bluuebunny/crossref_metadata_2025 huggingface dataset:
Norman Girvan y las relaciones internacionales desde el Caribe anglófono: dependencia e integración
Authors: Montañez Pico Daniel , Calderón Rodríguez José María
Published: October 2023

Norman Girvan (1941-2014) fue uno de los más prominentes intelectuales críticos de Jamaica. Su trabajo se centró en el estudio sociohistórico del Caribe anglófono, con especial énfasis en el origen de su dependencia y subdesarrollo crónico dentro del sistema capitalista mundial. Confiando en que la integración sería una de las claves para superar la dependencia dentro del sistema de relaciones internacionales contemporáneo, en la última etapa de su vida se dedicó al análisis de los proyectos de integración regional de su área, convirtiéndose en el teórico y político mejor formado en este campo. En el artículo se analiza su trayectoria intelectual, ponderando sus aportes a la comprensión de las relaciones internacionales desde el Caribe anglófono a través de sus estudios sobre dependencia e integración.
Pablo González Casanova. Pensar para ganar: la subversión del pensamiento
Authors: Roitman Rosenmann Marcos
Published: October 2023

Pensar no es una tarea fácil, requiere esfuerzo, disciplina, capacidad crítica. Pero también compromiso y humildad. Los acontecimientos que forjan la conciencia marcan las trayectorias vitales. El saber crítico, interroga al poder. Requiere valentía, convicción. Quienes toman el camino de subvertir el pensamiento tienen la virtud de observar el mundo con mirada crítica. Pablo González Casanova es uno de ellos. Sobresale por su comportamiento ético y coherencia. Brega a contracorriente y, en no pocas ocasiones, sufre la censura del poder dominante. Pablo González Casanova forma parte de quienes luchan por la justicia social, la igualdad, dedicando su vida a la defensa de los derechos humanos, la democracia, la libertad.
John Saxe-Fernández (coordinador), Fidel: 17 aproximaciones
Authors: Cano Ramírez Omar Ernesto
Published: October 2023

El 25 de noviembre de 2016, Fidel Castro Ruz, líder de la Revolución Cubana y figura política del Caribe, de América Latina y del mundo, falleció en La Habana, Cuba. La población de la isla llenó calles y plazas para despedirlo. Entre gritos, llantos, tristeza y dolor el pueblo cubano dio el adiós material a su líder histórico. Millones de voces gritaban al unísono “Yo soy Fidel”. A los pocos días de la despedida, Pablo Gentili, entonces secretario ejecutivo del Consejo Latinoamericano de Ciencias Sociales (CLACSO), propuso a un grupo de intelectuales de la región realizar un volumen en homenaje a la vida y obra de Fidel Castro. La tarea la asumió John Saxe-Fernández, quien reunió a 17 autoras y autores para rendir homenaje con pluma y papel. El resultado fue el libro Fidel: 17 aproximaciones.
Creencias explícitas e implícitas, sobre la ciencia y su enseñanza y aprendizaje, de una profesora de química de secundaria
Authors: Peme-Aranega Carmen , De Longhi Ana Lía , Baquero María Elena , Mellado Vicente , Ruiz Constantino
Published: October 2023

En esta investigación pretendemos, tomando como marco teórico una teoría sustantiva, analizar y comparar las creencias epistemológicas y didácticas, explícitas e implícitas, de una profesora de química de secundaria. Las explícitas se determinan a partir de inventarios y entrevistas, y, las implícitas, a partir de la ejecución de actividades específicas llevadas a cabo en las fases preactiva, interactiva y postactiva de su tarea docente. Los resultados nos indican que en el caso de “Gabriela” existe bastante consistencia entre sus creencias explícitas e implícitas, siendo mayor la coincidencia en las epistemológicas que en las didácticas. En concordancia con otras investigaciones de expertos, sus creencias implícitas son un poco más actualizadas que las explícitas.
Presentación del dossier Historia intelectual de (y desde) América Latina. Parte 1
Authors: Concheiro San Vicente Luciano Concheiro
Published: October 2023

Dossier: "Historia intelectual de (y desde) América Latina", parte 1.
Prácticas y usos en torno al impreso: su circulación en la red intelectual de Manuel Ancízar. Sur América-mediados del siglo XIX
Authors: Granados Aimer
Published: October 2023

Esta investigación se centra en el análisis de las condiciones sociales de la circulación de impresos en el espacio cultural/intelectual y geográfico de una buena parte de la cuenca del océano Pacífico de Sur América. En tal circulación se ponen de manifiesto algunas de las prácticas y estrategias que los involucrados en el intercambio de impresos implementaron con el fin de salvar múltiples circunstancias que obstaculizaban el tránsito de impresos: un medio geográfico muy complicado, circunstancias socioeconómicas y políticas muy difíciles y Estados-nación en vías de formación. El estudio se centra en el intercambio y recepción de impresos e ideas que realizó la red intelectual del neogranadino Manuel Ancízar, que involucró a diferentes intelectuales de la zona en estudio. La investigación toma como fuente primaria principal parte de la correspondencia de Ancízar que reposa en el Archivo de la Universidad Nacional de Colombia, sede Bogotá.
Reseña: Virginia Moratiel, "Cuando lo infinito asoma desde el abismo. Estudios sobre el romanticismo en lengua alemana e inglesa"
Authors: Matus Ramírez Guadalupe
Published: October 2023

Reseña: Virginia Moratiel, Cuando lo infinito asoma desde el abismo. Estudios sobre el romanticismo en lengua alemana e inglesa. Escrita por Guadalupe Matus Ramírez.
Archivo Dominique Jonard
Authors: Jonard Méndez Noyule Dominique , Noguez Medina Leilani
Published: October 2023

Curar un archivo: conformación del Archivo Dominique Jonard (ADJ).
Experimental Investigation of Compressive Strength of Concrete through Conventional Concrete Mixer and Design of Automated Concrete Mixer with Machine Learning
Authors: Patle Mr. Kamlesh Dayanand
Published: October 2023

Abstract: Various issues with concrete mixing in concrete mixer machines have been observed. Engineers and employees can only make guesses and predictions based on the concrete they can see; they cannot determine the proper mixing of the concrete. However, there are times when the ratio is not kept even when the concrete is correctly mixed. In the difficult, multi-step process known as concrete mix design, we look for the ideal component ratio to produce concrete that functions properly. There are other ways to make concrete mixtures, but the Three Equation Method-based techniques are the most widely used. Compressive strength, which establishes the concrete class, is among the most significant characteristics of concrete. The compact strength that can be predicted is [4]
Empowering Candidates with Experience Sharing and Advanced Resume Screening - A Comprehensive Survey
Authors: Bachate Shreyash
Published: October 2023

Abstract: In the dynamic realm of higher education and career advancement, our college community now has access to a transformative portal. Here, students can delve into a vast repository of real-world interview experiences shared by peers, alumni, and industry professionals. These firsthand accounts offer a unique opportunity for current students to gain an inside perspective on interview processes, company cultures, and expectations across various organizations. Furthermore, our portal boasts a cutting-edge resume analysis feature. Students can upload their resumes, and a sophisticated algorithm scrutinizes their qualifications, skills, and experiences. Utilizing this analysis, the system generates tailored recommendations for companies and positions that closely align with each student’s unique profile, academic background, and career aspirations. This streamlines the job search process, broadens students’ horizons, and empowers them to explore career opportunities they might not have considered otherwise. Our aim is to facilitate professional growth, ensuring that our students seamlessly transition into the workforce. By fostering the sharing of interview experiences and delivering personalized company suggestions, our platform equips students to make informed career decisions, enhance their job application strategies, and embark on successful career paths.
Evaluating the use of cheaper, less effective medications in patients with cost-based medication nonadherence
Authors: Hasso Muneer F.
Published: October 2023

A clinical decision report using:

Sangaralingham LR, Sangaralingham SJ, Shah ND, Yao X, Dunlay SM. Adoption of Sacubitril/Valsartan for the Management of Patients With Heart Failure. Circ Heart Fail. 2018;11(2):e004302. https://doi.org/10.1161/circheartfailure.117.004302

for a patient with low medication adherence rates due to the high out-of-pocket costs of newer medications.
Early closure of colostomy from abdominal trauma may be beneficial in otherwise healthy patients
Authors: Xu Nicole
Published: October 2023

A clinical decision report using:

Khalid MS, Moeen S, Khan AW, Arshad R, Khan AF. Same admission colostomy closure: a prospective, randomised study in selected patient groups. Surgeon. 2005;3(1):11-14. https://doi.org/10.1016/s1479-666x(05)80004-6

for a patient with loop transverse colostomy due to trauma
Comparison of functional outcome between Bipolar Hemiarthroplasty and total Hip Arthroplasty for displaced femoral neck fractures in elderly patients
Authors: Abdalnabi Alwan Al-Tamimi Ali , Ali Rafiq Barawi Omer , Mohammed Ali Kareem Rawand
Published: October 2023

Objectives: The intention of this study to compare functional outcomes between Total Hip Arthroplasty and Bipolar Hemi Arthroplasty for displaced femoral neck fracture after 3 months and 1 year from injury in elderly patients. Methods: Prospectively 43 patients were enrolled in this study, ages more than 60, twenty-four of them managed by Total Hip Arthroplasty, and 19 were managed by Bipolar Hemi Arthroplasty. These patients were followed up postoperatively for one year, at (3 and 12 months), to compare functional outcomes using Haris Hip Score. Results: Duration of operation was significantly higher in Total Hip Arthroplasty (98.54 min) versus (62.63 min) in the Bipolar Hemi Arthroplasty group, and intra-operative blood loss also considerably higher in Total Hip Arthroplasty (322.5 ml) than Bipolar Hemi Arthroplasty (178.42 ml). Regarding complications, there is no difference between the two groups; however, the incidence of mortality higher in the Bipolar Hemi Arthroplasty population. Average Haris Hip Score, pain and the motion were significantly better after three months and one-year follow-up in the Total Hip Arthroplasty group. The function was nearly the same at both groups after three months but after one-year of follow-up function significantly better (p-value <0.5) in the Total Hip Arthroplasty patients.Conclusion: Total Hip Arthroplasty provides better functional outcomes after three months and one year of follow-up than Bipolar Hemi Arthroplasty when used to manage femoral neck fracture for active old age patients. Bipolar Hemi Arthroplasty may be suitable for older inactive patients with narrow life expectancy with multiple comorbiditie
Chitosan-iron oxide nanoparticle preparation and performance as a lipid-lowering agent in serum patients with nephrotic syndrome
Authors: Dawood Salman Ahmed , M. Hameed Rana , Hameed Odda Atheer
Published: October 2023

Objective: The main objectives of this study was to Prepare and study the structural features of chitosan/iron oxide nanoparticles CS-FeO NPs and to examine the applications of chitosan nanoparticles as a lipid-lowering agent in children with nephrotic syndrome

Method: The preparation processes for nanoparticles are described in depth. Chitosan nanoparticle applications are shown. X-ray diffraction patterns (XRD) indicated that the magnetic Fe3O4 nanoparticles were pure Fe3O4 with a spinel structure and the coating of chitosan did not result in a phase change.

Results: The coating of CTS onto the Fe3O4 nanoparticles was also demonstrated by the measurement of Fourier transform infrared (FTIR) spectra. Magnetic measurement revealed that the saturated magnetization of the Fe3O4–chitosan nanoparticles reached +18.3 mV and the nanoparticles showed the characteristics of superparamagnetic.

Conclusion: Magnetic Fe3O4–chitosan nanoparticles were prepared successfully by the covalent binding of CTS on the Fe3O4 nanoparticles. These microspheres was apply to the magnetic-field-assisted lipid lowering processes.
Effects of Smoking on Serum Ferritin levels in adult population living in Sulaymaniyah, Iraq: A Retrospective Cross-sectional Study
Authors: M. Hadi Jihad , B. Shawkat Shanya , Gh. Rauf Hwda , A. Hama Karim Soma , M. Mustafa Ayman , N. Muhammad Soz , S. Abdullah Mhamad
Published: October 2023

Background: Smoking is a serious issue for global public health, and the prevalence of smoking use is the leading cause of early mortality globally. Serum ferritin, an intracellular protein that stores and releases iron, is considered one of the most important clinical biomarkers to assess iron status.

Aim: The current study aims to examines the effect of smoking on serum ferritin levels of adult populations in Sulaymaniyah. 

Methods: The study was conducted on 80 smokers and 20 non-smokers, totally 100 persons. Their ages ranged from 18 to 65 years.

Results: Result showed that the majority of smokers had elevated ferritin levels. A p-value of less than 0.05 indicated a significant difference in ferritin levels between smokers and non-smokers groups. The average ferritin level among smoker group was 227.40 mg/L, while the average ferritin level among non-smokers group was 118.3 mg/L. Regarding the associated between age groups and average ferritin levels, the average ferritin level is highest in the age groups between 51-61 years old. In addition, obesity may play a role in raising ferritin levels, people with obese conditions (BMI > 30) have the highest average ferritin levels than others.

Conclusion: This study provides evidence that smoking negatively affect serum ferritin levels, since increases in mean ferritin levels are very striking in smoking and obese group.
El bambú Tonkin (Pseudosasa amabilis) como material a explorar en el Ecodiseño. El diseño de un puesto de mercado como caso de estudio
Authors: González-Yebra Óscar , Lozano Rey Adrián , Tolón Becerra Alfredo , Takeuchi Caori Patricia
Published: October 2023

El análisis del ciclo de vida (ACV) permite evaluar el impacto ambiental en las diferentes etapas de un diseño/producto. En el caso de la etapa de selección de materiales, entre las materias primas que tienen un mayor impacto ambiental y alto consumo energético se encuentra el acero. En este contexto, en esta investigación se estudia el uso del bambú Tonkin (Pseudosasa amabilis) como material estructural y estrategia de Ecodiseño, se compara su impacto medioambiental con el del acero en un rediseño de un puesto de mercado para frutas y verduras. Para llevar a cabo el proceso de diseño, se ha trabajado bajo el enfoque de Diseño para la Sostenibilidad (D4S) con la herramienta SolidWorks®, en la que se ha desarrollado el diseño de detalle, incluyendo el estudio del comportamiento estático y ACV, es decir, el estudio de la sostenibilidad de la estructura en el marco del nuevo paradigma de la Economía Circular. Se realizó el rediseño con bambú Tonkin, a partir de un muestreo que arrojó unos datos medios de 30 mm de diámetro y espesor de 6 mm. Los resultados obtenidos, de forma teórico-experimental y con la simulación númerica, confirman el bambú Tonkin tanto en el análisis de elementos finitos (FEA) como en el estudio de sostenibilidad (ACV), es un material con unas excelentes cualidades estructurales a la vez que tiene un impacto medioambiental mínimo. Es por ello, que se proponen nuevas líneas de trabajo y se invita a otros grupos de investigación a que se interesen sobre este material verde desconocido.
Thinning wood properties of Nothofagus alpina under three different silvicultural conditions
Authors: Wentzel Maximilian , Pesenti Héctor , Droppelmann Fernando , Rolleri Aldo
Published: October 2023

The main objective of this study was to assess the properties of Nothofagus alpina wood from thinning that originates from two sites with intensive silviculture and one similar to a secondary growth forest, with different soil, climatic conditions and age. To achieve this, some mechanical, physical and chemical-crystalline properties were characterized; studying the differences from pith to bark and between the selected trees that were taken from the thinning of the three plantations. Among the studied plantation sites, there were statistical differences in equilibrium moisture content, density and modulus of elasticity. Furthermore, FT-IR was able to differentiate the chemical-crystalline compositions from pith to bark and between plantations, while the X-Ray Diffraction showed differences in the crystallinity index. It was possible to differentiate between the sites with a more intense silvicultural intervention and the one with more variable growth conditions.
Productos de comunicación pública de la ciencia y la tecnología: el caso de la Universidad Nacional de Misiones
Authors: Rodríguez María Itatí
Published: October 2023

Este trabajo comparte avances de una investigación en curso que indaga sobre los sentidos en relación a la comunicación de la ciencia y la tecnología (CPCyT) por parte de investigadores/as de la Universidad Nacional de Misiones. Nos interesa reflexionar sobre el rol central de la comunicación social para la producción y comunicación de conocimientos científico-tecnológicos. Nuestro estudio indaga sobre formatos y medios utilizados por investigadores/as para comunicar los resultados de sus producciones. En este artículo nos centraremos en identificar, describir y analizar productos de CPCyT propuestos en proyectos de dicha Universidad durante el 2018–2020.
Detection of Lysteria monocytogenes in Frozen Meatballs Using Real-Time PCR
Authors: Sophian Alfi , Purwaningsih Ratna
Published: October 2023

Detection of pathogenic bacteria Listeria monocytogenes in processed food products of frozen meatballs is one of the critical test parameters in product quality testing. The challenge in testing product quality is how to find a reliable and effective test method to generate test results data. With this research, it is hoped that it can provide information or references for similar research. The method used in this research is the enrichment method with a direct isolation technique and amplification using real-time PCR. Data analysis was carried out based on 2 main criteria which included: (1) Ct analysis (Cycle threshold) and (2) melting temperature (Tm) analysis. From the results of the analysis using real-time PCR, the results of the tested samples were detected at Ct 11.60 with a Tm value of 81.50. For NTC control not detected, this indicates that the master mix used is in good condition and no contamination occurred when testing the sample. The use of this NTC control plays an important role in monitoring the quality of the master mic and test run. For the LOD control and positive control, the results were detected, whereas in the LOD control, the Ct value was detected at 10.08 and the Tm value was at 81.30. for positive control, the value of Ct was detected at 10.85 and the value of Tm was at 82.0. Based on the results of the study, it can be concluded that the test method used can detect Listeria monocytogenes in processed meat products in the form of frozen meatballs.
Análise de sentimentos: identificando sentimentos em comentários da Rede Humaniza SUS
Authors: Silva Eduardo Alves , Oliveira Luis Felipe Rosa de
Published: October 2023

A análise de sentimentos e áreas correlatas ao processamento de linguagem natural têm se tornado cada vez mais comuns em diversos contextos, seja no empresarial ou acadêmico. Esse tipo de análise facilita a compreensão a respeito de opiniões e sentimentos de diferentes indivíduos em relação a determinado produto ou temática. Ao levar em consideração a crescente difusão das redes sociais e a interação entre usuários nessas redes, a captação de dados para análise de sentimento se tornou mais simples do que era anos atrás, onde frequentemente eram utilizados questionários ou formulários para captar a opinião de uma pessoa a respeito de algo. Com esse intuito e com a alta densidade de informação da rede humaniza SUS (RHS), a primeira rede social brasileira criada a partir de uma política pública, voltada para o tema da humanização da saúde. A rede humaniza SUS torna-se um ambiente de estudo promissor para análise de sentimentos, fazendo-se uso de uma abordagem não supervisionada que visa o uso de um dicionário ou léxico de sentimentos criado com palavras em Português, e com a possibilidade de aplicação utilizando a linguagem de programação Python, para apresentar a classificação de sentimentos dos comentários feitos pelos usuários da rede.

Artigo apresentado no II Workshop de Informação, Dados e Tecnologia, realizado nos dias 27 a 29 de novembro de 2018, na cidade de João Pessoa (PB), nas dependências da Universidade Federal da Paraíba (UFPB). Disponível originalmente em: https://dadosabertos.info/enhanced_publications/idt/. Acesso em: 25 set. 2023.

Detentor do Copyright
VI Workshop de Informação, Dados e Tecnologia - WIDaT 2023
Gestão de dados da biodiversidade: aplicação do padrão de metadados Darwin Core
Authors: Soares Filipi Miranda , Hamanaka Raíssa Yuri , Maculan Benildes C. Moreira dos Santos
Published: October 2023

No contexto da gestão de dados de pesquisa e da necessidade de padronização do armazenamento e tratamento dos mesmos para posterior reutilização, torna-se imprescindível o uso de metadados para a representação dos dados. Devido a importância do uso de metadados para a recuperação de documentos, o estudo objetivou analisar a aplicação do padrão de metadados Darwin Core (DwC) em um registro de ocorrência do Portal da Biodiversidade. Para avaliar a aplicação do DwC pelo Portal da Biodiversidade, foi feita uma correlação entre os metadados do DwC com os metadados do registro de ocorrência do repositório, buscando-se entender o significado de cada metadado e se eles correspondem de fato aos metadados do DwC, uma vez que a documentação do Portal da Biodiversidade apresenta o DwC como padrão de metadados adotado. Dos 34 campos do registro de ocorrência analisados, a maioria tinha correspondência com os campos do padrão de metadados. Houve casos de duplicação de campos no repositório da biodiversidade, da criação de campos no repositório que não existiam no DwC e da existência de campo inadequado no repositório. A partir do exemplo do Portal da Biodiversidade é possível delinear a importância da curadoria digital, ao procurar agrupar conjuntos de dados semelhantes e estruturá-los de forma a possibilitar o reuso dos mesmos.

Artigo apresentado no II Workshop de Informação, Dados e Tecnologia, realizado nos dias 27 a 29 de novembro de 2018, na cidade de João Pessoa (PB), nas dependências da Universidade Federal da Paraíba (UFPB). Disponível originalmente em: https://dadosabertos.info/enhanced_publications/idt/. Acesso em: 25 set. 2023.

Detentor do Copyright
VI Workshop de Informação, Dados e Tecnologia - WIDaT 2023
Reconhecimento de entidades nomeadas em relatórios de inteligência financeira
Authors: Santana Jairo , Môro Diefferson K. , Silva Rogério de Aquino , Ramos Vinicius F. C. , Araújo Gustavo Medeiros de
Published: October 2023

O reconhecimento de entidades nomeadas é uma das subáreas do processamento de linguagem natural, mineração de textos e aprendizado de máquinas. Todas essas áreas fazem parte da grande área da inteligência artificial, muito utilizada em diversos problemas práticos do nosso dia a dia. Uma das competências da Polícia Federal é a investigação de crimes financeiros, em especial, a lavagem de dinheiro. Dentre os problemas encontrados na investigação policial, destacamos a análise dos Relatórios de Inteligência Financeira (RIF), escritos em português do Brasil, que são gerados pelo Conselho de Controle de Atividades Financeiras. O objetivo desta análise é identificar os atores envolvidos em esquemas de lavagem de dinheiro, mas, dependendo da complexidade do esquema, a identificação, por exemplo, desses atores e suas relações (sociedades, parentescos, “laranjas”, empresas “fantasmas”, etc) em um relatório, pode demandar um tempo significativo do policial envolvido na investigação. Este trabalho, portanto, visa apresentar resultados iniciais da automatização do reconhecimento de entidades nomeadas, importantes para a investigação policial, em RIFs. Identificamos, na literatura, uma grande lacuna para esse tipo de solução em textos em português. Os nossos resultados, ainda preliminares, demonstram que as ferramentas e os dados utilizados para o treinamento ainda precisam ser melhor trabalhados para que estes sejam mais significativos. Pudemos perceber que com poucos dados de treinamento conseguimos aumentar a precisão do reconhecimento de entidades de 14 para 27% e, em um teste com o framework RASA NLU, aumentamos a precisão para 60,98% de entidades reconhecidas corretamente, muito aquém dos 90% encontrados na literatura para outros idiomas.

Artigo apresentado no II WIDaT, em 2018, na UFPB. Disponível originalmente em: https://dadosabertos.info/enhanced_publications/idt/. Acesso em: 25 set. 2023.
Dance Studio/Clearing Conversations
Authors: Chrysa Parkinson and Frank Bock  , Olof Halldin  , Chrysa Parkinson
Published: October 2023

Conversations with dance knowledge” is a development work by Chrysa Parkinson, Professor of Dance, and Frank Bock, Senior Lecturer in Choreography, and Andrew Hardwidge.
The research is a conversation format that prioritizes movement between textures, atmospheres, qualities, and metaphors to express meaning and knowledge. By balancing somatic experience and language-based exchanges the research prioritizes nuances that emerge between people, places and things in activated space and time. The research is experimenting with question formation, spatial contexts and using simple materials in conversation. The process is documented by objects, texts, drawings, and audio files.
The aim of the research has been to develop research methods that can emphasize the authorship, materials and processes of dance and dancers within social and aesthetic discourses of dance and art practices and have direct applications in teaching processes.
Delay margin analysis of uncertain linear control systems using probabilistic µ
Authors: Somers F. , Roos Clement , Biannic Jean-Marc , Sanfedino F. , Preda Valentin , Bennani S. , Evain H.
Published: October 2023

Monte Carlo simulations have long been a widely used method in the
industry for control system validation. They provide an accurate
probability measure for sufficiently frequent phenomena, but are often
time-consuming and may fail to detect very rare events. Conversely,
deterministic techniques such as µ or IQC-based analysis allow
fast calculation of worst-case stability margins and performance levels,
but in the absence of a probabilistic framework, a control system may be
invalidated on the basis of extremely rare events. Probabilistic
µ-analysis has therefore been studied since the 1990s to bridge
this analysis gap by focusing on rare but nonetheless possible
situations that may threaten system integrity. The solution adopted in
this paper implements a branch-and-bound algorithm to explore the whole
uncertainty domain by dividing it into smaller and smaller subsets. At
each step, sufficient conditions involving µ upper bound
computations are used to check whether a given requirement – related to
the delay margin in the present case – is satisfied or violated on the
whole considered subset. Guaranteed bounds on the exact probability of
delay margin satisfaction or violation are then obtained, based on the
probability distributions of the uncertain parameters. The difficulty
here arises from the exponential term classically used to represent a
delay, which must be replaced by a rational expression to fit into the
Linear Fractional Representation (LFR) framework imposed by
µ-analysis. Two different approaches are proposed and compared in
this paper. First, an equivalent representation using a rational
function of degree 2 with the same gain and phase as the real delay,
which results into an LFR with frequency-dependent uncertainty bounds.
Then, a Padé approximation, whose order should be chosen carefully to
handle the trade-off between conservatism and complexity. A constructive
way to derive minimal LFR from Padé approximations of any order is also
provided as an additional contribution. The whole method is first
assessed on a simple satellite benchmark, and its applicability to
realistic problems involving a larger number of states and uncertainties
is then demonstrated.
Environmental and landscape genomics of Picea sitchensis (Sitka spruce) reveals clusters of loci involved with both resistance to wintering and increases in height.
Authors: Byrne Tomas , Farrelly Niall , Kelleher Colin , Hodkinson Trevor , Byrne Stephen , Barth Susanne
Published: October 2023

Picea sitchensis (Sitka spruce) occupies a large number of host
environments across the Pacific Northwest, stretching from California to
Alaska. Populations have become locally adapted to their environmental
niche rather than undergoing speciation and these local adaptions can be
discovered and utilised for breeding programs. These local adaptions may
contain traits which can confer increased resilience against climate
change. Here we employed Genome Wide Association Studies (GWAS),
Genotype Environment Analysis (GEA) and Canonical correlation analysis
to discover adaptive loci. A total of 593 adaptive loci were discovered
from the GEA. The GWAS found eight loci involved with height and one
with diameter at breast height. The canonical correlation analysis
allowed for the discovery of positive and negative correlated loci with
traits or environmental variables. We discovered 121 loci positively
correlated with environmental values and 10 loci positively correlated
with phenotypic traits. We discovered one cluster of adaptive loci
involved with snowy winter conditions and two clusters showing
adaptation to southern locations characterised with milder conditions.
The allelic distribution of positive and negatively correlated loci
involved with height showed a north south divide with loci positively
correlated with height being distributed below a latitude of 50oN. This
shows adaptations for height are generally found south of the 50th
latitude. We have discovered signs of local adaptation, with Minor
Allele Frequency (MAF) differing between northern and southern
populations.
Variation in gene expression patterns across a conifer hybrid zone highlights the architecture of adaptive evolution under novel selective pressures
Authors: Menon Mitra , Swenson Jared , Moler Ehren , Waring Kristen , Whipple Amy , Eckert Andrew
Published: October 2023

Natural plant populations often exhibit marked differences in gene
expression patterns that can reflect heterogeneity in selective
pressures. Analyzing gene expression as a quantitative trait provides a
unique opportunity to evaluate the underlying genomic basis of a
plethora of traits and their interactions in driving adaptive evolution.
We investigated patterns and processes driving expression
differentiation under conditions mimicking future climates by combining
common garden experiments with transcriptome-wide datasets obtained from
hybrid populations of Pinus strobiformis and P. flexilis. We found
strong signals of genotype-environment interactions (GEI) at the
individual transcript and the co-expression module levels suggesting a
marked influence of drought related variables on adaptive evolution.
Overall, survival was positively associated with P. flexilis ancestry,
but it exhibited an environment-specific pattern. Co-expression modules
exhibiting strong associations with survival and genomic ancestry were
representative of similar functional categories across both gardens.
Using network topology measures, putatively adaptive garden-specific
expression traits were pleiotropic and belonged to modules exhibiting
high population differentiation yet low preservation across gardens.
Overall, our study suggests the presence of substantial genetic
variation underlying univariate and multivariate traits in novel
climates that may enable populations of long-lived forest trees to
respond to rapid shifts in climatic conditions in early seedling stages
when mortality tends to be the highest. Our finding of pleiotropic trait
architectures underlying adaptive traits, however, implies rapid
adaptive responses to changing selection pressures depend on whether
trait covariances align with the direction of change in selection
pressures.
Age-related histological and ultrastructural features of the tongue of the Mallard domestic duck, Anas platyrhynchos f. domestica, Anatidae (Linnaeus, 1758) in different two age stages (post-hatching and adult) captured from Egypt
Authors: nahass eman el , Elwan Mona M.
Published: October 2023

The domestic duck is classified as a specialist filter-feeder bird
living in the water. These birds also use grazing and pecking as
terrestrial feeding methods. The tongues of domestic ducks, similar to
those of other Anseriformes, exhibit numerous types and shapes of
mechanical papillae that serve a number of purposes when collecting
food. Purpose: The current study attempts to describe the
morphological characteristics of the tongue as well as the mechanical
papillae’s development. In addition, the study aims to determine whether
the papillae observed post-hatching exhibit similar morphology to those
found in adult avian species, as well as to investigate the readiness of
the tongue to fulfill its feeding function following hatching. The
comprehensive examination of lingual mucosa is examined about the
structural modifications necessary for this variety of feeding
activities. Methods: In this study, the tongues of nine young
and adult females were used. Results: The tongue had three
distinct parts: the apex, which had a lingual nail on its ventral
surface; the body, which exhibits numerous small and large conical
papillae on its lateral sides and a lingual prominence in the caudal
region; and the root, which is covered with numerous conical papillae of
varying sizes. Conical, filiform, and hair-like mechanical papillae, the
three types of food filtration apparatus, are present in both stages.
The intra-oral transfer involves several structures, including the
median groove, lingual combs, and the rostral border of the lingual
prominence. The rostral border of the lingual prominence is
characterized by distinct rows of conical papillae. The histological
analysis demonstrated the presence of both keratinized and
non-keratinized epithelium on different tongue regions. The lingual
salivary glands in the rostral and caudal lingual salivary glands
exhibit a pronounced periodic acid–Schiff (PAS)-positive reaction.
Additionally, the yellow adipose tissue and sensory receptors, namely
the Grandry and Herbst corpuscles, which collectively form the
bill-tongue organ that monitors the movement of food. Research
highlights, these results conclude the presence of microstructural
species-specific alterations in specific tongue areas of domestic ducks’
lingual mucosa. These modifications are formed by the filtering
mechanism and terrestrial feeding mechanisms such as grazing or pecking.
Following hatching, the tongue of the domestic duck undergoes
significant development, primarily in preparation for grazing
activities. The anatomical and histological structure of the young
tongue exhibited similarities to that of the adult domestic duck while
also displaying certain variations that could potentially be attributed
to the bird’s habitat and mode of feeding.
Design and Synthesis of [2.2]Paracyclophane-based Oxazole-Pyrimidine Ligands and Application in Nickel-Catalyzed 1,2-Reduction of α,β-Unsaturated Ketones
Authors: Wang Juan , Xie Qing-Xian , Li Xiang , Yu Chang-Bin , Zhou Yong-Gui
Published: October 2023

The [2.2]paracyclophane-derived oxazole-pyrimidine ligands with
planar chirality (PYMCOX) were designed, synthesized and successfully
applied in nickel-catalyzed asymmetric 1,2-reduction of α,β-unsaturated
ketones, affording the chiral allylic alcohols with up to 99% yield and
99% ee. Meanwhile, this reduction reaction could be conducted on
gram-scale without loss of activity and enantioselectivity, and the
chiral ligand could be conveniently recovered with high yield.
Rapid and Robust Bacterial Species Identification Using Hyperspectral Microscopy and Gram Staining Techniques
Authors: Zhu Siqi , Zhou Yanzhong , li jieming , Li Zhen , Yin Hao , Chen Zhenqiang
Published: October 2023

Gram staining can classify bacterial species into two large groups based
on cell wall differences. Our study revealed that within the same Gram
group (Gram-positive or Gram-negative), subtle cell wall variations can
alter staining outcomes, with the peptidoglycan layer and lipid content
significantly influencing this effect. Thus, bacteria within the same
group can also be differentiated by their spectra. Using hyperspectral
microscopy, we identified six species of intestinal bacteria with 98.1%
accuracy. Our study also demonstrated that selecting the right spectral
band and background calibration can enhance the model’s robustness and
facilitate precise identification of varying sample batches. This method
is suitable for analyzing bacterial community pathologies.
The underlying difference of metastatic and benign cancer cells in configuring the fibre matrix to promote migration by long-distance cell mechanics
Authors: Ouyang Mingxing , Chen Weihui , Zhou Ting , Luo Teng , Zhu Chenyan , Yan Lingyun , Liu Lei , Bu Bing , Deng Linhong
Published: October 2023

The progression of tumors is heavily influenced by mechanical properties
of their microenvironment. In this work, we designed micropatterned
models with varying distances and shapes to investigate the differences
between metastatic breast cancer cells MDA-MB-231 and non-metastatic
MCF-7 in reconfiguring the extracellular matrix to promote cell
migration induced by long-distance cell mechanics. Both cancer cells
were able to rearrange type I collagen fibres to form collagen threads,
in which MDA-MB-231 consistently migrated more rapidly than MCF-7,
ranging from matrix model with differently arrayed spacings to complex
polygonal models. MDA-MB-231 displayed higher capability of reorganizing
fibre bundles at longer distance (800 μm). Further looking for
differences in cellular mechanical mechanisms, siRNA knockdown
inhibiting either integrin β1 or Piezo1 decreased fibre assembly.
Metastatic MDA-MB-231 showed inhibited migration with integrin
knockdown, whereas scattered migration with Piezo1 knockdown indicating
cells losing distant mechanosensation. MCF-7 with reduced E-cadherin by
siRNA transfection showed less significant differences in migration
compared to MDA-MB-231 that didn’t express E-cadherin. MDA-MB-231
expressed little E-cadherin mRNA indicating mutagenetic change in
genome. In summary this work has explored the differences between
malignant and benign breast cancer cells, particularly in terms of fibre
matrix remodelling and cell migrations, along with significant
differences in E-cadherin expressions, of which had an important effect
on cell migration. The results of this study provide new research
approaches for therapeutic advances in breast cancer.
From Taboo to Treatment: The Emergence of Psychedelics in the Management of Pain and Opioid Use Disorder
Authors: Weleff Jeremy , Nunes Julio , Costa Gabriel , Sofuoglu Mehmet , Maclean Ross , Aquino Joao De
Published: October 2023

The rise of psychedelics in contemporary medicine has sparked interest
in their potential therapeutic applications. While traditionally
associated with countercultural movements and recreational use, recent
research has shed light on the potential benefits of psychedelics in
various mental health conditions. In this review, we explore the
emerging role of psychedelics in the management of chronic pain and
opioid use disorder (OUD), two critical areas in need of innovative
treatment options. Pain control remains a significant clinical
challenge, particularly for individuals with OUD and those who receive
long-term opioid therapy (LTOT) who develop marked tolerance to
opioid-induced analgesia. Despite the magnitude of this problem, there
is a scarcity of controlled studies investigating pain management
alternatives for these populations. Drawing from preclinical and human
evidence, we highlight the potential of psychedelics to act on shared
neurobiological substrates of chronic pain and opioid use disorder,
potentially reversing pain- and opioid-induced neuroadaptations, such as
central sensitization. We elaborate on the multifaceted dimensions of
the pain experience (sensory, affective, and cognitive) and their
intersections that overlap with opioid-related phenomena (opioid craving
and withdrawal), hypothesizing how these processes can be modulated by
psychedelics. After summarizing the available clinical research, we
propose mechanistic insights and methodological considerations for the
design of future translational studies and clinical trials, building on
a shared clinical and neurobiological understanding of chronic pain and
OUD. Our intention is to provide timely perspectives that accelerate the
development and exploration of novel therapeutics for chronic pain and
OUD amidst the escalating opioid crisis.
Triclosan Allergy Mimicking Recurrent CIED Infections
Authors: Crossley George H. , Kowal Jamie , Bloch Karen , Phillips Jane , Kawash Basil
Published: October 2023

An 80-year-old man had a secondary prevention defibrillator in place for
treatment of sustained ventricular tachycardia. After a generator
replacement several years later, he developed a series of apparent pulse
generator infections requiring extraction. Each purulent appearing
pocket eruption was culture negative. Eventually, he was diagnosed with
a delayed hypersensitivity reaction to triclosan, an antibacterial that
is commonly impregnated in surgical sutures. The evaluation for this is
difficult and can be misleading. This entity should be considered in the
differential diagnosis of patients with culture negative CIED
infections.
Non-destructive seed phenotyping and time resolved germination testing using X-ray
Authors: Claussen Joelle , Wolff Antje , Rehak Markus , Wolff Johannes , Eerdt Bas van , Gerth Stefan
Published: October 2023

Current phenotyping technologies, whether based on cameras, LIDAR or
hyperspectral imaging, are capturing mainly 3D surfaces and are limited,
to penetrate into growth media and internal tissue and structures. 3D
X-ray computed tomography (CT) alleviates many of these shortfalls by
enabling a non-destructiv visualization of optically inaccessible plant
structures, allowing for the 3D reconstruction and measurement of
objects at high resolution and high throughput. We will present a range
of fully automated, industrially validated 3D X-ray CT based
technologies, that enable to visually and quantitively follow up in 4D
the entire plant development cycle from flowers/ears to seeds to
germinating seedling in filter paper to plants and root structures in
soil. We will emphasize the non-destructive fully-automated 3D
phenotyping of seeds and the resulting germinating seedlings including
their internal organs in filter paper across time, i.e. in 4D, at a
current throughput of 200 seeds/min and 25 seedlings/min, respectively.

The presented technologies, being universally applicable across plant
and crop species, allow for the quantitative, objective and reproducible
assessment of morphological seed and seedling traits in 4D. They provide
powerful tools to investigate any influence, whether genetic,
environmental or treatment-related on seed quality and the germination
capacity, vigor and 3D phenotype of the resulting seedling over large
samples as big data. We will present the technologies and data on traits
such as seed quality, seedling development, degree of abnormalities,
germination capacity and vigor across different crop types.
DIY image analytics for UAS-based plant phenotyping
Authors: Kim James
Published: October 2023

UAS-based image analytics has been deployed to expedite the plant
phenotyping and replace laborious manual notetaking but is limited for
global validation in all field conditions. Plot-level metrics is
essential for plant phenotyping on many plots and extracted by defining
a region of interest (ROI) of the field boundary and processing sub-ROIs
aligned with rows and columns of the total number of plots, called
gridding. Gridding is offered by commercial software but is limited to
upright rectangular fields. When UAS tile images are stitched, an
orthomosaic image is georeferenced to make the image top to north,
whereas the field orientation is often off the north. Due to the
misaligned orientation, the gridding process requires a preprocess of
image rotation to align the grid onto the field boundary, which creates
resampling errors and takes laborious multiple adjustments to precisely
align sub-ROIs with plots across the field. To address this issue, an
open-source software was developed to generalize the gridding method and
provide a quick extraction of plot-level metrics without the image
rotation. Adaptive gridding algorithm is to rotate the grid by applying
geometry of a rectangle in a circle that keeps right angles. Metrics of
the rotated ROI is calculated by geofencing pixels in the ROI for
segmentation, filtering, masking, and clustering. The open-source
software with adaptive gridding allows the end-users to process their
UAS images for high throughput phenotyping in an effective manner
without understanding details of image processing.
Automated high throughput plant phenotyping to assess sunflower planting dates
Authors: Mbere Tshegofatso , Swanevelder Dirk , Pierneef Rian , Creux Nicky
Published: October 2023

South Africa is dependent on dryland farming, causing crops to be sown
only once the rainy season begins. With climate change altering weather
patterns, unpredictable rainy seasons may lead to cash crops such as
maize and soybean being planted later, which makes them susceptible to
extreme temperatures and drought. Farmers often switch to planting
sunflower (Helianthus anuus L.) under these conditions because of
its shorter rotation time and hardier nature. For this reason, sunflower
tends to be planted outside of its optimal planting window. To
understand the effects of different planting dates on sunflower growth
and development, a planting date trial was established in Potchefstroom
under the Phenospex FieldScan system. Low-and high-density monthly
plantings were sown from October to March and scanned three times a day
(RGB, NIR, Laser). Values are extracted to calculate plant growth and
health indices over the season for each planting date. The aim of this
project is to develop a Shiny application that can analyse the Phenospex
data outside of the platform. Phenospex software is expensive and
impractical to use in the South African context with unstable
infrastructure because it requires the sever to be on in one location
for analysis in a different location. The Shiny app will allow Phenospex
data to be analysed offline, offering more flexibility in an African
setting.