bluuebunny/crossref_metadata_2025 huggingface dataset:
APOL1 Kidney Risk Variants and Proteomics
Authors: Chen Teresa K. , Surapaneni Aditya L. , Arking Dan E. , Ballantyne Christie M. , Boerwinkle Eric , Chen Jingsha , Coresh Josef , Köttgen Anna , Susztak Katalin , Tin Adrienne , Yu Bing , Grams Morgan E.
Published: May 2022

Background and objectives

The APOL1 risk variants (G1 and G2) are associated with kidney disease among Black adults, but the clinical presentation is heterogeneous. In mouse models and cell systems, increased gene expression of G1 and G2 confers cytotoxicity. How APOL1 risk variants relate to the circulating proteome warrants further investigation.

Design, setting, participants, & measurements

Among 461 African American Study of Kidney Disease and Hypertension (AASK) participants (mean age: 54 years; 41% women; mean GFR: 46 ml/min per 1.73 m2), we evaluated associations of APOL1 risk variants with 6790 serum proteins (measured via SOMAscan) using linear regression models. Covariates included age, sex, percentage of European ancestry, and protein principal components 1–5. Associated proteins were then evaluated as mediators of APOL1-associated risk for kidney failure. Findings were replicated among 875 Atherosclerosis Risk in Communities (ARIC) study Black participants (mean age: 75 years; 66% women; mean eGFR: 67 ml/min per 1.73 m2).

Results

In the AASK study, having two (versus zero or one) APOL1 risk alleles was associated with lower serum levels of APOL1 (P=3.11E-13; P=3.12E-06 [two aptamers]), APOL2 (P=1.45E-10), CLSTN2 (P=2.66E-06), MMP-2 (P=2.96E-06), SPOCK2 (P=2.57E-05), and TIMP-2 (P=2.98E-05) proteins. In the ARIC study, APOL1 risk alleles were associated with APOL1 (P=1.28E-11); MMP-2 (P=0.004) and TIMP-2 (P=0.007) were associated only in an additive model, and APOL2 was not available. APOL1 high-risk status was associated with a 1.6-fold greater risk of kidney failure in the AASK study; none of the identified proteins mediated this association. APOL1 protein levels were not associated with kidney failure in either cohort.

Conclusions

APOL1 risk variants were strongly associated with lower circulating levels of APOL1 and other proteins, but none mediated the APOL1-associated risk for kidney failure. APOL1 protein level was also not associated with kidney failure.
I, Jill Alexander, American Girl Revolutionary
Authors: Haghanikar Taraneh M
Published: May 2022

Analyzing the insider-outsider continuum in Remembrance of the Sun (1986, 2011) by Kate Gilmore, the purpose of this paper is to reveal different levels of being a female outsider protagonist moving along the insider-outsider continuum, maintaining an outsider voice, and at the same time developing an insider perspective. Remembrance of the Sun is a historical fiction authored by an outsider and set in 1978, one year before the Islamic revolution in Iran. After moving from New England to Tehran, Jill, a seventeen-year-old American girl, struggles to adjust to an unfamiliar lifestyle. However, her experience becomes a story of love and fascination when she meets Shaheen, the charismatic Iranian boy who is the first French horn player in the high school band. Frequently, Jill as an outsider to Persian culture is aligning herself with Shaheen’s culture and their romance acts as a bridge, between two seemingly disparate cultures. Remembrance of the Sun reinforces that insider-outsider status is not fixed but situated within a continuum in a state of flux. The innocence of Jill and Shaheen’s romance moves “Jill Alexander, American girl revolutionary” (p. 170) toward the insider position. At the end, Jill, crosses American-Iranian cultural gap with her own pace.
Animals as subjects of dignity in the Brazilian Law
Authors: Marafon Renata , Junior Roberto Miyashiro , Vasconcelos Priscila E. A.
Published: May 2022

It is easy to see how animals have been treated over the years by humans, like property, without rationality, objects. Most recently studies have showed that is not true, on contrary, the simpler way, they are able to have some sensibility, or, sensitive animals, and the last years, the law are bringing these concepts to their rules, including giving decisions in animals favor. Other countries’ Constitutions, Brazilian own rules and decisions, are going along this news, and this will be the main purpose of this study, using the deductive method and bibliographical research, how the history of dignity has been changing over the years, considering animals as subjects; and about specific objectives, a few studies of dignity; how animals are saw by the law and finally, how come justice are changing its way to see them
Implementation of Principal’s Entrepreneurship Competency in Building Competitive Advantage (Case Study at SMKM 7 Malang, East Java, Indonesia)
Authors: Halima Nur , Suprapti Sri
Published: May 2022

This study aims to analyze and describe the entrepreneurial competence of principals in building a competitive advantage at SMKM 7 Gondanglegi, Malang Regency. This research approach uses a qualitative approach with the type of research being a multi-site study. Data collection techniques using in-depth interviews, participant observation, and documentation. The steps of data analysis consist of data collection, data reduction, data presentation, and drawing conclusions. The technique of checking the validity of the data is done through credibility, dependability, confirmability, and data transferability. The results of this study found the following new findings: the entrepreneurial competence of school principals in building competitive advantage in schools requires optimizing internal production loving and sustainable innovation, this can be done with the following notes: 1) Principals must be able to work hard in an effort to achieve school success as effective learning organization. 2) The principal must have a strong motivation to achieve success in carrying out his main duties and functions. 3) The principal never gives up and always looks for solutions in dealing with obstacles at school. 4) The principal must have an entrepreneurial instinct in managing school production/service activities as a source of student learning.
Orientalism in Laila Halaby’s Once in a Promised Land
Authors: Naem Ali Dakhil , Ghadban Alaa Abbas
Published: May 2022

In this paper, the researcher show how Laila Halabypresents informative perception into the conflicts confrontation Arab Americans in post 9/11 America. Halaby turns the Western look upon the Arab societies. Laila Halaby symbolizes an America which is conspiratorial and submerged with religious enthusiasms. After 9/11, Halaby’s American characters become increasingly fanaticism and mistrustful of Arabs and Islamic cultures. Halaby, then, portrays intolerant and xenophobic American characters overwrought with doubts and discloses a post 9/11 America that is widespread with anti-Arab racism. Halaby also propounds that the widespread American perception of a world patently divided between East and West only arouses global crises such as drought, poverty and war. She also declares that the juveniles that occurred on September 11, 2001, were a direct result of these epidemics. Moreover, Halaby offers a perspective of Americans as ignorantly perceiving the United States as alienated from crises impending all nations. For this reason, Halaby's novel functions as a cautionary story decreeing Americans to transcend a binary frame of reference for avoiding further crises from escalating within or beyond American borders.
Editorial
Authors: Olivera Córdova María Elena , Kozak Rovero Gisela
Published: May 2022

El análisis de la literatura y la cultura lesbiana requiere de una visión compleja, la conjugación de miradas amplias y de las parciales, de la historia de las sociedades, de las mujeres y de su actividad escritural, por regiones, por autoras y por obras, y, en muchos casos, además de la consideración de género y de sexualidad, también de las identidades trasnacionales y fronterizas, y de las narrativas nacionalistas o de exclusión en América Latina. Asimismo, para seguir los pasos de la conformación de estas narrativas, se necesita buscar sus vínculos con los feminismos, las implicaciones de clase, las segregaciones raciales, los movimientos contra la homofobia considerando la literatura un proceso inmerso en múltiples procesos de las sociedades en el transcurso del tiempo, un constante diálogo entre lo particular y lo general, entre el pasado, el presente y las expectativas, para evitar nuevas esencializaciones o miradas que tiendan a la parcialización.
La primera ficción lesbiana en el Perú: una aproximación a Confesiones de Dorish Dam
Authors: Salazar Jiménez Claudia
Published: May 2022

En 1929, se publica la primera novela de temática lésbica en el Perú: se trata de las Confesiones de Dorish Dam de Delia Colmenares. A partir del concepto ficciones lesbianas, acuñada por la crítica argentina Laura Arnés, este ensayo analiza la novela de Colmenares a partir de las disrupciones críticas que su discurso presenta en tres aspectos: El primero es la crítica al modelo y las expectativas sociales impuestas sobre las mujeres peruanas a inicios del siglo XX. El segundo es su carácter subversivo frente a las representaciones tradicionales de la sexualidad al visibilizar el deseo lésbico y construir la búsqueda de un oído lésbico. Por último, analizaré las discusiones que entabla esta novela con los discursos hegemónicos del Perú y cómo responde, asume y disputa la construcción del ideario de lo nacional, abriendo una incisión entre las estéticas y políticas del modernismo y del costumbrismo y haciendo una crítica a su propia clase social.
Cuerpos que saben decir yo
Authors: Cuesta Mabel
Published: May 2022

Las mujeres lesbianas hemos sufrido, a nivel global, de largas exclusiones dentro de los movimientos feministas y lgbtiq; dominando en el primero las figuras de mujeres burguesas heterosexuales y en el segundo, los hombres gays. En el contexto cubano con todo y la tan proclamada revolución socialista de 1959, dichas exclusiones han encontrado también espacio y han sometido a las identidades disidentes a procesos de silencio y persecución. En la presente pieza me interesa destacar los sedimentos productivos del trauma que las lesbianas hemos sufrido y también las posibilidades de futuro que se nos presentan hoy a través de la herramienta de autorrepresentación que es el video clip musical. Propongo entonces una escritura/lectura híbrida e interrumpida tanto por testimonios en primera persona de dos lesbianas cubanas de diferentes generaciones (sus historias como botón de muestra) como por el análisis vía close reading de dichos clips. Sugiero con todo ello que el acceder a plataformas digitales diseñadas para la interacción y representación sociocultural podría llegar a convertirse en signo de cambio para nuestros destinos en la isla.
Controversia sobre la racionalidad en el comportamiento del consumidor
Authors: Gallegos-Daniel Cecilia , Taddei Bringas Isabel Cristina
Published: May 2022

La racionalidad es un concepto que ha sido estudiado desde hace mucho tiempo y bajo varias disciplinas y enfoques. El interés por su análisis surge de su importancia como una de las funciones mentales o capacidades humanas que más influyen en la conducta al estar ligada a la toma de decisiones. El consumir es una de las conductas más consuetudinarias del ser humano, constantemente se consume y, por lo tanto, se toman decisiones de compra. Este proceso constituye, al mismo tiempo, una base fundamental para el funcionamiento de los mercados. El artículo aborda la racionalidad, inicialmente, desde el enfoque de la economía convencional o teoría económica neoclásica que concibe individuos como tomadores de decisiones racionales, y, posteriormente, incorpora el enfoque de la economía del comportamiento (EC), que incluye en la ecuación otros elementos como la emoción, la motivación, la actitud y la percepción, factores que se supondrían irrelevantes pero que esta disciplina busca integrar al estudio de una racionalidad limitada. Se considera relevante esta reflexión al advertirse que en la toma de decisiones de compra del consumidor inciden factores que se agregan a su racionalidad e incluso podrían distorsionarla.
Fronteras entre ciencia y política en los espacios deliberativos
Authors: Zapata Clavería Miguel Alberto
Published: May 2022

En este trabajo se analizarán tres propuestas deliberativas para la gestión de controversias sobre ciencia y tecnología: el comité asesor del gobierno holandés tal como es descrito por Bijker, las encuestas ciudadanas impulsadas por Fishkin y los foros híbridos de Callon. La primera nos dará la oportunidad de evaluar las ventajas y desventajas de un formato basado en el diálogo entre expertos que atiende a inquietudes sociales pero que queda clausurado al público. La segunda mostrará el impacto que puede tener la inclusión de ciudadanos sin conocimiento experto en un espacio deliberativo. La noción de foro híbrido, por último, nos permitirá someter a crítica el trabajo de frontera y la atribución de identidades del que dependen el comité asesor y las encuestas deliberativas. El análisis comparativo de estas propuestas visibilizará algunos de los problemas que debe atender la teoría deliberativa cuando se traslada al ámbito de las controversias públicas sobre ciencia y mostrará que la separación entre hechos/valores, ciencia/política y expertos/legos constituye una estrategia que no mejora la calidad epistémica de las decisiones ni aumenta necesariamente la confianza pública en la ciencia.
La precariedad salarial en la industria automotriz en México. Brechas pendientes ante la nueva gobernanza laboral del T-MEC
Authors: García Humberto , Carrillo Jorge , Bensusán Graciela
Published: May 2022

Ante la posibilidad de que una empresa automotriz instalada en México pueda ser acusada de dumping social si no respeta las reglas del T-MEC y las normas internas en materia de libertad sindical y negociación, que exigen la representatividad de los sindicatos y el apoyo de los trabajadores a la contratación colectiva, podría esperarse que las negociaciones futuras establezcan criterios explícitos encaminados a la recuperación salarial. En este contexto es importante considerar en qué monto deben elevarse los salarios para dejar de ser precarios en la industria automotriz. Dada la heterogeneidad salarial existente entre las diferentes empresas, derivada de las características regionales y diferentes niveles tecnológicos y segmentos de producto, este artículo se pregunta qué tan generalizada o específica debe ser la determinación salarial en las futuras negociaciones sindicales. Para dar una respuesta, este artículo compara los salarios dignos calculados para empresas localizadas en diferentes regiones, con distinto país de origen, antigüedad, segmento de mercado y volumen de producción. A partir de este ejercicio, se identifican las brechas salariales que pueden servir de referencia en las negociaciones bajo la nueva normativa laboral del T-MEC. El artículo realiza una adaptación ad hoc de la metodología de salario digno de Anker y Anker (2017) en plantas de Aguascalientes (Nissan i y ii), Hermosillo (Ford), Puebla (vw), San Luis Potosí (General Motors) y Toluca (Chrysler-Fiat), calculados para 2017 y 2019.
Perspectivas de ciudadanía como repertorios para la participación: hacia un enfoque complementario
Authors: Navarro Rivera Isidro
Published: May 2022

El objetivo de este ensayo es contribuir a la comprensión del concepto de ciudadanía, mostrando que en realidad conviven diferentes perspectivas que complementan el repertorio de recursos que utilizan los ciudadanos en situaciones para fines específicos. En un primer apartado se hace un recorrido de la construcción de la noción moderna de ciudadanía y las perspectivas que la nutren. En un segundo apartado se argumenta la convivencia de estas diferentes ópticas, para ello recuperamos experiencias de comunidades indígenas de Oaxaca y de la elección de autoridades municipales por sistema normativo propio en el municipio de Ayutla de los Libres, Guerrero, México, en 2018
Vertical Axis Wind Turbine with Inverter
Authors: Sayyed Saklen Shamshu , Hargude Siddhesh Tatyaba , Bhopale Abhishek Arun
Published: May 2022

Abstract: On the expanding cost of non-inexhaustible assets, sustainable assets are increasingly sought after.In this system, we make utilization of Vertical Axis Wind Turbine for creating energy, for the inverter.A Vertical Axis Wind Turbine is a kind of wind turbine where the principle rotor shaft is set transverse to the breeze while the fundamental parts are situated at the base of the turbine. it comprises of a vertical axis windmill, DC motor, 12V battery, DC inverter and transformer. VAWTS do not need to be pointed into the wind, which removes the need for wind sensing and orientation mechanisms. Keywords: VAWT, Wind Turbine, Vertical axis, Inverter
Peningkatan Kesadaran Hukum tentang Konsep dan Problematika Pelaksanaan Hukum Gadai
Authors: Ayu Isdiyana Kusuma
Published: May 2022

Masyarakat yang menjaminkan barangnya dalam gadai gelap banyak mengalami kerugian. Dari praktik gadai gelap itulah yang dapat menimbulkan bunga dalam kegiatan gadai yang tidak sesuai, sehingga dalam hal ini bermasalah. Penyuluhan hukum gadai ini dilaksanakan dengan penggalian informasi, pengindetifikasian permasalahan yang sering terjadi di dalam masyarakat sehingga dapat memberikan arahan penyelesaian hukum secara tepat, tahap penyuluhan hukum terkait konsep gadai untuk memberitahukan informasi hukum kepada masyarakat dan segala problematika hukumnya agara secara praktis dapat dipahami hukum dan penyelesaiannya oleh masyarakat, dan tahap evaluasi dari penyuluhan hukum agar dapat mengetahui tingkat pemahaman masyarakat dari interaksi tanya-jawab. Berdasarkan hasil evaluasi kegiatan maka didapatkan hasil bahwa terjadi peningkatan keilmuwan dan pemahaman peserta penyuluhan hukum gadai dalam hal: 1) Pengetahuan problematika yang seringkali muncul dalam pegadaian; 2) Aspek hukum gadai; 3) hak dan kewajiban para pihak dalam gadai; dan 4) pengetahuan hak debitur ketika terjadi pelunasan hutang dengan jaminan gadai.
Improving Legal Awareness About The Concept and Problematics Of Implementing Pawn Law. People who pledge their goods under illegal pawning suffer a lot of losses. It is this illegal pawning practice that can lead to interest in unsuitable pawning activities, so that in this case there is a problem. Pawning legal counseling is carried out by extracting information, identifying problems that often occur in society so that it can provide direction for legal settlement appropriately, legal counseling stages related to the concept of pawning to notify legal information to the public and all legal problems so that the law can be practically understood and its resolution by the community, and the evaluation stage of legal education in order to know the level of community understanding of the question-and-answer interaction. Based on the results of the evaluation of activities, it was found that there was an increase in the knowledge and understanding of the participants of the pawning law counseling in terms of: 1) Knowledge of problems that often arise in pawnshops; 2) legal aspects of pawning; 3) rights and obligations of the parties in the pledge; and 4) knowledge of the debtor's rights when there is repayment of the debt with a pledge guarantee.
Organoleptic and physico-chemical evaluation of capretto baladi goats: a value-added meat alternative in an extensive rearing system.
Authors:   Faculty of Agricultural Sciences, Holy Spirit University of Kaslik, Kaslik, Lebanon, Abi Saab S. , Esseily F. ,   Faculty of Public Health-II, Lebanese University, Fanar, Lebanon, Saliba M. ,   Faculty of Agricultural Sciences, Holy Spirit University of Kaslik, Kaslik, Lebanon, Aad P.Y. ,   Department of Sciences, Faculty of Natural and Applied Sciences, Notre Dame UniversityLouaizeh, Zouk Mosbeh, Lebanon
Published: May 2022

The local Baladi breed is considered a common source of fresh meat in Lebanon. Due to the extensive rearing system and the scarcity of pasture, kids resulting from multiple births are not reared, though cultural preference for young meat may valorize these twin kids as an expensive delicacy. Few studies observed growth parameters, physical-chemical and sensory properties of meat in Baladi kids. Therefore, 24 male Baladi kids were fed milk ad libitum post-natally for 24 days, after which 9 were randomly selected and fed pasture grass ad libitum and goat milk (Control), and 15 were fed only milk (Capretto) twice per day. Animals were slaughtered at 4, 6 and 8 weeks of age and body organs compared. Feed intake was measured by weighing kids pre- and post- feeding, and body weight measured twice per week. Meat chemical properties were total ether-extracted fat, kjeldhal protein, and minerals. Meat organoleptic properties were evaluated by consumers for color, taste, odor, richness, juiciness, tenderness and overall appreciation, as cooked by housewives or professionals. Data were analyzed as a CRD using SPSS 10.0 and presented as LSMeans ± SEM. Results showed that Capretto consumed increasing levels of milk from 4 to 8 weeks, with ADG decreasing (P<0.05) from 4 to 8 weeks. Capretto showed 5% less (P<0.05) weight than control kids. Carcass yield was higher (P< 0.05) for Capretto (44.5 ± 3.4 %) than control (36.3 ± 3.3%), with Capretto showing smaller viscera and lower hemoglobin. Both blood and meat (protein, cholesterol) composition did not differ (P>0.05) between Capretto and control, although capretto showed lower (p<0.05) meat fat content than control kids. Meat organoleptic characteristics were desirable at weeks 4 and 6 for both Capretto and control kids, whereas only Capretto meat stayed desirable at week 8. To conclude, Capretto kids have similar properties to their traditional counterparts, with added desirable properties for a longer growing period, in addition to the increased health benefit of lower fat content.
Histological alterations in Kidney and Liver of laboratory mice following intramuscular injection of Montevipera bornmuelleri (Werner, 1898) Venom.
Authors:   Biology Departement, USEK, Kaslik-Jounieh, Lebanon, kossaif Eliane , Hraoui-Bloquet Souad ,   Département of Biology, Faculty of Sciences, Section II, Lebanese University, (Fanar), B.P. 90656 Jdeidet El Maten, Lebanon, Sadek Ryiad ,   Departement of Biology, American University of Beirut Lebanon, Fajloun Ziad ,   Department of Biology, Faculty of Sciences, Section III, Lebanese University, El Kobeh, Lebanon, Accary Claudine ,   Department of Biology, Faculty of Sciences, Section III, Lebanese University, El Kobeh, Lebanon, Hleihel Walid ,   Faculty of Medical Sciences, USEK, Kaslik-Jounieh, Lebanon
Published: May 2022

Histopathological changes after bites of the Montivipera bornmuelleri viper, endemic to high altitudes areas of Lebanon, have not yet been investigated. Our study focuses on histological changes and irreversible damages in the kidney and liver of white laboratory Balb/c mice that received an intramuscular injection of lyophilized venom diluted in saline solution (NaCl 0.9%). Different venom concentration doses ranging from 0.25 mg/kg to 15mg/kg in a total injection volume of 100µl was injected intramuscularly (IM) into 5 groups of mice. After dissection, observations showed no macroscopically identifiable damages in any of the organs studied. However, tissue samples from the liver and the kidney were obtained for histological studies at various time intervals following the venom injection. The histological study was carried out using the Bouin solution (fixing bath), followed by dehydration in alcohol. Paraffin-embedded sections were stained using hemalun-easine. Tissues from 6 control mice, which received only an injection of saline solution, were also examined. The common histological alterations observed microscopically in the liver and the kidney were: pycnotic nuclei, necrosis, vacuolization, cytoplasmic destruction, edema, hemorrhage and congestion of blood vessels. Moreover, inflammatory infiltration of lymphocytic cells was observed in the prevascular regions of both organs. The histological changes observed appeared within 1h and intensified with time. These changes were proportional to the dose of the venom injected into the laboratory mice. Our results on what happens in the kidney and liver of mice after injecting the venom of M. bornmuelleri had many similarities with the effect of venom of other vipers (e. g. Daboia palestinea, Bitis ssp, Bothrops moujenis etc…) observed by others authors.
Modelling rainfall in Karkheh dam reservoir of Iran using time series analysis (stochastic ARIMA models).
Authors:   Department of Water Sciences and Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran, PO Box 1477893855, Hamidi Machekposhti Karim , Sedghi Hossein ,   Department of Water Sciences and Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran, PO Box 1477893855, Telvari Abdolrasoul ,   Department of Civil Engineering, Islamic Azad University, Ahvaz, Iran, PO Box 3733361349, Iran, Babazadeh Hossein ,   Department of Water Sciences and Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran, PO Box 1477893855
Published: May 2022

Time series analysis and prediction has become a major tool in different applications in meteorological and hydrological phenomena, such as rainfall, temperature, evaporation, flood, drought etc. Among the most effective approaches for analyzing time series data is the auto regressive integrated moving average (ARIMA) model introduced by Box and Jenkins. In this study we used Box-Jenkins methodology to build non-seasonal ARIMA model for annual rainfall data of Karkheh dam reservoir in Iran for Jelogir Majin and Pole Zal stations (upstream of Karkheh dam reservoir) for the period 1966-2015. In this paper, ARIMA 8.1.1 and 9.1.1 models were found adequate for annual rainfall at Jelogir Majin and Pole Zal stations, respectively, and these models were used to predict the annual rainfall for the coming ten years to help decision makers to establish priorities in terms of water demand management. The statistical analysis system (SAS) and statistical package for the social science (SPSS) softwares were used to determine the best model to use for these series.
Etude du polymorphisme sanguin dans la population de Honaïne: analyse comparative à l’échelle Méditerranéenne.
Authors:   Laboratoire de valorisation de l’action de l’homme pour la protection de l’environnement et application en santé publique (équipe environnement et santé), Faculté des Sciences, Université Abou Bekr Belkaïd de Tlemcen, Algérie., Bouazza Hayet , Aouar Metri Ammaria ,   Laboratoire de valorisation de l’action de l’homme pour la protection de l’environnement et application en santé publique (équipe environnement et santé), Faculté des Sciences, Université Abou Bekr Belkaïd de Tlemcen, Algérie.; Laboratoire d’Anthropologie des Religions et comparaison, Faculté des Sciences Humaines et Sociales, Université Abou Bekr Belkaïd de Tlemcen, Algérie., Moussouni Abdellatif ,   Laboratoire d’Anthropologie des Religions et comparaison, Faculté des Sciences Humaines et Sociales, Université Abou Bekr Belkaïd de Tlemcen, Algérie; Centre national de recherches préhistoriques, anthropologique et historique (Station de Tlemcen)., Chabni Nafissa ,   Cancerlab et Sercice d’Epidémilologie et Démographie, Otmani Salima ,   Laboratoire d’Anthropologie des Religions et comparaison, Faculté des Sciences Humaines et Sociales, Université Abou Bekr Belkaïd de Tlemcen, Algérie., Belkhatir Djamel ,   Laboratoire de valorisation de l’action de l’homme pour la protection de l’environnement et application en santé publique (équipe environnement et santé), Faculté des Sciences, Université Abou Bekr Belkaïd de Tlemcen, Algérie., Sahi Majda ,   Laboratoire de valorisation de l’action de l’homme pour la protection de l’environnement et application en santé publique (équipe environnement et santé), Faculté des Sciences, Université Abou Bekr Belkaïd de Tlemcen, Algérie., Sidi-Yakhlef Adel ,   Laboratoire d’Anthropologie des Religions et comparaison, Faculté des Sciences Humaines et Sociales, Université Abou Bekr Belkaïd de Tlemcen, Algérie., Benkou Fatiha ,   Laboratoire d’Anthropologie des Religions et comparaison, Faculté des Sciences Humaines et Sociales, Université Abou Bekr Belkaïd de Tlemcen, Algérie., Bachir Saïd ,   Laboratoire de valorisation de l’action de l’homme pour la protection de l’environnement et application en santé publique (équipe environnement et santé), Faculté des Sciences, Université Abou Bekr Belkaïd de Tlemcen, Algérie.
Published: May 2022

In this study, the results of the analysis of blood group polymorphism (ABO, Rhesus, MNSs, Duffy) in a sample of 200 individual hens from the coastal population of Honaïne (Western Algeria) are presented. From an ethnic point of view this population belongs to the Berber tribe of the Koumia established in the Traras mountains before the 16th century. The results obtained showed that the four systems are in Hardy-Weinberg equilibrium. Compared to the populations of the Mediterranean basin, our population is characterized by a high frequency of Rh*cde haplotype and Fy * o allele. The inter-population relations studied using genetic distances of the blood groups and the phylogenetic tree showed a great affinity between the hen population of Honaїne and the hen populations of North Africa.
Susceptibilidade a antimicrobianos de bactérias isoladas de leite caprino em Sergipe, Brasil
Authors: Rizzo Huber Huber , Carrillo Gaeta Natália , Andrade Coelho Ramon , Ribeiro Alves da Silva Caíque , Katiele Souza de Jesus Taile , Livingstone Felizola Soares de Andrade Rachel
Published: May 2022

Introdução:  A resistência bacteriana é parte fundamental da Saúde Única, definida como a união humana indissociável entre as saúdes animal, e ambiental. produto, pelo consumo epidemiológica a disseminação de resistência bacteriana em animais, seus produtos são apresentados são alimentos vista carne, e podem apresentar-se por meio da cadeia de produção de alimentos pela manipulação faça o alimentos vista carne. Em virtude da resistência da informação, faz com que a caracterização da epidemia não seja necessária. Sendo assim, o objetivo deste trabalho foi determinar uma frequência e o perfil de sensibilidade a bactérias antimicrobianas isoladas de amostras de municípios de estado de Sergipe.
Discussão : A E. coli, foi a espécie mais frequente nas amostras. É considerado um patógeno ambiental, e sua alta frequência nos diferentes rebanhos indica higiene de ordem precária. E. coli também se destaca como uma espécie que mais apresentou isolados multidroga resistentes (MDR; 50%), com cepas resistentes a beta-lactâmicos, aminoglicosídeos, quinolonas, tetraciclinas e cloranfenicol. Os estafilococos coagulase negativas (SCN) são reconhecidos publicamente como um problema de saúde, já que são agentes etiológicos de várias enfermidades e têm facilidade de adquirirem genes de resistência a antimicrobianos. Embora não tenha sido a espécie mais isolada, S. aureusfoi a segunda espécie com maior frequência de cepas MDR. A presença de espécies MDR é relevante e alerta uma necessidade de ações urgentes para aumentar a disseminação da antimicrobianos, uma resistência para ser de maneira conjunta por profissionais na saúde humana, animal e ambiental.
Rhabdomyosarcoma with unknown primary tumor site. A report from European Pediatric Soft Tissue Sarcoma Study Group (EpSSG)
Authors: Affinita Maria Carmen , Merks Johannes , Chisholm Julia , haouy stephanie , Rome Angélique , Rabusin Marco , Brennan Bernadette , Bisogno Gianni
Published: May 2022

BACKGROUND: Rhabdomyosarcoma (RMS) is an aggressive malignancy, and 20%
of children present with metastases at diagnosis. Patients presenting
with disseminated disease very occasionally have no clear evidence of a
primary tumor mass. Since these patients have rarely been investigated,
we report on a series of patients with RMS and unknown primary tumor
site registered in the MTS 2008 protocol (October 2008 - December 2016)
coordinated by the European pediatric Soft tissue sarcoma Study Group.
METHODS: Patients were administered 9 cycles of induction chemotherapy,
and 48 weeks of maintenance chemotherapy. Surgery and/or radiotherapy
was planned after the first assessment of tumor response, and
implemented after six cycles of chemotherapy. If feasible, radiotherapy
to all sites of metastasis was recommended. RESULTS: We identified 10
patients with RMS and unknown primary site, most of them adolescents
(median age 15.8 years, range 4.6-20.4). Nine had fusion-positive
alveolar RMS. Multiple organ involvement was identified in 7 patients, 2
only had bone marrow disease, and 1 only had leptomeningeal
dissemination. All patients were given chemotherapy, 4 were irradiated,
and none had surgery. Three patients underwent allogeneic bone marrow
transplantation. At the time of this analysis, only 2 patients are alive
in complete remission: 1 had received radiotherapy; and 1 had a bone
marrow transplant. CONCLUSIONS: RMS with unknown primary tumor occurs
mainly in adolescents and is typically fusion-positive alveolar.
Radiotherapy may be important, but survival is poor and patients should
be offered enrollment in investigational trials.
LITTLE GREEN MEN: O EPISÓDIO DE DETECÇÃO DOS PULSARES E O PROTAGONISMO DE JOCELYN BELL BURNELL
Authors: Pires Larissa Do Nascimento , Peduzzi Luiz O. Q.
Published: May 2022

No ano de 1967, a então estudante de pós-graduação Jocelyn Bell identificou sinais pulsados de ondas de rádio, que posteriormente puderam corroborar observacionalmente a existência das estrelas de nêutrons. Neste trabalho, desenvolvemos um estudo histórico-epistemológico sobre o episódio de detecção dos pulsares a partir de relatos elaborados por Jocelyn Bell Burnell e por seu orientador, Antony Hewish, e de pesquisas que se debruçaram sobre este tema. Na análise epistemológica, consideramos, predominantemente, aspectos da filosofia da ciência de Thomas Kuhn e Norwood Hanson. Os resultados chamam atenção para o papel da serendipidade em uma descoberta científica e para a importância do trabalho coletivo em um período de ciência normal, que neste caso propiciaram novos estudos teóricos e observacionais para a compreensão deste novo objeto astronômico. Ressaltamos que a discussão da serendipidade e do acaso no contexto de ensino de ciências pode contribuir para desmistificar ideias equivocadas sobre este conceito, favorecendo uma melhor compreensão da natureza do conhecimento científico. O trabalho também possibilita evidenciar o protagonismo de uma mulher cientista em um importante episódio científico.
EVASÃO E PERSISTÊNCIA ESTUDANTIL EM CURSOS DE GRADUAÇÃO DAS ÁREAS DE CIÊNCIAS E MATEMÁTICA: UMA REVISÃO DA LITERATURA
Authors: Franco Bianca Vasconcelos do Evangelho , Moraes Kaluti Rossi de Martini , Espinosa Tobias , Heidemann Leonardo Albuquerque
Published: May 2022

O objetivo da presente revisão da literatura é apresentar um perfil das pesquisas sobre evasão e persistência em cursos de graduação das áreas de Ciências e Matemática, identificando as principais razões pelas quais os estudantes descontinuam ou permanecem em seus estudos, bem como as principais orientações de ações institucionais propostas nas publicações em periódicos nacionais e do exterior. Os 95 trabalhos analisados foram selecionados a partir da plataforma Scopus e dos motores de busca de 63 periódicos nacionais. Os resultados apontam predominância da metodologia quantitativa nas pesquisas, escassa adoção de referenciais teóricos, polissemia conceitual e ausência de justificativas para o endereçamento da problemática. A partir da análise dirigida pela lente sociológica de Vincent Tinto, as razões para a saída dos estudantes estão fortemente relacionadas com fatores individuais (e.g., metas, crenças e motivações), mas também há fatores relacionados com a interação no ambiente universitário (e.g., integração dos estudantes, desempenho acadêmico). Ademais, as principais orientações para ação institucional apontam para a importância do suporte acadêmico, social e financeiro, com destaque para a implementação de orientações acadêmicas aos estudantes e provisão de bolsas em programas institucionais.
ATIVIDADE EXPERIMENTAL PROBLEMATIZADA (AEP): ASSERÇÕES PRAXIOLÓGICAS E PEDAGÓGICAS AO ENSINO EXPERIMENTAL DAS CIÊNCIAS
Authors: Ferreira Marcello , Silva André Luis Silva da , Silva Filho Olavo Leopoldino da , Portugal Khalil Oliveira
Published: May 2022

Com foco nas perspectivas praxiológica e pedagógica, foram demarcadas contribuições, a partir da abordagem denominada Atividade Experimental Problematizada (AEP) a processos de ensino de ciências, visando à aprendizagem significativa e ao desenvolvimento de pensamentos de ordem superior (crítico, criativo e curioso) em comunidades investigativas de estudantes. A partir da fundamentação e caracterização de ilustração em tema da física, verifica-se na AEP condições satisfatórias para abordar didaticamente conteúdos científicos a partir de problemáticas motivadoras, além de possibilitar reflexões acerca da natureza da ciência e de sua empiria e abstrações. Ao abranger articuladores e momentos próprios, a AEP corresponde a uma sistematização de ensino investigativo, voltada à aprendizagem significativa, autônoma, permeada por habilidades de raciocínio, formação de conceitos, investigação e tradução, e a uma concepção sócio-histórica e cultural da ciência. Por fim, a metodologia busca engendrar condições de existência e de avaliação de processos educacionais que subsidiem tal práxis, mediando a alfabetização científica e o desenvolvimento crítico.
A EDUCAÇÃO EM CIÊNCIAS E A TEORIA DOS CAPITAIS DE BOURDIEU: UMA REVISÃO CRÍTICA DO CONCEITO DE SCIENCE CAPITAL
Authors: Moris Carlos Henrique Aparecido Alves , Massi Luciana , Nascimento Matheus Monteiro
Published: May 2022

A teoria de Bourdieu, ainda que não predominante, tem sido usada para fundamentar trabalhos na educação em ciência que buscam inserir a dimensão social nas discussões da área. Contudo, as ciências da natureza não receberam um foco direto na bibliografia de Bourdieu. Baseado nessa lacuna, o conceito de science capital foi proposto como um agregador dos aspectos das ciências nos capitais de Bourdieu. Ainda que já utilizado na literatura inglesa da área, esse conceito parece ter alguns distanciamentos com a teoria bourdiana. Assim, propomos realizar uma revisão crítica, baseada na teoria de Bourdieu, sobre a proposta e usos do science capital, por meio de uma revisão bibliográfica sistemática. Com base nos resultados, o novo conceito parece se fundar em uma leitura substancialista que concebe, a priori, valores sociais para determinadas práticas e disposições relacionadas à ciência, tendendo a não questionar as relações de poder vigentes; o que entendemos como um distanciamento com a teoria bourdiana. Contudo, ressaltamos que o science capital apresenta a potencialidade de mobilizar um foco nas desigualdades sociais associadas à ciência na área de educação em ciências. Concluímos reafirmando que essa potencialidade pode ser ampliada se buscarmos repensar o science capital por uma perspectiva não substancialista.
Euler sums of generalized harmonic numbers and connected extensions
Authors: Can Mümün , Kargın Levent , Dil Ayhan , Soylu Gültekin
Published: May 2022

This paper presents the evaluation of the Euler sums of generalized
hyper-harmonic numbers Hn(p,q) in terms of the famous Euler sums of
generalized harmonic numbers. Moreover, several infinite series, whose terms
consist of certain harmonic numbers and reciprocal binomial coefficients,
are evaluated in terms of the Riemann zeta values.
Apoptosis induction in HeLa cervical cancer cell line by steroidal 16,17-seco-16,17a-dinitriles
Authors: Aleksic Lidija , Nikolic Andrea , Kojic Vesna , Sakac Marija , Jovanovic-Santa Suzana
Published: May 2022

Steroids are good candidates for drug development, thanks to their low general toxicity and possibility for structure modifications connected with change of their activity. Several 16,17-secoandrost-4-ene-16,17a-dinitrile compounds were synthesized and screened for anticancer effect previously, including 6-oxo and 6-hydroxyimino compounds. This research is continued with the attempts for different synthetic strategy and evaluation of anticancer effect mechanism. Synthesis of 3-hydroxyimino compounds was successful, but inseparable mix of isomers was excluded from biological tests. Tested secodinitriles expressed cytotoxic effect on HeLa cervix cancer cells as a model system, with submicromolar to molar IC50 values, where 6-substituted derivatives were more effective. After 72 h treatment with equitoxic concentrations equal IC50 values of test compounds the mechanism of this effect was studied using flow cytometry and specific fluorescent dyes. Modest change in both G0/G1 and G2/M resting phases and change in mitochondrial membrane potential were noticed, while the most pronounced effect was apoptosis induction. Total apoptosis was in range 50.72?58.31 % in all cell samples treated with secodinitriles, compared to 7.44 % in control samples. Total percent of dead cells, including both apoptotic and necrotic, ranged from 55.24 to 65.34 %, compared to 10.68 % in control. Selectivity towards cancer cells is very important feature of these compounds indicating their potential use as lead compounds in the drug development for the treatment of cancers of steroid hormone-dependent tissues.
Aesthetic Outcome of Propranolol vs Atenolol Treatment of Children with Infantile Haemangioma
Authors: Hermans Mireille M. , Breugem Corstiaan C. , Schappin Renske , Jonge Poerink Emma , Mendels Elodie J. , Ragamin Aviël , Breur Johannes M.P.J. , Langeveld Hester R. , Raphael Martine F. , De Laat Peter C.J. , De Wildt Saskia N. , Rietman André B. , Pasmans Suzanne G.M.A. , De Graaf Marlies
Published: May 2022

Infantile haemangiomas are common benign tumours of infancy, which can be treated effectively with beta-blockers such as propranolol and atenolol. Different types of beta-blockers may result in different long-term aesthetic outcomes. This study evaluated the difference in long-term aesthetic outcomes between infantile haemangiomas treated with either propranolol or atenolol, including the perspective of physicians, parents, and children. Children, aged ≥6 years, treated with propranolol or atenolol for infantile haemangioma during infancy, participated in this 2-centre cross-sectional study. The primary endpoint was change in appearance of the infantile haemangioma from pre-treatment to follow-up, using a physician-rated visual analogue scale (VAS). Secondary outcomes were the Patient Observer Scar Assessment Scale (physician- and parent-rated) and a VAS (child-rated), assessing the residual lesion. In total, 103 children (35 treated with propranolol, 68 with atenolol) were analysed. No differences were found between children treated with propranolol and children treated with atenolol on physician-rated VAS (p = 0.10) or any secondary outcomes. Physicians indicated a large aesthetic improve-ment from pre- treatment to follow-up. Physicians, parents and children were positive about the current state of the residual lesion. Minor sequelae were common (86%). These results, in combination with the favourable safety profile of atenolol, should be considered when choosing beta-blocker treatment for infantile haemangioma.
Features of the behavior of seismically isolated railway bridges at seismic impacts of various levels
Authors:   Saint Petersburg State University of Architecture and Civil Engineering, Kondratieva L. N. , Nesterova O. P. ,   Saint Petersburg State University of Architecture and Civil Engineering, Dolgaya A. A. ,   AO «TRANSMOST», Shermukhamedov U. Z. ,   Tashkent State Transport University
Published: May 2022

The paper considers the behavior of the railway bridge abutment in the event of an earthquake of different magnitudes. Three levels of earthquake impacts are considered: design earthquake, moderate earthquake and maximum design earthquake. The impacts of different magnitudes were specified by synthetic accelerograms and accelerograms of earthquakes which took place in the past. For comparison, three variants of supporting the span structure on the abutment are considered: rigid, on non-optimally selected seismic isolation, on optimally selected seismic isolation. Longitudinally movable supporting parts in the form of a package of flexible rods of LLC «Stroykompleks-5» company are used as seismic isolation.
Problems of technical regulation in the sphere of building materials
Authors:   Saint Petersburg State University of Architecture and Civil Engineering, Staroverov V. D. , Dmitriev A. L. ,   Saint Petersburg State University of Architecture and Civil Engineering, Kuvshinov E. A. ,   Saint Petersburg State University of Architecture and Civil Engineering
Published: May 2022

To facilitate the development of the construction industry, it is necessary to timely issue new standards and to revise the existing ones. However, several problems in the field of technical regulation have been revealed associated with the unwillingness to apply scientific and practical methods in the development of standards and the lack of a hierarchical system of standardized requirements and methods of controlling them. In this regard, the fund of normative construction documents is characterized by unreasonable growth due to the presence of duplicate standards and an excessive number of identical standards for testing methods applied to homogeneous products. Also, the quality of the standards themselves is not up to date: there are ambiguous interpretations, and the requirements and methods are not pre-approved in the industry scientific organizations, which makes it difficult to implement them in the activities of various laboratories. Ultimately, his has a negative impact on the reliability of the obtained product test results and, consequently, can raise the level of risk to the impartiality of the laboratories. There are regarded the problems of standardization on examples of regulatory documents on crushed stone, curbstone, bituminous materials, materials for road markings, as well as suggested ways of solving these problems.
Determinants of tourism attractiveness for Taiwan’s offshore islands
Authors: Ding Ji-Feng , Tseng Yen-Cheng , Wang Tsung-Yen
Published: May 2022

Evaluating the influence factors of the attractiveness of offshore island tourism will help to understand customers’ motivations in choosing tourism activities, and for the travel operators to improve their promotion of tourism products. This paper employed the fuzzy analytic hierarchy process method to empirically analyze the determinants of tourism attractiveness of Taiwan’s offshore islands. The results indicate that the ‘substantial aspect’ is the most important evaluation dimension on offshore island tourism attractiveness. Among the 16 influence factors, the ‘natural resources of regional attractions,’ ‘cultural heritage and cultural resources,’ and ‘well-established and convenient transportation’ are the most three determinants about the tourism attractiveness of Taiwan’s offshore islands. Furthermore, some discussions concerning the key determinates are provided for Taiwan’s offshore tourism.