bluuebunny/crossref_metadata_2025 huggingface dataset:
Foliar application of enriched banana pseudostem sap influences the nutrient uptake, yield, and quality of sweet corn grown in an acidic soil
Authors: Islam Mahammad Shariful , Kasim Susilawati , Amin Adibah Mohd , Alam Md. Khairul , Khatun Mst. Fatima , Ahmed Sharif , Gaber Ahmed , Hossain Akbar
Published: August 2023

Foliar fertilization is a reliable technique for correcting a nutrient deficiency in plants caused by inadequate nutrient supply to the roots in acid soil. Soluble nutrients in banana pseudostem sap might be effective to supplement chemical fertilizers. However, the limited nutrients in sole banana pseudostem sap as foliar fertilization may not meet-up the nutritional demand of the crop. Field trials were, therefore, conducted with the combination of soil-applied fertilizers with foliar spray of banana pseudostem sap to increase nutrient uptake, yield, and quality of sweet corn planted in acidic soil. Three treatments viz., 100% recommended dose of fertilizers (RD) as control (T1), 75% of RD applied in soil with foliar application of non-enriched banana pseudostem sap (T2), and 50% RD applied in soil with foliar spray of enriched banana pseudostem sap (T3) were replicated four times. The combination of soil-applied fertilizer with foliar spray of enriched banana pseudostem sap (T3) showed a significant increase in leaf area index (11.3%), photosynthesis (12%), fresh cob yield (39%), and biomass of corn (29%) over control. Besides, the 50% RD of soil fertilization with foliar spray of enriched pseudostem sap increased nutrient uptake in addition to an increase in sugar content, phenolic content, soluble protein, and amino acids of corn. Considering the economic analysis, the highest net income, BCR (3.74) and MBCR (1.25) values confirmed the economic viability of T3 treatment over the T1. The results suggest that foliar spray of enriched banana pseudostem sap can be used as a supplementary source of nutrients to enhance nutrient uptake by corn while increasing yield and minimizing chemical fertilizer use in acid soil.
“We’re tolerant and they’re prejudiced”: Same-sex marriage supporters’ and opponents’ perceptions of supportive and oppositional claims
Authors: Platow Michael J. , Knight Clinton G. , Van Rooy Dirk , Augoustinos Martha , Bar-Tal Daniel , Spears Russell
Published: August 2023

The current research examined the proposition that debates over same-sex marriage are characterized, at least in part, by conflicting understandings about what is and is not prejudiced, normative and true. Toward this end, Australians’ (N = 415) prejudice judgements of supportive and oppositional statements toward same-sex marriage were measured and analysed with analyses of variance. Unsurprisingly, same-sex marriage supporters perceived a supportive statement as unprejudiced, tolerant, truthful, in pursuit of individual liberty, and normative; oppositional statements were seen in precisely the opposite manner. Same-sex marriage opponents, however, disagreed, instead judging an oppositional statement as unprejudiced, tolerant, truthful, in pursuit of individual liberty, and normative; it was a supportive statement that was seen as relatively prejudiced. These effects remained even after controlling for independent expressions of in-group favouritism. The current data align with a collective naïve realism perspective, in which group members see their own views as veridical and those of disagreeing others as biased. We argue that prejudice-reduction efforts must be instantiated to facilitate a common in-group identity between supporters and opponents to enable consensus over facts and, ultimately, what is and is not prejudice. Without this consensus, each side of the political debate may simply hurl the pejorative label of “prejudice” against the other, with likely little opportunity for social influence and social change.
Association of trabecular bone score and bone mineral apparent density with the severity of bone fragility in children and adolescents with osteogenesis imperfecta: A cross-sectional study
Authors: Ohata Yasuhisa , Kitaoka Taichi , Ishimi Takeshi , Yamada Chieko , Nakano Yukako , Yamamoto Kenichi , Takeyari Shinji , Nakayama Hirofumi , Fujiwara Makoto , Kubota Takuo , Ozono Keiichi
Published: August 2023

Osteogenesis imperfecta (OI) is a hereditary skeletal disease characterized by bone fragility. Areal bone mineral density (BMD), evaluated by dual-energy X-ray absorptiometry (DXA), is used to assess bone brittleness. The height-adjusted BMD Z-score (BMDHAZ) is calculated in children and adolescents with OI to reduce the confounding factor of short stature. However, even with the BMDHAZ, severity evaluation in children and adolescents with OI is challenging because certain abnormalities in bone quality cannot be accurately assessed by BMD analysis. The trabecular bone scores (TBS) and bone mineral apparent density (BMAD), which represent the structural integrity of bone and bone-size-associated BMD, respectively, are associated with fracture risk. Recently, age- and sex-specific reference ranges have been reported, enabling the calculation of Z-scores for children. To evaluate which density measurements show the highest correlation with fracture risk, we analyzed the associations between the Z-scores of TBS, BMAD, and BMDHAZ, fracture rate, and genetic variants. We retrospectively reviewed 42 participants with OI aged 5 to 20 years who underwent DXA.COL1A1/2pathogenic variants were detected in 41 of the 42 participants. In participants with nonsense and frameshift variants (n = 17) resulting in haploinsufficiency and mild phenotype, the TBS Z-score was negatively correlated with fracture rate (FR) (r = -0.50,p= 0.042). In participants with glycine substitution (n = 9) causing the severe phenotype, the BMAD Z-scores were negatively correlated with FR (r = -0.74,p= 0.022). No correlation between the BMDHAZand FR was observed in both groups. These findings suggest that the TBS and BMAD are useful in assessing children and adolescents with OI with specific genetic variants.
Immunological Role of Megakaryocytes and Platelets during Influenza A Virus Infection
Authors: Rahman Fryad M.
Published: August 2023

Influenza viruses pose a serious threat to public health, with severe cases often characterized by lung damage and inflammation. However, the underlying mechanisms of these processes remain poorly understood. This study aimed to investigate the essential role of megakaryocytes (MKs) and platelets (PLTs) in influenza A virus (IAV) infections. Conducted at the Department of Rare Respiratory Diseases, Cystic Fibrosis, and Pulmonology, Nord University Hospital, Marseille, France, the study collected seventy blood samples between October 2018 and March 2019. Samples were obtained from healthy individuals and patients diagnosed with IAV. Messenger RNA was extracted from isolated PLTs and subjected to quantitative real-time-polymerase chain reaction using sets of primers targeting immune marker genes. Western blot analysis was also performed for confirmation, focusing on Fas Ligand (FasL). Results showed that PLTs from IAV-infected individuals expressed the FasL, tumor necrosis factor-related apoptosis-inducing ligand, and Granulysin (GNLY) receptors when activated. Furthermore, an in vitro assay revealed the presence of FasL receptors on infected CMK cell lines. In vivo investigations demonstrated that activated MKs and PLTs in mice also expressed FasL. Interestingly, none of the immune receptors under investigation were found in both MKs and PLTs in mouse model studies. In conclusion, MKs and PLTs play a significant role in influencing immune responses that may help prevent viral spread during infection. However, further examination of their mechanisms of action is warranted. Understanding the involvement of these cells in influenza pathogenesis could offer valuable insights for developing potential therapeutic strategies.
Performance evaluation of the novel 3D-printed aquatic plant-microbial fuel cell assembly with Eichhornia crassipes
Authors: Malinis Mel Patrick D. , Velasco Herna Jones F , Pamintuan Kristopher Ray
Published: August 2023

Plant-Microbial Fuel Cells (PMFCs) are a sustainable derivative of fuel cells that capitalizes on plant rhizodeposition to generate bioelectricity. In this study, the performance of the novel 3D-printed aquatic PMFC assembly with Eichhornia crassipes as the model plant was investigated. The design made use of 1.75 mm Protopasta Conductive Polylactic Acid (PLA) for the electrodes and 1.75 mm CCTREE Polyethylene Terephthalate Glycol (PETG) filaments for the separator. Three systems were prepared with three replicates each: PMFCs with the original design dimensions (System A), PMFCs with cathode-limited surface area variations (System B), and PMFCs with anode-limited surface area variations (System C). The maximum power density obtained by design was 82.54 µW/m2, while the average for each system is 26.99 µW/m2, 36.24 µW/m2, and 6.81 µW/m2, respectively. The effect of variations on electrode surface area ratio was also examined, and the results suggest that the design benefits from increasing the cathode surface area up to a cathode-anode surface area ratio of 2:1. This suggests that the cathode is the crucial component for this design due to it facilitating the rate-limiting step. Plant health was also found to be a contributing factor to PMFC performance, thereby suggesting that PMFCs are an interplay of several factors not limited to electrode surface area alone. The performance of the novel PMFC did not achieve those obtained from existing studies. Nevertheless, the result of this study indicates that 3D-printing technology is a possible retrofit for PMFC technology and can be utilized for scale-up and power amplification.
Crossing Crawford's conceptual divide: monumental linear earthworks in later prehistoric and early medieval Britain
Authors: Moore Tom , Reynolds Andrew , Garland Nicky , Harris Barney
Published: August 2023

In its early decades, Antiquity regularly featured the subject of linear earthworks that criss-cross the British landscape. Subsequently, however, discussion has been largely relegated to period-specific and local journals. As a result, interpretations of these imposing but often poorly dated earthworks have been drawn in the contrasting research traditions of later prehistory and the early medieval period. Here, the authors propose a comparative dialogue as a means for reinterpreting these landscape features, and as a lens through which to explore social complexity. Combined with advances in archaeometrical dating, this new approach promises to reinvigorate the study of some of Britain's largest archaeological monuments.
Global histone H2B degradation regulates insulin/IGF signaling‐mediated nutrient stress
Authors: Zhu Zhiwen , Li Dongdong , Jia Zeran , Zhang Wenhao , Chen Yuling , Zhao Ruixue , Zhang Yan‐Ping , Zhang Wen‐Hong , Deng Haiteng , Li Yinqing , Li Wei , Guang Shouhong , Ou Guangshuo
Published: August 2023

Eukaryotic organisms adapt to environmental fluctuations by altering their epigenomic landscapes and transcriptional programs. Nucleosomal histones carry vital epigenetic information and regulate gene expression, yet the mechanisms underlying chromatin‐bound histone exchange remain elusive. Here, we found that histone H2Bs are globally degraded in Caenorhabditis elegans during starvation. Our genetic screens identified mutations in ubiquitin and ubiquitin‐related enzymes that block H2B degradation in starved animals, identifying lysine 31 as the crucial residue for chromatin‐bound H2B ubiquitination and elimination. Retention of aberrant nucleosomal H2B increased the association of the FOXO transcription factor DAF‐16 with chromatin, generating an ectopic gene expression profile detrimental to animal viability when insulin/IGF signaling was reduced in well‐fed animals. Furthermore, we show that the ubiquitin‐proteasome system regulates chromosomal histone turnover in human cells. During larval development, C. elegans epidermal cells undergo H2B turnover after fusing with the epithelial syncytium. Thus, histone degradation may be a widespread mechanism governing dynamic changes of the epigenome.
Diagnosis of the state of activity of the united territorial communities of Odessa region and analysis of the development of their territories
Authors:   Odessa National Polytechnic University, Balan Oleksandr , Dobrіanska Natalia ,   Odessa National Polytechnic University, Serkal Svetlana ,   Odessa National Polytechnic University
Published: August 2023

This article analyzes the current state of development of the united territorial communities of Odessa region. The factors influencing the efficiency of development of the territories of rural united territorial communities are investigated and characterized. The activity of united territorial communities, the share of the population, incomes and expenses per capita, expenses for the maintenance of the management staff and the ratio of expenses for the maintenance of the management staff with the amount of income of the general fund are analyzed. The estimated number and total population in the groups of united territorial communities of Ukraine, formed a rating of the level of use of socio-economic potential. Problems and prospects of development of territories of united territorial communities as preconditions of achievement of their ability are defined.
Methods for forming and improving corporate culture at public enterprises
Authors:   Odessa National Polytechnic University, Hratsiotova Hanna , Stepanova Anna ,   Odessa National Polytechnic University
Published: August 2023

This article examines the phenomenon of corporate culture in state enterprises, considers the general methods of its formation, identifies the main principles on which the organizational culture of the enterprise in modern society, identifies a list of functions, given the need for corporate culture, explores the factors due to which can improve the development of organizational culture in the future, considered the classification of corporate culture, formed over a long period of time since its inception, studied the relationship of corporate culture with other sciences, identified the main factors of formation, development and improvement of organizational culture at state enterprises.
Transitional changes in enterprise management systems and their impact on the innovative potential of the enterprise
Authors:   Odessa National Polytechnic University, Svinarova Hanna
Published: August 2023

The article is devoted to the theoretical and applied principles of the evolutionary development of the enterprise management system and the transitional changes that accompany this process. The main stages of paradigmatic shifts in the economy and their impact on changes in the enterprise management system are considered. A qualitative description of the main stages of paradigm shifts and transitional changes in management systems, which affects the innovation potential of the enterprise. The scheme of gradual transformation of the enterprise management system under the influence of innovative changes is offered.
Theoretical and Methodological Basis for Non-Financial Reporting Preparation regarding Socially Responsible Activities of an Enterprise during the COVID-19 Pandemic
Authors:   Odessa Polytechnic State University, Filyppova Svitlana , Selivanova Natalіа ,   Odessa Polytechnic State University, Fraiman Anastasiia ,   Odessa Polytechnic State University
Published: August 2023

This article examines the theoretical and methodological basis for nonfinancial reporting preparation regarding socially responsible activities of an enterprise during the COVID-19 pandemic. The groups of tools concerning the management level of socially responsible activities of the enterprise are generalized. The main features and main differences of financial and nonfinancial reporting are identified. The developed algorithm for compiling non-financial reporting and the content of its main sections in terms within quarantine measures of the enterprise during the COVID-19 pandemic are highlighted. The form of a monthly report for management accounting and an extract from the Order on Accounting Policy on the Actual Expenses of Socially Responsible Activities within quarantine activities are proposed.
International Market of Tourism Services: State and Trends of Innovative Development in the Conditions of Global Restrictions
Authors:   Odessa Polytechnic State University, Prodius Yuliia , Kovalenko Albina ,   Odessa Polytechnic State University, Vlaieva Alina ,   Odessa Polytechnic State University
Published: August 2023

The article analyzes the development trends of the tourism industry in the context of globalization, widely available information, political and economic instability. The characteristics of the international market of tourism services are considered. The significance and functions of international tourism are presented. The issues of international cooperation in the field of tourism are also analyzed. Factors of the international market development of tourism services are allocated. The factors that will determine the geography of tourist flows and destinations in the coming years are listed, and trends should be taken into account for creating and improving any strategy for tourist destinations development.
Theoretical Features of SME Internationalization
Authors:   National University of Kyiv-Mohyla Academy, Voloshyn Andrii
Published: August 2023

Globalization is one of the key features of today. Most economies are open and therefore economic agents are exposed to external influences, which can be manifested through exports, imports and competition. The main issue of the article is how an enterprise in the SME sector should carry out the process of internationalization based on available resources and the economic system of the country in which it operates. The main theoretical models of internationalization are considered in the article and their comparison with the possibility of application in the Ukrainian realities is made.
Development of Stevidor Enterprises as One of the Means of Improving the Economy of The Region
Authors:   Odessa Polytechnic State University, Zamlynskyi Viktor , Yakovenko Oleksandra ,   Odessa Polytechnic State University
Published: August 2023

The article considers the world trends of the maritime transport complex, analyzes the current state and directions of development of stevedoring companies in Ukraine, aimed at strengthening the competitive advantages of service providers, identifies the specifics and current issues of assessing their activities. The issue of building port-industrial clusters with modern transport logistics is relevant today, as the development of trade and financial ties in the country and abroad forces countries to actively increase capacity and be constantly open to communications and trade offers. The paper identifies the main features of port financing, explores the prospects for the development of seaports and proposes a roadmap for the effective development of port infrastructure. A stevedoring company management structure is also proposed.
International security in the aspect of the megaregionalism development and integration in the APAC
Authors:   Simon Kuznets Kharkiv National University of Economics, Naumik-Gladka Kateryna , Harkusha Vladyslava ,   Simon Kuznets Kharkiv National University of Economics
Published: August 2023

The Asia-Pacific region is the world's largest "macro-region", home to about half the world's population and accounts for about the same share of the world economy. Some countries in the region have significant global influence. The character of the modern world is increasingly defined and formed around this region. One of the largest projects in the region is the development of a megaunion of the Regional Comprehensive Economic Partnership. The development of the RCEP project aims to lead the integration processes in the Asia-Pacific region. The article examines the slow flow of the initiative from ASEAN to China, the conflict of interests between the United States and China. The processes of transformation of the order of hegemony and formation of the regional version of the multipolar system of relations are described.
Information Protection of Business Processes in the Digital Economy Conditions
Authors:   Odessa Polytechnic State University, Budoratska Tetiana , Kovalova Hanna ,   Odessa Polytechnic State University, Trofymenko Iryna ,   Odessa Polytechnic State University
Published: August 2023

This article is dedicated to the problem of information protection of an enterprise business processes, which is relevant in the digital economy. The research paper proposes functional models of subsystems that form an integrated protection model. The analysis of the business processes structure made it possible to form the necessary system of information security indicators that directly affect the entire structure organization for protection from both external and internal threats. Mathematical formulae are given for determining the generalized indicator for assessing the quality of the protection structure and the security factor of the business process. The characteristics of the complex indicator values of information security and their relationship with the general status of enterprise security are presented. The options for assessing protection, their relationship with models at the level of integrated evaluation are determined.
The impact of cycling infrastructure on consumers' perceptions of bicycle transport
Authors:   National Technical University of Ukraine ", Gnitetskyi Ievgen ,   Igor Sikorsky Kyiv Polytechnic Institute", Tsarova Tetiana ,   National Technical University of Ukraine "Igor Sikorsky Kyiv Polytechnic Institute", Lymar Olena ,   National Technical University of Ukraine "Igor Sikorsky Kyiv Polytechnic Institute"
Published: August 2023

The aim of the article is to research the influence of developing the cycling infrastructure on the consumer's choice of bicycles as an alternative to eco transportation. The article talks about the problems and perspectives of developing a cycling infrastructure. An analysis of reasons was conducted in regards to the consumer's choice using bicycles as means of everyday transportation. Also, a positive experience in developing the cycling infrastructure in leading European countries was discussed. The article researched key requirements for developing the cycling infrastructure and identified basic criteria of its development, in particular in Kyiv city.
Theoretical and methodological principles of evaluating the efficiency of use of fixed capital by mechanical engineering enterprises
Authors:   Odessa Polytechnic State University, Yepifanova Irina
Published: August 2023

The research paper notes that the efficiency of the use of fixed capital is one of the basic criteria of the performance of a mechanical engineering enterprise, which necessitates its detailed study and evaluation. Peculiarities of evaluating the efficiency of use of fixed capital of mechanical engineering enterprises are investigated. A thorough analysis and generalization of current methodical approaches to evaluating the efficiency of the use of fixed capital by the enterprise is carried out. The basic criteria of evaluating the efficiency of use of fixed capital by mechanical engineering enterprises are determined. The author’s concept of the modern methodology for evaluating the efficiency of the use of fixed assets by mechanical engineering enterprises is presented graphically, including: object, subject, goals and objectives, principles and functions, methods and criteria for evaluating the efficiency of the use of fixed capital by mechanical engineering enterprises. The purpose and tasks of further scientific research are substantiated, which consist in the practical use of the proposed methodology for real evaluation of the efficiency of the use of fixed assets of the operating mechanical engineering enterprises and their forecasting in order to ensure their strategic development.
Strategic aspects and the mechanism of organizational optimization business processes of entrepreneurial structures in the context of growing socio-economic turbulence
Authors:   Odesa Polytechnic State University, Bavyko Oleksandr , Bavyko Olena ,   Odesa Polytechnic State University
Published: August 2023

The growth of socio-economic turbulence is expressed in unpredictable fluctuations of the economic conjuncture and deterioration of conditions in the business environment. This necessitates the formation of a mechanism for optimizing business processes of entrepreneurial structures, which will preserve economic efficiency. The experience gained during the COVID-19 pandemic indicates a reduction in strategic planning timeframes to 1-2 years and an increase in the importance of digital monitoring of changes in the external environment. The digitalization of business processes acts as a technological basis for their organizational optimization, subject to the principles of strategic management and aimed at reducing their cost in the direction of horizontal and vertical compression based on automation and combining of sub-processes.
Space of conflict situations in the organizational-technological system of high-tech production
Authors:   Odesa Polytechnic State University, Zakharchenko Vitaliy , Yermak Svitlana ,   Odesa Polytechnic State University
Published: August 2023

The article proposes a methodical approach to solving the problem of creating organizational and technological systems in high-tech production, which are designed to ensure sustainable action to implement the objective function of such systems, as well as functional systems of a higher level of hierarchy for different purposes. Evaluation of the effectiveness and validity of the main feasibility studies for such systems used to provide appropriate functional systems in conflict, is carried out at the appropriate level of typing - the level of a typical conflict situation, which is a formalized aggregate procedure for replacing the entire list of source data by their typical representatives. The proposed methodological approach and block diagram of the algorithm for selecting typical situations create opportunities for the formation of a methodology designed to formalize the typification of conflict dynamics during the operation of functional subsystems with a high degree of objectivity and build a reliable strategy for assessing efficiency and justification of organizational and technological requirements. systems.
Analysis of Financial Management Issues for the Development of Territorial Communities by Assessing Their Investment Potential
Authors:   Odesa Polytechnic State University, Kovalova Olena , Burlaka Olha ,   Odesa Polytechnic State University
Published: August 2023

The article analyzes the effectiveness of financial management of the development of territorial communities in terms of assessing their investment potential. The problems and directions of solving the tasks are given, which is indicated in the "Concept of reforming local self-government and territorial organization of power". The state of the revenue side of local budgets in Ukraine as a whole and, in particular, in the Odesa region is analyzed. Sources of income and trends in the structure of funding for the period 2018-2021 are considered.
Neuromarketing in the system of modern commodity science: the influence of packaging design on consumer behavior
Authors:   National University ", Vasiuta Viktoriia ,   Yuri Kondratyuk Poltava Polytechnic", Arkhipova Anastasia ,   National University "Yuri Kondratyuk Poltava Polytechnic"
Published: August 2023

The article analyzes consumer behavior in terms of existing diversity and availability of goods. The authors noted the importance of the interaction of marketer and designer in creating packaging. The main factors influencing potential buyers, the motives that guide them when making purchasing decisions are identified. The role of packaging in the promotion and sale of products is analyzed, its functions are revealed. The basic requirements, criteria of design of packing are allocated. The authors substantiate the importance of investing resources in the process of its creation. The influence of the color scheme of the package on the physiological and mental state of a person is characterized. It is important to take into account the emotional impact of colors on consumer decisions about buying goods. The place of neuromarketing in modern commodity science is determined, its significance is revealed and the main characteristics are formulated. The essence of visual merchandising is considered. The directions of further research on this topic are indicated.
The Main Factors for Educational Tourism Market Development of Ukraine
Authors:   Odesa Polytechnic State University, Hutareva Yuliia , Kovalenko Albina ,   Odesa Polytechnic State University
Published: August 2023

The article deals with the main factors that influence the Ukrainian educational tourism market development. The place of educational tourism of Ukraine in the international market of educational tourism has been determined. The main motives of educational tourism of Ukraine have been investigated. Specific features of educational tourism and types of educational tourism have been determined. The authors’ definition of educational tourism as an economic category has been formulated. The authors’ model of educational tourism, based on the notions of "education" and "tourism" has been developed. The most important prerequisites that determine the circumstances of the educational tourism market development have been characterized. The actual problems of educational tourism of Ukraine have been allocated. The ways for improving educational tourism of Ukraine and recommendations for improving this category of tourism have been developed.
Methodological substantiation of the tools of analysis of financial statements during the transition to the new technological institution
Authors:   Odesa Polytechnic State University, Zakharchenko Vitaliy , Metil Tetiana ,   Izmail State Humanities University
Published: August 2023

The article provides a methodological justification for assessing the state of financial management of the enterprise using the category of "technological way". The paper presents a conditional view of the sedentary technological structure in the form of: axes as a group of interconnected new industries, technologies, enterprises; disk as a manufacturing sector that unites large industrial enterprises that produce competitive serial products; Tires are mainly small and medium-sized enterprises that generate the latest products and technologies and undergo trial marketing. The paper considers the structure of the axis of the technological structure of financial management of the enterprise, as well as providing financial instruments – financial assets and financial liabilities.
The role of innovation management in managing the competitiveness of enterprises in world markets
Authors:   V. N. Karazin Kharkiv National University, Leonenko Karyna , Liashevska Viktoriia ,   V. N. Karazin Kharkiv National University, Nosova Olga ,   V. N. Karazin Kharkiv National University
Published: August 2023

The article examines innovation management as a key factor in the formation of the competitiveness of industries and enterprises in world markets. The essence of the concepts is analyzed: innovation, innovative activity and competitiveness. The structure of innovation potential and its interrelation with other potentials of the economic entity are determined. For the criterion of innovative development, the problems of managing the competitiveness of an enterprise were considered and investigated. The features of the processes arising on the basis of the proposed model for the formation and implementation of the innovative potential of an enterprise, as well as its transformation into innovative capital, are indicated. The principles of enterprise competitiveness management have been determined. Compliance with the principles of the competitiveness management method based on the knowledge economy has been proved.
Intratumour microbiota modulates adrenocortical cancer responsiveness to mitotane
Authors: Cantini Giulia , Niccolai Elena , Canu Letizia , Di Gloria Leandro , Baldi Simone , Propato Arianna Pia , Fei Laura , Nannini Giulia , Puglisi Soraya , Nesi Gabriella , Ramazzotti Matteo , Amedei Amedeo , Luconi Michaela
Published: August 2023

The infiltrating microbiota represents a novel cellular component of the solid tumour microenvironment that can influence tumour progression and response to therapy. Adrenocortical carcinoma (ACC) is a rare and aggressive endocrine malignancy for which mitotane (MTT) treatment represents the first-line therapy, though its efficacy is limited to a therapeutic window level (14–20 mg/L). Novel markers able to predict those patients who would benefit from MTT therapy are urgently needed to improve patient’s management. The aim of our study was to evaluate the presence of intratumoural bacterial microbiota DNA in 26 human ACC tissues vs 9 healthy adrenals; moreover, the association between the relative bacterial composition profile, the tumour mass characteristics and MTT ability to reach high circulating levels in the early phase of treatment, were explored. We found the presence of bacterial DNA in all adrenal samples from both tumours and healthy cortex specimens, documenting significant differences in the microbial composition between malignancy and normal adrenals: in detail, the ACC tissues were characterised by a higher abundance of the Proteobacteria phylum (especially the Pseudomonas and Serratia genera). In addition, the Proteobacteria’s low abundance was negatively associated with tumour size, Ki67 and cortisol secretion. MTT levels reached higher levels at 9 months in ACC patients with high abundance of Proteobacteria, Pseudomonas and Serratia and with low abundance of Bacteroidota, Firmicutes and Streptococcus. These findings are the first indication that human ACCs are characterised by infiltrating bacteria and their specific abundance profile seems to influence the increase in circulating MTT levels at 9 months.
Interaction of rivanol with molecules of deoxyribonucleic acid (DNA) sorbed onto nanocrystalline titania surface
Authors:   Chuiko Institute of Surface Chemistry of National Academy of Sciences of Ukraine, Markitan O. V. , Vlasova N. N. ,   Chuiko Institute of Surface Chemistry of National Academy of Sciences of Ukraine, Sheludko Y. V. ,   Kukhar Institute of Bioorganic Chemistry and Petrochemistry of National Academy of Sciences of Ukraine
Published: August 2023

Сreation of new therapeutic materials based on nucleic acids encourages the combination of the latter with materials capable of adsorbing them. One of the most promising materials for such purposes is nanocrystalline titanium dioxide due to its low toxicity, stability of its physical and chemical parameters, and high biocompatibility. Accordingly, understanding the nature of the interaction of the surface of titanium oxide with biologically active substances is a very important issue. It is also always a relevant question whether the biopolymer immobilized on the surface of a solid remains capable of serving as a reservoir for drug delivery or a tool for the treatment of a particular disease. The aim of the work was to investigate the interaction of the biologically active substance rivanol with the surface of DNA-containing titanium dioxide. It has been found that prior adsorption of deoxyribonucleic acid on the surface of titanium dioxide does not prevent its interaction with rivanol, which was confirmed by the methods of electron spectroscopy, atomic force and scanning electron microscopy. The mode of interaction of rivanol with deoxyribonucleic acid depends on the ratio of their concentrations and can be either intercalated or semi-intercalated, and electrostatic. Based on the calculated thermodynamic characteristics, the process of interaction of deoxyribonucleic acid adsorbed on the surface of a solid carrier is arbitrary and occurs by an ion exchange mechanism. These hybrid organo-mineral sorbents can serve as model structures for research in biotechnological fields, be used for the development of new methods of drug or gene delivery, reservoir systems at a molecular level, and serve as biocompatible carriers. The creation of organo-mineral sorbents, which combine nucleic acids and metal oxides, contributes to the stabilization of such systems and expands the scope of their possible application in medicine and biotechnology, increasing their target specificity.
Thermodynamics of the ion exchange of Ca2+ and Sr2+ cations on Na-form of natural clinoptilolite
Authors:   A.V. Dumansky Institute of Colloid and Water Chemistry of National Academy of Sciences of Ukraine, Krysenko D. A. , Таrasevich Yu. A. ,   A.V. Dumansky Institute of Colloid and Water Chemistry of National Academy of Sciences of Ukraine, Demchenko V. Ya. ,   A.V. Dumansky Institute of Colloid and Water Chemistry of National Academy of Sciences of Ukraine
Published: August 2023

The adsorption and direct calorimetric studies of the binary exchange of Ca2+ and Sr2+ cations on the Na-form of low-silica type natural clinoptilolite (Sokyrnytsya, Ukraine) were performed. The ion exchange of Ca2+ and Sr2+ cations on the Na-form of natural clinoptilolite was studied under static conditions at a solid to liquid phase ratio of 1 : 100 and a constant ionic strength of the solution of 0.1. The integral heats of ion exchange for these systems were measured using a highly sensitive Tian-Calve microcalorimeter in a special lab-made cell. Also, the ion exchange isotherms and Kielland curves were plotted, and the corrected selectivity coefficients and ion exchange constants were calculated. Changes in the integrated Gibbs free energies, enthalpies, and entropies of the ion exchange of Ca2+ and Sr2+ cations on the Na-form of clinoptilolite were calculated in entire range of the substitutions of the exchange complex. The thermodynamic parameters of incomplete ion exchange were analyzed in terms of the crystal structure of the zeolite. In addition, the state of exchangeable cations in the channels of clinoptilolite was described in detail. It is shown that structural heterogeneities of cation-substituted forms of clinoptilolite are clearly reflected in the dependence of thermodynamic functions on the degree of exchange, and significant differences are observed between the exchange of Ca2+ and Sr2+ cations that could not be described by standard thermodynamic values. Although the isotherms of ion exchange have a convex shape, the Na-form of clinoptilolite does not show any thermodynamic affinity to Ca2+ cations. This ion exchange reaction is accompanied by positive enthalpy changes in all range of substitutions of the exchange complex. At the same time, thermodynamic selectivity toward Sr2+ cations was observed for 40 % of the zeolite exchange centers, and the exchange is accompanied by minor exothermic effects in the range of small substitutions, and the ion exchange isotherm has σ-like form. In general, the thermodynamic affinity of the Na-form of clinoptilolite to the studied metal ions under conditions of incomplete exchange is ordered as following hydration energy trends in the case of the lyotropic properties among alkaline earth metals. Thus, the experimental thermodynamic characteristics of ion exchange equilibria could be a reliable support for the practical using of natural clinoptilolite.
Solid-phase synthesis of MINi2MIV(PO4)3 compounds (МI – Li, Na, K; MIV – Ti, Zr, Sn)
Authors:   Taras Shevchenko National University of Kyiv Ukraine, Petrenko O. V. , Lavrik R. V. ,   National University of Life and Environmental Sciences of Ukraine, Galimova V. M. ,   National University of Life and Environmental Sciences of Ukraine
Published: August 2023

Double phosphates compounds may possess catalytic, magnetic, electrophysical, non-linear optical properties and are used as monocrystals or polycrystals, ceramics etc. The tailor-made synthesis of double phosphates of alkali and multivalent metals is the basis for the in-depth research and investigation of physical and chemical properties, composition and structure of the compounds to be used for the development of new materials for multi-purpose use. Episodic syntheses of compounds MI3MIІMIV(PO4)3, MI2MIIMIV(P2O7)2, MI2MII(PO3)4 and МІMІІ4(РО4)33 (where МI – Li, Na, K; МIІ – Mn, Co, Ni; MIV – Zr), were made from various starting materials by the sintering method. After all, the selection of compounds for the synthesis of compounds of this type is a rather difficult task, often impossible. A systematic approach to the selection of starting reagents, temperature regime, interaction time between components are factors that can be adjusted and operated to achieve the target. The work used the method of solid-phase synthesis, after working out the synthesis method on the “model” Na2NiZr(P2O7)2. The synthesis was carried out starting from Na2CO3, NiO, CoO, ZrO2, ammonium hydro- and dihydrogen phosphate. The synthesis of compounds was carried out based on preliminary derivatographic studies of the passage of processes according to the corresponding reaction schemes. Completeness of synthesis stages was monitored at all stages using physico-chemical research methods. The DTA method confirmed the possibility of solid-phase synthesis of complex phosphate compounds that contain several transition metals – MINi2MIV(PO4)3 (where МI – Li, Na, K; MIV – Ti, Zr, Sn). The optimal temperature conditions for obtaining a number of phosphate compounds based on various starting substances for their synthesis have been found. The synthesized compounds were investigated by X-ray diffraction, DTA and IR spectroscopy, and their complete chemical analysis was carried out. The influence of a number of factors on the conditions of production of phosphate compounds of the MINi2MIV(PO4)3 (where МI – Li, Na, K; MIV – Ti, Zr, Sn) has been found. It can be assumed that the ionic conductivity in the synthesized compounds is of the “NASICON” type, and therefore the synthesized substances can be used as functional materials with valuable electro-physical properties.
Esource-saving continuous optical control of liquid metal temperature in metallurgy of energy machine building
Authors:   General Energy Institute of NAS of Ukraine, 172, Antonovycha St., Kyiv, 03150, Ukraine, Zhukov Leonid , Petrenko Dmytro ,   Physico-Technological Institute of Metals and Alloys of NAS of Ukraine, 34/1, Vernadskogo Blvd., Kyiv, 03142, Ukraine
Published: August 2023

The article is devoted to the problem of the most effective and non-alternative continuous optical temperature control of metallurgical aggregates in machine building metallurgy. The aim of the article is to develop and investigate the technologies of continuous temperature control on the base of classical and spectral (multicolor) thermometry. To achieve thе aim, the next methods have been used: analysis of literature sources; experimental investigations of influence regularities of sighting zones, time of tapping, intensity of mixing and liquid metal temperature on one color radiation temperature of liquid metal in visible and infrared spectrum ranges under industrial conditions; statistical processing of the results of direct and indirect measurements with their errors estimation. It has been found the main role of thermometry in the metrological support structure of metallurgical plants. The production volumes of world machine building metallurgy have been analyzed, particularly, the part of metallurgy of energy machine building in it. Metallurgical equipment to be used for liquid metal obtaining and treatment has been classified from thermometric position. The stability of radiation characteristics of liquid metal in cupola, arc and induction furnaces has been investigated under conditions of different impact factors. The methodical errors of optical temperature measurements of liquid metal during tapping from cupola and arc furnaces on the base of classical energy thermometry have been estimated. In special determined сases these errors don’t exceed 1,0–1,5% with confidence level 0,997. Under another conditions these errors reaches 8% and this fact stimulates transition to the spectral thermometry. With the use of modern elemental base, the technologies of spectral measurements of temperature and emissivity have been developed. The technologies include: symmetric-wave, two-color compensative, as well as based on nonlinearity equation of emissivity spectral distribution. The temperature measurement errors of new technologies are lower than the same ones of known spectral, as well as classical energy and spectral ratio thermometry in 2,3; 11,7–20,0 and 6,1–7,6 times. Keywords: metallurgy of machine building, continuous optical temperature control, cupola furnace, arc furnace, classical and spectral thermometry.
Perceived efficiency and local consensus as factors shaping medicinal plant knowledge
Authors: Sousa Daniel Carvalho Pires , Ferreira Júnior Washington Soares , Santos Yasmim Antonio Costa dos , Moura Joelson Moreno Brito de , Albuquerque Ulysses Paulino
Published: August 2023

Environmental perception goes through physiological, psychological, and cultural filters and can influ- ence the selection and usage of species. Additionally, sharing cultural information is a crucial social strategy for our species’ survival. From this standpoint, knowledge that aligns with the local context is typically the most widely "expressed" and/or "replicated" by individuals. Building upon this premise, our objective was to investigate whether knowledge about local medicinal plants is influenced by certain adaptive factors, such as perceived efficacy, perceived availability, and perceived frequency of diseases. The study was conducted with 73 individuals from five rural communities in Vale do Catimbau Na- tional Park, Buíque, Pernambuco, Brazil. A free list of medicinal plants and their therapeutic uses was employed. Using these free lists, we employed a salience index to determine consensus within the local diversity. We employed a generalized linear model with a binomial distribution to ascertain whether perceived efficacy, perceived availability, and perceived disease frequency account for the local consen- sus. Of the three variables analyzed, only perceived efficiency explained the local consensus on the use of medicinal plants (p < 0.002). This result indicates that perceived efficiency is the key factor deter- mining the most popular medicinal plant when requested for memory recall, regardless of the perceived availability of the plant or the perceived frequency of diseases it treats. However, looking through the evolutionary perspective, the main question is to understand whether this factor is the only determi- nant in explaining the nature of the generation of medicinal plants’ salience, or if other ’cofactors’ of the social-ecological systems act together in an important way to guide this process as well.