bluuebunny/crossref_metadata_2025 huggingface dataset:
Insights on the cycling behavior of a highly-prelithiated silicon–graphite electrode in lithium-ion cells
Authors: Rodrigues Marco-Tulio F , Gilbert James A , Kalaga Kaushik , Abraham Daniel P
Published: January 2020

Nanosized silicon materials are being developed for use in the anodes of high-energy lithium-ion batteries. However, the high surface areas of these materials increase the rate of parasitic reactions in the electrode, which consume cyclable Li+ and degrade battery performance. Prelithiation offers a realistic strategy to compensate for this reactivity, by injecting additional charge into the cell to counterbalance the Li+ loss. Interestingly, the benefits offered by prelithiation extend beyond its more obvious purpose. Here, by using a reference electrode in NMC532//Si–Gr cells, we show how prelithiation alters the cycling potentials experienced by the Si-containing anode and how that translates into gains in cycle life. The rate of consumption of the prelithiated charge is lower than that expected from the behavior of non-prelithiated cells. Curiously, the Si particles become partially unresponsive during the C/3 cycling apparently because of kinetic constraints. Electrochemical studies on harvested electrodes in half-cells show that capacities are intact after the long-term cycling and that most of the lithium reservoir is still present in the anode. We conclude that the high capacity retention displayed by the prelithiated cells mainly results from a higher participation of graphite particles during the extended electrochemical cycling.
The Eighth Day of Creation: looking back across 40 years to the birth of molecular biology and the roots of modern cell biology
Authors: Peifer Mark
Published: January 2020

Forty years ago, Horace Judson’s The Eighth Day of Creation was published, a book vividly recounting the foundations of modern biology, the molecular biology revolution. This book inspired many in my generation. The anniversary provides a chance for a new generation to take a look back, to see how science has and hasn’t changed. Many central players in the book, including Sydney Brenner, Seymour Benzer, and François Jacob, would go on to be among the founders of modern cell biology, developmental biology, and neurobiology. These players come alive via their own words, as complex individuals, both heroes and anti-heroes. The technologies and experimental approaches they pioneered, ranging from cell fractionation to immunoprecipitation to structural biology, and the multidisciplinary approaches they took continue to power and inspire our work today. In the process, Judson brings out of the shadows the central roles played by women in many of the era’s discoveries. He provides us with a vision of how science and scientists have changed, of how many things about our endeavor never change, and of how some new ideas are perhaps not as new as we would like to think.
Saving the Vicuña: The Political, Biophysical, and Cultural History of Wild Animal Conservation in Peru, 1964–2000
Authors: Wakild Emily
Published: January 2020

This article examines national efforts to protect wildlife in the twentieth century. Its focus is the vicuña, a small llama-like species native to the Andes, which nearly went extinct due to the high economic value of its wool. Instead, the Peruvian national government—despite significant regime shifts—intervened to put in place and then perpetuate a series of conservation measures, including trade restrictions and a territorial reserve, that protected the population and allowed it to rebound. Using a combination of cultural, economic, political, and biological methods to understand the animals and people concerned about them, this article argues that conservation reoriented relationships among people and wild animals. Cultural affinities led to ethical claims about the animal’s value as well as utilitarian arguments about its potential economic worth for community and economic development. Moreover, the vicuña themselves shaped both the landscapes and the conservation programs with their biological habits. Saving the vicuña proved to be a complex social process that challenged facile assumptions about past environmental actions of politically volatile, economically marginalized, and socially divided nations.
EP3: an ensemble predictor that accurately identifies type III secreted effectors
Authors: Li Jing , Wei Leyi , Guo Fei , Zou Quan
Published: January 2020

Type III secretion systems (T3SS) can be found in many pathogenic bacteria, such as Dysentery bacillus, Salmonella typhimurium, Vibrio cholera and pathogenic Escherichia coli. The routes of infection of these bacteria include the T3SS transferring a large number of type III secreted effectors (T3SE) into host cells, thereby blocking or adjusting the communication channels of the host cells. Therefore, the accurate identification of T3SEs is the precondition for the further study of pathogenic bacteria. In this article, a new T3SEs ensemble predictor was developed, which can accurately distinguish T3SEs from any unknown protein. In the course of the experiment, methods and models are strictly trained and tested. Compared with other methods, EP3 demonstrates better performance, including the absence of overfitting, strong robustness and powerful predictive ability. EP3 (an ensemble predictor that accurately identifies T3SEs) is designed to simplify the user’s (especially nonprofessional users) access to T3SEs for further investigation, which will have a significant impact on understanding the progression of pathogenic bacterial infections. Based on the integrated model that we proposed, a web server had been established to distinguish T3SEs from non-T3SEs, where have EP3_1 and EP3_2. The users can choose the model according to the species of the samples to be tested. Our related tools and data can be accessed through the link http://lab.malab.cn/∼lijing/EP3.html.
Regularized Bayesian transfer learning for population-level etiological distributions
Authors: Datta Abhirup , Fiksel Jacob , Amouzou Agbessi , Zeger Scott L
Published: January 2020

Computer-coded verbal autopsy (CCVA) algorithms predict cause of death from high-dimensional family questionnaire data (verbal autopsy) of a deceased individual, which are then aggregated to generate national and regional estimates of cause-specific mortality fractions. These estimates may be inaccurate if CCVA is trained on non-local training data different from the local population of interest. This problem is a special case of transfer learning, i.e., improving classification within a target domain (e.g., a particular population) with the classifier trained in a source-domain. Most transfer learning approaches concern individual-level (e.g., a person’s) classification. Social and health scientists such as epidemiologists are often more interested with understanding etiological distributions at the population-level. The sample sizes of their data sets are typically orders of magnitude smaller than those used for common transfer learning applications like image classification, document identification, etc. We present a parsimonious hierarchical Bayesian transfer learning framework to directly estimate population-level class probabilities in a target domain, using any baseline classifier trained on source-domain, and a small labeled target-domain dataset. To address small sample sizes, we introduce a novel shrinkage prior for the transfer error rates guaranteeing that, in absence of any labeled target-domain data or when the baseline classifier is perfectly accurate, our transfer learning agrees with direct aggregation of predictions from the baseline classifier, thereby subsuming the default practice as a special case. We then extend our approach to use an ensemble of baseline classifiers producing an unified estimate. Theoretical and empirical results demonstrate how the ensemble model favors the most accurate baseline classifier. We present data analyses demonstrating the utility of our approach.
Endogenous Selection Bias and Cumulative Inequality over the Life Course: Evidence from Educational Inequality in Subjective Well-Being
Authors: Kratz Fabian , Patzina Alexander
Published: January 2020

According to theories of cumulative (dis-)advantage, inequality increases over the life course. Labour market research has seized this argument to explain the increasing economic inequality as people age. However, evidence for cumulative (dis-)advantage in subjective well-being remains ambiguous, and a prominent study from the United States has reported contradictory results. Here, we reconcile research on inequality in subjective well-being with theories of cumulative (dis-)advantage. We argue that the age-specific endogenous selection of the (survey) population results in decreasing inequalities in subjective well-being means whereas individual-level changes show a pattern of cumulative (dis-)advantage. Using repeated cross-sectional data from the European Social Survey (N = 15,252) and employing hierarchical age-period-cohort models, we replicate the finding of decreasing inequality from the United States with the same research design for Germany. Using panel data from the German Socio-Economic Panel Study (persons = 47,683, person-years = 360,306) and employing growth curve models, we show that this pattern of decreasing inequality in subjective well-being means is accompanied by increasing inequality in intra-individual subjective well-being changes. This pattern arises because disadvantaged groups, such as the low educated and individuals with low subjective well-being show lower probabilities of continuing to participate in a survey and because both determinants reinforce each other. In addition to allowing individual changes and attrition processes to be examined, the employed multi-cohort panel data have further key advantages for examining inequality in subjective well-being over the life course: They require weaker assumptions to control for period and cohort effects and make it possible to control for interviewer effects that may influence the results.
The reduction of source effect for reliable estimation of geomagnetic transfer functions
Authors: Ernst Tomasz , Nowożyński Krzysztof , Jóźwiak Waldemar
Published: January 2020

SUMMERY

We have analysed the literature suggestions regarding possible changes in vertical magnetic transfer function (VTF) over time. We have shown that for periods above 1500 s the observed changes in VTF are caused by the source effect and we proposed how to reduce this negative impact. For calculations we used 1-min recordings of geomagnetic variations registered between 2002 and 2017 in various geomagnetic observatories. In data processing we used frequency-domain Egbert's algorithm and our original algorithm based on the method of least squares in the time domain for some comparisons and tests. We have shown that for periods over 1500 s the VTFs calculated separately from summer and winter data are different. However, our analysis shows that the variability of the VTF values obtained is misleading and results from time-changing presence of magnetic field variations that do not fulfill the assumption of plane wave (there is a vertical component in the incident magnetic field). These variations are much more numerous in summer than in winter. More detailed analysis has shown also that they are usually small at night and big during the day. The vertical components of these variations constitute an error correlated with input signals (horizontal components), which alters the values of the determined VTF. Furthermore, error bars do not take this effect into account. It makes it impossible to improve the accuracy of calculations by increasing the amount of data. Analysing the estimated external parts of vertical components from the Central European observatories we noticed a great similarity of these signals even if the induction components were clearly different, which indicates that this is a regional effect. On this basis, we proposed a procedure to improve the accuracy of VTF determination by means of pre-selection of data.
Impact of model inconsistencies on reconstructions of past mantle flow obtained using the adjoint method
Authors: Colli L , Bunge H-P , Oeser J
Published: January 2020

The adjoint method is a powerful technique to compute sensitivities (Fréchet derivatives) with respect to model parameters, allowing one to solve inverse problems where analytical solutions are not available or the cost to determine many times the associated forward problem is prohibitive. In Geodynamics it has been applied to the restoration problem of mantle convection—that is, to reconstruct past mantle flow states with dynamic models by finding optimal flow histories relative to the current model state—so that poorly known mantle flow parameters can be tested against observations gleaned from the geological record. By enabling us to construct time dependent earth models the adjoint method has the potential to link observations from seismology, geology, mineral physics and palaeomagnetism in a dynamically consistent way, greatly enhancing our understanding of the solid Earth system. Synthetic experiments demonstrate for the ideal case of no model error and no data error that the adjoint method restores mantle flow over timescales on the order of a transit time (≈100 Myr). But in reality unavoidable limitations enter the inverse problem in the form of poorly known model parameters and uncertain state estimations, which may result in systematic errors of the reconstructed flow history. Here we use high-resolution, 3-D spherical mantle circulation models to perform a systematic study of synthetic adjoint inversions, where we insert on purpose a mismatch between the model used to generate synthetic data and the model used for carrying out the inversion. By considering a mismatch in rheology, final state and history of surface velocities we find that mismatched model parameters do not inhibit misfit reduction: the adjoint method still produces a flow history that fits the estimated final state. However, the recovered initial state can be a poor approximation of the true initial state, where reconstructed and true flow histories diverge exponentially back in time and where for the more divergent cases the reconstructed initial state includes physically implausible structures, especially in and near the thermal boundary layers. Consequently, a complete reduction of the cost function may not be desirable when the goal is a best fit to the initial condition. When the estimated final state is a noisy low-pass version of the true final state choosing an appropriate misfit function can reduce the generation of artefacts in the initial state. While none of the model mismatches considered in this study, taken singularly, results in a complete failure of the recovered flow history, additional work is needed to assess their combined effects.
Provincializing the International: Communist Print Worlds in Colonial India
Authors: Raza Ali
Published: January 2020

This paper charts communist print worlds in colonial India during the interwar period. Beginning in the early 1920s, self-declared ‘Communist’ and ‘Bolshevik’ publications began surfacing across India. Through the example of the Kirti Kisan Sabha (Workers and Peasants Party: a communist group in the north-western province of Punjab), and its associated publications, this paper will provide a glimpse into the rich, diverse and imaginative print worlds of Indian communism. From 1926 onwards, Kirti publications became a part of a thriving print culture in which a dizzying variety of revolutionary, socialist and communist publications competed and conversed with the equally prolific and rich print worlds of their political and ideological rivals. Removed on the one hand from the ivory towers of party intellectuals, dense treatises and officious theses, and on the other hand from the framing of sedition, rebellion and fanaticism in the colonial archive, Kirti publications show how the global project of communist internationalism became distinctly provincialized and vernacularized in British India.
Validation of the Reveal® 3-D for Peanut Lateral Flow Test: AOAC Performance Tested MethodSM 111901
Authors: Le Quynh-Nhi , Vance Alexis , Bakir Nawal , Almy Dave , Slenk Emily , Roman Brooke , Klass Nicole , Bastin Benjamin , Donofrio Robert
Published: January 2020

Background

Reveal® 3-D for Peanut is an immunochromatographic, lateral flow test for qualitative detection of peanut residue in food manufacturing and food preparation settings. The test can detect low ppm levels of peanut in clean-in-place (CIP) rinses and in swabs from environmental surfaces and can serve as a tool in managing allergen risk.

Objective

The objective of the study was to validate the lateral flow method for detection of peanut in CIP rinses, specifically water, peroxyacetic acid/hydrogen peroxide, and quaternary ammonium compound rinses, and in swabs taken from stainless steel and plastic surfaces.

Methods

CIP rinses spiked with low levels of peanut were tested, as were surfaces inoculated with peanut. Specificity and assay interference were assessed in testing of food commodities with and without added peanut. Assay robustness and test kit stability and consistency testing were also performed.

Results

Results demonstrated that the lateral flow test can detect peanut in CIP rinses in the range of 2–4 ppm and in environmental surface swabs in the range of 3–4 µg/100 cm2. Results of specificity testing with 29 common food items showed lack of cross-reactivity, and potential assay interference only from walnut. Data from stability trials supports expiration dating for the kit of up to 23 months post-manufacture.

Conclusions and Highlights

The lateral flow test is a sensitive, specific, and rapid method for detection of low levels of peanut residue in CIP rinses and environmental samples and can be an important component in a comprehensive allergen risk management program.
Betrayal in War: Rules and Trends on Seeking Collaboration under IHL
Authors: Galvis Martínez Manuel
Published: January 2020

The article analyses the legal regime applicable to military operations seeking to gain the collaboration of enemy elements under International Humanitarian Law (IHL). Apart from addressing the prima facie legality of these practices, the article addresses some trends forming in state practice regarding limitations to its general permission. Throughout the review of academic opinions, treaty provisions, state practice and examples from armed conflicts, the author evaluates the evolution of the legal framework applicable to such tactics and provides some possible interpretations that can guide the developing process of the conduct of hostilities in the near future.
The Many Lines of Defense: The Political Economy of US Defense Acquisition
Authors: Gholz Eugene , Sapolsky Harvey M
Published: January 2020

Political economy infuses the process that generates military power, notably including weapons acquisition. In the United States, defense acquisition follows a dynamic balance of interests among the private companies that design and build weapons, the military services that use weapons, and the legislators that appropriate money to pay for weapons. That process belies the simplistic conventional wisdoms that explain acquisition as a direct result of strategic need or as dictated by a unified military-industrial complex. A political economy approach that recognizes the complexity of interests—public and private, expert and political—best explains what weapons get built, by whom, where, and when.
Estradiol-inducible AvrRps4 expression reveals distinct properties of TIR-NLR-mediated effector-triggered immunity
Authors: Ngou Bruno Pok Man , Ahn Hee-Kyung , Ding Pingtao , Redkar Amey , Brown Hannah , Ma Yan , Youles Mark , Tomlinson Laurence , Jones Jonathan D G
Published: January 2020

Plant nucleotide-binding domain, leucine-rich repeat receptor (NLR) proteins play important roles in recognition of pathogen-derived effectors. However, the mechanism by which plant NLRs activate immunity is still largely unknown. The paired Arabidopsis NLRs RRS1-R and RPS4, that confer recognition of bacterial effectors AvrRps4 and PopP2, are well studied, but how the RRS1/RPS4 complex activates early immediate downstream responses upon effector detection is still poorly understood. To study RRS1/RPS4 responses without the influence of cell surface receptor immune pathways, we generated an Arabidopsis line with inducible expression of the effector AvrRps4. Induction does not lead to hypersensitive cell death response (HR) but can induce electrolyte leakage, which often correlates with plant cell death. Activation of RRS1 and RPS4 without pathogens cannot activate mitogen-associated protein kinase cascades, but still activates up-regulation of defence genes, and therefore resistance against bacteria.
Linking zonal winds and gravity: the relative importance of dynamic self-gravity
Authors: Wicht Johannes , Dietrich Wieland , Wulff Paula , Christensen Ulrich R
Published: January 2020

Recent precise measurements of Jupiter’s and Saturn’s gravity fields help constraining the properties of the zonal flows in the outer envelopes of these planets. The link is provided by a simplified dynamic equation, which connects zonal flows to related buoyancy perturbations. These can result from density perturbations but also from the gravity perturbations. Whether the latter effect, which we call dynamic self-gravity (DSG), must be included or is negligible has been a matter of intense debate. We show that the second-order differential equation for the gravity perturbations becomes an inhomogeneous Helmholtz equation when assuming a polytrope of index unity for density and pressure. This equation can be solved semi-analytically when using modified spherical Bessel functions for describing the radial dependence. The respective solutions allow us to quantify the impact of the DSG on each gravity harmonic, practically independent of the zonal flow or the details of the planetary interior model. We find that the impact decreases with growing spherical harmonic degree ℓ. For degrees ℓ = 2 to about ℓ = 4, the DSG is a first-order effect and should be taken into account in any attempt of inverting gravity measurements for zonal flow properties. For degrees of about ℓ = 5 to roughly ℓ = 10, the relative impact of DSG is about 10 per cent and thus seems worthwhile to include, in particular since this comes at little extra cost with the method presented here. For yet higher degrees, it seems questionable whether gravity measurements or interior models will ever reach the precision required for disentangling the small DSG effects, which amount to only a few per cent at best.
Searching for optical companions to four binary millisecond pulsars with the Gran Telescopio Canarias
Authors: Kirichenko A Yu , Karpova A V , Zyuzin D A , Zharikov S V , López E A , Shibanov Yu A , Freire P C C , Fonseca E , Cabrera-Lavers A
Published: January 2020

We report on multiband photometric observations of four binary millisecond pulsars with the Gran Telescopio Canarias. The observations led to detection of binary companions to PSRs J1630+3734, J1741+1351, and J2042+0246 in the Sloan g′, r′, and i′ bands. Their magnitudes in the r′ band are ≈24.4, 24.4, and 24.0, respectively. We also set a 3σ upper limit on the brightness of the PSR J0557+1550 companion in the r′ band of ≈25.6 mag. Combining the optical data with the radio timing measurements and white dwarf cooling models, we show that the detected companions are cool low-mass white dwarfs with temperatures and ages in the respective ranges of (4–7) × 103 K and 2–5 Gyr. All the detected white dwarfs are found to likely have either pure hydrogen or mixed helium–hydrogen atmospheres.
mstar – a fast parallelized algorithmically regularized integrator with minimum spanning tree coordinates
Authors: Rantala Antti , Pihajoki Pauli , Mannerkoski Matias , Johansson Peter H , Naab Thorsten
Published: January 2020

We present the novel algorithmically regularized integration method mstar for high-accuracy (|ΔE/E| ≳ 10−14) integrations of N-body systems using minimum spanning tree coordinates. The twofold parallelization of the $\mathcal {O}(N_\mathrm{part}^2)$ force loops and the substep divisions of the extrapolation method allow for a parallel scaling up to NCPU = 0.2 × Npart. The efficient parallel scaling of mstar makes the accurate integration of much larger particle numbers possible compared to the traditional algorithmic regularization chain (ar-chain) methods, e.g. Npart = 5000 particles on 400 CPUs for 1 Gyr in a few weeks of wall-clock time. We present applications of mstar on few particle systems, studying the Kozai mechanism and N-body systems like star clusters with up to Npart = 104 particles. Combined with a tree or fast multipole-based integrator, the high performance of mstar removes a major computational bottleneck in simulations with regularized subsystems. It will enable the next-generation galactic-scale simulations with up to 109 stellar particles (e.g. $m_\star = 100 \, \mathrm{M}_\odot$ for an $M_\star = 10^{11} \, \mathrm{M}_\odot$ galaxy), including accurate collisional dynamics in the vicinity of nuclear supermassive black holes.
Centrifugal acceleration of protons by a supermassive black hole
Authors: Istomin Ya N , Gunya A A
Published: January 2020

Centrifugal acceleration is due to the rotating poloidal magnetic field in the magnetosphere that creates the electric field which is orthogonal to the magnetic field. Charged particles with finite cyclotron radii can move along the electric field and receive energy. Centrifugal acceleration pushes particles to the periphery, where their azimuthal velocity reaches the speed of light. We calculated particle trajectories by numerical and analytical methods. The maximum obtained energies depend on the parameter of the particle magnetization κ, which is the ratio of rotation frequency of magnetic field lines in the magnetosphere ΩF to non-relativistic cyclotron frequency of particles ωc, κ = ΩF/ωc <<1, and on the parameter α which is the ratio of toroidal magnetic field BT to the poloidal one BP, α = BT/BP. It is shown that for small toroidal fields, α < κ1/4, the maximum Lorentz factor γm is only the square root of magnetization, γm = κ−1/2, while for large toroidal fields, α > κ1/4, the energy increases significantly, γm = κ−2/3. However, the maximum possible acceleration, γm = κ−1, is not achieved in the magnetosphere. For a number of active galactic nuclei, such as M87, maximum values of Lorentz factor for accelerated protons are found. Also, for special case of Sgr. A*, estimations of the maximum proton energy and its energy flux are obtained. They are in agreement with experimental data obtained by HESS Cherenkov telescope.
Lessons from a blind study of simulated lenses: image reconstructions do not always reproduce true convergence
Authors: Denzel Philipp , Mukherjee Sampath , Coles Jonathan P , Saha Prasenjit
Published: January 2020

In the coming years, strong gravitational lens discoveries are expected to increase in frequency by two orders of magnitude. Lens-modelling techniques are being developed to prepare for the coming massive influx of new lens data, and blind tests of lens reconstruction with simulated data are needed for validation. In this paper, we present a systematic blind study of a sample of 15 simulated strong gravitational lenses from the EAGLE suite of hydrodynamic simulations. We model these lenses with a free-form technique and evaluate reconstructed mass distributions using criteria based on shape, orientation, and lensed image reconstruction. Especially useful is a lensing analogue of the Roche potential in binary star systems, which we call the lensing Roche potential. This we introduce in order to factor out the well-known problem of steepness or mass-sheet degeneracy. Einstein radii are on average well recovered with a relative error of ${\sim }5{{\ \rm per\ cent}}$ for quads and ${\sim }25{{\ \rm per\ cent}}$ for doubles; the position angle of ellipticity is on average also reproduced well up to ±10°, but the reconstructed mass maps tend to be too round and too shallow. It is also easy to reproduce the lensed images, but optimizing on this criterion does not guarantee better reconstruction of the mass distribution.
The optically selected 1.4-GHz quasar luminosity function below 1 mJy
Authors: Malefahlo Eliab , Santos Mario G , Jarvis Matt J , White Sarah V , Zwart Jonathan T L
Published: January 2020

We present the radio luminosity function (RLF) of optically selected quasars below 1 mJy, constructed by applying a Bayesian-fitting stacking technique to objects well below the nominal radio flux density limit. We test the technique using simulated data, confirming that we can reconstruct the RLF over three orders of magnitude below the typical 5σ detection threshold. We apply our method to 1.4-GHz flux densities from the Faint Images of the Radio Sky at Twenty-Centimeters (FIRST) survey, extracted at the positions of optical quasars from the Sloan Digital Sky Survey over seven redshift bins up to z = 2.15, and measure the RLF down to two orders of magnitude below the FIRST detection threshold. In the lowest redshift bin (0.2 < z < 0.45), we find that our measured RLF agrees well with deeper data from the literature. The RLF for the radio-loud quasars flattens below $\log _{10}[L_{1.4}/{\rm W\, Hz}^{-1}] \approx 25.5$ and becomes steeper again below $\log _{10}[L_{1.4}/{\rm W\, Hz}^{-1}] \approx 24.8$, where radio-quiet quasars start to emerge. The radio luminosity where radio-quiet quasars emerge coincides with the luminosity where star-forming galaxies are expected to start dominating the radio source counts. This implies that there could be a significant contribution from star formation in the host galaxies, but additional data are required to investigate this further. The higher redshift bins show a similar behaviour to the lowest z bin, implying that the same physical process may be responsible.
Optimizing gravitational waves follow-up using galaxies stellar mass
Authors: Ducoin J-G , Corre D , Leroy N , Le Floch E
Published: January 2020

We present a new strategy to optimize the electromagnetic follow-up of gravitational wave triggers. This method is based on the widely used galaxy targeting approach where we add the stellar mass of galaxies in order to prioritize the more massive galaxies. We cross-matched the Galaxy List for the Advanced Detector Era (GLADE) galaxy catalogue with the AllWISE catalogue up to 400 Mpc with an efficiency of ∼93 per cent, and derived stellar masses using a mass-to-light ratio using the WISE1 band luminosity. We developed a new grade to rank galaxies combining their 3D localization probability associated with the gravitational wave event with the new stellar mass information. The efficiency of this new approach is illustrated with the GW170817 event, which shows that its host galaxy, NGC 4993, is ranked at the first place using this new method. The catalogue, named MANGROVE, is publicly available and the ranking of galaxies is automatically provided through a dedicated website for each gravitational wave event.
XMM–Newton campaign on ultraluminous X-ray source NGC 1313 X-1: wind versus state variability
Authors: Pinto C , Walton D J , Kara E , Parker M L , Soria R , Kosec P , Middleton M J , Alston W N , Fabian A C , Guainazzi M , Roberts T P , Fuerst F , Earnshaw H P , Sathyaprakash R , Barret D
Published: January 2020

Most ultraluminous X-ray sources (ULXs) are thought to be powered by neutron stars and black holes accreting beyond the Eddington limit. If the compact object is a black hole or a neutron star with a magnetic field ≲1012 G, the accretion disc is expected to thicken and launch powerful winds driven by radiation pressure. Evidence of such winds has been found in ULXs through the high-resolution spectrometers onboardXMM–Newton, but several unknowns remain, such as the geometry and launching mechanism of these winds. In order to better understand ULX winds and their link to the accretion regime, we have undertaken a major campaign with XMM–Newton to study the ULX NGC 1313 X-1, which is known to exhibit strong emission and absorption features from a mildly relativistic wind. The new observations show clear changes in the wind with a significantly weakened fast component (0.2c) and the rise of a new wind phase which is cooler and slower (0.06–0.08c). We also detect for the first time variability in the emission lines which indicates an origin within the accretion disc or in the wind. We describe the variability of the wind in the framework of variable super-Eddington accretion rate and discuss a possible geometry for the accretion disc.
Evidence of spectral evolution on the white dwarf sample from the Gaia mission
Authors: Ourique G , Kepler S O , Romero A D , Klippel T S , Koester D
Published: January 2020

Since the Gaia data release 2, several works have been published describing a bifurcation in the observed white dwarf colour−magnitude diagram for ${G_{\mathrm{BP}}}{}-{G_{\mathrm{RP}}}{} \gt 0$. Some possible explanations in the literature include the existence of a double population with different initial mass functions or two distinct populations, one formed by hydrogen-envelope and one formed by helium-envelope white dwarfs. We propose instead spectral evolution to explain the bifurcation. From a population synthesis approach, we find that spectral evolution occurs for effective temperatures below ${\simeq }11\, 000\, \mathrm{K}$ and masses mainly between $0.64\, \mathrm{M}_\odot$ and $0.74\, \mathrm{M}_\odot$, which correspond to around 16 per cent of all DA white dwarfs. We also find that the Gaia white dwarf colour–magnitude diagram indicates a star formation history that decreases abruptly for objects younger than $1.4\, \mathrm{Gyr}$ and a top-heavy initial mass function for the white dwarf progenitors.
Metallicity has followed local gravitational potential of galaxies since z = 3
Authors: Møller P , Christensen L
Published: January 2020

The MZ relation between stellar mass (M*) and metallicity (Z) of nearby galaxies has been described as both a global and local property, i.e. valid also on sub-galaxy scales. Here, we show that Z has remained a local property, following the gravitational potential, since z = 3. In absorption, the MZ relation has been well studied, and was in place already at z = 5.1. A recent absorption study of gamma-ray burst galaxies revealed a close match to damped Lyα (DLA) galaxies, surprising due to their vastly different impact parameters and leading the authors to suggest that local metallicity follows the local gravitational potential. In this paper, we formulate an observational test of this hypothesis. The test, in essence, forms a prediction that the velocity dispersion of the absorbing gas in galaxy haloes, normalized by the central velocity dispersion, must follow a steep log scale slope of −0.015 dex $\rm kpc^{-1}$ as a function of impact parameter out to at least 20–30 kpc. We then compile an archival data and literature-based sample of galaxies seen in both emission and absorption suitable for the test, and find that current data confirm the hypothesis out to 40–60 kpc. In addition, we show that the distribution of the velocity offsets between zem and zabs favours a model where DLA systems are composed of individual sub-clouds distributed along the entire path through the halo, and disfavours a model where they are one single cloud with a bulk motion and internal sub-structure.
Independent Losses of the Hypoxia-Inducible Factor (HIF) Pathway within Crustacea
Authors: Graham Allie M , Barreto Felipe S
Published: January 2020

Metazoans respond to hypoxic stress via the hypoxia-inducible factor (HIF) pathway, a mechanism thought to be extremely conserved due to its importance in monitoring cellular oxygen levels and regulating responses to hypoxia. However, recent work revealed that key members of the HIF pathway have been lost in specific lineages (a tardigrade and a copepod), suggesting that this pathway is not as widespread in animals as previously assumed. Using genomic and transcriptomic data from 70 different species across 12 major crustacean groups, we assessed the degree to which the gene HIFα, the master regulator of the HIF pathway, was conserved. Mining of protein domains, followed by phylogenetic analyses of gene families, uncovered group-level losses of HIFα, including one across three orders within Cirripedia, and in three orders within Copepoda. For these groups, additional assessment showed losses of HIF repression machinery (EGLN and VHL). These results suggest the existence of alternative mechanisms for cellular response to low oxygen and highlight these taxa as models useful for probing these evolutionary outcomes.
Understanding the effect of controlling phosphorothioate chirality in the DNA gap on the potency and safety of gapmer antisense oligonucleotides
Authors: Østergaard Michael E , De Hoyos Cheryl L , Wan W Brad , Shen Wen , Low Audrey , Berdeja Andres , Vasquez Guillermo , Murray Susan , Migawa Michael T , Liang Xue-hai , Swayze Eric E , Crooke Stanley T , Seth Punit P
Published: January 2020

Therapeutic oligonucleotides are often modified using the phosphorothioate (PS) backbone modification which enhances stability from nuclease mediated degradation. However, substituting oxygen in the phosphodiester backbone with sulfur introduce chirality into the backbone such that a full PS 16-mer oligonucleotide is comprised of 215 distinct stereoisomers. As a result, the role of PS chirality on the performance of antisense oligonucleotides (ASOs) has been a subject of debate for over two decades. We carried out a systematic analysis to determine if controlling PS chirality in the DNA gap region can enhance the potency and safety of gapmer ASOs modified with high-affinity constrained Ethyl (cEt) nucleotides in the flanks. As part of this effort, we examined the effect of systematically controlling PS chirality on RNase H1 cleavage patterns, protein mislocalization phenotypes, activity and toxicity in cells and in mice. We found that while controlling PS chirality can dramatically modulate interactions with RNase H1 as evidenced by changes in RNA cleavage patterns, these were insufficient to improve the overall therapeutic profile. We also found that controlling PS chirality of only two PS linkages in the DNA gap was sufficient to modulate RNase H1 cleavage patterns and combining these designs with simple modifications such as 2′-OMe to the DNA gap resulted in dramatic improvements in therapeutic index. However, we were unable to demonstrate improved potency relative to the stereorandom parent ASO or improved safety over the 2′-OMe gap-modified stereorandom parent ASO. Overall, our work shows that while controlling PS chirality can modulate RNase H1 cleavage patterns, ASO sequence and design are the primary drivers which determine the pharmacological and toxicological properties of gapmer ASOs.
Universal Basic Income
Authors: Mulvale James P.
Published: January 2020

Universal basic income (UBI) is an approach to income security that guarantees every individual in a political community (be it a nation or a subnational unit such as a state, province, or municipality) an unconditional and sufficient income to meet their basic needs, such as food, shelter, clothing, transportation, and the other necessities of life. UBI differs from state-sponsored social insurance schemes that became widespread in welfare states during latter half of the 20th century. Social insurance is funded by mandatory employer and/or employee contributions, and is tied to specific events affecting workers, such as loss of paid employment, parenting a new child, or retirement from the labor force. UBI also differs from last-resort income support programs such as social assistance (often called “welfare” or “workfare”). Such programs are meant to respond to those in immediate and dire financial need. Qualifying for social assistance depends on proving one’s eligibility to government officials through an application process that is typically complicated, demeaning, and stigmatizing. Social assistance often requires certain behaviors of recipients, such as participation in life-skills training or (in the case of workfare) work in low-skill jobs at low pay. In contrast, UBI is available to everyone on an unconditional basis, with no requirement for advance contributions, no stigma attached to those receiving it, and no work or other behavioral requirements. The Basic Income Earth Network defines UBI in this way: “A basic income is a periodic cash payment unconditionally delivered to all on an individual basis, without means-test or work requirement.” Basic income has the following five characteristics: (1) Periodic: paid at regular intervals (for example, every month), not as a one-off grant. (2) Cash payment: paid in an appropriate medium of exchange, allowing those who receive it to decide what they spend it on. It is not, therefore, paid either in kind (such as food or services) or in vouchers dedicated to a specific use. (3) Individual: paid on an individual basis—and not, for instance, to households. (4) Universal: paid to all, without a means test. (5) Unconditional: paid without a requirement to work or to demonstrate willingness-to-work. Basic income (or approximations thereof) often go by different names, such as guaranteed income, citizens’ income, unconditional cash transfer, refundable tax credits, or social dividend.
State-Society Relations in South Asia
Authors: Ray Subhasish
Published: January 2020

South Asia, a region comprising roughly one-fifth of the world’s population, is home to some of the most diverse nations in the contemporary world, encompassing social cleavages across multiple dimensions. A critical facet of this diversity is that it has persisted, even as state-builders, starting from the precolonial period, have sought to impose the writ of centralized authority to make such diversity legible and governable. Not surprisingly, therefore, the region offers a fascinating vantage point for social scientists to develop and test theories of a range of state-society linkages and how these reconstitute our understandings of both “state” and “society.” This bibliography aims to provide a window into this continuously evolving body of research. As with any such endeavor, it is not possible to capture the vast depth and breadth of this research within the confines of a single work. Hence, the goal here is to introduce academics and policy practitioners to some of the key conceptual developments and empirical findings in the field. In what follows, the cited works have been classified under the following headings: (i) Capital-State Linkages, (ii) Labor-State Linkages, (iii) Land-State Linkages, (iv) Party-State Linkages, (v) Region-State Linkages, (vi) Caste-State Linkages, (vii) Migrant-State Linkages, (viii) Gender-State Linkages, (ix) Breakdown of State-Society Relations, and (x) Law and State-Society Relations. This schematic was adopted to underscore the sheer variety of social actors and institutions that impinge on the exercise of state power in the region. The concluding section offers an overview of the core academic Journals in the field.
Repatriation
Authors: Krmpotich Cara
Published: January 2020

Repatriation is the return of persons, material heritage, and/or associated knowledge to its place of origins. Within anthropology, this frequently refers to the return of items collected and held within museums or other institutional collections to originating communities. Origins and originating communities are variously identified as nation-states, Indigenous or ethnic groups, kin groups, cities or villages, or sites of removal. It is repatriation from cultural institutions, as opposed to battlefield repatriation or repatriation of displaced persons, that the bibliography focuses on. Anthropology is well into its second generation of focused repatriation scholarship, whereas the material culture and human remains at the heart of repatriation requests have frequently had a much longer place in anthropological research. Many items now returning through repatriation processes were originally collected and made objects of study by anthropologists and archaeologists. During the formation of anthropology and archaeology as disciplines, museums, material culture (see the separate Oxford Bibliographies article Material Culture), and physical anthropology were central. Collecting, documenting, and measuring the physical bodies and material heritage of cultural groups were understood by anthropologists to generate data, while museums were sites where comparative analysis could occur, training of students happened, and emerging theories could be presented to scholars and the public alike. Given this history, it is unsurprising that anthropologists have been actively engaged in scholarly debate about the repatriation of materials (whether ethnographic or otherwise), as well as participants in the development of institutional policies, national legislation, and public understanding. In the contemporary moment, anthropologists frequently find themselves working with Indigenous peoples who are vying to hold colonial and settler nations to account for injustice, and who are asserting the viability and legitimacy of their cultural practices into the future. Repatriating ancestral remains and material heritage is one form of redress and expression of sovereignty for many nations and cultural groups. Thus, repatriation is increasingly understood as an expression of contemporary Indigeneities and nationalisms, pushing anthropologists to ask what roles repatriation—and museums more broadly—play in processes of decolonization, reconciliation, indigenization, and nation-building.