bluuebunny/crossref_metadata_2025 huggingface dataset:
Cooperation with Commodity Groups and Hands-On Demonstrations Improve the Effectiveness of Commodity-Focused Educational Programs
Authors: Kandel Herman , Ransom Joel , Torgerson David , Wiersma Jochum
Published: August 2023

Wheat and soybean producers pay a small amount per bushel produced as a check-off. Funds are used for research, outreach, and crop promotion. Commodity organizations and Extension joined forces to develop multi-state educational outreach on spring wheat and soybean production. Participatory planning involved producers in developing these educational events. The financial resources and availability of contact information from the commodity groups combined with the knowledge base and teaching skills from Extension resulted in well attended, valuable educational events. "Speed" hands-on demonstrations were well received. Extension working together with commodity groups can be a model for other Extension programming efforts.
PENERAPAN KEBIJAKAN ASET TETAP DENGAN PSAP NO.07 PADA KANTOR DESA UJUNG BATU KEC. PELAIHARI KAB. TANAH LAUT
Authors: Rina Pebriana  , Maulida Hirdianti Bandi  , Hartati
Published: August 2023

Penelitian ini bertujuan untuk mengetahui penerapan Pernyataan  Standar Akuntasi Pemerintahan Nomor 07  tentang Aset Tetap berdasarkan Peraturan Pemerinta Republik Indonesia Nomor71 Tahun 2010 pada Kantor Desa Ujung Batu Kec. Pelaihari Kab. Tanah Laut telah dilaksanakan atau belumnya peraturan tersebut pada poin Pengakuan Aset Tetap, Penyusutan Aset Tetap dan Penyajian Aset Tetap. Metode analisis yangdigunakan pada penelitian ini yaitu deskriptip kualitatif. Data yang digunakan pada peneltian ini yaitu Buku Inventari Desa, Laporan Kekayaan Milik Desa dan Daftar Aset Tetap untuk tahun 2019,2020,2021 dan 2022. Teknik Pengumpulan data dari penelitian ini yaitu, studi pustakan, dokumentasi dan wawanara. Hasil Penelitian ini menunjukan belum dilaksanakan secara maksimal PSAP No.07 pada perhitungan penyusutan aset tetap dan pada penyajian aset tetap pada laporan kekayaan milik desa, tetapi pada poin pengakuan aset tetap telah sesuai dengan PSAP No.07 Tahun 2010.

Kata kunci: Penerapan, Aset Tetap, Penyusutan, Penyajian
Ultracompact Multimode Meta-Microscope Based on Both Spatial and Guided-Wave Illumination
Authors: Ye Xin , Sun Jiacheng , Jiang Wei , Yu Rongtao , Chen Chen , Xiao Xingjian , Qian Xiao , Huang Chunyu , Hu Yong , Zhu Shining , Li Tao
Published: August 2023

Microscopic imaging technology is an indispensable foundation in the biomedical field, which enables powerful capability in bio-investigations. Aiming for more convenience and adaptability, a multifunctional microscope with a miniaturized scheme is a new requirement, but remains a challenge. Here, we propose an ultracompact microscope based on both spatial and guided-wave illumination that can work in bright-field, dark-field, and fluorescence imaging modes separately and simultaneously by conveniently switching the light source. The proposed guided-wave illumination not only provides a noise-free imaging mode, but also further reduces the system size. Moreover, a metalens array is specifically designed by a hexagonal arrangement to enable multi-field imaging and enlarge the field of view. The experiment results demonstrate that the half-pitch resolution is about 714 nm with an imaging magnification of 3.5×, with a field of view of 0.543 mm
2
and a space-bandwidth product of 4.26 megapixels. As examples, the multimode microscope is applied to image different cells and flowing microspheres in microtubules, showing comparable image quality with the images taken through the traditional microscope under guided-wave illumination. This demonstrates the possibility of the meta-microscope to be combined with microfluidic technology and further realize miniaturized microfluidic imaging systems. Our ultracompact multimode microscope has shown powerful capabilities for a new scheme of bio-observation and investigations.
Unified Picture on Temperature Dependence of Lithium Dendrite Growth via Phase-Field Simulation
Authors: Li Yajie , Zhao Wei , Zhang Geng , Shi Siqi
Published: August 2023

Lithium dendrite growth due to uneven electrodeposition may penetrate the separator and solid electrolyte, causing inner short circuit and potential thermal runaway. Despite great electrochemical phase-field simulation efforts devoted to exploring the dendrite growth mechanism under the temperature field, no unified picture has emerged. For example, it remains open how to understand the promotion, inhibition, and dual effects of increased temperature on dendrite growth when using different electrolyte types. Here, by comprehensively considering the temperature-dependent Li
+
diffusion coefficient, electrochemical reaction coefficient, and initial temperature distribution in phase-field model, we propose that the activation–energy ratio, defined as the ratio of electrochemical reaction activation energy to electrolyte Li
+
diffusion activation energy, can be used to quantify the effect of temperature on dendrite morphology. Specifically, we establish a mechanism diagram correlating the activation–energy ratio, uniform initial temperature, and maximum dendrite height, which unifies the seemingly contradictory simulation results. Furthermore, results based on nonuniform initial temperature distribution indicate that a positive temperature gradient along the discharging current facilitates uniform Li
+
deposition and local hotspot should be avoided. These findings provide valuable insights into the temperature-dependent Li dendrite growth and contribute to the practical application of Li metal batteries.
Natural Evolutionary Gradient Descent Strategy for Variational Quantum Algorithms
Authors: Xie Jianshe , Xu Chen , Yin Chenhao , Dong Yumin , Zhang Zhirong
Published: August 2023

Recent research has demonstrated that parametric quantum circuits (PQCs) are affected by gradients that progressively vanish to zero as a function of the number of qubits. We show that using a combination of gradient-free natural evolutionary strategy and gradient descent can mitigate the possibility of optimizing barren plateaus in the landscape. We implemented 2 specific methods: natural evolutionary strategy stochastic gradient descent (NESSGD) and natural evolutionary strategy adapting the step size according to belief in observed gradients (NESAdaBelief) to optimize PQC parameter values. They were compared with standard stochastic gradient descent, adaptive moment estimation, and a version of adaptive moment estimation adapting the step size according to belief in observed gradients in 5 classification tasks. NESSGD and NESAdaBelief demonstrated some superiority in 4 of the tasks. NESAdaBelief showed higher accuracy than AdaBelief in all 5 tasks. In addition, we investigated the applicability of NESSGD under the parameter shift rule and demonstrated that NESSGD can adapt to this rule, which means that our proposed method could also optimize the parameters of PQCs on quantum computers.
Human Expansion-Induced Biodiversity Crisis over Asia from 2000 to 2020
Authors: Yang Chao , Li Qingquan , Wang Xuqing , Cui Aihong , Chen Junyi , Liu Huizeng , Ma Wei , Dong Xuanyan , Shi Tiezhu , Meng Fanyi , Yan Xiaohu , Ding Kai , Wu Guofeng
Published: August 2023

Asia stands out as a priority for urgent biodiversity conservation due to its large protected areas (PAs) and threatened species. Since the 21st century, both the highlands and lowlands of Asia have been experiencing the dramatic human expansion. However, the threat degree of human expansion to biodiversity is poorly understood. Here, the threat degree of human expansion to biodiversity over 2000 to 2020 in Asia at the continental (Asia), national (48 Asian countries), and hotspot (6,502 Asian terrestrial PAs established before 2000) scales is investigated by integrating multiple large-scale data. The results show that human expansion poses widespread threat to biodiversity in Asia, especially in Southeast Asia, with Malaysia, Cambodia, and Vietnam having the largest threat degrees (∼1.5 to 1.7 times of the Asian average level). Human expansion in highlands induces higher threats to biodiversity than that in lowlands in one-third Asian countries (most Southeast Asian countries). The regions with threats to biodiversity are present in ∼75% terrestrial PAs (including 4,866 PAs in 26 countries), and human expansion in PAs triggers higher threat degrees to biodiversity than that in non-PAs. Our findings provide novel insight for the Sustainable Development Goal 15 (SDG-15 Life on Land) and suggest that human expansion in Southeast Asian countries and PAs might hinder the realization of SDG-15. To reduce the threat degree, Asian developing countries should accelerate economic transformation, and the developed countries in the world should reduce the demands for commodity trade in Southeast Asian countries (i.e., trade leading to the loss of wildlife habitats) to alleviate human expansion, especially in PAs and highlands.
Prevalence and Features of Post-stroke Urinary Incontinence: A Retrospective Cohort Study
Authors: Sadeghi Mohammad Amin , Hemmati Sara , Emami Razavi Seyede Zahra , Vahabizad Fahimeh , Yekaninejad Mir Saeed , Azadvari Mohaddeseh
Published: August 2023

Background: Long-term complications of stroke, persisting for more than 6 months after the initial event, substantially reduce the quality of life (QoL) in a significant percentage of stroke survivors. In this paper, we studied the prevalence of long-term urinary incontinence (UI) in post-stroke patients. In addition, we attempted to identify patient characteristics which were associated with higher UI prevalence, higher UI severity, and less UI-associated QoL. Methods: Medical records in a tertiary referral hospital were used to contact patients who had experienced a stroke between 6 to 32 months before the study date. The patients were given the International Consultation on Incontinence Questionnaire Short Form (ICIQ-UI-SF) questionnaire for determining the presence of UI and its severity. UI-positive patients were then given the I-QOL questionnaire to determine their QoL. Results: The prevalence of UI in our study population (n=189) was 31%. Older age at the time of stroke was associated with higher UI severity (r=0.290) and lower QoL (r=-0.265). Furthermore, the presence of movement limitation was associated with higher UI prevalence (P<0.001, OR=3.89) and severity (P=0.002, d=1.05). Movement limitation also significantly impacted the psychological and social aspects of UI-associated QoL (P=0.035, d=-0.74). Conversely, higher body mass indices (BMIs) were associated with lower UI severity (r=-0.346) and higher QoL (r=0.281). Conclusion: In conclusion, UI continues to be prevalent in stroke survivors long after the cerebrovascular accident (CVA). As a result, these patients require continuous monitoring and UI prevention.
Cardio-Pulmonary Histopathology with Clinical Correlations of Deceased Patients with COVID-19: A Case Series in Tehran, Iran
Authors: Soleiman-Meigooni Saeed , Yaghmayee Ramin , Mohammadi Shadi , Ahmadi Mousa , Sakhabakhsh Mehdi , Hamidi-Farahani Ramin , Hazrati Ebrahim , Jazayeri Seyed Mohammad , Fotoohi Mahtab , Motemaveleh Akram , Doulatabadi-Farahani Vahid , Shahmohamadi Farhad , Kazemi-Galougahi Mohammad Hassan , Asgari Ali , Aminianfar Mohammad , Darvishi Mohammad , Mohajeri-Iravani Mojgan , Gholizadeh Omid
Published: August 2023

Background: SARS-CoV-2 may affect vital organs. The present study investigated the histopathology of pulmonary and cardiac tissues with clinical correlation in deceased patients with COVID-19. Methods: We obtained pulmonary and cardiac tissues from 30 deceased patients with COVID-19 in Tehran, Iran, from January to May 2021. Sampling was performed through a percutaneous needle biopsy. After slide preparation, two expert pathologists studied them. We assessed the correlation between clinical and pathological data by Fisher’s exact test. Results: The mean age of the patients was 73.8±13.4 years, and the male-to-female ratio was 23/7. The most common underlying disease was hypertension (HTN) in 25 patients (83%). Fifty-five tissue samples were achieved, including 28 pulmonary and 27 cardiac samples. Our results showed that all patients (100%) developed diffuse alveolar damage (DAD), and 26 (93%) developed hyaline membrane formation. The most common phase of DAD was the exudative-proliferative phase in 16 (57.1%). Three cardiac samples (11%) revealed myocarditis, and seven (26%) showed cardiomyocyte hypertrophy. In univariate analysis using Fischer’s exact test, myocarditis had significant relationships with C-reactive protein (CRP) levels higher than 80 mg/dL (P=0.008) and elevated cardiac troponin levels higher than two-fold (P=0.01). Conclusion: COVID-19 can affect the major vital organs. However, only myocarditis had a significant relationship with the circulating levels of inflammatory factors.
Influence of HLA-A, -B, -DR Polymorphisms on the Severity of COVID-19: A Case-Control Study in the Iranian Population
Authors: Mashayekhi Parisa , Omrani Mir Davood , Yassin Zeynab , Dehghanifard Ali , Ashouri Leila , Aghabozorg Afjeh Sara Sadat , Shabanzadeh Zahra
Published: August 2023

Background: As an emerging pandemic disease, COVID-19 encompasses a spectrum of clinical diagnoses, from the common cold to severe respiratory syndrome. Considering the shreds of evidence demonstrating the relationship between human leukocyte antigen (HLA) allele diversity and infectious disease susceptibility, this study was conducted to determine the association of HLA alleles with COVID-19 severity in Iranian subjects. Methods: In this case-control study, a total of 200 unrelated individuals (consisting of 100 people with severe COVID-19 and an average age of 55.54 as the case group, and 100 patients with mild COVID-19 with an average age of 48.97 as the control group) were recruited, and HLA typing (Locus A, B, and DR) was performed using the Olerup sequence-specific oligonucleotide (SSO) HLA-typing kit. Results: Our results showed that HLA-A*11 and HLA-DRB1*14 alleles were more frequently observed in severe COVID-19 cases, while HLA-B*52 was more common in mild cases, which was in agreement with some previous studies. Conclusion: Our results confirmed the evidence for the association of HLA alleles with COVID-19 outcomes. We found that HLA-A*11 and HLA-DRB1*14 alleles may be susceptibility factors for severe COVID-19, while HLA-B*52 may be a protective factor. These findings provide new insight into the pathogenesis of COVID-19 and help patient management.
Impact of analgesics on the risk of ovarian cancer; a systematic review and meta-analysis of cohort and case-control studies
Authors: Sadeghi Javad , Bazzazi Saba , Fattahi Farinaz , Mousavi Moloud Alsadat , Tajbakhsh Ardeshir , Rassouli Sadaf , Sangi Siavash , Ghezelbash Mahshad , Ghorbani Anna
Published: August 2023

Introduction: Ovarian cancer is the sixth leading cancer-related mortality cause in women worldwide. Analgesics may hinder the occurrence of ovarian cancer through inflammation relief. The present study seeks to examine the relationship between analgesic consumption and ovarian cancer risk through a systematic review and meta-analysis. Materials and Methods: PubMed, Scopus, Web of Science, Cochrane databases, and Google Scholar search engines were searched for works published by May 2023 using standard keywords to collect the required data sources. Acquired data were then analyzed in STATA version14, considering a significance level of P < 0.05 in statistical tests. Results: The present meta-analysis comprised 21 studies (14 case-control and 7 cohort studies) performed on 53,755 subjects. Results indicated that taking aspirin reduced the risk of ovarian cancer by 8% (OR: 0.92; 95% CI: 0.87, 0.98), whereas other non-aspirin NSAIDs (non-steroidal anti-inflammatory drugs) did not significantly affect the ovarian cancer risk (OR: 0.91; 95% CI: 0.81, 1.02). Similar results were observed in the case of ibuprofen and acetaminophen, with non-significant relationships between the risk of ovarian cancer and with the consumption of both acetaminophen (OR: 0.95; 95% CI: 0.84, 1.08) and ibuprofen (OR: 0.76; 95% CI: 0.50, 1.14). Furthermore, the duration of analgesic consumption was not significantly linked to the risk of ovarian cancer in the case of all studied drugs. Conclusion: Among aspirin, ibuprofen, acetaminophen, and non-aspirin NSAIDs, only aspirin was found to reduce the risk of ovarian cancer in women while the other studied drugs did not influence the studied risk. However, further research is recommended to confirm the results. Registration: This study has been compiled based on the PRISMA checklist, and its protocol was registered on the PROSPERO (CRD42023434730) and Research Registry (UIN: reviewregistry1668) websites.
Thymoma; clinical presentations, pathology, and prognostic factors – a surgery point of view
Authors: Hemmati Hamid Reza , Memarian Mohammad
Published: August 2023

Thymomas are rare tumors that can present with a wide range of clinical characteristics. The presence of symptoms and paraneoplastic syndromes, such as myasthenia gravis, along with the histological subtype and stage of the tumor, are important factors that guide the treatment approach and prognosis for patients with thymomas. The prognosis for thymoma varies depending on several factors, including the stage and type of the tumor, as well as the presence of associated autoimmune diseases. Generally, early-stage thymomas have a better prognosis compared to advanced-stage tumors. Regular follow-up with a multidisciplinary team, including oncologists and thoracic surgeons, is essential for long-term management and surveillance of patients.
Essential Oil Components and Antitrichomonal Effects of Piper nigrum L.
Authors: Jamshidi-Zad Ali , Dastan Dara , Fallah Mohammad , Azizi-Jalilian Farid , Matini Mohammad
Published: August 2023

Background: Trichomoniasis, caused by Trichomonas vaginalis protozoan, is the most common nonviral sexually transmitted infection (STI) worldwide. Although metronidazole and tinidazole are the only approved drugs for treatment, drug-resistant cases of infection are on the rise. The aim of this study was the evaluation of antitrichomonal potential of Piper nigrum and limonene. The phytochemical profile of P. nigrum oil was also investigated. Methods: The parasites were treated in vitro with essential oil and different extracts of P. nigrum seed and limonene using microtiter plate method. The oil of P. nigrum was also analyzed by gas chromatography-mass spectrometry and gas chromatography-flame ionization detector. Furthermore, the cytotoxicity assay of P. nigrum oil and limonene were screened on Vero cell line by MTT method. Results: The tested P. nigrum fractions were able to kill 100% of Trichomonas trophozoites at minimum lethal concentration (MLC) and reduce the trophozoite viability at sub-MLC and lower concentrations. After 48 hours exposure, the most potent fraction was the n-hexane extract with MLC of 78 µg/mL followed by the essential oil and methanol extract with MLC of 156 µg/mL, limonene (MLC=1250 µg/mL), and then, aqueous extract with MLC value of 25 mg/mL. Moreover, according to cytotoxicity assay, P. nigrum oil was less toxic to Vero cell than limonene, with a selectivity index (SI) of 13.2 and 2.04, respectively. Conclusion: This study clearly demonstrated the trichomonacidal potential of P. nigrum. Thus, P. nigrum fractions can be considered promising antiprotozoal agents and the basis for further development to discover new phytochemicals compounds.
The Role of Cydonia oblonga, Portulaca oleracea, and Artemisia dracunculus on Hypoxia
Authors: Hosseinzadeh Mohammad Hossein , Eghbali Mohammad , Hashemi Zahra , Naserirad Narges , Shirdel Mahbube , Rafizadeh Melika , Farzin Davood , Ebrahimzadeh Mohammad Ali
Published: August 2023

Background: Hypoxia exists in some malignancies and is a prognostic risk factor contributing to tumor growth and metastasis. Anti-hypoxic compounds may improve this situation and be considered as anti-cancer agents. In previous reports, Cydonia oblonga, Portulaca oleracea, and Artemisia dracunculus showed anti-cancer activities. So, we investigated the anti-hypoxic activities of C. oblonga, P. oleracea, and A. dracunculus to evaluate the possible mechanism of their effectiveness in treating cancer. Methods: Total phenolic and flavonoid contents and HPLC analysis were performed on C. oblonga leaves, P. oleracea, and A. dracunculus aerial parts extract. Anti-hypoxic activities were evaluated in asphyctic, haemic, and circulatory hypoxia models. Results: A. dracunculus extract (at 250 mg/kg) significantly improved the survival time compared to the normal saline (P<0.0001) in asphyctic hypoxia, even its effect was significantly better than phenytoin in this dose (P=0.0005). Although the extracts increased the survival time in other doses, their effects were not significant (P>0.05). In haemic hypoxia, the extracts were ineffective at any dose (P>0.05). At 250 mg/kg, P. oleracea and A. dracunculus significantly increased the survival time (P<0.001 and P<0.05, respectively) in circulatory hypoxia. Their effects were similar to propranolol (P>0.05). Conclusion: The anti-cancer effects of C. oblonga are not dependent on the anti-hypoxic effects. P. oleracea and A. dracunculus have anti-hypoxic effects only in high doses, indicating their extracts’ weak anti-hypoxic ability or the presence of potent anti-hypoxic compounds with low concentrations in them.
Eculizumab in kidney diseases
Authors: Pour-Reza-Gholi Fatemeh , Assadiasl Sara
Published: August 2023

The C5 inhibitor monoclonal antibody, eculizumab, has been approved for the treatment of atypical hemolytic uremic syndrome (aHUS) and paroxysmal nocturnal hemoglobinuria (PNH); however, the efficacy and safety of this drug in treating other complement-related renal diseases has not yet been elucidated. The high cost of eculizumab therapy and the rare adverse effects have created a paradox in conducting large clinical trials. Therefore, there is a need to increase clinicians’ awareness of the available data on the efficacy/safety of this drug in treating renal diseases. Herein, we have reviewed the outcomes of the administration of eculizumab in aHUS, PNH, lupus erythematosus nephritis, C3 glomerulonephritis, IgA nephropathy, and antibody-mediated rejection (AMR) in highly sensitized patients. Initial findings suggest its efficacy in treating acute injuries but lower effectiveness in preventing chronic lesions. Besides, early diagnosis and timely initiation of eculizumab are of particular importance.
A data set of monthly freshwater fluxes from the Greenland ice sheet’s marine-terminating glaciers on a glacier–basin scale 2010–2020
Authors: Karlsson Nanna B. , Mankoff Kenneth D , Solgaard Anne M , Larsen Signe H , How Penelope R , Fausto Robert S , Sørensen Louise S
Published: August 2023

The loss of mass from the Greenland ice sheet causes an increasing influx of freshwater to the Greenlandic fjords and the oceans. Freshwater fluxes from marine-terminating glaciers are important to understand fjord circulation and ecosystem dynamics. Here, we present a data set constructed by reformulating existing products into a shared temporal and spatial framework. We combine three publicly available data sets of solid-ice discharge (iceberg), liquid-surface runoff (runoff) and basal melt to present a cohesive overview of the flow of freshwater from marine-terminating glaciers to the Greenlandic fjords. We also calculate glacier drainage basins and compare our findings to previous studies showing that drainage-basin sizes may vary considerably depending on how they were reconstructed. The data set will be a valuable asset to oceanographic, glaciological and marine biological research activities.
The value and resilience of beach tourism during the COVID pandemic
Authors: Houston James
Published: August 2023

The coronavirus disease (COVID) had a greater impact on travel and tourism (T&T) than on any other industry sector, causing the worst downturn in world and U.S. history. The downturn in U.S. T&T caused a $937 billion drop in Gross Domestic Product (GDP) and a 7.1 million job loss in 2020 and a $708 billion GDP drop and 6.3 million job loss in 2021. Trillion dollar government programs saved the sector from complete collapse. Although overall T&T in the U.S. was hard hit in 2020 and did not recover greatly in 2021, beach tourism had a very different response to COVID. Some beaches were closed for months during the first half of 2020, but beach tourism largely recovered by the middle of 2020 as people decided the safest recreation during COVID was outdoors in the sun and fresh air of beaches or parks. Scientists have since come to the same conclusion. The number of international visitors remained low as air transportation remained largely dormant, but the number of domestic tourists going to beaches recovered in 2020 and boomed in 2021 despite the pandemic. Beach tourist spending in 2021 often greatly exceeded pre-pandemic 2019 levels and caused hotel and rental properties to hit capacity limits. The collapse of beach tourism in the first half of 2020, largely due to beach closures, highlighted its value to the economy. The recovery of beach tourism in the second half of 2020 and boom in 2021, despite continued problems in non-beach tourism, demonstrated its resilience. The boom continued in 2022 and 2023.
The During Nearshore Event Experiment (DUNEX): A collaborative coastal community experiment to address coastal resilience
Authors: Straub Jessamin , Cialone Mary , Raubenheimer Britt , Brown Jenna , Elko Nicole , Brodie Katherine
Published: August 2023

The During Nearshore Event Experiment (DUNEX) was a large-scale coastal field effort focused on improving understanding of during-storm nearshore processes to ultimately develop predictive technologies, engineering solutions, and actions to enhance coastal resilience. The experiments were conducted on the North Carolina coast by a multidisciplinary group of over 30 research scientists from 18 academic and federal institutions supporting over 30 graduate students and deploying over 300 instruments from 2019 to 2021. The overarching goal of DUNEX was to gather information collaboratively to improve understanding of the interactions of coastal water levels, waves, currents, beach and dune evolution, soil behavior, vegetation, and groundwater during major coastal storms that affect infrastructure, habitats, and communities. In the short term, these high-quality field measurements will lead to better understanding of during-storm processes and impacts and will enhance U.S. academic coastal research programs by providing opportunities for students to learn about field data collection and to potentially analyze data as part of their studies. Longer-term, DUNEX data and outcomes will improve the ability to predict extreme event physical processes and impacts, validate coastal processes numerical models, and improve coastal resilience strategies and communication methods for coastal communities impacted by storms. The purpose of this paper is to describe the motivation for and science goals of the experiment, how stakeholder needs led to these goals, collaborations amongst researchers, and the knowledge gained that will lead to tools to improve coastal resilience. Herein, we first describe how researchers worked with stakeholders to structure their community-driven needs into science-based requirements. Next, we summarize how federal, academic, and stakeholder researchers worked together to design and execute a multi-organizational experiment aligned with those requirements. Finally, we articulate early findings and lessons learned from the experiment. This paper does not summarize all the research findings from DUNEX, as analyses are still ongoing. An American Geophysical Union (AGU) Special Collection on Coastal Storm Research will be published in 2025 including outcomes from DUNEX research.
Prediksi Spot Price Komoditas Emas Berjangka dengan Pendekatan Vector Error Correction Model
Authors: Fahria Izma , Dalimunthe Desy Yuliana , Amelia Ririn , Sulistiana Ineu , Prayanti Baiq Desy Aniska
Published: August 2023

Time series data usually exhibit non-stationary behavior and involve interrelated variables. Thus, we need a model that can obtain good forecasting results from non-stationary time series data with multivariate variables. The Vector Error Correction Model (VECM) is a multivariate time series model which is a vector form of Vector Autoregressive Regression (VAR) for time series data that are non-stationary and have a cointegration relationship. This research was conducted to model the cointegration relationship in providing clarity on the long-term relationship of the influence of future prices and the Covid-19 pandemic on price movements of gold futures commodities and to predict spot price prediction modeling for gold futures commodities. The results of the research using the VECM (2) model, which is the best model, show that the future price of the gold commodity is quite dominant in influencing the value of the spot price of gold. The Covid-19 variable does not have a significant effect on the spot gold price variable.
On the Solution of Volterra Integro-differential Equations using a Modified Adomian Decomposition Method
Authors: Kareem Kabiru Oyeleye , Olayiwola Morufu , Asimiyu Oladapo , Akeem Yunus , Adedokun Kamilu , Alaje Ismail
Published: August 2023

The Adomian decomposition method’s effectiveness has been demonstrated in recent research, the process requires several iterations and can be time-consuming. By breaking down the source term function into series, the current work introduced a new decomposition approach to the Adomian decomposition method. As compared to the conventional Adomian decomposition approach, the newly devised method hastens the convergence of the solution. Numerical experiments were provided to show the superiority qualities.
Yaşlı Bireylerin Dijital Alanda Sosyalleşmesi Üzerine Bir Çalışma
Authors: TUNA UYSAL Meyrem , ZENGİN Şermin
Published: August 2023

Yaşlı bireyler yaşa bağlı farklılıklarla birlikte dijital teknoloji ürünlerini kullanmada zorluk yaşasalar bile gündelik yaşam pratikleriyle uyumlu olduğunda bu teknoloji ürünlerini öğrenme ve kullanma istekleri artmaktadır. Yaşlı bireylerin sosyalleşmesinde dijital teknolojinin rolünü tespit etmeyi amaçlayan bu çalışmada onların dijital teknolojiyle ilişkisinden hareketle bu teknoloji araçlarını kullanma sıklığı, kullanma amaçları ve sosyalleşmede dijital teknoloji ürünlerinin rolü ele alınmaktadır. Araştırma nitel araştırma yöntemi kullanılarak amaçlı örneklem yoluyla seçilmiş, Burdur ilinde yaşayan ve dijital teknoloji ürünlerini kullanan 65 yaş ve üzeri on üç katılımcıyla yarı yapılandırılmış görüşme formu kullanılarak derinlemesine yüz yüze görüşmeler gerçekleştirilmiştir. Araştırma sonucunda yaşlı bireylerin ihtiyaçları doğrultusunda günlük rutinleriyle uyumlu olduğunda dijital teknoloji ürünlerini kullanma istekleri artmakta, bu ürünlere daha kolay uyum sağlamakta ve dijital alanda sosyalleşmektedirler.
Informed consent of palliative patients to participate in quality of life research
Authors: Nesterenko V.G.
Published: August 2023

Informed consent as a procedure is mandatory in cases of patient participation in clinical trials of pharmaceuticals, preparation for surgical interventions, diagnostic and therapeutic invasive procedures, and even in surveys (questionnaires) on health issues according to the legislation of most countries of the world. The practice of obtaining informed consent in Ukraine is widespread and well-studied in cases of preparing palliative patients for operations, hospitalizations, invasive procedures, but there is a certain lack of information on obtaining informed consent when studying quality of life. In our research, we used the method of systematic analysis and the bibliosemantic method, with references to scientific and legal sources. As a result of the study, it was determined that informed consent is an important part of the legal regulation of medical care and social security in Ukraine and the world. We researched the issue of legal capacity, identified separate issues of confidentiality, compliance with the requirements of Ukrainian legislation regarding the observance of individual rights of patients that could potentially be violated during the study of the quality of life, collecting and processing answers to questionnaire, signing informed consent. The text of the informed consent can be modified for the purposes of the scientific study, but without violating the procedure of informing the patient (or his legal representative) about the goals and possible inconveniences of the study. The text of the informed consent must be signed by the patient (in his own hand) and the attending physician. If the patient cannot write independently, but understands the essence of the text of the informed consent and the questions of the questionnaire and gives clear and unambiguous answers to them, the questionnaire and the informed consent can be signed only by the attending physician.

Keywords: medical deontology, medical ethics, medical law, palliative and hospice care.
Calculating Weibull Coefficients Using the Maximum Likelihood Method and Comparing Performance Across Sites
Authors: KAPLAN Alper
Published: August 2023

In this study, the compliance of the Weibull Distribution Function (WDF) and actual wind data (WD) from three different locations were investigated. The coefficients of the WDF were calculated using the Maximum Likelihood Method (MLM) in the Adana, Osmaniye, and Hatay regions. The main purpose of this study is to observe the performances of the MLM in determining the coefficients of the WDF in different regions in different years and to examine the success of this method in estimating the mean wind power and speed of the determined regions. The performance of the indicated approach in all three selected locations was evaluated using the Root Mean Square Error (RMSE), Coefficient of Determination (R2), and Mean Percentage Error (MPE). Also wind power densities were estimated for all three regions, which are one of the most essential metrics for estimating a region's wind energy (WE) potential. WDF power densities were estimated and compared to real wind power densities generated from measured WD for three different places. The performance of the method described in this paper was investigated in depth in various places with varying geographic characteristics. In addition, in the same years, the performance of the chosen method was evaluated in detail in three distinct places, and it was seen how geographical factors affected the method's performance.
A Comparative Study on the Generalized Spherical Fuzzy Einstein Aggregation Operators
Authors: GÜNER Elif , AYGÜN Halis
Published: August 2023

Generalized spherical fuzzy set theory is a powerful and useful tool that is capable to process uncertainty and vagueness. In this study, we investigate some induced aggregation operators under the generalized spherical fuzzy environment with the help of Einstein norms operations to merge the generalized spherical fuzzy information into a single one in the decision-making process. After we observe some properties of the presented aggregation operators, we establish an algorithm to use in the solution of the multiple criteria group decision-making problems by using these aggregation operators and also we give an illustrative example. Then, we compare the results under all defined generalized spherical fuzzy Einstein aggregation operators used within the decision-making process.
Model and Modeling as a Network of Ideas -Graph analysis as an optional tool for understanding student’s models
Authors: zarfati Sheli Ben moshe
Published: August 2023

Building models is a well-known scientific tool and thinkingfacilitator, and as such, it carries high complexity anduncertainty. Complex phenomena, physical or abstract, can’tbe understood or learned from a mechanical view alone. Forthat, a more holistic and systemically approach is needed.Network theory relates to a phenomenon as a system of linksand nodes. In this paper, we show how computer modelsmade by students, can be analyzed as a network of ideas.Remapping the models, abstracting them into their distinguishedcomponents and links while assessing them with networkproperties, has been utilized as a comparative method,leading to new insights on the learning process and cognitivemechanism of building a model.
O USO PROLONGADO DOS BENZODIAZEPÍNICOS NO TRANSTORNO DE ANSIEDADE: UMA REVISÃO INTEGRATIVA DA LITERATURA
Authors: Begna Lima de Melo Wigna , Guilherme Galvão José , Robson de Araújo Lazaro , de Oliveira Nóbrega Rafaela
Published: August 2023

Introdução: Os benzodiazepínicos são substâncias que apresentam ação ansiolítica, sedativa, hipnótica, anticonvulsivante, considerados de grande utilidade em tratamentos de ansiedade; entretanto, seu uso prolongado pode ocasionar perda de desenvolvimento cognitivo, tolerância, abstinência, dependência química e até psicológica. Objetivos: Evidenciar o uso prolongado dos benzodiazepínicos no transtorno de ansiedade. Metodologia: O presente estudo trata-se de uma revisão integrativa, baseado em um levantamento de referências onde foram utilizadas as seguintes bases de dados: a Biblioteca Virtual em Saúde (BVS), através da base de dados Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS); Scientific Eletronic Library Online (SCIELO) e o PubMed, utilizando-se os seguintes descritores em saúde: “Transtorno de ansiedade’’; ‘’Benzodiazepínicos’’; ‘’ansiolíticos’’ e ‘’uso crônico’’. Os critérios de inclusão resumiram-se em publicações dos últimos 10 anos, artigos completos nos idiomas português e inglês. Foram excluídos os artigos que não correspondiam com a temática, duplicados, relatos de caso e capítulo de livros. Resultados e Discussões: Os benzodiazepínicos estão entre as drogas mais prescritas no mundo, sendo sua prescrição, muitas vezes, desnecessária, no qual se destaca a necessidade de avaliar cuidadosamente os riscos de uso indevido ao se prescrever benzodiazepínicos. O uso prolongado dos BZDs, normalmente, é visto como uma forma de fuga ao sofrimento psicológico, motivado pelo estresse que os indivíduos enfrentam diariamente, e a falta de conhecimento da população aos riscos que essa classe acarreta, quando utilizados de forma errônea. Conclusão: O uso indiscriminado dos benzodiazepínicos é frequente na população idosa, e isso pode causar risco de fraturas, dependência, tolerância e síndrome da abstinência, o que impacta significativamente no desenvolvimento de suas atividades cotidianas.

Descritores: Transtorno de ansiedade; benzodiazepínicos; ansiolíticos e uso crônico.
Analisis Pengetahuan, Kepatuhan, dan Outcome Klinis Pasien Hipertensi di Puskesmas Jetis Yogyakarta
Authors: Husna Nadia , Sugiyono Sugiyono , Yunilistianingsih Yunilistianingsih
Published: August 2023

Hipertensi telah menjadi masalah epidemi global yang mengalami peningkatan tiap tahunnya dan menjadi salah satu penyakit mematikan dengan komplikasi serius pada kadiovaskular. Pengetahuan dan kepatuhan adalah kunci optimalnya hasil klinis yang akan dirasakan oleh pasien. Tingkat pengetahuan merupakan salah satu faktor yang menentukan tingkat kepatuhan seorang pasien terhadap pengobatannya serta kepatuhan pengobatan seorang pasien akan menentukan hasil klinis yang akan dicapainya. Hasil klinis yang optimal akan dapat dicapai apabila kepatuhan pasien akan terapi yang dijalani bernilai baik. Metode yang digunakan adalah analitik observasional dengan pendekatan model cross sectional. Teknik pengambilan sampel menggunakan metode consecutive sampling. Subyek penelitian adalah pasien hipertensi dewasa di Puskesmas Jetis Kota dengan waktu penelitian di Bulan Agustus hingga Oktober 2020. Analisis univariat dilakukan pada deksripsi pasien dan pengobatan. Uji Kendal Tau dilakukan untuk menganalisis hubungan pengetahuan, kepatuhan, dan outcome klinis. Sebanyak 81 pasien hipertensi memenuhi kriteria masuk dalam penelitian ini. Prevalensi tertinggi penderita hipertensi adalah perempuan, usia 45-59 tahun, latar belakang pendidikan SMA, dan tidak bekerja. Pengobatan tunggal dengan amlodipin adalah terapi farmakologi yang banyak diberikan. Tidak ada hubungan antara pengetahuan dan kepatuhan serta tidak terdapat hubungan antara kepatuhan dan outcome klinis yang berupa ketercapaian sistol dan diastol.
Optimasi CMC-Na dan Gliserin dalam Sediaan Gel Ekstrak Lidah Buaya secara Simplex Lattice Design
Authors: Anita Martina Indah , Lestari Agatha Budi Susiana
Published: August 2023

Lidah buaya (Aloe barbandesis Mill.) merupakan tanaman yang mempunyai banyak manfaat salah satunya sebagai antibakteri. Ekstrak lidah buaya terbukti memiliki aktivitas sebagai antibakteri. Ekstrak lidah buaya dicoba untuk diformulasikan dalam bentuk sediaan gel karena kelebihan dari sediaan gel seperti mudah diaplikasikan pada kulit, tidak lengket dan mudah dicuci dengan air sehingga mempermudah dalam penggunaannya. Penelitian ini merupakan penelitian eksperimental murni yang bertujuan untuk mendapatkan komposisi CMC-Na sebagai gelling agent dan gliserin sebagai humektan yang optimal sehingga menghasilkan sifat fisik dan stabilitas fisik sediaan gel yang baik menggunakan metode optimasi Simplex Lattice Design. Hasil respon daya sebar, viskositas, pergeseran viskositas, dan pergeseran daya sebar digunakan untuk menentukan formula optimum. Data hasil uji dianalisis dengan ANOVA satu arah menggunakan Software Design Expert. Berdasarkan hasil penelitian, ditemukan formula optimum yaitu pada formula 1, 2, dan 3 dengan konsentrasi CMC-Na dan gliserin secara berturut-turut yaitu 1,500 g dan 1,750 g; 1,563 g dan 1,688 g; dan 1,625. Selain itu, formula 1, 2, dan 3 memenuhi parameter sifat fisik dan stabilitas fisik gel.
Efek Ramuan Tradisional Kaliputih terhadap Kadar Glukosa Darah Puasa, SOD, HbA1c, dan Histopatologi Pankreas pada Tikus Diabetes yang Diinduksi Streptozotocin
Authors: Kusumo Djati Wulan , Efendi Yuli Nurullaili , Kintoko Kintoko , Yuliana Tri Puspita , Waznah Urmatul , Muldiyana Tya , Pulhehe Hasni
Published: August 2023

Pencegahan diabetes mellitus (DM) dengan mengontrol kadar gula dan lipid adalah terapi utama. Ramuantradisional dari Kaliputih Batur, Banjarnegara, Jawa Tengah terdiri dari 11 macam tanaman obat terbukti secara empiris berkhasiat untuk penyakit diabetes melitus. Tujuan penelitian untuk menentukan efek ramuan tradisional Kaliputih pada kadar gula darah, SOD, HbA1c, dan gambaran histopatologi pankreas pada tikus. Ramuan disiapkan dengan metode infundasi. Tikus jantan albino Sprague Dawley (SD) dibagi menjadi 3 kelompok kontrol (normal, positif dan negatif) dan 3 kelompok uji dengan 3 dosis berbeda (18, 36, dan 54 mL/kg BB) yang sebelumnya diinduksi streptozotocin. Pengamatan dilakukan terhadap kadar glukosa darah puasa (GDP), superoksida dismutase (SOD), HbA1c, dan organ pankreas secara histopatologi dengan pewarnaan HE. Hasil pemeriksaan parameter biokimia kadar GDP menunjukkan adanya penurunan yang bermakna (P<0,05) pada dosis 36 dan 54 mL/kg BB. Aktivitas SOD terdapat perbedaan yang bermakna (P<0,05) pada semua dosis ramuan, dan kadar HbA1c menunjukan perbedaan bermakna (P<0,05) pada dosis 18 mL/kg BB dibandingkan kontrol negatif. Hasil pewarnaan HE menunjukkan tidak ada perubahan patologi yang spesifik pada organ pankreas dosis uji dibandingkan dengan kontrol negatif yang mengalami nekrosis di insula Langerhans. Ramuan tradisional untuk diabetes dari Kaliputih Batur, Banjarnegara, Jawa Tengah mampu menurunkan kadar gula darah tikus diabetes.
Analisis Senyawa Bioaktif Averrhoa bilimbi L. sebagai Penghambat Enzim Siklooksigenasi-2 secara In Siliko
Authors: Mulatsari Esti , Sumiyati Yati , Warni Warni
Published: August 2023

Belimbing wuluh (Averrhoa bilimbi L.) pada umumnya digunakan sebagai penambah cita rasa makanan dan obat tradisional untuk mengobati peradangan, sariawan, batuk, demam, encok, perdarahan pada rektum dan wasir. Penelitian secara in vivo dan in vitro terhadap belimbing wuluh menunjukkan adanya aktivitas antiinflamasi, namun belum dilaporkan senyawa aktif yang berperan dalam aktivitas antiinflamasi tersebut. Penelitian ini bertujuan untuk menganalisis enam puluh empat (64) senyawa bioaktif dari belimbing wuluh (Averrhoa bilimbi L.) sebagai inhibitor enzim cyclooxygenase-2 secara in silico dan memprediksi profil farmakokinetika dan toksisitas masing-masing senyawa. Enzim cyclooxygenase-2 merupakan enzim berperan dalam proses inflamasi dengan mengubah asam arakidonat menjadi prostaglandin. Prostaglandin yang meningkat akan menyebabkan inflamasi. Metode penelitian yang digunakan ialah molecular docking dengan aplikasi YASARA, PLANTS, Marvinsketch, Pymol, visualisasi dengan PLIP dan prediksi ADMET dengan pkCSM. Senyawa pembanding yang digunakan celecoxib. Hasil penelitian menunjukan ada 13 senyawa uji yang diprediksi memiliki aktivitas sebagai inhibitor COX-2 yang lebih baik dibandingkan celecoxib dengan sifat farmakokinetika yang baik. Asam erukat memiliki profil farmakokinetika dan toksisitas yang baik. Asam erukat berpotensi untuk dikembangkan sebagai obat inhibitor enzim cyclooxygenase-2.
Application of Solid Lipid Nanoparticles Method in Black Sea Cucumber (Holothuria atra) Extract Peel-off Gel Mask and Antioxidant Activity Tests
Authors: Rahmat Deni , Nafisa Safira , Odilia Catharina Maria
Published: August 2023

Black Sea cucumbers (Holothuria atra) are a potential source of active metabolites such as flavonoids widely used for nutraceutical, pharmaceutical, and cosmeceutical products. The type of nanoparticle that is often used in cosmetics and skin products is Solid Lipid Nanoparticles (SLN). In this study, the SLN of black sea cucumber extract will be prepared in the form of a peel-off gel mask as an antioxidant. Black sea cucumbers were extracted using the maceration method, while SLN preparation used high-shear homogenization and freeze-drying methods. Crude extract and SLN were formulated into peel-off gels and then evaluated, including organoleptic, homogeneity, viscosity, pH, spreadability, drying time, tensile strength test, and antioxidant activity using the DPPH method. The IC50 values of blank (F1), peel-off gel extract (F2), and nanoparticle peel-off gel extract (F3) were each 600.8727 ± 0.43; 580.7849±0.7; and 592.76±0.55 µg/mL. In conclusion, the SLN method can be applied to the formulation of black sea cucumber extract nanoparticles. However, peel-off gel masks from the crude and nanoparticle extracts have very weak antioxidant activity.
Estimation of electronic stopping cross sections of 4H-SiC for 2–26 MeV Al random-ion implantations
Authors: Mochizuki Kazuhiro , Nishimura Tomoaki , Mishima Tomoyoshi
Published: August 2023

Electronic stopping cross sections of 4H-SiC for 2−26 MeV Al random-ion implantations (S
e
random) were estimated from the reported dependence of the projected range on the ion-implantation energy (E
0). The estimated S
e
random was a couple of times larger than the reported electronic stopping cross section along the 〈0001〉 channel and proportional to the square root of the ion energy (E) in the case E < 10 MeV. When E ranged from 10 to 26 MeV, the S
e
random saturated around 5 × 10−13 eV cm2 atom−1, suggesting that the Bethe-Bloch region, where S
e
random decreases with E, should exist at E larger than 26 MeV.