bluuebunny/crossref_metadata_2025 huggingface dataset:
Importance and contribution of surface water and groundwater resources in GDP growth and economic structure of Ho Chi Minh City
Authors: Nguyen Hung Thanh , Ton Anh Nu Phuong , Nguyen Hang Thi Cam
Published: May 2019

Water is essential to life, making its total economic value immeasurable. At the same time water is a finite resource, and one for which competition is likely to increase as the Ho Chi Minh City’s economy grows. Driven by this heightened competition, the economic value of water will rise, and decision-makers in both the private and the public sectors will need information that can help them maximize the benefits derived from its use. This report is an initial step toward (1) raising awareness of water’s importance to our city economic welfare, and (2) assembling information that is critical to sustainably managing the city’s water resources. It emphasizes the analysis of the contribution of two important inputs to economic sectors: labor and water use; calculate the index of economic water productivity and show the necessary interventions in the face of water shortage.
TO STUDY THE PREVALENCE AND EFFECTS OF GROUP B STREPTOCOCCAL INFECTION AT 35-37 WEEKS OF GESTATION IN NORMAL ASYMPTOMATIC PRIMIGRAVIDA
Authors: Mehathab Dr. Shaik , Rekha Rao Dr. PM.
Published: May 2019

Background: The importance of GBS emerged in 1937, when three maternal deaths occurred out of seven GBS (Group B Streptococcal) related puerperal sepsis cases, until then GBS is regarded just as commensal. Puerperal sepsis has been described for centuries. Ancient Indian texts in 1500 B.C have recorded that good hygiene leads to a reduction in the perinatal disease. Streptococcus is a causative organism for puerperal sepsis.

Materials and Methods: Primigravida women of 35-37 weeks of gestation attending the antenatal op and wards of Government maternity hospital, Tirupati, based on the inclusion and exclusion criteria.

Duration of study: July 2012- October 2013.

Results: The prevalence of group B streptococcal colonization in asymptomatic primigravida in the study population is 7%. The maternal colonization with group B streptococci is not related to age of the patients.

Keywords: Group B Streptococcal, Vaginal colonization, Primigravida, Kadapa
Rethinking Indigenous Suicide
Authors: Ansloos Jeffrey
Published: May 2019

Suicide is one of the most significant issues facing Indigenous communities throughout Canada. The rate of Indigenous deaths by suicide is severely disproportionate to that of the general public. While the last three decades have seen substantial investments in suicidology research within the Canadian context, rates of Indigenous deaths by suicide have remained relatively stable, and little remains known about effective means to reduce Indigenous deaths by suicide. A movement of critical suicidology scholars across health and social sciences is beginning to challenge the mainstream approach of suicidology research and suicide prevention, citing concerns about the ideological and epistemic foundations. In this article, the author highlights how these critiques are relevant to Indigenous contexts. Challenging a range of assumptions, the author considers the need to rethink the ideological foundations of research on Indigenous suicide. Finally, the author considers two methodological projects that are integral to forming a critical approach to Indigenous suicidology research and Indigenous suicide prevention praxis–culturally grounded research and decolonizing research.
I’taamohkanoohsin (everyone comes together): (Re)connecting Indigenous people experiencing homelessness and addiction to their Blackfoot ways of knowing.
Authors: Victor Janice , Shouting Melissa , DeGroot Chelsey , Vonkeman Les , Brave Rock Mark , Hunt Roger
Published: May 2019

Addiction and homelessness are closely related outcomes for many Indigenous Canadians who live with extensive intergenerational trauma caused by residential school and the 60s Scoop. In recent years, the rise of opioid addiction along with related overdoses and mortalities in many parts of Canada has led to what is being called an opioid crisis. (Re)connection to Indigenous ways of knowing and practices are frequently seen as a path to healing; therefore, an innovative grassroots program was developed recently in a southern Alberta city to address addictions and homelessness within a largely Blackfoot population. The program increased access to traditional cultural resources and activities in a visible, downtown location to a population who are among the most marginalized in society. A Two-Eyed Seeing framework was used perform a program evaluation and analyze participant and key informant interviews. The results indicated that attendance connected people with their spirits, inspiring strength and hope for the future, and ameliorated spiritual homelessness. The program formed a safe space where relationships were strengthened, people felt respected, and meaningful activity away from substances was available.
Developing a Science Simulation Program to Teach the Concept of Balance in Physics: Its Development and Application for Gifted Korean Elementary Students of Science
Authors: Park Jeongwoo , Shin Myeong-Kyeong , Shim Han Su , Lee Gyeong-Geon , Lee Sun-Kyung
Published: May 2019

In this study, we focused on the development of a simulation program for a Gifted Education Center in South Korea. We introduced our simulation program, which focuses on the concept of balancing concept in physics, and analyzed students’ reasoning and perceptions. According to Brunner’s EIS (Enactive, Iconic, and Symbolic Representation) theory, the simulation was designed to be abstracted gradually from iconic to symbolic. A simulation in three stages was developed, including game-like, indirect questions such as finding the number of all cases of balance. Three classes of students in grades 5 and 6 consisting of 44 gifted students in Korea participated in this study, and their reasoning and perceptions were analyzed. The results of the analysis of students’ reasoning indicated that more than 70% of students predicted the phenomenon using mathematical models. Some students (17 out of 44 students) used particular strategies to count all cases of balance. Students perceived that the simulation program helped them to understand the phenomenon, considered that the simulation was not difficult and that the lecture, feedback, and teaching materials were satisfactory. Regarding self-participation, students perceived that they experienced new methods for exploring, were made keenly aware of phenomena and principles, made efforts to engage in creative thinking, and actively communicated with their peers through the simulation program. Through this study, we suggest an example of a gifted student program using a simulation and describe its successful application. Simulation activities, which form the context of this research, can lead to research related to computational thinking, which is crucial for our future society. We hope for more discussions to elaborate on and systematize context and methods of computer simulations.
Optimization and Characterization of Tyrosinases from Multi-enzyme Producing Fusarium solani and Fumago sp.
Authors: Odeniyi Olubusola Ayoola , Ogunsanya Adebosola , Unuofin John Onolame
Published: May 2019

Tyrosinase is a copper-containing metalloprotein that catalyzes the oxidation of tyrosine, in particular, L-DOPA to L-Dopaquinone, which are precursors of brown pigments in some wounded eukaryotic tissues. The present study focused on screening, production and characterization of tyrosinase from multi-enzyme producing Fusarium solani B1 and Fumago sp. A total of 25 strains were isolated from rotting wood samples and screened for hydrolytic and oxidative multi-enzyme potentials using different polymeric substrates. The two most consistent strains: Fusarium solani B1 and Fumago sp. B13 were further evaluated for tyrosinase production. Some media cultural parameters and physiological conditions were optimized in order to maximize tyrosinase production. Incubation of Fumago sp. B13 and Fusarium solani B1 for 96 and 144 h in medium containing 2 % and 0.2 % ratios of Glucose and NaNO3 with pH 6 and 7, respectively, was most suitable for tyrosinase production. Characterization of the partially purified tyrosinase from Fumago sp. B13 and Fusarium solani B1 exhibited optimal activities at pH 6-7, 30 °C, and 1 mM Cu2+, respectively, thereby suggesting their potentials for novel biotechnological applications.
5G网络终端接入安全思考
Authors: 史 锦斌 , 李 博
Published: May 2019

第五代移动通信系统（5G）三大典型应用场景分别是增强型移动宽带、高可靠低时延网络和海量连接。5G除了提供超高速的移动互联网应用外，还需要为车联网、物联网（IoT）、工业制造等垂直行业的发展提供稳定可靠的网络接入，为垂直行业的信息化发展提供网络信息基础平台。新技术产生的全新应用场景和服务方式给5G网络的安全带来新的安全需求与风险。网络安全是对整个系统的要求，涉及到终端、接入、传输、核心、应用等多个环节，本文仅就网络终端和接入对安全的要求谈一些自己的思考。
浅析结构性思维在建筑工程中应用
Authors: 王 亚麟
Published: May 2019

在工作、学习中遇到问题总是束手无策，不知从何入手去解决问题。通过结构性思维可以系统的梳理、层层分析，直击问题重点并找出最佳解决方案。最终通过计划，追踪、落实方案从而解决问题。无论在遇到什么问题都会有的放矢、轻松应对。
Kemal Siyahhan (2016). Mülteci, İstanbul: Sel Yayıncılık, (ISBN: 978-975-570-809-6), 191 Sayfa.
Authors: Bilecen Tuncay
Published: May 2019

Kemal Siyahhan (2016). Mülteci, İstanbul: Sel Yayıncılık, (ISBN: 978-975-570-809-6), 191 Sayfa.
Göç(er) Edebiyatı Yazarı Yüksel Pazarkaya ile Söyleşi
Authors: Taş Seda
Published: May 2019

Bu söyleşi, Yüksel Pazarkaya ile davetli konuşmacı olduğu 23-26 Ağustos 2017 tarihleri arasında Atina Harokopio Üniversitesi’nde düzenlenen 5. Göç Konferansı sırasında Dr Seda Taş tarafından gerçekleştirilmiştir (Bkz. www.migrationcenter.org).ABSTRACT IN ENGLISHInterview with Yüksel Pazarkaya, the migra(nt)tion novelistDr Seda Taş conducted this interview with Yüksel Pazarkaya who was an invited speaker at the 5th Migration Conference held from 23 to 26 August 2017 at Harokopio University, Athens, Greece. (See. www.migrationcenter.org).
Veri Sunumu: 2016 Yılı İtibarıyla Türkiye’de Hemşehri Dernekleri
Authors: Kayaoglu Aysegul
Published: May 2019

Türkiye’de 1950’lilerde başlayan ve artan bir oranda devam eden şehirleşme ile birlikte kır ve kent arası ekonomik kalkınma farklılıkları, kırsal kalkınma alanında özellikle 1980’ler sonrası benimsenen neo-liberal uygulamalar ve refah politikalarındaki zayıflama, beraberinde sivil toplum kuruluşlarının hem kente göç edenlerin kentlerdeki sosyo-ekonomik uyumlarına olumlu etkilerinin hem de katılımcı kırsal dönüşüm ile ilgili rollerinin ön plana çıkmasına sebep olmuştur. Literatürde özellikle ‘hemşehri dernekleri’ gerek uluslararası gerekse iç göç bağlamında göçmenlere ve göç veren bölgelere olan sosyo-ekonomik katkıları sebebiyle konu edilmiştir. Türkiye gibi iç göçün süreklilik gösterdiği bir ülkede ‘kırsal kalkınmanın yeni girişimcileri’ rolünü üstlenen bu kuruluşlara dair veriler ayrıca önem taşımaktadır. Bu çalışma ile Türkiye’deki hemşehri derneklerinin 2016 yılında il bazındaki dağılımlarına dair verinin sunumu ile birlikte Türkiye’de bu derneklere dair yapılan akademik araştırmalar özetlenmektedir. Bu veriler bize kente göç edenlerin sivil toplum kuruluşu bağlamında sahip oldukları sosyal sermaye birikimine dair de bilgi vermektedir.Hometown Associations in Turkey as of 2016Rapid urbanisation and rural-urban development gap as well as neo-liberal and weakened welfare policies give increasing importance to NGOs for their positive impact on socio-economic integration of immigrants and participatory rural transformation. Hometown associations (HTAs), in particular, receive special consideration in the literature. Data on HTAs -considered the new entrepreneurs of rural development- are especially important in Turkey with continuous internal migration. This study presents a literature review of academic research on HTAs in the country and province-level data on the number of these institutions in 2016. Expectedly, HTAs in Turkey are mainly concentrated in cities with highest migrant inflows such as İstanbul, Ankara and Izmir. Highest number of HTAs, however, are established by emigrants from Sivas, Ankara and Erzurum while emigrants from Hakkari, Yalova, Kilis and Şırnak are behind lowest number of HTAs. The presented data also shed light on social capital accumulation of rural-to-urban migrants in the country.
İstanbul İlçelerinin Nüfus Değişimi ve Kütük Bilgilerinin Analizi
Authors: Sunata Ulaş , Ergül Dila
Published: May 2019

39 ilçesiyle Türkiye’nin en büyük nüfusuna sahip ili İstanbul aynı zamanda Türkiye’nin en çok iç göç alan şehridir. Özellikle kırdan kente göç bağlamında sosyo-ekonomik ve demografik özellikleriyle birçok araştırmaya konu olmuştur. Fakat İstanbul yerleşik nüfusunun Türkiye’nin diğer şehirlerine kayıtlı olma yoğunluğu da önemlidir. Bu çalışmanın amacı 2012 ve 2017 yıllarındaki nüfus değişimini göz önünde bulundurarak İstanbul ilçelerinin ayrıntılı nüfus yoğunluğu ve büyüme analizini yapmak, ilgili faktörleri değerlendirmek, hemşehri ağlarını okumak adına yerleşik nüfus kütük bilgileri bakımından inceleyerek elde edilen örüntüler doğrultusunda ilçe tipolojileri oluşturmaktır. Çalışmanın birinci bölümünde ilgili beş yıllık nüfus değişimlerine göre İstanbul ilçe nüfusları analiz edilmiştir. Ardından her bir ilçe için nüfusa kayıtlı olunan kente göre nüfus büyüme hızlarına bakılarak ilçelerin ağırlıklı olarak barındırdığı hemşehri ağları belirlenmiştir. İkinci bölümde ise ilçeler nüfus değişim özelliklerine göre belirli kategorilere ayrılmış ve bu kategoriler doğrultusunda ilçe tipolojileri oluşturulmuştur..ABSTRACT IN ENGLISHA District Level Analysis of Istanbul’s Population Change (2012-2017)Istanbul having the largest population of Turkey with its 39 districts is the most internal-migrant-receiving city in Turkey. Particularly in the context of rural-to-urban migration, Istanbul has been became a subject of various researches with its socio-economic and demographic features. However, the density of Istanbul’s settled population who registered other cities of Turkey is important. The main aim of this study is to analyse population growth of all districts considering the population change between 2012 and 2017, to evaluate the related factors and to develop a district typology by using the data of settled population according to their family registration in the name of reading the current countryman networks. In the first section of the study, district populations of Istanbul are examined regarding the related five-year change. Afterwards, most repeated countryman networks of all Istanbul’s districts are specified regarding the population growth rate of the registered cities. In the latter section of the study, districts were divided into categories regarding the specific population change features which help to create district typology.
Evaluation of morphological traits, phytochemical compositions and antioxidant properties of watercress leaves
Authors: Sakil MA , Polash MAS , Afrin S , Hossain MA
Published: May 2019

Despite the significant nutritional and health values, watercress (Nasturtium officinale L.) is still insufficiently known and explored leafy vegetables. Being a native crop of Central Asia ensure possibility of watercress to grow under Bangladesh climate.An experiment was conducted during October 2015 with the aim to evaluate the morphological traits, morphological traits, phytochemical compositions and antioxidant properties of the leaves of watercress. The experiment was designed with Completely RandomizedDesign (CRD) with three replications. The results showed, average watercress shoot biomass was 38.60 ± 3.41 g plant-1. In case of leaf pigment composition the chlorophyll a and b was 70.45 ± 11.97 and28.32 ± 4.37 mg 100 g-1 FW. On an average, the increasing order of the nutrients of proximate analysis in fresh sample was fat<ash<carbohydrate<protein<moisture. Besides those, mineral composition and antioxidant properties of watercress leaves were evaluated. Potassium mineral concentration was highest in watercress leaves 278±45% w.b. followed by Calcium 131±13 % w.b. The ascorbic acid was found in highest concentration 70.57±5.78 mg/100g fresh weight. Results also showed 50.42±2.77 mg GAE/g phenols and 0.13±0.03 mg/ml DPPH radicle scavenging activity in watercress.

Progressive Agriculture, Vol. 30, Suppl. 1: 10-16, 2019
Mechanical drying of paddy using BAU-STR dryer for reducing drying losses in Bangladesh
Authors: Alam MA , Saha CK , Alam MM
Published: May 2019

Mechanical intervention in each stage of post-harvest operation of paddy is time demand due to increased cost of labour as well as shifting of labour from agriculture to non-agriculture sector. Mitigation of food demand of rapidly increasing population is becoming a major future challenge in agriculture sector. Drying of paddy is important for maintaining quality and long term storage of paddy. Among the drying methods, traditional sun drying is the most common practice in Bangladesh. Normally, farmers use yard in wet season (Boro & Aus) and field in dry season (Aman) to dry paddy. In this case, appropriate paddy drying technology could play a vital role to strengthen food security by reducing drying loss. Therefore, a study was conducted to investigate the drying loss of paddy both in traditional sun drying and mechanized drying method (BAU-STR dryer) at selected areas of Bangladesh. Popular and mega rice varieties cv. BRRI dhan28 and BRRI dhan49 were used as drying materials to evaluate the performance of BAU-STR dryer with different dryer capacity i.e. 300, 400, 500 and 600 kg of paddy per batch. Drying losses of BAU-STR dryer were examined during Boro and Aman season of 2015 and 2016 whereas drying losses under open sun drying method was measured during Aman season 2017 in the selected areas of Tangail, Mymensingh, Netrokona and Jessore districts of Bangladesh. The results showed that the average drying loss of paddy in BAU-STR dryer was found 0.48% and 0.36% during Boro and Aman seasons, respectively at 2015 and 2016 while sun drying loss at farmer’s field level was found 3.95, 3.24, 2.98 2.41 and 3.04% in Tangail, Mymensingh (Phulpur), Mymensingh (BAU), Netrokona and Jessore districts, respectively. The low cost BAU-STR dryer would be an alternative and effective drying technology to save 1.4 MMT of paddy by reducing 2.7% losses of national production (51.87 MMT) for combating hunger and improving food security in Bangladesh.

Progressive Agriculture, Vol. 30, Suppl. 1: 42-50, 2019
Foot Length as a Predictor of Weight in Children up to Five Years
Authors: Shameem Md , Banu Nazneen Akhter , Bhuiyan ANM Nurul Haque , Islam Ariful
Published: May 2019

Weight measurement is essential for the management of pediatric patients to calculate the dose of the drugs. But it is not possible to move the child to a weighing scale for determination of body weight when the child is in a critical condition. The purpose of this study was to check if foot length correlates with child’s body weight in our situation and to devise a formula for prediction of weight based on foot– length observed. This Cross-sectional study was carried out in the Department of Pediatrics, Sir Salimullah Medical College, Mitford hospital, Dhaka over a period of 12 months between January 2008 and December 2008. A total of 300 children, between 0 day to five years, meeting the predefined eligibility criteria were included in the study. Using the available data, simple linear regression analysis was performed between the dependent variable weight and independent variable foot length. The estimated linear regression line was: Predicted weight (kg) = a+ [b× foot length]. Data were analyzed using correlation coefficient (r) between foot length and children’s weight. In this study correlation between foot length and weight (r) was 0.92(P<0.001) indicating a perfect linear relationship between them. In the present study determination of correlation (r2) was 0.85 meaning that 85% of the variability in weight might be explained by variation in foot length. The estimated linear regression line was: Predicted weight (kg) = - 4.64 + [1.12 X foot length], where- 4.64 was the intercept and 1.12 was the slope of the regression line. Comparison between measured weight and predicted weight revealed that94% of variation between measured weight and predicted weight was within ±2kg. More than half of the cases (58.3%) the above-mentioned variations were within ±1kg.  This study concluded, there was a strong correlation between foot length and weight in children up to five years. The body weight in children from 0 days up to the age of 5 years can be predicted from foot length. Prediction of weight simply by foot-length measurement could be a great help to the health care provider including doctors and health workers for drug dose calculation in critically ill children.

TAJ 2018; 31(2): 39-44
Determination of Mercury Impurities in Protamine Sulfate Medicament by Stripping Voltammetry
Authors: Kim N. O. , Ivanovskaja E. A.
Published: May 2019

Introduction. The article presents data of the quantitative mercury determination in an aqueous solution of the pharmaceutical substance protamine sulfate by stripping voltammetry on graphite electrodes modified with a gold-polymer composition. The existing method to determine the mercury impurity in protamine sulfate according to the European Pharmacopoeia – multistage titration with dithizone – is laborious and does not allow to achieve repeatability.

Aim. Analyzing the content of bioaccumulative mercury impurities in a protamine sulfate solution by stripping voltammetry. Materials and methods. Protamine Sulfate Substance (Manufacturer Alps Pharmaceutical Industry Co.Ltd). Experimental data were obtained on a TA-4 semi-automatic analyzer (OOO NPP Tomianalit, Tomsk) with VALabTx software.

Results and discussion. We adapted the method for mercury determination in water and presented the results of its testing on protamine sulfate solution. The results of testing the electrode operation using the «entered-found» method are given, the results of a single mercury analysis were included in the interval 0, 0038–0,0063 mg/l, which confirms their readiness for work. This interval is registered in the methodology and means the limits of permissible deviations. The limits of detection of mercury on the device are 10-6 –10-10 mol/l. We prepared a solution with concentrations of 10 mg/m from the protamine sulfate substance and measured it on prepared electrodes. The mercury content in the test sample was 0.00034 mg/l. According to the certificate of protamine sulfate, the mercury content should be ≤10 ppm. We studied the effect in changing of accumulation time. The optimal accumulation time was 80 seconds, because under standard conditions, not all mercury concentrates on the electrode surface, and above 80 seconds there is no significant increase in mercury content.

Conclusion. The proposed method for mercury determination in water by stripping voltammetry on graphite electrodes modified with a gold-polymer composition can be adapted to determine bioaccumulative mercury in the pharmaceutical substance protamine sulfate. The findings suggest that this method can be used in quality control of medicines, as an alternative express method for mercury impurities determination to the existing multistage titration method with dithizone.
The Antiviral Activity Study of Complex Drug with Aminocapronic Acid for Prevention of Influenza and ARVI
Authors: Karpova A. S. , Kochkina Y. V. , Kedik S. A.
Published: May 2019

Introduction.Influenza and acute respiratory viral infection (hereinafter – ARVI) are serious diseases that affect up to 500 million people worldwide every year. From 27.3 to 41.2 million people are registered annually in Russia. Thus, the urgent task is to develop new effective drugs aimed at the prevention and treatment of the above diseases. The drug composition for intranasal use based on aminocaproic acid with antiviral activity and a copolymer of N-vinylpyrrolidone and 2-methyl-5-vinylpyridine with a proven immunostimulating action was developed.

Aim.Study of the antiviral activity of the complex drug composition with aminocaproic acid and a copolymer of N-vinylpyrrolidone and 2-methyl-5-vinylpyridine.

Materials and methods.To reach this goal, preparations with different ratios of active substances were used to identify the best efficacy. The study was conducted in comparison with the known drug zanamivir. Antiviral activity was studied against influenza A/Puerto Rico/8/34 (H1N1) virus in white outbred mice upon nasal administration of the test samples. The activity evaluation of the studied drugs was carried out according to the weight values and the death dynamics control and experimental groups of animals. Infectious activity of the virus in the lung tissue of animals was assessed on day 5 after infection by titration on a culture of MDCK cells in a nutrient medium MEM. Virus titer was expressed in logarithm of 50% of the virus experimental infectious dose (lg TCID50) per 200 μl of medium.

Results and discussion.Based on the data obtained during the study of the weight values dynamics and the dynamics of animal death, the drug showed a maximum antiviral activity with a 2:1 ratio of active substances, which is confirmed by the data on viral activity in the lungs of animals, the virus titer was 1.9±0.3 (p=0.616) lg TCID50/0.2 ml.

Conclusion.Antiviral activity of the complex preparation based on aminocaproic acid and N-vinylpyrrolidone and 2-methyl-5-vinylpyridine copolymer was studied, the most effective ratio of active substances was found, it is 2:1. Thus this complex preparation with a ratio of active substances 2:1 reduced the viral load level in the lung tissue of infected mice by more than two times relative to the control group. Therefore, this combination of active substances can be used to develop a promising drug for nasal use as treatment and prevention of influenza and ARVI.
Soft Medical Form with Nanoparticles to Stop Bleeding: Substantiation of Composition and Technology of Obtaining
Authors: Barsukova Yu. N. , Melnikova O. A.
Published: May 2019

Introduction. Due to the growth of general surgical diseases, the treatment and cessation of bleeding is an important problem of medicine and pharmacy. The existing range of hemostatics does not always meet the needs of medical practice and does not provide a wide choice of drugs. Given the great need for drugs to stop bleeding, their development is an urgent task for the modern pharmaceutical industry. One of the promising areas of the creation of dosage forms is the development of hemostatic ointment. Soft dosage forms with optimal rheological characteristics are characterized by a good degree of spreading and easy extrusion of tubes. In the present work, the composition and technology of hemostatic ointment with a nanocomponent was proposed.

Aim. Justification of the optimal composition by studying the rheological parameters and the development of technology for producing a soft dosage form with nanoparticles to stop bleeding.

Materials and methods. The pharmaceutical substance was aminocaproic acid (FS.2.1.0001.15), iron III chloride (GOST 4147-74), iron oxide nanoparticles (GOST R 57909-2017). The nanoparticles used in this work were obtained by a levitation jet method in a carrier gas medium. The work used technological, physical and chemical research methods. The method of rotational viscometry on the instrument Haake VT550 viscometer is described methodically in detail. Statistical processing of the results was carried out according to the GF XIV methods using standard computer programs.

Results and discussion. As a result of the study, it was found that the viscosity of the ointment samples studied gradually decreased with an increase in shear rate, but was non-linear. This dependence is characteristic of systems with a plastic type of flow and characterizes the samples under study as a structured dispersed system. It was also found that the samples of the soft dosage form had thixotropic properties. This in turn serves as an indicator of good lubrication and extrusion of tubes.

Conclusion. A production technology has been proposed and a technological scheme for the production of a hemostatic soft dosage form with nanoparticles has been designed.
Research and Development of the Composition and Technology Receving of Granules of Omeprazol in the Fluid Bed Apparatus
Authors: Mazova N. V. , Marchenko A. L. , Smehova I. E.
Published: May 2019

Introduction. In this research is devoted to questions of development of structure and technology of granules of an omeprazole. It is established that the most optimal dosage form for medicines of inhibitors of a proton pump is considered to be the tablet with a multiple-unit pellets system (microparticles). In this case of the production of these medicines in the microgranules of a particle are covered with several protective covers. For development of microgranules of an omeprazole is offered the technology of lamination in the fluid bed apparatus.

Aim. To receive in the fluid bed apparatus of the microgranules of an omeprazole covered with the enteric cover.

Materials and methods. To solve this problem technical characteristics on the granulates of an omeprazole received at various operating modes of the fluid bed apparatus are defined such as form of granules, fractional structure and bulk density are determined by the methods described by the State Pharmacopeia of the XIII edition.

Results and discussion. As a result of a research the choice of polymers for layered deposition in the granulation process of a substance of omeprazole is substantiated. Produced selection of enteric polymer of various firms of producers is made for providing a necessary profile of release of an omeprazole in a human body. A copolymer of methacrylic acid – Kollicoat MAE 100 P is chosen. Special attention is paid to receiving the enteric granules of an omeprazole of the correct spherical form with minimum roughness and the improved flowability for further tabletting. For the purpose of receiving granules of an omeprazole of a spherical form selection of an optimum operating mode of the device of a fluid bed apparatus is made for implementation of process of applying the enteric polymer. Following the results of experiments the dependence of quality of fractional structure and appearance of granules of an omeprazole on temperature, pressure and feed rate of polymer is defined. Besides, it is established that the uniformity of application and thickness of a layer of the applied enteric polymer on granules of an omeprazole depend not only on the polymer feed rate, but also on the size of drops of the feed solution.

Conclusion. It is established that the quality of the granules of an omeprazole received the enteric polymer was affected by such factors of technological parameters of the fluid bed apparatus as: temperature of the entering air in the apparatus, the air pressure upon a nozzle, air pressure upon a gas-distributing grid of the apparatus, speed of the given polymer, a lot of loading of granules, air temperature of a layer of granules, duration of drying of granules upon termination of process of application of the enteric polymer.
Features of Microelements Express-determination in Medicinal and Nonoficinal Plants by X-Ray-Fluorescence Analysis
Authors: Makarova M. P. , Syroeshkin A. V. , Maksimova T. V. , Matveeva I. S. , Pleteneva T. V.
Published: May 2019

Introduction. The chemical composition of plants depends on the elemental composition of the habitat, and also reflects the species and individual characteristics of the plant. Before using any plant for medicinal purposes, it is also necessary to collect as much information as possible about the elemental composition of the feedstock.

Aim. Consequently, it became possible to create a method for the rapid determination of trace elements in plants using the X-Ray fluorescent method.

Materials and methods. In accordance with the international intercalibration standard in the IAEA system (IAEA-433), an international standard sample NIST SRM 2976, certified by the National Institute of Standards and Technology (USA), was used to provide external quality control (QA/QC) of laboratory elemental analysis. For Zn the results of plant raw powder materials analysis by XRF (express analysis) were compared with AAS by electrothermal atomization and Zeeman background correction after microwave acid mineralizationof biomaterials. To ensure the reproducibility of the results of XRF-express analysis, it is absolutely necessary to carry out mild drying and dispersion of the plant material.

Results and discussion. The results of X-ray fluorescence (XRF) analysis of the elemental composition of the fruits (fructus Anethi graveolens L.), the seeds (semina Cucurbitae pepo L., semina Menthae arvensis L., semina Cucumis sativa L., semina Kalanchoës daigremontianae) and leaves (folia Callisiae fragrantis L.) of medicinal and nonoficinal plants are presented in the article. The methods of XRF and AAS analysis have been developed for the technology of essential micoelements enrichment in of Callisiae fragrantis control leaves at different ratios of hydrogen isotopologues (D/H) in the water.

Conclusion. For example, zinc(II) has demonstrated the ability to create modified plants with high content of essential microelement, up to 1.4 mg /g dry weight.
HPLC-Analysis of Phenolic Complex in Pectoral Species № 4 and it’s Dry Extract
Authors: Skibina A. A. , Bokov D. O. , Gravel I. V. , Ermakova V. A. , Samylina I. A.
Published: May 2019

Introduction. There is steady upward trend in demand for herbal formulation necessitates the expansion of their range. Recent studies have shown that one of the promising research direction is the development of herbal collection based water-soluble dry extracts. Pectoral species № 4 is one of the most popular among multi-component herbal preparations on the Russian pharmaceutical market. Experimental samples of a dry extract were obtained on the collection basis. According to literature, phenolic compounds predominate both in individual components and pectoral species № 4. Therefore, the end-to-end standardization of the collection and its dry extract by the content of the substances seems to be relevant.

Aim. The present study was performed to examine the dry extract phenolic compounds composition, as well as, to search for marker compounds for the end-to-end standardization of pectoral species № 4 and dosage forms based on it.

Materials and methods. The composition and content of phenolic complex were studied by HPLC with UV detection in pectoral species № 4 and its dry extract. Detection was performed at wavelengths of 350, 300, 270, 210 nm. The quantitative content (%) of the identified compounds was determined by an external standard method.

Results and discussion. HPLC-analysis revealed 58 compounds in pectoral species № 4 and 34 in the extract. Rutin, arbutin, liquraside, liquiritin, quercetin, chlorogenic, caffeic and gallic acid have been identified in all study objects; their quantitative content varied within a range of 0,001−0,910%.

Conclusion. Arbutin, rutin and chlorogenic acid have been proposed as marker compounds.
ORYANTALİSTLERİN ŞAM EMEVİYYE CÂMİİ İLE DİYARBAKIR ULU CÂMİİ HAKKINDAKİ İDDİALARI VE BU İDDİALARA K.A.C. CRESWELL’İN CEVAPLARI ÜZERİNE YENİDEN DÜŞÜNME
Authors: AYKAÇ Fettah , DOĞANAY Aziz
Published: May 2019

Son
asırlarda, oryantalist yaklaşıma sahip Avrupalı araştırmacıların çoğu ‘Müslümanların
erken devirde Hıristiyanlardan fetih yoluyla aldığı bazı şehirlerdeki, halen
transeptli plana sahip, önemli cami yapılarının önceden kilise oldukları ve
sonradan tamamen camiye tahvil edilinceye kadar Hıristiyanlarla paylaşılarak ortak
kullanıldıkları’ türden iddiaları yayınlarında sürekli tekrar ederek gündemde
tutmuşlardır. Bu iddialarına delil olarak da ‘Şam Emeviyye Câmii’nin önceden
Temenos yapısı olarak bilinen Roma/Pagan Jüpiter Tapınağının avlusundaki
Vaftizci Yahya (St. John The Baptist) Kilisesi olduğu’ şeklinde erken devir
Müslüman müelliflerin kitaplarında da yazılı olduğu söylenen rivayetleri
göstermişlerdir[1].

Bu
iddia daha sonra Diyarbakır Ulucâmii ilavesiyle C.Warzinger ve K.
Wulzinger tarafından 1921’de yayınlanan ‘Damascus I’ isimli kitapta
ciddi bir şekilde tekrar dile getirilerek, gerçeğe en yakın ihtimal olarak
yerleştirilmeye çalışılmıştır. Gerçekte tarihî bir belgesi olmayan bu görüşler
1940’ların sonunda Avrupalı yayınlardan yapılmış olan özet tercümeler yoluyla
Türkçe literatüre de girip ‘alternatifi olmayan/gerçeğe en yakın rivayetler’
olarak yerleşmiş ve sonraki yayınlarda tekrar edilmiştir. İngiliz araştırmacı K.A.C.
Creswell (1876-1974), dünya çapında meşhur olan 1932 ve1969 tarihli ‘Erken İslâm
Mimarisi’ isimli kitaplarında bunları ele alıp tutarsızlıklarını tarihî ve
mimarî delillerle ortaya koymuştur. Ancak, Creswell’in cevapları ve bu konuda
yazdığı çok önemli bilgiler, söz konusu iddiaların alternatifi olarak henüz
Türkçe yayınlara girmemiştir.

Bu
makalede, oryantalistlerin propagandasını yaptığı tutarsız iddialarla, bunlara alternatif
olarak K.A.C. Creswell’in cevapları ve aktardığı bazı önemli bilgiler, sanat tarihi
ve İslâm mimarisi eğitimi müzakerelerinde, yardımcı kaynaklarında ve bundan
sonra yapılacak yayınlarda yerini alması ümidiyle araştırmacıların dikkatine
sunulmuştur.
‘’Summer Doesn’t Come with a Single Rose’’ : A Qualitative Research of Turkish Mothers’ Social Support Systems who Have a Chıld with ASD
Authors: Değirmenci Gizem Yağmur
Published: May 2019

Being a mother is defined as a serious life event in which women often
experience physical, psychological and sociological changes. Parenting a child
diagnosed with autism can be associated with a high risk of presenting mental
health problems such as anxiety and depression. Therefore, researchers,
educators or professionals have focused on family members, as well as ASD
individuals. Involvement of a child with special needs in the family can often
bring stressful and challenging experiences. The purpose of this study is
twofold; first, to explore their perspectives on children and social support
systems of women with children who have autism spectrum disorder (ASD) and
second, to unfold their life experiences. The
study was structured using qualitative research method. Qualitative
interviews were conducted with mothers of children diagnosed with ASD in
Ankara, Turkey.  Interviews were
conducted with 11 middle age, unemployed Turkish mothers.  Data
was collected through semi-structured interviews and content analysis was used.
The results are interpreted in two main themes (perspectives of mothers on their
children and social support). According
to the research findings, women mostly don’t have social support and they
gradually lose connection to their husbands and other family members or peers.
Finally, the findings obtained from the study were discussed in the light of
the relevant literature. 
Rehberlik Öğretmenlerinin Okul Sosyal Hizmetine İhtiyaç Duydukları Sorun Alanlarının Belirlenmesi
Authors: Kuli Güliz , Yıldırım Şeyda
Published: May 2019

Bu
araştırma ile rehberlik öğretmenlerinin okul sosyal hizmetine ihtiyaç
duydukları sorun alanlarının belirlenmesi amaçlanmıştır. Araştırma, İzmir’in
yoğun nüfuslu beş bölgesinden (Bornova, Karabağlar, Konak, Karşıyaka, Buca)
seçilen 100 rehberlik öğretmeni ile gerçekleştirilen nicel bir çalışmadır.
Katılımcıların temel sosyo-demografik bilgilerinin yanı sıra, okulda
karşılaştıkları sorunlarla ve okul sosyal hizmetine yönelik düşünce ve
ihtiyaçlarını öğrenmeye yönelik sorulara yer verilen anket formu ile veriler
toplanmıştır. Araştırmanın verileri yüz yüze görüşme yöntemi ile elde
edilmiş,  veri işleme ve çözümleme
aşamasında SPSS 15.0 programından yararlanılmıştır. Araştırmanın bulgularına
göre rehberlik öğretmenlerinin çoğunlukla sosyal hizmet mesleği hakkında bilgi
sahibi olduğu ve okul sorunlarının çözümüne sosyal hizmet uzmanlarının katkı
sağlayacağını düşündükleri sonucuna ulaşılmıştır. Rehberlik öğretmenlerin
çoğunluğunun okul ortamlarında başarısızlık, 
saldırganlık, ihmal ve istismar, ev içi şiddet, madde bağımlılığı ve
suça sürüklenme gibi pek çok sorunla karşılaştığı ve bu sorunların çözümü için
sosyal hizmet uzmanına ihtiyaç duyduğu görülmüştür. Bundan dolayı okul sosyal
hizmeti uygulamasının hayata geçirilmesi ve okul sosyal hizmeti alanının tanıtılmasına
yönelik çalışmaların yapılması oldukça önemli görülmektedir. 
Kök Hücre Nakli Sürecinde Aile Merkezli Onkolojik Sosyal Hizmet Uygulaması
Authors: Sever Melih , İl Sunay
Published: May 2019

Lösemi ve
lenfoma gibi hematolojik kanser türlerinde uygulanan kök hücre nakli tedavisi
yetişkin hasta birey ve ailesini fiziksel sorunlarla birlikte psiko-sosyal sorunlarla
da oldukça örselemektedir. Türkçe literatürde kök hücre nakli sürecinde sosyal
hizmet uzmanı rollerini inceleyen çalışmaların azlığı ve onkoloji
hastanelerinde psiko-sosyal hizmetlere duyulan ihtiyaç bu çalışmanın sorununu
oluşturmaktadır. Hasta bireyin aileden izole olmasını, aile içindeki rollerin
değişimini ve yaşamsal rutinin belirsiz bir süre boyunca bozulmasını öngören bu
hastalık ve tedavi süresince sosyal hizmet birimlerinin hasta ya da birey odaklı
değil aile merkezli çalışması gerektiği tartışılmıştır. Buna göre kök hücre
nakli öncesinde teşhis aşamasında devreye girmesi gereken onkolojik sosyal
hizmet birimlerinin, tedavi sırasında, tedavi sonrasında farklı müdahaleler ve
rollerde bulunması gerekmektedir. Bu çalışmada onkoloji hastaneleri başta olmak
üzere hastanelerde onkolojik sosyal hizmet birimlerinin kurulması, kanser
hastalarına ve ailelerine aile merkezli ve aile sisteminin dengesini gözeten hizmet
verilmesi, ailelere çocukların ve hastanın bakımı, finansal sorunlar gibi
konularda danışmanlık verilmesi, onkolojik sosyal hizmet birimlerinin
çocukların dışsallaştırılmamasına önem göstermesi ve çocukları ebeveynlerinin
sağlık durumu hakkında bilgilendirmesi gerektiği belirtilmiştir. 
Еволюція теорії ціноутворення та їх вплив на формування ціни на продукцію військового призначення
Authors: Tkach Ivan , Malanchuk Maryna
Published: May 2019

В статті проведено аналіз розвитку теорії цін і ціноутворення, які розглядалися в теорії трудової вартості, теорії граничної корисності та завершуючи сучасними напрямами неокласичного синтезу, що становлять теоретичну основу сучасних досліджень ринкового господарства. Пізнання економічної природи ціни відзначається за наступними етапними: кількісна теорія грошей, яка отримала широке поширення у вигляді “рівняння обміну” (MV = PQ); теорія трудової вартості визначає ціну як грошовий вираз мінової вартості товару; теорія граничної корисності де ціна представляється у вигляді оцінки граничної корисності даного блага, ціна є грошовий вираз кінцевої або граничної корисності економічного блага. Дані теорії не враховують специфіки ціноутворення на продукцію військового призначення, адже дана продукція має специфічні характеристики, а саме: єдиний покупець це держава, в більшості випадків присутня монополія на даний вид продукції тощо. Тому виникає необхідність розробки методології ціноутворення на продукцію військового призначення.
Концепція дослідження проблем забезпечення воєнно-економічної безпеки держави
Authors: Ткач Іван
Published: May 2019

В статті проведеній аналіз економічних систем суспільства. Розроблено концептуальні засади дослідження сучасної економічної системи суспільства. Дана концепція дає змогу із застосуванням системного підходу в науковому пізнанні виділити певні логічні ланцюжки взаємодії складових суспільного устрою у відповідній субординації. Встановлено, що інтегральним результатом економічної діяльності економічної системи суспільства є стан добробуту громадян, в кінцевому вимірі – кожної людини, як головного чинника економічного розвитку. На підставі даної концепції розроблено Концептуальні засади дослідження проблем національної безпеки держави. Запропоновані концептуальні засади розвивають, розкривають і розширюють потенційні можливості методології економічних систем і є першим прикладом застосування ідей цієї методології для дослідження прикладних, практично-значимих для держави проблем, таких як національна безпека держави. Розвиваючи розглянуті концептуальні засади запропоновано концепцію дослідження воєнно-економічної безпеки держави з позиції економічної детермінанти. Запропоновані вперше підходи до побудови концепцій дослідження проблем сучасної економічної системи суспільства, національної безпеки держави і забезпечення воєнно-економічної безпеки держави з позиції економічної детермінанти, які продовжують пошуки у науковому і практичному економічному середовищі у напрямку уточнення, переосмислення і оптимізації категорії “Економічна система суспільства” і її прикладного застосування для забезпечення національної безпеки держави.
Обгрунтування доцільності розробки індикаторів внутрішнього контролю в Міністерстві оборони України та Збройних силах України
Authors: Loishyn Anatolii , Shpytal Oleksandr , Tkach Ivan
Published: May 2019

Стаття може викликати цікавість у представників аудиторської служби, учасників внутрішнього контролю та керівників усіх рівнів у системі Міністерства оборони України та Збройних Сил України. В процесі дослідження проводиться частковий аналіз керівних документів, що регламентують питання організації та функціонування систем внутрішнього аудиту та внутрішнього контролю в оборонному відомстві. Визначено взаємозв’язок вказаних систем. Встановлено, що внутрішній аудит є елементом вітчизняної системи державного внутрішнього фінансового контролю, яка розглядається як трирівнева модель. Проведений у статті аналіз доводить, що аудит не бере участі у прийнятті управлінських рішень щодо управління фінансовими, матеріальними та іншими ресурсами і не несе відповідальності за внутрішній контроль, а здійснює оцінку ефективності функціонування систем внутрішнього контролю, запроваджених керівниками організацій. У статті підкреслюється важливість застосування в оборонному відомстві моделі “Трьох ліній оборони”. Незалежна функція внутрішнього аудиту за допомогою ризик-орієнтованого підходу до її виконання має забезпечити достатню впевненість (гарантії) для вищого керівництва. В процесі дослідження проведено не лише аналіз нормативно-правових актів, які регламентують його діяльність, а й аналіз результативних показників діяльності підрозділів внутрішнього аудиту. Доводиться висока ефективність та результативність діяльності підрозділів внутрішнього аудиту. У статті проаналізовано підходи до організації та функціонування внутрішнього контролю в оборонному відомстві. Визначено основні елементи внутрішнього контролю та його учасників. Встановлено відсутність у учасників внутрішнього контролю відповідних компетентностей, здатності до розуміння процесів, що можуть призвести до порушення функціонування системи суб’єкту внутрішнього контролю якими володіють представники аудиторської служби. Вироблено рішення стосовно розроблення певних рекомендацій учасникам внутрішнього контролю у вигляді розробки певної системи індикаторів, які можуть сигналізувати та попереджувати про збій у функціонуванні системи стосовно управління фінансовими, матеріальними та іншими ресурсами.