bluuebunny/crossref_metadata_2025 huggingface dataset:
Environmental factors associated with Oncomelania hupensis lindoensis snails in a schistosomiasis-endemic area in Napu, Central Sulawesi
Authors: Koraag Meiske Elisabeth , Octaviani Octaviani , Massie Roy G. A. , Senewe Felly Philipus , Djohan Djohan
Published: September 2024

The presence of the freshwater snail Oncomelania hupensis lindoensis in their habitats is influenced by abiotic environmental factors (nutrients, water salinity, and predators) that play a crucial role in maintaining snail survival. The objective of this study is to determine the relationship between environmental factors and the presence of O. hupensis lindoensis snails in the Napu Valley, one of the Schistosomiasis-endemic areas in Indonesia. Eight environmental factors were measured in three different habitats: a seepage, a ditch, and a pond. The study found O. hupensis lindoensis snails in all three habitats, with significant differences in their numbers (p < 0.05). The seepage habitat had the highest snail density (762.22 snails per m2) compared to the other habitats. Phosphorus levels were highest in the seepage habitat compared to the other habitats, while nitrogen levels were highest in the pond habitat. Pearson correlation analysis found a significant positive correlation between O. hupensis lindoensis snails and water salinity in the ditch habitat (p < 0.05). In addition to environmental factors, the presence of snails can also be influenced by other factors, such as the presence of snail predators, the presence of snail nutrients, and the population of snail host niche competitors.
Assessment of process water quality (depending on the presence of process water systems) in car wash facilities across Germany and the Netherlands
Authors: Löffler Richard , Evers Holger , Beyer Andreas
Published: September 2024

There are around 2,500 car wash lines in Germany, consuming around 30 million m3 of drinking water per year. In view of the increasing scarcity of water, this level of consumption could soon be restricted by law, as it is in some countries. There are only a few systematic studies on process water systems in car wash lines in Middle Europe; we therefore carried out a survey to determine process water quality parameters (COD, turbidity, water hardness, pH, conductivity, dissolved O2, and temperature). Data were collected and analysed from 63 different locations in Germany and the Netherlands. In addition, longitudinal parameters were measured for 1 year at a single state-of-the-art site in Germany. The scatter of the observed values was quite considerable. The average COD in water of car wash sites with biological treatment was found to be significantly lower than in car wash sites working with filter treatment. Overall, the deviation of the pollution parameters was higher than expected. Surprisingly, there is hardly any reliable data on freshwater consumption in the car wash facilities. As most of the long-established facilities do not have a modern water treatment system, freshwater consumption is up to 300 L per car washed.
Mediatyzacja w kontekście pojęcia biografii i narracji - perspektywa historyczna
Authors: Ostrowski Marek Włodzimierz
Published: September 2024

Charakterystyczne dla współczesności procesy rozwoju mediów i ich wpływu na kulturę można określić mianem mediatyzacji. W artykule autor podejmuje próbę opisu tego postmodernistycznego stanu rzeczy, analizując zmiany w sposobie rozumienia pojęć ‘biografia’ i ‘narracja’.
A MULTIMODALIDADE EM LOJAS PARA FESTAS INFANTIS: ANÁLISE DO DISCURSO VISUAL E ESPACIAL
Authors: Fernandes Cláudia Regina Ponciano , Nascimento Maurício Silva do , Alves Ana Isabela Fernandes , Rocha Jandeilson Lira
Published: September 2024

Este artigo apresenta os resultados de uma pesquisa cujo objeto de estudo foi a multimodalidade em lojas de produtos para festas infantis. No contexto brasileiro, ainda existe uma concepção de texto arraigada ao verbal, necessitando promover uma leitura além do verbal, considerando essas lojas como textos. O objetivo foi investigar os significados e discursos sobre infância que são comunicados nesses textos espaciais. É uma pesquisa ancorada em Hodge e Kress (1988), Van Leeuwen (2005), Kress e Van Leeuwen (2001, 2006), Ravelli e McMurtrie (2016), entre outros. A pesquisa é de abordagem qualitativa e interpretativa, utilizando-se da pesquisa de campo como procedimentos de coleta de dados. Estes foram analisados pelas lentes da Gramática do Design Visual e da Análise do Discurso Espacial. Os resultados apontam discursos implícitos a favor de uma infância festiva, temática e consumista.
A meditação como recurso de tratamento do transtorno de ansiedade generalizada e suas interfaces com a neurociência
Authors: Gonçalves Lopes Rennan Márcio , Vaz de Paula Thalles , Siqueira de Moraes Mesquita Vitor
Published: September 2024

O Transtorno de Ansiedade Generalizada (TAG) é uma condição que envolve ansiedade e preocupação excessiva de maneira desproporcional em relação aos eventos ocorridos prejudicando a qualidade de vida do indivíduo. O objetivo desse artigo foi compreender como a prática de meditação pode ser um recurso de tratamento ao TAG. A metodologia utilizada foi pesquisa bibiográfica com abordagem acadêmica qualitativa. Após a leitura dos documentos científicos foi possível identificar dois tipos predominantes de Ansiedade - normal ou patológica. A última pode contribuir para o desenvolvimento do TAG, sendo o Brasil um país com uma taxa alarmante de casos. Recomenda-se como possibilidade de recurso de tratamento a Meditação. Conclui-se que a prática contínua da meditação pode ajudar no tratamento do TAG e ativa diversas áreas cerebrais aumentando o bem-estar e diminuindo a ansiedade patológica.
A economia solidária na integração de migrantes venezuelanos: reflexões de um caso em Pernambuco, Brasil.
Authors: Da Silva Bastos Antonio Fagner , Mello Gabriel Benício de , Da Silva Daniella Ramos da , Mello Sérgio Carvalho Benício de
Published: September 2024

Para dar alguma resposta aos venezuelanos que migraram recentemente ao país, o Governo do Brasil, dentre outras ações, interiorizou os migrantes para diversas localidades brasileiras. No entanto, a grande maioria não tendo expertise para acolhida de migrantes. Sem oportunidades no Mercado, e com dificuldades de receber apoio adequado do Estado, coube às instituições da sociedade civil auxiliar na acolhida e integração desses migrantes que acabam em situação de vulnerabilidade. Este artigo tem como objetivo descrever a experiência desenvolvida pela CBNE2 para integração econômica de migrantes venezuelanos através de práticas de viés solidário. Para tal, abordamos 10 histórias de migrantes empreendendo com o apoio de um fundo rotativo solidário e os analisamos sob a ótica dos vetores empreendedor e solidário propostos por Gaiger. Uma alternativa contra-hegemônica que apesar de não solucionar todos os problemas enfrentados, pôde dar melhores oportunidades aos recém-chegados.
“Eu quero ter uma vida!”: enfrentamentos interseccionais de sujeitos LGBTQIA+
Authors: Novais Barros Lucas , Silva Machado Veridiana , Castelar Marilda
Published: September 2024

Aparatos coloniais estigmatizam pessoas LGBTQIA+ a partir de diferentes posições, como raça, classe, gênero e sexualidade. Compreendendo tais opressões, urge a necessidade em articular estratégias que se articulem como enfrentamento subjetivo, político e social. Com isso, este trabalho tem como objetivo analisar estratégias de enfrentamento elaboradas e vividas por pessoas LGBTQIA+. Trata-se de uma pesquisa qualitativa e exploratória, com suporte da técnica do grupo focal e o uso do diário de campo. Foram realizados dois grupos focais entre 2021 e 2022, com 5 pessoas LGBTQIA+ diversas, onde discutimos vivências interseccionais, estratégias de enfrentamento e manifestações de nossas produções artísticas. Apresentamos duas categorias a partir dessas discussões, que trouxeram importantes reflexões sobre preconceitos e histórias de vida das pessoas participantes com as violências cotidianas, além das repercussões interseccionais (a partir de raça, gênero e sexualidade) dessas questões.
A metamorfose de corpos, sentimentos e cuidados: as diversas experiências de partos vaginais em mulheres de Rurópolis, Pará
Authors: Nascimento Dergan Joyce , Teixeira Cardoso Fernanda Jacqueline , do Nascimento Martins Nádia vicência , Aguiar da Silva Figueira Simone
Published: September 2024

O estudo em questão busca descrever as experiências de mulheres que passaram por partos vaginais em diferentes contextos hospitalares, especificamente em Rurópolis, Pará. Utilizando um método quantiqualitativo, foram realizadas entrevistas com 47 parturientes que tiveram partos normais em duas ou mais gestações, sendo o último parto realizado na Maternidade Municipal de Rurópolis. As respostas foram posteriormente submetidas à análise de conteúdo. Os resultados revelaram que as mulheres que deram à luz fora da Maternidade relataram uma maior incidência de intervenções médicas invasivas, maus tratos e violência verbal durante o trabalho de parto. Em contraste, as mulheres que receberam assistência na maternidade descreveram uma experiência mais positiva. Conclui-se a importância da ambiência e da presença de profissionais qualificados no processo de parturição, ressaltando a necessidade de implementar um modelo de assistência de boas práticas durante o trabalho de parto e parto.
Epitranscriptome: A Novel Regulatory Layer during Atherosclerosis Progression
Authors: Schiano Concetta , Trama Ugo , Coscioni Enrico , Infante Teresa , Coppola Annapaola , de Nigris Filomena , Napoli Claudio
Published: September 2024

RNA modifications have recently gained great attention due to their extensive
regulatory effects in a wide range of cellular networks and signaling pathways. In cardiovascular
diseases (CVDs), several RNA changes, called “epitranscriptome” alterations,
are found in all RNA molecules (tRNA, rRNA, mRNA, and ncRNAs). Unlike the epigenetic
process, which influences the progression of atherosclerosis (AS), its transcriptional
and post-transcriptional regulatory mechanisms are still unknown. Here, we described
the main epitranscriptome signs to provide new insights into AS, including m6A, m5C,
m1A, m7G, Ψ, and A-to-I editing. Moreover, we also included all current known RNA--
modifier-targeting, including small molecular inhibitors or activators, mainly designed
against m6A- and m5A-related enzymes, such as METTL3, FTO, and ALKBH5. Finally,
since only a few drugs, such as azacitidine and tazemetostat, targeting the DNA
epigenome, have been approved by the FDA, the next challenge would be to identify
molecules for targeting the RNA epitranscriptome. To date, total Panax notoginseng total
saponin could reduce vascular hyperplasia via Wilms’ tumor-associated protein-1
m6A-dependent. Indeed, a virtual screening allowed us to individuate a phytomolecule,
the rhein, which acts as an FTO inhibitor by increasing mRNA m6A levels. In this review,
we highlighted the RNA epitranscriptome pathways implicated in AS, describing
their biological functions and their connections to the disease. The identification of epitranscriptome-
sensitive pathways could provide novel opportunities to find predictive,
diagnostic, and prognostic biomarkers for precision medicine.
Beyond Conventional: Nanotechnology-Driven Herbal Interventions in the Treatment of Polycystic Ovary Syndrome
Authors: Roy Monalisa , Mazumder Rupa , Singh Neelam , Bhardwaj Snigdha , Mishra Rakhi , Mishra Rashmi , Kumar Bimlesh
Published: September 2024

Objective:

In patients with PCOS, oxidative stress is caused by an imbalance between
antioxidants and reactive oxygen species, which increases the risk of cardiovascular disease. Existing
therapies, which mostly include synthetic medications, often result in serious adverse effects.
Alternatively, a secure and efficient method of treating PCOS appears to be the mix of phytoconstituents
and lifestyle changes.

Methods:

This review examines the global impact of PCOS, a prevalent hormonal disorder combining
genetic, environmental, behavioral, and endocrine factors, and the potential side effects of
synthetic medications used for its treatment. The authors conducted a narrative review using major
databases like PubMed, ScienceDirect, and Google Scholar from October 1st to November
25th, 2023. They analyzed data from review articles, research articles, and meta-analyses published
until August 2023 on pathogenesis, diagnosis, management, synthetic and herbal treatment,
and nanotechnology effective in PCOS treatment, including those related to the theme.

Results:

PCOS affects women globally, and synthetic agents like insulin sensitizers, contraceptive
pills, and anti-androgens may have numerous long-term health effects. A natural substitute for contemporary
pharmaceuticals, herbal therapies are prized for their health benefits. Scientific studies
support the safety and effectiveness of herbal bio-actives, which utilize diverse phytochemicals to
reduce PCOS symptoms.

Conclusion:

To overcome the side effects of the synthetic agents, more influence is given to the
natural way of curbing the syndrome for a healthier life. Thus, this review combines the potential
advantages of utilizing various herbal plants for PCOS treatment by amalgamating findings from
numerous literature studies.
Effect of Chrysin and Chrysin Nanocrystals on Chlorpyrifos-Induced Dysfunction of the Hypothalamic-Pituitary-Testicular Axis in Rats
Authors: Farkhondeh Tahereh , Roshanravan Babak , Samini Fariborz , Samarghandian Saeed
Published: September 2024

Aims and Background:

The escalating global concerns regarding reproductive health underscore the urgency of investigating the impact of environmental pollutants on
fertility. This study aims to focus on Chlorpyrifos (CPF), a widely-used organophosphate insecticide, and explores its adverse influence on the
hypothalamic-pituitary-testicular axis in Wistar male rats. This study explores the potential protective effects of chrysin nanocrystal (CHN), a
flavonoid with known antioxidant and anti-inflammatory properties, against CPF-induced impairments in male Wistar rats.

Methods:

Chrysin nanocrystals were prepared using a solvent precipitation method. Six sets of male Wistar rats were subjected to 30 days of treatment,
comprising a control group, a group treated solely with CPF, groups treated with CHN at doses of 5 mg/kg and 10 mg/kg, and groups co-treated
with CPF and CHN. Serum levels of reproductive hormones, enzyme biomarkers of testicular function, oxidative stress, and inflammatory
biomarkers were assessed. Additionally, histological examinations were conducted on the hypothalamus, testes, and epididymis.

Results:

CHN exhibited antioxidant and anti-inflammatory properties, effectively counteracting CPF-induced reductions in Luteinizing Hormone (LH),
serum testosterone, Follicle-Stimulating Hormone (FSH), and testicular enzyme biomarkers. Moreover, CHN enhanced antioxidant defenses, as
evidenced by decreased malondialdehyde (MDA) and increased glutathione (GSH) levels in the hypothalamus, and testes, epididymis.
Inflammatory markers, including nitric oxide (NO), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α), were significantly reduced in
CHN co-treated groups compared to the CPF-only group. Histopathological analyses confirmed the protective effects of CHN on tissue integrity

Conclusion:

Chrysin nanocrystal demonstrated promising potential in mitigating CPF-induced reproductive deficits in male rats through its anti-inflammatory
and antioxidant properties. This study provides valuable insights into therapeutic interventions against environmental toxin-induced reproductive
toxicity, emphasizing the potential of chrysin nanocrystals as a protective agent in the context of CPF exposure
Liquid Crystalline Lipid Nanoparticles: Emerging Trends and Applications in Skin Cancer
Authors: Varshney Kamya , Mazumder Rupa , Rani Anjna , Pandey Pratibha , Ravindra babu Malakapogu
Published: September 2024

Liquid crystalline lipid nanoparticles (LCNPs) represent a type of membrane-based
nano-carriers formed through the self-assembly of lyotropic lipids. These lipids, such as unsaturated
monoglycerides, phospholipids, and co-lipids, create liquid crystals or vesicles with an aqueous
core enclosed by a natural or synthetic phospholipid bilayer upon exposure to an aqueous medium.
Liquid crystalline lipid nanoparticles (LCNPs), akin to liposomes, have garnered significant
attention as nanocarriers suitable for a diverse range of hydrophobic and hydrophilic molecules.
Their notable structural advantage lies in a mono-channel network organization and the presence
of multiple compartments, resulting in heightened encapsulation efficiency for various substances.
Cubosomes, spongosomes, hexosomes, and multicompartment nanoparticles are examples of lipid
nanocarriers with interior liquid crystalline structures that have recently gained a lot of interest as
effective drug delivery systems. Additionally, LCNPs facilitate the sustained release of encapsulated
compounds, including therapeutic macromolecules. This review delves into the structure of
liquid crystalline lipid nanoparticles, explores preparation techniques, and outlines their applications
in the context of skin cancer.
Eco Friendly Pharmaceutical Packaging
Authors: Shah Kamal , Singh Disha , Agrawal Rutvi , Garg Akash
Published: September 2024

Concerns over environmental contamination have been raised by the use of nonbiodegradable
and non-renewable materials such as glass, plastics, and metals in packaging applications.
With the goal of lessening the environmental impact of petroleum-based packaging materials,
an extensive amount of research has been conducted to find alternative packaging materials. Due to
their biodegradability, studies have shown that using bio-polymer-based materials can reduce the
amount of packaging waste produced, which could partially address the issue of trash disposal. This
review article is mainly focused on eco-friendly biodegradable material that can replace nonbiodegradable
pharmaceutical packaging material. These materials come from natural resources like
proteins, carbohydrates, etc. that have negligible to no negative effects on the environment and organisms
that depend on it. This article depicts how we can replace the existing non-biodegradable
plastics with eco-friendly material as the use of pharmaceutical packaging material also plays a crucial
role in the therapeutic performance of pharmaceutical products.
Role of Plant-derived Bioactive Compounds in Potential Snakebite Envenoming: A Review
Authors: Mohanraj Subramanian , Saravanakumar Arthanari , Periyasamy Parthiban , Kumar Chinnaiyan Santhosh , Vijayan Nivedha , Jambulingaeswaran Vinodha , Murugan Kokila
Published: September 2024

:

The issue of snakebite continues to be a distinctive matter of public health in various
regions across the globe, with a particular emphasis on India, where the ailment is widely prevalent.
Snakebites in the country disproportionately affect rural and indigenous populations, resulting
in some of the highest morbidity and mortality rates worldwide. Regrettably, in numerous
tropical nations, the accessibility of antivenom is frequently postponed or restricted, thereby
rendering antiserum the only targeted therapeutic alternative. Nevertheless, administering antiserum
in isolation does not provide adequate safeguard against the adverse effects of venomtriggered
hypersensitivity complications, which may be grave. Hence, this study aims to review
the plant-derived bioactive compounds used to treat snakebites in India. This review compiles
a list of medicinal plants and plant-derived bioactive compounds used in treating snakebites in
India, which were reviewed from the available literature in public databases (PubMed, Science
Direct, Springer, and Scopus). Search words used were 'bioactive compounds,' 'treatment for a
snakebite,' 'antivenom and snakebite,' 'Medicinal plants for snakebite, and 'composition of
snake venom'.

:

A list of 200 medicinal plants traditionally used in several countries for treating snake bites was
obtained. Based on scientific data, we reviewed only 83 medicinal plant extracts and bioactive
compounds obtained from various families, tested under in-vivo and in-vitro conditions to determine
their neutralization potency of snakebite envenomation. In this article, we have presented
a comprehensive review, judgmentally analyzed medicinal plants and their bioactive
compounds for their therapeutic potential against snake envenomation, and offer a thorough
discourse on diverse herbal plants employed globally for managing snakebites.
KOMPARASI KETAHANAN BANK SYARIAH DAN BANK KONVENSIONAL SELAMA PANDEMI COVID-19: ANALISIS INDEX BANKING CRISIS
Authors: Anisa Cindy Arzamitha  , Munawar Ismail
Published: September 2024

This study aims to compare the resilience of Islamic and conventional banking during the COVID-19 pandemic. Banking resilience is measured by the Banking Crisis Index (IBC) which is compiled using five components, namely Non Performing Loan (NPL)/Non Permorming Financing (NPL), Loan to Deposit Ratio (LDR)/ Financing to Deposit Ratio (FDR), Biaya Operasi Pendapatan Operasi (BOPO),  Capital Adequacy Ratio (CAR), dan Return on Assets   (ROA). The data used was obtained from monthly reports on Indonesian banking statistics from 2020-2022 which were then analyzed using a Mann Whitney U-Test. The result of this study indicate that there are significant differences in the resilience of islamic and conventional banking during COVID-19 with a significance value of 0,000>0,05.
MENGUNGKAP FAKTOR DETERMINAN PENGAMBILAN KEPUTUSAN KONSUMEN DALAM PEMBELIAN MAKANAN HALAL DI MAKASSAR
Authors: Aulia Fatimah Khairunnisa  , Aminnullah Achmad Muttaqin
Published: September 2024

The demand for halal food is increasing among Muslim consumers worldwide, including in Makassar. Halal awareness and certification influence purchasing decisions, as the halal label provides safety assurance for Muslim and non-Muslim consumers. Price perception also affects buying decisions, as affordable prices are desired. Income also plays a role in consumer buying patterns and preferences. This research aims to analyze the impact of halal awareness, halal certification, price perception, and income on purchasing halal food in Makassar. The study employs a quantitative approach, gathering data through questionnaires distributed to 153 respondents who are halal food consumers in Makassar and aged above 18 years. The collected data will be analyzed using Ordinal Logistic Regression analysis. The research findings reveal that halal awareness, halal certification, and price perception positively and significantly impact the purchasing decisions of Makassar consumers when buying halal food. On the other hand, income does not significantly influence the decision to purchase halal food.
PEMBIAYAAN BAGI HASIL: ANALISIS PENGARUH FAKTOR INTERNAL DAN FAKTOR EKSTERNAL BANK SYARIAH
Authors: Widawati Exvita , Wildana Muhammad Dandy Alif
Published: September 2024

The rapid development of the Islamic banking industry in Indonesia is evident in the substantial share of profit and loss sharing (PLS), particularly when compared to other nations. However, on regional scale, PLS as a primary product of Islamic banks has yet to assert dominance of disbursed financing. Analysis of internal and external factors that influence PLS of Islamic banks in Indonesia will be the focus of the research. The Error Correction Model method was chosen to determine the effects in the short and long term. Time series analysis was carried out in the time period January 2015 to December 2022. This research found that internal factors, Third-Party Funds had a positive and significant effect on PLS in the short and long term. Then Allowance for Impairment Losses in the short term does not have a significant effect but in the long term it has a negative and significant effect. Interestingly, PLS is not sensitive to CAR and economic growth. This research shows the resilience of Islamic banks in facing the crisis caused by the Covid-19 pandemic. PLS grew higher in the period after the Covid-19 Pandemic compared to before the Covid-19 Pandemic. The implications of these findings encourage Islamic banks to develop products and services, tighten risk management in the long term, and expand the market share of Islamic banks.
ANALISIS PENGARUH PENYALURAN ZIS TERHADAP PERTUMBUHAN EKONOMI INDONESIA TAHUN 2016 - 2021
Authors: Zaky Mu'ammar , Nurul Badriyah
Published: September 2024

This The objective of this research is to analyze the partial and simultaneous effects ZIS (zakat, infaq, and sadaqah) distribution, inflation, and exchange rate on economic growth in Indonesia during the 2016-2021 period. This quantitative study uses time-series secondary data during the span of 2016 to 2021, which was analyzed using multiple linear regression and classical assumption test. The results indicate that ZIS distribution, inflation, and exchange rate partially have positive and significant effects on economic growth in Indonesia and that they simultaneously have significant impacts on economic growth in Indonesia. Further, the adjusted R2 value demonstrates that the three variables above are able to explain Indonesia’s economic growth by 66.4%. The remaining 33.6% or 0.336 is explained by other variables not included in this research.
Keywords: multiple linear regression, inflation, exchange rate, zakat distribution, economic growth, time series
FAKTOR-FAKTOR YANG MEMENGARUHI KEPUTUSAN MENJADI INVESTOR BARU SAHAM SYARIAH
Authors: Umam Choirul , Aminullah Achmad Muttaqin
Published: September 2024

This study aims to find out what factors influence the decision to invest and become an investor in Islamic stocks during the Covid-19 pandemic. This study uses a quantitative approach with exploratory factor analysis method. The sampling method used was non-probability sampling with a purposive sampling technique with 105 samples obtained by distributing questionnaires to respondents who met the research criteria online. The results of this study reveal that there is an anomaly in new Islamic stock investors compared to old investors who tend to avoid investing during the Covid-19 pandemic. There are nine factors that influence the decision to invest and become new investors in Islamic stocks during the Covid-19 pandemic. These factors are technological advances, herding behavior, investment motivation, sharia compliance, risk perception, minimum investment capital, basic investment knowledge, avoiding speculation, and technical analysis factors.
IMPLEMENTASI PROGRAM PEMBERDAYAAN MASYARAKAT (PRODAMAS) DALAM PERCEPATAN PEMBANGUNAN INFRASTRUKTUR (STUDI KASUS KELURAHAN NGRONGGO KOTA KEDIRI)
Authors: Mochammad 'Ainurroziqin  , Susilo
Published: September 2024

Prodamas is a breakthrough program of the Kediri City Government in accelerating regional development through direct community participation (empowerment). Prodamas seeks to realize the ability and independence of the community in infrastructure development, community economic improvement, and social community. This research uses descriptive research with a qualitative approach which is limited by the research focus, namely (1) Implementation of the Community Empowerment Program (Prodamas) in Ngronggo Village, City District, Kediri City seen from Merilee S. Grindle's theory which contains policy content and implementation context; (2) Supporting and inhibiting factors for the implementation of Prodamas. The data analysis method uses the Interactive model according to Miles, Huberman, and Saldana (2014) with four stages, namely data collection, data condensation, data presentation, and conclusion drawing. The results showed that the implementation of the Community Empowerment Program (Prodamas) in Ngronggo Village, City District, Kediri City based on policy content and implementation context is in accordance with the theory of Grindle (2017), it's just that the desired degree of change has not been measured, then the resources used need development and adjustment. Supporting factors for the Prodamas program come from human resources, teaching, budget, facilities and infrastructure, and academics. Meanwhile, the inhibiting factors come from bureaucratization which is still complicated, human resources, and the fact that the Prodamas program is still ineffective.
Pengaruh Perceived Value, Brand Image, Dan Service Quality Terhadap Loyalitas Konsumen
Authors: Denelsky Clementhio , Hussein Ananda Sabil
Published: September 2024

The growth of the ice cream industry resulted in intense competition in the industry. This research was conducted with the aim of identifying the impact and relationship between perceived value, brand image, and service quality on consumer loyalty in Mixue. The writer is interested in examining the effect partially. This research is included in the category of explanatory research which aims to explain the causal relationship between the variables studied through hypothesis testing. The sampling method used is non-probability sampling using a purposive sampling method, in which respondents must be at least 17 years old and have purchased products at Mixue outlets in Malang City. Data analysis in this study was carried out using the SPSS 24 application (Statistical Package for the Social Sciences) to perform multiple linear regression testing.
 
Abstrak
Pertumbuhan industri es krim mengakibatkan ketatnya persaingan pada industri tersebut. Penelitian ini dilakukan dengan tujuan untuk mengidentifikasi dampak dan hubungan antara perceived value, brand image, dan service quality terhadap loyalitas konsumen di Mixue. Penulis tertarik untuk meneliti pengaruh secara parsial. Penelitian ini termasuk dalam kategori penelitian eksplanatori yang bertujuan menjelaskan hubungan sebab-akibat antara variabel yang diteliti melalui pengujian hipotesis. Metode sampling yang digunakan adalah non probability sampling dengan menggunakan metode purposive sampling, di mana responden harus berusia minimal 17 tahun dan pernah melakukan pembelian produk di gerai Mixue di Kota Malang. Analisis data dalam penelitian ini dilakukan menggunakan aplikasi SPSS 24 (Statistical Package for the Social Sciences) untuk melakukan pengujian regresi linear berganda.
Effect of Adding Jackfruit Dami (Artocarpus heterophyllus) on the Sensory and Chemical Characteristics of Red Dragon Fruit (Hylocereus polyrhizus) Fruit Leather
Authors:   Universitas Lampung, Putri Ananda Ericka , Murhadi Murhadi ,   Universitas Lampung, Herdiana Novita ,   Universitas Lampung, Hidayati Sri ,   Universitas Lampung
Published: September 2024

This research explores how the use of jackfruit mesocarp waste can improve the sensory and chemical aspects of red dragon fruit skin, considering the high pectin and fiber content in jackfruit dami, despite its lack of taste and color. Red dragon fruit is added to compensate for this deficiency. The research used a Completely Randomized Block Design with five comparisons of red dragon fruit and jackfruit dami: 100% : 0%, 75% : 25%, 50% : 50%, 2% : 75%, and 0% : 100%, each tested in five repetitions. The analysis carried out included testing data homogeneity with the Bartlett test, followed by the Tuckey range test, analysis of variance, and the Honest Significant Difference Test (HSD) at a significance level of 5%. This study concluded that the proportion of jackfruit dami significantly influences the sensory (texture, color, aroma, taste, and overall liking) and chemical properties (moisture content, ash content, acidity, vitamin C, and reducing sugars) of the fruit skin. The optimal composition found was a 50:50 mixture of dami jackfruit and red dragon fruit, which produced the desired sensory characteristics (a texture value of 3.87 indicated very elastic, a color value of 3.55 indicated a red color, an aroma value of 3.24 indicated favorable, taste value of 3.11, and overall preference rating of 3.60) and good chemical properties (moisture content 14.09%, ash content 0.88%, pH 4.26, vitamin C content 1.11 mg/g, and reducing sugar content 23.73%).
Anaplastični ependimom - rijedak uzrok hipertenzivnog hidrocefalusa u dojenčeta (prikaz slučaja)
Authors: Šarić Lea , Roganović Jelena
Published: September 2024

Cilj: Ukazati na nužnost pravodobnog prepoznavanja i adekvatnog zbrinjavanja hipertenzivnog hidrocefalusa - vitalno ugrožavajuće komplikacije u vidu hernijacije moždanih struktura, uz diferencijalno dijagnostičko razmišljanje u smjeru intrakranijskih novotvorina. Prikaz slučaja: Žensko dojenče od četiri mjeseca upućeno je na hitnu bolničku obradu zbog povećanja opsega glave uz kliničke znakove povišenog intrakranijskog tlaka. Fizikalnim pregledom uočen je hipertonus, pogled zalazećeg sunca, naglašen vaskularni crtež kranija i široko otvorena izbočena velika fontanela. Ultrazvuk mozga prikazao je hidrocefalus i ljevostranu tvorbu sa značajnim pomakom mozgovine (mass-efekt). Hitnim CT-om mozga verificirana je ljevostrana temporoparijetalna ekspanzivna tvorba dimenzija 100 x 62 x 74 mm (AP x LL x CC). Proširene komore, lijeva lateralna i treća komora bile su potisnute kontralateralno čime je nastala subfalcijalna hernijacija od 11 mm. Indicirano je hitno postavljanje vanjske drenaže likvora uz antiedematoznu terapiju (deksametazon, manitol). Pacijentica je hitno premještena u KBC Zagreb te je istog dana učinjena totalna ekstirpacija tumora. Histopatološkom pretragom postavljena je dijagnoza anaplastičnog ependimoma gradusa III. Poslijeoperacijski tijek bio je kompliciran trombozom transverzalnog i sigmoidnog sinusa te sindromom cerebralno uvjetovanog gubitka soli. Dva tjedna nakon učinjenog zahvata pacijentica je premještena u KBC Rijeka radi provođenja adjuvantne kemoterapije prema protokolu HIT 2000, bez odgađanja i težih nuspojava. Redovito je praćena putem dnevne bolnice. Osam godina nakon završenog liječenja djevojčica je u remisiji, urednog intelektualnog i tjelesnog razvoja. Zaključak: Anaplastični ependimom, iako rijedak u najranijoj životnoj dobi, treba razmotriti u diferencijalnoj dijagnozi povišenog intrakranijskog tlaka u dojenčeta. Pravodobnom dijagnozom, hitnom neurokirurškom intervencijom i odabirom optimalne poslijeoperacijske kemoterapije moguće je izlječenje uz minimalne neurološke sekvele.
Reinforcement Learning to Optimize Ventilator Settings for Patients on Invasive Mechanical Ventilation: Retrospective Study
Authors: Liu Siqi , Xu Qianyi , Xu Zhuoyang , Liu Zhuo , Sun Xingzhi , Xie Guotong , Feng Mengling , See Kay Choong
Published: September 2024

Background

One of the significant changes in intensive care medicine over the past 2 decades is the acknowledgment that improper mechanical ventilation settings substantially contribute to pulmonary injury in critically ill patients. Artificial intelligence (AI) solutions can optimize mechanical ventilation settings in intensive care units (ICUs) and improve patient outcomes. Specifically, machine learning algorithms can be trained on large datasets of patient information and mechanical ventilation settings. These algorithms can then predict patient responses to different ventilation strategies and suggest personalized ventilation settings for individual patients.

Objective

In this study, we aimed to design and evaluate an AI solution that could tailor an optimal ventilator strategy for each critically ill patient who requires mechanical ventilation.

Methods

We proposed a reinforcement learning–based AI solution using observational data from multiple ICUs in the United States. The primary outcome was hospital mortality. Secondary outcomes were the proportion of optimal oxygen saturation and the proportion of optimal mean arterial blood pressure. We trained our AI agent to recommend low, medium, and high levels of 3 ventilator settings—positive end-expiratory pressure, fraction of inspired oxygen, and ideal body weight–adjusted tidal volume—according to patients’ health conditions. We defined a policy as rules guiding ventilator setting changes given specific clinical scenarios. Off-policy evaluation metrics were applied to evaluate the AI policy.

Results

We studied 21,595 and 5105 patients’ ICU stays from the e-Intensive Care Unit Collaborative Research (eICU) and Medical Information Mart for Intensive Care IV (MIMIC-IV) databases, respectively. Using the learned AI policy, we estimated the hospital mortality rate (eICU 12.1%, SD 3.1%; MIMIC-IV 29.1%, SD 0.9%), the proportion of optimal oxygen saturation (eICU 58.7%, SD 4.7%; MIMIC-IV 49%, SD 1%), and the proportion of optimal mean arterial blood pressure (eICU 31.1%, SD 4.5%; MIMIC-IV 41.2%, SD 1%). Based on multiple quantitative and qualitative evaluation metrics, our proposed AI solution outperformed observed clinical practice.

Conclusions

Our study found that customizing ventilation settings for individual patients led to lower estimated hospital mortality rates compared to actual rates. This highlights the potential effectiveness of using reinforcement learning methodology to develop AI models that analyze complex clinical data for optimizing treatment parameters. Additionally, our findings suggest the integration of this model into a clinical decision support system for refining ventilation settings, supporting the need for prospective validation trials.
Strategies for Identifying and Recruiting Women at High Risk for Breast Cancer for Research Outside of Clinical Settings: Observational Study (Preprint)
Authors: Conley Claire C , Rodriguez Jennifer D , McIntyre McKenzie , Niell Bethany L , O'Neill Suzanne C , Vadaparampil Susan T
Published: September 2024

BACKGROUND

Research is needed to understand and address barriers to risk management for women at high (≥20% lifetime) risk for breast cancer, but recruiting this population for research studies is challenging.

OBJECTIVE

This paper compares a variety of recruitment strategies used for a cross-sectional, observational study of high-risk women.

METHODS

Eligible participants were assigned female at birth, aged 25-85 years, English-speaking, living in the United States, and at high risk for breast cancer as defined by the American College of Radiology. Individuals were excluded if they had a personal history of breast cancer, prior bilateral mastectomy, medical contraindications for magnetic resonance imaging, or were not up-to-date on screening mammography per American College of Radiology guidelines. Participants were recruited from August 2020 to January 2021 using the following mechanisms: targeted Facebook advertisements, Twitter posts, ResearchMatch (a web-based research recruitment database), community partner promotions, paper flyers, and community outreach events. Interested individuals were directed to a secure website with eligibility screening questions. Participants self-reported method of recruitment during the eligibility screening. For each recruitment strategy, we calculated the rate of eligible respondents and completed surveys, costs per eligible participant, and participant demographics.

RESULTS

We received 1566 unique responses to the eligibility screener. Participants most often reported recruitment via Facebook advertisements (724/1566, 46%) and ResearchMatch (646/1566, 41%). Community partner promotions resulted in the highest proportion of eligible respondents (24/46, 52%), while ResearchMatch had the lowest proportion of eligible respondents (73/646, 11%). Word of mouth was the most cost-effective recruitment strategy (US $4.66 per completed survey response) and paper flyers were the least cost-effective (US $1448.13 per completed survey response). The demographic characteristics of eligible respondents varied by recruitment strategy: Twitter posts and community outreach events resulted in the highest proportion of Hispanic or Latina women (1/4, 25% and 2/6, 33%, respectively), and community partner promotions resulted in the highest proportion of non-Hispanic Black women (4/24, 17%).

CONCLUSIONS

Although recruitment strategies varied in their yield of study participants, results overall support the feasibility of identifying and recruiting women at high risk for breast cancer outside of clinical settings. Researchers must balance the associated costs and participant yield of various recruitment strategies in planning future studies focused on high-risk women.
Allocative Efficiency Of Rice Farming Under Landscape Integrated Pest Management Program In Klaten District
Authors: Natriasukma Muhammad Pradipta , Hardyastuti Suhatmini , Irham
Published: September 2024

The research aims to (1) identify the factors that influence rice production of landscape IPM  and non-landscape IPM farming, (2) analyze the allocative efficiency of rice production factors use under landscape IPM and non-landscape IPM farming, (3) analyze the factors that influence rice farming income of landscape IPM and non-landscape IPM farming, and (4) analyze of IPM field school on the use of chemical pesticides. This research was conducted in December 2018 - July 2019. The basic method of this research was survey. The research location was in Klaten District as one of the landscape IPM program sites. The sample consisted of 30 landscape IPM rice farmers and 30 non-landscape IPM rice farmers who determined by simple random sampling. Data were analyzed by using multiple linear regression equation and Ordinary Least Square (OLS) method with Cobb-Douglas production function. The results  of the study are as follow: (1) farmers in Klaten District who applied the principle of landscape IPM had higher rice productivity and farm income, (2) the use of land size and seed on landscape IPM farmers and land use in landscape IPM has not been efficient so that it can still increase land size and seeds to increase rice production (3) increasing in seed prices and wages of hired labor can reduce rice farming income. Meanwhile, the expansion of land size can increase  rice farming income, (4) IPM field school has the effect of using fewer chemical pesticides by farmers.
PARTICIPATION OF SUBAK MEMBERS IN THE DEVELOPMENT OF FIELD ECOTOURISM IN TABANAN REGENCY, BALI
Authors: Yusnia Saras , Harsoyo  , Subejo
Published: September 2024

Subak group is a traditional organization in the field of water distribution and farming management in Bali. Mangesta Village is selected by UNESCO as on of the World Heritage Area. This research was conducted with the objectives of knowing: 1) Participation of subak members on the development of rice field ecotourism in mangesta village, penebel sub- district, tabanan regency, 2) Factors that influenced Participation of subak members on the development of rice field ecotourism in Mangesta village, Penebel sub-district, Tabanan regency. The method used in this research is descriptive analysis. Sampling group was done purposively based on hamlet that had field ecotourism, while the sampling of farmers as the respondents was done by simple random sampling. The total sample was 60 farmers as partof wongaya betan subak group. They where some members of the wongaya betan subak group. The analysis method used is the proportion and multiple linear regression analysis with Backward method. The research results showed that the Participation of subak memberson the development of rice field ecotourism in Mangesta village was categorized as moderate. Attitude, education, intensity following of extension, and gender have significant effect on participation. While age, main job, experience as farmer, and encouragement from community leaders have no significant effect on participation.
Advanced Treatment: Tackling Paracetamol with Fenton Oxidation and Membrane Hybrid Processes
Authors: Kamal Fadhila Malahayati , Laksono Sucipta , Adityosulindro Sandyanto
Published: September 2024

Paracetamol (PCT) in aquatic environments has become a global concern due to its potential harm to humans and environments. However, conventional water treatment was only able to degrade PCT partially. It was necessary to treat PCT contaminated water with tertiary technologies in particular by combination approach, such as Fenton oxidation and membrane filtration process. This combined approach enabling mitigation of large chemical footprint and iron residue associated with Fenton oxidation, as well as reducing fouling tendency of the membrane. The aim of this study was to evaluate the PCT removal efficiency by hybrid technology Fenton oxidation and membrane filtration. The membrane performance during the filtration process was also analyzed. As an important parameter for Fenton process, concentration of H 2 O 2 /Fe 2+ with ratio of 1:0.5 resulted in optimal removal of 45% PCT in terms of COD removal. However, separation using flat sheet Polyethersulfone Ultrafiltration (UF) with constant flux of 120 L/m²·h resulted in insignificant of COD removal. Nevertheless, the UF process was able to remove up to 54% of Fe 2+ at pH in alkaline condition with 8.5. In addition, a decrease in membrane permeability down to 0.2 L/m²h/bar over time, according to the filtered specific volume during the UF process, indicates fouling of the UF membrane during the 120 minutes of filtration. While the combined approach does not show significant improvement in COD removal, it does help to reduce the chemical footprint of the process, which is an important factor for the applicability of the selected water treatment method.
Digital Pedagogy Philosophy: Building Critical Awareness of The Role of Technology in Education
Authors: Fadli Muhammad Rijal
Published: September 2024

Technology integration in education raises the need for a philosophical foundation that guides the use of technology in learning contexts. The philosophy of digital pedagogy is an approach that provides an ethical basis and values that guide the application of technology in the educational process. This paper aims to explore the relationship between digital pedagogical philosophy, critical consciousness, and the role of technology in shaping contextual and adaptive learning experiences. This research uses a hermeneutic approach to describe the reality of Digital Pedagogical Philosophy in building critical awareness of the role of technology in education. This method involves elements of interpretation and description in analyzing and understanding the implications and significance of technology integration in the learning context. The philosophy of digital pedagogy provides a foundation for integrating technology into learning to support the formation of critical, creative, and responsible individuals. Critical awareness of the role of technology in education creates a deeper understanding of the challenges and opportunities faced in the digital environment. This approach can increase student interaction with course material, increase understanding of concepts, and promote critical thinking.
Entrusting Children to Grandmothers: Exploring Care Dynamics through Multiple Roles of Women in Eastern Indonesia
Authors: Ekawati Lenny Lia , Wijaya I Nyoman Indra Kresna , Delpada Benidiktus
Published: September 2024

This paper investigates the practice of entrusting children to relatives in Alor Tengah Utara, Alor Regency. It highlights the socio-economic factors compelling parents to work away from home. Often, this leads to parents leaving their children in the care of their grandparents. Despite the stagnant economic growth in Alor regency, many young individuals migrate in search of better opportunities, creating a dynamic where women, particularly grandmothers, become “double mothers” by caring for both their own and entrusted children. Conducted from June 2021 to July 2022, this ethnographic study reveals the challenges and economic vulnerabilities these households face, exacerbated by the inadequate intergenerational care provided by ageing grandmothers or inexperienced young female relatives. The findings highlight the need for more equitable caregiving arrangements and support for these families, shedding light on a practice deeply rooted in being a cultural responsibility yet fraught with economic and emotional complexities.