bluuebunny/crossref_metadata_2025 huggingface dataset:
РЕТРОСПЕКТИВНИЙ ДИСКУРС СИСТЕМНОГО ВИМІРУ ПОЛІТИКИ ЄВРОПЕЙСЬКОГО СОЮЗУ
Authors: Марчук Наталія
Published: October 2024

Складовими ретроспективного дискурсу системного виміру політики Європейського Союзу вибрано, з одного боку, процеси, що впливають на розбудову політичної системи ЄС, з іншого – шлях еволюції політичних систем держав – членів Європейського Союзу, об’єднаних не лише сучасною географією, але й спільними кордонами різних держав і міждержавних союзів у минулому. Встановлено, що історичними етапами розвитку політичних систем країн ЄС є: середньовіччя та феодальна система з децентралізованими політичними системами та обмеженими правами населення; абсолютизм і централізація влади з домінуванням централізованих монархій; початок демократичних змін з поступовим інституціональним обмеженням монархічної влади й зародженням ідей Просвітництва; революції і становлення парламентських систем з падінням абсолютних монархій, зростаючою роллю виборних органів і перших конституцій; розвиток національних держав і демократії із введенням загального виборчого права; тоталітарні режими та їх падіння – період, який охопив дві світові війни, появу й подальше падіння тоталітарних режимів, відновлення демократичних систем; європейська інтеграція і поширення демократії; розширення ЄС і консолідація демократичних принципів; етап сучасних викликів XXI ст. Акцентовано вплив створення Європейського Союзу на політичні системи його країн-членів, зокрема щодо зміцнення демократії та верховенства права, гармонізації законодавства, підвищення ролі парламентів і громадянського суспільства, політичної інтеграції та спільних політик, зміцнення незалежності судової влади, поширення європейських цінностей тощо. Аргументовано, що Європейський парламент є найбільш стабільною складовою політичної системи ЄС. Попри нашарування криз і соціально-економічних викликів протягом кожного електорального періоду, інституція продовжує виконувати покладені на неї функції, масштабуючи вплив на важливі напрямки політики ЄС та життя його громадян. Актуалізовано необхідність вивчення можливостей запозичення досвіду ефективної парламентської діяльності для України.
РОЛЬ ОРГАНІВ ВЛАДИ І ГРОМАДСЬКИХ ІНСТИТУЦІЙ В СИСТЕМІ ОРГАНІЗАЦІЇ СОЦІАЛЬНОЇ БЕЗПЕКИ В УМОВАХ ВОЄННОГО СТАНУ
Authors: Березовська-Чміль Олена , Ковальчук Ігор
Published: October 2024

У статті з’ясовано суть поняття «соціальна безпека», його розвиток і затвердження в науковій сфері. Узагальнено погляди науковців на суть цього поняття й особливості соціальної безпеки на державному та регіональному рівнях. Розглянуто роль органів державної влади та місцевого самоврядування, політичних і громадських інституцій у системі забезпечення соціальної безпеки в умовах воєнного стану. Доведено, що війна має руйнівний вплив і наслідки на всі сфери життєдіяльності людини, зокрема соціальну, і тому перед Україною як державою стоїть важливе завдання перешкодити негативному впливу і в умовах дестабілізувальних процесів, які несе війна, забезпечити на належному рівні соціальну безпеку своїх громадян. Автори дійшли висновку, що проблема забезпечення соціальної безпеки в умовах повномасштабного вторгнення РФ на територію України є надзвичайно важливою та потребує першочергової уваги. Безпека життя й діяльності людини є основою держави та її інституцій. Метою статті є визначення й аналіз ролі органів влади та громадських інституцій у системі організації соціальної безпеки в умовах воєнного стану.
ТРАКТУВАННЯ ПОЛЯКАМИ УКРАЇНСЬКИХ МІГРАНТІВ (2022–2024 РР.)
Authors: Богачик-Дідович Юлія
Published: October 2024

Стаття покликана проаналізувати ставлення до українських вимушено переселених осіб серед польського суспільства. Стверджується, що після повномасштабного вторгнення Росії в Україну значна кількість українців мігрувала до Республіки Польща з надією знайти безпеку. Зазначається, що в 2022–2023 роках Польща сформувала сприятливе законодавство для українського переселенця, надаючи додатковий податковий статус PESEL UKR. Наголошується, що попри позитивне сприяння уряду для підтримки українських біженців, усе ж у польському суспільстві проявлялися кризові явища, які перетворювалися на економічні й політичні конфлікти. Останнім таким прикладом став зерновий конфлікт. В умовах російської агресії проти України такі конфліктні явища призвели до значних економічних наслідків і порушення національного інтересу. У відповідь на це українському уряду потрібно інтенсифікувати публічну дипломатію в Польщі з метою нівеляції негативних явищ і протидії російській пропаганді, яка значно посилилася серед польського суспільства.
ТЕОРЕТИКО-МЕТОДИЧНІ АСПЕКТИ ФОРМУВАННЯ БІОЕНЕРГЕТИЧНОГО ПОТЕНЦІАЛУ
Authors: Фурман І.В. , Ксенчин Д.О.
Published: October 2024

Досліджено підходи до теоретико-методичних аспектів оцінки біоенергетичного потенціалу різних авторів. Досліджено методичні підходи дооцінки біоенергетичного потенціалу з точку зору економічної ефективності та екологічних факторів. Досліджено методики окремих авторів що враховують комплекс факторів орієнтований на оцінку еколого-економічної ефективності біопалив. Проведений аналіз доцільності розвитку державно-приватного партнерства в біоенергетичній сфері. Визначено, що розвиток виробництва біопалив вимагає значних інвестиційних ресурсів, а в умовах військового стану державне стимулювання не може забезпечити належної підтримки тому доцільним є розвиток механізмів державно-приватного партнерства. Обґрунтовано, шо розвиток біоенергетичного потенціалу України можливий лише за умови активної державної підтримки. Визначено, що фінансова допомога, податкові пільги та сприятливе законодавство – це ключові елементи, які залучать інвестиції та пришвидшать розвиток галузі. Розроблена універсальна методика оцінки біоенергетичного потенціалу, що дозволить оцінити потенціал розвитку біоенергетики в конкретному регіоні, розробити оптимальні стратегії використання біомаси та приймати обґрунтовані рішення щодо інвестицій у біоенергетичні проекти.
Algorithm Decision Tree in Analysis Social Media Sentiment to Understand Consumer Views of Brands
Authors: Pramana Gusman Aggy , Andrianof Harkamsyah
Published: October 2024

Online marketplaces in Indonesia are growing rapidly and have become one of the main destinations for internet and social media users. Various marketplace services are available and accessed by the majority of Indonesians. However, with this development, consumer satisfaction with marketplace services varies, from positive, to negative, to neutral. Many consumers express their reactions on social media, including Twitter. In this study, an analysis of opinions was conducted on posts by online business customers in Indonesia on Twitter from various consumers. However, due to the large number of comments, it is difficult to conclude the customer's opinion about online shopping sites that offer the best services. Even trending topics on Twitter only display hot topics that are widely discussed without clear conclusions. To classify general opinion data on Twitter from e-commerce sites, the first step is to process tweet data using Rapidminer tools to recognize the tweet data. Then, the decision tree algorithm is used to categorize opinion data. The results showed that using cross-validation, the decision tree algorithm achieved an accuracy of 70.27 percent while using split validation, it achieved an accuracy of 66.95 percent. In this case, better accuracy was achieved using cross-validation. The results of this study can provide useful information for online businesses in Indonesia to improve the quality of their services and increase customer satisfaction. In addition, this study also provides an overview of the importance of utilizing the decision tree algorithm in categorizing opinion data on social media, especially on Twitter, as a tool for analyzing consumer sentiment towards a service or product.
Implementasi IDS dan IPS terhadap Serangan TCP Port Scanning dan ICMP Flooding
Authors: Razzanda Iqbal Maqdum , Muhammad Koprawi
Published: October 2024

The implementation of Intrusion Detection System (IDS) and Intrusion Prevention System (IPS) is a crucial step in maintaining network security. This research aims to test the effectiveness of IDS and IPS in detecting and preventing TCP port scanning attacks and ICMP flooding attacks and also providing real-time notifications using Telegram. The methodology used includes configuring a test environment that reflects real network scenarios, where various attacks are initiated to test the IDS and IPS responses. The experimental results show that IDS is able to detect suspicious activity with a high degree of accuracy, while IPS is effective in blocking identified attacks, thereby reducing potential damage to the system. Proper implementation of IDS and IPS can significantly improve network security by early detecting and preventing cyberattacks.
Usability Evaluation and Alternative Design Recommendations for HSIS Mobile Application: A Case Study of PT HNI
Authors: Rozanah  , Harry Budi Santoso
Published: October 2024

Halal Network International (HNI) is considered as one of the sharia MLM-based companies in Indonesia. In order to fulfill the sales management needs, HNI developed HSIS application. The aims of this study are to conduct usability testing and to design alternative interface design recommendations for the HSIS Mobile application by using the User-centered Design (UCD) process. This study applied the System Usability Scale (SUS) Questionnaire, Open-ended Question (OEQ), and Task Scenario within Usability Testing (UT) as research instruments. There were 81 respondents involved in filling out the questionnaires. Furthermore, UT Phase 1 was conducted by involving 14 respondents. The results of these processes were categorized, and the design solutions were mapped based on Nielsen's Ten Usability Heuristic of Interface Design and Shneiderman's Eight Golden Rules of Interface Design. The alternative design solutions were tested again in UT Phase 2 and they showed a significant decrease in the number of usability issues. Thus, it proves that the alternatives design can provide positive improvement in the usability and user experience of the HSIS Mobile application.
Penerapan Algoritma Convolutional Neural Network Untuk Klasifikasi Penyakit Kanker Kulit
Authors: Septhya Dhini , Rahmaddeni  , Susanti  , Agustin
Published: October 2024

Kulit merupakan organ penting yang melindungi tubuh manusia, sehingga perawatan sejak dini sangat penting untuk mencegah penyakit seperti kanker kulit. Kanker kulit adalah penyakit serius yang dapat berakibat fatal dan membutuhkan biaya pengobatan tinggi. Penyakit ini menduduki urutan ketiga setelah kanker serviks dan kanker payudara di Indonesia, dengan faktor penyebab meliputi genetik dan paparan radiasi sinar UV. Deteksi dini dan diagnosis tepat sangat penting untuk meningkatkan peluang kesembuhan, sehingga klasifikasi kanker kulit diperlukan untuk menghindari penundaan penanganan. Metode Deep Learning, khususnya Convolutional Neural Network (CNN), telah terbukti memberikan hasil signifikan dalam klasifikasi citra dengan akurasi tinggi. VGG16 dan DenseNet121 adalah dua arsitektur CNN yang populer digunakan dalam klasifikasi citra. Penelitian ini bertujuan untuk membandingkan performa klasifikasi kanker kulit menggunakan VGG16 dan DenseNet121. Hasil penelitian menunjukkan bahwa arsitektur DenseNet121 memberikan akurasi lebih tinggi dibandingkan dengan arsitektur VGG16, dengan akurasi 93% untuk data train dan 79% untuk data test, sedangkan arsitektur VGG16 mencapai akurasi 80% untuk data train dan 74% untuk data test. Hasil ini menunjukkan bahwa arsitektur DenseNet121 lebih unggul dalam klasifikasi kanker kulit, memberikan informasi penting untuk diagnosis yang lebih akurat.
ANALISIS PERBANDINGAN PERFORMA FHRP PADA ROUTING EIGRP MENGGUNAKAN IPV4 DAN IPV6
Authors: Wahyudi Sandi , Destya Senie
Published: October 2024

Terbatasnya kapasitas IPv4 yang hanya mendukung sekitar 4,3 miliar alamat unik mendesak pengembangan sistem pengalamatan yang lebih besar. IPv6 dikembangkan untuk mengatasi keterbatasan ini, menyediakan alamat yang  lebih luas serta membawa perbaikan dalam manajemen alamat dan keamanan. Pada jaringan yang andal dan efisien, penting untuk menanggulangi kegagalan dan error yang dapat menurunkan Quality of Service (QoS). QoS memastikan jaringan yang memerlukan keandalan, bandwidth tinggi, atau latensi rendah dapat berfungsi optimal. Salah satu metode untuk mengatasi kegagalan jaringan adalah menggunakan First Hop Redundancy Protocol (FHRP), seperti HSRP (Hot Standby Router Protocol) dan GLBP (Gateway Load Balancing Protocol). Penelitian ini menunjukkan bahwa GLBP pada IPv6 memberikan performa jaringan terbaik dibandingkan protokol lainnya. GLBP pada IPv6 mencapai throughput tertinggi sebesar 93.95130523 Bytes dan delay terendah sebesar 1.000519298 detik dalam kondisi normal. Selain itu, pada kondisi gangguan, GLBP pada IPv6 memiliki downtime terendah sebesar 3.7 detik dan packet loss paling rendah sebesar 0,1%.
Comparison of Machine Learning Algorithms for Face Classification Using FaceNet Embeddings
Authors: Catoer Ryando  , Riyanto Sigit  , Setiawardhana  , Bima Sena Bayu Dewantara
Published: October 2024

In recent years, face recognition has grown significantly in importance and popularity. Google created FaceNet, a deep learning system, in 2015, and it performs very well in creating extremely precise and personalised numerical representations of faces, or embeddings. In order to swiftly and effectively identify people, this study evaluates FaceNet's effectiveness in producing face embeddings and applies it to a variety of classification techniques, including support vector machine (SVM), decision tree, random forest, and k-nearest neighbours (KNN). A dataset with a wide range of positions, facial expressions, and lighting settings is used for the assessment. The findings of the experiment demonstrated that SVM with an radial basis function (RBF) kernel outperformed the other assessed classification techniques, achieving the maximum accuracy of 95%. These findings demonstrate the wide range of applications that face recognition technology may be used for, including identity management and security in different settings.
Analysis on Heterostructure Band Diagram Designs and Electrical Characteristics of Light Emitting Diode (LED)
Authors: Lin Khin Ohmar , Aye Maung , Hla Tin Tin
Published: October 2024

This paper presents the analysis on hetero-structure band diagram designs and electrical characteristics of light emitting diode (LED). This work is based on physical parameters of ZnCdSe, a ternary alloy semiconductor composed of Zinc (Zn), Cadmium (Cd), and Selenium (Se). In this work, the band diagram design results for n-ZnCdSe/p-Si heterojunction leds are approved by the parameters of the material such as such as effective masses of the materials, doing concentrations, electron and hole hall mobilities, bandgap bowing and so on. The electrical characteristics (energy dispersion with wave vector, intrinsic carrier concentration with temperature, intensity with wavelengths) of LED based on ZnCdSe material are also analyzed in this paper. This simulation curves are done by computer simulation. The band layer design for n-ZnCdSe/p-Si LED confirmed the high quality LED for real applications. This research gives information for the researchers who study in electronic and optoelectronic semiconductor devices.
Du rideau de fer au réseau écologique. Géopolitique et conservation de la nature aux frontières de l’Europe du Nord
Authors: Florin Ian
Published: October 2024

La signature en 2010 du mémorandum sur la Ceinture verte de Fennoscandie acte la volonté de la Finlande, de la Norvège et de la Russie de constituer un réseau écologique le long de leurs frontières communes. Par cet accord, les trois pays s’engagent à faire de la nature laissée intacte par les restrictions d’accès durant la Guerre froide un objet de dialogue entre l’Europe du Nord et la Russie. Basé sur une recherche documentaire et sur près de septante entretiens, cet ouvrage se propose d’étudier le développement de la Ceinture verte de Fennoscandie au prisme de la géographie politique. L’auteur met en lumière l’articulation entre conservation de l’environnement et géopolitique depuis la fin de la Guerre froide, les propositions concurrentes dont le concept de réseau écologique peut être porteur et les difficultés à impliquer les populations locales dans des initiatives de conservation de l’environnement. À l’heure où les relations russo-européennes sont gelées par la guerre en Ukraine et où l’importance des réseaux écologiques est confirmée par la Stratégie mondiale de conservation de la biodiversité, ce livre offre un éclairage original sur des enjeux d’une actualité brûlante.
Shaping Society for Tomorrow: The Role of Higher Education in Bringing About Positive Change
Authors: Evans Carolyn
Published: October 2024

While universities must be responsive to the complex times in which we live and to the increasing demands of governments and others, they also need to work towards a future beyond the next electoral or economic cycle. This requires a deep understanding of their core mission and values. This chapter argues that we need to recognise the benefits of diversity, and to consider higher education (HE) as an ecosystem rather than trying to force all universities into similar patterns. It discusses the importance of universities being permeable and looking outward to create positive social and environmental impact. This chapter uses Griffith University’s Research Beacons as a key example of how inter- and transdisciplinary collaboration can directly address community needs to create a better future for all.
Grain yield predictor model using agronomic aspects and vegetative indices of soybean
Authors: Zuse Guilherme Hickembick , Carvalho Ivan Ricardo , Fillipin Gustavo Henrique , Conceição Gerusa Massuquini , Silva José Antonio Gonzalez , Pradebon Leonardo Cesar , Bruinsma Gabriel Mathias Weimer , Porazzi Felipe Uhde , Pettenon Adriano
Published: October 2024

The objective of this work was to evaluate, through a predictive model, which factors influence soybean yield, using agronomic aspects and vegetative indices, in addition to identifying the best soybean cultivar for the northwest of Rio Grande do Sul. The experimental design used was strips with randomized blocks, consisting of 10 cultivars and five blocks. Analyzing the quantitative characters, the positive contributions to yield came from the grain weight of vegetables with two grains, and the grain weight of the plant, having a strong influence on the average grain yield. The vegetable grain weight with three grains contributed negatively to the yield, as the average grain weight was lower than expected, lowering the average grain yield. For the vegetation indices that contributed positively, the GRAY, IGB and RGRI index stand out, while the BGI, GLI2, GRAY2, IGR, IRB, NRBDI and NG indices had negative contributions to the average grain yield. The NEO 581 E cultivar showed better yield performance, reaching 5780 kg ha⁻1, followed by the SOYTECH 541 I2X cultivar, which reached a yield of 5356 kg ha⁻1. The predictive model identified the main variables that influenced final yield, with Cercospora sojina and Corynespora casiicola, grain weight in three-grain legumes, plant grain weight, GRAY index, IGB, NGBDI and RGRI, the variables that contributed positively to grain yield.
Pathogenesis and inflammaging in myelodysplastic syndrome
Authors: Villaume Matthew T , Savona Michael R
Published: October 2024

Myelodysplastic syndromes (MDS) are a genetically complex and phenotypically diverse set of clonal hematologic neoplasms that occur with increasing frequency with age. MDS has long been associated with systemic inflammatory conditions and disordered inflammatory signaling is implicated in MDS pathogenesis. A rise in sterile inflammation occurs with ageing and the term “inflammaging” has been coined by to describe this phenomenon. This distinct form of sterile inflammation has an unknown role in in the pathogenesis of myeloid malignancies despite shared correlations with age and ageing-related diseases. More recent is a discovery that many cases of MDS arise from clonal hematopoiesis of indeterminate potential (CHIP), an age associated, asymptomatic pre-disease state. The interrelationship between ageing, inflammation and clonal CHIP is complex and likely bidirectional with causality between inflammaging and CHIP potentially instrumental to understanding MDS pathogenesis. Here we review the concept of inflammaging and MDS pathogenesis and explore their causal relationship by introducing a novel framing mechanism of “pre-clonal inflammaging” and “clonal inflammaging”. We aim to harmonize research on ageing, inflammation and MDS pathogenesis by contextualizing the current understanding of inflammaging and the ageing hematopoietic system with what is known about the etiology of MDS via its progression from CHIP.
IMPLEMENTASI STRATEGI PAIKEM DALAM MENINGKATKAN MOTIVASI BELAJAR SISYA DI PASRAMAN SAMIAGA
Authors: Sintia Ni Kadek
Published: October 2024

Artikel ini bertujuan untuk menganalisis implementasi strategi Pembelajaran, Aktif, Inovatif, Kreatif, Efektif, dan Menyenangkan (PAIKEM) dalam meningkatkan motivasi belajar sisya di Pasraman Samiaga. Pasraman merupakan lembaga pendidikan Hindu yang memiliki peran krusial dalam mewujudkan generasi muda yang bermoral dan berintelektual. Namun pembelajaran yang monoton, sistem pembelajaran kelas rangkap, kurangnya penggunaan teknologi, dan kesenjangan antara materi yang dibutuhkan dan diterima merupakan beberapa hal yang mempengaruhi motivasi belajar sisya. Sebagai salah satu upaya acarya di Pasraman Samiaga yaitu mengimplementasikan strategi PAIKEM. Penelitian ini menggunakan pendekatan kualitatif dengan metode pengumpulan data melalui observasi langsung non partisipan, wawancara langsung tidak terstruktur, dan studi dokumentasi. Analisis data dalam penelitian ini, dilakukan melalui reduksi data, penyajian data, dan penarikan kesimpulan. hasil Hasil analisis data menunjukan bahwa implementasi strategi Pembelajaran Aktif, Inovatif, Kreatif, Efektif, dan Menyenangkan (PAIKEM) di Pasraman Samiaga dapat meningkatkan motivasi belajar sisya. Hal ini terlihat dari peningkatan semangat belajar, sisya tidak merasa tertekan atau tegang, sisya terdorong untuk aktif dan tidak bosan, sisya termotivasi untuk lebih giat belajar, sisya bertanya kepada guru atau teman ketika ada materi yang belum dimen, menyadari pentingnya belajar, dan percaya bahwa usaha yang dilakukan tidak akan menghianati hasil.
 
Keywords: Strategi, PAIKEM, Motivasi Belajar, Pasraman
ANALISIS KESIAPAN GURU DALAM IMPLEMENTASI KURIKULUM MERDEKA BELAJAR DI SD NEGERI TAUBNENO
Authors: Lakapu Pifa A , Lasmawan I Wayan , Suastra I Wayan
Published: October 2024

The independent learning curriculum is a new policy initiated by the government as one of the first steps in supporting the realization of national education goals, namely to make the nation's life smarter through liberating education. Teachers play an important role in both curriculum development and implementation. The aim of this research is to determine the readiness of Inpres Taubneno Elementary School teachers to implement the independent learning curriculum at Inpres Taubneno Elementary School. This type of research method is a qualitative-descriptive research method. The subjects in this research were teachers from grades 1 to IV and the principal of SD Inpres Taubneno. Data collection techniques in this research included interviews and documentation. This research shows that the teachers at SD Inpres Taubneno are ready to implement the independent learning curriculum. The teachers were prepared by attending offline workshops held at the school. Teacher preparation has not been optimal because they are still waiting for workshops to be held at schools for training in preparing teaching tools, but the independent learning curriculum has been implemented. The independent learning curriculum is implemented in stages so that the independent learning curriculum has been implemented in grades I and IV. The implementation of the independent learning curriculum at Inpres Taubneno Elementary School is known as the independent learning curriculum. From the results of this research, it can be concluded that the teachers at SD Inpres Taubneno are ready to implement the independent learning curriculum at school. However, the preparation of teachers at Inpres Taubneno Elementary School has not been optimal because Inpres Taubneno Elementary School teachers are still in the preparation stage.
Comparative Analysis of Transcription Factors TWIST2, GATA3, and HES5 in Glioblastoma Multiforme : Evaluating Biomarker Potential and Therapeutic Targets Using in Silico Methods
Authors: Chung Suhmi , Kim Choonghyo
Published: October 2024

Objective : Glioblastoma multiforme (GBM) is characterized by substantial heterogeneity and limited therapeutic options. As molecular approaches to central nervous system tumors have gained prominence, this study examined the roles of three genes, TWIST2, GATA3, and HES5, known to be involved in oncogenesis, developmental processes, and maintenance of cancer stem cell properties, which have not yet been extensively studied in GBM. This study is the first to present gene expression data for TWIST2, GATA3, and HES5 specifically within the context of GBM patient survival.Methods : Gene expression data for TWIST2, GATA3, and HES5 were collected from GBM and normal brain tissues using datasets from The Cancer Genome Atlas via the Genomic Data Commons portal and the Genotype-Tissue Expression database. These data were rigorously analyzed using in silico methods.Results : All three genes were significantly more expressed in GBM tissues than in normal tissues. TWIST2 and GATA3 were linked to lower survival rates in GBM patients. Interestingly, higher HES5 levels were associated with better survival rates, suggesting a complex role that needs more investigation.Conclusion : This study shows that TWIST2, GATA3, and HES5 could help predict outcomes in GBM patients. Our multigene model offers a better understanding of GBM and points to new treatment options, bringing hope for improved therapies and patient outcomes. This research advances our knowledge of GBM and highlights the potential of molecular diagnostics in oncology.
Estrategias de marketing y captación de pacientes en clínicas dentales: Desarrollo e implementación de campañas de marketing digital para atraer nuevos pacientes y efectividad de las redes sociales como herramienta de marketing para clínicas dentales
Authors: Piedra Andrade Melissa Nicole , Astudillo Pablo Andrés , Bravo Manolo Esteban , Cordero Coronel María Isabel , Bravo Calderón Manuel Estuardo
Published: October 2024

Objetivo: Este estudio busca analizar cómo las estrategias de marketing digital impactan la captación y fidelización de pacientes en clínicas dentales, considerando la evolución de la competencia en el sector. Metodología: Se realizó una exhaustiva revisión bibliográfica de artículos científicos sobre estrategias y prácticas exitosas en marketing dental. Resultados: Los hallazgos destacan que la optimización de sitios web, el uso de SEO y Google Ads aumentan la visibilidad de las clínicas. Las redes sociales emergen como herramientas clave, facilitando la interacción con pacientes actuales y potenciales. La personalización y segmentación del marketing permiten crear mensajes relevantes, incrementando la conversión de prospectos en pacientes leales. La gestión de la reputación en línea también se identifica como un factor crítico en la decisión de los pacientes. Conclusión: El marketing digital ha transformado las estrategias de captación en clínicas dentales. Al identificar y segmentar adecuadamente al público objetivo, personalizar las comunicaciones y utilizar herramientas digitales avanzadas, las clínicas pueden destacarse en un mercado competitivo, logrando así una mayor captación y fidelización de pacientes.
Analysis of unsteady tip leakage flow in an axial compressor rotor using dynamic mode decomposition
Authors: Wei Xindi , Tang Yumeng , Hou Jiexuan , Liu Yangwei
Published: October 2024

Tip leakage flow (TLF) is an important flow structure in the compressor, and it has a significant effect on the efficiency and stability of the compressor. In this study, dynamic mode decomposition (DMD) is used to study the spatiotemporal flow structure of the tip leakage flow in a compressor rotor. The high-fidelity flow field calculated via the delayed-detached eddy simulation (DDES) of an axial compressor rotor is used as the input dataset for the DMD algorithm. The results show that the unsteady motion of the tip leakage vortex (TLV) is quite different at its generation, development, and dissipation phases. Additionally, three typical unsteady structures, the oscillation of the primary TLV, the TLV breakdown, and the unsteadiness of the unsteady blockage cell, is identified by the DMD modes. Unsteady motions also largely affect the vortex structure and loss generation, especially after the vortex breakdown. The spatiotemporal structure identified by DMD provides a new understanding, which could be helpful for the modeling or flow control of the TLF.
Equivalence of Contour Integrals to Residues Multiplied by Winding Numbers in Complex Analysis
Authors: CHEN WEN-XIANG
Published: October 2024

In complex analysis, the evaluation of contour integrals is fundamentally linked to the concepts of residues and winding numbers. This paper provides a comprehensive proof demonstrating the equivalence of contour integrals to the product of residues and winding numbers. Additionally, it elucidates how residues and winding numbers can be expressed in terms of derivatives of specific functions, highlighting their intrinsic connections to function behavior around singularities. Furthermore, the paper extends these foundational concepts to more complex scenarios involving higher-order poles, essential singularities, multi-dimensional contours, and applications in advanced fields such as quantum mechanics and electrical engineering. The exploration includes intricate mathematical derivations, generalizations, and the interplay between topology and complex analysis, thereby enriching the theoretical framework of complex integration.
Identifikasi Kadar Hidrokunon Pada Krim Pemutih Yang Beredar Di Marketplace
Authors: Nasiroh Nasiroh , Rahmadani Rahmadani , Salwati Salwati , Alawiyah Tuti
Published: October 2024

Latar belakang: Penggunaan produk kosmetik khususnya krim pemutih wajah yang mengandung hidrokuinon dapat berisiko terhadap kesehatan Masyarakat yang menggunakannya karena dapat menyebabkan kanker (bersifat karsinogenik) dan gangguan pada kulit seperti ochronosis (warna kulit menjadi kehitaman). Akan tetapi, pada kasus di lapangan seringkali ditemukan masih adanya kandungan hidrokuinon di dalam sebuah sediaan kosmetik yang beredar. Oleh karena itu perlu dilakukan penelitian lebih lanjut mengenai kandungan hidrokuinon dalam sediaan kosmetik.
Tujuan: Untuk mengetahui kandungan dan kadar hidrokuinon pada sampel sediaan krim pemutih.
Metode: Penelitian ini menggunakan jenis observasional analitik. Pengujian dilakukan menggunakan alat Kromatografi Cair Kinerja Tinggi (KCKT). Analisis kualitatif dilakukan dengan pengamatan waktu retensi, sedangkan analisis kuantitatif dilihat dari luas area atau konsentrasi yang kemudian dihitung untuk mendapatkan kadar hidrokuinon.
Hasil: Hasil penelitian krim pemutih wajah yang beredar di marketplace Shopee, Tokopedia, dan Bukalapak mengandung hidrokuinon pada tiga sampel dengan kadar yang terkandung pada sampel 1 sebesar 0,002204%, sampel 4 sebesar 0,03%, dan sampel 5 sebesar 0,137%.
Kesimpulan: Krim pemutih wajah yang beredar di marketplace Shopee, Tokopedia, dan Bukalapak terdapat kandungan hidrokuinon pada sampel yang diteliti.
Health Education Influences Mother's Knowledge in Preventing Stunting in Infants
Authors: Sitorus Sony Bernike Magdalena , Sasmita Hanum , Lailatul K. Marlina Fitriya
Published: October 2024

Introduction: The 2022 SSGI results indicate that the prevalence of stunting in Indonesia has decreased from 24.4% to 21.6% compared to the previous year. The target to be achieved by 2024 is to reduce the prevalence of stunting to 14%. Efforts to reduce the incidence of stunting include conducting health promotions about stunting. Purpose: This research aims to analyze the effect of health education on mothers' knowledge about stunting prevention in toddlers in the Malei Health Center working area, Poso Regency. Method: This quasi-experimental study employed a pre-experiment research design with a one-group pretest-posttest approach. The research was conducted in July 2023 in the working area of the Malei Health Center, Lage District, Poso Regency. The sample size was 65 people, selected through simple random sampling. Result: Univariate analysis showed that the majority of respondents were aged 20–35 years (53.9%), had education levels ranging from elementary to junior high school (58.5%), and were unemployed (72.3%). The Wilcoxon test was used for bivariate analysis due to the non-normal distribution of the data. Statistical test results showed a significant increase in respondents' knowledge, with an average score increase of 50.2 and a p-value <0.05. Conclusion: Health education significantly influences maternal knowledge of stunting prevention. It is recommended that health promotion efforts be enhanced through education about stunting.
The impact of access to climate services on smallholder farmers' cropping decisions and household food security in Elundini municipality, Eastern Cape province
Authors: Nocezo Yanga-Inkosi , Manyike Jabulile Zamokuhle , Zhou Leocadia , Ngarava Saul
Published: October 2024

The study assesses how access to climate services influences cropping decisions and, subsequently, household food security. Employing a cross-sectional research design, the study surveyed a total of 217 smallholder crop farmers selected through a multistage sampling approach. Data were collected using a semi-structured questionnaire, and both descriptive statistics and a propensity score matching (PSM) model were employed for data analysis. Household food security was assessed using households' dietary diversity. The study's findings highlight that 69% of the surveyed farmers had access to weather forecasts, while only 24% had access to seasonal forecasts. Consequently, farmers with access to climate services exhibited changes in their farming decisions, including daily farming activities, planting timing, crop selection, and land preparation. Notably, approximately 35% of the respondents were identified as food insecure. The application of the propensity score matching model revealed that access to climate services had a statistically significant positive impact on farmers' decision-making processes and household food security. These results underscore the potential of climate services to enhance farmers' decision-making capabilities and, subsequently, improve household food security. Considering these findings, it is recommended that efforts to expand access to climate services among smallholder farmers in South Africa should be intensified. This can be achieved by developing and disseminating more accessible and tailored climate information, including seasonal forecasts. In addition, initiatives should ensure that climate services are integrated into agricultural extension services and support systems to equip farmers with the knowledge and tools they need to make informed decisions.
Embracing innovation and advancing care: integrating learning health system principles into Inova Schar Heart and Vascular
Authors: O’Connor Christopher M. , Rosner Carolyn M. , Gill Andrew , Speir Alan M. , Neville Richard F.
Published: October 2024

Inova Schar Heart and Vascular has an unwavering commitment to delivering excellent cardiovascular care and has integrated principles of a learning health care system to develop our system of continuous process improvement and innovation. A learning health system integrates its internal experiences with external research to enhance patient outcomes, support the discovery of new treatments and care pathways, and deliver safer, more efficient, and more personalized care. Leveraging learning across health systems maximizes the impact, allowing cardiovascular teams to gain insights into the effectiveness of different treatment strategies. In this Frontiers in Cardiovascular Medicine compendium of articles, the team at Inova describe the spectrum of research and educational activities that have contributed to our progress as a learning cardiovascular health system and support our journey to deliver excellent cardiovascular care.
Does dance therapy benefit the improvement of blood pressure and blood lipid in patients with hypertension? A systematic review and meta-analysis
Authors: Wang Jialin , Yin Yikun , Yu Zhengze , Lin Qihan , Liu Yongsheng
Published: October 2024

Objective

Hypertension is a risk factor of cardiovascular disease. Dance, a type of aerobic exercise, is beneficial as a therapy in reducing blood pressure. This study aimed to systematically review the therapeutic effectiveness of dance therapy (DT) on blood pressure and blood lipid of patients with hypertension.

Methods

Searching CNKI, VIP, Wan Fang Databases, CBM, PubMed, EBSCO (MEDLINE), Cochrane Library, and Web of Science to collect randomized controlled trials (RCTs) about dance therapy in the treatment of patients with hypertension according to the inclusion and exclusion criteria, with the search time ranged from the date of database construction to January 2024. The Cochrane risk-of-bias tool and PEDro were used to evaluate the risk of included trials. The meta-analysis was implemented by using RevMan 5.4 and Stata 12.0 software.

Results

A total of 983 patients were included in 11 randomized controlled trials. According to the meta-analysis, compared with the control group, Dance Therapy effectively reduced systolic blood pressure (SBP) [MD = −7.45, 95% CI (−8.50, −6.39), p < 0.0001] and diastolic blood pressure (DBP) [MD = −2.95, 95% CI (−3.78, −2.13), p < 0.0001], and it increased high-density lipoprotein cholesterol (HDL-C) [MD = 0.20, 95% CI (−0.02, 0.42), p < 0.0001]. The subgroup analysis results showed that the treatment efficacy was more excellent with the frequency more than 3 times per week, the cycle less than 12 weeks, and the duration less than 60 min every time.

Conclusion

The results indicates that SBP, DBP, and HDL-C in hypertensive patients have been effectively improved after dance therapy intervention. In addition, it is recommended to implement dance therapy for hypertensive patients with a treatment cycle of 12 weeks, and treat at least 3 times a week, with each treatment duration controlled within 60 min.

Systematic Review Registration

[http://www.crd.york.ac.uk/PROSPERO], identifier [CRD42024500807].
Role of standard echocardiography in Anderson–Fabry disease
Authors: Conte Maddalena , Cioffi Giuseppe , Romeo Maria Grazia , Petraglia Laura , Parente Erika , Poggio Paolo , Myasoedova Veronika , Russo Vincenzo , Lauro Raffaella , Accardo Roberta , Leosco Dario , Parisi Valentina
Published: October 2024

Cardiac involvement strongly impacts prognosis in patients with Anderson–Fabry disease (AFD). All cardiac structures, such as the left ventricle and the left atrium, the aorta, the right sections, and the heart valves can be affected by morphological and functional abnormalities. Standard echocardiography has a crucial role in the characterization of AFD cardiomyopathy. Being a diffuse, non-invasive, easily reproducible, and inexpensive investigation, echocardiography represents the most appropriate tool for screening AFD cardiomyopathy. Furthermore, echocardiographic evaluation is the essential imaging method to support the physician also in the follow-up and risk stratification of AFD patients. Therefore, echocardiography is useful in all stages of the disease, both to reveal the first signs of cardiac involvement and to guarantee timely treatment in the preclinical stage and to estimate the extent of cardiac involvement, define possible complications, and evaluate the response to treatment in patients with established cardiomyopathy. The latest advanced echocardiographic techniques, such as speckle-tracking analysis, are offering new insights into the early detection of AFD cardiac involvement, thus suggesting a promising role for echocardiography in selecting appropriate candidates for treatment. In this review, we will examine the role of standard echocardiography in AFD, focusing on its use in screening for cardiac involvement, detailed characterization of AFD cardiomyopathy, and risk stratification of AFD patients.
Promoting fairness in link prediction with graph enhancement
Authors: Liu Yezi , Chen Hanning , Imani Mohsen
Published: October 2024

Link prediction is a crucial task in network analysis, but it has been shown to be prone to biased predictions, particularly when links are unfairly predicted between nodes from different sensitive groups. In this paper, we study the fair link prediction problem, which aims to ensure that the predicted link probability is independent of the sensitive attributes of the connected nodes. Existing methods typically incorporate debiasing techniques within graph embeddings to mitigate this issue. However, training on large real-world graphs is already challenging, and adding fairness constraints can further complicate the process. To overcome this challenge, we propose FairLink, a method that learns a fairness-enhanced graph to bypass the need for debiasing during the link predictor's training. FairLink maintains link prediction accuracy by ensuring that the enhanced graph follows a training trajectory similar to that of the original input graph. Meanwhile, it enhances fairness by minimizing the absolute difference in link probabilities between node pairs within the same sensitive group and those between node pairs from different sensitive groups. Our extensive experiments on multiple large-scale graphs demonstrate that FairLink not only promotes fairness but also often achieves link prediction accuracy comparable to baseline methods. Most importantly, the enhanced graph exhibits strong generalizability across different GNN architectures. FairLink is highly scalable, making it suitable for deployment in real-world large-scale graphs, where maintaining both fairness and accuracy is critical.
The influence of mobile-assisted critical writing instructions on EFL learners' writing skill in language institutes
Authors: Zalani Mahdi , Weisi Hiwa , Yousofi Nouroddin
Published: October 2024

This study examined the influence of mobile-assisted critical writing instructions on EFL learners' writing skill in language institutes. Ninety EFL learners who were studying English at three branches of a language institute in Iran took part in this research. Two equal groups as control and experimental were formed. As the pretest, a writing task was assigned to the groups which required them to write an argumentative report. The reports were the participants' personal analyses of the contents they had viewed on TV about an important political issue. After the pretest, the control group received instructions for critical writing in class without using Instagram. The treatment lasted for 12 weeks. During the treatment, the control group were asked to watch some TV channels devoted to news. The experimental group received instructions for critical writing in class and via Instagram. The treatment lasted for 12 weeks. The experimental group, who were all Instagram users, were asked to view some Instagram accounts belonging to famous news agencies. Additionally, an Instagram account was created by the teacher and they were asked to follow it for receiving instructions there. When the treatments ended, the posttest was administered. The control group were required to watch the TV channels and the experimental group were required to view the Instagram accounts to write an argumentative report about an important political issue. The reports were the participants' personal analyses of the contents they had viewed. Despite having nearly the same mean scores on the pretest, the two groups' mean scores on the posttest were different and the experimental group scored higher than the control group. Finally, 15 members of the experimental group were interviewed. The focus of the interview was on the participants' suggestions and criticisms of the study. Overall, the experimental group had positive perceptions of the treatment. This study may have implications for teacher trainers, supervisors, teachers, and textbook writers.
Pediatric acute-onset neuropsychiatric syndrome and pediatric autoimmune neuropsychiatric disorder associated with streptococcal infections: a delphi study and consensus document about definition, diagnostic criteria, treatment and follow-up
Authors: Grandinetti Roberto , Mussi Nicole , Pilloni Simone , Ramundo Greta , Miniaci Angela , Turco Emanuela , Piccolo Benedetta , Capra Maria Elena , Forestiero Roberta , Laudisio Serena , Boscarino Giovanni , Pedretti Laura , Menoni Martina , Pellino Giuditta , Tagliani Silvia , Bergomi Andrea , Antodaro Francesco , Cantù Maria Cristina , Bersini Maria Teresa , Mari Sandra , Mazzini Franco , Biasucci Giacomo , Suppiej Agnese , Esposito Susanna
Published: October 2024

Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal Infections (PANDAS) and Pediatric Acute-onset Neuropsychiatric Syndrome (PANS) are broad diagnoses that encompass a range of sudden-onset neuropsychiatric symptoms in children, which can include obsessive-compulsive disorder (OCD), tics, anxiety, emotional instability, and cognitive difficulties. Unlike PANDAS, PANS is not strictly linked to group A streptococcal infections but can be triggered by various infectious or environmental factors. Lights and shadows remain upon the management of children with PANS and PANDAS and there is no clear consensus regarding definition, diagnostic criteria, treatment, and follow-up. The aim of the present study was to evaluate the level of agreement on PANS and PANDAS definition, diagnostic criteria, treatment and follow-up and to assess on the basis of recent studies whether there is a need to modify the current recommendations used by primary care pediatricians and hospital pediatricians in clinical practice in order to improve outcomes. Using the Delphi method, this consensus provides shared indications on PANS and PANDAS management in pediatric age, based on the most updated literature. This work represents, in our opinion, the most complete and up-to-date information on the diagnosis of PANS and PANDAS, as well as consensus statements about several aspects of clinical care. Undoubtedly, more randomized and controlled trials are needed in the pediatric population to better define the best management, also in terms of adequate follow-up examinations and period of observation.
Targeting TGFβ with chimeric switch receptor and secreted trap to improve T cells anti-tumor activity
Authors: Matikhina Tatyana , Cohen Cyrille J.
Published: October 2024

Introduction

TGFβ is a major immunoinhibitory factor present in the microenvironment of solid tumors. Various cancer types acquire the ability to overexpress TGFβ to escape immune response. Specifically, TGFβ dampens cytotoxic T cell activity, and its presence has been correlated with tumor invasion and poor prognosis.

Methods

In this study, we developed two approaches to counteract the effects of TGFβ and provide a functional advantage to genetically engineered T cells in the immunoinhibitory tumor milieu. We designed a TGFβRI-based co-stimulatory switch receptor (CSRI), comprising the TGFβ receptor I extracellular binding domain and a 4-1BB co-stimulatory signaling moiety. Additionally, we tested the efficacy of a TGFβ-binding scFv trap produced by T cells.

Results

We demonstrated that both approaches enhanced tumor-specific T cell cytokine secretion, upregulated activation markers, and reduced inhibition markers upon co-culture with melanoma targets. Furthermore, CSRI and the anti-TGFβ trap exhibited improved anti-tumor function in vivo.

Conclusion

Overall, we show that targeting the TGFβ pathway can enhance cellular immunotherapy.