bluuebunny/crossref_metadata_2025 huggingface dataset:
Anti-Ischemic Effects of PIK3IP1 Are Mediated through Its Interactions with the ETA-PI3Kγ-AKT Axis
Authors: Park Jei Hyoung , Nho Kyoung Jin , Lee Ji Young , Yoo Yung Joon , Park Woo Jin , Cho Chunghee , Kim Do Han
Published: July 2022

Oxidative stress, caused by the accumulation of reactive oxygen species (ROS) during acute myocardial infarction (AMI), is one of the main factors leading to myocardial cell damage and programmed cell death. Phosphatidylinositol-3-kinase-AKT (PI3K-AKT) signaling is essential for regulating cell proliferation, differentiation, and apoptosis. Phosphoinositide-3-kinase (PI3K)-interacting protein 1 (PIK3IP1) is an intrinsic inhibitor of PI3K in various tissues, but its functional role during AMI remains unknown. In this study, the anti-ischemic role of PIK3IP1 in an in vitro AMI setting was evaluated using H9c2 cells. The MTT assay demonstrated that cell viability decreased significantly via treatment with H2O2 (200–500 μM). The TUNEL assay results revealed substantial cellular apoptosis following treatment with 200 μM H2O2. Under the same conditions, the expression levels of hypoxia-inducible factor (HIF-1α), endothelin-1 (ET-1), bcl-2-like protein 4 (BAX), and cleaved caspase-3 were elevated, whereas those of PIK3IP1, LC3II, p53, and Bcl-2 decreased significantly. PIK3IP1 overexpression inhibited H2O2-induced and PI3K-mediated apoptosis; however, PIK3IP1 knockdown reversed this effect, suggesting that PIK3IP1 functions as an anti-apoptotic molecule. To identify both the upstream and downstream molecules associated with PIK3IP1, ET-1 receptor type-specific antagonists (BQ-123 and BQ-788) and PI3K subtype-specific antagonists (LY294002 and IPI-549) were used to determine the participating isoforms. Co-immunoprecipitation was performed to identify the binding partners of PIK3IP1. Our results demonstrated that ROS-induced cardiac cell death may occur through the ETA-PI3Kγ-AKT axis, and that PIK3IP1 inhibits binding with both ETA and PI3Kγ. Taken together, these findings reveal that PIK3IP1 plays an anti-ischemic role by reducing the likelihood of programmed cell death via interaction with the ETA-PI3Kr-AKT axis.
The Diagnostic Value of Circulating Cell-Free HPV DNA in Plasma from Cervical Cancer Patients
Authors: Bønløkke Sara , Stougaard Magnus , Sorensen Boe Sandahl , Booth Berit Bargum , Høgdall Estrid , Nyvang Gitte-Bettina , Lindegaard Jacob Christian , Blaakær Jan , Bertelsen Jesper , Fuglsang Katrine , Strube Mikael Lenz , Lenz Suzan , Steiniche Torben
Published: July 2022

Circulating cell-free HPV DNA (ccfHPV DNA) may serve as a marker for cervical cancer. In this study, we used digital droplet PCR (ddPCR) to detect and quantify ccfHPV DNA in plasma from patients with HPV16- or HPV18-associated cervical cancer. Blood samples from 60 patients diagnosed with cervical cancer (FIGO IA1-IVA) at Aarhus or Odense University Hospital (June 2018 to March 2020) were collected prior to treatment, and patients were subdivided into an early stage (n = 30) and a late-stage subgroup (n = 30) according to disease stage. Furthermore, blood samples from eight women with HPV16- or 18-associated premalignant conditions (CIN3), and 15 healthy controls were collected. ddPCR was used to analyze plasma from all participants. ccfHPV DNA was detected in 19 late-stage patients (63.33%), 3 early stage patients (10.00%), and none of the CIN3 patients or controls. Quantitative evaluation showed significant correlations between ccfHPV DNA level and stage, tumor score, and tumor size. Thus, our results indicate that ccfHPV DNA may not be a useful marker for early detection of cervical cancer. However, for patients with advanced stage cervical cancer, ccfHPV DNA level represents a promising tool to establish tumor burden, making it useful for establishing treatment response and monitoring the disease.
A Review on Potential Electrochemical Point-of-Care Tests Targeting Pandemic Infectious Disease Detection: COVID-19 as a Reference
Authors: Biswas Gokul Chandra , Choudhury Swapnila , Rabbani Mohammad Mahbub , Das Jagotamoy
Published: July 2022

Fast and accurate point-of-care testing (POCT) of infectious diseases is crucial for diminishing the pandemic miseries. To fight the pandemic coronavirus disease 2019 (COVID-19), numerous interesting electrochemical point-of-care (POC) tests have been evolved to rapidly identify the causal organism SARS-CoV-2 virus, its nucleic acid and antigens, and antibodies of the patients. Many of those electrochemical biosensors are impressive in terms of miniaturization, mass production, ease of use, and speed of test, and they could be recommended for future applications in pandemic-like circumstances. On the other hand, self-diagnosis, sensitivity, specificity, surface chemistry, electrochemical components, device configuration, portability, small analyzers, and other features of the tests can yet be improved. Therefore, this report reviews the developmental trend of electrochemical POC tests (i.e., test platforms and features) reported for the rapid diagnosis of COVID-19 and correlates any significant advancements with relevant references. POCTs incorporating microfluidic/plastic chips, paper devices, nanomaterial-aided platforms, smartphone integration, self-diagnosis, and epidemiological reporting attributes are also surfed to help with future pandemic preparedness. This review especially screens the low-cost and easily affordable setups so that management of pandemic disease becomes faster and easier. Overall, the review is a wide-ranging package for finding appropriate strategies of electrochemical POCT targeting pandemic infectious disease detection.
Intake of Fruits, Vegetables, and Sugar-Sweetened Beverages among a Sample of Children in Rural Northern Ontario, Canada
Authors: Button Brenton L. G. , McEachern Louise W. , Martin Gina , Gilliland Jason A.
Published: July 2022

There is evidence to suggest that dietary intake of children differs by rural/urban place of residence: rural children may have a higher intake of foods high in fat and sugar than those living in urban environments. The aim of this study was to examine the intake of fruits and vegetables (FV) and the frequency of sugar-sweetened beverage (SSB) consumption, among a sample of rural children in Northern Ontario, Canada, in two different seasons. Sociodemographic factors and children’s FV and SSB intake were measured using two repeated cross-sectional surveys, and seasonal information was based on the month of data collection. Logistic regressions were used to examine the odds of children eating five or more FVs, and the odds of ‘frequently or always’ consuming SSBs. During the fall, children reported eating five or more FV more often, when compared to winter (53.9% vs. 48.3%). In the fall, 25.8% of children reported ‘frequently or always’ drinking SSB, compared with 16.9% in winter. Indigenous children were less likely to eat five or more FV (OR 0.34 (95% CI 0.12–0.95)) in the fall when compared to non-Indigenous children. Findings indicate that intake of FV among rural students in this region is low, and the frequency of SSB is high, when compared with national recommendations.
The Role of Thermogenic Fat Tissue in Energy Consumption
Authors: Horino Masato , Ikeda Kenji , Yamada Tetsuya
Published: July 2022

Mammalian adipose tissues are broadly divided into white adipose tissue (WAT) and thermogenic fat tissue (brown adipose tissue and beige adipose tissue). Uncoupling protein 1 (UCP1) is the central protein in thermogenesis, and cells that exhibit induced UCP1 expression and appear scattered throughout WAT are called beige adipocytes, and their induction in WAT is referred to as “beiging”. Beige adipocytes can differentiate from preadipocytes or convert from mature adipocytes. UCP1 was thought to contribute to non-shivering thermogenesis; however, recent studies demonstrated the presence of UCP1-independent thermogenic mechanisms. There is evidence that thermogenic fat tissue contributes to systemic energy expenditure even in human beings. This review discusses the roles that thermogenic fat tissue plays in energy consumption and offers insight into the possibility and challenges associated with its application in the treatment of obesity and type 2 diabetes.
Regional Patterns of Coastal Erosion and Sedimentation Derived from Spatial Autocorrelation Analysis: Pacific and Colombian Caribbean
Authors: Coca Oswaldo , Ricaurte-Villota Constanza
Published: July 2022

Coastal erosion is a common phenomenon along the world’s coasts. Studying it is complex because such studies must cover large portions of land, and it is necessary to understand the multiple processes that interact in each area, so it is important to recognize regional patterns that allow for defining representativeness in relation to the surrounding dynamics. Spatial statistics can be used in coastal geomorphology to identify and quantify trends in coastal morphodynamics. This study analyzes and interprets the spatio-temporal patterns present in the changes in a shoreline, that is, the processes of erosion and coastal sedimentation in the Pacific and the Colombian Caribbean. The results are derived from the detection of significant changes in the coastline via satellite images. For this study, the shoreline of Colombia was digitized for the years 1986 and 2016, thus obtaining changes in the shoreline at a medium temporal scale. The Global Moran’s Index, Local Moran’s Index and Getis–Ord Index were used to explain the spatial statistics. The Global I Moran values for the Pacific were I = 0.190, z = 31.063 and p = 0.01, and for the Caribbean I = 0.624, z = 74.545 and p = 0.01, which suggests good grouping in the Caribbean and very low grouping for the Pacific. The local indices (Moran’s and Getis–Ord) allowed us to visualize and spatialize the significant points of coastal erosion and sedimentation. According to the results, three conceptual models are herein proposed that relate the indices with the geomorphological characteristics: (a) the greater the geomorphological heterogeneity, the greater the grouping; (b) the greater the geomorphological homogeneity, the lower the degree of clustering; (c) the greater the geomorphological complexity, the lower the degree of clustering. Finally, it is confirmed that coastal erosion and sedimentation processes predominate along low coasts.
Growth Mechanisms of TaN Thin Films Produced by DC Magnetron Sputtering on 304 Steel Substrates and Their Influence on the Corrosion Resistance
Authors: Serna-Manrique Milton David , Escobar-Rincón Daniel , Ospina-Arroyave Santiago , Pineda-Hernández Daniel Alejandro , García-Gallego Yury Paola , Restrepo-Parra Elisabeth
Published: July 2022

In this work, thin films of TaN were synthesized on 304 steel substrates using the reactive DC sputtering technique from a tantalum target in a nitrogen/argon atmosphere. All synthesis parameters such as gas ratio, pressure, gas flow, and substrate distance, among others, were fixed except the applied power of the source for different deposited coatings. The effect of the target power on the formation of the resulting phases and the microstructural and morphological characteristics was studied using XRD and AFM techniques, respectively, in order to understand the growth mechanisms. Phase, line profile, texture, and residual stress analysis were carried out from the X-ray diffraction patterns obtained. Atomic force microscopy analysis allowed us to obtain values for surface grain size and roughness which were related to growth mechanisms in accordance with XRD results. Results obtained showed a strong correlation between the growth energy with the crystallinity of the samples and the formation of the possible phases since the increase in the growth power caused the samples to evolve from an amorphous structure to a cubic monocrystalline structure. For all produced samples, the δ-TaN phase was observed despite the low N2 content used in the process (since for low N2 content it was expected to be possible to obtain films with α-Ta or hexagonal ε-TaN crystalline structure). In order to determine the corrosion resistance of the coatings, electrochemical impedance spectroscopy and polarization resistance were employed in the Tafel region. The results obtained through this evaluation showed a direct relationship between the power used and the improvement of the properties against corrosion for specific grain size values.
Effect of Indoor Bioaerosols (Fungal) Exposure on the Health of Post-COVID-19 Patients and Possible Mitigation Strategies
Authors: Vishwakarma Yogesh Kumar , Shahi Amrita , Singh Ram Sharan
Published: July 2022

Bioaerosols are present everywhere around us, either on surfaces or in the air. Depending on their nature, these bioaerosols have positive or negative impacts on our bodies. Our immune system always creates a balance in our health system in response to these bioaerosols. If our body’s immune system is compromised for a while, it could have many severe health complications. A good example is in patients who recovered from COVID-19 during the COVID-19 pandemic. During treatment, many drugs like dexamethasone, tocilizumob, itolizumab, and steroids were extensively used that suppressed the immune system, resulting in many fungal infections. In this review, we summarise the various studies carried out throughout the globe regarding fungal infection, including Mucormycetes (black fungus), Candida spp., Aspergillus fumigatus, and pneumocystis jirovecii. The patient disease history and treatment details were also examined so as to develop the risk of mortality. Populations with other pre-existing diseases such as diabetes and asthma are more vulnerable to infection. These infections spread at a very high rate and have a high risk of mortality in patients who have recovered from COVID-19. Earnest attention is needed regarding the treatment procedure of COVID-19 patients and for the follow-up of recovered patients. Here, we suggest some treatment methods that will help prevent infection in patients who have recovered from COVID-19 or in immunosuppressed bodies.
Piezoresistive Memories Based on Two-Dimensional Nano-Scale Electromechanical Systems
Authors: López-Suárez Miquel , Cottone Francesco , Neri Igor
Published: July 2022

In this work we present piezoresistive memory-bits based on two-dimensional nano-scale electro-mechanical systems. We demonstrate it is possible to achieve different electrical responses by fine control of micro-structural asymmetries and that information can be encoded in the geometrical configuration of the device and read as in classical ReRAM memories by measuring the current flowing across it. Based on the potential energy landscape of the device, we estimate the energy cost to operate the proposed memories. The estimated energy requirements for a single bit compete with existing technologies.
Efficacy of Prednisolone/Zn Metal Complex and Artemisinin Either Alone or in Combination on Lung Functions after Excessive Exposure to Electronic Cigarettes Aerosol with Assessment of Antibacterial Activity
Authors: Hamza Reham Z. , Alaryani Fatima S. , Alotaibi Reem E. , Al-Harthi Maha A. , Alotaibi Ghadeer S. , Al-Subaie Nora A. , Al-Talhi Amjad A. , Al-Bogami Bander , Al-Baqami Najah M. , El-Megharbel Samy M. , Al-Thubaiti Eman H.
Published: July 2022

The use of transition metal complexes as therapeutic compounds has become more and more pronounced. These complexes offer a great diversity of uses in their medicinal applications. Electronic cigarettes (ECs) are an electronic nicotine delivery system that contain aerosol (ECR). The ligation behavior of prednisolone, which is a synthetic steroid that is used to treat allergic diseases and asthma arthritis, and its Zn (II) metal complex were studied and characterized based on elemental analysis, molar conductance, Fourier-transform infrared (FT-IR) spectra, electronic spectra, XRD, scanning electron microscopy (SEM), energy dispersive x-ray (EDX), and transmission electron microscopy (TEM). The FT-IR spectral data revealed that PRD acts as a mono-dentate ligand via oxygen atoms of the carbonyl group. Electronic and FT-IR data revealed that the PRD/Zn (II) metal complexes have square planner geometry. Artemisinin (ART) is the active main constituent of Artemisia annua extract, and it has been demonstrated to exert an excellent antimalarial effect. The experiment was performed on 40 male mice that were divided into the following 7 groups: Control, EC group, PRD/Zn, ART, EC plus PRD/Zn, EC plus ART, and PRD plus combination of PRD/Zn and ART. Serum CRP, IL-6, and antioxidants biomarkers were determined. Pulmonary tissue histology was evaluated. When in combination with Zn administration, PRD showed potent protective effects against pulmonary biochemical alterations induced by ECR and suppressed severe oxidative stress and pulmonary structure alterations. Additionally, PRD/Zn combined with ART prevented any stress on the pulmonary tissues via antioxidant regulation, reducing inflammatory markers CRP and Il-6 and improving antioxidant enzymatic levels more than either PRD or ART alone. Therefore, PRD/Zn combined with ART produced a synergistic effect against any sort of oxidative stress and also improved the histological structure of the lung tissues. These findings are of great importance for saving pulmonary function, especially during pandemic diseases, such as during the COVID-19 pandemic.
Changes in the Mandible Following Rapid Maxillary Expansion in Children with Class II Malocclusion: A Systematic Review
Authors: Kotarska Małgorzata , Kucukkeles Nazan , Lis Joanna , Kawala Beata , Rumin Kornelia , Sarul Michał
Published: July 2022

Objective: The aim of this systematic review was to determine whether rapid maxillary expansion (RME) allows favorable changes in the mandible during the treatment of class II malocclusion before the growth spurt. Methods: A search of Pubmed/Medline, the Science Direct, and the Google Scholar database was performed. The keywords used were: orthodontics, rapid maxillary expansion, class II, and growing patients. Relevant articles were assessed for quality according to Cochrane guidelines, and then changes in SNA, SNB, ANB, NL-NSL (or SN-SNP.SNA), and ML-NSL (or SN-Go-Gn) relationships were analyzed. Results: The selection process brought forth five articles, including 162 patients (91 females, 71 males) for detailed analysis. The quality of the evidence (GRADE) for comparisons and outcomes was assessed as moderate for SNB and ANB and as low or very low for other variables. Conclusions: The results of this systematic review showed that there is a small body of moderate-quality evidence for statistically and clinically favorable changes in SNB and ANB angles and a small body of low-quality evidence for changes in vertical parameters after RME.
Editorial: Special Issue “Biomarkers in Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS)”
Authors: Neuhaus Jochen , Gonsior Andreas , Berndt-Paetz Mandy
Published: July 2022

Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS) is a disabling chronic disease of still unknown origin and complex pathophysiology [...]
Quantum Chaos, Random Matrices, and Irreversibility in Interacting Many-Body Quantum Systems
Authors: Weidenmüller Hans A.
Published: July 2022

The Pauli master equation describes the statistical equilibration of a closed quantum system. Simplifying and generalizing an approach developed in two previous papers, we present a derivation of that equation using concepts developed in quantum chaos and random-matrix theory. We assume that the system consists of subsystems with strong internal mixing. We can then model the system as an ensemble of random matrices. Equilibration results from averaging over the ensemble. The direction of the arrow of time is determined by an (ever-so-small) coupling to the outside world. The master equation holds for sufficiently large times if the average level densities in all subsystems are sufficiently smooth. These conditions are quantified in the text, and leading-order correction terms are given.
Philosophical Perspectives and Practical Considerations for the Inclusion of Students with Developmental Disabilities
Authors: Anderson Eric J. , Brock Matthew E. , Shawbitz Kara N.
Published: July 2022

Federal law in the United States requires that students with disabilities receive their education alongside their peers without disabilities to the maximum extent appropriate given their individual circumstances. As a result, students with less support needs have enjoyed increasing amounts of time in the regular education classroom, while their peers with developmental disabilities are still largely served in separate educational settings. When these students are not included in the regular education classroom, they are not able to access the academic, social, and communication benefits of inclusion. The inclusion of students with developmental disabilities has long been a point of contention and disagreement among special education teachers, administrators, and scholars. It is the goal of this paper to carefully consider the perspectives and practical considerations that affect the placement of students with developmental disabilities and understand why these students spend less time in the regular education classroom than their peers with other disabilities. In addition, we weigh the relative advantages of inclusive and separate placements. After reviewing these issues, we believe that it is possible to simultaneously value a spectrum of placement options and advocate for increased inclusion in the regular education classroom. We discuss evidence-based practices to support inclusive placements and areas of future research to support inclusion of students with developmental disabilities in the regular education classroom.
Medical Communication Perceived Self-Efficacy (ME-CO) Scale: Construction and Validation of a New Measuring Instrument from a Socio-Cognitive Perspective
Authors: Capone Vincenza
Published: July 2022

The study presents the validation of a scale measuring physicians’ efficacy beliefs about their ability to manage issues related to communication with patients. Specifically, the tool focused on three fundamental phases of the clinical interview: collecting information, returning information to patients, and creating and maintaining a relationship with them. The research included two studies. Study 1 generated an item pool based on the literature review and developed a self-report questionnaire administered to a pilot sample of 150 physicians (MAge = 49.36; SD = 1.98). The responses were subjected to exploratory analysis. In total, 636 physicians (MAge = 47.99; SD = 8.68) took part in Study 2. Exploratory and confirmatory analyses yielded a final version of the tool consisting of an eight-factor structure with 31 items. Findings provided evidence of the robust psychometric properties of the scale and its usefulness in assessing physicians’ self-efficacy and defining effective interventions aimed at strengthening the doctors’ communication skills. The scale detected different aspects of physicians’ communication self-efficacy (asking questions, active listening, giving information, communicating an inauspicious diagnosis, non-verbal communication, recognition of patient’s clues and suggestions, information checking, and empathy).
Running on Empty: Self-Reported Sleep/Wake Behaviour during Ultra-Marathon Events Exceeding 100 Miles
Authors: Miller Dean J. , Bianchi Darren , Lastella Michele
Published: July 2022

The aim of this study was to examine sleep/wake behaviour and sleep strategies before, during and after ultra-marathon running events exceeding 100 miles (161 km). A total of 119 athletes completed a web-based questionnaire regarding their habitual sleep/wake behaviour before, during, and after ultra-marathon participation. Event-specific data were grouped by race distance categories; 100–149 miles (161–240 km), 150–199 miles (241–321 km), and ≥200 miles (322 km). Athletes commonly reported not sleeping throughout the duration of their races (74%). However, for events that were ≥200 miles, athletes reported more sleep opportunities, longer sleep duration, and more total sleep when compared to events that were 100–149 miles in distance (p ≤ 0.001). This suggests that for races of shorter distances, the benefit of continuous racing outweighs the negative impact of continuous wakefulness/sleep deprivation. However, for longer races (≥200 miles), there is an apparent tradeoff between sleep deprivation and race strategy, whereby athletes cannot sustain a desired level of performance without obtaining sleep. This is consistent with established sleep/wake behaviour models suggesting that sleep need increases as wakefulness increases, or in this case, as race duration increases. For athletes participating in ultra-marathons, sleep management education and/or consultation with a sleep scientist prior to racing may be beneficial. Future research should examine the optimal strategies concerning the frequency and duration of sleep during ultra-marathons and the subsequent impact on performance.
A Compact Broadband Analog Complex Correlator with High Correlation Efficiency for Passive Millimeter-Wave Imaging System
Authors: He Wangdong , Hu Anyong , Chen Xi , Gong Jianhao , Miao Jungang
Published: July 2022

In this paper, the design, fabrication, and measurement of a compact broadband (4–8 GHz) analog complex correlator for a passive millimeter-wave imaging system are presented. To achieve high sensitivity and high integration of the imaging system, the wideband and miniaturization of the correlator are required. The correlator achieves wide bandwidth by using the add-and-square method, which is composed of a six-port circuit and a detection circuit. In order to realize the miniaturization of the correlator, the six-port circuit is realized on the chip base on the 0.15-μm gallium arsenide (GaAs) process. The influence of mismatch of the detection circuit that employs zero-bias Schottky diodes on the correlator is also analyzed to guide the design of the correlator. The measurement results of the designed chips and detector are consistent with the simulation result. Finally, a Sweep-frequency test is applied to the designed correlator, and the measurement results show that, within the frequency range of 4–8 GHz, the correlation amplitude fluctuation is less than 1.9 dB and the correlation efficiency is larger than 99%, which reveal that the correlator is suited for interferometric passive millimeter-wave imaging applications.
Statistical Analysis of the Variability of Energy Efficiency Indicators for a Multi-Family Residential Building
Authors: Życzyńska Anna , Suchorab Zbigniew , Majerek Dariusz , Motuzienė Violeta
Published: July 2022

During the building design phase, a lot of attention is paid to the thermal properties of the external envelopes. New regulations are introduced to improve energy efficiency of a building and impose a reduction of the overall heat transfer coefficient; meanwhile, this efficiency is more influenced by the efficiency of the heating system and the type of fuels used. This article presents a complex analysis including the impact of: heat transfer coefficient of the envelope, efficiency of building service systems, the type of energy source, and the fuel. The analysis was based on the results of simulation tests obtained for an exemplary multi-family residential building located in Poland that is not equipped with a cooling system. The conducted calculations gave quantitative evaluation of the influence of particular parameters on building energy performance and showed that the decrease of heat transfer coefficient of building boundaries, in accordance to the Polish regulation for 2017 and 2021, gave only 11% of reduction on usable energy demand index. On the other hand, it was found that modification of the heating system and heat source can significantly influence the values of the final and primary energy consumption at the level of 70%. The application of heat pumps has a greater influence on the final and primary energy consumption for heating indices than other parameters, such as the building’s envelopes.
Multiphysics Design of an Automotive Regenerative Eddy Current Damper
Authors: Jamolov Umid , Peccini Francesco , Maizza Giovanni
Published: July 2022

This research presents a finite element multi-physics design methodology that can be used to develop and optimise the inherent functions and geometry of an innovative regenerative eddy current (REC) damper for the suspension of B class vehicles. This methodology was inspired by a previous work which has been applied successfully for the development of an eddy current (EC) damper used for the same type of applications. It is based on a multifield finite element coupled model that can be used to fulfil the electromagnetic, thermal, and fluid dynamic field properties and boundary conditions of a REC damper, as well as its non-linear material properties and boundary conditions, while also analysing its damping performance. The proposed REC damper features a variable fail-safe damping force, while electric power is advantageously regenerated at high suspension frequencies. Its damping performance has been benchmarked against that of a regular hydraulic shock absorber (selected as a reference) by analysing the dynamic behaviour of both systems using a quarter car suspension model. The results are expressed in terms of damping force, harvested power, thermal field, comfort and handling, with reference to ISO-class roads. The optimisation analysis of the REC damper has suggested useful guidelines for the harmonisation of damping and regenerative power performances during service operation at different piston speeds.
Development of a Fault-Diagnosis System through the Power Conversion Module of an Electric Vehicle Fast Charger
Authors: Park Sang-Jun , Kim Woo-Joong , Kang Byeong-Su , Jang Sung-Hyun , Choi Yeong-Jun , Hong Young-Sun
Published: July 2022

The supply of electric vehicles (EVs), charging infrastructure, and the demand for chargers are rapidly increasing owing to global low-carbon and eco-friendly policies. As the maintenance of charging infrastructure varies depending on the manufacturer, fault detection and maintenance cannot be conducted promptly. Consequently, user inconvenience increases and becomes an obstacle to EV distribution. Recognizing charger failure after occurrence is a management method that is not economically effective in terms of follow-up. In this study, a data collection system was developed to diagnose EV fast-charger failure remotely in advance. The power module failure-prediction and management system consists of an AC sensor, DC sensor, temperature and humidity sensor, communication board, and data processing device. Furthermore, it was installed inside the fast charger. Four AC inputs, four DC outputs, and temperature and humidity data were collected for 12 months. Using the collected data, the power conversion efficiency was calculated and the power module status was diagnosed. In addition, a multilayer perceptron neural network was used as an algorithm for training the classification model. Charging patterns according to normal and failure were trained and verified. Based on results, the pre-failure diagnosis system demonstrated an accuracy of 97.2%.
Methods of Assessing the Effectiveness of Filter Elements in Power Electronics
Authors: Borecki Michał , Sroka Jan
Published: July 2022

Newly constructed devices must meet a number of requirements in terms of the level of generated disturbances. To achieve an acceptable level in such devices, filters are installed—one of the cheapest ways to reduce interference in devices. One of the key elements of the filter that is responsible for the effectiveness of noise reduction are ferrites. Unfortunately, for various devices, an individual approach should be used in the selection of filters and, accordingly, ferrites. Due to the fact that ferrites from different manufacturers do not have standardized characteristics and information on their effectiveness, the selection of the right ferrite is a very time-consuming process. Therefore, this article will present the possibilities of quickly determining selected ferrite parameters in order to ensure the necessary level of noise reduction. For this purpose, assumptions from the CISPR 17 standard will be used. For selected types of ferrites, a large number of measurements were carried out in order to determine the optimal computational algorithm for adjusting ferrite characteristics to the designed conditions. The performance of these tests will be the basis for conducting tests on a larger number of ferrites, as well as for the development of possible standardization procedures.
Optimization of Laminar Boundary Layers in Flow over a Flat Plate Using Recent Metaheuristic Algorithms
Authors: Gunal Ozen , Akpinar Mustafa , Ovaz Akpinar Kevser
Published: July 2022

Heat transfer is one of the most fundamental engineering subjects and is found in every moment of life. Heat transfer problems, such as heating and cooling, where the transfer of heat between regions is calculated, are problems that can give exact solutions with parametric equations, many of which were obtained by solving differential equations in the past. Today, the fact that heat transfer problems have a more complex structure has led to the emergence of multivariate models, and problems that are very difficult to solve with differential equations have emerged. Optimization techniques, which are also the subject of computer science, are frequently used to solve complex problems. In this study, laminar thermal boundary layers in flow over a flat plate, a sub-problem of heat transfer, is solved with recent metaheuristic algorithms. Teaching learning-based optimization (TLBO), sine cosine optimization (SCO), gray wolf optimization (GWO), whale optimization (WO), salp swarm optimization (SSO), and Harris hawk optimization (HHO) algorithms are used in the study. In the optimization problem, the laminar boundary layer thickness, heat flow, and distance from the leading edge are determined. These three models’ minimum, maximum, and target values are found under the specified design variables and constraints. In the study, 540 optimization models are run, and it is seen that HHO is the most suitable optimization technique for heat transfer problems. Additionally, SSO and WO algorithms gave results close to HHO. Other algorithms also set model targets with an average of less than 0.07% and acceptable error rates. In addition, the average problem solution time of all optimization algorithms and all models was 0.9 s. To conclude, the recent metaheuristic algorithms are found to be powerful and fast in solving heat transfer problems.
Toxicity of Formulated Systemic Insecticides Used in Apple Orchard Pest Management Programs to the Honey Bee (Apis mellifera (L.))
Authors: Heller Sarah , Fine Julia , Phan Ngoc T. , Rajotte Edwin G. , Biddinger David J. , Joshi Neelendra K.
Published: July 2022

Honey bees (Apis mellifera) are one of the most important pollinating species of flowering plants. Recently, populations of honey bees have been declining due to a combination of factors, including the widespread use of agricultural pesticides. Laboratory studies were conducted to determine the acute oral toxicity of different formulated pesticides to honey bee adults. In particular, we assessed the acute oral toxicity of two neonicotinoids (acetamiprid, Assail 30SG and thiamethoxam, Actara 25WDG) and two other systemic insecticide products (sulfoxaflor, Closer 2SC and flupyradifurone, Sivanto 200SL), all of which are generally used in pest management programs in commercial apple orchards in the Eastern United States. Honey bees were fed a range of doses of each pesticide in order to create a response curve, and LC50, LC90, and LD50 values were determined. The pesticide formulation containing flupyradifurone as the active ingredient was found to be the least toxic to honey bees followed by the formulations containing sulfoxaflor and acetamiprid. The toxicity values obtained in this study differ from other studies testing only technical active ingredient compounds, suggesting the need to evaluate formulated products while conducting ecotoxicological risk assessment.
CH4 and CO2 Emissions from the Decomposition of Microplastics in the Bottom Sediment—Preliminary Studies
Authors: Kida Małgorzata , Ziembowicz Sabina , Koszelnik Piotr
Published: July 2022

In recent years, a significant new threat to the environment has emerged, namely contamination with microplastics and their degradation products. The decomposition products of microplastics include, among others, greenhouse gases that are responsible for climate change. The article analyzes the emission of carbon dioxide and methane during the decomposition of various types of plastics in the form of microplastics in the bottom sediments in the presence of water. The research covers plastic materials made of polyvinyl chloride with a high and low content of plasticizers, polypropylene, and rubber. All analyzed microplastics generated the tested greenhouse gases. However, the quantity of gases generated depended on the type of polymer used. The highest concentration of methane, at 25,253 ppm after 180 days of incubation, was characterized by high plasticizer polyvinyl chloride, i.e., di (2-ethylhexyl) phthalate. In the case of carbon dioxide emissions, the values were comparable. The maximum value was obtained at 65,662 ppm for polypropylene microplastics. The influence of particle size on the amount of the emissions of these gases was also investigated. During the decomposition of microplastics in the bottom sediments in the presence of water, it was observed that the smaller the microplastic particles are, the greater the production of methane and carbon dioxide.
Intensification of Acidogenic Fermentation for the Production of Biohydrogen and Volatile Fatty Acids—A Perspective
Authors: Nagarajan Sanjay , Jones Rhys Jon , Oram Lucy , Massanet-Nicolau Jaime , Guwy Alan
Published: July 2022

Utilising ‘wastes’ as ‘resources’ is key to a circular economy. While there are multiple routes to waste valorisation, anaerobic digestion (AD)—a biochemical means to breakdown organic wastes in the absence of oxygen—is favoured due to its capacity to handle a variety of feedstocks. Traditional AD focuses on the production of biogas and fertiliser as products; however, such low-value products combined with longer residence times and slow kinetics have paved the way to explore alternative product platforms. The intermediate steps in conventional AD—acidogenesis and acetogenesis—have the capability to produce biohydrogen and volatile fatty acids (VFA) which are gaining increased attention due to the higher energy density (than biogas) and higher market value, respectively. This review hence focusses specifically on the production of biohydrogen and VFAs from organic wastes. With the revived interest in these products, a critical analysis of recent literature is needed to establish the current status. Therefore, intensification strategies in this area involving three main streams: substrate pre-treatment, digestion parameters and product recovery are discussed in detail based on literature reported in the last decade. The techno-economic aspects and future pointers are clearly highlighted to drive research forward in relevant areas.
Meteorological Conditions Associated with Lightning Ignited Fires and Long-Continuing-Current Lightning in Arizona, New Mexico and Florida
Authors: Pérez-Invernón Francisco J. , Huntrieser Heidi , Moris Jose V.
Published: July 2022

Lightning is the main precursor of wildfires in Arizona, New Mexico, and Florida during the fire season. Forecasting the occurrence of Lightning-Ignited Wildfires (LIW) is an essential tool to reduce their impacts on the environment and society. Long-Continuing-Current (LCC) lightning is proposed to be the main precursor of LIW. The long-lasting continuing current phase of LCC lightning is that which is more likely to ignite vegetation. We investigated the meteorological conditions and vegetation type associated with LIW and LCC lightning flashes in Arizona, New Mexico, and Florida. We analyzed LIW between 2009 and 2013 and LCC lightning between 1998 and 2014 and combined lightning and meteorological data from a reanalysis data set. According to our results, LIW tend to occur during dry thunderstorms with a high surface temperature and a high temperature gradient between the 700 hPa and the 450 hPa vertical levels for high-based clouds. In turn, we obtained a high lightning-ignition efficiency in coniferous forests, such as the ponderosa pine in Arizona and New Mexico and the slash pine in Florida. We found that the meteorological conditions that favor fire ignition and spread are more significant in Florida than in Arizona and New Mexico, while the meteorological conditions that favor the occurrence of LIW in Arizona and New Mexico are closely related with the meteorological conditions that favor high lightning activity. In turn, our results indicate high atmospheric instability during the occurrence of LIW. Our findings suggest that LCC (>18 ms) lightning tends to occur in thunderstorms with high relative humidity and ice content in the clouds, and with low temperature in the entire troposphere. Additionally, a weak updraft in the lower troposphere and a strong one in the upper troposphere favor the occurrence of LCC (>18 ms) lightning. We found that the meteorological conditions that favor the occurrence of LCC (>18 ms) lightning are not necessarily the preferential meteorological conditions for LIW.
Numerical Investigation of the Hydrodynamic Behavior of Trash-Blocking Nets for Water Intake Engineering of Nuclear Power Plant
Authors: Jiang Zhenqiang , Wang Tongyan , Wang Bin , Xu Tiaojian , Ma Changlei , Shen Kanmin
Published: July 2022

In order to ensure the safety of the cooling water source of coastal nuclear power plants (NPP), trash-blocking nets (TBNs) are usually installed at the entrance of the penstock to prevent marine sewage and organisms flowing into the front pool of the pump house of the nuclear power plant. The safety evaluation of these trash-blocking nets is of paramount importance for the stable operation of a nuclear power plant. However, there is no reliable analysis method for improving the design of trash-blocking nets and mooring systems. In this study, a numerical model of in-current trash-blocking nets based on the lumped mass method was developed to calculate the tension force on the trash-blocking nets and mooring system. A comparison with the experimental data indicates that the present numerical model is appropriate for calculating the in-current hydrodynamic loads on the trash-blocking nets. In addition, the effects of the width of trash-blocking nets, hanging ratio, water depth, and net solidity are discussed in detail, and the damage process of trash-blocking nets was also investigated. The results indicate that the maximum tension force on the trash-blocking net linearly increases with the increasing width of trash-blocking nets, and it is greatly decreased with the increase in the horizontal hanging ratio of trash-blocking nets. It can be increased by 200% when the net solidity is increased from 0.16 to 0.6. Two damage modes for mooring lines can be observed, which are determined by the strength of mooring lines.
Arbitrary Hybrid Turbulence Modeling Approach for High-Fidelity NREL Phase VI Wind Turbine CFD Simulation
Authors: Kamalov Bagdaulet , Batay Sagidolla , Zhangaskhanov Dinmukhamed , Zhao Yong , Ng Eddie Yin Kwee
Published: July 2022

Today, growth in renewable energy is increasing, and wind energy is one of the key renewable energy sources which is helping to reduce carbon emissions and build a more sustainable world. Developed countries and worldwide organizations are investing in technology and industrial application development. However, extensive experiments using wind turbines are expensive, and numerical simulations are a cheaper alternative for advanced analysis of wind turbines. The aerodynamic properties of wind turbines can be analyzed and optimized using CFD tools. Currently, there is a general lack of available high-fidelity analysis for the wind turbine design community. This study aims to fill this urgent gap. In this paper, an arbitrary hybrid turbulence model (AHTM) was implemented in the open-source code OpenFOAM and compared with the traditional URANS model using the NREL Phase VI wind turbine as a benchmark case. It was found that the AHTM model gives more accurate results than the traditional URANS model. Furthermore, the results of the VLES and URANS models can be improved by improving the mesh quality for usage of higher-order schemes and taking into consideration aeroelastic properties of the wind turbine, which will pave the way for high-fidelity concurrent multidisciplinary design optimization of wind turbines.
Effects of Dietary Energy Density in a Fermented Total Mixed Ration Formulated with Different Ratios of Rice Straw and Cassava Pulp on 2- or 14-Day-Aged Meat Quality, Collagen, Fatty Acids, and Ribonucleotides of Native Thai Cattle Longissimus Muscle
Authors: Chaosap Chanporn , Lukkananukool Achara , Polyorach Sineenart , Sommart Kritapon , Sivapirunthep Panneepa , Limsupavanich Rutcharin
Published: July 2022

This study investigated the effects of dietary energy density in rice straw and cassava pulp fermented total mixed ration on pH, cooking loss, Warner–Bratzler shear force (WBSF), and collagen content of 2- or 14-d-aged native Thai cattle (NTC) Longissimus thoracic (LT) muscles and fatty acids and ribonucleotides of 2-d-aged LT. Eighteen yearling NTC (Bos indicus) were randomly divided into three dietary treatments (T1 = 8.9, T2 = 9.7, and T3 = 10.5 MJ ME/kg), with six bulls per treatment. The results showed that T1 had the highest WBSF (p < 0.05). However, T2 had similar WBSF to T3 (p > 0.05). With aging, cooking loss increased (p < 0.01), while WBSF decreased (p < 0.01). Insoluble and total collagen decreased with aging (p < 0.05). Dietary energy density had no effect (p > 0.05) on collagen content, ribonucleotides and most fatty acids. However, T1 had more (p < 0.05) decanoic (C10:0), vaccenic (C18:1n9t), trans-linolelaidic (C18:2n6t), eicosatrienoic (C20:3n6), and docosadienoic (C22:2) acids than T2 and T3. In terms of lowest feed cost with comparable tenderness to T2 and highest energy density, T3 may be well suited for feeding NTC. Aging for 14 days improves LT tenderness, but its cooking loss may affect yield and juiciness.
Thermal Stability of Fructooligosaccharides Extracted from Defatted Rice Bran: A Kinetic Study Using Liquid Chromatography-Tandem Mass Spectrometry
Authors: Le Hoang Phuong , Hong Diep Thanh Nghi , Nguyen Thi Thao Loan , Le Thi My Hanh , Koseki Shige , Ho Thanh Binh , Ly-Nguyen Binh
Published: July 2022

Thermal degradation kinetics of fructooligosaccharides (FOS) in defatted rice bran were studied at temperatures of 90, 100, and 110 °C. FOS extracted from rice bran and dissolved in buffers at pH values of 5.0, 6.0, and 7.0 were prepared for the thermal treatments. The residual FOS (including 1-kestose (GF2), nystose (GF3), and 1F-fructofuranosylnystose (GF4)) contents were determined using the ultra-performance liquid chromatography-electrospray ionization-tandem mass spectrometry (UPLC-ESI-MS/MS) method. The results showed that the thermal degradation kinetics of GF2, GF3, and GF4 followed a first-order kinetic model. Thermal degradation rate constants (k values) of GF2, GF3, and GF4 at different temperature and pH values were estimated using the first-order kinetic equation and SAS 9.1. As a result, these k values decreased gradually as the pH of the sample increased from 5.0 to 7.0. The Arrhenius model was applied to describe the heat dependence of the k-values. The activation energy (Ea) was calculated for each case of GF2, GF3, and GF4 degradation at pH values of 5.0, 6.0, and 7.0. The result showed that rice bran FOS is very thermostable at neutral pH while more labile at acidic pH.