bluuebunny/crossref_metadata_2025 huggingface dataset:
Panel Veri Yöntemi ile Seçilmiş Ülke Ekonomilerinde Fosil Yakıt Talebinin İncelenmesi
Authors: Özbek Sefa
Published: March 2023

Bu çalışmada fosil yakıt talebinin belirleyicileri küreselleşme sürecinin derinleştiği güncel dönem verileri ile araştırılmaktadır. Panel veri yöntemlerinin kullanıldığı çalışmada yatay kesit birimleri olarak Arjantin, Bangladeş, Bulgaristan, Şili, Çin, Macaristan, Hindistan, Meksika, Pakistan, Peru, Filipinler, Polonya, Romanya, Tayland, Türkiye ve Ukrayna ekonomileri seçilmiştir. Adı geçen 16 ülkede 1990 yılında toplam enerji kaynakları içerisinde fosil yakıtların payı %75.47 iken 2018 yılında %84.23 oranında gerçekleşmiştir. İlgili ülke ekonomilerinde 1990 yılına göre 2018 yılında toplam enerji ithalatı %388.96 artış göstermiş ve bu artışın önemli bölümü fosil yakıt tüketiminden kaynaklanmaktadır. Bu durum gerek cari açık gerekse çevresel kalite açısından önemli sorunları meydana getirebilmektedir. Bu çalışmada 1990-2018 örneklem dönemine ait fosil yakıt talebi ile ekonomik büyüme, doğrudan yabancı yatırımlar, reel enerji fiyatları, karbondioksit emisyonu, kentleşme ve enerji kayıpları arasındaki kısa ve uzun dönemli ilişki ampirik olarak incelenmektedir. Panel veri analizi yöntemlerinden Havuzlanmış Ortalama Grup (PMG), Ortalama Grup (MG) ve Dinamik Sabit Etkiler (DFE) tahmincilerinin kullanıldığı çalışmada model tercihi için Hausman testi yapılmaktadır. Ampirik bulgular ekonomik büyüme, reel enerji fiyatları, doğrudan yabancı yatırımlar ve kentleşmenin fosil yakıt talebini düşürdüğünü; karbondioksit emisyonu ve enerji kayıplarının ise fosil yakıt talebini artırıcı rol oynadığını göstermiştir.
Anahtar Kelimeler: Fosil Yakıt Kullanımı, Ekonomik Büyüme, Enerji Kayıpları, Enerji İthalatçısı Ülkeler.
JEL Sınıflandırması: O13, F43.
Çocuklarda Vergi Algısına Yönelik Kırıkkale İlköğretim Öğrencileri Üzerine Bir İnceleme
Authors: Güngüneş Sabriye Nur , Uğur Alparslan
Published: March 2023

Vergilemede başarının sağlanmasında sosyal ve psikolojik faktörlerin önemi göz ardı edilemeyecek düzeydedir. Özellikle küçük yaşlardan itibaren vergi bilinci oluşturularak vergiye gönüllü uyumun sağlanması önem arz eder. Küçük yaşlarda kazanılan vergi bilinci sonraki yıllarda vergi ödeme alışkanlıklarını etkilemektedir. Çalışmamızda Kırıkkale ilinde ikamet eden ve 4., 5. ve 6. sınıfta eğitim gören 9-11 yaş grubundaki öğrencilerin vergi bilincini tespit etmek için anket çalışması uygulanmıştır. 3 devlet ve 1 özel okulda yapılan çalışmada öğrencilere 30 adet soru sorulmuştur. Ankette demografik değişkenler, vergi bilinci ve fiş-fatura bilinci gibi kavramlar sorgulanmıştır. Öğrencilerde vergi bilincinin oluşumu noktasında en önemli faktörün aile ve eğitim olduğu sonucuna ulaşılmıştır. Günümüzde vergi bilinci internet sayfasının oluşturulması, her yıl düzenli olarak vergi haftasının kutlanması, görsel hafızaya hitap edecek şekilde afişlerin tasarlanması ve ders kitabı içeriklerinin üretilmesi gibi çocuklarda vergi bilincinin oluşturulması amacıyla yapılmış çalışmalar bulunmaktadır. Çalışma sonucunda öğrencilerde vergi bilincinin artırılması için yapılması gereken alternatif öneriler sıralanmıştır.
Anahtar Kelimeler: Vergi, Vergi Bilinci, Çocuklarda Vergi Algısı
JEL Sınıflandırması: H20
Neuropsychological and Neurolinguistic Foundations of Speech Activation in the Educational Process
Authors: Tieliezhkina Olesia , Naumenko Liana , Zhyglo Oksana , Palasevych Iryna , Babkina Маiya , Voloshyn Mariia
Published: March 2023

The main purpose of the study is to analyze the neuropsychological and neurolinguistic foundations of speech activation in the educational process. Human speech activity is closely connected with all spheres of human consciousness. The history of the existence of mankind has proved that it is speech that is an important factor in the mental development of the individual and the improvement of social relations. Under the influence of speech, consciousness, mental operations, volitional and emotional spheres develop, and the intellectual capabilities of a person are enriched. Broadcasting as a psychological phenomenon is one of the most difficult in the life of each of us. Speech activity has its own physiological mechanisms, which are determined not only at the functional, but also at the morphological level. Based on the results of the study, key aspects of the neuropsychological and neurolinguistic foundations of speech activation in the educational process were considered.
Psychological and Pedagogical Technologies in Working with Children with Special Educational Needs: Neuropedagogical Aspect
Authors: Lyndina Yevheniia , Martynyuk Zoriana , Tovstohan Volodymyr , Babichenko Alona , Mytsyk Hanna , Samoilenko Inna
Published: March 2023

The topic of the article is relevant, as the education of children with special needs (OOP) is one of the most pressing and debatable problems of modern education today. The issue of education of children with disabilities becomes relevant due to the significant increase in the number of this group in society, on the one hand, and emerging new opportunities for their adaptation in society, on the other hand. The purpose of the article is to study the functioning system of special education support centers in working with children with special educational needs; familiarization with requirements for psychological and educational support for the development of a child with disabilities; psychological and pedagogical neurotechnologies in working with children with special educational needs; presentation of effective psychological and pedagogical technologies in working with children with special educational needs. As a social group of society, the children must first of all receive real conditions for obtaining quality education, starting from school, and then for obtaining professional training with further employment and adaptation in society. Changes in the school education system could affect only the content of corrective and developmental education for children with disabilities.
New Physical and Neurophysiological Rehabilitation Programmes for Women of Childbearing Age
Authors: Honcharuk Nataliia , Tamozhanska Ganna , Korytko Zoryana , Rusyn Ljudmyla , Vasylieva Nataliia , Adamenko Oksana , Maksymchuk Borys
Published: March 2023

The article describes physical and neurophysiological rehabilitation of women of childbearing age with extragenital pathology, the most common oncologic pathologies of female genitalia. The article aims to develop a programme of physical and neurophysiological rehabilitation for women of childbearing age with extragenital pathology who underwent ovariectomy and evaluate its effectiveness. The authors observed 100 women aged between 18 and 45: the control group (CG) - 50 women and the experimental group (EG) - 50 women; each group was also divided into two age sub-groups - 18-29 years old and 30-45 years old. The exercise therapy included physical and neurostimulation rehabilitation measures: calisthenic routine, static and dynamic breathing exercises, shallow breathing, some elements of muscle relaxation and autogenic training, dosed walking inside the ward, going up the stairs, as well as dosed walking using treadmills, pelvic floor exercises. Methods of studying rehabilitation effectiveness are the following: instrumental methods (heart rate monitoring; arterial tonometry; respiratory rate measuring; spirometry); functional tests (hypoxic Stange and Genchi tests; orthostatic tests; clinostatic tests); laboratory research methods (clinical blood tests). The article proves that the employed methods of physical rehabilitation helped to increase indicators of the cardiovascular and respiratory systems in EG patients aged between 18 and 29 3-5 days earlier and EG patients aged between 30 and 45 - 3-4 days earlier than that in CG. It proves the effectiveness of the developed programme of physical rehabilitation for women of childbearing age with extragenital pathology who underwent ovariectomy.
Antinomicity of the Good-Truth-Beauty Triad on the Internet
Authors: Onyshchuk Oksana V. , Pankiv Olesia V. , Sinelnikova Maria V.
Published: March 2023

The presented article outlines vectors of transformation of basic values of Good-Truth-Beauty in the network. The epistemological, moral-ethical, and aesthetic aspects are offered, which allows revealing the forms of representation of initial values in the Internet culture. In particular, the planes of the intersection of the axes “good/evil”, “truth/lie”, and “beautiful/ugly” in social media are presented. The authors are concerned about the assertion of equivalence and blurring of the boundaries between good and evil, which can lead to permissiveness that is covered by anonymity, symbolism, and nominalisation provided by social networks. The article explores the articulation of the problem of evil in the Internet through the use of the heuristic potential of aesthetic experience. An analysis of modern aesthetic forms of the representation of evil in network culture through the prism of such basic values as Goodness-Truth-Beauty is carried out. It is shown how these values are deformed and sometimes turn into their opposite with the help of aesthetic means. It is shown that modern propaganda, which is carried out in social networks, actively uses existential features of perception and experience of truth. In the course of the study, the opinion is substantiated that reflexive judgment allows to attract aesthetic means to the moral understanding of manifestations of evil in the absence of stable standards and moral guidelines in social networks.
Technologies as a Mediator between Creator and Audience in Postmodern Art Practices
Authors: Kharchenko Polina , Chibalashvili Asmati , Savchuk Igor , Sydorenko Victor , Khasanova Іvetta
Published: March 2023

The article analyzes the interaction between creator and audience that occurs in the new modes of art practices. Within this field, experimenting with technology is accompanied by emergence of new art forms and genres. Thus, it seems appropriate to view technologies as a mediator in the dynamic process of communication between the creator and viewer. In this context, a number of innovative projects were considered that emerged in the art practices of the recent decades. The choice of the projects is determined by the specific expressive means and by the features of interaction of these means on the basis of contemporary technologies. Creation of these projects resulted from the ideas and achievements of the 1970s–1990s. At first, it was "pure" experimentation, aimed at expanding the range of new expressive components and testing them. Afterwards, modern art products created within this direction are mature and complete. To evoke the interest of the audience, the use of multimedia and installations based on interactive technologies are employed. Technologies stimulate further evolution of art, i.e. they contribute to forming the new genres, and trends. It was concluded that technologies constitute a toolkit that de facto serves as a catalyst enabling practical realization of the artistic polylogue within the creative process: from the point when the idea is conceived, through its fulfillment in the creator’s design and up to its presentation when its communicative models of influence aimed at the art communities are activated.
Network Planning at the Faculties of Physical Education and Sport in the Postmodern Era
Authors: Popel Serg , Mazin Vasyl , Maksymchuk Borys , Saienko Volodymyr , Chernyshenko Tamara , Maksymchuk Iryna
Published: March 2023

The article aims to study the issues of university teachers and students from the faculties of physical education and sport to improve the educational process based on the principles of network planning. The article presents the results of the sociological questioning of the subjects of the educational process of physical education and sport faculties about the problems in the organization and planning of effective learning, as well as appropriate optimizing recommendations. A subject correlation matrix has been developed in the furtherance of this goal, in which each subject has a specific line and column. The analysis of the subjects’ matrix allows one to pre-determine the order of study of individual subjects in courses and cycles, their relationship and interframe sequence. Within the framework of the experiment, the authors of the article have surveyed 52 university teachers and 450 physical education students. The survey included questions relating to personal opinions about the advantages and disadvantages of the new curriculum and relevant programmes in 16 major subjects. Statistical data processing was carried out using the SPSS Statistics 17.0 software package. The recommended concentrated arrangement of the leading subjects of the biomedical cycle will allow one to create an interdisciplinary programme giving a complete vision of the structure, functions and biochemical processes occurring in various human body systems.
Bilgi-İktidar İlişkisi Çerçevesinde Akademide Kariyer ve Verimlilik Söylemi Üzerine Niteliksel Bir Değerlendirme
Authors: BAL Sevil
Published: March 2023

Türkiye’de 1980’lerden bu yana etkili olan neo-liberal politikalar; üniversite ve akademinin yapı, koşul ve işleyişinde iktisadi, politik ve sosyo-kültürel dönüşümü beraberinde getirmiştir. Piyasanın talepleriyle uzlaşan “verimlilik stratejileri”, “girişimcilik kültürü”, “kalite standartları”, “performans kriterleri” gibi faktörler; arz-talep ilişkisi çerçevesinde konumlandırılmakta, serbest pazar ekonomisi ve özelleştirme vurgularıyla akademide meşruiyet kazanmakta ve yeniden üretilmektedir. Bu nedenle neo-liberal ilişkilerin doğallaştığı, eleştirel söylem ve üretim süreçlerinin “marjinal” olarak değerlendirildiği bir kurum-mekân ve bir pratik-işleyiş olarak akademinin her alanında yer bulan meşru bilgi-iktidar ilişkilerini tartışmaya açmak önem kazanmaktadır. Özgür düşünce toplulukları olarak, özgün koşullarını eleştirel sorgulama, araştırma ve bilimsel özerklik söylemi ekseninde oluşturan akademiye dönük özdüşünümsel bakış açısına da bu kapsamda ihtiyaç duyulmaktadır. Kapitalizmin kariyer-verimlilik yaklaşımı yoluyla öğretim üyeleri/elemanları üzerinde örtük olarak kurulan iktidar biçimlerinin üniversitelerde nasıl oluştuğunu ve yeniden üretildiğini inceleyen bu çalışma, araştırma görevlilerinin, bilgi-iktidar ilişkisi bağlamında, akademik kariyer ve akademik verimlilik konusundaki değerlendirmelerine yönelik niteliksel bir inceleme sunmayı amaçlamaktadır. Bu kapsamda belirlenen devlet ve vakıf üniversitelerinde farklı demografik özellikler, çalışma koşulları ve deneyime sahip 12 araştırma görevlisi ile niteliksel araştırma yöntemi kapsamında yarı-yapılandırılmış mülakatlar gerçekleştirilmiştir. Elde edilen bulgular, kariyer ve verimlilik söyleminin, öznede içkin akademik deneyimlerden, üniversitedeki çalışma pratiklerine ve neo-liberal yapısal koşullara uzanan çoklu bir iktidar kavrayışıyla birlikte değerlendirilmesi gerektiğini gösteriyor.
Comparative Phytochemical Profiling of Psophocarpus tetragonolobus (L.) D.C. Seed Extracts for Effective Storage of Cowpea Seeds
Authors: Kavitha S. , Renugadevi J. , Renganayaki P.R. , Suganthy M. , Meenakshi P. , Raja K. , Madhan K.
Published: March 2023

Background: Winged bean (Psophocarpus tetragonolobus (L.) D.C.), is unique legume which has numerous phytochemical with distinct properties. So, this research work was performed to explore and quantify the bioactive compound from different extracts of winged bean seeds through GC-MS and to assess the bio-efficacy on cowpea seed to protect them against deterioration and bruchid. Methods: The bioactive compounds of winged bean seed extracts (from different solvents, viz., water, ethanol and hexane) were analysed by GC-MS and the bio-efficacy of identified superlative extract on maintaining the quality of cowpea seed var. VBN 3 was done using accelerated ageing method. Result: The GC-MS results showed the attendance of 30 different compounds in different extracts of the winged bean seeds. Of the different compounds eluted from extract, the ethanolic seed extract revealed the existence of distinct phytocompounds such as d-mannitol,1,4-anhydro-(1.59%), diethyl phthalate (27.21%), n-hexadecanoic acid (4.54%), 9,12-octadecadienoic acid (Z,Z)- (9.71%), oleic acid (14.16%), octadecanoic acid (4.89%), 9,12,15-octadecatrienoic acid and 2-phenyl-1,3-dioxan-5-yl ester (1.05%) which possess significant antioxidant and insecticidal properties. Among the different concentration of ethanolic extract, cowpea seeds treated with 2.5% of ethanolic seed extract of winged bean showed the highest germination (94%) and vigour index I (4436) compared to other treatments while the control recorded lowest germination (88%) and vigour index (3572) at initial day. As ageing progresses, seed germination percent and vigour index of 2.5% ethanolic extract treated seeds dropped to 63% and 1845 while, it is 42% and 953 in case of untreated seeds. The bio-efficacy study of ethanolic extract against bruchid revealed the LD90 value (2.5%) of winged bean seed extract. This study clearly shows that ethanolic extract of winged bean seeds have many bioactive compounds with distinct properties that maintain the seed quality under storage.
Impact of highway design on traffic safety: How geometric elements affect accident risk
Authors: Garnaik Mohita Mohan , Giri Jyoti Prakash , Panda Arnapurna
Published: March 2023

The study conducted in India using Fuzzy Inference System (FIS) is a novel approach to predicting traffic accident rates on rural highways. By using various highway geometric elements as input data, the study was able to identify risk variables related to roadway features and predict accident rates using FIS. The findings of the study suggest that FIS is a valuable tool for predicting accident rates and can help identify the factors that contribute to accidents. The study also found statistically significant positive connections between geometric elements and accident rates, which highlights the importance of highway design and safety measures. The use of Fuzzy Inference Systems in accident prediction is a promising approach as it allows for a more comprehensive understanding of the complex relationships between various factors contributing to accidents. The model was tested using simulation and data analysis and was found to fit well with real-world data, indicating its potential for practical applications in road safety management. Overall, this study provides important insights into the use of FIS in predicting accident rates on rural highways and can help guide future research in this area. It also highlights the importance of considering various highway geometric elements in designing safer highways and implementing appropriate safety measures to reduce accident rates. However, the road accidents can have significant impacts on ecological cycles, including habitat fragmentation, wildlife mortality, pollution, and climate change.
Possibilities and challenges for landscape observatories
Authors: Ternell Anna , Lagerquist Bosse , Nilsson Anders M. , Klie Mauricio Sagastuy , Berg Martin , Pedersen Martin Andre Bae , Némethy Sándor , Horváth Ágnes , Bene Zsuzsanna , Oláh Csaba , Bánné Gál Boglárka , Molnár Gábor , Remenyik Bulcsú
Published: March 2023

The twentieth century saw rapid environmental degradation due to changes that contributed to increased net GHG emissions, loss of natural ecosystems, and declining biodiversity. Deterioration of unprotected landscapes during swift industrialization, urbanization, increasing monocultures in agriculture, expansion of commercial production significantly contributed to these negative consequences. However, a cultural shift occurred during the last two decades in favour of landscape conservation. In response to widespread landscape degradation and loss of ecosystem services, the Council of Europe saw the need to protect, manage, and develop the landscapes, and thus signed the European Landscape Convention (ELC) in 2000. This was the world's first international agreement that described all aspects of landscape management in detail. The European Landscape Convention fully meets the challenges through its goal of correcting a lack of understanding of landscapes as a unique system embracing natural, economic, and social features throughout Europe. It goes beyond simply protecting landscapes and addresses landscape management and development, as well as raising public and government awareness of the importance of paying attention to all types of landscapes, whether exceptional or spoiled. Landscape observatories, multifunctional platforms and knowledge centres for researchers, technicians, administrators, and citizens, are one of the Council of Europe's instruments for implementing the European Landscape Convention (ELC). They can be established on a variety of scales and can serve as a vital link between administrations, civil society, researchers, and the economic sector. This article discusses the emergence of landscape observatories and the role they can play as decision support instruments in promoting sustainable landscape development through a regenerative approach. Additionally, the paper discusses the implementation of ELC in Västra Götaland in Sweden through the establishment of Landscape Observatory Västra Götaland, and its impacts and challenges associated with landscape development. Furthermore, we propose a comprehensive and holistic, to any landscape type adaptable landscape observatory concept, based on multifunctionality of these institutions, emphasizing their decision support roles, social and economic importance.
How Might the National Revenue Authority of Sierra Leone Enhance Revenue Collection by Taxing High Net Worth Individuals?
Authors: Kangave Jalia , Occhiali Giovanni , Kamara Ishmail
Published: March 2023

In the wake of the Covid-19 pandemic, increasing domestic revenue mobilisation has become even more of a priority for low-income countries. One of the commonly untapped sources of revenue across many of these countries are high net worth individuals, who usually manage to avoid contributing their fair share of taxes. This is also the case in Sierra Leone, which signalled its intention to develop a strategy to increase compliance of this taxpayer segment in 2019. In this paper we provide an initial assessment of how fit for purpose the current legal setting is, as well as give a general picture of the most likely characteristics of high net worth individuals in the country. Our analysis is based on semi structured interviews with stakeholders from both the public and private sector, and currently available administrative data, and provides a series of suggestions for next steps in the development of a dedicated strategy.
PEMBERIAN KOMISI DALAM PENYITAAN SEPEDA MOTOR LEASING SEPIHAK YANG MEMAKAI JASA DEBT COLECTOR
Authors: Saputra Dwi dicki , Fauziah Fauziah , Lubis Ramiah
Published: March 2023

ABSTRAK
Hasil penelitian yang didapat dalam penelitian ini sistem Pemberian komisi bagi Debt Collector dalam penyitaan sepeda motor leasing sepihak pada PT. Adira Dinamika Multi Finance, Tbk Palembang. yaitu apabila nasabah membayar uang tunggakan kredit sepeda motor, maka debt collector akan diberi komisi sebesar 10% dari uang yang dibayar oleh nasabah, dan apabila debt collector menarik kembali kendaraan sepeda motor nasabah yang sudah jatuh tempo maka debt collector akan diberi komisi sesuai jenis, keadaaan serta tahun dikeluarkannya sepeda motor tersebut pandangan Hukum Ekonomi Syariah terhadap pemberian komisi kepada debt collector dalam penyitaan sepeda motor leasing sepihak PT. Adira Dinamika Multi Finance, Tbk Palembang. Didalam Al- Qur‟an tidak dijelaskan tentang seberapa kita harus membayar komisi, akan tetapi harus diliat dari kondisi perekonomian sekarang sebaiknya komisi yang diberikan kepada Debt collector tersebut harus 50% dikarenakan resiko dari pekerjaan tersebut sangat lah berat. Jenis penelitian ini merupakan Field research dengan studi yang dilakukan di lokasi penelitian.
 
Kata kunci: Pemberian komisi kepada Debt Collector, Dalam Hukum Ekonomi Syariah.
Colpocleisis in the surgical treatment of pelvic organ prolapse: clinical experience
Authors: ÖZÇELTİK Gökay
Published: March 2023

Aim: The objective of this study was to present the clinical experience with colpocleisis by evaluating patient characteristics and long-term follow-up data.
Materials and Methods: This is a retrospective cohort study evaluating patients who underwent obliterative surgery for pelvic organ prolapse (POP) between 2010 and 2017. Patients who underwent
colpocleisis without hysterectomy (C) (n=68) and colpocleisis of vaginal vault (CVV) (n=22) were included in this study.
Results: The mean age of the study population was 72.7 years (range 55-89). The majority of the patients underwent colpocleisis as their primary surgical procedure for POP, as only 5.6% of the study group had a history of previous prolapse surgery. The mean follow-up duration was 49.5 months (range 1.5-109). Patient satisfaction with the surgery was high, with 98.9% of patients expressing they were “very satisfied” and 1.1% “satisfied”. There were two cases of recurrence (2.2%), and both were in the C group. One patient (1.1%) reported regret after surgery due to her husband's remorse about choosing an obliterative procedure. The recurrence rates, patient satisfaction, and regret were comparable between C and CVV groups.
Conclusion: Colpocleisis is a viable option for the surgical treatment of POP, offering a high rate of success and patient satisfaction in long-term. Despite being an obliterative procedure, colpocleisis has acceptance as the primary surgical procedure by patients regardless of their marital status, and regret rate after surgery is low. Therefore, colpocleisis should be thoroughly discussed and included in the preoperative counseling and surgical planning of all patients with POP.
The role of intraoperative neuromonitoring in thyroid surgery training
Authors: ÜSTÜN Mehmet , TUNCER Korhan , AKPINAR Göksever , SAĞLAM Buğra , GÜLER Necdet , MAKAY Özer
Published: March 2023

Aim: Intraoperative nerve monitoring (IONM) during thyroid surgery has been widely accepted as an additive improvement to the gold standard of visually identifying the RLN. This study aims to evaluate the role of IONM application in thyroid surgery education during general surgery residency.
Materials and Methods: Patients who underwent total thyroidectomy between January 2012 and December 2019 were included in the study. The patients were divided into 2 groups according to the use of IONM (Group 1: With IONM, Group 2: Without IONM). These groups were also divided into subgroups as assistants and experts among themselves.
Results: This study involved 256 patients. There were 116 patients in group 1, and 140 patients in group 2. Histologic analysis results revealed that IONM was used more frequently in patients with a
malignancy (p=0.015). The median operative time was significantly longer when IONM was used, with an operative time of 130 minutes for group 1 and 120 minutes for group 2 (p=0.015). When Group 1B and Group 2B were compared among themselves, the median operation time in Group 1B was 130 minutes, and the median operation time in Group 2B was 125 minutes (p=0.026). In the comparison between Groups 1B and 2B, it was detected that the rate of use of IONM was higher in malignancies
(p=0.025).
Conclusion: According to our results, the use of IONM did not reduce the incidence of RLN paralysis in thyroidectomy performed by specialists and residents.
Endometrium karsinomlarında immünohistokimyasal olarak yanlış-eşleşme onarım (MMR) protein ekspresyonunun prognostik parametreler ile ilişkisinin araştırılması
Authors: SERİN Gürdeniz , SAVAŞ Pınar , ÖZDEMİR Necmettin , ZEKİOĞLU Osman , AKMAN Levent
Published: March 2023

Amaç: Endometrium karsinomlarında son yıllardaki en önemli gelişme moleküler sınıflama olmuştur. Bu sınıflamada tümörler dört gruba ayrılmıştır: 1-POLE mutant grup, 2-Mikrosatellit instabil (MSİ) grup, 3-Yüksek kopya sayısı grubu (P53 mutasyonu), 4-Düşük kopya sayısı grubu. Bu gruplardan POLE ve MSİ grup daha iyi prognoza sahip olması ve immün-kontrol inhibitör tedavisinden fayda görebilme potansiyelleri ile öne çıkmaktadır. Çalışmamızda immünohistokimyasal (İHK) yöntemle MMR proteinlerinde (MLH-1, PMS-2, MSH-2,
MSH-6) nükleer ekspresyon kaybı olan ve olmayan olguların prognostik paramaterelerinin karşılaştırılması amaçlanmıştır.
Gereç ve Yöntem: Bölümümüzde 2017-2020 yılları arasında histerektomi materyalinde endometrium karsinomu tanısı almış ve İHK olarak MMR proteinlerinin değerlendirildiği 80 hasta çalışmaya
alınmıştır. MMR kaybı olan ve olmayan olgular tümör boyutu, histolojik derece (HD), myometrial invazyon derinliği, lenfovasküler invazyon (LVİ) ve servikal tutulum açısından karşılaştırılmıştır.
Bulgular: Olguların 37’sinde (%46,3) MMR proteinlerinin herhangi birinde kayıp mevcutken, 43’ünde (%53,7) kayıp izlenmemiştir. MMR protein nükleer ekspresyon kaybı açısından olgular
karşılaştırıldığında, kayıp saptanan olguların %45,9'da (17/37), kayıp saptanmayan olguların ise %27,9'da (12/43) histolojik derece III'tü (p:0,03). Myometrium 1/2 dış invazyon, servikal stromal tutulum ve LVİ açısından iki grup arasında istatistiksel olarak anlamlı bir fark saptanmamıştır.
Sonuç: Çalışmamızdaki olguların yaklaşık yarısında MMR proteinlerinin en az birinde kayıp saptanmıştır. En sık kayıp MLH-1 ve PMS-2 kaybı olarak ortaya çıkmıştır. MMR proteinlerinde nükleer
ekspresyon kaybı izlenen olguların HD’si kayıp saptanmayan olgulara göre istatistiksel olarak anlamlı şekilde daha yüksek olma eğilimindedir.
Primary autoimmune thrombocytopenia in pregnancy: maternal and neonatal outcomes
Authors: EKİCİ Hüseyin , ÖKMEN Fırat , SARITAŞ Didem Gül , İMAMOĞLU Metehan , EKER Turnagül , ERGENOĞLU Ahmet Mete
Published: March 2023

Aim: To evaluate clinical characteristics, maternal and neonatal outcomes among pregnant women with primary autoimmune thrombocytopenia (ITP).
Materials and methods: All pregnant women with ITP who had undergone antenatal follow-up and delivery at the Department of Obstetrics and Gynecology at a referral center, between 2011 and 2021, were retrospectively investigated. Patients were evaluated in three groups according to antenatal
treatment modality.
Results: 42 pregnant women with ITP were included in the study. A total of 29 (%69) pregnant womenhad been diagnosed with ITP before pregnancy and 13(%31) were diagnosed during pregnancy. 17 (%41) pregnant women did not receive any antenatal treatment, and 25 (%59) pregnant women receieved treatment. Postpartum haemorrhage (%50) was reported more frequently in the
steroids+IVIG group. A total of 42 pregnancies, 43 babies (one twin pregnancy, 41 singletons) were liveborn. Three neonates (%7) had thrombocytopenia and one of them had intracranial haemorrhage.
Conclusions: In pregnancies complicated with ITP, the platelet count is moderately or severely low, which can have adverse maternal and neonatal outcomes. Postpartum haemorrhage is a significant cause of maternal morbidity in cases with ITP. Therefore, pregnant women with ITP should be delivered in facilities that can adequately manage postpartum haemorrhage.
Gebelikte nadir bir akut karın nedeni: Spontan renal kalisiyel divertikül rüptürü
Authors: HEKİMSOY İlhan , BOZKAYA Halil , ÇAKMAK Özgür , GÜNEYLİ Serkan
Published: March 2023

Gebelikte üriner sistem komplikasyonları sık görülmekle birlikte renal toplayıcı sistem rüptürü oldukça

nadirdir. Bu çalışmada, ani başlangıçlı yan ağrısı nedeniyle tetkik edilen ve görüntüleme yöntemleri ile

spontan renal kalisiyel divertikül rüptürü tanısı alan gebe hasta sunulmaktadır. Kalisiyel divertiküller

genellikle insidental olarak saptanmakla birlikte nadiren gelişen rüptür sonucu akut karın etiyolojisinde

yer alırlar. Daha sık olarak izlenen akut karın nedenleri ile benzer klinik bulgular vererek tanısal

gecikmeye ve gebelikle ilişkili komplikasyonlara yol açabileceği için akut karın nedeniyle araştırılan

gebe olgularda nadir de olsa spontan renal kalisiyel divertikül rüptürü de akılda bulundurulmalıdır.
Deformed bladder activity mimicking pelvic crossed ectopic kidney on Technetium-99m labelled dimercaptosuccinic acid renal cortical scintigraphy
Authors: TAMER Fatih , YAZİCİ Bulent , ORAL Aylin , AKGÜN Aysegül
Published: March 2023

Technetium-99m dimercaptosuccinic acid (DMSA) scan was performed on a 32-year-old woman with

abdominal pain. A normal functioning slightly ptotic right kidney was seen on planar images. There

was no activity in the left renal region and a small fusiform activity was seen in the right pelvic area.

Pelvic computed tomography (CT) axial images revealed pre-vesical pelvic abscess pushing the

bladder posteriorly to the right side. On computed tomography images obtained after percutaneous

drainage it was concluded that the activity in the right pelvic area on Technetium-99m DMSA scan was

compatible with physiological activity in the bladder.
Forensic study on the effect of atypical surfaces and writing instruments on handwriting characteristics
Authors: Kaur Amanpreet
Published: March 2023

Handwriting examination is becoming a captivating field nowadays, as there are numerous cases where handwriting is not written on a usual surface – i.e., paper, with a conventional writing instrument – i.e., pen. However, while it is interesting to analyze these types of handwriting samples, most forensic document examiners find it difficult due to the effect atypical surface and writing instrument have on handwriting characteristics. Thus, a systematized study has been carried out on documents prepared on unconventional surfaces such as cardboard, cloth piece, and blackboard, with uncommon writing instruments such as lipstick, kajal, and chalk. Correspondingly, studies were carried out on writing samples provided by 40 individuals using the conventional pen/paper as well as unconventional cardboard/kajal, cardboard/pen, cloth/pen, cloth/lipstick, cloth/kajal, and board/chalk combinations. Various handwriting features were examined and compared among aforementioned combinations, and changes in handwriting characteristics were reported. Those could be due to the atypical writing instruments and surfaces which conjointly impact the overall identity of the handwriting and expert’s conclusions thereon.
Ablation of Kex2 activity enhances proIAPP proteotoxicity in yeast
Authors: Ferreira Sofia , F. Raimundo Ana , Farrim Inês , Menezes Regina
Published: March 2023

Pancreatic deposition of Islet Amyloid PolyPeptide (IAPP) is a histopathological hallmark of type 2 diabetes. Inadequate processing of immature IAPP by proprotein convertases (PCs) leads to the accumulation of unprocessed forms, which in turn favors increased aggregate formation in pancreatic β-cells. Kexin 2 (Kex2) of Saccharomyces cerevisiae is the prototype of eukaryotic PCs family, but to date no direct correlations between Kex2 activity and preproIAPP processing in yeast have been reported. In this study we aimed to address the possible role of Kex2 on IAPP maturation as a tool to investigate the contribution of impaired processing towards IAPP proteototoxicity. Genetically modified S. cerevisiae models lacking the KEX2 gene and carrying different chimeric fusions of human IAPP linked to GFP were used. The cytotoxic effects of Kex2 ablation were assessed by means of growth curve analysis and cell viability assays using flow cytometry. IAPP protein profile was evaluated by immunoblotting assays using an anti-IAPP antibody. Intracellular IAPP aggregates were monitored by confocal fluorescence microscopy. Data showed that kex2 mutants exhibit growth defects, potentiated by preproIAPP-GFP, proIAPP-GFP and mature IAPP-GFP expression with an increased cytotoxicity for proIAPP-GFP. Notwithstanding, Kex2 absence does not seem to affect IAPP protein pattern nor the frequency/distribution of intracellular IAPP aggregates in yeast. Our findings suggest that Kex2 is not essential for IAPP processing in yeast, at least under the conditions tested. Keywords: Amylin, Islet Amyloid Polypeptide (IAPP), Kexin 2, Prohormone processing, Saccharomyces cerevisiae
Economic hardship and intimate partner violence: An analysis of perpetrators in Germany
Authors: Schumann Nina , Bozoyan Christiane , Schmiedeberg Claudia
Published: March 2023

Objective: Based on the family stress model, we examine whether respondents are more likely to perpetrate physical IPV when experiencing economic hardship and pressure.
Background: Research has demonstrated an association of intimate partner violence (IPV) and economic factors. However, as the bulk of studies is limited to the female victim’s perspective, the picture remains incomplete; factors driving gender-specific effects and perpetration rates have thus far been overlooked.
Method: Using data from a large sample of individuals from the German Family Panel pairfam, which covers the period between 2009 and 2019, we employ pooled logistic regression models (n=6,661 individuals with 21,321 observations). Given the rich data source, we are able to control for a number of possible confounding effects. To correct for sample selection, we use calibrated design weights.
Results: Our analyses show that IPV perpetration is associated with poverty and economic pressure among women, but not men. When accounting for confounding factors such as the Big 5 personality traits and childhood experiences, these associations become insignificant. For men, unemployment is linked to IPV perpetration, but only when personality traits and childhood experiences are not accounted for.
Conclusion: Results imply that the association between adverse economic conditions and IPV perpetration is mainly due to unobserved heterogeneity. Thus, physical IPV perpetration is not primarily caused by the distress of financial strain, but rather by underlying factors such as personality traits and adverse childhood experiences, which are associated with both socioeconomic status, economic pressure, and aggressive behavior in intimate relationships.
Mobilitätspräferenzen und Preisflexibilität spezifischer Nutzergruppen im autonomen Fahren
Authors: Schmid Franziska , Teichert Matthias
Published: March 2023

Dieser Beitrag befasst sich mit Anforderungen und Wünschen von Endkunden in einer Mobilitätslandschaft der Zukunft, in der sich autonome Angebote bereits durchgesetzt haben und der Wechsel vom Piloten zum Passagier vollzogen ist. Wie wichtig sind Lernenden, DINKs, Familien und Silver Drivers ausgewählte Mobilitätsfaktoren (z. B. Pünktlichkeit und Komfort), wie spiegelt sich die Wichtigkeit in der Zahlungsbereitschaft wider und inwiefern unterscheiden sich die verschiedenen Nutzergruppen in ihren Mobilitätspräferenzen und Preisflexibilitäten? Diesen Fragen sind wir bei #FORTSCHRITT mit dieser Studie nachgegangen.
Ecologias antirracistas na Bahia: retratos da luta Pataxó contra o ecocídio e o genocídio
Authors: Braz Bomfim de Souza Arissana , Milanez Felipe
Published: March 2023

Este artigo discute a luta pela memória do povo Pataxó e a dimensão do racismo e do Colonialismo sobre a vida e o território-vida no sul da Bahia através do trabalho artístico de Arissana Pataxó. Em coautoria da artista com colega pesquisador em projeto de pesquisa sobre culturas de antirracismo, discutimos a dimensão do racismo e da colonialidade sobre a vida-território indígena. Através da pesquisa sobre lideranças de seu povo para a elaboração de retratos em desenhos e pinturas, o trabalho de Arissana Pataxó reconstrói uma história apagada de resistência à espoliação e ao genocídio após o massacre conhecido como o Fogo de 51.
Hijacking intercellular trafficking for the spread of protein aggregates in neurodegenerative diseases: a focus on tunneling nanotubes (TNTs)
Authors: Chakraborty Ranabir , Belian Sevan , Zurzolo Chiara
Published: March 2023

Over the years, the influence of secretory mechanisms on intercellular communication has been extensively studied. In the central nervous system (CNS), both trans-synaptic (neurotransmitter-based) and long-distance (extracellular vesicles-based) communications regulate activities and homeostasis. In less than a couple of decades, however, there has been a major paradigm shift in our understanding of intercellular communication. Increasing evidence suggests that besides secretory mechanisms (via extracellular vesicles), several cells are capable of establishing long-distance communication routes referred to as Tunneling Nanotubes (TNTs). TNTs are membranous bridges classically supported by F-Actin filaments, allowing for the exchange of different types of intracellular components between the connected cells, ranging from ions and organelles to pathogens and toxic protein aggregates. The roles of TNTs in pathological spreading of several neurodegenerative conditions such as Prion diseases, Alzheimer’s disease (AD), Parkinson’s disease (PD), and Huntington’s disease (HD) have been well established. However, the fragile nature of these structures and lack of specific biomarkers raised some skepticism regarding their existence. In this review, we will first place TNTs within the spectrum of intercellular communication mechanisms before discussing their known and hypothesized biological relevance in vitro and in vivo in physiological and neurodegenerative contexts. Finally, we discuss the challenges and promising prospects in the field of TNT studies.
The effects of Environmental, Social, and Governance (ESG) scores on firm values in ASEAN member countries
Authors: Prabawati Paulina Inggita , Rahmawati Isna Putri
Published: March 2023

This study examines the effect of Environmental, Social, and Governance (ESG) scores on firm value in ASEAN. This study uses data from 184 public companies listed on the stock exchanges of each country from 2010 to 2019. This study finds that ESG scores have a negative effect on firm value (Tobin's Q). This finding shows that the higher the ESG value, the lower the firm value (undervalued) in ASEAN. Furthermore, this study shows the influence of each pillar, namely the environmental, social, and governance. The environmental and social pillars negatively affect firm value, while the governance pillar has no effect. In ASEAN, a high ESG score is not considered an advantage for a company. This research has implications for companies to consider increasing information and compliance with environmental and social aspects of the company to increase their values. In addition, it also adds to the literature regarding the determinants of firm value on non-financial factors.
Auditor of personality and performance throughout the period of the pandemic
Authors: Budiandru Budiandru
Published: March 2023

Existing audit standards must guide auditors in carrying out their profession. Audit standards regulate auditors in compiling reports with good performance and according to the professional code of ethics. The goal of this study was to examine the impact of professional ethics, auditor independence, auditor experience, and auditor professionalism on auditor performance during a pandemic by taking samples from public accounting firms in Jakarta and Surabaya with 170 respondents. Using the Structural Equation Model (SEM), this study aims to solve the research questions. The findings of the study showed that auditor professionalism had an effect on auditor performance, while professional ethics, independence, and experience of auditors had no such effect. Public accounting firms must improve and maintain the professionalism of each auditor in order to avoid the manipulation of financial statements and produce maximum performance.
Autoimmune Inflammatory Reactions Triggered by the COVID-19 Genetic Vaccines in Terminally Differentiated Tissues
Authors: Polykretis Panagis , Donzelli Alberto , Lindsay Janci C. , Wiseman David , Kyriakopoulos Anthony M. , Mörz Michael , Bellavite Paolo , Fukushima Masanori , Seneff Stephanie , McCullough Peter A.
Published: March 2023

As a result of the spread of SARS-CoV-2, a global pandemic was declared. Indiscriminate COVID-19 vaccination has been extended to include age groups and naturally immune people with minimal danger of suffering serious complications due to COVID-19. Solid immuno-histopathological evidence demonstrates that the COVID-19 genetic vaccines can display an off-target distribution in tissues that are terminally differentiated, triggering autoimmune reactions. These include the heart and brain, which may incur in situ production of spike protein eliciting a strong autoimmunological inflammatory response. Due to the fact that every human cell which synthesizes non-self antigens becomes inevitably the target of the immune system, and since the human body is not a strictly compartmentalized system, accurate pharmacokinetic and pharmacodynamic studies are needed in order to determine precisely which tissues can be harmed. Therefore, our article aims to draw the attention of the scientific and regulatory communities on the critical need of bio-distribution studies for the genetic vaccines against COVID-19, as well as of rational harm-benefit assessments by age group.
Trichoderma asperellum Extract Isolated From Brazil Nuts (Bertholletia excelsa. BONPL): In Vivo and In Silico Studies on Melanogenesis in Zebrafish
Authors: Ferreira Adriana Maciel , Sena Iracirema da Silva , Curti Jhone , De Souza Agerdânio Andrade , Lima Paulo Cesar dos Santos , Rodrigues Alex Bruno Lobato , Ramos Ryan da Silva , Pinheiro Wandson Braamcamp de Souza , Ferreira Irlon Maciel , Carvalho José Carlos Tavares
Published: March 2023

Endophytic fungi are those that present part of their life cycle in healthy tissues of different plant hosts in symbiosis without causing harm. At the same time, fungus-plant symbiosis makes it possible for microorganisms to synthesize their own bioactive secondary metabolites while in stationary stage. Such microorganism-derived secondary metabolites contribute. Therefore, this work aimed to. To accomplish this, the endophytic fungus Trichoderma asperellum was isolated from Bertholletia excelsa (Brazil nut) almonds. The fungus was cultivated and extracted with ethyl acetate, obtaining AM07Ac. Then, using HPTLC (High-performance thin-layer chromatography) and Nuclear Magnetic Resonance (1H NMR), β-amyrin, kaempferol, and brucine were identified as major compounds. Further in vivo assays in Zebrafish demonstrated the activity of AM07Ac on melanogenesis by producing a concentration-response inhibitory effect, which, through an in silico study, proved to be related to the noted major compounds known to inhibit tyrosinase activity. The inhibition of tyrosinase prevents melanin accumulation in skin. Therefore, these results imply the importance of investigating microorganisms and their pharmacological activities, in particular the endophytic fungus Trichoderma asperellum as a generator of active metabolites for melanogenesis modulation.
Influence of Humidity and Heating Rate on the Continuous ZIF Coating during Hydrothermal Growth
Authors: Choi Eunji , Lee Choong Hoo , Kim Dae Woo
Published: March 2023

Zeolitic imidazolate frameworks (ZIFs) have potential for various gas and ion separations due to their well-defined pore structure and relatively easy fabrication process compared to other metal-organic frameworks. As a result, many reports have focused on preparing polycrystalline and continuous ZIF layers on porous supports. In this study, we investigated how humidity and chamber temperature influence the structure of a ZIF-8 layer prepared by the hydrothermal method. We controlled the chamber temperature (ranging from 50 °C to 70 °C) and relative humidity (ranging from 20 % to 100 %) using a thermos-hygrostat chamber. We found that as the chamber temperature increased, ZIF-8 preferentially grew into particles rather than forming a continuous polycrystalline layer. By measuring the temperature of the reacting solution based on chamber humidity, we discovered that the heating rate of the reacting solution varied with humidity, even at the same chamber temperature. At higher humidity, thermal energy transfer was accelerated as water vapor delivered more energy to the reacting solution. Therefore, a continuous ZIF-8 layer could be formed more easily at low humidity ranges (ranging from 20 % to 40 %), while micron ZIF-8 particles were synthesized at a high heating rate. Our findings suggest that controlling the heating rate of the reacting solution is critical to preparing a continuous ZIF-8 layer, particularly for future scale-up of ZIF-8 membranes.