bluuebunny/crossref_metadata_2025 huggingface dataset:
Planar liquid crystal optics for simultaneously surface displaying and diffraction-limited focusing
Authors: Shao Zhenglong , Xie Xin , Zhou Yingjie , Zhang Xiaohu , Du Wenjuan , Fan Fan , Tang Dongliang
Published: August 2022

Planar optical elements have attracted widespread attentions because of their precise light modulation. Liquid crystals (LCs) are well known for their applications in the current displaying field, and show great potential in planar optical elements with the development and innovation of LC micro-operation technology. However, previous researches on LC elements mainly involved only one type of optical manipulation, which inevitably limited the functional diversity. In this work, we propose a multifunctional LC element which integrates the surface display into a binary-phase focusing lens by controlling the complex amplitude of the incident light. The light modulation of the anisotropic LC molecule satisfies a sinusoidal variation, which can be regarded as the combination of a continuous amplitude modulation and a binary phase modulation. The element with millimeter size is then fabricated, and the experimental measurements agree well with our design with a high-definition surface pattern and high-quality optical focusing/imaging performance. Furthermore, as the complex amplitude modulation changes from sine to cosine function after rotating the sample by 45°, a bifocal lens with two different focal lengths is also demonstrated. We expect the proposed multifunctional LC elements can find applications in information multiplexing, image displaying, etc.
Microstructural analysis as a requirement for sinter-based additive manufacturing of highly conductive copper
Authors: Ott J. , Burghardt A. , Britz D. , Mücklich F.
Published: August 2022

To further improve the range of battery-powered electric vehicles, new concepts in power electronics are required. The use of so-called “wide-bandgap” semiconductor materials, such as SiC, could meet the need for even more powerful power electronics, but this also increases the demands on the thermal management of the components. Complex copper cooler structures adapted to the temperature field could be a suitable way to meet these increasing requirements for heat dissipation.

However, conventional manufacturing techniques such as forging, casting and milling are reaching their limits for the production of complex Cu structures, and new processes such as additive manufacturing are coming into focus.

Additive manufacturing processes such as selective laser melting (SLM) place high demands on the laser system for highly-conductive copper (Cu) [1]. This means that less established sinter-based processes such as binder jetting (BJ) or fused filament fabrication (FFF) are also suitable for the production of complex Cu structures. In sinter-based methods, the sintering process and the microstructure, which is strongly influenced by it, is crucial for achieving good physical properties of the component [2].

In this work, methods are presented that allow for a quantitative and qualitative evaluation of the sintering process of copper at the microstructure level in order to derive optimized process parameters that enable higher sintering densities and thus greater conductivities. The influence of residual porosity and impurities on conductivity was investigated and allows for a specific prediction of the expected conductivity of sintered Cu structures.
Thermodynamic behavior and crystal structure of polypropylene treated with supercritical carbon dioxide
Authors: Shao Wenjun , Liu Li-Zhi , Liu Chao , Wang Ying , Hua Xia , He Yadong , Shi Ying
Published: August 2022

Controlling temperature and pressure during the supercritical carbon dioxide (scCO2) process can change the mount of CO2 entered in polypropylene (PP) phase, thereby changing the mechanical properties of materials. The effect of scCO2 treatment on the crystallization behavior is different in the semi-molten and molten states. This study investigates the PP treated with scCO2 near the melting point and at various pressures, and explores the effects of temperature and pressure on the crystal structure, lamellar structure, and thermodynamic properties of PP. The results show that at a melting temperature of 165 °C, scCO2 can enhances the ability of PP molecules to makes the PP crystal region more regular, and forms larger microcrystals and lamellae. Additionally, increasing the pressure can make more CO2 enter the PP crystal region and further improve the regularity of the crystal. At a semi-melting temperature of 155 °C, scCO2 is primarily in the amorphous region because it is difficult to enter the PP crystal region. Even if increasing the pressure, it has little effect on the crystal size and lamellar thickness of PP. The research has significant implications for developing and utilizing scCO2 to remove ash from materials.
Some results on the generalized Brownian bridge
Authors: Hadiri Soukaina , Sghir Aissa
Published: August 2022

The generalized Brownian bridge

X

a
,
b
,
T

{X^{a,b,T}}

from a to b of length T was used in several fields such as in mathematical finance, biology and statistics. In this paper, we study the following stochastic properties and characteristics of this process: The Hölder continuity, the self-similarity, the quadratic variation, the Markov property, the stationarity of the increments,
and the α-differentiability of the trajectories.
Investigation of the properties of electrically conductive interpenetrating polymer networks for the use as temperature sensors
Authors: Ziemer Thorben , Ziegmann Gerhard , Rembe Christian
Published: August 2022

We report on our newest studies of electrically conductive interpenetrating polymer networks (IPNs) for application in temperature micro sensors. We manufactured polymeric structures on glass with a micro pattern generator by exposing a combination of Novolak and Terthiophene doped with copper(II) perchlorate with a UV laser. We assessed the effects of prolonged temperature loads on the structures’ impedances in a range of 30 to 130 °C. Such polymers and our approach may be of interest for the fabrication of different micro sensors, particularly when only a limited number of highly specialized sensors is required, e.g. for fire safety infrastructure.
Statistical evaluation of absolute change versus responder analysis in clinical trials
Authors: Wang Peijin , Peskoe Sarah , Byrd Rebecca , Smith Patrick , Breslin Rachel , Chow Shein-Chung
Published: August 2022

In clinical trials, the primary analysis is often either a test of absolute/relative change in a measured outcome or a corresponding responder analysis. Although each of these tests may be reasonable, determining which test is most suitable for a particular research study remains an open question. These tests may require different sample sizes or define different clinically meaningful differences; most importantly, they may lead to different study conclusions. The aim of this study was to compare a typical non-inferiority test using absolute change as the study endpoint to the corresponding responder analysis in terms of sample-size requirements, statistical power, and hypothesis-testing results. From numerical analysis, using absolute change as an endpoint generally requires a larger sample size; therefore, when the sample size is the same, the responder analysis has higher power. The cut-off value and non-inferiority margin are critical and can meaningfully affect whether the two types of endpoints yield conflicting conclusions. Specifically, extreme cut-off values are more likely to yield different conclusions. However, this influence decreases as population variance increases. One important reason for conflicting conclusions is a non-normal population distribution. To eliminate conflicting results, researchers should consider the population distribution and cut-off value selection.
The Earworm Technique Applied in Telehealth Music Therapy Program during the COVID-19 Outbreak in China
Authors:   International Association of Music and Medicine, US/China, Gao Tian
Published: August 2022

This article describes the details of a new technique, the earworm technique, which is suitable for online music therapy in the situation of the coronavirus 2019 (COVID-19) outbreak. The technique was used in a music therapy service provided through a free and publicly available hotline in China during the outbreak, with satisfactory results. Of 103 cases, 83% were successful, 8% were helpful, 7% were unsuccessful, and 3% were incomplete. The technique is a combination of Erickson’s modern hypnosis techniques and music therapy. It is easy to train for and perform, making it suitable for a one-time intervention with online music therapy service.
Intersectionality and Intersectional Analysis in the Arts Therapies: How Does It Enhance Our Thinking about Social Justice?
Authors:   Derby University, UK, Hogan Susan
Published: August 2022

The usefulness of intersectional analysis is explored. Its implications for enhancing arts therapies practice are set out and analyzed in detail. In particular, intersectional analysis is discussed in relation to gender issues. A case study is then offered to illustrate the practical application of the concept. An argument is made for the introduction of further critical theory to be taught in our curriculums to enhance critical pedagogy.
Lateralization of Autonomic Output in Response to Limb-Specific Threat
Authors: Kryklywy James H. , Lu Amy , Roberts Kevin H. , Rowan Matt , Todd Rebecca M.
Published: August 2022

In times of stress or danger, the autonomic nervous system (ANS) signals the fight or flight response. A canonical function of ANS activity is to globally mobilize metabolic resources, preparing the organism to respond to threat. Yet a body of research has demonstrated that, rather than displaying a homogenous pattern across the body, autonomic responses to arousing events, as measured through changes in electrodermal activity (EDA), can differ between right and left body locations. Surprisingly, an attempt to identify a function of ANS asymmetry consistent with its metabolic role has not been investigated. In the current study, we investigated whether asymmetric autonomic responses could be induced through limb-specific aversive stimulation. Participants were given mild electric stimulation to either the left or right arm while EDA was monitored bilaterally. In a group-level analyses, an ipsilateral EDA response bias was observed, with increased EDA response in the hand adjacent to the stimulation. This effect was observable in ∼50% of individual participants. These results demonstrate that autonomic output is more complex than canonical interpretations suggest. We suggest that, in stressful situations, autonomic outputs can prepare either the whole-body fight or flight response, or a simply a limb-localized flick, which can effectively neutralize the threat while minimizing global resource consumption. These findings are consistent with recent theories proposing evolutionary leveraging of neural structures organized to mediate sensory responses for processing of cognitive emotional cues.
Ośrodek Badań Historii Kobiet Instytutu Studiów Kobiecych. Dokonania, plany naukowe, perspektywy badawcze
Authors:   Uniwersytet w Białymstoku, Miodowski Adam
Published: August 2022

The summary of the achievements of the Women’s History Research Center in 2019–2021 as part of the “DIALOG” grant program is positive. This is an incentive for the research team associated with the Center to continue cooperation in the following years. A new field of joint activity under the ministerial program “SOCIAL RESPONSIBILITY OF SCIENCE” could become in the years 2022–2023 press studies (more broadly media studies) focused on media addressed to women and their public perception. Attention should be given to the publications appearing in the 19th–20th-century traditional press as well as on the 20th–21st-century audiovisual media, both classic and digital. When examining their social perception, one should not forget about the use of spoken accounts that fit into the oral history research area, about egodocuments and intimism so important in biography, as well as about traditional and digital press photography.
Karma Hükümetten Denetim ve Dengeye Erkler Ayrılığı İlkesi The Principle of Separation of Powers from Mixed Government to Checks and Balances
Authors: DELİCE Aslan
Published: August 2022

Tarih boyunca en iyi yönetimin hangisi olduğu ve nasıl gerçekleştirileceği filozof ve hukukçuları hep meşgul etmiştir. Aristo’dan 17. asra kadar toplumun farklı kesimlerinin iktidara ortak edilmesine odaklanılmış, ılımlılık ve ölçüye dayanan, alt sınıflara iktidardan pay veren karma hükümetlerin en iyi devlet şekli olduğu kabul edilmiştir. 17. asırdan itibaren denge fikrinden uzaklaşılarak, mülkiyet ve özgürlükleri içeren burjuva kapitalist değerlerin korunması temel amaç haline getirilmiştir. Üç işlevin üç ayrı organa verilmesiyle oluşacak özgürlükler alanında kendini gerçekleştiren bireylerin refah ve adaletin kaynağı olacağı beklentisi, erkler ayrılığının kabulündeki asıl saiktir. Geniş halk kitlelerinin gerçekleşmeyen adalet ve refaha ilişkin hayal kırıklıkları modern negatif anayasacılık kurgusunun temellerinin sorgulanması için yeterli bir gerekçedir. Çalışma karma hükümetten farklı olarak erkler ayrılığının tüm kesimlerin değil sermaye sınıfının çıkarları doğrultusunda anayasal bir yapı oluşturduğu fikrine dayanır. TBMM’nin yürürlüğe koyduğu kanunlar da dahil olmak üzere hiçbir işleminin yargı denetimine tabi tutulmaması teklifi de halk adına egemenliği kullanan yasama organıyla diğerleri arasındaki bozulan dengenin yeniden tesisi için önerilmiştir.
Reflexiones sobre experiencias interculturales de estudiantes mapuches en la universidad: Dimensiones académicas y afectivas en proyección
Authors: Ortiz-Velosa Eliana Marcela , Riquelme-Mella Enrique , Gutiérrez-Saldivia Ximena
Published: August 2022

Introducción. La experiencia de formación académica de grupos minoritarios surge en un escenario de tensiones entre el sistema de educación predominantemente occidental y monocultural en relación con la educación familiar y saberes adquiridos por el estudiantado, así como la reproducción de diferentes formas de racismo. Estas tensiones han sido bien documentadas en la etapa escolar, mientras que en la formación universitaria de estudiantes indígenas de Chile han sido escasamente exploradas. Objetivo. Este estudio explora las creencias y representaciones de un grupo de estudiantes de origen mapuche respecto de sus experiencias académicas y socioafectivas de una universidad en Temuco, Chile, en el contexto de la Formación Inicial Docente inmersa en un sistema de educación que tradicionalmente ha sido monocultural. Metodología. El diseño metodológico se fundamentó en la investigación educativa y paradigma interpretativo, se entrevistaron a 12 estudiantes que se autoidentifican como indígenas mapuches, las entrevistas se analizaron a través de la técnica de codificación abierta. Resultados. Los principales resultados develan que las experiencias universitarias son diversas, y mantienen contenidos nucleares relacionados con la discriminación, lo que influye en la inserción y progresión en la formación profesional. Conclusión. El estudio permitió identificar las experiencias universitarias más satisfactorias, las que se relacionan con el posicionamiento del estudiantado respecto a su identificación cultural, la creación y mantenimiento de redes de apoyo.
Quantifying Effects of Final-State Interactions on Energy Reconstruction in DUNE
Authors: Sharma H.R. , Nagu S. , Singh J. , Singh R.B. , Potukuchi B.
Published: August 2022

In neutrino-nucleus interactions, the particles produced at the primary vertex may be different from the particles observed in the final state. This is due to the effect of final-state interactions (FSI) on the particles during their transport in the nuclear matter to reach the detector (final state) after their production at the primary vertex. In this report, the energy reconstruction is done for charged current quasielastic (CCQE) and charged current resonance (CCRES) scatterings on the event-by-event basis using the calorimetric method, and NuWro and GENIE simulation tools. In addition, the percentage of fake events in CCQE and CCRES interactions is presented. It is found that the percentage of fake events is more than 50% for both CCQE and CCRES processes for both the generators, if we apply the condition for the signal events that the particles observed in the final state should be the same as the particles produced at the primary vertex. Based on our definition of signal events, the reconstructed energy and number of fake events may change, and this influences the measurement of oscillation parameters in long-baseline experiments like DUNE.
Low-Field Feshbach Resonances and Three-Body Losses in a Fermionic Quantum Gas of 161Dy
Authors: Soave E. , Corre V. , Ravensbergen C. , Han J.H. , Kreyer M. , Kirilov E. , Grimm R.
Published: August 2022

We report on the high-resolution Feshbach spectroscopy on a degenerate, spin-polarized Fermi gas of 161Dy atoms, measuring three-body recombination losses at a low magnetic field. For field strengths up to 1 G, we identify as much as 44 resonance features and observe the plateaus of very low losses. For four selected typical resonances, we study the dependence of the threebody recombination rate coefficient on the magnetic resonance detuning and on the temperature. We observe a strong suppression of losses with decreasing temperature already for small detunings from the resonance. The characterization of complex behavior of the three-body losses of fermionic 161Dy is important for future applications of this peculiar species in research on atomic quantum gases.
Vascular Complications in Children Following Button Battery Ingestions: A Systematic Review
Authors: Akinkugbe Olugbenga , James Adrian L. , Ostrow Olivia , Everett Tobias , Wolter Nikolaus E. , McKinnon Nicole K.
Published: August 2022

CONTEXT

Children presenting to health care facilities with button battery (BB) impaction.

OBJECTIVES

To describe characteristics of children with vascular complications after BB impaction, as well as associated outcomes.

DATA SOURCES

National Capital Poison Center registry and PubMed database from inception to December 2021.

STUDY SELECTION

All reports describing children aged <18 years with vascular, esophageal, or airway complications after BB ingestion.

DATA EXTRACTION

We extracted characteristics including date of publication, age and sex of child, battery type and size, duration and location of impaction, complications, subsequent interventions, and interval between battery removal and death.

RESULTS

A total of 361 cases involved severe complications or death after BB ingestion (321 cases from the National Capital Poison Center registry database, 40 additional cases from PubMed). Nineteen percent (69 of 361) were fatal and 14% (51 of 361) involved vascular injuries. Three-quarters (75%) of vascular complications were aorto-esophageal fistulae and 82% of vascular injuries were not survivable. Fatal vascular cases had significantly longer median impaction time (96 hours versus 144 hours, P <.05) and a wider range of presenting features than survivors.

LIMITATIONS

The total number of cases with vascular complications was small, data reported varied between cases, and no data were available on overall exposure. Long-term morbidity data were not available for the survivors.

CONCLUSIONS

Prolonged BB impaction is a risk factor for vascular complications and death. A high index of suspicion is required for children representing with hematemesis after BB impaction, with prompt transfer to a tertiary center because vascular surgical intervention may offer a chance of survival.
Tropeirismo e educação
Authors: Muller Bruna Aldine , Castanha André Paulo
Published: August 2022

A Estrada de Palmas-Palmeira foi uma ramificação do Caminho das Missões, que buscava atender as necessidades comerciais decorrentes do grande tropeirismo do século XIX, possibilitando o trânsito de gado proveniente da região missioneira e dos Campos de Palmas, até o Caminho de Viamão. Nessa rota, até o ano de 1916 se constituíram os municípios paranaenses de Palmeira, Palmas, São João do Triunfo, União da Vitória, São Mateus e São Pedro de Mallet. Tendo em vista o desenvolvimento econômico, social e cultural dessa região, o presente texto, tem como objetivo analisar a relação entre tropeirismo e a escolarização no percurso da Estrada Palmas-Palmeira, no período de 1854-1916. A delimitação temporal tem início em 1854, por ser o marco inicial do governo na província do Paraná, quando o governo paranaense passou a organizar a instrução pública e demais setores. Já o recorte de 1916, marcou o acordo de limites entre os estados do Paraná e Santa Catarina. A metodologia adotada é a da análise de documentos oficiais, tendo como foco a legislação educacional, os relatórios dos presidentes de províncias, relatórios dos governadores do Estado, relatórios dos inspetores de instrução pública e professores, além de fontes bibliográficas. A pesquisa revelou que apesar das transformações socioculturais e econômicas decorrentes do tropeirismo na região, uma ampliação da escolarização só se deu com a colonização e o desenvolvimento de novas formas de trabalho.
Eficiencia de uso del agua en diferentes secuencias de cultivos y barbechos en Argentina
Authors: Golik Silvina , Chamorro Adriana M. , Bezus Rodolfo , Pellegrini Andrea , Voisin Axel
Published: August 2022

Introducción. El agua es el factor más limitante en la producción de cultivos extensivos en secano en la región pampeana de Argentina y de muchos lugares del mundo. Objetivo. Determinar la eficiencia de uso del agua, tanto en rendimiento en grano como en biomasa total producida, para diferentes secuencias de cultivos bajo distintos manejos de sus barbechos. Materiales y métodos. El ensayo se llevó a cabo en la Estación Experimental de la Facultad de Ciencias Agrarias y Forestales, J. Hirschhorn (34° 52´ LS, 57° 58´ LO), La Plata, Buenos Aires, Argentina, donde desde el año 2011 se trabaja con cuatro secuencias de cultivos y a partir del año 2015, en el período entre los cultivos de verano, se implementaron diferentes tratamientos que incluyeron el uso de cultivos de cobertura con y sin fertilización en el cultivo sucesor y la aplicación de compost. Durante el período 2015 - 2018 se determinó la biomasa total producida, el rendimiento y la eficiencia de uso del agua. Resultados. La secuencia avena (Avena sativa L.) / soja (Glicine max L.) 2da - maíz (Zea mays L.) - girasol (Helianthus annuus L.) - trigo (Triticum aestivum L.), resultó las más eficiente en el uso del agua. En último lugar, se encontró la secuencia trigo / soja 2da - soja - soja - trigo, con mayor frecuencia del cultivo soja. Los distintos tipos de barbechos afectaron la eficiencia de uso del agua, con valores menos eficientes bajo el tratamiento testigo. Conclusión. Las secuencias de cultivos analizadas presentaron diferencias en el uso del agua. Los barbechos con cultivos de cobertura y compost resultaron más eficientes en el uso del agua para grano en un 10,85 %, y para biomasa en un 3,64 % en promedio.
Literary Representations from the Border: The American Dream, Immigration and Identity
Authors: Gairaud Ruiz Hilda Virginia
Published: August 2022

Abstract

This article aims to compare and contrast the concepts of subjectivity represented in literature and constructed in borders: physical and imaginary geopolitical sites that have positioned identities in the margins throughout history. The comparative analysis examines the representation of marginal identities in literary texts, specifically those written by authors belonging to hyphenated cultures such as the Cuban-American Gustavo Pérez-Firmat (1994), “Bilingual Blues,” and Mexican-American Gloria Anzaldúa’s “La encrucijada,” among others, mentioned in the bibliography. The study shows that the portrayal of subjectivity and subalternity in literary texts contends with diverse discourses of power and hefty political structures that tend to repress and to delimit character’s development and conditions as human beings living in the United States.
Publicações na Revista Thema sobre Ensino de Química entre os anos de 2012 e 2022
Authors: Ribeiro Marcus Eduardo Maciel
Published: August 2022

A Revista Thema se apresenta como importante periódico de divulgação científica brasileiro e, no ano de 2022, completa 25 anos de lançamento de seu primeiro número. Esse artigo trata de uma investigação qualitativa que analisa as contribuições feitas nesta revista a respeito da temática Ensino de Química, buscando construir resposta para a seguinte pergunta: O que se mostra em publicações da Revista Thema entre os anos de 2012 e 2022 a respeito do Ensino de Química? Com esse objetivo, foi desenvolvida revisão sistemática de literatura em 28 produções encontradas, acompanhada de Análise Textual Discursiva. Emerge da análise a compreensão que as temáticas desses artigos podem ser divididas nas categorias Atividades Didáticas no Ensino de Química, a partir de 20 artigos identificados, e Formação de Estudantes e Docentes, com 8 produções. Como pontos que ainda podem sugerir novas publicações, percebem-se as questões sobre ensino inclusivo e discussões sobre materiais didáticos de Química, incluindo os livros didáticos, além da participação da Química nos itinerários formativos do novo ensino médio.
Palavras-chave: Ensino de Química; Revista Thema; Análise Textual Discursiva; revisão sistemática; metodologias de ensino.
Im Wald des Hippolytus •
Authors: Hogenmüller Boris
Published: August 2022

Pliny's Epistle 1.6 is a relatively short, apparently personal letter within the first book of Epistles, addressed to his friend Cornelius Tacitus. Besides intertextual references to Lucretius, Calpurnius Siculus and Tacitus, there is also an interesting allusion to Seneca's tragedy Phaedra, which influenced Pliny in the conception of the letter's frame story, as the present study aims to prove.
Glucose-assisted polyol synthesis of silver nanoplates and nanoprisms in the presence of oxyethylated carboxylic acid
Authors: Titkov Alexander A. , Borisenko Tatiana A. , Logutenko Olga A.
Published: August 2022

This work reports a simple route to synthesizing silver nanoplates and nanoprisms through a polyol approach in the presence of oxyethylated carboxylic acid and glucose. The resulting particles were characterized by electron microscopy and X-ray diffraction (XRD). The introduction of glucose and NaOH into the system substantially increases the yield of nanoplates and reduces their thickness. The optimized reaction conditions can be used to produce, in a one-pot synthesis, silver nanoplates and nanoprisms which may have applications as metallic fillers in ink and paste formulations for 2D and 3D printing to fabricate functional components and devices.
Repercussions of the labor reform on nursing work in the context of the covid-19 pandemic
Authors: Ferreira Ithana Queila Borges Pizzani , Santos Tatiane Araújo dos , Santos Handerson Silva , Mascarenhas Nildo Batista
Published: August 2022

ABSTRACT Objective: To reflect on the repercussions of the Labor Reform on nursing work during the COVID-19 pandemic. Methods: This is a reflective study based on the legal aspects of the Labor Reform in dialog with scientific productions pertaining to nursing work. Results: With the rise of the COVID-19 pandemic, the flexibilization of labor is being intensified, legally backed up by the Labor Reform. For nursing workers, the repercussions are felt in the work relationship, during the workday, in the salary, in union action, and in job protection. Final considerations: It is evident that, after the legislative changes, there’s no certainty that the flexibilization of labor and social security laws will bring favorable results in terms of economic growth, reduction of inequalities, and lower unemployment rates for the nursing workers. Therefore, the political organization of the professional categories is the way to overcome this scenario.
Manifestações de imagem da doença de von Hippel-Lindau: um guia ilustrado das manifestações abdominais
Authors: Fernandes Daniel Alvarenga , Mourão João Luiz Veloso , Duarte Juliana Ávila , Dalaqua Mariana , Reis Fabiano , Caserta Nelson Marcio Gomes
Published: August 2022

Resumo A doença de von Hippel-Lindau (VHL) é uma desordem autossômica dominante monogênica com mutações na linha germinativa do antioncogene VHL, no braço curto do cromossomo três (3p25-26). Afeta 1:36.000-50.000 indivíduos, com penetrância superior a 90% aos 65 anos de idade. Embora tenha início e apresentação variáveis, com pleiotropismo mesmo entre membros da mesma família que partilham uma mutação específica, usualmente manifesta-se de início em adultos jovens e predispõe ao desenvolvimento de tumores benignos e malignos no sistema nervoso central (SNC) e órgãos viscerais. Clinicamente, o diagnóstico pode ser realizado em uma das seguintes circunstâncias: a) em pacientes com história familiar de doença de VHL e pelo menos um dos tumores característicos relacionados à síndrome (como hemangioblastomas retinianos ou do SNC, carcinoma de células renais de células claras, tumores neuroendócrinos pancreáticos e tumores do saco endolinfático); b) dois ou mais hemangioblastomas do SNC; c) um hemangioblastoma retiniano ou do SNC mais pelo menos um tumor característico visceral relacionado à síndrome, excluindo-se cistos renais e epididimários. Nesse contexto, a imagem ocupa importante papel no diagnóstico e acompanhamento desses pacientes. Este ensaio iconográfico apresenta imagens características de manifestações abdominais de tumores relacionados à doença de VHL que todos os radiologistas devem conhecer.
Imaging manifestations of von Hippel-Lindau disease: an illustrated guide focusing on abdominal manifestations
Authors: Fernandes Daniel Alvarenga , Mourão João Luiz Veloso , Duarte Juliana Ávila , Dalaqua Mariana , Reis Fabiano , Caserta Nelson Marcio Gomes
Published: August 2022

Abstract Von Hippel-Lindau (VHL) disease is a monogenic autosomal dominant disorder with germline mutations of the VHL anti-oncogene on the short arm of chromosome 3 (3p25-26). It affects 1:36,000-50,000 individuals, with a penetrance greater than 90% at 65 years of age. Although of variable onset and presentation, with pleiotropism even among members of the same family who share a specific mutation, VHL disease usually manifests initially in young adults. It predisposes to the development of benign and malignant tumors of the central nervous system (CNS) and visceral organs. The clinical diagnosis of VHL disease can be made in the following circumstances: a) in patients with a family history of the disease and at least one of the tumors characteristic of it (e.g., retinal or CNS hemangioblastomas, clear cell renal cell carcinoma, pancreatic neuroendocrine tumors, and endolymphatic sac tumors); b) in patients with two or more CNS hemangioblastomas; c) or in patients with a retinal or CNS hemangioblastoma plus at least one visceral tumor characteristic of the disease, excluding renal and epididymal cysts. Imaging plays an important role in the diagnosis and follow-up of patients with VHL disease. This pictorial essay presents characteristic images of abdominal manifestations of VHL disease-related tumors that all radiologists should be aware of.
Análise de demonstrações financeiras de empresas do setor de saúde brasileiro (2009-2015): concentração, centralização de capital e expressões da financeirização
Authors: Andrietta Lucas Salvador , Monte-Cardoso Artur
Published: August 2022

O sistema de saúde brasileiro caracteriza-se pela grande participação do setor privado. Na presente década, as empresas que atuam em setores relacionados à saúde ganharam destaque no mundo corporativo pelos seus resultados e pela magnitude de suas operações financeiras. A trajetória das empresas foi analisada sob a ótica da financeirização, entendida como a disseminação de um padrão de acumulação característico do capitalismo contemporâneo. O objetivo deste artigo é analisar as expressões da financeirização na dimensão contábil-financeira das empresas e grupos econômicos do setor de saúde brasileiro. O estudo descreve a trajetória de rubricas e indicadores contábeis no período de 2009 a 2015, com base no levantamento das demonstrações financeiras de 43 empresas em cinco subsetores (planos de saúde, hospitais, varejo farmacêutico, indústria farmacêutica e serviços de apoio ao diagnóstico e à terapia). Os resultados são apreciados em quatro categorias: porte, desempenho, endividamento e relevância de aplicações financeiras. Esses resultados foram comparados com o conjunto das grandes empresas e das empresas de capital aberto no Brasil. O estudo evidencia aspectos centrais da financeirização, tais como o crescimento do setor, a expansão das empresas líderes e a centralização de capital, corroborando hipóteses ligadas à concentração e à centralização de capital. Outras hipóteses, como a relevância das aplicações financeiras nas receitas, não foram confirmadas. Por fim, os indícios fornecidos por uma análise estritamente contábil sugerem a necessidade de incorporar outras dimensões à análise, notadamente as estratégias de fusões, aquisições e outras operações patrimoniais.
Mudanças recentes e continuidade da dependência tecnológica e econômica na indústria farmacêutica no Brasil
Authors: Rodrigues Paulo Henrique de Almeida , Silva Roberta Dorneles Ferreira da Costa , Kiss Catalina
Published: August 2022

Este artigo apresenta os resultados de pesquisa sobre a indústria farmacêutica no Brasil, no período recente, realizada no âmbito do projeto multicêntrico Complexo Econômico-Industrial da Saúde, Inovação e Dinâmica Capitalista: Desafios Estruturais para a Construção do Sistema Universal de Saúde no Brasil. Os quatro componentes estudados sobre a evolução da indústria farmacêutica no Brasil foram: as políticas industriais do Estado; as mudanças na composição financeira e patrimonial das empresas de capital nacional, a evolução da produção; e o comportamento da balança comercial. As análises levaram em consideração o marco teórico proposto por Luiz Filgueiras e Reinaldo Gonçalves a respeito da implantação de um “modelo liberal e periférico” na economia brasileira a partir dos anos 1990. Foram levantados e analisados dados sobre: a situação das Parcerias de Desenvolvimento Produtivo (PDP) para medicamentos entre 2009 e 2020; da Pesquisa Industrial Anual (PIA), do Instituto Brasileiro de Geografia e Estatística (IBGE), entre 1996 e 2018; e os dados da evolução da balança comercial do setor entre 1996 e 2019. Os resultados evidenciam que a agenda do Estado para o setor favoreceu o crescimento da produção de medicamentos genéricos, dos medicamentos isentos de prescrição (MIP) e deu início a alguns projetos de transferência de tecnologia via PDPs para a produção de medicamentos biológicos e sintéticos. Apesar dessa evolução, o Brasil se mantém dependente da importação de insumos químicos e farmacêuticos e de medicamentos acabados. Isto nos mantém em situação de vulnerabilidade tecnológica e econômica em relação aos fornecedores mundiais, além de um aprofundamento do déficit da balança comercial do setor.
Complexo Econômico-Industrial da Saúde: a base econômica e material do Sistema Único de Saúde
Authors: Gadelha Carlos Augusto Grabois
Published: August 2022

O artigo tem como objetivo fazer uma discussão teórica e política do conceito do Complexo Econômico-Industrial da Saúde (CEIS), atualizando a visão para o contexto contemporâneo de transformação tecnológica e dos desafios para os sistemas universais de saúde e do Sistema Único de Saúde (SUS), em particular. Em um contexto de globalização assimétrica, de emergência de uma revolução tecnológica e de (re)colocação de barreiras estruturais que trancam a sociedade brasileira em seu movimento histórico de desigualdade, vulnerabilidade e exclusão, necessitamos repensar a saúde, retomando e atualizando uma agenda que privilegia os fatores histórico-estruturais da sociedade brasileira, a inserção internacional do País e sua relação com uma difusão extremamente assimétrica do progresso técnico, do conhecimento e do aprendizado, dissociados das necessidades sociais e ambientais locais. Mediante uma metodologia que envolve a análise da resposta brasileira à COVID-19, da balança comercial do CEIS e do acesso a vacinas para COVID-19, o artigo evidencia que a saúde é parte central da estrutura econômica e social e reproduz as características do padrão de desenvolvimento nacional em seu interior. Uma sociedade equânime, com qualidade de vida, comprometida com os direitos sociais e o meio ambiente é condicionada pela existência de uma base econômica e material que lhe dê sustentação. Essa visão sistêmica e dialética é a principal contribuição teórica e política pretendida pelo artigo, que procura contribuir para uma abordagem de saúde coletiva integrada com uma visão de economia política.
Dinâmica do capitalismo financeirizado e o sistema de saúde no Brasil: reflexões sob as sombras da pandemia de COVID-19
Authors: Braga José Carlos de Souza , Oliveira Giuliano Contento de
Published: August 2022

A pandemia de COVID-19 no Brasil explicitou a importância do Sistema Único de Saúde (SUS) e as limitações do sistema de saúde vigente no país, composto pelos setores público e privado, no contexto do capitalismo financeirizado em que instabilidades e crises típicas são estruturalmente determinadas. Nesse sentido, o artigo discute o sistema de saúde no Brasil sob a égide do capitalismo financeirizado e à luz da pandemia de COVID-19. Sustenta-se que a financeirização enquanto padrão sistêmico de riqueza potencializa processo de coisificação das relações socioeconômicas que é imanente a esse sistema, tornando indispensável o provimento dos serviços de saúde pelo Estado.
Peri-implant clinicoradiographic status among betel-quid chewers and controls
Authors: Alqutub Montaser N , Alali Yasser , Tulbah Huda I. , Javed Fawad , Vohra Fahim , Abduljabbar Tariq
Published: August 2022

Abstract The aim of the present case-control observational study was to evaluate the peri-implant clinicoradiographic status among betel-quid chewers and controls. Self-reported betel-quid chewers and controls were included. Participants were categorized into 3 groups: Group-1: Individuals chewing betel-quid with tobacco; Group-2: Individuals chewing betel-quid without tobacco; and Group-3: Controls (individuals not using tobacco in any form). Demographic data was collected using a questionnaire. Periodontal and peri-implant clinicoradiologic parameters (plaque and gingival indices [PI and GI], probing depth [PD] and crestal bone loss/marginal bone loss [CBL/MBL]) were assessed. Clinical attachment loss (AL) around teeth was also assessed. Group comparisons were done using the one-way analysis of variance and Bonferroni Post-hoc adjustment tests. Correlation of periodontal and peri-implant inflammatory parameters with the duration of betel-quid chewing habit and duration of placement in the mouth were assessed using logistic regression analysis. P<0.05 was considered statistically significant. Thirty, 30 and 30 patients were included in groups 1, 2 and 3, respectively. Full-mouth PI (P<0.01), GI (P<0.01), clinical AL (P<0.01), PD (P<0.01) and mesial and distal MBL (P<0.01) were higher in groups 1 and 2 than Group-3. Peri-implant mPI (P<0.01), mGI (P<0.01), PD (P<0.01) and MBL/CBL (P<0.01) were significantly higher in groups 1 and 2 than Group-3 with no significant difference in groups 1 and 2. Betel-quid chewing habit either with or without tobacco is a risk-factor of peri-implant soft-tissue inflammation and CBL.
MicroCT evaluation for CAD/CAM occlusal veneer fit using two materials and three cement space settings
Authors: Elbadawy Adel Abdelsattar , Omar Elsayed Ali , AbdElaziz Mohammed Hosny
Published: August 2022

Abstract This study was aimed to evaluate the fit of occlusal veneer restoration for two CAD/CAM materials with different cement space settings, using microCT scans. Sixty resin dies were made and divided into two groups (n=30) according to the materials, (I): Hybrid all-ceramic, and (II): zirconia-reinforced lithium silicate glass-ceramic. Each group was subdivided into three subgroups (n=10) according to the cement space parameters (30, 40, and 50 µm). Occlusal veneers for the six subgroups were milled. A circle with 20 different sections was placed at the center of every scanned specimen to measure four different locations (Occlusal, Axial, Marginal, and Absolute marginal discrepancy). Data were analyzed using two-way ANOVA at a 0.05 level of significance. There was no statistically significant effect of material type on the mean values of internal and marginal gaps for the three cement space parameters (P>0.05). There were no statistically significant differences in the occlusal and axial gap between the cement space parameters, furthermore, there were statistically significant differences in marginal gap distances and absolute marginal discrepancies (P>0.05). Hybrid all-ceramic showed smaller marginal and internal discrepancies than zirconia-reinforced lithium silicate glass-ceramic without statistically significant differences, and, for both materials, 50 µm cement space significantly improved the marginal fit and absolute marginal discrepancy.
Genetic, Cellular and Molecular Aspects involved in Apical Periodontitis
Authors: Petean Igor Bassi Ferreira , Silva-Sousa Alice Corrêa , Cronenbold Tamara Justiniano , Mazzi-Chaves Jardel Francisco , Silva Lea Assed Bezerra da , Segato Raquel Assed Bezerra , Castro Guilherme Assed Piedade de , Kuchler Erika Calvano , Paula-Silva Francisco Wanderley Garcia , Sousa-Neto Manoel Damião
Published: August 2022

Abstract The development, establishment and repair of apical periodontitis (AP) is dependent of several factors, which include host susceptibility, microbial infection, immune response, quality of root canal treatment and organism's ability to repair. The understanding of genetic contributions to the risk of developing AP and presenting persistent AP has been extensively explored in modern Endodontics. Thus, this article aims to provide a review of the literature regarding the biochemical mediators involved in immune response signaling, osteoclastogenesis and bone neoformation, as the genetic components involved in the development and repair of AP. A narrative review of the literature was performed through a PUBMED/MEDLINE search and a hand search of the major AP textbooks. The knowledge regarding the cells, receptors and molecules involved in the host's immune-inflammatory response during the progression of AP added to the knowledge of bone biology allows the identification of factors inherent to the host that can interfere both in the progression and in the repair of these lesions. The main outcomes of studies evaluated in the review that investigated the correlation between genetic polymorphisms and AP in the last five years, demonstrate that genetic factors of the individual are involved in the success of root canal treatment. The discussion of this review gives subsides that may help to glimpse the development of new therapies based on the identification of therapeutic targets and the development of materials and techniques aimed at acting at the molecular level for clinical, radiographic and histological success of root canal treatment.
REVERSE SURAL FLAP FOR LOWER LIMB RECONSTRUCTION
Authors: CLIVATTI GUSTAVO MOREIRA , NASCIMENTO BRUNO BAPTISTA DO , RIBEIRO RENAN DIEGO AMÉRICO , MILCHESKI DIMAS ANDRÉ , AYRES ARALDO MONTEIRO , GEMPERLI ROLF
Published: August 2022

ABSTRACT Introduction: Reconstruction of distal wounds in lower extremities can be challenging due to the lack of tissue to perform local flaps. Fasciocutaneous and muscular flaps are some options for coverage, such as the reverse-flow fasciocutaneous sural flap. Objective: To present an 18-month experience on ankle, calcaneus, and foot reconstruction using the reverse-flow sural flap, performed by the Complex Wounds Group of the Plastic Surgery Department of the University of São Paulo Medical School. Methods: An observational, retrospective and descriptive study was performed through data survey on medical records of all patients treated between November 2018 and June 2020. Results: Nine reverse-flow fasciocutaneous sural flaps were performed. All patients were men. The mean age was 38 years old. Five patients had acute wounds for traffic collision, one electrical trauma and three chronic post-traumatic injuries. The ankle was the most common injury site (6), followed by foot (2) and calcaneus (1). Four patients had complications, three of which were partial necrosis and one distal epitheliosis. No case of total necrosis was recorded. The average hospital stay was 30.1 days. Conclusion: The reverse-flow fasciocutaneous sural flap proved to be a viable, reproducible, and reliable option for distal lower limb reconstruction. Level of Evidence IV, Case Series.
EFFECTS OF HIP FLEXION CONTRACTURE ON SAGITTAL SPINOPELVIC PARAMETERS
Authors: PINHEIRO RÔMULO PEDROZA , DEFINO MATHEUS PIPPA , GARCIA FLÁVIO LUIS
Published: August 2022

ABSTRACT Objective: To assess the influence of hip flexion contracture on lumbar lordosis and spinopelvic parameters and the changes in these parameters after total hip arthroplasty (THA). Methods: Twenty adult patients with hip osteoarthritis were divided into two groups (ten patients with hip flexion contracture and ten without contracture). Patients were assessed preoperatively and six months after THA using the radiographic parameters sagittal vertical axis (SVA), lumbar lordosis (LL), pelvic incidence (PI), sacral slope (SS), and pelvic tilt (PT). Results: No statistical difference was found between pre- and postoperative LL values in the groups. After THA, both groups had increased PT and the group without hip flexion contracture had reduced SS. Conclusion: Patients with hip osteoarthritis and hip flexion contracture tend to have an increased LL in the orthostatic position compared to patients without contracture, but with no statistical significance. After THA, PT increased in both groups and SS decreased in patients without hip contracture. Studies should further investigate the role of hip flexion contracture on pelvic mobility and spinopelvic parameters to better understand these relations. Level of Evidence III, Case-Control Study.
INTERFERENCE OF EXTERNAL DAMAGE CONTROL FIXATION IN DEFINITIVE OSTEOSYNTHESIS
Authors: MUSSATTO JULIO CESAR DO AMARAL , BALSIMELLI FERNANDO , MUSSATTO GUILHERME DO AMARAL , ZAMBONI CAIO , CHRISTIAN RALPH WALTER , MERCADANTE MARCELO TOMANIK
Published: August 2022

ABSTRACT Introduction: Indications for provisional external fixation prior to the definitive treatment of fractures are associated with the control of local and systemic damage and the impossibility of definitive osteosynthesis in the emergency. Objective: To identify complications associated with external fixation prior to definitive internal osteosynthesis. Methods: This is a comparative, prospective study (Level II). Inclusion criteria: patients treated as emergencies (November 2019 and March 2020) who underwent provisional external correction followed by definitive osteosynthesis. We look for signs of inadequacies in external correction and correlation with infections (erythema, hyperemia, fistulae in the path of the pins or surgical scars), systemic symptoms of infection, and radiographic parameters for treatment up to eight weeks after surgery. Results: The average time for conversion to definitive osteosynthesis was 15.9 days and 47 lower limbs and three upper limbs were fixed. Of the participants who had deep infections, three (6%) showed signs during initial treatment (external fixator) and nine (18%), after definitive internal osteosynthesis. We found no correlation between provisional external correction and complications in the definitive treatment with osteosynthesis. Conclusion: The use of temporary external fixation before definitive internal osteosynthesis in fractures of the appendicular skeleton failed to increase complication rates even if the path of the implants in both procedures overlapped. Level of Evidence II, Comparative Prospective Study.