bluuebunny/crossref_metadata_2025 huggingface dataset:
Exploring Glucocorticoid Safety: Insights from pKCSM Predictions on Tolerability and Toxicity Profiles
Authors: ferrari Ivan
Published: September 2024

This comprehensive analysis aims to offer valuable insights into the safety profiles of these glucocorticoids, facilitating the identification of compounds with potentially reduced adverse effects. This study investigates the toxicity profiles of various glucocorticoids, utilizing predictions from the pKCSM Server. Among the glucocorticoids examined, Dexamethasone, Triamcinolone, Hydrocortisone hemisuccinate, Paramethasone, Fluprednisolone, and Flumethasone emerge as potentially less toxic, displaying favorable scores across diverse parameters such as Max. Tolerated Dose (human, MRT), Oral Rat Acute Toxicity (LD50), and Oral Rat Chronic Toxicity (LOAEL). Notably, Hydrocortisone hemisuccinate and Triamcinolone stand out for their high tolerability capacity based on the Max. Tolerated Dose (human, MRT), suggesting enhanced safety profiles. These findings contribute insights into selecting glucocorticoids with optimal safety and tolerability for potential therapeutic applications.Further research and clinical investigations are warranted to validate and refine these findings, ensuring the responsible and effective use of glucocorticoids in medical practice.
Impact of Gut Microbiota and SCFAs in PCOS Pathogenesis and Metformin on Therapy
Authors: Kukaev Evgenii , Kirillova Ekaterina , Tokareva Alisa , Rimskaya Elena , Starodubtseva Natalia , Chernukha Galina , Priputnevich Tatiana , Frankevich Vladimir , Sukhikh Gennady
Published: September 2024

Polycystic ovary syndrome (PCOS) is a complex disorder that impacts both the endocrine and metabolic systems. The gut microbiota plays a crucial role in in metabolism regulation and immune responses through its interaction with the external environment. This article explores the intricate interplay between intestinal flora and the pathogenesis of PCOS, focusing on the pivotal role of microbial metabolites, specifically short-chain fatty acids (SCFAs). SCFA levels in fecal and blood samples from women with PCOS (n=69) and healthy controls (n=18) were analyzed using Gas Chromatography-Mass Spectrometry (GC/MS) for precise measurement. The results revealed that women with PCOS exhibited a significant reduction in beneficial bacteria alongside a notable overgrowth of opportunistic microorganisms. An overproduction of acetic acid (AA) and valeric acid (VA) in fecal samples suggests a link between elevated SCFAs and the development of obesity and PCOS. Interestingly, AA in the bloodstream might offer a protective effect against PCOS by ameliorating key symptoms such as high body mass index (BMI), insulin resistance (IR), and chronic inflammation. This finding points to the potential therapeutic value of maintaining optimal AA levels in the blood. Although serum SCFA levels showed non-significant changes following metformin treatment, the normalization of AA in the gut underscores that metformin exerts a more pronounced effect locally within the gastrointestinal tract. This treatment also led to an increase in beneficial gut bacteria and a reduction in opportunistic pathogens, suggesting a restoration of gut microbial balance. Furthermore, the study identified the most effective model for predicting the success of metformin therapy, based on serum concentrations of butyric acid (BA) and VA, achieving a 91% accuracy rate, 100% sensitivity, and 80% specificity. These promising findings highlight the potential for developing targeted interventions and personalized treatments, ultimately improving clinical outcomes for women with PCOS.
Evaluation of a Point of Care Gem Premier ChemSTAT Analyzer in Emergency Department: Prevention of Contrast-Induced Nephropathy and Optimization of Patient Flow
Authors: Brailova Marina , Audin Marie , Raconnat Julien , Bouillon-Minois Jean-Baptiste , Schmidt Jeannot , Pereira Bruno , Bouvier Damien , Sapin Vincent
Published: September 2024

Background: Having a laboratory renal profile for medical imaging examinations requiring contrast media (CM) administration is strongly advised. Creatinine helps identify patients at risk of contrast-induced nephropathy (CIN). GEM® Premier™ ChemSTAT (Werfen) is a point-of-care (POC) analyzer with 12 emergency parameters including creatinine assay. The aim of this study consists to compare ChemSTAT with the central analytical solution of the University Hospital of Clermont-Ferrand and to evaluate the interest of the POC creatinine in the emergency department (ED) in optimizing the flow of patients, especially if CM used.
Methods: More than 200 whole blood (WB) samples from the ED were evaluated on the ChemSTAT analyzer. As comparative methods, the plasma aliquots from the same samples were assayed on an Atellica® CH (Siemens Healthineers). The clinical concordance was assessed ac-cording the decision cut-offs of the French Society of Radiology for the risk of CIN. The availability times of biological results between ChemSTAT and the central laboratory were studied.
Results: WB results from ChemSTAT correlated well with those from Atellica® CH, except for tCO2 (known bias between Siemens and Cobas Roche methods predicting ChemSTAT values). The results of creatinine assay allow to have identical medical decisions compared to the renal risk cut-offs. The availability of biological results is reduced by 50 min on average with ChemSTAT vs the central laboratory. Computed tomography was performed for 44.7% of patients including the injection of the CM in 68% of cases. For these patients, the availability of creatinine results relative to imaging time is faster with the ChemSTAT on average of 45.2 min.
Conclusions: Great analytical and clinical correlations for creatinine assay allow safe iden-tification of patients at risk of CIN and improve patient flow in ED especially for those requiring computed tomography with use of CM.
Microplastic Aerosol Contamination in Porto (Portugal)
Authors: Logvina Yuliya , Moreira Diogo Silva , Santos Rui P.M. , Neves Inês Filipa , Ribeiro Helena , Pinto da Silva Luís , Silva Joaquim Esteves da
Published: September 2024

Microplastic pollution, particularly particles smaller than 5 mm, poses significant environmental and health risks due to their potential for long-range transport and inhalation. This study provides the first long-term assessment of airborne microplastics in Porto, Portugal, over 18 months (September 2022 to March 2024). Bi-weekly samples were collected using a Microplastic Collector NILU, which were size-fractionated into five categories (>125 μm, 125-63 μm, 63-25 μm, 25-12 μm, and 12-1.2 μm), and quantified via optical microscopy. Microplastics (26 to 1,484 MPs/day/m²) and fibers (14 to 646 fibers/day/m²) showed increasing pollution trends. With a focus on the 12-1.2 μm size-range due to its classification as PM10 and PM2.5, the highest microplastic concentrations were 164 MPs/day/m² (12-1.2 μm) and 534 MPs/day/m² (25-12 μm). Recovery rates of methodology varied among polymers, with PP, PE-HD, and ABS showing high accuracy (75.9%) and PES significantly lower (26.5%). The study highlights significant temporal variability in airborne microplastic pollution, increasing trends, and the need for ongoing monitoring and targeted mitigation strategies to address associated health risks.
Intrapartum Electronic Cigarette Use and Birth Outcomes: Evidence from a Population-Based Study
Authors: Azar Michelle , Oatey M Elena , Moniz Michelle , Bailey Beth A
Published: September 2024

Harms of combustible cigarette (CC) use in pregnancy for fetal development are well-studied. Less understood is potential impacts of newer non-combustible cigarette alternatives, including electronic cigarettes (EC). Our goal was to examine whether EC use during pregnancy predicts increased risk of adverse birth outcomes. This retrospective cohort study used data from the Obstetrics Initiative (OBI), a statewide collaborative of 70 maternity hospitals. OBI’s clinical registry of data on nulliparous, term, singleton, vertex fetal presentation pregnancies were from medical records. Three groups of pregnancy cigarette users (Controls (n=26,394), CC (n=2,216), EC (n=493) were compared on birth outcomes, controlling for background differences. Compared to controls, the EC group had significantly lower birth weight, while CC had reduced birthweight and greater rates of arterial cord pH < 7.1. Compared to EC, CC users had higher rates of neonates requiring antibiotics and NICU admission. Growing evidence suggests EC are not safer alternatives to CC, and use during pregnancy should be discouraged. Additional research is needed, as non-significant trends for increased risk of several adverse neonatal outcomes following EC use were found, potentially significant in larger studies with average-risk for adverse pregnancy outcomes and when frequency and timing of EC exposure are considered.
The Ramifications of Darwin's "On the Origin of Species": From Eugenics to Modern Genomics
Authors: Montgomery Richard Murdoch
Published: September 2024

This article delves into the historical development and ramifications of divergent theories that have emerged since the publication of Darwin's seminal work, "On the Origin of Species" in 1856. It traces the evolution of thought from Darwin's revolutionary ideas through the controversial era of eugenics, the groundbreaking discovery of DNA, the elucidation of Mendelian genetics, and the subsequent development of modern genetic theories. The article also explores the critical role of mathematical models, statistics, and data science in advancing genomics research over the last decade. This comprehensive exploration highlights how these theories and methods have fundamentally shaped our understanding of biology, evolution, human genetics, and complex biological systems.
Parameters Variation of Natural Gas Hydrate with Thermal Fluid Dissolution Based on Multi-field Coupling under Pore-Scale Modeling
Authors: Li Zhengyi , Wang Zhiyuan , Ji Hongfei
Published: September 2024

The permeability, heat conductivity and reaction rate will be varied with the change of natural gas hydrate saturation, when thermal fluid injected into the natural gas hydrate reservoirs. In order to characterize the variation of physical field parameters with hydrate saturation, DDF-LBM was applied to simulate the hydrate dissolving process by thermal fluid injection under pore scale modelling. Based on the forced conjugate heat transfer case, the relaxation frequency of the thermal lattice in the pores is corrected. Based on the P-T phase equilibrium relationship of hydrates and considering the heat absorbed by the hydrate reaction, the solid-liquid state of the hydrate lattice is judged in real time, and the dynamic simulation of the heat flow solidification multi-physics field is realized. The simulation results show that the dissolution rate of hydrates by thermal fluid injection was higher than that by heating the hydrate surface alone, and was positively correlated with the hydrate saturation. On the basis of the above results, this paper provided exponential fitting equations between different hydrate saturations and average permeability, effective thermal conductivity, and inherent reaction rate. The fitting results show that saturation has a negative correlation with relative permeability and effective thermal conductivity, and a positive correlation with the inherent reaction rate. The above results can provide a reference basis for accurately describing the heat and mass transfer of natural gas hydrate under macro-scale.
QUANTITATIVE ANALYSIS IN MILK CYTOLOGICAL TESTS BASED ON ARITHMETIC AND GEOMETRIC MEANS
Authors:   Department of Animal Reproduction, Poznań University of Life Sciences, Poznań, Poland, DUDKO Przemysław , WINIARCZYK Stanisław ,   Department of Epizootiology and Infectious Diseases, University of Life Sciences in Lublin, Lublin Poland, MIEDZOBRODZKI Jacek ,   Department of Microbiology, Jagiellonian University, Kraków, Poland, WÓJCIK Piotr ,   The National Research Institute of Animal Production, Balice near Kraków, Poland, PRUCIAK Agata ,   Department of Computer Science and Statistics, University of Medical Sciences in Poznań, Poznań, Poland, KURPISZ Maciej ,   Institute of Human Genetics, Polish Academy of Sciences, Poznań, Poland
Published: September 2024

The aim of this study was to evaluate mathematical tests allowing a more precise statistical analysis of the SCC values contained in a millilitre of milked milk and measured with an electronic counter. The study was conducted on a herd of 800 hf cows (100%) with an average yield of ~9,500 kg of milk, which were kept in cubicles in a free-stall system. The analyses carried out showed that a comparison of the Nelson Philpot coefficient column values with the values of the other parameters and with the course of their curves suggests that the course of the geometric mean and natural logarithm curves was the most similar – but not identical – to the fluctuations in the height of the linear index columns. It should be pointed out, however, that the values of this logarithm turned out to be ~3.7 times greater than the linear coefficient, and the first of these averages was as much as ~50 times greater than the aforementioned coefficient. Despite the ever-increasing number of electronic counters used for quantitative cytological milk tests, the use of field cellular reaction tests (TOK or CMT) will not decrease at all. It is necessary, though, to sample more precisely and to harmonise the data of the linear Philpot index and the interpretation of the former Drury–Reed index. At the same time, since the dairy industry has already accepted the natural logarithm and the geometric mean in milk assessment, threshold values for SCC should also be established for these by means of an appropriate field trial. As it was noted in the study, each of the averages had its advantages and disadvantages; it would be worthwhile to assess the harmonic and quadratic averages similarly (observation under natural conditions).
THE IMPACT OF SELECTED SOMATOTROPIC AXIS GENES ON THE MILK PERFORMANCE TRAITS OF SHEEP, GOATS AND CATTLE
Authors:   Department of Monogastric Animal Science, Faculty of Biotechnology and Animal Husbandry, West Pomeranian University of Technology in Szczecin, FIJAŁKOWSKA Aurelia , SZEWCZUK Małgorzata Anna ,   Department of Monogastric Animal Science, Faculty of Biotechnology and Animal Husbandry, West Pomeranian University of Technology in Szczecin, OSTER Nicola ,   Department of Monogastric Animal Science, Faculty of Biotechnology and Animal Husbandry, West Pomeranian University of Technology in Szczecin, STANKIEWICZ TOMASZ ,   Department of Animal Reproduction Biotechnology and Environmental Hygiene, Faculty of Biotechnology and Animal Husbandry, West Pomeranian University of Technology in Szczecin, BŁASZCZYK Barbara ,   Department of Animal Reproduction Biotechnology and Environmental Hygiene, Faculty of Biotechnology and Animal Husbandry, West Pomeranian University of Technology in Szczecin, KLIMCZAK Izabela ,   Department of Monogastric Animal Science, Faculty of Biotechnology and Animal Husbandry, West Pomeranian University of Technology in Szczecin
Published: September 2024

The aim of the present article was review of associative research concerning polymorphisms located in growth hormone receptor (GHR), insulin-like growth factor-1 (IGF-1) and Janus kinase 2 (JAK2). Improvement of ruminants production traits is closely related with identification of polymorphisms in the somatotropic axis. This genetic variation can have a positive effect on increasing milk production. The growth hormone receptor effects the metabolism of proteins, carbohydrates and lipids, while Janus kinases as transcription factors directly regulate genes involved in milk secretion in the mammary gland. Genetic factor could have a beneficial effect on increasing milk yield, and therefore, the application of marker-assisted selection can contribute to the faster identification of animals with better genetic predispositions.
PROPOSAL OF THE MONITORING FOR THE ALPINE NEWT ICHTYOSAURA ALPESTRIS
Authors:   Faculty of Animal Breeding, Bioengineering and Conservation, Warsaw University of Life Sciences – SGGW, Warszawa, Poland, KULIS Zuzanna
Published: September 2024

Alpine newt Ichthyosaura alpestris belongs to the group of amphibians, which is particularly vulnerable to the negative effects of the degradation of aquatic habitats. Destruction and fragmentation of potential breeding and living sites occur due to intensive landscape transformations, construction works, or drainage treatments. In addition, climate change is affecting the availability of water resources, which may result in a reduction of breeding sites. Although the alpine newt is still considered a Least Concern species by the IUCN (2023), is given to disappear. However, in view of the risks both now and in the future, it is necessary to monitor the presence and breeding sites and their protection constantly. The article describes a proposal for research and monitoring methods for the alpine newt. Periodic inventories of complexes of potential water reservoirs should be carried out in search of adult specimens, mating in spring and early summer, and later developing larvae. Observation and scouring using a herpetological scoop to survey the bottom and vegetation of a water body for individuals and eggs. In addition, it is worth carrying out a Habitat Suitability Index (HSI), as suggested in this article.This will allow for monitoring of the local population status and the introduction of conservation measures for the species in a given area at the right time.
THE EFFECTS OF LTF AND TNFα GENES ON MILK PRODUCTION ARE DEPENDENT ON LACTATION STATE
Authors:   Department of Genetics, West Pomeranian University of Technology Szczecin, Poland, WOJDAK-MAKSYMIEC Katarzyna , SZYDA Joanna ,   Department of Genetics, Wrocław University of Life Sciences, Wrocław, Poland, STANISŁAWCZYK Anna ,   Department of Genetics, West Pomeranian University of Technology Szczecin, Poland
Published: September 2024

So far, a lot of studies have focused on the genetic background of bovine milk production traits and applied heritability models which assumed that the effects of individual genes add up in a simple way and remain unchanged throughout a cow’s life, independently of external and internal factors. The aim of this research study was to verify this assumption by checking if the effects of individual alleles of LTF (substitution C/T in exon 3) and TNFα (substitution T/C in intron 6) are variable and depend on a cow’s internal environment (physiological state). The genetic material used in the study was collected from black-and-white Holstein-Friesian cows kept in a single barn in Poland. Daily milk yield and percentage content of fat, protein and lactose were examined once a month on the basis of test-day milkings. The study results show that the effects of individual LTF and TNFα gene alleles vary throughout lactation, that is they depend on a cow’s physiological state.
The Accuracy of Artificial Intelligence Models in Hand/Wrist Fracture and Dislocation Diagnosis
Authors: Wong Chloe R. , Zhu Alice , Baltzer Heather L.
Published: September 2024

Background:

Early and accurate diagnosis is critical to preserve function and reduce healthcare costs in patients with hand and wrist injury. As such, artificial intelligence (AI) models have been developed for the purpose of diagnosing fractures through imaging. The purpose of this systematic review and meta-analysis was to determine the accuracy of AI models in identifying hand and wrist fractures and dislocations.

Methods:

Adhering to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Diagnostic Test Accuracy guidelines, Ovid MEDLINE, Embase, and Cochrane Central Register of Controlled Trials were searched from their inception to October 10, 2023. Studies were included if they utilized an AI model (index test) for detecting hand and wrist fractures and dislocations in pediatric (<18 years) or adult (>18 years) patients through any radiologic imaging, with the reference standard established through image review by a medical expert. Results were synthesized through bivariate analysis. Risk of bias was assessed using the QUADAS-2 tool. This study was registered with PROSPERO (CRD42023486475). Certainty of evidence was assessed using Grading of Recommendations Assessment, Development, and Evaluation.

Results:

A systematic review identified 36 studies. Most studies assessed wrist fractures (27.90%) through radiograph imaging (94.44%), with radiologists serving as the reference standard (66.67%). AI models demonstrated area under the curve (0.946), positive likelihood ratio (7.690; 95% confidence interval, 6.400-9.190), and negative likelihood ratio (0.112; 0.0848-0.145) in diagnosing hand and wrist fractures and dislocations. Examining only studies characterized by a low risk of bias, sensitivity analysis did not reveal any difference from the overall results. Overall certainty of evidence was moderate.

Conclusion:

In demonstrating the accuracy of AI models in hand and wrist fracture and dislocation diagnosis, we have demonstrated that the potential use of AI in diagnosing hand and wrist fractures is promising.

Level of Evidence:

Level III. See Instructions for Authors for a complete description of levels of evidence.
From research to production : lessons learned and best practices
Authors: May Trent , Clement Thomas , Miller John , Carleton Charles , Webber Aaron , Williams Samuel
Published: September 2024

This paper provides an overview of best practices to assist individuals and teams in transitioning software from a research product into a production environment. The information contained in this paper consists of best practices and lessons learned from an assignment consisting of transitioning a science-based research suite of programs into a more modern software format with appropriate preparations and considerations to be deployed in a production environment. The original software suite was written using both MATLAB and Python programming languages, and the new production version was written in the Python programming language.
Effect of Halal Label on Product Packaging on Muslim Consumer Purchase Decision
Authors: Labolo Sultan Nanta Setia Dien , Nurul Arsyi Alfansyuri , Khairani Novita
Published: September 2024

The halal label is an important thing in society, especially for Indonesian people, the majority of whose population adheres to Islam. Researchers found that there are several food products consumed by Muslims that have not included a halal label. Mini Market Latansa Gontor 5 of the 100 products sold 20 of them have not been labelled halal, which means 20% do not have a halal label. The methodology that researchers use is quantitative which is a field survey by taking a sample of 130 teachers of Pondok Modern Darussalam Gontor 5 Magelang. The purpose of this study was to determine whether there is an influence and how much influence the halal label has on the interest in purchasing food products at Mini Market Latansa Gontor 5. The data obtained is then processed using the IBM SPSS v.21 application. The results obtained are, of the 20 statements with an error rate of 5%, rCount is greater than rTable with a value level of 0.159, meaning that all statements are valid. The reliability test obtained a Cronbach alpha value of 78.9% for questionnaire X (halal label) and 88.3% for questionnaire Y (consumer purchase interest) greater than 60%, meaning that both questionnaires are reliable. From the results of the simple linear regression test, the probability number is 0.000, which is smaller than 0.5, meaning that there is a significant relationship between X (halal label) and Y (consumer purchase interest). From the results of the T test, it is obtained that the Thitung amount of the level of influence of halal labelling on purchasing interest is 11.398 greater than 1.97838, meaning that variable X has a real influence on variable Y. From the results of the detirminization coefficient test (R2), the result is 0.504, meaning that the level of influence of variable X (halal label) on variable Y (consumer purchase interest) is 50.4%, while the remaining 49.6% is influenced by other factors not examined in this study.
Optimizing Waqf Management For Social Impact
Authors: Nurfattah Arizqiya , Bachtiar Royyan
Published: September 2024

Waqf is a distinctive instrument in the Islamic financial system that aims to provide social and economic benefits to society. In Indonesia, waqf has great potential to improve people's welfare, support social and economic development, and advance various sectors in the country, such as issues of access to education and health, among others. This is inseparable from the optimal management of waqf management which is the life of waqf sustainability. This paper reviews good waqf management supported by all aspects including digital aspects, and discusses the challenges faced by the development of digital technologies such as websites, blockchains, and so on in facilitating the management and development of waqf in Indonesia so that it can follow the pattern of steps in the digital era. The results of the study explain that digital innovations such as websites, blockchain, and others are very helpful in carrying out clearer and more accountable waqf management. In other words, the welfare of the state and society is supported by social activities derived from waqf assets, productive investment, and Sharia compliance. Optimal waqf management involves all aspects consisting of sharia compliance, regulations, and the use of adequate technology that has an impact on social activities, education, and even productive investment of waqf assets.
ANALISIS PENEGAKAN HUKUM PELAKU BULLYING TERHADAP MAHASISWA BARU UNIVERSITAS BENGKULU DALAM PERSPEKTIF HUKUM DAN MASYARAKAT
Authors: Pratiwi Farida Hesti
Published: September 2024

Abstrak
Permasalahan perpeloncoan dalam bentuk bullying dalam kegiatan Pengenalan Kehidupan Kampus Mahasiswa Baru (PKKMB) merupakan fenomena yang serius dan membutuhkan penanganan yang tegas. Artikel ini bertujuan untuk menggali lebih dalam tentang fenomena tersebut, memahami penegakan hukum terhadap kasus perpeloncoan, dan menganalisis perspektif hukum dan masyarakat terhadap kasus tersebut. Metode penelitian yang digunakan adalah penelitian yuridis-empiris untuk menganalisis penegakan hukum terhadap pelaku bullying. Berdasarkan pembahasan, ditemukan bahwa perpeloncoan dalam PKKMB sering kali melibatkan tindakan yang merendahkan, mengintimidasi, dan bahkan membahayakan mahasiswa baru. Penegakan hukum terhadap kasus-kasus perpeloncoan harus dilakukan secara adil dan tegas. Dalam perspektif hukum dan masyarakat, peraturan dan kebijakan yang ada harus dipastikan relevan dan responsif terhadap perkembangan sosial.
Kata kunci: Perpeloncoan, Bullying, Hukum dan Masyarakat
PENYELESAIAN SENGKETA PERDATA TENTANG TANAH DALAM PERSPEKTIF HUKUM AGRARIA DI INDONESIA
Authors: Zacharias Vasco Javarison
Published: September 2024

Penyelesaian sengketa tentang pertanahan adalah suatu upaya menyelesaiakan perselisih antar dua orang atau libih yang merasa haknya dilanggar oleh orang lain. Segala sesuatu yang mengatur hak dan tanggung jawab pihak-pihak yang terlibat dalam urusan pertanian dikenal dengan “hukum agraria”. Hal ini mencakup peraturan hukum yang terkodifikasi dan tidak terkodifikasi. Karena ikatan yang tidak dapat dipisahkan antara tanah dan manusia. Karena tanah sangat penting bagi kelangsungan hidup manusia, maka manusia mempunyai hubungan yang sangat erat dengan tanah. Namun kenyataannya masih banyak masyarakat yang memanfaatkan situasi ketika penegakan hukum lemah, sehingga menyebabkan meningkatnya konflik pertanahan. Terdapat metode penyelesaian konflik di dalam pengadilan maupun di luar pengadilan. Tahapan ini diharapkan dapat menyelesaikan permasalahan pertanahan antar masyarakat. Tujuan dari penelitian ini adalah untuk mengkaji mekanisme penyelesaian sengketa pertanahan melalui litigasi dan non-litigasi, termasuk mediasi, arbitrase dan negosiasi. Selain itu, penelitian ini juga menganalisis peran lembaga peradilan, Badan Pertanahan Nasional (BPN) dan mekanisme penyelesaian sengketa yang diatur dalam Undang-Undang Pokok Agraria
Efektivitas Aplikasi Powtoon Dalam Mengembangkan Media Pembelajaran Di TK Aisyiah Jogorogo
Authors: Rahmadania Adzimatinoor nabila
Published: September 2024

Kurangnya inovasi dalam mengembangkan media pembelajaran seringkali menyebabkan proses pembelajaran menjadi tidak efektif dan kurang diminati siswa. Hal inilah yang mendorong pelaksanaan program Kuliah Kerja Nyata Tematik (KKN T) dalam mengembangkan media pembelajaran dengan memanfaatkan teknologi digital di TK/KB Aisyiyah Jogorogo, Dusun Jogorogo, Desa Jogorogo, Kecamatan Jogorogo, Kabupaten Ngawi, Jawa Timur. Adapun metode yang digunakan adalah melibatkan observasi, di mana data dikumpulkan untuk mencatat kondisi atau potensi TK/KB Aisyiah Jogorogo di mana mahasiswa KKN melakukan tugasnya. Informasi terkumpul melalui beragam teknik, termasuk pengamatan langsung di lapangan, wawancara dengan pihak sekolah seperti Kepala sekolah dan guru lainnya, serta studi dokumen dan catatan yang ada di kelas. Setelah data terkumpul, langkah berikutnya adalah menganalisisnya menggunakan metode analisis yang sesuai dengan kebutuhan. Dan tujuan dari penelitian ini adalah meningkatkan pengetahuan anak mengenai huruf hijaiyyah pada anak usia dini dengan mengembangkan metode dan media pembelajaran Video Animasi menggunakan aplikasi Powtoon yang disesuaikan dengan tahapan perkembangan anak, terutama di TK/KB Aisyiah, Jogorogo, Jogorogo, Ngawi, dan juga memudahkan siswa untuk mengetahui doa disetiap gerakan shalat.
IMROVING THE STUDENTS’ SKILLS OF MUHADHOROH AT MUHAMMADIYAH BOARDING SCHOOL AL MUKHTAR WATUKEBO THROUGH POWER VOICE TECHNIQUES
Authors: Huwaida Hasna'
Published: September 2024

Islamic da'wah has traditionally been conducted through lectures; the Prophet Muhammad himself served as an example of this practice. It's true that not everyone has the ability to lecture soon after birth. This skill has to be regularly taught and practiced. The goals of the Muhadhoroh operations, which were supported by MBS Al Mukhtar Watukebo, were impeded by a number of issues. Among these are the students' lack of confidence when rehearsing speeches and the speakers' repetitive methods, which make the students bored. This exercise concentrates on these two issues by providing guidance and support for students to improvise their speech abilities in muhadhoroh activities using power voice techniques, a method that is frequently employed. The findings from observations, conversations, and interviews with officials at MBS Al Mukhtar revealed notable shifts in the students' passion and interest in giving presentations. This is in line with the training activities' goals, particularly when using power voice techniques during Muhadhoroh activities.
PENDAMPINGAN PENGEMBANGAN TEKNOLOGI DIGITAL UNTUK MENINGKATKAN JANGKAUAN PEMASARAN INDUSTRI TAS ANYAMAN DESA SUKOREJO, PONOROGO
Authors: Arifah Dian Afif , Syaifullah Muhammad Dhiya'
Published: September 2024

Kabupaten Ponorogo memiliki sentra industri berupa UMKM Tas Anyaman Krajan Desa Sukorejo yang telah menjadi produk khas daerah yang potesial untuk meningkatkan perekonomian warga. Sebagian besar produk pengrajin dipasarkan secara lokal dan beberapa ke luar daerah Ponorogo. Upaya peningkatan pemasaran perlu diterapkan untuk memperluas jangkauan produk dan meningkatkan pendapatan industri. Pengembangan berbasis e-commerce dan teknologi informasi dinilai paling efektif sesuai dengan kebutuhan industri dan perkembangan teknologi. Namun keahlian dan fasilitas yang dimiliki pengrajin masih kurang. Program ini bertujuan untuk memberikan pendampingan dan memberdayakan warga dalam upaya peningkatan Jangkauan Pemasaran Industri Tas Anyaman Krajan Desa Sukorejo, Ponorogo sebagai mitra sasaran program.  Program dilaksanakan oleh tim pengabdian dalam program KKN Tematik UNIDA Gontor yang dilaksanakan selama 3 pekan (4-27 Maret 2024). Beberapa kegiatan strategis yang dilakukan antara lain pendampingan perijinan industri, sosialisasi dan pelatihan pengelolaan e-commerce sebagai solusi pemasaran, dan pengembangan website desa. Ketercapaian program dilakukan dengan mengukur pengetahuan dan ketrampilan peserta, ketersediaan e-commerce dan website desa dan peningkatan pemasaran produk. Hasil evaluasi program menunjukkan bahwa strategi yang dilakukan, efektif dalam meningkatkan pengetahuan dan keterampilan peserta dan menghasilkan fasilitas berupa e-commerce produk dan website profil desa Sukorejo. Saran untuk keberlanjutan program adalah dengan melibatkan pemerintah desa untuk mengelola dan meninjau program secara berkala, dan juga mempertimbangkan aspek-aspek pemasaran lain untuk meningkatkan kualitas produk.
Higher urban heat hazard in wealthier neighborhoods in the Global South
Authors: Chakraborty TC
Published: September 2024

Urbanization leads to local warming in addition to background climate change, which disproportionately impacts society due to the high population densities of cities. Scientific and media discourse around urban heat is often framed around intra-urban differences in hazard and exposure due to the spatial heterogeneity of cities and segregation of urban sub-populations. Since almost all multi-city assessments of income-based heat disparities are from the U.S., it is important to examine whether these patterns are replicated for cities in the Global South. Here, we use various gridded datasets, including satellite-derived estimates, to demonstrate that wealthier urban neighborhoods generally have higher heat hazard in the Global South, the opposite of the results seen for U.S. cities. This is because income/wealth distributions within these cities result from their unique cultural history and population-level living preferences, and do not follow typical U.S. patterns. Parallel analyses of intra-urban vegetation distributions, which modulate heat hazard, show more nuanced relationships with income, though the general results still differ from the those for the U.S. We recommend being cautious about treating scientific evidence from U.S. cities as the universal norm for understanding intra-urban heat risk and encourage more comprehensive urban heat vulnerability studies for the Global South.
Response of Portulaca olearacea and its rhizospheric microbiome to the application of slumgum from beekeeping industry transformed with Penicillium chrysogenum
Authors: Carrascosa Angel , Pascual Jose Antonio , Cuartero Jessica , García-Romera Inmaculada , Silva-Castro Gloria Andrea , De Santiago Ana , Ros Margarita , Petropoulos Spyridon Alexandros , Alguacil Maria del Mar
Published: September 2024

In the beekeeping industry, “slumgum” is generated as a solid organic waste during the beeswax-rendering process from old scraped honeycombs. This bio-waste could be considered as a novel organic fertilizer due to its high content in organic matter and nutrients. As a novelty in this study, we analysed the effect of application of solid and liquid slumgum transformed or not with Penicillium chrysogenum on purslane (Portulaca oleracea) yield and its relationship with soil rhizosphere. For this purpose, nutritional composition, enzymatic activities involved in the P, N and C cycles, fungal and bacterial community composition, diversity and potential functionality in the rhizosphere were measured. The application of solid and liquid slumgum transformed with P. chrysogenum (TS and TL, respectively) and slumgum liquid (L) significantly increased purslane shoot biomass and foliar P content, compared to the non-transformed solid slumgum (S). The different types of slumgum tested resulted in changes in the composition of both bacteria and fungi communities, resulting in distinct communities for each treatment. Moreover, changes in the functional fungal guilds were observed, with increased abundances of saprotrophs and reduced number of plant pathogens under the TS, TL, and L treatments. Solid slumgum transformed with P. chrysogenum (TS) was also the most effective in enhancing enzymatic activities related with C, N and P cycles in the rhizosphere. Conversely, the use of solid slumgum (S) led to an increase in the abundance of bacterial genes primarily associated with the denitrification process. Our preliminary results suggest that solid and liquid slumgum transformed with P. chrysogenum, as well as liquid non-transformed slumgum (TS, TL, and L, respectively), could be considered as novel organic fertilizers, amendments or additives within the circular economy context and the sustainable use of natural resources. Nevertheless, further studies are necessary to validate the positive outcomes observed, particularly under field conditions and with a variety of species.
Remarkable pattern of global warming in ocean heat content
Authors: Trenberth Kevin , Cheng Lijing , Pan Yuying , Fasullo John , Mayer Michael
Published: September 2024

Huge heat anomalies in the past few years are not explained by climate models1. Strong characteristic patterns in temperatures for upper layers of the ocean occurred from 2000 to 2023 in the presence of global warming from increasing atmospheric greenhouse gases2. Here we show that the deep tropics are warming, although sharply modulated by El Niño-Southern Oscillation events, with strong heating in the extratropics near 40°N and 40 to 45°S, but little heating near 20°N and 25-30°S. The heating is most clearly manifested in zonal mean ocean heat content and is evident in sea surface temperatures. Strongest heating is in the Southern Hemisphere, where aerosol effects are small. Estimates are made of the contributions of top-of-atmosphere (TOA) radiation, atmospheric energy transports, surface fluxes of energy, and redistribution of energy by surface winds and ocean currents. The patterns are not directly related to TOA radiation but are strongly evident in net surface energy fluxes. Changes in the atmospheric circulation, jet streams, and storm tracks are reflected in surface ocean Ekman transports. As well as climate change, natural variability is likely in play. Hence the atmosphere and ocean currents are systematically redistributing heat from global warming, profoundly affecting local climates.
Affinity of Drug Candidates Binding to SARS CoV-2 PLpro Assessed Using a Generalized-ensemble Method
Authors: Muramoto Masashi , Hikiri Simon , Saito Suzuka , Qilin Xie , Kasahara Kota , Higo Junichi , Takahashi Takuya
Published: September 2024

To establish a procedure for screening compounds that inhibit ligand–receptor binding, we used a multidimensional virtual- system coupled molecular dynamics (mD-VcMD), which is a generalized ensemble method developed by ourselves recently. In this sampling method, the compound was put at a distant point from the receptor in the initial conformation of simulation. Both the receptor and the compound were fully flexible in explicit solvent during sampling. The mD-VcMD produced a free-energy landscape of the compound–receptor binding, where a probability of existence was assigned to each sampled conformation. We examined four compounds binding to the papain-like protease (PLpro) of SARS-CoV-2. The resultant free-energy landscapes were funnel-like for all compounds. The probability assigned to the free-energy basins showed good correlation with the measured association constants. Furthermore, structural clustering identified binding modes of two types existing in the free-energy basin. The probability assigned to the binding modes showed good correlation with the measured enzyme-inhibitory. These results suggest that this proposed procedure is useful to select a candidate compound (inhibitor) from examined compounds.
Network analysis of perceived stress and burnout among Chinese nurses
Authors: Suo Xingbo , Zhang Yang , Zhang Yi , Zhang Shenshuai , Tian Jing , Wan Xin , Yuan Xin , Zhai Jinguo , Gao Jin , Hu Maorong
Published: September 2024

Background
Burnout poses a significant threat to clinical nurses' mental health and the quality of healthcare services. This study constructed a burnout-perceived stress network model and explored its associations with job satisfaction.
Methods
An online cross-sectional survey was conducted from November 13 to December 15, 2023, across 23 hospitals in China. The Chinese versions of the Perceived Stress Scale, the Maslach Burnout Inventory General Survey, and the Nurse Working Satisfaction Scale were used to assess stress, burnout, and job satisfaction, respectively. Network analysis was employed to identify central nodes and bridges in the burnout-perceived stress network and their connections to job satisfaction.
Results
"Good at job" demonstrated the highest expected influence in the entire stress-burnout network, followed by "Stressed" and "Less enthusiasm". "Contributing", "Effective", "Felt yourself on top of things", and "Confident about the ability to handle personal problems" were identified as the most critical bridge symptoms connecting the stress-burnout network. Within the burnout community, "Contributing" and "Doubt significance" showed the strongest direct associations with job satisfaction.
Conclusion
Burnout-related symptoms play a crucial role in the central nodes, bridge symptoms, and associations with job satisfaction within the stress-burnout network of clinical nurses. These symptoms have significant implications for improving the quality of work life for nursing staff.
Is CD45 the cause of the increased incidence of intracranial aneurysm and aneurysmal subarachnoid hemorrhage? a mendelian randomization study
Authors: Zhang Binbin , Liang Chen , Guo Shiwen
Published: September 2024

Background
Both intracranial aneurysms and aneurysmal subarachnoid hemorrhages are medical conditions characterized by high rates of mortality and disability. The research on the role of CD45 in cerebrovascular diseases is controversial, but the role of CD45 in intracranial aneurysms and aneurysmal subarachnoid hemorrhages is unknown. This study employs Mendelian randomization (MR) to rigorously test the causal impact of CD45 on these cerebral conditions.
Methods
We analyzed GWAS summary statistics for CD45 alongside data for both intracranial aneurysm and aneurysmal subarachnoid hemorrhage. Instrumental variables were carefully selected in alignment with MR standards. Our primary analysis method was inverse variance weighted (IVW), augmented by four alternative MR approaches to enrich the analysis. Comprehensive sensitivity tests were conducted to validate the robustness of our findings.
Results
Results from the IVW analysis suggested that a one-standard-deviation increase in CD45 levels is associated with a 19.6% increase in the risk of intracranial aneurysm and a 13.8% increase in the risk of aneurysmal subarachnoid hemorrhage (OR = 1.196, 95% CI: 1.038–1.379, P = 0.0136; OR = 1.138, 95% CI: 1.046–1.237, P = 0.0025 respectively). These results were consistent across additional MR methods. Sensitivity analyses reinforced the reliability of the findings, confirming no significant influence from pleiotropy or other biases.
Conclusion
Our findings substantiate a causal relationship between elevated CD45 levels and increased risks of intracranial aneurysm and aneurysmal subarachnoid hemorrhage. These insights suggest new avenues for therapeutic intervention, although further studies are needed to clarify the mechanisms involved.
All-complex optical field complete imaging scheme via weak measurement
Authors: Zhang Zhiyou , Liu Yurong , Zhu Junfan , Zhang Zhuoxin , Wang An , Jiang Yinghang , Wu Jiguo , Wang Yifan , Ye Ling , Zhang Jiaxuan , Liu Xiong , Ge Rongchun
Published: September 2024

The comprehensive recording of complex fields is essential for obtaining complete sample information. However, conventional imaging techniques only capture the amplitude information, resulting in the loss of phase part. Conventional phase-extraction schemes like optical spatial differential (OSD) and differential interference contrast (DIC), effective in pure phase scenarios, are not adequate for complex optical field imaging. Although deep learning-based techniques show promise in extracting phase information, the heavy reliance on computational resources limits their applicability. Therefore, we propose an adjustable weak measurement differential imaging scheme integrated into a microscope system (AWMD microscopy) using a planar differential element (DE) for fully record information from complex optical field. By implementing real and imaginary weak values, we introduce a phase-amplitude separation optical spatial differential (PAS-OSD) imaging mode to avoid cross-talk between amplitude and phase signals during imaging process. The technique allows rapid adjustment of differential properties for comprehensive optical field analysis and seamless switching between imaging modes (OSD, DIC, and PAS-OSD) to accommodate diverse scenarios. Additionally, the planar DE we proposed is broadband, easy to construct, and compatible with existing optical systems. We envision this technique driving advancements in optical imaging, biology, and precision inspection.
How AI Responds to Obstetric Ultrasound Questions and Analyzes and Explains Obstetric Ultrasound Reports: ChatGPT-3.5 vs. Microsoft Copilot in Bing
Authors: Du Yanran , Ji Chao , Xu Jiale , Wei Minyan , Ren Yunyun , Xia Shujun , Zhou JianQiao
Published: September 2024

Objectives: To evaluate and compare the accuracy and consistency of answers to obstetric ultrasound questions and analysis of obstetric ultrasound reports using publicly available ChatGPT-3.5 and Microsoft Copilot in Bing (Copilot).
Methods: Twenty questions related to obstetric ultrasound were answered and 110 obstetric ultrasound reports were analyzed by both ChatGPT-3.5 and Copilot, with each question and report being posed three times to them at different times. The accuracy and consistency of each response to twenty questions and each analysis result in the report were evaluated and compared.
Results: In answering twenty questions, ChatGPT-3.5 outperformed Copilot in both accuracy (95.0% vs. 80.0%) and consistency (90.0% vs. 75.0%). When analyzing obstetric ultrasound reports, two models performed similarly in accuracy and consistency, and can provide recommendations. The overall accuracy and consistency of ChatGPT-3.5 and Copilot were 83.86%, 87.30% vs 77.51%, 90.48%, respectively. However, in detecting abnormal amniotic fluid index, ChatGPT-3.5 was superior to Copilot (accuracy 87.50% vs. 66.67%, P < 0.05).
Conclusion: While ChatGPT-3.5 and Copilot can provide valuable explanations on obstetric ultrasound and interpret most obstetric ultrasound reports accurately, neither model consistently answered all questions correctly or with complete consistency, the supervision of physician is crucial in the use of these models.
New Evidence on Price Effects of Transparency Regulations in European Fuel Markets
Authors: Bernhardt Lea , Breiderhoff Xenia , Dewenter Ralf
Published: September 2024

This paper analyses the impact of transparency regulations on Super 95 and Diesel prices in Austria, France, and Germany to shed new light on the price effects of regulatory measures. To identify the effects of regulation, we use publicly available data from January 2005 to the end of December 2019 and estimate synthetic difference-in-difference models. Overall, we find little evidence of any significant price effects due to transparency regulations. In France, prices did not change significantly. In Austria, transparency regulations had a small but significant positive effect merely on Super 95 prices in the short run. In Germany, the Market Transparency Unit (MTU) had negative but small long-term effects on Diesel prices. Therefore, we conclude that the implemented transparency regulations in all three countries did not result in long-lasting lower prices, contrary to the desired outcome of the policy treatments.