bluuebunny/crossref_metadata_2025 huggingface dataset:
High-performing All-solid-state Sodium-ion Batteries Enabled by the Presodiation of Hard Carbon
Authors: Oh Jin An Sam , Deysher Grayson , Ridley Phillip , Chen Yu-Ting , Cheng Diyi , Cronk Ashley , Ham So-Yeon , Tan Darren H. S. , Jang Jihyun , Nguyen Long Hoang Bao , Meng Shirley Y.
Published: April 2023

All-solid-state sodium ion batteries (AS3iBs) are highly sought after for stationary energy storage systems due to their suitable safety and stability over a wide temperature range. Hard carbon (HC), which is low cost, exhibits a low redox potential, and a high capacity, is integral to achieve a practical large-scale sodium-ion battery. However, the energy density of the battery utilizing this anode material is hampered by its low initial Coulombic efficiency (ICE). Herein, two strategies, namely (i) thermal treatment and (ii) presodiation by thermal decomposition of NaBH4, are explored to improve the ICE of pristine HC. Raman spectroscopy, X-ray photoelectron spectroscopy and electrochemical characterizations elucidate that the thermal treatment increases the Csp2 content in the HC structure, while the presodiation supplies the sodium to occupy the intrinsic irreversible sites. Consequently, presodiated HC exhibits an outstanding ICE (>99%) compared to the thermally treated (90%) or pristine HC (83%) in half-cell configurations. More importantly, AS3iB using presodiated HC and NaCrO2 as the anode and cathode, respectively, exhibits a high ICE of 92% and an initial discharge energy density of 294 Wh kg_cathode^(-1)
High pressure-driven batch distillation optimal control for methyl acetate-methanol separation
Authors: Stojkovic Marija
Published: April 2023

The pressure-swing distillation process with high-pressurized batch columns (HHP), with and or without a recycling stream, for separating methyl acetate-methanol is studied from the aspect of optimal control. The results show that even though not heat integrated, the process using HHP benefits in productivity. Based on the maximum recovery, the dynamic controllability without any kind of heat integration is researched. The proposed process, however, has the economic potential of both capital and energy by internal heat integration, ie. connecting the reboiler of the lower high-pressurized column to the condenser of the higher high-pressurized column. In the future, even more azeotropes, both minimum and/or maximum boilers, should be investigated in order to establish a “heuristic guidance” for HHP design and industrial usage.
Antibacterial and Antioxidant Activity of Endophytic Fungi Extract Isolated from Leaves of Sungkai (Peronema canescens)
Authors: Oktiansyah Rian , Widjajanti Hary , Setiawan Arum , Nasution Sakinah Salman Ahmad , Mardiyanto Mardiyanto , Elfita Elfita
Published: April 2023

Sungkai is a plant that is widely found in Indonesia. This plant is often used in traditional medicine so the biotechnology of endophytic fungi is highly needed due to natural resources from plants that have been reduced. This study reported on endophytic fungi found in sungkai leaves and the compound produced. Morphological and molecular identification through phylogenetic tree analysis was carried out to determine the endophytic fungal species found. Potato Dextrose Broth media was used for the cultivation process. Ethyl acetate was used as a solvent for the extraction and the evaporation process used a rotary evaporator. Antioxidant and antibacterial tests were carried out using the DPPH method and paper disc diffusion. Chromatographic techniques were used to isolate the compound and spectroscopic analysis was performed to identify its chemical structure. The results of the morphological and molecular analysis showed Trichoderma asperellum as an endophytic fungus identified. The pure compound obtained from this endophytic fungus was 4-hydroxybenzoic acid. The antioxidant and antibacterial activity showed a strong category (IC50 = 43.88 ????g/mL; MIC 64 ????g/mL). This compound was very likely to be a raw material for new antibiotics and antioxidants through further research with various modifications.
Formulation of Set Covering Problem Using Myopic Algorithm and Greedy Reduction Algorithm in Determining the Location of Temporary Landfills in Semambu Island Village, Ogan Ilir Regency, South Sumatra
Authors: Puspita Fitri Maya , Octarina Sisca , Hanum Laila , Simamora Chatrin Yohana , Kemit Helena Valenta Br , Yuliza Evi
Published: April 2023

This study discusses Set Covering Problem (SCP) in designing the optimal temporary waste disposal site (TWDS) in Semambu Island Village using the Myopic Algorithm (MA) and Greedy Reduction Algorithm (GRA). The analysis was carried out and compared using a maximum distance of 500m and 1000m to get the best solution from two methods. The results of the p Median Problem by LINGO 13.0 software and MA with a maximum distance of 500m show the same TWDS location, namely Working Area (WA) 1, 2, 3, 4, 5, and 6 with the location of the candidate TWDS being at TWDS 2 WA 1, TWDS 1 WA 2, TWDS 2 WA 3, and TWDS 2 WA 5. For 1000m, it will be the location of the candidate’s TWDS being at TWDS 2 WA 1, TWDS WA 2, and TWDS 2 WA 3. Using GRA, results were obtained will be 4 TWDS, namely TWDS 2 Hamlet 1, TWDS 1 Hamlet 2, TWDS 2 Hamlet 3, TWDS 2, Hamlet 5. Then using GRA, 2 solutions are obtained, namely columns 2 and 5 which dominate. Column 2 nomination are Hamlets 1, 2, 3, and 6. Column 5 which dominates will be Hamlets 1, 3, 5, and 6.
Improving the Effectiveness of Learning with the Help of Neurocomputer Interface
Authors: Ronzhes Olena
Published: April 2023

The article considers modern technologies for reading signals from the human brain and nervous system and selects the optimal technology to improve the efficiency of adult learning with the help of a neurocomputer interface. Existing brain-computer interfaces (BCI) technologies can be divided into invasive and non-invasive. The first, invasive BCIs, are neuroimplants in certain parts of the brain that work on the basis of electrocorticography (ECOG) or intracranial EEG (iEEG) technology and do not require deep intervention in brain structures; or another invasive BCIs, based on intracortical recording technology using implants with electrodes placed in brain closer to the signal source, and required more complicate operation. The second, non-invasive BCI, reads signals from the brain and nervous system and is based on electroencephalogram (EEG). Compared to invasive BCIs with their more accurate signal, transcranial BCIs communicate with the brain through the skull bones, muscles, and all tissues. Their use does not require intervention in the human body. To increase the effectiveness of training, there was chosen a physiotherapeutic method of transcranial electrical stimulation (TES) in combination with a braincomputer interface based on electroencephalography (EEG), as the most accessible non-invasive method of exposure and feedback due to BCI without known side effects to mental functions and personality. The use of brain-computer interfaces, in particular transcranial electrical stimulation in combination with electroencephalography, increases cognitive abilities in learning, including multitasking. This method can also be used to increase the effectiveness of human assimilation of the necessary new digital environments and is used not only for training complex professions, but also for the masses. Side effects on higher mental functions and personality have not been sufficiently studied to recommend or avoid the use of neurocomputer interfaces for widespread use in education.
Reparação do retalho axial dorsal em ratos tratados com óleo ozonizado
Authors: Nakamura Aline Medeiros , Costa Marcelo Carrijo da , Gómez Jorge Luis Álvarez , Paiva Felipe Noleto de , Nardi Andrigo Barboza De
Published: April 2023

O retalho de padrão axial representa uma importante opção na cirurgia reconstrutiva, sendo composto por uma artéria e uma veia cutânea direta em sua base, permitindo que uma grande área de pele possa constituir o retalho para recobrir a ferida. Entretanto, a técnica pode apresentar complicações, principalmente com a necrose devido ao comprometimento vascular. Nesse contexto, a ozonioterapia pode ser utilizada para acelerar o processo de cicatrização de feridas pouco vascularizadas e contaminadas. Com o presente estudo, objetivou-se avaliar os efeitos e o reparo do retalho axial dorsal em ratos Wistar, empregando tratamento com óleo ozonizado de alta peroxidação. Utilizaram-se 18 ratos, distribuídos em dois grupos com 9 animais, grupo GG (óleo de girassol comum) e grupo GO (óleo de girassol ozonizado). Durante o período experimental foram realizadas avaliações macroscópicas e microscópicas a fim de observar a cicatrização e a reparação da ferida cirúrgica. Os dados foram submetidos a análise estatística.  O aspecto cosmético em GO foi significativamente melhor que GG, e a contagem de vasos sanguíneos, hemorragia e reepitelização foram significativamente maiores em GO quando comparado ao GG. A presença de necrose não diferiu entre os grupos. A média da área total dos retalhos entre os grupos diferiu estatisticamente, sendo maior nos retalhos em GO. Os resultados evidenciaram que a utilização do óleo ozonizado em retalhos de padrão axial resulta em aspecto favorável e melhor reepitelização.
Casuística dos diagnósticos histopatológicos de cães e gatos atendidos no município de Natal, Rio Grande do Norte
Authors: Melo Elizandra Teixeira , Frota Maria Luiza Sá de Lyra , Santos José Rodrigo Pontes dos , Fonseca Silvio Miguel Castillo , Correia Juliana Lucia , Pinto Carla Manuela Morais , Oliveira Anacleir Cruz de , Lima Telma de Sousa
Published: April 2023

Descrevem-se os diagnósticos histopatológicos de cães e gatos atendidos em Natal, Rio Grande do Norte, Brasil. Foram revisados os registros de biópsia de um laboratório de serviço patológico, dos quais se obtiveram informações sobre espécie, idade, sexo e perfil racial dos animais, além do padrão histopatológico das lesões. Para cálculo da faixa etária, considerou-se filhotes (até um ano de idade), adultos (de um a oito anos de idade) e idosos (acima de oito anos de idade). Os diagnósticos foram agrupados em lesões neoplásicas, inflamatórias e outros diagnósticos. Ao todo foram avaliadas 161 amostras referentes a 157 animais. Destes, 87,9% (138/157) corresponderam a cães e 12,1% (19/157) a gatos. 63,06% (99/157) corresponderam a fêmeas e 36,94% (58/157) a machos, enquanto 40,76% (64/157) eram adultos, 41,4% (65/157) eram idosos e 5,73% (9/157) eram jovens. 38,41% (53/138) dos caninos não tinha raça definida. 154 diagnósticos foram conclusivos, dos quais 63% (97/154) corresponderam a neoplasias, 22,08% (34/154) a inflamações e 14,94% (23/154) a outros diagnósticos. Quanto às neoplasias, o sistema tegumentar 48,45% (47/97) foi o mais afetado, seguido do sistema reprodutor e glândula mamária 32,99% (32/97) e oftalmológico 7,22% (07/97), destacando-se mastocitoma, lipoma, hemangioma e melanoma. Dentre as lesões inflamatórias, merecem destaque as alterações do sistema digestório e tegumentar, com ênfase para a gastroenterite linfoplasmocitária. No grupo outros diagnósticos, destacaram-se os infartos esplênicos, mucocele da vesícula biliar e as hiperplasias glandulares. Estudos que caracterizem o perfil histopatológico das lesões devem ser incentivados, pois fornecem um rol dos diagnósticos diferenciais para os veterinários da região.
A study to assess knowledge and attitude towards reopening of school during covid-19 pandemic among the parents of school going children in selected urban areas of the city
Authors: Deepali Shinde , Shital Padalkar
Published: April 2023

The COVID-19 disease originated from a corona virus identified in China in December 2019 and subsequently developed into a pandemic in 2020. In India, approximately 250 million students were affected by school closures at the onset of the lockdown in March 2020 due to COVID-19. The pandemic created several challenges in both public and private schools, including a rise in dropouts and learning losses. It is necessary to get back on track to give parents their childhood back and provide equal opportunities for children to chase their dreams. Therefore, parents must act quickly to reopen schools. A cross-sectional survey was conducted for the study. A convenient sampling technique was used to select 100 parents of school-going children in selected urban areas of the city. The data was collected in January 2022 and analyzed using descriptive and inferential statistics. The findings showed that 44% of parents' ages were between 26 and 31 years old, 69% of them were female, and the majority of families' monthly income was Rs. 10,001–15,000. Nearly 42% of parents had a primary education, and 35% of children were 7-8 years old, with 51% being male and 49% being female. The majority (32%) of children were studying in the 2nd grade. Most (52%) parents had good knowledge, 18% had moderate knowledge, and 30% had poor knowledge about reopening schools during the COVID-19 pandemic. In terms of attitude toward reopening schools, the majority (54%) had a positive attitude, 23% had a moderate attitude, and 23% had a negative attitude.
Narrativas (auto)biográficas sobre a formação e práticas interpretativas de professores violonistas
Authors: Silva Paulo Henrique Pereira Soares da , Monti Ednardo Monteiro Gonzaga do
Published: April 2023

Esta pesquisa tem como horizonte investigar a formação e as práticas interpretativas dos professores doutores e doutorandos que têm o violão como instrumento e que atuam em instituições federais de ensino em Teresina. Sendo assim, os objetivos específicos são: compreender como se deu a questão da performance na formação dos professores; entender como os professores desenvolvem a prática interpretativa nos alunos e analisar como ocorre a prática interpretativa dos professores. A fundamentação teórica acerca da performance musical ficou a cargo dos autores Cardassi (2000), Cerqueira; Zorzal e Ávila (2012), Henrique (2020), Souza (2008) e Zhumthor (2018). No que diz respeito ao ensino da performance musical, recolheu-se o Zorzal (2015) e Penna (2007). Tratando-se da (auto)biografia, utilizou-se as reflexões de Dominicé (2014) e Weller e Zardo (2013). Como metodologia da pesquisa, utilizamos a perspectiva (auto)biográfica, a partir da entrevista narrativa temática individual que abordou a formação e as práticas pedagógicas dos sujeitos da pesquisa e aconteceu com dois professores doutores que atuam no curso de Licenciatura em Música da Universidade Federal do Piauí (UFPI), e dois professores doutorandos do Instituto Federal do Piauí (IFPI), que também são professores do departamento de música. Os resultados da pesquisa indicam que para os professores, sujeitos da pesquisa, a performance musical, de certa forma, contempla a prática docente. Dessa forma, suas práticas educativas foram efetivamente influenciadas pelas suas práticas interpretativas.
O processo de inserção e orientação profissional de alunos egressos: Estudo de caso dos cursos técnicos do CEFET-Varginha/MG
Authors: Fuini Lucas Labigalini , Escandiussi Neto Luiz
Published: April 2023

O acompanhamento dos egressos dos cursos de educação profissional técnica de nível médio se torna fundamental para que a instituição escolar assuma o compromisso de melhoria da formação dos sujeitos que se encontram em transição para o mundo do trabalho, reforçando o papel educacional para a formação de cidadãos críticos e emancipados profissionalmente. Partindo dessas premissas, esta pesquisa teve como objetivo analisar, através de questionário semiestruturado, as relações dos egressos sobre seu processo de inserção profissional, satisfação na área de formação, condições laborais e avaliação institucional. Em seguida, foi traçado o perfil profissional dos técnicos em Edificações, Mecatrônica e Informática do CEFET-MG Varginha. Foram utilizados, como modelo de estudo, alunos formados entre os anos de 2014 a 2019 - integrado e subsequente. Baseando-se nas respostas dos questionários, foi desenvolvido um e-book de orientação profissional e gestão de carreiras para os profissionais e futuros profissionais. A hipótese levantada neste estudo considerou se um material educativo direcionado aos alunos e recém-formados contribuiria no processo de inserção profissional. A intenção, ao elaborar o recurso educacional, foi colaborar para reforçar a relação entre o egresso e a instituição de ensino, estendendo este relacionamento para além da formatura. Ao final, a aplicação do produto educacional e-book apresentou, de forma preliminar, um resultado positivo para sua utilização no processo de transição entre escola e mundo do trabalho.
Diagnóstico do perfil profissional demandado para o Técnico em Agropecuária no município de Cristalina-GO
Authors: Souza Álvaro Henrique Cândido de , Mendonça Yasmine Candida da Mata , Justino Rogério , Santos Georgia Silva , Marques Filho Wolff Camargo , Pinto Werusca Marques Virote de Sousa
Published: April 2023

O Técnico em Agropecuária é um profissional que possui conhecimentos e saberes relacionados à produção agropecuária, sendo sua atuação importante para o Brasil, tendo em vista que o país se destaca como os principais exportadores de produtos agropecuários do mundo. Com isso, torna-se importante manter atualizada a organização curricular dos Cursos Técnicos em Agropecuária para melhor atender as demandas destes profissionais. O objetivo deste trabalho foi elaborar e aplicar um questionário para diagnosticar as habilidades demandadas pelo mundo do trabalho para o profissional Técnico em Agropecuária. Espera-se que os resultados obtidos com este trabalho possam subsidiar a elaboração e/ou atualização dos projetos pedagógicos desses cursos em todo o Brasil. A técnica de investigação utilizada foi dividida em seis fases: I – Identificação, no projeto pedagógico, dos componentes curriculares do curso; II - Definição das cinco principais habilidades desenvolvidas em cada componente curricular; III - Elaboração de questionário para aplicação em entrevistas; IV - Aplicação do questionário por meio de entrevistas com produtores e empresários agropecuários locais; V – Tabulação dos dados e VI -Análise dos dados. Os resultados obtidos mostraram-se suficientes para serem utilizados como subsídio na reformulação do projeto pedagógico do curso.
PREVALENCE OF PD-L1 AMONG PATIENTS WITH METASTATIC TRIPLE-NEGATIVE METASTATIC BREAST CANCER (MTNBC) AND ITS ASSOCIATION WITH TUMOR-INFILTRATING LYMPHOCYTES (TIL)
Authors: Diniz Ana Carolina de Aquino , Sousa Romualdo Barroso de , Katz Artur , Pastorello Ricardo Garcia , Santos Maria Paula Furtado , Macedo Mariana Petaccia de , Linck Rudinei Diogo Marques
Published: April 2023

Objective: Immune checkpoint inhibitors (ICIs) combined with chemotherapy have emerged as the first line for patients with mTNBC whose tumors are PD-L1 positive. However, given the paucity of data in Brazilian populations, the objective of this study was to evaluate the prevalence of PD-L1 positive mTNBC in a single Brazilian center and its association with tumor-infiltrating lymphocytes (TIL). Methods: We assembled a retrospective cohort of all patients with metastatic breast cancer who have been tested for PD-L1 biomarker from January 2018 to December 2020. Patient’s clinical information, including use of ICI, and PD-L1 status, was obtained from the electronic medical record’s analysis, and the TIL slide’s material was reviewed by a single pathologist. TIL were assessed according to the international consensus and were classified as low, intermediate, and high TIL, respectively, if they present with 60%. Survival data (overall survival and progression-free survival) for TNBC patients who have been treated with immunotherapy are presented. Results: Among the 46 female patients tested for PD-L1 in our institution, 25 (54.4%) presented with mTNBC. Among this group (median age of 46 years), the majority was diagnosed between 2016 and 2020 (56%), in stages I or II (56%), and had invasive ductal carcinomas (96%). Most patients (23; 92%) underwent the SP-142 Ventana test, and the prevalence of positive (PD-L1 ≥ 1%) patients was 40%. Samples from primary tumor were more likely to be PD-L1 positive (9/17; 53%) compared with samples from metastatic sites (1/8; 12.5%) tumors. A total of 19 patients had TIL assessment. Most cases presented with low TIL (n=14; 73.7%), followed by intermediate TIL (n=5; 26.3%), and no cases of high TIL. Patients with PD-L1 negative tumors were more likely to present tumors with low TIL (9/11; 81.8%) versus those with PD-L1 positive tumors (5/8; 62.5%). A total of 13 patients received ICI plus chemotherapy. For this subset of patients, the median age was 47 years, 69.3% (n=9) had PD-L1 positive tumors, and most of them (n=12) received atezolizumab plus nab-paclitaxel. Only one patient received ICI as the first line. The median PFS was 2.36 months (2.4 months for PD-L1+ and 2.01 months PD-L1−). Two patients received the combination of ICI plus chemotherapy for >6 months. Disease progression was the main reason (64%) for ICI interruption. Only one patient stopped therapy for toxicity (neuropathy). Conclusion: To the best of our knowledge, this is the first “real-world” Brazilian study evaluating the prevalence of PD-L1 positive mTNBC and its association with TIL. The prevalence of PD-L1 in mTNBC is consistent with scientific literature, and physicians should prioritize performing the test in samples from primary tumors
COMPARATIVE ANALYSIS OF THE DEGREE OF PATIENT SATISFACTION AFTER BREASTCONSERVING SURGERY WITH OR WITHOUT ONCOPLASTIC SURGERY: A SYSTEMATIC REVIEW AND META-ANALYSIS
Authors: Lisboa Fabiana Christina Araújo Pereira , Veras Lucimara Priscila Campos , Paulinelli Régis Resende , Sousa João Batista de
Published: April 2023

Objective: A systematic review was carried out on the comparative analysis of the degree of satisfaction of patients undergoing breast-conserving surgery for the treatment of breast cancer, with and without oncoplastic surgery, in addition to performing a meta-analysis to integrate the results of studies carried out with different questionnaires to arrive at a summary measure that could homogenize and categorize this complex comparative analysis arising from such diverse quantitative collection methods. Methods: Systematic review with literature searches in MEDLINE (by PubMed), EMBASE, ClinicalTrials, Scopus, Web of Science, BVS, and OpenGrey. The Joanna Briggs Institute tools were used to evaluate the methodological quality of the studies. Data were summarized through meta-analyses using a random effects model and considered relative risk (RR) measures and their confidence intervals (95%CI). Results: After eligibility assessment, we included 6 studies in the systematic review and in the quantitative analysis, encompassing a total of 1,110 patients. The studies included seemed to have an overall good methodological quality. There was no statistically significant difference in the aesthetic outcome between women who underwent oncoplastic and conservative surgery (RR=0.98; 95%CI 0.91–1.04). Patients undergoing conservative surgery with oncoplastic surgery have more advanced staging, greater tumor size, and resected specimen weight compared to classical surgery. In addition, a higher frequency of breast tumor location is unfavorable to the best aesthetic result (central, medial, or inferior). Conclusion: The degree of patient satisfaction with conservative surgery, with or without oncoplastic surgery, is similar between the groups. The time elapsed from the surgery to the measurement of the outcome, and the tumor conditions seem to have an impact on this result. There is no specific or standardized questionnaire to assess patient satisfaction with conservative surgery, bringing limited and controversial results. Standardization in the quantification of these data in further studies is suggested.
MULTI-CENTRE PROSPECTIVE EVALUATION OF NEGATIVE PRESSURE WOUND THERAPY (NPWT) IN PATIENTS UNDERGOING ONCOPLASTIC BREAST SURGERY
Authors: Khosla Muskaan , Vidya Raghavan , Baek Kim , R Vinayagam , Prusty Lydia , Thekkinkattil Mr Dinesh , Laws Siobhan , Douvetzemis Stergios
Published: April 2023

Objective: Oncoplastic breast surgery is well-established but has a higher risk of wound complications. This may result in a delay in receiving adjuvant therapy, increased hospital visits with associated financial implications, and sub-optimal cosmetic outcomes. Negative pressure wound therapy (NPWT) has emerged as an additional tool to reduce wound complication rates, but further evaluation is required to evaluate its efficacy. This study investigated the prophylactic use of PICO® NPWT in patients undergoing oncoplastic breast surgery. We determined the rate of wound-related complications, including dehiscence, necrosis, implant loss, and infection. We compared our findings with data from the National Mastectomy and Breast Reconstruction Audit 2011 (NMBRA) and implant-based Breast Reconstruction Audit (iBRA). Methods: This was a prospective multi-centre national audit. The participating UK breast units routinely used NPWT for oncoplastic breast surgical procedures. Data collection included rates of wound dehiscence, wound necrosis, wound infection, and implant loss. The study findings were compared against the NMBRA and the iBRA studies. Results: Data from 267 patients were included in the study from 7 centres. The mean duration of PICO use was 6.6 [SD 1.9 days]. In all, 36 patients (13.5%) developed post-operative wound complications; 16 patients (6%) developed skin flap necrosis; wound dehiscence occurred in 13 patients (4.9%); and 15 patients (5.6%) developed post-operative wound infection. Of the whole cohort, 11 patients (4.1%) required further surgery due to wound complications, and 8 patients (3%) had a delay in the receipt of adjuvant therapy. A total of 158 patients underwent mastectomy with immediate implant-based breast reconstruction. The post-operative wound complication rate was comparable in this subgroup (n=22; 13.9%). Skin flap necrosis was seen in 10 patients (6.3%), wound dehiscence was seen in 7 patients (4.4%), and 8 patients (5.1%) developed wound infection. The implant loss rate was 3.8%. The estimated total cost savings were ￡84,613 and ￡316.90 per patient. Conclusion: This study suggests that prophylactic use of NPWT in oncoplastic breast surgery results in a low rate of wound-related complications with associated healthcare cost benefits. A prospective randomised controlled trial is required to further evaluate the prophylactic use of NPWT in oncoplastic breast surgery.
EFFECT OF ACUPUNCTURE AND EXERCISE THERAPY ON MUSCULAR STRENGTH, LYMPHEDEMA, AND QUALITY OF LIFE IN BREAST CANCER SURVIVORS
Authors: Giron Patricia Santolia , Haddad Cinira Assad Simão , Rizzi Samantha Karla Lopes de Almeida , Elias Simone , Nazário Afonso Celso Pinto , Facina Gil
Published: April 2023

Objective: The aim of this study was to compare three distinct rehabilitation treatments (exercise therapy, acupuncture, and Stiper®) in women undergoing breast cancer surgery, assessing strength, lymphedema, and quality of life. Methods: In all, 79 women with pain above 3 on the visual analog pain scale (VAS) and with more than 90 days of surgery were included. They were divided into three groups that received weekly treatment for 10 weeks: group I (G1) treated with standard, predefined exercise therapy, based on stretching of the cervical muscles, shoulder girdle, and shoulder ROM exercises with a duration of 30 min; group II (G2) treated with 30 min of acupuncture using predefined points; and group III (G3) treated with the same acupuncture points as group II, however, using the Stiper® (silicon oxide micronized quartz pellet) in place of needles. Results: A total of 67 patients completed the treatment – 26 from G1, 23 from G2, and 18 from G3. There was an improvement in upper limb muscle strength over time in all groups, except for abduction and internal rotation movements. During treatment, there was no increase in the number of patients with lymphedema, and there was no statistical difference between the groups. Regarding the EORTC QLQ-C30 quality of life questionnaire, 9 of the 15 factors analyzed showed significant differences between sessions. The factors that did not have significant differences between the three groups were social function, nausea and vomiting, dyspnea, loss of appetite, constipation, and diarrhea. Conclusion: The rehabilitation of physical dysfunctions in women who survived breast cancer through exercise therapy, acupuncture, and Stiper® in upper limb muscle strength, lymphedema, and quality of life proved to be effective without superiority between groups, which leads to the conclusion that acupuncture showed equivalence of results when compared with exercise therapy, thus being an effective approach for the rehabilitation of these women.
A POLÍTICA DO TRANSPORTE ESCOLAR NA REDE PÚBLICA MUNICIPAL DE EDUCAÇÃO DE TERESINA
Authors: Moura Ana Paula Monteiro de
Published: April 2023

A pesquisa ora desenvolvida adequa-se, mais
especificamente, a definição do autor sobre a análise e avaliação
de programas e políticas educacionais específicas, uma vez que
trata-se de um estudo que analisou a política de financiamento e
de atendimento do transporte escolar na Rede Pública Municipal
de Educação de Teresina (PI), no período de 2012 e 2013.
Understanding Phantom Oil
Authors:   King Abdullah Petroleum Studies and Research Center
Published: April 2023

Phantom oil is oil that is deliberately moved from legally recognized sources or traded in the black market. It is also frequently referred to as illegal, illicit, tacit, or unregistered oil. This oil is generally concealed from the energy community for various reasons, including to evade sanctions and to profit from cross-market price differentials. This arbitrage opportunity can be attributed to the existence of price incentives, taxes, and loose institutional structures.
Development of Medicinal Products Based on Gene-Editing Technology: Regulatory Practices
Authors: Pokrovsky N. S. , Vodyakova M. A. , Melnikova E. V. , Merkulov V. A.
Published: April 2023

Somatic cell genome-editing systems are the most recent gene therapy technology to treat patients with monogenic hereditary cancer or HIV. Gene editing allows for changing or completely removing a defective gene with regularly interspaced short palindromic repeat (CRISPR), zinc-finger nuclease (ZFN), and transcription activator-like effector nuclease (TALEN) systems.

The aim of the study was to analyse the existing international experience and regulatory requirements relating to the development of medicinal products based on genome editing of postnatal somatic cells.

This article describes the mechanism of action of CRISPR, ZFN, and TALEN systems and compares their advantages and disadvantages. Regulatory and legislative authorities should take a special approach to the development, manufacture, and assessment of medicinal products based on genome editing, as well as to the ethical aspects of their use. Current requirements and recommendations for the development of medicinal products based on genome editing are mostly limited to the need to evaluate the risks of off-target effects and late-onset adverse events and the possibility to adapt clinical trial design to surrogate endpoints, exclude healthy volunteers and comparison groups, and select initial doses for clinical trials based on scientific data. Thus, a regulatory approach should also be developed for the marketing authorisation of medicinal products based on genome-editing systems.
Self-Cultural Description Of The New Career Experience Of Dropout Athletes: Discussion On The Concerns Of Former Athletes And Secondary School Physical Education Teachers And Student Athlete Policies
Authors:   Korean Association for Qualitative Inquiry, Kim Chan Ul , Lim Jin Sun , Park Ji Won
Published: April 2023

This study describes the importance of basic academic skills of elite sports athletes and the improvement and realization of student athlete policies by describing secondary physical education teachers’ student athlete days, new career exploration and preparation process, and result experiences as secondary physical education teachers through self-cultural descriptions. It aims to find out how. As a research method, I tried to interpret it based on the retrospective memory of ‘I’ as a researcher and research participant as a self-cultural description and the result experience as a secondary physical education teacher. The results of this study are presented as follows. First, it was found that student-athletes’ academic disregard and lack of basic academic ability began when they were part of the school sports team and learned their culture. Second, college athletes who felt uncertain about the future decided to drop out, and thereafter, there is difficulty in exploring and challenging new career paths. Third, the dysfunction of elite sports is being repeated in schools. As a conclusion, first, the minimum educational attainment system needs to be reformed and objectivity for subjects secured, and the minimum educational attainment system to be improved for the issue of equity arising from differences in levels and evaluation methods of each school. Second, it is necessary to study the change in perception that student athletes, parents, and school sports departments are policy beneficiaries, and the selection criteria for student athletes to belong to school sports teams. Third, it is necessary to meaningfully apply the minimum grade system for the college entrance exam and the minimum academic level standard so that studies and sports can be combined.
Manejo actual del adenoma de la ampolla de Vater
Authors: Solano Jaime , Cabrera Luis Felipe , Pinto Renzo , López Rocío
Published: April 2023

A lo largo de la historia, el manejo de los tumores periampulares, malignos o benignos, ha sido la cirugía radical. Sin embargo, la gran complejidad de estos procedimientos, sus complicaciones y su alto índice de mortalidad hicieron impulsar el desarrollo de nuevas técnicas quirúrgicas mínimamente invasivas. Se presenta el caso clínico de una paciente de 55 años, con hallazgo incidental de un adenoma de la ampolla de Vater en una endoscopia de vías digestivas altas, T1 N0 M0 , manejado con papilectomía endoscópica, sin complicaciones y con márgenes negativos en el estudio histopatológico de la pieza quirúrgica. La papilectomía endoscópica, fue reportada por primera vez por Ponchon, et al., en 1989. La presentación clínica del adenoma de la ampolla de Vater es asintomática y su diagnóstico es incidental en la endoscopia de vías digestivas altas. El diagnóstico de este tipo de neoplasia se hace teniendo en cuenta la apariencia endoscópica y la histología; por lo tanto, es vital la utilización de un duodenoscopio lateral para poder tener una evaluación completa de la papila. Es importante practicar una ultrasonografía endoscópica biliopancreática, ya que esta determina la profundidad de la lesión y, además, permite descartar adenomegalias locales o regionales. La papilectomía endoscópica es un procedimiento que requiere de manos experimentadas para disminuir el riesgo de complicaciones.
Anestesia local para hernia inguinal mediante bloqueo ilioinguinal-iliohipogástrico
Authors: Aragón Felipe Jorge , Hernández José Miguel , Robaina Cristina Robaina , Incapié Jeysson David , Rivas Jesús Alexander
Published: April 2023

Introducción. La hernia inguinal es uno de los padecimientos más comunes que ameritan manejo quirúrgico y puede ser reparada utilizando anestesia local. El bloqueo ilioinguinal-iliohipogástrico es una técnica novedosa y poco evaluada para practicar la hernioplastia inguinal. Objetivos. Evaluar la seguridad y la efectividad de esta técnica en nuestro medio hospitalario. Material y métodos. Se llevó a cabo un estudio observacional y prospectivo que incluyó a todos los pacientes operados con anestesia local por la técnica del bloqueo ilioinguinal-iliohipogástrico, desde el 2009 hasta el 2014. Se estudiaron las variables demográficas, el tipo de hernia según la clasificación de Nyhus, las técnicas quirúrgicas empleadas, el tiempo quirúrgico, las complicaciones posoperatorias inmediatas (menos de 30 días) y el dolor posoperatorio evaluado mediante la escala visual análoga a las 24 y 72 horas, y a los 10 y 30 días. Resultados. La hernia inguinal indirecta se presentó en 409 pacientes (88,3 %). Los defectos de la pared posterior representaron el 11,6 %. El 63,9 % de los casos fueron tratados a base de prótesis y el 8,2 % tuvieron algún tipo de complicación sin relación con la técnica anestésica, en los primeros 30 días del posoperatorio. Los valores medios de la escala visual análoga fueron bajos para las primeras 24 horas y 30 días. El nivel de aceptación del método anestésico fue de 95,5 %. Conclusiones. La hernioplastia inguinal con anestesia local mediante bloqueo ilioinguinal-iliohipogástrico es una técnica factible, segura y efectiva para este tipo de operación, lo que la hace ideal para su aplicación en centros quirúrgicos de cualquier nivel y en lugares con recursos limitados
Manejo del divertículo de Zenker con endoscopia avanzada
Authors: Peñaloza-Ramírez Arecio , Rodríguez-Monguí Jaison , Murillo-Arias Andrés , Carvajal-Flechas Ricardo , Aponte-Ordóñez Pedro
Published: April 2023

El divertículo de Zenker es un saco que protruye a través de los músculos constrictor inferior de la faringe y cricofaríngeo (triángulo de Killian); es una alteración que ocasiona disfagia como síntoma principal y se puede manejar con el endoscopio flexible con buenos resultados. Objetivo. Describir la experiencia preliminar en el manejo endoscópico del divertículo de Zenker en el Hospital de San José. Métodos. Se trata de una serie de casos llevada a cabo desde diciembre de 2014 hasta abril de 2016 en el Hospital de San José, en la cual se utilizó el endoscopio flexible para la diverticulotomía en pacientes ambulatorios. Resultados. Se intervinieron seis pacientes, en los cuales se llevaron a cabo nueve procedimientos. El diagnóstico se hizo mediante esofagogastroduodenoscopia y esofagograma. La edad promedio fue de 65 años y cuatro pacientes eran hombres. En todos se practicó el procedimiento bajo anestesia general, usando endoscopio flexible, sonda orogástrica y capuchón. No se usaron antibióticos profilácticos y todos los pacientes se atendieron en forma ambulatora. Conclusión. La diverticulotomía endoscópica con equipo de endoscopia flexible es una técnica que ha sido adoptada por los gastroenterólogos intervencionistas debido a su seguridad y buenos resultados. Por lo anterior, esta técnica se debe tener en cuenta en los pacientes con esta enfermedad.
PEMBERDAYAAN TANAMAN HERBAL PENGELOLAAN JAMU RUMAHAN DI DESA KOLAM KANAN KABUPATEN BARITO KUALA
Authors: Chandriyanti Ika , Sopiana Yunita , Sa’roni Chairul , Suherty Lina , Fahrati Eny , Maulina Dessy , Pahlevi Khairi , Suherty Lina
Published: April 2023

Kegiatan pengabdian kepada masyarakat (PKM) di didesa Kolam Kanan Kecamatan Wanaraya Kabupaten Barito Kuala,  dengan melihat beberapa mata pencaharian pengolah dan penjual jamu selain usaha mereka bertani dan berladang, usaha jamu yang dijalankan mereka selain sebagai mata pencaharian sampingan akan tetapi rutin dilakukan, untuk jamu cair sudah mereka lakukkan dari dahulu, sedangkan pembuatan jamu kering dalam kurun waktu 2 (dua) tahun berjalan dan ini dilakukan pada saat masa pandemic Covid-19  dimana kebutuhan akan suplemen dari rempah-rempah yang disarankan untuk di konsumsi masyarakat oleh tenaga medis sebagai upaya pencegahan Covid-19, pengerjaan mereka masih menggunakan alat-alat tradisional, seperti alu untuk menghancurkan rempah-rempah yang dijemur atau dikeringkan. Kegiatan pengabdian dilakukan beberapa tahapan, pada tahap pertama dilakukan dengan metode penyuluhan dalam bentuk ceramah, diskusi dan tanya jawab mengenai higenis dari jamu tersebut, kemasan serta teknik pemasaran baik dengan menggunakan dengan cara menjual ke sekeliling kampung maupun dalam bentuk media sosial (penjualan online) kepada masyarakat luas. Peserta yang mengolah hasil olahan jamu tersebut dapat mengajukan berbagai pertanyaan maupun menceritakan kendala-kendala dalam memproduksi hasil olah jamu mereka dalam upaya meningkatkan pendapatan keluarga dan pengembangan ekonomi masyarakat penjual jamu. Pada tahap kedua penyuluh terjun langsung ke masyarakat penjual jamu dalam rangka meninjau keseharian kegiatan produksi usaha pengolahan hasil jamu mereka, serta memberikan pengarahan mengenai ekonomi kreatif dan tepat guna serta bisa mengelola usaha dengan menggunakan teknologi berbasis multimedia.
CUIDADOS DE ENFERMAGEM NO TRATAMENTO DE FERIDAS ONCOLÓGICAS EM MULHERES COM C NCER DE MAMA.
Authors: Pereira Dias Thais , Barreto Bruna , Ferraz Gomes Helena , Campos Oliveira Bianca , Márcia Peres Ellen , Brandão Salles Eliane
Published: April 2023

Objetivo: Analisar as produções científicas relacionadas com os cuidados de enfermagem no tratamento de feridas oncológicas em mulheres com câncer de mama. Método: Trata-se de uma Revisão integrativa da literatura, realizada de dezembro a abril de 2022. Foram realizadas as pesquisas em todas as bases de dados contidas na Biblioteca Virtual em Saúde: (LILACS) Literatura Latino Americana e do Caribe em Ciências da Saúde, (MEDLINE) Literatura Internacional em Ciências da Saúde, Biblioteca Cochrane, (BDENF) Base de dados de Enfermagem e (SciELO) Scientific Electronic Library Online. Os descritores foram determinados a partir das ferramentas (DeCS) Descritores em Ciências da Saúde. Selecionou-se os seguintes filtros: idioma, incluindo-se apenas publicações em português e espanhol, com um recorte temporal de publicações nos últimos dez anos (2012 a 2022). Resultados: Foram selecionados três estudos que destacaram a importância do uso correto das coberturas indicadas para cada estágio da lesão, de acordo com suas características, apontam ainda, o déficit de conhecimento científico no manejo das lesões por enfermeiros. Considerações Finais: Há a necessidade da implantação de protocolos de manejo clínico na assistência a essas pacientes portadoras de feridas oncológicas. Com a finalidade de proporcionar uma maior experiência para esses profissionais dos cuidados ideais e, sobretudo, conscientizá-los da importância dos registros no processo de enfermagem durante a assistência prestada.

Palavras-chaves: Neoplasias da Mama; Cuidados Paliativos; Cuidados de Enfermagem; Ferimentos e Lesões.
Using Item Scores and Distractors to Detect Item Compromise and Preknowledge
Authors: Gorney Kylie , Wollack James A. , Sinharay Sandip , Eckerly Carol
Published: April 2023

Any time examinees have had access to items and/or answers prior to taking a test, the fairness of the test and validity of test score interpretations are threatened. Therefore, there is a high demand for procedures to detect both compromised items (CI) and examinees with preknowledge (EWP). In this article, we develop a procedure that uses item scores and distractors to simultaneously detect CI and EWP. The false positive rate and true positive rate are evaluated for both items and examinees using detailed simulations. A real data example is also provided using data from an information technology certification exam.
Optimum Dimensions of Hydraulic Structures and Foundation Using Genetic Algorithm coupled with Artificial Neural Network
Authors: AL-Suhaili Rafa H. , Abbood Dheyaa W. , Saleh May Samir
Published: April 2023

A model using the artificial neural networks and genetic algorithm technique is developed for obtaining optimum dimensions of the foundation length and protections of small hydraulic structures. The procedure involves optimizing an objective function comprising a weighted summation of the state variables. The decision variables considered in the optimization are the upstream and downstream cutoffs lengths and their angles of inclination, the foundation length, and the length of the downstream soil protection. These were obtained for a given maximum difference in head, depth of impervious layer and degree of anisotropy. The optimization carried out is subjected to constraints that ensure a safe structure against the uplift pressure force and sufficient protection length at the  downstream side of the structure to overcome an excessive exit gradient. The Geo-studio software was used to analyze 1200 different cases. For each case thelength of protection (L) and volume of structure (V) required to satisfy the safety factors mentioned previously were estimated for the input values, namely, the upstream cutoff depth (S1), the downstream cutoff depth (S2), the foundation width (B), the angle of inclination of the upstream cutoff (Ɵ1)  and the angle of inclination of the downstream cutoff (Ɵ2), H (differencehead), kr (degree of anisotropy) and D (depth of impervious layer). An ANN model was developed and verified using these cases input-output sets as its data base. A MatLAB code was written to perform a genetic algorithm optimization modeling coupled with this ANN model using a formulated optimization model. A sensitivity analysis was done for selecting the crossover probability, the mutation probability and level,the number of population, the position of the crossover and the weights distribution for all the terms of the objective function. Results indicate that the most factors that affects. the optimum solution is the $ number of population required. The minimum value that gives stable global optimum solution of this parameter is (30000) while other variables have little effect on the optimum solution.
Experimental study on performance of laterally loaded plumb and battered piles in layered sand
Authors: Albusoda Bushra S. , Alsaddi Anmar F.
Published: April 2023

This study introduces a series of single and pile group model tests subjected to lateral loads in . multilayered sand from Karbala, Iraq. The aim of this study is to investigate: the performance of the pile groups subjected to lateral loads; in which the pile batter inclination angle is changed; the effect of pile spacing (s/d) ratio, the influence of using different number of piles and pile group configuration. Results revealed that the performance of single negative (Reverse) Battered piles with inclination of 10° and 20° show a gain of 32% and 76 % in the ultimate lateral capacity over the regular ones. For pile groups, the use of a combination of regular, negative and positive battered piles in different angles of inclination within the same group shows a significant increase in the ultimate lateral load carrying capacity. Increasing the spacing between piles in groups of the same category shows an increase in the group efficiency, also changing the piles number within the group by using different patterns will influence the ultimate lateral resistance of the pile group.
Optimal Indicators to Select the Engineering Consultancy Office For Higher Education Institutions in Iraq
Authors: Altaie Meervat
Published: April 2023

Expansion the engineering consultancy offices in the universities of Iraq, about (14) offices, leading to increas the competition between them, especially after the great trends of Iraqi government agencies to use the academic experiences and their efficiencies in general, due to non-existence of the engineering qualification in the government institutions to do the engineering designs ,supervision of projects and other engineering works which are practicing by the engineering consultancy offices in order to get the best performance of the work.Within this serious competition, needing a specific approach to enable government agencies to choose the optimal and alternative consultancy office to meet specific project and not rely on cronyism and personal relationships that have become prevalent in Iraq and causing administrative corruption, which will not achieve the owner requirements and thus will affect the requirements needed in the project .  The researcher used the descriptive analysis to describe and evaluate the results of the study using the sign test which is a non-parametric test, appropriate in ordinal data. Decision makers can use the final results to select the suitable engineering office, it can be regarded as an important database through the support of the basic criteria and subcriteria used in the analysis compiled by a researcher from the International and Arab refernces as well as a realistic local criteria in Iraq.