bluuebunny/crossref_metadata_2025 huggingface dataset:
Optimizing Machine Translation to Overcome Mechanical Engineering Vocational Education Students Difficulties in Academic Writing
Authors: Sulistyaningrum Siti Drivoka , Avianka Trisya
Published: November 2021

Background:

Machine translation has been proved to be a favourable style to execute. However, some research evidence difficulties indicates that its focus is on students' difficulties in academic writing, not on how to overcome them by using machine translation. As a result, this research aims to determine how machine translation might be optimized to help mechanical engineering vocational education students with academic writing difficulties.

Methodology:

The data was collected from 27 second-semester mechanical engineering vocational education students currently enrolled in an English college course at one of the Universities in Jakarta. Questionnaires online were used to obtain the data, which was analyzed and interpreted descriptively. Questionnaire 1 is used to determine whether or not the subject utilized machine translation and, if so, what type of machine translation they used most frequently. Question 2 was split into two sections. PART A was modified from Xiao & Chen (2015), who described students' challenges with academic writing. It comprises 12 items that were delivered to 27 students via Google Form. Meanwhile, the findings of Lee (2020) have been adapted into PART B.

Findings:

The result of this study revealed that 27 students of mechanical engineering vocational education in one of the Universities in Jakarta encountered several academic writing difficulties such as grammar (construct grammatically correct sentences, the use of appropriate tenses), expressions (discourse markers, part of speech), and vocabulary (proper vocabulary choices and finding synonyms). Grammar problems are the most challenging, followed by vocabulary and phrases. The optimization of machine translation was also discovered to be the most effective way of overcoming vocabulary issues followed by grammar and expression.

Conclusion:

Academic writing issues emerge in the classroom. According to the findings, the most difficulties students encountered fell into the grammar aspect. On the other hand, the students considered that machine translation would be the most helpful in overcoming their vocabulary challenges. Although machine translation helps deal with academic writing difficulties like developing vocabulary skills, increasing knowledge of grammar rules in context, and finding more authentic expression, teachers should also guide them in writing academically.

Keywords: optimizing machine translation; academic writing difficulties; grammar; vocabulary; expressions.
Text-Based Language Teaching in the New-Normal Era to Achieve Communicative Competence: Challenges for EFL Teachers
Authors: Rustipa Katharina , Yulistiyanti Yulistiyanti , Mulatsih Sri
Published: November 2021

Abstract

Background:

To live in this communicative era, people need to have communicative competence. The main aim of ELT is to enable the students to communicate or to produce a text. Thus, EFL teaching needs to facilitate them to achieve communicative competence so that they can participate actively in their communities. EFL teachers can utilize text-based teaching to realize this. Text-based teaching involves the use of texts, which are context bases for achieving communicative competence. This paper is a reflection, describing the teachers' common problems in implementing text-based teaching, especially under the COVID-19 pandemic.

Methodology:

This study is qualitative survey research to gain in-depth information about the topic of the study. The goal of this study is to describe the teachers' perception of Text-Based Approach in ELT and to describe their challenges to implement text-based online teaching. Open-ended survey questions were delivered to 15 research participants. To get a comprehensive understanding of the research participants' opinions, the researchers followed up their answers with an interview via a telephone call.

Findings:

The questionnaire, interview, and teachersâ€™ self-written reflection revealed the teachersâ€™ common problems in implementing text-based teaching, i.e. in selecting texts, in adapting or in modifying texts, in designing tasks, in overcoming studentsâ€™ boredom, besides the problems of online teaching.

Conclusion:

The main root of the problems is the teachers' lack of knowledge of text-based approach. Thus, updating the teachers' knowledge can be one of the solutions to the problems.
Disney Movie Soundtrack: Does It Give Effect to Studentsâ€™ Speaking Skill?
Authors: Permana Alda Indah , Megawati Fika
Published: November 2021

Background:

The implementation of media in the learning process can be a crucial thing to support studentsâ€™ competence. Meanwhile, teacher also has a role to utilize creative media in honing studentsâ€™ English skill especially in speaking. This study showed that the use of song media especially Disney movies soundtrack has a significant effect for eleventh grade studentsâ€™ speaking skill. However, there are several steps which should be done before applied the treatment.

Methodology:

This study used quasi-experimental with non-equivalent control group design. The object of this study was two classes which divided as experimental group and control group on the eleventh grade at Islamic boarding school. Furthermore, the data were collected from studentsâ€™ pre-test and post-test scores. The score of test in the experimental group showed the results based on the implementation of treatment using Disney movies soundtrack, while the control group only used conventional learning.

Findings:

The report of finding in this study revealed that there is a significant effect toward studentsâ€™ speaking skill after the researcher applied the use of English song especially Disney movies soundtrack as the media during the learning activities. Moreover, it also showed the difference between score of students in experimental group which increased than the results of studentsâ€™ scores in control group. In addition, the learners still have to practice their speaking skill in daily life.

Conclusion:

The effect of Disney movies soundtrack becomes an effective media for eleventh grade studentsâ€™ speaking skill at Islamic boarding school.

 

Keywords: Speaking Skill, English Song, Disney Song
N Sequence Prime Ideals
Authors: Ahmad Hemin A. , Hummadi Parween A.
Published: November 2021

In this paper, the concepts of -sequence prime ideal and -sequence quasi prime ideal are introduced. Some properties of such ideals are investigated. The relations between -sequence prime ideal and each of primary ideal, -prime ideal, quasi prime ideal, strongly irreducible ideal, and closed ideal, are studied. Also, the ideals of a principal ideal domain are classified into quasi prime ideals and -sequence quasi prime ideals.
Crecimiento postraumático en hombres gays con VIH en Buenos Aires, Argentina
Authors: Radusky Pablo David , Zalazar Virginia , Arístegui Inés
Published: November 2021

Este estudio cualitativo tuvo como objetivo explorar los significados atribuidos al virus de inmunodeficiencia humana (VIH) y la experiencia de cambios positivos posteriores al diagnóstico (crecimiento postraumático) en hombres gays de Buenos Aires, Argentina. Se efectuaron catorce entrevistas individuales en profundidad. Se implementó un análisis temático asignando códigos a fragmentos de transcripciones y organizándolos en temas. La edad media de los participantes fue de 41.29 (D.E.=11.97) y una media de 8.42 (D.E.=7.08) años desde el diagnóstico, tres de los cuales lo habían recibido en el último año. La mayoría informó cambios positivos que atribuyeron al diagnóstico de VIH, los que se organizaron en tres temas: Cambios en la filosofía de vida, Cambios en las relaciones con los otros y Cambios en la percepción de sí mismos. Algunos de estos incluyen mayor aprecio por la vida y su salud, incremento de comportamientos más saludables, fortalecimiento de la red de apoyo social y conciencia de sus capacidades para el afrontamiento. Tales cambios parecen asociarse a la atribución al VIH de sentidos más favorables. La identificación de crecimiento postraumático puede orientar intervenciones psicoterapéuticas y psicosociales dirigidas a hombres gays con VIH en virtud de que funciona como un recurso para afrontar el estigma y se asocia con una mayor retención en la atención del VIH.
Creencias sobre las drogas: diferencias según su consumo en adolescentes
Authors: Pérez Pedraza Bárbara de los Ángeles , Mendoza Trejo Carla , López Rodríguez Diana Isabel , Molina Coloma Verónica Alexandra
Published: November 2021

La adolescencia es una etapa vulnerable en la que se inicia en el consumo de drogas. El objetivo del presente estudio comparativo fue contrastar las creencias y actitudes que tienen los adolescentes sobre las drogas, cuyo consumo es nulo o moderado; así como aquellos que realizan un consumo abusivo de tabaco, alcohol y drogas ilegales. Mediante un muestreo por conveniencia, se seleccionó a 50 participantes que reportaron un abuso de drogas, y otra de 51 participantes que afirmaron tener un consumo nulo o moderado, a los que se les aplicó el Cuestionario sobre Percepción de Riesgo de los Adolescentes hacia el Consumo de Drogas Legales e Ilegales. Los resultados indican que quienes se exceden en las drogas puntuaron más alto en creencias tales como que consumir bebidas alcohólicas ayuda a pasarla bien y provoca problemas escolares y laborales, comparados con los de los adolescentes con un consumo nulo o moderado. Se destaca la importancia de llevar a cabo intervenciones para la desnaturalización del uso de las drogas, de manera que los adolescentes comprendan cuándo su uso se convierte en abuso.
Determinação de umidade em madeira de hymenaea courbaril L exposta a diferentes condições de armazenamento
Authors: De Moura Ingrid Rebouças , Silva Geovanne Lopes Cruz da , De Almeida José Carlos Gomes , Costa Emerson Bruno da , Souza Wendell Rossine Medeiros de , Viana Herbert Ricardo Garcia
Published: November 2021

A secagem da madeira é um processo extremamente importante para aferir a qualidade do produto madeireiro. Esse processo, quando realizado corretamente garante a continuidade de suas características, mesmo quando exposta a condições adversas do meio ambiente. Nesse sentido, o presente artigo tem como objetivo determinar a umidade da espécie Jatobá em duas madeireiras do município de Angicos/RN, que possuem distintas formas de armazenamento da madeira, afim de identificar como as madeiras estão sendo comercializadas e até que ponto o clima pode influenciar nos valores de umidade ao longo da peça. Assim, retirou-se uma amostra de cada estabelecimento e foram confeccionados seis corpos de prova, com dimensões de 2,0 cm x 3,0 cm x 5,0 cm ao longo das fibras, como exigido pela NBR 7190/97 - Projeto de estruturas de madeira. Os ensaios foram realizados com aparelho de medição de umidade (MD 814) e pelo método de pesagem. Nas análises realizadas, observou-se pelo aparelho de medição, a instabilidade das peças quanto a umidade em ambas as madeireiras, e que a madeira pode ser superficialmente afetada pelo clima, porém conservar suas propriedades internamente.
Atividade Enzimática de Fungos Presentes em Caules de Árvores Frutíferas do Cerrado Goiano
Authors: Barbosa Isabel Thayse , Abrão Flávia Oliveira , Fernandes da Silva Talyta Priscila Gonçalves , Silva Thiago Dias , E Silva Daniara Rayane , Pessoa Moisés Sena
Published: November 2021

O objetivo com esse estudo foi avaliar as atividades proteolítica e pectinolítica de isolados fúngicos oriundos do caule de seis árvores frutíferas: pequizeiro, mangabeira, lobeira, muricizeiro, pimenta de macaco e marmelada. Submeteu-se 18 cepas fúngicas, em triplicata, a ensaio enzimático conforme as metodologias adaptadas de Strauss et al. (2001) e Brizzio et al. (2007), em distintos períodos (24, 48 e 72 horas). Para tratamento dos dados, utilizou-se o delineamento inteiramente ao acaso e aplicaram-se testes não paramétricos, Friedman (α= 5%) (efeito dos períodos de incubação) e Kruskal-Wallis (α= 5%) (fonte do substrato). Os isolados fúngicos apresentaram maior índice de atividade pectinolítica às 24 e 48 horas de incubação (P<0,05). As cepas epifíticas em meio caseína tiveram índice de atividade enzimática superior (P<0,01). No tocante à planta nativa, os isolados da marmelada tiveram maior índice enzimático no respectivo meio, enquanto os das cepas oriundas da lobeira, mangabeira e pequizeiro apresentaram baixos índices (P<0,01). Todos os isolados fúngicos apresentaram atividade enzimática relevante, em destaque, as cepas do gênero Malbranchea spp. obtiveram maior índice de atividade proteolítica (P<0,01) e pectinolítica, em conjunto com Aspergillus spp. e Aureobasidium spp. (P<0,05). Dessa forma, conclui-se que os isolados fúngicos do Cerrado possuem potencial enzimático. Como o gênero Malbranchea spp. apresentou maiores índices de atividade proteolítica, é o mais indicado para realização de futuros testes enzimáticos objetivando a aplicação das enzimas. Quanto aos outros isolados, sugere-se que novas pesquisas sejam realizadas com intuito de analisar condições ótimas para produção de proteases e pectinases.
Negative Impoliteness and Reconstruction of Identity: Cyberpragmatics Analysis of Palestinian Conflict News Comments on Arab Youtube Channel
Authors: Faisol Yufni , Rahmat Wahyudi
Published: November 2021

This study aims to explain the negative impoliteness in the comments on the news of the Palestinian conflict on the Arab Youtube channel. This descriptive qualitative research took the source of data in the form of 5 news of the attack on the Al-Aqsa mosque complex by the Israeli military on the Al Jazeera youtube channel as a data source. The internet archive documentation technique and free-of-conversation listening technique were used at the data collection stage. Meanwhile, the identity method by referring to the stages of qualitative analysis was used as a guide in data analysis. The researchers found 310 negative impoliteness speeches consisting of 5 types: frighten found at 17 speeches (6%); condescend, scorn or ridicule at 113 speeches (36%); invade the other’s space at 72 speeches (23%); explicitly associate the others with negative aspect at 97 speeches (31%); put the other’s indebtedness on record at 11 speeches (4%). The negative impoliteness has a context in the form of criticism of the political policies of Arab countries in responding to the Palestinian conflict. Speakers seek to construct a new community identity for Arab countries in the context of fighting against the Israeli occupation of Palestine.
Influência da assistência à saúde ofertada ao paciente surdo: uma revisão de literatura
Authors: Inácio Eclair Graciano , Gómez Luís Fernando Borja , Cruz Ynez Lopes de Souza , Nascimento Natanael da Silva , Ribeiro Lucas Oliveira , Queiroz João Gabriel Gomes , Fortes Octávio Augusto Cavalcante , Ferreira Romão de Carvalho , Sinhorin Gustavo Henrique
Published: November 2021

Objetivos: Analisar e avaliar o impacto da assistência à saúde ofertada ao paciente surdo. Métodos: Trata-se de uma revisão integrativa de literatura, cujo levantamento de informações foi realizado em banco de dados eletrônicos: Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS), Medical Literature Analysis and Retrieval System Online (MEDLINE), Scientific Eletronic Library Online (SciELO) e PubMed. Em relação a critério de inclusão, foram selecionados os artigos dos últimos 10 anos. Em relação a critério de exclusão, foram desconsiderados artigos que não abordaram o tema proposto. Resultados: Essa revisão literária está composta por 11 artigos que trazem informações referente sobre profissional de saúde e paciente, com percepções do atendimento de ambos os lados. Considerações finais: Sugere-se que os surdos possuem maior tendência a adoecer com maior facilidade em relação à população ouvinte. Outro fator que corrobora é a comunicação prejudicada entre paciente e médico, que reduz entendimento sobre prevenção, diagnóstico e tratamento.
Multinucleate Cell Angiohistiocytoma: A Case Report and Unique Treatment Consideration
Authors: Karim Maria , Wu Marlyn , Ros Adriana
Published: November 2021

Introduction:  Multinucleate cell angiohistiocytoma (MCAH) is a benign, yet exceedingly rare vascular and firbiohistiocytic proliferation. The lesions are typically asymptomatic and are commonly cosmetically displeasing to patients. 1 Previous reports have demonstrated success in treating MCAH with fractional ablative CO2 laser, argon laser, pulsed dye laser, and KTP lasers. 3 The scarcity of reported cases may suggest that the lesion is commonly misdiagnosed, and we report this case to highlight the characteristic features of MCAH with successful treatment with Neodymium YAG laser.

Case Presentation: A 64-year- old female presented to our clinic with a 1- month history of multiple erythematous to violaceous lesions on her bilateral hands. The lesions were asymptomatic, but cosmetically displeasing for the patient. Past medical history and family history was noncontributory. Examination revealed several 2-6 mm well- circumscribed, erythematous, indurated smooth papules on the bilateral dorsal and in the second web space of the left hand. Shave biopsy of the lesions were consistent with MCAH. She was initially treated with topical steroids twice daily for 2 weeks, with no improvement. The patient received 3 treatments with Neodymium YAG, 4 weeks apart. This treatment was discontinued after 3 sessions due to the dramatic visible improvements in regards to induration and discoloration of the lesions.

Discussion: MCAH is an extremely uncommon lesion, diagnosis is made on the basis of clinical examination, histopathologic and immunohistochemical analysis of the lesions. This case illustrates diagnosis and successful treatment of MCAH with Neodymium YAG and offers a unique treatment consideration for patients.
Successful Use of Apremilast in Psoriasiform Dermatitis Refractory to Biologics
Authors: Yang Christopher , Quan Victor , Amin Ahmad
Published: November 2021

Psoriasis is a common immune-mediated genetic disease that can affect the skin, nails, and joints. Management is usually comprised of topical therapy and/or systemic therapy, either biologic or nonbiologic. This case shows a psoriasiform dermatitis with primary response failure to several systemic biologic and nonbiologic therapies for atopic dermatitis (methotrexate, dupilumab) and psoriasis (cyclosporine, adalimumab, ustekinumab, guselkumab, ixekizumab). Ultimately, the patient was treated successfully with apremilast. This case suggests that certain cases of psoriasis may improve exclusively with PDE-4 inhibition. Conversely, this could also suggest existence of a separate entity of psoriasiform dermatitis that is primarily mediated by PDE-4. We encourage a trial of apremilast in patients presenting with disease mimicking psoriasis who fail multiple therapies.
Melanoma Recurrence after Mohs Micrographic Surgery with MART-1: A Systematic Review and Meta-analysis
Authors: Long Tyler , Dunn Austin , Arndt Mary , Parlette Eric
Published: November 2021

Background: Surveys suggest wide-spread use of MART-1 in MMS for CM among Mohs surgeons, but no previous systematic review has investigated the efficacy of this specific procedure.
Methods: A systematic search and meta-analysis of retrospective studies on MMS with MART-1 was performed from Pubmed, Medline, and Cochrane databases for articles published from their inception to October 30, 2020. We performed a chi-squared analysis of homogenized data to examine the relationship between recurrence location and rate of recurrence. A risk of bias was obtained with the ROBINS-I tool. [PROSPERO ID: CRD42020221826]
Results: Among the included studies, there were a total of 15 (0.52%) local recurrences of melanoma in-situ and invasive melanoma after MMS with MART-1.
Conclusions: This review has served to demonstrate that MMS with MART-1 immunostaining in frozen sections is a technique that produces satisfactory recurrence rates for melanoma in-situ and invasive melanoma.
A Machine Learning-Based Test for Predicting Response to Psoriasis Biologics
Authors: Bagel Jerry , Wang Yipeng , Montgomery, III Paul , Abaya Christian , Andrade Eric , Boyce Courtney , Tomich Tatiana , Lee Byung-In , Pariser David , Menter Alan , Dickerson Tobin
Published: November 2021

Objective: This study was designed to develop and prospectively validate a machine learning based algorithm that could predict patient response to the most common biologic drug classes used in the management of psoriasis patients. This type of tool would allow clinicians to have greater confidence that a given patient will respond to a specific drug class, which could lead to improved health outcomes and reduced wasted healthcare spend.

Methods: Patients were enrolled into one of two observational studies (STAMP studies) where dermal biomarker patches (DBPs) were applied at baseline prior to drug exposure, followed by clinical evaluations at 12 weeks after exposure. PASI measurements were made at baseline and 12 weeks to evaluate clinical response to a clinical phenotype. Responders were defined as those who reached PASI75 at 12 weeks. The transcriptomes obtained from the DBPs were sequenced and analyzed to derive and/or validate classifiers for each biologic class, which were then combined to yield predictive responses for all three biologic drug classes (IL-23i, IL-17i, and TNFai).

Results: A total of 242 psoriasis patients were enrolled in these studies, including 118 patients (49.6%) treated with IL-23i, 79 patients (33.2%) treated with IL-17i, 35 patients (14.7%) treated with TNFai, and 6 patients (2.5%) treated with IL-12/23i. The IL-23i predictive classifier was developed from the earlier enrolled patients and independently validated with the latter enrolled patients. IL-17i and TNFai predictive classifiers were developed using publicly available datasets and independently validated with patients from the STAMP studies. In the independent validation, positive predictive values for three classifiers (IL-23i, IL-17i, and TNFai) were 93.1%, 92.3% and 85.7% respectively. Over the entire cohort, 99.5% of patients were predicted to respond to at least one drug class.

Conclusion: This study demonstrates the power of using baseline dermal biomarkers and machine learning methods as applied to the prediction of psoriasis biologic prior to drug exposure. Using this test, patients, physicians, and the health care system all can benefit in distinct ways. Precision medicine can be realized for individual patients as most will likely respond to their prescribed biologic the first time. Physicians can prescribe these drugs with increased confidence, and the healthcare system will realize lower net costs as well as greatly reduced wasted spend by significantly improving initial response rates to expensive biologic therapeutics.
A Phase 3, Randomized, Double-Blind, Vehicle-Controlled, Multicenter, Parallel Group Trial Investigating the Efficacy and Safety of Clobetasol Propionate Cream, 0.025% in the Treatment of Moderate to Severe Plaque Psoriasis for 14 Days
Authors: Desai Seemal , Draelos Zoe , Feldman Steve , Jackson J. Mark
Published: November 2021

N/A
Tapinarof Cream 1% Once Daily for Plaque Psoriasis: Long-Term Extension Trial of a Novel Therapeutic Aryl Hydrocarbon Receptor Modulating Agent
Authors: Strober Bruce , Stein Gold Linda , Bissonnette Robert , Armstrong April , Blauvelt Andrew , Brown Philip , Kircik Leon , Tallman Anna , Lebwohl Mark
Published: November 2021

N/A
A randomized, investigator-blinded study to compare the efficacy and tolerance of a 650-microsecond, 1064-nm YAG laser to a 308-nm excimer laser for the treatment of mild-to-moderate psoriasis vulgaris
Authors: Nestor Mark , Fischer Daniel , Arnold David , Han Haowei , Gade Anita , Ceci Francesca , Dunn Austin , Lawson Alec
Published: November 2021

N/A
Roflumilast Cream 0.3% Improved the Severity and Impact of Itch in Patients With Chronic Plaque Psoriasis in the Phase 3 DERMIS-1 and DERMIS-2 Studies
Authors: Gooderham Melinda , Alonso-Llamazares Javier , Bagel Jerry , Browning John , Draelos Zoe , Grande Kimberly , Herbert Adelaide , Jing Loo Wei , Hong Chih-ho , Lebwohl Mark , Nahm Walter , Papp Kim , Pariser David , Soung Jennifer , Stein Gold Linda , Turchin Irina , Feng Amy , Burnett Patrick , Higham Robert , Berk David
Published: November 2021

N/A
A Dermal Biomarker Patch Displays Excellent Analytical Performance and Outperforms Tape Stripping in Psoriatic Skin
Authors: Dickerson Tobin , Boyd Stephen , Andrade Eric , Abaya Christian , Wang Yipeng , Lee Byung-In
Published: November 2021

N/A
Mind.Px – Personalized Medicine for Psoriasis Biologic Treatment
Authors: Dickerson Tobin , Lee Byung-In , Montgomery Paul , Boyd Stephen , Andrade Eric , Boyce Courtney , Tomich Tatiana , Wang Yipeng
Published: November 2021

N/A
Phase IV Evaluation of the Adrenal Suppression Potential and PKPD of Halobetasol Propionate Foam, 0.05% in Adolescent Subjects with Plaque Psoriasis
Authors: Herbert Adelaide , Schreiber Rhonda , Glaab Debbie , Eichenfeld Lawrence
Published: November 2021

N/A
Retreatment With Brodalumab Results in Skin Clearance and Improvements in Quality of Life in Patients With Psoriasis After Treatment Interruption
Authors: Armstrong April , Keegan Brian , Han George , Jacobson Abby
Published: November 2021

N/A
Bimekizumab versus secukinumab efficacy across subgroups of patients with moderate to severe plaque psoriasis: Results from the multicenter, randomized, double-blinded phase 3b BE RADIANT trial
Authors: Blauvelt Andrew , Iversen Lars , McBride Sandy , Gooderham Melinda , Staubach Petra , Yamauchi Paul , Staelens Fabienne , Vanoorden Veerle , White Katy , Gisondi Paolo
Published: November 2021

N/A
Itch-Free State in Patients With Atopic Dermatitis Treated With Ruxolitinib Cream
Authors: Blauvelt Andrew , Szepietowski Jacek , Papp Kim , Simpson Eric , Silverberg Jonathan , Kim Brian , Kwatra Shawn , Kuligowski Michael , Venturanza May , Sun Kang , Kircik Leon
Published: November 2021

N/A
Long-term Safety and Efficacy of Difelikefalin in Subjects With Chronic Kidney Disease–Associated Pruritus: Analysis From KALM-1 and KALM-2
Authors: Fishbane Steve , Wen Warren , Munera Catherine , Menzaghi Frédérique , McCafferty Kieran
Published: November 2021

N/A
Efficacy of Difelikefalin in Subjects With Moderate-to-Severe Chronic Kidney Disease–Associated Pruritus: Pooled Subgroup Analysis of KALM-1 and KALM-2
Authors: Topf Joel , Wen Warren , Munera Catherine , Menzaghi Frédérique , Schömig Michael
Published: November 2021

N/A
Enhanced Uptake of 10% Ascorbic Acid After 1440-nm or 1927-nm Non-ablative Fractional Diode Laser Treatment
Authors: Wang Jordan , Friedman Paul , Konda Adarsh , Parker Catherine , Geronemus Roy
Published: November 2021

N/A
Quantifying Uptake of Topical 4% Hydroquinone After 1440-nm and 1927-nm Non-ablative Fractional Diode Laser Treatment
Authors: Wang Jordan , Friedman Paul , Konda Adarsh , Parker Catherine , Geronemus Roy
Published: November 2021

N/A
A Randomized, Double-blind, Vehicle-Controlled Phase 2a Study Evaluating Once Daily Roflumilast Foam 0.3% in Patients With Moderate to Severe Seborrheic Dermatitis
Authors: Zirwas Matthew , Draelos Zoe , Dubois Janet , Kircik Leon , Moore Angela , Stein Gold Linda , Alonso-Llamazares Javier , Bukhalo Michael , Bruce Suzanne , Eads Kimmie , Green Lawrence , Guenthner Scott , Ferris Laura , Forman Seth , Kempers Steven , Lain Edward , Lynde Charles , Pariser David , Pariser David , Toth Darryl , Yamauchi Paul , Burnett Patrick , Berk David
Published: November 2021

N/A
The Importance of Poverty in Sustainability Policies: An Approach to Understanding Online Opinion
Authors: Del-Pino Miguel A , Bodaghi Arezo , Watine Pierre , Schmitt Ketra
Published: November 2021

Twitter data related to poverty and basic income was collected for 24 days in 2019, and then was cleaned and prepared for natural language processing. A 7 % subset of the data was manually labeled for sentiment analysis in order to inform the artificial intelligence (AI), which was trained and verified on this subset. We present the results for both the 7 % verification sample and the entire database. This analysis of public opinion on poverty is situated within the Sustainable Development Goals and the support for poverty reduction policies.
Casos de éxito en la implementación del mantenimiento predictivo mediante el uso de tecnologías de la industria 4.0 en empresas colombianas
Authors: Dueñas-Ramírez Leidy Marcela , Villegas-López Gustavo Adolfo , Castiblanco-Tique Sebastián , Castaño-Restrepo Carlos Andrés
Published: November 2021

Con la llegada de nuevas tecnologías el mantenimiento ha dado pasos sustanciales en estas últimas décadas, dejando de lado la toma de datos manuales. Se han adoptado sistemas automatizados y computarizados más eficientes y confiables, técnicas de inspección predictivas y sistemas de control en tiempo real a distancia. Esto ha permitido a las empresas desarro llar planes específicos de mantenimiento a partir del análisis del flujo de datos recolectado, generando beneficios en términos de tiempo y costo. Este artículo expondrá los resultados obtenidos por dos empresas colombianas de gran relevancia en el país en la implementación de tecnologías de la industria 4.0 en los procesos de mantenimiento predictivo. Se hizo un análisis de sus condiciones de éxito y cómo esta metodología ha impulsado su reconocimiento y presti gio en sus respectivos sectores de la industria. Todo este proceso de investigación se lleva a cabo mediante el uso de herramientas y escenarios virtuales, dada la contingencia del COVID-19.
Evaluación de un sistema wifi híbrido para la ubicación en interiores mediante la intensidad de la señal (RSSI) y la trilateración entre dispositivos IoT
Authors: Millones-Fache Piero Angello
Published: November 2021

La presente investigación abarcó la problemática del GPS, la cual es hallar el posicionamiento en entornos de interiores mediante redes inalámbricas. Se emplearon diversas técnicas como path-loss, trilateración, RSSI, regresión lineal, smoothing filter. Finalmente, se consiguió un sistema híbrido capaz de obtener la posición de un objeto con base en las posiciones de los sensores que se estén utilizando.
Polymorphic variants of glutathione reductase – new genetic markers of predisposition to type 2 diabetes mellitus
Authors: Azarova Iuliia E. , Klyosova Elena Yu. , Polonikov Alexey V.
Published: November 2021

Aim. To study the associations of three common single nucleotide variants of the gene encoding antioxidant system enzyme, glutathione reductase GSR with a predisposition to type 2 diabetes (T2D).
Materials and methods. The observational mono-center transverse controlled study involved 1032 type 2 diabetics (640 women, 392 men; mean age 61.14.8 years) and 1056 healthy volunteers (676 women, 380 men; mean age 60.96.2 years). Eating habits were evaluated retrospectively according to questionnaire data. A 10 ml blood sample was drawn from all participants in the study for genetic and biochemical tests. Genotyping was done with the use of the iPLEX technology on MassArray System.
Results. We first identified the relationship of the polymorphisms rs2551715, rs2911678, rs3757918 of the GSR gene with a reduced risk of developing T2D in the Russian population. At the same time, the protective effects of the variants of the glutathione reductase gene manifested only in individuals with normal body weight provided they consumed fresh vegetables and fruits, whereas in those with insufficient consumption of plant foods, as well as in all overweight and obese patients, the protective effect of GSR was not observed. In patients with T2D, the plasma levels of hydrogen peroxide and the glutathione dimer were sharply increased compared with the controls. We also found that the rs2551715 polymorphism was associated with a lower concentration of hydrogen peroxide in the blood plasma of patients with T2D, while SNP rs2911678 was associated with a decrease in the concentration of the oxidized form of glutathione. Bioinformatical analysis confirmed the positive effect of alternative alleles on GSR expression and revealed the closest protein partners of the enzyme and their joint participation in the metabolism of acetyl-CoA, the catabolism of hydrogen peroxide and the control of cellular redox homeostasis.
Conclusion. Polymorphic variants of the GSR gene rs2551715, rs2911678, rs3757918 are associated with a predisposition to T2D, but their relationship with the disease is modulated by the consumption of fresh vegetables and fruits and depends on body mass index.
Type 2 diabetes and cognitive functions in patients with chronic cerebrovascular diseases
Authors: Tanashyan Marine M. , Surkova Elena V. , Antonova Kseniia V. , Lagoda Olga V. , Naminov Alexander V. , Berdnikovich Elena S. , Fedin Pavel A. , Titkova Irina I.
Published: November 2021

Background. Type 2 diabetes (Т2DM) both directly and indirectly impacts the development of morphological and functional changes of the central nervous system.
Aim. The study was to determine clinical and neurophysiological patterns of cognitive impairment (CI) in patients with chronic cerebrovascular diseases (CCD) and Т2DM.
Materials and methods. We examined 132 patients with CCD. First group included 58 patients without Т2DM aged 64.5 [58; 72], second group 74 patients with CCD and Т2DM 63 [57; 70]. Clinical, neurological, neuropsychological, neurophysiological (cognitive evoked potentials (EP) and neurovisualisation (brain MRI) examination was carried out to all patients.
Results. Somatic and neurological characteristics of the patients were similar in both groups with the exception of more distinct metabolic changes in Т2DM patients. Neurovisualisation study of the brain MRI in Т2DM patients revealed more distinct changes in the form of white matter hyperintensity and subarachnoidal spaces enlargement. Neuropsychological examination in patients revealed the reduction of intellectual flexibility, constructive praxis disruption, optical spatial dysfunction and deteoration of delayed word recall. Significant disorders in the way of overall cognitive impairment, lobar dysfunction and impaired verbal associative productivity, proved by statistically lower amplitude and higher latency of P300 EP peak were noted in Т2DM patients. Correlation links were detected: for P300 amplitude and direct and inverse number listing test (r=0.366 and r=0.520; p=0.006 and p0.001 respectively); P300 latency and HbA1c (r=0.32; р0.05) in group 2 and glucose levels in both groups (r=0.30; p0.05); inverse relationship of latency with control functions evaluation (r=-0.34; p=0.008).
Conclusion. CCD especially with Т2DM manifests with neurocognitive imbalance, including control functions disruption and are accompanied by neurophysiological and neurovisualistion changes.
Modern problems of hyper- and hypoparathyroidism
Authors: Mokrysheva Natalia G. , Eremkina Anna K. , Kovaleva Elena V. , Krupinova Julia A. , Vikulova Olga K.
Published: November 2021

The parathyroid glands are the most important regulators of mineral metabolism. The parathyroid glands were first discovered only in 1880 and their function went the long way unrecognized. Even the term "parathyroid gland" itself speaks of the initial misconception of it as an underdeveloped part of the thyroid. To date, there is a large amount of data regarding the role of this endocrine gland in the human body and the significant changes associated with their dysfunction, including such widespread diseases such primary, secondary and tertiary hyperparathyroidism, hypoparathyroidism. This review covers the problem of the main disturbances in calcium-phosphorus metabolism, presents the results of databases of patients with primary hyperparathyroidism and hypoparathyroidism, as well as current epidemiological trends in Russia and in the world.
PRODUCTION AND MARKETING SYSTEM OF FISH IN DHANUSHA, NEPAL
Authors: Koirala Shilpa , Jha Dilip Kumar , Lamsal Abishek , Adhikari Ansu
Published: November 2021

Aquaculture is an important agriculture sector in Dhanusha district with the involvement of large number of farming community. An interview-based questionnaire survey of 45 randomly selected fish farmers and 13 fish traders in fish block area of Dhanusha district, Nepal was carried out to appraise current situation of Production and marketing system of fish farming during the period of February to April, 2020. Majority of the farmers (86.76%) had done fish farming as main occupation and was found to be profitable with the average productivity of 5.53 Mt/ha/year and B/C ratio of 1.37. Most of the farmers were practicing carp polyculture however, monoculture and integrated fish farming was also found to be done by few respondents. Fish produced were sold in local market, adjacent districts and also to distant markets. The findings showed that traders were involved in marketing system of fish of which 59.65% of the total was sold to the wholesalers, 30.49% to the retailers and 9.87% was sold directly to the consumers. Commonly used means of transportation were bicycle, motorbike and pickup vans. The study also revealed that farmers were facing several problems like lack of technical knowhow, untimely availability of feed and other inputs, disease and water quality problem, lack of well managed commodity market, poor storage facilities etc. which needs to be addressed to enhance the fish production and marketing efficiency in the study area.
A REVIEW ON NON-CHEMICAL WEED MANAGEMENT IN MAIZE (ZEA MAYS L.)
Authors: Duwadi A. , Acharya A. , Gautam S.
Published: November 2021

Weed is omnipresent species that compete with major crops for light, nutrients, space, and water for their growth and development and ultimately deteriorate the ideal environment for crops growth. In the present context, herbicide application is the easiest and seemingly economical approach for weed control in south-Asian countries. In contrary, the side effects of herbicide on health and environment impose to adopt for the non-chemical method of weed management. This paper reviewed the menace of herbicide, crop weed association, the critical period of crop-weed competition, and different methods of organic weed control implemented especially for maize. The main objective of this review is to maneuver a weed control strategy for maize other than the chemical application. The findings of different research suggested that a critical period of crop-weed competition in maize lies between 2 to 8 weeks after crop sowing. Many mechanical methods for weed control in maize proved efficient but seemed labour intensive and biological methods provided maximum security against specific weed species. The cultural method in combination with other methods effectively reduced the weed population in the maize field. It was found that, if various components of non-chemical weed management are implemented systematically, we can control the weed population with higher economic return and achieve the goal of organic food production with sustainable solutions. Weed control in the organic system focuses on management techniques designed to prevent weed emergence, give a competitive advantage to the main crop, and act for sustainable solutions. The non-chemical integrated weed management system is recommended to reduce the use of herbicide and for sustainable production. A review of non-chemical weed management in maize could be helpful for researchers to provide useful, sustainable, and environmentally friendly solutions to farmers to solve the problem of weed infestation in the maize crop along with substantial yield improvement.
REVIEW ON PROSPECT OF GENETICALLY MODIFIED DIET IN OVERCOMING CELIAC DISEASE
Authors: Kayastha Preeti , Magar Radhika Gharti , Adhikari Yamuna , Koirala Prabesh
Published: November 2021

The advancements on biotechnological techniques and improvement in genetic makeup of plant cell structure gave rise to the genetic modification of plants in the 1980s. Genetically Modified plants have been a key to combat various diseases, Celiac Disease (CD) being one of them. Gluten, the structural protein of wheat, is identified as the prime cause of the autoimmune CD. Gluten-Free Diet (GFD) has been the only appropriate solution so far. In this review, we aim to shed some light on the numerous health implications caused by CD along with the merits and demerits of gluten-free diet. The inclination towards GFD is increasing even among non-celiac individuals. But GFD is considered inferior to products containing gluten though its claim to lessening gluten-related disorders and nutritional imbalance is pretty strong. The strict long term restriction to gluten is challenging to achieve, hence leading patients to seek for alternatives, possibly some manipulations in a genetic level that would create downregulation of the genes causing CD, while maintaining the nutrition, quality, and taste of the food. Approaches such as RNAi, EMS, Gene editing, Peptidase treatment, Gamma irradiation, and Deletion lines have shown convincing results in silencing the immunogenic epitope of gluten. This paper focuses on discussing various approaches on solving the issue of CD along with the prospects and challenges on obtaining a genetically modified diet against the disease. It highlights various biotechnological advances in obtaining such genetically modified diet as a promising guide to overcome Celiac Disease.
NON-GENETIC FACTORS AFFECTING GROWTH PERFORMANCE OF INDIGENOUS CHICKEN BREEDS IN NEPAL
Authors: Sah Rajan , Yadav Roshan Kumar
Published: November 2021

There are three identified indigenous poultry breeds in Nepal; Sakini, Ghanti Khuile, Pwankh Ulte. They are reared for dual purpose i.e. meat & egg. To access various non-genetic factors affecting growth performance of indigenous chicken, different relevant research papers, review papers, annual progress reports, and statistical year book were reviewed & analyzed. Results revealed that local breeds are hardy & subject to be affected with environmental factors. They are reared on natural food than formulated feed which meant that they were hardy & rich in high quality protein. They had better weight as they found food continuously in free ranging system. It was found that chicken reared in cool climate had higher body weight than the ones grown in hot period due to less respiratory loss & low body maintenance required. Natural daylight supplemented light at night time was being deployed by farmers & had satisfactory performance. Due to well-developed thick feathers on their body, indigenous chicken were deployed for brooding than artificial methods. Body weight and feed intake was found higher when floor space of 0.279/m2 per bird and flock size of 30 chickens were maintained. Despite any vaccinations, the indigenous breeds still had minimum disease incidence which may be linked to their better adaptability.
EFFECT OF DIFFERENT LEVEL OF WHEAT WITH AND WITHOUT PHYTASE ON FEED INTAKE, GROWTH PERFORMANCE, FEED EFFICIENCY AND ECONOMICS IN COBB 500 BROILERS
Authors: Sapkota Madan Mani , Tiwari Ishwor Chandra Prakash , Gyawali Nisha , Lamichhane Utsav
Published: November 2021

A study was conducted from 15th December 2019 to 25th January 2020 at Birendranagar Municipality- 12, Surkhet to determine the effect of phytase on the feed intake, growth performance and economics in cobb 500 broilers. Combined brooding was done for 10 days and then the chicks were separated into different treatments. A total of 288 broiler chicks were allocated to six different treatment groups. The experimental design was Completely Randomized Design (CRD), each treatment with four replications. And each replication had 12 birds in it. The birds in six treatments were fed with isoproteinous and isocaloric diet containing different level of phytase and wheat. T0 was the control diet containing basal diet, T1 consisted of basal diet and phytase (0.75gm/100 kg feed), T2 consisted of basal diet containing wheat (13%), T3 consisted of basal diet containing wheat (13%) and phytase (0.75gm/100 kg feed), T4 consisted of basal diet containing wheat (26%), T5 consisted of basal diet containing wheat (26%) and phytase (0.75gm/100 kg feed). Weekly average body weight, weight gain, feed consumption and feed efficiency were recorded for four weeks after the birds were allocated to different treatments. All the data recorded was statistically analyzed for Completely Randomized Design (CRD). The result showed that the overall weekly feed consumption was recorded higher (1.30 ± 0.0423 Kg) in the birds of treatment group T5. On the other significantly (P<0.01) higher (2688.46 ± 7.99 gm) cumulative live weight was recorded for the birds of treatment group T3. Likewise mean weekly weight gain was significantly (P<0.01) higher (293.53 ± 21.85 gm/week/bird) in treatment group T3 in the 1st week, significantly (P<0.05) higher (548.57 ± 4.06 gm/week/bird) in T1 in 2nd week, significantly (P<0.01) higher (649.23 ± 21.32 gm/week/bird) in T3 in 3rd week and significantly (P<0.01) higher (1122.65 ± 30.90 gm/week/bird) in T0 in 4th week. The overall FCR was significantly (P<0.01) better (1.94 ± 0.075) in the birds of treatment group T3. The benefit cost ratio was found to be highest (1.3916) from the birds in the treatment group T3. From the results of the experimental trial, it can be concluded that feed used in treatment group T3 helped in better performance and higher benefit cost ratio. Thus, 75 gm phytase in 100 kg of feed (with 13% wheat) can be safely used in the feed of broiler.
EFFECT OF TWO STAGE DRYING EMPLOYING FLUIDIZED BED DRYING, TEMPERING FOLLOWED BY FIXED BED DRYING ON HEAD RICE YIELD OF BRRI DHAN28 RICE VARIETY IN BANGLADESH
Authors: Wazed Md. Abdul , Mozumder N. H. M. Rubel , Sarker Md. Sazzat Hossain
Published: November 2021

Drying of high moisture paddy to achieve quality milled rice is an important issue in a paddy producing country like Bangladesh. This study has been conducted to investigate the impact of two stage drying technique namely, fluidized bed drying, tempering and followed by fixed bed drying method on quality of BRRI Dhan28 rice variety in terms of head rice yield (HRY). Moist paddy was dried in fluidized bed dryer (FBD) as first stage drying to reduce moisture from 25-27% to 18-19% using three drying temperatures of 120, 130, and 150°C at three bed thicknesses of 8, 10, and 12 cm. The first stage dried samples were immediately tempered for 30 minutes and dried in second stage drying by fixed bed dryer using 40±10C temperature maintaining bed thickness as 30 cm for the further reduction of moisture content to 13-14% (wb). Sun drying method was followed as complete drying of control sample. Control sample was used to compare the milling quality of rice dried in two stage drying technique. In addition, head rice yield was also compared to existing industrial paddy drying complexes. The results revealed that HRY of rice samples obtained from different drying methods was comparable. All the sets of drying parameters in two stage drying yielded better quality HRY than the control and even existing industrial drying method. The highest HRY (53.43%) of milled rice was obtained in the two-stage drying. On the other hand, the samples dried in the sun drying and industrial drying using Louisiana State University (LSU) dryer yielded 49.77% and 48.25% HRY, respectively. Therefore, the two-stage drying technique can be used for drying of high moisture paddy to obtain quality dried rice.