bluuebunny/crossref_metadata_2025 huggingface dataset:
Filli Café: Experience Tea and Talk
Authors: Jham Vimi
Published: November 2022

Filli Café in the United Arab Emirates (UAE) has captured a slice of the market with the unique taste of zafran tea. This was superimposed by applying a unique branding strategy. The brand’s unique selling proposition was to create a homely ambience at Filli Café, where people could chat for hours while immersed in the joy of a warm, soothing cup of tea. This led to the brand’s huge success, with the target audience being the expatriates and Emirati population, as they liked the taste of the zafran tea. The challenge in front of the Chief Executive Officer, Mr Rafih Filli, was to grab the market and work on diversification and expansion globally.
Family violence and family law property division: How can the system be improved?
Authors: Kaye Miranda
Published: November 2022

This article explores how the economic impacts of violence can continue long after a relationship has ended and how the family law system is a generally unhelpful tool for financial recovery from abuse. Hurdles in the legal system such as the unavailability of legal aid and the absence of affordable legal representation, lack of legislative reforms in relation to property division in cases of violence, and difficulties in enforcing orders, compound experiences of violence and entrench poverty. Reforms to improve the family law property system for victims of violence are suggested.
Factors Associated With Survival in Patients With End-of-Life Hematological Malignancies Who Received Chemotherapy: A Retrospective Single-Institution Study
Authors: Iizuka-Honma Hiroko , Mitsumori Toru , Yoshikawa Seiichiro , Takizawa Haruko , Noguchi Masaaki
Published: November 2022

Background

Clinicians can appropriately terminate treatment or reduce treatment intensity by determining prognostic factors of end-of-life chemotherapy. In particular, it provides important information for patients with hematological malignancies who receive chemotherapy until near-the-end of life compared with patients with solid tumors. This study aimed to clarify whether existing prognostic tools are associated with the survival in patients with end-of-life hematological malignancies who received chemotherapy.

Methods

We retrospectively reviewed the records of 247 patients diagnosed with hematological malignancies and died at our university hospital hematology ward between May 2015 and May 2021. We performed multivariate analysis in 82 (33.2%) patients who received end-of-life chemotherapy using the Palliative Prognostic Index (PPI) and inflammation-based prognostic models, such as the Glasgow Prognostic Score (GPS), Prognostic Nutritional Index (PNI), and Controlling Nutrition Status (CONUT).

Results

On comparing 82 patients who received end-of-life chemotherapy with 165 patients who did not, the proportion of patients with PPI group A, GPS score = 0, and CONUT normal/mild was significantly higher among patients who received chemotherapy. In multivariate analysis, we identified PPI groups B (2.0 < PPI ≤ 4.0) and C (PPI > 4.0) [hazard ratio (HR) 2.1290, 95% CI 1.1830-3.828, P = .01166, respectively] and age ≥ 65 years (HR 2.0170, 95% CI 1.1280-3.607, P = .01805) were associated with overall survival.

Conclusion

PPI use and age were independent associating factors for patients with hematological malignancies receiving end-of-life chemotherapy. PPI, a popular prognostic tool may be helpful for patients and hematologists to make decisions about end-of-life care.
Early-Term Results of the Cadence Total Ankle Prosthesis: An European Noninventor Study
Authors: Malherbe Corentin , Deleu Paul-André , Devos Bevernage Bernhard , Birch Ivan , Maldague Pierre , Gombault Vincent , Putzeys Pit , Leemrijse Thibaut
Published: November 2022

Background:

Although considerable literature can be found on the outcome of total ankle replacement (TAR), only a few studies have reported the results of the fixed-bearing Cadence prosthesis. This noninventor study reports a consecutive series of 60 Cadence TAR systems with a mean of 2.9 years’ follow-up, focusing on clinical and radiographic outcomes and early complications. This study is the first to assess true postoperative radiographic ankle prosthesis range of motion (ROM) and to report an unanticipated serious adverse device effect.

Methods:

Sixty patients who underwent primary TAR with the Cadence prosthesis between July 2016 and July 2019 were clinically and radiographically evaluated preoperatively and at last follow-up after the procedure. Revisions, additional procedures, implant failure, and complications were reported according to the classifications of Vander Griend and Glazebrook. Radiographic outcomes included radiographic TAR ROM, bone-implant interface, and alignment parameters.

Results:

The survival rate of the prosthesis was 98.3%. The mean radiographic ankle ROM at the last follow-up was 24 degrees (9 degrees of dorsiflexion and 15 degrees of plantarflexion). The coronal and sagittal alignment of TAR was 90.8 degrees and 3.9 degrees, respectively. Bone-implant interface analysis revealed osteolysis in 9 ankles (15%) and radiolucent lines in 33 ankles (55%) occurring at both component interfaces. Intraoperative complications were 3 periprosthetic malleolar fractures (5%). Five talar implant fractures (implant failure of 8.3%) were observed, and 1 unexplained persistent pain that required a conversion from TAR to a tibiotalocalcaneal arthrodesis.

Conclusion:

Clinical, radiograph ROM, implant position outcomes, and survival rate at an early-term follow-up of 2.9 years were similar to those reported in recent Cadence studies. However, this study reports 5 unanticipated talar implant fractures and a high rate of posterior radiolucent lines.

Level of evidence:

Level IV, retrospective case series.
Trajectories of Preventive Health Care Utilization Among Older Koreans: The Role of Social Relationships
Authors: Jung Yunkyung , Choi Sunha
Published: November 2022

Background

Receiving timely health screening is associated with important public health benefits among older adults. By focusing on the role of social relationships, the present study was aimed at examining longitudinal trajectories of health screening use among older adults in Korea, whose universal health care system provides free-of-charge health screening.

Methods

A nationally representative sample of 3,575 individuals aged 65 or older from wave one of the Korean Longitudinal Study of Aging (2006) was followed for 10 years (up to Wave 6, 2016). Mixed-effect logit models were used to investigate how an older adult’s social relationship characteristics (i.e., household composition, financial support from family, social group participation, and the frequency of contact with friends or relatives) were associated with their trajectories of participation in the national health screening program.

Results

Despite the low financial burden, only 49.7% of older adults in Korea reported receiving the recommended health screening at the baseline. Although the probability of receiving recommended health screening increased over the 10-year study period, the trajectories were significantly different by an older adult’s social relationship characteristics. All four social relationship characteristics were significantly associated with receiving health screening. However, those with more frequent social contacts and those who participated in social groups showed steeper increases in the probability of receiving health screening (i.e., significant interaction with time).

Conclusions

This study highlights the importance of social relationships and intervention approaches that accommodate socially isolated older adults to facilitate their timely receipt of recommended preventive care.
Climate Variability Patterns and Farmers’ Perceptions of Its Impact on Food Production: A Case Study of the Gelda Watershed in the Lake Tana Basin in Northwest Ethiopia
Authors: Anteneh Mesfin
Published: November 2022

This study looked at patterns of erratic climate and farmer perceptions in the Gelda watershed of Lake Tana Basin in northwestern Ethiopia. The National Meteorological Agency of Ethiopia provided essential climatic data for the period between 1981 and 2011. A household survey and focus group discussions were also used to understand about local communities’ perceptions of climate variability and its impact on food production. Time series trend analysis of observed rainfall and temperature conditions was detected using linear regression analysis. To compare the means of climatic parameters and determine whether the average difference was significantly different from zero, the paired sampled t-test was used. The study found that the average annual temperature trend increased by 1.1°C, while the amount and distribution of annual and monthly rainfall decreased, varied across the catchment, and fluctuated during the study periods (1981–2011) at mean temperature rise with an average rate of 0.17°C in the last decade. The variability of annual and monthly rainfall in terms of intensity and distribution has decreased and varied across the watershed. The analysis revealed that annual rainfall variability was variable in the upper catchment (CV > 11.7%) and lower catchment (CV > 14.4%). The amount and intensity of temperature, on the other hand, increased throughout the study watershed, despite observed variation both spatially and temporally (stated decades). Farmers’ understanding and expression of climate variability in terms of erratic rainfall distribution, decreasing amount, and increasing temperature over the last three decades, however, matched the observed data. Moreover, farmers are pointed out that high population pressure; deforestation and intensified agriculture are responsible factors for the variability of climate in the study watershed. Therefore, based on the findings, scientist and policymakers has to design appropriate adaptation measures that can tackle the aggravation of climate variability for future.
Feelings of (eco-) grief and sorrow: climate activists as emotion entrepreneurs
Authors: Holthaus Leonie
Published: November 2022

This article conceives of climate activists as emotion entrepreneurs to explain the emergence of particular emotional responses to climate change. Among these emotional responses is eco-grief or grief felt because of experienced or anticipated ecological losses. I elaborate on the concept of the emotion entrepreneur and theorize the emergence of eco-grief on the basis of a practice theoretical and Bourdieusian approach. I suggest that activists possessing cultural capital are well positioned to introduce new feelings and identify three mechanisms that contribute to explanations of the emergence and growing importance of eco-grief. Objectivation is about the most often reflexive practice of giving names to emotions to turn them into ontological entities. Cultivation is about the creation of social spaces for the experience and regulation of eco-grief among activists. Diffusion is about emotional contagion, the creation of emotional vocabularies, and the spread of activist feeling rules. Research on emotion entrepreneurs moves beyond conceptions of feelings as causes of activism and suggests there is a need for further research on emotional dynamics in heterogenous transnational advocacy coalitions, influences of language on emotions, and feelings rules in late-modern Western societies.
A basic identification of late auditory evoked potentials at infrasound frequencies: Support via neural network–based signal processing
Authors: Koch Christian
Published: November 2022

Concerns about potential health risks from infrasound exposure require objective investigation methods for the perception of infrasound by humans. Neural-network methods were applied to identify weak infrasound evoked potentials and to investigate the efficacy of these techniques. Two simple networks – a fully connected three-layer feed-forward network and a two-layer autoencoder – were designed for the analysis of electroencephalography (EEG) data recorded in response to infrasound stimuli presented. Late auditory evoked potentials (LAEPs) were detected and correlation factors between the target and the output of the networks were determined to assess the differentiation ability of the two networks. Both networks were able to differentiate infrasound evoked potentials from noise but showed different performance levels with respect to a differentiation threshold. The results can be applied to objectively identify perception events by infrasound in humans.
As the twig is bent, the tree is inclined? The role of parental versus own education for openness towards globalisation
Authors: Kunst Sander , Kuhn Theresa , van de Werfhorst Herman G
Published: November 2022

Citizens with higher levels of education are consistently found to be more open to immigration and European integration than those with less education. However, the literature has neglected the issue of whether educational divides in anti-globalisation sentiment result from people's own educational attainment or whether they are a consequence of deep-rooted positions of disadvantage across generations. In this article, we address the question to what extent the attitudes towards globalisation of intergenerationally mobile citizens, that is, those who obtain a different educational outcome than one's parents, adapt to the newly acquired social position or remain attached to the parental milieu. We apply diagonal reference models to study the influence of one's own and parental education level on attitudes to globalisation in 26 European countries using the European Social Survey between 2008 and 2018. Our results indicate that while mobile citizens adjust their attitudes to the achieved education level, there remains an enduring influence of the education level of origin. In addition, we find that the importance of parental educational attainment does not depend on the social fluidity between education levels within countries. Consequently, this study has important implications for studying political socialisation and the future of the educational divide over globalisation.
Analysing the business model canvas of the camping industry using cluster analysis
Authors: Grande Kevin , Camprubi Raquel
Published: November 2022

Private and public camping businesses are struggling with the strategic and operational management of their establishments. Current research on the camping sector is scarce, whether related to campsite management or existing business models. This paper aims to identify the groups of business models in the camping industry, categorize camping businesses, and enable a better understanding of the factors distinguishing the different business models by proposing key financial and non-financial indicators. Thus, a Business Model Canvas approach is applied to a set of 52 currently operating camping businesses, and a cluster analysis used to explore key factors. Findings reveal several camping business profiles, and the conclusions outline managerial implications.
Monarchy and the peculiarities of the English
Authors: Turner Bryan S
Published: November 2022

This article describes how the monarchy has enjoyed historical continuity in a society that has not been invaded since 1066 and had no revolutionary experience unlike other European nations. The other peculiarity includes the confusion about ‘the British Isles’, ‘Great Britain’ and ‘England’. Britain is best understood as a fragmented archipelago of societies. Queen Elizabeth II managed to survive the peculiarities and two major crises: the dismissal of the Australian Prime Minister Gough Whitlam and the death of Lady Diana.
Focused Ultrasound Stimulation of Microbubbles in Combination With Radiotherapy for Acute Damage of Breast Cancer Xenograft Model
Authors: Sharma Deepa , Hussein Farah , Law Niki , Farhat Golnaz , Tarapacki Christine , Sannachi Lakshmanan , Giles Anoja , Czarnota Gregory J.
Published: November 2022

Objective: Several studies have focused on the use of ultrasound-stimulated microbubbles (USMB) to induce vascular damage in order to enhance tumor response to radiation. Methods: In this study, power Doppler imaging was used along with immunohistochemistry to investigate the effects of combining radiation therapy (XRT) and USMB using an ultrasound-guided focused ultrasound (FUS) therapy system in a breast cancer xenograft model. Specifically, MDA-MB-231 breast cancer xenograft tumors were induced in severe combined immuno-deficient female mice. The mice were treated with FUS alone, ultrasound and microbubbles (FUS  +  MB) alone, 8 Gy XRT alone, or a combined treatment consisting of ultrasound, microbubbles, and XRT (FUS  +  MB  +  XRT). Power Doppler imaging was conducted before and 24 h after treatment, at which time mice were sacrificed and tumors assessed histologically. The immunohistochemical analysis included terminal deoxynucleotidyl transferase dUTP nick end labeling, hematoxylin and eosin, cluster of differentiation-31 (CD31), Ki-67, carbonic anhydrase (CA-9), and ceramide labeling. Results: Tumors receiving treatment of FUS  +  MB combined with XRT demonstrated significant increase in cell death (p  =  0.0006) compared to control group. Furthermore, CD31 and Power Doppler analysis revealed reduced tumor vascularization with combined treatment indicating ( P < .0001) and ( P  =  .0001), respectively compared to the control group. Additionally, lesser number of proliferating cells with enhanced tumor hypoxia, and ceramide content were also reported in group receiving a treatment of FUS  +  MB  +  XRT. Conclusion: The study results demonstrate that the combination of USMB with XRT enhances treatment outcomes.
Development and Validation of a Prognostic Model to Predict Overall Survival for Lung Adenocarcinoma: A Population-Based Study From the SEER Database and the Chinese Multicenter Lung Cancer Database
Authors: Wang Zhiqiang , Hu Fan , Chang Ruijie , Yu Xiaoyue , Xu Chen , Liu Yujie , Wang Rongxi , Chen Hui , Liu Shangbin , Xia Danni , Chen Yingjie , Ge Xin , Zhou Tian , Zhang Shuixiu , Pang Haoyue , Fang Xueni , Zhang Yushuang , Li Jin , Hu Kaiwen , Cai Yong
Published: November 2022

Background: Lung adenocarcinoma (LUAD) is the most common subtype of non-small-cell lung cancer (NSCLC). The aim of our study was to determine prognostic risk factors and establish a novel nomogram for lung adenocarcinoma patients. Methods: This retrospective cohort study is based on the Surveillance, Epidemiology, and End Results (SEER) database and the Chinese multicenter lung cancer database. We selected 22,368 eligible LUAD patients diagnosed between 2010 and 2015 from the SEER database and screened them based on the inclusion and exclusion criteria. Subsequently, the patients were randomly divided into the training cohort (n = 15,657) and the testing cohort (n = 6711), with a ratio of 7:3. Meanwhile, 736 eligible LUAD patients from the Chinese multicenter lung cancer database diagnosed between 2011 and 2021 were considered as the validation cohort. Results: We established a nomogram based on each independent prognostic factor analysis for 1-, 3-, and 5-year overall survival (OS) . For the training cohort, the area under the curves (AUCs) for predicting the 1-, 3-, and 5-year OS were 0.806, 0.856, and 0.886. For the testing cohort, AUCs for predicting the 1-, 3-, and 5-year OS were 0.804, 0.849, and 0.873. For the validation cohort, AUCs for predicting the 1-, 3-, and 5-year OS were 0.86, 0.874, and 0.861. The calibration curves were observed to be closer to the ideal 45° dotted line with regard to 1-, 3-, and 5-year OS in the training cohort, the testing cohort, and the validation cohort. The decision curve analysis (DCA) plots indicated that the established nomogram had greater net benefits in comparison with the Tumor-Node-Metastasis (TNM) staging system for predicting 1-, 3-, and 5-year OS of lung adenocarcinoma patients. The Kaplan–Meier curves indicated that patients’ survival in the low-risk group was better than that in the high-risk group ( P < .001). Conclusion: The nomogram performed very well with excellent predictive ability in both the US population and the Chinese population.
Sleeve-Dor Fundoplication – An Innovative Surgical Technique to Avoid the Epidemic Long Term de Novo Gastroesophageal Reflux and Barrett´s Esophagus After Sleeve Gastrectomy for Obesity
Authors: Li Renjie , Eskander Wael , Teixeira Andre F. , Zorron Ricardo
Published: November 2022

Background

Sleeve gastrectomy (SG) in current literature showed an increased risk of “de novo” gastroesophageal reflux disease (GERD) and increased risk for Barrett’s esophagus in longer follow-up series, with a possibility of esophageal adenocarcinoma in this population. Adding primarily an anterior Dor Fundoplication to SG (Sleeve-Dor) may protect the patient for future and can potentially avoid these chronic complications for patients with obesity.

Methodology

A standard SG is performed laparoscopically, and a small redundance of the fundus is maintained as a wrap, and this will be fixed to the right crura without dissection of the anatomy of the hiatus. The resulted anterior 180° Dor fundoplication is usually sufficient to relieve or to avoid reflux symptomatic.

Discussion

Based on our preliminary and literature experiences, the SG with anterior Dor fundoplication (Sleeve-Dor) procedure could provide favorable safety profile, satisfactory reflux control and good bariatric outcomes. The complication rate is lower compared to published for Nissen Sleeve or Sleeve-Rossetti technique, with no leaks or major complications recorded to date. Sleeve-Dor procedure may be a potential primary and standard surgery for morbidly obese patients, especially for patients with preoperative GERD symptoms without major findings at endoscopy.
The Role of Augmented Reality in Surgical Training: A Systematic Review
Authors: Suresh Dhivya , Aydin Abdullatif , James Stuart , Ahmed Kamran , Dasgupta Prokar
Published: November 2022

This review aims to provide an update on the role of augmented reality (AR) in surgical training and investigate whether the use of AR improves performance measures compared to traditional approaches in surgical trainees.

PUBMED, EMBASE, Google Scholar, Cochrane Library, British Library and Science Direct were searched following PRIMSA guidelines. All English language original studies pertaining to AR in surgical training were eligible for inclusion. Qualitative analysis was performed and results were categorised according to simulator models, subsequently being evaluated using Messick’s framework for validity and McGaghie’s translational outcomes for simulation-based learning.

Of the 1132 results retrieved, 45 were included in the study. 29 platforms were identified, with the highest ‘level of effectiveness’ recorded as 3. In terms of validity parameters, 10 AR models received a strong ‘content validity’ score of 2.15 models had a ‘response processes’ score ≥ 1. ‘Internal structure’ and ‘consequences’ were largely not discussed. ‘Relations to other variables’ was the best assessed criterion, with 9 platforms achieving a high score of 2. Overall, the Microsoft HoloLens received the highest level of recommendation for both validity and level of effectiveness.

Augmented reality in surgical education is feasible and effective as an adjunct to traditional training. The Microsoft HoloLens has shown the most promising results across all parameters and produced improved performance measures in surgical trainees. In terms of the other simulator models, further research is required with stronger study designs, in order to validate the use of AR in surgical training.
Mini Female Health Program for detection of non-communicable diseases in Women – In a urban teaching hospital in India
Authors: Sangu Prashanthi Vidyasagar , Balakrishna Nagalla , Challapalli Bhargav , Ravikanti Keerthana
Published: November 2022

Background:

Prevalence of non-communicable diseases (NCDs) is increasing with women affected at an early age. The Mini Female Health Program (MFHP) is a simple screening package to detect NCDs in women.

Objective:

Determine the prevalence of selected NCDs in a hospital-based outpatient setting using MFHP.

Methods:

A cross-sectional observational study was conducted in an urban teaching hospital in India. MFHP included medical history, physical examination and investigations. NCDS of interest included anaemia, thyroid disorders, hypertension, diabetes, and obesity. Analysis was performed on groups stratified by age groups (18–30, 31–40 and > 41 years). Between group comparison and association of hypertension with other variables was undertaken.

Results:

Final analysis included 468 women, of whom 49.8%, 29.9%, and 20.3% were between 18–30, 31–40, and >41 years, respectively. Central obesity was most common NCD (waist to height ratio (WHR) > 0.5 (72.7%), waist circumference (WC) > 80 cm (62.7%)) followed by generalized obesity (body mass index (BMI) > 25 kg/m2 (52.4%)), anaemia (52.6%), thyroid disorders (27.4%), hypertension (14.1%) and diabetes (5.1%). Half of the women between 18 and 30 years were either overweight (BMI: 23–25 kg/m2) or obese. Increasing age was associated with a significant increase in the prevalence of hypertension, diabetes, thyroid disorders and obesity, but not anaemia. Only 9.8% of women were without an NCD with 17.3% having one NCD and 72.8% reporting multiple NCDs. Hypertension was strongly associated with age and WHR in multivariate regression analysis.

Conclusion:

The MFHP has highlighted the high prevalence of NCDs in women, particularly in young women demonstrating the value of simple screening programme in routine clinical care.
‘But how will you ensure the objectivity of the researcher?’ Guidelines to address possible misconceptions about the ethical imperatives of community-based research
Authors: Wood Lesley , Kahts-Kramer Samantha
Published: November 2022

Many reviewers of applications for ethical approval of research at universities struggle to understand what is considered ethical conduct in community-based research (CBR). Their difficulty in understanding CBR and the ethics embedded within it is, in part, due to the exclusion of CBR from researchers’ mandatory research ethics training. After all, CBR challenges both pedagogically and epistemologically the dominant paradigm/s whose worldviews, values and inherent structures of power help sustain the status quo within academic institutions at large. Consequently, CBR ethics applications are often prolonged due to back-and-forth rebuttals. In this article, we analyse our experiences in a South African institution of the ethics approval process for our various CBR projects over the past couple of years. Data for this purpose was generated from analysis of our reflexive dialogues as well as our responses to feedback from the ethics review boards. To help support the trustworthiness of the study, we invited critical friends to a workshop to engage with our findings. We identified three main themes all associated with how the values, worldviews and approaches of CBR differ from those of the dominant research paradigm/s, that impeded on the progress of our applications through the ethics approval process. On the basis of our analysis, we offer guidelines and a participatory research checklist for university ethics review panels to help inform their evaluation of applications concerning CBR. While universities now actively promote community engagement initiatives, and since CBR is an efficacious approach to that end, we advocate for inclusion of CBR ethics in universities’ mandatory ethics training, to help address ethical concerns that impede CBR research.
Catalytic degradation of CWAs with MOF-808 and PCN-222: Toward practical application
Authors: Wu Shaoxiong , Wang Lianyuan , Zhu Haiyan , Liang Jing , Ge Liang , Li Cong , Miao Ting , Li Jian , Cheng Zhenxing
Published: November 2022

Chemical warfare agents, such as nerve agents (GD and VX) and blister agents (HD), have strong toxicities to mankind. In recent years, zirconium-based metal-organic frameworks have been found to be attractive materials for chemical warfare agent degradation. Among them, metal-organic framework-808 (MOF-808) and porous coordination network-222 (PCN-222) were the best. However, few papers pay attention to their practical application. In this work, we prepared MOF-808 and PCN-222 using water phase and organic solvothermal methods, respectively. Their performance for the catalytic degradation of chemical warfare agents under practical decontamination conditions was studied. The results showed that MOF-808 displayed a high potency for catalytic hydrolysis of VX (10,000 mg L−1) in unbuffered solution. PCN-222 exhibited weaker reactivity with a half-life ( t1/2) of 28.8 min. Their different performances might stem from the different connectivity of the Zr6 nodes and framework structures. The results illustrated that the hydrolysis of high-concentration GD required a strong alkaline buffer to neutralize the hydrolysis product of hydrofluoric acid (HF) to avoid catalyst poisoning. When H2O2 was used as the oxidant instead of O2, both zirconium-based metal-organic frameworks performed with effective catalytic potency for HD degradation without any special lighting and so was suitable for practical application, whereas the products obtained from HD, such as HDO2 and V-HDO2, still possessed vesicant toxicity. Overall, MOF-808 prepared via a water-phase synthesis performed with effective catalysis for the degradation of high-concentration VX, GD, and HD with t1/2 of < 0.5, 3.1 and 2.2 min, respectively, exhibiting its potential for practical applications.
Knockdown of DAPK1 inhibits IL-1β-induced inflammation and cartilage degradation in human chondrocytes by modulating the PEDF-mediated NF-κB and NLRP3 inflammasome pathway
Authors: Zhao Zhongyuan , Liu Wei , Cheng Gong , Dong Shengjie , Zhao Yuchi , Wu Hao , Cao Zhilin
Published: November 2022

Osteoarthritis (OA) is a common joint disease that is characterized by inflammation and cartilage degradation. Death-associated protein kinase 1 (DAPK1) is a multi-domain serine/threonine kinase and has been reported to be involved in the progression of OA. However, its role and mechanism in OA remain unclear. Here, we found the expression of DAPK1 in OA cartilage tissues was higher than that in normal cartilage tissues. The expression of DAPK1 in chondrocytes was up-regulated by IL-1β. Knockdown of DAPK1 promoted cell viability and anti-apoptotic protein expression, while it inhibited the apoptosis rate and pro-apoptotic protein expressions in IL-1β-induced chondrocytes. In addition, DAPK1 inhibition reduced the levels of inflammatory cytokines and expressions of matrix metalloproteinases (MMPs), and increased the expressions of collagen II and aggrecan. The data of mechanistic investigation indicated that the expression of pigment epithelium-derived factor (PEDF) was positively regulated by DAPK1. Overexpression of PEDF attenuated the effects of DAPK1 knockdown on IL-1β-induced cell viability, apoptosis, inflammation, and cartilage degradation. Furthermore, PEDF overexpression restored the activity of the NF-κB pathway and NLRP3 inflammasome after DAPK1 knockdown. Collectively, down-regulation of DAPK1 inhibited IL-1β-induced inflammation and cartilage degradation via the PEDF-mediated NF-κB and NLRP3 inflammasome pathways.
Current role of neuromodulation in bladder pain syndrome/interstitial cystitis
Authors: Padilla-Fernández Bárbara , Hernández-Hernández David , Castro-Díaz David M.
Published: November 2022

Neuromodulation is recommended by major international guidelines as a fourth-line treatment in bladder pain syndrome/interstitial cystitis (BPS/IC) patients after failure of behavioural, oral and intravesical pharmacological treatments, including hydrodistension. A non-systematic review of studies identified by electronic search of MEDLINE was performed with no time limitation. A narrative synthesis of the existing evidence regarding the results of sacral, tibial and pudendal nerve stimulation in the management of BPS/IC was developed. Neuromodulation in pelvic chronic pain disorders, including BPS/IC, is a useful tool for refractory patients to conventional treatments. Sacral neuromodulation may be effective in patients with BPS without Hunner’s lesions, and the effect seems to be maintained in the mid- and long-term. Posterior tibial nerve stimulation can be offered to patients with BPS/IC in the context of a multidisciplinary approach. When pudendal neuralgia is suspected, selective pudendal nerve stimulation has a high response rate. The aetiology of the pain can influence the outcomes in the mid- and long-term of the different neuromodulation approaches, thus careful diagnosis is recommended.
Susceptibility weighted imaging for qualitative grading of persistent arteriovenous shunting in deep-seated arteriovenous malformations after stereotactic radiation surgery
Authors: Hsu Charlie Chia-Tsong , Fomin Igor , Wray Bradley , Brideaux Adam , Lyons Duncan , Jaya Kumar Mahendrah , Watkins Trevor , Haacke E Mark , Krings Timo
Published: November 2022

Background and purpose

To investigate Susceptibility Weighted Imaging (SWI) signal changes in the draining vein of deep-seated arterio-venous malformations (AVMs) following stereotactic radiosurgery (SRS).

Methods and Materials

This is a retrospective study of 32 patients with deep-seated AVMs who were treated with SRS. Pre-SRS treatment and post-SRS treatment MRI were performed at 6, 12, and 24-month intervals. Deep-seated AVMs were classified based on their anatomical location and venous drainage pattern. AVM nidal volume (cm3) was estimated using the ABC/2 method. AV shunting of the AVM draining veins were graded according to its SWI signal intensity: hyperintense (grade III), mixed signal intensity (grade II), hypointense (grade I) and absent (grade 0). Conventional time-of-flight (TOF)-MRA and contrast enhanced (CE)-MRA sequences were performed to document the patency of the vein.

Results

Pre-SRS treatment AVM draining veins were either grade III 18/32 (56%) or grade II 14/32 (44%). Using mixed effects analysis, we demonstrate that each month following the SRS treatment nidal volumes decreased at the rate of 0.51 cm3/per month (CI −0.61 to (−0.40)) p =.00. Following the treatment, there was a clinically significant relationship between the signal and nidal volume: signal 0 corresponded with average nidal volume of 1.81 cm3 (CI 1.40–2.21), signal 1 with nidal volume of 2.06 cm3 (CI 1.69–2.44), signal 2 with nidal volume 2.73 cm3 (CI 2.35–3.11) and signal 3 with nidal volume 3.13 cm3 (CI 2.70–3.56) p = .00.

Conclusion

Post-SRS AVM draining veins shows a stepwise regression of the SWI signal grades which can be reliably used as a surrogate to monitor the reduction of AV shunting.
De novo appearance of cerebral microbleeds in community-dwelling older adults. Neuroimaging and clinical correlates
Authors: Del Brutto Oscar H , Recalde Bettsy Y , Rumbea Denisse A , Mera Robertino M
Published: November 2022

Background and Purpose

Prospective studies on cerebral microbleeds (CMB) have departed from individuals who already have CMB at baseline. Therefore, main outcomes have usually been the composite of new lesions appearing on the follow-up among patients who already had CMB together with those who de novo developed CMB. Using the Atahualpa Project Cohort, we aimed to assess correlates of incident CMB in community-dwelling older adults free of CMB at baseline.

Methods

Atahualpa residents aged ≥ 60 years received baseline clinical interviews and a brain MRI. Those who were free of CMB at baseline and received follow-up brain MRI at the end of the study were included. Multivariate logistic and Poisson regression models were fitted to assess the association and the incidence rate ratio (IRR) of incident CMB according to clinical and neuroimaging variables.

Results

The mean age of 241 study participants was 65.6 ± 6.1 years (57% women). After 6.5 years of follow-up, 25 subjects (10.4%) developed incident CMB. A total of 37 CMB were noticed in these 25 patients. A parsimonious logistic regression model demonstrated an association between the Edmonton Frail Scale (EFS) and incident CMB ( p = .043). Multivariate logistic regression models showed an association between WMH progression and incident CMB ( p = .011). Using Poisson regression models, the IRR for WMH progression at follow-up was increased in subjects with incident CMB ( p = .029).

Conclusions

Study results show a significant relationship between the EFS, WMH progression, and incident CMB. This knowledge will allow the implementation of preventive policies to reduce incident CMB and its consequences.
Worldwide magnitude of inguinal hernia: Systematic review and meta-analysis of population-based studies
Authors: Abebe Melese Shenkut , Tareke Amare Abera , Alem Addis , Debebe Wondwossen , Beyene Altaseb
Published: November 2022

This review pooled the magnitude of inguinal hernia based on the available population-based studies conducted throughout the world. We have searched for population-based articles reporting the magnitude of inguinal hernia on PubMed/Medline, EMBASE, Cochrane library and Google Scholar. Random-effect meta-analysis was carried out to pool the magnitude of inguinal hernia and its proportion between male and female subjects. To determine the presence of between-study heterogeneity, I2 and Cochran’s Q methods were employed. Publication bias was evaluated by the Egger test and visual examination of a funnel plot. All statistical tests were conducted by Stata version 16 software. Ten population-based studies with a total population of 51,304,093 were incorporated to pool the magnitude of inguinal hernia. The pooled prevalence of inguinal hernia was 7.7% (95% confidence interval: 6.06–9.34). Subgroup analysis showed that the highest pooled prevalence of inguinal hernia (12.72%) was observed in Asia, On the contrary, the lowest pooled prevalence emanated from America, 4.73%. The pooled prevalence of inguinal hernia in males is far higher than females. It was, respectively, 9.61% (95% confidence interval: 6.46–12.76) and 1.31% (95% confidence interval: 0.36–2.26) for males and females. The current meta-analysis revealed a higher burden of inguinal hernia. This finding glares the light that giving greater attention to inguinal hernia is required. It is recommended to identify the significant causes of inguinal hernia and design appropriate prevention as well as management strategies.
Zinc toxicosis in a cat associated with ingestion of a metal screw nut
Authors: Yu Jane , Jenkins Elizabeth , Podadera Juan M , Proschogo Nicholas , Chan Ringo , Boland Lara
Published: November 2022

Case summary

A 3-year-old female neutered domestic shorthair cat was presented for vomiting, inappetence and weight loss. The cat developed moderately regenerative anaemia, moderately increased alanine transaminase and alkaline phosphatase activities, hyperbilirubinaemia and prolonged activated partial thromboplastin time. Abdominal ultrasound identified gastric wall thickening and changes suggestive of pancreatitis. Gastroduodenoscopy identified a metal screw nut in the pylorus, which was removed with rat tooth forceps. Metal analysis and serum zinc concentration using leftover serum collected at admission were performed after screw nut removal. Serum zinc concentration was markedly elevated, confirming a diagnosis of zinc toxicosis. Metal analysis of the screw nut showed that the major metal component was zinc. The cat recovered after screw nut removal and supportive care. Clinical signs resolved and the serum zinc concentration reduced significantly after screw nut removal.

Relevance and novel information

Reports of zinc toxicosis in cats are scarce, possibly due to the more discriminating eating habits of this species. To our knowledge, this is the first report of zinc toxicosis causing haemolytic anaemia, liver enzyme activity increases, gastrointestinal signs and pancreatitis in a cat associated with ingestion of a zinc-containing metal object.
Systemic inflammation and risk of multiple sclerosis – A presymptomatic case-control study
Authors: Grut Viktor , Biström Martin , Salzer Jonatan , Stridh Pernilla , Lindam Anna , Alonso-Magdalena Lucia , Andersen Oluf , Jons Daniel , Gunnarsson Martin , Vrethem Magnus , Hultdin Johan , Sundström Peter
Published: November 2022

Background

C-reactive protein (CRP) is a marker of systemic inflammation. Increased levels of CRP in young persons have been suggested to decrease the risk of multiple sclerosis (MS).

Objectives

To assess CRP as a risk factor for MS.

Methods

Levels of CRP were measured with a high-sensitive immunoassay in biobank samples from 837 individuals who later developed MS and 984 matched controls. The risk of developing MS was analysed by conditional logistic regression on z-scored CRP values.

Results

Levels of CRP were not associated with MS risk.

Conclusions

We found no association between CRP levels and risk of MS development.
Discursive Strategies of Blaming: The Language of Judgment and Political Protest Online
Authors: Hansson Sten , Page Ruth , Fuoli Matteo
Published: November 2022

Modern politics is permeated by blame games—symbolic struggles over the blameworthiness or otherwise of various social actors. In this article, we develop a framework for identifying different strategies of blaming that protesters use on social media to criticize and delegitimize governments and political leaders. We draw on the systemic functional linguistic theory of Appraisal to distinguish between blame attributions based on negative judgments of the target’s (1) capacity, such as references to their incompetence and policy failures; (2) veracity, questioning their truthfulness or honesty via references to deceitful character or dishonest acts and utterances; (3) propriety, questioning their moral standing by references to, for instance, corruption; and (4) tenacity, suggesting that the politicians are not dependable due to, for example, dithering. We add to this a further threefold distinction based on whether blaming is focused on the target’s (1) bad character, (2) bad behavior, or (3) negative outcomes that the target either caused or did not prevent from happening. To illustrate the approach, we analyze a corpus of replies by Twitter users to tweets by British government ministers about two highly contentious issues, Covid-19 and Brexit, in 2020–2021. We suggest that the methodology outlined here could provide a useful avenue for systematically revealing and comparing a variety of realizations of blaming in large datasets of online conflict talk, thereby providing a more fine-grained understanding of the practices of protest and delegitimation in modern politics.
Is Malaysian democracy backsliding or merely staying put?
Authors: Weiss Meredith L
Published: November 2022

Observers proclaimed Malaysia's first-ever transfer of federal power through elections in 2018 as marking a democratic transition, only to see in the reversal of that change two years later evidence of backsliding. I argue instead that these concepts lack nuance: we should not read too much into a change of leadership. At best, the electoral-authoritarian regime wobbled; it neither transitioned convincingly in 2018 nor qualified as backsliding per se in 2020. That said, the regime has been edging toward liberalization, but less in the electoral sphere than in civil society and prevailing norms.
Cognitive and Affective Precursors to Decisions to use Lethal Force Against Black Suspects: A Virtual Reality Application
Authors: Tawa John , Lang Yuanguo , Jernigan Maryam M.
Published: November 2022

Here we investigated the role of physiological stress on participants' lethal force decisions with Black suspects using a novel virtual reality (VR) paradigm. We examined the conditional and mediational roles of implicit racism and visual attention to Black suspects. For this study, we filmed a series of high-risk suspect-police interactions with a 360° video camera which, when viewed through the VR headset, embeds the participants in these scenarios from the perspective of a police officer. Embedded eye tracking in the VR enabled assessment of both physiological stress (through pupil dilation) and attention (through gaze location). Analysis of these behavioral data with criminal justice majors ( N = 39) revealed a facilitative function of physiological stress for improving accuracy in lethal force decisions, specifically among those with low levels of implicit racism. Findings also indicated that dysregulated attention—characterized by either disorganized or fixated attentional patterns—compromised lethal force decision making. Results are discussed in relation to future applications of VR to inform our understanding of cognitive and affective precursors of poor decision making. Implications include the promise of cognitive-behavioral interventions for mitigating dysregulated attention patterns, ultimately towards the end of reducing unwarranted uses of lethal force against Black men and women.
Managers’ Views on Professional Competencies for Primary Health Care
Authors: Silva Luciano Bairros da , Sousa Marcos Henrique Oliveira , Íñiguez-Rueda Lupicinio
Published: November 2022

The article aimed to understand the view of managers of Primary Health Care Units about the competencies needed to exercise this function. This is qualitative research, conducted in the network of primary health care in Maceió, Alagoas, Brazil, with the participation of eight managers. Semi-structured interviews were performed, and for the treatment of the material, we used the Reflexive Thematic Analysis. The analysis resulted in the themes resulted: area of training, territorialization, work processes, and flows, emotional preparation, leadership, active posture, empathic availability, and professional self-realization. It was considered that the competencies valued by the participants fit the emphasis of the accountability model and incentives for performance. In the field of primary health care, this suggests a retraction toward the implementation of comprehensive health care practices adopted as a political guideline since the consolidation of the Unified Health System, and a reorientation of the route that goes back to the model of care centered on the individual and procedures, limiting care to biomedical care—a phenomenon that has been increasing in recent years in Brazil.