bluuebunny/crossref_metadata_2025 huggingface dataset:
DO ENTRUDO AOS PASSEIOS
Authors: Ferreira FeliPe
Published: December 2022

No início do século XIX, o carnaval do Rio de Janeiro se organizava em torno de um entrudo popular, grosseiro e característico das ruas da cidade, e outro, mais delicado e familiar, que tinha lugar dentro das casas senhoriais. Com o intuito de “civilizar” esses festejos, considerados grosseiros e ligados ao passado colonial, a elite carioca importaria o carnaval parisiense, com seus bals masqués em teatros e salões. Para se chegar aos bailes, organizavam-se cortejos de carruagens. Estes acabavam por se deparar com as brincadeiras populares que não tinham desaparecido. O resultado desse encontro entre os diferentes grupos carnavalescos seria a hierarquização das vias urbanas. As modificações por que passaria a festa traduziriam, desse modo, não somente a tensão e a oposição entre as classes sociais, mas também sua abertura ao diálogo. O moderno carnaval brasileiro é, portanto, um casamento entre as tradições populares e o modelo estrangeiro, tomando posse do espaço público e se transformando na festa de toda uma cidade, de toda uma população.
LA FÊTE URBAINE DANS UNE MÉTROPOLE MÉDITERRANÉENNE
Authors: Marcilhac Vincent
Published: December 2022

Séville est un prototype de la métropole méditerranéenne, dans laquelle la sociabilité festive rassemble les habitants autour de la célébration de la cité. La fête marque profondément l’identité urbaine : la culture de la rue (bars à tapas, movidaetc.), la saison des festivités qui s’étale des processions religieuses de la Semaine Sainte à la célébration de la ruralité lors de la Féria d’Avril, et les événements exceptionnels qu’ont été les expositions de 1929 et 1992, montrent que la fête urbaine est non seulement ancrée dans le mode de vie sévillan, mais qu’elle est aussi un moyen de transformer l’urbanisme de la capitale andalouse.
CARNAVALS DE MARIAGE ET APPROPRIATION DE L’ESPACE PUBLIC URBAIN À YAOUNDÉ
Authors: FeudJio Yves Bertrand DJouda
Published: December 2022

La ville africaine ne saurait plus être analysée seulement comme « ville violente », sans avenir ; il y a lieu de l’observer aussi comme un véritable « laboratoire » des dynamiques urbaines où se construisent de nouveaux modes de vie, des dynamiques imprévues et annonciatrices de ruptures politiques, sociales et économiques. A Yaoundé ou à Douala, au Cameroun, il ne se passe pas de weekend sans que l’on n’observe des carnavals de mariage dans les rues principales. Ces carnavals, qui regroupent très souvent des centaines de personnes ou des dizaines de voitures, attirent au passage tous les regards, arrachent à la fois des applaudissements, des cris d’admirations et des brocards. Ils occupent sans autorisation administrative la voirie urbaine, imposent aux autres citoyens une circulation difficile, bref, ils marquent une véritable appropriation de l’espace public urbain. Ce phénomène émergent dans les villes camerounaises suscite des interrogations à la fois sur ses logiques et surtout sur ses enjeux pour les acteurs sociaux.
PEMBERIAN KOMPRES DINGIN UNTUK MENGURANGI NYERI PERSALINAN
Authors: Pratama Renda Natalina
Published: December 2022

Latar Belakang: Peristiwa fisiologis pada saat persalinan terkadang dapat menimbulkan trauma pada ibu karena nyeri yang dialaminya. Metode nonfarmakologi merupakan suatu pendekatan yang digunakan untuk menghilangkan nyeri tanpa obat-obatan. Terapi kompres dingin merupakan salah satu metode nonfarmakologi untuk mengatasi nyeri. Metode ini mempunyai resiko yang sangat rendah, bersifat murah, simple, efektif tanpa efek yang merugikan dan dapat meningkatkan kepuasan selama persalinan.  Tujuan: Penelitian ini bertujuan menilai efektifitas penerapan kompres dingin untuk mengurangi nyeri persalinan. Metode: Desain dalam penelitian ini adalah analisis deskriptif dengan pendekatan studi kasus (case study). Subjek dalam penelitian ini adalah Ny “D” berusia 26 tahun yang diberikan asuhan mulai trimester 3 kehamilan hingga masa nifas. Tempat pelaksanaan di PMB Murtiyah Belitang yang dilaksanakan pada bulan Desember 2020 sampai Maret 2021. Studi kasus dalam penelitian ini adalah dengan memberikan asuhan komprehensif sejak masa hamil hingga masa nifas. Studi kasus ini juga menilai efektifitas pemberian kompres dingin untuk mengurangi nyeri pada pada kala I persalinan. Analisis data pada penelitian ini menggunakan one grup pretest posttest design yaitu dengan membandingkan nilai rata-rata skala nyeri (NRS) sebelum diberikan perlakukan kompres dingin dan setelah diberikan perlakuan kompres dingin pada Ny “D”. Hasil: Asuhan kebidanan komprehensif berjalan dengan lancar dan baik. Setelah dilakukan kompres dingin pada persalinan kala I fase aktif setiap 30 menit sekali dan dalam waktu 10 menit dengan suhu es 10-15ºC, terdapat penurunan rata-rata nyeri yang diukur dengan skala NRS. Pemberian terapi kompres dingin pada Ny “D” bermanfaat mengurangi rasa nyeri pada kala I persalinan. Kompres dingin dapat disarankan untuk diaplikasikan oleh tenaga kesehatan  dalam mengurangi nyeri persalinan. Kata Kunci: Persalinan, Nyeri, Kompres Dingin
HUBUNGAN USIA DAN PENGETAHUAN SISWA TERHADAP DETEKSI DINI KANKER PAYUDARA
Authors: Astuti Desti Widya
Published: December 2022

Latar Belakang: Penyakit kanker merupakan salah satu masalah kesehatan di seluruh dunia. Meningkatnya angka kematian akibat kanker payudara salah satunya karena terdeteksi pada stadium lanjut. Keterlambatan deteksi dini kanker payudara dikarenakan kurangnya pengetahuan tentang pemeriksaan payudara sendiri. Pemeriksaan ini direkomendasikan sejak wanita berusia 20 tahun dengan dilakukan sendiri di rumah setiap bulannya.Tujuan: Untuk mengetahui hubungan usia dan pengetahuan siswa terhadap deteksi dini kanker payudara di Sekolah Menengah Kejuruan Kesehatan Pelita Insani Kota Prabumulih tahun 2021. Metode: Penelitian ini menggunakan survey analitik dengan pendekatan cross sectional. Populasi yang diambil pada penelitian ini adalah siswa perempuan Sekolah Menengah Kejuruan Kesehatan Pelita Insani Kota Prabumulih kelas XI Keperawatan A dan B tahun 2021 sebanyak 60 orang, dengan jumlah sampel sebanyak 40 orang dengan menggunakan teknik accidental sampling. Pengambilan data dilakukan pada bulan Juli 2021. Hasil: Hasil uji statistik diperoleh usia siswa mempunyai hubungan yang bermakna dengan deteksi dini kanker payudara (p value 0,002) dan pengetahuan siswa mempunyai hubungan yang bermakna dengan deteksi dini kanker payudara (p value 0,001). Saran: Diharapkan kepada tenaga kesehatan agar rutin melakukan kegiatan skrining pada remaja agar dapat melakukan deteksi dini kanker payudara dengan cara SADARI.                                                                                             Kata Kunci: Usia, Pengetahuan, Deteksi Dini, Kanker Payudara
LITERATUR REVIEW: KUALITAS PELAYANAN TERHADAP KEPUASAN PASIEN PESERTA BPJS
Authors: Dewi Lisneni
Published: December 2022

Latar belakang: Kualitas pelayanan mempunyai peran yang sangat penting terhadap kepuasan pelanggan. Pelanggan akan merasa puas apabila mereka mendapatkan pelayanan dengan kualitas terbaik. Kualitas pelayanan yang baik akan mampu menciptakan kepuasan bagi konsumennya. Dalam pelayanan BPJS Kesehatan tingkat kepuasan peserta BPJS merupakan hal yang penting. Sebagai Perusahaan yang bergerak dalam bidang jasa kepuasan pelayanan perlu diperhitungkan untuk meningkatkan mutu pelayanan dan kepuasan bagi peserta BPJS kesehatan. Tujuan: Untuk mengetahui pengaruh kualitas pelayanan Kesehatan terhadap kepuasan pasien peserta BPJS. Metode: Penelitian ini menggunakan metode Literature Review dengan mengambil sumber data dari database elektronik yaitu Google Scholar. Artikel yang diterbitkan dari tahun 2016-2020. Setelah dilakukan seleksi dan diidentfikasi sesuai dengan kriteria inklusi, terdapat 10 artikel yang akan di review. Hasil: ada 7 Artikel yang berpengaruh signifikan antara kepuasan pasien terhadap kualitas pelayanan kesehatan BPJS dan 3 Artikel yang tidak ada pengaruh kenyamanan terhadap Responsivitas (daya tanggap) dan empati, variabel tangible (tampilan fisik) dan trust terhadap kepuasan pasien. Saran: Bahwa untuk meningkatkan kepuasan pasien BPJS adalah dengan menciptakan dan mengelola suatu system untuk memperoleh pasien yang lebih banyak dan kemampuan untuk mempertahankan pasiennya. Kata Kunci: Kualitas Pelayanan, Kepuasan Peserta, BPJS Kesehatan
HUBUNGAN LAMA PENYEMBUHAN LUKA DAN TINDAKAN PERAWATAN DENGAN PERAWATAN PENYEMBUHAN LUKA PADA IBU SECTIO CAESAREA
Authors: Sumantri Apria Wilinda , Fitri Yulita Eka
Published: December 2022

Latar Belakang: Persalinan merupakan kejadian fisiologi yang normal yang dialami oleh seorang ibu berupa pengeluaran hasil konsepsi. Apabila persalinan normal tidak memungkinkan dilakukan, maka diperlukan satu cara alternatif lain dengan mengeluarkan hasil konsepsi melalui pembuatan sayatan pada dinding uterus melalui dinding perut yang disebut sectio caesarea. Hal ini dilakukan jika persalinan normal tidak mungkin dilakukan karena akan mengancam nyawa ibu dan bayi. Luka setelah dilakukan pembedahan sectio secarea akan mengalami penyembuhan luka. Tujuan: Diketahui hubungan antara lamanya Penyembuhan luka dan Tindakan Perawatan dengan Perawatan Penyembuhan Luka pada Ibu Sectio Caesaria di RSUD Dr. Ibnu Soetowo Baturaja Kabupaten Ogan Komering Ulu Tahun 2022. Metode: Penelitian ini menggunakan metode survey analitik dengan pendekatan cross sectional. Penelitian ini dilakukan di RSUD Dr. Ibnu Soetowo Baturaja pada bulan Maret 2022, yang menjadi populasi dalam seluruh ibu post partum yang ada di ruang obgyne dan yang tercatat di rekam medik berjumlah 105 orang dengan jumlah sampel 35 responden. Hasil data dianalisa dengan menggunakan uji chi square dengan alpha 0,05. Hasil: Uji statistik yang dilakukan pada ibu post sc didapatkan sebanyak 18 responden (51,4%) yang lama penyembuhan lukanya selama > 5 hari, 23 responden (65,7%) yang tidak melakukan tindakan perawatan luka dan perawatan penyembuhan luka yang tidak steril sebanyak 20 responden (57,1%). Hasil analisis chi-square didapatkan ada hubungan yang bermakna antara lama penyembuhan luka (p value 0,002<0,05) dan tindakan perawatan (p value 0,005 <0,05) dengan perawatan penyembuhan luka. Saran: Bagi peneliti dalam melakukan penelitian juga memperhatikan faktor lain yang dapat mempengaruhi dalam penyembuhan luka yaitu kesterilan alat alat yang digunakan serta bagi peneliti selanjutnya hendaknya menggunakan referensi yang terbaru.Kata Kunci: Lama Penyembuhan, Tindakan, Perawatan Penyembuhan
C-REACTIVE PROTEIN AS A MARKER OF CLINICAL AND LABORATORY REMISSION IN PATIENTS WITH ACUTE NECROTIZING PANCREATITIS
Authors: Dronov Olexii I. , Kovalska Inna O. , Horlach Andrii I. , Shchyhel Ivanna A. , Prytkov Fedir O.
Published: December 2022

The aim: To estimate the role of C-reactive protein levels as a marker of clinical and laboratory remission in patients with acute necrotizing pancreatitis.
Materials and methods: A single-center retrospective non-randomized study of 68 patients (37 (54%) men, 31 (46%) women) was carried out in the period from September 2019 to October 2020. The patients were divided into two groups: group 1 included 9 (13.2%) patients rehospitalized within a month of observation after being discharged from hospital with improvement, group 2 consisted of 59 (86.8%) patients not readmitted within the observation period. A standard package of Microsoft Excel, program MedStat v.5.2, W-test Wilcoxon and the Fisher transform was used to record, calculate and compare data.
Results: Patients in groups 1 and 2 did not statistically differ in age (p = 0.727), gender (p = 0.202), body mass index (BMI) (p = 0.447), length of hospital stay (p = 0.913), volume of pancreatic lesion according to СTSI (p = 0.313) and severity of disease (p = 0.205). Incidence of pancreatic necrosis infection was 88.8% (p = 0.007) in group 1 versus 35.6% in group 2. In the group of rehospitalized patients, the level of C-reactive protein upon discharge was significantly higher (Me ± m 80.8± 9.734 (66) -88), CI 95%) compared with the patients from the group without readmission (Me ± m 21.36± 2.285 (16.1-31.1) CI 95%) p <0.001. As the “critical” CRP level for group 1, indicating readmission for infectious complications of AP, was chosen the value of the left limit of 95% CI (confidence interval), which made up ≥64.5 mg / ml.
Conclusions: According to the results of our study, the risk of readmission in patients with CRP level ≥64.5 mg / L prior to being discharged exceeded 41 times the risk of readmission in those with lower CRP values (RR 41.5 ± 1.008 (95% CI 5.75-299, p = 0.04)). For each patient with CRP levels≥64.5 mg / L, the risk of readmission within the first month after being discharged was 71% (95% CI 40.7-88.6, p
RECIPROCAL CLICKING LOCATION ANALYSIS IN THE INTRAARTICULAR TEMPOROMANDIBULAR DISORDERS AFTER AXIOGRAPHY INVESTIGATION
Authors: Zhehulovych Zinaida Y. , Kovalchuk Oleksandr I. , Etnis Leonid O. , Guryanov Vitaly G. , Sayapina Lada M. , Babaskin Yurii I.
Published: December 2022

+The aim: To investigate the peculiarities of hinge axis trajectories in patients with condyle-disc complex intraarticular Temporomandibular Disorders (TMD) and determine the average coordinates of the reciprocal clicking location by axiography.
Materials and methods: The results of axiographic examination of 151 patients (108 females and 43 males) with TMD confirmed by MRI were analyzed. This population included 44 persons with disc displacement with reduction (DDR), 45 persons with disc displacement with reduction and intermittent locking (DDRI), 62 persons with disc displacement without reduction (DDWR). Axiographic examination was carried out using CADIAX diagnostic device. Analysis of hinge axis movements was performed and the coordinates of articular disc reduction were determined.
Results: The quality of hinge axis trajectories in persons with DDR, DDRI was defined mainly as average and in patients with DDWR as poor. Quantitative indicators of trajectories during protrusion-retrusion movements were not beyond the average level. The length of the mouth opening-closing trajectory in patients with DDRI and DDWR has shown a tendency to decrease. We found that on average the reciprocal closing clicking (disc reduction) occurs at a distance of 0-1.4 mm on the X-axis, 0.1-2.9 mm on the Z-axis, and 0-0.85 mm on the Y-axis.
Conclusions: The obtained wide range of reciprocal clicking location parameters indicates the priority of a personalized approach when planning preliminary treatment in order to restore the disc-condylar complex of TMJ.
ANALYSES OF STRUCTURE AND INCIDENCE OF EXTRAGENITAL PATHOLOGY OF PREGNANT (2011 TO 2020 YEARS)
Authors: Lemish Nataliya Y. , Mitsoda Roman M.
Published: December 2022

The aim: To conduct analyses of structure and incidence of extragenital pathology, course of pregnancy and labour in pregnant from 2011 to 2020 years.
Materials and methods: Clinical and statistical analysis of 159,367 births over 2011-2020 years in Transcarpathian region was conducted. All complications of pregnancy were divided into 6 subgroups depending on the available obstetric pathology and extragenital pathology.
Results: The incidence of extragenital pathology among women born in the Transcarpathian region over the past 10 years has increased by an average of 6-10%. The incidence of placental dysfunction on the background of somatic morbidity in the maternity hospital in Uzhgorod increased during the study period from 6.1% (2011) to 10.9% (2020). A significant reduction in the number of births from 18,168,000 in 2011 to 13,150,000 in 2020 was noted. The incidence of combined somatic pathology increased from 10.4% in 2011 to 23.8% in 2020. (p <0.001).
Conclusions: It is necessary to develop comprehensive modern measures to prevent obstetric and perinatal complications in this group of pregnant women.
CORRECTION OF AUTONOMIC DYSFUNCTION IN OVERWEIGHT CHILDREN BY NORMALIZING BODY COMPOSITION
Authors: Palamarchuk Olga S. , Petrik Ksenija Yu. , Nemesh Marianna I. , Krichfalushii Oksana P. , Rishko Oleksandr A. , Feketa Volodymyr P.
Published: December 2022

The aim: To investigated the effect of a 3-month body weight correction program on the functional state of the ANS in children of primary school age who had an increased body mass index and signs of autonomic dysfunction.
Materials and methods: 82 children aged 9 to 11 were examined. During 3 months, all examinees underwent a body weight correction course. Body composition was mea¬sured by the bioimpedance method using the body composition analyzer «TANITA-BC-601» (Japan). The functional state of autonomic regulation was assessed using heart rate variability (HRV) indicators obtained by recording standard 5-minute ECG intervals using the computer hardware and software complex “CARDIOLAB” (XAI-MEDICA, Ukraine).
Results: Statistical processing of HRV indicators showed that 51 children (62.2%) had signs of autonomic dysfunction. In the first group, there was a statistically significant decrease in body weight (from 47.33±4.62 to 44.12±3.96), BMI (from 28.15±2.64 to 26.63±2.87), TFC (from 33.54±3.68 to 30.89±2.81), VF (from 7.056±1.814 to 4.817±2.017) with a simultaneous statistically probable increase in the FFM index (from 60.27±2.47 to 63.15±2,38). According to the time domain indicators of HRV, children in first group have increased the TP of autonomous heart rhythm regulation, as indicated by a statistically significant increase in SDNN from 38.43±6.39 ms to 51.65±7.19 ms (р<0.05); the activity of the sympathetic link of the ANS decreased according to AMo from 41.23±6.17% to 34.29±5.83% (р<0.05) and the intensity of autonomic regulation according to IS, which decreased from 116.3±31,6 units to 81.2±29.1 units (p<0.05).
Conclusions: 3-month body weight correction program led to the elimination of signs of autonomic dysfunction in 43.9% of the examined persons.
MORPHOLOGICAL RESEARCH OF ADHESIONS IN PATIENTS WITH TUBOPERITONEAL INFERTILITY
Authors: Romanenko Tamara G. , Shahanov Pavlo F.
Published: December 2022

The aim: To study history, clinical manifestations and histological structure of adhesions in patients with tuboperitoneal infertility.
Materials and methods: 66 women with tuboperitoneal infertility and 30 healthy women were studied. The criterion for inclusion in the study was the presence of adhesions of the 2nd and 3rd degrees by J. Hulka et al. classification. During laparoscopy adhesions were sampled. Serial histological sections after preparation were stained with hematoxylin and eosin, picrofuxin according to van Gizon and fuxelin according to Hart.
Results: The study showed that patients with tuboperitoneal infertility, unlike the control group, had surgery on the abdominal cavity and pelvic organs much more often, as well as inflammatory diseases of the reproductive organs. The majority of women in the control group had childbirth in history, whereas among the patients with infertility ectopic pregnancies and abortions prevailed. All examined women had adhesions that were confirmed during laparoscopy. The study showed that ultrasound is not an informative method to confirm this pathology. A histological study of adhesions revealed the presence of differences in their structure depending on the etiological factor (surgery or inflammation).
Conclusions: Necessary to take into account the presence or absence of a chronic inflammatory process while developing approaches for the secondary prevention of the formation of adhesions in women with tuboperitoneal infertility at the stage of postoperative rehabilitation and infertility treatment.
SAFETY OF USING DURAL PUNCTURE EPIDURAL ANALGESIA AS A METHOD OF LABOR ANALGESIA
Authors: Sulimenko Yevhen M. , Loskutov Oleg A. , Zhezher Andriy O.
Published: December 2022

The aim: To evaluate the clinical characteristics of complications and side effects of CSE and DPE as a method of analgesia.
Materials and methods: The study included 137 patients who had a vaginal birth using one of two, CSE or DPE methods of analgesia. All of them were divided into two groups: Group I – 54 women (DPE group) and Group II – 83 women (CSE group). In group I, an epidural kit with a Tuohy G18 needle, G20 catheter, and a Whitacre G25 x 120 mm spinal needle was passed through the epidural needle for puncture of dura mater and removed after cerebrospinal fluid receiving, the epidural catheter was conducted on 3-4 cm. The initial dose of anesthetic was: 3 ml of Naropin 0.12% – test dose and 17 ml of working solution (Naropin 0.12% + Fentanyl 2 μg / ml) – main dose. In group II, a spinal-epidural kit with Tuohy G18 needle, catheter G20, spinal needle “Whitacre” G27 x 132 mm for dura mater puncture was used. Bupivacaine 1.5 mg + Fentanyl 15 mcg, 1 ml solution was administered spinally. To maintain analgesia in both groups – the patient-controlled analgesia with a working solution (Naropin 0.12% + Fentanyl 2 μg / ml) with a bolus of 8 – 10 ml, lockout 15 minutes.
Results: The higher frequency of hypotension in childbirth when using CSE – 4 women (4.8%) vs 1 woman (1.9%) in the DPE group. Inadequate or insufficient analgesia in group I was found in 2 women (3.7%), and in group II in 4 women (4.8%). The severity of monolateral block in group I was not high and did not cause significant discomfort in women. The higher incidence of monolateral blockade was in group II, in three cases there was a need for additional anesthesiologist interventions and catheter manipulations. In the CSE group there were two cases (2.4%) of severe itching in women, in group I such an adverse reaction was absent. No complication such as PDPH was documented in either group.
Conclusions: 1. The use of the DPE technique showed a lower frequency of complications compared to CSE. 2. The use of a G 25 spinal needle for puncture of the dura mater does not lead to an increase in the frequency of PDPH. 3. DPE technique using G25 spinal needles reduces the need for additional manipulations with the epidural catheter to overcome unilateral blockades.
THE ROLE OF ENTEROVIRUSES IN THE DEVELOPMENT OF ISCHEMIC STROKE AND ITS OUTCOMES
Authors: Turchyna Nataliia S. , Cherenko Tatiana M. , Andriushkova Natalia G. , Melnyk Valentyna V. , Kuzminska Olena V. , Heletiuk Yuliya L.
Published: December 2022

The aim: To study the role of enteroviruses (EV) in the development of ischemic stroke and its outcome.
Materials and methods: The main group (MG) included 72 patients with acute cerebrovascular disorders were examined using the National Institutes of Health Stroke Scale and Barthel Index. The comparison group (CG) included 35 patients without cerebrovascular disease. Viruses were isolated from patients’ sera and identified in neutralization test. EV genomes were detected in polymerase chain reaction (PCR). Serological diagnosis was performed by enzyme-linked immunosorbent assay.
Results: EV genomes were more frequently detected in the patients’ sera in MG than in CG (23.6 ± 5.9% and 2.9 ± 2.8%, p <0.05). The greater level of neurological deficits was in patients with positive PCR test results comparatively with patients with negative PCR test results (11.76 ± 0.31 and 10.97 ± 0, 27, p = 0.040). The regression of neurological deficit during the treatment was a worse in patients with positive PCR test results and presence of specific IgG compared with patients with positive PCR test results and absence of specific IgG (11.2 ± 2.6% and 19.6 ± 2.4%, p = 0.031).
Conclusions: The trigger role of EV in the development of IS is established. PCR is recommended for diagnosis of EV in patients with IS.
PECULIARITIES OF OBESITY EFFECTS ON THE QUALITY OF LIFE AND PSYCHOEMOTIONAL STATE OF PATIENTS WITH BRONCHIAL ASTHMA
Authors: Нalamba Andriana A. , Kohutych Anton I. , Koval Galina M. , Vysochanska Vlasta V. , Dankanych Evhenia E.
Published: December 2022

The aim: To study the effect of concomitant obesity in patients with bronchial asthma on quality of life and psychoemotional state depending on the phase of the disease.
Materials and methods: 176 patients with bronchial asthma in different phases of the disease with normal weight, pre-obesity and obesity were examined. The quality of life and psycho-emotional state of the patients was determined by the «Sent George Respiratory Question» and the Spielberger-Hanin and Beck tests
Results: All studied patients, showed significant violations of the psychoemotional sphere, a decrease in quality of life compared to healthy individuals (p<0.05). The remission phase revealed a deterioration in the quality of life of patients with overweight and obesity compared to patients with normal weight (p<0.05), in the exacerbation phase – with obesity and normal body weight (p < 0.05). Exacerbation negatively affected the psycho-emotional sphere in patients with normal body weight and obesity (p<0.05).
Conclusions: The quality of life was reduced in all studied patients, regardless of body mass index(p<0.05), and the exacerbation of the disease worsened it (p < 0.05), increased depressive tendencies in patients with normal body weight and obesity (p<0.05). In patients with obesity, the worst quality of life indicators were found in the remission phase (p<0.05) and more pronounced depressive tendencies in the exacerbation phase than in the pre-obesity group (p<0.05). The most important indicators determining the course of bronchial asthma are quality of life and body mass index.
ANTIPSEUDOMONAL ACTIVITY OF METABOLIC COMPLEXES OF L. RHAMNOSUS GG AND S. BOULARDII AGAINST THE POLYRESISTENT PATHOGEN IN IN VITRO AND IN VIVO TESTS
Authors: Isayenko Olena , Minukhin Valerii , Minukhin Dmitriy , Yevtushenko Denys , Hroma Vasiliy
Published: December 2022

The aim: Explore the antimicrobial properties of lactobacilli’s metabolites and combination of lactobacilli’s and saccharomycetes’ metabolites with different concentrations (in vitro) and to test the effectiveness of samples with minimum inhibitory concentration on infected polyresistant strain P. aeruginosa skin wounds (in vivo) for the possibility of creating prophylactic antimicrobial agents.
Materials and methods: Metabolic complexes (L. rhamnosus GG and S. boulardi) were obtained by culturing lactobacilli or lactobacilli and saccharomycetes in lactobacilli disintegrates. The sensitivity of Pseudomonas aeruginosa PR (in vitro) to them was determined by the microtechnique of serial dilutions in a liquid nutrient medium. In vivo, 0.9 % sodium chloride solution (control) or lactobacillus metabolic complex (experiment, treatment group) was applied to infected skin wounds or, in addition, immediately before the infection, to the wound and then to infected wounds (experiment, prophylactic-treatment group).
Results: There was observed the decrease of the infectious process of skin wounds in the prophylactic-treatment group (3.25-3.4 times; p=0.01 related to control samples) compared with the treatment group (2.05-2.25 times; p=0.02) by the wound healing rate (day 5). The healing rate of control wounds (day 11) coincided with the rates of experimental wounds in the prophylactic-treatment group (day 8), indicating that the use of lactobacilli metabolites promotes the acceleration of healing by almost three days.
Conclusions: Metabolic complexes of probiotic microorganisms are promising for construction on their new class of antimicrobials for the effective pharmacoprophylaxis and pharmacotherapy.
EXPERIENCE OF THE TREATMENT OF PATIENTS WITH ACUTE PANCREATITIS
Authors: Filip Stepan S. , Slyvka Rudolf M. , Skrypinets Yuriy P. , Bratasyuk Andriy M. , Shitev Anatoliy I.
Published: December 2022

The aim: To improve the results of treatment of patients diagnosed with acute pancreatitis.
Materials and methods: The materials of the work are based on the clinical examination and treatment of 301 patients with acute pancreatitis, in the treatment of which, along with classical treatment, a therapeutic and diagnostic complex was used, which allows predicting and preventing the development of abdominal compartment syndrome (ACS).
Results: Managed to reduce the number of cases of infected pancreatic necrosis, effectively predict and prevent the development of abdominal compartment syndrome (ACS), reduce the average length of stay of patients in the hospital.
Conclusions: The use of the proposed management algorithm for patients with acute pancreatitis allows to shorten the treatment period by effectively predicting and preventing the development of pancreatic necrosis, its septic complications and abdominal compartment syndrome.
MORPHOFUNCTIONAL PECULIARITIES OF THE PLACENTA IN WOMEN WITH UNDIFFERENTIATED CONNECTIVE TISSUE DYSPLASIA SYNDROME
Authors: Maliar Volodymyr , Ibadova Tunzala , Maliar Vitalii , Maliar Vasyl
Published: December 2022

The aim: The impact of undifferentiated connective tissue dysplasia on the formation of the placenta.
Materials and methods: The morphostructure of 50 placentas with the undifferentiated connective tissue syndrome and 50 placentas of women with physiological pregnancy and absence of connective tissue pathology was studied.
Results: The results of morphological studies have shown that the main pathogenetic link of placental dysfunction with highly resistant blood flow in the umbilical arteries in pregnant women with undifferentiated connective tissue dysplasia syndrome is a disorder of functional differentiation of the villous tree.In these cases the dominats were large and medium-sized villi with narrowed lumen in arterial, venular and capillary vessels and arterial spasm and venous plethora, as well as with numerous chaotically sclerosed villi, indicating stage I and II of placental. There is a large amount of fibrins in intervillous space which narrows it and leads to violation of microcirculation and placenta tissue hypoxia.
Conclusions: The morphological basis of high flow resistance in the umbilical artery with the undifferentiated connective tissue dysplasia syndrome in pregnant women is a pathological immaturity of the placental villous tree. Morphological study of the architecture of the stem and intermediate placental villi revealed a violation of the structure of collagen fibers in the form of lack of crosslinks of bundles of collagen fibers.
MARKER DIAGNOSTIC HEART FAILURE PROGRESSION IN THE POST-INFARCTION PERIOD
Authors: Levandovska Khrystyna V. , Vakaliuk Ihor P. , Naluzhna Tetiana V.
Published: December 2022

The aim: To study the relationship between the concentration of copeptin, NT-proBNP, ST2 and indicators of myocardial remodeling, the dynamics of these indicators in order to predict the occurrence of decompensated heart failure (HF) in patients with acute myocardial infarction (AMI).
Materials and methods: The study is based on the results of the examination of 160 patients with MI, including 120 patients with decompensated CHF II A-B stage according to Vasylenko-Strazhesko classification of (FC) III-IV (according to NYHA) and 40 patients with MI without signs of decompensated CHF, as well as 20 medically healthy individuals. The level of copeptin, NT-proBNP, ST2 were determined.
Results: In patients with signs of decompensated HF there were significantly higher levels of NT-proBNP in the blood serum that amounted to (950.38±3.15) pg/ml, in patients without decompensated HF after MI (580.15±3.03) pg/ml compared to healthy individuals (111.20±3.47) pg/ml (p<0.05). The mean value of copeptin concentration in patients with decompensated CHF was recorded (18.11±0.12) pg/ml, compared to (12.03±0.14) pg/ml in patients with MI without signs of CHF decompensation.
Conclusions: The most significant for clinical and prognostic assessment of the post-infarction period complicated by decompensated HF is the response of the patient’s body to dosed physical exertion and the levels of NT-prpBNP, copeptin and ST2.
REPRODUCTIVE RIGHTS AND IMPLEMENTATION OF THE RIGHT TO HUMAN LIFE
Authors: Checherskiy Viktor I. , Badyda Andrianna Yu. , Roshkanyuk Vadym M. , Herych Anatolii Yo.
Published: December 2022

The aim: To find out the peculiarities of citizens’ implementation of their reproductive rights, while combining the basic principles of medicine and law.
Materials and methods: Formal-logical methods of analysis and synthesis allowed to reveal the content of the concepts that make up the subject of research, to classify them, as well as to formulate intermediate and general conclusions. The systematic method allowed to study the role and significance of human reproductive right among other somatic human rights and freedoms. Using the historical method, the doctrinal basis of the study was analyzed, and the main stages of the formation of human right to transplantation were identified. The application of the above-mentioned methods necessitates the inclusion of an activity method in the research methodology. This method, becoming a logical continuation of the integral structural-functional method, involves the study of relevant reproductive rights through the development of medical technologies.
Conclusions: The modern development of biotechnology has caused a number of serious threats to the possibility of realizing the human right to life. The modern understanding of the content of the right to life concerns a number of bioethical aspects, primarily related to the development of scientific and technological progress in both biology and medicine. The content of the human right to life in the context of the achievements of reproductive rights is significantly expanding, which leads to a new concept of it, not only as a fundamental human right, but also as a set of rights that relate to human life, taking into account the principles of bioethics. Therefore, the need to compare the goal and the means in biological and medical manipulations with human life, their consideration of the ethical and moral aspect is extremely important for the further development of the entire legal array regarding biomedicine.
LIVER CIRRHOSIS WITH CRYPTOGENIC GENESES. CLINICAL CASE
Authors: Horlenko Olesya M. , Kossey Gabriella B. , Pushkarenko Olha A. , Prylypko Lyubomyra B.
Published: December 2022

The article presents clinical observation of a patient with cryptogenic cirrhosis of the liver, a chronic diffuse progressive liver disease, which is manifested by structural rearrange¬ment of its parenchyma. Cryptogenic cirrhosis is cirrhosis of uncertain etiology that lacks definitive clinical and histological criteria for a specific disease. Cryptogenic cirrhosis accounts for nearly 5% to 30% of cases of cirrhosis and nearly 10% of liver transplants. The problem of cirrhosis of the liver is extremely relevant, because this pathology is observed mainly in young and able-bodied people. In addition, it takes the first place among the causes of mortality from diseases of the digestive system.
To clarify the diagnosis, laboratory and instrumental diagnostic methods of investigation were performed. Due to severe thrombocytopenia and minor leukopenia, myelodysplastic syndrome was suspected. Metabolic disorders that can be considered as probable in the occurrence of the above-mentioned changes in the liver parenchyma had been ruled out.
PRIVÉ : ENJEUX DU TÉLÉTRAVAIL EN AFRIQUE SUBSAHARIEN : QUELS ACQUIS POST-COVID-19 ?
Authors: Kadji Martial
Published: December 2022

Vu que le processus de déploiement du télétravail dû au Covid-19 soit en cours dans les PME Africaines, nous avons tiré des éléments contextuels permettant d’assurer la mise en place de cette forme de travail. Il s’agit comme nous le verrons en détail, d’une nécessaire révolution culturelle à propos de cette démarche, l’accompagnement approfondi des salariés appelés à exercer en télétravail, la contribution de l’entreprise à l’aménagement des espaces adéquats pour le télétravail aux domiciles des salariés, l’usage des Technologies de l’information en version Open source pour s’adapter aux contraintes économiques de l’Afrique subsaharienne et enfin une implication de l’État en matière de législation et de dotation en infrastructures en la matière.
Effect of leptin on aortic dissection
Authors: Chen Ling , Xi Yang , Xu Fan , Chen Liangwan
Published: December 2022

The most important clinical features of aortic dissection (AD) are its acute onset, rapid progress, and high fatality rate. The exact pathogenesis of AD is unclear, and the focus of current research on the mechanism of AD has been primarily on hypertension and changes in metalloproteinases, among which leptin plays an important role. The purpose of this study is to evaluate the effect of leptin on AD. We conducted a computerized literature search on animal studies related to leptin and dissecting aortic aneurysm in PubMed, EMBASE, Cochrane Library, MEDLINE, and other databases from their inception to present. Meta-analysis was conducted to compare the changes in aortic diameter, aortic dilatation, and the incidence of AD in mice under the local intervention of leptin or leptin antagonist (LepA). A total of four studies were included, involving five batches of animal experiments. According to the results of the meta-analysis, the increase in local leptin content led to the enlargement of aortic diameter (relative risk [RR] = 0.18; 95% confidence interval [CI]: 0.09 – 0.27; P < 0.0001) and increased aortic dilatation (RR = 0.11; 95% CI: 0.01 – 0.22; P < 0.0001). This meta-analysis showed that local leptin administration increased the aortic diameter and aortic dilatation. However, due to high heterogeneity between the results, it is difficult to draw a clear conclusion on the effect of leptin on AD.
Penggunaan Model UML Dalam Sistem Informasi Pemesanan Pupuk Berbasis Web (Studi Kasus Pada UD. Bangun Tani Rantauprapat)
Authors: Viktoria Putri Jesica
Published: December 2022

The application of information technology in a business field in this globalization era will have an impact on the results of company performance, because in this globalization era the information produced must be fast, accurate, valid and efficient which is needed by all relevant parts both internal and external to the company which is related. UD.Bangun Tani is a trading company which is engaged in selling various types of fertilizers and pesticides needed in the agricultural sector including plant fertilizers, pesticides, herbicides, vegetable and fruit seeds. UD.Bangun Tani aims to build an information system. Ordering the type of fertilizer based on Web using Localhost and design using the Unifed Lodeling Language (UML) with the existence of this system ordering this fertilizer will be increasingly resolved and managed in a computerized way.
Sistem Informasi Rekam Medis Pada RSU Elpi Al-Aziz Menggunakan Bahasa Pemrograman VB.NET 2010
Authors: Siregar Syah Ramdani
Published: December 2022

RSU Elpi Al-Aziz is an agency engaged in public health services. At RSU Elpi Al-Aziz, in providing services to patients, drug data collection, prescriptions and reports are still done manually or not computerized. Patient data storage media using paper media resulting in the search for data is done by browsing the archives that can take time and prescription making is still done by handwriting where there can be errors recording and making reports related to medical records are still done manually by recording patient data through archives that can take time but it is vulnerable to errors. To support the development method of Medical Record Information System that is made now the author uses the waterfall method by using system development tools in the form of flowcharts, context diagrams, DFD, and database design tools proposed in the form of ERD. As well as data collection techniques with research methods by observation, interviews and literature studies. Implementation of the computer program used in this medical record information system using Visual Basic 2010 programming language with MySQL database that provides facilities to facilitate the process of making information systems and product implementation. The Information System created can overcome the problems that exist in RSU Elpi-Aziz. Storage Media, processing of patient data, medical records, and drugs have been computerized so that the process of public health services can be done quickly and avoid mistakes and facilitate performance at RSU Elpi Al-Aziz.
PENGEMBANGAN KARAKTER PEDULI LINGKUNGAN MELALUI VIDEO STOP MOTION ANIMATION UNTUK SISWA SEKOLAH DASAR
Authors: Bella Aprillianti  , Triyadi Prabowo  , Yenny Aulia Sari  , Arita Marini
Published: December 2022

The purpose of this research is to provide a description and compile a study on the use of stop motion animation videos to develop environmental care characters for elementary school students. The research method used is qualitative research using descriptive analysis techniques with literature studies. In research there are several stages to describe data by collecting data through various sources, such as research articles, books, and other relevant literature. This study shows the results that the application of learning media with stop motion animation videos in the teaching and learning process can be an alternative in developing elementary school students' environmental care character. The model uses stop motion animation video combined with character education based on two-dimensional animation with the theme of keeping the environment clean which gives a message to students to get used to disposing of trash in its place. The use of stop motion animation videos will create learning that can attract students' attention and beautify the appearance of a learning media. Therefore, teachers are expected to be able to make stop motion animation videos to instill the character of caring for the environment in elementary school students through more creative video-making innovations.

Tujuan penelitian ini adalah untuk memberikan deskripsi serta menyusun kajian tentang penggunaan video stop motion animation untuk mengembangkan karakter peduli lingkungan bagi siswa sekolah dasar. Metode penelitian yang digunakan, yaitu penelitian kualitatif menggunakan teknik analisis deskriptif dengan studi literatur. Pada penelitian terdapat beberapa tahapan untuk mendeskripsikan data dengan melakukan pengumpulan data melalui berbagai macam sumber, seperti artikel penelitian, buku, dan literatur lain yang relevan. Penelitian ini menunjukkan hasil bahwa penerapan media pembelajaran dengan video stop motion animation dalam proses belajar mengajar bisa menjadi alternatif dalam mengembangkan karakter peduli lingkungan siswa sekolah dasar. Model menggunakan video stop motion animation dikombinasikan dengan pendidikan karakter berbasis animasi dua dimensi dengan tema jagalah kebersihan lingkungan yang memberikan pesan kepada siswa untuk membiasakan membuang sampah pada tempatnya. Penggunaan video animasi stop motion akan menciptakan pembelajaran yang dapat menarik perhatian siswa dan memperindah tampilan suatu media pembelajaran. Oleh karena itu, guru diharapkan dapat menjadikan video stop motion animation untuk menanamkan karakter peduli lingkungan pada siswa sekolah dasar melalui inovasi-inovasi pembuatan video yang lebih kreatif.
ANALISIS KEPUASAN SISWA, WALI MURID, DAN GURU TERHADAP PEMBELAJARAN PROJEK KURIKULUM MERDEKA KELAS 4 SEKOLAH DASAR
Authors: Nurul khasanah  , Nataria Wahyuning subayani
Published: December 2022

The trial implementation of the learning project for strengthening the Pancasila profile has been carried out in various elementary schools in Indonesia. Therefore, it is necessary to analyze the satisfaction of the learning. This study aims to analyze the level of satisfaction, both for teachers, students, and guardians of students towards learning the Pancasila student profile strengthening project in the independent learning curriculum in grade 4 SD Muhammadiyah 2 GKB Gresik. This type of research is descriptive research using a survey approach method. The variable in this study is satisfaction with learning the independent learning curriculum project. The research was conducted in the 4th grade of SD Muhammadiyah 2 GKB on October 21, 2022. A total of 4 teachers, 26 students, and 26 guardians were selected as research samples by total sampling. Data collection was carried out using a satisfaction index questionnaire. Importance-performance analysis by John A. Martila and John C. James The results of this study indicate that the average student (100.14%), parents (99.96%) and teachers (133 ,42%) satisfied with the learning of the Pancasila profile education strengthening project at the elementary school level at SD Muhammadiyah 2 GKB Gresik. The results of this study are expected to be an evaluation material for curriculum development in schools.
ANALISIS PEMAHAMAN PENJUMLAHAN NILAI UANG DENGAN MODEL KOOPERATIF TALKING STICK PADA SISWA KELAS 2 SDN LONTAR BARU
Authors: Yohana Esra , Syachruroji Ahmad , Rokmanah Siti
Published: December 2022

Pembelajaran di kelas pada siswa sekolah dasar memerlukan suasana belajar yang senang dan menarik minat belajar siswa. Sebagai pendidik diharuskan untuk mengelola kelas dengan kreatif, salah satunya yaitu dapat menggunakan model pembelajaran dan media pembelajaran yang sesuai materi pelajaran agar siswa aktif di kelas. Pada saat pembelajaran terlihat beberapa siswa kurang memahami materi pelajaran dengan baik. Hal tersebut yang menjadikan Penelitian dillakukan dengan melihat masalah yang terdapat yaitu pemahaman siswa terhadap materi penjumlahan nilai uang pada siswa kelas 2 sekolah dasar. Tujuan penelitian ini dilakukan yaitu untuk mengetahui pemahaman siswa terhadap penjumlahan pada nilai uang dan mengetahui perkembangan pemahaman siswa setelah menggunakan model kooperatif talking stick pada materi penjumlahan nilai uang. Penelitian dilakukan menggunakan pendekatan kualitatif, metode deskriptif. Pengambilan data menggunakan triangulasi teknik yaitu berupa wawancara, observasi. Tempat penelitian yaitu di SDN Lontar Baru di kota Serang. Melalui penelitian yang dilakukan diperoleh hasil mengenai pemahaman siswa pada materi penjumlahan nilai uang dan menggunakan model kooperatif talking stick pada materi penjumlahan nilai uang. Pada pemahaman awal siswa mengenai materi penjumlahan nilai uang, terlihat siswa terkendala dalam memahami cara menghitung uang yang jumlah angka sudah ratusan dan ribuan. Kemudian setelah peneliti melakukan pengajaran dengan memberikan penjelasan dan contoh cara menghitung uang, maka siswa cukup memahami materinya. Kemudian peneliti mengajar dengan bantuan model pembelajaran kooperatif talking stick, maka siswa senang belajar dan memahami materi penjumlahan nilai uang. Terlihat juga dari hasil soal evaluasi mandiri yang dikerjakan oleh siswa. Terdapat 14 siswa mendapat nilai terbaik, dan 6 siswa mendapat nilai cukup.
ANALISIS KURANGNYA PEMAHAMAN SISWA KELAS 5 DI SDN LONTAR BARU PADA MATERI PERKALIAN PECAHAN DENGAN MODEL TAKE AND GIVE
Authors: Nurwidianing Susan , Syachruroji Ahmad , Rokmanah Siti
Published: December 2022

Matematika merupakan suatu ilmu yang mengajarkan kita tentang angka-angka dan menjumlahkan nya dalam cara yang berbeda matematika sebagai ilmu pengetahuan yang menunjukan hasil yang realita tidak menduga-duga matematika suatu hal penting bagi kehidupan matematika merupakan ilmu pasti yang dimana ilmu ini menunjukkan hasil yang benar dan tepat tidak mengada-ngada dalam materi matematika banyak sekali cara-cara maupun jenis-jenis yang terkandung dalam pelajaran matematika seperti contohnya perkalian. Dalam hal tersebut matematika menjadi ilmu penting bagi kehidupan banyak sekali permasalahan yang terjadi contohnya di SDN Lontar Baru banyak terjadi nya permasalahan karena minim nya pemahaman serta penguasaan materi perkalian yang terjadi di SDN Lontar Baru. Dengan hal tersebut peneliti menemukan cara untuk mengatasi permasalahan tersebut menggunakan penerapan model take and give model ini sangat berpengaruh untuk siswa yang belum dapat memahami materi perkalian.