bluuebunny/crossref_metadata_2025 huggingface dataset:
Validasi Tata Laksana Pelatihan Psychological Frist Aid untuk Meningkatkan Self-Efficacy Guru Melalui Virtual Synchronous Learning
Authors: Ainurizan Ridho Rahmatulloh  , Ratri Pratiwi  , Rahimatussalisa
Published: July 2024

Kebutuhan akan program preventif terhadap gangguan kesehatan mental terus bertambah seiring dengan meningkatnya jumlah permasalahan psikologis siswa. Kondisi tersebut diperparah dengan rendahnya self-efficacy guru. Salah satu peluang dalam menghadapi permasalahan tersebut adalah dengan mengembangkan program preventif yang mudah dan sederhana melalui pemanfaatan teknologi internet. Penelitian ini bertujuan untuk melakukan validasi tata laksana psychological frist aid menggunakan synchronous learning dan melihat efektivitas dalam meningkatkan self-efficacy pada guru. Metode penelitian dilakukan dengan eksperimen one group pretest-posttest design melalui virtual synchronous learning. Partisipan pada penelitian ini merupakan guru yang berjumlah 24 orang (N=24). Metode analisis data menggunakan wilcoxon matched-paired signed test. Hasil penelitian ini menunjukan pelatihan tata laksana psychological firs aid melalui virtual synchronous learning valid dan efektif untuk meningkatkan self-efficacy guru dalam memberikan dukungan awal kepada siswa yang mengalami gangguan psiklogis. Penggunaan virtual synchronous learning dalam pelatihan tetap dapat memberikan manfaat ketika dapat membangun komunikasi interaksi dan memberikan ruang untuk diskusi.
Kata kunci: psychological frist aid, guru, synchronous learning, efikasi diri
Analisis Dimensi Self-Harm Dalam Pandangan Islam
Authors: Mil Silvie , Nurul Fadhilah  , Fetriyah Amanda  , Fakhira Alyaa  , Nadia Dwinanda  , Ikfina Kamalia
Published: July 2024

Perilaku self-harm berbahaya bagi fisik dan mental dan saat ini fenomena tersebut semakin banyak terjadi di kalangan remaja. Penelitian ini bertujuan menganalisa dimensi self -harm dalam pandangan Islam dan penanganannya. Penelitian dilakukan dengan metode studi literatur. Terdapat empat dimensi utama dari perilaku self-harm yaitu dimensi kognitif, lingkungan, biologis dan dimensi afektif. Dalam pandangan Islam perilaku menyakiti diri sendiri termasuk kedalam tindakan zalim karena menganiaya diri sendiri. Pandangan Islam memberikan anjuran agar menjauhi perilaku menyakiti diri sendiri dengan berzikir, senantiasa bersyukur, bersabar dan sholat. Masing-masing dimensi memiliki penanganan bidang konseling masing-masing dan dapat bersinergi cara pandangan Islam yang lebih menyorot pada pencegahan perilaku self-harm tersebut. Diharapkan dengan memahami self-harm dengan pandangan Islam dapat meningkatkan kesadaran masyarakat khususnya remaja untuk menghindari self-harm dan mendorong upaya untuk menyediakan sumberdaya yang diperlukan dalam menanganinya.
Kata kunci: self-harm, pandangan islam, bimbingan dan konseling
Hubungan Efikasi Diri Dengan Stres Akademik Pada Mahasiswa Akhir
Authors: Rayhan Deta Maulana  , Ramon Ananda Paryontri
Published: July 2024

Tujuan penelitian ini adalah mengetahui hubungan efikasi diri dengan stress akademik mahasiswa Universitas Muhammadiyah Sidoarjo. Metode penelitian digunakan yaitu metode kuantitatif korelasional dengan jumlah subjek sebanyak 7.872 mahasiswa  penentuan sampel dikembangkan oleh Isaac dan Michael digunakan tingkat 5% sebanyak 334 mahasiswa. Adapun pengambilan sampel penelitian yaitu dengan teknik probability sampling yang menggunakan proposionate stratifield random sampling. Teknik pengukuran skala penelitian ini menggunakan model skala Likert. Teknik analisis data menggunakan korelasi product moment. Hasil penelitian menunjukkan terdapat hubungan negatif dan signifikan antara efikasi diri dengan stress akademik tingkat korelasi yang kuat. Semakin tinggi tingkat efikasi diri yang dimiliki mahasiswa maka semakin stress akademik. Hasil penelitian ini digunakan sebagai acuan positif perencanaan sebelum melakukan pembelian produk di kelas. Berdasarkan penelitian yang saya teliti disimpulkan bahwa diketahui terdapat hubungan efikasi diri dengan stres akademik pada mahasiswa tingkat akhir Universitas Muhammadiyah Sidoarjo dan berdasarkan ke efektifan dari efikasi diri terhadap stres akademik sebesar 44%.
Kata kunci: efikasi diri, stres akademik, mahasiswa akhir
School Engagement and Academic Resilience of High School Students in Klungkung Regency Bali
Authors: Zarinathi Komang Merisa Naraswari , Huwae Arthur
Published: July 2024

This study explores the correlation between school engagement and academic resilience among high school students in Klungkung Regency, Bali, using a quantitative approach with a correlational analysis design. 243 students from five high schools were selected via simple random sampling. Measures included the School Engagement Measure (SEM)-MacArthur (α = 0.851) and the Academic Resilience Scale-30 (ARS-30) (α = 0.884). Hypothesis testing revealed a Pearson correlation value of 0.615, with a significance level of 0.000 (p<0.01), These findings demonstrate that school engagement is a factor that significantly correlates with academic resilience among high school students in Klungkung Regency, Bali.
Keywords: school engagement, academic resilience, high school students.
Pengembangan Model Supervisi Blended Pada Layanan Bimbingan dan Konseling untuk Meningkatkan Kinerja Guru
Authors: Marina Sandra  , Dwikurnaningsih Yari , Waruwu Marinu
Published: July 2024

Penelitian ini bertujuan mengembangkan model supervisi blended pada layanan BK untuk meningkatkan kinerja Guru BK. Metode yang digunakan adalah penelitian dan pengembangan model Borg & Gall sampai pada tahapan ke lima. Teknik pengumpulan data menggunakan angket, studi dokumentasi serta wawancara. Hasil penelitian menghasilkan model supervisi Blended pada layanan bimbingan dan konseling yang terdiri dari: buku model, dan buku panduan bagi supervisor dan Guru BK. Berdasarkan hasil validasi ahli yang dilakukan ahli supervisi bimbingan dan konseling menyatakan bahwa model supervisi blended pada layanan bimbingan dan konseling ini memiliki kategori baik (79,3%), pada validasi ahli yang dilakukan oleh ahli teknologi informasi menyatakan desain media dan buku panduan berada pada kategori sangat baik (90%). Pada uji coba terbatas yang dilakukan terhadap kepala sekolah dan Guru BK berada pada semua aspek dengan kategori sangat baik 85,83% yang dapat diartikan bahwa model supervisi blended efektif untuk meningkatkan kinerja Guru BK.
Kata kunci: model supervisi blended, layanan bimbingan dan konseling, kinerja guru
Self-esteem and Resilience Among Students Affected by Toxic Relationships
Authors: Cindy Priscila Pantjo’u  , Ratriana Yuliastuti Endang Kusumiati
Published: July 2024

The research aims to determine the levels of self-esteem and resilience among university students who are victims of toxic relationships throughout Indonesia. This study is of a quantitative nature. The research subjects consisted of 207 students who have experienced toxic relationships. Subjects were asked to fill out an Informed Consent form as part of the research protocol. The results indicate that self-esteem is not high in cases of toxic relationships; instead, it negatively affects resilience in students involved in toxic relationships. The conclusion of the study is that the hypothesis is rejected, meaning there is no relationship between self-esteem and resilience.
Keywords: self-esteem, resilience, university students who are victims of toxic relationship
Peran Kepala Sekolah dan Wali Kelas dalam Pelaksanaan Bimbingan dan Konseling di SMP Negeri 10 Sumedang
Authors: Hafiyani Silmi , Uman Suherman
Published: July 2024

Pelaksanaan bimbingan dan konseling yang efektif membutuhkan komitmen dalam bentuk kolaborasi dari berbagai pihak dalam memfasilitasi kebutuhan siswa. Tujuan penelitian ini adalah terwujudnya peran kepala sekolah dan wali kelas yang memfasilitasi pengembangan potensi dan kebutuhan siswa. Penelitian ini menggunakan pendekatan kualitatif dengan metode deskriptif menggunakan instrument pengumpulan data wawancara, observasi, dan dokumentasi. Subjek penelitian adalah guru bimbingan dan konseling/konselor sekolah, kepala sekolah, dan wali kelas di SMP Negeri 10 Sumedang. Teknik analisis data menggunakan reduksi data, penyajian data, dan penarikan kesimpulan. Uji validitas data menggunakan sumber triangulasi. Hasil penelitian ini mengungkap bahwa pelaksanaan bimbingan dan konseling sudah berjalan cukup optimal, walaupun memiliki keterbatasan dalam jumlah personel guru bimbingan dan konseling yang lebih sedikit daripada jumlah siswa secara keseluruhan. Kesimpulan penelitian ini menyatakan keberhasilan pelaksanaan bimbingan dan konseling di sekolah sangat bergantung pada sinergitas dan kerja sama semua personel sekolah untuk mencapai tujuan bimbingan dan konseling dengan optimal.
Kata kunci: pelaksanaan bimbingan dan konseling, kolaborasi, kepala sekolah, wali kelas
Penerapan Teknik Self Management Untuk Meningkatkan Kedisiplinan Belajar Siswa Sekolah Menengah Atas (SMA): Systematic Literature Review
Authors: Khairani Syam Br Manurung  , Nefi Darmayanti
Published: July 2024

Disiplin belajar adalah sebagai suatu jenis pengendalian diri siswa mentaati peraturan dan ketentuan sekolah untuk mencapai kondisi yang lebih baik. Salah satu upaya Guru BK di sekolah yakni melalui penerapan teknik self management. Tujuan dari penelitian ini dilakukan untuk mengkaji efektifnya teknik self management untuk meningkatkan kedisiplinan belajar siswa. Metode penelitian yang digunakan yakni literature review dengan menggunakan 1464 artikel kemudian diseleksi menjadi 10 artikel menggunakan Google Scholar dengan kriteria terbit minimal 10 tahun terakhir, mulai dari tahun 2014 sampai dengan 2024, dengan kata kunci teknik self management, kedisiplinan belajar, dan siswa SMA. Hasil penelitian ini menemukan bahwa penerapan teknik self management sangat efektif digunakan untuk meningkatkan kedisiplinan belajar siswa. Kesimpulan dari penelitian ini adalah teknik self management membantu siswa meningkatkan kemampuan untuk lebih disiplin melalui cara mengubah perilaku yang dipengaruhi oleh pikiran, perasaan dan mengurangi perilaku yang tidak pantas dan mengganggu.
Kata kunci: kedisiplinan belajar, teknik self management, siswa SMA
Intervensi Pemaafan Pada Lansia Yang Tidak Bisa Menerima Menantunya (Studi Kasus Intervensi)
Authors: F Oiladang Nona Apungchris , Siswanto  , Daniel Purwoko Budi Susetyo
Published: July 2024

Masa tua cenderung melibatkan perubahan dan penyesuaian, terutama saat anak menikah. Beberapa lansia mungkin kesulitan menerima menantunya karena berbagai faktor, yang dapat menyebabkan konflik dan stres dalam keluarga. Tujuan penelitian untuk menganalisis efektivitas intervensi pemaafan terhadap lansia yang mengalami kesulitan menerima menantunya. Metode penelitian yang digunakan adalah kualitatif dengan pendekatan studi kasus, melibatkan partisipan perempuan berusia 78 tahun, dengan melakukan wawancara dan observasi. Data yang terkumpul kemudian dianalisis, hasil analisis menunjukkan bahwa intervensi pemaafan berhasil membantu lansia untuk memaafkan diri sendiri dan menantunya. Sebelum intervensi, partisipan kesulitan membicarakan menantunya bahkan enggan menyebutkan namanya. Namun, setelah intervensi, sikap partisipan berubah, bahkan ia mulai berkomunikasi melalui video call dan menyebut menantu dengan panggilan yang lebih akrab. Sehingga, intervensi pemaafan memberikan dampak positif pada kemampuan lansia untuk memaafkan diri dan orang lain, serta menghasilkan perubahan dalam kedekatan emosional dan hubungan interpersonal mereka.
Kata kunci: pemaafan, lansia, menantu, psikososial, penyesuaian diri
Actualization Of Parenting and Teacher Collaboration in Instilling the Character of Early Childhood Responsibility
Authors: Rizka Latifa
Published: July 2024

This study aims to analyze more deeply about the actualization of parenting collaboration between parents and teachers in instilling the character of responsibility in children. A phenomenological approach was utilized to delve into the perspectives of the participants involved. Data were analyzed using the model proposed by Milles, Huberman, and Saldana, encompassing data collection, data condensation, data presentation, and drawing conclusions. The research findings indicate that collaboration between parents and teachers in instilling a sense of responsibility in early childhood can create an environment conducive to the formation of responsible values in children. Through close cooperation, children can comprehend the importance of being accountable for their actions and decisions, with parents serving as primary role models at home and teachers reinforcing these values in the school environment.
Keywords: parent and teacher collaboration, character education parenting, responsibility, early childhood
Hubungan Antara Kontrol Diri Dan Kebiasaan Game Online Siswa Dengan Perilaku Agresif Pada Sekolah Menengah Atas (SMA)
Authors: Farida  , Imam Pribadi  , Muhammad Irham Zainuri  , Ainul Fahmi  , Septya Suarja
Published: July 2024

Perilaku agresif di kalangan pelajar merupakan masalah yang seringkali menjadi fokus perhatian dalam bidang pendidikan dan psikologi. Dalam upaya untuk mengatasi dan mencegah perilaku agresif, penting untuk memahami faktor-faktor yang mempengaruhinya. Penelitian ini bertujuan untuk menguji secara empiris hubungan antara kontrol diri dan kebiasaan game online dengan perilaku agresif pelajar. Penelitian ini menggunakan metode kuantitatif. Populasi dalam penelitian ini adalah seluruh pelajar kelas XI IPS I, XI IPS II, XII IPS I, XII IPS II SMAN 10 Luwu dengan jumlah populasi sebanyak 122 siswa. 122 populasi akan diplih secara acak oleh peneliti. Analisis data menggunakan regresi linear sederhana. Hasil dalam penelitian ini ialah bahwa kontrol diri relative tidak memiliki hubungan yang signifikan terhadap perilaku agresif siswa. Kebiasaan game online memiliki hubungan yang signifikan terhadap perilaku agresif siswa SMA. Ketika siswa mempunyai kemampuan kontrol diri yangh baik, maka dapat mengurangi perilaku agresif yang timbul akibat terlalu sering bermain game online.
Kata kunci: kontrol diri, kebiasaan game online, perilaku agresif pelajar
Efektivitas Layanan Bimbingan Kelompok Dengan Teknik Assertive Training Untuk Meningkatkan Komunikasi Interpersonal Siswa MTsN 1 Medan
Authors: Ayidah Nasution  , Alfin Siregar
Published: July 2024

Tulisan ini bertujuan untuk menguji coba layanan bimbingan kelompok menggunakan teknik assertive training untuk meningkatkan komunikasi interpersonal siswa. Penelitian ini menggunakan pendekatan Quasi Experimental desain Pre-Test Post-Test Control group. Partisipan penelitian 20 siswa kelas VIII MTsN 1 Medan dibagi menjadi dua kelompok yaitu kelompok eksperimen 10 orang dan kelompok kontrol 10 orang, dipilih menggunakan metode purposive sampling. Hasil Independent Sampel T-Test post test kelompok eksperimen 8,744 sedangkan hasil post test kelompok kontrol 5,425 dan adanya perbedaan signifikan antara kelompok eksperimen dengan kelompok kontrol 0,000 < 0,05 serta t hitungnya sebesar 1,598 < 2,09302 maka Ho ditolak dan Ha diterima. Maka layanan bimbingan kelompok menggunakan teknik assertive training efektif meningkatkan komunikasi interpersonal siswa. Serta skor pretest kelompok eksperimen nilai rata-rata 95,40 dan nilai posttest 102,40. Sedangkan kelompok kontrol nilai pretest rata-rata 95,90 dan nilai posttest 97,10. Maka nilai rata-rata posttest lebih tinggi di banding nilai rata-rata pretest  berarti ada perubahan signifikan.
Kata kunci: layanan bimbingan kelompok, teknik assertive training, komunikasi interpersonal siswa
Hubungan Self-Efficacy dan Kecemasan Menghadapi SNBT 2023
Authors: Lacosta Esi , Dewita Karema Sarajar
Published: July 2024

Penelitian ini bertujuan untuk mengetahui hubungan antara self-efficacy dan kecemasan dalam menghadapi SNBT 2023. Jenis penelitian ini adalah kuantitatif korelasional. Subjek dalam penelitian ini berjumlah 422 individu berusia 17-25 tahun di Indonesia yang telah mengikuti SNBT 2023 yang dipilih dengan teknik simple random sampling. Skala yang digunakan yaitu General Self-efficacy Scale oleh Bandura dengan reliabilitas 0,864 dan skala kecemasan oleh Cassady & Johnson dengan reliabilitas 0,894. Penelitian ini menggunakan teknik analisis data, yaitu analisis deskriptif, uji normalitas, uji linearitas dan analisis korelasi product moment. Hasil penelitian menunjukkan bahwa terdapat hubungan negatif antara self-efficacy dengan kecemasan dalam menghadapi SNBT 2023 dengan nilai koefisien korelasi -0,223. (p<0,05). Rata-rata partisipan dalam penelitian ini memiliki self-efficacy yang tinggi, yaitu sebanyak 306 partisipan (72,5%) dan memiliki kecemasan pada tingkat sedang, yaitu sebanyak 239 partisipan (56,6%). Individu yang memiliki self-efficacy yang tinggi akan memiliki kecemasan yang rendah ketika menghadapi SNBT 2023 dan sebaliknya.
Kata kunci: efikasi diri, kecemasan menghadapi ujian, seleksi nasional berdasarkan tes (SNBT) 2023
Factors Associated with Functioning in Older Black Adults
Authors:   , Davis Katrail
Published: July 2024

Activities of daily living can be simple tasks such as bathing, showering, toileting or as complex as managing finances, driving, and preparing meals. Independence in everyday functioning has been associated with successful aging and declines in functioning may be indicative of pathological cognitive decline. Social determinants of health, like economic status and access to health care, also play a role in everyday functioning. Understanding these factors are of particular importance for older Black adults who have had long-standing disparate access to care, education, and treatments. The current study aimed to evaluate social determinants of health, more specifically social engagement, as moderators of the association between cognition and everyday functioning. A sample of 925 older Black adults from Rush University: The Memory and Aging Project (MAP), Latino CORE Study (CORE), and Minority Adult Research Study (MARS) were used. Participants completed a battery of neuropsychological testing as well as questionnaires about their everyday functioning and social behaviors. Separate hierarchical linear regressions were utilized to determine to what extent social factors moderated the relationship between cognition and everyday functioning. Social factors were independently associated with everyday functioning and moderated the relationship between cognition and functioning. Results from the current study provide a basis for future interventions.
Creative Heritage of I. Yizhakevych in the Collections of the Central State Archives-Museum of Literature and Arts of Ukraine
Authors: Kovalchuk Inna , Kovalchuk Iryna
Published: July 2024

The paper studies the creative heritage of Ivan Yizhakevych — the People’s Artist of the Ukrainian SSR — through documents stored in various collections of the Central State Archives-Museum of Literature and Arts of Ukraine (hereinafter — the CSAMLA of Ukraine), by analyzing the descriptions of archival documents and their content, and making the attribution of the sketches, preserved in the artist’s collection. The research methodology is based on scientific methods of analysis, iconography, synthesis, description, classification, and comparison. Having analyzed the collections, including the fund 58, stored in the CSAMLA of Ukraine, several clarifications were made regarding the names of some drawings, sketches of I. Yizhakevych, literary works illustrated by the artist, and the dates of drawing for artworks marked as “undated.” Some images were identified as the sketches for some artist’s later paintings and drawings. For some reproductions of the artist’s works, stored in his fund, the year or the issue of the magazine, in which they were published, were clarified. The list of the collections, where researchers can find the information about Yizhakevych and reproductions of his artworks, was complemented. Prospects for further research are associated with study of the artworks of I. Yizhakevych in the museum collections of Ukraine, and of those published as illustrations in the fairy tales, literary works, and educational publications. It is necessary to study his monumental paintings, icons, and portraiture in order to clarify the sketches that remained unidentified. Taking into account the number of sketches, stored in the CSAMLA of Ukraine, which were not identified or correlated with completed artworks of the artist, it is clear that his great creative heritage requires further research. It is essential to catalogue the drawings and paintings created by I. Yizhakevych.
The Ukrainian Artistic Community in the United States in the late 1940s to the 1960s: A Socio-Cultural Portrait
Authors: Pidsukha Oksana
Published: July 2024

The article analyzes the socio-cultural life of the Ukrainian artistic community—visual artists—who actively worked or began their professional activities in the United States after the World War II (from the end of the 1940s until the 1960s). The main centers of their settlement in the United States are identified, and their belonging to different waves of Ukrainian emigration and generations is classified. The paper also identifies the educational level of the community members, some art schools, where Ukrainian artists studied in the United States, and traces the process of professional adaptation and/or their professional realization in emigration, as well as their involvement in the cultural activities of the local Ukrainian diaspora. The aim of the paper is to identify the main features of the socio-cultural portrait of the Ukrainian artistic community in the United States during this period. The problem of the socio-cultural integration of artists outside their homeland is actualized in the context of a new wave of mass emigration from Ukraine against the backdrop of war and globalization. The article introduces little-known materials on the issue; systematizes and summarizes the collective experience of Ukrainian artists in entering the American socio-cultural environment; highlights some characteristics of the community. It is stated that the majority of Ukrainian artists of the older generation who arrived in the United States after World War II, having passed the initial difficult stage of social adaptation, integrated into American society. A large group of fine artists combined their creativity with stable work in areas close to their main specialty. At the same time, Ukrainian artists did not assimilate: they became active in the Ukrainian diaspora, created Ukrainian centers, and/or participated in the activities of numerous Ukrainian cultural institutions, including the U.A.A.A (Ukrainian Artist’s Association in U.S.A). The younger generation of Ukrainian emigrant artists, on the other hand, demonstrated a diversity of socio-cultural activities from the very beginning.
Commemorative Practices During the War: Bohdan Mazur’s project Memory of Civilian Victims
Authors: Herasymchuk Volodymyr
Published: July 2024

The article explores actual issues related to the memorial aspect of commemorating the fallen civilians of Ukraine as a result of russian aggression, focusing on the creative aspects of the commemorative issue in the space of urban architecture and forms of social communication aimed at creating such memorial zones as a part of the collective memory and commemorative policy of the state as a whole. The aim of the paper is to analyze creative practices and socio-cultural (institutional) interactions that strive to implement memorial cultural policy during the war. The subject field of the article is the practical implementation of the idea of the memorial architectural project In Memory of Civilian Victims by Bohdan Mazur, a famous Ukrainian sculptor. It is on the example of the implementation of B. Mazur’s memorial project that the author highlights contradictory approaches and views, problem areas of this project’s implementation: from the forms of memorialization of tragic events to the ways of communicating with authorities, opinion leaders, and professional experts on this issue in the context of wartime.
Aesthetics of Pure Negativity. Part Two: The Subjectivity in the Shagreen Skin
Authors: Shkepu Mariia
Published: July 2024

The phenomenon of the aesthetics of pure negativity arose as a result of the loss or deliberate ignoring by humans of the postmodern objective basis and the defining contradictions of the historical process. “Desertion from history” (Ortega y Gasset), through the artificial formation of a time-space of subjectivity, provoked a particular situation of regressive phenomenological semantics with equally regressive aesthetics. The narrowing of life’s meanings as “diminishment of man” (C. Noica) led to the degradation of the subject of history and the limitation of his existential aspirations by societal functionality for the sake of vitality per se. “Non-correspondence to one’s own concept” (Hegel) among all social strata in the context of their place and significance in the historical process, the regression of historical reason, and the degradation of humanity’s theoretical self-awareness generated the effect of shagreen skin of subjectivity. This last is accompanied by a mismatch of simplified thinking to the highly complex contradictions of objective reality, simulations of subjective realities acting as fragmentary abstractions, artificial stagnations of mediations granted autonomous status, and the impossibility of realizing subjective desires in a disintegrating world. Ultimately, it results in essential non-realizability. This deregulation of subjectivity is “rooted” in the deregulation of both its internal and external forms and its no less deregulated relationship with the equally deregulated historical reality. This reversed system of deregulated subsystems is accompanied not only by the chaos of mismatches between subjectivities and objective reality—due to irrationality and absurdity, it moves towards semantic emptiness and real exhaustion. This highlights the necessity to return to understanding the law of the fundamental basis of history and the reproduction of its essential contradiction in the mode of resolving the universal-historical contradictions of the present.
Improving Cancer Therapy: Design, Synthesis, and Evaluation of Carboplatin-Based Nanoliposomes against Breast Cancer Cell Lines
Authors: Hadisadegh Seyedeh Negin , Ghanbarikondori Parizad , Sedighi Armin , Afyouni Iman , Javadpour Nikoo , Ebadi Mehrnoosh
Published: July 2024

Objective: Cancer poses a significant challenge to modern medicine, with breast carcinoma being one of the most prevalent forms of the disease. Carboplatin is a commonly used chemotherapy drug for treating breast cancer, but its efficacy can be limited due to its poor water solubility and associated side effects. This study intended to enhance the therapeutic potency of carboplatin by encapsulating it within liposomal nanocarriers.
Methods: We fabricated nanoscale liposomes loaded with carboplatin via a technique called reverse phase evaporation, and examined their physical attributes. We also studied the toxicity of these nanoliposomes on MDA-MB 231 breast cancer cells.
Results: Our findings indicated that the liposomal nanoparticles possessed a negative zeta potential of -18.2 mV and an average size of 278 nm. The drug loading level was 2.2%, while the efficiency of drug encapsulation reached 58.5%. Of note, the cytotoxicity of carboplatin in its nanoliposomal form was markedly more potent against the MDA-MB 231 breast cancer cell line than the free drug (p-value less than 0.05).
Conclusion: Our findings suggest that carboplatin-loaded liposomal nanocarriers could potentially serve as an advanced chemotherapeutic approach for the treatment of breast cancer, offering enhanced efficacy and reduced side effects compared to conventional carboplatin therapy. Further research is warranted to explore this novel delivery system’s benefits fully.
A Real World Analysis of Safety and Efficacy of Nilotinib when Used as First Line and Beyond: Retrospective Single Centre Study Representing Largest Cohort of Indian Patients Treated with Nilotinib
Authors: Kumar Sujeet , Singh Anil , Singh Neha , Faizi Akbar Inam , Mishra Bal Krishna , Gupta Avinash , Yadav Anil Kumar
Published: July 2024

Background: Efficacy and toxicity of TKIs may vary depending on the ethnic background or genetic factors; hence it is important to gather data from individual populations pertaining to each drug. The pivotal registration trial had not enrolled any patient from India and there are very limited published studies on its efficacy as well as safety from Indian patients with CML.
Methods: Hospital Electronic Medical Record was screened for adult (age > 18 years) CML patients registered (n = 1290) at our hospital from 1st May 2018 to 31st December 2022. CML-CP or CML-AP patients, those who have received Nilotinib as 1st line (n = 40) or 2nd line (n = 66) or 3rd line TKI (n = 20) for at least 90 days (3 months) and have at least one RQ PCR BCR: ABL value post Nilotinib initiation, were enrolled in this study (n = 126).
Results: Eighty (74.1%) patients achieved BCR/ABL of ≤ 1% at 12 months. MMR and MR4 at 12 months was seen in 44 (40.7%) and 19 (17.6%) patients respectively. The most common haematological toxicity was thrombocytopenia of any grade seen in 54 (42.8%) patients.
Conclusion: Our study demonstrates that treatment with Nilotinib was well-tolerated in Indian patients and was effective in achieving molecular remission rates in 1st, 2nd or 3rd line therapy in the real-world setting. Safety and efficacy were in line with published western or Asian studies.
Acute Toxicities and Treatment tolerance of Neoadjuvant Chemoradiation in Rectal Cancer: A Tertiary Cancer Centre Analysis
Authors: Penumur Manasa , Chanayil Goutham Raj , Goswami Smriti , Goswami Bibhash Chandra , Paul Moumita , Bora Ghritashee
Published: July 2024

Aims: To assess acute toxicities and treatment tolerance in patients of carcinoma rectum of NACTRT at a tertiary care centre of North-East India.
Materials and Methods: A total of 50 patients of histologically proven Rectal Adenocarcinoma recruited from July 2022 to May 2023 were included in the study. All patients were planned for either NACTRT (n=44) or Total Neoadjuvant Treatment (TNT)(n=6) followed by assessment for surgery. A total dose of 50.4Gy/28# was planned with concurrent oral chemotherapy with T. Capecitabine at a dose of 825 mg/m2 twice daily. Acute toxicities were assessed using RTOG grading criteria. Patients’ toxicity assessment was done weekly with clinical examination and laboratory parameters. Patients were also assessed at the end of RT and 4 weeks post completion of NACTRT.
Results: All patients could complete the prescribed dose of EBRT (50.4Gy/28#) over a period of 6 weeks. On toxicity assessment, Grade-I dermatitis was seen in 14 patients (56%), Grade-II in 14 patients (54%), Grade-III in 2 patients (7.6%). In lower gastrointestinal toxicities, Grade-I diarrhea occurred for 4 patients (50%), Grade-II diarrhea in 3 patients (37.5%) and Grade III diarrhea in 1 patient (7.6%). Grade-I genitourinary toxicity was observed in 4 patients (8%). Hematological toxicities were seen for 40 patients of which Grade-I, Grade-II, Grade-III Anemia were seen in 10 (38.4%), 14 (54%), 2 (7.6%) patients respectively. Grade 1 and Grade 2 leucopenia were seen in 4 (57%) and 3 (43%) patients respectively. Deranged LFT was seen for 7 patients (15%), out of whom dose modifications were required for 5 patients (10%). Treatment was put on hold for 3 patients (6%) for 3 days due to grade 3 toxicities.
Conclusion: NACTRT in rectal cancer patients was associated with acceptable toxicities and treatment tolerance. Modern EBRT techniques like IMRT should be evaluated in an effort to further reduce the radiation related toxicities.
Molecular Epidemiology of Human Papilloma Virus (HPV) in Women’s Cervical Samples from Tehran, Iran
Authors: Kashefi Fatemeh , Alizadeh Mitra , Sadat Kalaki Niloufar , Ejlalidiz Mahsa , Yazdani Shaghayegh , Shayestehpour Mohammad , Farsi Mahsa , Emtiazi Nikoo , Hemmasi Gholamreza , Karbalaie Niya Mohammad Hadi
Published: July 2024

Background: Cervical cancer (CC) is the second-leading cause of cancer death among women. In this cancer, more than any other type of malignancy, the effects of prevention, early diagnosis, and timely treatment on reducing the death rate are evident. Hence the aim of this study was to Investigating the prevalence of human papilloma virus different genotypes in women’s cervical tissue samples.
Methods: In this cross-sectional study, 1045 samples obtained from referred patients were selected for periodic cervical examinations. Then, DNA extraction from cytology liquid brush was done in accordance with the standard method. The presence of HPV was determined by PCR. By using pyrosequencing method and then BLAST online search, HPV genotypes were identified.
Results: of 1045 patients, 159 (15%) had HPV infection in which 50.3% were LSIL by frequent HPV types 6, 18, 16, 11; 19.4% were HSIL by frequent HPV types 16, 18, and 30.1% were ASCUS by frequent HPV types 6, 11, respectively. The age group, 30–40 years had the highest prevalence of HPV infection (p-value = 0.6). 21.4% people diagnosed by mix genotype HPV infection. significant value identified by the pathological patterns and multiple types infections (p-value=0.007), HPV-16 infection and younger age (p-value=0.02).
Conclusion: our study showed 15% HPV infection identified in studied samples and the most HPV prevalent types were 6, 18, 11, 16, respectively. HPV-16 is common in younger ages. HPV vaccination and regular screening programs are major prevention measures.
Assessment of the HER2 Equivocal Cases in Breast Cancer Following Laterality
Authors: Gadhia Pankaj , Joshi Niharika , Vaniawala Salil
Published: July 2024

Background: Breast cancer is a leading cancer among Indian women. Approximately 15-30% of cases are linked to HER2 gene overexpression, impacting survival. Despite of the advancements in HER2-targeted therapies equivocal HER2 status poses diagnostic challenges and is comparatively less studied. Breast cancer also displays a peculiar laterality, with a consistent left-sided predominance, yet the underlying factors remain unclear.
Methods: A retrospective analysis of 488 breast cancer cases with equivocal HER2 status confirmed by Fluorescent In-Situ Hybridization (FISH) was conducted. Data included age, hormone receptor status, molecular subtypes, grade, Ki67 status, and FISH scores. Statistical analysis was performed using the R language, and laterality ratios were calculated.
Results: Left-sided breast cancer prevalence was 64.95%, with a laterality ratio of 1.85. Age-related variations and significant laterality preferences were observed in Grade III tumors. Molecular subtypes, particularly Triple Negative, exhibited distinct laterality patterns. Equivocal cases displayed varied FISH scores, emphasizing molecular heterogeneity.
Conclusions: This study comprehensively analysis of HER2-equivocal breast cancer cases, shedding light on laterality patterns and their associations. The observed left-sided predominance suggests potential underlying factors, including age, tumor grade, and molecular subtypes. Understanding these sophistications is crucial for personalized treatment strategies and warrants further investigation into the complex interplay of clinicopathological factors influencing breast cancer laterality.
Biomarker Panel for Early Detection in Uterine Cancer: A Review
Authors: Priya N. Deepthi , Nanda Kumar K. V. , Charani M. Siva , Bindu D. , Reddy K. Likhitha , Gowthami Y.
Published: July 2024

Uterine cancer is the numerous prevalent cancers of the female reproductive tract in industrialized as well as developing countries and its probability is arising annually. There is a total of approximated 90,000 mortality and 382,000 instances newly cases treated annually globally. The desire to create and define biological markers for the initial stages detection and therapy of uterine cancer is growing. We analyze the current state of biomarker utilization for early detection, including their sensitivity and specificity, paving the way for timely interventions. Several biomarkers, including P53, K-RAS, CA-125, HER2/neu, HE4, PTEN, MSI, ARID1A,Ki-67, microRNAs, DNA aneuploidy, estrogen and progesterone receptors are used for early detection, treatment, and prevention of uterine cancer. Oncogene biomarkers such as VEGF, Hypoxia-inducible factor-1α (HIF-1α), and PI3K-AKT- mTOR signalling pathways plays a crucial roles in cancer progression, offering promising targets for therapeutic intervention and prognostic assessment. Prognostic and emerging biomarkers L1CAM, MMR proteins, CTCs shed form primary tumors into the bloodstream, offer insights into tumour dissemination and treatment response. In conclusion, early detection through all biomarkers holds great promise for early diagnosis and treatment advancements, as well as providing hope for better results and a higher standard of living for individuals in future generations. This review aims to provide a holistic understanding of uterine cancer biology and its clinical implications.
Factors Militating Against Family Caregivers on Cancer Patients Health in Selected Teaching Hospitals in Ogbomoso Area, Oyo State, Nigeria
Authors: Ofuoma Amoo Patience , Ncama Busisiwe
Published: July 2024

Introduction: Cancer is gradually becoming a chronic disease, which brings important needs and difficulties to both patients and caregivers.
Objective: The study examines factors militating against family caregivers on cancer patients health in selected teaching hospitals in Ogbomoso area, Oyo State, Nigeria.
Materials and Methods: Both questionnaire and interviewed techniques were used for data collection from 120 respondents chosen through stratified sampling techniques. In analyzing the data, logit regression model was employed in addition to conventional descriptive statistics such as tables, frequency distribution and percentages.
Results: The result of regression model has coefficient of five (5) variables that were statistically significant at 1%, and 5% probability levels. The results revealed that variables with positive signs indicate that the chances of factors militating against family caregivers on cancer patients health increase with education (2.15), social support (2.76), communication, (2.67), and financial support (4.92) whereas, variables with negative sign indicates that the chances of factor militating against family caregivers on cancer patients health decreases with socio-cultural beliefs (-2.64).
Conclusion: It identified that factors militating against family caregivers on cancer patients health strongly influenced by gender, age, education, marital status and religion. Hence, recommendation was made that regular systemic assessment of effects of caregiving and shared care responsibility among family members to provide a respite for a particular caregiver.
Analisis Faktor Yang Berhubungan dengan Pemanfaatan Layanan poliklinik Pasien Rawat Jalan RSUD Brigjend. H. Hasan Basry Kandangan
Authors: Nizwar Muhammad , Arifin Syamsul , Panghiyangani Roselina , Husaini Husaini , Nugroho Adi
Published: July 2024

Tingkat kunjungan pasien merupakan sebuah indikator kinerja untuk Rumah Sakit yang berbanding lurus dengan pendapatan. Pendapatan Rumah Sakit Umum Daerah (RSUD) Brigjend. H. Hasan Basry Kandangan memberikan kontribusi sebesar 11% terhadap pendapatan asli daerah pada tahun 2022 sehingga apabila  terjadi penurunan pendapatan RSUD) Brigjend. H. Hasan Basry Kandangan maka mengakibatkan pendapatan daerah turut mengalami penurunan. Mengetahui hubungan antara usia, jenis kelamin, dan fasilitas dengan pemanfatan pelayanan pada poliklinik rawat jalan. Studi ini bersifat observasional analitik dan menggunakan pendekatan cross-sectional dengan rumus slovin 92 sampel diambil dengan teknik purposive sampling. Penelitian menggunakan kuesioner. Variabel terikat: pemanfatan pelayanan pada poliklinik rawat jalan. Variabel bebas:Usia, jenis kelamin, dan fasilitas. Analisis bivariat menggunakan chi-square dan multivariat menggunakan regresi logistik berganda. Hasil penelitian menunjukkan terdapat hubungan antara usia(p=0,001), jenis kelamin(p=0,003), dan fasilitas(p=000) dengan pemanfatan pelayanan. Variabel fasilitas paling berhubungan dengan pemanfatan pelayanan pada poliklinik rawat jalan RSUD Brigjend. H Hasan Basry Kandangan. Terdapat hubungan antara usia, jenis kelamin, dan fasilitas dengan pemanfaatan layanan. Variabel yang paling berhubungan dengan pemanfaatan layanan poliklinik pasien rawat jalan RSUD Brigjend. H. Hasan Basry Kandangan adalah fasilitas.
Efektivitas Tripikon Terhadap Kualitas Air Daerah Bantaran Sungai
Authors: Agustina Norsita , Indah Meilya Farika , Chandra Chandra , Asrinawaty Asrinawaty , Fauzan Akhmad , Rahman Eddy
Published: July 2024

Tangki septik dan resapan merupakan bagian dari rangkaian pengolahan limbah tinja yang harus dipenuhi agar terpenuhinya syarat kualitas air pada lingkungan di sekitar. Pada penelitian ini adalah menganalisis efektifitas tripikon ditinjau dari parameter BOD dan MPN Coliform. Penelitian survey yang bersifat deskriptif yang disertai dengan pemeriksaan laboratorium untuk manganalisis kualitas air dengan parameter BOD dan MPN Coliform pada air limbah di tripikon sebanyak  5 titik sampel. Variabel bebas dalam penelitian ini yaitu tripikon sedangkan variabel terikatnya adalah kadar BOD dan MPN Coliform. Kadar BOD dan MPN Coliform diperiksa di BARISTAND Banjarbaru. Hasil yang didapat adalah bahwa kadar BOD (30 mg/L) memenuhi kadar maksimum yang diperkenankan bagi limbah domestik bagi rumah tangga sesuai Peraturan Menteri Lingkungan Hidup dan Kehutanan no 68 tahun 2016. Sedangkan Hasil pengukuran MPN Coliform pada outlet tangki yaitu 2310 mg/l jumlah per 100 ml air limbah pada saat pengambilan sampel pagi hari dan sore menjelang malam hari yaitu 2650 mg/l. Penelitian ini disimpulkan bahwa penggunaan tripikon memiliki efektivitas dalam penurunan kadar BOD dan MPN. Coliform terhadap kualitas air pada bantaran sungai
Servicios locales de educación pública: principales tensiones y desafíos para los directores escolares
Authors: Leiva-Guerrero María Verónica , Benavides-Meneses Matías
Published: July 2024

La Ley 21.040 de 2017 crea el Sistema de Educación Pública en Chile, conformado por el Ministerio de Educación, la Dirección de Educación Pública y los Servicios Locales de Educación Pública. Estos últimos reemplazan la gestión y responsabilidad que tenían a cargo las municipalidades y los establecimientos educacionales, constituyendo organismos públicos especializados en la gestión educacional, descentralizados funcional y territorialmente, con planta propia de personal profesionalizado, personalidad jurídica y patrimonio propio. Como objetivo se plantea comprender cómo los directores de centros escolares han vivido y gestionado la desmunicipalización y traspaso a los Servicios Locales, qué tensiones y desafíos abordan. Para ello, se propone un estudio mixto cuali-cuanti, con diseño secuencial explicatorio, aplicación de encuestas y entrevistas a directores/as de establecimientos pertenecientes a los Servicios Locales. Los resultados evidencian que los/as directores/as son consistentes en manifestar como principal tensión la gestión administrativa, referida a la disposición oportuna de recursos (63%), el involucramiento de los Servicios Locales con las escuelas (58%), los planteamientos y regulaciones de la convivencia escolar (42%) y el monitoreo de la enseñanza y el aprendizaje (41%). Se concluye como desafíos la instalación de capacidades y condiciones especializadas en las escuelas y en los SLEP para avanzar hacia una real calidad de la educación chilena.
Sprytne, jeśli uczciwe. Ocena legalnych i nielegalnych zachowań podatkowych pracowników i przedsiębiorców
Authors: Kołodziej Sabina
Published: July 2024

Cel: Dążenie do zminimalizowania wysokości płaconych podatków jest interpretowane jako troska o interes własny, która stanowi jeden z podstawowych motywów działania i postrzegania społecznego. Skorzystanie z możliwości uchylenia się od podatków natomiast może wiązać się ze zniekształcaniem oceny moralnej takiego zachowania, aby utrzymać pozytywny obraz samego siebie. Celem przedstawionego badania była analiza społecznych ocen unikania i uchylania się od podatków uwzględniających perspektywę osoby dokonującej danej oceny. Z uwagi na różnice w zakresie dostępnych dla pracowników i przedsiębiorców legalnych i nielegalnych metod obniżania wysokości płaconych podatków w badaniu uwzględniono scenariusze odwołujące się do tych dwóch grup podatników.
Metoda: Badanie zostało przeprowadzone w metodologii CAWI na próbie polskich podatników (N = 223). Posłużono się autorską ankietą zawierającą krótki opis czterech sytuacji podatkowych różniących się legalnością danego działania oraz charakterystyką osoby, która je podejmowała. Zadaniem respondenta była ocena przedstawionych zachowań na skali dyferencjału semantycznego: sprytne – niesprytne.
Wyniki: Respondenci przypisywali więcej sprytu legalnemu niż nielegalnemu obniżaniu podatków. W przypadku oceny uchylania się od podatków pozostawała ona powiązana z faktem, czy opisany podatnik był pracownikiem, czy przedsiębiorcą, natomiast w odniesieniu do unikania podatków zależała ona także od formy zatrudnienia respondenta. Bardziej pozytywna ocena działań własnej grupy zawodowej dotyczyła jedynie unikania podatków przez przedsiębiorców.
Konkluzja: Legalne i nielegalne metody obniżania podatków są rozróżniane społecznie, zaś bardziej pozytywna ocena tych działań zależy od ich zgodności z prawem. Wyniki badania nie pozwalają na sformułowanie twierdzenia o występowaniu egocentrycznego zniekształcenia ocen w odniesieniu do analizowanych zachowań podatkowych pracowników i przedsiębiorców.
Spinal extramedullary hematopoiesis mimicking an epidural tumor in a patient with high-risk polycythemia vera: illustrative case
Authors: Hawkins Ashlee N , Breton Jeffrey M , Bhatnagar Akrita , Paudel Nitika , Voyadzis Jean-Marc
Published: July 2024

BACKGROUND

Here the authors present the case of a 43-year-old male with a history of T-cell lymphoma, which was treated with azacitidine plus cyclophosphamide, doxorubicin, vincristine, and prednisone and autologous hematopoietic cell transplant, and high-risk polycythemia vera (PCV) presenting with severe lower-back pain radiating to the bilateral legs with associated lower-extremity weakness and splenomegaly.

OBSERVATIONS

T2-weighted magnetic resonance imaging revealed multilevel epidural lesions involving T1–10 and S1–2. Because of severe spinal canal stenosis, the patient underwent surgical decompression of T5–7, with immediate postoperative alleviation of the lower-extremity pain and complete resolution of the lower-leg weakness. Biopsy results revealed extramedullary hematopoiesis (EMH) mimicking a spinal epidural tumor. EMH is radiosensitive and displays a rapid response to low dosages, so the patient was further treated with palliative radiation therapy for residual tumors and symptom alleviation, as well as hydroxyurea and corticosteroids as indicated for cytoreduction.

LESSONS

EMH associated with PCV or myeloproliferative conditions occurring within the spine is a rare phenomenon without a standard treatment approach.

https://thejns.org/doi/10.3171/CASE23659