bluuebunny/crossref_metadata_2025 huggingface dataset:
The Efficacy and Safety of Tranexamic Acid Combined with Rivaroxaban in Prevention of Clinical Events in Patients after Total Knee/ Hip Arthroplasty: A Meta-analysis
Authors: Bo Zhandong , Jiang Mingyang , Deng Huachu , Liu Siyi , Xie Xiaoyong
Published: January 2020

Purpose To evaluate the efficacy and safety of tranexamic acid combined with rivaroxaban in prevention of clinical events in patients after TKA/THA through meta-analysis of randomized controlled trials. Materials and Methods RCTs were retrieved from medical literature databases. RR, SMD and 95% confidence intervals (CI) were calculated to compare the primary and safety endpoints. Results In total, 16 articles (23 trial comparisons) were retrieved which contained 2179 patients. In general, 1257 patients (57.7%) were randomized to experimental group whereas 922 patients (42.3%) were randomized to control group. The result showed that TXA combined with rivaroxaban significantly reduce TBL, BTV, BTR and the incidence of MB compared to the control group; there were no significant differences in NMB between experimental group and control group. Conclusions This meta-analysis reveals that TXA combined with rivaroxaban can significantly reduce TBL, BTV, the incidence of blood transfusion and the incidence of MB compared to the control group, which proved that its efficacy and safety are trustworthy.
Cytokine profile in the sputum of subjects with post-tuberculosis airflow obstruction and in those with tobacco related chronic obstructive pulmonary disease
Authors: Elise Guiedem , Guiedem Elise , Pefura-Yone Eric Walter , Ikomey George Mondinde , Nkenfou Céline , Mesembe Martha , Mbanyamsig Yivala Mispa , Bih Chende Hycenta , Greame Jacobs Brendon , Chegou Novel Njweipi , Okomo Marie Claire Assoumou
Published: January 2020

Background: Previous studies have shown that tuberculosis (TB) is a risk factor for chronic airflow limitation. Chronic obstructive pulmonary disease (COPD) is recognized as the result of chronic inflammation, usually related to noxious particles. Post-TB airflow obstruction (post-TB/AFO) and tobacco-related COPD (COPD/tobacco) have the same functional pathway characterized by persistent airflow limitation. We sought to compare the profile of 29 cytokines in the sputum of subjects with post-TB/AFO and those with COPD/tobacco. Results: The forced expiratory volume in the first second (FEV 1 ) and FEV1/forced vital capacity (FEV 1 /FVC) ratio were lower in the COPD/tobacco subgroup compared to the COPD/post-TB subgroup. The stages of the disease were more advanced in COPD / tobacco patients. Among the cytokines, IL-1α, IL-1β, MIP-1β, sCD40L and VEGF levels were higher in COPD patients, compared to the controls with p values ​​of 0.003, 0.0001, 0.03, 0.0001 and 0.02 respectively. When the two COPD subgroups were compared, IL-1α, IL-6, TNF-α and IL-8 levels were higher in the COPD/tobacco subgroup compared to the COPD/post-TB subgroup with p-values ​​of 0.031, 0.05, 0.021 and 0.016 respectively. Conclusion: COPD/tobacco is more severe than post-TB/AFO. The pathogenesis of post-TB/AFO appears to involve the cytokines IL-1RA, IL-1α, IL-1β, IL-17, GRO and sCD40L, while COPD/tobacco involves more cytokines.
A Value Chain Approach to Support Southeast Asian Economic Regionalism
Authors: Jones Craig
Published: January 2020

This article includes an exploration of the economic data sets of the Association of Southeast Asian Nations (ASEAN) Statistics, the World Bank, and the International Monetary Fund, as well as primary regional economic initiatives and agreements to assess the strategic indicators of economic regionalism using thematic analysis. The aim of this research is to determine how Southeast Asian regionalism can circumvent vulnerabilities to another economic crisis in North America and the European Union. To correct such financial vulnerabilities, ASEAN has significantly remolded the region into a single market consisting of a 10-nation integrated production base. The ASEAN Economic Community’s main pillars are the establishment of a regional economic foundation based on comprehensive investment initiatives; the liberalization of capital markets, tariffs, and professional labor; infrastructure connectivity; regional policy integration; and free trade agreements to create a regional value chain as part of a single market and production base. The more attainable this comprehensive value-capture-and-integration process becomes, the more attractive it will appear to the global economic investment community and for business opportunities to establish a robust regional foundation. Although the process appears straightforward, capturing value is not a single phenomenon or method, but rather a multifaceted phenomenon, as explored in this study. The regional integration model seeks profitability within effective cross-border production networks and regional liberalization.
What Does ASEAN Economic Community Bring to Older Workers? Examining Inequality in Old Age in Thailand’s Fast-Ageing Society
Authors: Xu Wenqian , Islam Sikander
Published: January 2020

The ASEAN Economic Community is envisaged to promote economic integration initiatives to create a single market across Southeast Asian member countries. It is acknowledged that the intergovernmental initiatives need to be accommodative to national and regional contexts. Thailand, as a pivotal and active partnership, endeavours to facilitate economic transformation and regional integration within the ASEAN and cope with population ageing in Thai society. Since Thailand has been the third most rapidly ageing country in the world, demographic changes pose new challenges for how to achieve persistent economic growth, productive employment and decent work. This article is based on a qualitative approach to investigate the emergent inequality within and across age cohorts shaped by the AEC structural forces, as well as utilizes reliable secondary data to formulate argumentation, including academic publications, policy analysis, scientific reports. We are particularly concerned about the heterogeneity and poverty in old age from the perspective of cumulative advantages/disadvantages. In conclusion, this article suggests policy recommendations of mitigating inequality in old age and advocates a critical lens to examine how political economic structure shapes older individuals in the labour market.
MODERN POSSIBILITIES OF MEDICAL TREATMENT OF OVERACTIVE BLADDER IN WOMEN
Authors: Apolikhina I. A. , Chochueva A. S. , Saidova A. S. , Gorbunova E. A.
Published: January 2020

Overactive bladder (OAB) is a serious urination disorder which affects at least 17% of the population above 40 years old, of which 56% are women and 44% are men. M-cholinoblockers are the first line therapy and the main treatment for OAB. However, their side effects, along with low efficacy, force women to stop taking the drugs. Activation of beta-3-adrenergic receptors is known toreduce the tone of detrusor muscle in the bladder. This resulted in the invention of mirabegron (Mirabegron, Betmiga, Astellas Pharma Europe, Netherlands), the first drug of a new pharmacologic group (beta-3 adrenergic agonists) for the treatment of OAB. A selective beta-3 agonist, mirabegron has no side effects such as dry mouth, increased intraocular pressure or constipation. Numerous clinical studies demonstrated a reduction in the number of episodes of urinary incontinence and frequent urination in the mirabegron group compared to the placebo group.
CIMICIFUGA RACEMOSA EXTRACT AS AN ALTERNATIVE TO HORMONE THERAPY IN THE MANAGEMENT OF ESTROGEN DEFICIENCIES
Authors: Ledina A. V. , Khamoshina M. B. , Ledin E. V.
Published: January 2020

Estrogen deficiencies manifested by vasomotor symptoms, psychological and emotional disorders, urogenital disorders and other complications may be initiated by age-related (physiological) ovarian failure, or a sharp decline in the production of sex steroids in women treated for breast cancer. That results in a significant reduction in the quality of life of women, including general population, and requires treatment. The article tells about the current principles of menopausal hormone therapy based on the provisions of the global consensus, the potential and advancements in herbal medicine, and highlights debatable topics in the management of menopause.
THE EFFECT OF TREATMENT WITH MIFEPRISTONE ON THE QUALITY OF LIFE OF PATIENTS WITH UTERINE MYOMA
Authors: Levakov S. A. , Sheshukova N. A.
Published: January 2020

Purpose of the study: evaluation of the quality of life of patients with symptomatic uterine myoma up to 12 weeks of gestation against a background of mifepristone 50 mg daily continuously for 3 months.

Material and methods. The prospective study involved 141 patients with uterine myoma who received treatment with mifepristone (Gynestril®) 50 mg continuously for 3 months. In order to evaluate changes in the volume of uterine bleeding, each patient kept a diary where she registered the number of sanitary napkins used. Sonographic examination was used to evaluate the size of the uterus and fibroids. The Visual Analogue Scale (10-point VAS scale) was used to assess the pain intensity. Quality of life of patients and their satisfaction with the therapy was also evaluated by a 10-point VAS scale. The complaints, physical examination data and results of sonographic studies were recorded before and immediately after the end of treatment (1st and 2nd visits).

Study results. Drug therapy with Gynestril® (mifepristone 50 mg) for patients with uterine myoma for 3 months helped to obtain a statistically significant (p < 0.001) improvement across all the evaluated parameters: in a large majority of patients, control of menstrual blood loss was achieved (decreased duration and volume of bleeding), while 85 patients (60.3%) achieved reversible drug-induced amenorrhea, and 43 patients (30.5%) - oligomenorrhea; a large majority of patients achieved reduction of pain severity according to VAS, while in 118 (83.7%) patients the parameter was estimated as “slight pain/no pain” after the end of treatment. According to the ultrasound results, a statistically significant decrease was achieved in the number of displayable fibroids (from 2.1 to 1.9 at an average), the volume of the dominant myoma node (on average by 65% from 37.34 to 13.27 cm3) and of the uterus (an average of 35% from 182.71 to 118.09 cm3). In addition, a vast majority of patients - 99.9% - evaluated the quality of life and satisfaction with treatment as high.

Conclusions. Therefore, the results of the study demonstrate that Gynestril® is highly effective, safe and promising in the pharmaceutical treatment of uterine fibroids.
PROSPECTS FOR THE USE OF MEDICATIONS CONTAINING DICLOFENAC AND B VITAMINS IN THE TREATMENT OF PRIMARY DYSMENORRHEA
Authors: Mezhevitinova E. A. , Mgeryan A. N. , Abakarova P. R. , Dovlethanova E. R.
Published: January 2020

Menstrual irregularities are an eternal female problem, in the treatment of which ever new aspects are opening. One of the most common problems is pain in the abdomen during menstruation. This form of menstrual disorder requires special attention, since, according to different authors, menstrual cramps of various severity are registered by 30 to 75% of women. However, about 10% of women, along with sharp pain, speak about deterioration of the general condition to the extent of temporary disability. Moreover, it is known that pain affects the emotional sphere, mental and general condition of the woman, and as a consequence, the relations within the family, thus making it a relevant healthcare and social problem (Smetnik V.P., Tumilovich L.P., 1998).
CURRENT TREATMENT OPTIONS FOR ANEMIA IN PREGNANT WOMEN (LECTURE)
Authors: Chernov V. M. , Tarasova I. S.
Published: January 2020

Anemia can be detected in women before pregnancy, during pregnancy, after childbirth, during lactation period, requiring the attention of doctors and clinical and laboratory monitoring. Iron deficiency anemia (IDA) is the most common anemia in pregnant women. Accurate diagnosis is needed, since there are other possible anemias (posthemorrhagic, folate deficiency, anemia of chronic diseases). Modern options of IDA treatment are include the use of oral iron preparations (in 90% of pregnant women), intravenous iron preparations (in 10% of pregnant women), erythropoiesis stimulating agents – ESA (in 2% of pregnant women), and red blood cell transfusions in severe cases (in 3% of pregnant women). The history of creation of intravenous iron complexes in the laboratory of C.F. Hausmann, as well as properties of various intravenous iron complex formulations in the historical aspect of their manufacturing process (ferric gluconate, iron dextran, iron sucrose, ferric carboxymaltose) and the negotiation of adverse events are described. Indications for the use of intravenous iron preparations are the following: severe IDA, ineffectiveness or intolerance of oral iron, the presence of gastric or duodenal ulcer or gastrointestinal surgery in the past, contraindications for red blood cell transfusions, use of ESA. The advantages of intravenous ferric carboxymaltose are the possibility to use the high dose of iron preparation (1000 mg, 1 time per week), no need for test dose, the possibility of intravenous administration in 15 minutes. High efficiency, good tolerability of ferric carboxymaltose in the treatment of IDA are shown. Pharmacoeconomic analysis showed the feasibility of administration of ferric carboxymaltose in comparison with the drug of previous generation (iron sucrose). The use of intravenous iron preparations in the treatment of IDA in pregnant women will allow to minimize red blood cell transfusions and to move to the stage of drug replacement therapy.
PREGNANCY PLANNING. VITAMIN D DEFICIT – INFERTILITY, CORRECTION OF VITAMIN D DEFICIT
Authors: Yazykova O. I. , Khilkevich E. G.
Published: January 2020

Study objective. To study the efficacy of the drugs vitamin D at the stage of planning of pregnancy in women with infertility of various etiologies, according to domestic and foreign literature.

Materials and methods. We conducted a search of the literature sources by the keywords “vitamin D”, “infertility”, “pregravid preparation” in domestic and foreign databases: elibrary, Medline/PubMed, Embase, CINAHL. 23 sources were selected.

Study results. Vitamin D plays an important role in the regulation of the menstrual cycle and the reproductive health of women. The prevalence of vitamin D deficiency among women with infertility of various etiologies reaches 69%. It is vital to achieve an adequate level of vitamin D in a woman’s body and to prevent its deficiency.

Conclusion. For all women with infertility at the stage of preparation it is recommended to conduct assessment of adequacy of vitamin D by determination of 25(OH)D in serum and correction of its deficit to achieve levels of 25(OH)D more than 30 ng/ml.
СРАВНЕНИЕ ТОКОЛИЗА ГЕКСОПРЕНАЛИНОМ И АТОЗИБАНОМ
Authors: Баев О. Р. , Васильченко О. Н. , Карапетян А. О. , Тетруашвили Н. К. , Ходжаева З. С.
Published: January 2020

The aim of the study was to compare the efficacy and safety of tocolytic agents - atosiban and hexoprenaline.

Patients and methods: The study included 119 pregnant women with threatening preterm labour between 28 to 34 weeks of gestation. Sixty two pregnant received 62 tocolysis by hexoprenaline and fifty seven - atosiban. There were no differences in the clinical condition of pregnant women and features of preterm labour among groups before start of the tocolysis.

The degree of effectiveness is determined by the duration of the pregnancy prolongation (48 hours, 7 days, more than 14 days).

Results: 9 women of 62 that received hexoprenaline tocolysis (22,6%), and 2 – atosiban (3.5%) failed to prolong the pregnancy for more than 48 hours (p < 0,05). Additionally, 5 women of the hexoprenaline group had premature labour within the first week from the treatment start and eight within 7-14 days. In the group of women with an effective atosiban tocolysis all births took place in a range of more than 7 days from the beginning of tocolysis. Four woman in hexoprenaline group received one repeated course of therapy with this drug (without a loading dose) for 24 hours. In atosiban group full repeated course was conducted in the two cases. Full-term gestation births occurred in 14 women (22.6%) after hexoprenaline tocolysis and in 19 (33.3%) – atosiban (p > 0,05%). On average, atosiban tocolysis allowed to prolong pregnancy by 6.5 days longer than hexoprenaline (p < 0,05).

Conclusion: The results of study has shown that atosiban is more effective than hexoprenaline in pregnancy prolongation for more than 48 hours in threatening preterm labor.
THE EFFECT OF LOW-DOSE DROSPIRENONE AND 17β-ESTRADIOL FOR CORRECTION OF THE MANIFESTATIONS OF CLIMACTERIC SYNDROME IN POSTMENOPAUSAL WOMEN
Authors: Gasparyan S. A. , Drosova L. D. , Khripunova A. A.
Published: January 2020

Vasomotor symptoms are the most common symptoms of menopause, requiring treatment with estrogen and/or progestogen. Recent international guidelines recognize the need to use the lowest effective dose of hormone replacement therapy. Drospirenone (DR) in combination with 17β-estradiol (E2) is used as hormone therapy (HT) for relief the symptoms and prevention of postmenopausal osteoporosis.

The review presents data of 2 large randomized controlled studies that evaluated the lowest effective dose combination DRSP/ E2, the safety of this dose for endometrium, identified features of its pharmacodynamics and pharmacokinetics, depending on various factors. The minimum effective dose for the relief of hot flushes without causing any significant impact on the endometrium is DRSP of 0,25 mg/E2 of 0,5 mg. According to the results of the pharmacokinetic study a correlation between effectiveness of low dose DRSP/E2 with DRSP and E2 exposure levels was showed, and smoking reduces the effectiveness of hormonal therapy. This drug not only copes with moderate to severe hot flushes, but also reduces the incidence of symptoms of vulvovaginal atrophy, improving quality of life.
THE USE OF AN INTERPRETIVE SCHEME IN EXAMINING TWO TURKISH TRANSLATIONS OF DOYLE’S “SPECKLED BAND”
Authors: SÜNER Ahmet , AKTENER İlgın
Published: January 2020

This paper descriptively examines two Turkish translations – one published before Sherlock Holmes was popularized in visual media in the 2000s and one thereafter – of a Sherlock Holmes story entitled “The Adventure of the Speckled Band” by Arthur Conan Doyle to establish how the two translators handled certain aspects of the story deemed important for a literary interpretation. In determining these important aspects, it develops and uses an “interpretive scheme” inspired by Damrosch’s (2003) ruminations on “world literature.” The interpretive scheme contains three aspectual categories, i.e., “referential,” “genre-related” and “stylistic” aspects. The aim of this examination is twofold: first, it seeks to find out whether there are differences between the interpretations of these important aspects in the two translations and if so, whether these differences may be a result of the popularization of Sherlock Holmes. Second, it aims to explore the educational implications of translators’ choices in translating the aforementioned aspects, discussing how the use of an interpretive scheme in the analysis of translations may be helpful in choosing texts for the teaching of English literature to a Turkish-speaking audience.
Evidenciação contábil das entidades sem fins lucrativos de assistência social em Feira de Santana (BA): abordagem à luz das normas brasileiras de contabilidade
Authors: Santana Acmar Feliz dos Santos de , Azevedo Tânia Cristina
Published: January 2020

Objetivo: O trabalho teve como objetivo analisar a conformidade da evidenciação contábil das Organizações sem Finalidade de Lucros (OSFL), portadoras de Certificado de Entidade Beneficente de Assistência Social (CEBAS) em Feira de Santana (BA), à luz das Normas Brasileiras de Contabilidade, mediante adoção da Interpretação Técnica Geral - ITG 2002 (R1).

Metodologia: Trata-se de um estudo qualitativo quanto à sua abordagem, realizado por meio de pesquisa bibliográfica e documental. A etapa empírica da pesquisa foi realizada mediante um levantamento dos dados das Entidades de Assistência Social disponibilizadas no website do Ministério do Desenvolvimento Social (MDS), em seguida coletaram-se as informações contábeis divulgadas, utilizando-se a estatística descritiva para tratamento de dados.

Resultados: A pesquisa demonstrou que o nível de atendimento à ITG 2002 (R1), pode ser considerado razoável, entretanto os achados da investigação revelam que às áreas de gestão administrativo-financeira das Entidades Beneficente de Assistência Social (EBAS) não priorizam elaborar e divulgar as informações contábeis para uso ou para prestar contas aos diversos usuários.

Contribuições do Estudo: A presente pesquisa proporciona contribuições devido a sua fonte de investigação ter sido inspirada nas práticas contábeis previstas na ITG 2002 (R1) adotadas pelas EBAS, podendo o estudo avançar para futuras investigações em entidades que atuam em outros setores.
Level of adherence of the brazilian listed companies of the telecommunications sector to the accounting pronouncement CPC 47
Authors: Rafael Xavier de Oliveira  , Thais Mota Crabbi  , Jomar Miranda Rodrigues
Published: January 2020

Purpose: The present work sought to analyze the level of compliance of the Brazilian companies in the telecommunications sector listed in B3 to accounting pronouncement CPC 47.

Methodology: A checklist was elaborated containing 8 (eight) criteria in which companies should disclose in order to obtain a high level of compliance with CPC 47. It’s characterized as a documentary research with analysis of content over the consolidated financial statements (balance sheet and income statement), explanatory notes and management reports published by the companies in the years 2017 and 2018.

Results: The results show that no company presented adherence to the new standard. The company Telefonica Vivo Brazil was the one with the highest level, 56.25%, while Telebras presented the lowest, 29.16%. In addition, it was checked whether the companies already disclosed their information in accordance with the standard before it became mandatory, as a voluntary disclosure. The companies OI S.A., Telebras and Algar Telecom did not mention CPC 47 in the first three quarters of 2017. On the other hand, Telefonica Vivo Brazil and TIM Holdings alluded to the norm since the first period analyzed.

Contributions of the Study: It’s a current topic in accounting research because it’s the year of implementation of CPC 47, and relevant, as it will bring significant changes in the recognition and disclosure criteria of revenues. From the literature review, few studies have been done dealing with the topic. From this, this research sought to contribute to expand the list of works produced on the new CPC, with a quantitative approach, in the lines of accounting disclosure and regulation.
The impact from adapting of the IFRS 9 (CPC 48) on expected credit losses (ECL) in Brazilian energy companies
Authors: Aline Thatyana Aranda da Rocha Branco Alcantara Alves  , Maria Paula Ribeiro Bordin  , Alexandre Gonzales  , Fernando de Almeida Santos
Published: January 2020

Purpose: To identify the IFRS 9 (CPC 48) adoption impact on Expected Credit Losses, based on historical losses under CPC 38.
Methodology: a documentary, exploratory research was carried out in all the companies of the electric energy sector listed on the Brazilian Stock Exchange, denominated, Brazil, Bolsa, Balcão (B3) of the Novo Mercado (NM), Level 1 (N1) and Level 2 (N2) of corporate governance. Analyzing all the expected losses disclosed in the financial statements, mainly the explanatory notes of 2017 and the first quarter of 2018. For the companies that disclosed these adjustments the Wilcoxon average comparison tests and the Boxplot diagram were performed.
Results: The survey results showed that not all the companies analyzed disclosed the adjustments and the accounting criteria of the SCPPs in the Explanatory Notes, according to CPC 48, and those that disclosed haven´t had a significant impact on the adoption of the new CPC.
Contributions of the Study: This paper contributed to the reflection, understanding and analysis of the adoption, impact and empirical evaluation of the effects of the expected loss models on companies in the electricity sector, corroborating the effects of the Standard CPC 48 (IRFS 9) on the financial statements of companies classified as New Market, starting in January 2018, and may be useful in the process of regulating the segment, in decision-making and possible understanding of its potential effects, particularly in the adequacy of multinational standards. It was verified whether changes in expected losses measurement metrics could result in impacts on net income for the year, as well as changes in the net value of current assets, both of which are relevant to decision making. Such verification is relevant to the managers of the companies and investors, for security in relation to the maintenance of the form of performance verification.
Accounting teaching and the convergence process to international financial reporting standards
Authors: Giovana Bolzan  , Maria Ivanice Vendruscolo  , Jonatas Dutra Sallaberry  , Willian Diehl
Published: January 2020

Purpose: The research analyzes the teaching of accounting sciences in view of the convergence with international accounting standards, from the perspective of scientific production.

Methodology: In the study, the approach of the problem occurs in a qualitative and quantitative methods, concerning the objective in a descriptive way and, regarding the technical procedures, the identification of 21 articles on "teaching" and "IFRS" in the period from 2007 to 2018, which were support for the documental analysis and systematic review. In the development of the proposal, we used content analysis procedures with the categorization of the articles, and their contributions to the discussion.

Results: The results indicate the concern with the curriculum, faculty members and students in the teaching process, in relation to the perception and the acquisition of knowledge. Problems and limitations have been identified in both students and faculty members, but with more consistent results in farther periods from the beginning of convergence to international accounting standards. With Regard to the research, the main researchers of the joint theme Teaching and IFRS, Jorge Niyama, Dulcinéli Botelho and Roberto Carlos Klann, and other authors whose publications on the subject occurred in high quality journals. In general, research on the subject allows the development of networks with the predominance of doctors researchers and space for other researchers in training.

Contributions of the Study: The study reveals the difficulties faced by faculty members and students in the incorporation of new accounting principles and the assimilation of knowledge, indicates gaps in the need for training and improvements in the teaching process in order to increase the quality of accounting teaching. In addition, it indicates potential research gaps and demonstrates that the subject absorbs even researchers in training about research conducted by doctors, denoting the importance of research groups and networks.
Enseñanza de ciencias contables y el proceso de convergencia a las international financial reporting standards
Authors: Giovana Bolzan  , Maria Ivanice Vendruscolo  , Jonatas Dutra Sallaberry  , Willian Diehl
Published: January 2020

Objetivo: La investigación analiza la enseñanza de las ciencias contables en vista de la convergencia con los estándares internacionales de contabilidad, desde la perspectiva de la producción científica.

Metodología: En el estudio, el enfoque del problema se produce de forma cualitativa y cuantitativa, con respecto al objetivo de forma descriptiva y, con respecto a los procedimientos técnicos, la identificación de 21 artículos sobre ‘enseñanza’ y ‘NIIF’ en el período comprendido entre 2007 hasta 2018, que fueron soporte para el análisis documental y la revisión sistemática. En el desarrollo de la propuesta, utilizamos procedimientos de análisis de contenido con la categorización de los trabajos y sus contribuciones a la discusión.

Resultados: Los resultados muestran la preocupación por el currículo, los profesores y los estudiantes en el proceso de enseñanza, en relación con la percepción y la adquisición de conocimientos. Se han identificado problemas y limitaciones tanto en los estudiantes como en los maestros, pero con resultados más consistentes en períodos más alejados del comienzo de la convergencia a los estándares internacionales de contabilidad. Respecto a las investigaciones, los principales investigadores del tema conjunto Docencia y NIIF, Jorge Niyama, Dulcinéli Botelho y Roberto Carlos Klann, y otros autores cuyas publicaciones sobre el tema se publicaron en revistas de alta calidad. En general, la investigación sobre el tema permite el desarrollo de redes con predominio de investigadores y espacio para otros investigadores en formación.

Contribuciones del Estudio: El estudio, que revela las dificultades que enfrentan maestros y estudiantes en la incorporación de nuevos principios contables y la asimilación de conocimientos, indica brechas en la necesidad de capacitación y mejoras en el proceso de enseñanza para aumentar la calidad de la educación contable. Además, señala los posibles vacíos de investigación y demuestra que el sujeto absorbe incluso a los investigadores en formación en investigación llevada a cabo por médicos, lo que denota la importancia de los grupos y las redes de investigación.
As informações contábeis dos balanços versus os indicadores de satisfação de usuários: os casos do Metrô e da CPTM em São Paulo
Authors: Bruna de Morais Holanda  , Lucas Custódio Alexandrino  , Jaime Crozatti
Published: January 2020

Banco de dados brutos de pesquisa.
AS DIFERENTES ABORDAGENS UTILIZADAS PARA DEFINIR BREJOS DE ALTITUDE, ÁREAS DE EXCEÇÃO DO NORDESTE BRASILEIRO
Authors: De Medeiros Jacimária Fonseca , Cestaro Luiz Antonio
Published: January 2020

A Região Geográfica Nordeste do Brasil é muito heterogênea no tocante às condições ambientais, predominando em seu interior as paisagens e os processos naturais associados a um clima semiárido. Fazem parte desse espaço, entretanto, áreas ambientais de exceção, como os Brejos de Altitude, condicionados pela topografia mais elevada, expressão espacial relativamente reduzida e processos naturais distintos daqueles predominantes no seu entorno. Os conceitos de Brejo de Altitude são diferenciados a estão apoiados em enfoques diversos. Nosso objetivo neste trabalho é compilar e discutir os diferentes conceitos de Brejo de Altitude nordestinos, bem como elencar os espaços considerados como tal a partir de indicações de diversos autores. Observamos que o conceito de Brejo de Altitude está apoiado em abordagens morfoclimática, fitogeográfica e/ou sistêmica. São reconhecidos, a partir da literatura especializada, 65 Brejos de Altitude nordestinos.
DINÂMICA IMOBILIÁRIA NA CIDADE DO NATAL/RN
Authors: Oliveira Osmar Faustino , De Carvalho Neto Manoel Raymundo , Pimentel Neto José Geraldo , Miranda de Souza Flávio Antônio
Published: January 2020

A dinâmica imobiliária pode ser definida como uma somatória de processos que evidenciam a transformação e valoração sobre o uso do solo em uma lógica de produção de imóveis construídos ou de lotes ditos urbanizados. O objetivo do presente trabalho é discutir o mercado imobiliário em Natal em uma perspectiva econômica. A metodologia consiste em uma revisão bibliográfica. Por meio dos dados, ficou perceptível que alguns bairros de Natal são mais valorizados do que outros, atraindo assim, maiores investimentos e especulação imobiliária, encarecendo essas áreas, o bairro de Nova Parnamirim é um exemplo.
INTEGRAÇÃO DOS SERVIÇOS DE SAÚDE PÚBLICA NA GESTÃO DE RISCOS DE DESASTRES NATURAIS:
Authors: Moura Sherelee Ribeiro Spindola de , Vieira Rafaela
Published: January 2020

A relação entre políticas de saúde pública e a gestão de riscos de desastres naturais (GRD) passa pelo fortalecimento do Sistema Único de Saúde, em especial pela atuação da atenção primária.  Por isso, objetivou-se apontar oportunidades e desafios relacionados à atuação dos agentes comunitários de saúde (ACSs) no contexto de integração entre os serviços de saúde púbica e a GRD. Aplicaram-se entrevistas semiestruturadas aos ACSs que possuem mais tempo de atuação em Unidades Básicas de Saúde localizadas em áreas de alta e média suscetibilidade aos riscos de inundação, enxurrada e/ou movimentos gravitacionais de massa no município de Blumenau-SC. Os resultados revelam que os ACSs possuem um forte embasamento territorial e vínculo com a comunidade. Este aspecto poderia ser mais bem explorado em políticas que busquem a integração dos serviços de saúde na gestão de riscos de desastres naturais em suas diferentes escalas.
ORGANIZAÇÃO DAS REDES DE COMÉRCIO VAREJISTA DE MÓVEIS E ELETRODOMÉSTICOS NO ESTADO DO CEARÁ:
Authors: Batista Moreira Tiago
Published: January 2020

Resumo

Tendo em vista as tendências de evolução do setor varejista no Estado do Ceará, não apenas a metrópole, mas também diversas cidades do interior do Estado se inserem em um raio de ação do capital que seleciona e julga os mercados propícios a investimentos. São empresas que reestruturam pontualmente a economia urbana e que a partir do século XXI passaram por intensas transformações influenciadas por um cenário macroeconômico instável, onde as especificidades territoriais no momento de expansão das redes se configuraram como importantes fatores de manutenção e ampliação dos lucros. Posto isso, o artigo tem como objetivo analisar a organização das redes varejistas no território cearense e as interações espaciais que se dão nesse processo através do estudo de caso de três importantes redes do varejo de móveis e eletrodomésticos locais, são elas Zenir, Macavi e Rabelo.

Palavras-chaves: comércio. redes varejistas. Ceará. interações espaciais.
O TURISMO NO RIO GRANDE DO NORTE
Authors: Berto de Almada José Alexandre
Published: January 2020

O presente artigo discute a invenção de um turismo no Rio Grande do Norte, a partir da produção do espaço geográfico, com base nas das políticas públicas relacionadas ao turismo e dados do MTUR e da SETUR, entre 1980 e 2017. O PRODETUR/NE aplicou no estado US$ 75,7 milhões, contribuindo diretamente para estruturar a atividade turística, porém, concentrando em Natal, e municípios vizinhos, os investimentos, em função da escolha pelo modelo de turismo de massa de sol e praia.  No restante do estado o turismo não é uma atividade econômica significativa. A invenção do turismo no lugar é amálgama entre o Estado, o Mercado e os turistas, porém, quando uma dessas variáveis é improfícua ou ausente, a atividade turística não consegue ser uma opção para o desenvolvimento local ou estadual.
1, 1’-Sulfinyldiethylammonium Bis (Hydrogen Sulfate) as a Recyclable Dicationic Ionic Liquid Catalyst for the Efficient Solvent-free Synthesis of 3, 4-Dihydropyrimidin-2(1H)-ones via Biginelli Reaction
Authors: Ehsani-Nasab Zainab , Ezabadi Ali
Published: January 2020

Objective:

A facile and efficient method for synthesis of 3, 4-dihydropyrimidin-2(1H)-ones via
Biginelli reaction catalyzed by a novel dicationic Brönsted acidic ionic liquid, [(EtNH2)2SO][HSO4]2, has
been successfully developed.

Material and Method::

3, 4-Dihydropyrimidin-2(1H)-ones were synthesized through one-pot
condensation of aromatic aldehydes, ethyl acetoacetate, and urea under solvent-free conditions using
[(EtNH2)2SO][HSO4]2
as a novel catalyst. The progress of the reaction was monitored by thin-layer
chromatography (ethyl acetate / n-hexane = 1 / 5). The products have been characterized by IR, 1H NMR,
13C NMR, and also by their melting points.

Results:

In this research, a library of dihydropyrimidinone derivatives was synthesized via Biginelli
reaction under solvent-free conditions at 120oC using [(EtNH2)2SO][HSO4]2
as a catalyst. Various aromatic
aldehydes, as well as heteroaromatic aldehydes, were employed, affording good to high yields of the
corresponding products and illustrating the substrate generality of the present method. In addition, the
prepared dicationic Brönsted acidic ionic liquid can be easily recovered and reused.

Conclusion:

1, 1’-Sulfinyldiethylammonium bis (hydrogen sulfate), as a novel dicationic ionic liquid, can
act as a highly efficient catalyst for the synthesis of 3, 4-dihydropyrimidin-2(1H)-ones under solvent-free
conditions.
Green Route for the Removal of Pb from Aquatic Environment
Authors: Refaat Ahmed , Elhaes Hanan , Ammar Nabila S. , Ibrahim Hanan S. , Ibrahim Medhat
Published: January 2020

Aim and Objective:

Wastewater treatment/remediation is a very important process that
has a great environmental and economic impact. Therefore, it is crucial to innovate different
methods to remove pollutants of different sources from wastewater. This work was conducted in
order to study the removal of lead (Pb+2) from wastewater using microspheres of composites of
sodium alginate, cellulose and chitosan, as well as using a cost-effective green route through
composites of sodium alginate and dried water hyacinth.

Materials and Methods:

Molecular modeling at B3LYP/6-31g(d,p) was utilized to study sodium
alginate, cellulose and chitosan. Sodium alginate was cross-linked with calcium chloride to form
microspheres, then both sodium alginate/cellulose and sodium alginate/chitosan were also crosslinked
as 50/50 to form microspheres. The roots of the aquatic plant water hyacinth in dry form
were added to the cross-linked sodium alginate for up to 70%. SEM and FTIR were employed to
study the surface of the prepared microspheres and their structures respectively. Atomic absorption
spectroscopy was used to study the levels of Pb.

Results:

Molecular modeling indicated that the blending of such structures enhances their ability to
bind with surrounding molecules owing to their ability to form hydrogen bonds. SEM results
indicated that homogeneous structures of cellulose and chitosan are deformed when blended with
sodium alginate, and FTIR confirmed the proper formation of the desired blends. Microspheres
from sodium alginate showed the ability to remove Pb+2 from wastewater. SEM indicated further
deformation in the morphology with the roughness of sodium alginate/water hyacinth
microspheres, while FTIR confirmed the uniform matrices of the microspheres. The removal of
Pb+2 was enhanced because of the addition of dried water hyacinth's roots.

Conclusion:

Modeling, experimental and kinetic data highlight sodium alginate/water hyacinth
root as a green route to remediate Pb+2 from wastewater.
The Potential Role of Tea in Periodontal Therapy: An Updated Review
Authors: Forouzanfar Ali , Mohammadipour Hamideh Sadat , Forouzanfar Fatemeh
Published: January 2020

Periodontal diseases are highly prevalent and can affect high percentage of the worlds’
population. Oxidative stress and inflammation play an important role in the pathogenesis of periodontal
diseases. Nowadays, more attention has been focused on the herbal remedies in the field of
drug discovery. Green tea is an important source of polyphenol antioxidants. It has long been used
as a beverage worldwide. The most interesting polyphenol components of green tea leaves that are
related with health benefits are the catechins. Taken together, this review suggested that green tea,
with its wide spectrum of activities, could be a healthy alternative for controlling the damaging reactions
seen in periodontal diseases.
Quantitative Color Doppler Ultrasonography Measurement of Thyroid Blood Flow in Patients with Graves’ Disease
Authors: Yuksekkaya Ruken , Celikyay Fatih , Gul Serdar S. , Yuksekkaya Mehmet , Kutluturk Faruk , Ozmen Cansel
Published: January 2020

Background:

Graves’ Disease is an autoimmune disorder characterized by increased
levels of thyroid hormones correlated with increased thyroid blood flow. Thyroid scintigraphy is an
important and conventional method. However, it has limited accessibility, has ionizing radiation,
and is expensive.

Objectives:

To investigate the thyroid blood flow in patients with Graves’ Disease by color Doppler
Ultrasonography and a newly developed software Color Quantification.

Methods:

Forty-one consecutive subjects with GD and 41 healthy controls were enrolled. Color
Doppler ultrasonography parameters of the thyroid arteries and Color Quantification values of the
gland were measured by a radiologist. The correlations between thyroid blood flow parameters,
levels of 99mTechnetium pertechnetate uptake, thyrotropin, and free thyroxine were evaluated. The
diagnostic performances of these parameters were investigated.

Results:

The peak systolic-end diastolic velocities of thyroid arteries and Color Quantification values
were increased in the study group (p < 0.05 for all). We observed negative correlations between
thyrotropin levels and peak-systolic and end-diastolic velocities of superior thyroid arteries and
Color Quantification values. There were positive correlations between 99mTechnetium uptake levels
and thyroid blood flow parameters (p < 0.05 for all). In the diagnostic performance of thyroid blood
flow parameters, we observed utilities significantly in peak-systolic and end-diastolic velocities of
thyroid arteries and Color Quantification values (p < 0.05 for all).

Conclusion:

The increased peak-systolic and end-diastolic velocities of thyroid arteries, and increased
Color Quantification values might be helpful in the diagnosis of Graves’ Disease.
Chemicals Constituents of the Algerian Glycyrrhiza glabra L. Root Extracts and their Antioxidant, Antibacterial and Anticholinesterase Activities
Authors: Barek Saïd , Rahmoun Mohammed N. , Aissaoui Mohammed , Bensouici Chawki , El Haci Imad A. , Hassaine Ridha , Choukchou-Braham Noureddine
Published: January 2020

Background:

Glycyrrhiza glabra L. is an important medicinal plant endowed with various pharmacological virtues. This study aimed to investigate the antioxidant, antibacterial, and anticholinesterase activities of the Algerian Glycyrrhiza glabra L. roots extracts.

Methods:

The chemical composition of both chloroformic (LCh) and ethyl acetate (LAE) extracts were analyzed by RP-HPLC-PDA and 1H NMR spectroscopy. The antioxidant activity was evaluated using hydrogen atoms transfer methods (DPPH) and single electron transfer (ABTS and CUPRAC assays). The antibacterial activity was realized against different strains via the Minimal Inhibitory Concentration (MIC), when the anticholinesterase activity was performed through the acetylcholinesterase and butyrylcholinesterase enzymes inhibition.

Results:

The chemical analysis revealed the presence of phenolic acids (gallic acid, p-coumaric acid) and a hydroxycinnamic compound (ferulic acid). However, flavonoids were represented by quercetin, rutin (flavonol), and glabridin (isoflavane). The 1H NMR of the L4 fraction from LCh extract allowed to characterize the structure of glabridin.

The antioxidant assays revealed that LCh extract is the best among other extracts with IC50DPPH of 33.94 μg/mL, IC50ABTS of 3.45 μg/mL and CUPRAC A0.5of 21.78 μg/mL. The LCh extract displayed an effective antibacterial activity with MIC’s of 19.5 μg/mL against seven gram positive and negative bacteria strains. The same extract showed a potent butyrylcholinesterase inhibitory activity with IC50= 4.72 ± 0.72 μg/mL, which is too strong than the standard drug.

Conclusion:

The study demonstrated that G. glabra root extracts had a high antibacterial, and free radical scavenging. It was also able to inhibit cholinesterase enzymes, which confirm the effectiveness of phytoconstituents present in the plant, especially flavonoids.
Furanocoumarin A: A Novel Anticancer Agent on Human Lung Cancer A549 Cells from Fructus liquidambaris
Authors: Fang Hui , Ji Hongmei
Published: January 2020

Background and Purpose:

The fruit of Fructus liquidambaris, which is recently being used for
cancer treatment, has a history to be used as a traditional medicine in China for thousands of years.

Material and Methods:

Ten kg of dried F. liquidambaris was obtained with 70% alcohol-water solution under
reflux for three times. The condensed extract was obtained from petroleum ether, ethyl acetate and N-butyl
alcohol, respectively. Ethyl acetate extract was subjected to silica gel column, Sephadex LH-20, ODS column
chromatography and RP-HPLC column chromatography to yield a new compound (1). The structure was identified
through intensive analysis of NMR and MS spectra. The antitumor mechanism of the furanocoumarin A on
human lung cancer A549 cells was confirmed by detecting the apoptosis-related proteins.

Result:

Furanocoumarin A (1), a novel furanocoumarin constituent was isolated and identified from F. Liquidambaris.
The IC50 value of furanocoumarin A on A549 cell lines was 65.28±5.36µM obtained by the method of
MTT. The compound could induce the apoptosis of A549 cells by inducing 21.5% early apoptosis and 32.4%
late apoptosis at the concentration of 60µmol/L. Western blot analysis indicated that protein expressions of p53,
caspase 3 and Bax increased in a dose-dependent manner between the concentrations from 40 to 80µM. The
protein expression of Bcl-2 decreased the concentration of 60 and 80&3181;M. The ratio of Bcl-2 to Bax was inversely
proportional to the dose concentration.

Conclusion:

Furanocoumarin A could be a novel anticancer agent from herbal medicine.
Flavonolignans: One Step Further in the Broad-Spectrum Approach of Cancer
Authors: Antal Diana S. , Ardelean Florina , Avram Stefana , Pavel Ioana Z. , Danciu Corina , Soica Codruta , Dehelean Cristina
Published: January 2020

Background:

The small chemical class of flavonolignans encompasses unique hybrid molecules with versatile biological activities. Their anticancer effects have received considerable attention, and a large body of supporting evidence has accumulated. Moreover, their ability to interact with proteins involved in drug resistance, and to enhance the effects of conventional chemotherapeutics in decreasing cell viability make them influential partners in addressing cancer.

Objective:

The review provides an outline of the various ways in which flavonolignans advance the combat against cancer. While the main focus falls on flavonolignans from milk thistle, attention is drawn to the yet, underexplored potential of less known flavonolignan subgroups derived from isoflavonoids and aurones.

Methods:

Proceeding from the presentation of natural flavonolignan subtypes and their occurrence, the present work reviews these compounds with regard to their molecular targets in cancer, anti-angiogenetic effects, synergistic efficacy in conjunction with anticancer agents, reversal of drug resistance, and importance in overcoming the side effects of anticancer therapy. Recent advances in the endeavor to improve flavonolignan bioavailability in cancer are also presented.

Conclusions:

Significant progress has been achieved in detailing the molecular mechanisms of silybin and its congeners in experimental models of cancer. The availability of novel formulations with improved bioavailability, and data from phase I clinical trials in cancer patients provide an encouraging basis for more extensive trials aimed at evaluating the benefits of Silybum flavonolignans in cancer management. On the other hand, further research on the antitumor efficacy of iso-flavonolignans and other subtypes of flavonolignans should be pursued.