bluuebunny/crossref_metadata_2025 huggingface dataset:
Competition of Territories for the Future: Features of Origin and Formation
Authors: Vazhenina I. S. , Vazhenin S. G.
Published: January 2023

The competition of territories is an objective reality, however, some theoretical and methodological issues of its development today and especially in the future still need to be finalized. The article is devoted to the disclosure of socio-economic prerequisites and opportunities for designing the competition of territories for the future in the conditions of the emerging economic space. The authors support and develop the position according to which the competition of territories for the future is largely determined by the construction of the image of the future of territories. The assertion is substantiated that the competition of territories for the future is a struggle for the opportunity to form the future architecture of the socio-economic development of the territory, for achieving future success that goes beyond the established (traditional) ideas about the successful development of regions and municipalities. The main characteristics of the competitive competencies of the territory, as well as territorial individuality, are formulated. The authors consider it necessary for the heads of regions and municipalities to pay increased attention to the formation and preservation of intangible competitive advantages of the territories under their jurisdiction.
Scientific and Technological Priorities in the Federal Spatial Development Policy in Russia
Authors: Kuznetsova О. V.
Published: January 2023

The need to activate and increase the effectiveness of science and technology policy in the modern conditions of the development of the Russian economy requires, among other things, the definition of spatial priorities of such a policy. It is proposed to assess the spatial component in the federal science and technology policy according to its compliance with such requirements as the widest possible coverage of territories with potential for scientific and technological development by federal support, the correctness of the assessment of such potential, the presence of a well-built system of support tools and compliance of higher education with the needs of scientific and technological development. It is shown that there are unresolved problems in each of these areas, including those related to the shortcomings of official statistics (there is no information on the actual number of researchers in the equivalent of full employment, on the structure of university students), with the disunity of measures to support scientific and technological development of territories (technological special economic zones, science cities, techno-parks in the field of high technologies, state scientific, innovative scientific-technological and scientific-educational centers), in some cases, insufficient elaboration of such measures. As a result, the geography of federal support for scientific and technological development develops spontaneously, spatial priorities of such a policy are not defined, the location of federal and national research universities does not always correspond to the location of research centers. The article suggests ways to solve these problems, including the development of a spatial strategy for scientific and technological development and embedding it into a new strategy for the spatial development of the country.
Antagonists Selective for NMDA Receptors Containing the NR2B Subunit
Authors: Chenard B. L. , Menniti F. S.
Published: January 2023

In the late 1980s, a new class of N-methyl-D-aspartate (NMDA) receptor antagonists, exemplified by the phenylethanolamine ifenprodil (1), was identified. Initially, the mechanism of action of ifenprodil was a mystery as it was not a competitive antagonist at the glutamate or glycine (co-agonist) binding sites, nor was it a blocker of the calcium ion channel associated with the NMDA receptor. Early studies with a novel polyamine binding site associated with the NMDA receptor and functional studies in various brain regions suggested a unique and selective activity profile for 1. However, it was not until the NMDA receptor subunits were identified and expressed that ifenprodil was shown to be a selective antagonist for a subset of NMDA receptors containing the NR2B subunit. The wide range of potential therapeutic targets for NMDA antagonists coupled with the hope that NR2B selective agents might possess an improved clinical safety profile compared to non-selective compounds has supported an aggressive effort to develop the structure-activity relationships (SAR) of NR2B selective antagonists. This SAR and the basic physiology of the NMDA receptor form the basis of this review.
Methicillin-Resistance in Staphylococcus aureus - Molecular Basis, Novel Targets and Antibiotic Therapy
Authors: Ehlert K.
Published: January 2023

Methicillin-resistant S. aureus are the major cause of nosocomial bacteremias showing a high morbidity rate in intensive care units. These strains are often resistant against almost all antibiotics in clinical use with the exception of vancomycin. However, the first isolation of a S. aureus strain with a diminished susceptibility to vancomycin from a hospitalized patient in Japan has been reported very recently. Therefore, current antibiotic therapy is difficult and expensive, often a combination of sev_eral antibiotics has to be used. For this reason novel antibiotics to combat staphylo­
coccal bacteremias, which prevent further spread of resistance are urgently needed. One approach might be the investigation of the mechanism of methicillin resistance, which is mediated by PBP2a, an additional penicillin- binding protein present in resistant strains with low affinity to 8-lactams. Beside PBP2a other housekeeping genes, the so called fem factors, are involved in expression of methicillin resistance. Two of these fem factors, the FemAB proteins, have been shown to participate in the formation of the pentaglycine crossbridge, which is a unique staphylococcal cell wall component. The biosynthesis of the pentaglycine side chains is not fully elucidated, but follows an interesting novel mechanism with unusual glycyl-tRNA as a substrate. Furthermore, inactivation of femA B, which have been reported as essential for bacterial growth, causes a completely restoration of antibiotic susceptibility in MRSA strains. Thus, these proteins might serve as attractive novel anti-staphylococcal targets for a small-range antibiotic.
2-Pyridylthioureas: Novel Nonpeptide Somatostatin Agonists with SST4 Selectivity
Authors: Crider A. M. , Liu S. , Tang C. , Ho B. , Ankersen M. , Stidsen C. E.
Published: January 2023

Somatostatin [somatotropin release-inhibiting factor (SRIF)] is a cyclic tetradecapcptiJc that is a potent inhibitor of growth hormone (GH) secretion from the anterior pituitary. In addition to the inhibitory effects on GH-release, SRIF-14 and SRJF-28, a 28-amino acid form of SRIF extended from the N-terminal end, inhibit the release of a variety of other peptides including glucagon, insulin, and gastriri, and both peptides act as neurotransmitters and neuromodulators in the central nervous system and the periphery. SRIF exerts its potent inhibitory effects following binding to high affinity SRIF receptors (ssts) that have been identified on target tissues. The recent cloning of five ssts has confirmed that the effects of SRIF are mediated by a family of G protein-coupled receptors (sst1-5). Based on structural and pharmacological properties sst2, sst3, and sst5 belong to the SRIF1 receptor subclass, and the sst1 and sst4 subtypes comprise the SRIF2 subclass. The major difference between these two subclasses is that SRIF1 receptors bind octapeptide and hexapeptide SRIF-14 analogs with high affinity, while SRIF2 receptors bind these analogs with drastically reduced affinity.
A screening program was initiated to identify a lead nonpeptide with affinity for sst1-5 receptors. The search focused on a scaffold with the following attachments: (I) a heteroaromatic nucleus to mimic the Trp8 residue, (2) a nonheteroaromatic nucleus to mimic Phe7, and (3) a primary amine or other basic group to mimic the Lys9
residue of SRIF-14. Using these criteria, a novel thiourea (NNC 26-9100, 17) was discovered as a structural lead. The key fragments in this compound are a heteroaromatic moiety (pyridine), an aromatic group, and a basic imidazole group connected through a thiourea scaffold. Compound 17 exhibited a Ki = 6 nM at sst4 receptors with a JOO-fold sst4/sst2 selectivity and was shown to be a full agonist at this receptor subtype. This article will review the literature on the design and development of nonpeptide somatostatin receptor ligands and the therapeutic potential of these agents. Furthermore, our work on the development of 2-pyridylthioureas as sst4 receptor agonists will be described.
Quantification of Vitamin D at Different Levels of Clinical Worsening of COVID-19
Authors: Tsun Lai Yu , Bibo Thaciane Alkmim , Affonso Fonseca Fernando Luiz , da Veiga Glaucia Luciano , Macedo Gaiatto Ana Carolina , de Godoy Moreira e Costa Nicolle , Raimundo Joyce Regina , Perez Matheus Moreira , Gascón Thaís , Scorza Fulvio Alexandre , Scorza Carla Alessandra , Nader Helena , Castello Girão Manoel João Batista , da Costa Aguiar Alves Beatriz , Pereira Edimar Cristiano
Published: January 2023

Introduction and Aim:

Vitamin D is the name given to a group of lipid-soluble steroidal substances of
physiological importance in the body, especially in bone metabolism. The active form of vitamin D is believed to
have immunomodulatory effects on immune system cells, especially T lymphocytes, as well as on the production and
action of several cytokines and on the expression of potent antimicrobial peptides in epithelial cells that line the
respiratory tract, playing an important role in protecting the lung from infections. The aim of this study was to assess
vitamin D levels in patients with COVID-19 in healthcare service and to verify that these levels are adequate to
protect the progression of this infection.

Methods:

The aim of this observational study was to evaluate the serum concentration of vitamin D in 300 patients
suspected of being infected with COVID-19, treated at Basic Health Units (BHUs) and at the Hospital Complex in
the municipality of São Bernardo do Campo.

Results:

294 patients were included, 195 (66%) of which tested positive for COVID-19 and 99 (34%) negative for
COVID-19. Among the patients in the positive group, 163 patients were in the mild group (84%); 22 patients in the
moderate group (11%); 8 patients in the severe group (4%), and 2 patients in the deceased group (1%).

Conclusion:

For the patients in this study, no association was observed for the protective factor of vitamin D against
COVID-19 infection, and its role in controlling the clinical staging of the disease was not verified.
Clinical Evidence and Practice-Based Guidelines on the Utility of Basal
Insulin Combined Oral Therapy (Metformin and Glimepiride) in the
Current Era
Authors: Shrivastava Abhishek , Kesavadev Jothydev , Mohan Viswanathan , Saboo Banshi , Shrestha Dina , Maheshwari Anuj , Makkar Brij Mohan , Modi Kirtikumar D. , Kumar  Das Ashok
Published: January 2023

Background and Aim:

Basal insulin combined oral therapy consisting of insulin and
oral anti-diabetic drugs (OADs) is recommended for type 2 diabetes uncontrolled on OADs. There
is a lack of clear evidence and recommendations on the combined use of basal insulin analogues to
more than one OADs (glimepiride plus metformin) in effective control of glycemic parameters and
its safety in terms of reduced hypoglycemic events, weight gain and cardiovascular risk. In this
context, a group of clinical experts discussed the utility of basal insulin combined oral therapy with
metformin and glimepiride in the current era.

Methods:

The clinical experts discussed and provided their inputs virtually. The expert panel included
clinical experts comprising endocrinologists and diabetologists from India and Nepal.

Results:

The panel thoroughly reviewed existing literature on the subject and proposed clinical evidence
and practice-based guidelines.

Conclusion:

These current clinical practice guidelines highlight the efficacy and safety of basal insulin
combination therapy with various available basal insulins including neutral protamine hagedorn,
detemir, glargine and degludec in addition to metformin and glimepiride therapy.
Plant-sourced Antioxidants in Human Health: A State-of-Art Review
Authors: Alara Oluwaseun Ruth , Ukaegbu Chinonso Ishmael , Abdurahman Nour Hamid , Alara John Adewole , Ali Hassan Alsaggaf
Published: January 2023

Nowadays, free radical chemistry is a field that has gained the wider attention of researchers.
Our body generates free radicals’ reactive nitrogen and oxygen species through subjection
to several pathological states, endogenous systems, and physicochemical conditions. For
the physiological state to occur, it is compulsory to propel a balance between antioxidants and
free radicals. Oxidative stress will set in when free radicals can no longer be regulated in the
body system. Moreover, free radicals negatively affect DNA, protein, and lipids and cause many
diseases in the human body. Thus, natural-sourced antioxidants can be used to manage this oxidative
stress. Currently, it has been revealed that some synthetic antioxidants, including butylated
hydroxyanisole and butylated hydroxytoluene, are hazardous to human health. Therefore, many
efforts have been made in search of natural, non-toxic, and effective compounds that possess anti-
oxidative properties. Hence, this review comprehensively presents the roles of plant-based antioxidants
in resolving the challenging issues associated with free radical diseases in human beings.
It further reviews the characteristics and occurrences of free radicals in the human body, the
formation and mechanism of free radicals, some of the physiological impacts of free radicals on
human health, sources of free radicals, and plant-sourced antioxidants as a frontier in managing
free radicals.
Diagnostic Challenge and Management of Thymic Cavernous Hemangioma:
A Case Report and Review of the Literature
Authors: Liu Li , Zhang Fangbiao , Wu Zhijun , Tu Shaosong , Li Yan
Published: January 2023

Objective:

Thymic cavernous hemangioma (CH) as a benign lesion is extremely rare, and it
is very difficult to distinguish it from other anterior mediastinal tumors on imaging.

Case Presentation:

We treated a 63-year-old woman with thymic CH that was incidentally found by
chest computed tomography (CT). Contrast-enhanced chest CT described an anterior superior mediastinal
mass, approximately 2.5cm in diameter, with centripetal enhancement and an increased range of
enhancement in the delayed period. The tumor and thymus were completely resected by video-assisted
thoracic surgery (VATS) to provide a definitive diagnosis and precise treatment. Postoperative pathology
suggested that the tumor was a thymus cavernous hemangioma.

Conclusion:

We reported an extremely uncommon case of CH in the thymus and reviewed the previously
published literature. CH can occur at any age and body tissue, and there is no significant difference
between males and females. Most patients are asymptomatic, often found by chest CT. Enhanced
chest CT suggested that an increased area of venous enhancement at a prolonged duration may be a
feature of CH. Complete surgical resection is a safe and effective method for CH in the thymus.
Chest CT Features of Patients with COVID-19 Pneumonia Following
Hospital Discharge
Authors: Qiao Zhenguo , Hu Chunhong , Liu Dong , Fu Fangfang , Ye Aihua
Published: January 2023

Objective:

To evaluate chest computed tomographic (CT) findings in patients with coronavirus disease 2019 (COVID-19) pneumonia following hospital discharge.

Methods:

52 patients with confirmed COVID-19 pneumonia underwent follow-up chest CT. The scans were obtained on average 43.1 days after hospital admission and analyzed for parenchymal abnormality (e.g., ground-glass opacities, consolidation, or interstitial thickening) and evidence of fibrosis (e.g., assigned to one of three groups: Group 1 (normal lung), Group 2 (parenchymal abnormality but without evidence of fibrosis), and Group 3 (evidence of fibrosis)). Clinical data and CT manifestations of the patients were compared among the three groups.

Results:

30.8% (16/52) of patients with COVID-19 pneumonia showed normal lung and were designated as Group 1. 69.2% (36/52) of patients showed parenchymal abnormality ranging from residual ground-glass opacities, consolidation, or interstitial thickening in Group 2 (51.9%) to fibrosis in Group 3 (17.3%). All patients in Group3 had severe/critical COVID-19, while most patients in Group 2 and Group 1 had common COVID-19. Patients in Group 3 were older (60.9 vs 40.8 and 36.8 years, p<0.001, there is a significant difference), had a longer hospitalization day (20.2 vs 15.3 and 12.3 days, p<0.05, there is a significant difference), a higher ratio of patients with comorbidities (88.9%vs14.8% and 25%, p<0.001, there is a significant difference), and higher peak CT scores (13 vs 6.2 and 3.2, p<0.001, there is a significant difference) than those patients in Group 2 and Group 1.

Conclusions:

Elderly severe/critical COVID-19 patients with comorbidities are more prone to develop fibrosis early on following hospital discharge. On the other hand, lung inflammation in younger patients with common COVID-19 can be resolved completely.
Modulatory Action of Voltage Gated Ion Channels in Inflammation and Inflammatory Pain
Authors: Rajagopal Senthilkumar
Published: January 2023

Pain is “an unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described by the patient in terms of such damage”. The origin of every pain syndrome is inflammation. A group of voltage-gated channels that are permeable to calcium ions enhances sensory transduction witnessed during inflammation. Hence, understanding calcium signaling is an essential step towards recognizing neural network activity associated with pain management. In this review, we attempted to understand the impact of calcium-permeable ion channels in the recognition, processing, transduction and modulation of pain signals. Results obtained revealed that calcium being one of the most ubiquitous secondary messengers play a significant role in modulating numerous biological processes, including inflammation and pain. Though almost all subtypes of calcium channels are highly expressed in the central nervous system (CNS), the “N-type calcium ion-channels” play an important function at the time of neurotransmitter release from the afferent terminals within the spinal dorsal. Hence, they serve as a key therapeutic target during the treatment of analgesics. Migraine is also reported to involve neurogenic inflammation. “P/Q-type calcium channels” is suggested to have important role in migraine. The inhibition of these channels through various analgesics serves as a treatment against inflammatory and neuropathic pain. However, few of these inhibitors have numerous side effects, including cancer. Hence, these inhibitors may be consumed under the supervision of medical practitioners. In this review, we revealed the understanding and regulation of ion channels in inflammation causing pain and its treatment.
Bioactive Potential of Artocarpus heterophyllus Lam.: PRISMA Based
Review
Authors: Singh Sonia , Gupta Anushka , Gupta Neha
Published: January 2023

Introduction:

In India, the plant Artocarpus heterophyllus Lam. is commonly known as
"Jackfruit" and has been generally used as food and in many traditional medicines.

Objective:

The present manuscript aimed to collect description information on phytochemistry, ethnomedical
uses, pharmacological activities, and patent of A. heterophyllus Lam. that may help in
making a bridge between the research gaps as well as the upcoming future findings.

Materials and Methods:

The literature survey was based on a PRISMA systematic study that gathered
information from various sources, including journals, e-books, and digital databases such as
Scopus, Web of Science, Pubmed, and Science Direct from 1991 to 2021.

Results:

Several bioactive constituents are characterized, including flavonoids, chalcones, flavanols,
terpenoids, stilbenoids, and xanthones in the fruit. It also contains tannins, quercetin, gallic acid,
saponins, artocarpanone and artocarpin. Many pharmacological studies stated the therapeutic potential
of Jackfruit, such as antioxidant, antimicrobial, anti-inflammatory, antifungal, anticancer, and
antidiabetic properties.

Conclusion:

The present manuscript summarizes the phytochemistry and pharmacological properties
of A.heterophyllus Lam. And it is also providing information in-vitro and in-vivo concerning
experimental studies with patent data which, in turn, makes the herbal drug a promising source in
the nutrition and therapeutic aspects.
Wisdom to attain happiness in Vedic culture perspective
Authors: Yulianti Ni Ketut Dewi
Published: January 2023

This paper discusses about wisdom to attain happiness. Happiness is experienced when the soul attained peace, while peace can be attained when people have wisdom. Wisdom is often understood by different perspectives. Therefore, in this paper, it is explained from the perspective of the Vedic culture perspective, namely of the scripture Srimad-Bhagavatam (Vedanta Sutra), which is the highest source of knowledge. This paper can be used as a reference especially for students and teachers who want to go deeper into character education, since self-realization – which is the foundation of character education – is also a part of wisdom. There are two topics discussed in this paper, namely (a) wisdom influenced by the three modes of material nature and (b) the real wisdom to attain real happiness. The real wisdom referred to here is the wisdom that begins from self-realization. Theoretically, this paper will be able to contribute to the world of education especially in the field of character education, so that it can contribute to the successfulness of the national education.
Environmental Conservation Based on Community Empowerment: Case Study in Toba Caldera UNESCO Global Geopark
Authors: Simandjorang Bonataon Maruli Timothy Vincent , Gunawan Fransiskus Xaverius Candra , Mesa Asinkritus Ngongo Lalu Manu , Apriani Tini , Pranasari Melati Ayuning , Putra Imam Radianto Anwar Setia , Fitri Suci Emilia
Published: January 2023

Toba Caldera UNESCO Global Geopark (TCUGG) has not only geological phenomena of international geological significance value but also has outstanding universal value by the United Nations Educational, Scientific and Cultural Organization (UNESCO). The establishment of TCUGG as a national priority and the Lake Toba Authority Agency is a serious commitment from the government to develop this region. Although it is now a super-priority tourism destination, over the last six decades, the water level of Lake Toba has decreased significantly by 2.4 cm per year from 1957 to 2016. The environmental quality index shows a decline from year to year, and environmental conditions of Lake Toba are already very severe due to various factors. The government and local communities are still running independently for the conservation agenda. This empirical research uses a mixed method of sequential explanation. The main objective of the research is to analyze the determinants of local people's choices to participate in conservation activities in TCUGG. From the research results, the significant factors that determine the local communities' participation in conservation activities are water availability, incentives, suitability of seeds, trust level for the initiator, and the success rate of previous conservation. Society does not need promises or rhetoric, especially for those who have participated before and experienced low success rates. Application of reward and punishment as an incentive for the community to participate in conservation activities and to further encourage their motivation. The main key is to serve the needs of the community in conservation practices.
Fiscalidad, territorios y globalización: evidencia para Uruguay (c. 1852-1913)
Authors: Martínez Rodríguez Camilo
Published: January 2023

Este artículo aborda la construcción fiscal en Uruguay circa 1852 y 1913 desde una óptica subnacional. Se utilizan Memorias de Hacienda y Estados de Cuenta de la Nación para la construcción de indicadores subnacionales vinculados con la participación departamental en la recaudación de impuestos directos e indirectos. Se construye una tipología con base en estos indicadores que agrupa a los territorios de acuerdo con su desempeño fiscal. Al cierre del período, los resultados indican que el eje central de la fiscalidad uruguaya se encontró en Montevideo, Canelones y en los departamentos con receptorías portuarias en el Río Uruguay, siendo menor el aporte de los territorios sin receptorías portuarias o aquellos con receptorías en la costa del Océano Atlántico.
Patient and caregiver satisfaction regarding telepractice versus in-person services at a university speech, language, and hearing clinic
Authors: Kim Sojung , Roman Aaron M. , Moore Alexandra
Published: January 2023

Purpose: The purpose of the pilot study is to explore patient and caregiver (i.e., spouse, parent, grandparent, child, and grandchild) satisfaction regarding telepractice versus in-person services provided at a university speech, language, and hearing clinic.Methods: Survey data were collected from 70 respondents (24 received in-person services only, 13 received telepractice only, and 33 received both in-person services and telepractice) during the onset of the COVID-19 pandemic.Results: Results indicated that patients and caregivers rated overall in-person services significantly higher than the overall telepractice services. Patients’ and caregivers’ perceived technology skills were not significantly related to their satisfaction of telepractice. However, graduate clinicians’ technology skills, professionalism, and the quality of materials used in sessions were significantly associated with patients’ and caregivers’ satisfaction of telepractice. Also, patients’ and caregivers’ interaction with graduate students and supervisors was significantly correlated to their satisfaction of telepractice.Conclusions: Areas of improvement for telepractice-based services were discussed. The significance of adopting telepractice clinical and technical skills in preservice speech-lan¬guage pathology pedagogy was also highlighted.
Prevalence of tongue-tie and evaluation of speech sound disorder in young children
Authors: Ghayoumi-Anaraki Zahra , Majami Fatemeh , Farahnakimoghadam Fatemeh , Karbaf Barbari Seyede Mohadeseh Zohour , Tahmasebifard Neda , Sarabadani Javad
Published: January 2023

Purpose: Tongue-tie is a common congenital abnormality whose effect on speech sound disorders is controversial. The first purpose of this study was to determine the prevalence of tongue-tie in Persian speaking children aged 3–6 years. Second, compare the speech sound errors of children with tongue-tie with those of children without tongue-tie.Methods: 487 (206 female, 281 male) children aged 3–6 years were recruited for this study. Descriptive statistics were used to determine the prevalence of tongue-tie. Fisher’s exact test was performed to compare the speech sound errors of children with and without tongue-tie.Results: The prevalence of tongue-tie in children was 14.9%. These children showed a statistically significant difference in the production of the /s/, /z/, and /l/ sounds in both the initial and final positions of the word and the /t/ sound in the initial position of the word.Conclusions: While it is theoretically expected that the tongue-tie affects the production of anterior sounds, our clinical study shows speech sound disorder in only a limited number of cases. Therefore, it seems that surgical intervention on tongue-tie for sole purpose of speech improvement should be performed cautiously.
Deep-Learning Model for Influenza Prediction From Multisource Heterogeneous Data in a Megacity: Model Development and Evaluation
Authors: Yang Liuyang , Li Gang , Yang Jin , Zhang Ting , Du Jing , Liu Tian , Zhang Xingxing , Han Xuan , Li Wei , Ma Libing , Feng Luzhao , Yang Weizhong
Published: January 2023

Background

In megacities, there is an urgent need to establish more sensitive forecasting and early warning methods for acute respiratory infectious diseases. Existing prediction and early warning models for influenza and other acute respiratory infectious diseases have limitations and therefore there is room for improvement.

Objective

The aim of this study was to explore a new and better-performing deep-learning model to predict influenza trends from multisource heterogeneous data in a megacity.

Methods

We collected multisource heterogeneous data from the 26th week of 2012 to the 25th week of 2019, including influenza-like illness (ILI) cases and virological surveillance, data of climate and demography, and search engines data. To avoid collinearity, we selected the best predictor according to the weight and correlation of each factor. We established a new multiattention-long short-term memory (LSTM) deep-learning model (MAL model), which was used to predict the percentage of ILI (ILI%) cases and the product of ILI% and the influenza-positive rate (ILI%×positive%), respectively. We also combined the data in different forms and added several machine-learning and deep-learning models commonly used in the past to predict influenza trends for comparison. The R2 value, explained variance scores, mean absolute error, and mean square error were used to evaluate the quality of the models.

Results

The highest correlation coefficients were found for the Baidu search data for ILI% and for air quality for ILI%×positive%. We first used the MAL model to calculate the ILI%, and then combined ILI% with climate, demographic, and Baidu data in different forms. The ILI%+climate+demography+Baidu model had the best prediction effect, with the explained variance score reaching 0.78, R2 reaching 0.76, mean absolute error of 0.08, and mean squared error of 0.01. Similarly, we used the MAL model to calculate the ILI%×positive% and combined this prediction with different data forms. The ILI%×positive%+climate+demography+Baidu model had the best prediction effect, with an explained variance score reaching 0.74, R2 reaching 0.70, mean absolute error of 0.02, and mean squared error of 0.02. Comparisons with random forest, extreme gradient boosting, LSTM, and gated current unit models showed that the MAL model had the best prediction effect.

Conclusions

The newly established MAL model outperformed existing models. Natural factors and search engine query data were more helpful in forecasting ILI patterns in megacities. With more timely and effective prediction of influenza and other respiratory infectious diseases and the epidemic intensity, early and better preparedness can be achieved to reduce the health damage to the population.
COVID-19 Vaccination Reactions and Risk of Breakthrough Infections Among People With Diabetes: Cohort Study Derived From Community Reporters (Preprint)
Authors: Dreyer Nancy A , Knuth Kendall B , Xie Yiqiong , Reynolds Matthew W , Mack Christina D
Published: January 2023

BACKGROUND

This exploratory study compares self-reported COVID-19 vaccine side effects and breakthrough infections in people who described themselves as having diabetes with those who did not identify as having diabetes.

OBJECTIVE

The study uses person-reported data to evaluate differences in the perception of COVID-19 vaccine side effects between adults with diabetes and those who did not report having diabetes.

METHODS

This is a retrospective cohort study conducted using data provided online by adults aged 18 years and older residing in the United States. The participants who voluntarily self-enrolled between March 19, 2021, and July 16, 2022, in the IQVIA COVID-19 Active Research Experience project reported clinical and demographic information, COVID-19 vaccination, whether they had experienced any side effects, test-confirmed infections, and consented to linkage with prescription claims. No distinction was made for this study to differentiate prediabetes or type 1 and type 2 diabetes nor to verify reports of positive COVID-19 tests. Person-reported medication use was validated using pharmacy claims and a subset of the linked data was used for a sensitivity analysis of medication effects. Multivariate logistic regression was used to estimate the adjusted odds ratios of vaccine side effects or breakthrough infections by diabetic status, adjusting for age, gender, education, race, ethnicity (Hispanic or Latino), BMI, smoker, receipt of an influenza vaccine, vaccine manufacturer, and all medical conditions. Evaluations of diabetes medication-specific vaccine side effects are illustrated graphically to support the examination of the magnitude of side effect differences for various medications and combinations of medications used to manage diabetes.

RESULTS

People with diabetes (n=724) reported experiencing fewer side effects within 2 weeks of vaccination for COVID-19 than those without diabetes (n=6417; mean 2.7, SD 2.0 vs mean 3.1, SD 2.0). The adjusted risk of having a specific side effect or any side effect was lower among those with diabetes, with significant reductions in fatigue and headache but no differences in breakthrough infections over participants’ maximum follow-up time. Diabetes medication use did not consistently affect the risk of specific side effects, either using self-reported medication use or using only diabetes medications that were confirmed by pharmacy health insurance claims for people who also reported having diabetes.

CONCLUSIONS

People with diabetes reported fewer vaccine side effects than participants not reporting having diabetes, with a similar risk of breakthrough infection.

CLINICALTRIAL

ClinicalTrials.gov NCT04368065; https://clinicaltrials.gov/study/NCT04368065
Pride and Prejudice Book vs. Play
Authors: Zhang Grace , Tosun Tulin Ece
Published: January 2023

Since first published in 1813, Jane Austen’s novel Pride and Prejudice has remained to be a timeless classic and has continued to inspire many adaptations in different artistic forms. The novel explores pride in Mr. Darcy’s character and prejudices in Elizabeth Bennet’s nature. In the beginning, excessive pride and prejudices prevent them from admiring each other’s virtue and beauty. As the story progresses, though, readers see both their growth and, finally, a happy ending after pride and prejudices fade. Because it tells one of the most cherished love stories in English literature, the original novel has been adapted to plays, movies, and TV series—but unfortunately, not every production is at the same level of quality. The wonderful experiences of going to the Pride & Prejudice (2005) movie screening and watching BBC’s Pride and Prejudice (1995) TV series had raised my expectation for other adaptations of the novel, so I couldn’t wait to go to Aquila Theatre’s play production. However, it was a disappointment and I have since been curious to find out why I felt that it did not meet my expectation: I love the book, the movie, and the TV series, so why can’t I like Aquila Theatre’s play adaptation as well? In this paper, I will argue that I don’t think Aquila Theatre’s production is a good adaptation of the original work, based on how the play differently portrays Mr. Collins’s character and manners, Elizabeth Bennet, and her relationship with Mr. Darcy. • How did Jane Austen portray each character when writing the book? • How did Aquila Theatre differently portray each character when directing the play? • What is the message Jane Austen tries to send through her novel Pride and Prejudice? • What are some reviews of Aquila Theatre’s production of Pride and Prejudice?
Periodismo de paz para la migración
Authors: Mondragón Aguilar Susana Jeanine
Published: January 2023

Es interés de este artículo abordar la cobertura sobre la migración en dos medios digitales mexicanos, que muchas veces se limitan a reportar el fenómeno como suceso de urgencia, donde lo relevante son las cifras de migrantes que buscan llegar a la frontera norte del país, las rutas de migración y los actos de violencia vinculados a estos desplazamientos. En el artículo se discute la necesidad de construir narrativas periodísticas sobre la migración que la aborden desde propuestas informativas variadas, pues mirarla desde el discurso informativo implica sumar formas de comprenderla como fenómeno de la modernidad, además de establecer una agenda con distintos ángulos respecto a la complejidad del fenómeno, desde una visión del llamado periodismo de paz y sobre todo presentar información cimentada en una especialización en el tema.
Exploración del desarrollo de competencia interdisciplinar en formadores de docentes mediante el diseño de proyectos estadísticos
Authors: Espino-Flores Gessure Abisaí , Gómez-Blancarte Ana Luisa , Inzunza Cazares Santiago
Published: January 2023

Los enfoques actuales de los Planes de Estudio de la Educación Media Superior y Superior en México demandan desarrollar conocimientos interdisciplinarios que exigen una articulación de saberes provenientes de distintas disciplinas a fin de abordar problemas complejos. Ante estas demandas, los docentes enfrentan desafíos para, entre otros asuntos, diseñar e implementar estrategias de enseñanza que atiendan el trabajo interdisciplinar en sus aulas. En este artículo reportamos avances de una investigación más amplia que estudia el uso de proyectos estadísticos como un recurso para fomentar una competencia interdisciplinar. Basados en la revisión de literatura, definimos cuatro características de esa competencia: comprensión disciplinar, integración disciplinar, reflexividad, y, producción e intercambio de objetos limitáneos. El objetivo del artículo es explorar el desarrollo de esas características por parte de formadores de docentes de diferentes áreas disciplinares durante la planificación de un proyecto estadístico. Los resultados dan cuenta de, por un lado, la complejidad que demanda para los formadores encontrar y formular un problema de investigación que articule sus conocimientos disciplinares; por otro, la potencialidad que parece tener el diseño y planificación de proyectos estadísticos para impulsar el desarrollo de las características que definen una competencia interdisciplinar
Estructuras virtuales, emergencias materiales y ensamblajes sociales. De Gilles Deleuze a Manuel DeLanda
Authors: Villalobos Manjarrez Alberto
Published: January 2023

En principio, este texto consiste en el desarrollo de la continuidad que existe entre dos estructuras ontológicas, desde las cuales se explica la formación histórica de diversos procesos y emergencias materiales. Estas estructuras son el par virtual/actual, definido por Gilles Deleuze; y el espacio de posibilidades, conceptualizado por Manuel De Landa. A continuación, se expone por qué en el proyecto filosófico de De Landa se realiza una naturalización relativa de la ontología de Deleuze. Después, se presenta una explicación tentativa sobre la formación de diversos ensamblajes sociales concernientes a los animales y los seres humanos, a través de ciertas condiciones, emergencias y acumulaciones materiales, cuyas determinaciones acontecen a partir de la estructura virtual del espacio de posibilidades. Para concluir este trabajo, se pregunta por los límites y la universalidad de estas estructuras virtuales, en relación con sus capacidades para constituir la forma según la cual transcurre la historia material.
El espectador comprometido: Entrevista a Ramón Rodríguez
Authors: Romero Granados José Ricardo
Published: January 2023

Charla con el destacado académico del departamento de filosofía de la Universidad Complutemse de Madrid (UCM), Ramón Rodríguez García. Los temas abordados giran alrededor de la obra de Martin Heidegger, su apropiación en España, la tradición fenomenológica, una visión crítica del nuevo realismo y la hermenéutica.
El género Auricularia (Agaricomycotina: Basidiomycota) en México
Authors: Rodríguez-Gutiérrez Ibeth , Garibay-Orijel Roberto , Sierra Sigfrido , Jiménez-Zárate Jesús , Cervantes-Chávez José Antonio , Villarruel-Ordaz José Luis , Landeros Fidel
Published: January 2023

Anteriormente, se asumía que las especies del género Auricularia eran cosmopolitas por ser saprobias. Ahora se sabe que las 2 especies más citadas en el mundo, A. auricula-judae y A. mesenterica, son complejos de especies y no están distribuidas en América. Los estudios en México sobre el género basados en morfología, hasta antes de este trabajo, reconocían un total de 10 especies: A. auricula-judae, A. cornea, A. delicata, A. fuscosuccinea, A. mesenterica, A. nigricans, A. peltata, A. polytricha, A. tenuis y A. tremellosa. Este estudio se basó en la revisión de materiales de los herbarios más representativos de México y en análisis filogenéticos de la región ITS del ADNr para comparar con otros estudios alrededor del mundo. Los resultados indican que en México se distribuyen 8 especies: se confirman los reportes de A. cornea, A. fuscosuccinea, A. nigricans y A. tremellosa, y se registran por primera vez para México A. americana, A. angiospermarum, A. brasiliana y A. scissa. En contraste, no pudimos comprobar la presencia en México de A. auricula-judae, A. delicata, A. mesenterica, A. peltata, A. polytricha y A. tenuis.
First report of the Philornis torquans complex in adult birds in continental Ecuador: Is parasitism by Philornis being underestimated?
Authors: Cadena-Ortiz Héctor , Quiroga Martín , Bonaccorso Elisa
Published: January 2023

Myiasis by Philornis is a usual phenomenon in Neotropical birds. Philornis larvae are hematophagous and are known to affect both nestlings and adults. Still, parasitism in adults seems opportunistic and has been poorly studied compared to parasitism in nestlings. Here, we inspected 1,429 adult and juvenile birds of 41 species from an Andean dry forest in northern Ecuador, searching for infestations by Philornis larvae. For the first time, we report parasitism by Philornis in adult birds of 6 species of passerine birds (Troglodytes aedon, Conirostrum cinereum, Geospizopsis plebejus, Zonotrichia capensis, Pheucticus chrysogaster, and Spinus magellanicus). We also report the first cases of infestation by the Philornis torquans complex in Ecuador and provide data on the prevalence of Philornis myiasis in this Andean dry forest. We extend both the host range and the geographic distribution of the P. torquans complex.
Redes tróficas como herramienta para el estudio de la diversidad y complejidad de ecosistemas
Authors: Abarca-Arenas Luis Gerardo , Valero-Pacheco Elizabeth , Delfín-Alfonso Christian A. , Morteo-Ortiz Eduardo , Franco-López Jonathan
Published: January 2023

Considerando el creciente deterioro del medio ambiente y los efectos nocivos que alteran la riqueza de especies, es importante encontrar la metodología adecuada para el estudio de la diversidad y su manejo. La presente revisión presenta una breve reseña histórica del análisis de redes tróficas, los distintos tipos y métodos de análisis de éstas. Las redes no ponderadas, aunque sencillas en su construcción, representan aspectos estructurales y de diversidad de manera cuantitativa. Las redes ponderadas tienen la ventaja de conocer el flujo de materia entre las especies, sin embargo, la cantidad y calidad de datos necesarios es muy grande y difícil de obtener. Las redes bipartitas, que pueden ser ponderadas o no, son un caso especial útil en estudios de biogeografía o parasitismo. Para los 3 tipos de redes es posible medir características como riqueza de especies, diversidad de flujos y especies, entre otros índices topológicos de las redes útiles para la toma de decisiones en el manejo de los sistemas ecológicos.
Morfología del polen de Lonchocarpus sección Punctati (Fabaceae: Papilionoideae)
Authors: Pérez-Chávez Itzel , Sotuyo Solange , Torres-Colín Leticia
Published: January 2023

Se describe la morfología del polen en 14 especies representantes de Lonchocarpus sección Punctati (L. adamsii, L. angusticarpus, L. benthamianus, L. berriozabalensis, L. cochleatus, L. glaucifolius, L. longipedicellatus, L. longipes, L. longistylus, L. major, L. michelianus, L. punctatus, L. tenorioi y L. vallicola). Los granos de polen fueron acetolizados y se examinaron bajo microscopio electrónico de barrido. Los resultados encontrados aportan información, por primera vez, sobre su morfología en esta sección. El tamaño es pequeño, con formas variadas como el prolado esferoidal, subprolado, oblado esferoidal, hasta el suboblado. La ornamentación de la exina, en la mayoría de las especies, es rugulada, aunque en algunas otras se observó foveolada, microreticulada o verrugada. En todas las especies seregistraron 3 aberturas del tipo colporado, con una membrana granular.
Blockchain in Real Estate
Authors: Shelke Dr. Priya , Sangle Praveen , Saswadkar Shubham , Gundawar Puru , Kadale Keshav
Published: January 2023

Abstract: Real estate plays an important role in the national economy, but the existing system has many flaws that affect everything from finding a property to renting to buying and selling. Real estate and blockchain have the potential to work well together. In order to strongly support the premise of real estate in multiple wearing exercises, the land business process utilizes a blockchain model. Either way, the majority of digital data is enabled across multiple frameworks, putting an end to a lack of transparency and an increased rate of errors that create more obvious potential for fraud. Blockchain technology has the potential to improve apartment trading activities. A new strategy for companies that are steadily revealing some of these facts is the un-middle of blockchain for a real estate approach.
Scientometric analysis of research in the field prefabricated construction
Authors: Gurinovich Vitaliy Yu. , Leonovich Sergey N. , Pozdnyakov Dmitriy A.
Published: January 2023

Introduction. State policy in the field of housing construction, providing the increase in the volume and decrease in the cost of housing construction, promotes to the development of prefabricated construction. In its turn, the increase in the prefabricated construction requires studying and introducing modern organizational and technological solutions for the erection of buildings and production of precast reinforced concrete structures, determining the directions of improvement of prefabricated construction.

Materials and methods. To study the development and effectiveness of prefabricated construction, actual directions and tendencies of scientific research in the field of prefabricated construction, the structure of citation of publications, key researchers, leading countries, institutions, scientific journals a scientometric analysis was carried out based on the SciVal analytical system using visualization tools, quantitative and qualitative scientometric metrics.

Results. Analysis of research trends in the field of construction and building technologies in the world has shown that prefabricated construction is one of the most intensively developing and promising areas of research. The main subjects of research in the field of prefabricated construction are design and information modeling, organization of prefabricated construction and production, delivery of structures to the building site and their assembling, at that, less attention is paid to the research in the field of production technologies of precast reinforced concrete structures in the factory conditions and production management, for which further research in these directions is needed. Studies of the development of industrial house-building in the practice of housing construction have shown that the efficiency of prefabricated construction must be considered in the context of a particular country or region and evaluated by applying a systematic analysis of costs and benefits.

Conclusions. The results of the executed scientometric analysis make it possible to identify trends, priority areas for further scientific research and their relationship with other areas of science, and can be a scientific basis for identifying gaps in current research in the field of prefabricated construction.