bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation of prescribed medication pattern and adherence to treatment plans among breast cancer patients at KHCC
Authors: Zakaraya, et. al. Zainab
Published: January 2025

Adherence to treatment plans as per the prescribed medication pattern is essential to ensure better treatment outcomes. However, unfortunately, a large sum of patients often disregards this area and tend to show non-compliance to this behavior, leading towards worst treatment scenarios. The current work is dedicated to the evaluation of prescribed medication patterns and adherence to treatment plans among breast cancer patients. The study is designed on a survey approach. The study sample involved 80 participants (55 breast cancer patients and 25 breast surgeons) enrolled at the King Hussein Cancer Center (KHCC) in Amman, Jordan. In order to accumulate the required data, a questionnaire was designed and sent to the respondents in KHCC. The respondents were asked to reflect on their experience and identify the primary aspects leading to non-adherence to treatment plans among patients. After separately analyzing the questionnaires’, responses sub-mitted by the patients and surgeons, it was noted that patients consider psychological and social factors to be the primary cause of non-adherence behavior, whereas the surgeons attributed this behavior as a result of medication side effects and the complexity of treatments. Hence, it has been concluded that consideration must be paid to alleviating the aspects leading towards these causes so as to ensure patients’ maximum par-ticipation in their medication plans and augment the efficacy of therapies.
Experimental and numerical analysis of the asymmetric flat rolling process of square section bars
Authors: Ali, et. al. Ahmed Hasan
Published: January 2025

This paper analyzed the asymmetric flat rolling process of square section bars by testing experiments and finite element simulation methods. The impacts of the rate of roll diameter, decrease in altitude, and rota-tional speeds of the rolls on the width of cross-section and the curl radii at the leaving point of deformation for the brass and aluminum bar materials were investigated. Furthermore, the asymmetric rolling process of square section bars was simulated using ABAQUS commercial software. A great convergence was demon-strated among the findings forecasted by the FEM simulation and the experimental findings. It was found that by increasing the rate of rolling diameter, the curl radius and the width of the bar cross-section at the exit have been increased, and the roll speed has a insignificant impact on the width and the curl radius of the rolled bar.
A study of durable and reliable reactive powder concrete containing rice husk fibers
Authors: Qasim, et. al. Rafal Mohanad
Published: January 2025

Natural fibers have seen a surge in popularity over the past decade as a direct response to the growing num-ber of people who are concerned about the environment. The use of natural fibers has many advantages, including their low cost and their little impact on the environment. Rice husk is a byproduct of milling rice and is frequently regarded as a waste product by many people. However, it has a number of possible appli-cations, one of which is the use of its natural fibers in the production of bio-composites. In this paper, ex-perimental work was carried out to study the effect of Rice Husk Fibers with a volume fraction of one per-cent on the properties of Reactive Powder Concrete (RPC), utilizing various temperatures curing for four hours due two days after hardening the sample directly, and the optimal temperature that will give the high-est strength will be adopted to study the effect on some mechanical properties. Rice Husk Fibers were added to the RPC mixture at a volume fraction of one percent. These characteristics include the compressive strength, dry density, and slump of the material. According to the findings, the compressive strength of the RPC grew by 7.4%, while the dry density reduced by 0.69 % after being heated to 60 °C for 28 days. On the other hand, the RPC's workability decreased by 5.62 % when compared to the reference mixture.
Sustainability and environmental attitudes towards specific problems in Latin-American university students
Authors: Limo, et. al. Fernando Antonio Flores
Published: January 2025

University sustainability is a notion with tremendous transformative potential. Knowledge is essential to understand how colleges communicate it to their students in order to assess their potential for transfor-mation. The objective of this study was to assess the level of training in sustainability and associate it with environmental attitudes towards specific problems of university students in Latin-american. Through a quan-titative, correlational and cross-sectional design, two scales were applied to measure the study variables. The population consisted of 3456 university students from 15 public and private universities in Latin-american. Using the simple random probability sampling method with a confidence level of 95% and a margin of error of 5%, the sample consisted of 383 university students. It was found that there was a highly significant rela-tionship between training in sustainability and the environmental attitude towards specific problems of uni-versity students in Latin-american. Universities not only have an impact on the improvement of the quality of life of the university community, but they should also try to intervene in the spaces under a sustainable approach, understanding that students should be the main actors for environmental care.
Pushover analysis of reinforced concrete structures applied to blast load using different plastic hinge models
Authors: Dawood Asher S. , Attiyah Ali N.
Published: January 2025

The current work developed a modified pushover method using the Dynamic Load Factor DLF concept to give reasonable results compared to the more complex and time-consuming method (i.e., the non-linear time history method). A charge of 100 kg TNT is assumed to explode at different stand-off distances to cover the three blast design ranges of the (UFC 340-02) Code. The values of (DLF) were checked by applying them to the value of the blast load at the stand-off distances range between (10-70m). The results of the modified pushover method approached that of nonlinear time history with differences not exceeding (11.8%) and (4%) for maximum displacement and shear force, respectively. The DLF was suggested to be constant and equal (2.5) for the (high-pressure) design range and (1) for the (very-low pressure) design range. A formula was proposed for the (low-pressure) design range to simulate the descending values from (2.5) to (1). The prior plastic hinge models proposed by other researchers (Hawraa 2019 and Samer 2020) were used to ex-plore the more realistic structural response to blast loads compared to the standard model of ASCE41-17. Both models of the plastic hinge demonstrated a Collapse Prevention (CP) performance at the (high-pressure) design range. However, the ASCE model indicated that more columns failed in this range. Consid-ering the ASCE 41-17 and proposed approaches, the building performance at the (low-pressure) design range corresponds to the CP and Immediate Occupancy (IO) categories. Some plastic hinges were found when using the proposed plastic hinge model, but the number was nearly identical to that obtained using the ASCE method. The structure did not go beyond the elastic behavior if the proposed plastic hinge model is used in the (very low-pressure) design range. In the same design range, the structure performance lies within the (IO) category concerning the ASCE model. Generally, the suggested plastic hinge approach has been deemed sturdy due to being developed using the blast load and considered more dependable than those of ASCE41-17, which is acceptable for seismic events.
Preparation of biodegradable polymer nanoparticles stabilized with the poly (vinyl alcohol)-sodium dodecyl sulfate mixture: Effect of the lactide/glycolide molar ratio
Authors: Alhawarin Jibril Ibrahim , Alqasaimeh Muawia , Manasreh Waleed Atef
Published: January 2025

Abstract: This study examines the effects of the lactide/glycolide molar ratio on the synthesis of polymeric nanoparticles using a PVA-SDS stabilizers solution. PLA was obtained with a ratio of 100/0, while PLGA was synthesized at ratios of 88/12 and 64/36. Polymerizations employed ROP at 130°C with stannous oc-tanoate and 1-dodecanol as catalysts. Polymerizations were conducted through ring opening at 130°C with stannous octanoate and 1-dodecanol as catalyst and co-catalyst. Characterized polymers were used to pre-pare emulsions stabilized with polyvinyl alcohol (15 g/L) alone or mixed with sodium dodecyl sulfate of various molecular weights (MW=13-23, 31-50 and 85-124 KDa). These emulsions were stored in phos-phate-buffered saline for 28 days at 37.4°C. Colloidally stable emulsions were achieved using different poly (vinyl alcohol) concentrations, with the lactide/glycolide molar ratio influencing particle diameter. The elec-trostatic stabilizer formed by the poly (vinyl alcohol)-sodium dodecyl sulfate mixture demonstrated .Superior stabilization compared to poly (vinyl alcohol) alone, representing a novel finding. Moreover, the poly (vinyl alcohol-sodium dodecyl sulfate) mixture showed reduced water diffusion into the nanoparticles compared to poly (vinyl alcohol) alone, as evidenced by molecular weight and pH measurements. Addition-ally, the degradation of poly (lactic acid) and poly (lactic-co-glycolic acid) films was investigated; pH measurements in the immersed solutions showed that the degradation was increased with higher glycolide content.
The effects of social media digital channels on marketing and expanding the industry of e-commerce within digital world
Authors: Khrais Laith T. , Gabbori Dina
Published: January 2025

The primary research question investigated was: What is the effect of social media channels on e-commerce expansion and marketing by Jordanian firms? The specific objectives included examining social media channels' effect on Jordanian companies' marketing and exploring social media's impact on Jordanian e-commerce expansion. To achieve the research goal, a quantitative method was used in which fifty social media managers of Jordanian firms were recruited and surveyed. A key result from the analysis conducted was that social media enables word-of-mouth expression by users regarding certain brands that positively and significantly increase the marketing effect of the firms. The other result noted from the analysis is that an increasing number of loyal followers can eventually lead to reduced e-commerce of firms if they fail to align the products and services with customers' interests. One limitation of this research was a small sample, which reduced the generalization of the results. One recommendation from this research is that Jordanian firms should create entertaining and engaging social media posts that ensure customers can share their posi-tive experiences using specific products, leading to significant marketing impact.
Lactic acid production a bibliometric study
Authors: Cárdenas-Arias, et. al C. G.
Published: January 2025

Bibliometrics is a documentary analysis tool that is positioning itself as a support to know and understand the study status of a specific topic. In this case, the VOSviewer software was used to determine the evolu-tion of lactic acid production, carried out through a programmed search with the VOSviewer application, which allowed a clear and reliable bibliographic review for the topic development under study, which made possible to obtain enough material to know who, where and in what year have published about the latest advances in the production of lactic acid. The database used was Scopus, with the search equation “lactic acid” and production and “natural sources”.
Hybrid cat swarm optimization with war strategy optimization for solving optimization problems
Authors: Khaleel Sameerah , Zaher Hegazy , Saeid Naglaa Ragaa
Published: January 2025

The user-friendly and adaptable nature-inspired meta-heuristic algorithms have significantly contributed to their increasing appeal across several scientific fields, including computer science, mathematics, artificial intelligence, and operations research. The algorithms are constructed upon the core notions of exploration and exploitation. This study presents a fresh technique to optimizing issues by utilizing the War Strategy Optimization (WSO) method. The recommended technique involves utilizing the WSO algorithm in con-junction with the Cat Swarm Optimization (CSO) algorithm. The term used to describe this algorithm that combines different methods is C-WSO. The implementation of swarm intelligence approaches has led to the improvement of the capabilities of both algorithms.A total of fifty benchmark test functions were adopted to assess the efficacy of the newly proposed C-WSO approach. Definite functions exhibited multimodality, while others were unimodal, and they were executed across diverse dimensions. Our investigations revealed that the C-WSO algorithm outperformed the original WSO approach. The method's performance has been assessed using a diverse range of measures, including the median, mean, and standard deviation of the fitness function values. Repeated evidence has exposed that the C-WSO approach surpasses the WSO algorithm in terms of effectiveness, creating it a viable and practi-cal choice for solving complex optimization problems.
Nyelvhasználat a Magyarországon élő kínai bevándorlók körében: az anyanyelv kérdése
Authors: Ésik Szandra
Published: January 2025

A Központi Statisztikai Hivatal előzetes adatai szerint a Magyarországon tartózkodó kínai állampolgárok száma 2024. január 1-jén 21 150 fő (10 950 férfi, 10 200 nő) volt. Az összesített adatokat nézve ennél csak az Ukrajnából (27 400 fő) és a Németországból (23 300 fő) érkezők vannak többen (KSH, 2024a). A nagyszámú kínai bevándorló szükségessé teszi, hogy a kutatók figyelemmel kísérjék a kínai migrációs folyamatok mozgatórugóit és fejleményeit, vizsgálják a kínai bevándorlók életkörülményeit, a beilleszkedés menetét. Mivel Kínából aktív korúak, diákok, illetve kisgyermekes családok is érkeznek hazánkba, a kínai közösség igen sokszínű, ezért a kínai migrációt számos szempontból lehet vizsgálni.
Kutatásomban iskoláskorú gyermekek (általános iskola 5. osztálytól középiskola 12. osztályig), felnőttek és szülők körében végzett kérdőíves adatgyűjtésre, valamint interjúkra támaszkodva igyekszem feltárni a Magyarországon élő kínai bevándorlók nyelvhasználatának bizonyos jellemzőit. A vizsgálat itt ismertetett szegmense bemutatja, hogy a Magyarországon élő kínai bevándorlók hogyan viszonyulnak anyanyelvükhöz. Az anyanyelvhez való viszonynak kulcsfontosságú szerepe van az identitás formálódásában és kifejezésében, a nyelvtanulásban, a nyelvmegtartásban és a nyelvvesztésben, végül pedig a társadalmi beilleszkedés egész folyamatában. A témának ugyanakkor nemzetközi létjogosultsága is van, hiszen a kínai migráció globálisan meghatározó jelenség. A tanulmány célja ugyanakkor, hogy felhívja a figyelmet a kínai migráció vizsgálatának fontosságára, bővítve ezzel a hazai sinológiai munkák horizontját, hiszen Magyarországon mindeddig csak elenyésző számú kutatás vállalkozott erre.
Blokkosodás irányában: migrációs és népesedési diskurzusok a nyolcvanas években (1. rész)
Authors: Melegh Attila
Published: January 2025

Az 1980-as évektől kezdődően nőtt a vándorlás intenzitása, és ez kihívás elé állította a népesedésről való gondolkodást, mivel a népesedési diskurzusok és elméletek korábban főképp a termékenységre összpontosítottak, és ambivalens módon kezelték a migrációt. A népesedési és migrációs diskurzusok újszerű összekapcsolása révén azt látjuk, hogy valamennyi kulcsfontosságú diskurzus (malthusi, demográfiai átmenet, szocialista modernizáció, konzervatív, etnikainarodnik, revitalizációs és fejlesztési) szükségszerűségnek tekintette a migrációt, ugyanakkor amellett is érvelt, hogy a vándorlást fékezni és szelektálni kell. Az 1980-as évektől induló időszakban a migráció kérdése átrendezte a mentális térképet, és egy, a piaci nyitást szorgalmazó, illetve egy migránsellenes, szuverenista blokk irányába tolta az egyes népesedési diskurzusokat.
Family, School And Society: An Integrated Approach To Cambating Childhood Obesity
Authors:   Perm State Medical University named after Academician E. A. Wagner, Khamkhoeva Lema , Vitko Anastasiia ,   Altai State Medical University of the Ministry of Health of the Russian Federation, Zaitsev Alexey ,   Volga Region Research Medical University, Sayfutdinova Lilia ,   Bashkir State Medical University, Demirdzhaeva Emine ,   Crimean Federal University named after V I. Vernadsky
Published: January 2025

In the contemporary world, obesity among children and adolescents is becoming an increasingly critical public health issue. Statistical data from recent years indicate a significant rise in the prevalence of childhood obesity worldwide, necessitating immediate prevention and treat-
ment measures. The authors of the present review focus on the importance of early intervention and targeted assistance. Based on the analysis of numerous studies, the paper discusses various methods of preventing and treating childhood obesity, including programs for proper
nutrition, increasing physical activity, as well as the role of family and school environments in shaping a healthy lifestyle. The importance of individualized dietary programs and psychological support is emphasized, which contribute to a more effective reduction in Body Mass Index and improvement in overall health. The authors also highlight the contribution of pharmacotherapy to the comprehensive treatment of obesity in children, noting the potential use ofdrugs such as metformin and liraglutide, while also underlining the need for further research to assess their long-term safety and efficacy. In conclusion, the article emphasizes the necessity of a comprehensive approach to the problem of childhood obesity, including the integration of medical, psychological, educational, and social strategies, as well as the importance of global and local collaboration in developing and implementing prevention and treatment programs for obesity among children.
Russian Cargo Traffic in New Conditions: Opportunities and Restrictions
Authors: Turaeva M. O.
Published: January 2025

The article shows changes that affected cargo operations due to current transformation of the global situation, anti-Russia sanctions and replacement of key economic partners of Russia. The author analyzes accessible data of cargo traffic in home and international lines and explains possible underestimation of certain figures. Restrictions were investigated that hinder the development of some types of traffic, cause losses in cargo operations and shortage of resource capacity, in particular in moving-in and -out. The article shows reasons for impeding further intensive increase in cargo operations. The author studies such restrictions as distance of the route, fuel cost, nature and climatic conditions, the level of road network development, necessity to use transit communication in certain Russian regions, rising rates of utilization duties, high interest rate, risk of trucking companies’ leaving for the green zone, poor experience in using and maintaining Chinese cargo equipment that changed European trucks. The article assessed the dynamics of traffic and prospects of international transit in conditions of further scenario volatility, on the one hand and high adaptive capacity of national economic system to changing conditions and crises, on the other.
Casos de manejo sostenible de concesiones forestales maderables en la Región Madre de Dios, Perú
Authors: Sabogal César , Kroll Nelson , De Dea Vittorio , Pacheco Enrique
Published: January 2025

In Peru, informal use of the Amazon forests predominates, in violation of the regulatory measures that regulate forest harvesting activities. Despite a series of factors that limit or hinder the application of sustainable forest management (SFM), there are positive experiences that show high standards in the management practiced over the years. The objective of this article is to show the level reached by some successful forest management initiatives in the Madre de Dios Region and how they contribute to improving the model of forest concessions for timber purposes (CFM) in the country. This model, introduced into Peruvian legislation in the 2000s, currently has more than 9.7 million hectares under concession, although the CFM that are operational cover only 2.4 million hectares. Madre de Dios is the region with the largest area of certified forest in the country, with six CFM totaling 601,535 ha. Based on a study funded by the USAID Pro-Bosques Project, two initiatives managed by concessionaire companies in this region were selected for systematization: Consolidado Maderacre S.A.C. and Consolidado Forestal Otorongo S.A.C., and one by a native community (CN): CN Bélgica. The methodology included field visits in which a guide was applied to describe the various aspects of interest for systematization, as well as interviews with various stakeholders. The results are described for each of the three initiatives, covering general information on the case, planning and implementation of forest management, environmental aspects, monitoring and research, economic and sociocultural aspects, and lessons learned. Based on the experiences of the three cases with high standards in their forest management practices, the authors highlight how they contribute to keeping the forest standing with its productive and ecosystem functions, and the challenges they face or perceive, to finally offer some guidelines that can help improve the viability of the current CFM model and take advantage of the opportunities to introduce reforms that help its scaling.
Aproximación dendroecológica y caracterización anatómica y física de la madera juvenil de Araucaria angustifolia de Oxapampa, Perú
Authors: Romero Jordan , Bozovich-Granados Milo , José Sousa Nilton , Chavesta Manuel , Montenegro Rolando
Published: January 2025

The study of tree growth in forest plantations for timber use must be complemented by the description of wood characteristics to serve both foresters and wood technologists. Studies based on growth rings allow for the acquisition of growth records in diameter, height, shape, and volume with annual resolution, facilitating the assessment of their relationship with environmental factors. This is crucial for thinning and harvesting decisions in forest plantations. Evaluating differences in wood characteristics in axial and radial directions provides valuable information for analyzing their optimal potential use. This study evaluated the growth of Araucaria angustifolia (Bertol.) Kuntze using dendroecological techniques. Additionally, wood anatomy and basic density were examined at four axial positions and three radial levels as quality indicators. Stem analysis revealed that CAIDBH ranged from 1.72 to 2.33 cm; MAIDBH ranged from 1.70 to 1.99 cm. The climatic variable that best explains the radial growth variability was precipitation, with a R2 of 83.82 %. A higher basic density, tracheid length, and tracheid wall thickness were found near the base and the bark. Based on these findings, A. angustifolia demonstrated promising growth and wood quality under local conditions, such as those in Oxapampa, for timber use.
Fabrication of Mastic Gum Resin Tethered Phospholipid Nanocarriers for the Evaluation and Enhancement of Anti-inflammatory and Anti-bacterial Effects
Authors: Selvaraj Karthikeyan , Lee Sang-Jin , Song Keun-Bae , Yoo Bong-Kyu , Karuppaiah Arjunan
Published: January 2025

Introduction:

The objective of the present study was to improve the anti-inflammatory and antibacterial
activities of mastic gum resin (MGR). MGR was loaded into a phospholipid nanocarrier with or without
partially hydrolyzed ginsenoside, followed by dispersion into distilled water.

Method:

The phospholipid nanocarrier dispersion showed significantly enhanced in-vitro release, porcine skin/
intestine permeation, and retention. When the ratio of the MGR versus partially hydrogenated ginsenoside
reached 1:1 w/w in the nanocarrier composition, the in-vitro release increased 54.8-fold compared to the MGR
powder suspended in the release media.

Results:

Permeation of the nanocarrier dispersion through the porcine skin and intestine increased 160-fold
and 42-fold, respectively, compared to permeation of the MGR powder suspension. Furthermore, the nanocarrier
dispersion reduced NO production and iNOS mRNA expression in the LPS-stimulated RAW264.7 cells.
MIC and MBC of the nanocarrier dispersion against P. gingivalis were 4.11 ± 1.17 and 8.22 ± 2.35 μg/mL, respectively.

Conclusion:

In conclusion, the anti-inflammatory and antibacterial activities of MGR were remarkably enhanced
when the MGR was loaded into the nanocarrier with partially hydrolyzed ginsenoside.

conclusion:

Anti-inflammatory and antibacterial activities of MGR were remarkably enhanced when the MGR was loaded into the nanocarrier with partially hydrolyzed ginsenoside.
Trafficking of Muscarinic 1 Acetylcholine Receptor Regulated by VPS35 in Alzheimer's Disease
Authors: Wang Chen , Chen Xi , Yu Zhenzhen
Published: January 2025

Introduction:

Muscarinic 1 acetylcholine receptor (M1AChR) is a member of the Gprotein-
coupled receptor superfamily, with the dysfunction being linked to the onset of
Alzheimer's Disease (AD).

Aims:

Retromer complex with Vacuolar Protein Sorting-35 (VPS35) as the core plays an important
role in the transport of biological proteins and has been confirmed to be closely related to the
pathogenesis of AD. This study was designed to determine whether VPS35 could affect the trafficking
mechanism of M1AChRs.

Method:

The interaction between VPS35 and M1AChR was studied by co-immunoprecipitation
method, and the recycling of M1AChR influence by VPS35 was analyzed using biotinylation technology.

Results:

It was found that VPS35 affected the localization of M1AChR on the cell membrane by
regulating intracellular M1AChR transport, thus controlling the M1AChR-mediated cholinergic
signaling pathway.

Conclusion:

The findings presented here provide a potential pathogenesis and pathway for the
treatment of AD.

other:

none
The Relationship between Soluble Endoglin Levels, Endothelial Nitric Oxide Synthase Levels, and Thrombocyte Count and the Onset of Preeclampsia
Authors: Aladin Aladin , Yusrawati Yusrawati , Karmia Hudila Rifa , Azwan Reyhan Julio , Sausan Ramya
Published: January 2025

Background

Early-onset preeclampsia, or EOP, depicts clear placental abnormalities (placental factor), whereas late-onset preeclampsia, or LOP, does not. However, previous studies found varying results on the role of proangiogenic and antiangiogenic factors, including soluble endoglin (sEng), endothelial nitric oxide synthase (eNOS), and thrombocytes in both types of preeclampsia.

Objective

This study aimed to determine the relationship between sEng levels, eNOS levels, and thrombocyte count with the onset of preeclampsia.

Methods

A cross-sectional study was conducted on subjects diagnosed with severe preeclampsia receiving treatment at Dr. M. Djamil Hospital Padang from December, 2023, until March, 2024. After meeting the inclusion and exclusion criteria, maternal plasma concentrations of sEng and eNOS were determined by ELISA, while thrombocytes were measured by a complete blood count.

Results

A total of 40 women with EOP and 40 with LOP participated in this study. This study found no difference between the two groups in eNOS (p = 0.303) and sEng (p = 0.468). However, thrombocyte count differed between early and late-onset PE (p = 0.001). Spearman correlation analysis found a significant correlation between eNOS and sEng (p = 0.033), eNOS and thrombocyte count (p = 0.026), and thrombocyte count and sEng (p = 0.032).

Conclusion

This study found no difference in proangiogenic and antiangiogenic factors between EOP and LOP, which suggests that a subset of patients with LOP also has an imbalance in the concentrations of proangiogenic and antiangiogenic factors in maternal plasma. However, lower thrombocyte counts in EOP reflect a more severe disease course. This study also found a correlation between eNOS and sEng, eNOS and thrombocyte count, and thrombocyte count and sEng in preeclampsia.
Synthesis of Novel Cyclic Imide-containing Thiazole and Benzothiazoles for Antimicrobial Evaluation and Computational Docking Studies
Authors: Pawar Smita , Kale Amol , Jadhav Srushti , Shendge Shital , Shinde Nilesh , Lande Rushikesh , Kapase Pratik
Published: January 2025

Background:

Many compounds with thiazole, benzothiazole, and cyclic imide have been found to exhibit potent antimicrobial activity, such as Cefotaxime, Moiramide, Ri-tonavir, etc.

Aims:

As per the aim of this study, the cyclic imides with thiazole and benzothiazole moiety were designed and synthesized.

Objectives:

Literature findings suggest the potential antimicrobial properties of thiazole and benzothiazole, which inspired us to design and synthesize imides with succinic anhydride, phthalic anhydride, and maleic anhydride.

Methods:

Three series of synthetic compounds were synthesized i.e. substituted 1-(4-(p-tolyl)thiazol-2-yl)pyrrolidine-2,5-dione (SI 1-6), 2-(4-phenylthiazol-2-yl)isoindoline-1,3-dione (PI 1-6), and 1-(benzo[d]thiazol-2-ylamino)-1H-pyrrole-2,5-dione (MI 1–5) and characterized with IR, NMR, Mass spectroscopy. All synthesized derivatives were evaluated to check the an-timicrobial properties against Gram +ve, Gram -ve bacteria, and fungi species by determining the zone of inhibition and minimum inhibitory concentration. Docking was carried out to check binding affinities with targets ‘DNA Gyrase and Penicillin Binding Protein 3’.

Results:

Zone of inhibition showed that all the synthesized compounds are active against bac-teria and fungi. Compound SI-4 showed a maximum zone of inhibition. Most of the com-pounds showed MIC at 6.25 and 12.5 μg/ml. A docking study revealed that compounds PI-4 and PI-2 showed good dock scores towards DNA Gyrase and Penicillin Binding Protein 3, respectively.

Conclusion:

All synthesized compounds showed significant antimicrobial properties. The anti-microbial evaluation showed that compounds SI-4, PI-,2, and MI-1 possess good antimi-crobial activity. Electron withdrawing substitutions may enhance the antimicrobial property.
Histone Deacetylase Inhibitors Promising Therapeutic Target for Liver Diseases
Authors: Sharma Akansha , Sharma Uma , Gupta Sangeetha
Published: January 2025

Despite enormous advances in the current treatment strategies, liver diseases are associ-ated with high mortality. It is critical to discover novel drug targets for developing effective thera-pies. Histone deacetylase (HDAC) inhibitors have emerged as a promising therapeutic approach for the treatment of various liver diseases. The use of histone deacetylases and their inhibitors to treat a variety of liver illnesses has been thoroughly reviewed using suitable keywords and key phrases as search terms within scientific databases like Web of Science, Google Scholar, PubMed, and other web sources, and data was collected and sorted from the literature spanning from 1990 to 2023, providing an overview of the role of HDACs in liver diseases together with the evidence of the therapeutic effects of HDAC inhibitors in various liver diseases. HDACs are enzymes that play a crucial role in regulating gene expression by deacetylating histone proteins, which can alter chro-matin structure and thereby regulate gene expression. Dysregulation of HDAC activity is associated with liver diseases, including Hepatocellular carcinoma (HCC), non-alcoholic fatty liver disease (NAFLD), hepatitis B virus (HBV), and hepatitis C virus (HCV) infections, etc. as implicated in many studies both in vitro and in vivo. This review summarizes the prevalence of liver diseases and how their impact is significant. We highlight the crucial role of histone deacetylases (HDACs) in liver diseases. In addition, by targeting various mechanisms, HDAC inhibitors have shown promise as novel hepatoprotective agents. These inhibitors can have therapeutic effects in different liver dis-eases. They can induce cell cycle arrest, promote apoptosis, improve insulin resistance, address he-patic steatosis, and enhance differentiation in hepatocellular carcinoma (HCC) cells. The multifac-eted approach of HDAC inhibitors offers potential for innovative treatments in liver diseases.
Utility of Serum-Based Markers to Predict Severity, Histological Activity,
and Rehospitalisation in Ulcerative Colitis
Authors: Gonde Apul , Samarth Amol , Mishra Sanat , kumar Vinay , Gajare Aditya , Shirahatti Karthik
Published: January 2025

Introduction:

Inflammatory Bowel Disease (IBD) comprises ulcerative colitis
(UC) and Crohn’s disease (CD). Serum-based non-invasive biomarkers are suggested for
endoscopic and histological healing in clinical practice.

Aims:

The aim of this study was to investigate the utility of serum-based markers to predict
severity, histological activity, and rehospitalization in ulcerative colitis.

Materials and Methods:

This was a cross-sectional study that was performed in a tertiary
care center from October 2022 to March 2023. Diagnosis of ulcerative colitis on the basis
of clinical history, imaging findings, flexible sigmoidoscopy/colonoscopy findings, and histopathology reports and agreed to participate were included. All the data, including blood
parameters, were analysed.

Results:

C Reactive Protein (CRP)/albumin (AUC 0.821; 95% CI: 0.732 to 0.891, cut off
point of >2.57), (AUC 0.875; 95% CI: 0.794 to 0.933, cut off point of >4.13) was the best
predictor for correctly predicting endoscopic severity (UCEIS) and active histological inflammation and also a good predictor of re-hospitalization in the last 6 months (AUC 0.814;
95% CI: 0.724 to 0.885, cut off point of >6.34) as compared to red cell distribution width
(RDW)/albumin (AUC 0.598; 95% CI: 0.495 to 0.695), (AUC 0.537; 95% CI: 0.434 to
0.637), which was non-significant. RDW/Albumin (AUC 0.793; 95% CI: 0.701 to 0.868)
also predicts 6-month rehospitalization significantly but less as compared to CRP/Albumin.

Conclusion:

In ulcerative colitis, the CRP/ALB ratio was a strong predictor of endoscopic
severity, histologic disease activity, and rehospitalization in 6 months. It can be used to predict treatment response and as an indirect biomarker for mucosal healing.
Diagnostic Biochemical Changes Identified in a Cohort of Patients with Coronavirus-19 (COVID-19) Disease
Authors: Alsamarai Mohamed Almoustafa , Avsar Aysenur Kayabas , Alobaidi Amina Hamed , Alsamarai Abdulghani Mohamed
Published: January 2025

Backgroun:

SARS-CoV-2 infection was associated with inflammatory, metabolic, haematological,
and immunological changes, which contributed to the increase in morbidity and mortality.

Objective:

To illustrate changes in some biomarkers (ESR, ferritin, CRP, D. dimer, ALT, AST, creatinine,
and urea) during COVID-19 and their predictive value in the diagnosis of SARS-CoV-2
infection, especially in rural and urban areas in which sophisticated tests were not available.

Materials and Methods:

The study includes 154 COVID-19 patients with positive RT-PCR. Sixty
age and sex-matched individuals were included as controls. The study was conducted during the
period from 23rd July 2021 to the end of December 2021. The subjects with a history of liver diseases,
pregnant women, an age of less than 18, and chronic renal failure were excluded. The informed
consent was taken from each individual before their enrolment in the study. The study was performed
in compliance with the World Medical Association Declaration of Helsinki. Venous blood
samples were collected from both groups and tested for determination of creatinine, urea, and alanine
aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), D dimer,
ferritin, and C-reactive protein (CRP) using a Mindray BS 240 chemical auto-analyzer.

Results:

The mean serum values were significantly higher (P= 0.01 – 0.001) in COVID-19 patients
as compared to matched controls for creatinine, blood urea, ALT, AST, ESR, LDH, D- dimer, ferritin,
and CRP. In addition, the mean serum levels of ALT, AST, ESR, LDH, D-dimer, ferritin, and
CRP were higher than the values of normal ranges. Although, creatinine and urea mean serum values
were significantly higher in COVID-19 patients, their mean values were within the normal range
values. ESR was highly significantly (p < 0.001) correlated with ALT, AST, LDH, urea, ferritin, and
CRP. While LDH was highly significantly correlated with creatinine, urea, ESR, ferritin, and CRP.
Also, D. dimer was significantly highly correlated with ferritin, and CRP. Serum ferritin was highly
significantly correlated with creatinine, urea, ESR, LDH, D. dimer, and CRP. While CRP was highly
significantly correlated with creatinine, urea, ESR, LDH, D. dimer, and ferritin.

Conclusion:

ESR, CRP, Ferritin, D. dimer, LDH, AST, ALT, urea, and Creatinine levels in venous
blood were significantly elevated in COVID-19 patients compared with controls. Sex- influenced
serum levels of C-reactive protein, creatinine, and urea in this study cohort. Serum levels of tested
biomarkers may be useful in the diagnosis of COVID-19 in primary healthcare centres, especially in
rural areas in developing countries.
La acción soberana: alternativa a la ineficacia estatal sobre seguridad ciudadana en México
Authors: Ordóñez Joaquín , Guadarrama Adriana
Published: January 2025

Introducción: En México el problema de la inseguridad pública amenaza la paz y el bienestar de las personas, situación que ha generado diversas formas de reacción de la población ante la percepción de incumplimiento de la función estatal en materia de seguridad ciudadana,en la que, se reconsidera la soberanía de las personas y la potencial justificación de aplicarla en casos de ausencia estatal para afrontar la inseguridad ciudadana, lo cual contrasta con el mandato constitucional de hacerse justicia por sí mismo y a su vez con la ineficaciaestatal para cumplir con esa función. Objetivo: determinar si la soberanía inherente a las personas es una alternativa viable y justificada para afrontar la inseguridad. Metodología: revisión exclusivamente teórica, sistematizada con datos cuantitativos y cualitativos que permitieron contrastar los hallazgos de los estudios realizados a la teoría y la doctrinaanalizada e interpretada, de lo que resultaron datos relevantes que sugieren la posibilidad de que la ineficacia estatal pueda ser complementada con la acción soberana de las personas. Conclusión: el Estado no cumple cabalmente con esa función de seguridad por lo que el juicio democrático ha justificado la solución momentánea a los casos de inseguridad.
Ураження нирок при артеріальній гіпертензії (діагностичні й терапевтичні аспекти)
Authors: Коваль С.М. , Рєзнік Л.А. , Старченко Т.Г. , Литвинова О.М.
Published: January 2025

Одним з найбільш частих і тяжких ускладнень артеріальної гіпертензії є ураження нирок з розвитком хронічної хвороби нирок. У даному огляді подані діагностичні критерії хронічної хвороби нирок і наведений алгоритм оцінки ризику її прогресування до термінальної стадії; проаналізовані особливості перебігу артеріальної гіпертензії в пацієнтів із хронічною хворобою нирок і наведені основні патогенетичні механізми прогресування гіпертензії в цієї категорії хворих. Особливу увагу приділено проблемі ефективного лікування хворих. Показано, що поліпшення контролю рівня артеріального тиску в осіб із хронічною хворобою нирок призводить до зниження ризику розвитку серцево-судинних подій, зменшує показник серцево-судинної та загальної смертності. Підкреслено, що рання інтенсивна терапія пацієнтів з артеріальною гіпертензією та хронічною хворобою нирок сприяє як профілактиці несприятливого перебігу самої гіпертензії, так і уповільненню прогресування уражень нирок. У статті подані рекомендації щодо контролю артеріального тиску і його цільових рівнів при лікуванні різних категорій хворих на артеріальну гіпертензію з хронічною хворобою нирок. Розглянуті переваги застосування різних класів антигіпертензивних препаратів при лікуванні цієї категорії хворих. Показано, що більшість пацієнтів з артеріальною гіпертензією та хронічною хворобою нирок потребують комбінованої антигіпертензивної терапії. Наведені додаткові переваги застосування інгібіторів натрійзалежного котранспортера глюкози 2-го типу і нестероїдного антагоніста мінералокортикоїдних рецепторів фінеренону при лікуванні цієї категорії хворих. У статті подана поетапна схема лікування хворих на артеріальну гіпертензію з хронічною хворобою нирок. Також у статті наведені власні дані щодо частоти і вираженості ураження нирок у хворих на артеріальну гіпертензію. Наголошено на необхідності проведення регулярного скринінгу хворих з артеріальною гіпертензією на наявність хронічної хвороби нирок з метою її раннього виявлення і проведення ефективної немедикаментозної та медикаментозної терапії.
Підготовка до командної роботи фахівців з охорони здоров’я у процесі безперервного професійного розвитку: міждисциплінарний підхід
Authors: Білоусова Н.А. , Сіренко Ю.М. , Несукай В.А. , Лобач Л.Є. , Яковенко Л.І. , Сімагіна Т.В. , Лучинська Ю.О. , Кожухарьова Н.А. , Долженко М.М. , Соколов М.Ю.
Published: January 2025

Щорічне зростання витрат на охорону здоров’я призвело до впровадження ціннісно-орієнтованих підходів у зарубіжних країнах. Ці дії передбачають співвідношення якості медичних послуг та вартості досягнення результатів лікування. На державному рівні в Україні запропоновано впровадження мультидисциплінарних підходів до надання медичної допомоги за рахунок підготовки фахівців охорони здоров’я до командної роботи у процесі безперервного професійного розвитку. Метою статті є узагальнення досвіду зарубіжних країн з питань підготовки до взаємодії в мультидисциплінарних командах у процесі безперервного професійного розвитку фахівців охорони здоров’я з подальшою імплементацією в українську систему післядипломної освіти. Матеріали та методи. Використано публікації наукових видань наукометричних баз даних Scopus, Web of Science, PubMed, міжнародні та вітчизняні нормативно-правові документи, сайти міжнародних організацій, закладів вищої освіти, освітніх порталів, навчально-тренінгових центрів. Застосовано методи систематизації, контент-аналізу, синтезу, порівняння. Результати та обговорення. Проаналізовано міжнародні й вітчизняні нормативно-правові документи. Досліджено сайти зарубіжних університетів і організацій. Визначено основні підходи до післядипломної підготовки фахівців охорони здоров’я у міжпрофесійній освіті. Виокремлено основні форми та методи міжпрофесійної освіти у післядипломній підготовці фахівців охорони здоров’я. Впроваджено міжпрофесійну підготовку в освітню траєкторію безперервного професійного розвитку лікарів різних спеціальностей, медичних сестер, фельдшерів та фармацевтів. Висновки. Визначено застосування форм і методів міжпрофесійної освіти на засадах міждисциплінарного підходу в командній роботі при підготовці фахівців охорони здоров’я. Встановлено позитивний вплив міжпрофесійної взаємодії у складі мультидисциплінарних команд на якість надання медичної допомоги. Впроваджено міжпрофесійну підготовку лікарів різних спеціальностей в освітній процес безперервного професійного розвитку фахівців охорони здоров’я.
Рекомендації Європейського товариства кардіологів ESC 2024 з лікування підвищеного артеріального тиску та гіпертензії
Authors: McEvoy John William , McCarthy Cian P. , Brouwers Sofie , Others And
Published: January 2025

No abstract
The Global Rise of Anti-Gender Movements and Feminist Resistance Strategies
Authors: Gergorić Maja , Ghosh Kusumika , Kuteleva Anya
Published: January 2025

In recent years, there has been a noticeable surge in anti-gender and anti-feminist discourses in international politics. Politicians, policymakers, and diverse societal actors in various countries challenge or reject feminist ideas and gender-related concepts, as well as support policy changes that erode the structures and institutions that have been instrumental in upholding women's rights, promoting gender equality, and protecting the rights of LGBTQ people. This special issue of Politikon: The IAPSS Journal of Political Science seeks to explore the multifaceted nature of these discourses, examining their origins, implications, and potential impacts on domestic, regional, and international levels. Additionally, it aims to identify strategies and opportunities for feminist resistance and advocacy in the face of the backlash.
Neverending 90s in Serbia
Authors: Bobičić Nađa , Petrović Vanja
Published: January 2025

Right-wing actors—conservative politicians, public intellectuals, and the Serbian Orthodox Church—have been influential in contemporary Serbia since the early 1990s, playing a formative role in its anti-gender movement. This study advances our understanding of how anti-gender mobilization draws from its local context. Drawing on Judith Butler’s concept of gender phantasm and Andrea Pető’s concept of gender as symbolic glue, this analysis examines two documents: the 1992 “Warning” resolution and Patriarch Pavle’s 1995 Christmas message. These texts enable mapping of actors and succinctly encapsulate the ideological imaginaries of the conservative elite who remain active. The ideological imaginary uniquely draws from rhetoric used to justify regional wars, serving as the phantasmic foundation of contemporary anti-gender mobilizations. Since right-wing actors operated within a contested space, the study acknowledges the unwavering feminist and pacifist left-wing opposition.
El interés de Ricardo Tapia por la bioética
Authors: Álvarez del Río Asunción
Published: January 2025

En este artículo se comenta el libro que reúne las contribuciones de Ricardo Tapia Ibargüengoitya sobre la bioética. Gustavo Ortiz, miembro del Colegio de Bioética, A.C. (como lo fue Tapia) seleccionó para el libro De neurociencias y bioética, publicado por la UNAM, el Instituto de Investigaciones Filosóficas y el Instituto de Fisiología Celular, las aportaciones más relevantes de quien fuera un gran investigador de las neurociencias, pero muy comprometido también con la reflexión y análisis de diferentes problemas bioéticos. Sobre todo de los que se relacionaban con sus prácticas y que lo llevaron a escribir en diferentes textos sobre la integridad científica, el principio y final de la vida, las adicciones, la clonación, la investigación con células embrionarias o la neuroética, por citar algunos de los temas incluidos en la obra mencionada.
Análisis anátomo-fisiológico del poema Primero sueño de Sor Juana
Authors: Olarte Casas Miguel Ángel
Published: January 2025

El poema “Primero sueño” de Sor Juana Inés de la Cruz, publicado en 1692, ha sido analizado desde diversas perspectivas: para algunos autores como el tránsito del dormir, soñar y despertar y para otros como una batalla entre el día y la noche, el sueño y la vigilia o entre la ignorancia y el conocimiento, y aunque ya previamente se han resaltado los aspectos corporales tratados por la autora en su obra, el presente trabajo se enfoca en el análisis intertextual del poema desde la concepción científica del siglo XVII al que perteneció la jerónima, inmersa en postulados neoplatónicos y herméticos, para posteriormente cotejar estos principios con el conocimiento médico actual y hasta encontrar entre estos textos, tan distantes en tiempo y sistemas gnoseológicos, una correlación entre arte y ciencia para no olvidar que la medicina es considerada de entre las ciencias la más humana.