bluuebunny/crossref_metadata_2025 huggingface dataset:
塔吊潜在危险源及防碰撞安全措施探讨
Authors: 晔 肖
Published: April 2022

在中国建筑工程行业快速发展的背景下，各项施工技术全面升级、创新，不仅促进施工质量得以提高，还构筑了更加安全的施工环境。塔吊施工作为建筑工程中重要的施工项目，存在较多的风险点危险源，故需采用科学有效的防碰撞安全措施，构建完善的施工作业环境，不打折扣地执行塔吊安全使用管理规定，是保障塔吊施工安全性的重要方式。因此，论文结合具体工程案例，对塔吊潜在危险源及防碰撞安全措施进行深入的研究与分析，并提出一些合理的意见和措施，旨在清除塔吊作业期间可能存在的安全隐患。
铁路隧道斜井进正洞挑顶施工技术研究
Authors: 红周 李 , 晓华 吴
Published: April 2022

随着中国中西部铁路建设的不断发展，山区特长隧道的设计与施工越来越普遍，而通过斜井进入正洞来增加工作面，由此在缩短工期、提高工效方面已经成为业界的共识，如何确保斜井进正洞挑顶施工的安全高效是一个难点，结合对兰张铁路新乌鞘岭隧道斜井进正洞挑顶施工工艺、注意事项等进行介绍，为同类工程施工提供一定参考。
大体积混凝土结构在土木建筑施工中的技术管理分析
Authors: 爱雪 杨
Published: April 2022

大体积混凝土结构施工非常容易出现裂缝问题，这不利于保障土木建筑的施工质量，因而要提升土木建筑施工的质量必须采取相应的措施防范裂缝问题。论文基于现阶段中国在大体积混凝土结构施工中的裂缝问题进行了分析，并提出了相关的技术管理方法，希望能进一步提升土木建筑的施工质量。
装配式装修在公寓施工中的应用探析
Authors: 胜 余
Published: April 2022

随着工业技术的发展和国民对房产需求的激增，中国住宅行业向工业化方向迈进，在政府大力推广装配式建筑和长租公寓建设背景下，中国装配式装修施工进入快速增长期。装配式装修通过一体化思维与设计、研发以及建造模式相结合，能够有效地加快生产效率、提高产品品质，同时还能够促进经济高质量和可持续发展。对此，论文以装配式装修技术在公寓产品中的创新应用为题，讨论其发展的方向。
禅宗美学在植物景观设计中的应用研究
Authors: 茵 杨
Published: April 2022

禅宗为中国大乘佛教的构成流派之一，禅宗美学是在禅宗思想上演化出的审美意识形态。植物景观设计在中国具有悠久的历史，历史的不同时期，禅宗美学对植物景观设计就产生过或深或浅的影响。禅宗美学在植物景观设计中的应用研究既是一个古老的课题，也是一个崭新的课题。论文针对禅宗美学的概念，植物景观的设计的美学原理及禅宗美学思想指导下的植物景观设计进行了阐述与分析。
Pengembangan Media RatuChemWeb dalam Model Pembelajaran Flipped Classroom untuk Meningkatkan Motivasi dan Hasil Belajar Peserta Didik
Authors: Rahman Andi Sriatu Nurdiyanti , Anwar Muhammad , Wijaya Mohammad
Published: April 2022

This research is a development research that aims to develop RatuChemWeb in the Flipped Classroom learning model to increase students' motivation and learning outcomes on Acid and Base subject which is valid, practical, and effective to be used. The development model used in this study referred to Addie development model, which consisted of several stages, namely analysis, design, development, implementation, and evaluation. RatuChemWeb media that had been developed was conducted the validation stage by the validators/experts and had gone through trials and had been revised by developers to produce learning media which were valid, practical, and effective. The results show that the development of RatuChemWeb media have: (1) the media expert’s validation by 3.96 which is very valid criteria; (2) the material expert’s validation by 3.68 which is very valid criteria. The RatuChemWeb media is stated as practical due to the practicality test related to (1) its implementation in the Flipped Classroom learning model gains an average value of M = 1.98 with the category of being fully implemented, (2) the teacher's response is very positive with a percentage of 98.92% with very practical criteria, and (3) the students' responses are very positive with a percentage of 84.02% with very practical criteria. The media also meets the effective criteria with the results: (1) based on the Wilcoxon test, it obtains the significance value of p-value smaller than (0.000 < 0.05), which means there is a difference in the average students’ learning motivation before and after learning by using the RatuChemWeb media in the Flipped Classroom learning model with the increase of students' learning motivation from 60.83% to 74.72% and (2) the class completeness is 82% and the average value of N-Gain is 77% which is in high category.
Pengembangan E-Modul Asam Basa Berbasis Problem Based Learning melalui Google Classroom pada Sekolah Menengah Kejuruan (SMK)
Authors: Abdullah Asriyani , Danial Muhammad , Anwar Muhammad
Published: April 2022

This research is a development research that aims to develop and produce an acid- base e-module based on problem-based learning through google classroom at a vocational high school (SMK) which has valid, practical, and effective criteria. The development model used in the study refers to the 4D development model, which consists of the definition stage, the design stage, the development stage, and the dissemination stage. The acid-base e-module based on problem-based learning developed was validated by two experts. After being validated, the acid-base e-module based on problem-based learning was piloted on students at grade  X TKJ 1 at SMKN 5 Jeneponto of academic year 2020/2021 with 27 students. The results show that the acid-base e-module based on problem-based learning developed had conducted a validation process, measuring the level of practicality and effectiveness. The e-module is stated as valid based on the results of the e- module validation with an average value of 3.27 (valid). The e-module is stated as practical based on: (1) the implementation of the acid-base e-module based on problem-based learning at an average value of 1.9 (fully implemented), (2) the teacher's response with an average score of 97.12 (very practical), and (3) the students’ responses with an average score of 81.34 (very practical). E-module is stated as effective based on the results of the N-gain test of 0.76 (high) and classical completeness of 85.19%. Therefore, the results of the study indicate that the acid-base e-module based on problem-based learning has valid, practical, and effective qualities. An outline summary of the acid-base e-module based on problem-based learning through Google Classroom contains a glossary, basic competencies, competency achievement indicators, instructions for using e- modules, concept maps, learning activities 1, 2, and 3, evaluation and answer keys.
Pengembangan e-LKPD Berbasis Model Discovery Learning pada Materi Pokok Asam Basa
Authors: Pratama Anugrah , Gani Tabrani , Danial Muhammad
Published: April 2022

This study aims to: (1) determine the process of developing e-LKPD based on the discovery learning model on acid and base materials to improve learning outcomes. (2) determine the level of validity, practicality and effectiveness of e-LKPD based on discovery learning models on acid and base materials to improve learning outcomes. This type of research is Research and Development (R&D). This development research procedure follows the ADDIE model which consists of 5 phases, namely: analysis, design, development, implementation, and evaluation. The results showed that the level of validity of the e-LKPD based on the discovery learning model on the average acid and base material was stated to be very valid and feasible to use. This is based on the results of validation by expert validators with a general validation value of 3.50 or a very valid category. The practicality of the e-LKPD media with the discovery learning model is stated to be practical with a presentation of around 70% - 100%. The e-LKPD media with the discovery learning model is very effective to use. Completeness or achievement of the pretest KKM or those who scored 75 and above were 5 people (13.89%) and increased to 36 student (100%). The developed e-LKPD media contains, (1) title cover, (2) KD and Learning Indicators, (3) brief material, (4) stimulus video, (5) problem formulation column, (6) observation column, (7 ) conclusion column.
THE COLLECTION OF FORAMINIFERA FROM THE UPPER CRETACEOUS DEPOSITS OF MOUNTAINOUS CRIMEAIN THE MSU EARTH SCIENCE MUSEUM’S MONOGRAPH COLLECTION
Authors: Grechikhina Natalya , Krupina Nataliya
Published: April 2022

The article describes the micropaleontological collection of benthic and planktonic foraminifera (No. 145), which has supplied the basis for a research monograph on the Kampan-Maastricht Deposits of the Mountainous Crimea: Biostratigraphy, Paleogeography, Conditions of Establishing. Specimens in the collection characterize five geological sections of the Mountainous Crimea territory. Analysis of distribution of complexes planktonic and benthic foraminifera in each section is carried out. The collection consists of 269 Franke cells, according to 149 specimens; its catalogue runs 106 pages. Detailed descriptions of each Franke cell is given on the labels, in a separate catalogue consisting of 129 pages. The numbering of each geological section is independent, permitting effortless discovery of the descriptions, as well as photos of foraminifera shells in one of the 34 photographic tables in the electronic version of the monograph.
IVAN ALEXEYEVICH DVIGUBSKY: ON THE 250TH ANNIVERSARY OF HIS BIRTH
Authors: Smurov Andrey , Kolotilova Natalia , Maksimov Yuri , Smurova Tatyana , Sochivko Andrey
Published: April 2022

The article discusses the scientific biography of Ivan Alexeyevich Dvigubsky (1771/72-1839/40), Moscow State University’s provost (1826-33), dean of the Department of Physical and Mathematical Sciences, honorary professor (1830) and honorary member of the university, an eminent teacher and naturalist.
Professionalism, Variety and Knowledge Production in the Social Economy
Authors: Hall Peter
Published: April 2022

This keynote address explores the interplay between three forces that will shape the next few years of social economy practice and research. The first is variety, both with respect to existing and emergent social need, and with respect to the multiplicity of organizational forms adopted by social economy actors. The second concerns the forms of knowledge, ranging from instrumental knowledge to reflection and critique, which inform practices in the sector. Knowledge production is itself both enabled and constrained by the third force, professionalism, or the ways we structure the socialization and employment of those working in the sector. With variation an inherent characteristic of the social economy and with the ongoing search for appropriate models of professionalism, our collective knowledge production tasks remain unfinished.Ce discours principal explore les interactions entre trois forces qui vont façonner la pratique et la recherche en économie sociale au cours des prochaines années. La première est la variété, tant par rapport aux besoins sociaux actuels et naissants qu’à la multiplicité de formes organisationnelles adoptées par les acteurs de l’économie sociale. La seconde concerne les types de savoir informant les pratiques dans le secteur, du savoir instrumental jusqu’à la réflexion et la critique. La troisième force, le professionnalisme ou la manière dont on organise le recrutement et la socialisation de ceux et celles qui oeuvrent dans le secteur, permet la production du savoir tout en y imposant certaines contraintes. La variation étant une caractéristique intrinsèque de l’économie sociale, et la quête de modèles de professionnalisme appropriés se perpétuant, il est clair que nos tâches collectives de production du savoir demeurent inachevées.
General Results of Industry 4.0 and Its Components for Businesses
Authors: İhsan YILMAZ Ömer , TAŞLIYAN Mustafa
Published: April 2022

Industry 4.0, which has taken place recently, has brought many innovations and developments with it. With this revolution, technology perceptions and perspectives of individuals and businesses have changed. The technological leaps
that took place after Industry 4.0 have brought to business life the ways of doing business that individuals have never been accustomed to, such as remote working. This and many other changes have created an atmosphere of panic
in some individuals and businesses, and fueled the desire of others to learn and develop. These positive and negative feelings about technological development created an ecosystem, those who adapt to change were offered the opportunity
to work in new and better conditions, and those who opposed change faced extinction. Industry 4.0 has many components. These components lead technology today and make significant contributions to both businesses and individuals.
The aim of this study is to reveal the concept of Industry 4.0 and its components, and to discuss its consequences for businesses. As a result of the study, it has been observed that Industry 4.0 is a promising revolution and the
components and outputs of this revolution can make significant contributions to the business world.
PENGELOLAAN ALOKASI DANA DESA DALAM RANGKA PEMBERDAYAAN MASYARAKAT
Authors: Juliartini  , Sujadi  , Daeng Akung
Published: April 2022

Penelitian ini berjudul “Pengelolaan Alokasi Dana Desa Dalam Rangka Pemberdayaan Masyarakat (Desa Sandik Kecamatan Batulayar Kabupaten Lombok Barat)”. Tujuan dari penelitian ini adalah untuk mengetahui alasan pentingnya Alokasi Dana Desa harus disalurkan ke masyarakat Desa Sandik khususnya bidang pemberdayaan serta untuk mengetahui manfaat dari Pengelolaan Alokasi Dana Desa (ADD) dalam rangka Pemberdayaan Masyarakat di Desa Sandik Kecamatan Batulayar Kabupaten Lombok Barat. Metode penelitian yang digunakan adalah metode penelitian kualitatif dengan mengurai data secara deskriptif. Teknik pengumpulan data dilakukan dengan observasi, wawancara, serta Studi kepustakaan dengan menggunakan teknik analisis data kualitatif model Miles dan Huberman (Emzir: 2012. 129) seperti Reduksi data, Penyajian data dan Penarikan kesimpulan atau verifikasi. Hasil penelitian menunjukan Alokasi Dana Desa dalam rangka pemberdayaan masyarakat di Desa Sandik adalah dengan pemberian bantuan modal usaha untuk pedagang bakulan dan pemberian honor untuk Guru PAUD. Berdasarkan hasil penelitian dan jawaban beberapa informan tentu hal ini sangat bermanfaat bagi masyarakat, disamping untuk tambahan modal pengembangan usaha bakulan juga sebagai dorongan motivasi untuk para pedagang sehingga dengan bantuan tersebut masyarakat Desa Sandik akan lebih mandiri dan dapat memenuhi kebutuhan dasar hidup mereka. Selain itu, Pemberian honor bagi Guru PAUD tersebut sangat berguna untuk para Guru yang memang tidak memiliki pekerjaan lain diluar pekerjaan tersebut, karna selain untuk menambah keperluan belanja sehari-hari juga untuk memberikan dorongan semangat supaya para Guru lebih semangat dalam memberikan pembelajaran bagi para siswanya.
PENGARUH PAD, BELANJA MODAL DAN TPAK TERHADAP PRODUK DOMESTIK REGIONAL BRUTO DI KABUPATEN/KOTA PROVINSI NTB TAHUN 2015-2020
Authors: Savira Fatimah , Wahyunadi  , Fatimah Siti
Published: April 2022

Penelitian ini menguji pengaruh Pendapatan Asli Daerah, Belanja Modal dan Tingkat Partisipasi Angkatan Kerja terhadap Produk Domestik Regional Bruto baik secara parsial maupun secara simultan. Penelitian ini dilakukan pada 10 Kabupaten/Kota Provinsi Nusa Tenggara Barat selama kurun waktu 2015-2020. Data dalam penelitian ini merupakan data sekunder yang diperoleh dari Direktorat Jenderal Perimbangan Keuangan, Kementerian Keuangan Republik Indonesia dan Badan Pusat Statistik Nusa Tenggara Barat. Metode analisis yang digunakan dalam penelitian ini adalah regresi data panel menggunakan model regresi fixed effect yang diolah dengan eviews-10. Hasil penelitian ini menunjukkan bahwa secara parsial variabel Pendapatan Asli Daerah dan Belanja Modal berpengaruh positif dan signifikan terhadap Produk Domestik Regional Bruto Kabupaten/Kota Provinsi Nusa Tenggara Barat selama kurun waktu 2015-2020, sementara variabel Tingkat Partisipasi Angkatan Kerja berpengaruh positif dan tidak signifikan terhadap Produk Domestik Regional Bruto Kabupaten/Kota Provinsi Nusa Tenggara Barat selama kurun waktu 2015-2020. Secara Simultan variabel Pendapatan Asli Daerah, Belanja Modal dan Tingkat Partisipasi Angkatan Kerja berpengaruh signifikan terhadap Produk Domestik Regional Bruto Kabupaten/Kota Provinsi Nusa Tenggara Barat selama kurun waktu 2015-2020
PERANAN DAN TANGGUNG JAWAB SERIKAT PEKERJA DALAM MENCIPTAKAN HUBUNGAN KERJA YANG HARMONIS
Authors: Asyhadie Zaeni , Hadi Adha Lalu , Kusuma Rahmawati
Published: April 2022

Dalam perspektif ketenagakerjaan, iklim berusaha yang kondusif adalah suatu kondisi hubungan kerja yang harmonis di perusahaan dimana pengusaha dan serikat pekerja/buruh bekerja sama atas dasar saling menghormati dan saling memahami kepentingan masing-masing, secara optimal mengedepankan dialog dan musyawarah untuk mencapai mufakat dalam mengatasi perbedaan pendapat dan kepentingan, tidak memaksakan kehendak dengan cara-cara yang melanggar peraturan perundang-undangan untuk mencapai tujuan yang dikehendaki, tidak berprasangka negatif atau buruk terhadap mitra kerjanya.  Untuk dapat menciptakan iklim berusaha yang kondusif sebagaimana diuraikan, diperlukan beberapa hal yang pengusaha dan serikat pekerja/serikat buruh sebagai para pihak pelaku hubungan kerja dalam proses produksi barang dan jasa di tempat kerja harus bersedia dan mampu melaksanakan hal-hal yang Menunjukkan dan melaksanakan sikap kemitraan dalam kegiatan hubungan kerja. Oleh karena itu untuk mencapai keharmonisan dalam menjalin Hubungan kerja sebagaimana yang diuraikan tersebut, tentunya Para pihak ( Pekerja dan Pengusaha ) harus memiliki pemahaman tentang peranan dan tanggung jawab masing-masing dalam menyelenggarakan hubungan kerja.
A FORMAÇÃO DE PROFESSORES DE EDUCAÇÃO FÍSICA PARA AS QUESTÕES DE IDENTIDADE DE GÊNERO E SEXUALIDADE: UMA ANÁLISE CURRICULAR
Authors: Valadares Aila Oliveira , Lima Tatiana Polliana Pinto de
Published: April 2022

A Educação Física é considerada o espaço reservado especificamente para propiciar o aprimoramento da linguagem através da expressão corporal e, para isso, é preciso que os estudantes se permitam experimentar e vivenciar as práticas corporais. No entanto, as questões relacionadas à exclusão e aos preconceitos de gênero podem fazer com que os estudantes rejeitem essa oportunidade de vivência. A intervenção e direcionamento dos professores e da comunidade escolar, como um todo, são fundamentais para combater ou reforçar os estereótipos da sociedade. Neste contexto, ao professor de Educação Física está reservado, mais especificamente, o combate aos preconceitos relacionados às práticas corporais. Diante de tal realidade, e entendendo que para que o professor possa intervir no processo de desconstrução dos preconceitos de gênero nas aulas de educação física ele precisa estar fundamentado e preparado, a presente pesquisa busca responder ao seguinte questionamento: “Como as questões de identidade de gênero e sexualidade são abordadas no currículo da licenciatura em Educação Física da Universidade Estadual de Feira de Santana?” Concebendo que a construção e aplicação de um currículo que vise o respeito à identidade de todas as pessoas é fundamental o presente estudo traz como objetivo principal compreender como se dá a formação para as questões de identidade de gênero e sexualidade na Licenciatura em Educação Física da Universidade Estadual de Feira de Santana. Para tal, foram definidos como objetivos específicos: analisar como as questões da identidade de gênero e sexualidade são abordadas nos documentos oficiais do curso e analisar as práticas pedagógicas sobre gênero e sexualidade a partir das narrativas dos docentes. Para alcançar tais objetivos, pretende-se efetivar uma aproximação com a instituição e curso a serem pesquisados, realizando uma análise do Projeto Pedagógico do Curso, bem como dos planos de curso das disciplinas ofertadas aos estudantes, além de realizar entrevistas semiestruturadas com os docentes que ministram componentes curriculares no curso. Entende-se que tal pesquisa se faz relevante academicamente e socialmente, pois é importante (re)pensar a formação de professores e buscar atualizações nos currículos a fim de garantir que esses professores sejam formados, ainda em seu curso inicial de graduação, para uma atuação consciente que busque problematizar e desconstruir preconceitos. Dessa forma, será possível incorporar uma educação verdadeiramente inclusiva em sua prática, afinal, não se faz educação de qualidade sem uma atuação que vise a equidade e a inclusão de todas as pessoas.
Application of Parallel Importation and Voluntary License in the Covid-19 Vaccines Patent as a Strategy for Handling the Health Emergency Situations in Indonesia
Authors: Tejomurti Kukuh , Pujiyono Pujiyono , Pranoto Pranoto , Pati Umi Khaerah
Published: April 2022

This article examines how the application of Parallel Importation and Voluntary License in the Application of the Covid-19 Vaccine Patent as a Strategy for Handling Health Emergency Situations in Indonesia. The problem of the Covid-19 vaccine happens in many countries around the world, including Indonesia whos trying to find a vaccine that can neutralize the Covid-19 Virus. As a consequence of the tremendous demand for vaccines, the world pharmaceutical industry is encouraged to provide Covid-19 vaccines for the needs of 7.8 billion. This article uses normative legal research with a statute, conceptual, and comparative law approach. The results showed that mechanisms such as parallel importation and voluntary licenses could be reached to procure the Covid-19 vaccine. If parallel importation and voluntary licenses are not successful, then the Government shall take a win-lose approach, such as Compulsory Licensing and Use of Patents by the Government, or initiate an anti-monopoly lawsuit.
The Biological Role of Cervical Cancer Suppressor 3 (CCS-3): Literature Review
Authors: Cristiano Luigi
Published: April 2022

CCS-3 is one of the isoforms of eEF1A1, the key protein of the translation elongation step. Discovered in 2006, it has been the subject of some studies on human cervical cancer cell lines and cervical cancer samples. These studies brought to identify its probable role as a transcriptional co-repressor but other functions are currently unknown. It has also been shown that it is able to inhibit cell growth and induce apoptosis in the tumor cells that downregulate it. Further studies could highlight its functions and its possible usefulness as a tumor marker. This review aims to brief the research about CCS-3 that has been carried out so far.
Humic substances application for the vegetative development of hybrid tomato seedlings (Lycopersicon esculentum L.)
Authors: VACELİK Bruna Aline , BETTONİ Marcelle Michelotti , KIZILDENİZ Tefide
Published: April 2022

It is known that the use of resistant cultivars and mineral nutrition associated with humic substances, such as humic and fulvic acids, can favor plant development, promoting aerial parts and roots growth, being a viable technique for better vegetative development of plants in general, and, consequently, for better final productivity. The aim of this work was to evaluate the effect of the fertilizer Bio Humate®, based on humic substances, in the vegetative development of Justyne® hybrid tomatoes. The experiment was conducted in greenhouses of University of Tuiuti do Paraná/Brazil with a completely randomized experimental design, arranged in a 4 x 2 factorial scheme with three doses of the commercial product’s application (1.5, 2, and 2.5 mL L-1 of Bio Humate®) on three repetitions Justyne® hybrid tomato seedlings that were subjected to samplings at 42nd and 56th days after transplanting (DAT)). The treatments were applied every 14 days, starting at 7 DAT at 42 and 56 DAT. The soil application of the Bio Humate® fertilizer showed better results at 2 mL L-1 of doses for the biometric and biochemical parameters evaluated in the vegetative development of Justyne® hybrid tomatoes, even though the chlorophyll content at 56 DAT is the lowest.
The Optics of Leadership: A Comparative Exploration of Uzbek and Tajik Presidential Posing on Instagram
Authors: Ponczek Cordelia Buchanan
Published: April 2022

How might a leader in Central Asia take a selfie? This paper explores the Instagram accounts of the presidents of Tajikistan and Uzbekistan – two countries with authoritarian regimes and varying information and communications technology – in order to reach conclusions on the evolving role of social media in governance. Instagram offers a forum where the two presidents can project their personal leadership style, draw attention to official events, potentially interact with (or received interaction from) other accounts, and use national identity images as a part of their leadership role. These activities cater to domestic audiences as well as feed into the dynamics within the wider social media sphere. This paper explores how, even though the style and substance of the two leaders’ posts differs greatly, Instagram use opens a door to posturing for a virtual audience.
Rising Civic Awareness through Local Instagram: Young Kazakhstani Russians and Their Belongingness to Kazakhstan
Authors: Zhir-Lebed Marina
Published: April 2022

The Russia-Ukraine conflict raised fears that Kazakhstani Russians outside of Russia could be mobilized by the idea of the Russkiĭ mir (Russian world), which has been actively spread on the Russian-speaking segment of social media. Although Russian- speaking social media are popular in Kazakhstan, the example of young Kazakhstani Russians demonstrates that social media usage strengthens the connection to Kazakhstan rather than to the historical “home” country. Being surrounded by visual and textual information related to Kazakhstani urban centers, local Russian youth begin to envisage and create their version of Kazakhstan based upon personal social media feeds. As a result, their civic awareness and sense of belonging to Kazakhstan raise and allow these young people to navigate and portray their national identity in a positive way.
TIC/Al cermet (ceramics+metal) structuring and composition forming with spontaneous infiltration of aluminum melt into a porous hot titanium carbide frame obtained by the SHS (Self-propagating high temperature synthesis) method
Authors: Latukhin Evgeny , Amosov Evgeniy , Umerov Emil' , Davydov Denis
Published: April 2022

The morphology of structuring and composition forming of the ceramic-metal composite material (cermet) TiC/Al is shown in obtaining it using a new method with spontaneous infiltration of aluminum melt into a porous ceramic frame of titanium carbide TiC synthesized in the combustion mode of the initial mixture of powders (charge) Ti+C, i.e. in the process of self-propagating high-temperature synthesis (SHS).
Investigation of the structure, composition and tribological characteristics of nanostructured monocrystalline coatings obtained by ion plasma technology
Authors: Buyanovskiy Ilya , Levchenko Vladimir , Samusenko Vladimir
Published: April 2022

Synthesis technologies and mechanisms of action of nanostructured monocrystalline coatings using ion-plasma technologies have been viewed. This coating builds up a strong boundary layer on working surfaces of heavily loaded friction units, which provides the lubricant with high antifriction properties generated by triboprocess in boundary lubrication mode.
Democratizing Creative Early Educational Experiences: A Matter of Racial Justice
Authors: Souto-Manning Mariana , Emerson Abby C. , Marcel Gina , Rabadi-Raol Ayesha , Turner Adrielle
Published: April 2022

Inquiring into the democratization of creative early educational experiences through the lens of the politics of belonging, this review of research asks: What does research reveal about creative early educational experiences as they pertain to history, race, and justice? Seeking to better understand the racialization of creative early educational experiences, this review undertakes a transformative justice in education approach, attending to the historical roots of the contemporary racialized politics of belonging. Despite the creativity, improvisation, and imagination displayed historically by Black, Indigenous, and other Communities of Color, findings underscore how creative educational experiences prioritize Eurocentric onto-epistemologies, (re)inscribing inequitable schooling. Creative disruption and Black futurities offer two possible pathways to disrupt the legacy of racism in U.S. early schooling.
Democratizing Creativity by Enhancing Imagery and Agency: A Review and Meta-Analysis
Authors: Karwowski Maciej , Zielińska Aleksandra , Jankowska Dorota M.
Published: April 2022

Creativity is a vital topic of various educational discourses, yet the support it receives within the school system is insufficient. This chapter focuses on four particular ways of making creativity more democratized, salient, and accessible in school settings. We start by exploring the educational benefits of egalitarian theoretical approaches to creativity. Then, we posit that democratization requires an equal focus on the cognitive aspects of creative potential and the motivational sphere of self-perception and self-regulation. Third, analyzing cognitive characteristics, we pay special attention to creative imagery: an understudied yet critical aspect of creative potential. By meta-analyzing available evidence from interventional studies, we show that there are multiple effective approaches to enhancing creative imagery, so—in a sense—supporting creative potential might be democratized as well by going beyond creativity training. Fourth, and finally, we discuss the possibilities of adapting so-called wise interventions for the educational psychology of creativity. We review available evidence of how to strengthen creative confidence and the perceived value of creativity among students, and how to make their creative self-regulation more effective.
Creative Methods for Creativity Research(ers)? Speculations
Authors: Koro Mirka , Tanggaard Lene
Published: April 2022

Creativity forms a part of educational curriculum and is an important element of education research. Clearly, creativity research of the past has made a great impact in the ways in which creativity has been integrated within education and educational practice. Yet how creativity has been studied and how the methodologies of these studies shape produced knowledge and impact educational practice are still rather limited and limiting. This chapter calls for methodological experimentation, various forms of performativity, and creativity in the context of research utilizing speculative wonderings. We situate our arguments in different trends in creativity research and discuss more methodologically diverse, speculative, and creative futures.
Puppy Love: The Legacy of Yi Am’s Paintings in Edo-Period Japan
Authors: Lippit Yukio
Published: April 2022

This essay examines the Japanese reception of the Korean painter Yi Am 李巌(b. 1499), and by extension considers the relationship between ink painting technique and pictorial meaning. In particular, it examines how Yi Am’s unique approach to the painting of puppies with blended washes of ink opened up new interpretive possibilities among Japanese viewers. Although Yi Am’s puppy paintings appear to have been circulating in Japan as early as the seventeenth century, they were misattributed to Chinese painters such as Mao Yi, and Yi Am’s seal was mistaken as belonging to a Japanese monk-painter of the Muromachi period. The monochrome ink puppy paintings of the Kyoto artist Tawaraya Sōtatsu 俵屋宗達(ca. 1600-1640), however, depict the bodies of their canine protagonists with the same wash-based approach found in Yi Am’s works, and appear to have been catalyzed in some way by an encounter with the Korean artist’s paintings. In the case of Sōtatsu, this approach eventually came to be known as tarashikomi, a signature technique of the Rinpa School, and therefore it is no exaggeration to state that Yi Am’s works played a role in inspiring one of the most recognizable techniques of early modern Japanese painting. Although dog and puppy paintings are traditionally linked to auspicious meanings, Sōtatsu’s puppy paintings appear to have been associated within a Zen Buddhist themes, in particular the koan “A Dog Has No Buddha-Nature.” This Zen Buddhist framework of meaning can be gleaned from inscriptions on his paintings by Zen monks such as Isshi Bunshu 一絲文守(1608-1646) and Tangai Musen 丹崖無染(1693-1763). I would propose that the particular wash-based approach of Yi Am and Sōtatsu to this subject was particularly significant in generating this association. The eighteenth-century painter-poet Yosa Buson 与謝蕪村(1716-1784) also based his puppy paintings upon models derived from Yi Am. In the case of Buson, however, the cultural meaning of these works can be gleaned from his haikai poetry, in particular a poem accompanying a Maruyama Okyo 円山応挙(1733-1795) painting of a puppy that associates its inky body with the interiority of a poetic subject. The final case study examined in this essay is Itō Jakuchū 伊藤若冲(1716-1800). Jakuchū left a number of puppy paintings that embody Zen Buddhist themes in highly sophisticated ways. Because he was close to Tangai Musen, it is likely that he was aware of Sōtatsu’s puppy paintings, and indirectly familiar with those of Yi Am. Thus the case could be made that Yi Am’s wash-based technique opened up a new horizon of interpretive possibility among Japanese painters extending from Sōtatsu to Jakuchū.
Regulation of endometrial NF-κB expression in patients with PCOS undergoing total embryo freezing
Authors: Karakus Cemil , Turktekin Nurettin , Ozyurt Ramazan
Published: April 2022

Background: To investigate Nuclear Factor kappa B (NF-κB) expression pattern in the endometrial samples taken on the day of egg collection in women with polycystic ovarian syndrome (PCOS)scheduled for total embryo freezing due to the risk of ovarian hyperstimulation syndrome (OHSS). Methods: Forty women with PCOS scheduled for total embryo freezing due to the risk of ovarian hyperstimulation syndrome were included in the study. Twenty-five infertile women who decided to freeze all of their embryos for any reason other than PCOS were utilized as the control group. Endometrial sampling was performed from all patients in both groups immediately following the egg collection. Five fertile women with at least two children constituted the second control group. Endometrial sampling was performed from fertile patients during the mid-luteal phase. After immunohistochemical staining of endometrial samples with NF-κB/p65, the intensity of endometrial NF-κB/p65 expression was measured utilizing the H-score method. Results: NF-κB/p65 immunoreactivity was detected in both luminal and glandular endometrial cells from all samples. The mean H-score of endometrial NF-κB/p65 expression in the PCOS group was significantly increased compared to age and Body mass index (BMI) matched control group and fertile controls. NF-κB/p65 immunoreactivity of the control and fertile groups were found to be similar. There was no statistically significant difference in the mean H-score of endometrial NF-κB/p65 expression between the control and fertile groups. A positive and significant correlation was found between H-score values of NF-κB and E2 (estradiol), endometrial thickness, total oocyte count and total follicle stimulating hormone (rFSH) dose on human chorionic gonadotropin (hCG) day. Similarly, a strong positive correlation was found between serum testosterone, insulin levels, Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) values and NF-κB values. In addition to progesterone values on hCG day, no significant correlation was found between other parameters and NF-κB. Conclusions: Increased endometrial NF-κB/p65 expression may contribute to the diminished reproductive potential of women with PCOS undergoing total embryo freezing.
Real-life experience with antenatal glucocorticoid administration in premature pregnancies complicated by diabetes mellitus
Authors: Dumitrescu Anca-Gabriela , Salmen Teodor , Furtunescu Florentina , Berceanu Costin , Grigoriu Corina , Bohîlțea Roxana-Elena , Popescu Simona Daniela
Published: April 2022

Background: Diabetes mellitus (DM) in pregnancy is associated with an increased risk of premature birth, which therefore increases the risk of acute respiratory distress syndrome (ARDS) of the neonate and is associated with high morbidity and mortality of the newborn. The administration of glucocorticoids to the mother before premature birth decreases the risk of neonatal complications. However, the data regarding the administration of this therapy to mothers with DM is limited. Clinical guidelines recommend treating them in the same manner as the non-DM women, even if there is no recent data to support the benefit in this subpopulation. The aim of this study is to evaluate the real-life effects of glucocorticoid administration on the maternal and fetal prognosis of pregnancies complicated with DM. Material and methods: A retrospective study was conducted on 67 pregnant females who were admitted to the Obstetrics & Gynecology Department of The Emergency University Hospital of Bucharest between December 2016–March 2021, and who received corticosteroid before prematurely giving birth to 70 newborns. There was a group of 33 mothers with DM and a second group with 34 non-DM pregnant women selected for control of glucocorticoids’ real-life administration in the high risk for premature birth population. Results: The administration of glucocorticoids was not restricted by the presence of DM; 78% of the mothers with DM and 79.41% of the mothers without DM received one course of antenatal glucocorticoids for fetal lung maturation (p = 0.6). The incidence of ARDS differs between groups was statistically insignificant: 35.29% in the DM group versus 30.55% in the control group (p = 0.8). There were similar cases of maternal complications such as pregnancy-induced hypertension (PIH), or preeclampsia in the two groups. These findings suggest that glucocorticoid therapy is effective for premature newborns from pregnancies with DM and does not negatively impact the complication rate of the mothers, sustaining their administration in these cases. Conclusions: The administration of antenatal glucocorticoids before premature birth is not influenced by the presence of DM regarding Apgar score at 1 and 5 minutes, the incidence of ARDS, but there were differences such as more large for gestational age (LGA) newborns and neonatal hypoglycemia in the DM group. Considering the low number of patients enrolled from a single-center, future multicentric studies are needed. It is important to emphasize that this study’s findings reflect the local practice and cannot be generalized.
ART outcomes during the COVID-19 pandemic
Authors: Chamani Isaac J. , Grifo James , Chung Monica S. , McKenzie Laurie J. , McCulloh David H. , Gibbons William E. , Licciarid Frederick L.
Published: April 2022

Background: To evaluate whether the ongoing coronavirus disease 2019 (COVID-19) pandemic has had an impact on assisted reproductive technology (ART) outcomes and assess the possible role of geographic differences in the pandemic’s trajectory on these outcomes. Methods: Multi-center retrospective cohort study involving patients who underwent oocyte cryopreservation, in vitro fertilization (IVF), embryo cryopreservation, or frozen euploid embryo transfer in 2019 and 2020 at two academic fertility centers located in regionally distinct areas of the US with high coronavirus infection rates. Patients were screened for infectious symptoms, exposure to sick contacts, and fevers, and tested with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) polymerase chain reaction testing within 5 days of oocyte retrieval. The primary outcomes were the number of oocytes retrieved, embryos fertilized, blastocyst or euploid embryos produced in oocyte retrieval and IVF cycles, and rates of embryo implantation, biochemical pregnancy or no pregnancy following frozen embryo transfer (FET). Results: We found no consistent significant differences in the number of oocytes retrieved, embryos fertilized, blastocysts or euploid embryos produced at either institution over the study period. Furthermore, we did not detect any differences in FET outcomes, including rates of embryo implantation, biochemical pregnancy, or no pregnancy, at either institution during the study time period. Conclusions: There were no significant differences in ART outcomes in patients who received fertility treatment during the pandemic at our centers. Patients and providers can be reassured that with proper testing, sanitizing, and distancing measures, treatments can continue safely during the pandemic without compromising outcomes.
Intraoperative predictive model for the detection of metastasis in non-sentinel axillary lymph nodes
Authors: García-Mejido José Antonio , Sanchez-Sevilla Miguel , García-Jimenez Rocio , Fernández-Palacín Ana , Antonio-Sainz José
Published: April 2022

Background: To design a software-applied predictive model relating patients clinical and pathological traits associated with sentinel lymph-node total tumor load to individually establish the need to perform an axillary lymph-node dissection. Methods: Retrospective observational study including 127 patients with breast cancer in which a sentinel lymph-node biopsy was performed with the one step nucleic acid amplification method and a subsequent axillary lymph-node dissection. We created various binary multivariate logistic regression models using non-automated methods to predict the presence of metastasis in non-sentinel lymph-nodes, including Log total tumor load, immunohistochemistry, multicentricity and progesterone receptors. These parameters were progressively added according to the simplicity of their evaluation and their predictive value to detect metastasis in non-sentinel lymph-nodes. Results: The final model was selected for having maximum discriminatory capability, good calibration, along with parsimony and interpretability. The binary logistic regression model chosen was the one which identified the variables Log total tumor load, immunohistochemistry, multicentricity and progesterone receptors as predictors of metastasis in non-sentinel lymph-nodes. Harrell’s C-index obtained from the area under the curve of the predicted probabilities by Model 4 was 0.77 (95% CI, 0.689–0.85; p < 0.0005). Conclusions: the combination of total tumor load, immunohistochemistry, multicentricity and progesterone receptors can predict 77% of patients with metastasis in non-sentinel lymph-nodes and said prediction may be made intraoperatively in a feasible manner.
Virus infection and direct-acting antivirals in pregnancy
Authors: Huang Xuan , Tang Jing
Published: April 2022

Objective: Antiviral therapy during pregnancy has always presented difficulties in clinical practice. This review covers the safety and efficacy of the direct use of antivirals during pregnancy. Mechanism: We conducted literature research to summarize the available evidence on the use of direct-acting antivirals during pregnancy for infections due to influenza, hepatitis B and C, human immunodeficiency, herpes simplex virus, cytomegalovirus, varicella-zoster virus, Ebola, and Zika viruses, and human coronavirus. Findings in brief: To support further the rational use of antivirals during pregnancy, the discussion includes the influence of pregnancy on pharmacokinetics, safety, and transplacental permeability, and the protection of mothers and children from vertical transmission. Conclusion: Data on the use of antiviral drugs during pregnancy are currently insufficient. Promoting research on the ethics of drug experimentation, and pharmacokinetics, drug metabolism, and pharmacological effects of pregnancy, is essential to improve the care of pregnant women and even save lives during current and future outbreaks.
Potential SARS-CoV-2 nonstructural proteins inhibitors: drugs repurposing with drug-target networks and deep learning
Authors: Azmoodeh Shayan K. , Tsigelny Igor F. , Kouznetsova Valentina L.
Published: April 2022

Background: In the current COVID-19 pandemic, with an absence of approved drugs and widely accessible vaccines, repurposing existing drugs is vital to quickly developing a treatment for the disease. Methods: In this study, we used a dataset consisting of sequences of viral proteins and chemical structures of pharmaceutical drugs for known drug–target interactions (DTIs) and artificially generated non-interacting DTIs to train a binary classifier with the ability to predict new DTIs. Random Forest (RF), deep neural network (DNN), and convolutional neural networks (CNN) were tested. The CNN and RF models were selected for the classification task. Results: The models generalized well to the given DTI data and were used to predict DTIs involving SARS-CoV-2 nonstructural proteins (NSPs). We elucidated (with the CNN) 29 drugs involved in 82 DTIs with a 97% probability of interaction, 44 DTIs of which had a 99% probability of interaction, to treat COVID-19. The RF elucidated 6 drugs involved in 17 DTIs with a 90% probability of interacting. Conclusions: These results give new insight into possible inhibitors of the viral proteins beyond pharmacophore models and molecular docking procedures used in recent studies.
Δ9-Tetrahydrocannabinol (Δ9-THC) Improves Ischemia/Reperfusion Heart Dysfunction and Might Serve as a Cardioprotective Agent in the Future Treatment
Authors: Banaszkiewicz Marta , Tarwacka Paulina , Krzywonos-Zawadzka Anna , Olejnik Agnieszka , Laprairie Robert , Noszczyk-Nowak Agnieszka , Sawicki Grzegorz , Bil-Lula Iwona
Published: April 2022

Background: Ischemia/reperfusion (I/R) is a pivotal mechanism of organ injury during clinical stetting for example for cardiopulmonary bypasses. The generation of reactive oxygen species (ROS) during I/R induces oxidative stress that promotes endothelial dysfunction, DNA dissociation and local inflammation. In turn, those processes induce cytokine release, resulting in damage to cellular structures and cell death. One of the major psychoactive compounds of Cannabis is delta-9-tetrahydrocannabinol (Δ9-THC), which is known as an anti-inflammatory mediator. Our research aimed to test if Δ9-THC may be protective in the treatment of cardiovascular system dysfunction arising from I/R heart injury. Methods: Two experimental models were used: isolated rat hearts perfused with the Langendorff method and human cardiac myocytes (HCM) culture. Rat hearts and HCM underwent ex vivo/chemical in vitro I/R protocol with/without Δ9-THC treatment. The following parameters were measured: cell metabolic activity, morphology changes, cell damage as lactate dehydrogenase (LDH) activity, ceramide kinase (CERK) activity, ROS level, total antioxidant capacity (TAC) and heart hemodynamic parameters. Results: Δ9-THC protected the heart, as evidenced by the improved recovery of cardiac function (p < 0.05, N = 3–6). Cells subjected to I/R showed lower cytoplasmic LDH activity, and 10 μM Δ9-THC treatment reduced cell injury and increased LDH content (p = 0.019, N = 6–9). Morphology changes of HCM-spherical shape, vacuolisation of cytoplasm and swollen mitochondria—were inhibited due to Δ9-THC treatment. I/R condition affected cell viability, but 10 μM Δ9-THC decreased the number of dead cells (p = 0.005, N = 6–9). The total level of CERK was lower in the I/R group, reflecting oxidative/nitrosative stress changes. The administration of Δ9-THC effectively increased the production of CERK to the level of aerobic control (p = 0.028, N = 6–9). ROS level was significantly decreased in I/R cells (p = 0.007, N = 6–8), confirming oxidative stress, while administration of 10 μM Δ9-THC enhanced TAC in cardiomyocytes subjected to I/R (p = 0.010, N = 6–8). Conclusions: Δ9-THC promotes the viability of cardiomyocytes, improves their metabolic activity, decreases cell damage and restores heart mechanical function, serving as a cardioprotective. We proposed the use of Δ9-THC as a cardioprotective drug to be, administered before onset of I/R protocol.