bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparative transcriptomics reveals key differences in the response to milk oligosaccharides of infant gut-associated bifidobacteria
Authors: Garrido Daniel , Ruiz-Moyano Santiago , Lemay Danielle G. , Sela David A. , German J. Bruce , Mills David A.
Published: September 2015

Breast milk enhances the predominance of Bifidobacterium species in the infant gut, probably due to its large concentration of human milk oligosaccharides (HMO). Here we screened infant-gut isolates of Bifidobacterium longum subsp. infantis and Bifidobacterium bifidum using individual HMO and compared the global transcriptomes of representative isolates on major HMO by RNA-seq. While B. infantis displayed homogeneous HMO-utilization patterns, B. bifidum were more diverse and some strains did not use fucosyllactose (FL) or sialyllactose (SL). Transcriptomes of B. bifidum SC555 and B. infantis ATCC 15697 showed that utilization of pooled HMO is similar to neutral HMO, while transcriptomes for growth on FL were more similar to lactose than HMO in B. bifidum. Genes linked to HMO-utilization were upregulated by neutral HMO and SL, but not by FL in both species. In contrast, FL induced the expression of alternative gene clusters in B. infantis. Results also suggest that B. bifidum SC555 does not utilize fucose or sialic acid from HMO. Surprisingly, expression of orthologous genes differed between both bifidobacteria even when grown on identical substrates. This study highlights two major strategies found in Bifidobacterium species to process HMO and presents detailed information on the close relationship between HMO and infant-gut bifidobacteria.
A novel bifunctional mitochondria-targeted anticancer agent with high selectivity for cancer cells
Authors: He Huan , Li Dong-Wei , Yang Li-Yun , Fu Li , Zhu Xun-Jin , Wong Wai-Kwok , Jiang Feng-Lei , Liu Yi
Published: September 2015

Mitochondria have recently emerged as novel targets for cancer therapy due to its important roles in fundamental cellular function. Discovery of new chemotherapeutic agents that allow for simultaneous treatment and visualization of cancer is urgent. Herein, we demonstrate a novel bifunctional mitochondria-targeted anticancer agent (FPB), exhibiting both imaging capability and anticancer activity. It can selectively accumulate in mitochondria and induce cell apoptosis. Notably, it results in much higher toxicity toward cancer cells owing to much higher uptake by cancer cells. These features make it highly attractive in cancer imaging and treatment.
Proteomic Changes Associated with Successive Reproductive Periods in Male Polychaetous Neanthes arenaceodentata
Authors: Chandramouli Kondethimmanahalli H. , Reish Donald , Zhang Huoming , Qian Pei-Yuan , Ravasi Timothy
Published: September 2015

The polychaetous annelidNeanthes acuminatacomplex has a widespread distribution, with the California population referred to asN. arenaceodentata. The reproductive pattern in this complex is unique, in that the female reproduces once and then dies, whereas the male can reproduce up to nine times. The male incubates the embryos until the larvae leave the male’s tube 21–28 days later and commences feeding. Reproductive success and protein expression patterns were measured over the nine reproductive periods. The percent success of the male in producing juveniles increased during the first three reproductive periods and then decreased, but the number of juveniles produced was similar through all nine periods. iTRAQ based quantitative proteomics were used to analyze the dynamics of protein expression patterns. The expression patterns of several proteins were found to be altered. The abundant expression of muscular and contractile proteins may have affected body weight and reproductive success. Sperm have never been observed; fertilization occurs within the parent’s tube. Proteins associated with sperm maturation and fertilization were identified, including ATPase, clathrin, peroxiredoxins and enolase, which may provide clues to the molecular mechanisms enabling males to reproduce multiple times.
Evaluation of drug-targetable genes by defining modes of abnormality in gene expression
Authors: Park Junseong , Lee Jungsul , Choi Chulhee
Published: September 2015

In the post-genomic era, many researchers have taken a systematic approach to identifying abnormal genes associated with various diseases. However, the gold standard has not been established and most of these abnormalities are difficult to be rehabilitated in real clinical settings. In addition to identifying abnormal genes, for a practical purpose, it is necessary to investigate abnormality diversity. In this context, this study is aimed to demonstrate simply restorable genes as useful drug targets. We devised the concept of “drug targetability” to evaluate several different modes of abnormal genes by predicting events after drug treatment. As a representative example, we applied our method to breast cancer. Computationally, PTPRF, PRKAR2B, MAP4K3 and RICTOR were calculated as highly drug-targetable genes for breast cancer. After knockdown of these top-ranked genes (i.e., high drug targetability) using siRNA, our predictions were validated by cell death and migration assays. Moreover, inhibition of RICTOR or PTPRF was expected to prolong lifespan of breast cancer patients according to patient information annotated in microarray data. We anticipate that our method can be widely applied to elaborate selection of novel drug targets, and, ultimately, to improve the efficacy of disease treatment.
Water-enhanced Removal of Ciprofloxacin from Water by Porous Graphene Hydrogel
Authors: Ma Jie , Yang Mingxuan , Yu Fei , Zheng Jie
Published: September 2015

An environmentally benign and efficient hydrothermal reduction method was applied for the preparation of three-dimensional (3D) porous graphene hydrogel (GH) adsorbents. The physicochemical properties of GH granules were systematically characterized by transmission electron microscopy (TEM), X-ray diffraction (XRD), Raman spectra and Brunauer-Emmett-Teller (BET) method. GH granules showed an excellent adsorption capacity (235.6 mg/g) for ciprofloxacin via combined adsorption interaction mechanisms (e.g. π-π EDA interaction, hydrogen bonding and hydrophobic interaction). Moreover, reducing the size of the hydrogels can significantly accelerate the adsorption process and enhance the removal efficiency of pollutants from aqueous solution. Water (more than 99 wt%) within hydrogels played a key role in enhancing adsorption performance. The GO hydrogels exhibited an excellent adaptability to environmental factors. These findings demonstrate that GH granules are promising adsorbents for the removal of antibiotic pollutants from aqueous solutions.
Tunable growth of silver nanobelts on monolithic activated carbon with size-dependent plasmonic response
Authors: Zhao Hong , Ning Yuesheng , Zhao Binyuan , Yin Fujun , Du Cuiling , Wang Fei , Lai Yijian , Zheng Junwei , Li Shuan , Chen Li
Published: September 2015

Silver is one of the most important materials in plasmonics. Tuning the size of various silver nanostructures has been actively pursued in the last decade. However, silver nanobelt, a typical one-dimensional silver nanostructure, has not been systematically studied as to tuning its size for controllable plasmonic response. Here we show that silver nanobelts, with mean width ranging from 45 to 105 nm and thickness at ca. 13 nm, can grow abundantly on monolithic activated carbon (MAC) through a galvanic-cell reaction mechanism. The widths of silver nanobelts are positively correlated to the growth temperatures. The width/thickness ratio of the silver nanobelts can be adjusted so that their transversal plasmonic absorption peaks can nearly span the whole visible light band, which endows them with different colours. This work demonstrates the great versatility of a simple, green and conceptually novel approach in controlled synthesis of noble metal nanostructures.
Highly Omnidirectional and Frequency Controllable Carbon/Polyaniline-based 2D and 3D Monopole Antenna
Authors: Shin Keun-Young , Kim Minkyu , Lee James S. , Jang Jyongsik
Published: September 2015

Highly omnidirectional and frequency controllable carbon/polyaniline (C/PANI)-based, two- (2D) and three-dimensional (3D) monopole antennas were fabricated using screen-printing and a one-step, dimensionally confined hydrothermal strategy, respectively. Solvated C/PANI was synthesized by low-temperature interfacial polymerization, during which strong π–π interactions between graphene and the quinoid rings of PANI resulted in an expanded PANI conformation with enhanced crystallinity and improved mechanical and electrical properties. Compared to antennas composed of pristine carbon or PANI-based 2D monopole structures, 2D monopole antennas composed of this enhanced hybrid material were highly efficient and amenable to high-frequency, omnidirectional electromagnetic waves. The mean frequency of C/PANI fiber-based 3D monopole antennas could be controlled by simply cutting and stretching the antenna. These antennas attained high peak gain (3.60 dBi), high directivity (3.91 dBi) and radiation efficiency (92.12%) relative to 2D monopole antenna. These improvements were attributed the high packing density and aspect ratios of C/PANI fibers and the removal of the flexible substrate. This approach offers a valuable and promising tool for producing highly omnidirectional and frequency-controllable, carbon-based monopole antennas for use in wireless networking communications on industrial, scientific and medical (ISM) bands.
Insight into Evolution, Processing and Performance of Multi-length-scale Structures in Planar Heterojunction Perovskite Solar Cells
Authors: Huang Yu-Ching , Tsao Cheng-Si , Cho Yi-Ju , Chen Kuan-Chen , Chiang Kai-Ming , Hsiao Sheng-Yi , Chen Chang-Wen , Su Chun-Jen , Jeng U-Ser , Lin Hao-Wu
Published: September 2015

The structural characterization correlated to the processing control of hierarchical structure of planar heterojunction perovskite layer is still incomplete due to the limitations of conventional microscopy and X-ray diffraction. This present study performed the simultaneously grazing-incidence small-angle scattering and wide-angle scattering (GISAXS/GIWAXS) techniques to quantitatively probe the hierarchical structure of the planar heterojunction perovskite solar cells. The result is complementary to the currently microscopic study. Correlation between the crystallization behavior, crystal orientation, nano- and meso-scale internal structure and surface morphology of perovskite film as functions of various processing control parameters is reported for the first time. The structural transition from the fractal pore network to the surface fractal can be tuned by the chloride percentage. The GISAXS/GIWAXS measurement provides the comprehensive understanding of concurrent evolution of the film morphology and crystallization correlated to the high performance. The result can provide the insight into formation mechanism and rational synthesis design.
Differential Contributions of Nonmuscle Myosin II Isoforms and Functional Domains to Stress Fiber Mechanics
Authors: Chang Ching-Wei , Kumar Sanjay
Published: September 2015

While is widely acknowledged that nonmuscle myosin II (NMMII) enables stress fibers (SFs) to generate traction forces against the extracellular matrix, little is known about how specific NMMII isoforms and functional domains contribute to SF mechanics. Here we combine biophotonic and genetic approaches to address these open questions. First, we suppress the NMMII isoforms MIIA and MIIB and apply femtosecond laser nanosurgery to ablate and investigate the viscoelastic retraction of individual SFs. SF retraction dynamics associated with MIIA and MIIB suppression qualitatively phenocopy our earlier measurements in the setting of Rho kinase (ROCK) and myosin light chain kinase (MLCK) inhibition, respectively. Furthermore, fluorescence imaging and photobleaching recovery reveal that MIIA and MIIB are enriched in and more stably localize to ROCK- and MLCK-controlled central and peripheral SFs, respectively. Additional domain-mapping studies surprisingly reveal that deletion of the head domain speeds SF retraction, which we ascribe to reduced drag from actomyosin crosslinking and frictional losses. We propose a model in which ROCK/MIIA and MLCK/MIIB functionally regulate common pools of SFs, with MIIA crosslinking and motor functions jointly contributing to SF retraction dynamics and cellular traction forces.
Higher blood hematocrit predicts hyperuricemia: a prospective study of 62897 person-years of follow-up
Authors: Zeng Chao , Wei Jie , Yang Tuo , Li Hui , Xiao Wen-feng , Luo Wei , Gao Shu-guang , Li Yu-sheng , Xiong Yi-lin , Lei Guang-hua
Published: September 2015

This prospective study aimed to investigate the relationship between higher hematocrit (Hct) level and hyperuricemia (HU) incidence. A total of 27540 subjects were included. Baseline Hct was classified into four categories based on the quartile distribution of the study population. A cox proportional hazards regression was used to evaluate the risk of HU incidence across the Hct quartiles after adjusting a number of potential confounding factors. Out of the 62897 person-years of follow-up, 2745 new cases of HU were developed. In models adjusted for known risk factors of HU, higher Hct was used to predict HU incidence independently in a graded manner (p = 0.02): compared with subjects in the lowest quartile, subjects in the highest quartile of Hct (hazard ratio = 1.20; 95% confidence interval: 1.03–1.41) were n20% more likely to develop HU. Sensitivity analysis indicated that the hazard ratios increased with the extension of the minimum follow-up interval. When the minimum follow-up interval was restricted to 4 years, subjects in the highest quartile of Hct were 70% more likely to develop HU, compared with the lowest quartile. Higher Hct, a routinely measured inexpensive biomarker was independently associated with the incidence of HU even within the normal range.
Mechanisms for Enhanced Hydrophobicity by Atomic-Scale Roughness
Authors: Katasho Yumi , Liang Yunfeng , Murata Sumihiko , Fukunaka Yasuhiro , Matsuoka Toshifumi , Takahashi Satoru
Published: September 2015

It is well known that the close-packed CF3-terminated solid surface is among the most hydrophobic surfaces in nature. Molecular dynamic simulations show that this hydrophobicity can be further enhanced by the atomic-scale roughness. Consequently, the hydrophobic gap width is enlarged to about 0.6 nm for roughened CF3-terminated solid surfaces. In contrast, the hydrophobic gap width does not increase too much for a rough CH3-terminated solid surface. We show that the CF3-terminated surface exists in a microscopic Cassie–Baxter state, whereas the CH3-terminated surface exists as a microscopic Wenzel state. This finding elucidates the underlying mechanism for the different widths of the observed hydrophobic gap. The cage structure of the water molecules (with integrated hydrogen bonds) around CH3 terminal assemblies on the solid surface provides an explanation for the mechanism by which the CH3-terminated surface is less hydrophobic than the CF3-terminated surface.
Columnar grown copper films on polyimides strained beyond 100%
Authors: Sun Jeong-Yun , Lee Hae-Ryung , Hwan Oh Kyu
Published: September 2015

Many flexible electronic devices contain metal films on polymer substrates to satisfy requirements for both electrical conductivity and mechanical durability. Despite numerous trials to date, the stretchability of metal interconnects remains an issue. In this paper, we have demonstrated a stretchable metal interconnect through control of the texture of a copper film with columnar grown grains on a polyimide (PI) substrate. The columnar grown copper films (CGC films) were deposited by regulating radio frequency (RF) sputtering powers. CGC films were able to sustain their electrical conductivity at strains above 100%. Instead of ultimate electrical discontinuity by channel crack propagation, CGC films maintained their conductivity by forming ligament structures, or a ‘conductive net,’ through trapped micro-cracks. XRD, AFM and in situ SEM analysis were used to investigate these stretchable conductors.
Tailored sunlight driven nano-photocatalyst: bismuth iron tungstate (BiFeWO6)
Authors: Radha R. , Srinivasan A. , Manimuthu P. , Balakumar S.
Published: September 2015

The challenge in employing tungstates for photocatalytic water splitting is to position their conduction band offset with that of the redox potential.
A fully automated analyzer for multiple detection of allergen-specific immunoglobulin E
Authors: Oh Jae Hoon , Park Moon Kyoo , Kim Seong Wook , Park Je-Kyun
Published: September 2015

A tilting carousel technology was developed for fully automated multiple allergy tests, including strip positioning, reagent shaking, and waste aspirating.
Aggregation-based detection of M. smegmatis usingd-arabinose-functionalized fluorescent silica nanoparticles
Authors: Jayawardana Kalana W. , Wijesundera Samurdhi A. , Yan Mingdi
Published: September 2015

d-Arabinose-conjugated nanoparticles interacted strongly withMycobacterium smegmatisand caused the bacteria to aggregate. Mycobacteria at concentrations as low as 104CFU per mL were detected by this aggregation method.
Synthesis of spiro[2.5]octa-4,7-dien-6-one with consecutive quaternary centers via 1,6-conjugate addition induced dearomatization of para-quinone methides
Authors: Gai Kuo , Fang Xinxin , Li Xuanyi , Xu Jinyi , Wu Xiaoming , Lin Aijun , Yao Hequan
Published: September 2015

Spiro[2.5]octa-4,7-dien-6-one with consecutive quaternary centers was synthesized in one pot without the use of metals.
5,5′-Diamino-BIPHEP ligands bearing small selector units for non-covalent binding of chiral analytes in solution
Authors: Storch G. , Siebert M. , Rominger F. , Trapp O.
Published: September 2015

A dynamic axially chiral BIPHEP-ligand with 3,5-dichlorobenzoyl amide selector units for non-covalent binding of phenylalanine derivatives has been developed.
Diastereo- and enantioselective direct vinylogous Michael addition of γ-substituted butenolides to 2-enoylpyridines catalyzed by chiral bifunctional amine-squaramides
Authors: Wang Zhen-Hua , Wu Zhi-Jun , Huang Xue-Qun , Yue Deng-Feng , You Yong , Xu Xiao-Ying , Zhang Xiao-Mei , Yuan Wei-Cheng
Published: September 2015

The enantioselective vinylogous Michael addition of γ-substituted butenolides to 2-enoylpyridines was developed to yield γ,γ-disubstituted butenolide derivatives in excellent stereoselectivities.
Dynameric asymmetric membranes for directional water transport
Authors: Zhang Yan , Barboiu Mihail
Published: September 2015

Template induced phase segregation of the hydrophobic/hydrophobic dynameric frameworks for asymmetric membrane preparation.
Synthesis of cyclic diborenes with unprecedented cis-configuration
Authors: Bissinger Philipp , Braunschweig Holger , Celik Mehmet Ali , Claes Christina , Dewhurst Rian D. , Endres Sebastian , Kelch Hauke , Kramer Thomas , Krummenacher Ivo , Schneider Christoph
Published: September 2015

The first cyclic and cis-configured diborenes are prepared in a convenient one-pot synthesis.
Correction: Reactivity of a pyridinium-substituted dimethyldihydropyrene switch under aerobic conditions: self-sensitized photo-oxygenation and thermal release of singlet oxygen
Authors: Cobo Saioa , Lafolet Frédéric , Saint-Aman Eric , Philouze Christian , Bucher Christophe , Silvi Serena , Credi Alberto , Royal Guy
Published: September 2015

Correction for ‘Reactivity of a pyridinium-substituted dimethyldihydropyrene switch under aerobic conditions: self-sensitized photo-oxygenation and thermal release of singlet oxygen’ by Saioa Cobo et al., Chem. Commun., 2015, 51, 13886–13889.
A one-step ionic liquid-assisted ultrasonic method for the preparation of BiOCl/m-BiVO4 heterojunctions with enhanced visible light photocatalytic activity
Authors: Yang Chengyu , Li Feng , Li Taohai
Published: September 2015

An ionic liquid-assisted ultrasonic method was developed to prepare BiOCl/m-BiVO4 heterojunctions with high photocatalytic activity under both visible light and sunlight irradiation.
{100} → {111} morphological change in KCl crystals grown from Pb2+-doped aqueous solutions
Authors: Pastero L. , Cossio R. , Aquilano D.
Published: September 2015

Sylvite crystals are grown from solution in the presence of lead. An epitaxial model explains both habit and surface modifications.
Influence of hydration on ion–biomolecule interactions: M+(indole)(H2O)n(M = Na, K; n = 3–6)
Authors: Ke Haochen , Lisy James M.
Published: September 2015

Structural configurations of cation–indole–water complexes, M+(indole)(H2O)n.
Theoretical vibrational spectra of OH−(H2O)2: the effect of quantum distribution and vibrational coupling
Authors: Ogata Yudai , Kawashima Yukio , Takahashi Kaito , Tachikawa Masanori
Published: September 2015

Quantum distribution of OH−(H2O)2 and the vibrational spectra computed using these geometries.
Density-functional calculations of the conversion of methane to methanol on platinum-decorated sheets of graphene oxide
Authors: Wu Shiuan-Yau , Lin Chien-Hao , Ho Jia-Jen
Published: September 2015

The calculated optimum potential-energy diagram of methane conversion on (a) Pt2/GO, (b) Pt2O/GO, and (c) Pt2O2/GO sheets.
Structural and photoluminescence properties of Eu3+doped α-Ag2WO4synthesized by the green coprecipitation methodology
Authors: Pinatti Ivo M. , Nogueira Içamira C. , Pereira Wyllamanney S. , Pereira Paula F. S. , Gonçalves Rosana F. , Varela José A. , Longo Elson , Rosa Ieda L. V.
Published: September 2015

Europium doped silver tungstates α-Ag2−3xEuxWO4(x= 0, 0.0025, 0.005, 0.0075 and 0.01 mol) were synthesized by the coprecipitation method at 90 °C for 30 minutes. PL spectra showed a broad band related to the [WO6] group and characteristic narrow peaks due to the f–f transitions of Eu3+as a result of efficient energy transfer from the matrix.
The impact of the polar core size and external organic media composition on micelle–micelle interactions: the effect on gold nanoparticle synthesis
Authors: Gutierrez Jorge A. , Alejandra Luna M. , Mariano Correa N. , Silber Juana J. , Darío Falcone R.
Published: September 2015

An easy way to modulate reverse micelles as nanoreactors to produce different kinds of gold nanoparticles.
Preparation of hierarchical porous-structured Fe3O4 microspheres for Fischer–Tropsch synthesis
Authors: Zhang Yulan , Ma Longlong , Wang Tiejun , Li Xinjun
Published: September 2015

The synthesized porous structure appears to have improved interparticle connectivity, which enhanced the selectivity for producing C5+ hydrocarbons.
Diversity-oriented synthesis of fused thioglycosyl benzo[e][1,4]oxathiepin-5-ones and benzo[f][1,4]thiazepin-5(2H)-ones by a sequence of palladium-catalyzed glycosyl thiol arylation and deprotection–lactonization reactions
Authors: AL-Shuaeeb Riyadh Ahmed Atto , Galvani Gilles , Bernadat Guillaume , Brion Jean-Daniel , Alami Mouad , Messaoudi Samir
Published: September 2015

An efficient synthesis of thioglycosylated benzo[e][1,4]-oxathiepin-5-one and benzothiazepinone derivatives has been reported.
Regioselective synthesis of fullerene multiadducts via tether-directed 1,3-dipolar cycloaddition
Authors: Zhang Bolong , White Jonathan M. , Jones David J. , Wong Wallace W. H.
Published: September 2015

A class of fullerene bisadducts was synthesized in one-pot over two steps with regioselectivity using tether-directed functionalization approach. In extending this class of materials, interesting variations in regioselectivity was observed when different amino acid reactants were used.
Synthesis of an oligonucleotide with a nicotinamide mononucleotide residue and its molecular recognition in DNA helices
Authors: Göckel A. , Richert C.
Published: September 2015

Nicotinamide mononucleotide incorporated at the terminus of a DNA strand give stabilized triplexes with adenine and guanine as pairing partners.
Electrochemical investigation of the stable chromium species in molten FLINAK
Authors: Peng Hao , Shen Miao , Wang Chenyang , Su Tao , Zuo Yong , Xie Leidong
Published: September 2015

This work proved the stable valence state of Cr in molten FLINAK is Cr(iii) determined by CV and SWV. The conversion of Cr(ii) to Cr(iii) should be attributed to the formation of the more stable species [CrF6]3− identified by Raman spectroscopy.
Recovery of uranium, hafnium and zirconium from petroleum ash leach liquor
Authors: Abd El-Hamid A. M. , Zahran M. A. , Abou Elthana S. M. , Khalid F. M. , Kamal H. M.
Published: September 2015

We investigated the optimum adsorption conditions of uranium, hafnium and zirconium elements from petroleum fly ash leach liquor using Dowex 1×8 as a strong basic anion exchange.
Enhancement of the sensitivity of valacyclovir and acyclovir for their spectrofluorimetric determination in human plasma
Authors: Derayea Sayed M. , Omar Mahmoud A. , Mostafa Islam M. , Hammad Mohamed A.
Published: September 2015

Two rapid, simple and highly sensitive spectrofluorimetric methods have been developed and validated for determination of valacyclovir hydrochloride (VAC) and acyclovir (ACV).
One-step synthesis of isoreticular metal–organic framework-8 derived hierarchical porous carbon and its application in differential pulse anodic stripping voltammetric determination of Pb(ii)
Authors: Xiao Lili , Zhou Shenghai , Hu Guangzhi , Xu Hongbo , Wang Yi , Yuan Qunhui
Published: September 2015

A novel electrochemical sensor for Pb(ii) was constructed based on an IRMOF-8-derived NPC with three-dimensional hierarchy of micro-, meso-, and macropores (BET surface area = 1715 m2 g−1).
Fabrication, characterization, and controlled release of eprinomectin from injectable mesoporous PLGA microspheres
Authors: Shang Qing , Zhai Jianhua , Tian Ruiqiong , Zheng Ting , Zhang Xiaoyun , Liang Xiaoyang , Zhang Jing
Published: September 2015

Batches of mesoporous poly(lactide-co-glycolide) (PLGA) microspheres were fabricated via an O/W emulsion–solvent evaporation method.
Flame retardant and anti-dripping properties of polylactic acid/poly(bis(phenoxy)phosphazene)/expandable graphite composite and its flame retardant mechanism
Authors: Mu Xiaowei , Yuan Bihe , Hu Weizhao , Qiu Shuilai , Song Lei , Hu Yuan
Published: September 2015

Poly(bis(phenoxy)phosphazene) combining with expandable graphite exhibit gaseous phase and condensed phase flame mechanism in PLA matrix.
Transesterification of castor oil with trimethylchlorosilane: simultaneous formation of fatty acid alkyl esters and α-monochlorohydrin
Authors: Malavolti M. , Brandi A. , Salvini A. , Giomi D.
Published: September 2015

The reaction between castor oil and various alcohols in the presence of trimethylchlorosilane (TMSCl) as acidic mediator furnishes simultaneously FAAE (fatty acid alkyl esters) and α-monochlorohydrin in good yields.
Photo tuning of thiophene-2,5-dicarbohydrazide derivatives for their photoalignment ability-molecular modelling studies
Authors: Hegde Gurumurthy , Murausky A. A. , Murauski A. A. , Kukhta I. N. , Adhikari A. V. , Komitov L.
Published: September 2015

Simple way of tuning the photo alinging layers.
De novo synthesis of novel bacteriogenic nanocell particles and its cancer cell compatibility evaluation
Authors: Manikandan Muthu , Ramachandran D. , Chun Sechul
Published: September 2015

This study demonstrates the effective synthesis of nanocell particles of bacterial origin using an eco-friendly ultrasonic approach.
Design, synthesis and biological evaluation of novel unsymmetrical azines as quorum sensing inhibitors
Authors: Chourasiya Sumit S. , Kathuria Deepika , Singh Shaminder , Sonawane Vijay C. , Chakraborti Asit K. , Bharatam Prasad V.
Published: September 2015

In this report, novel unsymmetrical azines have been designed and synthesised by using one pot approach. Further, they were evaluated as quorum sensing inhibitors.
Scaffolds drive meniscus tissue engineering
Authors: Zhang Zheng-Zheng , Jiang Dong , Wang Shao-Jie , Qi Yan-Song , Ding Jian-Xun , Yu Jia-Kuo , Chen Xue-Si
Published: September 2015

The review focuses on the recent research trend on scaffold types and biomedical applications, and perspectives in meniscus tissue engineering.
Near infrared laser-heated electrospinning and mechanical properties of poly(ethylene terephthalate)/multi-walled carbon nanotube nanofibers
Authors: Lee Eui Rang , Cho Jae Whan
Published: September 2015

Carbon nanotube-including poly(ethylene terephthalate) nanofibers with enhanced mechanical properties were electrospun by using near infrared laser-heated electrospinning.
Preparation, electrochemical responses and sensing application of Au disk nanoelectrodes down to 5 nm
Authors: Zhang Yaoyao , Xu Shen , Qian YuanYuan , Yang Xiaosong , Li Yongxin
Published: September 2015

Single Au nano-disk nanoelectrodes with the radii down to 5 nm have been prepared, which can be used to measure ferritin molecules in the amount of ∼3900 molecules or 6.1 zmol.
Enhanced electrical conductivity of Au–LaNiO3 nanocomposite thin films by chemical solution deposition
Authors: Wang H. L. , Ning X. K. , Wang Z. J.
Published: September 2015

Au–LaNiO3 (Au–LNO) nanocomposite films with 3.84 at% Au were firstly fabricated by one-step chemical solution deposition (CSD), and their electrical properties were investigated.
High performance of P(VDF-HFP)/Ag@TiO2 hybrid films with enhanced dielectric permittivity and low dielectric loss
Authors: Xiao Xingrong , Yang Hui , Xu Nuoxin , Hu Liang , Zhang Qilong
Published: September 2015

Ag@TiO2 core–shell nanoparticles were synthesized as fillers using a simple vapor-thermal method and P(VDF-HFP)/Ag@TiO2 composites exhibited enhanced dielectric properties.
A pH-sensitive nanocarrier for co-delivery of doxorubicin and camptothecin to enhance chemotherapeutic efficacy and overcome multidrug resistance in vitro
Authors: Li Zhen , Li Hongmei , Liu Lixiang , You Xinyi , Zhang Chaofeng , Wang Yue
Published: September 2015

A pH-sensitive drug delivery system of HSNPs sealed with ZnO QDs nanocarrier, where the HSNPs have the large hollow interiors for delivering hydrophobic camptothecin and the mesoporous structure for delivering hydrophilic doxorubicin.
High temperature dielectric relaxation anomalies in Ca0.9Nd0.1Ti0.9Al0.1O3−δsingle crystals
Authors: Murugesan G. , Nithya R. , Kalainathan S. , Hussain Shamima
Published: September 2015

We herein report dielectric studies on Ca0.9Nd0.1Ti0.9Al0.1O3−δsingle crystals grown by the optical floating zone technique in the temperature range from room temperature to 660 K.
Mechanism of water separation from a gaseous mixture via nanoporous graphene using molecular dynamics simulation
Authors: Darvishi Mehdi , Foroutan Masumeh
Published: September 2015

Interaction energy between a water molecule with carbon atoms of graphene sheet.
The influence of lateral fluorination and cyanation on the mesomorphism of polycatenar mesogens and the nature of the SmC phase therein
Authors: Smirnova Antonina I. , Heinrich Benoît , Donnio Bertrand , Bruce Duncan W.
Published: September 2015

Several series of tetracatenar mesogens having different lateral substituents (–F, –CN, –CF3) on the central ring have been synthesised and their mesomorphism investigated by polarising microscopy, DSC and small-angle X-ray scattering methods.
Correction: Spin mixed charge transfer states of iridium complex Ir(ppy)3: transient absorption and time-resolved photoluminescence
Authors: Singh Mehata Mohan , Yang Yang , Qu Zong-Jin , Chen Jun-Sheng , Zhao Feng-Jiao , Han Ke-Li
Published: September 2015

Correction for ‘Spin mixed charge transfer states of iridium complex Ir(ppy)3: transient absorption and time-resolved photoluminescence’ by Mohan Singh Mehata et al., RSC Adv., 2015, 5, 34094–34099.
Chromosome-like organization of an asymmetrical ring polymer confined in a cylindrical space
Authors: Jeon Chanil , Kim Juin , Jeong Hawoong , Jung Youngkyun , Ha Bae-Yeun
Published: September 2015

An asymmetric ring polymer in a concentric-shell cylinder shows chromosome-like spatial organization.
Depletion, melting and reentrant solidification in mixtures of soft and hard colloids
Authors: Marzi Daniela , Capone Barbara , Marakis John , Merola Maria Consiglia , Truzzolillo Domenico , Cipelletti Luca , Moingeon Firmin , Gauthier Mario , Vlassopoulos Dimitris , Likos Christos N. , Camargo Manuel
Published: September 2015

Coarse-grained representation of a binary mixture of large star-polymers (blue) and small hard colloids (red).
Synthesis of a 3D hierarchical structure of γ-AlO(OH)/Mg–Al-LDH/C and its performance in organic dyes and antibiotics adsorption
Authors: Li Jia , Zhang Ning , Ng Dickon H. L.
Published: September 2015

We demonstrated an efficient route to synthesize a novel 3D hierarchically porous superstructure composed of edge-to-face stacks of Mg–Al-layered double hydroxide nanosheets, directionally arranged γ-AlO(OH) nanowires and amorphous carbon by a facile biotemplate method.
Facile ion-exchange synthesis of silver films as flexible current collectors for micro-supercapacitors
Authors: Yu Yizhen , Zhang Jian , Wu Xing , Zhu Ziqiang
Published: September 2015

Flexible MSCs were created using the SMIE technique in the open air, and it did not involve any complicated clean-room processes. The MSCs developed in this study offer high power density, high flexibility, and long endurance, especially ultrahigh mechanical strength.
Magnetic particle-based super-hydrophobic coatings with excellent anti-icing and thermoresponsive deicing performance
Authors: Cheng Tiantian , He Ren , Zhang Qinghua , Zhan Xiaoli , Chen Fengqiu
Published: September 2015

The multifunctional superhydrophobic surfaces incorporated with Fe3O4 exhibit excellent anti-icing and active deicing properties.
C2N: an excellent two-dimensional monolayer membrane for He separation
Authors: Zhu Lei , Xue Qingzhong , Li Xiaofang , Wu Tiantian , Jin Yakang , Xing Wei
Published: September 2015

Using the first-principles density functional theory (DFT) and molecular dynamics (MD) simulations, we investigate the He separation performance of a porous C2N monolayer synthesized recently.
Correction: Low-cost and high energy density asymmetric supercapacitors based on polyaniline nanotubes and MoO3 nanobelts
Authors: Peng Hui , Ma Guofu , Mu Jingjing , Sun Kanjun , Lei Ziqiang
Published: September 2015

Correction for ‘Low-cost and high energy density asymmetric supercapacitors based on polyaniline nanotubes and MoO3 nanobelts’ by Hui Peng et al., J. Mater. Chem. A, 2014, 2, 10384–10388.
Mimicking biological phenomena in hydrogel-based biomaterials to promote dynamic cellular responses
Authors: Murphy Nicholas P. , Lampe Kyle J.
Published: September 2015

Novel methods to endow cell-responsiveness into hydrogels are explored and successful work is summarized.
9,9-Diphenyl-thioxanthene derivatives as host materials for highly efficient blue phosphorescent organic light-emitting diodes
Authors: Liu Kunkun , Li Xiang-Long , Liu Ming , Chen Dongcheng , Cai Xinyi , Wu Yuan-Chun , Lo Chang-Cheng , Lien A. , Cao Yong , Su Shi-Jian
Published: September 2015

A series of 9,9-diphenyl-9H-thioxanthene derivatives are reported as host materials in blue phosphorescent OLEDs, giving a maximum power efficiency of 69.7 lm W−1 and an external quantum efficiency of 29.0%.
Sr2Y8(SiO4)6O2:Bi3+/Eu3+: a single-component white-emitting phosphor via energy transfer for UV w-LEDs
Authors: Li Kai , Fan Jian , Shang Mengmeng , Lian Hongzhou , Lin Jun
Published: September 2015

A series of tunable blue-green to white phosphors, Sr2Y8(SiO4)6O2:Bi3+,Eu3+phosphors, preparedviaa Pechini-type sol–gel method have been investigated.
Nodulation outer proteins: double-edged swords of symbiotic rhizobia
Authors: Staehelin Christian , Krishnan Hari B.
Published: September 2015

Rhizobia are nitrogen-fixing bacteria that establish a nodule symbiosis with legumes. Nodule formation depends on signals and surface determinants produced by both symbiotic partners. Among them, rhizobial Nops (nodulation outer proteins) play a crucial symbiotic role in many strain–host combinations. Nops are defined as proteins secreted via a rhizobial T3SS (type III secretion system). Functional T3SSs have been characterized in many rhizobial strains. Nops have been identified using various genetic, biochemical, proteomic, genomic and experimental approaches. Certain Nops represent extracellular components of the T3SS, which are visible in electron micrographs as bacterial surface appendages called T3 (type III) pili. Other Nops are T3 effector proteins that can be translocated into plant cells. Rhizobial T3 effectors manipulate cellular processes in host cells to suppress plant defence responses against rhizobia and to promote symbiosis-related processes. Accordingly, mutant strains deficient in synthesis or secretion of T3 effectors show reduced symbiotic properties on certain host plants. On the other hand, direct or indirect recognition of T3 effectors by plant cells expressing specific R (resistance) proteins can result in effector triggered defence responses that negatively affect rhizobial infection. Hence Nops are double-edged swords that may promote establishment of symbiosis with one legume (symbiotic factors) and impair symbiotic processes when bacteria are inoculated on another legume species (asymbiotic factors). In the present review, we provide an overview of our current understanding of Nops. We summarize their symbiotic effects, their biochemical properties and their possible modes of action. Finally, we discuss future perspectives in the field of T3 effector research.
Targeting cancer metabolism at the plasma membrane by limiting amino acid access through SLC6A14
Authors: McCracken Alison N. , Edinger Aimee L.
Published: September 2015

Rapidly proliferating cancer cells increase flux through anabolic pathways to build the mass necessary to support cell division. Imported amino acids and glucose lie at the apex of the anabolic pyramid. Consistent with this, elevated expression of nutrient transporter proteins is characteristic of aggressive and highly malignant cancers. Because tumour cells are more dependent than their normal neighbours on accelerated nutrient import, these up-regulated transporters could be excellent targets for selective anti-cancer therapies. A study by Babu et al. in a recent issue of the Biochemical Journal definitively shows that SLC6A14 (where SLC is solute carrier) is one such cancer-specific amino acid transporter. Although mice completely lacking SLC6A14 are viable and exhibit normal mammary gland development, these animals are highly resistant to mammary tumour initiation and progression driven by potent oncogenes. Because SLC6A14 is essential for tumour growth yet dispensable for normal development and tissue maintenance, small molecules that block amino acid import through this transporter could be effective and selective anti-cancer agents, particularly as components of rational drug combinations.
LRRK2 and ubiquitination: implications for kinase inhibitor therapy
Authors: Melrose Heather L.
Published: September 2015

Pathogenic mutations and risk variants in LRRK2 (leucine-rich repeat kinase 2) represent the most common genetic cause of familial and sporadic PD (Parkinson's disease). LRRK2 protein is widely expressed throughout the brain and the periphery. Structurally, LRRK2 contains several functional domains, including a dual enzymatic core consisting of a kinase and GTPase domain. Disease-linked variants are found in both these enzymatic domains as well as in the COR [C-terminal of ROC (Ras of complex proteins)] and WD40 protein–protein binding domain. The kinase domain is widely believed to be linked to toxicity, and thus the thrust of pharmaceutical effort has focused on developing LRRK2 kinase inhibitors. However, recent data have suggested that inhibition of LRRK2 activity results in reduced LRRK2 levels and peripheral side effects, which are similar to those observed in homozygous LRRK2-knockout and LRRK2 kinase-dead rodent models. In a recent issue of the Biochemical Journal, a study led by Nichols reveals that dephosphorylation of LRRK2 cellular phosphorylation sites (Ser910/Ser935/Ser955/Ser973) triggers its ubiquitination and subsequent degradation and thus may account for the loss of function phenotypes observed in peripheral tissues in LRRK2-knockout/kinase-dead or inhibitor-treated rodents and primates. Albeit negative from a kinase inhibitor standpoint, the data open new avenues for LRRK2 biology and therapeutic approaches to counteract LRRK2 toxicity.
Telepractice in University Au.D. Programs: Survey of Program Directors
Authors: Wilson Nichelle J. , Seal Brenda C.
Published: September 2015

Permanent hearing loss is a global health care burden; 360 million people, including 32 million (9%) children, have disabling hearing loss (Chadha & Stevens, 2013, p. 2). About 80 percent of these people live in developing nations without access to hearing care services. The American Academy of Audiology (AAA, 2014) has reported “ongoing efforts to explore and enhance the use of telepractice…to expand the availability and accessibility of hearing and balance care” to individuals across the world. The American Speech-Language-Hearing Association (2014c) has also endorsed advances in telepractice for the world's millions with hearing loss and related disorders, and encouraged institutional involvement as a future direction for audiology training. In the first publishing of this nature, this report shares survey responses from 28 of the nation's 74 graduate programs about their inclusion of telepractice in the Clinical Doctor of Audiology (Au.D.) curriculum. Results suggest a slow response from university programs and challenges in addressing telepractice in current course and clinical offerings. Results also support a direction of change to include telepractice in future Au.D. curricula.
Blind source separation based x-ray image denoising from an image sequence
Authors: Yu Chun-Yu , Li Yan , Fei Bin , Li Wei-Liang
Published: September 2015

Blind source separation (BSS) based x-ray image denoising from an image sequence is proposed. Without priori knowledge, the useful image signal can be separated from an x-ray image sequence, for original images are supposed as different combinations of stable image signal and random image noise. The BSS algorithms such as fixed-point independent component analysis and second-order statistics singular value decomposition are used and compared with multi-frame averaging which is a common algorithm for improving image’s signal-to-noise ratio (SNR). Denoising performance is evaluated in SNR, standard deviation, entropy, and runtime. Analysis indicates that BSS is applicable to image denoising; the denoised image’s quality will get better when more frames are included in an x-ray image sequence, but it will cost more time; there should be trade-off between denoising performance and runtime, which means that the number of frames included in an image sequence is enough.
Molecular alignment effect on the photoassociation process via a pump-dump scheme
Authors: Wang Bin-Bin , Han Yong-Chang , Cong Shu-Lin
Published: September 2015

The photoassociation processes via the pump-dump scheme for the heternuclear (Na + H → NaH) and the homonuclear (Na + Na → Na2) molecular systems are studied, respectively, using the time-dependent quantum wavepacket method. For both systems, the initial atom pair in the continuum of the ground electronic state (X1Σ+) is associated into the molecule in the bound states of the excited state (A1Σ+) by the pump pulse. Then driven by a time-delayed dumping pulse, the prepared excited-state molecule can be transferred to the bound states of the ground electronic state. It is found that the pump process can induce a superposition of the rovibrational levels |v, j〉 on the excited state, which can lead to the field-free alignment of the excited-state molecule. The molecular alignment can affect the dumping process by varying the effective coupling intensity between the two electronic states or by varying the population transfer pathways. As a result, the final population transferred to the bound states of the ground electronic state varies periodically with the delay time of the dumping pulse.
Multivariate moment closure techniques for stochastic kinetic models
Authors: Lakatos Eszter , Ale Angelique , Kirk Paul D. W. , Stumpf Michael P. H.
Published: September 2015

Stochastic effects dominate many chemical and biochemical processes. Their analysis, however, can be computationally prohibitively expensive and a range of approximation schemes have been proposed to lighten the computational burden. These, notably the increasingly popular linear noise approximation and the more general moment expansion methods, perform well for many dynamical regimes, especially linear systems. At higher levels of nonlinearity, it comes to an interplay between the nonlinearities and the stochastic dynamics, which is much harder to capture correctly by such approximations to the true stochastic processes. Moment-closure approaches promise to address this problem by capturing higher-order terms of the temporally evolving probability distribution. Here, we develop a set of multivariate moment-closures that allows us to describe the stochastic dynamics of nonlinear systems. Multivariate closure captures the way that correlations between different molecular species, induced by the reaction dynamics, interact with stochastic effects. We use multivariate Gaussian, gamma, and lognormal closure and illustrate their use in the context of two models that have proved challenging to the previous attempts at approximating stochastic dynamics: oscillations in p53 and Hes1. In addition, we consider a larger system, Erk-mediated mitogen-activated protein kinases signalling, where conventional stochastic simulation approaches incur unacceptably high computational costs.
Ion acceleration in shell cylinders irradiated by a short intense laser pulse
Authors: Andreev A. , Platonov K. , Sharma A. , Murakami M.
Published: September 2015

The interaction of a short high intensity laser pulse with homo and heterogeneous shell cylinders has been analyzed using particle-in-cell simulations and analytical modeling. We show that the shell cylinder is proficient of accelerating and focusing ions in a narrow region. In the case of shell cylinder, the ion energy exceeds the ion energy for a flat target of the same thickness. The constructed model enables the evaluation of the ion energy and the number of ions in the focusing region.
Breakdown in hydrogen and deuterium gases in static and radio-frequency fields
Authors: Korolov I. , Donkó Z.
Published: September 2015

We report the results of a combined experimental and modeling study of the electrical breakdown of hydrogen and deuterium in static (DC) and radio-frequency (RF) (13.56 MHz) electric fields. For the simulations of the breakdown events, simplified models are used and only electrons are traced by Monte Carlo simulation. The experimental DC Paschen curve of hydrogen is used for the determination of the effective secondary electron emission coefficient. A very good agreement between the experimental and the calculated RF breakdown characteristics for hydrogen is found. For deuterium, on the other hand, presently available cross section sets do not allow a reproduction of RF breakdown characteristics.