bluuebunny/crossref_metadata_2025 huggingface dataset:
Research on interrelations between mental burnout and factor signs of teachers’ professional self-fulfillment
Authors:   Kaliningrad Regional “Institute of Education Development”, Sviderskaya Svetlana P. , Shabasheva Evgenia A. ,   Immanuel Kant Baltic Federal University, Ignatovich Yulia O. ,   Immanuel Kant Baltic Federal University
Published: May 2023

Introduction. Despite the fact that the modern teacher needs to have certain professional qualities and a high level of professional competence, there is a problem of uncertainty of many factors and their impact on the processes of teachers’ professional development. The influence of a number of factors on the psychological health of teachers, as well as their emotional burnout is of particular interest. However, research devoted to the factors of teachers' professional self-fulfillment that influence emotional burnout is still insufficient. In this regard, the aim of our research was to find interrelations between professional self-fulfillment and emotional burnout of teachers. Materials and methods. The link of these factors with emotional burnout of teachers was tested empirically on a sample of N=70, using questionnaires "Diagnostics of professional burnout according to K. Maslach and S. Jackson adapted by N.E. Vodopyanova" and the author's "Diagnostics of pedagogical self-fulfillment" by S. P. Sviderskaya. Factor analysis (principal components method) and paired correlation analysis (Pearson and Spearman correlation coefficients) were used as data processing methods. Results. The factors of teachers' professional self-fulfillment that showed vivid negative correlations with the indicators of emotional burnout were revealed: job satisfaction (r=-0,576, p=0,003), activity, initiative (r=-0,633, p=0,002), belief in professional success (r=-0,538, p=0,010), cooperation with colleagues (r=-0,528, p=0,012), self-education (r=-0,539, p=0,010), desire for self-fulfillment (r=-0,540, p=0,009; r=-0,554, p=0,005). These factors were accepted as prognostically valid in relation to prevention of teachers’ emotional burnout. They were distributed into the following groups of factors: "Teaching skill", "Activity", "Self-development". Conclusion. The study of interrelations between self-fulfillment indicators and emotional burnout of teachers has proved the importance of in-depth research of professional self-fulfillment. It also confirmed the necessity of self-fulfillment, the purpose of which, among other things, is prevention of teachers’ emotional burnout syndrome. Keywords: teacher, burnout, professional self-fulfillment, signs of self-fulfillment, factors of self-fulfillment, research activity, mental health of the teacher
Parenting and Family Relationships Factors in the Intergenerational Transmission of Partnerships: a Research Review
Authors:   Moscow Institute of Psychoanalysis, Shmakova Albina I.
Published: May 2023

Introduction. Partner behavior can be transmitted among generations. Factors influencing the intergenerational transmission of partnerships can include parenting and relations in the parental family. Currently, there is a discrepancy between the increasing need for psychological practice to understand intergenerational transmission of partnerships and the level of prior studies of the problem. The purpose of the article is to provide an analytical review of modern scientific research on the link between parents' and their children's relationships in adolescence and adulthood. Materials and methods. The methodological basis of the review is the concept of intergenerational transmission by A.A. Schutzenberger, N. Abraham, M. Terek and others, as well as Bowen's family systems and transgenerational approach. The method of literature analysis on the issues of factors of intergenerational transmission of patterns of partnering was used in the work. The search engines for scientific research Google Scholar, eLibrary.ru, CyberLeninka, etc. were used. Results. The review identified factors that are related to children's partnering in adolescence and adulthood. A secure attachment and a safe family environment were particularly important for building relationships, in contrast to the factor of divorce itself. Parental conflicts and styles of their resolution, the type of attachment were associated with the parenting. The mother's depression affects the psychological well-being of the child and, as a consequence, the building of his or her relationship with the partner. Conclusion. Within the problem of intergenerational transmission of patterns of romantic and marital relationships, the relationship between young people and parental conflicts, the number of breakups and divorces in the parental family, the quality of the mother's relationship with her partner, and the quality of the relationship with the child in childhood all matter. Thus, the article determines which factors of family upbringing and relationships between parents influence the building of children’s partnerships in the next generation. It is emphasized that there is a lack of Russian studies on this topic, even though it is very important for the well-being of marital relations to identify intergenerational factors that affect them. Keywords: intergenerational transmission, marriage, partnerships, family
The great educator of the Middle Volga peoples of Russia N. I. Ilminsky
Authors:   Vyatka State University, Pomelov Vladimir B.
Published: May 2023

Introduction. Enlightenment is an important part of the history of education. Imperishable examples of outstanding enlightenment figures serve as an example for new generations of teachers. The purpose of the article is to comprehensively reveal the activities and personality characteristics of the great Russian educator of non-Russian peoples of the second half of the XIX century, Nikolai Ivanovich Ilminsky (1822-1891/1892). Materials and methods. The leading research methods are the analysis of scientific and periodical literature, biographical and historical methods, as well as a regional and axiological approaches, which make it possible to identify the most valuable in the subject of research within a certain administrative and geographical framework. Results. Ilminsky occupies a special place in the history of education of non-Russian, primarily Middle Volga, peoples of Russia. He developed and put into practice the work of many schools for children of "small" peoples, a special education system named after him, the main components of which were teaching non-Russian children first in their native language with a gradual transition to Russian, the opening of national schools, the training of teachers from among the Middle Volga peoples and the publication of appropriate methodological literature. Discussion. Ilminsky's axiological and methodological views received a different, sometimes diametrically opposed assessment in the decades following his death. His pedagogical heritage is actively used in modern Russia, primarily in multiethnic regions. 2022 marks the 200th anniversary of his birth. Conclusion. The methodological legacy of Ilminsky needs further study for practical application in modern conditions of reforming the national school system. The personality of the great educator and internationalist can serve as an axiological model and example for the younger generation of Russian youth. Keywords: The Russian Empire, the enlightenment of non-Russian peoples, the Brotherhood in the name of St. Gurius, Ilminsky, Timofeev
Uji Daya Hambat Tepung Tanaman Kenikir (Cosmos caudatus kunth) terhadap Bakteri Salmonella Sp, Escherichia coli Serta Evaluasi Senyawa Zat Aktif Flavonoid, Polifenol dan Saponin
Authors: Pasi Maria Selfiana , Djunaidi Irfan H. , Natsir M. Halim
Published: May 2023

Penelitian ini bertujuan untuk mengetahui sampai sejauh mana bagian - bagian tanaman kenikir memiliki daya hambat bakteri salmonella sp, escherichia coli dan mengevaluasi senyawa aktif flavonoid, polifenol dan saponin yang berpotensi sebagai feed additive. Penelitian ini telah di lakukan di Laboratorium Hama Penyakit Tanaman Fakultas Pertanian Universitas Brawijaya dan Laboratorium Metria Medica Batu Malang pada 22 Oktober 2018. Penelitian ini menggunakan metode eksperimen dengan desain Rancangan Acak Lengkap (RAL) terdiri atas 4 perlakuan dan 6 ulangan. Perlakuan P0 (Isolat bakteri + Aquades 30 %), P1 (Isolat bakteri + Larutan konsentrasi tepung daun kenikir 30%), P2 (Isolat bakteri + Larutan konsentarsi tepung batang kenikir 30%), P3 (Isolat bakteri + Larutan konsentrasi tepung daun dan batang kenikir 30%). Parameter yang diamati adalah daya hambat tepung bagian-bagian tanaman kenikir terhadap bakteri Salmonella sp, Escherichia coli dan evaluasi senyawa aktif flavonoid, polifenol dan saponin dari tepung tanaman kenikir. Hasil penelitian menunjukan bahwa pengaruh perbedaan tepung bagian tanaman kenikir terhadap daya hambat bakteri, sangat berpengaruh nyata (P<0,01) terhadap bakteri Salmonella sp dan Escherichia coli.
Aplikasi FMA (Fungi Mikoriza Arbuskula) dan Pupuk Kompos Dengan Level Berbeda pada Pertumbuhan dan Produksi Biomasa Rumput Setaria Sphacelata
Authors: Nahak Oktovianus R. , Ulu Beatrix R. , Neonbeni Eduardus Y.
Published: May 2023

Percobaan telah dilakukan dengan memanfaatkan FMA dan pupuk kompos, untuk meningkatkan pertumbuhan dan hasil tanaman rumput setaria sphacelata. Penelitian bertujuan untuk mengetahui interaksi antara kombinasi pemberian FMA (Fungi Mikoriza Arbuskula) dan pupuk kompos pada pertumbuhan dan produksi biomasa rumput Setaria Sphacelata. Penelitian telah dilaksanakan di kebun percobaan Fakultas Pertanian, Universitas Timor, Kelurahan Sasi, Kecamatan Kota Kefamenanu, Kabupaten Timor Tengah Utara. Penelitian berlangsung selama 3 bulan dimana pengambilan data dilakukan pada 2 masa produksi yaitu : produksi I : 45 hari setelah tanam dan produksi ke II 90 hari setelah tanam. Penelitian dimulai dari awal Juni sampai akhir Agustus 2019, menggunakan Rancangan Acak Kelompok (RAK). Faktor pertama adalah level Fungi Micoriza Arbuscula (FMA) (F) yaitu: Tanpa Fungi Micoriza Arbuscula (kontrol) (F0) dan Fungi Micoriza Arbuscula 50 g/lubang tanam (F1). Faktor kedua adalah level pupuk kompos (P) yaitu:Tanpa pupuk kompos (kontrol) (P0), Pupuk kompos 500 g/lubang tanam (P1) dan Pupuk kompos 750 g/lubang tanam (P2). Hasil sidik ragam (Anova) menunjukan bahwa level FMA dan level pupuk kompos pada umumnya tidak berinteraksi secara positif (P>0.05), dalam mempengaruhi semua variabel yang diamati. Hasil penelitian menunjukan bahwa pemberian level FMA 50 g/lubang tanam dan level pupuk kompos 500 g/lubang tanam menunjukan hasil yang terbaik yang dapat diekspresikan dalam bentuk jumlah anakan pada produksi I dan II terbanyak dan berat segar dan kering tajuk produksi I dan II terberat. Simpulan dari hasil peneltian ini adalah pada jumlah anakan produksi I= 8,48 dan produksi II= 15,36, berat segar tajuk produksi I= 40,97 dan produksi II = 76,77, berat kering tajuk produksi I= 9,50 dan produksi II= 14,32. Terjadi beda nyata antar perlakuan dengan level FMA dan Level kompos yang berbeda pada semua parameter yang diamati.
Analisis Faktor-Faktor Yang Mempengaruhi Tingkat Pengangguran Terbuka Di Kabupaten Pelalawan
Authors: Fahanisa Alya
Published: May 2023

The problem of unemployment is a condition where the fulfillment of the rights to welfare and work has not been fulfilled. Unemployment has always been a problem that needs to be addressed in the economy. In addition, economic conditions that are not always in a normal stable condition are in line with the policies implemented to achieve a better economy. This study aims to see the effect of the Labor Force Participation Rate (X1), Human Development Index (X2), GRDP (X3) and Minimum Wage (X4) on the Open Unemployment Rate (Y) in Pelalawan Regency. This type of research is descriptive research. The data processed is data published by the Central Statistics Agency in the form of Labor Force Participation Rate, Human Development Index, GRDP, and Minimum Wage for 2012-2021. The technique used in this research is multiple linear regression. While the hypothesis test uses the t test to test the variables partially, and the f test to test the variables simultaneously with a significance level below 0.05. From the test results in this study, it is known that partially with the t test that the Labor Force Participation Rate has a negative and insignificant effect, the Human Development Index has a positive and significant effect, GRDP has a positive and insignificant effect. And the Minimum Wage has a positive and significant effect.
Strategi Pengembangan Objek Wisata Pantai Faularan Desa Tuamese Kecamatan Biboki Anleu, Kabupaten Timor Tengah Utara
Authors: Afenpah Oliva , Nalle Frederich Winston , Andari Ismi
Published: May 2023

Masalah utama dalam penelitian ini adalah kualitas infrastruktur jalan yang belum memadai, kurangnya fasilitas penunjang objek wisata seperti lopo, tempat sampah, kamar mandi/Wc serta tempat duduk disekitaran pantai, minimya promosi objek wisata dan tidak adanya tindak lanjut dari pemerintah daerah maupun pemerintah desa untuk mengembangkan objek wisata. Rumusan masalah dalam penelitian ini adalah bagaimana strategi pengembangan objek wisata  Pantai Faularan, Desa Tuamese, Kecamatan Biboki Anleu, Kabupaten TTU. Penelitian ini bertujuan untuk mengetahui strategi pengembangan objek wisata Pantai Faularan, Desa Tuamese, Kecamatan Biboki Anleu, Kabupaten TTU. Penelitian ini di lakukan pada Pantai Faularan, Desa Tuamese, Kecamatan Biboki Anleu, Kabupaten TTU. Data yang digunakan dalam penelitian ini adalah data primer yang diambil menggunakan kuisioner yang telah disesuaikan dengan  indikator setiap variabel yakni variabel kekuatan, kelemahan, peluang dan ancaman. Sampel dalam penelitian ini berjumlah 90 responden. Alat analisis yang digunakan dalam penelitian ini adalah analisis SWOT. Hasil penelitian menunjukan bahwa objek wisata pantai Faularan Tuamese memiliki nilai faktor internal ( IFAS) sebesar 3,862 yang terdiri dari kekuatan sebesar 1,712 dan kelemahan sebesar 2,150. Kemudian faktor eksternal (EFAS) sebesar 4,00 yang terdiri dari peluang sebesar 2,056 dan ancaman sebesar 1,944. Hasil analisis SWOT menggunakan diagram cartesius menunjukkan bahwa objek wisata pantai Faulran Tuamese berada pada Kuadran III (Negatif-Positif) dengan faktor internal (kekuatan – kelemahan) sebesar -0,438 dan faktor eksternal (peluang – ancaman) sebesar 0,112, di mana posisi ini menandakan objek wisata pantai Faularan Tuamese yang lemah namun sangat berpeluang. Rekomendasi strategi yang diberikan adalah ubah strategi, artinya instansi terkait dalam pengembangan objek wisata pantai Faularan disarankan untuk mengubah strategi sebelumnya. Sebab, strategi yang lama dikhawatirkan sulit untuk dapat menangkap peluang yang ada sekaligus memperbaiki kinerja organisasi.
Determinan Penyerapan Tenaga Kerja Industri Manufaktur Besar dan Sedang Jawa Timur
Authors: Widodo Putri Eka Nugrahani , Woyanti Nenik
Published: May 2023

Sektor industri di Jawa Timur memiliki kontribusi tertinggi terhadap struktur PDRB yang diharapkan meningkatkan penyerapan tenaga kerja. Penelitian ini bertujuan untuk menganalisis: 1) Pengaruh PDRB, unit usaha, dan UMK terhadap penyerapan tenaga kerja industri manufaktur besar dan sedang di Provinsi Jawa Timur tahun 2015-2019 2) Faktor yang paling dominan pengaruhnya terhadap penyerapan tenaga kerja industri manufaktur di Provinsi Jawa Timur tahun 2015 – 2019. Variabel yang digunakan adalah PDRB, unit usaha, dan UMK di Jawa Timur menggunakan data sekunder dari tahun 2015 hingga 2019. Metode analisis yaitu regresi data panel dan Fixed Effect Model. Hasil regresi menunjukkan bahwa unit usaha berpengaruh positif dan signifikan, PDRB berpengaruh positif dan tidak signifikan dan UMK berpengaruh negatif dan tidak signifikan terhadap penyerapan tenga kerja industri manufaktur besar dan sedang di Jawa Timur tahun 2015 - 2019. Variabel yang paling dominan adalah unit usaha.
Modifikasi Algoritma Controlling Expansion Dalam Meningkatan Kapasitas Penyisipan Data Hiding
Authors: Fallo Kristoforus
Published: May 2023

Stegonography is the art of hiding messages in other media. Stegonography is widely used to send secret messages without being known by other people by using digital media in the form of image files so that besides the sender and recipient no one knows or is aware that there is a secret message in it. Several researchers have developed these methods such as Difference Expansion, Reduced Difference Expansion, Quad Difference Expansion and Controlling Expansion. These methods have been able to recover and improve data embedding but during the running process there are several problems that often occur, namely overflow and underflow of pixel values. To overcome the above problems, we modify the Controlling Expansion algorithm by minimizing the condition of the pixel difference value and reducing the final pixel difference value after inserting the data bit and using the Location Map on the new pixel value and during secret data extraction. The experimental results show that the proposed method can increase the data storage capacity and the PSNR of stego images is higher than the previous method.
Resolving large-scale genome evolution in the high-throughput sequencing era: structural variants, genome rearrangement, and karyotype dynamics in animals
Authors: Diblasi Célian , Barson Nicola , Saitou Marie
Published: May 2023

Genomic structural variation, genomic rearrangements and karyotype variants are important components on which evolution acts in addition to single nucleotide variants, which are the most common type of variant being studied since the rise of next generation sequencing. These variants have unique mutational mechanisms and evolutionary consequences compared to single nucleotide variants. Here we review the history and methods used to study genomic structural variants in animals, including technical challenges of current methods and promising new approaches. We then review case studies to illustrate how large genomic variants can drive interesting evolutionary phenomena. Meanwhile, most studies are limited to specific taxa and there remain many unanswered questions. We conclude that the time is ripe to expand study on genomic structural variants to various non-model species and across taxa by utilizing cutting edge technologies to open a new door in evolutionary genomics.
Individualisation and Individualised Science: Integrating Disciplinary Perspectives
Authors: Kaiser Marie , Killin Anton , Malsch Annette , Abendroth Anja-Kristin , Back Mitja , Baune Bernhard , Bilstein Nicola , Breitmoser Yves , Caspers Barbara , Gadau Jürgen , Gossmann Toni , Kaiser Sylvia , Krüger Oliver , Kurtz Joachim , Lengersdorf Diana , Müller Caroline , Rauthmann John , Reinhold Klaus , Richter S. Helene , Stummer Christian , Trappes Rose , Voelcker-Rehage Claudia , Wittmann Meike
Published: May 2023

Recent trends in a range of scientific fields have seen a shift towards research and methods concerning individual differences and individualisation. This article brings together various scientific disciplines—ecology, evolution, and animal behaviour; medicine and psychiatry; public health and sport/exercise science; sociology; psychology; economics and management—and conceptually integrates their research on individualisation. We clarify the concept of individualisation by distinguishing three kinds of individualisation studied in these disciplines: IndividualisationONE as creating/changing individual differences, IndividualisationTWO as individualising applications, and IndividualisationTHREE as social changes influencing autonomy, risk, and responsibilities. This also elucidates how individualisation is related to individual differences. Drawing on recent work in philosophy of biology, we analyse conceptual links between individualisation and individuality and clarify the different sorts of individuality that the disciplines study. This paper promotes interdisciplinary research concerning individualisation by establishing a common conceptual theoretical basis, while leaving room for disciplinary differences.
Когнітивно-поведінкова терапія низької інтенсивності соціального тривожного розладу осіб у період горювання
Authors: Аврамчук Олександр Сергійович , Ніздрань Олександра Андріївна , Блозва Павло Ігорович
Published: May 2023

Метою дослідження є отримання підтверджуючихданих зниження тяжкості симптомів та рівня психо-соціального дисфункціонування під впливом техніккогнітивно-поведінкової терапії (далі КПТ) низькоїінтенсивності серед осіб зі соціальним тривожним розладом у період горювання. Методи: з метоюоцінки проблем психічного здоров’я під час первинного діагностичного інтерв’ювання використаноМіжнародне нейропсихіатричне інтерв’ю (MINI).Вимірювання основних показників здійснювалосяза допомогою методик: рівень тяжкості симптомів соціального тривожного розладу (SPIN), рівеньпсихосоціального дистресу, внаслідок пережиттявтрати та ризик ускладненого горювання, коморбідні стани як рівень генералізованої тривожності (GAD-7), вираженість емоційного уникнення(AAQ-II), загальний рівень дистресу у повсякденній та робочій активності вимірювався за шкалоюW&SAS. Результати. Результати змін психічногостану до і після проходження програми засвідчилизначущі покращення для показників генералізованої тривожності, тяжкості коморбідних депресивних симптомів, впливу травматичного досвіду,зниження емоційного уникнення та супутніх психо-соціальних порушень. Поруч із цим, зниження тяжкості симптомів соціальної фобії та дистресу, що асоціюються з досвідом втрати, не продемонструвалистатистично значущої відмінності. Через 1 місяцьпісля завершення програми для опанування дистресу учасниками частіше використовувалисястратегії, які стосувалися контролю дихання (включаючи практики майндфулнесу) та опрацюваннядумок у ситуаціях уникнення соціальних стосунківчи спільної діяльності. Через 6 місяців після завершення програми найчастіше у відгуках учасниківзгадуються протистояння та робота з дисфункційними переконаннями щодо наслідків подій і соціальних ситуацій, що сприяли запобіганню актуалізації захисної поведінки через уникнення. Висновки.Індивідуальна онлайн-програма психосоціальноїдопомоги низької інтенсивності на основі КПТ дляосіб, які страждають від соціального тривожногорозладу й опинились у складних життєвих обставинах (як втрата близької людини), продемонструвалазменшення психосоціального дистресу та тяжкостіпсихічних симптомів. З’ясовано, що задоволеннясоціальних потреб і коригуючий досвід безпечногосоціального простору для горювання сприятимутьпсихологічному благополуччю та виступатимуть якпротективні чинники до загострень проблем психічного здоров’я.
Self-Assembling Nanodiscs Technology Exploration with Single-Molecule Biophysics Experimentation using Site-Specific Attachment Atomic Force Microscopy
Authors: Talder Stephanie Elizabeth
Published: May 2023

The relationship between membrane proteins and functional cells is not yet fully understood, in large part due to the lack of knowledge about the structure and dynamics of membrane proteins. Because of the recent advancement of biotechnology, the visualization of membrane protein dynamics and energetics has progressed significantly, in large part due to nanodisc technology. Nanodiscs allow for the formation of a native environment for membrane proteins, which is essential to learning more about their structure. Atomic force microscopy (AFM) allows for the precise imaging of membrane proteins as well as the utilization of single-molecule force spectroscopy (SMFS). When completing single-molecule experimentation, it is crucial that the covalent attachment of the probe is completed, because it allows for hundreds of force-extension traces from a single molecule to be completed. Another essential aspect of site-specific attachment is passivation is necessary for unwanted interactions between the AFM cantilever tip and a single probe molecule. The focus of my senior thesis is to work with the optimization of nanodisc technology formation embedded with the membrane protein bacteriorhodopsin (bR). The bR was inserted into nanodiscs in both wild-type and c-terminal cysteine transformed to allow for site-specific labeling. The formation of nanodiscs with c-terminal cysteine bR was then labeled with DBCO-Maleimide tagging to allow for covalent connections when utilizing AFM SMFS. Altogether, this work shows a methodology for the optimization of nanodisc formation containing c-terminal cysteine bR membrane protein and warrants further investigation utilizing AFM imaging and SMFS with varying conditions of site-specific spectroscopy to target the development of protein-membrane dynamics.
To see the complete thesis, please visit https://scholar.colorado.edu/concern/undergraduate_honors_theses/xg94hq786.
Violets
Authors: Roberts Max
Published: May 2023

Acrylic Painting on Canvas
Dimensions: 18" x 24"
Honoring and remembering the black lesbians who fought for all LGBTQ+ rights. Yellow and violets represent symbols of the lesbian identity, and the figure is confidently gazing at the viewer. Many of these women were forgotten in our modern narrative, this piece is giving them their rightful place in LGBTQ+ history.
Discovering the Best Method of Judicial Selection
Authors: Gafari Aaron Shaw
Published: May 2023

As the American Judiciary becomes a more active vehicle for progressing policy and partisanship, this paper examines what method of judicial selection we ought to prefer. That is, how we should prefer that state supreme court justices get to the bench. To answer this question, I first analyze the empirical data surrounding each of the four main and general selection methods used across states today (partisan elections, nonpartisan elections, merit selection, and appointment) and identify what general trends exist. Once these trends have been established, I then move into a philosophical discussion that asks what trends we ought to prefer in a given selection method, and what traits we ought to avoid. The question ends up being one of whether we should advocate for an independent judiciary, or one accountable to public opinion. I advocate for the former and the most independent selection method: merit selection.
To see the complete thesis, please visit https://scholar.colorado.edu/concern/undergraduate_honors_theses/ng451j91n.
Phosphate Ester Bond Chemistry with Zirconium (IV) Catalysts
Authors: Nathaniel Bunnell  , Robert Kuchta
Published: May 2023

Earth’s infancy was a time of immense chemical complexity. Over many millions of years, steady chemical cycles were formed and driven by thermodynamics and organic precursors left over from the planet’s formation. In aqueous environments, this chemistry may have led to the formation of catalytic RNA species capable of information storage and replication. Presumably, the formation of these oligonucleotides was catalyzed by primordial Earth’s abundant mineral content. However, the species that accelerated these types of transformations are unknown. In this study, the role of Zr+4 in the catalytic formation of phosphate ester bonds was explored. Through TLC screening, it was found that most of the test conditions produced no observable phosphorylated products. In the final samples, there were highly polar spots which may have contained phosphate-bearing compounds. These findings provide mixed certainty about zirconium’s catalytic capacity for ester formation but suggest that zirconium metal organic frameworks (MOFs) and alternative metal ions may be viable routes for future investigation.
Lay Summary
Earth began as a planet of rock and magma, hardly recognizable without the biological adornments that characterize it today. For nearly a billion years, consistent comet and asteroid impacts heated the planet and vaporized any reservoirs of water or organic matter that covered the surface. As this bombardment subsided, life came to fruition in half the time that the mineral rain had lasted. The question of how this transition occurred is one of the most elusive in the biochemical field. In particular, it is still unknown how all life, whether primordial or modern, came to share polynucleotides as an essential coding system for all their requisite biological functions.
This study explored the role of Zr+4, an abundant mineral on early Earth, in the catalytic formation of phosphate ester bonds, the core linkages in DNA and RNA. Through TLC screening, it was found that most of the test conditions produced no observable phosphorylated products. In the final samples, highly polar spots may have contained phosphate-bearing compounds. These findings provide mixed certainty about zirconium’s capacity for ester formation but suggest that zirconium metal-organic frameworks (MOFs) and alternative metal ions that reflect early Earth’s composition may be viable routes for future investigation into this grand mystery.
To see the complete thesis, please visit https://scholar.colorado.edu/concern/undergraduate_honors_theses/cf95jc857.
PELATIHAN SOFTWARE R UNTUK ANALISIS DESKRIPTIF SEBAGAI UPAYA PENINGKATAN KEMAMPUAN GURU DALAM OLAH DATA
Authors: Juliza Melda , Angreni Puce
Published: May 2023

Kegiatan pengabdian masyarakat ini dilakukan dengan upaya untuk memperbaharui pengetahuan dan wawasan para guru dalam meningkatkan kemampuan teknologi dimasa sekarang. Terutama dalam hal aplikasi selain Microsoft Office Excel pendukung pembelajaran dan tugas guru, khususnya dalam penyajian data. Oleh karena itu, kegiatan pelatihan pengabdian masyarakat ini difokuskan untuk meningkatkan kemampuan guru memahami konsep statistika deskriptif secara tepat, khususnya dalam penyajian data menggunakan software R. Tujuan diadakan pelatihan ini supaya dewan guru SMK 5 Kaur memiliki kemampuan dalam mengoperasikan aplikasi R dalam analisis deskriptif. Adapun manfaat pelatihan analisis data statistika menggunakan aplikasi R bagi dewan guru diantaranya adalah mengetahui cara menjalankan aplikasi R, memanggil data dari excel pada aplikasi R, dan melakukan analisis deskriptif  menggunakan aplikasi R. Metode pelaksanaan kegiatan pengabdian dengan ceramah dan praktek. Kegiatan pelatihan meliputi pemaparan materi dilanjutkan dengan praktek. Harapannya, Hasil kegiatan ini diharapkan bermanfaat bagi dewan guru SMK 5 Kaur, sehingga lebih aktif dan produktif dalam menunjang tugas pokok dan fungsinya.
PENDAMPINGAN GURU RAUDHATUL ATHFAL DALAM PENINGKATAN KOMPETENSI PEMBELAJARAN ANAK USIA DINI DI IGRA KAB. REJANG LEBONG
Authors: H.M.Taufik Amrillah,  , Muksal Mina Putra  , Amanah Rahma Ningtyas  , Meri Hartati  , Rizki Yunita Putri1
Published: May 2023

Tujuan kegiatan pengabdian masyarakat ini untuk memberikan pendampingan pada Guru Raudhatul athfal (RA) dalam hal peningkatan kompetensi guru Raudhatul Athfal. Untuk mencapai hal tersebut dilakukan kegiatan pelatihan penyusunan perangkat perencanaan pembelajaran. Kegiatan Pengabdian Masyarakat ini dilaksanakan di RA Tunas Literasi Qur’ an di desa Tasik Dusun Curup. Hasil dari kegiatan ini adalah terciptanya kegiatan pembelajaran yang sesuai dengan perangkat perencanaan pembelajaran yang terdiri dari, prigram tahunan, program semester, rencana perencanaan pembelajaran mingguan, rencana perencanaan pembelajaran harian dan evaluasi pembelajaran.
ANALISIS KUALITAS DAN KUANTITAS UDARA PADA SISTEM VENTILASI TAMBANG BAWAH TANAH KENCANA DI PT. NUSA HALMAHERA MINERALS
Authors: Adam Iksan Muksin , Nurany Nurany , Latif Anas Abdul , Sahetapy George Belly
Published: May 2023

Dalam metode tambang bawah tanah penting adanya sistem ventilasi yang baik, ventilasi merupakan upaya pengontrolan terhadap kualitas dan kuantitas udara pada aliran udara di penambangan bawah tanah. Pengukuran dilakukan secara kuantitatif di lapangan berupa data Psikometri, luas lubang bukaan, velocity, dan Pressure Vent duct. Kualitas dan kuantitas udara di tambang bawah tanah kencana dikaji dengan memperhitungkan nilai Thermal Work Limit, debit udara yang masuk dan keluar serta kehilangan energi (head loss) pada secondary fan. Berdasarkan hasil pengolahan data diperoleh, ada 7 front yang berada pada zona aklimatisasi yang berada pada rentang nilai 140 â€“ 219 dan 2 front yang berada pada zona buffer yang berada pada rentang nilai 116 â€“ 139, 2 front berada pada zona buffer dikarenakan win speed yang sampai ke face rendah. Hasil pengolahan data debit udara secara kondisi aktual dan simulasi diperoleh udara di jalur exhaust lebih besar dibandingkan dengan udara di jalur fresh air, hal ini dikarenakan adanya kebocoran pada vent door yang membatasi antara jalur fresh air dan exhaust. Hasil pengolahan data pressure Vent duct pada 4 front diperoleh adanya banyak perubahan lintasan dan kebocoran serta jarak motor fan ke face yang jauh secara aktual hal ini menyebabkan udara yang sampai di face juga berkurang, hasil secara aktual dan teori jika dikomparasikan akan mengalami perbedaan karena secara teori jalur Vent duct lurus hasilnya yaitu pada teori di front KNF SB14B SILL dengan jarak 400 m dan pada kondisi aktual adalah 309 m, udara yang seharusnya sampai di face secara teori adalah 35.21 m3/s namun pada kondisi aktual adalah 15.05 m3/s. pada front K1 SB07B UC01 Teori 400 m dan 35.21 m3/s, aktual 320 m dan 13.66 m3/s, front KL SB10A UC03 Teori 400 m dan 26.72 m3/s, aktual 382 m dan 13.66 m3/sÂ  dan front K2 SB09H UC01 Teori 350 m dan 28.62 m3/s, aktual 331 m dan 12.16 m3/s.Kata kunci: Ventilasi, Psikometri, Debit Udara, Vent duct, Head Loss Â Â
BERTOLT BRECHT'S DEUTSCHLAND POEM WHICH DESCRIBES THE INHUMANITIES OF THE HITTLER ERA'S LEADERSHIP
Authors: Girsang Martina , Damanik Andrini Aurellia Anggi , Tambunan Putri Yustika , Silitonga Ruth Friska , Tamba Septriyuni Rumondang
Published: May 2023

Poetry (Gedich) is a literary work that belongs to the category of lyrics. Compared to other types of literary works such as epics and dramas, poetry has a more dense and beautiful language and the meaning in poetry is multi-interpreted. Each individual can have their own interpretation. The language used in poetry is also not everyday language. Tells about the struggle of the German people during the Nazi occupation, and the sadness of the German people who live with great difficulties. So this poem explains the condition of Hitler’s leadership which did not put humanity first, so that many died in the end and it was the nation’s best sons who were sacrificed for war with the condition that all access was limited. The creation of meaning in Deutschland poetry is caused by rhyme and enjambement. The rhyme in the poem is irregular, this illustrates that what is characteristic of beauty is not prioritized, but emphasizes the integrity of meaning. Apart from rhyme, Enjambement is also found in poetry.Germany is also hated by other countries due to Hitler’s actions. Initially Hitler’s decision to annex Austria (15 March 1938) and Czechoslovakia was still tolerated by other nations, but then the dispossession of Poland had precipitated the outbreak of World War II.
Oncogenic roles and related mechanisms of the long non-coding RNA MINCR in human cancers
Authors: Chao Ce , Tang Renzhe , Zhao Jiamin , Di Dongmei , Qian Yongxiang , Wang Bin
Published: May 2023

Long non-coding RNAs (lncRNAs) play vital roles in regulating epigenetic mechanisms and gene expression levels, and their dysregulation is closely associated with a variety of diseases such as cancer. Several studies have demonstrated that lncRNAs are dysregulated during tumor progression. Recently, the MYC-induced long non-coding RNA MINCR, a newly identified lncRNA, has been demonstrated to act as an oncogene in different cancers, including gallbladder cancer, hepatocellular cancer, colorectal cancer, non-small cell lung cancer, oral squamous cell carcinoma, nasopharyngeal cancer, and glioma. Moreover, MINCR has been reported to act as a biomarker in the prognosis of patients with different cancers. In this review, we summarize and analyze the oncogenic roles of MINCR in a variety of human cancers in terms of its clinical significance, biological functions, cellular activities, and regulatory mechanism. Our analysis of the literature suggests that MINCR has potential as a novel biomarker and therapeutic target in human cancers.
The versatile defender: exploring the multifaceted role of p62 in intracellular bacterial infection
Authors: Zhou Yuhao , Hua Shucheng , Song Lei
Published: May 2023

As a highly conserved, multifunctional protein with multiple domains, p62/SQSTM1 plays a crucial role in several essential cellular activities, particularly selective autophagy. Recent research has shown that p62 is crucial in eradicating intracellular bacteria by xenophagy, a selective autophagic process that identifies and eliminates such microorganisms. This review highlights the various roles of p62 in intracellular bacterial infections, including both direct and indirect, antibacterial and infection-promoting aspects, and xenophagy-dependent and independent functions, as documented in published literature. Additionally, the potential applications of synthetic drugs targeting the p62-mediated xenophagy mechanism and unresolved questions about p62’s roles in bacterial infections are also discussed.
Application of a bivariate bias-correction approach to yield long-term attributes of Indian precipitation and temperature
Authors: Gupta Chanchal , Bhowmik Rajarshi Das
Published: May 2023

The General Circulation Model (GCM) simulation had shown potential in yielding long-term statistical attributes of Indian precipitation and temperature which exhibit substantial inter-seasonal variation. However, GCM outputs experience substantial model structural bias that needs to be reduced prior to forcing them into hydrological models and using them in deriving insights on the impact of climate change. Traditionally, univariate bias correction approaches that can successfully yield the mean and the standard deviation of the observed variable, while ignoring the interdependence between multiple variables, are considered. Limited efforts have been made to develop bivariate bias-correction over a large region with an additional focus on the cross-correlation between two variables. Considering these, the current study suggests two objectives: (i) To apply a bivariate bias correction approach based on bivariate ranking to reduce bias in GCM historical simulation over India, (ii) To explore the potential of the proposed approach in yielding inter-seasonal variations in precipitation and temperature while also yielding the cross-correlation. This study considers three GCMs with fourteen ensemble members from the Coupled Model Intercomparison project Assessment Report-5 (CMIP5). The bivariate ranks of meteorological pairs are applied on marginal ranks till a stationary position is achieved. Results show that the bivariate approach substantially reduces bias in the mean and the standard deviation. Further, the bivariate approach performs better during non-monsoon months as compared to monsoon months in reducing the bias in the cross-correlation between precipitation and temperature as the typical negative cross-correlation structure is common during non-monsoon months. The study finds that the proposed approach successfully reproduces inter-seasonal variation in metrological variables across India.
The appeal to emotions in the discourse of populist political actors from Spain, Italy, France and the United Kingdom on Twitter
Authors: Alonso-Muñoz Laura , Casero-Ripollés Andreu
Published: May 2023

Western democracies live a populist impulse. In this context, the consolidation of digital technologies plays a key role due to their possibilities of efficiently spreading messages. This research examines the role that emotions play in the communication strategy on Twitter of populist actors from four European countries: Spain, Italy, France and the United Kingdom. The sample comprises the messages shared by four European political parties: Podemos, 5 Star Movement, National Front and UKIP and their respective leaders during the analysis period. In total, 9,128 messages are analyzed. The main findings show that fear, uncertainty or resentment are the emotions most frequently used by populist parties and leaders. Likewise, negative emotions have been observed in those messages whose primary actor is the political, economic and media classes, the European Union or immigration, while positive emotions, such as joy or pride, are associated with the figure of the leader and the party.
Effects of E-health-based interventions on glycemic control for patients with type 2 diabetes: a Bayesian network meta-analysis
Authors: Zhang Xiaoyue , Zhang Lanchao , Lin Yuxin , Liu Yihua , Yang Xiaochen , Cao Wangnan , Ji Ying , Chang Chun
Published: May 2023

The high disease burden of type 2 diabetes seriously affects the quality of life of patients, and with the deep integration of the Internet and healthcare, the application of electronic tools and information technology to has become a trend for disease management. The aim of this study was to evaluate the effectiveness of different forms and durations of E-health interventions in achieving glycemic control in type 2 diabetes patients. PubMed, Embase, Cochrane, and Clinical Trials.gov were searched for randomized controlled trials reporting different forms of E-health intervention for glycemic control in type 2 diabetes patients, including comprehensive measures (CM), smartphone applications (SA), phone calls (PC), short message service (SMS), websites (W), wearable devices (WD), and usual care. The inclusion criteria were as follows: (1) adults (age≥18) with type 2 diabetes mellitus; (2) intervention period ≥1 month; (3) outcome HbA1c (%); and (4) randomized control of E-health based approaches. Cochrane tools were used to assess the risk of bias. R 4.1.2 was used to conduct the Bayesian network meta-analysis. A total of 88 studies with 13,972 type 2 diabetes patients were included. Compared to the usual care group, the SMS-based intervention was superior in reducing HbA1c levels (mean difference (MD)-0.56, 95% confidence interval (CI): -0.82 to -0.31), followed by SA (MD-0.45, 95% CI: -0.61 to -0.30), CM (MD-0.41, 95% CI: -0.57 to -0.25), W (MD-0.39, 95% CI: -0.60 to -0.18) and PC (MD-0.32, 95% CI: -0.50 to -0.14) (p < 0.05). Subgroup analysis revealed that intervention durations of ≤6 months were most effective. All type of E-health based approaches can improve glycemic control in patients with type 2 diabetes. SMS is a high-frequency, low-barrier technology that achieves the best effect in lowering HbA1c, with ≤6 months being the optimal intervention duration.

Systematic review registration

https://www.crd.york.ac.uk/prospero, identifier CRD42022299896.
Maternal elevated inflammation impairs placental fatty acids β-oxidation in women with gestational diabetes mellitus
Authors: Visiedo Francisco , Vázquez-Fonseca Luis , Ábalos-Martínez Jessica , Broullón-Molanes J. Román , Quintero-Prado Rocío , Mateos Rosa María , Bugatto Fernando
Published: May 2023

Introduction

An adverse proinflammatory milieu contributes to abnormal cellular energy metabolism response. Gestational diabetes mellitus (GDM) is closely related to an altered maternal inflammatory status. However, its role on lipid metabolism regulation in human placenta has not yet been assessed. The aim of this study was to examine the impact of maternal circulating inflammatory mediators ([TNF]-α, [IL]-6, and Leptin) on placental fatty acid metabolism in GDM pregnancies.

Methods

Fasting maternal blood and placental tissues were collected at term deliveries from 37 pregnant women (17 control and 20 GDM). Molecular approach techniques as radiolabeled lipid tracers, ELISAs, immunohistochemistry and multianalyte immunoassay quantitative analysis, were used to quantify serum inflammatory factors’ levels, to measure lipid metabolic parameters in placental villous samples (mitochondrial fatty acid oxidation [FAO] rate and lipid content [Triglycerides]), and to analyze their possible relationships. The effect of potential candidate cytokines on fatty acid metabolism in ex vivo placental explants culture following C-section a term was also examined.

Results

Maternal serum IL-6, TNF-α and leptin levels were significantly increased in GDM patients compared with control pregnant women (9,9±4,5 vs. 3,00±1,7; 4,5±2,8 vs. 2,1±1,3; and 10026,7±5628,8 vs. 5360,2±2499,9 pg/ml, respectively). Placental FAO capacity was significantly diminished (~30%; p<0.01), whereas triglyceride levels were three-fold higher (p<0.01) in full-term GDM placentas. Uniquely the maternal IL-6 levels showed an inverse and positive correlation with the ability to oxidize fatty acids and triglyceride amount in placenta, respectively (r= -0,602, p=0.005; r= 0,707, p=0.001). Additionally, an inverse correlation between placental FAO and triglycerides was also found (r=-0.683; p=0.001). Interestingly, we ex vivo demonstrated by using placental explant cultures that a prolonged exposure with IL-6 (10 ng/mL) resulted in a decline in the fatty acid oxidation rate (~25%; p=0.001), along to acute increase (2-fold times) in triglycerides accumulation (p=0.001), and in lipid neutral and lipid droplets deposits.

Conclusions

Enhanced maternal proinflammatory cytokines levels (essentially IL-6) is closely associated with an altered placental fatty acid metabolism in pregnancies with GDM, which may interfere with adequate delivery of maternal fat across the placenta to the fetus.
Quantity and spatial imbalance of supply and demand for water yield services in terrestrial ecosystems under different future land use scenarios in Xinjiang, China
Authors: Liu Zhuo , Shi Mingjie , Wu Hongqi , Jiang Pingan , Zhang Haoyu , He Panxing , Zheng Kai , Dong Tong , Zhang Yue
Published: May 2023

Drylands in northwest China have limited water resources, which negatively impacts economic development, ecological security, and the United Nations Sustainable Development Goals. However, few studies have examined water supply and demand under multiple future spatial patterns of land use, particularly under sustainable development scenarios. Further research is therefore needed to determine how affect water output services under various land use patterns. We used the GMOP-PLUS (Gray Multi-objective Optimization-Patch-generating Land Use Simulation) and the InVEST (Integrated Valuation of Ecosystem Services and Tradeoffs) models to investigate future land use programs and the current and future trends in water yield services supply and demand in the typical dryland region of Xinjiang, China. The GMOP-PLUS model was used to project the spatial patterns of land use/land cover (LULC) change in Xinjiang in 2025 and 2030 under programs of business-as-usual, rapid economic development, ecological land protection and sustainable development. We then used the InVEST model to project the spatiotemporal evolution of water yield services supply and demand under the four different scenarios. Our results show that Our results show that water production in Xinjiang decreases to 911.30 × 108 m3 in 2020–2030 under the business-as-usual scenario, with an expansion in arable land and a reduction in forested land being the main causes of this decrease. The decline in water production under the ecological land protection scenario is 913.88 × 108 m3. The retention effect of vegetation slows the decline in water production, but the ecological land protection scenario is not effective in controlling the reduction in arable land. The rapid economic development scenario produces a significant increase in water yield of 915.09 × 108 m3, mainly due to an increase in the area of impervious surfaces caused by the expansion of built-up land; however, the rapid economic development scenario leads to a decreasing trend in ecological land. The sustainable development scenario produces 914.15 × 108 m3 of water. The sustainable development scenario increases water production while balancing the development of Constructed and the protection of ecological land, and the arable land also shows a slow growth trend. Between 2025 and 2030, the water security index fluctuates between –0.0225 and –0.0400, with a continued future deficit in water supply and demand in Xinjiang and a high degree of spatial heterogeneity. Programs for advancing sustainable development narrow the supply–demand gap for services that produce water.