bluuebunny/crossref_metadata_2025 huggingface dataset:
SMRFIT: A STATISTICAL ANALYSIS SYSTEM (SAS) PROGRAM FOR STANDARDIZED MORTALITY RATIO ANALYSES AND POISSON REGRESSION MODEL FITS IN COMMUNITY DISEASE CLUSTER INVESTIGATIONS
Authors: HANRAHAN LAWRENCE P. , MIRKIN IRENE , OLSON JOSEPH , ANDERSON HENRY A. , FIORE BETH J.
Published: February 2017

Increasingly, health departments are being pressed by the public to respond to disease risk with cluster investigations in communities and neighborhoods. This is a direct result of growing concern about the role that the environment may play in disease risk. While extensive analyses directly inputing exposures or numbers at risk are often necessary to thoroughly investigate clusters, it is quite useful to perform an exploratory analysis with existing morbidity and mortality data as a first level of response. To meet this need for timely evaluation, the authors describe a user-friendly Statistical Analysis System (SAS) program called SMRFIT to automate community disease cluster evaluations. The program creates frequency tables for number at risk and number of disease outcomes for the community, balance of parent county, and balance of state. SMRFIT then constructs standardized mortality ratios, with the community compared with balance of county and balance of state referents. Poisson regression is offered as an option for the modeling of community disease rates.
STATE HEALTH DEPARTMENT RESPONSE TO DISEASE CLUSTER REPORTS: A PROTOCOL FOR INVESTIGATION
Authors: FIORE BETH J. , HANRAHAN LAWRENCE P. , ANDERSON HENRY A.
Published: February 2017

State health departments are increasingly faced with the task of responding to reports of apparent cancer and other disease clusters. Since 1979, 141 requests for investigation have been received by the Wisconsin Division of Health, with over 60% of these requests occurring since 1985. Mounting public concern and limited resources have resulted in the development of a “disease cluster investigation and analysis protocol.” Protocol steps include: 1) circumscribing the cluster; 2) ascertaining cases; 3) assessing risk of the exposed versus a referent population; 4) statistically analyzing disease rates; 5) examining potential exposure; 6) assessing biologic plausibility; 7) determining cluster significance and need for further investigation; and 8) reporting results. To demonstrate the protocol, the authors present a case example of an investigation of an apparent cancer cluster. Since 1979, 62 reports were resolved with initial contact with informant education (step 1), 61 reports required descriptive analysis (steps 1-8) with no site visit, and 18 reports required site visits. None of the reports required further in-depth epldemiologic investigation. This protocol provides a systematic approach to investigation and analysis, prioritizes the need for more in-depth study, and, when necessary, assuages community concerns when a disease cluster is reported.
QUALITATIVE AND QUANTITATIVE ASSESSMENT OF GEOGRAPHIC CLUSTERING OF POPULATION SAMPLES SELECTED USING DIFFERENT METHODS OF RANDOM DIGIT DIALING
Authors: DAVIS SCOTT , ROSS ANDREW , VOIGT LYNDA F. , HEUSER LINDA
Published: February 2017

Random digit dialing is a method commonly used to select random population samples in epidemiologic research. Although random digit dialing is generally presumed to provide representative samples, coverage and nonresponse errors may affect the degree to which the sample is representative. The present investigation was undertaken to determine whether the geographic distributions of samples selected using variations of the basic random digit dialing technique accurately reflect the underlying population distribution, and if not, whether such samples tend to be either more or less dispersed than the populations from which they were selected. Data regarding control groups from three case-control studies conducted from 1983–1986 were utilized. The residence addresses of 998 controls were located and assigned an X-Y coordinate and census tract designation within a three-county geographic area in northwest Washington State. Initially, the spatial distributions of controls were examined graphically in relation to the age-sex structure of the underlying population. No differences in geographic pattern were apparent A more formal statistical evaluation was conducted based on centrographic techniques utilizing two measures to describe the spatial distribution of a set of points. Results indicate that the samples chosen were neither more nor less dispersed than the underlying populations. However, the geographic centers of samples selected using primary numbers tended to be shifted from the centers of their respective populations. Several possible explanations for such shifts are considered, and extensions of the analytical approach are suggested in relation to the further evaluation of population sampling and the investigation of space-time aggregations of disease.
The Development and Significance of the Root Nodules of Casuarina
Authors: BOND G.
Published: February 2017

Young plants of Casuarina cunninghamiana and of C. equisetifolia growing in water culture developed macroscopic nodules in 26 to 35 days from inoculation, the nodulation being most successful at pH near to neutrality and falling off much more rapidly at lower pH than in other non-legume nodule-forming genera, confirming the distinctiveness of the Casuarina organism. The roots springing from the nodule lobes are shown to be characterized by upward growth and in this to resemble remarkably closely the corresponding roots of Myrica. Nodulated plants of Casuarina are able to grow vigorously in culture solution free of combined nitrogen, showing that fixation of atmospheric nitrogen occurs, amounting in C. cunninghamiana to 50 mg. per plant during 6 months of active growth. The evidence indicates that the fixation occurs in the nodules, and that these have exactly the same functional significance as those of legumes.
Scaling single cell transcriptomics through split pool barcoding
Authors: Rosenberg Alexander B. , Roco Charles M. , Muscat Richard A. , Kuchina Anna , Mukherjee Sumit , Chen Wei , Peeler David J. , Yao Zizhen , Tasic Bosiljka , Sellers Drew L. , Pun Suzie H. , Seelig Georg
Published: February 2017

Constructing an atlas of cell types in complex organisms will require a collective effort to characterize billions of individual cells. Single cell RNA sequencing (scRNA-seq) has emerged as the main tool for characterizing cellular diversity, but current methods use custom microfluidics or microwells to compartmentalize single cells, limiting scalability and widespread adoption. Here we present Split Pool Ligation-based Transcriptome sequencing (SPLiT-seq), a scRNA-seq method that labels the cellular origin of RNA through combinatorial indexing. SPLiT-seq is compatible with fixed cells, scales exponentially, uses only basic laboratory equipment, and costs one cent per cell. We used this approach to analyze 109,069 single cell transcriptomes from an entire postnatal day 5 mouse brain, providing the first global snapshot at this stage of development. We identified 13 main populations comprising different types of neurons, glia, immune cells, endothelia, as well as types in the blood-brain-barrier. Moreover, we resolve substructure within these clusters corresponding to cells at different stages of development. As sequencing capacity increases, SPLiT-seq will enable profiling of billions of cells in a single experiment.
Cancer Cell Line Profiler (CCLP): a webserver for the prediction of compound activity across the NCI60 panel
Authors: Cortés-Ciriano Isidro , Murrell Daniel S. , Chetrit Bernard , Bender Andreas , Malliavin Thérèse , Ballester Pedro J.
Published: February 2017

CCLP (CancerCellLineProfiler) is a webserver for the prediction of compound activity across the NCI60 panel. CCLP uses a multi-task Random Forest model trained on 941,831 data-points that integrates structural information from 17,142 compounds and multi-omics data sets from 59 cancer cell lines. In addition, CCLP also implements conformal prediction to provide individual prediction errors at several confidence levels. CCLP computes compound descriptors for a set of input molecules and predicts their activity across the NCI60 panel. The output of running CCLP consists of one barplotperinput compound displaying the predicted activities and errors across the NCI60 panel, as well as a text file reporting the predicted activities and errors in prediction

Availability

CCLP is freely available on the web atcclp.marseille.inserm.fr
Ethyl 3-[3-amino-4-methylamino-N-(pyridin-2-yl)benzamido]propanoate
Authors: Wen Gao-Ju , Wang Ming-Xin , Gu Lian-Shuai
Published: February 2017

In the title compound, C18H22N4O3, the benzene ring is twisted by 63.29 (15)° with respect to the pyridine ring. In the crystal, molecules are linked by N—H...O hydrogen bonds and C—H...π interactions, forming slabs parallel to theacplane.
1-(3-Phenyl-1H-pyrazol-5-yl)-1,2,3,4-tetrahydroquinoxaline-2,3-dione
Authors: Ghomsi Nathan Joseph Tene , Hamou Ahabchane Noureddine , Sebbar Nada Kheira , Essassi El Mokhtar , Mague Joel T.
Published: February 2017

In the title compound, C17H12N4O2, the mean plane of the pyrazole ring is nearly perpendicular to that of the tetrahydroquinoxalinedione moiety [dihedral angle = 86.92 (7)°]. The phenyl ring is disordered over two orientations in a 0.556 (4):0.444 (4) ratio. In the crystal, molecules are connected by bifurcated N—H...(N,O) and N—H...(O,O) hydrogen bonds, generating (100) sheets. Aromatic π–π stacking [shortest centroid–centroid separation = 3.5307 (8) Å] links the sheets into a three-dimensional network. A short N...O contact [2.8198 (19) Å] is present.
2,5-Bis[(3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl)sulfanyl]-1,3,4-thiadiazole
Authors: Partl Gabriel , Laus Gerhard , Wurst Klaus , Kopacka Holger , Müller Thomas , Huppertz Hubert , Schottenberger Herwig
Published: February 2017

The title compound, C18H8F26N2S3, was obtained by doubleS-perfluorohexylethylation of dipotassium 1,3,4-thiadiazole-2,5-dithiolate in methanol. The molecule exhibits twofold rotational symmetry, with the S atom lying on the rotation axis. The fluorocarbon chains adopt helical conformations and the F atoms of the two terminal C atoms are disordered over two sets of sites. No directional intermolecular interactions occur in the crystal.
3-Chloro-6-nitro-1-[(1-octyl-1H-1,2,3-triazol-4-yl)methyl]-1H-indazole
Authors: Mohamed Abdelahi Mohamed Mokhtar , Boulhaoua Mohammed , Essaghouani Abdelhanine , Benchidmi Mohammed , Essassi El Mokhtar , Mague Joel T.
Published: February 2017

The asymmetric unit of the title compound, C18H23ClN6O2, consists of two independent molecules differing primarily in the dihedral angles between the mean planes of the indazole and triazole moieties [78.50 (8) in one and 72.39 (7)° in the other]. One of the molecules shows positional disorder of the terminal part of its octyl chain. In the crystal, C—H...X(X= Cl, N, O) hydrogen bonds and C—H...π and π-stacking interactions are observed: together these generate a three-dimensional network.
3,5-Diamino-4H-1,2,4-triazol-1-ium 4-nitrobenzoate dihydrate
Authors: Lahmidi Sanae , Essassi El Mokhtar , Benchidmi Mohammed , Saadi Mohamed , El Ammari Lahcen
Published: February 2017

The crystal of the title salt hydrate, C2H6N5+·C7H4NO4−·2H2O, is built up from a 3,5-diamino-4H-1,2,4-triazol-1-ium cation linked to a 4-nitrobenzoate anion and to two water molecules through strong hydrogen bonds. The triazolyl ring is virtually planar, with the maximum deviation from the mean plane being 0.003 (1) Å. Small twists are noted in the anion with the dihedral angles between the ring and carboxylate and nitro groups being 7.82 (13) and 9.10 (15)°, respectively. In the crystal, molecules are linked by N—H...O, N—H...N, O—H...O and C—H...O interactions, forming layers parallel to (-101). The sheets are linked by O—H...O hydrogen bonds and π–π interactions between triazole and benzene rings [inter-centroid separation = 3.4967 (8) Å] to form a three-dimensional structure.
1,1′-{(1E,1′E)-[Octane-1,8-diylbis(azanylylidene)]bis(methanylylidene)}bis(naphthalen-2-ol) in the zwitterionic form
Authors: Bendia Sabrina , Ouari Kamel , Karmazin Lydia
Published: February 2017

The title compound, C30H32O2N2, is formed from two units ofortho-hydroxynaphthaldehyde bridged with 1,8-diaminooctane. In the solid state, it exists as a double zwitterion. The N atoms are protonated and the C—O−bonds lengths are 1.265 (2) Å, with intramolecular N—H...O hydrogen bonds formingS(6) ring motifs. The molecule has twofold rotational symmetry, with the twofold axis bisecting the central –CH2—CH2– bond of the bridging octane chain. In the crystal, molecules are linked by N—H...O hydrogen bonds, forming chains propagating along the [-201] direction. The chains are linkedviaC—H...O hydrogen bonds, forming a supramolecular three-dimensional framework structure.
Brand religiosity
Authors: Sarkar Juhi Gahlot , Sarkar Abhigyan
Published: February 2017

Purpose

The purpose of this paper is to define the brand religiosity phenomenon and develop a theoretical process model showing the interrelationships between brand religiosity and other related concepts leading to the formation of a distinct brand sub-culture or community.

Design/methodology/approach

A large volume of prior literature on consumer–brand relationships has been reviewed to develop the conceptual framework.

Findings

The framework developed shows several actionable antecedents and desirable marketing outcomes of brand religiosity. The framework also depicts that brand religiosity leads to the creation of social anti-structure by forming a distinct brand community that frees individuals from the regular social structure and motivates them to adopt a distinct brand sub-culture formed. Theoretical contributions and business policy-related implications of brand religiosity are discussed.

Originality/value

Value of the study lies in conceptualizing brand religiosity and developing an integrative process model centering the concept.
Effect of visceral pleural invasion on the prognosis of patients with lymph node negative non‐small cell lung cancer
Authors: Tian Dan , Pei Yuquan , Zheng Qingfeng , Zhang Jianzhi , Li Shaolei , Wang Xing , Lin Dongmei , Yang Yue
Published: February 2017

Background

Visceral pleural invasion (VPI) is an adverse prognostic factor in non‐small cell lung cancer (NSCLC); however, its effect in relation to tumor size remains under debate. To better understand the prognostic impact and potential consequences for staging, we examined correlations between VPI and clinicopathologic characteristics in patients with NSCLC, particularly those with lymph node negative NSCLC.

Methods

We retrospectively analyzed 813 cases of radically resected NSCLC treated in our institution between December 2005 and December 2011. Patients were divided into two groups according to VPI status to compare their clinicopathologic characteristics. Survival analysis was performed in 521 cases with pN0 NSCLC.

Results

VPI was diagnosed in 379 (46.6%) cases. It was more common in women, patients with non‐squamous cell carcinoma, elevated preoperative serum carcinoembryonic antigen levels, moderately or poorly differentiated tumors, and larger‐sized tumors. The incidence of mediastinal lymph node metastasis, particularly multi‐station metastasis, was higher in patients with VPI. Patients with pN0 NSCLC, 2–3 cm tumors, and VPI had a significantly poorer prognosis (VPI vs. non‐VPI: five‐year overall survival 78.3% vs. 84.5%, P = 0.039; five‐year disease‐free survival 69.2% vs. 80.0%, P = 0.046, respectively); however, no significant effect was observed for tumors ≤2, 3–5, and 5–7 cm. P‐N0 patients with VPI had a significantly higher incidence of postoperative local recurrence and distant metastasis than those without VPI (P = 0.01), especially ipsilateral pleural recurrence.

Conclusion

VPI was an adverse prognostic factor in radically resected pN0 NSCLC, especially for tumors 2–3 cm in size.
Analysing model fit of psychometric process models: An overview, a new test and an application to the diffusion model
Authors: Ranger Jochen , Kuhn Jörg‐Tobias , Szardenings Carsten
Published: February 2017

Cognitive psychometric models embed cognitive process models into a latent trait framework in order to allow for individual differences. Due to their close relationship to the response process the models allow for profound conclusions about the test takers. However, before such a model can be used its fit has to be checked carefully. In this manuscript we give an overview over existing tests of model fit and show their relation to the generalized moment test of Newey (Econometrica, 53, 1985, 1047) and Tauchen (J. Econometrics, 30, 1985, 415). We also present a new test, the Hausman test of misspecification (Hausman, Econometrica, 46, 1978, 1251). The Hausman test consists of a comparison of two estimates of the same item parameters which should be similar if the model holds. The performance of the Hausman test is evaluated in a simulation study. In this study we illustrate its application to two popular models in cognitive psychometrics, the Q‐diffusion model and the D‐diffusion model (van der Maas, Molenaar, Maris, Kievit, & Boorsboom, Psychol Rev., 118, 2011, 339; Molenaar, Tuerlinckx, & van der Maas, J. Stat. Softw., 66, 2015, 1). We also compare the performance of the test to four alternative tests of model fit, namely the M2 test (Molenaar et al., J. Stat. Softw., 66, 2015, 1), the moment test (Ranger et al., Br. J. Math. Stat. Psychol., 2016) and the test for binned time (Ranger & Kuhn, Psychol. Test. Asess. Model., 56, 2014b, 370). The simulation study indicates that the Hausman test is superior to the latter tests. The test closely adheres to the nominal Type I error rate and has higher power in most simulation conditions.
Unraveling the roles of orienting and inhibition in the Concealed Information Test
Authors: klein Selle Nathalie , Verschuere Bruno , Kindt Merel , Meijer Ewout , Ben‐Shakhar Gershon
Published: February 2017

The Concealed Information Test (CIT) is a well‐validated tool for physiological and behavioral detection of concealed knowledge. Two distinct theoretical frameworks have been proposed to explain the differential responses to the concealed critical items: orienting response theory versus arousal inhibition theory. klein Selle, Verschuere, Kindt, Meijer, and Ben‐Shakhar (2016), however, argued for a response fractionation model and showed that, while the skin conductance reflects pure orienting, both the respiratory and heart rate measures reflect arousal inhibition. The present study intends to (1) provide a constructive replication of klein Selle et al. (2016) using the autobiographical CIT, and (2) extend their work by testing an additional prediction derived from orienting theory, using an item‐salience manipulation. One hundred and nine participants were tested on four high salient and four low salient identity items. Half of the participants were motivated to hide their identity (orienting + arousal inhibition), while the other half were motivated to reveal their identity (orienting only). Confirming earlier findings, the results revealed a fractionation between the different measures: while the skin conductance response (SCR) increased to a similar extent in the two motivational conditions, the respiration line length (RLL) shortened and the heart rate (HR) decelerated solely in the conceal condition. Moreover, while the SCR was larger for high than for low salient critical items, the RLL and HR responses were similar for these two item types. These data led us to conclude that, in the CIT, the skin conductance measure reflects orienting and the respiratory and heart rate measures reflect arousal inhibition.
Investigating laparoscopic psychomotor skills in veterinarians and veterinary technicians
Authors: Kilkenny Jessica , Santarossa Amanda , Mrotz Victoria , Walker Meagan , Monaghan Dominique , Singh Ameet
Published: February 2017

Objectives

To determine the influence of age, year of graduation, and video game experience on baseline laparoscopic psychomotor skills.

Study design

Cross‐sectional.

Sample Population: Licensed veterinarians (n = 38) and registered veterinary technicians (VTs) (n = 49).

Methods

A laparoscopic box trainer was set up at the 2016 Ontario Veterinary Medical Association (OVMA) and the 2016 Ontario Association of Veterinary Technicians (OAVT) conferences held in Toronto, Ontario, Canada. Participants volunteered to perform a single repetition of a peg transfer (PT) exercise. Participants were given a short demonstration of the PT task prior to testing. A Spearman's rank correlation (rs) was used to identify associations between baseline psychomotor skills and self‐reported surgical and non‐surgical experiences collected via survey. Mann‐Whitney U tests were used to compare PT scores in veterinarians and VTs. A P‐value of < .05 was considered significant.

Results

The mean age of participants was 36 years (range 21‐67) and the majority were female (83%). In veterinarians, PT scores were highest in the most recent graduates (P = .01, rs = 0.42), and PT scores increased with self‐reported VG experience (P = .02, rs = 0.38). PT scores correlated inversely with age (P = .02, rs = −0.37). No associations were observed in VTs (P > .05). Veterinary technicians that frequently used chopsticks scored higher than those without chopstick experience (P = .04).

Conclusions

Age and year of graduation correlated inversely, while self‐reported VG experience correlated positively with laparoscopic psychomotor skills of veterinarians, when assessed on a simulator. The use of chopsticks may contribute to the acquisition of psychomotor skills in VTs.
Simultaneous microbial removal of carbon, nitrogen, and phosphorus in a modified anaerobic/aerobic (A/O) bioreactor with no phosphorus release
Authors: Luo Weishi , Peng Xingxing , Jing Fei , Zhang Zaili , Jia Xiaoshan
Published: February 2017

A modified anaerobic/aerobic (A/O) bioreactor that simultaneously removed carbon, nitrogen (
‐N) and phosphorus (
‐P) was continuously run and debugged. After 34 days of reactor operation, the removal efficiencies of
‐N, carbon (glucose) and
‐P reached 99.26, 95.81 and 94.35%, respectively. Notably, the ammonium removal with no accumulation of nitrite (
‐N) and nitrate (
‐N) in the anaerobic part supported the occurrence of simultaneous nitrification and denitrification and no
‐P was released during the removal process of phosphorus. Moreover, the principal component analysis and response surface methodology based on the Box–Behnken design were applied to determine the optimal removal conditions for volatile suspended solids (VSS) (335 mg/L),
‐N (60 mg/L), glucose (900 mg/L) and pH (7). Finally, phylogenetic analysis of the bacterial consortium was conducted by denaturing gradient gel electrophoresis, which demonstrated that Clostridium and Proteobacteria were the potential functional groups in the anaerobic tank of the A/O bioreactor.
Cost Requirements for a Small-Scale SOFC Fed From Agricultural-Derived Biogas
Authors: Majerus Samuel , Lauinger Dirk , Van herle Jan
Published: February 2017

In this work, the use of fuel cells for valorizing agricultural-derived biogas in Switzerland is studied. The Swiss agricultural case is characterized by farms with small numbers of animals (20 cows) and high feed-in tariffs (FIT) for biogas-derived electricity (0.49 CHF/kWhel). Thus, small-scale biogas installations are reviewed and the possibility to couple them with solid oxide fuel cells (SOFCs) and photovoltaic (PV) panels is analyzed. To date, less than 5% of the Swiss agricultural biogas potential is used. It is possible to increase this value significantly up to 86% through the deployment of 2 kWel engines. The small size of the Swiss farm requires biogas installations in the kW-range. Small-scale biogas facilities are not profitable yet: the main challenge is to bring down the lifetime cost of the fuel cells to 11,000 CHF/kWel (considering a lifetime of ten years) and to reduce the investment cost (IC) of small-scale biogas facilities to around 9500 CHF/kWch. In the kW-range, solid oxide fuel cells (SOFCs) have higher electrical conversion efficiencies than internal combustion engines (ICEs). It is shown that SOFCs become competitive over combustion engines if the investment cost of the former decreases below 13,000 CHF/kWel for a lifetime of 11 years. Combining the biogas facility with a PV-battery system, which covers the digester's electricity needs, is found to be beneficial. A considerable reduction in the feed-in tariffs would make small- to medium-scale biogas installations unprofitable, at current cost. In order to reach a break-even under these conditions, the investment cost of the biogas plant needs to drop below 4000 CHF/kWch, whereas the investment cost of the SOFC needs to drop below 3400 CHF/kWel.
Minimizing Transmission Loss in Smart Microgrids by Sharing Renewable Energy
Authors: Huang Zhichuan , Zhu Ting , Irwin David , Mishra Aditya , Menasche Daniel , Shenoy Prashant
Published: February 2017

Renewable energy (e.g., solar energy) is an attractive option to provide green energy to homes. Unfortunately, the intermittent nature of renewable energy results in a mismatch between when these sources generate energy and when homes demand it. This mismatch reduces the efficiency of using harvested energy by either (i) requiring batteries to store surplus energy, which typically incurs ∼ 20% energy conversion losses, or (ii) using net metering to transmit surplus energy via the electric grid’s AC lines, which severely limits the maximum percentage of renewable penetration possible. In this article, we propose an alternative structure where nearby homes explicitly share energy with each other to balance local energy harvesting and demand in microgrids. We develop a novel energy sharing approach to determine which homes should share energy, and when to minimize system-wide energy transmission losses in the microgrid. We evaluate our approach in simulation using real traces of solar energy harvesting and home consumption data from a deployment in Amherst, MA. We show that our system (i) reduces the energy loss on the AC line by 64% without requiring large batteries, (ii) performance scales up with larger battery capacities, and (iii) is robust to different energy consumption patterns and energy prediction accuracy in the microgrid.
Motivation and life satisfaction of temporary workers: measurement validity using Self-determination Theory
Authors: Batista Josilene , Chambel Maria José
Published: February 2017

O tema das motivações é amplamente estudado no campo da psicologia e, apesar de reconhecida a sua importância, são limitadas as pesquisas especificamente relacionada ao trabalho temporário. Este estudo foi realizado com 812 trabalhadores temporários em Portugal, com o objetivo buscar evidências da validade de uma medida para acessar suas motivações de acordo com a teoria da autodeterminação (SDT). Procedimentos estatísticos foram realizados, nomeadamente análises fatoriais exploratória e confirmatória. Os resultados revelam que a estrutura proposta de dois fatores apresenta boa qualidade dos valores dos índices de ajustamento, bem como valores adequados de validade convergente e discriminante, sendo válida e permitindo sua aplicação prática e em futuras investigações. Embora instrumentos como este sejam inovadores e promissores para avaliar o contexto do trabalho temporário, sugere-se a realização de mais investigações buscando mais evidências de validade favorecendo a ampliação do conhecimento sobre suas características psicométricas, inclusivamente outras variáveis
Female sex workers and the excessive consumption of alcohol
Authors: Bonifácio Daniela Pereira Di , Tilio Rafael De
Published: February 2017

A prostituição é considerada uma das profissões mais antigas existentes, porém ainda é muito discriminada (por motivos como promiscuidade, pecado e ameaça à saúde) e apresenta fatores de risco, dentre eles, o consumo excessivo de bebidas alcoólicas. O objetivo desta pesquisa foi investigar o consumo de álcool por profissionais do sexo feminino, indagando sobre os principais fatores ambientais envolvidos, a trajetória de vida e relações sociais das profissionais. Foram realizadas entrevistas com seis participantes, todas profissionais do sexo numa cidade do Triângulo Mineiro/MG. Os principais resultados apontam que o ambiente de trabalho e o elevado consumo de bebidas alcoólicas pelas profissionais do sexo estão relacionados à comissão que elas recebem por este consumo, porém com consequências para a própria saúde que nem sempre são reconhecidos. Além disso, as participantes dissociam suas identidades entre a do mundo do trabalho e das demais relações sociais como estratégia de enfrentamento das dificuldades no mundo do trabalho
A influência do Parecer GQ n. 145/98 da AGU nas acumulações de cargos públicos
Authors: Silva Marina Corrêa da , Ferreira Dirce Nazare de Andrade
Published: February 2017

A presente pesquisa abordou a acumulação de cargos a partir da previsão do texto constitucional tendo como enfoque a questão da compatibilidade de horários diante do entendimento da Advocacia-Geral da União (AGU) constante no parecer GQ n. 145/1998. Essa posição da AGU recomenda que o servidor público em acumulação de cargos perfaça jornada laboral de no máximo 60 (sessenta) horas semanais e, embora tenha efeito vinculante no âmbito da Administração Pública Federal, ainda não há um entendimento firmado pelos tribunais pátrios acerca da matéria. A metodologia adotada para o desenvolvimento do trabalho trata-se da revisão bibliográfica e análise documental e tem a presente pesquisa como objetivo apontar os impactos da edição do parecer GQ 145/98 nas situações de acumulação de cargos no âmbito da Administração Pública Federal.
Tamoxifen Directly Inhibits Platelet Angiogenic Potential and Platelet-Mediated Metastasis
Authors: Johnson Kelly E. , Forward Jodi A. , Tippy Mason D. , Ceglowski Julia R. , El-Husayni Saleh , Kulenthirarajan Rajesh , Machlus Kellie R. , Mayer Erica L. , Italiano Joseph E. , Battinelli Elisabeth M.
Published: February 2017

Objective—

Platelets, which are mainly known for their role in hemostasis, are now known to play a crucial role in metastasis. Tamoxifen is a selective estrogen receptor modulator that is widely used for the treatment of breast cancer. Tamoxifen and its metabolites have been shown to directly impact platelet function, suggesting that this drug has additional mechanisms of action. The purpose of this study was to determine whether tamoxifen exerts antitumor effects through direct platelet inhibition.

Approach and Results—

This study found that pretreatment with tamoxifen leads to a significant inhibition of platelet activation. Platelets exposed to tamoxifen released significantly lower amounts of proangiogenic regulator vascular endothelial growth factor. In vitro angiogenesis assays confirmed that tamoxifen pretreatment led to diminished capillary tube formation and decreased endothelial migration. Tamoxifen and its metabolite, 4-hydroxytamoxifen, also significantly inhibited the ability of platelets to promote metastasis in vitro. Using a membrane-based array, we identified several proteins associated with angiogenesis metastasis that were lower in activated releasate from tamoxifen-treated platelets, including angiogenin, chemokine (C-X-C motif) ligand 1, chemokine (C–C motif) ligand 5, epidermal growth factor, chemokine (C-X-C motif) ligand 5, platelet-derived growth factor dimeric isoform BB, whereas antiangiogenic angiopoietin-1 was elevated. Platelets isolated from patients on tamoxifen maintenance therapy were also found to have decreased activation responses, diminished vascular endothelial growth factor release, and lower angiogenic and metastatic potential.

Conclusions—

We demonstrate that tamoxifen and its metabolite 4-hydroxytamoxifen directly alter platelet function leading to decreased angiogenic and metastatic potential. Furthermore, this study supports the idea of utilizing targeted platelet therapies to inhibit the platelet’s role in angiogenesis and malignancy.
Typification of Ardisia blatteri (Primulaceae)
Authors: ROY RIJUPALIKA , ROY ANIRBAN , PRAMANIK ARABINDA
Published: February 2017

Ardisia blatteri Gamble (1921: 121) is endemic to India and occurs in the southern part of Western Ghats (Dhanasekaran et al. 2016). This species has been considered as ‘Endangered’ in IUCN Red List of Threatened Species (IUCN 2016). The plants are rich in chemical constituents like alkaloids, tannins, saponins, anthraquinones, phenols, terpenoids and flavonoids, coumarins, steroids and phytosteroids and are used in traditional medicines (Dhanasekaran et al. 2016) for curing fever, cough, rheumatism, inflammation and many more ailments. The medicinal properties of this important plant require further research.
Ultrasound‐Guided Needle Biopsy for Diagnosis of Advanced‐Stage Malignancies of the Upper Aerodigestive Tract
Authors: Smith Aaron , Grady Anthony , Vieira Francisco , Sebelik Merry
Published: February 2017

Objective

Traditionally, direct laryngoscopy confirms stage and tissue diagnosis prior to treatment planning. Patients who are frail or have tenuous airway anatomy may incur risks while undergoing anesthesia. Further, direct laryngoscopy is scheduled after initial examination, introducing diagnosis delay. This study investigates the impact of ultrasound examination with guided needle biopsy compared with traditional operative biopsy.

Study Design

Case series.

Setting

Tertiary head and neck clinic.

Subjects and Methods

The records of patients at the Veterans Affairs Medical Center Memphis and Regional One Health who had supraglottic, oropharyngeal, and hypopharyngeal cancer that was diagnosed by ultrasound needle biopsy were reviewed from 2011 to 2016. Demographics, stage, biopsy results, and treatment were abstracted.

Results

Seventeen patients who underwent ultrasound‐guided needle biopsy of the primary site were included. Average age was 63 years old, and 65% of patients were stage T4 (11/17). Needle biopsy yielded malignant cells in 76% (13/17). Eleven patients were included in subsequent analysis because 6 patients underwent needle biopsy only. Fisher exact test showed no difference between the 2 methods (P =. 27). Sensitivity was 86% and specificity was 100%. Seven patients had a median potential delay in diagnosis of 10 days.

Conclusions

Ultrasound can be used effectively to obtain a tissue diagnosis, circumventing an operative biopsy. Moreover, ultrasound may provide additional imaging details to support accurate staging. This strategy may prove worthwhile to cut costs and reduce delay to staging, reduce risk for those with contraindications to anesthesia, and increase staging accuracy via enhanced imaging details.
Basics of Monitoring of the Effectiveness of Accounting Statutory Regulation
Authors: Поленова  , Polenova S.
Published: February 2017

The article attempts to analyze the reasons for the low effectiveness of the modern system of accounting statutory regulation, provided by the Federal Law «On Accounting» and the high costs of economic agents related to the implementation of its main provisions.
short subject: Expanded epistemologies: Animation meets live action in contemporary Swedish documentary film
Authors: Rozenkrantz Jonathan
Published: February 2017

This short subject studies configurations of animation and live action in contemporary Swedish documentary film. While digitization has challenged the indexical image’s verifying function, animation has been elevated to the level of legitimate document. The epistemological boundaries of documentary film have consequently been expanded, and now include the inner worlds of social subjects. In Gömd (Hidden) (Heilborn and Aronowitsch, 2002), animation and live action are repeatedly juxtaposed in order to visualize a refugee child’s experienced Otherness. In Still Born (Sandzén, 2014), ultrasound footage is fused with digital film and animation to manifest the merging perspectives of a mourning mother and her aborted child.
A INDICAÇÃO GEOGRÁFICA (IG) SOB O PONTO DE VISTA GEOGRÁFICO PARA O QUEIJO DE COALHO DO AGRESTE DE PERNAMBUCO
Authors: Bezerra Janieire Dorlamis Cordeiro , Nascimento Júnior José Ribamar Silva do
Published: February 2017

Este tema, indicação geográfica (IG), embora possua relação intrínseca com o espaço e a organização do mesmo, é pouco estudado na geografia. Para que a IG se torne ferramenta para promover o desenvolvimento territorial deverá esta ser atrelada a uma política não só econômica, mas social e ambiental, procurando atingir os produtores marginalizados, a fim de evitar sua exclusão social. A IG do queijo de coalho do Agreste de Pernambuco é de indicação de procedência (IP) a qual contribuirá nas mudanças espaciais. Até a obtenção da certificação, serão necessários estudos que contribuam na obtenção da IG. Após a certificação serão extremamente necessárias outras pesquisas para poder gerenciar o processo de certificação e inclusão da agricultura familiar, podendo assim concluir que a IG do queijo de coalho do Agreste de Pernambuco de fato incluiu o agricultor familiar, valorizando sua produção, melhorando sua renda e possibilitando ascensão. Portanto, a certificação trará, além do reconhecimento da região, uma mudança sócio-espacial, que envolverá futuramente estudos com indicadores socioeconômicos, apresentando a interação do homem com o território, a forma de apropriá-lo e utilizá-lo, contextualizando as modificações espaciais.
Mechanism of Fatigue Crack Growth of Bridge Steel Structures
Authors: Zhu H.
Published: February 2017

This study was carried out on the background of Sutong Bridge project based on fracture mechanics, aiming at analyzing the growth mechanism of fatigue cracks of a bridge under the load of vehicles. Stress intensity factor (SIF) can be calculated by various methods. Three steel plates with different kinds of cracks were taken as the samples in this study. With the combination of finite element analysis software ABAQUS and the J integral method, SIF values of the samples were calculated. After that, the extended finite element method in the simulation of fatigue crack growth was introduced, and the simulation of crack growth paths under different external loads was analyzed. At last, we took a partial model from the Sutong Bridge and supposed its two dangerous parts already had fine cracks; then simulative vehicle load was added onto the U-rib to predict crack growth paths using the extended finite element method.
An Analysis of Snow and Wind Loads Combinations Based on Meteorological Data
Authors: Żurański J. A. , Sobolewski A.
Published: February 2017

The objective of this paper is to present a probabilistic method of analyzing the combinations of snow and wind loads using meteorological data and to determine their combination factors. Calculations are based on data measured at twelve Polish meteorological stations operated by the Institute for Meteorology and Water Management. Data provided are from the years 1966 - 2010. Five combinations of snow load and 10-minute mean wind velocity pressure have been considered. Gumbel probability distribution has been used to fit the empirical distributions of the data. As a result, the interdependence between wind velocity pressure and snow load on the ground for a return period of 50 years has been provided, and the values of the combination factors for snow loads and wind actions are proposed.
‘Achieved without Ambiguity?’ Memorializing Victimhood in Belgrade after the 1999 NATO Bombing
Authors: Bădescu Gruia
Published: February 2017

This paper examines the memory and narratives of the 1999 NATO bombings through a spatial lens, discussing how the debates surrounding memorial architecture reflect the multiple, and at times conflicting, understandings of the NATO bombing. By analysing the competition to reconstruct Radio Television of Serbia (RTS) from its ruins, this article discusses the tensions and challenges brought by narratives representing victimhood in Belgrade after 1999. It examines how understandings of victimhood have been spatialized through urban memorials, situating the RTS competition in the wider landscape of memorial representations of the NATO bombing in Serbia. Developed using a bottom-up process, the competition for the RTS memorial reflects both the opportunities and the limits of memorial architecture. While the competition and overall debates mirror general trends of memorial architecture in the context of European politics of regret and trauma, the limited scope of the memorial and its marginality in the cityscape both reflect and enhance the continuing obfuscation of the past in Serbia.
Cuando decir Napoleón III significaba decir Hitler. Los biopics de Dieterle y Muni (1935-1939)
Authors: Sánchez Menchero Mauricio
Published: February 2017

ResumenLa productora de cine Warner Brothers se encargó de la creación de tres biopics sobre la vida de Louis Pasteur, Benito Juárez y Emile Zola. Esta trilogía producida durante los años previos de la Segunda Guerra Mundial, se convirtió en un material de propaganda antinazi a pesar de la presión en contra del gobierno alemán en Estados Unidos y gracias a la astucia de dos artistas de origen judío en Hollywood como lo fueron el actor Paul Muni y el director William Dieterle.
"El artificio de los alquimistas". Notas sobre La gaya ciencia, de Nietzsche.
Authors: Castilla Cerezo Antonio
Published: February 2017

Asumiendo, por un lado, que como dijo Giorgio Colli La gaya ciencia es el momento central de la vida de Nietzsche y, por otro, que en ese libro el filósofo alemán es particularmente cuidadoso con la elección de los títulos, este artículo se propone analizar la relación existente en dicha obra entre los términos que vincula implícitamente el título de la misma, a saber: la ciencia y la alegría. Para ello recurre, además de a ciertos momentos estratégicos del texto publicado por Nietzsche, a diversos pasajes extraídos de su correspondencia y de sus escritos póstumos, así como a las aportaciones de pensadores posteriores (tales como Michel Foucault o el mismo Giorgio Colli) que reflexionaron sobre la mencionada conexión.
Reseña Sáez A., Hugo Enrique. Ejercicios de filosofía sobre educación. Una lectura de Heidegger. Colección Teoría y Análisis
Authors: Sánchez Antonio
Published: February 2017

Dentro de la amplísima gama de textos que ha suscitado el filósofo alemán Martin Heidegger en nuestra lengua aparece este interesante texto en el año 2013 fruto de la reflexión de Hugo Enrique Sáez A. Valdría la pena preguntarse, a estas alturas, qué puede haber en dicho texto que enriquezca la presencia del pensador alemán en el pensamiento filosófico contemporáneo en español.
Random Lasers Based on Organic-Inorganic Hybrids
Authors: Giannelis E.P. , Stasinopoulos A. , Psyllaki M. , Zacharakis G. , Das R. N. , Anglos D. , Anastasiadis S.H. , Vaia R.A.
Published: February 2017

Laser action is demonstrated in organic/inorganic nanocomposites consisting of pristine and surface-modified ZnO nanoparticles dispersed in an optically inert polymer matrix. The semiconductor particles feature simultaneously gain behavior and strong scattering ability, whereas the polymer matrix provides better processability and mechanical robustness. When excited by a laser pulse of appropriately short duration (pico- to nanoseconds), the composites give off fluorescence emission, which is strongly amplified as a result of light trapping due to multiple scattering. This laser action is manifested as a dramatic increase in the emitted light intensity accompanied by a significant spectral and temporal narrowing above a threshold value of the pumping laser intensity. Applications may include brighter flat-panel displays, inexpensive lasers for communications, military countermeasures, and lasers for search and rescue operations.
Incorporation of Rare-Earth Complexes in α-Zirconium Phosphate Layered Matrices via Pendant Amino Groups
Authors: Tlemsani Shanez , Franville Anne-Christine , Zambon Daniel , Mahiou Rachid
Published: February 2017

Amino-substituted rare-earth complexes (p-LnNH2DBM and m-LnNH2DBM with Ln3+ = Eu3+, Y3+) are intercalated in the interlayer region of a α-zirconium phosphate lattice to give luminescent hybrid lamellar materials. The preparation of the organic precursors and of the derived organic-inorganic materials is reported. XRD studies show that the hybrid compounds retain a layered structure and FTIR spectroscopy is used to monitor the intercalation reaction. The acid/base interactions between the NH2 functions and the pendant P-OH groups induce an important blue-shift of the absorption maximum of the organic molecule. The Eu3+ luminescence properties are investigated before and after intercalation of the organic complexes in the α-ZrP host structure and the optical characteristics of the para and meta derivatives are also compared.
A Generic Synthesis Route for Matrix Assisted Self-Assembly of Metal-Oxo Clusters in Organosilica Sol-Gels
Authors: Rao Mukti S. , Dave Bakul C.
Published: February 2017

The use of an organically modified silica sol-gel matrix containing ligating groups that assist in the formation of metal-oxo clusters is described. The metal-ligand interactions can be tuned by change in external environment such that: a) under overload metal ion concentrations, the sol-gel matrix sequesters the metal ions to promote the growth of 4-7 nm size metal-oxo clusters within the porous structure of the matrix, b) a change in pH releases the metal ions from the bound metal-oxo clusters, thereby making the sol-gel matrix behave as ferritin analogues. These characteristics of the matrix assisted self-assembly of metal-oxo clusters are shown using UVVis, TEM, AES, and EDX data.
Non-Local Elasticity Kernels Extracted from Atomistic Simulations
Authors: Picu R.C.
Published: February 2017

Non-local elasticity kernels are calibrated based on the atomic scale structure of glasses obtained from atomistic simulations. A model Morse material, with interatomic interactions described by a pair potential, and Al, characterized by an embedded-atom potential are considered. The study is limited to linear isotropic non-local elasticity. The functional form of the derived kernels is significantly different than that usually assumed in non-local constitutive models (Gaussian). They have a range that extends up to the cut-off radius of the interatomic potential, are positive at the origin, and become negative approximately one atomic distance away. These kernels involve 2 internal length scales that are both derived from atomistics for the materials mentioned above. The kernel for Al is tensorial, a different function weighting each entry of the stiffness tensor. Model materials interacting by pair potentials may be described by a single function that weights the whole stiffness tensor. Two applications are briefly described in closure. The new non-local model improves upon the Gaussian one by predicting a more realistic wave dispersion relationship, with essentially zero group velocity at the boundary of the Brillouin zone. Next, the role of non-locality in defining the Peierls stress of a dislocation is studied within a Peierls-Nabarro model and it is shown that the predictions of the critical stress improve upon consideration of non-locality.
Computer Simulation Studies of Fracture in Vitreous Silica
Authors: Ochoa Romulo , Arief Michael , Simmons Joseph H.
Published: February 2017

We conduct molecular dynamics computer simulations of fracture in silica glass using the van Beest, Kramer, and van Santen model. Stress is applied by uniaxial strain at different pulling rates. Comparisons with previous fracture simulations of silica that used the Soules force function are presented. We find that in both models stress is relieved by rotation of the (SiO4)-2 tetrahedrons, increasing Si-O-Si bonding angles, and only small changes in the tetrahedron dimensions and O-Si-O angles.