bluuebunny/crossref_metadata_2025 huggingface dataset:
Atrial Fibrillation Detection Directly from Compressed ECG with the Prior of Measurement Matrix
Authors: Cheng Yunfei , Hu Ying , Hou Mengshu , Pan Tongjie , He Wenwen , Ye Yalan
Published: September 2020

In the wearable health monitoring based on compressed sensing, atrial fibrillation detection directly from the compressed ECG can effectively reduce the time cost of data processing rather than classification after reconstruction. However, the existing methods for atrial fibrillation detection from compressed ECG did not fully benefit from the existing prior information, resulting in unsatisfactory classification performance, especially in some applications that require high compression ratio (CR). In this paper, we propose a deep learning method to detect atrial fibrillation directly from compressed ECG without reconstruction. Specifically, we design a deep network model for one-dimensional ECG signals, and the measurement matrix is used to initialize the first layer of the model so that the proposed model can obtain more prior information which benefits improving the classification performance of atrial fibrillation detection from compressed ECG. The experimental results on the MIT-BIH Atrial Fibrillation Database show that when the CR is 10%, the accuracy and F1 score of the proposed method reach 97.52% and 98.02%, respectively. Compared with the atrial fibrillation detection from original ECG, the corresponding accuracy and F1 score are only reduced by 0.88% and 0.69%. Even at a high CR of 90%, the accuracy and F1 score are still only reduced by 6.77% and 5.31%, respectively. All of the experimental results demonstrate that the proposed method is superior to other existing methods for atrial fibrillation detection from compressed ECG. Therefore, the proposed method is promising for atrial fibrillation detection in wearable health monitoring based on compressed sensing.
An Acylsucrose-Producing Tomato Line Derived from the Wild Species Solanum pimpinellifolium Decreases Fitness of the Whitefly Trialeurodes vaporariorum
Authors: Rodríguez-López María J. , Moriones Enrique , Fernández-Muñoz Rafael
Published: September 2020

A combination of biological control and host plant resistance would be desirable for optimally controlling the greenhouse whitefly, Trialeurodes vaporariorum in tomato crops. Whitefly settlement preference, oviposition, and survivorship were evaluated on ABL 10-4 and ‘Moneymaker’, two nearly-isogenic tomato lines with, and without, whitefly-resistance traits based on type IV leaf glandular trichomes derived from the tomato wild species Solanum pimpinellifolium, respectively. Significantly reduced preference of T. vaporariorum adult whiteflies for ABL 10-4 leaves was observed. Moreover, T. vaporariorum altered its abaxial–adaxial settling performance on leaves of ABL 10-4 plants. A significantly lower tendency to settle on abaxial leaf surface was observed in ABL 10-4 compared to Moneymaker plants. Furthermore, T. vaporariorum deposited fewer eggs and exhibited a significantly reduced egg to adult survivorship in ABL 10-4 than in Moneymaker plants. Therefore, reduced fitness and distorted performance were observed for T. vaporariorum on ABL 10-4 tomato plants supporting that type IV leaf glandular trichomes might protect them from this pest and, indirectly, from the viruses it transmits.
Scent of Jasmine Attracts Alien Invaders and Records on Citizen Science Platforms: Multiple Introductions of the Invasive Lacebug Corythauma ayyari (Drake, 1933) (Heteroptera: Tingidae) in Italy and the Mediterranean Basin
Authors: Mazza Giuseppe , Nerva Luca , Strangi Agostino , Mori Emiliano , Chitarra Walter , Carapezza Attilio , Mei Maurizio , Marianelli Leonardo , Roversi Pio F. , Campanaro Alessandro , Cianferoni Fabio
Published: September 2020

The jasmine lacebug Corythauma ayyari is a pest of cultivated and ornamental plants mainly associated to Jasminum spp. This invasive insect is native to Asia, and it has been recently introduced in several countries, mainly within the Mediterranean basin. Here, we updated the known distribution of this species, including five new Italian regions (Liguria, Tuscany, Latium, Apulia, and Calabria); Salamis Island in Greece, and the Occitanie region in France. Citizen-science data have significantly contributed to the knowledge on species distribution, and the online platform for sharing biodiversity information can represent an effective tool for the early detection. Molecular analyses revealed that the specimens collected in Peninsular Italy and Sicily belong to a unique clade, suggesting the possibility of a single introduction, whereas those from Menton (France) and Calabria (Southern Italy) are separated from the others and probably originate from separated introductions.
Validation of Fiber Breakage in Simple Shear Flow with Direct Fiber Simulation
Authors: Chang Tzu-Chuan , Bechara Senior Abrahán , Celik Hakan , Brands Dave , Yanev Angel , Osswald Tim
Published: September 2020

This study aims to use particle level simulation to simulate the breakage behavior of glass fibers subjected to simple shear flow. Each fiber is represented as a chain of rods that experience hydrodynamic, interaction, and elastic effects. In order to validate the approach of the model, the simulation results were compared to simple shear flow experiments conducted in a Couette Rheometer. The excluded volume force constants and critical fiber breakage curvature were tuned in the simulation to gain a better understanding of the system. Relaxation of the fiber clusters and a failure probability theory were introduced into the model to solve the fiber entanglement and thus, better fit the experimental behavior. The model showed agreement with the prediction on fiber length reduction in both number average length and weight average length. In addition, the simulation had a similar trend of breakage distribution compared to a loop test using glass fibers.
Characterization of Five New Monosporascus Species: Adaptation to Environmental Factors, Pathogenicity to Cucurbits and Sensitivity to Fungicides
Authors: Cavalcante Allinny Luzia Alves , Negreiros Andréia Mitsa Paiva , Tavares Moisés Bento , Barreto Érica dos Santos , Armengol Josep , Sales Júnior Rui
Published: September 2020

In this study, five new recently described Monosporascus species, M. brasiliensis, M. caatinguensis, M. mossoroensis, M. nordestinus, and M. semiaridus, which were found on weeds collected from cucurbit cultivation fields in northeastern Brazil, are characterized regarding mycelial growth at different pH levels and salinity (NaCl) concentrations, their pathogenicity to selected cucurbit species, and their sensitivity to fungicides with different modes of action. Our results reveal great variability among the representative isolates of each Monosporascus spp. All of them showed a wide range of tolerance to different pH levels, and NaCl significantly reduced their in vitro mycelial growth, although no concentration was able to inhibit them completely. In pathogenicity tests, all seedlings of cucurbits evaluated, melon, watermelon, cucumber, and pumpkin, were susceptible to the five Monosporascus spp. in greenhouse experiments using artificial inoculation of roots. Moreover, all Monosporascus spp. were highly susceptible to the fungicides fludioxonil and fluazinam. Our findings provide relevant information about the response of these new Monosporascus spp. to environmental factors, plant genotypes and fungicides.
Zeta Potentials of Magnetite Particles and Alloy 690 Surfaces in Alkaline Solutions
Authors: Lee Ji-Min , Lim Dong-Seok , Jeon Soon-Hyeok , Hur Do Haeng
Published: September 2020

Magnetite particles deposited on the secondary side of a steam generator (SG) can degrade the integrity and performance of pressurized water reactors. Therefore, it is necessary to produce the data of fundamental interfacial electrokinetic properties of magnetite particles and SG tube materials. This study investigated the zeta potentials of magnetite nanoparticles and Alloy 690 surfaces, which were dependent on the pH value, pH agent, and the presence of NaCl. The zeta potentials of the magnetite nanoparticles increased in the negative direction as the pH increased, regardless of the pH agent. At the same pH value, the absolute values of the zeta potentials with different pH agents were: ethanolamine < ammonia < morpholine. In the presence of NaCl, the zeta potentials of the particles further increased negatively. The meaning of the measured zeta potentials was discussed in terms of the dispersion stability and the agglomeration of the particles. Based on the relationship between the zeta potentials of the particles and Alloy 690 surfaces, the magnetite deposition on Alloy 690 was also discussed. Furthermore, the empirical formulas for the pH-dependent zeta potentials of magnetite particles in each alkaline solution were suggested.
Research on the Hydration Properties of C4A3S-CSH2 Cement System at Different Temperatures
Authors: Li Min , Lan Mingzhang , Chen Zhifeng , Wang Jianfeng , Cui Suping , Wang Yali
Published: September 2020

Sulphoaluminate cement has the advantage of low-temperature application performance, but its hydration mechanism at low temperatures is not yet clear. Anhydrous calcium sulfoaluminate (C4A3S) is the main mineral in the composition of sulfoaluminate cement clinkers. In this paper, C4A3S mixed with gypsum (CaSO4∙2H2O) to form a C4A3S-CSH2 cement system; X-ray diffraction (XRD), thermogravimetric analysis (TG-DTG), scanning electron microscopy (SEM) and mercury intrusion analysis (MIP) to clarify the effect of temperatures on the hydration properties of C4A3S-CSH2 cement system. The results showed that hydration of the C4A3S-CSH2 cement system could carry on at low temperatures, even at −15 °C. The main hydration product was ettringite. Low temperatures did not change the types of the hydration products, but the low temperature of 0 °C was more favorable for the formation of ettringite. The early hydration of the C4A3S-CSH2 cement system was inhibited by the decrease in temperature. However, hydration of the cement at 0 °C continued at a high rate after one day. Morphologies of the ettringite for the C4A3S-CSH2 cement system at −15 °C were needle-like structures, while they were of columnar structure at 0 °C. The compressive strength of samples at 0 °C reached 82 MPa, which is significantly higher than that at 20 °C.
Effect of Cold and Warm Rolling on the Particle Distribution and Tensile Properties of Heterogeneous Structured AlN/Al Nanocomposites
Authors: Song Lei , Lu Fenghua , Jin Feng , Nie Jinfeng , Liu Guiliang , Zhao Yonghao
Published: September 2020

Recently, heterogeneous structured metals have attracted extensive interest due to their exciting mechanical properties. In this work, an AlN/Al nanocomposite with heterogeneous distribution of AlN nanoparticles was successfully prepared by a liquid-solid reaction method combined with subsequent extrusion deformation, which behaves an excellent synergy of tensile strength and ductility. In order to further reveal the particle distribution evolution and the tensile property response during further deformation, a series of rolling treatments with different thickness reductions under room temperature and 300 °C was carried out. The results show that the yield strength and tensile strength of the composites increase significantly from 238 MPa, 312 MPa to 312 MPa, 360 MPa after 85% rolling reduction at 300 °C. While the elongation decreased from 15.5% to 9.8%. It is also noticed that the elongation and tensile strength of the nanocomposites increases simultaneously with increasing deformation. It is considered that the aluminum matrix strengthening effect accounts for the strength enhancement. The AlN spatial distribution in the matrix becomes more homogeneous gradually during the rolling, which is supposed to reduce the stress concentration between the particle and matrix and then promote the ductility increase.
Gradient Microstructure Induced by Surface Mechanical Attrition Treatment (SMAT) in Magnesium Studied Using Positron Annihilation Spectroscopy and Complementary Methods
Authors: Skowron Konrad , Dryzek Ewa , Wróbel Mirosław , Nowak Paweł , Marciszko-Wiąckowska Marianna , Le Joncour Léa , François Manuel , Panicaud Benoit , Baczmański Andrzej
Published: September 2020

Surface mechanical attrition treatment (SMAT) was used to generate a gradient microstructure in commercial grade magnesium. Positron annihilation lifetime spectroscopy and variable energy positron beam measurements, as well as microhardness tests, electron backscatter diffraction, X-ray diffraction, and electrochemical corrosion tests, were used to investigate the created subsurface microstructure and its properties. It was found that SMAT causes an increase in dislocation density and grain refinement which results in increased hardness of the subsurface zone. The mean positron lifetime values indicate trapping of positrons in vacancies associated with dislocations and dislocation jogs. The increase of the SMAT duration and the vibration amplitude influences the depth profile of the mean positron lifetime, which reflects the defect concentration profile. Electrochemical measurements revealed that the structure induced by SMAT increases the susceptibility of magnesium to anodic oxidation, leading to the enhanced formation of hydroxide coverage at the surface and, as a consequence, to the decrease in corrosion current. No significant effect of the treatment on the residual stress was found.
Induction Heating in Nanoparticle Impregnated Zeolite
Authors: Morales Irene , Muñoz Marta , Costa Catia S. , Alonso Jose Maria , Silva João Miguel , Multigner Marta , Quijorna Mario , Ribeiro M. Rosário , de la Presa Patricia
Published: September 2020

The ultra-stable Y (H-USY) zeolite is used as catalyst for the conversion of plastic feedstocks into high added value products through catalytic cracking technologies. However, the energy requirements associated with these processes are still high. On the other hand, induction heating by magnetic nanoparticles has been exploited for different applications such as cancer treatment by magnetic hyperthermia, improving of water electrolysis and many other heterogeneous catalytic processes. In this work, the heating efficiency of γ-Fe2O3 nanoparticle impregnated zeolites is investigated in order to determine the potential application of this system in catalytic reactions promoted by acid catalyst centers under inductive heating. The γ-Fe2O3 nanoparticle impregnated zeolite has been investigated by X-ray diffraction, electron microscopy, ammonia temperature program desorption (NH3-TPD), H2 absorption, thermogravimetry and dc and ac-magnetometry. It is observed that the diffusion of the magnetic nanoparticles in the pores of the zeolite is possible due to a combined micro and mesoporous structure and, even when fixed in a solid matrix, they are capable of releasing heat as efficiently as in a colloidal suspension. This opens up the possibility of exploring the application at higher temperatures.
Soft Topological Transformation Groups
Authors: Oguz Gulay
Published: September 2020

The aim of the present study is to introduce the concept of soft topological transformation groups by examining the topological transformation groups, which are the core subject of algebraic topology under the soft approach. Actions of soft topological groups on soft topological spaces are studied, and the category of soft topological transformation groups is constructed. Also, a translation and conjugation of the soft topological groups are described. Finally, the definitions of soft orbit spaces and soft homogeneous spaces are given, and some of the properties of these concepts are examined in detail.
Optimization of PWHT of Simulated HAZ Subzones in P91 Steel with Respect to Hardness and Impact Toughness
Authors: Lojen Gorazd , Vuherer Tomaž
Published: September 2020

Appropriate post weld heat treatment (PWHT) is usually obligatory when creep resistant steels are welded for thermal power plant components that operate at elevated temperatures for 30-40 years. The influence of different PWHTs on the microstructure, hardness, and impact toughness of simulated heat affected zone (HAZ) subzones was studied. Thereby, coarse grained HAZ, two different fine grained HAZ areas, and intercritical HAZ were subjected to 20 different PWHTs at temperatures 740–800 °C and durations 0.5–8 h. It was found that the most commonly recommended PWHT, of 3 h or less at 760 °C, is insufficient with respect to the hardness and impact toughness of coarse grained HAZ. To obtain a Vickers hardness ≤ 265 HV and impact toughness at least equal to the impact toughness of the base metal (192 J) in the coarse grained HAZ, it took 8 h at 740 °C, 4 h at 760 °C, more than 1 h at 780 °C, and 0.5 h and 800 °C. Even after 8 h at 800 °C, mechanical properties were still within the target range. The most recommendable post weld heat treatments at 780 °C for 1.2–2 h or at 760 °C for 3–4 h were identified. All specimens subjected to these treatments exhibited appropriate hardness, impact toughness, and microstructure.
Genome-Assisted Characterization of Lactobacillus fermentum, Weissella cibaria, and Weissella confusa Strains Isolated from Sorghum as Starters for Sourdough Fermentation
Authors: Falasconi Irene , Fontana Alessandra , Patrone Vania , Rebecchi Annalisa , Duserm Garrido Guillermo , Principato Laura , Callegari Maria Luisa , Spigno Giorgia , Morelli Lorenzo
Published: September 2020

Sourdough fermentation of bakery products is a well-established and widespread technique to confer an added value to the resulting food. In recent decades, gluten-free raw materials have gained more attention due to the diffusion of food disorders such as coeliac disease, but, at the same time, they present difficult manipulation and scarce technological properties because of the absence of gluten. For this reason, the present work was aimed at selecting starter cultures for sourdough application that are isolated from fermentation of sorghum flour. Three isolates of Lactobacillus fermentum, Weissella cibaria, and Weissella confusa were selected for the following properties: exopolysaccharide synthesis, acidification, CO2 production, and amylase activity. The investigated phenotypic characteristics were confirmed by genomic analyses, which also highlighted other potentially beneficial features for use in bakery products employment. These strains, together with bakery yeast, were used for bread preparation using sorghum and wheat flour and after 24 h of fermentation the resulting dough was analyzed to assess the improvement of its characteristics. The presence of lactic acid bacteria (LAB) had a great impact on the final dough, and the best preparation, from a rheological point of view, resulted in one made of sorghum and wheat flour with added LAB and bakery yeast, whose resulting characteristics were similar to all wheat flour doughs. The results of this study suggest a potential application of the selected starters in sorghum composite bread and should be validated with data from large-scale pilot tests conducted in industrial bakeries.
Association of Phosphatidylinositol-Specific Phospholipase C with Calcium-Induced Biomineralization in the Coccolithophore Emiliania huxleyi
Authors: Nam Onyou , Suzuki Iwane , Shiraiwa Yoshihiro , Jin EonSeon
Published: September 2020

Biomineralization by calcifying microalgae is a precisely controlled intracellular calcification process that produces delicate calcite scales (or coccoliths) in the coccolithophore Emiliania huxleyi (Haptophycea). Despite its importance in biogeochemical cycles and the marine environment globally, the underlying molecular mechanism of intracellular coccolith formation, which requires calcium, bicarbonate, and coccolith-polysaccharides, remains unclear. In E. huxleyi CCMP 371, we demonstrated that reducing the calcium concentration from 10 (ambient seawater) to 0.1 mM strongly restricted coccolith production, which was then recovered by adding 10 mM calcium, irrespective of inorganic phosphate conditions, indicating that coccolith production could be finely controlled by the calcium supply. Using this strain, we investigated the expression of differentially expressed genes (DEGs) to observe the cellular events induced by changes in calcium concentrations. Intriguingly, DEG analysis revealed that the phosphatidylinositol-specific phospholipase C (PI-PLC) gene was upregulated and coccolith production by cells was blocked by the PI-PLC inhibitor U73122 under conditions closely associated with calcium-induced calcification. These findings imply that PI-PLC plays an important role in the biomineralization process of the coccolithophore E. huxleyi.
Final-Stage Magmatic Record of Paleo-Asian Oceanic Subduction? Insights from Late Permian to Early Triassic Intrusive Rocks in the Yanbian Area, Easternmost Central Asian Orogenic Belt
Authors: Zhang Chao , Neubauer Franz , Liu Zheng-Hong , Cui Fang-Hua , Guan Qing-Bin
Published: September 2020

This paper reports new zircon LA–ICP–MS U–Pb and Hf isotope data, and whole-rock major and trace element data for Late Permian to Early Triassic intrusive rocks in the Yanbian area, NE China. These data provide new insights into the timing of the final subduction of the Paleo-Asian Ocean beneath the North China Craton. The zircon U–Pb age data indicate that a suite of Late Permian to Early Triassic intrusive rocks related to subduction is present within the Yanbian area. The Late Permian intrusive rocks consist of diorites while the Early Triassic granites and hornblende gabbros constitute a geochemically bimodal igneous rock association. Furthermore, the Early Triassic granites show the geochemical characteristics of shoshonitic rocks. All the rocks are characterized by enrichment in LILEs and LREEs, and depletion in HREEs and HFSEs, suggesting they formed in a subduction setting. Zircons from the Early Triassic gabbros have εHf(t) values and TDM2 ages of +7.6 to +10.7 and 735–1022 Ma, respectively, suggesting that they formed from a primary magma generated by the partial melting of lithospheric mantle material that had been previously modified by subduction-related fluids. The Late Permian diorites have εHf(t) values and TDM2 ages of +0.5 to +9.5 and 853 to 1669 Ma, respectively, while they have high contents of Al2O3, Fe2O3, and low contents of SiO2, Cr, and Ni, indicating Late Permian diorites should derive from the mantle and are influenced by some crustal material. Early Triassic granitic rocks have a wide range of εHf(t) values and TDM2 ages of −4.8 to +9.4 and 852 to 2136 Ma, respectively. Their zircons imply that the Early Triassic granites could be mainly derived from partial melting of the crust, with minor contribution of the crustal material of an ancient crust. The Early Triassic bimodal intrusive rocks in Yanbian area, combined with the regional geologic information; therefore, record a final post-subduction extensional environment due to the break-off of the previously subducted slab.
Non-Coding RNAs: Strategy for Viruses’ Offensive
Authors: Gallo Alessia , Bulati Matteo , Miceli Vitale , Amodio Nicola , Conaldi Pier Giulio
Published: September 2020

The awareness of viruses as a constant threat for human public health is a matter of fact and in this resides the need of understanding the mechanisms they use to trick the host. Viral non-coding RNAs are gaining much value and interest for the potential impact played in host gene regulation, acting as fine tuners of host cellular defense mechanisms. The implicit importance of v-ncRNAs resides first in the limited genomes size of viruses carrying only strictly necessary genomic sequences. The other crucial and appealing characteristic of v-ncRNAs is the non-immunogenicity, making them the perfect expedient to be used in the never-ending virus-host war. In this review, we wish to examine how DNA and RNA viruses have evolved a common strategy and which the crucial host pathways are targeted through v-ncRNAs in order to grant and facilitate their life cycle.
ω-3 and ω-6 Polyunsaturated Fatty Acids, Obesity and Cancer
Authors: D’Angelo Stefania , Motti Maria Letizia , Meccariello Rosaria
Published: September 2020

Recently, nutraceutical bioactive compounds in foods have been discovered for their potential health benefits regarding the prevention of chronic disorders, such as cancer, and inflammatory, cardiovascular, and metabolic diseases. Dietary omega-3 polyunsaturated fatty acids (ω-3PUFAs), including alpha-linolenic acid, docosapentaenoic acid, and eicosapentaenoic acid, are mostly attractive. They are available for the customers worldwide from commonly used foods and/or as components of commercial food supplements. The anti-inflammatory and hypotriglyceridemic effects of these fatty acids are well known, whereas pro-inflammatory properties have been recognized in their dietary counterparts, the ω-6PUFAs. Both ω-3 and ω-6PUFAs contribute to the production of lipid mediators such as endocannabinoids that are notably involved in control of food intake, energy sensing, and food–related disorders. In this review, we present ω-3 and ω-6PUFAs and their derivatives, endocannabinoids; discuss the anti-obesity effects of ω-3PUFAs; their roles in inflammation and colorectal cancer development; and how their action can be co-preventative and co-therapeutic.
Effects of Nutrition/Diet on Brown Adipose Tissue in Humans: A Systematic Review and Meta-Analysis
Authors: Heenan Kelsey A. , Carrillo Andres E. , Fulton Jacob L. , Ryan Edward J. , Edsall Jason R. , Rigopoulos Dimitrios , Markofski Melissa M. , Flouris Andreas D. , Dinas Petros C.
Published: September 2020

Background: Brown adipose tissue (BAT) provides a minor contribution to diet-induced thermogenesis (DIT)—the metabolic response to food consumption. Increased BAT activity is generally considered beneficial for mammalian metabolism and has been associated with favorable health outcomes. The aim of the current systematic review was to explore whether nutritional factors and/or diet affect human BAT activity. Methods: We searched PubMed Central, Embase and Cochrane Library (trials) to conduct this systematic review (PROSPERO protocol: CRD42018082323). Results: We included 24 eligible papers that studied a total of 2785 participants. We found no mean differences in standardized uptake value of BAT following a single meal or after 6 weeks of L-Arginine supplementation. Resting energy expenditure (REE), however, was increased following a single meal and after supplementation of capsinoid and catechin when compared to a control condition (Z = 2.41, p = 0.02; mean difference = 102.47 (95% CI = 19.28–185.67)). Conclusions: Human BAT activity was not significantly affected by nutrition/diet. Moreover, REE was only increased in response to a single meal, but it is unlikely that this was due to increased BAT activity. BAT activity assessments in response to the chronic effect of food should be considered along with other factors such as body composition and/or environmental temperature.
Comparison between Percutaneous Gastrostomy and Self-Expandable Metal Stent Insertion for the Treatment of Malignant Esophageal Obstruction, after Propensity Score Matching
Authors: Song Joo Hye , Ko Jaehyun , Min Yang Won , Kim Kyunga , Lee Hyuk , Min Byung-Hoon , Lee Jun Haeng , Rhee Poong-Lyul , Kim Jae J.
Published: September 2020

Background: The outcomes of the two procedures; self-expandable metal stent (SEMS) insertion and percutaneous gastrostomy (PG) feeding procedures, used in patients with malignant esophageal obstruction, are still controversial. We aimed to compare the outcomes between the two procedures, following propensity score (PS) matching. Methods: We retrospectively reviewed 568 esophageal cancer patients who underwent SEMS insertion (stent group) or PG (gastrostomy group) at the Samsung Medical Center between January 1996 and December 2018. Procedures for reasons other than malignant obstruction were excluded. We analyzed the datasets after PS matching. Primary outcomes were the post-procedural nutritional status, and need for additional intervention (AI). The secondary outcome was overall survival (OS). Results: In a matched cohort, the gastrostomy group showed less decrease in albumin level after the procedure (−0.15 ± 0.57 vs. stent group; 0.41 ± 0.59, p = 0.021). The gastrostomy group required less need for, and number of, AIs (2.1% vs. stent group; 23.4%, p < 0.001 and 0.04 ± 0.25 vs. stent group; 0.31 ± 0.61, p < 0.001). After matching, there was no significant difference between the two groups in OS. However, PG was associated with OS based on multivariable analysis of the matched cohort (vs. stent group, hazard ratio 0.69, 95% confidence interval 0.5–0.95). Conclusions: PG tends to provide better post-procedure nutritional status than SEMS insertion in patients with malignant esophageal obstruction.
Effects of Different n6/n3 PUFAs Dietary Ratio on Cardiac Diabetic Neuropathy
Authors: Urlić Marjan , Urlić Ivanka , Urlić Hrvoje , Mašek Tomislav , Benzon Benjamin , Vitlov Uljević Marija , Vukojević Katarina , Filipović Natalija
Published: September 2020

We studied the influence of experimentally induced DM1, in combination with different dietary n6:n3 polyunsaturated fatty acid (PUFA) ratios on different types of nerve fibers in rat myocardium, in order to reveal whether protective/unfavorable effects of different PUFAs on myocardial function in diabetic patients could be a (partial) repercussion of their effect on the changes in cardiac innervation. The control group (c) and diabetic group (stz) were fed with an n6/n3 ratio of ≈7; the diet of the stz+n6 group had an n6/n3 ratio ≈60, while the diet for the stz+DHA group contained 2.5% of fish oil (containing 16% eicosapentaenoic acid—EPA and 19% docosahexaenoic acid—DHA), n6/n3 ratio of ≈1. DM1 was induced by i.p. injection of streptozotocin (55 mg/kg) and rats were euthanized 30 days after induction. Immunohistochemistry was used for the detection and quantification of different types of neuronal fibers in the cardiac septum. We found changes in cardiac innervations characteristics for the initial phase of experimental DM1, which manifested as an increase in total number and area density of all neuronal fibers, measured by Pgp9.5 immunoreactivity. By detailed analysis, we found that this increase consisted mostly of heavy myelinated NF200 immunoreactive fibers and TH immunoreactive sympathetic fibers, while the density of ChAT immunoreactive parasympathetic fibers decreased. In the deep (middle) part of the myocardium, where rare fibers (of all studied types) were found, significant differences were not found. Surprisingly, we found a more consistent protective effect of n6 PUFAs, in comparison to n3 PUFAs supplementation. These results may provide a better understanding of the potential impacts of different PUFA ratios in the diet of diabetic patients on cardiac innervation and genesis and outcome of diabetic autonomic cardiomyopathy.
Obesity Worsens Gulf War Illness Symptom Persistence Pathology by Linking Altered Gut Microbiome Species to Long-Term Gastrointestinal, Hepatic, and Neuronal Inflammation in a Mouse Model
Authors: Bose Dipro , Saha Punnag , Mondal Ayan , Fanelli Brian , Seth Ratanesh K. , Janulewicz Patricia , Sullivan Kimberly , Lasley Stephen , Horner Ronnie , Colwell Rita R. , Shetty Ashok K , Klimas Nancy , Chatterjee Saurabh
Published: September 2020

Persistence of Gulf War illness (GWI) pathology among deployed veterans is a clinical challenge even after almost three decades. Recent studies show a higher prevalence of obesity and metabolic disturbances among Gulf War veterans primarily due to the existence of post-traumatic stress disorder (PTSD), chronic fatigue, sedentary lifestyle, and consumption of a high-carbohydrate/high-fat diet. We test the hypothesis that obesity from a Western-style diet alters host gut microbial species and worsens gastrointestinal and neuroinflammatory symptom persistence. We used a 5 month Western diet feeding in mice that received prior Gulf War (GW) chemical exposure to mimic the home phase obese phenotype of the deployed GW veterans. The host microbial profile in the Western diet-fed GWI mice showed a significant decrease in butyrogenic and immune health-restoring bacteria. The altered microbiome was associated with increased levels of IL6 in the serum, Claudin-2, IL6, and IL1β in the distal intestine with concurrent inflammatory lesions in the liver and hyperinsulinemia. Microbial dysbiosis was also associated with frontal cortex levels of increased IL6 and IL1β, activated microglia, decreased levels of brain derived neurotrophic factor (BDNF), and higher accumulation of phosphorylated Tau, an indicator of neuroinflammation-led increased risk of cognitive deficiencies. Mechanistically, serum from Western diet-fed mice with GWI significantly increased microglial activation in transformed microglial cells, increased tyrosyl radicals, and secreted IL6. Collectively, the results suggest that an existing obese phenotype in GWI worsens persistent gastrointestinal and neuronal inflammation, which may contribute to poor outcomes in restoring cognitive function and resolving fatigue, leading to the deterioration of quality of life.
Creatine Supply Attenuates Ischemia-Reperfusion Injury in Lung Transplantation in Rats
Authors: Almeida Francine M. , Battochio Angela S. , Napoli João P. , Alves Katiusa A. , Balbin Grace S. , Oliveira-Junior Manoel , Moriya Henrique T. , Pego-Fernandes Paulo M. , Vieira Rodolfo P. , Pazetti Rogerio
Published: September 2020

Ischemia-reperfusion injury (IRI) is one of the factors limiting the success of lung transplantation (LTx). IRI increases death risk after transplantation through innate immune system activation and inflammation induction. Some studies have shown that creatine (Cr) protects tissues from ischemic damage by its antioxidant action. We evaluated the effects of Cr supplementation on IRI after unilateral LTx in rats. Sixty-four rats were divided into four groups: water + 90 min of ischemia; Cr + 90 min of ischemia; water + 180 min of ischemia; and Cr + 180 min of ischemia. Donor animals received oral Cr supplementation (0.5 g/kg/day) or vehicle (water) for five days prior to LTx. The left lung was exposed to cold ischemia for 90 or 180 min, followed by reperfusion for 2 h. We evaluated the ventilatory mechanics and inflammatory responses of the graft. Cr-treated animals showed a significant decrease in exhaled nitric oxide levels and inflammatory cells in blood, bronchoalveolar lavage fluid and lung tissue. Moreover, edema, cell proliferation and apoptosis in lung parenchyma were reduced in Cr groups. Finally, TLR-4, IL-6 and CINC-1 levels were lower in Cr-treated animals. We concluded that Cr caused a significant decrease in the majority of inflammation parameters evaluated and had a protective effect on the IRI after LTx in rats.
Use of End-of-Class Quizzes to Promote Pharmacy Student Self-Reflection, Motivate Students to Improve Study Habits, and to Improve Performance on Summative Examinations
Authors: Vinall Ruth , Kreys Eugene
Published: September 2020

Underperforming students are often unaware of deficiencies requiring improvement until after poor performance on summative exams. The goal of the current study was to determine whether inclusion of individual end-of-class formative quizzes, which comprise of higher level Bloom’s questions, could encourage students to reflect on and address deficiencies and improve academic performance. Ninety-seven out of 123 first-year pharmacy students (79%) enrolled in a Biochemistry and Cell & Molecular Biology course participated in a single-blinded, randomized, controlled, crossover study. Paired t-test analyses demonstrated that that implementation of individual end-of-class formative quizzes resulted in significantly higher summative exam scores for below average students (p = 0.029). Notably, inclusion of quizzes significantly improved performance on higher Bloom’s questions for these students (p = 0.006). Analysis of surveys completed by students prior to summative exam indicate that the formative end-of-class quizzes helped students identify deficiencies (89%) and making them feel compelled to study more (83%) and attend review sessions (61%). Many students indicated that quizzes increased stress levels (45%). Our collective data indicate that quizzes can improve summative exam performance for below average first year pharmacy students, and improve self-reflection and student motivation to study. However, the impact on student stress levels should be considered.
Theodicy, Undeserved Suffering, and Compassionate Solidarity: An Interdisciplinary Reading of Hwang Sok-Yong’s The Guest
Authors: Kim Young Hoon
Published: September 2020

The author explores theological questions regarding the Korean novelist Hwang Sok-yong’s The Guest from interdisciplinary perspectives. This paper analyzes the novel in relation to the emotional complex of han as understood in Korean minjung theology, the political theology of Johann Baptist Metz, and Ignacio Ellacuría’s liberation theology. Drawing upon the perspectives of Korean, German, and Latin American scholars, this approach invites us to construct a discourse of theodicy in a fresh light, to reach a deeper level of theodical engagement with the universal problem of suffering, and to nurture the courage of hope for human beings in today’s stressed world. Contemplating the concrete depiction of human suffering in The Guest, the paper invites readers to deepen their understanding of God in terms of minjung theology’s thrust of resolving the painful feelings of han of the oppressed, Metz’s insight of suffering unto God as a sacramental encounter with God, and Ellacuría’s idea of giving witness to God’s power of the resurrection in eschatological hope. The paper concludes that the immensity of today’s human suffering asks for that compassionate solidarity with the crucified today which can generate hope in the contemporary milieu.
Teaching Controversial Issues in Diverse Religious Education Classrooms
Authors: Flensner Karin K.
Published: September 2020

In educational contexts, certain issues are perceived as controversial, since they reflect conflicts of interest and reveal divergent views. This is especially evident in debates related to religion in societies regarding themselves as secular but whose population is multi-religious. The aim of this article is to analyse how some issues that are considered controversial in the public debate are represented in the teaching of non-denominational and integrative Religious Education in a Swedish multicultural classroom practice, where the majority of students have a Muslim cultural background. The ethnographic empirical material consists of classroom observations of Religious Education lessons in upper secondary school. The analysis is based on the debate about how controversial issues ought to be taught—as empirically or politically open/settled or in a directive/non-directive way. The results indicate that a number of issues—divergent interpretations of religious narratives and religiously motivated rules, holidays, views of forgiveness, the Israeli–Palestinian conflict and abortion—were regarded as open political issues in classroom practice and these were taught in an open, non-directive way. Issues represented as settled were value-oriented issues related to female genital mutilation, forced marriage and child marriage and gender equality. The arguments supporting these values were mainly rooted in religion.
C-Band Dual-Doppler Retrievals in Complex Terrain: Improving the Knowledge of Severe Storm Dynamics in Catalonia
Authors: del Moral Anna , Weckwerth Tammy M. , Rigo Tomeu , Bell Michael M. , Llasat María Carmen
Published: September 2020

Convective activity in Catalonia (northeastern Spain) mainly occurs during summer and autumn, with severe weather occurring 33 days per year on average. In some cases, the storms have unexpected propagation characteristics, likely due to a combination of the complex topography and the thunderstorms’ propagation mechanisms. Partly due to the local nature of the events, numerical weather prediction models are not able to accurately nowcast the complex mesoscale mechanisms (i.e., local influence of topography). This directly impacts the retrieved position and motion of the storms, and consequently, the likely associated storm severity. Although a successful warning system based on lightning and radar observations has been developed, there remains a lack of knowledge of storm dynamics that could lead to forecast improvements. The present study explores the capabilities of the radar network at the Meteorological Service of Catalonia to retrieve dual-Doppler wind fields to study the dynamics of Catalan thunderstorms. A severe thunderstorm that splits and a tornado-producing supercell that is channeled through a valley are used to demonstrate the capabilities of an advanced open source technique that retrieves dynamical variables from C-band operational radars in complex terrain. For the first time in the Iberian Peninsula, complete 3D storm-relative winds are obtained, providing information about the internal dynamics of the storms. This aids in the analyses of the interaction between different storm cells within a system and/or the interaction of the cells with the local topography.
Regression Analysis of Subsidence in the Como Basin (Northern Italy): New Insights on Natural and Anthropic Drivers from InSAR Data
Authors: Nappo Nicoletta , Ferrario Maria Francesca , Livio Franz , Michetti Alessandro Maria
Published: September 2020

Natural and anthropogenic subsidence such as that in the Como urban area (northern Italy) can cause significant damage to structures and infrastructure, and expose the city’s lakefront to an increasing risk of inundation from Lake Como. This phenomenon affecting the Como basin has been studied by several researchers, and the major drivers of subsidence are known. However, the availability of historical InSAR data allowed us to reconsider the relationship between subsidence predisposing factors (i.e., the thicknesses of reworked and compressible layers, overburden stress, and the piezometric level) and ground surface displacements with higher precision over the entire basin. Benefiting from the deep knowledge of the hydromechanical setting of the Como basin and the availability of InSAR measurements from 1992 to 2010, in this paper we model subsidence-related movements using linear and nonlinear regression methods in order to determine the combination of natural and anthropic factors that have caused subsidence in the Como basin over the past decades. The results of this study highlight peculiar patterns of subsidence that suggest the influence of two further causes, namely tectonic control of the sedimentary architecture and diversion of local streams, which have never been considered before. This analysis aims to assess the spatial distribution of subsidence through InSAR analysis in order to enhance the knowledge and understanding of the phenomenon in the Como urban area. The interferometric data could be used to better plan urban risk management strategies.
Application of Machine Learning to Debris Flow Susceptibility Mapping along the China–Pakistan Karakoram Highway
Authors: Qing Feng , Zhao Yan , Meng Xingmin , Su Xiaojun , Qi Tianjun , Yue Dongxia
Published: September 2020

The China–Pakistan Karakoram Highway is an important land route from China to South Asia and the Middle East via Pakistan. Due to the extremely hazardous geological environment around the highway, landslides, debris flows, collapses, and subsidence are frequent. Among them, debris flows are one of the most serious geological hazards on the Karakoram Highway, and they often cause interruptions to traffic and casualties. Therefore, the development of debris flow susceptibility mapping along the highway can potentially facilitate its safe operation. In this study, we used remote sensing, GIS, and machine learning techniques to map debris flow susceptibility along the Karakoram Highway in areas where observation data are scarce and difficult to obtain by field survey. First, the distribution of 544 catchments which are prone to debris flow were identified through visual interpretation of remote sensing images. The factors influencing debris flow susceptibility were then analyzed, and a total of 17 parameters related to geomorphology, soil materials, and triggering conditions were selected. Model training was based on multiple common machine learning methods, including Ensemble Methods, Gaussian Processes, Generalized Linear models, Navies Bayes, Nearest Neighbors, Support Vector Machines, Trees, Discriminant Analysis, and eXtreme Gradient Boosting. Support Vector Classification (SVC) was chosen as the final model after evaluation; its accuracy (ACC) was 0.91, and the area under the ROC curve (AUC) was 0.96. Among the factors involved in SVC, the Melton Ratio (MR) was the most important, followed by drainage density (DD), Hypsometric Integral (HI), and average slope (AS), indicating that geomorphic conditions play an important role in predicting debris flow susceptibility in the study area. SVC was used to map debris flow susceptibility in the study area, and the results will potentially facilitate the safe operation of the highway.
Mapping Tea Plantations from VHR Images Using OBIA and Convolutional Neural Networks
Authors: Tang Zixia , Li Mengmeng , Wang Xiaoqin
Published: September 2020

Tea is an important economic plant, which is widely cultivated in many countries, particularly in China. Accurately mapping tea plantations is crucial in the operations, management, and supervision of the growth and development of the tea industry. We propose an object-based convolutional neural network (CNN) to extract tea plantations from very high resolution remote sensing images. Image segmentation was performed to obtain image objects, while a fine-tuned CNN model was used to extract deep image features. We conducted feature selection based on the Gini index to reduce the dimensionality of deep features, and the selected features were then used for classifying tea objects via a random forest. The proposed method was first applied to Google Earth images and then transferred to GF-2 satellite images. We compared the proposed classification with existing methods: Object-based classification using random forest, Mask R-CNN, and object-based CNN without fine-tuning. The results show the proposed method achieved a higher classification accuracy than other methods and produced smaller over- and under-classification geometric errors than Mask R-CNN in terms of shape integrity and boundary consistency. The proposed approach, trained using Google Earth images, achieved comparable results when transferring to the classification of tea objects from GF-2 images. We conclude that the proposed method is effective for mapping tea plantations using very high-resolution remote sensing images even with limited training samples and has huge potential for mapping tea plantations in large areas.