bluuebunny/crossref_metadata_2025 huggingface dataset:
D. Ponto: A solução mais efetiva para o registro de ponto de sua empresa
Authors:   , Santos Fabiano dos , Alonso Fábio Henrique , Casagrande Fernando Aparecido Nunes , Sousa Junior Edvan Araújo de
Published: May 2024

O controle da jornada de trabalho é um processo inerente a toda e qualquer empresa, seja ela de pequeno, médio ou grande porte. Para que isso ocorra de forma efetiva, o setor de Recursos Humanos (RH), especificamente o Departamento de Pessoal (DP), diariamente monitora a entrada e saída dos empregados para que ao final do mês possa efetuar o cálculo da folha de pagamento de todos os empregados. A entrada e saída dos empregados interfere em diversos processos e subprocessos da rotina do RH/DP, como por exemplo, no controle do absenteísmo, escala e jornada de trabalho, horas extras, adicional noturno, e a quantidade de horas-homem trabalhadas. Diante de tal importância que o RH/DP desenvolve rotineiramente, o desenvolvimento desse projeto fundamenta-se na solução eficaz da gestão e monitoramento das entradas e saídas dos empregados a fim de inibir fraudes no registro da jornada e dar autenticidade e veracidade para todos os registros efetuados pelos empregados. Ainda sendo, o objetivo principal visa desenvolver uma solução efetiva para o controle e gestão do registro de ponto, com base na Portaria 671, de 8 de novembro de 2021, emitida pelo Ministério do Trabalho e Previdência (MTP), em que busca-se desenvolver um sistema mobile que confere autenticidade por meio da conexão Bluetooth com verificação por meio do IMEI (Código de identificação do celular) ou MAC (Media Access Control ou controle de acesso ao meio); ou por meio do sistema web em que a autenticação ocorrerá por meio da rede local de computadores (rede privada da empresa) ou conexão VPN (Virtual Private Network, ou rede privada virtual) com verificação por meio do IP (Internet Protocol, ou protocolo de rede) ou MAC (Media Access Control ou controle de acesso ao meio). Para execução do projeto pretende-se adotar a metodologia Rational Unified Process (RUP) ou Processo Unificado da Rational, que é um modelo de processo moderno reunindo boas práticas desde a especificação do projeto do software até a entrega final do produto. É esperado, com base na justificativa, objetivo e metodologia deste projeto, a entrega de um protótipo do equipamento que será desenvolvido, e replicado em escala comercial respeitando certificações de qualidade, propriedade intelectual, e registros comerciais, caso necessário, bem como o um aplicativo/programa para dispositivos móveis e computadores, tendo em vista os diferentes níveis: operacional (usuário), tático (administrador) e estratégico (gerencial) na operacionalização e na gestão dos registros. Com base na necessidade do mercado em ter um produto que seja efetivo e confiável no controle e gestão da jornada de trabalho dos empregados espera-se um impacto positivo para todos os envolvidos, principalmente o impacto financeiro no que tange o custo-benefício para empresas na gestão do registro da jornada, na mitigação de fraudes, na solução de problemas e economia em manutenção de equipamentos.
Texture Analysis of Hard Tissue Changes after Sinus Lift Surgery with Allograft and Xenograft
Authors: Mohammad Azimzadeh , Farzad Esmaeili , Narges Bayat , Kasra Rahimipour , Amir Ebrahimpour Tolouei
Published: May 2024

In the realm of dental surgery, implants are essential for replacing missing teeth. To facilitate implant placement, techniques such as bone grafting and sinus lifts are utilized to augment the volume of atrophied alveolar bone in candidates for dental implants. Typically, patients undergo a period of recovery following bone grafts before proceeding with implant placement. This study investigates the efficacy of Cone Beam Computed Tomography (CBCT) in measuring the residual bone volume and assessing bone quality after the healing phase. A texture analysis was conducted on CBCT scans from 42 patients requiring maxillary sinus lift reconstruction. These patients were categorized into two groups based on the type of grafting material used: Xenograft or allograft. The study analyzed the distribution of various texture parameters and conducted a Mann-Whitney U test to identify significant statistical differences between the groups. Results indicated non-normal distributions for specific variables such as Area_S(1,0) and S(1,0)SumOfSqs, while others like S(1,0)Entropy displayed normal distributions. The findings revealed no significant statistical differences in the primary outcomes between the xenograft and allograft groups. However, the average values of the gray shades of pixels in the allograft group were statistically significantly higher compared to the xenograft group, suggesting differences in bone texture post-procedure.
Maternal health in cities: analysis of institutional maternal mortality and health system bottlenecks in Kampala City Uganda, 2016-2021
Authors: Birabwa Catherine , Banke-Thomas Aduragbemi , Waiswa Peter , Semaan Aline , Kananura Rornald Muhumuza , van Olmen Josefien , Beňová Lenka
Published: May 2024

Background

Recent estimates have shown a stagnation in maternal mortality reduction globally. Levels and trends in maternal mortality in urban settings in Africa are of interest due to health system challenges posed by rapid urbanisation. Given the high percentage of births occurring in city health facilities, tracking the institutional maternal mortality ratio (IMMR) can reveal key performance issues. We described the trends in IMMR between 2016 and 2021, and the causes and characteristics of maternal deaths in Kampala, Uganda.

Methods

This retrospective study utilised routine data from all facilities in Kampala that provided childbirth services from 2016 to 2021. Three key variables were used: number of deliveries, live births, and maternal deaths. Additionally, from medical records in three purposively selected hospitals, we extracted information on characteristics of women recorded as maternal deaths and their causes for the period 2016-2021 from death notification and review forms. We conducted descriptive analysis and assessed time trends in IMMR.

Results

For the six-year period, the Kampala-level IMMR was 189/100,000 deliveries (194/100,000 livebirths). The IMMR declined from 213 (2016) to 109/100,000 deliveries in 2019 (p=0.04) and then increased to 258 in 2021 (p=0.12). A review of 358 maternal death records showed that 65% of deaths were women referred from other health facilities, and 47% lived in the surrounding district (Wakiso). Obstetric haemorrhage (44%) and hypertensive disorders in pregnancy (28%) were the most commonly recorded causes of death. Health system factors such as lack of blood and other supplies contributed to 65% of the deaths reviewed.

Conclusions

IMMR in Kampala increased from 2019-2021. Health infrastructure changes and maternal health initiatives potentially accounted for the observed trend by affecting data quality. Referral and facility readiness were underlying reasons for maternal deaths. Addressing bottlenecks in emergency referral processes may contribute to mortality reduction. Further research should determine the relative contribution of key influences on mortality levels and examine the dynamics between women’s care-seeking pathways and service delivery arrangements for emergency obstetric care in urban settings.
La gamificación en el Classcraft para innovar la enseñanza y aprendizaje de la electrotecnia
Authors: Cabezas Pozo Miguel Roberth , Heredia Castillo Jairo Andres , Echeverría Guzmán Ángel Yasmil , Guzmán Hernández Ramón
Published: May 2024

En un entorno caracterizado por el constante desarrollo tecnológico e innovador, la electrotecnia es la base de una sociedad en evolución. Es imprescindible impartir una formación de excelencia en la Unidad Educativa Vicente Fierro (UEVF). El objetivo de la investigación es implementar la gamificación en Classcraft para innovar la enseñanza y aprendizaje de la electrotecnia, formando individuos altamente calificados para el sector industrial y empresarial. Se utilizó una metodología cuantitativa, no experimental, de campo, con nivel descriptivo. Los resultados destacan la falta de recursos didácticos contemporáneos y dispositivos de última generación en las aulas de electrotecnia. La propuesta se erigió como un medio para subsanar las deficiencias observadas y promover un aprendizaje autónomo, fomentando la creatividad e innovación. Se concluye que la gamificación en Classcraft tuvo efectos positivos en los estudiantes, como motivación, aprendizaje lúdico y construcción de conocimientos significativos.
The role of learning strategies on object control skills is reviewed from coordination in children
Authors: Putri Marisadiana , Bakhtiar Syahrial , Bafirman Bafirman , Ihsan Nurul , Pratama Putri Lucy
Published: May 2024

The ability to control objects is an ability that children must master. Mastery of object control is obtained from one of them from the learning process obtained at school. This learning process can provide students with learning strategies. The study aimed to determine the effect of learning strategies and coordination skills on the ability to control objects in children in elementary school. This research method is quasi-experimental, involving 60 male and female students in grade 5, and the sampling technique used is total sampling. The instruments used in this study on object skills used the test of gross motor development 2nd edition subtest. Movement coordination data uses instruments consisting of anthropometry, balance beams, moving sideways, jumping sideways, and eye-hand coordination. The data were analyzed using the two-way analysis of variance (ANOVA) technique with the help of SPSS 26. Based on the research findings, the TGfU learning approach group had the best average score of 33.86 among other groups. The conclusions of this study show that the object control ability of students with low coordination is better if given conventional learning strategies than TGfU, as evidenced by a value (p < 0.05). The conclusion that can be drawn from this study is that TGfU learning strategies influence the ability to control objects in children in elementary school, and there is an interaction between coordination and learning strategies.
Revealing the Effect: How Google Slides Helps Improve Vocational Students' Writing Skills
Authors: Kusumaningrum Dyah Rini , Pratiwi Dwiyani
Published: May 2024

Despite the widespread integration of Google Slides in educational settings, its direct effect on students' writing skills has received limited attention, primarily focusing on students' perceptions rather than measurable outcomes. This research aimed to quantify the impact of Google Slides on enhancing students' abilities to construct descriptive texts, employing qualitative and quantitative methods to provide a comprehensive analysis. Conducted over eight weeks at a Vocational High School in Banyumas, Central Java, the study involved 36 tenth-grade students. Utilizing a mixed-methods design, observations and pre-post test scores were collected to assess the effectiveness of Google Slides in the classroom. The quantitative analysis of pre-and posttest results showed a significant improvement in writing skills (t(35) = -16.095, p < 0.001), indicating that Google Slides positively affects students’ writing capabilities. Qualitative observations further highlighted the tool's broader benefits, including increased motivation, readiness to learn, and enhanced vocabulary among participants. The study thus confirms the significant positive impact of Google Slides on students' writing development and offers insights into its potential as a valuable educational resource.
English Reading Materials in Non-Formal Education: A Need Analysis
Authors: Pratiwi Ayu , Priyana Joko
Published: May 2024

Conducting a needs analysis is imperative for customizing educational content to align with students' specific learning prerequisites, especially in the realm of reading skill development, which is acknowledged as a challenging domain. This study investigates into the necessity for tailored English reading materials within non-formal educational frameworks, with a focus on junior high students at the Gosmart Institution in Yogyakarta. Utilizing a combination of surveys and interviews, data was collected from 50 students, revealing a strong inclination towards vocabulary enhancement and the extraction of detailed information from texts as their primary learning objectives. The analysis uncovers students' difficulties with presentation activities, largely due to confidence issues, alongside a pronounced preference for reading materials enriched with illustrative and social media images. Additionally, the study points out the scarcity of authentic reading resources, which hampers the effectiveness of teaching strategies. The findings advocate for the integration of these insights into the development of English reading materials, proposing a targeted approach to ameliorate reading instruction and address the highlighted educational needs. This study underscores the importance of adapting educational resources to meet learner preferences and challenges, thereby enhancing the overall teaching and learning experience in reading skills development.
Long-Term Trends in Mosquito Vector Populations and Their Impact on Yellow Fever Outbreaks in Atlantic Forest Fragments of Rio De Janeiro, Brazil (2016–2021)
Authors: Olsson Freitas Silva Shayenne , Ferreira de Mello Cecilia , Figueiró Ronaldo , Carbajal-de-la-Fuente Ana Laura , Dias Rayane , Alencar Jeronimo
Published: May 2024

Among all living beings, mosquitoes account for the highest number of human fatalities. Our study aimed to determine mosquito egg abundance fluctuation from 2015 to 2020, in order to observe which years had the highest mosquito vector densities and whether they coincided with yellow fever virus outbreaks in both human and nonhuman primates. The study area included Atlantic Forest fragments in the state of Rio de Janeiro. Studies from the Diptera Laboratory at FIOCRUZ were selected and compared along a timeline period of the field collections. The highest peak in egg abundance from the analyzed studies was observed from 2016 to 2017 and from 2015 to 2016. The lowest egg abundance was during the collection periods from 2018 to 2019 and 2019 to 2020. The species with the highest abundance throughout all the periods of the studies analyzed was Haemagogus leucocelaenus, representing 87% of all epidemiological species identified. The species with the lowest abundance was Hg. Janthinomys, representing only 1%. Monitoring the population of mosquitoes is imperative for disease surveillance, as the rise in specimens of various vector species directly impacts the occurrence of yellow fever cases in both nonhuman primates and human populations.
Prophylactic efficacy of aqueous extract of unripe pawpaw (Carica papaya) fruit on hematological and biochemical parameters in induced hyperbilirubinemia Wistar rats
Authors: Augustine Friday Williams  , Sunday Adakole Ogli  , Dickson Owoicho Ochalefu  , Olusupo Stephen Adeniyi
Published: May 2024

This research offers a comprehensive examination of hyperbilirubinaemia, characterized by elevated levels of bilirubin in the bloodstream leading to jaundice. It presents a prevalent challenge during the neonatal phase, as bilirubin can accumulate in various body parts resulting in potential neurotoxicity. The discussion encompasses factors influencing bilirubin production, conjugation, and elimination in the organism, along with an overview of the causes and symptoms of hyperbilirubinaemia. The study delves into the potential advantages of utilizing Carica papaya, a tropical fruit, for the prevention of hyperbilirubinaemia. Traditional medical approaches for managing this condition are linked to numerous adverse effects, hence the necessity to develop more affordable, easily accessible, and efficacious drugs with minimal or no side effects. Blood samples were procured and subjected to full blood cell count analysis via an automated hematologic analyzer, while serum samples were utilized for quantifying liver enzymes and bilirubin employing a spectrophotometric technique. Additionally, the weight of visceral organs was determined using a Mettler weighing balance. The outcomes of an experimental study conducted on rodents revealed that pretreatment with Carica papaya extract notably decreased bilirubin and liver enzyme levels in the subjects. This highlights the potential role of Carica papaya in the preventive management of hyperbilirubinaemia, underscoring the imperative for further investigation in this domain. In essence, this research serves as a valuable repository of knowledge for healthcare practitioners and researchers keen on addressing hyperbilirubinaemia.
Penerapan Kuis Interaktif untuk Meningkatkan Minat Belajar Matematika
Authors: Azhari Alya , Adhimah Olivia Khufyatul , Huda Syaiful
Published: May 2024

Penelitian ini bertujuan untuk mengatasi permasalahan pada proses pembelajaran pasca Covid 19 yaitu rendahnya minat belajar matematika pada peserta didik. penerapan kuis interaktif diharapkan mampu meningkatkan minat belajar matematika. Jenis penelitian ini adalah PTK (Penelitian Tindakan Kelas). Subjek penelitian ini adalah 36 peserta didik kelas 7 SMPN 3 Candi. Teknik pengumpulan data pada penelitian ini menggunakan angket. Diperoleh hasil penelitian  adanya peningkatan minat belajar matematika peserta didik yang ditunjukkan dengan meningkatnya banyak peserta didik dengan minat belajar tinggi dan menurunnya banyak peserta didik dengan minat belajar rendah. Pada siklus I tidak ditemukan peserta didik dengan minat belajar rendah, terdapat 20 peserta didik dengan minat belajar sedang dan 16 peserta didik dengan minat belajar tinggi sedangkan pada siklus II tidak ditemukan peserta didik dengan minat belajar rendah, terdapat 14 peserta didik dengan minat belajar sedang dan 22 peserta didik dengan minat belajar tinggi.
Efektivitas Penggunaan Model Project Based Learning Berbasis STEM Pada Materi Fluida Statis untuk Meningkatkan Kemampuan Berpikir Tingkat Tinggi Peserta Didik di Kelas XI MIA SMA Negeri 8 Ambon
Authors: Radja Udju Delans Fabiyolla Putri , Limba Anatasija , Tamaela Elsina
Published: May 2024

This study aims to determine the effectiveness of using the STEM-project based learning model to improve students' high-level thinking skills in learning static fluid material in class XI MIA SMA Negeri 8 Ambon. This type of research is quantitative with the research design One Group Pretest-Posttest Design. The subjects in this study were 17 class XI MIA students at SMA Negeri 8 Ambon. Research data were collected using test and non-test instruments (LKPD and response questionnaires). The results of the analysis show that the ability to think at a higher level before using the STEM-PjBL model is less qualified with an average achievement score of 25.3. After using the STEM-PjBL model, the qualifications were good with an average achievement score of 74.9. An increase in higher order thinking skills is obtained by normalizing the gain of 0.7 which is in the high qualification. Testing the effectiveness of using the Paired Sample T-Test showed that there was a difference in the average high-level thinking skills of students before and after using the STEM-PjBL model with a Sig. (2-tailed) is 0.000, this means that the value is 0.000 <0.05, so it can be concluded that the STEM-PjBL model is effective for improving the high-level thinking skills of class XI MIA students in static fluid material
Obesità: una malattia recidivante, anche dopo trattamento chirurgico
Authors: Vinciguerra Federica , Di Stefano Carla , Piazza Luigi , Frittitta Lucia
Published: May 2024

Obesity is a complex, chronic, and relapsing disease. It’s a major risk factor for numerous non-communicable illnesses, such as type 2 diabetes, cardiovascular disease, and cancer. Bariatric surgery remains the most effective treatment for obesity. However, even after surgery, some patients struggle with weight regain or insufficient weight loss. This article explores the reasons behind a poor response to bariatric surgery and examines current and emerging treatment options for this persistent health concern.
Analysis and mitigation of power quality (PQ) issues in 0.3MW solar photovoltaic system (SPV) connected to grid with MPPT tracker and controlled load using PSCAD software
Authors: Deshmukh Akshay N. , Chandrakar Vinod K.
Published: May 2024

The escalating global demand for distributed generation systems has driven the widespread integration of Solar Photovoltaic (PV) system into the distribution grid. This paradigm shift, while promising in meeting energy demands, introduces intricate power quality challenges within distribution systems. This research deals with the comprehensive analysis and strategic mitigation of PQ issues of 0.3MW solar PV system, featuring advanced components like an MPPT tracker and a controlled load. Utilizing PSCAD software for simulation, the study incorporates vital input parameters like irradiance and temperature to generate 0.3MW power. The generated power undergoes a meticulous transformation process through boost converter, ensuring both voltage regulation and Power Point Tracking. The regulated DC power is then seamlessly supplied to the voltage source inverter, facilitating its supply to the Point of Common Contact (PCC), where both the conventional grid and the controlled load are intricately connected. The study employs advanced techniques, including FFT analysis to measure THD at the inverter output. Additionally, an in-depth examination of voltage imbalances adds further granularity to the power quality assessment. The THD values for inverter current and voltage are systematically evaluated through FFT analysis, offering insights into the harmonic characteristics of the system. As a strategic measure to mitigate THD and enhance overall power quality, a Static Var compensator is introduced at the inverter output. This intervention proves effective, showcasing a substantial reduction in THD levels. The research contributes significantly to the understanding and management of PQ challenges associated with the integration of solar PV systems in distributed generation scenarios. Through its comprehensive analysis and targeted mitigation strategies, the study provides valuable guidance for ensuring integration of renewable energy sources into the evolving landscape of modern power systems.
Die analytische Großgruppe
Authors: Fossel Florian
Published: May 2024

Analytische Großgruppen werden im Folgenden vor allem in Hinsicht auf ihr kulturschaffendes Potenzial betrachtet. Wenn es gelingt, regressive, chaotische Prozesse gemeinsam zu durchleben, in Dialog zu kommen sowie Irrationales zu begreifen und ins bewusste Denken zu integrieren, kann sich die Großgruppe in einen hochsensiblen Denkapparat mit der Möglichkeit zur sozialen Einsicht und Wachstum wandeln. Aus gruppenanalytischem Blickwinkel wird das Individuum stets in Beziehung zu anderen gesehen, das Ich ist nicht vom Wir zu trennen und dementsprechend betrachten wir den menschlichen Mind/Geist als einen Prozess, der nicht abgeschlossen in einzelnen Individuen, sondern zwischen Personen, so auch zwischen den Mitgliedern einer Großgruppe, stattfindet.
Adaptive features of winter triticale accessions from the VIR collection
Authors: Garaeva N. Sh. , Ponomarev S. N. , Ponomareva M. L.
Published: May 2024

Background. In the context of global climate change, the study and development of genetic material with environmental plasticity and stability in the manifestation of its traits becomes relevant. The scientific and practical results achieved in triticale breeding place this crop among the most popular cereals in terms of economic importance. However, the main problem for the use of triticale in breeding practice is its limited genetic resources.

Materials and methods. The research materials were 161 winter triticale (× Triticosecale Wittm. ex A. Camus) accessions from the global collection of VIR. The study and breeding-oriented assessment of the material were based on conventional breeding techniques and carried out according to the guidelines approved by VIR with minor amendments. The obtained research data underwent statistical analysis using the method by A. V. Kilchevsky and L. V. Khotyleva.

Results. Environmental and genetic parameters were analyzed under the conditions of the Middle Volga Region of Russia. Genotypes were identified for their high general adaptability, i. e., securing the highest average yield in the entire set of environments. Cultivars were also selected for their least variable high yields under the impact of weather conditions. The analysis of the studied set of accessions showed that both high-yielding and low-yielding genotypes were stable. The character’s mean value and its environmental sensitivity were relatively independent and could be incorporated in one genotype in various combinations. This finding can be used in the process of triticale breeding.
Evaluation of aluminum tolerance diversity in Avena sativa L. from the VIR collection
Authors: Loskutov I. G. , Blinova E. V. , Novikova L. Yu.
Published: May 2024

Background. Oat is an important food and feed cereal crop in Russia. The area under oats is 10 million ha worldwide, and 3 million ha in Russia. Acid soils with excessive content of exchangeable aluminum occupy almost every third hectare in the exUSSR territory. Oats are relatively resistant to unfavorable soil factors. Among cereal crops, oat is second only to rye and triticale in terms of resistance to exchangeable Al forms. Despite the crop’s high environmental plasticity, an important condition for obtaining sustainable oat yields is the development of new cultivars with resistance to adverse environmental factors, including metal toxicity and high soil acidity.

The objective of this work was to search for oat cultivars resistant to soil stressors (excess of Н+ and Al3+) for use in breeding for edaphic resistance.

Materials and methods. The research material included 687 oat accessions from the VIR global plant genetic resources collection. The accessions underwent laboratory evaluation of their aluminum tolerance at the initial growth and development stages using the method of measuring radicle growth after the exposure to aluminum stress. Reproducibility of the used modification of the method was mathematically proved.

Results and discussion. Significant variation in the resistance to the studied stressor was observed among the accessions. The regions acting as sources of valuable aluminum resistance genes were identified for the crop. The accessions selected for their high resistance to exchangeable aluminum can be used in breeding programs to develop high-yielding oat cultivars with edaphic resistance.
Composition of high-molecular-weight glutenin subunits and gluten quality in wheat lines with alien genetic material
Authors: Orlovskaya O. A. , Vakula S. I. , Khotyleva L. V. , Kilchevsky A. V.
Published: May 2024

Background. High-molecular-weight glutenin subunits (HMW-GSs) make the greatest contribution to the formation of baking properties in bread wheat (Triticum aestivum L.). Glutenin polymorphism of bread wheat relatives is significantly richer than in cultivated varieties. The objective of this work was to identify the HMW-GS composition and assess the gluten quality of bread wheat lines with introgressions of alien genetic material.

Materials and methods. We studied the parental varieties of spring bread wheat, accessions of the tetraploid and hexaploid Triticum L. species, and 19 introgressive lines produced with their participation. Glutenins were separated using sodium dodecyl sulfate polyacrylamide gel electrophoresis and HMW-GSs were identified using the Payne nomenclature system. Gluten quality was determined in accordance with GOST 13586.1-68 (the 2017–2019 and 2021–2022 growing seasons). Data processing was performed using the Statistica 10.0 and MS Excel software packages.

Results and conclusion. HMW-GSs uncharacteristic of T. aestivum cultivars were identified in the studied accessions of T. dicoccoides (Körn. ex Aschers. et Graebn.) Schweinf., T. spelta L., and T. kiharae Dorof. et Migusch. These HMW-GSs are of interest for enriching the wheat gene pool. HMW-GSs of related species were found in 10 out of 19 introgressive lines. A five-year observation period revealed that wheat relatives on average significantly exceeded common wheat cultivars in gluten quality, and introgressive lines did not differ significantly from the parental genotypes. Lines with high rheological properties of gluten had, as a rule, HMW-GSs of related species in their composition.
Environmental adaptability of spring durum wheat (Triticum durum Desf.) cultivars developed in Saratov
Authors: Gaponov S. N. , Shutareva G. I. , Tsetva N. M. , Tsetva I. S. , Milovanov I. V. , Burmistrov N. A. , Zhiganova E. S. , Solovova N. S.
Published: May 2024

Background. The spreading of drought-resistant spring durum wheat cultivars with high grain quality developed by Saratov breeders to the eastern regions of Russia is dictated by climate change: higher air temperatures, precipitation deficit during the growing season, and summer droughts.

Materials and methods. The material for research included seven spring durum wheat cultivars developed at the Federal Center of Agriculture Research (FCAR) of the South-East Region in Saratov: ‘Valentina’, ‘Nik’, ‘Yelizavetinskaya’, ‘Nikolasha’, ‘Luch 25’, ‘Pamyati Vasilchuka’, and ‘Tamara’. The cultivars and their yields in 2012–2022 were evaluated to calculate the coefficients of environmental plasticity and stability according to the methods by S. A. Eberhart and B. A. Russell, as interpreted by V. A. Zykin. Grain quality indicators were measured on the devices: Infratec 1241 for protein, Glutomatic for the index of gluten (IG), and Spekol 10 for the yellowness index (b%).

Results. The adaptability of spring durum wheat cultivars bred in Saratov was confirmed by the coefficients of environmental plasticity and stability. According to the results of the study, cvs. ‘Nik’, ‘Nikolasha’, ‘Luch 25’ and ‘Pamyati Vasilchuka’ with plasticity coefficients (bi) > 1 were highly responsive to the conditions of cultivation and production of high-quality grain.

Conclusion. The data obtained on grain productivity and high quality make it possible to recommend drought-resistant cultivars released by the FCAR of the South-East Region for use in various regions of Russia.
Androgenesis and gynogenesis in tomato (Solanum lycopersicum L.) in vitro
Authors: Shergina A. A. , Kurina A. B.
Published: May 2024

Tomato (Solanum lycopersicum L.) is one of the most consumed vegetable crops worldwide. Tomato fruits are rich in vitamins, minerals, and pigments, including lycopene. The high demand and the need to enhance tomato production call for new improved cultivars and F1hybrids.

Biotechnological methods reduce the time for source material development and the labor intensity of breeding efforts. Obtaining doubled haploid plants makes it possible to fix and analyze new gene combinations faster than with conventional breeding techniques, and produce homozygous genotypes. Tomato is highly unsusceptible to haploid induction, which has been continuously studied for more than 40 years and is still of special interest. The main methods for producing haploids are based on androgenesis and gynogenesis. Androgenesis is the production of haploids from the cells of the male gametophyte, and gynogenesis from the cells of the female gametophyte.

The objective was to review the research on the induction of tomato haploids based on androgenesis and gynogenesis. No standardized, efficient or reproducible protocols are currently available to produce doubled haploids of tomato. It is necessary to determine the incubation conditions, physicochemical environments, dependence of the genotypein vitro, physiological state of the donor plant, and development of the anther, which affect the reproducibility of protocols to achieve haploid induction. Anther culture for obtaining haploid tomato plants has not yielded successful results, and the studies on microspore culture were too few, so it is difficult to understand the effectiveness of this technique. The method of gynogenesis is poorly investigated, but the culture of unfertilized ovules can become a successful way to obtain tomato haploids, with more research on this subject.
Valentin I. Burenin. The entire life was dedicated to science
Authors: Sokolova D. V. , Piskunova T. M.
Published: May 2024

The name of Prof. Valentin I. Burenin, Doctor of Agricultural Sciences, is widely known both in Russia and abroad. He worked at VIR all his life, giving himself up to science. Valentin Burenin made a significant contribution to the development of Vavilov’s ideas concerning mobilization and utilization of plant resources. His scientific research priorities were the collecting and studying of beet genetic resources, and their utilization in breeding practice.
Влияние 2-этил-6-метилпиридинол-3-ил-тиооктаноата и его неэтерифицированных компонентов на поведение крыс в «приподнятом крестообразном лабиринте»
Authors: Волчегорский Илья Анатольевич , Синицкий Антон Иванович , Гробовой Сергей Иванович , Мирошниченко Ирина Юрьевна , Рассохина Любовь Михайловна , Михайлов Родион Романович
Published: May 2024

Изучено влияние тиоктовой кислоты (ТК), солянокислого 2-этил-6-метил-3-оксипиридина (эмоксипина) и их сложноэфирного деривата (2-этил-6-метилпиридинола-3-ил-тиооктаноата; тиоксипина) на поведение крыс в «приподнятом крестообразном лабиринте» (ПКЛ). Установлено, что трехкратное внутрибрюшинное введение ТК, эмоксипина и их эквимолярной смеси в разовых дозах 36,25, 72,5 и 145 мкмоль/кг усиливает отдельные проявления тревожного поведения в ПКЛ, но не вызывает развернутого анксиогенного эффекта. Подобные проанксиогенные эффекты наблюдаются при введении ТК в дозе 36,25 мкмоль/кг и эмоксипина в дозах 72,5 и 145 мкмоль/кг. Эквимолярная смесь неэтерифицированных компонентов тиоксипина оказывает проанксиогенное действие в дозах 36,25 и 72,5 мкмоль/кг. Объединение ТК и 2-этил-6-метил-3-оксипиридина в структуре сложного эфира потенцирует их проанксиогенную активность, что проявляется развернутым анксиогенным действием тиоксипина при трехкратном введении в дозе 145 мкмоль/кг.
Синтез сложных эфиров бензойной кислоты и их антимикробная активность
Authors: Гроза Н. В. , Яркова Татьяна Александровна , Гесслер Н. Н. , Розумий А. В.
Published: May 2024

Ацилированием хлорангидридом бензойной кислоты природных гидроксилсодержащих соединений 1-октанола и тимола, а также 4-бромтимола получены сложные эфиры (тимолбензоат и 4-бромтимолбензоат впервые), обладающие выраженной антимикробной и противогрибковой активностью. Экспериментально противомикробная активность синтезированных соединений определялась на 3 штаммах бактерий сенной палочки (Bacillus subtilis 10986, 4419 и Bacillus licheniformis 537) и дрожжевых грибах Yarrowia lipolytica W29. При испытании антибактериальной активности синтезированных соединений в качестве препарата сравнения был выбран хлорамфеникол. При микостатических испытаниях в качестве препарата сравнения применялся клотримазол. Антимикробные и противогрибковые испытания синтезированных соединений показали положительный результат, что открывает возможные перспективы дальнейшего исследования этих соединений в качестве противогрибковых и антибактериальных препаратов, лишенных токсичности, присущей бензойной кислоте.
Современные подходы к математическому моделированию процесса прямого прессования таблеток
Authors: Маркеев Владимир Борисович , Блынская Евгения Викторовна , Тишков Сергей Валерьевич , Алексеев Константин Викторович , Алексеев Виктор Константинович
Published: May 2024

В современных исследованиях процесса прессования для оценки механических свойств таблеток используются математические модели, наиболее применяемыми из которых являются уравнения Хеккеля и Кавакиты. Эти классические модели не учитывают все параллельно происходящие при межчастичном взаимодействии процессы, что делает перспективным разработку новых подходов к моделированию процесса таблетирования. К настоящему времени разработано достаточно большое количество моделей прямого прессования, а выбор оптимального уравнения для каждого конкретного случая остается нетривиальной задачей. В статье произведен анализ используемых в настоящее время математических описаний процесса прямого прессования.
Влияние современных антидиабетических лекарственных средств на метаболические и функциональные нарушения у больных сахарным диабетом 2 типа
Authors: Дзугкоев Сергей Гаврилович , Дзугкоева Фира Соломоновна , Хубулова Анна Елизбаровна , Маргиева Ольга Ивановна
Published: May 2024

Изучены особенности метаболических и функциональных нарушений при диабетической нефропатии у больных сахарным диабетом 2 типа и оптимизация стандартного лечения и профилактики с использованием современных антидиабетических лекарственных средств. Под наблюдением находились 45 больных сахарным диабетом 2 типа с длительностью болезни 10 – 15 лет, в возрасте 60 – 75 лет. Контрольную группу составили 15 здоровых лиц без сахарного диабета и проявлений других патологических процессов. Стандартная терапия включала метформин, а комплексная — дапаглифлозин, вилдаглиптин, эналаприл и аторвастатин. У всех больных до лечения отмечали повышение уровня HbA1c, концентрации малонового диальдегида в эритроцитах на 91 %, снижение активности супероксиддисмутазы на 30 %, уменьшение уровня NOx на 40,2 %, по сравнению с показателями пациентов контрольной группы. Присутствующая дисфункция эндотелия сосудов сопровождалась нарушением функционального состояния почек: снижением скорости канальцевой фильтрации, реабсорбции воды и Na+, повышением экскреции Na+, белка и полиурией. Применение метформина сопровождалось положительными, но недостаточно эффективными результатами: снижением концентрации малонового диальдегида на 21,8 % и повышением содержания NOx на 16,8 %, по сравнению с исходными значениями (p ≤ 0,05). Применение комбинации антидиабетических лекарственных средств обусловило позитивную динамику метаболических показателей: снижение малонового диальдегида на 31 %, повышение NOx на 37,4 %, снижение ЛПНП на 31,5 %. Выявлена положительная динамика функционального резерва почек: скорость клубочковой фильтрации повысилась на 15,6 %, диурез, экскреция Na+ и белка сократились соответственно на 7,36, 12,82 и 45,3 %, по сравнению с показателями пациентов до лечения (p ≤ 0,05). Кроме того, показатели систолического АД снизились на 19,05 %, а диастолического АД — на 14,9 %.
Антидепрессивноподобная активность ноопепта и его влияние на mGluII-рецепторы коры головного мозга мышей BALB/c
Authors: Ковалёв Георгий Иванович , Абдуллина Алия Анвяровна , Васильева Екатерина Валерьевна , Колясникова Ксения Николаевна
Published: May 2024

Изучено влияние ноопепта (1, 5, 10 мг/кг, в течение 2 недель) при интраназальном и пероральном введении на поведение и на mGluII-рецепторы коры головного мозга мышей BALB/c. Впервые было обнаружено наличие у ноопепта антидепрессивноподобной активности — в тесте Порсолта интраназальное введение ноопепта (1 мг/кг/день) мышам BALB/c приводило к снижению периода иммобилизации на 24 %, по сравнению с контролем. Пероральный путь введения пептида обеспечивал более выраженный антидепрессивноподобный эффект — продолжительность иммобилизации уменьшалась на 39 % (10 мг/кг/день). В рецепторных исследованиях интраназальное двухнедельное введение ноопепта в дозе 1 мг/кг/день сопровождалось возрастанием плотности mGluII-рецепторов в коре головного мозга на 23 %, однако в группе животных, получавших ноопепт внутрь (10 мг/кг/день), данный параметр не отличался от контроля. Выявленная разница в величинах плотности рецепторов (Bmax) в головном мозге животных двух групп, демонстрирующих антидепрессивноподобное поведение, указывает на то, что mGluII-рецепторы не задействованы в механизме данного действия ноопепта, хотя могут участвовать в реализации других видов психофармакологической активности.
Оценка нейропротекторной активности пептидного миметика гетерорецептора EPOR/CD131 при моделировании нейродегенеративных процессов
Authors: Степенко Юлия Владимировна , Покровская Татьяна Григорьевна , Корокин Михаил Викторович , Покровский Михаил Владимирович , Зеленцова Александра Сергеевна , Кузубова Елена Валерьевна , Пересыпкина Анна Александровна , Патраханов Евгений Александрович , Юрова Татьяна Юрьевна , Попов Александр Андреевич
Published: May 2024

Тау-протеинпатия — группа нейродегенеративных заболеваний, характеризующаяся гиперфосфорилированием тау-белка вследствие посттрансляционных модификаций. Потенциальным фармакологическим веществом, который воздействует на патогенетические каскады гиперфосфорилирования тау-белка, является пептидный миметик гетерорецептора EPOR/CD131 (ARA-290). Показано, что ARA-290 изменяет параметры митохондриального дыхания, вызванные влиянием стрессоров-модуляторов. Для оценки энергетического фенотипа использовали культура нейронов мышей линии P301S, и в условиях окислительного стресса соединение ARA-290 улучшало метаболическую активность, тем самым демонстрируя свои нейропротекторные свойства. При оценке поведенческих реакций в тесте «Открытое поле» экспериментальная группа P301S с фармакологической поддержкой ARA-290 продемонстрировала быструю адаптационную способность, о чем свидетельствовали высокие показатели нахождения животных в центральной зоне арены. Таким образом, улучшение когнитивных функций подтвердилось и в результате тестирования на модели «Распознавание новых объектов», в котором отмечены высокие значения общего расстояния и средней скорости передвижения в арене, а также высокие показатели заинтересованности новым объектом и индексов предпочтения и дискриминации. Со стороны оценки двигательных функций у экспериментальной группы мышей, получавшей соединение ARA-290, обнаружены существенные отличия в более долгом времени удержании равновесия на перевернутой сетке, что свидетельствует о улучшенной координации и локомоции. В свою очередь, полученные статистически достоверные значения отличались у экспериментальной группы от групп сравнения и положительного контроля, что свидетельствует о замедленном прогрессе моторной дисфункции и координации движений у мышей трансгенной линии P301S.
THE ROLE OF THE NOTARY IN SALE AND PURCHASE AGREEMENT FOR MOVABLE PROPERTY (BASED ON DECISION NUMBER 33/PDT.G/2018/PN.BLK)
Authors: Melnia Nur Fitri , Susilowati Suparto
Published: May 2024

Article 15 paragraph (2) letter e of Notary Regulation states that a Notary has the authority to provide legal advice regarding the formation of a legal document. Sale and purchase agreement with an installment system is an anonymous agreement. The object of journal writing is Decision Number 33/Pdt.G/2018/PN.Blk. This research is descriptive analytical using a normative juridical approach, then the data is analyzed using qualitative juridical data analysis. Based on the research, the first result obtained is the authority of a Notary in legal counseling is only regulated in Article 15 paragraph (2) letter e of Notary Regulation and the installment sale and purchase agreement document is an unnamed agreement because there is no specific regulation in the law and the Civil Code in Indonesia, but this agreement still provides legal certainty. The second result is Decision Number 33/Pdt.G/2018/PN.Blk. The defendant has defaulted and obliged to pay the remaining payment. The Plaintiff must hand over to the Defendant 3 (three) documents of ownership of the vehicle being traded after the Defendant's debt is paid off.
ANNOTATION OF JUDGE'S DECISION NO: 99/G/2020/PTUN-JKT ACCORDING TO THE PERSPECTIVE OF ONRECHTMATIGE OVERHEIDSDAAD
Authors: Andrian Yasmine Putri , An'nissa Dwi Febrianti  , Wildan Avie Athoillah
Published: May 2024

Judges and prosecutors are law enforcers in Indonesia and are an inseparable part of the court. Both Judges and Prosecutors in exercising their powers and responsibilities must be carried out carefully without any intervention from any party. The accuracy of Judges and Prosecutors in carrying out their duties is needed to avoid the actions of Onrechtmatige Overheidsdaad which can result in injustice. This research was written with the aim of contributing ideas to society in general regarding the annotation of judge decisions according to the Onrechtmatige Overheidsdaad perspective. Onrechtmatige Overheidsdaad has the substance that government actions that violate the law can lead to liability for losses resulting from these actions. This research technique was carried out by collecting data and then compiling it to answer existing problems.
EFFECTIVENESS OF RESTORATIVE JUSTICE FOR VICTIMS OF NARCOTICS CRIME
Authors: Alifuddin Moj , Talib Hambali , Zainuddin
Published: May 2024

The aim of this research is to analyze the effectiveness of implementing restorative justice for victims of drug-related crimes and the factors influencing the effectiveness of restorative justice for these victims at Polrestabes Makassar. This empirical legal research was conducted at Polrestabes Kota Makassar. The research utilized both primary and secondary data, and data collection techniques involved interviews. The data analysis was performed using qualitative descriptive analysis.
The research findings indicate that the application of Restorative Justice at Polrestabes Makassar is quite effective in terms of the quantity of drug-related cases resolved. The significant factors contributing to the effectiveness of Restorative Justice include adequate psychological and social support, collaboration with relevant institutions, and a legally-based approach.
Perkembangan Teknologi Pengemasan dan Penyimpanan Produk Pangan
Authors: Ropikoh Siti , Widjayanti Widjayanti , Idris Muhammad , Nuh Gifar Muhammad , Fanani Muhammad Zainal
Published: May 2024

Perkembangan penggunaan kemasan produk pangan sudah ada sejak zaman prasejarah. Perbedaan yang signifikan adalah tujuan penggunaan kemasan. Teknologi memiliki peranan penting dalam perkembangan kemasan produk pangan. Tren fungsional kemasan produk pangan saat ini adalah salah satunya ramah lingkungan. Hal ini disebabkan produk pangan memiliki sifat berkelanjutan, sehingga penting untuk mencari solusi ini. Biodegradable packaging bisa menjadi solusi dalam permasalahan ini. Sebab jenis kemasan ini dapat terurai di lingkungan atau bisa disebut juga sebagai kemasan ramah lingkungan. Metode penelitian yang digunakan dalam review jurnal ini adalah pendekatan kualitatif dengan studi literatur. pendekatan kualitatif dipilih karena metode ini dapat memberikan pemahaman yang lebih mendalam dan detail mengenai fenomena yang diteliti. Penulis menggunakan studi literatur sebagai sumber data yang dapat diandalkan dan relevan untuk memperoleh informasi terkait produk pangan lokal. Menurut penelitian Biodegradable Packaging dapat menjadi solusi dalam permasalah “kemasan ramah lingkungan”, namun tetap harus dengan bergantung pada campuran bahan bio-nano komposit dan polimer, yang akan meningkatkan kinerjanya.