bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of changes in the serotonin inactivation coefficient in brain structures with simultaneous modeling of chronic neurogenic pain and malignant neoplasia
Authors: Kotieva I. M. , Frantsiyants E. M. , Shlyk S. V. , Drobotya N. V. , Gulyan M. V. , Dodokhova M. A.
Published: April 2023

Introduction. Chronic pain syndrome in the development of malignant neoplasms has a complex polyethological character. The study of the pathogenetic mechanisms of pain during the growth of the transplanted tumor in the experiment can open up broad perspectives for the creation of new domestic analgesic drugs for use in oncology.

Aim: To study the serotonin inactivation coefficient (SIC), the ratio of serotonin (S) and its main metabolite 5-hydroxyindolacetic acid (S-OH) in brain areas (cortex, hypothalamus) with simultaneous modeling of chronic neurogenic pain and malignant neoplasia.

Material and Methods. The study involved white mongrel rats (males). To create a model of chronic pain (CP), ligation of the sciatic nerve was performed according to the method of V.V. Kravtsova in modification. Rat sarcoma M-1 was used to simulate malignant neoplasia. At the main stage of the study, the animals were divided into 4 groups: control, two comparison groups (model of chronic pain, standard M-1 sarcoma grafting) and experimental (combined modeling of CP and oncological process). Animals of the second, third and fourth groups were euthanized sequentially at the 2nd and 3rd weeks of the development of the tumor process.

Results. Chronic pain syndrome disrupts the process of serotonin metabolism: the decrease in SIC in the cerebral cortex of experimental animals was more significant by 48% (day 14) and 72% (day 21). The development of the oncological process in comparison groups (groups 3a and 3b) is accompanied by a decrease in the level of SIC, more significant at the 21th day of M-1 sarcoma development: by 37% in the hypothalamus, by 41% in the cerebral cortex. With simultaneous modeling of chronic neurogenic pain and malignant neoplasia, the lowest values of the studied indicator were noted, the decrease was 75% in the cerebral cortex (group 4a) and 87% (group 4b).

Discussion. Chronic neurogenic pain and M-1 sarcoma development in isolated modeling variants cause a significant decrease in SIC in hypothalamus and cerebral cortex due to disorders of serotonin formation. A more significant disruption of the serotonin mediator system was noted in cerebral cortex which leads to a decrease in the body’s adaptive capabilities to pain and a disruption of the regulatory mechanisms of metabolism.

Conclusion. Modification of serotonin metabolism can be considered as a potential therapeutic target for the treatment of chronic pain syndrome in oncology.
Analysis of the effectiveness of various protein coatings for optimizing the endothelialization of polymer matrices
Authors: Velikanova E. A. , Matveeva V. G. , Senokosova E. A. , Khanova M. U. , Krivkina E. O. , Antonova L. V.
Published: April 2023

Background. Due to the constant increase in the number of surgeries to restore blood flow in the affected vessels, the development of synthetic prostheses is relevant. One of the key success factors is an increase in the adhesive properties of the inner surface, since the rapid endothelialization of vascular prostheses is considered a factor necessary to prevent thrombosis and neointimal hypertrophy.

Aim: To determine the effect of surface modification of polymer matrices with fibrin, fibronectin, or type I collagen on the adhesion and viability of endothelial cells.

Material and Methods. Polymer matrices prepared by electrospinning from a mixture of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) and poly(ε-caprolactone) were studied. Matrix samples were coated with type I collagen or fibronectin or fibrin. Then, human umbilical vein endothelial cells (HUVEC) were colonized on the matrices and cultured for 3 days. Unmodified matrices and culture plate wells were used as controls. Cell viability was assessed by combined staining with Hoechst 33342 and ethidium bromide. The metabolic activity of the cells was studied using the MTT test. Cell adhesion was analyzed by staining for F-actin. Statistical analysis of the results was performed using the GraphPrism 7.0 program.

Results. It was found that the number of adherent cells and their metabolic activity of matrices with collagen did not differ from unmodified ones. Coating with fibronectin demonstrated higher rates of cell adhesion to the surface.  However, a rather high level of cell death in this group indicates that such a modification cannot fully ensure the normal functioning of cells. Finally, we observed the best results when using a fibrin coating, which was comparable to culture plastic in terms of adhesion and viability of endothelial cells.

Conclusion. Modification of the surface of polymer matrices with fibrin can significantly improve their adhesive properties and can be used in the development of polymer prostheses for small-diameter vessels.
Functional state of the glutathione system in the adipose tissue of rats with metabolic syndrome
Authors: Birulina Ju. G. , Ivanov V. V. , Buyko E. E. , Voronkova O. V.
Published: April 2023

Aim: To study the functional state of the components of the glutathione-dependent antioxidant system in the adipose tissue of rats with experimental metabolic syndrome (MetS).

Material and Methods. The MetS model was carried out on male Wistar rats using a high-fat, high-carbohydrate diet (HFHCD). Body and adipose tissue weight were measured. Blood serum levels of glucose, insulin, leptin, triacylglycerides and cholesterol were assessed. In epididymal adipose tissue the level of reactive oxygen species (ROS) was determined by fluorescent method. The concentration of reduced (GSH) and oxidized (GSSG) glutathione, activity of glutathione reductase, glutathione peroxidase, and glutathione-S-transferase enzymes were assessed spectrophotometrically in epididymal adipose tissue.

Results. It was found that HFHCD led to an increase in body weight, obesity, hyperglycemia, insulin resistance, dyslipidemia, and leptinemia in the experimental group rats. An increase in adipose tissue mass had a positive correlation with an increase in the concentration of glucose, serum leptin, and ROS levels in the epididymal adipose tissue of rats with MetS. It was found that the level of total glutathione in the adipose tissue of the experimental group rats decreased mainly due to a decrease in the level of GSH. The rats receiving HFHCD also showed a decrease in the activity of glutathione peroxidase and glutathione-S-transferase, but the activity of glutathione reductase increased.

Conclusion. Obesity, as a key component of MetS, is a trigger of insulin resistance, chronic low-grade inflammation and oxidative stress. The study showed that the development of MetS and obesity in the experimental animal group is accompanied by a shift of adipocyte redox balance toward oxidative stress, which is expressed in a decrease of GSH/GSSG ratio and glutathione-dependent antiperoxide protection enzymes activity.
اللُّغة والهُويّة في خطاب المذكرات عند إدوارد سعيد
Authors: برهومة عيسى عودة
Published: April 2023

تتناولُ الدراسةُ مسألةَ اللغةِ والهُويَّةِ عند المفكِّر الفلسطينيّ النشأة الأمريكيّ الجنسيّة إدوارد سعيد، للكشف عن حيثيّات هذا التعالُق بترسيمَاتِهِ المختلفة؛ الاجتماعيّة والسياسيّة والنَّفسيّة والجماليّة، وبما أنتجه هذا التعالُق في خطاباتِهِ السِّياسِيّة في المحافل الدوليّة من متانةِ الأسلوب وقوةِ العبارة؛ حيثُ أحدَثَ امتلاكه لِهُويَّتَين متنافرتين ولغتين مختلفتين رَجَحَتْ كفَّةُ إحداهما على الأُخرى في مُفارقةٍ أسهمت في نتائجَ عديدةٍ، وسارت نحو تحقيق وجوديّة الهُويّة العربيّة الفلسطينيّة تحقيقًا مُغايرًا عمَّا هو مُتعارَفٌ عليه في خطاباتِ الحُريَّة والنضال الفكريّ السياسيّ. سعى البحثُ إلى الكشف عن كيفيّة ارتباط الهُويَّة الأصل بلغة الهُويَّة المُكتَسَبة في خطاب المذكرات عند إدوارد سعيد، وتأمُّلاتِه حول المنفَى، والبحثِ في أسباب ميل إدوارد سعيد لهويّةِ وطنٍ نُفِيَ عنه لمدةٍ طويلةٍ والانتماء إليه بلغة المنفى، ثم تكريسِ حياته العمليّة والفكريّة في النضال من أجل الوطن، وحقيقةِ تمسُّكِه بلغته الأولى أو تخلّيه عنها، وماذا شكَّلَ المنفى بالنسبة إليه والذي مؤدَّاه إعادته إلى هجعةِ النشأة الأولى والتَّحوُّل إلى العمل السِّياسيّ المقاوِم. وغيرها من التساؤلات التي تُوجِبُ على الدِّراسةِ أن تتناولها بالبحثِ وعُمق النَّظَر؛ من أجلِ مباحثةٍ سابرةٍ لتلك التساؤلات. وتحقيقًا لهذه الغاية جاءت الدراسةُ في عددٍ من المَحاوِر التي تُجيبُ عن تساؤلاتٍ إشكاليّةِ الهُويَّة واللغة، وكيفيّة تعاضُدهما في خطاب السيرة الذاتية عند إدوارد سعيد، ونتائج تحقُّق هذه العمليّة الصعبة التي تَلَت مرحلة طويلة من المخاضِ قبل ولادتها؛ للوقوف على مظاهر ميَّزَت السرد السير ذاتي في جذوره ونتائجه وغيرها من العناوين المُدرجة في مُتونِ هذا البحث. وانتهت الدراسةُ إلى أنَّ خطابَ الهُويَّة وتعالُقَه مع اللغة عند إدوارد سعيد يمثِّلُ خطابًا جماليًّا فريدًا بشتى جوانبه، ومُكتنزًا ومعبأً بالدّلالات والرَّسَائل الضمنيّة، التي تُسفر عن تجليات الذات، والأنا، والهُويَّة، والنِّضَال والمُقَاومة.
PROPOSAL FOR AN EXTENDED CS-L MODEL
Authors: Gueye Mamadou Salla
Published: April 2023

It was in the very first hours of a meeting. A brand-new Associate of Management Sciences (Option Marketing) and I, his first PhD student, discussed in a restaurant near the University Cheikh Anta Diop de Dakar (UCAD). That’s when the idea of the present Model first emerged. This discussion continues at the Marché aux Puces, in our adjoining rooms of the Cité Internationale Universitaire de Paris (CIUP) and at the restaurant of the same Cité...After the emergence of the idea, there followed the process of its maturation and the laying of the milestones of the present model proposal. To complete the reflection and the puzzle of the construction of this model, it took multiple immersions in different appropriate media. In particular, our immersions at the CIRRELT of the LAVAL University of Quebec as well as the links established were particularly fruitful. Today, the Model has grown...So, the proof of the ripening of this Model, since its emergence, starts from a long conception. This design was followed by a step-by-step construction until its completion. This completion is – today – the fruit of this present Model ([7, op. cit.], Montoussé and Waquet (2006), Gueye et al. (2020), Gueye et al. (2020), Gueye et al. (2020).But there is always room for improvement, as nothing here is sacred and definitive. Everything turns and changes.
Factors affecting immigrants’ host country language proficiency: Focusing on the differences between migrant workers and marriage-migrant women in South Korea
Authors: Park In Young , Park Seongseog , Lee Sungjun , Min Byeonggon
Published: April 2023

This study aims to reveal significant factors affecting the Korean language proficiency of immigrants in Korea by comparing the two immigrant groups, migrant workers and marriage-migrant women, that constitute the largest sector of the foreign-born population in Korea. A comprehensive survey was conducted on a total of 136 migrant workers and 136 marriage-migrant women. A statistical analysis was followed adopting stepwise multiple regression on six independent variables (age at arrival, length of residence, education level, linguistic distance, intensity of target language use, and learning time at institutions) and one dependent variable (self-reported language proficiency). Results show that length of residence in Korea and intensity of target language use significantly contributed to the Korean language proficiency of marriage-migrant women, whereas age at arrival, intensity of target language use, and education level played a significant role in the development of language proficiency of migrant workers in Korea. Educational implications are discussed, and suggestions are made for expanding language educational support for migrant workers.
Language teaching and settlement for newcomers in the digital age: A blended learning research project
Authors: Cummings Jill , Sturm Matthias , Avram Augusta
Published: April 2023

Blended Learning (BL) in English language learning programs in Canada is defined as the combination of f2f learning with instructor-facilitated use by students of online activities and resources that complement the in-class teaching (Kennell & Moriarty, 2014). Blended Learning is increasingly in demand by students, teachers, and programs (Garrison & Vaughan, 2008), particularly in the Language Instruction for Newcomers to Canada (LINC) program, the English language and settlement program provided by Immigration, Refugees, and Citizenship Canada (IRCC) in Canada (Kennell & Moriarty, 2014). This article explains the findings of a demonstration research project regarding the effects of blended learning in LINC for students, instructors, and the program. The blended approach shows promise for enhancing English language learning and access to LINC classes for newcomers to Canada via technologies important in our digital age. The research findings here regarding the effects of BL in LINC are important in light of the need to enhance accessibility to English language learning for newcomers to Canada and the paucity of research related to BL for English language learning and settlement needs (Kennell & Moriarty, 2014; Lawrence, 2014).
National cyber-physical ecosystem: Theoretical and methodological aspects
Authors: Zubritskaya I.
Published: April 2023

At the present stage of social development, the need has been identified for the formation and development of the theory and methodology of the economic and organizational foundations of the formation of the national cyberphysical ecosystem as a result of the digital transformation of the branches of the national economy in the cyber-physical space. The scientific publication presents the results of the study of the genesis of the theory of ecosystems, cyberphysical systems, digital ecosystems. The object of the study is the national cyberphysical ecosystem, which is considered as an integral part of the cyberphysical space. The relevance of the scientific problems of the theory and methodology of the formation of the national cyberphysical ecosystem is revealed. The subject of the study is the formation of new organizational and economic object-object, subject-object and subject-subject relations of multiple relations. The definition of the concept of «national cyberphysical ecosystem» is developed, the directions of formation of the national cyberphysical ecosystem are proposed.
DESENVOLVIMENTO DE SOFTWARE EM LINGUAGEM DE PROGRAMAÇÃO PYTHON PARA A CONTAGEM DE COLÔNIAS BACTERIANAS A PARTIR DA BIBLIOTECA OPENCV
Authors: Araújo Charles Cleython Maia Fernandes de , Costa Clayton Maciel , Rocha Francisco Angelo Gurgel da , Silva Lucas Gabriel Souza , Medeiros Pedro Adson da Cunha
Published: April 2023

Levando em consideração a ação de microrganismos patogênicos e a necessidade de monitorá-los e de quantificar o seu crescimento em meios como a água ou alimentos, visando a preservação da saúde pública, torna-se necessário o aprimoramento de métodos de contagem de colônias de microrganismos em placas de Petri. Objetivou-se a elaboração de um software simples e de baixo custo para a contagem automática de
colônias de bactérias de formato regular, serão usadas a linguagem de programação Python, bem como sua biblioteca de processamento de imagens OpenCV. A avaliação da efetividade do algoritmo foi realizada por meio da comparação com resultados de contagens manuais obtidos a partir de imagens simuladas de placas de petri contendo colônias de bactérias aeróbias mesófilas, Staphylococcus aureus e S. epidermis.
The place of US for the diagnosis of clinically suspected abdominal bleeding in trauma patients
Authors: Atanas Dimitrov Hilendarov  , Alexander Georgiev Georgiev  , Lyubomir Georgiev Chervenkov
Published: April 2023

Aims and Objectives: The detection of liquid collections remains a challenge for the trauma team, especially when there is multiple trauma. We present our experience in the diagnosis, follow-up and planning therapy of free and encapsulated abdominal liquid collections by performing ultrasound examination. Methods: 143 emergency trauma patients /116 male and 27 female/ were examined using ultrasound for a period of 2 years. The right and left oblique and propositioning view was used for US examination to identify free and bounded liquid collections in the abdominal cavity. The examination was performed immediately after the initial clinical survey with patients supine. Positive findings of liquid collections on US were compared with those provided by CT, punctures under US control or surgery. US machine supplied with 3.5 and 7 MHz linear and convex transducers, MDCT device, needles and catheters were used. Results: One hundred and fifteen /80.41%/ of all 143 US examined trauma patients had free and encapsulated liquid collections, confirmed by CT scan, surgery, or clinical course. In 59 /51.30%/ patients we performed fine needle puncture under US control. There were 95 true-positives, 14 true-negatives, 2 false-positives and fore false-negative results. Overall this demonstrated that ultrasonography had a sensitivity of 95.95%, specificity of 87.50% and accuracy of 94.78%. The PPV is 97.93% and the NPV – 77.77%. Conclusion: Our experience and literature reports support the opinion that US examination should be used as a primary method for diagnosis and follow-up of abdominal liquid collections in emergency patients.
Pupils’ trait emotional intelligence and life satisfaction on academic achievement in the new normal
Authors: Joshua Padilla Reyes  , Ayrel Gem Crisostomo Dionisio
Published: April 2023

This study determined the influence of pupils’ trait emotional intelligence and life satisfaction on the academic achievement in the new normal of Grade six pupils in San Ildefonso South District, San Ildefonso, Bulacan during the School Year 2021-2022. With explanatory sequential method as research design and 297 pupils as respondents of the study, findings showed that the public elementary school pupils’ trait emotional intelligence in terms of well-being, self-control, and emotionality was described as “above average.” On the other hand, their trait emotional intelligence in terms of sociability was described as “average.” Meanwhile, the public elementary school pupils strongly agreed that they are satisfied with their family. On the other hand, these respondents agreed that they are satisfied with their friends, self, school and living environment. The academic achievement of the public elementary school pupils was described as “very satisfactory.” Based on the findings of the study, the following conclusions were drawn: There is a significant relationship between the public elementary school pupils’ trait emotional intelligence in terms of well-being and their academic achievement. There is a significant relationship between the public elementary school pupils’ life satisfaction and their academic achievement in the new normal.
Relationship between working period and nutritional status with work fatigue workers in PT X production unit
Authors: Elvania Della Tri Widya Listyowati  , Aisyah Aulyanti Affilin
Published: April 2023

Work fatigue is still prevalent both in the world and Indonesia. International Labour Organization (ILO) data in 2016 shows that 32% of workers in the world experience work fatigue. Workers with more nutritional status and long working period feel headaches, fatigue all over the body, anxiety, legs in the shoulders and back pain during work. This condition is a symptom of work fatigue. This study included quantitative research with an analytical observational type of research. The research design used was cross sectional. The population of this study was all workers of line V production unit at PT X with a total sample of 34 people. The results showed that 26.47% of workers experienced mild work fatigue, 61.77% of workers experienced moderate work fatigue and 11.76% of workers experienced severe work fatigue. There is a significant relationship between working time and work fatigue with a p-value of 0.000 with a value of r = 0.752 which shows a strong correlation. In addition, there is also a significant relationship between nutritional status and work fatigue with a p-value of 0.009 with a value of r = 0.443 which shows a weak correlation. There is a relationship between the variables of working time and nutritional status with work fatigue. Companies are expected to rotate work by paying attention to the length of work and nutritional status of workers, so as to minimize the occurrence of work fatigue.
Data and Fair use
Authors:   Korea Copyright Commission, Kim Yun-Myung
Published: April 2023

Data collection and use are the beginning and end of machine learning. Looking at ChatGPT, data is making machines comparable to human capabilities. Commercial purposes are not naturally rejected in the judgment of fair use of the process of producing or securing data for system learning. The UK, Germany, and the EU are also introducing copyright restrictions for data mining for non-profit purposes such as research studies, and Japan is more active. Japan’s active legislation is the reason why there are no comprehensive fair use regulations like Korea and the United States, but it shows its willingness to lead the artificial intelligence industry. In 2020, a revision to the Copyright Act was proposed in Korea to introduce restrictions for information analysis. It will be able to increase the predictability for operators. However, the legislation of the amendment is expected to be opposed by the right holder and may take time. Therefore, it was examined whether machine learning such as data crawling and TDM corresponds to fair use through fair use under the current copyright law. In conclusion, it was considered that it may correspond to fair use, citing that it is different from human use behavior. However, it is questionable whether it is reasonable to attribute all exclusive negligence to the business operator by using the works of others according to fair use. The reason why the compensation system for profits earned by operators through the use of machine works generated by TDM or machine learning cannot be excluded from the possibility of serious consequences for a fair competitive environment.
EXPRESSION PATTERNS OF SOME LIPOGENIC GENES AND FATTY ACID PROFILE OF LIVER IN FOOD-RESTRICTED RATS
Authors: ÖZKAN Hüseyin , KARAASLAN İrem , KAYA Ufuk , DALKIRAN Sevda , ALAKUŞ İbrahim , ÇAMDEVİREN Baran , KEÇELİ Hasan Hüseyin , YAKAN Akın
Published: April 2023

This study aimed to determine food restriction effects on the profile of fatty acids and major genes on lipogenesis expressions in liver.16 Wistar albino rats were divided into two groups and different diets were given to groups for 4-weeks. First group was fed ad libitum (Control group), another group was fed the half amount of the daily requirement (Food Restriction group, FR). As well as weekly food consumption and body weight changes, total cholesterol, HDL, LDL, and triglyceride levels were determined at the end of the feeding period. In addition to the fatty acid profile, FASN and SCD-1 genes expression levels were measured in the liver. While the body weight averages decreased after 7 days and remained similar, plasma glucose levels were found lower in the FR. FASN was upregulated approximately 6 folds, and SCD-1 increased insignificantly about 3 folds in the FR. C15:0, C18:1 n9 trans, C18:2 n6 cis, C21:0, C20:2, C20:5 n3, n6 and UFA were lower, while C16:0, C18:2 n6 trans, C20:3 n6, C22:6 n3, C22:1 n9, C22:2 and SFA were higher in FR. In addition to considering the exposure time and rate of food restriction, molecular activity and interactions in other metabolic organs should be investigated.
Framework zur Evaluierung der Erweiterbarkeit cloudbasierter ERP-Systeme
Authors:   Universität Potsdam, Nitzschke Alexander , Schmalstich Maik , Ehlert Marco , Völl Wolfgang
Published: April 2023

Die Anpassbarkeit cloudbasierter ERP-Systeme ist systembedingt limitiert, da nur auf diese Weise viele Mandanten effizient in einem SaaS-Ansatz bedient werden können. Dennoch müssen Prozesse immer wieder angepasst oder gegebenenfalls lokal ausgeprägt werden. Durch Verlagerung der technischen Kompetenz hin zum SaaS-Provider nimmt die technische Kompetenz in Unternehmen sukzessive ab. Low-Code-Plattformen können eine Option sein, diese Prozessanpassungen über fachliche Anwendungsentwickler (sogenante Citizen Developer) zu ermöglichen. Doch wann lassen sich Prozesse in einem cloudbasierten System gut abbilden, über eine Low-Code-Plattform modifizieren und wann nicht? In diesem Artikel wird ein Framework vorgestellt, das bei der Analyse von potenziell in ERP-Systemen abbildbaren Prozessen mittelständischer Dienstleistungsunternehmen unterstützt. Das Resultat ist die Ermittlung geeigneter Anpassungsoptionen mit anschließender Priorisierung.
Zukünftige Datenorganisation in ERP-Systemen - eine Analyse etablierter Datenbankansätze
Authors:   Universität Potsdam, Bender Benedict , Bertheau Clementine ,   Universität Potsdam, Körppen Tim ,   Universität Potsdam, Lauppe Hannah ,   Universität Potsdam, Gronau Norbert ,   Universität Potsdam
Published: April 2023

Die digitale Transformation stellt neue Anforderungen an Unternehmenssysteme. Insbesondere ERP-Systeme haben damit zu kämpfen, die neuen Anforderungen aus Industrie 4.0, Multichannel-Handel, Industrial Internet of Things u. a. auf allen Ebenen ihrer Architektur zu erfüllen. Dieser Beitrag zeigt die Notwendigkeit, die Gesamtarchitektur der Systeme zu überdenken und die damit verbundenen Probleme am Ursprung zu adressieren. Viele Einschränkungen der Anpassungsfähigkeit von ERP-Systemen hängen mit der Standardisierung von Daten zusammen. Datenbanken dienen als Grundlage für die Speicherung und den Abruf von Daten, schränken aber die Flexibilität von Unternehmenssystemen und die Möglichkeit, sich an neue Anforderungen anzupassen, ein. Sechs Datenbankkonzepte für ERP-Systeme wurden untersucht, um den ERP-Anbietern aufzuzeigen, wie Datenbankkonzepte zu zukunftsfähigen Lösungen kombiniert verwenden können.
Exploring Test Concept andMeasurement Through Validity andReliability Process inTVET Research: Guideline forThe Novice Researcher
Authors:   Universiti Tun Hussein Onn Malaysia, Mohd Salleh Kahirol , Sulaiman Nor Lisa ,   Universiti Tun Hussein Onn Malaysia, Gloeckner Gene ,   Colorado State University
Published: April 2023

Validity and reliability are important aspects of research, especially in social science and TVET research. The scales used in research that are important factors to enable good research results. The objective of this paper is to provide insight into important concepts of validity and reliability and also to introduce the major methods to assess validity and reliability as they relate to social science and TVETresearch. The research design and approach used for this study was a non-experimental research design. The data are using retrospective data and descriptive statistics which were used to run the simulation and analysis. The outcome of this research suggests that Cronbach’s Alpha is the best method to use when checking the reliability in terms of internal consistency. The alpha provides various information that can benefit the researcher, especially in novice research, The result from the simulation shows the importance of conducting validity and reliability test during the research process. It not only provided evidence but also confidence because it reflected consistency and accuracy.
PERTUMBUHAN, PRODUKSI, DAN KUALITAS JAGUNG HITAM (Zea mays L.) PADA BERBAGAI DOSIS KALIUM NITRAT
Authors: Veriska Laudia , Rochman Nur , Yulianti Nani
Published: April 2023

Penelitian ini bertujuan untuk mengetahui pertumbuhan, produksi, dan kualitas jagung hitam (Zea mays L.) pada berbagai dosis kalium nitrat. Penelitian menggunakan benih jagung hitam varietas black aztec. Media tanam yang digunakan adalah tanah, arang sekam, dan pupuk kandang kambing. Penelitian menggunakan Rancangan Acak Lengkap faktor tunggal yaitu pupuk kalium nitrat yang terdiri dari 6 taraf dengan dosis 0 g/tanaman, 5 g/tanaman, 10 g/tanaman, 15 g/tanaman, 20 g/tanaman, dan 25 g/tanaman. Analisis data menggunakan sidik ragam (uji F) dan uji lanjut DMRT pada taraf 5%. Hasil penelitian menunjukkan bahwa, perlakuan dosis KNO3 10 g/tanaman memberikan hasil yang paling tinggi pada setiap peubah amatan pertumbuhan dan produksi tanaman jagung hitam. Namun pada peubah amatan kadar gula, dosis KNO3 25 g/tanaman paling tinggi dibandingkan dengan perlakuan lainnya.
KERAGAAN DAN HUBUNGAN KEKERABATAN MUTAN PUTATIF BAWANG PUTIH HASIL IRADIASI SINAR GAMMA
Authors: Sopyan M , Setyono  , Yuliawati Yuliawati
Published: April 2023

Mutan-mutan putatif bawang putih generasi MV4 telah diperoleh melalui induksi iradiasi sinar gamma. Mutan-mutan putatif tersebut masih perlu dievaluasi, sehingga dapat diidentifikasi mutan-mutan putatif dengan karakter unggul. Penelitian ini bertujuan untuk mengevaluasi keragaan dan kekerabatan mutan-mutan putatif bawang putih hasil iradiasi sinar gamma. Penelitian dilaksanakan pada bulan April sampai dengan Juni 2021 di kebun percobaan IPB University, Pasir Sarongge, Cianjur. Rancangan penelitian yang digunakan adalah rancangan tersarang, terdiri atas 3 ulangan dan 2 faktor uji, yaitu varietas bawang putih lokal dan perlakuan iradiasi sinar gamma. Varietas bawang putih terdiri atas 3 taraf, yaitu varietas Tawangmangu Baru, Lumbu Kuning, Ciwidey, sementara perlakukan iradiasi sinar gamma terdiri atas 5 taraf, yaitu 0 Gy, 2 Gy, 4 Gy, 6 Gy, 8 Gy. Pengamatan dilakukan terhadap karakter kuantitatif dan kualitatif bawang putih berdasarkan UPOV. Hasil percobaan menunjukkan bahwa heritabilitas populasi bawang putih uji tergolong rendah sampai sedang dan keragaman genetiknya tergolong sempit. Varietas bawang putih hanya nyata mempengaruhi karakter tinggi tanaman 8 MST, sementara perlakuan iradiasi sinar gamma nyata mempengaruhi karakter tinggi tanaman 4 MST dan 8 MST, jumlah daun 4 MST dam 8 MST, dan diameter umbi. Terdapat keragaman di antara populasi bawang putih pada karakter keberadaan bulbil, bentuk umbi, bentuk dasar umbi, keberadaan siung eksternal, dan ketebalan kulit umbi. Kekerabatan diantara populasi bawang putih tergolong tidak dekat sampai sangat dekat dengan tingkat kemiripan tertinggi terdapat pada mutan putatif Tawangmangu Baru 2 Gy dengan Lumbu Kuning 2 Gy.
“Protected Teaching Spaces”: Opportunities and Constraints When Teaching for the edTPA
Authors: Lohwasser Karin , Long Caroline , Shim Soo-Yean , Windschitl Mark
Published: April 2023

Preservice teacher performance assessments, such as the edTPA, are one of the accountability policies from states and local authorities designed to ensure the quality of beginning teachers and standardize teacher education. We studied experiences of 65 preservice teachers regarding the effect of the edTPA on their learning in field-placement classrooms. These cases revealed that the edTPA created “protected teaching spaces” for participants to experiment with student-centered instructional practices supported in university courses and codified in edTPA rubrics. This was especially impactful for novices who previously had limited opportunities to try out equitable reform-oriented instruction in their placements. In these cases, the edTPA also helped mitigate inequities in learning to teach, an unintended outcome that is important for policymakers to consider when deciding on credentialing requirements.
Is It Who You Are or Where You Are? Accounting for Compositional Differences in Cross-Site Treatment Effect Variation
Authors: Lu Benjamin , Ben-Michael Eli , Feller Avi , Miratrix Luke
Published: April 2023

In multisite trials, learning about treatment effect variation across sites is critical for understanding where and for whom a program works. Unadjusted comparisons, however, capture “compositional” differences in the distributions of unit-level features as well as “contextual” differences in site-level features, including possible differences in program implementation. Our goal in this article is to adjust site-level estimates for differences in the distribution of observed unit-level features: If we can reweight (or “transport”) each site to have a common distribution of observed unit-level covariates, the remaining treatment effect variation captures contextual and unobserved compositional differences across sites. This allows us to make apples-to-apples comparisons across sites, parceling out the amount of cross-site effect variation explained by systematic differences in populations served. In this article, we develop a framework for transporting effects using approximate balancing weights, where the weights are chosen to directly optimize unit-level covariate balance between each site and the common target distribution. We first develop our approach for the general setting of transporting the effect of a single-site trial. We then extend our method to multisite trials, assess its performance via simulation, and use it to analyze a series of multisite trials of adult education and vocational training programs. In our application, we find that distributional differences are potentially masking cross-site variation. Our method is available in the balancer R package.
Betaine and Soluble Fiber Improve Body Composition and Plasma Metabolites in Cats with Chronic Kidney Disease
Authors: Ephraim Eden , Jewell Dennis E.
Published: April 2023

Background: Chronic kidney disease (CKD) is a common condition in cats and cachexia (loss of lean body mass) is a concern. A nutrition-based intervention was investigated in cats with CKD for its effects on body composition, the plasma metabolome, and possible implications on health. Methods: After a 4-week prefeed period with the control food, cats with CKD (N = 24) were randomized to one of six groups to consume a control food; a food supplemented with 0.5% betaine, 0.39% oat beta-glucan, and 0.27% short-chain fructooligosaccharides (scFOS, test food 1); and a food supplemented with 0.5% betaine, 0.59% oat beta-glucan, and 0.41% scFOS (test food 2) in a William’s Latin Square design, each for 10 weeks. Body composition was assessed via dual-energy X-ray absorptiometry measurements, and the plasma metabolome was characterized. Results: Despite no significant differences in daily intake among the three foods, significant increases in total body mass, lean body mass, and lean plus bone mineral composition were observed when cats with CKD consumed test food 1 compared with the control food; numerical increases were seen with test food 2 versus the control food. Plasma metabolomics indicated increased one-carbon metabolism following consumption of test food 1 and/or 2, with significant increases in sarcosine and numerical increases in methionine. Lower levels of plasma trans-4-hydroxyproline and N-methylproline following consumption of test foods 1 and 2 indicates reduced collagen breakdown and perhaps reduced fibrosis. Several acylcarnitines and branched-chain fatty acids associated with CKD were also reduced when cats ate test food 1 or 2 versus the control food. Higher plasma levels of sphingomyelins with consumption of test food 1 or 2 may reflect less severe CKD. Conclusions: Consumption of foods with supplemental betaine and fibers by cats with CKD led to improvements in body composition and changes in the plasma metabolome that correspond to better kidney health.
MORPHOGENESIS PATHWAYS IN VITRO IN ISOLATED ANTER CULTURE OF WHEAT: THE ROLE OF PHYTOHORMONE BALANCE
Authors:   Ufa Institute of Biology of the Ufa Federal Research Centre of the Russian Academy of Sciences, Seldimirova O.A. , Galin I.R. ,   Ufa Institute of Biology of the Ufa Federal Research Centre of the Russian Academy of Sciences, Abramov S.N. ,   Ufa Institute of Biology of the Ufa Federal Research Centre of the Russian Academy of Sciences
Published: April 2023

The study is aimed to the study of the peculiarities of the induction of morphogenesis pathways in vitro of morphogenetically competent anther cells - microspores in the isolated anther culture of a number of spring soft wheat genotypes, recommended for cultivation in the climatic conditions of the Republic of Bashkortostan. The content of IAA in seedlings of the studied genotypes of spring sof wheat was analyzed to determine the class of the genotype – characterized by high or low auxin content. Such morphogenesis pathways in vitro as embryoidogenesis, polyembryoidogenesis and callusogenesis have been identified and studied. Morpho-histological assessment of androclinic structures is given. It was established that the induction of a certain morphogenesis pathway in vitro is determined mainly by the balance between the content of endogenous auxin IAA in anthers before inoculation on a nutrient medium and the concentration of exogenous synthetic auxin 2,4-D in the composition of the nutrient medium. The fundamental possibility of regulation of morphogenesis pathways in vitro in isolated anther culture of wheat by selecting for each genotype an adequate balance of endogenous and exogenous auxins for the induction of a specific pathway has been shown.
ALLAH MEMBANGKITKAN HAMBANYA
Authors: Harahap Ramli
Published: April 2023

Hari ini kita merayakan Paskah II. Pada Ibadah Paskah II ini kita akan membahas tema “Allah Membangkitkan Hamba-Nya”. Ungkapan "Bagi kamulah pertama-tama Allah membangkitkan Hamba-Nya dan mengutus-Nya kepada kamu" dalam Kisah 3:26 merupakan bagian dari kesaksian Petrus dan Yohanes setelah mereka menyembuhkan seorang lumpuh di pintu gerbang Bait Suci. Dalam kesaksian mereka, Petrus dan Yohanes mengajarkan tentang pekerjaan Allah dalam membangkitkan Yesus Kristus dari kematian dan mengutus-Nya untuk memberikan keselamatan kepada manusia.
Hadist Tematik Birrul Walidain
Authors: nurhayati siti
Published: April 2023

Birrul Walidain adalah bagian dalam etika islam yang menunjukkan kepada tindakan berbakti (berbuat baik) kepada kedua orang tua. yang mana berbakti kepada orang tua ini hukumnya fardhu (wajib) ain bagi setiap muslim, meskipun seandainya kedua orang tuanya adalah non muslim. setiap muslim wajib mentaati setiap perintah dari keduanya selama perintah tersebut tidak bertentangan dengan perintah Allah. Dan Birrul Walidain merupakan bentuk silaturahim yang paling utama.
Lupa dalam Perspektif Hadis
Authors: Faridjahal Gunawan Al-
Published: April 2023

Lupa atau forgetfulness dalam perspektif hadis adalah suatu kondisi dimana seseorang mengalami kehilangan atau kurangnya kemampuan untuk mengingat sesuatu yang sebelumnya telah dikenal atau dipelajari. Dalam konteks hadis, lupa dapat menjadi masalah serius karena hadis merupakan salah satu sumber utama dalam agama Islam yang digunakan untuk memahami dan mengambil hukum atau ajaran-ajaran agama.Ketika seseorang lupa terkait hadis, maka ia dapat mengalami kesulitan dalam memahami ajaran-ajaran agama, mengamalkannya dengan benar, atau bahkan menyampaikannya kepada orang lain. Oleh karena itu, penting bagi umat Islam untuk memahami cara mengatasi lupa dalam konteks hadis agar dapat mempertahankan keaslian dan keutuhan ajaran agama.Dalam hal ini, hadis memberikan banyak informasi dan petunjuk tentang cara mengatasi lupa. Beberapa hadis bahkan memberikan saran tentang cara meningkatkan daya ingat dan menghindari lupa. Oleh karena itu, pemahaman yang benar tentang hadis dan perspektifnya terhadap lupa akan sangat membantu bagi umat Islam dalam mempelajari, memahami, dan mempraktikkan ajaran agama secara tepat dan benar.
Blocked training facilitates learning of multiple schemas
Authors: Beukers Andre Oliveira , Collin Silvy H. P. , Kempner Ross , Franklin Nicholas T. , Gershman Samuel J. , Norman Kenneth A
Published: April 2023

We all possess a mental library of schemas that specify how different types of events unfold. How are these schemas acquired? A key challenge is that learning a new schema can catastrophically interfere with (i.e., overwrite) old knowledge. One solution to this dilemma is to use interleaved training to learn a single representation that accommodates all schemas. However, another class of models posits that catastrophic interference can be avoided by splitting off new representations when large prediction errors occur. A key differentiating prediction is that, according to splitting models, catastrophic interference can be prevented even under blocked training curricula. We conducted a series of semi-naturalistic experiments and simulations with Bayesian and neural network models to compare the predictions made by the “splitting” versus “non-splitting” hypotheses of schema learning. We found better performance in blocked compared to interleaved curricula, and explain these results using a Bayesian model that incorporates representational splitting in response to large prediction errors. In a follow-up experiment, we validated the model prediction that inserting blocked training early in learning leads to better learning performance than inserting blocked training later in the learning process. Our results suggest different learning environments (i.e., curricula) play an important role in shaping schema composition. We discuss the different roles prediction errors have for “carving nature at its joints”.
Sustainable tourism in Sleman, Indonesia: government communication strategy in empowering community through the development of tourism village
Authors: Prayudi Prayudi
Published: April 2023

Changing the mindset of the community and empowering them to develop tourism villages was always a challenge. It was even more challenging when the development of the tourism village was to adopt a sustainable development approach. The government needed to work together with other stakeholders if this policy was to succeed. This study examined how the Sleman Tourism Agency in Indonesia developed and planned a communication strategy to empower the community through the development of tourism villages based on the sustainable development approach. It used a qualitative research method to understand how the government communicated and empowered the community to develop a sustainable tourism village. The adoption of the public relations management process gave a detailed description of the communication strategy. There were four steps that the Sleman Tourism Agency had to follow in developing a communication strategy for community empowerment. Further, this study also identified the stakeholder that the government collaborated with through the ABCGM pentahelix model. There was an identification of the role of each relevant stakeholder in developing a tourism village. Finally, this paper argued that the Sleman Tourism Agency initiated a sustainable tourism village program but required communication and collaboration with other stakeholders in its development.
YouTube Vs television in media convergence era: case study study on tonight show program presented by Net Mediatama
Authors: Pembayun Estavita Chantik
Published: April 2023

The use of the internet has become a habit among millennials lately. The products of these two media are television and YouTube. Presentation of content that is considered almost the same, namely using audio-visual media, YouTube is considered to be a new medium that will shift and even replace the existence of the television industry. In 2020, We are Social analysis said the number of YouTube users reached 2 billion each month. This has a significant impact on television, one of which is NET (News and Entertainment Television) that owned by PT NET Mediatama. The increasing number of YouTube viewers compared to declining television, NET experienced a decline in revenue in 2020, due to a continuous decrease in audience ratings with the number of sponsors obtained. As a conventional media, NET now has to compete with YouTube. The program that is the focus of this research is the Tonight Show, where the program is broadcast hybridly in terrestrial form and exclusively on YouTube streaming. The research was conducted using a constructivist paradigm and a qualitative approach with a case study method. Interviews with assistant producers of the Tonight Show became primary data and published interviews, media content and literature that examined the convergence of communication media and industry became secondary data. Based on research findings from a business point of view, convergence in the television industry can open up new professional opportunities, such as providing opportunities for television media managers to expand public choice, as has been implemented by the Tonight Show program with the Tonight Show Premiere. Even though YouTube viewers in Indonesia are increasing, the existence of the television industry still has its place, because exposure to television content can be felt by more people compared to YouTube, because not everyone can access the internet, especially in Indonesia.
Young people as a user of Tik Tok: creative works and entertainment connoisseurs
Authors: Setiawan Albert Octavio
Published: April 2023

Social media has expanded since globalization and digitization. This causes social media to become a place for every generation to enjoy entertainment or create entertainment itself. Some of the social media currently available are Facebook, Instagram, TikTok, and others. These three social media have something in common, providing entertainment in the form of short videos. Tiktok is one of the social media applications on the rise and invites application users to be creative when creating content in the form of videos. Someone who was previously unknown to many people in the TikTok application becomes an influencer or public figure if the audience of the TikTok application likes the videos or the work of the video maker. Researchers will use descriptive qualitative methods by interviewing three sources whose have different backgrounds. By using the theory of use and gratification, researchers will see that the TikTok application connoisseur and the creator of the uploading works have a satisfying effect when watching or seeing good feedback from the audience of the application.
PEMANFAATAN BIOCHAR BERBAHAN DASAR AMPAS TEBU (Saccharum Officinarum Linn) SEBAGAI BAHAN PEMBENAH TANAH PADA LAHAN BEKAS TAMBANG BATUBARA
Authors: Nazella Elma
Published: April 2023

Mining activities in South Kalimantan are carried out openly which have an impact on changes in soil structure due to excavation of top soil to reach deeper layers of mining material. The soil in the mining area is infertile with a high acidity level with very low nutrients, water retention, unstructured, and the content of elements is toxic. Therefore, it is necessary to carry out treatment through remediation of mining land to restore the carrying capacity of the soil. One alternative that can be used is biochar made from bagasse. This study aims to determine the characteristics of bagasse biochar and see the effect of using bagasse biochar with variations in dosage and contact time on the soil improvement process in stabilizing pH and eliminating soil Fe levels. The soil remediation process was carried out on a laboratory scale with various doses of biochar (0 g, 7.5 g, 15 g and 30 g) and contact time (15 days, 30 days, and 45 days). The results showed that bagasse biochar has characteristics that meet the requirements as a soil enhancer based on pH, C/N ratio, organic C, total N, CEC, total P, total K, ash content and water content. The results of remediation carried out for 45 days showed that bagasse biochar was able to neutralize the initial pH from 4.9 to 6.9 and was able to reduce Fe levels by 8158.1 mg/kg.Keyworld: Biochar, Sugarcane Bagasse Mining Land, Heavy Metal (Fe), pH