduzir o Instituto Evandro Chagas no rol dos principais repositórios de pesquisas nacionais e internacionais.
As cores do acesso aberto à comunicação científica
Authors: Cunha Jacqueline de Araújo
Published: December 2021

Apresenta as políticas editoriais de revistas cientificas no que concerne às questões relativas ao acesso aberto. Para tanto, utiliza como base uma experiência estrangeira denominada SHERPA/RoMEO e outra brasileira, coordenada pelo Instituto Brasileiro de Informação em Ciência e Tecnologia, o Diadorim. Ressalta que as políticas se apresentam com diferentes permissões e restrições relativas à disponibilização de artigos científicos em repositórios, as quais são classificadas em quatro cores: azul, verde, amarela e branca. Ressalta a importância desse tipo de serviço para os repositórios no intuito de assessorar pesquisadores e instituições na gestão de repositórios e políticas de comunicação científica.
O Centro de Documentação do Museu Câmara Cascudo e o Sistema de Bibliotecas da Universidade Federal do Rio Grande do Norte:
Authors: Silva Igor Oliveira , Tanus Gabrielle Francinne
Published: December 2021

Resumo: Apresenta a trajetória do Museu Câmara Cascudo e a potencialidade do acervo documental e bibliográfico, que compõe o centro de documentação da instituição, e que serve como fonte para o desenvolvimento de diversas pesquisas. As pesquisas de extensão que envolvem o Museu também foram levantadas a fim de mostrar o enlace com a comunidade e a efetivação da tríade da Universidade – ensino, pesquisa, e extensão. Evidencia-se a importância do centro de documentação do Museu Câmara Cascudo em integrar o Sistema de Biblioteca Universitária da Universidade Federal do Rio Grande do Norte (UFRN), tendo em vista que o museu está vinculado a esta instituição de ensino superior. A partir da entrevista com os gestores das instituições, do Museu e da Biblioteca Universitária, como também com o servidor arquivista, buscou-se expor e compreender o porquê da não efetivação do museu dentro do Sistema de Bibliotecas. Ademais destaca-se a importância e as consequências da ausência do bibliotecário em um dos principais museus do estado do Rio Grande do Norte.

Palavras-chaves: Museu Câmara Cascudo. Centro de Documento. Sistema de Bibliotecas. Universidade Federal do Rio Grande do Norte.
A inovação pedagógica do PFLEX na UFMG
Authors: Carsalade Flávio
Published: December 2021

O curso de graduação em Arquitetura e Urbanismo da Universidade Federal de Minas Gerais criou, em 2011, uma inovação pedagógicano ensino de projeto arquitetônico representada por módulos flexibilizados sem posição fixa na grade curricular e de livre escolhado aluno. O presente trabalho discute os pontos positivos e negativos da experiência e relaciona-a a caso concreto ligado ao tema deprojeto de intervenção em bem cultural.
ARQUITETURA E SÍTIO: TRÊS MUSEUS DE ARTE CONTEMPORÂNEA DE ÁLVARO SIZA
Authors: Nóbrega Lívia
Published: December 2021

Este artigo explora a relação entre sítio e arquitetura, analisando três edifícios de museus de arte contemporânea, a partir das reflexões do crítico e teórico norte-americano David Leatherbarrow (2000, 2004). Os edifícios são projetos do arquiteto português Álvaro Siza: o Centro Galego de Arte Contemporânea (Santiago de Compostela, Espanha, 1988-93), o Museu de Arte Contemporânea da Fundação de Serralves (Porto, Portugal, 1991-99) e a sede da Fundação Iberê Camargo (Porto Alegre, Brasil, 2000-08). Distintos em localização e semelhantes em tipologia, os edifícios são entendidos por meio de cinco estratégias projetuais de relacionamento com o sítio.
DIAGRAMAS ARQUITETÔNICOS E ESTRATÉGIAS PROJETUAIS: reflexões sobre composição e retórica
Authors: Sobreira Fabiano José Arcadio
Published: December 2021

Este artigo tem como objetivo apresentar reflexões preliminares sobre o uso de recursos diagramáticos na arquitetura contemporânea, a partir de duas abordagens complementares: (1) retórica propositiva e (2) análise da composição. A primeira questão está relacionada ao uso de recursos gráficos diagramáticos como estratégia de apresentação, enquanto a segunda aborda a síntese analítica das estratégias de composição no projeto. Considerando que proposição e análise são dois exercícios complementares e necessários ao projeto e que se retroalimentam constantemente (como o diálogo permanente e necessário entre prática, ensino e pesquisa), propomos uma reflexão preliminar sobre o papel do exercício de síntese gráfica e textual (o diagrama) e seu impacto na Arquitetura Contemporânea. Metodologicamente, foram estudados projetos em situação de concurso (em particular, o Concurso Internacional para o Museu Guggenheim de Hensinki), por se tratarem de eventos que, por sua natureza, são exercícios de síntese propositiva e analítica, em que a retórica diagramática exerce papel fundamental no projeto e no julgamento qualitativo.
METADESENHO: UMA ANÁLISE SOBRE O PROJETO DA SEDE SOCIAL DO CLUBE HARMONIA, DE FÁBIO PENTEADO.
Authors: Giroto Ivo Renato
Published: December 2021

Este artigo analisa um dos projetos mais conhecidos do arquiteto paulista Fábio Moura Penteado: a Sede Social do Clube Harmonia (1964). Reconhecido como uma obra paradigmática da chamada Escola Paulista, o projeto do clube oferece uma abertura interpretativa que abrange, além das estratégias e intenções do projeto de Penteado, a realidade social brasileira da época, o discurso arquitetônico e político do grupo paulista, e o papel da arquitetura como agregador e agente de transformações sociais. A obra analisada demonstra a potência de uma relação simbiótica entre intenção e materialidade, plasmada no equilíbrio entre um discurso político-social e no manejo competente de questões perceptivas e sensoriais. A arquitetura nega o metaforicamente o isolamento e a segregação que a ideia de clube transmite, revelando uma veemente dimensão didática, porém sem ser impositiva ou sisuda. Através do recurso consagrado pelos paulistas de conter o programa em uma caixa única, Penteado cria um envolvente cerrado e sólido por fora, que quase se desmaterializa internamente através da articulação dos níveis dos pisos, tratados como uma progressão sequencial de espaços. O edifício requer ludicamente a participação do usuário e conecta idealmente a rua ao interior, negando metaforicamente qualquer conotação de exclusão ou proibição. O projeto do Clube Harmonia se define como uma forma alegre de comunicar valores sociais integradores, exatamente no lugar onde menos se espera encontrá-los.