bluuebunny/crossref_metadata_2025 huggingface dataset:
Dyslipoproteinemias in postmenopausal women and new therapeutic targets
Authors: Romero Galván Edison Edgardo
Published: August 2024

Dyslipoproteinemias play a very prominent role in the pathogenesis of atherosclerosis in postmenopausal women; These lose the cardiovascular protection of estrogens, increasing the risk of developing atherothrombotic vascular disease (CVD). International guidelines do not vary between the management of dyslipidemia between men and women, but these are treated less vigorously and without taking into account the postmenopausal hormonal situation. Its management must be included in the individual risk of each woman, with the new LDL goals and above all take into account Lipoproteins rich in Triglycerides (LPRTG) that are associated with the classic modifiable risk factors, in a non-modifiable biological terrain such as are age and genetic family history; which may be associated with emerging factors such as Lipoprotein “a” (Lp a), hyperhomocysteine, elevated CRP (C-reactive protein), among other factors that are rarely taken into account. Statins demonstrated their effectiveness in reducing LDL and even increasing HDL, reducing cardio and cerebrovascular events, but a good percentage of patients, despite the intensified doses, remain at Residual Lipid Risk, so we must resort to new therapeutic targets. like biological ones.
Giant pelvic solitary fibrous tumor. Presentation of a rare case
Authors: Sofoudis Chrisostomos , Charitaki Evgenia , Alifieris Konstantinos , Delis Spiros
Published: August 2024

Solitary fibrous tumors (STFs) consist a very rare and unique group of neoplasms throughout the entire human system. Basic histopathologic origin represents the mesenchymal tissue with slight exceptions. Major incidence obtains the pleura with anatomic occupations especially in the limps, necks and gastrointestinal tracts. Surgical dissection represents the gold standard of therapeutic strategy. According to recent bibliography, only a few cases have been described arising from anatomic areas from mesentery and colon. Aim of our study consists the presentation of such rare tumor group accompanied with assiduous diagnosis and therapeutic mapping.
Large-scale agro-industries and host community land restitution demands: understanding the land-use conflicts between the CDC and Fako elites in the south west region, Cameroon
Authors: Bomono Henri Yambene , Nkwain Ndoh Lawrence , Simun Reine Fosso , Nkenne Jean-Marie
Published: August 2024

Large-scale land acquisition has been frequent in most parts of Africa. This frequently led to extensive dispossession among other pitfalls of violation of indigenous land ownership rights. A significant proportion of Fako division’s fertile slopes and plains were expropriated by the Germans for implantation and development of plantations. Ownership rights of indigenous community lands were transferred without the legal consent of the rightful native authorities. Against the backdrop of this colonial intrusion and consequential violations of local customary tenure rights, the growing need for justice and restoration of dignity has been a shared value among a preponderant proportion of the local Bakweri ethnic group. This culminated to a restitution decision of CDC leased lands to the Bakweri by the African Commission on Human and People’s Rights. Nonetheless, the proportion of restituted lands has not been significant and satisfactory enough to conciliate the expropriated host communities of the extensive CDC leaseholds. As such, landownership contestations and its consequential socio-political tensions still persist in Fako. This paper is centered on yet a more frequently expressed contestation: encroachment into and occupancy of CDC leaseholds by natives of Fako as a whole and Ndongo of Tiko sub-division in particular. Prior extensive documentary review was done which pointed to the locality of Ndongo as a suitable case of interest. Contrary to the general land grabbing tendencies of agro-businesses, community members here are accused of unauthorized intrusion into and tenancy of lands with legal ownership rights belonging to the CDC. The study was ethnographic comprising of individual in-depth interviews and observations.
Stratifikasi Sosial pada Tokoh-Tokoh Naskah Drama Nyonya-Nyonya Karya Wisran Hadi
Authors: Solahudin Satiri , Zahrani Nadilah
Published: August 2024

In every society, it is not strange for us to find the existence of different levels of social class or social position. Starting from the existence of class differences in society, an idea emerged, namely social stratification. Social stratification takes many forms. However, the researcher chose social stratification based on the class level in the society, criteria of honor, economy, and position or status in the society. The researcher proves the forms of social stratification through dialogue contained in the drama script of Nyonya-nyonya. The purpose of this study is to describe the social stratification depicted in Wisran Hadi's drama Nyonya-Nyonya. The research method used in this study is qualitative descriptive method with a notetaking technique. The results of the analysis prove that every character in the drama script of Nyonya-Nyonya contains forms of social stratification which are depicted through dialogue. The data in this study are 11 data, including the form of social stratification for upper class, middle class, upper class with honor criteria, as well as aspects of ascribed status and achieved status.
Static Analysis for Scala
Authors: Afanasyev Vitaly Olegovich , Borodin Alexey Evgenevich , Belevantsev Andrey Andreevich
Published: August 2024

The paper describes a static analyzer for finding defects in Scala programs. The proposed analysis scheme uses JVM bytecode produced during compilation. The generated bytecode is used as an input for inter-procedural static analyzer Svace. In contrast to the analysis of other languages supported by Svace, in this work we describe an approach that does not require compiler modifications and therefore simplifies language support. This approach can also be used in static analyzers that aim to support a large number of programming languages.
Automating the Process of Responding to a Tax Request Using Weak Supervision
Authors: Sosnovikov Artur Dmitrievich , Turdakov Denis Yurievich
Published: August 2024

This paper examines the application of weak observation techniques to automate tax claim processing in the banking sector. Interest in process automation using machine learning and artificial intelligence techniques in the financial sector has grown significantly in recent years, driven by the desire to improve efficiency, accuracy and customer service. Previous research in financial process automation has often relied on traditional machine learning approaches that require large amounts of well-analyzed data. However, in the banking industry, and especially in specific tasks such as processing tax authority claims, data annotation faces significant challenges due to the need for highly skilled professionals and privacy issues. Our work therefore aims to fill the research gap by applying weak observation, a technique that allows the use of imprecise, inconsistent or incomplete data to train models. This is particularly relevant for the banking sector, where data become outdated quickly and often have limited access due to regulatory constraints. Methodologically, to implement the idea of weak supervision, we used the Snorkel framework to create a training dataset using markup functions developed together with Bank Point experts. This allowed us to significantly reduce the dependence on the time-consuming process of manual data markup and to use large volumes of unlabeled documents. The results of the study showed that weak control approaches can significantly improve the efficiency of tax claims processing by creating models capable of classifying and interpreting different types of tax documents with high accuracy. In addition, the application of weak control can accommodate the need for constant updating of data and legislation, making it preferable for the dynamically changing environment of the financial sector. Using weak supervision to automate responses to tax claims not only improves the quality of data processing, but also helps to reduce the workload of specialists, improving the overall efficiency of financial operations. These results could have an impact on the future application of machine learning in the financial sector, given the importance of innovative approaches in data-constrained environments.
Development of an Algorithm of the Formation of IT Project Teams Based on Data from the Digital Footprint of Students
Authors: Melnikova Antonina Vladimirovna , Vorobeva Marina Sergeevna , Egorova Elizaveta Vladimirovna , Chekanova Elizaveta Dmitrievna
Published: August 2024

The article discusses the development of an algorithm for the formation of IT project teams. The materials were data from the digital footprint of IT students. The student's digital footprint is a constantly updated set of data, including accounting documents of project disciplines, intermediate results in disciplines, and practical training. The paper provides an example of solving the problem of forming teams using graphs. An algorithm based on a graph model has been proposed, which allows you to build a graph reflecting the interaction of students in past projects. Commands are formed based on the constructed graph. Two approaches to command formation are proposed inside the graph model: based on vertex clustering and using graph traversal. To determine the best team, a graph of student communication is built with text tags representing technologies, programming languages, frameworks, etc. The algorithm was tested on data from students of the IT department of Mathematical Support and Administration of Information Systems of the School of Computer Science and requirements for a real project and tested on the spontaneous distribution of students on projects within the discipline. Using the algorithm, you can estimate how successful the split was. The creation of effective teams plays a key role in the successful implementation of projects, therefore, the proposed algorithm can be useful for teachers and project managers in the IT field. The developed algorithm is planned to be integrated into the IT project executors search web service.
Use of Genetic Algorithms and Neural Networks in the Analysis of Foot Deformities
Authors: Kireev Sergey Ivanovich , Batraeva Inna Aleksandrovna , Panteleev Dmitry Sergeevich , Zaboev Maxim Vladislavovitch
Published: August 2024

The work is devoted to the current problem of diagnosing foot deformities, which are characterized by a high incidence among all age groups. Among the objective quantitative methods for diagnosing flatfoot, plantography, based on the assessment of prints of the plantar surface of the foot, has become widespread in clinical practice. The purpose of the study was to evaluate and analyze the effectiveness of methods for automatic assessment of footprints using “computer vision”. The study examines methods for automatic recognition and marking of photoplantograms of the foot using genetic algorithms and neural networks to construct control points of the foot using the example of calculating the indices of the longitudinal and transverse arches of the foot. A comparison was made of the results of calculating flatfoot indices and photoplantograms using manual and automatic markings. It was found that the accuracy of automatic methods for analyzing photoplantograms using genetic algorithms and neural networks is 92–97% in relation to manual marking. At the same time, the time spent on manual marking exceeded the duration of automatic image analysis by 2 - 2.5 times. The results obtained confirmed the possibility of optimizing the diagnostic process when conducting mass (screening) examinations of the condition of the arches of the feet.
A Platform for Collecting Dermatoscopic Images of Patients’ Neoplasms
Authors: Kozachok Alexander Vasilevich , Spirin Andrei Andreevich , Eletskiy Kirill Vyacheslavovich , Kozachok Elena Sergeevna
Published: August 2024

The article deals with the formation of a domestic dataset of dermatoscopic images of skin neoplasms of patients, the requirements for metadata and photographs are formed, the existing data sets most popular in the scientific community for building machine learning models for the classification of dermatoscopic images are described. The architecture of the developed platform for data collection of dermatoscopic images of skin neoplasms of patients from the Russian Federation is described.
An Accurate Real-Time Object Tracking Method for Resource Constrained Devices
Authors: Sardaryan Armen , Sahakyan Vardan , Melkonyan Vahagn , Sargsyan Sevak
Published: August 2024

This paper addresses the challenge of single-object tracking on resource-constrained devices, a critical aspect for applications like autonomous drones and robotics. We propose an efficient real-time tracking system that leverages the strengths of transformer-based neural networks in combination with correlation filters. Our research makes several key contributions: first, we conduct a comprehensive analysis of existing object tracking algorithms, identifying their advantages and limitations in resource-constrained environments. Second, we develop a novel hybrid tracking system that seamlessly integrates both neural networks and traditional correlation filters. This hybrid system is designed with a switching mechanism based on perceptual hashing, which allows it to alternate between fast but less accurate correlation filters and slower but more accurate neural network-based algorithms. To validate our approach, we implement and test the system on the Jetson Orin platform, which is representative of edge computing devices commonly used in real-world applications. Our experimental results demonstrate that the proposed system can achieve significant improvements in tracking speed while maintaining high accuracy, thereby making it a viable solution for real-time object tracking on devices with limited computational resources. This work paves the way for more advanced and efficient tracking systems in environments where computational power and energy are at a premium.
Static Memory Allocation for Real-Time Operating Systems
Authors: Zelenova Sofya Anatolyevna ZELENOVA
Published: August 2024

Critical real-time operating system (RTOS) reliability improvement remains to be a relevant and demanding task. The use of detailed requirements provided by the developers introduces new opportunities in this direction through the memory management facilities. In this paper we present a new approach of static memory allocation in real-time systems with robust memory space partitioning. We propose to design a static memory layout tool based on the formal description of the project memory requirements. The proposed formal requirements are platform agnostic and are based only on the needs of the application software. We introduce general concepts, which allow us to use a universal approach for static memory layout tool creation. We also describe the general scheme of the memory layout algorithm as well as the requirements that must be taken into account when each step of the algorithm is implemented. We tested our approach on real industrial projects and confirmed its versatility, adaptability and effectiveness.
Declarative Approach to Virtual Machine Introspection
Authors: Stepanov Vladislav Mikhailovich , Dovgalyuk Pavel Mikhailovich , Fursova Natalia Igorevna
Published: August 2024

The prominent problem in memory dump analysis and virtual machine introspection approaches is a semantic gap. Availability of debug symbols or knowledge about kernel data structures offsets is very important for retrieving high-level information from binary code. A set of information about kernel data structures field offsets is called an OS profile. Methods of generating such profiles are based on guest agents, debug symbols, source code compilation or binary analysis. Using only binary analysis makes it possible to do research with a minimal knowledge about analyzed guest OS. In this paper we present a novel approach for OS profile generating. It is based on system call tracing and comparison between data obtained from application binary interface and data extracted from expected locations of kernel structures. The advantage of this solution is scalability for supporting different guest systems. While other existing approaches use heuristics based on handling Linux kernel functions that access the fields, the current approach suggests using heuristics that are similar across different OS families. We also suggest a method of describing heuristic algorithms for profile generation that simplifies understanding of them and makes them more resistant to changes between OS versions.
Culture and Ascetic Protestantism
Authors: Zafirovski Milan
Published: August 2024

The article examines the relationship between cultural phenomena and the emergence and expansion of ascetic Protestantism. More specifically, it explores the cultural roots and conditions of original, early Calvinism, as distinguished from its own influences and ramifications in culture and society in general mostly emphasized in the current sociological literature. Calvinism is therefore treated not only as a conditioning and explanatory factor in cultural and other social respects, as largely done in the literature, but also as a culturally and socially overall conditioned and explained variable. This article posits and shows that the overarching and cardinal cultural root and condition of orthodox Calvinism is pre-modern medieval irrationalism, including religious and related superstitions and fanaticism. It therefore rediscovers Calvinism in the new light (or rather darkness) of being originally the effect and subsequently the system of perpetuation of medieval cultural irrationalism, in particular religious superstition and fanaticism. The intent of this article is to contribute to a better understanding, explication, and prediction of the cultural and related social causes and effects of Calvinism in the sociological literature.
The Public’s Response to the Book of Mormon
Authors: A’Hearn Casey Logan
Published: August 2024

When the Book of Mormon was published in March 1830, it represented a textual shift from the Bible as the representation of sole scriptural truth to the possibility of the Book of Mormon as an equal contender. Within the New York newspaper scene, the Book of Mormon was constructed as a novel false scripture as well as a true culmination of prophecy by competing parties. Within these parties, social actors presented interesting rhetorical dynamics between the establishment of authority and competing Christian canons. Both parties use scripture – the Bible and the Book of Mormon – as tools to navigate the world. One party uses the Bible to argue that the Book of Mormon stands in opposition to an established Christian canon. The other argues that the Book of Mormon is a fulfilment of prophecy made necessary by the Bible. This paper explores the clash of authoritative discourses between those who understood the Book of Mormon as scripture and those who did not. Nevertheless, both groups insist on taking “scripture” seriously. Reading the archive with critical phenomenology, I argue that the publication of the Book of Mormon represents a historical moment where the identity formations of nineteenth-century Americans relied on a discourse of authority mediated through competing canons.
Constructed Rivalry
Authors: Kearney Jonathan
Published: August 2024

The majority of contemporary critical editions of the text of Hebrew Bible are based on one of two mediaeval manuscripts: the Aleppo Codex and the Leningrad Codex. Various claims have been made on the relative merits of each of these two codices. While these claims are often grounded in the language of textual criticism, there is a good deal more at play. The two codices have come to be constructed by some as oppositional artefacts. This article seeks to better understand this constructed rivalry by utilizing Watts’ conception of the relic text. It is proposed that the status of the Aleppo Codex as just such as relic text has been enhanced by diminishing the status of the Leningrad Codex. This oppositional relationship has been utilized by the state of Israel which currently houses the Aleppo Codex in the Israel Museum to enhance its status as the custodian of Jewish material culture.
Marilynne Robinson, Reading Genesis. London: Virago (2024)
Authors: Anderson Bradford A
Published: August 2024

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New Physics in the 3-3-1 models
Authors: Long Hoang Ngoc
Published: August 2024

The fundamental basics of the Standard Model such as local gauge symmetry and mass generation via the Higgs mechanism are widely confirmed by current experimental data. However, some problems such as neutrino masses,
dark matter, baryon asymmetry of Universe have clearly indicated that the Standard Model cannot be the ultimate theory of Nature. To surpass the mentioned puzzles, many extensions of the Standard Model (called beyond Standard Model) have been proposed. Among beyond Standard Models, the 3-3-1 models have some intriguing features and they get wide attention. The pioneer models develop in some directions. In this paper, some versions of the 3-3-1 models and new consequences are presented.
Perceived psychosocial effects of COVID-19 on the teaching realities of Foundation Phase educators in selected rural quintiles 1 to 3 schools in South Africa
Authors: Mtande Nozipho , Ross Eleanor
Published: August 2024

The COVID-19 pandemic severely disrupted schooling, not only in South Africa, but globally. In the study reported on here we investigated the perceived psychosocial effects of the pandemic on the teaching realities of Foundation Phase (FP) educators in rural quintiles 1 to 3 schools in the North West province, South Africa. A qualitative, case study design was adopted with 10 educators purposively selected from 3 schools to participate through telephonic interviews. The findings reveal that as educators contended with the new rotational method of school attendance, challenges of limited teaching time, curriculum coverage, learner absenteeism and the lack of parental support that negatively affected their overall state of psychosocial well-being. This state of well-being was characterised by high stress levels, feelings of hopelessness, anxiety and a lack of accomplishment for educators. Despite these experiences, some educators demonstrated agency and resilience in ensuring that they carried out their core responsibility of teaching, but perceived themselves as requiring psychosocial support. The conclusion reached is that the available support structures provided by the Department of Basic Education appeared to be under-utilised and there was a critical need to introduce and advocate for mental health interventions to support educators emotionally.
Educators’ adaptive assessment procedures in teaching English First Additional Language in Grade 6 inclusive classrooms in South Africa
Authors: Chauke Margaret , Tabane Ramodungoane
Published: August 2024

Primary school educators in South Africa often experience difficulties in applying recommended adaptive assessment methods in large multilingual classes, with these challenges being exacerbated when teaching and assessing English as First Additional Language (EFAL). In this article, we report on a study that explored Grade 6 educators’ knowledge and use of adaptive assessment methods when teaching EFAL. The national Policy on Screening, Identification, Assessment and Support ([SIAS] Department of Basic Education [DBE], Republic of South Africa [RSA], 2014) underpins our study as a theoretical framework. We followed a qualitative research approach to examine the knowledge as well as the classroom practices of 6 purposively selected educators who taught EFAL. The study was grounded in the interpretivist paradigm and investigated educators’ lived experiences integrating adaptive assessment procedures into the teaching of EFAL in Grade 6 inclusive classrooms. We relied on semi-structured interviews, observation, and document analysis to collect data and performed thematic analysis to identify, analyse and report repeated patterns. The findings from our study indicate that the participating educators perceived their training in inclusive education and their use of adaptive assessment methods as inadequate, especially in the context of large, under-resourced classrooms. As a result, we recommend that educators should receive the necessary support from the school-based support teams and the district-based support teams to use adaptive assessment methods when teaching EFAL.
Wiceprezes Rady Ministrów jako członek Rady Ministrów
Authors:   Uniwersytet Warmińsko-Mazurski w Olsztynie, Juchniewicz Joanna
Published: August 2024

The Vice-Presidents are optional members of the Council of Ministers. Their appointment to the government depends on the Prime Minister and also on coalition arrangements. Under the 1997 Constitution, there was no uniform model for the appointment of deputy presidents of the Council of MinistersThe vice-presidents do not have any independent powers. Pursuant to Article 6 of the Act on the Council of Ministers, the Deputy Prime Minister may direct the work of the Cabinet in the event of the absence or temporary inability of the Prime Minister to perform his/her duties. The vice-president performs the tasks and competences within the scope entrusted to and on behalf of the Prime Minister. In the context of membership of the Council of Ministers, their position is equivalent to that of the other members of the government, and to an analogous extent they have duties and may exercise rights.
Kategoria „legitymizacji” w orzecznictwie Trybunału Konstytucyjnego – konstrukcyjne uwarunkowania znaczeniowe
Authors:   Uniwersytet Szczeciński, Nowotko Paweł
Published: August 2024

This paper aims to analyze the Constitutional Tribunal’s (CT) jurisprudence regarding the term “legitimation” to reconstruct its definition and compare it with its lexical meaning. Despite its varied use across multiple contexts, the jurisprudence lacks a uniform definition of legitimation. This situation necessitates reliance on diverse semantic intuitions. A doctrinal-legal method combined with logical-linguistic analysis was employed, analyzing 100 CT rulings that used the term “legitimation”. The CT’s jurisprudence shows that the application of the term is not limited to legal legitimacy but also includes broader contexts such as social perception, alignment with the values of the legal system, or the sovereign’s will. It is used in contexts that align with previous lexical findings, suggesting that legitimation can be viewed both as a state and a process. The analysis confirms the need for a terminological distinction, which could help organize discourse around this concept.
Znamiona przestępstw w świetle Konstytucji Rzeczypospolitej Polskiej
Authors:   Prokuratura Rejonowa w Pszczynie, Knaga Daniel
Published: August 2024

The article discusses the role of constitutional principles in the process of constructing and assessing the characteristics of crimes in a democratic state ruled by law. In particular, the text discusses the essence of the features of a prohibited act and indicates the scope of criminal liability under Art. 42 section 1 of the Constitution of the Republic of Poland and describes the impact of the principle of nullum crimen sine lege and the principle of proportionality on the issue of the characteristics of crimes. The conclusions drawn from this analysis may become an indication for the legislator on how to construct the elements of prohibited acts so that these regulations are consistent with the Constitution of the Republic of Poland. These features constitute the basis for the accusation and also set the limits of the activities of law enforcement agencies. Their role in protecting legal order is therefore invaluable.
System of Government in Poland after the Country’s Accession to the European Union
Authors:   University of Warmia and Mazury in Olsztyn, Tomaszewski Waldemar
Published: August 2024

The subject of research presented in the article is the system of government in Poland. The considerations concern the relationship between the normative solutions defined in the Constitution of the Republic of Poland of 1997 and the influence of the EU on the modification of political solutions in Poland. It was hypothesized that after Poland’s accession to the EU, the system of government in Poland changed in terms of political practice. It has been shown that functioning in the EU resulted in a departure from the characteristic rationalization of the system of government and brought it closer to the parliamentary model. The research was based on the following methods: institutional-law, systemic and comparative.
The Fourth Amendment to the Constitution of the United States of America in the Light of the European Union Data Protection Model
Authors:   University of Wroclaw, Kuznicka-Blaszkowska Dominika
Published: August 2024

The question of adequacy of data protection model in the United States is one of the most important in transatlantic business and politic relations. The fact that European Commission’s decisions recognizing the adequacy have been annulled twice put relations between EU and US in very difficult phase. In this article I aim to analyse whether basis guarantees for privacy protection in the United States in the shape of the Fourth Amendment to the US Constitution are adequate in the meaning of data protection model in EU. By looking at the practice of interpreting of the Fourth Amendment and art. 8 of European Convention of Human Rights, in line with police directive and GDPR I try to answer the questions if the Fourth Amendment protection gives enough guarantees to ensure respect towards privacy and data protection rights of individuals.
Comparative characteristics of patients with a combination of obstructive sleep apnea and paroxysmal atrial fibrillation in the groups of interventional and conservative treatment of arrhythmia
Authors: Obukhova N. T. , Agaltsov M. V. , Drapkina O. M.
Published: August 2024

Aim. To compare the clinical characteristics of two groups of patients with a combination of obstructive sleep apnea (OSA) and paroxysmal atrial fibrillation (AF), undergoing conservative treatment for arrhythmia and after pulmonary vein isolation.

Material and methods. The study included 362 patients with paroxysmal AF who underwent respiratory sleep monitoring.

Results. A predominance of clinically significant OSA was revealed (moderate and severe — 37% and 29%, respectively), as well as a higher drug burden and comorbidity in the group of patients receiving drug treatment for AF. The threshold value of body mass index (BMI), at which a high risk of severe OSA was predicted, corresponded to class 1 obesity (BMI ≥31 kg/m2). The results obtained demonstrated an association between an increase in the left atrium anteroposterior size and the severity of OSA (4,1 [3,8-4,4] cm, r=0,28; p<0,001), which may be due to cardiac structural remodeling in patients with a combination of paroxysmal AF and severe OSA.

Conclusion. In a cohort of patients with paroxysmal AF, a high incidence of clinically significant OSA was revealed. In the group of patients with a combination of OSA and AF undergoing conservative treatment, more unfavorable cardiovascular characteristics and a more severe comorbid status were revealed compared to the group of patients undergoing surgical treatment.
Relationship between the white blood cell count and some lipid profile parameters in cancer patients with myocardial infarction
Authors: Skorodumova E. G. , Skorodumova E. A. , Kostenko V. A. , Siverina A. V.
Published: August 2024

Hokkaido University (Tsumita T, 2022) researchers found that endothelial cells accumulate low-density lipoproteins (LDL) in tumor blood vessels. At the same time, the endothelium carries out neutrophil chemotaxis, which perform an immunosuppressive function contributing to cancer progression.

Aim. To search for the relationship between the white blood cell (WBC) count and some lipid profile parameters in cancer patients with myocardial infarction (MI).

Material and methods. We examined 319 patients who were treated at Dzhanelidze Research Institute of Emergency Medicine in 2018-2023, which were divided into three groups: MI in combination with an active cancer — 132 patients (Group I), MI+cancer in history — 58 patients (Group II), MI without cancer — 129 patients (Group III). Following laboratory data used in routine practice were assessed: WBC count, relative neutrophil count, total cholesterol, low-density lipoproteins.

Results. Cancer patients with MI are characterized by higher WBC and neutrophil count than in other samples However, the total cholesterol level was significantly lower in this sample, and the LDL level was not significantly different. Patients with MI and previous cancer occupied an intermediate position between groups I and III in terms of studied parameters.

Conclusion. In general, data on the role of cholesterol levels in cancer patients are contradictory. In particular, some studies have shown that elevated cholesterol levels are a potential risk factor for cancer. In our study, as in a number of others, no significant associations were identified between elevated cholesterol levels and the presence of cancer. Our study is a step towards understanding the connection between the cholesterol concentration and the immune response in cancer patients with MI.
Standart MIMIC ve Arınık Çapa Maddeli MIMIC Yöntemleriyle Gerçekleştirilen DMF Çalışması
Authors: Tamcı Pelin , Kelecioğlu Hülya
Published: August 2024

Bu çalışmanın amacı değişen madde fonksiyonu (DMF) belirleme yöntemlerinden standart MIMIC (M-ST) ve arınık çapa maddeli MIMIC (M-AÇM) yöntemlerinin benzerlik ve farklılıklarını belirlemektir. Araştırma PISA 2012 verileri ile 900 ve 450 kişilik örneklemler üzerinde referans-odak grup oranları 550/350, 450/450, 300/150, 225/225 olacak şekilde yürütülmüştür. M-ST ve M-AÇM yöntemleri ile belirlenen DMF’li maddeler karşılaştırıldığında, tüm koşullarda M-AÇM yöntemiyle daha az sayıda DMF’li madde belirlendiği görülmüştür. 26 nolu maddenin tüm koşullarda her iki DMF belirleme yöntemiyle de DMF gösterdiği belirlenmiştir. En çok DMF’li madde sayısının M-ST yönteminde 900 kişilik örneklem büyüklüğü için referans-odak oranı 550/350 olduğunda ortaya çıktığı görülmüştür.
Paisagem, Território e Cultura: Estudo de caso do grupo de dança de Siriri Flor de Atalaia
Authors: Paula Nátali de , Gulinelli Érica Lemos , Benini Sandra Medina
Published: August 2024

This article investigates the intersection between traditional cultural practices and the urban landscape, focusing on the cultural manifestations of Siriri and Cururu in the city of Cuiabá, Mato Grosso. The study highlights how these dance forms not only reflect but also shape the city's cultural and physical landscape, integrating in meaningful ways with urban life and local cultural heritage. The research specifically addresses the influence of these practices in public and free space, particularly in the courtyards used by the dance group Siriri Flor de Atalaia, which serve as vital stages for rehearsals and cultural presentations. The primary objective of this study is to analyze the transformations in the landscape of open spaces caused by the continuous interaction between the Siriri Flor de Atalaia group and its urban environment. This analysis seeks to understand how these spaces are used for the practice and dissemination of Siriri and Cururu culture, and how they contribute to the cultural dynamics of the city of Cuiabá. Through a detailed examination of physical and cultural changes in these places, the article explores the role of backyards and open spaces in perpetuating popular culture and forming a strong local identity. Methodologically, the study is based on a bibliographical review that addresses the themes of territory, open spaces, landscape and culture of the Siriri and Cururu dance. In addition, a case study of the courtyard of the dance group Siriri Flor de Atalaia is carried out, using direct observation and qualitative analyzes to capture the essence of cultural interactions and their impact on urban space. The results of the article provide an in-depth analysis of the cultural landscape formed around the Siriri Flor de Atalaia group, revealing how practice spaces not only serve as places for cultural activities, but also as elements that redefine the urban landscape. This investigation contributes significantly to debates about the importance of preserving and promoting cultural spaces within the urban environment, supporting the continuity of popular culture and informing public policies that value and promote traditional cultural practices in the city of Cuiabá. This study emphasizes the need for a more integrated and conscious approach to urban planning, which considers cultural practices as essential components of city development, not only for the preservation of heritage, but also as a vital strategy for enriching community life and strengthening local identity.
Automated Control and Delivery System for Science Practical Instructions to Public Schools
Authors: Jinadu Afeez
Published: August 2024

Background. The dispatch of practical instructions to schools and supervisors before the actual conduct of the practical examination over the years has not received the same level of attention as given to the movements of people and goods and, therefore, is prone to challenges. However, the process could be automated using artificial intelligence. Previous studies have investigated the effects of automation on the control and delivery of goods in the transport management sector. 
Objectives. This study assessed science teachers’ challenges and readiness for automated practical instruction control and delivery systems. 
Materials and methods. The study adopted an ex post facto design and recruited one hundred science teachers. Science Teacher Readiness for Automated Practical Instruction Control and Delivery (r = 0.83) was used to collect data, which were analysed descriptively. 
Results. There are more male (73%) science teachers than female (27%). 84% of the respondents listed cost as one of the challenges, and 83% indicated resistance to change and technical difficulties, ethical issues (67%), and integration with the existing system (65%). The science teachers are moderately ready (64%). In comparison, 24% are lowly ready, and 12% are highly prepared to deploy an automated practical instruction control and delivery system. 
Conclusion. Automation for delivering practical science instructions has more significant benefits than the manual method; however, science teachers are ready for its deployment despite its challenges. Therefore, efforts should be geared towards overcoming the inherent difficulties so that the benefits can be thoroughly enjoyed.
Improvement of the functional layouts of multifunctional soil-cultivating sowing units
Authors: Belts Alexey F. , Guzenko Kirill E.
Published: August 2024

BACKGROUND: With the technology evolution, the use of combined machines and units has become more in demand. From the numerous studies that were carried out during the operation of machines of this type, it can be seen that the cost of raw materials and financial costs have been significantly reduced, and the number of other advantages has been identified as well.
AIM: Improvement of the functional layouts of multifunctional tillage sowing units for a more optimal combination of structural layouts and parameters of its use.
METHODS: Engineers use the method of changing working bodies designed as layouts aiming to turn the machines into the modules capable of performing various types of operations based on working conditions. Thanks to this method, sets of individual working bodies and combinations are prepared for any kind of conditions (soil, climate, etc.).
In addition to the advantages, this system has a number of disadvantages. One of these is that at the factory-built modules that are part of the original basis of the unit cannot be fully adapted to environmental conditions and economic factors of production. In this regard, combination of structural layouts and selection of the necessary parameters become problem causing. It is difficult to choose necessary parameters that are capable of ensuring minimal losses and adjusting the unit to the necessary operating mode.
The objects of study are the devices and production processes, the main task of which is performing tillage and sowing operations. The practical value of this study presented in the form of:

building the algorithm capable of structuring the analysis and synthesis of the structural layout of the tillage-sowing unit to find the working links for various types of unit functions;
finding the methods and improved combinations of working bodies, comparison of similar mechanical analogues with the original properties of systems.

RESULTS: When studying the studies of Wilde, who gave a description of the combined units, as well as the studies of Runchev, who determined the generalization of the combined machines, the relevant typology of agricultural machinery was developed. In this typology, one of the most important characteristics is multifunctionality, which has developed from the need for the versatility of units and the compilation of combinations of several units. The developed technology contains a number of characteristics that are fundamental for the choice of agricultural machinery.
CONCLUSION: As a result of the study, it was determined at which velocity of the unit the system is balanced.
Evaluation of usefulness of pleural fluid/serum alkaline phosphatase in the diagnosis of tubercular pleural effusion
Authors: Quadry Shafiul Azam , Dip Abir Hasan , Dhar Uma , Shariful Alam M. , Tanimul Haque Rijvy M. , Zakir Hossain Sarkar M. , Sayedul Islam M. , Masud Abdullah Al , Shohidul Islam M. , Rowshan Arif M.
Published: August 2024

Background: Tuberculosis (TB) remains a common cause of pleural effusions, diagnosed by detecting Mycobacterium tuberculosis in pleural fluid or biopsy specimens through microscopy, culture, or histological demonstration of caseating granulomas and acid-fast bacilli (AFB). In high-burden settings, the diagnosis is frequently inferred. Objective was to assess the usefulness of pleural fluid/serum alkaline phosphatase in the diagnosis of tubercular pleural effusion.
Methods: This cross-sectional observational study took place at the department of respiratory medicine, NIDCH, Dhaka, from December 2018 to December 2019. Seventy new cases of pleural effusion meeting specific criteria were enrolled with informed consent obtained. Diagnostic assessments included Gene Xpert, cytology, culture and sensitivity testing, biochemical analyses, and alkaline phosphatase testing on pleural fluid and blood samples. Closed needle pleural biopsies using an Abrams needle were performed for histopathological examination. Data analysis was carried out using SPSS version.
Results: In this study of 70 patients, mean age 48.67±17.99 years (range: 17-83 years), with 42.9% aged 51-70 years, males predominated (6:1). Histopathology showed TB in 45.7%. TB patients had lower neutrophil and platelet counts, lower serum alkaline phosphatase, higher ESR, and higher pleural fluid alkaline phosphatase and P/S ALP ratio. The P/S ALP ratio had an AUC of 0.881 (95% CI 0.798-0.964), with a cut-off of 0.49, sensitivity/NPV of 93.8%, and specificity/PPV of 78.9% for diagnosing TB pleural effusion.
Conclusions: The pleural fluid/serum alkaline phosphatase ratio is a valuable diagnostic tool for tuberculous pleural effusion. Further validation through a multicenter randomized trial with a larger sample size is recommended.
A clinicopathological evaluation on thrombocytosis in correlation with platelet indices in a tertiary care hospital: a retrospective study
Authors: K. S. Muhammed Safwan , K. M. Prajna , Ullas Chaithanya
Published: August 2024

Background: Thrombocytosis refers to platelet count >450×109/l in the peripheral blood. It is classified into primary and secondary forms. An increased platelet count has emerged as a significant clinical issue for the differential diagnosis of numerous physiological and pathological conditions. This study was done to evaluate the clinical study on patients with thrombocytosis in correlation with platelet indices.
Methods: This was a retrospective study which included 105 subjects. EDTA samples were collected from thrombocytosis patients for the estimations of platelet indices. The severity of thrombocytosis was grouped as Mild, Moderate, Severe and Extreme. The results were analysed using SPSS Software.
Results: Commonly encountered etiological findings were secondary thrombocytosis (97.14%). Correlation in between the various platelet indices, the PCT was positively correlated with PLT count as well as MPV, and the PDW was positively correlated with MPV as well as PCT. According to the severity of thrombocytosis, significant difference was observed with PLT count and PCT, no statistical significance was observed in MPV or PDW.
Conclusions: The study found that secondary thrombocytosis was the main etiological factor for thrombocytosis, which is primarily driven by respiratory tract infections, gastrointestinal tract infections, urinary tract infections, and other infections (bacterial infections and viral infections). Platelet indices such as PLT count and PCT showed statistical significance with the severity of thrombocytosis and no statistical significance in MPV and PDW.
Impact of obesity on atherogenic index in young adult females in Gadag, Karnataka
Authors: M. Margaret Mary , M. K. Jayalakshmi
Published: August 2024

Background: Obesity is one of the most blatantly apparent, yet most disregarded, public health challenges in the present times. The prevalence of abdominal obesity in India was resolved to be 40% in females in India in the NFHS 5 survey. The gynaecological and reproductive fitness of women living with obesity is significant with changes demanded for precautionary health screenings. Obesity is a significant hazard factor for and contributor to accelerated morbidity and mortality, originally from cardiovascular complications and metabolic disorders. The rise in cardiovascular events has demanded the identification of practicable predictors that can assist in foretelling atherogenicity.
Methods: This cross-sectional study was done between May 2022 to April 2024, in Gadag Institute of Medical Sciences, Gadag which comprised 240 female participants between the age of 18-40 years who were overweight/obese. Anthropometric parameters were measured and serum levels of lipid profile parameters were analysed Atherogenic Index was calculated.
Results: Fat mass showed the strongest correlation with atherogenic index (r = 0.261), followed by fat mass index (r = 0. 257), BMI (r = 0.167) and body fat index (0.141). Free fat mass showed the least correlation (r = -0.074).
Conclusions: Obesity and raised anthropometric parameters lead to an unfavourable lipid profile pattern and raises values of the atherogenic index.