bluuebunny/crossref_metadata_2025 huggingface dataset:
(Post)Yugoslavian Music Press in Transition
Authors: Ajduk Marija , Milosavljević Ljubica , Banić Grubišić Ana
Published: January 2024

The development of the Internet and digital technologies has influenced the ever- greater migrations of printed content to the digital sphere (blogs, online media, Internet portals, social networks), which has also brought with itself changes in readers’ habits and in the concept and format of texts as wells. Music press is no exception in that respect. In the context of South European states, these processes coincide with the period of political, social, cultural and economic transition, giving rise to the development of numerous regional and local specific forms of popular culture. The existence of the SFRY as a shared state enabled the creation of an authentic cultural space, which continued to develop even after its disintegration. This paper endeavors to shed light on one segment of that local authenticity through an analysis of music press. The aim the authors of this paper aspire to achieve is the presentation of the development path of the printed media in the first place inthe Socialist Federal Republic of Yugoslavia, then in Serbia, as well as the reconstructions of the modality of the transformation of this media in the transition period from an anthropological perspective. The wish is to identify the perception and significance of music as a local culturalphenomenon through the qualitative analysis of the archival material and the available Internet sources as well, then to trace the cultural changes that have been going on over time as a result of global and local social and cultural turmoil. We do not refer to press only as the medium which has an informative role, but rather as the medium that reflects the local community’s attitudes, simultaneously constructing narratives on popular culture that are incorporated in our everyday life.
Embodiment of the Manhood in Folklore: Keeping Secret from Women in Azerbaijan in the Context of a Real and Virtual Social Environment
Authors: Guliyev Hikmet , Garayev Safa
Published: January 2024

This article investigates reasons for keeping secrets from women in real and virtual social environment of Azerbaijan through a manhood perspective. The investigation has revealed that the masculinity within the society creates the folklore patterns that prohibit the transfer of the secrets of this gender group to women and on the other hand, prohibit the connection of women with the male social environment.

The attitudes supporting manhood are not expressed directly in the folklore texts, but are articulated sporadically, yet their symbolic manifestations influence all the events in the text. In general, investigating the psychosocial complexes within folklore provides extensive opportunities for the study of creative facts in a projective context. In this article, the embodiment of manhood in folklore has been analyzed based on Azerbaijani fairy-tales, jokes and proverbs. The results of the research reveal that sharing a secret to a woman is constructed as deprivation of manhood in the socio-cultural environment of Azerbaijan.

In this article, the concept of the men’s keeping secrets from the women has also been investigated within the framework of the Azerbaijani-language virtual social environment. The examples from the Internet sources considering Azerbaijani folklore, which have recently become the cultural reality, have been selected and analyzed in order to explain manhood stereotypes. The results of the investigation show that unlike the traditional folklore facts, the concept of the men’s keeping secrets from the women in the virtual social environment is presented in a more ironic and comic manner. The urgency to examine manhood stereotypes in the context of humor and irony is explained through introducing the alternatives to the tradition and free attitude to the stereotypes of Internet folklore.
Assessment of information protection level against unauthorized access
Authors: Onyshchenko Svitlana , Yanko Alina , Hlushko Alina , Sabelnikova Polina
Published: January 2024

The object of research. The study considers an effective method of assessing the information protection level in a computer network against unauthorized access based on the security graph.

Investigated problem. Existing approaches to assessing the information protection level against unauthorized access have certain shortcomings: the real structure of computer networks is not taken into account, losses from unauthorized access are estimated in a monetary unit, which may not always be appropriate, the variability of modern cyber-attack scenarios and dynamic characteristics are not fully taken into account .

The main scientific results. The results of the study showed that the proposed method of assessing the information protection level against unauthorized access in computer networks based on the security graph allows for a more accurate description of information resources due to their characteristic vulnerabilities. Based on the calculations of the security indicators of individual resources and the security of all information in the computer network, the ranking of risks and, accordingly, information resources according to the degree of criticality for the organization's activities is carried out. Recommendations have been developed to ensure the necessary information protection level against unauthorized access in the computer network.

The area of practical use of research results. The results of the research can be used in practice in corporate computer networks of any organizations, since the proposed method for assessing the information protection level against unauthorized access is easily adapted to the specific needs of the organization, taking into account the specifics of its activities and business.

Innovative technological product. The results of the study created an innovative strategy for assessing the information protection level against unauthorized access, which increases the control of information security and the compliance of computer networks with existing eligibility criteria.

Scope of the innovative technological product. The results of the research and the created innovative strategies relate to the information security of computer networks of any organizations.
Cooking with ChatGPT and Bard: A Study on Competencies of AI Tools on Recipe Correction, Adaption, Time Management and Presentation
Authors: DEĞERLİ Ahmet Hakan , DEĞERLİ Ahmet Hakan , TATLISU Nevruz Berna
Published: January 2024

With its potential use in many areas including food and beverage sector, artificial intelligence has become one of the most prominent topics recently, partly due to the new AI tools. This study evaluates the competencies of ChatGPT (versions 3.5 and 4) and Bard in relation to food recipes by assigning tasks in five different areas: recipe correction, recipe adaptation, recipe detailing, time management, and presentation. The responses were then analyzed. It was observed that ChatGPT 4 outperformed the other tools in recipe correction, time management and presentation tasks while it gave similar results with ChatGPT 3.5 in recipe adaptation and recipe detailing tasks. Bard performed better than ChatGPT 3.5 in recipe correction but performed worse than both tools in all other tasks. Subsequent discussions highlighted the strengths and limitations of the tools. While these tools’ scores may not yet outperform a professional chef in the assigned tasks, they can be alternative and supportive assets in the gastronomy field considering their rapid response rates. Along with the potential use of the tools in tasks such as adapting recipes, managing time, and generating presentation ideas, the ongoing development and interaction of AI tools and related technologies could contribute significantly to the food industry in the future.
İkinci El Pazarlarında Üretim ve Satış Yapan Kadın Girişimcilerin Sürdürülebilir Pazarlamaya Etkileri: Köyceğiz İlçesi Örneği (The Effects of Women Entrepreneurs Producing and Selling in Second-Hand Markets on Sustainable Marketing: The Case of Koycegiz District)
Authors: GÜRCOŞKUN Figen , KUBAT Kadriye , AKDENİZ Arzu
Published: January 2024

Uluslararası birlikler, çevre sivil toplum kuruluşları, devletler gelecek kuşakların büyük sıkıntılar çekerek hayatlarını sürdürmek zorunda kalacaklarını küresel ortak platformlarda sürekli olarak dile getirmekte ve acil önlemler alınması yönünde çağrılarda bulunmaktadır. Bu bağlamda, ikinci el pazarları, birçok sektördeki atık miktarının düşürülmesine ve sürdürülebilir pazarlama kapsamında kullanılan bir kavram olan geri dönüşüme katkıda bulunabilecek bir unsur olarak değerlendirilmektedir. İkinci el pazarlarının işlevselliğinde ve sürdürülebilir pazarlamaya katkısında kadın girişimcilerin rolünün önemli olduğu düşünülmektedir. Bu çalışmada, ikinci el pazarların oluşumunda ve etkinliğinde kadın girişimcilerin rolü belirlenerek sürdürülebilir pazarlamaya katkıları incelenmektedir. Çalışmanın amacı ikinci el pazarlarda üretim ve satış yapan kadın girişimcilerin sürdürülebilir pazarlamadaki etkisini belirlemektir. Bu çalışmayla ikinci el pazarlarda hem sürdürülebilir pazarlama faaliyetlerinin hem de kadın girişimciliğinin daha etkin hale getirilmesi planlanmaktadır. İşgücü piyasasında dezavantajlı grupta bulunan kadınların kullandığı malzemeleri tekrar üreten konumuna getirmek çalışmanın hedeflerindendir. Araştırmanın bu yönleriyle, literatürdeki eksikliği gidermesi açısından özgün bir çalışma olduğu düşünülmektedir. Çalışmada nitel araştırma yöntemi kullanılmıştır. Çalışmanın bu alanda girişimde bulunmak isteyen ancak cesaret edemeyen potansiyel kadın girişimcileri de harekete geçireceği ve onlara ışık tutacağı varsayılmaktadır.
Turistlerin Finansal Memnuniyeti ile Finansal Tavsiye Almalarının Finansal Yetenekler Aracılığıyla Tavsiye Etme Niyetlerine Etkisinde Sosyal Medyanın Düzenleyiciliği (The Moderating Effect of Social Media on the Effect of Tourists Financial Satisfaction and Receipt of Financial Advice on Their Intention to Recommend through Financial Capabilities)
Authors: BOZ Nurgül , AHMETOĞULLARI Kayhan
Published: January 2024

Bu çalışma Alanya ilçesine gelen Rus, Alman, İngiliz ve Polonyalı turistlerin finansal memnuniyet, finansal tavsiye, finansal yetenek ve tavsiye etme niyetleri arasındaki ilişkide sosyal medya kullanımının düzenleyicilik rolünü incelemektedir. Araştırma amacına ulaşmak için Alanya’ya gelen 261 turiste Almanca, Rusça, İngilizce ve Lehçe olmak üzere dört farklı dilde anket dağıtılmıştır. Verilerin analizinde doğrulayıcı faktör analizi, korelasyon analizi ve regresyon analizinin yanı sıra Heyes Model 59 testinden yararlanılmıştır. İki farklı modelde Model 59 sonuçları raporlanmış aracının düzenleyicisi sonuçları elde edilmiştir. Araştırma sonucunda finansal tavsiyenin finansal yetenekler aracılığıyla tavsiye etme niyetine etkisini ölçen model anlamlı bulunmuştur. Ayrıca finansal tavsiyenin finansal yetenekler aracılığıyla tavsiye etme niyeti arasındaki ilişkide sosyal medyanın güçlü bir düzenleyici rolü bulunmuştur. Bununla birlikte finansal memnuniyetin finansal yetenekler aracılığıyla tavsiye etme niyetine etkisini ölçen model anlamlı çıksa bile sosyal medyanın düzenleyiciliğine rastlanmamıştır. Araştırmada son olarak finansal tavsiye almanın finansal memnuniyeti artırdığı sonucuna ulaşılmıştır.
Desain Bangunan dan Fasilitas Restoran Ramah Keluarga dan Relevan dengan Budaya Urban Kota Denpasar
Authors: Dewi Ni Made Emmi Nutrisia , Rahayu Ni Nyoman Sri , Pranajaya I Kadek , Jantika Kadek Abe
Published: January 2024

Title: The Design of Buildings and Restaurant Facilities that are Family Friendly and Relevant to the Urban Culture of Denpasar
 
The urban community's demand to bring families to visit restaurants is significantly high. The on-site phenomenon indicates that the building designs of several restaurants in Denpasar have not maximally met the needs of the urban community, especially for families. Therefore, research is required to analyze restaurants' facilities and building designs to align with the needs of families and urban culture in Denpasar. The method employed is a qualitative descriptive method. The research results showcase the case study objects of several favorite restaurants in Denpasar, indicating that some already meet the needs of the urban community but need to be adjusted to align with current needs. The findings show that some restaurants are not in line with urban culture due to insufficient attention to the needs of the urban community. Issues related to spatial completeness and arrangement, availability of specific facilities, furniture design, and cleanliness of facilities contribute to this mismatch. The solution is to consider standard design, space, and security to meet needs, provide specific facilities, and implement the concept of green design. The contribution provided is in the form of input to ensure that restaurants are designed to adapt to the evolving needs of the urban community.
A PERCEPÇÃO DA POPULAÇÃO DE CASCAVEL QUANTO AOS INDICADORES DE SUSTENTABILIDADE
Authors: Teske Kamyla Taysa , Sales Juliana Augusta , Sinhorin Zimara Mariana , Bertolini Geysler Rogis Flor , Johann Jerry Adriani
Published: January 2024

Este estudo examinou como os residentes de Cascavel percebem os fatores de sustentabilidade no município, que foi classificado como a segunda melhor cidade para se viver em 2020 pelo prêmio Cidades Excelentes. Para alcançar esse objetivo, foi conduzida uma pesquisa quantitativa exploratória, na qual 384 questionários foram distribuídos aos moradores através do Google Forms. A análise envolveu a criação de gráficos e tabelas de distribuição de frequência, além da análise bidimensional de relação entre duas variáveis, através do teste qui-quadrado. Através dessa análise, constatou-se que, apesar do reconhecimento do município com o prêmio em 2020, a população não observou mudanças significativas nos indicadores de sustentabilidade relacionados a áreas como meio ambiente, gestão de resíduos sólidos, recursos hídricos, energia e tecnologia. Entre esses indicadores que não foram bem avaliados se dão pela falta de conscientização da própria população e por falta de políticas públicas que incentivem a utilização consciente dos recursos ambientais. Como contribuição empírica, este estudo possibilita melhor avaliar como a população do município vem observando as mudanças nos últimos três anos em relação à sustentabilidade, colaborar para pesquisas futuras sobre a temática e contribuir para a compreensão da sustentabilidade urbana na cidade de Cascavel e em outras cidades.
Exploring the Potential Link between Aluminum-Containing Deodorants/Antiperspirants and Breast Cancer: A Comprehensive Review
Authors: Hangan Tony , Bjorklund Geir , Chirila Sergiu
Published: January 2024

The potential association between aluminum-containing deodorants/antiperspirants
and breast cancer has been investigated and debated. This paper comprehensively
analyzes existing literature to examine the evidence and provide insights into this relationship.
This comprehensive review discusses aspects related to the absorption and distribution
of aluminum compounds, its effects on the induction of oxidative stress, the estrogenic
activity of aluminum, and potential disruption of hormonal pathways, and the
potential role in breast cancer induction. Currently, available research, consisting of epidemiological
studies as well as clinical trials, together with meta-analyses and previously
published reviews conducted on identifying the relationship between aluminum-containing
deodorants/antiperspirants and the risk of breast cancer were also analyzed and
discussed. Societal factors, personal hygiene considerations, and lifestyle changes contribute
to the increased usage of antiperspirants, but they do not establish a direct causal
connection with breast cancer. Further research employing larger-scale studies and rigorous
methodologies must validate the existing findings and explore the underlying mechanisms
involved. Continued multidisciplinary research efforts and collaboration between
researchers, regulatory bodies, and public health authorities are vital to developing a
more definitive understanding of this complex topic.
Gossypol Acetic Acid Alleviates the Ferroptosis of Chondrocytes in
Osteoarthritis by Inhibiting GPX4 Methylation
Authors: Shang Jing J. , Xiong Chenwei , Jiang Wei , Yu Zhentang , Zhang Junjie , Zhang Yi , Han Long , Miao Kaisong , Yu Changlin , Huang Yong , Zhou Xindie
Published: January 2024

Background:

Osteoarthritis (OA) is a chronic joint disease, usually accompanied by degeneration of the articular cartilage, fibrosis, bone hyperplasia around the joint, and damage to the
entire articular surface. Gossypol is a natural phenolic compound isolated from the seed of cotton
plants, and gossypol acetic acid (GAA) is a medicinal form of Gossypol. Recently, various biological activities of GAA, including anti-inflammatory and anti-tumor effects, have been widely reported. However, its effect on chondrocytes in OA has yet to be determined.

Methods:

In this study, we investigated the effect of GAA on ferroptosis in OA chondrocytes. The
effect of GAA on the cell viability and cytotoxicity of chondrocytes in rat cells was investigated
using CCK8. Western blotting, Reverse-transcription PCR (RT-PCR), and immunofluorescence
staining were used to elucidate the molecular mechanisms and signaling pathways of GAA inhibition of ferroptosis in OA chondrocytes. The effect of GAA on reactive oxygen species (ROS) production and lipid peroxidation levels in chondrocytes was examined using dihydroethidium (DHE) staining and fluorescent dye BODIPY581/591 C11. in vivo, micro-CT imaging, hematoxylin
and eosin staining, Safranin O-Fast staining, and immunohistochemistry were performed to evaluate the effects of GAA on OA cartilage.

Results:

The results showed that GAA treatment regulated the expression of chondrocyte extracellular matrix (ECM) related factors, including ADAMTS5, MMP13, SOX9, Aggrecan, and
COL1A2 and reduced the ROS and lipid peroxidation levels. Besides, Erastin could reverse the effects of GAA on chondrocytes. Similar to GAA, 5-AZA caused the reduction of ROS and lipid
peroxidation levels and reversed the effect of IL-1β on the expression of ECM-related factors in
OA chondrocytes. The above results clarified that GAA alleviated the ferroptosis of chondrocytes
in OA by inhibiting GPX4 methylation.

Conclusion:

Our findings revealed that GAA might be developed as a drug for treating OA clinically.
Development and Validation of the Diagnostic Model of 7 Gene in Endometriosis
Authors: Zhu Ruofei , Liu Yaqiong , Zhou Jie , Lv Zi , Shi Kun , Xiong Jian
Published: January 2024

Aims:

To explore the diagnostic biomarkers for diagnosing endometriosis.

Background:

Endometriosis is a benign, progressive, estrogen-dependent gynecological disorder
that has highly variant prevalence. Therefore, it is essential to develop reliable diagnostic biomarkers
for endometriosis diagnosis.

Objective:

To explore the diagnostic biomarkers for endometriosis diagnosis.

Methods:

Based on transcriptome data from GSE145701, we identified potential therapeutic targets
through the intersection of endometriosis-related genes from weighted gene correlation network
analysis (WGCNA) and differential expression analysis. Aprotein-protein interaction (PPI)
was constructed. Gene Ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG)
were employed for functional enrichment analysis. The intersection of hub genes from topological
analysis and module genes from module-based network analysis were selected as core targets,
which were used for diagnostic model construction. Its robustness was validated using GSE7305
and GSE134056. Associations of core targets with immune characteristics and pathways were further
evaluated. Molecular docking was employed to evaluate the docking affinity between core targets
and drugs. Additionally, western blot and quantitative real-time polymerase chain reaction
were also carried out to validate molecular docking results.

Results:

A diagnostic model was constructed using 7 core targets, which had a high diagnostic
ability for endometriosis. CTSK was positively correlated with immune scores, while CDH2 was
negatively correlated with immune scores. CTSK, HGF, and EPCAM were positively correlated
with energy metabolism and inflammation-related pathways, while RUNX2, FN1, NCAM1, and
CDH2 were positively correlated with epithelial-to-mesenchymal transition (EMT) and unfolded
protein response (UPR). Moreover, FN1 had good docking affinity with Elagolix, Esmya, and
Proellex. NCAM1 might be a promising target modulated by Elagolix. In vitro experiment revealed
that the expression of FN1 in human normal endometrial cell lines (hEEC) gradually decreased
with the increase of Esmya concentration, indicating that FN1 was a target for Esmya.

Conclusion:

These results may facilitate the in-depth understanding of the development of endometriosis,
and guide early diagnostic as well as clinical treatments for patients with endometriosis.
Quercetin Promotes the Repair of Mitochondrial Function in H9c2 Cells
Through the miR-92a-3p/Mfn1 Axis
Authors: Li Fen , Li Dongsheng , Yan Xisheng , Zhu Fen , Tang Shifan , Liu Jianguang , Yan Jie , Chen Haifeng
Published: January 2024

Objective:

Cardiocerebrovascular disease is a severe threat to human health. Quercetin
has a wide range of pharmacological effects such as antitumor and antioxidant. In this study,
we aimed to determine how quercetin regulates mitochondrial function in H9c2 cells.

Methods:

An H9c2 cell oxygen glucose deprivation/reoxygenation (OGD/R) model was constructed.
The expression of miR-92a-3p and mitofusin 1 (Mfn1) mRNA in the cells was detected
using reverse transcription-quantitative polymerase chain reaction (RT-qPCR). Changes in the
mitochondrial membrane potential of cells were examined by JC-1 staining. ATP production in
the cells was detected using a biochemical assay. Mitochondrial morphological changes were
observed using transmission electron microscopy. Detection of miR-92a-3p binding to Mfn1 was
done using dual luciferase. Western blotting was used to detect the protein expression of Mfn1 in
the cells.

Results:

miR-92a-3p is essential in regulating cell viability, apoptosis, and tumor cell metastasis.
OGD/R induced miR-92a-3p expression, decreased mitochondrial membrane potential and mitochondrial
ATP production, and increased mitochondrial damage. Mitochondria are the most
critical site for ATP production. Continued opening of the mitochondrial permeability transition
pore results in an abnormal mitochondrial transmembrane potential. Both quercetin and inhibition
of miR-29a-3p were able to downregulate miR-29a-3p levels, increase cell viability, mitochondrial
membrane potential, and ATP levels, and improve mitochondrial damage morphology.
Furthermore, we found that downregulation of miR-29a-3p upregulated the protein expression of
Mfn1 in cells. Additionally, miR-92a-3p was found to bind to Mfn1 in a luciferase assay. miR-
29a-3p overexpression significantly inhibited the protein expression level of Mfn1. Quercetin
treatment partially reversed the effects of miR-29a-3p overexpression in H9c2 cells.

Conclusion:

Quercetin promoted the recovery of mitochondrial damage in H9c2 cells through
the miR-92a-3p/Mfn1 axis.
IL-1β-Stimulated Bone Mesenchymal Stem Cell-Derived Exosomes Mitigate Sepsis through Modulation of HMGB1/AKT Pathway and M2 Macrophage Polarization
Authors: Li Yang , Sun Zifa , Li Yuanyuan , Sun Jing , Chen Biquan
Published: January 2024

Background:

Sepsis is a life-threatening disease caused by infection, and
developing novel strategies against sepsis is still required. Exosomes derived from
mesenchymal stem cells (MSCs) have shown promising therapeutic potential for
various diseases. In this study, we aimed to investigate the action and mechanism of
exosomes derived from IL-1β-pre-conditioned bone marrow-derived mesenchymal
stromal cells (BMSCs) in sepsis.

Methods:

Exosomes were isolated from BMSCs that were pretreated with (IL-1β-
BMSC/exos) or without IL-1β (BMSC/exos). In vitro, a cell model of sepsis was
induced by treating human umbilical vein endothelial cells (HUVECs) with
lipopolysaccharide (LPS), while in vivo, a sepsis model was established through cecal
ligation and puncture (CLP) operation. Immunofluorescence staining was used to
detect the uptake of exosomes by HUVECs. The effects of exosomes on the cellular
function of HUVECs were determined through EDU proliferation assay, migration
assay, and tube formation assay. Gene and protein expression were analyzed using
qRT-PCR, Western blot, ELISA, immunofluorescence staining, and immunohistochemistry
staining.

Results:

IL-1β-BMSC/exos significantly enhanced the proliferation, migration, and
tube formation of HUVECs. Treatment with LPS induced the expression of high
mobility group box 1 (HMGB1) and the phosphorylation of AKT in HUVECs, but these
effects were counteracted by the treatment of IL-1β-BMSC/exos. The protective effect
of IL-1β-BMSC/exos on the viability and tube formation ability of HUVECs was
reversed by overexpression of HMGB1. Moreover, IL-1β-BMSC/exos promoted the
polarization of M2 macrophages and reduced the secretion of inflammatory
chemokines. Additionally, IL-1β-BMSC/exos alleviated cecal ligation and puncture
(CLP)-induced sepsis in vivo.

Conclusion:

IL-1β-BMSC/exos alleviates sepsis by modulating the HMGB1/AKT
pathway and triggering M2 macrophage polarization.
Recent Progress in Free Radical Transformations of Allenamides
Authors: Liu Yongchun , Wang Zimin , Li Rui , Yao Yinhai , Shi Zhichuan , Sun Qin , Deng Guowei
Published: January 2024

Allenamides are special allenes, and the unique reactivity, selectivity (both stereoselective
and regionally selective) and stability of allenamides have been widely studied. In this
review, the development of the free radical transformation of allenamides over the last few years
will be summarized. This review discusses in detail in three parts: intermolecular radical addition
to C- X (X = N, S, O, Se) bonds, metal salt mediated cyclization of allenamides, and photocatalytic
cyclization of allenamides. In addition, reasonable details of the mechanisms are provided
for the vast majority of these transformations.
Clinical, Radiological, and Microbiologic Characteristics of Patients with Noncystic
Fibrosis Bronchiectasis in a Tertiary Center at Jordan
Authors: Albtoosh Asma S. , Altarawneh Tala , Toubasi Ahmad A. , Malek Mariam , Albulbol Dalia Mohammad , Alnugaimshi Sulaiman F. , Altarawneh Amro , Alsurkhi Raghad H. , Al Oweidat Khaled , Farah Randa I. , Obeidat Nathir , Salem Albtoush Eman Salameh
Published: January 2024

Background::

Only a small number of the investigations that were carried out in the Middle East attempted to characterize patients with NCFB. In order to
characterize patients with NCFB, as well as their etiologies, microbiological profiles, and outcomes, we therefore carried out this investigation.

Methods::

This retrospective cohort study was carried out at the Jordan University Hospital (JUH), a tertiary facility located in Amman, Jordan. Non-cystic
Fibrosis Bronchiectasis (NCFB) was defined as an HRCT scan typical for bronchiectasis along with a negative sweat chloride test to rule out cystic
fibrosis. Patients’ data were collected by the use of Electronic Medical Records (EMR) at our institution. Frequent exacerbation was defined as
more than 2 exacerbations in 1 year of the onset of the diagnosis.

Results::

A total of 79 patients were included, and 54.4% of them were female. The mean and standard deviation of the patient's age was 48.61 ± 19.62. The
etiologies of bronchiectasis were evident in 79.7% of the sample. Asthma, Chronic Obstructive Pulmonary Diseases (COPD), and Kartagener
syndrome were the most prevalent etiologies, accounting for related illnesses in 21.8%, 21.5%, and 13.9% of the patients, respectively. The most
frequent bacteria cultured in our cohort were Pseudomonas and Candida Species. Moreover, 43 patients of the study cohort were frequent
exacerbators, and 5 patients died.

Conclusion::

Our study supports the need to identify several bronchiectasis phenotypes linked to various causes. These findings provide information to clinicians
for the early detection and treatment of bronchiectasis in Jordan.
Differential Diagnostic Value of Two-dimensional Ultrasound Combined with
Three-dimensional Ultrasound Imaging Technology for Cesarean Scar
Pregnancy
Authors: Feng Chunyan , You Leiying , Zhu Xiaojuan
Published: January 2024

Background::

Cesarean scar pregnancy (CSP) refers to the phenomenon in which a fertilized egg implants and develops in the scar of the uterus in a woman with
a history of cesarean section.

Objective::

The study aimed to explore the differential diagnostic value of two-dimensional ultrasound (2D US) combined with three-dimensional ultrasound
(3D US) for CSP.

Methods::

Clinical data of 89 patients with CSP admitted to our hospital from January 2022 to January 2023 were retrospectively analyzed. Of them, 65
patients met the inclusion criteria. Patients underwent 2D US, 3D US, and combined 2D and 3D US imaging. Using the clinical pathological
diagnosis as the “gold standard”, the differential diagnostic value of 2D US, 3D US, and 2D US combined with 3D US for CSP was compared.

Results::

The detection rate of CSP using a combined 2D US and 3D US was 98.46%, which was higher than 84.62% and 89.23% achieved with 2D US and
3D US alone, respectively (P<0.05). The pathological results showed that among 65 patients, CSP type I accounted for 24.62%, type II accounted
for 55.38%, and type III accounted for 20.00%. The coincidence rate of 2D US combined with 3D US was 98.46%, which was higher than that of
2D US (83.08%) and 3D US 89.23%) alone (P<0.05). The accuracy, specificity, and sensitivity of 2D US combined with 3D US in diagnosing
CSP were higher compared to the two methods alone (P<0.05).

Conclusion::

The combination of 2D US and 3D US can accurately detect and classify CSP, further improving diagnostic efficiency.
Differential Diagnosis of Generalized Cystic Lymphangiomatosis: A Literature
Review
Authors: Keven Ayşe , Gürbüz Ahmet Faruk
Published: January 2024

Background::

Generalized cystic lymphangiomatosis (GCL) is a rare disease characterized by the widespread proliferation of lymphatic vessels, often seen in the
pediatric patient group. Imaging techniques are instrumental in revealing the extent and morphological features of the disease.

Objective::

The objective of this study is to interpret the radiological findings of GCL and address the differential diagnosis between GCL and other lymphatic
malformations in light of the relevant literature data.

Methods::

The sample of this retrospective study consisted of six pediatric patients, four males and two females, diagnosed with GCL based on clinical,
radiological, and histopathological findings between 2015 and 2022. The age of the patients at the time of diagnosis and their symptoms at
admission were obtained from the hospital database. Radiological imaging findings were evaluated in detail based on the involved systems (thorax,
abdomen, and musculoskeletal).

Results::

The median age of the sample, 4/6 were male, was 9 years at admission (min. 3, max. 12). The most common symptom at admission was dyspnea,
often accompanied by pleural effusion. Bone involvement was the most common extrathoracic finding. Abdominal involvement was primarily
asymptomatic, and the spleen was the most frequently involved organ in the abdomen.

Conclusion::

The diagnosis of GCL is challenging because of its rarity and overlapping diseases. Whole-body magnetic resonance imaging is a valuable tool as
it reveals the typical radiological features of GCL and how far it has spread throughout the body.
Mesenchymal Stem Cells Target Gastric Cancer and Deliver Epirubicin via Tunneling Nanotubes for Enhanced Chemotherapy
Authors: Zhou Yali , Li Yumin , Wang Haibin , Sun Haolin , Su Jing , Fan Yaqiong , Xing Wei , Fu Jie
Published: January 2024

Background:

A reduced effective local concentration significantly contributes to the
unsatisfactory therapeutic results of epirubicin in gastric cancer. Mesenchymal stem cells exhibit
targeted chemotaxis towards solid tumors and form tunneling nanotubes with tumor cells, facilitating
the delivery of various substances. This study demonstrates the novelty of mesenchymal stem
cells in releasing epirubicin into gastric cancer cells through tunneling nanotubes.

Objective:

Epirubicin delivery to gastric cancer cells using mesenchymal stem cells

Methods:

In vitro transwell migration assays, live cell tracking, and in vivo targeting assays were
used to demonstrate the chemotaxis of mesenchymal stem cells towards gastric cancer. We verified
the targeted chemotaxis of mesenchymal stem cells towards gastric cancer cells and the epirubicin
loading ability using a high-content imaging system (Equipment type:Operetta CLS). Additionally,
tunneling nanotube formation and the targeted release of epirubicin-loaded mesenchymal
stem cells co-cultured with gastric cancer cells through mesenchymal stem cell-tunneling nanotubes
into gastric cancer cells was observed using Operetta CLS.

Results:

Mesenchymal stem cells demonstrated targeted chemotaxis towards gastric cancer, with
effective epirubicin loading and tolerance. Co-culturing induced tunneling nanotube formation between
these cells. Epirubicin-loaded mesenchymal stem cells were released into gastric cancer
cells through tunneling nanotubes, significantly increasing their non-viability compared to the negative
control group (p < 0.05).

Conclusions:

We identified a novel approach for precisely targeting epirubicin release in gastric
cancer cells. Therefore, mesenchymal stem cell-tunneling nanotubes could serve as a potential
tool for targeted delivery of drugs, enhancing their chemotherapeutic effects in cancer cells.
Exosome-Derived Cargos in Immune Microenvironment in Esophageal Carcinoma: A Mini-Review
Authors: Zhang Yakun , Sun Xiaoyan , Guan Yan , Sun Ying
Published: January 2024

Esophageal carcinoma, a lethal malignancy with limited treatment options and poor
prognosis, necessitates understanding its underlying mechanisms and identifying novel therapeutic
targets. Recent studies have highlighted the critical role of the immune microenvironment
in esophageal carcinoma, particularly the interplay between tumor cells and immune cells mediated
by exosomes and their cargos. Exosomes, small extracellular vesicles secreted by various
cells, including tumor cells, facilitate intercellular communication by transferring bioactive
molecules such as proteins, nucleic acids, and lipids to recipient cells. In the context of esophageal
carcinoma, tumor-derived exosomes have been shown to play a significant role in shaping
the immune microenvironment. In esophageal carcinoma, exosomal cargos have been found to
modulate immune cell function and impact tumor progression. These cargos can carry immune
inhibitory molecules, such as programmed death-ligand 1 (PD-L1), to suppress T-cell activity
and promote immune evasion by tumor cells. Furthermore, exosomal cargos can activate antigen-
presenting cells, enhancing their ability to present tumor-specific antigens to T cells and
thereby promoting anti-tumor immune responses. Additionally, the cargos of exosomes have
been implicated in the induction of immune regulatory T cells (Tregs) and myeloid-derived
suppressor cells (MDSCs) within the esophageal carcinoma microenvironment. These immunosuppressive
effectors inhibit the activity of T cells, contributing to tumor immune evasion and
resistance to immune therapies. In summary, exosomes and their cargo play a crucial role in the
immune microenvironment of esophageal carcinoma. Understanding the mechanisms by which
exosomal cargos regulate immune cell function and tumor progression may reveal novel therapeutic
targets for this devastating disease.
Identification of Novel EGFR Inhibitors for the Targeted Therapy of Colorectal
Cancer Using Pharmacophore Modelling, Docking, Molecular Dynamic Simulation
and Biological Activity Prediction
Authors: Krishnan K. Amrutha , George Valavi Sudha , Joy Amitha
Published: January 2024

Background:

Colorectal cancer (CRC) is considered the second deadliest cancer in the world. One
of the reasons for the occurrence of this cancer is the deregulation of the Epidermal Growth Factor Receptor
(EGFR), which plays a critical role in regulating cell division, persistence, differentiation, and migration. The
overexpression of the EGFR protein leads to its dysregulation and causes CRC.

Objective:

Hence, this work aims to identify and validate novel EGFR inhibitors for the treatment of colorectal
cancer employing various computer aided techniques such as pharmacophore modeling, docking, molecular
dynamic simulation and Quantitative Structure-Activity Relationship (QSAR) analysis.

Methods:

In this work, a shared-featured ligand-based pharmacophore model was generated using the known
inhibitors of EGFR. The best model was validated and screened against ZincPharmer and Maybridge databases,
and 143 hits were obtained. Pharmacokinetic and toxicological properties of these hits were studied, and the
acceptable ligands were docked against EGFR. The best five protein-ligand complexes with binding energy less
than -5 kcal/mol were selected. The molecular dynamic simulation studies of these complexes were conducted
for 100 nanoseconds (ns), and the results were analyzed. The biological activity of this ligand was calculated
using QSAR analysis.

Results:

The best complex with Root Mean Square Deviation (RMSD) 3.429 Å and Radius of Gyration (RoG)
20.181 Å was selected. The Root Mean Square Fluctuations (RMSF) results were also found to be satisfactory.
The biological activity of this ligand was found to be 1.38 μM.

Conclusion:

This work hereby proposes the ligand 2-((1,6-dimethyl-4-oxo-1,4-dihydropyridin-3-yl)oxy)-N-
(1H-indol-4-yl)acetamide as a potential EGFR inhibitor for the treatment of colorectal cancer. The wet lab
analysis must be conducted, however, to confirm this hypothesis.
Evidence-based Practice Interventions for Reducing Postoperative Pulmonary Complications: A Narrative Review
Authors: Dhillon Gagandeep , Buddhavarapu Venkata S. , Grewal Harpreet , Munjal Ripudaman , Verma Ram Kishun , Surani Salim , Kashyap Rahul
Published: January 2024

Background:

Specific surgical procedures, such as upper abdominal and thoracic surgery, are connected to an increased predisposition of postoperative pulmonary complications (PPCs). The incidence of PPCs could vary approximately between 20-90% with upper abdominal surgery, which can be minimized by using treatment procedures that increase lung capacity and encourage inspiration. This review aims to examine the effectiveness of already existing evidence-based interventions that promote lung expansion, thereby preventing PPCs.

Method:

We mainly focused on the existing evidence of preoperative education on the incentive spirometer, early mobilization, directed coughing, deep breathing exercises, chest physiotherapy, and inspiratory muscle training (IMT) to prevent PPCs. The literature search was limited to experimental, observational studies, systemic reviews, and articles published in the last 15 years, January 2007- Dec. 2022, in PubMed and Google Scholar.

Result:

This initial search yielded a total of 5301 articles. All articles with titles not related to the topic were eliminated. 1050 records were screened, and the final review was conducted with 22 articles, including 13 randomized controlled trials (RCTs), four systemic reviews, one retrospective review, three observational studies, and one non-experimental study. Our review reveals mixed evidence for individual interventions, including but not limited to incentive spirometry, inspiratory muscle training, early mobilization, cough, deep breathing, etc. Some studies maintain that intervention is effective; others imply there is no substantial difference in the choice of intervention.

Conclusion:

The literature review concluded that patients who received multiple interventions showed significant improvement in pulmonary function postoperatively. However, definitive studies need to be conducted to solidify this conclusion.
Development and Evaluation of Dutasteride Nanoemulgel for the Topical
Delivery against Androgenic Alopecia
Authors: Alam Mahboob , Mishra Ajit , Yadav Kuldeep Singh , Pradhan Deepak , Kar Biswakanth , Ghosh Goutam , Rath Goutam , Rai Vineet  Kumar
Published: January 2024

Background:

Dutasteride is approximately three times more potent than finasteride in
treating alopecia. For reducing systemic exposure to dihydrotestosterone (DHT), researchers have
shown special interest in developing topical formulations for treating androgenic alopecia. Dutasteride
emulsification may lead to good skin penetration and improved availability in different lipophilic
skin environments.

Objectives:

This study aimed to encapsulate the drug into the lipidic carrier system for better local
availability in the scalp skin, develop and evaluate nanoemulgel of dutasteride to ensure efficient topical
administration, and perform the in-vivo activity of the developed gel for improved efficacy
against alopecia.

Methods:

Dutasteride-loaded nanoemulsion was prepared by a high-speed homogenizer, followed by
thickening of the dispersion using Carbopol 934. Skin permeation and accumulation were investigated
in the excised skin of male Swiss albino mice. The nanoemulgel was characterized based on pH,
stress stability, viscosity, and hardness.

Results::

The optimized dutasteride-loaded nanoemulsion had a size of 252.33 ± 8.59 nm, PDI of
0.205 ± 0.60, and drug content of 98.65 ± 1.78%. Stress stability was performed was well observed in
nanoemulsion formulation. Nanoemulgel evaluation results were as follows: pH 5-6 was desirable for
topical application, hardness was 43 gm, and spreadability was 79 gm with in vitro release of
nanoemulgel at 91.98% and permeation study at 13.67%.

Conclusion:

The in vivo studies demonstrated the growth of newer hair follicles and increased hair
diameter and length in dutasteride-loaded nanoemulgel-treated alopecia animals compared to the
marketed sample and testosterone-treated group. Provided with the same and long-term storage stability,
the developed formulation is supposed to offer a good option for the topical administration of dutasteride
in treating androgenic alopecia.The in vivo studies demonstrated the growth of newer hair follicles and increased hair
diameter and length in dutasteride-loaded nanoemulgel-treated alopecia animals compared to the
marketed sample and testosterone-treated group. Provided with the same and long-term storage stability,
the developed formulation is supposed to offer a good option for the topical administration of dutasteride
in treating androgenic alopecia.
Nonlinear Effects in Model Lattices of Metals
Authors: Starostenkov M.D.
Published: January 2024

The book presents an overview of nonlinear effects arising in discrete lattices of metals. Topics covered include discrete breathers, quasi-breathers, soliton waves, and shock waves.
Folklore use of Common Hydrophytes Found in and around ‘The Jagannath Temple’, Puri, Odisha
Authors: Shiva Prasad Mohanty  , Kshirabdhi Tanaya Rautaray  , Raka Jain
Published: January 2024

Background: Wetlands are rich in aquatic resource which maintains biodiversity and offers support to various aquatic lives. This atmosphere is generally supports hydrophytic plants or hydrophytes.[1] In India wetlands occupy 59.2 million hectres.[2] Puri is a coastal district of Eastern Odisha famous for “The Jagannath Temple” and associated ponds, wells and host of other ancient monuments along with long sea beaches and many rivers. Much survey has been done previously for hydrophytes in India and other districts of Odisha, but not much for Puri district. This work is important as many folklore practicing peoples are using various aquatic herbs for treatment purpose. Methodology: The study was conducted during 2022-2023, involving field visit, meeting with folklore practicing people and taking the photographs of plants for identification. The plants were identified based on The Flora of Odisha[3] and Botany of Bihar & Odisha[4] and contemporary monographs and reviews.[5,6] Results & Discussion: A total number of 36 species belonging to 22 families were documented and their supposed folklore medicinal uses have been recorded.
An open label single arm clinical study to evaluate the combined effectiveness of Navakashaya and Vidangadi Lepa in Vicharchika (Dermatitis)
Authors: E Dija T Lawrence , Girish K J  , Vasantha B  , Tapas Brata Tripathy
Published: January 2024

Background: Vicharchika is one among the Kshudra Kushta with predominance of Kapha Dosha and it is characterized by, Kandu (Itching), Bahu Srava (Excessive exudation), Shyava Varna (Greyish black discolouration) and Pidaka (Papule). Vicharchika is similar to Dermatitis (Eczema). Dermatitis is a heterogenous group of disorders that share similarities in clinical appearance and histopathologic findings, but may have different etiologies. Objectives: To evaluate the combined effectiveness of Navakashaya and Vidangadi Lepa in the management of Vicharchika (Dermatitis). Methods: Among 34 registered subjects, 30 of them completed the course of treatment. They were administered with Navakashaya internally and Vidangadi Lepa application externally for a period of 30 days. Ordinal data was analyzed with Friedman’s test followed by Wilcoxon signed rank test as post-hoc and Nominal data was analyzed with Cochran Q test followed by McNemar test as post-hoc. Continuous data was analyzed by Repeated Measures ANOVA and after applying bonferroni correction with Paired t test as post-hoc. Results: There was statistically significant improvement in the subjective and objective parameters of Vicharchika (Dermatitis). Conclusion: Navakashaya and Vidangadi Lepa are effective in the management of Vicharchika (Dermatitis).
Ayurvedic management of Alcohol Use Disorder
Authors: C N Nisha , Raviprasad Hegde
Published: January 2024

Substance use disorders are chronic relapsing disorders, leading to significant impairment in psychosocial functioning. Nicotine and alcohol are most widely consumed psychotropic drugs worldwide. The common use of both increases the risk of noncommunicable diseases to many folds. Conventional therapies have not been able to alter the outcome of these disorders significantly and frequent relapses continue to occur. Hence there is a need to look at complementary and alternate systems of medicine. Ayurveda remains one of the most ancient and yet living traditions practiced widely in India and has a sound philosophical and experiential basis. The planning of an effective adequate management of alcohol use disorder in Ayurveda with the aid of Ahara, Vihara, Achara and Aushadhi depends upon the strength of the disease (Roga) and the stamina of the patient (Rogi). Here is an attempt made to explain a case study of alcohol use disorder with holistic Ayurvedic management.
An Ayurvedic approach for management of Cervical Erosion - A Case Study
Authors: Swati Preeti Lagna  , Manjusri Sahoo
Published: January 2024

Amongst various gynecological disorders seen by gynecologists in day-to-day practice, cervical erosion forms a sizeable group (60-80%) especially in a country like ours due to its poor hygiene and nutritional status. It is a condition where columnar epithelium of the cervical canal proliferates downwards and encroaches over the squamous epithelium of the portio vaginalis around the external os. Though mostly it is influenced by over activity of ovarian hormones but it can also be due to some bacterial infections of the cervix or because of inflammation. There is no disease given in Ayurvedic classics which can be directly correlated with cervical erosion but the best analogue can be with Garbhasaya Greevagata Vrana. A 32 years old patient came to the out -patient division of the hospital with complains of excessive white discharge and backache since 4 months. She was treated with Ayurvedic Sthanik Chikitsa - Yoni Dhavan with Triphala Kasaya followed by Yoni Pichu with Sallakyadi Taila for 14 days. Significant improvement was noticed after the treatment and restricted disease progression was observed.