bluuebunny/crossref_metadata_2025 huggingface dataset:
Small intestinal submucosa promotes angiogenesis via the Hippo pathway to improve vaginal repair
Authors: Xiao Yanlai , Tian Yanpeng , Zhang Jingkun , Li Qian , Shi Wenxin , Huang Xianghua
Published: May 2023

Vaginal reconstruction has incorporated the use of gastrointestinal segments for decades, but the technique is inevitably associated with complications. Tissue-engineering techniques, however, have brought great hope for vaginal reconstruction. This study aimed to evaluate the utility of small intestinal submucosa (SIS) in reconstructing clinically significant large vaginal defects in a porcine model and to investigate the role of the Hippo pathway in the vascular remodeling process. The composition and mechanical properties of SIS were characterized. Full-thickness vaginal defects were established in 10 minipig donors, with 4 cm lengths removed and replaced by an equal sized SIS scaffolds. The neovaginas were subjected to macroscopic, histological, immunohistochemical and molecular evaluations at 4 and 12 weeks after the surgery. Four weeks after the operation, extracellular matrix reorganization and complete coverage the surface of the luminal matrix by vaginal epithelium were observed, accompanied by the formation of a microvascular network and the regeneration of smooth muscles, albeit disorderly arranged. Twelve weeks after implantation, enhacements were seen in the formation of the multi-layered squamous epithelium, angiogenesis, and large muscle bundle formation in the vagina. Aditionally, the expression levels of angiogenesis-related proteins, proliferation-related proteins and Hippo pathway-related proteins in the neovagina were significantly increased. These results indicate that SIS could be used to reconstruct large vaginal defects and that the vascular remodeling process is potentially regulated by the Hippo pathway.
Extended combined screening for preeclampsia prediction in women with diabetes mellitus
Authors: Kapustin Roman V. , Tcybuk Elizaveta M. , Kopteeva Ekaterina V. , Alekseenkova Elena N. , Chepanov Sergey V. , Shelaeva Elizaveta V. , Arzhanova Olga N. , Korenevsky Andrey V. , Kogan Igor Yu.
Published: May 2023

BACKGROUND:Early screening for preeclampsia has shown high efficiency for low-risk groups, however, the presence of systemic vascular disease in patients with diabetes mellitus complicates their use and requires the development of additional approaches to predicting preeclampsia in this group of patients.
AIM:The aim of this study was to evaluate the effectiveness of early prediction of preeclampsia with extended combined screening in patients with pregestational types of diabetes mellitus.
MATERIALS AND METHODS:This study included 75 pregnant women: 40 patients with type 1 diabetes mellitus, and 35 patients with type 2 diabetes mellitus. To determine the risk of further preeclampsia development, we evaluated biochemical, biophysical and anamnestic factors, along with the serum levels of placental growth factor, soluble fms-like tyrosine kinase 1, and soluble endoglin at 11+0to 13+6gestational weeks. The main outcome assessed was the development of preeclampsia.
RESULTS:In patients with further development of preeclampsia (35% in type 1 and 40 % in type 2 diabetic women), we observed higher soluble fms-like tyrosine kinase 1 / placental growth factor ratios, as well as elevated serum soluble endoglin (type 1 diabetes mellitus) and soluble fms-like tyrosine kinase 1 (type 2 diabetes mellitus) levels. Isolated determination of placental growth factor showed no significant differences in the levels of this angiogenic factor in preeclampsia. A multivariate predictive model for preeclampsia demonstrated high prognostic parameters: for patients with type 1 diabetes mellitus, area under the curve was 0.96 (95% confidence interval 0.931.00), with positive predictive value 76.7% and negative predictive value 90.1%; for patients with type 2 diabetes mellitus, area under the curve was 0.94 (95% confidence interval 0.861.00), with positive predictive value 88.5% and negative predictive value 97.1%.
CONCLUSIONS:Specific biochemical and biophysical markers of preeclampsia combined with maternal risk factors and assessment of carbohydrate metabolism can increase the predictive value of early screening studies for preeclampsia in women with pregestational diabetes mellitus.
A history of low-dose ethanol alters behavioral strategy selection and ventral hippocampus function
Authors:   , Bryant Kathleen Grace Marion , Barker Jacqueline M
Published: May 2023

More than half of adults within the U.S. have consumed alcohol within the past year, but do not meet criteria for alcohol use disorder (AUD). Chronic alcohol use at sub-diagnostic, casual drinking levels is common and can produce profound neurobiological and behavioral changes that impact reward learning and seeking. These alterations may further engender subsequent vulnerability to AUD. The ventral hippocampus (vHPC) is increasingly considered a critical contributor to reward learning and seeking. Glutamatergic neurons and synapses are particularly sensitive to low doses of ethanol, and the vHPC contains a high number of glutamatergic neurons. Indeed, the vHPC is one of the first regions to exhibit changes in neuronal activity and pyramidal neuron loss as a result of chronic ethanol exposure. Thus, the broad objective of my thesis work was to identify long-term effects of low-dose ethanol on reward seeking and vHPC function. My behavioral findings showed that a history of repeated, low-dose ethanol exposure did not globally promote inflexible reward seeking. However, low-dose ethanol exposure increased motivated sucrose seeking - as measured by progressive ratio (PR) responding - in male, but not female, mice. I also found that low-dose ethanol exposure altered behavioral strategy selection, and this was associated with differences in motivated behavior depending on differences in reinforcement schedule history. To investigate whether a history of low-dose ethanol exposure altered vHPC activity during motivated behavior, mice were implanted with an electrode array in the vHPC. Neural activity was recorded during performance of the PR task and analyzed surrounding key behavioral events. My results demonstrated that vHPC activity was suppressed following reward seeking behavior (lever press) in ethanol-naïve mice, whereas this suppression preceded the lever press in ethanol-exposed mice. This was specific to reward seeking, as I found no ethanol-induced differences in activity surrounding reward checking behavior (magazine entry). To determine whether inhibition of vHPC activity was sufficient to alter motivated reward seeking, vHPC activity was inhibited during discrete temporal epochs time locked to mouse behavior using closed-loop optogenetics. Brief vHPC inhibition increased breakpoints on the PR test in ethanol-naive-, but not ethanol-exposed, mice. Further, inhibition of vHPC reduced latencies to check for reward delivery in ethanol-naive-, but not ethanol-exposed, mice. These results suggest that a history of low-dose ethanol exposure dysregulates vHPC activity during reward seeking and fundamentally changes the role of vHPC activity in modulating motivated behavior. A greater understanding of the neurobiological and behavioral substrates impacted by low-dose ethanol exposure can help identify factors placing casual drinkers at risk for transition to AUD.
Self-Compassion Based on Gender and Student Academic Achievement
Authors: Setiani Ismarini Bekti , Titi Dwitias
Published: May 2023

Abstract: This study aims to determine the effect of gender on the level of students’ self-compassion and determine the effect of students’ level of self-compassion on their academic achievement. This study uses a quantitative approach, with the type of ex-post facto research and ordinal regression analysis. The data were collected using the Self-Compassion Scale (SWD) with alternative answers from one to five of scale. The sample in this study was students at Universitas Negeri Yogyakarta. Our analysis results showed no significant effect of gender on the students’ level of self-compassion and no significant effect of students’ level of self-compassion on their academic achievement.
Abstrak: Penelitian bertujuan untuk mengetahui pengaruh gender terhadap tingkat welas diri mahasiswa, dan mengetahui pengaruh tingkat welas diri terhadap prestasi akademik mahasiswa. Penelitian ini menggunakan pendekatan kuantitatif, dengan jenis penelitian ex-post facto dan menggunakan analisis regresi ordinal. Instrumen pengumpul data menggunakan Skala Welas Diri (SWD) dengan alternatif jawaban dari skala satu sampai skala lima. Sampel dalam penelitian ini adalah mahasiswa di Universitas Negeri Yogyakarta. Hasil penelitian menunjukkan bahwa gender tidak memiliki pengaruh signifikan terhadap tingkat welas diri mahasiswa dan tidak terdapat pengaruh signifikan tingkat welas diri terhadap prestasi akademik mahasiswa.
DEMOKRASİ KONULU HABERLERİN YEREL BASINDAKİ YANSIMALARININ İNCELENMESİ (1946-1960 MALATYA ÖRNEĞİ)
Authors: Doğan İbrahim Halil , Aydın Mesut
Published: May 2023

Bir milletin günlükleri olarak ifade edebileceğimiz gazeteler; çıkarıldığı dönemin toplumsal ve siyasal dokusu, değerleri, kişilikleri ve kurumları hakkında bilgiler içermektedir. Gazeteler, yalnızca yayımlandığı dönemin haber kaynağı değil, sonraki yıllarda da siyasetten tarihe, ekonomiden eğitime, hukuktan sosyolojiye birçok bilim dalının kullanabileceği zengin bir veri kaynağı sunmaktadır. Araştırmada, 1946-1960 yılları arasındaki demokrasi konulu haberlerin Malatya yerel basınındaki yansımalarını incelemek amaçlanmıştır. Araştırma, nitel bir yönteme sahip olup durum çalışması modeli kullanılmıştır. Milli Kütüphane Süreli Yayınlar Arşivindeki 1946-1960 yılları arasında Malatya yerel basınında yer alan Fırat, Malatya Postası ve Yeni Malatya Postası gazeteleri araştırmanın çalışma grubu olarak belirlenmiştir. Belirlenen gazeteler içerisinden 7000’ne yakın gazete sayfası taranıp demokrasi haberleri esas alınmış ve ölçüt örnekleme yöntemi kullanılmıştır. Tarama sonucunda demokrasi konusuyla ilişkili toplam 891 habere ulaşılmış, sekiz kategoride tasnif edilerek kodlamalar yapılmıştır. Araştırmada veri toplama aracı olarak doküman incelemesi yöntemi kullanılmış, verilerin analizinde ise içerik analizi tekniği uygulanmıştır. Yapılan analizler doğrultusunda, 1946’da Türkiye’nin çok partili siyasal hayata geçişinden 1960’a kadarki süreçte demokrasi anlayışı, kültürü, kurumları, dönemin siyasi dokusu ve kişilikleri Malatya yerel basını örneği üzerinden yansıtılmaya çalışıldığı sonucuna ulaşılmıştır.
A clinical analysis of ectopic pregnancies in a tertiary care centre: A one year retrospective study
Authors: Battu Gangajamuna , Tatikunta Vijayakrishna , Rameshwaram Priyadarshini
Published: May 2023

Following fertilization and fallopian tube transit, the blastocyst normally implants in the endometrial lining of the uterine cavity. An ectopic pregnancy occurs when a fertilized ovum implants outside the normal uterine cavity. Fortunately, beta-human chorionic gonadotropin (β-hCG) assays and transvaginal sonography (TVS) aid earlier diagnosis, maternal survival, and fertility conservation. Ruptured ectopic is a surgical emergency.

To study and analyse ectopic pregnancies in a tertiary care centre.

To determine the incidence, risk factors, clinical presentation, management, morbidity and mortality of ectopic pregnancy.

: A retrospective analysis of ectopic pregnancies was done in Gandhi hospital, Secunderabad from October 2021 to September 2022 (1 year duration) with a sample of 97 cases of suspected ectopic pregnancies observed and treated, out of total 11252 pregnant women admitted.

The incidence of ectopic pregnancy was 8 per 1000(0.81%) pregnancies, majority between the age of 20-30yrs (87.5%) and in higher order pregnancies (3or>3 pregnancies) (50.4%). Risk factors were multiparity (50.5%), h/o infertility treatment (12.3%), tubal sterilisation (7.2%). The typical triad of amenorrhoea, pain abdomen and bleeding p/v was observed in 69% of cases. In 16.4% cases the haemoglobin was <7gm% at presentation. Among 97 suspected cases of ectopic pregnancies, 90(92.7%) cases were found to have ectopic pregnancy. 27.8% of cases were presented in class 2 or more haemorrhagic shock. 79% cases were ruptured ectopic pregnancies. Ampullary ectopic pregnancies were predominant(62.9%) followed by corneal (14.6%) > fimbrial(13.4%) > ovarian(4.4%)> isthmus (2.2%). 2 women among 97 cases of suspected ectopic pregnancies were found to have Heterotopic pregnancy {tubal+intrauterine [missed abortion]}. Unilateral salpingectomy was done in 90.5% cases. Medical management was done successfully with single dose of methotrexate in 1 case. Blood transfusions were given in 69.9% cases. Post op wound complications were observed in 3.1% cases. Mortality is zero in present study.

Clinicians should be aware of the fact that any women in reproductive age group presenting with pain in lower abdomen or vaginal bleeding, ectopic pregnancy should be suspected irrespective of presence or absence of amenorrhoea, whether or not she has undergone sterilization, because early diagnosis is critical in reducing maternal morbidity and mortality and improving treatment success rates.
Assessment of risk of malignancy index scoring and histopathological correlation in the diagnosis and management of adnexal mass
Authors: Uvajanani S S  , Maharajan S  , Indirani T V
Published: May 2023

: Pathologies of adnexal masses are commonly benign. The malignant lesions of adnexa carries a very low five-year survival rate, and hence the early recognition need to be done. There is no single gold standard investigation for the diagnosis of the malignancy of the adnexa. Risk of Malignancy Index (RMI) scoring system, combines the Serum CA 125(U/ML), Ultrasound score (U) and the menopausal status(M).

: To assess the efficiency of Risk of Malignancy Index-3 (RMI-3) scoring system in discriminating benign and malignant adnexal mass, for early detection and management of malignant ovarian mass.

: This is a prospective, observational study, among 50 female patients above the age of 25 years, diagnosed with adnexal mass under the Department of obstetrics and gynaecology, Government Rajaji Hospital, affiliated to Madurai Medical College, Madurai.

All the study participants were subjected to detailed history taking, thorough clinical examination, ultrasonogram of abdomen and pelvis, and markers such as CA 125. Risk of Malignancy Index was calculated and correlated with the histopathological (HPE) findings of the excised tumours.

: When the cut off of RMI score for predicting malignancy is 149.2 which had a sensitivity of 79.2%, specificity of 92.3%, positive predictive value of 90.47%, negative predictive value of 82.78% and a diagnostic accuracy of 86.01%.

: Risk of Malignancy Index score is a simple tool, with a good diagnostic accuracy, hence it can be used as good screening tool for identification of the malignant lesions from the adnexal mass.
Историографический аспект некоторых аспектов профессионализма и нравственного облика полиции: по материалам журнала «Вестник полиции» (1911 г.)
Authors: Чимаров С.Ю.
Published: May 2023

В статье представлен анализ отечественной историографии, обращенной к области полицеистики. Воспринимая публикации отдельных журналов в качестве ценного историографического источника, автор апеллирует к страницам журнала «Вестник полиции» за 1911 г. Несмотря на выбор автором одного года для проведения им анализа контента указанного печатного издания, предложенный метод подтверждает многогранность направленности статей журнала, а также важность их просветительского и воспитательного характера для чинов полиции.
Роль Ф. Ницше в формировании концепции философии жизни
Authors: Гизатулллина Н.Р. , Бадретдинова С.А.
Published: May 2023

В статье рассматривается вклад одного из самых значительных философов второй половины ХIХ века – Фридриха Ницше – в становление концепции философии жизни. Основной акцент авторы сделали на раскрытии понимания данным философом «философии жизни» и таких ее ключевых составляющих, как «интеллект философии жизни», культура, «сверхчеловек» и «воля к власти».
Философия Сфера Боспорского и ее значение для формирования мировоззренческой позиции современной генерации начальствующих лиц российской полиции
Authors: Чимаров С.Ю.
Published: May 2023

Статья посвящена анализу некоторых концептуальных воззрений философа-стоика античного периода Сфера Боспорского, имеющих важное значение для формирования новых представлений со стороны его последователей на область воспитания человека. Презентуя мастерство отмеченного философа в применении полемического и диалектического потенциала с целью воздействия на свою аудиторию, автор замечает актуальность постижения начальствующим лицом полиции образцов философии наших великих предшественников и умения грамотного применения их рекомендаций в практической работе с личным составом.
Социокультурный контекст дистанционного обучения ивриту
Authors: Ханчас В.Н.
Published: May 2023

В статье рассмотрен социокультурный контекст дистанционного обучения ивриту, основанного на диалоге культур. Реализация социокультурного потенциала языкового образования предполагает проектирование электронной информационно-образовательной среды, обеспечивающей эффективное взаимодействие между участниками образовательного процесса, а также сотрудничество с музеями, библиотеками, культурно-досуговыми организациями и центрами, обеспечивающее присвоение общечеловеческих и национальных ценностей. Автором охарактеризованы следующие формы для проведения онлайн занятий по изучению иврита, позволяющие реализовать социокультурный подход: видеолекция, «видеоконференция-демонстрация», интерактивный «круглый стол», позиционный семинар. Данные способы организации дистанционного обучения создают условия для эффективного взаимодействия субъектов учебного процесса. Социокультурный контекст в содержании онлайн занятий предполагает активное внедрение в учебный процесс лингвокраеведения, изучения диалектной лексики, лингнокомпаративного анализа.
Профилактика стрессовых заболеваний у студентов
Authors: Тейдер А.Г.
Published: May 2023

В статье рассматривается проблема профилактики эмоционального стресса, в частности экзаменационного, наблюдаемого в предсессионные периоды у студентов. Анализируются пути и способы минимизации разрушающего воздействия стресса через выработку антистрессовой стратегии поведения, приводятся рекомендации, техники профилактической направленности.
Роль политического конфликта в практике муниципального управления
Authors: Мищенко Я.П. , Фомичева К.С.
Published: May 2023

Научно-исследовательская работа посвящена рассмотрению вопроса конфликтов, возникающих среди должностных лиц на муниципальной службе. Автором предпринята попытка обозначения основных проблем и путей разрешения конфликтов в контексте муниципального управления в России. Обозначен понятийно-категориальный аппарат, в котором определены основные формы и виды актуальных конфликтов на муниципальной и муниципальной службе, проведен анализ природы и причин возникновения конфликтов.
Использование технологии дипфейк в ОВД
Authors: Смирнов В.М. , Сушенцев А.С.
Published: May 2023

В статье рассматривается использование в гражданских целях и в сфере ОВД технологии дипфейк
Исследование зависимости показателей анализа крови у пациентов с гипертонической болезнью
Authors: Старовойтова С.И. , Гладких В.В. , Капралов А.И. , Фертикова Н.С.
Published: May 2023

В статье рассматриваются показатели анализов сыворотки крови пациентов при гипертонической болезни, такие как глюкоза, холестерин, прямой билирубин, непрямой билирубин.
Восстановление N-(2,4-динитрофенил)пиперидина. Уточнение состава продуктов и протекающих химических реакций
Authors: Соколов А.А. , Бородина М.В. , Макарова Е.С.
Published: May 2023

В статье приведено углубленное изучение ранее описанного процесса восстановления N-(2,4-динитрофенил)пиперидина. Показано, что в отличие от уже опубликованных данных реакция протекает с формированием побочных продуктов, в частности, конденсированного гетероцикла – 1,2,3,4-тетрагидропиридо[1,2-a]бензимидазола. Последний образуется при проведении процесса в кислых условиях при высоких температурах, конкурируя с другим побочным процессом – хлорированием.
Canadian Society of Vertebrate Palaeontology Annual Meeting Abstracts 2023
Authors: Murray Alison M , Holmes Robert B. , Powers Mark J.
Published: May 2023

n/a
PANORAMA DA INCLUSÃO EDUCACIONAL DE ALUNOS COM DEFICIÊNCIA NOS ANOS INICIAIS DA REDE PÚBLICA MUNICIPAL DE BELÉM
Authors: Mesquita Amélia Maria Araújo , De Castro Kelly Paixão
Published: May 2023

O presente artigo se propõe a apresentar um mapeamento da inclusão de alunos com deficiência nos anos iniciais da rede municipal de Belém considerando a relação entre a matrícula e o atendimento educacional especializado em sala de recursos multifuncionais. Para tanto, por meio da análise documental, identificamos, com base no ano de 2016, o número de alunos incluídos por tipo de deficiência, distrito e escola em que estão matriculados, bem como foi possível mapear o número de professores do Atendimento Educacional Especializado e de Sala de Recurso Multifuncional em funcionamento. A partir dos dados, identificou-se que há maior predominância de alunos incluídos no Distrito DAGUA, sendo estes em sua maioria com deficiência intelectual. Sobre o AEE, constatou-se uma espécie de “superlotação” tendo em vista o proporcional de alunos com deficiência por professor especializado.
ANÁLISE DA DECISÃO DO SUPREMO TRIBUNAL FEDERAL NA ADPF 186/DF E SUA REPERCUSSÃO NA LEI DE COTAS
Authors: Pimenta Alexandre Jorge
Published: May 2023

No ano de 2004 a Universidade de Brasília passou a adotar dois sistemas de ingresso aos seus cursos, sendo que um deles seria o sistema de cotas com critérios socioeconômicos e étnico-raciais. A adoção de tal sistema provocou diversos debates para além do âmbito acadêmico, visto que o partido político DEM ajuizou junto ao Supremo Tribunal Federal a ADPF nº 186/DF questionando se os critérios utilizados pela Instituição estariam de acordo com o estabelecido pela Constituição Federal de 1988. Ao fim do julgamento o STF decidiu pela constitucionalidade da política de cotas, sendo que o relatório final contribuiu para a elaboração da Lei nº 12.711/2012, também conhecida como a Lei de Cotas.
INTOLERÂNCIA RELIGIOSA NO CONTEXTO ESCOLAR
Authors: Rosário Maria José Aviz do , Rosário Luiz Felipe Gonçalves do
Published: May 2023

Este artigo é fruto de estudos e pesquisas realizados no âmbito do Programa Conexões de Saberes e pretende apresentar e refletir sobre alguns aspectos do contexto escolar brasileiro que contribuem para a disseminação das práticas de intolerâncias, sobretudo de intolerância religiosa. Foi elaborado tendo por base a revisão bibliográfica especializada em perspectiva histórico-educacional. Os estudos apontam que a intolerância religiosa no contexto escolar é fruto da intolerância religiosa que grassa na sociedade brasileira e que teve sua gênese no processo de colonização se espraiando para todos os tempos e atravessou a escola brasileira, sobretudo a pública, apesar da presença de instrumentos legais como a Constituição, o Código penal e a Lei de Diretrizes e Bases da Educação Nacional- LDB se colocarem diamentralmente contra essas práticas.
MEDIAÇÃO DE LEITURA: A EXPERIÊNCIA DO “PROJETO CIRCUITO DE LEITURA: LENDO PARA SER FELIZ”
Authors: Rosário Maria José Aviz do , Rocha Taynan De Moraes
Published: May 2023

O presente trabalho é resultante de um recorte do meu trabalho de conclusão de curso cujo o objetivo principal é apresentar o Projeto Circuito de Leitura: lendo para ser feliz, buscando conhecer sua a história e a importância dos mediadores de leitura para a formação de leitores e leitoras na comunidade. Além deste objetivo geral, o trabalho se propõe mais especificamente a refletir quais os conceitos de leitura e mediação de leitura que os mediadores do projeto possuem tendo em vista os seus papéis como incentivadores da leitura. Para isto, o referido trabalho foi elaborado metodologicamente por meio de pesquisa da abordagem qualitativa e de cunho bibliográfico. Para além dos teóricos, utilizou-se documentos como os Parâmetros Curriculares e os Relatórios do Projeto Circuito de leitura: lendo para ser feliz, do Programa Conexões de Saberes. Para maior fundamentação e movimento ao trabalho foi necessário, ouvir os mediadores envolvidos no projeto por meio de entrevistas semiestruturadas. Posto isso, destaca-se a importância do Projeto de Mediação de Leitura através da atuação dos mediadores de leitura, devido contribuírem para a vida de jovens de comunidades no sentido de propiciar a chance de se desenvolverem como leitores cidadãos. Assim sendo, conclui-se que muitos são os benefícios possíveis por meio da mediação de leitura para as comunidades populares, porém, para que as pessoas possam de fato usufruir destes bens, é necessário que sejam estimuladas para o gosto pela leitura, e assim, entender sua funcionalidade, e o quanto, por meio da leitura podem se tornar autônomas e felizes.
Significados sobre metodología de la investigación en programas de doctorado en Educación. Una exploración desde su componente curricular
Authors: Jiménez Mora José , Moreno Bayardo María , De la Cruz Torres Frías José
Published: May 2023

Este artículo aborda los significados del concepto «metodología de la investigación», inferidos a partir de la revisión de los planes y programas de estudios de tres programas de doctorado en Educación de México. Estos doctorados, además de diseños curriculares específicos, cuentan con profesores consolidados en procesos de investigación y varias generaciones de estudiantes formados(as). En este documento se explica el análisis realizado de los planes y programas, basado en la delimitación e interpretación de unidades de contenido presentes en el discurso curricular relacionadas con el concepto metodología de la investigación. Producto de lo anterior, se enuncian algunos hallazgos acerca de significados dados en cada programa doctoral a elementos clave de este concepto, junto con una mirada comparativa entre los tres programas, en el marco de estudio de la formación para la investigación educativa. Como parte de los resultados se encontraron nueve grandes atribuciones de significado al concepto, con distinto nivel de afinidad entre estos programas. Se comparten las concepciones de que la metodología de la investigación es más una lógica de generación de conocimiento que una definición de técnicas, así como el hecho de que comprende bases epistemológicas para métodos particulares. En todos los programas se sostiene, asimismo, el carácter de la metodología de la investigación como objeto de conocimiento y de formación en constante evolución.
La representación de los procesos fonológicos: a propósito del descenso vocálico del quechua
Authors: Pérez Jorge Iván
Published: May 2023

La representación teórica dew1 objeto o de un proceso constituye la hipó­tesis del investigador sobre qué es tal objeto o cómo se lleva a cabo dicho proceso. La fonología es un área privilegiada en la que se puede observar esto con facilidad: la ontología fonológica -el conjunto de objetos que confor­man los procesos o fenómenos fonológicos-no está dada a priori ; debe ser construida teóricamente por el lingüista con el fin de dar cuenta de los daros de que dispone. En esta presentación, muestro distintas maneras de representar el conocido fenómeno fonológico de descenso o apertura de las vocales del quechua, desde la concepción de Trubetzkoy hasta la teoría de laoptimalidad.
Elementary Steps in Steady State Kinetic Model Approximation for the Homo-Heterogeneous Photocatalysis of Carbamazepine
Authors: Rytwo Giora , Shahar Yuval
Published: May 2023

Elucidating physicochemical processes in the degradation of pollutants may optimize their removal from water sources. This work presents a set of elementary steps in the photocatalytic degradation of carbamazepine (CBZ), assuming a steady state approximation in an Advanced Oxidation Process (AOP) combining short-wave ultraviolet radiation (UVC), homogeneous reagent (H2O2) and heterogeneous (TiO2) catalyst. Elementary steps include excitation of both reagent/catalysts by UVC photons, adsorption of CBZ on the excited TiO2, or its oxidation by hydroxyl radicals. Assuming the steady state approximation on the intermediate products (excited TiO2, CBZ- excited TiO2 complex, and hydroxyl radicals), leads to rate laws for degradation of CBZ, in which UVC radiation, TiO2, and H2O2 are pseudo first order at all concentrations or intensities having no direct influence on CBZ pseudo-order, whereas CBZ shifts from pseudo first order at low concentrations to pseudo-zero order at high concentrations. Several experiments to test the mechanism were conducted, by varying CBZ, H2O2, and TiO2 concentrations, and UVC radiation intensities. Measured results indeed fit the suggested mechanism for the first three, but irradiation intensity appears to shift CBZ influence from pseudo-second to pseudo-first order with increased intensities. Corrected elementary steps are proposed to fit the results.
Imagined Speech Classification Using EEG and Deep Learning
Authors: Abdulghani Mokhles M. , Walters Wilbur L. , Abed And Khalid H.
Published: May 2023

In this paper, we propose an imagined speech-based brain wave pattern recognition using deep learning. Multiple features were extracted concurrently from eight-channel Electroencephalography (EEG) signals. To obtain classifiable EEG data with fewer number of sensors, we placed the EEG sensors on carefully selected spots on the scalp. To decrease the dimensions and complexity of the EEG dataset and to avoid overfitting during the deep learning algorithm, we utilized the wavelet scattering transformation. A low-cost 8-channel EEG headset was used with MATLAB 2023a to acquire the EEG data. The Long-Short Term Memory Recurrent Neural Network (LSTM-RNN) was used to decode the identified EEG signals into four audio commands: Up, Down, Left, and Right. Wavelet scattering transformation was applied to extract the most stable features by passing the EEG dataset through a series of filtration processes. Filtration has been implemented for each individual command in the EEG datasets. The proposed imagined speech-based brain wave pattern recognition approach achieved a 92.50% overall classification accuracy. This accuracy is promising for designing a trustworthy imagined speech-based Brain-Computer Interface (BCI) future real-time systems. For better evaluation of the classification performance, other metrics were considered, and we obtained 92.74%, 92.50% and 92.62% for precision, recall, and F1-score, respectively.
On the Applicability of Quantum Machine Learning
Authors: Raubitzek Sebastian , Mallinger Kevin
Published: May 2023

In this article, we investigate the applicability of quantum machine learning for classification tasks using two quantum classifiers from the Qiskit Python environment: the Variational Quantum Classifier (VQC) and the Quantum Kernel Estimator (QKE). We evaluate the performance of these classifiers on six widely known and publicly available benchmark datasets and analyze how their performance varies with the number of samples in artificially generated test classification datasets. Our results demonstrate that the VQC and QKE exhibit superior performance compared to basic machine learning algorithms such as advanced linear regression models (Ridge and Lasso). However, they do not match the accuracy and runtime performance of sophisticated modern boosting classifiers like XGBoost, LightGBM, or CatBoost. Therefore, we conclude that while quantum machine learning algorithms have the potential to surpass classical machine learning methods in the future, especially when physical quantum infrastructure becomes widely available, they currently lag behind classical approaches. Furthermore, our findings highlight the significant impact of different quantum simulators, feature maps, and quantum circuits on the performance of the employed quantum estimators. This observation emphasizes the need for researchers to provide detailed explanations of their hyperparameter choices for quantum machine learning algorithms, as this aspect is currently overlooked in many studies within the field.\\ To facilitate further research in this area and ensure the transparency of our study, we have made the complete code available in a linked GitHub repository.
Chemical Fertilization Alters Soil Carbon in Paddy Soil through the Interaction of Labile Organic Carbon and Phosphorus Fractions
Authors: Aumtong Suphathida , Chotamonsak Chakrit , Pongwongkam Paweenuch , Cantiya Kanchana
Published: May 2023

The influence of long-term chemical fertilization in paddy soils is based on the interaction between labile carbon and phosphorus fractions and how this influences soil organic carbon (SOC). Four soil depths (0–30 cm) were analyzed in this study. Easily oxidized organic carbon components, such as permanganate oxidized carbon (POXC) and dissolved organic carbon (DOC), and other physicochemical soil factors were evaluated. The correlation and principal component analyses were used to examine the relationship between soil depth and the parameter dataset. The results showed that Fe-P concentrations were greater in the 0–5 cm soil layer. DOC, inorganic phosphate fraction, and other soil physiochemical characteristics interacted more strongly with SOC in the 0–5 cm soil layer, compared to that in the 10–15 cm layer, influencing soil acidity. An increase in DOC in the 0–5 cm soil layer had a considerable effect on lowering SOC, consistent with P positively correlated with POXC, but negatively with SOC and water-soluble carbon (WSC). The changes in SOC could be attributed to the relationship between DOC and inorganic phosphate fractions (as Fe-P) under a specific soil pH condition. An increase in soil DOC could be caused by changes in the P fraction and pH. The DOC:Avai. P ratio could serve as a compromise for the C and P dynamic indicators. The soil depth interval is a critical element that influences these interactions. Agricultural policy and decision-making may be influenced by the P from chemical fertilization practices, considering the yields and environmental effects.
White Box Watermarking for Convolution Layers in Fine-Tuning Model Using the Constant Weight Code
Authors: Kuribayashi Minoru , Yasui Tatsuya , Malik Asad
Published: May 2023

Deep neural network (DNN) watermarking is a potential approach for protecting the intellectual property rights of DNN models. Similar to classical watermarking techniques for multimedia content, the requirements for DNN watermarking include capacity, robustness, and transparency, and other factors. Studies have focused on robustness against retraining and fine-tuning. However, less important neurons in the DNN model may be pruned. Moreover, although the encoding approach in renders DNN watermarking robust against pruning attacks, the watermark is assumed to be embedded only into the fully connected layer in the fine-tuning model. In this study, we extended the method such that the model can be applied to any convolution layer of the DNN model and designed a watermark detector based on a statistical analysis of the extracted weight parameters to evaluate whether the model is watermarked. Using a nonfungible token mitigates the overwriting of the watermark and enables checking when the DNN model with the watermark was created.
Research on Chilling Requirement and Physiological Mechanism of Prunus mume
Authors: Zhang Yuhan , Ma Kaifeng , Li Qingwei
Published: May 2023

Low-temperature plays a vital role in the growth and development of woody plants. In this research, based on the way of artificial low temperature to break dormancy, the Utah model was used to determine the chilling requirements of four early-flowering Prunus mume cultivars, which were widely planted in Henan area of China. At the same time, changes in the carbohydrates, antioxidant enzyme activities, and endogenous hormone contents of the flower buds (FBs) of the above P.mume cultivars were measured during the low-temperature storage process, and the physiological changes of the four cultivars during the low-temperature induction period were explored. The main research conclusions are as follows: (1) The chilling requirements of ‘Gulihong’, ‘Nanjing gongfen’, ‘Zaoyudie’ and ‘Zaohualve’ were 408CU, 396CU, 372CU and 348CU respectively. All the P.mume cultivars belonged to low chilling demand cultivars. The P.mume also bloomed 4 months earlier (2) During the process of releasing dormancy at low temperature, the contents of soluble sugar (SS) in the osmoregulation system of the four Prunus mume cultivars showed an upward trend, while the contents of starch (ST) basically showed an opposite trend with the increase of chilling. The superoxide dismutase (SOD) activity in the FBs of each cultivar gradually decreased with the accumulation of cold and maintained at a low level, the peroxidase (POD) activity showed the opposite trend, and the dynamic changes of the catalase (CAT) activity generally showed a trend of first increasing and then decreasing. The content of abscisic acid (ABA) showed a trend of increasing first and then decreasing as a whole. The changing trend of gibberellin (GA3) content was similar to that of ABA. In addition, it was found that before dormancy was released, the SS and Pro contents of cultivars with lower chilling requirements and early FB germination were significantly higher than those of other cultivars with higher chilling requirements, and the contents of ST and SP were lower. The cultivars with higher chilling requirement and late flower bud germination had higher ABA content, lower GA3 contents, and their enzyme activities were significantly higher than those of the cultivars with lower chilling requirement. Therefore, the changes in the content of various substances in FBs are related to the amount of cooling required by the cultivar and the sooner or later the FBs germinate, and the changes in their contents can be used as one of the indicators for judging the dormancy process of FBs.
Livelihoods and Perceptions of Climate Change among Dairy Farmers in the Andes: Implications for Climate Education
Authors: Vargas-Burgos Julio C , Heredia-R Marco , Torres Yenny , Puhl Laura Elena , Heredia Biviana N , Cayambe Jhenny , Hernán-González Julio , Torres Alexandra , Luna Marcelo , Toulkeridis Theofilos , Torres Bolier
Published: May 2023

Climate change mainly affects production and consumption systems, such as: food, livelihoods, production (e.g., reduced milk production), water, and land use. The role of local knowledge has been recognized as important for decision-making under changing circumstances. This study was conducted in the northern part of the Ecuadorian Andes using a sample of 170 dairy-cattle-producing households. The objectives were: i) to characterize the rural livelihoods of dairy cattle farmers, ii) to evaluate access to climate information and perceptions of climate change, and iii) to determine the relationship between livelihoods and perceptions of climate change. Significant differences were identified between the groups evaluated in relation to the dairy farmers’ livelihoods. In addition, 85.29% of the respondents mentioned that climate information is important, but 67.83% do not trust the sources of information. It was found that there is a significant relationship between the level of education and age with the variables of climate change perceptions. This combined knowledge allows people to promote agri-environmental and educational policies to achieve climate literacy at a rural level.
Can New Energy Demonstration City Policy Promote Green and Low-Carbon Development? Evidence From China
Authors: Chen Bo , Jin Feng , Li Guangchen , Zhao Yurong
Published: May 2023

Developing new energy is critical to China's green and low-carbon development. And the New Energy Demonstration City Policy (NEDCP) is a vital innovation policy that inspires the development of new energy. Is the NEDCP facilitating green and low-carbon development, if so, how? Employing unbalanced panel data from 2003 to 2017, the impact of NEDCP on green and low-carbon development was studied by using the "difference in difference" (DID) model. We find that this policy can take significantly role. After various robustness tests, our results are still valid. According to the heterogeneity analysis, non-resource and non-old industrial base cities have a greater positive impact from this policy. The mechanism analysis denotes that the positive policy effect works through upgrading the industrial structure and stimulating urban innovation. The substantial empirical evidence presented in this article supports the continued promotion and implementation of new energy demonstration cities.
Triggering of an Epidemic Outbreak by Long-Range Atmospheric Transport of Bio-Aerosols. Application to a Hypothetical Case for COVID-19
Authors: Rowe Bertrand R. , Mitchell J. Brian A. , Canosa André , Draxler Roland
Published: May 2023

In the present work, we investigate the possibility that long-range airborne transport of infectious aerosols could initiate an epidemic outbreak at distances downwind beyond one hundred kilometers. For this, we have developed a simple atmospheric transport box-model which, for a hypothetical case of a COVID-19 outbreak, was compared to a more sophisticated 3-dimensional transport-dispersion model (HYSPLIT) calculation. Coupled with an extended Wells-Riley description of infection airborne spread, it shows that, the very low probability of outdoor transmission can be compensated by high numbers and densities, such as occurs in large cities, of infected and susceptible people in the source upwind and in the target downwind respectively. This may result in the creation of a few primary cases. It is worth pointing out that the probability of being infected remains very small at the individual level. Therefore, this process alone, which depends on population sizes, geography, seasonality and meteorology, can only “trigger” an epidemic which could then spread by the standard infection routes
The Role of Blood Oxygen Level Dependent Signal Variability in Pediatrics: A Systematic Review
Authors: Dinatolo Michael Francesco , Pur Daiana Roxana , Eagleson Roy , De Ribaupierre Sandrine
Published: May 2023

Background: As pediatric BOLD SV is relatively novel, there is a need to provide a foundational framework that gives researchers an entry point into engaging with the topic. This begins with clarifying the definition of BOLD variability by identifying and categorizing the various metrics utilized to measure BOLD SV; Methods: A systematic review of the literature was conducted. Inclusion criteria were restricted to studies utilizing any metric of BOLD signal variability (BOLD SV) and with individuals younger than 18 in the study population. The definition of BOLD SV was any measure of intra-individual variability in the BOLD signal. Five databases were searched: Psychinfo, Healthstar, Medline, Embase, and Scopus; Results: Seventeen observational studies, including male (n =1796) and female (n =1324) pediatric participants were included. Eight studies quantified variability as the amount of deviation from average BOLD signal, 7 used complexity-based metrics, 3 used correlation measures of variability, and 1 used structure of the hemodynamic response function. Ten methods of quantifying signal variability were identified. Associations and trends in BOLD SV were commonly found with age, factors specific to mental and/or neurological disorders like attention deficit disorder, epilepsy, psychotic symptoms, and performance on psychological and behavioral tasks. Conclusions: BOLD SV is a potential biomarker of neurodevelopmental and neurological conditions and symptom severity in mental disorders for defined pediatric populations. Studies that establish clinical trends and identify the mechanisms underlying BOLD SV with a low risk of bias are needed before clinical applications can be utilized by physicians
The Impact of the Association Between Structural Changes in Glaucoma as a Primary Element in Visual Perception and Audi-Tory Function on the Diagnostic Management of Glaucomatous Disease
Authors: Neacsu¹´² Alina Mihaela , Anton³ Nicoleta , Lapusneanu² Lucian , Stoian² Valentina , Andrei² Maria Cristina , Cosman² Mihaela , Ferechide² Dumitru
Published: May 2023

Background. In the last decade, it was concluded that glaucomatous optic neuropathy is part of the neurodegenerative diseases in which destructive neuronal lesions are located not only in the structure of the retina, but they are also present at the level of the central visual and nervous pathways. Patients with Primitive Open Angle Glaucoma may have experienced changes such as sensorineural hearing loss as well as balance changes. The purpose of this study is to evaluate the degree of involvement of the auditory system in patients with glaucoma, the structural changes in the optic nerve and, to establish correlation between the hearing loss and structural changes in the optic nerve. The subjects included in the study are grouped as follows: a group of patients with glaucoma that will be compared to a group of patients without glaucoma only as well as identi-fy-ing the evolution of structural changes in optic nerve to patients with glaucoma and to normal patients. Material and methods. It is a prospective, cross-sectional study on 32 eyes of 16 subjects with Primitive Open Angle Glaucoma in a study group and 24 eyes of 12 healthy subjects in con-trol group with a mean age of 62 years in both groups. Both groups underwent ophthalmo-logical, audiological and radio imaging evaluation: Pure-tone audiometry (PTA) were recorded, oph-thalmologic evaluations according to a standardized protocol and MRI cerebral examination was performed. Results: In the Study group patients, compared to the Control group, the average lev-els of the left PTA, the cup/disc (C/D) area in both eyes, the C/D ratio in both eyes are in-creased. The mean level of Retinal nerve fiber layer (RNFL) mean thickness was slightly lower in patients with glaucoma. Multivariate analysis demonstrates that gender can be a good predictor of C/D area, gender and age can be good predictors of PTA both eyes and C/D ratio in the right eye, and gender, age and background can be good predictors of disc area in the left eye. Conclu-sions: Pa-tients with Primitive Open Angle Glaucoma show changes in audiometry test in correla-tion with ophthalmological parameters demonstrating that the auditory system can be affected in Primitive Open Angle Glaucoma. This study emphasizes the problem of interdisciplinarity in medicine with the aim of ensuring the quality of life of patients with glaucoma. A good collabora-tion between ophthalmologist and otolaryngologist will be very useful for these patients.
Recycling Silicon Waste from Photovoltaic Industry to Prepare Yolk-Shell Si@void@C Anode Materials for Lithium-Ion Batteries
Authors: Ji Hengsong , Liu Zhijin , Li Xiang , Li Jun , Yan Zexuan , Tang Kai
Published: May 2023

Silicon has a theoretical specific capacity of 4200 mAh g−1, which is considered to have significant potential for anode materials in lithium-ion batteries (LIBs). However, the volume change that occurs in silicon during charging and discharging affects the development of commercial applications. In this work, a yolk-shell structured Si@void@C anode material has been developed to address this problem. The silicon nanoparticle yolk material is obtained by recycling kerf-loss (KL) Si waste from the photovoltaic industry, the carbon shell is prepared via a hydrothermal process with glucose, and the sacrificial interlayer is Al2O3. The synthesized material is used to fabricate anodes that show a high reversible capacity of 836 mAh g−1 at the current density of 0.1 A g−1 after 100 cycles, with a Coulomb efficiency of 71.4%. This work demonstrates a relatively low-cost approach to turn KL Si waste into value-added materials for LIBs.