bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of microclimatic physical factors on in vitro morphogenesis of plants: a systematic review
Authors: Gautam Nikita , Faroda Priyanka , Agarwal Tanvi , Harish  , Gupta Amit Kumar
Published: April 2024

Biotechnology has revolutionized plant propagation by providing plant tissue culture as a rising alternative platform to conventional methods. In the present scenario, plant tissue culture becomes the key technique for the large-scale production and conservation of germplasm, maintenance of genetic stability, and meets out the economic demands of plant and plant products. It is the science of artificially growing test tube plantlets under optimized microclimatic conditions isolated from the external environment. This micro-scale environment resembles the natural environment consisting of culture vessels, humidity, gases, light irradiation, spectrum, temperature, nutritional media, and its constituents as major growth-affecting factors. The efficient architectural development of any genotype depends on these factors and requires a specifically optimized climate. Here, we are reviewing the interaction of physical factors of in vitro artificial climate including culture vessel, light, and temperature with the developing plantlets. The outcomes can increase the understanding of the developmental response of plants toward their environment in the recently changing climatic conditions. Further, this can also eliminate the challenges of cost, labor, and timings and introduce the advancements of efficient large-scale production of plant and plant products which will be effective in fulfilling the population demands.
On Helping One's Neighbor
Authors: Ranganathan Bharat
Published: April 2024

Exploring what he calls 'the moral horror that is severe poverty,' Bharat Ranganathan develops a demanding account of the obligations that affluent people have to assist severely impoverished people. He argues that this is an immediate ethical as much as a social or structural imperative. Noting that developmental economists and moral and political philosophers have focused on wealth inequalities in increasingly sophisticated ways, Ranganathan observes that – within religious ethics – normative issues around severe poverty have nevertheless received insufficient attention. Bringing together general moral, religious, and philosophical principles with particular economic, social, and political realities, and engaging constructively with the writings of John Rawls and Peter Singer, this passionately argued book boldly challenges deleterious trends within ethics by unpacking, in a much more systematic way than hitherto, the pressing dilemmas around acute impoverishment. It will find an eager readership among scholars of religion, ethics, developmental studies, and theology.
Abating CO2 and non-CO2 emissions with hydrogen propulsion
Authors: Mourouzidis C. , Singh G. , Sun X. , Huete J. , Nalianda D. , Nikolaidis T. , Sethi V. , Rolt A. , Goodger E. , Pilidis P.
Published: April 2024

This contribution focuses on the abatement with hydrogen of CO2 and non-CO2 emissions. It is agenda-setting in two respects. Firstly, it challenges the globally accepted hydrocarbon sustainable aviation fuel (SAF) pathway to sustainability and recommends that our industry accelerates along the hydrogen pathway to ‘green’ aviation. Secondly, it reports a philosophical and analytical investigation of appropriate accuracy on abatement strategies for nitrogen oxides and contrails of large hydrogen airliners. For the second contribution, a comparison is made of nitrogen oxide emissions and contrail avoidance options of two hydrogen airliners and a conventional airliner of similar passenger capacity. The hydrogen aircraft are representative of the first and second innovation waves where the main difference is the weight of the hydrogen tanks. Flights of 1000, 2000, 4000 and 8000 nautical miles are explored. Cranfield’s state of the art simulators for propulsion system integration and gas turbine performance (Orion and Turbomatch) were used for this. There are two primary contributions to knowledge. The first is a new set of questions to be asked of SAF and hydrogen decarbonising features. The second is the quantification of the benefits from hydrogen on non-CO2 emissions. For the second generation of long-range hydrogen-fuelled aircraft having gas turbine propulsion, lighter tanks (needing less thrust and lower gas temperatures) are anticipated to reduce NOx emissions by over 20%; in the case of contrails, the preliminary findings indicate that regardless of the fuel, contrails could largely be avoided with fuel-burn penalties of a few per cent. Mitigating action is only needed for a small fraction of flights. For conventional aircraft this penalty results in more CO2, while for hydrogen aircraft the additional emission is water vapour. The conclusion is that our research community should continue to consider hydrogen as the key ‘greening’ option for aviation, notwithstanding the very significant costs of transition.
Improvement of UAV thrust using the BSO algorithm-based ANFIS model
Authors: Konar M. , Arık Hatipoğlu S. , Akpınar M.
Published: April 2024

Unmanned aerial vehicles (UAVs), which are available in our lives in many areas today, bring with them new expectations and needs along with developing technology. In order to meet these expectations and needs, main subjects such as reducing energy consumption, increasing thrust and endurance, must be taken into account in UAV designs. In this study, Backtracking search optimisation (BSO) algorithm-based adaptive neuro-fuzzy inference system (ANFIS) model is proposed for the first time to improve UAV thrust. For this purpose, first, different batteries and propellers were tested on the thrust measuring device and a data set was obtained. Propeller diameter and pitch, current, voltage and the electronic speed controller (ESC) signal were selected as input, and UAV thrust was selected as output. ANFIS was used to relate input and output parameters that do not have a direct relationship between them. In order to determine the ANFIS parameters at the optimum value, ANFIS was trained with the obtained data set by using BSO algorithm. Then, the objective function based on the optimum ANFIS structure was integrated into BSO algorithm, and the input values that gave the optimum thrust were calculated using BSO algorithm. Simulation results, in which parameters such as engine, battery and propeller affecting the thrust are taken into account equally, emphasise that the proposed method can be used effectively in improving the UAV thrust. This hybrid method, consisting of ANFIS and BSO algorithm, can reduce the cost and time loss in UAV designs and allows many possibilities to be tested.
An extreme worst-case risk measure by expectile
Authors: Hu Yanlin , Chen Yu , Mao Tiantian
Published: April 2024

Expectiles have received increasing attention as a risk measure in risk management because of their coherency and elicitability at the level
$\alpha\geq1/2$
. With a view to practical risk assessments, this paper delves into the worst-case expectile, where only partial information on the underlying distribution is available and there is no closed-form representation. We explore the asymptotic behavior of the worst-case expectile on two specified ambiguity sets: one is through the Wasserstein distance from a reference distribution and transforms this problem into a convex optimization problem via the well-known Kusuoka representation, and the other is induced by higher moment constraints. We obtain precise results in some special cases; nevertheless, there are no unified closed-form solutions. We aim to fully characterize the extreme behaviors; that is, we pursue an approximate solution as the level
$\alpha $
tends to 1, which is aesthetically pleasing. As an application of our technique, we investigate the ambiguity set induced by higher moment conditions. Finally, we compare our worst-case expectile approach with a more conservative method based on stochastic order, which is referred to as ‘model aggregation’.
Trends in publication and levels of social determinants of health reporting in Journal of Clinical and Translational Science from 2017 to 2023
Authors: Levites Strekalova Yulia A. , Wang Xiangren , Sanchez Orlando , Midence Sara
Published: April 2024

Social determinants of health affect clinical and translational research processes and outcomes but remain underreported in empirical studies. This scoping review examined the rate and types of social determinants of health (SDoH) variables included in the JCTS translational research studies published between 2017 and 2023 and included 129 studies. Most papers (91.7%) reported at least one SDoH variable with age, race and ethnicity, and sex included most often. Future studies to inform the role of SDoH data in translational research and science are recommended, and a draft SDoH data checklist is provided.
Strange Figures: The Female Founders at the Margins of Hannah Arendt's Theory of Political Beginning
Authors: Frost Catherine
Published: April 2024

Without females included in the ranks of political founder, Hannah Arendt's theory of political beginning looks dangerously romanticized. Arendt's founder is someone who rises to the challenge of their times, diverting history and renewing public spirit in the process. But despite a methodology that called for recovering the “rich and strange” from the past Arendt does not address the female founders that populate the myths and traditions she cites as instructive. These figures exemplify the unsettling forces and relationality she associates with beginning, but they also signal the high cost of action for the marginalized, including the difficulty some actors face in being recognized at all. If, as she suggests, the founder's persona provides an avenue of recall for the perplexing experience of beginning, then female founders support this recall magnificently while adding a tragic and troubling note that Arendt omits. Their reintroduction into her theory of political beginning takes the shine off her otherwise heroized and happy account.
Bacterial contamination of surgical gloves during clean orthopedic surgery
Authors: Lee Jee Young , Yun Sang Hee , Kang Jae Won , Kong Gyu Min
Published: April 2024

This study examines the presence of bacterial contamination on surgical gloves and suggests appropriate measures for an aseptic surgical environment. To prevent glove contamination during surgery, surgeons and assistants should change gloves periodically, and scrub nurses should be careful when opening packages and handing over implants.
Separating the rash from the chaff: novel clinical decision support deployed during the mpox outbreak
Authors: Lazarus Jacob E. , Green Chloe V. , Jerry Michelle S. , Germaine Lindsay , McEvoy Dustin S. , Dugdale Caitlin M. , Hysell Kristen M. , Craig Rebecca L. , Paras Molly L. , Heller Howard M. , Ard Kevin L. , Albin John S. , Lee Hang , Shenoy Erica S.
Published: April 2024

A clinical decision support system, EvalMpox, was developed to apply person under investigation (PUI) criteria for patients presenting with rash and to recommend testing for PUIs. Of 668 patients evaluated, an EvalMpox recommendation for testing had a positive predictive value of 35% and a negative predictive value of 99% for a positive mpox test.
Evidence of transmission of New Delhi metallo-β-lactamase-producing Klebsiella pneumoniae through a gastrointestinal endoscope without an elevator channel
Authors: Yang Ann Fan , Sherman Adrienne , Nazarian Elizabeth , Haas Wolfgang , Mehr Jason , Pedrani Michele , Kirn Thomas , Brant Steven , Boruchoff Susan E. , Kaye Keith S. , Mills John P.
Published: April 2024

Objective:

To investigate the source and transmission dynamics of an endoscope-associated New Delhi metallo-β-lactamase-producing Klebsiella pneumonia (NDM-KP) outbreak.

Design:

Epidemiological and genomic investigation.

Setting:

Academic acute care hospital in New Jersey.

Patients:

Five patients with active NDM-KP infection identified on clinical isolates, and four NDM-KP colonized patients identified via rectal swab screening.

Results:

Over a twelve-month period, nine patients were identified with NDM-KP infection or colonization. Whole-genome sequencing (WGS) revealed that all of the identified cases were related by 25 mutational events or less. Seven of the cases were linked to gastrointestinal endoscopic procedures (four clinical cases and three positive screens among patients exposed to endoscopes suspected of transmission). Two cases demonstrated delayed transmission that occurred five months after the initial outbreak, likely through shared usage of a non-therapeutic gastroscope without an elevator channel.

Conclusions:

Although all endoscope cultures in our investigation were negative, the epidemiological link to gastrointestinal endoscopes, the high degree of relatedness via WGS, and the identification of asymptomatic NDM-KP colonization among patients exposed to shared endoscopes make the endoscopic mode of transmission most likely. This investigation highlights the probable transmission of NDM-KP via a gastroscope without an elevator channel, observed several months after an initial outbreak. We hypothesize that persistent mechanical defects may have contributed to the delayed device-related transmission of NDM-KP.
Turning 18 in mental health services: a multicountry qualitative study of service user experiences and views
Authors: Boonstra Anouk , Leijdesdorff Sophie , Street Cathy , Holme Ingrid , van Bodegom Larissa , Franić Tomislav , Appleton Rebecca , Tah Priya , Tuomainen Helena , Tomljenovic Helena , McNicholas Fiona , van Amelsvoort Thérèse ,   MILESTONE Consortium
Published: April 2024

Background:

Worldwide, the division between Child and Adolescent Mental Health Services (CAMHS) and Adult Mental Health Services (AMHS) has frequently resulted in fragmented care with an unprepared, non-gradual transition. To improve continuity of care and other service transition experiences, service user input is essential. However, such previous qualitative studies are from a decade ago or focused on one mental disorder or country. The aim of the present study was to learn from service users’ transition experiences and suggested improvements.

Methods:

Semi-structured interviews were held with young people aged 18–24 and/or parents/caregivers in the United Kingdom, Ireland, the Netherlands and Croatia. Inclusion was based on the experience of specialist mental health care before and after turning 18. Thematic analysis of transcribed and translated interview transcripts was performed using ATLAS.ti 9.

Results:

Main themes of service user experiences included abrupt changes in responsibilities, various barriers and a lack of preparation, communication and ongoing care. Young people expressed a great need for continuity of care. Their suggestions to improve transitional care included early and adequate preparation, joint working, improved communication from and between services, overlapping services, staying at CAMHS for longer and designated youth mental health teams.

Conclusions:

Young people who experienced care before and after turning 18 suggested either altering the age limits of services or ensuring early preparation and communication regarding the transition and finding AHMS. This communication should include general changes when turning 18. Further considerations include increasing collaboration and overlap between CAMHS and AMHS.
Porous media gravity current flow over an interbed layer: the impact of dispersion and distributed drainage
Authors: Sheikhi S. , Flynn M.R.
Published: April 2024

Motivated by buoyancy-driven flows within geological formations, we study the evolution of a (dense) gravity current in a porous medium bisected by a thin interbed layer. The gravity current experiences distributed drainage along this low-permeability boundary. Our theoretical description of this flow takes into account dispersive mass exchange with the surrounding ambient fluid by considering the evolution of the bulk and dispersed phases of the gravity current. In turn, we model basal draining by considering two bookend limits, i.e. no mixing versus perfect mixing in the lower layer. Our formulations are assessed by comparing model predictions against the output of complementary numerical simulations run using COMSOL. Numerical output is essential both for determining the value of the entrainment coefficient used within our theory and for assessing the reasonableness of key modelling assumptions. Our results suggest that the degree of dispersion depends on the dip angle and the depth and permeability of the interbed layer. We further find that the nose position predictions made by our theoretical models are reasonably accurate up to the point where the no mixing model predicts a retraction of the gravity current front. Thereafter, the no mixing model significantly under-predicts, and the perfect mixing model moderately over-predicts, numerical data. Reasons for the failure of the no mixing model are provided, highlighting the importance of convective instabilities in the lower layer. A regime diagram is presented that defines the parametric region where our theoretical models do versus do not yield predictions in good agreement with numerical simulations.
Long-wave instabilities of sloping stratified exchange flows
Authors: Zhu Lu , Atoufi Amir , Lefauve Adrien , Kerswell Rich R. , Linden P.F.
Published: April 2024

We investigate the linear instability of two-layer stratified shear flows in a sloping two-dimensional channel, subject to non-zero longitudinal gravitational forces. We reveal three previously unknown instabilities, distinct from the well-known Kelvin–Helmholtz instability and Holmboe wave instability, in that they have longer wavelengths (of the order of 10 to

$10^3$

shear-layer depths) and often slower growth rates. Importantly, they can grow in background flows with gradient Richardson number

$\gg 1$

, which offers a new mechanism to sustain turbulence and mixing in strongly stratified flows. These instabilities are shown to be generic and relatively insensitive to Reynolds number, Prandtl number, base flow profile and boundary conditions. The nonlinear evolution of these instabilities is investigated through a forced direct numerical simulation, in which the background momentum and density are sustained. The growth of long unstable waves in background flows initially stable to short wave causes a decrease in the local gradient Richardson number. This leads to local nonlinear processes that result in small-scale overturns resembling Kelvin–Helmholtz billows. Our results establish a new energy exchange pathway, where the mean kinetic energy of a strongly stratified flow is extracted by primary unstable long waves and secondary short waves, and subsequently dissipated into internal energy.
Praxis, demonstration and pantomime: a motion capture investigation of differences in action performances
Authors: Żywiczyński Przemysław , Placiński Marek , Sibierska Marta , Boruta-Żywiczyńska Monika , Wacewicz Sławomir , Meina Michał , Gärdenfors Peter
Published: April 2024

A commonly held assumption is that demonstration and pantomime differ from ordinary action in that the movements are slowed down and exaggerated to be better understood by intended receivers. This claim has, however, been based on meagre empirical support. This article provides direct evidence that the different functional demands of demonstration and pantomime result in motion characteristics that differ from those for praxic action. In the experiment, participants were dressed in motion capture suits and asked to (1) perform an action, (2) demonstrate this action so that somebody else could learn how to perform it, (3) pantomime this action without using the object so that somebody else could learn how to perform it, and (4) pantomime this action without using the object so that somebody else could distinguish it from another action. The results confirm that actors slow down and exaggerate their movements in demonstrations and pantomimes when compared to ordinary actions.
Bringing “The Plant” to Life: Imagining Community Revitalization in the Neoliberal Era
Authors: Brown-Bernstein Julia
Published: April 2024

On August 27, 1992, the General Motors (GM) auto plant in Van Nuys closed after a half-century serving the Northeast San Fernando Valley. Its closure undercut the livelihoods of auto workers like Raymond Álvarez and his father Ramón. Today, the father and son duo look at “The Plant,” an outdoor shopping mall, and wonder whether the In-N-Out fast-food restaurant or T-Mobile store marks where they once stood on the assembly line. The departure of the GM plant and other long-standing manufacturing firms propelled the area into economic distress as Los Angeles was reeling from another crisis, the 1992 Uprising. In the wake of these events, elected officials clamored to revitalize the city. Six years later, “revitalization” came in the form of the shopping center, The Plant. By tracing the historical trajectory of one shuttered auto plant, from factory to shopping mall, this article demonstrates how neoliberal ideology gained legitimacy over the last several decades.
Molecular mechanisms of cytochrome P450-mediated detoxification of tetraniliprole, spinetoram, and emamectin benzoate in the fall armyworm, Spodoptera frugiperda (J.E. Smith)
Authors: Wang Aiyu , Zhang Yun , Liu Shaofang , Xue Chao , Zhao Yongxin , Zhao Ming , Yang Yuanxue , Zhang Jianhua
Published: April 2024

The fall armyworm (FAW) Spodoptera frugiperda (J.E. Smith) is a highly damaging invasive omnivorous pest that has developed varying degrees of resistance to commonly used insecticides. To investigate the molecular mechanisms of tolerance to tetraniliprole, spinetoram, and emamectin benzoate, the enzyme activity, synergistic effect, and RNA interference were implemented in S. frugiperda. The functions of cytochrome P450 monooxygenase (P450) in the tolerance to tetraniliprole, spinetoram, and emamectin benzoate in S. frugiperda was determined by analysing changes in detoxification metabolic enzyme activity and the effects of enzyme inhibitors on susceptibility to the three insecticides. 102 P450 genes were screened via transcriptome and genome, of which 67 P450 genes were differentially expressed in response to tetraniliprole, spinetoram, and emamectin benzoate and validated by quantitative real-time PCR. The expression patterns of CYP9A75, CYP340AA4, CYP340AX8v2, CYP340L16, CYP341B15v2, and CYP341B17v2 were analysed in different tissues and at different developmental stages in S. frugiperda. Silencing CYP340L16 significantly increased the susceptibility of S. frugiperda to tetraniliprole, spinetoram, and emamectin benzoate. Furthermore, knockdown of CYP340AX8v2, CYP9A75, and CYP341B17v2 significantly increased the sensitivity of S. frugiperda to tetraniliprole. Knockdown of CYP340AX8v2 and CYP340AA4 significantly increased mortality of S. frugiperda to spinetoram. Knockdown of CYP9A75 and CYP341B15v2 significantly increased the susceptibility of S. frugiperda to emamectin benzoate. These results may help to elucidate the mechanisms of tolerance to tetraniliprole, spinetoram and emamectin benzoate in S. frugiperda.
Disruption and localization of sediment pathways by continental extension: Detrital-zircon provenance change from upper Triassic to lower Jurassic in the northern Sverdrup Basin, Nunavut
Authors: Midwinter Derrick , Hadlari Thomas , Dewing Keith , Matthews William A
Published: April 2024

Constraints on the tectonic setting of the upper Triassic to lower Jurassic in the Sverdrup Basin can be elucidated from detrital-zircon U-Pb ages. During the Triassic, there was a dual provenance system into sedimentary basins along the western and northern margins of Laurentia. One of the sediment sources was from an extra-basinal igneous source of Permian-Triassic zircon while the other source was recycled sediment eroded from older sedimentary basins. The Heiberg Formation/Group was deposited during a period of significant siliciclastic sedimentation into the basin from the upper Triassic to the lower Jurassic and comprises three members: Romulus, Fosheim and Remus. Previous work has interpreted that the Carboniferous-Permian-Triassic detrital zircon had stopped reaching the northern part of the Sverdrup Basin by deposition of the upper Heiberg Formation (lower Jurassic). New detrital-zircon age analyses from samples along the northern part of the basin spanning different horizons in the Heiberg Formation show that the typical extra-basinal signature, with abundant Carboniferous-Permian-Triassic ages, was no longer recorded during the initial deposition of the Fosheim Member during the latest Triassic. Previously published basin analysis from the Sverdrup Basin interprets syn-Jurassic extensional faults and so we relate the provenance change to the onset of extension. It is interpreted that the Sverdrup Basin transitioned from a basin that received sediment from a northern extra-basinal igneous source during deposition of the Romulus Member to an extensional basin by the deposition of the Fosheim Member in the latest Triassic, as the northern sediment source was interrupted by intervening extensional basins of the proto-Amerasia Basin.
Theme-vowel minimal pairs show argument structure alternations
Authors: Kovačević Predrag , Milosavljević Stefan , Simonović Marko
Published: April 2024

This paper investigates correlations between theme vowels and argument structure in Serbo-Croatian. Specifically, we focus on two different theme vowels, -i- and -ova-, isolating ‘minimal pairs’, that is cases where the same base combines with the two theme vowels to derive different verbs. Starting from two online corpora of Serbo-Croatian, we created a comprehensive list of -i-/-ova- minimal pairs. For all pairs in the list whose both members were attested at least 50 times in the corpora, we randomly selected 50 tokens per verb and annotated them for transitivity. A statistical comparison of -i- and -ova- verbs according to the proportions of transitive uses was carried out. The findings show that -i- verbs are much more likely to be used transitively than -ova- verbs. This finding corroborates the view that theme vowels are associated with argument structure properties and challenges the idea that they are universally ‘ornamental’ pieces of morphology without syntactic/semantic import. Based on these and supplementary (non-corpus) data, we claim that -i- derives transitives and unaccusatives, while -ova- derives unergatives. We propose a model couched in Distributed Morphology whereby these two theme vowels are treated as instantiations of different ‘flavors of v’.
Meetings and minutes: Spaces of lawmaking and legal translation in colonial Indonesia
Authors: Ravensbergen Sanne
Published: April 2024

Central to this article are the minutes of nine codification meetings held in 1865 at various locations in West Sumatra. During these meetings the draft regulations for a new colonial legal system were discussed and negotiated by West Sumatran elites and Dutch officials. This episode and its unique archives serve as a microhistory of lawmaking, legal translation, and erasure. The article argues that the process of making colonialism procedural, as well as the genealogical workings of colonial knowledge production, are crucial to understanding the making and unmaking of law in the context of legal pluralities. It shows that finding similarities in interests and worldview, moments of ‘erasure through translation’, the symbolic language of fluidity of adat and legal hybridity, as well as the archival power of the material and the spatial elements of both the meetings and the minutes, were vehicles through which codification in West Sumatra was attempted and contested.
Associations between attention-deficit hyperactivity disorder genetic liability and ICD-10 medical conditions in adults: utilizing electronic health records in a Phenome-Wide Association Study
Authors: Haan Elis , Krebs Kristi , Võsa Urmo , Brikell Isabell , Larsson Henrik ,   Estonian Biobank Research Team, Lehto Kelli
Published: April 2024

Background

Attention-deficit hyperactivity disorder (ADHD) is often comorbid with other medical conditions in adult patients. However, ADHD is extremely underdiagnosed in adults and little is known about the medical comorbidities in undiagnosed adult individuals with high ADHD liability. In this study we investigated associations between ADHD genetic liability and electronic health record (EHR)-based ICD-10 diagnoses across all diagnostic categories, in individuals without ADHD diagnosis history.

Methods

We used data from the Estonian Biobank cohort (N = 111 261) and generated polygenic risk scores (PRS) for ADHD (PRSADHD) based on the ADHD genome-wide association study. We performed a phenome-wide association study (PheWAS) to test for associations between standardized PRSADHD and 1515 EHR-based ICD-10 diagnoses in the full and sex-stratified sample. We compared the observed significant ICD-10 associations to associations with (1) ADHD diagnosis and (2) questionnaire-based high ADHD risk analyses.

Results

After Bonferroni correction (p = 3.3 × 10−5) we identified 80 medical conditions associated with PRSADHD. The strongest evidence was seen with chronic obstructive pulmonary disease (OR 1.15, CI 1.11–1.18), obesity (OR 1.13, CI 1.11–1.15), and type 2 diabetes (OR 1.11, CI 1.09–1.14). Sex-stratified analysis generally showed similar associations in males and females. Out of all identified associations, 40% and 78% were also observed using ADHD diagnosis or questionnaire-based ADHD, respectively, as the predictor.

Conclusions

Overall our findings indicate that ADHD genetic liability is associated with an increased risk of a substantial number of medical conditions in undiagnosed individuals. These results highlight the need for timely detection and improved management of ADHD symptoms in adults.
The mediating role of reflective functioning and general psychopathology in the relationship between childhood conduct disorder and adult aggression among offenders
Authors: Yirmiya Karen , Constantinou Matthew , Simes Elizabeth , Bateman Anthony , Wason James , Yakeley Jessica , McMurran Mary , Crawford Mike , Frater Alison , Moran Paul , Barrett Barbara , Cameron Angus , Hoare Zoe , Allison Elizabeth , Pilling Stephen , Butler Stephen , Fonagy Peter
Published: April 2024

Background

The nature of the pathway from conduct disorder (CD) in adolescence to antisocial behavior in adulthood has been debated and the role of certain mediators remains unclear. One perspective is that CD forms part of a general psychopathology dimension, playing a central role in the developmental trajectory. Impairment in reflective functioning (RF), i.e., the capacity to understand one's own and others' mental states, may relate to CD, psychopathology, and aggression. Here, we characterized the structure of psychopathology in adult male-offenders and its role, along with RF, in mediating the relationship between CD in their adolescence and current aggression.

Methods

A secondary analysis of pre-treatment data from 313 probation-supervised offenders was conducted, and measures of CD symptoms, general and specific psychopathology factors, RF, and aggression were evaluated through clinical interviews and questionnaires.

Results

Confirmatory factor analyses indicated that a bifactor model best fitted the sample's psychopathology structure, including a general psychopathology factor (p factor) and five specific factors: internalizing, disinhibition, detachment, antagonism, and psychoticism. The structure of RF was fitted to the data using a one-factor model. According to our mediation model, CD significantly predicted the p factor, which was positively linked to RF impairments, resulting in increased aggression.

Conclusions

These findings highlight the critical role of a transdiagnostic approach provided by RF and general psychopathology in explaining the link between CD and aggression. Furthermore, they underscore the potential utility of treatments focusing on RF, such as mentalization-based treatment, in mitigating aggression in offenders with diverse psychopathologies.
Relative associations of behavioral and physiological risks for cardiometabolic disease with cognition in bipolar disorder during mid and later-life: findings from the UK biobank
Authors: Ringin Elysha , Dunstan David W. , Meyer Denny , McIntyre Roger S. , Owen Neville , Berk Michael , Hallgren Mats , Rossell Susan L. , Van Rheenen Tamsyn E.
Published: April 2024

Background

Cardiometabolic disease risk factors are disproportionately prevalent in bipolar disorder (BD) and are associated with cognitive impairment. It is, however, unknown which health risk factors for cardiometabolic disease are relevant to cognition in BD. This study aimed to identify the cardiometabolic disease risk factors that are the most important correlates of cognitive impairment in BD; and to examine whether the nature of the relationships vary between mid and later life.

Methods

Data from the UK Biobank were available for 966 participants with BD, aged between 40 and 69 years. Individual cardiometabolic disease risk factors were initially regressed onto a global cognition score in separate models for the following risk factor domains; (1) health risk behaviors (physical activity, sedentary behavior, smoking, and sleep) and (2) physiological risk factors, stratified into (2a) anthropometric and clinical risk (handgrip strength, body composition, and blood pressure), and (2b) cardiometabolic disease risk biomarkers (CRP, lipid profile, and HbA1c). A final combined multivariate regression model for global cognition was then fitted, including only the predictor variables that were significantly associated with cognition in the previous models.

Results

In the final combined model, lower mentally active and higher passive sedentary behavior, higher levels of physical activity, inadequate sleep duration, higher systolic and lower diastolic blood pressure, and lower handgrip strength were associated with worse global cognition.

Conclusions

Health risk behaviors, as well as blood pressure and muscular strength, are associated with cognitive function in BD, whereas other traditional physiological cardiometabolic disease risk factors are not.
Shared genetic basis and causality between schizophrenia and inflammatory bowel disease: evidence from a comprehensive genetic analysis
Authors: Wang Jing , Luo Guang-Yu , Tian Tian , Zhao Yu-Qiang , Meng Shi-Yin , Wu Jun-Hua , Han Wen-Xiu , Deng Bin , Ni Jing
Published: April 2024

Background

The comorbidity between schizophrenia (SCZ) and inflammatory bowel disease (IBD) observed in epidemiological studies is partially attributed to genetic overlap, but the magnitude of shared genetic components and the causality relationship between them remains unclear.

Methods

By leveraging large-scale genome-wide association study (GWAS) summary statistics for SCZ, IBD, ulcerative colitis (UC), and Crohn's disease (CD), we conducted a comprehensive genetic pleiotropic analysis to uncover shared loci, genes, or biological processes between SCZ and each of IBD, UC, and CD, independently. Univariable and multivariable Mendelian randomization (MR) analyses were applied to assess the causality across these two disorders.

Results

SCZ genetically correlated with IBD (rg = 0.14, p = 3.65 × 10−9), UC (rg = 0.15, p = 4.88 × 10−8), and CD (rg = 0.12, p = 2.27 × 10−6), all surpassed the Bonferroni correction. Cross-trait meta-analysis identified 64, 52, and 66 significantly independent loci associated with SCZ and IBD, UC, and CD, respectively. Follow-up gene-based analysis found 11 novel pleiotropic genes (KAT5, RABEP1, ELP5, CSNK1G1, etc) in all joint phenotypes. Co-expression and pathway enrichment analysis illustrated those novel genes were mainly involved in core immune-related signal transduction and cerebral disorder-related pathways. In univariable MR, genetic predisposition to SCZ was associated with an increased risk of IBD (OR 1.11, 95% CI 1.07–1.15, p = 1.85 × 10−6). Multivariable MR indicated a causal effect of genetic liability to SCZ on IBD risk independent of Actinobacteria (OR 1.11, 95% CI 1.06–1.16, p = 1.34 × 10−6) or BMI (OR 1.11, 95% CI 1.04–1.18, p = 1.84 × 10−3).

Conclusions

We confirmed a shared genetic basis, pleiotropic loci/genes, and causal relationship between SCZ and IBD, providing novel insights into the biological mechanism and therapeutic targets underlying these two disorders.
How do research participants with age-related vision loss talk about their experiences? A secondary discourse analysis of published qualitative extracts
Authors: Enoch Jamie , Subramanian Ahalya , Willig Carla
Published: April 2024

Age-related macular degeneration (AMD) is a chronic, progressive eye condition that can affect individuals in later life and lead to loss of central visual function. In this analysis, we aimed to explore the discursive landscape of talk about AMD, drawing on extracts published in peer-reviewed qualitative studies on AMD. Drawing on procedures of qualitative meta-synthesis, we compiled a corpus of raw data extracts from 25 qualitative studies on AMD published in English, largely carried out in high-income countries. Extracts were analysed to identify dominant discourses and key interpretative repertoires (such as recurring metaphors, tropes and figures of speech). We adopted a Foucauldian discourse analytic approach, to consider the implications of dominant discourses, and their associated subject positions, for the subjective experience of living with AMD. Our analysis identified five distinct ways in which AMD was constructed in research participants' talk about experiences of AMD. They included: AMD as a mysterious affliction, linked to biological ageing; AMD as a total loss of independence; AMD as grievous loss; AMD as a condition to be stoically accepted; and – to a more limited extent – AMD as an opportunity for discovery. Drawing on theory from critical disability studies and gerontology, we suggest that the constructions identified are underpinned by broader societal discourses which construct ageing and disability in largely negative, medicalised and individualistic terms. Taking up subject positions within such discourses may compound feelings of isolation, hopelessness and powerlessness. We suggest there may be value in exploring talk about experiences of living with AMD within a broader range of everyday social, relational and environmental contexts.
The Musicians’ Syndicate and the contradictions of state control over music in Egypt
Authors: Frankford Sophie
Published: April 2024

Based on 21 months of ethnographic fieldwork in Cairo with musicians who perform a musical style known as shaʿbi, this article unravels the complex role that the state-affiliated Musicians’ Syndicate plays in musicians’ working lives in order to investigate the contradictions of state control over music in Egypt. Focusing on moments of encounter between musicians and Syndicate officials, I consider why my interlocutors’ time was split between evading the Syndicate and its restrictions, and embracing the Syndicate by calling for it to implement harsher interventions. Doing so not only sheds light on the reality of cultural production in an authoritarian state, but also prompts a broader reconsideration of scholarly approaches to popular music censorship, requiring us to move beyond dichotomies of ‘state vs. society,’ ‘censors vs. censored,’ and ‘resistors vs. oppressors’ that have tended to dominate scholarship on music censorship.
A switched adaptive strategy for state estimation in MEMS-based inertial navigation systems with application for a flight test
Authors: Fadaki Mohammad Saber , Koofigar Hamid Reza , Ekramian Mohsen , Mortazavi Mahdi
Published: April 2024

This paper proposes a switched model to improve the estimation of Euler angles and decrease the inertial navigation system (INS) error, when the centrifugal acceleration occurs. Depending on the situation, one of the subsystems of the proposed switched model is activated for the estimation procedure. During global positioning system (GPS) outages, an extended Kalman filter (EKF) operates in the prediction mode and corrects the INS information, based on the system error model. Compared with previous works, the main advantages of the proposed switched-based adaptive EKF (SAEKF) method are (i) elimination of INS error, during the centrifugal acceleration, and (ii) high accuracy in estimating the attitude and positioning, particularly during GPS outages. To validate the efficiency of the proposed method in various trajectories, an experimental flight test is performed and discussed, involving a microelectromechanical (MEMS)-based INS. The comparative study shows that the proposed method considerably improves the accuracy in various scenarios.
New dawn in Mughal India: longue durée Neoplatonism in the making of Akbar's sun project
Authors: Gommans Jos , Huseini Said Reza
Published: April 2024

In this article, we explore the longue durée philosophical background of Mughal Emperor Akbar's sun worship. Although Akbar's sun project may have been triggered by contemporary Hindu and Zoroastrian ideas and practices, we argue that Akbar's Neoplatonic advisers reframed it as a universal cosmotheistic tradition that, at the start of the new millennium, served as the perfect all-inclusive imperial ideology of Akbar's new world order. The astonishing parallels with the much earlier Neoplatonic sun cult of Roman Emperor Julian demonstrate that, although having characteristic of its own, Akbar's sun project was not that unique and should be seen as a fascinating late example of a so-far completely forgotten ancient Neoplatonic legacy of seeing the philosopher king, via the Sun, via illumination, connected to the One.
Mobilising human resources to build a national communications network: the case of Japan before the Pacific War
Authors: Hunter Janet
Published: April 2024

This article analyses labour-intensive workforce strategies in Japan's government-run informational infrastructure (post, telegraph, and telephone) and in the adjunct services associated with their administration in the decades up to the Pacific War. It asks to what extent the growing scale of employment in Japan's communications infrastructure in this period confirms the existence of labour-intensive growth outside the manufacturing sector, and how far the growth of the labour force in post and telecommunications was facilitated by specific labour-absorbing institutions—that is, formal or informal institutions designed to mobilise or incentivise large numbers of employees. The discussion of these two associated questions shows not only that this area of infrastructure provision was highly labour-intensive in terms of the numbers employed and the diverse tasks undertaken, but also that the government-run postal system in effect depended for its growth and development on labour strategies and labour-absorbing institutions analogous to those usually associated with manufacturing development. The article also seeks to establish how far we can see in this sector the gradual improvement in the quality of labour normally associated with the labour-intensive industrialisation process, providing evidence that the evolving institutions were closely associated with a gradual improvement in the quality of labour and its ability to interact with rapidly changing needs and technologies.
Bankruptcy law as an alternative to fiscal policy in a Woodford model with a productivity shock
Authors: Araújo Aloísio , Costa Vitor
Published: April 2024

We show that trade credit contracts between sectors can provide a useful alternative to fiscal transfers during a major productivity shock. Defaults in credit contracts function as transfers between sectors, which can be implemented through a bankruptcy law or through credit renegotiation. Transfers implemented through defaults allow for a reduction in the size of the fiscal policy that restores the economy to the optimal allocation, constituting a relevant alternative to economies without an available fiscal space to implement the optimal policy.
Unit Testing in ASP Revisited: Language and Test-Driven Development Environment
Authors: AMENDOLA GIOVANNI , MAZZOTTA GIUSEPPE , RICCA FRANCESCO , BEREI TOBIAS
Published: April 2024

Unit testing frameworks are nowadays considered a best practice, included in almost all modern software development processes, to achieve rapid development of correct specifications. Knowledge representation and reasoning paradigms such as Answer Set Programming (ASP), that have been used in industry-level applications, are not an exception. Indeed, the first unit testing specification language for ASP was proposed in 2011 as a feature of the ASPIDE development environment. Later, a more portable unit testing language was included in the LANA annotation language. In this paper we revisit both languages and tools for unit testing in ASP. We propose a new unit test specification language that allows one to inline tests within ASP programs, and we identify the computational complexity of the tasks associated with checking the various program-correctness assertions. Test-case specifications are transparent to the traditional evaluation, but can be interpreted by a specific testing tool. Thus, we present a novel environment supporting test-driven development of ASP programs.
Christian democracy as political spirituality: transcendence as transformation—Italian politics, 1942–1953
Authors: Forlenza Rosario , Thomassen Bjørn
Published: April 2024

This article deals with the transformation of Catholic politics in Italy between 1942 and 1945 and the emergence of Christian Democracy as the dominant political party in the postwar years. It analyzes how Catholic politicians turned from reactionary critics of democracy to its champion. The article foregrounds a dimension that has not been given sufficient attention in scholarly works on political Catholicism and Christian Democracy, namely the religious content of thought. In the experiences of politicians and thinkers living through Fascism and war, transcendence and spirituality emerged as new markers of certainty that came to re-direct and ground democracy. Our conceptual argument is that Christian Democracy can be understood as a distinct form of “political spirituality,” pace Foucault. The article further shows how this political spirituality became “applied” in a series of ways in the immediate postwar period.
Bioinspired planar switched beam network using Butler matrix on a flexible substrate targeting multifaceted millimeter-wave applications
Authors: Biswas Balaka , Karmakar Ayan
Published: April 2024

This paper details the design and development of a planar switched beam network using 4 × 4 Butler matrix (BM) over a thin and flexible type biocompatible substrate. Four mils thick liquid crystal polymer (LCP) is used as a substrate here (ϵr = 2.92, tanδ = 0.002). The proposed design is centered at 28 GHz, targeting commercial millimeter-wave applications. Floral-shaped antenna with defective ground structures has been implemented as basic radiating elements. The whole structure is based on microstrip line configuration. The architecture occupies an area of 23.85 × 19.20 mm2 over the LCP substrate. Individual components of the BM are detailed here, followed by a system analysis of the whole integrated structure. The present work also covers the electrical equivalent circuit modeling of the whole beam-forming network. The fabricated prototype offers better than 18 dB return losses at each input port for the desired frequency band with 6 dBi (max.) peak gain and 500 MHz bandwidth around the center frequency. Port-to-port isolation of better than 15 dB is achieved with this topology. Experimental and simulated results are in good agreement in all aspects. A comparative study is also chalked out to highlight the significance of the current research work with respect to alike earlier reported structures.