bluuebunny/crossref_metadata_2025 huggingface dataset:
Study of Level of Understanding about the Ergonomics to be Followed in the Rural and Urban Population on Prevention of Various Musculoskeletal Problems
Authors: Desai Sakshi Satyajeet , Anandh S.
Published: May 2024

Background: Ergonomics is a vague concept to learn and applying it to day-to-day life will make the work easier with less effort. Urban and rural populations both have different types of work strategies. By understanding ergonomics, modifications will be made, preventing musculoskeletal problems. This research aims to study the level of understanding of the ergonomics to be followed in rural and urban populations for the prevention of various musculoskeletal problems. Objectives: The objectives are to check the awareness level related to ergonomics among rural and urban populations using a self-made questionnaire and find out the common musculoskeletal problems prevailing and possible risk factors related to them. Methods: This was a convenience sampling method that consisted of 91 participants included in this study. 45 from rural and 46 from urban populations were selected based on inclusion and exclusion criteria. The questionnaire was made on the basis of different aspects, which will determine the level of understanding overall. The questionnaire was provided online and in offline mode too. The level of understanding was checked for each population based on responses. Results: Based on the statistical analysis, it was found that the urban population has a higher level of understanding and prevention strategies as compared to the rural population. Conclusion: Findings showed that ergonomics was a new term for the participants, but knowledge and understanding were seen more in urban participants than rural participants.
Study of Knowledge About the Developmental Milestones of Children in Primiparous Mothers
Authors: Anushka Desai , Srinivasan Anandh
Published: May 2024

Background: Following the pivotal moment of childbirth, challenges may arise as children with developmental issues often experience delayed attention. Contributing to these delays is a lack of awareness regarding developmental milestones. Primiparous mothers, being primary caretakers, play a significant role in the timely identification. It is essential to educate them about developmental milestones enabling them to monitor their child’s growth trajectory and promptly address any delays. Emphasising the importance of ruling out developmental issues during the initial stages is imperative. Objective: To seek knowledge regarding developmental milestones at different stages among primiparous mothers. Materials and Methods: 95 participants from Ahmednagar district participated in this study. The selection of study subjects was based on criteria for inclusion and exclusion and consent in written form was obtained beforehand. The research included primiparous mothers. They were interviewed using a structured questionnaire based on children’s development milestones. Following that, the data was collected and appropriately analysed. Results: It was found that 42.11% of primiparous mothers had a good knowledge of the developmental milestones of their babies. Most of the knowledge (54.38%) was found in the initial milestones section, while the least amount (33.15%) was found in language. Conclusion: Among all the developmental domains, primiparous mothers have a thorough understanding of the initial milestones (54.38%) and the most limited understanding of language development (33.15%).
6 Şubat 2023 Depremleri ve Saha Gözlemlerine Dayalı Bina Hasarları Hakkında Ön Değerlendirme
Authors: Yenidoğan Cem
Published: May 2024

6 Şubat 2023 depremleri geniş bir coğrafyada hissedilmesi ve yaratmış olduğu yıkım ile son yüzyılın en yıkıcı depremleri arasında yerini almıştır. 6 Şubat depremlerinde oluşan karmaşık kaynak özellikleri, deprem kayıtlarının karakterizasyonu, afet bölgesi ilan edilen 11 şehir için yürütülen hasar tespiti çalışmaları mühendisler için çok önemli veriler barındırmaktadır. Hazırlanan bu çalışmanın amacı depremin ikinci gününden itibaren periyodik bir şekilde afet bölgesi ilan edilen 11 ilde saha gözlemleri özelinde 6 Şubat depremlerinin sismo-tektonik, güçlü yer hareketi kayıtlarının özellikleri, binalarda ortaya çıkan hasar dağılımı ve karakteristik özellikleri hakkında bulguları paylaşmaktır. Depremden etkilenen bölgede ağır hasarın yoğunlaştığı illerde elde edilen verilere yönelik tespitler bu çalışma kapsamında kısaca açıklanmaya çalışılmıştır. Derlenen veriler yetkili kurumlar tarafından paylaşılan raporlar, duyurular ve yürürlükte olan deprem yönetmeliği dikkate alınarak bölgede hakim olan bina tipi mevcut yapı envanterinden faydalanarak elde edilmiştir. Kırsal kesimde ve şehir merkezlerinde hasar dağılımı incelendiğinde tescilli kültür varlığı statüsündeki yığma binalar dışında hakim yapısal sistemin şehir merkezlerinde mühendislik hizmeti almış, orta yükseklikte betonarme binalar olduğu, kırsal kesimde ise mühendislik hizmeti almamış, az katlı betonarme, karma veya yığma tipi binalar olduğu belirlenmiştir. Hasar tespitinde geçmiş deneyimlerle kıyaslandığında akademisyenler tarafından verilen eğitimlere katılmış olan saha ekiplerinin göreceli olarak daha hızlı ve titiz bir çalışma ortaya koydukları görülmüştür. Geleneksel binalara ek olarak hastane binalarına yönelik çalışmalarda deprem yalıtımı uygulanmış binalar ve geleneksel binaların kıyaslanması bir sistematik içerisinde gerçekleştirilmiştir.
The Directions for Improving the Surface Wastewater Treatment Facilities
Authors: Alekseev E.V. , Sidorova T.S.
Published: May 2024

Prospective directions for increasing efficiency of the drains by improving the systems for collection, disposal and treatment of surface wastewater have been considered. The design and technological features of treatment facilities in operation have been analyzed. The significant shortcomings have been identified, as a result of which the quality of purified water discharged into water bodies, declared by manufacturers, is reduced and the operation is complicated. Promising directions for resolving the identified problems have been recommended: targeted formation of surface wastewater flows, increasing the engineering and technological level of mono-block structures, the use of modern structural materials, providing the possibility of remote monitoring and control of the technological process, as well as timely routine maintenance.
Introduction: East-Central and Central-East Europe as an Imagined Space for Shakespeare
Authors: Havlíčková Kysová Šárka , Mišterová Ivona
Published: May 2024

The publication of the issue was supported by the International Visegrad Fund, project no. 22210007, titled “Crossing Borders with Shakespeare since 1945: Central and Eastern European Roots and Routes.” The project is co-financed by the Governments of the Czechia, Hungary, Poland and Slovakia through Visegrad Grants. The mission of the Fund is to advance ideas for sustainable regional cooperation in Central Europe.
"Henry V": A Report on the Condition of the World
Authors: Gibińska Marta
Published: May 2024

The central interest of the paper is concentrated on an online production of Henry V in 2020. The project is based on a new Polish translation by Piotr Kamiński and produced by Dariusz Rosiak, a journalist, as one of his regular Reports on the Condition of the World published on YouTube. Realised as a reading performance by three actors in front of an empty row of chairs, the production brings an innovative and revealing interpretation of the play, breaking new ground in the Polish reception of Shakespeare’s histories.
The paper offers a brief review of the presence of history plays in Polish reception and introductory information on Rosiak’s YouTube channel and Kamiński’s translation as a background to a critical analysis of the production and its relevance to the here and now of our world.
Dramaturgy of "Hamlet"(s) in Czech Theatre between 2000 and 2023
Authors: Drozd David
Published: May 2024

The paper focuses on five Czech productions of Hamlet that attracted the most critical and public attention between 2000 and 2023. Namely, the productions directed by Miroslav Krobot (2006), Jan Mikulášek (2009), Daniela Špinar (2013), Michal Dočekal (2021) and finally the most recent version by Jakub Čermák (2022). All five performances could be seen as contemporary reinterpretations of a classical text using a (post-)modern stylistic approach, as examples of post-millennium Hamlets. The paper discusses dramaturgical choices (such as the conceptualisation of the ghost, the mousetrap scene, or the character of Fortinbras) in order to identify and analyse possibilities for interpreting Hamlet as a political drama in the context of Czech performance tradition and the current political situation. The results show that performances generally present variations of Hamlet as a family drama, foregrounding different issues of memory and body, while the political reading is obsolete.
Framing Polish-Jewish Relations Through Shakespeare in Post-war and Contemporary Polish Theatre
Authors: Kowalski Tomasz
Published: May 2024

The paper aims to analyse how the staging of Shakespeare’s texts in post-war and contemporary Poland reflected the indifferent and hostile attitudes of Poles towards Jews, particularly during the Holocaust, and the distortions and gaps in the collective memory regarding the events. In the first part, the author focuses on Hamlet Study (dir. Jerzy Grotowski) performed in 1964 by Laboratory Theatre of 13 Rows in Opole, which is symptomatic of silencing the matter during the communist period. The second part draws from the statement of Jan Ciechowicz, a Polish theatre historian, who claimed that “the Holocaust killed Shylock for Polish stage.” While verifying it, the author analyses selected aspects of three productions directed by Krzysztof Warlikowski (The Tempest (2003), The Merchant of Venice (1994) and The African Tales by Shakespeare (2011)) and juxtaposes them against the background of the changes in collective memory. He argues that the most cogent productions concerning Polish attitudes towards Jews are those that position the audience as witnesses of the acts of re-enacted violence and thus provoke an affective response.
Geneza i rola drzew w mitologii japońskiej w świetle Kojiki i Nihongi
Authors: Wesołowski Dawid
Published: May 2024

Animistic cults and religions are characterized by belief, that every part of the world, both alive and inanimate, contain soul or spirit. One of those is Japanese indigenous religion — shintō. The world of Japanese mythology revolves around anthropomorphic deities — kami and countless spirits that manifests in fauna, flora and in various phenomena of nature. Description of creation of the world and all its elements was written down in chronicles Kojiki and Nihongi. Cosmogony in Japanese mythology equals teogony and thanks to that it is possible to analyze origin of trees, as well as genealogy of deities responsible for that part of the flora. By studying texts of chronicles in Polish and English translations along with Japanese original I would like to show mythical beginnings of specific trees in Japan — first ancestor and origin of specific species — and role they played in history of a mythical heroes. Among others, paper presents theory of origin of sakaki and also a potential identification of the uncanny tree that grew near Uki river.
Motywy zwierzęce w Apokalipsie św. Jana
Authors: Korabik Kamila
Published: May 2024

This article is a discussion on the symbolism of the animals that appear in the Apocalypse of St. John, and of the part they play. Motives of the Satan and the lamb have been analyzed in special way. There is also a reference to how the particular species of the animals of the Apocalypse evolved throughout the pages of the Old Testament. The reference is supported by properly chosen citations.
Symbolika laski marszałkowskiej w świetle zachowanej ikonografii i literatury
Authors: Mielnik Paulina Anna
Published: May 2024

This article is an attempt to answer a question how does the Marshall’s cane, shown from different scientific prospects, includes allegorical meaning. As the attribute of Marshall’s office it was an important communicative item. Alongside with a written word, verbal system as well as a picture, sign and symbol were means of transmission for illiterate community. The cane is the emblem of power and refinement, equipped in a rich symbolism, empowers and constructs the dignity of Marshall’s office. Fauna and flora motives visible in its complex system of symbolism emphasizes additionally its value.
Wobec tajemnicy istnienia: o sposobach doświadczania świata w utworze Józefa Weyssenhoffa Soból i panna
Authors: Pietrasik Patrycja
Published: May 2024

The aim of the article is to show what are the characters of Joseph Weyssenhoff’s Sable and the lady perceptions of the world. It addresses the specificity of the descriptions of nature, which undoubtedly affect the characters of the novel. A great part of the novel is devoted to the relations between humans and nature, which indicates that there exists a special bond between them. On the basis of the reflections mentioned in the novel we observe a sort of connection between the environment and human life. We can distinguish similarities in terms of character creation and their surroundings, as well as highlighting important elements such as personification of the descriptions of nature and animals, the influence of nature on the feelings and behavior of the characters, which often varies along with changes of their mood; poetic thoughts influenced by the contemplation of nature, the presence of fauna and flora in the most important events of the characters’ lives.
Empowering Rural Women Through Handloom Micro Enterprises: A Case Study of Udalguri District, Assam
Authors: Deka P. , Barman P. , Rabha H. , Bora P. , Borah D. , Das P.
Published: May 2024

Background: The handloom industry in Assam showcases a remarkable diversity that extends across both rural and urban areas which serves as a supplementary source of income for numerous households in the state. Nalkhamara, a village in Udalguri district of Assam became the workplace for a group of 15 most talented weavers who grouped to form a SHG called Rampar Self Help Group. But unfortunately, they faced significant challenges due to limited resources and absence of marketing organizations. In order to address the issues, the SHG reached out to the KVK, Udalguri for assistance and accordingly, the KVK conducted a demonstration on capacity building of women weavers to enhance their skills in weaving and provided guidance on modern marketing techniques etc. Hence, the present study was planned with the objectives to analyze the economic impact on weavers before and after KVK intervention, types of products manufactured and the constraints faced by them. Methods: The study has followed the case study method with a total of 15 weavers of Rampar SHG having training under KVK, Udalguri. A pre tested questionnaire was prepared to collect data. To measure the economic impact, parameters like gross cost and return, net return, B: C ratio etc. were considered before and after intervention. To evaluate the problems of weavers, open ended questions were asked. Suitable statistical tools were used to analyze the data. Result: With the intervention of KVK Udalguri, the weavers of the SHG able to earn average annual income between ₹ 13.00 to Rs.15.00 lakhs and could able to produced twenty types of diversified handloom products. The constraints faced by them were like improper time management, high input price, exploitation by intermediaries etc.
Evaluation de la Qualité Physico-Chimique et Microbiologique des eaux de Puits Consommées dans le Quartier Kombé à Brazzaville
Authors: Tchoumou Martin , Louzayadio Mvouezolo Raison Félicien , Malera Kombo Merci Adonaï , Moussoki Nsona Promesse , Ouamba Jean-Maurille
Published: May 2024

Naturellement, les eaux souterraines sont potables de façon générale et devraient être consommées sans aucun traitement préalable. Malheureusement, ces eaux sont soumises actuellement à une forte pression anthropique. Cette étude vise d’évaluer la qualité physico-chimique et microbiologique des eaux de puits consommées dans le quartier Kombé à Brazzaville. Quatre puits ont été identifiés et caractérisés. La caractérisation a montré trois puits équipés des mêmes systèmes de protection et de remontée d'eau et, un seul point de prélèvement diffère des autres par le système de remontée d'eau. Trente-trois paramètres physico-chimiques et neuf paramètres microbiologiques ont été évalués par des méthodes normées et référencées. Les résultats obtenus révèlent du point de vue physico-chimique que, les eaux de puits étudiées sont faiblement minéralisées et tous les paramètres physicochimiques répondent aux normes de l'OMS, excepté le pH, la concentration des ions cadmium, chrome, phosphate ainsi que de la silice dans certains cas. Une seule famille chimique est mise en évidence : les eaux chlorurées sodique et potassique. Malheureusement, ces eaux sont fortement chargées en Escherichia. coli, Salmonella et Shigella, coliformes totaux, Pseudomonas aeruginosa, germes totaux, staphylocoques, levures et moisissures. Elles sont impropres à la consommation humaine et doivent subir quelques traitements préliminaires comme la correction du pH à la chaux et la désinfection à l’hypochlorite de sodium.
Naturally, groundwater is generally drinkable and should be consumed without any prior treatment. Unfortunately, these waters are currently subject to strong anthropogenic pressure. This study aims to evaluate the physicochemical and microbiological quality of well water consumed in the Kombé district of Brazzaville. Four wells were identified and characterized. The characterization showed three wells equipped with the same protection and water rise systems and only one sampling point differed from the others by the water rise system. Thirty-three physicochemical parameters and nine microbiological parameters were evaluated using standardized and referenced methods. The results obtained reveal from the physicochemical point of view that the well water studied is poorly mineralized and all the physicochemical parameters meet WHO standards, except pH, the concentration of cadmium, chromium, phosphate ions as well as than silica in certain cases. Only one chemical family is highlighted: sodium and potassium chloride waters. Unfortunately, these waters are heavily loaded with Escherichia. coli, Salmonella and Shigella, total coliforms, Pseudomonas aeruginosa, total germs, staphylococci, yeasts and molds. They are unfit for human consumption and must undergo some preliminary treatments such as pH correction with lime and disinfection with sodium hypochlorite.
ДЕРЖАВНЕ РЕГУЛЮВАННЯ ЕКОНОМІКИ В УМОВАХ НЕВИЗНАЧЕНОСТІ
Authors: Обелець Т.В.
Published: May 2024

Дослідження присвячене визначенню напрямів державного регулювання економіки в умовах невизначеності високого рівня. У статті проаналізовано загальні збитки та втрати України за сферами економічної діяльності, дефіцит торговельного балансу. У дослідженні окреслено середньострокові перспективи поточного рахунку держави. Також в роботі увагу приділено аналізу доходів, видатків та сальдо зведеного бюджету України, наведений аналіз зміни реального ВВП держави. Порівняння зовнішнього державного боргу та золотовалютних резервів України показує незбалансованість показників. У статті наведено низку чинників, що визначала динаміку міжнародних резервів. Аналіз надходжень на валютні рахунки уряду в Національному банку та виплати Уряду України свідчить про те, що надходження від міжнародних партнерів були значно більшими, ніж обсяги інтервенцій НБУ з продажу валюти. У роботі наведене ранжування країн за загальним обсягом двосторонніх зобов’язань. Залученість кожної країни, що взяла зобов’язання з надання підтримки Україні було оцінено порівнюючи розміри допомоги представлені як частка до ВВП країни-донора.
ДЕТЕРМІНАНТИ КОНКУРЕНТОСПРОМОЖНОСТІ ТОРГОВОЇ МАРКИ ТОВ «ХОРОЛЬСЬКИЙ ЗАВОД ДИТЯЧИХ ПРОДУКТІВ ХАРЧУВАННЯ»
Authors: Кубишина Н. С. , Голобородько А. С.
Published: May 2024

У статті досліджено питання конкурентоспроможності торгової марки підприємства в умовах воєнного стану. Поглиблено теоретичні аспекти поняття «торгової марки». Систематизовані наукові підходи до визначення поняття «конкурентоспроможність підприємства», визначено значення торгової марки в контексті забезпечення конкурентоспроможності підприємства. Розглянуто основні переваги конкурентоспроможності торгової марки для зміцнення довіри споживачів. Запропоновано детермінанти конкурентоспроможності торгової марки як фізичне втілення обіцянок марки. Розроблено концепцію торгової марки в кризових умовах та в період війни. Запропоновано маркетингові заходи імплементації ключових детермінантів конкурентоспроможності торгової марки для діючого вітчизняного підприємства дитячого харчування.
ПЕРСПЕКТИВИ ВИКОРИСТАННЯ ТЕХНОЛОГІЙ 3D БІОДРУКУ ДЛЯ РЕГЕНЕРАТИВНОЇ ТЕРАПІЇ ПОШКОДЖЕНЬ ШКІРИ
Authors: Барановська Анастасія , Луценко Тетяна
Published: May 2024

До недавнього часу швидка регенерація тканин, заміна пошкоджених органів і відновлення їх функцій були мріями лікарів і пацієнтів. Поява тканинної інженерії та регенеративної медицини робить це можливим. Основними завданнями тканинної інженерії є поєднання клітин у поживні каркаси для створення компонентів для відновлення пошкоджених країв і тканин. Регенеративна медицина, у свою чергу, поєднує методи тканинної інженерії та різні стратегії, такі як генна терапія, імуномодуляція, тканинна терапія для здійснення функціонального відновлення, реконструкції тканин і органів. Дефіцит органів і тканин для трансплантації є глобальною проблемою [1]. Крім тривалого очікування донорських органів, результати трансплантації непередбачувані, оскільки велика частина операцій закінчується невдачею відразу або протягом 10 років після трансплантації, крім того, реципієнт змушений довічно приймати імунодепресанти, які підвищують ризик інфікування. Розвиток технологій автоматизації та створення нових біоматеріалів прискорив дослідження виробництва доклінічних моделей та біоштучних органів. 3D-друк є однією з таких автоматизованих технологій, яка отримала широкий розвиток протягом останніх десятків років і не втратила інтересу вчених завдяки своїй простоті та можливості створювати складні конструкції з використанням широкого спектру біоматеріалів. У сфері трансплантології існує потреба не тільки в розробці нових стратегій відновлення функціонування внутрішніх органів, а й у розробці методів отримання шкірних покривів, оскільки у світі мільйони людей страждають від хронічні шкірні захворювання або мають пошкодження шкіри внаслідок травм або опіків.
НАПРЯМКИ ЗАСТОСУВАННЯ БІОІМПЕДАНСОМЕТРІЇ В МЕДИЦИНІ
Authors: Худецький Ігор , Антонова-Рафі Юлія , Мельник Ганна , Римар Сергій
Published: May 2024

Постійне збільшення тривалості життя сприяє старінню населення та зростанню поширеності хронічних захворювань. Наслідком цього є вплив на соціально-економічну структуру суспільства з точки зору збільшення медичних витрат і потреб у сфері охорони здоров’я та соціального забезпечення. Ця проблема спонукала до нових технологічних досягнень (сенсорні пристрої, переносні системи, комунікаційні технології тощо) для покращення поточних систем охорони здоров’я та якості життя населення. Досліджуються та розробляються численні технології сенсоризації для їх застосування для моніторингу стану здоров’я, як у клінічному середовищі, так і в переносних пристроях для дистанційного моніторингу вдома користувачем: варіабельність серцевого ритму, рівень глюкози у крові, артеріальний тиск, температуру, фізичну активність тощо. Серед цих технологій провідне місце займає біоімпеданс, оскільки він дозволяє отримати уявлення про внутрішні процеси організму неінвазивним шляхом. Ця стаття має на меті провести ретельний огляд систем біоімпедансу для застосування в охороні здоров'я. Описано та проаналізовано такі застосування біоімпедансу, як оцінка складу тіла, імпедансна кардіографія, трансторакальна імпедансна пневмографія та електроімпедансна томографія. Також описано особливості застосування провідності шкіри для цілей біоімпедансометрії. Розглянуто проблему портативності систем для вимірювання біоімпедансу, необхідності взаємодії лікаря/медсестри з пацієнтом, питання оптимізації розміру апаратного забезпечення, надійності та точності, а також енергоспоживання, щоб максимізувати автономність пристроїв. Визначено необхідність покращення специфічності систем біоімпедансу, розробки стандартних протоколів калібрування, дослідження нових конфігурацій електродів і методів, щоб зменшити вплив анізотропних властивостей тканин.
Incentivos como instrumento para mejorar la productividad y eficiencia de una microempresa purificadora de agua
Authors: Carreón Romero Roberto Carlos , Ramírez Torres Alfredo
Published: May 2024

El presente trabajo surge de la necesidad de una microempresa purificadora de agua de Teziutlán, Puebla, México, de incrementar su productividad y hacer más eficiente su proceso de producción, ya que no cumple con la demanda de los clientes, así como de motivar a sus trabajadores a cumplir sus metas. Se aplicó y adaptó una metodología ya probada en otros estudios de caso donde se realiza producción en serie. Para lograr la meta de producción se realizó un análisis de proceso mediante un desglose de operaciones, así como un análisis de las operaciones de manufactura, por medio de un estudio de tiempos y movimientos con cronómetro, balanceo de línea y aplicación de tarifas diferenciales a los salarios. Al adaptar y aplicar la metodología se logró mejorar la productividad de 1.67 a 1.51 $/unidad (pesos mexicanos / garrafón de 19 litros lleno), la eficiencia pasó del 67.54 al 93.80 %, los trabajadores lograron un incremento salarial mínimo de 18.73 % y máximo de 31.93 % dependiendo de la estación de trabajo. Además, con la nueva organización para el trabajo se logró cubrir la demanda de los clientes.
Impacto del liderazgo transaccional en el rendimiento operativo
Authors: Mendoza Solís Maribel , García Alcaraz Jorge Luis
Published: May 2024

En este artículo se examina el impacto del liderazgo transaccional en el rendimiento operativo, teniendo como variable mediadora la satisfacción laboral en la industria manufacturera en Ciudad Juárez, Chihuahua, México. Se realizó una revisión de literatura sobre liderazgo transaccional, rendimiento operativo y satisfacción laboral para generar un cuestionario que fue aplicado a la industria maquiladora. Se obtuvieron 165 respuestas válidas al cuestionario, las cuales fueron analizadas mediante un modelo de ecuaciones estructurales basado en mínimos cuadrados parciales para validar tres hipótesis que relacionan las variables. El principal hallazgo que se encontró fue en la satisfacción laboral, donde se determina por el impacto que es la principal variable para obtener mayores niveles de rendimiento operativo, de forma independiente y mediadora, por lo cual la implicación práctica es implementar estrategias de desarrollo profesional y laboral dirigidas al trabajador para incrementar su satisfacción y así aumentar los beneficios sustanciales para la empresa.
Control pasivo de vibraciones para estructuras mecánicas amortiguadas bajo excitación armónica de aceleración en la base
Authors: Mendoza Larios José Gabriel , Barredo Hernández Eduardo , Maldonado Bravo Irving Abdiel , Mazón-Valadez Cuauhtémoc
Published: May 2024

Este trabajo se preocupa con la solución del problema de optimización H∞ para estructuras mecánicas amortiguadas de un grado de libertad (SDOF) acopladas al Absorbedor Dinámico de Vibraciones (DVA) clásico, bajo el efecto de movimientos armónicos del suelo. Con el objetivo de obtener primeramente fórmulas simples de diseño, se toma en cuenta la función de respuesta en frecuencia (FRF) de la estructura primaria no amortiguada como la función objetivo a ser minimizada en las frecuencias invariantes de control cuadradas. Para abordar esto, se aplica la técnica de los puntos fijos (FPT) basada en el enfoque de Krenk, y luego se producen soluciones cuasi-óptimas. Inspirado en la metodología de Nishihara, se calculó la medida de rendimiento de control H∞ resolviendo numéricamente un conjunto de ecuaciones no lineales, y tomando en cuenta las soluciones de forma cerrada producidas por la FPT como puntos de inicio para las iteraciones. Se observó que los puntos de resonancia de la estructura primaria amortiguada disminuyen cuando aumenta el amortiguamiento estructural. Independientemente del amortiguamiento estructural agregado al sistema mecánico, la metodología de optimización utilizada proporciona un buen compromiso para reducir con precisión los puntos de resonancia de la FRF.
Revolutionizing Early Education through Advanced Speaking Skills Approach
Authors: Ni’mah Alfa , Destiana Evie
Published: May 2024

This study implemented the show and tell method to enhance the speaking skills of 5-6-year-old children at Wonosari Muslimat Kindergarten. Using the Classroom Action Research (PTK) approach with collaborative planning, implementation, and reflection, data were collected through observation, interviews, and documentation. Results showed significant improvement, reaching 77.47% proficiency in the second cycle, meeting the 75% target. This research highlights the effectiveness of the show and tell method in improving early childhood speaking skills.
 
Highlight:

Show and Tell: Boosting Speaking Skills
Early Childhood Education: Language Development Focus
Action Research: Collaborative Improvement Approach

 

Keyword: Show and Tell Method, Speaking Skills, Early Childhood Education, Classroom Action Research, Improvement.
Using single cell sequencing to explore the difference in tumor- associated macrophages between left and right colon cancer and evaluate the prognosis of patient
Authors: Liao Kaili , Hu Yujie , Zhao Hanqing , Sun Bing , Fu Yuxin , Zhang Jingyan , Sun Xiaomeng , Xiong Zhenfang , Wang Xiaozhong
Published: May 2024

This research investigates the role of TAMs in left and right colon cancer progression, utilizing scRNA-seq to identify variances in TAMs and their microenvironment. We gathered macrophages from 12 left and 6 right colon cancer tissue samples, identifying 325 marker genes. Patients were stratified into three subgroups based on the expression of marker gene, which facilitated the examination of tumor microenvironment differences, immune cell infiltration, and immune checkpoint expression differences. WGCNA further identified 27 TAM characteristic genes. Two genes, CXCR4 and RGS2, were selected as prognostic genes through multivariate Cox regression analysis. Using these genes, we have created a TAM-related prognosis evaluation model, which was validated using external datasets. Our findings suggest that TAM-related genes have prognostic significance in colon cancer, offering potential therapeutic targets for left and right colon cancer treatment.
Wear mechanism of aggregated cBN grains during single-grain ultrasonic vibration-assisted grinding of γ-TiAl alloys
Authors: Song Jiahao , Zhao Biao , Ding Wenfeng , Zhao Yanjun , Zhu Jianhui , Cui Hailong
Published: May 2024

In this study, the wear mechanism of single aggregated cubic boron nitride (AcBN) grain during ultrasonic vibration-assisted grinding is investigated. The single AcBN grinding experiment are conducted under conventional grinding and ultrasonic vibration-assisted grinding on gamma titanium-aluminum intermetallic compounds, and the grain wear mechanism is comprehensively revealed by observing the radial wear height, normal force, average volume pile-up ratio, and morphology evolution of the grains with different maximum undeformed chip thicknesses, grinding speeds, and ultrasonic amplitudes. The experimental results show that the introduction of ultrasonic vibration produces periodic vibration of the workpiece in the tangential direction, which can produce intermittent dissociative behavior and effectively reduce normal force and average volume pile-up ratio of single AcBN grains when grinding, but also makes the instantaneous maximum undeformed chip thickness increase and introduces the periodic impact force, which accelerates the radial wear height of the AcBN grains. In addition, the ultrasonic vibration can effectively reduce the material adhesion in the AcBN grains surface and cause it to continuously undergo micro-fracture has better self-sharpening ability. In addition, excessive ultrasonic amplitude will lead to AcBN grains to occur macro-fracture and the expansion of bond cracks lead to abrasive grains pulling out, losing partial grinding ability.
Comparison of the Effect of Different Breastfeeding Education Methods on Breastfeeding Success
Authors: Yilmaz Melike Punduk , Oren Besey , Yilmaz Ismail , Cetin Ali
Published: May 2024

Background
Despite the well-documented benefits of breastfeeding, many first-time mothers encounter challenges. This study compares the efficacy of traditional face-to-face versus video-based breastfeeding education on improving breastfeeding practices and self-efficacy among primiparous mothers.
Methods
Using a sequential, quasi-experimental design, 70 primiparous mothers were enrolled from a State Hospital in Turkey and systematically divided into two groups: face-to-face education (n = 35) and video-based education (n = 35). The study spanned from January to June 2023, with participants evaluated using the Breastfeeding Self-Efficacy Scale-Short Form and the LATCH Breastfeeding Assessment Tool pre- and post-intervention.
Results
In the group that who received face-to-face breastfeeding education, the difference between pre-test and post-test score averages was statistically significant (p<0.05). While in the group that who received video-based breastfeeding education, the difference between pre-test and post-test score averages was not statistically significant (p<0.05).
Conclusion
It was concluded that face-to-face education is more effective in informing mothers compared to video-based education. However, video-based education also positively affected mothers breastfeeding, and there was no significant difference in breastfeeding skills between mothers who received video-based and face-to-face breastfeeding education.Further research is needed to explore the long-term impacts of these educational approaches on breastfeeding continuation rates.
Prevalence and risk factors for hypertension among children and adolescents in Shaanxi Province, Northwestern China, according to the three hypertension guidelines
Authors: Li Minmin , Wang Xinyan , Zhao Jingjun , Yang Nan , Wang Qianyun , Shi Wei , Bai Ruhai , Hui Tong
Published: May 2024

Thisstudy aimed to examine the prevalence and epidemiological characteristics of hypertension among children and adolescents aged 7-17 years in Shaanxi Province using three hypertension guidelines for children and adolescents. Data from the 2023 Shaanxi Student’s Health Surveillance Survey were used. Hypertension was defined according to three references, namely, the 2018 National Health Commission of the China (NHCC) pediatric blood pressure reference, the 2017 American Academy of Pediatrics (AAP) clinical practice guidelines, and the 2016 European Society of Hypertension guidelines. A log-binomial regression model was applied to assess the associations between hypertension and possible risk factors. A total of 220,497 students with an average age of 11.73 yearswere included in the analysis. The prevalence of hypertension was 11.73%, 15.75% and 10.04% according to the NHCC, APP and ESH guidelines,respectively. All three guidelines suggest that children who wereoverweight or obese or who lived in rural areas had significantly greater odds of having hypertension, and central and southern Shaanxi students had significantly lower odds of having hypertension. All three guidelines show that hypertension in children and adolescents seems to be a serious health problem in Shaanxi Province as well as in Northwestern China; thus, policymakers and public health practitioners should take immediate action to address the already established modifiable risk factors.
Dietary methionine supplementation improves cognitive dysfunction associated with transsulfuration pathway upregulation in mouse models of subacute aging
Authors: Yang Yuhui , Xu Yuncong , Shi Yonghui , Li Bowen , Xie Yanli , Le Guowei
Published: May 2024

Methionine (Met), an important substrate for protein synthesis and methyl donors, has also been shown to improve redox homeostasis in the body. However, its ability to ameliorate aging-induced cognitive dysfunction and the underlying mechanisms involved are still unknown. This study aimed to explore the effects of dietary Met supplementation on D-galactose-induced cognitive dysfunction and the associated mechanisms in mouse models of subacute aging. The mice were administrated 0.15 g/kg/day D-galactose subcutaneously and fed a normal (0.86% Met) or a Met-supplemented diet (1.72% Met) for 11 weeks. Various behavioral experiments were conducted, and we measured the plasma metabolite levels, hippocampal and plasma redox and inflammatory states, and hippocampal transsulfuration pathway-related parameters. We observed that dietary Met supplementation prevented aging-induced anxiety and cognitive deficiencies in subacute aging mice. Moreover, dietary Met supplementation normalized the plasma levels of multiple systemic metabolites involved in cognitive function as well as the redox and inflammatory states (e.g., betaine, taurine, and choline). Furthermore, dietary Met supplementation abolished oxidative stress and inflammation, selectively modulated the expression of multiple cognition-related genes, and increased flux via the transsulfuration pathway in the hippocampi of subacute aging mice, with significant increase in H2S and glutathione production. Our findings suggest that dietary Met supplementation prevented cognitive deficiencies in subacute aging mice, probably as a result of increased flux via the transsulfuration pathway.
Femoral Neck System versus Cannulated Compression Screws in the treatment of Unstable Femoral Neck Fractures：A retrospective study
Authors: Zong Xiangyu , Hu Yanling , Gong Haifeng , Zhang Chengdong , Huang Zhenchao , Zhao Qian , Zhang Yingze , Wang Tianrui
Published: May 2024

Objective
To compare the clinical effects of the Femoral neck system (FNS) and Cannulated compression screws (CCS) for the treatment of patients with unstable femoral neck fractures.
Methods
A retrospective analysis with pair matching of 98 patients who received FNS or CCS for unstable femoral neck fracture in our hospital from January 2019 to March 2023 was conducted. The patients who received FNS were in the test group, while those who received CCS were in the control group. General patient data and joint function were assessed using the Harris Hip Score (HHS) at 3, 6, and 12 months post-surgery. And surgical complications such as femoral head necrosis, nonunion, femoral neck shaft angle loss, and femoral neck shortening were recorded.
Results
There were no significant differences in age, sex, or the affected side between the two patient groups. Additionally, there were no statistically significant variances in surgery time, Garden Classification, and Garden alignment index. Analysis of the data revealed that more intraoperative bleeding in the FNS group than in the CCS group (\(85.45 \pm 51.24{\text{ mL vs}}.{\text{ }}63.02 \pm 32.4{\text{ mL}},{\text{ P}}<0.05\)). However, the FNS group have better postoperative Harris Score at 3, 6, and 12 months (\({\text{P}}<{\text{0}}{\text{.05}}\)), less postoperative femoral neck shortening at 6 and 12 months (\({\text{P}}<{\text{0}}{\text{.05}}\)), and fewer postoperative neck shaft angle losses at 6 and 12 months compared to the CCS group (\({\text{P}}<{\text{0}}{\text{.05}}\)). Furthermore, the incidence of femoral head necrosis was lower in the FNS group. The clinical efficacy and hip joint function of FNS internal fixation surgery for the treatment of unstable femoral neck fractures were superior to CCS internal fixation surgery during the follow-up period.
Conclusion
These findings indicate that FNS is a favorable internal fixation method for preserving the femoral head and achieving satisfactory clinical outcomes in patients with unstable femoral neck fractures. FNS internal fixation surgery is a better choice for the treatment of unstable femoral neck fractures.
Tuberculosis disease characteristics associated with mortality, severe morbidity and unsuccessful treatment in people living with HIV treated for tuberculosis – a secondary analysis of the ANRS 12300 Reflate TB2 trial
Authors: AKPATA Robert , N'Takpe Jean-Baptiste , MESSOU Eugène , DE CASTRO Nathalie , Chazallon Corine , Timana Isabel , Escada Rodrigo , Cardoso Sandra Wagner , Bhatt Nilesh , Khosa Celso , LAUREILLARD Didier , Chau Giang Do , Nogbou Frédéric Ello , Glao Donald Diomande , Veloso Valdiléa , Molina Jean-Michel , Grinsztejn Beatriz , Zannou Djimon Marcel , Eholie Serge , Marcy Olivier ,   ANRS 12300 Reflate TB2 study Consortium
Published: May 2024

Background
Tuberculosis is a severe disease, not only due to its lethality but also to a significant morbidity occurring in people living with HIV (PLWH). If factors associated to mortality, severe morbidity and unsuccessful treatment related to the host are well identified in PLWH, there is scarce knowledge on factors related to the disease itself such as bacillary load, extent of lung involvement and disease dissemination to other organs. We sought to assess whether tuberculosis-related factors were associated with key patient outcomes in PLWH using data from an international clinical trial.
Methods
We conducted a secondary analysis of the ANRS 12300 Reflate TB2 international phase III open-label randomized trial that assessed different antiretroviral regimens in PLWH treated for tuberculosis. We evaluated whether bacillary load (smear positivity grade), extent of lung involvement (cavitation on chest x-ray) and disease dissemination (urine LAM positivity) were associated with mortality using Cox proportional hazard models and to severe morbidity and unsuccessful tuberculosis treatment using logistic regressions.
Results
Of 457 participants included in this study, 90 (20.4%) had grade 2 + or 3 + smear positivity, 39 (10.8%) had cavitation on chest X-ray, and 147 (32.2%) had a positive urinary LAM. Overall, 19 (4.2%) participants died, 113 (24.7%) presented severe morbidity, and 33 (7.2%) had unsuccessful tuberculosis treatment. Factors that remained independently associated with mortality were cavitation on chest x-ray (aHR = 7.92, 95% CI, 1.74–35.94, p = .0073) and LAM positivity (aHR = 5.53, 95% CI, 1.09–28.06, p = .0389). The only factor that remained significantly associated with severe morbidity was LAM positivity (aOR = 2.04, 95% CI, 1.06–3.92, p = .0323). No factor remained significantly associated with unsuccessful tuberculosis treatment.
Conclusions
In PLWH with tuberculosis enrolled in a trial, tuberculosis disease characteristics related to disease severity were cavitation on chest x-ray and urine LAM positivity. Early identification of these factors could help improve the management of PLWH with tuberculosis and improve their survival.
Production of Alkaline protease from Bacillus amyloliquefaciens TAS-2 and Optimizing fermentation conditions
Authors: SHAH TAWAF ALI , Li Zhihe , Zhang Andong , Akhtar Hafiz Muhammad Saleem , Salamatullah Ahmad Mohammad Mohammad , Bourhia Mohammed
Published: May 2024

The aim of the present investigation was to standardize the conditions of batch fermentation for the production of a commercially significant alkaline protease from Bacillus amyloliquefaciens TAS-2. The B. amyloliquefaciens TAS-2 exhibited a distinct zone of clearance on the skim milk agar medium and demonstrated an enzyme activity of 38.6 U/mL after 24 hours of incubation at a pH of 7 and a temperature of 37°C. B. amyloliquefaciens TAS-2 was identified through genotypic analysis using 16S rRNA sequencing. The highest protease activity was obtained after 24 hours of incubation time, at pH 9, and temperature of 40°C. Similarly, maximum activity was observed with an agitation speed of 150 rpm, an inoculum age of 24 hours, an inoculum volume of 3% v/v, a substrate concentration of 3%, and a flask capacity of 250 mL. The activity was positively enhanced with addition of various nitrogen and carbon sources. Similarly, the presence of amino acids and metal ions induced protease production. However, the addition of Fe2 + and Zn2 + ions at specific concentrations in the medium was found to be inhibitory. Conversely, the addition of Mg2 + and Ca2 + ions had a stimulating effect on protease production. All the optimized parameters were incorporated into the basal medium, and fermentation was conducted under optimal conditions. The precipitation of the maximum amount of protein was achieved at 70–80% saturation of ammonium sulfate. The protease activity was 1.56 time higher for the partially purified protease compared to the crude supernatant. The partially purified protease exhibited optimum activity at a temperature of 55°C and a pH of 9. At 5 mM, PMSF significantly suppressed enzyme activity, whereas Triton X-100 and CTAB increased enzyme activity. Among the different metal ions tested, Ca2+ (5 mM), Mg2+ (5 mM), and Mn2+ (5 mM) stimulated enzyme activity, while Zn2 + and Fe2 + decreased protease activity. The enzyme demonstrated remarkable stability, retaining its activity even after being heated to 60°C for 60 minutes and remaining stable within a pH range of 8 to 11. The study suggests that the alkaline protease of B. amyloliquefaciens TAS-2 that is thermotolerant and surfactant stable can have potential applications across different industries due to its ability to improve yield and properties.
Prevalence and influence factor of drug-related problems in inpatients with kidney disease: A prospective single central study
Authors: Guo-guang Gu , Yan-ping Li , Yun-yun Hu , Heng-yi Zhao , Xing-dong Wang , Xiao-min Li , Xin-ran Zhang , Hong Zhu , Xiao-hua Dai , Xing-xing Liu , Li-yan Miao , jian-guo Zhu , Yong-fu Hang
Published: May 2024

Aims: To investigate the prevalence and influencing factors of drug-related problems (DRPs) in inpatients with kidney disease to provide a reference data forpharmaceutical care.
Methods: The basic information, diagnoses, and medicationreconciliation (MR) of inpatients in the Department of Nephrology at our hospital between October 2020 and September 2021 were collected. The Chinese-modified DRP version based on the PCNE classification (Version 9.1) was used to assess, intervene and statistically analyze the results of the patients’ DRPs .
Results: Out of 623 patients included in this study, 132 (21.80%) were found to have DRPs. The prevalence of anemia was significantly higher in patients with DRPs than those without DRPs (43.18% vs. 28.72%, P < 0.05), the mean number of drug types consumed (7.25 ± 3.44 vs. 5.93 ± 3.58, P < 0.05) and the proportion of ≥ 5 drugs (%) (79.55% vs. 58.04%, P < 0.05) were significantly increased. In addition, the incidence of hypertension (76.52% vs 68.64%), diabetes (27.27% vs 22.20%) and hyperuricemia (16.67% vs 13.65%) in DRPs patients were higher than those without DRPs, but there was no statistical difference (P>0.05). The distribution of harm levels was as follows: 78 problems (59.09%) were level C, 29 (21.97%) were level B, 10 (7.58%) were level D, 7（5.30%）were level A, 7(5.30%) were level E, and 1(0.76%) were level F. All DRPs were resolved after 128 interventions.
Conclusion: Renal anemia, the average number of drug varieties consumed, and the proportion of ≥ 5 drugs are associated with the occurrence of DRPs. Pharmacists conducting MR services can reduce DRPs of inpatients in the department of nephrology and ensure patient's drug safety.