bluuebunny/crossref_metadata_2025 huggingface dataset:
Effects of Lycium barbarum Polysaccharides on Immunity and Metabolic Syndrome Associated with the Modulation of Gut Microbiota: A Review
Authors: Cao Cui , Wang Zhongfu , Gong Guiping , Huang Wenqi , Huang Linjuan , Song Shuang , Zhu Beiwei
Published: October 2022

Lycium barbarum polysaccharides (LBPs) have attracted increasing attention due to their multiple pharmacological activities and physiological functions. Recently, both in vitro and in vivo studies have demonstrated that the biological effects of dietary LBPs are related to the regulation of gut microbiota. Supplementation with LBPs could modulate the composition of microbial communities, and simultaneously influence the levels of active metabolites, thus exerting their beneficial effects on host health. Interestingly, LBPs with diverse chemical structures may enrich or reduce certain specific intestinal microbes. The present review summarizes the extraction, purification, and structural types of LBPs and the regulation effects of LBPs on the gut microbiome and their derived metabolites. Furthermore, the health promoting effects of LBPs on host bidirectional immunity (e.g., immune enhancement and immune inflammation suppression) and metabolic syndrome (e.g., obesity, type 2 diabetes, and nonalcoholic fatty liver disease) by targeting gut microbiota are also discussed based on their structural types. The contents presented in this review might help to better understand the health benefits of LBPs targeting gut microbiota and provide a scientific basis to further clarify the structure–function relationship of LBPs.
Knowledge, Attitudes and Practices of the Lebanese Community toward Food Adulteration
Authors: Khanafer May , El Harake Marwa Diab , Toufeili Imad , Kharroubi Samer A.
Published: October 2022

Food adulteration is the purposeful act of decreasing the quality of food goods offered for sale, whether by adding or replacing inferior substances or by the removal of some valuable ingredient. A limited number of studies have explored the knowledge, attitudes and practices (KAPs) concerning food adulteration in Lebanon. The objectives of the present study were to determine the knowledge, attitudes and practices of identifying adulteration in the process of food purchase by Lebanese adult consumers, and to identify factors associated with food adulteration. An online survey (n = 499) was administered among Lebanese adults aged 18 years and above. Results showed that the majority had a low food adulteration knowledge score (73.1%). During shopping, fewer than half of the participants checked the ingredients (42%) and nutrition facts label (33.9%). Regression analyses showed that six predictors were significantly associated with participants’ knowledge scores including gender, age, marital status, education (undergraduate and master degree) and employment status (student). The results of this study show that knowledge and practices of identifying adulteration in the process of food purchase by consumers are lacking among most respondents. Increasing knowledge, awareness and motivation to identify food adulteration products during food shopping will empower consumers to improve buying practices, especially for the public with a lower level of education.
Potential Correlation between Microbial Diversity and Volatile Flavor Compounds in Different Types of Korean Dry-Fermented Sausages
Authors: Kim Jong-Hui , Lee Eun-Seon , Kim Bu-Min , Oh Mi-Hwa
Published: October 2022

The microbial community in fermented sausages plays an important role in determining their quality characteristics. The objective of this study was to investigate the correlation between microbial diversity and volatile compounds in dry-fermented sausages procured from different regions of Korea. Results from metagenomics analysis showed that Lactobacillus and Staphylococcus were the predominant bacterial genera, and Penicillium, Debaryomyces, and Candida were the predominant fungal genera. Twelve volatile compounds were detected using an electronic nose. Leuconostoc exhibited a positive correlation with esters and volatile flavor, whereas Debaryomyces, Aspergillus, Mucor, and Rhodotorula exhibited a negative correlation with methanethiol, thus revealing the involvement of the microorganisms in flavor formation. The results of this study may help in understanding the microbial diversity of dry-fermented sausages in Korea and provide a rationale and quality control guideline through potential correlation with volatile flavor analysis.
Optimization of Extraction Process, Structure Characterization, and Antioxidant Activity of Polysaccharides from Different Parts of Camellia oleifera Abel
Authors: Feng Shiling , Tang Min , Jiang Zhengfeng , Ruan Yunjie , Liu Li , Kong Qingbo , Xiang Zhuoya , Chen Tao , Zhou Lijun , Yang Hongyu , Yuan Ming , Ding Chunbang
Published: October 2022

The flowers, leaves, seed cakes and fruit shells of Camellia oleifera are rich in bioactive polysaccharides, which can be used as additives in food and other industries. In this study, a Box−Behnken design was used to optimize the extraction conditions of polysaccharides from C. oleifera flowers (P-CF), leaves (P-CL), seed cakes (P-CC), and fruit shells (P-CS). Under the optimized extraction conditions, the polysaccharide yields of the four polysaccharides were 9.32% ± 0.11 (P-CF), 7.57% ± 0.11 (P-CL), 8.69% ± 0.16 (P-CC), and 7.25% ± 0.07 (P-CS), respectively. Polysaccharides were mainly composed of mannose, rhamnose, galacturonic acid, glucose, galactose, and xylose, of which the molecular weights ranged from 3.31 kDa to 128.06 kDa. P-CC had a triple helix structure. The antioxidant activities of the four polysaccharides were determined by Fe2+ chelating and free radical scavenging abilities. The results showed that all polysaccharides had antioxidant effects. Among them, P-CF had the strongest antioxidant activity, of which the highest scavenging ability of DPPH•, ABTS•+, and hydroxyl radical could reach 84.19% ± 2.65, 94.8% ± 0.22, and 79.97% ± 3.04, respectively, and the best chelating ability of Fe2+ could reach 44.67% ± 1.04. Overall, polysaccharides extracted from different parts of C. oleifera showed a certain antioxidant effect, and could be developed as a new type of pure natural antioxidant for food.
Fabrication and Evaluation of Graphene Oxide/Hydroxypropyl Cellulose/Chitosan Hybrid Aerogel for 5-Fluorouracil Release
Authors: Sang Yanan , Miao Pengpai , Chen Tao , Zhao Yuan , Chen Linfeng , Tian Yayang , Han Xiaobing , Gao Jie
Published: October 2022

The incorporation of graphene oxide (GO) into a polymeric drug carrier can not only enhance the loading efficiency but also reduce the initial burst and consequently improve the controllability of drug release. Firstly, 5-fluorouracil (5-Fu)-loaded hydroxypropyl cellulose/chitosan (HPC/CS@5-Fu) and GO/HPC/CS@5-Fu aerogels were successfully fabricated through chemical cross-linking with glutaraldehyde. Then, the obtained aerogels were characterized using scanning electron microscopy (SEM), Fourier transform infrared (FITR), X-ray diffraction (XRD), differential scanning calorimetry (DSC), thermogravimetry (TG), and the effect of HPC and GO content on the drug loading (DL) and encapsulation efficiency (EE) for the two aerogels were investigated, respectively. Finally, the drug release behavior of the GO/HPC/CS@5-Fu aerogels with different GO content was evaluated at two different pH values, and four kinds of kinetic models were used to evaluate the release behavior.
FBN1 Splice-Altering Mutations in Marfan Syndrome: A Case Report and Literature Review
Authors: Wang James Jiqi , Yu Bo , Sun Yang , Song Xiuli , Wang Dao Wen , Li Zongzhe
Published: October 2022

Marfan syndrome (MFS) is a life-threatening autosomal dominant genetic disorder of connective tissue caused by the pathogenic mutation of FBN1. Whole exome sequencing and Sanger sequencing were performed to identify the pathogenic mutation. The transcriptional consequence of the splice-altering mutation was analyzed via minigene assays and reverse-transcription PCR. We identified a novel pathogenic mutation (c.8051+1G>C) in the splice site of exon 64 of the FBN1 gene in an MFS-pedigree. This mutation was confirmed to cause two different truncated transcripts (entire exon 64 skipping; partial exon 64 exclusion). We also systematically summarized previously reported transcriptional studies of pathogenic splice-altering mutations in the FBN1 gene to investigate the clinical and transcriptional consequences. In conclusion, we reported for the first time that a splice-altering mutation in the FBN1 gene leads to two abnormal transcripts simultaneously.
Evaluating Measurement Properties of the Adapted Interprofessional Collaboration Scale through Rasch Analysis
Authors: Wieser Heike , Mischo-Kelling Maria , Cavada Luisa , Lochner Lukas , Fink Verena , Naletto Carla , Vittadello Fabio
Published: October 2022

This study aimed to evaluate the validity and reliability of the German and Italian versions of the Interprofessional Collaboration Scale (IPC scale) by applying a Rasch analysis. Data were gathered from 1182 nurses participating in a cross-sectional study in northern Italy. The scale demonstrated good reliability (Cronbach’s alpha = 0.92). Item polarity of all 13 items was positive, indicating good construct validity. However, revising one item would further improve the validity of the scale. Item stability was confirmed for work experience, workplace, age range, the language version, and gender. The analysis, applying a non-classical test theory, confirmed that the IPC scale is a valid and reliable instrument to measure interprofessional collaboration between nurses and physicians.
Prism Adaptation Treatment Predicts Improved Rehabilitation Responses in Stroke Patients with Spatial Neglect
Authors: Vilimovsky Tomas , Chen Peii , Hoidekrova Kristyna , Slavicek Ondrej , Harsa Pavel
Published: October 2022

Spatial neglect (SN) impedes functional recovery after stroke, leading to reduced rehabilitation gains and slowed recovery. The objective of the present study was to investigate whether integrating prism adaptation treatment (PAT) into a highly intensive rehabilitation program eliminates the negative impact of spatial neglect on functional and motor recovery. We examined clinical data of the 355 consecutive first-time stroke patients admitted to a sub-acute inpatient neurorehabilitation program that integrated PAT. The 7-item Motor Functional Independence Measure, Berg Balance Scale, and Motor Activity Log were used as main outcome measures. We found that 84 patients (23.7%) had SN, as defined by a positive score on the Catherine Bergego Scale via the Kessler Foundation Neglect Assessment Process (KF-NAP®). Although 71 patients (85%) received PAT, the presence of SN at baseline, regardless of PAT completion, was associated with lower functional independence, higher risk of falls, and a lower functional level of the affected upper limb both at admission and at discharge. The severity of SN was associated with inferior rehabilitation outcomes. Nonetheless, patients with SN who received PAT had similar rehabilitation gains compared to patients without SN. Thus, the present study suggests that integrating PAT in an intensive rehabilitation program will result in improved responses to regular therapies in patients with SN.
A Discussion of Whether Various Lifestyle Changes can Alleviate the Symptoms of Irritable Bowel Syndrome
Authors: Okawa Yohei
Published: October 2022

Irritable bowel syndrome (IBS) causes abdominal pain during bowel movements and is diagnosed according to the Rome IV international diagnostic criteria. Patients diagnosed as having IBS experience abdominal pain at least 1 day/week, on average, over a 3-month period and not 3 days per month. A diagnosis of IBS is confirmed if symptoms have persisted for more than 6 months. IBS symptoms negatively affect daily life. First, improving daily habits are important to ameliorating IBS symptoms. IBS symptoms can be alleviated by staying active, sleeping, resting and staying stress-free. In addition, it is important to eat three, balanced meals a day on a regular basis and avoid overeating, especially at night. Spicy foods, high-fat foods, and alcohol can exacerbate symptoms. Researchers found, in a literature review, that IBS symptoms can be ameliorated by improving daily habits, thus relieving abdominal pain and the defecation symptoms of IBS.
Protocols of Investigation of Neonatal Cholestasis—A Critical Appraisal
Authors: Quelhas Patricia , Jacinto Joana , Cerski Carlos , Oliveira Rui , Oliveira Jorge , Carvalho Elisa , dos Santos Jorge
Published: October 2022

Neonatal cholestasis (NC) starts during the first three months of life and comprises extrahepatic and intrahepatic groups of diseases, some of which have high morbimortality rates if not timely identified and treated. Prolonged jaundice, clay-colored or acholic stools, and choluria in an infant indicate the urgent need to investigate the presence of NC, and thenceforth the differential diagnosis of extra- and intrahepatic causes of NC. The differential diagnosis of NC is a laborious process demanding the accurate exclusion of a wide range of diseases, through the skillful use and interpretation of several diagnostic tests. A wise integration of clinical-laboratory, histopathological, molecular, and genetic evaluations is imperative, employing extensive knowledge about each evaluated disease as well as the pitfalls of each diagnostic test. Here, we review the difficulties involved in correctly diagnosing the cause of cholestasis in an affected infant.
Poultry Concentrated Animal-Feeding Operations on the Eastern Shore, Virginia, and Geospatial Associations with Adverse Birth Outcomes
Authors: Mendrinos Antonia , Ramesh Balaji , Ruktanonchai Corrine W. , Gohlke Julia M.
Published: October 2022

Concentrated animal-feeding operations (CAFOs) emit pollution into surrounding areas, and previous research has found associations with poor health outcomes. The objective of this study was to investigate if home proximity to poultry CAFOs during pregnancy is associated with adverse birth outcomes, including preterm birth (PTB) and low birth weight (LBW). This study includes births occurring on the Eastern Shore, Virginia, from 2002 to 2015 (N = 5768). A buffer model considering CAFOs within 1 km, 2 km, and 5 km of the maternal residence and an inverse distance weighted (IDW) approach were used to estimate proximity to CAFOs. Associations between proximity to poultry CAFOs and adverse birth outcomes were determined by using regression models, adjusting for available covariates. We found a −52.8 g (−95.8, −9.8) change in birthweight and a −1.51 (−2.78, −0.25) change in gestational days for the highest tertile of inverse distance to CAFOs. Infants born with a maternal residence with at least one CAFO within a 5 km buffer weighed −47 g (−94.1, −1.7) less than infants with no CAFOs within a 5 km buffer of the maternal address. More specific measures of exposure pathways via air and water should be used in future studies to refine mediators of the association found in the present study.
Deep Learning in Historical Architecture Remote Sensing: Automated Historical Courtyard House Recognition in Yazd, Iran
Authors: Yazdi Hadi , Sad Berenji Shina , Ludwig Ferdinand , Moazen Sajad
Published: October 2022

This research paper reports the process and results of a project to automatically classify historical and non-historical buildings using airborne and satellite imagery. The case study area is the center of Yazd, the most important historical site in Iran. New computational scientific methods and accessibility to satellite images have created more opportunities to work on automated historical architecture feature recognition. Building on this, a convolutional neural network (CNN) is the main method for the classification task of the project. The most distinctive features of the historical houses in Iran are central courtyards. Based on this characteristic, the objective of the research is recognizing and labeling the houses as historical buildings by a CNN model. As a result, the trained model is tested by a validation dataset and has an accuracy rate of around 98%. In Sum, the reported project is one of the first works on deep learning methods in historical Iranian architecture study and one of the first efforts to use automated remote sensing techniques for recognizing historical courtyard houses in aerial images.
Virtual Sea-Drifting Experiments between the Island of Cyprus and the Surrounding Mainland in the Early Prehistoric Eastern Mediterranean
Authors: Kyriakidis Phaedon , Moutsiou Theodora , Nikolaidis Andreas , Reepmeyer Christian , Leventis Georgios , Demesticha Stella , Akylas Evangelos , Kassianidou Vasiliki , Michailides Constantine , Zomeni Zomenia , Bar-Yosef Mayer Daniella E. , Makovsky Yizhaq , McCartney Carole
Published: October 2022

Seaborne movement underpins frontier research in prehistoric archaeology, including water-crossings in the context of human dispersals, and island colonisation. Yet, it also controls the degree of interaction between locations, which in turn is essential for investigating the properties of maritime networks. The onset of the Holocene (circa 12,000 years ago) is a critical period for understanding the origins of early visitors/inhabitants to the island of Cyprus in the Eastern Mediterranean in connection with the spread of Neolithic cultures in the region. The research undertaken in this work exemplifies the synergies between archaeology, physical sciences and geomatics, towards providing novel insights on the feasibility of drift-induced seaborne movement and the corresponding trip duration between Cyprus and coastal regions on the surrounding mainland. The overarching objective is to support archaeological inquiry regarding the possible origins of these visitors/inhabitants—Anatolia and/or the Levant being two suggested origins.
Seeing with the Strong Programme
Authors: Kehoe Alice B.
Published: October 2022

Using the Strong Programme developed in Edinburgh in the 1970s clarifies how to do sociology of science freed from Enlightenment paradigms of testing for Truth. This paper uses, as an example, the case of Lewis Binford and his wife (in the 1960s) Sally Rosen, revealing Rosen’s work to make Lewis’s writing clear and persuasive. Rosen’s work was the efficient cause of Lewis Binford’s success with the New Archaeology.
Coping and Resilience Strategies among Ukraine War Refugees
Authors: Oviedo Lluis , Seryczyńska Berenika , Torralba Josefa , Roszak Piotr , Del Angel Javier , Vyshynska Olena , Muzychuk Iryna , Churpita Slava
Published: October 2022

(1) Background: The war in Ukraine has triggered a huge humanitarian crisis: millions of refugees have escaped from their homes looking for shelter beyond Ukraine’s borders. This emergency offers a unique opportunity to investigate and to document those characteristics of the human condition that emerge in exceptional circumstances provoked by war. Based on considerations derived from recent studies on resilience, the research at the base of this paper was conducted to better understand the circumstances, states of mind, and coping mechanisms of the refugees leaving their homes looking for security. (2) Methods: A qualitative approach was applied, resorting to semi-structured interviews (n = 94) to closely explore the traumatic experiences lived by refugees and to identify their coping strategies. (3) Results: The data obtained pointed to a plurality of coping and resilience strategies. Maintaining communication with separated loved ones as well as experiencing accompaniment by helpers and hosts emerged as principal elements for coping and resilience. It was found that a prior development of interior life or practice of prayer served as psychological “capital” that increased their resilience. (4) Conclusion: The results point to the need to care for social networking, attention by hosts, and cultivating interior life as keys for resilience.
Cirques of the Southeastern Tibetan Plateau and Their Links to Climatic and Non-Climatic Factors
Authors: Li Shengxian , Zhang Qian , Wang Jiahan
Published: October 2022

Cirque morphology is used to reflect the patterns of paleoclimate, paleoglaciation, and landscape evolution. Cirque study has been conducted in the Gangdise Mountains of the southern Tibetan Plateau (TP) and the central TP (dominated by a weak Indian summer monsoon (ISM) or a continental climate). This study focused on the cirques in the southeastern TP, which is dominated by a strong ISM, to analyse the controlling factors on cirque morphology. A total of 361 cirques were mapped in the Taniantaweng Range of the southeastern TP, and their metrics were calculated. The results showed that the cirque sizes increased with temperature and decreased with precipitation, which may be due to the development of valley-type glaciers and the effect of non-climatic factors. The cirques tended to face NE, implying that they prefer leeward slopes, and they were under the ‘morning–afternoon’ effect. With altitude, the tendency of the cirque aspect shifted from N to SE, and the cirque size decreased. The former may indicate the ability of the high altitude to support cirque development on climatically unfavourable slopes; the latter may be due to the development of valley-type glaciers or insufficient space for cirque development. The cirque size and shape did not show statistical differences between aspects. The cirques on soft bedrocks had larger heights than those on hard bedrocks, indicating that soft bedrocks promote subglacial erosion. A comparison with the results of the western, central, and eastern sectors of the Gangdise Mountains and the central TP reveals that the strength of the ISM did not necessarily increase the cirque density but limited the cirque size on a regional scale. The CFA did not show a reverse relationship with precipitation, but it showed a positive correlation with the cirque Zmean, which implies that the CFA was greatly affected by altitude, and its distribution does not always reflect paleoclimatic patterns.
Tourism as a Tool in Nature-Based Mental Health: Progress and Prospects Post-Pandemic
Authors: Buckley Ralf C. , Cooper Mary-Ann
Published: October 2022

The healthcare sector recognises the role of nature in mental health. The tourism sector is equipped to take people to national parks. The conservation sector gains support from visitors. Theoretical frameworks for mental health benefits from nature tourism include: tourism destinations and activities; tourist personalities and life histories; sensory and emotional components of tourist experiences; and intensity and duration of memories. Mental health deteriorated worldwide during the COVID-19 pandemic. Recovery of global economic productivity requires immediate, accessible, affordable mental health measures at national scales, and nature-based approaches provide the best option. Different countries have adopted a variety of public, private, or voluntary mechanisms. Some focus on design of activities, others on provision of facilities. Costs and implementation depend on key research questions: marginal benefits of nature tour guides or psychologists compared to self-guided nature experiences; comparisons between repeated brief visits and one-off nature holidays; effects of biodiversity, flagship species, and scenic or wilderness quality; and differences between individuals, depending on personalities, life histories, and mental health status and symptoms.
Factors Associated with Pro-Environmental Behaviors in Israel: A Comparison between Participants with and without a Chronic Disease
Authors: Shinan-Altman Shiri , Hamama-Raz Yaira
Published: October 2022

This study examined differences regarding climate change pro-environmental behaviors (PEBs), comparing between individuals with chronic diseases and those without. A cross-sectional survey was conducted among 402 adults, of whom 25% had a chronic disease. Participants completed measures for PEBs, climate change exposure (i.e., exposure to its effects), climate change risk appraisal, environmental self-efficacy, collective efficacy, and sociodemographic variables. Results revealed a significant difference between participants with and without chronic diseases in climate change risk appraisal. Having a chronic disease was associated with higher climate change risk appraisal (β = 0.16, p < 0.001), which in turn was associated with higher collective efficacy (β = 0.29, p < 0.001). The latter was associated with more PEBs (β = 0.10, p = 0.049). Furthermore, higher climate change exposure was associated with higher climate change risk appraisal (β = 0.49, p < 0.001), which in turn was associated with collective efficacy (β = 0.29, p < 0.001). The latter was associated with more PEBs (β = 0.10, p = 0.049). In addition, higher climate change exposure was directly associated with both self-efficacy (β = 0.33, p < 0.001) and collective efficacy (β = 0.10, p = 0.049), which in turn were associated with more PEBs (β = 0.28, p < 0.001 and β = 0.10, p = 0.049, respectively). This study highlights the need to provide efficacy-enhancing information in climate change messaging for PEBs in general. A threat component in environment-relevant messages for people with chronic diseases, specifically, should also be adopted.
The ABC-X’s of Stress among U.S. Emerging Adults during the COVID-19 Pandemic: Relationship Quality, Financial Distress, and Mental Health
Authors: LeBaron-Black Ashley B. , Yorgason Jeremy B. , Curran Melissa A. , Saxey Matthew T. , Okamoto Rachel M.
Published: October 2022

Many emerging adults have experienced increased financial distress and mental health problems during the COVID-19 pandemic, and isolation may have amplified the importance of close relationships (especially as parents’ influence diminishes during this developmental stage). Using the ABC-X Model to frame our model, we tested whether financial distress (C) mediates the associations between COVID-19 impact (A) and anxiety and depressive symptoms (X), and whether or not romantic relationship quality (B) moderates these indirect associations. Our sample comprised of 1950 U.S. emerging adults in a romantic relationship. Mediation and first-stage moderated mediation were tested using structural equation modeling. Financial distress partially mediated the association between COVID-19 impact and anxiety symptoms and fully mediated the association between COVID-19 impact and depressive symptoms. Strong evidence of moderated mediation was found but in the opposite direction expected: the indirect associations of COVID-19 impact with anxiety and depressive symptoms (through financial distress) were stronger for those in high-quality romantic relationships. The findings may inform policy and practice aimed at optimizing the mental health of emerging adults, especially in light of the ongoing COVID-19 pandemic: specifically, alleviating financial distress may improve the mental health of emerging adults, while focusing on the quality of their romantic relationships may not.
Is This All COVID-19′s Fault? A Study on Trainees in One of the Most Affected Italian Cities
Authors: Manfredi Paola
Published: October 2022

Many studies have investigated the state of the health of healthcare workers during the acute period of the pandemic. Yet, few studies have assessed the health of such professionals after the pandemic and in a less dramatic period. This study involved a particular sample represented by residents in anaesthesia–resuscitation and psychiatry at a university in northern Italy particularly affected by the pandemic. The objectives were to investigate some indicators of health and well-being and compare the two groups of trainees. Using Google Forms, the following tests were proposed: the General Health Questionnaire, Maslach Burnout Inventory, Subjective Happiness Scale, Satisfaction with Life Scale, Coping Inventory for Stressful Situations, Brief Resilience Scale, State-Trait Anxiety Inventory, as well as an ad hoc questionnaire. A qualifying element of the work was the discussion of the results with the trainees. Various strengths have emerged, such as high values of resilience and job satisfaction; a positive assessment of the support received from the work team; an articulate use of coping strategies; and good levels of happiness and satisfaction with life, in both specialities. However, a widespread anxiety also emerged, which appears to be more attributable to concerns about professional evaluation, rather than the pandemic itself. In summary, the trainees seem to have found a fair amount of personal balance, whereas the relationship with the patient seems to be more compromised. In the comparison between specialities, the only significant differences are the levels of depersonalisation and resilience, both of which are higher in anaesthetists.
Prevalence and Patterns of Prenatal Alcohol Exposure in Australian Cohort and Cross-Sectional Studies: A Systematic Review of Data Collection Approaches
Authors: Young Sophia L. , Steane Sarah E. , Kent Nykola L. , Reid Natasha , Gallo Linda A. , Moritz Karen M.
Published: October 2022

This study sought to determine data collection approaches in Australian cohort studies and explore the potential impact on reported prenatal alcohol exposure (PAE) prevalence and patterns. Inclusion criteria were that studies related to a general Australian antenatal population where PAE was assessed and reported. Studies were excluded if they were not peer reviewed, examined the prevalence of PAE in pregnancies complicated by alcohol-use disorders, or were published in a language other than English. A systematic search of five electronic databases (PubMed, Embase, CINAHL, Web of Science, and Scopus) was conducted. Risk of bias was assessed using the Effective Public Health Practice Project quality assessment tool. Results were synthesised using MetaXL. Data from 16 separate birth cohorts (n = 78 articles) were included. Included cohorts were either general cohorts that included alcohol as a variable or alcohol-focused cohorts that were designed with a primary focus on PAE. PAE prevalence was estimated as 48% (95% CI: 38 to 57%). When subgroup analysis was performed, estimates of PAE prevalence when self-administered surveys and interviews were used for data collection were 53% (95% CI: 41% to 64%) and 43% (95% CI: 28% to 59%), respectively. Use of trained assessors was an influencing factor of the prevalence estimates when data were collected via interview. Alcohol-focused studies reported higher prevalence of PAE, regardless of method of survey administration. Where interviewer training is not possible, self-administered questionnaires will likely provide the most reliable PAE estimates. No funding sources are relevant to mention. Review was registered with PROSPERO (CRD42020204853).
Influence of Efficient Thickness of Antireflection Coating Layer of HfO2 for Crystalline Silicon Solar Cell
Authors: Shah Deb Kumar , KC Devendra , Umar Ahmad , Algadi Hassan , Akhtar Mohammad Shaheer , Yang O-Bong
Published: October 2022

Anti-reflective coating (ARC) layers on silicon (Si) solar cells usually play a vital role in the amount of light absorbed into the cell and protect the device from environmental degradation. This paper reports on the thickness optimization of hafnium oxide (HfO2) as an ARC layer for high-performance Si solar cells with PC1D simulation analysis. The deposition of the HfO2 ARC layer on Si cells was carried out with a low-cost sol-gel process followed by spin coating. The thickness of the ARC layer was controlled by varying the spinning speed. The HfO2 ARC with a thickness of 70 nm possessed the lowest average reflectance of 6.33% by covering wavelengths ranging from 400–1000 nm. The different thicknesses of HfO2 ARC layers were used as input parameters in a simulation study to explore the photovoltaic characteristics of Si solar cells. The simulation findings showed that, at 70 nm thickness, Si solar cells had an exceptional external quantum efficiency (EQE) of 98% and a maximum power conversion efficiency (PCE) of 21.15%. The thicknesses of HfO2 ARC considerably impacted the photovoltaic (PV) characteristics of Si solar cells, leading to achieving high-performance solar cells.
Small Islands, Small Ponds, Small Communities—Water Beetles and Water Boatmen in the Faroe Islands
Authors: Hansen Leivur Janus , Kreiling Agnes-Katharina
Published: October 2022

Water beetles of the families Dytiscidae and Haliplidae (Coleoptera) as well as water boatmen (Heteroptera: Corixidae) are well-studied groups in Northern Europe. In the Faroe Islands, their diversity is much lower than in the British Isles and Fennoscandia. Here, we first describe the communities of water beetles and water boatmen in Faroese ponds and, secondly, assess whether community compositions are driven by habitat characteristics or dispersal abilities of species. To this end, we sampled 57 ponds, ranging between <50 m2 and >50,000 m2. Environmental variables such as pond size, temperature, pH, and depth were measured, and distance to nearest neighboring pond was calculated as a measure of isolation. The sampling yielded 1522 individuals of eight species, with species richness of the ponds ranging between zero and six. Pond size (shoreline length) did explain differences in community composition, whereas water depth explained differences in diversity indices with lower diversity in deeper ponds. We found species-specific relations between abundance and shoreline length, e.g., H. fulvus and H. palustris being restricted to larger ponds. Lastly, water beetle and water boatmen communities in Faroese ponds are discussed in the light of island biogeography and species distributions in the North Atlantic islands.
First Detection of Honeybee Pathogenic Viruses in Butterflies
Authors: Pislak Ocepek Metka , Glavan Gordana , Verovnik Rudi , Šimenc Laura , Toplak Ivan
Published: October 2022

Several pathogens are important causes of the observed pollinator decline, some of which could be transmitted between different pollinator species. To determine whether honeybee viruses can be transmitted to butterflies, a total of 120 butterflies were sampled at four locations in Slovenia. At each location, butterflies from three families (Pieridae, Nymphalidae, Hesperiidae/Lycenidae) and Carniolan honeybees (Apis mellifera carnica) were collected. The RNA of six honeybee viruses, i.e., acute bee paralysis virus (ABPV), black queen cell virus (BQCV), chronic bee paralysis virus (CBPV), deformed wing virus A (DWV-A), Sacbrood bee virus (SBV), and Lake Sinai virus 3 (LSV3), was detected by a specific quantitative method (RT-PCR). The presence of ABPV, BQCV, LSV3, and SBV was detected in both butterflies and honeybees. All butterfly and bee samples were negative for CBPV, while DWV-A was detected only in honeybees. The viral load in the positive butterfly samples was much lower than in the positive bee samples, which could indicate that butterflies are passive carriers of bee viruses. The percentage of positive butterfly samples was higher when the butterflies were collected at sampling sites with a higher density of apiaries. Therefore, we believe that infected bees are a necessary condition for the presence of viruses in cohabiting butterflies. This is the first study on the presence of pathogenic bee viruses in butterflies.
The Effect of Body Fat Distribution on Systemic Sclerosis
Authors: Villanueva-Martin Gonzalo , Acosta-Herrera Marialbert , Kerick Martin , López-Isac Elena , Simeón Carmen P. , Callejas José L. , Assassi Shervin , Beretta Lorenzo , SSc Group International , (ASIG) Australian Scleroderma Interest Group , Allanore Yannick , Proudman Susanna M. , Nikpour Mandana , Fonseca Carmen , Denton Christopher P. , Radstake Timothy R. D. J. , Mayes Maureen D. , Jiang Xia , Martin Javier , Bossini-Castillo Lara
Published: October 2022

Obesity contributes to a chronic proinflammatory state, which is a known risk factor to develop immune-mediated diseases. However, its role in systemic sclerosis (SSc) remains to be elucidated. Therefore, we conducted a two-sample mendelian randomization (2SMR) study to analyze the effect of three body fat distribution parameters in SSc. As instrumental variables, we used the allele effects described for single nucleotide polymorphisms (SNPs) in different genome-wide association studies (GWAS) for SSc, body mass index (BMI), waist-to-hip ratio (WHR) and WHR adjusted for BMI (WHRadjBMI). We performed local (pHESS) and genome-wide (LDSC) genetic correlation analyses between each of the traits and SSc and we applied several Mendelian randomization (MR) methods (i.e., random effects inverse-variance weight, MR-Egger regression, MR pleiotropy residual sum and outlier method and a multivariable model). Our results show no genetic correlation or causal relationship between any of these traits and SSc. Nevertheless, we observed a negative causal association between WHRadjBMI and SSc, which might be due to the effect of gastrointestinal complications suffered by the majority of SSc patients. In conclusion, reverse causality might be an especially difficult confounding factor to define the effect of obesity in the onset of SSc.
Oral Anticoagulant Discontinuation and Its Predictors in Patients with Atrial Fibrillation
Authors: Kefale Adane Teshome , Bezabhe Woldesellassie M. , Peterson Gregory M.
Published: October 2022

Background: Oral anticoagulants (OACs) are important in reducing the risk of ischaemic stroke in people with atrial fibrillation (AF). Although patients need to take their OAC continuously, it has been suggested that discontinuation is common in clinical practice, and this could predispose patients to thrombotic complications. Aims: To investigate the rate of OAC discontinuation and its predictors in patients with AF, using national data from Australian general practices. Methods: We analysed data obtained from NPS MedicineWise’s MedicineInsight dataset. We included patients with a recorded diagnosis of AF who newly started an OAC between 1 January 2013 and 31 December 2017. Patients were considered persistent if an OAC was prescribed continuously without discontinuing more than 60 days gap in therapy. The follow-up period was 12 months post-initiation. Multivariable models were used for the analysis of predictors. Results: Of 16,075 patients included in the cohort, 47.3% were females, and the mean age was 74.6 (SD 10.2) years. The overall OAC discontinuation rate was 13.2% (confidence interval (CI) 12.6–13.7%) by 12 months post-initiation. The discontinuation rates for warfarin, apixaban, dabigatran and rivaroxaban were 18.3% (95% CI 17.2–19.5%), 10.1% (95% CI 9.2–11.0%), 10.9% (95% CI 9.4–12.5%) and 12.2% (95% CI 11.4–13.2%), respectively. Warfarin had a significantly higher risk of discontinuation compared to direct-acting OACs. Factors that are known to increase the risk of stroke (older age, diabetes, and hypertension) were associated with better persistence. Conclusions: A relatively high proportion of patients with AF continued OAC therapy by 12 months post-initiation. Positively, patients with the highest risk of stroke and lowest risk of bleeds seemed to have better persistence.
Quantitative Flow Ratio Is Related to Anatomic Left Main Stem Lesion Parameters as Assessed by Intravascular Imaging
Authors: Milzi Andrea , Dettori Rosalia , Lubberich Richard Karl , Burgmaier Kathrin , Marx Nikolaus , Reith Sebastian , Burgmaier Mathias
Published: October 2022

Introduction: Previously, an association between anatomic left main stem (LMS) lesion parameters, as described by intravascular ultrasound (IVUS) and fractional flow reserve (FFR), was shown. Quantitative flow ratio (QFR) is a novel, promising technique which can assess functional stenosis relevance based only on angiography. However, as little is known about the relationship between anatomic LMS parameters and QFR, it was thus investigated in this study. Methods: In 53 patients with LMS disease, we tested the association between anatomic assessment using OCT (n = 28) or IVUS (n = 25) on the one hand and functional assessment as determined by QFR on the other hand. LMS-QFR was measured using a dedicated approach, averaging QFR over left anterior descending (LAD) and circumflex (LCX) and manually limiting segment of interest to LMS. Results: The minimal luminal area of the LMS (LMS-MLA) as measured by intravascular imaging showed a consistent correlation with QFR (R = 0.61, p < 0.001). QFR could predict a LMS-MLA < 6 mm2 with very good diagnostic accuracy (AUC 0.919) and a LMS-MLA < 4.5 mm2 with good accuracy (AUC 0.798). Similar results were obtained for other stenosis parameters. Conclusions: QFR might be a valuable tool to assess LMS disease. Further studies focusing on patient outcomes are needed to further validate the effectiveness of this approach.
Drilling-Induced Damages in Hybrid Carbon and Glass Fiber-Reinforced Composite Laminate and Optimized Drilling Parameters
Authors: Natarajan Elango , Markandan Kalaimani , Sekar Santhosh Mozhuguan , Varadaraju Kaviarasan , Nesappan Saravanakumar , Albert Selvaraj Anto Dilip , Lim Wei Hong , Franz Gérald
Published: October 2022

Hybrid carbon and glass fiber-reinforced composites have attracted significant research interest for primary load-bearing structural components in the field of aviation manufacturing owing to their low weight and high strength to weight ratio. However, the anisotropic and heterogenic nature of carbon and/or glass fiber-reinforced composite prevents high machining quality due to the directionality effect of fibers in the polymer matrix. As such, this study investigates the effect of drilling process for hybrid fiber-reinforced composite and reports optimal drilling parameters to improve the drill quality. Experimental studies indicate that an increased point angle (i.e., from 80° to 120°) resulted in low delamination upon entry due to reduced thrust force, which in turn produces better surface finish with minimal tool wear. The optimal feed rate (0.2 mm/min) ensures lower delamination at entry, since higher feed rates can increase the thrust force due to elevation in the shear area or raise the self-generated feed angle, which in turn reduces the effective clearance angle. To this end, drilling parameters were optimized using Dandelion optimizer (DO)—a cutting-edge metaheuristic search algorithm (MSA). We report the excellent consistency of DO to solve the proposed drilling optimization problem while achieving promising results as ascertained by the small standard deviation values.
Sparse Optical Flow Implementation Using a Neural Network for Low-Resolution Thermal Aerial Imaging
Authors: Nguyen Tran Xuan Bach , Chahl Javaan
Published: October 2022

This study is inspired by the widely used algorithm for real-time optical flow, the sparse Lucas–Kanade, by applying a feature extractor to decrease the computational requirement of optical flow based neural networks from real-world thermal aerial imagery. Although deep-learning-based algorithms have achieved state-of-the-art accuracy and have outperformed most traditional techniques, most of them cannot be implemented on a small multi-rotor UAV due to size and weight constraints on the platform. This challenge comes from the high computational cost of these techniques, with implementations requiring an integrated graphics processing unit with a powerful on-board computer to run in real time, resulting in a larger payload and consequently shorter flight time. For navigation applications that only require a 2D optical flow vector, a dense flow field computed from a deep learning neural network contains redundant information. A feature extractor based on the Shi–Tomasi technique was used to extract only appropriate features from thermal images to compute optical flow. The state-of-the-art RAFT-s model was trained with a full image and with our proposed alternative input, showing a substantial increase in speed while maintain its accuracy in the presence of high thermal contrast where features could be detected.
Familiar Strategies Feel Fluent: The Role of Study Strategy Familiarity in the Misinterpreted-Effort Model of Self-Regulated Learning
Authors: Macaluso Jessica A. , Beuford Ramya R. , Fraundorf Scott H.
Published: October 2022

Why do learners not choose ideal study strategies when learning? Past research suggests that learners frequently misinterpret the effort affiliated with efficient strategies as being indicative of poor learning. Expanding on past findings, we explored the integration of study habits into this model. We conducted two experiments where learners experienced two contrasting strategies—blocked and interleaved schedules—to learn to discriminate between images of bird families. After experiencing each strategy, learners rated each according to its perceived effort, learning, and familiarity. Next, learners were asked to choose which strategy they would use in the future. Mediation analyses revealed, for both experiments, that the more mentally effortful interleaving felt, the less learners felt they learned, and the less likely learners were to use it in future learning. Further, in this study, strategy familiarity predicted strategy choice, also mediated by learners’ perceived learning. Additionally, Study 2 verified that, in contrast to learners’ judgments, the less familiar interleaving schedule resulted in better learning. Consequently, learners are making ineffective learning judgments based on their perceptions of effort and familiarity and, therefore, do not make use of optimal study strategies in self-regulated learning decisions.
Why Hasn’t the Gifted Label Caught up with Science?
Authors: Matthews Michael S. , Jolly Jennifer L.
Published: October 2022

The development of both special education and gifted education as fields of study were closely tied to the origins of intelligence testing in the early 20th century. While special education’s terminology has become more nuanced and circumspect over the ensuing century, the term gifted has remained unchanged despite coming under substantial criticism in recent decades for its lack of specificity and for the innateness that the term implies as the primary cause of individual differences in ability. We examine this history and the seminal nationally disseminated reports related to gifted education, from the Marland report to the present, to consider why the gifted label has persisted. We conclude with some suggestions for how these issues might be remedied.
First Isolation of Pseudogymnoascus destructans, the Fungal Causative Agent of White-Nose Syndrome, in Korean Bats (Myotis petax)
Authors: Kim Young-Sik , Yang Myun-Sik , Jeong Chang-Gi , Chung Chul-Un , Oem Jae-Ku
Published: October 2022

White-nose syndrome (WNS), caused by Pseudogymnoascus destructans (Pd), is a lethal fungal disease that affects hibernating bats in North America. Recently, the presence of Pd was reported in countries neighboring Korea. However, Pd has not been investigated in Korea. Therefore, this study aimed to identify the presence of Pd in Korean bats. Altogether, wings from 241 bats were collected from 13 cities and cultured. A total of 79 fungal colonies were isolated, and two isolates were identified as Pd using polymerase chain reaction. Of the nine bat species captured in 13 cities, Pd was isolated only from Myotis petax in Goryeong. Atypical, curved conidia were observed in two isolated fungal colonies. Although histological lesions were not observed by hematoxylin and eosin or periodic acid–Schiff staining, fungal invasion was observed in the tissue sections. Taken together, these results confirmed the presence of Pd in Korean bats and suggest the possibility of WNS outbreaks in Korean bats. This is the first report of the isolation and molecular analysis of Pd from Korean bats.