bluuebunny/crossref_metadata_2025 huggingface dataset:
Blood mononuclear cell molecular landscape associated with tumor progression in triple-negative breast cancer
Authors: Patysheva M. R. , Frolova A. A. , Bragina O. D. , Fedorov A. A. , Vostrikova M. A. , Garbukov E. Yu. , Iamshchikov P. S. , Vashisth M. , Cherdyntseva N. V. , Gerashchenko T. S.
Published: November 2023

Introduction. triple negative breast cancer is an aggressive clinical phenotype characterized by poor prognosis. immune system plays an important role in the development, treatment response, and progression of solid tumor. The search for immune-related markers associated with the prediction of treatment efficacy and disease prognosis, and based on the use of high-resolution molecular techniques, is a promising area of research, the results of which can be translated into clinical practice. Case description. The molecular profile of blood mononuclear cells in a 48-year-old female patient with histologically proven triple negative breast cancer (estrogen Receptor – 0; progesteron Receptor – 0; Her2/neu – 0; gata-3 – 0, androgen Receptor – 0 and Ki67 – 70 %) was described. The patient did not response to neoadjuvant chemotherapy with 4 cycles of paclitaxel + carboplatin followed by 2 cycles of adriamycin + cyclophosphamide. The patient underwent surgery. disease progression (pelvic bone metastases) occurred 2 months after surgery. The features of blood lymphocytes and monocytes associated with a lack of response to neoadjuvant chemotherapy and disease progression were described.

Conclusion. This clinical case demonstrates that sequencing of peripheral blood mononuclear cells can be used as a method for identifying predictive markers of therapy efficacy and developing personalized treatments for patients with triple negative breast cancer.
Endoscopic autofluorescence imaging in the diagnosis of premalignant lesions and laryngeal/hypopharyngeal cancer
Authors: Taraskina I. О. , Cheremisina О. V. , Pankova О. V. , Mukhamedov M. R. , Ananina О. A.
Published: November 2023

The purposeof the study was to assess the diagnostic value of endoscopic autofluorescence imaging (AFI) in patients with premalignant lesions and primary laryngeal/hypopharyngeal cancer.

Material and Methods. The diagnostic value of AFI was assessed in 53 patients with chronic hyperplastic laryngeal/hypopharyngeal lesions and 48 patients with laryngeal/hypopharyngeal cancer.

Results. The inclusion of video laryngoscopy with AFI in the algorithm for examining patients with chronic diseases of the upper respiratory tract made it possible to significantly improve the diagnostic efficacy of endoscopic examination in patients with premalignant lesions (high grade dysplasia) of the laryngeal mucosa. Video laryngoscopy with AFI was found to achieve higher sensitivity, specificity and accuracy rates than white light video laryngoscopy (87.5, 96.9 and 92.5 vs 50.0, 96.0 and 71.7 %, respectively, p<0.05). The video laryngoscopy with AFI allowed identification of not only pathological changes in the laryngeal and hypopharyngeal mucosa but also their malignant potential, as well as identification of areas for targeted biopsy. In 9 (18.8 %) laryngeal cancer patients, the standard white light video laryngoscopy demonstrated difficulties in the differential diagnosis of laryngeal cancer (n=4) and in assessing the extent of laryngeal cancer (n=5). In 3 out of 4 diagnostically difficult cases, video laryngoscopy with AFI made it possible to confirm the diagnosis of laryngeal cancer and in 5 cases to accurately determine the extent of hypopharyngeal cancer.

Conclusion.The addition of standard videolaryngoscopy with a hightech technique of autofluorescence endoscopy makes it possible to accurately diagnose premalignant and malignant lesions of the larynx and hypopharynx.
Measurement of calcitonin and cea in the needle washout fluid from thyroid nodule for the diagnosis of medullary thyroid carcinoma
Authors: Severskaya N. V. , Chebotareva I. V. , Zhelonkina N. V. , Belyakova A. S. , Isaev P. A. , Polkin V. V. , Ilyin A. A. , Ivanov S. A. , Kaprin A. D.
Published: November 2023

Background. medullary thyroid carcinoma (mtc) produces serum markers including calcitonin (ct) and carcinoembryonic antigen (cea). The measurement of ct in fine-needle aspirate washout fluid (FNA-CT) improves the cytological diagnosis of mtc. However, no data are available about cut-off values for FNA-CT using currently immunoassay. The measurement of cea in the needle washout fluid (FNa-cea) in mtc has not been studied.

Objective: to assess the diagnostic value and propose cut-off values for FNA-CT and FNacea in the thyroid nodule to diagnose mtc.

Material and Methods. We conducted a retrospective analysis of 164 samples of fine-needle aspirate washout fluid collected from 92 patients with thyroid nodules, who underwent FNa followed by cytological examination and measurement of FNA-CT. seventeen cases with mtc and 41 with non-mtc nodules were histologically verified. one hundred and six nodules identified as non-mtc by cytology were not operated on. FNa-cea was additionally studied in 29 samples. The cut-off value was determined by Roc analysis.

Results. The FNA-CT level was >2000 pg/ml in all mtc nodules, except for one, in which the FNA-CT level was 638 pg/ml. In non-mtc nodules, the FNA-CT levels were <10 pg/ml and <100 pg/ml in 81 % and 90 %, respectively, however, it was >500 pg/ml in 5 %, and >1000 pg/ml in 2 %. At a cut-off value of 590 pg/ml, the sensitivity and specificity of FNA-CT were 100 % and 96 %, and at a cut-off of 1721 pg/ml, the corresponding values were 94 % and 99 %. The false positive FNA-CT values were 3.7 % and 1.2 % at the cut-off values of 590 pg/ml and 1721 pg/ml, respectively. The median levels of FNa-cea in mtc and non-mtc nodules were 59.3 ng/ml and 1.5 ng/ml, respectively. At a cut-off value of 7.5 ng/ml, the sensitivity of FNa-cea was 86 % and specificity was 100 %. Additional measurement of FNa-cea prevented all false-positive results of FNA-CT, but did not detect 2 mtcs with low FNa-cea levels (false-negative rate of 6.9 %). Among samples with FNA-CT value of >590 pg/ml and negative cytology (n=9), FNa-cea differentiated mtc with 100 % sensitivity and specificity.

Conclusion. The maximum sensitivity of FNA-CT in the thyroid nodule was at a cut-off value of 590 pg/ml (100 %), the maximum specificity was at a cut-off value of 1721 pg/ml (99 %). Risk of false positive result is the major challenge of FNA-CT. to reduce false-positive results, we recommend to measure FNa-cea in the nodules with negative cytology and high level of FNA-CT. At a cut-off value of 7.5 ng/ml, FNa-cea allows the false-positive FNA-CT to be excluded.
Specific features of endocrine regulation of plastic processes in premature infants and children small for gestational age
Authors: Shaydullina M. R. , Mansurova A. T.
Published: November 2023

Low-birthweight and preterm infants have high risk of obesity and obesity-related diseases in the future. This review article identifies risk factors and endocrine biomarkers with greatest predictive value to the metabolic diseases development. Low concentrations of IGF-1 in low-birthweight children are associated with adipogenesis. Low leptin levels may be considered as a biomarker of catch-up growth. Long term programming effects of in utero exposure to leptin extend beyond infancy into early childhood. Adiponectin levels are positively correlated with obesity in early life, but not at ages older than three years. Rapid postnatal growth rate is associated with metabolic syndrome. Conclusion. Specific features of endocrine regulation of growth and dynamics of plastic processes in premature infants and SGA children are associated with excessive accumulation of adipose tissue, which can function as a mechanism for metabolic programming of distant endocrine and cardiometabolic disorders.
Fecal calprotectin as a marker of inflammatory bowel diseases
Authors: Kamalova A. A. , Garina G. A. , Valeeva I. Kh. , Gaifutdinova A. R.
Published: November 2023

Calprotectin is a calcium- and zinc-binding protein belonging to the S100 protein family. This protein is found mainly in the cytoplasm of neutrophils, and, to a lesser extent, in monocytes and macrophages, which can be found in any human organs, but mainly in blood, cerebrospinal fluid, feces, saliva, and synovial fluid. Calprotectin is an effective tool forthe differential diagnosis of inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS). There is a connection of fecal calprotectin (FC) with the endoscopic activity of IBD, however, the available literature shows significant differences in the sensitivity and specificity of FC for predicting the endoscopic activity of the disease. In addition, FC can be considered as a predictor of histological mucosal healing and as a marker for assessing the response to treatment, including surgical, but there is still no consensus on the threshold value of a biomarker for these purposes. Conflicting data are presented in reports on FC as a predictor of IBD recurrence. FC seems to be effective for detecting relapse, however, there is no specific threshold value, therefore, the marker cannot completely replace endoscopic examination methods. In addition, there is intraindividual variability in the concentration of FC in patients, depending on age, type of feeding in the first year of life, taking medications, which significantly complicates the interpretation of the results.
Transient myelodysplastic syndrome in a newborn
Authors: Gabitova N. Kh. , Cherezova I. N. , Kazakova F. M. , Osipova I. V.
Published: November 2023

The article presents a unique case of a transient myelodysplastic syndrome characteristic of children with trisomy 21. This condition has non-specific clinical manifestations and a specific hematological picture similar to those of acute leukemia. The uniqueness of transient myelodysplastic syndrome lies in the spontaneous resolution within a few weeks or months after birth and/or the development of acute myeloid leukemia after spontaneous regression in the first 4–5 years of life. A prerequisite for the development of myelodysplastic syndrome is the presence of a blast clone of trisomy of the 21st chromosome and a mutation in the GATA1 gene in the cells.
Dystrophic bullous epidermolysis in a newborn
Authors: Babintseva A. A. , Sadykova D. I. , Zvegintseva К. О.
Published: November 2023

Congenital bullous epidermolysis is a severe hereditary disease, the main manifestation of which is bubbles that occur after minor mechanical action on the skin and mucous membranes due to congenital violation of the coding of dermo-epidermal proteins. The difficulty in making a diagnosis of congenital bullous epidermolysis is associated with the rarity of pathology and a small number of scientific publications.
Acute kidney injury as the onset of cystic fibrosis in a child of 1 year of age
Authors: Safina A. I. , Mikhailova T. V. , Zakirov I. I. , Suleimanova I. M.
Published: November 2023

Early diagnosis of the cystic fibrosis remains an urgent problem, despite ongoing nationwide neonatal screening. The uniqueness of the presented clinical case lies in the atypical onset of cystic fibrosis in a young child with clinical manifestations of acute kidney injury. The suddenly developed severe general condition in a child was due to manifestations of acute renal injury of the third stage (severe lethargy, anuria for 14 hours, an increase in blood creatinine to 121 µmol/L, a decrease in glomerular filtration rate to 17.4 mL/min), decompensated metabolic alkalosis with hypokalemia, hyponatremia, hypocalcemia (pH 7.6, K+ 2.6 mmol/L, Na+ 118 mmol/L, Ca2+ 0.96 mmol/L, HCO3 – 35.5 mmol/L). The observed disturbances in acid-base status and electrolyte metabolism were manifestations of the pseudo-Bartter syndrome. For the prevention of acute kidney injury in a patient with cystic fibrosis, timely electrolyte and fluid management is important to prevent the development of pseudo-Bartter’s syndrome, exsicosis and hypovolemia.
Thermal performance investigation of porous fins with convection and radiation under the influence of magnetic field using optimal homotopy asymptotic method
Authors: Sobamowo M. G. , Berrehal H. , Ajayi A. B. , Onanuga O. K. , Fawumi R. O.
Published: November 2023

A study on enhancement of heat transfer in thermal systems by convective-radiative porous fin with temperature-invariant thermal conductivity is presented in this paper using optimal homotopy asymptotic method. The efficacy of the method is displayed through the verification of the results with the previous studies. Also, significance of various parameters of the nonlinear model on the heat transfer enhancement of thermal systems using the solutions presented by the method are discussed. The graphical representation of the thermal behaviour of the extended surfaces is presented for pictorial discussion. The results illustrate that the augmentations of the conductive-radiative, conductive-convective, porosity and magnetic field cause the extended surface temperature to reduce as a result of increased rate of heat flow via the passive device. The graphical illustrations show that the efficiency and effectiveness of the fin is high at low values of the radiative-conductive, convective-conductive, porosity and magnetic field parameters. This study will assist in proper thermal analysis of fins for effective thermal managements of engineering systems.
Differential thermal analysis of moisture binding in zephyr with different contents of glucose syrup
Authors: Plotnikova Inessa , Magomedov Gazibeg , Kazartsev Dmitry , Magomedov Magomed , Polansky Konstantin , Plotnikov Viktor
Published: November 2023

When formulating a product, it is just as important to measure changes in free and bound moisture as it is to analyze quality indicators. Zephyr, a Russian whipped dessert, made with sugar dries quickly during storage, gradually losing its moisture. Its crystalline sugar crust thickens and its entire mass saccharifies, resulting in higher firmness and poor appearance. In this study, we aimed to determine the effect of high-conversion glucose syrup on the amount of moisture and its binding forms in zephyr after storage.

We studied four samples of pectin-based zephyr with different carbohydrate profiles after three months of storage. Differential scanning calorimetry, thermogravimetry, and non-isothermal kinetics were applied to assess moisture contents and forms of binding in zephyr.

Thermograms with thermoanalytical curves were used to analyze the thermolysis of zephyr samples with different contents of glucose syrup in the temperature range from 20 to 300°C. We also studied the endothermic effects at various stages of thermolysis and measured free and bound moisture in the samples. Four stages of their dehydration were identified on the basis of graphical dependences between weight changes and heating temperatures.

The control zephyr sample contained more capillary and polymolecular bound moisture, while the experimental samples in which sugar and confectioner’s syrup were partially or completely replaced with high-conversion glucose syrup had more polymolecular and monomolecular bound moisture. The use of high-conversion glucose syrup instead of sugar and confectioner’s syrup reduced the amount of free moisture and therefore increased the amount of bound moisture, keeping zephyr fresh throughout its shelf life.
Plant proteases and anti-bacterial substances in Allium sativum L. varieties
Authors: Budianto Budianto , Arifin Muh Jaenal , Naryani Naryani , Sukmawati Endah , Suwaji Suwaji , Wibowo Tri Handoko Moedji , Luviana Syahilla Vanda , Putri Lia Dekryt Vergiana
Published: November 2023

Allium sativum L. protease still remains largely understudied although new varieties of garlic appear quite often, e.g., lanang garlic. This study tested the antibacterial effect of garlic and the effectiveness of various A. sativum proteases as meat tenderizers.

The research involved powder extracts of four varieties of A. sativum: kating, lanang, black garlic, and sin-chung. The degradation kinetics was defined based on the Lineweaver-Burk equation. The degradation zones were measured using sodium dodecyl sulphate poly acrylamide gel electrophoresis (SDS-PAGE). Scan electron microscopy served to test the changes in meat connective tissue.

Lanang demonstrated the largest inhibition zones against Escherichia coli (9.75 ± 0.15 mm) and Staphylococcus aureus (1.04 mm). Sin-chung protease degraded beef protein with the highest Vmax of 0.1818 μg/μL/min at 10–22 KDa (small peptide, troponin C, and troponin I), 25–40 KDa (myosin light chain, troponin T, α and β tropomyosin, actin), and 100–140 KDa (protein C). The same garlic variety degraded mutton meat protein at 10–17 KDa (small peptide) and 25–40 KDa (myosin light chain, troponin T, α and β tropomyosin, actin) with Vmax of 0.1135 μg/μL/min.

All four A. sativum proteases proved to be quite effective meat tenderizers.
SNP-based genetic signatures revealed breeding effects in indigenous Livni compared with Landrace and Large White breeds
Authors: Chernukha Irina , Kotenkova Elena , Fedulova Liliya
Published: November 2023

Livni is one of the Russian local pig breeds. We previously reported that this breed was more distinct from Duroc breed than from Landrace and the Large White breeds, which participated in the Livni breed creation. The aim of the study was to determine the SNP-based genetic signatures in fat-type Livni breed shared with commercial Landrace and the Large White breeds, and ones that are affected by putative selection.
The genome-wide SNP genotyping was carried out using the Porcine GGP HD BeadChip, which contains ~ 80 000 SNPs.
Obtained breed relationship and admixture results indicated the insignificant participation of the Landrace and the Large White breeds in the formation of the modern allelofund of Livni pigs. 238 candidate genes were found in the genomic regions with selection signatures, 182 genes with described functions were identified. In the Livni and Landrace breeds, 35 common genes were detected which formed one cluster with enrichment coefficient = 4.94 and predominant HOXD genes. In the Livni and Large White breeds, the largest amounts of common genes were detected (62 in average), which formed two clusters. Cluster 1, with enrichment coefficient = 2.11, was characterized with genes involved in glucose metabolism. Cluster 2, with enrichment coefficient = 1.60, demonstrated helicase genes. Annotated clusters were not determined for the Livni breed. However, 50 candidate genes were specific to Livni pigs and associated with various growth, carcass and reproductive traits, essential for thermoregulation.
Results revealed common SNP-based genetic signatures and breeding effects in indigenous Livni compared with Landrace and Large White breeds.
Rapidly Growing Ovarian Granulosa Cell Tumor Following Complete Debulking for Suspected Ovarian Cancer with Histopathology Result of Benign Ovarian Cyst
Authors: Muhammad Syamel , Antonius Puja Agung , Oktavian Rizki , Savannah Aisha
Published: November 2023

Ovarian granulosa cell tumor (GCT) is a rare low-grade malignancy condition. One type of GCT is adult GCT (AGCT), which has the tendency for late recurrence. AGCT is clinically palpable and focally cystic and solid. In this case report, a condition of recurrent ovarian cancer after laparotomy debulking surgery was reported. A 57-year-old woman, who was diagnosed with AGCT, had a history of laparotomy debulking three months prior and complained of abdominal pain and enlargement, along with significant weight loss. Ultrasound examination revealed a solid cyst, raising suspicion of recurrent ovarian cancer. Laboratory results indicated elevated CA-125 levels. Histopathology results confirmed metastasis of AGCT, after the second laparotomy debulking was done. Recurrence of GCT is uncommon within three months of debulking. In this rare condition, we suggested a laparotomy debulking and adjuvant chemotherapy as a treatment. Effectiveness of treatment of recurrent disease is an independent risk factor to reduce the risk of another relapse and increase the survival rate.Keywords: granulosa cell tumor, ovarian cancer, debulking
influence of work motivation and leadership style on employee performance in oil and gas companies in Palembang
Authors: Indahsari Siti Rachmi , Zunaidah Zunaidah , Widiyanti Marlina , Yusuf Muhammad
Published: November 2023

This research aims to determine the influence of work motivation and leadership style on employee performance in oil and gas companies in Palembang. The population in this study consists of all production function employees in oil and gas companies in Palembang in the years 2022-2023, totaling 428 individuals. Based on calculations using the Slovin formula, the sample size for respondents in this study is 114 employees in oil and gas companies in Palembang in the years 2022-2023. The results of multiple linear regression analysis show that work motivation and leadership style positively and significantly impact employee performance. Regarding work motivation, it is recommended to make changes in specific work units to maintain good relationships among employees and superiors. Regarding leadership style, there should be special attention from the company management to the leadership role toward employees. For employees to be appointed leaders, stakeholder training is necessary to become leaders who can support and make fair decisions for all employees.
E-Gram Panchayats: Enhancing Accountability and Transparency in Rural Administration
Authors: Thorat Mrs. Madhuri
Published: November 2023

Abstract: The "e-Gram Panchayat" application is a transformative digital platform designed to enhance the efficiency, transparency, and accessibility of rural governance in India. This application leverages Information Technology (IT) to bridge the digital divide and empower Gram Panchayats, the local self-governing bodies, to better serve their constituents. The project aims to bring government services, land records, social welfare schemes, and administrative processes to the fingertips of citizens in rural areas.Key features of the e-Gram Panchayat application include a user-friendly interface accessible via web and mobile, comprehensive data management systems, robust security measures, and integration with other government databases. It also includes modules for citizen registration, service delivery, document management, GIS mapping, feedback mechanisms, and capacity building.
A Review on Approaches for Enzyme Immobilization
Authors: Kelkar Radhika , Patil Dr Pallavi
Published: November 2023

Abstract: Enzyme The enzymes are widely studied and explored area due to its abundant potential to cater wide application range which makes researchers to study more of this area. The high catalytic activity enabling ease in reactions formation of multiple products and byproducts or breakage of complex substances makes it an unavoidable option. However the cost of pure enzyme increases the economic burden on the operations obstructing its full fledged use. This leads to making enzyme restrict or immobilize within any inert matrix which can improve the reusability and also improve the tolerance against pH and temperature that can improve the activity of enzyme. Many different enzyme immobilization approaches are present in following article we have discussed some of the used approaches.
Advancing Melanoma Diagnosis: A Computer-Aided Diagnostic Approach for Enhanced Precision
Authors: Bhosale Yash , Mahajan Nikhil , Jadhav Ayush , Govilkar Prathamesh , Mane Rushikesh
Published: November 2023

Abstract: Melanoma, a dangerous type of skin cancer, is now the ninth most common cancer. Detecting it early is crucial for easier treatment. Dermoscopy, a common method that magnifies skin lesions for examination, relies on the skill of trained professionals. This limits its use to those with extensive training. To overcome this, our research suggests using a ComputerAided Diagnostic (CAD) system. This system has a user-friendly interface, making it accessible for dermatologists with limited training. Unlike traditional methods, our study shows that CAD not only supports skilled professionals but also provides a reliable second opinion in identifying melanoma. This research aims to improve the accuracy of melanoma diagnosis, making it more accessible and precise for better patient outcomes
CHOROIDAL OSTEOMA: REVIEW OF LITERATURE AND FIRST CASE FROM YEMEN
Authors: Al-Shamahi Essam Yahiya , Al-Shamahi Nashwan Yahya A , Al-Shamahi Emad Hassan , Al-Shamahy Hassan Abdulwahab
Published: November 2023

Juxtapapillary choroidal tumors called choroidal osteomas are benign and do not require medical attention. They predominantly occur in young females (median age, 20 years).  Ophthalmoscopy and fluorescein angiography can disclose indicative ocular signs, but computed tomography (CT), echography, and plain radiography are particularly crucial for making the right diagnosis. These lesions may be clinically misdiagnosed as a number of dystrophic lesions, as metastatic carcinoma, atypical malignant choroidal melanoma, metastatic carcinoma, leukemic or lymphoma infiltration, choroidal macular scarring, choroidal hemangiomas, or organized subretinal hemorrhage. As therapeutic methods, radiation and enucleation, it is crucial to rule out malignant melanoma from the differential diagnosis. According to an assessment of the literature, all reported instances with CT scans exhibited calcific densities that could be easily seen in the affected eye's posterior pole. The clinical, radiologic, and pathologic findings in our patient are all typical. We emphasize the importance of CT in assessing choroidal osteoma as well as the uniqueness of CT results.
                       
Peer Review History:
Received: 11 August 2023; Revised: 14 September; Accepted: 28 October, Available online: 15 November 2023
Academic Editor: Dr. Rola Jadallah, Arab American University, Palestine, rola@aauj.edu
Received file:                             Reviewer's Comments:
Average Peer review marks at initial stage: 6.0/10
Average Peer review marks at publication stage: 7.5/10
Reviewers:
Prof. Gorkem Dulger, Duzce University, Turkey, gorkemdulger@yandex.com
Dr. Bilge Ahsen KARA, Ankara Gazi Mustafa Kemal Hospital, Turkey, ahsndkyc@gmail.com
EPIDEMIOLOGICAL ASPECT OF POSTOPERATIVE GASTROINTESTINAL NUTRITIONAL DEFICIENCY IN NGAOUNDERE HOSPITALS, ADAMAWA REGION, CAMEROON
Authors: Raoul Sineche Ngunte , Valentine Tsague Marthe , Marcel Nguimbou Richard , Roger Ngadjui Ngodjoum Donald , Archange Modjo Gabriel , Jacqueline Ze Minkande
Published: November 2023

Background and objective: Undernutrition is defined as an insufficient intake of nutritional foods. The aim of this study was to evaluate the epidemiological aspect of postoperative gastrointestinal nutritional deficiency in Ngaoundere Hospitals.
Methods: It was a prospective, cross-sectional study with an analytical focus, over a 5-month period from July to November 2022. Undernutrition was defined by the presence of at least one phenotypic criteria plus one etiological criteria. Logistic regression for multivariate analyses, and the Chi-square test for univariate analyses, were used to identify the determinants of undernutrition. A difference was considered significant if p<0.05.
Results: A total of 134 patients were included in the current study. Males were the most represented, with rates of 82.09%. The average age of patients was 36±17.78. Undernutrition at discharge was observed in 110 patients (82.09%). Endogenous risk factors associated with the occurrence of undernutrition were: Muslim religion, persistent symptoms, emergency surgery modality, nutritional grades, postoperative nausea, and diarrhea (p<0.0001); the protective one was minor surgery (p<0.0001). Exogenous risk factors for undernutrition included failure to meet carbohydrate, protein, and calorie targets on day-3 and at discharge (p<0.0001). Finally, in multivariate analysis, persistent symptoms (p=0.02), minor surgery (p=0.04), presence of diarrhea (p=0.01), and failure to meet caloric targets were independently associated with undernutrition at discharge.
Conclusion: The incidence of post-digestive surgery undernutrition is relatively high in the 2 hospitals in Adamawa, Cameroon. It, therefore, requires early detection and management.
                       
Peer Review History:
Received: 7 September 2023; Revised: 2 October; Accepted: 9 November, Available online: 15 November 2023
Academic Editor: Dr. A.A. Mgbahurike, University of Port Harcourt, Nigeria, amaka_mgbahurike@yahoo.com
Received file:                             Reviewer's Comments:
Average Peer review marks at initial stage: 6.0/10
Average Peer review marks at publication stage: 7.0/10
Reviewers:
Prof. Hassan A.H. Al-Shamahy, Sana'a University, Yemen, shmahe@yemen.net.ye
Dr. Owanaro Peter, Nigeria,  Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmacy, Niger Delta University, Wilberforce Island, Bayelsa State, Nigeria. owonaropeter@gmail.com
ANTIBIOTIC SENSITIVITY OF BACTERIAL BLOODSTREAM INFECTIONS IN THE INTENSIVE CARE UNIT PATIENTS OF UNIVERSITY HOSPITALS IN SANA'A CITY, YEMEN
Authors: Al-Yosaffi Eshtiaq A , Al-Shamahy Hassan Abdulwahab , Othman Arwa Mohammed , Al-Haddad Ahmed Mohammed , Al-Moyed Khaled Abdulkarim
Published: November 2023

Aim: High rates of morbidity and mortality are associated to bacterial bloodstream infections (B-BSI) in many hospitals, especially in the intensive care unit. This study investigated the prevalence of antibiotic- and multidrug-resistant bacteria isolated from blood samples of patients in intensive care units of university hospitals in the city of Sana'a, Yemen.
Subjects and methods: A cross-sectional study was conducted on sepsis patients admitted to intensive care units in four hospitals in Sana'a, Yemen, between January 1 and April 30, 2022. The blood cultures of patients suspected of suffering from sepsis were performed. The potential bacterial pathogens were isolated and identified using standard laboratory methods, and microbial susceptibility testing was performed using the disk diffusion technique.
Results: For all identified bacteria, the average resistance rate to a broad spectrum of antibiotics tested ranged from 22.5% to 98.1%, with cefazoline (98.1%) having the greatest resistance rates, followed by amoxicillin (87.2%) and cefixime (83%). Vancomycin had a resistance rate of 4.8% whereas erythromycin had a resistance rate of 75% for Gram-positive bacteria. For Gram-negative bacteria, the resistance rates to narrow spectrum antibiotics ranged from 2.3% for colistin sulphate to 84.8% for aztreonam. Our isolates' MDR rates for resistance to at least three classes of antibiotics were 52.2% and 8.7%, respectively, for resistance to 10 different classes of broad-spectrum antibiotics and their subclasses.
Conclusion: Gram positive bacteria are highly resistant to erythromycin and penicillin, while gram negative organisms are highly resistant to amoxcillin+clavulanic acid, ciprofloxacin, and all generations of cephalosporins. This study highlights the significance of prompt clinical and bacteriological monitoring among patients in critical care conditions, such as ICU patients, and also illustrates the establishment and rates of Multi Drug Resistance (MDR) pathogens.
                       
Peer Review History:
Received: 27 August 2023; Revised: 13 September; Accepted: 29 October, Available online: 15 November 2023
Academic Editor: Dr. Asia Selman Abdullah, Pharmacy institute, University of Basrah, Iraq, asia_abdullah65@yahoo.com
Received file:                             Reviewer's Comments:
Average Peer review marks at initial stage: 6.0/10
Average Peer review marks at publication stage: 7.5/10
Reviewers:
Dr. Tamer Elhabibi, Suez Canal University, Egypt, tamer_hassan@pharm.suez.edu.eg
Dr. Wadhah Hassan Ali Edrees, Hajja University, Yemen, edress2020@gmail.com
DETERMINATION OF MINERALS IN LAVANDULA STOECHAS L. SUBSP. CARIENSIS (BOISS.) ROZEIRA BY X-RAY FLUORESCENCE SPECTROSCOPY
Authors: Hüsniye Kayalar , Sinem Yılmaz Zehra , Cenk Durmuşkahya , Ümit Toktaş
Published: November 2023

Background and objective: Medicinal herbs are sources of bioactive plant secondary metabolites such as phenolic acids, flavonoids, iridoids, tannins, anthracenes, alkaloids, terpenes. Herbs and herbal extracts are important sources for minerals that can create health effects in human diet. The infusion and decoction prepared from Lavandula stoechas L., subsp. cariensis known as Karabaşotu in Turkey, are used in traditional medicine. The objective of the present work was to comparatively determine the mineral content of dried aerial parts L. stoeachas L. subsp. cariensis and  its water extract which is prepared by 2% infusion. 
Methods: The aerial parts of Lavandula stoechas L., were air-dried and grounded. 2% infusion was prepared by distilled water and water was evaporated until dryness. The water extract and the plant powder were analyzed for heavy metals and trace elements by Spectro-IQ II instrument.
Results: The analyzed samples differed significantly in terms of mineral contents. The powdered  aerial parts of L. stoechas L. subsp. cariensis and its water extract are characterized by high contents of potassium, calcium, sodium, chlorine, phosphorous and magnesium. Iron in powdered plant material (576.6 ppm) was found to be almost ten times higher than the water extract (51.7 ppm). Microelements such as copper (78.8 ppm) and zinc (3169 ppm)  accumulated at higher levels in the water extract of L. stoechas L. subsp. cariensis. 
Conclusion: The mineral content of the water extract and the powdered aerial parts of L. stoechas L. subsp. cariensis are quantitatively determined by X-ray fluorescence spectroscopy for the first time. L. stoechas L. subsp. Cariensis collected from other regions of Turkey will be comparatively analyzed by XRF spectrometry in our further studies.
                       
Peer Review History:
Received: 23 August 2023; Revised: 26 September; Accepted: 30 October, Available online: 15 November 2023
Academic Editor: Dr. Gehan Fawzy Abdel Raoof Kandeel, Pharmacognosy Department, National Research Centre, Dokki, 12622,  Giza, Egypt, gehankandeel9@yahoo.com 
Received file:                             Reviewer's Comments:
Average Peer review marks at initial stage: 6.0/10
Average Peer review marks at publication stage: 7.0/10
Reviewers:
Dr. Sangeetha Arullappan, Universiti Tunku Abdul Rahman, Malaysia, sangeetha@utar.edu.my
Ahmad Najib, Universitas Muslim Indonesia, Makassar, Indonesia, ahmad.najib@umi.ac.id
RADIOGRAPHIC EVALUATION OF OVERHANGING RESTORATIONS AMONG YEMENI PATIENTS USING CONE-BEAM COMPUTED TOMOGRAPHY (CBCT)
Authors: Alsada'a Wahip Ahmed Ali , Al-Hamzi Mohsen Ali , Al-Khawlani Abdulwahab Ismail , Al-Shamahy Hassan Abdulwahab
Published: November 2023

Background and aims: Overhanging restorations which is extension of restorative material beyond the confines of a cavity preparation may lead to various complications and risks, including increased gingival fluid flow and oral inflammation. The study aim is to use cone-beam computed tomography (CBCT) to radiographically assess the incidence of overhanging restorations in Yemeni patients.
Methods: A retrospective comparative study was conducted on 404 randomly selected CBCT images dor ≥ 18 years male and female Yemeni patients referred to private radiology centers in different Yemeni cities (i.e., Sana'a, Ibb, Hodeida, Aden and Hadhramout) during the period from January 2021 to June 2022. The overhang was evaluated regarding arch (upper or lower), side (right or left), tooth location, and tooth type (central incisor (I1), lateral incisor (I2), canine (C), 1st premolar (P1), 2nd premolar (P2), 1st molar (M1), 2nd molar (M2) and 3rd molar (M3). The tooth surface was considered the statistical unit to allow an accurate comparison of periodontal variables for each restored surface. The evaluated surface points of class II restorations were mesial and distal, while those of crown restorations were mesial, distal, buccal, lingual, mesiobuccal, mesiolingual, distobuccal, and distolingual.
Results: The prevalence rate of overhang was 59.8% in class II and 51.5% in crown restorations. Class II restoration overhang had no significant association with arch, side, tooth type, and tooth location; however, it had a significant association with tooth and surface point (p<0.05), indicating that it was more significantly observed in the 2nd premolar (67.5%) than the other teeth as well as in the distal surface than the mesial one (73.1% vs. 26.9%, p<0.05
Conclusion: The prevalence of class II and crown restoration overhang is considered high among Yemeni patients. Overhangs observed on class II restorations are more than those observed on crown restorations. Class II restoration overhangs are more commonly observed on the 2nd premolar as well as the distal surface.
                
Peer Review History:
Received: 8 August 2023; Revised: 19 September; Accepted: 26 October, Available online: 15 November 2023
Academic Editor: Dr. DANIYAN Oluwatoyin Michael, Obafemi Awolowo University, ILE-IFE, Nigeria, toyinpharm@gmail.com
Received file:                             Reviewer's Comments:
Average Peer review marks at initial stage: 6.0/10
Average Peer review marks at publication stage: 8.0/10
Reviewers:
Dr. Tamer Elhabibi, Suez Canal University, Egypt, tamer_hassan@pharm.suez.edu.eg
Dr. Bilge Ahsen KARA, Ankara Gazi Mustafa Kemal Hospital, Turkey, ahsndkyc@gmail.com
ASSESSMENT OF THE PRESENT BACTERIOLOGICAL PROFILE AND ANTIBIOTIC SENSITIVITY PATTERN IN CHRONIC SUPPURATIVE OTITIS MEDIA IN SANA’A, YEMEN
Authors: Al-Khamesy Khaled Saad Abdulrahman , Al-Shamahy Hassan Abdulwahab
Published: November 2023

Background and objectives: The drainage of pus from the ear through a ruptured tympanic membrane that lasts longer than 12 weeks is known as chronic suppurative otitis media (CSOM). The purpose of the study was to ascertain the microbiological profile of middle ear chronic inflammation (CSOM) and the isolates' susceptibility to locally accessible antibiotics.
Subjects and methods: Total 111 ear swab samples from patients with clinically confirmed active CSOM were used in this cross-sectional investigation. Following a standard protocol, ear swabs were cultured to identify microbes. A modified Kirby-Bauer disk diffusion method was used to test antibiotic susceptibility, and the Clinical Laboratory Standards Institute's guidelines were followed to determine the diameter of the zone of inhibition.
Results: During two years, 111 patients with chronic suppurative otitis media were collected from January 2020 to the end of December 2022. Most of the patients were males (63.96%) while females were 36.04%. 36.04% of the total patients were in the ≤10-year group, and 29.7% were in the ≥46-year group while the other age groups were less frequent. Microbial growth was seen in 91.9% of samples, but 7.2% of samples did not. Among the samples with growth, 71.2% were monomicrobial, 12.6% were polymicrobial, and 9% had mixed growth with more than three microorganisms. The most frequently isolated bacteria were Pseudomonas aeruginosa (34.95%) followed by Staphylococcus aureus (14.6%) and Klebsiella spp. (9.8%). The antibiotics most sensitive against P. aeruginosa were cefepime (97.7%), meropenem (95.3%), piperacillin-tazobactam (95.3%), and ciprofloxacin (93%). Staphylococcus aureus showed the highest sensitivity to rifampin (100%) and fusidic acid (88.9%).
Conclusion: In the bacteriological profile of CSOM, P. aeruginosa, S aureus, Klebsiella spp., and Acinetobacter spp. are highly prevalent. The distribution of CSOM varies depending on the age group. The antibiotic susceptibility pattern of the bacterial isolates decreased. It is critical to review antibiotic prescriptions based on susceptibility and to be informed of the current trend in bacteriological profiles.
                       
Peer Review History:
Received: 8 August 2023; Revised: 19 October; Accepted: 2 November, Available online: 15 November 2023
Academic Editor: Dr. Iman Muhammad Higazy, National Research Center, Egypt, imane.higazy@hotmail.com
Received file:                             Reviewer's Comments:
Average Peer review marks at initial stage: 6.0/10
Average Peer review marks at publication stage: 7.0/10
Reviewers:
Dr. Tamer Elhabibi, Suez Canal University, Egypt, tamer_hassan@pharm.suez.edu.eg
Dr. Bilge Ahsen KARA, Ankara Gazi Mustafa Kemal Hospital, Turkey, ahsndkyc@gmail.com
Dr. Wadhah Hassan Ali Edrees, Hajja University, Yemen, edress2020@gmail.com
CONFORMATIONAL STUDY OF MOLECULES IN A BIOLOGICAL ENVIRONMENT, DESIGN OF INHIBITORS OF HUMAN AMINOPEPTIDASE M1 IMPLICATED IN CANCER THERAPY
Authors: Soro Issouf , N’Guessan Hermann , Abou Akoun , N’Guessan Raymond Kre , Megnassan Eugene
Published: November 2023

Objective: A novel subnanomolar anticancer hydroxamic acid containing drug candidates, inhibitors of human M1 aminopeptidase (APN) a recent validated target and has reached the predicted subnanomolar range of inhibitory potency.
Methods: A quantitative structure activity relationships (QSAR) complexation model has been developed from a compounds of 37 hydroxamic acid derivatives (AHD1-37 as training set, TS) to establish a linear correlation between the calculated relative Gibbs free energies (GFE: ΔΔGcom) of APN-AHDx complex formation and the experimental inhibition potency (Kiexp). The predictive power of the QSAR model was then validated first with 9 other AHDs not included in the TS and thereafter with the generation of a 3D-QSAR-PH4 pharmacophore (PH4) model to screen the AHD chemical subspace built as a virtual combinatorial library of more than 58,644 AHD analogs). Finally the best PH4 hits were evaluated with the initial QSAR model for predicted potency (Kipre) and pharmacokinetic profile.
Results: The QSAR model linear correlation equation: pKiexp=-0.1901×∆∆Gcom + 8.2886 , R2=0.94, the subsequent PH4 model linear correlation between experiment and PH4-estimated Ki: pKiexp=1.0006× pKipre + 0.0028, R2=0.79 documents the high predictive power of this approach. Finally the screening of the virtual library of AHD analogs yielded 95 orally bioavailable candidates the best reaching a predicted potency (Kipre) of 50 pM and displaying favorable pharmacokinetic profile.
Conclusion: The combined use of molecular modeling (QSAR) and in silico PH4-based screening of the hypothetical combinatorial library has resulted in proposed and predicted potent anticancer candidates with a suitable pharmacokinetic profile.
                      
Peer Review History:
Received: 3 August 2023; Revised: 12 September; Accepted: 25 October, Available online: 15 November 2023
Academic Editor: Dr. Nuray Arı, Ankara University, Turkiye, ari@ankara.edu.tr
Received file:                             Reviewer's Comments:
Average Peer review marks at initial stage: 7.0/10
Average Peer review marks at publication stage: 9.0/10
Reviewers:
Prof. Hassan A.H. Al-Shamahy, Sana'a University, Yemen, shmahe@yemen.net.ye
Prof. Dr. A. Hakan AKTAŞ, Süleyman Demirel University, Faculty of Science and Art, Department of Chemistry, Isparta-Turkey, hakanaktas@sdu.edu.tr
Genetic analysis of zinc rich landraces for yield, quality and nutritional traits in rice (Oryza sativa L.)
Authors:   Department of Genetics and Plant Breeding, Acharya N G. Ranga Agricultural University, Bapatla-522 101, India, Ratnam T.V. , Kumar B.N.V.S.R.R. ,   Regional Agricultural Research Station, Acharya N G. Ranga Agricultural University, Maruteru-531 22, India, Subba Rao L.V. ,   Department of Genetics and Plant Breeding, Rajendranagar, Hyderabad-500 030, India, Srinivas T. ,   Regional Agricultural Research Station, Acharya N G. Ranga Agricultural University, Maruteru-531 22, India, Kumar A.D.V.S.L.P.A. ,   Department of Entomology, Acharya N G. Ranga Agricultural University, Bapatla-522 101, India, Suneetha Y. ,   Department of Genetics and Plant Breeding, Acharya N G. Ranga Agricultural University, Maruteru-531 22, India
Published: November 2023

Aim: To study genetic variability, correlation, path and Principal Component Analysis (PCA) in a set of 100 zinc rich rice landraces along with four checks. Methodology: The study was carried out at the Regional Agricultural Research Station (RARS), Maruteru, during Rabi season, 2020-2021 in an Augmented Randomized Block Design. Results: Grain yield per plant, grains per panicle, productive tillers m-2 and test weight showed moderate genotypic coefficient of variation (GCV) and phenotypic coefficient of variation (PCV) coupled with high heritability and genetic advance as per cent mean. These traits also had positive and significant association coupled with high positive direct effect on grain yield per plant. They also contributed maximum variance to the total variability indicating the effectiveness of direct phenotypic selection for these traits for improving the grain yield per plant. Further, cluster analysis grouped the zinc rich rice landraces along with checks into three clusters. Cluster II had the highest genotypes (42), while Cluster I had 32 genotypes and Cluster III consisted of 30 zinc rich landraces along with three check varieties. Interpretation: Grains per panicle, productive tillers and test weight were identified as effective selection criteria for the improvement of grain yield towards development of high yielding zinc-rich rice varieties to curtail micronutrient malnutrition in areas with rice as staple food. Key words: Cluster analysis, Landraces, Oryza sativa, Path analysis, PCA, Zinc
The Implementation of Cloud Enterprise Resource Planning by Snell X in Manufacturing Process Strategy: A Case Study of Skincare’s Company
Authors: Mu’min Rizaldi , Haekal Jakfat , Lutfi Muhammad Isa , Kholil Muhammad , Yunus Khairul Nizam Mohd
Published: November 2023

In the midst of the growing awareness of the Indonesian people to use skincare products from various manufacturers, Company X is one of the SMEs involved in it. Skincare products are sensitive products that can have a direct impact on the wearer. The risk in the skincare business is that Company X must ensure that all materials and production processes are carried out safely and according to procedures. Meanwhile, Company X must also pay attention to maximizing existing resources, including time efficiency. Through this problem, Company X decided to implement an ERP system in its manufacturing process. The purpose of this research is to find out how the process takes place on the production side if it is implemented into the ERP system, as well as observe the benefits and challenges that will be faced by Company X. The method used in this research is qualitative with systematic review which will be described descriptively by conducting direct observations. As a result, the manufacturing process runs normally with the use of several new terms in the system, besides that several advantages are found such as cutting time and costs, however, regarding the limitation, this research only mentions time efficiency advantage. Due to the new system, the adaptation of employees and the high cost of maintaining the system will be the challenges for Company X.
Analisis Hambatan Inisiatif Industri 4.0 Pada Rantai Pasokan Industri di Indonesia
Authors: Ariyanti Fransisca Dini , Nasution Januar , Mahardini Karunia Agung
Published: November 2023

Di negara berkembang, khususnya Indonesia, Industri 4.0 relatif masih baru. Karena inisiatif dari Industri 4.0 dapat mengubah cara produk dirancang, diproduksi, dikirim, dan dibuang, dan mempengaruhi seluruh sistem bisnis. Tujuan penelitian ini, adalah untuk meneliti hambatan utama penerapan Industri 4.0 untuk mencapai arah pengelolaan dalam rantai pasokan. Sehingga dapat di susun daftar prioritas atas hambatan utama yang diidentifikasi. Dalam penelitian ini di identifikasi delapan belas hambatan  inisiatif Industri 4.0, selanjutnya diklasifikasikan pada empat kriteria utama yaitu: Organisasi (O), Teknologi (T), Strategi (S), Legal & Etika (L).  Untuk mendapatkan umpan balik dari ahli industry di Indonesia, digunakan survei secara online kepada praktisi industry dan akademisi. Metodenya kombinasi dari EFA, Explanatory Factor Analysis, dan rangking prioritas dengan ANP Analytic Network Process. Hasil prioritas adalah hambatan Organisasi paling penting, diikuti hambatan Teknologi sebagai peringkat kedua, lalu hambatan Strategi sebagai peringkat ketiga, dan hambatan Legal & etika sebagai peringkat terakhir.