bluuebunny/crossref_metadata_2025 huggingface dataset:
Association of TGFB1 rs1800469 and BCMO1 rs6564851 with coronary heart disease and IL1B rs16944 with all-cause mortality in men from the Northern Ireland PRIME study
Authors: Mooney Rachel E. , Linden Gerry J. , Winning Lewis , Linden Katie , Kee Frank , McKeown Pascal P. , Woodside Jayne V. , Patterson Christopher C. , McKay Gareth J.
Published: August 2022

Background

Historically, high levels of morbidity and mortality have been associated with cardiovascular disease in the Northern Ireland population. Previously reported associations between single nucleotide polymorphisms (SNPs) and cardiovascular disease within other populations have not always been consistent.

Objective

To investigate associations between 33 SNPs with fatal or non-fatal incident coronary heart disease (CHD) events and all-cause mortality in the Northern Irish participants of the Prospective Epidemiological Study of Myocardial Infarction (PRIME).

Method

Phase 2 of the PRIME study prospectively evaluated 2,010 men aged 58–74 years in Northern Ireland for more than 10 years for incident CHD events (myocardial infarction, percutaneous coronary intervention, coronary artery bypass, and cardiac death) and more than 15 years for all-cause mortality. SNPs previously reported in association with cardiovascular outcomes were evaluated against incident CHD events and all-cause mortality using Cox’s proportional hazards models adjusted for established cardiovascular disease risk factors.

Results

During the follow-up period, 177 incident CHD events were recorded, and 821 men died. BothBCMO1rs6564851 (Hazard ratio [HR] = 0.76; 95% confidence intervals [CI]: 0.60–0.96; P = 0.02) andTGFB1rs1800469 (HR = 1.30; CI: 1.02–1.65; P = 0.04) were significantly associated with incident CHD events in adjusted models. OnlyIL1Brs16944 was significantly associated with all-cause mortality (HR = 1.18; CI: 1.05–1.33; P = 0.005). No associations remained significant following Bonferonni correction for multiple testing.

Conclusion

We report a novel association betweenBCMO1rs6564851 and risk of incident CHD events. In addition,TGFB1rs1800469 andIL1Brs16944 were associated with the risk of incident CHD events and all-cause mortality outcomes respectively, supporting previously reported associations.
Analysing frequent extreme flood incidences in Brahmaputra basin, South Asia
Authors: Kumar Amit , Mondal Subhasree , Lal Preet
Published: August 2022

The present study is focused on the flood inundation in Brahmaputra Basin, which is one of the most recurrent and destructive natural disasters of the region. The flood inundation was assessed using C-Band Sentinel 1A synthetic aperture radar (SAR) during 2015–2020 with precipitation patterns, runoff discharge, and their impacts on land cover in the basin. The study exhibited a very high precipitation during monsoon in the upper catchment resulting in severe flood inundation in downslopes of Brahmaputra Basin. A very high (900–2000 mm) to extremely high (>2000 mm) monthly cumulative precipitation in the south and south-eastern parts of basin led to high discharge (16,000 to 18,000 m3s-1) during July-August months. The river discharge increases with cumulative effects of precipitation and melting of snow cover during late summer and monsoon season, and induced flood inundation in lower parts of basin. This flood has largely affected agricultural land (>77% of total basin), forests (~3%), and settlement (426 to 1758 km2) affecting large wildlife and livelihood during 2015–2020. The study highlights the regions affected with recurrent flood and necessitates adopting an integrated, multi-hazard, multi-stakeholder approach with an emphasis on self-reliance of the community for sustenance with local resources and practices.
An apical protein, Pcr2, is required for persistent movement by the human parasite Toxoplasma gondii
Authors: Munera Lopez Jonathan , Tengganu Isadonna F. , Liu Jun , Murray John M. , Arias Padilla Luisa F. , Zhang Ying , Brown Peter T. , Florens Laurence , Hu Ke
Published: August 2022

The phylum Apicomplexa includes thousands of species of unicellular parasites that cause a wide range of human and animal diseases such as malaria and toxoplasmosis. To infect, the parasite must first initiate active movement to disseminate through tissue and invade into a host cell, and then cease moving once inside. The parasite moves by gliding on a surface, propelled by an internal cortical actomyosin-based motility apparatus. One of the most effective invaders in Apicomplexa is Toxoplasma gondii, which can infect any nucleated cell and any warm-blooded animal. During invasion, the parasite first makes contact with the host cell "head-on" with the apical complex, which features an elaborate cytoskeletal apparatus and associated structures. Here we report the identification and characterization of a new component of the apical complex, Preconoidal region protein 2 (Pcr2). Pcr2 knockout parasites replicate normally, but they are severely diminished in their capacity for host tissue destruction due to significantly impaired invasion and egress, two vital steps in the lytic cycle. When stimulated for calcium-induced egress, Pcr2 knockout parasites become active, and secrete effectors to lyse the host cell. Calcium-induced secretion of the major adhesin, MIC2, also appears to be normal. However, the movement of the Pcr2 knockout parasite is spasmodic, which drastically compromises egress. In addition to faulty motility, the ability of the Pcr2 knockout parasite to assemble the moving junction is impaired. Both defects likely contribute to the poor efficiency of invasion. Interestingly, actomyosin activity, as indicated by the motion of mEmerald tagged actin chromobody, appears to be largely unperturbed by the loss of Pcr2, raising the possibility that Pcr2 may act downstream of or in parallel with the actomyosin machinery.
The evolution of immersed locally convex plane curves driven by anisotropic curvature flow
Authors: Wang Yaping , Wang Xiaoliu
Published: August 2022

In this article, we study the evolution of immersed locally convex plane curves driven by anisotropic flow with inner normal velocityV=1αψ(x)καV=\frac{1}{\alpha }\psi \left(x){\kappa }^{\alpha }forα<0\alpha \lt 0orα>1\alpha \gt 1, wherex∈[0,2mπ]x\in \left[0,2m\pi ]is the tangential angle at the point on evolving curves. For−1≤α<0-1\le \alpha \lt 0, we show the flow exists globally and the rescaled flow has a full-time convergence. Forα<−1\alpha \lt -1orα>1\alpha \gt 1, we show only type I singularity arises in the flow, and the rescaled flow has subsequential convergence, i.e. for any time sequence, there is a time subsequence along which the rescaled curvature of evolving curves converges to a limit function; furthermore, if the anisotropic functionψ\psiand the initial curve both have some symmetric structure, the subsequential convergence could be refined to be full-time convergence.
Flexible digital twins from commercial off-the-shelf software solutions: a driver for energy efficiency and decarbonisation in process industries?
Authors: Alford Molly , Udugama Isuru , Yu Wei , Young Brent
Published: August 2022

The term ‘digital twin’ refers to a virtual simulation/model (virtual twin) of a physical plant or object (physical twin), where data flows between the virtual and physical twins. A digital twin can be used for different purposes, such as process optimisation/control, design, training, and maintenance/service. This manuscript found an increasing number of simulation and modelling publications in literature year on year, which illustrates the current trend towards implementing digital twins in a broad range of process engineering applications. A targeted literature review into the area found several commercial off-the-shelf software solutions (COTS) for different industrial applications providing the necessary flexibility to analyse a broad range of industries. However, most of the process modelling software is designed for petroleum and fine chemicals processes. There is still a need for software solutions that can model a broader range of applications. While most of the software found was licensed, open source process modelling software was also available. There is a lack of independent research into the accuracy of these software solutions. The literature review also found that 37% of the research based on process simulations is carried out to improve energy efficiencies. In comparison, 27% of the research found Decarbonization to be a secondary "added" benefit. It can be concluded that digital twins are ideally suited for driving energy efficiency improvements and decarbonisation goals. However, none of the COTS identified in the literature meets all the requirements for a digital twin. A solution to this problem is to create a layered digital twin, combining and interfacing different tools to accomplish a visually similar, self-optimising, self-learning virtual plant.
Understanding the Usefulness of E-Portfolios: Linking Artefacts, Reflection, and Validation
Authors: Lam Ricky
Published: August 2022

E-Portfolios in language education have emerged over two decades. Despite their popularity as an instructional tool, many cast doubt on their usefulness in second language classrooms, especially when scholars are not clear about how e-Portfolio artefacts can be converted into reliable learning evidence by students’ active reflection and validation via multimedia feedback to inform language teaching and learning. This paper examines the usefulness of e-Portfolios by looking into how teachers attempt the tool to connect portfolio evidence, rationalisation, and feedback. Three novice teachers with three-year school experience (Jill, Jamie, and Jackie) undertook action research projects in their secondary schools. They participated in the study by trying out their individual e-Portfolio programmes for a year. Qualitative data, including two classroom observations and three reflective journal entries per teacher were collected by the author. Content analysis of qualitative data (i.e., lesson observation transcripts and journal entries) was performed deductively. The findings showed that except Jamie, Jill and Jackie hardly enhanced the usefulness of e-Portfolios, because they could not empower students to link artefacts, reflection, and validation properly owing to multiple reasons. Pedagogical implications concerning how to scale up the usefulness of e-Portfolio in L2 classroom contexts are discussed.
Network Analysis of Price Comovements Among Corn Futures and Cash Prices
Authors: Xu Xiaojie , Zhang Yun
Published: August 2022

Due to significant implications for resource and food sectors that directly influence social well-being, commodity price comovements represent an important issue in agricultural economics. In this study, we approach this issue by concentrating on daily prices of the corn futures market and 496 cash markets from 16 states in the United States for the period of July 2006 – February 2011 through correlation based hierarchical analysis and synchronization analysis, which allow for determining interactions and interdependence among these prices, heterogeneities in price synchronization, and their changing patterns over time. As the first study of the issue focusing on prices of the futures and hundreds of spatially dispersed cash markets for a commodity of indubitable economic significance, empirical findings show that the degree of comovements is generally higher after March 2008 but no persistent increase is observed. Different groups of cash markets are identified, each of which has its members exhibit relatively stable price synchronization over time that is generally at a higher level than the synchronization among the futures and all of the 496 cash markets. The futures is not found to show stable price synchronization with any cash market. Certain cash markets have potential of serving as cash price leaders. Results here benefit resource and food policy analysis and design for economic welfare. The empirical framework has potential of being adapted to network analysis of prices of different commodities.
Metabolically healthy obesity in a paediatric obesity clinic
Authors: Teixeira Diana , Martins Cátia , Oliveira Guiomar , Soares Raquel
Published: August 2022

Objectives

Metabolically healthy obese (MHO) children is a described subgroup of obese children who do not exhibit traditional cardiometabolic risk factors. The aim of this study was to determine the prevalence and characterize patients with this phenotype.

Methods

Cross-sectional study, performed in a paediatric obesity clinic (tertiary university hospital) in 2019. Children were classified with “MHO” or “metabolically unhealthy obesity” according to the criteria proposed by Damanhoury based on HDL, triglycerides, systolic and diastolic blood pressure (DBP) and fasting glucose values.

Results

241 participants were included, with ages between two and 17 years. The prevalence of the MHO phenotype was 61.8%. The body mass index (Z-score) in children aged five years or older was significantly lower in those with MHO (p=0.040). In the MHO group, mean total cholesterol levels were higher (p<0.001), due to the high value of HDL (p<0.001); triglyceride levels (p<0.001), systolic blood pressure (SBP) (p=0.036), DBP (p=0.029) and the homeostasis model assessment – insulin resistance (HOMA-IR) index (p=0.001) were significantly lower. HDL (OR=1.421; 95% CI 1.279–1.579; p<0.001) and SBP (OR=0.943; 95% CI 0.903–0.985; p=0.008) were the only independent predictors for the development of MHO.

Conclusions

Almost two-thirds of the participants had an MHO phenotype. The high and low values of HDL and SBP, respectively, were the only variables that proved to be predictors of MHO.
Prenatal predictors of adverse perinatal outcome in congenital cytomegalovirus infection: a retrospective multicenter study
Authors: Mappa Ilenia , De Vito Marika , Flacco Maria Elena , di Mascio Daniele , D’Antonio Francesco , Rizzo Giuseppe
Published: August 2022

Objectives

To identify predictors of adverse perinatal outcome in congenital cytomegalovirus (CMV) infection.

Methods

In a multicenter study fetuses with congenital CMV infection diagnosed by PCR on amniotic fluid and normal prenatal imaging at the time of diagnosis were included. Primary outcome was the occurrence of structural anomalies at follow-up ultrasound or prenatal magnetic resonance imaging (MRI). Secondary outcomes were the occurrence of anomalies detected exclusively postnatally and the rate of symptomatic infection.

Results

One hundred and four fetuses with congenital CMV were included in the study. Anomalies were detected at follow-up ultrasound or MRI in 18.3% (19/104) cases. Additional anomalies were found after birth in 11.9% (10/84) of cases and 15.5% (13/85) of newborns showed clinical symptoms related to CMV infection. There was no difference in either maternal age (p=0.3), trimester (p=0.4) of infection and prenatal therapy (p=0.4) between fetuses with or whiteout anomalies at follow-up. Conversely, median viral load in the amniotic fluid was higher in fetuses with additional anomalies at follow-up (p=0.02) compared to those without. At multivariate logistic regression analysis, high viral load in the amniotic fluid, defined as ≥100,000 copies/mL was the only independent predictor for the occurrence of anomalies detected exclusively at follow-up ultrasound assessment or MRI, with an OR of 3.12.

Conclusions

Viral load in the amniotic fluid is a strong predictor of adverse perinatal outcome in congenital CMV infection. The results of this study emphasize the importance of adequate follow up even in case of negative neurosonography to better predict postnatal adverse outcomes of infected newborns, especially in amniotic fluid high viral load.
Functions of the-êysuffix in Hyow
Authors: Zakaria Muhammad
Published: August 2022

This paper presents an extensive discussion on the functions of the-êysuffix in Hyow, a Southeastern Kuki-Chin (henceforth, KC) language spoken by approximately four thousand people in the Chittagong Hill Tracts of Bangladesh. The attested use of the-êysuffix in Hyow is of interest because of its use in two opposite syntactic structures. Although the straightforward function of the-êysuffix resembles that of middle voice, its other use in prototypical transitive clauses makes it difficult to assign a category to the suffix in question. This paper deals with this anomaly in the functional domains of the-êysuffix in Hyow with empirical data and makes suggestions of a category to be assigned to this suffix.
I. Erzähltes Recht – Neue Wege zum mittelalterlichen Rechtsbegriff
Authors: Dilcher Gerhard
Published: August 2022

Narrations of Law. New paths to a conception of medieval law. The article, starting from a review of two publications on medieval Scandinavian literature, tries to find out the role of law in the sagas of medieval Iceland, dealing with mostly bloody conflicts in a society without a ruler or state. Different from classical legal history, today we have to understand law in this context not as a systematic order of norms, but instead as an oral tradition in a world of mainly violent solutions of conflicts by revenge, partly by mediation or arbitration, seldom through a legal proceeding. Not a norm of law, but a compensation in relation to the honour or social position of the parties is the key for a solution. – The theory of a radical cultural change in history (axial age) turns out to be useful for understanding the changing role of law in medieval societies, including Scandinavia.
III. Zunft und Unordnung
Authors: Kunstreich Jasper
Published: August 2022

Guilds between authority and opposition. This paper compares the legal status of guilds in two German towns of the late Middle Ages: Frankfurt am Main and Hamburg. Both cities represented commercial hubs, Frankfurt with its privilege to hold fairs, Hamburg as a port town and member of the Hanse. Both cities also witnessed unrest and public protest by guilds during the second half of the 14th century. This article argues that those conflicts erupted over the guilds’ attempts to formalise their legal status by having their statutes written and acknowledged by the city council. The council eventually pre-empted those attempts. This happened through a process of bargaining that can be subdivided into three different stages: production of written demands or statutes, destabilisation, escalation. Putting something into writing created a qualitative distinction to orality in a society that was predominantly communicating orally and in presence. Thus, the latter was still the mode of political communication, mainly by swearing an oath, that could settle these conflicts. Where this process failed, the conflict could erupt into open violence, which in turn could only be settled by outside intervention – as in the case of Frankfurt.
IV. Konrad Maurers Briefe in öffentlichen Sammlungen mit einer Probe seiner Briefe aus Christiania 1876
Authors: Fix Hans
Published: August 2022

Konrad Maurer’s Letters in Public Library and Archive Collections. This paper accounts for both the hitherto little known depositories and the considerable amount of widely dispersed letters that came down to us written by Konrad Maurer, professor of law in Munich, between 1846 and 1900 to colleagues and friends in Germany, England, the Nordic Countries, and the United States of America. This account is supplemented by lists of letters both of Konrad Maurer’s wife Valérie on his behalf and of the relatively few letters to Konrad Maurer that have survived.
Anmerkungen zur Edition „De Saksenspiegel in Nederland, Eerste stuk – Oudere tekst“ von Barthold Jacob Lintelo Baron de Geer van Jutphaas
Authors: Holfeld Raphael
Published: August 2022

Notes on the edition ‘De Saksenspiegel in Nederland, Eerste stuk – Oudere tekst’ of Barthold Jacob Lintelo Baron de Geer van Jutphaas. The article sheds light on the Dutch Sachsenspiegel, which has hardly been noticed in research so far, and gives an overview of the manuscripts, their history and relationship. The only comparative edition from 1888 contains both textual and methodological errors in the first volume on the older text. This article concludes with a correction of the edition’s most significant deficiencies.
U.S. Women Need the Dapivirine Ring, Too: FDA as Structural Barrier to HIV Prevention for Women
Authors: Gollub Erica L. , Vaughan Raven
Published: August 2022

The dapivirine monthly vaginal ring—a discreet, anti-HIV microbicide created specifically for women—has received a positive scientific opinion by the European Medicines Agency and is included in the WHO HIV prevention guidelines. It has received regulatory approvals in several countries in southern and eastern Africa. During the review of the New Drug Application that was submitted in December 2020, FDA advised the developer, International Partnership for Microbicides, that it was unlikely to be approved in the United States; the application has since been withdrawn. This commentary will present the case for FDA approval for the dapivirine ring. Advocacy is urgently needed to protect U.S. women's access to user-controlled HIV prevention technologies, consistent with both global regulatory decisions to date and with a reproductive justice framework. Women continue to need the fullest range of HIV prevention methods to integrate into their lives in the most practical and effective way possible.
Substantial Increase in Transactional Sex and HIV Risk Among Adolescents During the COVID-19 Pandemic: Results From a Repeated Cross-Sectional Study in Botswana
Authors: Sun Christina J. , Seloilwe Esther S. , Magowe Mabel , Dithole Kefalotse , Lawrence Janet S. St.
Published: August 2022

The COVID-19 pandemic and resulting public health response has disrupted the lives of adolescents and their families worldwide. We evaluated the impact of the pandemic on attitudes, beliefs, and sexual risk behavior among adolescents in Botswana. Participants were recruited using household-based sampling across residential districts (blocks) in and around Gaborone, Botswana, and completed surveys on laptop computers at a private, central location. We compared baseline survey data from 380 adolescents who completed the survey pre-pandemic (n = 139) to those who completed the survey intra-pandemic (n = 241). Participants had a mean age of 15.2 years; 58.6% were girls and 41.4% were boys. Intra-pandemic, participants reported greater engagement in transactional sex (38.1% compared to 13.6% pre-pandemic, p <. 05), more favorable attitudes toward transactional sex with sugar daddies and sugar mommies (p <. 05), greater intentions to remain sexually active in the future (29.2% vs.13.6%, respectively, p <.05), and lower self-efficacy in handling risky sexual situations (p < .01). Public health interventions that lessen these concerning shifts in attitudes and behaviors will be key to protecting the sexual health of adolescents and to supporting their safe transition to adulthood.
REASONS FOR CHOOSING SOCIAL WORK AS PROFESSION: A CASE STUDY OF PROSPECTIVE STUDENTS AT THE UNIVERSITY OF LIMPOPO
Authors: Mmadi Pontsho James
Published: August 2022

The current number of social workers in South Africa is worryingly low. Whereas the motives for pursuing social work as a career have been documented, over the course of time things change and it is not possible to know or assume what motivated the current cohort of students. Thus, ongoing research is vital. A document analysis research that was qualitative in nature was undertaken at the University of Limpopo, where a selection test questionnaire in the form of open-ended questions was administered to 141 prospective students. The findings of a thematic analysis indicate that aspirations to pursue social work are influenced by family, school teachers, social workers in the field and a desire for self-healing. Keywords: career paths, prospective social work students, social work profession, University of Limpopo
Angiorganoid: vitalizing the organoid with blood vessels
Authors: Ma Xiaojing , Li Hongfei , Zhu Shuntian , Hong Zixuan , Kong Weijing , Yuan Qihang , Wu Runlong , Pan Zihang , Zhang Jing , Chen Yahong , Wang Xi , Wang Kai
Published: August 2022

The emergence of the organoid simulates the native organs and this mini organ offers an excellent platform for probing multicellular interaction, disease modeling and drug discovery. Blood vessels constitute the instructive vascular niche which is indispensable for organ development, function and regeneration. Therefore, it is expected that the introduction of infiltrated blood vessels into the organoid might further pump vitality and credibility into the system. While the field is emerging and growing with new concepts and methodologies, this review aims at presenting various sources of vascular ingredients for constructing vascularized organoids and the paired methodology including de- and recellularization, bioprinting and microfluidics. Representative vascular organoids corresponding to specific tissues are also summarized and discussed to elaborate on the next generation of organoid development.
The Influence of Globalization on the Development of Educational Management
Authors: Savkiv Uliana , Sydor Halyna
Published: August 2022

The article substantiates the impact of globalization on the system of management of education and identifies the main directions of its impact on education. Management of the educational sphere in modern conditions determines the procedure for the establishment and legalization of educational institutions, formation of decisions in the educational sphere, support of the vital activity of the structure and control over functioning and development of educational institutions. In conditions of the globalized world in management of education the issues related to supporting educational initiatives and innovations, creating conditions for stable functioning and development of educational systems, development and self-realization of participants in the educational process, legal and economic protection of education, forecasting and making optimal decisions. designing optimal models of educational systems come to the forefront. On the basis of the analysis of scientific works of the leading domestic and European researchers, the tasks of management of education in conditions of globalization have been summarized: definition of strategies of educational activities, improvement of methodologies of quality of management of education taking into account current trends in social development, working out of innovative approaches to management of educational services, intensification of European integration processes, introduction of information technologies in the system of management of education, development of mechanisms for regulating educational activities in a market environment, modification of scientific approaches to human resources management in education and modernization of training of specialists in management of education. The main ways for improving modern management in the process of implementation of educational policy in Ukraine have been proposed.
Socio-cultural foundations of discourse and modern transformation
Authors: Proleiev Serhii
Published: August 2022

The article considers the place and role of discourse in human life. The basis for this is the im- portance of language and speech as one of the leading features of humanity. Thanks to language, a person’s own reality is formed, which has a semantic character. Four dimensions of the effect of speech in the constitution of the human world are identified. These are: the function of se- mantic productivity and reliability of speech; function of organization and accumulation of ex- perience; the function of normativity of human life; personalization function. The acquisition of the discourse format by speech is associated with the assertion of significance and substantiation of the validity of judgments. These qualities of discursive practices are inseparable from their normative effect. If speech as such is dominated by the effect of communication and statements, the discourse is primarily a semantic ordering of reality. It always creates, transforms or cancels a certain semantic order. The thesis on the growing role of discursive practices in the contempo- rary world is substantiated. This is due to the epoch-making changes in human life, namely the end of the era of production. The whole history of human civilization can be represented as the development of production (from the invention of the production mode of economy in the form of the Neolithic revolution). The end of the era of production means at the same time the actu- alization of the great historical task of man’s appeal to himself, to his own nature and organic ability to live. Taking care of yourself, not the conditions of existence (external goods) will be a priority for human development in the near historical perspective. However, this reorientation of human existence is confronted with the contradictory impact of virtualization of reality for man, which entails changes in the classical vocation of discourse. In this regard, the effect of discourses in the highly powerful information environment of today is analyzed, which is becoming the leading force of global reality in the form of information power.
Discursive dimension of institutions
Authors: SHAMRAI Viktoria
Published: August 2022

The article considers the leading and indisputable role of discursive practices in the existence of social institutions, especially in democratic governance. The necessity of searching for heuristi- cally effective approaches in the analysis of social reality in general, and especially modern soci- ality, is substantiated. In this context, the theoretical modernization of the institutional approach in the analysis of social phenomena by involving the concept of discourse in the structure of this approach is proposed. Emphasis is placed on the dual meaning of social institutions — as ways of organizing the life of society and as instances (mediums) of normative, through which the order of social life is constituted, reproduced, and changed. This solves the “rule-organization” dilem- ma in neo-institutionalism. It is transferred to the mode of two inseparable and complementary functions of the institute — normative and regulative. The analysis of those semantic, organiza- tional, and procedural loadings which carry out discursive practices inactivity of institutes of society is given. In particular, emphasis is placed on the complex structure of normativity em- bodied by the public institution. It should at least highlight the explicit normativity of the system of rules and regulations on the one hand, and the order of discourse created and maintained by this institution, on the other. Discourse corresponds to the normativity in its usability — as a real process of normalization of life. Normativity exists only by generating certain practices of speech, communication, and argumentation (conclusion). This becomes the basis for distin- guishing the concept of an institution as a discursive mode of existence of a social institution on the one hand, and as a way of organizing discourse in society (order of discourse) — on the other. Among the main social effects of institutions are the generation of trust as the basis of social relations and the longevity of cultural experience. Emphasis is placed on the complexity of the existence and activities of institutions: each institution is involved in the general discursive-com- municative field of society, and in turn, influences it.
The starting point and the correct order of the study in Albinus’ Prologue: a new solution
Authors: MATSKIV Vasyl
Published: August 2022

The article refers to a long-standing dispute over the relations between the two orders of study of Plato’s dialogues in the Prologue of Albinus (Ch. V and Ch. VI, respectively). The dominant solu- tions are identified: 1) the acceptance of the first curriculum as «for amateurs» and the second curriculum as «for professional platonists» (J. Freudenthal, O. Nüsser, J. Mansfeld); 2) the treat- ment of the first course as a short introduction to the second (B. Reis). On the grounds of the obvious weaknesses of both positions and the lack of textual evidence, a change of perspective is suggested. The author argues that there was no need to coordinate these curricula, since the second curriculum was the only one that Albinus promoted, and the first, which focused on a non-exist- ent «ideal student», served as a «model». In addition, the author proves that Albinus did not offer for study the entire Plato’s dialogues, but only seven of these dialogues in the 5 stages of the second curriculum.
The hermeneutics of nietzscheanism: an analysis of the diversity of interpretations of Friedrich Nietzsche's philosophy through the prism of the evolution of Ernst Jünger's ideas
Authors: PEREDRII Bohdan
Published: August 2022

The essence of Nietzscheanism as a philosophical doctrine has never been characterized by a definite consistency or certainty. Instead "indirect followers" and interpreters of Friedrich Nietzsche's philosophy (since this thinker did not have direct followers or a particular school) resorted to a variety of interpretations of his concepts. Considering that, the hermeneutic aspect of the study not only of Nietzsche's texts, but also of his interpreters allows us to look at the hidden potential of the concepts of the German philosopher from a new point of view. In this research, we seek to focus on looking for Nietzschean roots in Ernst Jünger's creative legacy, tracing the transformation of his ideas along the author's intellectual path and showing how those ideas correlate with those of Friedrich Nietzsche himself and how they differ. As a reference point for any study of interpretations of Nietzsche's philosophy, the author singles out many German philosopher concepts at the edge of various interpretations. Such central concepts in the article include the idea of "Apollonian" and "Dionysian" principles (the first), the anthropological idea of " Overhuman" and the interrelated metaphysical triad of "will to power," "reevaluation of all values," and "eternal return." In addition, one of the leading motives of the 20th century, which can be traced to an attempt to read Nietzschean ideas, postulates their location at the junction of philosophical and political-ideological concepts. Analyzing the peculiar hermeneutic conflict of Nietzschean philosophy based on this phenomenon, the author turns to early attempts to understand and implement the ideas of the German thinker, which were carried out directly in Germany. This context is connected in the article with the formation of the foundations of the conservative revolution and the figure of Ernst Jünger since the interpretation of this thinker, to some extent, can be considered one of the first and, undoubtedly, the most resonant. In the course of the research, the author turns to Nietzsche's original texts, forming a kind of hermeneutic circle of the author and interpreters, interpreters and the interpreted, ultimately obtaining in this system the opportunity for a thorough and as independent as possible analysis of the original ideas, counting on the probability of reducing the error of one's interpretation due to paying attention to the entire interpretive field texts The considered ideas of Ernst Jünger demonstrate this thesis, expanding the contextual field of the Nietzschean Overman and the metaphysics of the Will to Power and giving these concepts in an interpreted form a particular social dimension along with the philosophical one, which provides a new context for the interpretation of the ideas of Friedrich Nietzsche.
Some aspects about the prospects of the "National strategy for the development of artificial intelligence in Ukraine''
Authors:   Kryvyi Rih National University, A Kupin
Published: August 2022

The urgency and importance of the Ukrainian Artificial Intelligence Strategy creation is confirmed by the need to ensure the competitiveness of the national economy, security and defense of the state, the implementation of the latest research and technology development. This document clearly defines the directions of breakthrough technologies that can be implemented in Ukraine.
Manifestation of artificial intelligence in human life
Authors:   National Technical University of Ukraine «Igor Sikorsky Kyiv Polytechnic Institute», A Kasianenko , V Fedotov ,   National Technical University of Ukraine «Igor Sikorsky Kyiv Polytechnic Institute»
Published: August 2022

Today, in many areas of science and social life, machines, or so-called robots, are entrusted with tasks that previously could only be performed by humans, and this is what led to the creation of artificial intelligence and further stimulates its development and improvement. Automated machines, which are endowed with artificial intelligence, are thus able to relieve a person from routine activities, in particular. Thus, systems based on artificial intelligence are increasingly used in technology, for example, cars endowed with artificial intelligence, or, for example, robots involved in production. That is, the purpose of creating artificial intelligence is primarily to improve human life. However, any system has its shortcomings and problems that need to be explored for further improvement and effective development. It can be stated that scientists identify many problems in the field of artificial intelligence and this list is not exhaustive and with the development of society there will be other debatable issues, however, in my opinion the central problem is the lack of unambiguous opinion on scientific discourse. basic concepts, such as "thinking", "consciousness", "intelligence". And in view of the above, there is an urgent need for a common understanding of these concepts, so that in the future it is possible to qualitatively solve the already mentioned legal and moral problems in the field of artificial intelligence. A large number of domestic researchers are studying issues related to artificial intelligence and looking for ways to overcome problems or at least reduce the number of problems in this area. These include: Karchevsky MV Nikolskny, Yu. V., Pasichnyk VV, Shcherbyna Yu. M., Stefanchuk RO, Pozova DD ,. Radutny OE and others.
The system of personal early non-invasive diagnosis of cardiac conditions as an element of the cyber physical system
Authors:   Lviv Polytechnic National University, V Hrytsyk , I Danych ,   Lviv Polytechnic National University
Published: August 2022

In the 21st century, the most common cause of death in the developed countries is cardio. The Covid’19 pandemic only confirms this claim that the circulatory system and the heart are possible. That is why, even during a pandemic, the quality of cardio remains paramount. The significant cost of solving each element of these problems is the main driver of the idea of developing the ideology of preliminary diagnostics, as it allows you to more quickly (and therefore more effectively) respond to problems. In addition, today in Ukraine (and in the world as well) the cost of medical care is growing rapidly and not every society can afford to pay for medical services according to the usual rules of 20th century. One of the solutions that Ukraine is familiar with is that the pressure measurement is now done independently, and not an ambulance is called (doctor, nurse / brother, driver). The authors set themselves the task of exploring the following possibility in the problem of preliminary diagnostics to reduce the burden on the medical system. The aim of the work is to test the hypothesis of the possibility of early detection of cardio abnormalities by developing / creating an individual mobile device for preliminary diagnosis of the condition. In particular, on the example of monitoring the most common problem, rapid early diagnosis based on cardio signals. The main advantage of using the studied approach is the possibility of early diagnosis (rapid response) to complications, which is read by the sensor and analyzed by the analytical system (monitoring system). A basic study and experimentally tested the basic hypotheses are presented in the paper. The level and number of basic tasks that need to be solved to achieve the ultimate goal are checked. The basic concept of a personal intellectual advisor is tested. The results obtained during the experiments are visualized.
Intellectual decision-making technology in agricultural production
Authors:   Institute of Water Problems and Reclamation NAAS, Yu. Tararico , V Lukashuk ,   Institute of Water Problems and Reclamation NAAS
Published: August 2022

Objective assessment of agro-resource potential of regions, understanding of the principles of forming the optimal structure of production in relation to soil and climatic conditions and energy potential, analysis of factors influencing the use of certain means of production, allows producers to make close to optimal current and strategic decisions. To do this, all industrial resources must be considered not separately, but in a complex structure of the agricultural production system in order to ensure the most rational use of them in optimal quantities and interaction. To strengthen the food security and energy independence of the state, it is necessary to form a powerful agricultural sphere of Ukraine. This is achieved through the rational use of agricultural resources, including solar energy through the binding of virtually unlimited resources of nitrogen, carbon, oxygen and hydrogen of the Earth's atmosphere in fats, proteins and hydrocarbons, provided mandatory recycling or reuse of minerals, balanced combination of biological and industrial resources and systematic increase of soil fertility. Therefore, it is necessary to make the transition from the traditional style of enterprise management, based on the production experience and intuition of managers and staff, to modern methods of decision-making that allow for operational and long-term planning with high accuracy and predictability. It is known that the main tool of systems analysis is modeling. The fundamental value of the model lies in its ability to change the real process. For most farms, the farm-wide experimentation procedure is either unacceptable or impractical. Such an experiment has too dangerous consequences for them. Therefore, when analyzing the problem, there is a need for a simulator of the researched enterprise, which could be used for testing instead of the real system. Such a simulator is a model that should reflect the most important patterns of transformation of natural, material, financial, informational, energy and labor resources into agricultural products. The result is a system of interconnected standard modules for determining indicators: production volumes, product prices, the amount of costs, the amount of credit required, the assessment of possible profits and the accumulation of own funds. Each of the considered production or economic indicators can be determined separately. The algorithm of the perspective information system presented in the work allows to comprehensively analyze the action and interaction of individual components of agricultural production and to make close to optimal strategic and current decisions at different levels of agro-industrial complex management.
Architectural and mathematical fundamentals of improvement neural networks for classification of images
Authors:   Central Research Institute of Armaments and Military Equipment of Armed Forces  of Ukraine, V Slyusar
Published: August 2022

The article proposes ways to solve the problem of structural synthesis of neural networks architectures; based on non-traditional approaches to their analytical formalization and application of new ones data processing operations. The example of the CIFAR10 dataset proves the possibility of improving the accuracy of the solution image classification tasks within an alternative architecture with expandable input and narrowing structures of trained neural networks. The results of the application of input expanding image taken with Resizing and Conv2DTranspose layers at the input trained neural networks indicate the effectiveness of solving such classification problems by example CIFAR10 dataset. Achieved on the basis of the Xception neural network, the average classification accuracy of 10 classes CIFAR10 images are 97.3%. The side effect of pre-scaling images is leveling the accuracy of the classification of different classes, which allows us to consider such a change in size as an option data augmentation in the dataset. Tensor-matrix methods have been introduced for further development of this approach formalization of the description of neural networks on the basis of the penetrating end product of matrices and its block ones modifications. On this basis, a number of new convolution and maxpooling operations are proposed, as well as combinations on input of the narrowing segment not only symmetrically enlarged image, but also its variants obtained on the basis of a generalized penetrating product. It is about drawing images expanded by rows of pixels (horizontally) and columns (vertically), as well as a combination of several different options symmetrical image extensions on the principle of constructing a pyramidal segment of the PSPNet neural network.
Intelligent technologies in information retrieval systems
Authors:   National Technical University of Ukraine “Igor Sikorsky Kyiv Polytechnic Institute'', D Lande ,   World Data Center (WDC) for Geoinformatics and Sustainable Development,   Institute for Information Recording of the National Academy of Sciences of Ukraine, A Soboliev ,   National Technical University of Ukraine “Igor Sikorsky Kyiv Polytechnic Institute'',   World Data Center (WDC) for Geoinformatics and Sustainable Development,   Institute of Special Communications and Information Protection of the National Technical University of Ukraine “Igor Sikorsky Kyiv Polytechnic Institute'', O Dmytrenko ,   World Data Center (WDC) for Geoinformatics and Sustainable Development,   Institute for Information Recording of the National Academy of Sciences of Ukraine,   Institute of Artificial Intelligence Problems under MES of Ukraine and NAS of Ukraine
Published: August 2022

This paper considers the use of modern intelligent technologies in information retrieval systems. A general scheme for the implementation of Internet search engines is presented. The existing and prospective approaches to the intellectualization of individual components of this scheme are presented. An approach to the creation of a system of intelligent agents for information collection is presented. These agents are combined into teams and exchange the results of their work with each other. They form a reliable basis for the information base of search engines, ensure uninterrupted operation of the system in case of failure of individual agents. Methods for the formation of semantic networks corresponding to the texts of individual documents are also considered. These networks are considered as search patterns of documents for information retrieval and detection of duplicates or similar documents. Machine learning methods are used to conduct sentiment analysis. The paper describes an approach that made it possible to make the transition from the use of a naive Bayesian model to a modern machine learning system. The issues of cluster analysis and visualization of search results are also considered.