bluuebunny/crossref_metadata_2025 huggingface dataset:
Integration of proteomics with CT-based qualitative and radiomic features in high-grade serous ovarian cancer patients: an exploratory analysis
Authors: Beer Lucian , Sahin Hilal , Bateman Nicholas W. , Blazic Ivana , Vargas Hebert Alberto , Veeraraghavan Harini , Kirby Justin , Fevrier-Sullivan Brenda , Freymann John B. , Jaffe C. Carl , Brenton James , Miccó Maura , Nougaret Stephanie , Darcy Kathleen M. , Maxwell G. Larry , Conrads Thomas P. , Huang Erich , Sala Evis
Published: April 2020

Objectives

To investigate the association between CT imaging traits and texture metrics with proteomic data in patients with high-grade serous ovarian cancer (HGSOC).

Methods

This retrospective, hypothesis-generating study included 20 patients with HGSOC prior to primary cytoreductive surgery. Two readers independently assessed the contrast-enhanced computed tomography (CT) images and extracted 33 imaging traits, with a third reader adjudicating in the event of a disagreement. In addition, all sites of suspected HGSOC were manually segmented texture features which were computed from each tumor site. Three texture features that represented intra- and inter-site tumor heterogeneity were used for analysis. An integrated analysis of transcriptomic and proteomic data identified proteins with conserved expression between primary tumor sites and metastasis. Correlations between protein abundance and various CT imaging traits and texture features were assessed using the Kendall tau rank correlation coefficient and the Mann-Whitney U test, whereas the area under the receiver operating characteristic curve (AUC) was reported as a metric of the strength and the direction of the association. P values < 0.05 were considered significant.

Results

Four proteins were associated with CT-based imaging traits, with the strongest correlation observed between the CRIP2 protein and disease in the mesentery (p < 0.001, AUC = 0.05). The abundance of three proteins was associated with texture features that represented intra-and inter-site tumor heterogeneity, with the strongest negative correlation between the CKB protein and cluster dissimilarity (p = 0.047, τ = 0.326).

Conclusion

This study provides the first insights into the potential associations between standard-of-care CT imaging traits and texture measures of intra- and inter-site heterogeneity, and the abundance of several proteins.

Key Points

• CT-based texture features of intra- and inter-site tumor heterogeneity correlate with the abundance of several proteins in patients with HGSOC.

• CT imaging traits correlate with protein abundance in patients with HGSOC.
Impact of Assimilation of Radiosonde and UAV Observations from the Southern Ocean in the Polar WRF Model
Authors: Sun Qizhen , Vihma Timo , Jonassen Marius O. , Zhang Zhanhai
Published: April 2020

Weather forecasting in the Southern Ocean and Antarctica is a challenge above all due to the rarity of observations to be assimilated in numerical weather prediction (NWP) models. As observations are expensive and logistically challenging, it is important to evaluate the benefit that additional observations could bring to NWP. Atmospheric soundings applying unmanned aerial vehicles (UAVs) have a large potential to supplement conventional radiosonde sounding observations. Here, we applied UAV and radiosonde sounding observations from an RV Polarstern cruise in the ice-covered Weddell Sea in austral winter 2013 to evaluate the impact of their assimilation in the Polar version of the Weather Research and Forecasting (Polar WRF) model. Our experiments revealed small to moderate impacts of radiosonde and UAV data assimilation. In any case, the assimilation of sounding data from both radiosondes and UAVs improved the analyses of air temperature, wind speed, and humidity at the observation site for most of the time. Further, the impact on the results of 5-day-long Polar WRF experiments was often felt over distances of at least 300 km from the observation site. All experiments succeeded in capturing the main features of the evolution of near-surface variables, but the effects of data assimilation varied between different cases. Due to the limited vertical extent of the UAV observations, the impact of their assimilation was limited to the lowermost 1–2-km layer, and assimilation of radiosonde data was more beneficial for modeled sea level pressure and near-surface wind speed.
MIEO: a micro-invasive endoscopic operation port system for transluminal interventions—an acute and survival porcine study
Authors: Wilhelm D. , Vogel T. , Jell A. , Brunner S. , Kranzfelder M. , Wantia N. , Feussner H. , Ostler D. , Koller S.
Published: April 2020

Background

A reliable and sterile access through the intestinal wall to ease flexible endoscopic transluminal interventions is still appealing but lacks a suitable port system.

Methods

In a granted industry cooperation, we developed the MIEO-Port, a flexible three components overtube system that provides a temporary hermetic sealing of the intestinal wall to allow endoscopic disinfection and manipulation to gain access to the abdominal cavity. The port features an innovative head part which allows for coupling the port to the intestinal wall by vacuum suction and for controlled jetting the isolated intestinal surface with a disinfectant. The device was tested in vivo in 6 pigs for acute and long-term usability. All animal tests were approved by the local ethics committee.

Results

In the acute experiment, the port system supported sealed endoscopic mucosa resection and transluminal cholecystectomy. In the survival study on 5 animals, the MIEO-Port proved its reliability after transcolonic peritoneoscopy. In one animal, a port dislocation occurred after extensive retroperitoneal preparation, one animal revealed bacterial contamination at necropsy; however, all animals showed a favourable course over ten days and offered no signs of peritonitis or abscedation during post-mortem examination.

Discussion

To the best of our knowledge, the MIEO-Port system is the first device to provide a reliable and sterile flexible access to the peritoneal cavity that can be used throughout the entire gastrointestinal tract regardless of the access route and which combines hermetic sealing with local sterilization. Further studies are warranted.
Why do depression, conduct, and hyperactivity symptoms co-occur across adolescence? The role of stable and dynamic genetic and environmental influences
Authors: Waszczuk Monika A. , Zavos Helena M. S. , Eley Thalia C.
Published: April 2020

Depression, conduct, and hyperactivity symptoms are chronic and frequently co-occur in adolescence. Common genetic and environmental vulnerability to these conditions have previously been demonstrated, however, the manner in which common versus disorder-specific etiological influences operate across development and maintain symptom co-occurrence is unclear. Thus, the current study investigated the role of common genetic and environmental influences in the comorbidity of depression, conduct, and hyperactivity across adolescence. Over 10,000 twins and their parents reported adolescents’ symptoms at mean ages 11 and 16 years. Biometric independent pathway models were fitted to estimate genetic and environmental contributions to the continuity of symptom co-occurrence over time, as well as time‐ and symptom‐specific influences. Results found that a common stable genetic factor accounted for the concurrent and longitudinal co-occurrence of depression, conduct, and hyperactivity symptoms. New genetic influences common to these three symptom scales emerged at 16 years, and further contributed to symptom co-occurrence. Conversely, environmental influences largely contributed to the time-specific associations. The findings were generally consistent for self- and parent-reported symptoms. Overall, the results suggest that stable, overlapping genetic influences contribute to the co-occurrence of depression, conduct, and hyperactivity symptoms across adolescence. The results are in line with hierarchical causal models of psychopathology, which posit that much of the developmental co-occurrence between different symptoms is due to common liability. Specifically, current findings indicate that only genetic influences constitute common liability over time. Future studies should identify genetically influenced transdiagnostic risk and maintenance factors to inform prevention and treatment of comorbid internalizing and externalizing symptoms in adolescence.
Influence of electron acceptor availability and microbial community structure on sedimentary methane oxidation in a boreal estuary
Authors: Myllykangas Jukka-Pekka , Rissanen Antti J. , Hietanen Susanna , Jilbert Tom
Published: April 2020

Methane is produced microbially in vast quantities in sediments throughout the world’s oceans. However, anaerobic oxidation of methane (AOM) provides a near-quantitative sink for the produced methane and is primarily responsible for preventing methane emissions from the oceans to the atmosphere. AOM is a complex microbial process that involves several different microbial groups and metabolic pathways. The role of different electron acceptors in AOM has been studied for decades, yet large uncertainties remain, especially in terms of understanding the processes in natural settings. This study reports whole-core incubation methane oxidation rates along an estuarine gradient ranging from near fresh water to brackish conditions, and investigates the potential role of different electron acceptors in AOM. Microbial community structure involved in different methane processes is also studied in the same estuarine system using high throughput sequencing tools. Methane oxidation in the sediments was active in three distinct depth layers throughout the studied transect, with total oxidation rates increasing seawards. We find extensive evidence of non-sulphate AOM throughout the transect. The highest absolute AOM rates were observed below the sulphate-methane transition zone (SMTZ), strongly implicating the role of alternative electron acceptors (most likely iron and manganese oxides). However, oxidation rates were ultimately limited by methane availability. ANME-2a/b were the most abundant microbial phyla associated with AOM throughout the study sites, followed by ANME-2d in much lower abundances. Similarly to oxidation rates, highest abundances of microbial groups commonly associated with AOM were found well below the SMTZ, further reinforcing the importance of non-sulphate AOM in this system.
Modeling the structure and dynamics of transnational illicit networks: an application to cigarette trafficking
Authors: Meneghini Cecilia , Aziani Alberto , Dugato Marco
Published: April 2020

Many illicit markets are transnational in nature: illicit products are consumed in a country different from the one in which they were produced. Therefore, reconstructing the trafficking network and estimating the size of cross-border illicit flows are crucial steps to gain better understanding of these crimes and to enforce actions aimed at countering them. In this respect, the present study outlines a methodology with which to map and size illicit flows and applies it in estimation of transnational cigarette trafficking flows. The proposed methodology traces each step in the paths followed by illicit cigarettes flowing from their origin to the final consumption country and then estimates the quantity of cigarettes moving between each pair of countries. It exploits data on consumption of illicit cigarettes in 57 countries located in Europe, the Middle East, Central Asia, and North Africa, together with data on seizure cases and geographical information for 158 countries worldwide. These data are combined by a function that assigns a likelihood value of illicit cigarettes being transported between any pair of countries. An algorithm is then implemented in order to identify the most likely paths from the origin to the destination country. By merging results for all the different combinations of origins and destinations, this study estimates the size of all cross-border illicit flows and reconstructs a dynamic transnational cigarette trafficking network for the period 2008–2017. The results highlight the multifaceted role of countries in the cigarette trafficking network, the emergence of identifiable cigarette trafficking routes, and the evolution over time of the structure of this transnational illicit network. Finally, the paper discusses how the methodology developed could be adapted to the study of other transnational crimes.
Ein Impuls, Resonanz oder Freiheit – was begründet kritische Gesellschaftstheorie?
Authors: Ellmers Sven
Published: April 2020

Die gegenwärtige Debatte um die normativen Grundlagen kritischer Gesellschaftstheorie weist eine große Bandbreite ethischer Positionen auf: vom (meta-)ethischen Negativismus, der gänzlich auf einen positiven Kritik-Maßstab verzichtet, über Entfremdungs- und Resonanztheorien, die zumindest eine grobe Vorstellung des guten Lebens vermitteln wollen, bis hin zu deontologischen Ansätzen, die Gesellschaftskritik in intelligibler Freiheit begründet sehen. Der folgende Beitrag zeigt, dass diese drei Grundpositionen sich mit Problemen konfrontiert sehen, die der hegelsche Freiheitsbegriff zu lösen vermag.
Comparison of visual analogue scale (VAS) and the Nasal Obstruction Symptom Evaluation (NOSE) score in evaluation of post septoplasty patients
Authors: Shukla Radhika Hiren , Nemade Sanjana Vijay , Shinde Kiran Jaywant
Published: April 2020

Objective

To compare and correlate the efficacy of the NOSE score & the VAS score in determining the symptomatic benefit in patients undergoing septoplasty.

Materials and methods

Eighty patients with deviated nasal septum undergoing septoplasty were included in the study. NOSE score & VAS score (out of 100) was documented before and after surgery. Results were correlated and compared statistically.

Results

In the NOSE score, the most bothersome symptom was trouble breathing through the nose (85.83); followed by Nasal obstruction or blockage (82.50). Wilcoxon test showed significant improvement with NOSE score and VAS score in all patients at 1 month and 3 months. Spearman's coefficient showed a positive correlation between the two, though the score improvement and patient satisfaction rate was significantly high with NOSE score.

Conclusions

NOSE score and the VAS score both provide effective framework for evaluating treatment responses after septoplasty. However, the NOSE score showed higher improvement and better patient satisfaction rate when used to measure of nasal obstruction as compared to the VAS score.
Planning for patient-reported outcome implementation: Development of decision tools and practical experience across four clinics
Authors: Nelson Therese A. , Anderson Brigitte , Bian Jiang , Boyd Andrew D. , Burton Shirley V. , Davis Kristina , Guo Yi , Harris Bhrandon A. , Hynes Kelly , Kochendorfer Karl M. , Liebovitz David , Martin Kayla , Modave François , Moses John , Soulakis Nicholas D. , Weinbrenner Donald , White Sonya H. , Rothrock Nan E. , Valenta Annette L. , Starren Justin B.
Published: April 2020

Introduction:

Many institutions are attempting to implement patient-reported outcome (PRO) measures. Because PROs often change clinical workflows significantly for patients and providers, implementation choices can have major impact. While various implementation guides exist, a stepwise list of decision points covering the full implementation process and drawing explicitly on a sociotechnical conceptual framework does not exist.

Methods:

To facilitate real-world implementation of PROs in electronic health records (EHRs) for use in clinical practice, members of the EHR Access to Seamless Integration of Patient-Reported Outcomes Measurement Information System (PROMIS) Consortium developed structured PRO implementation planning tools. Each institution pilot tested the tools. Joint meetings led to the identification of critical sociotechnical success factors.

Results:

Three tools were developed and tested: (1) a PRO Planning Guide summarizes the empirical knowledge and guidance about PRO implementation in routine clinical care; (2) a Decision Log allows decision tracking; and (3) an Implementation Plan Template simplifies creation of a sharable implementation plan. Seven lessons learned during implementation underscore the iterative nature of planning and the importance of the clinician champion, as well as the need to understand aims, manage implementation barriers, minimize disruption, provide ample discussion time, and continuously engage key stakeholders.

Conclusions:

Highly structured planning tools, informed by a sociotechnical perspective, enabled the construction of clear, clinic-specific plans. By developing and testing three reusable tools (freely available for immediate use), our project addressed the need for consolidated guidance and created new materials for PRO implementation planning. We identified seven important lessons that, while common to technology implementation, are especially critical in PRO implementation.
In search of predictive models for stenolaemate morphometry across the skeletal–polypide divide
Authors: Tamberg Yuta , Smith Abigail M.
Published: April 2020

Marine bryozoans have been members of benthic skeletal faunas since the Ordovician. These small suspension feeders collect particles in the range of 10 to 100 μm. Specific details of their feeding depend on the morphology of the feeding apparatus, which may be reflected in skeletal characters. While several studies have described the link between the skeletal and soft-body traits of gymnolaemate bryozoans, stenolaemates have received less attention. To fill this gap, we conducted a detailed analysis of morphometry within and across species and attempted to develop robust predictive models that can be used to infer the soft-body morphology from skeletal data. This, in turn, will help with extracting data on ecology of Paleozoic communities of suspension feeders from the extensive bryozoan fossil record. Characters of polypide morphology among New Zealand cyclostomates (single Recent order in Stenolaemata) displayed staggering variability and almost without exception were not connected to skeletal characters at the species level. When this variability is reduced to its central tendency, interspecific trends are more apparent. The relationship is positive, linear, and moderately strong, but the resulting models have wide predictive intervals (plus/minus hundreds of micrometers). A precise estimate of the characters of the feeding apparatus of modern, and especially fossil, stenolaemates may be difficult to attain, at least on the basis of the skeletal traits used here.
Science, Catholicism and politics in Argentina (1910–1935)
Authors: DE ASÚA MIGUEL
Published: April 2020

Infin de siècleArgentina a secularist ideology of science was part of the positivist world view espoused by liberals and socialists. Between the years 1910 and 1935, a period in which the Catholic Church experienced a significant cultural expansion, the activities of the Catholic naturalist Ángel Gallardo and the astronomer and priest Fortunato Devoto challenged the so far prevailing idea of science as opposed to religion. This paper explores the connections between the scientific, religious and political aspects of those figures in order to get some insights into the complexity of the relationships between science and secularization in societies with a Catholic majority.
Longitudinal associations between ultra-processed foods and blood lipids in childhood
Authors: Leffa Paula S. , Hoffman Daniel J. , Rauber Fernanda , Sangalli Caroline N. , Valmórbida Júlia L. , Vitolo Márcia R.
Published: April 2020

Emerging evidence suggests that the consumption of ultra-processed foods (UPF) plays a role in the development of chronic diseases, but evidence of their influence in children is limited. Our objective was to study longitudinal trends of UPF intake and determine their impact on blood lipids in young children. The present study was a follow-up of a randomised field trial of children (n308) from Porto Alegre, Brazil. Dietary intake was collected using two 24-h recalls at 3 and 6 years of age, and consumption of UPF was classified according to the NOVA system, a food classification based on the extent and purpose of industrial food processing. At age 6 years, blood tests were performed to measure lipid profile. Contribution of UPF to total energy intake increased by 10 % during the follow-up period, from 43·4 % at 3 years to 47·7 % at 6 years of age. Linear regression models showed that children in the highest tertile of UPF consumption at age 3 years had higher levels of total cholesterol (TC;β0·22 mmol/l; 95 % CI 0·04, 0·39) and TAG at age 6 years (β0·11 mmol/l, 95 % CI 0·01, 0·20) compared with those in the lowest tertile. A positive dose–response was observed for an absolute increment of 10 % of UPF on TC (β0·07 mmol/l, 95 % CI 0·00, 0·14) and TAG (β0·04 mmol/l, 95 % CI 0·01, 0·07). Based on our data, consumption of UPF increased significantly over time and was associated with higher blood lipid levels in children from a low-income community. Our findings highlight the need for effective strategies to minimise the consumption of UPF in early life.
FOUR-MANIFOLDS WITH POSITIVE CURVATURE
Authors: DIÓGENES R. , RIBEIRO E. , RUFINO E.
Published: April 2020

In this note, we prove that a four-dimensional compact oriented half-conformally flat Riemannian manifold M4 is topologically
$\mathbb{S}^{4}$
or
$\mathbb{C}\mathbb{P}^{2}$
, provided that the sectional curvatures all lie in the interval
$\left[ {{{3\sqrt {3 - 5} } \over 4}, 1} \right]$
In addition, we use the notion of biorthogonal (sectional) curvature to obtain a pinching condition which guarantees that a four-dimensional compact manifold is homeomorphic to a connected sum of copies of the complex projective plane or the 4-sphere.
Efficacy of psychological interventions on psychological outcomes in coronary artery disease: systematic review and meta-analysis
Authors: Magán Inés , Casado Laura , Jurado-Barba Rosa , Barnum Haley , Redondo Marta M. , Hernandez Adrian V. , Bueno Héctor
Published: April 2020

Background

The benefits of cognitive-behavioral treatment (CBT) and positive psychology therapy (PPT) in patients with cardiovascular disease are still not well defined. We assessed the efficacy of CBT and PPT on psychological outcomes in coronary artery disease (CAD) patients.

Methods

Randomized controlled trials evaluating CBT or PPT in CAD patients published until May 2018 were systematically analyzed. Primary outcomes were depression, stress, anxiety, anger, happiness, and vital satisfaction. Random effects meta-analyses using the inverse variance method were performed. Effects were expressed as standardized mean difference (SMD) or mean differences (MD) with their 95% confidence intervals (CIs); risk of bias was assessed with the Cochrane tool.

Results

Nineteen trials were included (n = 1956); sixteen evaluated CBT (n = 1732), and three PPT (n = 224). Compared with control groups, depressive symptoms (13 trials; SMD −0.80; 95% CI −1.33 to −0.26), and anxiety (11 trials; SMD −1.26; 95% CI −2.11 to −0.41) improved after the PI, and depression (6 trials; SMD −2.08; 95% CI −3.22 to −0.94), anxiety (5 trials; SMD −1.33; 95% CI −2.38 to −0.29), and stress (3 trials; SMD −3.72; 95% CI −5.91 to −1.52) improved at the end of follow-up. Vital satisfaction was significantly increased at follow-up (MD 1.30, 0.27, 2.33). Non-significant effects on secondary outcomes were found. Subgroup analyses were consistent with overall analyses.

Conclusion

CBT and PPT improve several psychological outcomes in CAD patients. Depression and anxiety improved immediately after the intervention while stress and vital satisfaction improve in the mid-term. Future research should assess the individual role of CBT and PPT in CAD populations.
Association between childhood conditions and arthritis among middle-aged and older adults in China: the China Health and Retirement Longitudinal Study
Authors: Lu Nan , Wu Bei , Jiang Nan , Dong Tingyue
Published: April 2020

This study examined the association between childhood conditions and arthritis among middle-aged and older adults in China. The data were derived from the 2015 wave and the life-history module of the China Health and Retirement Longitudinal Study. Face-to-face interviews were conducted with respondents age 45 and over across China. Multiple imputation was used to handle the missing data, generating a final analytic sample of 19,800. Doctor-diagnosed arthritis was the main outcome variable. Random-effects logistic regression models were used to test the proposed models. Approximately 8 per cent of the respondents had better family financial status in childhood than their neighbours. Close to 8 per cent had been hospitalised or encountered similar conditions (e.g. confined to bed or home) for at least one month in childhood. Around one-third reported better subjective health in childhood than their peers. The majority of the respondents (80%) reported that they had stable health resources, and that their mothers were illiterate during their childhood. Childhood family financial status, subjective health, mother's education, access to health care and medical catastrophic events were found to be significant factors associated with arthritis in later life, after controlling for adulthood and older-age conditions (family financial status: odds ratio (OR) = 0.885, 95 per cent confidence interval (95% CI) = 0.848–0.924; subjective health: OR = 0.924, 95% CI = 0.889–0.960; mother's education: OR = 0.863, 95% CI = 0.750–0.992; access to health care: OR = 0.729, 95% CI = 0.552–0.964; medical catastrophic events: OR = 1.266, 95% CI = 1.108–1.446). The study results highlight an important role that childhood conditions play in affecting the onset of arthritis in late life in China. Health-care providers may consider childhood conditions as a valuable screening criterion to identify risk populations, which could be used to guide health promotion and prevention programmes, and promote healthy ageing.
Nano-wrinkles, compactons, and wrinklons associated with laser-induced Rayleigh–Taylor instability: I. Bubble environment
Authors: Lugomer Stjepan
Published: April 2020

We study dynamics, structure and organization of the new paradigm of wavewrinkle structures associated with multipulse laser-induced RayleighTaylor (RT) instability in the plane of a target surface in the circumferential zone (C-zone) of the spot. Irregular target surface, variation of the fluid layer thickness and of the fluid velocity affect the nonlinearity and dispersion. The fluid layer inhomogeneity establishes local domains arranged (organized) in the «domain network». The traveling wavewrinkles become solitary waves and latter on become transformed into stationary soliton wavewrinkle patterns. Their morphology varies in the radial direction ofaussian-like spot ranging from the compacton-like solitons to the aperiodic rectangular waves (with rounded top surface) and to the periodic ones. These wavewrinkles may be successfully juxtapositioned with the exact solution of the nonlinear differential equations formulated in the KadomtsevPetviashvili sense taking into account the fluid conditions in particular domain. The cooling wave that starts at the periphery by the end of the pulse causes sudden increase of density and surface tension: the wavewrinkle structures become unstable what causes their break-up. The onset of solidification causes formation of an elastic sheet which starts to shrink generating lateral tension on the wavewrinkles. The focusing of energy at the constrained boundary causes the formation of wrinklons as the new elementary excitation of the elastic sheets.
Liberal or Conservative? The Differentiated Political Values of the Middle Class in Contemporary China
Authors: Qin Guangqiang
Published: April 2020

This article analyses data from the 2015 Chinese General Social Survey (CGSS) to investigate the differentiated political values of the middle class in China. Combining the two factors of market situation and institutional division, the article first categorizes several basic types of middle class and then identifies two kinds of political values (liberal and conservative) from the indicators of support for freedom, government satisfaction, and political voting. The results show that the middle class, as a whole, tends to be more liberal than the working class. However, the internal divisions among the sub-groups in the middle class are more obvious – the political tendency of the middle class within the redistribution system is conservative but the middle class sub-groups outside the system, especially the new middle class, have the most liberal tendencies and constitute a potential source for change in China. Thus, the middle class is not necessarily a stabilizer or a subverter of the status quo and has a heterogeneous nature shaped by the dual forces of markets and institutions.
Bandwidth improvement of planar antennas using a single-layer metamaterial substrate for X-band application
Authors: Borazjani O. , Naser-Moghadasi M. , Rashed-Mohassel J. , Sadeghzadeh R. A.
Published: April 2020

To prevent far-field radiation characteristics degradation while increasing bandwidth, an attempt has been made to design and fabricate a microstrip antenna. An electromagnetic band gap (EBG) structure, including a layer of a metallic ring on a layer of Rogers 4003C substrate, is used. For a better design, a patch antenna with and without the EBG substrate has been simulated. The results show that the bandwidth can be improved up to 1.6 GHz in X-band by adding the EBG substrate. Furthermore, using this structure, a dual-band antenna was obtained as well. Finally, to validate the simulation results, a comparison has been done between simulation data and experimental results which demonstrate good agreement.
Cholinergic-pathway-weakness-associated pancreatic islet dysfunction: a low-protein-diet imprint effect on weaned rat offspring
Authors: Mathias Paulo Cezar de Freitas , Miranda Ginislene Dias Souza , Barella Luiz Felipe , Miranda Rosiane Aparecida , Pavanello Audrei , Martins Isabela Peixoto , Facchi Júlia Cristina , Costermani Hercules de Oliveira , Lima Thalyne Aparecida Leite de , de Oliveira Júlio Cezar
Published: April 2020

Currently, metabolic disorders are one of the major health problems worldwide, which have been shown to be related to perinatal nutritional insults, and the autonomic nervous system and endocrine pancreas are pivotal targets of the malprogramming of metabolic function. We aimed to assess glucose–insulin homeostasis and the involvement of cholinergic responsiveness (vagus nerve activity and insulinotropic muscarinic response) in pancreatic islet capacity to secrete insulin in weaned rat offspring whose mothers were undernourished in the first 2 weeks of the suckling phase. At delivery, dams were fed a low-protein (4% protein, LP group) or a normal-protein diet (20.5% protein, NP group) during the first 2 weeks of the suckling period. Litter size was adjusted to six pups per mother, and rats were weaned at 21 days old. Weaned LP rats presented a lean phenotype (P < 0.01); hypoglycaemia, hypoinsulinaemia and hypoleptinaemia (P < 0.05); and normal corticosteronaemia (P > 0.05). In addition, milk insulin levels in mothers of the LP rats were twofold higher than those of mothers of the NP rats (P < 0.001). Regarding glucose–insulin homeostasis, weaned LP rats were glucose-intolerant (P < 0.01) and displayed impaired pancreatic islet insulinotropic function (P < 0.05). The M3 subtype of the muscarinic acetylcholine receptor (M3mAChR) from weaned LP rats was less responsive, and the superior vagus nerve electrical activity was reduced by 30% (P < 0.01). A low-protein diet in the suckling period malprogrammes the vagus nerve to low tonus and impairs muscarinic response in the pancreatic β-cells of weaned rats, which are imprinted to secrete inadequate insulin amounts from an early age.
The Indigenous Inheritance: Critical Antecedents and State Building in Latin America and Southeast Asia
Authors: Slater Dan , Soifer Hillel David
Published: April 2020

In comparative-historical analysis, countries are always different places before critical junctures set them on divergent pathways. By comparing the legacies of politicized ethnic diversity for the construction of state infrastructural power in Latin America and Southeast Asia, we elaborate the methodological and substantive importance of these “critical antecedents.” The critical antecedent in each region was the inheritance at independence of a sharp indigenous cleavage. This indigenous inheritance shaped threat perceptions and state-society coalitions in both regions in similarly powerful path-dependent ways—yet in intriguingly divergent directions. A salient indigenous cleavage hindered but did not preclude state building in nineteenth-century Peru, while fostering but not predestining state building in post–World War II Malaysia. Divergent levels of postcolonial state infrastructural power thus exhibit deep if indirect foundations in the identity cleavages inherited from preindependence eras. This cross-region comparative exploration highlights the analytical leverage gained from systematically incorporating preexisting cross-case differences into critical juncture accounts.
Early clinical outcomes for treatment of post-thrombotic syndrome and common iliac vein compression with a hybrid Oblique self-expanding nitinol stent – the TOPOS study
Authors: Sebastian Tim , Lichtenberg Michael , Schlager Oliver , Jalaie Houman , de Graaf Rick , Erbel Christian , Massmann Alexander , Schindewolf Marc , Grigorean Alexandru , Kucher Nils
Published: April 2020

Summary: Background: Physical attributes of conventional stents used in the ilio-caval territory are often unfavorable in the presence of external compression close to the bifurcation. A hybrid oblique stent was developed for the treatment of common iliac vein compression without compromising the contralateral iliac vein inflow. Patients and methods: The ongoing international monitored TOPOS study enrolled 60 patients with post-thrombotic syndrome (PTS) treated with the sinus-Obliquus stent (optimed) and provisional distal stent extension. At 3-month follow-up, patency rates were obtained from duplex ultrasound, and clinical outcomes were assessed by the Villalta score, revised venous severity score (rVCSS), pain intensity score and chronic venous disease quality of life questionnaire (CIVIQ-20). Results: Mean age was 46.6 ± 14.9 years (68.3 % women). Mean number of implanted stents was 1.9 ± 0.6; 12 (20 %) patients received the hybrid oblique stent only. Forty-eight (80 %) patients had distal stent extension, and 42 (70 %) had stents below the inguinal ligament. Four (7 %) patients (all with stent extension) developed stent thrombosis. Primary and secondary patency rates at 3 months were 93.1 % (95 %CI 83.3–98.1 %), and 100 % (95 %CI 93.8–100 %), respectively. Improvement in Villalta, rVCSS, CIVIQ-20, and pain intensity score from baseline to 3-month follow-up was 6.9 ± 1.4 points (95 %CI 4.1–9.8; p < 0.0001), 3.4 ± 1.0 points (95 %CI 1.3–5.4 points; p < 0.01), 13.6 ± 2.7 points (95 %CI 8.2–19.0 points; p < 0.0001), and 2.4 ± 0.5 (95 %CI 1.4–3.3; p < 0.0001), respectively. At follow-up, 38 (63 %) patients were free from the PTS and none developed contralateral deep vein thrombosis. Conclusions: In patients with PTS and common iliac vein compression, treatment with the hybrid oblique stent with provisional stent extension resulted in high patency rates and improvement in PTS severity and quality of life at 3-month. Two-year results of TOPOS will assess the durability of this treatment.
Assessing Cognitive Capacity by P3 During a Complex Manual Control Task
Authors: Johannes Bernd , Bubeev Juri A. , Kotrovskaya Tatyana I. , Bronnikov Sergey V. , Piechowski Sarah , Elmenhorst Eva-Maria , Rittweger Jörn , Jordan Jens , Gaillard Anthony W. K.
Published: April 2020

Abstract. Our aim was to adapt a classical P3 method to assess the free cognitive capacity during spacecraft docking training in space. Electroencephalogram (EEG) measurement in space is limited by several conditions. Based on experience with our own EEG experiments on MIR and ISS, we decided to use dry electrodes and restricted the electrode placement to the forehead. We examined whether P3 can be reliably obtained under these conditions. Subjects had to perform a manually controlled docking task simultaneously with an acoustic monitory task. The P3 component was evoked by the acoustic stimuli of the secondary task. Twenty-six subjects participated in this study, situated in a space simulation on earth. After a familiarization session, they performed the docking tasks at three difficulty levels: low, medium, and difficult. In the secondary task, subjects had to discriminate between a low (750 Hz) and a high (1,000 Hz) tone, which differed in probability of 90% and 10%, respectively. The subjects had to count the high tone and after 10 relevant tones and had to give a voice command to a power supply configuration. P3 amplitude was largest and the latency shortest during the medium difficult task. A decision matrix based on differences between the relevant and irrelevant P3 was calculated for each subject and each task. The results suggest that P3 can be recorded during a complex manual control task and can be used to assess individual free cognitive capacity.
Precision Seismic Monitoring and Analysis at Axial Seamount Using a Real‐Time Double‐Difference System
Authors: Waldhauser F. , Wilcock W. S. D. , Tolstoy M. , Baillard C. , Tan Y. J. , Schaff D. P.
Published: April 2020

Seven three‐component ocean bottom seismometers (OBS) of the Ocean Observatories Initiative (OOI) Cabled Array on top of Axial Seamount are continuously streaming data in real time to the Incorporated Research Institutions for Seismology (IRIS). The OBS array records earthquakes from the submarine volcano which last erupted on 24 April 2015, about 4 months after the array came online. The OBS data have proven crucial in providing insight into the volcano structure and dynamics (Wilcock et al., 2016, https://doi.org/10.1126/science.aah5563). We implemented a real‐time double‐difference (RT‐DD) monitoring system that automatically computes high‐precision (tens of meters) locations of new earthquakes. The system's underlying double‐difference base catalog includes nearly 100,000 earthquakes and was computed using kurtosis phase onset picks, cross‐correlation phase delay times, and 3‐D P and S velocity models to predict the data. The relocations reveal the fine‐scale structures of long‐lived, narrow (<200 m wide), outward dipping, convex faults on the east and west walls of the caldera that appear to form a figure 8‐shaped ring fault system. These faults accommodate stresses caused by the inflation of magma prior to and deflation during eruptions. The east fault is segmented and pulled apart in east‐west direction due to its interaction with the Juan de Fuca Ridge, which at this location forms an overlapping spreading center. The RT‐DD system enables the monitoring and rapid analysis of variations in fine‐scale seismic and fault properties and has the potential to improve prediction of timing and location of the next Axial eruption expected to occur in the 2022–2023 time frame.
Tracking Fluid Flow in Shallow Crustal Fault Zones: 2. Insights From Cross‐Hole Forced Flow Experiments in Damage Zones
Authors: Brixel B. , Klepikova M. , Lei Q. , Roques C. , Jalali M. R. , Krietsch H. , Loew S.
Published: April 2020

Cross‐hole fluid injection tests were performed on shallow (0.5 km depth) crustal fault zones to characterize their internal flow structures on scales of 3–30 m. The data were acquired at the Grimsel Rock Laboratory, Switzerland, after the zonal isolation of damage zones in boreholes equipped with multipacker systems. We show that 80% of the pressure responses detected evolved as a power function of time due to fracture‐controlled flow and were best described by a fractional model with a flow dimension (n) in the range of [1.3,1.5]. The scaling of characteristic times (tc) and intermediate transitions in the flow dimension is shown to be inconsistent with the trend expected for normal diffusion, indicating a diffusion slowdown process caused by the spatial integration of structurally different damage zones. An analysis of the entire data set points to a subdiffusive regime where the mean squared displacement of pressure fronts, ⟨r2(t)⟩, scales as ⟨r2(t)⟩∝t0.59, similar to an anomalous diffusion process on synthetic fractal systems. We characterize this diffusion slowdown by calculating a network connectivity exponent (θ) of 1.4, from which we estimate a fractal dimension of df=2.23 for the tested fault zones. Such a value close to 2.0 supports the view of fault damage zones as hierarchical systems promoting flow channeling. Our results provide further support to theoretical models of fractional flow and their application to fractured media in nature.
Convective Boundary Layer Control of the Sea Surface Temperature in the Tropics
Authors: Hourdin Frédéric , Rio Catherine , Jam Arnaud , Traore Abdoul‐Khadre , Musat Ionela
Published: April 2020

Using successive versions of a global climate model, we show how convective transport to the free troposphere of the humidity evaporated at the surface or, reciprocally, entrainment of dry air from the free troposphere into the mixed layer, controls surface evaporative cooling and then sea surface temperature. This control is as important as the radiative effect of boundary layer clouds on radiation. Those aspects are shown to be improved when activating a mass flux representation of the organized structures of the convective boundary layer coupled to eddy diffusion, the so‐called “thermal plume model,” leading to an increased near‐surface drying compared to the use of turbulent diffusion alone. Controlling detrainment by air properties from just above the boundary layer allows the thermal plume model to be valid for both cumulus and stratocumulus regimes, improving the contrast in near‐surface humidity between the trade winds region and East Tropical oceans. Using pairs of stand‐alone atmospheric simulations forced by sea surface temperature and of coupled atmosphere‐ocean simulations, we show how the improvement of the surface fluxes that arise from this improved physics projects into an improvement of the representation of sea surface temperature patterns in the coupled model, and in particular into a reduction of the East Tropical Ocean warm bias. The work presented here led to the bias reduction in sea surface temperature in the Institute Pierre Simon Laplace coupled model, IPSL‐CM6A, developed recently for the 6th phase of the Coupled Model Intercomparison Project, CMIP6.
Integrative analysis of lithium treatment associated effects on brain structure and peripheral gene expression reveals novel molecular insights into mechanism of action
Authors: Anand Amit , Nakamura Kunio , Spielberg Jeffrey M. , Cha Jungwon , Karne Harish , Hu Bo
Published: April 2020

Lithium is a highly effective medication for bipolar disorder, but its mechanism of action remains unknown. In this study, brain MRI scans and blood samples for gene expression (total of 110 scans and 109 blood samples) were collected from 21 bipolar subjects before and after 2 and 8 weeks of lithium monotherapy and at the same time-points from untreated 16 healthy controls. We used linear mixed-effects models to identify brain structural features and genes with expression changed after lithium treatment, with correction for multiple testing, and correlated their concurrent changes to identify molecular pathways associated with lithium effects. There are significant increases in gray matter fraction, global cortical thickness, and the frontal and parietal cortices after 8 weeks of lithium treatment (correctedp < 0.05). Volume increases were also seen for putamen, hippocampus, thalamic nuclei, and thalamic substructures. Several genes showed significant expression changes, and 14 gene pathways were identified for the present integration analysis. Of these, nine pathways had significant correlations with structural changes (FDR < 0.05). Three neurotrophy-related pathways (GDNF family of ligands, NFAT immune-response, and p53-signaling pathway) correlated with structural changes in multiple regions. Mediation analysis showed that the sphingomyelin metabolism pathway is associated with HAM-D change (p < 0.01), and this effect is mediated via the volume of mediodorsal thalamus (p < 0.03). In summary, the integration of lithium effects on brain structural and peripheral gene expression changes revealed effects on several neurotrophic molecular pathways, which provides further insights into the mechanism of lithium action.
Spectroscopic-network-assisted precision spectroscopy and its application to water
Authors: Tóbiás Roland , Furtenbacher Tibor , Simkó Irén , Császár Attila G. , Diouf Meissa L. , Cozijn Frank M. J. , Staa Joey M. A. , Salumbides Edcel J. , Ubachs Wim
Published: April 2020

Frequency combs and cavity-enhanced optical techniques have revolutionized molecular spectroscopy: their combination allows recording saturated Doppler-free lines with ultrahigh precision. Network theory, based on the generalized Ritz principle, offers a powerful tool for the intelligent design and validation of such precision-spectroscopy experiments and the subsequent derivation of accurate energy differences. As a proof of concept, 156 carefully-selected near-infrared transitions are detected for H216O, a benchmark system of molecular spectroscopy, at kHz accuracy. These measurements, augmented with 28 extremely-accurate literature lines to ensure overall connectivity, allow the precise determination of the lowest ortho-H216O energy, now set at 23.794 361 22(25) cm−1, and 160 energy levels with similarly high accuracy. Based on the limited number of observed transitions, 1219 calibration-quality lines are obtained in a wide wavenumber interval, which can be used to improve spectroscopic databases and applied to frequency metrology, astrophysics, atmospheric sensing, and combustion chemistry.
Exposure measurement error and the characterization of child exposure to fecal contamination in drinking water
Authors: Goddard Frederick G. B. , Chang Howard H. , Clasen Thomas F. , Sarnat Jeremy A.
Published: April 2020

Characterizing fecal contamination exposure from drinking water can introduce exposure measurement errors, i.e., differences between the observed and true exposure. These errors can mask the true relationship between fecal contamination exposure and waterborne diseases. We present a framework to quantify the impact of measurement errors on exposure–outcome health effect estimates introduced by variability in measured drinking water fecal contamination levels and household versus community sampling strategies. We matched fecal indicator bacteria (FIB) data for >37,000 drinking water samples to children aged 0–72 months from 19 studies in low- and middle-income countries and took two complementary analytical approaches. We found that household-level exposure assessments may attenuate effect estimates of FIB concentrations in drinking water on diarrhea, and single water samples may attenuate health effect estimates of FIB concentrations on linear growth. To understand the health effects of fecal contamination exposure, measurement error frameworks can be used to estimate more biologically relevant exposures.