bluuebunny/crossref_metadata_2025 huggingface dataset:
Дальневосточные голотурии и асцидии как ценное пищевое сырьё
Authors: Савватеева Л. Ю. , Маслова М. Г. , Володарский В. Л. , Гурина Л. И.
Published: July 2022

Переработанное издание представляет собой обобщённый теоретический и практический материал о кукумарии, трепанге и халоцинтии пурпурной, обитающих в дальневосточных морях. Приводятся биологические особенности водных биоресурсов, показывается их ценность, даётся технология рациональных процессов тепловой обработки сырья, предлагаются рецепты приготовления продуктов питания, изложены результаты экспериментального и клинического применения продуктов из гидробионтов в оздоровительной практике. Для специалистов рыбной промышленности, технологов общественного питания, товароведов продовольственных товаров, специалистов в сфере животноводства, медицинских работников, студентов биологических факультетов и всех тех, кто интересуется вопросами использования водных биоресурсов в народном хозяйстве и медицине.
A formação continuada enquanto política pública: ações e programas para atender às necessidades dos professores
Authors: Nogueira Adrinelly , Borges Maria Célia
Published: July 2022

Este estudo teve como objetivo entender a formação continuada enquanto política pública em um município do Triângulo Mineiro. Baseou-se em uma pesquisa qualitativa, orientada epistemologicamente pela abordagem dialética. Quanto aos procedimentos de coleta de dados, foram utilizados os seguintes: pesquisa bibliográfica, documental e de campo. Na pesquisa empírica utilizou-se questionários online como instrumentos para a coleta de dados. Conclui-se que para os professores e gestores políticas públicas são ações e programas desenvolvidos para atender às necessidades e interesses do povo. Constatamos que existe um projeto de formação continuada para os professores no município, mas são necessárias novas perspectivas em relação às políticas públicas e práticas educativas da rede.
Shared decision-making in the management of hereditary angioedema: An analysis of patient and physician perspectives
Authors: Riedl Marc A. , Neville Deborah , Cloud Blaine , Desai Bhavisha , Bernstein Jonathan A.
Published: July 2022

Background: Hereditary angioedema (HAE) is a rare genetic disorder characterized by recurrent, localized episodes of edema. Current treatment guidelines highlight the importance of shared decision-making (SDM) during implementation of HAE management plans. Objective:
To determine what constitutes a successful SDM approach in HAE management. Method: Qualitative telephone interviews, which lasted ∼1 hour, were conducted with four HAE physicians and four patients from the APeX-S trial. The physicians were asked to describe the
structure and/or content of typical HAE prophylaxis consultations and factors to consider when selecting medications for long-term treatment. Insights from these interviews were used to develop an SDM process diagram. The patients were interviewed to assess how closely the diagram fit their
perspectives on the HAE consultation and their involvement in decisions that concerned their care. Interview transcripts were assessed by the interviewer to determine the degree of SDM involvement in each consultation by using qualitative criteria from the literature. Results:
Two physicians followed a high-SDM format, and one physician used a “blended” approach. The fourth physician followed a standard (low SDM) format. A successful SDM approach was found to require pre-visit planning, a commitment on behalf of the physician to use SDM methods to
learn more about the patient, and empowerment of the patient to reflect on and vocalize his or her preferences and/or needs. Patients engaged in SDM were more likely to proactively request a treatment switch. Conclusion: The adoption of validated HAE-specific treatment
decision aids, as well as measures to change the mindsets of patients and physicians, may facilitate successful implementation of SDM in HAE.Clinical Trial Registration: The APeX-S trial was registered with clinicaltrials.gov (NCT03472040).
Barreras invisibles: Validación de un instrumento para valorar la actitud hacia las personas con discapacidad intelectual
Authors: García-Sanz Mari Paz , Belmonte María Luisa , Galián Begoña
Published: July 2022

Introducción.  El fomento de la inclusión educativa, social y laboral está generando que las personas con discapacidad intelectual sean aceptadas por la comunidad como miembros de pleno derecho. Sin embargo, las actitudes y conductas hacia estas personas no siempre son positivas.
Método.  El propósito de esta investigación fue, partiendo de un modelo teórico denominado Escuela de Vida de FUNDOWN, validar un instrumento sencillo que permita recoger información sobre el posicionamiento que muestran adolescentes y jóvenes hacia las personas con discapacidad intelectual. Para ello, se elaboró un cuestionario inicial, que, tras someterse a juicio de expertos y expertas, se aplicó a 276 estudiantes de un Instituto de Educación Secundaria de Murcia (España), a través de una investigación cuantitativa no experimental.
Resultados. Mediante el cálculo de un análisis factorial exploratorio y otro confirmatorio, aplicando el modelo de ecuaciones estructurales, se obtuvo un cuestionario de dos factores.
Discusión y conclusiones.  La validez de constructo y fiabilidad resultaron aceptables.
Evaluation of the “Positive Parent”, a Spanish web-based program to promote positive parenting in a Personal Learning Environment
Authors: Suárez Perdomo Arminda , Byrne Sonia , Rodrigo María José
Published: July 2022

Introduction. The increasing use of online parenting resources offers the opportunity to improve the parenting role through Personal Learning Environments (PLEs). However, there is no evidence concerning the effectiveness of the learning process that takes place in a PLE space.
Method. We evaluated the “Positive Parent” program through the self-assignment of: (a) 143 Spanish-speaking parents to the program modules, following a fixed learning itinerary based on the experiential methodology (Program Group), and (b) 139 parents to complementary multimedia material, following a self-guided, flexible learning itinerary (Visitor Group). For the first goal, both groups were automatically monitored for their pre-posttest completion of the Positive Parenting Scale, resulting in significant improvements in Family involvement, Affection and recognition for the child, Family communication and stress management, and Shared activities in the Program Group only. For the second goal, the Program Group was automatically monitored for Connection time, Connection duration, and Program duration, as well as level of engagement in Forum participation, Diary use, and Making a commitment.
Results. Latent Profile Analysis (LPA) was used to identify patterns of pre-post changes in positive parenting, showing moderate to high improvements in three out of four profiles, that is, for 87.4% of the parents. There was a significant relation between the participants’ decisions in the PLE space and profile membership, with higher engagement in forums, diary use, and making a commitment linked with greater improvements in positive parenting.
Discussion and Conclusion. Given the use of spontaneous enrolment and self-assignment of participants to the program and visitor conditions, we cannot rule out the possibility that individual differences in unknown factors (i.e., motivation) may have affected the results for program effectiveness. However, we provide evidence that the significant improvements in all dimensions of positive parenting were limited to the Program Group, as indicated by the significant group x time interactions, despite the Visitor Group’s exposure to equivalent multimedia materials. For the first time, this evaluation reveals some of the relevant implementation conditions related to the effectiveness of PLEs in non-academic settings. The Positive Parent program provides Spanish-speaking parents with an innovative and successful learning experience to enhance positive parenting that may ultimately promote positive child development and family wellbeing.
Escala de autoestima de Rosenberg (EAR): Análisis de la estructura factorial y propuesta de una nueva versión de solo ítems positivos
Authors: Vilca Lindsey W. , Travezaño-Cabrera Aaron , Santos-Garcia Stephany
Published: July 2022

Introducción.  El objetivo fue evaluar la estructura factorial y proponer una nueva versión de la Escala de autoestima de Rosenberg de solo ítems positivos para superar el efecto de método asociado a los ítems negativos. 
Método. Se planteó una versión A (ítems positivos y negativos) y una versión B (solo ítems positivos). Se recolectó una muestra de 350 universitarios para cada versión.  
Resultados. El AFC evidencia que el modelo unidimensional (A1) de la versión A, no presentan adecuados índices de ajuste. También se encontró que añadir un factor específico para ítems negativos (modelo A2) y otro factor para ítems positivos (modelo A3) no mejora los índices de ajuste. Un modelo bidimensional (modelo A4), tampoco mejorar los índices de ajuste. Respecto al modelo unidimensional de la versión B, este presenta un ajuste superior frente al modelo original (modelo A1)
Discusión y conclusiones. Se concluye que la versión B, una propuesta de solo ítems postivos, mide adecuadamente la autoestima, ya que no tiene ítems negativos y además concuerda con el planteamiento original de Rosenberg.
The optimum conditions of Titanium Recovery process from the Iraqi Bauxite Ore
Authors: Rashid Waleed T. , Ahmad Baqer A. , Jumaah Ajheen H.
Published: July 2022

The present work is especially concerned with the Iraqi bauxite ore that includes 4.1% of titanium element (Ti). The goal of this study is to investigate the effect of various parameters (concentration of acid, ratio of solid: liquid, stirring speed, contact time, and temperature) in order to determine the best conditions for the leaching and extraction of titanium element. All tests of leaching were conducted with different acids (HNO3, H2SO4, and H3PO4) with a ratio of solid: liquid from (1: 100) to (1: 8), the temperature of reaction from (25°C) to (50°C), period of time from (30 min) to (120 min), and speed of stirring from (400 rpm) to (1200 rpm). The best conditions were determined at (1: 100) solid: liquid ratio, (50°C) temperature, (4 M) HNO3 concentration, and (900 rpm) stirring speed. While, the titanium extraction was from leached solution by (trioctylphosphine oxide) (TOPO), tri-n-butyl phosphate (TBP), and di-2- ethylhexyl phosphoric acid (D2EHPA) dissolved in kerosene) with an organic/aqueous ratio of (1/1, 1/2, 1/3, 2/1, and 3/1); temperature of reaction and period of time are correspondingly from (25°C) to (55°C) and from (8 min) to (15 min), and speed of stirring (400 rpm). The best conditions were obtained when using (55°C) temperature, (50%) TOPO concentration, (15 min) contact time, (400 rpm) speed of stirring and (1/3) O/A ratio.
Further evidence for Cretaceous wildfires: macro-charcoal from the Malha Formation at Wadi Budra, west-central Sinai, Egypt
Authors: El Atfy H. , Kora M. , Spiekermann R. , Jasper A. , Uhl D.
Published: July 2022

Fossil evidence for wildﬁres, in form of fossil charcoal, is known from a large number of Cretaceous localities worldwide and it has repeatedly been argued that wildﬁres were connected to the evolution and radiation of angiosperms during this period. The present study provides new evidence (in form of macro-charcoal) for the occurrence of wildﬁres during deposition of the Lower Cretaceous (pre-Aptian) Malha Formation at Wadi Budra of the Sinai Peninsula, Egypt. Despite growing evidence for the worldwide occurrence of wildﬁres during the Cretaceous, the available database for pre-Aptian wildﬁres is still rather scarce for large regions when seen on a global scale, hampering causal interpretations concerning the interactions between ﬁre ecology and the evolution of ecosystems during these stages.
Case study in the Northern Cape (Loopeng area), South Africa, confirming occurrence of a collapsible sand soil structure in transported soils
Authors: Stapelberg F.D.J.
Published: July 2022

Testing was performed on transported soils belonging to recently deposited sandy-silty soil deposits occurring in and around Loopeng Village, Northern Cape Province, South Africa, in order to determine the occurrence and order of magnitude of a collapsible sand soil structure. Various empirical geotechnical characteristics including: in situ soil proﬁle structure description, particle grading curve and clay content, soil classiﬁcation, soil density and void ratio were compared to collapse potential values determined with oedometer testing, in order to judge the success with which the empirical characteristics can be utilised to predict the occurrence of a collapsible soil structure.

From the results it is clear that a collapsible sand structure exists in the transported soils (both aeolian and ﬁne alluvial) and that the empirical descriptors mostly correctly indicate the occurrence of the particular soil structure when compared to existing studies on collapsible sands. The one descriptor which reﬂects a relatively poor prediction of a collapsible soil structure, namely the in situ soil proﬁle structure description, is considered to be a poor indicator due to erroneous or poor in situ soil structure observations. These poor observations result from unfavourable local conditions namely dry, dusty soil conditions and very brief intact standup time of test pit side walls.
Fatores de risco e possibilidades terapêuticas para a Síndrome dos Ovários Policísticos
Authors: Ribeiro Sara Cristina Barbosa , Novais Danielle Fiorin Ferrari , Freitas Fabiana Cristina Ludgerio de , Santos Gabriela Brito , Silva Mayra Heringer Motta Costa e , Almeida Markellen Thana Souza , Vieira Brenda Gomes
Published: July 2022

Objetivo: Ressaltar e revisar os principais fatores de risco para a Síndrome dos Ovários Policísticos (SOP) e explorar os métodos terapêuticos capazes de promover uma melhora na qualidade de vida das pacientes. Revisão bibliográfica: É possível verificar a abordagem das suas principais alterações fisiopatológicas, sendo a hipersecreção de LH patognomônica da doença e, em consequência, o aumento de hormônios androgênicos. A obesidade, o desequilíbrio hormonal, o aparecimento precoce de pelos e o baixo peso em recém-nascidos e o processo de resistência à insulina são descritos como alguns dos fatores predisponentes dessa patologia. A SOP cursa com manifestações clínicas variadas dos sistemas endócrino e ginecológico, podendo se somar a sinais e sintomas do sistema cardíaco e psicológico. Sua terapêutica deve ser baseada na sintomatologia, conforme a individualidade de cada paciente, buscando benefícios na vida reprodutiva e mudança no estilo de vida para melhor promoção de saúde das pacientes. Considerações finais: O artigo conclui que a Mudança do Estilo de Vida (MEV), com a melhora da alimentação e a prática de exercícios físicos, é a base terapêutica para essa síndrome. Aliada ao MEV, a Metformina tem mostrado bons resultados nos transtornos menstruais e indução ovulatória, importante na vida reprodutiva dessas mulheres.
Scrambler Therapy Enhances Quality of Life in Cancer Patients in a Palliative Care Setting: A Randomised Controlled Trial
Authors: Kashyap Komal , Singh Vishwajeet , Dwivedi Sada Nand , Gielen Joris , Bhatnagar Sushma
Published: July 2022

Objectives:

Given the known side effects of opioids and the negative impact of these side effects on quality of life (QOL), there is a need for therapies that can reduce opioid intake and improve QOL in patients suffering from cancer pain. Scrambler therapy (ST) is a neuromodulatory therapy that has been shown to reduce cancer pain, but its effect on QOL is not well understood. This study intended to evaluate the efficacy of ST for enhancing QOL in cancer patients through minimising pain and opioid intake.

Material and Methods:

This was a randomised controlled trial including 80 patients with head, neck and thoracic cancer. In both arms, patients were given pain management drugs following the WHO analgesic ladder for ten consecutive days. In the intervention arm each day ST was given. Pain, morphine intake, and QOL (WHOQOL-BREF) were assessed.

Results:

All domains of QOL improved significantly in the intervention arm in comparison to the control arm. In comparison to baseline, pain improved in both the intervention and the control arm on day 10 and at follow-up. However, QOL significantly improved in the intervention arm, while morphine intake decreased. In the control arm, QOL deteriorated, while morphine intake increased.

Conclusion:

ST significantly improved QOL. Since the increase in QOL took place along with a significantly lower morphine intake, the improvement in QOL may not only be explained by lower pain scores but, also, by a reduced intake of morphine, because the lower dosages of morphine will decrease the likelihood of side effects associated with the drug.
La traduction allemande du Cours de linguistique générale et sa diffusion dans les pays germanophones (1916-1935)
Authors: SOFIA Estanislao
Published: July 2022

Le Cours de linguistique générale de Saussure fut publié en mai 1916. Les deuxéditeurs, Ch. Bally et A. Sechehaye, se sont aussitôt efforcés d’en assurer une diffusionaussi large que possible en sollicitant des comptes rendus et en cherchant desmaisons d’édition qui voudraient publier des traductions. Dans ce contexte, l’histoirede la diffusion et de la traduction du Cours en Europe centrale, pendant la Premièreguerre mondiale et dans les années suivantes, est particulièrement intéressante.Basée sur l’exploitation des archives de Bally et de Sechehaye, conservées àGenève, la présente contribution vise à éclaircir le processus difficile de diffusiondu CLG dans les pays germanophones et à retracer les étapes de l’élaboration de latraduction allemande du CLG par H. Lommel, entreprise dans laquelle L. Gautier ajoué un rôle crucial.
On the early stages of the reception of the Saussurean concept of semiology in Russia
Authors: Velmezova Ekaterina
Published: July 2022

The concept of semiology introduced in the Course in General Linguistics attractedattention in Russia very early on. This concept was perceived by the Russian linguistsas a continuation of a long tradition of research and not as an innovation. Themore politically and ideologically charged the texts were, the more critically theCourse in General Linguistics, and to a larger extent Saussure and semiology, wereperceived in Russia in the 1920s-1930s.
De Saussure à Sapir: la linguistique russe récente
Authors: Alpatov Vladimir
Published: July 2022

La linguistique russe contemporaine se caractérise par un nombre de traits particuliers.Le générativisme en URSS et en Russie ne s’est pas largement propagé.Dans le même temps, on se distancie des principes promulgués par F. de Saussure,qui, tout en élargissant la sphère d’étude de la linguistique au profit de la synchronie,l’a restreinte, en attribuant le fonctionnement de la langue [jazyk] à la parole[reč’], dont le rôle a, dans sa conception, une place périphérique. Dans la linguistiquerusse contemporaine, au contraire, les questions du fonctionnement de lalangue [jazyk] se trouvent au centre de l’attention: on peut se référer à la pragmatique,à l’étude des différentes «visions du monde» [kartina mira], etc. Si, avec unetelle approche, les frontières de la linguistique s’élargissent, il reste difficile de savoiroù les linguistes doivent s’arrêter lors d’un tel élargissement; le niveau de rigueuret de vérifiabilité des résultats a été revu drastiquement à la baisse.
“This eternal wanderer”: A non-dogmatic reading of Saussure
Authors: John Josef
Published: July 2022

Ferdinand de Saussure’s Cours de linguistique générale (1916) has been widelyreceived as a dogmatic text, putting forward a reductivist conception of the languagesystem. Yet there are grounds for reading it very differently, as Roman Jakobson(1969) did when writing of Saussure’s “dynamic repugnance toward the‘vanity’ of any ‘definitive thought’”. Henri Meschonnic blamed “structuralists” (alabel which, of course, gets applied to Jakobson himself) for turning Saussure’slinguistics of the continuous into a dogmatic “scientism of the discontinuous”.Meschonnic’s list of structuralist distortions of Saussure is the framework for theargument presented here in favour of a non-dogmatic reading of the Cours.
La question des emprunts dans le travail terminologique soviétique des années 1920-1930
Authors: Simonato Elena
Published: July 2022

Notre article présente une problématique qui ressurgit couramment dans les débats menés par les linguistes soviétiques, celle de l’emprunt. Je dégage les enjeux profonds que cache le discours sur les emprunts dans l’URSS des années 1920 et 1930, en montrant que ce qui semble à première vue relever d’une discussion technique constitue en réalité une étape importante dans le développement de l’histoire de la linguistique, puisque ce discours renvoie à des questions qui dépassent le domaine linguistique pour entrer dans la politique et la sociologie.
Préface
Authors: Moret Sébastien
Published: July 2022

L’année 2017 fut doublement jubilaire pour l’espéranto. Le centième anniversaire de la mort de son créateur, Lazare Louis Zamenhof (1859-1917), coïncidait en effet avec les 130 ans de la publication du premier manuel dans lequel Zamenhof présenta pour la première fois en 1887 la «langue internationale du Dr Esperanto»1. Cette année particulière fut l’occasion de plusieurs manifestations commémoratives, que ce fût à un niveau local ou international, comme la décision de l’UNESCO d’intégrer le centième anniversaire de la mort de Zamenhof dans la liste des anniversaires à commémorer en 20172. D’une certaine manière, c’est dans cette veine commémorative que souhaite se placer le présent recueil, avec plusieurs contributions consacrées à l’espéranto, à son histoire et à son évolution. Mais ce numéro se veut avant tout et surtout une ouverture sur le monde des langues artificielles (on préfère aujourd’hui parler de langues planifiées pour éviter le côté péjoratif que peut avoir l’adjectif artificiel) en général et sur la science qui s’en occupe, à savoir l’interlinguistique. C’est là une première pour les Cahiers de l’ILSL.
Alba : le blanc peint au fil du temps romain
Authors: Fuchs Michel E. , Spühler Alexandra
Published: July 2022

Une couleur qui n’en est pas une. Mélangez le rouge, le vert et le bleu et, lumineux, le blanc apparaît. Le latin le désigne par l’adjectif albus, terme générique que l’on ne retrouve pas sous cette forme lorsqu’il s’agit de décrire le blanc une fois mis en oeuvre. Il est vrai que ce ne sont pas les théoriciens qui usent de la couleur, mais ceux qui en vivent, les artistes et les artisans au fait du pigment et de la teinture. Il convient de citer Goethe :1 « Peindre de manière claire n’est pas la même chose que produire une image blanche comme de la craie ». C’est toute la confrontation entre la sensation du blanc et l’intervention de la lumière pour sa transparence qui est ici sous-jacente. Le blanc est la couleur du soleil pour Empédocle, porté par l’effluve du feu, l’un des quatre éléments aux racines du monde.2 Il est l’étendard de la faction des albati aux jeux du cirque. Il est le signe de l’hiver. Le blanc habille les morts, nous dit Artémidore.3 C’est la couleur de la toge, marque de la dignité citoyenne. Alba, le vêtement des élus.
AMOUR Une étymologie apparemment évidente...
Authors: Schaller Ga¨ëtan
Published: July 2022

Quoi de plus évident que de faire l’étymologie du mot amour pour déclarer notre amour à la linguistique historique, car dans ce petit mot se cache toute la beauté de notre discipline. Au premier abord pour un oeil inexpérimenté, tout est en effet évident : le mot français amour, m. vient directement du latin am or, -oris m., qui n’aurait subi qu’une simple diphtongaison qui a ensuite été monophtonguée. Mais rien n’est aussi simple en étymologie – tout comme en amour – et là est tout l’intérêt de la linguistique historique comparée : chercher ce qui ne se voit pas au premier regard.
ΑΘΕΝΑΙΑ / ΑΙΑΣ
Authors: Gerleigner Georg Simon
Published: July 2022

That the placement of name inscriptions (letter-chains naming figures or, in rare instances, other pictorial elements) in Greek vase-painting followed certain conventions was noticed early by scholars. In his seminal Non-Attic Greek Vase Inscriptions, Rudolf Wachter succinctly described two main “principles of labelling” : the “starting-point principle” and the “direction principle”.1 While these conventions allow for some variation which is mainly determined by the availability of space, the basic rule of the starting-point principle is that a name is placed close (but preferably not too close) to the figure it refers to – often as close to the head as possible –, with the first letter of the inscription always being closest to a figure’s head (the only exception to that are cases where the name is in its whole width placed horizontally above the head). This also determines the direction of the writing : if the name is placed to the right of (the head of) a figure, the writing runs from left to right, and vice versa ; as a consequence of this direction principle, the “feet” of the letters face the figures they belong to. The rationale behind these long-running and overwhelmingly consistently observed conventions followed by vase-painters presumably was to make clear to the viewer in an unambiguous way which inscription referred to which figure – otherwise (and sometimes still, despite adherence to the conventions) something not easily achieved in many images teeming with figures and letters. In this contribution, I would like to present a – to my knowledge singular – case of a name inscription that plays with these conventions in a spectacular way which epitomises the ingenuity of some craftsmen in exploiting the specific potential of the combination of writing and imagery which inscriptions in Greek vase-paintings represent.
Pour en finir avec † Caius !
Authors: Aberson Michel
Published: July 2022

Le prénom romain †Caius n’existe pas. Ou… presque.C’est chose bien connue ; et pourtant l’on trouve ce monstre onomastique fréquemment mentionné de nos jours, non seulement – ce qui est regrettable mais, comme on va le voir, s’explique assez aisément – dans des travaux d’étudiant-e-s, des sous-titres de films ou des bandes dessinées (fig. 1), mais également dans certaines appellations très sérieuses et dans une partie de la littérature scientifique.
Ex cathedra : en parcourant l’histoire de l’emprunt « aller-retour » gr. a. καθέδρα – gr. mod. καρέκλα à travers le latin et les dialectes italiens
Authors: Dell'Oro Francesca
Published: July 2022

Si l’interlinguistique s’intéresse aux phénomènes de contact entre langues (par ex. l’emprunt) et privilégie une approche diachronique limitée dans le temps (par ex. processus d’intégration et acclimatation de l’emprunt), les historiens des langues s’intéressent au changement sur une plus longue durée, mais souvent n’approfondissent pas les phénomènes de contact. Je tâcherai ici d’intégrer les deux perspectives afin de mieux comprendre l’histoire du mot grec moderne standard καρέκλα « chaise ».
Cucumis, σίκυος, ‘concombre’
Authors: Capponi Matteo
Published: July 2022

Un concombre ? C’est plutôt une couronne de fleurs qu’on attendrait pour un hommage. A la rigueur une couronne d’olivier, de laurier ou de céleri, comme pour un athlète triomphant. Mais un concombre ? Patience cependant. La suite de ce discours montrera que le concombre (σίκυος grec et cucumis latin) n’a rien d’anodin. Il peut être source d’inspiration aussi bien pour le linguiste que pour le poète et le gourmet. Mieux encore : il révèle leur talent. C’est ce que nous prouverons à travers ces lignes, saluant au passage la capacité du professeur Wachter à jongler avec les trois rôles, lui qui cultive l’art des Muses et le goût de la cuisine autant que la science des mots.
Honorare e(s)t onerare
Authors: Bovet Dylan
Published: July 2022

Ehren : beschweren. Cette équation proverbiale pose, en allemand, les termes du problème : l’honneur est un poids, rendre hommage également. Comment donc s’en acquitter ? A travers la paronomase et l’association des idées ce Sprichwort fait écho à une association similaire, en latin, entre les verbes honorare et onerare. Pour cette raison, je traite ici non pas d’un mot unique, mais de deux termes aux relations complexes sur tous les plans graphique, phonétique et sémantique, qui participent de leur confusion. En touchant à la fois à la littérature classique et à l’épigraphie, notamment versifiée, cette note sur deux Wörter au coeur de la notion de commémoration, reflète les intérêts multiples de notre collègue. Et selon la formule consacrée, son imposant cursus honorum universitaire rend cet hommage d’autant plus difficile.
Emprunt et/ou recréation ? A propos de fr. sémantique
Authors: Rousseau Nathalie
Published: July 2022

C'est l'enchevêtrement d’héritages et d’emprunts réciproques, auquel s’ajoute, pour la langue intellectuelle entendue de manière large, un « contact intense et continu » des Modernes avec les textes anciens, que nous souhaiterions illustrer d’un exemple précis : le terme fr. sémantique nous paraît ainsi digne d’intérêt non seulement parce qu’il désigne depuis un siècle, sous forme substantivée, l’une des branches de la linguistique, qui se consacre précisément au sens des [vøːrtər] qui constituent le sujet de ce volume, mais aussi parce qu’il a récemment connu, sous forme adjectivale, un spectaculaire succès dans l’expression Web sémantique (angl. Semantic Web), et illustre d’autant mieux la fécondité de la présence des langues anciennes dans nos langues modernes.
VITUDURON
Authors: Jaques Albin
Published: July 2022

En 1992, quand le groupe de rock bernois Züri West décida de nommer son album live « Wintertour », il ajouta plaisamment une nouvelle étymologie populaire à un polionyme déjà victime d’une attraction paronymique. En effet, la sixième ville helvétique n’a pas a priori plus d’affinités avec la saison hivernale qu’avec les autres, et la Thur, affluent du Rhin éponyme du canton de Thurgovie, coule plusieurs kilomètres au nord de Winterthour.Pour le savoir, nous connaissons heureusement son nom dans l’Antiquité grâce à deux attestations du iiie s. apr. J.-C. Tout d’abord dans l’Itinéraire d’Antonin qui nous apprend qu’alors pour aller de Bregenz (Brigantia) à Strasbourg (Argentorato), on passait par Vitudoro entre Pfyn (Finibus) et Windisch (Vindonissa). Et à peu près à la même époque, précisément en 294 (d’après les titulatures impériales), une inscription évoque la reconstruction du Murus Vitudurensis financée par les premiers tétrarques.
Apprendre à expliquer
Authors: De Gaulmyn Marie-Madeleine
Published: July 2022

[Ce texte n'a pas de résumé].
Analyse morpho-syntaxique du français et enseignement assisté par ordinateur
Authors: Renard Karen
Published: July 2022

[Ce texte n'a pas de résumé].
Présentation
Authors: Grosjean François
Published: July 2022

[Ce texte n'a pas de résumé].
Apprentissage par l'image ou à l'image ?
Authors: Jeanneret René
Published: July 2022

[Ce texte n'a pas de résumé].
Phénomènes de régression de la compétence linguistique dans l'apprentissage d'une langue seconde en situation scolaire
Authors: Merkt Gérard
Published: July 2022

[Ce texte n'a pas de résumé].
bon usage, c'est mon usage: normes linguistiques et procédés de correction de la rédaction
Authors: Näf Anton
Published: July 2022

[Ce texte n'a pas de résumé].
Avant-propos
Authors: Rubattel Christian
Published: July 2022

[Ce texte n'a pas de résumé].
Comparaisons littérales, comparaisons non littérales et métaphores
Authors: Reboul Anne
Published: July 2022

[Ce texte n'a pas de résumé].
Le système des pronoms personnels en français contemporain : le problème de la référence
Authors: Reboul Anne
Published: July 2022

[Ce texte n'a pas de résumé].
Bilinguisme, exolinguisme et acquisition: rôle de L1 dans l'acquisition de L2
Authors: Py Bernard
Published: July 2022

[Ce texte n'a pas de résumé].
dichotomie synchronie-diachronie chez Saussure et Benveniste: fondements et reformulations
Authors: Girod-Doebelin Anne-Christine
Published: July 2022

[Ce texte n'a pas de résumé].
bilinguisme particulier : français/langue des signes
Authors: Dunant-Sauvin Claire , Chavaillaz Jean-François
Published: July 2022

[Ce texte n'a pas de résumé].
Comment un pays monolingue voit-il le bilinguisme?
Authors: Veraguth-Joaquim Angela
Published: July 2022

[Ce texte n'a pas de résumé].
Surdité: déficience sensorielle innée et mutité linguistique acquise - (ré)apprentissages langagiers et construction d'un sujet sourd parlant
Authors: Millet Agnès
Published: July 2022

[Ce texte n'a pas de résumé].
L'apport de la coarticulation dans la perception de consonnes occlusives et constrictives
Authors: Gigandet Murielle
Published: July 2022

[Se référer au PDF pour le résumé].
Caractérisation des structures de performance en français
Authors: Monnin Pascal
Published: July 2022

[Se référer au PDF pour le résumé].
Choix des langues et alternance codique chez le bilingue en situations de communication diverses : étude expérimentale
Authors: Weil Sonia
Published: July 2022

[Se référer au PDF pour le résumé].
Perception catégorielle et sujets cérébro-lésés : données préliminaires
Authors: Klose Karin
Published: July 2022

[Se référer au PDF pour le résumé].
Perception catégorielle et troubles du langage écrit
Authors: Lambert-Dutoit Florence
Published: July 2022

[Se référer au PDF pour le résumé].
Automatic correction of French prose written by English native speakers: an LFG approach
Authors: Cornu Etienne
Published: July 2022

[Se référer au PDF pour le résumé].
Evaluating second language grammar checkers
Authors: Tschichold Cornelia
Published: July 2022

[Se référer au PDF pour le résumé].
Selecting English errors made by French-speakers for automatic correction
Authors: Tschumi Corinne , Tschichold Cornelia
Published: July 2022

[Se référer au PDF pour le résumé].
Construction de la référence et stratégies de désignation
Authors: Apothéloz Denis , Reichler-Béguelin Marie-José
Published: July 2022

[Se référer au PDF pour le résumé].
Oral et écrit dans les représentations des enseignants et dans les pratiques quotidiennes de la classe de français
Authors: Pietro Jean-François de , Wirthner Martine
Published: July 2022

[Se référer au PDF pour le résumé].
Interactions verbales en accès à la littérature
Authors: Delefosse J.-M. Odéric
Published: July 2022

[Se référer au PDF pour le résumé].
Conscience linguistique et traitement de l'information écrite
Authors: Gombert Jean Emile , Martinot Clara , Nocus Isabelle
Published: July 2022

[Se référer au PDF pour le résumé].
Alternance des langues en classe: pratiques et représentations dans deux situations d'immersion
Authors: Matthey Marinette , Moore Danièle
Published: July 2022

[Se référer au PDF pour le résumé].
Comparaison des stratégies discursives d'étayage dans un conte et un récit d'expériences oraux
Authors: Rosat Marie-Claude
Published: July 2022

This paper compares different strategies (questions, comments, reformulations, and repetitions) used by an adult in a situation of dialogue with language impaired and control preschool children. Two types of coproduction (a tale and a personal account) are analysed. The stability of the distribution of the various strategies in both situations of dialogue is the sign of the stability of the interaction. The plurifonctionality of these four strategies is the sign of a difference in managing the enunciative positions, according to the group of locutors and to their ages.
productions textuelles d’enfants dysorthographiques et non dysorthographiques sont-elles comparables?
Authors: Weck Geneviève de
Published: July 2022

Writing does not consist merely in spelling, but also includes a textual dimension that requires several years of learning. And yet, in speech and language therapy, children are generally reported, in the field of written production, only because of their difficulties with spelling. What of their ability to produce a written text, then?
This issue underlies an exploratory research lead with children, who are in their third and fourth year of primary school, with or without dysorthographia. These were placed in several writing situations (spelling tests and text writing). Some results concerning the writing of a story on the basis of given pictures are presented. They show that there are both divergences (length of the texts, reconstruction of the content and use of some linguistic units) and convergences (types of texts produced, use of verb tenses) between the two types of children.
Accanto
Authors: Лахенман Х.
Published: July 2022

Настоящая публикация представляет собой перевод вступительного слова Хельмута Лахенмана перед исполнением его композиции «Accanto» на концерте 23 ноября 1982 года в Цюрихе. Первая публикация: Lachenmann H. Accanto // Musik-Konzepte. Band 61/62: Helmut Lachenmann // hrsg. von H.-K. Metzger und R. Riehn. München: edition text+kritik, 1988. S. 67-74.

This publication presents a translation of Helmut Lachenmann's introductory note to the performance of his work Accanto at the concert on 23 November 1982 in Zurich. First publication: Lachenmann H. Accanto // Musik-Konzepte. Band 61/62: Helmut Lachenmann // hrsg. von H.-K. Metzger und R. Riehn. München: edition text+kritik, 1988. S. 67-74.
Alexander Khubeev Shares His Experience of Working in Germany
Authors: Амрахова А.А. , Хубеев А.М.
Published: July 2022

В данном интервью композитор А. Хубеев делится впечатлениями о месяцах, проведенных им в Германии в качестве стипендиата Берлинской академии искусств. Важнейшим аспектом беседы становится констатация изменений, произошедших в современном музыкальном искусстве: распространение мультимедийной технологии, изменение самого музыкального материала. А. Хубеев подчеркивает общую ситуацию многообразия подходов к сочинению музыки. Своеобразие момента заключается также в том, что между приверженцами разных направлений нет антагонизма: сегодня любое «стилевое поветрие» имеет право на жизнь, не дожидаясь своего признания в парадигме уже сложившихся эстетических категорий.

In this interview, the composer A. Khubeev shares his impressions of the months he spent in Germany as a fellow of the Berlin Academy of Arts. The most important aspect of the conversation is the composer’s assertion that the contemporary art of music have undergone some notable changes: the ubiquity of multimedia technology, the change in musical material. A. Khubeev emphasizes the overall diversity of approaches to the composing of music. Besides, the current moment is specifically featured by the fact that there is no antagonism between the followers of different trends: any kinds of “stylistic crazes” of today have their right to exist, without waiting for their recognition within the paradigm of already established aesthetic categories.
Philippe Leroux: “To Create a Sensation of Continuum”
Authors: Купровская Е.О. , Леру Ф.
Published: July 2022

В беседе с Е. Купровской французский композитор Филипп Леру вспоминает о своей работе в IRCAM, о царящем там творческом духе. Композитор также рассказывает о процессе сочинения музыки, который трактует как предварительное «ви́дение» звукового потока и придание ему энергетической, или морфологической, логики, и объясняет свой повышенный интерес к буквам как концептуальной основе музыкального сочинения.. Леру делится своим опытом преподавания композиции и выражает оптимизм по поводу социального положения композитора во Франции.

In a conversation with E. Kouprovskaia, the French composer Philippe Leroux recalls his work at the IRCAM, and the creative spirit that reigns there. The composer also talks about the process of composing music, which he interprets as a preliminary “vision” of the sound stream and giving it an energetic, or morphological, logic, and explains his increased interest in letters as the conceptual basis of musical composition. Leroux shares his experience of teaching composition and expresses his optimism about the social position of a composer in France.
A novel blood brain barrier-permeable IRE1 kinase inhibitor for adjuvant glioblastoma treatment in mice.
Authors: Pelizzari-Raymundo Diana , Doultsinos Dimitrios , Pineau Raphael , Sauzay Chloé , Koutsandreas Thodoris , Carlesso Antonio , Gkotsi Elena , Negroni Luc , Avril Tony , Chatziioannou Aristotelis , Chevet Eric , Eriksson Leif A. , Guillory Xavier
Published: July 2022

Inositol Requiring Enzyme 1 (IRE1) is a bifunctional serine/threonine kinase and endoribonuclease. It is a major mediator of the Unfolded Protein Response (UPR), which is activated during endoplasmic reticulum (ER) stress. Tumor cells experience ER stress due to adverse microenvironmental cues such as hypoxia or nutrient shortage and high metabolic/protein folding demand. To cope with those stresses, cancer cells utilize IRE1 signaling as an adaptive mechanism. Here we report the discovery of novel IRE1 inhibitors identified through a structural exploration of the IRE1 kinase domain. We first characterized the candidates in vitro and in cellular models. We showed that all molecules inhibit IRE1 signaling and sensitize glioblastoma cells to the standard chemotherapeutic temozolomide (TMZ). From these inhibitors, we retained a Blood-Brain Barrier (BBB) permeable molecule (Z4P) and demonstrated its ability to inhibit Glioblastoma (GB) growth and to prevent relapse in vivo when administered together with TMZ. These results support the attractiveness of IRE1 as an adjuvant therapeutic target in GB. We thus satisfy an unmet need for targeted, non-toxic, IRE1 inhibitors as adjuvant therapeutic agents against GB.
Discovery of XL01126: A Potent, Fast, Cooperative, Selective, Orally Bioavailable and Blood Brain Barrier Penetrant Prote-olysis Targeting Chimera Degrader of Leucine Rich Repeat Kinase 2
Authors: Liu Xingui , Kalogeropulou Alexia , Domingos Sofia , Makukhin Nikolai , Nirujogi Raja , Singh Francois , Shpiro Natalia , Saalfrank Anton , Sammler Esther , Ganley Ian , Moreira Rui , Alessi Dario , Ciulli Alessio
Published: July 2022

Leucine Rich Repeat Kinase 2 (LRRK2) is one of the most promising targets for Parkinson’s Disease. LRRK2 targeting strategies have primarily focused on Type 1 kinase inhibitors, which however have limitations as the inhibited protein can interfere with natural mechanisms which could lead to undesirable side effects. Herein, we report the development of LRRK2 Proteolysis Targeting Chimeras (PROTACs), culminating in the discovery of degrader XL01126, as an alternative LRRK2 targeting strategy. Initial designs and screens of PROTACs based on ligands for E3 ligases von Hippel-Lindau (VHL), Cereblon (CRBN), and cellular inhibitor of Apoptosis (cIAP) identified the best degraders containing thioether-conjugated VHL ligand VH101. A second round of medicinal chemistry exploration led to qualifying XL01126 as a fast and potent degrader of LRRK2 in multiple cell lines, with DC50 values within 15-72 nM, Dmax values range from 82-90%, and degradation half-lives span from 0.6h to 2.4h. XL01126 exhibits high cell permeability and forms a positively cooperative ternary complex with VHL and LRRK2 (α=5.7), which compensates for a substantial loss of binary binding affinities to VHL and LRRK2, underscoring its strong degradation performance in cells. Remarkably, XL01126 is orally bioavailable (F=15%) and can penetrate the blood brain barrier after either oral or parenteral dosing in mice. Taken together, these experiments qualify XL01126 as a suitable degrader probe to study non-catalytic and scaffolding functions of LRRK2 in vitro and in vivo and offer an attractive starting point for future drug development.
Phytochemical Drug Discovery for COVID-19 Using High-resolution Computational Docking and Machine Learning Assisted Binder Prediction
Authors: Wang Zirui , Belecciu Theodore , Eaves Joelle , Reimers Mark , Bachmann Michael , Woldring Daniel
Published: July 2022

The COVID-19 pandemic has resulted in millions of deaths around the world. Multiple vaccines are in use, but there are many underserved locations that do not have adequate access to them. Variants may emerge that are highly resistant to existing vaccines, and therefore cheap and readily obtainable therapeutics are needed. Phytochemicals, or plant chemicals, can possibly be such therapeutics. Phytochemicals can be used in a polypharmacological approach, where multiple viral proteins are inhibited and escape mutations are made less likely. Finding the right phytochemicals for viral protein inhibition is challenging, but in-silico screening methods can make this a more tractable problem. In this study, we screen a wide range of natural drug products against a comprehensive set of SARS-CoV-2 proteins using a high-resolution computational workflow. This workflow consists of a structure-based virtual screening (SBVS), where an initial phytochemical library was docked against all selected protein structures. Subsequently, ligand-based virtual screening (LBVS) was employed, where chemical features of 34 lead compounds obtained from the SBVS were used to predict 53 lead compounds from a larger phytochemical library via supervised learning. A computational docking validation of the 53 predicted leads obtained from LBVS revealed that 28 of them elicit strong binding interactions with SARS-CoV-2 proteins. Thus, the inclusion of LBVS resulted in a 4-fold increase in the lead discovery rate. Of the total 62 leads, 18 showed promising pharmacokinetic properties in a computational ADME screening. Collectively, this study demonstrates the advantage of incorporating machine learning elements into a virtual screening workflow.
Reduced Potential Barrier of Sodium-substituted Disordered Rocksalt Cathode for Oxygen Evolution Electrocatalysts
Authors: SINGH ADITYA NARAYAN , Hajibabaei Amir , Ha Miran , Meena Abhishek , Nam Kyung-Wan
Published: July 2022

Cation disordered rocksalt (DRX) cathodes have been viewed as next-generation high energy density materials surpassing conventional layered cathodes for lithium-ion battery (LIB) technology. Grabbing the opportunity of a better cation mixing facility in DRX, we synthesize Na-doped DRX as an efficient electrocatalyst toward oxygen evolution reaction (OER). This novel OER electrocatalyst generates a current density of 10 mA cm-2 at an overpotential (η) of 270 mV, Tafel slope of 67.5 mV dec-1, and long-term stability >5.5 days superior to benchmark IrO2 (η = 330 mV with Tafel slope = 74.8 mV dec-1). This superb electrochemical behavior is well supported by experiment and sparse Gaussian process potential (SGPP) machine learning-based search for minimum energy structure. Moreover, as oxygen binding energy (OBE) on the surface closely relates to OER activity, our density functional theory (DFT) calculations reveal that Na-doping assists in facile O2 evolution (OBE = 5.45 eV) compared with pristine-DRX (6.51 eV).
Planet compatible pathways for transitioning the chemical industry
Authors: Meng Fanran , Wagner Andreas , B. Kremer Alexandre , Kanazawa Daisuke , J. Leung Jane , Goult Peter , Guan Min , Herrmann Sophie , Speelman Eveline , Sauter Pim , Lingeswaran Shajeeshan , M. Stuchtey Martin , Hansen Katja , Masanet Eric , C. Serrenho André , Ishii Naoko , Kikuchi Yasunori , M. Cullen Jonathan
Published: July 2022

Chemical products, such as plastics, solvents, and fertilizers, are essential for supporting modern lifestyles. Yet, producing, using and disposing of chemicals creates adverse environmental impacts which threaten the industry's license to operate. This study presents seven planet compatible pathways towards 2050 employing demand-side and supply-side interventions with total investment costs of US$1.2-3.7 billion. Resource efficiency and circularity interventions reduce global chemicals demand by 23–33% and are critical for mitigating risks associated with using fossil feedstocks and carbon capture and sequestration, and constraints on available biogenic and recyclate feedstocks. Replacing fossil feedstocks with biogenic/air-capture sources, shifting carbon destinations from atmosphere to ground, and electrifying/decarbonizing energy supply for production technologies, could enable net negative emissions of 200 MtCO2eq yr-1, while still delivering essential chemical-based services to society.