bluuebunny/crossref_metadata_2025 huggingface dataset:
Gamification of nutrition: A preliminary study on the impact of gamification on nutrition knowledge, attitude, and behaviour of adolescents in Nigeria
Authors: Ezezika Obidimma , Oh Jessica , Edeagu Ngozi , Boyo Warami
Published: July 2018

Background:

In Nigeria and many parts of sub-Saharan Africa, the availability of foods that are high in salt, sugar, and saturated fat is steadily increasing. This has led to an increase in the consumption of such foods among Nigerians, particularly among adolescents.

Aim:

This pilot study was undertaken to understand whether, and how, gamification of nutrition can have an impact on addressing the problem of unhealthy eating among Nigerian adolescents.

Methods:

Gamification of nutrition through board games, clubs and vouchers was introduced in three secondary schools in Abuja, Nigeria over a span of three to four months. Semi-structured focus groups were conducted with grade 11 and 12 students in the three secondary schools. Participants were asked about their perceptions of the intervention and how it influenced their eating behaviour, attitudes and knowledge about nutrition.

Results:

A total of 31 students participated in four focus groups. Participants reported that the intervention shifted their perceptions and preferences, leading them to alter their behaviour by incorporating more nutritious foods (such as fruits and vegetables) into their diet and engaging in more physical activity. Five themes emerged from the analyses: improved eating behaviour; increased physical activity; improved overall well-being; increased nutrition knowledge; and influencing others.

Conclusions:

The results from the focus groups suggest that gamification of nutrition can lead to improvements in dietary behaviour among adolescents over the short-term. More studies are needed to evaluate the long-term effects of nutrition interventions that use gamification techniques.
Relationship between alkaline phosphatase and impaired coronary flow in patients with ST-segment elevated myocardial infarction
Authors: Edem Efe
Published: July 2018

Objective

Recent studies have shown that alkaline phosphatase (ALP) might play a negative role in clinical outcomes of patients with peripheral and coronary artery disease. This study aimed to investigate the relationship between serum ALP levels and coronary thrombolysis in myocardial infarction (TIMI) frame counts in patients with ST-segment elevated myocardial infarction undergoing primary percutaneous coronary intervention (PCI).

Methods

A total of 198 patients were enrolled in the current study. Serum ALP levels were measured in lithium-heparin plasma samples via a standardized, colorimetric enzyme assay. Coronary TIMI flow was evaluated by counting the number of cine frames that were required for contrast to reach a standardized distal coronary landmark in the culprit vessel.

Results

The Spearman correlation coefficient test showed strong positive relationships between coronary TIMI frame counts after primary PCI and serum ALP levels on admittance for the left anterior descending, circumflex, and right coronary arteries (r = 0.774, r = 0.831, and r = 0.730, respectively).

Conclusion

Elevated serum ALP levels appear to be a predictor of impaired coronary TIMI frame count in patients suffering from ST-segment elevated myocardial infarction.
Multivariable least squares support vector machine with time integral operator for the prediction of bearing performance degradation
Authors: Zhang Yao , Zhou Youguang , Tang Gang , Wang Huaqing
Published: July 2018

The prediction of performance degradation is significant for the health monitoring of rolling bearing, which helps to greatly reduce the loss caused by potential faults in the entire life cycle of rotating machinery. As a new method of machine learning based on statistical learning theory, least squares support vector machine is developed and has achieved good results. However, it lacks the description of the time-sum effect and delay characteristics, which cannot fully describe the performance degradation process. To overcome the problem, a new time shift least squares support vector machine with integral operator is proposed. What is more, multivariable prediction model is introduced to describe the process from multiple perspectives. In this model, different features are extracted to construct sample pairs through a moving window. Then these features are decomposed in time domain using a set of orthogonal basis functions to simplify computation. Furthermore, the model adaptability is also improved through an iterative updating strategy. Bearing fault experiments show that the proposed model outperforms the general method.
Radiostereometric analysis using clinical radiographic views: Validation with model-based radiostereometric analysis for the knee
Authors: Yuan Xunhua , Broberg Jordan S , Naudie Douglas DR , Holdsworth David W , Teeter Matthew G
Published: July 2018

Radiostereometric analysis is a sophisticated radiographic technique with high measurement accuracy. In order to improve the accessibility of radiostereometric analysis for clinical use, a modified radiostereometric analysis procedure has been previously proposed that enables clinical radiographic views to be used for radiostereometric analysis. It has been successfully validated for its application to the hip wear study with the conventional bead–based radiostereometric analysis environment using computed radiography. In this study, we describe the implementation and validation of this technique for the knee study with the model-based radiostereometric analysis environment using digital radiography. A knee-joint phantom with 6 degrees of freedom was examined, and the bias and repeatability/reproducibility of the modified radiostereometric analysis approach were investigated following the newly updated ASTM recommendations. The bias parameters (mean ± 95% confidence interval) ranged from 0.008 ± 0.003 mm to 0.027 ± 0.006 mm for translation and from 0.014° ± 0.007° to 0.040° ± 0.020° for rotation. The repeatability standard deviation ranged from 0.004 to 0.020 mm for translation and from 0.005° to 0.015° for rotation. The 95% repeatability limit ranged from 0.011 to 0.055 mm for translation and from 0.014° to 0.041° for rotation. The reproducibility standard deviation ranged from 0.004 to 0.023 mm for translation and from 0.006° to 0.040° for rotation. The 95% reproducibility limit ranged from 0.012 to 0.063 mm for translation and from 0.016° to 0.112° for rotation. The modified procedure allows routine clinical radiographs to be used for radiostereometric analysis, which provides the possibility of adding quantitative measurements to current patient registries.
‘Tout de noir vêtu’: Skin and surface in the rap of Abd al Malik
Authors: Shuman Emily Q.
Published: July 2018

This paper investigates the visual aesthetics of French rap with regard to questions of race and subjectivity through an analysis of both the lyrics and music videos of the rapper Abd al Malik. Abd al Malik addresses the central question of corporeal visibility in a ‘colour-blind’ French society. His performance depicts the skin as a surface, rooting his corporeal subjectivity in a tactile experience. Through the use of light, oversaturated colour and constantly shifting forms, Abd al Malik’s videos test the limits of vision to create a sensorial experience that incorporates, yet transcends, the visibility of epidermalised blackness. The consciousness of self and others is therefore not achieved by an unmasking or a shedding of blackness, but through the recognition of skin as a material surface that both challenges the presumption that an individual’s interiority is legible on the body’s exterior and invites the more complex, sensorial contact of universal, human relationality.
Therapeutic measures in a moving ambulance: Qualitative study of professional opinions regarding prehospital emergencies
Authors: Castejón-de la Encina María Elena , Sanjuán Quiles Ángela , del Moral Vicente-Mazariegos Ignacio , García-Aracil Noelia , Morales López Beatriz , Richart Martinez Miguel
Published: July 2018

Background:

current organization of the prehospital emergency teams, decreasing the prehospital times, given the possibility of working during the patient’s transport and, therefore, the consequences that may result from the same improving the prognostic.

Objectives:

To explore the opinion of professional healthcare experts regarding prehospital emergencies arising when forced to assist a critical patient in a moving vehicle, based on a high-fidelity clinical simulation, as well as the factors influencing them.

Methods:

An exploratory study of content analysis with qualitative methodology, via semi-structured questionnaires that are self-completed anonymously, before and after the clinical simulation intervention in which participants intubate a mannequin in a moving ambulance. The sample consisted of 36 experts in prehospital emergencies from the province of Alicante (Spain). Codification and assessment of the data obtained was carried out via triangulation, respecting the language and literal expressions of the participants.

Results:

Thirty-two pre- and post-intervention questionnaires were completed. Four different units of meaning or categories emerged which were organized based on two thematic structures, from the perspective of professional and patient needs. Twenty-three participants had never previously intubated in a moving vehicle.

Discussion:

Working in a moving vehicle may be yet another aspect to consider in the specialized teaching–learning process of prehospital emergency medicine.

Conclusion:

Based on the need to decrease prehospital assistance times, a new paradigm has been opened in prehospital emergencies with the possibility of being able to safely assist our patients during their transport on a moving ambulance or helicopter. It will be necessary further research in the future.
Comparison of Interactive Education Versus Fluorescent Concretization on Hand Hygiene Compliance Among Primary School Students: A Randomized Controlled Trial
Authors: Öncü Emine , Vayısoğlu Sümbüle Köksoy , Lafci Diğdem , Yurtsever Dilek , Bulut Ebru Ravlı , Peker Esra
Published: July 2018

Hand hygiene for children is crucial to keep them healthy. The purpose of the study was to evaluate the effects of two educational initiatives on “handwashing effectiveness (HWE).” A randomized controlled trial was carried out during April/June 2016, and 96 primary school students were randomly assigned to Group I receiving education with fluorescent gel; Group II receiving interactive education or control group continuing its normal education. Evaluation was made by scoring the fluorescent areas on the hands with photographs. There were significant differences in handwashing scores between preprogram and postprogram for all areas in only Group II ( p < .05). HWE increased from 17.9% to 18.4% in Group I, from 15.4% to 37.7% in Group II, and from 35.5% to 35.8% in control group. Only concretization with fluorescent gel is not a sufficiently strong motivator for increasing HWE. New techniques should be integrated into the training programs for children.
Nattokinase: A Promising Alternative in Prevention and Treatment of Cardiovascular Diseases
Authors: Chen Hongjie , McGowan Eileen M , Ren Nina , Lal Sara , Nassif Najah , Shad-Kaneez Fatima , Qu Xianqin , Lin Yiguang
Published: July 2018

Cardiovascular disease (CVD) is the leading cause of death in the world and our approach to the control and management of CVD mortality is limited. Nattokinase (NK), the most active ingredient of natto, possesses a variety of favourable cardiovascular effects and the consumption of Natto has been linked to a reduction in CVD mortality. Recent research has demonstrated that NK has potent fibrinolytic activity, antihypertensive, anti-atherosclerotic, and lipid-lowering, antiplatelet, and neuroprotective effects. This review covers the major pharmacologic effects of NK with a focus on its clinical relevance to CVD. It outlines the advantages of NK and the outstanding issues pertaining to NK pharmacokinetics. Available evidence suggests that NK is a unique natural compound that possesses several key cardiovascular beneficial effects for patients with CVD and is therefore an ideal drug candidate for the prevention and treatment of CVD. Nattokinase is a promising alternative in the management of CVD.
Investigating Risk Adjustment Methods for Health Care Provider Profiling When Observations are Scarce or Events Rare
Authors: Brakenhoff Timo B , Moons Karel GM , Kluin Jolanda , Groenwold Rolf HH
Published: July 2018

Background:

When profiling health care providers, adjustment for case-mix is essential. However, conventional risk adjustment methods may perform poorly, especially when provider volumes are small or events rare. Propensity score (PS) methods, commonly used in observational studies of binary treatments, have been shown to perform well when the amount of observations and/or events are low and can be extended to a multiple provider setting. The objective of this study was to evaluate the performance of different risk adjustment methods when profiling multiple health care providers that perform highly protocolized procedures, such as coronary artery bypass grafting.

Methods:

In a simulation study, provider effects estimated using PS adjustment, PS weighting, PS matching, and multivariable logistic regression were compared in terms of bias, coverage and mean squared error (MSE) when varying the event rate, sample size, provider volumes, and number of providers. An empirical example from the field of cardiac surgery was used to demonstrate the different methods.

Results:

Overall, PS adjustment, PS weighting, and logistic regression resulted in provider effects with low amounts of bias and good coverage. The PS matching and PS weighting with trimming led to biased effects and high MSE across several scenarios. Moreover, PS matching is not practical to implement when the number of providers surpasses three.

Conclusions:

None of the PS methods clearly outperformed logistic regression, except when sample sizes were relatively small. Propensity score matching performed worse than the other PS methods considered.
Distribution Matters: Feminist Bookstores as Cultural Interaction Spaces
Authors: Liddle Kathy
Published: July 2018

To investigate the historical case of North American feminist bookstores, I use archival materials, interviews, and surveys to consider how cultural distribution sites affect the acquisition and interpretation of cultural objects. The findings point to the importance and variety of distributor conditions, including physical space, atmosphere, bookseller characteristics, stock, and audience members. I develop the concept of the cultural interaction space, defined as a location where a distributor, its cultural objects, and its audience converge. These spaces provide opportunities for interaction, observation, and experimentation with both tangible and intangible cultural materials, as well as for identity formation and the development of group solidarity. Future research should consider how variations in cultural distributors and in cultural interaction spaces affect audience reception, interpretation, and use of cultural objects.
Transition from service to civvy street: the needs of armed forces veterans and their families in the UK
Authors: Fulton E , Wild D , Hancock J , Fernandez E , Linnane J
Published: July 2018

Aims:

Although many veterans make the transition from military to civilian life without difficulty, a small proportion struggle due to an impact on mental and physical wellbeing. Stigma and a reluctance to seek help further exacerbate this problem. The Armed Forces Covenant outlines the importance of ensuring that public services are aware of the specific needs of veterans; however, evidence suggests that knowledge among professional staff may be limited.

Methods:

This exploratory study included three phases. Phase 1 (questionnaires) explored the needs of veterans and their families in Warwickshire (UK) regarding information about their health and wellbeing and the barriers and facilitators to accessing local public health services. Also in Phase 1, health and public services staff knowledge of veterans’ needs and the Covenant is explored. In Phase 2, both samples attended a related focus group for a more in-depth exploration of the issues identified in Phase 1; in order to inform a Phase 3 workshop to co-develop an intervention.

Results:

Veterans, their families and friends, wanted more information about what services do, how and when to access them and what to expect. Confusion over when to seek help for mental health ‘symptoms’ was highlighted. More support for families was identified, alongside a need for health and social care staff to have a better understanding of the unique experiences and needs of veterans. Only 35% of staff reported a good understanding of the Armed Forces Covenant and their responsibilities to uphold it.

Conclusions:

Public health teams within UK local authorities are well placed to ensure veterans have more knowledge about and access to public services. Interventions to address stigma and veterans’ reluctance to seek help were needed. To this end, interventions for local veterans, their loved ones and staff in public services, designed in co-creation with these groups, is discussed.
“Be Ready for It”
Authors: DeCino Daniel A. , Waalkes Philip L. , Matos Cristina
Published: July 2018

School counselors’ experiences with subpoenas and testifying in court remain relatively unknown. In this narrative study, we examined 14 school counselors’ experiences with the legal system. The data analysis process uncovered three themes in participants’ experiences: (a) professional intentions, (b) interpersonal connections, and (c) experiences with legal proceedings. We discuss implications for school counselors and counselor educators regarding legal proceedings and directions for future research.
Fertility outcome after treatment of retained products of conception: a systematic review
Authors: Hamerlynck Tjalina W. O. , Meyers Dora , Van der Veken Hannelore , Bosteels Jan , Weyers Steven
Published: July 2018

Background

Treatment of retained products of conception (RPOC) can be expectant, medical or operative. Surgical removal of RPOC may lead to intrauterine adhesions (IUA) and Asherman’s syndrome.

Objective

To evaluate how treatment options for RPOC affect future fertility by means of a systematic review.

Search strategy

MEDLINE, EMBASE, The Cochrane Library, and clinical trial registers were searched, and reference lists were scanned.

Selection criteria

Randomised controlled trials (RCT) comparing different treatment options for RPOC (conservative, medical or surgical treatment, including curettage and/or hysteroscopic techniques, with or without application of anti-adhesion therapy), in women of reproductive age, were eligible for inclusion.

Data collection and analysis

Reviewers independently performed data extraction and quality of evidence assessment. For dichotomous variables, results were presented as risk ratio (RR) with 95% CI.

Main results

Two studies were included. Nonsignificant differences were observed between the use of an anti-adhesion barrier gel versus no treatment after operative hysteroscopy in IUAs (RR 0.32, 95% CI 0.04 to 2.80, P value = 0.30) and clinical pregnancy (RR 2.22, 95% CI 0.67 to 7.42, P value = 0.19), and between hysteroscopic morcellation versus loop resection in IUAs (RR 0.86, 95% CI 0.06 to 13.12, P value = 0.91).

Conclusion

There is insufficient evidence on how different treatment options for RPOC affect future reproductive outcomes. Results from ongoing RCTs are needed to guide clinicians towards choosing the best treatment.
Proton relative biological effectiveness (RBE): a multiscale problem
Authors: Underwood Tracy SA , McMahon Stephen J
Published: July 2018

Proton radiotherapy is undergoing rapid expansion both within the UK and internationally, but significant challenges still need to be overcome if maximum benefit is to be realised from this technique. One major limitation is the persistent uncertainty in proton relative biological effectiveness (RBE). While RBE values are needed to link proton radiotherapy to our existing experience with photon radiotherapy, RBE remains poorly understood and is typically incorporated as a constant dose scaling factor of 1.1 in clinical plans. This is in contrast to extensive experimental evidence indicating that RBE is a function of dose, tissue type, and proton linear energy transfer, among other parameters. In this article, we discuss the challenges associated with obtaining clinically relevant values for proton RBE through commonly-used assays, and highlight the wide range of other experimental end points which can inform our understanding of RBE. We propose that accurate and robust optimization of proton radiotherapy ultimately requires a multiscale understanding of RBE, integrating subcellular, cellular, and patient-level processes.
Differentiating vacuum-assisted breast biopsy from core needle biopsy: Is it necessary?
Authors: Nakano Satoko , Imawari Yoshimi , Mibu Akemi , Otsuka Masahiko , Oinuma Toshinori
Published: July 2018

Needle biopsy has replaced excisional biopsy as a definitive diagnostic technique for breast tumours, although excisional biopsy is still used for complete tumour removal for therapeutic and/or diagnostic purposes. Many vacuum-assisted breast biopsy (VAB) systems have been made available by several manufacturers since the release of the Mammotome (MMT) by Johnson & Johnson in 1995. Several recent discussions have been conducted to identify whether core needle biopsy (CNB) or VAB, is more appropriate. However, currently available VAB systems differ from the conventional system (i.e. articulate arm type 11-gauge(G) MMT), and the characteristics of both CNB and VAB have been improved. In CNB, a 14-G needle is frequently used to obtain a larger sample. By contrast, VAB is considered easier to perform because it uses a thinner needle and a lighter, non-tethered system. When differentiating CNB from VAB, the type of VAB should also be defined. In this review, we discuss the characteristics of ultrasonography-guided VAB and CNB with a focus on practical issues such as the number of samples and volume of tissue obtained during ultrasonography-guided needle biopsy.
Facilitadores para a prática de atividade física no lazer em adolescentes
Authors: Camargo Edina , De Paiva Hermes , Pacheco Henrique , De Campos Wagner
Published: July 2018

O objetivo do estudo foi identificar os facilitadores para a prática de atividade física no lazer em adolescentes do ensino médio de São José dos Pinhais (PR). Foi realizada a técnica de grupos focais, da pesquisa qualitativa, seguindo um roteiro semiestruturado, com adolescentes de 14 a 17 anos de idade (50% do sexo feminino, média de idade de 15,5 ±1,5) de escolas públicas e privadas. Ao total foram realizados 12 grupos focais, sendo metade para cada sexo e tendo adolescentes ativos e inativos fisicamente. Para a análise dos dados foi utilizado a análise de conteúdo e a estatística descritiva para contabilizar os relatos. Os resultados foram analisados separadamente por tipo de escola e sexo. Os facilitadores mais relatados foram: apoio social dos amigos (12,2%), apoio social dos pais (11,7%), ter habilidades (11,1%), educação física trabalhar as habilidades motoras e físicas (10,3%) e praticar atividade física no contraturno das aulas (7,6%). Para maximizar os níveis de atividade física no lazer em adolescentes, deve-se levar em consideração os facilitadores encontrados nesse estudo, que dizem respeito ao apoio social e a prática efetivamente, seja ela para o aprendizado de habilidades motoras e físicas, ou para o aprimoramento, tanto nas aulas de educação física escolar quanto nas atividades físicas no contraturno.
Adesão e aderência a um programa de exercício físico em pessoas vivendo com HIV/AIDS
Authors: Oliveira Junior João , Guariglia Débora , Loch Mathias
Published: July 2018

O objetivo do estudo foi identificar barreiras percebidas à prática de atividade física antes e após participarem de um programa de exercícios físicos (EF), bem como aspectos ligados à adesão e a aderência à este programa, em pessoas vivendo com HIV/aids, especificamente: motivos referidos para faltas as sessões, número de desistências ao longo do programa, continuidade de prática após seis meses ao término do programa e motivos para eventuais não continuidades. Dezenove sujeitos participaram de 14 semanas de um programa de EF. Foram coletadas informações sobre barreiras percebidas para a prática de atividade física, os motivos de faltas ou desistência e a continuidade após seis meses ao término do programa. Para análise dos dados utilizou-se estatística descritiva, o teste de McNemar para verificar as diferenças nas frequências de cada barreira, e de Wilcoxon para comparar o número médio de barreiras no momento pré e pós programa. A média de assiduidade às sessões foi de 58,5% e os principais motivos relatados para as faltas foram “problemas de saúde” e “compromissos pessoais”. Cerca de 40% das pessoas que iniciaram o programa não chegaram até o final do mesmo. A maior parte das desistências aconteceu entre a 11a e a 20a sessão. Não houve diferenças significativas nas barreiras referidas pré e pós programa, nem no número médio de barreiras. Somente 21% dos sujeitos referiram estar praticando EF após seis meses. Programas de EF devem considerar estes achados e buscar elaborar ações mais sustentáveis e de maior impacto a longo prazo na saúde dos sujeitos.
PERSONAGENS FEMININAS DO LIVRO PARADIDÁTICO “TOSCO”: EDUCAÇÃO SOBRE GÊNERO E IDENTIDADE
Authors: Cunha Diego Fernando , Silva Maria De Lourdes da
Published: July 2018

O presente trabalho é resultado da pesquisa desenvolvida no âmbito do projeto “Materiais Didáticos e Paradidáticos sobre Medicamentos, Álcool e Outras Drogas para o Ensino Básico: abordagens, linhas de ação e finalidades”, que analisa as publicações dos últimos 20 anos no Brasil. As fontes analisadas são o livro paradidático Tosco (2009), de Gilberto Mattje, escrito para alunos do terceiro e quarto ciclos do fundamental, que trata dos conflitos adolescentes e riscos implicados nessa fase da vida; e o livro Compreendendo Tosco (2011) escrito, pelo mesmo autor, como um guia de leitura autorizada do primeiro, especialmente voltado aos professores, com indicações de atividades para serem trabalhadas com os alunos. O objetivo foi analisar o processo de construção das personagens femininas do livro Tosco, considerando, como aspecto mais geral da análise, que as circunstâncias criadas para a leitura participam da construção dos seus significados (CHARTIER, 2002); como aspecto mais específico, que as representações de gênero e sexualidade são construídas por meio de múltiplas aprendizagens e práticas, por meios nem sempre explícitos (LOPES, G., 2008) e que tais aprendizagens e práticas reforçam identidades sociais e políticas forjadas por discursos ancorados na tradicional forma de acumulação de conhecimento pelo pensamento ocidental (MIGNOLO, 2008). Nossa análise buscou compreender os sentidos das políticas públicas que deram/dão sustentação à adoção destes livros pelas escolas públicas brasileiras. Concluímos que a luta das mulheres pelo direito de falar de si e por si não encontra amparo nestes livros.
RESILIENT EDUCATIONAL LEADERS IN TURBULENT TIMES: APPLYING THE LEADER RESILIENCE PROFILE ® TO ASSESS RESILIENCY IN RELATIONSHIP TO GENDER AND AGE
Authors: Reed Diane
Published: July 2018

Mulheres líderes em todo o mundo enfrentam um desafio comum: tempos extremamente turbulentos, que desafiam até mesmo as/os líderes mais habilidosas(os). O artigo começa com uma breve visão geral do significado da resiliência da(o) líder e descreve o ciclo de resiliência que todas(os) as/os líderes experimentam quando ocorrem as adversidades. São cinco as fases do ciclo de resiliência discutidas: condições normais, fase de deterioração, fase de adaptação, fase de recuperação e fase de crescimento. Em seguida, o artigo traça o desenvolvimento dos dados revisados do Leader Resilience Profile® (LRP) que comparam e contrastam a resiliência da(o) líder por gênero e idade. Os resultados mostram claramente que a resiliência aumenta de forma confiável com a idade. Os participantes na faixa etária acima de 60 anos, em comparação com todas as outras faixas etárias combinadas, tiveram escores de resiliência significativamente mais altos. Na faixa etária de 20 a 29 anos, os homens apresentavam uma resistência mais alta do que as mulheres. Não houve diferenças de gênero confiáveis na resiliência nas outras categorias de idade. Os resultados são baseados em uma amostra relativamente pequena. Pesquisas adicionais devem ser conduzidas em amostras maiores em cada faixa etária. O artigo conclui abordando duas questões: Como a LRP pode ser usada em todos os países para avaliar a resiliência das mulheres líderes e como a LRP pode ser aplicada para desenvolver oportunidades de crescimento profissional para fortalecer a resiliência das mulheres líderes.
Preliminary results of bowl trapping bees (Hymenoptera, Apoidea) in a southern Brazil forest fragment
Authors: Gonçalves Rodrigo B. , Oliveira Priscila S.
Published: July 2018

In recent years bowl traps have gained attention as a useful method for sampling bees and are now commonly used across the world for this purpose. However, specific questions about the method itself have not yet been tested on different regions of the globe. We present the preliminary results of bowl trapping in a Semidecidual Seasonal forest fragment in southern Brazil, including the test of two different color bowls, two different habitats, and the interaction of these variables in bee species number and composition. We used blue and yellow bowls in the border and in the core trails of the forest fragment. In five sampling days between October to December bowl traps captured 745 specimens of 37 morphospecies, with Halictinae bees being the richest and most abundant group. Non parametrical statistical analyses suggested that different colors of bowl traps influenced bee richness and composition and thus, they should be used together for a more complete sampling. Different trails influenced only the composition, while the interaction with different colors did not have a significant effect. These results, as well as the higher taxonomic composition of the inventoried bees, are similar to other studies reported in the literature.
Educação Ambiental crítica em espaço não formal: mapeamento ambiental da região de São Domingos no município de Sumaré/SP
Authors: Pereira Áurea Cristina Bastos da Costa , Tomazello Maria Guiomar Carneiro
Published: July 2018

Este trabalho é resultante de uma pesquisa-ação participativa realizada em uma região de Sumaré/SP que congrega vários bairros de baixa renda, com os moradores vivendo em situação de risco. Por meio da construção de um mapeamento ambiental, discutiram-se questões do e no cotidiano com os adolescentes, moradores dessas localidades, atendidos por uma ONG local. O objetivo foi problematizar a realidade de forma a instrumentalizá-los para o enfrentamento dos problemas socioambientais, identificados no desenrolar da pesquisa, para que estes deixem de ser naturalizados por eles e passem a ser compreendidos como o produto de determinadas formas de organização social e considerados em seu contexto sócio-histórico.
As unidades de Conservação na perspectiva da Educação Ambiental
Authors: Cruz Camila Aparecida Da , Sola Fernanda
Published: July 2018

A educação ambiental é referenciada pelo SNUC como uma ferramenta importante para a criação, manutenção e valorização desses locais. Já a PNEA prevê que essa deverá ser uma prática recorrente e acessível a toda população. O entendimento de como ocorre a intersecção desses dois assuntos é o produto deste artigo. Para embasar as discussões, além das referências legais e científicas, utilizaram-se, também, as Diretrizes para a Estratégia Nacional de Comunicação e Educação Ambiental em Unidades de Conservação, que pretende nortear as ações de educação ambiental nesses espaços. Espera-se, assim, com a tessitura desse estudo teórico projetar os aspectos que favoreçam as ações de educação ambiental em unidades de conservação, além de incitar uma reflexão sobre a real função dessas áreas.
A presença da temática socioambiental nos TCCs do curso de Ciências Biológicas da UNOCHAPECÓ
Authors: Manila Colpani Ingridy , Dickmann Ivo , Da Rosa Luciane , Henrique Larissa
Published: July 2018

Este artigo analisou se dentro do curso de Ciências Biológicas da Universidade Comunitária da Região de Chapecó - Unochapecó, estão sendo abordados, nos trabalhos de conclusão de curso, temas referentes à temática socioambiental. Com isso, verificou-se em quais correntes de Educação Ambiental estes trabalhos se enquadram. Como metodologia utilizou-se a análise de conteúdo, tendo como base teórica o legado de Freire referente à relação ser humano e mundo, o seu papel em sociedade e sua capacidade de transformação da realidade-ambiente. Conclui-se que há uma inegável importância da formação dos educadores para o ensinamento do conhecimento em Educação Ambiental e que o curso de Ciências Biológicas tem fomentado uma diversidade de estudos socioambientais distribuídos em diversas correntes de Educação Ambiental.
Raggio, S. (2017). Memorias de la Noche de los Lápices. Tensiones, variaciones y conflictos en los modos de narrar el pasado reciente.
Authors: Pighin Daniela
Published: July 2018

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Kisspeptin increases intracellular calcium concentration by protein kinase C-mediated signaling in the primary cultured neurons from rat hippocampus
Authors: Serhatlioglu Ihsan , Yuksel Hande , Kacar Emine , Ozcan Sibel , Canpolat Sinan , Ozcan Mete , Ayar Ahmet , Kelestimur Haluk
Published: July 2018

In addition to the fact that kisspeptin and its receptor GPR54 are well known to be abundantly expressed in the hypothalamus with suggestive roles in the initiation of puberty and similar reproductive system properties, there is also proof showing that kisspeptin might have influences on hippocampal functions. In our previous study, it was shown that kisspeptin increased free intracellular Ca2+ values ([Ca2+]i) through protein kinase C (PKC) activation in GT1-7 cells. For this reason, we examined the influences of kisspeptin on [Ca2+]i in hippocampal neurons to determine if kisspeptin shows its effects on hippocampus through the same mechanism. Hippocampal neurons were excised from the brains of fetuses on 17th embryonic day from maternal rats. The influences of kisspeptin on [Ca2+]i in hippocampal neurons were examined through in vitro calcium imaging system. The responses of [Ca2+]i to kisspeptin were quantified by the changes in 340nm/380nm ratio.  Kisspeptin-10 caused [Ca2+]i transients in hippocampal neurons. The change in [Ca2+]i by 100 nM kisspeptin was prevented by pre-treating the cells in PKC inhibitor chelerythrine chloride. According to the results, kisspeptin activates intracellular calcium signaling in hippocampal neurons via the pathway that depends on PKC. The results of this study suggest that kisspeptin may have a role in hippocampal neuron functions.
Pomegranate peel extract inhibits expression of Î²-catenin, epithelial mesenchymal transition, and metastasis in triple negative breast cancer cells
Authors: Bagheri Mehdi , Fazli Mozhgan , Saeednia Sara , Kor Aylar , Ahmadiankia Naghmeh
Published: July 2018

The standard treatment for triple-negative breast cancer (TNBC) is chemotherapy, which is highly toxic to patients; thereby, there is a need to identify safer and more effective therapeutic approaches. Medicinal plants constitute a common alternative for cancer treatment. Pomegranate is a well-known fruit in this context, but its antimetastatic property has not been extensively studied. As breast cancer-related deaths from TNBC are mainly due to metastasis, the present study was designed to investigate the antimigratory effect of pomegranate peel extract (PPE) on TNBC cells. For this purpose, the MDA-MB-231 cells were treated with different concentrations of PPE for 24, 48 and 72 hr. The effects of PPE on cell migration and invasion were determined by wound healing and transwell assays. To address the possible molecular mechanisms underlying the antimetastatic effect of PPE, real-time quantitative PCR analysis of selected epithelial mesenchymal transition (EMT) markers were performed. Moreover, the expression of Î²-catenin as a critical factor in promoting cancer metastasis was examined. PPE markedly inhibited the migration and invasion of cells at concentrations of 25, 50, 100, 250, 500, and 1000µg/ml. At relatively high concentrations (500, 1000µg/ml), PPE induced apoptosis. Moreover, PPE decreased the gene expression of vimentin, ZEB1, and Î²-catenin and also increased the expression of E-cadherin in TNBC cells. The protein level of Î²-catenin, as measured using western analysis, revealed a time-dependent decrease at the concentration of 1000µg/ml PPE. Downregulation of EMT markers and Î²-catenin showed accordance with the inhibition of migration and invasion. The present data show that PPE could be a promising drug candidate to reduce metastasis in TNBC cells.
Involvement of transforming growth factor beta 1 in the transcriptional regulation of nicotinamide N-methyltransferase in clear cell renal cell carcinoma
Authors: Campagna Roberto , Cecati Monia , Pozzi Valentina , Fumarola Stefania , Pompei Veronica , Milanese Giulio , Galosi Andrea Benedetto , Sartini Davide , Emanuelli Monica
Published: July 2018

Renal cell carcinoma (RCC) is the most common tumor of the kidney and its major histologic subtype is clear cell RCC (ccRCC). About 30% of diagnosed ccRCCs already have metastasis. Traditionally, localized ccRCC is treated with nephrectomy but the relapse rate is 30%. Thus, the discovery of effective biomarkers for early detection, as well as the identification of new targets for molecular-based therapy of ccRCC are urgently required. In this study, we focused on molecules that could modulate the trascription of the enzyme nicotinamide N-methyltransferase (NNMT) that is known to be up-regulated in ccRCC. Signal transducer and activator of transcription 3 (STAT3), interleukin 6 (IL-6), hepatocyte nuclear factor 1 beta (HNF-1Î²) and transforming growth factor beta 1 (TGF-Î²1) expression levels were determined in tumor and non tumor samples obtained from 30 patients with ccRCC, using Real-Time PCR. Results obtained showed that TGF-Î²1 is significantly (p<0.05) overexpressed in tumor compared with normal tissue samples of ccRCC patients. Conversely, we did not find any statistically significant difference concerning STAT3, IL-6, HNF-1Î² gene expression levels. TGF-Î²1 up-regulation could be responsible for the high levels of NNMT observed in ccRCC. Targeting TGF-Î²1 could improve the outcome of ccRCC patients due to its role in epithelial-mesenchymal transition (EMT), that is known to be associated with a worse overall survival (OS) in this neoplasm.
Adherence and long-term growth outcomes: results from the easypod™ connect observational study (ECOS) in paediatric patients with growth disorders
Authors: Koledova Ekaterina , Stoyanov George , Ovbude Leroy , Davies Peter S W
Published: July 2018

Objective

The easypod connect observational study (ECOS) assessed treatment adherence among paediatric patients receiving growth hormone (GH) via the easypod electronic injection device.

Design

ECOS was an open-label, observational, longitudinal study conducted in 24 countries between 2010 and 2016, enrolling children treated with GH.

Methods

The primary endpoint was the rate of treatment adherence during 5 years of follow-up. Impact of adherence on growth outcomes was assessed using Spearman’s product–moment correlations.

Results and conclusions

Overall, 1190 patients had easypod data available for ≥3 months; most patients had GH deficiency (75%); 606 of these patients were GH naïve at baseline. Over the first year of monitoring, the median rate of adherence was 93.7% among patients overall and >93.0% in GH-naïve patients, irrespective of the treatment indication. Clinically meaningful improvements in growth rates were observed after 1 year of treatment across all GH indications. Adherence decreased with increasing treatment duration, but the overall median adherence rate remained high after 3 years of follow-up: 87.2% (n = 409), 75.5% after 4 years (n = 143) and 70.2% after 5 years (n = 43). Statistically significant correlations between adherence and 1-year change in height standard deviation score (P < 0.001 for patients overall) and height velocity (P < 0.001) were observed.

Conclusions

ECOS produced accurate, real-time adherence data in a large population of GH-treated children over 5 years of follow-up. Using the easypod connect system, physicians can potentially identify patients with inadequate adherence and poor response to treatment, enabling them to take appropriate action to help them maximise the benefits of GH treatment.
Clinical Implications of the Revised AAP Pediatric Hypertension Guidelines
Authors: Khoury Michael , Khoury Philip R. , Dolan Lawrence M. , Kimball Thomas R. , Urbina Elaine M.
Published: July 2018

BACKGROUND AND OBJECTIVES:

New pediatric hypertension definitions were recently published in a clinical practice guideline (CPG). We evaluated the impact of the CPG, compared with the previous guideline ("Fourth Report on the Diagnosis, Evaluation, and Treatment of High Blood Pressure in Children and Adolescents"), on the prevalence of hypertension and associations with target organ damage (TOD) in high-risk youth.

METHODS:

Participants (10–18 years old) undergoing an evaluation of the cardiovascular effects of obesity and type 2 diabetes mellitus in youth were studied. Blood pressure was categorized according to the 2 guidelines as normal, elevated, and hypertension (stages 1 and 2). Measures of TOD (carotid artery intima-media thickness, pulse wave velocity, left ventricular mass, and diastolic function) were obtained. Associations between blood pressure categories and TOD and the sensitivity of hypertension classification in identifying TOD were evaluated.

RESULTS:

Data were available for 364 participants (65% female sex; 15.1 ± 2.1 years of age). Hypertension was identified in 8% and 13% as defined in the Fourth Report and CPG, respectively (P = .007). The 2 guidelines revealed similar associations with TOD; however, the CPG demonstrated improved sensitivity of TOD detection in hypertensive participants. For example, the proportion of participants with an abnormal left ventricular mass categorized as hypertensive increased from 20% to 31% as defined in the Fourth Report and CPG, respectively (P < .001).

CONCLUSIONS:

Incorporation of the CPG increased the prevalence of pediatric hypertension in a population of high-risk youth and improved the sensitivity of TOD identification in hypertensive participants.
Evolución del concepto producto y servicio en la biblioteca: organización orientada al servicio e intensiva en conocimiento
Authors: Morales López Valentino
Published: July 2018

El presente artículo tiene por objeto el análisis de lo que significa la biblioteca como organización orientada al servicio e intensiva en conocimiento. El supuesto del que se parte es que se ha aseverado que una característica de la biblioteca es ser una institución pionera en la prestación de servicio, y en el contexto de la sociedad de la información y del conocimiento adquiere un papel trascendental. Sin embargo, la respuesta que esta institución presente a la sociedad no solo debe ser externa, también hay que plantear nuevos marcos conceptuales que permitan entender de qué forma la organización interna de la biblioteca se debe reconfigurar, entendida como una organización intensiva en conocimiento. Así que la principal conclusión es que la biblioteca es de tipo rutinaria con alto grado de especialización e integra elementos simbólicos, y para su adecuado funcionamiento necesita tener un alto grado de comunicación entre sus integrantes.
La disputa del ser: voces y saberes en las mujeres, las pugnas coloniales, el Estado y el progreso en Calypso, de Tatiana Lobo
Authors: Barboza Núñez Esteban
Published: July 2018

El artículo explica, haciendo uso de herramientas teóricas decoloniales, postcoloniales y de feminismos decoloniales, las tensiones y disputas en la novela Calypso, de Tatiana Lobo, en torno a la integración del sur de la provincia de Limón, escenario principal de texto, al proyecto de Estado nacional costarricense. Se analiza el contrapunteo de saberes y voces tanto locales, como exteriores, es decir, de la cultura hegemónica costarricense, a lo largo de las tres generaciones narradas en la novela y durante las cuales ocurre dicha integración. Asimismo, se analizan aspectos relacionados con las unidades de producción, la religión, la educación, las mujeres del texto, las formas de convivencias y los resultados de dichas tensiones.
LA PUBLICACIÓN CONTINUA Y LA PUBLICACIÓN PRELIMINAR: MODALIDADES DE PUBLICACIÓN ELECTRÓNICA EN PENSAR EN MOVIMIENTO
Authors: Quirós Segura Fabiola
Published: July 2018

Se presentan las características de estas dos modalidades de publicación electrónica, ampliamente utilizadas a nivel mundial.
COSTA RICA SIN FRONTERAS #17
Authors: Aragón-Vargas Luis Fernando
Published: July 2018

En esta sección se publican los resúmenes en español de artículos que han sido publicados por investigadoras/es de universidades costarricenses en otras revistas en el mundo, con su debida referencia al trabajo original, y con una breve explicación de dónde se realizó la investigación. Los artículos originales han sido publicados en otros idiomas; las revistas tienen consejo editorial y manejan un proceso de revisión por pares. Los resúmenes corresponden a estudios relacionados con las ciencias del ejercicio y la salud, que se conforman a los criterios generales de la revista, esto es, se trata de “... estudios experimentales o que hagan recomendaciones concretas para solucionar problemas o preguntas relevantes (...) trabajos originales o de meta-análisis.” Solicitamos a quienes hayan publicado este tipo de trabajos en otros idiomas que no los hagan saber, para incluir sus resúmenes en futuras entregas de esta sección
La parodia a la obra "En busca del tiempo perdido" de Proust y al "Matadero" de Esteban Echeverría en el texto de Alejo Carpentier
Authors: Ortiz María Salvadora
Published: July 2018

La parodia es uno de los elementos constitutivos más destacados en al escritura Carpenteriana. Este artículo trata de demostrar la importancia de este recurso, utilizado por Carpentier para establecer relaciones más allá tiempo y espacio, entre dos realidades análogas similares, uno de los cuales se explican en términos de su afinidad a la otra, que bien puede haber ocurrido siglos antes.Parody is among the most salient constitutive elements in Carpenterian writing. This article attempts to demonstrate the significance of this resource, used by Capentier to establish relationships beyond time and space, between two similar, analogous realities, one of which is explained in terms of its affinity to the other, which may well have occurred centuries before.