bluuebunny/crossref_metadata_2025 huggingface dataset:
Komunikasi Pemasaran Hotel seiring bertumbuhnya Homestay Daring: Kasus Hotel Berbintang di Jawa
Authors: Ardani Edvi Gracia , Basalamah Anwar
Published: February 2023

Pada era informasi abad ke-21saat ini, bermunculan berbagai platform peer-to-peer, yang secara kolektif dikenal juga sebagai platform-based economy atau ekonomi berbasis platform, yang sekarang dimanfaatkan oleh banyak kalangan di seluruh dunia terutama untuk industry akomodasi dalam bentuk homestay berbasis dalam jaringan atau daring. Bagi khalayaknya, platform ini memberikan kemudahan akomodasi untuk berwisata ke daerah yang menarik untuk dieksplorasi terutama untuk wisata rural. Sebagai penyedia jasa akomodasi, tentunya kompetisi dengan hotel-hotel yang bersifat komersil sangat kuat. Fenomena yang ada di berbagai negara di dunia menunjukkan, platform ini menjadi ancaman untuk para pengelola hotel yang tentunya menyediakan kamar dengan harga yang lebih tinggi dari homestay berbasis daring. Dampaknya tentu tidak hanya pada strategi penjualan, melainkan juga pada strategi komunikasi. Ancaman platform tersebut menjadi disruptif di mana ancaman ini dapat mengubah pola pengelolaan bisnis akomodasi karena aturan yang berbeda dan dapat membuat para pengelola hotel berpikir keras untuk mengubah strategi komunikasi hotel mereka atau tidak sama sekali. Ketersediaan platform bebas biaya dalam rantai jaringan hotel memberikan harapan bagi para pengelola hotel untuk mengeksplorasi kemungkinan dan mengantisipasi disrupsi yang dirasakan.
Pengaruh Telemarketing dalam Kegiatan Business Matching dalam Pameran Indonesia Maritime Expo 2019
Authors: Pertiwi Prita Indah , Akbar Djuni
Published: February 2023

Industri MICE (Meeting, Insentif, Conference, dan Exhibitions) adalah salah satu sektor jangka pendek dalam industri pariwisata yang secara ekonomis penting bagi pariwisata. Kegiatan marketing sangat berperan dalam memasarkan event MICE. Salah satu bagian dari marketing ialah kegiatan telemarketing. Dalam pameran B2B memiliki kegiatan yang wajib yaitu kegiatan Business Matching. Business Matching adalah sebuah pertemuan bisnis yang terjadwal antara pebisnis, pengecer, agen, distributor dengan calon investor atau partner. Pameran Indonesia Maritime Expo 2019 adalah pameran business to business (B2B) yang berskala international. Penelitian ini merupakan penelitian yang bersifat kuantitatif. Metode sampling yang di gunakan adalah Metode Sampling Purprosive. Pengambilan sampel berdasarkan seleksi khusus yang sesuai dengan kriteria yang di berikan. Tujuanpenelitain ini dimaksudkan untuk mengetahui pengaruh kegiatan telemarketing sebagai salah satu kegiatan marketing pada event pameran internasional. Kegiatan telemarketing dapat mempengaruhi potensial buyer dalam meyakinkan dan memutuskan untuk melakukan business matching. Kegiatan telemarketing juga dapat memberikan informasi yang lebih detail kepada potensial buyer untuk menciptakan peluang bisnis baru dengan calon rekan kerja.
Model Event Planning dalam Penyelenggaraan Training Masa Persiapan Pensiun oleh PT Arga Nusa Persada
Authors: Silmi Rana Mustika , Kongrat Etty
Published: February 2023

Mengikuti proses perencanaan event dapat membantu penyelenggara untuk membuat sebuah event yang sukses. Model perencanaan event digunakan sebagai framework sistematis yang terdiri dari beberapa tahapan. Penelitian ini dilakukan di PT Arga Nusa Persada, sebagai penyelenggara pelatihan Masa Persiapan Pensiun. Tujuan dari penelitian ini adalah untuk mengetahui model perencanaan event dari penyelenggara sebagai pemimpin dari pangsa pasar pelatihan Masa Persiapan Pensiun di Indonesia. Data yang digunakan di dalam penelitian ini merupakan data kualitatif. Data dikumpulkan dari observasi dan wawancara terstruktur dengan PT Arga Nusa Persada. Data ini kemudian ditulis menggunakan metode deskriptif. Berdasarkan hasil dari penelitian ditemukanlah model perencanaan event yang digunakan sangat membantu penyelenggara dalam membuat sebuah event pelatihan yang sukses, tahapan dari model event planning yang dilakukan yaitu : pengambilan keputusan awal, perencanaan yang rinci, implementasi dan evaluasi.
Efficacy of epinephrine rinse in allergen immunotherapy with aeroallergen and venom
Authors: Daniels Phuong , Valencia Reimus , Callahan Meghan , Hostoffer Robert
Published: February 2023

Introduction

In a suburban allergy outpatient office, the practice of epinephrine rinse of subcutaneous allergen immunotherapy (SCIT) syringes prior to injection has been employed for over 30 years with documented favorable clinical outcomes. A retrospective study was conducted to explore the effectiveness of epinephrine rinsing of SCIT syringes in managing local site reactions (LSR) in patients with allergen hypersensitivity.

Methods

Chart review of patients currently receiving SCITs was conducted using the clinical database at the outpatient office. 549 SCITs were reviewed, and 140 cases were traced to employ the use of epinephrine rinse to improve LSRs. The data was separated into allergic rhinitis and venom immunotherapy groups and was recorded for both build-up and maintenance phases.

Results

Out of 140 total patients requiring epinephrine rinse, 88.6% were in the allergic rhinitis group and 11.4% were in the venom group. In the allergic rhinitis group, 69.3% of patients and 87.5% in the venom group required epinephrine rinse during the build-up phase. In the allergic rhinitis group, 65.7% patients receiving SCIT at maintenance dose and 69.8% patients at build-up dose had resolution of LSR post-epinephrine rinse. In the venom group, 64.2% patients receiving SCITs at build-up dose improved LSR after epinephrine rinse.

Conclusion

Epinephrine rinse technique prior to injection showed favorable outcomes in over 60% of patients currently receiving treatment for allergen hypersensitivity. Epinephrine rinse is beneficial during the build-up phase of SCIT to manage LSR to effectively increase allergen dose.
The relationship between osteopathic manipulative treatment and focused breath work: A pilot study
Authors: Blevins Ryan , Doles Bethany , Buck Justin , Blevins Suzanne , Babos Marybeth , Taylor Courtney , Baines-Waiz Omari , Bergman Stephen
Published: February 2023

Introduction

According to osteopathic principles, structure and function of the human body directly influence one another. ‘Somatic dysfunction’ is known as altered or impaired function of related components of the somatic system; skeletal, arthrodial, myofascial, vascular, neural, and lymphatic. Osteopathic Manipulative Treatment (OMT) is the manual procedure utilized to treat somatic dysfunction. Focused breath work increases patient’s awareness of their breath. Altered breathing patterns are part of the constellation of somatic dysfunction within a patient. This study is designed to consider the effect of the sample size on the statistical significance for further study investigation while comparing the impact of OMT and focused breath work on somatic dysfunction.

Methods

This crossover trial included 35 participants from a pool of healthcare professional students. Participants were assigned to one of three groups. All groups were assessed for somatic dysfunction (SD), Thoracoabdominal Range of Motion (TROM), and Peak Expiratory Flow (PF) in each session. Each group followed a separate protocol for two weeks: either generalized osteopathic treatment (GOT), breathing exercise (BE) to be completed three times per week, or both. All participants completed each protocol over a six-week period.

Results

Statistical significance was observed in the group that received both OMT (GOT) and BE revealing an estimated effect size for the intervention.

Conclusion

Based on these results, we can recommend that breathing exercises combined with OMT may reliably decrease the incidence of somatic dysfunction.
Rasgos básicos y factores de crecimiento de la economía de Marruecos
Authors: Fernández Méndez de Andés Javier
Published: February 2023

Marruecos es un país de desarrollo intermedio con varias fortalezas estructurales muy notorias. Su ubicación geográfica como sello del Mediterráneo le otorga un gran valor estratégico; la proximidad al mercado europeo permite al país capitalizar una importante renta de situación; su riqueza minera, especialmente las grandes reservas de fosfatos, sumada a unas condiciones muy favorables para la producción de energía de origen solar o eólico, aportan una amplia base de recursos naturales sobre la que puede construirse un importante sector industrial. Sin embargo, Marruecos no consigue alcanzar tasas de crecimiento elevadas y sostenidas que le permitan mejorar de manera significativa el nivel de vida de su población. El artículo se centra en algunos factores que pueden explicar este resultado, en particular, la notable infrautilización del factor trabajo y la escasa rentabilidad de la inversión, con un peso desproporcionado de la inversión pública.
Tánger y el norte de Marruecos: una región en crecimiento
Authors: Cámara Oficial de Comercio de España en Tánger CECIT
Published: February 2023

En el presente artículo se describen las principales estrategias, fortalezas y zonas que protagonizan el desarrollo económico del norte de Marruecos, al que unen profundos lazos humanos y la proximidad geográfica con España. En el texto se exponen con detalle los principales proyectos económicos de una región en plena expansión demográfica y de crecimiento, que ha sido objeto del impulso decidido de las autoridades marroquíes en los últimos años, y se atiende de manera especial a las oportunidades para los exportadores e inversores españoles. La región de Tánger-Tetuán-Alhucemas, en fin, es una realidad en expansión que ha apostado simultáneamente por las industrias del automóvil, aeronáutica, textil o la confección, y experimenta un rápido e importante desarrollo urbanístico y de infraestructuras, además de turístico.
Special Issues in Hospitality and Tourism Management Journals
Authors: Steinberg Reece , Boettcher Jennifer C.
Published: February 2023

The purpose of this paper is to develop insight into the scholarly communications trends in hospitality and tourism management by looking at the practice of publishing Special Issues in top-ranked hospitality and tourism management (HTM) academic journals: examining the relationship of Special Issues (SI) to journal impact as a measurement of quality, identifying some principal topics of SI, and the trend of publishing SI as monographs. 
Building Maps Using Monocular Image-feeds from Windshield-mounted Cameras in a Simulator Environment
Authors: Szántó Mátyás , Kobál Sándor , Vajta László , Horváth Viktor Győző , Lógó János Máté , Barsi Árpád
Published: February 2023

3-dimensional, accurate, and up-to-date maps are essential for vehicles with autonomous capabilities, whose functionality is made possible by machine learning-based algorithms. Since these solutions require a tremendous amount of data for parameter optimization, simulation-to-reality (Sim2Real) methods have been proven immensely useful for training data generation. For creating realistic models to be used for synthetic data generation, crowdsourcing techniques present a resource-efficient alternative. In this paper, we show that using the Carla simulation environment, a crowdsourcing model can be created that mimics a multi-agent data gathering and processing pipeline. We developed a solution that yields dense point clouds based on monocular images and location information gathered by individual data acquisition vehicles. Our method provides scene reconstructions using the robust Structure-from-Motion (SfM) solution of Colmap. Moreover, we introduce a solution for synthesizing dense ground truth point clouds originating from the Carla simulator using a simulated data acquisition pipeline. We compare the results of the Colmap reconstruction with the reference point cloud after aligning them using the iterative closest point algorithm. Our results show that a precise point cloud reconstruction was feasible with this crowdsourcing-based approach, with 54\% of the reconstructed points having an error under 0.05 m, and a weighted root mean square error of 0.0449 m for the entire point cloud.
Ausiàs March i la «Vita nuova» de Dante
Authors: Cabré Lluís
Published: February 2023

Aquest article argumenta que Ausiàs March va accedir a la Vita nuova íntegra, i que aquesta lectura fou determinant per a la concepció del cicle de 35 poesies adreçades a Llir entre cards (dona Teresa d’Híxar). S’hi analitzen amb detall la poesia XXIII de March i l’esment de Dante a la poesia XLV.

This article argues that Ausiàs March read the whole of Dante’s Vita nuova, and that such reading was crucial for him to conceive his 35 poems addressed to Llir entre cards (Dona Teresa d’Híxar) as a poetic cycle. March’s poem XXIII and his reference to Dante in poem XLV are minutely analyzed.
Update on current treatments for adult acute myeloid leukemia: to treat acute myeloid leukemia intensively or non-intensively? That is the question
Authors: Jaramillo Sonia , Schlenk Richard F.
Published: February 2023

For several decades, the treatment for acute myeloid leukemia (AML) has been a dichotomous choice between intensive chemotherapy strategies with curative intent and non-intensive options including supportive care. Patients’ age and fitness, as well as comorbidities, primarily influenced this choice. However, the therapeutic armamentarium is evolving, so that there are highly effective and increasingly specific drugs, fitting the mutational profile of a patient’s leukemia. There is now a spectrum of treatment options that are less intense and can be administered in an outpatient setting and to a substantial extent are equally or even more effective than standard intensive therapy. We are, therefore, witnessing a radical change in the treatment landscape of AML. In this review, we examine the current treatment options for patients with AML, considering the molecular spectrum of the disease on the background of patient-related factors.
Branding and Strategic Positioning For Enhanced Performance among Online-Based Companies: An Empirical Study on Airbnb
Authors: Morris Karithi Njilu
Published: February 2023

Airbnb has been known for extensive services in online home-sharing and promotion of travel and tour business. However, bearing to the increasingly changing environment and business trends across the globe, it is time for Airbnb to diversify and extend its services to other inter-related products. The proposed new product for Airbnb is development of online taxi service platform in the most toured areas and other upcoming markets. While Airbnb has recently relied on homeowners to rent out their cars to their clients, Airbnb can also go an extra mile and have its own taxi platform which can either be developed separately or integrated with the existing platform. Through the existing potential clients and homeowners at the Airbnb platform, the company will identify the most appropriate travel destinations to start the service. The company will market the service where local drivers can link up with the travellers and offer taxi services. With time, this service can be expanded to stand on its own brand and compete with other key players in the market like Uber. However, it is proposed that the service can be piloted by partnering with the existing online taxi service providers like Uber. The company will then start its own service after the reception of the piloted service. The main potential customers for this service will be the existing customers at Airbnb and other referrals as well as other customers from extensive marketing to be done on the service. The pricing strategy adopted for the service will be economy strategy where the costs of development and marketing will be minimized and the prices minimized as well so as to stand a chance to compete with the existing players.
Study of the Perturbation in Temperature Profile of an AGR Fuel Pin for Surface Roughness of Cladding by CFD Simulation in Ansys Fluent
Authors: Nishat Sadek Hossain , Farha Farhana Islam , Sahadath Md Hossain
Published: February 2023

The surface roughness of nuclear fuel cladding plays a crucial role in the thermal-hydraulic response of the Advanced Gas Cooled reactor (AGR). In the present work, the change in the temperature distribution from an isolated AGR fuel rod to primary coolant due to cladding roughness was studied by computational fluid dynamics (CFD) simulation in Ansys Fluent software. Square transverse ribs of the various pitch to height ratios _p / k_ were considered as the surface roughness. Radial temperature profiles from fuel to coolant were generated. Lower fuel temperature was found for the fuel rod with a rough cladding surface as compared to the smooth cladding surface. The peak fuel temperature was determined and found to decrease with decreasing values of _p / k_ . Temperature drop across the fuel and from fuel to coolant was also studied.
DUJASE Vol. 7(1) 9-15, 2022 (January)
Hydrocarbon Prospectivity of Surma Group in Sylhet Area in Context of Sequence Stratigraphy
Authors: Islam Fahim Md Sajjadul , Matin Mondol Md Abdul , Hossain Bhuiyan Md Anwar
Published: February 2023

This research focuses on studying the Surma Group sediments with an integrated approach of using wireline logs and 2D seismic data from Sylhet structure and outcrop analogy from the Zaflong-Tamabil-Jaintiapur area to explain the geological evolution in the context of sequence stratigraphic framework and its implications to identify the hidden potential of hydrocarbon traps that remains overlooked. The 'SYL-07' well logs divided the encountered sedimentary strata by sequence boundaries (SB) and flooding surfaces (FS) into an upper third-order Lowstand System Tract (3_LST), followed by the third-order Highstand System Tract (3_HST), and underlying third-order Transgressive System Tract (3_TST) which correspond to the Tipam, Boka Bil, and Bhuban formations, respectively. The 3_HST has further been subdivided into fourth-order sequences. Well-to-seismic ties helped in identifying the sequence boundaries in the regional context. Three new prospects in the nose and flank area of the Sylhet structure have been detected based on seismic attributes and log responses. Seismic sweetness attribute anomalies confirmed the existence of these prospects. Rigorous fieldworks provided nineteen facies and seven sets of sedimentary facies associations and helped to establish the sedimentological stacking patterns and corresponding depositional environments. About 2250m lithocolumn constructed from field data revealed four third-order sequence stratigraphic system tracts roughly corresponding to Renji (3_LST), Bhuban (3_TST), Boka Bil (3_HST), and Tipam (3_LST) formations in the bottom-up order, while the obtained facies associations aid in identifying four fourth-order sequences including fourth-order system tracts in the 3_HST. The lithologic column corresponds well with the seismic sections and validates the seismically interpreted third-order system tracts and fourth-order sequences. However, the high-frequency fourth-order system tracts can only be correlated with the log motif patterns due to sub-seismic resolution. The erosional remains of the fourth-order sequences in 3_HST, for instance, the coarsening upward shoreface and shelfal facies topped by transgressive shale, have yielded potential future drilling sites based on seismic attribute and log response analysis. The analogy of field data with well log and seismic data helped the overall evaluation of the hydrocarbon prospectivity of the area.
The Dhaka University Journal of Earth and Environmental Sciences, Vol. 11(1), 2022: 95-110
Density divergence and density convergence
Authors: Ghosh Malay , Sarker Partha
Published: February 2023

Divergence between two distributions has been of statistical interest for more than a century, beginning with Karl Pearson with his famous chisquare test. The paper revisits some of the well-known density divergence measures, and studies their interrelationship. In addition, it is demonstrated how Scheffe’s pointwise density convergence implies convergence of distributions, based on different divergence measures. 

Journal of Statistical Research 2022, Vol. 56, No. 1, pp. 1-10
Juego simbólico en el desarrollo de las habilidades de interacción social en niños de 5 años de dos Instituciones Educativas Públicas del distrito de Ate- Lima
Authors: Talavera-Sánchez Rousbell
Published: February 2023

El presente trabajo de investigación titulado “Juego simbólico en el desarrollo de las habilidades de interacción social en niños de 5 años, Lima 2021”, tiene como objetivo, determinar la incidencia del juego simbólico en las habilidades de interacción social en niños de 5 años. El enfoque fue cuantitativo, diseño no experimental, nivel explicativo. La muestra fue no probabilística, intencional, conformando un total de 90 niños y niñas matriculados en aulas de 5 años de educación inicial. Los instrumentos utilizados fueron, una guía de observación, de 16 ítems para medir el juego simbólico con Alpha de Cronbach 0,985; y un cuestionario de 24 ítems para medir las habilidades de Interacción Social, con Alpha de Cronbach 0,991; los instrumentos fueron validados por juicio de expertos con el calificativo de aplicable. Como resultado se obtuvo que, el modelo de ajuste indica la dependencia al asociarse el juego simbólico y las habilidades de interacción social. Y de acuerdo con los valores de Chi-cuadrado es 28,200 y p = ,000 < α se rechaza la hipótesis nula. Entonces, se afirma que el modelo explica en un 38,8% (Nagelkerke = 0,388) la variabilidad de las habilidades de interacción social.
Cell Differentiation Agent Formulations to Win the War on Cancer
Authors: Liau Ming C , Baker Linda Liau
Published: February 2023

Solution of cancer was obviously an important national interest for President Nixon to declare ‘War on Cancer” in 1971. Health professionals failed the challenge to put cancer away during the 5 years of intensive presidential support and in the following 46 years of exclusive medical support allocated to cancer. Cancer stem cells (CSCs) stood in the way to deny the success of cytotoxic agents, the choice of cancer establishments in the past, to put cancer away. Cancer arises due to wound not healing properly. Consequently, the process of wound healing is the most appropriate modality of cancer therapy. Cytotoxic agents creating wounds are apparently contra-indication on cancer therapy. Cytotoxic agents are, however, the most effective agents to eliminate the most outstanding feature of cancer, namely the perpetual replication of cancer cells (CCs). A critical mechanism of wound healing is the induction of terminal differentiation of progenitor stem cells (PSCs) which are the precursors of CSCs. Wound healing metabolites active as differentiation inducers (DIs) and differentiation helper inducers (DHIs) are required to direct the terminal differentiation of PSCs to heal the wound. Cell differentiation agent (CDA) formulations are preparations of wound healing metabolites most fit to take out PSCs and CSCs by directing these cells to undergo terminal differentiation, which are protected by drug resistance and anti-apoptosis mechanisms, thus unresponsive to cytotoxic agents. CDAs alone or in combination with cytotoxic agents become perfect drugs to take out both CCs and CSCs, and to restore the functionality of chemo-surveillance necessary to win the war on cancer.
Evolutionary Origins of ORL Disorders
Authors: Turaman Cem
Published: February 2023

It is understood that our ancestors gained a strong evolutionary selective advantage in shaping the vocal tract that allowing them speak more intelligibly. However, humans pay heavy prices for the uniqueness of vocal tracts configuration. We precariously swallow our mouthful in exchange for speaking clearly, and the second heavy price humans pay is sleep snoring. Their evolutionary cause is that the respiratory system deriving on the wrong side and too late from the alimentary system. The fact that our nasal septum is usually curved contributes to these disorders. The reason of this is that a few million years ago humans had to compromise from the width of the birth canal with their pelvis in order to stand upright. As for our children’s ears, their development resembles the evolution of hominoids and they are far from smooth.
Utilização da espécie Baccharis sylvestris por indígenas da etnia Pankararu: das práticas tradicionais às perspectivas farmacológicas – uma breve revisão
Authors: Souza Pedro Henrique Nogueira de , Ferreira Magda Rhayanny Assunção , Soares Luiz Alberto Lira
Published: February 2023

Historicamente, o conhecimento tradicional tem sido ponto de partida para pesquisas inovadoras na área de medicamentos. Contudo, o potencial etnofarmacológico relacionado ao uso de algumas espécies, como alecrim-de-caboclo pelo povo Pankararu segue ignorado pela comunidade científica. Diante do exposto, esse artigo teve como objetivo realizar a compilação de estudos que relatem a utilização do alecrim-de-caboclo pelos indígenas da etnia Pankararu, especulando suas potencialidades farmacológicas baseada nos conhecimentos tradicionais. Foi realizada revisão da literatura nas bases de dados PubMed, Scielo e Google Acadêmico. Apenas 13 artigos foram considerados relevantes para o presente estudo, sendo 10 diretamente relacionados com o uso tradicional do alecrim-de-caboclo pelo povo Pankararu; e 3 relacionados a divergências na classificação botânica da espécie em outros contextos étnicos. Em 10 trabalhos foram relatados o uso tradicional do alecrim-de-caboclo para fins ritualísticos (80% dos estudos); além de uso medicinal (70% dos trabalhos). Apesar de não serem descritas as indicações terapêuticas, a utilização na forma de lambedor sugere indicação tradicional para gripes e resfriados. Dos 10 estudos, apenas 2 identificaram a espécie utilizada pelos indígenas Pankararu como Baccharis sylvestris. Outros 3 trabalhos, realizados em outros contextos étnicos, identificaram o alecrim-de-caboclo como Lippia thymoides ou Turnera diffusa. Estudos complementares precisam ser conduzidos no intuito de realizar uma descrição etnofarmacológica mais detalhada do alecrim-de-caboclo no contexto do povo Pankararu, incluindo indicações tradicionais, confirmação taxonômica, caracterização fitoquímica, estudos de toxicidade, além da investigação de potenciais farmacológicos.
Aspectos moleculares do carcinoma papilífero de tireoide
Authors: Mendes Ana Cristina Carneiro , Viegas Larissa Carvalho , Danziger Leila Rodrigues , Gomes Eriston Vieira
Published: February 2023

Introdução: O câncer de tireoide apresenta-se como a neoplasia endócrina mais frequente. A patogênese do câncer de tireoide considera mutações conduzindo à progressão através de um processo de desdiferenciação gerando carcinomas bem diferenciados, como papilar e folicular, e progredindo para carcinomas de tireoide pouco diferenciados, indiferenciados ou anaplásicos. Objetivo: Descrever as principais alterações moleculares para o desenvolvimento do CPT. Metodologia: Trata-se de uma revisão narrativa. Foram utilizadas as bases de dados, PUBMED, SCIELO, Science Direct, Google Acadêmico e Instituto Nacional de Câncer. Como critério de inclusão/exclusão, foram utilizados artigos compreendidos entre 2004 e 2022, nas línguas portuguesa e inglesa. Resultados e discussão: As alterações moleculares do PTC, surgem pela mutação inicial em algum gene envolvido na regulação de proliferação e/ou na diferenciação celular, levando a expansão clonal da célula geneticamente modificada devido a sua capacidade de proliferação e escape ao controle do ciclo celular através de alterações em genes, tais como, BRAF, KRAS, NTRK1 e RET. Conclusão: O início e a progressão do câncer de tireoide compreendem múltiplas alterações genéticas, das quais as mutações que levam à ativação das vias de sinalização MAPK e PI3K-AKT. Os genes alterados que afetam esta via incluem mutações nos genes que codificam transdutores de sinal intracelulares RAS e BRAF e rearranjos nos receptores tirosina quinase RET/PTC. Esses dados são de suma importância para a compreensão do mecanismo fisiopatológico desta condição, bem como oferecem a base para um diagnóstico mais assertivo e tratamento mais específico, propiciando um prognóstico mais favorável e com menos efeitos colaterais.
Perfil de vendas e de notificações de suspeitas de eventos adversos relacionados a hidroxicloroquina e a cloroquina durante a pandemia da COVID-19
Authors: Martins Nathalia Oliveira , Neves Carina de Morais , Rezende Cristiane de Paula
Published: February 2023

O presente trabalho teve como objetivo descrever o perfil de vendas de hidroxicloroquina e de notificações de suspeitas de eventos adversos relacionados à cloroquina e à hidroxicloroquina durante a pandemia da COVID-19. Trata-se de um estudo descritivo que utilizou dados extraídos do Painel de vendas de medicamentos industrializados e do Painel de notificações de farmacovigilância. Foram vendidas 1.862.978 caixas de hidroxicloroquina entre 01/04/2020 a 31/08/2021, sendo que em média 109.586 caixas foram vendidas por mês (mediana=110.318; mínimo=72.042; máximo=187.752). Em relação às notificações, foram realizadas 1.064 notificações que envolviam cloroquina ou hidroxicloroquina entre 01/03/2020 a 31/08/2021. Mais da metade delas (n=617;57,8%) foram documentadas até junho de 2020, enquanto que apenas 40 foram registradas entre janeiro a agosto de 2021. Esses achados estão condizentes com as evidências científicas, visto que estudos in vitro e preliminares, publicados no início da pandemia, encontraram resultados promissores a respeito do uso desses medicamentos. Contudo, em meados de 2020, estudos mais robustos apontaram que esses agentes não eram eficazes para tratar nem prevenir a COVID-19, além de serem pouco seguros para o paciente. Diante disso, certamente, declinou-se o uso desses medicamentos em hospitais brasileiros. Tal fato justifica a redução do número de notificações envolvendo esses medicamentos, uma vez que a detecção e notificação de eventos adversos, frequentemente, ocorrem no âmbito hospitalar, onde o paciente é monitorado constantemente. Porém, o perfil de vendas se manteve elevado durante o período avaliado. Isso denota o quanto que o incentivo social e político influenciou os brasileiros a usarem esses medicamentos.
Influência do nível de atividade física no índice de massa corporal e mudança de hábitos alimentares em universitários da região norte do brasil durante a pandemia da COVID-19
Authors: Travassos Maria Railane Ribeiro , Silva Thiago Renan da Silva e , Guariglia Débora Alves , Domingues Wagner Jorge Ribeiro
Published: February 2023

Objetivo: Verificar a influência do nível de atividade física (NAF) no índice de massa corporal (IMC) e nos hábitos alimentares em estudantes universitários durante a Pandemia da COVID-19. Métodos: Trata-se de um estudo transversal, por meio de questionário on-line com estudantes universitários da região norte do Brasil de ambos os sexos (40,3% homens; 59,4% mulheres) com média de idade de 26,2 ± 8,6 anos, IMC (kg/m²) 25,1 ± 5,9, e foi obtido pela razão entre a massa corporal (kg) dividida pela estatura (m) elevada ao quadrado, auto relatado. A avaliação dos hábitos alimentares foi realizada por meio de questionário online, baseado na escala de avaliação da dieta de acordo com o Guia Alimentar da População Brasileira. Resultado: Os dados de hábitos demonstram que 28,3% nunca costumam levar algum alimento consigo para consumo ao longo do dia. Não foram encontradas associações significativas entre nível de atividade física (ativos 51,2% e não ativos 46,7%) e IMC (normal), P=0,444. Conclusão: Adicionalmente, apenas uma variável teve significância entre o Nível de atividade física e os hábitos alimentares (P = 0,033), para as demais variáveis não houve associação significativa (P>0,05).
Contribuições da enfermagem perioperatória para segurança do paciente na sala cirúrgica: uma revisão integrativa
Authors: Santos Wanderson Paiva dos , Wilk Mirce Meire Gonçalves de Souza
Published: February 2023

Objetivou-se identificar as contribuições da enfermagem perioperatória para segurança do paciente na sala cirúrgica. Métodos: Trata-se de uma revisão integrativa de literatura, utilizando a estratégia PICO para busca dos artigos. Resultados: A maior parte dos estudos apontou como principal contribuição da enfermagem perioperatória, a implementação do checklist da cirurgia segura. Outros autores apontam contribuições da enfermagem em parceria com os demais membros da equipe de saúde. As contribuições estão relacionadas ao preparo emocional do paciente durante a cirurgia; pausa perioperatória para melhorar o handoff e; intervenções de enfermagem em sala operatória para reduzir índices de infecção. Conclusão: O presente estudo evidenciou que a Enfermagem perioperatória contribui diretamente para segurança do paciente anestésico-cirúrgico através de intervenções gerenciais e assistenciais e, também, por meio de comunicação efetiva com a equipe multiprofissional. Ressalta-se a importância da realização de estudos empíricos que evidenciem as contribuições da enfermagem perioperatória para segurança do paciente no ambiente cirúrgico.
Los proyectos de inversión pública y su relación con el desarrollo de la actividad turística
Authors: Garcia-Ponce Sara H. , Rubin-Robles Alan M. , Calderon-Cahue Johny J. , Solorzano-Trujillo Anny C. , Ponciano-Anchante Nancy L. , Contreras-Yalan Aida , Janampa-Grados Alexander N.
Published: February 2023

El propósito fue comprender en qué medida los Proyecto de Inversión Pública realizados se relacionan en el desarrollo de las actividades turísticas en la Provincia de Huánuco - 2015. El método fue cuantitativa, aplicada, deductiva, de diseño no experimental- corte transversal, la muestra se conformó por 167 PIP de la zona estudio. Se tuvo en cuenta los siguientes instrumentos: las fichas de registros, referencia electrónica y la observación. La validación estadística se dio mediante el alfa de Cronbach, con 96 % de confiabilidad. Del total de PIP realizados, según el grado de evaluación de influencia del desarrollo del turismo, se presenta un grado bajo y medio. Del total de proyectos, según las evaluaciones del grado de influencia en el desarrollo del turismo, se obtuvo un grado medio y alto. Del total de proyectos ejecutados por los gobiernos locales, según la evaluación del grado de influencia en el desarrollo del turismo, tienen un grado medio y alto. Se concluye que los PIP influyen en el crecimiento de las actividades turísticas.
Nini Brunt, 1891-1984
Authors: Koster Cees
Published: February 2023

Wanneer Nini Brunt (1891-1984) in de tweede helft van de jaren zeventig twee boekjes met memoires over haar Haagse jeugd uitbrengt,1 wordt daar in de literaire pers veel aandacht aan besteed. Niet alleen wordt het opmerkelijke feit besproken dat zij de tachtig al ruim gepasseerd is, ook gaat de aandacht uit naar haar reputatie. Illustratief is de opmerking van Ab Visser in de Leeuwarder Courant: ‘Niet velen zullen de naam van Nini Brunt kennen. De bekendheid die zij geniet, dankt zij aan haar voortreffelijke vertaalwerk (o.m. van Franz Kafka)’ (Visser 1977). De huidige status van Nini Brunt als ‘vergeten vertaalster’ blijkt uit het feit dat zij in een aantal belangrijke naslagwerken wel genoemd wordt maar niet beschreven. In zowel de Digitale Bibliotheek der Nederlandse Letteren als de theaterencyclopedie van het Nederlands Theater Instituut is haar naam in de index opgenomen, maar is geen inhoudelijk lemma te vinden: haar naam is bekend, maar leidt niet tot een verhaal. Opmerkelijk is verder dat zij ontbreekt in het in 2018 verschenen boek 1001 vrouwen in de 20ste eeuw en vooralsnog in het Digitaal Vrouwenlexicon van Nederland (DVN). Maar hoe gaat dat met de conjunctuur van een reputatie? Wie vergeten is, moet ooit gekend zijn. De reputatie die Brunt als vertaalster heeft, of heeft gehad, is vooral verbonden met haar vertalingen van het grootste deel van het verzameld werk van Kafka en van Mrs Dalloway van Woolf. Deze vertalingen maken echter maar een klein deel uit van haar oeuvre. De actieve vertaalcarrière van Brunt beslaat een periode van ruim vijftig jaar. Haar eerst bekende vertaling dateert uit 1928 (ze was toen 37 jaar oud): Zeemans thuisvaart, van David Garnett, verschenen bij Stols in Maastricht, de eerste uitgave van haar laatste vertaling verscheen in 1980 (het jaar waarin zij 89 werd), bij uitgeverij Allert de Lange: De legende van de Heilige Drinker van de Duitse exilauteur Joseph Roth. Een voorlopige inventarisatie van haar vertaaloeuvre laat zien dat zij tussen deze twee vertalingen nog 64 andere heeft geproduceerd, maar vermoedelijk zijn het er aanzienlijk meer.2 Tot 1960 gaat het vooral om kinderboeken en detectives, met een enkel boek van meer gecanoniseerde auteurs. Vanaf 1960 vormt juist de laatste categorie de meerderheid.
Hive Mind Online: Collective Sensing in Times of Disinformation
Authors: Ho Shuyuan Mary , Nickerson Jeffrey , Zhang Qian
Published: February 2023

This study investigates the efficacy of collective sensing as a mechanism for unveiling disinformation in group interaction. Small group interactions were simulated to experiment on the effects of a group reaction to incentivized deceptive behavior when initiated by social influencers. We use multilevel modeling to examine the individual communication data nested within group interactions. The study advances the use of computational efficacy to support the supposition of collective sensing—by analyzing individual social actors’ communicative language and interaction within group contexts. Language-action cues as stigmergic signals were systemically extracted, compared and analyzed within groups as well as between groups. The results demonstrate that patterns of group communication become more concentrated and expressive after a social influencer becomes deceptive, even when the act of deception itself is not obvious to any individual. That is, individuals in the group characterize deceptive situations differently, but communication patterns depict the group’s ability to collectively sense deception from circulating disinformation. The study confirms our postulation of using collective sensing to detect deceptive influences in a group.
Hubungan Antara Aktifitas Fisik Terhadap Cardiorespiratory Fitness
Authors: Amanati Suci , Jaleha Boki
Published: February 2023

Salah satu faktor yang dapat berhubungan dengan daya tahan tubuh adalah Aktivitas Fisik. Aktivitas fisik adalah setiap gerakan tubuh yang dilakukan untuk meningkatkan pengeluaran tenaga/energi dan pembakaran energi. Apabila seseorang melakukan latihan fisik atau olah raga selama 30 menit setiap hari atau minimal 3-5 hari dalam seminggu dapat dikatakan dalam tingkatan yang cukup (Karim,2018). Jenis penelitian yang digunakan adalah penelitian analitik, dengan desain studi Cross Sectional yang bertujuan untuk mengetahui hubungan Aktivitas Fisik dan status gizi dengan Cardiorespiratory fitness, yang dapat dilihat dari keuesioner IPAq (International Aktivitas Fisik Questionarre) yang telah diisi oleh partisipan dan juga dipadukan dengan tes daya tahan/endurance test Harvard StepTest, Hasil penelitian menunjukkan bahwa ada hubungan antara aktifitas fisik terhadap tingkat kebugaran partisipan yang disimpulkan dari uji hubungan untuk hasil score Harvard step test menggunakan uji korelasi Pearson didapatkan hasil 0,691. Artinya besar korelasi atau hubungan antar variabel aktifitas fisik dengan cardiorespiratory fitness yang menunjukkan bahwa ada hubungan antara aktifitas fisik terhadap tingkat kebugaran.
Pengaruh Aquatic Exercise Therapy dan Lari Terhadap Cardiorespiratory Fitness Pada Remaja
Authors: Windiastoni Yoga Handita , Haritsah Nurul Fithriati
Published: February 2023

Presentase penduduk Indonesia yang dikategorikan beraktivitas fisik rendah sebanyak 29,9%  dari total seluruh penduduk pada tahun 2010, 31,9% laki-laki dan 27,9% perempuan. Dampak yang terjadi akibat penurunan aktivitas fisik seseorang yaitu meningkatnya resiko penyakit kardiovaskuler. Oleh karena itu, dibutuhkan cardiorespiratory fitness yang adekuat untuk  mengurangi resiko penyakit kardiovaskuler. Cardiorespiratory fitness adalah kemampuan tubuh mengantarkan oksigen ke otot selama latihan .Salah satu cara meningkatkan cardiorespiratory fitness adalah dengan menggunakan Aquatic Exercise Therapy dan Lari.  Metode penelitian yang digunakan yaitu penelitian kuantitatif dengan desain eksperimental pre-test and post-test two group design. Penelitian ini dilaksanakan pada bulan Oktober 2020. Pada Kelompok I didapatkan hasil p = 0,000 ( p < 0,05), disimpulkan  ada pengaruh latihan aquatic exercise therapy. Pada Kelompok II didapatkan hasil p = 0,000 ( p < 0,000),  disimpulkan  ada pengaruh latihan lari, kelompok yang mempunyai different mean lebih tinggi yaitu kelompok  aquatic exercise therapy dengan hasil 7,225. Ada pengaruh latihan aquatic exercise therapy terhadap cardiorespiratory fitness nilai p= 0,000 (p<0,005), (2) Ada pengaruh lari terhadap cardiorespiratory fitness  nilai p=0,000 (p<0,005), (3)  Aquatic exercise therapy lebih berpengaruh dibandingkan dengan lari dengan selisih mean kelompok I 7,22 dan kelompok II 2,94.
Hubungan antara Aktivitas Fisik dengan Tingkat VO2Maks pada Siswa Sekolah Menengah Atas
Authors: Munir Mutmainnah , Nur'amalia Riskah , Irianto Irianto
Published: February 2023

Kelompok remaja hingga dewasa muda (15 – 24 tahun) memiliki gaya hidup tidak aktif atau kurang melakukan aktivitas fisik yang dilihat dari jenis kelamin, perempuan memiliki presentase lebih besar dalam hal kurang melakukan aktivitas fisik. Volume Oksigen Maksimal (VO2Maks) dapat ditingkatkan dengan rutin melakukan aktivitas fisik. Penelitian ini bertujuan untuk mengetahui hubungan antara aktivitas fisik dengan tingkat VO2Maks pada siswa sekolah menengah atas Pondok Pesantren Putri Darul Istiqamah Maros. Penelitian ini merupakan penelitian deskriptif dengan pendekatan cross sectional dan metode purposive sampling. Subjek penelitian yakni Siswa SMA Pondok Pesantren Putri Darul Istiqamah Maros yang berusia kisaran 15 – 18 tahun. Jumlah responden dalam penelitian ini sebanyak 89 orang. Pengumpulan data dilakukan dengan cara pengambilan data primer melalui instrumen pengukuran aktivitas fisik dengan menggunakan parameter International Physical Activity Questionnaire (IPAQ) dan pengukuran tingkat VO2Maks menggunakan Cooper Test (Lari 2.4 KM). Hasil Penelitian setelah dilakukan uji normalitas Kolmogrov Smirnov diperoleh sebaran data tidak normal (p<0.05), kemudian dilakukan uji analisis hubungan (Spearman Rho) menunjukkan nilai signifikansi (p) kedua variabel sebesar (p<0.05) yang berarti bahwa terdapat hubungan yang signifikan dengan korelasi negatif antara variabel aktivitas fisik dengan tingkat VO2Maks (r= - 498). Hal ini menunjukkan bahwa apabila nilai aktivitas fisik tinggi dan nilai VO2Maks rendah maka didapatkan hasil yang baik.
Gambaran Perilaku Keluarga Pasien Pascastroke dalam Mencari Pengobatan pada Masa Covid-19 di Provinsi Sulawesi Selatan
Authors: R Ariqah Halim , Maulang Immanuel , Irianto Irianto
Published: February 2023

Kebijakan pemerintah dalam memutus mata rantai penularan Covid-19 di Indonesia menyebabkan terjadinya perubahan perilaku pasien pascastroke dalam mencari pengobatan di kalangan masyarakat. Penelitian ini bertujuan untuk mengetahui gambaran perilaku keluarga pasien pascastroke dalam mencari pengobatan pada masa pandemi Covid-19 di Provinsi Sulawesi Selatan. Jenis yang digunakan dalam penelitian ini adalah deskriptif kuantitatif dengan menggunakan pendekatan cross sectional. Populasi dalam penelitian ini yaitu keluarga pasien pascastroke dari bulan Maret 2020 – Juni 2022 yang pernah melakukan fisioterapi selama pandemi Covid-19 di Stroke Center RSKD Dadi Provinsi Sulsel dengan jumlah sampel sebanyak 58 orang (n=58). Pengumpulan data dilakukan dengan pengambilan data sekunder dan data primer melalui kuesioner perilaku keluarga pasien pascastroke dalam mencari pengobatan. Data yang terkumpul kemudian diolah menggunakan Microsoft Office Excel untuk melihat distribusi karakteristik responden, faktor genetik, pengetahuan, sikap, dan tindakan keluarga. Hasil dari penelitian ini adalah pasien pascatroke tidak memiliki riwayat stroke dari keluarga, memiliki pengetahuan, sikap, dan tindakan keluarga yang baik dalam mencari pengobatan pada masa Covid-19. Selain itu, perilaku keluarga pasien pascastroke didominasi oleh tindakan berobat ke fasilitas-fasilitas pengobatan modern (public medicine) pada masa Covid-19.
RELATIONSHIP OF DEPRESSION LEVEL ON QUALITY OF LIFE OF ELDERLY HYPERTENSION PATIENTS IN RW 03 DESA LIMBANGAN KEC. LIBANGAN KAB. KENDAL
Authors: Prianahatin Ari Loga , Retnaningsih Dwi
Published: February 2023

ABSTRACT

Background: Hypertension is still a health problem faced by the elderly which is basically quite complex. Health problems that usually arise, for example, are related to changes in the cardiovascular system, which if left unchecked will interfere with the function of other organs. So the issue arises when feelings of anxiety and depression are experienced by the elderly. This study aims to determine the level of depression on the quality of life of elderly people with hypertension.

Research Methods: The type of research used is the quantitative method, with a cross-sectional design where data collection for independent and dependent variables is carried out at the same time. The research instrument used was a questionnaire in which the questionnaire was not tested for validity because it had been tested for validity in the research of Roudhotul Auliyak and Chasanah. The research respondents consisted of 40 elderly people with hypertension who were taken using a total sampling technique. This research was conducted on 8-10 June 2021 in RW 03 Limbangan Village, Limbangan District, Kendal Regency. The test analysis method used is Rank Spearman.

Result: There is a relationship between the level of anxiety and depression and the quality of life of the elderly with hypertension in RW 03, Limbangan Village, Limbangan District, Kendal Regency. The results of the analysis using the Spearman rank correlation test regarding depression on the quality of life of elderly people with hypertension, p value = 0.001 means p value
ANALYSIS OF THE IMPLEMENTATION OF GOVERNMENT REGULATION NO. 33 OF 2012 CONCERNING EXCLUSIVE BREASTFEEDING IN THE WORKING AREA OF PUSKESMAS BANDARHARJO
Authors: Saputri Catrin Dewi , Maharani Chatila
Published: February 2023

Based on the health profile of Puskesmas Bandarharjo in 2019, exclusive breastfeeding for infants aged 0-6 months increased from 27% or 135 babies to 33.85% or 215 babies in 2018. Exclusive breastfeeding coverage for infants aged 0-6 months at Puskesmas Bandarhajo has not reached the target of the Semarang City Strategic Plan (65%). This study aims to determine the implementation of Government Regulation Number 33 of 2012 concerning Exclusive Breastfeeding at Puskesmas Bandarharjo. This qualitative study used a descriptive approach. The result showed that the number of human resources at Puskesmas Bandarharjo has been fulfilled. The source of the funds is BOK funds. The facilities and infrastructure are quite complete. The implementation of the government regulation at Puskesmas Bandarharjo has been going well and in accordance with the existing regulation. This puskesmas does not issue specific regulations related to the Exclusive Breastfeeding program. The implementation of the program is in accordance with the Government Regulation No. 33 of 2012 concerning breastfeeding education, the importance of early breastfeeding initiation, and prohibiting the promotion of formula milk. The coverage of exclusive breastfeeding in the working area of Puskesmas Bandarharjo has not met the national target, which is still at 65%. Puskesmas Bandarharjo is expected to be able to make policies for the Exclusive Breastfeeding program, provide additional financial support so that all relevant officers can attend breastfeeding counseling training, and add posters or leaflets about the importance of exclusive breastfeeding in every strategic spot in the working area of puskesmas.

Keywords: Implementation, Government Regulation, Exclusive Breastfeeding