bluuebunny/crossref_metadata_2025 huggingface dataset:
Antiplatelet effect, safety, and pharmacokinetics of vicagrel in patients with coronary artery disease undergoing percutaneous coronary intervention
Authors: Zhao Xin , Ma Sicong , Kang Yi , Tang Chengchun , Liu Bin , Jiang Hong , Zheng Mingqi , Tang Yu , Sun Hongbin , Liu Yongqiang , Lai Xiaojuan , Gong Yanchun , Li Yongguo , Qi Zizhao , Ren Ling , Li Jing , Li Yi , Han Yaling
Published: April 2022

Aims

Vicagrel, a novel antiplatelet prodrug to overcome the residual high platelet reactivity of clopidogrel induced by inactive metabolism and cytochrome P450 (CYP) 2C19 polymorphisms, provides favourable antiplatelet inhibition in healthy volunteers. However, its antiplatelet effect and safety in patients with coronary artery disease (CAD) are unclear.

Methods and results

This was a multicentre, randomized, double-blind, triple-dummy, dose-exploring phase II trial comparing the antiplatelet activity and safety of vicagrel at different doses vs. those of clopidogrel in patients with CAD undergoing percutaneous coronary intervention (PCI). The primary endpoint was inhibition of adenosine diphosphate (ADP)-induced platelet aggregation (%IPA) after loading and maintenance doses (LD/MD) at 28 days. Safety endpoints included adverse events (AEs) and Bleeding Academic Research Consortium-defined any bleeding. Pharmacokinetic (PK) profiles and the influence of CYP2C19 polymorphisms were explored in subgroup analysis. Two hundred and seventy-nine patients diagnosed with stable CAD (51.97%), unstable angina (40.86%), and myocardial infarction (7.17%) were randomized to receive vicagrel 20/5 mg (LD/MD), 24/6 mg, or 30/7.5 mg or clopidogrel 300/75 mg in combination with aspirin. %IPAs on Day 28 were 30.19%, 35.02%, 45.61%, and 32.55% for vicagrel 20/5, 24/6, and 30/7.5 mg and clopidogrel, respectively, and were comparable across all groups (P = 0.0694). The plasma concentration of the vicagrel active metabolite M15-2 had a similar area under curve and Tmax to those of clopidogrel. There were no significant differences in AEs (4.35%, 0%, 1.45%, and 5.56% for vicagrel 20/5, 24/6, and 30/7.5 mg and clopidogrel, P = 0.6667) or any bleeding (13.04%, 14.06%, 11.59%, and 11.11% for vicagrel 20/5, 24/6, and 30/7.5 mg and clopidogrel, respectively, P = 0.95) across four groups. %IPAs and PK profiles of vicagrel did not vary significantly among different CYP2C19 metabolizers.

Conclusion

Vicagrel had comparable antiplatelet effect and safety to clopidogrel in patients with CAD undergoing PCI.
Widespread interspecific phylogenetic tree incongruence between mosquito-borne and insect-specific flaviviruses at hotspots originally identified in Zika virus
Authors: Gaunt Michael W , Pettersson John H-O , Kuno Goro , Gaunt Bill , de Lamballerie Xavier , Gould Ernest A
Published: April 2022

Intraspecies (homologous) phylogenetic incongruence, or ‘tree conflict’ between different loci within the same genome of mosquito-borne flaviviruses (MBFV), was first identified in dengue virus (DENV) and subsequently in Japanese encephalitis virus (JEV), St Louis encephalitis virus, and Zika virus (ZIKV). Recently, the first evidence of phylogenetic incongruence between interspecific members of the MBFV was reported in ZIKV and its close relative, Spondweni virus. Uniquely, these hybrid proteomes were derived from four incongruent trees involving an Aedes-associated DENV node (1 tree) and three different Culex-associated flavivirus nodes (3 trees). This analysis has now been extended across a wider spectrum of viruses within the MBFV lineage targeting the breakpoints between phylogenetic incongruent loci originally identified in ZIKV. Interspecies phylogenetic incongruence at these breakpoints was identified in 10 of 50 viruses within the MBFV lineage, representing emergent Aedes and Culex-associated viruses including JEV, West Nile virus, yellow fever virus, and insect-specific viruses. Thus, interspecies phylogenetic incongruence is widespread amongst the flaviviruses and is robustly associated with the specific breakpoints that coincide with the interspecific phylogenetic incongruence previously identified, inferring they are ‘hotspots’. The incongruence amongst the emergent MBFV group was restricted to viruses within their respective associated epidemiological boundaries. This MBFV group was RY-coded at the third codon position (‘wobble codon’) to remove transition saturation. The resulting ‘wobble codon’ trees presented a single topology for the entire genome that lacked any robust evidence of phylogenetic incongruence between loci. Phylogenetic interspecific incongruence was therefore observed for exactly the same loci between amino acid and the RY-coded ‘wobble codon’ alignments and this incongruence represented either a major part, or the entire genomes. Maximum likelihood codon analysis revealed positive selection for the incongruent lineages. Positive selection could result in the same locus producing two opposing trees. These analyses for the clinically important MBFV suggest that robust interspecific phylogenetic incongruence resulted from amino acid selection. Convergent or parallel evolutions are evolutionary processes that would explain the observation, whilst interspecific recombination is unlikely.
Narrative therapy and continuing bonds enquiry with refugees and asylum seekers: Bridging the past and the future
Authors: Draper Ana , Marcellino Elisa , Ogbonnaya Comfort
Published: April 2022

Refugees and asylum seekers experience throughout their lives numerous losses of various nature. Treating mental health among these communities is challenging owing to language and cultural barriers. In addition, there are specific stressors associated with migration and settlement to be considered. This paper explores the use of the model ‘continuing bonds’ (CB) in two case studies as a form of enquiry. The authors draw upon social constructionist and narrative ideas to provide an enquiry approach that enables clinicians to understand and respond to the numerous losses of one's culture and relationships as a result of migratory grief. This is an emerging enquiry model based on the authors' work with unaccompanied minors which professionals can make use of in responding promptly and treating mental health difficulties within this population, drawing upon both past and present relationships.
Lectio praecursoria
Authors: Galvao Lyra Mariana
Published: April 2022

In this lectio praecursoria, which I presented as part of my doctoral defense at the University of Eastern Finland on 5 November 2021, I delve deep into the Brazilian anti-mining movement to understand the context in which activism take place, their main strategies and course of actions, and their ability to influence the overall mining debate in Brazil in the 2010s. It sheds light on the key challenges faced by groups fighting for more environmental and social justice in mining conflictual situations. More specific, the research covers the 2013–2017 time frame, when discussions on the mining framework and a severe tailings dam failure happened. These two cases are analyzed and their effects on anti-mining activism are explored through a twofold focus on social movements and environmental justice studies. The study contributes to scientific discussions on mining and society by seeking conceptual bridges across political-ecologically oriented studies on social movements against mineral extraction. It also expands, significantly, analyses of social movements in Brazil by contributing to the international comparative literature on the social and environmental impacts of mining, Brazilian and Latin American studies, studies on mining history, sociology of mining, and mining policy.
Mitigated Oxidative Stress and Cognitive Impairments in Transient Global Ischemia using Niosomal Selegiline-NBP delivery
Authors: Jafari Bahareh , Gharbavi Mahmoud , Baghdadchi Yasamin , Manjili Hamidreza Kheiri , Mahmoudi Javad , Jafari-Anarkoli Iraj , Amiri Shayan , Hosseini Mir-Jamal
Published: April 2022

Stroke is the most common reason for adult disabilities and the second ground for death worldwide. Our previous study revealed that selegiline serves as an alternative candidate in transient hypoxia-ischemia. However, aggressive and restless behavior was observed in stroke-induced rats receiving 4 mg/kg selegiline. In comparison, 1 mg/kg selegiline could induce negligible therapeutic effects on mitochondrial dysfunction and histopathological changes. Therefore, we designed oral noisome-based selegiline attached to 4-(4-nitrobenzyl) pyridine to improve transient global ischemia by attenuating cognitive impairments, oxidative stress, and histopathological injury. The investigation was performed in transient hypoxia-ischemia-induced rats by oral administration of nanoformulation containing selegiline (0.25-1 mg/kg) for 4 weeks (3 times a week). Novel object recognition (NOR) was considered to evaluate their cognitive dysfunction. Oxidative stress parameters and brain histopathological assessments were determined following the scarification of rats. Outstandingly, our data demonstrated slower selegiline release from niosomes relative to free drug, which was also in a controlled manner. Our data confirmed significant improvement in cognitive behavior in the NOR test, an increase in glutathione level and total antioxidant power, a decline in MDA and protein carbonyl level, as well as a decreased number of dead cells in histopathological assessment after being exposed to (0.5-1 mg/kg) selegiline-NBP nanoformulation. These data manifested that the selegiline-NBP nanoformulation (0.5-1 mg/kg) could significantly reduce oxidative damage, cognitive dysfunction, and histopathological damage compared to transient hypoxia-ischemia rats, which is 20 times lower than the therapeutic dose in humans. Therefore, the proposed nanoformulation would be capable as an alternative candidate without side effects in stroke.
Lateral stability control system for front two-wheel independent driving electric vehicle
Authors: Shchur Ihor Z.
Published: April 2022

High specific indicators of power and torque of modern electric motors, as well as the relative ease of implementation of electric drive system,determinesthe feasibility of using in electric vehicles independentdrives fortwo or more wheels. The configuration of pure electric vehicleswith two driving front wheels, which is considered in this paper, is still uncommon, but it has the advantage of a radical simplification of transmission and steering mechanism. A specific feature of this configuration is the ability to perform by front-wheel drive systems, in addition to the main function of traction and braking bythe low-level of control, a number of additional functions atthe high-levelof control. In addition to the previously developed functions of the electronic differential, electric strengthening of steering and damping of spring oscillations of the steering mechanism, this paper also adds the function of lateral vehicle stability control in electric vehiclescornering. The article considers a seven-degreeof freedom mathematical model of dynamics of a four-wheeledvehicle and shows how this model can be simplified to a two-degree of freedom model describing the dynamics of antwo-wheeled vehicle. This model is sufficient to assess the lateral stabilityof electric vehiclesin cornering and forformation the reference ofadditional yaw-moment, which would regulate the yaw-rate to prevent the electric vehiclesskidding. On this basis, the structure of the lateral vehicle stabilitysystem was developed, which corrects the electromagnetic torques of the drive motors of the frontwheels to form the desired yaw-moment. For the studied electric vehicles with the set parameters, the dependences of the allowable yaw-rate on the set by a driver electric vehiclesspeed and angle of wheels turn in different traction conditions of wheels with a roadway are calculated. A general functional model of a front driving by twoindependentmotorselectric vehicleswith a two-level control system that performs all the above functions has been developed. In the Matlab/Simulink environment, a computer mathematical model of this electric vehiclewas built and simulation studies were conducted, which demonstrate the operation of the proposed lateral vehicle stabilitysystem.
First-line treatment of patients with HER2-positive metastatic gastric and gastroesophageal carcinoma
Authors: Aktürk Esen Selin , Ergun Yakup , Erol Cihan , Arikan Rukiye , Er Muhammed Muhiddin , Atci Muhammed Mustafa , Topçu Atakan , Uçar Gökhan , Akagündüz Baran , Aykan Musa Bariş , Özen Miraç , Baytemur Naziyet Köse , Özçelik Melike , Şahin Elif , Güven Denizcan , Menekşe Serkan , Ak Naziye , Teker Fatih , Kut Engin , Şakalar Teoman , Alan Özkan , Kaçan Turgut , Turhal Nazim Serdar , Kiliçkap Saadettin , Türker Sema , Şendur Mehmet Ali Nahit , Köstek Osman , Karaağaç Mustafa , Sakin Abdullah , Türk Haci Mehmet , Çağlayan Dilek , Cihan Şener , Açikgöz Yusuf , Uncu Doğan
Published: April 2022

Fluoropyrimidine+cisplatin/oxaliplatin+trastuzumab therapy is recommended for the first-line treatment of HER2-positive metastatic gastric adenocarcinoma. However, there is no comprehensive study on which platinum-based treatment should be preferred. This study aimed to compare the treatment response and survival characteristics of patients with HER2-positive metastatic gastric or gastroesophageal junction (GEJ) cancer who received fluorouracil, oxaliplatin, and leucovorin (mFOLFOX)+trastuzumab or cisplatin and fluorouracil (CF)+trastuzumab as first-line therapy. It was a multicenter, retrospective study of the Turkish Oncology Group, which included 243 patients from 21 oncology centers. There were 113 patients in the mFOLFOX+trastuzumab arm and 130 patients in the CF+trastuzumab arm. The median age was 62 years in the mFOLFOX+trastuzumab arm and 61 years in the CF+trastuzumab arm (P = 0.495). 81.4% of patients in the mFOLFOX+trastuzumab arm and 83.1% in the CF+trastuzumab arm had gastric tumor localization (P = 0.735). The median progression-free survival (PFS) was significantly higher in the mFOLFOX+trastuzumab arm (9.4 months vs. 7.3 months, P = 0.024). The median overall survival (OS) was similar in both groups (18.4 months vs. 15.1 months, P = 0.640). Maintenance trastuzumab was continued after chemotherapy in 101 patients. In this subgroup, the median OS was 23.3 months and the median PFS was 13.3 months. In conclusion, FOLFOX+trastuzumab is similar to CF+trastuzumab in terms of the median OS, but it is more effective in terms of the median PFS in the first-line treatment of HER2-positive metastatic gastric and GEJ cancer. The choice of treatment should be made by considering the prominent toxicity findings of the chemotherapy regimens.
Kemampuan Komunikasi Pustakawan dalam Layanan Informasi di Perpustakaan
Authors: Putri Berti Atika , Dewiyani Cindy
Published: April 2022

Perpustakaan sebagai sumber informasi memiliki strategi penting dan memiliki peluang yang cukup besar dalam bidang kepustakawanan dan diseminasi informasi. Seiring dengan kehidupan masyarakat yang berkembang pesat, perpustakaan harus tanggap terhadap kebutuhan akan informasi. Oleh karena itukomunikasi merupakan hal yang tidak kalah pentingnya dalam ilmu perpustakaan. Dalam sebuah komunikasi akan terdapat unsur yaitu siapa yang menyampaikan, apa yang disampaikan, melalui saluran apa, kepada siapa, dan apa pengaruhnya, ini semua berkaitan dengan kegiatan di perpustakaan khususnya pada layanan informasi yang tidak lain langsung berhadapan dengan pengguna.Komunikasi yang digunakan dalam layanan informasi adalah komunikasi interpersonal dimana komunikasi dengan yang melibatkan orang lain, meliputi sikap empati, keterbukaan, mendukung, positif, dan kesetaraan. Semua lembagaapalagi bagi pustakawan yang memiliki tugas luar biasa dalam melayani pengguna haruslah memiliki kemampuan berkomunikasi yang baik, jika pustakawan memiliki keahlian dan pandai berkomunikasi, maka terciptalah citra positif bagi pengguna itu sendiri dan pengguna menunjukkan sikap positif terhadap pustakawan.Oleh karena itu, semakin baik komunikasi maka semakin baik pula pelayanan dan penyampaian informasi dalam memenuhi kebutuhan informasi yang dibutuhkan oleh para pengguna di perpustakaan.
The effect of improvement of datasets on accuracy achievement in deep learning: an example of disease detection in hops plant
Authors: Tanrıkulu Haluk , Sazlı Murat Hüsnü , Parça Hasan
Published: April 2022

Plant diseases are a major threat to food safety and security. Preventing the loss of money and time is possible with early diagnosis of plant diseases. Recent advances in computer vision have led to successful methods for the early detection of plant diseases. In this research, images of downy mildew (Pseudoperonospora humuli) and powdery mildew (Podosphaera macularis) diseases of hops (Humulus lupulus - hops) plant were collected over the internet and classified with the most successful Convolutional Neural Network (CNN) model. In order to increase the performance of the CNN model, images that do not contribute to learning were removed from the datasets, and optimum datasets were created by adding new images that comply with the rules we determined. The model was trained with a small number of selected images and detected downy mildew and powdery mildew diseases of hops with high performance. In this study, certain rules were determined in the recognition of plant diseases, the collection of diseased leaf images and the creation of the data set. It has been shown that training datasets created by following these rules increase performance in learning.
Novel EDAS-Taguchi and EDAS-Taguchi-Pareto Methods for Wire EDM Process Parametric Selection of Ni55.8Ti (Nitinol) Shape Memory Alloy
Authors: Okponyia Kenechukwu Obinna , Oke Sunday Ayoola
Published: April 2022

The EDAS (evaluation based on distance from average solution) method is a broadly utilized tool for multi-criteria analysis with the ability to handle several conflicting criteria. The Taguchi method is an optimization tool with economic capability in experimentation. This article presents EDAS Taguchi (EDAS-T) method based on EDAS and the Taguchi method. It also presents EDAS Taguchi-Pareto (EDAS-TP) method framed from EDAS and Taguchi-Pareto methods. Furthermore, data from the literature to test the proposed methods are presented, which the results are compared. This research shows that the EDAS method produces the optimum combination of parameters at a run with a current of 4A, pulse on time of 50 µs, pulse off time of 14ms, and powder concentration of 1 g/L. Also, the EDAS-Taguchi method reveals a current of 4A, pulse on time of 60 µs, pulse off time of 14 µs, and powder concentration of 1 g/L. However, the principal result is that using the EDAS Taguchi-Pareto method, the optimal current is 3A, pulse on time is 60 µs, and powder concentration is 0.75g/L. The EDAS Taguchi-Pareto method eliminated the pulse off time and pulse on time, claiming that it is not significant to the system's optimum performance. The principal novelty of this article is that it introduces a mechanism of concurrently optimizing and selecting the wire EDM process parameters using the EDAS-Taguchi-Pareto method. The optimization is parallelly conducted as selection occurs, providing an initial notification to ascertain timely detection and control of local optimality of parameters to global optimization before final selection. This is unlike most evaluations, where optimization is done differently from the selection. This study is the first to develop and use EDAS methods for the WEDM process of Ni55.8Ti shape memory alloy.
Pengembangan Modul Bioteknologi Berbasis Potensi Lokal Cocos nucifera Di Kabupaten Batu-Bara Untuk Kelas XII SMA Negeri 1 Sei.Balai
Authors: Ningrum Retno Dwi Septia , Manalu Kartika , Nurkholida Rambe Riris
Published: April 2022

This study aims to produce a biotechnology module based on local potential Cocos nucifera that meets the criteria of being valid, practical and effective. This research includes research and development (Research and Development). This study uses the ADDIE development model with 5 stages, namely analysis (analysis), design (design), development (development), implementation (implementation) and evaluation (evaluation). The subjects in this study were students in class XII of SMA Negeri 1 Sei.Balai with a total of 34 students. The instrument in this study used a questionnaire to see the validity and practicality of the learning media in the form of a module, while the test of student learning outcomes was in the form of pre-test and post-test to see the level of effectiveness of the developed module. The results of this study indicate that the validity level of the media expert validator is 85% and the validity level of the material expert validator is 88% with a very valid category. The practicality level of the learning module based on the biology teacher's response questionnaire is 97% and the practicality level based on the student response questionnaire is 91% with a very practical category. As for the effectiveness level based on the classical completeness of students at the pre-test stage of 19% with a very poor category, but at the post-test stage an increase of 85% with a good category, then the module based on local potential Cocos nucifera in this biotechnology material can said to be effective.
Developments and Trends in Flow Research over 40 Years: A Bibliometric Analysis
Authors: Zhang Yongfa , Wang Fei
Published: April 2022

Since Dr. Mihaly Csikszentmihalyi outlined the foundation of the flow theory in 1975, the study of flow has grown into a massive multi-disciplinary field. Despite its prevalence in application domains such as human-computer interaction, a holistic overview of flow remains deficient within the academic community. This study aimed to use bibliometric techniques to analyze the vast amount of literature accumulated in flow research. A total of 2622 peer-reviewed documents published between 1982 and 2021 were retrieved from Scopus. The results revealed an exponential rise in the number of publications after the new millennium. Flow theory has been frequently connected with self-determination theory and the technology acceptance model. Co-citation analyses revealed the divergence of emerging virtual domains of flow from conventional physical domains, highlighting an alternative theoretical trajectory. The significance of flow in computer-mediated environments was further corroborated by co-occurrence analyses and citation burst analyses. Eight major themes were identified in the 2622 publications, including three theoretical themes (mechanism, positivity, and health) and five application themes (technology, gaming, sports, creativity, and education). Among these themes, technology and gaming reign supreme. We believe these findings first explicitly shed light on the shift from physical to virtual domains in flow research.
THE LEXICAL EQUIVALENCE VARIETY OF F-WORDS TRANSLATION INTO INDONESIAN : CORPUS-BASED TRANSLATION RESEARCH
Authors: Sianipar Isra F. , Sajarwa Sajarwa
Published: April 2022

Translating the movie subtitle is increasingly recognised as a meaning-making mode and language variety in its own right. However, making the meaning is a difficult task when the word is considered taboo in the target language. Therefore, this study attempts to identify the translation of F-Words which are generally considered taboo in Indonesia. The object material of this study is corpus parallel, OpenSubtitle Corpus 2016 which contains correspondence of English- Indonesian data, and focuses on seeing the F-Words translation. The F-Words in this research consisted of fuck, fucks, fucking, fucked, fucker and its compounds such as motherfucker, motherfuck, and motherfucking. This present study employed translational research which took an interpretative qualitative-quantitative analysis. Based on the analysis, the total occurrences of F-Words in the corpus is 7938 occurrences and showed that there is a variation of lexical equivalence of F-Words translation in Indonesia. The finding reveals that the lexical translation of the F-Words in Indonesian is not restricted to negative or taboo. Furthermore, the analysis on the function of F-Words translation in Indonesian translation shows the flexibility of F-Words which can be employed to show solidarity, emphasis meaning, insult, emotion, failure, and misery
K-Means Performance Optimization Using Rank Order Centroid (ROC) And Braycurtis Distance
Authors: Irwandi Hafiz , Sitompul Opim Salim , Sutarman Sutarman
Published: April 2022

K-Means is a clustering algorithm that groups data based on similarities between data. Some of the problems that arise from this algorithm are when determining the center point of the cluster randomly. This will certainly affect the final result of a clustering process. To anticipate the poor accuracy value, a process is needed to determine the initial centroid in the initialization process. The second problem is when calculating the Euclidean distance on the distance between data. However, this method only gives the same impact on each data attribute. From some of these problems, this study proposes the Rank Order Centroid (ROC) method for initializing the cluster center point and using the Braycurtis distance method to calculate the distance between data. With the experiment K=2 to K=10, the results obtained in this study are the proposed method obtains an iteration reduction of 6.6% on the Student Performance Exams dataset and 19.3% on the Body Fat Prediction dataset. However, there was an increase in iterations on the Heart Failure dataset by 24.2%. In testing the cluster results using the Silhouette Coefficient, this method shows an increase in the evaluation value of 5.9% in the Student Performance Exams dataset. However, the evaluation value decreased by 8.3% in the Body Fat Prediction dataset and 3.3% in the Heart Failure dataset.
Clinical Characteristics at Initial Diagnosis of Korean Patients with Retinitis Pigmentosa
Authors: Hwang Jae Hyeong , Nah Seung Kwan , Lew Young Ju , Kim Chul Gu , Kim Jong Woo , Kim Jae Hui
Published: April 2022

Purpose: To evaluate the clinical characteristics of Korean patients diagnosed with retinitis pigmentosa.Methods: We retrospectively reviewed the medical records of patients diagnosed with retinitis pigmentosa from January 2014 to December 2019. We evaluated age, gender, the chief complaints, posterior subcapsular cataract status, abnormalities on optical coherence tomography, visual field test results, and electrooculograms.Results: A total of 492 eyes of 246 patients were included. The mean patient age was 48.0 ± 16.0 years and the chief complaints were decreased vision and night blindness. The mean logarithm of the minimal angle of resolution (logMAR) best‐corrected visual acuity (BCVA) was 0.31 ± 0.50. The BCVA was 0.5 or better in 368 eyes (74.8%). A total of 328 (71.0%) of 462 eyes that underwent visual field testing exhibited visual field defects within 10º. The mean Arden ratio was 1.28 ± 0.28 for the 242 eyes that underwent electro‐oculography. Optical coherence tomography revealed vitreomacular traction/an epiretinal membrane, cystoid macular edema, and retinal thinning in 135 (27.4%), 48 (9.8%), and 112 (22.8%) eyes, respectively. The ellipsoid zone was intact in 222 eyes (45.1%), disrupted in 220 (44.7%), and absent in 50 (10.2%).Conclusions: Most patients with retinitis pigmentosa exhibited visual acuity of 0.5 or better, but also had central visual field defects. Various abnormalities were noted on optical coherence tomography of most patients.
A Hollow Complete Denture Fabricated Using Neutral Zone Approach for a Severely Resorbed Ridge: A Case Report
Authors: Shende Romal , Deogade Suryakant , Khalikar Arun , Wankhade Sattyam , Mukhopadhyay Pronoy
Published: April 2022

Prosthetic rehabilitation using complete dentures is quite a challenging task when accompanied by severely atrophic ridges. Various modifications are required in the treatment strategy to optimize the prognosis of the finished prosthesis. Moreover, the increased inter-arch space demands the hollowing of the maxillary denture to mitigate the issues in retention due to increased weight. This case report aims to demonstrate a technique used to fabricate a hollow maxillary denture and a mandibular denture using the neutral zone approach in the case of a severely atrophied ridge.
Spatial-Temporal Variability of Vegetation Health During El Niño 2015/2016 and La Niña 2017/2018: A Case Study of Sarawak
Authors: Kemarau Ricky Anak , Eboy Oliver Valentine
Published: April 2022

The El Niño incident in 2015/2016 resulted in a 30% decrease in Gross Domestic Product (GDP) mainly from the agricultural sector. This is due to the El Niño incident which contributed to the prolonged drought for 3 months. This prolonged drought disaster has caused the deterioration of plant health due to a decrease in the amount of rainfall. This study examines and analyzes the spatial-temporal dynamics to identify and delineate the vegetation stress zones in Sarawak. In achieving the objectives of this study Vegetation Health Index (VHI) has been used in studying the changes in monthly space due to changes in Oceanic Niño Index (ONI). This study only focuses on the two occurrences of El Niño in 2015/2016 and La Niña in 2017 and 2018 because the Visible Infrared Imaging Radiometer Suite (VIIRS) data only started operations in 2013 until now. The results of this study offer the discovery of the effect of La Niña on plant health compared to previous studies that only focus on the effects of El Niño (Drought) on plant health. Indirectly, this study can provide information on which areas of the district are severely affected by the occurrence of La Niña and El Niño on plant health.
Correction to Caballo et al. (2021)
Authors: Caballo Vicente , Salazar Isabel , Curtiss Joshua
Published: April 2022

In the article “International application of the «Multidimensional Intervention for Social Anxiety» (MISA) program: I. Treatment effectiveness in patients with social anxiety” by Caballo, V. E., Salazar, I. C., Curtiss, J., Gómez, R. B., Rossitto, A. M., Coello, M. F., Herrera, J. S., Gamarra, O., Sanguino, R., Arias, V. B., Hofmann, S. G., & MISA Research Team (Behavioral Psychology/Psicología Conductual, 2021, Vol. 29, No. 3, pp. 517-547. https://doi.org/10.51668/bp.8321301n), some errors were included in the wording of the Participants section (p. 523) which are detailed in this note. These wording errors did not affect the results obtained in the study in any way.
DOĞRUDAN YABANCI YATIRIM GİRİŞLERİNİN İHRACAT ÜZERİNE ETKİLERİ: G-20 ÜYESİ GELİŞMİŞ VE GELİŞMEKTE OLAN EKONOMİLERİN KARŞILAŞTIRILMASI
Authors: UĞUR Burak , TAŞ Seyhan
Published: April 2022

Doğrudan yabancı yatırımları artırmaya yönelik politikaların temel amacı ulusal ekonomiyi canlandırmak, büyümeyi sürdürülebilir hale getirmek olmakla birlikte, bu amacın gerçekleşme kanallarından biri de ihracat kanalıdır. Doğrudan yabancı yatırımlar ev sahibi ülkenin ihracatını; sermaye, teknoloji, yönetim bilgisi, know how ve özellikle küresel piyasalara erişimi sağlayarak genişletmektedir.2008 küresel krizinin ardından başlayan doğrudan yabancı yatırım ve ihracattaki istikrarsızlıklar günümüzde de devam etmektedir. Bu durumdan hareketle doğrudan yabancı yatırım girişlerinin ihracat üzerindeki uzun dönemli etkisinin tespit edilmesi oldukça önemli bir hale gelmiştir. Bu çalışmada, G-20 üyesi gelişmiş ve gelişmekte olan ülkeler için 1994-2017 yılları arasında doğrudan yabancı yatırım girişlerinin ihracat üzerindeki etkisi dinamik panel veri yöntemiyle tahmin edilmiştir. Analizler sonucu elde edilen bulgular, gelişmiş ekonomilerde doğrudan yabancı yatırım girişlerinin ihracatı etkilemediğini, gelişmekte olan ekonomilerde ise, doğrudan yabancı yatırım girişlerinin ihracat üzerinde pozitif etkili olduğunu göstermektedir.
Morphological and histological study of large intestine in adult local rabbits subjected to starvation
Authors: Al-Kawaz Jenan M. , Jawad Noor Muhsen
Published: April 2022

Starvation is a very serious form of malnutrition characterized by a deficiency in nutrients, vitamins and caloric intake. The present study attempts to detect the effect of starvation on the morphology and histology of large intestine in adult females rabbits. the present study included 25 rabbits,their weight ranged between(1500-1800 gm), divided into one control group and four starved groups (S3, S6, S9 and S12) each contained 5 rabbits.The morphological results of cecum weight in all the starved groups was observed to show significant decrease (P≤0.05) as compared with the control group. The proximal colon weight in the S3, S6 and S12 groups decreased significantly (P≤0.05) as compared with the control group. The weight of the distal colon was found to show significant decrease (P≤0.05) in all the starved groups as compared with the control group. The vermiform appendix weight in the S3, S9 and S12 group was observed to show significant decrease (P≤0.05) as compared with the control group. The weight of the rectum in the S6 and S9 groups was observed to show a significant decrease (P≤0.05) as compared with the control group. The macroscopic observation revealed changes due to starvation stress mostly in the proximal colon.
ANALISIS FAKTOR RIWAYAT KEHAMILAN DAN RIWAYAT BAYI TERHADAP KEJADIAN STUNTING PADA BADUTA USIA 6-24 BULAN DI WILAYAH KERJA PUSKESMAS PALABUHANRATU SUKABUMI TAHUN 2021
Authors: Nurajizah Elis
Published: April 2022

Jumlah balita yang ada di Kecamatan Palabuhanratu sekitar 3128 balita dengan kejadian balita stunting sebanyak 56 balita. Dampak yang terjadi akibat stunting adalah perkembangan kognitif, motorik, dan verbal pada anak tidak optimal, peningkatan kejadian kesakitan dan kematian, postur tubuh yang tidak optimal saat dewasa (lebih pendek dibandingkan pada umumnya) dan kapasitas belajar dan performa yang kurang optimal saat masa sekolah. Tujuan dari penelitian ini adalah untuk mengetahui hubungan antara faktor riwayat kehamilan dan riwayat bayi dengan kejadian stunting pada baduta usia 6-24 bulan di wilayah kerja puskesmas palabuhanratu sukabumi tahun 2021. Metode pengumpulan data menggunakan kuesioner observasi yang diambil dari 56 responden. Metode analisis data yang digunakan dalam penelitian ini adalah analisis hubungan dengan metode chi-square pearson correlation menggunakan aplikasi SPSS Ver.25. Hasil penelitian ini, menunjukan bahwa gizi saat hamil tidak memiliki hubungan terhadap stunting dengan p value 0.105, ASI Ekslusif memiliki hubungan terhadap stunting dengan p value 0.000, dan riwayat penyakit infeksi tidak memiliki hubungan terhadap stunting dengan p value 0.286
Urgensi Peace Guidance dalam Dakwah untuk Mencegah Radikalisme
Authors: Setiawati Rini , Ubaidillah Muhammad
Published: April 2022

Dakwah memiliki makna bagaimana seseorang individu dengan berbagai latar belakang, adat-istiadat maupun budaya, serta konsep pemahaman yang berbeda agar dapat saling bermanfaat bagi sesamanya. Keberagaman pemahaman dapat menjadi sumber permasalahan bagi harmonisasi dalam menjalani hidup, khususnya paham radikalisme. Pencegahan radikalisme dalam proses dakwah menjadi tantangan yang harus dapat dicermati dan dipahami secara konsisten oleh para da’I dengan segala metode pendekatan dakwah yang ada. Salah satunya yakni dengan menggunakan pendekatan peace guidance. Peace guidance yakni bimbingan yang mengutamakan kedamaian sebagai anjuran, ajakan serta arahan agar dapat membantu mencapai kedamaian dalam hidupnya. Peace guidance berawal dari keilmuan peace education sebagai akar pembahasannya. Tujuan penelitian ini merupakan pengembangan metode dakwah dalam layanan bimbingan dan konseling Islam, yakni dengan menggunakan pendekatan peace guidance untuk mencegah paham radikalisme. Hasil penelitian ini diharapkan agar  dakwah dengan menggunakan metode peace guidance dapat berperan aktif dalam mencegah radikalisme.
Komunikasi Islami Terhadap Kepuasan Pengguna Sekolah Islam Terpadu
Authors: Hasmawati Fifi
Published: April 2022

Penelitian ini dilakukan untuk dapat menemukan pengaruh komunikasi islami terhadap kepuasaan pengguna/stockholder pada sekolah islam terpadu. Tujuan penelitian ini  menjelaskan  adanya implikasi Komunikasi Islami pada lembaga  pendidikan islam. Penelitian ini dilakukan untuk menguji secara empirik dan menemukan fakta-fakta serta menguji secara ilmiah tingkat kepuasaan yang dicapai dalam terhadap komunikasi islami sistim pendidikan islam di sekolah islam terpadu, dengan menggunakan etika komunikasi islamdan teori kepuasaan.Metode penelitian yang digunakan adalah explanatory survey method, dengan pendekatan kuantitatif. Populasi dalam penelitian ini adalah seluruh siswa dan wali murid pada sekolah islam terpadu di kota Palembang. Penarikan sampel penelitian ini menggunakan teknik teknik  purposivesamplingdan Cluster Random Sample,untuk menghitungukuran sampel dari populasi  peneliti memakai  cara, cross sectional. Pengumpulan data penelitian  menggunakan angket yang dikumpulkan dari responden dengan ukuran sampel sebanyak 384 responden. Analisis data menggunakan analisi deskripsi Regresi Sederhana.Hasil penelitian terungkap bahwa: “adanya pengaruh tingkat kepuasaan dalam penggunaan komunikasi pada sekolah islam terpadu . Konsep  baru yang dikemukakan dari  hasil penelitian ini, terungkap bahwa “kepuasaan sangat berpengaruh terhadappengguna komunikasi islami pada sekolah  islam terpadu.
Analisis Dampak Penyakit Hasad Bagi Manusia Ditinjau Dari Perspektif Islam
Authors: Jannati Zhila , Hamandia Muhammad Randicha
Published: April 2022

Hasad merupakan sifat tercela yang dapat merugikan diri sendiri dan orang lain. Hasad dapat menghadirkan berbagai penyakit di dalam tubuh dan dapat mengikis pahala kebaikan dari seseorang. Oleh karena itu, manusia hendaknya selalu berusaha dan berdoa kepada Allah swt. agar mendapat perlindunganNya untuk terhindar dari sifat buruk ini. Tulisan ini bertujuan untuk memberikan pemahaman mengenai analisis dampak penyakit hasad bagi manusia ditinjau dari perspektif Islam. Hasil pembahasan dari tulisan ini dampak dari penyakit hasad bagi manusia meliputi dampak fisik seperti gangguan pada kelenjar pankreas, insomnia, letih, capek dan lain sebagainya. Selain itu, dampak dari penyakit hasad dapat berupa dampak psikis, misalnya sedih, merana, merasa tersiksa, tercabik-cabik dan penuh amarah. Selanjutnya, dampak sosial dari sifat hasad dapat meliputi hubungan sosial dengan orang lain menjadi tidak harmonis, terjadinya perselisihan, atau bahkan kehidupan sosialnya dapat menjadi lebih suram lagi karena harus berada di dalam jeruji besi penjara. Terakhir, yang paling utama adalah dampak sifat hasad terhadap kondisi keimanan seseorang di mana hasad dapat berdampak pada lenyapnya pahala kebaikan dari seseorang, dapat menyebabkan ketidaksempurnaan dari iman seseorang dan lain sebagainya.
Audit Komunikasi Organisasi Terhadap Kinerja Rafa Televisi di Universitas Islam Negeri (UIN) Raden Fatah Palembang
Authors: Pertiwi Khoir Annisa , Misnawati Desy , Caropeboka Ratu Mutialela , Wijayani Isna
Published: April 2022

Artikel ini bertujuan untuk memaparkan dan juga menjelaskan tentang audit komunikasi organisasi terhadap kinerja Rafa Televisi di Universitas Islam Negeri (UIN) Raden Fatah. Terdapat empat hasil dari audit komunikasi yang dilakukan. Yakni Pergantian Struktur dan Manajemen Rafa Televisi , Penambahan Sumber Daya Manusia Rafa Televisi, Pengalaman Bertugas Rafa Televisi dan Komunikasi Keseharian Kru Rafa Televisi. Artikel ini diperkuat dengan penelitian mix method dengan model strategi eksplanatoris sekuensial. Beberapa sumber data mempertajam analisa mengenai audit komunikasi yang dilakukan di Rafa Televisi. Hasil dari penelitian ini adalah ada pengaruh antara audit komunikasi organisasi terhadap kinerja Rafa Televisi di UIN Raden Fatah Palembang sebesar 6.8% dengan empat poin penyimpangan yakni, banyak kru yang tidak hadir menunaikan tugas yang telah diberikan dikarenakan kebingungan dengan alur komunikasi yang dijalankan, sehingga muncul rasa malas dan akhirnya tidak mengerjakan tugas, kemudian penambahan sumber daya manusia yang belum cukup memadai yang disebabkan oleh tidak adanya orang yang dianggap cakap untuk mengawasi sumber daya yang ada di Rafa Televisi, pejabat yang terpilih belum memiliki pengalaman dan skill yang mencukupi di bidang penyiaran, serta komunikasi keseharian kru yang belum terjalin dengan baik dikarenakan terdapat kebingungan dengan alur komunikasi yang ada dan seringnya terjadi miscommunication antar sesama.
Leaf Disease Remedy Using CNN Algorithm
Authors: Mehta Jahangir Jepee , Wani Furqaan Ahmad , Ahangar Aamir Ashraf , Kaur Kanwaljeet , H Najmusher
Published: April 2022

Abstract: The proposed method aids in the diagnosis of plant diseases as well as the provision of medicines that may be employed as a defensive machine against them. The file collected from the web is correctly separated, and the various plant types are recognized and named again to produce a suitable record. A test file including several plant ailments is then obtained, which is used to assess the project's accuracy and confidence level. We'll next train our classifier with training data, and the result will be expected with maximum accuracy. We employ a Deep Convolutional Neuronic network (CNN), which consists of many layers for an estimate. A newly designed drone prototypical is also being developed that can be used to provide live updates of huge farming lands. The drone will be equipped with a highresolution photographic camera that will capture the image of the plants, which will be used as a contribution to the software, which will determine whether the plant is healthy or not. We reached a 78 percent accuracy level with our programming and training model. Our programmer provides us with the identity of the plant species, as well as the confidence level of the species and the medicine that may be used to treat it. Keywords: Machine Learning, Leaf Disease, Remedy, CNN
Pain relief as human right to patients with terminal stage cancer
Authors: Aliferis Evaggelos , Gkarani - Papadatou Stamatia
Published: April 2022

According to the World Health Organization (WHO) cancer is the second leading cause of death worldwide and accounts for approximately 9.6 million deaths in 2018. Pain is particularly common and extremely worrying for these patients, especially in metastases. Such a situation imposes an approach that would improve the quality of life and would provide specialized medical care which is, according to WHO, the definition of Palliative Care. There have been many efforts to recognize and establish the human right of pain relief, in order to promote the enforcement of human dignity and the protection of Public Health. However, from the thorough study of the literature on this subject, it emerges that much more could be done in that direction. There is a lag firstly in health policy making to prevent and adopt palliative care in health care and health systems. Secondly, there is also a lag in continuing education of health professionals in the treatment and management of pain, and the information of patients and their relatives about their rights. Another obstacle is the problem in opioid accessibility, that are in the treatment of pain, and finally there are social, cultural and economic problems that are to be resolved. Relief from pain, especially in patients with end-stage cancer, is a major public health and community issue. Good cooperation of all (health scientists, scientists, patients, relatives, governments, international organizations) and the exchange of knowledge and information can overall bring very important changes
that would go beyond any obstacles and would bring us one step closer to conquering the relief from pain at the end of life.
PENINGKATAN DAYA SAING UMKM KÖRAN DI JOMBANG CIPUTAT TANGERANG SELATAN DENGAN APLIKASI NUSANTARAVIEWS
Authors: Susetyarto Martinus Bambang , Santosa Gatot Budi
Published: April 2022

Mitra Usaha Mikro Kecil Menengah (UMKM) adalah warung untuk melayani kebutuhan sehari-hari warga Kampung Gedong, yang ingin ditingkatkan menjadi usaha wisata virtual. Permasalahannya adalah mitra tidak tahu bagaimana caranya melakukan inovasi teknologi yang dapat mendukung bisnis wisata virtual tersebut. Oleh karena itu, mitra memutuskan untuk bekerjasama dengan Tim Pengabdian kepada Masyarakat Universitas Trisakti dalam upaya meningkatkan daya saing Usaha Mikro Kecil Menengah KÖRAN di Jombang, Ciputat, Tangerang Selatan dengan aplikasi nusantaraviews. Atas dasar kerjasama itu, kedua pihak merumuskan program kerja bersama untuk membuat aplikasi website wisata virtual sebagai target utama. Target selanjutnya adalah menguasai teknik pengoperasian, memasarkan bisnis wisata virtual, dan mengembangkan aplikasi lebih lanjut. Metode yang digunakan dalam pengabdian kepada masyarakat ini adalah metode panjat tangga, yakni melakukan persiapan, penyuluhan, pelatihan, pendampingan, demonstrasi, dan penyapihan. Hasil pengabdian kepada masyarakat berupa aplikasi nusantaraviews, dengan pilihan fitur-fitur, seperti (1) penjelajahan kampung adat, (2) pentas seni budaya, (3) pameran karya kreatif, (4) foto pakaian adat, (5) musik Nusantara, (6) obrolan dengan masyarakat adat, (7) wisata kuliner, (8) tenun tradisional, (9) cindera mata, dan (10) sajian kesusastraan Nusantara.
BACK COVER VOL.2 NO.2 2021
Authors: Jurnal AKAL Admin
Published: April 2022

BACK COVER VOL.2 NO.2 2021
FUNCTIONAL PROTEIN PRODUCT FROM SPROUTED LENTIL GRAIN
Authors: АНТИПОВА Л.В. , ДАРЬИН А.О.
Published: April 2022

Недостаток белка в рационе жителей России обусловливает поиск новых белковых ингредиентов для продуктов питания. Существенный интерес представляет использование дешевого отечественного сырья – зерна чечевицы. Цель настоящей работы – разработка технологии функционального белкового продукта из пророщенного зерна красной чечевицы, обогащенного йодом, и исследование его органолептических и физико-химических показателей в сравнении с аналогичными показателями белкового продукта Россоя тофу натуральный, широко представленного в отечественной торговой сети. Для увеличения пищевой и биологической ценности и придания продукту функциональных свойств зерна чечевицы проращивали в растворе йодида калия концентрацией 10 г/л. Установлено, что разработанный белковый продукт из зерна красной чечевицы имеет высокие потребительские свойства, пищевую и биологическую ценность, которая на 35,3% выше, чем в продукте белковом Россоя тофу натуральный. Разработанный продукт с рН 5,6 характеризуется хорошо сбалансированным химическим составом, содержит 9,5% жира, 6% белка. Содержание незаменимых аминокислот в белковом продукте из пророщенного зерна чечевицы составило: валина 4,92, изолейцина 4,09, лейцина 7,26, лизина 5,82, метионина 3,08, треонина 3,54, триптофана 0,6, фенилаланина 4,65 г/100 г белка, что сходно с составом идеального белка. Разработанный белковый продукт содержит 0,165 мг йода на 100 г продукта, что удовлетворяет суточную потребность организма человека в этом микроэлементе.

The lack of protein in the diet of Russian residents determines the search for new protein ingredients for food. Of significant interest is the use of cheap domestic raw materials – lentil grains. The purpose of this work is to develop the technology of a functional protein product enriched with iodine from sprouted grains of red lentils and to study its organoleptic and physico-chemical parameters in comparison with similar indicators of the protein product Rossoya tofu natural, widely represented in the domestic retail network. To increase the nutritional and biological value and give the product functional properties, lentil grains were germinated in a solution of potassium iodide with a concentration of 10 g/l. It was found that the developed protein product from red lentil grains has high consumer properties, nutritional and biological value, which is 35.3% higher than in protein product Rossoya tofu natural. The developed product with a pH of 5,6 is characterized by a well-balanced chemical composition, contains 9,5% fat, 6% protein. The content of essential amino acids in the protein product from sprouted lentil grains was: valine 4,92, isoleucine 4,09, leucine 7,26, lysine 5,82, methionine 3,08, threonine 3,54, tryptophan 0,6, phenylalanine 4,65 g/100 g of protein, which is similar to the composition of the ideal protein. The developed protein product contains 0.165 mg of iodine per 100 g of the product, which satisfies the daily need of the human body for this trace element.