bluuebunny/crossref_metadata_2025 huggingface dataset:
Industrial Pollution Monitoring using LABVIEW and Arduino
Authors: Dadhania Kishan
Published: December 2021

Abstract: With the increase in the number of industries in the world today, it is important to keep the our environment healthy and no toxic for living creatures. This project concentrates on designing a pollution monitoring system for industries that would be detecting the toxic gases concentration in the atmosphere that is given out by chemical, paper, ammonia, etc producing industries. The system is designed to continuous monitor theconcentration of gases such as LPG, CO, Sulphur, chlorine etc. and warns if increasing level of toxic level of gases are detected. The values of the concentration of gases are logged into the excel file for future reference and perform analysis to understand the pattern of ejecting gases. This project uses Gas sensors and Arduino for detection and transmission of the data to Lab-VIEWsoftware for further process. Index Terms: Lab view, Gas sensors, monitoring, analysis,safety device
Synthesis and ADMET Study of Some 1, 8-Naphthyidine and Quinoline 3-Carboxylic Acid Derivatives
Authors: Gurjar Vinod Kumar
Published: December 2021

Abstract: The extremely drug resistant may be a worldwide public ill health in recent years. Molecules with newer targets and an alternate mechanism of action is an urgent requirement of improvement of latest drugs. The utilization of heterocyclic compounds has been increased dramatically over the last 70 years due to their wide selection of technical applications and their favorable environmental and toxicological properties The 1,8-naphthyridine and quinoline 3-carboxylic acid derivatives that we'll manufacture during this method will change the potency and specificity of fluoroquinolones. Taking under consideration the findings, the goal is to style and manufacture 1, 8-naphthyridine and quinoline 3-carboxylic acid derivatives. The synthesized compounds are going to be characterized using multiple analytical techniques, virtual screening, and in-silico ADME/T prediction. Keywords: 1, 8-Naphthyridine, Quinoline, ADMET, Heterocyclic Compound
Partial Replacement of Cement with Waste Paper Sludge Ash
Authors: Bashir Shahid
Published: December 2021

Abstract: Cement production is one of the sources that emit carbon dioxide, in addition to deforestation and combustion of fossil fuels also leads to ill effects on environment. The global cement industry accounts for 7% of earth’s greenhouse gas emission. To enhance the environmental effects associated with cement manufacturing and to constantly deplore natural resources, we need to develop other binders to make the concrete industry sustainable. This work offers the option to use waste paper sludge ash as a partial replacement of cement for new concrete. In this study cement in partially replaced as 5%, 10%, 15% and 20% by waste paper sludge ash in concrete for M25 mix and tested for compressive strength, tensile strength, water absorption and dry density up to the age of 28days and compared it with conventional concrete, based on the results obtained, it is found that waste paper ash may be used as a cement replacement up to 5% by weight and the particle size is less the 90µm to prevent reduction in workability. Keywords: slump test, Compressive strength, split tensile strength, water absorption test, Waste Paper Sludge Ash Concrete, Workability.
Jewish national units among the troops of Ataman G.M. Semyonov in the Transbaikal, 1919-1920
Authors: Kasatochkin Denis R.
Published: December 2021

This article is based on a wide range of sources, including documents of the Russian State Military Archive. It tells about a little-known national white counterrevolution formation created by Ataman G.M. Semyonov in early 1919 and recruited from the Jewish population of Transbaikalia. The uniqueness of this separate Jewish company lies in the fact that it was the only regular armed formation consisting of Jews and participating in combat action on the side of the White movement. In this way, at the very beginning of 1919, a detachment that included a Jewish company fought against the Red partisans and internationalists in the Yakut taiga on the Magyar rift. In addition, the Jewish divisions carried out garrison service in different settlements of the Semyonovskii kingdom. During the summer of 1919, underground Bolshevik cells began to form, which in the spring of 1920 led to a revolt in the white Jewish units. An insurrection in the village of Aleksandrovka was suppressed by Semyononvs forces. On 23 April 1920 a separate Jewish company in full strength successfully went over to the side of the Reds in the village of Nerchensky Zavod. In response, the Red command decided to create the 4th Rifle Partisan Regiment from among the Jewish partisans who had gone over to the Bolshevik side. Thereafter, this regiment was transformed into the 15th Infantry Regiment of the People's Revolutionary Army of the Far Eastern Republic. In the fall of 1920, it took part in heavy battles for Borzya and Dauria. All this is disclosed in more detail in this article. The Jewish national divisions were only one of the ethno-confessional units of the troops of ataman G.M. Semenov, next to Chinese, Serbian, Buryat, Mongolian, Caucasian and Tatar formations. Their activities in 1919 were mostly garrison work in nature, but they also had to fight against the partisans in extremely difficult conditions. The transition of these ethnic groups to the Reds was not surprising, at a time when the White movement in Transbaikalia was already in agony. The article also pays attention to the position of Jews in Transbaikalia during the Civil War and the attitude of Ataman G.M. Semenov to the Jewish matter.
Antimicrobial Susceptibility of Flavobacterium psychrophilum Isolated from Rainbow Trout (Oncorhynchus mykiss)
Authors: Uluköy Gülşen , Kubilay Ayşegül , Yıldırım Pınar , Duru Ahmet , Wiklund Tom
Published: December 2021

This study was conducted to determine antibiotic susceptibility of Flavobacterium psychrophilum isolated in diseased rainbow trout (Oncorhynchus mykiss) from two hatcheries in the Mediterranean region of Turkey. The samples were taken from the kidney and spleen for bacteriology from rainbow trout juveniles (weight 0.7-1 g) in April and isolates obtained on tryptone yeast extract salts (TYES) agar medium at 15°C for 72 hours. Fourteen isolates were identified as F. psychrophilum using biochemical, physiological, and morphological characteristics and API ZYM test. Antibiotic sensitivities of the isolates were determined by the disc diffusion method on TYES agar, and the results were evaluated according to CLSI standards. Only one isolate from each hatchery was used for the antibiogram test. Both isolates were sensitive to amoxicillin/clavulanic acid 2:1, penicillin, nitrofurantoin, florfenicol, amoxicillin, clindamycin, chloramphenicol, ampicillin, doxycycline, streptomycin, and erythromycin; resistant to sulfadiazine, sulfamethoxazole/trimethoprim, oxolinic acid, vancomycin, trimethoprim/sulfadiazine, gentamicin, kanamycin, nalidixic acid, oxacillin, enrofloxacin, flumequine, tobramycin. The results show that isolating F. psychrophilum and performing the antimicrobial susceptibility testing is important issue in disease control.
Nonclinical Time for Family Medicine Residency Faculty: National Survey Results
Authors: Jarrett Jennie B. , Griesbach Simon , Theobald Mary , Tiemstra Jeffrey D. , Lick David
Published: December 2021

Introduction: Recent changes to the Accreditation Council for Graduate Medical Education (ACGME) requirements eliminated minimum standards for protected nonclinical time for core faculty. Faculty perform many nonclinical tasks to maintain family medicine residencies. The objective of this study is to describe the landscape of nonclinical time for family medicine residency faculty.
Methods: Program directors at ACGME-accredited family medicine residencies were electronically surveyed in August 2019 to describe nonclinical time of their faculty. Survey information requested included program demographics, the amount of nonclinical time allocated, and the estimated amount of nonclinical time spent per year completing their faculty duties.
Results: A total 156 of 635 program directors (24.6%) returned the survey and 58 (9.1%) completed the entire survey for analysis inclusion. An average of 3,394 hours per year, per program were estimated to be spent on nonclinical activities. The greatest amount of time was spent on program administration (39%) and the least amount of time on curriculum development (5%). There was variation in the use of nonphysician faculty to complete these tasks. Allocated faculty time was comparable to estimated time spent performing nonclinical tasks. On average, a 24-resident program devoted 1.9 full-time equivalent faculty salary support to complete nonclinical activities.
Conclusions: Family medicine residency faculty spend significant time completing nonclinical tasks required to meet ACGME requirements and need the protected time to complete these necessary tasks. Direct data on the use of faculty nonclinical time is needed to more accurately define its use.
Cisto periodontal lateral e cisto odontogênico botrióide
Authors: Pezzi Luciana Paula Giacomet , Soares Eduardo Costa Studart , Filho Manoel Sant'Ana
Published: December 2021

Cystic jaw bone lesions have been largely studied and discussed since the beginning of their recognition. Although many of them have already been well-defined, some of them go on generating divergent opinions, such as the lateral periodontal cyst (LP C) and the botryoid odontogenic cyst (BOC). The objective of this article is to report two cases of unusual characteristics, one of them is about a lateral periodontal cyst and the other one is about a botryoid odontogenic cyst, presenting considerations as to their clinical, radiographic and histological aspects.
Instituições geriátricas e negligência odontológica
Authors: Melo Ana Lúcia Schaefer Ferreira de , Padilha Dalva Maria Pereira
Published: December 2021

Elderly abuse represents a whole of actions that include mistreatment, intentionally or not, or neglect against elder people. Mistreatment and neglect may be presence as restrictions, lack of basic care, poor hygiene, poor work conditions and lack of qualificated careers. Poor hygiene is the most serious problem of oral health on clependent elderly. In this population, oral hygiene must be provided. However, it has been constantly neglected, resulting in oral health collapse. Thc aim of this work is discuss some concepts and classify elderly abuse and neglect, list hypothesis of risk factors, review the legislation and identify the difficulties of caregivers. Furthermore, this study wants to stress the necessity of dentist's attention and responsibility of this issue. Dentists must be aware on this reality due to the high prevalence of oral health problems and needs in this group, emphasizing their social responsibility. Oral health care must be joined with the whole health attention, considering that quality of life of elderly people is strongly influenced by oral health conditions.
Restaurações atraumáticas : usos e limitações
Authors: Slavutzky Sonia Maria Blauth de
Published: December 2021

The Atraumatic Restorative Treatment are internationally known through their initials (A.R.T.) were recommended by the World Health Organization for dental caries treatment in places with no dental offices. Since then, other possibilities of use are appearing. This article presents a review of its uses and limitations in and out of the dental clinic.
Absenteísmo no atendimento clínico-odontológico: o caso do Módulo de Serviço Comunitário (MSC) do Centro de Pesquisas em Odontologia Social (CPOS) - UFRGS
Authors: Jandrey Circe Maria , Drehmer Tania Maria
Published: December 2021

A community dental service (MSC), integrating UFRGS Dentistry School is one of the fields where graduate students practice public health actions. The program is financed by Brazilian public health system (SUS), intending to offer dental treatment to schoolchildren from the area. Dentistry students promote educational and preventive actions at public schools and refer those who need curative interventions to MSC. The objective of this study is to identify the reasons for why schoolchildren/adolescents are absent in such dental treatment; fiftynine participants were interviewed, all of them regularly attending public schools covered by the program; among them, twenty-four were absent in dental treatment appointment; in addition to interviews, fourty-eight families were visited, including absents and presents, in order to better understand the reality faced by this population; qualitative and quantitative analyses were conducted showing that several reasons contribute to the phenomenon such as feelings like fear and anxiety, people's perceptions about health services and these people's beliefs and values of oral health; absenteeism was identified as part of a wider social process: the social deprivation which permeates all Brazilian society.
Principios del diseño curricular desde la complejidad: el caso de la Universidad Técnica Nacional
Authors: Toruño-Arguedas César
Published: December 2021

El presente ensayo realiza una propuesta de principios curriculares desde la complejidad para el caso de la Universidad Técnica Nacional (UTN), única universidad pública de Costa Rica con un Modelo Educativo sustentado en la complejidad. Para este fin, se realiza un abordaje teórico curricular y se integran los aportes de la complejidad a partir de los ejes transversales y principios de flexibilidad, integración, eclecticismo y calidad, incorporando elementos operativos para su implementación en los diseños curriculares. El ensayo permite concluir la existencia de lineamientos y principios operativos para el diseño curricular desde las premisas de la complejidad y permite establecer escenarios de investigación para otros elementos sustantivos del diseño, implementación y evaluación del currículo universitario.
Noncovalent Interactions of 1,4-Dithiafulvene and Nitroaromatics: A Combined DFT and Ab Initio Molecular Dynamics (AIMD) Study
Authors: Zhao Yuming , King-Poole Cody Marcus
Published: December 2021

The noncovalent interactions between a redox-active molecule,
phenyl-substituted dithiafulvene (Ph-DTF), and ten commonly encountered
nitroaromatic compounds (NACs) were systematically investigated by means
of density functional theory (DFT) calculations and ab initio molecular
dynamics (AIMD) simulations. Our modeling studies examined their 1:1
complexes in terms of equilibrium geometries, frontier molecular
orbitals (FMOs), nature of noncovalent forces, intermolecular charge
transfer (ICT), interaction energies and related energy decomposition
analysis. The computational results indicate that Ph-DTF can form
thermodynamically stable supramolecular complexes with
trinitro-substituted benzenes (e.g., 2,4,6-trinisuchtrotoluene and
picric acid), but its interactions with mono- and dinitrobenzenes do not
exhibit such stability. The selective binding properties are further
corroborated by AIMD simulations. Overall, this computational work
establishes a comprehensive understanding of the nature of noncovalent
interactions of Ph-DTF with various NACs, and the results can be used as
theoretical guidance for the rational design of selective receptors
and/or chemosensors for certain NACs that are of great concern in
current industrial applications and environmental control.
Métodos de fermentación del cacao nacional (theobroma cacao) y su influencia en las características físico-químicas, contenido de cadmio y perfiles sensoriales
Authors: Neira Mosquera Juan Alejandro , Revilla Escobar Karol Yannela , Aldas Morejon Jhonnatan Placido , Sánchez Llaguno Sungey Naynee
Published: December 2021

La presente investigación es parte del “Proyecto FOCICYT PFOC 5-14-2017 UTEQ” tuvo como objetivo determinar la variabilidad de tres tipos de cacao nacional (criollo, forastero y trinitario) y el efecto de los días de fermentación (día 1, día 3, día 4, día 5) considerando tres métodos (cajones en cascada, saco de yute, fermentación controlada) y dos zonas de cultivo (Vinces y Baba), además se realizó análisis del contenido de Cd. Para la evaluación de las características físico-químicas se empleó un diseño anidados con 12 tratamientos y 3 repeticiones. En cuanto a los perfiles sensoriales se utilizó un diseño A*B*C con 18 tratamientos y 3 repeticiones. Determinando que el método fermentación controlada – Vinces con el cacao Criollo obtuvo mejores resultados en pH almendra (5.20); pH testa (5.16) y acidez titulable (0,80). Considerando los días de fermentación, los mejores resultados fueron pH almendra: 6.35; 5.01; 5.18 y 4.94 en fermentación controlada - Baba. Para pH testa: 4.15; 4.44; 4.98; 5.57 en Cajones en cascada - Vinces.  Por consiguiente, acidez titulable en Fermentación controlada - Baba situó óptimos valores: 0,88; 1,51; 1.47; 0.82. De acuerdo al análisis sensorial el tratamiento Fermentación controlada + Criollo + Baba presentó mejores resultados en las categorías aroma (4), acidez (1.00), amargor (1.67), astringencia (1.00), pos gusto (3.67), calidad (8.88), resaltando los sabores: cacao, nuez, frutal, floral. El estudio de Cadmio demostró valores que no suponen ningún riesgo al consumidor en todos los tipos de cacao y sistemas de fermentación antes mencionados, siendo alrededor de < 0.01 mg/kg.
Morfología de la válvula aórtica bicúspide y dilatación aórtica
Authors: Durán A. Marco , Mendieta C. Paola , Freire B. Isabel
Published: December 2021

Introducción: la válvula aórtica bicúspide (VAB) es una de las cardiopatías congénitas más frecuentes y además de causar alteraciones en la función valvular, es común encontrar afectación de la arteria aorta. Metodología: estudio observacional, descriptivo y retrospectivo. En el servicio de consulta externa del hospital Roberto Gilbert se revisaron los registros ecocardiográficos de pacientes con diagnóstico de VAB entre abril 2017 y abril 2019. Resultados: de 8.000 registros ecocardiográficos revisados se encontraron 71 niños con el diagnóstico de VAB dando una prevalencia del 0,9% con una clara superioridad del sexo masculino (76,4%). Lesiones funcionales valvulares se registraron en el 55,55% de la población sin que se encuentre predominancia de la estenosis o de la insuficiencia. La dilatación aórtica se encontró en 24 pacientes (33%) siendo el segmento de los senos de Valsalva, el mayormente afectado. Conclusiones: la prevalencia de VAB en el presente estudio se encuentra entre los valores publicados. Es frecuente la presencia de lesiones valvulares y dilatación de la aorta. Después del diagnóstico, la vigilancia y el seguimiento se vuelven muy importantes para prevenir eventos catastróficos y el momento del tratamiento intervencionista. Se recomienda descartar VAB en familiares de primer grado.
The Effectiveness of Online Based Learning in Universities During the Covid-19 Pandemic
Authors: Dwikurnaningsih Yari , Waruwu Marinu
Published: December 2021

The Covid-19 pandemic has had an impact on the management of learning in universities. Face-to-face learning has shifted to online-based learning. This study aims to analyze the effectiveness of online-based learning in higher education in terms of aspects of planning, implementation, evaluation, constraints and strategies towards new habits. The research method used quantitative-qualitative descriptive. Data collection techniques used interviews and open-closed questionnaires, the results of which were processed qualitatively by using Miles and Huberman's qualitative data analysis model and quantitative data analysis using mean, categorization and percentage calculations. The population of this study was 1,117 students, while the sample was taken randomly as many as 366 people. Interviews were conducted on 9 lecturers. The results of this study indicate that 1) planning, implementation and evaluation of online based learning get an assessment with a good category, 2) online based learning obstacles can be overcome with a blended learning model strategy, practical courses are carried out face-to-face, choosing materials and courses online, online learning is done through virtual face-to-face, attitude assessment using various instruments, and lecturers giving assignments according to the number of credits for the course. Thus, online based learning in higher education needs to be improved through blended learning models, face-to-face practical courses, attitude assessment instruments with various alternatives, selection of materials and courses online or offline and assignments according to the number of credits.
Improving High-Level Thinking Skills in Students Through Powtoon-Based Animation Video Media
Authors: Rahmawati Fahni , Ramadan Zaka Hadikusuma
Published: December 2021

Students are less able to optimize higher-order thinking skills. There are still many students who are confused in working on problems related to higher thinking skills. This paper provides a template for preparing papers for electronic production of the Journal of Education Technology. A well-prepared abstract enables the reader to identify the basic content of a document quickly and accurately, to determine its relevance to their interests, and thus to decide whether to read the document in its entirety. The Abstract should be informative and completely self-explanatory, provide a clear statement of the problem, the proposed approach or solution, and point out major findings and conclusions. The Abstract should be 150 to 250 words in length. The abstract should be written in the past tense. Standard nomenclature should be used and abbreviations should be avoided. No literature should be cited. The keyword list provides the opportunity to add keywords, used by the indexing and abstracting services, in addition to those already present in the title. Judicious use of keywords may increase the ease with which interested parties can locate our article.
DAMPAK PANDEMI COVID-19 TERHADAP PERILAKU KONSUMSI PARIWISATA: STUDI EMPIRIS PADA WISATAWAN DOMESTIK INDONESIA
Authors: Andriani Lis , Ramelan Muji Rahmat , Fihartini Yuniarti
Published: December 2021

Pandemi Covid-19 berdampak pada seluruh sektor ekonomi, diantaranya industri pariwisata dan pendukungnya. Pandemi mengubah pandangan masyarakat terhadap perjalanan wisata, perilaku dalam pemilihan destinasi wisata, dan penentuan keputusan pengkonsumsiannya. Sementara keberlangsungan industri pariwisata sangat bergantung pada arus wisatawan dan persepsi individu wisatawan.

Penelitian ini menganalisis sikap wisatawan terkait faktor kebersihan dan keamanan, menganalisis perilaku wisatawan dalam pengkonsumsian pariwisata, serta melihat potensi pariwisata baik saat pandemi maupun setelah pandemi Covid-19. Penelitian ini dilakukan dengan metode survei melalui kuesioner secara online terhadap 353 responden. Pengujian hipotesis dilakukan dengan teknik statistik deskriptif one sample t-test menggunakan SPSS.

Hasil analisis menunjukkan bahwa seluruh hipotesis dalam penelitian ini dapat didukung. Wisatawan menilai sangat penting menerapkan protokol kesehatan pada masa pandemi. Pandemi tidak menghentikan minat wisatawan untuk melakukan perjalanan wisata, namun wisatawan cenderung menunda rencana perjalanan ke destinasi dengan infeksi virus Covid-19 tinggi. Wisatawan menghindari destinasi yang ramai, memilih wisata kuliner dan objek wisata luar ruang yang lokasinya dekat wilayah tempat tinggal, dan menghindari perjalanan berkelompok. Objek wisata orisinal berbasis alam (ekowisata, maritim, bahari) maupun berbasis pertanian (agrowisata) yang menawarkan privasi dan customisasi dinilai memiliki potensi dikembangkan saat pandemi maupun setelah pandemi Covid-19.

Kata Kunci: Destinasi wisata, konsumsi pariwisata, perilaku wisatawan, kebersihan dan keamanan
DESAIN ALAT BANTU ERGONOMIS DI DEPO PASAR IKAN KOTA TASIKMALAYA
Authors: Eldrin Gheva Julian , Sarvia Elty
Published: December 2021

Depo Pasar Ikan merupakan penyedia jasa pemasaran ikan, dalam pengelolaannya masih dilakukan secara manual pada proses angkut dan penurunan ikan, sehingga menimbulkan proses pengulangan yang cukup banyak. Tujuan dilakukannya penelitian ini adalah agar terciptanya proses bongkar muat yang lebih mudah dengan penggunaan alat bantu ergonomis, sehingga para pedagang lebih mudah dalam pengangkutan dan pemindahan ikan. Penelitian ini diawali dengan observasi lapangan, wawancara, pengumpulan data seperti kapasitas angkut, dan dimensi plastik  kemudian menganalisis data. Dari pengolahan data dan analisis, terbukti bahwa masih ada pengulangan yang banyak pada proses penurunan maupun pengangkutan. Untuk itu, perlu adanya alat bantu berupa Trolley Lifter yang digunakan agar bongkar muat menjadi lebih mudah dan cepat.Trolley lifter ini di rancang sesuai dengan kebutuhan pengangkutan, memiliki kelebihan yaitu dapat mengurangi proses pengulangan angkut juga dapat mengurangi beban pada saat perpindahan ikan yang dilakukan oleh penjual, dan berdasarkan analisis data antropometri agar proses penggunaannya menjadi lebih mudah dan nyaman.  Kata Kunci : Proses Pengulangan, Bongkar Muat, Alat Bantu, Antropometri
Information technology in the evaluation of RWD / RWE (Real-World Data / Real-World Evidence)
Authors: Zhukova OV , Khokholov AL
Published: December 2021

The features of evaluating data from real clinical practice are discussed. Approaches to material processing for decision support in medicine and health care are also given. The development of standardized methods of analysis with the possibility of obtaining a unified indicator for assessing data from routine clinical practice, combined with the development of information technology is the direction of development of the concept of result-oriented health care. The classification of information technologies used in medicine and public health is presented. The main characteristics and functioning features of the developed software modules for automated data evaluation of real clinical practice are presented: a program for the distribution of drugs on the levels of clinical efficacy, a program to assess the effectiveness of therapy for the specified period; a program to determine the interval of clinical efficacy of drugs.
Komoditi Lada dan Praktik Kapitalisme di Sumatera Selatan Pada Abad XVIII - Awal Abad XX
Authors: Novita Aryandini , Fahrozi Muhamad Nofri , Alnoza Muhamad
Published: December 2021

Pepper (Piper nigrum) is one of the cultivated plants and since the past has become a commodity traded in international commerce. In the past several regions of the archipelago have cultivated pepper, such as Banten, southern Sumatra, and Aceh. This paper aims to describe the ebb and flow of pepper as a trading commodity during the 18th to early 20th centuries concerning the practice of capitalism in the South Sumatra region. The method of articles is a literature study with data sources the result of archaeology research and history research as well as other library data related to pepper as commodities in the South Sumatra region during the 18th century to the early 20th century. The results showed that colonialism had encouraged pepper production in South Sumatra on a large scale. However, along with changes in global market demand, there has been a change in the orientation of the cultivation of commodity crops so that it can be said that colonialism also brought down pepper production.
Structure-Based Virtual Screening and Molecular Dynamics of Quercetin and Its Natural Derivatives as Potent Oxidative Stress Modulators in ROS-induced Cancer
Authors: Umar Abd. Kakhar , Zothantluanga James H.
Published: December 2021

Quercetin derivatives are known to have significant anticancer activity. The activity is strongly influenced by the type and position of the substituent group. By studying the structural pattern of quercetin and its impact on their binding affinity, the development of quercetin-based drugs can be optimized. The study aimed to determine the impact of 3D structure, type, and position of quercetin moiety on its activity against ROS-modulating enzymes that play a role in the induction and growth of ROS-induced cancer. The 23 natural quercetin derivatives were docked to 7 ROS-modulating enzymes using Autodock Vina to determine their binding affinity and interaction. The interaction stability was further studied through molecular dynamics simulation using the CABS Flex 2.0 server. Determination of crucial amino acid targets of the quercetin group was determined using DockFlin. Finally, the toxicity of each test ligand was determined using the pkCSM server. The highest binding affinity for SOD and NOX was produced by quercetin 3'-glucoside with the binding energy of -10.2 and -12.8 kcal/mol. Quercetin 3,4'-diglucoside had the highest binding affinity for CAT and GR at -11.5 and -10.5 kcal/mol, respectively. Routine produced the highest binding affinity at LOX (-10.9). Quercetin 3-O-xyloside and quercetin 3-O-rhamnoside-7-O-glucoside had the highest binding affinity in XO with a value of -10.4 kcal/mol. The glucose and prenyl groups are beneficial for quercetin in interacting with all ROS-modulating enzymes except XO. In contrast, the methoxy group negatively affects all interactions of quercetin with receptors. The perfect fit between the binding pocket and the 3D structure of the ligand greatly benefits the ligand in accessing more amino acids in the binding pocket. Their interaction stability and toxicity show that quercetin 3'-glucoside, quercetin 3,4'-diglucoside, and rutin are potent oxidative stress modulators in treating ROS-induced cancer.
Komunikasi pariwisata dalam pengembangan destinasi wisata di Kecamatan Kuok Kabupaten Kampar
Authors: Yasir Yasir
Published: December 2021

Pariwisata merupakan industri yang berkembang pesat secara global dan saat ini menjadi sumber pekerjaan dan mata pencaharian bagi banyak orang. Pembangunan pariwisata di daerah sebagai salah satu sektor pembangunan tidak dapat dilepaskan dari pembangunan masyarakat lokal dan pembangunan fasilitas pendukungnya. Salah satu faktor keberhasilan pengembangan sebuah destinasi wisata adalah komunikasi. Melalui komunikasi peluang keterkenalan suatu destinasi wisata akan terbuka semakin lebar dikenal oleh masyarakat luas. Penelitian ini bertujuan untuk menguraikan komunikasi pariwisata dalam pengembangan destinasi wisata dan menjelaskan partisipasi masyarakat dan memahami model perencanaan komunikasi pariwisata dalam pengembangan destinasi wisata di Kecamatan Kuok Kabupaten Kampar. Penelitian ini menggunakan metode kualitatif. Hasil penelitian menunjukkan bahwa komunikasi pariwisata pemerintah Kabupaten Kampar dalam mengembangkan destinasi wisata adalah dengan membentuk beberapa desa wisata, membina kelompok sadar wisata (Pokdarwis), dan mengembangkan partisipasi masyarakat pada daerah destinasi wisata yang melibatkan stakeholder pemerintah dan akademisi melalui pengabdian masyarakat. Simpulan penelitian menunjukkan bahwa Komunikasi pariwisata dalam pengembangan destinasi wisata Pulau Belimbing Kecamatan Kuok di Kabupaten Kampar dilakukan dengan cara membina dan memberdayakan kelompok sadar wisata (Pokdarwis), melibatkan partisipasi masyarakat sekitar destinasi wisata, dan kampanye wisata yang mengusung tema Wisata Agro-Cultural. Adapun saran nya adalah sebaiknya perencanaan komunikasi pariwisata di kawasan destinasi wisata Pulau Belimbing sebaiknya pemerintah mengembangkan komunikasi yang lebih kreatif, terintegrasi dan berkelanjutan dalam melakukan pembinaan menyesuaikan pada aspirasi masyarakat setempat.
Functional tooth units and masticatory ability in elderly population
Authors: Dwiningrum Fatimah Rini , Sari Kartika Indah , Rikmasari Rasmi
Published: December 2021

Introduction: The elders are the ones that most often experience tooth loss which affects masticatory function. Masticatory function can be evaluated subjectively through masticatory ability assessment. The masticatory function is influenced by the number of posterior occluding pairs; this also may be called as functional tooth units (FTUs). The purpose of this study was to describe FTUs and masticatory ability in the elderly. Methods: This research was a descriptive study with a cross-sectional study design. Subjects were taken by purposive sampling technique. The study was conducted in the Lebakgede Sub-district, Bandung City. Data mentioned were obtained by conducting interviews regarding data on subject characteristics and questionnaires of masticatory ability, as well as examining the oral cavity to obtain FTUs data. Results: Subjects obtained were 74 people consisting of 63 women (85.14%) and 11 men (14.86%). Based on the results, the average age of the research subjects was 68.49 years, and those with good masticatory ability status were 26 elderly (35.14%) with an average FTU value of 5.9 while 48 elderly (64.86%) had poor masticatory ability status with an average FTU score of 1.5, even 31 subjects (41.89%) had a zero FTU score. Conclusion: The majority of the elderly in this research mostly had a low total FTUs score which means that the masticatory ability status in the elderly tended to be poor.
Manajemen Perioperatif Gejala Ekstrapiramidal (EPS) pada Hidrocephalus Tekanan Normal (NPH)
Authors:   Department of Anesthesiology and Intensive Care, Kasih Ibu General Hospital Bali, Indonesia, Baratha Suyasa Agus , Dharmi Lestari Ni Putu ,   Department of Anesthesiology and Intensive Care, Kasih Ibu General Hospital Bali, Indonesia
Published: December 2021

Extrapyramidal symptoms (EPS) are movement disorders due to side effects of dopamine receptor blocking agents. Symptoms of EPS include dystonia, akathisia, and parkinsonism. Symptoms of EPS in this case are found in normal pressure hydrocephalus (NPH) which does not consume dopamine receptor blocking drugs. Normal pressure hydrocephalus is hydrocephalus which does not coincide with intracranial pressure (ICT) elevation. Reported a case of a 57-year-old male with decreased consciousness and extrapyramidal symptoms and Normo pressure hydrocephalus (NPH), a V-P Shunt operation was performed. The operation was carried out under general anesthesia, using a non-kinking ETT no. 7.5, controlled ventilation. Premedication given midazolam 2 mg iv, Co induction with oxycodon 10 mg iv. Induction with propofol 150 mg iv, intubation facilities with rocketuronium 30 mg iv, maintenance with O2: Air (50: 50), sevoflurane, propofol continuous 100 mg/hour, rokuronium 20 mg/hour. Stable hemodynamics, SBP 130–150 mmHg, DBP 80–90 mmHg, HR 50–70 x/min, O2 saturation 99–100%, etCO2 35–37. After surgery the patient was treated in the intensive care unit (ICU) for monitoring blood pressure and extrapyramidal symptoms. The main goal of treatment should not be solely for the treatment of acute symptoms of EPS but also for the management of basic disease causing EPS related to morbidity and maintaining quality of life. Multidisciplinary management (neurosurgery, neurosurgery, intensive anesthesia and medical rehabilitation) are needed for better long-term results.
A Case Report on Mephentermine Induced Psychosis with Acute Liver & Kidney Injury
Authors:   Resident, Deparment of Psychiatry, Agartala Govt. Medical College and GBPH Hospital, Agartala, Tripura, India, Debnath Manjulika
Published: December 2021

Background: Mephentermine is a sympathomimetic agent derived from methamphetamine. It is a commonly used drug for the treatment of hypotension during anaesthesia. Its abuse has markedly increased especially in the young population due to its stimulant properties and ability to boost performance in competitive sports or bodybuilding. Very few cases of Mephentermine dependence with or without psychosis have been reported from India and worldwide. Case Description: A 24-year-old male presented with a sudden onset of behavioural abnormalities a few hours following the use of Mephentermine. He was very agitated and restless. On physical examination, tachycardia, elevated BP and bilaterally dilated pupils were found. His symptoms remitted within a few hours of using Injection Haloperidol 10 mg with Lorazepam 4 mg once. He was found to have grossly deranged liver and kidney function tests. There was no past and family history of any psychiatric illness. No past history of any physical illness. Conclusion: No previous report of mephentermine induced psychosis with acute kidney and liver injury has been reported in the literature. Cases such as this may be common among the general public. Long term follow-up is required to know the course and outcome in such unusual cases.
Dexmedetomidine prolongs the duration of action of mepivacaine on anesthesia of the palmar digital nerves of horses
Authors: Nichols Cailey L. , Doherty Thomas J. , Schumacher James , Jones Philip D. , Sun Xiaocun
Published: December 2021

OBJECTIVE

To determine whether palmar digital nerve (PDN) blockade in horses with a combination of dexmedetomidine and mepivacaine would block the response to mechanical force applied to the digit longer than would anesthetizing these nerves with mepivacaine alone or dexmedetomidine alone.

ANIMALS

8 mares with no signs of lameness.

PROCEDURES

In a randomized, crossover, blinded, experimental study, both PDNs of the same forelimb of each horse were anesthetized by perineural injection with either 30 mg mepivacaine alone, 250 µg of dexmedetomidine alone, or 30 mg mepivacaine combined with 250 µg of dexmedetomidine. Each horse received each treatment, and treatments were administered ≥ 2 weeks apart. The mechanical nociceptive threshold was measured at a region between the heel bulbs with the use of a digital force gauge before (baseline) and at 15-minute intervals after treatment.

RESULTS

The mean duration of sensory blockade of the digit was 2-fold longer when a combination of mepivacaine and dexmedetomidine was administered (371 minutes), compared with when mepivacaine alone was administered (186 minutes). Treatment with dexmedetomidine alone did not change the mechanical nociceptive threshold substantially from baseline and resulted in no clinical signs of sedation.

CLINICAL RELEVANCE

Results indicated that relief from digital pain provided by perineural treatment with mepivacaine for PDN blockade can be extended by adding dexmedetomidine to the injectate.
МЕЖДУНАРОДНО-ПРАВОВЫЕ ПРОБЛЕМЫ ГОСУДАРСТВ, ВХОДЯЩИХ В СНГ
Authors: Блищенко И. П.
Published: December 2021

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НАДНАЦИОНАЛЬНОСТЬ С ТОЧКИ ЗРЕНИЯ МЕЖДУНАРОДНОГО ПРАВА
Authors: Королев М. А.
Published: December 2021

Отечественное правоведение уже не раз обращалось к теме наднациональности, ей посвящен рад обстоятельных исследо­ваний. Не стремясь к исчерпывающему охвату данной проблемы,в настоящей статье мы попытаемся рассмотреть некоторые относя­щиеся к ней вопросы общего характера.
ОДНА ИЗ ГЛОБАЛЬНЫХ ЗАДАЧ
Authors: Соколова Н. А.
Published: December 2021

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К ВОПРОСУ ОБ «ОБХОДЕ ЗАКОНА»
Authors: Муранов А. И.
Published: December 2021

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МЕЖДУНАРОДНО-ПРАВОВЫЕ АСПЕКТЫ ПРИМЕ­НЕНИЯ НОРМ ВАЛЮТНОГО КОНТРОЛЯ
Authors: Шамсиев Х. Р.
Published: December 2021

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Comparative studies on the microstructure and corrosion
behaviour of forged and SLM processed 316L stainless steel
Authors: Woelk Dino , Kazamer Norbert , Mărginean Gabriela
Published: December 2021

The corrosion behaviour of forged and SLM (Selective Laser Melting) processed 316L samples was investigated in a 3.5% NaCl solution at neutral and light acidic pH. The influence of the oxygen concentration in the testing solution on the corrosion resistance of the alloy was also proved.
This made it possible to qualitatively evaluate the influence of the additive manufacturing process on the microstructure of the 316L alloy in comparison to that of the forged steel. Therefore, the logarithmic polarisation curves generated during the electrochemical investigations were compared, especially in respect to the corrosion potential respectively corrosion current density. The results showed that the corrosion resistance of the 3D-printed samples was inferior to that of the forged 316L.
Instead of the pitting corrosion that often appears during exposure of the forged material to chloride containing media, the SLM processed material exhibited rather an extensive surface attack. The microscopic examination of the samples revealed large differences in porosity between the microstructures obtained by means of the two manufacturing methods, whereby the 3D-printed samples exhibited a larger number of voids.
Intelligent Approaches for Enhancing Networked Routing Protocol
Authors: Yas Ruwaida M. , Hashim Sokaina
Published: December 2021

The rapid evolution of wireless networking technologies opens the door to the evolution of the Wireless Sensor Networks (WSNs) and their applications in different fields. The WSN consists of small energy sensor nodes used in a harsh environment. The energy needed to communicate between the sensors networks can be identified as one of the major challenges. It is essential to avoid massive loss, or loss of packets, as well as rapid energy depletion and grid injustice, which lead to lower node efficiency and higher packet delivery delays. For this purpose, it was very important to track the usage of energy by nodes in order to improve general network efficiency by the use of intelligent methods to reduce the energy used to extend the life of the WSN and take successful routing decisions. For these reasons, designing an energy-efficient system that utilizes intelligent approaches is considered as the most powerful way to prolong the lifetime of the WSN. The proposed system is divided into four phases (sensor deployment phase, clustering phase, intra-cluster phase, and inter-cluster phase). Each of these phases uses a different intelligent algorithm with some enhancements. The performance of the proposed system was analyzed and evaluations were elaborated with well-known existing routing protocols. To assess the proficiency of the proposed system and evaluate the endurance of the network, efficiency parameters such as network lifetime, energy consumption, and packet delivery to the Sink (Base station) were exploited. The experimental outcomes justify that the proposed system surpasses the existing mechanisms by 50%.
ENGLISH LANGUAGE TEACHERS' PRACTICES OF DEVELOPING DISCOURSE COMPETENCE THROUGH SPEAKING SKILLS FOR GRADE 10 STUDENTS: A CASE STUDY
Authors: Hai Ha Vu , Uyen Nguyen Nha
Published: December 2021

Being one of the compulsory foreign languages in Vietnam and recently regarded as one of the requirements for higher education enlistment, English has received growing attention from Vietnam high school students (Nguyen, 2021). In Circular 32 (2018), the Vietnam Ministry of Education and Training [MOET] officially recognised communicative competence as the primary outcome of the English National Program of which Discourse Competence (DC) is a crucial component (MOET, 2018). Although the program aims to achieve the outcome with more emphasis on listening and speaking skills, Vietnamese high school students remain to struggle to form extended spoken discourse (Le, 2011). With the view to gaining insights into the actual state of cultivating DC through speaking skills in students, the study investigates four Grade 10 teachers with varied backgrounds and teaching styles in a private school awarded twice by the MOET for educational reforms and their attempts to integrate CLT in the English language teaching curriculum. After conducting the interviews and classroom observation, the findings imply that teachers devised a combination of approaches that had implicit impacts on different aspects of DC-based on students' English proficiency while preserving their teaching philosophies. Such innovativeness could suggest a rudimentary framework for teaching and teacher training programs regarding fostering DC in speaking for EFL students.
A Cross-Cultural Study of Relationships between Epistemological Beliefs and Self-Regulated Learning Strategies
Authors: Jiang Ying Hong , Wang Jia , Bonner Patricia , Yau Jenny
Published: December 2021

Introduction.  Prior research consistently provides evidence supporting potential relationships between epistemological beliefs and learning. The current study examines the relationship between epistemological beliefs, academic motivation, and self-regulated learning strategies among different ethnic groups of American adolescents.
Method.  This quantitative study utilized a correlational design to examine the relationship between epistemological beliefs and self-regulated learning strategies in adolescents attending middle school. A total of 364 middle school students (6th to 8th grade) from Southern California public middle schools participated in the study. A multiple group path model was employed to analyze the student data.
Results.  We found that certain knowledge, omniscient authority, and innate ability beliefs about the nature of knowledge predict positive relationships with self-efficacy and intrinsic value components of motivation. Quick learning and simple knowledge beliefs predict negative relationships with self-efficacy and intrinsic-value but positive relationship with test-anxiety. Similarly, in the aspect of self-regulatory learning strategies, those who believe in the absolute nature of knowledge and the authorities tend to use cognitive and self-regulatory learning strategies more often, while those who believe in the speed of knowledge acquisition tend to employ those strategies less.
Discussion and Conclusion. Findings from this study inform educators of the need to advance adolescents’ epistemological beliefs for each subject (e.g., science, language arts) as a method to facilitate their motivation and self-regulated learning. We recommend that future research should include assessments of the participants’ cultural orientations or the domain specificity of the epistemological beliefs, which may vary the associations of the beliefs with self-regulated learning. Additionally, future research can further investigate other potential mediators of the relationship between epistemological beliefs and self-regulatory learning.
Attitudes towards gender equality and coeducation among Secondary School teachers: a case of study in Madrid, Spain
Authors: Jular-Alba Raquel , Martín-Ramos Clara , Martín-Ramos Pablo
Published: December 2021

Introduction. In spite of the education reform and the introduction of mixed schools, there are still obstacles to gender equality in Spain. Sexist attitudes and values continue to influence personal development and career choices, limiting women's participation in all areas. The opinions, beliefs, ideas, conceptions, expectations and personal attitudes of teaching professionals exert a great influence on the students who perceive them, which calls for up-to-date information on teaching staff’s perceptions towards gender equality and coeducation.Method. In this work, results from a survey distributed in three Secondary Schools in the Autonomous Community of Madrid, with 105 participants, are presented. The retrieved data were analyzed by using ANOVA and Kruskal-Wallis non-parametric tests.Results. Significant differences were found among the respondents in terms of their views on gender equality for the gender and gender*age factors, and for the gender and years of teaching experience factors in the case of their perceptions about coeducation.Discussion and conclusion. Although the tendency toward a true status of equality was more pronounced in women than in men, an adequate predisposition on the majority of teachers of both sexes towards the achievement of a social equality model based on the promotion of peer roles and coeducational practices was found.