bluuebunny/crossref_metadata_2025 huggingface dataset:
Eating disorders and social media use among college students in Japan and China: a brief cross-sectional survey
Authors: Bai Yijing , Numata Noriko , Shimizu Eiji
Published: April 2024

Background

In recent years, new forms of media-social networking services (SNS)-such as Facebook and Sina Weibo have spread rapidly. Greater SNS use has been associated with greater body dissatisfaction, which in turn, is related to greater eating disorder (ED) symptom severity. In this study, we (1) investigated the relationships between ED tendencies, SNS use intensity, and body esteem and (2) examined the mediating role of body esteem in the relationship between SNS use intensity and ED tendencies among Japanese and Chinese students.

Methods

A total of 564 Japanese and Chinese college students aged 18–22 years were surveyed on their age and BMI, including self-filling questions from the Japanese and Chinese versions of the Eating Attitudes Test (EAT-26), SNS Intensity Scale, Body Esteem Scale for Adolescents and Adults (BESAA), Patient Health Questionnaire-9 (PHQ-9), and Generalized Anxiety Disorder-7 (GAD-7) scale.

Results

The proportion of students with a score of ≥ 20 on the EAT-26 was 15.8% (Japanese, 14.7%; Chinese, 17.0%). The number of participants with scores ≥ 20 on the EAT-26 was significantly higher than ever before, both in Japan and China. Chinese students reported greater body esteem than Japanese students, as well as a stronger association of SNS use intensity with body esteem. Among Japanese students, EAT-26 scores were unrelated to SNS Intensity Scale scores but had a weak negative correlation with BESAA scores; therefore, body esteem did not mediate the relationship between SNS use intensity and ED tendencies. Among Chinese students, scores on the SNS Intensity Scale and BESAA had a weak correlation with EAT-26 scores, and SNS use intensity reduced ED tendencies through greater body esteem.

Conclusions

It is important to consider the way users engage with SNS, in addition to the SNS use intensity. Improving body esteem may reduce the risk of ED. Furthermore, it is necessary to include men in the discussion on ED in the future.
Shaping the future of preclinical development of successful disease-modifying drugs against Alzheimer's disease: a systematic review of tau propagation models
Authors: Basheer Neha , Buee Luc , Brion Jean-Pierre , Smolek Tomas , Muhammadi Muhammad Khalid , Hritz Jozef , Hromadka Tomas , Dewachter Ilse , Wegmann Susanne , Landrieu Isabelle , Novak Petr , Mudher Amritpal , Zilka Norbert
Published: April 2024

The transcellular propagation of the aberrantly modified protein tau along the functional brain network is a key hallmark of Alzheimer's disease and related tauopathies. Inoculation-based tau propagation models can recapitulate the stereotypical spread of tau and reproduce various types of tau inclusions linked to specific tauopathy, albeit with varying degrees of fidelity. With this systematic review, we underscore the significance of judicious selection and meticulous functional, biochemical, and biophysical characterization of various tau inocula. Furthermore, we highlight the necessity of choosing suitable animal models and inoculation sites, along with the critical need for validation of fibrillary pathology using confirmatory staining, to accurately recapitulate disease-specific inclusions. As a practical guide, we put forth a framework for establishing a benchmark of inoculation-based tau propagation models that holds promise for use in preclinical testing of disease-modifying drugs.
Experimental study on weathering mechanism of ancient bricks in Jiayuguan Wei-Jin tombs, Gansu, China
Authors: An Lihong , Qiao Zhen , Wang Jie , Wang Fengrui
Published: April 2024

This study focuses on the ancient bricks of Wei-Jin tombs in Jiayuguan, Gansu, China, analyzing the deterioration of the bricks under the long-term influence of natural environments and human activities. Currently, the ancient bricks exhibit various degradation diseases such as cracks, exfoliation, fracture, weathering, and microbial erosion, severely affecting the integrity of the cultural relics. Through on-site investigation and characterization testing, the physical and mechanical properties, compositional elements, pore size distribution, and thermal characteristics of the ancient bricks were analyzed. Indoor simulation experiments were conducted to study the impact of different types of environmental erosion cycles (such as H2O, HCl, NaOH, Na2SO4) on the performance and structure of the ancient bricks, the patterns and causes of deterioration were also studied. The results indicate that the cyclic effects gradually transform the porosity of the ancient bricks into lateral microcracks, which continue to expand, leading to varying degrees of degradation of performance. The extent of the impact of these cycles on the properties of ancient bricks is in descending order: Na2SO4, HCl, NaOH, H2O. H2O, NaOH, HCl, Na2SO4.
Who are the “police” in “police violence”? Fatal violence by U.S. law enforcement agencies across levels of government
Authors: Jahn Jaquelyn L. , Schwartz Gabriel L.
Published: April 2024

Background

Police violence is increasingly recognized as an urgent public health problem. Basic questions about police violence, however, remain unanswered, including which types of law enforcement agency are responsible for fatal police violence deaths.

Methods

We estimated the proportion of police violence deaths in the U.S. (2013–2022) that were attributable to local, county, state, federal, or tribal police agencies, using mapping police violence data. We examined proportions overall, by decedent race/ethnicity, and by state.

Results

Nationally, 60% of decedents were killed by municipal, 29% by county, 8% by state, and 3% by federal, police, with < 1% killed by tribal or other officers. These proportions varied by race/ethnicity, with 56% of Native American decedents killed by municipal police compared to 70–75% among other racially minoritized people. While municipal police were responsible for most deaths in most states, in the Southeast, county police predominated. In some Northeastern states (and Alaska), state police were responsible for > 40% of deaths.

Conclusions

We identify wide geographic & racial/ethnic variation in the agencies responsible for fatal police violence. Findings suggest that the budgetary and infrastructural shifts required to prevent fatal police violence need to occur at multiple levels of government.
Cx43 hemichannels and panx1 channels contribute to ethanol-induced astrocyte dysfunction and damage
Authors: Gómez Gonzalo I. , Alvear Tanhia F. , Roa Daniela A. , Farias-Pasten Arantza , Vergara Sergio A. , Mellado Luis A. , Martinez-Araya Claudio J. , Prieto-Villalobos Juan , García-Rodríguez Claudia , Sánchez Natalia , Sáez Juan C. , Ortíz Fernando C. , Orellana Juan A.
Published: April 2024

Background

Alcohol, a widely abused drug, significantly diminishes life quality, causing chronic diseases and psychiatric issues, with severe health, societal, and economic repercussions. Previously, we demonstrated that non-voluntary alcohol consumption increases the opening of Cx43 hemichannels and Panx1 channels in astrocytes from adolescent rats. However, whether ethanol directly affects astroglial hemichannels and, if so, how this impacts the function and survival of astrocytes remains to be elucidated.

Results

Clinically relevant concentrations of ethanol boost the opening of Cx43 hemichannels and Panx1 channels in mouse cortical astrocytes, resulting in the release of ATP and glutamate. The activation of these large-pore channels is dependent on Toll-like receptor 4, P2X7 receptors, IL-1β and TNF-α signaling, p38 mitogen-activated protein kinase, and inducible nitric oxide (NO) synthase. Notably, the ethanol-induced opening of Cx43 hemichannels and Panx1 channels leads to alterations in cytokine secretion, NO production, gliotransmitter release, and astrocyte reactivity, ultimately impacting survival.

Conclusion

Our study reveals a new mechanism by which ethanol impairs astrocyte function, involving the sequential stimulation of inflammatory pathways that further increase the opening of Cx43 hemichannels and Panx1 channels. We hypothesize that targeting astroglial hemichannels could be a promising pharmacological approach to preserve astrocyte function and synaptic plasticity during the progression of various alcohol use disorders.
Evaluation of Orexin-A Salivary Levels and its Correlation with Attention After Non-invasive Brain Stimulation in Female Volleyball Players
Authors: Moscatelli Fiorenzo , Monda Antonietta , Messina Antonietta , Monda Marcellino , Monda Vincenzo , Villano Ines , De Maria Antonella , Nicola Mancini , Marsala Gabriella , de Stefano Maria Ida , Limone Pierpaolo , Messina Giovanni , Polito Rita
Published: April 2024

Background

The capacity to change attention from one area to another depending on the many environmental circumstances present is a crucial aspect of selective attention and is strictly correlated to reaction time. The cholinergic system of the basal forebrain is crucial for attentive abilities. Several inputs, particularly orexin neurons, whose cell bodies are found in the postero-lateral hypothalamus, can activate the cholinergic system. The aim of this study was to investigate if high frequencies rTMS at dorsolateral prefrontal cortex (DLPFC) in highly trained volleyball players can change Orexin-A levels, attention and reaction time. This study was a double-blinded (participant and evaluator) matched-pair experimental design. Twenty right-handed female volleyball players were recruited for the study (age 24.6 ± 2.7 years; height 177.0 ± 5.5 cm; body mass 67.5 ± 6.5 kg; BMI 21.5 ± 1.2).

Results

The main finding of this study was that 10 Hz rTMS to the DLPFC seems to increase Orexin-A salivary levels and the percentage of correct answers, while decreasing RT. After rTMS, the athletes show an increase in the percentage of correct answers immediately after the end of stimulation, and also after 15 and 30 min. Moreover, the athletes show decreases in reaction time after the end of stimulation and after 15 and 30 min to the end of stimulation, while no differences were found at the end of stimulation. Finally, the athletes show significant increases in Orexin-A salivary levels after stimulation with a peak after 30’ of the end.

Conclusion

The results of our study seem to indicate that there is a relationship between salivary Orexin-A levels and RT. These results could provide useful tools for modulating sports training; in fact, if confirmed, they could lead coaches to offer their athletes rTMS sessions appropriately integrated with training. In fact, alternating attention is a mental flexibility that enables people to change their point of focus and switch between tasks requiring various levels of cognition.
Long-term cardiac effects of modern treatment for Hodgkin’s lymphoma
Authors: Bjerring Anders W , Smeland Knut HB , Stokke Thomas , Haugaa Kristina H , Holte Espen , Rösner Assami , Kiserud Cecilie E , Edvardsen Thor , Sarvari Sebastian Imre
Published: April 2024

Background

Hodgkin’s lymphoma (HL) is a hematological malignancy that affects both children and young adults. Traditional treatment is associated with a life-time prevalence of cardiac disease exceeding 50%. In the late 1990s protocols were modified to reduce cancer therapy-related adverse cardiac effects. This study aimed to assess the long-term impact of advances in treatment protocols on the cardiac health of HL survivors (HLS).

Methods

HLS (n = 246) treated between 1997 and 2007 with anthracycline-based chemotherapy in three centers in Norway were included. Of these, 132 (53%) had also received mediastinal radiotherapy. HLS were compared to controls (n = 58) recruited from the general population and matched for sex, age, smoking status, and heredity for coronary artery disease. All subjects underwent echocardiography, clinical assessment, and blood sampling.

Results

The HLS were 46 ± 9 years old and had been treated 17 ± 3 years before inclusion in the study. There was no significant difference between HLS and controls in ejection fraction (EF) (58%±5 vs. 59%±4, p = 0.08) or prevalence of heart failure. HLS treated with both anthracyclines and mediastinal radiotherapy (AC + MRT) had slightly worse left ventricular global longitudinal strain than controls (-19.3 ± 2.5% vs. -20.8 ± 2.0%, p < 0.001), but those treated with only anthracyclines did not. HLS treated with AC + MRT had a higher prevalence of valve disease than those treated only with anthracyclines (12% vs. 4%, p < 0.05).

Conclusions

HLS treated with anthracyclines after the late 1990s have similar cardiac function and morphology as age-matched controls, apart from higher rates of valvular disease in those who also underwent mediastinal radiotherapy.
Impact assessment of integrated-pathy on cancer-related fatigue in cancer patients: an observational study
Authors: Balkrishna Acharya , Katiyar Prashant , Ghosh Sourav , Singh Sumit Kumar , Arya Vedpriya
Published: April 2024

Background

Integrated-pathy aims to integrate modern medicine with traditional systems via applying the holistic approach of Ayurveda, Yoga, and natural medicine. This is important for addressing the challenges surrounding the delivery of long-term palliative care for chronic ailments including cancer. The prime intent of this study was to substantiate the underlying hypothesis behind the differential and integrative approach having a positive impact on Quality of Life of cancer patients.

Study design

Cross-sectional Observational study.

Methods

A standardized questionnaire was developed and used, after obtaining written informed consent from patients to assess the impact of Integrated-pathy on patients (n = 103) diagnosed with cancer receiving care at Patanjali Yoggram. The research was carried out over 8 months. All participants received a uniform treatment protocol as prescribed by Patanjali. For the sample size determination and validation, α and 1-β was calculated and for the significance of the pre- and post-treatment QoL ratings, Shapiro wilk test and other descriptive statistics techniques were explored.

Results

A total of 103 patients seeking cancer special-healthcare were interviewed, out of which 39 (37.86%) remained finally based on the inclusion/exclusion criteria with age (25–65 years), types of cancers (Carcinoma and Sarcoma), chemotherapy/radiotherapy received or not, before opting Integrated-pathy. Follow-ups revealed a significant increase in the QoL (17.91%) after receiving the integrated therapy over a course of at least 1 month. Further, a significant reduction in cancer-related pain followed by an increase in QoL index was reported in the patients. Shapiro–wilk test revealed significant pairing (p < 0.001) with validation of the model using test.

Conclusions

To bolster evidence-based backing for Integrated-pathy, there is a need for clearly delineated clinical indicators that are measurable and trackable over time. Clinical investigators are encouraged to incorporate Integrated-pathy into their proposed interventions and conduct analogous studies to yield sustained advantages in the long run.
Analyzing the impact of an MDG-Fund program on childhood malnutrition in Timor-Leste
Authors: Van der Spek L. , Sonneveld B. G. J. S.
Published: April 2024

Background

Timor-Leste’s food insecurity, propelled by political conflicts, a fragile economy and biophysical limitations that characterize mountainous Small Island Developing States (SIDS), is expressed in a high incidence (50%) of stunted children. Hence, the Millennium Development Goals Achievement Fund’s Joint Program’s (MDG-F JP) in 2009 was a timely intervention to reduce prevalence of underweight among under-fives. Since the impact of the program remains largely unclear, the current study investigates the contributions of the MDG-F JP on improving children’s nutritional status in Timor-Leste, in order to inform policymakers on how to make future programs more effective.

Methods

Using bivariate analyses and multiple linear regression models we analyzed Demographic and Health Survey (DHS) data from under-fives in 2009–2010 and 2016, combined with spatially explicit data from geographic information systems (GIS). The analyses generated trends and factors associated with undernutrition, which were used in a quasi-experimental setting to compare districts that received the MDG-F JP with similar districts that did not receive MDG-F JP interventions.

Results

A comprehensive set of factors dependent on seasons, locations, and individuals determine undernutrition in Timor-Leste. A positive impact of the MDG-F JP was found for the average severity of wasting, but not for stunting and underweight.

Conclusions

The findings reinforce the pressing need for integrated and cross-sectoral programs, aimed especially at agricultural workers, mothers, and children. The agricultural challenge is to sustainably select, produce and conserve higher-yield and nutrient-rich crops, and educational enhancement should be aligned with local practices and research.
Association of hirsutism and anthropometric profiles with sexual dysfunction and anxiety levels in infertile Indonesian women with polycystic ovarian syndrome
Authors: Rahayu Deniswari , Meutia Alfa Putri , Priyatini Tyas , Suratih Ni Made Desy , Maidarti Mila , Harzif Achmad Kemal , Muharam R. , Pratama Gita
Published: April 2024

Background

Hyperandrogenism is frequently found in polycystic ovary syndrome (PCOS) and contributes to physical manifestations like hirsutism and obesity, along with infertility. This condition can result in anxiety, depression, and body image disorders, potentially leading to sexual dysfunction. The objective of this investigation was to assess the correlation among hirsutism, anthropometric characteristics, sexual dysfunction, and anxiety levels among infertile Indonesian women diagnosed with PCOS.

Methods

From December 2021 to December 2022, a cross-sectional study was undertaken involving 71 infertile women diagnosed with PCOS at Yasmin Clinic, Dr. Cipto Mangunkusumo General Hospital in Jakarta, Indonesia. Hirsutism was assessed using the modified Ferriman-Gallwey (mFG) score; the anthropometric profile was assessed using BMI and waist-to-hip ratio. The assessment of sexual dysfunction was conducted using the Female Sexual Function Index (FSFI) questionnaire, while the evaluation of anxiety levels utilized the HAM-A questionnaires.

Results

In this study, it was discovered that 53.3% of subjects experienced sexual dysfunction. However, there was no statistically significant relationship between hirsutism, anthropometric profile, and sexual dysfunction score in infertile women with PCOS (p > 0.05). Analysis of the overall FSFI domain score revealed that lubrication and satisfaction were lower in obese patients (p = 0.02 and p = 0.03), but this did not contribute to an overall sexual dysfunction score. Also, we found that subjects who experienced sexual dysfunction had a higher anxiety score (p < 0.005), with correlation analysis showing that Ferriman-Gallwey (FG) scores have a significant positive correlation with anxiety.

Conclusion

There is no correlation between hirsutism, anthropometric profile, and sexual dysfunction in infertile Indonesian women diagnosed with PCOS. However, hirsutism could play a role in causing anxiety in Indonesian PCOS women. Additional investigation is required, as female sexual function is an intricate subject.
Predictive factors for failure of nonsurgical management of intussusception and its in-hospital recurrence in pediatric patients: a large retrospective single-center study
Authors: Chrapusta Maria Klimeczek , Preinl Maciej , Łubniewska Zofia , Procháska Filip , Gruba Maria , Górecki Wojciech
Published: April 2024

Background

This study explores the effectiveness of ultrasonography (USG)-guided saline enema reduction for ileocecal intussusception. It investigates factors, ascertainable through physical examination, ultrasound, and medical history, that impact the success of the procedure and the likelihood of recurrence.

Results

Conducted at a tertiary referral center, the study included 323 pediatric cases diagnosed with intussusception between 2017 and 2023. Patient data, symptoms, signs, and outcomes were collected. Hydrostatic saline enema, performed under USG guidance, served as the primary non-operative treatment. Logistic regression models assessed the impact of clinical factors on success and recurrence rates. Out of 323 patients examined for eligibility, 184 met inclusion criteria and were analyzed. Successful reduction with saline enema was achieved in 86.7%. In-hospital recurrence occurred in 17.1%, notably higher for intussusceptions extending into the rectum (p < 0.03). Pathologic lead point was identified in 33.3% of operated cases. The study revealed a correlation between the increasing number of symptoms (p < 0.001) and reduced success rates in enema reduction, with vomiting (p < 0.02), diarrhea (p < 0.05), and peritoneal fluid (p < 0.008) negatively affecting outcomes. Symptom duration of 1–9 h (p < 0.001) and 10–24 (p < 0.01) correlated with higher success rates, but prolonged symptom duration of > 24 (p = 0.4) and 48–72 (p = 0.2) hours did not decrease chances for successful reduction.

Conclusions

Prolonged symptom duration of over 24 and 48–72 h should not be a definitive contraindication for non-operative treatment. Cumulation of symptoms typical for intussusception might reduce the chances of success. These findings contribute valuable insights into optimizing non-operative strategies for managing pediatric intussusception.
Leverage of applying diffusion tensor imaging (DTI) indices in assessment of cervical spondylotic myelopathy
Authors: Ragaee Sara Mahmoud , Gawad Enas A. Abdel , Gamal Sara , Nageeb Mohab Mohamed , Ibrahim Ahmed Sayed
Published: April 2024

Background

Cervical spondylotic myelopathy (CSM) is the most prevalent form of dysfunction in the cervical cord. For best results, CSM must be identified and treated quickly, before spinal cord injury develops. We aimed at determining the diagnostic value of quantitative and qualitative diffusion tensor imaging (DTI) indices in the assessment of CSM. Thirty patients were included in this prospective study with clinically suspected CSM of both sexes. This study aimed at determining the diagnostic value of quantitative and qualitative DTI indices in early assessment of CSM and subsequently early and proper management decision rendering better clinical outcome.

Results

This prospective study included 30 patients: with clinically suspected CSM with a mean age of 51.88 ± 10.28 years. Patients with CSM were graded to 3 grades, mild (No. = 17), moderate (No. = 13) and severe (No. = 0) according to the modified Japanese orthopedic association (mJOA) grading system. Correlation test was performed between mJOA grades of severity with fractional anisotropy (FA), apparent diffusion coefficient (ADC) and T2 cord signal. We found a negative correlation between ADC and FA with Spearman’s rho value of − 0.612 and “P value 0.000” (P value < 0.05), a positive correlation between FA with mJOA clinical score with Spearman’s rho value of − 0.504 & “P value 0.036” (P value < 0.05) and a negative correlation between ADC and mJOA clinical score with Spearman’s rho value of 0.385 and P value 0.005 (P value < 0.05), and no significant correlation was found between mJOA clinical score and T2 hyperintense signal with Spearman’s rho value of − 0.304 and “P value 0.102” (P value < 0.05). Qualitative maps grading by 3D tractography images were done, and 18 patients in the study (60%) showed homogenous intact fiber tracts (grade I), 9 patients (30%) showed reduction or alteration of anisotropy or mixed colors intensity (grade II), and 3 patients (10%) showed fiber tract disruption or displaced cord (grade III). Three DTI parameters (other than FA and ADC) were measured, and two of them show significant difference between their measures in the stenotic and non-stenotic portions of the spinal cord—RA (P value = 0.00) and RD (P value = 0.00).

Conclusions

We concluded that DTI is a crucial tool for early diagnosis and grading of CSM (cervical spondylosis myelopathy)—quantitatively and qualitatively—hence, it should be routinely integrated with conventional cervical spine MRI in case of clinically or radiologically suspected cervical cord compression, as the FA parameter together with the clinical assessment formulates the management plan decision for the CSM whether surgical or non-surgical and depicts the need for early surgical decision rendering better clinical outcome compared to that based on T2 hyperintense cord signal.
Amelanotic melanoma detected by 18F-FDG PET-CT
Authors: Chen Ningning , Liu Xin , Pu Yongzhu , Feng Chengtao , Yang Fake , Yang Conghui , Chen Long
Published: April 2024

Background

Amelanotic/hypomelanotic melanoma is an extremely rare cancer and accounts for less than 1/10,000 in the population. For losing and hypomelanotic pigment, amelanotic melanoma can lead to misdiagnosis with benign skin lesions. Therefore, early recognition and diagnosis is important to avoid a delay in treatment.

Case presentation

A 73-year-old man presented for a gradually enlarged nodule on the surface skin of the left crus, with no color change, ulceration, or bleeding. Malignant lesion was suspected based on computed tomography (CT) and magnetic resonance imaging (MRI), and biopsy was scheduled. Immunohistochemical (IHC) revealed amelanotic melanoma followed by biopsy.18Florine-fluoro-2-deoxy-2-d-glucose (18F-FDG) positron emission tomography-computed tomography (PET-CT) was employed to explore whether there are metastases or not. 18F-FDG PET-CT showed increased FDG accumulation with standardized uptake value max (SUVmax) of 5.6 of the lesion, and no other lesions were detected. The patient refused to be hospitalized and died 12 months later.

Conclusion

This case highlights the need of considering melanoma even if there is no color change. Increased FDG uptake from PET-CT is prone to be consistent with malignant disease as well as whole body scan is crucial in determining the accurate TNM stage. Moreover, prompt treatment according to guidelines is necessary even if the disease is at its early stage.
Lung infections in HIV-infected children: imaging pattern recognition and its correlation with CD4 counts
Authors: Goel Vishal , Narula Mahender K. , Bano Shahina , Anand Rama , Chaudhary Vikas , Singh Varinder , Saxena Sonal
Published: April 2024

Context

Children with human immunodeficiency virus (HIV) infection frequently present with opportunistic infections of the lung that may be associated with high mortality rate. There is no study, to the best of our knowledge, correlating specific radiographic patterns of chest infections with CD4 levels of immunity in HIV-infected children of Indian subcontinent (where prevalence of respiratory tuberculosis is very high).

Aims

To study the radiological patterns of chest infections in HIV-infected children, and to correlate these radiological findings with CD4 cell count and final diagnosis.

Methods

Forty-five HIV-infected children (1–18 years of age) with suspected chest infections were included in the study. The baseline and the most recent CD4 counts were recorded for each patient. Chest X-ray (CXR) was obtained in all the patients, and multi-detector computed tomography (MDCT) chest was done in 27 patients having clinical suspicion of infection with normal or equivocal findings on CXR. Chest radiographs and MDCT chest were analyzed for different radiological patterns of chest infections. Imaging findings were correlated with CD4 count range for disease spectrum. The final etiopathological diagnosis was achieved in combination with clinico-radiological findings, laboratory data, cytohistopathology and follow-up imaging.

Results

Out of 45 children confirmed to be HIV-infected, 27 (60%) had bacterial infection, 14 (31.11%) had tuberculosis, and four (8.89%) had fungal infection.

Consolidation on CXR/CT strongly suggested bacterial etiology (P < 0.05). Mediastinal/hilar lymphadenopathy (with or without necrosis) strongly suggested tubercular etiology (P value < 0.05). Diffuse GGO/haziness on CXR/CT strongly suggested fungal etiology (P value < 0.05).

On correlation with CD4 count (cells/mm3), the bacterial infections occurred at early stages of HIV infection when immune status was relatively preserved, and most of the patients with tubercular infection had moderate immunosuppression. On the other hand, all patients of fungal infection showed severe immunosuppression.

Conclusion

A wide spectrum of pulmonary disease encountered in HIV-infected children warrants an integrated approach of image interpretation. Familiarity with the imaging patterns, combined with relevant clinical/laboratory details, may greatly help to improve the diagnostic confidence and to reach to a more meaningful differential diagnosis.
The value of adding T2 mapping sequence to the routine MRI protocol in the evaluation of cartilage lesions of the ankle joint
Authors: Mostafa Alaa , Mohamed Ahmed Mostafa , Osman Ahmed Mohamed , Hossam El Din Nourhan Mohammed
Published: April 2024

Background

Ankle joint cartilage injury is frequently associated with degenerative changes, even in the absence of symptoms. Earlier treatment of cartilage damage with joint preservation is clearly more successful. The main limitation of morphologic cartilage magnetic resonance imaging sequences is that they are not very sensitivity in the detection of early cartilage degeneration. Recent advances in biochemical magnetic resonance imaging have yielded sequences that are sensitive to molecular changes in the composition of cartilage matrix. This includes water- and collagen-sensitive T2\T2* mapping. The aim of this study was to determine the extent of improvement of the diagnostic performance of routine magnetic resonance imaging protocol in the evaluation of ankle joint articular cartilage lesions following the addition of a T2 mapping sequence.

Results

A total of 45 cases, 30 patients (12 male and 18 female) and 15 controls (10 male and 5 female) who underwent routine ankle magnetic resonance imaging with additional T2 mapping sequence, were included in the study. Out of 30 patients, four patients were misdiagnosed as being normal, while having changes of cartilage composition of early degenerative changes, discovered by T2 mapping sequence. The patients group as well as the-control groups had significantly higher T2-values in the superficial cartilage layer (P < 0.001) compared to the deep layer. When comparing between the medial and the lateral compartments at patients group, the T2-relaxation times were more pronounced in the medial talar cartilage compartment compared to the lateral talar cartilage compartment.

Conclusions

Magnetic resonance imaging can observe not only the destruction of the structural integrity but also the change of the components in articular cartilage. In this study, the addition of a T2 mapping of the ankle cartilage sequence to a routine MR ankle protocol improved sensitivity and accuracy in the detection of early cartilage lesions within the ankle joint.
Affordances of Fantasy
Authors: Attebery Brian
Published: April 2024

Each of the functions of fantasy described by J. R. R. Tolkien in his essay “On Fairy-Stories” can be reframed through affordance theory into a kind of re-visioning. Such re-visioning is comparable to the formalist notion of defamiliarization or the science fiction technique that Darko Suvin called “cognitive estrangement.” Whereas science fiction projects alternative futures, fantasy's affordances allow writers to generate alternative worldviews grounded in real or invented mythic pasts. The initial move away from claiming to imitate reality allows fantasy writers to project inner experience onto an outer storyworld (there is no pathetic fallacy in fantasy), to depict multiple contradictory selves (housed within a single body or spread out over several characters), and to invite readers to consider alternatives to commonsense assumptions and seemingly inevitable social orders.
KATANIN-mediated microtubule severing is required for MTOC organisation and function in Marchantia polymorpha
Authors: Attrill Sarah T. , Dolan Liam
Published: April 2024

Microtubule organising centres (MTOCs) are sites of localised microtubule nucleation in eukaryotic cells. Regulation of microtubule dynamics often involves KATANIN (KTN): a microtubule severing enzyme that cuts microtubules to generate new negative ends, leading to catastrophic depolymerisation. In Arabidopsis thaliana, KTN is required for the organisation of microtubules in the cell cortex, preprophase band, mitotic spindle and phragmoplast. However, as angiosperms lack MTOCs, the role of KTN in MTOC formation has yet to be studied in plants. Two unique MTOCs – the polar organisers – form on opposing sides of the preprophase nucleus in liverworts. Here, we show that KTN-mediated microtubule depolymerisation regulates the number and organisation of polar organisers formed in Marchantia polymorpha. Mpktn mutants that lacked KTN function had supernumerary disorganised polar organisers compared with wild type. This was in addition to defects in the microtubule organisation in the cell cortex, preprophase band, mitotic spindle and phragmoplast. These data are consistent with the hypothesis that KTN-mediated microtubule dynamics are required for the de novo formation of MTOCs, a previously unreported function in plants.
Identification of 30 transition fibre proteins in Trypanosoma brucei reveals a complex and dynamic structure
Authors: Ahmed Manu , Wheeler Richard , Týč Jiří , Shafiq Shahaan , Sunter Jack , Vaughan Sue
Published: April 2024

Transition fibres and distal appendages surround the distal end of mature basal bodies and are essential for ciliogenesis, but only a few of the proteins involved have been identified and functionally characterised. Here, through genome-wide analysis, we have identified 30 transition fibre proteins (TFPs) and mapped their arrangement in the flagellated eukaryote Trypanosoma brucei. We discovered that TFPs are recruited to the mature basal body before and after basal body duplication, with differential expression of five TFPs observed at the assembling new flagellum compared to the existing fixed-length old flagellum. RNAi-mediated depletion of 17 TFPs revealed six TFPs that are necessary for ciliogenesis and a further three TFPs that are necessary for normal flagellum length. We identified nine TFPs that had a detectable orthologue in at least one basal body-forming eukaryotic organism outside of the kinetoplastid parasites. Our work has tripled the number of known transition fibre components, demonstrating that transition fibres are complex and dynamic in their composition throughout the cell cycle, which relates to their essential roles in ciliogenesis and flagellum length regulation.
Discrimination of persons with mental illness: testing the principles for the protection of persons with mental illness and the improvement of mental health care in Indonesia
Authors: Simanjuntak Nelson , Tampubolon Manotar , Farinella Favio
Published: April 2024

Background Discriminatory acts against individual freedom rights in the context of human rights and dignity in Indonesia have been in the international spotlight due to human rights violations for years. Although the condition of individuals with mental disorders in Indonesia is quite worrying when viewed from the context of human rights; however, some basic mental health services are not available in most parts of the country. Methods This qualitative research uses secondary data such as health literature, social scientific, and national legal studies. The thematic analysis in this study concentrates on answering different research questions. However, this study encountered limited scope on two grounds; the first focuses on whether the National Mental Health Act (MHA) meets the basics set by the principles of CRPD. The second was the impact of other different rights on people with mental disorders. Results The results of this study on the number of cases of shackles and the differences between International Mental Health standards and the Indonesian Mental Health Act are also presented. A total of 23 studies have been used to determine the result from the analysis. It has been observed that adequate knowledge and awareness of people about mental retardation and health issues guide to the poor attitude as well as treatment of them. As per the report of Human Rights Watch in 2019, approximately 57,000 individuals with mental illness have been humiliated once in their overall lifetime in Indonesia. Conclusions The tradition of shackles (pasung) has resulted in ongoing suffering due to ineffective actions that violate human freedom and are contrary to human values. The Indonesian government should provide proper facilities for individuals with mental disorders to protect and cure them the people who have mental disorders and structure its laws more strongly.
The potential of Sonneratia caseolaris mangrove leaves extract as a bioactive food ingredient using various water extract
Authors: Kartikaningsih Hartati , Fitriana Nur , Anggraeni Ike Listya , Semedi Bambang , Pertiwi Koentjoro Maharani
Published: April 2024

Background Sonneratia caseolaris, known as the red pidada, has been widely utilized by the Indonesian. S. caseolaris leaves contain various active compounds, contributing to their popularity in the treatment of various diseases. Mangrove leaves are also known to exhibit very high antioxidant activity. This study aims to assess the antioxidant activity of S . caseolaris leaves extracted using different solvents. The resulting extract was evaluated for antioxidant activity by the 2,2-diphenyl-1-picrylhydrazyl radical scavenging activity (DPPH) techniques. Methods Analysis of total flavonoids, total phenols, identification of active compounds with Liquid Chromatography High Resolution Mass Spectrometry (LC-HRMS), and bioinformatics were also carried out to obtain temporary conclusions about the antioxidant activity of S. caseolaris leaf extract. Results The results indicated that S. caseolaris leaves extracted with methanol and distilled water exhibited the highest antioxidant activity compared to other extracts. The analysis of total flavonoids and total phenols yielded results consistent with the antioxidant activity tests. LC-HRMS results identified three compounds in all S. caseolaris leaf extracts with antioxidant activity, namely Tempo, Choline, and Betaine. Tempo demonstrated a higher antioxidant activity than Choline and Betaine, as indicated by the binding affinity values in the bioinformatics analysis. Conclusions It is evident that S. caseolaris leaf extract has the potential to serve as an effective an antioxidant agent. Further research is needed to elucidate confirm the effectiveness of S. caseolaris leaves as an antioxidant substance, in order to utilize them as active components in food and enhance antioxidant consumption among consumers.
Effect of diaphragmatic stretch technique on thoracic excursion and pulmonary function in COPD patients: Study protocol for randomized controlled trial.
Authors: K. Chilhate Priyanka , Lalwani (Adwani) Lajwanti , Vardhan Vishnu
Published: April 2024

Limited airflow is a defining feature of COPD, a respiratory disease that frequently results in reduced thoracic movement and compromised lung function. The diaphragm, which is the main breathing muscle, is essential for healthy lung expansion and ventilation. The diaphragm muscle’s flexibility and mobility are intended to be enhanced via diaphragmatic stretching. This method can enhance respiratory health and assist in returning the diaphragm to its original state. Patients with COPD may benefit from improved lung expansion and ventilation because of this. The usefulness of integrating the diaphragmatic stretch approach with traditional chest physical therapy is not well-established. Thus, research is needed to ascertain how the diaphragmatic stretch technique affects lung function and thoracic excursion in COPD patients. This study aims to ascertain how the diaphragmatic stretch technique affects thoracic excursion and pulmonary function (FEV1, FVC, FEV1/FVC, FEF25%-75%, PEFR) in individuals with COPD. There will be 58 COPD patients enrolled in total for this trial; 29 will receive traditional chest physiotherapy along with the diaphragmatic stretch technique, and 29 will receive traditional chest physiotherapy exclusively. Two weeks will pass throughout the intervention. Prior to the intervention, pre-outcome measures will be evaluated, and two weeks later, post-outcome measures will be evaluated once more. The anticipated outcome of this study is that the diaphragmatic stretch technique can enhance thoracic excursion and improve pulmonary function just as well as traditional chest physiotherapy when used in conjunction with it.
Empowering Innovation in Banking Insurance: Expert System for Information Management
Authors: Rojas Serrano José , Mora-Aguilar Raúl , Pacheco-Pumaleque Alex
Published: April 2024

Background Nowadays, financial institutions face and solve challenges to optimise Information Management (IM), so the use of new technologies such as Expert Systems (ES) is indispensable. Therefore, the objective of this research is to implement an ES to improve IM in insurance companies. Method In terms of approach, the agile methodology SCRUM was chosen, which consists of five phases: initiation, planning and estimation, implementation, review and retrospective, launch, and thus decision making and optimisation of the IM process. In addition, the following technologies were chosen: ASP.NET as programming language, HTML as markup language, SQL Server as database management and CSS for design and visual styling. Results The results also showed a significant increase of 35% in user service, accompanied by a significant improvement of 44% in report delivery. Finally, a significant improvement of 24% was observed following the implementation of the expert system. This streamlines processes, reduces waiting times, improves the user experience in real time and optimises the management of large volumes of data in the insurance company. Conclusions The system demonstrated that this tool improves decision making, reduces errors in the issuing area and provides a user-friendly interface for information management.
BUSINESS REPUTATION OF A SOVEREIGN TERRITORY UNDER THE ADOPTION OF OwN MANAGEMENT STANDARDS
Authors: Smetanina T.
Published: April 2024

The article reflects the interconnection of the idea of the business reputation of a sovereign territory on the part of interested parties, based on their own management standards. The question of the interest of individuals in the process of establishing the sovereignty of the territory in which they live is being studied. The role of corporate social responsibility in shaping the business reputation of organizations is determined. The place of individuals in the process of self-determination of the state is assessed. The concept of brand citizenship is considered. The basis of the independence of the object of study within the framework of its self-sufficiency and individuality is seen. The objects of study are the social component of social relations associated with the elements of the scalar chain of control, namely organizations, industries, sovereign territories and individuals. A sociological study of the phenomenon that determines the relationship of business reputation with management standards and their belonging to the territory in which they operate is being carried out. The article proposes to use the unconscious influence of individuals on the process of establishing the business reputation of a sovereign territory through a tripartite interaction between government, business and society.
Welche Organisationsformen produzieren Wissenschaft?
Authors: Dusdal Jennifer
Published: April 2024

Wie haben die Institutionen des deutschen Hochschul- und Wissenschaftssystems die Entwicklung wissenschaftlicher Produktivität beeinflusst? Jennifer Dusdal zeigt, welche Organisationsformen Wissenschaft produzieren und wie sich ihre Ziele, Aufgaben und Arten der Forschung unterscheiden. Sie hat Zeitschriftenartikel aus den Natur- und Technikwissenschaften sowie der Medizin untersucht, die zwischen 1900 und 2010 publiziert wurden. So wird deutlich, dass die Universität die wichtigste Wissenschaft produzierende Organisationsform geblieben ist und die wissenschaftliche Produktivität aufgrund gestiegener Forschungskooperationen exponenziell gewachsen ist. https://creativecommons.org/licenses/by-nc-nd/4.0/
Passion und Kalkül
Authors: Gautier Michael
Published: April 2024

Galeristinnen und Galeristen sind zentrale Akteure des Kunstfeldes. Sie entdecken neue Kunst und machen sie bekannt. Doch wer eröffnet und betreibt eine erfolg- und einflussreiche Galerie für Gegenwartskunst? Diese soziologische Studie lotet anhand europäischer und amerikanischer Beispiele die Motive sowie die Denk- und Handlungsweisen von Personen aus, denen das riskante Unterfangen gelingt. Sie erschließt, wie der Beruf im Spannungsfeld von Kunstund Geschäftssinn, Leidenschaft und kommerzieller Logik gedeutet und praktiziert wird.
Semiotik, Physik, Organik
Authors: Richter Linda
Published: April 2024

Die Art und Weise, wie die Menschen über das alltägliche und zugleich so komplexe Wetter nachdenken, hat eine überraschende Geschichte. Bevor die Meteorologie um 1850 eine Physik der Atmosphäre wurde, gab es verschiedene Formen des Wetterwissens: eine, die nach Naturgesetzen forschte, aber auch eine, die Wetterzeichen sammelte und eine, die das Wetter als Teil eines natürlichen Organismus untersuchte. Diesen verschiedenen historischen Wissensformen und ihren Akteuren geht die vorliegende Studie auf den Grund. Untersucht wird, wie sich die moderne Meteorologie aus ihnen entwickelte – und auch, welches Wissen dabei verlorenging. https://creativecommons.org/licenses/by-nc-nd/4.0/deed.de
Prekäre Arbeit, prekäre Liebe
Authors: Wimbauer Christine , Motakef Mona
Published: April 2024

Erwerbsarbeit und Paarbeziehungen sind wichtige Quellen für Anerkennung. Doch was geschieht, wenn Arbeit prekär wird? Wie wirken sich unsichere Arbeitsverhältnisse und Anerkennungsdefizite auf die Liebe aus, auf Beziehungen und auf die Lebenszusammenhänge der Menschen überhaupt? Welche Ungleichheiten zwischen den Geschlechtern werden sichtbar? Das Buch zeichnet anhand von Interviews eindrücklich nach, welch destruktives Potenzial prekäre Erwerbsarbeit entfalten kann und was das für die Einzelnen, für Paare und für die Gesellschaft bedeutet. Außerdem entwickeln die Autorinnen Vorschläge, wie sich auf prekäre Beschäftigung, Geschlechterungleichheiten sowie auf Anerkennungsbedürftigkeit und Verletzbarkeit reagieren lässt. Dieses Werk ist lizensiert unter der Creative-Commons-Lizenz 4.0, CC-BY-SA: https://creativecommons.org/licenses/by-sa/4.0/deed.de
Arktisches Wissen
Authors: Pfäffli Lea
Published: April 2024

Als sich der Wettlauf um Nordwestpassage und Nordpol im frühen 20. Jahrhundert verschärfte, suchte die dänische Administration Grönlands nach Verbündeten. Als Zulieferer kolonialen Wissens rekrutierte sie Schweizer Naturforscher, die sich ihrerseits als nationale Polarhelden vermarkteten. An welche Auflagen waren die Forschungsreisenden aus der Schweiz in der Arktis gebunden? Wie kontrollierte die dänische Handelsgesellschaft den Kontakt der Außenseiter zur lokalen Bevölkerung, den Inuit? Wer finanzierte die Expeditionen? Lea Pfäffli erzählt eine transimperiale Geschichte arktischen Wissens und leuchtet dabei Kolonialreich und Nation neu aus. https://creativecommons.org/licenses/by/4.0/