bluuebunny/crossref_metadata_2025 huggingface dataset:
Auditoria em Saúde na Realidade Hospitalar / Health Audit in the Hospital Reality
Authors: Evangelista André Tavares , Bezerra Martha Maria Macedo
Published: March 2021

Resumo: A auditoria em saúde na dinâmica de serviços, projetos, contratos, pactuações e ações na qualidade da assistência prestada ao paciente tornou-se uma ferramenta de gestão de relevância nas instituições de saúde de todo o Brasil. Este artigo tem como objetivo geral a descrição do trabalho de auditoria existente no Hospital e casa de saúde de Russas – HCSR e, como objetivos específicos, a identificação das mudanças ocorridas nesta instituição de saúde após a chegada do auditor, e a descrição dos atributos do profissional de auditoria. A metodologia utilizada na investigação é do tipo exploratório descritiva, com abordagem qualitativa. Os dados foram coletados por meio de entrevista semiestruturada e descritos de modo a compor o perfil do auditor e delinear o trabalho de auditoria realizado no HC$R. A análise dos dados revelou que a auditoria em saúde no hospital investigado é desenvolvida por profissionais especializados na área, e que a presença do auditor em uma instituição de saúde é imprescindível para a melhoria de sua gestão e para a eficácia dos serviços prestados à população. Quanto aos atributos do auditor em saúde, a pesquisa revelou o bom senso, a imparcialidade, o sigilo, a presteza e o comprometimento com a exatidão das informações e, acima de tudo, o elevado conhecimento técnico com que os auditores entrevistados desenvolvem suas ações. No que concerne às opiniões dos entrevistados quanto à condução de suas atribuições na auditoria em saúde, foram evidenciados os vários beneficies deste serviço para a instituição observada, em oposição aos poucos obstáculos existentes no desenvolvimento de seu trabalho.
A Importância do Planejamento de Capacidade para a Atividade Industrial / The Importance of Capacity Planning for Industrial Activity
Authors: Sousa Josiano Cesar de , Silva Liandra Costa , Rodrigues Maikon Gomes
Published: March 2021

Resumo: O presente trabalho faz uma abordagem acerca do planejamento de capacidade produtiva nas organizações industriais, com o intuito de apontar o objetivo e a importância dessa ferramenta, bem como suas possíveis vantagens e desvantagens. A problemática da pesquisa levantada é: como a aplicação do Planejamento de Capacidade Produtiva pode interferir no faturamento de organizações industriais? O estudo foi realizado de forma qualitativa, a partir da metodologia de revisão bibliográfica em periódicos. Nesse sentido, utilizamos diversos artigos científicos referentes a essa temática para evidenciar, de forma embasada, impactos decorrentes da aplicação dessa ferramenta. Como resultado observou-se que o planejamento de capacidade é essencial para prever e deter perdas na produção industrial, uma vez que, examina o ambiente interno e externo, considerando múltiplos fatores como demanda, mão de obra, maquinário, estoque, entre outros elementos que contribuem de forma direta no desempenho e consequentemente no faturamento da organização.
DETERMINATION AND CHARACTERIZATION OF CAFFEINE CONTENT OF SMALL AND LARGE SIZE COFFEE BEANS IN SIDAMA AND KAMBATA TAMBARO ZONES SOUTHERN, ETHIOPIA USING UV-VIS SPECTROPHOTOMETER
Authors: Dado Tsegaye Bojago
Published: March 2021

In this study work using UV/vis spectrophotometer, the caffeine determination and comparison, as well as characterization of caffeine from small and large size roasted coffee by molar decadic absorption coefficient of pure caffeine were studied. The molar decadic absorption coefficient of pure caffeine in water, wavelength at 272.5nm and dichloromethane at275nm were 27.73 and respectively.
Smoking, Genetic Predisposition, and Colorectal Cancer Risk
Authors: Chen Xuechen , Jansen Lina , Guo Feng , Hoffmeister Michael , Chang-Claude Jenny , Brenner Hermann
Published: March 2021

INTRODUCTION:

Smoking and genetic predisposition are established risk factors for colorectal cancer (CRC). We aimed to assess and compare their individual and joint impact on CRC risk using the novel approach of genetic risk equivalent (GRE).

METHODS:

Data were extracted from the Darmkrebs: Chancen der Verhütung durch Screening study, a large population-based case-control study in Germany. A polygenic risk score (PRS) based on 140 CRC-related single nucleotide polymorphisms was derived to quantify genetic risk. Multiple logistic regression was used to estimate the individual and joint impact of smoking and PRS on CRC risk, and to quantify the smoking effect in terms of GRE, the corresponding effect conveyed by a defined difference in PRS percentiles.

RESULTS:

There were 5,086 patients with CRC and 4,120 controls included. Current smokers had a 48% higher risk of CRC than never smokers (adjusted odds ratio 1.48, 95% confidence interval 1.27–1.72). A PRS above the 90th percentile was significantly associated with a 3.6-, 4.3-, and 6.4-fold increased risk of CRC in never, former, and current smokers, respectively, when compared with a PRS below the 10th percentile in never smokers. The interaction between smoking and PRS on CRC risk did not reach statistical significance (P = 0.53). The effect of smoking was equivalent to the effect of having a 30 percentile higher level of PRS (GRE 30, 95% confidence interval 18–42).

DISCUSSION:

Both smoking and the PRS carry essentially independent CRC risk information, and their joint consideration provides powerful risk stratification. Abstinence from smoking can compensate for a substantial proportion of genetically determined CRC risk.
Rebounds und Wirtschaftswachstum
Authors: Lange Steffen , Berner Anne
Published: March 2021

Rebound-Mechanismen tragen dazu bei, dass Umweltziele nicht erreicht werden. Gleichzeitig gehen sie mit Wirtschaftswachstum einher. Bedeutet dies, dass wir mit weniger Wachstum leben müssen, um Rebound-Effekte zu verhindern und damit Umweltziele zu erreichen?
Gestaltung einer Balanced Scorecard nach den Prinzipien der Gemeinwohl-Ökonomie
Authors: Gehra Wolfgang , Kiermeier Darryl
Published: March 2021

Kann eine Balanced Scorecard nach den Prinzipien der Gemeinwohl-Ökonomie gestaltet werden? Wie können die Inhalte der Gemeinwohl-Ökonomie in Form strategischer Ziele Teil einer Balanced Scorecard sein? Ein innovatives Modell zeigt vielversprechende Ansätze für eine Anwendung in der Praxis auf.
First record of Dittrichia graveolens (Asteraceae, Inuleae) in Chile
Authors: Santilli Ludovica , Lavandero Nicolás , Montes Orlando , Lustenhouwer Nicky
Published: March 2021

Dittrichia graveolens is reported for the first time for the flora of Chile and for the Southern Cone. A brief description as well as illustrative pictures of the species and the habitat are provided. Furthermore, we present a map of the site where the population was found and a short key to the species of Dittrichia present in Chile. Insights about its potential invasiveness are discussed.
Reaction of Pentaphenylphosphorus with Hexachloroplatinic Acid
Authors:   South Ural State University, Chelyabinsk, Russian Federation, Zykova A.R.
Published: March 2021

Tetraphenylphosphonium hexachloroplatinate (1) was synthesized by the interaction of pentaphenylphosphorus with hexachloroplatinic acid in acetone. The recrystallization of complex 1 from dimethylsulfoxide gave tetraphenylphosphonium dimethylsulfoxidopentachloroplatinate (2). The compounds have been characterized by IR-spectroscopy and X-ray analysis. The absorption bands characterizing stretching vibrations of the phenyl groups are present in the IR spectra, recorded on a Shimadzu IRAffinity-1S Fourier spectrometer in the 4000–400 cm–1 area in KBr pellets. According to the X-ray analysis, the compound unit cell parameters are: triclinic syngony, space group (1, 2), а = 10.205(10), b = 10.970(15), c = 12.160(11) Å (1), а = 7.7667(4), b = 13.3069(7), c = 14.2562(7) Å (2), a = 73,65(4)°, β = 80.64(3)°, g = 77.48° (1), a = 80.972(4)°, β = 88.205(4)°, g = 89.199(4)° (2), V = 1272(2) Å3 (1), 1454.38(13) Å3 (2). The crystals of complexes 1 and 2 consist of the tetrahedral tetraphenylphosphonium cations and octahedral anions. In cations the phosphorus atoms have a slightly distorted tetrahedral environment (the CPC angles are 107.8(3)-113.2(3)° (1), 105.9(3)–112.9(3)° (2), the P-C distance is 1.785(6)-1.805(6) Å (1), 1.783(7)–1.791(6) Å (2). Platinum atoms in the anions of complexes 1 and 2 are hexacoordinated. In complex 2 the dimethyl sulfoxide ligand is coordinated with the Pt atom via the sulfur atom 2.290(2) Å. Complete tables of coordinates of atoms, bond lengths and valence angles are deposited at the Cambridge Structural Data (CCDC 1865783, 829586 http://www.ccdc.cam.ac.uk).
Synthesis of 5-Phenyl-(5,6-Diphenyl-)-2,3-Dihydro-1,2,4-Triazine-3-Thions and Investigation of Their Reactions with 1,2-Dibromoethane
Authors:   South Ural State University, Chelyabinsk, Russian Federation, Rybakova A.V. , Kim D.G.
Published: March 2021

5-Phenyl-(5,6-diphenyl-)-1,2,4-triazine-3(2H)-thions (1,2) were synthesized by condensation of phenylglyoxal monohydrate with thiosemicarbazide and benzyl with thiosemicarbazide hydrochloride, respectively. Phenylglyoxal monohydrate was obtained by oxidation of acetophenone with selenous acid by the Riley reaction, while benzyl (1,2-diphenylethane-1,2-dione) waw obtained by oxidation of (2-hydroxy-1,2-diphenylethanone) benzoin with nitric acid by the known procedure. The compounds 1 and 2 were studied in reactions with 1,2-dibromoethane in various ratios. The interaction of triazinethione 1 with 1,2-dibromoethane in molar ratios of 1:1 and 1:2 led to the formation of a previously unknown 3-[(2-bromoethyl)sulfanyl]-5-phenyl-1,2,4-triazine (3а). Using a double excess of 1,2-dibromoethane increased the yield of compound 3а by 11 %. The interaction of triazinethione 2 with 1,2-dibromoethane in molar ratios 1:1 and 2:1 led to the formation of 3-[(2-bromoethyl)sulfanyl]-5,6-diphenyl-1,2,4-triazine (3b). In the 1H NMR spectra of compounds 3a,b there are signals of aromatic ring protons in the region of 7.23-8.81 ppm, a triplet of protons of the SCH2 group at 3.22 and 4.06 ppm, and a triplet of protons of the CH2Br group at 4.39 and 5.28 ppm. It is of interest that1,2-bis-(5-phenyl-[1,2,4]triazinyl-3-sulfanyl)-ethane is formed in the case of the reaction of compound 1 with 1,2-dibromoethane in the 2:1 ratio of reagents. In the 1H NMR spectra of the latter, in contrast to the spectrum of compound 3a, there is a signal of the S-CH2 group protons, which are equivalent in this structure and form a singlet at 3.79 ppm. Compound 3a was also studied by chromatography-mass spectrometry (direct sample insertion). It should be noted that under the conditions of mass spectrum imaging, the bromine atom is split off and the mass spectrum shows a peak with m/z 216 with an intensity of 38% and no peak of the molecular ion. The peak with the maximum intensity (m/z 116, 100 %) seems to correspond to 4-thia-6,7-diaza-1-azoniumbicyclo[3.2.0]hept-1(5)-ene. Its high intensity is due to the fact that the structure of the 1,2-dihydrotriazetium cation is aromatic.
Nilai LC50 Cymbopogon nardus L terhadap Musca domestica
Authors: Susilawati Susilawati , Salbiah Salbiah , Fathmawati Fathmawati
Published: March 2021

Latar belakang: Pengendalian serangga umumnya dilakukan menggunakan bahan kimia yang dapat mengancam kesehatan manusia dan lingkungan. Pemanfaatan tanaman sebagai insektisida alami perlu dikembangkan. Cymbopogon citratus diketahui mengandung zat-zat yang berpotensi sebagai insektisida. Penelitian ini bertujuan untuk mengetahui nilai LC50 formulasi Cymbopogon citratus terhadap M. domestica. Metode: Penelitian ini merupakan penelitian kuasi eksperimental. Formulasi dilakukan dengan mengekstraksi Cymbopogon citratus menggunakan methanol dan mengevaporasinya. Aplikasi formulasi dengan mengencerkan ekstrak Cymbopogon citratus menggunakan aquades dengan konsentrasi 20%, 25%, 30% dan 35%. Lalat rumah (M. domestica) yang digunakan adalah lalat dewasa yang ditangkap ke dalam Flytrap dengan diberikan umpan dan dimasukkan ke kandang uji yang  berukuran 30x30x30 cm3. Perbedaan persentase kematian diuji dengan oneway ANOVA dan nilai LC 50 ditentukan dengan melakukan analisis probit.Hasil: Hasil penelitian menunjukkan tidak terdapat perbedaan secara statistik persent ase kematian M. domestica setelah dikontakkan dengan formulasi Cymbopogon citratus dengan berbagai konsentrasi. Nilai LC50 formulasi Cymbopogon citratus setelah dikontakkan selama 24 jam terhadap M. domestica adalah 26,51%.Simpulan: Cymbopogon citratus mempunyai potensi membunuh lalat Musca domestica setelah dikontakkan selama 24 jam. ABSTRACTTitle: LC50 value of Cymbopogon citratus for Musca domesticaBackground: Insect control is generally carried out using chemicals that can threaten human health and the environment. The use of plants as bioinsecticides needs to be developed. Cymbopogon citratus is known to contain substances that have the potential to be insecticides. This study aims to determine the LC50 value of Cymbopogon citratus formulations for M. domestica.Method: This research was quasi-experimental. The formulation was carried out by extracting Cymbopogon citratus using methanol and evaporating it. Cymbopogon citratus extract was diluted using aqua dest with concentrations of 20%, 25%, 30%, and 35%. The house flies (M. domestic) used were adult flies that were caught into the flytrap by being given the bait and put into a test cage measuring 30x30x30 cm3. The difference in the percentage of deaths was analyzed using one-way ANOVA, and the LC50 value was determined to conduct probit analysis.Result: The results showed no statistical difference in the percentage of M. domestica deaths after contacting with Cymbopogon citratus formulations with various concentrations. The LC50 value of Cymbopogon citratus formulation after being contacted with 24 -hour greetings to M. domestica was 26.51%.Conclusion: Cymbopogon citratus has the potential to kill Musca domestica after being contacted for 24 hours.
Halaman Sampul
Authors: Editor Editor
Published: March 2021

Cover, Dewan Redaksi, Daftar Isi
Translanguaging practices of Chinese/English bilingual engineers’ communications in the workplace
Authors: Du Juan , Zhou Xiaodi
Published: March 2021

Existing literature argues for the urgent need to improve workplace and professional communication in the engineering field across the world. This paper reports on a study examining Chinese/English bilingual engineers’ translanguaging practices in their communications in English-speaking high-tech corporations in the United States. Evidence showed that bilingual engineers translanguaged extensively to construct meaning to meet the diverse communication needs at their workplace, which enables them to demonstrate their professional talents and skills. However, when English was the sole language for the interaction, they struggled to sound like English native speakers to convey their ideas and present their work, which disadvantaged them professionally, socially and emotional as professionals. Therefore, this study calls for a creation of a translanguaging space in the workplace to empower bilingual engineers and also a need to modify engineering education programs that recognize multilingual competence of bilinguals and enhance the development of their English professional communication ability (speaking and writing) in higher education.
Ethiopia’s Bilateral Investment Treaties and Environmental Protection; The Need of Re-Negotiation for Corporate Responsibility
Authors: Abate Ayalew
Published: March 2021

This article argues that the bulk of the bilateral investment treaties (BITs) that Ethiopia has ever concluded, to regulate its bilateral foreign investment relations, don’t contain an environmental provision that require investing corporations to discharge responsibility towards environment and there is a pressing call for either to re-negotiate, update or engage in concluding of environmental side agreements (ESA). To substantiate the argument the trends of BIT making is assessed, the status of Ethiopian BITs have been evaluated through content analysis, environmental responsibility of Ethiopia has been examined both from domestic and international perspective, relevant reasons for the regulation of environment in foreign investment through BIT have been discussed and justifications for the need to renegotiate, update or make ESA in Ethiopia have been highlighted.
Ultrasonic cavitation driven fabrication of organic solvent free lignin/prochloraz nano capsules to promote resistance to photolysis and rain wash, and provide extended release performance
Authors: Chen Jingtian , Wang Miao , Qian Yong , Tan Shanyuan , Wang Huan , Zhou Mingsong , Que Xueqing
Published: March 2021

Lignin is a natural macromolecular sun blocker and provides an ideal protection material for pesticides that have poor photostability. In this study, alkali lignin/prochloraz capsules (AL-P) were prepared via one-pot ultrasonic cavitation. The results demonstrated that the produced AL-P were uniform spheres with sizes of 170–375 nm. The prochloraz encapsulation efficiency (EE) and loading capacity (LC) reached as high as 91.8 and 98.5%, respectively. Adding a small of surfactant reduced the size of the capsules, but both EE and LC were decreased. AL-P exhibited excellent extended release performance. The cumulative release of AL-P in the first 45 h was 76.1% and continuous release was maintained after 96 h. The resulting AL-P have improved photostability under UV irradiation radiation. Finally, AL-P capsules were sprayed on the mango leaves and bananas to act as preservatives, AL-P capsules had stronger rain wash resistance and were better preserved demonstrating their industrial applicability. Together, organic solvent free AL-P capsules demonstrate a method to improve the efficiency of photosensitive pesticides.
Private Agricultural R&D: Do the Poor Benefit?
Authors: Anderson Jock R. , Birner Regina , Nagarajan Latha , Naseem Anwar , Pray Carl E.
Published: March 2021

Private agricultural research and development can foster the growth of agricultural productivity in the diverse farming systems of the developing world comparable to the public sector. We examine the extent to which technologies developed by private entities reach smallholder and resource-poor farmers, and the impact they have on poverty reduction. We critically review cases of successfully deployed improved agricultural technologies delivered by the private sector in both large and small developing countries for instructive lessons for policy makers around the world.
An analysis of research quality underlying IDSA clinical practice guidelines: a cross-sectional study
Authors: Greiner Benjamin , Essex Ryan , Wheeler Denna
Published: March 2021

Context

As a result of new developments in medicine, the need for evidence-based clinical practice guidelines (CPG) is of utmost importance. However, studies have shown that many medical societies are using low quality research to develop CPGs.

Objectives

To evaluate the quality of research underlying the CPGs issued by the Infectious Diseases Society of America (IDSA).

Methods

We examined 29 CPGs issued between January 1, 2012 and December 31, 2019 and classified each by research quality according to levels reported by the CPG authors and previously specified by the IDSA: Levels I through III, corresponding to high, moderate, and low quality of evidence, respectively. Each ranking was cross-checked with a second researcher to improve inter-rater reliability. To analyze evolution of research quality over time, three updated CPGs were randomly selected and compared to their original versions. Chi-square analysis was then performed to determine statistical significance.

Results

We evaluated the quality of research for 2,920 recommendations within the 29 CPGs that met our criteria and found that 418 (14%) were developed using high-quality (Level I) research from randomized, controlled trials. Of the remaining recommendations, 928 (32%) were based on moderate quality research (observational studies) and 1574 (54%) on low quality research (expert opinion). A Pearson chi-squared analysis indicated no-statistically significant difference between original guidelines or their subsequent updates for Clostridium difficile (χ2=0.323; n=85; degrees of freedom [df]=2; p=0.851), candidiasis (χ2=4.133; n=195; df=2; p=0.127), or coccidiomycosis (χ2=0.531; n=95; df=1; p=0.466).

Conclusions

The proportion of high-quality research underlying guideline recommendations is remarkably low, indicating that moderate and low quality evidence is still influencing infectious disease guidelines despite IDSA standards. Moreover, the quality of research has not significantly changed over time. IDSA CPGs are a formidable source of information for clinicians, but an increased number of quality studies should be utilized to further guide CPG development.
Evaluating transition in Turner syndrome in the West of Scotland
Authors: Zahra Baryab , Lyall Helen , Sastry Aparna , Freel E. Marie , Dominiczak Anna F. , Mason Avril
Published: March 2021

Background

A Turner Syndrome (TS) Transition clinic, Royal Hospital for Children Glasgow (RHCG), with paediatric and adult endocrinology/gynaecology teams was established in 1998 with an aim of improving health outcomes in TS throughout the lifespan.

Objective

To evaluate the success of our TS transition service, focussing on evaluating established follow-up after transfer to adult services.

Methods

Girls attending the TS Transition clinic at Royal Hospital for Children Glasgow, 1998–2017, were identified. Attendance data were obtained from patient records and an electronic appointment system. We assessed good and late early attendance in our cohort of TS patients as well as established endocrine follow-up, defined as those still attending adult endocrine services 3 years after transfer. Success of TS transition was determined by the proportion of girls in established endocrine follow-up.

Results

Forty-six girls (median age 18.3 yrs) were identified. Thirty-six, 36/46 girls transferred prior to 2015 and 26 of those (72%) were in established follow-up at 3 years, 22/36 girls had met with an Adult specialist prior to transfer and 14/36 had not met with an adult specialist prior to transfer. Twenty-one (80.7%) were good early attenders (p = 0.10). In the early attenders’ cohort, there was no significant difference between those that had and had not met an adult specialist prior to transfer.

Conclusion

A significant proportion of girls with TS are currently lost to endocrine follow-up following transfer to adult clinics. Early attendance at an adult clinic appears to predict established long-term follow-up. Strategies to improve early attendance and long-term endocrine follow-up are needed to ensure lifelong health needs are addressed.
Dual diagnosis of Ochoa syndrome and Niemann-Pick disease type B in a consanguineous family
Authors: Cesur Baltacı Hande Nur , Taşdelen Elifcan , Topçu Vehap , Eminoğlu Fatma Tuba , Karabulut Halil Gürhan
Published: March 2021

Objectives

Ochoa syndrome (UFS1; Urofacial syndrome-1) is a very rare autosomal recessive disorder caused by mutations in the HPSE2 gene that results bladder voiding dysfunction and somatic motor neuropathy affecting the VIIth cranial nerve. Niemann-Pick disease is a rare autosomal recessive lysosomal storage disorder with systemic involvement resulting from sphingomyelinase deficiency and generally occurs via mutation in the sphingomyelin phosphodiesterase-1 gene (SMPD1).

Case presentation

Here, we report a 6-year-old girl with symptoms such as urinary incontinence, recurrent urinary tract infections, peculiar facial expression, mainly when smiling, hypertelorism, constipation, incomplete closure of eyelids during sleep and splenomegaly. Homozygote mutations in two different genes responsible for two distinct syndromes were detected in the patient. Homozygous NM_000543.5:c.502G>A (p.Gly168Arg) mutation was found in the SMPD1 gene causing Niemann-Pick disease. In addition, some of the clinical features were due to a novel homozygous mutation identified in the HPSE2 gene, NM_021828.5:c.755delA (p.Lys252SerfsTer23).

Conclusions

Here, we discuss about the importance of considering dual diagnosis in societies where consanguineous marriages are common. Accurate diagnosis of the patient is very important for the management of the diseases and prevention of complications.
Re-thinking Information Ethics: Truth, Conspiracy Theories, and Librarians in the COVID-19 Era
Authors: Lor Peter , Wiles Bradley , Britz Johannes
Published: March 2021

The COVID-19 pandemic is an international public health crisis without precedent in the last century. The novelty and rapid spread of the virus have added a new urgency to the availability and distribution of reliable information to help curb its fatal potential. As seasoned and trusted purveyors of reliable public information, librarians have attempted to respond to the “infodemic” of fake news, disinformation, and propaganda with a variety of strategies, but the COVID-19 pandemic presents a unique challenge because of the deadly stakes involved. The seriousness of the current situation requires that librarians and associated professionals re-evaluate the ethical basis of their approach to information provision to counter the growing prominence of conspiracy theories in the public sphere and official decision making. This paper analyzes the conspiracy mindset and specific COVID-19 conspiracy theories in discussing how libraries might address the problems of truth and untruth in ethically sound ways. As a contribution to the re-evaluation we propose, the paper presents an ethical framework based on alethic rights—or rights to truth—as conceived by Italian philosopher Franca D’Agostini and how these might inform professional approaches that support personal safety, open knowledge, and social justice.
circAPLP2 promotes colorectal cancer progression by upregulating HELLS by targeting miR-335-5p
Authors: Xiang Rui , Feng Min , Zhou Xin , Ma Lihong , Dong Ningfei
Published: March 2021

Background

Colorectal cancer (CRC) is one of the deadliest cancers in the world. Increasing evidence suggests that circular RNAs (circRNAs) are implicated in CRC pathogenesis. This study aimed to determine the role of circAPLP2 and explore a potential mechanism of circAPLP2 action in CRC.

Methods

The expression of circAPLP2, miR-335-5p and helicase lymphoid-specific (HELLS) mRNA in CRC tissues and cells was measured by quantitative real-time polymerase chain reaction (qPCR). The functional effects of circAPLP2 on cell cycle progression/cell apoptosis, colony formation, cell migration, invasion and glycolysis metabolism were investigated by flow cytometry assay, colony formation assay, wound healing assay, transwell assay and glycolysis stress test. Glycolysis metabolism was also assessed by the levels of glucose uptake and lactate production. The protein levels of HELLS and HK2 were detected by western blot. The interaction between circAPLP2 and miR-335-5p, or miR-335-5p and HELLS was verified by dual-luciferase reporter assay. The role of circAPLP2 on solid tumor growth in nude mice was investigated.

Results

circAPLP2 and HELLS were overexpressed, but miR-335-5p was downregulated in CRC tissues and cells. Functional analyses showed that circAPLP2 knockdown suppressed CRC cell cycle progression, colony formation, migration, invasion and glycolysis metabolism, induced cell apoptosis and blocked solid tumor growth in nude mice. Moreover, miR-335-5p was a target of circAPLP2, and miR-335-5p could also bind to HELLS. Rescue experiments presented that miR-335-5p inhibition reversed the effects of circAPLP2 knockdown, and HELLS overexpression abolished the role of miR-335-5p restoration. Importantly, circAPLP2 could positively regulate HELLS expression by mediating miR-335-5p.

Conclusion

circAPLP2 triggered CRC malignant development by increasing HELLS expression via targeting miR-335-5p, which might be a novel strategy to understand and treat CRC.
Re-Assessing the Evidentiary Threshold for Zinā’ in Islamic Criminal Law: A De Facto Exemption Proposal
Authors: Ahmad Hassan M.
Published: March 2021

This article considers the four eyewitness threshold for zinā’ in Islamic criminal law. In some Muslim-majority countries where zinā’ remains an offence, judiciaries have by-passed the threshold by accepting singular confessions from male fornicators or, otherwise, inferring fornication from pregnancy outside of marriage. As a result, a disproportionate number of women have been prosecuted, convicted, and even punished for zinā’. I assert that the four-eyewitness threshold allows for an alternative way to view zinā’ that can result in a different set of consequences. If the threshold is taken seriously such that it becomes the only evidentiary basis upon which a zinā’ conviction can be entered, it will create an effective or de facto exemption where alleged perpetrators can never be convicted, except in the rarest cases where four independent eyewitnesses can be corralled. If adopted, this approach would provide a principled basis to reject opportunistic confessions that deflect punishment to accused female fornicators. And as an ‘internal’ solution that arises within the framework of the sharī’a, a de facto exemption approach is more likely to be perceived as legitimate when compared with proposed solutions that find their basis in international human rights legal instruments.
Noise complaints during a pandemic: A longitudinal analysis
Authors: Yildirim Yalcin , Arefi Mahyar
Published: March 2021

COVID-19 has affected people’s lives in different ways from reduced mobility and staying-at-home orders to other daily life routines. These changes have, in turn, affected the quality of life in urban environments including air quality and noise. The noise aspect, for example, suggests quieter environments due to fewer vehicles on streets, and less human activities. On the other hand, staying at home may cause more activities happening at the building level, i.e., more people in buildings may make more noise for neighbors. In order to understand this nexus, the study examines the noise complaints data in Dallas, USA. To do this, the study first compares the noise complaints after the COVID-19 intercourse and the same data period in 2019. Findings surprisingly show reduced noise complaints during the COVID-19 time frame by about 14% compared to the pre-COVID-19 period. The majority of this reduction occurred in and around the city center. In other words, the noise complaints seem more spatially dispersed at the outskirts of the city. Another finding that directs more detailed analyses, however, considers the massive reduction of ridership, traffic circulation, and building permits. This needs some other techniques for determining the sources for incommensurate noise complaints.
Katarzyna Luter z domu von Bora (1499-1552) – kobieta, która dokonała wyboru. Losy żony Reformatora
Authors:   Uniwersytet w Białymstoku, Gąsowska Magdalena
Published: March 2021

Kiedy 31 października 1517 r. augustiański mnich niezadowolony z poczynań papieża wygłosił, bądź przybił do drzwi kościoła zamkowego w Wittenberdze swoje 95 tez, nikt, włącznie z samym Marcinem Lutrem nie przypuszczał, że czyn ten będzie miał tak dalekosiężny wydźwięk dla całej Europy, a jego poglądy będą do dzisiaj rozpatrywane pod względem teologicznym, moralnym, społecznym czy ekumenicznym. Od tamtego wydarzenia, które wywróciło ówczesny świat, w tym roku mijają 503 lata w trakcie których na temat samego Reformatora powstało setki tysięcy stron opracowań. Niemieccy naukowcy uważają wręcz, że żadna inna postać z niemieckiej historii nie doczekała się tylu opracowań biograficznych, co Marcin Luter. Natomiast inaczej wygląda sytuacja, kiedy zastanowimy się nad postacią żony Lutra – Katarzyny von Bora. W licznych opracowaniach dotyczących reformacji, postać Katarzyny zawsze się pojawia, jednak zwykle są to zdawkowe informacje zawierające głównie trzy daty: jej narodzin, śmierci oraz ślubu z Marcinem Lutrem. Katarzyna zajmowała się nie tylko wychowywaniem dzieci. Prowadziła też dom Lutra. Miał on bowiem 40 pokoi, w których mieszkali goście i studenci Lutra z całych Niemiec. Klasztor zamieniony na „dom otwarty” wymagał dużych nakładów finansowych. Do tego dochodziły wydatki związane z utrzymaniem całej dużej rodziny. Aby je pokryć, Katarzyna musiała zasilić domowy budżet zbiorami z pola, pracą w ogrodzie, hodowlą świń, przyjmowaniem czynszu i browarnictwem. Musiała więc być – jak pisała Aniela Szarek w artykule Najsławniejsza pastorowa świata – „pielęgniarką, nauczycielką, wychowawczynią, kucharką, ogrodniczką, lekarką, budowniczym i handlowcem”. Katarzyna Luter z domu von Bora była jedną z kobiet, które potrafiły w patriarchalnym społeczeństwie same decydować o swoim losie. To ona postanowiła opuścić narzucony jej stan zakonny, ponadto wybrała sobie męża. To ona kreowała swoją pracę: domową, wychowawczą, gospodarczą a nawet kościelną. Potrafiła skłonić męża do zaakceptowania jej spojrzenia na świat, do porzucenia niektórych uprzedzeń. Moim zdaniem jest ona prawdziwą feministką i emancypantką, tak jak wiele innych kobiet od tysięcy lat.
Kwestia kobieca, transnarodowość i social network. Międzynarodowe zjazdy działaczek organizacji kobiecych do 1914 roku
Authors:   Uniwersytet Szczeciński, Szudarek Agnieszka
Published: March 2021

Celem artykułu jest ukazanie międzynarodowych kongresów działaczek organizacji kobiecych jako narzędzi w komunikacji międzynarodowej, a także jako wydarzeń kluczowych dla poszerzania transnarodowej sieci kontaktów między aktywistkami i budowania kanałów transferu treści programowych ruchu kobiecego do narodowych przestrzeni dyskursu na temat kwestii kobiecej. Kongresy były wyrazem dojrzałości środowiska aktywistek. Nadanie im charakteru międzynarodowego w 1878 r. miało służyć ukazaniu kwestii kobiecej jako istotnego problemu wymagającego rozwiązania. Początkowo taki charakter miały tylko z nazwy. Dopiero te, które współorganizowała założona w 1888 r. Międzynarodowa Rada Kobiet w rzeczywistości zbierały działaczki z szeregu państw należących co zachodnioeuropejskiego kręgu cywilizacyjnego. Sprzyjała temu nie tylko organizacja Rady oparta na kryterium narodowym (państwowym), ale także jej umiarkowany program. Transferowany poprzez prasę, osobiste kontakty, publikacje, korespondencję czy wykłady uczestniczek zjazdów mobilizował lokalne działaczki, wskazywał kierunki i formy aktywności.
O prominskim imenima u romanu Život nastanjem sjenama Ivana Aralice
Authors: Vidović Domagoj
Published: March 2021

U ovome se radu obrađuju različita imena (poglavito antroponimi) u romanu Život nastanjen sjenama Ivana Aralice koja se odnose na piščev zavičaj, Prominu, te se uspoređuju s tumačenjem tih imena u relevantnim onomastičkim radovima u kojima se govori o toj problematici. Ujedno se upućuje na određene nazivoslovne prijepore poput odnosa etimološkoga i temeljnoga imena te službenoga i neslužbenoga imena.
Roman Danuncijada – prethodnik postmodernističkoga povijesnoga romana (osvrt o sto pedesetoj godišnjici rođenja Viktora Cara Emina)
Authors: Franković Sanja
Published: March 2021

Tekst je napisan prigodom sto pedesete godišnjice rođenja Viktora Cara Emina (1870. – 1963.) i osvrće se na autorovo najzrelije djelo, roman Danuncijadu (1946.). Budući da je u Carevu romanu Šenoina teleološka koncepcija povijesnoga romana zamijenjena neteleološkom, pripovjedač uvodi ironiju, kojom se povijest negira kao logičan slijed. Karnevalizacijom, grotesknim likom povijesne osobe kao antijunaka i citatnim dijalogom s tradicijom Car se u Danuncijadi približio dosta kasnijoj postmodernoj poetici povijesnoga romana, stoga neke njegove literarne postupke prepoznajemo u povijesnim romanima autora kao što su Fabrio, Kušan i Brešan.
Kako je "pranje ruku" ispralo kolektivno i individualno pamćenje– pilatovski motiv u stvaralaštvu Ivana Aralice
Authors: Odža Ivana
Published: March 2021

U nekoliko Araličinih književnih djela (pripovijetki i romana) razmatra se uporaba pilatovskoga motiva. Taj se motiv promatra i unutar usmenoknjiževne tradicije kao supstrata koji je u velikoj mjeri zastupljen u ukupnome Araličinu stvaralaštvu. Dok se u usmenoknjiževnim oblicima Poncije Pilat uvelike ne udaljava od biblijske slike, potvrđujući tako kolektiv kao intertekstualni prijenosnik nepodložan znatnim idejnim intervencijama u odnosu na izvorni tekst, različitim intertekstualnim tehnikama Aralica izgrađuje vlastiti odnos prema pilatovskome motivu. Uz najčešći pristup u umjetničkoj književnosti koji Poncija Pilata oblikuje kao zaseban književni lik, individualizirajući ga i često mijenjajući njegovu biblijsku poziciju, Aralica se koristi drugačijim postupkom tvorbe lika, što posljedično utječe i na njegovu intertekstualnu funkciju. Temeljnu biblijsku poziciju prototipskoga karaktera Aralica nadograđuje nizom značenja. Mrežom postavljenih značenja traži odgovor na pitanje odnosa osobne i kolektivne odgovornosti. Naslonjen djelomič- no na koncepciju povijesti definiranu vlastitim povijesnim romanima (iako sva analizirana djela nisu pisana u tome ključu), prije svega na povijest kao (ne)plodno pamćenje, opredjeljuje se, iako ne uvijek jasno, za osobnu odgovornost kao (mogući) ispravan put za oblikovanje kolektivne odgovornosti.
Praznovjerje kao okosnica romana Japunže Ivana Aralice
Authors: Sunara Nikola
Published: March 2021

U radu se analiziraju primjeri praznovjerja pronađeni u romanu Japundže Ivana Aralice. Riječ je o vjerovanjima koja izlaze izvan okvira kanoniziranih vjerskih učenja i u sebi često sadrže elemente poganskih vjerovanja. Analizom su pronađeni primjeri vjerovanja u moć zapisa, sretnih i nesretnih dana, Mjeseca i životinja čije se ponašanje tumačilo kao predznak nadolazećih događaja. U njima su amalgamirana pretkršćanska i kršćanska vjerovanja, a u slučaju zapisa i tekstovi islamske provenijencije. Uz vjerovanja se vežu predmeti, poput moći od pomoći, i obredni oblici ponašanja, kao što je način korištenja spomenutih moći, pozdrav mladom Mjesecu ili proricanje budućnosti iz ponašanja životinja. Spomenuti fenomeni čine okosnicu fabule romana, a kao jedan od najvažnijih identitetskih elemenata presudni su za oblikovanje lika Stane Antolović.
Europski gradovi u poeziji Dragutina Tadijanovića
Authors: Lazibat Tonći
Published: March 2021

U svom je dugogodišnjem stvaralačkom radu Dragutin Tadijanović (1905. – 2007.) tematizirao i uvrštavao širok spektar pjesničkih motiva. Kao pjesnik koji je pomno bilježio mjesto i vrijeme nastanka svojih pjesama, čineći ih gotovo ravnopravnim u odnosu na tekst, omogućio je, kasnijim povjesničarima i teoretičarima književnosti, analizirati pjesme kao specifičan autobiografski diskurs. Pritom uvid u Tadijanovićevu biografiju daje naslutiti da je grad u njegovu životu, a samim time i u stvaralaštvu, imao veliku važnost. U tom je smislu cilj ovoga rada bio prepoznati, analizirati i raspraviti u kojoj se funkciji pojavljuju europski gradovi u njegovim pjesmama. Iako bismo gotovo svu Tadijanovićevu poeziju mogli pročitati iz Sabranih pjesmama (2005.) i Zelenog voća (2006.), za potrebe smo ovoga istraživačkog rada konzultirali samo prvu zbirku. Naime, u Zelenom voću nema ni jedne pjesme koja udovoljava navedenoj temi rada. Da bismo došli do navedenoga cilja, učinili smo sljedeće: (1) utvrdili zastupljenost pjesama u kojima je europski grad mjesto nastanka pjesme i / ili tema, odnosno motiv, (2) izdvojili konkretne europske gradove iz Tadijanovićeve poezije, (3) prikazali odnos gradova i država kojima pripadaju, s obzirom na zastupljenost u pjesmama te (4) analizirali pjesnikov doživljaj pojedinoga grada, s obzirom na njegovu dob te teme i motive pjesama.
Ženski oblici koji potječu od imenica muškog roda u hrvatskim frazemima
Authors: Markežić Tjaša
Published: March 2021

Ovaj se članak bavi ženskim oblicima koji potječu od imenica muškog roda (takozvani feminativi) u hrvatskim frazemima, prikupljenim u različitim frazeološkim rječnicima. Ispitivanje korpusa Hrvatske jezične riznice ukazuje da je upotreba takvih frazema u cjelini ili njihovih dijelova u svakodnevnom jeziku prilično raširena, a primjeri su odabrani da naznače moguću raznolikost elemenata. Nekoliko primjera upotrebe frazema prikupljeno je i putem hrvatske tražilice Google.com. Također smo primijetili da je žena kao društveno biće još uvijek zanemarena. Neki primjeri izražavaju izrazito negativnu konotaciju.
O stilu književnih prevoditelja kroz prizmu ponovnog prevođenja na primjeru hrvatskih prijevoda Pirandellova romana Njezin muž
Authors: Milanko Sandra
Published: March 2021

U članku se analiziraju prvi i ponovljeni prijevod Pirandellova romana Njezin muž koje potpisuju Dubravko Dujšin i Karmen Milačić s ciljem definiranja njihova prevoditeljskog stila. Traduktološka opažanja popraćena su statistič- kim podatcima dobivenima izradom paralelnoga korpusa koji se sastoji od Pirandellova izvornika i dvaju prijevoda. Izdvojeni su stilistički markeri broj i prosječna dužina rečenice, omjer različnica i pojavnica, upotreba aorista u pripovijedanju i glagolskih vremena u slobodnome neupravnom govoru, frazemi i upotreba dijalektizama. Osim korpusne metodologije u članku se primjenjuje i arheologija prijevoda kojom se detaljno opisuju kontekstualni glasovi izvornika i prijevoda. Rezultati analize osporavaju hipotezu ponovljenoga prijevoda, a prevoditeljski stil dvaju prevoditelja uvelike je određen iskustvom i naobrazbom u prevođenju.
Cadenas productivas en la economía-mundo antes de 1800
Authors: Hopkins Terence K. , Wallerstein Immanuel , Tamayo Belda Eduardo
Published: March 2021

Cadenas productivas en la economía-mundo antes de 1800.
Extractivismo marino-colonial. Apropiación asimétrica de recursos marinos en el golfo de California (México) siglos XVI-XXI
Authors: Ortega Santos Antonio
Published: March 2021

En la península y en el golfo de California, el proceso de conquista colonial impuso un proceso de antropización-colonización de la relación sociedad-naturaleza a lo largo del tiempo moderno y contemporáneo. Desde el siglo XVI, este cambio se implementó mediante la inserción de los recursos naturales terrestres y marinos disponibles en el territorio sudcaliforniano en el marco de la Economía Mundo. La península y el golfo de California se vieron sometidos a un proceso, a largo plazo, de saqueo y despojo territorial que denomino “Apropiación Asimétrica” (que se traduce en una línea temporal de cuatro momentos históricos, algunos coetáneos, desde el siglo XVI al siglo XXI). En el primer momento de esta línea temporal, se describe en el texto cómo la Corona transfirió, mediante diversos sistemas de cesión territorial, el control de recursos (perlas, acuacultura, guano, sal, etc.) hacia empresarios privados encargados de extraer el capital natural para comercializarlo en mercados globales entre el siglo XVI y el siglo XX. Esta capitalización/privatización de recursos costeros-marinos a lo largo del siglo XX se evidenció en un proceso de especulación financiero territorial, orientado al desarrollo del turismo de masas como eje del modelo de desarrollo económico (tercer y cuarto momento histórico de la Apropiación Asimétrica que se analiza en el texto. La propuesta de metodología de investigación parte del trabajo que desarrollamos en el campo de la Historia Ambiental, entendida como estudio sobre las relaciones entre sociedad y naturaleza a lo largo del mundo moderno y contemporáneo, estudiado mediante el análisis de los documentos archivísticos y bibliografía de coetáneos, viajeros o documentos institucionales. Esta propuesta metodológica supone el estudio de los cambios territoriales, ambientales y socioeconómicos junto al impacto de los mismos en el capital natural del territorio sudcaliforniano, procesos que generan conflictos y luchas contra el extractivismo y despojo como modelo económico. Desde el campo de la Historia Ambiental, el concepto de extractivismo es definido como transferencia de bienes naturales de manejo comunitario hacia la esfera del mercado, enajenados los pueblos y beneficiados sectores empresariales con este proceso de privatización. De igual manera, el concepto de apropiación asimétrica implica la identificación de cómo la transferencia verificada mediante el extractivismo y despojo territorial impacta sobre la arquitectura del modelo de desarrollo económico generando episodios y realidades de injusticia ambiental, dando lugar a importantes desequilibrios territoriales. Estos desequilibrios territoriales tienen una matriz histórica que la Historia Ambiental permite narrar como un contínuum, pero que como práctica de colonización del territorio llega hasta inicios del siglo XXI como demuestra el estudio del impacto del capitalismo financiero en Baja California.
Resilient H-infinity filtering for networked nonlinear Markovian jump systems with randomly occurring distributed delay and sensor saturation
Authors: Nithya Venkatesan , Sakthivel Rathinasamy , Ren Yong
Published: March 2021

The H∞ filtering problem for a class of networked nonlinear Markovian jump systems subject to randomly occurring distributed delays, nonlinearities, quantization effects, missing measurements and sensor saturation is investigated in this paper. The measurement missing phenomenon is characterized via a random variable obeying the Bernoulli stochastic distribution. Moreover, due to bandwidth limitations, the measurement output is quantized using a logarithmic quantizer and then transmitted to the filter. Further, the output measurements are affected by sensor saturation since the communication links between the system and the filter are unreliable and is described by sector nonlinearities. The objective of this work is to design a quantized resilient filter that guarantees not only the stochastic stability of the augmented filtering error system but also a prespecified level of H∞ performance. Sufficient conditions for the existence of desired filter are established with the aid of proper Lyapunov–Krasovskii functional and linear matrix inequality approach together with stochastic analysis theory. Finally, a numerical example is presented to validate the developed theoretical results.
THE PROBLEM OF NARRATION IN NOTES FROM A DEAD HOUSE BY FYODOR DOSTOEVSKY
Authors: Batalova Tamara
Published: March 2021

Within the framework of Pavel Medvedev’s sociological poetics, the article identifies and studies the features of the narrative in Fyodor Dostoevsky’s Notes from a Dead House, and examines the role of these features in expressing the key idea of this novel, namely the desire of convicts for freedom, for “resurrection from the dead”. From this point of view, the author examines the significance of the narrator’s duality (Goryanchikov and Goryanchikov-Dostoevsky) and the juxtaposition of the characters in the narrative (positive and negative). He also analyzes the compositional function of the XI chapter of the first part of Notes from a Dead House, “Presentation”, in the plot. The Christian faith plays the vital role in the expression of the essential idea of the work. An open-minded attitude to people, a friendly, Christian approach towards them is a distinctive feature of Goryanchikov-Dostoevsky and all the positive characters in the book. Inspired by the celebration of the Nativity of Christ, the convicts staged a theatrical performance, which alters the moral state of both the actors and the audience, fortifies their sense of self-esteem required to resist the prison orders that “deaden” people, and strengthens the prisoners’ desire for freedom, for “resurrection from the dead”. The article concludes that Notes from a Dead House is the beginning of aesthetic and artistic changes that manifested themselves in Dostoevsky’s post-prison works.