bluuebunny/crossref_metadata_2025 huggingface dataset:
Toward a holistic understanding of sustainability in corporations: resource-based view of sustainable supply chain management
Authors: Arda Ozlem Ayaz , Montabon Frank , Tatoglu Ekrem , Golgeci Ismail , Zaim Selim
Published: December 2021

Purpose

While the three interconnected aspects of the triple bottom line -environmental, social and economic sustainability- are well-established, these aspects have insufficiently been addressed together in the supply chain management literature. Thus, the purpose of this paper is to examine whether environmental and social performance mediates the relationship between environmental management practices and operational performance and whether operational performance mediates the relationship between environmental and social performance and financial performance.

Design/methodology/approach

Drawing on a data set of 208 firms operating in a wide range of manufacturing industries, the authors test the hypotheses using structural equation modeling. The research context for the study is Turkey, an important emerging market and one of the nexuses of European and Asian supply chains.

Findings

The findings indicate that all three aspects of sustainability have mutually supportive relationships as demonstrated by positive mediating mechanisms between environmental management practices and operational performance and between environmental and social performance and financial performance. The mediation results correspond with the resource-based view. They indicate that building up capabilities and resources in the form of environmental management practices supports three areas of the triple bottom line and boosts firms’ financial performance.

Originality/value

Research on sustainability is well-established, yet supply chain management research has, thus, far paid insufficient attention to all three aspects. This paper, thus, sets itself apart by explicitly considering all three aspects of sustainability and contributes to understanding how they relate to one another.
Secondary school teachers’ perceptions of adolescent social anxiety and learning and development in the classroom
Authors: Higham Melissa , Demkowicz Ola
Published: December 2021

Social anxiety has been linked with adverse consequences for adolescents in education, including low self‐efficacy, poor academic attainment and difficulties with social functioning. However, studies have not considered the phenomenon from an educator’s point of view. We set out to explore the perceptions of secondary school teachers concerning socially anxious adolescents and the implications of social anxiety for their learning and development. Seven secondary school teachers in the north west of England took part in semi‐structured interviews focused on their lived experiences of supporting socially anxious adolescents. The findings suggest that educators perceive social anxiety to have the potential to be persistent and debilitating, impeding learning and development. The findings also demonstrate that teachers are aware of social anxiety and supportive strategies, but face difficulties in disentangling different anxious behaviours and providing differentiation. Conclusions indicate that recurring professional development and teacher training surrounding anxieties and comorbid behaviour may alleviate negative consequences for learning and development.
Utilising power analyses and occupancy modelling to inform population monitoring of the regionally endangered black‐striped wallaby (Macropus dorsalis) in New South Wales
Authors: McHugh Darren , Goldingay Ross L.
Published: December 2021

Small macropodoid marsupials are well represented among Australia’s extinct and threatened mammals. Population monitoring is central to understanding how remaining species respond to on‐going landscape change and threatening processes on private land and within managed conservation reserves. Camera trapping and occupancy modelling provide a reliable approach to monitor these often cryptic species. However, understanding the survey effort required to detect population declines of a given magnitude with high statistical certainty is often overlooked. We use empirical data from camera trapping and occupancy modelling to determine an optimal survey design for a regionally endangered population of the black‐striped wallaby. We established a 1200 ha grid of 60 cameras and sampled in three 30‐day intervals over a 1‐year period. We investigated factors that may influence occupancy and detection followed by power analyses with our broad objective being to devise a monitoring program that would be robust enough to detect a 50% decline with at least 80% power. This species was not detected at rainforest sites. Naïve occupancy within eucalypt forest was 0.42. The detection probability (using 5‐day detection occasions) varied with season (from 0.17 ± 0.04 in autumn to 0.34 ± 0.05 in spring). Occupancy was negatively influenced by shrub cover and negatively influenced by elevation. We found no apparent influence of dingo detection on occupancy or detection of the black‐striped wallaby. We explored different configurations of detection sites and number of survey occasions to satisfy our 50:80 criteria when initial occupancy was 0.40. Sampling 60 sites for a minimum of 30 days would satisfy these criteria. Power analyses can inform optimal designs for threatened species monitoring and similar investigations should be conducted for other threatened small macropods to assist their conservation.
Sex‐specific developmental trajectories of eczema from infancy to age 26 years: A birth cohort study
Authors: Ziyab Ali H. , Mukherjee Nandini , Zhang Hongmei , Arshad Syed Hasan , Karmaus Wilfried
Published: December 2021

Background

Eczema is a common inflammatory skin disease with varying developmental trajectories/patterns that are influenced by different risk factors. The aim of this study was to investigate eczema development from infancy to early adulthood by identifying distinct developmental trajectories that describe disease patterns over time and evaluate the role of prenatal and early‐life risk factors.

Methods

The Isle of Wight Birth Cohort (n = 1456) was prospectively assessed at birth, 1, 2, 4, 10, 18 and 26 years. In all assessments, eczema was defined as chronic or chronically relapsing itchy dermatitis lasting >6 weeks with characteristic morphology and distribution in the past 12 months. Developmental trajectories of eczema between 1 or 2 and 26 years were identified separately for males and females by applying semiparametric mixture models. Associations were assessed by applying a modified Poisson regression to estimate adjusted risk ratios (aRR) and 95% confidence intervals (CI).

Results

In both males and females, the following eczema developmental trajectories were identified: unaffected/transient (males: 77.7% vs. females: 73.0%), mid‐onset late‐resolving (males: 7.8% vs. females: 4.4%), late‐onset (males: 5.2% vs. females: 9.5%) and early‐onset persistent (males: 9.3% vs. females: 5.4%). In females, an additional trajectory was identified as follows: early‐onset early‐resolving (7.7%). Among males, filaggrin gene (FLG) variants (aRR = 2.45, 95% CI: 1.34–4.46) and paternal eczema (2.66, 1.39–5.08) were associated with the early‐onset persistent trajectory. Among females, maternal eczema (2.84, 1.42–5.70) and high birthweight (2.25, 1.08–4.69) were associated with the early‐onset persistent trajectory.

Conclusions

Four and five trajectories represented eczema development among males and females, respectively, with different predisposing risk factors. Our results indicate that males and females may experience a different course of eczema.
Phonetic versus spatial processes during motor‐oriented imitations of visuo‐labial and visuo‐lingual speech: A functional near‐infrared spectroscopy study
Authors: Zhao Tinghao , Hu Anming , Su Rongfeng , Lyu Chengchen , Wang Lan , Yan Nan
Published: December 2021

While a large amount of research has studied the facilitation of visual speech on auditory speech recognition, few have investigated the processing of visual speech gestures in motor‐oriented tasks that focus on the spatial and motor features of the articulator actions instead of the phonetic features of auditory and visual speech. The current study examined the engagement of spatial and phonetic processing of visual speech in a motor‐oriented speech imitation task. Functional near‐infrared spectroscopy (fNIRS) was used to measure the haemodynamic activities related to spatial processing and audiovisual integration in the superior parietal lobe (SPL) and the posterior superior/middle temporal gyrus (pSTG/pMTG) respectively. In addition, visuo‐labial and visuo‐lingual speech were compared with examine the influence of visual familiarity and audiovisual association on the processes in question. fNIRS revealed significant activations in the SPL but found no supra‐additive audiovisual activations in the pSTG/pMTG, suggesting that the processing of audiovisual speech stimuli was primarily focused on spatial processes related to action comprehension and preparation, whereas phonetic processes related to audiovisual integration was minimal. Comparisons between visuo‐labial and visuo‐lingual speech imitations revealed no significant difference in the activation of the SPL or the pSTG/pMTG, suggesting that a higher degree of visual familiarity and audiovisual association did not significantly influence how visuo‐labial speech was processed compared with visuo‐lingual speech. The current study offered insights on the pattern of visual‐speech processing under a motor‐oriented task objective and provided further evidence for the modulation of multimodal speech integration by voluntary selective attention and task objective.
Mathematics in Fashion Programs: Are Graduates Prepared for Today’s Retail Market?
Authors: Enderson Mary C. , Watson Ginger S. , Miles Christina G.
Published: December 2021

Fashion programs are no stranger to mathematics and its importance to the field. This study reports on 205 undergraduate fashion marketing and fashion merchandising students who completed a Mathematics for Industry test used to measure their mathematics abilities. New program students were compared to program completers to see if coursework had any impact on improved scores. Findings revealed no differences except for “numbers and computations” where new program students performed better than program completers. This raised questions on the ability of exiting students to operate successfully in industry and retail markets particularly in areas that have direct connections to mathematics.
A Case Study of Intercultural Competence among Career and Technical Teacher Candidates
Authors: Deaton Sheri , Goering Christian Z.
Published: December 2021

Intercultural competence is defined as an ability to act appropriately in situations where multiple cultures are represented. Few studies have examined the impact that intercultural development activities and reflections have on preservice career and technical education teachers. Grounded in the theory of continual improvement, this study investigated how middle and high school career and technical education teacher candidates grew in their own intercultural competency throughout a four‐month teaching internship. Ten participants completed one survey/questionnaire, one video reflection, one interview, and one writing reflection as part of their semester teaching internship. Three themes emerged from the data analysis including awareness of the outward expressions of diversity, a need for continuous improvement, and a demonstration of flexible and responsive teaching strategies.
Focusing for the Future—Revising the National Standards for Teachers of Family and Consumer Sciences
Authors: Handy Deborah , Turgeson Susan , Shepherd Nancy
Published: December 2021

Family and consumer sciences (FCS) teachers are frequently changing programs to meet the needs of society and their local communities. Preparation for FCS teachers undergoes the same evolution. Teaching standards in family and consumer sciences prepare teachers for the challenges of the classroom. The need to respond to a changing environment prompted teacher educators to review and update the National Standards for Teachers of Family and Consumer Sciences. Standards and competencies were reviewed in teams of stakeholders with justified responses. Changes reflect two new standards, Wellness and Laboratory Management, alignment with Family, Career, and Community Leaders of America (FCCLA), InTASC standards, edTPA assessments, 21st Century Skills, and career and technical education frameworks. Anticipated uses of the Standards cover a range of possibilities from program development and assessment to informing professional development plans.
Efforts in Diversity and Recruiting in Financial Planning Undergraduate Programs
Authors: Reiter Miranda , Kiss D. Elizabeth
Published: December 2021

There is a significant challenge in recruiting those from underrepresented racial and ethnic groups as well as women into financial services careers. Undergraduate financial planning programs serve as an entry point for many financial planning professionals. This qualitative study explored the recruitment efforts and strategies of 37 financial planning undergraduate programs in the United States as well as the current gender and racial representation of students in those programs. Results reveal the challenges of filling the financial advisor pipeline. They also offer insights that can be applied to increase the number of financial planning students and ultimately the number of prospective future financial advisors.
The Influence of Financial Education Sources on Emergency Savings: The Role of Financial Literacy
Authors: Fan Lu , Zhang Lini
Published: December 2021

Using data from the 2018 National Financial Capability Study, this research explored the relationship between financial education sources and emergency savings of U.S. adults, and examined the mediating role of financial literacy. The results showed that receiving financial education from both school and workplace had positive associations with having emergency funds. Financial literacy was found to be positively associated with having emergency funds and financial literacy mediated the relationship between financial education and having emergency savings. The findings reinforced the significance of different financial education sources in increasing the likelihood of saving for emergencies. Implications for policymakers, financial educators and counselors, and employers are included.
Rural Healthcare Providers’ Perceptions of Patient Financial Well‐Being and Integrating Financial Capability Services
Authors: Bartholomae Suzanne , Kiss D. Elizabeth , Collins J. Michael , Johnson Carrie L. , Janney Carol A
Published: December 2021

This exploratory study documents rural healthcare providers’ perspectives on patients’ financial well‐being, and the feasibility of integrating financial capability supports into healthcare services. Surveys (n = 132) and online focus groups (n = 17) in 2019 were used to collect data. Three key findings were that rural healthcare providers: (i) recognize the influence of financial capability on patients’ health outcomes and healthcare access, (ii) saw a need for resources to support patients’ financial capability, and (iii) do not feel well‐positioned to address patients’ financial needs. Implications include the need for tools, resources, partnership strategies, and programs that support rural patients’ financial capability.
Oxytocin variation and brain region‐specific gene expression in a domesticated avian species
Authors: Tobari Yasuko , Theofanopoulou Constantina , Mori Chihiro , Sato Yoshimi , Marutani Momoka , Fujioka Sayaka , Konno Norifumi , Suzuki Kenta , Furutani Akari , Hakataya Shiomi , Yao Cheng‐Te , Yang En‐Yun , Tsai Chia‐Ren , Tang Pin‐Chi , Chen Chih‐Feng , Boeckx Cedric , Jarvis Erich D. , Okanoya Kazuo
Published: December 2021

The Bengalese finch was domesticated more than 250 years ago from the wild white‐rumped munia (WRM). Similar to other domesticated species, Bengalese finches show a reduced fear response and have lower corticosterone levels, compared to WRMs. Bengalese finches and munias also have different song types. Since oxytocin (OT) has been found to be involved in stress coping and auditory processing, we tested whether the OT sequence and brain expression pattern and content differ in wild munias and domesticated Bengalese finches. We sequenced the OT from 10 wild munias and 11 Bengalese finches and identified intra‐strain variability in both the untranslated and protein‐coding regions of the sequence, with all the latter giving rise to synonymous mutations. Several of these changes fall in specific transcription factor‐binding sites, and show either a conserved or a relaxed evolutionary trend in the avian lineage, and in vertebrates in general. Although in situ hybridization in several hypothalamic nuclei did not reveal significant differences in the number of cells expressing OT between the two strains, real‐time quantitative PCR showed a significantly higher OT mRNA expression in the cerebrum of the Bengalese finches relative to munias, but a significantly lower expression in their diencephalon. Our study thus points to a brain region‐specific pattern of neurochemical expression in domesticated and wild avian strains, which could be linked to domestication and the behavioral changes associated with it.
Vasorin deficiency leads to cardiac hypertrophy by targeting MYL7 in young mice
Authors: Sun Junming , Guo Xiaoping , Yu Ping , Liang Jinning , Mo Zhongxiang , Zhang Mingyuan , Yang Lichao , Huang Xuejing , Hu Bing , Liu Jiajuan , Ouyang Yiqiang , He Min
Published: December 2021

Vasorin (VASN) is an important transmembrane protein associated with development and disease. However, it is not clear whether the death of mice with VASN deficiency (VASN−/−) is related to cardiac dysfunction. The aim of this research was to ascertain whether VASN induces pathological cardiac hypertrophy by targeting myosin light chain 7 (MYL7). VASN−/− mice were produced by CRISPR/Cas9 technology and inbreeding. PCR amplification, electrophoresis, real‐time PCR and Western blotting were used to confirm VASN deficiency. Cardiac hypertrophy was examined by blood tests, histological analysis and real‐time PCR, and key downstream factors were identified by RNA sequencing and real‐time PCR. Western blotting, immunohistochemistry and electron microscopy analysis were used to confirm the downregulation of MYL7 production and cardiac structural changes. Our results showed that sudden death of VASN−/− mice occurred 21–28 days after birth. The obvious increases in cardiovascular risk, heart weight and myocardial volume and the upregulation of hypertrophy marker gene expression indicated that cardiac hypertrophy may be the cause of death in young VASN−/− mice. Transcriptome analysis revealed that VASN deficiency led to MYL7 downregulation, which induced myocardial structure abnormalities and disorders. Our results revealed a pathological phenomenon in which VASN deficiency may lead to cardiac hypertrophy by downregulating MYL7 production. However, more research is necessary to elucidate the underlying mechanism.
VLX1570 regulates the proliferation and apoptosis of human lung cancer cells through modulating ER stress and the AKT pathway
Authors: Wang Juan , Du Tongde , Lu Ya , Lv Yan , Du Yuxin , Wu Jianzhong , Ma Rong , Xu Chenxin , Feng Jifeng
Published: December 2021

The ubiquitin‐proteasome system (UPS) possesses unique functions in tumorigenesis and has great potential for targeting tumours. The effectiveness of inhibitors targeting UPS in solid tumours remains to be studied. We screened a library of inhibitors targeting the ubiquitination system and found the highly potent, low‐concentration inhibitor molecule VLX1570 that specifically killed lung cancer cells. VLX1570 is an inhibitor of deubiquitinating enzyme activity and has also shown potential for preclinical cancer treatment. We found that VLX1570 significantly inhibited lung cancer cells proliferation and colony formation. VLX1570 induced a G2/M cell cycle arrest by downregulating CDK1 and CyclinB1. Moreover, VLX1570 significantly promoted the mitochondrial‐associated apoptosis. Mechanistically speaking, VLX1570 activated the PERK/IRE1/ATF6 pathway and induced ER stress in lung cancer cell lines. The inhibition of ER stress by tauroursodeoxycholic acid sodium or 4‐phenylbutyric acid enhanced VLX1570‐induced apoptosis. In addition, VLX1570 treatment led to the inactivation of Akt signalling and inhibited the proliferation of lung cancer cells by downregulating the Akt pathway. Moreover, combined treatment with VLX1570 and Afatinib or Gefitinib induced synergistic anti‐lung cancer activity. Our present study demonstrated a novel therapy using VLX1570, which inhibited the proliferation and increased apoptosis in human lung cancer.
Exosomal hsa_circ_0125310 promotes cell proliferation and fibrosis in diabetic nephropathy via sponging miR‐422a and targeting the IGF1R/p38 axis
Authors: Zhu Yingchun , Zha Fangfang , Tang Bo , Ji Ting‐Ting , Li Xiao‐Ying , Feng Linhong , Bai Shou‐Jun
Published: December 2021

Diabetic nephropathy (DN) is still on the rise worldwide, and millions of patients have to be treated through dialysis or transplant because of kidney failure caused by DN. Recent reports have highlighted circRNAs in the treatment of DN. Herein, we aimed to investigate the mechanism by which high glucose‐induced exo‐circ_0125310 promotes diabetic nephropathy progression. circ_0125310 is highly expressed in diabetic nephropathy and exosomes isolated from high glucose‐induced mesangial cells (MCs). High glucose‐induced exosomes promote the proliferation and fibrosis of MCs. However, results showed that the effects of exosomes on MCs can be reversed by the knockdown of circ_0125310. miR‐422a, which targets IGF1R, was the direct target of circ_0125310. circ_0125310 regulated IGF1R/p38 axis by sponging miR‐422a. Exo‐circ_0125310 increased the luciferase activity of the WT‐IGF1R reporter in the dual‐luciferase reporter gene assays and upregulated the expression level of IGF1R and p38. Finally, in vivo research indicated that the overexpression of circ_0125310 promoted the diabetic nephropathy progression. Above results demonstrated that the high glucose‐induced exo‐circ_0125310 promoted cell proliferation and fibrosis in diabetic nephropathy via sponging miR‐422a and targeting the IGF1R/p38 axis.
Human adipose tissue–derived mesenchymal stromal cells and their phagocytic capacity
Authors: Costela Ruiz Víctor J. , Melguizo Rodríguez Lucía , Illescas Montes Rebeca , García Recio Enrique , Arias Santiago Salvador , Ruiz Concepción , De Luna Bertos Elvira
Published: December 2021

Mesenchymal stromal cells (MSCs) have evidenced considerable therapeutic potential in numerous clinical fields, especially in tissue regeneration. The immunological characteristics of this cell population include the expression of Toll‐like receptors and mannose receptors, among others. The study objective was to determine whether MSCs have phagocytic capacity against different target particles. We isolated and characterized three human adipose tissue MSC (HAT‐MSC) lines from three patients and analysed their phagocytic capacity by flow cytometry, using fluorescent latex beads, and by transmission electron microscopy, using Escherichia coli, Staphylococcus aureus and Candida albicans as biological materials and latex beads as non‐biological material. The results demonstrate that HAT‐MSCs can phagocyte particles of different nature and size. The percentage of phagocytic cells ranged between 33.8% and 56.2% (mean of 44.37% ± 11.253) according to the cell line, and a high phagocytic index was observed. The high phagocytic capacity observed in MSCs, which have known regenerative potential, may offer an advance in the approach to certain local and systemic infections.
Development of thoracic sarcoid reactions associated with complete response to anti‐PD‐1 therapy in a patient with advanced cutaneous squamous cell carcinoma
Authors: Gambichler T. , Philippou S. , Scheel C.H. , Susok L.
Published: December 2021

In patients with advanced cutaneous squamous cell carcinoma (cSCC), positive efficacy data were reported for anti‐PD‐1 antibodies. However, anti‐PD‐1 treatment is associated with a wide range of immune‐related adverse events (irAEs). Here, we report on a 78‐year‐old woman with a huge cSCC on the right cheek spanning from the temporal to the cervical region with evidence for infiltration of the parotid gland, right masseter muscle and right auditory canal. Ultrasound revealed cervical, submandibular and supraclavicular lymph node metastases on patient’s right side. On the basis of a medical hardship application, treatment with pembrolizumab was initiated. After two applications, a dramatic regression of the tumour was observed. At this point, the patient was switched to cemiplimab, which, in the meantime, had become available in Germany. After 3 months on cemiplimab, the tumour‐related ulcer on the right cheek showed almost complete regression and all previously affected lymph nodes displayed no evidence for malignancy. Thoracic computed tomography (CT) scans revealed enlarged mediastinal and bilateral hilar lymph nodes assessed as primarily reactive. Three months later, however, mediastinal and bilateral hilar lymph nodes further increased in size, accompanied by radiological alterations of the lung parenchyma. Lymph node biopsies revealed sarcoid reactions (SRs) including fibrotic non‐caseating epitheloid cell granulomas surrounded by lymphocytes. Since the patient did not display any clinical symptoms, cemiplimab treatment was continued following a 4‐week break. Three months later, CT showed significant regression of the described enlarged lymph nodes and parenchymal lung changes. Twenty months after anti‐PD‐1 treatment, the patient was still in complete remission. In conclusion, we describe, for the first time, the case of a patient with advanced cSCC who developed disseminated thoracic SRs which were associated with dramatic regression of tumour masses. Thus, as with other irAEs, development of SRs might be indicative of an anti‐tumour response to anti‐PD‐1 therapy.
Common things are common, but what is common? Incorporating probability information into differential diagnosis
Authors: Aberegg Scott K. , Callahan Sean J.
Published: December 2021

The well‐known clinical axiom declaring that ‘common things are common’ attests to the pivotal role of probability in diagnosis. Despite the popularity of this and related axioms, there is no operationalized definition of a common disease, and no practicable way of incorporating actual disease frequencies into differential diagnosis. In this essay, we aim to disambiguate the definition of a common (or rare) disease and show that incidence—not prevalence—is the proper metric of disease frequency for differential diagnosis. We explore how numerical estimates of disease frequencies based on incidence can be incorporated into differential diagnosis as well as the inherent limitations of this method. These concepts have important implications for diagnostic decision making and medical education, and hold promise as a method to improve diagnostic accuracy.
Iron accumulation is associated with periodontal destruction in a mouse model of HFE‐related haemochromatosis
Authors: Han Pingping , Liu Tianqing , Vaquette Cedryck , Frazer David , Anderson Gregory , Ivanovski Sašo
Published: December 2021

Objective

To investigate the effect of Hfe gene mutation on the distribution of iron and periodontal bone loss in periodontal tissues.

Background data

It remains unclear how tissue iron loading affects the periodontium architectures in a genetic animal model of hereditary haemochromatosis (HH).

Methods

Male C57BL/6 Hfe
−/− (8 weeks old) and wild‐type (WT) mice were utilized to examine the iron distribution in periodontal tissues, as well as periodontal tissues changes using micro‐computed tomography and histomorphometric analysis. Furthermore, tissue inflammatory mediators, bone markers and periodontal pathogens were carried out in PFA‐fixed paraffin‐embedded tissues using ELISA, RT‐qPCR and genomic DNA qPCR, respectively.

Results

Excessive iron deposition was found in the periodontal ligament, gingiva and alveolar bone in Hfe
−/− mice relative to their WT counterparts. This, in turn, was associated with significant periodontal bone loss, increased cemento‐enamel junction‐alveolar bone crest distance and decreased expression of molecules involved in bone development and turnover. Furthermore, the pro‐inflammatory cytokine ‐ interleukin 6 and periodontal bacteria – Campylobacter rectus were significantly increased in Hfe
−/− mice compared with WT controls.

Conclusion

Our results suggest that the iron loading in a mouse model of HH decreases alveolar bone formation and leads to alterations in the inflammatory state in the periodontium. Periodontal health should be assessed during the clinical assessment of HFE‐HH patients.
Association between hyperlipidemia and calcium oxalate lower urinary tract uroliths in dogs
Authors: Paulin Mathieu V , Dunn Marilyn , Vachon Catherine , Beauchamp Guy , Conversy Bérénice
Published: December 2021

Background

Metabolic syndrome is associated with formation of calcium oxalate (CaOx) uroliths in humans.

Objectives

To investigate the association between obesity and hyperlipidemia with CaOx lower urinary tract uroliths in client‐owned dogs.

Animals

Dogs with (n = 55, U [uroliths]‐dogs) and without (n = 39, UF [uroliths‐free]‐dogs) CaOx lower urinary tract uroliths.

Methods

Case‐control study. U‐dogs were retrospectively enrolled and compared to UF‐dogs. Body condition score (BCS; 1‐9 scoring scale), serum triglyceride (TG) and total cholesterol (CH) concentrations and glycemia (after >12‐hour food withholding) were recorded in both groups.

Results

On univariate logistic regression, when excluding Miniature Schnauzers, odds of having uroliths increased by a factor of 3.32 (95% CI 1.38‐11.12) for each mmol/L of TG (P = .027), of 39 (95% CI 9.27‐293.22) for each mmol/L of glycemia (P < .0001), and of 2.43 (95% CI 1.45‐4.45) per unit of BCS (P = .002). In multivariable models, the effect of TG was retained when all breeds were included for analysis and odds of having uroliths increased by a factor of 4.34 per mmol/L of TG (95% CI 1.45‐19.99; P = .02).

Conclusions and Clinical Importance

Serum lipid screening in dogs diagnosed with CaOx uroliths might be recommended to improve their medical staging and management.
Crotalaria gajureliana (Fabaceae: Papilionoideae): a new species from Maharashtra, India with glandular seeds
Authors: Gholave Avinash Ramchandra , Madhav Nilesh Appaso , Gosavi Kumar Vinod Chhotupuri , Kambale Sharad Suresh
Published: December 2021

The new species Crotalaria gajureliana is described and illustrated. It was found in the Nashik district, Maharashtra state, India. Crotalaria gajureliana is a member of C. sect. Calycinae subsect. Diffusae and it is closely related to C. filipes. However, the presence of hyaline, irregularly shaped glands throughout the seeds makes it unique within the genus. A key to the species of C. subsect. Diffusae in India is provided to facilitate identification.
The impact of stay‐at‐home policies on individual welfare*
Authors: Andersson Ola , Campos‐Mercade Pol , Carlsson Fredrik , Schneider Florian H. , Wengström Erik
Published: December 2021

In this paper, we perform a choice experiment assessing the impact of stay‐at‐home policies on individual welfare. We estimate the willingness to accept compensation (WTA) for restricting non‐working hours in Sweden during the COVID‐19 pandemic. The WTA for a one‐month stay‐at‐home policy is about US$480 per person, or 9.1 percent of Sweden's monthly per capita GDP. Stricter lockdowns require disproportionately higher compensation than more lenient ones, indicating that strict policies are cost‐effective only if they are much more successful in slowing the spread of the disease. Moreover, older people have a higher WTA of staying home than the rest of the population.
Impact of Complex Fracture Networks on Rate Transient Behavior of Wells in Unconventional Reservoirs Based on Embedded Discrete Fracture Model
Authors: Qin Jiazheng , Xu Yingjie , Tang Yong , Liang Rui , Zhong Qianhu , Yu Wei , Sepehrnoori Kamy
Published: December 2021

It has recently been demonstrated that complex fracture networks (CFNs) especially activated natural fractures (ANF) play an important role in unconventional reservoir development. However, traditional rate transient analysis (RTA) methods barely investigate the impact of CFN or ANF. Furthermore, the influence of CFN on flow regime is still ambiguous. Failure to consider these effects could lead to misdiagnosis of flow regimes and underestimation of original oil in place (OOIP). A novel numerical RTA method is therefore presented herein to improve the quality of reserves assessment. A new methodology is introduced. Propagating hydraulic fractures (HFs) can generate different stress perturbations to allow natural fractures (NFs) to fail, forming various ANF patterns. An embedded discrete fracture model (EDFM) of ANF is stochastically generated instead of local grid refinement (LGR) method to overcome the time-intensive computation time. These models are coupled with reservoir models using non-neighboring connections (NNCs). Results show that except for simplified models used in previous studies subjected to the traditional concept of stimulated reservoir volume (SRV); in our study, the ANF region has been discussed to emphasis the impact of NF on simulation results. Henceforth, ANF could be only concentrated around the near-wellbore region, and it may also cover the whole simulation area. Obvious distinctions could be viewed for different kinds of ANF on diagnostic plots. Instead of SRV-dominated flow mentioned in previous studies, ANF-dominated flow developed in this work is shown to be more reasonable. Also, new flow regimes such as interference flow inside and outside activated natural fracture flow region (ANFR) are found. In summary, better evaluation of reservoir properties and reserves assessment such as OOIP are achieved based on our proposed model compared with conventional models. The novel RTA method considering CFN presented herein is an easy-to-apply numerical RTA technique that can be applied for reservoir and fracture characterization as well as OOIP assessment.
Potential Role of Plyometric Training in the Development of Motor Performance Skills: A Narrative Review
Authors: Sortwell Andrew , Newton Michael , Marinho Daniel A. , Knijnik Jorge , Ramirez-Campillo Rodrigo
Published: December 2021

Offering children chances to optimize their engagement in physical activities during their life span is one of the major aims of school physical education (PE). To this end, the maximum development of motor performance skills can help primary school children participate in various physical activities throughout their lives. The purpose of this review was to examine the effects of plyometric training activities on motor performance skills of children and the application of plyometrics within the PE setting. Relevant studies on the topics of motor performance skills, plyometrics, athlete development, and motor development in children and adolescents were examined. The paper reveals that plyometric training activities can improve motor performance skills such as running, jumping, and kicking. The literature also suggests that children’s exposure to plyometric exercises may result in an accelerated improvement in primary school PE class. This review concludes with a proposal to enhance children’s motor performance skills using plyometric exercises in primary PE classes.
Detecting mid-infrared light by molecular frequency upconversion in dual-wavelength nanoantennas
Authors: Xomalis Angelos , Zheng Xuezhi , Chikkaraddy Rohit , Koczor-Benda Zsuzsanna , Miele Ermanno , Rosta Edina , Vandenbosch Guy A. E. , Martínez Alejandro , Baumberg Jeremy J.
Published: December 2021

Optomechanical upconversion

Molecules have rich signatures in their spectra at infrared wavelengths and are typically accessed with dedicated spectroscopic instrumentation. Chen
et al
. and Xomalis
et al
. report optomechanical frequency upconversion from the mid-infrared to the visible domain using molecular vibrations coupled to a plasmonic nanocavity at ambient conditions (see the Perspective by Gordon). Using different nanoantenna designs, one with a nanoparticle-on-resonator and the other with nanoparticle-in-groove, both approaches show the ability to upconvert the mid-infrared vibrations of the molecules in the nanocavity to visible light wavelengths. The effect could be used to simplify infrared spectroscopy, possibly with single-molecule sensitivity. —ISO
Continuous-wave frequency upconversion with a molecular optomechanical nanocavity
Authors: Chen Wen , Roelli Philippe , Hu Huatian , Verlekar Sachin , Amirtharaj Sakthi Priya , Barreda Angela I. , Kippenberg Tobias J. , Kovylina Miroslavna , Verhagen Ewold , Martínez Alejandro , Galland Christophe
Published: December 2021

Optomechanical upconversion

Molecules have rich signatures in their spectra at infrared wavelengths and are typically accessed with dedicated spectroscopic instrumentation. Chen
et al
. and Xomalis
et al
. report optomechanical frequency upconversion from the mid-infrared to the visible domain using molecular vibrations coupled to a plasmonic nanocavity at ambient conditions (see the Perspective by Gordon). Using different nanoantenna designs, one with a nanoparticle-on-resonator and the other with nanoparticle-in-groove, both approaches show the ability to upconvert the mid-infrared vibrations of the molecules in the nanocavity to visible light wavelengths. The effect could be used to simplify infrared spectroscopy, possibly with single-molecule sensitivity. —ISO
Coding-Complete Sequences of Recombinant Lumpy Skin Disease Viruses Collected in 2020 from Four Outbreaks in Northern Vietnam
Authors: Mathijs Elisabeth , Vandenbussche Frank , Nguyen Long , Aerts Laetitia , Nguyen Tho , De Leeuw Ilse , Quang Minh , Nguyen Hoang Dang , Philips Wannes , Dam Thi Vui , Haegeman Andy , Van Borm Steven , De Clercq Kris
Published: December 2021

Lumpy skin disease virus
(LSDV) causes a severe, systemic, and economically important disease in cattle. Here, we report coding-complete sequences of recombinant LSDVs from four outbreaks in October and November 2020 in northeastern Vietnam.
Whole-Genome Sequence of Oryctes rhinoceros Nudivirus from Riau Province, Indonesia
Authors: Kurnia Yudistira Wahyu , Tanjung Zulfikar Achmad , Utomo Condro , Naim Mohammad , Situmorang Elizabeth Caroline , Liwang Tony
Published: December 2021

A double-stranded DNA virus,
Oryctes rhinoceros
nudivirus (OrNV), was detected in the total DNA of diseased larvae of
O. rhinoceros
in Riau Province, Indonesia. The complete genome sequence was 124,926 bp long and encodes 123 open reading frames (ORFs). This strain belongs to the family
Nudiviridae
and was designated LiboV.
Supplemental Material: Methane seeps as refugia during ash falls in the Late Cretaceous Western Interior Seaway of North America
Authors: Brophy Shannon K. , al. et
Published: December 2021

Additional information on sample collection and stratigraphy of the site, faunal analysis and data standardization, and stable isotope analysis, and supplemental tables of raw and transformed datasets.
Association between interpregnancy interval and pregnancy complications by history of complications: a population-based cohort study
Authors: Gebremedhin Amanuel Tesfay , Tessema Gizachew Assefa , Regan Annette K , Pereira Gavin F
Published: December 2021

Objective

To examine if the association between interpregnancy interval (IPI) and pregnancy complications varies by the presence or absence of previous complications.

Design and setting

Population-based longitudinally linked cohort study in Western Australia (WA).

Participants

Mothers who had their first two (n=252 368) and three (n=96 315) consecutive singleton births in WA between 1980 and 2015.

Outcome measures

We estimated absolute risks (AR) of preeclampsia (PE) and gestational diabetes (GDM) for 3–60 months of IPI according to history of each outcome. We modelled IPI using restricted cubic splines and reported adjusted relative risk (RRs) with 95% CI at 3, 6, 12, 24, 36, 48 and 60 months, with 18 months as reference.

Results

Risks of PE and GDM were 9.5%, 2.6% in first pregnancies, with recurrence rates of 19.3% and 41.5% in second pregnancy for PE and GDM, respectively. The AR of GDM ranged from 30% to 43% across the IPI range for mothers with previous GDM compared with 2%–8% for mothers without previous GDM. For mothers with no previous PE, greater risks were observed for IPIs at 3 months (RR 1.24, 95% CI 1.07 to 1.43) and 60 months (RR 1.40, 95% CI 1.29 to 1.53) compared with 18 months. There was insufficient evidence for increased risk of PE at shorter IPIs of <18 months for mothers with previous PE. Shorter IPIs of <18 months were associated with lower risk than at IPIs of 18 months for mothers with no previous GDM.

Conclusions

The associations between IPIs and risk of PE or GDM on subsequent pregnancies are modified by previous experience with these conditions. Mothers with previous complications had higher absolute, but lower RRs than mothers with no previous complications. However, IPI remains a potentially modifiable risk factor for mothers with previous complicated pregnancies.
Determination of pharmacy students’ patient safety approach using the theory of planned behaviour: a mixed-method study
Authors: Rajiah Kingston , Maharajan Mari Kannan , Chong David , Chiao Chien Shee , Li Eileen Ong Xiao
Published: December 2021

Objectives

To investigate pharmacy students’ attitudes, subjective norms, perceived behavioural control, intentions and their behaviour towards patient safety using a theory of planned behaviour framework.

Design

Mixed-methods research.

Setting

Private university in Malaysia.

Participants

Pharmacy undergraduate students participated in the study. There were 18 students participated in the qualitative study and 272 students responded to the survey questionnaire.

Methods

A convergent parallel-mixed method design, involving a quantitative survey and qualitative focus group discussions was used among pharmacy students in a private university in Malaysia. Qualitative data of transcribed verbatim texts were then subjected to a thematic content analysis framework. Multiple correlations were undertaken using the quantitative data to examine how the dependent variable (self-reported knowledge) related to the independent variables (attitudes, behavioural intentions, subjective norms, perceived behavioural control.

Primary outcome

Pharmacy students’ attitudes, subjective norms, perceived behavioural control, behavioural intentions constructs led to their behaviour towards patient safety.

Secondary outcome

The quantitative study revealed that there was a moderate positive correlation between students’ self-reported knowledge and attitudes (r=0.48, p=0.03).

Results

Pharmacy students’ attitudes and perceived behavioural control constructs had positive correlations with pharmacy students’ self-reported knowledge on patient safety. There was no correlation between students’ self-reported knowledge and subjective norms (r=0.27, p=0.23). There was a weak positive correlation between students’ self-reported knowledge and perceived behavioural control (r=0.39, p=0.04). There was no correlation between students’ self-reported knowledge and behavioural intention (r=0.20, p=0.56).

Conclusions

Theory of planned behaviour constructs such as attitudes, subjective norms, perceived behavioural control and behavioural intentions of pharmacy students, defined their behaviour towards patient safety. Pharmacy students’ attitudes and perceived behavioural control constructs were correlated with their self-reported knowledge on patient safety.
Nominal group technique to establish the core components of home-based rehabilitation for survivors of stroke with severe disability
Authors: Fisher Rebecca J , Riley-Bennett Frances , Russell Lal , Lee Claire , Sturt Ruth , Walker Marion , Sackley Cath
Published: December 2021

In the UK, over 20% of patients leaving hospital after a stroke will be severely disabled. Despite this, limited clinical guidance is available to teams tasked with providing support for this complex population at home. Additionally, many areas across the UK are not commissioned to treat this patient cohort, leaving them with no specialist support on discharge.

Objectives

To establish core components of home-based rehabilitation for survivors of stroke with severe disability, based on expert panel consensus.

Setting

Virtual nominal group technique (vNGT) across the UK.

Participants

Experts in the field of stroke rehabilitation (n=14) including researchers, clinicians and those with lived experience.

Methods

Two vNGT were completed using a freely available online platform, Microsoft Teams. The technique’s five stages were completed virtually; introduction, silent idea generation, round robin, clarifications and scoring. Statements were analysed for consensus, those achieving consensus underwent content analysis to form rich overarching consensus statements.

Results

A combined total of 421 statements achieved positive consensus (>75% in agreement), which formed 11 overarching consensus statements. These outline key components of home-based rehabilitation for survivors of stroke with severe disability including the structure and members of the team, as well as the skills and knowledge required.

Conclusion

The consensus statements highlight the complexity of managing patients with severe stroke disability following discharge from hospital. This study has the potential to support the provision of services for this patient group, providing a benchmark for commissioners and clinicians as well as setting expectations for stroke survivors and their carers. What remains unknown is how many services currently offer this service to patients with severe disability.