bluuebunny/crossref_metadata_2025 huggingface dataset:
Protocol of Pakistan randomized and observational trial to evaluate coronavirus treatment among newly diagnosed patients with COVID-19: Azithromycin, Oseltamivir, and Hydroxychloquine
Authors: Azhar Shehnoor , Akram Javed , Shahzad Muhammad , Latif Waqas , Khan Khalid Saeed
Published: May 2022

Background & Objective: This study aimed to assess the clinical effectiveness of Hydroxychloroquine Sulfate (200 mg orally 8 hourlies thrice a day for 5 days), oseltamivir (75 mg orally twice a day for 5 days), and Azithromycin (500 mg orally daily on day 1, followed by 250 mg orally twice a day on days 2-5) alone and in combination (in seven groups).

Methods & Analysis: An adaptive design is deployed, set within a comprehensive cohort study, to permit flexibility in fast-changing clinical and public health scenario. Primary outcomes include turning the test negative for coronavirus nucliec acid and in bringing about clinical improvement on day 7 of follow-up on a seven-point ordinal scale. The randomized study will recruit participants of either gender above 18 years of age who will test positive for SARS-CoV-2 on Quantitative Reverse Transcription Polymerase Chain Reaction (PCR). Pregnant or lactating females, and those with severe respiratory distress, or with serious comorbidities will be excluded. Randomization will be done maintaining concealment of allocation sequence using a computer-generated random number list. The sample size will be subjected to periodic reviews by National Data Safety and Monitoring Board.

Ethics and Dissemination: The trial is approved by the National Bioethics Committee (No.4-87/NBC-471-COVID-19-05/20/) and institutional Ethical Review Committee. This clinical trial conducted under Good Clinical Practice is expected to inform patients clinical guidelines for the use of these drugs in newly diagnosed with SARS-CoV-2.

Trial Registration: The trial was prospectively registered on April 08, 2020 at clinicaltrials.gov with ID: NCT04338698

doi: https://doi.org/10.12669/pjms.38.5.5512

How to cite this:Azhar S, Akram J, Shahzad M, Latif W, Khan KS. Protocol of Pakistan randomized and observational trial to evaluate coronavirus treatment among newly diagnosed patients with COVID-19: Azithromycin, Oseltamivir, and Hydroxychloquine. Pak J Med Sci. 2022;38(5):---------. doi: https://doi.org/10.12669/pjms.38.5.5512

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Congenital cytomegaly infection - current reports on prevention, diagnosis and effective therapy
Authors: Wacławska Monika , Wacławska Marcelina , Wieteska Małgorzata , Maj Dominik
Published: May 2022

Congenital CMV-cCMV- infection is the most common congenital viral infection in the world, especially in developing countries. It is a serious problem because it can contribute to the development of severe neurodevelopmental disorders and is also the main cause of sensorineural hearing loss. A high risk of adverse effects on the fetus occurs with CMV infection in early pregnancy, but infection can be transmitted from mother to fetus also in cases of secondary infections. Despite the high prevalence of up to 2% of all births, screening for CMV has not yet been established and diagnostic and therapeutic strategies have not been standardized. The aim of this article is to review the current reports on the early detection of congenital CMV, as well as effective methods of its prevention and the best treatment.

Unfortunately, the literature review shows that there are no preventive measures other than proper hygiene during pregnancy. However, many clinical trials are currently underway to develop a CMV effective vaccine. Currently, the infection can be detected already at the stage of fetal life using PCR tests detecting the genetic material of the virus in the amniotic fluid. However, the treatment of already diagnosed congenital CMV is based on antiviral therapy for a period of 12 months, but only in symptomatic infants due to side effects such as neutropenia. Currently, the effectiveness of such treatment reduces the percentage of children with hearing loss and neurological disorders. Pregnant mothers should be educated on how to prevent infections, and doctors' task is to update data on the latest diagnostic and therapeutic recommendations.
‘It's not you; it's us!’: the relevance of mental health team psychodynamics to the care of individuals with complex emotional needs
Authors: Haslam Michael B , Ellis Sue , Plumridge Marcia
Published: May 2022

As the support for trauma-informed approaches and awareness of the power imbalances within the caring relationship are increased, this article proposes that it is time to revisit the issue of team dynamics and their potential impact on responses to individuals with complex emotional needs. Considered through the dual lens of psychodynamic theory and complexity, and using the role of the psychiatric liaison nurse to illustrate points made, it is argued that mental health teams have the potential to experience intense emotions and anxieties that arise from systemic conflict, reflecting the inner experience of individuals to whom they deliver care. Where these anxieties are not contained and remain unresolved, teams may resort to using primary defence mechanisms to protect themselves, potentially leading to invalidating responses and care that is retraumatising. Recommendations to enhance team effectiveness and to mitigate the potential preventable harms that might occur because of team dynamics are discussed.
A Skill Application Model to Improve Teacher Competence and Professionalism
Authors: Farihin Farihin , Suteja Suteja , Muslihudin Muslihudin , Aris Aris , Haqq Arif Abdul , Winarso Widodo
Published: May 2022

Teacher professionalism is needed for quality education. The current practice for increasing teacher professionalism is to use skill applications. However, the implementation of skill applications has, in fact, not succeeded in significantly increasing teacher professionalism. This study aims to explain the importance of an effective skill application model coupled with a comprehensive approach to raise the level of teacher competence. This study is qualitative with its data derived from observations, interviews, and questionnaires. The paper's research findings show that existing programs are not sufficiently enhancing teacher competencies and professionalism. Various teacher professional development activities are conducted; however, there has been no continuous post-activity follow-up. These professional development activities tend only to fulfill the administrative requirements for teacher promotion. What is needed is a comprehensive and continuous teacher professionalism assessment model, which is underpinned by a system of mentoring. This study has implications for evaluating the teacher's professional competencies. More comprehensive skill applications need to be formulated as part of an integrated, sustainable, and mentoring [terpadu, sustainable, pendampingan-TSP] approach to develop teacher professionalism significantly.
The Development of Life Skill Education Evaluation Model at Life Skill Training Centre
Authors: Subarkah Edi , Kartowagiran Badrun , Sumarno Sumarno , Hamdi Syukrul , Rahim Abdul
Published: May 2022

This research aims to develop the product of the life skill education program (LSEP) which is accurate, credible, and effective. This research used the Plomp model. The model covers the input, process, output, outcome and consists of instrument, scoring guidance, and good or bad criteria. The instruments used in the model are the questionnaire, observation sheet and interview guide. The content validity of the questionnaire and observation sheet was proved by expert judgement and continued by using the Aiken Formula, the construct validity of the questionnaire was proved by the construct validity using the exploratory factor analysis (EFA) and confirmatory factor analysis (CFA). The content validity of the questionnaire and observation sheet involved 9 validity experts. The questionnaire construct was done in two steps; the first step involved 65 students analyzed using EFA and the second step involved 199 students analyzed with CFA. The reliability of the observation sheet and questionnaire was estimated by using the Cronbach Alpha technique. The result of the trial model and its analysis shows that all the instruments are good. LSEP model is tested by involving 15 students in the course and training institute. The result of the trial model shows that the model is effective because the users explains that the model is: a) comprehensive, covering many components and sub component programs such as the input, process, output, outcome, b) practical, simple and easy in usage, c) economical, not needing much cost, energy, and time, also d) supported by valid and reliable data collection instrument.
A critical analysis of the MOBI-Kids study of wireless phone use in childhood and adolescence and brain tumor risk
Authors: Hardell Lennart , Moskowitz Joel M.
Published: May 2022

The MOBI-Kids case-control study on wireless phone use and brain tumor risk in childhood and adolescence included the age group 10–24 years diagnosed between 2010 and 2015. Overall no increased risk was found although for brain tumors in the temporal region an increased risk was found in the age groups 10–14 and 20–24 years. Most odds ratios (ORs) in MOBI-Kids were <1.0, some statistically significant, suggestive of a preventive effect from RF radiation; however, this is in contrast to current knowledge about radiofrequency (RF) carcinogenesis. The MOBI-Kids results are not biologically plausible and indicate that the study was flawed due to methodological problems. For example, not all brain tumor cases were included since central localization was excluded. Instead, all brain tumor cases should have been included regardless of histopathology and anatomical localization. Only surgical controls with appendicitis were used instead of population-based controls from the same geographical area as for the cases. In fact, increased incidence of appendicitis has been postulated to be associated with RF radiation which makes selection of control group in MOBI-Kids questionable. Start of wireless phone use up to 10 years before diagnosis was in some analyses included in the unexposed group. Thus, any important results demonstrating late carcinogenesis, a promoter effect, have been omitted from analysis and may underestimate true risks. Linear trend was in some analyses statistically significant in the calculation of RF-specific energy and extremely low frequency (ELF)-induced current in the center of gravity of the tumor. Additional case-case analysis should have been performed. The data from this study should be reanalyzed using unconditional regression analysis adjusted for potential confounding factors to increase statistical power. Then all responding cases and controls could be included in the analyses. In sum, we believe the results as reported in this paper seem uninterpretable and should be dismissed.
Identification of a cytisine-based EED-EZH2 protein-protein interaction inhibitor preventing metastasis in triple-negative breast cancer cells
Authors: Cheng Shasha , Yang Guan-Jun , Wang Wanhe , Song Ying-Qi , Ko Chung-Nga , Han Quanbin , Ma Dik-Lung , Leung Chung-Hang
Published: May 2022

Enhancer of zeste homolog 2 (EZH2) is activated in breast cancer, particularly in triple-negative breast cancer (TNBC), and is critical for cell invasion. It interacts with embryonic ectoderm development (EED) in maintaining cancer stem cells (CSC) and epithelial-mesenchymal transition (EMT) properties, hence promoting CSC metastasis. Because the association of EZH2 with EED promotes the catalytic activity of EZH2, inhibiting the EED-EZH2 interaction is a potential therapeutic strategy for treating EZH2-dependent cancer. Although several EED-EZH2 protein-protein interaction (PPI) inhibitors have been developed, few target EED. Here, we identified that a cytisine derivative compound (1) potently binds EED, thus blocking the EED-EZH2 PPI. Compound 1 was found to inhibit cell proliferation and suppress the growth of 3D tumor spheres of TNBC cells. Moreover, by reversing EMT and decreasing the ratio of CSCs, the compound inhibited TNBC metastasis and invasion ability. Therefore, targeting EED to disrupt the EED-EZH2 PPI may provide a new approach for treating TNBC metastasis. To our knowledge, compound 1 is the first cytisine-based EED-EZH2 PPI inhibitor preventing metastasis in TNBC cells. This study may provide a new avenue for the development of more efficacious EED-EZH2 PPI inhibitors in TNBC treatment.
When Choosing Implies Losing: Does Flipping a Coin Increase Forfeiture Thoughts?
Authors: Jaffé Mariela E. , Douneva Maria , Greifeneder Rainer
Published: May 2022

When individuals choose between two options, one strategy they can apply is flipping a coin. Individuals might follow the coin’s suggestion without further thought. Another possibility is that they take advantage of the change in perspective that the random and clear suggestion affords. We here hypothesize that a coin flip increases forfeiture thoughts by making it salient that choosing one option means forgoing the other. We further expect more forfeiture thoughts when the coin flip’s outcome is incongruent with existing preferences. We conducted two studies (total N = 310) and found evidence that a coin flip suggestion increases forfeiture thoughts compared to a control group without a suggestion. Moreover, we found some evidence that a coin flip suggestion that is incongruent (vs. congruent) with initial preferences increases forfeiture thoughts. Congruency (vs. incongruency) also results in stronger feelings of validation. We follow up on these findings by suggesting a preregistered study that investigates both forfeiture and acquisition thoughts as well as confidence as a downstream consequence of the change initiated by the coin flip. Results, however, do not show that receiving a suggestion (neither congruent or incongruent) impacts forfeiture or acquisition thoughts compared to a control condition. Receiving a congruent (vs. incongruent) suggestion, however, results in stronger feelings of validation. We discuss these different result patterns and potential directions for future research.
Different Variation of Intra-familial Body Mass Index subjected to Covid-19 Lockdown
Authors: Faienza Maria Felicia , Colaianni Valentina , Di Ciaula Agostino , Bonfrate Laonilde , Urbano Flavia , Chiarito Mariangela , Brunetti Giacomina , Giordano Paola , Corbo Filomena , D'Amato Gabriele , Portincasa Piero
Published: May 2022

Background and Aims: Coronavirus disease 2019 (COVID-19) lockdown has represented an inedited model of increased metabolic risk in all age groups, due to negative changes in dietary habits, physical activity, lifestyle. These effects have been generally explored at a population level in distinct age groups. Potential intra-familial, specific effects in adults and children sharing the same socio-economic, cultural level and living habits have been scarcely explored. We aimed to characterize changes of anthropometric indices in parents and in their children during COVID-19 lockdown.

Methods: A cohort of 149 couple parent/children were prospectively enrolled. By a validated questionnaire we explored changes of body mass index (BMI) and individual lifestyle during a 2-month lockdown (May- July 2020).

Results: BMI increased in 70.5% of parents and in 67.8% of their children, with a Δ-BMI of 1.44+0.09 kg/ m 2 and 0.36+0.02 Kg/m 2 , respectively. BMI increments, however, were only significant in adults and did not correlate in the couple parents/children. Most adults (80.5%) and children (71.4%) did not perform regular physical activity during the lockdown. Direct correlations between dietary changes and BMI variations became evident in children, mainly in terms of a decreased consumption of fresh fruit, pulses, fish, and an increased consumption of cereals, carbohydrates, dairy products, olive oil. In normal weight, overweight and obese children, but not in adults, the increase in sleep hours increased with BMI.

Conclusions: Despite marked lifestyle changes imposed by the COVID-19 lockdown, BMI variations in parents were independent from those observed in their children, pointing to different outcomes in response to the same external, critical event. Thus, primary prevention measures aimed at maintaining a healthy lifestyle require different approaches according to age.
VNTR Polymorphism in Intron 4 of the eNOS Gene and the Risk of Gastrointestinal Bleeding: A Case-control Study
Authors: Forgerini Marcela , Urbano Gustavo , De Nadai Tales Rubens , Zanelli Cleslei Fernando , Valentini Sandro Roberto , Mastroianni Patrícia De Carvalho
Published: May 2022

Background and Aims: Considering the lack of knowledge regarding the influence of the variable number of repeats of 27 pb in intron 4 (4b/4a VNTR - rs61722009) of the endothelial nitric oxide synthase (eNOS) on the drug response, we assessed the influence of this polymorphism for the risk of upper gastrointestinal bleeding (UGIB).

Methods: A case-control study, including 200 cases and 706 controls, was conducted in a Brazilian hospital complex. Cases were participants with UGIB diagnosis. Controls were participants admitted to surgical procedures not related to gastrointestinal problems. The 4b/4a VNTR was determined through polymerase chain reaction followed by fragment analysis. Conditional logistic regression models were designed. The additive interaction between the presence of the 4b/4a VNTR variant and the use of low-dose aspirin (LDA) and nonsteroidal anti-inflammatory drugs (NSAIDs) was calculated by fitting the Cox regression model through the parameters of Synergism index (S) and Relative Excess Risk Due To Interaction (RERI).

Results: The presence of the 4b/4a VNTR variant did not increase the risk of UGIB: carriers of the 4a/4a genotype (OR=0.37, 95%CI: 0.09-1.45) and of the variant allele “4a” (OR=0.91, 95%CI: 0.55-1.51). The risk of UGIB in LDA users carriers of the wild genotype (OR=4.96, 95%CI: 2.04- 2.06) and the variant allele “4a” (OR=3.49, 95%CI: 1.18-10.38) is similar, as well as for NSAID users carriers of the wild genotype (OR=5.73, 95%CI: 2.61-12.60) and variant allele “4a” (OR=5.51, 95%CI: 1.42-15.82). No additive interaction was identified between the presence of the genetic variant and the use of LDA [RERI: -1.44 (95%CI: -6.02–3.14; S: 0.63 (95%CI: -1.97–1.15)] and NSAIDs [RERI: -0.13 (95%CI: -6.79–6.53; S: 0.97 (95%CI: -0.23–4.19)] on the UGIB risk.

Conclusion: Our data suggests that there is no increase in the magnitude of UGIB risk in LDA and NSAIDs users’ carrying the variant allele “4a”.
Burning Mouth Syndrome Etiology: A Narrative Review
Authors: Russo Michele , Crafa Pellegrino , Guglielmetti Simone , Franzoni Lorella , Fiore Walter , Di Mario Francesco
Published: May 2022

Burning mouth syndrome (BMS) is defined as “idiopathic orofacial pain with intraoral burning or dysesthesia recurring daily for more than 2 hours per day and more than 3 months, without any identifiable causative lesions, with or without somatosensory changes” in International Classification of Orofacial Pain, 2020. Worldwide prevalence of BMS was estimated to be 1.73% in population-based studies, while female and elderly are at higher risk of BMS. The aim of this narrative review is to clarify the main etiopathogenetic factors of BMS investigated so far in the scientific literature. There is growing evidence of an important role of peripheral neuropathology in BMS, supported by immunohistochemical studies which have demonstrated a significant loss of epithelial and subepithelial nerve fibers. Other possible etiopathogenetic factors emerging from literature are laryngopharyngeal reflux and hormonal and salivary changes related to aging and menopause. Finally, the role of the oral microbiota in BMS has not yet been thoroughly investigated. Further studies are necessary to investigate the probably multifactorial etiopathogenesis of primary BMS, a pathology which has a serious impact on the quality of life of our patients, a disease we find ourselves treating without the adequate therapy and the necessary knowledge.
To study the indications of cholecystectomy, types of surgery and complications of surgery in a tertiary care hospital in Nepal
Authors: Narayan Prasad Belbase , Sagar Khatiwada , Nishnata Koirala , Sushim Bhujel , Hari Prasad Upadhaya , Bikash Shah
Published: May 2022

Background: Cholelithiasis is a chronic recurrent disease of the hepatobiliary system and cholecystectomy is one of the commonly performed surgeries. This study intends to evaluate the demographic of patients with cholelithiasis, its various mode of presentation, surgical intervention, and its outcome. Methods: This was a quantitative retrospective cross-sectional study conducted in the College of Medical Sciences- a Superspeciality Tertiary Care Teaching Hospital in Bharatpur, Chitwan in central Nepal. All patients undergoing laparoscopic or open cholecystectomy in the department of GI and General Surgery at the College of Medical Sciences from 1st May 2017 to April 30, 2021were included in the study. Study tools were records of the patients retrieved from the medical record section. Results: A total of 355 patients data were analyzed. The mean age of the study samples was 46.43 +/- 16.47 years. Female predominance was seen at 76.18% with M: F ratio of 1:3.18. The most common presenting symptoms were pain abdomen (70.4%), bloating of the abdomen (63.9%), and fatty dyspepsia (46.8%). Acute cholecystitis was seen in 14.36%, biliary pancreatitis in 6.2%, and gallbladder perforation in 2.25% cases. Laparoscopic cholecystectomy was done in 269(83.94%), open cholecystectomy in 57(16.05%), and laparoscopic converted into open cholecystectomy 29 in (9.73%). Intra-operative complications like gallbladder perforation and controlled bleeding were seen in 10.14% and 4.23% of cases. Post-operative complications like bile leak and major bile duct injury were seen in 6.19% and 1.40% of cases. Regarding management of bile leak, conservative management was successfully done in 54.54% of cases while they were managed with ERCP in 27.27%, hepaticojejunostomy in 13.63%, and with T-tube repair in 4.5% cases. The overall mortality was 0.8%.
Glimepiride induced Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH): A case report
Authors: Afia Zainab Tanni , Md Farid Uddin , Shohael Mahmud Arafat , Shahjada Selim , Marufa Mustari , MSI Tipu Chowdhury
Published: May 2022

The Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) is an important cause of hyponatremia in hospitalized patients and can be caused by a variety of drugs. SIADH is a recognized side effect of 1st generation sulfonylurea (Chlorpropamide) due to its effect on vasopressin secretion. Here we described a 55-year-old woman with uncontrolled type 2 diabetes on glimepiride with SIADH presenting with anorexia, asthenia, and altered mental status. After the withdrawal of glimepiride, these symptoms were improved and sodium level returned to a normal value which demand monitoring of serum sodium level during treatment with glimepiride.
Serum trace element levels of liver cirrhosis and pancreatic cancer patients
Authors: H Sibel Karapinar , M Kürşat Türkdoğan , Fevzi Kiliçel
Published: May 2022

The incidence of liver cirrhosis and pancreatic cancer varies between countries and stands out as an important health problem worldwide. Liver cirrhosis is the most advanced stage of chronic liver disease and is a widespread result of chronic liver damage. The etiology of liver cirrhosis and pancreatic cancer, which are major causes of cancer fatalities in developed countries, is poorly understood. Many metabolic and physiological processes in the human body utilize trace elements. The creation and development of many diseases like cancer, cardiovascular, and diabetes mellitus occur with the disruption of trace element metabolism in the body as a result of improper nutrition, environmental, and occupational exposure, and impaired digestion and absorption. Methods and materials: In this study, copper (Cu), cadmium (Cd), iron (Fe), cobalt (Co), manganese (Mn), magnesium (Mg), nickel (Ni), zinc (Zn), and lead (Pb) concentrations were researched in the serum of liver cirrhosis and Pancreatic Cancer (PC) patients and healthy controls. Analysis of the elements was carried out by flame atomic absorption spectrophotometer. Results: Fe and Zn serum levels were considerably lower in individuals with liver cirrhosis and pancreatic cancer than in controls (p <0.001). Furthermore, mean serum levels of Cd and Mn in patients with liver cirrhosis and pancreatic Ca were considerably lower than in controls (p <0.01). In addition, when compared to pancreatic cancer, mean serum Cu and Ni levels in liver cirrhosis patients and controls were considerably lower (p <0.05). Mean serum levels of Pb in pancreatic Ca patients were significantly lower compared to liver cirrhosis patients and controls (p <0.05). When comparing all cancer patients to controls, mean serum Co and Mg levels were not substantially different. Conclusion: Deficiency in four trace elements (Cd, Mn, Fe, and Zn) was determined in patients with liver cirrhosis and pancreatic cancer. In addition, we have determined the deficiency of Cu and Ni trace elements (TEs) in pancreatic cancer patients. TE insufficiencies in cancer patients may be due to excessive consumption of foods and undernourishment. Epidemiological and physiological causes of trace element changes should be investigated further.
mRNA based vaccines as an alternative to conventional vaccine approaches
Authors: Zubda-tul Hoor , Muhammad Qadir
Published: May 2022

In recent years, vaccines based on mRNA are providing protection against infectious diseases and treatment for cancer. These vaccines offer many advantages as compared to traditional vaccines. They can be rapidly and easily manufactured at a low cost and are reliable for administration. These vaccines can generate both cell-mediated and humoral immunity. Their administration is still limited because of the risk of quick degradation and ineffectiveness after delivery. Technological advancements are recently being made to overcome these issues. This review summarizes current mRNA vaccine development, safety concerns, advances in delivery systems, clinical trials, and various therapeutic applications of mRNA vaccines.
[RETRACTED] Limitless Glucose 1 (Scam Pills Or Legit) Full Detailed Review! v1
Authors: Glucose Limitless
Published: May 2022

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[RETRACTED] Keto Advanced 1500 Review- Ingredients and Benefits, Price, Official Website -2022 v1
Authors: not provided bawi.jaice
Published: May 2022

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Different elements can cause weight gain, including an absence of satisfactory active work to consume calories. An individual ought to spend no less than 150 minutes out of every week on extraordinary activity and no less than two meetings devoted to expanding body strength. In any case, an enormous section of the populace has a stationary way of life and a great many people don't focus on actual work. Diet is a central point of contention, too. The majority of the populace's eating regimen comprises of a wealth of carbs and deficient solid fats and proteins. Accordingly, this diet makes fat stores around the body, making individuals become overweight.
[RETRACTED] MaasaLong Reviews - Is MaasaLong Pills Safe? v1
Authors: Reviews Maasalong
Published: May 2022

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[RETRACTED] GenXZ Keto Gummies *Read 8 Facts*100% Clinically Certified Ingredients! v1
Authors: Keto Gummies GenXZ
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Published: May 2022

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[RETRACTED] Lifestyle Keto Gummies: Reviews, exposed 2022, 100% natural diet, does it work and is it trusted? v1
Authors: Keto Lifestyle
Published: May 2022

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[RETRACTED] Limitless Glucose 1 Review : Blood Sugar (Glucose) Level Lower Than Standard Range? (What They Won’t Share) v1
Authors: Glucose Limitless
Published: May 2022

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[RETRACTED] Epik Health Keto Gummies Reviews! v1
Authors: Health Keto Gummies Epik
Published: May 2022

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Effect of Soil Physical Properties on Surface Runoff in Lukulo Upstream Watershed
Authors: Raharjo Puguh Dwi , Puswanto Eko , Winduhutomo Sueno , Al'Afif Mohammad , Wibowo Dimas Aryo , Yudaputra Angga
Published: May 2022

Lukulo upstream watershed is one of the watersheds in Central Java Province, which passes through 3 districts; Kebumen, Wonosobo, and Banjarnegara. Lukulo upstream watershed has eight sub-watersheds located in areas with diverse topography and lithology. The diversity of topography and lithology affects the characteristics of the area, as does the physical condition of the soil. The physical condition of this soil affects the runoff. Soil’s physical properties control rainwater to run off and have important effects on runoff behavior in watersheds. This study aims to determine the physical properties of the soil against runoff in each sub-watershed and each part of the watershed. The method used uses a laboratory, studio, and field approach.  The results obtained show that the physical properties of the soil in the Lukulo upstream watershed affect the amount of runoff resistance in the upstream area; in the downstream area the runoff is relatively good. The study also shows two different results. In the Loning watershed, the velocity of downstream runoff is higher than the upstream, while in the Lokidang and Medana watershed, level of surface water flow is lower in the downstream area.
Assessment of Ecosystem Services and Environmental Degradation by Using Landscape Approach in The Riparian Area of Lake Rawapening
Authors: Waskita Taufik Budi , Jatti Agasi Purnama , Putra Boma Karunia Dwi , Satya Fiqh Arya , Rifqy Muhammad , Pramanto Tegar Dwi , Setiawan Muhammad Anggri
Published: May 2022

Lake Rawapening is a unique landscape that naturally provides provisioning, regulatory, cultural, and supporting ecosystem services. On the other side, Rawapening Lake is an open access area that is subject to be vulnerable to any economic activities that lead to environmental degradation. This study aims to identify the spatial distribution of ecosystem services provided in part of the riparian area of Rawapening Lake using a geomorphological approach with detailed scale mapping and identify environmental degradation that occurred in the area in two time periods, 2016 and 2020. Data analysis was carried out using Scoring and Pairwise Comparison techniques to produce Ecosystem Services Index and Ecosystem Services Composite Index values presented in a Spatio-temporal manner. The results of the analysis using the Geographic Information System (GIS) show that the dynamics of the landscape that occurred in 2016 and 2020 caused changes in the provision of ecosystem services in terms of the area. In these two periods, the Landscape Lake Rawapening had the highest Ecosystem Services Composite Index(IKJE). However, the threat of environmental degradation caused by anthropogenic activities is always lurking and can lead to a decrease in the quality and quantity of the provision of ecosystem services from the landscape. Therefore, it is necessary to conduct a study on the physical and socio-economic characteristics of the study area to assist policymakers in formulating the determination of lake riparian area and zoning of related resource use.
The Role of Tradisional Belief and Local Wisdom in Forest Conservation
Authors: Mulyadi Asep , Dede Moh. , Widiawaty Millary Agung
Published: May 2022

Deforestation has become a global issue, primary forests have been converted to plantations, agricultural land, and built-up area. Although many environmental regulations have been enacted since the emergence of the sustainable development concept, in reality, they are not effective when compared to forest management by indigenous peoples. This article intends to reveal the role of traditional beliefs and local wisdom in forest conservation. We selected five indigenous communities as representatives of beliefs and forest conservation efforts in Indonesia ie. Nagari Sungai Buluh, Mollo, Kampung Naga, Manggarai, and Dayak Kanayatn. This research uses qualitative data that is analyzed by descriptive approach, it can explain in detail the forest management by indigenous peoples. Traditional belief systems and conservation have proven to maintain the forests, also ensure the availability of natural resources and ecosystem services for humans in the surrounding. The indigenous peoples consider the forest to be a clean and sacred place, it can only be accessed or used at certain times. The forest zoning by indigenous peoples guarantees its sustainability and is evidence of the application of ecocentrism, humans are part of nature and are obliged to protect the resources that have been mandated by God.
Scientific Writing Skills of Students in Tourism Geography Course of the Geography Education Program Universitas PGRI Kanjuruhan
Authors: Jayanti Mustika Arif , Malik Jamil Ahmad Maulana
Published: May 2022

The skill of writing scientific papers in this research is prioritized in writing papers. Considerations in choosing a paper as a scientific paper to be written by students include at the beginning of the semester where each course assignment always makes a paper. The purpose of this study was to describe variables based on indicators and descriptors of the research variables. The type of this research is quantitative descriptive. Based on the data analysis that has been carried out on the ability to develop the content of scientific papers, it can be seen that the average score obtained is 84.85 which shows that the ability of students in developing the content of scientific papers has a fairly good value. This shows that the aspect of developing content in the writings that have been made by students has quite an interesting title. The content in the paper reflects the problem according to the title, the existing discussion is also related to the topic of the problem and the conclusions that can be said to be quite detailed for the standard of students. The individual completeness scores of students who can be declared complete are 18 students by 90%, because they have been able to achieve a minimum mastery level of students more than or equal to 78, while a number of 2 students by 10% have not been able to achieve learning mastery because their scores are still below 78.
COVER GEA VOL 22, NUMBER 1 APRIL 2022
Authors: Gea Gea
Published: May 2022

COVER
Weasel in the Traditional Folk Ideas of Ukrainians
Authors:   Ivan Franko National University of Lviv, Halaichuk Volodymyr
Published: May 2022

The article presents a comprehensive description of the folk ideas of Ukrainians about the weasel and clarifies their etiology. On the basis of already published ethno­graphic sources and field materials of the author considered the idea of the relation of a weasel to cattle (the choice of a color of cattle depending on the color of a weasel which is found on a household; braiding the mane, harm to cattle from a weasel), about the toxicity of weasel, about the prohibition to offend her, about the connection between the weasel and the day of St. Vlasiy. It turned out that Ukrainians believe that the best cattle for the farm are those whose color corresponds to the color of a weasel. It is also believed that each cow has its weasel. Despite the assistance, the weasel allegedly harms cattle. It was believed that she sucked the blood of a horse or cow, drove the horse or cow to sweat, sucked milk, and that her bite could swell the udder of a cow; if a weasel runs under a cow, that cow gets sick and starts milking with blood. If the weasel braided the horse’s mane, it could not be untied, otherwise the animal will get sick. According to popular belief, the weasel could not be offended, because it would harm cattle or even people. In addition, people did not insult the weasel because they understood the benefits of them for the economy (destroying mice). In part, the ban on offending the weasel is due to the special attitude towards «non-domestic» animals that have found themselves in the space of a house or living space. Sometimes the weasel is directly identified with the hobgoblin. They have much in common in functions aimed at livestock. The status of the weasel in the Ukrainian mythological system varies from a zoomorphic variant of a hobgoblin to an animal with certain mythological features. In many ways, the weasel is close to the «domestic snake». Both live in an underground chthonic world in the vicinity of the farm, which corresponds to the location of the souls of «their» dead. Weasel is considered poisonous. She allegedly can bite for the damage or for violating the ban on work on St. Vlasiy’s day. In general, most popular beliefs of Ukrainians allow us to consider the weasel a kind of so-called «house spirits».
The Beginning of I. M. Yeremeiev’s Scientific Activity and his First Research in the Field of Agronomy (1909–1912)
Authors:   State higher educational establishment «Pereiaslav-Khmelnytskyi State Hryhorii Skovoroda Pedagogical University», Safarians Halyna
Published: May 2022

The article is devoted to the exploration of the first period of Ivan Maksymovych Yeremeiev’s scientific activity during his studies in France. I. M. Yeremeiev began his scientific path in France, where he obtained the qualification of an agriscientist engineer at the Agricultural University in Nancy. This allowed him to continue his studies and engage in practical experiments at the Botanical Garden of Sorbonne, where he was able to acquire the latest views and methods of agronomy from French scientists. Here the future breeder first gets acquainted with the practice of breeding, working for Vilmoren company. During this period, the first scientific articles of the young scientist on the subject of horticulture, vegetable growing and phytopathology were published in specialized journals of the Russian Empire. These works provide an opportunity to analyze the formation of I. M. Yeremeiev as a scientist and to outline the scope of his specialization – the problem of plant pathology. Research characterizes him as a scientist who has an innovative view of agronomic science and original ideas for its practical implementation. The article analyzes the first substantial paper of the scientist «Diseases of fruit trees and their control», which describes in detail his research in the field of phytopathology. The paper was written on the basis of theoretical knowledge acquired by I. М. Yeremeiev during his studies. The results obtained from his own practical experiments and observations, which he performed while working at Vilmoren company, served as an important source material for the paper. The young scientist is an expert in the study of fruit trees fungal diseases and means of combating them. His paper is an important source for further research on plant disease. Thus, we conclude that in the period from 1909 to 1912 I. М. Yeremeiev was formed as a scientist, practitioner and phytopathologist. Knowledge in this area allowed to perform further work on the selection of agricultural crops.
An impact of the novel coronavirus infection (COVID-19) on human reproductive function
Authors: Garibidi E. V. , Shatunova E. P. , Fedorina T. A. , Garibidi D. E.
Published: May 2022

The latest data on the impact of the novel coronavirus infection (COVID-19) on female and male reproductive health are reviewed. Pathological changes in organs and tissues of human reproduction system after COVID-19 as well as  recommendations for rehabilitation of couples planning pregnancy after COVID-19 are discussed. Moreover, issues of the reproductive health resulting from altered psychologic status in women after COVID-19 were highlighted as well.
Quality of life and psychoemotional status in patients with external genital endometriosis
Authors: Begovich E. , Solopova A. G. , Khlopkova S. V. , Son E. A. , Idrisova L. E.
Published: May 2022

Introduction. Chronic pain syndrome with external genital endometriosis (EGE) causes profound psychoemotional changes, anxiety disorders, decreased physical and social activity, general well-being and mood, sexual dysfunction, and as a consequence, deteriorated quality of patients' life.

Aim: to study an influence of psychoemotional disorders on the quality of life of women with painful and painless forms of EGE.

Material and Methods. There were enrolled 160 patients (110 women with painful and 50 with painless forms of EGE) of reproductive age with laparoscopically and morphologically verified diagnosis, according to the Revised American Fertility Society score (R-AFS) classification. Pain syndrome and psychoemotional status were assessed using various quality of life assessment questionnaires: Visual Analog Scale (VAS), Endometriosis Health Profile-30 (EHP-30), Hospital Anxiety and Depression Scale (HADS). After surgical treatment, 8 patients refused to participate in the work (6 with painful form of EGE and 2 with painless form). Thus, 152 women passed all stages of the study. The patients were divided into 4 groups depending on the presence and/or absence of pain syndrome and tactics of the rehabilitation period ("active" or "passive"): group IA consisted of 49 (47.1 %) women with pain syndrome and "active" rehabilitation; group IБ – 55 (52.9 %) women with pain syndrome and "passive" rehabilitation tactics; group IIA – 23 (47.9 %) patients without pain syndrome and with "active" rehabilitation; group IIБ – 25 (52.1 %) patients without pain syndrome and with "passive" rehabilitation tactics.

Results. It was found that painful vs. painless form of EGE differs by a more severe course of the disease and markedly decreased quality of life. In a comparative analysis of the four groups it was noted that women with "active" tactics of rehabilitation measures (IA and IIA) had a decrease in pain syndrome, improved emotional, social and sexual activity, decreased depression and anxiety scores as compared to the patients (IБ and IIБ) who underwent a set of rehabilitation measures within the National clinical guidelines.

Conclusion. Timely diagnostics and correction of psychoemotional disorders will allow to develop a differentiated approach to provide specialized medical and psychological care and improve the quality of life of patients with EGE.
Anticoagulants: dose control methods and inhibitors
Authors: Bitsadze V. O. , Slukhanchuk E. V. , Khizroeva J. Kh. , Tretyakova M. V. , Tsibizova V. I. , Gashimova N. R. , Nakaidze I. A. , Elalamy I. , Gris J.-C. , Makatsariya A. D.
Published: May 2022

These days, anticoagulants are in great demand. They are used as a prophylaxis for thromboembolic complications in various diseases and conditions in general therapeutic practice, cardiology, neurology, as well as obstetrics to manage high-risk pregnancies. The relevance of anticoagulants competent use has come to the fore in connection with the emergence of a new disease – COVID-19 and its serious complications such as developing thrombotic storm, in which the timely applied anticoagulant therapy is the key to the success of therapy. The risk of bleeding should be considered when using any anticoagulant. Age, impaired renal function and concomitant use of antiplatelet agents are common risk factors for bleeding. Moreover, only vitamin K antagonists and heparin have specific antidotes – vitamin K and protamine, respectively. Inhibitors of other anticoagulants are universal presented as inactivated or activated prothrombin complex concentrate and recombinant factor VIIa. Hemodialysis effectively reduces dabigatran concentration, activated charcoal is effective in the case of recent oral administration of lipophilic drugs. Research on new antidotes of currently available anticoagulants is under way, similar to testing of new types of anticoagulants that are sufficiently effective in preventing and treating thromboembolic complications with minimal risk of hemorrhagic. The main contraindication to anticoagulants use is the doctor's ignorance of the mechanisms of drug action and opportunities for suppressing its effect.
Prevention of recurrent fetal growth retardation in patients with circulating antiphospholipid antibodies and genetic thrombophilia
Authors: Orudzhova E. A. , Bitsadze V. O. , Tretyakova M. V. , Doronicheva D. A. , Yakubova F.
Published: May 2022

Aim: to evaluate the effectiveness of using low molecular weight heparin (LMWH) and low-dose acetylsalicylic acid (ASA) in preventing recurrence of early and late fetal growth retardation (FGR) in patients with antiphospholipid syndrome (APS) and/or genetic thrombophilia.

Materials and Methods. A prospective randomized controlled study was conducted by examining 32 patients aged 23 to 43 years with a history of early and late II and III FGR as well as thrombophilia. Prevention protocol using LMWH and ASA was carried out from the pregravid period or early pregnancy. The control group included 35 women with uncomplicated pregnancy. Antiphospholipid antibodies (APA) were measured according to the Sydney antiphospholipid syndrome (APS) criteria by using enzyme immunoassay (ELISA): cardiolipin, β2-glycoprotein 1 and additionally antibodies to annexin V, prothrombin, etc. (IgG/IgM isotypes); lupus anticoagulant – by a three-stage method with Russell's viper venom; antithrombin III and protein C levels – by chromogenic method; prothrombin gene polymorphisms G20210A as well as factor V Leiden polymorphism – by chain reaction; homocysteine – by ELISA.

Results. It was found that prevention protocol was effective in 78.1 % cases. FGR re-developed in 7 (21.9 %) pregnant women: in 2 (6.3 %) at 20 and 22 weeks, in 3 (9.4 %) at 30–32 weeks, in 2 (6.3 %) after 34 weeks of pregnancy. All these patients were found to have APA exceeding 40 U/ml with low dynamics of decline, 3 (9.4 %) were older than 35 years, 2 (6.3 %) had chronic kidney pathology and 1 (3.1 %) had a hypertension in the anamnesis.

Conclusion. The use of LMWH and low-dose ASA starting from the pre-pregnancy period and early pregnancy as a part of complex therapy allows to effectively prevent re-development of FGR in patients with thrombophilia. In case of high APA titers, the use of LMWH and low-dose ASA may be ineffective, and alternative treatment methods in addition to anticoagulant therapy should be used to improve obstetric results.