bluuebunny/crossref_metadata_2025 huggingface dataset:
Preliminary Validation of the Rey 15-Item Test and Reliable Digit Span in Native Japanese Samples
Authors: Ryan Joseph J. , Yamaguchi Takahiro , Kreiner David S.
Published: August 2018

The Rey 15-Item Test and reliable digit span were evaluated in Japan. Participants were controls ( n = 15), healthy volunteers instructed to simulate memory impairment ( n = 12; 5 of 17 volunteers did not comply with instructions and were dropped), healthy elderly ( n = 12), and cognitively disabled nursing home residents ( n = 8). On the 15-Item Test, controls and elderly performed similarly and were combined. Nursing home residents could not cope with the 15-Item Test and were dropped. Total score was a fair predictor of dissimulation using a cutoff ≤ 8. Rows were fair predictors using a ≤2 cutoff. Sensitivities were low and specificities were excellent. Reliable digit span contrasts between simulators and each of the other groups demonstrated that reliable digit span discriminated controls and elderly from simulators (≤6 and ≤5 cutoffs). Sensitivities were moderate and specificities were excellent. Reliable digit span did not differentiate simulators from nursing home residents.
Bare Lives in the Shadow of Empires: Jesus, Comfort Women, and Theology of Resistance
Authors: Uk Lim Sung
Published: August 2018

This article delves into the biopolitical dimension of Jesus and Korean comfort women by engaging with the insight yet to be gleaned from Giorgio Agamben’s notion of bare life. Seen through this biopolitical prism, Jesus in the passion narratives of the Gospels can be understood as a paradigmatic bare life in his sheer ambiguity, which swings back and forth between terrestrial and celestial dominions. Similarly, Korean comfort women, albeit in a different historical and sociocultural context, can also be viewed as bare lives under ruthless Japanese colonial rule (1910–1945). My contention here is that, through the process of theological thinking, the reconfiguration of Jesus as a subversive bare life offers fresh insight into the agency of Korean comfort women in the sense that their bare lives have so far resisted the unjust world in their search of human rights and dignity. In spite of his tribulations between the Jewish and Roman authorities, Jesus unsettles these sovereign powers in such an ambiguous space. In a similar fashion, Korean comfort women have broadcast the atrocious brutality of Japanese colonial rule in the ambiguous zone beyond the juridical realms—Korean, Japanese, or otherwise—at the national and international levels. The foremost point to remember is that a commemoration of Jesus’ life as the most paradigmatic example of bare life can inspire Korean comfort women to deal with their agony in assuming bare life in the unswerving hope of justice yet to be served through divine intervention in the terrestrial sovereignty in liminal space and time.
Getting Repentance Right: Luther’s Reformation Refocused
Authors: Appold Kenneth G.
Published: August 2018

Luther’s Reformation began with a debate over proper repentance, a fact that tends to get overlooked in most accounts of its history. By focusing on a close reading of the first five of Luther’s “95 Theses,” the following article examines that debate in its context, seeks to understand Luther’s theological insights and places them in conversation with contemporary thoughts and practices of repentance.
Does God Speak Greek?: Pope Benedict XVI’s Euro-Supremacist Supersessionism and the Heterosexuality of Reason
Authors: Grimes Katie
Published: August 2018

Contemporary critics of Christian supersessionism rightly despise its connection to Christianity’s historical persecution of the Jewish people. But theologians and other scholars have not paid enough attention to the political work Christian supersessionism continues to do today. To this end, I examine the work of Pope Benedict XVI, arguing that what I term “Euro-supremacist supersessionism” pervades and helps to shape his theology. Benedict’s supersessionism serves to describe Europe and Christianity as inextricably linked: just as Europe is an essentially Christian continent so is Christianity an essentially European religion. Because it perceives this cultural formation as uniquely universal, Benedict’s supersessionism also advocates a type of European supremacy. But despite its roots in and resonances with German philosophical anti-Judaism, Benedict’s Eurocentric supersessionism does not advance an anti-Jewish politics. His Eurocentric supersessionism instead leads him to take political aim at three initially surprising targets: one, the growing presence of Islam within Europe; two, Europe’s intensifying embrace of lesbian and gay rights; and three, certain strands of liberation theology that originate outside of Europe. Why? I argue that, for Benedict, each of these movements both endangers the marriage he has established between Europe and Christianity—a union he deems necessary to each entity’s survival—and undermines his claim that Christianized Europe possesses a unique universality, which I argue supplies the main source of his implicit belief in its supremacy over all other cultural systems.
Between Religiosity and Spirituality: Christianity and the Reemergence of the Immanentist Spiritualities
Authors: Chinedu Nweke K.
Published: August 2018

The reemergence of immanentist spiritualities, from New Age spirituality to African traditional spiritualities, has been indicative of the twenty-first century. The influx of these spiritualities in the West has ripples of implications to Christianity. At the least, spirituality has been separated from religiosity, with some people identifying themselves as “spiritual but not religious” (SBNR). This work explores the triangular formulae of new spiritualities (the self, nature, divinity) to understand the intricacies of this divergence between religiosity and spirituality, and the implications for Christianity. It argues that theological negligence might not have directly caused the reemergence of many spiritualities, but it warranted the exit of many Christians into the new spiritualities. Through the appraisal of theological anthropology, natural theology, and spiritual theology, it suggests a reprioritization of Christian theology and a constructive relationship with the new spiritualities.
Barium and strontium ferrite-filled composites based on NBR and SBR
Authors: Kruželák Ján , Matvejová Martina , Dosoudil Rastislav , Hudec Ivan
Published: August 2018

In the first part of the research, rubber magnetic composites were prepared by incorporation of strontium and barium ferrite in concentration scale ranging from 0 to 200 phr into rubber matrices based on acrylonitrile–butadiene rubber and styrene–butadiene rubber. The main objective was to investigate the influence of the type and content of magnetic filler on the cross-link density, physical–mechanical and magnetic characteristics of the prepared composites. In the second part of the study, the content of magnetic fillers was kept on constant level—200 phr and the main aim was to investigate the change in mutual combination of both fillers on the cross-linking and properties of the rubber magnets. The results revealed that both fillers show reinforcement effect in the rubber matrices. The higher tensile strength of composites was achieved by application of barium ferrite. Magnetic properties of composite materials were significantly influenced by magnetic characteristics of magnetic fillers. Higher remanent magnetic induction of barium ferrite was reflected in higher remanent magnetization of the equivalent composites. On the other hand, higher coercivity of strontium ferrite resulted in higher coercivity of strontium ferrite-filled composites.
From Trust Convergence to Trust Divergence: Trust Development in Conflictual Interorganizational Relationships
Authors: Brattström Anna , Faems Dries , Mähring Magnus
Published: August 2018

Whereas extant research on trust in interorganizational relationships tends to focus on trust convergence – i.e. members of one focal firm developing similar trust perceptions toward a partner firm – we shift focus to trust divergence – i.e. members of one focal firm developing different trust perceptions toward a partner firm. To explore trust divergence, we conduct an inductive, longitudinal study of one interorganizational relationship characterized by mutual transgressions. We identify shifts in attentional perspectives and referent categorizations as two novel mechanisms for theorizing trust development in interorganizational relationships. In particular, we develop a process model illuminating how these two mechanisms can contribute to trust development patterns in interorganizational relationships that are more discontinuous than existing models would predict. Moreover, we highlight the constructive implications of trust divergence for interorganizational collaboration in the presence of transgression and conflict.
Rethinking growth: Towards the well-being economy
Authors: Lang Mark , Marsden Terry
Published: August 2018

This article considers the impact of growth on economic, social, environmental and cultural sustainability. Although it refutes an extractive model of growth, it suggests that a form of socially and ecologically positive and sustainable growth might have beneficial impacts in certain circumstances and locations. It argues that currently applied models of growth are both inefficient and unsustainable, as they are extractive of finite natural and human resources, and lead to inequalities that produce unaffordable costs. It therefore calls for a more intelligent, efficient, sustainable and place-based approach. Undertaking a general review of Wales, where recent well-being legislation places a sustainable development obligation on all devolved public bodies, it outlines the results of three ‘Deep Place’ case studies that offer an alternative approach to growth within the sustainable place-making context.
Experimental ischemic stroke induces long-term T cell activation in the brain
Authors: Xie Luokun , Li Wenjun , Hersh Jessica , Liu Ran , Yang Shao-Hua
Published: August 2018

Mounting evidence has demonstrated that both innate and adaptive immune cells infiltrate into the brain after ischemic stroke. T cell invasion has been found in the ischemic region up to one month post experimental ischemic stroke and has been shown to persist for years in stroke patients. However, the function and phenotypic characteristics of the brain invading T cells after ischemic stroke have not been investigated. In the current study, we determined the function of brain invading T cells in the acute and chronic phase following experimental ischemic stroke induced by transient middle cerebral artery occlusion. We observed a significant increase of CD4+ and CD8+ T cells presented in the peri-infarct area at up to one month after experimental ischemic stroke. The brain invading T cells after ischemic stroke demonstrated close interaction with active astrocytes and a progressive proinflammatory phenotype as evidenced by the increased expression of T cell activation markers CD44 and CD25, proinflammatory cytokines INF-γ, IL-17, IL-10, TNF-α, and perforin, with corresponding transcriptional factors T-bet and RORc. Our results indicated a prolonged activation of brain invading CD4+ and CD8+ T cells after ischemic stroke which may play a role in the neural repair process after stroke.
Good Character Is What We Look for in a Friend: Character Strengths Are Positively Related to Peer Acceptance and Friendship Quality in Early Adolescents
Authors: Wagner Lisa
Published: August 2018

This study investigates the role of character strengths in peer relationships among early adolescents. A sample of students ( N = 339; [Formula: see text] age = 12.84 years, 53.1% female) nominated friends in the classroom and completed assessments of character strengths, the desirability and importance of character strengths in a friend, and friendship quality. Results indicate that the character strengths of honesty, humor, kindness, and fairness were most desirable and important in a friend. Perspective, love, kindness, social intelligence, teamwork, leadership, and humor were associated with higher peer acceptance. Dyadic analyses of mutual best friends suggested that a number of character strengths were also positively related to friend-rated friendship quality. Overall, the results demonstrate the relevance of character strengths for positive peer relationships in adolescents.
Fifteen-degree clavicular hook plate achieves better clinical outcomes in the treatment of acromioclavicular joint dislocation
Authors: Li Guanghui , Liu Tuoen , Shao Xianfang , Liu Zhijun , Duan Jianhui , Akileh Raji , Cao Shousong , Jin Dadi
Published: August 2018

Objective

Clavicular hook plate application is one of the most commonly used treatment methods for acromioclavicular (AC) joint dislocation, although it may cause multiple postoperative complications. We modified the regularly used 0° hook plate to 15° and compared the clinical outcomes of these two hook plates for treatment of AC joint dislocation.

Methods

Forty-three patients with acute AC joint dislocation were randomly enrolled (0° hook plate, 20 patients; 15° hook plate, 23 patients). The American Shoulder and Elbow Surgeons (ASES) and visual analog scale for pain (VASP) scores were evaluated preoperatively and at 3 days and 1, 2, 3, and 6 months postoperatively and compared between the two groups.

Results

Compared with the preoperative scores, the 6-month postoperative ASES score gradually increased but the VASP score decreased in both groups. Furthermore, the ASES and VASP scores were significantly different between the two groups at every postoperative time point.

Conclusion

The 15° hook plate is superior to the 0° hook plate in reducing shoulder pain and improving postoperative recovery in the treatment of AC joint dislocation.

Level of evidence

Level III; Treatment study (retrospective comparative study).
Increasing evenness in the neighbourhood distribution of income poverty in England 2005–2014: Age differences and the influence of private rented housing
Authors: Fransham Mark
Published: August 2018

A recent change in the geography of poverty in Britain has been reported: it appears to be becoming more evenly distributed in major cities, such that low-income individuals are less likely to be living in the highest poverty areas. Studying all local authority areas in England between 2005 and 2014, this paper finds that this phenomenon is strongly differentiated by age group and local authority type. Poverty amongst children and working age people is becoming more evenly distributed in almost all local authority types, with the largest changes occurring in the most urban areas. The change is strongly associated with the increasing proportion of low-income households living in private sector housing. Conversely, there is evidence of an increasing residential concentration of poverty at older ages. The paper also proposes a method for decomposing a change in rates between changes in the numerator and changes in the denominator. It concludes by discussing the implications of these findings for area effects, area-based initiatives and gentrification by displacement.
Neuronal injuries evidenced by transient cortical magnetic resonance enhancement in hemiplegic migraine: A case report
Authors: Pellerin Arnaud , Marois Clémence , Mezouar Nicolas , Mokhtari Karima , Leclercq Delphine , Law-ye Bruno
Published: August 2018

Background

Magnetic resonance imaging abnormalities in hemiplegic migraine have been described previously but were limited to a cortical thickening and biphasic alternation of hypoperfusion and hyperperfusion. Our report reveals possible blood-brain barrier disruption during migraine.

Case

We present the first demonstrated case of regressive diffuse hemispheric cortical enhancement in sporadic hemiplegic migraine, with histological correlation revealing neuronal lesions similar to ischemic lesions. This is probably due to the severity of the attack as indicated by the left hemiplegia and transient altered consciousness in our 43-year-old male patient.

Conclusion

Cortical contrast enhancement on 3D T1 images may suggest migraine severity and be predictive of neuronal loss.
Should influenza vaccination be mandatory for healthcare workers?
Authors: Lukich Nikolija , Kekewich Michael , Roth Virginia
Published: August 2018

Each year, many healthcare organizations deal with low influenza immunization rates among staff. Mandatory influenza vaccination programs may be considered in order to address this issue. These types of programs have caused controversy in the past, as staff has argued that they infringe upon their liberties and right to autonomy. However, if viewed from a public health perspective, mandatory vaccination programs are beneficial for both employees and patients and can be justified. When individuals make the decision to work in the medical field, it is assumed that their values align with those of the organization for which they work. This overrides their right to autonomy, since they are expected to put the safety of their patients ahead of their own personal interests. Although some may argue that receiving a flu shot is unsafe, evidence has demonstrated the opposite, and the minimal discomfort that may result from a vaccine is not enough to negate the responsibilities that healthcare workers have toward the patients they serve.
Factors Affecting Career Goals of Taiwanese College Athletes From Perspective of Social Cognitive Career Theory
Authors: Chan Chun-Chen
Published: August 2018

The present study attempted to identify the psychological processes associated with the career goals of Taiwanese college athletes. In order to identify the psychological processes potentially associated with career goals, the study drew upon social cognitive career theory (SCCT). The results supported SCCT indicating that career decision-making self-efficacy contributed to vocational interests, outcome expectations, and career goals. Social support was found to be related to career decision-making self-efficacy, and outcome expectations were found to be related to vocational interests. In addition, the results revealed that career decision-making self-efficacy and outcome expectations indirectly affected career goals through vocational interests and that social support indirectly affected career goals through career decision-making self-efficacy. However, the results did not support the hypothesis that social support and outcome expectations contributed to career goals. The practical implications of these findings in terms of the career counseling given to Taiwanese college athletes are discussed.
Work Preferences and General Abilities Among US Pharmacy Technicians and Danish Pharmaconomists
Authors: Desselle Shane P. , Hoh Ryan , Rossing Charlotte , Holmes Erin R. , Gill Amanpreet , Zamora Lemuel
Published: August 2018

Introduction:

The importance of pharmacy support personnel is increasingly recognized. Studies have evaluated workplace issues and evolving roles; however, needed information from technicians themselves is scarce. The purpose of this study was to examine preferences for work activities and the general abilities of US pharmacy technicians and Danish pharmaconomists.

Methods:

Surveys were administered to random samples of US technicians in 8 states and the general population of Danish pharmaconomists. Respondents indicated their preference for involvement in a set of work activities in community or hospital pharmacy on numeric scales. They also self-assessed their level of ability on facets associated with professional practice, in general. Descriptive results were tabulated, and bivariate tests were conducted on total general abilities ratings.

Results:

The 494 technicians and 313 pharmaconomists provided similar ratings on many activities. In community pharmacy, US technician ratings for performance of activities were generally higher than those of pharmaconomists; however, pharmaconomists rated certain “higher order” communication activities quite highly, such as discussing lifestyle changes with the patient. In hospital practice, Danish pharmaconomists provided low preferences for medication handling but high preferences for communication activities. General ability ratings were given high self-evaluations, but lower on some components, such as keeping up with the profession. Employer commitment was a strong correlate for both.

Conclusions:

Evaluation of preferred work activities and general abilities were likely reflected in different scopes of practice between the two and could be insightful for education and work redesign in both countries, particularly the United States, as leaders evaluate shifts in technician professionalization.
Transactive-Goal-Dynamics Theory: A Discipline-Wide Perspective
Authors: Fitzsimons Gráinne M. , Finkel Eli J.
Published: August 2018

Theories of goal pursuit typically conceptualize goal pursuers as isolated actors; in contrast, empirical research from diverse areas of psychology has demonstrated that goal setting, pursuit, and achievement are deeply embedded within social relationships. Because much of this emerging literature is developing within subfields with minimal cross talk, the potential for integration and advances to basic theory has not been realized. The present article leverages transactive-goal-dynamics theory in an effort to bring these literatures together. In doing so, it distills a common set of primary research questions toward the goal of promoting a cumulative, integrative, interdisciplinary field of research on the ways in which goal pursuit is socially embedded.
Cultural Differences in the Meaning of Adolescent Pregnancy
Authors: Dore Martha M. , Dumois Ana O.
Published: August 2018

Based on research performed in a program for pregnant and parenting teenagers, the authors examine the cultural differences in the self-descriptions of black and Hispanic adolescents. Although the family plays an important role in both black and Hispanic cultures, family functioning, role definitions, and expectations for individual members are different. The practice implications of these cultural differences are discussed.
Exploring the Use of Photo-Stories and Fiction Writing to Address HIV Stigma Among Health Professions Students
Authors: Teti Michelle , Schulhoff Anastacia M. , Koegler Erica , Saffran Lise , Bauerband L. A. , Shaffer Victoria
Published: August 2018

HIV/AIDS stigma exists in healthcare and is harmful to people living with HIV (PLWH). Few anti-stigma interventions target undergraduate health professions students, although evidence supports reaching providers early in their training. We developed two different arts-based interventions based on Intergroup Contact Theory: a Photovoice intervention in which they viewed photo-stories of PLWH and a fiction writing intervention in which they developed characters with HIV. We present the results of a qualitative analysis of the post-intervention interviews, to elaborate on what and how students learned from both interventions. Via theme analysis, we identified three similar patterns among both sets of intervention participants. Interventions helped students to understand PLWH as “people first,” experience emotional responses to PLWH, and complicated their understanding of who was living with HIV. All three themes illustrate how Photovoice and fiction writing interrupted stereotypes about PLWH and humanized PLWH to health professions students.
A Correlational Study of Acute Stress and Resilience Among Hospitalized Burn Victims Following the Taiwan Formosa Fun Coast Explosion
Authors: Chen Ya-Lin , Lu Ming-Hsiu , Weng Ling-Tzu , Lin Chin , Huang Ping-Wei , Wang Chih-Hsin , Pan Hsueh-Hsing
Published: August 2018

Although the survival rate of burn patients in the Formosa Fun Coast Explosion disaster increased significantly, for patients facing long-term rehabilitation, there remained great stress. Therefore, the aim of this study was to explore the predictors of resilience among burn patients in this major disaster. We conducted a cross-sectional, descriptive study in a medical center in northern Taiwan, with a total of 30 burn patients enrolled. Patients’ demographics were collected, and the Resilience Scale and Perceived Stress Scale were administered. Multivariate statistical analysis by stepwise and linear regression was used to test these predictors of resilience. The results showed that perceived stress was the key predictor of resilience in the stepwise regression analysis and by adjusting variables including stress level, gender, and education level. These results indicate that the stress level of burn patients should be determined first to provide more targeted methods for reducing stress and improving resilience.
Parent Observations of the Health Status of Infants With Clefts of the Lip: Results From Qualitative Interviews
Authors: Rosenberg Janine , Albert Meredith , Aspinall Cassandra , Bautista Suzel , Crilly Bellucci Claudia , Edwards Todd C. , Heike Carrie L. , Mecham Solange H. , Patrick Donald L. , Stueckle Laura , Kapp-Simon Kathleen
Published: August 2018

Objective:

To explore, using semistructured qualitative interviews, parent observations of their infant’s health as they relate to having a cleft lip or cleft lip and cleft palate (CL±P) and/or associated treatments.

Design:

Cross-sectional, qualitative study across 3 sites.

Setting:

Parents were recruited from 3 academic craniofacial centers. Most interviews were conducted over the telephone, audio-recorded, and transcribed.

Participants:

Forty-one parents (31 English-, 10 Spanish-speaking) were interviewed. Parents had a child ages 1 to 35 months diagnosed with CL±P.

Main Outcome Measure(s):

Twelve domains reflecting infant health and well-being, likely affected by a CL±P and/or associated treatments, were identified from clinical experience and literature review. Study investigators conducted semistructured interviews based on 12 identified domains. After transcripts of the interviews were reviewed, our multidisciplinary team selected illustrative quotes from each domain that reflected consistent observations made by parents.

Results:

Parents’ responses covered all 12 domains. Specifically, parents discussed the domain of feeding most frequently, followed by observations about sleep, development, comfort, breathing, and vocalization.

Conclusions:

We found that parents of infants with clefts provided caregiver-centered language useful in describing their daily observations. No additional domains of infant health were noted by parents. We will use these observations and language to develop and validate a parent-reported observation diary that can augment assessments of the impacts of interventions on infants who are receiving care for CL±P.
Black metal not Black-metal: White privilege in online heavy metal spaces
Authors: Kennedy Tristan
Published: August 2018

With an increasing online presence among Indigenous Australians, it is worth examining the ways in which online communication technology allows the persistence of racism and White privilege in these spaces. I draw on my experience of conducting research in online heavy metal spaces to highlight technological affordances which allow heightened visibility and permanence of racism and White privilege. That is, language in these spaces tends to construct White bodies as superior and positions non-White bodies as other. I conclude that the affordances of heightened visibility and permanence in these online heavy metal spaces present new challenges for approaches to the fight against racism in everyday Australia.
Youth perspectives on parents’ involvement in residential care in Israel
Authors: Sulimani-Aidan Yafit , Paldi Yuval
Published: August 2018

This exploratory study deals with biological parents’ involvement in residential placement in Israel from the point of view of 79 youth who left care. It presents youth’s retrospectives on their parents’ involvement in care and the degree to which the placement staff involved parents in reality. The youth functioning while in care and after leaving were also examined according to their parents’ involvement.

Findings

Results show that only a quarter of the youth reported that staff involved their parents on a regular basis. T-tests and chi square tests showed significant differences in functioning between young adults with high and low parental involvement. Youth whose parents were more involved had better educational achievement in care and after and reported significantly lower involvement in risky behaviors than those with lower parental involvement. However, no group differences were found regarding outcomes in adjustment to military service and financial status.

Applications

The findings emphasize the gaps in parental involvement in care by staff and the potential contribution of engaging biological parents in the lives of their children while in care and toward emancipation.
Juvenile crime drop: What is happening with youth in Spain and why?
Authors: Fernández-Molina Esther , Bartolomé Gutiérrez Raquel
Published: August 2018

One of the most robust findings in criminology is the fall in crime rates throughout the Western world. However, there is still much to be learnt about this and its causes. This case study analyses the Spanish juvenile crime trends and tests the explanatory capacity of the sociodemographic hypotheses. We use aggregate data provided by the police and self-report data. Our analysis could be of interest in a worldwide debate on the crime drop. Demographic changes and the economic situation have little relevance in explaining the changes. However, public policies seem to have had a greater impact on crime trends. Furthermore, gender equality can be considered a possible explanatory factor.
Successful Endovascular Treatment for Aortic Thrombosis Due to Primary Antiphospholipid Syndrome: A Case Report and Literature Review
Authors: Kadoya Yoshito , Zen Kan , Oda Yohei , Matoba Satoaki
Published: August 2018

A 60-year-old man with a history of Raynaud’s phenomenon presented with bilateral intermittent claudication and an ulcer on his right toe. The ankle–brachial index of the right and left legs was 0.77 and 0.75, respectively. Laboratory data showed prolongation of the activated partial thromboplastin time and a positive result on the lupus anticoagulant test. Computed tomography angiography revealed isolated infrarenal aortic stenosis with irregular surface and noncalcified plaques. Intravascular ultrasonography examination demonstrated a noncalcified, irregular, and mobile plaque, suggestive of abdominal aortic thrombosis. In addition to anticoagulant and dual antiplatelet therapy, endovascular treatment was performed. A total of three 40-mm-long balloon-expandable stents were successfully implanted on a 15-mm balloon. The final angiography showed good results except for minimal plaque shifting in the terminal aorta. Three months later, the ulcer resolved and a final diagnosis of primary antiphospholipid syndrome (APS) was made. Clinicians should recognize that APS can affect the abdominal aorta, leading to aortic thrombosis. Endovascular treatment may be the one good treatment option for this rare condition.
Stenosis Caused by Suture-Mediated Vascular Closure Device in an Angiographic Normal Common Femoral Artery: Its Mechanism and Management
Authors: Youn Young Jin , Khalid Salman , Azrin Michael , Lee Juyong
Published: August 2018

Vascular closing devices (VCDs) are widely used to replace manual compression at the femoral puncture site and to reduce the discomfort of patients undergoing percutaneous coronary procedure by shortening bed rest. Among the vascular complications related to these devices, the femoral artery stenosis or occlusion is rarely reported, and its standard management is not well established. We report a case of symptomatic femoral artery stenosis caused by suture-mediated VCD and managed using rotational atherectomy device and balloon angioplasty. In addition, we propose the possible mechanisms for this complication.
Liposomal Curcumin Attenuates the Incidence of Oxidative Stress, Inflammation, and DNA Damage Induced by Copper Sulfate in Rat Liver
Authors: Alhusaini Ahlam , Fadda Laila , Hassan Iman , Ali Hanaa M. , Alsaadan Njood , Aldowsari Nouf , Aldosari Azizah , Alharbi Bshayer
Published: August 2018

Background:

Copper is an essential element that is used widely in agriculture as fungicides and insecticides; for example, it is used to control schistosomiasis and as an antiseptic and germicide. Copper sulfate (CuSO4) induces multiorgan dysfunction through the stimulation of reactive oxygen species and oxidative stress. Despite the numerous pharmacological effects of curcumin (CUR), its pharmacokinetic properties are less promising. Hence, there is an urgent need for novel, effective strategies to attenuate heavy metal toxicity and consequently improve the treatment efficiency. Liposomal curcumin (L-CUR) improves the dissolution, stability, and bioavailability of treatment agents. This study compared the efficacy of CUR and L-CUR with that of desferrioxamine (DES), which is a heavy metal chelator against CuSO4 hepatotoxicity.

Methods:

All treatments with the aforementioned antioxidants were administered for 7 days along with CuSO4. Serum levels of alanine aminotransferase, aspartate transaminase, lactate dehydrogenase, and C-reactive protein, hepatic nitric oxide (NO), and lipid peroxides (malondialdehyde) were measured; protein expression of cyclooxygenase 2 and DNA fragmentation were evaluated. Histopathological examinations were also conducted.

Results:

A toxic dose of CuSO4 induced elevations in the previously measured parameters; these increases were reduced by the tested antioxidants, whereas glutathione (GSH) and superoxide dismutase (SOD) levels were decreased. Treatment with the antioxidants in question modulated these levels. Liposomal CUR has more hepatoprotective efficiency than CUR, and its efficacy was similar to that of DES. The histopathological examinations confirmed these results.

Conclusions:

Liposomal CUR may be useful for the prevention of CuSO4-induced liver injury. Cyclooxygenase 2 protein expression and DNA fragmentation were involved in CuSO4 toxicity and treatment.
Successful endovascular recanalization of a partially occluded basilar artery fenestration
Authors: Meinel Thomas Raphael , Pult Frauke , Gralla Jan , Arnold Marcel , Bassetti Claudio , Jung Simon
Published: August 2018

A 76-year-old man with a history of arterial hypertension, obstructive sleep apnea, dyslipidemia, family history of cardiovascular events, prestroke and overweight presented 90 minutes after acute onset of right-sided sensorimotor hemiparesis, hemiataxia and dysarthria (National Institutes of Health Stroke Scale (NIHSS) 9/42).

Magnetic resonance imaging (MRI) revealed a pontine ischemia and MR angiography showed a thrombus in the middle to distal portion of the basilar artery. Owing to the location, an occlusion of one lumen of a fenestrated basilar artery was suspected. Fearing the risk of peripheral dislocation, intravenous thrombolysis was withheld after an interdisciplinary discussion and direct endovascular thrombectomy (Solitaire stent retriever) was successfully performed by passing the stent retriever specifically through the affected lumen and between the thrombus and the vascular wall, which would normally be avoided. Angiography after complete reperfusion (Thrombolysis in Cerebral Infarction grade 3) confirmed a fenestration in the middle to distal portion of the basilar artery where the thrombus was initially located (blue and green arrow). Follow-up MRI after 24 hours showed only minimal ischemic damage in the left pontine area, and the patient was discharged home with ambulatory physiotherapy for residual minimal gait disturbance (NIHSS 0).
Use of metronomic chemotherapy in the management of a cat with abdominal haemangiosarcoma
Authors: Yee-Ka Cheng Katrina , Krockenberger Mark , Bennett Peter
Published: August 2018

Case summary

A 12-year-old entire domestic shorthair was evaluated for a 5 week history of intermittent vomiting, loss of appetite and weight loss. Abdominal ultrasound revealed a multi-lobulated heterogeneous mass adjacent to the mesenteric vessels. Cytology from fine-needle aspirates was non-diagnostic. Histopathology from a Tru-cut biopsy was consistent with haemangiosarcoma. The cat was treated with metronomic chemotherapy using oral cyclophosphamide. The cat remained clinically well and was euthanased 10 months after diagnosis owing to development of a haemoabdomen.

Relevance and novel information

Prognosis of feline abdominal haemangiosarcoma is generally poor and limited information on treatment is available in the veterinary literature. The use of metronomic chemotherapy with oral cyclophosphamide in this cat provided a 10 month period of good-quality life.
Influence of the Anterolateral Ligament on Knee Laxity: A Biomechanical Cadaveric Study Measuring Knee Kinematics in 6 Degrees of Freedom Using Dynamic Radiostereometric Analysis
Authors: Nielsen Emil Toft , Stentz-Olesen Kasper , de Raedt Sepp , Jørgensen Peter Bo , Sørensen Ole Gade , Kaptein Bart , Andersen Michael Skipper , Stilling Maiken
Published: August 2018

Background:

An anterior cruciate ligament (ACL) rupture often occurs during rotational trauma to the knee and may be associated with damage to extracapsular knee rotation–stabilizing structures such as the anterolateral ligament (ALL).

Purpose:

To investigate ex vivo knee laxity in 6 degrees of freedom with and without ALL reconstruction as a supplement to ACL reconstruction.

Study Design:

Controlled laboratory study.

Methods:

Cadaveric knees (N = 8) were analyzed using dynamic radiostereometry during a controlled pivotlike dynamic movement simulated by motorized knee flexion (0° to 60°) with 4-N·m internal rotation torque. We tested the cadaveric specimens in 5 successive ligament situations: intact, ACL lesion, ACL + ALL lesion, ACL reconstruction, and ACL + ALL reconstruction. Anatomic single-bundle reconstruction methods were used for both the ACL and the ALL, with a bone-tendon quadriceps autograft and gracilis tendon autograft, respectively. Three-dimensional kinematics and articular surface interactions were used to determine knee laxity.

Results:

For the entire knee flexion motion, an ACL + ALL lesion increased the mean knee laxity ( P < .005) for internal rotation (2.54°), anterior translation (1.68 mm), and varus rotation (0.53°). Augmented ALL reconstruction reduced knee laxity for anterior translation ( P = .003) and varus rotation ( P = .047) compared with ACL + ALL–deficient knees. Knees with ACL + ALL lesions had more internal rotation ( P < .001) and anterior translation ( P < .045) at knee flexion angles below 40° and 30°, respectively, compared with healthy knees. Combined ACL + ALL reconstruction did not completely restore native kinematics/laxity at flexion angles below 10° for anterior translation and below 20° for internal rotation ( P < .035). ACL + ALL reconstruction was not found to overconstrain the knee joint.

Conclusion:

Augmented ALL reconstruction with ACL reconstruction in a cadaveric setting reduces internal rotation, varus rotation, and anterior translation knee laxity similar to knee kinematics with intact ligaments, except at knee flexion angles between 0° and 20°.

Clinical Relevance:

Patients with ACL injuries can potentially achieve better results with augmented ALL reconstruction along with ACL reconstruction than with stand-alone ACL reconstruction. Furthermore, dynamic radiostereometry provides the opportunity to examine clinical patients and compare the recontructed knee with the contralateral knee in 6 degrees of freedom.
Feasibility and user experience of virtual reality fashion stores
Authors: Park Minjung , Im Hyunjoo , Kim Do Yuon
Published: August 2018

Virtual reality (VR) is a computer-simulated, realistic three-dimensional environment. VR heightens a user’s sense of being in the environment and enables the user to interact with the environment. We propose that VR can be a very cost-effective way to evaluate fashion retail store designs because of the ease of developing and adjusting the store designs as well as its ability to allow users to closely mimic the real store shopping experience. Also, these benefits create an opportunity for consumer researchers to investigate realistic shopper behaviors. In order to assess the effectiveness of using VR fashion retail store models in developing store designs and in understanding the way shoppers interact with the stores, an experiment with 40 female undergraduate students was conducted. This case study was written to share the advantage of using VR and the challenges VR uniquely presents with both fashion retailers and scholars. Implications for fashion retail store designers and managers as well as consumer researchers are discussed.
Management of Small Bowel Neuroendocrine Tumors
Authors: Scott Aaron T. , Howe James R.
Published: August 2018

Small bowel neuroendocrine tumors (NETs) are increasing in incidence and are now the most common primary malignancies of the small intestine. Despite this increase, the vague presentation and slow growth of these tumors lead to long delays in diagnosis, and many patients present with metastases. Patients with metastatic small bowel NETs have a favorable disease prognosis, particularly when contrasted with other GI malignancies, and benefit from aggressive, multimodal therapy. During the past decade, the options for the diagnosis and treatment of small bowel NETs have increased considerably. This review provides a practical framework for the physician who seek to understand the epidemiology, presentation, diagnosis, and management of small bowel NETs.
Use of Bone-Modifying Agents in Myeloma and Bone Metastases: How Recent Dosing Interval Studies Have Affected Our Practice
Authors: Campagnaro Erica , Reimers Melissa A. , Qin Angel , Alva Ajjai S. , Schneider Bryan J. , Van Poznak Catherine H.
Published: August 2018

The management of bone lesions from advanced solid tumors and multiple myeloma typically includes use of a bone-modifying agent to reduce the risk of skeletal-related events. Recent data demonstrate that when using zoledronic acid to reduce the risk of skeletal-related events in metastatic breast cancer, metastatic prostate cancer, and multiple myeloma, the dosing interval of zoledronic acid may be extended from every 4 weeks to every 12 weeks. The ASCO guidelines on the role of bone-modifying agents in metastatic breast cancer and multiple myeloma address zoledronic acid dosing intervals. Herein, we discuss how new data on dosing of bone-modifying agents influence our clinical practice.
SCML2 promotes heterochromatin organization in late spermatogenesis
Authors: Maezawa So , Hasegawa Kazuteru , Alavattam Kris G. , Funakoshi Mayuka , Sato Taiga , Barski Artem , Namekawa Satoshi H.
Published: August 2018

Spermatogenesis involves the progressive reorganization of heterochromatin. However, the mechanisms that underlie the dynamic remodeling of heterochromatin remain unknown. Here, we identify SCML2, a germline-specific Polycomb protein, as a critical regulator of heterochromatin organization in spermatogenesis. We show that SCML2 accumulates on pericentromeric heterochromatin (PCH) in male germ cells, where it suppresses PRC1-mediated monoubiquitylation of histone H2A at Lysine 119 (H2AK119ub) and promotes deposition of PRC2-mediated H3K27me3 during meiosis. In postmeiotic spermatids, SCML2 is required for heterochromatin organization, and the loss of SCML2 leads to the formation of ectopic patches of facultative heterochromatin. Our data suggest that, in the absence of SCML2, the ectopic expression of somatic lamins drives this process. Furthermore, the centromere protein CENP-V is a specific marker of PCH in postmeiotic spermatids, and SCML2 is required for CENP-V localization on PCH. Given the essential functions of PRC1 and PRC2 for genome-wide gene expression in spermatogenesis, our data suggest that heterochromatin organization and spermatogenesis-specific gene expression are functionally linked. We propose that SCML2 coordinates the organization of heterochromatin and gene expression through the regulation of Polycomb complexes.
Ivy1 is a negative regulator of Gtr-dependent TORC1 activation
Authors: Varlakhanova Natalia V. , Tornabene Bryan A. , Ford Marijn G. J.
Published: August 2018

The highly conserved TORC1 complex controls cell growth in response to nutrients, especially amino acids. The EGO complex activates TORC1 in response to glutamine and leucine. Here, we demonstrate that the I-BAR domain-containing protein Ivy1 colocalizes with Gtr1 and Gtr2, a heterodimer of small GTPases that are part of the EGO complex. Ivy1 is a negative regulator of Gtr-induced TORC1 activation, and is contained within puncta associated with the vacuolar membrane in cells grown in nutrient-rich medium or after brief nitrogen starvation. Addition of glutamine to nitrogen-starved cells leads to dissipation of Ivy1 puncta and redistribution of Ivy1 throughout the vacuolar membrane. Continued stimulation with glutamine results in concentration of Ivy1 within vacuolar membrane invaginations and its spatial separation from the EGO complex components Gtr1 and Gtr2. Disruption of vacuolar membrane invagination is associated with persistent mislocalization of Ivy1 across the vacuolar membrane and inhibition of TORC1 activity. Together, our findings illustrate a novel negative-feedback pathway that is exerted by Ivy1 on Gtr-dependent TORC1 signaling and provide insight into a potential molecular mechanism underlying TORC1 activation by vacuolar membrane remodeling.
The unusual flagellar-targeting mechanism and functions of the trypanosome ortholog of the ciliary GTPase Arl13b
Authors: Zhang Yiliu , Huang Yameng , Srivathsan Amrita , Lim Teck Kwang , Lin Qingsong , He Cynthia Y.
Published: August 2018

The small GTPase Arl13b is one of the most conserved and ancient ciliary proteins. In human and animals, Arl13b is primarily associated with the ciliary membrane, where it acts as a guanine-nucleotide-exchange factor (GEF) for Arl3 and is implicated in a variety of ciliary and cellular functions. We have identified and characterized Trypanosoma brucei (Tb)Arl13, the sole Arl13b homolog in this evolutionarily divergent, protozoan parasite. TbArl13 has conserved flagellar functions and exhibits catalytic activity towards two different TbArl3 homologs. However, TbArl13 is distinctly associated with the axoneme through a dimerization/docking (D/D) domain. Replacing the D/D domain with a sequence encoding a flagellar membrane protein created a viable alternative to the wild-type TbArl13 in our RNA interference (RNAi)-based rescue assay. Therefore, flagellar enrichment is crucial for TbArl13, but mechanisms to achieve this could be flexible. Our findings thus extend the understanding of the roles of Arl13b and Arl13b–Arl3 pathway in a divergent flagellate of medical importance.

This article has an associated First Person interview with the first author of the paper.
Ταβέρνες, καφενεία και ο συμβολισμός τους στο έργο του Νίκου Χατζήκυριάκου-Γκίκα
Authors: Προβίδη Ιωάννα
Published: August 2018

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