bluuebunny/crossref_metadata_2025 huggingface dataset:
Identifying SOX17 as a sensitive and specific marker for ovarian and endometrial tumors
Authors: Shaker Nada , Chen Wei , Sinclair William , Parwani Anil , Li Zaibo
Published: July 2022

Like PAX8, SOX17 was recently identified as a master transcription factor of ovarian cancer based on RNA sequencing data. We explored SOX17’s utility in diagnosing ovarian tumors and other gynecologic tumors. We systematically evaluated SOX17 expression on tissue microarrays from 398 ovarian tumors of various types, 93 endometrial carcinomas, 80 cervical carcinomas, and 1,055 non-gynecologic carcinomas from kidney, thyroid, breast, colon, bladder, liver and bile duct. In addition, SOX17 expression was evaluated on whole tissue sections from 60 gynecologic carcinomas and 10 angiosarcomas. The results demonstrated that SOX17 was highly expressed in most ovarian and endometrial tumors with strong intensity, but unlike PAX8, it was predominately negative in other tested tumor types including kidney and thyroid tumors. Specifically, SOX17 was highly expressed in the following types of ovarian tumors: serous carcinoma, clear cell carcinoma, endometrioid carcinoma, and germ cell tumors. SOX17 was mostly negative in mucinous carcinoma and sex cord stromal tumors. In addition, SOX17 was expressed in vascular endothelial cells and positive in all tested angiosarcomas. In summary, our results demonstrate that SOX17 is a sensitive and specific marker for ovarian non-mucinous carcinomas and endometrial carcinomas with a comparable sensitivity, but better specificity than PAX8. Furthermore, SOX17’s positivity in endothelial cells serves as an internal positive control, making it an excellent marker.
Observer-based Controller Design for Semi-Markov Jump Systems With Multiple Disturbances and Input Saturation
Authors: Ren Shuaishuai , Wei Yunliang , Zhang Qincheng
Published: July 2022

This paper discusses the observer-based H ∞ control problem for semi-Markov jump systems (S-MJSs) with generally uncertain transition rates (TRs) and input saturation, where the S-MJSs also consider H 2 -norm bounded disturbances and exosystem generated disturbances. First, the sufficient conditions for the local stochastic stability of the closed-loop system are given. Then, a full-order observer is designed to observe both the system state and external disturbance. Based on its estimated values, the composite controller is constructed to guarantee the system performance, and solvability conditions are proposed to ensure the closed-loop system to be the local stochastic stability with H ∞ performance level. Further, the maximum estimation of the attraction domain is given by an optimization problem. Finally, the effectiveness of the proposed method is verified by numerical example.
Host-delivered RNAi mediated silencing of HaAce1, encoding the major isoform of acetylcholinesterase, imparts resistance against the polyphagous insect-pest, Helicoverpa armigera
Authors: Jaiswal Sandeep , K Venkat Raman , Saini Ravi Prakash , Tilgam Jyotsana , Gurusamy Dhandapani , Sreevat Rohini , Pattanayak Debasis
Published: July 2022

The polyphagous insect pest, Helicoverpa armigera, is a detriment to crop productivity. Host-delivered RNAi has emerged as a potential tool to complement Bt technology for controlling insect pest menace. In this study transgenic tobacco ( Nicotiana tabacum L.; cv. Petit Havana) plants expressing dsRNA targeting the H. armigera gene, HaAce1 , encoding the major isoform of acetylcholinesterase, were developed. A 643 nucleotide RT-PCR amplified HaAce1 cDNA fragment was ligated in sense and antisense orientation intervened by GBSS intron to develop an inverted repeat (IR) gene construct. The HaAce1 IR gene construct (IR- Ace1 ) under the transcriptional control of CaMV 35S promoter and NOS terminator was used for Agrobacterium -mediated transformation of tobacco leaf disc explants. Fourteen HaAce1- hpRNA tobacco transgenic lines were obtained after screening of 31 putative transformants by PCR and RT-PCR. Five HaAce1- hpRNA tobacco transgenic lines demonstrated high level of resistance against H. armigera larvae based on detached leaf insect bioassay. These selected five tobacco transgenic lines carried two to four copies of the transgene . Generation of HaAce1 -specific siRNA was detected in these tobacco transgenic lines. Semi-quantitative PCR revealed many-fold reductions in the steady-state level of HaAce1 mRNA in larvae fed on leaves of the selected transgenic tobacco lines compared to that in control tobacco leaf-fed larvae. Our findings demonstrate that the host delivered dsRNA targeting Ace1 gene could be a promising strategy for controlling insect pest menace in crops.
Olmesartan alleviates symptoms of chronic fatigue syndrome in mice
Authors: Saqulain Sadique , Sharma Rahul Kumar , Kushwah Ajay Singh , Kumar Manish
Published: July 2022

Chronic fatigue syndrome (CFS) or myalgic encephalomyelitis (ME) is a lifestyle-related ailment that affects physical and mental abilities. The etiology is largelyunidentified but there are certain multifactorial mechanisms responsible such as mitochondrial aerobic pathways aberrations, hypothalamic-pituitary-adrenal (HPA) axis deregulation, immune hyperactivation, free radicals, pathogen infections, and central neurohumoral alterations. Olmesartan is an antihypertensive drugthat acts on the angiotensin 1 (AT1) receptor. The present research evaluatedthe efficiency of OlmesartanagainstCFS. CFSwas induced by lipopolysaccharide (LPS, 1mg/kg,i.p.) once on day 1 trailed by a forced swim (10minutes)continued for 21 consecutive times once each day. Olmesartan (1and 3mg/kg,p.o.) and dexamethasone (standard drug, 0.5mg/kg, i.p.) were given from the 1st to 21stday. Immobility time was noted in the forced swim test (FST). Elevated plus maze, raised zero maze, and open field tests were employed to assess animal behavior.Plasma glucose and cortisol, lipid peroxidation, and GSH levels were determined in the whole brain. LPS and repeated forced swim sessions instigated symptoms of CFS such as memory deficit and depression and anxiety-like symptoms. Findings suggested that Olmesartan shortened the immobility period of mice against CFS in FST. Olmesartan reduced memory deficits, increased ambulation, and exerted an anxiolytic effect. Olmesartan treatment reduced blood cortisol levels, brain TBARS, and enhanced brain GSHin the CFS mouse model. Hence, Olmesartan may prove to be an effective treatment for CFS and related behavioral discrepancies.
Perceived home and host country institutional environment pressures by bilateral development cooperation agency's constituents
Authors: Fushimi Katsutoshi
Published: July 2022

Public organisations have been rarely the subjects of neo-institutional research. Intra-organisational behaviour has been under-researched, too. This study examined how four distinct groups of bilateral development cooperation agency (BDCA) staff perceive institutional environment pressures from home and host countries. 131 valid responses obtained through an online survey were analysed. Both the HQ and the OOs staff identically felt a powerful home country accountability pressure. This tendency is prominent for management staff. The test results, as seen through the lens of a neo-institutional perspective, suggest that OOs staff prioritise answerability to home country stakeholders over that to host country stakeholders.
Is there a correlation between positive antiphospholipid antibodies and renal involvement in IgA vasculitis?
Authors: Yeganeh Mehrnoush Hassas , Sinaei Reza , Yaraghi Aye , Rahmani Khosro , Parvaneh Vadood Javadi , Shiari Reza , Hosseinzadeh Hamid
Published: July 2022

The authors have requested that this preprint be removed from Research Square.
Hybrid chitosan/CaO-based nanocomposites doped with plant extracts from Azadirachta indica and Melia azedarach: evaluation of antibacterial and antibiofilm activities
Authors: Paunova-Krasteva Tsvetelina , Hemdan Bahaa A. , Dimitrova Petya D. , Damyanova Tsvetozara , El-Feky Amal M. , Elbatanony Marwa M. , Stoitsova Stoyanka , El-Liethy Mohamed Azab , El-Taweel Gamila E. , Nahrawy Amany M. El
Published: July 2022

This study examines substances from plant leaves of Azadirachta indica and Melia azedarach extracted with methanol (80%) and then successively fractionated with increasing gradient polarity solvents. The methanol extract from the two plant leaves was selected to be incorporated with nanocomposites because of their high antimicrobial activities. HPLC analysis was performed for the determination of total phenolics and flavonoids. LC-ESI-MS positive ion acquisition mode revealed the presence of four main chemical classes; limonoids, triterpenes, fatty acids, and phenolics. Sol-gel processes were adapted to prepare CaO/chitosan composite loaded with the methanol extract of the two plant leaves, acting as innovative antibacterial agents. The fabricated nanocomposites were characterized by XRD, TEM, SEM, and FT-IR methods. Minimal bactericidal concentrations (MBC) were established by agar plating using bacteria treated with MIC and at least 2 concentrations double-higher than the MIC. Biofilm was cultivated in the presence of sub-MICs of the extracts and the nanocomposites, followed by quantification with the crystal violet assay. The examined chitosan-CaO-based hybrid nanocomposites loaded with the methanol fractions from the leaves of A. indica and M. azedarach had an excellent performance as biofilm inhibitors. This indicates their good potential for biomedical applications.
Acceptability and expected changes in parental practices after an online behavioural parent program for ADHD during the Covid-19 pandemic
Authors: Rahaly Myriam , Fongaro Erica , Franc Nathalie , Nesensohn Jessica , Purper-Ouakil Diane , Kerbage Hala
Published: July 2022

Background: Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder in children and adolescents, characterized by attention deficit, hyperactivity, and impulsivity. Treatments for this population should be multidisciplinary and must be initiated as soon as possible. Non-pharmacological interventions for ADHD include psychoeducation, parent behavioural training programs and school interventions and accommodations. In response to the COVID-19 pandemic, we developed an online version of a combined psychoeducation and behavioural training program to facilitate access to mental health treatment and ensure continuity of care. The study assessed the acceptability of this online parent training program, among parents and/or caretakers of children and adolescents with ADHD. Methods: The program consisted of 10 online sessions over the course of 2 consecutive days (5 sessions a day). Satisfaction, usefulness and general comments about the program were assessed with open-ended questions and visual-analogous scales. Parents/caretakers’ use of strategies to manage behavioural problems was assessed using the Parenting and Family Adjustment Scales. Results: A total of 206 parents participated in the online program and 175 of them completed the evaluation. Overall, participants were satisfied with the content of the program and found it beneficial for their child. The engagement was high and no major obstacles were identified to participation, except some internet connection issues. More than half of participants had already used some of the strategies included in the program. Despite this, some difficulties in implementing new strategies were observed. Conclusions: Our study contributes to the growing body of papers evaluating online behavioral training program to improve their efficacy and content. With these measures, we hope to improve engagement in online psychoeducation and behavioural therapy programs. Future research evaluating online behavioural training programs should focus on ways to make them more accessible and adaptable to families’ obstacles.
Risk assessment and pre-alarm on invasive peculiarities of ornamental grasses to the urban greening routine
Authors: Chao Chen , Wen-Jun Teng , Hui Zhang , Ju-Ying Wu , Scullion John , Bye Ruby
Published: July 2022

Two risk assessment protocols, the Weed Risk Assessment for Central Europe (WG-WRA) and the Australian Weed Risk Assessment (WRA), were adapted to evaluate the invasion risk of eighty-two ornamental grasses. Meanwhile, some particular characteristics of these ornamental grasses, like ornamental value, biological and ecological characteristics were highlighted and assessed for their potential risk by field observations and method of expert ranking. There was a positive correlation between scores derived from the two risk protocols, though WRA was considered to be more acceptable than WG-WRA according to the analysis of ornamental grasses. Anyhow, well-cultivated cultivars were less-efficiently predicted by the two risk protocols compared with the protospecies in the study, as well as some outliers with higher fecundity. In details, the risk classification differed: risk categorization using the WG-WRA protocol allocated high and moderate risk to 81.1% of 45 native grasses, yet only 22.2% of 37 alien species. Assessment using the WRA protocol scored 91.5% of the studied grasses to pose invasion risk following a diverse criterion, of which 97.3% were for native species and 86.7% for alien species. On details, ranked scores of biological and ecological characteristics of ornamental grasses highlighted herein were correlated with risk scores, although the significance of these relationships varied; while ornamental value had a weak relationship to the risk scores. In addition, some features peculiar to ornamental grasses relating to their invasive tendency are presented that most (72.0%) of the alien ornamental grasses exhibit perenniality, intentionally introduced from the Americas and Europe, and to a lesser extent from Asia, Africa, and Australia. In general, the ornamentals with high fecundity and adaptability presented a higher risk of invasion, while well-domesticated cultivars or hybrid species with high aesthetic scores yet relatively low levels of fecundity and adaptability, presenting a low invasion risk. Thus, special attention should be paid to the invasive characteristics of ornamental grasses to mitigate risks to agriculture and local ecosystems and also some amendments are needed to improve the risk assessment protocols at some certain case or even a larger scale during application in projects of urban greening and environmental restoration.
Estimation and feasibility of correction modelling for mother-reported child height and weight at 2 years using data from the Australian CHAT trial
Authors: Cheng Yan , Xu Huilan , Rissel Chris , Phongsavan Philayrath , Buchanan Limin , Taki Sarah , Hayes Alison , Baur Louise A , Wen Li Ming
Published: July 2022

Background
Correction modelling using reported BMI values has been employed in adolescent and adult populations to improve the accuracy of self-reporting.
Objective
This study aimed to evaluate the feasibility of establishing correction modelling for mother-reported child height and weight at 2 years using data from an Australian trial in 2019.
Methods
Correction modelling for BMI was conducted using mother-reported and objectively measured height and weight of 2-year-olds. Mother-reported height, weight and BMI values of 2-year-old children were adjusted based on objectively measured anthropometric data using linear regression models. ‘Direct’ and ‘indirect’ corrections were applied to the correction of BMI values. We defined the direct collection as using corrected BMI values that were predicted directly by the model and indirect correction as using corrected weight and height values to calculate corrected BMI values.
Results
Corrected BMI values via the indirect correction showed higher sensitivity or similar specificity in predicting overweight status, compared to the direct correction, and also showed higher agreement with measured values compared to the mother-reported measures.
Conclusions
Corrected self-reported measures via an indirect correction had a better accuracy and agreement with the objectively measured data in the BMI values and classification of overweight, compared to the mother-reported values.
Functional constipation is associated with a decline in word recognition 2 years later in community-dwelling older adults: The Korean Frailty and Aging Cohort Study
Authors: Jang Hoseok , Kim Sunyoung , Kim Byungsung , Kim Miji , Jung Jaehoon , Won Chang Won
Published: July 2022

Background: Constipation is one of the most common health problems among the elderly, and cognitive impairment is also a major health problem among the elderly. Identifying risk factors for cognitive impairment is important to prevent many cognitive disorders. Though studies on cognitive decline in patients with Parkinson’s disease are available, no study has explored the predictive effect of functional constipation on cognitive decline in non-Parkinson’s elderly individuals. This study aimed to determine the association between constipation and cognitive decline in community-dwelling older adults. Methods: This is a 2-year longitudinal analysis of cohort study data, including 851 community-dwellers as participants at the baseline survey who took part in the Korean Frailty and Aging Cohort Study and completed a follow-up survey. A neuropsychological test (CERAD-K, the Consortium to Establish a Registry for Alzheimer's Disease Assessment Battery) and the Korean version of the Frontal Assessment Battery were used to evaluate comprehensive cognitive function. Functional constipation was defined according to the ROME IV criteria. Analysis of covariance was used to identify the association between functional constipation and cognitive decline statistically.Results: Among the 851 participants, 8.9% had functional constipation. The mean age of the functional constipation group (78.6 ± 3.9) was higher than that of the non-constipation group (77.5 ± 3.8). Patients in the functional constipation group were more likely to have low physical activity (15.8% vs. 8.8%), polypharmacy (61.8% vs. 45.5%), and depression (30.3% vs. 17.4%). After adjusting for potential confounding factors, including age, low physical activity, polypharmacy, type 2 diabetes mellitus, depressive disorder, and baseline cognitive function test score, the mean changes in word recognition test scores from 2018 to 2020 were -0.071 and -0.524 in the no-constipation and constipation groups, respectively (P=0.009). Changes in other cognitive function tests showed a tendency to be lower in the constipation group (memory -0.138 vs. -0.489, recall -0.296 vs. -0.407, digit span -0.248 vs. -0.379, frontal assessment battery 0.281 vs. 0.12, trail making test 0.143 vs. 5.38), but were not significantly different.Conclusions: Functional constipation at baseline was associated with a decline in word recognition after two years.
Data Analysis and Graphical observations of real-time RT-PCR of Hepatitis C Virus to determine the range of qualitative assays and to differentiate it from quantitative assays
Authors: Joseph Ann M. , Yathi Krishna K. , Jacob Jose
Published: July 2022

Hepatitis C Virus (HCV) load in plasma were often below the validated quantitative RT-PCR (RT-qPCR) calibration plot concentrations. In this report, data analysis of RT-PCR amplification plots and calibration plots were done to define the performance characteristics of the higher Cq range of qualitative RT-PCR and to differentiate it from RT-qPCR. This is the first report to establish the decision criteria for validation of qualitative real-time HCV RT-PCR assays. Patients reactive for anti-HCV antibody screening assays or exposed to HCV infection were selected for RT-PCR assay done with RNA isolated from plasma. Normalised fluorescence intensity (100%) and slope (1.65–1.50) of the sigmoid fluorescence amplification plots were of acceptable performance for validated quantitative calibrators (10,000–10 IU/µl), but were decreased for diluted calibrators and for patients’ sample with Cq greater than that of the 10 IU/µl validated calibrator (Cq > 33.2). Calibration plot of validated calibrators had slope, efficiency and sensitivity of -3.471, 94% and 36.404, respectively, but the diluted calibrators showed decreased performance of -2.305, 171% and 35.52, respectively. Log-transformed exponential amplification plots analysed by LinRegPCR software, showed acceptable performance at the validated calibrator concentrations and decreased performance with diluted calibrators and patients’ sample with Cq > 33.2. The four-parameter validated sigmoid fluorescence amplification plot of qualitative RT-PCR Cq range was from 33.2 to 39.9. The 10 IU/µl calibrator was the reference point to differentiate between qualitative and quantitative RT-PCR. A systematic decision-criteria had been developed for this purpose from the data analysis of graphical observations, four-parameter sigmoid curve fitting model, exponential amplifications of individual RT-PCR plots and calibration plots.
Effectiveness of grey and green engineered solutions for protecting the low-lying muddy coast of the Chao Phraya Delta, Thailand
Authors: Charoenlerkthawin Warit , Bidorn Komkrit , Burnett William C. , Sasaki Jun , Panneerselvam Balamurugan , Bidorn Butsawan
Published: July 2022

Coastal protection measures can be categorized into grey and green solutions in terms of their ecosystem impacts. As the use of grey solutions has become a serious issue due to environmental consequences during the last few decades, green/nature-based solutions have become prioritized. This study evaluates the effectiveness of grey and green solutions applied along the eastern Chao Phraya Delta (ECPD) based on historical shoreline change analysis and coastal observations using Light Detection and Ranging (LiDAR) technology. The results from shoreline analysis indicate that nearshore breakwaters installed 100–250 m from the shoreline have successfully reclaimed the coastline with a sedimentation rate of 17–23 cm/y. Meanwhile, sand-sausage-submerged breakwaters were ineffective at stabilizing the coastline during 2002–2010 due to land subsidence. With a low subsidence rate, the rubble-mound-submerged breakwaters can reduce the shoreline retreat rate with a vertical deposition rate of about 5 cm/y. In contrast, use of a bamboo fence, a green solution widely used along muddy coasts, traps sediment at a rate of less than 1.3 cm/y and typically lasts only for 2–3 years after installation. Decomposed bamboo causes environmental degradation so local communities disapprove of the approach. Results reveal that grey solutions are more effective for stabilizing the ECPD coastline and result in less coastal environmental impact than the nature-based solution using a bamboo fence.
Gene Expression Profiling of Fibroepithelial Lesions of the Breast
Authors: Li Xiaomo , Vail Eric , Maluf Horacio , Chaum Manita , Lownik Joseph , Che Mingtian , Giuliano Armando , Dadmanesh Farnaz
Published: July 2022

Fibroepithelial lesions of the breast (FELs) are a heterogeneous group of neoplasms exhibiting a histologic spectrum ranging from fibroadenomas (FAs) to malignant phyllodes tumors (PTs). Despite published histologic criteria for their classification, it is common for such lesions to exhibit overlapping features, leading to subjective interpretation and inter-observer disagreements in histologic diagnosis. Therefore, there is a need for a more objective diagnostic modality to aid in the accurate classification of these lesions and to guide appropriate clinical management. In this study, the expression of 750 tumor-related genes was measured in a cohort of 34 FELs (5 FAs, 9 cellular FAs, 9 benign PTs, 7 borderline PTs, and 4 malignant PTs). Differentially expressed gene analysis, gene set analysis, pathway analysis, and cell type analysis were performed. Genes involved in matrix remodeling and metastasis (e.g., MMP9, SPP1, COL11A1), angiogenesis (VEGFA, ITGAV, NFIL3, FDFR1, CCND2), hypoxia (ENO1, HK1, CYBB, HK2), metabolic stress (e.g., UBE2C, CDKN2A, FBP1), cell proliferation (e.g., CENPF, CCNB1), PI3K-Akt pathway (e.g., ITGB3, NRAS) were highly expressed in malignant PTs and less expressed in borderline PTs, benign PTs, cellular FAs, and FAs. The overall gene expression profiles of benign PTs, cellular FAs, and FAs were very similar. Although a slight difference was observed between borderline and benign PTs, a higher degree of difference was observed between borderline and malignant PTs. Additionally, the macrophage cell abundance scores and CCL5 were significantly higher in malignant PTs compared with all other groups. Our results suggest that the gene expression profiling-based approach could lead to further stratification of FELs and may provide clinically useful biological and pathophysiological information to improve the existing histologic diagnostic algorithm.
Screening of potential hub genes and key pathways associated with breast cancer by bioinformatics tools.
Authors: Oumeddour Abdelkader
Published: July 2022

Purpose Breast cancer (BC) remains the main leading cause of cancer death in women worldwide. Developing new-targeted therapies remains an area of growing interest that may improve patient survival. Therefore, the aim of this study was to analyze the differentially expressed genes (DEGs) involved in BC development and progression to better predict biomarkers, which may be used as targeted therapies.Methods DEGs were picked out from three gene expression profiles GSE55715, GSE124646 and GSE87049 using GEO2R tool and Venn diagram software. Then, these DEGs were analyzed by different bioinformatics tools, including gene ontology (GO) and pathway enrichment analysis, protein-protein interaction (PPI), survival analysis, expression validation in BC tissues, transcription factor identification and immune cell infiltration, to explore key genes involved in BC progression.Results A total of 146 DEGs were identified in the three datasets, including 60 up-regulated genes were enriched in cell cycle, oocyte meiosis, progesterone-mediated oocyte maturation, p53 signaling pathway, HTLV-I infection and Hepatitis B, while 86 down-regulated genes were enriched mainly in phenylalanine metabolism, tyrosine metabolism, melanogenesis, mineral absorption, TNF signaling pathway and pathways in cancer. Furthermore, ten hub genes were obtained: BUB1, CDK1, HMMR, MAD2L1, CEP55, AURKA, CCNB2, TPX2, MELK and KIF20A. The overexpression levels of hub genes, except CDK1, were associated with the poor survival in BC, and regulated by several transcription factors (TFs) involved in DNA binding activity and transcription regulation. The infiltration levels of immune cells were positively correlated with these hub genes, especially macrophages and CD4+ T cells.Conclusion In conclusion, this study provides reliable molecular biomarkers that can become potential therapeutic targets in BC treatment.
Pricing Design for a Low Carbon Economy
Authors: L Alberto Lamadrid , Shi Xin , Zuluaga Luis
Published: July 2022

We study the problem of deriving financially adequate prices for trading a perishable commodity under a centralized auction with environmental considerations. Our model is inspired by electricity markets, with conventional producers having byproduct emissions; and environmentally clean producers without emissions but subject to weather uncertainty. We derive a new market clearing pricing scheme that takes into account the marginal costs associated with operations at maximum capabilities. Our pricing scheme guarantees revenue adequacy for the market administrator, cost recovery for all producers, and allows to analyze the effects of environmental limitations. We illustrate our model calibrating to data from U.S. markets.
We show how our design alters the participation of conventional and clean producers, and provides revenues to compensate the capital costs required to decarbonize production portfolios, and decrease the emissions produced by the market (system) being considered.
On n-quasi-(m,q)-isometric operators on a Banach space
Authors: Gherairi Khadija
Published: July 2022

In this paper, we introduce the class of n-quasi-m-isometric op-erators on a Banach space. Such a class seems to be a natural generalizationof m-isometric operators on Banach spaces and of n-quasi-m-isometric oper-ators on Hilbert spaces. We start by giving some of their elementary prop-erties, studying the products and the power of such operators. Next, we willexplain the relation between C 0 -semigroups, n-quasi-(m, q)-isometric operatorsand (m, q)-isometric operators. Finally, we focus on the dynamic of an n-quasi-m-isometry. More precisely, we prove a result characterizing the supercyclicityof such a class.
SIMD vectorization for simultaneous solution of locally varying linear systems with multiple right hand sides
Authors: Kühn Martin J. , Holke Johannes , Lutz Annette , Thies Jonas , Röhrig-Zöllner Melven , Bleh Alexander , Backhaus Jan , Basermann Achim
Published: July 2022

Developments in numerical simulation of flows and high performance computing influence one another. More detailed simulation methods create a permanent need for more computational power, while new hardware developments often require changes to the software to exploit new hardware features.This dependency is very pronounced in the case of vector-units which are featured by all modern processors to increase their numerical throughput but require vectorization of the software to be used efficiently. We study the vectorization of a simulation method that exhibits an inherent level of vector-parallelism. This is of particular interest as SIMD operations will hopefully be available with std::simd in a future C++ standard.The simulation method considered here results in the simultaneous solution of multiple sparse linear systems of equations which only differ by their main diagonal and right hand sides. Such structure arises in the simulation of unsteady flow in turbomachinery by means of a frequency domain approach called harmonic balance.
High expression of MAGOH is closely associated with poor prognosis of gliomas
Authors: Wu Birui , Zhang Juntao , Tan Dianhui
Published: July 2022

Background: MAGOH (Mago homolog, exon junction complex subunit) is a protein-coding gene，which mediates mRNA processing. Studies have shown that MAGOH promotes gastric cancer by activating the B-Raf/MEK/ERK signaling pathway. Furthermore, this gene is involved in the development of breast cancer and prostate cancer. Therefore, we hypothesized that MAGOH also affects the formation and development of gliomas. Methods: Sequential data filtering (survival analysis, independent prognostic analysis, ROC curve analysis, and clinical correlation analysis) was performed using information on gene expression and clinical data from the Chinese Glioma Genome Atlas (CGGA) microarray database. Then, bioinformatics analysis (Kaplan-Meier survival analysis, univariate Cox analysis, multivariate Cox analysis, and ROC curve analysis) using CGGA and The Cancer Genome Atlas (TCGA) microarray was used to analyze biological manifestation of MAGOH. Gene set enrichment analysis and immune infiltration analysis were performed for this gene. R language, Perl and GSEA software were used for statistical analysis and graphic processing. Results: Kaplan-Meier survival analysis, univariate Cox analysis, multivariate Cox analysis and ROC curve analysis showed that MAGOH was an independent prognostic indicator in glioma patients, and its up-regulation was closely associated with poor prognosis of glioma patients. In addition, enrichment analysis and immune infiltration analysis showed that the immune score and interstitial score were significantly related to the survival of glioma patients. Moreover, MAGOH was closely related to the immune infiltration and inflammatory response of glioma. Conclusion: MAGOH is an independent prognostic factor in glioma patients, especially in low-grade glioma patients. MAGOH may affect the survival of glioma patients by promoting the infiltration of B cells, but inhibiting infiltration of CD4+ T cells and CD8+ T cells and activating the cell metabolism of glioma. MAGOH may be an important biomarker for the treatment of glioma.
Reconfigurable Intelligent Surface-assisted Space-Time Shift Keying
Authors: Liu jiayu , Chen Dongxiao , Bian lina , Xu xiaoting , Zhou yueru , jing xiaoping
Published: July 2022

Reconfigurable Intelligent Surface (RIS), which improves the performance of wireless communication systems by controlling the reflection/scattering characteristics of incident waves without increasing energy consumption, appears as a promising candidate for future wireless communication systems. In this paper, a RIS-based space-time shift keying (STSK) scheme is proposed. On the one hand, the reflection phase shifts at RIS are optimized by the channel gain maximization criterion to obtain better RIS-STSK performance; on the other hand, the theoretical average bit error probability (ABEP) of the RIS-STSK scheme is derived using a semi-analytical probabilistic approach. In addition, for improving the performance gain of the RIS-STSK scheme, an improved genetic algorithm is designed to assist the optimization of the reflection phase shifts at RIS. Simulation results show that the proposed RIS-STSK scheme performs better than the STSK scheme, and the proposed improved genetic algorithm can significantly enhance the performance gain of RIS-STSK.
The Control Strategy of Mixed Platoon Based on Vehicle Grouping with Abnormal Communication in Two-Lane Highway
Authors: Jin Shuang , Jiang Shixin , Yang Xiangli
Published: July 2022

The mixed platoon including human driving vehicles (HVs) and connected automated vehicles (CAVs) are becoming more common. In order to alleviate the traffic congestion of highway, we present a control strategy of mixed platoon based on vehicle grouping with abnormal communication for two-lane. First, we grouped the vehicles on the road into many small platoons according to the spatial location of the CAVs, and then proposed the CAVs control algorithm under the mixed platoon. Based on this, combined with the vehicle dynamics characteristics, we analyzed the string stability of the mixed platoon. In addition, by considering the abnormal communication of CAVs during driving, we propose a control strategy for vehicle split and vehicle formation in the two-lane situation. Through VISSIM verification, it can be seen that the method proposed in this paper has a significant effect on the improvement of mixed traffic efficiency.
Nuclear matter effects on jet production at electron-ion colliders
Authors: Li Hai Tao , Liu Ze Long , Vitev Ivan
Published: July 2022

In these proceedings we report recent progress on understanding hadron and jet production in electron-nucleus collisions at the future Electron-Ion Collider [1,2].
These processes will play an essential role in the exploration of the partonic structure of nuclei and the study of parton shower evolution in strongly-interacting matter. We employ the framework of soft-collinear effective theory, generalized to include in-medium interactions, to present the first theoretical results for inclusive hadron and jet cross sections, as well as the jet charge modification in deep inelastic scattering on nuclei. We further demonstrate how to separate initial-state and final-state effects.
Impact of LHC dijet production in pp and pPb collisions on the nNNPDF2.0 nuclear PDFs
Authors: Abdul Khalek Rabah
Published: July 2022

We quantify the impact of LHC dijet production measurements on the nNNPDF2.0 nuclear PDFs in twofold. First, from a proton baseline based on NNPDF3.1 and augmented by pp dijet production measurements from ATLAS and CMS at 7 and 8 TeV. Second, from a new nNNPDF2.0 global analysis including the ratio of pPb to pp dijet spectra from CMS at 5 TeV. We show that as opposed to the CMS at 5 TeV absolute pp and pPb dijet spectra, the pPb/pp ratio is well described in a nPDFs fit and provides strong constraints on the gluon of lead.
New 2- and 3-loop heavy flavor corrections to unpolarized and polarized deep-inelastic scattering
Authors: Ablinger Jakob , Blümlein Johannes , De Freitas Abilio , Saragnese Marco , Schneider Carsten , Schoenwald Kay
Published: July 2022

A survey is given on the new 2-- and 3--loop results for the heavy flavor contributions to deep--inelastic
scattering in the unpolarized and the polarized case. We also discuss related new mathematical aspects
applied in these calculations.
Development of the ATLAS Liquid Argon Calorimeter Readout Electronics for the HL-LHC
Authors: Kolb Mathis
Published: July 2022

The full ATLAS Liquid Argon Calorimeter electronic readout chain will be upgraded for the high-luminosity LHC.
The upgrade is designed to withstand the expected radiation level and to be compatible with the Phase-I Digital Trigger System which is being installed right now.
Analogue electronics shape and amplify the calorimeter signals before they are digitized with 16 bit dynamic range on two gain scales.
The on-detector system samples the calorimeter cell signals at 40 MHz and sends them to the off-detector electronics which apply digital processing based on FPGAs.
Design studies and tests of prototypes of the upgraded components are presented.
Entanglement, partial set of measurements, and diagonality of the density matrix in the parton model
Authors: Duan Haowu
Published: July 2022

To study quantum properties of the hadron wavefunction at small x, we derived the reduced density matrix for soft gluons in the CGC framework. We explicitly showed that the reduced density matrix is not diagonal in the particle number basis. The off-diagonal components are usually ignored in the conventional parton model. We thus defined the density matrix of ignorance
by keeping only the part of the reduced density matrix which can be probed in a limited set of experimental measurements. We calculated Von Neumann entropy for both the reduced and ignorance density matrices. The entropy of ignorance is always greater than the entanglement entropy (computed drom the reduced density matrix) of gluons. Finally, we showed that the CGC reduced density matrix for soft gluons can be diagonalized in a thermal basis with Boltzmann weights suggesting thermalization of new quasi-particle states which we dubbed entangolons.
OVERVIEWS ON RECYCLING OF POST-CONSUMER PET BOTTLES AND APPLICATIONS OF RPET
Authors:   Associate Professor, Department of Chemistry, J. V. Jain College, Saharanpur-247001., Kumar Lokesh
Published: July 2022

In this review the various aspects related to the recycling of Waste PET bottles, their adequate methods of disposal and management are focused. PET is not as harmful as other polymeric waste but its huge volumes is a big threatening to environment, due non-biodegradability of it, contaminates soil, water and also becomes habitat of rodents/insects. These problems make necessity to recycled PET. Advanced technologies and methods of recycling of Post-consumer PET bottles, and their utilization after recycling, are discussed. This review summarizes the efforts of researchers on the proper utilization of rPET in road pavement, textile, concrete and feedstocks of many valuable chemicals, which has significant effect on environment pollution. The industrial utilization of rPET is cost effective, it is cheap as compared to virgin PET.
CLINICAL CHARACTERISTICS, MANAGEMENT PRACTICES AND IN-HOSPITAL OUTCOMES OF SCRUB TYPHUS PATIENTS IN A TERTIARY CARE CENTER IN THE NORTH EASTERN STATE, TRIPURA
Authors:   Post Graduate Trainee, Department of Medicine, Agartala Government Medical College., Shil Bibhas , Rani Ghosh Susmita ,   Post Graduate Trainee, Department of Radiology, Agartala Government Medical College., Pandharipande Atharva ,   Post Graduate Trainee, Department of Medicine, Agartala Government Medical College., Ranjan Das Bibhu ,   Post Graduate Trainee, Department of Medicine, Agartala Government Medical College., Ghosh Atanu ,   Associate Professor, Department of Medicine, Agartala Government Medical College., Dasgupta Arunabha ,   Professor and Head of the Department of Medicine, Agartala Government Medical College.
Published: July 2022

Background- With the changing epidemiology, scrub typhus is now among the commonest causes of AFI in India and a high suspicion should be maintained, and an early diagnosis and promt management is warranted to prevent complications. Objective - Clinical characteristics, management practices and in-hospital outcomes of scrub typhus patients. Methods- a Cross-sectional retrospective study was conducted among 110 scrub typhus patients attending Agartala Government Medical College and GB Pant Hospital, a tertiary care centre of Tripura in last one year period. Their clinical profile, laboratory studies and management has been recorded and data has been evaluated with SPSS 21.0 for windows with p- value <0.05. Results- the commonest presenting symptoms of scrub typhus are high-grade fever with chills , headache and it most commonly effects farmers. Most commonly effected age group was 40-50 years of age. Most of the patients were from West Tripura followed by Khowai Tripura and least patients were from North Tripura. Predominately it occured in September, October and November i.e. in post monsoon period. The pathognomonic eschar was present in 43% patients and rarest presentation was paraparesis (0.9%). Lymphadenopathy (9%), neck rigidity (6%), hepatomegaly (10%), splenomegaly (4%), acute respiratory distress syndrome was seen in 14% patients. Hepatic involvement was the most common complication seen in our study (42%). Anemia was present in 25% and thrombocytopenia was present in 22% patients. Subside of fever to doxycycline injection seen in 73% on day1 and 84% on day2. 19% Patient required icu admission. 9% developed ARDS and 6% required ET tube intubation and mechanical ventilation. 6% developed hypotension requiring inotropic support. 4% developed severe thrombocytopenia(<10,000) required platelet transfusion. 11% developed acute kidney injury requiring haemodialysis. Survival rate were 93% and mortality 7%. In conclusion, scrub typhus became the leading infectious cause of acute febrile illness in North eastern state, Tripura. A high suspicion should be maintained, and an early diagnosis and promt management is warranted to prevent mortality and morbidity of patients.
DESIGN AND VALIDATION OF EDUCATIONAL THEORIES-BASED FRAMEWORK FOR E-LEARNING SYSTEMS
Authors:   Bahria University Islamabad, Software Engineering Department, Islamabad, Federal Capital, Pakistan., Ashraf Sadia
Published: July 2022

Educational theories play a key role in attaining e-learning success. This contribution of theories is even more important for primary education which requires special attention since children possess childish behaviors.However, research shows that most e-learning systems lack theoretical foundations. We argue that these systems can be more effectively utilized by integrating educational theories. Therefore, we offer an e-learning system design framework based on learning and e-learning theories for primary education. The paper first discusses educational theories from different domains. Next, we provide an overview of how each theory can contribute toa successful e-learning system. Ethnographic Content Analysis (ECA) was conductedof the most renowned theories to construct this framework. Shortlisted theories belonged to domains of constructivism, early education, and e-learning. Design principles from each theory were extracted with the help of grounded theory methodology. These principles were mapped to e-learning system components including tasks, tools, and interfaces by performing thematic analysis.A comprehensive framework based on theoretical design principles was constructed. Lastly, the framework was validated by developing an e-learning system based on design principles. We evaluated students academic performance after they used the developed system for three weeks. Findings revealed that an e-learning system has great potential in primary education and can assist practitioners in achieving desired learning outcomes by integrating educational theories. It was also found that the sequence in which learning activities are performed can overshadow a systems performance and hence needs to be addressed for e-learning success.
A DESCRIPTIVE STUDY TO ASSESS THE KNOWLEDGE REGARDING DE-ADDICTION TREATMENT IN CLIENTS WITH ALCOHOL ADDICTION IN SELECTED COMMUNITIES OF GURUGRAM
Authors:   Assistant Professor, Department of Obstetrics and Gynaecological Nursing, Amity College of Nursing, Amity University, Gurugram, Haryana, India., Dillu Rebecca , Kumar Kanika ,   Tutor, Department of Mental Health Nursing, Amity College of Nursing, Amity University, Gurugram, Haryana, India.
Published: July 2022

Aim: A descriptive study to assess the knowledge regarding de-addiction treatment in clients with alcohol addiction in selected communities of Gurugram. Methodology: Non-Experimental descriptive design was adopted in the present study. Purposive sampling technique was used to select the sample size of 100 alcohol addict residing the selected communities of Gurugram. The assessment of knowledge was carried out using a structured knowledge questionnaire regarding the de addiction treatment in clients with alcohol addiction. Result:The findings of the study showed that maximum (45%) clients had average knowledge regarding de addiction treatment and most (43%) of clients had poor knowledge and only very few (12%) of clients had good knowledge regarding de addiction treatment. The knowledge of the client with alcohol addiction was assessed in 5 domains i.e. concept, causes, signs symptoms, complication and management. The sample showed maximum knowledge in the area of Concept regarding deaddiction treatment while least knowledge score was shown in the domain of Causes of alcohol addiction. Conclusion:The present study shows that sample had very less knowledge and awareness regarding de-addiction treatment therefore the health care professionals have a great opportunity to make the people aware about alcohol addiction causes, preventive measures alcohol addiction and de addiction treatment.
CHANGES IN ANATOMY EDUCATION - AN OVERVIEW OF THE IMPACT OF SOCIAL MEDIA ON MODERN MEDICAL EDUCATION
Authors:   Junior Resident, Department of Anatomy, All India Institute of Medical Sciences Rishikesh, Uttarakhand, India., Joseph Mathew , Singh Brijendra ,   Professor and Head, Department of Anatomy, All India Institute of Medical Sciences Rishikesh, Uttarakhand, India., Bhadoria Pooja ,   Assistant Professor, Department of Anatomy, All India Institute of Medical Sciences Rishikesh, Uttarakhand, India., Malhotra Rashmi ,   Additional Professor, Department of Anatomy, All India Institute of Medical Sciences Rishikesh, Uttarakhand, India.
Published: July 2022

Background: In the modern society, it is hard to see youngsters without a smartphone or any other social media accessible gadgets like smartwatches, laptops, tablets etc. Our study aimed to observe medical the students who are active in social media platforms and how do these platforms influence in their learning. Methodology: In this, we made an online feedback study for MBBS students of AIIMS Rishikesh (2017,2018 & 2019 batches). Responses were collected from students who use social media daily for academic purposes as well as for entertainment and communication using Google forms. Responses were analysed and compared. Result: Students who were active in departmental social media groups were found to secure higher positions in monthly evaluations/assessments. Conclusion: Social media have become an integral part of the modern lifestyle. It has many roles in educating younger generations. Teaching and learning methods involving social media platforms are to be incorporated in modern education policies from very lower classes up to professional courses at government level itself and not at any isolated institutional or departmental level.