bluuebunny/crossref_metadata_2025 huggingface dataset:
Use of Honey Bees and Hive Products as Bioindicators to Assess Environmental Contamination in Targeted Areas of the Campania Region (Italy)
Authors: Catalano Patrizio , Della Sala Francesco , Cavaliere Maria , Caputo Carla , Pecoraro Domenico , Crispino Giulia , Lettera Stefania , Caioni Giulia , Esposito Mauro , Verre Antonio , Castellone Luigi , Bianco Enrico , Amorena Michele
Published: May 2024

In recent years, biomonitoring has gained more attention, particularly when assessing the environmental health of significant areas, such as those near waste-to-energy facilities. These requirements coincide with the chance to detect environmental pollutants using sensitive organisms. Bees were shown to be quite effective in evaluating the presence of certain compounds by analyzing their associated matrices, such as pollen, honey, or wax. In our study, we employed the honey bee (Apis mellifera) as an indicator to initially monitor the vicinity of the waste-to-energy plant in Acerra, which is situated in the Campania region of Italy. The primary aim was to determine whether the facility was accountable for any environmental releases of dioxins or dioxin-like compounds. Then, we assessed the presence of additional pollutants in the same area, including trace elements, polycyclic aromatic hydrocarbons, and pesticides, released by human activities. To obtain further information about environmental quality, a second biomonitoring station was installed near the Caivano S.T.I.R. (Waste Shredding, Sifting, and Packaging Plant). The results showed the dioxin levels did not exceed predetermined limitations at the Acerra site, thus demonstrating the efficacy of the waste-to-energy facility and the bees’ ability to detect the presence of other pollutants. Additionally, this biomonitoring system exhibited sensitivity to environmental variations, thereby enabling the evaluation of xenobiotic flux between two proximate zones and across temporal scales. This pioneering study suggests the advantages of utilizing bees to detect a wide range of contaminants, thereby providing valuable insights into environmental quality and potential health risks for both ecosystems and human populations.
Fecal Microbial Communities of Nellore and Crossbred Beef Calves Raised at Pasture
Authors: Bessegatto José Antônio , Lisbôa Júlio Augusto Naylor , Santos Bruna Parapinski , Curti Juliana Massitel , Montemor Carlos , Alfieri Amauri Alcindo , Mach Núria , Costa Marcio Carvalho
Published: May 2024

This study aimed to investigate the effect of age and genetics on the fecal microbiota of beef calves. Ten purebred Nellore (Bos taurus indicus) and ten crossbreed 50% Nellore-50% European breed (Bos taurus taurus) calves co-habiting on the same pasture paddock had fecal samples collected on days five (5 d), 14 d, 28 d, 60 d, 90 d, 180 d, 245 d (weaning) and 260 d after birth. All calves were kept with their mothers, and six Nellore dams were also sampled at weaning. Microbiota analysis was carried out by amplification of the V4 region of the 16S rRNA gene following high-throughput sequencing with a MiSeq Illumina platform. Results revealed that bacterial richness increased with age and became more similar to adults near weaning. Differences in microbiota membership between breeds were found at 60 d and 90 d and for structure at 60 d, 90 d, 245 d, and 260 d (p < 0.05). In addition, crossbreed calves presented less variability in their microbiota. In conclusion, the genetic composition significantly impacted the distal gut microbiota of calves co-habiting in the same environment, and further studies investigating food intake can reveal possible associations between microbiota composition and performance.
A Review of the Rumen Microbiota and the Different Molecular Techniques Used to Identify Microorganisms Found in the Rumen Fluid of Ruminants
Authors: Silva Éder Bruno Rebelo da , Silva Jamile Andréa Rodrigues da , Silva Welligton Conceição da , Belo Tatiane Silva , Sousa Carlos Eduardo Lima , Santos Maria Roseane Pereira dos , Neves Kedson Alessandri Lobo , Rodrigues Thomaz Cyro Guimarães de Carvalho , Camargo-Júnior Raimundo Nonato Colares , Lourenço-Júnior José de Brito
Published: May 2024

Variations in environments, including climate, diet, and agricultural practices, significantly impact the composition and microbial activity. A profound understanding of these adaptations allows for the improvement of nutrition and ruminant production. Therefore, this review aims to compile data from the literature on the rumen microbiota and molecular techniques for identifying the different types of microorganisms from the rumen fluid of ruminants. Analyzing the literature on rumen microbiology in different ruminants is complex due to microbial interactions, influenced by the environment and nutrition of these animals. In addition, it is worth noting that the genera of protozoa and fungi most evident in the studies used in this review on the microbiology of rumen fluid were Entodinium spp. and Aspergillus spp., respectively, and Fibrobacter spp. for bacteria. About the techniques used, it can be seen that DNA extraction, amplification, and sequencing were the most cited in the studies evaluated. Therefore, this review describes what is present in the literature and provides an overview of the main microbial agents in the rumen and the molecular techniques used.
A Study on Mineral Oil Hydrocarbons (MOH) Contamination in Pig Diets and Its Transfer to Back Fat and Loin Tissues
Authors: Albendea Paula , Conchione Chiara , Menegoz Ursol Luca , Moret Sabrina
Published: May 2024

This study assessed saturated mineral oil hydrocarbons (MOSH) and aromatic mineral oil hydrocarbons (MOAH) levels in grower–finisher feeds for pigs supplemented with 5% crude palm oil (CP), crude olive pomace oil (COP), olive pomace acid oil (OPA), or a blend of CP and OPA (50:50, w/w); the contribution of the lipid source to that contamination; and the ability of pigs to accumulate MOH in back fat and loin tissues after 60 days of trial. MOSH and MOAH were analyzed with liquid chromatography (LC)–gas chromatography (GC)–flame ionization detection (FID) after sample preparation. Among the lipid sources, CP had the lowest MOH levels, but CP feeds showed the highest contamination. This, along with the different MOSH profiles, indicated the presence of more significant contamination sources in the feeds than the lipid source. The higher MOH contamination in CP feeds was reflected in the highest MOSH levels in pig back fat, whereas MOAH were not detected in animal tissues. Also, MOSH bioaccumulation in pig tissues was influenced by the carbon chain length. In conclusion, feed manufacturing processes can determine the MOSH contamination present in animal adipose tissues that can be included in human diets.
Assessment of Suitable Habitat of the Demoiselle Crane (Anthropoides virgo) in the Wake of Climate Change: A Study of Its Wintering Refugees in Pakistan
Authors: Khan Tauheed Ullah , Ullah Inam , Hu Yiming , Liang Jianchao , Ahmad Shahid , Omifolaji James Kehinde , Hu Huijian
Published: May 2024

The inevitable impacts of climate change have reverberated across ecosystems and caused substantial global biodiversity loss. Climate-induced habitat loss has contributed to range shifts at both species and community levels. Given the importance of identifying suitable habitats for at-risk species, it is imperative to assess potential current and future distributions, and to understand influential environmental factors. Like many species, the Demoiselle crane is not immune to climatic pressures. Khyber Pakhtunkhwa and Balochistan provinces in Pakistan are known wintering grounds for this species. Given that Pakistan is among the top five countries facing devastating effects of climate change, this study sought to conduct species distribution modeling under climate change using data collected during 4 years of field surveys. We developed a Maximum Entropy distribution model to predict the current and projected future distribution of the species across the study area. Future habitat projections for 2050 and 2070 were carried out using two representative concentration pathways (RCP 4.5 and RCP 8.5) under three global circulation models, including HADGEM2-AO, BCC-CSM1-1, and CCSM4. The most influential factors shaping Demoiselle Crane habitat suitability included the temperature seasonality, annual mean temperature, terrain ruggedness index, and human population density, all of which contributed significantly to the suitability (81.3%). The model identified 35% of the study area as moderately suitable (134,068 km2) and highly suitable (27,911 km2) habitat for the species under current climatic conditions. Under changing climate scenarios, our model predicted a major loss of the species’ current suitable habitat, with shrinkage and shift towards western–central areas along the Pakistan–Afghanistan boarder. The RCP 8.5, which is the extreme climate change scenario, portrays particularly severe consequences, with habitat losses reaching 65% in 2050 and 85% in 2070. This comprehensive study provides useful insights into the Demoiselle Crane habitat’s current and future dynamics in Pakistan.
Parameter Estimation in Spatial Autoregressive Models with Missing Data and Measurement Errors
Authors: Li Tengjun , Zhang Zhikang , Song Yunquan
Published: May 2024

This study addresses the problem of parameter estimation in spatial autoregressive models with missing data and measurement errors in covariates. Specifically, a corrected likelihood estimation approach is employed to rectify the bias in the log-maximum likelihood function induced by measurement errors. Additionally, a combination of inverse probability weighting (IPW) and mean imputation is utilized to mitigate the bias caused by missing data. Under several mild conditions, it is demonstrated that the proposed estimators are consistent and possess oracle properties. The efficacy of the proposed parameter estimation process is assessed through Monte Carlo simulation studies. Finally, the applicability of the proposed method is further substantiated using the Boston Housing Dataset.
Quasi-Contraction Maps in Subordinate Semimetric Spaces
Authors: Alharbi Areej , Alsulami Hamed , Noorwali Maha
Published: May 2024

Throughout this study, we discuss the subordinate Pompeiu–Hausdorff metric (SPHM) in subordinate semimetric spaces. Moreover, we present a well-behaved quasi-contraction (WBQC) to solve quasi-contraction (QC) problems in subordinate semimetric spaces under some local constraints. Furthermore, we provide examples to support our conclusion.
Strategic Behavior and Optimal Inventory Level in a Make-to-Stock Queueing System with Retrial Customers
Authors: Wang Yuejiao , Cai Chenguang
Published: May 2024

In this article, we consider a make-to-stock queueing system with retrial customers. Upon their arrival, customers make a decision to either join the system or not based on a reward–cost function. If customers join the retrial queue, they become repeat customers. Each repeat customer repeats their demand after an exponential amount of time until they have been successfully served. We explore the equilibrium strategies of customers in both the almost observable and unobservable cases. Furthermore, we also analyze the expected costs of the entire system based on the customers’ behavior in these two cases. Additionally, we determine the optimal inventory levels in both cases through numerical experiments.
Stability of the Borell–Brascamp–Lieb Inequality for Multiple Power Concave Functions
Authors: Qin Meng , Zhang Zhuohua , Luo Rui , Ren Mengjie , Wu Denghui
Published: May 2024

In this paper, we prove the stability of the Brunn–Minkowski inequality for multiple convex bodies in terms of the concept of relative asymmetry. Using these stability results and the relationship of the compact support of functions, we establish the stability of the Borell–Brascamp–Lieb inequality for multiple power concave functions via relative asymmetry.
Quasi-Configurations Derived by Special Arrangements of Lines
Authors: Innamorati Stefano
Published: May 2024

A quasi-configuration is a point–line incidence structure in which each point is incident with at least three lines and each line is incident with at least three points. We investigate derived quasi-configurations that arise both by duality and intersecting lines of three special arrangements of lines. Sets with few intersection numbers are provided.
Optimizing Structural Patterns for 3D Electrodes in Lithium-Ion Batteries for Enhanced Fast-Charging Capability and Reduced Lithium Plating
Authors: Sterzl Yannic , Pfleging Wilhelm
Published: May 2024

The most common pattern types for anode structuring, in particular the line, grid, and hexagonal-arranged hole pattern were evaluated in a comparable setup in full-cells and symmetrical cells. The cells with structured electrodes were compared to reference cells with unstructured anodes of similar areal capacity (4.3 mAh cm−2) and the onset of lithium plating during fast-charging was determined in situ by differential voltage analysis of the voltage relaxation and ex situ by post-mortem analysis. Furthermore, electrochemical impedance spectroscopy measurements on symmetrical cells were used to determine the ionic resistance of structured and unstructured electrodes of similar areal capacity. All cells with structured electrodes showed lower ionic resistances and an onset of lithium plating shifted to higher C-rates compared to cells with unstructured electrodes. The structure patterns with capillary structures, i.e., lines and grids, showed significant reduced lithium plating during fast-charging and a higher rate capability compared to reference cells with unstructured electrodes and cells with hole structured electrodes. The continuous rewetting of the electrode with liquid electrolyte by capillary forces and the reduced ionic resistance of the 3D electrode are identified as key factors in improving overall battery performance. The data of the studied cells were used to calculate the resulting energy and power densities of prospective commercial pouch cells and potential pitfalls in the comparison to cells with unstructured electrodes were identified.
Impact of Storage Temperature on Green Tea Quality: Insights from Sensory Analysis and Chemical Composition
Authors: Zhao Xi , Yu Penghui , Zhong Ni , Huang Hao , Zheng Hongfa
Published: May 2024

This study investigated the impact of storage temperatures (−20 °C, room temperature, and 40 °C) on the sensory evaluation, metabolites, and volatile compounds of green tea stored for 12 months. The sensory evaluation revealed that tea samples stored at −20 °C retained their emerald green colour, tender aroma, and refreshing taste. Green tea biochemical constituents, including water extracts and total free amino acids, were measured by Chinese National Standard Methods (GB/T 8305-2013 and GB/T 8314-2013). Tea polyphenols and flavonoids were determined using spectrophotometric methods, while phytochemicals were detected using validated HPLC, and volatile compounds were detected using validated gas chromatography coupled with triple quadrupole mass spectrometry. The analysis showed that tea polyphenols were highest at −20 °C, and flavonoids were significantly reduced at higher temperatures. A similar trend was observed for amino acids, soluble sugar content, and water extracts. Tea catechins, including (-)-epigallocatechin-3-gallate (EGCG) and (-)-gallocatechin gallate (GCG), were highest at −20 °C, showing their susceptibility to temperature. A volatile compound analysis revealed distinct profiles with variations in the abundance of compounds, such as di-methyl sulfide, phenyl ethyl alcohol, indole, and benzaldehyde. This study identifies temperature-sensitive compounds, providing insights into the mechanisms underlying tea quality deterioration during storage.
Response Mechanism of cbbM Carbon Sequestration Microbial Community Characteristics in Different Wetland Types in Qinghai Lake
Authors: Zhang Ni , Chen Kelong , Wang Xinye , Ji Wei , Yang Ziwei , Wang Xia , Li Junmin
Published: May 2024

Carbon-sequestering microorganisms play an important role in the carbon cycle of wetland ecosystems. However, the response mechanism of carbon-sequestering microbial communities to wetland type changes and their relationship with soil carbon remain unclear. To explore these differences and identify the main influencing factors, this study selected marsh wetlands, river wetlands and lakeside wetlands around Qinghai Lake as research subjects. High-throughput sequencing was employed to analyze the functional gene cbbM of carbon-sequestering microorganisms. The results revealed that the alpha diversity of cbbM carbon-sequestering microorganisms mirrored the trend in total carbon content, with the highest diversity observed in marsh wetlands and the lowest in lakeside wetlands. The dominant bacterial phylum was Proteobacteria, with prevalent genera including Thiothrix, Acidithiobacillus, and Thiodictyon. Acidithiobacillus served as a biomarker in lakeside wetlands, while two other genera were indicative of marsh wetlands. The hierarchical partitioning analysis indicated that the diversity of cbbM carbon-fixing microorganisms was primarily influenced by the total nitrogen content, while the community structure was significantly affected by the soil total carbon content. Moreover, an increased soil temperature and humidity were found to favor the carbon fixation processes of Thiomicrospira, Thiomonas, Polaromonas, and Acidithiobacillus. In summary, changes in wetland types seriously affected the characteristics of cbbM carbon sequestration in microbial communities, and a warm and humid climate may be conducive to wetland carbon sequestration.
Sleep-like State in Pond Snails Leads to Enhanced Memory Formation
Authors: Namiki Kengo , Nakai Junko , Lukowiak Ken , Ito Etsuro
Published: May 2024

To test the hypothesis that a sleep-like quiescent state enhances memory consolidation in the pond snail Lymnaea stagnalis, we interposed a period in which snails experienced either a quiescent, sleeping state or an active, non-sleeping state following escape behavior suppression learning (EBSL). During EBSL training, the number of escapes made by a snail from a container was significantly suppressed using an external aversive stimulus (punishment). After training, the snails were divided into two groups. One group of snails was allowed to move freely and to experience a sleep-like quiescent state for 3 h in distilled water. The other group was stimulated with a sucrose solution every 10 min to keep them active (i.e., non-sleeping). In the memory test, escape behavior was suppressed in the group that experienced the quiescent state, whereas the suppression was not observed in snails that were kept active. Additionally, the latency of the first escape in the memory test was shorter in the snails kept active than in those that experienced the quiescent state. Together, these data are consistent with the hypothesis that a sleep-like quiescent state enhances EBSL memory consolidation in L. stagnalis.
A Dangerous Couple: Sequential Effect of Phosphorus Flame-Retardant and Polyurethane Decrease Locomotor Activity in Planarian Girardia tigrina
Authors: Bjedov Dora , Barbosa Rone S. , Oliveira Danielle Palma de , Dorta Daniel Junqueira , Sarmento Maíra Ignacio , Sarmento Renato Almeida , Silva Ana L. Patrício , Gravato Carlos
Published: May 2024

Understanding the interplay among organophosphorus flame retardants (OPFRs), microplastics, and freshwater organisms is crucial for unravelling the dynamics within freshwater environments and foreseeing the potential impacts of organic pollutants and plastic contamination. For that purpose, the present research assessed the exposure impact of 10 mg L−1 flame-retardant aluminium diethylphosphinate (ALPI), 10 μg mg−1liver microplastics polyurethane (PU), and the combination of ALPI and PU on the freshwater planarian Girardia tigrina. The exposure to both ALPI and PU revealed a sequential effect, i.e., a decrease in locomotor activity, while oxidative stress biomarkers (total glutathione, catalase, glutathione S-transferase, lipid peroxidation) and metabolic responses (cholinesterase activity, electron transport system, and lactate dehydrogenase) remained unaffected. Despite this fact, it was possible to observe that the range of physiological responses in exposed organisms varied, in particular in the cases of the electron transport system, cholinesterase activity, glutathione S-transferase, catalase, and levels of total glutathione and proteins, showing that the energetic costs for detoxification and antioxidant capacity might be causing a lesser amount of energy allocated for the planarian activity. By examining the physiological, behavioural, and ecological responses of planarians to these pollutants, insights can be gained into broader ecosystem-level effects and inform strategies for mitigating environmental risks associated with OPFRs and microplastic pollution in freshwater environments.
Special Issue: “Neurodegenerative Diseases: Recent Advances and Future Perspectives”
Authors: López-Cuenca Inés , De Hoz Rosa
Published: May 2024

Neurodegenerative diseases include a heterogeneous group of conditions that pose a growing challenge to public health and the scientific community [...]
A Decade of Dedication: Pioneering Perspectives on Neurological Diseases and Mental Illnesses
Authors: Tanaka Masaru , Vécsei László
Published: May 2024

Welcome to Biomedicines’ 10th Anniversary Special Issue, a journey through the human mind’s labyrinth and complex neurological pathways [...]
Highly Sensitive Qualitative and Quantitative Identification of Cashmere and Wool Based on Terahertz Electromagnetically Induced Transparent Metasurface Biosensor
Authors: Luo Dongpeng , Xu Limin , Jia Lifeng , Cheng Lianglun , Tang Ping , Zhou Jinyun
Published: May 2024

Cashmere and wool are both natural animal fibers used in the textile industry, but cashmere is of superior quality, is rarer, and more precious. It is therefore important to distinguish the two fibers accurately and effectively. However, challenges due to their similar appearance, morphology, and physical and chemical properties remain. Herein, a terahertz electromagnetic inductive transparency (EIT) metasurface biosensor is introduced for qualitative and quantitative identification of cashmere and wool. The periodic unit structure of the metasurface consists of four rotationally symmetric resonators and two cross−arranged metal secants to form toroidal dipoles and electric dipoles, respectively, so that its effective sensing area can be greatly improved by 1075% compared to the traditional dipole mode, and the sensitivity will be up to 342 GHz/RIU. The amplitude and frequency shift changes of the terahertz transmission spectra caused by the different refractive indices of cashmere/wool can achieve highly sensitive label−free qualitative and quantitative identification of both. The experimental results show that the terahertz metasurface biosensor can work at a concentration of 0.02 mg/mL. It provides a new way to achieve high sensitivity, precision, and trace detection of cashmere/wool, and would be a valuable application for the cashmere industry.
Variable Pressure Difference Control Method for Chilled Water System Based on the Identification of the Most Unfavorable Thermodynamic Loop
Authors: Chen Tingting , Han Yuhang
Published: May 2024

A variable pressure differential fuzzy control method is proposed based on the online identification method for key parameters and the fuzzy subset inference fuzzy control method of the chilled water system network model. Firstly, a phase plane fuzzy identification method is proposed for the most unfavorable thermal loop. The study focuses on analyzing the trend of room temperature deviation and deviation change in different quadrants in the phase plane. Furthermore, we establish a chilled water pipe network model that recalculates flow variation in both the main pipe and each branch pipe section to eliminate the most unfavorable thermal loop. Finally, the test platform for the fan coil variable flow air conditioning water system was designed and constructed to meet the requirements of energy-saving regulation. Additionally, the network monitoring system for the test platform was completed. The calibration and debugging results demonstrate that the monitoring error is within ±5.0%, ensuring precise control of room temperature at the end of the branch within ±0.5 °C. Results demonstrate that our novel method exhibits superior stability in room temperature control compared to traditional linear variable pressure differential set point controls while achieving energy saving ranging from 4.7% to 6.5%.
Study on the Performance Evolution of Hydraulic Concrete under the Alternating Action of Freeze–Thaw and Abrasion
Authors: Wu Baoguo , Li Shuangxi , Jiang Chunmeng
Published: May 2024

The hydraulic concrete in the alpine region is subjected to alternating actions of freeze–thaw (F) and abrasion (W) during operation, resulting in significant deterioration of concrete durability. In this paper, the water/binder ratio (W/B) was employed as the test variable, the working condition F group and W group were set as the control group, and the working condition F-W group was used as the test group. Fast-freezing and underwater methods are used for the alternating test. By measuring the mass loss, relative dynamic elastic modulus (RDEM), surface morphological characteristics, fractal dimension of concrete in each alternating cycle, and the evolution law of concrete performance under the alternating action of F and W was explored. The results show that compared with the control group, the alternating action will accelerate the mass loss of concrete, reduce the RDEM, and cause the deterioration of surface wear. The maximum increase in mass loss and RDEM of concrete is 1.92% and 20.11%, respectively. During this process, the fractal dimension of the concrete increases as the number of alternating cycles increases, but it still does not exceed the limit of 2.4. In addition, a relationship function between the fractal dimension and the mass loss rate, volume loss, was established. It was found that the experimental group had a good linear correlation, and the correlation was close to 95%, which was about 20% higher than that of the control group.
Assessing Traffic Noise and Its Impact on High-Rise Apartment Buildings Adjacent to an Urban Expressway: A Case Study in Chengdu, China
Authors: Yu Heng , Li Ailing
Published: May 2024

With rapid urbanization, traffic growth has accelerated in some cities in China. Due to strict urban construction land utilization policies, many high-rise apartment buildings have been constructed adjacent to expressways. To better understand the impact of urban traffic noise on the residents of high residential buildings adjacent to expressways and the differences in noise impacts on different floors, on-site noise monitoring and questionnaires for building residents have been conducted. The characteristics of traffic noise were analyzed based on the measured data, and factors, including time periods and building floors, were considered. According to the results of the questionnaire survey, 56.06% of the male respondents and 54.55% of the female respondents think that the impact of traffic noise on high-rise buildings is “high” or “very high”; 50.53% of the respondents who were in “good” or “very good” condition thought that the traffic noise has a “significant impact” or “very significant impact” on their sleep and daily life. In addition, 25% of respondents living on floors 4–10 and 62.5% of respondents living on floors 11–20 considered the traffic noise to have a “significant impact” or “very significant impact” on their sleep and daily life. The on-site noise monitoring results show that the noise levels (LAeq) outside the windows of the studied buildings remain significantly elevated, with daytime noise on working days ranging from 56 to 70 dB(A), and on weekends ranging from 50 to 65 dB(A). During the four time periods on weekdays from 7 a.m. to 9 a.m., 11 a.m. to 1 p.m., 5 p.m. to 7 p.m., and 10 p.m. to 12 a.m., the average LAeq levels on floors 11–20 are higher than those on floors 4–10 by 4.04 dB(A), 4.92 dB(A), 4.06 dB(A), and 2.67 dB(A), respectively. Similarly, during these time periods on weekends, the levels on floors 11–20 are higher than those on floors 4–10 by 4.96 dB(A), 6.32 dB(A), 5.28 dB(A), and 5.24 dB(A), respectively. This indicates that floors 4–10 of the building experience relatively lower noise levels, while floors 11–20 are subjected to comparatively higher levels of noise disturbance.
Adaptability and Interconnectedness in Latin American Innerburbs: An Assessment of the Public/Private Interface in Informal Settlements
Authors: Muñoz Carlos Augusto Martínez , Ramos Francisco Javier Maroto
Published: May 2024

An “Innerburb” is an urban structure that emerged between the 1950s and 1980s, settled in rural areas, and is considered the first periphery of the Latin American city. This structure results from socio-spatial and territorial evolutionary processes, constituting the pinnacle of informal evolution. However, despite offering a comprehensive perspective on the informal problem, innerburbs have been scarcely reviewed in the literature. This article explores the Latin American innerburb by adopting as a method a comparative study of the public/private interface in the cases of San Cosme in Lima, Villa Rodolfo Ricciardelli in Buenos Aires and Vila Heliopolis in São Paulo, evaluating their adaptation and interconnection with the city through morphological indicators, using morphological mapping through satellite images as an analytical tool, and using Space Syntax as a topological approach in the analysis of connectivity and visibility indicators. The objective of the research is the detection of morphological patterns that alter the functioning of the public/private interface in innerburbs. The results show that the existence of impermeable facades, the lack of public spaces and the illegal appropriation in the development of informal practices are transgressive adaptability patterns at the micro-scale that affect the interface, drastically limiting the interconnection between the innerburb and the formal fabric, restricting its morphological openness and affecting the development of socioeconomic activities. As a discussion and conclusion, corrective measures for progressive improvement in innerburbs are established, focusing on the adaptability of housing and road space as a means of interconnection between the innerburb and the city.
Microstructure and Phase Characterization of Alkali-Activated Slag–Fly Ash Materials with Tetrasodium of 1-Hydroxy Ethylidene-1, 1-Diphosphonic Acid (HEDP·4Na)
Authors: Zhou Bo , Zhang Mingyang , Zhang Jiaqing , Wei Jingjie
Published: May 2024

The effect of tetrasodium of 1-hydroxy ethylidene-1, 1-diphosphonic acid (HEDP·4Na) on the microstructure and phase characterization of alkali-activated fly ash–slag (AAFS) materials is not clear or well documented. In this study, XRD, DTG, TAM-air, and SEM analyses of AAFS were used to identify the microstructural changes in AAFS made with HEDP·4Na. Meanwhile, the workability and compressive strength of AAFS were evaluated. The results demonstrated that the early-age alkaline-activated reactions were retarded due to the addition of HEDP·4Na in the AAFS mixture. However, the degree of gel formation was relatively increased at a later age in the AAFS made with HEDP·4Na compared to the plain AAFS mixture. Additionally, in comparison to the control group, the incorporation of HEDP·4Na in AAFS specimens resulted in improved flowability, with increments of 5%, 15%, and 24% for concentrations of 0.1%, 0.2%, and 0.3%, respectively. The initial and final setting times were prolonged by 5% to 50%, indicating a beneficial impact on the rheological properties of the AAFS fresh mixture. Furthermore, the addition of HEDP·4Na led to an improvement in compressive strength in the AAFS mixtures, with enhancements ranging from 13% to 16% at 28 days compared to the control group. With the presence of HEDP·4Na, the increase in the degree of reactions shifted to the formation of gel phases, like C-S-H, through the combined measurement of TGA, XRD, and SEM, resulting in a denser microstructure in the AAFS matrix. This study presents novel insights into the intricate compatibility between the properties of AAFS mixtures and HEDP·4Na, facilitating a more profound comprehension of the potential improvements in the sustainable development of AAFS systems.
Study on the Anti-Progressive Collapse Behavior of Steel Frame Structures under Close-Range Blast Loading
Authors: Ke Changren , Long Huihui , Jiang Junling
Published: May 2024

The steel frame structure plays an important role in strategic deployments and is widely used in heavy machinery, metallurgy, military, and other important industries. To study the impact of explosive loads on the anti-progressive collapse performance of steel structures, this paper proposes to establish the vulnerability characteristics of steel frame structures and provides a method for calculating vulnerability characterization indicators. A finite element model is used to analyze the dynamic response of steel frame structures under the action of close-range explosive loads, and factors influencing the anti-progressive collapse of steel frame structures are proposed, including the number of stories and diagonal bracing. A comparison is made between the various column types of steel structures under explosive loads, such as corner columns, long-edge middle columns, short-edge middle columns, inner columns, also in various coupling conditions. The results show that the progressive collapse of steel frame structures is greatly influenced by the position of the explosion and less affected by the amount of explosive material. The simultaneous failure of corner columns and long-edge middle columns is more likely to cause overall structural failure. The addition of diagonal bracing significantly improves the anti-progressive collapse ability and prevents the lateral displacement of steel frame structures; increasing the number of stories provides more alternative load transfer paths for steel frame structures, thereby preventing their collapse.
Prognostic Significance of the Royal Marsden Hospital (RMH) Score in Patients with Cancer: A Systematic Review and Meta-Analysis
Authors: Sahin Taha Koray , Rizzo Alessandro , Aksoy Sercan , Guven Deniz Can
Published: May 2024

Background: Cancer remains a leading cause of death globally, necessitating the identification of prognostic biomarkers to guide treatment decisions. The Royal Marsden Hospital (RMH) score, based on readily available blood tests and clinical features, has emerged as a prognostic tool, although its performance across variable clinical scenarios is not thoroughly delineated. Therefore, we aimed to systematically assess the association between RMH score and survival in cancer patients. Methods: We conducted a systematic literature search across Pubmed, Scopus, and Web of Science databases for studies published up to 15 February 2024. We performed a meta-analysis with the generic inverse variance method with a random-effects model and reported hazard ratios (HR) with 95% confidence intervals (CI). Results: Nineteen studies encompassing 127,230 patients were included. A higher RMH score was significantly associated with worse overall survival (OS) (HR: 2.09, 95% CI: 1.87–2.33, p < 0.001) and progression-free survival (PFS) (HR: 1.80, 95% CI: 1.48–2.18, p < 0.001). This association was consistent across various subgroups, including study population (clinical trial vs. real-world cohort), geographic region, and tumor type. Conclusion: This meta-analysis, including over a hundred thousand patients, demonstrates a negative association between a higher RMH score and survival in cancer patients. The RMH score holds promise as a readily available prognostic tool across diverse cancer types and clinical settings. Future research should focus on validating and refining this score to aid clinical decision-making.
Osteosarcoma Arising as a Secondary Malignancy following Treatment for Hematologic Cancer: A Report of 33 Affected Patients from the Cooperative Osteosarcoma Study Group (COSS)
Authors: Bielack Stefan S. , Mettmann Vanessa , Baumhoer Daniel , Blattmann Claudia , Burkhardt Birgit , Deinzer Christoph K. W. , Kager Leo , Kevric Matthias , Mauz-Körholz Christine , Müller-Abt Peter , Reinhardt Dirk , Sabo Alexandru-Anton , Schrappe Martin , Sorg Benjamin , Windhager Reinhard , Hecker-Nolting Stefanie
Published: May 2024

Purpose: Osteosarcoma may arise as a secondary cancer following leukemias or lymphomas. We intended to increase the knowledge about such rare events. Patients and methods: We searched the Cooperative Osteosarcoma Study Group’s database for individuals who developed their osteosarcoma following a previous hematological malignancy. The presentation and treatment of both malignancies was investigated, and additional neoplasms were noted. Outcomes after osteosarcoma were analyzed and potential prognostic factors were searched for. Results: A total of 33 eligible patients were identified (male: 23, female: 10; median age: 12.9 years at diagnosis of hematological cancer; 20 lymphomas, 13 leukemias). A cancer predisposition syndrome was evident in one patient only. The hematological cancers had been treated by radiotherapy in 28 (1 unknown) and chemotherapy in 26 cases, including bone-marrow transplantation in 9. The secondary bone sarcomas (high-grade central 27, periosteal 2, extra-osseous 2, undifferentiated pleomorphic sarcoma of bone 2) arose after a median lag-time of 9.4 years, when patients were a median of 19.1 years old. Tumors were considered radiation-related in 26 cases (1 unknown). Osteosarcoma-sites were in the extremities (19), trunk (12), or head and neck (2). Metastases at diagnosis affected eight patients. Information on osteosarcoma therapy was available for 31 cases. All of these received chemotherapy. Local therapy involved surgery in 27 patients, with a good response reported for 9/18 eligible patients. Local radiotherapy was given to three patients. The median follow-up was 3.9 (0.3–12.0) years after bone tumor diagnosis. During this period, 21 patients had developed events as defined, and 15 had died, resulting in 5-year event-free and overall survival rates of 40% (standard error: 9%) and 56% (10%), respectively. There were multiple instances of additional neoplasms. Several factors were found to be of prognostic value (p < 0.05) for event-free (osteosarcoma site in the extremities) or overall (achievement of a surgical osteosarcoma-remission, receiving chemotherapy for the hematologic malignancy) survival. Conclusions: We were able to prove radiation therapy for hematological malignancies to be the predominant risk factor for later osteosarcomas. A resulting overrepresentation of axial and a tendency towards additional neoplasms affects prognosis. Still, selected patients may become long-term survivors with appropriate therapies, which is an argument against therapeutic negligence.
Treatment Modalities for Non-Muscle Invasive Bladder Cancer: An Updated Review
Authors: McNall Shannon , Hooper Kailey , Sullivan Travis , Rieger-Christ Kimberly , Clements Matthew
Published: May 2024

The landscape of treatment for non-muscle invasive bladder cancer is rapidly changing. A complete and careful transurethral resection is the mainstay of initial treatment and is followed by intravesical therapy in intermediate or high-risk cases. The standard of care is intravesical BCG. Many alternative or additive approaches to this are being explored. We divided this review into three relevant spaces to consider these novel treatment approaches: (1) low-risk disease, for which intravesical therapy is not usually considered, (2) BCG-naïve disease (i.e., considering alternatives to the standard therapy), and (3) BCG-unresponsive disease. We performed a review of published literature and summarized ongoing trials in the United States. Novel approaches that we explored include surgical techniques for resection, alterations in dwell time for intravesical therapy, delivery method and schedule of intravesical therapies, new intravesical therapy agents, and systemic therapies (especially immunotherapy). These are thoroughly outlined throughout this review article, and the numerous modalities being studied demonstrate significant promise for the future treatment of the expanding space of NMIBC.
Glucose-to-Lymphocyte Ratio (GLR) as an Independent Prognostic Factor in Patients with Resected Pancreatic Ductal Adenocarcinoma—Cohort Study
Authors: Park Su-Hyeong , Kang In-Cheon , Hong Seung-Soo , Kim Ha-Yan , Hwang Ho-Kyoung , Kang Chang-Moo
Published: May 2024

Background: We retrospectively evaluated the usefulness of an elevated glucose-to-lymphocyte ratio (GLR) as a sensitive prognostic biomarker of disease-specific survival in 338 patients who underwent surgical resection of pancreatic ductal adenocarcinoma (PDAC). Methods: The optimal GLR cutoff value was determined using the method of Contal and O’Quigley. Patient demographics, clinical information, and imaging data were analyzed to identify preoperative predictors of long-term survival outcomes. Results: Elevated GLR correlated significantly with aggressive tumor biologic behaviors, such as a high carbohydrate antigen (CA) 19-9 level (p = 0.003) and large tumor size (p = 0.011). Multivariate analysis identified (1) GLR > 92.72 [hazard ratio (HR) = 2.475, p < 0.001], (2) CA 19-9 level > 145.35 (HR = 1.577, p = 0.068), and (3) symptoms (p = 0.064) as independent predictors of long-term, cancer-specific survival. These three risk factors were used to group patients into groups 1 (0 factors), 2 (1–2 factors), and 3 (3 factors), which corresponded to significantly different 5-year overall survival rates (50.2%, 34.6%, and 11.7%, respectively; p < 0.001). Conclusions: An elevated preoperative GLR is associated with aggressive tumor characteristics and is an independent predictor of poor postoperative prognosis in patients with PDAC. Further prospective studies are required to verify these findings.
Risk Prediction, Diagnosis and Management of a Breast Cancer Patient with Treatment-Related Cardiovascular Toxicity: An Essential Overview
Authors: Cronin Michael , Lowery Aoife , Kerin Michael , Wijns William , Soliman Osama
Published: May 2024

Breast cancer is amongst the most common invasive cancers in adults. There are established relationships between anti-cancer treatments for breast cancer and cardiovascular side effects. In recent years, novel anti-cancer treatments have been established, as well as the availability of multi-modal cardiac imaging and the sophistication of treatment for cardiac disease. This review provides an in-depth overview regarding the interface of breast cancer and cancer therapy-related cardiovascular toxicity. Specifically, it reviews the pathophysiology of breast cancer, the method of action in therapy-related cardiovascular toxicity from anti-cancer treatment, the use of echocardiography, cardiac CT, MRI, or nuclear medicine as diagnostics, and the current evidence-based treatments available. It is intended to be an all-encompassing review for clinicians caring for patients in this situation.
Targets in the Tumour Matrisome to Promote Cancer Therapy Response
Authors: Jalil Siti Munira Abd , Henry Jack C. , Cameron Angus J. M.
Published: May 2024

The extracellular matrix (ECM) is composed of complex fibrillar proteins, proteoglycans, and macromolecules, generated by stromal, immune, and cancer cells. The components and organisation of the matrix evolves as tumours progress to invasive disease and metastasis. In many solid tumours, dense fibrotic ECM has been hypothesised to impede therapy response by limiting drug and immune cell access. Interventions to target individual components of the ECM, collectively termed the matrisome, have, however, revealed complex tumour-suppressor, tumour-promoter, and immune-modulatory functions, which have complicated clinical translation. The degree to which distinct components of the matrisome can dictate tumour phenotypes and response to therapy is the subject of intense study. A primary aim is to identify therapeutic opportunities within the matrisome, which might support a better response to existing therapies. Many matrix signatures have been developed which can predict prognosis, immune cell content, and immunotherapy responses. In this review, we will examine key components of the matrisome which have been associated with advanced tumours and therapy resistance. We have primarily focussed here on targeting matrisome components, rather than specific cell types, although several examples are described where cells of origin can dramatically affect tumour roles for matrix components. As we unravel the complex biochemical, biophysical, and intracellular transduction mechanisms associated with the ECM, numerous therapeutic opportunities will be identified to modify tumour progression and therapy response.
Daratumumab during Myeloma Induction Therapy Is Associated with Impaired Stem Cell Mobilization and Prolonged Post-Transplant Hematologic Recovery
Authors: Mehl Julian , Akhoundova Dilara , Bacher Ulrike , Jeker Barbara , Rhyner Agocs Gaëlle , Ruefer Axel , Soltermann Susanne , Soekler Martin , Winkler Annette , Daskalakis Michael , Pabst Thomas
Published: May 2024

Daratumumab is being increasingly integrated into first-line multiple myeloma (MM) induction regimens, leading to improved response depth and longer progression-free survival. Autologous stem cell transplantation (ASCT) is commonly performed as a consolidation strategy following first-line induction in fit MM patients. We investigated a cohort of 155 MM patients who received ASCT after first-line induction with or without daratumumab (RVd, n = 110; D-RVd, n = 45), analyzing differences in stem cell mobilization, apheresis, and engraftment. In the D-RVd group, fewer patients successfully completed mobilization at the planned apheresis date (44% vs. 71%, p = 0.0029), and more patients required the use of rescue plerixafor (38% vs. 28%, p = 0.3052). The median count of peripheral CD34+ cells at apheresis was lower (41.37 vs. 52.19 × 106/L, p = 0.0233), and the total number of collected CD34+ cells was inferior (8.27 vs. 10.22 × 106/kg BW, p = 0.0139). The time to recovery of neutrophils and platelets was prolonged (12 vs. 11 days, p = 0.0164; and 16 vs. 14 days, p = 0.0002, respectively), and a higher frequency of erythrocyte transfusions (74% vs. 51%, p = 0.0103) and a higher number of platelet concentrates/patients were required (4 vs. 2; p = 0.001). The use of daratumumab during MM induction might negatively impact stem cell mobilization and engraftment in the context of ASCT.