bluuebunny/crossref_metadata_2025 huggingface dataset:
Simultaneous inhibition of Sirtuin 3 and cholesterol homeostasis targets acute myeloid leukemia stem cells by perturbing fatty acid β-oxidation and inducing lipotoxicity
Authors: O’Brien Cristiana , Ling Tianyi , Berman Jacob M. , Culp-Hill Rachel , Reisz Julie A. , Rondeau Vincent , Jahangiri Soheil , St-Germain Jonathan , Macwan Vinitha , Astori Audrey , Zeng Andy , Hong Jun Young , Li Meng , Yang Min , Jana Sadhan , Gamboni Fabia , Tsao Emily , Liu Weiyi , Dick John E. , Lin Hening , Melnick Ari , Tikhonova Anastasia , Arruda Andrea , Minden Mark D. , Raught Brian , D'Alessandro Angelo , Jones Courtney L.
Published: April 2023

Outcomes for patients with acute myeloid leukemia (AML) remain poor due to the inability of current therapeutic regimens to fully eradicate disease initiating leukemia stem cells (LSCs). Previous studies have demonstrated that oxidative phosphorylation (OXPHOS) is an essential process that is targetable in LSCs. Sirtuin 3 (SIRT3), a mitochondrial deacetylase with a multi-faceted role in metabolic regulation, has been shown to regulate OXPHOS in cancer models; however, it has not yet been studied in the context of LSCs. Thus, we sought to identify if SIRT3 is important for LSC function. Using RNAi and a SIRT3 inhibitor (YC8-02), we demonstrate that SIRT3 is a critical target for the survival of primary human LSCs but is not essential for normal human hematopoietic stem and progenitor cell (HSPC) function. To elucidate the molecular mechanisms by which SIRT3 is essential in LSCs we combined transcriptomic, proteomic, and lipidomic approaches, showing that SIRT3 is important for LSC function through the regulation of fatty acid oxidation (FAO) which is required to support oxidative phosphorylation and ATP production in human LSCs. Further, we discovered two approaches to further sensitize LSCs to SIRT3 inhibition. First, we found that LSCs tolerate the toxic effects of fatty acid accumulation induced by SIRT3 inhibition by upregulating cholesterol esterification. Disruption of cholesterol homeostasis sensitizes LSCs to YC8-02 and potentiates LSC cell death. Second, SIRT3 inhibition sensitizes LSCs to BCL-2 inhibitor venetoclax. Together, these findings establish SIRT3 as a regulator of lipid metabolism and potential therapeutic target in primitive AML cells.
On the relationship of economic complexity indices and indicators of socio-economic development
Authors: Afanasiev Mikhail
Published: April 2023

The comparison of the indices of economic complexity of regions based on data on production volumes by sector and the indices based on data on types of economic activity is carried out. The possibility of choosing the threshold value of the indicator of the identified comparative advantages RCA for assessing economic complexity, as well as for assessing the relationship of economic complexity indices and indicators of socio-economic development is analyzed. The possibility of choosing the threshold value of the indicator of the identified comparative advantages of RCA for assessing economic complexity, as well as for assessing the relationship of economic complexity indices and indicators of socio-economic development is analyzed. It is shown that at threshold 1, the index of economic complexity by sector and the index of economic complexity by type of economic activity are highly resistant to changes in the threshold and have advantages over indices constructed at other thresholds. A significant statistical dependence of the index of economic complexity, based on data on sectors at the RCA threshold 1, with a number of indicators of socio-economic development characterizing the quality of life has been established.
Literasi Informasi, Lingkungan Keluarga dan Minat Berwirausaha : Bagaimana Pengaruhnya Terhadap Perilaku Berwirausaha Siswa SMK?
Authors: Harahap Desi Sukmayanti , Sumarno Sumarno , Ayub Daeng
Published: April 2023

This study aims to analyze the causal influence of information literacy, family environment, and interest in entrepreneurship on the entrepreneurial behavior of SMK students. This research used descriptive and verification methods with a quantitative approach. The sample was students at SMK Negeri 1 Barumun, with 204 students as respondents. The research instrument used a questionnaire and an observation sheet. The data were then analyzed using multiple regression tests and path analysis. The study's findings revealed a direct relationship between information literacy and the family environment and entrepreneurship interest. Furthermore, there was a direct relationship between information literacy and a family environment conducive to entrepreneurship and entrepreneurial behavior. Through an interest in entrepreneurship, information literacy has an indirect effect on entrepreneurial behavior. Through an interest in entrepreneurship, the family environment indirectly affected entrepreneurial behavior.
The Relationship Between of Psychological Capital and School Counsellors Burnout : A Systematic Literature Review
Authors: Aniyatussaidah Aniyatussaidah , Herdi Herdi
Published: April 2023

This research aims to describe the relationship between psychological capital and school counsellors’ burnout. This research method employed a Systematic Literatur Review, collected reading material from various scientific articles (SCOPUS, EBSCO and SINTA) and subsequently compared relevant theories and research results. Based on the results of a literature study conducted, it was found that there was a significant relationship between psychological capital and school counsellors' burnout. A high state of psychological capital (hope, belief, resilience, and optimism) can provide energy for school counsellors to control behavior and reduce symptoms of burnout (fatigue, negative work environment, indifference to clients, feeling incompetent as a school counselor, and chaotic personal life). School Counsellors who have hope will have goals and know the way to achieve these goals. It makes the school counsellors able to overcome things that make theme burnout. School Counsellors will become more resilient, confident, and optimistic in carrying out their role as school counsellors.
Development of Science Learning E-Modules Using the Flip PDF Application
Authors: Nugroho Muhammad Rifqi , Sumardjoko Bambang , Fathoni Achmad
Published: April 2023

This study aims to analyze the results of the validity and the practicality of science e-modules using the flip pdf application at SMP Muhammadiyah Al-Kautsar PK. Development research was conducted using the ADDIE model. Interviews and questionnaires were used as data collection techniques. The data analysis technique used descriptive qualitative and quantitative analysis. The e-module product validation was carried out by three experts, namely subject content experts, design experts, and media experts, with an average score of 93.3%, indicating that the E-Module was in very good qualification. The practicality test was carried out using a student response questionnaire after using the e-module; an average of 93.7% was obtained with very practical criteria. The conclusion is that the science e-module developed using the flip pdf application is valid and practical.
Mediasi Komitmen Kerja pada Hubungan antara Budaya Organisasi terhadap Kinerja Guru Era Merdeka Belajar
Authors: Efendi Feriawan , Ambarwati Sri Wulan , Navion Febranti Putri
Published: April 2023

This study aims to analyze the influence of organizational culture on teacher performance, the influence of organizational culture on work commitment, the influence of work commitment on teacher performance, and the influence of organizational culture on teacher performance in the era of independent learning mediated by work commitment. This study used a survey method with a quantitative approach. The sample for this study consisted of 88 teachers from the Senior High School of the Program Sekolah Penggerak (PSP) in the Education Branch of Blitar City. The instrument used was a questionnaire distributed to respondents online through Google Forms. Then, the data were analyzed using descriptive statistics and Partial Least Squares (PLS). The results showed a positive and significant influence of organizational culture on teacher performance in the era of independent learning, a positive and significant influence of organizational culture on work commitment, no significant influence of work commitment on teacher performance in the era of independent learning, and no mediating effect of work commitment and no significant influence of organizational culture on teacher performance in the era of independent learning.
Eficiência agronômica de remineralizador granítico K6 na produção de soja e milho silagem
Authors: Brasil Eliana Paula Fernandes , Leandro Wilson Mozena , Castro João Paulo Vilela , Araújo Isadora de Lima , Lucas Pedro Marques , Araújo Thiago de Godoi
Published: April 2023

O Brasil é destaque nesse tema, pois é tido como um dos pilares da agricultura mundial. Atualmente, o país é um importante produtor e exportador de produtos agrícolas; entretanto, é altamente dependente da importação de fertilizantes e de matérias-primas não renováveis, além de sofrer com elevados custos econômicos. Logo, remineralizadores podem ser uma alternativa para a diminuição do uso de fertilizantes minerais solúveis, assim como os custos de produção. O objetivo desta pesquisa é verificar a eficiência agronômica do potencial remineralizador granítico K6 da Embu S/A Engenharia e Comércio nas culturas de soja e milho silagem em diferentes classes texturais de solo. Os tratamentos experimentais foram baseados em doses crescentes do potencial remineralizador K6, a saber: 30 kg. ha-1 de K2O de K6; 60 kg. ha-1 de K2O de K6; 120 kg. ha-1de K2O de K6; 240 kg. ha-1 de K2O de K6; tratamentos de referência: 60 kg. ha-1 de K2O do remineralizador FMX e 60 kg. ha-1 de K2O com cloreto de potássio (KCl); e tratamento testemunha, todos com quatro repetições. Dados de produtividade indicam liberação de K no solo, o qual foi absorvido pelas plantas teste; O remineralizador K6 apresenta comportamento no solo semelhante ao do FMX e, em alguns casos, ao do KCl. O potencial remineralizador granítico K6 contribui para otimizar o manejo nutricional das culturas testes deste estudo.
Percepção dos enfermeiros em relação ao tratamento da sífilis gestacional em um distrito do municipio de Curitiba-PR
Authors: Valdeira Laryane Pinheiro , Souza Marli Aparecida Rocha de , Rabelo Marcelexandra , Pereira Romulo
Published: April 2023

As infecções sexualmente transmissíveis (IST) são causadas por mais de 30 agentes etiológicos, podendo ser: vírus, bactérias, fungos e protozoários, transmitidas principalmente por contato sexual e, eventualmente, por via sanguínea. Dentre estas doenças, uma das mais comuns é a sífilis, de caráter sistêmico, curável e exclusiva do ser humano. Objetivo: Descrever as percepções dos enfermeiros em relação ao tratamento de sífilis gestacional em um distrito sanitário (DS) do município de Curitiba/PR. Método: O método teve abordagem qualitativa com caráter descritivo, no qual foram realizadas questionário semiestruturadas com 15 enfermeiros da Rede de Atenção em Saúde (RAS) em um Distrito Sanitário (DS) de Curitiba/PR, posteriormente estas foram transcritas e agrupadas em uma planilha do Microsoft Excel para o início da análise de conteúdo de Minayo, Resultados:  A análise resultou em quatro categorias destacadas como: falta de adesão ao tratamento; dificuldades encontradas na realização do protocolo; falta de conhecimento científico sobre a patologia; e realização de capacitação aos profissionais enfermeiros no tratamento da sífilis na gestação. Considerações finais: Evidenciou-se a necessidade de abordagem com estratégias em educação permanente em saúde, promovendo, além de constantes atualizações, reflexões e debates sobre os problemas levantados pelos próprios profissionais. Entre eles os desafios mais percebidos foram a insegurança e alta demanda na rotina diária do enfermeiro, o que impede a realização de protocolos específicos da categoria, entre eles o tratamento da sífilis gestacional.
Os efeitos da contrarreforma psiquiátrica na política de redução de danos no campo do álcool e outras drogas
Authors: Barbosa Ellen Inocencio , Figueiredo Karina Aparecida
Published: April 2023

Este trabalho tem como objetivo analisar os efeitos da contrarreforma psiquiátrica na política de redução de danos no campo álcool e outras drogas a partir da análise de referencial teórico sobre a temática em conjunto com as percepções constatadas a partir da vivência em um Centro de Atenção Psicossocial Álcool e Drogas, enquanto assistente social residente do Programa de Saúde Mental do Adulto da FEPESC/ESCS/SES-DF. Trata-se de um estudo descritivo, do tipo revisão literária em conjunto com o relato de experiência em um CAPS AD, em que foram analisados os desdobramentos do retrocesso político no movimento da reforma psiquiátrica que impactaram as estratégias de redução de danos no campo AD. A metodologia utilizada para a coleta de dados foi a seleção de artigos que abordavam sobre redução de danos, saúde mental e reforma psiquiátrica no contexto político, além de da utilização de registros em diário de campo do período da vivência prática no cenário em questão. As análises permitiram constatar que o avanço da agenda política conservadora, atrelada à moralização do cuidado ao usuário de substâncias psicoativas invalidaram estratégias que possuem um olhar integral à saúde mental desses indivíduos, como a estratégia de redução de danos.
Benefícios da gastrostomia em pacientes com fibrose cística
Authors: Boranga Letícia Bueno , Resende Leonardo Rodrigues
Published: April 2023

A Fibrose Cística é uma doença genética autossômica recessiva caracterizada por mutações no gene CFTR (Cystic Fibrosis Transmembrane Condutance Regulator), responsável pelo transporte de cloro através da membrana celular. Ela causa alterações nas secreções de vários órgãos tornando-as grossas e espessas, além de causar diversas alterações metabólicas no organismo do ser humano. No estado do Mato Grosso do Sul residem setenta pessoas portadoras de Fibrose Cística em tratamento no Instituto IPED APAE de Campo Grande. Dentro deste contexto, através de uma metodologia de estudo descritivo e observacional foram selecionados para coleta de dados quatro voluntários pediátricos que realizaram a gastrostomia. Estes dados foram aplicados aos exames laboratoriais, relações antropométricas e o método da Escala de Shwachman com o objetivo de avaliar os possíveis benefícios que a gastrostomia (GT) pode apresentar nesses pacientes portadores de Fibrose Cística. Após inserção da GT foi possível observar uma melhora nos perfis analisados e na qualidade de vida de cada paciente estudado, portanto, cabe ressaltar que estudos nesse campo devem ser mais difundidos para uma melhor avaliação estatística, aumentando assim amostra para futuros estudos.
Fatores de risco que desencadeiam a depressão pós-parto (DPP): uma revisão integrativa da literatura
Authors: Conrado Gilceane Maria , Paiva Claudeir Siqueira de , Silva Larissa Gabriele Farias e , Couto Sabrina Iracema da Silva
Published: April 2023

Objetivo: Descrever com base na literatura científica os principais fatores de risco que influenciam o desenvolvimento de uma depressão pós-parto. Metodologia: Trata-se de uma Revisão integrativa da literatura, realizada no mês de agosto de 2022, tendo como base de dados: BVS, SCIELO e LILACS, onde foram utilizados artigos na língua portuguesa e período entre 2016 e 2022. Resultados: Foram encontrados 684 artigos no total, após rigor metodológico por meio dos critérios de inclusão e exclusão, foram selecionados 13 artigos, sendo 5 artigos na BVS, 7 na SCIELO e 1 na LILACS, logo após criteriosa avaliação dos artigos, a análise foi feita de forma descritiva e predispõe a extração dos seguintes dados: título, objetivo, autores/ano e tipo de estudo, onde todos os artigos evidenciam os fatores de risco para desenvolver depressão pós-parto. Conclusão: Portanto, foi possível observar que tanto a gestação como o puerpério requerem cuidados especiais para prevenir e diagnosticar precocemente uma depressão pós-parto, sendo necessário reconhecer e buscar manejar da melhor forma os fatores de risco que desencadeiam a mesma, pois o período gravídico-puerperal é complexo e de vulnerabilidade para a mulher, onde as alterações multicausais advindas da combinação de características fisiológicas, psicológicas, sociais e, além da influência de fatores de risco genético e ambientais pode predispô-la ao desenvolvimento dessa doença.
O uso de imunomoduladores na alimentação de peixes: Uma revisão
Authors: Acunha Rubia Mara Gomes , Sanches Danilo de Souza , Almeida Rômulo Guilherme dos Santos , Oliveira Fúlvia Cristina , Soares Michelly Pereira , Davalo Marilda Ribeiro Soares , Silva Maria Eduarda Vasconcellos Mendes da , Oliveira Kathianne Kelli Chaves de , Campos Cristiane Meldau de
Published: April 2023

A utilização de imunoestimulantes em peixes é um método preventivo para combater infecções que frequentemente acometem os animais no ambiente produtivo, sendo uma alternativa biológica com grande potencial para minimizar o uso excessivo de antibióticos. Na aquicultura, os imunomoduladores são divididos em dois grupos, os imunonutrientes (vitaminas, minerais e aminoácidos) e os imunoestimulantes não nutricionais (óleos essenciais, extratos de plantas, fitoterápicos, prebióticos, probióticos e simbióticos), sendo estes últimos, muito estudados atualmente. Ambas alternativas objetivam maximizar o desempenho, reduzir o estresse, melhorar a saúde do trato gastrointestinal e, consequentemente, a imunidade e resistência às doenças dos peixes. Assim, com a presente revisão de literatura os objetivos são abordar os diferentes imunomoduladores utilizados na piscicultura, dando ênfase ao mecanismo de ação no organismo e níveis de inclusão, bem como ressaltar resultados de estudos realizados com diferentes espécies produzidas em sistema intensivo em larga escala.
Assistência de enfermagem durante o processo de hemotransfusão em pacientes oncológicos: revisão integrativa
Authors: Frazão Janice de Matos , Melo Edjane Marcia Linhares , Santana Mary Elizabeth de
Published: April 2023

Esta pesquisa tem como objetivo identificar na literatura sobre a assistência de enfermagem durante o processo de hemotransfusão em pacientes oncológicos. Trata-se de uma revisão integrativa da literatura, com abordagem exploratória descritiva de cunho qualitativa. Norteada pela pergunta de pesquisa: Quais as evidências sobre os cuidados de enfermagem em hemotransfusão a pacientes oncológicos? A busca aconteceu nas bases de dados que são as seguintes: Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS), Medical Literature, Analysis and Retrieval System Online (MEDLINE), Cochrane Central Register of Controlled Trials da Cochrane Biblioteca e na Base de dados de Enfermagem (BDENF) e Scientific Electronic Library Online (SCIELO). Realizada entre o período de 2016 a 2021. Foram selecionadas dezessete produções cientificas para compor essa revisão da literatura. A análise crítica dos estudos possibilitou a elaboração e duas categorias para discussão dos resultados. Categoria 1- Assistência de Enfermagem; Categoria 2- Tecnologia educativa para mediar o cuidado de enfermagem durante o processo de hemotransfusão em pacientes oncológicos. De acordo com a revisão da literatura identificou-se como a assistência de enfermagem aos pacientes oncológicos durante a hemotransfusão vem sendo realizada nas instituições de saúde e discutiu-se sobre a necessidade da utilização de tecnologias educativas durante o processo de hemotransfusão em pacientes hospitalizados.
Adaptação e validação do conteúdo da escala de utilização das tecnologias digitais na gestão escolar
Authors: Gonçalves Antoniel Borges , Pedro Neuza
Published: April 2023

Objetivo: traduzir, adaptar e validar o conteúdo da escala de utilização das tecnologias na gestão escolar do contexto da língua portuguesa europeia para contexto da língua portuguesa brasileira. Metodologia: o processo metodológico foi orientado na seguinte ordem: i) obtenção de autorização para adaptação da escala; ii) tradução da escala da língua portuguesa europeia para a língua portuguesa brasileira, iii) adaptação por consenso do conteúdo das traduções, iv) validação do conteúdo adaptado, optando-se pela validação por 3 juízes especialistas no tema e contexto do estudo.  através da aplicação do Coeficiente de Validade de Conteúdo (CVC), v) concordância dos autores da escala, quanto a versão final desenvolvida da escala. Resultados: a média do CVC dos 3 especialistas avaliadores, subtraído como um todo pelo Erro Padrão (Pe) da polarização dos avaliadores foi de 0,98. Em relação a Concordância dos itens, o valor do CVCt foi 1.0. A Coerência dos itens apresentou valor do CVCt de 1.0. Objetividade dos itens registou-se um valor de CVCt de 1.0. Na Pertinência dos itens, o valor do CVCt foi de 0.9. No parâmetro Adequação do Conteúdo dos itens, registou-se um valor de CVCt de 1.0. Conclusão: o objetivo deste estudo foi alcançado com êxito considerando que a média obtida do CVC, por parte dos 3 especialistas avaliadores, foi de 0,98. Considerando-se a indicação da literatura, quão mais próximo de 1.0 for o CVCt, maior é a confiança do conteúdo.
Dimensões que gerenciam os recursos humanos de forma sustentável entrega melhores resultados
Authors: Tavares Luiz Fernando , Costa Neto Pedro Luiz de Oliveira
Published: April 2023

Gerenciar o departamento recursos humanos com foco nas estratégias da empresa, significa ser o intermediário entre os departamentos, contribuir para a satisfação dos clientes, mediante a atuação de melhores colaboradores por serem estes objeto de melhor atenção por parte da empresa por trabalhar quando podem se melhor desenvolver profissionalmente, o que se consegui conforme discutido no presente artigo através do equilíbrio entre as três dimensões para obter a colaboração de bons profissionais que são atrair, reter e desenvolver essas pessoal, atrair significa fazer a empresa desejada por seus futuros colaboradores, reter é manter seu capital humano, através de técnicas motivacionais e avaliando sua satisfação, desenvolver é ter a capacidade de cuidar do futuro de seus colaboradores proporcionando-lhes as condições para o aperfeiçoamento profissional. Quando uma empresa consegui equilibrar essas duas vertentes através das três dimensões pode-se afirmar que a empresa é sustentável organizacionalmente, o artigo também considera o comprometimento do colaborador.
Importância da educação em direitos humanos
Authors: Santos Douglas Vargas dos , Claudino Wendel Oroski , Gonçalves Roberto Leonardo , Puerari Rodrigo , Pola Paula dos Santos
Published: April 2023

As crianças e jovens devem ter acesso à educação em direitos humanos (EDH) e que as escolas são um dos principais meios pelos quais a EDH deve ser disponibilizada. No entanto, atualmente há conhecimento limitado sobre a presença e a forma de EDH em contextos escolares, e não há meios estabelecidos através dos quais a oferta de EDH nas escolas seja avaliada. Este artigo propõe uma estrutura teórica para apoiar a classificação das responsabilidades do ensino em relação à EDH e argumenta que é necessária uma mudança sistêmica nos sistemas educacionais para que a oferta de EDH seja realizada de maneira mais ampla e consistente.  A viabilidade da estrutura desenvolvida foi então testada aplicando-a aos resultados dessas análises. A contribuição teórica feita pelo documento aprofunda o conhecimento e a compreensão sobre a natureza das responsabilidades atribuídas aos professores para educar os alunos sobre os direitos humanos e fornece uma base para estimular o debate sobre o que constitui práticas efetivas de EDH escolar.
Avaliação fitoquímica de extratos das folhas de Eugenia uniflora L.
Authors: Waiss Zanusso Paula , Albano Mariño Patrícia , Maldaner Graciela , Gonçalves Rafael Pintos
Published: April 2023

A Eugenia uniflora L., família Myrtaceae, é conhecida popularmente como pitanga (o fruto) e pitangueira, a árvore. Condições externas e internas são citadas como interferentes no conteúdo final de metabólitos secundários nas plantas medicinais. Este trabalho objetivou realizar o screening fitoquímico quali e quantitativo de diferentes extratos das folhas de Eugenia uniflora L. O material vegetal foi coletada no município Bagé/RS em fevereiro de 2021. As análises fitoquímica qualitativas foram realizadas através de reações clássicas de caracterização empregadas em farmacognosia. Para a análise quantitativa foram obtidos três extratos empregando diferentes formas de preparo: infuso e decocto aquoso e macerado etanólico 93%, todos com concentração de 5% (p/v). O teor de polifenóis foi determinado pelo método de Folin-Ciocalteau e o doseamento de flavonoides totais foi realizado de acordo com a metodologia descrita na Farmacopéia Brasileira IV por espectofotometria. Foram identificados qualitativamente os metabólitos flavonoides, alcaloides, taninos e saponinas. Apenas os glicosídeos cardiotônicos apresentaram resultado negativo. Foi verificado ainda a presença de taninos hidrolisáveis. Entre os extratos testados, o infuso aquoso demonstrou menores valores aos demais tanto no doseamento de polifenóis (5,91 µg/g; decocto 10,69 µg/g e macerado 10,02 µg/g) quanto de flavonóides totais (0,47 mg/g; decocto 1,19 mg/g e macerado 2,59 mg/g) inclusive com variação estatística. Os resultados confirmam a influência de fatores internos (método de extração e solventes empregados) e externos na produção de metabólitos secundários das plantas. Supõe-se que a presença de taninos hidrolisáveis pode estar relacionada ao grande volume de chuva ocorrido.
O cuidado do pai ao prematuro: uma revisão integrativa
Authors: Vaz Jéssica Cardoso , Milbrath Viviane Marten , Gabatz Ruth Irmgard Bärtschi , Hense Tuize Damé
Published: April 2023

Objetivo: Conhecer o que tem sido publicado sobre o cuidado do pai ao recém-nascido prematuro. Materiais e método: Trata-se de uma revisão integrativa realizada nas bases de dados Literatura Latino Americana e do Caribe em Ciências da Saúde, Centro Latino-Americano e Sistema Online de Busca e Análise de Literatura Médica e Cochrane Library, sem limite temporal, nos idiomas português, inglês e espanhol, a fim de ter maior abrangência das publicações. Foram selecionados ao total 62 estudos para compor esta revisão. Resultados: Com base nos achados, foram elaborados três temas: Hospitalização do Recém-Nascido Prematuro na Unidade de Terapia Intensiva Neonatal; Adaptação inicial e participação dos pais e mães nos cuidados prestados ao Recém-Nascido Prematuro; e Mudanças na rotina familiar decorrentes do nascimento prematuro. Conclusões: é preciso repensar o modelo tradicional de assistência ao recém-nascido embasado predominantemente na participação materna, devendo os profissionais de saúde incorporar a presença do pai nas unidades neonatais, visando implementar medidas para definir e garantir seu efetivo papel no cuidado do filho.
The Relationship of Economic Growth, Export Value and Inflation with The Autoregressive Distributed Lag (ArDL) Approach
Authors: Fitriyanto Nur
Published: April 2023

Economic growth is one of the benchmarks for the success of a country in running the economy along with the factors that influence it, so this is important to observe. Many previous studies have proven the influence of export value and inflation on economic growth. This study chooses the Autoregressive Distributed Lag (ARDL) model approach to see the dynamics of long-term and short-term relationships for the variables of export value, inflation and economic growth. The research period is quarterly, starting from 2011:Q1 – 2019:Q4 with the type of time series data. The results of this study, through the ARDL model, the variables of export value and inflation are proven to have long-term cointegration or move together in the long term towards economic growth. This study also succeeded in revealing that the variables of export value and inflation have a short-term relationship with a relatively fast adjustment time, which is 2-3 months to return to balance. Keywords:ArDL, export value, economics growth
The Conversions of C.S. Lewis: Notes on Rethinking Their Chronology and Character
Authors: Johnston William H.
Published: April 2023

This essay seeks to contribute to ongoing study of the chronology and characteristics of C.S. Lewis's multi-step conversion to Christianity by inviting new consideration of features of three moments or phases of that process. Section 1 proposes adding ‘conversion to conscience’ in early 1930 as an identifiable phase in the process. Section 2 enters discussion of the dating of Lewis's conversion to theism in June or July of 1930 and its relation to his learning to dive, with attention to the emotional intensity of that conversion. Section 3 re-reads Lewis's explanations of his conversion to Christianity in the autumn of 1931, noting the extended time it took and the nature of his hesitancies before full commitment.
Functional septorhinoplasty alters brain structure and function: Neuroanatomical correlates of olfactory dysfunction
Authors: Whitcroft Katherine L. , Mancini Laura , Yousry Tarek , Hummel Thomas , Andrews Peter J.
Published: April 2023

Introduction

We previously demonstrated functionally significant structural plasticity within the central olfactory networks, in association with improved olfaction after surgical treatment of chronic rhinosinusitis (CRS). In order to confirm and expand on these findings, the primary aim of this study was to determine whether these same regions undergo functionally significant structural plasticity following functional septorhinoplasty (fSRP), in patients with non-CRS olfactory dysfunction (OD) of mixed cause. fSRP has previously been shown to improve olfactory function, and the secondary aim of this study was to provide initial insights into the mechanism by which fSRP affects olfaction.

Methods

We performed a pilot prospective, multimodal neuroimaging study in 20 participants undergoing fSRP, including patients with non-CRS OD of mixed cause, as well as normosmic surgical controls. Participants underwent psychophysical olfactory testing, assessment of nasal airway, structural and functional neuroimaging. This was performed pre- and postoperatively in patients, and preoperatively in controls.

Results

There was a statistically and clinically significant improvement in mean psychophysical olfactory scores after surgery. This was associated with structural and functional plasticity within areas of the central olfactory network (anterior cingulate, orbitofrontal cortex, insula, temporal pole). Improved psychophysical scores were significantly correlated with change in bilateral measures of nasal airflow, not measures of airflow symmetry, suggesting that improved overall airflow was more important than correction of septal deviation.

Conclusion

This work highlights the importance of these neuroanatomical regions as potential structural correlates of olfactory function and dysfunction. Our results also provide initial insight into the mechanistic effects of fSRP on olfaction. Further work could investigate the utility of these regions as personalised biomarkers of OD, as well as the role of fSRP in treating OD.
Saccharomyces cerevisiae surface display of endolysin LysKB317 for control of bacterial contamination in corn ethanol fermentations
Authors: Lu Shao-Yeh , Liu Siqing , Patel Maulik H. , Glenzinski Kristina M. , Skory Christopher D.
Published: April 2023

Control of bacterial contamination in bioethanol fermentation facilities has traditionally relied on chemical-based products such as hop acids and use of antibiotics. Recent emphasis on antibiotic stewardship has prompted new research into the development of alternative approaches to microbial remediation strategies. We recently described a recombinant peptidoglycan hydrolase, endolysin LysKB317, which inhibited Limosilactobacillus fermentum strains in corn mash fermentation. Here, Saccharomyces cerevisiae EBY100 was used to anchor recombinant LysKB317 using cell surface display with the a-agglutinin proteins Aga1p–Aga2p. Immunostaining and confocal fluorescence were used for localization of the extracellular interface of the cells. Yeast surface-expressed endolysin demonstrated an 83.8% decrease in bacterial cell counts compared to a 9.5% decrease in control yeast. Recombinant S. cerevisiae expressing LysKB317 used for small-scale corn mash fermentation, when infected with L. fermentum, could proactively control bacterial infection for 72 h with at least 1-log fold reduction. Analysis of fermentation products showed improved ethanol concentrations from 3.4% to at least 5.9% compared to the infection-only control and reduced levels of lactic and acetic acid from 34.7 mM to 13.8 mM and 25.5 mM to 18.1 mM, respectively. In an optimized yeast surface display system, proactive treatment of bacterial contaminants by endolysin LysKB317 can improve fermentation efficiency in the presence of L. fermentum contamination.
Patterning of the Drosophila retina by the morphogenetic furrow
Authors: Warren Jasmine , Kumar Justin P.
Published: April 2023

Pattern formation is the process by which cells within a homogeneous epithelial sheet acquire distinctive fates depending upon their relative spatial position to each other. Several proposals, starting with Alan Turing’s diffusion-reaction model, have been put forth over the last 70 years to describe how periodic patterns like those of vertebrate somites and skin hairs, mammalian molars, fish scales, and avian feather buds emerge during development. One of the best experimental systems for testing said models and identifying the gene regulatory networks that control pattern formation is the compound eye of the fruit fly, Drosophila melanogaster. Its cellular morphogenesis has been extensively studied for more than a century and hundreds of mutants that affect its development have been isolated. In this review we will focus on the morphogenetic furrow, a wave of differentiation that takes an initially homogeneous sheet of cells and converts it into an ordered array of unit eyes or ommatidia. Since the discovery of the furrow in 1976, positive and negative acting morphogens have been thought to be solely responsible for propagating the movement of the furrow across a motionless field of cells. However, a recent study has challenged this model and instead proposed that mechanical driven cell flow also contributes to retinal pattern formation. We will discuss both models and their impact on patterning.
Neglected intrapulmonary arteriovenous anastomoses: A comparative study of pulmonary right-to-left shunts in patients with patent foramen ovale
Authors: Chen Anni , Zhu Jianbo , Zhu Lei , Tang Yunyi , Li Yun , Zhang Qi , Zhao Yeping , Ma Caiye , Liu Xiatian
Published: April 2023

Objective

Pulmonary right-to-left shunt (P-RLS) and patent foramen ovale right-to-left shunt (PFO-RLS) often appear in combination, and there are often differences and connections between them. Intrapulmonary arteriovenous anastomoses (IPAVAs), as part of P-RLS, are often overlooked because there are no technologies to detect and identify them. This study aimed to further clarify the incidence and characteristics of P-RLS with the help of contrast transesophageal echocardiography (c-TEE) and contrast transthoracic echocardiography (c-TTE), providing a reference for clinically relevant research and patent foramen ovale (PFO) management disposal decisions.

Methods

We retrospectively investigated 414 subjects who came to our hospital for c-TEE from October 2021 to July 2022, and all subjects completed c-TTE simultaneously. 7 Patients who were newly diagnosed with an atrial septal defect were excluded. Eventually, 407 patients were included in this study. Among them, 157 patients with PFO (58 patients were treated with PFO closure subsequently) and 250 patients without PFO confirmed by c-TEE were finally enrolled. In the process, we observed and analysed the presence of P-RLS.

Results

A total of 407 patients were included in the final analysis and divided into PFO group (N = 157) and non-PFO group (N = 250) according to the results of c-TEE. Whether at rest or after Valsalva maneuver, the incidence of P-RLS was significantly higher under c-TEE than under c-TTE in the two groups (P < 0.001). For both c-TTE and c-TEE, the incidence of P-RLS was slightly higher after Valsalva maneuver than at rest, but the difference was not significant (c-TTE: rest vs. Valsalva maneuver, P = 0.214; c-TEE: rest vs. Valsalva maneuver, P = 0.076). The Valsalva maneuver increased the incidence of P-RLS in the group without PFO, which was more significant in c-TEE (c-TTE: rest vs. Valsalva maneuver, P = 0.591; c-TEE: rest vs. Valsalva maneuver, P = 0.008). In both groups, the P-RLS semiquantitative grading was statistical significance under different states and examinations (P < 0.001).

Conclusion

The vast majority of P-RLS are grade 1–2 and are derived from physiological IPAVAs. Even so, attention should be given to the differentiation between P-RLS and PFO-RLS. c-TEE is an effective method to detect P-RLS; however, the recruitments of c-TEE and Valsalva maneuver to P-RLS should be noted.
The role of invasive and non-invasive imaging technologies and calcium modification therapies in the evaluation and management of coronary artery calcifications
Authors: Wopperer Samuel B. , Kotronias Rafail , Marin Federico , Benenati Stefano , Della Mora Francesco , Portolan Leonardo , Banning Adrian P. , De Maria Giovanni Luigi
Published: April 2023

The treatment of coronary artery disease (CAD) has advanced significantly in recent years due to improvements in medical therapy and percutaneous or surgical revascularization. However, a persistent obstacle in the percutaneous management of CAD is coronary artery calcification (CAC), which portends to higher rates of procedural challenges, post-intervention complications, and overall poor prognosis. With the advent of novel multimodality imaging technologies spanning from intravascular ultrasound to optical coherence tomography to coronary computed tomography angiography combined with advances in calcium debulking and modification techniques, CACs are now targets for intervention with growing success. This review will summarize the most recent developments in the diagnosis and characterization of CAC, offer a comparison of the aforementioned imaging technologies including which ones are most suitable for specific clinical presentations, and review the CAC modifying therapies currently available.
Human behavior in the time of COVID-19: Learning from big data
Authors: Lyu Hanjia , Imtiaz Arsal , Zhao Yufei , Luo Jiebo
Published: April 2023

Since the World Health Organization (WHO) characterized COVID-19 as a pandemic in March 2020, there have been over 600 million confirmed cases of COVID-19 and more than six million deaths as of October 2022. The relationship between the COVID-19 pandemic and human behavior is complicated. On one hand, human behavior is found to shape the spread of the disease. On the other hand, the pandemic has impacted and even changed human behavior in almost every aspect. To provide a holistic understanding of the complex interplay between human behavior and the COVID-19 pandemic, researchers have been employing big data techniques such as natural language processing, computer vision, audio signal processing, frequent pattern mining, and machine learning. In this study, we present an overview of the existing studies on using big data techniques to study human behavior in the time of the COVID-19 pandemic. In particular, we categorize these studies into three groups—using big data to measure, model, and leverage human behavior, respectively. The related tasks, data, and methods are summarized accordingly. To provide more insights into how to fight the COVID-19 pandemic and future global catastrophes, we further discuss challenges and potential opportunities.
Students’ development of deliberative competences: The contribution of democratic experiences in urban schools
Authors: Strijbos Jetske , Engels Nadine
Published: April 2023

Introduction

A democratic school culture has been identified in previous research as a lever for the development of deliberative competences. However, the antecedents of deliberative competence development at school level are less examined. Therefore, this study investigated the impact of student characteristics (age, gender, finality), urban school contexts (location of the school, socioeconomic and cultural characteristics of the student population) and different dimensions of the perceived democratic school culture (fair support, responsibility, co-decision, discussion, acceptance) on students’ mastery of three deliberative competences: tolerance, curiosity, and empathy.

Methods

A multilevel analysis of a survey, completed by 5,165 Dutch-speaking Belgian secondary school students was conducted.

Results

This study revealed the importance of the perceived fair support from teachers, opportunities to discuss, and acceptance by peers at school for the mastery of deliberative competences. Furthermore, urban schools were discovered to be strong negative predictors of all three competences, although fair support and discussion opportunities appear to partially compensate for this effect.

Discussion

These results highlight the importance of a democratic school culture, especially in urban schools, for developing empathy, tolerance, and curiosity. Moreover, the detailed results of this study could guide urban school teams in shaping democratic learning environments.
Chemical stability of carbon pool in peatlands dominated by different plant types in Jilin province (China) and its potential influencing factors
Authors: Cong Jinxin , Gao Chuanyu , Zhao Haiyang , Han Dongxue , Meng Fang , Wang Guoping
Published: April 2023

Introduction

The peat carbon pool stores 30% of the total global soil carbon accounting for 3–4% of the global land surface. The stability of the peatland carbon pool is a key factor affecting global carbon cycling that is seriously disturbed by climate change and regional human activities. However, the impact of these factors on carbon pool stability remains poorly understood.

Methods

Based on the physicochemical properties and carbon compounds of 973 peat samples from Jilin Province (China), which are widely distributed in different altitude regions of the Changbai Mountains, we investigated the stability of the carbon pool in different dominant plants and degradation types of peatlands and assessed the effects of regional environmental factors on the peatland carbon pool.

Results and Discussion

Our results showed that the carbohydrate content of peat soils in different peatland types ranged from 33.2 ± 6.9% to 40.5 ± 4.8%, and the aromatic content ranged from 19.8 ± 1.2% to 22.7 ± 2.3%. Bulk density is the most important physicochemical factor, and annual average temperature is the most important environmental factor that influences carbon stability. The effects of selected environmental factors on the peatland carbon pool covered by different plants were different, and the carbon stability in shrub peatlands is more sensitive to climate characteristics than in peatlands dominated by the other two plant types. Peatland degradation decreases the carbon stability in herb and herb/shrub peatlands and increases the carbon stability in shrub peatlands, leading the peatland carbon pool to be more easily influenced by regional human activities than natural peatlands.
The causal association between smoking initiation, alcohol and coffee consumption, and women’s reproductive health: A two-sample Mendelian randomization analysis
Authors: Jiang Zhaoying , He Renke , Wu Haiyan , Yu Jiaen , Zhu Kejing , Luo Qinyu , Liu Xueying , Pan Jiexue , Huang Hefeng
Published: April 2023

Objective: A number of epidemiological studies have demonstrated that smoking initiation and alcohol and coffee consumption were closely related to women’s reproductive health. However, there was still insufficient evidence supporting their direct causality effect.

Methods: We utilized two-sample Mendelian randomization (TSMR) analysis with summary datasets from genome-wide association study (GWAS) to investigate the causal relationship between smoking initiation, alcohol and coffee consumption, and women’s reproductive health-related traits. Exposure genetic instruments were used as variants significantly related to traits. The inverse-variance weighted (IVW) method was used as the main analysis approach, and we also performed MR-PRESSO, MR-Egger, weighted median, and weighted mode to supplement the sensitivity test. Then, the horizontal pleiotropy was detected by using MRE intercept and MR-PRESSO methods, and the heterogeneity was assessed using Cochran’s Q statistics.

Results: We found evidence that smoking women showed a significant inverse causal association with the sex hormone-binding globulin (SHBG) levels (corrected β = −0.033, p = 9.05E-06) and age at menopause (corrected β = −0.477, p = 6.60E-09) and a potential positive correlation with the total testosterone (TT) levels (corrected β = 0.033, p = 1.01E-02). In addition, there was suggestive evidence for the alcohol drinking effect on the elevated TT levels (corrected β = 0.117, p = 5.93E-03) and earlier age at menopause (corrected β = −0.502, p = 4.14E-02) among women, while coffee consumption might decrease the female SHBG levels (corrected β = −0.034, p = 1.33E-03).

Conclusion: Our findings suggested that smoking in women significantly decreased their SHBG concentration, promoted earlier menopause, and possibly reduced the TT levels. Alcohol drinking had a potential effect on female higher TT levels and earlier menopause, while coffee consumption might lead to lower female SHBG levels.
Integrative metabolomic and transcriptomic analysis reveals difference in glucose and lipid metabolism in the longissimus muscle of Luchuan and Duroc pigs
Authors: Deng Liyan , Li Wangchang , Liu Weiwei , Liu Yanwen , Xie Bingkun , Groenen Martien A. M. , Madsen Ole , Yang Xiaogan , Tang Zhonglin
Published: April 2023

Luchuan pig, an obese indigenous Chinese porcine breed, has a desirable meat quality and reproductive capacity. Duroc, a traditional western breed, shows a faster growth rate, high feed efficiency and high lean meat rate. Given the unique features these two porcine breeds have, it is of interest to investigate the underlying molecular mechanisms behind their distinctive nature. In this study, the metabolic and transcriptomic profiles of longissimus dorsi muscle from Duroc and Luchuan pigs were compared. A total of 609 metabolites were identified, 77 of which were significantly decreased in Luchuan compared to Duroc, and 71 of which were significantly elevated. Most differentially accumulated metabolites (DAMs) upregulated in Luchuan were glycerophospholipids, fatty acids, oxidized lipids, alcohols, and amines, while metabolites downregulated in Luchuan were mostly amino acids, organic acids and nucleic acids, bile acids and hormones. From our RNA-sequencing (RNA-seq) data we identified a total of 3638 differentially expressed genes (DEGs), 1802 upregulated and 1836 downregulated in Luchuan skeletal muscle compared to Duroc. Combined multivariate and pathway enrichment analyses of metabolome and transcriptome results revealed that many of the DEGs and DAMs are associated with critical energy metabolic pathways, especially those related to glucose and lipid metabolism. We examined the expression of important DEGs in two pathways, AMP-activated protein kinase (AMPK) signaling pathway and fructose and mannose metabolism, using Real-Time Quantitative Reverse Transcription PCR (qRT-PCR). Genes related to glucose uptake, glycolysis, glycogen synthesis, fatty acid synthesis (PFKFB1, PFKFB4, MPI, TPI1, GYS1, SLC2A4, FASN, IRS1, ULK1) are more activated in Luchuan, while genes related to fatty acid oxidation, cholesterol synthesis (CPT1A, HMGCR, FOXO3) are more suppressed. Energy utilization can be a decisive factor to the distinctive metabolic, physiological and nutritional characteristics in skeletal muscle of the two breeds we studied. Our research may facilitate future porcine breeding projects and can be used to reveal the potential molecular basis of differences in complex traits between various breeds.