bluuebunny/crossref_metadata_2025 huggingface dataset:
Navigating the Agricultural Landscape
Authors: Sidhu Gaurav
Published: May 2024

Abstract: In today’s world agricultural landscape, technological progress has become essential for improving productivity, sustainability, and profitability. This paper investigates Farm Tech Central, an innovative platform that sits at the intersection of agricultural technology and information sharing. Through a thorough examination, this paper clarifies the crucial role played by Farm Tech Central in enabling access to state-of-the-art agricultural technologies, research findings, and best practices. Acting as a central hub for farmers, agronomists, researchers, and industry stakeholders, Farm Tech Central provides users with valuable resources and tools to enhance farm operations, manage risks, and take advantage of emerging opportunities. Utilizing case studies, data analysis, and expert opinions, this paper delves into how Farm Tech Central is transforming agriculture by promoting modernization, encouraging sustainable practices, and fostering innovation. As the agricultural sector continues its journey towards digitalization and technological integration, Farm Tech Central emerges as a leading platform for collaboration, knowledge sharing, and technological progress, poised to usher in a new era of agricultural excellence
Elevating Forestry Prediction: A Study on Machine Learning Model for Plantations Survival Rate Analysis
Authors: Rathore Akshaya
Published: May 2024

Abstract: This paper details the development and preliminary findings of a machine learning model designed to predict the survival rate of plantations. Drawing data from official sources, various vegetation indices were used as features for the predictive model. Initial results show potential, despite certain limitations, suggesting avenues for further enhancement and application.
Building Energy Optimization using BIM: A Study on Institutional Building
Authors: Yuvaraj M. S. , Nurulla Shaik , Purushotham D V , Krishna A Yaswanth , Sai V Krishna , Babu B Lokesh , Azaruddin P
Published: May 2024

Abstract: In many facets of the construction industry, including energy management to encourage the development of green buildings, Building Information Modelling (BIM) is one of the contemporary data information platforms and management technologies that is widely employed. The goal of this study was to optimize an institutional building's energy consumption by analyzing and evaluating its energy performance using BIM-provided capabilities. The Civil Engineering block of Sree Vidyanikethan Engineering College in Tirupati, was taken into consideration for the investigation. The 2D blueprint was obtained from the engineering department and BIM technologies were used to create the necessary building model. The Green Building Studio (GBS) tool and Autodesk Insight 360 were utilized to conduct an energy analysis and derive the energy usage figures. The structural elements that are contributing to the high energy demand, such as the area between windows and walls, the width of the chajja relative to the height of the window, etc., were identified, and the BIM model underwent the required alterations to optimize the energy consumption. Comparing the data obtained in the two aspects, it was found that there was a 30% reduction in energy costs and a roughly 29.76% drop in energy use.
Enhancement Network Security Features Through Intrusion Detection Systems
Authors: Kashyap Ramgopal
Published: May 2024

Abstract: In pursuit of its objectives, the project "Enhancement Network Security features through Intrusion Detection Systems" undertakes a comprehensive exploration of the intricacies surrounding network security, delving into the nuances of intrusion detection methodologies. By dissecting the mechanisms behind both anomaly- and signature-based IDS, the initiative aims not only to implement these systems but also to grasp their underlying principles deeply. Through rigorous experimentation and analysis, the project endeavours to uncover the strengths and limitations of each approach, thereby paving the way for the development of a hybrid system that leverages the best of both worlds. This meticulous approach ensures that the resulting IDS is not only robust but also finely tuned to adapt to the ever-evolving landscape of cyber threats. Furthermore, the integration of machine learning techniques represents a pivotal advancement in the realm of intrusion detection. By harnessing the power of algorithms capable of autonomously learning from data, the IDS transcends static rule-based detection methods, ushering in a new era of adaptive security measures. Through continuous training on vast datasets comprising diverse threat scenarios, the machine learning-enabled IDS hones its ability to discern subtle patterns indicative of malicious activity, thus bolstering its efficacy in safeguarding network assets. Moreover, the implementation of machine learning algorithms fosters a proactive stance against emerging threats, enabling the system to anticipate and mitigate potential breaches before they materialize into fullfledged attacks. This proactive approach not only enhances the overall security posture of organizations but also instils confidence in their ability to stay ahead of the curve in an increasingly hostile digital landscape. The project's goal is to provide companies with a stronger protection against cyberattacks by guaranteeing the availability, confidentiality, and integrity of their networked systems.
Biochar Enriched Concrete for Carbon Sequestration
Authors: Tirpude Vikram R.
Published: May 2024

Abstract: In upcoming years , a lot of construction is going to happen leading to more cement consumption and more GHG’s emissions by default as an embodied carbon. Reduction of cement consumption is possible by partially repacing it with biochar which is a by-product of pyrolysis of biomass or adding it as an additive in cement mortar and concrete for carbon sequestration. Biochar is effective in carbon sequestration activity and results in high water and carbon dioxide holding capacity. Increase in biochar lead to increase in carbon sequestration . As pozzolanic activity lead to strength gaining characteristics and durability of concrete, this study focusses on investigating pozzolanic activity of biochar. Biomass considered in this study were walnut shells and pretreatment was done with 0.1 N HCl and and pozzolanic activity is checked by chapelle test by observing Ca(OH)2 fixation during the titration. It was observed that increase in temperature or Normality of HCl in pretreatment does not enhance pozzolanic activity of biochar . Hence pretreatment with 0.1 N HCl at room temperature for an hour is sufficient to enhance the pozzolanic activity of biochar with much high carbon dioxide sorption as compared to usual concrete without compromising with the strength of concrete. This study reclaims the potential use of biochar in concrete is reliable for carbon sequestration.
Determinan Penyerapan Tenaga Kerja Di Provinsi Jawa Timur
Authors: Silfiana Evie
Published: May 2024

Problems that have not been resolved so far in Indonesia are related to employment. The increasing number of people looking for work is not proportional to the number of available jobs. This study aims to analyze the determinants of employment in East Java Province by using three independent variables, namely domestic investment, provincial minimum wage and number of industries. This study uses time series data with a period of 31 years, namely from 1990 to 2020. The method used is multiple linear regression. The results of the study show that PMDN investment, the provincial minimum wage and the number of industries have a significant influence on employment in East Java Province.
Analisis Pengaruh Indeks Kesehatan dan Indeks Pendidikan, Angkatan Kerja dan Jumlah Penduduk Terhadap IPM di Provinsi Jawa Timur Tahun 2015-2021
Authors: Aryanti Elsa Nova
Published: May 2024

This study aims to analyze the effect of the human development index which consists of the education and health index variables, the labor force, and the population in East Java Province in 2015 – 2021. The data used in this study uses panel data with time series for the last seven years from 2015 – 2021 with thirty eight regencies/cities in East Java Province. The best regression results using a random effect model. where the results show that the variable level of education, health and workforce have a positive and significant effect, and the variable population size has a negative and significant effect on the HDI of districts/cities in East Java province.
Efektivitas Dan Kontribusi Sumber-Sumber Pendapatan Asli Daerah Di Satuan Wilayah Pengembangan Malang Raya
Authors: Cantika Roseida , Riyanto Wahyu Hidayat
Published: May 2024

The purpose of this study was to find out how much the level of effectiveness and contribution obtained from the sources of Regional Original Revenue (PAD). This research was conducted in the Greater Malang Development Area Unit (SWP), which consists of Malang Regency, Malang City, and Batu City. The data used is secondary data, namely data taken from official data from the Directorate General of Fiscal Balance (DJPK Ministry of Finance). The data used includes target data and realization of PAD, regional taxes, regional levies, separated regional wealth management results, and other legitimate PAD. The research method used is the ratio of effectiveness and contribution of PAD sources to PAD in the three regions used. The results show that the average level of effectiveness of PAD in Malang Regency, Malang City, and Batu City in 2021 is 103%, 92%, and 93%, respectively, which are classified as effective criteria. In this way it can be concluded that the performance of the government in SWP Malang Raya (Malang Regency, Malang City, and Batu City) has been able to realize the regional PAD effectively and exceed the targets set.
Analisis Kausalitas Antara Korupsi, Investasi, Pengangguran dan Pertumbuhan Ekonomi
Authors: Haldi Muhammad
Published: May 2024

This study analyzes the causality and short-term and long-term relationships between corruption, investment, unemployment, and per capita economic growth in twenty-two Asia-Pacific countries from 2012 to 2020. This study uses the Granger causality approach and the Vector Error Correction Model to answer the problem in this study. The empirical results show that corruption and per capita economic growth has a two-way causality, and the unemployment rate and per capita economic growth only have a one-way causality. On the other hand, the rest have no causal relationship. In the short term, corruption does not significantly affect per capita economic growth and unemployment. However, significant and negative in influencing the level of investment. Meanwhile, in the long term, corruption significantly and negatively affects economic growth per capita. The level of investment and unemployment has a significant and positive effect on economic growth per capita. Therefore, corruption is an obstacle to economic growth and not a "lubricant."
 
Studi ini menganalisis kausalitas dan hubungan jangka pendek dan jangka panjang antara korupsi, investasi, pengangguran, dan pertumbuhan ekonomi per kapita di dua puluh dua negara Asia-Pasifik dari tahun 2012 hingga 2020. Studi ini menggunakan pendekatan kausalitas Granger dan Vector Error Correction Model untuk menjawab permasalahan dalam penelitian ini. Hasil empiris menunjukkan bahwa korupsi dan pertumbuhan ekonomi per kapita memiliki kausalitas dua arah, sedangkan tingkat pengangguran dan pertumbuhan ekonomi per kapita hanya memiliki kausalitas satu arah. Di sisi lain, sisanya tidak memiliki hubungan sebab akibat. Dalam jangka pendek, korupsi tidak secara signifikan mempengaruhi pertumbuhan ekonomi per kapita dan pengangguran. Namun, signifikan dan negatif dalam mempengaruhi tingkat investasi. Sementara itu, dalam jangka panjang, korupsi secara signifikan dan negatif mempengaruhi pertumbuhan ekonomi per kapita. Tingkat investasi dan pengangguran berpengaruh signifikan dan positif terhadap pertumbuhan ekonomi per kapita. Oleh karena itu, korupsi merupakan penghambat pertumbuhan ekonomi dan bukan "pelumas".
Analisis Investasi dan Peran Teknologi Informasi Terhadap Pembangunan Ekonomi Inklusif di Jawa Timur
Authors: Prawesti Rivalda Putri
Published: May 2024

The purpose of this study is to determine the effect of investment and information technology on inclusive economic development in East Java. This research method is a quantitative research method by taking statistical data from BPS and Bappenas. Data collection used documentation techniques, namely collecting, recording and reviewing documents regarding data from the Central Statistics Agency and the National Development Planning Agency (Bappenas) for 2016-2021 which were taken directly from the BPS and Bappenas websites. Normality test, multiple linear regression analysis and regression coefficient significance test were performed as data analysis techniques. The results of the partial model test show that investment has a positive and significant effect on inclusive economic development. Meanwhile, information technology has a positive and significant effect on inclusive economic development. Simultaneous testing of the model shows that investment and information technology have a significant effect on inclusive economic development.
 
Tujuan dari penelitian ini adalah untuk mengetahui pengaruh investasi dan teknologi informasi terhadap pembangunan ekonomi inklusif di Jawa Timur. Metode penelitian ini adalah metode penelitian kuantitatif dengan pengambilan data statistik yang berasal dari BPS dan Bappenas. Pengambilan data menggunakan teknik dokumentasi yaitu mengumpulkan, mencatat dan mengkaji dokumen-dokumen tentang data Badan Pusat Statistik dan Badan Perencanaan Pembangunan Nasional (Bappenas) tahun 2016-2021 yang diambil secara langsung dari web BPS dan Bappenas. Uji Normalitas, Analisis regresi linier berganda dan uji signifikansi koefisien regresi dilakukan sebagai teknik analisis data. Hasil uji model parsial menunjukkan bahwa investasi berpengaruh positif dan signifkan terhadap pembangunan ekonomi inklusif. Sementara itu, teknologi informasi berpengaruh positif dan signifikan terhadap pembangunan ekonomi inklusif. Pengujian model secara simultan menunjukkan bahwa investasi dan teknologi informasi berpengaruh secara signifikan terhadap pembangunan ekonomi inklusif.
Analisis Pengaruh Modal, Lama Jam Kerja, dan Jumlah Barang Terjual Terhadap Pendapatan Pasca Revitalisasi Pasar Jatirogo
Authors: Suryani Dina Feri
Published: May 2024

Income is an important component of trading activites especially in traditional markets. In this study aims to see how much the impact of capital, length of working hours, and sales volume on the traders income is. This quantitative research types uses cross section of 30 traders in 2022 with the Ordinary Least Square (OLS) technique in the multiple linear regeression model. The result of the research showed that capital, length of working hours, and sales volume had a positive and significant impact on traders income in the Jatirogo market.
 
Pendapatan merupakan suatu komponen yang penting dalam kegiatan usaha berdagang di pasar tradisional. Pada penelitian ini bertujuan untuk melihat seberapa besar pengaruh modal, lama jam kerja, dan jumlah barang terjual terhadap pendapatan pedagang. Objek penelitiannya adalah pedagang di Pasar Jatirogo Kabupaten Tuban. Jenis penelitian yang digunakan adalah penelitian kuantitatif dengan data cross section berupa 30 orang pedagang pada tahun 2022 dan teknik Ordinary Least Square (OLS) pada mode regresi linier berganda. Hasil penelitian menunjukkan bahwa variabel modal, lama jam kerja, dan jumlah barang terjual berpengaruh positif dan signifikan terhadap pendapatan pedagang di Pasar Jatirogo.
Evaluasi Program BLT Dana Desa Terhadap Masyarakat Miskin di Desa Rejoagung Kecamatan Ngoro Kabupaten Jombang
Authors: Inayah Winanda Fadhilla
Published: May 2024

This research aims to analyze the influence of education, income and number of family dependents on the amount of direct cash assistance in Rejoagung Village. This research uses primary data and secondary data with quantitative analysis assisted by statistical tools, namely multiple linear regression analysis. The results of this research show that direct cash assistance in Rejoagung Village is working quite well. Income influences direct cash assistance, while education and number of family dependents do not significantly influence direct cash assistance.
 
Penelitian ini bertujuan menganalisa pengaruh pendidikan, pendapatan dan jumlah tanggungan keluarga terhadap besarnya bantuan langsung tunai di Desa Rejoagung. Penelitian ini menggunakan data primer dan data sekunder dengan analisis kuantitatif yang dibantu dengan alat bantu statistic, yakni analisis regresi regresi linier berganda. Hasil penelitian ini menunjukkan bahwa bantuan langsung tunai di Desa Rejoagung berjalan cukup baik. Pendapatan mempengaruhi bantuan langsung tunai, sedangkan pendidikan dan jumlah tanggungan keluarga tidak cukup mempengaruhi bantuan langsung tunai.
Determinan Pertumbuhan Ekonomi Indonesia Tahun 1991-2022
Authors: Kaimuddin Abdul
Published: May 2024

The study aims to examine the effect of FDI, inflation, exports, and unemployment on Indonesia’s economic growth from 1991 to 2022. It used the Error Correction Model (ECM). The results showed that FDI, inflation, and exports significantly affect Indonesia's economic growth in the long run. In contrast, FDI and inflation significantly affect Indonesia’s economic growth in the short run.
Analisis Penyerapan Tenaga Kerja Dengan Inflasi Sebagai Variabel Moderasi Di Negara ASEAN 4
Authors: Suwito Dito Ardian
Published: May 2024

This research aims to analyze the influence of investment and economic growth on labor absorption and the impact of inflation in moderating investment and economic growth on labor absorption. This study uses quantitative methods and panel data in its calculations and includes data on ASEAN, which has the most significant level of industrialization. Using panel data and cross-section for 12 years and time series in 4 ASEAN countries, calculations using multiple linear regression analysis. The findings of this study show that in advanced industrial countries in ASEAN Region 4, economic growth has a positive and significant influence on labor absorption. In contrast, investment has a negative and significant influence on labor absorption. Inflation can also strengthen investment toward labor absorption with positive and important results, but inflation cannot moderate economic growth toward labor absorption with negative and insignificant results.
Pengaruh Ekspor Terhadap Pertumbuhan Ekonomi Indonesia Dengan Angkatan Kerja Sebagai Variabel Moderasi Tahun 1993-2022
Authors: Apriliani Angela Putri
Published: May 2024

Economic growth is a long-term problem for a country's economy, and it aims to achieve a better condition over a certain period. It can also be related to an increase in the production capacity of an economy. This research aims to see whether the workforce can strengthen the influence of exports on economic growth. Research Method The research uses time series data from the World Bank from 1993-2022. The test results show that exports and the workforce positively affect economic growth. Meanwhile, the MRA test results show that the workforce cannot moderate the influence of exports on economic growth.
Evaluation of Some Hormones Total Antioxidant Capacity and Malondialdehyde Levels in Polycystic Ovarian Syndrome Women attending the gynecology Clinic at Nnewi
Authors: Ihim Augustine Chinedu , Onyenekwe Charles Chinedum , Eze Nkiruka Nwamaka , Obi Patrick Chinedu , Osakue Nosakhare , Awalu Joseph Chimezie , Ikwelle Tochukwu Anthony
Published: May 2024

Polycystic ovarian syndrome (PCOS), marked by oxidative stress and hormonal imbalances, causes infertility, insulin resistance, and diverse health problems. It not only affects physical health but also can strain marriages and lead to divorce, posing a notable societal issue. The levels of hormones (Estradiol (E2), Dihydroepiandrosterone sulfate (DHEA), luteinizing hormone (LH), follicle-stimulating hormone (FSH), progesterone (PROG) Testosterone (TEST)), total antioxidant capacity (TAC) and Malondialdehyde (MDA) in PCOS Women attending the gynecology Clinic at Nnewi were investigated. This cross-sectional study had 45 participants with PCOS as a test group and 45 participants without PCOS as the control group between the ages of 18-50 recruited. All the biochemical parameters were determined by enzyme-linked immunoassay technique. Data was expressed as Mean ± standard deviation. The differences in parameters studied between the PCOS group (test) and the control group were evaluated using an independent t-test. Statistical significance was set at p-value < 0.05. Result showed significant higher differences in the mean serum levels of DHEA (87.40±65.90), LH (34.7±36.1), FSH (19.61±14.73) and Testosterone (3.04±1.36) in women with PCOS compared with the control (1.035±0.54),( 20.76±18.1), (13.2±10.19), and (3.04±1.36)(p< 0.05) respectively. A higher significant difference exists in the mean serum MDA values of the test group (women with PCOS compared with the control group(p<0.05). This study concluded that oxidative stress and hormone imbalance occurred among participants with PCOS attending the gynecology clinic of Nnamdi Azikiwe University Teaching Hospital in Nnewi. 
Keywords: PCOS, Estradiol, DHEA, luteinizing hormone, FSH, progesterone, Testosterone, TAC
Ananas comosus (Pineapple): A Comprehensive Review of Its Medicinal Properties, Phytochemical Composition, and Pharmacological Activities
Authors: Sharma Ankit , Kumar Lalit , Malhotra Meenakshi , Singh Amar Pal , Singh Ajeet Pal
Published: May 2024

Herbal medicine, also known as phytomedicine, utilizes various plant parts like leaves, fruits, roots, bark, or flowers for their health benefits, standing as an alternative healthcare approach to conventional medicine. Traditional herbal remedies, integral to medical systems worldwide, notably in China and India, are gaining global recognition for their efficacy and fewer side effects. Approximately 80% of the world's population relies on traditional herbal medicine for primary healthcare, as per the World Health Organization. Ananas comosus (L.) Merril, commonly known as pineapple, belongs to the Bromeliaceae family, encompassing about 50 genera and 200 species. Pineapple, a perennial herbaceous plant, exhibits unique physical attributes, with its main parts including the stem, leaves, peduncle, multiple fruit, crown, shoots, and roots. Pineapple contains various amino acids, including tyrosine and tryptophan, along with bromelain, an enzyme aiding digestion by breaking down proteins. This review outlines previous research on the phytochemical and pharmacological characteristics of Ananas comosus, highlighting its diverse medicinal properties. From antimicrobial and anticancer activities to antioxidant, anti-inflammatory, and hepatoprotective effects, pineapple demonstrates significant therapeutic potential across multiple health domains. Additionally, its nutritional value and traditional uses further underscore its importance as a versatile herbal remedy.
Keywords: Ananas comosus, pineapple, phytochemicals, pharmacological activities, medicinal properties, bromelain.
Sero-prevalence of hepatitis B virus and associated factors among pregnant women attending antenatal care in Bosaso general hospital, Puntland, Somalia 2023: A cross-sectional study design
Authors: Ahmed Mohyadin Abdullahi , Ibrahim Ahmed Mohammed , Yusuf Ramadan Budul , Yusuf Beder Jama , Mahamud Abdirahman Muhumed , Duale Fatima Said , Ali Mustafe Abdi , Farah Mustafa Mohamud
Published: May 2024

Background: Hepatitis is an inflammation of the liver caused by a variety of infectious and non-infectious agents, leading to a range of health problems. Hepatitis B virus (HBV) can cause    both acute and chronic liver disease, and the most common virus that can be transmitted from mother to child and other modes of transmission are contact with blood or other body fluids during sexual intercourse, unsafe injections, or exposure to sharp instruments.
Objective: To determine the seroprevalence and associated factors of HBV infection among pregnant women attending the Antenatal Clinic at Bosaso General Hospital, Puntland, Somalia, in 2023.
Methods: A cross-sectional study was conducted among 302 pregnant women who underwent routine ANC at Bosaso General hospital from March 15 to May 15. Study participants were interviewed using a structured questionnaire. A systematic random sampling technique was used to identify participants. Data entry, editing, and cleanup of the collected data were performed by the principal investigator using EPI data, and data analysis was performed using SPSS software version 20 to examine the association between each independent variable and the outcome variable. Bivariate and multivariate logistic regression analyses were performed to determine associations.
Result: A total of 302 respondents participated in the study, with a response rate of 96.8%. The overall prevalence of hepatitis B infection among pregnant women was 6.6% (95% CI = 4.0–9.8). Having a history of dental procedures (AOR = 5.52, 95% CI = 1.190–25.68), a history of blood transfusion (AOR = 5.02, 95% CI = 1.088–23.19), a history surgical procedure (AOR = 4.7, 95% CI = 1.014–21.76), or having a family history of HBV infection (AOR = 10.07, 95% CI = (1.27–79.63) were significant predictors of HBV infection among pregnant women.
Conclusion: The seroprevalence of HBV was intermediate (2–8%) in the study area according to WHO classification. A history of dental procedures, blood transfusion, surgical procedures, and a family history of hepatitis B virus infection were significantly associated with HBV infection.
Keywords: Sero-prevalence; Bosaso; hepatitis B virus; pregnant women.
Advances in Local Anesthesia and Pain Management for Practicing Dentists: A Comprehensive Review
Authors: Rout Manisha , Tomar Nitin , Kaushik Mayur , Singh Soundarya
Published: May 2024

One of the most frequent problems that patients bring to a dental clinic is pain in the orofacial region or within the tooth. To identify and solve the issue, a proficient practitioner needs to be equipped with the necessary information and resources. Comprehending the history of pain control in dentistry can provide valuable understanding into the development of the present techniques. Newer and more effective pain management treatments have been created as dentistry continues to advance. Several modalities have been developed to reduce and eliminate this, including pharmacological and non-pharmacological treatment modalities. The goal of the present review of the literature's findings is to provide dentists with reliable information regarding the application of contemporary local anesthetics, alternative methods, and strategies to reduce pain during anesthesia administration, thereby improving patient comfort.
Keywords: Local Anesthesia, Anesthetic Agents, NSAIDS, Lignocaine, Management, Pain Control
Release profile of encapsulated microparticles based on Landolphia owariensis (Apocynaceae) extract contained in suppositories for the treatment of hemorrhoidal crisis
Authors: DALLY Laba Ismael , ANIN Apo Laurette , N’GUESSAN-GNAMAN Kakwokpo Clémence , LIA Jose Gnahoré
Published: May 2024

Introduction: Hemorrhoidal disease is one of the most frequent causes of anal complaints. The general aim of this study was to evaluate the release profile of the encapsulated drug, in order to overcome the limitations of conventional galenic forms, while maintaining their efficacy.
Methods: Determination of the active ingredient contained in Landolphia owariensis extract was carried out by UV-Visible spectrophotometry. Release studies were carried out in a continuous flow cell. The dissolution profile of the suppository containing microparticles was compared to the dissolution profile of suppositories containing the unencapsulated extract and to that of Landolphia owariensis extract-based microparticles.
Results: The percentage of active ingredient released from suppositories containing microparticles and those containing the extract alone was 69.47% and 80.01% respectively. Flavonoid release from suppositories containing microparticles was slower, with a release rate of 6.31µg/mm, slightly close to the release rate of extract based microparticles (7.37µg/mn); in contrast, in vitro flavonoid release from suppositories containing the extract was faster (19.85µg/mm).
Conclusion: Release trials have shown the influence of the sodium alginate matrix system on PA release kinetics. These innovative suppositories will help improve compliance and the treatment of hemorrhoidal crisis.
Keywords: Microparticles, Suppositories, Landolphia owariensis, Hemorrhoids, In vitro release
Soil-Transmitted Helminthiasis, Intestinal Schistosomiasis and Malaria Co-Infections among Children in Rural Communities Around Rwasave and Cyarwa Valleys
Authors: Jeannine UWIMANA , PRUDENCE ISHIMWE ALAIN , Leon MUTESA , Evariste NTEZIRIZAZA , Jean De Dieu Tuyishime
Published: May 2024

Background: Soil-transmitted helminthiasis, schistosomiasis and malaria remain a threat in developing countries, especially to people living in rural areas near large water bodies, valleys or swamps whose daily life activities revolve around those areas. In addition, these parasites affect different groups of people especially those in contact with their breeding sites including children mostly due to their developing immunity compared to that of old people. 
Methodology: This cross-sectional study was conducted in rural communities near the Rwasave and Cyarwa valleys, with 124 school-aged children participating. Stool samples were tested for the presence of STH eggs and intestinal Schistosoma parasites using the Kato Katz technique, and thick blood smears were made to aid in the identification of plasmodium species in blood. The threshold intensity of infection on STHs and Schistosoma sp. was estimated by counting their eggs microscopically, which aided in classifying infections as light, moderate, or heavy according to WHO standards. Furthermore, Plasmodium species were identified by the presence of schizonts, trophozoites, or gametocytes on Giemsa-stained thick blood smears, and parasitic density was calculated as a result.
Results: In this study, the highest prevalence of soil transmitted helminthiasis was 12.7% in Cyarwa valley compared to 12.5% in Rwasave valley. The highest prevalence of Schistosomiasis was 3.2% in Cyarwa valley compared to 1.3% in Rwasave valley. Prevalence of malaria in Cyarwa valley was 3.3% in 63 children. Where children infected were only males falling in 5-8 age group.
Conclusion: Results showed high prevalence of soil transmitted helminthiasis which was 12.7% in Cyarwa compared to 12.5% in Rwasave valley especially in children aged 5-8, this due to poor sanitation (P<0.001) that have assessed. Surprisingly, Cyarwa valley is located nearby town. Whereas malaria, intestinal schistosomiasis was low and there were not significantly associated with their risk factors with p-values 0.4, 0.092 respectively which can show that, preventive measures that have been established by government of Rwanda have positive impacts. Furthermore, there was a low prevalence of soil transmitted helminthiasis, intestinal schistosomiasis and malaria co-infection.
Keywords: soil transmitted helminthiasis, intestinal schistosomiasis, malaria.
Teatro x la Memoria desde dos dramaturgas mendocinas: Sonnia De Monte y Susana Tampieri
Authors: Calabrese Daiana Marcela
Published: May 2024

Se realizará un camino para ir desde la macro a la micropolítica de la historia Argentina de la Posdictadura, para poder focalizar en el Teatro x la Memoria en los textos seleccionados de las dramaturgas mendocinas: Sonnia de Monte y Susana Tampieri. ¿Cómo son las mujeres que escriben lo que escriben? ¿por qué escriben lo que escriben? ¿Qué quieren o intentan transmitir en sus escritos? ¿Qué representan cuando escriben? Y desde las posibles respuestas, encontrar un “nuevo camino” en la enunciación para poder abordar sus dramaturgias.
Estrategias de intervención organizacional en equipos de trabajo
Authors: Castro Méndez Naiby Verónica , Márquez-Amaro Raymundo
Published: May 2024

Introduction: the development of new skills in the work environment such as leadership, work teammanagement, equitable collaboration, effective communication, solid commitments or integrationof new human values, acquires an important meaning for the stability of the work environment inmodern organizations. . Objective: the objective of the research is to report on the result of theimplementation of an organizational intervention strategy on strengthening the integration skills ofeffective work teams in the daily practices of the Cristafácil company and the experience acquiredby the actors involved as a learning society (UNESCO, 2014). Methodology: The interventionstrategy process is based on Kurt Lewin’s action research methodology, which is used to studya specific problem and/or needs of a certain group of people. Results: communication was oneof the main factors that benefited from the organizational intervention strategy. The well-being and work dimension was the one that stood out with the greatest favorable difference, which arefactors to understand how organizations improve organizational processes and their results.
THE FILM 'PESANTREN' AND RELIGIOUS TOLERANCE IN INDONESIA: REALITY, REPRESENTATION AND IDEOLOGY
Authors: Fatihunnada Fatihunnada , Abdullah Irfan Mas’ud , Hasbi Rusli , Ummah Sayidatul
Published: May 2024

This article aims to explain the form of religious tolerance values in the documentary film 'Pesantren' which was released in 2022. This film is interesting because it reveals the educational side of religious tolerance in Indonesia, which shows another side of pesantren, which is considered by some to be a hotbed of indoctrination of radical and fundamental religious views. Through descriptive qualitative method, this article focuses on the value of religious tolerance in the film presented through verbal and non-verbal signs. The data is analyzed using John Fiske's semiotic theory that explains the codes of television, namely the level of reality, the level of representation and the level of ideology. This theory is useful to reveal the meaning behind each scene. This article shows that in the film Pesantren, the value of tolerance is more dominant after reading the ideology stage. The value of tolerance in the film is present in the frame of inter and intra-religious tolerance. The value is instilled in three major narratives, namely: respecting differences of opinion, avoiding fanaticism because God's love is also unlimited, preaching with good words and staying away from discrimination against people of different beliefs.
The return of Nipah virus in India: Challenges and Recommendations
Authors: E Um Abiha Batool , Ahmad Zobia , Rahmat Zainab , Patel Hinal , Mousavi Sayed Hamid , Hasibuzzaman Md. Al
Published: May 2024

Viruses have consistently posed a significant threat to global health,
varying in their effect from mild asymptomatic cases to full-blown
incapacitating illnesses. India, a country with a tremendous population
of over 1.3 billion, encounters unique challenges when managing public
health crises, such as the recent re-emergence of the deadly zoonotic
Nipah virus (NiV) in Kerala. Our commentary highlights the history of
NiV outbreaks in light of the two primary pathways of virus
transmission, animal-to-human and human-to-human. We discuss common
presenting symptoms of NiV and risk factors contributing to its spread,
proposing possible measures to tackle the current challenges in timely
diagnosis and infection control. Owing to its high mutation and
mortality rate, the NiV outbreak could have potentially transitioned
into the next global pandemic, which calls for the implementation of
stringent policies and infective protocols by the government and health
authorities to curb any future outbreaks.
Unveiling a Hidden Pocket in HIV-1 Protease: New Insights into Retroviral Protease Cantilever-Tip Region Characteristics
Authors: Sherry Dean , Sayed Yasien
Published: May 2024

The HIV-1 protease is critical for the process of viral maturation,
making it an attractive target for antiretroviral therapy. As such it is
one of the most well characterised proteins in the Protein Data Bank.
There is some evidence to suggest that the HIV-1 protease is capable of
accommodating small molecule fragments at several locations on its
surface outside of the active site; namely, the Exo site, flap-top
pocket, face site, and Eye site. However, some pockets on the surface of
proteins remain unformed in the apo structure and these “cryptic
sites” have also been known to accommodate small molecule ligands. To
date, no cryptic sites have been identified in the structure of the
HIV-1 protease. Here, we characterise a novel cryptic cantilever pocket
on the surface of the HIV-1 protease through mixed-solvent molecular
dynamics simulations using several probes: acetone, benzene, imidazole,
isopropanol, and phenol. Structure-based analysis of the cryptic
cantilever pocket suggest that the pocket may be amenable to ligand
binding. Interestingly, we note that several homologous retroviral
proteases exhibit evolutionarily conserved dynamics in the cantilever
region and possess a conserved pocket in the cantilever region.
Immobilisation of the cantilever region of the HIV-1 protease via
disulphide cross-linking resulted in curling-in of the flap tips and the
propensity for the protease to adopt a semi-open flap conformation.
Together these results suggest that the mobility of the cantilever
region plays a key role in the global dynamics of retroviral proteases.
Moreover, the cryptic cantilever pocket of the HIV protease may
represent an interesting target for future fragment-based ligand
screening campaigns.
Transient Power Overshoot Suppression Strategy of Generalized Droop Control with Constrained RoCoF
Authors: Wu Qinghui , Lin Hengwei , Zhang Chunjiang , Zhang xiaoyu , Wang Fuxi
Published: May 2024

With the renewable energy continuously access to the microgrid,
the microgrid itself does not have the disadvantages of the inertia of
the synchronous generator in the traditional grid is increasingly
apparent, for which the generalized droop control (GDC) strategy is
proposed. In the normal operation of the system, GDC has the advantages
of large inertia and small active power overshoot, but when subjected to
external frequency perturbations, the grid-supporting inverter with
large virtual inertia is prone to large transient active power overshoot
and oscillation.
To address this problem, the article
establishes small-signal models under different perturbations based on
the GDC compared with the virtual synchronous generator (VSG) and
further proposes two adaptive inertia control strategies: GDC adaptive
inertia (GDCAI) and adaptive inertia for operation mode switching
(AIOMS). By adjusting the virtual inertia appropriately, the rate of
change of frequency (RoCoF) is maintained in the set range while
improving the transient performance of the system, the methods of
reduce-order of the system model and control parameter design is given,
to reduce the frequency fluctuation while greatly reducing the active
power overshoot and improving the response speed of the system.
The effectiveness of the two control strategies is verified by
MATLAB/Simulink simulation and StarSim hardware-in-the-loop (HIL)
experiment.
Outcomes of hypercalcemia in patients with Multiple Myeloma: A Population-Based Study Using National Inpatient Sample (NIS) Database
Authors: Iqbal Rabia , Iqbal Qamar , Bajwa Ahmad Taimoor , Marowa Sabrin , Jafar Amina , Ramos Ana Colon , Sinha Samridhi , Anwer Faiz
Published: May 2024

Background: Multiple myeloma (MM) has different complications,
including renal failure, anemia, infections, metabolic complications,
and skeletal problems. Hypercalcemia is the most common metabolic
complication, and the presence of hypercalcemia indicates worse
outcomes. Aims: The study aims to examine outcomes such as
hospitalization costs, length of stay, survival rates, and the incidence
of complications of hypercalcemia in multiple myeloma patients admitted
in the United States from 2017 to 2020. Methods: We performed a
retrospective analysis using the National Inpatient Sample database to
determine the incidence of hypercalcemia in patients admitted to United
States hospitals from 2017 to 2020. Univariate and multivariate logistic
regression were used to calculate the odds ratio. We used STATA software
17 to perform the analysis. Results: We found that the total
number of patients with MM was 437799, out of which 8.6% had
hypercalcemia. The mean age of the patients was 69 years, and
hypercalcemia was found to be more common in males (55%) than females
(45%). The presence of hypercalcemia was also associated with increased
mortality (adjusted odds ratio 1.3, p-value 0.00). It was also seen that
MM patients who had hypercalcemia had a higher risk of complications,
including acute kidney injury (OR 3, p<0.05), hyperkalemia (OR
1.8, p-value <0.05), metabolic acidosis (1.4, p-value
<0.05), spinal cord compression (OR 0.9, p-value
>0.05), increased length of stay (OR 3, p-value
<0.05), and higher cost of hospitalizations (p-value
<0.05). Conclusion: The data is also limited to the
demographic characteristics, impact, and outcomes of hypercalcemia on
patients with MM. This study contributes valuable insights into the
clinical implications of hypercalcemia in patients with multiple myeloma
(MM). It fills existing gaps in the literature by utilizing a large
population-based dataset.
Ambient mass spectrometry and machine learning-based diagnosis system for acute coronary syndrome
Authors: Tran Que N.N. , Moriguchi Takeshi , Ueno Masateru , Iwano Tomohiko , Yoshimura Kentaro
Published: May 2024

Aims: The purpose of this study is to establish a novel diagnosis system
in early acute coronary syndrome (ACS) using Probe Electrospray
Ionization-Mass Spectrometry (PESI-MS) and machine learning (ML) and to
validate the diagnostic accuracy. Methods: Total 32 serum samples
derived of 16 ACS patients and 16 control patients were analyzed by
PESI-MS. The acquired mass spectrum dataset was subsequently analyzed by
partial least squares (PLS) regression to find the relationship between
two groups. Support vector machine (SVM), a method of machine learning,
was applied on the dataset to construct the diagnostic algorithm.
Results: Control and ACS groups were separated into the two clusters in
PLS plot, indicating ACS patients differed from the control in the
profile of serum composition obtained by PESI-MS. The sensitivity,
specificity and accuracy of our diagnostic system were all 93.8%, and
the area under the receiver operating characteristic curve showed 0.965
(95%CI: 0.84-1). Conclusion: The PESI-MS and ML-based diagnosis system
is likely an optimal solution to assist physicians in ACS diagnosis with
its remarkably predictive accuracy.
Rezisztenciaviszonyok elemzése Escherichia coli és Klebsiella spp. húgyúti izolátumokban ismert és újszerű, klinikailag releváns indikátorok felhasználásával: 10 éves retrospektív vizsgálat [Analysis of resistance trends in urinary Escherichia coli and Klebsiella spp. isolates using known and novel indicators of clinical relevance: a 10-year retrospective study]
Authors: Gajdács Márió , Ábrók Marianna , Lázár Andrea , Burián Katalin
Published: May 2024

Bevezetés: Az antibiotikumokkal szemben rezisztens bakteriális kórokozók megjelenése és terjedése világszerte egyike a legfontosabb népegészségügyi problémáknak. Az utóbbi években számos új bakteriális rezisztenciakritérium került közzétételre, a rezisztenciaadatok és a klinikai kimenetel közötti korreláció javításának céljából. Anyag és módszer: Jelen tanulmányban mikrobiológiai- és rezisztenciaadatok retrospektív gyűjtése történt, a 2008. 01. 01 – 2017. 12. 31. közötti (10 éves) periódusra vonatkozóan az SZTE ÁOK Klinikai Mikrobiológiai Diagnosztikai Intézetében. Az adatok elemzése során a bakteriális izolátumokat különféle rezisztenciakategóriákba soroltuk (vad típusú, UDR, MDR, XDR, PDR, illetve DTR és mDTR). Eredmények: A tízéves vizsgálati periódus alatt n=16 240 (76,8%) járóbetegmintából és n=13 386 (69,3%) fekvőbetegmintából került izolálásra Gram-negatív baktérium (p=0,038). Az E. coli izolátumokra vonatkozóan a vad típusú törzsek 34,1-39,4%-át tették ki az összes izolátumnak, míg a Klebsiella spp. törzsek esetén 40,4-45,7%-ot. Az UDR-izolátumok prevalenciája az E. coli izolátumokra vonatkozóan 2013-ban volt a legalacsonyabb és 2011-ben a legmagasabb, a Klebsiella spp. esetében 2017-ben volt a legalacsonyabb és 2011/2013-ban a legmagasabb. Következtetés: A klinikumközpontú filozófiáján túlmenően, a DTR (és annak a jelen ebben a tanulmányban részletezett módosításai) a betegágy mellett és a klinikai gyakorlatban történő alkalmazása jelentős előnyökkel járhat a klinikai adatokkal összefüggésben.
A húgyhólyag in situ karcinóma és interstitialis gyulladás elkülönítésének nehézségei 5 eset kapcsán = Difficulties in the Distinguish Between in situ Carcinoma and Interstitial Cystitis of the Bladder based on 5 Cases
Authors: Bécsi Áron , Nyirády Péter , Székely Eszter , Majoros Attila
Published: May 2024

Bevezetés: A húgyhólyag in situ karcinóma (CIS) és az interstitialis cystitis (IC) gyakran hasonló megjelenésű lehet, azonban különböző kezelést igényelnek. A differenciáldiagnosztika sokszor nehéz feladat elé állítja a vizsgáló orvosokat. A szerzők esetbemutatások kapcsán próbálják bemutatni a két kórkép azonosságait, eltéréseit. A biztonságos kezelés érdekében javaslatot tesznek a gyakorlat számára alkalmazható elkülönítő kórismézésre. Esetismertetések (betegek és módszer, eredmények): Öt beteg esetét ismertetik, akiknél a vizelési panaszok alapján felmerült IC lehetősége, ugyanakkor az elvégzett szövettani vizsgálat CIS-t igazolt. A hisztológia eredménye alapján az IC gyanús panaszokkal jelentkező betegeknél további onkológiai kezelés történt. Következtetések: Bár az IC és CIS hasonló vizelési panaszokat okozhat, alapvető fontosságú a két kórkép biztonságos elkülönítése, mivel azok teljesen különböző kezelést igényelnek, továbbá az IC invazív kezelése CIS esetén a folyamat progressziójához vezethet. A biztos diagnózis csak szövettani mintavétel alapján lehetséges. Ezért a szerzők véleménye szerint IC gyanúja és emiatt tervezett invazív kezelés előtt, amennyiben esetleges malignitás lehetőségét klinikailag teljes biztonsággal nem tudjuk kizárni, feltétlenül szükséges a húgyhólyag-biopszia elvégzése CIS kiszűrése céljából.