bluuebunny/crossref_metadata_2025 huggingface dataset:
Who is the ‘Guardian of the Sea’? A Narrative Practice Approach Analysis of a Short Story Book for Six to Eight Years Old on the Main Character's Environmental Identity Construction
Authors: Chatzifotiou Athanasia
Published: January 2023

This project used a story book for young readers (aged 6–8) to explore environmental identity features and their potential impact upon its young readers. A variety of different units of analysis from the narrative practice approach were employed to explore: a) how the story's narrative constructs the environmental identity of the main character; b) what kind of environmental identity it promotes and c) whether reading a story can be considered a ‘proxy’ of a ‘formative’ childhood experience in relation to the environment.

The analysis showed a gradual construction of the main character's environmental identity; moving from passivity and ignorance to agency and knowledge. However, the notion of agency was rather limited to an individualistic agency that can potentially empower young readers to act on a local level without helping them to see environmental issues in a wider societal context.

Finally, the idea of reading an environmental story as a ‘formative’ experience is discussed in relation to the aforementioned findings and to literature relevant within sustainability education pedagogies.
Reflections of Good Practice of Infusing ESD to Improve Education Outcomes for Indigenous Learners in Light of a Global Pandemic
Authors: Kohl Katrin , Hopkins Charles
Published: January 2023

The COVID-19 global pandemic presented an unprecedented challenge to the sustainability strategies and initiatives of many nations. In many countries, education strategies and funding were negatively impacted and, consequently, especially vulnerable groups were highly affected, amongst them Indigenous communities around the world. As Indigenous communities were already amongst the most vulnerable before 2020, a strategically and well-planned recovery from this pandemic would be vital to secure their well-being.

This article offers reflections on the potential of infusing Education for Sustainable Development (ESD) in the classroom, the school and the community as a whole, to deal with known and yet unprecedented sustainability challenges in presenting commonalities of 32 good practice reports from 21 countries collected in advance and during the global pandemic. Authors make the point of considering the pandemic and its widespread impact as yet another sustainability challenge and position ESD as a potential tool to achieve quality education and unleash the full potential of education for society when planning recovery efforts in hope for a better future of Indigenous communities in the long term.

As the good practices were also included in a report of the UN Special Rapporteur on the Rights of Indigenous Peoples to the 48th Session of the United Nations Human Rights Council, focusing on the post-pandemic recovery efforts for Indigenous Peoples, further thoughts on both official reports and their alignment with the overall 2030 Agenda from an ESD perspective are included.
New Wine Needs to Be Put Into New Bottles: Legitimating Education for Sustainability in South Korea's Higher Education Institutions
Authors: Yoo Sung-Sang , Jeon Minjeong
Published: January 2023

The aim of the paper is to critically examine the practices of teaching and learning for the Sustainable Development Goals (SDGs) in the context of higher education institutions (HEIs) in South Korea (Korea). With the use of a case study, this paper offers a close examination of the practices carried out at Seoul National University and Kyung Hee University in Korea, focusing on how the SDGs are embedded in teaching and learning for sustainable development and identifying barriers and challenges in the process. A few specific initiatives and curriculum developments to meet the SDGs have been identified, but their rhetorical visions and practices of teaching and learning contradict, resulting in little actual transformation. This study reveals the gap between the rhetoric and the reality of teaching and learning for the SDGs from the perspective of transformative learning and offers policy suggestions to provide a well-rooted practice of educating the SDGs in Korean HEIs.
A Proximal Policy Optimization Reinforcement Learning Approach to Unmanned Aerial Vehicles Attitude Control
Authors: Bălaşa Răzvan-Ionuț , Bîlu Marian Ciprian , Iordache Cătălin
Published: January 2023

The latest developments in the field of Machine Learning (ML), especially Reinforcement Learning (RL) techniques, reduce the need of having pre-existing data available. In this paper, we are presenting a Reinforcement Learning approach to Unmanned Aerial Vehicles (UAV) trajectory tracking and attitude control for an X configuration quadcopter. The proposed solution aims to tackle different maneuvers and to be able to withstand a wide variety of environmental disturbances, both while ensuring the success of the mission for which the Unmanned Aerial Vehicle has been designed. The Proximal Policy Optimization (PPO) solution has first been trained in a simulation environment. The model of the vehicle is designed to take into account various configurations, including changes of mass, while the model of the environment contains various disturbances sources.
N-acetylcysteine efficacy in patients hospitalized with COVID-19 pneumonia: a systematic review and meta-analysis
Authors: Paraskevas Themistoklis , Kantanis Anastasios , Karalis Iosif , Michailides Christos , Karamouzos Vasileios , Koniari Ioanna , Pierrakos Charalampos , Velissaris Dimitrios
Published: January 2023

Background: N-acetylcysteine (NAC) is a mucolytic agents with anti-inflammatory properties that has been suggested as an adjunctive therapy in patients with COVID-19 pneumonia. Objectives: We conducted a systematic review and meta-analysis to evaluate available evidence on the possible beneficial effects of NAC on SARS-CoV-2 infection.

Methods: In September 2022, we conducted a comprehensive search on Pubmed/Medline and Embase on randomized controlled trials (RCTs) and observational studies on NAC in patients with COVID-19 pneumonia. Study selection, data extraction and risk of bias assessment was performed by two independent authors. RCTs and observational studies were analyzed separately.

Results: We included 3 RCTs and 5 non-randomized studies on the efficacy of NAC in patients with COVID-19, enrolling 315 and 20826 patients respectively. Regarding in-hospital mortality, the summary effect of all RCTs was OR: 0.85 (95% CI: 0.43 to 1.67, I2=0%) and for non-randomized studies OR: 1.02 (95% CI: 0.47 to 2.23, I2=91%). Need for ICU admission was only reported by 1 RCT (OR: 0.86, 95% CI:0.44-1.69, p=0.66), while all included RCTs reported need for invasive ventilation (OR:0.91, 95% CI:0.54 to 1.53, I2=0). Risk of bias was low for all included RCTs, but certainty of evidence was very low for all outcomes due to serious imprecision and indirectness.

Conclusion: The certainty of evidence in the included studies was very low, thus recommendations for clinical practice cannot be yet made. For all hard clinical outcomes point estimates in RCTs are close to the line of no effect, while observational studies have a high degree of heterogeneity with some of them suggesting favorable results in patients receiving NAC. More research is warranted to insure that NAC is both effective and safe in patients with COVID-19 pneumonia.
Government Educational Spending and Human Capital Development in ECOWAS Sub-Region: Implication For Sustainable Development
Authors: Oloke Emmanuel , Olanipekun Wahid Damilola , Mabinuori Oladotun Toriola , Ojo Lucas B. , Aderemi Timothy Ayomitunde
Published: January 2023

The critical need to create economic prosperity and ensure inclusive and equitable education and lifelong learning for all, especially in developing countries has been the motivation behind the various advocacies by the policymakers and other stakeholders in these countries to achieve the SDGs comes 2030. Meanwhile, ECOWAS sub region is characterized with the lowest human capital development alongside the highest rates of illiteracy in the world despite the continuous rise in government educational spending over the years. Against this backdrop, the role of government educational spending on human capital development in ECOWAS sub-region has been investigated with a view to driving one of the strategic goals of Sustainable Development- inclusive and equitable education and lifelong learning for all. In order to achieve this, annual data from 1990 to 2019 was utilized using a panel ARDL as a technique of estimation. The findings that emerged in this work are summarized as follows; the relationship between government educational spending and human capital development in ECOWAS sub region is more of a long run phenomenon. Therefore, government educational spending and human capital development have a positive and significant relationship in the long run. In the light of the above findings, this study therefore makes the following recommendations for the policymakers in ECOWAS sub region and by extension developing countries, any time the goal of these policymakers is inclusive and equitable lifelong learning via human capital development, the government at levels should embark on sustainable educational spending. In the same vein, these policymakers should be committed to funding of educational sector as stipulated by both the United Nations and the Abuja declaration of 2001, advocating for 26% of annual budget for educational sector in developing countries.
Potential of chitosan oligosaccharide gel as a cavity cleanser against adhesive restoration adhesive on the cavity wall
Authors: TARIGAN Madya Theresa , ABIDIN Trimurni
Published: January 2023

Cavity cleanser is a cavity cleaner with ideal properties such as being biocompatible, antibacterial,removing smear layers, and not interfering with the adhesive bond. This study aims to examine the potential of gelchitosan oligosaccharide (COS) as a cavity cleanser on the adhesion of the restoration to the cavity wall. Thirty-twomandibular premolars with class V restorations are divided into two groups with 2% COS gel and 2% chlorhexidinedigluconate (CHX). Samples were immersed in 2% methylene blue, cut longitudinally, observed under astereomicroscope with 1x magnification, and scored 0-3. The Mann-Whitney test was used to see the potential of gelCOS as a cavity cleanser. The results showed a significant difference between the two groups at the edge of theenamel junction restoration (p=0.038) and the dentin junction restoration (p=0.027). The mean microleakage score ingroup 1 showed better results at the enamel junction (1.19± 1.328) and the dentin junction (2.00±1.211). It shows that2% COS gel has the potential as a cavity cleanser. There was a significant difference between the two groups as acavity cleanser on the adhesion of adhesive restorations to the cavity wall.KEYWORDS: cavity cleanser; chitosan oligosaccharide; chlorhexidine digluconate; microleakage
Falsely elevated levels of 25(OH) vitamin D measured on alinity: two case reports
Authors: de Vera Mae Jeraldine , Sierens Ann , Vandevenne Leen
Published: January 2023

Background:

Conventional biochemistry parameters employ the use of photometry and enzymatic reactions which reduce the possibility of analytical errors. On contrary, tests performed with immunoassay are known to be more prone to analytical interferences and may subsequently yield incorrect values.

Case presentation:

We present two cases investigated due to very high levels of vitamin D in the serum that exceeded the measurable limit of the analyzer. Protein electrophoresis showed a monoclonal peak, revealing elevated immunoglobulin G and elevated immunoglobulin M respectively. Gold standard analysis of vitamin D using liquid chromatography-mass spectrometry revealed normal vitamin D concentrations in both cases. Further, bone marrow puncture revealed a diagnosis consistent with multiple myeloma and Waldenströms macroglobulinemia.

Conclusion:

Falsely elevated levels of vitamin D exceeding the maximum measurable limit is highly suspicious. Although analytical interference in immunoassay is limited, we should keep in mind that results obtained by this method are more prone to analytical errors.
Characteristics of the Stone Age of Crimea in the Creative Heritage of A.S. Moiseev.
Authors: Cherkasov Aleksey Vladimirovich , Kozlov Mikhail Nikolaevich
Published: January 2023

The purpose of the article is to characterize the contribution of the Russian scientist Alexander Silovich Moiseev to the archaeological study of the Stone Age of the Mountainous Crimea. To achieve the goal, the following tasks were envisaged: the selection of articles on the primitive archeology of the Crimea from the entire array of scientific publications of the scientist, their subsequent historiographical analysis and generalization. The research methodology was based on the complex application of scientific principles: historicism, objectivity, comparative historical approach, retrospection. The problem field of the research included the following components: establishing continuity in the history of the study of the Stone Age of the Crimean peninsula, formulating priority problems of the primitive archeology of the region in the works of the scientist. The source base for the study was the published articles by A.S. Moiseev on the history of the Stone Age of the Mountainous Crimea. In the course of the conducted research, it was found that during the short-lived but important expeditions of A.S. Moiseev as director of the Natural History Museum in Yalta, the source base was gradually formed in the articles of the scientist and the program of future studies of the ancient history of the peninsula was concretized. A.S. Moiseev put the study of the Stone Age of the Crimea to a qualitatively new level. In particular, he actualized the need to search and excavate primitive monuments with careful fixation of all finds in plan and section, justified the expediency of joint stationary excavations of several well-known archaeological sites with systematic searches in new, not yet explored areas. In addition, the author's innovations are the transition from the simple collection of flints and tools to their systematization and typology, the formation of ordered collections; the creation of a complete archaeological map of primitive sites and locations of the peninsula with their detailed stratigraphy, as well as the strengthening of scientific ties between representatives of regional and academic science in the study of Paleolithic, Mesolithic and Neolithic monuments of the Crimea.
The orthopedic surgery preparatory exam course: Measuring residents’ satisfaction and perceptions through video ethnomethodology and survey analysis
Authors: Batouk Omar , Justinia Taghreed E. , Almutairi Mohammed M. , Omair Aamir
Published: January 2023

Objectives:

Orthopedic training in Saudi Arabia has changed how residents are assessed for their board examination. The new format uses scenario cases instead of real patients during the assessment. However, these changes were not received well by the residents. The Orthopedic Surgery Preparatory Exam Course is a 3-day training course designed specifically to address these concerns. This study investigated the effectiveness, perceptions, and satisfaction levels of the residents who took this course, emphasizing the video recording approach.

Methods:

A quantitative survey was designed by the research team and validated by experts. Edits were made after their feedback. Purposive sampling was used, and all 12 attendees of the course participated. All participants were 5th-year residents enrolled in the orthopedics residency training program in Saudi Arabia. A qualitative ethnomethodology analysis of video recordings for pre- and post-mock exams was also conducted.

Results:

The analysis demonstrated that participants were less anxious in the post-mock exam and showed improvement in their confidence and communication skills based on analysis of the assessed criteria such as eye contact, vocal projection, gestures, posture, and movement. The participants generally perceived the course useful in preparing for their board exam.

Conclusion:

The participants generally perceived the course to be useful in helping them to prepare for their board exam by familiarizing them with the exam environment. The participants reported the strength of the course as being able to provide a realistic simulated experience. On the other hand, the participants viewed the weakness of the course in its duration and generally requested more days to be added to the course. They were generally satisfied with the course helping them prepare for the board exam. It is recommended to incorporate the course as part of the residency training program curriculum.
The Role of Fractal Micro-Pore to Absorption of Methane Gas, Case Study: Coal of Tanjung Formation, Arang Alus Area, Banjar District, South Kalimantan, Indonesia
Authors: Raharjo Sugeng , Rahmad Basuki , Gunawan Ketut , Prayitno Budi
Published: January 2023

The Tanjung Formation is one of the coal bearing formations in the Barito Basin, South Kalimantan. The coal seams in the Tanjung Formation in the Arang Alus area have 4 (four) seams,there are seam A, B, C, and D. The age of these coal seams are Eocene - Oligocene with a thickness between 0.5 - 2 meters. This study aims to determine the characteristics of micropore fractal and methane gas absorption from coal samples taken by channel sampling on exposed coal in the open pit. The method used is SEM analysis, vitrinite reflectance (Ro,max), adsorption isotherm, and fractal calculation. The four coal seams based on vitrinite reflectance values (0.52 %- 0.62 belong to the sub-bituminous rank. Based on the methane gas absorption capacity for coal seam C of 450 SCF/ton while coal seams A, B and D of 308 SCF/ton, 336 SCF/ton and 407 SCF/ton, the fractal pore dimension value in seam coal  C = 1.963  is higher than seam coal  A = 1.933, B = 1.940 , and D = 1.943. The small size of the fractal pore dimension value caused by the degree of regularity of the micropore distribution in each coal seam methane differences.
DIRECTIONS OF DEVELOPMENT OF INTERACTION OF LOCAL GOVERNMENT BODIES WITH HIGHER EDUCATION INSTITUTIONS
Authors:   Luhansk Taras Shevchenko National University, Kravchenko Olena
Published: January 2023

The relevance of the study of the problem of the development of interaction between local self-government bodies and institutions of higher education is due to the renewal of the system of views on the possibilities of bringing the authorities closer to citizens. The author proved the development of interaction between local self-government bodies and institutions of higher education is based on the use by local self-government bodies of the intellectual potential of universities on mutually beneficial terms. An important aspect of the development of cooperation between local self-government bodies and institutions of higher education is the willingness of local authorities to cooperate with universities of various profiles.It is proposed to use the positive experience of European countries and the USA regarding the integration of universities in managing the development of the region, region, and country. Indicators of the development of cooperation between local self-government bodies and universities include: use of the intellectual potential of universities in managing the socio-economic development of territories; signing agreements of local self-government bodies with institutions of higher education of cooperation on mutually beneficial terms; raising the professional level of officials in institutions of higher education (training and advanced training). The author identified directions for the development of interaction between local self-government bodies and institutions of higher education: implementation of various forms of interaction between local self-government bodies and institutions of higher education in order to use the intellectual potential of universities in the activities of local self-government bodies; determination of performance indicators of local self-government bodies in interaction with institutions of higher education; realization of joint projects of informational, analytical and research, charitable and social direction, etc; increasing the professional competence of officials of local self-government bodies (through training, advanced training within the relevant university).
LOCAL INITIATIVES AS A PUBLIC PARTICIPATION TOOL: LEGAL ASPECTS AND DIGITAL TRANSFORMATION
Authors:   Poltava State Agrarian University, Shchetinina Tatyana
Published: January 2023

The article examines the main issues regarding local initiatives as one of the tools of public participation. The main problem of the modern development of local self-government in Ukraine is the involvement of the widest possible circle of the public in interaction with local authorities, the activation of the population to participate in the management of the territorial community. The purpose of this study is to analyze legal regulation and the practice of using local initiatives as one of the tools of public participation in interaction with local self- government bodies. The analysis of the legislative framework made it possible to determine that the legal status of local initiatives in Ukraine is defined quite succinctly and generally. In order to improve the legal framework, an attempt was made to develop a separate law, which was never implemented. The main issues of the procedure for the introduction of local initiatives are assigned to the normative acts of local self-government bodies. The presence of a certain identity between local initiatives and a collective appeal, proposal, and electronic petition was noted. A comparative analysis of the practice of using these participation tools in the community was conducted. Analytical information was used regarding the introduction of local initiatives and electronic petitions in the interaction of the community with the Lviv City Council. It has been established that townspeople gave a significant preference to electronic petitions, as a more convenient modern way of conveying their opinion to the authorities. According to the results of the study, a significant impact of digital technologies on the process of using public participation tools in local self- government was determined. It was noted that the realities of today require providing the possibility of using participation tools not only in an offline format (as it is currently defined for local initiatives), but also in an online format. It is emphasized that the use of an offline format for the practice of local initiatives significantly reduces the interest in this participation tool from the public.
THEORETICAL ASPECTS OF THE FORMATION AND DEVELOPMENT OF DIGITAL DEMOCRACY IN UKRAINE
Authors:   National Aerospace University ", Diegtiar Andrii ,   Kharkiv Aviation Institute"
Published: January 2023

The article summarizes theoretical aspects of the formation and development of Digital Democracy in Ukraine. The main features of digital democracy are revealed: Digital Democracy assumes that most of its forms are based on the direct participation of citizens in democratic processes; it is characterized by the breadth of coverage of citizens, since everyone connected to the internet space can become a participant in certain democratic processes; one of the essential features of this democracy is its reliance on transparency, informing citizens; Digital Democracy makes the boundaries of individual and public spaces, civil society and state power moving, including the joint search for political solutions, which increases the legitimacy of the latter, etc. Forms of digital democracy can be classified on various grounds, for example, by the source of their origin: forms created by public law institutions in digital reality; forms of democracy in digital reality that have emerged within civil society itself. According to the model of functioning of Digital Democracy: these can be models with mechanisms for using state participation, or based only on civil society, or representing a certain symbiosis of the state and civil society. The content aspects of democratic procedures implemented in digital democracy are revealed: internet voting; network communication of citizens in the internet space; electronic collection of signatures under appeals, petitions, etc.; formation of civil society institutions in digital reality; online conducting of various campaigns, dissemination of political information, mobilization of internet users; online human rights activities; implementation of the controlling function of civil society over various spheres of public life, including state / Municipal Administration through the provision of public disclosure of information in the network (transparency of Information, its availability)and reporting requirements of government structures; implementation of the function of forcing government structures to make decisions produced by civil society, hence, a mixed model of direct and indirect forms of democracy through digital information and communication technologies.
Female Genital Schistosomiasis, a Neglected Differential of Cervical Precancerous and Cancerous Lesion: a Wakeup Call for on-Job Training for Healthcare Workers in Endemic Areas
Authors:   Department of Obstetrics and Gynecology, Weill Bugando School of Medicine, Catholic University of Healthy and Allied Sciences, Mwanza, Tanzania, GK Kaizilege , R Kiritta ,   Department of Obstetrics and Gynecology, Weill Bugando School of Medicine, Catholic University of Healthy and Allied Sciences, Mwanza, Tanzania, C Chuma ,   Department of Obstetrics and Gynecology, Weill Bugando School of Medicine, Catholic University of Healthy and Allied Sciences, Mwanza, Tanzania, E Ndaboine ,   Department of Obstetrics and Gynecology, Weill Bugando School of Medicine, Catholic University of Healthy and Allied Sciences, Mwanza, Tanzania, O Ottoman ,   Department of Pathology, Weill Bugando School of Medicine, Catholic University of Healthy and Allied Sciences, Mwanza, Tanzania, E Elias ,   Department of Pathology, Weill Bugando School of Medicine, Catholic University of Healthy and Allied Sciences, Mwanza, Tanzania, MM Zinga ,   Department of Parasitology, Weill Bugando School of Medicine, Catholic University of Healthy and Allied Sciences, Mwanza, Tanzania, HD Mazigo ,   Department of Parasitology, Weill Bugando School of Medicine, Catholic University of Healthy and Allied Sciences, Mwanza, Tanzania
Published: January 2023

Background: Female genital schistosomiasis is a gynecological disease caused by Schistosoma haematobium. The uterine cervix appears to be the most affected area with most cases found in sub-Saharan Africa. Though both males and females can be affected, the consequences of genital schistosomiasis are more pronounced in females with reported increased risk of HIV transmission and malignancy of female genitalia. Female genital schistosomiasis of the cervix shares similarities in presentation to those of cervical intraepithelial neoplasm and sexual transmitted infections, making diagnosis challenging and requiring high degree of suspicion. Case Presentation: We report three cases of African women referred to our facility with a presumptive diagnosis of cervical precancerous/cancerous lesion. Initial workout at our facility was in keeping with early stages of cervical precancerous/cancerous lesion that necessitated excision as per standardized protocol. Histopathological analysis of excised tissue revealed schistosomiasis of the cervix. Conclusion: Schistosomiasis of the cervix shares similarities with cervical precancerous/cancerous lesions and should be suspected in women presenting with chronic inflammatory conditions of the cervix or features suggestive of precancerous/cancerous cervical lesions. Screening for female genital schistosomiasis should be incorporated in an already existing screening protocol for cervical cancer and sexual transmitted diseases.
Management of Severe Head Trauma in a Parturient in Pregnancy Labor
Authors:   Department of Obstetrical and Gynecological Resuscitation, Souissi Maternity Hospital, University Hospital Center Ibn Sina, Rabat, Morocco, M Afrikh , A Elhadloussi ,   Department of Obstetrical and Gynecological Resuscitation, Souissi Maternity Hospital, University Hospital Center Ibn Sina, Rabat, Morocco, O Belarabi ,   Department of Obstetrical and Gynecological Resuscitation, Souissi Maternity Hospital, University Hospital Center Ibn Sina, Rabat, Morocco, A Saoud Tazi ,   Department of Obstetrical and Gynecological Resuscitation, Souissi Maternity Hospital, University Hospital Center Ibn Sina, Rabat, Morocco
Published: January 2023

Trauma is the first cause of non-obstetric death in pregnant women and its management involves several disciplines: anesthesia, resuscitation, obstetrics, neurosurgery and radiology. We report in this observation the case of a woman from the Souissi Maternity Hospital in Rabat who suffered a head injury following a car accident.
Complete Avulsion of the Nipple-Areolar Complex Treated by One-Stage Reconstruction Using a Graft In Situ
Authors:   Department of Breast Surgery, West China Hospital, Sichuan University, Chengdu, China, Y-H Wu , Q-W Tan ,   Department of Breast Surgery, Clinical Research Center for breast, West China Hospital, Sichuan University, Chengdu, China, S Lu ,   Department of Thyroid and Breast Surgery, Qiandongnan People’s Hospital, Guizhou, China, W-F Zhang ,   Department of Thyroid and Breast Surgery, Qiandongnan People’s Hospital, Guizhou, China, Q Lv ,   Department of Thyroid and Breast Surgery, Qiandongnan People’s Hospital, Guizhou, China, J Chen ,   Department of Breast Surgery, West China Hospital, Sichuan University, Chengdu, China
Published: January 2023

Background: Cases of complete avulsion of the Nipple-Areolar Complex (NAC) due to trauma are rare. The avulsed NAC can be replanted in situ if the vessels and nerves were anastomosed appropriately. However, this type of surgery is more complex, and requires longer operation times and the surgeon with training and experience of anastomosis of small vessels. We are looking for a more simple and effective method, which can be widely used. Case Presentation: We reported a 19-year old girl whose left NAC had been completely avulsed by accident. We used a simple one-stage reconstruction surgery to modify the avulsed NAC as a tissue graft in situ. After 24 months, the reconstructed left nipple showed a similar appearance to the right. In addition, the patient showed high satisfaction with her breast appearance. Discussion: Tissue graft in situ might be a simple, safe and reliable surgical procedure for completely NAC post-avulsion transplantation.
Adding on Addison’s: A Case Report of Rare Co-Existent Pathology Complicating Acute Pre-Eclampsia (PET) in Pregnancy
Authors:   Department of Obstetrics & Gynaecology, Mildura Base Public Hospital, Mildura 3500 VIC, Australia, A Aboda , M Cahyadi ,   Department of Obstetrics & Gynaecology, Mildura Base Public Hospital, Mildura 3500 VIC, Australia, A Paalendra ,   Department of Obstetrics & Gynaecology, Mildura Base Public Hospital, Mildura 3500 VIC, Australia, R Miller ,   Department of Obstetrics & Gynaecology, Mildura Base Public Hospital, Mildura 3500 VIC, Australia, T Carney ,   Department of Obstetrics & Gynaecology, Mildura Base Public Hospital, Mildura 3500 VIC, Australia, S Aali ,   Department of Obstetrics & Gynaecology, Mildura Base Public Hospital, Mildura 3500 VIC, Australia, B McCully ,   Department of Obstetrics & Gynaecology, Mildura Base Public Hospital, Mildura 3500 VIC, Australia
Published: January 2023

Addison’s disease is a rare condition, which world-wide, may affect many millions of people. In pregnancy however, it has been rarely reported and, in this setting, remains poorly understood. What we do know, is that it is an endocrine disorder characterized by adrenal insufficiency leading to decreased production of cortical hormones including most notably, cortisol, but also the androgens and aldosterone. The sequaelae may be varied but most significantly, can lead to a loss of the body’s normal resilience to stress and injury. We present the case of a 35-year-old woman who presented in late pregnancy with signs and symptoms of fulminating pre-eclampsia (PET). Paradoxically, she was found to have electrolyte abnormalities which persisted despite appropriate treatment. These were suggestive of an underlying endocrine disorder and she was subsequently diagnosed with atypical Addison’s disease. With appropriate management, she was stabilized and delivered safely. We report this as a rare example of newly diagnosed Addison’s disease discovered for the first time in late pregnancy. It highlights that although rarely diagnosed, early identification can help avoid potentially life-threatening sequalae such as acute adrenal insufficiency as well as complications including preterm birth, neonatal hypoglycaemia and prolonged hospital admission. This calls for ongoing vigilance in clinical care, and the continuous improvement of shared knowledge through collaborative communication and awareness of evidence based, best practice guidelines.
One Case of Unilateral Intractable Localized Plaque Psoriasis Treated by Herbal Thread Moxibustion Combined with Blood Pricking
Authors:   Department of Acupuncture and Rehabilitation, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510000, Guangdong, China, LJ Jing , L Yiqian ,   Guangzhou University of TCM, Guangzhou 510000, Guangdong, China, XZ Qiong ,   Department of Acupuncture and Rehabilitation, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510000, Guangdong, China
Published: January 2023

Chronic plaque psoriasis is an inflammatory disease. Due to the complex interaction of genetic and environmental factors, immune related cytokine imbalance leads to abnormal epidermal proliferation. A 73 year old female patient with 20-year-old intractable psoriasis improved significantly after 2 weeks of treatment with traditional Zhuang medicine. Moxibustion with medicinal thread combined with pricking and bloodletting may be a good choice for the treatment of psoriasis in the future.
Review of Water Problems in the Era of COVID-19
Authors:   Department Leal Science, Universidad de onora, Mexico, Gonzalez Maria Del Rosario Molina , Campas Celia Yaneth Quiroz ,   Department Administrative Sciences, Instituto Tecnologico de Sonora, Mexico, Ruiz Gilberto Bermudez ,   Department Economy, Universidad Anahuac, Mexico, Morales Francisco Espinoza ,   Department Administrative Science, Universidad de Sonora, Mexico, Lirios Cruz Garcia ,   Department Social Work, Universidad Autonoma del Estado de, Mexico
Published: January 2023

The objective of this work was to establish press framing networks around the water problem in Mexico City. A documentary study was carried out with press releases related to shortages, shortages, unhealthiness and famine during the period 2019 to 2021. The results show a discreet framing of the press, although the structure of its framing suggests the representation of the problem in the shortage and the solution in the increase in rates, suggesting the extension of the investigation to other scenarios and samples of coverage of the printed media.
It’s a Fact: The Pandemic is Still Going On
Authors:   Faculty of Science and Philosophy, Universidad Peruana Cayetano Heredia, Peru, M Cavani , W Riofrío ,   Department of Statistics, Demography, Humanities and Social Sciences, Faculty of Science and Philosophy, Universidad Peruana Cayetano Heredia, Peru
Published: January 2023

In the following perspective, we highlight the effect of mutations in the Omicron BA.4 and BA.5 subvariants and how they affect epidemiological parameters. Based on the scientific evidence, we hypothesize the evolutionary path that the SARS-CoV-2 virus could follow and the expectations for the future of the pandemic.
Personal Bullying and Nurses Turnover Intentions in Public Health Sector of Lahore, Pakistan
Authors:   Post-RN Student, Department of Nursing, The Superior College, Lahore, Pakistan, A Tabassum , A Tabassum ,   Post-RN Student, Department of Nursing, The Superior College, Lahore, Pakistan, A Sultan ,   Post-RN Student, Post Graduate College of Nursing, Lahore, Pakistan
Published: January 2023

Workplace bullying has an adverse effect on the physical and mental health of nurses which are the strength of the health care system. The main objective of this study was to investigate the effect of workplace bullying among nurses and turnover intention in the public sector of Pakistan. This study included an explanatory consecutive mixed method. In this quantitative study, a questionnaire was filled from 187 registered nurses of public sector hospitals of Pakistan. The sample size was analyzed by a specific formula through SPSS version 21. The present study analyzed the psychological stress level faced by nurses in their workplace. In this research, we use a descriptive qualitative study design. Results from structural equation modeling showed the direct as well as an indirect effect on nurses turnover intentions by personal bullying. People, they keep the experiences to themselves and bear with the difficulties coming across rather than facing social problems. This is why professional bullying is very high in our hospitals but the nurses are unwilling to leaving their jobs. Workplace bullying in the nursing profession can cost quite a lot to the Patients, hospitals and the nurses themselves. Consequently, the current nursing shortage in hospitals even worse.
Ruptured Sinus of Valsalva Aneurysm from Left Coronary Sinus with Different Causes
Authors:   Department of Ultrasound, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China, R Kang , M Han ,   Queen Mary School, Nanchang University, Nanchang, Jiangxi, China, C Zhang ,   Department of Ultrasound, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China
Published: January 2023

Objective: Analysis of three cases in which the clinical diagnosis was ruptured sinus of Valsalva aneurysm (RSVA) from left coronary sinus, combined with similar cases in the literature, to summarize the etiology of RSVA. Methods: Retrospective analysis of three cases of RSVA diagnosed in our hospital from 2009 to 2021. Their general condition, examination and treatment were analyzed, and the etiology of the sinus of Valsalva aneurysm (SVA) was summarized in relation to similar cases reported in the literature. Results: All three cases were diagnosed as RSVA from left coronary sinus with a clear etiology of congenital SVA, Behcet’s disease and infective endocarditis, respectively. They all underwent successful surgical treatment. In the literature, there were 12 cases of SVA from left coronary sinus of definite etiology, 10 of which ruptured. Conclusions: SVA from left coronary sinus is a rare disease with a complex etiology, and RSVA is one of the most serious complications of SVA. Exploring the etiology of SVA will help to prevent the serious complications of RSVA by targeting the etiology for treatment and timely surgical intervention.
Total Retinal Detachment Following Traditional Couching
Authors:   Department of Ophthalmology, Military Hospital, Mohammed V University, Rabat, Morocco, M Aachak , I Jeddou ,   Department of Ophthalmology, Military Hospital, Mohammed V University, Rabat, Morocco, H Boui ,   Department of Ophthalmology, Military Hospital, Mohammed V University, Rabat, Morocco, H Brarou ,   Department of Ophthalmology, Military Hospital, Mohammed V University, Rabat, Morocco, T Abdellaoui ,   Department of Ophthalmology, Military Hospital, Mohammed V University, Rabat, Morocco, F El Asri ,   Department of Ophthalmology, Military Hospital, Mohammed V University, Rabat, Morocco, Y Mouzarii ,   Department of Ophthalmology, Military Hospital, Mohammed V University, Rabat, Morocco, K Reda ,   Department of Ophthalmology, Military Hospital, Mohammed V University, Rabat, Morocco, A Oubaaz ,   Department of Ophthalmology, Military Hospital, Mohammed V University, Rabat, Morocco
Published: January 2023

A 65-year-old patient with no notable history, from low socioeconomic status, presented to the ophthalmology clinic for visual impairment of the left eye three months after a traditional couching. Visual acuity was limited to light perception. Slit-lamp examination showed cells and flare in the anterior segment and the vitreous. Fundus examination showed a complete retinal detachment including the fovea with proliferative vitreoretinopathy stage B and two large peripheric retinal tears inferiorly contiguous to the crystalline lens. Surgical treatment was based on pars plana vitrectomy with phacofragmentation of the crystalline lens, pneumatic retinopexy and endophotocoagulation of the retinal tears. Clinical evolution was marked by the improvement of the visual acuity to 20/200 two months after surgery.
A Case of Bilateral Pseudo Papilledema Revealing a Leber’s Hereditary Optic Neuropathy
Authors:   Department of Ophthalmology, Military Hospital, Mohammed V University, Rabat, Morocco, M Aachak , H Brarou ,   Department of Ophthalmology, Military Hospital, Mohammed V University, Rabat, Morocco, H Boui ,   Department of Ophthalmology, Military Hospital, Mohammed V University, Rabat, Morocco, I Jeddou ,   Department of Ophthalmology, Military Hospital, Mohammed V University, Rabat, Morocco, T Abdellaoui ,   Department of Ophthalmology, Military Hospital, Mohammed V University, Rabat, Morocco, F El Asri ,   Department of Ophthalmology, Military Hospital, Mohammed V University, Rabat, Morocco, Y Mouzarii ,   Department of Ophthalmology, Military Hospital, Mohammed V University, Rabat, Morocco, K Reda ,   Department of Ophthalmology, Military Hospital, Mohammed V University, Rabat, Morocco, A Oubaaz ,   Department of Ophthalmology, Military Hospital, Mohammed V University, Rabat, Morocco
Published: January 2023

Leber Hereditary Optic Neuropathy (LHON) is a mitochondrial disease caused by mutations in mitochondrial DNA affecting the respiratory complex I and leading to the death of retinal ganglion cells (RGCs) [1]. It is characterized by sudden onset and usually severe bilateral loss of central vision, predominantly in young men [2]. The risk of vision loss is 50% among men and 10% among women who carry LHON primary mutations in the mitochondrial DNA [3]. We report an atypic case of LHON in a young 11 years old girl.
Cerulean Cataract
Authors:   Department of Ophthalmology, Hopitaldes Spécialités, Rabat, Morocco, HE Belidi , Y Saoiabi ,   Department of Ophthalmology, Hopitaldes Spécialités, Rabat, Morocco, I Boumehdi ,   Department of Ophthalmology, Hopitaldes Spécialités, Rabat, Morocco, O Cherkaoui ,   Department of Ophthalmology, Hopitaldes Spécialités, Rabat, Morocco
Published: January 2023

A 14-year-old girl presented with a two years history of gradual decrease of vision in both eyes. The best corrected visual acuity was 0, 3 LogMARin both eyes. The examination of the anterior segment on slit-lamp of both eyes releveled multiple tiny bluish-white opacities distributed in the lensnucleus and cortexin the form of concentric circles corresponding to a congenital cerulean cataract. No other abnormality was observed in the slit lamp in both eyes. Phacoemulsification surgery was planned for each eye with a good evolution.
Synthesis of BCP-Based Straight-Shaped Diphosphine Ligands
Authors: Takano Hideaki , Katsuyama Hitomi , Hayashi Hiroki , Harukawa Miyu , Tsurui Makoto , Shoji Sunao , Hasegawa Yasuchika , Maeda Satoshi , Mita Tsuyoshi
Published: January 2023

[1.1.1]Propellane, which is structurally simple and compact, exhibits promising potential for the synthesis of disubstituted straight-shaped bicyclo[1.1.1]pentane (BCP) compounds by manipulation of its highly reactive internal C–C bond. BCPs are considered to be isosteres of 1,4-disubstituted benzenes, which have found broad applications in the areas of functional molecules and drug discovery. The internal C–C single bond of [1.1.1]propellane is regarded as a change-shift bond, which can be readily cleaved by radical or ionic means to construct BCPs. We herein report a novel synthetic method for (un)symmetric diphosphines based on the BCP motif, which can be interpreted as isosteres of 1,4-bis(diphenylphosphino)benzenes. The obtained BCP-diphosphine derivatives were used to generate a straight-shaped Au complex and a Eu-based coordination polymer.
Brønsted Acid Catalyzed Asymmetric Synthesis of cis-Tetrahydrocannabinoids
Authors: Dorsch Caroline , Schneider Christoph
Published: January 2023

We report herein the catalytic asymmetric cyclization of 1-aryl terpenols to afford enantiomerically highly enriched cis-tetrahydrocannabinoid scaffolds in a single step. As powerful chiral catalysts strongly acidic imidodiphosphorimidates (IDPis) have been identified which furnish the products with good yields and excellent enantioselectivity. Upon MOM-deprotection some naturally occurring cannabimimetica such as (-)-cis-Δ9-tetrahydrocannabinol and ( )-perrotettinene as well as some unnatural analogues were made accessible along a merely 3-step biomimetic sequence.
Characteristics of the Yeast Strain Candida ethanolica BKM Y-2300 T Productivity
Authors:   Irkutsk National Research Technical University, Kiryukhina А. S.
Published: January 2023

In the modern world, the applying of microorganisms as producers of various valuable compounds is relevant. Such producers are often yeast Candida, which are used to synthesize various products – proteins, enzymes, vitamins. One of the representatives of the genus, Candida ethanolica, is interesting because it uses ethanol as a carbon source. Synthetic ethanol is a convenient raw material for the biotechnological process, since it has a lower cost compared to chemically pure carbohydrates, is well water-soluble and does not contain impurities. Since the C. ethanolica is insufficiently studied as a biotechnological object, the aim of the research was the obtaining new information about the strain Candida ethanolica (BKM strain Y-2300 T). The main morphological, cultural, physiological and biochemical properties of the yeast strain were studied. Part of them turned out to be typical for most yeast of genus Candida. In addition, the strain was facultatively anaerobic with respect to oxygen. In addition, the most suitable carbon source and its optimal concentration were selected for this strain. It showed the greatest preference to ethanol when grown in the presence of various carbon sources (carbohydrates, alcohols, oils). The biggest increasing of cell number and biomass was observed if an ethanol content in the medium was of 1.5% vol. The optimal conditions for laboratory cultivation for this strain were determined: aeration degree (200 rpm); temperature 37 ° C; pH of the medium (7.0). The yeast were resistant to salt concentrations from 4.5 to 5.0%. The strain was also tested for the activity of some enzymes important in the food and processing industry: saccharolytic, proteolytic, lipolytic, amylolytic, catalase, and urease. The most active enzymes were that hydrolyze sucrose, lipids and proteins. The ability of C. ethanolica to intracellular synthesis of protein, carbohydrates and vitamins was evaluated. This strain formed a small amount of carbohydrates and vitamins, but its protein quantity was quite substantial. The maximum amount of protein in the cells accumulated after 4 hours (from the start of cultivation) and was 31.10 %. This value was at the level of some well-known producers of cell protein. Thus, the studied strain is a potentially valuable producer for the biotechnology industry as a source of cell protein, glycosidase, lipase and protease. Further studies that are more specific are required to exploit the biosynthetic potential of this strain in industry.