bluuebunny/crossref_metadata_2025 huggingface dataset:
Oxidation of Airborne m-Xylene in Pulsed Corona Discharge: Impact of Water Sprinkling
Authors: Altof Kristen , Krichevskaya Marina , Preis Sergei , Bolobajev Juri
Published: October 2024

Plasma from electric discharges can be used in the abatement of volatile organic compounds (VOCs). The application of gas-phase pulsed corona discharge (PCD) in air–water mixtures provides favorable conditions for the oxidation of VOCs at unsurpassed energy efficiency. This research investigates the impact of water sprinkling on PCD performance in the oxidation of m-xylene as a model compound. Experimental research into the plasma treatment of continuous air flow was undertaken using the PCD reactor in dry and water-sprinkled modes. Water sprinkling more than doubled the m-xylene oxidation rate, which can be attributed to abundant OH-radicals produced at the plasma–water interface. Water sprinkling substantially reduced the formation of nitrous oxide, which is considered to be a secondary pollutant in the outlet air. Ozone is considered a by-product helping the subsequent photocatalytic oxidation of potential residues and photocatalyst maintenance. The use of water-sprinkled PCD is a promising approach to energy-efficient abatement of VOCs.
A Fluorescence Strategy Based on Guanidinylated Carbon Dots and FAM-Labeled ssDNA for Facile Detection of Lipopolysaccharide
Authors: Zheng Zongfu , Li Junrong , Pan Gengping , Wang Jing , Wang Yao , Peng Kai , Zhang Xintian , Huang Zhengjun , Weng Shaohuang
Published: October 2024

The detection of lipopolysaccharide (LPS) has important value for the monitoring of diseases such as sepsis and the impurity control of drugs. In this work, we prepared guanidinylated carbon dots (GQ-CDs) and used them to adsorb 5-carboxyfluorescein (FAM)-labeled single-stranded DNA (ssDNA) to become GQ-CDs/FAM-DNA, resulting in quenched FAM. The quenching efficiency of the FAM-DNA by GQ-CDs in the GQ-CDs/FAM-DNA system was 91.95%, and this quenching was stable over the long term. Upon the addition of LPS, the quenched FAM-DNA in the GQ-CDs/FAM-DNA system regained fluorescence at 520 nm. The mechanism studies found that the addition of LPS promoted the dissociation of FAM-DNA adsorbed on GQ-CDs, thereby restoring fluorescence. The degree of fluorescence recovery was closely related to the content of LPS. Under optimized conditions, the fluorescence recovery was linearly related to LPS concentrations ranging from 5 to 90 μg/mL, with a detection limit of 0.75 μg/mL. The application of this method to plasma samples and trastuzumab injections demonstrated good spiked recoveries and reproducibility. This platform, based on GQ-CDs for the adsorption and quenching of FAM-DNA, enables the detection of LPS through relatively simple mixing operations, showing excellent competitiveness for the determination of actual samples under various conditions.
Application of a Novel Disposable Flow Cell for Spectroscopic Bioprocess Monitoring
Authors: Steinwedel Tobias , Raithel Philipp , Schellenberg Jana , Kortmann Carlotta , Gellermann Pia , Belz Mathias , Solle Dörte
Published: October 2024

The evaluation of the analytical capabilities of a novel disposable flow cell for spectroscopic bioprocess monitoring is presented. The flow cell is presterilized and can be connected to any kind of bioreactor by weldable tube connections. It is clamped into a reusable holder, which is equipped with SMA-terminated optical fibers or an integrated light source and detection unit. This modular construction enables spectroscopic techniques like UV-Vis spectroscopy or turbidity measurements by scattered light for modern disposable bioreactors. A NIR scattering module was used for biomass monitoring in different cultivations. A high-cell-density fed-batch cultivation with Komagataella phaffii and a continuous perfusion cultivation with a CHO DG44 cell line were conducted. A high correlation between the sensor signal and biomass or viable cell count was observed. Furthermore, the sensor shows high sensitivity during low turbidity states, as well as a high dynamic range to monitor high turbidity values without saturation effects. In addition to upstream processing, the sensor system was used to monitor the purification process of a monoclonal antibody. The absorption module enables simple and cost-efficient monitoring of downstream processing and quality control measurements. Recorded absorption spectra can be used for antibody aggregate detection, due to an increase in overall optical density.
Thermochromic Polymers in Food Packaging: A Comprehensive Systematic Review and Patent Landscape Analysis
Authors: Breheny Colette , Donlon Kieran , Harrington Alan , Colbert Declan Mary , Bezerra Gilberto S. N. , Geever Luke M.
Published: October 2024

This study addresses the gap in research on the application of thermochromic polymers (TPs) in food packaging and their potential for real-time temperature monitoring, aiding in the assessment of food quality and shelf-life. TPs exhibit a visible color change in response to temperature variations. A comprehensive systematic review (SR) across multiple engineering peer-review databases using predefined terms was conducted. Additionally, international patent databases were investigated using the same predefined terms. Independent experts reviewed the methodology to identify and address potential biases. A total of 288 eligible articles and 922 patents were identified. After a duplicate selection and extraction process according to the inclusion criteria, four related full-text publications were selected from the initial 288 articles, and five relevant patents were selected from the 922 patents. The qualitative review suggests that TPs hold significant promise as food packaging materials due to their unique physical properties. The study concludes that TPs offer valuable properties for the food packaging industry, meriting further investigation to exploit their benefits fully.
Surface Tribological Properties Enhancement Using Multivariate Linear Regression Optimization of Surface Micro-Texture
Authors: Ge Zhenghui , Hu Qifan , Zhu Haitao , Zhu Yongwei
Published: October 2024

This work aims to provide a comprehensive understanding of the structural impact of micro-texture on the properties of bearing capacity and friction coefficient through numerical simulation and theoretical calculation. Compared to the traditional optimization method of single-factor analysis (SFA) and orthogonal experiment, the multivariate linear regression (MLA) algorithm can optimize the structure parameters of the micro-texture within a wider range and analyze the coupling effect of the parameters. Therefore, in this work, micro-textures with varying texture size, area ratio, depth, and geometry were designed, and their impact on the bearing capacity and friction coefficient was investigated using SFA and MLA algorithms. Both methods obtained the optimal structures, and their properties were compared. It was found that the MLA algorithm can further improve the friction coefficient based on the SFA results. The optimal friction coefficient of 0.070409 can be obtained using the SFA method with a size of 500 µm, an area ratio of 40%, a depth of 5 µm, and a geometry of the slit, having a 10.7% reduction compared with the texture-free surface. In comparison, the friction coefficient can be further reduced to 0.067844 by the MLA algorithm under the parameters of size of 600 µm, area ratio of 50%, depth of 9 µm, and geometry of the slit. The final optimal micro-texture surface shows a 15.6% reduction in the friction coefficient compared to the texture-free surfaces and a 4.9% reduction compared to the optimal surfaces obtained by SFA.
An Alternative Approach to Validate the Cleaning Efficiency of a Skin Cleansing Wipe
Authors: Marisa Arnold , Shadrach Wisdom , Holohan Kerrie , Abu Alhaija Abed Alkarem , Gilligan Emer , Sommerville Jill , Burke Niall , Yeomans Tim
Published: October 2024

A key functionality for cleansing wipes is their efficiency in removing dirt and microbial contamination from the skin to safe or non-detectable levels, traditionally determined using the gravimetric method, which has been reported to be prone to experimental errors. This study evaluates the efficiency of a water-based cleansing wipe, WaterWipes® (WaterWipes, UC, Drogheda, Ireland), for removing synthetic faecal matter (FecloneTM, SiliClone Creations LLC, Havertown, PA, United States) and Escherichia coli (NCTC 10538) from volunteers’ skin, the former using a dermal analytical device called the Antera 3DTM camera (Miravex Ltd., Dublin, Ireland), and the latter using standard microbiological methods. FecloneTM was applied to participants’ forearms and the Antera 3DTM camera captured detailed images of the skin surface before and after wiping. The Antera 3DTM camera approach was found to be effective in measuring cleaning efficiency, with the wipe removing all detectable traces of the FecloneTM applied. The total pore area (mm2), pore count, and total pore volume (mm3) in test participants post-wiping were observed to be reduced on average by 39.05%, 34.39%, and 39.98%, respectively. The wipe removed 99.99% of E. coli (NCTC 10538) applied, as measured using the microbial plate count method. In conclusion, the Antera 3DTM camera method was observed to be effective in evaluating removal of topically applied FecloneTM.
Alpha-Bisabolol-Loaded Cosmetic Micellar Solution with Cleansing and Antimicrobial Action for Facial Skin Hygiene
Authors: Ivanova Nadezhda , Ermenlieva Neli , Andonova Velichka
Published: October 2024

The current research is focused on the discovery and optimization of an effective cosmetic carrier of alpha-bisabolol as a first step in the development of a cosmetic product with cleansing and antimicrobial action for facial skin hygiene. A micellar solution of Poloxamer 407 was selected as a cosmetic base because of the good washing ability, easy application, and high tolerability of this polymeric surfactant. The solubilization capacity of a 5% micellar solution with respect to α-bisabolol was investigated by applying varying solubilization techniques and increasing concentrations of the oily active substance. The test samples were subjected to an accelerated physical stability test, viscosimetry, dynamic light scattering (DLS), electrophoretic light scattering (ELS), foamability test, and antimicrobial screening. Over the course of this research, the advantage of the film-hydration method over direct solubilization was demonstrated by the narrower size distribution and smaller hydrodynamic size of the micellar nano-carriers (ranging from 29.02 to 116.5 nm) and the respective higher physical stability of the dispersions. The optimized composition was found to be suitable for application on large skin areas in terms of viscosity in the temperature range from 20 °C to 40 °C (3.4–2.3 mPa.s). Preservation of the washing capacity of the micellar solution in the presence of solubilized α-bisabolol was established. The active composition demonstrated inhibitory activity against Staphylococcus aureus and Escherichia coli and fungicidal activity against Candida albicans. This study concludes that the optimal concentration of α-bisabolol to be solubilized in a 5% Poloxamer 407 micellar solution by the film-hydration technique is 1%, considering the desirable physical endurance and antimicrobial activity.
High-Performance Broadband Photodetectors Combining Perovskite and Organic Bulk Heterojunction Bifunctional Layers
Authors: Li Tengteng , Wu Huijia , Hao Yafeng , Ma Fupeng , Zhu Pu , Li Ziwei , Li Fengchao , Yu Jiangang , Liu Meihong , Lei Cheng , Liang Ting
Published: October 2024

Perovskite can be used to prepare high-performance photodetectors due to its excellent optical properties. However, the detection range of perovskite photodetectors is mostly limited to the visible light range, restricting their further development and application. In recent years, combining perovskite with organic bulk heterojunctions to prepare photodetectors with broadband detection capability has proven to be an effective strategy. Through this approach, the response spectrum of the photodetector can be flexibly regulated, and organic compounds can improve the perovskite film quality by passivating defects and inhibit the penetration of water molecules in the air, thereby improving the device performance and stability. In this work, we propose and demonstrate the feasibility of combining MAPbI3 perovskite with PTB7-Th:COTIC-4F to prepare high-performance photodetectors with wide spectral response characteristics. With the assistance of an organic bulk heterojunction, the defects of perovskite crystals are effectively passivated, and the detection spectrum of the device is successfully extended to about 1100 nm. As a result, the responsivity achieved is 0.58 A/W, 1.19 A/W, and 1.41 A/W under laser illumination of 532 nm, 808 nm, and 980 nm, with the power density of 5 μW/cm2 at the bias voltage of −0.5 V, respectively, which is one of the best performances among vertical device structures of this type. Moreover, the stability of the final hybrid film has been greatly improved. This work provides a new approach to the preparation of high-performance and broadband perovskite photodetectors.
Influence of Hematocrit and Storage Temperature on the Stability of Dried Blood Samples in Serological Analyses of Tetanus, Diphtheria, and Pertussis
Authors: Rodríguez-Mateos Mariano , Carlos Silvia , Jaso Javier , Holguín África , Reina Gabriel
Published: October 2024

Background: Dried blood spots (DBSs) enable the study of serological markers of various pathogens without the need to obtain serum/plasma through venipuncture. Methods: Sixty-four blood samples were prepared on Whatman™ 903 cards using specimens obtained by venipuncture to study the detection of serological markers of diphtheria, tetanus, and pertussis in DBSs, and their stability 4 months post-collection. An automated chemiluminescent immunoassay was used to investigate diphtheria, tetanus, and pertussis IgG levels from both DBSs and plasma samples. Results: An optimal cut-off value for DBSs was calculated to improve the performance of diphtheria and tetanus serological markers in DBSs, achieving high sensitivity (95% and 98%, respectively) and specificity (91.7% and 92.3%, respectively). No protection against pertussis was found in the population studied. The correlation observed between the plasma and the DBSs processed after sample collection was high (0.967–0.970) for all antibodies studied except pertussis (0.753), both considering hematocrit before sample elution or not. The correlation between DBSs and plasma for diphtheria and tetanus remained strong following a 4-month delay in DBS processing at 4 °C (0.925–0.964) and −20 °C (0.924–0.966), with only a minor decrease observed for diphtheria at room temperature (0.889), while maintaining a strong correlation for tetanus (0.960). For pertussis, the correlation between DBSs and plasma was drastically reduced after delaying its processing for 4 months at any temperature. Conclusions: To summarize, hematocrit levels within the normal range do not affect the processing of DBSs in the study of serological markers of diphtheria, tetanus, and pertussis. The DBS stability for serological diagnosis of diphtheria and tetanus is adequate when samples are stored at −20 °C for a period of 4 months. The pertussis serological marker does not appear to remain stable after 4 months, even when the DBS is stored frozen at −20 °C.
Cytokine Storms and Anaphylaxis Following COVID-19 mRNA-LNP Vaccination: Mechanisms and Therapeutic Approaches
Authors: Awaya Toru , Hara Hidehiko , Moroi Masao
Published: October 2024

Acute adverse reactions to COVID-19 mRNA vaccines are a major concern, as autopsy reports indicate that deaths most commonly occur on the same day of or one day following vaccination. These acute reactions may be due to cytokine storms triggered by lipid nanoparticles (LNPs) and anaphylaxis induced by polyethene glycol (PEG), both of which are vital constituents of the mRNA-LNP vaccines. Kounis syndrome, in which anaphylaxis triggers acute coronary syndrome (ACS), may also be responsible for these cardiovascular events. Furthermore, COVID-19 mRNA-LNP vaccines encompass adjuvants, such as LNPs, which trigger inflammatory cytokines, including interleukin (IL)-1β and IL-6. These vaccines also produce spike proteins which facilitate the release of inflammatory cytokines. Apart from this, histamine released from mast cells during allergic reactions plays a critical role in IL-6 secretion, which intensifies inflammatory responses. In light of these events, early reduction of IL-1β and IL-6 is imperative for managing post-vaccine cytokine storms, ACS, and myocarditis. Corticosteroids can restrict inflammatory cytokines and mitigate allergic responses, while colchicine, known for its IL-1β-reducing capabilities, could also prove effective. The anti-IL-6 antibody tocilizumab also displays promising treatment of cytokine release syndrome. Aside from its significance for treating anaphylaxis, epinephrine can induce coronary artery spasms and myocardial ischemia in Kounis syndrome, making accurate diagnosis essential. The upcoming self-amplifying COVID-19 mRNA-LNP vaccines also contain LNPs. Given that these vaccines can cause a cytokine storm and allergic reactions post vaccination, it is crucial to consider corticosteroids and measure IL-6 levels for effective management.
CDX2-Suppressed Colorectal Cancers Possess Potentially Targetable Alterations in Receptor Tyrosine Kinases and Other Colorectal-Cancer-Associated Pathways
Authors: Voutsadakis Ioannis A.
Published: October 2024

Background: Colorectal cancer, a prevalent gastrointestinal carcinoma, has a high risk for recurrence when locally advanced and remains lethal when in an advanced stage. Prognostic biomarkers may help in better delineating the aggressiveness of this disease in individual patients and help to tailor appropriate therapies. CDX2, a transcription factor of gastrointestinal differentiation, has been proposed as a biomarker for good outcomes and could also be a marker of specific sub-types amenable to targeted therapies. Methods: Colorectal cancers from The Cancer Genome Atlas (TCGA) colorectal cohort and colon cancers from the Sidra-LUMC AC-ICAM cohort were categorized according to their expressions of CDX2 mRNA. Groups with CDX2 suppression were compared with cancers showing no suppression regarding their clinical and genomic characteristics. Results: CDX2-suppressed colorectal cancers showed a high prevalence of Microsatellite Instability (MSI) and a lower prevalence of chromosomal Instability (CIN) compared to non-CDX2-suppressed cancers. In addition, CDX2-suppressed cancers had a higher prevalence of mutations in several receptor tyrosine kinase genes, including EGFR, ERBB3, ERBB4, RET, and ROS1. In contrast, CDX2-suppressed cancers displayed lower mutation frequencies than non-CDX2-suppressed cancers in the genes encoding for the two most frequently mutated tumor suppressors, APC and TP53, and the most frequently mutated colorectal cancer oncogene, KRAS. However, CDX2-suppressed colorectal cancers had a higher prevalence of mutations in alternative genes of the WNT/APC/β-catenin and KRAS/BRAF/MEK pathways. In addition, they showed frequent mutations in DNA damage response (DDR) genes, such as BRCA2 and ATM. Conclusion: CDX2-suppressed colorectal cancers constitute a genomically distinct subset of colon and rectal cancers that have a lower prevalence of KRAS, APC, and TP53 mutations, but a high prevalence of mutations in less commonly mutated colorectal cancer genes. These alterations could serve as targets for personalized therapeutics in this subset.
Complete Androgen Insensitivity Syndrome in a Young Girl with Primary Amenorrhea and Suspected Delayed Puberty: A Case-Based Review of Clinical Management, Surgical Follow-Up, and Oncological Risk
Authors: Fraccascia Barbara , Sodero Giorgio , Pane Lucia Celeste , Malavolta Elena , Gola Caterina , Pane Luigi , Paradiso Valentina Filomena , Nanni Lorenzo , Rigante Donato , Cipolla Clelia
Published: October 2024

Background: Complete androgen insensitivity syndrome (CAIS) is a rare disorder of sex development characterized by 46,XY karyotype and testes, yet presenting with a complete female phenotype, which is related to mutations in the androgen receptor (AR) gene. Case presentation: We herein present the case of a 14-year-old adolescent with primary amenorrhea and suspected delayed puberty whose diagnostic journey led to the identification of CAIS through the demonstration of a novel AR variant (c.159_207del). Case-based review: Our report encompasses the complexity of CAIS management, focusing on the risk of malignancy, surveillance options, hormone replacement therapy, timing of an eventual gonadectomy, and the psychosocial impact of such a diagnosis. An algorithm has been formulated for the management of CAIS starting in adolescence, highlighting the conservative approach for those patients unwilling to undergo gonadectomy. Conclusions: Primary amenorrhea and delay in puberty development may provide clues, ultimately leading to a diagnosis of CAIS. This review emphasizes the cruciality of a multidisciplinary approach in managing patients with CAIS, needing for an individualized care to optimize the overall outcome.
Evolution of Unmanned Surface Vehicle Path Planning: A Comprehensive Review of Basic, Responsive, and Advanced Strategic Pathfinders
Authors: Chu Yijie , Gao Qizhong , Yue Yong , Lim Eng Gee , Paoletti Paolo , Ma Jieming , Zhu Xiaohui
Published: October 2024

Unmanned Surface Vehicles (USVs) are rapidly becoming mission-indispensable for a variety of naval operations, from search and rescue to environmental monitoring and surveillance. Path planning lies at the heart of the operational effectiveness of USVs, since it represents the key technology required to enable the vehicle to transit the unpredictable dynamics of the marine environment in an efficient and safe way. The paper develops a critical review of the most recent advances in USV path planning and a novel classification of algorithms according to operational complexity: Basic Pathfinders, Responsive Pathfinders, and Advanced Strategic Pathfinders. Each category can adapt to different requirements, from environmental predictability to the desired degree of human intervention, and from stable and controlled environments to highly dynamic and unpredictable conditions. The review includes current methodologies and points out the state-of-the-art algorithmic approaches in their experimental validations and real-time applications. Particular attention is paid to the description of experimental setups and navigational scenarios showing the realistic impact of these technologies. Moreover, this paper goes through the key, open challenges in the field and hints at the research direction to leverage in order to enhance the robustness and adaptability of path planning algorithms. This paper, by offering a critical analysis of the current state-of-the-art, lays down the foundation of future USV path planning algorithms.
Assessment of Staining Patterns in Facades Using an Unmanned Aerial Vehicle (UAV) and Infrared Thermography
Authors: Ferreira João Arthur dos Santos , Carrilho Fernanda Ramos Luiz , Alcantara Jean Augusto Ortiz , Gonçalves Camile , Stolz Carina Mariane , Amario Mayara , Haddad Assed N.
Published: October 2024

The emergence of pathological manifestations on facades persists globally, with recurring failures occurring often due to repeated construction details or design decisions. This study selected a building with a recurring architectural design and evaluated the stain pattern on its facade using a UAV with an infrared thermal camera. The results showed that advanced technology offers a non-invasive and efficient approach for comprehensive inspections, enabling early detection and targeted interventions to preserve architectural assets without requiring ancillary infrastructure or risking workers at height. The precise identification of damage clarified the real causes of the observed pathological manifestations. Capturing the images allowed accurate inspection, revealing hollow and damp spots not visible to the human eye. Novel results highlight patterns in the appearance of dirt on facades, related to water flow that could have been redirected through proper geometric element execution. The presented inspection methodology, staining standards, and construction details can be easily applied to any building, regardless of location. Sills, drip pans, and flashings must have drip cuts, adequate inclination, and projections to prevent building degradation.
Data-Driven Modeling of DC–DC Power Converters
Authors: Silva-Vera Edgar D. , Valdez-Resendiz Jesus E. , Escobar Gerardo , Guillen Daniel , Rosas-Caro Julio C. , Sosa Jose M.
Published: October 2024

This article presents a data-driven methodology for modeling DC–DC power electronic converters. Using the proposed methodology, the dynamics of a converter can be captured, thereby eliminating the need for explicit theoretical modeling methods. This approach only requires the acquisition of fundamental measurements: currents through inductors and voltages across capacitors. The acquired data are used to construct a linear difference system, which is algebraically manipulated to form a state–space representation of the converter under analysis. Three DC–DC converter topologies were analyzed, and their resulting models were tested and compared with simulation data, yielding an average error deviation of approximately 2% for current signals and 4% for voltage signals, demonstrating precise tracking of the actual dynamics. The proposed data-driven methodology could simplify the implementation of adaptive control strategies in larger-scale solutions or in the interconnection of multiple converters.
Digital Therapeutics for Patients with Mild Cognitive Impairment: Design of a Mobile Health Program
Authors: Choi Hayeong , Shin JaeKyoung , Kim Ji Hye , Lee Byoung-Kwon , Lee Sang-Kyu , Ahn Moo-Eob , Kim Yeo Jin
Published: October 2024

Background: For patients with mild cognitive impairment (MCI), a multidomain intervention that integrates physical activity, cognitive training, and dietary intervention is necessary to delay cognitive decline. The proliferation of smartphones, software development, and online service improvements now enable the delivery of online intervention programs and the concurrent collection of patient-generated data. This paper aims to report on a protocol for developing a smartphone-based multidomain intervention tailored to the level of patients with MCI. Methods: Our program targeted patients with MCI aged 60–79. The physical activity domain provides training that is appropriate for the patient’s strength and fitness levels. The cognitive training uses both verbal and nonverbal stimuli to stimulate various domains of cognitive function. It was designed to match tasks to the patient’s abilities, promoting motivational growth. Dietary interventions were designed to enable patients to plan their diet and learn to adopt appropriate eating habits. Results: We designed and organized a screen for home aerobic exercise, story quizzes, nonverbal cognitive training, and memory diary screens. Conclusions: We developed a smartphone application-based multidomain intervention program to delay cognitive decline in patients with MCI. We will verify its efficacy in future clinical trials.
Carrier Mobility Enhancement in Ultrathin-Body InGaAs-on-Insulator n-Channel Metal-Oxide-Semiconductor Field-Effect Transistors Based on Dual-Gate Modulation
Authors: Tang Xiaoyu , Liu Yujie , Han Zhezhe , Hua Tao
Published: October 2024

As a promising candidate for More Moore technology, InGaAs-based n-channel metal-oxide-semiconductor field-effect transistors (nMOSFETs) have attracted growing research interest, especially with InGaAs-on-insulator (InGaAs-OI) configurations aimed at alleviating the short channel effects. Correspondingly, the fabrication of an ultrathin InGaAs body becomes necessary for the full depletion of the channel, while the deteriorated semiconductor–insulator interface-related scattering could severely limit carrier mobility. This work focuses on the exploration of carrier mobility enhancement strategies for 8 nm body-based InGaAs-OI nMOSFETs. With the introduction of a bottom gate bias on the substrate side, the conduction band structure in the channel was modified, relocating the carrier wave function from the InGaAs/Al2O3 interface into the body. Resultantly, the channel mobility with an inversion layer carrier concentration of 1 × 1013 cm−2 was increased by 62%, which benefits InGaAs-OI device application in monolithic 3D integration. The influence of the dual-gate bias from front gate and bottom gate on gate stability was also investigated, where it has been unveiled that the introduction of the positive bottom gate bias is also beneficial for gate stability with an alleviated orthogonal electric field.
Intelligent Traffic Control Decision-Making Based on Type-2 Fuzzy and Reinforcement Learning
Authors: Bi Yunrui , Ding Qinglin , Du Yijun , Liu Di , Ren Shuaihang
Published: October 2024

Intelligent traffic control decision-making has long been a crucial issue for improving the efficiency and safety of the intelligent transportation system. The deficiencies of the Type-1 fuzzy traffic control system in dealing with uncertainty have led to a reduced ability to address traffic congestion. Therefore, this paper proposes a Type-2 fuzzy controller for a single intersection. Based on real-time traffic flow information, the green timing of each phase is dynamically determined to achieve the minimum average vehicle delay. Additionally, in traffic light control, various factors (such as vehicle delay and queue length) need to be balanced to define the appropriate reward. Improper reward design may fail to guide the Deep Q-Network algorithm to learn the optimal strategy. To address these issues, this paper proposes a deep reinforcement learning traffic control strategy combined with Type-2 fuzzy control. The output action of the Type-2 fuzzy control system replaces the action of selecting the maximum output Q-value of the target network in the DQN algorithm, reducing the error caused by the use of the max operation of the target network. This approach improves the online learning rate of the agent and increases the reward value of the signal control action. The simulation results using the Simulation of Urban MObility platform show that the traffic signal optimization control proposed in this paper has achieved significant improvement in traffic flow optimization and congestion alleviation, which can effectively improve the traffic efficiency in front of the signal light and improve the overall operation level of traffic flow.
Topicalities in the Forest Ecology of Seeds
Authors: Šerá Božena
Published: October 2024

The main task of forest seed farming is to ensure that there is a sufficient number of fruit/seeds of high genetic value from all required tree species for annual management [...]
Current Updates on Lactic Acid Production and Control during Baijiu Brewing
Authors: Zhou Yabin , Hua Jin
Published: October 2024

Lactic acid is closely linked to the safety and quality of baijiu, the traditional Chinese fermented alcoholic beverage. Produced by lactic acid bacteria during fermentation, it creates an acidic environment that inhibits the growth of spoilage organisms and harmful microbes, thereby enhancing the safety and stability of the final product. Additionally, lactic acid is a key contributor to baijiu’s flavor profile, providing a smooth and rounded taste. Its levels can significantly impact consumer experience. An excess of lactic acid can result in a sour, undesirable flavor, while insufficient levels may lead to a flat and less appealing taste. Maintaining balanced lactic acid levels is crucial for ensuring that baijiu is both safe and enjoyable to drink, ultimately contributing to the product’s success and marketability. This paper reviews the mechanisms of lactic acid production in baijiu, examines its effects on flavor and the potential causes of imbalances, explores regulatory measures for controlling lactic acid during brewing, and discusses the impact of these measures on baijiu’s quality, taste, and yield, along with practical applications by various distilleries. The goal of this paper is to provide a reference for regulating lactic acid in the baijiu production processes.
Preparation and Evaluation of Physical and Chemical Properties of Resin Plugging System Suitable for Formation Plugging of Malignant Lost Circulation
Authors: Gao Wei , Wang Mo , Lian Shixin , Bai Yingrui , Yang Jingbin
Published: October 2024

Lost circulation is one of the important problems that restricts the speed and efficiency of oil and gas drilling and production. In this study, a resin plugging system was successfully developed for lost circulation formation. The resin plugging system showed excellent performance under high temperature and pressure conditions. The experimental results showed that the compressive strength of the resin plugging material can reach 9.23 MPa after curing, which is significantly higher than that of the traditional polymer gel material. The resin material can achieve effective curing in the temperature range of 60 °C to 100 °C, and the curing time decreases with the increase of temperature and only needs 3.46 h at 140 °C. The microstructure results showed that the resin material can form a chain or three-dimensional network structure after curing, which can effectively increase the toughness and strength of the cured plugging layer. Infrared and thermogravimetric analysis further confirmed the thermal stability of the chemical bonds in the material, and the initial decomposition temperature was about 241 °C, indicating that it had good thermal stability at about 300 °C. In addition, the effects of curing temperature, salinity, and drilling fluid pollution on the properties of the resin plugging agent were also investigated. The results showed that curing agent dosage and curing temperature are the key factors affecting curing time, while salinity and drilling fluid pollution affect the curing strength and overall properties of the materials. After adding 20% KCl polysulfonate drilling fluid, the compressive strength of the consolidated body decreased to 4.55 MPa. This study can provide an efficient and reliable plugging solution for malignant loss formation.
Influence of Obesity and Sociodemographic Features on the Physical Fitness of Breast Cancer Survivors
Authors: Biskup Malgorzata , Macek Pawel , Zak Marek , Krol Halina , Terek-Derszniak Malgorzata , Gozdz Stanislaw
Published: October 2024

Introduction: Obesity is a chronic, relapsing, and progressive disease. The issue of obesity affects 50 to 80% of patients who have been diagnosed with breast cancer. The aim of this study is to assess the scale of the problem of obesity among breast cancer survivors (BCS) older than 60 years, evaluate their physical fitness, and study the relationship between the occurrence of obesity and levels of fitness among breast cancer survivors. The relationship between fitness and sociodemographic factors has also been analyzed. Materials and Methods: This original epidemiological clinical study included a cohort of 88 female breast cancer survivors treated in 2022 in Holycross Cancer Center, Kielce, Poland. A questionnaire involving demographic information and medical data was utilized. The Senior Fitness Test (SFT) battery has been used to assess the physical fitness of the patients. Body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR), and waist-to-height ratio (WHtR) were also analyzed. Results: More than 70% of the studied breast cancer survivors were classified as overweight or obese, according to BMI and WC indices. Depending on the SFT trial, the regression coefficients indicated worse results in participants who were older, lived in urban areas, were professionally active, less educated, and had higher obesity indices. The analysis of the relationship between obesity indices and fitness components revealed that all obesity indices were significantly associated with lower body flexibility (BMI p = 0.0118, WC p = 0.0092, WHR p = 0.0364, WHtR p = 0.0095). Upper body flexibility was significantly correlated with BMI indices (p = 0.0091, p = 0.0193) and WHtR (p = 0.0095). Agility and balance were significantly associated with WC (p = 0.0193), WHR (p = 0.098), and WHtR (p = 0.0095). Lower body strength was significantly correlated with the WHR index (p = 0.0487). Significant differences were found in upper body strength depending on the WHtR category. Conclusions: In the studied group of breast cancer survivors, there is a high prevalence of overweight and obesity. With increasing obesity rates, older age, and lower education levels, physical activity measured by the SFT decreases. Living in urban areas and being professionally active also predispose to lower physical activity levels. As obesity indices increase, physical fitness decreases in trials assessing upper and lower body strength, upper and lower body flexibility, as well as agility and dynamic balance.
Avian Influenza: Lessons from Past Outbreaks and an Inventory of Data Sources, Mathematical and AI Models, and Early Warning Systems for Forecasting and Hotspot Detection to Tackle Ongoing Outbreaks
Authors: Musa Emmanuel , Nia Zahra Movahhedi , Bragazzi Nicola Luigi , Leung Doris , Lee Nelson , Kong Jude Dzevela
Published: October 2024

Background/Objectives: The ongoing avian influenza (H5N1) outbreak, one of the most widespread and persistent in recent history, has significantly impacted public health and the poultry and dairy cattle industries. This review covers lessons from past outbreaks, risk factors for transmission, molecular epidemiology, clinical features, surveillance strategies, and socioeconomic impacts. Since 1997, H5N1 has infected over 900 individuals globally, with a fatality rate exceeding 50%. Key factors influencing infection rates include demographic, socioeconomic, environmental, and ecological variables. The virus’s potential for sustained human-to-human transmission remains a concern. The current outbreak, marked by new viral clades, has complicated containment efforts. Methods: This review discusses how to integrate technological advances, such as mathematical modeling and artificial intelligence (AI), to improve forecasting, hotspot detection, and early warning systems. Results: We provide inventories of data sources, covering both conventional and unconventional data streams, as well as those of mathematical and AI models, which can be vital for comprehensive surveillance and outbreak responses. Conclusion: In conclusion, integrating AI, mathematical models, and technological innovations into a One-Health approach is essential for improving surveillance, forecasting, and response strategies to mitigate the impacts of the ongoing avian influenza outbreak. Strengthening international collaboration and biosecurity measures will be pivotal in controlling future outbreaks and protecting both human and animal populations from this evolving global threat.
The Relationship between Physical Activity and Quality of Life in Postmenopausal Women: A Cross-Sectional Study
Authors: Tsekoura Maria , Dimitriadis Zacharias , Gridelas Andreas , Sakellaropoulou Argiro , Kolokithas Georgios
Published: October 2024

Background: Postmenopausal women frequently encounter a range of symptoms, including fatigue, diminished physical strength, reduced energy levels, vasomotor symptoms such as hot flushes, and vaginal atrophy, all of which adversely affect their overall quality of life. Engaging in physical activity and structured exercise may effectively alleviate these symptoms and enhance overall well-being. The present study aimed to investigate the relationship between physical activity and quality of life in postmenopausal Greek women. Methods: This cross-sectional clinical study included 219 postmenopausal women. Women with natural menopause for at least 12 consecutive months were enrolled in this descriptive, cross-sectional study. The female participants were asked to fill out the International Physical Activity Questionnaire-short form (IPAQ), the Hospital Anxiety and Depression Scale (HADS), and the EuroQol (EQ-5D-5L) instrument. Anthropometric measurements included weight, height, and waist circumference measurements. Results: A total of 219 postmenopausal women with an age of 61.4 ± 6.1 years and body mass index (BMI) of 25.6 ± 3.7 kg/m2 were studied. Out of the total postmenopausal women studied, 64.8% were physically active. The mean value of MET-min/week was M = 1383.46 ± 1030.12. Physical activity among postmenopausal Greek women showed a strong correlation of PA with quality of life (r = 0.5; p ≤ 0.001) and age (r = 0.55; p ≤ 0.001) and a medium correlation with the HADS (r = 0.4; p ≤ 0.05). Conclusions: There was a 64.8% prevalence of physically active postmenopausal Greek women. The findings underscore the significance of fostering physical activity and quality of life among postmenopausal women to formulate efficacious therapeutic interventions. The results demonstrate a correlation between physical activity and the age of female participants, quality of life, and the HADS and can be used to improve postmenopausal women’s physical activity levels, which is recommended as a strategy for improving the quality of life in postmenopausal women.
The Relationship of the Lower Ribcage with Liver and Gut Size: Implications for Paleoanthropology
Authors: Uy Jeanelle , Beresnevičiūtė Gabrielė , Nguyen Vyvy
Published: October 2024

Organ–skeleton relationships are understudied in biological anthropology. The torso skeleton is often used to infer the organ size and evolution in hominins; ribcage “types”, in particular, are used to infer the abdominal organ size in hominins. This study is a quantitative examination of the relationship between the lower ribcage and two organs: the liver and the intestines (“gut”) in humans. Specifically, we test whether the ribcage breadth, shape, and “flare”, at the level of rib 10, covaries with the liver volume and gut volume in Homo sapiens. Liver size, gut size, and ribcage measurements are taken from CT scans (N = 61). The results show sex differences in the gut–ribcage relationship. The gut volume is associated with ribcage breadth and flare in both sexes. The liver volume is not associated with any ribcage measurements. We conclude that sex differences in the organ–skeleton relationship complicate the previous simplistic view that the size of the liver or the gut could be inferred through a fossil’s ribcage type. Biological anthropologists should continue to explore sex differences in organ–skeleton relationships, when attempting to understand the evolution of visceral organs and the torso.
Declines in Brook Trout Abundance Linked to Atmospheric Warming in Maryland, USA
Authors: Hitt Nathaniel P. , Rogers Karli M. , Kelly Zachary A.
Published: October 2024

Salmonid fishes provide an important indicator of climate change given their reliance on cold water. We evaluated temporal changes in the density of stream-dwelling brook trout (Salvelinus fontinalis) from surveys conducted over a 36-year period (1988–2023) by the Maryland Department of Natural Resources in Eastern North America. Nonparametric trend analyses revealed decreasing densities of adult fish (age 1+) in 19 sites (27%) and increases in 5 sites (7%). In contrast, juvenile fish (age 0) densities decreased in 4 sites (6%) and increased in 10 sites (14%). Declining adult brook trout trends were related to atmospheric warming rates during the study period, and this relationship was stronger than the effects of land use change or non-native brown trout. In contrast, juvenile fish trends generally increased with elevation but were not related to air temperature trends or land use change. Our analysis reveals significant changes in several brook trout populations over recent decades and implicates warming atmospheric conditions in population declines. Our findings also suggest the importance of temperature for adult survival rather than recruitment limitation in brook trout population dynamics.
Effect of Knife Use and Overlapping Gloves on Finger Temperature of Poultry Slaughterhouse Workers
Authors: Tirloni Adriana , Reis Diogo , Moro Antônio
Published: October 2024

Brazilian poultry slaughterhouses employ many workers, consequently exposing them to various ergonomic risks. This study aimed to analyze the effects of knife use and overlapping gloves on the finger temperatures of poultry slaughterhouse workers. Employees (n = 571) from seven Brazilian poultry slaughterhouses participated in this cross-sectional study. A Flir® T450SC infrared camera was used to record thermographic images of the workers’ hands. The workers were interviewed about work organization, cold thermal sensations, and the perception of upper-limb musculoskeletal discomfort. Dependent and independent sample t-tests and binary logistic regression models were applied. The results proved that the workers wore up to five overlapping gloves and had at least one finger with temperatures of ≤15 °C (46.6%) or ≤24 °C (98.1%). Workers that used a knife and wore a chainmail (CM) glove on their non-dominant hand had average finger temperatures significantly colder on the palmar surface than the anti-cut (AC) glove group (p = 0.029). The chance of one worker who wore a CM glove to have finger temperatures of ≤15 °C was 2.26 times greater than a worker who wore an AC glove. Those who wore an AC glove and those wearing a CM glove presented average overall finger temperatures significantly lower on the non-dominant hand (products) than the dominant hand (knife) (p < 0.001).
ChatGeoAI: Enabling Geospatial Analysis for Public through Natural Language, with Large Language Models
Authors: Mansourian Ali , Oucheikh Rachid
Published: October 2024

Large Language Models (LLMs) such as GPT, BART, and Gemini stand at the forefront of Generative Artificial Intelligence, showcasing remarkable prowess in natural language comprehension and task execution. This paper proposes a novel framework developed on the foundation of Llama 2, aiming to bridge the gap between natural language queries and executable code for geospatial analyses within the PyQGIS environment. It empowers non-expert users to leverage GIS technology without requiring deep knowledge of geospatial programming or tools. Through cutting-edge Natural Language Processing (NLP) techniques, including tailored entity recognition and ontology mapping, the framework accurately interprets user intents and translates them into specific GIS operations. Integration of geospatial ontologies enriches semantic comprehension, ensuring precise alignment between user descriptions, geospatial datasets, and geospatial analysis tasks. A code generation module empowered by Llama 2 converts these interpretations into PyQGIS scripts, enabling the execution of geospatial analysis and results visualization. Rigorous testing across a spectrum of geospatial analysis tasks, with incremental complexity, evaluates the framework and the performance of such a system, with LLM at its core. The proposed system demonstrates proficiency in handling various geometries, spatial relationships, and attribute queries, enabling accurate and efficient analysis of spatial datasets. Moreover, it offers robust error-handling mechanisms and supports tasks related to map styling, visualization, and data manipulation. However, it has some limitations, such as occasional struggles with ambiguous attribute names and aliases, which leads to potential inaccuracies in the filtering and retrieval of features. Despite these limitations, the system presents a promising solution for applications integrating LLMs into GIS and offers a flexible and user-friendly approach to geospatial analysis.