bluuebunny/crossref_metadata_2025 huggingface dataset:
Revolucionarios, rebeldes y contrarevolucionarios. Un análisis comparativo entre Chile y el Cuzco, 1812-1816
Authors: Ossa Santa Cruz Juan Luis
Published: March 2023

El año 1814 fue clave en el devenir de la guerra civil revolucionaria que azotó a los actuales territorios chileno y peruano a raíz de las abdicaciones monárquicas en Bayona. Durante ese año, el virrey peruano José Fernando de Abascal logró frenar las aspiraciones autonomistas de los revolucionarios chilenos que, desde mediados de 1812, se habían distanciado tanto del «fidelismo» limeño liderado por el propio Virrey como de las corporaciones españolas que gobernaban el imperio en nombre del rey cautivo.
¿Por qué leer a Husserl hoy?
Authors: Rizo-Patrón de Lerner Rosemary
Published: March 2023

Confieso, de entrada, que me intimida sobremanera verme hoy en la situación de tener que atender a esta gentil invitación de un grupo de estudiantes, en el marco de una serie de conferencias similares, respondiendo a una pregunta en apariencia simple e inocente: ¿por qué leer a Edmund Husserl, al iniciador del movimiento fenomenológico, precisamente hoy? Más aún si, en un cierto sentido, no puedo dejar de sentirme en una suerte de competencia -como en un torneo- en la que distintos atletas pugnan por romper marcas, o por lo menos conseguir la de bronce. ¿Se trata de convencerlos a leer?, ¿invitarlos y motivarlos a perder el miedo, a vencer su resistencia?, ¿animarlos acaso a la posibilidad de verse tocados, remecidos, por esta suerte de filósofo anacrónico -o quizá provocadoramente renovador- que, a través de un método inédito, y a contracorriente de una imperante, aunque soterrada, tradición neo-kantiana, quiere sentar las bases de un monstruoso proyecto filosófico de aparente corte «clásico»? Porque me temo que, con Husserl, el asunto se me presenta difícil. Máxime si mi presentación se ve rodeada de aquellas de mis colegas, que han expuesto y siguen exponiendo a extraordinarios filósofos, poetas, escritores, cuyas obras sí invitan a inspiradas travesías, intelectual y literariamente estimulantes. Por el contrario, ni a primera vista, ni luego de lidiar algún tiempo con alguno de sus textos, la obra de Edmund Husserl parece -a ojos generales- particularmente amable o atractiva.
¿Por qué leer a Davidson hoy?
Authors: Quintanilla Pérez Wicht Pablo
Published: March 2023

Si tuviera que contestar de una manera rápida y concisa a la pregunta por qué puede hoy resultar interesante leer a Donald Davidson, mi respuesta sería que él es uno de los filósofos post-analíticos más importantes del siglo XX, cuyo interés radica, entre otras cosas, en que es el autor que ha desplegado de manera más original y rica las principales intuiciones de los pragmatistas clásicos y del segundo Wittgenstein, yendo mucho más lejos que ellos. No creo que Davidson sea, en sentido estricto, un pragmatista ni tampoco un wittgensteiniano, pero pienso que él ha desarrollado creativamente ciertas tesis de esos autores de una manera que las transforma completamente, aplicándolas al esclarecimiento de nuevos problemas.
Corporate sustainability and shareholder return: A comparative study on the return of the shares that make up the B3 corporate sustainability index
Authors: Godinho Serra Alessandra , Tavares Rosana , Vieira Nunes Rodolfo , Ames Alice Carolina
Published: March 2023

This article aims to answer the following question: Do companies with sustainable initiatives bring a greater return to shareholders? The authors have built a hypothetical portfolio based on the B3 Corporate Sustainability Index (ISE) methodology through an ex-post facto descriptive research. The authors have also calculated the beta and weighted returns considering each share weight and the proportional impact on the portfolio. The alpha calculation and the association with the Student 's t-test allowed investigation on the possibility of an incremental return concerning the adopted reference. We have concluded that the responsible investment strategy in companies considered sustainable, through the hypothetical portfolio, does not bring the possibility of an incremental return to the shareholder when compared to the market portfolio. On the other hand, the hypothetical portfolio does not bring a return lower than the market portfolio. That is, its performance does not fall short.
Government incentives facing COVID-19: A comparative study between Brazil and Chile in light of communication theory
Authors: Oliveira Araújo Jamille Carla , Gentil de Souza Fernando , Da Silva Gomes Agostinha Patrícia
Published: March 2023

The COVID-19 pandemic forced different countries to implement new strategies to reduce its spread and mitigate its economic and social effects. Given this scenario, this study aims to compare government incentives granted by Brazil and Chile, in response to the economic effects of COVID-19. This qualitative and exploratory research uses indirect (bibliographic) and secondary documentation with data collected from the websites of the state governments in each country, between 2020 and 2021. The Iramuteq 2.0 software for data analysis. Based on Factorial Correspondence Analysis using a dendrogram, the study analyzes the incentives launched by: laws, decrees, contingency policies, guidelines in booklets, applications, and combating fake news, classified into 4 (four) categories: (i) tax and labor, (ii) actions on social networks, (iii) benefits programs and (iv) legalization. The results show that Chile offered more incentives than Brazil, highlighting the helping program from large companies to small ones, On the other hand, Brazil conducted more campaigns to combat fake news. In the light of the communication theory (CT), the findings highlighted the advances of governments in the expansion of digital channels (social networks, web pages and applications) to inform citizens and companies. During this period State Governments learned new insights to outline new strategies to stimulate the economy, to promote learning and increase the capacity to lead in contexts of crises and pandemic
Bird Electrocution on Power Lines in the Republic of Kalmykia (Russia) in 2021
Authors:   Chyornye Zemli State Biosphere Nature Reserve, Abushin A.A. , Erdnenov G.I. ,   Chyornye Zemli State Biosphere Nature Reserve
Published: March 2023

The article presents the results of the study of bird electrocution on power lines in the eastern part of the Republic of Kalmykia in 2021. 43 sections of 6–10 kV power lines with the total length of 472.4 km were examined. The remains of 106 birds that died due to electrocution and 5 birds that collided with wires were found upon our examination of 407.7 km of power lines dangerous to birds. The average density was 3.4±2.8 remains per 10 km of lines, with several mass mortality sections of up to 10.9 remains per 10 km identified. Birds of prey predominated among found remains (93%): the Steppe Eagle (Aquila nipalensis) – 26%, the Black Kite (Milvus migrans) – 25%, the Common Kestrel (Falco tinnunculus) – 13%, and other species. On the basis of our examination the damage caused by bird`s deaths while operating 6-10 kV power lines by Kalmenergo, a branch of Rosseti-Yug PJSC, amounted to 9,287,400 rubles. Based on the results of a claim by the RK Prosecutor's Office, the Elista City Court ordered Kalmenergo to equip all power lines in Sarpinsky and Harbinsky wildlife sanctuaries with bird protection devices.
Artificial Nests for the Saker Falcon in Mountainous Steppes of Southern Siberia – Platforms or Nestboxes?
Authors:   Sibecocenter LLC, Karyakin I.V. , Nikolenko E.G. ,   Sibecocenter LLC, Shnayder E.P. ,   Sibecocenter LLC, Shiriaev O.V. ,   Sibecocenter LLC
Published: March 2023

Installing artificial nests is a widely used method of managing wild bird populations around the world that allows to increase their numbers and/or productivity and breeding success. Among raptors this method is mostly used for small falcons and owls; however, artificial nests are also repeatedly used to attract such a rare species as the Saker Falcon (Falco cherrug) for breeding. We deployed a system of artificial nesting to restore the Saker Falcon population in former agrocenoses of Siberian mountain steppe and forest-steppe, which had not been used for agriculture since the collapse of the Soviet Union in 1991. Since 2006 our experiment showed a systematic increase in the Saker Falcon numbers from 1 to 47 pairs. Before 2018 we only used open platforms, and after 2018 we began to install nestboxes, so in the article we can compare birds' response to open and closed nests. We evaluate the artificial nesting impact on Saker Falcon population growth, as well as a number of other raptor species. We also describe the phenomenon of a sharp increase in the number of all raptor species in 2020–2021, attributing this to the impact of the COVID-19 pandemic.
Egyptian Vulture in the Karatau Mountains and Adjacent Territories, Kazakhstan
Authors:   Sibecocenter LLC, Karyakin I.V. , Knizhov K.I. ,   Sibecocenter LLC, Nikolenko E.G. ,   Sibecocenter LLC, Shiriaev O.V. ,   Sibecocenter LLC, Pulikova G.I. ,   Biodiversity Research and Conservation Center Community Trust, Kaptyonkina A.G. ,   Institute of Zoology of the Republic of Kazakhstan
Published: March 2023

Egyptian Vulture (Neophron percnopterus) is a globally threatened species. The northernmost limit of its breeding range is located in Kazakhstan and is fragmented into three large enclaves. The Karatau range is one such enclave. It was previously assumed that a small number of Egyptian Vultures nested here; however, research showed the fallacy of such ideas in 2010. In 2022, Karatau was surveyed in more detail to detect Egyptian Vultures. Based on the results of studies in 2010 and 2022, we modeled Egyptian Vulture distribution in Google Earth Engine using the image classification method — Random Forest (probability + regression) and calculated its possible abundance in Karatau utilizing several methods, including Distance Sampling. The area of Egyptian Vulture breeding biotopes is calculated to be 10,378.85 km2, habitat area – 34,576.8 km2. The Egyptian Vulture population in Karatau for 2022 is estimated at 171–298 breeding pairs (average of 278 breeding pairs), and 43–74 successful pairs (average of 69 successful pairs) (91 breeding territories are known). Based on obtained data and publications analysis, we assume that the Karatau Egyptian Vulture population is stable despite deterioration in habitat quality and reduction in breeding success of the species in recent years.
Expresión de predicados secundarios
Authors: Baranger Estefanía
Published: March 2023

El objetivo del presente trabajo es describir en términos sintácticos y semánticos los predicados secundarios [V2-reve] en mbya. Según los datos recolectados en terreno, la posposición reve, que generalmente es empleada en las lenguas de la familia tupi-guaraní para expresar relaciones de compañía y asociación, ha extendido sus contextos de uso en mbya como marcador de predicaciones secundarias depictivas cuando se adjunta a una base verbal. Escasos son los antecedentes en el estudio de la predicación secundaria y de esta construcción en las lenguas de la familia (cfr. Dooley 2013; Dietrich 2009). La propuesta del presente trabajo es analizar los [V2-reve] en mbya como una construcción depictiva (Schultze-Berndt y Himmelmann 2004; Himmelmann y Schultze-Berndt 2005) con base en que estas formas reducidas no pueden ser el único predicado de una oración y expresan un estado de cosas que tiene lugar durante la referencia temporal del evento expresado por el predicado principal, codificando predominantemente significados orientados a un participante del evento.
Arte oficial do segundo império?
Authors: Gomes Júnior Guilherme Simões
Published: March 2023

A tomar como mote a tese de Boime que identifica o Realismo como arte oficial do Segundo Império, o artigo reconstitui por sua própria conta os debates da época e examina na crítica e na pintura Chesneau e Meissonier, que também reivindicam o realismo, em contraposição aos heterodoxos capitaneados por Champfleury e Courbet. O exame da figuração artística e a crítica à tese de Boime são feitos a partir de três dimensões: o confronto entre autonomia e engajamento; o mercado e as fortunas artísticas; o individualismo do artista e o problema da anomia.
Literaturizando a Educação Alimentar e Nutricional
Authors: Oliveira Teresa Cristina Ciavaglia Vilardi , Nieto Carolina Yolanda Cerqueira Lima , Guimarães Cynthia Praia , Nunes Thais Gonçalves Alvites , Serra Giane Moliari Amaral , Souza Thais Salema Nogueira de
Published: March 2023

A efetivação de práticas de Educação Alimentar e Nutricional (EAN), no contexto da Segurança Alimentar e Nutricional (SAN), pressupõe ultrapassar os limites dos saberes específicos do nutricionista. Assim, este artigo apresenta um relato de experiência e tem por objetivo apresentar aspectos teórico-metodológicos e resultados de um Projeto de Iniciação Científica com estudantes de Nutrição com vistas a práxis da EAN na perspectiva da SAN, por meio da produção de texto e contação de história voltados ao público infanto juvenil. Os procedimentos metodológicos envolveram etapas de pesquisa bibliográfica; elaboração textual da história; avaliação por profissionais com formação e atuação nos campos de educação, alimentação e saúde; gravação da contação da história e divulgação em rede social. Dentre os resultados obtidos, destacam-se: a elaboração da versão final da história, “As aventuras de Dito em busca da comida de verdade”, após a avaliação dos especialistas, que versa sobre as afirmações do Manifesto Comida de Verdade alinhadas aos Objetivos de Desenvolvimento Sustentável (ODS); a criação do perfil @literaturizeando na rede social Instagram para socialização da contação da história; as contribuições para a formação das estudantes de nutrição, que participaram de rodas de conversa, típicas da práxis freireana, e desenvolveram habilidades e competências em uma importante área de atuação profissional do nutricionista, a Saúde Coletiva. Dessa forma, conclui-se que trazer à tona o debate sobre o DHAA, por meio de ações de EAN, envolvendo a escrita e a contação de histórias, é uma importante estratégia para o fortalecimento da educação e cultura em direitos humanos.
O Letramento matemático na BNCC
Authors: Paruta Anie Masquete , Cardoso Virgínia Cardia
Published: March 2023

Este estudo busca analisar como o Letramento Matemático é abordado na Base Nacional Comum Curricular (BNCC) dos Anos Iniciais do Ensino Fundamental. A partir da análise textual discursiva, procuramos compreender o conceito de letramento matemático que envolve além da consideração das práticas sociais no ensino, a busca por favorecer um olhar crítico frente às questões sociais. Assim, a relevância deste estudo decorre de considerar o letramento matemático como perspectiva, que busca considerar no ensino da matemática o contexto social e a formação de cidadãos que possuem autonomia para compreender e atuar na realidade. Como se trata de uma indicação normativa, se faz necessário um olhar atento, de modo que a BNCC não seja sinal de retrocesso no trabalho com a matemática. A partir deste estudo, foi possível perceber que a BNCC considera o letramento matemático no texto de apresentação da área, porém, há pouca evidência desta perspectiva nas habilidades indicadas.
DEVELOPING A KAUPAPA WHĀNAU FRAMEWORK TO EXPLORE SOCIAL, CULTURAL AND HEALTH BENEFITS OF A WHĀNAU-INSPIRED INITIATIVE
Authors:   Massey University, Reweti Angelique
Published: March 2023

Placing whānau at the centre of research design and delivery empowers whānau to take ownership of their own narrative while leveraging and extending their existing resources and knowledge systems. This article outlines the development of a kaupapa whānau research framework developed by whānau involved in a whānau-inspired initiative at their marae. Conducted in accordance with whānau principles, the research was guided by a tikanga approach to ensure that the experience was mana enhancing for all engaged. The conceptualisation of the kaupapa whānau framework reflects kōwhaiwhai from within the wharenui o tūpuna Parewahawaha and introduces concepts of whakapapa, wairua, kia whakatōmuri te haere whakamua, wānanga, and mana ake as guiding principles for conducting research alongside whānau. The framework emphasises the importance of being able to work alongside one’s own whānau by creating and using a research framework built around whānau worldviews and what they value.
Improving Sugarcane Bagasse as Animal Feed by Ammoniation and Followed by Fermentation with Trichoderma harzianum (In Vitro Study)
Authors: Samadi Samadi , Wajizah Siti , Usman Yunasri , Riayatsyah Denny , Firdausyi Zidny Al
Published: March 2023

Sugarcane bagasse is one of agro-industrial residues containing low nutrient content and difficult to be digested by animals.  However, it can be recycled to produce value-added product such as protein-enriched animal feed by application feed technology such as ammoniation and fermentation. The purposes of these experiments were to evaluate the quality and in vitro digestibility of sugarcane bagasse by using two steps feed technology process: ammoniation and continued by fermentation process. Two studies were conducted in these experiments.  The first study was to determine the quality of amoniated sugarcane bagasse after incubation at room temperature at different days (0, 7, 14, 21, 28 days) and the second study was to determine in vitro degestibility of  ammoniated sugarcane bagasse fermented by using the various levels of sago flour (0%, 5%, 10% and 15% from sample total) and kept at room temperature for 21 day in an-aerobic condition. Parameters measured in this study were DM, CP, CF, pH, OM, IVDMD (in vitro dry matter digestibility), IVOMD (in vitro organic matter digestibility). The model used for the statistical analysis was completely randomized design (CRD). The results of the first study indicated that length of incubation was not significantly affect (P>0.05) on crude fiber content but had significant effect (P<0.05) on crude protein content but only for control treatment. For the second study concluded that administration of the various levels of sago flour into ammoniated sugarcane bagasse fermented with T.harzianum significantly influenced (P<0.05) on OM, IVDMD and IVOMD but had not significantly effect on pH value. The results of the study indicated that application 10% of soluble carbohydrate from sago flour was recommended for fermentation process based on the results of in vitro and fermented feed quality studies.
Farmer Children’s Willingness for Dairy Farming succession in Banyumas Regency
Authors: Muatip Krismiwati , Sugiarto Moch
Published: March 2023

The objectives of this research were to 1) observe the age, education, farm parents’ cattle ownership, parents’ income, children’s perception and willingness for farming succession, and 2) investigate the relationship between age, education, farm parents’ cattle ownership, parents’ income, children’s perception of and willingness for farming succession. Purposive sampling was used to determine the regional sample in three districts in Banyumas regency with the most dairy cow population and were the supervised area subject to “Pesat” Milk Cooperative. Ninety respondents from 10-30 years old were determined. Result showed that farmers’ children had better education than the parents with average age of 21,67 years old. Average cattle ownership was 1-15 heads per household with Rp 564.167 – Rp 4.523.333monthly income. Farmers’ children shaped positive perception on dairy farming and had willingness for farming succession. Age was positively correlated with farming perception and willingness of the farmers’ children, while education was negatively correlated.
Evaluation of Performance in Female Madura Cattle in Madura Island, Indonesia
Authors: Nurgiartiningsih Veronica Margareta Ani , Budiarto Agus , Kusmartono Kusmartono , Suyadi Suyadi
Published: March 2023

This research was conducted to evaluate the performance of female Madura cattle in three districts of Madura Island (Sampang, Pamekasan, and Sumenep), known as breeding areas for purebred Madura cattle. Vital statistics of 1,040 female Madura cattle at 24 and 30 months old in Sampang, Pamekasan, and Sumenep district were measured and analysed. Mean of Body weight, chest girth, body length, and wither height of female Madura cattle at 24 months old were 191.7±17.6 kg, 133±3.0 cm, 124.0±2.1 cm, 115.7±2.9 cm, respectively, and those at 30 months old were 209.4±23.6 kg, 138.2±4.5 cm, 125.7±2.6 cm, 116.7±3.4 cm, respectively. The body weight, chest girth, body length of female Madura cattle at 24 and 30 months old in Pamekasan district (216.6±26.5 kg, 135.2±6.1 cm, 125.4±3.9 cm, and 238.0±28.5 kg, 141.5±6.7 cm, 127.9±3.5 cm, respectively) showed the highest value compared to those in Sampang and Sumenep district. Phenotypic correlation between vital statistics and body weight at 24 and 30 months old ranged between -0.43 to 0.90. Chest girth showed the positive highest correlation with body weight of female Madura cattle at 24 months old (0.24) and at 30 month old (0.90). It indicated that chest girth could be used as estimation parameter for body weight in female Madura cattle.
Amino Acid and Mineral Supplementation in Fermentation Process of Concentrate Protein of Jatropha Seed Cake (Jatropha curcas L.)
Authors: Widiyastuti Titin , Sutardi Tri Rahardjo
Published: March 2023

The purpose of this study is to assess the optimization of fermentation process by adding a minerals and amino acids so that the potential of protein  of Concentrate Protein-Jatropha seed cake (CP-JSC) can be optimally used as a substitute for soybean meal. The method used was completely randomized design. The treatment consisted of F1: Fermentation CP-BBJ + methionine-lysine (0.25%: 0.25%), F2: Fermentation CP-JSC + methionine-lysine (0.5%: 0.5%), F3: F1 + 0.45% Dicalsium Phosphate, F4: F2 + 0.45% Dicalsium Phosphate. Each treatment was repeated four times, When treatment significantly continued by Least Significant Difference (LSD), variables observed are the levels of antinutrients (phorbolester, antitrypsin), the levels of nutrients (fat, protein, crude fiber, Ca, P and gross energy) and amino acid. Results of analysis of variance showed that the addition of amino acids and minerals Ca, P in the fermentation process was highly significant effect on the levels of crude fiber and phosphorus (P <0.01) and significantly affected the gross energy content of CP-JSC post-fermentation (P <0.05). Dry matter, crude protein, crude lipid and calcium  are not affected by supplementation of methionine and lysine as well as calcium and phosphorus. Supplementation of methionine and lysine in the fermentation substrate showed good levels of essential amino acids and non essential higher than previous studies although not statistically significant (P> 0.05). While the levels obtained phorbolester range of 0.055% - 0.08%. It was concluded that the optimization of fermentation can be done without adding the amino acid supplementation of minerals calcium and phosphorus. Supplementation significantly affect a significant increase or decrease in some nutrients (crude fiber, gross energy, phosphor) and capable of suppressing a decrease in amino acids. Supplementation of amino acids Lysine and Methionin 0.05% is the best treatment.
Artificial intelligence-based comprehensive analysis of immune-stemness-tumor budding profile to predict survival of patients with pancreatic adenocarcinoma
Authors: Zhou Tianxing , Man Quan , Li Xueyang , Xie Yongjie , Hou Xupeng , Wang Hailong , Yan Jingrui , Wei Xueqing , Bai Weiwei , Liu Ziyun , Liu Jing , Hao Jihui
Published: March 2023

Objective: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy. CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB) have been significantly correlated with the outcome of patients with PDAC, but the correlations have been independently reported. In addition, no integrated immune-CSC-TB profile for predicting survival in patients with PDAC has been established. Methods: Multiplexed immunofluorescence and artificial intelligence (AI)-based comprehensive analyses were used for quantification and spatial distribution analysis of CD8+ T cells, CD133+ CSCs, and TB. In vivo humanized patient-derived xenograft (PDX) models were established. Nomogram analysis, calibration curve, time-dependent receiver operating characteristic curve, and decision curve analyses were performed using R software. Results: The established ‘anti-/pro-tumor’ models showed that the CD8+ T cell/TB, CD8+ T cell/CD133+ CSC, TB-adjacent CD8+ T cell, and CD133+ CSC-adjacent CD8+ T cell indices were positively associated with survival of patients with PDAC. These findings were validated using PDX-transplanted humanized mouse models. An integrated nomogram-based immune-CSC-TB profile that included the CD8+ T cell/TB and CD8+ T cell/CD133+ CSC indices was established and shown to be superior to the tumor-node-metastasis stage model in predicting survival of patients with PDAC. Conclusions: ‘Anti-/pro-tumor’ models and the spatial relationship among CD8+ T cells, CSCs, and TB within the tumor microenvironment were investigated. Novel strategies to predict the prognosis of patients with PDAC were established using AI-based comprehensive analysis and machine learning workflow. The nomogram-based immune-CSC-TB profile can provide accurate prognosis prediction for patients with PDAC.
MPI+OpenMP implementation of the conjugate gradient method with a factorized preconditioner based on the use of grid node reordering
Authors: Milyukova Olga Yurievna
Published: March 2023

The paper proposes ways to use MPI and MPI+OpenMP technologies for constructing and inverting a factorized preconditioner of the type incomplete triangular decomposition for solving systems of linear algebraic equations with an arbitrary symmetric positive definite matrix. Methods of using MPI and MPI+OpenMP technologies are based on the use of grid node orderings consistent with the division of the calculation area. The use of OpenMP technology in the construction and inversion of the preconditioner is carried out for most rows of the matrix. Comparative timing results for the MPI+OpenMP and MPI implementations of the proposed preconditioning used with the conjugate gradient method for a model problems and the sparse matrix collections SuiteSparse are presented.
Economic analysis and investment in fuel industry considering risk management by analytical hierarchy process
Authors:   University of Lampung, Zainal Anna Gustina , Djimad Habibullah ,   University of Lampung, Rudy  ,   University of Lampung, Suciska Wulan ,   University of Lampung, Djausal Gita Paramita ,   University of Lampung
Published: March 2023

Natural Gas production and distribution network plans are one of the most common ways to increase energy consumption efficiency. Due to the uncertainty of the economic parameters, the economic justification of this system is very difficult. In this research, the economic risk of investing in urban gas distribution systems has been done with the analytical hierarchy process (AHP). With the development and condensation of urban gas supply networks, accidents caused by gas leaks and other external factors have also increased. Therefore, in recent years, the issue of safety and risk analysis of urban gas networks has received special attention from responsible companies and other urban and safety experts. Gas distribution lines often pass in the vicinity of crowded areas and buildings, so any accident for these lines will lead to a lot of human and financial losses. In the present study, in order to improve the gas supply situation and reduce the risk of failure in Indonesia, urban gas pipelines have been studied to reduce the costs. In this paper, multi-criteria decision making method analysis is used to identify and evaluate the hazards of urban gas pipelines and the risk of occurrence of each hazard is calculated. There was a meaningful relationship based on economic-financial theories between economic factors and investment risk in the gas industry, which emphasizes the greater and more significant effect of exchange rate, failures and inflation rate variables in comparison with other research variables in the matter of controlling investment risk in the gas industry. The effects of changes in energy prices and the economic environment in explaining the behavior of investment risk in this industry have placed the next level of importance. The results showed that with the increase in energy prices, the economics of gas production and distribution risk management plans have improved and the regular trend of energy price increases can guarantee the profitability of fuel consumption optimization plans.
A socio-economic analysis of the role of medical drones in the era of the COVID-19 pandemic
Authors:   Airlangga University Hospital, Hidayat Niko Azhari , Sebayang Abed Nego Okthara ,   HKBP Nommensen University, Jumintono  ,   University Tun Hussein Onn Malaysia
Published: March 2023

Coronavirus is a large family of viruses that cause illness ranging from mild to severe symptoms. The high and fast transmission rate causes all activities in various fields, including the health and economic sector, to be carried out with caution. Different technologies are also developed to support health workers’ performance and financial circumstances, including drones in multiple aspects of medical needs ranging from delivering drugs and medical devices to carrying out vital sign checks. This study uses a qualitative descriptive. Data was obtained utilizing observation and literature study. Medical drones have a strategic role in fighting the COVID-19 pandemic, starting from the enforcement of social distancing programs, COVID-19 transport specimens to disinfection facilities in large areas. Medical drones are the latest technology in the medical field that helps medical performance improve healthcare service quality. The use of drones in the health sector needs to be further developed.
Team Approach: Use of Opioids in Orthopaedic Practice
Authors: Pasqualini Ignacio , Rullán Pedro J. , Deren Matthew , Krebs Viktor E. , Molloy Robert M. , Nystrom Lukas M. , Piuzzi Nicolas S.
Published: March 2023

» The opioid epidemic represents a serious health burden on patients across the United States.

» This epidemic is particularly pertinent to the field of orthopaedics because it is one of the fields providing the highest volume of opioid prescriptions.

» The use of opioids before orthopaedic surgery has been associated with decreased patient-reported outcomes, increased surgery-related complications, and chronic opioid use.

» Several patient-level factors, such as preoperative opioid consumption and musculoskeletal and mental health conditions, contribute to the prolonged use of opioids after surgery, and various screening tools for identifying high-risk drug use patterns are available.

» The identification of these high-risk patients should be followed by strategies aimed at mitigating opioid misuse, including patient education, opioid use optimization, and a collaborative approach between health care providers.
Further Insights into Deep Structure of Malmyzh, Pony-Muli, and Anadzhakan Ore Clusters in the Middle Amur Sedimentary Basin (Northern Sikhote-Alin Orogenic Belt)
Authors: Didenko A.N. , Nosyrev M.Yu. , Gil’manova G.Z.
Published: March 2023

—Magnetic and density depth models were calculated for the Malmyzh, Pony-Muli, and Anadzhakan porphyry-copper ore clusters emplaced in the northern part of the Middle Amur sedimentary basin. Based on analysis of anomalous magnetic field (magnetic model) data, a magmatogenic ring structure determining spatial patterns in localization of porphyry-copper mineralization in the Malmyzh and Pony-Muli ore clusters was established. It is shown that similar structures in the anomalous magnetic field are reported for many porphyry copper deposits. The area of the identified geologic structure can be considered as a high-potential region for detection of goldcopper-porphyry ore mineralization. Within the ring structure, perspective areas containing granitoid and diorite intrusions developed along its periphery and seated beneath the Middle Amur basin sedimentary cover can also be identified. Geophysical depth models are calculated for individual ore clusters with Au–Cu porphyry mineralization, to determine subsurface lithology and structures that may be useful for assessing regional ore potential and deducing areas for metallogenic exploration. The geophysical data-based deep subsurface model for the Malmyzh ore cluster is found to be consistent with the integrated petrological models developed by Richards and Sillitoe for giant Cuporphyry deposits.
Chemically defined cytokine-free expansion of human haematopoietic stem cells
Authors: Sakurai Masatoshi , Ishitsuka Kantaro , Yamazaki Satoshi
Published: March 2023

The ex vivo expansion of human hematopoietic stem/progenitor cells (HSPCs) has important applications in both basic research and clinical transplantation therapy. Here, we introduce the protocol of a novel culture system that supports the long-term ex vivo expansion of human HSPCs, achieved through the complete replacement of cytokines and albumin by chemical agonists and a caprolactam-based polymer. A phosphoinositide 3-kinase activator in combination with a thrombopoietin receptor agonist and the pyrimidoindole derivative UM171 were sufficient to stimulate functional expansion of umbilical cord blood-derived HSCs. We envision that this chemically defined expansion culture system will help to advance clinical HSC therapies.
Reflections on the Implementation of Wearable Vital Signs Monitors in a Vietnamese ICU
Authors: McKnight Jacob , Luu An Phuoc , Nuil Jennifer Van , Phan Khanh Nguyen Quoc , Hoang Van Minh Tu , Phung Nhat Tran Huy , Nguyen Tung Le Nhu , Nguyen Hao Van , Dao Khoa Bach , Ho Hai Bich , Le Khanh Thuy Thuy , Nguyen Huy Quang , Lam Yen Minh , Truong Trung Ngoc , Nguyen Truong Thanh , Nguyen Chau Van Vinh , Thwaites Louise
Published: March 2023

The number of patients in need of critical care increased sharply in Vietnam during the COVID-19 pandemic putting increased pressure on the Hospital for Tropical Diseases, which was designated as a centre for treatment. In order to meet the new demand for critical care, the hospital introduced a prototype wearable system to monitor the vital signs of COVID patients. We describe how the introduction of the wearables was supported by a group of implementation scientists using an action learning approach. The support of a dedicated implementation team facilitated the implementation process and enabled significant advances in a limited time. We found that while the devices addressed a significant demand for remote monitoring, they also created new types of work. The burden of this work was not shared equally and significant thought was needed to find ways of optimising the use of the system, leading to altered workflows and staff training. We conclude that with the right support and planning however, well designed wearables offer promising opportunities for managing critically ill patients.
An approach to the micro-strain distribution inside nanoparticle structure
Authors: Abdel-Rahman Ahmed Sabry
Published: March 2023

The importance of nanotechnology is increasing day by day, and to allow the nanoparticles to do what we hope, explicit modelling of nanostructures is necessary. Considering the strain inside the nanoparticle is the major subject that changes the point of view to the unique properties of the material on the nanoscale. Williamson-Hall, Stocks-Wilson, Debye-Scherrer, Halder-Wagner, and Size-Strain Plot (SSP) methods are used essentially to insure the material particle size falls at the nano-level, they treat the broadening in the XRD peak as a sum of Gauss and Lorentz diffraction probability functions. In this work, when modelling a nanostructure as a liquid drop where surface tension controls the particle position and strain controls the geometry and spacing of the lattice parameters, the number of the diffraction planes is used instead of the line intensity and shows a Gaussian-like (or Lorentzian-like) function that is investigated with numerical analysis. The model writes an equation about the broadening, peak position, and lattice parameters to estimate the crystalline size and strain exponent. Williamson-Hall, Stocks-Wilson, and Debye-Scherrer can be explained as approximations for this model, and once the negative strain is explained, possible approximations can show Halder-Wagner and SSP another face of the strain distribution model equation.
“…, I don’t think the disease is real, some people have just taken pictures to scare us to take the medications”: A qualitative study exploring perceptions about mass drug administration acceptance for lymphatic filariasis in Ghanaian communities
Authors: Muroka Trusila A , Glozah Franklin N
Published: March 2023

Background
Mass drug administration (MDA) is a means of delivering safe and affordable essential evidence-based interventions based on the principles of preventive chemotherapy, where various populations or sub-population groups are offered treatment without individual diagnosis. Several communities have been provided with MDA (i.e., Ivermectin and Albendazole) with the aim of eliminating Lymphatic Filariasis (LF) from Ghana. Notwithstanding the administration of 13 rounds of MDA from 2005 to 2019, the prevalence of LF as at 2020 in some communities is still high. The aim of this study is to explored perceptions about MDA acceptance for LF in Ghanaian communities.
Methods
A qualitative research design using a descriptive phenomenology and narrative inquiry was used in the study to either purposively or randomly select community members, patients, and community drug distributors in 12 communities in the Bono region of Ghana. In-depth interviews and focus group discussions were used to collect data. Interviews were transcribed verbatim and analyzed using thematic analysis in NVivo 12 software.
Results
The results show that chronic clinical symptoms of LF influenced community members’ perception and acceptance of the MDA intervention. Also, community members perceived that the acceptability and uptake of the MDA intervention could be improved by including patients in the programme, carrying out continuous education, and engaging in social mobilization activities in the communities.
Conclusions
There is an urgent need to educate and engage communities with regard to the critical role MDA intervention can play to eliminate LF from Ghana.
Ecological Toxicity Alleviation of Imazethapyr to Non-target Plant Wheat: Active Regulation Between Auxin and DIMBOA
Authors: Huang Jinye , Li Jun , Chen Hui , Shen Chensi , Wen Yuezhong
Published: March 2023

A new perspective was put forward to alleviate the potential
toxicity of herbicide (R)-imazethapyr ((R)-IM) to
non-target plant wheat by active regulation between auxin and
secondary metabolite
2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazine-3(4H)-one
(DIMBOA) in this study. (R)-IM effortlessly disrupted the
balance between wheat growth and defense, which not only reduced
32.4% auxin content in wheat leaves, but also induced 40.7% DIMBOA
accumulation compared to the control group. Transcriptomic results
indicate that restoration of the auxin level in plants promotes the
up-regulation of growth-related genes and increased accumulation of
DIMBOA increases the expression of defense-related genes. Auxin and
DIMBOA are in two divergent paths and alleviate herbicide stress on
wheat primarily through effects on growth and defense,
respectively. Additionally, as a common precursor of both auxin and
DIMBOA, indole adopted a combined growth and defense strategy in
response to (R)-IM toxicity, i.e., both restoring growth
development and enhancing the defense system. It might be possible
to find appropriate ways to regulate the plant growth-defense
balance under herbicide stress by regulating auxin and DIMBOA
levels in plants. Our insight into the interference mechanism of
herbicides to the plant growth-defense system will facilitate the
design of improved strategies for herbicide detoxification.
TrkB phosphorylation in serum extracellular vesicles correlates with cognitive function enhanced by ergothioneine in humans
Authors: Kato Yukio , Ishimoto Takahiro , Yamashita Reiya , Matsumoto Ruri , Matsumoto Satoshi , Matsuo Yusuke , Nakao Shunsuke , Masuo Yusuke , Suzuki Makoto
Published: March 2023

Oral administration of the food-derived antioxidant amino acid ergothioneine (ERGO) results in its efficient distribution in the brain and enhanced cognitive function. However, the effect of ERGO deficiency on cognitive impairment and the underlying mechanisms remain unknown. We revealed that cognitive function and hippocampal neurogenesis were lower in mice fed an ERGO-free diet than in those fed the control diet. Furthermore, ERGO supplementation to achieve the control diet ERGO levels reversed these effects and restored ERGO concentrations in the plasma and hippocampus. The ERGO-induced recovery of cognitive function and hippocampal neurogenesis was blocked by TrkB inhibition, with a concomitant reduction in hippocampal phosphorylated TrkB, suggesting the involvement of TrkB activation in these events. Phosphorylated TrkB was also detected in extracellular vesicles (EVs) derived from serum samples of volunteers who had been orally administered ERGO-containing tablets (5 mg/day for 12 weeks). Importantly, the ratio of serum EV-derived phosphorylated TrkB was significantly higher in the ERGO-treated group than in the placebo-treated group and was positively correlated with both serum ERGO concentrations and several cognitive domain scores from Cognitrax. Altogether, TrkB phosphorylation is involved in ERGO-induced cognitive enhancement, and TrkB phosphorylation levels in serum EVs may quantitatively represent ERGO-induced cognitive enhancement in humans.
Role of the GalNAc-galectin pathway in the healing of premature rupture of membranes
Authors: Chen Jia-Le , Liu Lou , Peng Xin-Rui , Wang Yan , Xiang Xiang , Chen Yu , Xu De-xiang , Chen Daozhen
Published: March 2023

Background: Premature rupture of membranes is an important cause of preterm birth and its associated high infant mortality and morbidity, and is an important public health problem worldwide, but the mechanism is unknown, and clinical treatment is currently mainly conservative, with a lack of effective interventions. We compared the differential metabolites in vaginal secretions between patients with preterm premature rupture of membranes and those with normal pregnancies and screened for the protective substance N-acetyl-d-galactosamine (GalNAc), an important ligand for galectin, which has several biological activities such as anti-inflammatory, antioxidant and in vitro wound healing properties.
Methods: We evaluated the inflammatory response, oxidative stress, proliferation migration, EMT and ECM remodelling of human amniotic epithelial cells (WISH) by ELISA, ROS, transwell, scratch and CCK-8 assays, and examined the expression of PCNA and AKT by Western Blot.
Results: The results showed that GalNAc enhanced galectin production and inhibited cellular inflammation and oxidative stress, promoted cellular EMT and migration, and altered ECM composition. In addition, GalNAc reduced the total and phosphorylated protein levels of AKT enhancing the pro-cell migration ability of GalNAc to stimulate wound healing.
Conclusions: The results showed that GalNAc enhanced galectin production and inhibited cellular inflammation and oxidative stress, promoted cellular EMT and migration, synthesized GAG and altered ECM composition. The GalNAc-galectin pathway may provide a theoretical basis and a new target for the prevention and treatment of premature rupture of membranes.
This study provides a theoretical basis and a new target for the prevention and treatment of premature rupture of membranes.
Modeling of Hydrodynamic parameters of rotating disc contactors (RDCs) using response surface methodology: holdup and drop size
Authors: Mirzaei Shaparak , Ghaemi Ahad , Hemmati Alireza , Shirvani Mansour , Ardestani Fatemeh
Published: March 2023

In this study, the behavior of hydrodynamic parameters was investigated in agitated columns including Asymmetric rotating disc contactor (ARDC), Perforated rotating disc contactor (PRDC), Oldshue-Rushton column (ORC), and Kuhni for three different systems such as butanol-water, n-butyl acetate-water and toluene-water. The effects of various parameters including rotor speed (rpm), dispersed and continuous phase velocities, and interfacial parameters were studied on the dispersed phase holdup and Sauter mean drop diameter. The results showed that the enhancement of rotor speed, and dispersed and continuous phase velocities would enhance the dispersed phased holdup. Among these, PRDC shows the least enhancement of dispersed phase holdup compared to the other three columns. The investigation of Sauter mean drop diameter changes in the columns showed that the droplet size decreases sharply as the rotor speed increases, which this decrease of droplet size is greater in ORC and Kuhni columns than in the other two columns. The results also show that by increasing dispersed phase velocity in the four columns, the droplet size in ORC column is larger than the columns, However, by increasing continuous phase velocity, subtle changes in droplet size are observed, Based on the experimental data, new correlations have been presented to predict Sauter mean drop diameter and dispersed phase holdup for agitated columns by the analysis of the variance (ANOVA). The coefficient of determination (R2) was obtained 0.9612 and 0.9495 for Sauter mean drop diameter and dispersed phase holdup, respectively, indicating a good correlation between the predicted and observed and values of the models.
Importance of nuclear localization signal-fused Cas9 in the production of genome-edited mice via embryo electroporation
Authors: Niinuma Sakura , Wake Yui , Nakagawa Yuki , Kaneko Takehito
Published: March 2023

Previously, to generate genome-edited animals by introducing CRISPR-associated protein 9 (Cas9) into embryos, we developed the Technique for Animal Knockout system by Electroporation (TAKE). Additionally, by fluorescently labeling Cas9, we successfully visualized the Cas9 introduced into the pronuclei of embryos; however, whether Cas9 was introduced directly into the pronuclei by electric pulse or transferred from the cytoplasm by nuclear localization signal (NLS) remained unknown. Herein, we evaluated the localization of Cas9 with (Cas9-NLS) or without NLS (Cas9-noNLS) in mice embryos following electroporation by fusing them with GFP. Furthermore, we visually studied their effects on genome-editing rates in offspring by targeting tyrosinase gene. Fluorescence intensity in pronuclei of Cas9-NLS-electroporated embryos and genome-editing rates of offspring were significantly higher than those of Cas9-noNLS-electroporated embryos. Furthermore, fluorescence in Cas9-NLS-electroporated embryos in which pronuclei had not yet appeared 2.5 h after insemination was observed in the pronuclei of embryos appearing 3.5 h after electroporation. We demonstrated the effective transportation of Cas9 from the cytoplasm to pronuclei by the NLS following TAKE, which resulted in increased genome-editing rates in offspring. The TAKE along with fluorescently labeled nucleases can be used to verify nuclease delivery into individual embryos prior to embryo transfer for efficiently producing genome-edited animals.