bluuebunny/crossref_metadata_2025 huggingface dataset:
El don de narrar: el concepto de narración en Walter Benjamin y en los textos jasídicos
Authors: Yutzis Daniela
Published: October 2021

El presente trabajo tiene por objeto delinear aquellos conceptos centrales de la narración en Walter Benjamin que se despliegan en las lecturas de los cuentos y relatos que forman parte del corpus central del movimiento jasídico. Para ello se analiza la concepción de la experiencia, el uso de las palabras y las alusiones del narrador en ese instante en que, a través del consejo, el maestro (el justo, el Tzadik) transmite sabiduría. El consejo no es una respuesta cerrada ni un saber exclusivo sobre los aspectos metafísicos, sino que es –ante todo– la transmisión del aspecto de unificación del mundo, donde lo cotidiano devela su carácter inexplicable y lo trascendental –en un instante fugaz– se aproxima a la vida misma. Lo que narra el maestro jasídico sucede entre el cielo y la tierra, entre la vida práctica y la mística. La narración no abrevia: se despliega, da cuenta de lo inacabado, del requerimiento de la tarea del hombre en el mundo, de la labor paciente, insistente, del constructo de una artesanía que sólo la convicción –aquello más allá del mero y puro intelecto– y el amor a la letra del texto sagrado puede reavivar.
El problema formas/vida y el estructuralismo vitalista de Jakob von Uexküll
Authors: Heredia Juan Manuel
Published: October 2021

El artículo analiza el sentido histórico-conceptual que asume la teoría de Jacob von Uexküll sobre el fondo del problema formas/vida que se despliega en la filosofía continental de principios del siglo XX. Para ello, en primer lugar, reconstruye la configuración epistemológica que presenta el pensamiento biológico entre 1890-1920, e introduce las tesis neovitalistas de Hans Driesch. En segundo lugar, analiza la emergencia de las metafísicas vitalistas de Henri Bergson y de Georg Simmel, y plantea el problema de la contradicción entre las formas y la vida. Por último, y sobre la base de dichos desarrollos, defiende la tesis según la cual la obra de Uexküll moviliza un estructuralismo vitalista para el cual “Vida igual a Forma”.
Methods and tools for the development of a Product-Service System: Proposal of a conceptual model
Authors: Tokarz Barbara , Kohlbeck Eloiza , Beuren Fernanda Hänsch , Fagundes Alexandre Borges , Pereira Delcio
Published: October 2021

Goal: Present a holistic perspective of methods and tools for the development of Product Service Systems (PSS).

Design/Methodology/Approach: The investigation was conducted in two phases. The first phase presents bibliographic and bibliometric analyses, where 132 papers were read in full. In the second stage, of conceptual development, bibliographic data was grouped and validated by PSS specialists through a questionnaire, whose responses were used to conceptualize a model for PSS development.

Results: Elaboration of a concept of a model for the development of Product-Service Systems, capable of providing guidance for all stages of its life cycle.

Limitations of the investigation: The proposed model was applied to the bike sharing business model. However, a limitation was the lack of some information regarding this case to apply some methods and tools proposed in the conceptual model.

Practical implications: The model developed can be used as a guideline for the elaboration or improvement of a PSS proposal, since it provides structure and control to the business models.

Originality/Value: The paper demonstrates its originality and relevance by presenting a model centered on a holistic approach, as it provides a perspective of the whole PSS life cycle. Thus, processes are planned and analyzed from the definition of requirements to the destination after use of the PSS.
Age-based immunomorphological analysis of rat testis in streptozotocin-induced diabetes mellitus
Authors: Kondrat I.-A. V. , Shponka I. S. , Shynkarenko T. V.
Published: October 2021

Diabetes mellitus (DM) has emerged as a public healthcare problem. Sustained hyperglycemia has been linked with many complications including impaired male fertility.
The aim of the study: to evaluate the effect of STZ-induced diabetes mellitus on testicular immunomorphology both in the peripubertal period and adulthood of rats.
Material and methods. Peripubertal male rats were injected with STZ (70 mg/kg), adult rats received 60 mg/kg. Immunohistochemical staining was performed to assess cell proliferation (Ki-67), apoptosis (caspase-3), expression of androgen receptors (AR), Wilms Tumor (WT1) protein. Also, the morphology of blood vessels was analyzed on the basis of CD34-immunoreactivity. Taking into consideration the small groups of animals, statistical analysis was made with the Mann–Whitney U test.
Results. Fewer rows of proliferating spermatogonia were observed in the experimental animals (P < 0.05) of both age groups. Surprisingly, diabetes resulted in decreased caspase-3 expression (P < 0.05) except for the early period (2 weeks) in the peripubertal group, in which this trend was not observed. The same principles are true in terms of AR expression in seminiferous tubules. Hyperglycemia prevented immature testes from the complete development but thickens the walls of microvessels (P < 0.05). Also, the atrophy of spermatogenic epithelium and Sertoli cells was registered in most tubules of all the experimental groups (P < 0.05).
Conclusion. the diabetic injury of testicular tissue is a long time process possessing characteristic feature in the peripubertal period, for example, the later development of AR deficiency. In addition, the high level of apoptosis is characteristic of an immature testis and so is the tendency of caspase-immunoreactivity to persist.
Laboratory signs of carbohydrate malabsorption in early age children with rotavirus infection
Authors: Vorobiova N. V. , Usachova O. V.
Published: October 2021

The aim – to determine the laboratory manifestations of carbohydrate malabsorption syndrome in the dynamics of rotavirus infection in early age children and to identify the factors that influence its severity.
Materials and methods. The study included 60 breastfed children aged 1–24 months with rotavirus infection, who underwent pH-metry of feces, semi-quantitative determination of total carbohydrates (Benedict’s method), lactose (Malfatti method) and glucose (test systems Glucophan) in feces on the 2nd, 3rd, 5th, 7th and 10th days of the disease.
Results. Carbohydrate malabsorption syndrome was observed in 98.3% of patients. The level of fecal carbohydrates increased on the second-third day to a clinically significant 0.50 [0.20; 1,50] %, reached its maximum in the midst of the disease – from the fifth to the seventh day (0.75 [0.50; 1.65] % and 0.87 [0.40; 1.65] %, respectively), decreasing during convalescence to 0.50 [0.20; 1.50] % (P < 0.05 relative to the 10th day), but remained elevated in 81.7 % of patients (P < 0.05 relative to healthy children). Lactase deficiency and glucose malabsorption (P < 0.05 relative to healthy children) were observed throughout the RVI period. At all stages of RVI there was a strong direct correlation between the total level of carbohydrates and lactose in the feces (on the second, third, fifth, seventh and tenth days r = 0.91; r = 0.86; r = 0.91; r = 0.89, respectively). The age dependence of the severity of laboratory indicators of carbohydrate malabsorption was established. Children in the first 6 months had the highest maximum levels of carbohydrates and fecal lactose – 1.75 [1.00; 2.00] % and 3.50 [2.00; 4.00] + respectively (P < 0.05 relative to 12–24 months children) and significantly higher values of these indicators in the dynamics of RVI (P < 0.05 relative to 12–24 months children) for the second-third, fifth and the tenth day). Children with concomitant food allergies, atopic dermatitis and iron deficiency anemia had 2.0 and 1.5 times higher maximum levels of carbohydrates and lactose in the stool, respectively (P < 0.05), as well as higher values of these indicators in the dynamics of the disease – on the third and fifth days (P < 0.05).
Conclusions. The vast majority of young patients with rotavirus infection have carbohydrate malabsorption syndrome, which occurs from the first days of the disease and is most pronounced on the fifth to seventh day (P < 0.05 relative to the 10th day), realized mainly due to lactase deficiency. The most pronounced carbohydrate malabsorption syndrome and lactase deficiency in the dynamics of the disease are present in children of the first six months of life. Factors that increase the severity of carbohydrate malabsorption due to secondary lactase deficiency in the acute period of rotavirus infection are concomitant food allergies, atopic dermatitis and iron deficiency anemia.
Relationships between HBeAg status of patients with chronic hepatitis B and changes in serum TNF-α, viral load and severity of morphological changes in the liver according to non-invasive tests
Authors: Khelemendyk A. B. , Riabokon O. V. , Riabokon Yu. Yu. , Kalashnyk K. V.
Published: October 2021

Aim – to investigate the relationship between HBeAg status of patients with chronic hepatitis B and the content of TNF-α in the serum, the level of viral load and the severity of morphological changes in the liver according to non-invasive tests.
Material and methods. 70 patients with CHB were examined. Noninvasive methods were used to determine the severity of morphological changes in the liver. The content of HBV-DNA in the blood was determined by PCR, HBeAg, anti-HBe, TNF-α by ELISA. Statistical processing was performed in Statistica 13 for Windows (StatSoft Inc., No. JPZ804I382130ARCN10-J).
Results. HBeAg-negative patients (78.6 %) with anti-HBe (89.1 %) predominate among patients with CHB. Lower frequency of seroconversion in patients with stages F 2–4, compared with patients with stages F 0-1 (85.7 % vs. 100 %, P < 0.05).
The highest level of HBV-DNA in the blood was in HBeAg-positive patients, compared with HBeAg-negative with stages F 0–1 (P < 0.05), of whom 83.3 % of patients had HBV-DNA >20000 IU/ml (83.3 % vs. 17.7 %). Viral load in HBeAg-positive patients with activity A 0–1 was the highest (P < 0.05), namely 4 times more often HBV-DNA was >20000 IU/ml, compared with HBeAg-negative (P < 0.05) A 0–1.
The content of TNF-α in the serum of patients with CHB was higher than in healthy individuals (P < 0.05). The highest content of TNF-α in the blood in HBeAg-positive patients with F 2–4, compared with HBeAg-negative with F 2–4 (P < 0.05). The severity of liver fibrosis correlated with the level of TNF-α (r = 0.31, P < 0.05).
Conclusions. HBeAg-negative (78.6 %) predominate among patients with CHB. In the presence of HBeAg-positive patients F 0–1 viral load is highest (P < 0.05). HBeAg-negative patients are 2.7 times more likely (P < 0.05) to have a viral load of HBV-DNA >20000 IU/ml in the presence of A 2–3 than in A 0–1. The highest content of TNF-α is in the serum of HBeAg-positive patients with F 2–4, compared with HBeAg-negative patients and the corresponding liver fibrosis (P < 0.05).
Significance of determination of hemodynamic phenotypes in early diagnosis of cardiovascular disorders in children with diabetes mellitus
Authors: Lezhenko H. O. , Pashkova O. Ye. , Samoilyk K. V.
Published: October 2021

Aim. To stratify hemodynamic phenotypes in children with diabetes mellitus and their frequency, depending on the duration of the disease.
Materials and methods. The study involved 72 children suffering from diabetes, aged 10 to 16 years who were divided into 3 groups. The first group – 22 children with diabetes mellitus up to 1 year. The second group – 24 patients with a disease duration of 1 to 5 years. The third group – 26 children with the disease over 5 years. Control group – 20 children, representative by age and sex.
All children underwent daily blood pressure monitoring (ABPM) with the ABPM-04 device (Meditech Ltd, Hungary). Diagnosis of latent hemodynamic disorders was performed by the method of quantitative analysis of the relationships of blood pressure parameters, which involved a linear regression of systolic blood pressure by pulse blood pressure. According to the results of regression, 6 hemodynamic phenotypes were determined, which characterized the individual features of the circulatory system: harmonic, myocardial-insufficient subtype of harmonic, borderline diastolic harmonic, borderline systolic harmonic, dysfunctional diastolic and dysfunctional systolic. According to ABPM results, the ambulatory arterial stiffness index (AASI) was calculated using a linear regression equation. The results were statistically processed using statistics software package Statistica 13.0 (StatSoft Inc., No. JPZ8041382130ARCN10-J).
Results. It was found that in the dynamics of diabetes the registration of the harmonic hemodynamic phenotype during the day decreased due to an increase in the proportion of patients with dysfunctional diastolic hemodynamic phenotype. At the same time, in children with diabetes, there was a significant increase in AASI from the first year of the disease with a progressive increase with its dynamics. The highest values of AASI were observed in dysfunctional hemodynamic phenotype.
Conclusions. In children with diabetes mellitus observed the formation of disharmonious hemodynamic phenotypes in the dynamics of the disease. In combination with increased vascular stiffness these changes realized in systemic circulatory disorders and the development of a diabetic angiopathy. Detected disorders, apparently, became the risk factors of hypertension. Determination of hemodynamic phenotype in children with diabetes mellitus can be used as screening method for preclinical diagnosis of latent disorders of the cardiovascular system, early treatment and prevention.
Cluster analysis of the acute diarrhea causes in young children admitted to the infectious diseases unit
Authors: Ivanko O. H. , Bondarenko V. M.
Published: October 2021

Aim. To use the cluster analysis of clinical and laboratory data, characteristic to children aged 6 to 24 months with acute diarrhea, in demonstrating the signs of infectious or functional intestinal disorders.
Materials and methods. 56 children admitted to the children’s infectious unit with diarrhea and 31 healthy toddlers of the control group were observed. Anamnesis, laboratory blood and urine tests, microscopy and bacteriological cultures of feces on selective media and tests to identify adeno- and rotaviruses were performed. The presence of Clostridium difficile A/B toxins in the stool, hemoglobin, fecal calprotectin (FC) and the content of undigested fecal carbohydrates also were studied.
Results. Children who in their majority have received antibiotics only in 58.9 % of cases were corresponding to the bacterial or viral nature of the disease or the infection was clinically highly probable. Another 41.1 % of patients has experienced non-infectious diarrhea. In 7.1 % of all cases the diarrhea was triggered by an increase of the carbohydrate content in the stool. Diarrhea had the same mechanism in 3.4 % of patients with Giardia lamblia. In 17.9 % of patients the frequent bowel movements were the manifestation of symptomatic (parenteral) diarrhea caused by extraintestinal diseases, and in another 7.1 % the intestinal hypermotility was not explained but resembled irritable bowel syndrome in adults. Additionally, cluster analysis identified 5.4 % of patients with non-infectious diarrhea who had only significantly increased FC corresponding to allergic or immune inflammation in the gut.
Conclusions. The classification of patients for the causes of diarrhea became possible due to the microbiological tests and highly informative markers of intestinal health – fecal calprotectin and reducing substances (carbohydrates) in the stool.
The risk of development of acute kidney injury in full-term infants with administration of methylxanthines
Authors: Stryzhak L. S. , Anikin I. O. , Spakhi O. V.
Published: October 2021

Exploring new possibilities for the use of methylxanthines to prevent the development of acute kidney injury (AKI) in full-term infants with perinatal asphyxia.
Aim: to evaluate the efficacy and safety of methylxanthines in full-term infants for the prevention and conservative treatment of acute kidney injury.
Materials and methods. To test the effectiveness of the proposed method of AKI treatment, 38 infants were chosen and divided into 2 groups by random selection. Nursing and intensive care were according to current legislation (Order of the Ministry of Health of Ukraine No. 225 of March 28, 2014). The main group (n = 20) received therapy with caffeine citrate, the comparison group (n = 18) – theophylline. Both of these drugs were used to prevent the development of acute kidney injury – stage II and III according to KDIGO.
Results. A significant difference in serum creatinine was found in the main group - the level of serum creatinine was higher than in the comparison group, but did not exceed the physiological norm. GFR on the 3rd day of life was higher with administration of theophylline, but in the group of caffeine did not exceed the reference values of the norm. No differences between urea levels and diuresis rates were found in the groups. The initial results indicate the lack of statistical significance when using various drugs of the methylxanthine group, namely theophylline and caffeine citrate. This is explained by the fact that in the main group 65.00 % (n = 13) of patients had AKI stage 0 according to KDIGO, and 35.00 % (n = 7) had stage I. In the comparison group, 55.56 % (n = 10) and 44.44 % (n = 8), respectively. Stages II and III in both groups of the study did not develop, the obtained data are equivalent – U = 163,00; P = 0,6296. However, the use of caffeine citrate may become a priority due to a better safety profile compared to theophylline. Caffeine is less likely to cause adverse effects in the form of non-pathological bile vomiting and has significantly lower relative risk of non-pathological bile vomiting in infants (RR 0.26 (95 % CI 0.10; 0.66)).
Conclusions. Conservative methylxanthine therapy in full-term infants with perinatal asphyxia prevents the development of stages II and III of AKI according to KDIGO. However, it is necessary to continue the collection of material to increase the statistical significance, as well as to study the early and long-term consequences of this therapy.
The role of myeloperoxidase as a diagnostic and prognostic factor in cardiovascular pathology (acute coronary syndrome)
Authors: Kopytsia M. P. , Rodionova Yu. V. , Tytarenko N. V. , Kutia I. M. , Нilоva Ya. V.
Published: October 2021

Myeloperoxidase is one of the key enzymes involved in oxidative stress and inflammation. Its elevated levels are determined in a wide range of both acute and chronic forms of cardiovascular diseases. The inflammation results in the release of the enzyme from the white blood cells to form products such as hypochlorous acid, which in turn can have a negative effect on the target proteins. Inconsistent evidence on the predictive role of this biomarker in diseases of the circulatory system generates scientific interest and provokes further research in this direction.
The aim of this review is to analyze the scientific literature data on myeloperoxidase as a possible clinical use for the diagnosis and risk stratification of patients with саrdiovascular diseases.
Materials and methods. Searching and generalization of data from leading specialized sources, which are indexed by scientific databases PubMed, SCOPUS, Web of Science.
Results. The results of the studies indicate that myeloperoxidase is actively involved in the pathophysiology of cardiovascular diseases through participation in oxidative stress and inflammation, excessive production of proatherogenic lipoproteins, changes in nitric oxide activity, endothelial dysfunction, and due to the effect on the instability of atherosclerotic plaques. In patients with cardiovascular diseases, including ischemic heart disease, the concentration of the indicated protein is increased and is often associated with a poor prognosis, including an increased risk of mortality. Myeloperoxidase metabolites are often the factors that contribute to cell damage under conditions of ischemia. The review also considers the relationship of the enzyme with the development of restenosis and the effectiveness of revascularization after percutaneous coronary intervention.
Conclusions. The presented data mainly define myeloperoxidase as a significant marker for predicting long-term follow-up results and the development of serious adverse cardiovascular events, mortality in patients with cardiovascular disease. At the same time, despite the great achievements in disclosing the complex effects of myeloperoxidase, inconsistency in the available results is noteworthy. This controversy necessitates further research to elucidate and reveal the full clinical potential of myeloperoxidase in patients with cardiovascular pathology.
Morphological features of histogenic differon cells in connective tissue of guinea pigs’ lungs after sensitization with ovalbumin
Authors: Popko S. S. , Yevtushenko V. M.
Published: October 2021

An urgent issue of modern morphology is establishing a number of patterns of morphological changes and reactivity of connective tissue components of lungs in case of experimental sensitization with allergens.
The aim is to estimate morphological features of histogenic differon cells in connective tissue of guinea pigs’ lungs after sensitization with ovalbumin.
Materials and methods. Using morphometric and histological method, we have estimated the lung connective tissue of 48 male guinea pigs with experimental ovalbumin-induced allergic inflammation, simulated by subcutaneous sensitization and aeroallergization with ovalbumin. The number of fibrocytes, fibroblasts per 5000 μm2 and their ratio – fibroblast/fibrocyte coefficient were determined.
Results. We have established the regularity of morphological changes dynamics in the cellular elements of pulmonary connective tissue. Experimental sensitization and inhalated allergization with ovalbumin leads to a statistically significant increase in the average number of fibroblasts and fibrocytes throughout the observation period in all experimental groups. It has been proved that the dynamics of cells has a multidirectional character, demonstrated by indicators of the fibroblast/fibrocyte coefficient, which shows the disproportion in the fibroblast/fibrocyte ratio and proves the tendency to the development of fibrosis in guinea pigs’ pulmonary connective tissue in case of experimental sensitization with ovalbumin.
Conclusions. A gradual increase in the number of fibrocytes, against the background of a decrease in the number of fibroblasts is observed from the 23rd day to the completion of experimental sensitization with ovalbumin in the lungs of guinea pigs, compared with control group. A decrease of fibroblast/fibrocyte coefficient from 1.37 ± 0.03 in the early period to 0.82 ± 0.03 in the late period of the allergic inflammation demonstrates multidirectional nature of the dynamics in the number of connective tissue cells and indicates a tendency towards the development of fibrosis in pulmonary connective tissue.
Distance learning technologies at the postgraduate stage of professional development of pharmacists
Authors: Avramenko M. O. , Tkachenko N. O. , Riabokon Yu. Yu. , Bigdan O. A.
Published: October 2021

Today, pharmaceutical education has to respond flexibly, dynamically and adequately to social transformations by developing new educational services, teaching technologies and organizing the training process. In response to the demand of the time, postgraduate professional education strives to meet the current needs; a new concept of increasing the effectiveness of education and the professional level of specialists has been formed: lifelong learning is impossible without the use of information and communication technologies.
The aim of the work is to identify the features of the organization of the training process of pharmaceutical professionals at the postgraduate stage at Zaporizhzhia State Medical University (ZSMU) and to outline its problematic issues with further identification of possible ways of improvement in the context of continuing professional development (CPD).
Materials and methods. The study was grounded on the experience of organizing the training of pharmaceutical interns, students of advanced training cycles at the Faculty of Postgraduate Education of ZSMU for the last 10 years, reporting and other accounting documents, regulations on higher pharmaceutical education at various levels. The methods of analysis and synthesis, grouping, deduction, logic and generalization are used in the work.
Results. The postgraduate phase of СPD of pharmaceutical specialists is aimed at improving professional competencies and allows the specialist to maintain or improve the standards of professional activity in accordance with the needs of health care.
Training of pharmaceutical specialists at the Faculty of Postgraduate Education is practiced both face-to-face and distantly, using distance learning technologies in a specialized web environment, grounding on modern psychological, pedagogical and information and communication technologies (basic is Microsoft Office 365 and others). This format of education stimulates students to unleash their potential, increase the level of self-organization and self-management, deepens professional competencies by improving the communication component.
The management of ZSMU, driven by social responsibility, constantly works on improving the quality of educational services, including those of the postgraduate stage.
Conclusions. According to the results of critical analysis of the experience of training pharmaceutical interns and students of advanced training cycles at FPE of ZSMU for the last 10 years, reporting and regulatory documentation, features of the educational process of pharmaceutical specialists at the postgraduate stage are identified, its problematic issues are outlined and ways to solve them in the context of СPD are deteermined.
Some aspects of analysis of the Ukrainian legislation regulating the production of veterinary medicines
Authors: Bushuieva I. V. , Petrova K. V. , Polova Zh. M.
Published: October 2021

The aim of the work was to study the current state of domestic legislation of state regulation in the field of licensing the activities of business entities manufacturing veterinary medicinal products and its harmonization with the requirements of the European Union.
Materials and methods. The research materials were regulatory and legislative acts, regulations and principles of the state policy of Ukraine connected with licensing the activities of business entities manufacturing veterinary medicinal products, in force from 2015 to the present. To carry out this study, the methods of information retrieval, systematization, analytics, graphic, comparison, and data generalization were used.
Results. The article presents the main results of the analysis of the Ukrainian legislation which regulates the production of veterinary medicines and preparations. According to the results of the analysis, it was found that in the period from 2015 to 2018, Ukrainian manufacturers of veterinary medicinal products worked in such conditions that did not require a license for this type of activity. By the decree of the President of Ukraine, the program of sustainable strategic development of the country “Ukraine-2020” was approved which provided for reforms in the format of deregulation and the development of entrepreneurship and excluded the necessity of licenses for veterinary drugs production.
Conclusions. Based on the study, it can be concluded that the Law of Ukraine “On Licensing of Types of Economic Activities” dated March 3, 2015 No. 222-VIII was actually aimed at reducing the governmental influence and regulatory pressure on the activities of business entities involved in the production of veterinary medicinal preparations.
Civil liability in pharmacy
Authors: Aleksieiev O. H.
Published: October 2021

The aim to characterize civil liability as a component of legal liability in pharmacy.
Materials and methods. During the research, the methods of analysis, synthesis, and legal comparison were used. National civil legislation, as well as general theoretical approaches and points of view to the issues of civil liability in the pharmaceutical healthcare sector were used as research material.
Results. The sphere of circulation of medicines is a multifaceted complex of legal relations regulated by the norms of various branches of law. At the same time, their generalizing feature is the focus on providing the population with affordable, safe and high-quality medicines. Establishing the rights of citizens at the legislative level, the legislator always necessarily provides for mechanisms of protection against violation of these rights. One of the most effective mechanisms is legal liability. Since the above citizens' rights are civil rights, it seems relevant to investigate the essence and content of civil liability in the pharmaceutical healthcare sector. Pacta sunt servanda is a principle of international law, according to which treaties are binding and must be executed in good faith. Unlike contractual liability, delict liability occurs in cases where the violator does not have a contractual relationship with the offended party.
Conclusions. Civil liability is one of the most effective measures to ensure the constitutional right of citizens to accessible. safe and quality medicines. Determination of the legal status of a pharmaceutical worker as one of the central figures in healthcare is necessary for the correct determination of the type of civil liability
Studying Depression, Anxiety, Distress and Somatization in a Community Sample of 2,425 Adults in Greece
Authors: Louvardi Maya , Pelekasis Panagiotis , Bacopoulou Flora , Vlachakis Dimitrios , Chrousos George , Darviri Christina
Published: October 2021

A growing part of the literature has focused on depression, anxiety, distress and somatization. Identifying their prevalence and recording high-risk populations is essential in order to form relevant interventional programs addressing these symptoms. The aim of this study was to examine the prevalence and associated factors of distress, depression, anxiety and somatization in a community adult sample in Greece. Participants were recruited from two Greek cities; Giannitsa in the northern area and Athens in the southern area of the country and  completed sociodemographic assessments, as well as the 4-Dimensional Symptom Questionnaire (4-DSQ), a self-reported instrument assessing depression, anxiety, distress and somatization.A total of 2,425 adults, females (60.1%) and males (39.9%), 18 to 84 years of age (mean age 46.98 ± SD) participated in the study. Mental health symptoms were reported by 10.8% for depression, 12% for anxiety, 13% for distress and 5.3% for somatization of the participants. Females scored higher than males in anxiety, distress, and somatization (p=0.000 in all cases), while there were no significant sex differences in depression (p=0.593). Statistically significant associations were found between age and depression, anxiety and distress (p=0.000 in all cases), since those between 18-34 years of age had higher scores than the older age groups in all variables. Higher scores of depression, anxiety and distress were reported by students and unemployed participants (p=0.000 in all cases) than participants with other occupations. This study mapped several sociodemographic groups with worse mental health. Studies in representative population samples are needed to guide public health interventions to improve the mental and physical well-being of high-risk populations.
Sustainability certification and legality verification in Indonesian natural forest-based wood products value chains
Authors: Susilawati D. , Kanowski P.J.
Published: October 2021

Indonesian natural forest concessions and value chains are governed by a mandatory Timber Legality Verification System (SVLK), which includes assessment of Sustainable Production Forest Management (PHPL). Concessionaires and processors may also pursue voluntary forest certification.
This study explores actors' compliance with these instruments along wood product value chains originating primarily from natural forests. Empirical results demonstrate that SVLK fostered legality compliance in domestic as well as export value chains, but still allows some possible loopholes.
It is easier for actors to comply with SVLK than with Forest Stewardship Council (FSC) certification, because SVLK has less stringent requirements, and uses an assessment system that allows poor field performance and does not foster continuous improvement of practices. These results identify
weaknesses in the architecture and implementation of the regulatory instruments, and suggest measures to strengthen Indonesia's sustainable forest management and timber legality systems.
Randomised Control Trial of 3 IU Intravenous Oxytocin Bolus With 7 IU Oxytocin Infusion Versus 10 IU Intramuscular Oxytocin in the Third Stage of Labour in the Prevention of Postpartum Hemorrhage
Authors: Biradar Aruna M , Yaliwal Rajasri G , Kori Shreedevi S , Mathapati Sangamesh S , Shiragur Shobha S , Mudanur Subhashchandra R
Published: October 2021

Objectives: Intravenous (IV) oxytocin during vaginal delivery has been rarely used since an intramuscular (IM) route or IV infusion have been preferred in this regard. The trial aimed to compare the low-dose IV bolus 3 IU of oxytocin, along with 7 IU oxytocin infusion with 10 IU oxytocin infusion in cesarean section. Materials and Methods: A parallel control randomized study was conducted on a total of 320 consenting term pregnant women based on the inclusion criteria. The participants were randomized into either 3 IU IV bolus and 7 IU infusion of oxytocin or 10 IU of IM oxytocin following vaginal delivery. The difference in pre- and post-delivery hemoglobin (Hb) levels, tone of the uterus, hemodynamic changes, adverse effects of the drug, and the need for additional uterotonics and blood transfusions were assessed based on the aim of the study. Results: Based on the results, more women with severe blood loss were found in the IM oxytocin group in comparison to the IV bolus with infusion group following vaginal delivery. In addition, more women had a drop in the Hb of 3 gm/dL in the IM oxytocin group compared to the IV bolus-infusion group (11% vs. 4%, odds ratio=0.768, P=0.469) although there was no statistical significance in this respect. The tone of the uterus was firmer in the IV bolus with infusion group at 3 and 5 minutes. Eventually, the difference in hemodynamic changes, side effects, and the need for additional uterotonics or blood transfusions was not significant. Conclusions: In general, an IV bolus of 3 IU with a 7 IU infusion of oxytocin is as safe as and more effective than the IM injection of 10 IU of oxytocin at the time of vaginal delivery for the prevention of postpartum hemorrhage.
Comparison of Menstrual Effluent Vascular Endothelial Growth Factor Immunocytochemistry Expression Between Endometriosis and Non-Endometriosis Patients
Authors: Anwar Ruswana , Sunardi Sunardi , Salima Siti , Irianti Setyorini , Purwara Benny Hasan , Djuwantono Tono , Permadi Wiryawan , Madjid Tita Husnitawati
Published: October 2021

Objectives: This study aimed to measure the vascular endothelial growth factor (VEGF) expression in menstrual effluent from patients with endometriosis compared to non-endometriosis through immunocytochemical methods. We also measured the degree of pain level, endometrioma cyst size, and infertility status whether it is affected by VEGF expression. Materials and Methods: The present case-control study was conducted in Hasan Sadikin General Hospital, Bandung. Thirty productive-age women diagnosed with endometrioma and 30 productive-age women without endometriosis as the control group were included in this study. Menstrual effluent was taken from the posterior fornix on the second day of menstruation and stained using immunocytochemistry staining for VEGF. Results: The results demonstrated a significant difference between the two study groups in terms of VEGF intensity and histoscore although no difference was found in VEGF distributions between the study groups. The subjects in the endometriosis group had significantly higher VEGF intensity and significantly higher VEGF histoscore compared to the control group. Women with VEGF histoscore more than 6 has 9.33 times risk of developing endometriosis compared to those with lower histoscore. There were no significant correlations between VEGF and pain scale, infertility, and the cyst size. Finally, the cyst size was proportionally related to pain. Conclusions: VEGF distribution and expression in endometriosis women were significantly higher than VEGF levels in non-endometriosis women. Women with menstrual effluent containing higher VEGF levels had more chances of developing endometriosis compared to those with lower VEGF levels. Eventually, larger endometrioma size was proportionally related to higher pain levels in subjects with endometrioma.
Radical Hysterectomy With and Without Neoadjuvant Chemotherapy in Patients With Cervical Cancer Stage IB-IIB
Authors: Mostafa Gharabaghi Parvin , Bakhshandeh Saraskanrood Masumeh , Sayyahmelli Manizheh , Jafari Mehri , Saheb Olad Madarek Elahe , Vaezi Maryam , Rahmani Vahideh , Adili Ali , Ebrahimpour Malahat , Amidfar Atie , Pourbargi Maryam
Published: October 2021

Objectives: In this study, radical hysterectomy, followed by neoadjuvant chemotherapy (NACT) in patients with locally advanced cervical cancer (LACC) was compared with radical hysterectomy in patients with early-stage cervical cancer. Material and Methods: This retrospective comparative observational study was performed on 13 patients with LACC International Federation of Gynecology and Obstetrics (FIGO) stage IB2-IIB who underwent a radical hysterectomy after NACT between March 2014 and November 2018. This group was compared with 18 patients undergoing radical hysterectomy with cervical cancer FIGO stage IIA-IB1 in the same period of time. Results: In the NACT group, 8 (61.5%) and 5 (38.4%) patients were in stages IIB and IB2, respectively, and 13 (72.2%) cases were in the IB1 stage in the non-NACT group. Post-operative blood transfusion in the NACT group was significantly higher compared to the non-NACT group [5 (38.4%) patients versus 0, P = 0.008]. The estimated blood loss (EBL) and operative time were similar between the groups. Finally, there were no significant differences in terms of intra-operative and other post-operative complications. Conclusions: Radical hysterectomy after NACT in women with LACC seems to be safe and reduces the need for radiation in patients with NACT who are at stage IIB. These results need to be confirmed in studies with a larger patient sample.
Healing House I: A Material Phenomenology of Illness
Authors: Stahl Darian Goldin
Published: October 2021

This paper is a deep investigation into one art installation, Healing House I, which materializes the lived experience of being diagnosed with a chronic illness. This artwork is part of a collaborative project between artist Darian Goldin Stahl and her sister, Devan Stahl, who was diagnosed with multiple sclerosis. Together, they use a phenomenological methodology to express the disconnections between the lived body and the body object that can occur after a diagnosis, as well as the conditions necessary to mend this separation. Joining fleshy material, sound, vibration, and scent in this artwork, Goldin Stahl analyses how a multi-sensory and artistic interpretation of her sister’s illness narratives can tacitly communicate one experience of living with MS. In sharing this artwork with others in a disability arts exhibition, the sisters aim towards fostering a collective, intercorporeal understanding and empathy for the ill body.
Embodiment, Autoethnography, Performance Poetry:  Living with Severe Traumatic Brain Injury
Authors: Kidd Douglas E.
Published: October 2021

This presentation offers neurodivergence embodied, autoethnography, and performance poetry. The confluence of acquiring severe traumatic brain injury combined with exposure to concepts and paradigms while pursuing a graduate degree in Disability Studies, catalyzed emergence and triggered development of my disabled identity. The brain damage acquired causes issues of decoding/deciphering/processing, which in turn triggers and/or produces episodes of temporal dissonance. When these shifts in timing occur, they have tremendous impact on rational thought processes and emotional stability. The salient aspects of my new life – emotional sensitivity and volatility – may on the surface seem detrimental and undesirable; however, I celebrate these qualities as they greatly enhance my identification with and empathy for others, which in turn drive my artistic, social, cultural, political expression, quest for community and belonging. While temporal dissonance is unlikely to occur during this planned short presentation, I will relate and provide the audience with windows on largely hidden and little understood forms of impairment.

 

Note: To hear recitation of some of these poems, check out fellow VIBE presenter Cheryl Green’s podcast: http://whoamitostopit.com/pigeonhole-podcast-17-autoethnographic-poetry/

 

The original presentation at VIBE was accompanied by music from Miles Davis and Marcus Miller’s 1987 album Music from Siesta. Readers are encouraged to listen to this album via their music platform of choice while reading the following poetry. Youtube link to the album: https://www.youtube.com/watch?v=ZuvtNL_jyeQ
Raising the Bar in Disability Arts
Authors: Nagrani Menka
Published: October 2021

This article discusses my pedagogical approach towards teaching dance, movement, and theatre to artists with cognitive disabilities. I have developed a training method for artists participating in my classes and productions that invites individual creative exploration and professional rigour. My inclusive dance-theatre company, Les Productions des pieds des mains, creates productions that are presented on professional artistic platforms and not limited to the context of disabled art presentations. Our productions are regularly subject to the same selection criteria as would be a non-inclusive company. With this in mind, I aim for excellence. I work towards creating high quality shows while helping artists with a disability push past their perceived limits and surpass themselves. In this article I will share my findings and strategies, perfected throughout my many years of experimentation, explaining  how to reach a high-level of quality in inclusive productions, as well as how I help artists with a disability reach a level of quality in their performances which allows them to find gainful employment within the artistic domain.
A Podcast with Paul Tshuma – Musician/Composer/Producer (Transcript)
Authors: Tshuma Paul , McAskill Ash , Thulin Samuel
Published: October 2021

Montreal-based musician, composer, and music producer Paul Tshuma talks about his career and his musical process with special issue editors Ash McAskill and Samuel Thulin. Tshuma was one of the two opening keynote speakers for the VIBE symposium. Tshuma edited the audio interview/podcast included in this issue of the CJDS. The transcript of the interview, conducted on 8 April 2019, is included here.
…and this is my voice: autopathophonography and the politics of variable voice
Authors: Sterne Jonathan
Published: October 2021

This essay describes the production and theoretical context of an audio work entitled “…and this is my voice.” In May and June 2010, I took recordings of my voice while on the way into external beam radiation treatments for an aggressive case of papillary thyroid cancer in my neck. I then used these recordings as the raw material for the work. This essay provides full documentation of the production process for those who may want or need something beyond the original audio work to engage with it fully, as well as a theoretical discussion of the ideology of vocal ability: the belief that voices are expressions of subjects’ inner states and abilities.

 

Work available at: https://jonathansterne.bandcamp.com/track/and-this-is-my-voice
Presenting: Michael Nimbley
Authors: Nimbley Michael , Bourgeois Catherine
Published: October 2021

The following is the working script from Montreal-based artist Michael Nimbley’s presentation about his professional career. The script was co-created with his creative ally Catherine Bourgeois, the founder and artistic director of Montreal-based theatre group, Joe Jack & John. Joe Jack & John is a theatre company that produces original, bilingual, multidisciplinary shows combining video, dance, and the spoken word. Their artistic approach is deeply humanistic and inclusive; their creations represent a social microcosm by integrating professional actors with an intellectual disability or from diverse cultural backgrounds. During the time of VIBE, Nimbley was an artist-in-residence with the company. In establishing artistic residencies, Joe Jack & John are fulfilling their mission in a new way by inviting an artist living with a disability to initiate and direct a creation of their own. These residencies demonstrate a unique political stance. By handing power to an artist with an intellectual disability, they are furthering their research on marginalized aesthetics and voices. Their goal is to develop interdependent creative models and practices, promoting the emergence of underrepresented voices that have not been part of the dominant artistic trends. In doing so, they are disrupting aesthetic hierarchies and continuing to dismantle biases against artists who evolve outside the artistic establishment.
Program Racjonalnej Terapii Przeciwgrzybiczej „WYLECZ!”
Authors: Styczyński Jan , Dzierżanowska-Fangrat Katarzyna , Matysiak Michał , Kałwak Krzysztof , Irga-Jaworska Ninena , Szczepański Tomasz
Published: October 2021

Epidemiologia inwazyjnej choroby grzybiczej (IFD) dowodzi rosnącego udziału szczepów opornych, dotyczącego wszystkich klas leków. Odpowiedź na leczenie zależy od wielu czynników, z których część jest modyfikowalna. Takim czynnikiem jest stosowanie zasad racjonalnej terapii przeciwgrzybiczej (zasady zarządzania środkami przeciwgrzybiczymi, AFS). Jest to strategia wprowadzona analogicznie do procesu stosowania zasad racjonalnej terapii przeciwdrobnoustrojowej (zarządzania środkami przeciwdrobnoustrojowymi, AMS). AFS w kontekście ogólnych AMS wyrażone jest w praktyce stosowaniem czynników, określonych jako 6D: diagnosis, debridement/drainage, drug, dose, deescalation, duration. Koncepcja zwracania uwagi na racjonalność działań i unikanie błędów występujących w codziennej praktyce klinicznej ma już swoją historię w medycynie, z początkiem w Stanach Zjednoczonych w 2012 roku w postaci kampanii „Choosing Wisely” („Wybierz mądrze”). Pomimo rozwoju możliwości profilaktyki, diagnostyki i terapii, problem inwazyjnych zakażeń grzybiczych utrzymuje się od wielu lat. W maju 2021 roku, podczas X Zjazdu Polskiego Towarzystwa Onkologii i Hematologii Dziecięcej (PTOHD), pod patronatem PTOHD został ogłoszony Program Racjonalnej Terapii Przeciwgrzybiczej. Cztery główne cele programu to: racjonalne stosowanie leków przeciwgrzybiczych, ograniczenie rosnącej oporności grzybów na leki przeciwgrzybicze, unikanie błędów występujących w praktyce klinicznej oraz edukacja personelu medycznego, pacjentów i rodzin. Koncepcja Programu Racjonalnej Terapii Przeciwgrzybiczej jest oparta na 6 zasadach określonych akronimem WYLECZ!: właściwe rozpoznanie, wyczyszczenie chorego miejsca, lek, efektywna dawka, czas trwania leczenia, zakończenie i podsumowanie terapii.