bluuebunny/crossref_metadata_2025 huggingface dataset:
Design of Strategies for the Implementation and Management of a Complementary Monetary System Using the SWOT-AHP Methodology
Authors: Lenis Escobar Alexandra , Rueda López Ramón , García Guerrero Jorge E. , Salinas Cuadrado Enrique
Published: August 2020

The objective of this research is to contribute to the scientific debate on “complementary monetary systems” (CMSs), what strategies may be the best for allowing the implementation of a CMS in a territory and that optimise the potential that it seems to have to strengthen processes of sustainable local development and urban resilience. For this, the Strengths, Weaknesses, Opportunities and Threats-Analytic Hierarchy Process methodology (SWOT-AHP) has been used, which has allowed us to identify four strategies: (1) build a social, economic and political consensus, (2) create a community observatory for “complementary social monetary systems” (CSMSs), (3) define communication tools for raising awareness and education in ethical finance and (4) promote the alignment of the CSMS with sustainable local development strategies. These strategies have been formulated so that that they can be implemented by any entity, public or private, and for any of the types of CMS that may be part of a CSMS.
Sense of Coherence and Psychological Distress Among Healthcare Workers During the COVID-19 Pandemic in Spain
Authors: Gómez-Salgado Juan , Domínguez-Salas Sara , Romero-Martín Macarena , Ortega-Moreno Mónica , García-Iglesias Juan Jesús , Ruiz-Frutos Carlos
Published: August 2020

The health crisis triggered by COVID-19 and the preventive measures taken to control it have caused a strong psychological impact on the population, especially on healthcare professionals. Risk exposure, uncertainty about how to approach the disease, care and emotional overburden, lack of resources, or unclear ever-changing protocols are, among others, psychological distress risk factors for the healthcare professionals who have faced this dramatic scenario on the front line. On the other hand, the Sense of Coherence (SOC) is a competence that could help these professionals perceive the situation as understandable, manageable, and meaningful, facilitating the activation of their resilience. This work aims to describe the levels of psychological distress and SOC of healthcare professionals during the crisis caused by COVID-19, the relationship between both variables, and their health status. A cross-sectional descriptive study with a sample of 1459 currently active healthcare workers was developed. GHQ-12 and SOC-13 were used for data collection. Bivariate analyses were performed, including Chi-Squared Test, Student’s T-Test, Analysis of Variance—ANOVA (with Bonferroni test for multiple comparisons), and correlations. Cohen’s d or Cramer’s V effect size measurements were also provided. The results showed that 80.6% of healthcare professionals had psychological distress, and the mean score on the SOC-13 scale was 62.8 points (SD = 12.02). Both psychological distress and SOC were related to the presence of COVID-19 symptoms, as well as with contact history. Professionals with psychological distress showed a lower SOC. Taking care of the mental health of healthcare professionals is essential to effectively cope with the COVID-19 pandemic. Given the psychological impact of working in the current menacing scenario, people on the front line against the disease should be protected, minimizing risks, providing them with resources and support, and fostering their coping skills.
Housing Wealth Status and Informal Accumulation of Rural Villages at the Rural-Urban Fringe in Shanghai, China
Authors: Xie Jin , Cai Yinying , Tang Hang , Liao Yuanqin
Published: August 2020

Housing wealth among urban residents has been a hotspot issue, but there is a dearth of literature focusing on rural housing wealth. Using housing registration data in Shanghai, this study examines the status and accumulation of rural housing wealth at the rural-urban fringe. Results show that rural housing wealth at the rural-urban fringe is characterized by high stock and frequent extension and reconstruction dominated by auxiliary houses. Rural housing wealth is still relatively equitable, but compared to their initial housing wealth distribution, disparities in urban villages or suburban villages are obviously higher than in the outer suburbs. These disparities are mainly driven by the expansion and reconstruction of rural auxiliary houses, typically the horizontal expansion of auxiliary homes. We suggest that defining explicit construction rules for rural auxiliary will help to avoid the disorder increase in illegal housing and, subsequently, rural housing wealth disparity.
Sustainable Water Security Based on the SDG Framework: A Case Study of the 2019 Metro Manila Water Crisis
Authors: Lee Halim , Son Jaewon , Joo Dayoon , Ha Jinhyeok , Yun Seongreal , Lim Chul-Hee , Lee Woo-Kyun
Published: August 2020

Despite being Asia’s fastest-growing economy, as of 2015, the Asian Development Bank (ADB) ranked the Philippines 33rd out of 48 countries in terms of water security. This verifies that economic development does not always lead to better provisions of basic needs. This study attempts to discover the fundamental issues that decrease water security in Metro Manila, the capital region of the Philippines. With El Niño disrupting the optimal weather conditions, Metro Manila is facing the lasting impacts of a water shortage crisis, which is the worst in the past decade. This research inspects the role of climate change in exacerbating El Niño, and its threat to the water security of the developing city. Furthermore, other factors that influence Metro Manila’s water security are discussed. Upon establishing a correlation between climate change and El Niño, Metro Manila’s general water management strategy is evaluated to better assess the multiple factors that have led to the current water shortage crisis. This paper is intended to recommend necessary and feasible proactive measures that are geared towards water security in Metro Manila, and possibly other cities with similar circumstances.
Understanding the Behaviour of Olive Oil Tourists: A Cluster Analysis in Southern Spain
Authors: Pulido-Fernández Juan Ignacio , Casado-Montilla Jairo , Carrillo-Hidalgo Isabel
Published: August 2020

Olive oil tourism is a recent development in the countries of the Mediterranean basin, but it is now spreading to other regions of the world. The main reasons people are choosing this special interest tourism (SIT) are to find out about the culture surrounding olive oil and to enjoy the whole host of activities related to the product. This has led to the creation of strong links between olive oil tourism and other types of special interest tourism. The studies undertaken thus far to characterise the profile of olive oil tourism’s demand, and its motivations, expectations and needs, have been limited and partial, focusing on specific cases. Therefore, this paper aims to take a closer look at the demand for olive oil tourism. Based on a survey of 609 visitors to olive oil mills in the south of Spain, olive oil tourists were segmented according to the type of trip and the olive oil tourism experience enjoyed during the trip, using a two-step cluster analysis. The results obtained enabled us to identify four segments with well-differentiated behaviours, which will help stakeholders, policy makers and destination managers to reach decisions, with a view to adapting their product to the expectations and needs of potential customers.
Use of EPD System for Designing New Building Materials: The Case Study of a Bio-Based Thermal Insulation Panel from the Pineapple Industry By-Product
Authors: Arellano-Vazquez Diego Armando , Moreschi Luca , Del Borghi Adriana , Gallo Michela , Islas Valverde Gustavo , Mayorga Rojas Miguel , Romero-Salazar Lorena , Arteaga-Arcos Juan Carlos
Published: August 2020

This study shows the benefits of using the environmental product declarations (EPDs), based on ISO 14025:2013, for the configuration and conceptualization of new building materials. Using a quantitative evaluation on these phases of design, it allows one to create materials with lower impacts, in comparison with the existing ones. In this paper, it is proposed to evaluate the potentiality of this tool in the development of a panel from pineapple by-products from agroindustry, used as a thermal insulator. The issue of environmental sustainability was pursued, employing the assessment of the environmental impacts according to characterization methods defined by the International EPD® System. By comparing the possible compositions of the materials under development, with certified environmental declarations of commercial materials, it is possible to identify and select optimal compositions decreasing up to 98.28% of impacts in acidification potential or up to 99.38% for photochemical oxidation—with respect to traditional materials—already at the design stage, where the changes on the composition or the facilities decision have fewer complications.
Reducing Ageism: Changes in Students’ Attitudes after Participation in an Intergenerational Reverse Mentoring Program
Authors: Leedahl Skye N. , Brasher Melanie Sereny , LoBuono Dara L. , Wood Bethany M. , Estus Erica L.
Published: August 2020

Ageism is a societal concern that greatly affects the social, emotional, physical, and mental health of older adults. One way to decrease ageist attitudes and improve the treatment of older adults is to address and improve age stereotypes among young adults. Using data from students participating in an intergenerational digital-learning program, the present study investigated change in students’ stereotypes of older adults and aging. We examined change from pre- and post-scores in student attitudes toward older adults and the type of adjectives used to describe older adults. We also analyzed responses to open-ended questions about changes in perception of older adults and aging and interest in working with older adults. Findings showed that: (1) Students’ attitudes improved following participation in the program; (2) students used fewer negative words to describe older adults following participation; (3) answers to open-ended questions demonstrated that many students improved their perceptions of older adults; and (4) many students showed increased interest in working with older adults in their future careers. Programs that reduce age stereotypes should be promoted in order to reduce young people’s harmful ageist stereotypes, ensure respectful treatment of older adults in all workplace and social situations, and increase interest in aging-related fields.
Smart City as a Tool of Citizen-Oriented Urban Regeneration: Framework of Preliminary Evaluation and Its Application
Authors: Oh Jooseok
Published: August 2020

This study explores projects to regenerate old urban spaces and introduce smart city systems. It focuses on citizen perspectives and ways to build a citizen-centered smart city. A survey of 624 residents was undertaken in three South Korean cities where relevant projects have been implemented. The Hierarchical Regression Model was employed to learn what factors affect citizens’ overall preferences for smart city projects. The analysis found that citizens prefer the services closely linked to their everyday lives, and that those with lower quality of life regarding housing circumstances and safety show greater interest in smart city projects, albeit there are differences among the cities. They also view and prefer those projects as a means of resolving everyday problems and local economic development, rather than seeking specific technologies or devices. Based on these results, this research presents implications and suggestions to link urban regeneration plans to smart city projects.
Social and Solidarity Economy in Ecuador: Fostering an Alternative Development Model?
Authors: Villalba-Eguiluz Unai , Arcos-Alonso Asier , Pérez de Mendiguren Juan Carlos , Urretabizkaia Leticia
Published: August 2020

The social and solidarity economy (SSE) has gained worldwide attention over the last decade. It represents a host of diverse economic activities which take different forms in each country, but which share solidarity values that are alternatives to mainstream market economic logics. In Ecuador, the SSE acquired legal status in the 2008 Constitution that aimed to foster an alternative development model based on the Buen Vivir (BV) paradigm. However, despite a broad new regulatory framework for the SSE, the implementation of specific policies faces significant challenges. This article, based on fieldwork and interviews with many stakeholders, critically analyzes the transformative scope of the policies of the main newly created institution (IEPS—Instituto de Economía Popular y Solidaria). We discuss policy challenges focusing on trade-offs for small rural producers due to their dependent market integration and overall flaws in fulfilling SSE solidarity values.
Renewable Energy Investment under Carbon Emission Regulations
Authors: Yuan Yuan , Cai Feng , Yang Lingling
Published: August 2020

This paper considers a risk-neutral energy supplier who operates an electricity plant in an uncertain demand market. To characterize the impact of carbon emission quota and emergency supply cost of coal electricity, we first consider four different cases, (1) traditional energy without carbon emission restriction; (2) traditional energy with carbon emission quota; (3) mixed energy (both traditional and renewable energy) without carbon emission restriction, and (4) mixed energy with carbon emission quota, to find the optimal renewable energy investment level and coal inventory mechanism for an energy supplier. Then, through the analysis we derive the resulting equilibriums: coal inventory for electricity generation and the investment of renewable energy capacity. By comparing the performances under different scenarios, we find that (a) renewable energy establishment can mitigate the depression of carbon emission constraint, (b) the energy supplier can obtain positive benefits from optimal mixed energy strategy if the additional emergency cost of traditional energy is not too high, and (c) the optimal renewable energy capacity level is decreasing in the carbon emission quota. Our numerical simulations imply that the impact of additional emergency cost to the profit difference between mixed energy strategy and traditional energy strategy is mediated by carbon emission quota.
Science-Driven Societal Transformation, Part I: Worldview
Authors: Boik John C.
Published: August 2020

Humanity faces serious social and environmental problems, including climate change and biodiversity loss. Increasingly, scientists, global policy experts, and the general public conclude that incremental approaches to reduce risk are insufficient and transformative change is needed across all sectors of society. However, the meaning of transformation is still unsettled in the literature, as is the proper role of science in fostering it. This paper is the first in a three-part series that adds to the discussion by proposing a novel science-driven research-and-development program aimed at societal transformation. More than a proposal, it offers a perspective and conceptual framework from which societal transformation might be approached. As part of this, it advances a formal mechanics with which to model and understand self-organizing societies of individuals. While acknowledging the necessity of reform to existing societal systems (e.g., governance, economic, and financial systems), the focus of the series is on transformation understood as systems change or systems migration—the de novo development of and migration to new societal systems. The series provides definitions, aims, reasoning, worldview, and a theory of change, and discusses fitness metrics and design principles for new systems. This first paper proposes a worldview, built using ideas from evolutionary biology, complex systems science, cognitive sciences, and information theory, which is intended to serve as the foundation for the R&D program. Subsequent papers in the series build on the worldview to address fitness metrics, system design, and other topics.
The Effect of a Non-Local Fractional Operator in an Asymmetrical Glucose-Insulin Regulatory System: Analysis, Synchronization and Electronic Implementation
Authors: Munoz-Pacheco Jesus M. , Posadas-Castillo Cornelio , Zambrano-Serrano Ernesto
Published: August 2020

For studying biological conditions with higher precision, the memory characteristics defined by the fractional-order versions of living dynamical systems have been pointed out as a meaningful approach. Therefore, we analyze the dynamics of a glucose-insulin regulatory system by applying a non-local fractional operator in order to represent the memory of the underlying system, and whose state-variables define the population densities of insulin, glucose, and β-cells, respectively. We focus mainly on four parameters that are associated with different disorders (type 1 and type 2 diabetes mellitus, hypoglycemia, and hyperinsulinemia) to determine their observation ranges as a relation to the fractional-order. Like many preceding works in biosystems, the resulting analysis showed chaotic behaviors related to the fractional-order and system parameters. Subsequently, we propose an active control scheme for forcing the chaotic regime (an illness) to follow a periodic oscillatory state, i.e., a disorder-free equilibrium. Finally, we also present the electronic realization of the fractional glucose-insulin regulatory model to prove the conceptual findings.
Motion Saliency Detection for Surveillance Systems Using Streaming Dynamic Mode Decomposition
Authors: Ngo Thien-Thu , Nguyen VanDung , Pham Xuan-Qui , Hossain Md-Alamgir , Huh Eui-Nam
Published: August 2020

Intelligent surveillance systems enable secured visibility features in the smart city era. One of the major models for pre-processing in intelligent surveillance systems is known as saliency detection, which provides facilities for multiple tasks such as object detection, object segmentation, video coding, image re-targeting, image-quality assessment, and image compression. Traditional models focus on improving detection accuracy at the cost of high complexity. However, these models are computationally expensive for real-world systems. To cope with this issue, we propose a fast-motion saliency method for surveillance systems under various background conditions. Our method is derived from streaming dynamic mode decomposition (s-DMD), which is a powerful tool in data science. First, DMD computes a set of modes in a streaming manner to derive spatial–temporal features, and a raw saliency map is generated from the sparse reconstruction process. Second, the final saliency map is refined using a difference-of-Gaussians filter in the frequency domain. The effectiveness of the proposed method is validated on a standard benchmark dataset. The experimental results show that the proposed method achieves competitive accuracy with lower complexity than state-of-the-art methods, which satisfies requirements in real-time applications.
On the Remarkable Superconductivity of FeSe and Its Close Cousins
Authors: Kreisel Andreas , Hirschfeld Peter , Andersen Brian
Published: August 2020

Emergent electronic phenomena in iron-based superconductors have been at the forefront of condensed matter physics for more than a decade. Much has been learned about the origins and intertwined roles of ordered phases, including nematicity, magnetism, and superconductivity, in this fascinating class of materials. In recent years, focus has been centered on the peculiar and highly unusual properties of FeSe and its close cousins. This family of materials has attracted considerable attention due to the discovery of unexpected superconducting gap structures, a wide range of superconducting critical temperatures, and evidence for nontrivial band topology, including associated spin-helical surface states and vortex-induced Majorana bound states. Here, we review superconductivity in iron chalcogenide superconductors, including bulk FeSe, doped bulk FeSe, FeTe1−xSex, intercalated FeSe materials, and monolayer FeSe and FeTe1−xSex on SrTiO3. We focus on the superconducting properties, including a survey of the relevant experimental studies, and a discussion of the different proposed theoretical pairing scenarios. In the last part of the paper, we review the growing recent evidence for nontrivial topological effects in FeSe-related materials, focusing again on interesting implications for superconductivity.
Use of Personal Care Products and Semen Quality: A Cross-Sectional Study in Young Danish Men
Authors: Ugelvig Petersen Kajsa , Balkiss Ahmad Mahmoud , Hærvig Katia Keglberg , Ellekilde Bonde Jens Peter , Hougaard Karin Sørig , Toft Gunnar , Ramlau-Hansen Cecilia Høst , Tøttenborg Sandra Søgaard
Published: August 2020

Personal care products (PCPs) may contain multiple chemicals capable of harming male reproductive function. The aim of this study was, therefore, to assess aggregated PCP exposure and potential associations with measures of semen quality in young men. Participants (n = 1058, age 18–21) were sampled among young men from the Danish National Birth Cohort (DNBC). Upon recruitment in 2017–2019, each man answered an online questionnaire and provided a semen sample. Exposure to 12 common types of PCPs was derived from the questionnaire, and the extent of use and co-use was analyzed. We applied a negative binomial regression model to estimate percentage differences in semen parameters between low, medium and high PCP exposure groups. All participants were exposed to at least one PCP more than once a week, resulting in a mean number (SD) of 5.3 (2.0) PCPs currently used. Most participants (92%) were also exposed to fragranced products on a weekly basis. Little association was observed between aggregated exposure to PCPs and sperm concentration, total sperm count, semen volume, sperm motility and morphology. Despite prevalent use of multiple PCPs, we found little indication of adverse effects of aggregated overall or fragranced PCP exposure on semen quality.
Primary Sequence and 3D Structure Prediction of the Plant Toxin Stenodactylin
Authors: Iglesias Rosario , Polito Letizia , Bortolotti Massimo , Pedrazzi Manuela , Citores Lucía , Ferreras José M. , Bolognesi Andrea
Published: August 2020

Stenodactylin is one of the most potent type 2 ribosome-inactivating proteins (RIPs); its high toxicity has been demonstrated in several models both in vitro and in vivo. Due to its peculiarities, stenodactylin could have several medical and biotechnological applications in neuroscience and cancer treatment. In this work, we report the complete amino acid sequence of stenodactylin and 3D structure prediction. The comparison between the primary sequence of stenodactylin and other RIPs allowed us to identify homologies/differences and the amino acids involved in RIP toxic activity. Stenodactylin RNA was isolated from plant caudex, reverse transcribed through PCR and the cDNA was amplificated and cloned into a plasmid vector and further analyzed by sequencing. Nucleotide sequence analysis showed that stenodactylin A and B chains contain 251 and 258 amino acids, respectively. The key amino acids of the active site described for ricin and most other RIPs are also conserved in the stenodactylin A chain. Stenodactylin amino acid sequence shows a high identity degree with volkensin (81.7% for A chain, 90.3% for B chain), whilst when compared with other type 2 RIPs the identity degree ranges from 27.7 to 33.0% for the A chain and from 42.1 to 47.7% for the B chain.
High Levels of Anabaenopeptins Detected in a Cyanobacteria Bloom from N.E. Spanish Sau-Susqueda-El Pasteral Reservoirs System by LC–HRMS
Authors: Flores Cintia , Caixach Josep
Published: August 2020

The appearance of a bloom of cyanobacteria in the Sau-Susqueda-El Pasteral system (River Ter, NE Spain) in the autumn of 2015 has been the most recent episode of extensive bloom detected in Catalonia. This system is devoted mainly to urban supply, regulation of the river, irrigation and production of hydroelectric energy. In fact, it is one of the main supply systems for the metropolitan area of cities such as Barcelona and Girona. An assessment and management plan was implemented in order to minimize the risk associated to cyanobacteria. The reservoir was confined and periodic sampling was carried out. Low and high toxicity was detected by cell bioassays with human cell lines. Additionally, analysis studies were performed by enzyme-linked immunosorbent assay (ELISA) and liquid chromatography–high resolution mass spectrometry (LC–HRMS). A microcystin target analysis and suspect screening of microcystins, nodularins, cylindrosperpmopsin and related cyanobacterial peptides by LC–HRMS were applied. The results for the analysis of microcystins were negative (<0.3 μg/L) in all the surface samples. Only traces of microcystin-LR, -RR and -dmRR were detected by LC–HRMS in a few ng/L from both fractions, aqueous and sestonic. In contrast, different anabaenopeptins and oscillamide Y at unusually high concentrations (µg-mg/L) were observed. To our knowledge, no previous studies have detected these bioactive peptides at such high levels. The reliable identification of these cyanobacterial peptides was achieved by HRMS. Although recently these peptides are detected frequently worldwide, these bioactive compounds have received little attention. Therefore, more studies on these substances are recommended, especially on their toxicity, health risk and presence in water resources.
Baculovirus Expression and Functional Analysis of Vpa2 Proteins from Bacillus thuringiensis
Authors: Simón Oihane , Palma Leopoldo , Fernández Ana , Williams Trevor , Caballero Primitivo
Published: August 2020

The mode of action underlying the insecticidal activity of the Bacillus thuringiensis (Bt) binary pesticidal protein Vpb/Vpa (formerly Vip1/Vip2) is uncertain. In this study, three recombinant baculoviruses were constructed using Bac-to-Bac technology to express Vpa2Ac1 and two novel Vpa2-like genes, Vpa2-like1 and Vpa2-like2, under the baculovirus p10 promoter in transfected Sf9 cells. Pairwise amino acid analyses revealed a higher percentage of identity and a lower number of gaps between Vpa2Ac1 and Vpa2-like2 than to Vpa2-like1. Moreover, Vpa2-like1 lacked the conserved Ser-Thr-Ser motif, involved in NAD binding, and the (F/Y)xx(Q/E)xE consensus sequence, characteristic of the ARTT toxin family involved in actin polymerization. Vpa2Ac1, Vpa2-like1 and Vpa2-like2 transcripts and proteins were detected in Sf9 culture cells, but the signals of Vpa2Ac1 and Vpa2-like2 were weak and decreased over time. Sf9 cells infected by a recombinant bacmid expressing Vpa2-like1 showed typical circular morphology and produced viral occlusion bodies (OBs) at the same level as the control virus. However, expression of Vpa2Ac1 and Vpa2-like2 induced cell polarization, similar to that produced by the microfilament-destabilizing agent cytochalasin D and OBs were not produced. The presence of filament disrupting agents, such as nicotinamide and nocodazole, during transfection prevented cell polarization and OB production was observed. We conclude that Vpa2Ac1 and Vpa2-like2 proteins likely possess ADP-ribosyltransferase activity that modulated actin polarization, whereas Vpa2-like1 is not a typical Vpa2 protein. Vpa2-like2 has now been designated Vpa2Ca1 (accession number AAO86513) by the Bacillus thuringiensis delta-endotoxin nomenclature committee.
Impact of Health Systems on the Implementation of Intermittent Preventive Treatment for Malaria in Pregnancy in Sub-Saharan Africa: A Narrative Synthesis
Authors: Olaleye Atinuke O. , Walker Oladapo
Published: August 2020

Malaria in pregnancy is a public health challenge with serious negative maternal and newborn consequences. Intermittent preventive treatment (IPTp) with sulphadoxine-pyrimethamine is recommended for the control of malaria during pregnancy within endemic areas, but coverage for the recommended ≥3 doses IPTp regimen has remained suboptimal. We searched PubMed, Cochrane library, and HINARI database from 1 January 2010 to 23 May 2020, for studies investigating the effect of the health system on IPTp implementation. Data extraction was independently performed by two investigators and evaluated for quality and content. Health system barriers and facilitators were explored using thematic analysis and narrative synthesis. Thirty-four out of 1032 screened articles were included. Key health system issues affecting the provision and uptake of IPTp were the ambiguity of policy and guidelines for IPTp administration, human resource shortages, drug stock-outs, conflicting policy implementation on free IPTp provision, hidden costs, unclear data recording and reporting guidelines, and poor quality of care. Factors affecting the supply and demand for IPTp services involve all pillars of the health system across different countries. The success of health programs such as IPTp will thus depend on how well the different pillars of the health system are articulated towards the success of each program.
Resonant Ultrarelativistic Electron–Positron Pair Production by High-Energy Electrons in the Field of an X-ray Pulsar
Authors: Sizykh Georgii K. , Roshchupkin Sergei P. , Dubov Victor V.
Published: August 2020

The process of resonant high-energy electron–positron pair production by an ultrarelativistic electron colliding with the field of an X-ray pulsar is theoretically investigated. Resonant kinematics of the process is studied in detail. Under the resonance condition, the intermediate virtual photon in the X-ray pulsar field becomes a real particle. As a result, the initial process of the second order in the fine structure constant effectively reduces into two successive processes of the first order: X-ray-stimulated Compton effect and X-ray-stimulated Breit–Wheeler process. For a high-energy initial electron all the final ultrarelativistic particles propagate in a narrow cone along the direction of the initial electron momentum. The presence of threshold energy for the initial electron which is of order of 100 MeV for 1-KeV-frequency field is shown. At the same time, the energy spectrum of the final particles (two electrons and a positron) highly depends on their exit angles and on the initial electron energy. This result significantly distinguishes the resonant process from the non-resonant one. It is shown that the resonant differential probability significantly exceeds the non-resonant one.
Urban Commute Travel Distances in Tehran, Istanbul, and Cairo: Weighted Least Square Models
Authors: Masoumi Houshmand
Published: August 2020

A very large part of the literature on urban commute travels is related to high-income countries. The determinants of urban commute trip distances are not clear in the Middle East and North Africa (MENA); thus, this study attempts to shed light on this topic in relation to Tehran, Istanbul, and Cairo. The objective is to clarify which environmental and human factors are correlated with commuting distance in these cities. Using primary disaggregate data produced by surveys in the three cities (n = 8237) in 2017, weighted least square regressions showed that fifteen significant or highly significant variables, including individual and household characteristics, mobility decisions, residential location, and land use attributes, predict the lengths of urban commute trips in the MENA sample. Unlike western countries, age and gender are not significant predictors of commute distance in MENA large cities. The results of independent-sample Kruskal–Wallis test show that there is a significant difference between the mean one-way commute travel distances in the three cities (Tehran: 9096 m, Istanbul: 10839 m, and Cairo: 6670 m); however, there are some similarities in the determinants of commute distance in the three cities. The results can be adopted to reduce commute trip lengths by providing a more connected street network and accessible neighborhood-level facilities.
Viral Vectors Applied for RNAi-Based Antiviral Therapy
Authors: Lundstrom Kenneth
Published: August 2020

RNA interference (RNAi) provides the means for alternative antiviral therapy. Delivery of RNAi in the form of short interfering RNA (siRNA), short hairpin RNA (shRNA) and micro-RNA (miRNA) have demonstrated efficacy in gene silencing for therapeutic applications against viral diseases. Bioinformatics has played an important role in the design of efficient RNAi sequences targeting various pathogenic viruses. However, stability and delivery of RNAi molecules have presented serious obstacles for reaching therapeutic efficacy. For this reason, RNA modifications and formulation of nanoparticles have proven useful for non-viral delivery of RNAi molecules. On the other hand, utilization of viral vectors and particularly self-replicating RNA virus vectors can be considered as an attractive alternative. In this review, examples of antiviral therapy applying RNAi-based approaches in various animal models will be described. Due to the current coronavirus pandemic, a special emphasis will be dedicated to targeting Coronavirus Disease-19 (COVID-19).
Peste des petits ruminants Virus Transmission Scaling and Husbandry Practices That Contribute to Increased Transmission Risk: An Investigation among Sheep, Goats, and Cattle in Northern Tanzania
Authors: Herzog Catherine M. , de Glanville William A. , Willett Brian J. , Cattadori Isabella M. , Kapur Vivek , Hudson Peter J. , Buza Joram , Swai Emmanuel S. , Cleaveland Sarah , Bjørnstad Ottar N.
Published: August 2020

Peste des petits ruminants virus (PPRV) causes an infectious disease of high morbidity and mortality among sheep and goats which impacts millions of livestock keepers globally. PPRV transmission risk varies by production system, but a deeper understanding of how transmission scales in these systems and which husbandry practices impact risk is needed. To investigate transmission scaling and husbandry practice-associated risk, this study combined 395 household questionnaires with over 7115 cross-sectional serosurvey samples collected in Tanzania among agropastoral and pastoral households managing sheep, goats, or cattle (most managed all three, n = 284, 71.9%). Although self-reported compound-level herd size was significantly larger in pastoral than agropastoral households, the data show no evidence that household herd force of infection (FOI, per capita infection rate of susceptible hosts) increased with herd size. Seroprevalence and FOI patterns observed at the sub-village level showed significant spatial variation in FOI. Univariate analyses showed that household herd FOI was significantly higher when households reported seasonal grazing camp attendance, cattle or goat introduction to the compound, death, sale, or giving away of animals in the past 12 months, when cattle were grazed separately from sheep and goats, and when the household also managed dogs or donkeys. Multivariable analyses revealed that species, production system type, and goat or sheep introduction or seasonal grazing camp attendance, cattle or goat death or sales, or goats given away in the past 12 months significantly increased odds of seroconversion, whereas managing pigs or cattle attending seasonal grazing camps had significantly lower odds of seroconversion. Further research should investigate specific husbandry practices across production systems in other countries and in systems that include additional atypical host species to broaden understanding of PPRV transmission.
Plant-Derived Nutraceuticals and Immune System Modulation: An Evidence-Based Overview
Authors: Di Sotto Antonella , Vitalone Annabella , Di Giacomo Silvia
Published: August 2020

Immunomodulators are agents able to affect the immune system, by boosting the immune defences to improve the body reaction against infectious or exogenous injuries, or suppressing the abnormal immune response occurring in immune disorders. Moreover, immunoadjuvants can support immune system acting on nonimmune targets, thus improving the immune response. The modulation of inflammatory pathways and microbiome can also contribute to control the immune function. Some plant-based nutraceuticals have been studied as possible immunomodulating agents due to their multiple and pleiotropic effects. Being usually more tolerable than pharmacological treatments, their adjuvant contribution is approached as a desirable nutraceutical strategy. In the present review, the up to date knowledge about the immunomodulating properties of polysaccharides, fatty acids and labdane diterpenes have been analyzed, in order to give scientific basic and clinical evidence to support their practical use. Since promising evidence in preclinical studies, limited and sometimes confusing results have been highlighted in clinical trials, likely due to low methodological quality and lacking standardization. More investigations of high quality and specificity are required to describe in depth the usefulness of these plant-derived nutraceuticals in the immune system modulation, for health promoting and disease preventing purposes.
Effectiveness and Impact of the 4CMenB Vaccine against Group B Meningococcal Disease in Two Italian Regions Using Different Vaccination Schedules: A Five-Year Retrospective Observational Study (2014–2018)
Authors: Azzari Chiara , Moriondo Maria , Nieddu Francesco , Guarnieri Valentina , Lodi Lorenzo , Canessa Clementina , Indolfi Giuseppe , Giovannini Mattia , Napoletano Giuseppina , Russo Francesca , Baldovin Tatjana , Cocchio Silvia , Ricci Silvia , Baldo Vincenzo
Published: August 2020

Background: A few years after the introduction in Italy of a four-component anti-meningococcal B vaccine (4CMenB), we evaluated the effectiveness and impact of vaccination in two regions using different schedules (2, 4, 6, 12 months in Tuscany vs. 7, 9, 15 months in Veneto) through an observational retrospective study. Methods: Vaccination started in 2014 in Tuscany and in 2015 in Veneto; the data collected referred to the period 2006–2018 for Tuscany and 2007–2018 for Veneto. Cases of invasive meningococcal disease due to N. Meningitidis B were identified by culture and/or real-time PCR. Results: In Tuscany, pre-vaccine incidence was 1.96 (95% CL 1.52; 2.40) and dropped to 0.62 (95% CL 0.60; 0.64) in the post-4CMenB era. Evaluating only vaccinated children, post-4CMenB incidence was 0.12 (95% CL 0.08; 0.15). In Veneto pre-vaccine incidence was 1.94 (95% CL 1.92; 1.96) and dropped to 1.34 (95% CL 1.31; 1.38) in the post-4CMenB era. In the vaccinated population, MenB incidence was 0.53 (95% CL 0.50; 0.56). Vaccine effectiveness was 93.6% (95% CL 55.4; 99.1) in Tuscany and 91.0% (95% CL 59.9; 97.9) in Veneto, with mean vaccine coverages of 83.9% and 81.7%, respectively. The overall impact (evaluating both vaccinated and unvaccinated children) was 0.68 (95% CL 0.10; 0.89) in Tuscany and 0.31 (95% CL −0.56; 0.69) in Veneto; the total impact (evaluating only vaccinated children) was 0.94 (95% CL 0.56; 0.99) and 0.90 (95% CL 0.57; 0.97), respectively. The relative case reduction (RCR) was 65% in Tuscany and 31% in Veneto. Considering the vaccinated population, the RCR was equal to 91% and 80%, respectively. Conclusion: In conclusion, 4CMenB appears to have a very high effectiveness in Italy; the impact of vaccination appears greater where the immunization program is started early.
A Replicating Single-Cycle Adenovirus Vaccine Effective against Clostridium difficile
Authors: Matchett William E. , Anguiano-Zarate Stephanie , Malewana Goda Baddage Rakitha , Mudrick Haley , Weldy Melissa , Evert Clayton , Khoruts Alexander , Sadowsky Michael , Barry Michael A.
Published: August 2020

Clostridium difficile causes nearly 500,000 infections and nearly 30,000 deaths each year in the U.S., which is estimated to cost $4.8 billion. C. difficile infection (CDI) arises from bacteria colonizing the large intestine and releasing two toxins, toxin A (TcdA) and toxin B (TcdB). Generating humoral immunity against C. difficile’s toxins provides protection against primary infection and recurrence. Thus, a vaccine may offer the best opportunity for sustained, long-term protection. We developed a novel single-cycle adenovirus (SC-Ad) vaccine against C. difficile expressing the receptor-binding domains from TcdA and TcdB. The single immunization of mice generated sustained toxin-binding antibody responses and protected them from lethal toxin challenge for up to 38 weeks. Immunized Syrian hamsters produced significant toxin-neutralizing antibodies that increased over 36 weeks. Single intramuscular immunization provided complete protection against lethal BI/NAP1/027 spore challenge 45 weeks later. These data suggest that this replicating vaccine may prove useful against CDI in humans.
Water Supply and Water Scarcity
Authors: Tzanakakis Vasileios A. , Paranychianakis Nikolaos V. , Angelakis Andreas N.
Published: August 2020

This paper provides an overview of the Special Issue on water supply and water scarcity. The papers selected for publication include review papers on water history, on water management issues under water scarcity regimes, on rainwater harvesting, on water quality and degradation, and on climatic variability impacts on water resources. Overall, the issue underscores the need for a revised water management, especially in areas with demographic change and climate vulnerability towards sustainable and secure water supply. Moreover, general guidelines and possible solutions, such as the adoption of advanced technological solutions and practices that improve water use efficiency and the use of alternative (non-conventional) water resources are highlighted and discussed to address growing environmental and health issues and to reduce the emerging conflicts among water users.
Impacts of the Degraded Alpine Swamp Meadow on Tensile Strength of Riverbank: A Case Study of the Upper Yellow River
Authors: Zhu Haili , Gao Peng , Li Zhiwei , Fu Jiangtao , Li Guorong , Liu Yabin , Li Xilai , Hu Xiasong
Published: August 2020

In the meandering riverbank of the Upper Yellow River (UYR), the native alpine swamp meadow (AS) has continuously degenerated into an alpine meadow (AM) due to climate change and intensified grazing. Its implication on river morphology is still not well known. This study examined this effect by in situ measurings of (1) physical properties of roots and their distribution in the soil-root mixture of the upper bank layer, and (2) the tensile strength in terms of excavating tests for triggering cantilever collapses of AS and AM riverbanks. The results showed that the root number in AS was significantly greater than that in AM, though the root distribution in both was similar. Also, the average tensile strength of individual roots in AS was 31,310 kPa, while that in AM was only 16,155 kPa. For the soil-root mixture, it decreased from 67.39 to 21.96 kPa. The weakened mechanical property was mainly ascribed to the lessened root number and the simpler root structure in the soil-root mixture of AM that reduces its ability to resist the external force. These findings confirmed that healthy AS can enhance bank stability and delay the development of tensile cracks in the riverbank of the meandering rivers in the UYR.
Characteristics of the Biochemical Composition and Bioavailability of Phytoplankton-Derived Particulate Organic Matter in the Chukchi Sea, Arctic
Authors: Kim Bo , Jung Jinyoung , Lee Youngju , Cho Kyoung-Ho , Gal Jong-Ku , Kang Sung-Ho , Ha Sun-Yong
Published: August 2020

Analysis of the biochemical composition (carbohydrates, CHO; proteins, PRT; lipids, LIP) of particulate organic matter (POM, mainly phytoplankton) is used to assess trophic states, and the quantity of food material is generally assessed to determine bioavailability; however, bioavailability is reduced or changed by enzymatic hydrolysis. Here, we investigated the current trophic state and bioavailability of phytoplankton in the Chukchi Sea (including the Chukchi Borderland) during the summer of 2017. Based on a cluster analysis, our 12 stations were divided into three groups: the southern, middle, and northern parts of the Chukchi Sea. A principal component analysis (PCA) revealed that relatively nutrient-rich and high-temperature waters in the southern part of the Chukchi Sea enhanced the microphytoplankton biomass, while picophytoplankton were linked to a high contribution of meltwater derived from sea ice melting in the northern part of the sea. The total PRT accounted for 41.8% (±7.5%) of the POM in the southern part of the sea, and this contribution was higher than those in the middle (26.5 ± 7.5%) and northern (26.5 ± 10.6%) parts, whereas the CHO accounted for more than half of the total POM in the northern parts. As determined by enzymatic hydrolysis, LIP were more rapidly mineralized in the southern part of the Chukchi Sea, whereas CHO were largely used as source of energy for higher trophic levels in the northern part of the Chukchi Sea. Specifically, the bioavailable fraction of POM in the northern part of the Chukchi Sea was higher than it was in the other parts. The findings indicate that increasing meltwater and a low nutrient supply lead to smaller cell sizes of phytoplankton and their taxa (flagellate and green algae) with more CHO and a negative effect on the total concentration of POM. However, in terms of bioavailability (food utilization), which determines the rate at which digested food is used by consumers, potentially available food could have positive effects on ecosystem functioning.
Dynamic Evaluation and Internal Driving Factors of Water Resources Green Efficiency in China
Authors: Zhang Hongbo , Chen Hong , Wu Meifen , Jin Wei , Mao Guangxiong , Long Ruyin
Published: August 2020

High-quality economic development and the realization of ecological civilization have become the main goals of China’s economic development. This study constructed a global reference Malmquist–Luenberger productivity index model of directional distance function from the perspective of mixed disposability and divided water resources green efficiency into pure technical efficiency change (PEC) index, scale efficiency change (SEC) index, pure technology change (PTC) index and scale technology change (STC) index. The results show the following: (1) The value of China’s water resources green efficiency increased by 1.1% from 2000 to 2016. The central region improved the most (1.4%), followed by the western (1%) and eastern (0.9%) regions. The water resources green efficiency improved in all provinces except Guangxi and Yunnan. (2) The water resources green efficiency is significantly affected by national policies, and there may not be a significant positive correlation with economic development. At present, the water resources green efficiency in most provinces still needs to be improved. (3) From 2000 to 2016, China’s water resources green efficiency decomposition index showed an upward trend except for SEC, and PTC was the main driving force for improving China’s water resources green efficiency. (4) The variation of PEC among provinces showed an inverted “N” trend, while the differences of SEC and STC showed an ascending trend, and PTC showed an inverted “U” trend. The proportions of provinces in which PEC, SEC, and STC indices improved were 40%, 46.67%, and 60%, respectively.