bluuebunny/crossref_metadata_2025 huggingface dataset:
Convenient Synthesis of (Z)-7- and (E)-9-dodecene-1-yl Acetate, Components of Some Lepidoptera Insect Sex Pheromone
Authors: Andreica Adriana Maria , Gansca Lucia , Ciotlaus Irina , Oprean Ioan
Published: February 2020

Were developed new and practical synthesis of (Z)-7-dodecene-1-yl acetate and (E)-9-dodecene-1-yl acetate. The routes involve, as the key step, the use of the mercury derivative of the terminal-alkyne w-functionalised as intermediate. The synthesis of (Z)-7-dodecene-1-yl acetate was based on a C6+C2=C8 and C8+C4=C12 coupling scheme, starting from 1,6-hexane-diol. The first coupling reaction took place between 1-tert-butoxy-6-bromo-hexane and lithium acetylide-ethylendiamine complex obtaining 1-tert-butoxy-oct-7-yne, which is transformed in di[tert-butoxy-oct-7-yne]mercury. The mercury derivative was directly lithiated and then alkylated with 1-bromobutane obtaining 1-tert-butoxy-dodec-7-yne. After acetylation and reduction with lithium aluminium hydride of 7-dodecyne-1-yl acetate gave (Z)-7-dodecene-1-yl acetate with 96 % purity. The synthesis of (E)-9-dodecene-1-yl acetate was based on a C8+C2=C10 and C10+C2=C12 coupling scheme, starting from 1,8-octane-diol. The first coupling reaction took place between 1-tert-butoxy-8-bromo-octane and lithium acetylide-ethylendiamine complex obtaining 1-tert-butoxy-dec-9-yne, which is transformed in di[tert-butoxy-dec-9-yne]mercury. The mercury derivative was directly lithiated and then alkylated with 1-bromoethane obtaining 1-tert-butoxy-dodec-9-yne. After reduction with lithium aluminium hydride of 1-tert-butoxy-(E)-9-dodecene and acetylation was obtained (E)-9-dodecene-1-yl acetate with 97 % purity.
The Effects of Nanofillers on Composite Materials Mechanical Properties
Authors: Almasi Adrian , Porumb Anca , Podariu Angela Codruta , Todor Liana , Tofan Sergiu Alexandru , Popovici Ramona Amina
Published: February 2020

The goal study is benchmarking flexural strength FS of compressive strength CS, compression diametrical DTS (diametrically tensile strenght) and Vickers hardness for two nanocomposites experimental AD1 and AD3 achieved within the Research Institute in Chemistry Raluca Ripan Cluj Napoca and for the commercial product of the Kerr Premise company �. Electron microscopy aspects pre- and post-fracturing are also shown to highlight the structure of materials and spread
Multifocal Osteonecrosis Glucocorticoid Induced
Authors: Patrascu Alexandru , Savin Liliana , Lupescu Olivera , Mihailescu Dan , Mihai Dana Nicoleta , Neculaes Marius , Grigorescu Victor , Greierosu Carmen , Botez Paul
Published: February 2020

The present study describes a 29 years old patient diagnosed with aseptic osteonecrosis with multiple localization occurred after a corticoid treatment for chronic toxic hepatitis. The clinical and para-clinical examinations determined the diagnosis of Wilson disease and avascular necrosis with multiple localizations. The evolution of the disease was favourable following the surgical treatment consisting of bilateral total hip arthroplasty with cementless prosthesis, hemi-arthroplasty of the left shoulder with cementless prosthesis, orthotopic hepatic transplantation with an entire liver from donor in cerebral death and immunosuppressive, anticoagulant, antiretroviral and gastro-protective treatment. There is an increase of the number of patients undergoing a glucocorticoids treatment for several months, years or lifelong periods. This type of treatment increases the risk of osteonecrosis depending on the dosage and the duration of the treatment.
Preparation of New Oxadiazole Acyclic Nucleoside and Thioglycoside Analogs Containing Chromene Moiety with Antimicrobial Evaluation
Authors: Alotaibi Mshari A. , Essawy Farag A. El , Boshta Nader M.
Published: February 2020

New sugar hydrazones linked to chroman ring system and their derived oxadiazole acyclic nucleoside analogs were synthesized from the substituted ethyl ester oxime derivative. The 2-sustituted 1,3,4-oxadiazole-5-thione prepared from acid hydrazide was glycosylated to afford the corresponding thioglycosides, not the N-linked glycosides. The novel compounds were evaluated for their antimicrobial activity and showed different degrees of activities.
The Effect on Health of Some Cardiovascular Risk Factors
Authors: Savoiu Balint Germaine , Andoni Mihaiela , Popovici Ramona Amina , Rusu Laura Cristina , Citu Ioana , Rumel Ramona Camelia , Ciobanu Virgil
Published: February 2020

Arterial endothelium produces a large ramge of active factors which are indispensable for modulation of vasomotor tone and maintenance of vascular wall integrity. From these factors, nitric oxide (NO), wich is released by the endothelial cells as a response to acetylcholine or adenosine action on specific receptors, plays an important role.NO is the result of oxidation process of L-arginine into L-citrulline, under the action of endothelial nitric oxide synthase (NOSe), wich is activated by intracelluar Ca2+ - calmodulin complex . Our study, performed in isolated organ bath, analyzed vascular reactivity of 12 guinea pigs� thoracic aorta rings. After phenylephrine -PHE 10-5 mol/L precontraction, the dose-effect curves for acetylcoline � ACH, adenosine 5� phosphate - 5�ADP and sodium nitroprusside � SNP were determined, before and after incubation of preparation, for 1 hour, with 5% hydrosoluble cigarettes smoke extract (CSE). Statistic analysis, performed with the use of t pair test and ANOVA parametric test, showed that incubation of vascular preparation with 5% CSE has increased the contractile response to PHE 10-5 mol/L (p[0.05), has reduced the endothelium-dependent relaxing response to ATP 10-5 mol/L (p[0.001) and 5�ADP 10-5 molo/L (p[0.001), but has not significantly modified the endothelium-independent relaxing response to SNP 10-5 mol/L (p=0.05). As a conclusion, vascular rings incubation with 5% CSE induced a decrease of endothelium NO synthesis under the action of AXH and 5�ADP, but did not change the smooth muscle fiber respomse in the presence of NO released by SNP.
Restoration the Dent- stomato-facial Aesthetic Balance, a Target of Dental Therapy, Regardless the Patient`s Age
Authors: Cerghizan Diana , Branasco Tatiana , Brujbu Isabella Cristina , Toma Vasilica , Iordache Cristina
Published: February 2020

For centuries, literature and art have indicated that the smile has its own beauty and that it has an essential role in facial aesthetics. The principles associated with the discovered systems make it easier for the dentist to achieve superior aesthetics. The aesthetic and prosthetic importance of the teeth is substantial, which makes all the methods of treatment - essential. The smile is one of the expressions of the human face that influences our image and relationships with others. The self-confidence, the satisfaction of a pleasant appearance and the charisma of a jovial person conquer at first sight and categorically represent an asset. Dental cosmetics became more complex, much more an art than science; through it, each of us have the ability to change the appearance of the teeth. We can expect different recognition and appreciation abilities in terms of optimal dento-facial aesthetics by partial or total edentulous patients. The characteristic of dental-facial aesthetics are somewhat related to civilization, origin and geographical area. The restoration of the dental-somato-facial aesthetic balance represents a desideratum of dental therapy regardless of age. A good knowledge of the principles of evaluation of the dental and somato-facial aesthetic equilibrium as well as of the principles and individualized restoration methods can provide the dentist with success in the therapeutic approach. The study was conducted on a group of 71 patients, between 2015-2016, belonging to different social backgrounds and age categories. Treatments needed for the clinical situations in the investigated study lot were grouped into: two or more obturations (with the highest weight in the investigated clinical situations), followed step by step by: fixed prosthesis-microprosthesis or aggregation element, fixed prosthesis deck body; endodontic treatment; extractions. The need for treatment at the level of the frontal group is represented primarily by obturation, followed by conjunctions (unidirectional prostheses or aggregation elements). Extractions also occupy an important place.
Semiology of the Pain Syndrome - Identifying the Ideal Methods of Locoregional Anesthesia Based on Their Rationale and Features
Authors: Scutariu Mihaela Monica , Danila Vlad , Ciupilan Corina , Ciurcanu Oana Elena
Published: February 2020

Anesthesia and the degree of control over the perception of pain depends on the personality of the individual, the socio-economic conditions, potential previous painful experiences and, last but not least, on fatigue and fear of the dentist. The perception of pain in patients is closely connected to their mental state. Pain is defined as a sensation of discomfort, with wide variations, both in quality and intensity, for different people in seemingly identical conditions; an unpleasant sensitive and emotional phenomena connected to the threat of a wound or caused in the tissues or described in the terms of this disease. The essential element of any type of anesthesia is analgesia, an effect which in some cases cannot be achived, due to the patient�s particularities or the physician�s lack of experience in anesthesia. Locoregional anesthesia (LRA) represents the blocking of the nociceptive sensitive and sympathetic autonomic afferents as well as that of motor efferents at the level of peripheral nerves� axons, by means of local anesthetic. To achieve the set purpose, we carried out a study on a representative human sample comprised of 10.123 patients treated in the Oral and Maxillofacial Surgery Clinic (Ambulatory) from the County Clinic Emergency Hospital St. Spiridon Iasi, between 01.01.2015-31.12.2016. The reason for the exclusion of certain categories of patients in the reseach was: the patients with a special conditions background require individual pre-anesthesia schemes, personalised for the nature of the pre-existing general condition, which must be further approved by the attending specialist physician : cardiologist, internist, diabetologist; children under 18 years old, with a high degree of anxiety; a high precentage of elderly patients, over 60 years old, possess a combination of general issues, thus requiring a special approach. The thoroughness lying at the core of the anesthetic practice, most especially the safegurading of a technical accuracy in the performance of anesthesia [12,], instead of improvisations, the lack of anatomical and stomatological training in general and the resulting inefficiency as such, is the underlying in-depth structuring element of this paper.
Biochemical Interactions Between Angiotensin II and Apelin in Isolated Vascular Smooth Muscle Cells
Authors: Tatarciuc Diana , Gentimir Carmen , Zaharia Catalina Anda , Costin Andreea , Chelaru Liliana , Cazan Ionut , Stoleriu Gabriela , Costuleanu Marcel
Published: February 2020

Angiotensin II, angiotensin receptors, apelins and recently de-orphanized APJ receptors are important control factors of cardiovascular system. The present studies aimed the effects of apelin-13 and [Pyr1]-apelin-13 on apoptosis of cultured rat vascular smooth muscle cells, induced by enhanced concentrations of angiotensin II, in the presence of losartan, a specific inhibitor of AT1 angiotensin receptors type. The obtained data demonstrated that apelin-13 was less efficient in preventing the apoptosis of aortic smooth muscle cells in culture, induced by angiotensin II (in the presence of losartan), as compared to [Pyr1]-apelin-13. It could be concluded that the apoptotic effects induced by angiotensin II in rat aortic could be related to the involvement of AT2 angiotensin receptor type, other types of receptors or pathways unrelated to angiotensin receptors. Furthermore, the apoptotic effects induced by angiotensin II are counteracted by apelins in a structure-related manner.
Oral Manifestations of Osteoarticular Diseases
Authors: Macovei Luana Andreea , Cristescu V. , Debita Mihaela , Dinu C. A.
Published: February 2020

Human body acts as a whole and this leads to an increased occurrence of oral manifestations during the onset and development of systemic diseases. Therefore, oral pathological manifestations play an important role in the diagnosis, prognosis and treatment of diseases with osteoarticular involvement. General pathology has a strong impact on oral health which in turn is influenced by systemic factors. Oral manifestations can be used for making an early diagnosis of a serious condition that can be cured with appropriate therapy. Oral lesions can be explained by pathological processes and correlated with systemic diseases. When oral symptoms and signs are present, the disease is already in an advanced stage, due to the fact that the oral cavity is usually affected by a generalized disease. The mouth is part of the digestive system, but it has various symptoms caused by diseases located in other regions. 98 patients with oral manifestations of diseases with osteoarticular involvement were followed up in a private dental clinic from Iasi over a period of 3 years between June 2013 and July 2016. 47 patients were male (47.95%) and 51 were female (52.05%), aged between 18 and 65 years old, with a peak incidence between the ages of 45 and 60. The complex structure of the oral cavity was thoroughly explored (lips, lip mucosa, the corners of the mouth, gingival labial sulcus, oral vestibule, the internal face of the cheeks, the outer surface of gums, the floor and the ceiling of the oral cavity or the hard and the soft palate). The health status of the body is reflected by the health of the oral mucosa, which can be seen as a marker of various systemic diseases.
HPV Cervical Cancer Screening. An Analysis Over HPV Markers Between Worldwide Statistics and Romanian Reality
Authors: Popa Zoran , Chiriac Veronica Daniela , Cobec Ionut Marcel , Lungeanu Diana , Craina Marius , Bernad Elena , Ionita Ioana , Moleriu Radu Dumitru , Iacob Daniela , Petre Izabella
Published: February 2020

The aim of the paper is to present our results on HPV types among adult women diagnosed with invasive cervical cancer and HPV types. All the patients have been diagnosed with CIN 2+. The cross-sectional survey was conducted at the Department of Obstetrics and Gynecology from the County Emergency Hospital Timisoara, Romania, during January 1, 2008, up to December 31, 2010. HPV determination was made using DNA amplification by the Polymerase Chain Reaction (PCR) technique and nucleic acid hybridization detection of 37 anogenital HPV genotypes.
Good Practices in Evaluating the Uncertainty of Measurements for the Conductivity of the Electrolyte Solutions
Authors: Lazar George , Campureanu Claudiu , Cirneanu Ioan , Vaireanu Danut Ionel
Published: February 2020

This paper intends to present the theoretical background as well as practical illustrations for good laboratory practices in conductivity measurements, ways to increase the accuracy of conductivity measurements as well as how one may evaluate the uncertainty of conductivity measurements for the electrolyte solutions. Practical measurements for prepared standards of 1 M KCl and 0.1 M KCl solutions are carried out and the values of repeatability, composed uncertainty and expanded uncertainty are presented.
Ultrastructural Changes of Candida albicans Species Induced by the Presence of Sodium Diclofenac
Authors: Rusu Elena , Sarbu Ionela , Mitache Magdalena , Moldovan Horatiu , Biris Carmen Ioana , Vassu Tatiana , Pelinescu Diana
Published: February 2020

The high frequency of occurrence of candidiasis as well as high mortality of patients with immunosuppression cause a tendency toward better understanding of Candida albicans species virulence factors and developing sensitive and specific diagnostic methods, and appropriate strategies of candidiasis treatment. In recent decades the incidence of fungal infections has alarming increases because of advanced medical treatments. In this study was analyzed possible ultrastructural changes of the species C. albicans cells following treatment with sodium diclofenac at various concentrations. Following treatment of C. albicans cells with sodium diclofenac 1 mM and 2 mM changes in the plasmalemma can be noticed, changes in the density of cell wall, disruption and necrotic appearance of the cytoplasm.
Postmortem Diagnosis of Hypertonic Dehydration by Chemical Analysis of Vitreous Humor
Authors: Damian Simona Irina , Nedelea Paul , David Sofia , Knieling Anton , Moldoveanu Sorin , Sandu Ion , Iov Catalin Jan
Published: February 2020

The aim of forensic autopsy is to accurately reconstitute, as much as possible, the circumstances of death (the cause of death and the mechanism of death, the post-mortem interval, the related pathology and its role, the survival interval). Post-mortem biochemical analyses can help to various extents in establishing these issues. In order to elucidate the issue of post-mortem biochemical investigations, we conducted an analysis of forensic casuistry within a delimited territory, for a period of 3 years in order to identify the elements necessary for the diagnosis of hypertonic dehydration. By grouping the cases depending on the immediate cause of death, the diagnosis criteria for hypertonic dehydration showed the possibility of performing the differential diagnosis by biochemical analyses performed in vitreous humor (sodium, chlorine, urea, creatinine), the criteria being not met in any of the other groups.
Study of the Occurance of Labio-Palatine Cleft Embryogenic Disorders of the Stomatognated System by Using Lots of Wistar Rats Females
Authors: Ciupilan Corina , Hinganu Marius Valeriu , Hinganu Delia , Ciurcanu Oana Elena , Scutariu Mihaela Monica
Published: February 2020

Labio-maxilo-palatine clefts are embryogenesis disorders of the stomatognathic system that occur due to the action of genetic or non-genetic factors in weeks 5-6 of intrauterine life. The clefts are part of the group of congenital malformations of the face. They appear from birth as a slit in the upper lip, hard palate and/or soft palate.Labio-maxilo-palatine cleafts are a current medical problem, especially regarding surgical recovery; they are congenital malformations of the face characterized by the absence of substance in the upper lip and/or in the palatine vault caused by the lack of fusion of labial and / or palatine buds during embryonic development.Simple labial cleft concerns only the lip, unlike the complete labial cleft which affects also the alveolar maxillary arch. In the case of this malformation, more serious than labial cleft, the cleft also affects the bone structures (the alveolar maxillary arche, the buccal palate) so that the oral cavity communicates with the nasal cavity and prevents sucking in infants. An early surgical recovery restores the integrity of anatomical structures, reestablishes disturbed functions, creates favorable conditions for speech education and social adaptation of the child according to age.The procedure is applied prior to the primary suture of the lip and of the anterior palate in order to minimize the dislocation of the segments of the maxillary arch. The correction of the malformation of the jaw arch in the case of bilateral clefts is much more difficult, but it has a greater importance due to the difficulty of reconstruction of the muscular plan and severe deformations, what will persist if the segments can not be aligned.In the bilateral clefts, the lateral segments are displaced medially, and the medial segment is protruding. The purpose of preoperative orthodontic treatment is to reposition the lateral segments so that the medial segment can be coaxed between them together as a vault key of the maxillary arch. In order to study the occurrence of labio-palatine cleft, we used eight groups of Wistar females rat, weighing between 200 and 250 grams. Each sample consists of 10 females rats. Most of the labial and palatine clefts are the result of multiple, genetic and non-genetic factors, each producing a minor developmental defect, called multifactorial heritage;It can be represented by a model in which responsibility for a disease is a variable caused by a combination of genetic and environmental factors. The therapeutic outcome depends on the complexity of the malformation, on the moment of surgery and on the selection of the most modern techniques and equipment suitable for the patient.
In vivo Experiments of Natural Products Protection of Antagonistic Effects of Lead on Iron
Authors: Nicula Marioara , Pacala Nicolae , Stef Lavinia , Pet Ioan , Dronca Dorel , Gherbon Adriana , Ahmadi Mirela
Published: February 2020

Living organisms take nutrients from the environment, and together with them, substances with toxic potential � such as heavy metals. Lead is one common metal pollutant especially in aquatic environment, from where the fish can be intoxicated very easily. Bioavailability, distribution, toxic action, synergistic and antagonistic effects are characteristics which can alter the fish health. Our experimental study followed the effects of lead overload in water on iron distribution, in different tissues sample Carassius gibelio Bloch fish. We performed the experiment in four different fish groups: control C; lead � Pb (administration of lead in water 0.075mg/mL of water, as Pb(NO3)2 x � H2O); lead (the same dose) and 2% of freeze-dry garlic incorporated into fishes� food � Pb+garlic; lead (the same dose) and 2% chlorella incorporated into fishes� food � Pb+chlorella, for 21 consecutive days. The iron concentration was analysed with AAS (Atomic Absorption Spectroscopy) from gills, muscle, skin (and scales), intestine, liver, heart, brain, ovary, testicles, and kidney. The obtained data presented a significantly decrease of iron content in all tested tissue samples that demonstrated, alteration of iron homeostasis, explained by a strong antagonistic effect of lead on iron. Our experiment showed that biologic active principles from garlic and chlorella act like natural protectors, and potentiate the iron deficiency even in the case of lead overload in aquatic environment, for fish.
Neutralization of Acid Mine Drainage with Wood Ash
Authors: Barbu Constantin Horia , Pavel Petronela Bianca , Moise Cristina Maria , Sand Camelia , Pop Mihai Radu
Published: February 2020

The paper presents the research activities oriented to solving two environmental issues of concern: acid mine drainage that poses a great risk to soils and water, and wood ash disposal, which can be done only under strict conditions, with high costs. After trials with synthetic acid waters, the behavior of four types of ash has been investigated. The ashes used were originated from two boilers belonging to a fiberboard manufacturer, individually and mixed according to their production process, using acid mine drainage from a copper mine. Acid mine drainage has been characterized in what concern pH, fix and mineral residues, as well as Fe, Cu, Zn and Mn content. For all ashes and their mixtures, the pH (water suspension 1:5), humidity, as well as their neutralization capacity have been determined. The obtained results have been very good, proving that wood ash has better neutralization capacity than calcium carbonate, thus enabling to pursue and extend the present research work.
In vitro Comparative Study on the Effect of Carbonated Beverages on Dental Enamel
Authors: Biclesanu Cornelia Florentina , Manea Stefan , Alexandrescu Oana , Nazem Dawod , Pangica Anna Maria , Banita Monica , Florescu Anamaria
Published: February 2020

In recent decades, significant worldwide increase in the consumption of acidic beverages, such as soft drinks and fresh fruit extended to all categories of consumers but especially to young people. The purpose of this study is to demonstrate the effect of some of the most consumed beverages on dental enamel in order to draw an alarm signal. The study was performed in vitro on 18 extracted teeth. Half of the coronary enamel was covered with a nail polish, then the teeth were submerged in hermetic containers with the most commonly used beverages: Coca Cola, sugar-free Coca Cola, orange juice, red wine, green tea, Red Bull for one hour, one day, 3 days and 7 days. Evaluation of the samples at one hour, one day and 3 days was performed by examination at the optical microscope. After 7 days, the insulating nail polish was removed and the microstructure of the enamel exposed and not exposed to acidic action, was examined under the scanning electronic microscope (SEM). Results showed that because of the high acidity of the beverages used in the study, the surface of the enamel showed prisms changes, structural loss of the enamel, which can lead to cracks and structural disintegration with the reduction of the physical and mechanical properties of the enamel. The results obtained in this in vitro study should be reinterpreted and associated with the in vivo situation where biological factors such as bacterial plaque and saliva buffering capacity are likely to reduce the potential for erosion of beverages. Consequently, enamel erosion may be lower compared to the measurements found in this study.
The Role of Chemical Substances in Classic and Modern Sialography Technique and applications
Authors: Haba Danisia , Budacu Cristian , Constantin Mihai , Costan Victor Vlad , Nemtoi Alexandru
Published: February 2020

The purpose of this study was to assess the role of a chemical contrast medium used in plain x ray and CBCT (cone beam computed tomography) sialography imaging in the detection of different changes associated with lesions of salivary glands. 20 subjects were recruited into this prospective clinical study over a 1 year time period. Sialography was performed by an oral and maxillofacial surgeon. A lateral skull plain image was then made and a three-dimensional scanning using a CBCT machine. The imaging volume was centred on the gland of interest. The lateral skull plain images represented the two-dimensional part of the study, and these were used for comparison with the three-dimensional investigation, the CBCT images.
Non-operative Risk Factors and the Implications of Sandostatin for Postoperative Pancreatic Fistula in Malignant Pancreatic Surgery
Authors: Andriesi Delia Rusu , Trofin Ana Maria , Cianga Spiridon Irene Alexandra , Lupascu Ursulescu Corina , Lupascu Cristian
Published: February 2020

Pancreatic fistula is the most frecquent and severe postoperative complication after pancreatic surgery, with impressive implications for the quality of life and vital prognosis of the patient and for these reasons it is essential to identify risk factors. In the current study, who included 109 patient admitted to a single university center and who underwent pancreatic resection for malignant pathology, we assessed the following factors as risk factors: age, sex, preoperative hemoglobin value, preoperative total protein value, obesity and postoperative administration of sandostatin. Of the analyzed factors, it appears that only obesity and long-term administration of sandostatin influences the occurrence of pancreatic fistula.
Surfactants Efficiency in Oil Reserves Exploatation
Authors: Ghetiu Iuliana , Stan Ioana Gabriela , Panaitescu Casen , Jinescu Cosmin , Mares Alina Monica
Published: February 2020

The use of surfactants in the process of water separation from crude oil emulsions formed at extraction is an effective solution in the treatment of crude oil. But perfecting this technology to a higher degree of efficiency, in order to destabilize the emulsion formed, requires the determination of the parameters involved in the design and the correlation of the obtained results. This research also aims at finding optimal solutions that increase the degree of water separation from emulsions using surface-effective solutions to destabilize the emulsion layer. This research was basedon data from two wells that extract oil from Barc�u reservoir. To achieve this objective, the composition of crude oil was analyzed, the emulsion characteristics were established and the elected demulsifiers were tested. The study highlights the efficiency of destabilization up to 97.9 mass %.
The Impact of Copper in Children with Attention Deficit Hyperactivity Disorder
Authors: Tudosie Mihail Silviu , Truta Elena , Davitoiu Ana Maria , Stanciulescu Luminita , Jinescu George , Mitu Ana Mihaela , Forje Margarita , Horhota Luminita , Bojescu Alexandra Andrada , Mares Alina Monica , Ionica Mihai
Published: February 2020

During one year (september 2013 � september 2014), 50 children from the residential institution for children SOS Satele Copiilor Bucharest, where included in our research. The children were distributed in two groups: Group A which consisted of 25 children (12 girls, 13 boys) who were not diagnosed with attention deficit hyperactivity disorder (ADHD) and Group B which consisted of 25 children (14 boys, 11 girls) who were diagnosed with ADHD. Initially, the two groups were subjected at a psycho-diagnostic battery of tests, one of them being the Evaluating the Health State of children with ADHD questionnaire elaborated by us, particularly for this research, with the purpose of highlighting the direct link between the children health state and their ADHD symptoms. This study sought to determine the concentration of copper in urine samples from a group of children with ADHD and a group of normal children, to highlight the role of copper in the development of ADHD symptoms. Levels of copper concentration in urine samples from the two groups were processed by Student�s t-Test. Statistical analysis showed that the arithmetic averages of copper concentration in urine samples, of the two groups do not differ significantly, so copper may be causing ADHD symptoms occur. The copper content in urine samples has been determined using atomic absorption spectrometry with graphite furnace.
Synthesis, Characterization and Thermal Degradation of Some New 3,5-dimethyl Pyrazole Derivatives
Authors: Mocanu Anca Mihaela , Luca Constantin , Luca Alina Costina
Published: February 2020

The purpose of this research is to synthetize, characterize and thermal degradation of new heterolytic derivates with potential biological properties. The derivates synthesis was done by obtaining new molecules with pyralozone structure which combine two pharmacophore entities: the amidosulfonyl-R1,R2 phenoxyacetil with the 3,5-dimethyl pyrazole which can have potential biological properties. The synthesis stages of the new products are presented as well as the elemental analysis data and IR, 1H-NMR spectral measurements made for elucidating the chemical structures and thermostability study which makes evident the temperature range proper for their use and storage. The obtained results were indicative of a good correlation of the structure with the thermal stability as estimated by means of the initial degradation temperatures as well as with the degradation mechanism by means of the TG-FTIR analysis.
Anti-Tumor Necrosis Factor Alpha Therapy and Periodontal Inflammation in Rheumatoid Arthritis. A clinical and biochemical approach
Authors: Ancuta Codrina , Ancuta Eugen , Chirieac Rodica , Antohe Magda , Iordache Cristina
Published: February 2020

Although the relationship between periodontal disease and rheumatoid arthritis (RA) is widely documented, centered by common pathobiologic pathways, the effect of various tumor necrosis factor alpha (TNF) antagonists in modulating not only inflammatory and immune articular damage, but also periodontal microenvironment remain debatable. We aimed to evaluate the periodontal status with and without TNF inhibitors in RA patients and to identify potential relation among these entities. We performed a prospective longitudinal 6-months analysis on 96 RA initiating their first biological therapy. Standard assessments included a dual rheumatologic (RA activity, disability, serological, inflammatory prolife) and dental evaluation such as plaque index (PI), gingival index (GI), bleeding on probing (BOP), pocket depth (PD), clinical attachment level (CAL). More than half of RA presented at baseline with chronic periodontitis, as suggested by high prevalence of sites with dental plaque, abnormal BOP, PD and CAL. Advanced inflammatory (CRP, ESR) and immune (anti-cyclic citrullinated peptide antibodies, ACPA) markers were described in RA subsets presenting with aggressive periodontal diseases, while significant correlations between dental pathology, RA activity and ACPA levels were also reported (p[0.05). Furthermore, we revealed significant improvement in both RA-related characteristics and periodontal status after 6 months of anti-TNF therapy (p[0.05). RA, particularly active severe, ACPA positive disease, is essentially accompanied by comorbid periodontal disease. TNF blockade is efficient in patients with active RA and potentially able to modulate the inflammatory process in the periodontal tissue.
Malondialdehyde and Lipofuscin Biomarkers of Oxidative Stress in Rana temporaria temporaria During Metamorphosis
Authors: Sirbu Vasile , Pallag Annamaria , Hoeniges Ana , Cojocaru Sabina Ioana
Published: February 2020

Anuran amphibians metamorphosis represents a model for the study of different processes, including tissue remodeling. One of the body�s systems whose morphological and structural properties are deeply transformed during metamorphosis is the digestive tract. The only structure in the digestive tract which is destroyed and then replaced with a new tissue (histolysis and histogenesis) under the action of oxidative stress and hormones, is the intestinal epithelium. Oxidative stress may be related to the production of malondialdehyde and the accumulation of lipofuscin. The two substances can be considered biomarkers of this process.
Ethnoveterinary Uses of Medicinal Plants in Mediterranean District, Turkey
Authors: Yipel Mustafa , Yipel Fulya Altinok , Tekeli Ibrahim Ozan , Guzel Yelda
Published: February 2020

Ethnoveterinary Medicine (EVM) research is defined as the reevaluation of the animal disease prevention and treatment folklore dating back to 14,000 years using modern and scientific methods. The knowledge acquired in centuries by trial and error has been used in medicine and has reached today by being transferred from generation to generation. As the science of chemistry has developed after the 18th century, synthetic or semi-synthetic materials have replaced the plants as raw materials for drugs. However, the emerging problems caused by the side effects of modern drugs in the recent years have popularized the use of natural drugs again. This study is conducted in the Mediterranean Region which is ranked at the top of medical aromatic plant diversity list in Turkey. 60 participants living in the region, chosen by random sampling have been interviewed face-to-face and we have tried to measure their knowledge about the plants they use for EVM. The obtained information has enabled us to make 168 citations to 67 different plants used in animal diseases. L. nobilis L., (%7.14), Mentha spp. and Urtica urens L. (%4.17) were the most prominent among these plants and it was reported that the medicinal plants were mostly used for gastrointestinal disorders (%26). Although EVM parctices reached today and are still being widely applied, the recorded information about this subject in Turkey and many other countries is inadequate. This study presents information about the plants used in Turkey�s Mediterranean region for EVM and how they are used to treat which diseases.
Microwave Assisted Synthesis of 5-hydroxymethylfurfural Using Mild Reaction Conditions
Authors: Gavrila Adina Ionuta , Asofiei Ioana , Trifan Adrian , Chipurici Petre , Rusen Edina
Published: February 2020

5-Hydroxymethylfurfural (5-HMF) is an important platform molecules, being a green precursor for a variety of high performance fuels and valuable chemicals. The production of 5-HMF from fructose under microwave-assisted heating conditions by varying different parameters (catalyst, temperature, stirring rate and reaction time) was studied. Microwave assisted synthesis leads to a shorter reaction time (40 min versus 150 min for conventional method) and the energy consumption is lower compared with the conventional method. Homogeneous and heterogeneous catalysts were tested. Although homogeneous catalysis produced the highest conversion of fructose to 5-HMF, ion exchange resins are preferable for industrial development and the best results were obtained for Dowex resin.
Assessment of Drinking Water Quality of Targu Jiu City by Analyzing Physical and Chemical Quality Parameters
Authors: Cirtina Daniela , Capatina Camelia
Published: February 2020

Monitoring and control of water quality for human consumption aims to verify if the water available to consumers meets the requirements of relevant legislation and in particular the values of parameters established. The paper presents a study on the assessment of the quality of drinking water distributed in the city of Targu-Jiu by analyzing the following physico-chemical quality parameters: pH, conductivity, turbidity, ammonia, nitrites, nitrates, chlorides, residual chlorine, hardness and aluminum ions content. From the results, it has been found that during 2013-2015, there were exceedings of the maximum permitted levels for residual chlorine and ammonium ion in drinking water samples.
Microstructure and Properties of Copper and 5754 Aluminum Alloy Joints by Friction Stir Welding
Authors: Iordache Daniela Monica , Ducu Marian Catalin , Nitu Eduard Laurentiu , Iacomi Doina , Plaiasu Adriana Gabriela , Pasare Maria Minodora
Published: February 2020

Welding dissimilar materials aluminum and copper by FSW are of great interest because Al and Cu are two most common engineering materials widely used in many industries. The paper analyzes the microstructure and mechanical properties obtained by butt of dissimilar material Cu - Al alloys (EN-AW-5754) by FSW. The joining by FSW process of the two samples (5 mm thickness) was performed with the pin of the tool tangential to copper plate. The values of the process parameters were the same in both cases: the rotation speed of the pin 1200 [rpm] and feed rate 60 [mm / min]. The microstructure was examined in 6 zones covering the whole thickness of the plates, Vickers microhardness was measured along a perpendicular line to the nugget and residual stresses.
Theoretical Investigations of the Structural, Magnetic and Electronic Properties of F2-xMnGe:Cux Alloy
Authors: Gruszka Konrad , Nabialek Marcin , Szota Michal
Published: February 2020

The paper presents results of theoretical investigations on the structural, magnetic and electronic properties of Fe2-xMnGe:Cux Heusler alloy focusing on the role of iron-copper substitution effects on selected parameters. The calculations were performed on the basis of the density functional theory approach using the plane-wave basis set. The substitution of [Ar]4s1 3d10 copper in place of [Ar]4s2 3d6 iron site was investigated.Among the many interesting properties exhibited by those alloys such as shape memory effect, half-metallicity, magnetoresistance etc. they also demonstrate significant sensitivity to various doping affecting their magnetic characteristics such as magnetic ordering or total magnetic moment, often demonstrating the Slater-Pauling behavior. The Cu substitution caused break of half-metallic character at the same time resulted in increase of magnetization.
Synthesis and Biological Evaluation of a New Schiff Base and its Cu(II) Complex
Authors: Tantaru Gladiola , Poiata Antonia , Bibire Nela , Panainte Alina Diana , Apostu Mihai , Vieriu Madalina
Published: February 2020

A new Schiff base ligand, N-hydroxy-N�-salicylidene-urea was synthesized through the condensation of salicylaldehyde with hydroxyurea. The copper(II) complex of the Schiff base has been also obtained. Their structure has been proven using spectral methods such as UV-Vis, FT-IR, 1H-NMR and elemental analysis. The antimicrobial activity of the copper(II) complex was evaluated through comparison to the activity of the Schiff base on various bacterial strains. All tested compounds were very active against both gram-positive and gram-negative bacteria.
Budd-Chiari Syndrome:Rare Cause, But Important of Portal Hypertension
Authors: Balan Gabriela , Pelin Ana Maria , Macovei Luana Andreea , Plesea Condratovici Alina , Plesea Condratovici Catalin , Busil Camelia
Published: February 2020

Budd-Chiari syndrome (BCS) (artery-occlusive hepatic disease) is a rare disease characterized by the obstruction of the blood flow at the level of the suprahepatic veins till their flow in the inferior vena cava (IVC) or at the level of IVC on the segment between the suprahepatic veins and the right atrium. The most frequent symptoms are abdominal pains, hepatomegaly and ascites. The imagistic investigations have an essential role in the early establishment of the diagnostic, evaluating the extension of disease and the management of BCS. Treatment depends on the presence or absence of symptoms and how acute the disease is.We present the case of a 43-years old woman, who had had for two month dyspeptic symptoms, increase of volume of the abdomen and oedema in the lower limbs. The biological investigations indicated hepatic dysfunction and thrombocytosis. The abdominal ultrasound showed modifications of chronic hepatopathy with signs of portal hypertension. The abdominal computer-tomography emphasized hepatomegaly with multiple nodules of regeneration, signs of portal hypertension (splenomegaly, moderate ascites), caudate lobe hypertrophy and thrombosis IVC. The patient was diagnosed with BCS and essential thrombocythemia. She started the medical treatment and was listed for liver transplantation. Budd-Chiari syndrome has to be taken into account every time we investigate the etiology of an acute or chronic hepatopathies, because the early diagnose can improve the patient�s prognostic.
Growth Differential Factor 15 (GDF%15), Possible Biomarker in Heart Failure
Authors: Dinca Valeriu Gabi , Manole Gheorghe , Cochior Daniel , Dinca Alexandra Ligia
Published: February 2020

The present study aims at determining on the one hand the growth differentiation factor 15 significance as possible risk biomarker for this condition and, on the other hand, the degree of correlation between its serum concentration and the class of inotropism deficit.The value of the current research stems from the very selected theme, the activity of GDF-15, member of the superfamily of cytokines TGF-b recognized as having implication in atherosclerosis, but almost unexplored as role in the myocardiumremodeling processes, more precisely in fibrosis.
The Adsorbtion of Lead, Copper, Chrome and Nickel Ions from Waste Waters in Agricultural Argilaceous Soils
Authors: Pincovschi Irina , Neacsu Nicoleta , Modrogan Cristina
Published: February 2020

The aim of this work is the study of te adsorption process of some heavy metals like lead, copper, chrome and nickel in agricultural argilaceous soil in order to put in evidence the influence of adsorption conditions on adsoption process. The adsorption isotherms, Langmuir and Freundlich, have been used to describe the adsorption equilibrium. The experimental data put in evidence that the adsoption capacity of heavy metals increases in order Ni2+ (about 110 micromol/g), Pb2+ (about 150 micromol/g), Cr3+ (about 300 micromol/g) and Cu2+(about 350 micromol/g). In all cases, the Langmuir isotherm reflects more exactly the adsorption process, being recomended for thermodynamic parameters determination.
The Result of Loads Superposition Upon the Matter and Particularly Upon the Environment
Authors: Jinescu Valeriu V. , Manea Simona Eugenia , Jinescu Cosmin
Published: February 2020

It is analyzed: � the actions whose effects are different stresses that can load a body or the environment; � the superposition problem of two or several loads. On the basis of critical energy principle, a relationship is established, consisting of dimensionless values, for the evaluation the stress state with respect to a value defined as admissible state. The result can be applied to loads superposition in some cases, such as: � solid bodies; � environmental pollution with a single sort of pollutant; � environmental multiple pollution: chemical, radiations and magnetic.
Fast HPLC Method for the Determination of Piroxicam and its Application to Stability Study
Authors: Panainte Alina Diana , Vieriu Madalina , Tantaru Gladiola , Apostu Mihai , Bibire Nela
Published: February 2020

A fast and robust RP-HPLC isocratic method was developed for determination of piroxicam in bulk materials and pharmaceutical formulations. Optimum separation of piroxicam and stress induced degradation a product was achieved using a SB-C18 Eclipse column (150x4.6; 5�m). The mobile phase was a mixture of water: acetonitrile (50:50) with a flow rate of 0.5mL/min. The UV detection was performed at 360nm. The method was validated in accordance with the current ICH guidelines in terms of linearity, limit of detection, limit of quantification, precision, accuracy, recovery and system suitability. The retention time for piroxicam was 2.55 min. The calibration graph was linear in the concentration range 5-90�g/mL. The assay proved to be sensitive, specific and reproducible. The method was applied for the determination of piroxicam in tablets.
Study on n-heptane Conversion Over Ni-HZSM-5 Zeolite Catalysts
Authors: Asaftei Iuliean Vasile , Lungu Neculai Catalin , Sandu ion , Ignat Maria
Published: February 2020

The conversion of n-heptanes by the chromatographic pulse method in the temperature range of 673 - 823K on the MFI zeolites modified by ion exchange with Ni(NO3)2 aqueous solutions was studied. The catalysts, HZSM-5 (SiO2/Al2O3 = 33.9), and Ni-HZSM-5 (wt. % Ni, 0.57, 1.09, 1.34,) having different acid strength distribution exhibit a conversion and a yield of aromatics depending on temperature and metal content. The highest selectivity for n-heptanes aromatization was obtained on the catalyst Ni3-HZSM-5 (wt. % Ni 1.34) at 823K. The metal actions and the acidic properties of zeolites have an important effect on the aromatization of n-heptanes.
Multivariate Statistical Analysis Regarding the Formulation of Oxicam-Based Pharmaceutical Hydrogels
Authors: Suta Lenuta Maria , Tudor Anca , Sandulovici Colette Roxana , Stelea Lavinia , Hadaruga Daniel , Mircioiu Constantin , Balint Germaine Savoiu
Published: February 2020

In this paper, it was analysed the influence of formulation factors over obtaining oxicam hydrogels, using the statistical analysis. Data analysis and predictive modeling by multivariate regression offers a large number of possible explanatory/predictive variables. Therefore, variable selection and dimension reduction is a major task for multivariate statistical analysis, especially for multivariate regressions. The statistical analysis and computational data processing of responses obtained from different pharmaceutical formulations, via different experimental protocols, lead to the optimization of the formulation process. It was found that the most suitable pharmaceutical formulations based on oxicams with the possibility of rapid release contained cyclodextrin, in particular 2-hydroxypropyl-b-cyclodextrin.