bluuebunny/crossref_metadata_2025 huggingface dataset:
Social Media Advertising for Achieving Long-term Marketing Objectives
Authors: Abashidze Irakli
Published: September 2022

Increasing competition on consumer markets forces businesses to elaborate marketing plans focused on long-term perspectives. This is important in today’s fluctuating and unpredictable business environments, where high level of competitiveness and positive reputation is a premise of survival for a business. Otherwise, it will be unable to retain its share on consumer markets and make plans focused on long-term periods. In this regard, social media advertising is one of the most powerful strategies to reach various marketing goals: brand awareness and high brand value, positive reputation and word of mouth, growing customer base, high ROAS (return on ad spend) in short-term and CLV (customer lifetime value) in the long run. Therefore, it is necessary to research social media advertising in terms of achieving long-term marketing goals. The paper deals with various issues, including advertising opportunities of social media, ways of attracting and retaining customers, raising brand awareness and elaborating strategies focused on long-term results. Discussion provided in the paper is a result of literature review and the author’s observations. Each part of the paper contains recommendatory remarks for achieving long-term marketing goals by using social media advertising strategies. The paper is summarized by a brief conclusion.
Effet de la Densité de Mise en Charge sur la Croissance de la Palourde Amiantis umbonella Élevée sur les Sites de Douda et Obock (Djibouti)
Authors: Akélé David Giraud , Edéya Pelebe Rodrigue Orobiyi , Fagbemi Mohammed , Mohamed Djama Abdoul-Kadir , Adédjobi Lalèyè Philippe
Published: September 2022

La palourde Amiantis umbonella présente dans les zones intertidales sablonneuses/vaseuses en Asie constitue une source de protéines bon marché de ces régions. Malgré ces potentialités économiques, elle demeure peu étudiée à Djibouti où elle est fait l’objet d’une production. Cette étude a pour but d’étudier l’effet de la densité d’élevage sur la croissance de la palourde Amiantis umbonella. Les expériences ont été conduites sur les sites de Douda avec des densités de 50 individu/m2 et de 100 individu/m2 et Obock avec 50 individu/m2. La taille et le poids des spécimens ont été mesurés toutes les deux semaines, pendant 6 mois de mars à aout 2018. La température moyenne était de 36°C. Les paramètres de croissance des palourdes ont été estimés avec l’équation de Von Bertalanffy. A la densité de 50 individus/m2, les constantes de croissance K étaient de 0,13 cm/mois et 0,15 cm/mois respectivement à Douda et Obock tandis qu’elle était de 0,11cm/mois pour une densité de 100 individus/m2à Douda. Ainsi, il ressort que la taille commerciale (40 mm) a été obtenue plutôt après 8 semaines à Douda à la densité 50 individus/m2 et Obock contre 14 semaines d’élevage à la densité de 100 individus/m2à Douda. Ces résultats révèlent une amélioration de la croissance de la palourde Amiantis umbonella à la densité de 50 individus/m2 dans les conditions d’élevage à Douda et Obock.
Sequential Therapy of Common and Plantar Warts with Salicylic Acid after Cryotherapy Versus Cryotherapy Alone: A CaseControl Study in 42 Subjects
Authors: M Milani
Published: September 2022

Background: Common wart (CW; Verruca vulgaris) is a benign cutaneous virus infection caused by human papilloma virus commonly located in the palmar and plantar regions. Warts, especially located at pressure points, could be painful, but in general they are asymptomatic. Treatment is not always necessary but when multiple lesions, pain, immunosuppression and discomfort are present therapeutic intervention could be mandatory. Chemical or physical destructions are commonly used for the treatment of CW. Cryotherapy with liquid nitrogen is a common clinician-administered treatment. The most relevant drawbacks of this procedure are the pain associated with treatment, the need of several sessions and the recurrence of new lesion. Salicylic acid (SA) applied under tape occlusion is a convenient, effective, and safe therapy of CW, even if no effective as cryotherapy. So far, there are few data regarding the efficacy and safety of the sequential treatment of CW with cryotherapy followed by a 10-day treatment course with SA. Study Design: We evaluated in a case-control study the clinical efficacy of cryotherapy alone and cryotherapy with SA in adult immunocompetent subjects with common or plantar warts.
Grammar Instruction in Communicative Language Teaching Classrooms: Student Teachers’ Perceptions
Authors: Holandyah Muhamad , Erlina Dian , Marzulina Lenny , Ramadhani Fitria Rembulan
Published: September 2022

The aim of this study was to find out the teachers and students’ perception toward grammar instruction in communicative language teaching classrooms. The participants of this study were two teachers and four students from an Islamic junior high school (Madrasah). We used a case study method to conduct this research to identify teachers and students’ perception in teaching and learning grammar instruction in communicative language teaching classroom. The data were collected by using interviews. The data were analyzed by using thematic analysis. The findings indicated that there were five indicators on student teacher’s perception; 1) grammar was a crucial component in improving English skills; 2) using classroom activities to promote communicative activities in the classroom; 3) error correction was seen as one of processes to create students in mastering materials; 4) teaching grammar instruction in CLT classroom, teachers act as motivator and facilitate all students’ need; 5) students should take part on the process of learning.
Learning Culture in Islamic Boarding Schools: The Exploratory and Confirmatory Factor Analysis
Authors: Pratama Robin , Wulandari Okky , Hendra Robi , Amanah Siti
Published: September 2022

This research was intended to test the instrument’s validity with data using exploratory factor analysis (EFA) using SPSS 23.0 to determine the structure and explore the factors in the indicator Learning Culture Variable. Confirmatory Factor Analysis (CFA) First Order was carried out to verify the factorial validity of the Learning Culture construct and to determine the nature of Learning Culture in the context of Islamic Boarding Schools in Jambi City. By using random sampling, a total of 162 samples were taken to test the quality of the instrument from 534 main respondents, namely teachers at Islamic boarding schools in Jambi City who were involved in the main research. This quantitative study used a cross-sectional survey design to analyze the factor structure of the Learning Culture variable. Quantitative data were analyzed using exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) using SPSS 23 and AMOS 18. The findings of this study are that EFA produces a similar structure from previous studies and this study. The CFA approach verified that the Learning Culture Variable questionnaire was satisfactory for Islamic boarding school teachers in Jambi City, Indonesia. This study explains that establishing validity is an important step for developing a scientific scale for measuring the questionnaire. The construct validity has substantially increased over time and through many previous studies. This scale requires further adjustments to increase the reliability and the ability to explain differences associated with constructs measured in different contexts, cultures and conditions.
Teaching English to Visually-Impaired Students: An Analysis of Teacher’s Problems
Authors: Marzulina Lenny , Erlina Dian , Holandiyah Muhamad , Harto Kasinyo , Herizal Herizal , Amrina Rizqy Dwi , Nopalia Nopalia
Published: September 2022

The aim of this study was to find out the teachers’ problems in teaching English to visually-impaired students. The participants of the study were two English teachers at one special school in Palembang, Indonesia. A qualitative research design with a case study method was applied in this research. Interviews and document analysis were conducted to gain in-depth information and understanding on the subject, while thematic analysis was used to analyze and describe the collected data. Triangulation and member checking were used to assess the trustworthiness of the research results. The results indicated that the main problems encountered by the teachers in teaching English to visually-impaired students were associated with time management, students’ attitude and behavior, lack of instructional materials and equipment, and poor classroom condition.
The Effect of Housing Conditions and Living Environment on the Health of Russian Population
Authors: Kislitsyna Olga
Published: September 2022

Poor housing - poses a serious health risk to populations around the world.
The aim of the study is to examine the impact of various aspects of housing on the health status of Russians, adjusted for demographic and socioeconomic factors that can mitigate or exacerbate the relationship between housing and health.
Comprehensive observation of living conditions of the population, conducted by Rosstat in 2018, was used as an information base for the study. The statistical analysis was carried out using multivariate logistic regression models of the SPSS package. Self-reported health and the presence of chronic diseases were used as characteristics of respondents' health / ill health. Four aspects of housing are considered: physical living conditions, stability, physical and social environment of the place of residence.
The results obtained indicate that physical living conditions have a significant impact on the health of Russians: the risk of poor health is associated with the unsatisfactory condition of the walls and roof, lack of heat; the risk of chronic diseases increases with the presence of insects (rodents), air pollution, dust, soot from the street, noise from neighbors, lack of sunlight, dampness (freezing) of the floor and walls; living in highly cramped dwellings increases the risk of ill health. It has been found that health is closely related to the type of home ownership: for those who do not own a home, the likelihood of poor health increases, and for those who live in their own home, but continue to pay mortgages for it, the risk of chronic diseases increases. In addition to the condition of the home itself, its location is an important factor in health. The most important characteristics influencing both self-esteem of health and the occurrence of chronic diseases were the inaccessibility of health services, high crime rates, prevalence of alcoholism and environmental pollution. Some gender differences have been identified.
The results obtained indicate the need for a combination of various programs and policies aimed at improving the quality standards of housing, planning the quality of the living environment.
Standard of Living Index (SLI) and Inequalities in the Rural Areas of Uttar Pradesh
Authors: Pandey Alok Kumar , Dixit Annapurna
Published: September 2022

The GDP per person in India doubled from US $ 260 in 1980 to US $ 538 in 2003. However, growth has not been evenly distributed among Indiaâ€™s various sectors, and the composition of GDP has changed. Agriculture used to be the leading sector, but its GDP share dropped from 57 per cent in 1950 to 22 per cent in 2002 and is estimated to 18.6 percent during 2006-2007. More than 65 per cent of Indiaâ€™s population is rural, and 58 per cent of the rural labour force works in agriculture. These people are mainly marginal farmers or small farmers that accounts for less than one third of the countryâ€™s total farming area. In India the diversities in economic and social development have different capacities of poverty reduction for a variety of reasons. In this study the standard of living index of a household has been classified by adding scores assigned to various items and the total score representing the SLI of the household.Â  The Lorenz curve can be obtained if we have the value of SLI for each household of the population. Broadly the SLI of a household has been classified by adding scores assigned to various items and the total score representing the SLI of the household. Though the total score of SLI has been tabulated with the help of raw data, the exact score for SLI of a household can be computed.
To the history of the publication Collection of poems by Sergey Esenin (1926): new material
Authors:   Gorky Institute of World Literature of  the Russian Academy of Sciеnces, Shubnikova-Guseva Natalya I.
Published: September 2022

n the article for the first time the history of the creation of the three-volume “Collection of poems” (1926) has been analyzed in the article based on the archival documents. The work on the proofreading of volumes given in the chronological order of the decisions taken by the editorial board of the Collection has not previously been the subject of a special academic study. The analysis shows, how D.A. Furmanov, A.K. Voronsky, I.V. Evdokimov and other employees of the State Publication House achieved the pursuance of the author’s will and kept the composition and the structure prepared by Yesenin, including in the third volume the dramatic poem “The Country of Scoundrels”.
Screen version as a variant of cultural translation: “The Queen of spades” in English
Authors:   Leningrad State University n.a. A.S. Pushkin, Demidova Olga R. ,   European University in St. Petersburg
Published: September 2022

The article based on multidisciplinary methodology of the humanities presents the definition of the concept of cultural translation, the British version of “The Queen of Spades” screened by Thorold Dickinson in 1949 analyzed as such. Dickinson’s picture is regarded on the background of preceding Russian screen versions of Pushkin’s long short story (povest’) which set various variants of its translation into the language of cinema and were adapted by Dickinson to the English cultural tradition and British ideas about Russian culture.
Review of the academic collection of V.V. Mayakovsky’s works in 20 volumes
Authors:   Gorky Institute of World Literature of the Russian Academy of Sciences, Tyurina Elena А.
Published: September 2022

The article reviews a new full scientific collection of works by V. Mayakovsky in 20 volumes, which is a new word in the study of the poet. The first four volumes were published, including all of Mayakovsky's poetic heritage. This edition has a number of significant differences from the previous 13-volume collected works (Moscow, 1955–1961): 1. More advanced composition. Agit poems not published in the collections of works; for the first time, the volume “Painting and Graphics” and five more volumes with Mayakovsky’s works of art (political and social posters, advertisements — for the first time are given not only the text to them, but also drawings); included section of notebooks, etc. 2. A new textological preparation of texts on the principles of textological science of the XXI century has been carried out — the choice of the main source of the text is made on the basis of a comparison of all existing sources of the work and takes into account the latest creative will of the author. This made it possible to correct mistakes and typos, to make reasoned amendments, to restore censorship exemptions and author's spelling and punctuation, to give a new date. 3. In a new way, without ideological determination, with the involvement of inaccessible archival materials, many new realities were commented, which became outdated and became obscure to the modern reader. The comment is several times higher than the previous one, contains literary criticism, including material from Russian abroad. The article provides an overview of the next upcoming volumes of the new academic collection of works by V. Mayakovsky
Semantic transformations of phraseological units in Russian and Slovak newspaper articles
Authors:   University of Ss. Cyril and  Methodius in Trnava, Spisiakova Andrea , Iermachkova Olga E.
Published: September 2022

The paper focuses on semantic transformations of phraseological units which are a highly effective means of attracting the attention of the recipients and creating a language game. The aim of this paper is to present and describe individual types of semantic phraseological transformations, i.e. double actualisation and dephraseologisation, their characteristic features, ways of formation, and the effects they create on the reader within a comparative analysis. The authors provide practical examples of semantic transformations of phraseological units in newspaper articles using the example of two Slavic languages — Russian and Slovak, based on which conclusions are drawn.
Sufi tradition, or Sophia in “Persian motives” by S.A. Yesenin: apophatic of a literary work
Authors:   Peoples’ Friendship University of Russia, Dudareva Marianna A. ,   Magazine “Nevecherniy Svet”
Published: September 2022

The apophatic of Russian artistic culture is the broadest object of research. Today, an ancient concept “apophatic” radiates into all research humanitarian paradigms. The subject of the article is the ways of manifestation of apophatic reality in the cycle of poems “Persian motives” by S. Yesenin. The research methodology is reduced to the use of the ontohermeneutic analysis of a literary work, which is aimed at highlighting the philosophical issues of a poetic text. Drawing parallels with Russian folklore, a fairy tale, the poetics and aesthetics of which was well known by the poet, who studied folklore from collections of folklorists and collected it, seems productive. The Russian fairy tale is characterized by an apophatic search for “another kingdom”, ideal solar earth, which is personified by the author’s topos of Bosphorus in the Yesenin cycle. The apophatic tradition is characteristic not only of Russian verbal culture; it also manifests itself in Sufism, as an esoteric trend of Islam, in which the phenomenon of an invisible “light man” is highlighted. This observation is significant in the analysis of “Persian motives”, in which the Sufi tradition was latently expressed through the semiotically important gesture of “removing the veil” from the face of the beloved, equated in the axiological sense to “removing the mantle”, familiarizing with sacred knowledge in Sufism. In the Russian version of logocentrism, the teaching of Vladimir Solovyov about Sofia, widely known among the creative intelligentsia of the Silver Age, is associated with such apophatic image of the beloved. Research into world mythology by Robert Graves points to a possible relationship between Sophia and the Black Sufi Maidens. The research results are reduced to the following conclusion: the image of the ideal lover in Yesenin’s “Persian Motives” has Sufi roots and is associated with the highest mode of love, which is achieved through an ontologically significant search for “another kingdom” characteristic of the Russian fairy tale. This cycle presents a synthesis of different cultural and literary traditions, in which an apophatic tradition can be identified at the typological level.
“Ornament is music” (On the question of the sources of S.A. Yesenin’s article “Maria’s keys”)
Authors:   Gorky Institute of World Literature of the Russian Academy of Sciences, Shubnikova-Guseva Natalia I.
Published: September 2022

The presented work expands the source base of S.A. Esenin’s theoretical article “Maria’s Keys” (1918) at the expense of previously unknown philosophical sources. Along with the ideas of representatives of the mythological school in folklore studies and the anthroposophical ideas of R. Steiner, Andrei Bely, as well as the work of N.A. Klyuev, Esenin enters into a dialogue with the positions of famous philosophers and art theorists of different eras. The initial sentence of the article “Ornament is music” deserves special attention, combining various issues of art theory into a single conceptual node. It is concluded that it is a cliche of catch phrases expressing the attitude of philosophers to various branches of art, especially popular among the German philosophers of the XVIII century, including I.V. Goethe. Based on the data of Esenin’s personal library, it is shown that the poet, who tends to the symbolic justification of art, is particularly close to Goethe’s ideas about music as a lullaby of all art and about the birth of a creative picture of the world according to nature, which were embodied in the work of the Russian poet in the “nodal ovary of nature with the essence of man”. Taking into account the experience of philosophical thought and the role of ornament in everyday folk art, Esenin puts forward an original theory of national Russian art and gives the keys to understanding the peculiarities of his own poetics.
A Global Society of Reciprocity
Authors: Wei Yifan
Published: September 2022

This essay concerns the claim that egalitarian principles of distributive justice apply within states but not between them. The analysis will rely primarily on the arguments made in Andrea Sangiovanni’s article. Due to the limit of words and attention, I shall only discuss issues of inequality of resources/wealth and focus only on Sangiovanni’s arguments on relational claims.I will first demonstrate his arguments, in relational account, how Globalist Egalitarian does not justify an obligation of distributive justice and how Internationalism, in accordance to his idea of Reciprocity, does.  Later I will demonstrate, with his logic, why global distributive justice is justified and desirable. Thus, proves the claim above wrong.
Influence of Corporate Social Responsibility Disclosure on financial performance of manufacturing companies listed on Indonesia Stock Exchange
Authors: Laksmi Ayu Chairina , Hasri Adella Puspita
Published: September 2022

This study aimed to investigate the influence of Corporate Social Responsibility Disclosure (CSRD) on companies’ financial performance which was proxied by Return on Assets (ROA), Return on Equity (ROE), and Earning per Share (EPS). The analysis was conducted on the annual reports of 31 manufacturing companies that were listed on the IDX from 2016 to 2019. A purposive sampling method was employed to select samples from the population. The data analysis was performed by using SPSS Statistics for Windows, Version 21. The results indicated that CSRD had significant positive influences on ROA and ROE, but CSRD did not have an influence on EPS. The findings of this study can be a consideration for companies’ decision making related to their CSRD which is important for their public image and profit-making activities. Investors can also benefit from the study by using CSRD as a reference in making investment decisions. Lastly, the government can use this study to evaluate the implementation of compulsory CSRD in companies in Indonesia.
Early Retrieval Problem and Link Prediction Evaluation via the Area Under the Magnified ROC
Authors: Muscoloni Alessandro , Cannistraci Carlo Vittorio
Published: September 2022

Link prediction is an unbalanced early retrieval problem, whose goal is to prioritize a small cohort of positive links on top of a list largely populated by unlabelled links. Differently from binary classification, here the evaluation focuses on how the predictor prioritizes the positive class because, in practice, a negative class does not exist. Previous studies explained that AUC-ROC is not apt for unbalanced class problems and is misleading for early retrieval problems, therefore standard AUC-ROC is not appropriate for evaluation of link prediction. However, some scholars argue that an AUC-ROC like evaluation accounting for the relative positioning of the few positive links among the vastness of unlabelled links remains a valid concept to pursue. Here we propose the area under the magnified ROC (AUC-mROC), a new measure that adjusts the standard AUC-ROC to work also for unbalanced early retrieval problems such as link prediction.
The multifaceted roles of Zinc in Cancers
Authors: Bendellaa Mohamed , Lelievre Pierre , Coll Jean-Luc , Sancey Lucie , Deniaud Aurélien , Busser Benoit
Published: September 2022

Zinc (Zn) is a trace element crucial for oxidative stress, apoptosis, the immune response, and more globally for various processes involved in cellular homeostasis. In some cancers, Zn homeostasis is dysregulated. In this review, the role of Zn in cancer and all the components associated to Zn, the use of Zn and Zn -related proteins as biomarkers and Zn-based strategies for the treatment of tumors will be described. ZIP and ZnT are proteins related to Zn metabolism in normal conditions. In cancer, the level of expression of Zn related proteins is abnormal. These Zn proteins may act as prognostic or diagnostic biomarkers, and may be helpful for detecting early-stage cancers or monitoring the course of the disease. Additionally, Zn and its pathways may also be targeted to treat cancers. Indeed, the use of metals for binding Zn cations allows to regulate the biodistribution of Zn within cells, and will control several downstream signaling pathways. Zinc may also be directly used as a therapeutic substance to improve the prognosis of cancer patients, especially with the supplementation of zinc or the use of Zn oxide nanoparticles.
Use of Human Lung Tissue Models for Screening of Drugs Against SARS-CoV-2 Infection
Authors: McAuley Alexander J , Jansen van Vuren Petrus , Mohammed Muzaffar-Ur-Rehman , Faheem Faheem , Goldie Sarah , Riddell Shane , Gödde Nathan J , Styles Ian K , Bruce Matthew P , Chahal Simran , Keating Stephanie , Blasdell Kim R , Tachedjian Mary , O'Brien Carmel M , Singanallur Nagendrakumar Balasubramanian , Viana John Noel , Vashi Aditya V , Kirkpatrick Carl M , MacRaild Christopher A , Shah Rohan M , Vincan Elizabeth , Athan Eugene , Creek Darren J , Trevaskis Natalie L , Murugesan Sankaranarayanan , Kumar Anupama , Vasan Seshadri S
Published: September 2022

The repurposing of licenced drugs for use against COVID-19 is one of the most rapid ways to develop new and alternative therapeutic options to manage the ongoing pandemic. Given the approximately 8,000 licenced compounds available from Compounds Australia that can be screened, this paper demonstrates the utility of commercially-available ex vivo/3D airway and alveolar tissue models. These models are a closer representation of in vivo studies compared to in vitro models, but retain the benefits of rapid in vitro screening for drug efficacy. We demonstrate that several existing drugs appear to show anti-SARS-CoV-2 activity against both Delta and Omicron Variants of Concern in the airway model. In particular, fluvoxamine, as well as aprepitant, everolimus, and sirolimus have virus reduction efficacy comparable to the current standard of care (remdesivir, molnupiravir, nirmatrelvir). Whilst these results are encouraging, further testing and efficacy studies are required before clinical use can be considered.
Sulfatide Deficiency, An Early Alzheimer’s Lipidomic Signature, Causes Brain Ventricular Enlargement in the Absence of Classical Neuropathological Hallmarks
Authors: Ding Lin , Palavicini Juan Pablo , Pan Meixia , Qiu Shulan , Wang Hu , Shen Qiang , Dupree Jeffrey L. , Han Xianlin
Published: September 2022

Alzheimer’s disease (AD) is a neurodegenerative disease characterized by progressive memory loss and a decline in activities of daily life. Ventricular enlargement has been associated with worse performance on global cognitive tests and AD. Our previous studies demonstrated that brain sulfatides, myelin-enriched lipids, are dramatically reduced in subjects at the earliest clinically recognizable AD stages via an apolipoprotein E (APOE)-dependent and isoform-specific process. Herein, we provided pre-clinical evidence that sulfatide deficiency is causally associated with brain ventricular enlargement. Specifically, taking advantage of genetic mouse models of global and adult-onset sulfatide deficiency, we demonstrated that sulfatide losses cause ventricular enlargement without significantly affecting hippocampal or whole brain volumes using histological and magnetic resonance imaging approaches. Mild decreases in sulfatide content and mild increases in ventricular areas were also observed in human APOE4 compared to APOE2 knock-in mice. Finally, we provided Western blot and immunofluorescence evidence that aquaporin-4, the most prevalent aquaporin channel in the central nervous system (CNS) that provides fast water transportation and regulates cerebrospinal fluid in the ventricles, is significantly increased under sulfatide-deficient conditions, while other major brain aquaporins (e.g., aquaporin-1) are not altered. In short, we unraveled a novel molecular mechanism that may contribute to ventricular enlargement in AD.
Effectiveness and Tolerability of Early Treatment with Monoclonal Antibodies against SARS-Cov-2: Results from A Real-Life Study before Omicron Surge
Authors: Scotto Riccardo , Buonomo Antonio Riccardo , Zumbo Giulia , Di Fusco Antonio , Esposito Nunzia , Di Filippo Isabella , Nobile Mariano , Pinchera Biagio , Schiano Moriello Nicola , Villari Riccardo , Gentile Ivan
Published: September 2022

Abstract Despite the lightning-fast advances in the management of SARS-CoV after 2 years of pandemic, COVID-19 continues to pose a challenge for fragile patients, who could benefit from early administration of monoclonal antibodies (mAbs) to reduce the risk of severe disease progression. We conducted a prospective study to evaluate effectiveness of mAbs against SARS-CoV-2 among patients at risk for severe disease progression, namely elderly and those with comorbidities, before the omicron variant surge. Patients were treated with either casirivimab/imdevimab, sotrovimab, and bamlanivimab/etesevimab. The rates and risk factos for clinical worsening, hospitalization, ICU admission and death (unfavourable outcomes) were evaluated. A stratified analysis according to the presence of SARS-CoV-2 IgG was also performed. Among 185 included patients, we showed low rates of unfavorable outcomes (9.2%), which were more frequent in patients with chronic kidney disease (aOR: 10.44, 95CI: 1.73-63.03; p<0.05) and basal D-dimer serum concentrations >600 ng/ml (aOR 21.74, 95CI: 1.18-397.70; p<0.05). Patients with negative SARS-CoV-2 serology at baseline showed higher C-reactive protein values compared with patients with positive serology (p <0.05) and showed a trend toward a higher admission rate to SICU and ICU compared with patients with positive serology. Our results thus showed, in a real-life setting, the efficacy of mAbs against SARS-CoV-2 before Omicron surge when the available mabs become not effective.
Blood Groups (ABO/Rh) And Sociodemographic and Clinical Profile among Patients with Leprosy in Angola
Authors: Sacomboio Euclides Nenga Manuel , Muhongo Tomásia Oliveira , Tchivango Adelino Tchilanda , Cassinela Edson Kuatelela , Silveira Silvana da Rocha , Da Costa Mauricio , Pinto de Sousa Carlos Alberto , Sebastião Cruz Sebastião , Valentim Eduardo Ekundi
Published: September 2022

Introduction: Leprosy, caused by Mycobacterium leprae is one of the oldest infectious diseases in human history and its eradication is linked to poverty control, lack of basic sanitation, the fragility of health, and education services. Objective: To evaluate the frequency of blood groups (ABO/Rh) and the sociodemographic and clinical profile of Angolan patients with Leprosy treated at the Anti-Tuberculosis and Leprosy Dispensary in Luanda, the capital city of Angola. Methodology: A descriptive, introspective, cross-sectional study with a quantitative approach was carried out with 102 patients of Luanda, in the second half of 2021. Results: Of the 102 patients included in the study, the majority belonged to the ORh+ group (51.9%), followed by the BRh+ group (27.4%) and ARh+ (18.6%), most were under 51 years of age ( 87.3%), with low education (54.9%), coming from urban areas (44.1%). As for clinical conditions, most had a multibacillary infection (93.1%), diagnosed mainly by smear microscopy (75.5%) without other infection (79.4%), some of them with complications (28.4%) and individuals with non-O blood group showed changes in the blood count. Conclusion: Leprosy seems to be common in ORh+ individuals, it continues to affect especially those residing in areas of population agglomerations and with low education, presenting itself as a multibacillary infection, where changes in the blood count are greater in non-O individuals.
Genome-Wide Association Mapping of Resistance to Warrior (-) Yellow Rust Race at the Seedling Stage in Current Central and Northern European Winter Wheat Germplasm
Authors: Shahinnia Fahimeh , Mohler Volker , Hartl Lorenz
Published: September 2022

To evaluate genetic variability and seedling plant response to a dominated Warrior (-) race of yellow rust in Northern and Central European germplasm, we used a population of 229 winter wheat cultivars and breeding lines for genome-wide association study (GWAS). A wide variation in yellow rust disease severity (based on infection types 1-9) was observed in this panel. Four breeding lines TS049 (from Austria), TS111, TS185, and TS229 (from Germany) and one cultivar TS158 (KWS Talent) from Germany were found to be resistant to Warrior (-) FS 53/20 and Warrior (-) G 23/19. GWAS identified five significant SNPs associated with yellow rust on chromosomes 1B, 2A, 5B, and 7A for Warrior (-) FS 53/20, while one SNP on chromosome 5B was associated with disease for Warrior (-) G 23/19. For Warrior (-) FS 53/20, we discovered a new QTL for yellow rust resistance associated with the marker Kukri_c5357_323 on chromosome 1B. The resistant allele G at the marker locus Kukri_c5357_323 on chromosome 1B and the susceptible allele T at the marker locus Excalibur_c17489_804 on chromosome 5B showed the largest effects (1.21 and 0.81, respectively) on the severity of yellow rust detected in Warrior (-) FS 53/20 and Warrior (-) G 23/19. Among 144 putative genes within the flanking sequence of the significant SNPs detected by GWAS, the function of the best candidate genes was determined as protein kinase activity and oxidoreductase activity. Our results provide the basis for knowledge-based resistance breeding in the face of the enormous impact of the Warrior (-) race on wheat production in Europe.
Sesión de simulación clínica en línea con avatares humanos
Authors: Tormo-Calandín Constantino , Hernández Vargas Clara Ivette , Ruíz López José Luis , Córdova Aguiar Fernando , Prats Martínez Vicente , Tapia Jurado Jesús , Del Pino Mijares María Fernanda , Vargas Campuzano José Javier , Zamudio Sánchez Teresa Vinisa
Published: September 2022

introducción

La pandemia COVID-19, ha obligado a las instituciones académicas a implantar diferentes metodologías hibridas (presencial y a distancia), la educación basada en simulación no es la excepción, esta se ha adaptado al modelo a distancia, como es la telesimulación.

Desarrollo de la experiencia de innovación

Se presenta un procedimiento de simulación en línea, con avatares humanos presentes en el escenario de simulación, que se identifican con cada uno de los alumnos en remoto, desarrollan la acción que estos indican en tiempo real, recibiendo los alumnos retroalimentación inmediata; lo que favorece  el aprendizaje significativo.

Discusión de la innovación docente

Se analizan las ventajas de distintas modalidades de telesimulación, se propugna que la simulación con avatares humanos facilita el desarrollo cognitivo, afectivo y psicomotor en los alumnos, favorece el trabajo en equipo, la interacción social; y es capaz de crear una comunidad de investigación con presencia cognitiva, social y docente.

Conclusiones

La simulación clínica con avatares humanos constituye un nuevo procedimiento en simulación en línea, que podría contribuir a mejorar la formación médica. Se propone continuar con la evidencia empírica y la investigación científica sobre este nuevo modelo de telesimulación.

Palabras clave: Telesimulación, sesión clínica, simulación avatar, habilidades.
Uso de Twitter como herramienta educativa de aprendizaje autónomo y colaborativo en el Grado de Veterinaria
Authors: Ayala-Soldado Nahúm , Mora-Medina Rafael , De la Cruz-Ares Silvia , Molina-López Ana Mª , Lora-Benítez Antonio Jesús , Moyano-Salvago Mª del Rosario
Published: September 2022

Desde el punto de vista educativo, el uso de redes sociales facilita el intercambio de información, haciéndolo más ágil y accesible y permitiendo el acceso a gran cantidad de información especializada en tiempo real. Twitter se caracteriza por su sencilla y directa forma de comunicación, permitiendo el desarrollo de habilidades comunicativas y la capacidad de síntesis. El objetivo principal de este proyecto ha sido determinar el valor de la red social Twitter como instrumento educativo de aprendizaje autónomo y colaborativo. Se creó una cuenta de Twitter para la asignatura optativa de “el Animal de Laboratorio”, perteneciente al Grado de Veterinaria (@cuartaErre). Se llevaron a cabo dos actividades: i) la gestión temporal del propio perfil por parte de distintos grupos de trabajo, y ii) el seguimiento e interacción con el perfil @cuartaErre desde cuentas individuales de cada alumno. Se evaluó mediante cuestionarios tanto la situación inicial del alumnado, como los logros finales respecto al objetivo planteado, siguiendo una metodología descriptiva. Destaca su funcionalidad como instrumento de aprendizaje autónomo, permitiendo al estudiantado reflexionar acerca de su propio proceso de aprendizaje. Se trata, además, de una metodología que fomenta el aprendizaje colaborativo, permitiendo interactuar, compartir conclusiones y establecer un reparto de tareas. Igualmente, aumenta el interés y la motivación, al igual que promueve la participación. En definitiva, se pone de manifiesto la idoneidad del uso de Twitter como herramienta educativa en un proceso de enseñanza-aprendizaje competencial como el actual.
Redes de formativas del conocimiento informacional
Authors: García Lirios Cruz
Published: September 2022

La revisión de los discursos mediáticos en torno a la formación académica, profesional y laboral con la finalidad de observar la emergencia de una agenda centrada en la apología del fenómeno fue el objetivo del presente trabajo. Se realizó un estudio documental con una selección no probabilística de fuentes indexadas a repositorios internacionales, considerando el año de publicación de 2010 a 2022 y la búsqueda por palabras claves, aunque los resultados advierten la prevalencia del emprendimiento y la innovación, la literatura también estaca a la formación docente como eje central de la calidad de los procesos y los productos de Instituciones de Educación Superior en alianzas estratégicas con organizaciones productoras del conocimiento.
El TEATRO COMO RECURSO DIDÁCTICO PARA LA MEJORA DEL RENDIMIENTO ACADÉMICO EN LA ENSEÑANZA-APRENDIZAJE DEL INGLÉS EN EL GRADO DE EEII Y DOBLE GRADO EN LA UHU
Authors: Ramos Ramos María Rocío
Published: September 2022

En las últimas décadas términos como “gamificación” y “juego serio” han inundado las investigaciones sobre educación y mejora del proceso enseñanza-aprendizaje (Borrás 2015; Cortizo 2011; Chaves 2019; Ponz & Vernet 2019). Asimismo, los “juegos de rol” han resultado un recurso periódico en la enseñanza específica de lenguas, recurriendo al teatro “como recurso de aprendizaje para la enseñanza” (López, Córdoba & Conde, 2021:1). Siguiendo a Corral (2013) el teatro en la enseñanza de una lengua extranjera, en su caso el español, supone “uno de los recursos más estudiados y explotados en el aula” (1), distinguiendo dos posturas una activa−teatro como acción− y otra pasiva como espectador−el teatro como modelo”. Partiendo además de Yan (2021), que insiste en el papel promotor del teatro en el desarrollo de este proceso de enseñanza-aprendizaje de lenguas extranjeras, este estudio propone una mejora del rendimiento académico del alumnado mediante la inserción de la representación teatral en las asignaturas de inglés del grado de EEII y Doble Grado en la UHU. Con ello se pretende conseguir además un aumento de la motivación del alumnado a través del trabajo colaborativo, que redundará igualmente en la reducción del estrés y ansiedad a la hora de expresarse en una lengua extranjera.
The supply-generated sequence: A unified sequence-stratigraphic model for closed lacustrine sedimentary basins with evidence from the Green River Formation, Uinta Basin, Utah, U.S.A.
Authors: Gearon James H. , Olariu Cornel , Steel Ronald J.
Published: September 2022

Closed lakes and oceans are stratigraphically distinct systems. However, closed-lake stratigraphy is often interpreted using conventional sequence stratigraphic concepts which were generated for marine settings. As a consequence, lacustrine stratigraphy has long been vexing and applied on an ad-hoc basis. To remedy this, we present a novel, unified sequence stratigraphic model for hydrologically closed (endorheic) basins: the Supply-Generated Sequence (SGS) Model. This model was generated to interpret our outcrop-based correlation—the largest to date at ∼ 30 km—across the Sunnyside Interval member of the middle Green River Formation in Nine Mile Canyon near Price, Utah, USA. The SGS model is based on the fundamental sedimentological and hydrodynamic differences between closed lakes and marine settings wherein the relationship between water discharge and sediment discharge is highly correlated. The SGS model divides packages of genetic lacustrine strata by bounding correlative surfaces, conformable or unconformable, separating facies and surfaces associated with low clastic supply (e.g., carbonates, mudstones, or exposure surfaces) from facies characteristic of relatively higher amounts of clastic supply (subaerial channelized sandstones, subaqueous siltstones, and pedogenic mudstones). We use the SGS model to correlate regional sequences at a higher resolution than previous interpretations and find the greatest amount of clastic deposition occurs during periods of lake-level rise, indicating that the SGSs are characteristically transgressive. Additionally, this model removes the implicit and explicit base-level assumptions of previous sequence stratigraphic models while being agnostic to the source of increased sediment discharge and therefore generalizable to other closed lacustrine settings. We use the high-resolution supply-generated sequences (meters thick) to argue for a climatic origin of the cyclic Sunnyside interval deposits based on sequence durations (40–50 kyr), and aligning sequences with recognized early Eocene transitory hyperthermal event timing and their associated climatic shifts across the region, increasing riverine discharge of sediment and water.
Spectrophotometric Analysis of Vancomycin Hydrochloride in Pure and Pharmaceutical Injections via Batch and Cloud Point Extraction Techniques
Authors: Al-ward Hind S. Al-ward , Al-Abachi Mouayed Q. , Ahmed Mohammed R.
Published: September 2022

Development of a precise and delicate reaction has been acquired for the determination of vancomycin hydrochloride using batch and cloud point extraction (CPE) methods. The first method is based on the formation of azo dye as a result of diazotized dapsone coupled with vancomycin HCl (VAN) in a basic medium. The sensitivity of this reaction was enhanced by utilizing a nonionic surfactant (Triton X-114) and the cloud point extraction technique (second method). The azo dye formed was extracted into the surfactant-rich phase, dissolved in ethanol and detected at λmax 440 nm spectrophotometrically. The reaction was investigated using both batch and CPE methods (with and without extraction), and a simple comparison between the two developed methods was made. The conditions that affect the extraction process and the sensitivity of the methods have been carefully examined. The linearity of the calibration curves was in the range of 3-50 and 0.5- 25 µg.mL-1 with limits of detection of 0.806 and 0.462 µg.mL-1 for VAN in both batch and CPE procedures, respectively. The percentage of relative standard deviation (R.S.D.%) for the two methods was better than 2.54% and 2.83%, respectively. The recommended procedures have been effectively used to assay VAN in commercial injections.
Evaluation of Some Heavy Metals, Their Fate and Transportation in Water, Sediment, and Some Biota within AL-Musayyib River, Babylon Governorate, Iraq
Authors: Salman Jasim Mohammed , Kaizal Ashwak  Falih , Kot Patryk
Published: September 2022

This study estimated seven heavy metals (Fe, Cu, Zn, Pb, Ni, Cd, Cr) in water (dissolved and particulate phase), sediments and some aquatic organisms including two species from aquatic plants (Ceratophyllum demersum&Phragmites australis); one species of clam (Psedontopeses euphratics) and two species from fish (Oreochromis aureus& Leuciscus vorax)in four sites within Mashroo AL- Musayyib channel project/ branch  of Euphrates river, Babylon , medial of Iraq . This aims to show the concentration of these elements, their fate and the mechanisms of their transmission through the food chain in this lotic aquatic system ; also in addition to examining  some physicochemical properties of river water such as water temperature (WT),air temperature (AT),pH , electrical conductivity ( EC) , salinity ,total dissolved solid ( TDS), total  solid  suspended (TSS) , dissolved oxygen (DO)  and biological oxygen demand ( BOD5) .The occurrence in heavy metals in water was found in the order in the Dissolved phase :- Zn> Fe > Cu> Ni>Pb> Cr > Cd, the zinc element recorded the highest rate in site two for spring season while the cadmium element recorded the lowest rate in site one for spring season. In the particulate phase:- Zn> Cu >Fe > Ni>Pb> Cr > Cd,  the zinc element recorded the highest rate in site two for spring season while the cadmium element recorded the lowest rate in site four for spring season. The sediment order was Zn> Cu >Fe >Pb> Ni > Cd > Cr where the zinc element recorded the highest rate in site two for spring season where as the chromium element recorded the lowest rate in site two for spring.  In aquatic plant the order was in C. demersum :Zn> Fe > Cu>Pb> Cr > Ni > Cd,  the zinc element recorded the highest rate in site four  for winter season while the cadmium element recorded the lowest rate in site one for autumn season.  In P. australis: Zn> Fe > Cu>Pb> Cd > Ni > Cr , the zinc element recorded the highest rate in site two for spring  season while the chromium  element recorded the lowest rate in site two for spring season. In clam the order was: Zn> Fe > Cu> Ni >Pb> Cd > Cr where the zinc element recorded the highest rate in site two for spring season while the chromium recorded the lowest value in site 3 through  winter 2021.In fish species (O. aureas) the order was Fe > Zn > Cu>Pb> Cr > Cd > Ni. The iron element recorded as the highest rate in site 2 in spring 2021 whilethe element that recorded the lowest rate was Ni in site 2for spring in L. vorax. The iron element recorded the highest rate in site one for summer season where as the Nickel was recorded a lower value in site four in spring2021.