bluuebunny/crossref_metadata_2025 huggingface dataset:
Bevacizumab Treatment for Choroidal Neovascularization Associated with Adult-Onset Foveomacular Vitelliform Dystrophy
Authors: Tiosano Liran , Jaouni Tareq , Averbukh Edward , Grunin Michelle , Banin Eyal , Chowers Itay
Published: July 2014

Purpose

To evaluate choroidal neovascularization (CNV) associated with adult-onset foveomacular vitelliform dystrophy (AOFVD) and its response to bevacizumab therapy.

Methods

Demographics, clinical characteristics, response to bevacizumab therapy, and central foveal thickness (CFT) were retrospectively assessed in 11 eyes with CNV associated with AOFVD. Sixty consecutive patients with neovascular age-related macular degeneration (AMD) were compared to the patients with AOFVD for all clinical characteristics and responses evaluated.

Results

The mean (±SD) initial logMAR visual acuity (0.7 ± 0.8 vs. 1 ± 0.75), age at onset, number of bevacizumab injections (12.4 ± 10.4 vs 9 ± 6.7), and final logMAR visual acuity (0.87 ± 0.7 vs 1 ± 0.85) were similar between AOFVD and AMD. The mean CFT in AOFVD was reduced from 418 ± 144 μm to 330 ± 64 μm following treatment (p = 0.03). At the final examination, visual acuity had improved in 3 eyes, stabilized in 1 eye, and was reduced in 7 of the AOFVD eyes examined.

Conclusions

Bevacizumab therapy for AOFVD-associated CNV resulted in reduced foveal thickness, but a guarded visual outcome was still found, due to progression of the vitelliform lesions.
Evaluation of Cytologic Specimens Obtained during Experimental Vitreous Biopsy Using B-Cell Lymphoma Line
Authors: Jiang Tingting , Zhao Zhenyang , Chang Qing
Published: July 2014

Purpose

To investigate the role of vitrectomy in the diagnosis of intraocular lymphoma by evaluating the effects of aspiration pressure and cut rate on cell viability and diagnostic yield.

Methods

Cells of the human Burkitt lymphoma cell line Namalwa were processed by 20-G vitrectomy under 2 different aspiration pressures and at different cut rates. Some samples were divided into high and low aspiration pressure groups and were then divided into 6 subtypes according to the different cut rates (0, 300, 600, 800, 1500, or 2500 cuts per minute [cpm]). Other samples were treated with dexamethasone sodium phosphate for 48 hours with or without further culturing in cell culture media afterward. The cell viability in each subtype group was determined using trypan blue staining and the Cell Counting Kit–8.

Results

The number of viable cells was reduced with increasing cut speed under high aspiration pressure. Cell viability began to decrease at 600 cpm and was lowest at 2500 cpm. Exposure to dexamethasone sodium phosphate induced destruction of cellular structure and a significant reduction in cell viability. However, cell viability could be recovered with further culture in cell culture media for 1 week.

Conclusions

A cut rate of 600 cpm or less is recommended during diagnostic vitrectomy to confirm a clinical suspicion of primary intraocular lymphoma. Corticosteroid treatment can lower the diagnostic yield due to reduced cell viability and damaged cellular structure.
Full-Thickness Macular Hole after Lamellar Macular Hole Surgery: A Case Report
Authors: Dutra Medeiros Marco , Alkabes Micol , Nucci Paolo , Branco João
Published: July 2014

Purpose

To describe a case of full-thickness macular hole (FTMH) after vitrectomy for lamellar hole (LH).

Methods

Case report.

Results

The authors report a patient with progressive visual loss secondary to LH who developed FTMH following a vitrectomy repair. The postoperative findings as well as the clinical course after the second surgical approach are described.

Conclusions

Surgeons should be aware of this complication following LH surgical approach.
Correlation of Intraocular Pressure with Central Corneal Thickness in Premature and Full-Term Newborns
Authors: Karahan Eyyup , Zengin Mehmet Ozgur , Tuncer Ibrahim , Zengin Neslihan
Published: July 2014

Purpose

To evaluate the relation of central corneal thickness (CCT) and intraocular pressure (IOP) in preterm and full-term newborns.

Methods

The study included preterm infants who were admitted to the neonatal intensive care unit. A group of consecutive full-term newborns served as control group. Linear and multiple regression analysis were carried out to assess the association of IOP with sex, gestational/postconceptional age, birthweight, mean oxygenation time, stages of retinopathy of prematurity (ROP), and CCT. Linear and multiple regression analysis were also carried out to assess the association of CCT with sex, gestational/postconceptional age, birthweight, mean oxygenation time, and stages of ROP.

Results

Mean IOP was 17.5 ± 2.1 mm Hg in premature newborns and 16.3 ± 1.9 mm Hg in full-term newborns (p = 0.001). Mean CCT was 576.5 ± 16.8 µm in premature newborns and 562.7 ± 18.5 mm in full-term newborns (p = 0.000). Intraocular pressure was not correlated with CCT in preterm infants. Intraocular pressure was moderately correlated with CCT in full-term infants. Sex, postconceptional age at birth and at measurement, age after birth at measurement, birthweight, mean oxygenation time, and stage of ROP were not related to IOP. Central corneal thickness was not correlated with any parameter.

Conclusions

Our results showed that the CCT does not affect IOP significantly in preterm infants. More prospective studies are needed for determining the effect of CCT and other ocular and systemic factors on IOP in preterm infants.
Evaluation of Octopus Polar Trend Analysis for Detection of Glaucomatous Progression
Authors: Holló Gábor , Naghizadeh Farzaneh
Published: July 2014

Purpose

To investigate the clinical usefulness of Polar Trend Analysis (PTA) of the Octopus Field Analysis software for detection of glaucoma progression in medically treated glaucoma.

Methods

One eye each of 52 participants underwent Octopus Normal G2 perimetry and imaging with the RTVue-100 optical coherence tomograph at 6-month intervals (median follow-up 5 years). The eyes were classified as progressors or nonprogressors with PTA, which graphically presents pointwise linear regression analysis of focal defect at the corresponding nerve fiber angle at the disc margin. Polar Trend Analysis progression was defined as more than 1 significantly progressing test point location per sector. Progression of the retinal nerve fiber layer thickness (RNFLT) and ganglion cell complex (GCC) thickness parameters were evaluated with linear regression analysis.

Results

Seventeen eyes were classified as PTA progressors (all in the inferotemporal or superotemporal areas or in both), and 35 eyes as nonprogressors. Frequencies of statistically significant RNFLT and GCC progressions did not differ significantly between the groups for any peripapillary area (p>0.05 for all comparisons). Significant inferior average RNFLT progression occurred in 50% of the PTA progressor eyes. Long-term measurement variability during the follow-up period was significantly higher in the PTA progressor group for inferior and superior GCC thickness and inferior average RNFLT (p<0.001 for all comparisons).

Conclusions

In glaucoma, PTA may indicate glaucomatous progression earlier than linear regression analysis of the RNFLT and GCC parameters. It may already draw attention to glaucomatous progression when the alteration of the corresponding structural parameters is represented only by increased long-term variability.
Comparison of two Endovascular Treatments of a Stenosed Arteriovenous Fistula: Balloon-Angioplasty with and without Stenting
Authors: Decorato Iolanda , Kharboutly Zaher , Legallais Cécile , Salsac Anne-Virginie
Published: July 2014

Purpose

Arteriovenous fistulas (AVFs) are created in patients to enable a permanent vascular access for hemodialysis. The AVF causes changes in the hemodynamic conditions leading to possible complications, stenoses being the most common one. Our objective was to compare the effect of treating the stenosed AVF by balloon-angioplasty, whether followed or not with stenting.

Methods

We considered an AVF presenting an 60% arterial stenosis and simulated the two endovascular treatments using an implicit approach. We then simulated the fluid-structure interactions (FSI) within (i) the patient-specific stenosed AVF, (ii) the AVF after angioplasty, and (iii) the AVF after angioplasty plus stenting with ANSYS Workbench.

Results

We show that a self-expandable stent does not modify the curvature of the vessel after angioplasty; it only increases the local Young modulus of the stented wall by an order of magnitude. The results of the FSI simulations indicate that the two treatments induce the same hemodynamic conditions: they both reduce the pressure difference across the stenosis, while maintaining the flow distribution downstream of the stenosis. The venous flow rate that has to be guaranteed for hemodialysis is unaltered. Thanks to its large axial flexibility, the self-expandable stent causes at maximum a three-fold increase in the internal wall stresses at peak systole as compared to angioplasty alone.

Conclusions

By maintaining the vessel lumen shape over time, the stent is likely to reduce the risk of restenosis that can otherwise occur after balloon-angioplasty because of the viscoelastic recoil of the vessel.
Improving Arterial Pulsatility by Feedback Control of a Continuous Flow Left Ventricular Assist Device via in Silico Modeling
Authors: Bozkurt Selim , van de Vosse Frans N. , Rutten Marcel C.M.
Published: July 2014

Purpose

Continuous flow left ventricular assist devices (CF-LVADs) generally operate at a constant speed, which causes a decrease in pulse pressure and pulsatility in the arteries and allegedly may lead to late complications such as aortic insufficiency and gastrointestinal bleeding. The purpose of this study is to increase the arterial pulse pressure and pulsatility while obtaining more physiological hemodynamic signals, by controlling the CF-LVAD flow rate.

Methods

A lumped parameter model was used to simulate the cardiovascular system including the heart chambers, heart valves, systemic and pulmonary arteries and veins. A baroreflex model was used to regulate the heart rate and a model of the Micromed DeBakey CF-LVAD (Micromed Technology, Houston, TX, USA) to simulate the pump dynamics at different operating speeds. A model simulating the flow rate through the aortic valve served as reference model. CF-LVAD operating speed was regulated by applying proportional-integral (PI) control to the pump flow rate. For comparison, the CF-LVAD was also operated at a constant speed, equaling the mean CF-LVAD speed as applied in pulsatile mode.

Results

In different operating modes, at the same mean operating speeds, mean pump output, mean arterial pressure, end-systolic and end-diastolic volume and heart rate were the same over the cardiac cycle. However, the arterial pulse pressure and index of pulsatility increased by 50% in the pulsatile CF-LVAD support mode with respect to constant speed pump support.

Conclusions

This study shows the possibility of obtaining more physiological pulsatile hemodynamics in the arteries by applying output-driven varying speed control to a CF-LVAD.
Validation and Calibration of an Electrical Analog Model of Human Liver Perfusion Based on Hypothermic Machine Perfusion Experiments
Authors: Debbaut Charlotte , Monbaliu Diethard R.L. , Segers Patrick
Published: July 2014

Purpose

Hypothermic machine perfusion (HMP) is reviving as a better preservation method for donor livers than the golden standard of cold storage, but still faces challenges such as the risk for endothelial damage and flow competition between the arterial and portal venous inflow. Therefore, we previously developed an electrical analog model to investigate the effect of HMP settings on the human liver hemodynamics. While the model provided plausible results, it is based on a number of assumptions and its performance was never subjected to experimental validation. To this end, we present a new methodology to validate and calibrate this model to a specific liver.

Methods and Results

HMP experiments were performed to capture the perfusion behavior of a human liver during varying perfusion settings. Simultaneous pressure and flow signals were acquired at the hepatic artery, portal vein, and vena cava inferior. The calculation of hydraulic input impedances enabled reduced Windkessel models to be fitted to the global hepatic perfusion properties as an intermediate step. Based on these Windkessel models, the extended electrical analog model was calibrated to the specific available liver. Results revealed that literature values of one of the critical model parameters (wall viscoelasticity) are a few orders of magnitude off, having important consequences for simulated (pulsatile) hemodynamic variables.

Conclusions

A novel methodology, based on HMP experiments, signal processing and unconstrained nonlinear optimization was developed to validate and calibrate the liver-specific extended electrical model. Future research may focus on extending this approach to other applications (e.g. liver pathologies such as cirrhosis).
Peripheral and Endometrial Dendritic Cell Populations during the Normal Cycle and in the Presence of Endometriosis
Authors: Maridas David E. , Hey-Cunningham Alison J. , Ng Cecilia H.M. , Markham Robert , Fraser Ian S. , Berbic Marina
Published: July 2014

Background

Dysfunctional immune response may be implicated in endometriosis pathogenesis, and dendritic cells (DC) may play greater roles in this response than previously recognized. This study set out to evaluate peripheral blood and endometrial DC population changes in the presence and absence of endometriosis pathology.

Methods

Endometrial (n = 83) and peripheral blood samples (n = 30) were subjected to immunohistochemical techniques and flow cytometry, respectively, to assess DC populations in women with and without endometriosis. Three circulating DC subsets (MDC1, MDC2 and PDC, expressing CD1c, CD303 and CD141), and late-stage mature endometrial DCs (using DC-LAMP antibody) were investigated.

Results

A highly significant reduction in CD1c intensity on MDC1 populations in peripheral blood was observed between normal cycle proliferative and menstrual phases (p = 0.025), but not in women with endometriosis, in whom CD1c intensity was markedly increased at the time of menstruation (p = 0.05). A significant reduction in peripheral blood MDC2 (p = 0.016) and apparent reduction in endometrial DC-LAMP+ DC (trend, p = 0.062) were observed in women with endometriosis compared with controls, consistent with our preliminary DC data.

Conclusions

Cyclical variation in endometrial and circulating DC populations appears to be crucial during normal menstrual cycles and in the establishment of pregnancy. In endometriosis, circulating and endometrial DC populations are significantly dysregulated at a number of levels, and are likely to contribute to inefficient immunological targeting of endometrial fragments shed at menstruation, facilitating their survival and establishment of endometriosis.
Coexistence of Polycystic Ovary Syndrome and Endometriosis in Women with Infertility
Authors: Holoch Kristin J. , Savaris Ricardo F. , Forstein David A. , Miller Paul B. , Higdon H. Lee , Likes Creighton E. , Lessey Bruce A.
Published: July 2014

Purpose

The aim of this study was to investigate if there is a higher incidence of endometriosis in patients with polycystic ovary syndrome (PCOS), compared with normal fertile controls.

Material and methods

Women with PCOS according to Rotterdam criteria, with infertility and/or pelvic pain, were identified (n = 104), and together with fertile women seeking bilateral tubal ligation (n = 111), they were submitted to laparoscopy at the Greenville Hospital System or the University of North Carolina at Chapel Hill. A biopsy was performed in 40 patients with PCOS to confirm or not endometriosis.

Results

Age was similar in both groups (control: 29.7 ± 0.5 years; PCOS: 29.6 ± 0.4). The incidence of suspected endometriotic lesions in controls and PCOS patients was 12.6% (95% confidence interval [95% CI], 7.6%-20%) and 74% (95% CI, 64.8%-81.5%), respectively; with an odds ratio of 19.7 (95% CI, 9.6-40.2) of finding endometriosis in PCOS (p<0.0001). Our results were similar when endometriosis was confirmed by pathology report. Of the PCOS patients with endometriosis, 76% had endometriosis stage I or II, according to the revised American Society for Reproductive Medicine criteria.

Conclusions

In this case-control study, a significant association between endometriosis and women with PCOS with pelvic pain and/or infertility was found. The majority of endometriotic lesions (76%) were stage I or II.
Obstetric Outcomes in Patients Treated for Deep Pelvic Endometriosis
Authors: Saccardi Carlo , Borghero Angela , Gizzo Salvatore , Codroma Anna , Perini Francesca , Luisi Stefano , Litta Pietro
Published: July 2014

Purpose

The aim of this study was to assess obstetric outcomes and symptoms during and after pregnancy in women submitted to surgical treatment for deep pelvic endometriosis.

Methods

We evaluated 123 women who underwent surgery for severe deep pelvic endometriosis-related symptoms. Interventions were excision of rectovaginal septum nodule with or without rectal or vaginal resection, or excision of nodule of uterosacral ligaments. On the basis of pregnancy desire, patients were submitted to a telephone interview and asked if there had been a pregnancy and its outcome. They were also asked to describe their pain symptoms before, after and during the pregnancy.

Results

From the 123 patients, we selected 43 women desiring pregnancy after surgery, who answered the telephone interview. Twenty-four patients (55.8%) got pregnant. We recorded 34 pregnancies a mean 21.8 ± 17.9 months after surgery. In the group of 25 full-term pregnancies, 14 women (56%) had a vaginal delivery without complications, and 11 (44%) underwent a cesarean section. In only 3 cases, was the indication of cesarean section related to previous surgery. Seventy-one percent of women treated without rectal or vaginal resection delivered vaginally. We also registered 1 case of uncomplicated vaginal delivery in a patient with vaginal resection and another 1 in a patient with rectal resection. In the patients who complained of pain before pregnancy, we observed a resolution of pain symptoms during pregnancy, but after delivery these symptoms reappeared.

Conclusions

In patients submitted to surgery for deep pelvic endometriosis, even in cases of vaginal or rectal resection, a cesarean section is not always mandatory.
An Investigation of the Relationship between Pelvic Pain and Density of Nerve Fibers in Peritoneal Lesions of Endometriosis
Authors: Maharajaa Sri P.K. , Black Kirsten I. , Manconi Frank , Ng Cecilia H.M. , Hey-Cunningham Alison , Fraser Ian S. , Berbic Marina
Published: July 2014

Purpose

Endometriosis is a gynecological disease often characterized by severe pelvic pain, including perimenstrual and intermenstrual pain and dyspareunia. Sensory nerve fibers within peritoneal lesions have previously been shown to contribute to generation of pain in endometriosis; however, their association with different types of pelvic pain is currently uncertain.

Methods

Peritoneal endometriotic lesions (n = 30) were sectioned and stained immunohistochemically with protein gene product 9.5 (PGP 9.5; pan-neuronal marker), neuropeptide Y (NPY; sympathetic), vasoactive intestinal polypeptide (VIP; parasympathetic), substance P (SP; sensory) and nerve growth factor (NGF) to identify nerve fibers and neurotrophin levels. Densities were assessed within stroma of the lesions and in the adjacent peritoneum. Pelvic pain scores were obtained using a visual analogue scale (VAS), and correlation analysis was performed.

Results

Increased density of nerve fibers was observed within the stroma of lesions. NGF expression was significantly increased in glandular epithelium, compared with stromal regions (p = 0.026) and correlated inversely with menstrual pain scores (p = 0.05). Sympathetic nerve fiber density (NPY) in stroma showed a significant positive correlation with intensity of menstrual pain (p = 0.04). Parasympathetic nerve fiber density (VIP) also showed a strong trend toward a positive correlation with menstrual pain intensity (p = 0.056).

Conclusions

There is increased neurogenesis in the stromal region. Innervation of lesions correlates to intensity of menstrual pain. NGF in glandular epithelium may promote growth of nerve fibers into the core of lesions; however, the inverse correlation between NGF expression in glandular epithelium and menstrual pain indicates that mechanisms of pain generation in endometriosis are complex.
Endometrioid Adenocarcinoma Arising from Intestinal Endometriosis
Authors: Nasu Kaei , Okamoto Mamiko , Kawano Yukie , Hirakawa Tomoko , Yada Naomi , Kashima Kenji , Narahara Hisashi
Published: July 2014

Purpose

Gastrointestinal involvement of endometriosis may exist in up to 37% of women suffering from endometriosis, but malignant transformation of intestinal endometriosis is extremely rare. In this case report, we present a case of endometrioid adenocarcinoma arising from 2 different large bowel endometriotic sites, with a review of the reported cases of epithelial malignancies developed in gastrointestinal endometriosis.

Case

A 33-year-old nulligravid Japanese woman was admitted for the evaluation of massive ascites. The patient had undergone a laparoscopic bilateral cystectomy for bilateral endometriomas 8 years before. At laparotomy, we found massive serous ascites, diffuse peritoneal endometriotic lesions, edematous gastrointestinal tract with small surface nodules, stenosis of the sigmoid colon and firm and thick peritoneum. No endometriotic or tumorous lesions were found in the genital tract. The patient underwent a resection of the sigmoid colon, partial resection of the transverse colon, partial omentectomy and multiple biopsies of the peritoneum and ovaries. On the histologic examination, benign endometriosis, atypical hyperplasia and grade 1 endometrioid adenocarcinoma were found to be present in the transverse and sigmoid colon. Subsequently, the patient was treated with chemotherapy consisting of paclitaxel and carboplatin under a diagnosis of endometrioid adenocarcinoma arising in the intestinal endometriosis. The patient is well without evidence of disease 26 months following the surgery.

Conclusions

The tumors arising from intestinal endometriosis can clinically and pathologically mimic primary neoplasms of the gastrointestinal tract. Recognition of these lesions is important because primary gastrointestinal neoplasms are managed differently from those arising in endometriosis, and these differences may have significant clinical implications.
Endometriosis: Does Surgery Offer Long-Term Improvement in Quality of Life?
Authors: Farfaras Athanasios , Pierrakos George , Pateras Ioannis , Skolarikos Panagiotis , Wen Shi-Wu , Sarris Markos
Published: July 2014

Introduction

Endometriosis is a common, estrogen-dependent, benign disease that affects women of reproductive age. Endometriosis frequently presents with pain and can result in infertility. The symptoms of the disease have a negative impact on physical and mental aspects of life, contribute to reduction of social contacts and lead to a significant reduction in quality of life. In this study, we investigated quality of life of patients with endometriosis. Moreover, we examined whether surgical management could be beneficial for those patients in terms of improving quality of life.

Material and methods

In this prospective study, we included patients undergoing gynecological operations due to endometriosis-associated problems between 2008 and 2014. All patients were assessed preoperatively and 30 months postoperatively. The survey form chosen to achieve the aims of the study was the Greek version of SF-36.

Results

The results showed that both physical and mental health were highly compromised in patients affected by endometriosis, and surgical management significantly improved patients’ quality of life, as all of the SF-36 scores were higher postoperatively (p<0.05).

Discussion

Endometriosis represents an important medical problem in women, with a high impact on their quality of life, and surgical management can reverse the impact of endometriosis on patients’ health and restore their quality of life.
A Single Institution Experience of Seven Hundred Consecutively placed Peripherally Inserted Central Venous Catheters
Authors: Sainathan Sandeep , Hempstead Margaret , Andaz Shahriyour
Published: July 2014

Introduction

Peripherally inserted central venous catheters (PICCs) are being increasingly placed at the bedside by trained vascular access professional such as nurses. This is to increase the availability of the service, for cost containment, and to reduce the workload on the interventional radiologist. We describe a single institution experience with over 700 PICC lines placed by trained nurses at the bedside and determine the success rate, malposition rate of the PICC line, degree of support needed from the Interventional radiologist, and factors affecting a successful placement of a PICC line by the nurses.

Methods

Seven hundred and five PICC lines were placed at the South Nassau Communities hospital between July 2011 and November 2012 by trained vascular access nurses with interventional radiology backup. Bedside ultrasound was used for venous access, an electromagnetic catheter tip detection device was used to navigate the catheter into the desired central vein and catheter tip position was confirmed using a portable bedside chest X-ray.

Results

The nurses, with a malposition rate of 3.8%, successfully placed 91.6% (646/705) catheters. Interventional radiology support was needed for 59 cases (8.4%) and 17 cases (2.4%) for failed placement and catheter malposition adjustment, respectively. Risk factor such as presence of pacemaker wires and multiple attempts at insertion were factors predictive of an unsuccessful placement of a PICC line by the nurses.

Conclusions

Bedside placement of PICC line by trained vascular nurses is an effective method with a high success rate, low malposition rate and requires minimal support from interventional radiology.
Initial Experience with the Gore® Acuseal Graft for Prosthetic Vascular Access
Authors: Tozzi Matteo , Franchin Marco , Ietto Giuseppe , Soldini Gabriele , Carcano Giulio , Castelli Patrizio , Piffaretti Gabriele
Published: July 2014

Purpose

The purpose of this study is to report the short-term results of the Gore® Acuseal graft for prosthetic vascular access (pVA) in patients with end-stage renal disease on hemodialysis.

Methods

Between October 2011 and October 2013, all the consecutive patients who underwent implantation of a new expanded Polytetrafluoroethylene (ePTFE) tri-layer graft were included in the study. Primary and secondary patency rate, time to first cannulation, and complications were recorded. Follow-up was performed at 1, 3, 6, and 12 months after the intervention.

Results

Thirty ePTFE tri-layer heparin bonded grafts were implanted in 18 males and 12 females. The graft configuration was radial-basilic (n=12, 40%), brachial-basilic (n=10, 33.3%), femoro-femoral (n=3, 10.0%), radial-cephalic (n=2, 6.7%), radial-antecubital forearm (n=2, 6.7%), and brachial-axillary (n=1, 3.3%). No patient was lost during a mean follow-up time of 6.3±5.9 months (range, 1-24; median, 5). Mean time to first cannulation was 2.4±1.2 days (range, 1-15). Primary functional patency rate was 68.0% ± 10 at 6 and 12 months. Secondary patency rate was 93.3% ± 6 at 6 and 12 months. Pseudoaneurysm, bleeding, seroma, or graft infection was never observed.

Conclusions

In our experience, the Gore® Acuseal graft was useful and safe. Early cannulation was always performed, and structural complications did not occur. Primary functional and secondary patency rate are satisfactory in the short term.
Leaf-litter microfungal community on poor fen plant debris in Torfy Lake area (Central Poland)
Authors: Wilk Mateusz , Banach Agnieszka , Pawłowska Julia , Wrzosek Marta
Published: July 2014

The purpose of this study was to initially evaluate the species diversity of microfungi growing on litter of 15 plant species occurring on the poor fen and neighbouring area of the Torfy Lake, Masovian voivodeship, Poland. The lake is located near the planned road investment (construction of the Warsaw southern express ring road S2). The place is biologically valuable as there are rare plant communities from Rhynchosporion albae alliance protected under the Habitats Directive adopted by the European Union. On the examined plant debris 73 taxa of fungi were recorded (3 basidiomycetes, 13 ascomycetes, 2 zygomycetes, 43 anamorphic ascomycetes, 12 unidentified). Two of them, Dicranidion sp. and Wentiomyces sp. are presented here as new to Poland. Among the plant species examined, the litter of Rhododendron tomentosum harbored the highest number of fungal taxa (16). The highest percents of substrate-specific microfungi (i.e. recorded only on one plant species) was noted on R. tomentosum (81.3 %), and Pteridium aquilinum (75%). It is emphasized that the lake area should be protected not only because of rare plant community but also because of the uniqueness and diversity of mycobiota.
New localities of Protostropharia alcis (Basidiomycota, Agaricales) in Poland
Authors: Halama Marek , Kudławiec Barbara
Published: July 2014

The present paper provides new records of Protostropharia alcis in Poland. So far this species was known in the country only from several latest localities in the Biebrza National Park (Biebrza Basin) and the Kampinos National Park (Warsaw Basin). The new localities are situated in the Wigierski National Park (the East Sudetian Lake District) and in the north-western slope of Mt Wierzejska (the Holy Cross Mountains), where P. alcis was collected on dung of herbivores (eurasian elk and red dear) within several types of forest communities. All specimens of P. alcis were collected in recent years, from late September to early October, in the period 2012-2013. A full description and illustration of P. alcis based on gathered collections are given. Its delimitation, the knowledge of its ecology, general distribution, and threat is also briefly discussed. Based on the new and known distribution data for P. alcis in Poland, its red list category is proposed.
Leucocoprinus lilacinogranulosus (Henn.) Locq. in Poland
Authors: Gierczyk Błażej , Dubiel Grzegorz
Published: July 2014

The paper presents the first finding of Leucocoprinus lilacinogranulosus in Poland, the rare, exotic fungus, sporadically found in Europe. The species was found indoors, on soil in terrarium. A description based on the specimens from Poland as well as photographs and microcharacter drawings are presented.
Flammulina ononidis – first record in Poland
Authors: Łuszczyński Janusz , Łuszczyńska Bożena , Tomaszewska Agnieszka , Sobaś Kinga , Kostrzewa Małgorzata , Grudzień Katarzyna
Published: July 2014

The authors present a first record of Flammulina ononidis in Poland. This species was characterized in respect of macro- and micromorphological features, which were illustrated with the original figures and photographs. The habitat conditions of the recorded site were also described. A short discussion concerning the similar species and the ecology and threats of presented fungus species is provided.
THE LANGUAGE OF (“ANALYTIC”) PHILOSOPHY
Authors: Rodriguez-Pereyra Gonzalo
Published: July 2014

This note argues that research in Analytical Philosophy broadly conceived should be published exclusively in English. Reasons are given for this and the thesis is defended from eleven objections.
FILOSOFÍA ANALÍTICA EN AMÉRICA LATINA
Authors: Tomasini Bassols Alejandro
Published: July 2014

En este artículo diagnostico y rechazo la tesis de que el lenguaje de la filosofía analítica es el inglés. Para ello, realzo el carácter cultural de los productos filosóficos (teorías, tesis) y argumento que su utilidad está esencialmente vinculada a sus respectivos contextos de producción. Enfatizo la importancia de la fi losofía en conexión con las atividades científi cas, políticas, etc., locales. El principal blanco de mi trabajo es la idea, en gran medida propiciada por la globalización y el coloniaje cultural contemporáneos, de que hay básicamente un único modo de hacer fi losofía analítica, que ésta debería practicarse em un idioma en particular, y que dicho modelo se debe importar e imponer en los países de América Latina en donde se pretenda hacer filosofía seriamente. Ilustro rapidamente el rotundo fracaso de esta posición filosófica mediante un ejemplo de filosofía política.
GEOFILOSOFÍA DE LA CIUDAD PARA PENSAR MÁS ALLÁ DEL ORGANISMO
Authors: Landaeta Mardones Patricio , Espinoza Lolas Ricardo
Published: July 2014

En el presente artículo se investiga acerca de una comprensión “anorgánica” de la ciudad desde la idea de geofilosofía de Deleuze y Guattari, la concepción política de Jacques Rancière, y de la concepción del cuerpo de Zubiri. La fi gura del organismo domina la historia de la metafísica y, por ende, la comprensión arquitectónica y política de la ciudad. Frente a esto pretendemos investigar, en primer lugar, la diferencia entre dos comprensiones y usos del espacio: “espacio liso” y “espacio estriado”, y, en segundo lugar, la diferencia entre “procesos de sujeción” y “producción de subjetividad”. Tales ideas están repensadas desde una concepción del cuerpo que no es orgánica sino eminentemente somática y de actualidad en diferencia. La función de la idea de organismo en arquitectura, persigue la producción de identidades. Frente a ésta, los usos y la ocupación del espacio presentan la posibilidad de una “producción de sí” corporal, sentando la heterogeneidad como forma social de construcción de la ciudad, dislocando aquelorden impuesto homogéneo. Con el fin de proponer una arquitectura de la dislocación, presentamos el trabajo de Gordon Matta Clark, trabajo donde deshacer las formas del organismo implica experimentar con un devenir corporal de la ciudad.
FILOSOFIA COMO CIÊNCIA OU CULTURA PÓS-FILOSÓFICA: AS CONTENDAS ENTRE O PRAGMATISMO E O NEOPRAGMATISMO
Authors: Magalhães do Nascimento Edna
Published: July 2014

Com a publicação da obra "Philosophy and the Mirror of Nature" ("Filosofia e os Espelho da Natureza"), Rorty passa a ser criticado pelos intérpretes do pragmatismo clássico e comentadores de John Dewey. Estes críticos consideram que enquanto o pragmatismo clássico é uma tentativa de entender e criar uma estrutura nova que legitime a investigação científica, o pragmatismo de Rorty se afirma como um abandono da própria tentativa de aprender mais sobre a natureza e sobre as condições de adequação da investigação. Dewey nunca virou totalmente as costas à metafísica, que está presente particularmente em "Experience and Nature". Contudo, Rorty pretende encontrar em Dewey uma antecipação de sua própria visão de filosofia. Dessa maneira, deliberadamente, Rorty separa o Dewey “bom” do “mau” e considera inadequada a publicação de livro de Dewey "Experience and Nature". Nesse artigo, vamos nos concentrar nas críticas formuladas por Thelma Lavine, James Gouinlock e David Hall sobre a pertinência de falarmos em continuidade do pragmatismo no neopragmatismo de Rorty. Esta escolha teve como critério a maneira como esses autores se esforçam para recuperar a originalidade do pensamento do pragmatista pioneiro, não aceitando, sobretudo, uma interpretação que não reconheça na obra dele uma dimensão simultaneamente metafísica e epistêmica. Por fim, apresentamos a nossa interpretação que consiste em considerar que o Dewey de Rorty não é uma boa hipótese porque nega a dimensão cientista do pragmatista clássico e superdimensiona seu historicismo, deixando de considerar que o pragmatismo deweyano tem uma dimensão historicista e cientista ao mesmo tempo e sua metafísica é distinta das metafísicas clássicas, segundo a qual conceituo de metafísica empírica.
Contrapontos com relação à moralidade em Freud e Winnicott
Authors: Soares Santos Eder
Published: July 2014

O objetivo deste artigo é mostrar que a moralidade para Freud está determinada por um aparelho psíquico que tem por função justamente reprimir a única coisa que no homem apontaria para uma liberdade de ação, a saber: o desejo. O problema é que se todos os homens decidissem realizar todos os seus desejos, não haveria, para Freud, a possibilidade da civilização. Não haveria espaço nas teorias psicanalíticas para se pensar uma moralidade não determinada filogeneticamente? Tentarei apresentar como contraponto uma possibilidade de resposta a essa questão com a teoria psicanalítica de Winnicott.
Psicanálise e direitos humanos: o estatuto do ódio e o sujeito LGBT
Authors: N. de Oliveira Sidney , A. Gaiguer Giani
Published: July 2014

Este trabalho é um estudo sobre a manifestação da violência pelo recorte da homofobia com sujeitos LGBTs. Adentrou-se a obra freudiana (1905 a 1925), objetivando apreender, pela luz da psicanálise, a condição subjetiva do sujeito em relação à sexualidade. O ponto central da pesquisa foi alcançado pelo desenho do que se denominou estatuto do ódio, que foi composto com elementos primordiais da constituição do sujeito. O estatuto denuncia o enlace destrutivo ao outro, aqui representado pelo sujeito LGBT, denuncia uma manifestação do conteúdo arraigado no inconsciente, que alcança o fim último de um gozo do ódio caracterizado pela discriminação preconceituosa e cruel. Nessa perspectiva, destacou-se a necessidade de se construir urgentemente uma realidade social mais justa, mais bem alicerçada sobre o conhecimento científico, ético e político. Abordou-se, por fim, o enfrentamento desse ódio por uma educação emancipadora em direitos humanos comprometida com projetos de reconhecimento e de valorização da diversidade, com vistas à cidadania, minimização da opressão sociopolítica e manejo de conflitos para uma não violência.
Discursos da inclusão escolar: modos de moralizar, modos de humanizar
Authors: Corrêa Henning Paula , Lockmann Kamila
Published: July 2014

O presente artigo pretende colocar sob suspeita alguns discursos sobre a inclusão escolar, que vemos circular na atualidade. Para isso, selecionamos algumas edições da revista Nova Escola, que apresentavam a inclusão escolar como tema central de suas matérias. Discursos marcados pelos termos “amor”, “doação”, “carinho”, “humanização” são examinados a partir de uma matriz moderna que investe na moralização dos afetos. Devemos estar abertos ao Outro para sermos tocados, desde que o que nos toca conspire a favor do bem e da ordem. Além disso, problematizamos a ênfase que tais discursos apresentam nos processos de socialização e de convivência. Eles marcam uma espécie de banalização da aprendizagem, uma vez que reiteram o convívio com o outro, o respeito às regras e o saber comportar-se como aprendizagens fundamentais nos processos de inclusão. Colocando esses discursos sob exame, o texto pretende provocar o pensamento e suspender as verdades consagradas acerca da inclusão escolar proferida pela modernidade.
Movimentos negros e direitos humanos
Authors: Baptista da Silva Paulo Vinicius , Espejo Trigo Rosa Amália , Marçal José Antonio
Published: July 2014

Este artigo é orientado pela interpretação do racismo numa dupla compreensão, de aspectos peculiares do contexto brasileiro e condicionantes do processo secular e supranacional de racialização da população negra. A análise busca destacar a participação e as contribuições dos movimentos sociais negros na formulação de Direitos e Políticas Públicas voltadas para a superação das desigualdades e discriminação racial. Com base em proposições realizadas pelo pesquisador Miguel Arroyo, focalizam-se as lutas e demandas dos movimentos sociais como fontes geradoras de propostas de direito. A primeira parte discute passagens específicas de movimentos sociais negros desenvolvidos ao longo do século XX. Na sequência, a análise se centra em momento entre 1995 e 2005, o qual revela articulações nacionais dos movimentos sociais: a Marcha Zumbi dos Palmares de 1995, o processo de pré-conferências até a III Conferência Mundial contra o racismo de 2001 e a Marcha Zumbi + 10 de 2005, examinando as propostas dos movimentos negros em documentos gerados para tais eventos. Discute ainda conexões dos movimentos negros com o governo federal, especialmente as proposições sistematizadas a partir das Conferências Nacionais de Promoção de Igualdade Racial (I CONAPIR/2005 e II CONAPIR/2009). Conclui com uma síntese das proposições e assinala a “acomodação de Atlanta” e a “iniciativa histórica”, expressas em distintas proposições de Direitos Humanos, como alternativas contraditórias para os movimentos sociais.
Trajetória social de alunos de um curso pré-vestibular popular
Authors: Masson Suficier Darbi , Muzzeti Luci Regina , Reina Fábio Tadeu
Published: July 2014

O objetivo da pesquisa que originou este artigo foi analisar a trajetória social de alunos e alunas de um curso pré-vestibular popular e verificar suas expectativas sobre o Ensino Superior. Foram utilizados na coleta dos dados questionário com questões abertas e fechadas e entrevista semiestruturada, elaborados com base nos modelos utilizados por Muzzeti (1997). Os dados foram analisados a partir da elaboração de quadros temáticos. Apoiada nas pesquisas realizadas por Pierre Bourdieu (1997, 2007), essa pesquisa concluiu que os estudantes entendem que a escolarização é, além de uma alternativa viável na busca pela ascensão social, a redentora dos males sociais. A escolha da profissão pela crença no talento natural ou por um dom divino gera expectativas que atestam o desconhecimento do sistema de ensino pelos estudantes e por seus pais, o que é reforçado pela crença na igualdade de oportunidades.
Interactions with RNA direct the Polycomb group protein SCML2 to chromatin where it represses target genes
Authors: Bonasio Roberto , Lecona Emilio , Narendra Varun , Voigt Philipp , Parisi Fabio , Kluger Yuval , Reinberg Danny
Published: July 2014

Polycomb repressive complex-1 (PRC1) is essential for the epigenetic regulation of gene expression. SCML2 is a mammalian homolog of Drosophila SCM, a Polycomb-group protein that associates with PRC1. In this study, we show that SCML2A, an SCML2 isoform tightly associated to chromatin, contributes to PRC1 localization and also directly enforces repression of certain Polycomb target genes. SCML2A binds to PRC1 via its SPM domain and interacts with ncRNAs through a novel RNA-binding region (RBR). Targeting of SCML2A to chromatin involves the coordinated action of the MBT domains, RNA binding, and interaction with PRC1 through the SPM domain. Deletion of the RBR reduces the occupancy of SCML2A at target genes and overexpression of a mutant SCML2A lacking the RBR causes defects in PRC1 recruitment. These observations point to a role for ncRNAs in regulating SCML2 function and suggest that SCML2 participates in the epigenetic control of transcription directly and in cooperation with PRC1.
The Adjudicating Citizen: On Equal Membership in Waltzer's Theory of Justice
Authors: VAN DER VEEN ROBERT J.
Published: July 2002

This article presents a reconstruction of Michael Walzer's pluralist theory in Spheres of Justice. It starts by noting that Walzer's main thesis (justice resides in autonomous spheres of social goods, according to principles reflecting each good's social meaning) is too restrictive to clarify his own concern with ‘complex equality’. After analysing the shortcomings of the thesis by reference to medical care and social security, this article proposes an account of ‘justice across spheres’: citizens adjudicate the boundaries of the distributive spheres so as to achieve complex equality, the state in which no one counts as another's social inferior. The citizens are held to be motivated by the desire to create and maintain what Walzer calls the ‘society of equals’. As a result, Walzer's theory is recast in a form that makes it easier to compare his distinctively pluralist approach with the abstract-egalitarian theories of Ronald Dworkin and John Rawls. The account of ‘justice across spheres’ is also used to explain Walzer's radical institutional recommendations for achieving complex equality in his own society, the United States.
Getting the Assumptions Right: A Reply to Laver and Shepsle
Authors: WARWICK PAUL V.
Published: July 2002

For some time now, formal modelling has been touted by its supporters as a panacea for political science – or at least as a major step forward in the discipline's development. Certainly, it embodies a number of praiseworthy elements. Its insistence on starting with a parsimonious and precisely formulated set of assumptions cannot help but constrain slippery thinking, for example, and its rigorous working out of implications, while often demonstrating the obvious, occasionally leads to unanticipated and intriguing results. Moreover, the combination of precision and rigour holds forth the promise of generating relatively clear-cut tests of rival explanations, a major boon – if it proves true – in a discipline more inclined to abandon theories than to disconfirm them.

How much better the analytical or formal orientation is, then, than the ‘funnel of causality’ approach of empiricists whose quest for the highest explained variance seldom produces more than a miscellaneous grab-bag of influences on the dependent phenomenon. Empirical work of that sort may have some limited utility in identifying possible causes, to be sure, but at some point the scholarly enterprise must move to the higher level of elaborating a clear logical structure among causal factors. Here, empirical success in accounting for observed phenomena cannot be the sole guide: the best theory is the one that provides the most accurate idea of what is actually going on in the real world, not the one with the best correlations.
Government Formation and Survival: A Rejoinder to Warwick's Reply
Authors: LAVER MICHAEL A. , SHEPSLE KENNETH A.
Published: July 2002

When an intellectual exchange gets ‘curiouser and curiouser’, it is probably time to bring it to a conclusion in the hope that scholars other than the principals involved will bring a fresh perspective to the issues in dispute. Certainly when the dispute begins to focus on fine-grained details that are of interest only to the disputants, it is time to move the discussion back to a more general plane. This we shall do, and do in the briefest of ways.
EQUITIES TO RESCIND AND INTERESTS UNDER RESULTING TRUSTS
Authors: Fox David
Published: July 2002

Twinsectra Ltd. v. Yardley [1999] Lloyd’s Rep. Bank. 438, a unanimous decision of the Court of Appeal, illustrates the various liabilities of a fiduciary who obtains money by a fraudulent misrepresentation. Apart from liability at law for deceit, he may be liable in equity as a resulting trustee or the claimant may rescind the transaction for fraud. This note asks how real the differences are between these two equitable means of reversing the unjust enrichment of the fiduciary.
The king is dead: long live the king
Authors: Davis Jennifer
Published: July 2002

CHARACTER merchandising is big business and any case concerning its legal protection is bound to arouse considerable interest. This is certainly true of the recent Court of Appeal decision in Elvis Presley Trade Marks [1999] R.P.C. 567, where the character concerned was “the King” himself. Earlier, in the “Ninja Turtles” passing-off case, Mirage Studios v. Counterfeat Clothing Co. Ltd. [1991] F.S.R. 145, the High Court had apparently endorsed the view that the public's awareness of merchandising practices means that it will assume that products carrying the likeness or name of a celebrity (real or fictional) will come from one “genuine” source. This decision, together with the provisions of the 1994 Trade Marks Act which swept away previous anti-trafficking provisions and liberalised the licensing regime, seemed, to many, to herald a new dawn for the protection of character merchandising, However, the Elvis Presley decision suggests that character merchandising in the UK will remain relatively unprotected compared to other jurisdictions.