bluuebunny/crossref_metadata_2025 huggingface dataset:
Multimodal Imaging of Severe Oxalate Retinopathy in a 20-Month-Old Boy
Authors: Aygün Figen Bezci , Kadayifcilar Sibel , Lotfi Sadigh Sepide , Ozaltin Fatih , Eldem Bora
Published: December 2022

Primary hyperoxaluria type 1 (PH1) is a rare disease due to alanine glyoxylate aminotransferase enzyme deficiency caused by mutations in AGXT gene. Increased oxalate causes crystalline deposits in the eye particularly in conjunctiva, cornea, iris, retina, and choroid. A 20-month-old boy was referred with a diagnosis of infantile PH1. There were numerous yellowish crystalline deposits at the posterior pole and hyperpigmented lesions were detected around the macula. Enhanced depth imaging optical coherence tomography (EDI-OCT) revealed dome-shaped retinal pigment epithelium elevations, subretinal and intraretinal hyperreflective material and also choroidal hyperreflective lesions. To the best of our knowledge, this is the first case to document choroidal deposition by EDI-OCT at such an early period of life.

[
Ophthalmic Surg Lasers Imaging Retina
2022;53:697–700.]
Topical Dexamethasone as an Adjuvant to Mineralocorticoid Receptor Antagonists for the Treatment of Recalcitrant Central Serous Chorioretinopathy
Authors: Wong Amanda , Zhu Daniel , Li Albert S. , Lee Jessica G. , Ferrone Philip J.
Published: December 2022

Background and Objective:

A previous report demonstrated efficacy of mineralocorticoid antagonist with adjuvant topical dexamethasone (MRA+DEX) in resolving subretinal fluid (SRF) in a chronic central serous chorioretinopathy (CSCR) patient. This pilot study investigates the use of MRA+DEX to treat recalcitrant, chronic CSCR patients.

Study Design:

Retrospective review of chronic, recalcitrant CSCR patients unresponsive to MRA alone who were treated with MRA+DEX and followed for up to 3 months. Apical SRF thickness and visual acuity were measured.

Results:

Ten eyes of eight chronic, recalcitrant patients were included with an average follow-up of 109 days. Mean percent reduction in apical fluid thickness at one month and at last follow-up after adding dexamethasone (DEX) was 33% and 52%, respectively. Five eyes (50%) achieved complete resolution of SRF. Three eyes (30%) showed partial response and two (20%) eyes had no response. There was no significant change in visual acuity.

Conclusions:

MRA+DEX decreased SRF in some recalcitrant, chronic CSCR patients. Large prospective studies are needed to evaluate the utility of MRA+DEX in these chronic CSCR patients.

[
Ophthalmic Surg Lasers Imaging Retina
2022;53:659–665.]
Variation in Perioperative Care Practices Among Vitreoretinal Surgeons in the United States
Authors: Finn Avni P. , Talcott Katherine E. , Han Jonathan , Ali Ferhina S. , Rao Prethy
Published: December 2022

Objective:

To describe perioperative practice patterns among retinal surgeons managing retinal detachment (RD) repair.

Methods:

This was a cross-sectional pilot survey of vitreoretinal surgeons in the United States (US), identified by a previously published web-based search and cross-referencing names from the American Society of Retina Specialists. Self-reported peri-operative practices and subgroups were analyzed.

Results:

Of the 298 surgical retina specialists who completed the survey, 115 (39%) were in practice for ≤ 5 years, 102 (34%) were in practice for 6 to 20 years, and 81 (27%) were in practice for > 20 years; 60%, 23%, and 16% were in private, academic, and hybrid practice, respectively. Fifty-nine percent reported operating with trainees. For ocular blocks, 59% perform retrobulbar, 21% peribulbar, and 20% subtenon's (ST). Use of ST block varied significantly by years in practice and presence of trainees (P< 0.0001,P= 0.004, respectively). Sixty percent perform primary scleral buckles (SB), 55% combined SB/pars plana vitrectomy (PPV), and 11% primary PPVs under general anesthesia. Use of general anesthesia for primary SB varied significantly by years in practice (P= 0.007). Surgeons with fewer years in practice were more likely to recommend facedown positioning for macula-off RDs (P< 0.0001). Forty-six percent of surgeons do not advise stopping blood thinners before surgery and this varied significantly by years in practice (P= 0.006).

Conclusions:

Variation exists among US vitreoretinal surgeons in relation to anesthesia, postoperative positioning, and blood thinners restrictions. Preferences are influenced by years in practice and less by trainees and practice setting. These results serve as a basis for larger, targeted US-based surveys on perioperative care and correlation with surgical outcomes.

[Ophthalmic Surg Lasers Imaging Retina2022;53:681–690.]
Multi-modal brain MRI images enhancement based on framelet and local weights super-resolution
Authors: Xu Yingying , Dai Songsong , Song Haifeng , Du Lei , Chen Ying
Published: December 2022

Magnetic resonance (MR) image enhancement technology can reconstruct high-resolution image from a low-resolution image, which is of great significance for clinical application and scientific research. T1 weighting and T2 weighting are the two common magnetic resonance imaging modes, each of which has its own advantages, but the imaging time of T2 is much longer than that of T1. Related studies have shown that they have very similar anatomical structures in brain images, which can be utilized to enhance the resolution of low-resolution T2 images by using the edge information of high-resolution T1 images that can be rapidly imaged, so as to shorten the imaging time needed for T2 images. In order to overcome the inflexibility of traditional methods using fixed weights for interpolation and the inaccuracy of using gradient threshold to determine edge regions, we propose a new model based on previous studies on multi-contrast MR image enhancement. Our model uses framelet decomposition to finely separate the edge structure of the T2 brain image, and uses the local regression weights calculated from T1 image to construct a global interpolation matrix, so that our model can not only guide the edge reconstruction more accurately where the weights are shared, but also carry out collaborative global optimization for the remaining pixels and their interpolated weights. Experimental results on a set of simulated MR data and two sets of real MR images show that the enhanced images obtained by the proposed method are superior to the compared methods in terms of visual sharpness or qualitative indicators.
Los judíos como expertos en prácticas terapéuticas en el mundo tardoantiguo: de la Enkoimesis y otras ritualidades mágicas
Authors: Torijano Pablo A. , Acerbi Silvia
Published: December 2022

Aunque se haya afirmado que el judaísmo conoció exclusivamente la incubatio en su variante más antigua, la mántico-adivinatoria, en nuestro trabajo intentamos ofrecer algunas reflexiones acerca del recurso a esta praxis con finalidades curativas en proximidad o en el interior de una sinagoga, circunstancia aludida por Juan Crisóstomo en un locus que ha pasado desapercibido o cuya exegesis por parte de los investigadores no resulta unívoca.
Semblanza de los doctores Mendoza y Carrillo. Dos judíos madrileños en el Túnez dieciochista
Authors: Álvarez Dopico Clara Ilham
Published: December 2022

A partir de los escritos del trinitario Francisco Ximénez y de la documentación de archivo De Propaganda Fide, se ofrece una semblanza de los doctores don Manuel de Gabriel Mendoza y don José Carrillo, que ejercieron como médicos en el Túnez de las primeras décadas del siglo XVIII. Sus biografías llaman nuestra atención sobre la existencia de una red de acogida de judaizantes llegados en fecha tardía desde la península ibérica a las costas africanas e ilustran cómo el común origen hispánico establece vínculos entre miembros de distintas comunidades religiosas, a la vez que crea redes sociales solidarias.
Problème d’identité épigraphique : fonction ou origo ?
Authors: Armani Sabine
Published: December 2022

Dans le cadre de ce travail1, nous envisagerons la question des identités à travers une étude de cas que fournit le réexamen d’une inscription de Mérida (AE, 1997, 781) qui mentionne l’affranchi [L. P]ostumius Apollonius, traditionnellement présenté comme un Augustal d’une cité de la province de Lusitanie, pour laquelle on hésite entre Norba (l’actuelle Cáceres) et Mérida, avec une préférence pour la seconde. L’étude est complétée par une réflexion sur le rayonnement du siège du gouverneur provincial dont le document est souvent présenté, à tort, comme un témoignage.
Provinciaux en Dacie, provinciaux de Dacie : enquête sur quelques expressions identitaires
Authors: Dana Dan
Published: December 2022

La Dacie romaine (106-ca. 260 ap. J.-C.), province intensément colonisée et militarisée, avec une visibilité réduite des populations indigènes, constitue un cas particulier de création d’une identité provinciale. Si les manifestations identitaires dans la province de Dacie sont difficilement décelables, elles sont, en revanche, plus visibles à l’extérieur de la province. La richesse de la documentation épigraphique et iconographique laissée par des personnes originaires de Dacie, essentiellement des militaires et des membres de leurs familles, permet de s’interroger sur les diverses expressions de leur identité provinciale (du type natione Dacus, par exemple) dans l’Empire romain.
Cyber-Physical Urban Mobility Systems
Authors: Samalna Dénis Awé , Ngossaha Justin Moskolai , Ari Ado Adamou Abba , Kolyang
Published: December 2022

Rapid population growth and the number of vehicles in cities have complicated urban mobility management. Digitalization supported by the internet of things and wireless communication has allowed some cities to mitigate the problem by taking advantage of the multiple benefits offered. These are cyber-physical systems (CPS), which are systems where a number of devices collaborate for the control of physical entities. This recent technology finds its application in urban mobility. However, in the context of developing countries, there are many local specificities one needs to consider. How could the integration of cyber-physical systems help urban decision makers to design sustainable urban mobility systems that meet the needs of the population? The paper proposed not only a recent review of the literature, but also a framework of CPS of urban mobility to guide decision makers. The challenges, opportunities, and barriers to innovation of CPS in urban environments in developing countries have also been identified.
Position Paper on Developing Standardized Modelling Approaches for the Management of Healthcare Organizations
Authors: Gerber Nicole
Published: December 2022

Healthcare organisations are continually forced to rethink and redesign their processes and procedures due to internal and external requirements and occurrences. The best way to test new procedures would be through real-life experiments and/or simulations based on real-time data. However, experiments are only rarely possible in a service provision environment which is highly complex and safety and security driven, and so data are sometimes not available in the required quantity (yet). The application of models provides an alternative. However, to serve as a solid foundation, such models need to fulfil certain criteria: they need to be consistent, complete, accurate, and without redundancies, and they also have to provide the basis for a common understanding for stakeholders from different backgrounds, thereby making it possible to choose from multiple perspectives.
Optimization of CO2 Laser Parameters for Hole Micro Drilling of PMMA: An Experimental and Theoretical Study
Authors: Abdulwahab Ansam Essa , Hubeatir Kadhim Abd , Imhan Khalil Ibrahim
Published: December 2022

Motivated by a desire to improve hole quality during drilling Polymethyl methacrylate (PMMA) samples using a continuous CO2 laser. This research presents a theoretical and experimental investigation to optimize input parameters of laser drilling such as laser power and exposure time for different thicknesses 1-3 (mm). Hole quality characteristics such as depth, inlet diameter, and heat affected zone (HAZ) were considered process results and examined with a microscope. Design Expert software has been used to get a detailed understanding of a laser drilling process owing to the confluence of multiple factors that impacts the results. depending on the Box Behnken Design (BBD) of tests software; 17 experiments were applied to explore the effect of laser factors on the micro-hole drilling process. Statistical analysis technique (ANOVA) was used to study the influence of laser drilling process factors including power, exposure time of different thicknesses on HAZ, depth, and entrance diameter. Quadratic regression models were employed to model the processing of many hole variables. Experiments were optimized using the defined goal model as a function to get the optimal hole. The data received were confirmed using verification tests, and a considerable increase in hole quality was realized. The proposed technique is perfect for reducing the HAZ and entrance hole diameter for the ideal depth hole. The laser parameters were changed in different combinations of 2-6 (W) power and 0.1- 0.3 (s) exposure duration, on the various thickness. The obtained values indicated that raising the drilling parameters increases the depth, entrance diameter, and HAZ. The sample thickness has a great impact on hole characteristics; increasing the sample thickness reduces the inlet diameter, and heat-affected zone (HAZ); increasing the thickness leads to an increase in hole depth. The results showed that the highest depth of 1mm thick was 0.99(mm) with 437(µm) diameter and 85(µm) HAZ. 1.9(mm) depth with 435(µm) diameter and 32(µm) HAZ was obtained at 4.99(W) and 0.1(s) on 2(mm) thickness. while as in 3(mm) thick, depth is equal to 2.8(mm), 472(µm) diameter, and 20(µm) HAZ was attained. COMSOL Multiphysics 5.6 software was used to apply virtual experiments and obtain the ideal conditions from the parameters' combination that improves the quality of the hole, which is the main goal of this research. Which is in good agreement with the test results. The findings and procedure of this research have not been presented elsewhere.
The Physical-Mechanical Properties in Aggressive Media of Epoxy Composite Reinforced with Waste Glass Materials
Authors: Kadhim Hadeel I. , Fahad Besma M. , Hameed Awham M.
Published: December 2022

The world is evolving toward extending the life of commodities and decreasing waste by recycling. The purpose of this study is to improve resistance of epoxy against the corrosive conditions by reinforcing it with available chemically resistant and low cost materials. Selection of Glass wastes to reinforce epoxy with 50% by weight. Preparation of four sets of samples for this purpose, two sets of samples make and cure at room temperature, while the others cure at 50°C for two hours. Each set make up of both reinforced and unreinforced epoxy. Immersion of these samples in different environment (Water, NaOH, HCl, Benzene and Kerosene) to find out the resistance of the epoxy after reinforcing. After immersion for six months, it is found that the composite seems more resistance compared to matrix material alone. Composites reinforced by glass particles show an increase in mechanical properties when compared to elegant epoxy resin. Density, Vickers hardness and Modulus of elasticity values increased by (31%, 67% and 62%) respectively for composite at room temperature. Improvement of the resistance after the post curing of unreinforced and reinforced epoxy. The solutions that have highest effect for unreinforced samples at room temperature are (HCl and Water). This indicates that epoxy acquire resistance after reinforcing with glass waste which enables it to be utilize in different applications.
The Influence of Thermo Mechanical Treatment on Corrosion Resistance of Cu-Al-Ni Shape Memory Alloy
Authors: Dawood Haider Adnan , Adnan Raad Suhail Ahmed
Published: December 2022

In This Study that includes the thermal treatment with mechanical in compression at constant loading of 30 KN Was investigated by using the three Different temperature at (260-280-300)°C for Cu-14%Al-4.5Ni then Potentiondynamics polarization tests were applied to the Alloys with Microstructure by Scanning Electron Microscope SEM results shows an decrease in corrosion rates and increasing in corrosion resistance with the Increase of working temperature.
Conductivity and Dielectric Study of Polylactic Acid- Lithium Perchlorate Solid Polymer Electrolyte Film
Authors: Lothfy Fairuzdzah Ahmad , Marwan Bin Ali Abdul Malik , Rafaie Hartini Ahmad , Hassan Muhammad Syafiq , Abidin Siti Zafirah Zainal
Published: December 2022

The solid polymer electrolyte (SPE) consists of polylactic acid (PLA) with different compositions of lithium perchlorate (LiClO4) were prepared by using the solution casting method. The conductivity and dielectric properties of the SPE system were studied by using an impedance spectroscopy technique with a frequency ranging from 0.1 Hz to 100 MHz. The optimum composition of the LiClO4 in the PLA based electrolyte system is 50 %. The highest ionic conductivity value of the PLA-LiClO4 electrolyte is 2.66 x 10-5 Scm-1. The dielectric permittivity, ɛ′ shows high magnitude in the lower frequency due to electrode polarization (EP) effect and become to decrease at high frequency. The magnitude of ɛ′ increases up to 50 % of LiClO4 in the electrolyte system. The loss tangent was used to measure the relaxation time of the electrolyte system. The shortest relaxation time is PLA- LiClO4 polymer electrolyte system is 7.98 × 10−6 s. The electric modulus, M′ and M′', increases with frequency, indicating that the force of charge carriers increases in depletion and accumulation regions at room temperature.
Effect of Multi-Walled Carbon Nanotubes (MWCNTs) in Reducing the Corrosion Rate in Cr-MWCNTs Composite Coatings
Authors: Dawood Nawal Mohammed , Nattah Ayad Mohammed , Jasim Talib Abdulameer
Published: December 2022

Carbon steel was coated with Cr-multi-walled carbon nanotube (MWCNTs) coatings via electrodeposition. In this article, the impact of a combination of MWCNTs into the chromium coating on the morphology of the coating surface and corrosion characteristics was inspected. The MWCNTs seem to be evenly distributed across the chromium layer, according to scanning electron microscopy (SEM). Electrochemical measurements were used to conduct corrosion tests on samples of MWCNTs– chromium composite coated and pure chromium coated samples in aqueous NaCl (3.5 wt.%). The outcomes demonstrated a considerable increase in the resistance of corrosion due to the inclusion of MWCNTs during the chromium deposition procedure. In addition, the mechanism of anti-corrosion of the composite coating is also presented. Using an electrolyte bath containing various concentrations of dispersed MWCNTs (0.5, 1, and 1.5 g/L), crack-free and compact coating of Cr-MWCNT composite were electrodeposited on the substrates of the mild steel. The potentiodynamic polarization technique was used to examine the coatings corrosion performance subjected to a 3.5 weight percent of NaCl medium. When compared to chromium coating, the Cr-MWCNT composite coating showed the lowest corrosion rate (1.045x108mpy) compared to chromium coating (4.891x108mpy).
Electrical Properties of Jackfruit Seed Starch and Polyvinyl Alcohol Blend with Different Composition of Zinc Oxide
Authors: Ramli Raihan , Lothfy Fairuzdzah Ahmad , Marwan Bin Ali Abdul Malik , Mohd Nor Asiah
Published: December 2022

A biopolymer electrolyte made from natural polymer consists of jackfruit seed starch (JSS) and polyvinyl alcohol (PVA) with a different composition of zinc oxide (ZnO) was prepared using the solution casting method. The incorporation of metal oxides such as ZnO into natural polymers can improve the electrical properties, which can produce biodegradable energy storage devices. This innovation may aid in the reduction of the use of electronic devices, which generate e-waste. Thus, this study was conducted to investigate the effect of ZnO addition to the biopolymer in terms of its electrical properties. The samples were prepared by using the solution casting method. Different percentages of ZnO were mixed with JSS, PVA, hydrocloric acid, sodium hydroxide, and glycerol before being moulded in a petri dish and dried at room temperature. The electrical properties of the blends were then characterized by using an Agilent 4284a Precision LCR meter. The highest ionic conductivity value for JSS and PVA after the addition of ZnO is 1.10x10-6 Scm-1 with 10% of ZnO, and the lowest conductivity is 2.11x10-7 Scm-1 with 14% of ZnO. The dielectric and electric modulus were further studied in order to understand the electrode polarization effect.
The Biomedical Investigation of Bioceramic Cordierite as Orthopedic Material
Authors: Basheet Mohammad Hasan , Farhan Fadhil Kareem , Abed Abdulrahman  N. , Alobaidi Omar R.
Published: December 2022

This study focused on the production of bioactive pure cordierite ceramic and the evaluation of its bioactivity by immersing it in simulated bodily fluid (SBF) and coating it on CP-Ti utilizing the dip coating Procedure. Cordierite is created by chemical coprecipitation, which involves combining Cordierite gel with a water-based sol-gel composed of Alumina Al2O3, magnesium oxide MgO, and silicon oxide SiO2. They used a hydraulic press to form cordierite into a cylindrical shape with a pressure of 4 bar and a holding time of 30 minutes at this pressure. Firing presses reach temperatures of 1250 Co and have a holding time of 2 hours. A Field Emission Scanning Electron Microscope (FESEM) was used to examine the microstructure, which revealed a homogenous distribution of the compounds with negligible porosities. The phase transitions that cur during the sintering Process is studied using X-ray diffraction (XRD). The structural investigation of specimens revealed the formation of the cordierite phase at 1250 Co, as well as the development of cristobalite, spinel, protoestatite, and corundum with cordierite phase. The dip coating Procedure was utilized to cover commercial pure titanium (CP-Ti) samples with cordierite powder. CP and Tafel exploration tests show that coated CP-Ti has superior passivation than uncoated Substrate. By comparing the findings of uncoated and coated CP-Ti, this paper concludes that the cordierite system acts as a good passivation layer.
Heat Treatment of Multi-Material Additively Manufactured Maraging Steel and Co-Cr-Mo Alloy
Authors: Pasco Jubert , Tian Yuan , Chadha Kanwal , Aranas Jr. Clodualdo
Published: December 2022

The prospect of converting an entire assembly of parts with challenging geometry to a single part with sectional variation of properties has stimulated a growing interest in multi-material Additive Manufacturing (AM). Accordingly, the present work utilized a dual-metal Laser Powder Bed Fusion (LPBF) technique to manufacture a multi-material component, consisting of Co-Cr-Mo alloy (MP1) and maraging steel (MS1) in a single manufacturing process. The research also attempted to establish a heat treatment strategy compatible with these alloys. The resulting heat treatment effects on the microstructure, texture, and microhardness were investigated. Diffusion calculation results suggested an overall diffusion depth of 120 μm in the interface after heat treatment, which can increase the resulting joint strength if intermetallic precipitation is avoided. Electron Backscatter Diffraction (EBSD) analysis of the heat-treated samples showed that both the base metal regions retained the dominant fiber textures after printing, which is the <110> || building direction (BD) fiber texture for the MP1 region and the <111> || BD and <100> || BD fiber textures for the MS1 region. Nanoindentation tests also revealed a considerably higher hardness in the MS1 region and a slight reduction of hardness in the MP1 region after heat treatment, which can be early evidence of the successful application of the heat treatment strategy to both base metals. Future work will investigate the mechanical properties of the as-printed and heat-treated samples and verify if any precipitates formed in the MS1-MP1 interface.
Study of Microstructural and Mechanical Properties of Ti-Alloys Synthesis from High Energy Ball Milling by Spark Plasma Sintering - A Review
Authors: Pushp Pallavi , Dasharath S.M.
Published: December 2022

Titanium and its alloys are attractive engineering materials used in aerospace, automotive, biomedical, and marine industry because of their outstanding mechanical properties such as high specific strength and physical properties with excellent corrosion resistance and excellent elevated temperature properties. This paper presents a brief review on the The effects of ball-milling time on the microstructure and mechanical properties of the ball-milled powder and sintered compact were investigated. As-milled powders and sintered Ti-Alloys samples were evaluated by X-ray diffraction, scanning electron microscopy, energy dispersive spectrometry, laser diffraction particle size analysis, and transmission electron microscopy.
An ex vivo experimental system to track fluorescent nanoparticles inside skeletal muscle
Authors: Calderan Laura , Carton Flavia , Andreana Ilaria , Bincoletto Valeria , Arpicco Silvia , Stella Barbara , Malatesta Manuela
Published: December 2022

The development of novel nanoconstructs for biomedical applications requires the assessment of their biodistribution, metabolism and clearance in single cells, organs and entire organisms in a living environment. To reduce the number of in vivo experiments performed and to refine the methods used, in accordance with the 3Rs principle, this work proposes an ex vivo experimental system to monitor, using fluorescence microscopy, the distribution of nanoparticles in explanted murine skeletal muscle maintained in a bioreactor that can preserve the structural and functional features of the organ for long periods of time. Fluorescently-labelled liposomes and poly(lactide-co-glycolide) (PLGA)-based nanoparticles were injected into the intact soleus muscle (in the distal region close to the tendon) immediately after explants, and their distribution was analysed at increasing incubation times in cross cryosections from the proximal region of the belly. Both nanocarriers were clearly recognized in the muscle and were found to enter and migrate inside the myofibres, whereas their migration in the connective tissue seemed to be limited. In addition, some fluorescent signals were observed inside the macrophages, demonstrating the physiological clearance of the nanocarriers that did not enter the myofibres. Our ex vivo system therefore provides more information than previous in vitro experiments on cultured muscle cells, highlighting the need for the appropriate functionalization of nanocarriers if myofibre targeting is to be improved.
Evaluation of errors during susceptibility reporting of glycopeptide antibiotics for enterococcal isolates on sole basis of widely used disk diffusion test
Authors: Saini Vikas , Goyal Nisha , Singh Narendra Pal , Goswami Meenakshi
Published: December 2022

In resource limited settings, very often susceptibility reports glycopeptide antibiotics are released only on the basis of disk diffusion test. Determination of MIC by either E-strips or microbroth dilution tests can be of paramount importance in checking the errors that may have incurred with the singular use of disk diffusion tests. Distribution of errors in Vancomycin and Teicoplanin susceptibility reporting by disk diffusion test was evaluated in comparison with MIC determination with reference method of E-strip. A total of 40 isolates of Enterococcus species were obtained during the study period. In vancomycin susceptibility reporting, very major errors, major errors and minor errors were observed in 33.3%, 5.4% and 5% instances respectively. For teicoplanin, major errors were observed in 5.3% of instances. E test can be used in conjunction with disk diffusion where resources are limited. We have observed that by using a combination of both disk diffusion and MIC determination by E-strip methods for glycopeptide antibiotics, a majority of reporting errors can be addressed.
Studio di valutazione del presidio Rigenoma con ozoile nel trattamento di lesioni cutanee croniche
Authors: Ricci Elia , Pittarello Monica , Giacinto Francesco
Published: December 2022

L’ozono è utilizzato per fini medici sin dall’800 e da anni anche per il trattamento delle lesioni cutanee. Le proprietà di questa molecola sono molteplici, tra cui aumento della disponibilità di O2, antinfiammatorie ed antisettiche. Abbiamo testato la perfomance di un presidio a base di Ozoile (Ozonidi stabili da olio di oliva biologico), nel trattamento di lesioni cutanee croniche. Sono stati reclutati 40 pazienti con lesioni di diversa etiologia e localizzazioni alla gamba o al piede. I parametri analizzati sono stati: area, infezione, dolore, WBP ed insorgenza di eventi avversi. Lo studio, osservazionale, prevedeva un run in di arruolamento ed osservazione di 2 settimane ed un periodo di trattamento con Ozoile di 6 settimane. I dati raccolti hanno evidenziato una ottima performance del presidio utilizzato su tutti i parametri. Gli stessi dati, analizzati con il test lineare di ANOVA, hanno evidenziato una significatività della p su area, dolore ed insorgenza di infezioni. Gli autori ritengono che detti risultati confermino le ipotesi, riportate in letteratura, sulle attività dell’ozono e dei suoi derivati.
Seismic hazard investigations at select DND facilities in Southwestern British Columbia: subduction, in-slab, and crustal scenarios
Authors: Paul C , Cassidy J F
Published: December 2022

Southwest British Columbia has some of the highest seismic hazard in Canada and is home to facilities owned by the Department of National Defence which support operations on the west coast of Canada. The potential impact of seismic hazards on these government
facilities are investigated here. The hazard is from three primary sources: subduction interface, crustal and in-slab earthquakes. NRCan, in consultation with DRDC have produced representative earthquake scenarios for each of these sources. The subduction scenario we constructed was an M8.9
earthquake extending along the entire Cascadia Subduction Zone from 4 to 18 km depth. We used an M6.8 earthquake occurring along a 30 km fault at between 52 and 60 km depth below Boundary Bay to represent in-slab events. The final scenario, representing a crustal source, was an M6.4 along the
central 47 km of the Leech River Valley-Devil's Mountain Fault system. We found that the Cascadia subduction scenario dominated the shaking hazard over much of the study region. Meanwhile, the in-slab and crustal scenarios have higher but more localized hazards in Vancouver and Victoria. In addition
to the primary ground motion hazard, we also examined secondary seismic hazards: secondary amplification effects, landslides, liquefaction, surface ruptures, tsunami, flooding, fire, and aftershocks. Each of the secondary hazards had varying impacts depending on the scenario and locations within the
region.
Association between circular stapler size and anastomotic leakage after laparoscopic low anterior resection for rectal cancer
Authors: Jiang Yugang , Chen Hongyuan , Kong Meng , Sun Dong , Sheng Hongguang
Published: December 2022

Background:

Anastomotic leakage (AL) is one of the most severe and frequent complications occurring after laparoscopic low anterior resection (LAR) for rectal cancer. This study aimed to examine the association between circular stapler size and AL after laparoscopic LAR.

Methods:

This retrospective single-institution study involved 181 patients with rectal cancer who underwent laparoscopic LAR performed by a single surgical team between July 2016 and June 2021. The characteristics of the patients were analyzed. Risk factors for AL were identified via univariate and multivariate analyses. Additionally, a further propensity score matching (PSM) analysis was performed to reduce the selection bias.

Results:

Among the 181 patients who underwent laparoscopic LAR for rectal cancer, 17 (9.4%) developed clinical AL. In the univariate and multivariate analyses, male sex, incomplete intestinal obstruction, and the usage of a 32-mm stapler during the surgery were independent risk factors for the occurrence of AL. Furthermore, the PSM analysis confirmed that the incidence of AL with a 32-mm stapler was higher than that with a 29-mm stapler after laparoscopic low anterior resection. However, there was no difference in the incidence of anastomotic bleeding and stenosis.

Conclusion:

Choosing a smaller-diameter circular stapler may reduce the incidence of AL after laparoscopic LARfor rectal cancer without increasing the incidence of anastomotic stenosis.
A New Insight on Feasibility of Pre-, Pro-, and Synbiotics-based Therapies in Alzheimer’s Disease
Authors: Talebi Marjan , Ebrahimi Vida , Rasouli Ahmadreza , Farjami Afasneh , Razi Soofiyani Saiedeh , Soleimanian Alireza , Forouhandeh Haleh , Tarhriz Vahideh
Published: December 2022

Alzheimer’s disease is a prevalent cause of dementia in the elderly population. The existing treatments in this issue are limited in efficacy besides having several adverse effects. Therefore, developing new therapeutic strategies is a major concern of scientists. This disease is closely linked to gut microflora through the brain–gut–microbiota axis. Targeting gut microbiota by pre-, pro-, and synbiotics supplementation can be effective for its treatment. Herein, we discuss the protecting effects of pre-, pro-, and synbiotics products against Alzheimer’s disease based on comprehensive assessment of animal studies and performed clinical trials. Primarily, we briefly introduced involved pathogenesis, probable drug targets, and its correlation with gut microbiota. Subsequently, we debated preclinical and clinical research studies on the effect of pre-, pro-, and synbiotics agents on brain functionality, metabolic features, and biomarkers that are proven to have therapeutic effects. Searching the online databases revealed therapeutic capabilities of pre-, pro-, and synbiotics in Alzheimer’s disease treatment by some mechanisms such as anti-oxidative stress, anti-inflammatory, prohibiting of apoptosis and DNA damage, insulin regulation, suppressing the aggregation of beta-amyloid (Aβ) and tau proteins, which can be considered as important outcomes of this application.
On the boundaries of the $m=2$ amplituhedron
Authors: Łukowski Tomasz
Published: December 2022

Amplituhedra

\mathcal{A}_{n,k}^{(m)}

are geometric objects of great interest in modern mathematics and physics: for mathematicians, they are combinatorially rich generalizations of polygons and polytopes, based on the notion of positivity; for physicists, the amplituhedron

\mathcal{A}^{(4)}_{n,k}

encodes the scattering amplitudes of the planar

\mathcal{N}=4

super Yang–Mills theory. In this paper, we study the structure of boundaries for the amplituhedron

\mathcal{A}_{n,k}^{(2)}

. We classify all boundaries of all dimensions and provide their graphical enumeration. We find that the boundary poset for the amplituhedron is Eulerian and show that the Euler characteristic of the amplituhedron equals one. This provides an initial step towards proving that the amplituhedron for

m=2

is homeomorphic to a closed ball.
Monotonicity and phase transition for the VRJP and the ERRW
Authors: Poudevigne-Auboiron Rémy
Published: December 2022

The vertex-reinforced jump process (VRJP), introduced by Davis and Volkov, is a continuous-time process that tends to come back to already visited vertices. It is closely linked to the edge-reinforced random walk (ERRW) introduced by Coppersmith and Diaconis in 1986 which is more likely to traverse edges it has already traversed. On

\mathbb{Z}^d

for

d\geq 3

, both models were shown to be recurrent for small enough initial weights and transient for large enough initial weights. We show through a coupling of VRJPs for different weights that the VRJP (and the ERRW) exhibits some monotonicity. In particular, we show that increasing the initial weights of the VRJP and the ERRW makes them more transient, which means that the recurrence/transience phase transition is necessarily unique. Furthermore, by making the weights go to infinity, we show that the recurrence of the ERRW and the VRJP is implied by the recurrence of a random walk in a deterministic electrical network.
On polynomial-time computation of high-dimensional posterior measures by Langevin-type algorithms
Authors: Nickl Richard , Wang Sven
Published: December 2022

The problem of generating random samples of high-dimensional posterior distributions is considered. The main results consist of non-asymptotic computational guarantees for Langevin-type MCMC algorithms which scale polynomially in key quantities such as the dimension of the model, the desired precision level, and the number of available statistical measurements. As a direct consequence, it is shown that posterior mean vectors as well as optimisation based maximum a posteriori (MAP) estimates are computable in polynomial time, with high probability under the distribution of the data. These results are complemented by statistical guarantees for recovery of the ground truth parameter generating the data.

Our results are derived in a general high-dimensional non-linear regression setting (with Gaussian process priors) where posterior measures are not necessarily log-concave, employing a set of local ‘geometric’ assumptions on the parameter space, and assuming that a good initialiser of the algorithm is available. The theory is applied to a representative non-linear example from PDEs involving a steady-state Schrödinger equation.
Extremal mappings of finite distortion and the Radon–Riesz property
Authors: Martin Gaven J. , Yao Cong
Published: December 2022

We consider Sobolev mappings

f\in W^{1,q}(\Omega,\mathbb{C})

,

1<q<\infty

, between planar domains

\Omega\subset \mathbb{C}

. We analyse the Radon–Riesz property for polyconvex functionals of the form

f\mapsto \int_\Omega \Phi(|Df(z)|,J(z,f)) \, dz

and show that under certain criteria, which hold in important cases, weak convergence in

W_{\mathrm{loc}}^{1,q}(\Omega)

of (for instance) a minimising sequence can be improved to strong convergence. This finds important applications in the minimisation problems for mappings of finite distortion and the

L^p

and Exp-Teichmüller theories.
Multiresidue chromatographic method for the determination of antibiotic residues in honey by high-performance liquid chromatography with DAD detection
Authors: RACHİD Bouchra , JABER Ali , CHEBLE Edmond
Published: December 2022

Clandestinely, consumers may be exposed to antibiotic (ATB) residues in honey, which could pose a health concern. For the first time, the simultaneous determination of Florfenicol (FF), Penicillin G (PG), and Tetracycline is described in this paper. The multiresidual method was developed and optimized using high-performance liquid chromatography (HPLC) coupled to a diode array detector (DAD). These ATBs were separated on a C18 analytical column after a cleanup process followed by solid-phase extraction (SPE). For the first time, the chromatographic conditions were perfected. After the method validation process, the method was used to assess ATB residues in four Lebanese honey samples. ATBs were separated in less than 15 min with an isocratic elution using a mixture of 80 % potassium dihydrogen phosphate aqueous solution, and 20 % acetonitrile. The UV detection was performed at 350 nm for TC, 224 nm for FF, and 230 nm for PG. The proposed method was linear (R2 ≥ 0.996) within the concentration ranges of 0.7-17.5 mg.Kg 1 for the three compounds. Both intra- and inter-day precision, expressed as RSD, were ≤15 %. The method was subsequently successfully applied to analyze examined ATB residues in honey samples collected from Lebanese beekeeping. The method described could be a valuable tool to conduct a comprehensive survey of honey samples produced in Lebanon, especially in the lack of serious national oversight.
sociologia
Authors: Lima Jacob Carlos
Published: December 2022

Desde sua origem a sociologia enfrenta desafios acerca de sua legitimação enquanto conhecimento científico e acadêmico. É constantemente desafiada a demonstrar sua relevância e utilidade. Por ter como objetivo compreender as relações sociais, desvendando o aparente e recuperando o não visível nas estruturas sociais, incomoda pelo que revela. Por não ser uma ciência normativa, é questionada em sua utilidade. Neste artigo recupero historicamente alguns momentos desse debate, centrando na sociologia brasileira, sua institucionalização e expansão, os ataques que vem recebendo mais recentemente pelo poder público, e os desafios enfrentados no quadro pandêmico que estamos vivendo.
Carreau Akışkanının Dikey Germe Silindirindeki Akış Karakteristiklerinin Yapay Zeka Yaklaşımıyla Analizi
Authors: ÇOLAK Andaç Batur
Published: December 2022

Bu çalışmada, Carreau akışkan akışının gözenekli bir ortama daldırılmış dikey bir germe silindiri üzerindeki akış karakteristikleri, yapay zeka yaklaşımı ile detaylı olarak analiz edilmiştir. Akış parametreleri olarak lokal yüzey sürtünmesi, lokal Nusselt sayısı ve lokal Sherwood sayısı parametreleri ele alınmıştır. Akış parametrelerini tahmin etmek için çok katmanlı algılayıcı mimarisine sahip üç farklı yapay sinir ağı modeli tasarlanmıştır. Literatürden elde edilmiş nümerik veri seti kullanılarak eğitilmiş olan ağ modellerinde Bayesian Düzenlileştirme eğitim algoritması kullanılmıştır. Farklı performans parametreleri dikkate alınarak optimize edilen yapay sinir ağlarında tahmin performansı en yüksek olan modeller tercih edilmiştir. Elde edilen tahmini değerler, hedef verilerle karşılaştırılmıştır. Ayrıca performans parametreleri de hesaplanmış ve ağ modellerinin performansları kapsamlı bir şekilde analiz edilmiştir. Çalışma bulguları, geliştirilmiş olan yapay sinir ağlarının, doğal taşınımlı Carreau akışına ait parametreleri yüksek doğrulukta tahmin edebildiğini ortaya koymuştur.
Politological Dimension of Wars and Military Conflicts
Authors: Sherhin Serhii
Published: December 2022

In the article the wars and conflicts are classified in terms of political science theory. The main attention is paid to paradigmal and conceptual interpretation of contemporary military conflicts in the international relations. These aspects of origins of conflicts and wars have been reflected in classic political science and postmodern concepts authors of which primarily are foreign scientists. Actually, all of them despite of their belonging to the different academic schools recognize states as the main subjects of military conflicts. Moreover, classification of wars and conflicts continues to be the main point in political science. Central point of political researches is a question of ways and means of regulating international conflicts. In this context the problem of transformation of local and regional conflicts in a full-scale (global) war is of special research significance. Emergence of nongovernmental subjects of world politics and new forms of wars caused the necessity to take correctives in analyses of these phenomena. Nevertheless, objective reasons of military conflicts as well as factors and possibilities of their transformation into full-scale wars don’t depend on the postulates of politology.
THE ROLE OF THE INTERNATIONAL CRIMINAL COURT IN ENSURING PEACE AND SECURITY
Authors: Mukomela Tetiana
Published: December 2022

Recent changes in the field of international law objectively require an adequate response from the international community to prevent violations of inalienable human and national rights, and a swift and sustained response to the commission of international crimes. Due to the unprecedented scale of international crime, it is necessary for states to join forces and establish cooperation in this area. Therefore, this topic is quite relevant, as the activities of the International Criminal Court affect the maintenance of international peace and security. Recent changes in the field of international law objectively require an adequate response from the international community to prevent violations of inalienable human and national rights, and a swift and sustained response to the commission of international crimes. Due to the unprecedented scale of international crime, it is necessary for states to join forces and establish cooperation in this area. Therefore, this topic is quite relevant, as the activities of the International Criminal Court affect the maintenance of international peace and security. Recent changes in the field of international law objectively require an adequate response from the international community to prevent violations of inalienable human and national rights, and a swift and sustained response to the commission of international crimes. Due to the unprecedented scale of international crime, it is necessary for states to join forces and establish cooperation in this area. Therefore, this topic is quite relevant, as the activities of the International Criminal Court affect the maintenance of international peace and security. Due to the unprecedented scale of international crime, it is necessary for states to join forces and establish cooperation in this area. Therefore, this topic is quite relevant, as the activities of the International Criminal Court affect the maintenance of international peace and security.
PARTNERSHIP AND CONTRADICTION OF RELATIONS BETWEEN UKRAINE AND HUNGARY
Authors: Kondratenko Oleh
Published: December 2022

The essence and prospects of Ukraine 's foreign policy in the conditions of the crisis of the transitive world order in the Eastern European context are revealed. The countries of Central and Eastern Europe actively support Ukraine in its policy of integration into European and Euro-Atlantic structures. At the same time, the range of threats to Ukraine's national security arising from Eastern European countries, which inflate the situation around the historical and cultural heritage and oppression of Ukraine by their national minorities, should not be ruled out. Hungary is biased and constantly accuses Ukraine of violating the rights of its national team living in Transcarpathia. Moreover, after Ukraine adopted the Law on Education, which defines the need for Ukrainian to be studied by representatives of all national minorities living on its territory, Hungary is blocking Kyiv's intentions to move closer to the EU and NATO. Nationalist political forces, which are popular in Eastern European countries and enlist the support of Russia, periodically declare the need to expand the autonomy of Transcarpathia, which may carry the risks of separatism for Ukraine. Hungary also periodically grants citizenship to its national minority, which lives compactly in Transcarpathia due to mass passportization. Nevertheless, we are convinced that Hungary, like all Eastern European countries, is interested in a stable and democratic Ukraine against the background of threats from Russia. For its part, Ukraine needs to implement a comprehensive strategy to counter the threats posed by neighboring countries by supporting dialogue and strengthening strategic partnerships with Hungary, Poland, Slovakia and others. It is a compromise on humanitarian issues that will allow an agreement to be reached between Hungary with Ukraine and a view to its further rapprochement and integration into NATO and the EU.