bluuebunny/crossref_metadata_2025 huggingface dataset:
The Influence of Audit Costs, Audit Engagement and Audit Rotation on Audit Quality
Authors: Fauziyah Nurul , Darmayanti Novi
Published: May 2021

This study aims to determine the relationship between audit costs, audit engagement, audit rotation on audit quality in textile and garment manufacturing companies listed on the Indonesia Stock Exchange in 2013-2017. The research method used a quantitative approach, while the data source used was secondary data. The study population was 16 companies in the textile and garment subsector manufacturing companies listed on the Indonesia Stock Exchange for the period 2013-2017. The sampling method is purposive sampling method, namely the technique of determining the sample with certain considerations. The method of analysis uses multiple linear regression analysis. Partially, it shows that audit costs have a significant effect on audit quality, while engagement auditing has no effect on audit quality, and audit rotation has no significant effect on audit quality. Simultaneously, audit cost, audit engagement and audit rotation have a significant effect on audit quality.
The Effect of The Existence of Internal Audit Function and Internal Audit Disclosure
Authors: Asri Putri Retno , Muhammad Erfan
Published: May 2021

This study aims to examine and analyze the effect of the existence of an internal audit function (IAF) and internal audit disclosure (DIA) on external audit fees in non-financial companies listed on the Indonesia Stock Exchange in 2015-2019. The approach used in this study is a quantitative study consisting of 327 samples with purposive sampling technique. Data analysis in this study using multiple linear regression. The results showed that the existence of the internal audit function (IAF) had a negative and insignificant effect on the audit fee service, while the disclosure of the Internal Audit (DIA) had a significant positive effect on the fee service audit. Control variables, namely company size, return on assets, public accounting firms and subsidiaries are used to avoid it bias element.
A step Towards Environmental Mitigation In South Africa: Does Trade Liberalisation Really Matter? Fresh Evidence From A Novel Dynamic ARDL Simulations Approach
Authors: Udeagha Maxwell Chukwudi , Ngepah Nicholas N
Published: May 2021

This study revisits the trade-CO2 emissions nexus for South Africa over the period 1960–2016. Our strategy is distinctively different from previous works in the following dimensions: we employ the recently developed novel dynamic autoregressive distributed lag (ARDL) simulations framework to examine the negative and positive changes in trade openness, technological innovation, industrial growth, energy consumption, foreign direct investment, technique effect, and scale effect on CO2 emissions. Second, we use an innovative measure of trade openness developed by Squalli and Wilson (2011) to capture trade share in GDP as well as size of trade relative to world trade for South Africa. Third, we use the frequency domain causality (FDC) approach, the robust testing strategy suggested by Breitung & Candelon (2006) which enables us to explore permanent causality for medium, short and long-term relationships among variables under review. Fourth, we employ the second-generation econometric procedures accounting robustly the multiple structural breaks which have been considerably ignored in earlier studies. For South Africa, we find that: (i) higher trade openness is strikingly injurious to the environment in the long run, although it is environmentally friendly in the short run; (ii) the scale effect increases CO2 emissions whereas the technique effect improves it, validating the presence of an environmental Kuznets curve (EKC) hypothesis; (iii) energy consumption, foreign direct investment and industrial value-added deteriorate environmental quality; (iv) technological innovation contributes to lower CO2 emissions; (v) the pollution haven hypothesis (PHH) exists; (vi) InSE, InTE, InOPEN, InEC, InFDI, InTECH and InIGDP Granger-cause InCO2 in the medium, long and short run suggesting that these variables are important to influence CO2 emissions. In light of our empirical evidence, this paper suggests that the international teamwork to lessen carbon emissions is immensely critical to solve the growing trans-boundary environmental decay and other associated spillover consequences.JEL Classifications: F18, F13, Q56; O13; F1; F41
Delineation of Groundwater Potential Zone Through Geospatial Technique, Multi-Criteria Decision Analysis, And Analytical Hierarchy Process
Authors: Srivast Sunil Kumar
Published: May 2021

Study Region: This study area is located in a subtropical semi-arid climatic zone of India, suffering due to the low availability of water. Hence, delineation of the groundwater potential zone (GWPZ) had performed through the geospatial technique, the multicriteria decision analysis (MCDA), and the analytical hierarchy process (AHP). Study Focus: The thematic-layers of the geology, geomorphology, soil types, lineament-density, the slope of the topography, drainage-density, land-use, and land-cover developed and created by utilizing available supplementary data and digital satellite images. GWPZ had classified into 5 classes like excellent, good, moderate, poor, and very-poor. The summary of the methodology adopted for the delineation of GWPZ has given in fig-2.New Hydrological Insights for the Region: It had observed that the consistency index (CI) was 0.0106, while the random index (RI) for 7 variables considered from standard tables is 1.32. The calculated consistency ratio (CR) in this study was 0.0080 lower than 0.1000. This low CR indicated moderate consistency in the results of pairwise comparisons among the thematic layers assigned weight for analysis. Hence, the AHP model used for this research work has shown reasonably good accuracy. The statistics of GWPZ indicated ~3.97% of study-area possessed excellent GWPZ, ~37.09% very-good, ~41.72% moderate, ~15.23% poor, and ~1.99% very-poor. This model of the GWP map shows that the Area Under the Curve (AUC) of the Receiver Operating Characteristic Curve (ROC) is ~0.726. It indicated good agreement between experimental results and predicted results.
Comparative Analysis of Pan-cancer and Normal Tissues Reveals Cancer Tissue-enriched CircRNAs Associated with Cancer Mutations as Potential Exosomal Biomarkers
Authors: Wang Xuezhu , Dong Yucheng , Wu Zilong , Wang Guanqun , Shi Yue , Zheng Yongchang
Published: May 2021

Background: A growing body of evidence has shown that circular RNAs (circRNAs) are promising exosomal cancer biomarker candidates. However, global alterations of circRNAs in cancer and the driving force of circRNA biogenesis remain under investigation. Studies on these factors are needed to identify ideal circRNA biomarkers for cancer.Methods: We comparatively analyzed the circRNA landscape in pan-cancer and normal tissues to investigate their biologically significant characteristics and identify circRNAs enriched in pan-cancer. We used co-expression analysis, LASSO regularization, and support vector machine to analyze 265 pan-cancer and 319 normal tissues to identify circRNAs with the highest ability to distinguish cancer tissues from normal tissues which showed high expression in plasma exosomes from patients with cancer (e.g., hepatocellular carcinoma, HCC) and were associated with cancer mutations. Results: Expression of circRNAs was reduced in cancer tissues and plasma exosomes from patients with cancer than in normal tissues and exosomes from healthy controls. The circRNAs with the strongest ability to distinguish between cancer and normal tissues were among the top 10% of stably expressed circRNAs. Compared with normal-tissue-enriched circRNAs, cancer-tissue‒enriched circRNAs exhibited a more prominent association with cancer mutations and higher levels in plasma exosomes from patients with HCC. Particularly, we identified dynein axonemal heavy chain 14 (DNAH14), which serves as the host gene of three cancer tissue-enriched circRNAs, as one of the top back-spliced genes exclusive to cancer tissues. Among these three circRNAs, chr1_224952669_224968874_+ was significantly elevated in plasma exosomes from patients with HCC and was associated with the cancer mutation chr1:224952669: G>A, a splice acceptor variant that is potentially a driving force of circRNA biogenesis.Conclusions: Our bioinformatic analyses provide insights into the characteristics of the circRNA landscape in cancer and the potential of cancer mutation-associated and cancer tissue-enriched RNAs as plasma exosomal cancer biomarkers. Moreover, our results highlight DNAH14 as a host gene that should be further examined in studies of circRNA in cancer.
Green Synthesis of Zinc Oxide Nanoparticles Loaded on Activated Carbon Prepared From Walnut Peel Extract for the Removal of Eosin Y and Erythrosine B Dyes From Aqueous Solution: Experimental Approaches, Kinetics Models and Thermodynamic Studies
Authors: Rashtbari Yousef , Afshin Shirin , Hamzezadeh Asghar , Gholizadeh Abdolmajid , Ansari Farshid Jaberi , Poureshgh Yousef , fazlzadeh mehdi
Published: May 2021

Water contamination due to release of dye containing effluents is one of the environmental problems of serious concern today. The present study investingate the Green synthesis of zinc oxide nanoparticles (ZnO-NPs) doped on activated carbon (AC) prepared from walnut peel extract and to estimate its efficiency in the removal of Eosin Y (Eo-Y) and Erythrosine B (Er-B) from its aqueous solution. The synthesized AC-ZnO was identified by field emission scanning electron microscopy (FE-SEM), X-ray diffraction (XRD) and the Brunauer–Emmett–Teller (BET). The influence of various parameters such as pH, dosage of AC-ZnO, contact time, and concentrations of Eo-Y and Er-B were also studied. The pH 3 was observed as the optimum pH while the equilibrium was noticed to reach in 30 min at dosage of 1 g/L and initial concentration 100 mg/L for Eosin Y and Erythrosine B adsorption onto AC-ZnO. The maximum adsorption capacity of Eo-Y and Er-B onto AC-ZnO was found to be 163.9 and 144.92 mg/g (and removal efficiencies of 95.11 and 98.31 %), respectively. The process of Eo-Y and Er-B adsorption on AC-ZnO was observed to be depended on the pseudo-second-order kinetic model which indicate chemisorption processes. Langmuir adsorption isotherm model test described the removal of Eo-Y and Er-B on AC-ZnO. The Eo-Y and Er-B adsorption were found to be non-spontaneous and endothermic in nature. Also, the values, SBET and VTOTAL for the AC-ZnO were equal to 725.65 m2/g and 0.6004 cm3/g, respectively. The results of this study exhibited that AC-ZnO was a very effective method that can be used for the removal of Eo-Y and Er-B from aqueous solutions.
ATG101 as a Novel Prognostic Biomarker Related to Immunotherapy in Pan-cancer
Authors: Zhang Zijian , Mo Jinggang , Jin Chong , Jiang Hao , Liu Zhongtao , Zou Heng , Xiong Li , Teng Chuang , Wen Yu , wang Kunpeng
Published: May 2021

Background: ATG101 plays a significant role in the occurrence and development of tumours by regulating autophagy. Our study aimed to research the correlation between the expression of ATG101 and tumour prognosis and its role in tumour immunity. Methods: First, integrated analysis of The Cancer Genome Atlas and Genotype-Tissue Expression portals were used to analyse the expression of ATG101. Then, we used Kaplan–Meier curves for survival analysis. Next, we analysed the relationship between ATG101 expression and six immune cells, the immune microenvironment and immune checkpoints. Besides, we analysed the relationship between the expression of ATG101 and methyltransferase. Finally, we used GSEA to study the function of ATG101 in COAD and LIHC. Results: Integrated analysis showed that ATG101 was overexpressed in different tumours. Kaplan–Meier curves found that ATG101 was associated with poor prognosis in most tumours. We found that that ATG101 can be used as a target and prognostic marker of tumour immunotherapy for different tumours. We also found that ATG101 regulates DNA methylation. GSEA analysis showed that ATG101 may play a critical role in COAD and LIHC.Conclusions: Our study highlights the significance of ATG101 in the study of tumour immunity from a pan-cancer perspective.
Beyond Private 5G Networks: Applications, Architectures, Operator Models and Technological Enablers
Authors: Maman Mickael , Strinati Emilio Calvanese , Dinh Lam Ngoc , Haustein Thomas , Keusgen Wilhelm , Wittig Sven , Schmieder Mathis , Barbarossa Sergio , Merluzzi Mattia , Costanzo Francesca , Sardellitti Stefania , Klessig Henrik , Kendre Savita Vitthalrao , Munaretto Daniele , Centenaro Marco , Pietro Nicola di , Liang Shuo-Peng , Chih Kuan-Yi , Luo Jack Shi-Jie , Kao Ling-Chih , Huang Jiun-Cheng , Huang Jen-Sheng , Wang Tzu-Ya
Published: May 2021

Private networks will play a key role in 5G and beyond to enable smart factories with the required better deployment, operation and flexible usage of available resource and infrastructure. 5G private networks will offer a lean and agile solution to effectively deploy and operate services with stringent and heterogeneous constraints in terms of reliability, latency, re-configurability and re-deployment of resources as well as issues related to governance and ownership of 5G components, and elements. In this paper we present a novel approach to operator models, specifically targeting 5G and beyond private networks. We apply the proposed operator models to different network architecture options and to a selection of relevant use cases offering mixed private-public network operator governance and ownership. Moreover, several key enabling technologies have been identified for 5G private networks. Before the deployment, stakeholders should consider spectrum allocation and on-site channel measurements in order to fully understand the propagation characteristic of a given environment and to set up end-to-end system parameters. During the deployment, a monitoring tools will support to validate the deployment and to make sure that the end-to-end system meet the target KPI. Finally, some optimization can be made individually for service placement, network slicing, network orchestration or jointly at RAN, MEC or core network level.
Plastic Bronchitis Associated With Influenza a Virus in a Child With Nephrotic Syndrome
Authors: Maehara Kenji , Kurokawa Mari , Tezuka Junichiro , Lee Sooyoung , Kaku Yoshitsugu
Published: May 2021

BackgroundPlastic bronchitis (PB) combined with nephrotic syndrome (NS) is rare, and the pathophysiological relationship between PB and NS has not been elucidated. We report a case of an 8-year-old boy with life-threatening PB caused by an influenza infection during a relapse of NS. Case presentationThe patient was on immunosuppressive drugs for NS. He developed fever due to an influenza A virus infection, followed by respiratory distress and frequent vomiting. Prednisolone was administered for possible bronchial asthma and NS. His respiratory status deteriorated rapidly, which required ventilator management. A large mucus plug was aspirated using bronchoscopy. He was then diagnosed with PB caused by the influenza A virus. Increased lower airway secretion and fluid leakage into the airways by relapse of NS were considered the causes of mucus plug formation. Besides, the decreased circulating blood volume might have made the bronchial secretions viscous with cast formation.ConclusionsPediatric patients with NS may be at a higher risk of developing PB. As PB is a life-threatening condition, patients with NS should be closely monitored when simultaneously infected with influenza virus.
Distinct Ecological Adaptations and Habitat Responses to Future Climate Change in Three East and Southeast Asian Sapindus Species
Authors: Liu Jiming , Xu Yuanyuan , Sun Caowen , Wang Xin , Zheng Yulin , Shi Shuanglong , Chen Zhong , He Qiuyang , Weng Xuehuang , Jia Liming
Published: May 2021

Background: Sapindus is an important biodiesel, biomedical, and multifunctional economic forest species in Asia, however its germplasms have been persistently damaged or lost. It is imperative to conserve the diversity of Sapindus. This study aimed to reveal the potential habitat distribution patterns of Sapindus mukorossi, Sapindus delavayi, and Sapindus rarak in response to current environment and future climate change, and identify hotspots of habitat degradation/expansion to facilitate climate change-adaptive biological conservation. Methods: Using current environmental data and future climate projections (2021–2100), we simulated the present and potential future habitats of Sapindus mukorossi, Sapindus delavayi, and Sapindus rarak in east and southeast Asia using a maximum entropy (MaxEnt) model that was developed based on 2041 occurrence records. Results: The model showed that precipitation may play an important role in framing the potential habitats of Sapindus; however, S. delavayi was more sensitive to minimum temperatures (-2 °C to 3 °C) and elevation (1200-2000 m), while S. rarak was more demanding in terms of solar radiation (annual mean Uvb of 4600 to 5000 J/m2/day). Under the current environment, S. mukorossi has the widest suitable habitat distribution (250.24 × 104 km2), followed by that of S. rarak (173.49 × 104 km2), and S. delavayi (78.85 × 104 km2). Under future climate change scenarios, the habitat distribution of S. mukorossi will expand and contract, that of S. delavayi exhibited significant expansion. In contrast, future S. rarak habitat distribution exhibited significant contraction. Conclusions: There were significantly distinct ecological adaptations among Sapindus mukorossi, Sapindus delavayi, and Sapindus rarak in east and southeast Asia. The contraction areas should be subject to germplasm collection and ex situ conservation preferentially. The modelled unchanged areas should be used for potential future Sapindus mukorossi, Sapindus delavayi, and Sapindus rarak conservation and utilization.
Land Cover Changes Implications in Energy Flow and Water Cycle in São Francisco Basin, Brazil, over the Past Seven Decades
Authors: Santos Vitor Juste dos , Calijuri Maria Lúcia , de Assis Leonardo Campos
Published: May 2021

This research aimed to quantify and qualify alterations in land cover and verify the implications of these modifications for variables related to energy flows and water cycle in São Francisco basin (SFB), located entirely in Brazilian territory, in the second half of the 20th century and beginning of the 21st. For this, statistical analyzes (descriptive, trends, seasonal and correlations) were used to quantify changes in the variables of land cover and energy/water flows, in addition to relating them. As a result, it was found that the SFB lost 65,680 km² of native vegetation (10.4% of basin area) to crops and pastures, reducing water infiltration (-52%) while the rains remained stable (-2%). Water loss increased through evapotranspiration (+5%) and surface runoff (+225%). Such changes in the water cycle have entailed an 11% reduction in São Francisco river long term flow rate (Q95), comparing pre and post-1990s period. In SFB, the activities that required water, such as farming activities, are those that promote hydric loss.
Deep genome sequencing provides potential novel insights into plateau adaptations in domestication of goats to extreme environments
Authors: Tian Dehong , Zhou Baicheng , Han Buying , Liu Sijia , Tian Fei , Qi Delin , Zhao Kai
Published: May 2021

Background: Environmental conditions and extensive rearing impose a myriad of selective pressures on domesticated animals living at high altitude. These pressures have selected for the characteristics of strong adaptability for life in the alpine pastoral area. While it is accepted that various natural and anthropogenic factors, such as environmental pressures, human migration, and socioeconomic practices, have shaped the genomic structure of goats, little is known regarding the resulting genetic adaptations. The goat (Capra hircus) have become well adapted to certain extreme environments (e.g., plateaus and deserts). Through whole-genome sequencing, it was hypothesized here that the immune system and olfactory perception genetic regulatory pathways may contribute to the defense related adaptations of the goat population. As such, CNGA4 and Camk 2b have been identified as key candidate genes that drive these adaptations during goat domestication, and they may enhance immunity and defenses against external adverse factors. This study provides a new insight into the unique regional defense adaptation of Qaidam cashmere goats during the generations long domestication process, in order to provide a theoretical basis for the adaptation of cashmere goats to a commercial environment.Results: More than 3,000 candidate genes have been found that may have been selected for through both natural and artificial processes during domestication. These candidate genes require validation with additional samples in the future. novel immune and olfactory perception genetic regulatory pathways were identified, which may correspond to defensive adaptations to the extreme environments.Conclusion: CNGA4 and Camk 2b may enhance immunity and defense against external adverse factors during domestication.
Avaliação microbiológica de cones de guta-percha: estudo in vitro
Authors: Guedes Mariana Ramos , Medeiros Péricles Natanael Fernandes de , Costa Mayanne Leite da , Morais Ingryd Sales , Freitas Jéssica Lucena , Aragão Gabriel Leite Rafael de , Cruz José Henrique de Araújo , Bezerra Priscila Medeiros , Silva Paula Vanessa da
Published: May 2021

A maior causa da necessidade de retratamento endodôntico é a resistência microbiana ao preparo químico-mecânico e aos materiais obturadores. Sendo importante avaliar o padrão de desinfecção dos cones de guta-percha utilizadas na obturação endodôntica, para que se obtenha a máxima desinfecção durante o tratamento. O objetivo do presente trabalho foi verificar a desinfecção dos cones de guta-percha utilizados na obturação endodôntica através de um estudo in vitro. Para tal, utilizou-se a seguinte metodologia: a amostra foi constituída por 45 cones de guta-percha, da 2° série (Dentsply®), dividida em duas coletas, uma inicial e outra final, a qual foi dividida em três grupos G1 (água destilada), G2 (hipoclorito de sódio) e G3 (clorexidina). Em cada grupo, foi utilizada uma substância de desinfecção, exceto no G1 (grupo controle). Inicialmente a análise foi realizada para verificar a esterilização dos cones em embalagens lacradas e posteriormente verificar a redução de microrganismos presentes nos cones de guta-percha, após o uso das soluções desinfectante. Os resultados dessa pesquisa evidenciaram que mesmo embalagens lacradas podem apresentar insucesso na esterilização dos cones, e que soluções de Hipoclorito de Sódio 2,5% e Clorexidina 2% foram eficazes em 75% dos casos, na desinfecção dos cones de guta-percha. Concluiu-se que, é necessária a desinfecção dos cones de guta-percha apesar de serem conduzidos em condições assépticas, e que ambas as soluções desinfectante foram eficazes na descontaminação prévia dos cones de guta-percha.
Lipoma em assoalho bucal: relato de caso
Authors: Barros Maylson Alves Nogueira , Teslenco Vitor Bruno , Reis Guilherme Nucci , Pancini Everton Floriano , Cavalcanti Herbert de Abreu
Published: May 2021

Introdução: Os lipomas são tumores mesenquimais benignos do tecido adiposo, composto por adipócitos maduro, envolvidos por um capsula fibrosa, sua fisiológica é completamente independente da gordura corporal geral, com crescimento autônomo e lento, o que lhe caracteriza como neoplasia benigna. Objetivo: Descrever relato de caso de um diagnóstico e tratamento de um lipoma em assoalho bucal. Relato de caso: Uma paciente com história de aumento de volume há cerca de 06 meses na região do assoalho bucal direito. O exame clinico apresentava-se como uma lesão com aspecto amarelo, próximo a superfície da mucosa, mole, séssil, bem encapsulada, assintomática, com hipótese de diagnóstico de lipoma. A paciente foi submetida tratamento cirúrgico através da exérese da lesão com anestesia local. Conclusão: O tratamento através da remoção simples da lesão com anestesia local proposto foi efetivo até atual momento, sem sinais clínicos de recidiva.
Enxerto ósseo autógeno de crista ilíaca para tratamento de defeito mandibular
Authors: Barros Maylson Alves Nogueira , Teslenco Vitor Bruno , Reis Guilherme Nucci , Pancini Everton Floriano , Cavalcanti Herbert de Abreu
Published: May 2021

Introdução: Os enxertos ósseos para estes defeitos maxilofaciais já são utilizados a muitos anos, diversos técnicas ou materiais tem sidos proposto como enxertos autógenos vascularizados ou não, aloenxertos, xenogenos, aloplasticos e fatores de crescimento. A técnica de enxerto óssea consiste no transplante de um substituto ósseo para tratamento do defeito. Os enxertos ósseos autógenos ou autologos são adquiridos do próprio individuo, conta com algumas características como fornecer células vivas imunocompatíveis com o recepetor Objetivo: Apresentar o tratamento de um defeito mandibular através do uso de enxerto autógeno associado a membras de plasma rico em fibrina. Relato de caso: Uma paciente com defeito mandibular devido quadro de osteomielite após trauma, foi submetida tratamento cirúrgico com reconstrução óssea através de enxerto ósseo autógeno da crista ilíaca. Conclusão: O enxerto ósseo de crista ilíaca, apesar de necessidade de leito doador, apresenta vantagem de ter disponível grande quantidade de tecido ósseo, até atual momento não foi documentado nenhuma complicação pós-cirúrgica.
Efeitos da música na comunicação do idoso: panorama das pesquisas brasileiras
Authors: Pinheiro Lígia Silva , Mansur Andreza Carla Maria da Silva , Fidêncio Vanessa Luisa Destro , Maximino Luciana Paula , Corrêa Camila de Castro
Published: May 2021

Introdução: A fonoterapia pode auxiliar na comunicação de quadros neurológicos, como Acidente Vascular Cerebral, Alzheimer, Parkinson, Esclerose Lateral Amiotrófica e Demências, podendo ser potencializada com a utilização de música associada. Objetivo: Investigar os efeitos da música na comunicação do idoso, baseado nos achados brasileiros. Métodos: A revisão bibliográfica foi estabelecida a partir de buscas realizadas nas bases de dados Google Acadêmico e Portal Regional Virtual Health Library, por meio dos cruzamentos dos seguintes descritores música, idoso e reabilitação. Resultados: As referências pesquisadas expressaram dentre os efeitos na comunicação, a melhora na sequencialização, verbalização, atenção, entonação, prosódia, e a estimulação neuronal, melhorando lateralização, sequência lógica, espaço temporal e memória. Verificou-se também a utilização de métodos como a terapia de entonação melódica, como instrumento de potencialização das habilidades comunicativas comportamentais e consideráveis ativações neuronais. Conclusão: Foi possível verificar que a música traz benefícios nas terapias fonoaudiológicas, em relação à reabilitação na comunicação, canto, fala, linguagem, melhora a prosódia, estimula a memória e a aprendizagem. Sugere-se que futuros estudos busquem padronizar protocolos para o acompanhamento a curto e longo prazo desses possíveis efeitos.
Ruído no lazer: uso de estéreos pessoais com fones de ouvido durante atividades físicas
Authors: Diedio Pollyana Nascimento , Amaral Mariane , De Conto Juliana
Published: May 2021

Introdução: Academias de ginástica utilizam músicas em intensidade elevada como forma de motivação para as atividades físicas, apesar disto muitos jovens optam por utilizar simultaneamente, fones de ouvido de seus estéreos pessoais. Objetivo: Investigar os efeitos auditivos e extra-auditivos causados pela música amplificada por estéreos pessoais com fones de ouvido durante atividades físicas. Metodologia: Participaram do estudo 31 adultos frequentadores de academias, usuários de estéreos pessoais. Foi aplicado questionário para investigação de efeitos auditivos e extra auditivos e realizada medição do nível de ruído ambiente da academia e dos estéreos pessoais de cada participante. Resultados: A maioria dos participantes utiliza fones de ouvido de uma a duas horas diárias nas academias, com maior frequência de cinco a seis dias por semana. Alguns participantes apresentam no cotidiano sintomas de redução da audição e plenitude auricular, bem como irritação e dor de cabeça. Os efeitos auditivos mais relatados após o uso de estéreos pessoais foram a plenitude auricular, redução da audição e zumbido, enquanto os efeitos extra auditivos mais relatados foram a dor de cabeça e a insônia. Observou-se que o NPS dos estéreos pessoais, usados simultaneamente ao som da academia, teve média de 95,4 dBNPS e quanto ao ruído ambiente das academias, a média foi de 78,1 dBNPS. Conclusão: As queixas auditivas e extra auditivas relatadas após o uso de fones de ouvido, continuaram sendo as mesmas do cotidiano, como plenitude auricular, dor de cabeça e insônia, mas com maior incidência.
Manifestação atípica da Doença de Paget em seio maxilar esquerdo: relato de caso
Authors: De Oliveira Vivian Bentes , Cabral Lioney Nobre , Pinheiro Tiago Novaes , Araújo de Vasconcelos II Antônio Jorge , Vieira Myrian Salles
Published: May 2021

Introdução: A doença de Paget (DP) ou osteíte deformante é uma doença osteometabólica benigna, caracterizada pela reabsorção e deposição anormal e anárquica de osso, este osso é menos resistente e mais suscetível a fraturas. Objetivo: mostrar caso clínico de manifestação atípica de DP que afetou área de seio maxilar (maior intensidade) e outras regiões como cóccix, tubérculo ilíaco direito e esquerdo e articulação sacroilíaca direita e esquerda, numa paciente do sexo feminino de 63 anos que queixava dor em hemi-maxila esquerda com aumento progressivo local desde a juventude. Esta acometia região dos dentes remanescentes ipsilaterais 23 e 24 com doença periodontal crônica grave. Material e método: Por exames de imagem observou hiperdensidade que preenchia quase toda a extensão do seio maxilar esquerdo com áreas de hipodensidade e na cintilografia apresentava maior captação de radiofármaco também nesta localização. Para elucidação diagnóstica, cujas hipóteses contemplavam, além de DP, também tumor marrom do hiperparatiroidismo e osteossarcoma, foram solicitados exames laboratoriais: TSH, creatinina, PTH, T3, T4, fosfatase alcalina, albumina, microalbumina, TGP, cálcio sérico, aldolase e calcitonina que não apresentaram nenhuma alteração, sendo indicada a biopsia incisional para análise histopatológica e conclusão diagnóstica. Resultado: Feita a interrelação das características clínicas, laboratoriais, imagenológicas e exame histopatológico, obteve-se diagnóstico de DP. Conclusão: Após diagnóstico, paciente foi encaminhada para tratamento reumatológico. O tratamento ordinariamente transcorre com o uso de bifosfonatos para redução da remodelação óssea, sendo amplamente usado o ácido zoledrônico além de analgésicos para o controle da dor.
Talon cusps - functional solution: a case report
Authors: Silva-Sousa Alice Corrêa , Silva-Sousa Yara Teresinha Corrêa , Tavella-Silva Nathalia Cristina , Danelon Marcelle
Published: May 2021

Talon cusp is a rare dental anomaly that occurs more frequently in maxillary incisors and is defined as a projection in the area of the cincture of anterior teeth that extends from the cemento-enamel junction or the region of the cincture, following towards the incisal face. An eight-year-old female patient was referred to the University of Ribeirão Preto Pediatric Dentistry Clinic (UNAERP) with suspicion of a supernumerary tooth on the palatal surface of tooth 12. During clinical and radiographic examination she found the presence of a conical-shaped enamel projection that presented a communication with the tooth 12 cincture and was thus classified as a talon cusp. Initially, prophylaxis and removal of the accumulated bacterial plaque were performed, verification of premature contact with paper for the joint and wear with a spherical diamond tip. FluroShield sealant was then applied following an adhesive protocol indicated by the manufacturer. After the necessary occlusal adjustments were made. 30 days later, the patient returned for clinical follow-up, reconversion and repolishing of the sealant. The talon cusp was diagnosed as Type I because it is morphologically well delineated and protrudes prominently from the palatal surface and extends at least halfway from the cemento-enamel junction to the incisal edge. It is recommended to seal the deep grooves to prevent caries. We can conclude that a rigorous clinical and radiographic examination leading to an early and accurate diagnosis is of extreme importance for the adoption of an adequate treatment.
Mucocele mimetizando neoplasia glândular em região do palato: relato de caso
Authors: Oliveira Rywendher dos Santos de , Pinheiro Tiago Novaes , Cabral Lioney Nobre
Published: May 2021

A mucocele é considerada uma lesão comum da mucosa oral, que resulta da ruptura de um ducto de glândula salivar e extravasamento de mucina para dentro dos tecidos moles adjacentes. Frequentemente encontrada no lábio inferior, o presente trabalho descreverá um caso de mucocele em mucosa do palato, considerada um região atípica, para muitos autores. Paciente do gênero feminina, 51 anos de idade, melanoderma, foi encaminhada para a Policlínica odontológica da UEA, com hipótese diagnóstica de hemangioma. Na anamnese, paciente relatou tempo de evolução de 5 meses, ausência de sintomatologia dolorosa, negou possuir hábitos de sucção e não ter traumatizado a área durante a alimentação ou escovação, além de não possuir hábito tabagista, etilista ou fazer uso de prótese, e sem histórico de doença sistêmica. Diante das informações clinicas, estabelecemos hipóteses diagnósticas: Carcinoma Mucoepidermóide e Mucocele. O diagnóstico foi confirmado através de biopsia excisional da lesão e exame histopatológico. Portanto, mesmo se tratando de uma lesão simples, podemos nos deparar com dificuldade diagnóstica, quando a localização da lesão é incomum. Entretanto, cabe ressaltar a importância de uma análise diferencial do caso, que para o presente trabalho, foi de grande importância para se chegar ao diagnóstico e assim proporciona um tratamento eficaz para a paciente.
E-COMMERCE NA HOTELARIA DE FORTALEZA-CEARÁ: IMPACTOS ECONÔMICOS E COMPETÊNCIAS PARA O EXERCÍCIO PROFISSIONAL
Authors: Castro Victor Hugo Santos de , Sousa Nathália Nadja Sales e
Published: May 2021

A internet é uma tecnologia que revolucionou o mundo, gerando oportunidades para o turismo e principalmente para o setor hoteleiro. Com o avanço da internet, surge o comércio eletrônico ou e-commerce, que consiste na atividade de vendas de bens e serviços através da internet. O objetivo geral desta pesquisa foi analisar os impactos do comércio eletrônico na venda dos produtos e serviços nos empreendimentos hoteleiros de Fortaleza-Ceará. Tratou-se de uma pesquisa de campo, do tipo exploratória, com abordagem quali-quantitativa, cujos dados foram coletados por meio de entrevistas semiestruturadas e questionários, analisados através de transcrição de falas e gráficos, respectivamente. Os participantes da pesquisa foram os gestores de dez meios de hospedagem e cinquenta acadêmicos do curso de hotelaria de uma instituição de ensino superior da localidade. Os resultados obtidos evidenciam que a hotelaria vem explorando o e-commerce como um diferencial competitivo para vender mais acomodações no mercado. Notou-se que as agências de viagem online são os canais mais utilizados atualmente. Numa outra perspectiva observou-se que os acadêmicos de hotelaria necessitam e desejam mais conhecimentos sobre a área, que é promissora.
EFEITOS DA SECA DE 2012 A 2016 NA QUALIDADE DA ÁGUA NOS AÇUDES ESTRATÉGICOS DA BACIA DO BANABUIÚ – CEARÁ
Authors: Abreu Martha Uchôa
Published: May 2021

O uso intenso dos recursos hídricos devido ao aumento nos padrões de consumo e crescimento populacional, compromete o equilíbrio e a manutenção da qualidade e quantidade da água. Nesse contexto, o Nordeste Brasileiro apresenta diversas dificuldades na gestão dos recursos hídricos por estar localizado em uma região de escassez hídrica, particularmente em períodos de seca como a ocorrida no período de 2012 a 2016 no Estado do Ceará, que afetam quali-quantitativamente as águas armazenadas em reservatórios superficiais. O presente trabalho teve como principal objetivo avaliar os efeitos da seca de 2012 a 2016 na qualidade da água de açudes estratégicos da bacia do Banabuiú, buscando analisar os dados de qualidade oriundos do monitoramento da Companhia de Gestão de Recursos Hídricos do Ceará – COGERH. A partir de correlações de variáveis qualitativas, como IET (Índice de Estado Trófico), Cianobactérias e Fósforo, com o volume de água acumulado, constatou-se que quando os açudes estão com maiores volumes armazenados eles tendem a apresentar menores valores do IET. Conclui-se ainda que com a correlação dos açudes com menos de 20% do volume acumulado e o estado trófico no período de 2008 a 2017, verificou-se que a seca de 2012 a 2016 trouxe implicações na qualidade da água, visto que após esse período, 60% a 80% dos açudes passaram a estar com menos de 20% do volume acumulado, e todos os açudes com dados disponíveis estavam em estados eutrofizados ou hipereutrofizados.
QUALIDADE PÓS-COLHEITA DE MELÃO “TORREON” PARA EXPORTAÇÃO
Authors: Marques Anselmo Francisca Deuzenir , SILVA EBENÉZER DE OLIVEIRA , FIGUEIREDO RAIMUNDO WILANE DE
Published: May 2021

Avaliou-se a vida útil pós-colheita de melões ‘Torreon’, sob refrigeração, tratados com SmartFreshTM (1-Metilciclopropeno, 1-MCP) após a colheita. Os frutos foram colhidos em estádio comercial (75% de rachadura do pedúnculo), numa fazenda localizada na região de Mossoró, no Rio Grande do Norte, sendo transportados via terrestre para o Laboratório de Fisiologia e Tecnologia Pós-colheita da Embrapa, Fortaleza-CE, distante cerca de 240 quilômetros. No laboratório, os frutos foram separados em três lotes e colocados em câmaras plásticas (0,186m3), vedadas com tampa de acrílico, para a aplicação de 1-MCP gasoso, nas dosagens de 0, 300 e 600 ηL.L-1 (ppb), por períodos de exposição de 6 e 12 horas. Após a aplicação do 1-MCP, os frutos foram acondicionados em caixas de papelão e armazenados por 21 ou 28 dias, na temperatura de 7±1ºC e umidade relativa de 80±2%. Após esses períodos de armazenamento refrigerado, os frutos foram transferidos para o ambiente (25±3ºC, 65±5%UR), extraiu-se a polpa até a região delimitante da parte comestível com a casca. Após homogeneização em processador doméstico, parte do suco foi armazenada em freezer para o doseamento de açúcares totais, açúcares redutores, pH, acidez total e sólidos solúveis totais. Observaram-se, de uma maneira geral, em ambos os experimentos (21 e 28 dias de armazenamento refrigerado), que os frutos controle apresentaram teor de SS superior ao dos frutos tratados com 1-MCP e esse fato foi dependente da dosagem utilizada. Não houve diferença significativa entre os períodos de armazenamento, ou seja, o melão ‘Torreon’, quando tratado com 1-MCP pode ser armazenado tanto por 21 como por 28 dias sem prejuízo da sua comercialização.
Evaluation of silibinin as an efflux pump inhibitor in Bacillus subtilis
Authors: ALTINIŞIK Fatma , ATAŞ Başak , AVCI Fatma Gizem
Published: May 2021

Antibiotic resistance has become a global health problem for humankind. Improper use of antibiotics resulted in the increasing evolved bacterial resistance to them. There are different types of bacterial resistance mechanisms including efflux pumps. To overcome the efflux pump activity on the drugs, combinatorial therapy of the existing antimicrobials with natural products is a promising insight to prevent increasing multidrug resistance. In this study, the inhibitory action of a plant-derived molecule silibinin on efflux pumps of Bacillus subtilis was investigated. The cellular effect of silibinin was investigated using minimum inhibitory concentration and growth studies. In addition, the efflux pump action of silibinin was monitored by ethidium bromide accumulation assay on the organism. According to results, silibinin has a MIC value between 100-200 µgmL-1 on microplate assay and 100 µgmL-1 of silibinin inhibited the cell growth. Ethidium bromide accumulation assays were performed at a safe silibinin range (25 and 50 µgmL-1) for eliminating the cell death, and ethidium bromide accumulation was increased with the increasing silibinin concentration. Ethidium bromide accumulation and growth results proved that silibinin has significant efflux pump inhibitor activity on Bacillus subtilis cells and silibinin is a promising inhibitor candidate to eliminate bacterial resistance mechanism.
Technical comment on the paper of Dessert et al. "The dark matter interpretation of the 3.5 keV line is inconsistent with blank-sky observations"
Authors: Boyarsky Alexey , Malyshev Denys , Ruchayskiy Oleg , Savchenko Denys
Published: May 2021

An unidentified line at energy around 3.5 keV was detected in the spectra of dark matter-dominated objects.
Recent work [1] used 30~Msec of XMM-Newton blank-sky observations to constrain the admissible line flux, challenging its dark matter decay origin.
We demonstrate that these bounds are overestimated by more than an order of magnitude due to improper background modeling.
Therefore, the dark matter interpretation of the 3.5~keV signal remains viable.
The Loschmidt Index
Authors: Liska Diego , Gritsev Vladimir
Published: May 2021

We study the nodes of the wavefunction overlap between ground states of a parameter-dependent Hamiltonian. These nodes are topological, and we can use them to analyze in a unifying way both equilibrium and dynamical quantum phase transitions in multi-band systems. We define the Loschmidt index as the number of nodes in this overlap and discuss the relationship between this index and the wrapping number of a closed auxiliary hypersurface. This relationship allows us to compute this index systematically, using an integral representation of the wrapping number. We comment on the relationship between the Loschmidt index and other well-established topological numbers. As an example, we classify the equilibrium and dynamical quantum phase transitions of the XY model by counting the nodes in the wavefunction overlaps.
Selection of mathematical model of on-board capacity energy storage as element of hybrid traction unit of motor car rolling stock
Authors: Mezitis Mareks , Panchenko Vladyslav , Yatsko Serhiy , Vashchenko Yaroslav , Sidorenko Anatoliy , Sansyzbajeva Zura
Published: May 2021

The authors of the study work out to determinate of the mathematical model of supercapacitors as an object of an electric traction system capable of providing non-encumbering of obtaining research results and correct reproduction of energy exchange processes in conditions of repeated-short-term modes of traction load operation. In paper, authors make a comparative assessment of six models for the possibility of their integration into the model of electric traction systems with on-board placement of the energy storage.
Degradation of micropollutant cephalexin by ultraviolet (UV) and assessment of residual antimicrobial activity of transformation products
Authors: Cordeiro Sabrina Grando , Ziem Rafaela , Schweizer Ytan Andreine , Costa Bruna , Kuhn Daniel , Haas Peterson , Weber Ani Caroline , Heidrich Daiane , Ethur Eduardo Miranda , Steffens Clarice , Hoehne Lucélia
Published: May 2021

Cephalexin (CEX) is an antibiotic commonly used to treat bacterial infections in humans and animals. However, it is also a micropollutant. Thus, this study evaluated the degradation of CEX using ultraviolet irradiation (UV-C) and analyzed the by-products as well as their residual antimicrobial activity. A reactor with a mercury vapor lamp was used for the degradation. Irradiated CEX solutions were collected over a period of 4 hours and analyzed using high-performance liquid chromatography coupled with mass spectrometry. For the residual antimicrobial activity the susceptibility test was performed using Staphylococcus aureus and Escherichia coli microorganisms by broth microdilution. It was found that CEX, after treatment, generated a metabolite with a mass of 150 m/z in 15 min. A four- and eightfold increase in the minimum inhibitory concentration of the drug against S. aureus and E. coli could be observed, respectively, after 20 min. Therefore, this treatment proved to be effective in the degradation of CEX, being able to degrade 81% of the initial molecule of the drug in 20 min. Furthermore, the antimicrobial activity of the CEX solution decreased as the irradiation time increased, indicating loss of antimicrobial function of the initial CEX molecule and the resulting by-products.
The Duration of Hemodialysis and its Implication to Barthel Score and Laboratory Parameters among End Stage Renal Disease Patients
Authors: Jahidi Savero Mizan , Mardiana Nunuk , Wardhani Indrayuni Lukitra
Published: May 2021

Background: While it was proven that hemodialysis for treating patients with end stage renal disease (ESRD) provided the reduced mortality rate, the reports on its adequacy in the context of laboratory parameters and psychological function were limited. Aim: To assess the implication of hemodialysis duration on Barthel score and laboratory parameters among ESRD patients. Â Methods: During the period, a cross-sectional study was conducted at Dr. Soetomo General Hospital. Information related to age, gender, history of hypertension, history of diabetes mellitus, and the levels of hemoglobin, albumin, calcium, and phosphor were retrieved from medical records. While, we performed the interview to each participant using Barthel index questionnaire to assess the function independence. We used multiple logistic regression analysis to determine the correlation and estimate of effect. Results: We totally include we included 65 patients with the hemodialysis duration of more than one year and 16 patients with the hemodialysis duration of less than one year. Our results found that the higher levels of albumin and hemoglobin were observed in patients with hemodialysis duration of more than one year. While, the duration of hemodialysis did not affect the Barthel score and serum mineral parameters. Conclusion: Â The duration of hemodialysis of more than one year is associated with the improvement of albumin and hemoglobin levels
EFFECTS OF FERMENTATION DURATION ON PHYSICOCHEMICAL AND ORGANOLEPTIC CHARACTERISTICS OF THREE AGARWOODS (Aquilaria) LEAVES TEA
Authors:   Brawijaya University, Leksono Anisa , Murtini Erni Sofia ,   Brawijaya University
Published: May 2021

Aquilaria is one of the plant genus-producing agarwood. Aquilaria leaves have pharmacological effects which the potential to be processed into black tea. The aim of this study is to determine the effect of fermentation duration on physicochemical and organoleptic characteristics of Aquilaria leaves tea. This study employed a Completely Randomized Design with two factors; the plant species (A. crassna, A. malaccensis, and A. subintegra) and fermentation duration (0 minutes, 70 minutes, and 90 minutes). Parameters analyzed including water content, total phenol, and antioxidant activity. Organoleptic tests were performed on the color, taste, and aroma of the brewed tea. The results summarized that A. subintegra had the highest total phenol and antioxidant activity, but the taste of the tea was not favored. A. crassna fermented 70 minutes and A. malaccensis fermented 0 minutes were the most preferred, but both have lower total phenol and antioxidant activity than A. subintegra.