bluuebunny/crossref_metadata_2025 huggingface dataset:
Energy consumption modeling and analysis for short-reach optical transmissions using irregular LDPC codes
Authors: Zheng Ziyuan , Yang Chuanchuan , Yang Chun , Wang Ziyu
Published: October 2022

As the transmission rate of data center (DC) related short-reach optical transmissions quickly increases to keep up with internet services’ data demand pace, advanced FEC technology starts to establish its key role in short reach optical transmission systems. Coding strategy using Quasi-Cyclic LDPC (QC-LDPC) codes with hard-decision (HD) decoders stands out due to its excellent error correction ability and simple hardware implementation. Meanwhile, with the introduction of green communication concept and increasingly extensive applications of DC, energy consumption of short-reach links has become an urgent problem to be studied. Based on tanner-graph, energy consumption models of regular LDPC codes’ HD decoding circuits over AWGN channel have been proposed. In this work, for the first time, we introduce energy consumption of optical transmitters and characteristics of short reach optical channels into energy consumption modeling. Besides, probability distributions of flipping operation as well as bit errors during irregular QC-LDPC codes’ HD decoding iterations are analytically derived using density evolution algorithm. Based on our proposed model and post-layout circuit simulation, systems’ total power when using four QC-LDPC codes in IEEE and 3GPP with Gallager A/B decoders together with the case of using no FEC are analyzed in two typical scenarios. Numerical results show that, in short range scenario with slight bandwidth limit, uncoded strategy is much more energy-saving than all adopted LDPC-coded strategies in 50Gbaud OOK and 25Gbaud PAM4 transmissions. While in severely band-limited case when FEC is necessary, a tradeoff between energy consumption of transmitters and decoders occurs in 70Gbaud OOK and 35Gbaud PAM4 transmissions. Besides, LDPC codes with longer length at similar rate are proved to consume less power for their better error correction ability. And in long range scenario, power differences among coding strategies grow significantly when pre-bit error rate (BER) approaches their error correction threshold, reflecting the great influence of error correction threshold on the energy consumption of LDPC decoders. Among all adopted coding strategies, a (19200, 15872) LDPC code with Gallager B decoder consumes minimum power in both two scenarios. However, it is also found that decoding algorithm minimizing the total power differs at different pre-BER if we concentrate on decoding algorithm, justifying the significance of our modeling in minimizing system energy consumption.
Single-shot measurement of the near-field and focal spot profiles of a 351 nm laser beam for SGII-upgraded facility with multiple-focal-plane constraint coherent modulation imaging
Authors: He Xiaoliang , Pan Xingchen , Tao Hua , Liu Cheng , Zhu Jianqiang
Published: October 2022

Inertial confinement fusion (ICF) places an urgent demand for precise measurement of 351 nm (3ω) laser beam parameters when performing physical experiments on high-power laser facilities. The near-field and focal spot distributions are the utmost important parameters to characterize the quality of the laser beam. Coherent modulation imaging (CMI) is a promising technique for online laser beam measurement, however, it fails to reconstruct the near-field and focal spot profiles when it is used to measure the beam quality of a 351 nm laser beam for SGII-upgrade facility. To solve this problem, a novel CMI reconstruction algorithm is proposed in this work, and the performance of the algorithm in 3ω laser beam measurement can be obviously improved. By adopting multiple-virtual-focal-plane constraint in the proposed algorithm, the near-field and focal spot profiles of the 3ω laser beam can be successfully reconstructed. Experiments have been conducted on SGII-upgrade facility to verify the feasibility of the proposed method.
Efficient frequency conversion and the crossing-pump effect of stimulated Raman scattering in an aqueous sodium sulfate solution
Authors: Xu Yang , Dou Zhenguo , Xing Lu , Li Zhanlong , Men Zhiwei , Sun Chenglin , Wang Shenghan
Published: October 2022

The cascaded stimulated Raman scattering (SRS) of an aqueous sodium sulfate solution was investigated as well as the generation of the crossing-pump effect. With the introduction of dual sample cells, the first-order Stokes of the O-H stretching vibrational mode was able to act as the pump light to excite the Stokes of the S-O stretching vibrational mode, and a new Raman peak was obtained at 4423 cm-1. The dual sample cell device not only lowered the SRS threshold, but also enhanced the four-wave mixing (FWM) process. Compared to the input laser of 7 ns/pulse, the first-order Stokes of O-H was compressed to a pulse width of 413 ps after passing through the dual sample cells. The SRS of aqueous sodium sulfate solution covered an ultrabroad wavelength ranging from 441 nm to 720 nm (a Raman shift ranging from -3859 cm-1 to 4923 cm-1). The cone-shaped launch ring of the FWM process was also recorded. This work provides a reference for the establishment of laser frequency conversion devices using an aqueous sodium sulfate solution as the Raman medium.
Piezoelectric-based optical modulator for miniaturized wireless medical implants
Authors: Edmunds Jordan L. , Sonmezoglu Soner , Maharbiz Michel M.
Published: October 2022

Optical links for medical implants have recently been explored as an attractive option primarily because it provides a route to ultrasmall wireless implant systems. Existing devices for optical communication either are not CMOS compatible, require large bias voltages to operate, or consume substantial amounts of power. Here, we present a high-Q CMOS-compatible electro-optic modulator that enables establishing an optical data uplink to implants. The modulator acts as a pF-scale capacitor, requires no bias voltage, and operates at CMOS voltages of down to 0.5V. We believe this technology would provide a path towards the realization of millimeter (mm)- and sub-mm scale wireless implants for use in bio-sensing applications.
Threshold fluence and incubation during multi-pulse ultrafast laser ablation of quartz
Authors: De Palo Raffaele , Volpe Annalisa , Gaudiuso Caterina , Patimisco Pietro , Spagnolo Vincenzo , Ancona Antonio
Published: October 2022

In this work, the incubation effect on the laser ablation threshold of quartz, after multi-shot irradiation with femtosecond pulses at 1030-nm-wavelength with different repetition rates, was investigated. A strong decrease of the multi-pulse ablation threshold with the number of pulses N was found due to incubation. Moreover, the influence of the repetition rate was negligible in the investigated frequency range which went from 0.06 to 200 kHz. A saturation of the threshold fluence value was observed at number of pulses N > 100 which has been found to be well fitted by an exponential incubation model. Using such model, we estimated the single-pulse ablation threshold value and the incubation coefficient for quartz, which were found equal to Fth,1 = 6.23 ± 0.23 J/cm2 and k = 0.058 ± 0.004.
High-performance one-dimensional MOSFET array photodetectors in the 0.8-µm standard CMOS process
Authors: Liu Yaxuan , Sun Jingye , Tong Ling , Li Yuning , Deng Tao
Published: October 2022

This paper reports a series of novel photodetectors based on one-dimensional array of metal-oxide-semiconductor field-effect transistors (MOSFETs), which were fabricated using the standard 0.8-µm complementary metal oxide semiconductor (CMOS) process. Normally, the metal fingers of MOSFET must be manufactured above active region in standard CMOS process, causing MOSFET insensitive to light. The proposed photodetectors use the metal fingers of MOSFETs in a one-dimensional array to form periodical slit structures, which make the transmittance of incident light higher, due to the surface plasmons (SPs) resonance effect. The number of parallel MOSFETs in one-dimensional array is 3, 5, 7, 9 and 11. The experimental results show that all responsivities (Rv) are greater than 103 A/W within visible and near-infrared spectra under room temperature and a maximum value of 1.40 × 105 A/W is achieved, which is at least one order of magnitude larger than those of published photodetectors. Furthermore, a minimum noise equivalent power (NEP) of 5.86 fW/Hz0.5 at 30 Hz and a maximum detectivity (D*) of 2.21 × 1013 Jones are obtained. The photodetectors still have good signal-to-noise ratio when the bandwidth is 1 GHz. At the same time, the optical scanning imaging was completed by utilizing the photodetectors. This combination of high Rv, excellent NEP, high speed and broad spectrum range photodetectors will be widely used in imaging systems.
Optical trapping of multiple particles based on a rotationally-symmetric power-exponent-phase vortex beam
Authors: Wu Ziheng , Zhao Jiang , Dou Jiantai , Liu Jun , Jing Qingli , Li Bo , Hu Youyou
Published: October 2022

In this paper, the optical trapping of multiple particles based on a rotationally-symmetric power-exponent-phase vortex beam (RSPEPVB) was introduced and demonstrated. Based on the theories of tight focusing and optical force, the optical force model of RSPEPVB was established to analyze the optical trapping force of tightly focused RSPEPVB. Then, an experimental setup of optical tweezer, by utilizing the RSPEPVB, was built to demonstrate that the optical tweezer of RSPEPVBs can achieve the optical trapping of multiple particles, and the number of captured particles is equal to the topological charge l of RSPEPVB, which shows that the RSPEPVBs can achieve multi-particles trapping with controllable number. Moreover, compared to vortex beam, the captured particles by RSPEPVB will not rotate around the circular light intensity distribution. The results will provide a new option for optical trapping of multiple particles in biomedicine, laser cooling and so on.
Biphoton engineering using modal spatial overlap on-chip
Authors: Ding Xiangyan , Ma Jing , Tan Liying , Helmy Amr S. , Kang Dongpeng
Published: October 2022

Photon pairs generated by spontaneous parametric downconversion are essential for optical quantum information processing, in which the quality of biphoton states is crucial for the performance. To engineer the biphoton wave function (BWF) on-chip, the pump envelope function and the phase matching function are commonly adjusted, while the modal field overlap has been considered as a constant in the frequency range of interest. In this work, by using modal coupling in a system of coupled waveguides, we explore the modal field overlap as a new degree of freedom for biphoton engineering. We provide design examples for on-chip generations of polarization entangled photons and heralded single photons. This strategy can be applied to waveguides of different materials and structures, offering new possibilities for photonic quantum state engineering.
Experimental demonstration of tomography-based quantum key distribution
Authors: Wei Min , Zhang Chun-Hui , Li Jian , Zhu Jia-Li , Wang Qin
Published: October 2022

Tomography is a very beneficial and fundamental technique in the fields of quantum information and quantum optics, which can be applied to infer information about quantum states or quantum processes. In quantum key distribution (QKD), tomography can be proposed to improve the secure key rate by taking full advantage of data from both matched and mismatched measurement outcomes to characterize quantum channels accurately. However, to date, no experimental work has been conducted on it. In this work, we study tomography-based QKD (TB-QKD), and for the first time, to the best of our knowledge, carry out proof-of-principle experimental demonstrations by implementing Sagnac interferometers to simulate different transmission channels. Furthermore, we compare it with reference-frame-independent QKD (RFI-QKD) and demonstrate that TB-QKD can significantly outperform RFI-QKD in certain channels, e.g., amplitude damping channel or probabilistic rotation channel.
Vigilance, arousal, and acetylcholine: Optimal control of attention in a simple detection task
Authors: Chebolu Sahiti , Dayan Peter , Lloyd Kevin
Published: October 2022

Paying attention to particular aspects of the world or being more vigilant in general can be interpreted as forms of ‘internal’ action. Such arousal-related choices come with the benefit of increasing the quality and situational appropriateness of information acquisition and processing, but incur potentially expensive energetic and opportunity costs. One implementational route for these choices is widespread ascending neuromodulation, including by acetylcholine (ACh). The key computational question that elective attention poses for sensory processing is when it is worthwhile paying these costs, and this includes consideration of whether sufficient information has yet been collected to justify the higher signal-to-noise ratio afforded by greater attention and, particularly if a change in attentional state is more expensive than its maintenance, when states of heightened attention ought to persist. We offer a partially observable Markov decision-process treatment of optional attention in a detection task, and use it to provide a qualitative model of the results of studies using modern techniques to measure and manipulate ACh in rodents performing a similar task.
DMFpred: Predicting protein disorder molecular functions based on protein cubic language model
Authors: Pang Yihe , Liu Bin
Published: October 2022

Intrinsically disordered proteins and regions (IDP/IDRs) are widespread in living organisms and perform various essential molecular functions. These functions are summarized as six general categories, including entropic chain, assembler, scavenger, effector, display site, and chaperone. The alteration of IDP functions is responsible for many human diseases. Therefore, identifying the function of disordered proteins is helpful for the studies of drug target discovery and rational drug design. Experimental identification of the molecular functions of IDP in the wet lab is an expensive and laborious procedure that is not applicable on a large scale. Some computational methods have been proposed and mainly focus on predicting the entropic chain function of IDRs, while the computational predictive methods for the remaining five important categories of disordered molecular functions are desired. Motivated by the growing numbers of experimental annotated functional sequences and the need to expand the coverage of disordered protein function predictors, we proposed DMFpred for disordered molecular functions prediction, covering disordered assembler, scavenger, effector, display site and chaperone. DMFpred employs the Protein Cubic Language Model (PCLM), which incorporates three protein language models for characterizing sequences, structural and functional features of proteins, and attention-based alignment for understanding the relationship among three captured features and generating a joint representation of proteins. The PCLM was pre-trained with large-scaled IDR sequences and fine-tuned with functional annotation sequences for molecular function prediction. The predictive performance evaluation on five categories of functional and multi-functional residues suggested that DMFpred provides high-quality predictions. The web-server of DMFpred can be freely accessed fromhttp://bliulab.net/DMFpred/.
A cryptic transcription factor regulates Caulobacter adhesin development
Authors: McLaughlin Maeve , Hershey David M. , Reyes Ruiz Leila M. , Fiebig Aretha , Crosson Sean
Published: October 2022

Alphaproteobacteria commonly produce an adhesin that is anchored to the exterior of the envelope at one cell pole. In Caulobacter crescentus this adhesin, known as the holdfast, facilitates attachment to solid surfaces and cell partitioning to air-liquid interfaces. An ensemble of two-component signal transduction (TCS) proteins controls C. crescentus holdfast biogenesis by indirectly regulating expression of HfiA, a potent inhibitor of holdfast synthesis. We performed a genetic selection to discover direct hfiA regulators that function downstream of the adhesion TCS system and identified rtrC, a hypothetical gene. rtrC transcription is directly activated by the adhesion TCS regulator, SpdR. Though its primary structure bears no resemblance to any defined protein family, RtrC binds and regulates dozens of sites on the C. crescentus chromosome via a pseudo-palindromic sequence. Among these binding sites is the hfiA promoter, where RtrC functions to directly repress transcription and thereby activate holdfast development. Either RtrC or SpdR can directly activate transcription of a second hfiA repressor, rtrB. Thus, environmental regulation of hfiA transcription by the adhesion TCS system is subject to control by an OR-gated type I coherent feedforward loop; these regulatory motifs are known to buffer gene expression against fluctuations in regulating signals. We have further assessed the functional role of rtrC in holdfast-dependent processes, including surface adherence to a cellulosic substrate and formation of pellicle biofilms at air-liquid interfaces. Strains harboring insertional mutations in rtrC have a diminished adhesion profile in a competitive cheesecloth binding assay and a reduced capacity to colonize pellicle biofilms in select media conditions. Our results add to an emerging understanding of the regulatory topology and molecular components of a complex bacterial cell adhesion control system.
Prophylactic low-dose, bi-weekly benznidazole treatment fails to prevent Trypanosoma cruzi infection in dogs under intense transmission pressure
Authors: Bustamante Juan M. , Padilla Angel M. , White Brooke , Auckland Lisa D. , Busselman Rachel E. , Collins Stephanie , Malcolm Elizabeth L. , Wilson Briana F. , Saunders Ashley B. , Hamer Sarah A. , Tarleton Rick L.
Published: October 2022

Trypanosoma cruzi naturally infects a wide variety of wild and domesticated mammals, in addition to humans. Depending on the infection dose and other factors, the acute infection can be life-threatening, and in all cases, the risk of chagasic heart disease is high in persistently infected hosts. Domestic, working, and semi-feral dogs in the Americas are at significant risk of T. cruzi infection and in certain settings in the southern United States, the risk of new infections can exceed 30% per year, even with the use of vector control protocols. In this study, we explored whether intermittent low-dose treatment with the trypanocidal compound benznidazole (BNZ) during the transmission season, could alter the number of new infections in dogs in an area of known, intense transmission pressure. Preliminary studies in mice suggested that twice-weekly administration of BNZ could prevent or truncate infections when parasites were delivered at the mid-point between BNZ doses. Pre-transmission season screening of 126 dogs identified 53 dogs (42.1%) as T. cruzi infection positive, based upon blood PCR and Luminex-based serology. Serial monitoring of the 67 uninfected dogs during the high transmission season (May to October) revealed 15 (22.4%) new infections, 6 in the untreated control group and 9 in the group receiving BNZ prophylaxis, indicating no impact of this prophylaxis regimen on the incidence of new infections. Although these studies suggest that rigorously timed and more potent dosing regimen may be needed to achieve an immediate benefit of prophylaxis, additional studies would be needed to determine if drug prophylaxis reduced disease severity despite this failure to prevent new infections.
Characterization of a novel pyruvate kinase from Trichinella spiralis and its participation in sugar metabolism, larval molting and development
Authors: Yue Wen Wen , Yan Shu Wei , Zhang Ru , Cheng Yong Kang , Liu Ruo Dan , Long Shao Rong , Zhang Xi , Wang Zhong Quan , Cui Jing
Published: October 2022

Background

Pyruvate kinase widely exists in many parasites and plays an important role in the energy production for the parasites. Pyruvate kinase might be a potential drug target for killing the parasites. The aim of the present study was to evaluate the biological characteristics and roles of T. spiralis pyruvate kinase M (TsPKM) in sugar metabolism, larval molting and development of T. spiralis.

Methodology/Principal findings

TsPKM has two functional domains of pyruvate kinase and the tertiary structure of TsPKM is tetramer which has the enzyme active site constituted by 8 amino-acid residues (Arg71, Asn73, Asp110, Phe241, Lys267, Glu269, Asp293 and Thr325). Recombinant TsPKM (rTsPKM) was expressed and purified. The rTsPKM had good immunogenicity. RT-PCR and Western blot showed that TsPKM was transcribed and expressed at various developmental stages in T. spiralis lifecycle. Immunofluorescence test showed that TsPKM was principally located in the cuticle, muscle, stichosome, intestine and the intrauterine embryos of female adults. rTsPKM catalyzed the reaction of phosphoenolpyruvate (PEP) and adenosine diphosphate (ADP) to produce pyruvic acid and adenosine triphosphate (ATP). TsPKM played an important role in the metabolism and energy production of T. spiralis. After silencing of TsPKM gene by specific dsRNA-TsPKM2, protein expression and enzyme activity of TsPKM decreased by 50.91 and 26.06%, respectively. After treatment with RNAi, natural TsPKM enzyme activity, larval molting, sugar metabolism, growth and development of T. spiralis were significantly reduced.

Conclusions

TsPKM participates in the larval molting, sugar metabolism, growth and development of T. spiralis and it might be a candidate target of therapeutic drug of trichinellosis.
The number of cases, mortality and treatments of viral hemorrhagic fevers: A systematic review
Authors: Belhadi Drifa , El Baied Majda , Mulier Guillaume , Malvy Denis , Mentré France , Laouénan Cédric
Published: October 2022

Background

Viral hemorrhagic fevers (VHFs) are a group of diseases, which can be endemo-epidemic in some areas of the world. Most of them are characterized by outbreaks, which occur irregularly and are hard to predict. Innovative medical countermeasures are to be evaluated but due to the field specificities of emerging VHF, challenges arise when implementing clinical studies. To assess the state of the art around VHFs, we conducted a systematic review for all reports and clinical studies that included specific results on number of cases, mortality and treatment of VHFs.

Methods

The search was conducted in January 2020 based on PRISMA guidelines (PROSPERO CRD42020167306). We searched reports on the WHO and CDC websites, and publications in three international databases (MEDLINE, Embase and CENTRAL). Following the study selection process, qualitative and quantitative data were extracted from each included study. A narrative synthesis approach by each VHF was used. Descriptive statistics were conducted including world maps of cases number and case fatality rates (CFR); summary tables by VHF, country, time period and treatment studies.

Results

We identified 141 WHO/CDC reports and 126 articles meeting the inclusion criteria. Most of the studies were published after 2010 (n = 97 for WHO/CDC reports and n = 93 for publications) and reported number of cases and/or CFRs (n = 141 WHO/CDC reports and n = 88 publications). Results varied greatly depending on the outbreak or cluster and across countries within each VHF. A total of 90 studies focused on Ebola virus disease (EVD). EVD outbreaks were reported in Africa, where Sierra Leone (14,124 cases; CFR = 28%) and Liberia (10,678 cases; CFR = 45%) reported the highest cases numbers, mainly due to the 2014–2016 western Africa outbreak. Crimean-Congo hemorrhagic fever (CCHF) outbreaks were reported from 31 studies in Africa, Asia and Europe, where Turkey reported the highest cases number (6,538 cases; CFR = 5%) and Afghanistan the last outbreak in 2016/18 (293 cases; CFR = 43%).

Regarding the 38 studies reporting results on treatments, most of them were non-randomized studies (mainly retrospective or non-randomized comparative studies), and only 10 studies were randomized controlled trials. For several VHFs, no specific investigational therapeutic option with strong proof of effectiveness on mortality was identified.

Conclusion

We observed that number of cases and CFR varied greatly across VHFs as well as across countries within each VHF. The number of studies on VHF treatments was very limited with very few randomized trials and no strong proof of effectiveness of treatment against most of the VHFs. Therefore, there is a high need of methodologically strong clinical trials conducted in the context of VHF.
Effectiveness of antimalarial drug combinations in treating concomitant urogenital schistosomiasis in malaria patients in Lambaréné, Gabon: A non-randomised event-monitoring study
Authors: Zoleko-Manego Rella , Okwu Dearie G. , Handrich Christian , Dimessa-Mbadinga Lia B. , Akinosho Malick A. , Ndzebe-Ndoumba Wilfrid F. , Davi Saskia D. , Stelzl Daniel , Veletzky Luzia , Kreidenweiss Andrea , Nordmann Tamara , Adegnika Ayola A. , Lell Bertrand , Kremsner Peter G. , Ramharter Michael , Mombo-Ngoma Ghyslain
Published: October 2022

Background

Urogenital schistosomiasis is prevalent in many malaria endemic regions of sub-Saharan Africa and can lead to long-term health consequences if untreated. Antimalarial drugs used to treat uncomplicated malaria have shown to exert some activity against Schistosoma haematobium. Here, we explore the efficacy on concomitant urogenital schistosomiasis of first-line recommended artemisinin-based combination therapies (ACTs) and investigational second-generation ACTs when administered for the treatment of uncomplicated malaria in Gabon.

Methods

Microscopic determination of urogenital schistosomiasis was performed from urine samples collected from patients with confirmed uncomplicated malaria. Egg excretion reduction rate and cure rate were determined at 4-weeks and 6-weeks post-treatment with either artesunate-pyronaridine, artemether-lumefantrine, artesunate-amodiaquine or artefenomel-ferroquine.

Results

Fifty-two (16%) out of 322 malaria patients were co-infected with urogenital schistosomiasis and were treated with antimalarial drug combinations. Schistosoma haematobium egg excretion rates showed a median reduction of 100% (interquartile range (IQR), 17% to 100%) and 65% (IQR, -133% to 100%) at 4-weeks and 6-weeks post-treatment, respectively, in the artesunate-pyronaridine group (n = 20) compared to 35% (IQR, −250% to 70%) and 65% (IQR, -65% to 79%) in the artemether-lumefantrine group (n = 18). Artesunate-amodiaquine (n = 2) and artefenomel-ferroquine combination (n = 3) were not able to reduce the rate of eggs excreted in this limited number of patients. In addition, cure rates were 56% and 37% at 4- and 6-weeks post-treatment, respectively, with artesunate-pyronaridine and no cases of cure were observed for the other antimalarial combinations.

Conclusions

Antimalarial treatments with artesunate-pyronaridine and artemether-lumefantrine reduced the excretion of S. haematobium eggs, comforting the hypothesis that antimalarial drugs could play a role in the control of schistosomiasis.

Trial Registration

This trial is registered with clinicaltrials.gov, under the Identifier NCT04264130.
Association between cognitive function and large optic nerve cupping, accounting for cup-disc-ratio genetic risk score
Authors: Kravets Sasha , Rupnow Rawan Allozi , Sethi Abhishek , Espeland Mark A. , Pasquale Louis R. , Rapp Stephen R. , Klein Barbara E. , Meuer Stacy M. , Haan Mary N. , Maki Pauline M. , Hallak Joelle A. , Vajaranant Thasarat Sutabutr
Published: October 2022

Purpose

To investigate if accounting for a cup-to-disc ratio (CDR) genetic risk score (GRS) modified the association between large CDR and cognitive function among women.

Design

This was a retrospective study using data from the Women’s Health Initiative.

Methods

Patients with glaucoma or ocular hypertension were excluded. Large CDR was defined as ≥ 0.6 in either eye. Cognitive function was measured by the Modified Mini-Mental State Examination (3MSE). We used the combined effects from 13 single nucleotide polymorphisms (SNPs) to formulate the GRS for CDR. We used logistic regression to investigate associations between weighted GRS and large CDR, then a linear regression to assess the association between weighted GRS and 3MSE scores, and between weighted GRS, CDR, and 3MSE scores, adjusted for demographic and clinical characteristics.

Results

Final analyses included 1,196 White women with mean age of 69.60 ± 3.62 years and 7.27% with large CDR. Mean GRS in women with and without large CDR was 1.51 ± 0.31 vs. 1.41 ± 0.36, respectively (p = 0.004). The odds of large CDR for a one unit increase in GRS was 2.30 (95% CI: (1.22, 4.36), p = 0.011). Adding the CDR GRS in the model with CDR and 3MSE, women with large CDR still had statistically significantly lower 3MSE scores than those without large CDR, yielding a predicted mean difference in 3MSE scores of 0.84 (p = 0.007).

Conclusions

Independent of the CDR GRS, women with large CDR had a lower cognitive function.
Design of a novel compact highly selective wideband bandstop RF filter using dual path lossy resonator for next generation applications
Authors: Abdul Rehman Muhammad , Khalid Sohail , Mushtaq Bilal , Idrees Muhammad
Published: October 2022

This article presents the design of a wideband bandstop RF filter intending to improve selectivity and compactness. Conventional bandstop filter topology with finite unloaded quality factor produces degraded bandstop filter performance due to dissipation loss. In the proposed filter design, a novel dual path Capacitive Coupled Step Impedance Resonator (CCSIR) structure is used to obtain an infinite stopband attenuation. A uniform impedance resonator is used in Path 1, whereas Path 2 contains a resonator that is twice coupled to the transmission lines. The electrical length of both paths is chosen to be out of phase, resulting in a high rejection level at higher frequencies. It has been analyzed that the selectivity can be improved by increasing the order of the dual coupled step impedance resonator. The proposed design produces a wideband BSF centered at 5.25 GHz with a high rejection level of 104.3 dB and fractional bandwidth of 58.5%. The results have demonstrated that the resonant frequencies are regulated by varying the electrical length of CCSIR. Moreover, it has been realized that out of phase signal cancellation due to the dual path is involved in producing the finite frequency transmission poles, which further enhances the filter selectivity. However, the same electrical performance can only be achieved from coaxial cavities and waveguides due to the high-quality factor. The proposed topology is fabricated and measured on a high-frequency microstrip substrate having a low-quality factor with a compact output and better electrical performance compared to coaxial cavities or waveguides. Due to its high electrical performance and small size, the proposed BSF is appropriate for 4G and 5G (FR1) applications. The measurement shows good concurrence with the full-wave EM simulated results. The fabricated prototype of third order BSF has a compact size of (0.7 × 0.77)λg at 5.25 GHz.
Anxiety and depression among patient’s companions during admission to the ICU in the Omicron wave of COVID-19: A cross-sectional study in Aleppo University Hospital
Authors: Swed Sarya , Kashkash Fateh , Shoib Sheikh , Shaheen Nour , Nasif Mohamad Nour , Motawea Karam R. , ElHawary Ahmed Sallam , AbdelQadir Yossef Hassan , Patwary Muhammad Mainuddin , Alibrahim Hidar , Sawaf Bisher , Khairy Lina Taha , Bakkour Agyad , Muwaili Ali Hadi Hussein , Muwaili Dhuha Hadi Hussein , Abdelmajid Fatima Abubaker Abdalla , Elkalagi Nashaat Kamal Hamdy , Elsayed Mohamed , Ahmed Eman Mohammed sharif , Khouri Abdullah ,   Data Collection group
Published: October 2022

Background

After the COVID-19 pandemic, anxiety and depression have reached high levels, especially after the last wave, Omicron. Healthcare workers in contact with COVID-19 patients or those who come in contact with them may exhibit high levels of anxiety and depression. Therefore, we aimed to assess anxiety and depression symptoms among ICU companions of COVID-19 patients.

Methods

From 30 November 2021 to 1 March 2022, sixth-year medical students at Aleppo University Hospital conducted interviews with the companions of COVID-19 patients who they brought their patient to the ICU centre as part of a cross-sectional quantitative study using the PHQ-9 and GAD-7 tools to gauge their level of anxiety and depression among companions of COVID-19 patients. The data were analyzed using the SPSS program. In addition, logistic regression models were used to study possible factors of anxiety and depression symptoms during COVID-19.

Results

The total number was 997 participants in contact with COVID-19 patients. The mean score of the depression assessment tool (PHQ-9) in our questionnaire was 9.5 with a range of 0 to 27. At the same time, the anxiety assessment tool (GAD-7) had a mean score of 9.1, ranging from 0 to 21. A binary logistic regression was used to predict the relationship between depression and anxiety and various factors. We found that the companions with medical specialties were substantially less likely to develop anxiety than other companions [AOR = 0.459; 95%CI (0.23–0.9)], in addition females were substantially higher likely to develop depression than males [AOR = 1.322; 95%CI (0.992–1.762)]. 45.4% of companions had moderate to severe anxiety, in additon 50.8% of companions had moderate to severe depression.

Conclusion

Our research reveals that moderate to severe anxiety and sadness are present in roughly half of the COVID19 patients’ companions. Females, people with children, and hard workers were more inclined to feel anxious than others, and those who are not in the medical field were more likely to suffer from depression than others, thus it is critical to assist these groups during the present outbreaks (Omicron and Monkeybox).
Radiation vs surgery for early-stage laryngeal verrucous carcinoma: A population-based propensity score matched-study
Authors: Takenaka Yukinori , Uno Atsuhiko , Tanaka Hidenori , Takemoto Norihiko , Nozaki Kengo , Inohara Hidenori
Published: October 2022

Background

Verrucous carcinoma (VC) is a rare variant of squamous cell carcinoma. Although VC is considered radioresistant, concrete evidence for this is absent.

Methods

We obtained data on VC treated with surgery or radiation from the Surveillance, Epidemiology, and End Results database. Treatment selection bias was reduced by propensity score matching. Overall survival (OS) and disease-specific survival (DSS) rates were estimated using the Kaplan-Meier method. Hazard ratios (HRs) were estimated using Cox proportional hazards models.

Results

Five-year OS rates in the radiation and surgery groups were 72.7% and 72.0%, respectively (P = 0.111); five-year DSS rates in the same were 86.7% and 88.4%, respectively (P = 0.234). HRs of radiation compared with surgery were 1.68 (95% confidence interval (CI), 0.96–2.95) for OS and 1.95 (95% CI, 0.69–5.53) for DSS.

Conclusions

Similar prognoses were observed in patients with VC treated with radiation and surgery. VC can be treated using radiation.
Integrated analysis of lncRNA and gene expression in longissimus dorsi muscle at two developmental stages of Hainan black goats
Authors: Gu Lihong , He Qijie , Xia Wanliang , Rong Guang , Wang Dingfa , Li Mao , Ji Fengjie , Sun Weiping , Cao Ting , Zhou Hanlin , Xu Tieshan
Published: October 2022

It is deemed that meat quality of kids’ is better than that of adults’ for Hainan black goat. Generally, meat quality is affected by many indicators, such as intramuscular fat (IMF) content, muscle fiber diameter and shear force. It is indicated that long non-coding RNAs (lncRNAs) play essential roles in meat quality of goats. However, it is unclear whether and how lncRNAs and genes play their roles in meat quality of Hainan Black goats. Here, we firstly compared the meat quality between two-month-old kids (kids) and adult goats (adults). Then, the lncRNA-seq and RNA-seq data were integrated and analyzed to explore the potential functions of lncRNAs and genes. The results showed that adults’ IMF content and muscle fiber diameter were extremely significantly higher than that of kids (P<0.01). For the sequenced data, average 84,970,398, and 83,691,250 clean reads were obtained respectively for Kids and adults, among which ~96% were mapped to the reference genome of goats. Through analyzing, 18,242 goat annotated genes, 1,429 goat annotated lncRNAs and 2,967 novel lncRNAs were obtained. Analysis of differential expression genes (DEGs) and lncRNAs (DELs) showed that 328 DEGs and 98 DELs existed between kids and adults. Furthermore, functional enrichment analysis revealed that a number of DEGs and DELs were mainly associated with IMF. Primarily, DGAT2 expressed higher in adults than that in kids and CPT1A expressed higher in kids than that in adults. Both of them were overlapped by DEGs and targets of DELs, suggesting the two DEGs and the DELs targeted by the two DEGs might be the potential regulators of goat IMF deposition. Taken together, our results provide basic support for further understanding the function and mechanism of lncRNAs and genes in meat quality of Hainan black goats.
Wind velocity field estimation from aircraft derived data using Gaussian process regression
Authors: Marinescu Marius , Olivares Alberto , Staffetti Ernesto , Sun Junzi
Published: October 2022

Wind velocity field knowledge is crucial for the future air traffic management paradigm and is key in many applications, such as aircraft performance studies. This paper addresses the problem of spatio-temporal windc velocity field estimation. The north and east wind components within a given air space are estimated as a function of time. Both wind velocity field reconstruction in space for a past or present time instant and short-term prediction are performed. Wind data are obtained indirectly from the states of the aircraft broadcast by the Mode-S and ADS-B aircraft surveillance systems. The Gaussian process regression method, which is a flexible and universal estimator, is employed to solve both problems. Under general conditions, the method is statistically consistent, meaning that the method converges to the ground truth when increasingly more data are available, which is especially interesting, since aircraft data availability is expected to grow in the future through the deployment of the European System-Wide Information Management. Besides estimation, the Gaussian process regression method provides the probability distribution of any particular estimate, allowing confidence intervals to be computed. Moreover, the spatial modelling is performed using raw data without relying on grids and estimation can be performed at any spatio-temporal location. Furthermore, since the training phase of the method described in this paper is fast, requiring less than 5 minutes on a standard desktop computer, it can be used online to continuously track the state of the wind velocity field, thus allowing for data assimilation. In the case study presented in this paper, the Gaussian process regression method is tested on different days with different wind intensities. The available data set is split into several training and testing data sets, which are used to check the consistency of the results of wind velocity field reconstruction and prediction. Finally, the Gaussian process regression method is validated using the European Centre for Medium-Range Weather Forecasts ERA5 meteorological reanalysis data. The obtained results show that Gaussian process regression can be used to reliably estimate the wind velocity field from aircraft derived data.
A PCR-free rapid protocol for one-pot construction of highly diverse genetic libraries
Authors: Woolley Michael , Chen Zhilei
Published: October 2022

In vitro protein display methods can access extensive libraries (e.g., 1012–1014) and play an increasingly important role in protein engineering. However, the preparation of large libraries remains a laborious and time-consuming process. Here we report an efficient one-pot ligation & elongation (L&E) method for sizeable synthetic library preparation free of PCR amplification or any purification steps. As a proof of concept, we constructed an ankyrin repeat protein templated synthetic library with 1011 variants in 150 μL volume. The entire process from the oligos to DNA template ready for transcription is linearly scalable and took merely 90 minutes. We believe this L&E method can significantly simplify the preparation of synthetic libraries and accelerate in vitro protein display experiments.
Production of forest seedlings using sewage sludge and automated irrigation with ozonated cattle wastewater
Authors: de Oliveira Silva Laiz , Mendonça Henrique Vieira , Conforto Bruno Antonio Augusto Faria , Pinto Marinaldo Ferreira , Carvalho Daniel Fonseca de
Published: October 2022

The large volume of effluents generated by intensive cattle production can become an environmental problem, requiring solutions that combine treatment and disposal of reuse water. The quality of cattle wastewater (CWW) treated by ozonation, the water requirement and its effect on the growth of seedlings of Dalbergia nigra cultivated with sewage sludge were determined under different light conditions. The study was carried out in a split plot scheme with 2 shading levels (0%—C1, and 49.4% attenuation—C2) and 3 types of irrigation water (control–T1, 1 h ozonation–T2, and 2 h–T3), with 4 repetitions. Direct sowing was realized into 280 cm3 tubes which were irrigated by drip irrigation with automatic management. The height and collar diameter were measured every 21 days, and at the end of the nursery phase, and the Dickson quality index (DQI) and irrigation water productivity (WPir) were determined. In addition, seedlings were transplanted in a forest restauration area (FRA) of Atlantic Forest, with height and diameter monitoring for 200 days. With ozonation, there was an increase in pH and a reduction in electrical conductivity, total solids and turbidity in the CWW, allowing its use for irrigation of forest seedlings. The maximum volumes of water applied were 2.096 and 1.921 L plant-1, with water supply T2 and T1, respectively, and coverages C1 and C2. In these conditions, the seedlings reached DQI of 0.47 and 0.17, and WPir of 2.35 and 1.48 g L-1, respectively. The initial vegetative growth of the seedlings planted in the FRA was benefited by the nutrients provided by the CWW treated. Therefore, the use of sewage sludge and CWW treated has the potential to produce forest seedlings, reducing the release of waste and effluents into the environment.
Metabolic disorders and post-acute hospitalization in black/mixed-race patients with long COVID in Brazil: A cross-sectional analysis
Authors: Barreto Ana Paula Andrade , Barreto Filho Marcio Andrade , Duarte Lucimeire Cardoso , Cerqueira-Silva Thiago , Camelier Aquiles , Tavares Natalia Machado , Barral-Netto Manoel , Boaventura Viviane , Lima Marcelo Chalhoub Coelho ,   on behalf of the CPC study group
Published: October 2022

Background

Although low-middle income countries have been disproportionately affected by the COVID-19 pandemic, there is scarce information about the impact of long COVID on their population. This study aimed to evaluate long COVID symptomatology, complications (hospital readmission and metabolic disorders), and main clinical features that impact Quality of Life (QoL).

Methods

This cross-sectional study provides a detailed clinical and laboratory picture of individuals who presented residual symptoms after mild to severe acute COVID-19. Between Aug-2020 to Sep-2021, long COVID patients were evaluated in a reference center for long COVID in Bahia State, Brazil. The EQ-5D-5L questionnaire accessed QoL.

Results

A total of 1164 (52 ±13.4 years, 57% female, 88% black/mixed-race) were evaluated 2.3 [IQR = 1.6–3.7] months after mild (n = 351, 30.2%), moderate (338, 29.0%) or severe (475, 40.8%) acute illness. Dyspnea (790, 67.9%), fatigue (738, 63.5%), and chest pain (525, 42.9%) were the most frequent residual symptoms regardless of acute severity, affecting the QoL of 88.9% of patients (n/N—826/925), mainly the domains of anxiety/depression and pain/discomfort. High levels of HbA1c were detected for 175 out of 664 patients (26.6%), 40% of them without a previous diagnosis of diabetes mellitus. Of note, hospital admission one-to-three months after the acute phase of disease was required for 51 (4.4%) patients.

Conclusion

In this majority-black/mixed-race population, long COVID was associated with post-acute hospitalization, newly diagnosed diabetes mellitus, and decreased QoL, particularly in women and regardless of disease severity of acute infection, suggesting important implications for health care system.
Inequality and fairness with heterogeneous endowments
Authors: Tsvetkova Milena , Vuculescu Oana , Dinev Petar , Sherson Jacob , Wagner Claudia
Published: October 2022

People differ in intelligence, cognitive ability, personality traits, motivation, and similar valued and, to a large degree, inherited characteristics that determine success and achievements. When does individual heterogeneity lead to a fair distribution of rewards and outcomes? Here, we develop this question theoretically and then test it experimentally for a set of structural conditions in a specific interaction situation. We first catalogue the functional relationship between individual endowments and outcomes to distinguish between fairness concepts such as meritocracy, equality of opportunity, equality of outcomes, and Rawl’s theory of justice. We then use an online experiment to study which of these fairness patterns emerge when differently endowed individuals can share their resources with others, depending on whether information about others’ endowments and outcomes is available. We find that while visible outcomes lessen inequality by decreasing the statistical dispersion of outcomes across the group, endowments need to be visible for better equality of opportunity for the most disadvantaged.