bluuebunny/crossref_metadata_2025 huggingface dataset:
Investigation of the effect of curcumin on oxidative stress, local inflammatory response, COX-2 expression, and microvessel density in Trichinella spiralis induced enteritis, myositis and myocarditis in mice
Authors: Hamed A. M. R. , Abdel-Shafi I. R. , Elsayed M. D. A. , Mahfoz A. M. , Tawfeek S. E. , Abdeltawab M. S. A.
Published: May 2022

Background

Curcumin exerts anti-oxidant and anti-inflammatory properties that have proven to be of value in the management of several parasitic infections.

Objective

Investigation of the value of curcumin in the management of trichinosis either alone or as an adjuvant to albendazole.

Methods

Animals received either curcumin 150 mg/kg, curcumin 300 mg/kg, albendazole 50 mg/ kg or combined curcumin 150mg/kg and albendazole 50 mg/kg and were compared with control infected and non-infected mice. Estimation of intestinal and muscular parasitic load and blood malondialdehyde level, in addition to the histopathological examination of small intestine, skeletal muscle tissue and heart was performed. Also, assessment of the local expression of cyclooxygenase-2 enzyme (COX-2) and CD34 in these samples was done by immunohistochemistry.

Results

Curcumin was found efficient in reducing parasitic load. It also lowered serum MDA level, local COX-2 and CD34 expression. An evident anti-inflammatory effect of curcumin was observed in intestinal, skeletal muscle and cardiac muscle histopathological sections.

Conclusion

The anti-inflammatory, anti-oxidant and anti-angiogenic effects of curcumin can help to improve trichinellosis-induced pathology. Curcumin can therefore be of value as an adjuvant therapy to conventional antiparasitic agents and can also produce promising results when used alone at higher doses.
The prevalence of intestinal parasite infections in goats from smallholder farms in Northern Thailand
Authors: Wuthijaree K. , Tatsapong P. , Lambertz C.
Published: May 2022

The present study determined the prevalence of gastrointestinal (GI) parasites in small ruminants kept in smallholder farms in Phitsanulok, Northern Thailand. A total of 885 goats from 31 smallholder farms were selected randomly between May 2019 to January 2020. Fecal samples were collected to estimate fecal egg counts and oocysts counts using the modified McMaster technique. Furthermore, pooled fecal samples from each of the farms were cultured in order to differentiate third-stage larvae of nematode. Examination of fecal samples revealed that 885 were positive for one or more parasites, giving an overall prevalence of 87.2 %, of which 38.6 % were infected with one and 48.6 % with multiple parasite. Strongyles and Eimeria oocysts were the most prevalent. Haemonchus contortus and Strongyloides papillosus were the predominant species based on the percentage of larvae in fecal cultures. Tapeworm eggs were encountered in 14.2 % of all samples. No significant difference in gastrointestinal parasite prevalence was associated with sex of the host. Infection was significantly (P = 0.009) highest in poor body conditioned goats (72.0 %) as compared to moderate (48.9 %) and good body conditioned (50.0 %) goats. This report on prevalence of GI parasites of small ruminants in smallholder farms in Northern Thailand reveals a high endoparasitic infections that appeared well-adapted to environmental conditions. Further studies on endoparasite control are required to establish the impact of parasitism on productive performance, including monitoring control parasite programs are needed for better health and productivity.
Knowledge Gaps Between Canadian Public Policy and Religious Actors; a New Hurdle for Women in Agunah
Authors: Stein Talya
Published: May 2022

Knowledge Gaps Between Canadian Public Policy and Religious Actors; a New Hurdle for Women in Agunah
This research paper seeks to highlight the harmful social consequences that arise when there are knowledge gaps in Canadian public policy in religious affairs. In order to safeguard the wellbeing of Canadians of faith, Canadian policy makers and adjudicators should operate with a working knowledge of its religious populations and consult religious actors on relevant issues. I will use the Jewish divorce phenomenon, known as agunah, the spiritual chaining of spouses, to illustrate the social consequences that arise once public policy overlooks religious affairs. The kinds of knowledge gaps in Canadian public policy that enables circumstances like agunot, worsens human right’s abuses (Greenberg-Kobrin 1999), and religious and community alienation and the weakening of Canadian institutions (“Bruker v. Marcovitz.”)
 
I will first provide a brief explanation of the agunah phenomenon in order to capture the severity of the religious, as well as spiritual, consequences a refused Jewish divorce leaves in its wake. After an understanding of agunah has been established, I will deconstruct Section 21.2 of the Divorce Act (1990) and exemplify how a situation of agunah could occur by the manipulation of the provision in order to remove barrier to divorce. Lastly, I will employ the 1969 case of “Bruker vs. Markovitz” to explore the instances in which such knowledge gaps weaken Canadian institutions.
 
Though steps have been made by Canadian policy makers and judicial figures in the past to prevent the proliferation of agunah abuse cases, there still lacks sufficient precedent or literature available. This egregious oversight of public policy leaves vulnerable people of faith, most commonly women, to grapple with legal incongruences and spiritual harm alone. An active effort to grasp religious law and legal nuances by public policy makers must be made in order to mitigate social maladies and protect all populations, including the religious populations, of Canada.
Batman as Modern Revenge Tragedy: The Shakespearean Dark Knight
Authors: Green Daniel
Published: May 2022

Batman as Modern Revenge Tragedy: The Shakespearean Dark Knight
Both Bob Kane’s Batman and Shakespeare’s Hamlet, lose parents, dress in black, put on antic dispositions, and go on personally motivated, violent missions for justice and revenge. The characters enter what seems to be an infinite mourning, where their innately flawed visions of obtaining justice are paired with unstoppable determinations. With my presentation, I intend on using video to demonstrate the historical trends of the revenge tragedy genre, and analyze their potential connection to the comic book medium, especially Batman. Using video, I can explore “adaptation” and all its nuances by implementing costume and visuals that mirror both the bard and the bat. Comics like The Dark Knight Returns (1986) and feature films like Batman V Superman, The Dark Knight Trilogy, and other Batman films act, in my view, as modern revenge tragedies; perhaps “Batman” becoming the entity that it is today has something to do with a legendary play, Hamlet, or at the very least, the legendary renaissance drama theatrics that might be hidden within it. Additionally, in light of Coen’s latest film, The Tragedy of Macbeth (2021), and Reeves’s The Batman (2022) release around the corner, themes of darkness, “dark knights,” and revenge continue to rivet contemporary consumers of the theatric and the cinematic.
Examining the Imagery of Kajillionaire
Authors: Adamson Emily
Published: May 2022

Examining the Imagery of Kajillionaire
For FILM 456: The Video Essay, as taught by Dan Simpson, I wrote and produced a video essay detailing my analysis of one particular scene in Kajillionaire (2020), dir. Miranda July. In using multiple aspects of cinematic language, the evening scene early on in the film provides subtextual evidence detailing the emotional abuse and neglect inflicted on the main character, Old Dolio, by her parents. The mise-en-scène of an office cubicle separates her physically from her parents’ domestic sleeping area, as well as visually playing on their smalltime heists consuming their whole lives. The dialogue within the scene reveals her parents’ simultaneous infantilization and dismissal of her and her ideas. And the lighting design represents her sheltered and fearful relationship to the outside world, thanks to her parents' opinions and lifestyle.
Transforming the Bildungsroman to Develop Consciousness About Race
Authors: Maidment Grace
Published: May 2022

Toni Morrison’s The Bluest Eye is unique in its position within the ​genre of the Bildungsroman. The Bildungsroman typically ​examines factors that dictate its protagonist’s psychosocial growth on their journey toward self-realization and acceptance of their place in the world. Morrison, on the contrary, demonstrates how the idealization of whiteness and the racial self-loathing it engenders makes it impossible for a young, Black, female protagonist, like Pecola, to exercise narrative authority or progress toward self-realization and social acceptance. My paper contrasts a "classic" Bildungsroman featuring a young, white, male protagonist, such as James Joyce's "Araby", with the split narrative voice and reversed narrative progression in ​The Bluest Eye. Morrison recounts Pecola's story from the perspective of her friend, Claudia, rather than as Pecola's stream of consciousness. She also challenges key plot-related elements, such as the moment of resolution. My aim is to show how Morrison does not merely substitute a young, white, male protagonist with a young, Black, female protagonist to produce a realistic account of Black female experience. Instead, she manipulates the generic conventions of the Bildungsroman to show how both the world and the narratives that tell stories about the world fail Pecola, and, by extension, Claudia. How we tell stories matters as much as whose stories we tell. The world Morrison presents through her alteration of the Bildungsroman forces the reader to question the static ideals in the world around them and reflect on the role of race in the development of agency over one’s own story.
Going Steady; What Did It Look Like To Go From Single To Married in Renaissance Italy
Authors: Gibson Isobel
Published: May 2022

My research focuses on what it looked like to find love in Renaissance Italy. This paper is chiefly concerned with the stages of courtship and engagement leading to marriage in early modern Italy for the purpose of understanding such an intimate, consequential, and complex experience that reveals the multitude and stratification of experiences within Italy. Currently missing from the scholarship is a synthesized presentation of the development from single-hood to courtship to marriage and married life, and sometimes annulment or divorce. I will draw on a variety of primary and secondary sources across the socio-economic spectrum to illustrate what ‘dating’, engagements, weddings, and married life looked like across Early Modern Italy. This paper presents a comprehensive and linear account of what an individual's experience was on the path to heterosexual marriage, beginning with how couples met each other and what the initial stage of flirting and courtship looked like. In order to best interpret the findings, I have used an interdisciplinary approach in order to better understand the complexities of the topic that are, like much of social history, often reluctant to reveal themselves to historians.
An Audio-Visual Prophecy: Arcane - The Prestigious Concert Scene
Authors: Zhang Le
Published: May 2022

An Audio-Visual Prophecy: Arcane - The Prestigious Concert Scene 
The topic of my video essay is to take a close examination on the prestigious concert scene on Arcane: League of Legends. To see how the use of the mise-en-scene and audio-visual language helps to make foreshadowing on characters’ behaviors. The video essay illustrates the changing psychological states of several main characters (Jess, Mel, Hemerdinger and several councilors) based on their lines and action details. Through the analysis of cinematic elements like mise-en-scene, background music, lighting and staging provide in-depth observations and analysis of how the film uses superb audio-visual language to foreshadow the actions and situations of different characters later in the story. I also added tons of arrows and circles to highlight the significant elements in each frame to cooperate with my voiceover and helps focusing audiences’ attentions as well. Prof. Daniel in FILM 456 The Video Essay provided me a lot of advice, especially about the copyright issue about the editing of background music after the video was uploaded to the public platform. Some of the points Prof. Daniel mentioned in the lecture also helped me to better plan the structure and framework of the whole video.
Two new species of the genus Hellinsia Tuff, 1905 (Lepidoptera: Pterophoridae) from South Africa
Authors:   Moscow Region Odintsovsky District, Moscow, 143039, Russia, Kovtunovich V.N. , Ustjuzhanin P.Ya. ,   Altai State University, Lenina 61, Barnaul, 656049, Russia,   Biological Institute, Tomsk State University, Lenina Prospekt 36, Tomsk, 634050, Russia, Pototski A.N. ,   Estonian Society of Lepidopterologists, Lasnamäe Gymnasium, Pae 59, 13621, Tallinn, Estonia, Streltzov A.N. ,   Herzen State Pedagogical University, Moika Emb. 4., St. Petersburg, 191186, Russia
Published: May 2022

. Two new species, Hellinsia karinupponeni Kovtunovich, Ustjuzhanin et Pototski, sp. n. and Hellinsia ristoi Kovtunovich, Ustjuzhanin et Pototski, sp. n., are described from the Northern Cape and Western Cape provinces of the Republic of South Africa, respectively. Holotypes of both species are deposited in the Estonian University of Life Sciences, Tartu.
Decidability of SHIQ with Complex Role Inclusion Axioms
Authors: Horrocks Ian , Sattler Ulrike
Published: May 2022

Motivated by medical terminology applications, we investigate the decidability of an expressive and prominent DL, SHIQ, extended with role inclusion axioms of the form RoS⊑T. It is well-known that a naive such extension leads to undecidability, and thus we restrict our attention to axioms of the form RoS⊑R or SoR⊑R, which is the most important form of axioms in the applications that motivated this extension. Surprisingly, this extension is still undecidable. However, it turns out that restricting our attention further to acyclic sets of such axioms, we regain decidability. We present a tableau-based decision procedure for this DL and report on its implementation, which behaves well in practise and provides important additional functionality in a medical terminology application.
Least common subsumers, most specific concepts, and role-value-maps in a description logic with existential restrictions and terminological cycles
Authors:   Theoretical Computer Science Dresden University of Technology, Baader Franz
Published: May 2022

In a previous report we have investigates subsumption in the presence of terminological cycles for the description logic EL, which allows conjunctions, existential restrictions, and the top concept, and have shown that the subsumption problem remains polynomial for all three types of semantics usually considered for cyclic definitions in description logics. This result depends on a characterization of subsumption through the existence of certain simulation relations on the graph associated with a terminology. In the present report we will use this characterization to show how the most specific concept and the least common subsumer can be computed in EL with cyclic definitions. In addition, we show that subsumption in EL (with or without cyclic definitions) remains polynomial even if one adds a certain restricted form of global role-value-maps to EL. In particular, this kind of role-value-maps can express transitivity of roles.
Impact of E-retailing Ethics on Consumer Repurchase Intention
Authors: Ghias Saqib , Ahmed Kazi Afaq , Khan Azam Anwar
Published: May 2022

Purpose: Online retailing has grown tremendously over the last decade, particularly in the COVID 19 period but little attention has been given to ethical problems arising from it. The purpose of this study is to investigate the impact of e-retailing ethics on consumer repurchase intention aiming to highlight the significance of ethical consideration in e-retailing business..  

Design/Methodology/Approach: This is a quantitative study and the sample size is 212 participants. Male participants were 129 and  Female participants were  83. Respondents mainly included consumers with varying frequencies of online purchasing. The conceptual framework comprised of reliability, non-deception, security, trust and e-service quality as independent variables moderated by shopping habits. The dependent variable was repurchase intention. PlS-SEM was used to analyze the data. The participants mostly were residents of Karachi.

Findings: The repurchase intention of consumers is directly impacted by three independent variables of e-retailing ethics out of five tested in the study i.e. E-service quality, reliability and non-deception while remaining variables trust and security proved insignificant. The study results further revealed that reliability, non-deception, and e-service quality are also positively moderated by shoping habits while security and trust proved insignificant.

Implications/Originality/Value: The findings can be used by online retailing outlets to design marketing strategies for successfully running their store.
Analisis Cost of Poor Quality Proses Painting Produk Pan Oil TD
Authors: Casban Casban , Zulfikar Shodiq Rahma
Published: May 2022

Proses painting pembuatan produk pain oil TD banyak mengalami cacat, sehingga diperlukan pengerjaan ulang dengan melakukan repainting untuk memperbaiki cacat dan ketidaksesuaian kualitas produk. Untuk mengurangi kerugian perusahaan, maka perlu melakukan evaluasi biaya perbaikan kualitas dalam tahapan proses produksi. Tujuan penelitian adalah menghitung cost of poor quality (COPQ) dan menentukan peta kendali kualitas produk pan oil TD dalam proses painting. Desain penelitian deskriptif eksploratif untuk menggambarkan pengendalian kualitas yang berhubungan dengan proses painting. Pendekatan penelitian adalah kualitatif dan kuantitatif untuk menjelaskan cacat yang terjadi dalam proses painting secara keseluruhan dan melakukan perhitungan biaya repair, biaya scrap dan COPQ. Perhitungan COPQ berdasarkan perhitungan biaya scrap dan biaya repair. Batas kendali produk yang cacat berdasarkan perhitungan central line, upper control limit dan lower control limit. Hasil perhitungan nilai COPQ dalam periode bulan Juni, Juli dan Agustus sebesar Rp 4.468.872. dengan nilai proporsi jumlah produk yang cacat pada bulan Juni sebesar 0,037, Juli sebesar 0,046, dan Agustus sebesar 0,051. Peta kendali kualitas nilai CL sebesar 0,045, nilai UCL sebesar 0,051 dan nilai LCL sebesar 0,039. Nilai proporsi lebih kecil dari nilai UCL. Nilai COPQ masih dalam batas kendali.
COMPUTER SIMULATIONS OF CONTROLLABILITY PROCESSES FOR ROBOTIC WHEELED PLATFORMS TAKING INTO ACCOUNT RESTRICTIONS OF JERK MOTIONS
Authors: Alyokhina Svitlana , Nevliudov Igor , Romashov Yurii
Published: May 2022

The computer simulations are considered as the required tool to design the suitable autonomous control systems optimal in different senses and especially in providing the restrictions of the jerk motions for the robotic wheeled platforms. The subject matter of this research is the development of the theory and methods for computer simulations of the controllability processes of the robotic wheeled platforms. The goal of this research is to consider the jerks of the wheeled platforms, and the jerks are reduced to the limitation of the acceleration time derivative of the mass center of the wheeled platform, so that this derivative is considered as the quantitative estimation of the jerks. The incorrectness in the Hadamard's sense for direct defining the jerks by differentiations of the phase coordinates in the case of computer simulations using the numerical methods is discussed. Tasks of this research are in developing the generalized approaches for mathematical modelling and computer simulations and in theoretical receiving of the properties inherent for the wheeled platforms and suitable for verification the computer simulations results, as well as in making the calculations to have the quantitative results about the controllability processes for the particular case of the electromechanical four-wheeled platform under the straight motion with the mode of speeding-up from the state of the rest. Methods of this research are based on the Lagrange's equations of second kind, as well as on the electromechanical analogies, and on final representing the mathematical models in the form of the system of the first ordered ordinary differential equations with the initial conditions for further numerical solving. The computer simulations are accomplished by using the Scilab free open source software. Results of this research are in the proposed suitable way for computing the jerks by the phase coordinates without its differentiations allow excluding the incorrectness in the Hadamard's sense, as well as in representing the controllability processes for the electromechanical wheeled platform, including the results for the velocities, the accelerations and the jerks which are necessary to illustrate the controllability processes for the robotic wheeled platforms. By comparison with the theoretically established inherent properties of the wheeled platforms it is shown the correctness of the results of the computer simulations. Conclusions about this research are that the developed approaches for computer simulations of the controllability processes for the robotic wheeled platforms allow considering influence of the control on the different characteristics including the velocity, the acceleration, as well as the jerk motions which are required for designing the controls optimal in different senses.
ESTIMATION OF SOFTWARE COMPLEXITY OF CALCULATION OF AUTOREGRESSION COEFFICIENTS AT DIGITAL SPECTRAL ANALYSIS
Authors: Zuev Andrey , Ivashko Andrey , Lunin Denis
Published: May 2022

The subject of research in the article are algorithms for fast calculation of autoregression coefficients in digital spectral analysis and estimation of the number of arithmetic operations required for their implementation. The aim of the article – comparative analysis of the speed of different algorithms for calculating the coefficients of autoregression as part of the algorithms of spectral analysis, including analysis of the complexity of their microcontroller implementation. Tasks to be solved: selection of spectral analysis methods suitable for diagnostics of technological equipment, analysis of methods for calculating autoregression coefficients and derivation of relations for estimating software complexity of algorithms and calculation of numerical estimates of addition and multiplication for some algorithms, adaptation of developed methods and estimates to microcontrollers. spectrum Applied methods: algorithm theory, Fourier transform, natural series, microcontroller programming. The results obtained: it is shown that spectral estimation methods based on Yul-Walker equations, which require the calculation of autoaggression coefficients, combine sufficient resolution and resistance to interference with acceptable implementation complexity. Estimates of the number of additions and multiplications for the Levinson, Durbin, and Trench algorithms are obtained, and their comparative analysis is performed. The calculation times for microcontroller arithmetic with fixed and floating points were count upon. Conclusions: When constructing spectrum analyzers for the diagnosis of technological equipment, it is advisable to use the Yul-Walker method. A comparison of Levinson, Durbin, and Trench algorithms for calculating autoregression coefficients showed that the Trench method requires a minimum number of additions, and the Durbin method requires a minimum number of multiplications. At microcontroller realization of spectrum analyzers, it is necessary to consider features of the arithmetic used by the controller. The Trench method is the fastest in the case of floating-point arithmetic and small-scale modeling. In other cases, Durbin's method is more effective.
CARACTERIZAÇÃO SOCIODEMOGRÁFICA E CLÍNICA DE CRIANÇAS COM ESTOMIA: UM ESTUDO EPIDEMIOLÓGICO
Authors: Correia Priscilla Vogado , Melo Manuela Costa , Silva Ana Lúcia da , Kamada Ivone
Published: May 2022

Objetivo:Caracterizar o perfil clínico epidemiológico de crianças com estomia atendidas no ambulatório de um hospital público de ensino de referência na área infantil no Brasil. Método: Estudo descritivo, documental, retrospectivo e de natureza quantitativa, realizado por meio da extração de dados sociodemográficos e clínicos de prontuários eletrônicos de crianças com estomia, acompanhadas de 2014 a 2018. Os dados passaram por estatística descritiva e, na análise, foram organizados em uma planilha no programa Microsoft Excel versão 2010, distribuídas em três tabelas, seus valores representados em frequência absoluta e relativa. Resultados: Das 85 crianças com estomia, houve predominância do sexo masculino, idade entre 1 a 4 anos. Anomalia anorretal foi considerada o principal diagnóstico. Constatou-se elevado número de colostomias confeccionadas. Dermatite de contato foi a complicação periestomal mais frequente. Verificou-se a dificuldade na rotina de comparecimento das famílias ao ambulatório e constatou-se a mãe como cuidadora principal. Conclusão: O estudo concluiu relevantes aspectos relacionados ao planejamento do cuidado pautado na demanda de cada criança e na educação em saúde para a prevenção de complicações, ações indispensáveis na oferta do cuidado de enfermagem seguro e de qualidade, como também favorecer operacionalização das políticas públicas relacionadas à saúde da criança com estomias.
Intervenção Farmacêutica: descrição do papel do farmacêutico clínico em unidades de terapia intensiva
Authors: COLIN Stéphanie L. , NUTTI Camile
Published: May 2022

Objetivo: Descrever e analisar o perfil de intervenções farmacêuticas através da identificação e classificação dos problemas relacionados a medicamentos (PRM) e realização de intervenções farmacêuticas visando evidenciar a importância do farmacêutico clínico intensivista. Metodologia: Estudo transversal, descritivo e retrospectivo dos resultados do serviço de acompanhamento farmacoterapêutico direcionado aos pacientes críticos internados nas UTI’s Cardiológica e Geral de um hospital público estadual. Os dados foram coletados, no período de 01 de setembro de 2020 a 30 de março de 2021, por meio de relatório de acompanhamento farmacoterapêutico institucional e os PRM identificados, quantificados e classificados conforme a Pharmaceutical Care Network Europe. Os medicamentos envolvidos nos problemas foram categorizados utilizando o Anatomical Therapeutic Chemical. Resultados: Um total de 331 pacientes foram acompanhados no período do estudo, com identificação de 181 PRM. Destes, a maior parte foi relacionada à evento adverso (possivelmente) representando (34,8%) e indisponibilidade ou inadequação de apresentação farmacêutica (29,8%). As principais causas dos PRM identificados foram forma farmacêutica inadequada (19,3%) e medicamento prescrito não disponível (19,3%). A maior parte dos problemas (24%) relacionava-se à classe dos medicamentos que atuam no sistema nervoso e à classe dos anti-infecciosos gerais para uso sistêmico (23%). Das recomendações realizadas para a otimização da farmacoterapia, 98,3% foram aceitas sendo prevalente a sugestão de alteração da forma farmacêutica (22,1%). Conclusão: A alta aceitabilidade das intervenções sugeridas pelo farmacêutico clínico intensivista reforça a importância e necessidade dos serviços clínicos prestados por este profissional da saúde.
Implementasi Media Loose Parts untuk Mengembangkan Aspek Motorik Halus Anak Usia Dini
Authors: Setianingsih Asih , Handayani Iys Nur
Published: May 2022

Penelitian ini membahas mengenai pembelajaran media loose parts yang perlu diimplentasikan sebagai bahan ajar yang dapat digunakan oleh anak usia dini. Media pembelajaran berbasis loose parts  dapat memudahkan anak dalam pencapaian aspek perkembangan motorik halus anak. Penelitian ini bertujuan mengetahui implementasi media loose parts untuk mengembangkan aspek motorik halus anak usia dini. Penelitian ini menggunakan metode deskriptif kualitatif dimana peneliti akan secara spesifik dan alamiah menggambarkan terkait data berupa fakta-fakta secara nyata dari pelaksanaan pembelajaran. Teknik pengumpulan data pada penelitian ini menggunakan observasi, wawancara dan dokumentasi. Analisis data dalam penelitian diskriptif kualitatif yang datanya diperoleh melalui penelitian yang telah dilaksanakan di TK Hardikasiwi. Media loose parts menjadi salah satu solusi bagi pendidik untuk meningkatkan perkembangan anak melalui  keterampilan motorik halus. Media pembelajaran loose parts yang dilaksanakan di TK Hardikasiwi Sidomoro dalam proses kegiatan pembelajaran untuk mengembangkan aspek perkembangan motorik halus anak sudah berkembang dengan baik
Pembiasaan Nilai-Nilai Keagamaan dalam Mengasah Kecerdasan Spiritual Anak
Authors: Hafidz Nur , Kasmiati Kasmiati , Diana Raden Rachmy
Published: May 2022

Kekerasan seksual terjadi karena ruang keluarga sebagai tanggungjawab utama tidak memberi pelayanan edukasi keagamaan, sehingga anak-anak fase remaja terjerumus dalam kegiatan yang tidak bermanfaat melainkan merugikan spikis dan fisiknya. Tujuan penelitian ini untuk menanamkan sikap dan bentuk kecerdasan spiritual melalui pembiasaan nilai-nilai kegamaan sejak usia dini di lembaga pendidikan anak usia dini. Subjek penelitian kepada anak-anak usia 5-6 tahun dan guru di PAUD Wadas Kelir. Metode penelitian ini menggunakan penelitian kualitataif dengan pendekatan studi kasus. Teknik pengumpulan data menggunakan observasi dan wawancara mendalam. Data yang dikumpulkan kemudian dianalisis dengan teknik interaktif yakni, reduksi, penyajian data, dan penarikan kesimpulan. Hasil penelitiannya yang diperoleh dalam mengasah kecerdasan yaitu, (1) Bentuk pembiasaan keagamaan; pemberian hadiah, pemberian hukuman, pemberian nasehat, pembiasaan dengan keteladanan, dan pengondisian, (2) praktik pembiasaan keagamaan melalui metode; pembiasaan senyum-sapa-salam, pembiasan hafalan, pembiasaan cerita islami, pembiasaan tepuk dan lagu islami, dan pembiasaan praktik ibadah. (3) Implikasi Pengembangan Kecerdasan Spiritual anak.
Meningkatkan Kemampuan Motorik Halus melalui Messy Play
Authors: Nuryanah Siti , Ramdhani Luthfi Aji
Published: May 2022

Penelitian ini bertujuan untuk mengetahui perkembangan motorik halus pada anak usia 4-5 tahun melalui kegiatan messy play di Pos PAUD Kasih Bunda Desa Sidomoro. Penelitian ini menggunakan metode penelitian tindakan kelas (PTK) yang dikembangkan oleh Kemmis and Taggart dengan model spiral dimana pelaksanaannya dilakukan secara berulang-ulang dengan 4 tahapan yaitu perencanaan, tindakan, pengamatan dan refleksi. Subyek penelitian adalah anak usia 4-5 tahun yang jumlahnya 10 anak dengan menggunakan observasi dan dokumentasi. Penelitian ini di lakukan dengan 2 siklus selama 6 hari. Hasil penelitian untuk kemampuan motorik halus melalui messy play di nyatakan meningkat dengan indikator : mengikuti mencetak pasir sangat baik, menirukan membentuk dengan plastisin sangat baik, menunjukkan cara melukis dengan jari tangan( finger painting) sangat baik, membedakan biji-bijian sangat baik
The Ukraine Crisis: Causes, Conundrum and Consequences
Authors:   The University of Auckland, New Zealand, Cheng Manqing
Published: May 2022

Located at the geopolitical centre of Eurasia, Ukraine has been an important arena for great power game for nearly three decades since the collapse of the Soviet Union. The West, principally the United States and Europe, and the Russian Federation have therefore been heavily involved in Ukraine's internal and external development. Their ideological, economic, and geopolitical interests clashed in a fierce battle that led to multiple political regime changes in Ukraine, and ultimately plunged Europe into an intractable security situation. This paper takes the rivalry between the US, Europe and Russia in Ukraine as a starting point to examine the dilemma facing European security in the context of the great power game, the root causes behind the Ukraine crisis, its far-reaching consequences for geopolitics and global patterns and the implications for regional peace in other parts of the world.
The Development of Pragmatics in Morris’s Behavioral Semiotics: Semiotic Perspective
Authors:   Shinawatra University, Thailand, Niu Min , Dechsubha Thawascha
Published: May 2022

Many pragmaticists claimed that pragmatics developed mainly from 1970s and 1980s, taking the emergence of its series of pragmatic theories (e.g., Cooperative Principle, Conversation Implicature, Relevance Theory, etc.), methodology, and the official issue of Journal of Pragmatics (1977) in Amsterdam as its marks. However, few scholars reinstate the historical truth of the real development of pragmatics by comparing and reviewing the semiotic thoughts between Peirce and Morris so as to discover the development and prosperity of pragmatics in Morris’s times (around 1930s). As one of the founders of modern semiotics, Morris’s major contribution derives from his proposal of trichotomy theory of semiosis, that is, syntactics, semantics, and pragmatics, grounded on which Morris intends to establish an all-inclusive general theory of signs. Substantially, Morris’s semiotic theory involves rich pragmatic thought which is inherited and developed from Peirce theory of signs that has logic and pragmaticism as its foundations. This paper aims to reveal the formation and development of pragmatics in Morris’s behavioral semiotics by means of comparing the semiotic thoughts between Peirce and Morris from the perspective of dynamic history. Specifically, this paper involves the analysis of the philosophical foundations of pragmatics, disciplinary classification, the establishment of pragmatics, theory of sign inquiry, the relevant specific semiotic views, and three semiotic dimensions of Morris’s pragmatics, which are conducive to explore the pragmatic origin and development from the perspective of Morris’s semiotic thoughts. As such, Pragmatics in Morris’s behavioral semiotics is established and developed in a systematic and formal way.
COVID-19 Pandemic vs. Pre-Pandemic Period: Changes in Hospital Admission Rates, Length of Stay, and In-Hospital Mortality of Common Neurologic Conditions
Authors:   Jose R. Reyes Memorial Medical Center, Philippines, Leon Alessandra R. De , Go Criscely L.
Published: May 2022

Background and Objective: COVID-19 pandemic caused massive adjustments to healthcare systems in the country. This study determined the change in hospital admission rates, length of hospital stay and in-hospital mortality of common (non-COVID related) neurologic conditions during the COVID-19 pandemic and pre-pandemic period. Methods: The study utilized a retrospective cross-sectional study of patients admitted under the Department of Neurology at Jose R. Reyes Memorial Medical Center from the period of March 2019 to March 2020 (pre-pandemic group), and April 2020 to April 2021 (COVID-19 pandemic). Admission rates, length of stay and in-hospital mortality were calculated for cerebrovascular diseases, CNS infections, CNS neoplasms and Seizure disorders. Results: There were 1090 admissions from April 2019 to March 2020 and 393 admissions from April 2020 to March 2021 with an over-all decline of 63%. During the pandemic, the duration of hospital stay was longer for CNS neoplasms. Duration of hospital stay for cerebrovascular disease, CNS infection, and seizure disorders were not significantly different. There was an increase in over-all in hospital mortality from 22.75% to 26.46% with significant increase in the case fatality rate of cerebrovascular diseases. Conclusion: We observed a large decline in the over-all admission rate and longer hospital stays. The over-all in-hospital mortality rate also increased during the pandemic period.
A COMUNICAÇÃO NA POLÍTICA PÚBLICA EDUCACIONAL COMO ELEMENTO DE FORMAÇÃO DE PRÁTICA PEDAGÓGICA REFLEXIVA NA REDE DE ENSINO DE SAPUCAIA - PA
Authors: CORREA VASTI DE PAULA
Published: May 2022

Nesta dissertação, estuda-se a formação continuada como elemento formador para construção da prática pedagogia reflexiva na rede de ensino municipal no município de Sapucaia/PA, tomando como ponto de partida a aplicação de políticas públicas educacionais. Com isto, o problema de pesquisa se resume na seguinte indagação: Como ocorre a implementação das Políticas públicas educacionais diante da Formação continuada como elemento formador para construção da prática pedagogia reflexiva na rede de ensino municipal no município de Sapucaia/PA, Deste jeito, o principal objetivo deste estudo é analisar a implementação das Políticas públicas educacionais diante da Formação continuada como elemento formador para construção da prática pedagogia reflexiva na rede de ensino municipal no município de Sapucaia/PA. Como específicos, por sua vez, apresentam-se as seguintes tarefas: 1º) Verificar de que maneira ocorre a aplicabilidade das Políticas Públicas Educacionais no espaço escolar para a melhoria do ensino; 2º) Descrever se a formação continuada é exercida como elemento formador para a construção de um ensino de qualidade; 3º) identificar como a prática pedagógica reflexiva vem sendo implementada no contexto escolar para a formação discente. Nos últimos anos, o Ministério da Educação vem investindo nas políticas públicas educacionais na tentativa de buscar a qualidade do ensino público brasileiro. Aliás, entre estas ações se destacam as políticas de formação continuada. Portanto a formação torna-se um mecanismo formador essencial por proporcionar uma melhor preparação do professor no desenvolvimento de suas atividades, incluindo-se aqui a gestão de uma educação de qualidade com maior frequência. Em suma, estas são as principais idéias que são trabalhadas nesta atividade dissertativa.
A single nucleotide variant on chromosome 16 residing within CALB2 distinguishes patients with luminal A breast cancer.
Authors: Mamoor Shahan
Published: May 2022

Molecular subtypes including the most common subtype luminal A drive patient outcomes in human breast cancer but the biological basis for this is not completely understood (1-4). We mined published microarray data (5, 6) to discover in an unbiased fashion the most distinguishing genetic and transcriptional features of tumors of each breast cancer molecular subtype. We identified a single nucleotide polymorphism, rs9940728, residing within CALB2, as among the most significant genetic differences in the tumors of patients with luminal A breast cancer. In a separate cohort of patients with luminal A subtype breast cancer, we observed transcriptome-wide differential expression of a CALB2 transcript. Analysis of patient survival data revealed that CALB2 primary tumor expression was correlated with overall survival in patients with basal-like, luminal B and HER2+ subtype breast cancer. Sequence variation in the CALB2 gene may be important in understanding differences in genetic background that favor development of luminal A subtype human breast cancer.
The Development of Pragmatics in Morris’s Behavioral Semiotics: Semiotic Perspective
Authors: Niu Min , Dechsubha Thawascha
Published: May 2022

Many pragmaticists claimed that pragmatics developed mainly from 1970s and 1980s, taking the emergence of its series of pragmatic theories (e.g., Cooperative Principle, Conversation Implicature, Relevance Theory, etc.), methodology, and the official issue of Journal of Pragmatics (1977) in Amsterdam as its marks. However, few scholars reinstate the historical truth of the real development of pragmatics by comparing and reviewing the semiotic thoughts between Peirce and Morris so as to discover the development and prosperity of pragmatics in Morris’s times (around 1930s). As one of the founders of modern semiotics, Morris’s major contribution derives from his proposal of trichotomy theory of semiosis, that is, syntactics, semantics, and pragmatics, grounded on which Morris intends to establish an all-inclusive general theory of signs. Substantially, Morris’s semiotic theory involves rich pragmatic thought which is inherited and developed from Peirce theory of signs that has logic and pragmaticism as its foundations. This paper aims to reveal the formation and development of pragmatics in Morris’s behavioral semiotics by means of comparing the semiotic thoughts between Peirce and Morris from the perspective of dynamic history. Specifically, this paper involves the analysis of the philosophical foundations of pragmatics, disciplinary classification, the establishment of pragmatics, theory of sign inquiry, the relevant specific semiotic views, and three semiotic dimensions of Morris’s pragmatics, which are conducive to explore the pragmatic origin and development from the perspective of Morris’s semiotic thoughts. As such, Pragmatics in Morris’s behavioral semiotics is established and developed in a systematic and formal way.
Where are our false positives?
Authors: Perezgonzalez Jose D.
Published: May 2022

In our current regime of COVID-19 testing, a question seems not to be asked: Are we inferring the best we can from our results? Or, put differently, are we testing with severity? This study thus explore the proportion of expected positives and negative cases, with an especial focus on estimating false positives in isolation and estimating false (or unknown) negatives in the remaining population. Both seems to have been chiefly ignored by Government health policy.
Thảo luận về ngành du lịch sau hai năm Covid-19
Authors: Anh Nguyen Huyen , Duong Thuy , Minh Pham Nang , Phương Triệu Lan , Linh Dang Khanh
Published: May 2022

Trải qua hai năm đại dịch Covid-19, ngành du lịch đang có xu hướng khởi sắc, dần dần phục hồi và phát triển trở lại.
The COVID-19 Rapid Survey of Adherence to Interventions and Responses (CORSAIR) study: errata
Authors: Smith Louise E , Potts Henry , Amlôt Richard , Fear Nicola T. , Michie Susan , Rubin James
Published: May 2022

Since February 2020, we have been working with the Department of Health and Social Care on a series of surveys, the COVID-19 Rapid Survey of Adherence to Interventions and Responses (CORSAIR) study. This entails a series of cross-sectional national (UK) surveys of approximately 2000 participants per wave, recruited via two survey panels. Surveys have been conducted weekly or fortnightly since the end of January 2020, with 73 waves of data collection to date (correct at time of writing: 20 April 2022). There have been some errors with the datasets delivered to us. We have re-analysed those of our previously reported results that are affected by these corrections. The changes make very little difference to any of our conclusions.
TEMA DAN LEGENDA SERTA KETERKAITAN DENGAN PENDIDIKAN IPS
Authors: Zulfah Siti
Published: May 2022

Legenda menurut Danandjaja (1984: 66) bersifat sekuler (keduniawian), terjadinya pada masa yang belum begitu lampau, dan bertempat di dunia seperti yang kita kenal sekarang. Tema menurut Stanton via Nurgiyantoro (2002: 67) adalah makna yang dikandung dalam sebuah cerita. Hal yang sangat dekat dengan tema adalah amanat, yaitu pesan dan saran yang akan disampaikan kepada pembaca. Secara lengkap, amanat merupakan suatu pesan yang terdapat dalam sebuah cerita dalam hal ini adalah legenda yang biasanya merupakan himbauan, ajakan, dan motifasi berupa hal-hal yang pada umumnya bersifat positif.
My thoughts on the power of mindsponge and the BMF
Authors: Le Tam-Tri
Published: May 2022

I think mindsponge and the BMF are powerful tools in thinking and doing science.
Internal Capability of the State Matters in International Relations: Evidence from East African Tri-national Border Zone
Authors: Sana Olang , Ludeki Chweya
Published: May 2022

The realist theoretical perspective suggests that the ‘inside’ of the state is not a critical variable since, unlike the anarchical international system, the domestic arena entails a sovereign entity in form of a government which is able to exercise effective authority, secure compliance from citizens, and guarantee internal order. However, studies continue to expose a litany of states especially in the developing world, whose weaknesses can be attributed to domestic antagonism. Consequently, the states face external security threats due to such internal incapacity gaps. This article draws data from Kenya, Uganda and South Sudan to demonstrate that internal capacity of states matter in international relations. The study establishes that the three states have been unable to establish effective authority over the pastoral Turkana, Karamojong and Toposa who reside in their respective territorial jurisdictions and this weakness has a corresponding effect on the ability of the state to promote its national interest, which is mainly security. The article therefore, argues that while realism still remains a compelling theoretical perspective for conceptualizing security in the international system, it could be strengthened by paying attention to the domestic variable.
RESUME EKONOMI MAKRO SYARIAH "KESEIMBANGAN PASAR UANG DAN PASAR BARANG DALAM EKONOMI MAKRO ISLAM"
Authors: Nurhayati
Published: May 2022

Pasar barang merupakan pasar yang dimana tempat bertemunya penawaran dan permintaan atas sebuah barang atau jasa. Biasanya pasar barang ini disebut atau lebih dikenal dengan istilah sektor rill. Keseimbangan pasar uang merupakan kurva yang menghubungkan titik tingkat sebuah pendapatan nasional kepada berbagai macam kemungkinan dari tingkat buga yang memelihara keseimbangan pasar uang.Kesimbangan pada pasar barang (keseimbangan pada sektor riil), menggambarkan kondisi perekonomian dipandang dari sisi permintaan dan penawaran barang dan jasa. Sisi penawaran menggambarkan kemampuan perekonomian dalam menghasilkan barang dan jasa pada suatu periode tertentu.
Optical Neuromorphic Processor Operating at 11 TeraOPs/s based on Kerr Soliton Crystal Micro-combs
Authors: Moss David
Published: May 2022

We demonstrate a universal optical vector convolutional accelerator operating at 11 Tera-OPS, generating convolutions of images of 250,000 pixels with 8-bit resolution for 10 kernels simultaneously. We use the same hardware to form a deep optical CNN with ten output neurons, achieving successful recognition of full 10 digits with 88% accuracy. Our approach is scalable and trainable for applications to unmanned vehicle and real-time video recognition.
A single nucleotide variant on chromosome 16 residing within COTL1 distinguishes patients with luminal A breast cancer.
Authors: Mamoor Shahan
Published: May 2022

Molecular subtypes in human breast cancer include the PAM50 molecular subtypes luminal A, luminal B, basal or basal-like, and HER2+. Molecular subtypes - including the most common subtype luminal A - drive patient outcomes in human breast cancer but the biological basis for this is not completely understood (1–4). We mined published microarray data (5, 6) to discover in an unbiased fashion the most distinguishing genetic and transcriptional features of tumors of each breast cancer molecular subtype. We identified a single nucleotide polymorphism, rs247861, residing within COTL1, as among the most significant genetic differences in the tumors of patients with luminal A breast cancer. In a separate cohort of patients with luminal A subtype breast cancer, we observed transcriptome-wide differential expression of a COTL1 transcript. Analysis of patient survival data revealed that COTL1 primary tumor expression was correlated with overall survival in patients with basal-like, luminal B and HER2+ breast cancer. Sequence variation in the COTL1 gene may be important in understanding differences in genetic background that favor development of luminal A subtype human breast cancer.