bluuebunny/crossref_metadata_2025 huggingface dataset:
Neuroprotective Properties of Eudesmin on a Cellular Model of Amyloid-β Peptide Toxicity
Authors: Castillo Carolina , Bravo-Arrepol Gastón , Wendt Aline , Saez-Orellana Francisco , Millar Camila , Burgos Carlos F. , Gavilán Javiera , Pacheco Carla , Ahumada-Rudolph Ramón , Napiórkowska Mariola , Pérez Claudia , Becerra José , Fuentealba Jorge , Cabrera-Pardo Jaime R.
Published: November 2022

Background:

Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by progressive cognitive impairment and memory loss. One of the hallmarks in AD is amyloid-β peptide (Aβ) accumulation, where the soluble oligomers of Aβ (AβOs) are the most toxic species, deteriorating the synaptic function, membrane integrity, and neuronal structures, which ultimately lead to apoptosis. Currently, there are no drugs to arrest AD progression, and current scientific efforts are focused on searching for novel leads to control this disease. Lignans are compounds extracted from conifers and have several medicinal properties. Eudesmin (Eu) is an extractable lignan from the wood of Araucaria araucana, a native tree from Chile. This metabolite has shown a range of biological properties, including the ability to control inflammation and antibacterial effects.

Objective:

In this study, the neuroprotective abilities of Eu on synaptic failure induced by AβOs were analyzed.

Methods:

Using neuronal models, PC12 cells, and in silico simulations we evaluated the neuroprotective effect of Eu (30 nM) against the toxicity induced by AβOs.

Results:

In primary cultures from mouse hippocampus, Eu preserved the synaptic structure against AβOs toxicity, maintaining stable levels of the presynaptic protein SV2 at the same concentration. Eu also averted synapsis failure from the AβOs toxicity by sustaining the frequencies of cytosolic Ca2+ transients. Finally, we found that Eu (30 nM) interacts with the Aβ aggregation process inducing a decrease in AβOs toxicity, suggesting an alternative mechanism to explain the neuroprotective activity of Eu.

Conclusion:

We believe that Eu represents a novel lead that reduces the Aβ toxicity, opening new research venues for lignans as neuroprotective agents.
A novel twin-support vector machines method for binary classification to imbalanced data
Authors: Li Jingyi , Chao Shiwei
Published: November 2022

Most existing classifiers are better at identifying majority classes instead of ignoring minority classes, which leads to classifier degradation. Therefore, it is a challenge for binary classification to imbalanced data, to address this, this paper proposes a novel twin-support vector machine method. The thought is that majority classes and minority classes are found by two support vector machines, respectively. The new kernel is derived to promote the learning ability of the two support vector machines. Results show that the proposed method wins over competing methods in classification performance and the ability to find minority classes. Those classifiers based-twin architectures have more advantages than those classifiers based-single architecture in classification ability. We demonstrate that the complexity of imbalanced data distribution has negative effects on classification results, whereas, the advanced classification results and the desired boundaries can be gained by optimizing the kernel.
Newbornscreening SMA – From Pilot Project to Nationwide Screening in Germany
Authors: Müller-Felber Wolfgang , Blaschek Astrid , Schwartz Oliver , Gläser Dieter , Nennstiel Uta , Brockow Inken , Wirth Brunhilde , Burggraf Siegfried , Röschinger Wulf , Becker Marc , Durner Jürgen , Eggermann Katja , Kölbel Heike , Müller Christine , Hannibal Iris , Olgemöller Bernd , Schara Ulrike , von Moers Arpad , Trollmann Regina , Johannssen Jessika , Ziegler Andreas , Cirak Sebahattin , Hahn Andreas , von der Hagen Maja , Weiss Claudia , Schreiber Gudrun , Flotats-Bastardas Marina , Hartmann Hans , Illsinger Sabine , Pechmann Astrid , Horber Veronka , Kirschner Jan , Köhler Cornelia , Winter Benedikt , Friese Johannes , Vill Katharina
Published: November 2022

Now that targeted therapies for spinal muscular atrophy are available, attempts are being made worldwide to include screening for spinal muscular atrophy in general newborn screening. In Germany, after pilot projects from 2018–2021, it was included in the general newborn screening from October 2021. To ensure a smooth transition, criteria for follow-up were developed together with key stakeholders. At the beginning of the transition to nationwide screening, false positive findings were reported in 3 patients. After optimization of the screening method in the laboratories concerned, all findings have been subsequently confirmed. On average, the first presentation to a neuromuscular center occurred on day 12 of life, and in patients with 2 or 3 SMN2 copies, therapy started on day 26 of life. Compared with the pilot project, there was no significant delay in timing.
Russia's Intangible Cultural Heritage as a Resource for Creating Touristic Offer
Authors:   Likhachyov Russian Cultural and Natural Heritage Research Institute, Putrik Iurii , . Solovyov Andrei ,   Likhachyov Russian Cultural and Natural Heritage Research Institute
Published: November 2022

The paper considers some issues concerning incorporation of intangible cultural heritage into a process of creating a competitive touristic offer, which is able to provide a stable contribution in sustainable social and economic development of a territory. The authors' views on a role of intangible cultural heritage in the context of elevation of attractiveness of tourist destinations at Russian domestic and incoming travel services market are outlined. The article gives many examples of successful popularization of some types of intangible cultural heritage that reflects ethnic and cultural diversity of the Russian state, including oral folk arts, intra-temple religious traditions, festive and ritual culture performing art, folk crafts, etc., in Russian touristic sector.
How to Think and Frame Third Worldism with Illustrations from Iran-South Africa Diplomatic Relations, 2006-2019
Authors: Onditi Francis
Published: November 2022

The historical relationship between Iran and South Africa dating to ancient times ignites flames of solidarity for countries that have suffered the predicament of global isolation and apartheid, respectively. However, there are long-standing fears that their common radical anti-imperial agenda of disrupting the structure of international order would isolate them further from the “thorax” of the global system to the periphery. It is not clear yet, the implications of this renewed geopolitical and geostrategic realignment on the contemporary world order on which that asymmetry seems to rest. I argue that the direction the Iran-South Africa partnerships will take in this renewed realignment depends largely on the ability of each side to manage the unequal political power dynamics that exist between the counterparts. On this note, I conclude by suggesting, the demand for reform within the aegis of the south-south solidarity, including, reframing the concept of Third Worldism will require the removal of the structural imbalances that more often frustrate the development of countries outside the “thorax.”
Native Aquatic and Wetland Plants: Duck Potato, Sagittaria lancifolia
Authors: Moore Kimberly A. , Fisher Luci E. , Della Torre Carl J. , Gettys Lyn A.
Published: November 2022

This 3-page fact sheet discusses the classification, description, habitat, propagation, and uses of duck potato, an aquatic perennial that typically grows in swampy ground or standing water in ponds, lakes, streams, and ditches and usually blooms in the spring. Written by Kimberly A. Moore, Luci E. Fisher, Carl J. Della Torre III, and Lyn A. Gettys, and published by the UF Department of Agronomy, December 2015.  
SS-AGR-399/AG403: Native Aquatic and Wetland Plants: Duck Potato, Sagittaria lancifolia (ufl.edu)
Plant Tissue Analysis and Interpretation for Vegetable Crops in Florida
Authors: Hochmuth G. J. , Maynard D. , Vavrina C. , Hanlon E. , Simonne E.
Published: November 2022

This guide is provided to assist vegetable growers, UF/IFAS Extension personnel, and consultants in conducting a meaningful plant tissue testing program. Guidelines are provided for collecting samples, proper handling of the sample, and choosing an analytical lab. Information is also presented on basic plant nutrition so that the reader understands the nutrient requirements of each vegetable crop and the process of identifying nutrient deficiencies.
The final section of the guide presents the deficiency, sufficiency, and toxicity ranges for plant nutrient concentrations. This is the interpretation portion. Values presented in the tables have been drawn from research from many areas of the country with emphasis on research conducted in Florida. Missing values in the tables indicate areas of research need. The final section of the guide also presents recommendations for nutrient deficiency correction. Originally published January 1991 and revised February 2004. This revision October 2012
Conservation Reserve Program: Overview and Discussion
Authors: Oh Juhyan , Guan Zhengfei
Published: November 2022

The Conservation Reserve Program, a governmental initiative with the goal of protecting the environment by retiring less productive but environmentally sensitive cropland from production, is by far the largest-scale, biggest-budgeted conservation program in the United States. The program has been a success, improving the land allocation of primary crop production and providing environmental benefits, but it is currently confronted with government budget cuts, and some farmers are reluctant to participate. This 5-page fact sheet provides an overview of the Conservation Reserve Program and discusses relevant issues for Florida. Written by Juhyun Oh and Zhengfei Guan, and published by the Food and Resource Economics Department, November 2015.
FE973/FE973: Conservation Reserve Program: Overview and Discussion (ufl.edu)
Preventing Foodborne and Non-foodborne Illness: Vibrio parahaemolyticus
Authors: Wright Anita C. , Goodrich Renée M. , Hubbard Michael A. , Schneider Keith R.
Published: November 2022

Vibrio parahaemolyticus is a naturally occurring bacterium that inhabits coastal brackish marine waters throughout the world and is commonly found in the United States and Canada. If ingested in sufficient numbers, this bacterium can cause illness such as gastroenteritis with symptoms such as cramps, vomiting, and nausea. Illnesses linked with this organism are usually associated with the consumption of raw or improperly cooked seafood, particularly raw oysters. This 3-page fact sheet is a major revision that discusses Vibrio parahaemolyticus, illness caused by the bacterium, factors that increase risk of infection, methods of infection, seafood and shellfish handling recommendations, and prevention. Written by Anita C. Wright, Renée M. Goodrich, Michael A. Hubbard, and Keith R. Schneider, and published by the UF Department of Food Science and Human Nutrition. Original publication date: July 2009. Revised: October 2015.  
FSHN0901/FS146: Preventing Foodborne and Non-foodborne Illness: Vibrio parahaemolyticus (ufl.edu)
Healthy Eating: Fluids
Authors: Bobroff Linda B.
Published: November 2022

More than one-half of an adult’s body weight is water. Water brings nutrients to the cells in our bodies and removes waste. Our bodies cannot function if they do not receive enough water. This 2-page fact sheet is a major revision that addresses the importance of water to physical functions, effects of dehydration, risk factors for dehydration in older adults, and fluid intake suggestions. Written by Linda B. Bobroff, and published by the UF Department of Family, Youth and Community Sciences, June 2016.
Get SMART: Improve Your Extension Objectives
Authors: Diehl David C. , Galindo-Gonzalez Sebastian
Published: November 2022

SMART Objectives assist educators and program planners in developing strong objectives that are Specific, Measurable, Achievable, Relevant and Time-bound. This 3-page fact sheet was written by David C. Diehl and Sebastian Galindo-Gonzalez, and published by the UF Department of Family, Youth and Community Sciences, June 2012. Revised September 2015.

FCS6018/FY1327: SMART Objectives (ufl.edu)
Postharvest Storage, Packaging and Handling of Specialty Crops: A Guide for Florida Small Farm Producers
Authors: Watson Jonathan Adam , Treadwell Danielle , Sargent Steven A. , Brecht Jeffrey K. , Pelletier William
Published: November 2022

Every year farmers must harvest their crops. This process marks the end of the growing season and carries social significance in communities, but it also creates challenges for producers trying to deliver fresh, high-quality produce to market. Good postharvest practices establish appropriate cold chains that maintain the correct temperatures, humidity, and respiration rates while also ensuring the safety, sanitation, and quality of the fruits. These postharvest practices differ, depending on the size and economic situation of an operation. This 18-page fact sheet provides postharvest storage, packaging, and handling recommendations for small farm specialty crop producers. Written by Jonathan Adam Watson, Danielle Treadwell, Steven A. Sargent, Jeffrey K. Brecht, and William Pelletier, and published by the Horticultural Sciences Department, October 2015.
HS1270/HS1270: Postharvest Storage, Packaging and Handling of Specialty Crops: A Guide for Florida Small Farm Producers (ufl.edu)
Water and Nutrient Management Guidelines for Greenhouse Hydroponic Vegetable Production in Florida
Authors: Hochmuth Robert C. , Parkell Natalie B. , Laughlin Wanda L. , Rider Sean C.
Published: November 2022

Many small farms are implementing greenhouse hydroponic systems. Perhaps the most challenging aspect of crop management for smaller growers is the control of water and nutrient delivery in a soilless media system. This 7-page fact sheet focuses on relatively inexpensive strategies to help small growers know both when to start irrigation events and how long to run a single event when growing in soilless media. Written by Robert C. Hochmuth, Natalie B. Parkell, Wanda L. Laughlin, and Sean C. Rider, and published by the Horticultural Sciences Department, December 2015.
HS1274/HS1274: Water and Nutrient Management Guidelines for Greenhouse Hydroponic Vegetable Production in Florida (ufl.edu)
Citrus Nutrition UF/IFAS Grower Trials
Authors: Vashisth Tripti , Burrow Jamie D.
Published: November 2022

Interested in learning more about citrus nutrition grower trials? This 2-page pamphlet provides information on the goals, objectives, benefits, and considerations of the trials, as well as specific information about trials being held from 2015-2017. The pamphlet also contains a sign up form for the trials. Written by Tripti Vashisth and Jamie D. Burrow, and published by the Horticultural Sciences Department, May 2016. Revised October, 2016.
Using Supplemental Lighting to Grow Hemp in Florida
Authors: Desaeger Johan , Coburn Jacqueline , Agehara Shinsuke
Published: November 2022

With the removal of hemp from the controlled substances list, hemp is now one of the emerging crops in Florida. There is limited information on how to grow this crop in Florida. Like hops, hemp is another recently introduced crop in the state, with one of the major yield-limiting factors of premature flowering induced by inadequate day length. This article provides guidelines for hemp growers in Florida on the use of supplemental lighting to control flowering and improve growth of hemp under Florida’s environmental conditions. Written by Johan Desaeger, Jacqueline Coburn, and Shinsuke Agehara, and published by the UF/IFAS Horticultural Sciences Department; 4 pp.https://edis.ifas.ufl.edu/hs1452
Do-It-Yourself Insect Pest Traps
Authors: Arthurs Steven , Hunsberger Adrian
Published: November 2022

Many types of traps can be used to monitor or control insect pests. Traps to capture insects vary greatly, depending on the target, location, and purpose. Traps may be inexpensive and disposable, or more complex. This 12-page fact sheet describes several traps for common pests in the home, garden, and landscape that can be made using common household materials or that are readily available in stores. Written by Steven Arthurs and Adrian Hunsberger, and published by the Entomology and Nematology Department, December 2015.
ENY-2030/IN1103: Do-It-Yourself Insect Pest Traps (ufl.edu)
Laurelcherry Smoky Moth, Neoprocris floridana Tarmann 1984 (Insecta: Lepidoptera: Zygaenoidea: Zygaenidae: Procridinae)
Authors: Hall Donald W.
Published: November 2022

This EDIS publication is an alternate version of a page published first on the Featured Creatures website. The Featured Creatures collection provides in-depth profiles of insects, nematodes, arachnids and other organisms relevant to Florida. These profiles are intended for the use of interested laypersons with some knowledge of biology as well as academic audiences. This 12-page fact sheet that discusses the laurelcherry smoky moth was written by Donald W. Hall, and published by the UF Entomology and Nematology Department, October 2015.

EENY634/IN1105: Laurelcherry Smoky Moth, Neoprocris floridana Tarmann 1984 (Insecta: Lepidoptera: Zygaenoidea: Zygaenidae: Procridinae) (ufl.edu)
Strawberry Leafroller Ancylis comptana (Frölich) (Insecta: Lepidoptera: Tortricidae)
Authors: Renkema Justin
Published: November 2022

This EDIS publication is an alternate version of a page published first on the Featured Creatures website. The Featured Creatures collection provides in-depth profiles of insects, nematodes, arachnids and other organisms relevant to Florida. These profiles are intended for the use of interested laypersons with some knowledge of biology as well as academic audiences. This 3-page fact sheet that discusses the strawberry leafroller was written by Justin Renkema, and published by the UF Entomology and Nematology Department, February 2016.

EENY644/IN1118: Strawberry Leafroller Ancylis comptana (Frölich) (Insecta: Lepidoptera: Tortricidae) (ufl.edu)
Hercules Beetle Dynastes hercules (Linnaeus, 1758) (Insecta: Coleoptera: Scarabaeidae)
Authors: Keller Oliver , Cave Ronald D.
Published: November 2022

This EDIS publication is an alternate version of a page published first on the Featured Creatures website. The Featured Creatures collection provides in-depth profiles of insects, nematodes, arachnids and other organisms relevant to Florida. These profiles are intended for the use of interested laypersons with some knowledge of biology as well as academic audiences. This 4-page fact sheet that discusses the Hercules beetle was written by Oliver Keller and Ronald D. Cave, and published by the UF Entomology and Nematology Department, July 2016.

EENY659/IN1142: Hercules Beetle Dynastes hercules (Linnaeus, 1758) (Insecta: Coleoptera: Scarabaeidae) (ufl.edu)
Pesticides: Routes of Exposure
Authors: Fishel Frederick M.
Published: November 2022

Pesticides can cause both short-term and long-term effects in humans. Human exposure to pesticides can happen through four major routes: through the mouth and digestive system, through the eyes, through the skin, or through the nose and respiratory system. This 2-page fact sheet explains each route of pesticide exposure, providing information on how to reduce the risk of pesticide exposure and hazard. Written by Frederick M. Fishel, and published by the Agronomy Department, December 2015.
Small Flock Poultry Nutrition
Authors: Davis Michael A.
Published: November 2022

Inadequate poultry nutrition results in substandard growth rates as well as decreased egg production and weight. In order to express the genetic potential for which they were selected, meat- and egg-type birds must receive the correct amounts of nutrients and energy through properly formulated rations. This 4-page fact sheet examines the roles of water, carbohydrates, proteins and amino acids, lipids (fats and oils), vitamins, minerals, and feed additives in poultry growth and development. It also emphasizes the importance of providing suitable feeds to birds of different ages and discusses common feeding mistakes. Written by Michael A. Davis, published by the UF Department of Animal Sciences, and reviewed and revised August 2015. This fact sheet is a major revision of “Small Poultry Flock Nutrition,” written by B. L. Damron and D. R. Sloan, April 1998. (Photo credit: Smather's Archives)
Lowering Soil pH to Optimize Nutrient Management and Crop Production
Authors: Mylavarapu Rao , Hochmuth George , Mackowiak Cheryl , Wright Alan , Silveira Maria
Published: November 2022

Because temperatures are relatively high and it rains a lot in the region, mineral soils in the southeastern United States tend to be naturally acidic. Managing soils for both pH and nutrients helps maintain soil fertility levels and ensure economic agricultural production. If they are not maintained in the 6.0 to 6.5 pH range, which is best for most crops, most mineral soils in the Southeast will gradually return to their natural acidic state and their fertility levels will drop. In order to keep the soil in the right range, farmers have been encouraged to make routine applications of lime. Calibrated lime requirement tests are part of standard soil tests in this region, but getting the balance right can be tricky. This 4-page fact sheet explains the factors that contribute to increased soil pH and describes methods for reducing soil pH that will reduce the chances of either under- or over-liming the soil. Written by Rao Mylavarapu, George Hochmuth, Cheryl Mackowiak, Alan Wright, and Maria Silevira and published by the Soil and Water Science Department, January 2016.
SL437/SS651: Lowering Soil pH to Optimize Nutrient Management and Crop Production (ufl.edu)
Integrating Critical Thinking into Extension Programming #4: Measuring Critical Thinking Styles Using the UFCTI
Authors: Lamm Alexa J.
Published: November 2022

The fourth installment in the Integrating Critical Thinking into Extension Programming series, this article explains the University of Florida Critical Thinking Inventory (UFCTI), a method of determining a person’s critical thinking style. This 3-page fact sheet describes the history and development of the UFCTI, how to interpret the results, and how to use the test to enhance Extension programs. Written by Alexa J. Lamm and published by the Department of Agricultural Education and Communication, April 2016.
AEC547/WC209: Integrating Critical Thinking into Extension Programming #4: Measuring Critical Thinking Styles Using the UFCTI (ufl.edu)
Strategies to Encourage Adoption of Stormwater Pond Best Management Practices (BMPs) by Homeowners
Authors: Ott Emily , Monaghan Paul , Wells Ondine , Hansen Gail , Warner Laura , Atkinson Michelle
Published: November 2022

Man-made ponds can be a useful way to collect, store, and treat stormwater runoff in residential areas. However, these ponds can become polluted when runoff contains fertilizers, pesticides, and pet waste from the neighborhood. This 9-page fact sheet outlines several best management practices (BMPs) for reducing stormwater pond pollution. Based on a survey of residents who live near stormwater ponds, the authors recommend strategies Extension educators can use to encourage residents to adopt these BMPs. Written by Emily Ott, Paul Monaghan, Ondine Wells, Gail Hansen, Laura Warner, and Michelle Atkinson, and published by the UF Department of Agricultural Education and Communication, July 2015.
Frequently Asked Questions about Evapotranspiration (ET) Irrigation Controllers
Authors: Monaghan Paul , Wells Ondine , Dukes Michael , Morera Maria , Warner Laura A.
Published: November 2022

Evapotranspiration is the amount of water that is released into the atmosphere through evaporation and plant transpiration. An evapotranspiration irrigation controller is a device that uses data about the landscape, the type of irrigation system, and local weather conditions to determine when and how much to irrigate. This 5-page fact sheet explains how the technology functions as well as how to install, program, operate, and maintain an ET controller for a money- and water-wise sustainable home landscape that’s lush and beautiful. Written by Paul Monaghan, Ondine Wells, Michael Dukes, Maria Morera, and Laura Warner, and published by the Department of Agricultural Education and Communications, November 2015.
Examining the Mediating Role of Self-compassion Between Communication Skills and Emotional Expression With the Empathy of Divorce Applicants
Authors:   Department of Psychology, Tehran Center Branch, Islamic Azad University, Tehran, Iran., Nazemi Zahra , Sepahmansour Mojgan ,   Department of Psychology, Tehran Center Branch, Islamic Azad University, Tehran, Iran., Mohammadkhani Parvaneh ,   Department of Psychology, Faculty of Psychology and Educational Sciences, Rehabilitation and Welfare University, Tehran, Iran., Tagiloo Sadegh ,   Department of Psychology, School of Rehabilitation, Astara Branch, Islamic Azad University, Rasht, Iran.
Published: November 2022

Objective: Given the prevalence of divorce and the growing trend of marital problems, it is necessary to investigate the factors that affect the interpersonal relationships of couples. Therefore, this study aims to investigate the mediating role of self-compassion in explaining the causal relationship between communication skills and emotional expression with empathy in divorce applicants. Methods: This was a descriptive-correlational study with path analysis. The statistical population consisted of all men and women who applied for a divorce (age range: 30-50) and were referred to the counseling centers of the Judiciary in Tehran City, Iran, during 2020-2021. The sample size included 396 cases and it was selected via the convenience sampling method. To collect the data, standard questionnaires of self-compassion, communication skills, couple empathy, and emotional expression were used. The data were analyzed using the SPSS software, v. 21, and AMOS v. 24. Results: The results showed the fitness of the model (comparative fit index=0.953, goodness of fit index=0.954, adjusted goodness of fit index=0.895 and root mean square error of approximation=0.082). The model explained about 34% of the variance of a couple’s empathy in divorce applicants. Conclusion: Based on these findings, the relationship between a couple’s empathy with communication skills and emotional expression is not a direct relationship and various factors, such as marital empathy can strengthen or weaken this relationship.
Designing of a Micropump System for Circulatory Support
Authors: Khaustov A. I. , Boyarsky G. G. , Krotov K. V.
Published: November 2022

Introduction. Support systems currently used in modern cardiac surgery to provide partial or complete, permanent or temporary replacement of cardiac function are frequently characterized by large dimensions, thus requiring major surgical interventions. Low invasiveness can be ensured by reducing the size of the implanted part of such systems, allowing these devices to be inserted through the femoral artery.

Aim. Development of a minimally invasive micropump system to support blood circulation.

Materials and methods. Based on the analysis of implementation of micropump circulatory support systems (MCSS), the configuration, operational principles and main components of such a system were determined. When designing a micropump, as a unit defining the weight and size parameters of the entire system, numerical and experimental methods were used to optimize its flow path based on the condition of minimizing blood injury and thrombus formation. The lubrication and cooling system was developed by solving the thermodynamic problem of heat removal. The electronic control unit was developed on the basis of accumulated experience in the design and operation of control units for circulatory support systems.

Results. A micropump with a diameter of 6.5 mm and a length of 43 mm with the required hydro- and hemodynamic parameters was designed. The device ensures minimal trauma and thrombus formation. The main MCSS parameters, as well as its main components (electric drives, lubrication and cooling systems), were defined. The configuration and operational principles of the electronic control unit (ECU), consisting in a microprocessor-based control system with feedback, were developed. The ECU built-in software manages the rotational speed of the electric drives of the micropump and coolant supply pump in the required range. In addition, the software is used to measure, display and register the MCSS operational parameters, as well as to monitor their operation in the required ranges and to exchange data between the ECU and the PC.

Conclusion. All the necessary documentation for the MCSS nodes and components was prepared. These nodes and components ensure the hydro- and hemodynamic parameters required for the use of the developed minimally invasive micropump system. Future work will address the stages of MCSS assembly and debugging.
Rapid Numerical Calculation of Rayleigh Surface Acoustic Wave Parameters for a Model of Coupling Modes
Authors: Koigerov A. S. , Balysheva O. L.
Published: November 2022

Introduction. Mathematical modeling is the most important stage in the development of devices based on surface acoustic waves (SAW). Computer simulations that have proven their efficiency in recent years can significantly reduce the time input and improve the accuracy of calculating the designed characteristics. A rapid analysis of the operating characteristics of the designed acoustoelectronic devices requires the knowledge of basic parameters of acoustic waves propagating along the device substrates.  

Aim. Proposal and approbation of a methodology for calculating the key parameters necessary for modeling SAW devices based on the models of P-matrix and coupling modes, based on the example of analysis of Rayleigh waves by the finite element method.  

Materials and methods. The theoretical part of the work was carried out using the mathematical theory of differential equations presented in a matrix form and the finite element method. Mathematical processing was conducted in the MatLab and COMSOL environments.  

Results. An original technique for deriving SAW parameters for a model of coupling modes based on a rapid algorithm implemented in COMSOL was developed. A comparison of the calculated parameters of electromechanical coupling coefficient and velocity of acoustic waves over the substrate surface with those presented in literature showed their good agreement. Based on the derived parameters, a number of transversal filters were designed. A comparison of the calculated and experimentally measured values of the transmission coefficient was performed.  

Conclusion. The proposed technique for analyzing infinite periodic electrodes by the finite element method based on an analysis of eigenfrequencies and static analysis made it possible to calculate the main parameters of Rayleigh waves in conventional substrates: lithium niobate, lithium tantalate and quartz. The practical significance lies in the use of the obtained parameters in the development of various classes of acoustoelectronic devices.
THE IMPACT OF THE RUSSIAN AGGRESSION AGAINST UKRAINE: UNCERTAINTY, INSECURITY AND FEAR OF THE ENERGY POLICY IN THE FACE OF WAR AND THE CONSEQUENCES OF WAR
Authors: Tomljenović Marija , Srdoč Marina
Published: November 2022

On February 24, 2022, Russia, led by Putin, destroyed the European world peace by a military attack on Ukraine under the pretext that Ukraine poses a constant threat to Russia, hindering the development of Russia and its existence. The Russian invasion of Ukraine, which for Putin is a fiction “about a special military operation”, has greatly affected energy security around the world and provoked uncertainty in the field of energy policy both in Europe and in the world. The authors of this paper do not intend to present their final judgment and outcome on this issue, especially for the reason that the situation in the field of energy policy changes from day to day. However, the authors want to contribute to better understanding of this problem in terms of what can be expected in the future. This involves the measures necessary to achieve energy security, including independence from Russian gas. In addition, it can be assumed that after the introduction of Western sanctions against Russia, Putin manipulates and uses energy policy as his political weapon.
Pengkaryaan Santri Anak Usia Dini di Pesantren Tahfidz Al-Ishlah Pati Dalam Perspektif Undang-Undang Perlindungan Anak
Authors: Rosyid Moh , Kushidayati Lina
Published: November 2022

Islamic boarding schools as institutions that cadre scientists (ulama) to understand Islamic science for the provision of society. However, socializing also requires expertise as a source of livelihood, so students are also equipped with skills with real daily practice (entrepreneurship). The problem in this study, namely how to divide activities between study time and work at the Tahfidz al-Islah Islamic Boarding School, and where is the point of vulnerability to violations of the Child Protection Act. The purpose of this study was to describe learning at the Tahfidz Al-Ishlah Islamic Boarding School in Kadilangu Village, Trangkil District, Pati Regency, Central Java. Data was obtained in 2020 with interviews, observations, and literature which were analyzed descriptively qualitatively. The results of the study found that the pesantren for prospective al-Quran memorizers provided knowledge about fiqh, interpretation of the Koran, and entrepreneurship facilitated by Islamic boarding schools. Compensation obtained by students in addition to knowledge is free of charge for education, boarding, and meals. Entrepreneurship education is taught from an early age as an effort to cultivate the character of an entrepreneurial spirit and train students' independence. In its application there are no violations of the Child Protection Act.
Katekese Untuk Membangkitkan Antusias dan Keaktifan OMK Paroki Maria Bunda Karmel, Probolinggo
Authors: Budiono Ignasius , Sihotang Juli Antonius , Firmanto Antonius Denny
Published: November 2022

This paper departs from the author's anxiety to see the lack of enthusiasm and activeness of young people, especially the MBK parish OMK organization, Probolinggo in participating in church activities. The author collects data from the database of parishioners (the total number of young people), answers to questions on google forms, and the author's experience when he was one of the supervisors of OMK, Probolinggo. All the data collected were then analyzed using a qualitative-descriptive method. The author will show the results of the research based on the data that has been obtained through the MBK parish, various answers from young members of OMK, and the author's own observations. Through these data, it was found that there were gaps within the organization itself, and the time mismatch of existing activities with their respective statuses and activities. Not yet compact, lack of enthusiasm, and the activeness of OMK members is what then makes many young people in MBK parish not interested in becoming OMK members. Based on the formulation of the existing problems and the findings, it can be concluded that good, in-depth, and sustainable catechesis is very influential for young people to create cohesiveness in the OMK organization, so that they respect each other, relate closely, and are full of brotherhood with one another.
Planning Framework dan Outline Model Imajinasi Kreatif Berbasis Neurosains (IKBN) Pada Pembelajaran Keagamaan Islam Tingkat Sekolah Dasar
Authors: Yusmaliana Desfa , Suyadi Suyadi , Widodo Hendro , Zakaria Gamal Abdul Nasir
Published: November 2022

Imajinasi kreatif merupakan salah satu fungsi otak intuitif yang selama ini belum banyak dipelajari, sehingga pemikiran imajinatif sering kali dikesampingkan, bahkan didiskreditkan. Padahal, para Ulama dan Ilmuan terdahulu tidak jarang yang menggunakan imajinasi kreatifnya dalam proses penciptaaan teori baru. Oleh karena itu, diperlukan model kajian otak intuitif—yang selama ini dipelajari di bidang neurosains—sebagai basis berpikir imajinasi kreatif. Penelitian ini menggunakan pendekatan deskriptif kualitatif. Pengumpulan data dilakukan dengan teknik analisis konten dan wawancara Kajian ini selanjutnya disebut dengan istilah “Model Imajinasi Kreatif Berbasis Neurosain (IKBN). Agar model ini dapat dioperasionalisasikan dalam pembelajaran keagamaan Islam, perlu diberikan planning framework dan outline pembelajaran. Model IKBN dirancang dengan menggunakan beberapa alat pembelajaran yang dikenal dengan alat kognitif atau neurosains kognitif. Sebagian besar spesifikasi metode yang terdapat pada model IKBN memiliki hasil yang mirip dengan cognitive tools yang dikonsepkan oleh Kieran Egan, namun lebih spesifik ditujukan pada mata pelajaran keagamaan Islam pada jenjang sekolah dasar.
PUBLIC SERVICE FIVE-FINGER HYPNOSIS THERAPY IN FACING ANXIETY IN ELEMENTARY SCHOOL CHILDREN AT SDN 43 PEKANBARU
Authors: Rahmaniza Rahmaniza , Nadia Fatma , Mianna Rika
Published: November 2022

Corona Virus Disease 2019 (Covid-19) is a pandemic because all countries in the world have been affected by this outbreak so it has an impact on various aspects of life such as the economy, health, and education. Five-finger hypnosis is a form of self-hypnosis that can cause a high relaxation effect that will reduce tension and anxiety in a person's mind so that it affects the production of hormones that can spur the onset of anxiety. Schoolchildren have never had Five-finger Hypnosis Therapy at school, Covid 19 conditions schoolchildren learn online and only focus on subjects. The new normal condition of learning time alternately some enter the morning and some enter the afternoon, if not given Five finger Hypnosis Therapy then the child is less able to face anxiety. The main problem faced by partners is SDN 43 Pekanbaru, namely that its students have never been given five-finger hypnosis therapy, so five-finger hypnosis therapy will be carried out in the face of anxiety in school children. Before and after the activity, an assessment of the initial and final abilities of the participants will be carried out, so that from this activity a measurable increase in knowledge will be obtained. The majority of respondents with moderate anxiety were 33 respondents (57.9 %). the majority of respondents with moderate anxiety were 31 respondents (54.4 %). there is an influence of PKM Five Finger Hypnosis Therapy in Dealing with Anxiety in Elementary School Children at SD Negeri 43 Pekanbaru on pre-test and post-test.
ISLAMIC BOARDING SCHOOL BUSINESS UNIT BUSINESS MANAGEMENT INNOVATION THROUGH DIGITIZING BUSINESS AND FINANCE
Authors: Ahmad Faisal Yudi , Arum Kanti Runita , Alamanda Amelia Rizky
Published: November 2022

This service activity aims to help pesantren to be better in their education prepare financial reports so that accountability and responsibility of the reports finances can be better accounted for to the public pesantren to preparation of financial statements based on Islamic boarding school accounting standards. Other purposes of This activity is to provide direction to pesantren administrators so that they can be more efficiently manage pesantren finances. Partner locations are in West Java and webinars carried out online. The results of the service show that 100% of the participants have never attend similar training.
Closed Form Solution to an Optimal Control Problem by Orthogonal Polynomial Expansion
Authors: Tavallaei Ali , Tousi Behrouz
Published: November 2022

In this study the use of orthogonal polynomials for obtaining a close form solution to optimal control problems with a weighed quadratic cost function, is proposed. The method consists of using the Orthogonal Polynomials for the expansion of the state variables and the control signal. This expansion results in a set of linear equations, from which the closed form solution is obtained. A numerical example is provided to demonstrate the applicability and effectiveness of the proposed method.
Remote care in UK general practice: baseline data on 11 case studies
Authors: Greenhalgh Trisha , Shaw Sara E. , Alvarez Nishio Anica , Byng Richard , Clarke Aileen , Dakin Francesca , Faulkner Stuart , Hemmings Nina , Husain Laiba , Kalin Asli , Ladds Emma , Moore Lucy , Rosen Rebecca , Rybczynska-Bunt Sarah , Wherton Joseph , Wieringa Sietse
Published: November 2022

Background: Accessing and receiving care remotely (by telephone, video or online) became the default option during the coronavirus disease 2019 (COVID-19) pandemic, but in-person care has unique benefits in some circumstances. We are studying UK general practices as they try to balance remote and in-person care, with recurrent waves of COVID-19 and various post-pandemic backlogs.

Methods: Mixed-methods (mostly qualitative) case study across 11 general practices. Researchers-in-residence have built relationships with practices and become familiar with their contexts and activities; they are following their progress for two years via staff and patient interviews, documents and ethnography, and supporting improvement efforts through co-design. In this paper, we report baseline data.

Results: Reflecting our maximum-variety sampling strategy, the 11 practices vary in size, setting, ethos, staffing, population demographics and digital maturity, but share common contextual features—notably system-level stressors such as high workload and staff shortages, and UK’s technical and regulatory infrastructure. We have identified both commonalities and differences between practices in terms of how they: 1] manage the ‘digital front door’ (access and triage) and balance demand and capacity; 2] strive for high standards of quality and safety; 3] ensure digital inclusion and mitigate wider inequalities; 4] support and train their staff (clinical and non-clinical), students and trainees; 5] select, install, pilot and use technologies and the digital infrastructure which support them; and 6] involve patients in their improvement efforts.

Conclusions: General practices’ responses to pandemic-induced disruptive innovation appear unique and situated.  We anticipate that by focusing on depth and detail, this longitudinal study will throw light on why a solution that works well in one practice does not work at all in another. As the study unfolds, we will explore how practices achieve timely diagnosis of urgent or serious illness and manage continuity of care, long-term conditions and complex needs.
Casa del Ron Varadero: Evaluación como producto turístico
Authors: González Cuesta Orlando de la C , Cruz Martínez Annalye
Published: November 2022

El trabajo se propone estudiar la evolución que ha tenido un producto extra -hotelero hasta posicionarse como un atractivo turístico integrado en las ofertas opcionales en el destino de Varadero. La evaluación incluye una valoración de los factores internos y del entorno que influyen en el desarrollo estratégico del producto. Un propósito fundamental del trabajo es demostrar la importancia de productos extra -hoteleros de esa naturaleza en el fortalecimiento del atractivo y la sostenibilidad del destino, más allá del conglomerado de instalaciones de alojamiento de alto estándar con un diseño inclusivo. En el trabajo se utilizan mapas cognitivos difusos para abordar el problema de por sí no estructurado y difícilmente cuantificable. Se recurre a las opiniones de expertos, incluidos los autores del trabajo.
e-Klinik: Prototipe Sistem Layanan Klinik Gigi di Masa Pandemi Covid 19
Authors: Sidik Rangga , Fadhlurrahman Muhammad Alfi
Published: November 2022

The implementation of health protocols during the Covid-19 pandemic had an impact on health service activities in dental clinics. Arrangements to keep distance and avoid crowds are important points in the implementation of dental health services for the community. The e-clinic system provides an alternative solution to assist dental health service workers in carrying out the administrative process and for doctors who diagnose patients through the use of web technology. This study made with the aim of analyzing and designing an e-clinic system to help dental clinic services during the Covid-9 pandemic. To get research results that suit its needs, the case study method is used with the application of prototype system development through an object-oriented systems approach. Modeling uses UML (unified modeling language) tools and testing is done using a black box. E-clinic models and system prototypes are the results of research conducted. The e-clinic system that was built is expected to make it easy for the community to get dental health services in clinics by implementing well-maintained health protocols.
Development of Suppositories Silicone Molds Using Additive Technologies
Authors: Gusev K. A. , Terenteva O. A. , Maimistov D. N. , Generalova Yu. E. , Sidorov K. O. , Flisyuk E. V.
Published: November 2022

Introduction. In modern practice, suppositories are prepared by hand rolling method or fusion. 3D printing can overcome the disadvantages of traditional suppository manufacturing methods and solve the problems of personalization. 3D printing makes it possible to manufacture drug-loaded suppositories without the use of molds or other physical support. The current studies have a number of limitations, and the printing of one suppository requires a long time. This report proposes a method of 3D modeling and 3D printing to produce personalized suppositories by fusion.

Aim. Various sizes and shapes suppositories silicone molds development by molding method from hydrophilic, lipophilic and amphiphilic bases.

Materials and methods. Suppository bases: cocoa butter (Luker, Colombia), polyethylene glycol (PEG) 1500 (Merck KGaA, Germany), PEG-400 (Merck KGaA, Germany), Witepsol H-15 (Chimmed Group, Russia); pharmaceutical substance: paracetamol (Hebei Jiheng (Group) Pharmaceutical Co. Ltd, China); filaments for 3D printing: polyethylene terephthalate (PET-G natural, LLC "PrintProdakt", Russia); silicone two-component platinum, hardness Shore 30A (China); solvents: Acetonitrile Grade HPLC (Merck KGaA, Germany). The design of the both casting and master molds of suppositories was carried out using the KOMPAS-3D version 17.1. Master molds were printed by Picaso PRO 250 and Picaso X Pro 3D printers. Mold segments were obtained by filling master molds with a mixture of two-component silicone. Suppositories were obtained by molding method. Their average weight and standard deviation were determined. Paracetamol concentration in suppositories was carried out by UV spectrophotometry on a UV-1240 mini spectrophotometer (Shimadzu, Япония). Silicone molds were soaked and washed in hot water with surfactants. Washouts from the molds were taken by soaking the mold.

Results and discussion. The torpedo-shaped form was chosen as the model form of suppositories. For the chosen form, three volumes of suppositories were designed: 3.32 ml; 1.5 ml and 0.25 ml. Silicone molds were designed and manufactured for all volumes. The cast suppositories were examined for compliance with the regulatory documentation for the dosage form, the average weight and mass uniformity were evaluated. Suppositories with paracetamol were made. A procedure for cleaning the obtained silicone molds has been developed.

Conclusion. The resulting silicone molds make it possible to obtain suppositories in accordance with the regulatory documentation for the suppositories. Silicone molds have significant advantages compared to analogues of metal or polymeric molds.