bluuebunny/crossref_metadata_2025 huggingface dataset:
Predicting Psychological Well-Being Based on Psychological Capital Components and Stress Coping Strategies: A Case Study of Hormozgan Province Gas Company
Authors: ASKARI Azadeh , BAZGIR Bahman , KARIMIFARD Zahra , GHOLIPOUR Maryam , ESLAMI Bahareh , SADEGHI Najme
Published: August 2022

Introduction: The increasing importance of having capable employees in organizations to achieve the goals emphasizes the need to pay more attention to the psychological well-being of employees and the factors affecting it. This study aims to investigate the role of components of psychological capital and stress coping strategies in predicting the psychological well-being of employees of Hormozgan Gas Company.
Methods: This applied correlational study was conducted cross-sectionally and by cluster sampling method in 1400 on 130 personnel of Hormozgan Gas Company. In order to collect data, Lutans Psychological Capital Questionnaire (PCQ), Coping Inventory for Stressful Situations (CISS-21), and Reef Psychological Well-Being scale (RSPWB) were used. Then, the data were analyzed using SPSS-24 software and stepwise regression test.
Results: The results of this study showed that there is a positive correlation between psychological well-being and psychological capital and problem-based coping strategies and a negative correlation between psychological well-being and emotion-centered coping strategy. The variables of hope, resilience, and emotion-based coping strategy have an effective predictive role on the psychological well-being index.
Conclusion: High resilience and hope and the use of problem-oriented coping styles predict higher psychological well-being of employees. Therefore, it is suggested that managers consider more educational programs to improve psychological capital, educate appropriate coping styles, and use more problem-solving strategies for employees, and strengthen resilience and hope in them.
Evaluating the Relationship between HSE Management and Job Satisfaction and Performance Quality among the Production Center (Employees of Hacoupian Clothing Industrial ‎Company: A Case Study)
Authors: AKBARI Hamid , SARBANDI Fahimeh
Published: August 2022

Introduction: The productivity of an organization is closely related to the improvement of the safety and health of employees and the development of knowledge and skills of human resources in advancing the organization goals. Based on a combination of questionnaire and survey, this study examines the impact of implementing safety management practices on the performance and job satisfaction of employees in Iran's production units.
Research Method: This descriptive-cross-sectional study was conducted in 1400 on 200 employees and managers of the Hacoupian clothing industrial company located in Tehran province. 130 of them were selected based on random sampling using the Morgan table. Data collection tools included a researcher-made questionnaire, which was further confirmed by experts by applying their opinions regarding its validity and reliability. It was approved by experts. The analysis method in this study is mainly descriptive and the type of research is relational. Data and research hypotheses were respectively tested using Structural equation modeling (SEM) and Partial least squares (PLS) approach through SPSS26 software.
Results: Findings showed the appropriate fit of measurement and structural models. In addition, results demonstrated the positive effect of improving safety on the job satisfaction of employees in production units, as well as the negative effects of not paying attention to the health of the working environment on the quality of employees' performance.
Conclusion: The more companies and governments pay attention to the issue of operational health and safety, the organizational and environmental situation will be formed in such a way that it will optimally motivate employees and increase the quality of production and operations in the organization.
An Iranian Patient with Fructose 1,6 Bisphosphatase Deficiency: A Case Report
Authors: Mirhosseini Naser Ali , Mirhosseini Shima , Saeida-Ardekani Maryam
Published: August 2022

Background: Deficiency of hepatic fructose 1,6 bisphosphatase (FBPase), a key enzyme in gluconeogenesis, impairs the formation of glucose from all gluconeogenic precursors including dietary fructose. Patients present with life threatening metabolic acidosis, fasting hypoglycemia, hepatomegaly, hyperketosis, elevated lactate and uric acid level. Glycerol and glycerol-3 phosphate have been found in the urine. The diagnosis of FBPase deficiency is confirmed via DNA molecular analysis from peripheral leukocytes. The acute life threatening episodes are treated with IV glucose at high rate and bicarbonate to control hypoglycemia and acidosis.
Case Report: Here we report a girl referred with anorexia, lethargy, recurrent vomiting, progressive respiratory distress, and hepatomegaly following respiratory viral infection. She also had a history of twice similar attacks but milder than previous episodes. The test results showed hypoglycemia and severe metabolic acidosis. Despite proper treatment, the patient died of pulmonary edema following a respiratory viral infection.
Conclusion: Once FBPase deficiency has been diagnosed and adequate management introduced, its course is usually benign. Growth both psychomotor and intellectual development are unimpaired and tolerance to fasting improves with age.
Impactos da pandemia da Covid-19 na saúde mental do professor: uma revisão integrativa de literatura
Authors: Caldas Calila Mireia Pereira , Silva Joilson Pereira da , Santos Karine David Andrade
Published: August 2022

O contexto pandêmico da Covid-19 trouxe consequências sociais, como o fechamento das escolas, que podem impactar a saúde mental dos professores. Nessa perspectiva, este estudo objetivou apresentar evidências científicas sobre os fatores de adoecimento associados à atividade laborativa e psicológica provocados pela Covid-19 sobre os professores do ensino fundamental, médio e superior. Após realizada uma revisão integrativa da literatura, com buscas nas bases de dados científicas da Medline/PubMED, ERIC, EBSCO, Scopus, SciELO e LILACS publicados entre janeiro de 2020 a fevereiro de 2021, dezesseis artigos foram incluídos neste estudo. O principal impacto explorado nos artigos é sobre o que a pandemia ocasionou nos professores, como: quadros de medo e pânico, estresse e transtorno de estresse pós-traumático, síndrome de burnout, ansiedade e transtorno de ansiedade generalizado, distúrbio do sono, angústia, exaustão, depressão, transtorno bipolar e distanciamento emocional. As condições de trabalho em home office e as especificidades da pandemia apresentaram desafios aos professores e algumas estratégias de enfrentamento foram utilizadas como o apoio social, individual com métodos de relaxamento e institucional. São necessárias novas propostas institucionais e governamentais que apresentem benefícios em termos de saúde mental e promovam o enfrentamento ao adoecimento em professores.
Principais considerações: Engajamento dos jovens na américa latina e no caribe na resposta à COVID-19
Authors: Bishop Stephanie , Corrêa Juliana
Published: August 2022

A pandemia de COVID-19 teve impacto profundo nos jovens na América Latina e no Caribe (ALC). Desde 2020, os jovens da ALC enfrentam muitos desafios, como adaptação aos ambientes virtuais de aprendizagem, perdas e depressão, o desemprego e muito mais, sem sinais claros de alívio. Embora as medidas sociais e de saúde pública instituídas pelos governos sejam necessárias para retardar a transmissão da COVID-19, em grande parte não consideraram as necessidades da população jovem. Com poucos apoios, os jovens tiveram que enfrentar a pandemia sozinhos. À medida que a resposta à pandemia evolui, surgem questões-chave para profissionais e governos, tais como: Que lições podem ser aprendidas a partir das perspectivas dos jovens sobre a resposta à COVID-19 até agora? E como podemos envolver melhor os jovens como parte da preparação e resposta à pandemia agora e no futuro? Este resumo baseia-se na literatura cientifica e cinzenta que explora como a COVID-19 afeta os jovens, bem como na literatura que descreve a resposta à pandemia na ALC e em outras regiões, e apresenta considerações sobre como envolver os jovens, vendo-os não apenas como uma parte da população afetada, mas também como parceiros na resposta. Destina-se ainda a orientar os atores humanitários, profissionais de saúde pública, defensores da juventude, profissionais de envolvimento da comunidade e outros envolvidos na resposta à COVID-19. Por fim, o resumo também contribui para a base de evidências existente sobre o impacto da COVID-19 nos jovens. Essas lições são úteis para fortalecer a preparação e as respostas programáticas aos surtos. Os jovens são classificados como indivíduos com idades entre os 10 e 24 anos. Principais considerações são compartilhadas para adolescentes (10-19 anos) e jovens (15-24 anos). Barbados e Brasil foram escolhidos como estudos de caso devido ao seu grande número de jovens (compreendendo pouco menos de 20% da população em ambos os países), bem como suas diferentes respostas nacionais à COVID-19, apesar de enfrentarem desafios semelhantes durante a pandemia. Este resumo faz parte da série da Social Science in Humanitarian Action Platform (SSHAP) sobre considerações de ciências sociais relacionadas à COVID-19. Faz parte de uma série de autoria de participantes da SSHAP Fellowship, Coorte 2, e foi escrita por Stephanie Bishop e Juliana Corrêa. As contribuições foram fornecidas por especialistas no assunto da UNICEF, do Ministério da Juventude de Barbados e da Universidade do Espírito Santo. O resumo teve o apoio da equipe do SSHAP no Institute of Development Studies e editado por Victoria Haldane (Anthrologica). Este resumo é responsabilidade da SSHAP.
Interaction of Ideology and Institutions in Treating Violent Men
Authors: Jansson Peter M. , Saxonberg Steven
Published: August 2022

Since Sweden has a reputation for having a pragmatic, technocratic

approach to solving social problems, the question arises as to why the

country uses different methods at the national and the local level for

treating violent men. If studies show that one method is superior to

others, we would expect both levels of government to use similar

treatment methods. Despite the emphasis on pragmatic solutions,

ideology plays an important role, as the Swedish government in recent

decades has largely accepted the New Public Management approach to

governance. However, because of differences in institutional

arrangements, it becomes logically appropriate for the national level to

utilize a different type of therapy (Cognitive Behavioral Therapy) than

the local level (Psycho Dynamic Therapy among others). Thus, a

combination of an ideological shift to New Public Management and

institutional differences can explain the differences in therapeutic

approaches, rather than reliance on scientific studies.
Desventuras dos professores na formação para o capital
Authors: Simão Andréia Aparecida
Published: August 2022

Está é uma resenha sobre o livro intitulado Desventuras dos professores na formação para o capital.
Escolas novas para Porto Alegre: Leonel Brizola na prefeitura da capital do Estado do Rio Grande do Sul (1956-1958)
Authors: Quadros Claudemir de
Published: August 2022

Por meio deste texto, busca-se apresentar o relatório intitulado Escolas novas para Pôrto Alegre, publicado pela Prefeitura Municipal de Porto Alegre, pelo qual pode-se conhecer as diretrizes de atuação do executivo municipal em relação à educação, no decorrer do governo de Leonel Brizola (1956-1958). Trata-se, portanto, de um estudo documental, direcionado a tornar acessível um documento importante para a História da Educação do Rio Grande do Sul.
Fault Detection of Landing Gear Retraction/Extension Hydrau-lic System Based on Bond Graph-linear Fractional Transfor-mation Technique and Interval Analytic Redundancy Relations
Authors: Cao Yuyuan , Duan Shixuan , Li Yanjun , Li Xudong , Zhao Zejian , Wang Xingye
Published: August 2022

Various factors, such as uncertainty of component parameters and uncertainty of sensor meas-urement values, contribute to the difficulty of fault detection in the landing gear retrac-tion/extension hydraulic system. In this paper, we introduce linear fractional transformation technology and uncertainty analysis theory for the construction of the diagnostic bond graph of the landing gear retraction/extension hydraulic system. In this way, interval analytical redundancy relations and fault signature matrix can be derived. Using the fault signature matrix, existing faults of the system can be preliminarily detected and isolated. Additionally, interval analytical re-dundancy relations can be used to detect system faults in detail, and cases analysis can be carried out to determine if the actuator is externally or internally leaky, and if the landing gear selector valve is reversing stuck. Compared to the traditional analytical redundancy relations, this method takes into account the negative factors of uncertainty; and compared to the traditional absolute diagnostic threshold, the interval diagnostic threshold is more accurate and sensitive.
Human Resource Management and Selected Personnel Indicators in Sustainable Development
Authors: Sukalova Viera , Stofkova Zuzana , Stofkova Jana
Published: August 2022

The article deals with human resource management and selected personnel indicators in sus-tainable development. The main goal of this paper is to analyse and describe human resource management focused on audit of workload, motivation of employees, the competence of staff, their knowledge and experience. The article shows how the selected personnel indicators are examined in selected establishments of multinational company in Slovakia, as an attractive em-ployer interested in growth of its employees, thus employer branding. For research methods, a case study methodology is used. Data collection was carried out through a questionnaire survey with employees in the company as well as an interview with sale advisors and managers. The research aimed to point out a case study of the investigation of selected personnel indicators in human resources management in a selected company and to examine the perception of the per-formance of employees in connection with their financial evaluation and their satisfaction in the selected company with an impact on employees´ performance. Furthermore, the research aimed to determine whether there was a dependence between the subjectively perceived performance of the employees and selected aspects. Further indicators were calculated, such as employment rate, proportion of wasted time and labour productivity.
MSSI-based Dispersion-managed Link Configured by Randomly-distributed RDPS Only in Former Half Section
Authors: Chung Jae-Pil , Lee Seong-Real
Published: August 2022

The weakness of the dispersion-managed link combined with optical phase conjugation to compensate for optical signal distortion caused by chromatic dispersion and nonlinear Kerr effect of standard single mode fiber is its limited structural flexibility. We propose dispersion map that can simultaneously compensate for the distorted wavelength division multiplexed signal while increasing the configurational flexibility. Each residual dispersion per span (RDPS) in the former half of the proposed link is randomly determined, and in the latter half, the arrangement order of RDPS is the same as or inverted in the former half. We confirm that the dispersion maps in which the RDPS distribution pattern in the latter half is opposite to the arrangement order in the former half are more effective in compensation, and rather, the compensation effect is better than in the dispersion map of the conventional scheme. The notable result of this paper is that the increase of flexibility can be achieved through random arrangement of RDPS in the former half, and the compensation improvement can be achieved by through inverse arrangement in the latter half which make the distribution profile of each half link roughly symmetric with respect to the midway optical phase conjugator.
Liquid Smoke Treatment for Natural Fibers: The Effect on Tensile Properties, Surface Morphology, Crystalline Properties, and Functional Groups of Banana Stem Fibers
Authors: Muslimin Mukhlis , Rahim Mustamin , Seng Ahmad , Rais Sandi
Published: August 2022

This study aims to investigate the effect of banana stem fibers (BSFs) treatment with liquid smoke on changes in the micro-mechanics properties of BSFs, the tensile strength of single fibers, mor-phology, crystalline properties, and functional groups. The research used four model specimen variations, namely fiber without treatment and immersion in liquid smoke for 1, 2, and 3 hours. The BSFs with treatment was dried in an oven with a temperature of 40ºC for 30 minutes. Several tests were conducted, including a tensile test of single fiber capacity of 50N standard ASTM 3379-02, SEM observation, XRD, and FTIR test. The results showed that the highest increase in fiber strength was P2J, which was 264.21 MPa, and the lowest was TP fiber at 148.54 MPa. Fibers treatment with liquid smoke can form strong C-C elemental bonds caused by the H2O degradation process in BSFs, hence carbon atoms (C) are dense, and in conditions of excessive H2O degradation, the fiber strength will become brittle and the liquid smoke can increase the tensile strength of the fiber. The morphology of the fiber changed where the untreated fiber was covered with lignin, while the treated fiber had an elongated rectangular line pattern, porous, and the lignin was eroded. Crystalline properties in the X-ray diffractogram pattern differ between untreated and treated fibers. At an angle of 2ϴ, the lowest diffraction peak is around 160 in untreated wool, and the highest is 230 in treated fiber. The functional group of the fiber has changed where there is a difference in the wave crest between untreated and treatment fiber. The longer immersion time, the element of Carbon (C) will increase. In conclusion, treating BSFs with liquid smoke can change the physical, mechanical, and chemical properties, hence becoming a choice of composite reinforcement material in the future which is lightweight and environmentally friendly.
Cancer Care Access in Chile’s Vulnerable Populations During the COVID-19 Pandemic
Authors: Cuadrado Cristóbal , Vidal Francisca , Pacheco Jorge , Flores-Alvarado Sandra
Published: August 2022

Objectives. To examine the COVID-19 pandemic’s impact on cancer care access in Chile, analyzing differential effects by insurance type, gender, and age.

Methods. We conducted a quasi-experimental study using interrupted time series analysis. We used multiple data sources for a broad evaluation of cancer-related health care utilization from January 2017 to December 2020. We fit negative binomial models by population groups for a range of services and diagnoses.

Results. A sharp drop in oncology health care utilization in March was followed by a slow, incomplete recovery over 2020. Cumulative cancer-related services, diagnostic confirmations, and sick leaves were reduced by one third in 2020; the decrease was more pronounced among women and the publicly insured. Early diagnosis was missed in 5132 persons with 4 common cancers.

Conclusions. The pandemic stressed the Chilean health system, decreasing access to essential services, with a profound impact on cancer care. Oncology service reductions preceded large-scale lockdowns and supply-side disruptions. Importantly, not all population groups were equally affected, with patterns suggesting that gender and socioeconomic inequalities were exacerbated. (Am J Public Health. 2022;112(S6):S591–S601. https://doi.org/10.2105/AJPH.2021.306587 )
Pseudoaneurysm of the Peroneal Artery After Ankle Arthrodesis Treated by Endovascular Coil Embolization
Authors: Kasai Taro , Higashida Tomohiko , Hayashi Takaki , Yasui Tetsuro
Published: August 2022

Case:

Pseudoaneurysms of the peroneal artery around the ankle joint have rarely been reported. We present the case of a 64-year-old man with a pseudoaneurysm of the anterior perforating branch of the peroneal artery associated with a screw inserted from the anterolateral distal tibia during ankle arthrodesis. Endovascular treatment with selective catheterization and coil embolization was successfully performed. The ankle joint achieved bone union without delay, and the pseudoaneurysm did not recur at the 18-month follow-up.

Conclusion:

This is the first report describing a pseudoaneurysm of the peroneal artery after ankle arthrodesis. Successful outcomes can be achieved by endovascular treatment.
Pediatric Septic Arthritis of the Knee due to Fusobacterium necrophorum in a Patient with Down Syndrome
Authors: Trutner Zoe , Hwang Richard , Bowen Richard
Published: August 2022

Case:

A 16-year-old boy with a history of Down syndrome presented with right knee pain and swelling. He was diagnosed with isolated septic arthritis of the knee due to Fusobacterium necrophorum in the absence of current or recent oropharyngeal infection. He was successfully treated with arthroscopic irrigation and debridement and 12 weeks of oral antibiotics.

Conclusion:

Fusobacterium necrophorum is a part of the normal oral flora and a rare cause of septic arthritis, typically associated with recent oropharyngeal infection. However, patients with immune dysregulation such as those with Down syndrome may develop isolated septic arthritis due to transient hematogenous seeding.
Kovid-19’un Borsaya Etkisi: Gelişmekte Olan Piyasalardan Kanıtlar
Authors: DURAN Mahmut Sami , KONYA Sevilay
Published: August 2022

Salgın, siyasi olaylar, deprem gibi olağanüstü durumların borsa getirileri üzerinde etkisi olduğu bilinmektedir. Bu çalışma, yükselen piyasa ekonomilerinde Kovid-19 salgınının borsa getirileri üzerindeki etkisini açıklamayı amaçlamaktadır. Bu nedenle çalışmamızda hem Kovid-19 vakalarının hem de Kovid-19’a bağlı ölümlerin etkisini ölçmek amacıyla iki ayrı model kurulmuştur. Çalışmamızda Arellano, Froot ve Rogers Tesadüfi Etkiler Tahmincisi ve Arellano–Bond GMM Tahmincisi uygulanmıştır. Çalışmanın sonucunda Arellano, Froot ve Rogers Tesadüfi Etkiler Tahmincisi sonuçlarına göre Kovid- 19 vakalarının borsa piyasası üzerinde pozitif ve anlamlı bir etkisi olduğu belirlenmiştir. Ancak Arellano–Bond GMM Tahmincisi sonuçlarına göre kovid-19 vakalarının borsa piyasası üzerinde anlamlı bir etkisi bulunamamıştır. Kovid-19 ölümlerinin borsa endeksi üzerindeki etkisi ise hem Arellano, Froot ve Rogers Tesadüfi Etkiler Tahmincisi hem de Arellano Bond tahmincisine göre pozitif ve istatiksel olarak anlamlı belirlenmiştir.
Factors Affecting the Fear of Covid-19
Authors: YILMAZ Fikriye , BASKICI Çiğdem
Published: August 2022

The aim of the study is to determine the factors affecting individuals' fear of COVID-19. The sample of the study consisted of 1,582 individuals aged between 18 and 65 years living in Turkey. Data are collected through an online questionnaire. To analyze data, descriptive statistics, validity-reliability analysis, and hypothesis tests are performed. Results of the study show that participants have a very high level of fear of COVID-19. The backward multiple regression model is developed to determine the independent variables that affect the fear of COVID-19. It is determined that there is a statistically significant higher level of fear of COVID-19 in females, in those who use social media as a source of information, those who have a fear of losing their loved ones, those without a good economic situation, those with a change in health system confidence after the COVID-19 pandemic, those with moderate health status and those with chronic diseases. Consequently, it is recommended that multidisciplinary teams that include mental health professionals should be created to prevent the spread of outbreaks and their negative effects, and healthcare professionals should consider the fear of COVID-19 as a part of the management of chronic diseases.
Visualizing heterogeneous dipole fields by terahertz light coupling in individual nano-junctions used in transmon qubits
Authors: Wang Jigang , Kim Richard , Park J-M , Haeuser Samuel , Huang C , Cheng D , Koschny T , Oh Jin-Su , Zhou L , Kramer M , Luo L , Kopas Cameron , Cansizoglu H , Mutus J , Yadavalli K
Published: August 2022

The fundamental challenge underlying superconducting quantum computing is to characterize heterogeneity and disorder that lead to local electric field concentration, charge scattering, dissipation and ultimately decoherence. It is particularly challenging to probe deep sub-wavelength electric field distribution under electromagnetic wave coupling at individual nano-junctions and correlate them with structural imperfections from interface and boundary, ubiquitous in Josephson junctions used in transmon qubits. A major obstacle lies in the fact that conventional microscopy tools are incapable of measuring {\em simultaneous} at nanometer and terahertz, ``nano-THz” scales, which often associate with frequency-dependent charge scattering in nano-junctions. Here we directly visualize interface nano-dipole near-field distribution of individual Al/AlO$_{x}$/Al junctions used in transmon qubits. Our THz nanoscope images show a remarkable asymmetry across the junction in electromagnetic wave-junction coupling response that manifests as ``hot" vs ``cold" cusp spatial electrical field structures and correlates with defected boundaries from the multi-angle deposition processes in JJ fabrication inside qubit devices. The asymmetric nano-dipole electric field contrast also correlates with distinguishing, ``overshoot" frequency dependence that characterizes the charge scattering and dissipation at nanoscale, hidden in responses from topographic, structural imaging and spatially-averaged techniques. The scheme can be extended to guide qubit nano-fabrication for ultimately optimizing qubit coherence times.
Influence of waste brake oil on the rheological properties of coal sludge slurry
Authors: Xu Enle , Miao Zhenyong , Jiang Xiaofeng
Published: August 2022

In this work, the effect of waste brake oil (WBO) on the dispersion property of coal oil-sludge slurry (COSS) was investigated and comprehensively analyzed. Apparent viscosity of COSS decreases from 997mPa.s to 276mPa.s with the increasing of SS content from zero to 12% under the CV of 17.70 MJ/kg and O/S of 2.0. The combination of sewage sludge (SS) and WBO could decrease the apparent viscosity of COSS, and SS content and O/S are two important parameters to affect the apparent viscosity. WBO mainly contains the hydrocarbon compound and a lot of oxygenated functional groups according to its GC/MS results. WBO could cover on the surface of SS and coal particle, and reduce their hydrophobic character and the adsorbance amount of dispersant based on the FTIR, XPS and adsorption performance results. In addition, the mechanism of WBO on slurry characteristics of COSS was investigated. With the low content of WBO, the liquid bridges from WBO force the solid particles to adhere together and form a stable network structure, thus reducing the flow ability of the suspension. With the increasing of WBO, the network structures could be broken into cells by stirring it, resulting in a dramatic decrease in viscosity. This research provides a potential way to dispose the SS and waste industry oil.
Zinc Levels Assay in Children with Autism Spectrum Disorder by Quantum Magnetic Resonance Analyzer and Direct Colorimetry
Authors: Zayed Khalid Mahmoud El Sayed , Ibrahim Mostafa Azzaz , Farid Maisa Nasr , Shourbagy Omar El- Sayed Omar El- , Tarkan Reham Sabrey
Published: August 2022

Background: Autism is a long-term disability and a developmental disorder in which many studies suggested an association with serum low levels of zinc. In addition, the zinc to copper (Zn/Cu) ratio can be a biomarker of ASD as it is abnormally low in individuals with autism.Aim: The present study aimed to determine the levels of Zn in the bodies of children with autism spectrum disorder (ASD). The assay is done using new technology, the quantum magnetic resonance analysis (QMRA) method, and comparing its results with a reference testing laboratory method to determine the validity, sensitivity, and specificity of the new measurement method.Method: The study was performed in a group of children (M=19; F=11; age range=3-15 years) with ASD (n=30) and a control group of typically developing children (n=30) matched in terms of sex and age. The main variables in this study were the body values of Zn measured with a QMRA-998 8th Generation device and in patients’ sera by the reference direct colorimetric method.Statistical Analysis: Results were compared across groups using descriptive statistics, Pearson and Spearman’s correlation coefficients, Chi-Square significance, analysis of variance (ANOVA), and linear regression. In addition, a sensitivity and specificity cross-tabulation test was performed to evaluate the QMRA method in measuring Zn levels.Results: Both methods showed lower means for Zn levels in the ASD group than in the control group with a significant correlation between the two methods when measuring Zn levels. With the QMRA method, the sensitivity was 84% and specificity was 87%.Conclusion: It is suggested to test blood levels of Zn in all autistic children and give them a Zn supplement if needed. Non-invasive health measurement devices such as QMRA can be used as a screening or adjunct tool for the measurement of Zn levels in humans.
Health Related Quality Of Life (HRQOL) Among Patients With Childhood Acute Lymphoblastic Leukemia In Saudi Arabia: Cross- Sectional Study.
Authors: alqub aljohara , binsalleh raghad , alnaim lamya , alsultan abdulrahman , awwad sameh
Published: August 2022

BackgroundIncidences of Acute lymphoblastic leukemia (ALL) is the highest type among hematological malignancy affecting children. Cancer patients experience bothersome symptoms during chemotherapy courses, either from cancer itself or side effects from chemotherapy, which would be visible or invisible. In health care, where therapies aim to prolong survival, maintaining or improving HRQOL is becoming increasingly important.Methods This was a cross-sectional study. A total of 100 patients aged 2-12 years from King Saud University Medical City (KSUMC) and King Fahad Medical City (KFMC) are included to complete the parent proxy report of Pediatric Quality Of Life Inventory TM (PedsQLTM) 3.0 Cancer Module (Arabic version) which is a module to measure HRQOL in pediatrics.ResultsA total number of 100 patients participated in this study, their ages ranging from 2-12 years with a mean of 6. Male represented 59% of the sample and the other 41% were female. The overall HRQOL is divided into three levels, High (16%), intermediate (38%), poor (46%) represent the majority of the patients. The lowest scores of sub-scales that have affected HRQOL shown as mean were procedural anxiety (41.47), treatment anxiety (58.33) and worry (62.75) were the maximum mean value is 100. Procedural anxiety is affected by age, patients aged 6 or less have more procedural anxiety than older age. Patients who receive treatment for a year or less show an increase in worry. Male show more cognitive problems than females.Conclusions Results show that the majority of patients have poor HRQOL with a significant association between male gender and cognitive problems, younger age and procedural anxiety, short duration of treatment and worry.
Extension of Tablo TrEatmeNt Duration (XTEND) Study: Succesful 24 hour prolonged therapy with Tablo in critical patients
Authors: Zaman Tahir , Moore Kasadi , Jellerson Jennifer , Chahal Yaadveer , Schumacher Joshua , Silva Cynthia , Aragon Michael
Published: August 2022

BACKGROUND: The Tablo® Hemodialysis System (Tablo) is an all in one, easy-to-learn device featuring integrated water purification, on demand dialysate production and two-way wireless data transmission and is approved for use in the acute, chronic, and home settings. Prior reports have demonstrated Tablo’s ability to achieve clinical goals, seamlessly integrate into hospitals and reduce cost across a wide range of treatment times. Extension of the Tablo cartridge to 24 hours allows prolonged therapy and even greater flexibility for prescribers in the acute setting. The objective is to report on the first ever experience with Tablo prolonged therapy between 12 and 24 hours in critically ill patients treated at a single-center ICU. METHODS:Nursing staff were trained during a single training session on Tablo prolonged therapy. After a run-in period of five treatments, Tablo data were collected via real-time transmission to a cloud-based, HIPAA compliant platform and reviewed by site staff. Dialysis treatment delivery, clinically significant alarms, and clotting events were recorded. Sub-group analysis between COVID-19 positive and negative patients were reported. RESULTS:One hundred (100) consecutive Tablo prolonged treatments had a median prescribed treatment time of 24 hours and a median achieved treatment time of 21.3 hours. Median cartridge usage was 1.3 per treatment. The dialysis treatment time was delivered in 91% of treatments, with 6% ending early due to an alarm, and 3% ending due to clotting. Clinically significant alarms occurred at a median rate of 0.5 per treatment hour with a resolution time of 18 seconds. Median blood pump stoppage time related to these alarms was 2.3 minutes per treatment. Blood pump stoppage time was higher in the COVID-19 subgroup when compared to the non-COVID-19 subgroup. CONCLUSION:Tablo successfully achieves prescribed treatment time with minimal therapy interruptions from alarms or cartridge changes. This data demonstrates the effectiveness of Tablo in achieving personalization of treatments necessary for unstable patients and enabling successful delivery of extended therapy with minimal clotting. Tablo’s prolonged therapy meets the needs of critically patients, including COVID-19 positive patients, requiring renal replacement therapy for greater than 12 hours.
Meta Selective C–H Borylation Directed by Secondary Silicon Oxygen Interaction
Authors: Chattopadhyay Buddhadeb , Guria Saikat , Has Mirja Md , Dey Sayan
Published: August 2022

Remote meta selective C–H functionalization , , of aromatic compounds remains a challenging problem in chemical synthesis. Here, we report an iridium catalyst bearing a bidentate pyridine-pyridone (PY-PYRI) ligand framework that efficiently catalyzes this meta selective borylation reaction. We demonstrate that the developed concept can be employed to introduce a boron functionality at the remote meta position of phenols, phenol containing bioactive and drug molecules, which was an extraordinary challenge. Moreover, we have demonstrated that the method can also be applied for the remote C6 borylation of indole derivatives including tryptophan that was the key synthetic precursor for the total synthesis of Verruculogen and Fumitremorgin A alkaloids. The origin of the remote meta selectivity was described as a secondary silicon oxygen interaction that was never used in C–H functionalization chemistry.
TMEM201 overexpression is associated with tumor progression and unfavorable prognosis in hepatocellular carcinoma
Authors: Wang Xiaolei , Fang Jun , Wang An , Zhu Wuhui
Published: August 2022

Background More and more evidences suggest there was a relationship between nuclear envelope and tumor development, but the functional contributions of TMEM201 remain largely unidentified. Objective This study aimed to explore the TMEM201 mRNA expression and its potential biologic functions in hepatocellular carcinoma (HCC) patients. Methods Expression array and clinical data were collected from the Cancer Genome Atlas (TCGA) database. TMEM201 expression data and its clinical information in HCC were confirmed by Chi-square test and Student’s t test. We used Kaplan–Meier analysis, Cox regression and nomogram to evaluate the prognostic capability of TMEM201. Gene set enrichment analysis (GSEA) was applied to find significant biological pathways associated with TMEM201. Results In contrast to normal tissues, TMEM201 was remarkably upregulated in HCC (P < 0.05). High-expressing TMEM201 was significantly related to advanced TNM stage, poor histologic grade, high Ishak score, worse Child–Pugh grade, vascular invasion, positive alpha fetoprotein (AFP) (P < 0.05). Kaplan–Meier analysis revealed that high TMEM201 expression was associated with poor overall survival (OS) and disease-free interval (DFI). In addition, multivariate analysis confirmed that high-expressing TMEM201 was an independent predicter of unfavorable OS and DFI (P < 0.05). On the basis of TMEM201 and TNM stage, the nomograms had a good predictive performance. Furthermore, TMEM201 DNA copy gain and miR-500a-3p upregulation were related to high TMEM201 mRNA expression in TCGA-LIHC. GSEA analysis demonstrated that “cell cycle” pathway, “DNA replication” pathway, “spliceosome” pathway and “homologous recombination” pathway were significantly enriched. Conclusion Above mentioned results indicate that TMEM201 has potential as a novel therapeutic target in HCC, and it is a good predictor associated with progression and prognostics of HCC.
Maximum Tumor Absorbed Dose Measured by Voxel-Based Multicompartmental Dosimetry as a Response Predictor in Yttrium-90 Radiation Segmentectomy for Hepatocellular Carcioma
Authors: Rincón Javier Orcajo , Regi Amanda Rotger , Peña Ana Matilla , Berenguer Laura Reguera , Leyte Manuel González , Martín Laura Carrión , Santa Jaime Atance García De La , Boyra Miguel Echenagusia , Ruiz Cristina González , Rodriguez Arturo Colón , Farto Juan Carlos Alonso
Published: August 2022

Objective
Advances in hepatic radioembolization are based on a selective approach with radical intent and the use of multi-compartment dosimetric analysis. The objective of this study is to assess the utility of voxel-based dosimetry in the quantification of actual absorbed doses in radiation segmentectomy procedures and to establish cut-off values predictive of response.
Methods
Ambispective study in hepatocarcinoma patients treated with radiation segmentectomy. Calculated dosimetric parameters were mean tumor absorbed dose, maximum tumor AD, tumor AD in 30, 50 and 70% of tumor volume and mean AD in non-tumor liver. Actual absorbed dose (aAD) was calculated on the Y-90-PET/CT image using 3D voxel-based dosimetry software. To assess radiological response, localized mRECIST criteria were used. Objective response rate (ORR) was defined as CR or PR.
Results
24 HCC patients, BCLC 0 (5), A (17) and B (2) were included. Mean yttrium-90 administered activity was 1.38GBq in a mean angiosome volume of 206.9cc and tumor volume 56.01cc. Mean theoretical AD was 306.3Gy and aAD 352Gy. A very low concordance was observed between both parameters (rho_c 0.027). ORR at 3 and 6m was 84.21% and 92.31% respectively. Statistically significant relationship was observed between maximum tumor absorbed dose and complete radiological response at 3m (p 0.022).
Conclusion
A segmental approach with radical intention leads to response rates greater than 90%, being the tumor maximum absorbed dose the dosimetric parameter that best predicts radiological response in voxel-based dosimetry.
Development and implementation of new online strategies that increase physical activity behavior in cancer patients
Authors: Barrio Soraya Casla , Herrero Lucía Gil , Montealegre Monica Castellanos , Santamaría Marina Pollan , Torre Julio De la
Published: August 2022

Purpose
The purpose of this study was to evaluate effectiveness of different online exercise strategies to increase physical activity levels in cancer patients implemented during the lockdown that may be maintained as usual care after it.
Methods
Three different strategies were designed and implemented during the lockdown, adapting the exercise oncology service in two ways: based on restrictions of the pandemic situation and the evolution of pandemic information.
Results
After exercises interventions, cancer patients reported a significant rise of 92% in physical activity levels and a reduction of 52.9% in sitting time. In terms on the weight, there were no significant changes.
Conclusions
Online programs were an effective strategy to increase physical activity levels in cancer patients during the lockdown, particularly when the partial lockdown was in effect. A higher level of control and longer intervention were more effective in increasing physical activity levels in cancer patients during and after the lockdown.
TINYCD: A (Not So) Deep Learning Model For Change Detection
Authors: Codegoni Andrea , Lombardi Gabriele , Ferrari Alessandro
Published: August 2022

The aim of change detection (CD) is to detect changes occurred in the same area by comparing two images of that place taken at different times. The challenging part of the CD is to keep track of the changes the user wants to highlight, such as new buildings, and to ignore changes due to external factors such as environmental, lighting condition, fog or seasonal changes. Recent developments in the field of deep learning enabled researchers to achieve outstanding performance in this area. In particular, different mechanisms of space-time attention allowed to exploit the spatial features that are extracted from the models and to correlate them also in a temporal way by exploiting both the available images. The downside is that the models have become increasingly complex and large, often unfeasible for edge applications. These are limitations when the models must be applied to the industrial field or in applications requiring real-time performances. In this work we propose a novel model, called TinyCD, demonstrating to be both lightweight and effective, able to achieve performances comparable or even superior to the current state of the art with 13-150X fewer parameters. In our approach we have exploited the importance of low-level features to compare images. We introduce a novel mixing block capable of cross correlating features in both space and time domains. Finally, to fully exploit the information contained in the computed features, we define the PW-MLP block able to perform a pixel wise classification.
Advanced Directives’ Knowledge in Palliative Care: Do the Sociodemographic Features Influence it? A Survey in a Portuguese Population.
Authors: Martins Catarina Sampaio , Nunes Rui
Published: August 2022

BackgroundAdvance care planning (ACP) allows the definition of goals and preferences for future health care, improving communication between patients and caregivers. Portuguese Advance Directives (PAD) ensure a living will and/or the assignment of a health care proxy (HCP). Knowledge on PAD and HCP is low, and the influence of demographic factors is still not clear. We intend to identify sociodemographic features associated with knowledge on PAD and HCP, and the registration of PAD.MethodsPatients in palliative care and their caregivers were included, and sociodemographic data was acquired. Participants were asked about their previous knowledge of PAD, the role of an HCP, and about previously writing a PAD.ResultsA total of 60 patients and their caregivers were included, with differences regarding age (p < .001), gender (p = .003), education (p < .001), job (p < .001), marital status (p = .043), and access to the internet (p = .003), but not regarding religion (p = .21). 13.3% were aware of PAD, 15.0% were aware of HCP, and 5.0% previously filled a PAD. Non-Catholic participants were significantly more aware of these three topics.ConclusionsOur results are partially different from other Portuguese reports, probably due to differences in the populations, but consistent with results from other countries. Reports on the influence of religion in ACP are conflicting, with similarities in religious values between patients and HCP influencing end-of-life decisions. Improving education is necessary, namely in palliative care. There is low awareness of PAD and HCP in palliative care, and there is higher knowledge on these topics among non-Catholic individuals.Trial registration: ClinicalTrials.gov ID NCT05090072. Retrospectively registered on 22/10/2021.https://clinicaltrials.gov/ct2/show/NCT05090072?term=NCT05090072&cond=Advance+Directives&draw=2&rank=1
A Recombinant Capripoxvirus Expressing the F Protein of Peste des Petits Ruminants Virus and the P12A3C of Foot-and-mouth Disease Virus
Authors: Li Jidong , Wang Jianlin , Guo Yanan , Gong Zhenxing , Cai Xuepeng
Published: August 2022

Background: Peste des petits ruminants (PPR), foot-and-mouth disease (FMD) and goat pox (GP) are three important infectious diseases that infect goats, sheep and other small ruminants. It is well-known that the prevention of three diseases rely mainly on their individual vaccines. However, the vaccines have a variety of different disadvantages, such as short duration of immunity, increasing the number of vaccinations, and poor thermal stability. The purpose of this study is to construct a recombinant goat pox virus (rGPV) capable of expressing the F gene of PPRV and the P12A3C gene of FMDV as a live vector vaccine.Results: The IRES, FMDV P12A3C and PPRV F genes into the multi-cloning site of the universal transfer plasmid pTKfpgigp to construct a recombinant transfer plasmid pTKfpgigpFiP12A3C, and transfected GPV-infected lamb testis (LT) cells with liposomes and produced by homologous recombination Recombinant GPV (rGPV/PPRVF-FMDVP12A3C, rGPV). The rGPV was screened and purified by green florescence protein (GFP) and xanthine-guanine-phosphoribosyltransferase gene (gpt) of Escherichia coli as selective markers, and the expression of rGPV in LT cells was detected by RT-PCR and immunofluorescence techniques. The results showed that the virus strain rGPV/PPRVF-FMDVP12A3C containing FMDV P12A3C and PPRV F genes was obtained. The exogenous genes FMDV P12A3C and PPRV F contained in rGPV were normally transcribed and translated in LT cells, and the expression products could specifically react with PPRV and FMDV antiserum. Then, the rGPV was intradermally inoculated with goats, the animal experiments showed that rGPV/PPRVF-FMDVP12A3C could induce high levels of specific antibodies against GPV, PPRV and FMDV. Conclusions: The constructed rGPV induced high levels of specific antibodies against GPV, PPRV and FMDV. The study provides a reference for " one vaccine with multiple uses " of GPV live vector vaccine.