bluuebunny/crossref_metadata_2025 huggingface dataset:
Covid-19 Salgını Sürecinde Öğretmenlerin Acil Uzaktan Eğitimle İlgili Düşünce ve Deneyimleri
Authors: Çetin Gülcan , Çakır Özge
Published: July 2024

Çalışmanın amacı, Covid-19 salgını sürecinde öğretmenlerin acil uzaktan eğitimle ilgili düşünce ve deneyimlerini belirlemektir. Araştırma, nitel araştırma yöntemlerinden olgubilim desenine göre yürütülmüştür. Çalışma grubunu, 2020-2021 eğitim-öğretim yılında İzmir’de bir Anadolu lisesinde görev yapan 18 öğretmen oluşturmaktadır. Veriler, yarı-yapılandırılmış görüşme formu kullanılarak toplanmıştır. Öğretmenlerle birebir görüşmeler Zoom uygulamasında gerçekleştirilmiştir. Veri analizinde, içerik analizi yöntemi kullanılmıştır. Çalışma sonuçlarına göre, öğretmenlerin düz anlatım, soru-cevap ve ev ödevi vererek sunuş yoluyla öğretim yöntemini kullandıkları belirlenmiştir. Öğretmenlerin ders öncesi, ders sırası ve ders sonrasında çeşitli videolar, testler ve konu anlatım sunularını paylaştıkları belirlenmiştir. Öğretmenlerin çoğu paylaştıkları içerikleri yeterli bulmuştur. Öğretmenlerin bir kısmı ise, EBA’da sınırlı sayıda test ve etkinlik bulunması ve bunların da bilişsel olarak üst düzeyde olmaması gibi nedenlerle içerikleri yetersiz bulmuşlardır. Öğrenmelerin bazıları öğrencilerin öğrenmelerini değerlendirebildiklerini, yarısı kısmen değerlendirebildiklerini ve çok az bir kısmı ise değerlendiremediklerini belirtmişlerdir. Öğretmenler ölçme ve değerlendirmeyi; soru-cevap, ödev ve Google formlar aracılığıyla yapmışlardır. Öğretmenler eğitim-öğretimin gerçekleşmesi, derste materyal kullanılması, zaman tasarrufu, sağlığın korunması bakımından acil uzaktan eğitimin olumlu yönlerine dikkat çekerken, bu süreçte eğitim-öğretimde yaşanan zorluklar, iletişim eksikliği, öğrenci ve öğretmen motivasyonu, teknolojik sorunlar, sağlığın korunmasına ilişkin riskler açısından ise acil uzaktan eğitimin olumsuz yönlerine değinmişlerdir. Öğretmenler; teknolojik alt yapının sağlanması ve öğrenci kameralarının açılması konusunda önerilerde bulunmuşlardır. Öğretmenler MEB’in öğrencilere online sınav yapmasını ve okulun öğrencilerle çevrimiçi sosyal etkinlikler gerçekleştirilmesini de beklemektedirler.
Dropout and Graduation in Higher Education: CHAID Analysis
Authors: Hark Söylemez Nesrin
Published: July 2024

This study aims to investigate the socioeconomic variables and their order of importance that have a significant effect on the dropout and graduation of higher education students. Relational survey model was used in the study. In the study, the "Students Dropout and Academic Success Dataset," was utilized. The dataset, created by the Polytechnic Institute of Portalegre, consists of 4424 records. CHAID decision tree algorithm was used to analyze the data. With this method, the independent variables that demonstrate the maximum variation in the dependent variable have been identified hierarchically. It is found that, 49.93% of the students are “graduate”, 32.12% are “dropout”, and 17.948% are “enrolled”. Obtained findings show that the graduation rates of the students are not at the desired level. “Tuition fees up to date” was found as the best variable that explains the students’ school completion. 86.55% of students with not up to date tuition fees were found as dropout and 55.95% of students with up-to-date tuition fees were found as graduate. “Scholarship holder” was found as the variable that best explains the clusters formed by variable “tuition fees up to date”. 89.00% of the students that don’t have their tuition fees up to date and don’t hold a scholarship dropout the school, while 78.44% of students that have their tuition fees up to date and holding a scholarship are graduate. Building on the results obtained from the study, several suggestions were proposed for coping with dropout problem and further guiding research on dropout.
Immunohistochemistry for brain sections v1
Authors: Unda Santiago , Marongiu Roberta , G. Kaplitt Michael
Published: July 2024

Protocol for processing 30um mouse brain sections for immunolabeling.
Self-Healing of Complex Hardware and Software Systems
Authors: Kostiukhin K. A. ,   Federal State Institution ",   Scientific Research Institute for System Analysis of the Russian Academy of Sciences",   , Moscow, 117218, Russian Federation
Published: July 2024

The article discusses various approaches to the organization of self-healing of complex systems. Modern technologies for the development of self-stabilizing systems, including reflection, graceful degradation and rejuvenation of system components, are analyzed. The role of artificial intelligence in self-treatment and self-healing of systems is considered. Modern hardware and software systems are becoming increasingly complex, which, in turn, increases the likelihood of events that may prevent the system from functioning normally. This can lead to huge losses for organizations that are becoming increasingly dependent on information systems. Various methods are traditionally used to minimize the risks associated with errors, attacks and failures. For example, an organization may decide to move to another resource in an alternative physical location (cloud), use data replication, backup servers, and so on. But as the system becomes more complex (more components, more external integrations), the implementation of some ways to ensure reliability and fault tolerance can be very expensive in terms of the resources needed for this. In this paper, we consider an integrated approach that allows an information system to fulfill its mission, called self-healing of systems.
Knowledge Graph Formation Using LLM for Disease Treatment in Decision Support Systems
Authors: Gribova V. V. ,   , Institute of Automation and Control Processes, Far Eastern Branch of Russian, Academy of Sciences, Vladivostok, 690041, Russian Federation, Perevolotsky V. S. ,   Far Eastern Federal University, Vladivostok, 690922, Russian Federation,   Far Eastern Federal University, Vladivostok, 690922, Russian Federation
Published: July 2024

The article presents an advanced method for creating knowledge graphs, applicable in medical decision support systems. It focuses on adapting the method to various clinical guidelines, making it particularly valuable in the medi¬cal field. The developed universal ontological pattern allows for the formation of knowledge bases for a wide range of diseases, making the process flexible and scalable without the need for specific programming. This approach significantly reduces the labor intensity of creating medical support systems and facilitates their integration and adaptation to various clinical conditions and requirements. The practical significance of the method was confirmed in the management systems for the therapy of various diseases, including allergic rhinitis, underscoring its universality and applicability in the current medical context. The effectiveness of the proposed approach opens new perspectives for the development and improvement of medical information systems, contributing to the improvement of patient care and treatment quality. Thus, the article makes a significant contribution to the advancement of information technology in medicine, offering a solution that can be adapted for a wide range of medical applications and research.
Redefining Archival Reference: Relationship-based Reference
Authors: Duff Wendy , Ho Jessica , Sato Christa , Aton Henria , Deziak Peter , Regehr Cheryl
Published: July 2024

This article argues that archival access systems require a new archival ecosystem (physical infrastructure, access tools, e.g., catalogs, findings aids, indexes, rules policies procedures, and institutional supports) and a broader conceptual framing. Based on the findings from sixteen interviews with archivists, this article proposes a multifaceted, relationship-based access framework. The framework focuses on supporting users studying difficult histories or members of oppressed communities in a physical archives but also highlights elements that all users might appreciate.
(Re)Appraising Our Archival Identity: Demystifying the Process and Changing the Dialogue about Promotion and Tenure for Academic Archivists
Authors: Scott Elizabeth M. , Moyer Heidi Abbey , Hankins Rebecca , Walton Rachel
Published: July 2024

Within the archival discourse, there has been minimal research or dialogue about the processes and experiences for academic archivists associated with earning promotion and tenure. Recent reviews of the literature suggest that this topic remains largely unexplored in archivists’ professional and scholarly conversations, despite its pivotal influence on job security, advancement, and identity for those working in academia. This article intends to explain and demystify the procedures and best practices for navigating promotion and tenure by providing guidance and insight for archivists throughout their careers. Furthermore, the authors aim to expose the culture of silence surrounding the promotion and tenure process for archivists while also underscoring the power dynamics involved in evaluation activities. This research explores how these actions have impacted historically underserved and marginalized groups and encourages our archives community to counter these forces through professional awareness and by embracing and applying diversity, equity, inclusion, belonging, and accessibility principles. The authors advocate for a framework that solidifies, clarifies, and encourages increased transparency in the promotion and tenure process and offer profession-wide recommendations to help make this change. Finally, this article serves as a call to action for rethinking our professional identity by championing our collective contributions to the higher education landscape and distinguishing the specialized expertise of archivists from that of our librarian colleagues in the academy.
“Taking Our Own Measure”: Archival Engagement and Storytelling
Authors: Meehan Jennifer
Published: July 2024

As archivists are increasingly called upon to measure and demonstrate our value, it is vital to consider not only what we are measuring and why, but also what is beyond measure (what can't be captured by data and metrics) and how we communicate value beyond what can necessarily be measured. In exploring these questions, the author offers some provisional ideas for reframing the discourse and practice around archival metrics and assessment, and for opening space to “take our own measure” more fully and demonstrate the true value of archives. Looking beyond metrics per se, the author first traces a broader notion of archival engagement as an outcome-oriented and people-centered conceptual frame for contemplating and assessing archival value(s) beyond measure, and then considers the role of storytelling in communicating value and ways for framing our stories in terms of archival engagement to convey meaning and impact.
Alzheimer’s disease: risk factors, cellular and molecular basis of pathogenesis, analysis of pathogenetic mechanisms in comparison with amyotrophic lateral sclerosis
Authors: Akhmadieva Liaisan A. , Nagiev Kerim K. , Zefirov Andrey L , Mukhamedyarov Marat A.
Published: July 2024

Alzheimer’s disease is a neurodegenerative disease characterized by progressive neurocognitive dysfunction. Today, studying the pathogenesis of this disease remains an urgent problem. The review describes the pathogenetic basis of Alzheimer’s disease, including not only extracellular deposition of amyloid plaques and intracellular hyperphosphorylation of tau protein with subsequent formation of neurofibrillary tangles, but also mitochondrial dysfunction, impaired autophagy, neuroinflammation, etc. Data are presented on the effect of hyperphosphorylated tau protein on the breakdown and enhancement of β-amyloid peptide synthesis. Oligomerized tau protein causes proteasomal dysfunction and oxidative stress. Mitochondrial dysfunction is closely related to oxidative stress, which can be both a cause and a consequence. Autophagy, namely mitophagy, in turn, also plays an important role in the development of mitochondrial dysfunction. It can be argued that neuroinflammation is associated with all of the listed links in pathogenesis. This review also examines the influence of intestinal dysbiosis on the development of the disease. The complex mutual influence of pathogenetic mechanisms forms a multicomponent network of pathological processes. Understanding the Alzheimer’s disease pathogenesis is necessary in the search for methods for correcting impaired functioning mechanisms of the nervous system, which will help develop effective methods for treating this disease. In addition, to better understand the mechanisms of Alzheimer’s disease development, it is necessary to search for common pathogenetic factors with other neurodegenerative diseases.
Gender and age clinical characteristics of patients with acute coronary syndrome
Authors: Boulashova Olga V. , Mukhitova Elza I. , Khazova Elena V.
Published: July 2024

Cardiovascular diseases remain a common cause of morbidity and mortality in populations around the world, varying in incidence by age and gender. Every year, more than 7 million people around the world are diagnosed with acute coronary syndrome, which may be the first clinical manifestation of coronary heart disease. In the ranking of mortality causes in the Russian Federation, diseases of the circulatory system occupy a leading place. The purpose of the review was to analyze the clinical characteristics and spectrum of coronary lesions of patients with acute coronary syndrome depending on age and gender. Thus, according to the results of coronary angiography, young patients with myocardial infarction were rarely accompanied by multivessel or ostial lesions of the coronary arteries, in contrast to the elderly patients. It was revealed that multivessel lesions of the coronary arteries more often characterize males, and singlevessel lesions more often characterize females. It is obvious that the prognosis of patients with acute coronary syndrome will largely depend not only on age and gender, but also on the outcome of the syndrome, the quality and scope of diagnostic and treatment procedures. This is especially important since most patients under 60 years of age are exposed to some form of systematic work load in their field of activity. The influence of polypathy, characteristic of modern cardiac patients, can be expressed to varying degrees depending on the gender and age of the patient with acute coronary syndrome. The article presents data on the short-term and long-term prognosis of patients with acute coronary syndrome, taking into account gender and age periods, including depending on the tactics of their management. Determining the clinical characteristics of patients of different ages allows to take them into account for selecting effective and safe therapy, preventing wave-like atherosclerosis as the main cause of coronary heart disease, thereby improving prognosis and survival.
Pengaruh Konseling Modification Mindful Self Compassion (MMSC) Terhadap Self Compassion Siswa Madrasah Aliyah
Authors: Haryani Ninik , IM Hambali  , Arbin Janu Setiyowati
Published: July 2024

Abstract: Low self-compassion of students will affect the completion of their developmental tasks and have a negative impact on aspects of their lives. This has become an urgency for research to be carried out which aims to determine the effectiveness of Modification Mindful Self-Compassion (MMSC) group counseling to increase the self-compassion of MA students. This research method is a quasi-experiment with a nonequivalent control group design that has an experimental group and a control group. The research subjects were 5 students who were determined through non-probability sampling techniques with purposive sampling with certain criteria specifically students who were class X at MAN 4 Kampar with low self-compassion scale results. The research procedures are pre-group counseling, intervention, and post-group counseling. Data were collected using a questionnaire with a self-compassion scale which was conducted as a pretest before the intervention and a posttest after the intervention. After the data is obtained, the data is then processed using data analysis techniques is descriptive data analysis and the Wilcoxon test. The research results show that Modification Mindful Self Compassion (MMSC) Group Counseling is effective in increasing the self compassion of MA students.
Abstrak: Self compassion peserta didik yang rendah akan mempengaruhi penyelesaian tugas perkembangannya dan memiliki dampak negatif pada aspek kehidupannya. Hal ini menjadi sebuah urgensi agar dilakukannya suatu penelitian yang bertujuan untuk mengetahui keefektifan konseling kelompok Modification Mindful Self Compassion (MMSC) untuk meningkatkan self compassion peserta didik MA. Metode penelitian ini adalah eksperimen kuasi dengan nonequivalent control group design yang memiliki kelompok eksperimen dan kelompok kontrol. Subjek penelitian terdiri dari 5 peserta didik yang ditentukan melalui teknik non probability sampling dengan purposive sampling pada kriteria tertentu yaitu peserta didik merupakan kelas X di MAN 4 Kampar yang memiliki hasil skala self compassion dengan kategori rendah. Prosedur penelitian yaitu pra konseling kelompok, intervensi, dan pasca konseling kelompok. Pengumpulan data menggunakan angket dengan skala self compassion yang dilakukan secara pretest sebelum intervensi dan posttest setelah intervensi. Setelah data diperoleh, kemudian data diolah dengan menggunakan teknik analisis data yaitu analisis data deskriptif dan uji Wilcoxon. Hasil penelitian menunjukkan bahwa Konseling Kelompok Modification Mindful Self Compassion (MMSC) efektif untuk meningkatkan self compassion peserta didik MA
Investigating the Interplay of Academic Stress, Anxiety, and Sleep Disturbances in College Students
Authors: Rianti Nuras , Kholidin Farid Imam , Yandri Hengki
Published: July 2024

Poor sleep quality negatively affects students' cognitive abilities. Meanwhile, improperly managed academic stress and anxiety exacerbates sleep disorders, potentially impeding academic performance. This study aimed to examine the relationship between academic stress, anxiety, and sleep disorders among students. The research employed a quantitative, correlational design, with 109 students from Institut Agama Islam Negeri Kerinci, Indonesia, as research participants. Data were collected using instruments such as the Sleep Quality Scale (Cronbach's alpha 0.969), Academic Anxiety Scale (Cronbach's alpha 0.956), and Academic Stress Scale (Cronbach's alpha 0.980). The data were analyzed using descriptive statistics, as well as simple and multiple regression tests. The results indicate a correlation between the level of academic stress and academic anxiety and the incidence of sleep disorders in college students. In summary, higher levels of academic stress and anxiety increase the likelihood of individuals experiencing sleep disorders. It is expected that future research will expand the sample population to allow for more generalizable results for the student population.
Educational Cinema Techniques Guide for Accelerating Optimism Among Senior High School Students
Authors: Flurentin Elia , Setiyowati Arbin Janu , Mahardika Jasmine Anantiya
Published: July 2024

This study seeks to develop a group counseling guide media using educational cinema techniques to enhance students' optimism in State Senior High School 1 Singosari, Malang. This study adopted the Research and Development research model developed by Borg and Gall, comprising seven research stages, including: (1) data collection stage, (2) research planning stage, (3) initial product development, (4) trial phase, (5) product revision stage, (6) initial field trial phase, (7) final product stage. In this study, an instrument was employed to assess the acceptability of the prototype which had been developed. The data applied in this study was quantitative and qualitative data. The quantitative data was obtained using percentage descriptive techniques. Qualitative data was also obtained from criticism, suggestions, and input from experts and potential product users. The results of the service media expert test, service material expert test, and prospective users showed a high score. The obtained score indicates that the prototype meets the accessibility criteria of accuracy, usability, convenience, and attractiveness, as well as the criteria of being very accurate, very useful, very easy to use, and very interesting to use.
El teatro socialista en Portugal. Desde la fundación del Partido Socialista en Portugal al Estado Novo (1875-1933)
Authors: Peralta García Beatriz
Published: July 2024

Este artículo analiza el teatro escrito para ser representado —sin entrar a considerar, por lo tanto, los textos dramáticos, que son ejercicios literarios— por los obreros socialistas de Portugal entre 1875, fecha de fundación del Partido Socialista, y 1933, cuando se institucionaliza el Estado Novo. Nuestro trabajo se basa en la consulta de fuentes hemerográficas, en las obras teatrales que fueron impresas y en bibliografía crítica sobre el tema, y su objetivo consiste en inscribir esta dramaturgia en la historia del socialismo portugués, describiendo su impacto como respuesta a los desafíos del capitalismo industrial.
Joaquín Ruiz-Giménez e Izquierda Democrática (ID): Una utopía demócrata y cristiana para la transición española
Authors: Magaldi Adrián
Published: July 2024

Durante el tardofranquismo, la democracia cristiana aparecía como una de las ideologías con mayores opciones políticas en el nuevo escenario democrático que se abriría a la muerte de Franco. Estas expectativas muy pronto se dirigieron hacia la figura que entonces encarnaba la máxima representación de este espectro, Joaquín Ruiz-Giménez, presidente de Izquierda Democrática (ID). Pese a tales pronósticos, estos nunca llegaron a cumplirse. A través de material inédito procedente del archivo personal de Joaquín Ruiz-Giménez, este artículo pretende realizar un recorrido a través de la historia de ID, desde que Ruiz-Giménez asumió su presidencia en 1969 hasta su disolución en 1979. El objetivo es analizar los problemas ideológicos y estratégicos del partido, las relaciones y búsquedas de confluencias con otras formaciones, las dificultades introducidas por el contexto político español y la influencia de la singular personalidad de Ruiz-Giménez para así comprender las razones de uno de los fracasos más llamativos de la Transición.
Front Matter
Authors: Law Review Indiana
Published: July 2024

Includes Dedications in memory of R. Bruce Townsend by Debra A. Falender and Gerald L. Bepko.
The Robin Anomalad: A case report of genetic disorder with rare oral manifestations
Authors: Deotale Komal Ravindra , Lanjekar Ashish Babanrao , Madne Isha Ram , Jaiswal Raksha Bhagwan , Chincholkar Shraddha Damodar , Alhat Disha Vijay
Published: July 2024

This case report describes a case of non-syndromic Pierre Robin Syndrome (ns-PRS) in a 17-year-old male patient with unique oral characteristics, adding to the body of knowledge on unusual PRS presentations. There was enough literature to support all of the unusual findings reported in this instance leading to a precise diagnosis of Grade I ns-PRS. Some individuals with PRS might show all the typical signs, whereas others may appear with only rare signs. Such kind of more rare manifestations should be recognized and should be reported further to add credence to the literature on unusual manifestations of PRS.
Wrestling with Method. Dialectics and Phenomenology in Hegel and Berdyaev's Project for a New Philosophy
Authors: Woźniak Monika
Published: July 2024

Artykuł poświęcony jest problemowi metody filozoficznej w późnej twórczości Nikołaja Bierdiajewa, w której zaczął on krytykować ontologię za racjonalizowanie konkretnej egzystencji. Bierdiajew nazywa swój nowy projekt filozoficzny „fenomenologią doświadczenia duchowego”, a jego dzieła z tego okresu świadczą o wzrastającym zainteresowaniu Heglowską filozofią jako filozofią ducha i nowym, bardziej dynamicznym sposobem filozofowania. Z tego względu celem artykułu jest porównanie tych dwóch projektów: w pierwszej części tekstu, rekonstruuję Heglowski opis dialektyki i fenomenologii, by w drugiej zestawić je z opisem nowego filozofowania Bierdiajewa, ugruntowanym w jego epistemologii. Jak przekonuję, Bierdiajew kładzie nacisk na symbolizm, a uwypuklane przez niego elementy nowej filozofii nie są bezpośrednio inspirowane Heglem, lecz dużo mniej znanym projektem fenomenologii autorstwa Henriego-Frédérica Amiela.
Record of aphidophagous syrphids with their prey and host plants in India: A review
Authors: AHMAD MD. EQUBAL , KUMARI KIMMI
Published: July 2024

The article deals with the association of aphidophagous syrphids with their prey species and their host plants for programming the biocontrol approach against aphid pests. Aphids are tiny sap-sucking bugs and they are important phytophagous pests due to their polymorphism and rapid increase of their numbers by parthenogenetic development. Larvae of syrphids are the most important natural enemies of several sap-sucking insects and are useful bioagents in biological control programmes. After reviewing many articles 48 species of syrphids are recognised as predators of 72 aphid species infesting more than 141 plants of different families. Among these syrphids, Episyrphus balteatus was reported as a predator on maximum number of aphid species (43 species) followed by Ischiodon scutellaris (34 species), Eupeodes confrater (20 species), Betasyrphus serarius (18 species), Paragus serratus (17 species), and Allograpta javana (12 species).
Dynamics of distribution of vimentin and alpha-smooth muscle actin in the liver at the stages of regeneration after chemically induced fibros
Authors: Dvoryashina I. A. , Velikorodnaya Yu. I. , Zagrebin V. L. , Bykhalov D. Yu. , Smirnov A. V.
Published: July 2024

The aim of the study was to analyze the distribution of vimentin and alpha-smooth muscle actin (α-SMA) in the liver at various stages of regeneration after chemically induced fibrosis. Material and methods. Four experimental groups of animals were formed, consisting of white male rats representing different stages of liver recovery (no recovery, 4, 8, and 12 weeks of recovery) after chemically induced liver fibrosis, and a control group of intact animals, with 8 animals in each group. The dynamics of the distribution of intermediate filaments of mesenchymal cells were analyzed on preparations stained by immunohistochemical method using antibodies to vimentin and α-SMA. Results. After chemically induced liver fibrosis, a significant increase in the specific area of vimentin and α-SMA was observed, suggesting an important role of mesenchymal cells in the remodeling of the liver parenchyma. At the 4th week, the increased number of vimentin- and α-SMA-positive cells persisted, with these cells localized along fibrous septa and around blood vessels. At this stage, regenerative rosette-like structures consisting of vimentin- and α-SMA-positive mesenchymal cells surrounded by young regenerating hepatocytes were formed. By the 8th–12th weeks of regeneration, a decrease in the specific area of these markers was noted; however, vimentin- and α-SMA-positive cells were still present near portal triads and blood vessels, indicating ongoing regeneration processes. Conclusion. Vimentin and α-SMA play a key role in the formation of the fibrous matrix and the activation of perisinusoidal cells and myofibroblasts. The observed correlation between changes in vimentin and α-SMA indicates their coordinated involvement in the processes of fibrosis and regeneration.
Morphofunctional changes in cerebral motor cortex in experimental type I diabetes mellitus
Authors: Smirnov A. V. , Tyurenkov I. N. , Bisinbekova A. I. , Bakulin D. A.
Published: July 2024

The aim was to study morphofunctional changes in neurons in the motor cortex of rats with experimental type 1 diabetes mellitus (DM) and its pharmacological correction with mefargine, aminolone and succicard. Material and methods. Modeling of diabetes mellitus was performed on white mongrel female laboratory rats at the age of 12 months. The animals were divided into 5 groups: I – group of intact animals; II-1 – group of pharmacological correction with succicard, II-2 – correction with aminalon, II-3 – correction with mefargine and III – group of DM without treatment. DM was modeled by a single intraperitoneal administration of streptozotocin dissolved in citrate buffer (0.1 M, pH 4.5) (Sigma, USA) at a dose of 60 mg/kg after 48 hours of food deprivation. Treatment was started 6 months after the DM simulation. Statistical processing of the obtained results was carried out using descriptive and analytical statistics using Prism 6 software (GraphPad Software Inc., USA). Results. Histological examination of the motor cortex of intact rats (group I) revealed hyperchromic neurons in all the cortical layers. In group III, pronounced hyperchromatosis was observed in layers 2, 3, 5, in comparison with group I, a decrease in the area of pericaryons was revealed by 17.2% (p<0.001), the area of nuclei was less by 26% (p<0.001), there was a decrease in nuclear-cytoplasmic ratio (NCR) by 18% (p<0.001). The animals treated with succicard (II-1) showed the least pronounced neurodegenerative changes in comparison with groups I, II-2 (aminalon) and II-3 (mefargine). In group II-1, there was an increase in the area of pericaryons by 26% (p<0.001), the area of nuclei by 39.7% (p<0.001), and the NCR by 23% (p<0.001) compared with the group without treatment (I-1). Conclusion. Morphometric examination of the inner pyramidal layer of the motor cortex of the studied groups revealed the most pronounced pathomorphological changes in diabetic rats without treatment, which were expressed in a tendency to increase the content of damaged neurons, in a statistically significant decrease in the area of pericaryons and nuclei. The most pronounced neuroprotective effect was observed with the use of succicard.
Evaluation of the effect of oxytocin on structural and functional changes of the myocardium in experimental heart failure
Authors: Starchenko A. D. , Liskova Yu. V. , Stadnikov A. A. , Myasnikova A. A.
Published: July 2024

The aim of the study was to evaluate the effect of oxytocin on the structural and functional reorganization of the myocardium in experimental heart failure (EHF) Material and methods. Heart failure was modeled on mature rats of both sexes of the Wistar line (n=36). From the 7th day of the experiment, oxytocin was administered to animals with EHF at a dose of 0.5 U / kg of body weight daily intramuscularly for a week. The obtained material (heart, left ventricular (LV) myocardium) was studied by light microscopy, morphometry, and immunohistochemistry (expression of caspase-3, bcl-2, ki-67 proteins). Results. A comprehensive analysis of histological preparations showed that in heart failure, pathological changes occur in all structures of the LV myocardium (in cardiomyocytes (CMC), vessels of the microvasculature, connective tissue stroma). Against the background of the introduction of oxytocin, there is an increase in the volume density (VD) of cardiac myocytes, capillaries and a decrease in the VD of stromal components. Oxytocin inhibition of the proapoptotic dominant and activation of reparative processes in the myocardium were established: there was a decrease in the number of caspase-3-positive cardiac myocytes and an increase in CMC expressing bcl-2 and ki-67 in animals of both sexes with EHF. Under the influence of oxytocin, a more significant activation of regenerative and antiapoptotic potential was revealed in the group of females with EHF. Conclusion. The totality of the data obtained as a result of the study indicates the cardioprotective effect of oxytocin on myocardial structures in heart failure, characterized by stimulation of vasculogenesis, inhibition of fibrosis and apoptosis, and activation of cellular adaptive myocardial remodeling pathways. The biological effect of oxytocin on the myocardium is characterized by gender-specific features of the realization of its effects, which gives a new understanding of the role of the oxytocinergic system in the heart.
Histomorphometrical features of the ankle synovium in diabetic neuroosteoarthropathy complicated by chronic osteomyelitis
Authors: Stupina T. A. , Mezentsev I. N.
Published: July 2024

The role of the synovium in the pathogenesis of the Charcot foot is not properly studied; there is no information on its histomorphometric features. The aim of the study was to investigate the histomorphometric features of the synovial membrane in patients with diabetic neuroosteoarthropathy complicated by chronic osteomyelitis. Material and methods. Osteochondral fragments and fragments of the articular capsule of the ankle joint obtained from 35 patients were examined. Group 1 included patients with diabetic neuroosteoarthropathy accompanied by chronic osteomyelitis in the acute stage (n=26). Group 2 included patients suffering from diabetic neuroosteoarthropathy with chronic osteomyelitis in remission (n=9). The control group included individuals who did not suffer from diabetes mellitus and diseases of the musculoskeletal system (n = 7); the synovial membrane obtained during their autopsy was used for comparison. Histomorphometry was performed on paraffin and semi-thin sections stained with hematoxylin and eosin, as well as Masson trichrome stain, using an AxioScope.A1 microscope and Zenblue software (Carl Zeiss MicroImaging GmbH, Germany). Results. In patients of group 1, high-grade synovitis and hyperplasia of the integumentary layer were registered. In patients of group 2, mild synovitis and fibrosis of the integumentary layer were noted. In both groups, histological signs of microcirculation disorders were revealed. In the 1st group, there was an increase in the thickness of the covering layer by 1.5 times compared to the control; in the 2nd group, the values of this parameter were 1.7 times lower compared to the control parameters. In both groups, an increase in the numerical density of microvasculature vessels was recorded, being the most pronounced in patients of Group 1. Conclusion. A histomorphometric study of the synovial membrane of the ankle joints in patients with diabetic neuroosteoarthropathy allowed identifying a number of features of its restructuring in the form of reactive and degenerative-inflammatory changes at different inflammatory stages of chronic osteomyelitis.
The Influence of Sharia Compliance, Service Quality, and Promotion on E-Loyalty of Bank Jago Syariah Customers
Authors: Fitrihindika Fairul Firatasya , Puspita Sari Lili
Published: July 2024

According to the Bank Indonesia, the digital sector is poised for substantial growth, fueled by an expanding economic and digital financial ecosystem. A notable increase in digital bank accounts was observed in 2021, with 25% of adults owning one. Projections suggest this will rise to 39%, or approximately 74.8 million, by 2026. This research aims to evaluate how Sharia adherence, service quality, and promotional efforts impact the e-loyalty of Bank Jago Syariah’s customers, thereby aiding Islamic digital banks in navigating the swiftly evolving digital finance landscape. The research selected 150 Bank Jago Syariah customers from Jabodetabek through purposive sampling. SEM PLS was the analytical method employed, yielding an adjusted r-square of 0.574. This indicates that 57.4% of e-loyalty can be attributed to the variables of Sharia compliance, service quality, and promotion, while the remaining 42.6% may be influenced by factors not included in this study. Findings reveal that Sharia compliance had a significant positive effect on e-loyalty, as does service quality, whereas promotion does not. The research suggests that enhancing e-loyalty among Bank Jago Syariah customers can be achieved by consistently adhering to Sharia principles, improving service quality, and refining promotional strategies.
Keywords: Bank Jago Syariah, e-loyalty, service quality
Do Green Innovation, Carbon Emission Disks Affect Company Value with Environmental Performance as A Moderator?
Authors: Septiani Rahmalita , Hernawati Erna
Published: July 2024

This research is a quantitative study that aims to determine the effect of green innovation as measured by four indicators of disclosure items and carbon emission disclosure on company value, moderated by environmental performance. The sample of this research was taken from manufacturing sector companies listed on the Indonesia Stock Exchange in the 2020-2022 period, which were selected based on the purposive sampling method. Data were obtained from 37 companies, with a total sample size of 111. The results of the test indicate that (1) Green innovation does not have a significant influence on company value. (2) Carbon emission disclosure does not have a significant influence on company value. (3) Environmental performance does not strengthen the relationship between green innovation and company value, and (4) Environmental performance does not strengthen the relationship between carbon emission disclosure and company value. According to the results, it can be observed that these variables are less effective in influencing company value, suggesting the need for further research.
Keywords: company value, green innovation, carbon emission disclosure, environmental performance
FUNNY SITUATION AND FEATURES OF ITS IMPLEMENTATION
Authors: Mykhailiuk Oleksandr , Vershyna Viktoriia
Published: July 2024

Laughter is always conditioned, caused by an external influence, appears as an emotional reaction to something. Laughter presupposes an object for laughter – the funny. Laughter requires a laughable situation when this “something” can become funny. There are many conditions that determine where, when, and how a laughing situation can occur. As a rule, it arises as a result of violation of established rules of signification, disagreement of meanings, collision of meaning with nonsense, etc. Without a laughing situation, laughter becomes more of a symptom.
A funny situation in itself does not yet cause laughter, but is only a prerequisite, a condition, an opportunity for laughter. Not every situation can turn into a laugh. For a funny situation to be realized, it must be understood and interpreted accordingly. A funny situation is realized only if there is understanding – what is not understood is not funny. Funny becomes funny as a result of interpretation, if it is understood as funny. It depends on what meaning will be attributed to it. A laughing situation is a subjective-objective situation. The same message can generate different meanings for different recipients. Any situation allows for completely different interpretations. Realization of a laughing situation, laughter as such depends on the interpreter and the result of the interpretation. What we laugh at says more about ourselves than about the object of laughter.
WHEN BUDDHIST SCULPTURE SMILES
Authors: Levchenko Viktor , Zolotarova Kristina
Published: July 2024

The representational tradition of Buddhist sacred sculpture is multi-layered and has its own specificity, reflecting the stylistic and cultural-historical contexts of the regions where it has spread. The adoption of new trends, development in alternative dimensions, and transformation into original cultural artifacts accompany the philosophical principles of Buddhism throughout its pilgrimage journey. The smile is a unique attribute and phenomenon of Buddhist imagery, a marker of change, and a transformative response to the challenges of time.
In this article, we will examine vivid examples of such adaptations and changes, the specificity of Buddhist sacred sculpture, the spread of the smile in the representational tradition (under the influence of various factors), and the characteristic “signs of the times” that have been realized in the art and cultures of the regions where it has been universalized.
The smile can be considered one of the main attributes of Buddhist imagery; it has numerous variations in execution and is imbued with symbolic meanings and hidden senses. Buddhist sacred sculpture carries not only the specificity of traditions and schools but also reflects the cultural-historical context. Therefore, followers and disciples of certain representational traditions implemented them considering local specifics and peculiarities.
We find several characteristic examples of the use of the smile in sacred sculpture, which have an abnormal nature and stand out from the general dynamic system of Buddhist sacred sculpture, specifically in the cultures of East Asia and Cambodia.
SPATIAL TURNING: CHRONOTOPICITY OF BEING
Authors: Brodetska Yulia
Published: July 2024

The article analyzes the problems of methodological reconstruction of modern philosophy. These changes take place within the framework of philosophical “turns”, one of which is the “spatial turn”. It is noted that the transformative vectors of methodological reversions (ontological, linguistic, iconic, theological, performative, medial, anthropological, rhetorical, narrative, spatial turns) qualitatively change the format of the classical philosophical paradigm. Thus, the spatial turn prompts a rethinking of the concepts of “space”, “topos”, “locus” in the philosophical tradition. This brings the space phenomenon to the level of the same determining coordinate system of being as time. Spatial turn becomes the fundamental basis for changing the picture of the world. On its basis, other philosophical reversions are unfolding.
Spatial turn lays the foundations for the formation and interaction of all other reversals of modern philosophy. The analysis of the space phenomenon essentially shows an interest not in the imaginary “future”, but in the real “here” and “now”. In the coordinate system of a modern human, space appears visual and sensual. “Spatial turn” offers a new topos optics. Here, space and time as aspects of existence are not simply interconnected, but also actively influence human existence and change it. Within the framework of the new methodology, space comes to life and becomes an equal participant in socio-cultural changes.
The author notes that the very idea of a turn in modern philosophy is another historical attempt to change the methodological guidelines of philosophical knowledge. Because periodically calls for a “turn” appear in philosophy (for example, “back to nature”, “back to Kant”, “to Freud”, “to the things themselves”, “to the pre-Socratics”, “to myth”). However, the “spatial turn” becomes one of the fundamental conditions for a qualitative change in the methodological apparatus of modern philosophy.
“NEW VISUALITY”, IMAGE AND IMAGINATION IN THE CONTEXT OF NEW MEDIA ART
Authors: Barinova Yana
Published: July 2024

The publication examines the specifics of the image, imagination and the formation of “new visuality” in the context of the development of New Media Art. The analysis of the problem is carried out on two levels: a) conceptual searches of theorists of media philosophy, who proclaimed an iconic turn in modern culture and art; b) art projects of modern artists working in the field of new media art (technoart, bioart, software art, etc.). Modern philosophy in the light of new trends and socio-cultural practices understands the problems of correspondence between the image and the original, representation, the crisis of the concept of Image in modern art. It is about the formation of a new media narrative, which is capable of exploring new compositional possibilities offered, for example, by a computer database. The basic principles of new media are outlined: modularity, automation, variability, transcoding, etc.
THE CONTEMPORARY MUSEUM AS A COMMUNICATIVE SPACE: CLAIRE BISHOP’ CONCEPTION OF RADICAL MUSEOLOGY
Authors: Kovalova Nina , Levchenko Viktor
Published: July 2024

The article is devoted to the studying of dynamic changes in contemporary museology regarding the main functions, structure, communication aspects, conceptual and substantive content of contemporary museums. The authors pay special attention to the conception of radical museology of contemporary British-American art critic and cultural critic Claire Bishop. She singles out three existing models of museums, the last of which is a radical model. The radical model differs from the other two in its interpretation and using of the concept “modernity”. Modernity indicates not only a style or a period, but an affirmation of the present moment. The opposition between the concepts “modern art” and “contemporary art” is fundamental in museum practice. The latter, in contrast to the concept of “modern art”, is affirmed the significance of the current moment. The article pays considerable attention to the using of immersive technologies in contemporary museum work; various new museum practices are considered, where there are features of a radical attitude to the formation of modern expositions. The essential closeness of the concepts, “collector” in Walter Benjamin’s philosophy of culture and “curator” in the theory of radical museology by Claire Bishop is demonstrated.
PHILOSOPHIC AND CULTURAL GROUNDS OF DESTRUCTION IN THE TEXTS OF ARTISTS OF THE UKRAINIAN AVANT-GUARD
Authors: Shchokina Olena
Published: July 2024

The destruction is a specific frontier line of all the milestones in the history of culture, science, philosophy, and art. As a mighty annihilating power, the destruction enables separation, decomposition of the one and the whole. The Avant-garde, in fact, is a certain sibling and, at the same time, a consequence of the destruction. The destruction is an ideology and essence of the new consciousness, in general, and the Avant-garde culture of the early XX century, in particular. The destructive consciousness is a spawn of youth, carelessness, total lack of principles, and eclecticism of cultural processes. Any theoretical grounds, that provided by innovators and pretend for the absolute method in exploring and practice of the Art, are the acts of the Art by themselves which arise from its denial. The idea of innovation as such, and the integrity of destruction created a ground for the philosophic theorizing, paradoxes, and utopian thinking in the contemporary post-Avant-guard culture, philosophy, and art. Projecting the Avant-guard destruction at processes in the contemporary art, it is worth of mentioning that destroying of the ordinary manner of thinking, provocation of philistines and public, and clear declaration of the Avant-guard aggressiveness in manifests, public speeches, and cultural events demonstrate the strongly marked signs of destruction: the avant-gardists see the destruction as a necessary step to the unlimited freedom of personality; according to the Avant-guard theory, the concept of ‘Destruction’ is destroying the traditional conservative ideas about the man’s social roles; the fast movement towards absolute symbols, absolute ideas, and internal perfection, to the absolute itself was at a large scale caused by, and cause the destructiveness of the avant-gardists’ philosophic views. The destruction appears in a contemporary, still post-Avant-guard culture as a specific philosophic game, a theatre. Roles in this game were predetermined in the period of ‘domination’ of ideas and concepts of the classic Avant-garde art of the early XX century. Paradoxically, the Destruction became one of stages of establishing the Avant-garde, a simultaneous demonstration of utopia of its ideas, and finally its decline. The Destruction, as an extermination of any glimpses of dissent, was later reflected in the dictatorship of culture of the Soviet period.