bluuebunny/crossref_metadata_2025 huggingface dataset:
Infection within 2 weeks before liver transplantation closely related to prognosis of posttransplant infection: a single-center retrospective observational study in China
Authors: Ying Yue , Li Rui-Dong , Ai Jing-Wen , Zhu Yi-Min , Zhou Xian , Qian Yi-Yi , Chen Xin-Chang , Wang Xu-Yang , Zhang Hao-Cheng , Li Yang , Weng Shan-Shan , Yu Yi-Qi , Tao Yi-Feng , Zhang Xiao-Fei , Huang Yu-Xian , Wang Zheng-Xin , Zhang Wen-Hong
Published: May 2019

Background

Infections still represent the main factors influencing morbidity and mortality following liver transplantation. This study is to evaluate the incidence and risk factors for infection and survival after liver transplantation.

Methods

We retrospectively examined medical records in 210 recipients who underwent liver transplantation between April 2015 and October 2017 in our center.

Results

During the median follow-up days of 214, the incidence of infection after liver transplantation was 46.7% (n=98): namely, pneumonia (43.4%), biliary tract infection (21.9%) and peritonitis (21.4%). Among the pathogens in pneumonia, the most frequently isolated was Acinetobacter baumanii (23.5%) and Klebsiella pneumoniae (21.1%). For biliary tract infection, the first rank was Strenotrophomonas maltophilia (14.0%) and then Klebsiella pneumoniae (11.6%). Pseudomonas aeruginosa, Strenotrophomonas maltophilia, and Klebsiella pneumoniae accounted for 21.4%, 11.9% and 11.9% of pathogens in peritonitis, respectively. The independent risk factors for infection after liver transplantation are model for end-stage liver disease (MELD) or pediatric end-stage liver disease (PELD) score, total blood loss in operation and duration of drainage tube. All-cause mortality was 11.0% (n=23). The prognostic factors for postoperative infection in transplant recipients are infection, especially pneumonia within 2 weeks before transplantation, complication with impaired renal function and higher MELD or PELD score after 7 days of transplantation. Kaplan–Meier curves of survival showed that recipients with infection within 2 weeks before transplantation had a significantly lower cumulative survival rate compared with those without infection (66.7% vs 91.9%, HR=4.480, 95% CI, 3.377-47.85; p<0.001).

Conclusions

Infection, especially pneumonia within 2 weeks before transplantation are independent prognostic factors for postoperative infection in transplant recipients.
Variable versus constant frequency deep brain stimulation in patients with advanced Parkinson’s disease: study protocol for a randomized controlled trial
Authors: Jia Fumin , Zhang Jianguo , Liang Zhanhua , Liu Weiguo , Wang Xuelian , Liu Yiming , Guo Yi , Ling Zhipei , Cai Xiaodong , Wu Xi , Tao Yingqun , Wu Jianjun , Lv Wen , Xu Xin , Li Nan , Zhang Wenbin , Li Luming
Published: May 2019

Background: Deep brain stimulation (DBS) targeting the subthalamic nucleus (STN) can be used to treat motor symptoms and dyskinesia in the advanced stages of Parkinson’s disease (PD). High frequency stimulation (HFS) of the STN can lead to consistent, long-term improvement of PD symptoms. However, the effects of HFS on the axial symptoms of PD, specifically freezing of gait (FOG), can be limited or cause further impairment. While this can be alleviated via relatively low frequency stimulation (LFS) in select patients, LFS does not control all motor symptoms of PD. Recently, the National Engineering Laboratory for Neuromodulation reported preliminary findings regarding an efficient way to combine the advantages of HFS and LFS to form variable frequency stimulation (VFS). However, this novel therapeutic strategy has not been formally tested in a randomized trial.
Methods/Design: We propose a multicenter, double blind clinical trial involving 12 study hospitals and an established DBS team. The participants will be divided into a VFS and a constant frequency stimulation (CFS) group. The primary outcome will be changes in Stand-Walk-Sit (SWS) task scores at three months of treatment in the “medication off” condition. Secondary outcome measures include specific item scores on the Freezing of Gait Questionnaire and quality of life. The aim of this trial is to investigate the efficacy and safety of VFS compared with CFS.
Discussion: This is the first randomized controlled trial to comprehensively evaluate the effectiveness and safety of VFS of the STN in patients with advanced PD. VFS may represent a new option for clinical treatment of PD in the future.
Trial registration: The present protocol is registered at ClinicalTrials.gov: NCT03053726.
Conditions for fully gapped topological superconductivity in topological insulator nanowires
Authors: de Juan Fernando , Bardarson Jens H , Ilan Roni
Published: May 2019

Among the different platforms to engineer Majorana fermions in
one-dimensional topological superconductors, topological insulator
nanowires remain a promising option. Threading an odd number of flux
quanta through these wires induces an odd number of surface channels,
which can then be gapped with proximity induced pairing. Because of the
flux and depending on energetics, the phase of this surface pairing may
or may not wind around the wire in the form of a vortex. Here we show
that for wires with discrete rotational symmetry, this vortex is
necessary to produce a fully gapped topological superconductor with
localized Majorana end states. Without a vortex the proximitized wire
remains gapless, and it is only if the symmetry is broken by disorder
that a gap develops, which is much smaller than the one obtained with a
vortex. These results are explained with the help of a continuum model
and validated numerically with a tight binding model, and highlight the
benefit of a vortex for reliable use of Majorana fermions in this
platform.
Experimental investigation of water quality responses to inorganic pollutants for the establishment of a contamination warning system
Authors: Yoon Sukmin , Kim Seong-Su , Park No-Suk
Published: May 2019

In this study, batch and simulated pipeline experiments were conducted to investigate the response of water quality parameters (pH, conductivity, residual chlorine, turbidity, total organic carbon, UV 254, and oxidation reduction potential (ORP)) to various concentrations of four inorganic pollutants (Cd, Cr, Mn, and Pb). In addition, the possibility of detecting incidents of contamination in the actual water supply system was evaluated by deriving the response intensities of each factor to the concentrations of the pollutants. As a result, pH and ORP were identified as the major water quality parameters responsive to the four inorganic pollutants in this study. The responses were more intense (more sensitive) in pure water than in tap water. The results of the batch and simulated pipeline experiments for tap water showed almost identical tendencies, except for the second level of Mn injection (concentration 0.5 mg/L).
O declínio populacional das abelhas: causas, potenciais soluções e perspectivas futuras
Authors: BERINGER Juliana
Published: May 2019

A maioria das Angiospermas necessitam do processo de polinização para desenvolver frutos e sementes. As principais polinizadoras e mais eficientes são as abelhas, porém essas estão sofrendo um declínio populacional cada vez maior, devido a vários fatores e causando inúmeras consequências. Sendo assim, o objetivo deste artigo é expor as causas e consequências do desaparecimento das abelhas e apresentar alternativas visando solucionar esse problema. A partir das informações obtidas e analisadas na presente revisão, foi possível constatar que os desmatamentos, as queimadas, a urbanização, o manejo inadequado, as variações climáticas, os agentes patogênicos, as ondas magnéticas, as monoculturas e os agrotóxicos são relevantes como agentes causais no processo de desaparecimento das abelhas, levando a uma série de consequências, incluindo destruição do habitat, falta de recursos florais, estresse das abelhas, doenças (Varroatose, Nosemose e CCD), comprometendo na fisiologia, no comportamento e na estrutura social das abelhas. Na tentativa de minimizar ou evitar esse problema, foram propostas soluções alternativas, através da adoção de medidas como modificação e redução do uso dos agrotóxicos, conservação do habitat mantendo a agrobiodiversidade, manejo adequado das colmeias e uso sustentável das colônias, aprimoramento do conhecimento dos polinizadores para o seu uso adequado, educação ambiental com a população de apicultores, meleiros e agricultores, e a possibilidade de introdução de espécies exóticas com ampla distribuição geográfica e generalista, podendo vir a constituírem importantes estratégias visando aplicação futura.
Biomarcadores da tuberculose: uma revisão da literatura.
Authors: SOUZA William Machado de , HERMES Djuli Milene
Published: May 2019

A tuberculose é uma infecção micobacteriana comumente causada pelo agente etiológico Mycobacterium tuberculosis, podendo também ser desencadeada por outras bactérias do gênero Mycobacterium. Ainda que bem documentada, mais de um século após sua descoberta, situa-se como a doença infecciosa que mais mata no mundo. Configura-se também problema socioeconômico importante, atingindo em especial as camadas mais pobres da população e comprometendo seriamente sua capacidade produtiva. Os métodos diagnósticos tradicionais para a doença consistem da baciloscopia e cultura, recentemente adotando os testes moleculares rápidos, todos com limitações significativas, como a incapacidade de discriminar entre casos de tuberculose ativa e latente, sensibilidade inconsistente e incapacidade de oferecer prognósticos. A presente revisão da literatura procurou elucidar os atuais avanços na pesquisa de biomarcadores da infecção nos últimos 5 anos com o emprego da metodologia ELISA. Foram verificadas e comparadas evidências apresentadas pelos estudos e as performances diagnósticas alcançadas em cada contexto. Constatou-se uma evidente heterogeneidade nas respostas imunológicas entre populações e indivíduos, provável fruto da diversidade genética do patógeno que possui linhagens intercontinentais e regionais, bem como diferenças particulares nas expressões de alguns biomarcadores, seja por variáveis genéticas ou mesmo outras doenças de base; a homologia dos antígenos pesquisados com outras espécies de bactérias também foi uma problemática. Fica claro que questões genéticas particulares de populações e do próprio agente infeccioso precisam ser melhor consideradas nesses estudos, a fim de alcançar um perfil sorológico suficientemente sensível e específico para triagem clínica e diagnóstico destes pacientes.
Por que os produtores rurais adotam e abortam a participação no Modelo de Excelência da Gestão (MEG) em suas propriedades?
Authors: RAMOS Carina Da Cruz
Published: May 2019

No cenário da agropecuária brasileira há uma competitividade de mercado, a qual exige do produtor rural organização e eficiência em sua propriedade. É interessante encarar as médias e grandes propriedades rurais como uma empresa. E como tal, adotar uma ferramenta de gestão que auxilie o produtor rural a gerenciar o seu negócio, buscando vantagens no mercado e gerando maior rentabilidade. O Brasil tem a sua base econômica na agropecuária. Portanto, é de grande importância pesquisar os motivos pelos quais os produtores rurais adotam e, em seguida, abortam a utilização do Modelo de Excelência em Gestão (MEG) em suas propriedades. Também devido à necessidade de o produtor rural ter em sua propriedade instrumentos de gestão adequado a cada setor da mesma. O objetivo principal deste trabalho é analisar qualitativamente os motivos pelos quais os produtores rurais adotam e abortam o MEG em suas propriedades. A presente pesquisa foi realizada através de estudo de caso exploratório descritivo na Agropecuária Renato Arns e Ruviaro Agropecuária, que foram escolhidas por possuírem o Termo de Adesão do Programa Gaúcho da Qualidade e Produtividade (PGQP) e estarem inativas nas autoavaliações do Sistema de Avalição da Gestão (SAG) nos anos de 2014 a 2017, todas já participaram dos SAG’s dos anos anteriores. Os resultados da pesquisa mostraram que as agropecuárias adotaram o MEG em busca de melhores resultados nos processos gerenciais a fim de diminuir os custos, aumentar a produtividade e, consequentemente, aumentar a rentabilidade das mesmas. Concluiu-se ainda que o principal benefício dos produtores rurais utilizarem o programa em suas propriedades rurais é terem uma visão sistêmica da gestão organizacional. Quanto ao fato de abortarem as atividades do programa, os motivos foram diferentes, sendo uma por motivo de encerramento das atividades no Brasil, enquanto que a outra, por não conseguir dar prioridade ao programa, não alcançou os resultados esperados e acabou abandonando o mesmo.
Efeito da carga de gemas da videira ‘Sauvignon Blanc’ na intensidade de antracnose (Elsinoe ampelina)
Authors: WÜRZ Douglas André , BONIN Bruno Farias , ALLEBRANDT Ricardo , DE BEM Betina Pereira , CANOSSA Adrielen Tamiris , REINEHR Juliana , RUFATO Leo , BRIGHENTI Alberto Fontanella , KRETZSCHMAR Aike Anneliese
Published: May 2019

O objetivo deste trabalho avaliar o efeito do aumento do número de gemas na intensidade de antracnose na videira ‘Sauvignon Blanc’ cultivada em região de elevada altitude de Santa Catarina. Os tratamentos consistiram em quatro diferentes cargas de gemas deixas na poda invernal: 15 gemas/planta, 30 gemas/planta, 50 gemas/planta e 75 gemas/planta. Os dados foram submetidas à análise de variância (ANOVA) e quando detectadas efeitos de tratamento, procedeu-se o teste de comparação de médias pelo teste Tukey a 5% de probabilidade de erro. O número de gemas por planta influenciou a incidência e severidade de antracnose nas folhas e ramos da videira Sauvignon Blanc, observando-se que plantas podadas com 75 gemas por planta apresenta maior intensidade de antracnose, enquanto, plantas podadas com 15 gemas, observou-se menor intensidade de antracnose nas folhas e ramos da videira Sauvignon Blanc.
Molecular Mechanisms of Epigenetic Regulators as Activatable Targets in Cancer Theranostics
Authors: Li Yinglu , Li Zhiming , Zhu Wei-Guo
Published: May 2019

Epigenetics is defined as somatically inheritable changes that are not accompanied by alterations in DNA sequence. Epigenetics encompasses DNA methylation, covalent histone modifications, non-coding RNA as well as nucleosome remodeling. Notably, abnormal epigenetic changes play a critical role in cancer development including malignant transformation, metastasis, prognosis, drug resistance and tumor recurrence, which can provide effective targets for cancer prognosis, diagnosis and therapy. Understanding these changes provide effective means for cancer diagnosis and druggable targets for better clinical applications. Histone modifications and related enzymes have been found to correlate well with cancer incidence and prognosis in recent years. Dysregulated expression or mutation of histone modification enzymes and histone modification status abnormalities have been considered to play essential roles in tumorigenesis and clinical outcomes of cancer treatment. Some of the histone modification inhibitors have been extensively employed in clinical practice and many others are still under laboratory research or pre-clinical assessment. Here we summarize the important roles of epigenetics, especially histone modifications in cancer diagnostics and therapeutics, and also discuss the developmental implications of activatable epigenetic targets in cancer theranostics.
Enzyme-Instructed Self-assembly in Biological Milieu for Theranostics Purpose
Authors: Huang Zhentao , Yao Qingxin , Wei Simin , Chen Jiali , Gao Yuan
Published: May 2019

Precision medicine is in an urgent need for public healthcare. Among the past
several decades, the flourishing development in nanotechnology significantly advances
the realization of precision nanomedicine. Comparing to well-documented nanoparticlebased
strategy, in this review, we focus on the strategy using enzyme instructed selfassembly
(EISA) in biological milieu for theranostics purpose. In principle, the design of
small molecules for EISA requires two aspects: (1) the substrate of enzyme of interest;
and (2) self-assembly potency after enzymatic conversion. This strategy has shown its irreplaceable
advantages in nanomedicne, specifically for cancer treatments and Vaccine
Adjuvants. Interestingly, all the reported examples rely on only one kind of enzymehydrolase.
Therefore, we envision that the application of EISA strategy just begins and
will lead to a new paradigm in nanomedicine.
Preliminary Study on the Mechanism of Carvacrol Regulating Hepatocellular Carcinoma Based on Network Pharmacology
Authors: Li Sha , Zhao Haixia , Bao Lidao
Published: May 2019

Objective:

To predict and analyze the target of anti-Hepatocellular Carcinoma (HCC) in
the active constituents of Safflower by using network pharmacology.

Methods:

The active compounds of safflower were collected by TCMSP, TCM-PTD database and
literature mining methods. The targets of active compounds were predicted by Swiss Target Prediction
server, and the target of anti-HCC drugs was collected by DisGeNET database. The target was
subjected to an alignment analysis to screen out Carvacrol, a target of safflower against HCC. The
mouse HCC model was established and treated with Carvacrol. The anti-HCC target DAPK1 and
PPP2R2A were verified by Western blot and co-immunoprecipitation.

Results:

A total of 21 safflower active ingredients were predicted. Carvacrol was identified as a possible
active ingredient according to the five principles of drug-like medicine. According to Carvacrol's
possible targets and possible targets of HCC, three co-targets were identified, including cancer-
related are DAPK1 and PPP2R2A. After 20 weeks of Carvacrol treated, Carvacrol group significantly
increased on DAPK1 levels and decreased PPP2R2A levels in the model mice by Western
blot. Immunoprecipitation confirmed the endogenous interaction between DAPK1 and PPP2R2A.

Conclusion:

Safflower can regulate the development of HCC through its active component Carvacrol,
which can affect the expression of DAPK1 and PPP2R2A proteins, and the endogenous interactions
of DAPK1 and PPP2R2A proteins.
Improving Value Through Heart Failure Care Coordination: The Allina Health Experience
Authors: Bradley Steven M. , Rush Pam , Wolf Kim , Rahmatullah Amin , Braun Robin , Samara Michael , Bank Alan J. , Bergeson Steven , Gunderson Wendy , Strauss Craig E. , Witt Shaina , Hutchinson Melissa , Tong TC , Mueller Denise , Eckman Peter , Kubo Spencer H.
Published: May 2019

Reducing readmission following heart failure is emerging as a target of quality initiatives in the Centers for Medicare & Medicaid Services Hospital Readmission Reduction Program. In response to higher readmission rates than desired following heart failure (HF) hospitalization, Allina Health hospital's cardiovascular subspecialty care developed an HF nurse care coordinator program to reduce readmissions. The nurse HF care coordinator serves as the bridge to help manage care following hospital discharge and ensure adherence to protocols developed by the HF management program. This effort was initially developed and implemented at Mercy and Unity Hospital and was associated with a 4.3% reduction in HF readmissions. Subsequent expansion of the HF nurse care coordinator program to United and Abbott Northwestern Hospitals was associated similar reductions in HF readmissions. Concurrently, all-cause mortality at 6 months post-discharge was also significantly lower following implementation of the program (mortality pre-HF care coordinator program 12.6% vs. post-HF care coordinator program 18.8%, P = .047) in propensity matched analysis. The findings of this effort suggest the potential for care coordination programs to improve the care and outcomes of patients with HF.
A Web-Based Clinical System for Cohort Surveillance of Specific Clinical Effectiveness and Safety Outcomes: A Cohort Study of Non–Vitamin K Antagonist Oral Anticoagulants and Warfarin
Authors: Lin Fong-Ci , Huang Shih-Tsung , Shang Rung Ji , Wang Chi-Chuan , Hsiao Fei-Yuan , Lin Fang-Ju , Lin Mei-Shu , Hung Kuan-Yu , Wang Jui , Shen Li-Jiuan , Lai Feipei , Huang Chih-Fen
Published: May 2019

Background

Conventional systems of drug surveillance lack a seamless workflow, which makes it crucial to have an active drug surveillance system that proactively assesses adverse drug events.

Objective

The aim of this study was to develop a seamless, Web-based workflow for comparing the safety and effectiveness of drugs in a database of electronic medical records.

Methods

We proposed a comprehensive integration process for cohort surveillance using the National Taiwan University Hospital Clinical Surveillance System (NCSS). We studied a practical application of the NCSS that evaluates the drug safety and effectiveness of novel oral anticoagulants (NOACs) and warfarin by cohort tree analysis in an efficient and interoperable platform.

Results

We demonstrated a practical example of investigating the differences in effectiveness and safety between NOACs and warfarin in patients with nonvalvular atrial fibrillation (AF) using the NCSS. We efficiently identified 2357 patients with nonvalvular AF with newly prescribed oral anticoagulants between 2010 and 2015 and further developed 1 main cohort and 2 subcohorts for separately measuring ischemic stroke as the clinical effectiveness outcome and intracranial hemorrhage (ICH) as the safety outcome. In the subcohort of ischemic stroke, NOAC users exhibited a significantly lower risk of ischemic stroke than warfarin users after adjusting for age, sex, comorbidity, and comedication in an intention-to-treat (ITT) analysis (P=.01) but did not exhibit a significantly distinct risk in an as-treated (AT) analysis (P=.12) after the 2-year follow-up. In the subcohort of ICH, NOAC users did not exhibit a different risk of ICH both in ITT (P=.68) and AT analyses (P=.15).

Conclusions

With a seamless and Web-based workflow, the NCSS can serve the critical role of forming associations between evidence and the real world at a medical center in Taiwan.
The Use of and Experiences With Telelactation Among Rural Breastfeeding Mothers: Secondary Analysis of a Randomized Controlled Trial (Preprint)
Authors: Kapinos Kandice , Kotzias Virginia , Bogen Debra , Ray Kristin , Demirci Jill , Rigas Mary Ann , Uscher-Pines Lori
Published: May 2019

BACKGROUND

Telelactation services connect breastfeeding mothers to remotely located lactation consultants through audio-visual technology and can increase access to professional breastfeeding support in rural areas.

OBJECTIVE

The objective of this study was to identify maternal characteristics associated with the demand for and use of telelactation and to describe visit characteristics.

METHODS

We conducted a descriptive study within the context of a randomized controlled trial. Participant survey data and vendor electronic medical record data were used to assess video call characteristics like timing, duration, topics discussed, and participant satisfaction. Recruitment occurred from 2016-2018 at a rural critical access hospital in Pennsylvania. The 102 women enrolled in the study were given access to unlimited, on-demand video calls with lactation consultants through a mobile phone app and were tracked for 12 weeks following their postpartum hospitalization.

RESULTS

A total of 94 participants out of 102 recruits (92%) participated in the final, 12-week survey assessment were included in the analysis. Of those, 47 (50%) participants reported participating in one or more video calls, and 31 (33%) completed one or more calls that included a substantive discussion of a breastfeeding challenge. Participants who used telelactation (21/31, 68%; P=.02) were more likely to be working at 12 weeks postpartum compared to others (26/63, 41%), were less likely (12/31, 39%; P=.02) to have prior breastfeeding experience on average compared to nonusers (41/63, 65%), and were less likely to have breastfed exclusively (16/31, 52%; P<.001) prior to hospital discharge compared to mothers who didn’t use telelactation services (51/63, 81%). Most video calls (58/83, 70%) occurred during the infant’s first month of life and 41% (34/83) occurred outside of business hours. The most common challenges discussed included: breast pain, soreness, and infection (25/83, 30%), use of nipple shields (21/83, 25%), and latch or positioning (17/83, 24%). Most telelactation users (43/47, 91%) expressed satisfaction with the help received.

CONCLUSIONS

Telelactation is an innovation in the delivery of professional breastfeeding support. This research documents both demand for and positive experiences with telelactation in an underserved population.

CLINICALTRIAL

ClinicalTrials.gov NCT02870413; https://clinicaltrials.gov/ct2/show/NCT02870413
Exploring Patient Needs in Online Health Communities Using Text Mining--Taking Diabetes and Depression as Examples (Preprint)
Authors: Liu Jingfang , Jiang Xiaoyan , Zhang Wei , Zhou Yingyi
Published: May 2019

BACKGROUND

Online Health Community (OHC) refers to a forum where patients, their family members, doctors and caregivers communicate with each other. Patients who participate in OHCs can obtain benefits for disease treatments and health management, so identifying the categories of patient needs and how they are satisfied are significant to determining theories of patient demand and community construction.

OBJECTIVE

(1) Explore the needs of patients in the Internet environment. (2) Distinguish the similarities and differences of patient needs among OHCs of different types and concerning different diseases. (3) Proposed a method for automatically identifying patient demands in Internet environments.

METHODS

This study used a combination of manual annotation and computer-aided method to mine value of 9936 posts collected from four OHCs in China. On one hand, we recruited 7 diabetes or depression medical experts to label text according to a theoretical framework, forming patient need theory in Internet environments, which is designed for the first two research goals. On the other hand, based on the corpus constructed by manual annotation, this research used Natural Language Processing (NLP) and Machine Learning (ML) to train a model for automatically identifying patient demands, which is planned to reach the third research purpose.

RESULTS

According to statistical results, the proportion of posts related to patient needs in OHCs was approximately 91%, and posts concerned with Emotional Support (18%), Information (28%) and Socialization (44%) needs were the top three most prevalent categories. However, when OHCs were divided according to user composition and disease type, patient needs were diverse: the chief demand was Socialization in Patient Interaction OHCs (65%), Diabetes OHCs (50%), and Depression OHCs (69%), while Information (96%) was the chief demand in Patient-Doctor Interaction OHCs. A model was trained to identify patient needs taking Linguistic Features (LF) and Category Keyword Features (CKF) as input and Random Forest as the classifier, of which the F1 value was higher than 0.80 on test set.

CONCLUSIONS

Patient needs in the Internet environment mainly include Emotional Support needs, Information needs and Socialization needs. Differences in community type and disease type can lead to diverse patient needs in OHCs. It is practical to use computer-aided methods to identify patient needs in OHCs automatically.
Investigating the Impact of Airport Relocation on the Transport Network in Special Region of Yogyakarta, Indonesia
Authors: Fitrada Andrean Gita
Published: May 2019

Adi Sutjipto International Airport is the airport currently operated in Special Region of Yogyakarta (SRY), located near the city centre area. SRY needs to construct a new airport due to the increase in air passengers. The proposed airport, named New Yogyakarta International Airport (NYIA) is located in the undeveloped area, away from the city centre. This study is aimed to investigate the impact of airport relocation to the road network and to assess several developments of transportation infrastructures to the new airport.  The analysis was conducted by developing a transport network model using PTV Visum. The secondary data collected from the local government to develop the transport network model, including the development of origin-destination matrices and forecasting purpose.  The scenarios of road infrastructures development and new rail service to the airport in 2025 are then modelled. The results showed that the road infrastructure developed can reduce the number of congested main roads from 9.47% into 5.94%. Rail service to the airport is effective to decrease the traffic congestion at two NYIA roads access and able to increase their average speed from 49.45 and 44.29 km/h into 66.45 and 62.66 km/h.
Strength Evaluation of Reinforced Concrete Structure for Regular Building due to Earthquake Load Based on Different Soil Types
Authors: Tanijaya Jonie
Published: May 2019

Earthquakes are natural events caused by tectonic plate movements and it is unpredictable. Thus, the building design regulation has an important role in ensuring the Earthquake resistant structure. A commonly used method is the response spectrum method. For different soil types, the value of the design spectra may increase or decrease. Therefore this study aims to determine the effect of soil type on the strength of reinforced concrete structures, especially the building behavior and structural internal forces. Analysis results show that the increase of base-shear value of Makassar is about 34% and 103% for medium soil and soft soil condition compared to hard soil. The increase of beam negative moment is about 27% to 39% in soft soil compared to hard soil, while the value is about 8% to 14% in medium soil compared to hard soil. The increase of beam positive moment varies considerably between 8% to 50%. The increasing moment is directly proportional to the required reinforcement area of the beam. Demand capacity ratio of column has also increased about 10% to 35% for medium soil and soft soil compared to hard soil.
Comparison of the Use of Cement, Gypsum, and Limestone on the Improvement of Clay through Unconfined Compression Test
Authors: Hastuty Ika Puji
Published: May 2019

Soil stabilization is an effort to improve soil properties by adding additives in the soil to increase the soil strength and maintain the shear strength of the soil. There are many materials which can be used as stabilizers. The materials used in this study were cement, gypsum, and limestone, then the compressive strength values were compared by using the Unconfined Compression Test (UCT). The mixture combinations used in this study were 1% to 10% of cement, gypsum, and limestone on clay by curing for 14 days. The compressive strength value resulted from the unconfined compression test on the original soil sample was 1.4 kg/cm2. The original soil was classified as moderately sensitive soil because the sensitivity value of the original soil was 2. After being stabilized with various mixtures of cement, gypsum, and limestone, soil stabilization using cement obtained the maximum unconfined compressive strength value is 3.681 kg/cm2 in the mixture of 10%. Similarly, the soil stabilization using limestone and gypsum also obtained its maximum unconfined compressive strength value in the mixture of 10% is 3.307 kg/cm2 and 2.975 kg/cm2, respectively.
The Effects of Water to Solid Ratio, Activator to Binder Ratio, and Lime Proportion on the Compressive Strength of Ambient-Cured Geopolymer Concrete
Authors: Adam Andi Arham
Published: May 2019

Low calcium fly ash based Geopolymer has been proven to be one of the potential alternatives substitutes to Portland Cement not only due to its high resistance to chemical attack but also because of the vast availability of class F fly ash for raw materials. However, one of the limitations of geopolymer as the alternative binders in concrete is that the strength develops slowly under ambient condition. This paper presented the investigation of water to solid ratio, activator to binder ratio, and lime proportion on the compressive strength of ambient-cured geopolymer concrete. To develop sufficient strength at an early age, class F fly ash and slaked lime (Ca (OH)2) were used as the binder with the proportion of lime to binder of 4%, 5%, 6%, and 7%. The blended binder was activated by sodium silicate and sodium hydroxide solution with the variation of activator to binder ratio of 0.45, 0.5, 0.55, and 0.6.  The water to solid ratio of 0.30, 0.31, 0.32, and 0.33 was chosen to facilitate good workability which was done by adding water to the mix. The compressive strength tests were conducted at 7, 14, and 28 days on the cylindrical concrete specimens with a dimension of 100 mm diameter and 200 mm height. The results show that the activator to binder ratio of 0.50 to 0.55, and the proportion of lime to the binder of 6% to 7% were the optimum range value. It was also found that the lower the water to cement ratio the higher the compressive strength and the water to solid ratio as low as 0.3 produced the highest compressive strength while still maintaining good workability.
EN LA CUERDA FLOJA: EXPERIENCIAS RELACIONADAS CON LA HIGIENE MENTAL EN EL ESTUDIANTADO DE ENFERMERÍA DE LA FES IZTACALA
Authors: Tenorio Mendoza Stephania , Álvarez Castro Mario Alberto , García Martínez María De Lourdes , González González Giovana , Gutiérrez Alina , Pacheco Moreno Felipe Alejandro
Published: May 2019

La higiene mental proviene a partir de la separación y clasificación del concepto de salud mental, especificando que es un conjunto de actividades que el ser humano necesita para estar en equilibrio biopsicosocial. La higiene mental en los estudiantes de enfermería de la FES-Iztacala, es interrumpida por el estrés al que son sometidos durante su desarrollo académico. Objetivo: Analizar las experiencias de estudiantes universitarios relacionadas con la higiene mental, en los módulos clínicos. Metodología:Investigación cualitativa, descriptiva. Para la

recolección de datos se llevó a cabo una entrevista semiestructurada y se utilizó una guía de preguntas relacionadas con el objeto de estudio, misma que fue grabada, participaron cuatro mujeres y dos hombres estudiantes de Enfermería, el análisis se llevó a cabo de acuerdo a los pasos propuestos por Krugger. Hallazgos: Se detectaron cuatro categorías: vivencias, sentimientos, emociones, problemas de salud y alteraciones en las relaciones interpersonales. Conslusión: Durante los módulos clínicos las actividades de higiene mental realizadas por las y los estudiantes disminuyeron o fueron nulas, afectando directamente en el estado físico y emocional.

Palabras clave: Higiene metal, experiencias, problemas de salud.
CUIDADOS DE ENFERMERÍA EN UNA FAMILIA CON ENFERMEDADES CRÓNICAS
Authors: Elías Viramontes Alma De Coral , González Mantilla Fabiola , González Juárez Liliana , Flores Mora Luis Fernando , Brito Carbajal Carlos Emmanuel
Published: May 2019

Estudio de caso familiar de enfoque cualitativo,

el cual se realizó en una familia que habita en la

ciudad de México, de enero a mayo del 2015, bajo

la metodología del Proceso Atención de Enfermería.

Para la valoración, se utilizó el Modelo Calgary e

instrumentos que permitieron detectar alteraciones

de salud en los procesos familiares y en el rol del

cuidador; se identificaron las necesidades de salud

presentes, para lo cual se utilizó la taxonomía

de diagnósticos NANDA, posteriormente se

aplicaron intervenciones de enfermería basadas en

evidencia, obteniéndose resultados favorables en

la comunicación y relación familiar; apoyando en

el desarrollo individual y dando las herramientas

necesarias para resolver las adversidades que se

vayan presentando en el día a día.
FLORENCE NIGHTINGALE, PIONERA EN EL MODELO DE GESTIÓN
Authors: Martínez Tovar Alejandra , Rojas Cartillo Xochitl , Rosas Vargas Laura , Zárate Grajales Rosa Amarilis , Flores Mora Luis Fernando
Published: May 2019

La obra de Florence Nightingale está

estrechamente relacionada con su orientación

filosófica sobre la interacción del paciente con su

entorno. Al revisar desde un contexto actual las

acepciones que aporta Florence Nightingale en

su principal obra Notas de Enfermería: Qué es y

qué no es, sugieren un acercamiento a los actuales

modelos de calidad y seguridad del paciente. En

su obra incluye conceptos de calidad en el cuidado

al considerar aspectos como la higiene, entorno,

alimentación y cuidado del paciente; convirtiéndose

así en la enfermera pionera de la gestión.
Medicina Alternativa y Complementaria: ¿Qué experiencias tienen las personas al utilizarla?
Authors: Velasco Lozano Edwin Alexis , Gusman Morales Eduardo , Ordoñez Monroy Ana Lorena , Torres Razo Daniel , De la Garza Castañón Nohemí , Álvarez Martínez Christopher , Guillén Cadena Dulce María
Published: May 2019

Introducción: El incremento del uso de la Medicina Alternativa y Complementaria (MAC) se puede sustentar en la eficacia reportada y escasos efectos secundarios. Sin embargo, no hay suficientes investigaciones sobre posibles complicaciones e interacciones con los medicamentos convencionales. Objetivo: Describir las experiencias de mujeres que hayan utilizado la medicina alternativa y complementaria Metodología: Investigación cualitativa con diseño fenomenológico descriptivo. La recolección de datos se realizó a través de entrevistas a profundidad, con una guía que incluyó los temas relacionados con el fenómeno a investigar, observación y notas. El análisis se realizó según lo propuesto por Krueger: lectura, transcripción, codificación, formación de temas y sub temas, se aplicaron los criterios de rigor y el consentimiento informado. Hallazgos: Se encontró que los principales motivos por los cuales las entrevistadas acudieron a la medicina alternativa fueron por recomendación de familiares o conocidos así como la asequibilidad de la misma. Las entrevistadas admiten utilizar 1 o más métodos alternativos, de los cuales sobresale la herbolaria, para tratar patologías específicas y/o síntomas generales. Sobre sus emociones y sentimientos que les causó el uso de la MAC sobresalen la confianza y bienestar que les genera. También se identificó una creencia sobre la inocuidad de los remedios herbolarios ya que creen que son inofensivos. Conclusiones: La experiencia de las participantes con la MAC fue en lo general positiva y ninguna reportó efectos secundarios por el uso de la misma. Por esta sensación de bienestar percibida, las personas tienen una gran confianza en sus efectos sanadores. 
Korelasi kepadatan nyamuk Anopheles spp. terhadap faktor-faktor meteorologi di Desa Sungai Nyamuk, Kabupaten Nunukan, Kalimantan Utara
Authors: Sugiarto Sugiarto , Hadi Upik Kesumawati , Soviana Susi , Hakim Lukman
Published: May 2019

Korelasi antara angka menggigit Anopheles (man biting rate-MBR) dengan faktor-faktor meteorologi sangat penting untuk mengantisipasi fluktuasi kejadian malaria. Penelitian ini bertujuan untuk menganalisis korelasi kepadatan Anopheles spp. dengan faktor-faktor meteorologi di Desa Sungai Nyamuk, daerah endemis malaria di Kalimantan Utara. Kepadatan nyamuk Anopheles spp. didapatkan dari umpan orang (human landing collection-HLC) (pengamatan 18.00-06.00). Pearson Product Moment Test digunakan untuk menganalisis korelasi antara angka menggigit Anopheles (MBR) dengan faktor-faktor meteorologi. Hasil penelitian menunjukkan bahwa curah hujan mempunyai hubungan bermakna dengan kepadatan Anopheles (MBR), sedangkan kepadatan Anopheles mempunyai hubungan bermakna dengan kejadian  malaria. Suhu udara dan kelembaban tidak mempunyai hubungan bermakna dengan kepadatan Anopheles (MBR). Curah hujan dapat dijadikan sebagai salah satu indikator dalam penerapan sistem kewaspadaan dini untuk mengantisipasi fluktuasi kejadian kasus malaria.
An Overview of Microfilariae on Patients who have received treatment in Batuah Village, Kotawaringin Timur District 2015
Authors: Nurmansyah Dian , Fahmi Muhammad , Rifqoh Rifqoh , Puspawati Puspawati , Sari Putri Kartika , Arsyad Muhammad , Astuti Aldiana
Published: May 2019

Filariasis is a chronic infectious disease, caused by filarial worms in the lymph and lymph nodes cause lymphangitis and elephantiasis. Batuah Village is the area in Sampit with the largest percentage of microfilariae compared to the surrounding area. From 196 the number of Batuah villagers examined by the filariasis elimination officer of Kotawaringin Timur District Health Office in 2013 obtained 5 positive cases of filariasis with 2.55% microfilaria number which is dominated by filaria worm Brugia malayi. From the local health center has also conducted a mass drug treatment program with DEC medication, combined with albendazole for 12 days on 14-16 July 2014. The aim of this study was to determine the success rate of treatment conducted by the health officer against filariasis patients in the Batuah village. The method used in this microfilariae examination is a microscopic method. Capillary blood was taken on 4 filarial patients who tested positive on the previous examination who had been given DEC + Albendazole treatment, the result from 4 samples that examined 1 positive sample of 4 patients. The implementation of medication that has been done by public health office was successful because there was a decrease of microfilaria rate which was previously 2.55% to 0,51% (<1%).
Kejadian ulkus berulang pada pasien diabetes mellitus
Authors: Marissa Nelly , Ramadhan Nur
Published: May 2019

Ulkus diabetikum merupakan salah satu komplikasi diabetes mellitus (DM) yang paling sering terjadi. Lamanya seseorang menderita ulkus akan menyebabkan besarnya kejadian ulkus berulang. Tujuan penelitian ini adalah untuk megetahui kejadian ulkus berulang dan penilaian derajat keparahan ulkus pada penderita DM. Penelitian menggunakan metode potong lintang, dengan melibatkan 57 orang (40 orang dari RSUDZA dan 17 orang dari RSU Meuraxa) responden. Wawancara dilakukan untuk mendapatkan data kejadian ulkus berulang, berapa sering terjadinya ulkus, lokasi, waktu sembuh, mengikuti senam diabetes dan riwayat merokok. Selanjutnya dilakukan pengukuran berat dan tinggi badan untuk mendapatkan nilai indeks massa tubuh (IMT)dan penilaian derajat ulkus berdasarkan kriteria University of Texas (UT). Dari hasil penelitian didapatkan bahwa kejadian ulkus berulang sebesar 28 orang (49,1)%, kejadian ulkus berulang pada sebagian besar responden mencapai 2 kali, paling sering di ekstermitas bawah. Waktu yang diperlukan untuk sembuh terbanyak mulai berkisar dari harian sampai satu tahun. Kebanyakan dari penderita ulkus berulang tersebut tidak mengikuti senam diabetes, bukan perokok aktif, dan memiliki IMT lebih. Berdasarkan kriteria UT kejadian ulkus yang paling sering adalah luka yang sudah mencapai tulang atau sendi dengan kondisi yang iskemik dan infeksi
Cutaneous leishmaniasis and related tissue helminthiasis (review)
Authors: Akhmedova M. D. , Anvarov J. A. , Suvonkulov U. T. , Mirzajonova D. B. , Osipova S. O.
Published: May 2019

Epidemiology of cutaneous leismaniasis is considered, CL morbidity remains rather high and it is increasing in Uzbekistan. The main medicines in leishmaniasis treatment are pentavalent antimonials which are characterized by toxicity and resistance development, and amphotericin B. Amphotericin B is toxic too and has a lot of contraindications and side effects. Medicines with reparative and antioxidant properties are assumed to positively influence the CL course, not only leishmanicidal preparations. Protective immunity in CL mediated by Th1 response is analyzed. Expediency of examination of patients with CL for helminthiases inducing opposite Th2-response as well as studies of concomitant helminthiases influence on the CL course are discussed.
Platelets in invasive aspergillosis: role in pathogenesis and immune defense
Authors: Serebryanaya N. B. , Yakutseni P. P. , Klimko N. N.
Published: May 2019

Invasive aspergillosis (IA) is a serious disease, with mortality rate up to 80%. A. fumigatus is an angiovasive pathogen, fragments of its hyphae can detach and circulate in the bloodstream. Platelets are activated by surface structures, metabolites and soluble fungal complexes, resulting in adhesion to conidia and fungal hyphae. The melanin and hydrophobin contained in the conidia, as well as the galactosaminogalactan contained in the hyphae and the glyphotoxin secreted by the hyphae, suppress phagocytic cells, but activate the platelets. Activated platelets show direct antifungal activity by releasing microbicidal proteins and serotonin. In addition to direct antifungal effect, platelets form an interactive network with cellular components of the immune system and a complement system, increasing the response of neutrophils and monocytes. In the presence of platelets, the efficacy of antimycotics is greatly enhanced. The adverse effects of platelet activation in IA are associated with clinical conditions such as hemoptysis, pulmonary hemorrhage and infarctions of various organs. Another danger associated with IA is the development of thrombocytopenia. Thrombocytopenia is defined as an independent risk factor of mortality in IA in oncohematological patients after allogeneic transplantation of hematopoietic stem cells. Numerous evidences of the important role of platelets in protection from A. fumigatus suggest that the study of the number and functional state of platelets will provide a new data, which will help develop new methods for prediction and treatment of IA.
Prediction of severity of hemorrhagic fever with renal syndrome
Authors: Lyubushkina A. V. , Popova L. L. , Nedugov G. V. , Konstantinov D. Yu. , Stulova M. V.
Published: May 2019

The aim is to develop a method of early prediction of the severity of hemorrhagic fever with renal syndrome on the basis of clinical and laboratory data.

A comprehensive clinical and laboratory examination of 144 patients with hemorrhagic fever with renal syndrome was carried out in the period of 2–5 days from the onset of the disease. Based on the discriminant analysis of the data obtained, a discriminant model for predicting the severity of hemorrhagic fever with renal syndrome was developed. The index of accuracy of prognosis of clinical forms of the disease on the basis of the developed discriminant model is 97.4%.