bluuebunny/crossref_metadata_2025 huggingface dataset:
THERMAL INSULATION OF BUILDINGS USING INNOVATIVE MATERIALS BASED ON NANOPARTICLES
Authors:   NIRD URBAN-INCERC Cluj-Napoca Branch, 117 Calea Florești, 400524 Cluj-Napoca, Romania, TOADER Tudor Panfil , DICO Carmen ,   NIRD URBAN-INCERC Cluj-Napoca Branch, 117 Calea Florești, 400524 Cluj-Napoca, Romania, MIRCEA Anamaria Cătălina ,   NIRD URBAN-INCERC Cluj-Napoca Branch, 117 Calea Florești, 400524 Cluj-Napoca, Romania
Published: April 2024

Nano Insulation is a liquid-consistency, colourable, paint-like thermal insulation material with many other beneficial properties in addition to insulation. It is a material that can be used both indoors and outdoors in industrial, civil and other types of constructions. Compared to conventional insulation materials, this photocatalytic system is beneficial for internal and external air purification and uses nanotechnology with Titanium Dioxide effective for preventing viruses, bacteria, cleaning polluted air from toxins, removing odours, stopping moulds and fungi, purifying water and more benefits. Among the essential features we list: Heat reflection by at least 60-70%, which reduces heat costs by at least 30%; Reduces the noise level by 0.6 mm up to 2 dB; its composition does not contain harmful or poisonous components; protects the coated surface against weather conditions and corrosion; retains its properties in extreme conditions for a long time; it has a lifespan of over 10 years; with implementation guarantee; with a side cover, the quality of incoming cold air is reduced by at least 30%, with both sides covered by at least 55%; 78% water absorption and high vapour permeability are excellent for the interior comfort; is non-combustible: does not fuel the combustion, helps to slow down the speed of the flame; simple and quick use with a sprayer.
Secure data-out API - enabling encrypted htsget transactions
Authors: Bampalikis Dimitrios , Koumpoouras Konstantinos , Negru Stefan , Viklund Johan
Published: April 2024

The European Genome-phenome Archive (EGA) is a service for archiving and sharing personally identifiable genetic and phenotypic data, while the The Genomic Data Infrastructure (GDI) project is enabling access to genomic and related phenotypic and clinical data across Europe. Both projects are focused on creating federated and secure infrastructure for researchers to archive and share data with the research community, to support further research.This project proposal is focusing on the data access part of the infrastructure. The files are encrypted in the archives, using the crypt4gh standard. Currently, there exist data access processes, where the files are either decrypted on the server side and then transferred to the user or re-encrypted server-side and provided to the user in an outbox.Htsget as a data access protocol also allows access to parts of files, but there’s currently no production-level client tools that support access to encrypted data. Our goal is to create a client tool that can access encrypted data over the htsget protocol. It should also work with the GA4GH Passport and Visa standard so we can then enhance the security of our data access interfaces. We will also modify htsget-rs, a Rust htsget server, and crypt4gh-rust as required to support the aforementioned standards. Finally, there will be an effort to implement this feature in already existing tools, like samtools and IGV.
THE ACTIVITIES OF INSURANCE COMPANIES UNDER MARTIAL LAW AND THEIR ROLE IN THE POST-WAR RECOVERY OF UKRAINE
Authors: MARTSENIUK Olena , Ruda Oksana
Published: April 2024

The article analyzes the current state of activity of insurance companies, which is formed under the influence of crisis trends of recent years: the Covid-19 pandemic and quarantine restrictions, a full-scale invasion of the russian federation and mass damage. The extent of the damage to the Ukraine’s economy and the needs for recovery have been analyzed, which will include special support and mobilization of the private sector, as well as necessary costs for the recovery of housing, social infrastructure, energy and transport.

It is noted that the downward changes in the number of companies do not have a negative impact on the quality of services provided and the penetration of the insurance market, as these trends may indicate changes in the insurance market and its adaptation to new conditions, reflecting the impact of changes in the economy as a whole, the regulatory environment and demand for specific types of insurance products.

It has been determined that in the future, the number of lawsuits under military policies from the ships damaged by sea mines, missile attacks and bombings in the conflict zone in the Black and Azov seas, as well as under private contracts, will increase in the activity of insurance companies. The structural changes in the insurance market and the factors that caused them are analyzed, as well as the trends of changes are given.

It has been proven that in the conditions of martial law, the issue of war risk insurance possibilities is quite natural. The possibilities of introducing a fully functional military risk insurance system in Ukraine, which is provided for by the Memorandum on Economic and Financial Policy between Ukraine and the IMF, have been studied. This concept was developed with the participation of specialists from the World Bank, the National Bank of Ukraine of Ministry of Finance and the Ministry of Economy of Ukraine, which is positive for the progressive development of the insurance market of our country in the direction of adaptation to EU standards.

A comprehensive analysis of the insurance products of the leading Ukrainian insurers, which provide protection against war risks, was carried out. Prospects for the introduction of new insurance products that will meet the needs of society have been determined.

The most promising is the implementation of the effective measures for the proper insurance of investments against war risks, which can contribute to the attraction of funds for the reconstruction of the country, the relocation of enterprises, the organization of high-tech production and services, the creation of new jobs, the adoption and application of innovative experience, an increase in the level of income and an increase in income to state.
The Festival City in Event Management Research
Authors: Todd Louise , Quinn Bernadette
Published: April 2024

This curated collection considers the topic of the Festival City and examines how research on this theme published in the Event Management journal has contributed to extant theory in event management and event studies. Our article examines the evolution of the Festival City concept
over the last 25 years. First, we introduce the Festival City in theoretical and practical terms. We then explore related concepts, most notably the Eventful City, which is the most prominent theme in the existing research. Our commentary continues by exploring how the research has conceptualized
the Festival City, major themes emerging from the research, and contributions to theory development. We reflect on the limitations of the present research and conclude by suggesting future research directions for the Festival City concept in Event Management.
METHOD OF EXPERIMENTAL RESEARCH OF OIL CONTAINING WASTE WITH INCREASED RADIOACTIVITY AS AN OBJECT OF ECOLOGICAL RISK
Authors:   Samara Federal Research Center of Russian Academy of Science, Vasilyev A.V. , Ermakov V.V. ,   Samara Federal Research Center of Russian Academy of Science, Shcherbakov D.E. ,   Samara Federal Research Center of Russian Academy of Science
Published: April 2024

In this paper the problems of negative impact of oil-containing waste with increased radioactivity to biosphere are considered. Review of the sources of increased radioactivity of oil-containing waste as a factor of negative impact to biosphere is carried out. Method of carrying out of experiment for determination of specific effective activity of natural radioactive nuclides is described. Suggested method is allowing us to establish the nature of the distribution of natural radioactive nuclides of oil-containing waste, to determine the coefficients of migration of radioactive nuclides and it dependence from the characteristic of oil-containing waste. Results of work are allowing us to carry out more efficient and high quality reduction of negative impact of oil-containing waste to the biosphere and to take timely and qualitative measures to reduce radioactive nuclides negative impact in oil-containing sludges as a factor of ecological risk.
CORRECTIVE ACTION PROCESS MATURITY MODEL
Authors:   Saint Petersburg Electrotechnical University ", Prelovskaya O.G. ,   LETI"
Published: April 2024

The purpose of this paper is to present the model for assessing Corrective action process maturity level. The model is developed as a tool for evaluating and managing the process of corrective actions, which is considered as one of the key elements of Quality Management System within International Standard ISO 9001:2015, and also the process represents a specific requirement in problem-solving in many industry standards (for example, IATF 16949:2016, ISO/TS 22163:2017, AS/EN 9100:2016). The model is developed based on the survey results of manufacturing companies’ employees competent in problem-solving (N = 259). Structural Equation Modeling in STATA program was used to analyze the results. Verified factors significantly affecting Corrective actions and problem-solving process are integrated into the model. Obtained results are analyzed by means of fuzzy logic algorithm in MATLAB, that enables process maturity level assessment in accordance with recommendations of ISO/IEC 330XX series of standards.
PECULIARITIES OF CORPORATE MANAGEMENT OF INNOVATIVE DEVELOPMENT IN INTERNATIONAL COMPANIES
Authors: Bahlei Rostyslav
Published: April 2024

Purpose. The article is aimed at identifying the main patterns of corporate governance in international companies at the present stage in the context of globalisation of the world economy.

Methodology of research. The following methods were used in the study to achieve this goal: methods of system analysis (for analyzing problems in planning innovations in companies); theory of strategic management, theory of categories (to describe methods and techniques of corporate governance in international companies); scientific abstraction, deduction and induction (to formulate a scientific hypothesis of work, laws and principles); abstract and logical (to make theoretical generalizations, substantiate the research methodology, formulate conclusions); monographic (for detailed analysis of the results of the study).

Findings. The theoretical, organisational and practical foundations of innovative development in international corporations are considered. It is established that today a number of issues related to the effectiveness of the management system in corporations are being modernised and revised due to the active transition to digitalisation. The vector of innovative development as the main format of managerial thinking of corporate managers in the context of digitalisation is updated. The market capitalisation of the world’s largest Internet companies is analysed. The sequence of stages (phases) of digital transformation of the business model of international corporations is considered.

Originality. The instruments of corporate innovation of international companies have been further developed. The directions of application of innovative tools in creating an effective strategy for the company’s innovative development are determined.

Practical value. The outlined proposals on the directions of development of the processes of innovative development of international companies can be used to improve the efficiency of their activities.

Key words: analysis, planning, strategic management, international business, innovation, innovation process, corporate governance.
La interseccionalidad como marco para la construcción de políticas públicas orientadas a las personas trans
Authors: Mora Barrera Gerardo de Francisco , Ramón Rodríguez Mónica
Published: April 2024

This article aims to demonstrate that the concept of intersectionality is a fundamental analytical input for the construction of public policies aimed at trans people. Through a conceptual analysis, this work argues that intersectionality contributes to a clear understanding of different types of violence that are reproduced through institutional mechanisms and, consequently, demonstrates how intersectionality can also be an analytical mechanism to build public policies that prevent medicalization-pathologization of trans bodies, the marginalization of certain communities and sexual classification for the assignment of social roles and opportunities
Assessment of Measurable Residual Disease on Day 28 of First Induction Chemotherapy in Acute Myeloid Leukaemia Patients
Authors: Akhter Nasrin , Chowdhury Raiq Raihan , Kabir Md. Maruf Reza , Rajib Sorowar Jahan , Dey Mily , Nasrin Papri , Poddar Sharup Chandra , Islam Ismat Ara , Rahman Aminur , Shah Md. Salahuddin
Published: April 2024

Background: Measurable residual disease (MRD) is an independent, strong, prognostic marker in acute myeloid leukaemia (AML) that is important for risk stratification and treatment planning. This study assessed the MRD on day-28 after first induction chemotherapy in AML patients. Objective: To assess measurable residual disease status on day 28 after the first induction chemotherapy in newly diagnosed acute myeloid leukaemia patients. Methodology: This cross-sectional study was conducted at the Department of Haematology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka from April 2021 to March 2022 among a total of 25 newly diagnosed AML patients who were admitted and received induction chemotherapy with DA (7+3). On Day-28, bone marrow aspiration was done with standard procedure and first pull of 2ml bone marrow sample was sent to a laboratory for MRD evaluation by multiparameter flow cytometry. MRD was considered positive when value was ?0.1%. Results: On day 28 of post induction chemotherapy most of the patients (92%) achieved morphological remission and among them more than half (52.2%) were MRD positive. The presence of CD14 myeloid marker and baseline higher serum uric acid level was significant in MRD positive patients and cytarabine dose 150 mg/m2 was found significant in MRD negative patients. Conclusion: More than half of the Acute Myeloid Leukaemia patients, treated with standard induction chemotherapy and achieved morphological remission on day 28 of chemotherapy, had positive measurable residual disease assessed by multiparameter flow cytometry. Positive MRD indicates relatively poorer prognosis and may necessitate more cycles of induction followed by more intensive consolidation which may include haematopoietic stem cell transplantation.
Role of Neutrophil-Lymphocyte Ratio in Predicting Severity of COVID-19
Authors: Rajib Md. Saroar Jahan , Chowdhury Md. Raiq Raihan , Reza Md. Samim , Dey Mily , Akhter Nasrin , Kabir Md. Maruf Reza , Hossain Md. Mosharaf , Khandakar Md. Abdul Bari , Shah Md. Salahuddin
Published: April 2024

Background: Higher neutrophil-lymphocyte ratio (NLR) is considered as cardinal findings with prognostic potentials in identification of severe COVID-19 cases. However, whether baseline NLR could be a predictor of disease severity and outcome remained to be investigated. Hence, this study was conducted with an aim to evaluate the relation of NLR (on admission) with disease severity. Objective: The objective of the study was to estimate the neutrophil-lymphocyte ratio among COVID-19 patients and its role in predicting disease severity. Method: This cross-sectional study was conducted in Bangabandhu Sheikh Mujib Medical University (BSMMU) from July 2020 to June 2021. Ninety-four COVID-19 admitted patients were enrolled following inclusion & exclusion criteria. Informed consent was taken from the subjects. Ethical clearance was obtained from institutional review board (IRB) of BSMMU. Complete blood count for N-L ratio was done by standard procedure on admission by SYSMEX XN-2000 haematology analyser. Clinical and laboratory information were recorded with a semi-structured questionnaire. After collection of all the required data, analysis was done by SPSS 24.0. Results: Mean age of the patients was 56.59±12.25 years, wherein maximum patients were male (67%), non-smoker (80.9%), and retired/current service holder (51.1%). Maximum patients were hypertensive (61.7%) and diabetic (56.4%). Besides, maximum study patients (64.9%) were in severe category of COVID-19, followed by moderate (20.2%) and mild (14.9%) category according to National Guidelines on Clinical Management of COVID-19 criteria. Mean NLR was 5.40±4.35 (SD), wherein on admission NLR was significantly higher among severe COVID-19 patients compared to mild/moderate category (6.90±4.64 vs 2.61±1.53, p <0.05). 28-days hospital mortality was found to be significantly associated with NLR (p<0.05). Receiver operator curve analysis found highly significant cut-off value for NLR (3.42) with 75.4% sensitivity and 75.8% specificity in predicting severe COVID-19 patients (AUC= 0.841, p value <0.001). Multivariate logistic regression analysis found NLR as an independent predictor for severe COVID-19 (OR=4.68, 95% CI: 1.29-16.81, P=0.019). Pearson correlation analysis showed that NLR had significant positive correlation with CRP and D-dimer as p value <0.05. Conclusion: NLR can predict the disease severity and outcome of hospitalized COVID-19 patients. However, further larger study is recommended.
Psikologlar ve Psikolojik Danışmanlar için Psikofarmakolojiye Giriş
Authors: Özen Yener
Published: April 2024

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Chemoenzymatic synthesis of macrocyclic peptides and polyketides via thioesterase-catalyzed macrocyclization
Authors: Qiao Senze , Cheng Zhongyu , Li Fuzhuo
Published: April 2024

Chemoenzymatic strategies that combine synthetic and enzymatic transformations offer efficient approaches to yield target molecules, which have been increasingly employed in the synthesis of bioactive natural products. In the biosynthesis of macrocyclic nonribosomal peptides, polyketides, and their hybrids, thioesterase (TE) domains play a significant role in late-stage macrocyclization. These domains can accept mimics of native substrates in vitro and exhibit potential for use in total synthesis. This review summarizes the recent advances of TE domains in the chemoenzymatic synthesis for these natural products that aim to address the common issues in classical synthetic approaches and increase synthetic efficiencies, which have the potential to facilitate further pharmaceutical research.
Antigone's Gaze
Authors: Aronson O. V.,
Published: April 2024

The article is devoted to the work of Russian philosopher and cultural researcher Helen Petrovsky. The focus of the article is her original way of working, which consists in expanding the possibilities of philosophical analysis through reference to the practice of contemporary arts. Where art reveals its technique, Helen Petrovsky sees an opportunity to find a mechanism corresponding to this method in the sphere of thinking, a version of the Kantian Witz. The example of Helen Petrovsky's analysis of painting and photography shows that her attention is focused on signs-affects, stains, traces, imprints of the external (nature or society), which are in conflict with human abilities of perception and understanding. Here the side of the image that remains outside the representation manifests itself. Turning to Lacoue-Labarthe's mimetology and Mondzain's interpretation of the icon allows us to see more clearly the Russian scholar's original way of working. Her critical gaze reanimates the "logic of the tragic" (Lacoue-Labarthe) as the culturally displaced basis of cognition (Oedipus' line) and judgment (Antigone's line). The collective affectivity and modern technologies with which Helen Petrovsky works allow us today to see Greek tragedy not so much as a cultural value, but as an alternative practice of thinking immanent to the problems of contemporary society.
Community as a metaphor for modernity
Authors: Neretina
Published: April 2024

The article is about the revision, in connection with the crisis, primarily of the communist idea in the twentieth century. stable concepts, such as, for example, community (understood not as a social, institutionally realized form of collectivity, but as an intellectual form, as “an unorganized force, an intense feeling of participation in something), an image (which is not a subjective representation in the mind an absent object, but passive, deprived of a creative authority, mobile in relation to the figures reproduced in them, deprived of the status of a subject or object), individuality, singularity, etc. A methodological question is raised about ways of collecting and thinking through the world, dependent on time and independent of it, in particular, about the meaning of repetition. The role of H. Petrovsky in developing the theme of non-working, indescribable communities and the understanding of freedom, art, ethics, etc. associated with this theme is emphasized.
Riddles of Bibikhin
Authors: Akhutin A. V.,
Published: April 2024

The philosophical disposition of the mind of Vladimir Bibikhin is deeply related to the thought of Martin Heidegger, but at the same time his existential character is almost directly opposite. What is common to them is the understanding of thought as the docile attention to the event of being. The text outlines three aspects of this disposition of mind, which all are disputed by the author. (1) Consciousness is not only the Carthesian ruler, but also the subject of the ethical reflexion, conscience. (2) In the “seizedness” as the basic frame of mind of the docile attention the turn of the possessedness is concealed. (3) In the political turn of the seizing historical event the totalitarian power is hidden.
Doubting trauma. What does philosophical inquiry of this notion mean?
Authors: Murzin
Published: April 2024

The philosophical study of trauma involves considering this concept in a circle of apparently abstract examples, commenting on it from the perspectives of ontology, metaphysics, aesthetics, and ethics. The difficulty with trauma is not simply that it stands as a subject for disciplines of a different kind and intentionality, but that it is inherently bound to resist all theoretical reasoning at all. This notion is not so much contradictory as actively negative in relation to the usual application of theoretical apparatus to it and its like. But the further one deals with trauma, even if one is not a metaphysician, even if one is at its mercy, the more clearly one realizes that thought cannot deny itself for the sake of earthly pain, no matter how much it may feel the urge to accomplish this self-overcoming, that it will remain itself even in the analysis of trauma, i. e., a movement from fact to essence. And accordingly, the trauma will be abstracted and revealed from paradoxical and formal sides, in its otherness and ambiguity.
A novel approach to interpreting Aristotle
within the framework of Alexey Chernyakov's scholarly investigation
Authors: Gushchin O.V.,
Published: April 2024

The distinctive feature of Aristotle's philosophical discourse lies in its subtle transition, at a particular juncture, from metaphysical to ontological discourse. The proactive restoration of the original metaphysical framework pertaining to specific concepts facilitates the identification of the precise location or moment at which their spontaneous reinterpretation transpires. The recognition of the threshold of semantic "recalculation," employed as a hermeneutic procedure, constitutes a novel methodological approach to the analysis of Aristotle's works. In accordance with this approach, it is imperative to regard the concepts and categories within Aristotelian philosophy, particularly those authored by Aristotle himself, not merely as representations of meanings unfolding within the primary text (a methodology not applicable in Aristotle's case), but rather as autonomous metatexts. The interpretation of these metatexts may initially appear as a thematically abstract exercise. Engaging with metatextual scenarios in Aristotle's philosophy unveils fresh perspectives, thereby enriching the understanding of his philosophical framework.
Современные аспекты внутриутробной коррекции пороков развития плода: обзор литературы
Authors: Имангалиева Н.М. , Нурланова Г.К. , Исенова С.Ш. , Апселенова М.К. , Дадаева Л.Р. , Уркенова А.Ш.
Published: April 2024

Актуальность: Фетальная хирургия – это операция по вскрытию полости матки, хирургической коррекции аномалий развития плода и возвращению плода в матку для послеоперационного восстановления и продолжения гестационного развития. За последние 45 лет фетальная хирургия стала признанной областью инновационной хирургии. Был достигнут огромный прогресс в понимании естественной истории и патофизиологии заболеваний плода, решении технических задач фетальной хирургии, а также интра- и послеоперационном уходе и мониторинге отделения «мать-плод». Однако успех и широкое применение фетальной хирургии по-прежнему ограничены рядом серьезных нерешенных проблем. Фетальная терапия является логическим продолжением фетальной диагностики.Была выявлена группа заболеваний, которые потенциально могут быть скорректированы при лечении плода, включая нарушение мочеиспускания у плода.Цель исследования – изучение результатов инвазивных фетоскопических вмешательств и выявление современных подходов к своевременной и эффективной коррекции внутриутробных дефектов развития с целью уменьшения негативных перинатальных и материнских последствий.Материалы и методы: В литературный обзор включены данные научных статей и рекомендаций, опубликованных в базах PubMed, Cochrane Library, eLibrary, CyberLeninka.ru за последние 10 лет на русском и английском языках.Результаты: Операция на ребенке до рождения может показаться научной фантастикой, но дородовая хирургия становится все более распространенной. Фетоскопическая хирургия позволяет внутриутробно оказывать помощь беременным с многоплодной беременностью с тяжёлыми осложнениями. Проведение фетальной аортальной вальвулопластики способствует прекращению прогрессирования аортального стеноза в середине беременности и снижение развития синдрома гипоплазии левых отделов сердца. Одной из самых захватывающих разработок в области хирургии плода человека стало исследование заживления ран на коже плода без рубцов.Заключение: Хирургия плода – это новая область, которая быстро развивается, а современные методы антенатальной коррекции способны поменять естественное течение и исход заболевания. Однако некоторые разногласия по-прежнему нуждаются в разрешении. Необходимо разработать стандартизированные инструменты оценки и методы микрозабора крови плода, чтобы обеспечить дальнейшую разработку клинических протоколов. В этой связи изучение опыта ведущих центров является крайне актуальным для специалистов Казахстана.
Шетелдік студенттердің практикалық дағдыларын дамыту үшін CyberPatient™ платформасын пайдалану
Authors: Кулбаева С.Н. , Yadav Manish , Касаева Л.Т. , Токсанбаева Ж.С. , Салимбаева Б.Т. , Штобза О.С.
Published: April 2024

Өзектілігі: Медицина жоғарғы оқу орындарының студенттері үйренуге болатын алғашқы тәжірибелік қадамдардың бірі медициналық сұхбат жүргізу болып табылады. Виртуалды шындық студенттерге сенімді, стандартталған және үнемді онлайн құралдарды пайдалана отырып, анамнез жинау дағдыларын үйрену және тәжірибеде қолдану үшін қолайлы виртуалды клиникалық ортаны қамтамасыз ете алады. Көптеген зерттеушілер өздерінің мета-талдауында виртуалды науқастар студенттердің белгілі бір тақырыптар бойынша клиникалық пайымдау қабілетін жақсартуда тиімді деген қорытындыға келген.Зерттеудің мақсаты – CyberPatient™ платформасын пайдалана отырып шетелдік студенттерде анамнез жинау дағдыларын жетілдіруін, ары қарай диагностикалық іс-шараларды тағайындау және жүргізу барысында практикалық дағдыларды жақсартуды, сонымен қатар болжамды диагнозды қою тәжірибесін жетілдіруді бағалау.Материалдар мен әдістері: Мақсатқа жету үшін Акушерлік және гинекология кафедрасында «Гинекология» пәнінен «Жалпы медицина» мамандығы бойынша алыс шетелден келген студенттерге арналған практикалық сабақ шеңберінде (02-19 топ) CyberPatient™ платформасы пайдаланылды. Сабақ тақырыптары «Эндометриоз», «Климактериялық синдром» және «Әйел жыныс мүшелерінің қабыну аурулары» болып табылды. CyberPatient™ нақты өмірдегі пациенттерді имитациялайтын арнайы анимациялық аватарларды пайдалана отырып, онлайн платформада жасалған дайын сценарийлерді ұсынады.Нәтижелері: CyberPatient™ технологиясының жоғары тиімділігі дидактикалық міндеттерді сапалы шешу қабілетіне байланысты: студенттің құзыреттілігінің әртүрлі бастапқы деңгейін ескере отырып, жеке білім беру траекториясын құру, оқу ақпаратын көрнекі түрде ұсыну және кәсіби тапсырманы нақты модельдеу, оқу нәтижелерін объективті бақылау, кері байланысты тез алу, қателерді анықтау, өзін-өзі бақылау және өзін-өзі түзету және оқытудың мотивациялық аспектісін күшейтеді. Студент өз бетінше ешқандай көмексіз орындаған сәтте 100 баллдан тұратын ұпай жинайды. Егер бағалау парағына сәйкес студент қажетті балл жинамаса немесе 50 баллдан аз жинаса немесе кезеңдердің біреуінен өтпесе, ол осы критерийді орындамағанын көрсете отырып, бүкіл кезеңнен қайта өтуі қажет болып табылады.Қорытынды: CyberPatient™ бағдарламалық құралы – бұл клиникалық негіздеме мен дәрігерлік шешім қабылдау дағдыларын дамыту үшін сәтті пайдаланылуы мүмкін тиімді педагогикалық әдіс. Оң нәтижелерді ескере отырып, медициналық жоғары оқу орындары білім беру қызметінде CyberPatient™ технологияларын кеңінен қолдана алады, бірақ сапалы нәтиже алу үшін осы модельдеу технологиясын қолданыстағы оқу бағдарламаларына біріктіру жолдарын әзірлеу қажет табылады.
Experience in using biosimilars in IVF programs with donor oocytes in protocols with micronized progesterone
Authors: Abshekenova A.T. , Rybina A.N. , Askar E. , Karibaeva Sh.K. , Valiev R.K. , Lokshin V.N.
Published: April 2024

Relevance: Stimulation of oocyte donors' superovulation occupies a key place in the development of general assisted reproduction technology (ART). Oocyte donation programs involve young and healthy women undergoing severe ovarian stimulation protocols to obtain good-quality oocytes. Advances in recombinant DNA technology led to the development of recombinant follitropin alfa.The study aimed to evaluate the effectiveness of the biosimilar folitropin alfa in the superovulation stimulation cycles of oocyte donors in comparison with the original medication in Progestin primed ovarian stimulation (PPOS) protocols.Materials and Methods: A prospective cohort study included 25 oocyte donors who underwent superovulation induction. The first group consisted of 25 oocyte donors in whom superovulation was stimulated with a bio-analogue of follitropin alfa. The second group (control) included the same 25 oocyte donors stimulated with the original rFSH medication. The donors of the leading group were stimulated with biosimilar recombinant follicle-stimulating hormone and human menopausal gonadotropin. For the control group, a protocol was used using the original drug rFSH and CHMG in the same doses. The obtained donor oocytes were fertilized with ICSI or frozen. The program's result was determined by taking a blood test for b-hCG 14 days after embryo transfer.Results: The number of mature oocytes in the study groups did not differ significantly, amounting to 20.6 ± 1.1 in group 1 and 21.2 ± 1.3 in group 2. The average number of fertilized oocytes in group 1 was 5.6 ± 0.8, and in group 2 – 6.1 ± 1.1; thus, the fertilization rate in the two groups did not differ (67,5% in group 1 vs 79,2% in group 2, р> 0,05). The blastulation rate (49.1% in group 1 and 52.2% in group 2) did not differ significantly in both the biosimilar group and the original medication. The Top Quality Blastocysts in Group 1 were 1.5 ± 0.7 (55%) vs 1.8 ± 0.5 (48%) in Group 2. At the same time, the level of NNB in both groups also had no statistically significant differences.Conclusion: Sinnal-F was not inferior to the original medication in terms of the proportion of mature oocytes in oocyte donors. The study's results confirm that Synnal-f demonstrates favorable and comparable efficacy to the original medication in oocyte maturation in IVF/ICSI cycles.
Spiritual Oriented Cognitive-Based Group Therapy For Enhancing Resilience and Spiritual Well-Being Against Mobbing
Authors: Emül Büşra
Published: April 2024

This study examines the effect of spiritually oriented cognitive based group counseling on the resilience levels and spiritual well-being of individuals subjected to mobbing. The study used a quasi-experimental design with the control group (each group=11) with a pretest-posttest application. The mean age of the experimental group was 31.01, with a standard deviation of 6.04; the mean age of the control group was 33.09, with a standard deviation of 6.28. Eight sessions lasting 90 minutes were conducted with the experimental group. Cognitive and spiritual intervention to enhance resilience was applied to the experimental group. No intervention was applied to the control group. Measurement tools, Personal Information Form, Adult Resilience Scale, and Spiritual Well-Being Scale, were applied to the participants as pretest and posttest. Data were analyzed using Mann-Whitney U test and Wilcoxon Signed Ranks Test. As a result of the study, it was found that spiritually oriented cognitive-based group counseling was effective on the resilience levels and spiritual well-being of individuals who were subjected to mobbing. The findings were discussed within the framework of mobbing, resilience, and spirituality literature, and recommendations were presented.
The Correlation Between Working Posture and Work Duration and Non-Specific Neck Pain Symptoms in Computer User Employees
Authors: Mustafah Andi Siti Irfa Fidia , Hasbiah Nurhikmawaty , Rahmaniar Andi
Published: April 2024

Introduction: Longer work processes with non-ergonomic working postures by employees who use computers can certainly cause musculoskeletal tension. One of the musculoskeletal disorders (MSDs) associated with computer use is complaints of non-specific neck pain caused by a non-ergonomic posture of the neck muscles over a long period, which causes muscle tension. This study aims to determine the relationship between working posture and duration of work using a computer on non-specific neck pain complaints among Hasanuddin University Rectorate employees.Method: A cross-sectional research design was carried out on 121 administrative employees aged 22 years who met the inclusion and exclusion criteria. Assessment of working posture uses the Baseline Risk Identification of Ergonomic Factor (BRIEF) questionnaire, and for non-specific neck pain complaints using the Nordic Body Map (NBM) questionnaire. The Spearman's rho correlation test analyzes the relationship between variables.Results: 49 out of 121 respondents had a high-risk working posture for non-specific neck pain, and 59 out of 121 had a long working duration. Working posture is positively correlated with symptoms of non-specific neck pain (p = 0.001; r = 0.598). In contrast, work duration did not correlate with symptoms of non-specific neck pain (p = 0.063; r = 0.169).Conclusion: High-risk working postures can predict the incidence of non-specific neck pain in office administration employees. This can be a consideration for office leaders to pay attention to the working posture of their employees.Key words: Duration, non-specific neck pain, working posture
Deep Brain Stimulation for Alzheimer’s Disease: A Review of a Potential Treatment in Neurosurgery
Authors: Husodo Kharisma Ridho , Fa'izah Chintya Nur
Published: April 2024

Background: Alzheimer’s disease (AD) is still a disease with abundant enigma. Moreover, the prevalence of AD increases every year by about 10 million new cases. This disease is well known for its degenerative feature with age being the most influencing factor. Pathophysiologically, the deposition of beta-amyloid and tau proteins is the culprit for disrupting the neural connections in the brains of AD patients. Some studies have stated that drug medications are not effective in treating AD patients.Content: Currently, there is no drug to cure the disease. In conditions in which drugs fail to take effect, there is a therapy called deep brain stimulation (DBS), which allows the brain to be stimulated electrically using electrodes that are implanted into certain brain areas as targets. In AD patients, the nucleus basalis of meynert (NBM) and fornix are frequently selected as targets in DBS. This intervention is performed surgically by the neurosurgeon. Several potential mechanisms of this treatment include controlling connections among neurons, decreasing beta-amyloid and tau protein levels, and inhibiting the inflammation process in the brain.Conclusion: DBS can improve AD patients, both clinically and molecularly. Despite the promising effects of DBS, this treatment has limitations, so it cannot be applied to every patient with AD.
Congenital Nephrotic Syndrome: A Case Report
Authors: Rahma Sitti
Published: April 2024

Congenital nephrotic syndrome (CNS) is a rare disorder characterized by massive proteinuria, hypoalbuminemia, hyperlipidemia, and edema that occurs in the first three months of life. The incidence of CNS is about 1.5% of all cases of nephrotic syndrome in children, while the incidence in children is about 2 per 100,000. The pathogenesis of CNS is thought to be due to genetic defects in the components of the glomerular filtration barrier, particularly nephrin and podocin, which cause most similar cases. A perinatal infection may also cause CNS. The most common type of primary CNS is the Finnish type, inherited in an autosomal recessive manner. We report a case of a six-month-old male patient who presented with swelling of the face, abdomen, and genitals since the age of 3 months, which had worsened a week before admission to the hospital. There was no history of nausea, vomiting, fever, or seizures, and the child could drink milk. Physical examination revealed ascites with positive shifting dullness and pretibial, dorsum pedis, and scrotum edema. The liver and spleen were difficult to assess. Laboratory examination revealed leukocytosis (27.8x103/µL), anemia (7.7 g/dL), thrombocytosis (537x103/μL), hypoalbuminemia (1.5 g/dL), dyslipidemia (total cholesterol 374 mg/dL, HDL 7 mg/dL, LDL 69 mg/dL, triglycerides 1196 mg/dL), proteinuria (+3/300), and hematuria (+3/200). A history of urological ultrasound showed right and left nephropathy with mild hydronephrosis and ascites. To sum up, we reported male patient 6 months with congenital nephrotic syndrome. Chromosomal analysis is  recommended in  this case.
Child GAN: Face Aging and Rejuvenation to Find Missing Children
Authors: Reddy Y.V. Ragavendra , Kalaiarasi P. , Reddy M. Tejeswara , Charan Reddy K. Sri , Raj V. Ajay
Published: April 2024

The Child GAN project seeks in order to resolve the crucial problem of missing child location by utilizing state-of-the art machine learning methods, particularly Generative Adversarial Networks (GANs). The project's main goal is to create a novel method that uses face aging and rejuvenation algorithms to create age- progressed images of missing children. Our GAN-based model learns complex patterns of facial aging and rejuvenation by utilizing large datasets of facial images taken at different ages. Over time, the model can produce realistic representations of how missing children might age or look rejuvenated by training on pairs of images that show individuals at different stages of life. The age-progressed images that are produced are extremely useful resources for communities, non-profits, and law enforcement agencies that are looking for missing children. Through the use of various media channels, such as social media and traditional media, we hope to increase the visibility of these images of missing children and expedite their prompt recovery.
The Awakening of a Blazar at Redshift 2.7 Temporally Coincident with the Arrival of Cospatial Neutrino Event IceCube-201221A
Authors: Jiang Xiong , Liao Neng-Hui , Wang Yi-Bo , Xue Rui , Jiang Ning , Wang Ting-Gui
Published: April 2024

We report on multiwavelength studies of a blazar NVSS J171822+423948, which is identified as the low-energy counterpart of 4FGL J1718.5+4237, the unique γ-ray source known to be cospatial with the IceCube neutrino event IC-201221A. After a 12 yr long quiescent period undetected by Fermi-LAT, γ-ray activities with a tenfold flux increase emerge soon (a few tens of days) after the arrival of the neutrino. Associated optical flares in the Zwicky Transient Facility g, r, and i bands are observed together with elevated Wide-field Infrared Survey Explorer infrared fluxes. Synchronized variations suggest that both the γ-ray emission and the neutrino event are connected to the blazar. Furthermore, the optical spectrum reveals emission lines at a redshift z = 2.68 ± 0.01. Thus, it is the first candidate for a neutrino-emitting blazar at the redshift above 2. Discussions of theoretical constraints of neutrino production and comparisons with other candidates are presented.
An integrative taxonomic revision of the Trimeresurus popeiorum group of pitvipers (Reptilia: Serpentes: Viperidae) with descriptions of two new species from the Indo-Burma Biodiversity Hotspot
Authors: Idiiatullina Sabira S. , Nguyen Tan Van , Pawangkhanant Parinya , Suwannapoom Chatmongkon , Chanhome Lawan , Mirza Zeeshan A. , David Patrick , Vogel Gernot , Poyarkov Nikolay A.
Published: April 2024

Abstract

Despite recent progress in our understanding of diversity within the genus Trimeresurus Lacépède, 1804, the subgenus Popeia Malhotra & Thorpe, 2004, distributed across most parts of East and Southeast Asia, remains taxonomically challenging. We applied an integrative taxonomic approach including analyses of morphological data and four mitochondrial genes (12S and 16S rRNA, cytochrome b, and NADH dehydrogenase subunit 4), along with examination of available type material, to address longstanding taxonomic questions in one clade within Popeia, the T. popeiorum group, and reveal a high level of hidden diversity of these snakes in the Indo-Burma Biodiversity Hotspot. We confirm that T. popeiorum Smith, 1937 sensu stricto is restricted to Northeast India, eastern Nepal, southern Bhutan, southeastern Bangladesh, western Yunnan Province (China), and northern and southwestern Myanmar. We further confirm that the recently described species T. yingjiangensis Chen et al., 2019 is a junior synonym of T. popeiorum. In addition, we discovered that the combination Trimesurus [sic] elegans Gray, 1853 is a valid senior synonym of T. popeiorum and threatens the stability of the latter taxon. Therefore, in order to protect the nomen popeiorum and in accordance with Article 23.9 of the International Code of Zoological Nomenclature, we regard the taxon Trimesurus elegans as a nomen oblitum and render Trimeresurus popeiorum a nomen protectum. Examination of a larger series of specimens allows us to describe two new cryptic species of Trimeresurus from the Indo-Burma Region. This study brings the total number of species in the subgenus Popeia to six and also suggests that the subspecific taxonomy of the T. sabahi complex requires further investigation. We urge adequate actions regarding the conservation of the newly discovered species and recommend further studies on their toxicology.
Neo-Imperial Island Fantasy in Contemporary French Reality TV: The Case of Koh-Lanta
Authors: Bellec Marie
Published: April 2024

This article examines the literary elements of the French reality TV show Koh-Lanta. Drawing on the theory of reality TV, it demonstrates that this literary dimension facilitates the incorporation of neo-imperial elements. Koh-Lanta inscribes itself in the diversity of the intertext of the island fantasy, keeping the myth of Robinson up to date.
Cracking the Code
Authors: Kumar Thivashini B. Jaya , Rathakrishnan Thanuja
Published: April 2024

Escape rooms are a cutting-edge method of evaluating student learning because they give them a scenario in which they must solve issues and solve puzzles using numerous clues and contextual suggestions. The chapter intends to explore a discussion and reflection on the potential of immersive learning environments for formative assessments (escape room as a quiz) in enhancing students' learning experiences. The theoretical framework, the idea of an escape room, and how it might improve the learning process will be covered at the beginning of the chapter. This study employed a quasi-experimental design to investigate the effects of quiz format (digital quiz vs. digital escape room) on academic performance. Finally, the chapter discusses the potential challenges and limitations of escape room games in education. The chapter concludes by highlighting the insights, practical guidance, and future directions for educators interested in implementing escape room games in their teaching.
Comparative Overview of Augmented Reality, Virtual Reality, and Mixed Reality
Authors: Selvan C. , Vidhya K. , Senthil Kumar R. , Veningston K.
Published: April 2024

The virtual and augmented reality is a rapidly growing technology which focuses on visualization and recognition of 2D and 3D images using tools with bonded techniques (features). The virtual reality (VR) delivers only assumed digital world for viewers, but the expectations of viewers is real world with digital world. Thus, augmented reality (AR) has become popular to deliver enhanced view of VR. However, AR fulfilled the expectations of viewers but there is a gap between VR and AR. The intermediate gap is focused on enhanced visualization for controlling and manipulating VR and AR in parallel. In this chapter, the comparative study of VR, AR, and mixed reality (MR) are focused to expose different aspects of applications, performances, and tools requirements.
Augmented Reality and Virtual Reality Modules for Mindfulness
Authors: Singh Bhupinder , Kaunert Christian
Published: April 2024

Augmented reality (AR) and virtual reality (VR) modules are emerging as revolutionary tools for improving mindfulness, emotional intelligence, and mental health. These immersive technologies provide a one-of-a-kind and engaging platform for simulating real-life settings and guiding users through a variety of experiences aimed at regulating emotions and improving mental health. These modules can teach and reinforce mindfulness practices by immersing users in virtual worlds, allowing them to get a better awareness of their emotions, manage stress, and build emotional resilience. AR and VR modules are proving to be strong tools for personal growth and well-being, whether through guided meditation, stress reduction exercises, or interactive situations aimed at increasing empathy and self-awareness. This chapter comprehensively explores the transformational potential of AR and VR modules in building mindfulness, enhancing emotional intelligence, and contributing to overall mental well-being.
The Neuropsychological Impact of Immersive Experiences in the Metaverse and Virtual and Augmented Reality
Authors: De Clara Laura
Published: April 2024

Recent advances in mental healthcare technology, especially in virtual reality (VR) and augmented reality (AR), have revolutionized psychiatry and psychology. This chapter critically examines these innovations' potential in treating various mental disorders, from anxiety and depression to PTSD and ADHD. It emphasizes the controlled and customizable nature of VR environments, which empower individuals to confront fears within personalized settings. Interdisciplinary collaboration is stressed, showcasing applications in psychology, from assessment to clinical treatment. The chapter explores neuropsychological impacts, detailing how VR modulates emotions, enhances neural plasticity in stroke rehabilitation, and alters neural networks. Despite promise, challenges like treatment standardization and ethical concerns persist, demanding careful consideration. The chapter advocates for ongoing research and global interdisciplinary cooperation to fully exploit these technologies' potential in mental healthcare.