bluuebunny/crossref_metadata_2025 huggingface dataset:
Indigenous storage structures for paddy in North East region
Authors: Reema Kshetrimayum  , Ngankham Joykumar Singh
Published: September 2023

The effect of different indigenous storage methods on the quality of rice during the storage period was studied. Four different varieties of paddy were stored in different storage structures as indigenous types, such as Kot (small bamboo structures), Kei (large size storage structure), wooden structures and metal bins separately, and the total head rice recovery of rice during storage period was studied. The maximum head rice yield was found in the KD cultivar and the minimum in the Huikap cultivar. The different physical dimensions and characteristics of paddy influenced the breakage of paddy, affecting the total head rice recovery during storage. Long, slender grains are more susceptible to breakage, affecting the head yield.
Supporting Resource Sharing during COVID-19 with IFLA
Authors:   OA.Works
Published: September 2023

If your library’s ability to do resource sharing (i.e. ILL or document delivery) has been impacted by COVID-19, help is at hand. Interlibrary loan professionals at non-profit institutions can head to rscvd.org and volunteer librarians around the world will help to supply materials.
Daten als Wirtschaftsgut?
Authors: Schmidberger Miriam Bindel Annika Langhorst Jana
Published: September 2023

Online-Dienste kostenlos nutzen, aber mit Daten „bezahlen“, das gehört zum digitalen Alltag. Doch gerade personenbezogene Daten sind ein besonders sensibles Gut. Dessen Nutzung wird durch Datenschutzgesetze nicht verboten, aber klar reglementiert – zugunsten der Verbraucher*innen.
SWR-Archiv online: Audiovisuelle Dokumente für eine eindrückliche Beschäftigung mit der Geschichte
Authors: Steinhau Henry
Published: September 2023

Nach jahrelanger Vorarbeit begann der öffentlich-rechtliche Südwestrundfunk kürzlich damit, Archivbestände online zu stellen. Welchen Nutzen die Gesellschaft davon hat und was die Rundfunkarchive hemmt, sich zu öffnen, erläutert die SWR-Dokumentarin Rabea Limbach.
US-Gerichte: Led Zeppelin sowie Katy Perry haben (doch) nicht plagiiert
Authors: Steinhau Henry
Published: September 2023

In zwei international beachteten Copyright-Prozessen ging es auch darum, wie „originell“ bestimmte musikalische Sequenzen sein müssen, um urheberrechtlichen Schutz zu erhalten. Was die Entscheidungen für künftige Musikurheberrechts-Streits bedeuten, muss sich noch zeigen.
Betreiber, Störer, Nutzer: Wer haftet bei der WLAN-Nutzung?
Authors: Djordjevic Valie
Published: September 2023

Wer ein WLAN betreibt, muss unter Umständen verhindern, dass Rechtsverletzungen darüber stattfinden. Zwar wurde die Störerhaftung für öffentliche WLAN-Netze weitestgehend abgeschafft, doch noch sind nicht alle offenen Fragen geklärt. Wie können sich Anschlussinhaber absichern, welche Pflichten können sie weiterhin treffen?
Referentenentwurf des BMJV leitet entscheidende Phase für umfassende Urheberrechtsreform ein
Authors: iRights.info Redaktion
Published: September 2023

Mit dem Referentenentwurf des BMJV geht die Umsetzung der EU-Urheberrechtsrichtlinie in die entscheidende Phase. Das umfassende Reformpaket bietet in brisanten Fragen – Leistungsschutzrecht, Uploadfilter – neue „Kompromisslösungen“. Nun kommt es auch auf die öffentliche Diskussion an. Einen fairen Interessensausgleich – das soll der Gesetzesentwurf zur Umsetzung der EU-Urheberrechtsrichtlinie für alle Beteiligten bringen.
Kurt Caviezel: „Die Authentizität dieser Bilder finde ich extrem spannend“
Authors: Steinhau Henry
Published: September 2023

Der Schweizer Künstler Kurt Caviezel grast seit fast 20 Jahren das Internet nach offenen Webcams ab und speichert Millionen Standbilder. Seine Ausstellungen und Fotobücher liefern mitunter verblüffende, manchmal bestürzende Alltags-Einblicke – und werfen auch einige rechtliche Fragen auf.
Deutliches Signal gegen überhöhte Abmahnungen bei CC-lizenzierten Fotos
Authors: Steinhau Henry
Published: September 2023

Das Amtsgericht Würzburg hat in einem Streitfall um die fehlerhafte Nutzung eines creative-commons-lizenzierten Fotos entschieden, dass die Geldforderungen des abmahnenden Fotografen unberechtigt sind.
Unser digitales Korsett
Authors: Becker Maximilian
Published: September 2023

Digitaltechnik durchdringt sämtliche Lebensbereiche. So verleiht sie Anbietern wachsende Macht über die Nutzer. Dies führt den Gesetzgeber in Versuchung, von neuen Steuerungsmöglichkeiten Gebrauch zu machen und Recht zu industrialisieren. Dass Menschen sich an neue Technik anpassen müssen, ist ein alter Hut.
Urheberrecht für Lernende: Häufige Fragen und Antworten
Authors: Pachali David
Published: September 2023

Darf man Vorlesungen und andere Veranstaltungen aufzeichnen, veröffentlichen oder fremde Skripte ins Netz hochladen? Was sind Open Educational Resources, was ist Open Access? Wem gehören die Rechte an wissenschaftlichen Arbeiten? Antworten auf häufige Fragen zum Urheberrecht für Lernende. Das Urheberrecht ist häufig kompliziert genug, bei Bildung und Wissenschaft aber wird es noch komplexer.
Grundwissen-Workshops zu Freien Lizenzen und Creative Commons beim OERcamp in Lübeck
Authors: iRights.info Redaktion
Published: September 2023

Vom 13. bis 14. Juni findet das nächste OERcamp statt. Die zweitägige Veranstaltung auf dem Campus der Technischen Hochschule (TH) Lübeck richtet sich an Menschen aus allen Bildungsbereichen, die offene Bildungsmaterialien (Open Educational Ressourcen, OER) kennenlernen und nutzen, selbst erstellen oder verbreiten wollen.
Musik in Podcasts nutzen. Die GEMA-Lizenz und ihre Alternativen
Authors: Fischer Georg
Published: September 2023

Wer in Podcasts auch Musik einsetzen will, muss dafür Nutzungsrechte einholen. In vielen Fällen sind Vergütungen bei der GEMA erforderlich. Alternativ stehen GEMA-freie oder Creative Commons-lizenzierte Musikwerke zur Verfügung. Wir erklären, was man dabei beachten sollte und welche Kosten entstehen können.
Open COVID: Freie Lizenzen für offenes Wissen in der Coronakrise
Authors: Rack Fabian
Published: September 2023

Ein Zusammenschluss von Vertreter*innen aus Wissenschaft, Recht und Wirtschaft will rechtliche Hürden bei der Bekämpfung der Coronapandemie abbauen – mit einer neuen, auf die Krise zugeschnittenen Open-Content-Lizenz.
Webschau: EU-Urheberrechtsreform und Artikel 13 – pro und kontra
Authors: Djordjevic Valie
Published: September 2023

Der Streit um die neue Richtlinie zum EU-Urheberrecht tobt. Verwerter und manche Urheberverbände loben die Direktive, die Netzcommunity organisiert Petitionen und Demos. Aber es gibt auch Überraschungen. Eine Übersicht.  Das Ergebnis der Trilog-Verhandlungen zwischen EU-Kommission, -Rat und -Parlament für eine neue EU-Urheberrechtsrichtlinie liegt seit Mitte Februar 2019 vor.
Worum es beim Streit um Uploadfilter und Leistungsschutzrecht geht
Authors: Steinhau Henry
Published: September 2023

Auch nach dem Kompromiss zur neuen EU-Urheberrechtsdirektive geht der Streit weiter – in der EU wie auch unter Interessenvertretern. Insbesondere die zu erwartenden Uploadfilter und das Presse-Leistungsschutzrecht sorgen für Kontroversen. In rund vier Wochen entscheidet die finale Abstimmung des EU-Parlaments. Die EU-Richtlinie für ein neues digitales Urheberrecht steht.
Kinetics of BCR-ABL Transcripts in Imatinib Mesylate treated Chronic Phase CML (CPCML), A Predictor of Response and Progression Free Survival
Authors:   Molecular and Cell Biology Unit, Clinical Oncology center, School of Medicine, Cairo university, Egypt, El-Metnawy Wafaa , Mahmoud Hossam K , Moaty Mohamad Abdel , Fattah Raafat Abdel ,   Department of Hematology and BMT, Cairo University, Egypt, El Nahas Yasser ,   Department of Clinical Pathology, National Cancer Institute (NCI), Cairo University, Egypt, El Emary Mohamad ,   Department of Hematology, Nasser Institute, Ministry of Health, Egypt
Published: September 2023

Purpose: To assess the kinetics of molecular response to Imatinib Mesylate (IM) therapy in predicting progression free survival (PFS), sustained hematological, and cytogenetic responses in CPCML. Methods: Ninety five newly diagnosed CPCML Egyptian patients were treated with IM 400 mg daily dose. Cytogenetic analysis was performed at diagnosis and every 6 months. Molecular monitoring by RT-QPCR was performed at diagnosis and every 3 months during a median follow-up period ( FUp) of 26 months. Mutation detection of ABL domain was performed by ASO-PCR. Results: Hematological response was 98% after three months of IM therapy. Out of 95 patients 59 showed 2 log reduction of BCR-ABL/ABL ratio after 6 months of whom 49 (83%) had complete cytogenetic response (CCyR) and 42 (71%) had major molecular response (MMR) at 12 months. BCR-ABL transcripts remained undetectable in 22 patients (39%) at 26 months. Among the remaining 34 patients not achieving 2 log reduction at 6 months only 5 (15%) had CCyR and MMR by 12 months. ABL domain mutations were detected in 11/15 (73%) resistant and suboptimal responding patients. Achieving 2 log reduction after 6 months of IM therapy significantly correlated with sustained cytogenetic and molecular responses (p<0.0001), with PFS at 2 years (p<0.03) and inversely with ABL gene mutations (p<0.001). Discussion: These data demonstrated the predictive value of early molecular response to IM in CPCML regarding disease course and PFS. A 2 log reduction at 6 months of IM treatment could be a cut off level predicting resistance , CCyR, or suggesting IM dose modification.
Engineered FADD Induces Apoptosis via an Artificial Death-Inducing Signaling Complex (DISC)
Authors:   Laboratory of Pharmacogenomics, Graduate School of Pharmaceutical Sciences, Chiba University, 2-6-7 Kazusa-Kamatari, Kisarazu, Chiba, Japan, Nakayama Manabu , Suzuki Emiko ,   Department of Human Genome Research, Kazusa DNA Research Institute, 2-6-7 Kazusa-Kamatari, Kisarazu, Chiba, Japan, Takashina Tomoki ,   Laboratory of Pharmacogenomics, Graduate School of Pharmaceutical Sciences, Chiba University, 2-6-7 Kazusa-Kamatari, Kisarazu, Chiba, Japan
Published: September 2023

An engineered Fas-associated death domain protein (FADD), 2DEDplusE-made previously by fusing the tandem DEDs of FADD to the E protein of lambda phage-greatly enhances apoptosis-inducing activity in adherent cells in vitro. To investigate the mechanism of apoptosis-inducing activity of this engineered FADD, we compared the apoptosis-inducing activity of various other engineered FADDs. The tandem DED of 2DEDplusE contributed most to the enhancement of apoptosis, and the E protein contributed moderately. The engineered factor produced artificial death-inducing signaling complex (DISC)-like signals in the cytoplasm that appear as grains under fluorescence microscopy. Membrane blebbing associated with apoptosis was observed just after formation of grain-like signals. Immunoprecipitation analysis demonstrated that 2DEDplusE-FLAG can bind p43/p41 forms of caspase 8 but E protein-FLAG cannot. Gel filtration analysis demonstrated that 2DEDplusE forms a large complex containing partially cleaved procaspase 8 (p43/p41) in the cytoplasm; the size of this complex varies greatly. In the absence of an extrinsic signal, the engineered FADD formed artificial DISC in the cytoplasm, and then its tandem DED activated procaspase 8, which in turn executed apoptosis. The engineered FADD complex closely mimicked intrinsic DISC and increased apoptosis-inducing activity.
Spectrophotometric Determination of Labetalol and Lercanidipine in Pure Form and in Pharmaceutical Preparations Using Ferric-1,10-Phenanthroline
Authors:   Department of Medicinal Chemistry, Faculty of Pharmacy, University of Mansoura, Mansoura, Egypt, El-Wasseef Dalia Rashad , Abu El-Enin M. A. , El-Sherbiny D. T. , El-Ashry S. M.
Published: September 2023

A simple and sensitive spectrophotometric method was developed for the determination of labetalol HCl (LBT) and lercanidipine HCl (LER) in pure form and in dosage forms. The method was based upon oxidation of the LBT and LER with Fe+3 and the estimation of the produced Fe+2 with 1,10-phenanthroline. The absorbance of the tris(1,10-phenanthroline) Fe+2 complex was measured at 510 nm. Reaction conditions were optimized to obtain colored complex of higher sensitivity and longer stability. The absorbance concentration plots were rectilinear over the concentration rang of 5-90 and 1-20 μg/mL with lower detection limits of 0.74 and 0.01 μg/mL and quantification limits of 2.26 and 0.02 μg/mL for LBT and LER, respectively. The developed method was successfully applied for the determination of LBT and LER in bulk drugs and dosage forms. The common excipients and additives did not interfere in their determinations. There was no significant difference between the results obtained by the proposed and the reference methods regarding Student t-test and the variance ratio F-test.
A Common Polymorphism of Upstream Transcription Factor 1 Gene is associated with Lipid Profile: A Study in Chinese Type 2 Diabetes Families
Authors:   Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China, Hu Yonghua ,   Key Laboratory of Epidemiology, Ministry of Education, Beijing, China, Song Yan , Li Na , He Liu , Tang Xun , Chen Dafang
Published: September 2023

Upstream transcription factor 1 (USF1) is capable of controlling various members in glucose and lipid metabolism pathways. Much evidence suggests that the rs3737787 polymorphism in the USF1 gene may lead to alteration of lipid metabolism. The objective of this study was to test the association between rs3737787 and type 2 diabetes mellitus (T2DM) and its related lipid metabolic traits in the Chinese population. A total of 287 eligible T2DM families were chosen in Beijing. A set of questionnaires was administered to obtain information on demographic characteristics. Physical measurements were recorded. DNA was extracted from blood samples and genotyped using PCR-RFLP method. Statistical analyses including linkage analysis and family-based association test were performed to detect the relationship between rs3737787 and T2DM related traits. In the non-parametric linkage analysis, it was observed that rs3737787 is potentially linked with triglyceride and apolipoprotein E levels, where the logarithm of the odds scores were 0.87 (p=0.02) and 1.96 (p=0.001), respectively. Similar results were obtained in the multi-factorial generalized estimating equation analysis. Using different statistical approaches, in this study, we have confirmed that the single nucleotide polymorphism rs3737787 is related to triglyceride and apolipoprotein E levels in type 2 diabetes mellitus families.
The Ruling of Selling Vegetable Oil in Its Original State: An Islamic Jurisprudential Study
Authors: Alrayahneh Marwan , Azzam Hamad
Published: September 2023

This study aims to clarify the ruling on selling vegetable oil in its original state, particularly the sale of olive oil along with the olives in our country. The study includes two main inquiries: the first one focuses on presenting the opinions of scholars and their evidence regarding the sale of vegetable oil in its original state. The second inquiry addresses the possibility of analogizing the issue of selling oil in its original state to "Bay’a ala’raya" (the sale of a number of ripe dates that are still on the palm trees based on an estimation of the dates on the ground using dry measurement), with the application of legal preference. The study concludes that it is not permissible to analogize the issue of selling vegetable oil in its original state to Bay’a ala’raya, as the reason for the ruling does not apply in this context. Furthermore, the study finds that selling vegetable oil in its original state is not permissible according to Islamic jurisprudence, as they cannot be equated as the same category.
Renewing the Science of Theology in the Indian Subcontinent: Shibli An-Nu'mani as a Model
Authors: Soylu Davud , Alamoush Bassam
Published: September 2023

This study sheds light on the renewal of the science of theology in the Indian subcontinent, with Shibli An-Nu'mani as a model. The study begins by defining the science of theology and then explores the meaning of renewing the science of theology and its understanding and essence among Muslims. It further presents the emergence of the renewal of the science of theology and its manifestations in the Islamic world among Indians, Persians, Turks, and Arabs. The study also highlights the need for renewing the science of theology in modern times and how scientific developments, new discoveries, and modern materialistic philosophies have contributed to its renewal. Then the study presented Shibli An-Nu'mani’s views on renewing the science of theology. It started by discussing his perspective on modern sciences and their relation to religion. It then demonstrated how he approached traditional topics such as divinity, prophecy, reward, and punishment, employing new methods and a modern outlook that contributed to the renewal of the science of theology and its utilization in responding to modern doubts. The study also explored the modern subjects addressed by Shibli An-Nu'mani, such as human rights, women's rights, the issue of equality, progress, and development in Islam, and how he incorporated these topics into the new science of theology. The study has reached a set of results, the most important of which are: the idea of renewing the science of theology emerged among some scholars to dispel doubts about Islam, and Shibli An-Nu'mani was the first to use the term "renewal of the science of theology". He employed this renewal to strengthen the Muslims' beliefs, defend their religion, and respond to the doubts raised by atheists and opponents of Islam in a scientific manner, relying on scientific evidence.
The Scholars who were obscure to Al-Hafiz Ibn Hajar and Traced by Him in the Matters of Hadith in 'Hadi Al-Sari' and Revealed their Identities in 'Fath Al-Bari' Clarifying the Reason for the Obscurity
Authors: Al-Ali Haitham , Aouati Fatima
Published: September 2023

This research aims to identify the reasons that led Al-Hafiz Ibn Hajar to vaguely name some scholars in certain Hadith matters mentioned in the introduction of his book "Hadi Al-Sari," and then revealed their identities in his explanation "Fath Al-Bari." We have conducted a comprehensive study and followed the inductive approach to determine these names, enabling us to uncover a variety of reasons that prompted Ibn Hajar to do so, using an analytical methodology.
The clinical effectiveness of haptotherapy in routine practices
Authors: Bosscher Ruud , van Leeuwen Anne , Pluimers Cheraly
Published: September 2023

Despite the widespread application of haptotherapy in The Netherlands, there is a lack of evidence regarding its effectiveness. The aim of this study was to further explore its effect in a convenience sample of clients from first line clinical practices.
Haptotherapy and crying: an exploratory study
Authors: Klabbers Gert A. , Vingerhoets Ad J.J.M.
Published: September 2023

Background This study’s main aim was to understand better why patients cry during a haptotherapy treatment and whether crying is considered helpful. Method During a period of 4 weeks, Dutch haptotherapists asked all their patients aged 18 and older to complete a digital questionnaire at home after the end of the haptotherapy treatment. Patients were asked about their indication for haptotherapy, and they answered six questions about crying during therapy on a 5-point Likert scale (1-5). In addition, the participating haptotherapists were asked (1) whether they ever had tears in their eyes during therapy, (2) whether they had ever actually cried during therapy, and (3) whether they considered the patient’s crying as helpful for the therapeutic process. Results Seventy-two participating haptotherapists recruited 640 participants, 500 women and 140 men. The respondents’ average age was 46 years. The six most common indications (n > 30) were burnout complaints, stress complaints, personality development, depressive complaints, anxiety complaints, and comorbidity. During the haptotherapy treatments, 80.9 % (n = 518) of the patients reportedly had cried during therapy. Women cried significantly more often than men (t(638) = 7,922, p = .017). Crying during treatment did not differ between patient groups (F(5, 436) = .317, p = .903). Of the patients, 26.1 % (n = 167) indicated that they cried to let others know they were suffering, and 88.1 % (n = 564) because their crying had a relieving effect. The patient’s crying was perceived as meaningful by most patients (98.6 % (n = 631)) and therapists (62.5 % (n = 45)). As many as 43.1 % of the participating patients reported changes in general crying, with 27.3 % reporting an increase in their crying and 15.8 % a reduction. Conclusion Patient crying occurs relatively often during haptotherapy, as it does during other therapies. Most patients consider this as meaningful. The different patient diagnoses, the different educational backgrounds of the haptotherapists, and the sociodemographic differences did not influence patient crying. To further understand the effective mechanisms of haptotherapy, it is recommended to investigate why some patients cry more after haptotherapy and others cry less and how they experience their change in crying frequency.
Haptotherapy and empathy
Authors: Duyndam Joachim
Published: September 2023

In this article I attempt to approach haptotherapy – and haptonomy in general – from the perspective of empathy. At first sight, here seems to be striking relationships between haptotherapy and empathy. From an empathy perspective, haptotherapy is like empathy-with-the-hands, whereas empathy could be called haptotherapy-with-your-feelers. Both have a supportive, affirmative effect. Both are beneficial but also risky. For both it is important to stay in touch with your own feelings while being in contact with the other person, the client. In haptotherapy practice, the two often go together. Being myself a non-haptotherapist, I will focus on empathyin in this article. I will present the outline of a theory that gives insight into both the supportive effects of empathy as well as it’s dangerous aspects. I will provide the reader with sufficient points of contact to be able to make the connection to haptotherapy.
Estimating Household Price and Income Elasticities for Animal-Sourced Food: The Case of Bengkulu Province, Indonesia
Authors: Khoiriyah Nikmatul , Forgenie David , Iriany Atiek
Published: September 2023

Bengkulu is one of the provinces in Indonesia where household protein consumption is still below the national protein recommended allowance. This paper examines the effect of price, income and socio-demographic factors on household demand using the Quadratic Almost Ideal Demand System (QUAIDS) model and data from the Indonesian National Socio-Economic Survey (Susenas) in March 2021, which includes 5,079 households. The QUADS parameters were estimated using the Iterated Nonlinear Seemingly Unrelated Regression technique with theoretical restrictions imposed. The estimated parameters from the model were utilized to derive price and income elasticities for animal-derived foods. Empirically, it was found that fish is the most elastic animal-sourced food with a demand elasticity of 4.44%, followed by beef (2.78%), milk (1.94%), poultry (1.54%), and eggs (0.82%). Fish substitutes for beef, chicken, and eggs when prices increase but is complementary to milk. Four animal-sourced food groups, namely fish, beef, milk, and poultry, are luxury items, with income elasticities of 2.57%, 2.39%, 2.22%, and 1.36%, respectively. In contrast, eggs were found to be a normal good with an income elasticity of 0.53%. Fish and beef are very elastic; thus, the government can use pricing strategies and implement policy to increase poultry and eggs production so that daily protein requirements of 57 grams per capita per day are reached in Bengkulu province.
An antagonism between Spinophilin and Syd-1 operates upstream of memory-promoting presynaptic long-term plasticity
Authors: Ramesh Niraja , Escher Marc , Turrel Oriane , Lützkendorf Janine , Matkovic Tanja , Liu Fan , Sigrist Stephan J
Published: September 2023

We still face fundamental gaps in understanding how molecular plastic changes of synapses intersect with circuit operation to define behavioral states. Here, we show that an antagonism between two conserved regulatory proteins, Spinophilin (Spn) and Syd-1, controls presynaptic long-term plasticity and the maintenance of olfactory memories in Drosophila. While Spn mutants could not trigger nanoscopic active zone remodeling under homeostatic challenge and failed to stably potentiate neurotransmitter release, concomitant reduction of Syd-1 rescued all these deficits. The Spn/Syd-1 antagonism converged on active zone close F-actin, and genetic or acute pharmacological depolymerization of F-actin rescued the Spn deficits by allowing access to synaptic vesicle release sites. Within the intrinsic mushroom body neurons, the Spn/Syd-1 antagonism specifically controlled olfactory memory stabilization but not initial learning. Thus, this evolutionarily conserved protein complex controls behaviorally relevant presynaptic long-term plasticity, also observed in the mammalian brain but still enigmatic concerning its molecular mechanisms and behavioral relevance.
Immunoglobulin M regulates airway hyperresponsiveness independent of T helper 2 allergic inflammation
Authors: Hadebe Sabelo , Savulescu Anca Flavia , Khumalo Jermaine , Jones Katelyn , Mangali Sandisiwe , Mthembu Nontobeko , Musaigwa Fungai , Maepa Welcome , Ndlovu Hlumani , Ngomti Amkele , Scibiorek Martyna , Okendo Javan , Brombacher Frank
Published: September 2023

Allergic asthma is a disease driven by T helper 2 (Th2) cells, eosinophilia, airway hyperresponsiveness (AHR) and IgE-secreting B cells. Asthma is largely controlled by corticosteroids and ý2 adregenic receptor agonists that target and relax airway smooth muscle (ASM). Immunoglobulin M (IgM) isotype secreted by naïve B cells is important for class switching but may have other undefined functions.We investigated the role of IgM in a house dust mite (HDM)-induced Th2 allergic asthma model. We sensitised wild-type (WT) and IgM-deficient (IgM
-/-
) mice with HDM and measured AHR, and Th2 responses. We performed RNA sequencing on the whole lung of WT and IgM
-/-
mice sensitised to saline or HDM. We validated our AHR data on human ASM by deleting genes using CRISPR and measuring contraction by single-cell force cytometry.We found IgM to be essential in AHR but not Th2 airway inflammation or eosinophilia. RNA sequencing of lung tissue suggested that IgM regulated AHR through modulating brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (
Baiap2l1
) and other genes. Deletion of
BAIAP2L1
led to a differential reduction in human ASM contraction when stimulated with TNF-α and Acetylcholine, but not IL-13.These findings have implications for future treatment of asthma beyond current therapies.
Natural differential privacy—a perspective on protection guarantees
Authors: Altman Micah , Cohen Aloni
Published: September 2023

We introduce “Natural” differential privacy (NDP)—which utilizes features of existing hardware architecture to implement differentially private computations. We show that NDP both guarantees strong bounds on privacy loss and constitutes a practical exception to no-free-lunch theorems on privacy. We describe how NDP can be efficiently implemented and how it aligns with recognized privacy principles and frameworks. We discuss the importance of formal protection guarantees and the relationship between formal and substantive protections.
Asociación entre bienestar psicológico y adherencia a dieta mediterránea en pacientes chilenos con síndrome metabólico
Authors:   , Mateo Hernández Camila
Published: September 2023

Un estilo de vida mediterráneo abarca aspectos físicos, psicológicos y sociales. La dieta mediterránea ha demostrado evidencia sustancial sobre sus beneficios cardiometabólicos, pero cuenta con pocos estudios de calidad que integren al bienestar psicológico en su evaluación y análisis. Por otra parte, existe evidencia que relaciona la promoción de estados psicológicos positivos a una mayor adherencia a comportamientos de estilo de vida saludables. En base a esto, la hipótesis de este proyecto postula que aquellos individuos con mayor bienestar psicológico tendrán mayor adherencia a dieta mediterránea, y viceversa. Esta propuesta se enmarca en el proyecto ChileMed, investigación que estudia la relación sinérgica entre una intervención nutricional basada en dieta mediterránea y una intervención psicológica centrada en el bienestar, sobre la prevención de enfermedades crónicas en pacientes chilenos con síndrome metabólico. Como objetivo principal, se buscó determinar si existe una asociación basal entre los niveles de bienestar psicológico y adherencia a dieta mediterránea en pacientes chilenos con síndrome metabólico; y como objetivo secundario, determinar si posterior a la intervención en bienestar psicológico se logra aumentar la adherencia a dieta mediterránea a mediano plazo (6 meses) en estos individuos. Se utilizaron datos de aquellos participantes reclutados desde agosto de 2021 hasta septiembre de 2022 al inicio del estudio y secundariamente a un subgrupo con seguimiento a 6 meses de las intervenciones. Para medir el bienestar psicológico, se utilizaron las escalas de Ryff y para medir adherencia a dieta mediterránea se aplicó el índice chileno de dieta mediterránea. Para el análisis estadístico, se realizaron regresiones lineales y comparaciones mediante ANOVA de dos vías con medidas repetidas. Como resultado, se obtuvo una asociación positiva leve entre bienestar psicológico y adherencia a dieta mediterránea a nivel basal, perdió significancia estadística después de corregir por la edad. Tras el período de seguimiento a 6 meses del inicio de la intervención, se observó una tendencia a mayor adherencia al patrón de alimentación mediterráneo en el grupo manejado con dieta mediterránea más bienestar versus la intervención nutricional aislada, pero se requiere un mayor tamaño muestral para alcanzar la significancia estadística. En conclusión, es relevante continuar investigando el rol del bienestar sobre los cambios de estilo de vida como potencial punto de apoyo en la prevención de enfermedades crónicas.
Disciplinas tecnológicas evidenciadas nas matrizes curriculares do curso de contabilidade de IES do Ceará
Authors: Maia Anna Beatriz Grangeiro Ribeiro , Siebra Alexandra Alencar , Batista Nicoly Ribeiro , Lima Felipe Derick de Sousa
Published: September 2023

O presente estudo tem como objetivo evidenciar em que extensão, no tocante ao ensino, as matrizes curriculares de ciências contábeis das instituições de ensino superior do Ceará contemplam a tecnologia da informação em suas disciplinas. Para tanto, realiza-se pesquisa bibliográfica e documental, com abordagem qualiquantitativa, de propósito descritivo, tendo como objeto de estudo as matrizes curriculares das instituições de ensino superior. Os resultados obtidos demonstram que apesar de 90% das IES analisadas possuírem alguma disciplina com aplicação tecnológica a maioria das disciplinas que compõem as matrizes curriculares não possuem abordagem que envolva a tecnologia da informação. Das 412 disciplinas analisadas apenas 4,85% envolvem tecnologia, demonstrando assim que o curso em sua generalidade não utiliza metodologias modernas para a transmissão de conhecimento, pois emprega uma abordagem envolvendo mais teoria do que prática. Além disso, a constante atualização tecnológica que está atrelada ao mercado de trabalho deixa de fazer parte do cotidiano do acadêmico por consequência da ausência de metodologias práticas. Destarte, esta pesquisa contribui com às discussões nas IES relacionadas a implementação de disciplinas voltadas para a era digital, no que tange à capacitação dos futuros profissionais contábeis para as mudanças tecnológicas.
HAIR REJUVENATION THROUGH AYURVEDA: A REVIEW
Authors: Sahu Geetanjali
Published: September 2023

Ayurveda is the science which places more emphasis on the prevention of disease and maintenance of health rather than simply treating it. This is achieved by following a strict pathya-apathya. Nowadays, the most common factors inducing hair fall include stress, major illnesses, medication use, depression, family history, autoimmune disease, hormonal imbalance, nutritional deficiencies, etc. Approximately 50% of Indians are losing hair faster than ever, and the current beauty industry has destroyed hair quality with poor-quality hair products. As hair fall is a complex problem, Ayurveda believes it’s the effect of internal imbalances. Ayurveda has shown promising results in preventing hair fall and regrowth through herbal products and lifestyle modification. It has been observed that many herbs and their extracts have proven good results in such cases. For this article, we have compiled and critically analyzed the ayurvedic concept of nidana and chikitsa mentioned in different classics for this alarming condition.
FAMÍLIA MULTIESPÉCIE
Authors: Ferreira de Oliveira Teresa Cristina , Santana Oliveira Luiza
Published: September 2023

Os animais deixaram de ser considerados como objetos de posse com função de servir aos seus “donos” como auxiliares nas tarefas de trabalho, guardadores da integridade física e da propriedade, e, atualmente, passaram a ocupar lugar de membros das famílias multiespécie com status afetivo de igual valor aos humanos. Este estudo aborda o tema Família Multiespécie: aspecto jurídico da guarda compartilhada dos animais de estimação, após dissolução do casamento ou da união estável e tem como objetivo verificar de que forma se configura a guarda compartilhada desses seres não-humanos durante os processos de dissolução dos laços conjugais. Apesar da legislação ainda não ter sido adequada a situações dessa natureza, isso não impede que esses animais de estimação sejam alvo de disputas judiciais.  Foi feito um levantamento bibliográfico sobre o assunto em questão com análise de teses, dissertações, artigos científicos e estudo de jurisprudências que envolveram casos de disputa por esses animais e os resultados confirmaram que as decisões dos magistrados têm sido pautadas na analogia ao direito de família, considerando o bem-estar de todos os envolvidos nos processos, inclusive os animais que, deixam de ser considerados como bens semoventes, passando ao status de membro dessa nova configuração familiar.
Structural view on autophagosome formation
Authors: Noda Nobuo N.
Published: September 2023

Autophagy is a conserved intracellular degradation system in eukaryotes, involving the sequestration of degradation targets into autophagosomes, which are subsequently delivered to lysosomes (or vacuoles in yeasts and plants) for degradation. In budding yeast, starvation‐induced autophagosome formation relies on approximately 20 core Atg proteins, grouped into six functional categories: the Atg1/ULK complex, the phosphatidylinositol‐3 kinase complex, the Atg9 transmembrane protein, the Atg2–Atg18/WIPI complex, the Atg8 lipidation system, and the Atg12–Atg5 conjugation system. Additionally, selective autophagy requires cargo receptors and other factors, including a fission factor, for specific sequestration. This review covers the 30‐year history of structural studies on core Atg proteins and factors involved in selective autophagy, examining X‐ray crystallography, NMR, and cryo‐EM techniques. The molecular mechanisms of autophagy are explored based on protein structures, and future directions in the structural biology of autophagy are discussed, considering the advancements in the era of AlphaFold.
Gaiellaceae
Authors: Albuquerque Luciana , Egas Conceição
Published: September 2023

Ga.i.el.la.ce'a.e. N.L. fem. dim. n.
Gaiella
, type genus of the family; L. fem. pl. n. suff. –
aceae
, ending to denote a family; N.L. fem. pl. n.
Gaiellaceae
, the
Gaiella
family.

Actinomycetota / Thermoleophilia / Gaiellales / Gaiellaceae

The family
Gaiellaceae
is a member of the order
Gaiellales
. This family accommodates one genus,
Gaiella
, composed of one validly published species named
Gaiella occulta
. Cells stain Gram‐negative and form rod‐shaped cells. Endospores are not observed. The organisms are mesophilic, strictly aerobic, and chemoorganotrophic. The peptidoglycan contains
meso
‐diaminopimelic acid (
meso
‐Dpm) as diagnostic diamino acid and is of type A1γ'. The major respiratory quinone is menaquinone 7 (MK‐7). The polar lipid profile consists of unidentified phospholipids and unidentified phosphoglycolipids. Members of the family
Gaiellaceae
possess internally methyl‐branched fatty acids, namely iso‐C
17:0
10‐methyl, iso‐C
15:0
8‐methyl, and iso‐C
16:0
10‐methyl. 16S rRNA gene sequence signature nucleotides that differentiate the family
Gaiellaceae
from any other family within the class
Thermoleophilia
are nucleotide positions 63:104 (C–G), 70:98 (A–G), 139:224 (C–G), 145:177 (U–G), 377:386 (G–C), 590:649 (G–C), 600:638 (G–C), and 722:733 (U–G). The species
Gaiella occulta
was isolated from a deep aquifer.

DNA G + C content (mol%)
: 71.6 (HPLC).

DNA G + C content (%)
: 71.7 (genome).

Type genus
:
Gaiella
Albuquerque et al. 2011, VL144.
Tichowtungiales
Authors: Mu Da‐Shuai , Du Zong‐Jun
Published: September 2023

Ti.chow.tung.i.a'les. N.L. fem. n.
Tichowtungia,
type genus of the order; L. fem. pl. n. suff. ‐
ales
, ending to denote an order; N.L. fem. pl. n.
Tichowtungiales,
order of the genus
Tichowtungia
.

Verrucomicrobiota / Tichowtungiia / Tichowtungiales

Currently,
Tichowtongiales
contains the families
Tichowtongiaceae
and
Pontiellaceae
and a total of three cultivable strains, namely
Tichowtungia aerotolerans
S‐5007
T
,
Pontiella desulfatans
F1
T
, and
Pontiella sulftirelatans
F21
T
. Phylogenetic analyses based on 16S rRNA genes and genomes indicated that
Tichowtungiales
branched within the radiation of the group
Kiritimatiellia
. The order
Tichowtungiales
are Gram‐stain‐negative, anaerobic, nonmotile, non‐spore‐forming, and coccus‐shaped. Cells grow poorly under low oxygen conditions. Respiratory lipoquinones are not formed during anaerobic cultivation in
T. aerotolerans
S‐5007
T
. However, the respiratory quinones in strains
P. desulfatans
F1
T
and
P. sulftirelatans
F21
T
include MK‐6, MK‐7, MK‐8, and MK‐9. The major cellular fatty acids are C
18:0
, iso‐C
12:0
, iso‐C
14:0
, iso‐C
16:0
, and iso‐C
18:0
.

DNA G + C content (mol%)
:
53.1–56.0.

Type genus
:
Tichowtungia
Mu et al. 2020.
Enhanced Magnetic Anisotropy for Reprogrammable High‐Force‐Density Microactuators
Authors: Chen Yulan , Srinivasan Karthik , Choates Marcus , Cestarollo Ludovico , El‐Ghazaly Amal
Published: September 2023

The precise control of magnetic properties at the microscale has transformative potential in healthcare and human‐robot interaction. This research focuses on understanding the magnetic interactions in nanostructure assemblies responsible for microactuation. By combining experimental measurements and micromagnetic simulations, the interactions in both nanocube and nanochain assemblies are elucidated. Hysteresis measurements and first‐order reversal curves (FORC) reveal that the spatial arrangement of these assemblies governs their collective magnetism. A critical concentration threshold is observed where a transition from ferromagnetic‐like to antiferromagnetic‐like coupling occurs. Leveraging the high uniaxial anisotropy of 1D nanochains, the remanent magnetization of assembled chain structures is maximized for efficient magneto‐mechanical energy transduction. By utilizing an optimized magnetic nanostructure concentration, a flexible film is fabricated, and its significantly enhanced mechanical deformation response to a small magnetic field, surpassing conventional particle‐based samples by a factor of five, is demonstrated. Demonstrating excellent transduction efficiency, visible deformations such as bending and S‐shaped twisting modes are achieved with an applied field of less than 400 Oe. Furthermore, the reprogrammability of the actuator, achieving a U‐shaped bending mode by altering its magnetization profile, is showcased. This research provides valuable insights for designing reconfigurable and effective microactuators and devices at significantly smaller scales than previously possible.
Three‐Step Regenerative Strategy: Multifunctional Bilayer Hydrogel for Combined Photothermal/Photodynamic Therapy to Promote Drug‐Resistant Bacteria‐Infected Wound Healing
Authors: Zha Kangkang , Zhang Wenqian , Hu Weixian , Tan Meijun , Zhang Shengming , Yu Yongsheng , Gou Shuangquan , Bu Pengzhen , Zhou Bikun , Zou Yanan , Xiong Yuan , Mi Bobin , Liu Guohui , Feng Qian , Cai Kaiyong
Published: September 2023

The drug‐resistant bacterial‐infected skin wound is still a severe healthcare problem. Uncontrolled bacterial infection, abundant reactive oxygen species (ROS) content, and prolonged inflammatory response are detrimental to wound healing. Moreover, excessive vessel growth can result in unsatisfactory scar formation. Herein, a three‐step regenerative strategy based on a bilayered gelatin/acryloyl β‐cyclodextrin (BGACD) hydrogel containing physical host–guest complexations and chemical crosslinks is proposed. The hydrogel is loaded with humic acids (HAs) and astragaloside IV (AS) in the lower layer and verteporfin (Vt) in the upper layer. Different gelatin/acryloyl β‐cyclodextrin ratios endow the lower and upper layers of the hydrogel with different degradation rates. Under light irradiation, the combination of HAs‐induced photothermal therapy (PTT) and verteporfin‐induced photodynamic therapy effectively inhibits MRSA growth. The HAs and astragaloside IV are released from the lower layer to scavenge ROS and promote M2 macrophage polarization and angiogenesis during the inflammation and early proliferation phases, while verteporfin releases from the upper layer suppress excessive vessel growth during the late proliferation and remodeling phases. The HAs‐AS@Vt@BGACD hydrogel successfully achieves rapid and scarless wound healing in an MRSA‐infected wound model in rats. Therefore, the HAs‐AS@Vt@BGACD hydrogel shows promising potential for the treatment of drug‐resistant bacteria‐infected skin wound healing.
High‐Performance Filterless Blue Narrowband Organic Photodetectors
Authors: Zhang Tianyi , Winkler Louis Conrad , Wolansky Jakob , Schröder Jonas , Leo Karl , Benduhn Johannes
Published: September 2023

Modern image sensors necessitate three color‐selective photodetectors: red, green, and blue (RGB) sensing units. Among those, blue light‐specific photodetectors are comparably much less reported. Here, a fully thermal‐evaporated organic photodetector (OPD) with narrowband blue detection based on exploring the dual role of the hole‐transporting layer is elegantly demonstrated. By incorporating a MoO3‐doped underlayer, the narrowband OPD achieves high external quantum efficiency up to 50% at 0 V with thin‐film devices. By adopting an intrinsic underlayer in planar junction configuration along with efficient hole and electron blocking layers, an ultralow dark current (2.46 × 10−12 A cm−2 at −0.1 V) is achieved. The device has a calculated specific detectivity (D*) reaching a record‐high value of 6.35 × 1014 Jones, outperforming commercial silicon photodetectors, and an ultrahigh linear dynamic range of 205 dB. This work paves the way for high‐sensitivity narrowband organic photodetectors in the visible spectral region.
Wafer‐Scale Memristor Array Based on Aligned Grain Boundaries of 2D Molybdenum Ditelluride for Application to Artificial Synapses
Authors: Yang Jihoon , Yoon Aram , Lee Donghyun , Song Seunguk , Jung IL John , Lim Dong‐Hyeok , Jeong Hongsik , Lee Zonghoon , Lanza Mario , Kwon Soon‐Yong
Published: September 2023

2D materials have attracted attention in the field of neuromorphic computing applications, demonstrating the potential for their use in low‐power synaptic devices at the atomic scale. However, synthetic 2D materials contain randomly distributed intrinsic defects and exhibit a stochasitc forming process, which results in variability of switching voltages, times, and stat resistances, as well as poor synaptic plasticity. Here, this work reports the wafer‐scale synthesis of highly polycrystalline semiconducting 2H‐phase molybdenum ditelluride (2H‐MoTe2) and its use for fabricating crossbar arrays of memristors. The 2H‐MoTe2 films contain small grains (≈30 nm) separated by vertically aligned grain boundaries (GBs). These aligned GBs provide confined diffusion paths for metal ions filtration (from the electrodes), resulting in reliable resistive switching (RS) due to conductive filament confinement. As a result, the polycrystalline 2H‐MoTe2 memristors shows improvement in the RS uniformity and stable multilevel resistance states, small cycle‐to‐cycle variation (<8.3%), high yield (>83.7%), and long retention times (>104 s). Finally, 2H‐MoTe2 memristors show linear analog synaptic plasticity under more than 2500 repeatable pulses and a simulation‐based learning accuracy of 96.05% for image classification, which is the first analog synapse behavior reported for 2D MoTe2 based memristors.
Microphysiological Modeling of Gingival Tissues and Host‐Material Interactions Using Gingiva‐on‐Chip
Authors: Muniraj Giridharan , Tan Rachel Hui Shuen , Dai Yichen , Wu Ruige , Alberti Massimo , Sriram Gopu
Published: September 2023

Gingiva plays a crucial barrier role at the interface of teeth, tooth‐supporting structures, microbiome, and external agents. To mimic this complex microenvironment, an in vitro microphysiological platform and biofabricated full‐thickness gingival equivalents (gingiva‐on‐chip) within a vertically stacked microfluidic device is developed. This design allowed long‐term and air‐liquid interface culture, and host‐material interactions under flow conditions. Compared to static cultures, dynamic cultures on‐chip enabled the biofabrication of gingival equivalents with stable mucosal matrix, improved epithelial morphogenesis, and barrier features. Additionally, a diseased state with disrupted barrier function representative of gingival/oral mucosal ulcers is modeled. The apical flow feature is utilized to emulate the mechanical action of mouth rinse and integrate the assessment of host‐material interactions and transmucosal permeation of oral‐care formulations in both healthy and diseased states. Although the gingiva‐on‐chip cultures have thicker and more mature epithelium, the flow of oral‐care formulations induced increased tissue disruption and cytotoxic features compared to static conditions. The realistic emulation of mouth rinsing action facilitated a more physiological assessment of mucosal irritation potential. Overall, this microphysiological system enables biofabrication of human gingiva equivalents in intact and ulcerated states, providing a miniaturized and integrated platform for downstream host‐material and host‐microbiome applications in gingival and oral mucosa research.