Prevalence and Determinants of Fatigue in Patients with IBD: A Cross-Sectional Survey from the GETAID
Authors: Amiot Aurelien , Chaibi Sayma , Bouhnik Yoram , Serrero Melanie , Filippi Jerome , Roblin Xavier , Bourrier Anne , Bouguen Guillaume , Franchimont Denis , Savoye Guillaume , Buisson Anthony , Louis Edouard , Nancey Stephane , Abitbol Vered , Reimund Jean-Marie , DeWit Olivier , Vuitton Lucine , Mathieu Nicolas , Peyrin-Biroulet Laurent , Gilletta Cyrielle , Allez Matthieu , Viennot Stephanie , Le Berre Catherine , Dib Nina , Brixi Hedia , Painchart Claire , Plastaras Laurianne , Altwegg Romain , Fumery Mathurin , Caillo Ludovic , Laharie David , Nachury Maria ,   GETAID-patient experience study group, Amiot Aurelien , Tadbiri Sara , Gagniere Charlotte , Tannoury Jenny , Nachury Maria , Pariente Benjamin , Wils Pauline , Bouhnik Yoram , Stefanescu Carmen , Treton Xavier , Martins Carole , Uzzan Mathieu , Serrero Melanie , Filippi Jerome , Hébuterne Xavier , Arab Nadia , Cluzeau Virginie , Roblin Xavier , Del Tedesco Emilie , Beaugerie Laurent , Seksik Philippe , Bourrier Anne , Landmann Cecilia , Kirchgesner Julien , Sokol Harry , Bouguen Guillaume , Siproudhis Laurent , DeWitte Marie , Franchimont Denis , Savoye Guillaume , Buisson Anthony , Louis Edouard , Reenaers Catherine , Nancey Stephane , Boschetti Gilles , Gay Claire , Danion Pauline , Flourié Bernard , Abitbol Vered , Malamut Georgia , Reimund Jean-Marie , Caron Benedicte , DeWitt. Olivier , Vuitton Lucine , Mathieu Nicolas , Pestour Sandie , Chateau Thomas , Peyrin-Biroulet Laurent , Zallot Camille , Gilletta Cyrielle , Allez Matthieu , Gornet Jean-Marc , Baudry Clotilde , Viennot Stephanie , Bourreille Arnaud , Trang-Poisson Caroline , Dib Nina , Brixi Hedi , Cadiot Guillaume , Boualit Medina , Painchart Claire , Plastaras Laurianne , Altwegg Romain , Boivineau Lucile , Fumery Mathurin , Caillo Ludovic , Laharie David , Riviere Pauline , Poullenot Florian , Coffin Benoit , Duboc Henri , Nahon Stephane , Tavernier Noemie , Simon Marion , Coulibaly Baya , Amil Morgane , Nicolas Duveau , Khater Sherine , Kaassis Mehdi , Goutorbe Felix , Moussata Driffa 
Published: March 2023

Background

Fatigue is commonly reported by patients with inflammatory bowel disease [IBD], but the determinants of IBD-related fatigue have yet to be determined.

Aims

To identify the factors associated with fatigue in a large population of patients with IBD.

Patients and Methods

Fatigue and nine other IBD-related disability dimensions were assessed in a cohort of 1704 consecutive patients with IBD using the IBD-disk questionnaire in a cross-sectional survey of 42 French and Belgian centres. Fatigue and severe fatigue were defined as energy subscores &gt;5 and &gt;7, respectively. Determinants of fatigue were assessed using univariate and multivariate analyses (odds ratios [ORs] are provided with 95% confidence intervals).

Results

The prevalence rates of fatigue and severe fatigue were 54.1% and 37.1%, respectively. Both fatigue and severe fatigue were significantly higher in patients with active disease than in patients with inactive disease [64.9% vs 44.7% and 47.4% vs 28.6%, respectively; p &lt; 0.001 for both comparisons]. In the multivariate analysis stratified by age, sex, type of IBD and IBD activity, fatigue was associated with age &gt;40 years (OR = 0.71 [0.54–0.93]), female sex (OR = 1.48 [1.13–1.93]) and IBD-related sick leave (OR = 1.61 [1.19–2.16]), and joint pain (OR = 1.60 [1.17–2.18]), abdominal pain (OR = 1.78 [1.29–2.45]), regulating defecation (OR = 1.67 [1.20–2.32]), education and work (OR = 1.96 [1.40–2.75]), body image (OR = 1.38 [1.02–1.86]), sleep (OR = 3.60 [2.66–4.88]) and emotions (OR = 3.60 [2.66–4.88]) subscores &gt;5.

Conclusion

Determinants of fatigue are not restricted to IBD-related factors but also include social factors, sleep and emotional disturbances, thus supporting a holistic approach to IBD patient care.