bluuebunny/crossref_metadata_2025 huggingface dataset:
Heyingwuzi formulation alleviates diabetic retinopathy by promoting mitophagy via the HIF-1α/BNIP3/NIX axis
Authors: Wu Jia-Jun , Zhang Shu-Yan , Mu Lin , Dong Zhi-Guo , Zhang Yin-Jian
Published: June 2024

BACKGROUND

Diabetic retinopathy (DR) is the primary cause of visual problems in patients with diabetes. The Heyingwuzi formulation (HYWZF) is effective against DR.

AIM

To determine the HYWZF prevention mechanisms, especially those underlying mitophagy.

METHODS

Human retinal capillary endothelial cells (HRCECs) were treated with high glucose (hg), HYWZF serum, PX-478, or Mdivi-1 in vitro . Then, cell counting kit-8, transwell, and tube formation assays were used to evaluate HRCEC proliferation, invasion, and tube formation, respectively. Transmission electron microscopy was used to assess mitochondrial morphology, and Western blotting was used to determine the protein levels. Flow cytometry was used to assess cell apoptosis, reactive oxygen species (ROS) production, and mitochondrial membrane potential. Moreover, C57BL/6 mice were established in vivo using streptozotocin and treated with HYWZF for four weeks. Blood glucose levels and body weight were monitored continuously. Changes in retinal characteristics were evaluated using hematoxylin and eosin, tar violet, and periodic acid-Schiff staining. Protein levels in retinal tissues were determined via Western blotting, immunohistochemistry, and immunostaining.

RESULTS

HYWZF inhibited excessive ROS production, apoptosis, tube formation, and invasion in hg-induced HRCECs via mitochondrial autophagy in vitro . It increased the mRNA expression levels of BCL2-interacting protein 3 (BNIP3 ), FUN14 domain-containing 1, BNIP3-like (BNIP3L , also known as NIX ), PARKIN , PTEN-induced kinase 1, and hypoxia-inducible factor (HIF )-1α . Moreover, it downregulated the protein levels of vascular endothelial cell growth factor and increased the light chain 3-II/I ratio. However, PX-478 and Mdivi-1 reversed these effects. Additionally, PX-478 and Mdivi-1 rescued the effects of HYWZF by decreasing oxidative stress and apoptosis and increasing mitophagy. HYWZF intervention improved the symptoms of diabetes, tissue damage, number of acellular capillaries, and oxidative stress in vivo . Furthermore, in vivo experiments confirmed the results of in vitro experiments.

CONCLUSION

HYWZF alleviated DR and associated damage by promoting mitophagy via the HIF-1α/BNIP3/NIX axis.
Effects of exercise training on glucose metabolism indicators and inflammatory markers in obese children and adolescents: A meta-analysis
Authors: Li Le-Yang , Li Song-Mei , Pang Bo-Xian , Wei Jun-Ping , Wang Qiu-Hong
Published: June 2024

BACKGROUND

Obesity in children and adolescents is a serious problem, and the efficacy of exercise therapy for these patients is controversial.

AIM

To assess the efficacy of exercise training on overweight and obese children based on glucose metabolism indicators and inflammatory markers.

METHODS

The PubMed, Web of Science, and Embase databases were searched for randomized controlled trials related to exercise training and obese children until October 2023. The meta-analysis was conducted using RevMan 5.3 software to evaluate the efficacy of exercise therapy on glucose metabolism indicators and inflammatory markers in obese children.

RESULTS

In total, 1010 patients from 28 studies were included. Exercise therapy reduced the levels of fasting blood glucose (FBG) [standardized mean difference (SMD): -0.78; 95% confidence interval (CI): -1.24 to -0.32, P = 0.0008], fasting insulin (FINS) (SMD: -1.55; 95%CI: -2.12 to -0.98, P < 0.00001), homeostatic model assessment for insulin resistance (HOMA-IR) (SMD: -1.58; 95%CI: -2.20 to -0.97, P < 0.00001), interleukin-6 (IL-6) (SMD: -1.31; 95%CI: -2.07 to -0.55, P = 0.0007), C-reactive protein (CRP) (SMD: -0.64; 95%CI: -1.21 to -0.08, P = 0.03), and leptin (SMD: -3.43; 95%CI: -5.82 to -1.05, P = 0.005) in overweight and obese children. Exercise training increased adiponectin levels (SMD: 1.24; 95%CI: 0.30 to 2.18, P = 0.01) but did not improve tumor necrosis factor-alpha (TNF-α) levels (SMD: -0.80; 95%CI: -1.77 to 0.18, P = 0.11).

CONCLUSION

In summary, exercise therapy improves glucose metabolism by reducing levels of FBG, FINS, HOMA-IR, as well as improves inflammatory status by reducing levels of IL-6, CRP, leptin, and increasing levels of adiponectin in overweight and obese children. There was no statistically significant effect between exercise training and levels of TNF-α. Additional long-term trials should be conducted to explore this therapeutic perspective and confirm these results.
Reconsidering the role of depression and common psychiatric disorders as partners in the type 2 diabetes epidemic
Authors: Claro Angelo Emilio , Palanza Clelia , Mazza Marianna , Rizzi Alessandro , Corsello Andrea , Tartaglione Linda , Marano Giuseppe , Schuenemann Giovanna Elsa Ute Muti , Rigoni Marta , Pontecorvi Alfredo , Janiri Luigi , Muti Paola , Pitocco Dario
Published: June 2024

Common psychiatric disorders (CPDs) and depression contribute significantly to the global epidemic of type 2 diabetes (T2D). We postulated a possible pathophysiological mechanism that through Bridge-Symptoms present in depression and CPDs, promotes the establishment of emotional eating, activation of the reward system, onset of overweight and obesity and, ultimately the increased risk of developing T2D. The plausibility of the proposed pathophysiological mechanism is supported by the mechanism of action of drugs such as naltrexone-bupropion currently approved for the treatment of both obesity/overweight with T2D and as separate active pharmaceutical ingredients in drug addiction, but also from initial evidence that is emerging regarding glucagon-like peptide 1 receptor agonists that appear to be effective in the treatment of drug addiction. We hope that our hypothesis may be useful in interpreting the higher prevalence of CPDs and depression in patients with T2D compared with the general population and may help refine the integrated psychiatric-diabetic therapy approach to improve the treatment and or remission of T2D.
Numerical Investigation of Combustion Characteristics in a Binary
Fuel Blend of C
8
H
18
and H
2
Authors: Almansour Bader
Published: June 2024

The escalating energy demand in today’s world has amplified exhaust emissions,
contributing significantly to climate change. One viable solution to mitigate
carbon dioxide emissions is the utilization of hydrogen alongside gasoline in
internal combustion engines. In pursuit of this objective, combustion
characteristics of iso-octane/hydrogen/air mixtures are numerically investigated
to determine the impact of hydrogen enrichment. Simulations are conducted at 400
K over a wide range of equivalence ratio 0.7 ≤ Ф ≤ 1.4 and pressure 1–10 atm.
Adiabatic flame temperature, thermal diffusivity, laminar burning velocity, and
chemical participation are assessed by varying hydrogen concentration from 0 to
90% of fuel molar fraction. As a result of changes in thermal properties and
chemical participation, it is noticed that the laminar burning velocity (LBV)
increases with higher hydrogen concentration and decreases as pressure
increases. Chemical participation and mass diffusion were found to be the main
contributors to the LBV increase in binary fuel blends. To circumvent
NOX formation, a binary fuel blend at Ф = 0.7 and 80%
H2 is selected to increase combustion intensity while maintaining
a relatively low flame temperature and retaining 85% of energy density by
volume. It is noted that the concentration of H, O, and OH radicals increase
with hydrogen enrichment. Furthermore, the analysis revealed that the LBV
increases linearly with the peak mole fraction of radicals. Key reactions are
identified through sensitivity analysis and net reaction rates. A significant
increase in net reaction rate is observed for H2 + O <=> H + OH
and H2 + OH <=> H + H2O, which in turn increases the
pool of radicals. This is evident by the increase in the net production rate of
H, O, and OH radicals.
A Comprehensive Survey of Foot-Operated Steering Systems for Individuals with Upper Limb Disabilities: A Literature Review
Authors: Soundararajan R. , Babu N. , Ashoka Vardhanan P. , Shijo Joseph C.S.
Published: June 2024

A significant portion of the global population about 13.6% of the world's population faces challenges due to upper limb disabilities caused by accidents, genetics, health issues or aging. These people struggle with everyday mobility tasks and often need help. Hence, the research is focused on creating special vehicle control systems to help them. This study gathers knowledge from various science and technology fields to develop foot-operated steering systems letting those with upper limb differences control vehicles with their feet. The research explores various technologies like modified steering, brain-controlled vehicles, foot-operated steering, steer-by-wire and Ackermann steering. Most of these systems are custom-made for people with upper limb differences. Ensuring safety, security, malfunction prevention, precise steering, user-friendliness and affordability is a significant challenge that demands advanced technology. Furthermore, there is a requirement to develop this system to meet modern demands while sustaining cost-effectiveness. In the pursuit of addressing the mobility challenges encountered by individuals with upper limb differences the research undertook a thorough assessment of various steering mechanisms such as Disk Steering, Joystick Steering, Push Button Steering…etc. The proposal introduces a foot-operated press button system to replace hand-operated steering wheels. Drivers can steer with their feet by engaging a press button on the steering pad. It connects directly to a controller which interfaces with a motor connected to a pinion pin. This motor moves the wheels precisely responding to the driver's interaction with the foot-operated press button and it is seamlessly connecting with steer-by-wire technology ensuring precise and responsive steering. whether they are using custom made vehicles or regular vehicles equipped with our proposed mechanism.
Aluminum Alloy Sheet, Alclad, 5.7Zn - 2.2Mg - 1.6Cu - 0.22Cr (7475-T61), Solution and Precipitation Heat Treated
Authors:   AMS D Nonferrous Alloys Committee
Published: June 2024

This specification covers an aluminum alloy in the form of sheet 0.040 to 0.249 inches (1.02 to 6.32 mm), inclusive, in nominal thickness (see 8.5).
Removal of contaminants of emerging concern by membranes in water and wastewater: An updated review
Authors: Kim Siye , Jun Byung-Moon , Jung Bongyeon , Park Chang Min , Jang Min , Nam Seong-Nam , Yoon Yeomin
Published: June 2024

The current review covers removal of contaminants of emerging concern by membranes in water and wastewater since our much cited review in 2018. This review offers a wide-ranging examination of membrane technologies—in particular, forward osmosis, reverse osmosis, nanofiltration, ultrafiltration, and microfiltration—as potent solutions that can be used to target contaminants of emerging concern (CECs) in water and wastewater treatment. Emphasizing the urgency of preserving water quality amid increasing demand and CEC-related concerns, the current paper underscores the critical need to obtain a more holistic understanding of the impacts of CEC, effective strategies for their removal, and essential regulatory measures. The interplay between membrane properties, operating conditions, and contaminants underscores the importance of tailored membrane designs and optimization in achieving efficient CEC removal. The main purpose of this review was to synthesize the existing knowledge on membrane treatment of CECs and highlight future research directions. This review not only synthesizes the recent advancements that have been achieved but also highlights critical research avenues, including advanced surface modifications, novel materials, optimized operational parameters, and sustainability considerations. Achieving future strides in these areas would likely enhance the efficacy and sustainability of membrane technologies in combatting CECs in water systems.
GELENEKSEL UYGUR EVLERİNİN YAPISAL ÖZELLİKLERİ VE DIŞ MEKÂN TASARIMI
Authors: Özçalık Mahire
Published: June 2024

İnsanların yaşantıları ile sahip olduğu teknolojik imkânları ve sosyo-kültürel çevre, toplumun geçmiş yaşantıları hakkında önemli ipuçları verir ve geleceğin kültürel yapılanması ile ilgili önemli yol gösterici görevleri üstlenir. Türklerin mimari sanatının tarihi uzun, şekli kendine özgü ve anlam yüklü olup mimarisi tarihî medeni miraslarının önemli bir kısmını teşkil etmektedir. Türkler binlerce yıllık kültürel değerlerinden sağladıkları zengin birikimlerini bulundukları topraklarda yaşatmaya çalışmıştır. Girdikleri toplumda zamanla kültür etkileşimi ile yeni bir kültür sentezinin ortaya çıkmasına sebep olmuştur. Çin’in Sincang Uygur Özerk Bölgesi’ndeki (Doğu Türkistan) tarım havzası Uygur-Türk kültürüne sahne olmuştur. Uygur bölgesi dünyanın en önemli kültür merkezlerinin kavuşma noktasında bulunmasından dolayı devamlı bir kültür alışverişine ortam hazırlamıştır. Geleneksel Uygur evleri Doğu Türkistan’ın iklimsel ve topografik yapısının yanı sıra kültürel dinamiklere göre şekillenen çevresel ve kültürel unsurları içerisinde barındıran, dünya konut mimarisi bakımından özgün, estetik açıdan güzel ve konforlu olmanın yanı sıra tarihsel bir derinliğe sahiptir. Geleneksel Uygur evinin dış mekân tasarımına ait analiz bulguları değerlendirildiğinde, farklı işlevlerin gerçekleşmesini sağlayan mekân kurgusu, iç mekân şekillenmesinde uygulanan detaylar bakımından geleneksel konutun ihtişamının ve her detayında doğa ile bağlantısının net bir şekilde kendini gösterdiği görülmektedir. Uygur konutları kültürel mirasın ürünü olmalarının yanı sıra geleneksel konut tarihinin ve dış mekân düzenleme özelliklerinin oluşturulduğu mekânlardır. Bu doğrultuda bu çalışma, hem ataların yaşam felsefesinin yansıtılması yönünden hem de gelecek nesillere kendi zengin kültürlerini tanıtma bakımından önemli bir misyona sahiptir. Bu gibi konuların araştırılması, tanıtılması, uygulanması gelecek nesillere aktarılması açısından önem arz etmektedir. Bu çalışmanın amacı, geleneksel Uygur evlerinin yapısal özelliklerini ve dış mekân tasarım geleneklerini ortaya koymaktır. Bu doğrultuda çalışmada, zengin kültüre sahip, karakteristik bir nitelik taşıyan geleneksel Uygur evinin yapısal özellikleri, mekânsal durumu, özgün değerleri, işlevsel oluşumları, iç ve dış mekân tasarım bileşenleri, peyzaj değerleri, estetik zenginlikleri gibi konular irdelenerek hızla yok edilmeye çalışılan tarihî kültürel mirasın ortaya konulması amaçlanmıştır.
Şükran Oğuz, Uygur Tarihi Koşakları Üzerine Bir Araştırma, Çanakkale: Paradigma Akademi, 2023, 563 s.
Authors: Yavuz Münevver
Published: June 2024

Manisa Celal Bayar Üniversitesi Eğitim Fakültesinde görev yapmakta olan Dr. Şükran OĞUZ tarafından kaleme alınan “Uygur Tarihi Koşakları Üzerine Bir Araştırma” adlı eser, tarihi ipek yolu üzerinde varlığını sürdürerek günümüze kadar gelmiş, zengin sözlü ve yazılı kültür geleneğine sahip Doğu Türkistan topraklarında yaşayan Uygur Türklerinin tarihi koşaklarını konu almaktadır. Uygur tarihi koşakları; Uygur halk şiiri içerisinde konusunu Uygur tarihinden ve bu tarihi devirlerde yaşamış olan önemli şahsiyetlerden alan kendine has söyleyiş şekli olan halk şiirleridir. Çalışmada konu edilen tarihi koşaklar, foklorist Uçukcan Ömer tarafından sözlü gelenekte derlenerek yazıya geçirilen ve Şincañ Universiteti Neşriyati (Ürümçi) tarafından 2009 yılında yayımlanan ‘Uyğur Xelq Tarixiy Qoşaqliri Qamusi” (Uygur Halk Tarihi Koşakları Kamusu) adlı eserden elde edilmiştir. Hazırlanan bu eser Şükran Oğuz’un aynı isimli doktora tezinin kitaplaştırılmasından oluşmaktadır.
Çalışmanın “Giriş”, “Sonuç”, “Kaynaklar”, “Özgeçmiş” ve “Dizin” haricinde beş bölümü bulunmaktadır. Eserin “Giriş” kısmında Uygur adı üzerinde durularak Uygur Türklerinin yaşadığı Doğu Türkistan bölgesi hakkında genel bilgi verilmiştir. Ayrıca Uygur Türklerinin siyasi Tarihi; “Hocalar Dönemi (1678-1755)”, “Çin Mançu (Ǫing hanedanı) Dönemi (1755-1911), Milliyetçi Çin Cumhuriyeti Dönemi (1 Ocak 1912-1944), Üç Vilayet İnkılabı Dönemi (1944-1 Ekim 1949), Komünist Çin Halk Cumhuriyeti Dönemi olmak üzere beş döneme ayrılarak kısaca açıklanmış ve araştırmanın konusu, amacı, yöntemi, sınırlılıkları hakkında bilgi verilmiştir.
Ömer Nazar, Uygur Tababetinde Diyabet Hastalıkları Hakkında İlk Araştırmalar ve Tedavileri, Ankara: Nobel Yayıncılık, 2023, 101 s.
Authors: Aktı Seçil
Published: June 2024

Türk milleti geçmişten günümüze varlığını sürdürdüğü farklı coğrafyalarda meydana getirdiği kültürel birikimler ışığında birçok çalışmaya konu olmuştur. Bu çalışmalar incelendiğinde Türkler hakkında tarih sahnesine ilk çıktıkları günden bugüne, konargöçer/göçer evli yaşam sürdükleri Orta Asya kültüründen yerleşik yaşama geçiş aşamalarına, farklı coğrafyaların yanı sıra Anadolu coğrafyasında devam eden varlıklarına kadar pek çok araştırma yapılmıştır. Türkler bu varlıklarını sürdürme noktasında yaşadıkları coğrafyaların koşulları ya da irsî olarak nitelendirilen kalıtım yoluyla geçen aile mirası, pek çok hastalık için hastalığı önleme ve hastalığın ortaya çıkması sonucunda da kendi tedavi yöntemlerini oluşturmuşlardır.
Türk kültüründe diyabet hastalıklarının tespiti ve tedavisi hususunda Prof. Dr. M. Ömer Nazar’ın “Uygur Tababetinde Diyabet Hastalıkları Hakkında İlk Araştırmalar ve Tedavileri” adlı kitabıyla yaptığı katkı, diyabet hastalığı konusunda yapılan çalışmalara nadide bir örnek teşkil etmektedir. Urumçi Uygur Eğitim Hastanesi Eski Başhekimi Prof. Dr. M. Ömer Nazar tarafından yazılan, 2023 yılında edebiyat ve tıp dünyasına kazandırılan ve Nobel Akademik Yayıncılık tarafından yayınlanan eser “Takdim”, “Kaynakça” ve “Biyografi” dışında 10 ana bölümden oluşmaktadır.
Nazar, “Takdim” kısmında kronik bir hastalık olarak nitelendirdiği diyabetus hastalığı hakkındaki bu kitabını yazma amacından bahsetmiştir. Kitabında Batı tıp kavramlarının yerine geleneksel tıp ve Uygur tıbbının kavramlarını kullanmıştır. Ayrıca Urumçi Uygur Tababeti Eğitim ve Araştırma Hastanesi İç Hastalıkları Bölümünde yapmış olduğu poliklinik araştırmalarının sonucuna Arabistan ve Türkiye’deki çalışmalarını da ilave ederek bu kitabı Türk halkına armağan ettiğini açıklamıştır.
PHARMACEUTICO-ANALYTICAL STUDY OF HERBAL FACE SHEET MASK – A PREEMINENT PREPARATION.
Authors: Patel M Spandana , B Markande Geetha , Padyana Subrahmanya
Published: June 2024

Ayurveda places significant emphasis on the role of Agni in achieving optimal health, including a radiant complexion. Literature of Ayurveda, while enlisting the benefits of Abhyanga and detoxification therapies, focused on
the enhancement of the complexion along with optimising the digestive fire. The demand for modernisation encourages us to adopt fewer advancements, keeping the baselines of Ayurveda to cope with time and comfort. Face
sheet masks are an advanced preparation that can be used irrespective of time and place. Hence, an effort was
made to prepare and analyse a face sheet mask of herbal origin to facilitate a good complexion using Ventilago
maderaspatana Gaertn (dineshavalli) oil. Analytical and microbial Studies have shown encouraging results.
A CASE REPORT ON THE MANAGEMENT OF SULCUS VOCALIS WITH REFER-ENCE TO SWARASADA
Authors: V J Aswathy , V R Subin , A Binitha
Published: June 2024

1Sulcus vocalis is a condition characterized by a groove or infolding of the mucosa along the surface of the vocal
fold, disrupting the normal physiology of vocal fold vibration and impacting voice production. Common symptoms include hoarseness, vocal fatigue, voice weakness, and increased effort, particularly concerning working
professionals who rely on speech for communication and quality of life. While treatment options like phono surgery and speech therapy exist, phono surgery often yields disappointing results, typically limited to increased
voice loudness. In Ayurveda, this condition aligns with Swarasada, attributed to factors such as 2Athyucha bhasana(loud speaking) and abhighata(trauma), leading to dosha invasion in sabdhavahi siras and causing speech
difficulties.
Presented here is a case report involving a 33-year-old IT professional experiencing hoarseness, vocal fatigue, and
weakness. Upon bronchoscopy, the diagnosis initially indicated muscle tension dysphonia, later revealing bilateral
sulcus vocalis with GERD. The patient underwent Nasya, Gandusha, and Sneha Sweda procedures alongside internal medication. Following a one-month review, the patient exhibited marked improvement in voice clarity. Notably, modern treatments provided only temporary relief. This case report underscores the effective management
of sulcus vocalis through Panchakarma treatments and internal medications, showcasing consistent relief over a
three-month review period.
CASE SERIES ON EFFICACY OF VAPU SPRAY IN EPISIOTOMY WOUND
Authors: - Maneesha , Asokan Vasudevan , Subrahmanya Padyana
Published: June 2024

BACKGROUND: A surgically planned incision on the perineum and the posterior vaginal wall during the second stage of labour is called episiotomy (perineotomy). In Ayurveda Samhita, the description of an episiotomy
wound has not been given directly, but Vrana(wound) is described very well, and an episiotomy wound can be
considered Yoni Vrana. In the present era, there are several methods for managing episiotomy wounds, such as
NSAIDs, antibiotics, etc. Still, it is found to have various adverse effects like inflammation, itching, peptic ulcer,
delayed wound healing and drug resistance. Hence, the prime focus is proper care and treatment to promote episiotomy wound healing and avoid complications. AIM- To evaluate the preventive and therapeutic efficacy of
VAPU Spray on perineal wound healing after episiotomy. OBJECTIVE- To analyse the effect of VAPU spray
in managing episiotomy wounds. MATERIALS AND METHODS- The study was conducted among a few postnatal patients with Right mediolateral episiotomy (RMLE), and four such subject evaluations are presented here.
RESULTS: These patients were successfully treated with VAPU Spray, which contains Panchavalkala, Triphala,
etc., and has Vrana Shodhana and Vrana Ropana qualities. The result was assessed by using the REEDA Scale
and VAS scale. The considerable results were pain, oedema, discharge, redness, and tenderness in episiotomy
wounds. CONCLUSION- Thus, we can conclude from the study that this Ayurveda regimen with a modified
drug delivery system was influential in managing episiotomy wounds
GARBHINI PARICHARYA W.S.R TO MASANUMASIKA PARICHARYA
ACCORDING TO VARIOUS AUTHORS
Authors: Himasree Enjeti , Vijaya Kumari Kola
Published: June 2024

Ahara plays a crucial role in the maintainence of health of a woman throughout different stages of her life and given more important role during their Growth , Pregnancy , Lactation and Menopause . In women’s life , Sagarbhavastha ( pregnancy ) is the most important stage and pregnant woman should treat with specific care . According to Ayurveda , Ahara is considered to be the best source of nourishment as well as medication for Garbhini . Garbhini Paricharya refers to care of Garbhini in aspects of Ahara , Vihara , Yoga & Pranayama etc.,, to attain Paripurnatva ( proper growth of fetus & mother ) , Anupaghata ( non-complicated pregnancy ) & Sukha prasava ( normal delievery ) and to prevent any further adverse effects / complications to both . Garbhini Paricharya describes Masanumasika Paricharya , Garbhopaghatakara bhavas , Garbha sthapaka dravyas .,, by which they have direct effect on the health of mother & Child . So , in this article we have given importance to Masanumasika Paricharya of Garbhini according to various Acharya’s and should be discussed in detail .
A CASE REPORT ON RAKTA PRADARA
Authors: Jashmi G. , Santha Kumari R. Vijaya
Published: June 2024

Rakta pradara is one of the common gynaecological complaints seen in our OPDs—Pradirana (Excessive se-cretion) of Raja, termed as Pradara by Acharya Charaka1. Prolonged and intermenstrual bleeding is termed Asrigdara by Acharya Susrutha2. The menstrual bleeding flowing abnormally in volume, duration, intensity, and frequency is called the disease Raktapradara (AUB). Various treatment modalities like hormonal therapy, anti-prostaglandins, antifibrinolytic agents and surgical interventions are available in modern medicine for the man-agement of AUB. Considering the side effects and adverse effects, Ayurvedic management can be recommended as a safer, more feasible and more effective therapy for the management of Rakta pradara.
Effect of Selenium Yeast Tablets Combined with Levothyroxine Sodium on Thyroid Function and Inflammatory Factors in Patients with Hypothyroidism
Authors:   Department Endocrinology , Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen, Guangdong Province, 518107, China, Xin Yuan-Yuan
Published: June 2024

Objective To investigate the clinical efficacy of selenium yeast tablets combined with levothyroxine sodium in the treatment of hypothyroidism and its effect on thyroid function and inflammatory factors. Methods 110 patients with primary hypothyroidism admitted to The first Affiliated Hospital of Yangtze University from January 2018 to December 2018, and were randomly divided into the observation group (55 cases) and the control group (55 cases). The patients of the control group were given sodium levothyroxine, while the observation group received selenium yeast tablets combined with levothyroxine sodium therapy. The indexes of thyroid function/clinical efficacy/adverse events were compared between the two groups. Results The total effective rate of the observation group was 92.73%, and 72.73% in the control group, there was a significant difference between the two groups (P<0.05). After treatment, T3, T4, FT3 and FT4 levels were significantly increased compared with that before treatment the differences were statistically significant (P<0.05). And TSH, TGAb and TPOAb levels were significantly lower compared with that before treatment, and the difference were statistically significant (P<0.05). After treatment, T3, T4, FT3 and FT4 degree of observation group were better than those of the control group, the differences were statistically significant (P<0.05). After treatment, the levels of IL-12 and IFN-γ in both groups decreased, but the levels of IL-12 and IFN-γ the observation group were lower than those in the control group (P<0.05). After treatment, the level of IL-10 increased in two groups, but the level of IL-10 in the observation group was higher than that of the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion The selenium yeast tablets combined with levothyroxine sodium in treatment of hypothyroidism can obtain obvious theraeputtic effects. which can not only improve the levels of various thyroid indexes, but also can improve patient's inflammatory factors levels, with good safety, without serious adverse reactions, therefor, which has important clinical application value. Key words: Selenium; Yeast Tablet; Hypothyroidism; Inflammatory Factor.
MODERN SERVICES MARKET
Authors:   The Institute of Serbian Culture Priština – Leposavić, Serbia, Antonović Ratomir
Published: June 2024

The starting premise of this paper is the fact that today services and the service sector represent the main factor of the modern economy. The service sector is rapidly developing and growing, with a constant tendency of growth and development. A special branch of the economy is developing, the so-called service economy, with significant implications for economic growth and development and the constitution of economic policy. With the development of the service economy, there is also the growth and development of the service society, and the service society is the same as the modern society, because service activities represent the essence of the modern way of life. Also, service law should be mentioned here, as a new legal branch that studies services, as a completely heterogeneous type of activity. The paper specifically studies certain market laws, which contribute to the growth and development of the service sector, along with the presentation of statistical data, which may be of importance for this research. Also, attention will be paid to market competition, market competition and the problem of unfair competition
THE CONCEPT OF (D)E-MATERIALIZATION IN E-COMMERCE
Authors:   Faculty of Law, ", Kamboski Igor ,   Goce Delčev",   University of Štip, North Macedonia
Published: June 2024

The contemporary dynamics of trade flows in the conditions of market globalization, digitalization of society and hyper-inflation of technological achievements have imposed changes in traditional understandings of trade, but also in the legal regulation of trade relations, and even in the redefinition of some of the basic terms and elements of civil and commercial law. The need and goal to speed up sales, to realize international transactions and payments, was achieved by electronic contract signing. It is no longer necessary to send a contract by e-mail, print it, sign it and then send it again by classic or e-mail. The electronic contract signature, integrated into the contracting process, enables secure, fast and simple signing. Advantages brought by e- materialization (synonymous with dematerialization, but in a digital environment): the contract is signed immediately, remotely, without the use of paper, and the contract is automatically archived in the user's file, that is, with the contracting parties. Dematerialization, i.e. e-materialization of contracts is a process that is gaining more and more importance in companies, public organizations, as well as merchants, as part of their digital transformation. However, two conditions must be met in order for these contracts to be legally valid and binding: clearly confirmed authenticity of the signatory of the contract, and a guarantee for the authenticity and integrity of the document. The subject of purchase and sale in electronic commerce and electronic contracts are more often dematerialized things, which do not have a material- physical form and which can be delivered online, via the Internet. Acquiring, and therefore realizing and proving ownership rights to these things also represents a challenge for modern legal science and practice.
Effects of Stock Trading Volume, Leverage, and Dividend Payout Ratio on Stock Price Volatility
Authors: Kartawijaya Alvin Maximillian , Hasibuan Henny Triyana
Published: June 2024

This study aims to analyze the impact of stock trading volume, leverage, and dividend payout ratio (DPR) on stock price volatility among companies included in the Kompas100 Index and listed on the Indonesia Stock Exchange (IDX) from 2018 to 2022. The data used in this research were obtained from the financial statements available on the official IDX website and additional data from Yahoo Finance. A purposive sampling method was used to select the research sample based on specific criteria. The results of the study indicate that stock trading volume and leverage have a significant positive impact on stock price volatility, while DPR also influences volatility by showing changes that can elicit sharp market reactions. These findings provide important insights for investors and company management regarding factors that can increase risk and uncertainty in stock prices in the market.
Sistem Pemesanan dan Pembayaran Makanan berbasis Web Terintegrasi dengan Application Programming Interface (API)
Authors: Bororing Grace Martha Geertruida , Gunawan Ferry
Published: June 2024

The era of digitalization makes technology inseparable from human life, such as business people. Business technology in the culinary field such as restaurants, some of which have implemented a food ordering system in the form of digital menus, but still need to queue at the cashier or wait for the waiter to come to take orders. One way to make it easier is to implement a website-based food ordering system where customers can order and pay for their orders directly. The use of this payment method will take advantage of the services of the Xendit API (Application Programming Interface). The technology will be implemented into a web-based application using the Codeigniter framework. This research was conducted using an agile method with a qualitative approach. The research results obtained will be in the form of a web-based application with ordering and payment features that can be done at once. The resulting application is expected to assist cashiers in processing payments, as well as beneficial for customers and business owners because it reduces operational costs.
DYNAMICS OF DEFORMATION FORCES IN SINGLE-PARTICLE SPECTRA OF ODD 2s1d-SHELL NUCLEI
Authors: Korda V.Yu. , Korda L.P. , Klepikov V.F. , Timchenko I.S.
Published: June 2024

With help of our newly-developed evolutionary model-independent approach we have found that with the increase in mass number of all studied odd 2s1d-shell nuclei 23Na, 27Al, 31P, and 35,37Cl the dominant deformation of the shape of these nuclei in low-laying single-particle states changes from quadrupole to hexadecapole and further to hexacontatetrapole. The single states and the continuous sets of states with abnormally weak deformation are found. The points of shape phase transitions with a change in the multipolity of deformation are found in the single-particle spectrum of 37Cl nucleus.
CROSS-SECTIONS OF PHOTONEUTRON REACTION natMo(γ,xn)93mMo AT THE BREMSSTRAHLUNG ENERGY UP TO 95 MeV
Authors: Timchenko I.S. , Deiev O.S. , Olejnik S.M. , Potin S.M. , Kushnir V.A. , Mytrochenko V.V. , Perezhogin S.A.
Published: June 2024

The photoproduction of the 93mMo nucleus on natural molybdenum was studied using the electron beam of the LUE-40 linac RDC “Accelerator” NSC KIPT. Measurements were performed using the activation method and off-line γ-ray spectrometric technique. For the natMo(γ,xn)93mMo reaction the experimental flux-averaged cross-sectionϭ(Eγmax)m at the bremsstrahlung end-point energy range of 38…93 MeV was first time determined. The theoretical values of the yields Ym,g(Eγmax) and flux-averaged cross-sections(Eγmax)m,g for the natMo(γ,xn)93m,gMo reactions were calculated using the cross-sections ϭ(Eγ) from the TALYS1.96 code for different gamma strength functions and level density models. The comparison showed strong discrepancies between the experimental values and the theoretical results of (Eγmax)m.
INVESTIGATION OF THE PARTIAL CHANNEL OF 8Be NUCLEUS GROUND STATE FORMATION IN THE 14N(γ,2α6Li) REACTION
Authors: Afanasiev S.N. , Afanasieva I.O.
Published: June 2024

Using the track 4𝜋-detector method (a diffusion chamber arranged in a magnetic field on the way of a beam of bremsstrahlung photons with the final energy 𝐸𝛾max = 150 MeV), the reaction 14N(γ,2α6Li) has been studied. The distributions of events over the excitation energy of 2𝛼-particles were analyzed and a channel of the formation of the 8Be nucleus in the ground state was revealed and has been separated. Events in which the 𝛼-particle pairs correspond to the formation of the 8Be nucleus in the ground state can be reliably identified. The energy and angular distributions of 𝛼 particles at each stage of decay are analyzed.
A autocontenção estrutural do Poder Judiciário. Legitimidade, capacidade e Tema 698 do STF
Authors: Mascarenhas Caio Gama
Published: June 2024

O objetivo deste artigo é, inicialmente, debater as teorias por trás dos parâmetros objetivos para a intervenção do Poder Judiciário em políticas públicas na decisão do Supremo Tribunal Federal quando do julgamento do RE 684.612 (Tema 698). O texto inicia tecendo breves comentários sobre legitimidade processual interna do Poder Judiciário (legitimidade democrática e legitimidade constitucional), para então abordar a sua legitimidade externa de resultados (teoria das capacidades institucionais) e seus desdobramentos. Por fim, aborda-se a teoria da decisão estrutural. Defende-se, ao final do artigo, que há uma correlação lógica entre a teoria da decisão estrutural e a teoria das capacidades institucionais – razão suficiente para acreditar em uma “autocontenção estrutural” do Poder Judiciário. O Supremo Tribunal Federal não demonstra sinais de timidez no tocante às possibilidades de intervenção do Poder Judiciário, porquanto considera que este ramo de poder está exercendo legitimamente suas atribuições enquanto guardião da constituição. O mesmo argumento não pode ser dito, no entanto, em relação à forma de sua intervenção. Argumenta-se que a adoção do processo estrutural e da decisão estrutural enquanto linguagem do Poder Judiciário seja um reconhecimento (explícito ou implícito) da ausência de capacidade institucional para concretizar direitos fundamentais de forma sistêmica. Daí o motivo para acreditar em uma autocontenção estrutural por parte do Poder Judiciário nesses casos. Por se tratar de um estudo descritivo e exploratório, é realizado com base na pesquisa bibliográfica e documental, utilizando-se por vezes do método dedutivo e, outras vezes, do indutivo, principalmente nas críticas e reflexões acerca da doutrina, estudos e textos normativos.
O Federalismo brasileiro da emergência: o (re)arranjo das relações entre os entes federativos nacionais no contexto da pandemia da Covid-19, à luz da jurisprudência do Supremo Tribunal Federal
Authors: Lima Cesar Henrique Ferreira
Published: June 2024

O presente artigo tem por objetivo central tratar do cenário de (re)arranjo do federalismo brasileiro, tendo por foco as relações travadas entre a União e os entes federativos subnacionais (i.e., estados e municípios brasileiros) no contexto da pandemia do vírus causador da Covid-19 e o papel do Supremo Tribunal Federal na aludida conjuntura emergencial. A hipótese principal deste texto é a de que, à luz do modus operandi adotado pela Administração Pública federal no enfrentamento à pandemia da Covid-19, sob a liderança do então Presidente da República, Jair Messias Bolsonaro, o federalismo brasileiro passou por um processo de rearranjo, vis-à-vis o seu histórico de centralismo na figura da União (representado pela ideia de federalismo brasileiro de carne e osso). As principais marcas desse processo de reacomodação – em que o Supremo Tribunal Federal desempenhou o papel de relevante agente catalisador, o que pode ser observado em um conjunto de decisões proferidas pela Corte Constitucional entre os anos de 2020 e de 2021, objeto de análise neste trabalho – foram a intensificação da descentralização de poderes e o fortalecimento dos entes federativos subnacionais (estados e municípios), com vistas a viabilizar a adoção e/ou a preservação de medidas legislativas e administrativas em prol da contenção da disseminação do vírus causador da Covid-19.
Electronic Communication Strategies of the Ministry of Heritage and Tourism to Promote the Sultanate of Oman
Authors: Ben Lagha Faten , Abdullah Almamari Jalila
Published: June 2024

This study aims to identify the communication strategies used by the Ministry of Heritage and Tourism to promote the Sultanate of Oman as a tourist destination electronically, as well as the extent of employing electronic communication activities to support these strategies, in line with the premises and objectives of the Tourism Strategy 2040. The study relied on the media survey methodology to achieve its objectives and answer its questions using several tools: observation, document and data analysis, and content analysis.
The results of the study concluded that the Ministry of Heritage and Tourism uses several communication strategies to promote the Sultanate of Oman electronically as a tourist destination, which are push strategy, pull strategy, cognitive strategy, emotional strategy, persuasion strategy, information strategy, dialogue strategy, consensus-building strategy, and relationship-building strategy. The study results also indicated that the Ministry of Heritage and Tourism has a diversified electronic communication activity, focusing more on websites and social media.
The study confirmed that the (Experience Oman) account tweets daily during the study sample period, and the ministry uses images in most of the study sample’s tweets. Additionally, 74٪ of the tweets are not content created by the Ministry of Heritage and Tourism but instead sharing of the content of others. The study showed that interaction with the account’s posts is modest.
Finally, the study recommends developing electronic communication activities, virtual reality technologies, and artificial intelligence, optimizing search engines, and focusing on storytelling content. The study also recommends updating the social media strategy in line with modern trends in the media content industry.

Keywords: Communication strategies, electronic communication activities, Promotion, Ministry of Heritage and Tourism, Sultanate of Oman.
Studi Pustaka dalam Efektivitas Pemanfaatan Perpustakaan Sekolah untuk Meningkatkan Minat Baca Siswa di Sekolah Dasar
Authors: Desiana Della Nathalia , Putri Karina Trisna , Metravia Monika , Marini Arita
Published: June 2024

Penelitian ini bertujuan untuk mengetahui seberapa efektif penggunaan perpustakaan sekolah untuk meningkatkan minat baca siswa di sekolah dasar. Penelitian ini menggunakan pendekatan kualitatif dengan pendekatan deskriptif. Melalui studi pustaka, data dikumpulkan dan dianalisis secara deskriptif dan analitis untuk memahami fenomena dan variabel yang mempengaruhi minat baca siswa. Hasil penelitian menunjukkan bahwa pemanfaatan perpustakaan sekolah secara efektif dapat meningkatkan minat baca siswa, yang ditunjukkan dengan peningkatan jumlah buku yang dibaca siswa dan frekuensi kunjungan mereka ke perpustakaan, serta tersedianya buku-buku yang menarik dan fasilitas perpustakaan yang memadai.
Knowledge, Attitude, and Practices (KAP) in Complementary and Alternative Medicine (CAM) Among Selected Asian Countries: A Literature Review
Authors:   Surigao del Norte State University Philippines, L. Elicano Ma Leea
Published: June 2024

This literature review examines the landscape of Complementary and Alternative Medicine (CAM) in selected Asian countries, focusing on knowledge, attitudes, and practices (KAP) among healthcare professionals and the general population. Drawing insights from studies conducted in Bangladesh, Iran, Malaysia, Thailand, Nepal, Oman, Pakistan, Saudi Arabia, and the Philippines, the review highlights the increasing interest in CAM as a holistic approach to health and well-being. While positive attitudes towards CAM are prevalent, challenges such as knowledge gaps, concerns about evidence, and limited integration into clinical care persist. The review underscores the importance of education, research, and policy interventions to promote the safe and effective use of CAM, enhance healthcare quality, and meet the diverse healthcare needs of populations in the region. Recommendations include investing in educational programs, supporting research initiatives, and raising public awareness to advance healthcare systems’ capacity in integrating CAM practices effectively.
Reform of College English Teaching Content in Engineering Colleges against the Background of New Engineering Education
Authors:   Beijing Institute of Petrochemical Technology, Guo Ziyu , Li Boming ,   Beijing Institute of Petrochemical Technology, Ge Shan ,   Beijing Institute of Petrochemical Technology, Cao Kexin ,   Beijing Institute of Petrochemical Technology, Hua Yaojie ,   Beijing Institute of Petrochemical Technology
Published: June 2024

In recent years, increasing attention has been paid to the development of new engineering education. College English, a compulsory course aimed at non-English majors in China’s universities, bears great responsibilities in training high-quality innovative engineering talent with an international perspective. After an examination of the current College English teaching content and an analysis of college students’ needs for English learning, the paper proposes three ways to reform the teaching content of College English in light of nurturing new engineering talent: integrating language and cultural knowledge with subject-specific knowledge, enhancing students’ ability of applying English in their professional domains, and emphasizing both humanistic education and professional competence in College English teaching.
Pupils’ Focus and Motivations: Their Influence on Mathematics Performance
Authors:   Southern de Oro Philippines College, Cagayan de Oro City, Philippines, Wheeler, Resa S. , Cabigas Marie Emerald A. ,   Southern de Oro Philippines College, Cagayan de Oro City, Philippines
Published: June 2024

Motivation and focus are vital for academic success, particularly in Mathematics, as evidenced in this study, which explores the relationship between pupils' focus and motivation and Mathematics performance. This study examined the correlation between focus, motivation, and Mathematics performance among three hundred fourteen (314) Grade 6 pupils in the West 1 District of Cagayan de Oro City during the School Year 2023–2024.The focus of the study was measured using a previously established questionnaire by Fredricks et al. (2011) and Ersoy (2015). This approach ensured a reliable and well-tested method for gauging pupil focus. A descriptive correlational and causal research design was used. Statistical treatments used are mean, SD, and correlational relationships to analyze the data. Findings revealed that the pupils are extrinsically motivated and perform satisfactorily in Mathematics. Motivation significantly influences academic outcomes, including focus and performance. Motivation that significantly predicts performance in Mathematics, as evidenced by a regression coefficient. Stimulating and fulfilling pupil motivation and satisfaction is fundamental to promoting successful learning and academic performance. Hence, focusing on techniques like mindfulness, minimizing distractions, promoting sustained concentration, improving pupils' ability to stay focused, and potentially enhancing academic outcomes in Mathematics is recommended.
Humanistic Buddhism: Amṛtyupasthāna, Ānāpānasmṛti and Holistic Health Management
Authors:   Fo Guang University, Taiwan, Lu Lung-Tan
Published: June 2024

Humanistic Buddhism provides a profound and unique perspective on exploring the path of holistic health. Smṛtyupasthāna (Four Mindfulnesses) is a basic meditation method in Buddhism, which involves continuous awareness and observation of four different aspects: (1) Kāyānupassanā (Body Mindfulness), (2) Vedanānupassanā (Mindfulness of Feelings), (3) Cittānupassanā (Mindfulness of Mind) and (4) Dhammānupassanā (Mindfulness of Dharma). Mindfulness is an effective way to manage worries, allowing us to be free from worries, stay away from upside-down dreams, and achieve a state of freedom. This article proposes a model of humanistic Buddhism and holistic health: (1) Kāyānupassanā and Physical Well-being, (2) Vedanānupassanā and Spiritual Well-being, (3) Cittānupassanā and Mental Well-being, and (4) Dhammānupassanā and Social Well-being. The Four Mindfulness Practices of Humanistic Buddhism provide us with valuable tools and ways to improve the holistic health and cope with the challenges and difficulties in life. Through spiritual practice and practice, we can achieve holistic health at the individual, physical, spiritual and social levels.