bluuebunny/crossref_metadata_2025 huggingface dataset:
Hacia una libertad epistemológica latinoamericana: El valor de pensar diferente
Authors: Concha Zelada Renán , San Martín Sepúlveda Nelly
Published: September 2021

El presente ensayo aborda como punto de partida, el valor y riqueza que posee la diversidad cultural de comunidades indígenas en el contexto de aprendizaje y cómo este conocimiento ha sido invisibilizado por un currículum homogéneo que no proporciona espacios para valorar otras formas de pensar. Luego, se presenta un breve recorrido histórico sobre la colonización de los pueblos indígenas y afroamericanos y los efectos que generó en ella el pensamiento racional e incuestionable del europeo, el cual se caracterizó por ejercer una violencia intelectual hacia los conocimientos de la cultura latinoamericana; para finalizar con el rescate cultural que investigadores y académicos se proponen, a través de las líneas epistemológicas del sur.
Worth of Artificial Intelligence in the Epoch of Modern Livestock Farming: A Review
Authors: Aharwal Bhavna , Roy Biswajit , Meshram Somesh , Yadav Aayush
Published: September 2021

Artificial intelligence (AI) is a human intelligence in machine encountered daily and impacts our lives. It is expected that the use of such technology in the livestock industry will automate the livestock processes and easy to manage. Biometric identification plays a key role in artificial intelligence which shows the individual identity, helps in the process of insurance and claim leakages, continue monitoring of farm animal is essential can be done with new technologies. Infra red temperature measurement camera is the newly added technology with sensor system in (AI). It is a temperature measuring device in the form of electromagnetic waves and the infrared radiation intensity. AI system consists of agent, sensor, actuators and effectors which are connected to cloud. It helps in the detection of estrus, animal diseases, body condition score and various physiological parameters using video surveillance data collection method. Artificial neural network is a branch of artificial intelligence (AI) which is based on a collection of connected units or nodes called artificial neurons and stored in a central database system. Sustainable economic future of dairy farms and to achieve 100% compliance rate. Modern dairy farms uses robotic system to deliver vaccines, machine milking and measurement of feed as per individual performance of the animal. AI analyzes the animal origin food quality traceability method from farm to fork. AI helps in the complete mechanized animal husbandry right from the birth of animal to production and food product. The future of AI in animal sector is not predictable, but advantages and daily increasing demand of AI over other sector will ensure future in animal sector as well.
Protective Nest Design for Indian House Sparrow (Passer domesticus L.) - with Reference to Predation and Reuse
Authors: Mahesh Veera , Lanka Suseela
Published: September 2021

Background: The House Sparrow (Passer domesticus L.), is a human-commensal bird species, belonging to the order Passeriformes. The rapid changes in our lifestyle resulted in the decrease of this bird population during the past four decades. Among the various causes viz., lack of food resources, pollution pressure, indiscriminate usage of pesticides etc. Habitat loss is found to be one of the main threats for their rapid decline. Installation of artificial nest boxes was found to be the best alternatives for raising the bird population. Methods: Jangareddigudem of West Godavari district, Andhra Pradesh, India, was chosen as the study area. The nest boxes were designed by incorporating certain modifications to the basic model specified by British Trust of Ornithology. Installation of the nest boxes was initiated from an area with moderate food resources, located towards south-west edge of the town and was expanded in to other areas in a latitudinal wise towards north and south directions. Data was collected on a regular basis to study the occupancy of the nest boxes by the house sparrows. Result: The model designed was proved to be protective from predators and also well accepted by the public. Out of 570 nests that were installed in the study area, 550 nests were occupied and being used for breeding, that comes to around 97.6% occupancy indicating the suitability and protectiveness of this model. The sparrow population in the study area has been increased with a count of sparrows from few to 300+ sparrows at each roosting site (two roosting sites) by the end of 2020 by utilizing the nest boxes.
Titanium Elastic Nails for Distal Radius-ulna Fractures in Young Dogs
Authors: Sodhi Harmanpreet Singh , Kumar Ashwani , Anand Arun , Sangwan Vandana , Gupta Dhiraj Kumar
Published: September 2021

Background: Radius-ulna is the most frequently fractured bone of the pectoral limb in dogs with high predisposition to distal fractures. The smaller size of the distal fragment and open physis restrict the use of rigid fracture fixation techniques in distal fractures of growing dogs. Titanium elastic nails (TENs) are recommended in medical practice to stabilize long bone fractures in children. There is paucity of literature on TENs for the repair of radius-ulna fractures in dogs. Methods: This clinical study enrolled 10 dogs (7 grey hound and one each of Crossbred, Pomerenarian and Siberian Husky) suffering from distal radius-ulna (6 transverse and 4 short oblique) fractures since a mean±SD duration of 3.40±4.5 days. The mean±SD age and body weight of the dogs was 12.60±6.45 months and 14.09±6.41 kg, respectively. All except one fracture was stabilized with two TENs inserted into the medullary canal of radial bone in a normograde manner from distal to proximal end using open cranio-lateral surgical approach. Result: Majority fractures achieved satisfactory reduction (n=8), radiographically. Weight bearing scores on walking increased gradually from day 12 (1.62±1.51) to 45th (2.57±1.51), day 60th (3.75±0.5) and day 90 (4.0±0). Five dogs had uneventful recovery whereas remaining had major (n=2) or minor (n=3) complications. The length of the operated bone was non-significantly lesser as compared to contralateral healthy bone on day 60. Goniometric assessment of carpal joint of operated limb showed restricted range of motion on day 12 that improved to the near normal as contralateral healthy limb on day 60. Long-term results showed full (9) and acceptable (1) functional outcome. In conclusions, the TENs technique is simple and less invasive alternative fixation technique for distal radius-ulna fractures in young and light weighing dogs. As per authors, this is the first report on the use of TENs for the management of radius-ulna fracture in dogs.
El exilio y la ocupación foránea las dirime el verso. Selección de poesía. Nota preliminar Verso que germina en el exilio: miradas al tiempo en la poesía de Bahia Mahmud Awah
Authors:   Universidad Autónoma de Madrid, Spain, Awah Bahia Mahmud , Galindo Cossette ,   Universidad Iberoamericana, Mexico
Published: September 2021

This note introduces the selection of poems by the poet Bahia Mahmud Awah presented here. The intention is to raise the spatial aspects that the experience of exile imprints on the poet’s conception of the political role of poetry in other geographic latitudes, and also to note the temporal aspects of the history of the Saharawi people which motivate, in his poetry, an interpretation of the past, the present and the future.
GESTÃO DOS RESÍDUOS DA CONSTRUÇÃO CIVIL: ANÁLISE DA LEGISLAÇÃO MUNICIPAL DE GUANAMBI – BA
Authors: Leal Thomas Leonardo Marques de Castro , Silva Naiara De Lima , Araújo Luísa Magalhães
Published: September 2021

O setor da construção civil colabora positivamente com o crescimento econômico e geração de empregos diretos e indiretos. Todavia, o crescimento desse setor também gera passivos. Em virtude disso, tem crescido a preocupação com os resíduos de construção e demolição gerados, os quais são classificados de acordo com suas características, de modo a facilitar seu gerenciamento. O estudo busca analisar a legislação municipal de Guanambi que dispõe sobre o gerenciamento dos resíduos sólidos da construção civil, verificando sua adequação em relação à legislação nacional e como vem acontecendo a gestão dos resíduos no município. Para isso foram analisadas a legislação municipal, referente ao gerenciamento desses resíduos frente à sua prática, avaliada através de agentes envolvidos e observação de pontos de destinação final. Nota-se que as diretrizes impostas nas leis municipais não são suficientes para cumprir o que preconiza a Resolução Conama nº 307/2002 e a Política Nacional de Resíduos Sólidos, e nem suficiente para sensibilizar os geradores. Ademais, o Plano Municipal Integrado de Gestão de Resíduos Sólidos, ainda que inclua o Plano Municipal de Gerenciamento de Resíduos da Construção Civil em seu texto, não contempla os requisitos estabelecidos pela PNRS. Assim, as ações do poder público têm sido incipientes e o arcabouço legislativo tem um caráter mais normativo, não direcionando para o desempenho em prol de edificações de menor impacto ambiental.
AVALIAÇÃO DO POTENCIAL DE RECICLAGEM DOS RESÍDUOS SÓLIDOS URBANOS NA REGIÃO CENTRAL DO MUNICÍPIO DE ITACOATIARA/AM
Authors: Guimarães Gabriel Dos Anjos , Batista Mariana Medeiros
Published: September 2021

É evidente a necessidade de uma atenção diferenciada em relação ao gerenciamento dos resíduos sólidos no país. Entretanto, a grande maioria dos municípios utilizam um modelo de gerenciamento de resíduos sólidos ainda precário, realizando apenas a coleta dos resíduos, encaminhando-os diretamente, sem nenhum tipo de segregação ou coleta seletiva, à disposição final. Diante disso, este trabalho teve por objetivo avaliar o potencial de reciclagem dos resíduos sólidos urbanos em bairros da região central do município de Itacoatiara, no Amazonas. Para isso, foram realizadas duas caracterizações quali-quantitativas dos resíduos provenientes da área de estudo. Em cada amostragem, foi aplicado o método do quarteamento a fim de obter uma amostra final (600 L) para a determinação da composição gravimétrica. O quantitativo dos resíduos coletados foi obtido por meio da pesagem dos caminhões coletores. Além disso, entrou-se em contato com os atores envolvidos no mercado de materiais recicláveis do município, de forma a obter o valor de compra e venda dos mesmos. Diariamente são coletados cerca de 15 ton de resíduos na região de estudo, sendo que deste total, 51,32% representa o material orgânico, seguido de 37,40% de material reciclável, 6,36% dos demais resíduos e 4,93% de rejeitos. O ganho econômico estimado com a comercialização dos materiais passíveis de reciclagem pode chegar a R$ 764.755 por ano. Sendo assim, o presente estudo apresenta dados que mostram a importância da coleta seletiva na região, sendo uma forma de gerar renda e, ao mesmo tempo, contribuir para a redução do volume destes materiais no lixão.
Methodological Map as a New Element of the Diagnostic System of Personnel Training for Modern Economy
Authors: Kreer Mikhail , Skazochkina Tatiana , Skazochkin Aleksandr
Published: September 2021

The article is devoted to the analysis of the possibilities and the description of the methodological map, which is the Russian analogue of the “individual cell” of the student and has proven itself well in the United States. The methodological map reflects the static profile of the trainee’s abilities and, when periodically filled in, represents a dynamically developing trajectory of a professional orientation, regardless of the profile.At present, the general need of the economy for high-quality specialists based on the selection of students capable of mastering complex, high-tech technologies that have a clear potential for professional growth and personal development. At the same time, we can state the absence of a developed relationship between the education system and the vocational guidance system, which strategically can lead to problems in providing the most technologically advanced segments of the economy with professional staff. At the same time, thereis a positive international experience in solving this problem, the elements of which can be adapted to the existing Russian system.The article presents the content and describes the capabilities of the methodological map developed by the staff of the M.V. Lomonosov, and is an analogue of the “individual cell” developed in the United States. The methodological map is information about the level of several types of competence of any student. To work with such a card, the teacher needs to expand his competence and become an expert testologist with a sufficient level of test competence. An obvious advantage of the methodological map is the ease of its digital processing, the accumulation of information about the student in centralized databases. The methodological map, after appropriate modernization, can be the basic option for training highly qualified specialists who have chosen the path of a scientist. The development of such a diagnostic system has significant positive features, the most obvious of which is the ability to ensure the connection between the content of education and the personnel needs of society and the state, and, as a result, to ensure their sustainable socio-economic development.
Cognitive distortions as a subject of depiction in A. Green’s short prose: “Birk’s Story”
Authors:   Lomonosov Moscow State University, Zhang Rui
Published: September 2021

This article discusses the principles of psychologism in the early works of A. Green. The material for analysis is his “Birk’s Story” (1910), in which the realistic experience of describing human consciousness is combined with features of romantic psychopoetics. Lermontov’s traditions are indicated in the depiction of the protagonist’s psyche and his thinking. Focus is given to the specific features of the prose of from 1900 to 1910 with the display of the inner world of a person, namely, a modernist transformation of space, dissociation of the person, and the autonomy of consciousness. Later analyzed are the expressive details of the hero’s state before, during and after the failed suicide. A series of psychological techniques used by Green to create the image of a person in extraordinary circumstances are summarized: the motivation of illogical actions, the interconnection and sequence of mental impulses, the reflection of thoughts in reflection, the conflict of desire and logic, the introduction of an imaginary reality into the narrative, and the destruction of the effect of mystery. Two types of consciousness are correlated — the adequate and the pathological. The conclusion is made about the increased functionality of the image of consciousness in the plot and composition of “Birk’s Story”. The polemicity of the question about the degree of reliability and fiction of events are noted by Green. An assumption is made about their psychiatric basis — the image of such an ailment as a double orientation, which allows us to conclude that the narrative is quasi-fantastic.
Integração de atributos topográficos na aplicação de regressões logísticas no mapeamento digital de solos situados em relevos suaves na região noroeste paranaense
Authors: Nowatzki Alexei , José Cordeiro Santos Leonardo
Published: September 2021

A região noroeste do Paraná é composta por rochas sedimentares do grupo Caiuá, relevos pouco contrastados, clima tropical e ocorrência de Latossolos e Argissolos, que juntos representam mais de 50% dos solos existentes no território nacional. A associação solo-relevo nessa região dificulta o mapeamento pedológico tradicional, principalmente pela falta de parâmetros morfológicos em campo e em gabinete, que possam servir de base para delimitar essas classes de solos. Baseada na relação solo-relevo, o objetivo deste trabalho foi realizar um mapeamento digital de solos no baixo curso da bacia hidrográfica do rio Ivaí a partir da integração de atributos topográficos pelo método de regressões logísticas, buscando mapear as unidades de mapeamento Latossolo (UM-01) e Argissolo (UM-02). Os atributos selecionados para geração dos modelos foram: clinografia, índice de posição topográfica, índice de rugosidade do terreno, índice topográfico de umidade (modificado) e plano de curvatura. Os resultados indicaram uma maior distribuição da UM-01 no setor norte da bacia ao passo que a UM-02 foi mais expressiva no setor sul. No total da área de estudo, a unidade de mapeamento referente aos Latossolos representa 45,3%, enquanto dos Argissolos é de 54,7%. Este trabalho demonstrou que mesmo em regiões com predomínio de relevos pouco contrastados é possível atingir resultados confiáveis utilizando o mapeamento digital de solos.
Mapeamento Geomorfológico Regional Semiautomatizado por Descoberta e Modelagem do Conhecimento
Authors: Girão Raphael e Silva , Vicens Raúl Sanchez , De Almeida Julio Cesar Horta , Fernandes Pedro José Farias
Published: September 2021

O objetivo do presente estudo é a elaboração de um mapa geomorfológico do estado do Rio de Janeiro na escala 1:250.000, a partir do desenvolvimento de uma metodologia que envolva uma abordagem que minimize a subjetividade inerente à atividade de mapeamento geomorfológico, combinando diferentes dados quantitativos/qualitativos e utilizando procedimentos semiautomatizados de mapeamento. Para tal, foram utilizados um sistema de interpretação de imagens baseada em conhecimento e técnicas de descoberta de conhecimento em banco de dados - Knowledge Discovery in Databases (KDD). A partir desse estudo, conclui-se que: (i) a combinação da análise de imagens baseada em objetos geográficos (GEOBIA) com a KDD obteve bons resultados no mapeamento geomorfológico semiautomatizado, permitindo a utilização de uma grande diversidade dados quantitativos e qualitativos, e, ainda assim, minimizando as subjetividades envolvidas no mapeamento; (ii) apesar dos avanços tecnológicos e metodológicos, o conhecimento do especialista sobre o que está sendo mapeado continua sendo imprescindível, uma vez que as etapas que mais impactaram nos resultados obtidos no mapeamento são diretamente influenciadas por tais conhecimentos: a segmentação e a seleção do conjunto amostral.
Clinical and Pathogenetic Assessment of Relationships Between the Dynamics of Body Weight Changes and Atrial Fibrillation in Patients with Primary Obesity
Authors: Praskurnichiy E. A. , Morozova O. I.
Published: September 2021

Aims.To evaluate the impact of body weight dynamics on the clinical course of atrial fibrillation in obese patients.

Materials and methods. The study included 101 primary obese patients with paroxysmal or persistent atrial fibrillation. Study design: a retrospective, single-center, comparative study. Retrospectively аccording to the he body weight dynamics, patients were divided into 3 groups: those who increased their body weight by >3 % (Group 1, n=40), maintained their initial body weight by ±2.9 % (Group 2, n=29), and reduced their initial body weight by >3 % (Group 3, n=32). Follow-up examinations by a doctor were carried out at least once every 6 months for minimum 36 months. Change in AF type was determined by disease patterns and 7-day Holter monitoring results. The groups were comparable in gender (p=0,9267), age (p=0,3841), height (p=0,8900), and disease form (Paroxysmal atrial fibrillation /Persistent atrial fibrillation) (p=0,8826), the severity of symptoms on the European Heart Rhythm Association score of atrial fibrillations (p=0,8687) and systolic blood pressure at the beginning of the study (p=0,4500).

Results. At the final control examination, the body weight of patients in Group 1 increased by an average of 11,4 [9,3; 13,1] kg (р <0,001*), while weight loss in Group 3 averaged -6,2 [-8,4; -5,3] kg (p <0,001*). The decrease in body weight of Group 2 patients was insignificant (p=0,5377) and amounted to -0,1 [-2,0; 1,3] kg. The progression of the disease from paroxysmal to persistent form was observed among 15 (37 %) patients in Group 1, 9 (31 %) patients — in Group 2, 2 (6 %) patients — in Group 3 (p=0,0079*). The regression of arrhythmia from persistent to paroxysmal form was not registered in group 1 (0 %), in group 2, the reverse development of the disease was noted in 1 patient (3 %) and in group 3 — in 6 patients (19 %) (p=0,0053*). There were no free from AF patients in Group 1 at the final follow-up, while 2 (7 %) patients were free from AF in Group 2 and 7 (22 %) — in Group 3 (р=0,0047*). In patients undergoing ablation, procedural success was determined after a 3-month blind period. The need for interventional procedures to restore the sinus rhythm and their multiplicity when comparing the groups did not differ significantly. However, in a pairwise comparison, the difference between groups 1 and 3 of participants was statistically significant (p=0,0079* and p=0,0374*, respectively).

 Conclusion. This study demonstrates the relationships between the dynamics of body weight and the clinical course of atrial fibrillation. The progression of obesity leads to the progression of the disease. Weight-loss management reverses the type and natural progression of AF, improves the prognosis and the course of disease, regardless of other significant risk factors, increases the anti-arrhythmic therapy effect and the effect of interventional treatment.
Fraud triangle, misuse of information technology and student integrity toward the academic cheating of UM student during the pandemic Covid-19
Authors: Juliardi Dodik , Agung Sudarto Triadi , Taufiqi Rahmatullah at
Published: September 2021

There are many forms of academic cheating that occur among students, especially the practice of cheating. There are many factors that encourage students' academic cheating practices, especially with the aim of getting a targeted high score. Therefore, the researcher tries to find out the factors that influence the actions of academic cheating among students by referring to the fraud triangle theory which is relevant to the theme of this research. The variables observed in this study were: pressure (X1), opportunity (X2), rationalization (X3), misuse of information technology (X4), and student integrity (X5) as independent variables (independent), while the dependent variable (dependent) used behavior academic cheating on students (Y). This study used an instrument in the form of an open questionnaire with a Likert scale. The population that took as many as 500 accounting students, UM, and samples collected as many as 30 samples that have been filtered according to the criteria (purposive sampling). Analysis of the data used is multiple linear regression analysis. The results show that simultaneously, the variables of pressure, opportunity, rationalization, misuse of information technology, and student integrity have an influence on student academic fraud. The partial test shows that only the misuse of information technology has an effect on academic cheating of accounting students, ME, while the other variables have no significant effect. This is because when students learn online during the Covid-19 pandemic, they are able to take advantage of technological sophistication in this globalization era, especially in the current industry 4.0 era to carry out academic cheating actions that are oriented towards targeted values (GPA).
O rural civilizado: a experiência do hipismo no Jacarepaguá Tênis Clube (Rio de Janeiro; 1940-1957) = El rural civilizado: La experiencia de la hípica en el Jacarepaguá Tênis Clube (Rio de Janeiro; 1940-1957) = The civilized rural: The equestrian experience of Jacarepaguá Tênis Clube (Rio de Janeiro; 1940-1957)
Authors: De Melo Víctor Andrade
Published: September 2021

ResumoFundado em 1939, o Jacarepaguá Tênis Clube foi uma das únicas agremiações dos subúrbios cariocas a ter uma equipe de hipismo, modalidade usualmente praticada por gente de estrato socioeconômico alto. Este artigo tem por objetivo discutir essa experiência esportiva considerando que as iniciativas associativas são relevantes indicadores dos processos de urbanização, conformação de identidades e constituição do território. Adotou-se o recorte temporal de 1941 a 1957, período em que a equitação existiu no clube investigado. Como fontes, foram utilizados revistas e jornais publicados no Rio de Janeiro. Ao final, conclui-se que o incentivo ao esporte equestre foi mobilizado no sentido de forjar uma boa imagem para o clube, o apresentando como expressão do rural civilizado que caracterizaria o bairro. ResumenFundado en 1939, Jacarepaguá Tênis Clube fue uno de los únicos clubes de los suburbios de Río de Janeiro que contó con un equipo de hípica, modalidad que habitualmente practican personas de alto nivel socioeconómico. Este artículo tiene el objetivo de discutir, desde su repercusión pública, la experiencia de esta sociedad deportiva considerando que las iniciativas asociativas son indicadores relevantes de los procesos de urbanización, conformación de identidades y producción del espacio. Se adoptó el marco temporal de 1941 a 1957, período en el que existía la equitación en el club investigado. Como fuentes se utilizaron principalmente revistas y periódicos publicados en Río de Janeiro. Al final, se concluye que el incentivo al deporte ecuestre se movilizó con el fin de forjar una buena imagen para el club, presentándolo como una expresión de lo rural civilizado que caracterizaría al barrio. AbstractFounded in 1939, Jacarepaguá Tênis Clube was one of the only clubs in the suburbs of Rio de Janeiro that had a team of horse riding, a sport usually practiced by people from high socioeconomic strata. This article aims to discuss, from its public repercussion, the experience of this sports society considering that associative initiatives are important indicators of processes of the urbanization, formation of identities and space production. The time frame from 1941 to 1957 was adopted, a period in which horse riding existed in the investigated club. As sources, they were used mostly magazines and newspapers published in Rio de Janeiro. It is concluded that the incentive to equestrian sport was mobilized in order to build a good image for the club, presenting it as an expression of the civilized rural that would characterize the neighbourhood.
Functoriality of the Schmidt Construction
Authors: Climent Vidal Juan , Cosme Llópez Enric
Published: September 2021

After proving, in a purely categorial way, that the inclusion functor InAlg(Σ) from Alg(Σ), the category of many-sorted Σ-algebras, to PAlg(Σ), the category of many-sorted partial Σ-algebras, has a left adjoint FΣ, the (absolutely) free completion functor, we recall, in connection with the functor FΣ, the generalized recursion theorem of Schmidt, which we will also call the Schmidt construction. Next we define a category Cmpl(Σ), of Σ-completions, and prove that FΣ, labeled with its domain category and the unit of the adjunction of which it is a part, is a weakly initial object in it. Following this we associate to an ordered pair (α,f), where α=(K,γ,α) is a morphism of Σ-completions from F=(C,F,η) to G=(D,G,ρ) and f a homomorphism in D from the partial Σ-algebra A to the partial Σ-algebra B, a homomorphism ΥαG,0(f):Schα(f)B. We then prove that there exists an endofunctor, ΥαG,0, of Mortw(D), the twisted morphism category of D, thus showing the naturalness of the previous construction. Afterwards we prove that, for every Σ-completion G=(D,G,ρ), there exists a functor ΥG from the comma category (Cmpl(Σ)↓G) to End(Mortw(D)), the category of endofunctors of Mortw(D), such that ΥG,0, the object mapping of ΥG, sends a morphism of Σ-completion in Cmpl(Σ) with codomain G, to the endofunctor ΥαG,0.
Physical bases of Boron Neutron Capture Therapy, Dosimetry, and Its Mechanisms of Action - Critical Overview of the Literature
Authors: Skwierawska Dominika , Balcerzyk Marcin , Lopez-Valverde Jose Antonio , Leal Antonio
Published: September 2021

The success of boron neutron capture therapy(BNCT) mainly depends on sufficient spatial bio-distribution of boron(10B) localized around or within the neoplastic cells to produce a high dose gradient between the tumor and healthy tissue. Contrary to what is usual in radiotherapy, BNCT proposes treatment planning directed at the cell instead of the tumor mass. However, it is not yet possible to precisely determine the concentration of 10B in a specific tissue in real-time using non-invasive methods. Some critical issues still need to be resolved if BNCT is to become valuable, minimally invasive, and efficient cancer treatment. This review article provides an overview of fundamental principles, the recent advances, and future directions of BNCT as cellular targeted cancer therapy. The main emphasis is on topics related to biological dosimetry, methods for as-sessment of boron concentration, mechanisms of action of BNCT, and its physical bases for clinical implementation.
Honeypots for Internet of Things Research: An Effective Mitigation Tool
Authors: Xin En Shen , Si Ling Liu , Cheng Hao Fan
Published: September 2021

In recent years, due to their frequent use and widespread use, IoT (Internet of Things) devices have become an attractive target for hackers. As a result of their limited network resources and complex operating systems, they are vulnerable to attacks. Using a honeypot can, therefore, be a very effective way of detecting malicious requests and capturing samples of exploits. The purpose of this article is to introduce honeypots, the rise of IoT devices, and how they can be exploited by attackers. Various honeypot ecosystems will be investigated further for capturing and analyzing information from attacks against these IoT devices. As well as how to leverage proactive strategies in terms of IoT security, it will provide insights on the attack vectors present in most IoT systems, along with understanding attack patterns.
Immuno-Efficacy of Multi-Epitope Chimeric Peptides Against Foot and Mouth Disease Virus: Potential Vaccine Candidates for Newly Emerged Serotype O and A
Authors: AKTER SALMA , Rahman Md. Shaminur , Islam M. Rafiul , Akther Masuda , Marjia Mafruha , Rahman Md. Mizanur , Sultana Munawar , Hossain M. Anwar
Published: September 2021

Artificially designed, chimeric peptide-based recombinant vaccines are novel approaches to combat the phylogenetically diverse Foot and Mouth Disease (FMD) Virus (FMDV) strains. Among seven distinct serotypes, only serotype O and A are dominantly circulating in Bangladesh and neighbouring countries of Asia, where transboundary transmission, recurrent outbreaks and emergence of novel lineages FMDV are highly prevalent. The objective of this study was to develop multi-epitope recombinant peptides, procuring immunogenicity against circulating diverse subtypes of FMDV serotype O and A. Two chimeric peptides, named B1 (41.0 kDa) and B3 (39.3 kDa), have been designed to incorporate potential B-cell and T-cell epitopes selected from multiple FMDV strains, including previously reported and newly emerged sub-lineages. After expression, characterization and immunization of guineapigs with considerable antigen load of B1 and B3 followed by the serological assays revealed the significant protective immunogenicity, developed from the higher (100 µg) doses of both antigens, against most of the currently prevalent serotype O and A strains of FMDV. The efficient expression, antigenic stability, and multivalent immunogenic potency of the chimeric peptides strongly indicate their credibility as novel vaccine candidates for FMDV serotypes O and A circulating in Bangladesh and surrounding territories.
Exercising D. melanogaster Modulates the Mitochondrial Proteome and Physiology - The Effect on Lifespan Depends Upon Age and Sex
Authors: Ebanks Brad , Wang Ying , Katyal Gunjan , Sargent Chloe , Ingram Thomas L , Bowman Antonia , Moisoi Nicoleta , Chakrabarti Lisa
Published: September 2021

Ageing is a major risk factor for many of the most prevalent diseases, including neurodegenerative disease, cancer and heart disease. As the global population continues to age, behavioural interventions that can promote healthy ageing will improve quality of life and relieve the socio-economic burden that comes with an aged society. Exercise is recognised as an effective intervention against many diseases of ageing, but we don’t know the stage in an individual’s lifetime in which exercise is most effective at promoting healthy ageing and whether it has a direct effect on lifespan. We exercised w1118 Drosophila melanogaster, interrogating effects of sex and group size, at different stages of their lifetime and recorded their lifespan. Climbing scores at 30 days were measured to record differences in fitness in response to exercise. We also assessed the mitochondrial proteome of w1118 Drosophila that had been exercised for one week, alongside mitochondrial respiration measured using High-Resolution Respirometry, to determine changes in mitochondrial physiology in response to exercise. We found that age-targeted exercise interventions improve lifespan in male and female Drosophila, and grouped males exercised in late life had improved climbing scores, when compared with those exercised throughout their entire lifespan. The proteins of the electron transport chain were significantly upregulated in expression after one week of exercise, and complex II linked respiration was significantly increased in exercised -Drosophila. Taken together our study provides a basis to test specific proteins and complex II of the respiratory chain as important effectors of exercise induced healthy ageing.
Differences in the Performance of Permanent Employees and Contract Employees in the Furniture Industry
Authors: Firdaus Vera
Published: September 2021

Industri mebel merupakan sektor yang perkembangannya sangat kompetitif namuncenderung fluktuatif dalam permintaan. Penyerapan tenaga kerja yang tinggi pada industrimebel menuntut upaya efisiensi agar tenaga kerja tidak menjadi beban produksi, sehinggaperusahaan meenerapkan sistem kontrak pada karyawan. Tujuan penelitian ini untukmenganalisis apakah terdapat perbedaan yang signifikan antara kinerja pada karyawan tetapdengan karyawan kontrak. Penelitian dilakukan di 2 perusahaan di Jawa Timur. Tekniksampling menggunakan Cluster random sampling, sehingga diperoleh 50 karyawan tetap dan50 karyawan kontrak sebagai sampel penelitian. Teknik pengumpulan .data melaluikuisioner, studi pendahuluan, wawancara, observasi serta kajian publikasi ilmiah. Desainpenelitian ini Kuantitatif dengan pendekatan komparatif dua sampel. Analisis menggunakanIndependent Samples T Test dengan program SPSS versi 23. Hasil penelitian membuktikanbahwa terdapat perbedaan yang signifikan antara kinerja pada karyawan tetap dengankaryawan kontrak sebesar 1.820. Karyawan kontrak rata-rata memiliki kinerja lebih baik(mean 24,56) daripada karyawan tetap (mean 22,74) .
Enough with the madness: a systematic review and meta-analysis of hydroxychloroquine for COVID-19
Authors: Santos André , Gonçalves Érica , Oliveira Ananda , Lima Douglas , Noronha Kenya , Andrade Mônica
Published: September 2021

Objective: Because of preliminary results from in vitro studies, hydroxychloroquine (HCQ) and chloroquine (CQ) have been proposed as possible treatments for COVID-19, but the clinical evidence is discordant. This study aims to evaluate the safety and efficacy of CQ and HCQ for the treatment of COVID-19. Methods: A systematic review with meta-analysis was performed. An electronic search was conducted in four databases for randomized controlled trials that compared HCQ or CQ with standard-of-care. A complementary search was performed. A quantitative synthesis of clinical outcomes was performed using the inverse variance method adjusting for a random-effects model. Results: In total, 16 studies were included. The meta-analysis found no significant difference between intervention and control groups in terms of mortality at the most extended follow-up (RR = 1.09, CI95% = 0.99-1.19, p-value = 0.08), patients with negative PCR results (RR = 0.99, CI95% = 0.89-1.10, p-value = 0.86), or serious adverse events (RR = 2.21, CI95% = 0.89-5.47, p-value = 0.09). HCQ was associated with an increased risk of adverse events (RR = 2.28, CI95% = 1.36-2.83, p-value < 0.01). The quality of evidence varied from very low to high. Conclusion: There is no evidence that HCQ reduces the risk of death or improves cure rates in patients with COVID-19, but it might be associated with an increased risk of adverse events.
Early Mesozoic Rare-Metal Granites and Metasomatites of Mongolia: Mineral and Geochemical Features and Hosted Ore Mineralization (Baga Gazriin Chuluu Pluton)
Authors: Antipin V.S. , Kushch L.V. , Odgerel D. , Belozerova O.Yu.
Published: September 2021

—We present results of petrographic, mineralogical, and geochemical study of all types of rocks of a multiphase pluton and consider the chemical evolution of igneous and metasomatic rocks of the Baga Gazriin Chuluu pluton, based on new precise analytical data. At the early stage of their formation, the pluton granites were already enriched in many trace elements (Li, Rb, Cs, Be, Nb, Ta, Th, and U), F, and HREE relative to the upper continental crust. They show strong negative Ba, Sr, La, and Eu anomalies, which is typical of rare-metal Li–F granites. The geochemical evolution of the Baga Gazriin Chuluu multiphase pluton at the postmagmatic stage was marked by the most intense enrichment of greisens and microclinites with lithophile and ore elements (Sn, W, and Zn) and the formation of ore mineralization. In the permeable rift zone where the Baga Gazriin Chuluu pluton is located, the fluid–magma interaction took place under the impact of a mantle plume. High-temperature mantle fluids caused melting of the crustal substratum, which determined the geochemical specifics of Li–F granite intrusions. Genesis of granitic magma enriched in Li, F, Rb, Sn, and Ta is possible at the low degrees of melting of the lower crustal substratum. The Baga Gazriin Chuluu pluton formed in the upper horizons of the Earth’s crust, where magma undergoes strong differentiation and the saturation of fluids with volatiles can lead to the postmagmatic formation of metasomatites of varying alkalinity (zwitters (greisens), microclinites, and albitites) producing rare-metal mineralization. By the example of the early Mesozoic magmatism area of Mongolia, it is shown that the formation of granites and associated rare-metal minerals is due to the interaction of mantle fluids with the crustal material and the subsequent evolution of granitic magmas.
A New Strategy for Using Historical Imbalanced Yield Data to Conduct Genome-Wide Association Studies and Develop Genomic Prediction Models for Wheat Breeding
Authors: Chu Chenggen , Wang Shichen , Rudd Jackie C. , Ibrahim Amir M.H. , Xue Qingwu , Devkota Ravindra N. , Baker Jason A. , Baker Shannon , Simoneaux Bryan , Opena Geraldine , Dong Haixiao , Liu Xiaoxiao , Jessup Kirk E. , Chen Ming-Shun , Hui Kele , Metz Richard , Johnson Charles D. , Zhang Zhiwu S. , Liu Shuyu
Published: September 2021

Using imbalanced historical yield data to predict performance and select new lines is an arduous breeding task. Genome-wide association studies (GWAS) and high throughput genotyping based on sequencing techniques can increase prediction accuracy. An association mapping panel of 227 Texas elite (TXE) wheat breeding lines was used for GWAS and a training population to develop prediction models for grain yield selection. An imbalanced set of yield data collected from 102 environments (year-by-location) over ten years, through testing yield in 40–66 lines each year at 6–14 locations with 38–41 lines repeated in the test in any two consecutive years, was used. Based on correlations among data from different environments within two adjacent years and heritability estimated in each environment, yield data from 87 environments were selected and assigned to two correlation-based groups. The yield best linear unbiased estimation (BLUE) from each group, along with reaction to greenbug and Hessian fly in each line, were used for GWAS to reveal genomic regions associated with yield and insect resistance. A total of 74 genomic regions were associated with grain yield and two of them were commonly detected in both correlation-based groups. Greenbug resistance in TXE lines was mainly controlled by Gb3 on chromosome 7DL in addition to two novel regions on 3DL and 6DS, and Hessian fly resistance was conferred by the region on 1AS. Genomic prediction models developed in two correlation-based groups were validated using a set of 105 new advanced breeding lines and the model from correlation-based group G2 was more reliable for prediction. This research not only identified genomic regions associated with yield and insect resistance but also established the method of using historical imbalanced breeding data to develop a genomic prediction model for crop improvement.
Supratotal Resection of Glioblastoma Allows Better Survival Outcomes Than Gross Total Resection
Authors: Baik Seung Hyun , Kim So Yeon , Na Young Chul , Cho Jin Mo
Published: September 2021

Objective: Supra-total resection (SupTR) of glioblastoma allows superior long-term disease control and increases overall survival. On the other hand, aggressive conventional approaches, including gross total resections (GTR), are limited by the impairment risk of adjacent eloquent areas, which may cause severe postoperative functional morbidity. This study aimed to analyze institutional cases with respect to the potential survival benefits of additional resection, including lobectomy, as a paradigm for SupTR in patients of glioblastoma.Methods: Between 2014 and 2018, 15 patients with glioblastoma underwent GTR and additional lobectomy at our institution. The postoperative Karnofsky performance score (KPS), progression-free survival (PFS), and overall survival (OS) were analyzed for the patients.Results: Patients with SupTR showed significantly prolonged PFS and OS. The median PFS and OS values for the entire study group were 33.5 months (95% confidence intervals [CI]: 18.5–57.3 months) and 49.1 months (95% CI: 24.7–86.6 months), respectively. Multivariate analysis revealed that O6-DNA-methylguanine methyltransferase (MGMT) promoter methylation status was the only predictor for both superior PFS (p = 0.03, OR 5.7, 95% CI 1.0–49.8) and OS (p = 0.04, OR 6.5, 95% CI 1.1–40.2). There was no significant difference between the pre- and post-operative KPS scores. Conclusions: Our results strongly suggest that SupTR with lobectomy allows superior PFS and OS without negatively affecting the patient performance.
Novel Dihydroartemisinin Derivative Mito-DHA5 Induces Apoptosis Associated with Mitochondrial Pathway in Bladder Cancer Cells
Authors: Xiao Linfan , Xu Cangcang , Lin Peiyu , Mu Lingli , Yang Xiaoping
Published: September 2021

Background: Bladder cancer is the second most common genitourinary malignancy and the eleventh most common cancer worldwide. Dihydroartemisinin (DHA), a first-line antimalarial drug, has been found to have potent antitumor activity. In our previous study, a novel dihydroartemisinin derivative Mito-DHA5 synthesized in our laboratory has a stronger anti-tumor activity than DHA. In this study, we investigated the apoptotic effect of Mito-DHA5 on bladder cancer T24 cells and molecular mechanisms underlying. Methods: Antitumor activity in vitro was evaluated by MTT and cloning formation assays. Mitochondrial membrane potential (MMP) was detected by JC-1 probe and ROS levels were measured by specific kit. The expression of caspase-3, Bcl-2 and Bax in T24 cells was evaluated by Western blotting. Results: The results showed that Mito-DHA5 reduced cell viability with an IC50 value of 3.2 μM in a dose-dependent manner, induced T24 cell apoptosis at both early and late stages, increased the production of ROS and decreased MMP. Mito-DHA5 could down-regulate the expression of Bcl-2 and Caspase-3, and up-regulate the expression of Bax and cleaved Caspase-3. Conclusion: These data suggested that Mito-DHA5 had a potent inhibitory effect on T24 bladder cancer cell growth and induced these cells apoptosis associated with mitochondrial pathway.
Microvascular Changes In The Recurrent Cystoid Macular Edema Secondary to Posterior Noninfectious Uveitis on Optical Coherence Tomography Angiography
Authors: Albano Valeria , Guerriero Silvana , Furino Claudio , Sborgia Giancarlo , Sborgia Alessandra , Dammacco Rosanna , Boscia Francesco , Alessio Giovanni
Published: September 2021

BACKGROUND: Posterior uveitis represents the second most frequent type of uveitis (15-30% of all uveitis). Non-infectious posterior uveitis complicated with secondary cystoid macular edema (CME) negatively affected the visual prognosis.The objective of the current study is to determine possible microvascular changes that can cause a relapsing uveitis-CME through optical coherence tomography angiography (OCTA).METHODS: This is a case-control study, an evaluation of patients with secondary CME noninfectious posterior uveitis-related undergoing dexamethasone (DEX) implant. The visits following the DEX-implant were carried out after 1 month, 2-months, 4-months, 6-months, and for up 1-year. A total of 76 eyes of 38 consecutive patients with noninfectious posterior uveitis were enrolled (consecutive sample). Complicated noninfectious posterior uveitis with secondary CME was diagnosed in 56 eyes of uveitis patients (24.3%) reviewed. RESULTS: Our investigation showed a reduction in superficial vessel plexus (SVP) measurements already within 2-month (84%), reaching 96.4% for up 1-year, however displaying an irregular profile in 69.6% of cases, persisting for up 1-year; the relapsing uveitis-CME eyes with irregular superficial foveal avascular zone (FAZ) profile were in 51%, while the SVP measurements reestablished in 100% of cases. Conversely, the deep vascular plexus (DVP) parameters restored occurred in a lower number of eyes within the 2-month (39.3%), remaining abnormal in 46.4% of cases for up 1-year; despite DVP restored in 53.6% of cases for up 1 year, a capillary rarefaction ring around the FAZ appeared in 80.4% of cases; the relapsing uveitis-CME eyes with abnormal DVP parameters were in 41% of cases, of which 92.1% showed a rarefaction ring had abnormal DVP.CONCLUSIONS: The use of OCTA allows to evaluate the retinal microvascular features, which could be the cause of the recurrence of CME in uveitis patients, despite the DEX-implant treatment. We suggested that the possibility of the recurrence of the uveitis-CME depends on the persistence of modifications of the superficial and deep layers, which we therefore consider appropriate to investigate. With this purpose it would be useful to introduce OCTA into the current imaging armamentarium in follow-up of patients with noninfectious uveitis-CME.