bluuebunny/crossref_metadata_2025 huggingface dataset:
The dynamics of food for special medical purposes (FSMPs) utilization in cancer care: from doctor recommendations to online pharmacy procurement
Authors: Chereches Marius Călin , Popa Cristian Olimpiu , Finta Hajnal
Published: July 2024

This cross-sectional study conducted in Romania examines the increasing role of online pharmacies in providing Food for Special Medical Purposes (FSMP) to cancer patients. Key findings indicate patient satisfaction with ease of access, significant challenges related to costs, and the critical role of healthcare professionals in guiding FSMP selection. Introduction. As cancer treatments advance, the demand for supportive nutritional care becomes increasingly critical, with FSMPs playing a vital role in patient recovery and quality of life. Methods. Employing a cross-sectional study design, we surveyed cancer patients from Romania to assess their experiences purchasing FSMPs through traditional and online pharmacies. We analyzed the factors influencing their choices, the perceived benefits and challenges of online access, and the role of healthcare professional guidance in their decision-making process. Results. The study reveals that while patients appreciate the ease of access and the broad spectrum of available FSMPs online, they grapple with the financial burden and the need for reliable information to make informed decisions. Through a cross-sectional analysis, we found that the expertise and recommendations of healthcare professionals remain integral to the FSMP selection process, suggesting that digital solutions should enhance, not replace, traditional healthcare interactions. Moreover, our findings highlight a crucial gap in the taste and variety of FSMPs, suggesting that patient adherence could be improved through product innovation. The study found a significant association between the type of medical unit where patients followed their treatment (state-owned clinic) and whether they received recommendations from a specialist oncologist for using FSMPs. Nutritionists’ recommendations were also significantly associated with a higher likelihood of purchasing FSMPs online. Discussions. The study reveals that despite the benefits of digital access, a crucial need exists for regulatory measures and professional oversight to ensure the safe and informed use of FSMPs. The trust placed in healthcare professionals’ recommendations continues to be instrumental in navigating the digital marketplace. Conclusion. This work paves the way for future strategies to integrate online solutions with established healthcare practices to optimize cancer care in the digital age.
The SAR analysis of dietary polyphenols and their antagonistic effects on bortezomib at physiological concentrations
Authors: Van Tran Tran Thi , Chang Hsun-Shuo , Wu Ho-Cheng , Lu Chung-Kuang , Huang Hui-Chi , Korinek Michal , Hsiao Hui-Hua , Yen Chia-Hung
Published: July 2024

Background: Bortezomib (BTZ), a primary treatment for MM, but its effectiveness can be reduced by interactions with vicinal diol moieties (VDMs) in polyphenols. Despite this, it’s debated whether BTZ therapy necessitates avoiding polyphenol-rich products, given the low bioavailability of polyphenols. Additionally, it remains unclear whether the structure of polyphenols contributes to their BTZ antagonism. Therefore, our study aims to unravel the structure-activity relationship of dietary polyphenols and their BTZ antagonism at daily diet-achievable physiological concentrations.

Methods: We assessed the antagonistic effects of 25 polyphenols against BTZ using cell viability assays in RPMI 8226 cells. ChemGPS-NP helped analyze the structural similarity. Additionally, long-term cytotoxicity assays evaluated these effects at physiologically relevant concentrations.

Results: By cell viability assays, we found a positive correlation between the number of VDMs in gallotannins and their BTZ antagonism. Moreover, the origin and configuration of VDMs, rather than the total VDM concentration, play a pivotal role in the combined antagonistic effects against BTZ in gallotannins. Additionally, ChemGPS-NP analysis indicated that the aromaticity and C-3 hydroxyl group in flavonoids’ C-rings enhance their BTZ antagonism. Finally, long-term cytotoxicity assays reveal that gallic acid (GA), epigallocatechin (EGC), and epigallocatechin gallate (EGCG), at their physiological concentrations—attainable through tea consumption—significantly and synergistically antagonize BTZ.

Conclusion: Due to the potential for these polyphenols to reduce the effectiveness of BTZ, it is advisable for MM patients undergoing BTZ treatment to reduce their consumption of foods high in VDM-containing polyphenols.
Implications of endoplasmic reticulum stress and autophagy in aging and cardiovascular diseases
Authors: Ma Chenguang , Liu Yang , Fu Zhiling
Published: July 2024

The average lifespan of humans has been increasing, resulting in a rapidly rising percentage of older individuals and high morbidity of aging-associated diseases, especially cardiovascular diseases (CVDs). Diverse intracellular and extracellular factors that interrupt homeostatic functions in the endoplasmic reticulum (ER) induce ER stress. Cells employ a dynamic signaling pathway of unfolded protein response (UPR) to buffer ER stress. Recent studies have demonstrated that ER stress triggers various cellular processes associated with aging and many aging-associated diseases, including CVDs. Autophagy is a conserved process involving lysosomal degradation and recycling of cytoplasmic components, proteins, organelles, and pathogens that invade the cytoplasm. Autophagy is vital for combating the adverse influence of aging on the heart. The present report summarizes recent studies on the mechanism of ER stress and autophagy and their overlap in aging and on CVD pathogenesis in the context of aging. It also discusses possible therapeutic interventions targeting ER stress and autophagy that might delay aging and prevent or treat CVDs.
Bibliometric and visualized analysis of ultrasound combined with microbubble therapy technology from 2009 to 2023
Authors: Tu Bin , Li Yan , Wen Wen , Liu Jian
Published: July 2024

Background

In recent years, with the rapid advancement of fundamental ultrasonography research, the application of ultrasound in disease treatment has progressively increased. An increasing body of research indicates that microbubbles serve not only as contrast agents but also in conjunction with ultrasound, enhancing cavitation effects and facilitating targeted drug delivery, thereby augmenting therapeutic efficacy. The objective of this study is to explore the current status and prevailing research trends in this field from 2009 to 2023 through bibliometric analysis and to forecast future developmental trajectories.

Methods

We selected the Science Citation Index Expanded (SCI-Expanded) from the Web of Science Core Collection (WOSCC) as our primary data source. On 19 January 2024, we conducted a comprehensive search encompassing all articles and reviews published between 2009 and 2023 and utilized the bibliometric online analysis platform, CiteSpace and VOSviewer software to analyze countries/regions, institutions, authors, keywords, and references, used Microsoft Excel 2021 to visualize the trends of the number of articles published by year.

Results

Between 1 January 2009, and 31 December 2023, 3,326 publications on ultrasound combined with microbubble therapy technology were included. There were a total of 2,846 articles (85.6%) and 480 reviews (14.4%) from 13,062 scholars in 68 countries/regions published in 782 journals. China and the United States emerged as the primary contributors in this domain. In terms of publication output and global institutional collaboration, the University of Toronto in Canada has made the most significant contribution to this field. Professor Kullervo Hynynen has achieved remarkable accomplishments in this area. Ultrasound in Medicine and Biology is at the core of the publishing of research on ultrasound combined with microbubble therapy technology. Keywords such as “sonodynamic therapy,” “oxygen,” “loaded microbubbles” and “Alzheimer’s disease” indicate emerging trends in the field and hold the potential to evolve into significant areas of future investigation.

Conclusion

This study provides a summary of the key contributions of ultrasound combined with microbubble therapy to the field’s development over the past 15 years and delves into the historical underpinnings and contemporary trends of ultrasound combined with microbubble therapy technology, providing valuable guidance for researchers.
Parasitism by Cuscuta chinensis is associated with changes in leaf functional traits and hyperspectral characteristics of Eunymus japonicas
Authors: Zhu Jiyou , Liu Yuxuan , Zhang Qinze , Li Longqin , Li Hongyuan
Published: July 2024

Cuscuta chinensis have a significant regulatory effect on plant growth, but the response mechanism of functional traits to the parasitism of C. chinensis and the trade-off relationship between traits and hyperspectral characteristics are not clear. We investigated the functional trait response and hyperspectral characteristics of Euonymus japonicus, the most common urban hedge plant in China, to the parasitism of C. chinensis. The results showed that the parasitism of C. chinensis led to the difference of leaf functional traits: the leaf thickness, stomatal density, and leaf dry matter content were significantly increased, whereas the leaf area, leaf weight, specific leaf area, chlorophyll content index, and leaf tissue density were significantly decreased. Notably, the parasitism of C. chinensis changed the spatial distribution pattern of stomata and promoted the stomata to be evenly distributed. Furthermore, the spectral reflectance of leaves treated with the parasitism of C. chinensis tended to increase. The parasitism of C. chinensis led to the "blue shift" of hyperspectral reflectance of leaves. There was a significant correlation between spectral parameters and leaf functional traits, and leaf biomass accounted for 83% of the variation in reflectance of the water stress band. In general, the parasitism of C. chinensis determines the strategic way of plant utilization of resources and affects the change of plant strategy by affecting the difference of traits. Urban plants were more inclined to invest resources in nutrient storage capacity at the expense of resources investment in photosynthetic capacity and defense mechanism. The plant ecological strategy changed from resource acquisition to resource conservation. This finding comes up with a new strategy that urban tree species can modify the plasticity of functional traits for survival and growth under the interference of parasitic plants.
Relative effects of melatonin and hydrogen sulfide treatments in mitigating salt damage in wheat
Authors: Khan Sheen , Alvi Ameena Fatima , Fatma Mehar , Al-Hashimi Abdulrahman , Sofo Adriano , Khan Nafees A.
Published: July 2024

Soil salinity poses a significant threat to agricultural productivity, impacting the growth and yield of wheat (Triticum aestivum L.) plants. This study investigates the potential of melatonin (MT; 100 µM) and hydrogen sulfide (H2S; 200 µM sodium hydrosulfide, NaHS) to confer the tolerance of wheat plants to 100 mM NaCl. Salinity stress induced the outburst of reactive oxygen species (ROS) resulting in damage to the chloroplast structure, growth, photosynthesis, and yield. Application of either MT or NaHS augmented the activity of antioxidant enzymes, superoxide dismutase, ascorbate peroxidase, glutathione reductase, and reduced glutathione (GSH) levels, upregulated the expression of Na+ transport genes (SOS1, SOS2, SOS3, NHX1), resulting in mitigation of salinity stress. Thus, improved stomatal behavior, gas-exchange parameters, and maintenance of chloroplast structure resulted in enhanced activity of the Calvin cycle enzymes and overall enhancement of growth, photosynthetic, and yield performance of plants under salinity stress. The use of DL-propargylglycine (PAG, an inhibitor of hydrogen sulfide biosynthesis) and p-chlorophenyl alanine (p-CPA, an inhibitor of melatonin biosynthesis) to plants under salt stress showed the comparative necessity of MT and H2S in mitigation of salinity stress. In the presence of PAG, more pronounced detrimental effects were observed than in the presence of p-CPA, emphasizing that MT was involved in mitigating salinity through various potential pathways, one of which was through H2S.
Enhancing kiwifruit flower pollination detection through frequency domain feature fusion: a novel approach to agricultural monitoring
Authors: Pan Fei , Hu Mengdie , Duan Xuliang , Zhang Boda , Xiang Pengjun , Jia Lan , Zhao Xiaoyu , He Dawei
Published: July 2024

The pollination process of kiwifruit flowers plays a crucial role in kiwifruit yield. Achieving accurate and rapid identification of the four stages of kiwifruit flowers is essential for enhancing pollination efficiency. In this study, to improve the efficiency of kiwifruit pollination, we propose a novel full-stage kiwifruit flower pollination detection algorithm named KIWI-YOLO, based on the fusion of frequency-domain features. Our algorithm leverages frequency-domain and spatial-domain information to improve recognition of contour-detailed features and integrates decision-making with contextual information. Additionally, we incorporate the Bi-Level Routing Attention (BRA) mechanism with C3 to enhance the algorithm’s focus on critical areas, resulting in accurate, lightweight, and fast detection. The algorithm achieves a mAP0.5 of 91.6% with only 1.8M parameters, the AP of the Female class and the Male class reaches 95% and 93.5%, which is an improvement of 3.8%, 1.2%, and 6.2% compared with the original algorithm. Furthermore, the Recall and F1-score of the algorithm are enhanced by 5.5% and 3.1%, respectively. Moreover, our model demonstrates significant advantages in detection speed, taking only 0.016s to process an image. The experimental results show that the algorithmic model proposed in this study can better assist the pollination of kiwifruit in the process of precision agriculture production and help the development of the kiwifruit industry.
Genotype × environment interaction: trade-offs between the agronomic performance and stability of durum (Triticum turgidum) wheat to stem-rust resistance in Kenya
Authors: Ogutu Emmaculate A. , Madahana Sammy L. , Bhavani Sridhar , Macharia Godwin
Published: July 2024

Stem rust significantly threatens durum wheat production, often resulting in substantial yield losses. To better understand resistance mechanisms and the stability of durum lines in stem rust-prone environments, this study evaluated 49 durum genotypes over three seasons at the Kenya Agricultural and Livestock Research Organization in Njoro. Utilizing 7 × 7 alpha lattice design, we assessed adult-plant resistance, monitored disease progression through final disease score (FDS) and area under the disease progress curve (AUDPC), and evaluated agronomic performance. Statistical analyses revealed significant seasonal and genotypic effects on FDS, AUDPC, spike length, and grain yield (p≤0.01; p≤0.001), with important genotype-by-season interactions (p≤0.05; p≤0.001). Broad-sense heritability for AUDPC was high at 0.91 and moderate at 0.35 for kernels per spike, underscoring the genetic basis of these traits. Notably, we observed negative correlations between disease parameters and agronomic traits, suggesting potential trade-offs. GGE biplot analysis singled out the first season (main season of 2019) as crucial for evaluating stem rust resistance and identified several durum lines, such as G45 and G48, as consistently resistant across all conditions. Furthermore, this analysis highlighted G45, G48, G176 and G189 as the highest yielding and most stable lines. The discovery of these resistant and high-performing genotypes is critical for enhancing durum breeding programs, helping to mitigate the impact of stem rust and improve yield stability.
Optimal N management affects the fate of urea-15N and improves N uptake and utilization of wheat in different rotation systems
Authors: Ma Quan , Dai Dandan , Cao Yifan , Yu Qiaoqiao , Cheng Xiyang , Zhu Min , Ding Jinfeng , Li Chunyan , Guo Wenshan , Zhou Guisheng , Zhu Xinkai
Published: July 2024

Rice-wheat and maize-wheat rotations are major cropping systems in the middle and lower reaches of Yangtze River in China, where high nitrogen (N) inputs and low N efficiency often exacerbate resource waste and environmental pollution. Due to the changes in factors such as soil properties and moisture content, the N fate and the N utilization characteristics of wheat in different rotations are significantly different. Efficient N management strategies are thus urgently required for promoting maximum wheat yield in different rotation systems while reducing N loss. A 2-year field experiment using isotopic (15N) tracer technique was conducted to evaluate the fate of 15N-labeled urea in wheat fields and the distribution characteristics of N derived from different sources. The wheat yield and N use efficiency under various N rates (180 and 240 kg ha−1, abbreviated as N180 and N240) and preceding crops (rice and maize, abbreviated as R-wheat and M-wheat) were also investigated. The results showed that N240 increased N uptake and grain yield by only 8.77−14.97% and 2.51−4.49% compared with N 180, but decreased N agronomic efficiency (NAE) and N physiological efficiency (NPE) by 14.78−18.79% and 14.06−31.35%. N240 also decreased N recovery in plants by 2.8% on average compared with N180, and increased N residue in soil and N loss to the environment. Compared with that of basal N, the higher proportion of topdressing N was absorbed by wheat rather than lost to the environment. In addition, the accumulation of topdressing N in grain was much higher than that of basal N. Compared with that in R-wheat treatment, plants in M-wheat treatment trended to absorb more 15N and reduce unaccounted N loss, resulting in higher yield potential. Moreover, the M-wheat treatment increased N recovery in 0−20 cm soil but decreased 80−100 cm soil compared with R-wheat treatment, indicating a lower risk of N loss in deeper soil. Collectively, reducing N application rate and increasing the topdressing ratio is an effective way to balance sustainable crop yield for a secure food supply and environmental benefit, which is more urgent in rice-wheat rotation.
The relationship between effort-reward imbalance and quality of working life among medical caregivers: mediating effects of job burnout
Authors: Qi Huang , Hongyan Sun , Song He , Zhihang Zhou , Ruiyin Huang , Youjia Ma , Xia Li
Published: July 2024

Background

To determine the relationship between effort-reward imbalance (ERI) and quality of working life (QWL) among medical caregivers and the mediating role of job burnout.

Methods

This was a cross-sectional survey. A total of 787 medical caregivers at seven hospitals from Sichuan and Chongqing, China, between May to September 2023 were included in this observational study. The General Information Questionnaire, Effort-Reward Imbalance Questionnaire (ERI), Maslach Burnout Inventory-General Survey (MBI-GS), and Quality of Working Life Scale (QWL7-32) were used for data collection. SPSS 26.0 and PROCESSv3.3 were used for all data analyses, including descriptive statistics.

Results

A total of 820 questionnaires were distributed, of which only 787 were valid (return rate; 95.98%). The QWL score of medical caregivers was 126.94 ± 16.69. However, QWL scores were significantly different depending on age, number of children, family support status, department, years of experience, night shift status, number of night shifts per month, number of hours worked per day, monthly income, and occurrence of errors or adverse events (p < 0.05). Furthermore, job burnout and ERI were negatively correlated with QWL (p < 0.01). Job burnout mediated (95% CI = -0.365, −0.260) the relationship between ERI and QWL, accounting for 58.65% of the total effect.

Conclusion

Medical caregivers have a medium level of QWL. Job burnout partially mediates the relationship between ERI and QWL. Medical caregiver managers can improve QWL by directly intervening in occupational stress and indirectly intervening in job burnout.
Exploring adolescent participation in football: a gender-differentiated structural equation model based on the theory of planned behavior
Authors: Zeng Xiancheng , He Wei
Published: July 2024

This paper explores the intersection of gender and sports participation in adolescence, focusing on traditionally male-dominated sports like football. We aim to develop a structural model based on the Theory of Planned Behavior (TPB) to examine gender-differentiated patterns and factors influencing adolescent participation in football. We analyzes data from 1,147 adolescents using Structural Equation Modeling (SEM). The results indicate that a blend of attitudes, subjective norms, perceived behavioral control, and past behavior effectively predicts adolescents’ willingness to engage in football. Moreover, the study investigates the roles of perceived behavioral control, past behavior, and behavioral intentions in actual football participation, uncovering significant gender disparities in the progression from past behavior to intentions and subsequent behavior. This research highlights the complex role of gender in football participation and provides strategic insights for increasing girls’ involvement in the sport. Our study sets the stage for future research on enhancing girls’ participation in football.
Identifying the most crucial factors associated with depression based on interpretable machine learning: a case study from CHARLS
Authors: Li Rulin , Wang Xueyan , Luo Lanjun , Yuan Youwei
Published: July 2024

Background

Depression is one of the most common mental illnesses among middle-aged and older adults in China. It is of great importance to find the crucial factors that lead to depression and to effectively control and reduce the risk of depression. Currently, there are limited methods available to accurately predict the risk of depression and identify the crucial factors that influence it.

Methods

We collected data from 25,586 samples from the harmonized China Health and Retirement Longitudinal Study (CHARLS), and the latest records from 2018 were included in the current cross-sectional analysis. Ninety-three input variables in the survey were considered as potential influential features. Five machine learning (ML) models were utilized, including CatBoost and eXtreme Gradient Boosting (XGBoost), Gradient Boosting decision tree (GBDT), Random Forest (RF), Light Gradient Boosting Machine (LightGBM). The models were compared to the traditional multivariable Linear Regression (LR) model. Simultaneously, SHapley Additive exPlanations (SHAP) were used to identify key influencing factors at the global level and explain individual heterogeneity through instance-level analysis. To explore how different factors are non-linearly associated with the risk of depression, we employed the Accumulated Local Effects (ALE) approach to analyze the identified critical variables while controlling other covariates.

Results

CatBoost outperformed other machine learning models in terms of MAE, MSE, MedAE, and R2metrics. The top three crucial factors identified by the SHAP were r4satlife, r4slfmem, and r4shlta, representing life satisfaction, self-reported memory, and health status levels, respectively.

Conclusion

This study demonstrates that the CatBoost model is an appropriate choice for predicting depression among middle-aged and older adults in Harmonized CHARLS. The SHAP and ALE interpretable methods have identified crucial factors and the nonlinear relationship with depression, which require the attention of domain experts.
Emotional activation in a cognitive behavioral setting: extending the tradition with embodiment
Authors: Hauke Gernot , Lohr-Berger Christina , Shafir Tal
Published: July 2024

The neuroscience-based concept of “embodied cognition” or “embodiment” highlights that body and psyche are closely intertwined, i.e., effects of body and psyche are bidirectional and reciprocal. This represents the view that cognitive processes are not possible without the direct participation of the body. Traditional Cognitive Behavioral Therapy (CBT) addresses emotional processes on a conceptual level (dysfunctional thoughts, beliefs, attributions, etc.). However recent findings suggest that these processes already start at the level of bodily sensations. This opens up a way of working in therapy that includes the level of bodily sensations, where the development of emotional meaning is supported by bottom-up processes. Bidirectionality of embodiment can be effectively exploited by using body postures and movements associated with certain emotions, which we refer to as embodiment techniques, to deepen the physical experience of poorly felt emotions and support the valid construction of emotional meaning. This embodied approach offers several advantages: Prelinguistic or hard-to-grasp aspects can be identified more easily before being processed verbally. It is also easier to work with clients who have limited access to their emotions. Thus, in this paper we describe a new embodied CBT approach to working on the dysfunctional schema, which is based on three modules: body focus, emotional field, and interaction focus. In addition, using specific zones in the space of the therapy-room allows the embodiment of problematic interactions, as well as of power and powerlessness, closeness and distance, etc. Directly experiencing these processes on one’s own body in the protected space of therapy allows faster and deeper insights than would be possible with conversations alone. Finally, the vitalizing power of emotions is used to create coherent action plans and successful interactions. This working method is illustrated by means of a case from practice.
Hippocampal subfield morphology from first episodes of bipolar disorder type II and major depressive disorder in a drug naïve Chinese cohort
Authors: Cong Enzhao , Zhong Yingyan , Wu Mengyue , Chen Haiying , Cai Yiyun , Ling Zheng , Wang Yun , Wen Hui , Hu Yao , Zhang Huifeng , Li Yan , Liu Xiaohua , Zhong Pingfang , Lai Weijie , Xu Yifeng , Wu Yan
Published: July 2024

Introduction

Symptoms during the onset of major depressive disorder [MDD] and bipolar disorder type II [BD-II] are similar. The difference of hippocampus subregion could be a biological marker to distinguish MDD from BD-II.

Methods

We recruited 61 drug-naïve patients with a first-episode MDD and BD-II episode and 30 healthy controls (HC) to participate in a magnetic resonance imaging [MRI] study. We built a general linear model (one-way analysis of covariance) with 22 hippocampal subfields and two total hippocampal volumes as dependent variables, and the diagnosis of MDD, BD-II, and HC as independent variables. We performed pair-wise comparisons of hippocampal subfield volumes between MDD and HC, BD-II and MDD, BD-II and HC with post hoc for primary analysis.

Results

We identified three regions that differed significantly in size between patients and controls. The left hippocampal fissure, the hippocampal–amygdaloid transition area (HATA), and the right subiculum body were all significantly larger in patients with MDD compared with the HC. In the onset of first-episode of MDD, the hippocampal volume increased significantly, especially on the left side comparing to HC. However, we found differences between MDD and BD-II were not statistically significant. The volume of the left HATA and right subiculum body in BD-II was larger.

Conclusions

The sample size of this study is relatively small, as it is a cross-sectional comparative study. In both MDD and BD-II groups, the volume of more left subregions appeared to increase. The left subregions were severely injured in the development of depressive disorder.
Effectiveness of biosimilar pegfilgrastim in patients with lymphoma after high-dose chemotherapy and autologous stem cell transplantation: a real-life study
Authors: Loteta Barbara , Pitino Annalisa , Pitea Martina , Alati Caterina , Tripepi Giovanni , Mico' Maria Caterina , Pellicano' Maria , Cogliandro Francesca , Porto Gaetana , Policastro Giorgia , Utano Giovanna , Delfino Ilaria Maria , Sgarlata Annalisa , Scopelliti Anna , Idato Aurora , Laenza Giovanni , Altomonte Maria , D'Arrigo Graziella , Gori Mercedes , Martino Massimo
Published: July 2024

Objectives

To evaluate the efficacy of biosimilar (BIO) pegfilgrastim (PEG) in lymphoma patients after autologous stem cell transplantation (ASCT).

Methods

86 consecutive lymphoma patients who received BIO/PEG after ASCT were assessed. The primary endpoints of this study were the incidence of febrile neutropenia (FN) and time to neutrophil engraftment.

Results

Most patients were males (67.4%) with a median age of 48 years. FN occurred in 66 patients (76.7%), and most of the fever was grade 1-2. The median time to neutrophil engraftment was 9 days. The incidence of FN differs based on lymphoma type (p-value <0.01) and was higher in non-Hodgkin lymphoma (NHL) than in Hodgkin Lymphoma (HL). No statistical difference was found between NHL and HL regarding the time to reach the neutrophil engraftment. Hospitalization lasted from a minimum of 9 to a maximum of 34 days. The restricted mean time to discharge was 15.9 days (95%CI 14-16), without differences based on lymphoma type.

Conclusion

Although the study has the significant limitation of not being randomized and not having a control arm, it highlights the efficacy and safety of a BIO-PEG formulation in patients with Lymphoma and undergoing ASCT.
Stronger color evasive racial ideologies predict lower likelihood of open adoption placement with same-sex couples
Authors: Reece Brian J. , Jenkins Diana L. , Folger Austin C. , Shaw Daniel S. , Neiderhiser Jenae M. , Ganiban Jody M. , Leve Leslie D.
Published: July 2024

Although the adoption rate among same-sex couples has been increasing, limited research has focused on factors influencing decision making related to placing children with such couples, particularly from the standpoint of birth mothers. Additionally, there is a gap in the literature regarding how biases may influence birth mothers’ decision to place their child with a same-sex couple. This study sought to examine the association between birth mothers’ racial ideologies and their decision to voluntarily place their children with same-sex couples (n = 29) or mother–father couples (n = 354) during the adoption process. Results indicated that birth mothers with stronger color evasive racial attitudes were significantly less likely to place their children with same-sex couples. The need for additional research about the intersections among various forms of bias in the adoption process and the effect of potential interactions between homophobia and racism are discussed. Suggestions for professionals wishing to minimize homophobic and racist bias are provided.
Multiple pathogens co-exposure and associated risk factors among cattle reared in a wildlife-livestock interface area in Kenya
Authors: Manyenya Sophina , Nthiwa Daniel , Lutta Harrison Osundwa , Muturi Mathew , Nyamota Richard , Mwatondo Athman , Watene Grace , Akoko James , Bett Bernard
Published: July 2024

Introduction

Understanding multi-pathogen infections/exposures in livestock is critical to inform prevention and control measures against infectious diseases. We investigated the co-exposure of foot-and-mouth disease virus (FMDV), Brucella spp., Leptospira spp., and Coxiella burnetii in cattle in three zones stratified by land use change and with different wildlife-livestock interactions in Narok county, Kenya. We also assessed potential risk factors associated with the transmission of these pathogens in cattle.

Methods

We identified five villages purposively, two each for areas with intensive (zone 1) and moderate wildlife-livestock interactions (zone 2) and one for locations with low wildlife-livestock interactions (zone 3). We sampled 1,170 cattle from 390 herds through a cross-sectional study and tested the serum samples for antibodies against the focal pathogens using enzyme-linked immunosorbent assay (ELISA) kits. A questionnaire was administered to gather epidemiological data on the putative risk factors associated with cattle’s exposure to the investigated pathogens. Data were analyzed using the Bayesian hierarchical models with herd number as a random effect to adjust for the within-herd clustering of the various co-exposures among cattle.

Results

Overall, 88.0% (95% CI: 85.0–90.5) of the cattle tested positive for at least one of the targeted pathogens, while 41.7% (95% CI: 37.7–45.8) were seropositive to at least two pathogens. FMDV and Brucella spp. had the highest co-exposure at 33.7% (95% CI: 30.9–36.5), followed by FMDV and Leptospira spp. (21.8%, 95% CI: 19.5–24.4), Leptospira spp. and Brucella spp. (8.8%, 95% CI: 7.2–10.6), FMDV and C. burnetii (1.5%, 95% CI: 0.7–2.8), Brucella spp. and C. burnetii (1.0%, 95% CI: 0.3–2.2), and lowest for Leptospira spp. and C. burnetii (0.3%, 95% CI: 0.0–1.2). Cattle with FMDV and Brucella spp., and Brucella spp. and Leptospira spp. co-exposures and those simultaneously exposed to FMDV, Brucella spp. and Leptospira spp. were significantly higher in zone 1 than in zones 2 and 3. However, FMDV and Leptospira spp. co-exposure was higher in zones 1 and 2 than zone 3.

Discussion/conclusion

We recommend the establishment of a One Health surveillance system in the study area to reduce the morbidity of the targeted zoonotic pathogens in cattle and the risks of transmission to humans.
Historic Socio-Hydromorphology Co-Evolution in the Delta of Neretva
Authors: Margeta Jure
Published: July 2024

This study presents the historical sequence of the inter-relationship between climate, sea-level change, hydromorphology, and the society in the “Delta of Neretva”, Croatia. This study aims to support future-oriented planning, since the cumulative impact of climate and mean sea-level changes on the delta hydromorphology and socio-economy is very uncertain and difficult to predict. In particular, the sustainability development of the Delta of Neretva requires a long-range strategy that is complicated to outline. In the proposed approach, hydromorphology is used as a sustainability indicator since it considers both the physical character and water content of the delta and looks at how nature and human activities influence the biophysical system and economy. The direction of delta progression and persistence of socio-hydromorphology are evaluated with the assessment of system entropy generation considering the simple system state function. Such a method overcomes the difficulties posed by top–down and bottom–up approaches, making future scenarios and cumulative impacts visible and understandable to stakeholders. The historical co-evolution results indicate that the delta in the future could become a submerged estuary (rias), that is, a sea bay as a result of the subsequent delta progradation caused by an MSL rise, similar to the progradation during the Holocene, and decreasing sediment deposition due to anthropologic processes in their watershed. Technology (policy) assessment suggests that adaptation measures that gradually support environmental security and sustainable livelihoods, i.e., increase natural order at a society-acceptable cost, are preferable.
Enhanced Nondestructive Testing Using Pulsed Eddy Current and Electromagnetic Ultrasonic Techniques
Authors: Zheng Xinyu , Huang Jing , Luo Ningzhao
Published: July 2024

Owing to the challenging working conditions aboard ships, equipment may develop various defects that traditional nondestructive testing methods cannot fully detect. This study proposes a combined approach using pulsed eddy current and electromagnetic ultrasonic testing for enhanced probe detection. Utilizing COMSOL 6.2 finite-element software, a two-dimensional model of the probe was developed to optimize the probe’s design. Based on these findings, a composite probe was designed and structurally optimized, resulting in improved energy conversion efficiency. An experimental platform was established to evaluate the detection capabilities of the composite detection probes. The results indicate that the composite detection probe, as designed and optimized in this study, is effective in testing materials with various artificial defects and enhances the detection of near-surface defects in materials.
Physically Active Lifestyle Attenuates Impairments on Lung Function and Mechanics in Hypertensive Older Adults
Authors: Brandao-Rangel Maysa Alves Rodrigues , Brill Boris , de Souza Carvalho Edilson , Melamed Dobroslav , Moraes-Ferreira Renilson , Silva-Reis Anamei , Leonardo Patricia Sardinha , Frison Claudio Ricardo , De Angelis Kátia , Vieira Rodolfo P.
Published: July 2024

Aim: Physical activity attenuates hypertension in older adults, but its impact on pulmonary function and mechanics in hypertensive older adults is unknown. The study seeks to understand whether a physically active lifestyle can improve respiratory capacity, the mechanical efficiency of the lungs, and, consequently, the quality of life of these individuals, comparing data between groups of active and sedentary hypertensive older adults. Methods: This is a cross-sectional study. We evaluated 731 older adults, stratified into two initial groups: hypertensive older adults (HE; n = 445) and non-hypertensive older adults (NHE; n = 286). For a secondary analysis, we used the International Physical Activity Questionnaire to sub-stratify HE and NHE into four groups: physically inactive hypertensive (PIH; n = 182), active hypertensive (AH; n = 110), physically inactive non-hypertensive (PINH; n = 104), and active non-hypertensive (ANH; n = 65). Lung function was measured by spirometry, and lung mechanics were assessed by impulse oscillometry. Results: Hypertensive older adults presented reduced lung function compared to non-hypertensive older adults, and physical inactivity accentuated this decline. Regarding pulmonary mechanics, hypertensive older adults had higher resistance of the entire respiratory system (R5 Hz), the central airways (R20 Hz), and peripheral airways (R5–20 Hz), which may trigger bronchoconstriction. Conclusions: Hypertension is associated with impaired lung function and mechanics in older adults, and a physically active lifestyle attenuates these dysfunctions.
Use of Rainwater Harvesting from Roofs for Irrigation Purposes in Hydroponic Greenhouse Enterprises
Authors: Boyacı Sedat , Atılgan Atılgan , Kocięcka Joanna , Liberacki Daniel , Rolbiecki Roman
Published: July 2024

This study was conducted to determine the irrigation water demand due to solar radiation in high-tech greenhouses using hydroponic systems in Turkey’s Mediterranean and continental climates, and to determine the annual water consumption and storage capacity with harvested rainwater. Intensive greenhouse cultivation and the recent increase in modern greenhouse cultivation were important factors in selecting the provinces for the study. The chosen provinces were Antalya and Adana, with a Mediterranean climate, and Afyonkarahisar and Kırşehir, with a continental climate. In this research, depending on the production period, the amount of water consumed per unit of area in greenhouses in Antalya, which has a Mediterranean climate, was determined to be 1173.52 L m−2 per yr−1, and in Adana, it was 1109.18 L m−2 per yr−1. In the provinces of Afyonkarahisar and Kırşehir, where a continental climate prevails, water consumption was calculated to be 1479.11 L m−2 per yr−1 and 1370.77 L m−2 per yr−1, respectively. Storage volumes for the provinces of Antalya, Adana, Afyonkarahisar and Kırşehir were found to be 438.39 L m−2, 122.71 L m−2, 42.12 L m−2 and 43.65 L m−2, respectively. For the provinces of Antalya, Adana, Afyonkarahisar and Kırşehir, the rates of rainwater harvesting and meeting plants’ water consumption were calculated to be 80.79%, 54.27%, 27.47% and 25.16%, respectively. In addition, the amount of water fee savings that could be achieved by rainwater harvesting was calculated to be USD 901.3 per yr−1 for Antalya, USD 835.3 per yr−1 for Adana, USD 247.6 per yr−1 for Afyonkarahisar and USD 210.2 per yr−1 for Kırşehir. As a result, rainwater harvesting will not only provide economic gain to enterprises but will also be important in reducing the negative effects of irregular rainfall regimes caused by climate change on underground and surface water resources. It was also concluded that enterprises should focus on popularizing rainwater harvesting.
Climate Change and Viticulture in Italy: Historical Trends and Future Scenarios
Authors: Alba Vittorio , Russi Alessandra , Caputo Angelo Raffaele , Gentilesco Giovanni
Published: July 2024

(1) Background: The aim of this work was to characterize climatic evolution and change based on multicriteria classification through the dynamics of bioclimatic indices in viticulture across Italy and its regional administrative boundaries, focusing on latitudes and elevations. (2) Methods: This study analyzes climate change influences on Italian viticulture with reference to historical information (1991–2021) and future scenarios (until 2080) primarily based on the SSP2-4.5 and SSP5-8.5 scenarios, taking into account 13 GCMs. (3) Results: The bioclimatic indices have all shown a significant trend in the historical period, with an increase in temperature and a decrease in precipitation, reflecting their effects on the entire Italian territory with respect to the HI, up to 44° N for the CI, and up to 46° N for the DI, regardless of altitude. The future scenarios highlighted a shift towards the warmer classes of the two temperature-based indices (HI and CI) for both SSPs, especially for altitudes up to 900 m a.s.l. The DI-based classification based on the DI remained relatively stable in Italy over time, although DI values will become increasingly negative in the near future. (4) Conclusions: The climate in Italy is warming, especially in the south and in the coastal regions. By 2080, more areas will be “very hot” with “warm nights”. Drought will also increase and have a negative impact on viticulture. These findings spotlight the need for adaptive strategies in viticulture to hold satisfactory productivity under changing climatic conditions.
Long-Term Outcomes of Esophageal Squamous Neoplasia with Muscularis Mucosa Involvement after Endoscopic Submucosal Dissection
Authors: Yu Chen-Huan , Chou Yueh-Hung , Shieh Tze-Yu , Liu Chao-Yu , Wu Jiann-Ming , Hsieh Chen-Hsi , Lee Tzong-Hsi , Chung Chen-Shuan
Published: July 2024

Ambiguity exists over treatment and surveillance strategies after endoscopic submucosal dissection (ESD) for esophageal squamous cell neoplasia (ESCN) with unfavorable histologic features. This study investigated the long-term outcomes of ESD in high-risk ESCN patients. We retrospectively included early ESCN patients treated with ESD at two medical centers in Taiwan between August 2010 and December 2023. Demographic, endoscopic and pathological data were collected. Among 146 patients (mean age 59.17 years) with 183 lesions, 73 (50%) had a history of head and neck cancer (HNC). En bloc and R0 resections were achieved in 100% and 95.6% of the lesions, respectively. The 5-year overall survival (OS), disease-specific survival (DSS) and local recurrence rates were 42.7%, 94.7% and 11%. R0 resections were significantly associated with recurrence in a univariate analysis (HR: 0.19, 95% CI: 0.06–0.66, p = 0.008). Alcohol abstinence was independently associated with lower recurrence (HR: 0.34, 95% CI: 0.16–0.73, p = 0.006). Patients with pT1a-MM (muscularis mucosa invasion) had comparable OS (p = 0.82), DSS (p = 0.617) and recurrence (p = 0.63) rates to those with pT1a-EP/LPM (epithelium/lamina propria invasion). The long-term outcomes of ESCN patients after ESD for expanded indications were satisfactory. ESD could be considered in selected ESCN patients involving the muscularis mucosa, notably among high-risk HNC patients.
Wearable Sensors Based on Miniaturized High-Performance Hybrid Nanogenerator for Medical Health Monitoring
Authors: Wu Jinjing , Lin Xiaobo , Yang Chengkai , Yang Sirui , Liu Chenning , Cao Yuanyuan
Published: July 2024

Wearable sensors are important components, converting mechanical vibration energy into electrical signals or other forms of output, which are widely used in healthcare, disaster warning, and transportation. However, the reliance on batteries limits the portability of wearable sensors and hinders their application in the field of Internet of Things. To solve this problem, we designed a miniaturized high-performance hybrid nanogenerator (MHP-HNG), which combined the functions of triboelectric sensing and electromagnetic power generation as well as the advantages of miniaturization. By optimizing the design of TENG and EMG, the wearable sensor achieved a voltage output of 14.14 V and a power output of 49 mW. Based on the wireless optical communication and wireless communication technologies, the wearable sensor achieved the integration of sensing, communication, and self-powered function, which is expected to realize health monitoring, emergency warning, and rehabilitation assistance, and further extend the potential application value in the medical field.
Acute Pancreatitis in Pediatric Acute Lymphoblastic Leukemia (AcuPA Study): A Nationwide Survey in Poland
Authors: Morawiak Anna , Salamonowicz-Bodzioch Małgorzata , Królak Aleksandra , Kałwak Krzysztof , Owoc-Lempach Joanna , Kowalczyk Jerzy , Zawitkowska Joanna , Szczepański Tomasz , Irga-Jaworska Ninela , Adamkiewicz-Drożyńska Elżbieta , Albrecht Katarzyna , Szmydki-Baran Anna , Balwierz Walentyna , Czogała Małgorzata , Wachowiak Jacek , Derwich Katarzyna , Młynarski Wojciech , Zalewska-Szewczyk Beata , Krawczuk-Rybak Maryna , Sawicka-Żukowska Małgorzata , Styczyński Jan , Kołtan Andrzej , Safranow Krzysztof , Urasiński Tomasz , Ociepa Tomasz
Published: July 2024

Purpose: This study aimed to identify the risk factors for acute pancreatitis (AP) and its impact on outcomes in Polish children treated for ALL. Methods: The study group included 2303 children receiving intensive chemotherapy for ALL. The group was divided into patients with at least one episode of AP and those who did not develop AP after treatment for ALL. Results: The cumulative incidence of AP in the study group was 4.08%. Older age was an independent risk factor for the development of AP (OR = 1.05; 95%CI = 1.006–1.098; p = 0.03). The overall mortality associated with AP was 2.13%. The probabilities of disease-free survival (p-DFS) and event-free survival (p-EFS) in both subgroups were 0.84 vs. 0.86, log-rank p = 0.65 and 0.75 vs. 0.80, log-rank p = 0.12, respectively. A total of 22 out of 94 patients (23.4%) with AP were re-exposed to asparaginase (ASP) during the subsequent treatment phases. Only one patient re-exposed to ASP (4.5%) developed a second episode of AP. There were no significant differences in p-DFS and p-EFS between patients re-exposed and not re-exposed to asparaginase (0.78 vs. 0.86, log-rank p = 0.27 and 0.63 vs. 0.79, log-rank p = 0.09, respectively). Conclusions: The incidence of AP in children with ALL is low and related to patients’ age. The development of AP does not seem to influence p-DFS and p-EFS in children with ALL. Recurrence of AP after re-exposure to asparaginase in patients with ALL and a history of AP is low (4.5%). Re-exposure to asparaginase after the first episode of AP does not improve either p-DFS or p-EFS in children with ALL.