bluuebunny/crossref_metadata_2025 huggingface dataset:
DESIGN STRATEGY OF BATAK SOCIO-CULTURAL PARK AS A TOURIST DESTINATION WITH LOCAL WISDOM APRROACH IN LAKE TOBA REGION
Authors: Pasaribu Bernad Arifin , Suastika Made , Yuliani Sri
Published: April 2019

Indonesia is a country that has various ethnics and cultures. One of the tribes found in Indonesia is Batak tribe located in North Sumatra, Batak tribe can be divided into six sub-tribe of Batak Karo, Toba, Simalungun, Mandailinng, Angkola, Pakpak. In today's modern era, cultural degradation has caused the values of the nation being eroded so that these cultures need to be preserved to avoid them from extinction. This study describes the idea of accommodating activities that are preserving the culture of the Batak tribe as a Batak socio-cultural park. Not only accommodate, Batak socio-cultural park is also functioned as a tourist destination which will support the main function of preserving culture and introducing Batak culture to the wider community. The design method that will be applied is by applying the Batak’s local wisdom to the architecture of the Batak socio-cultural Park building to give a traditional impression and be able to be an attraction for tourists to come to visit. The results of the research are strategies to design a Batak socio-cultural park as a tourist destination by accommodating elements of local wisdom.
THE IMPACT OF LONG CANYON DESIGN AND WATERFRONT BARRIER BUILDINGS ON WIND VELOCITY IN A COASTAL AREA OF SELATPANJANG CITY
Authors: Rahman Boby , Dinapradipta Asri , Defiana Ima
Published: April 2019

The increase of waterfront buildings’ height has an effect on wind distribution in the urban canyon. On the other hand, the distribution of wind is needed in providing thermal balance in urban environments, especially in urban waterfront coastal areas. This study aimed at observing and analyzing the effect of building height (H) on waterfront buildings and aspects of the length to width (L/W) ratio related to the length of the canyon design. The observation was focused on the wind speed distribution. The research was an experimental research using ENVI-met V3.1 software for simulation. The results indicated that short canyon (low L/W value) results in lower wind speed changes compared to that of long one (higher L/W value) at all altitude levels. The short canyons provided more stability in wind speed reduction. The 15 meters wide of canyon design contributed to the highest average wind speed. Overall, the existence of a barrier building would result in a negative area of air flow and create a calm area within the distance of  ± 50 meters.
VEGETATION TYPOLOGY ON LAND USE IN SUPPORTING SURAKARTA CITY SUSTAINABLE DEVELOPMENT
Authors: Rini Erma Fitria , Putri Rufia Andisetyana , Nugraheni Dara Sinta
Published: April 2019

Green open spaces have natural elements and structures that carry out their ecological and aesthetical roles. The population density of Surakarta City is 11675 people/km2, which has an impact on the environment, such as the declining in urban air quality. Urban air quality can be overcome by providing sufficient vegetation. The availability of green open space in Surakarta City until 2014 only reached 12.4%, which means it has not been able to meet the minimum requirement of green open space, including vegetation in it. The method used in this study is descriptive analysis with primary data and satellite imagery. Vegetation studied is not only on public green open spaces, but also on the private green open spaces. The results show that the highest dominance of land use in Surakarta City is the trade and services. Unfortunately, this is inversely proportional to the existing average availability of vegetation cover in the domination, which only reaches 7%. This can be a recommendation for the government in prioritizing the development of green open spaces on those trade and services land use so it can support the sustainable development of Surakarta City.
PENGGUNAAN C&C LEARNING DALAM MENINGKATKAN KEMAMPUAN INTERAKSI DAN BERDAYA SAING POSITIF PADA KELAS READING
Authors: Rusdiyanti Irene Trisisca , Mafulah Siti
Published: April 2019

Abstrak

Kemampuan interaksi dan daya saing positif sangatlah dibutuhkan mahasiswa sebagai bekal menghadapi persaingan dunia kerja usai lulus dari perguruan tinggi, maka dari itu sebisa mungkin rasa itu harus dipupuk dan di tanamkan dalam diri masing-masing mahasiswa. Salah satunya adalah dengan pembelajaran yang mengandung kompetisi namun tetap berkooperasi dan kolaborasi yaitu C&C learning. Metode yang dipakai dalam penelitian ini adalah PTK dengan empat siklus yang diadopsi dari Kemmis & Taggart (1988) yang memiliki empat langkah: perencanaan tindakan, pelaksanaan tindakan, pengamatan, dan refleksi. Instrumen yang digunakan adalah lembar pengamatan, kuisioner dan tes. Hasil dari penelitian ini menyatakan bahwa pada siklus pertama hasil penelitian menunjukkan kurang berhasil karena hanya 46.15% mahasiswa memperoleh nilai dibawah 80. hal ini belum memenuhi kriteria keberhasilan yang telah ditetapkan. Sedangkan pada siklus kedua jumlah mahasiswa yang memperoleh nilai diatas 80 sebanyak 88.46%. Dengan perlehan ini maka penelitian disimpulkan telah sukses. Dari hasil kuisioner diperoleh respon dari mahasiswa sebagai berikut: sebanyak 24 mahasiswa (92,30 %) mahasiswa menyatakan senang dan mampu berinteraksi denagn baik. 25 mahasiswa (96,15%) menyatakan mampu menyatakan ide tanpa beban. Sehingga dapat disimpulkan bahwa C&C learning mmampu meningkatkan kemampuan interkasi dan berdaya saing positif dalam mata kuliah interpretive reading.

Kata kunci : C&C Learning, PTK, kemampuan kompetitif
The Ultrasound-guided Proximal Intercostal Block: Anatomical study and clinical correlation to analgesia for breast surgery
Authors: Zinbonyahgoon Nantthasorn , Luksanapruksa Panya , Piyaselakul Sitha , Pangthipampai Pawinee , Lohasammakul Suphalerk , Luansritisakul Choopong , Mali-ong Sunsanee , Sateantantikul Nawaporn , Chueaboonchai Theera , Vlassakov Kamen
Published: April 2019

Background:
The ultrasound-guided proximal intercostal block (PICB) is performed at the proximal intercostal space (ICS) between the internal intercostal membrane (IIM) and the endothoracic fascia/parietal pleura (EFPP) complex. Injectate spread may follow several routes and allow for multilevel trunk analgesia. The goal of this study was to examine the anatomical spread of large-volume PICB injections and its relevance to breast surgery analgesia.
Methods:
Fifteen two-level PICBs were performed in ten soft-embalmed cadavers. Radiographic contrast mixed with methylene blue was injected at the 2nd(15ml) and 4th(25ml) ICS, respectively. Fluoroscopy and dissection were performed to examine the injectate spread. Additionally, the medical records of 12 patients who had PICB for breast surgery were reviewed for documented dermatomal levels of clinical hypoesthesia. The records of twelve matched patients who had the same operations without PICB were reviewed to compare analgesia and opioid consumption.
Results:
Median contrast/dye spread was 4(2-8) and 3(2-5) vertebral segments by fluoroscopy and dissection respectively. Dissection revealed injectate spread to the adjacent paravertebral space, T3 (60%) and T5 (27%), and cranio-caudal spread along the endothoracic fascia (80%). Clinically, the median documented area of hypoesthesia was 5(4-7) dermatomes with 100% and 92% of the injections covering adjacent T3 and T5 dermatomes, respectively. The patients with PICB had significantly lower perioperative opioid consumption and trend towards lower pain scores.
Conclusions:
In this anatomical study, PICB at the 2nd and 4th ICS produced lateral spread along the corresponding intercostal space, medial spread to the adjacent paravertebral/epidural space and cranio-caudal spread along the endothoracic fascial plane. Clinically, combined PICBs at the same levels resulted in consistent segmental chest wall analgesia and reduction in perioperative opioid consumption after breast surgery. The incomplete overlap between paravertebral spread in the anatomical study and area of hypoesthesia in our clinical findings, suggests that additional non-paravertebral routes of injectate distribution, such as the endothoracic fascial plane, may play important clinical role in the multi-level coverage provided by this block technique.
Longitudinal observation of OCT imaging is a valuable tool to monitor primary vitreoretinal lymphoma treated with intravitreal injections of methotrexate
Authors: Zhao Huiying , Wang Xiaona , Mao Yu , Peng Xiaoyan
Published: April 2019

Background: Developing objective and repeatable indicators to evaluate the efficacy of PVRL treatment is important. The quantification of vitreous cells is a traditional criterion; however slight changes are difficult to ascertain. Spectral domain optical coherence tomography (SD-OCT) is objective, repeatable, and easily explained. The purpose of this study is to provide a longitudinal observation of OCT in PVRL treated with intravitreal injections of methotrexate (MTX) and to evaluate the utility of OCT in monitoringresponsiveness of PVRL to treatment. Methods: The medical records of patients with biopsy-positive PVRL attending our hospital between January 2016 and September 2017 who received intravitreal injections of MTX were included in this study. Pre- and posttreatment OCT images were reviewed independently by two researchers. Results: Of the 24 cases reviewed, 10 patients (18 eyes) were included. SD-OCT abnormalities at the initial visit included hyperreflective foci in the posterior vitreous (18/18), hyperreflective dots in the RPE (12/18), PEDs (detachment of retinal pigment epithelium) (9/18), hyperreflective band above the RPE (3/18), hyperreflectivity in the full thickness of the retina (8/18), and subretinal fluid (4/18). At one month after treatment, the subretinal fluid in cases with RD was absorbed, and subretinal fibrosis appeared. Other lesions were significantly reduced. At two months after treatment, the hyperreflective dots in the RPE, PEDs and subretinal fluid disappeared in 2 eyes, hyperreflectivity in the full thickness of the retina disappeared in 1 eye, and other abnormalities further improved. Additionally, retinal fibrosis was observed in 3 eyes. At nine months after treatment, all abnormalities observed at the first visit vanished. At the last visit, OCT showed subretinal fibrosis and in 3 eyes (16.7%), the disruption of outer retina in 9 eyes (50%) and thinning of the whole layer in 4 eyes (22.2%).Conclusions: Our observations reveal that characteristic OCT features in PVRL patients can reduce gradually and finally vanish with therapy. We propose that SD-OCT may be employed to monitor the responsiveness of PVRL to treatment, which may influence decision making in the management of this disease.
Meta-analysis of Corneal Biomechanical Effects after SMILE and FS-LASIK
Authors: Qin Jie , Fu Tingting , Tang Qi , Yang Lu , Chen Min
Published: April 2019

Background: To evaluate and compare corneal biomechanics after treatment of myopia using small-incision lenticule extraction (SMILE) and femtosecond laser-assisted in situ keratomileusis (FS-LASIK).
Methods: We performed a meta-analysis and searched for reports concerning corneal biomechanics after SMILE and FS-LASIK using MEDLINE, EMbase, CNKI and the Cochrane Library. The analysis included corneal hysteresis (CH) and corneal resistance factor (CRF) before and 3 months after the surgery. The quality of the reports was evaluated using the Newcastle-Ottawa scale (NOS). Statistical analysis was performed using RevMan5.
Results: Only six studies with a total of 771 eyes were ultimately included in this meta-analysis, and the random effects model was adopted. The preoperative and three-month postoperative CH and CRF of SMILE and FS-LASIK were compared by the meta-analysis. No statistically significant difference was found in CH or CRF between the SMILE group and the FS-LASIK group before the surgery (WMD，-0.12; 95% CI，-0.31～0.06; P，0.19; WMD，-0.05; 95% CI，-0.29～0.19; P，0.69). There was no statistically significant difference in CH between the two surgical methods 3 months after the operation in the foreign group (WMD，0.19; 95% CI，-1.02～1.41; P，0.75) or in the Chinese group (WMD，0.13; 95% CI，-0.16～0.41; P，0.75). Likewise, no statistically significant difference was found in CRF between the two surgical methods in the foreign group 3 months after the operation (WMD，-0.11; 95% CI，-2.53～-2.31; P，0.93). Nevertheless, the difference in CRF between the two surgical methods was statistically significant in the Chinese group (WMD，0.26; 95% CI，0.06～0.47; P，0.01).
Concusion: This meta-analysis indicated that SMILE showed no significant postoperative advantage in CH in comparison with FS-LASIK. For CRF, SMILE exhibited no obvious postoperative advantage in comparison with FS-LASIK in the foreign group, whereas SMILE was superior to FS-LASIK in the Chinese group.
GALC mutations in Chinese patients with late-onset Krabbe disease: a case report
Authors: Zhuang Shunzhi , Kong Lingen , Li Caiming , Chen Likun , Zhang Tingting
Published: April 2019

Background: Krabbe disease (also known as globoid cell leukodystrophy) is an autosomal recessive neurodegenerative disorder caused by a deficiency of the enzyme -galactocerebrosidase (galactosylceramidase, GALC). The deficiency of GALC leads to accumulation of galactosylceramide and psychosine, the latter GALC substrate having a potential role in triggering demyelination. Typically, the disease has an infantile onset, with rapid deterioration in the first few months, leading to death before the age of 2 years. The late onset forms (late-infantile, juvenile, and adult forms) are rare with variable clinical outcomes, presenting spastic paraplegia as the main symptom.
Case presentation: We recruited a family with two affected individuals. The proband (Patient 1), a 25-year-old male, was presented with slow progressive spastic gait disturbance and vision loss, suffering since the 5th year of life. His elder sister (Patient 2), became wheelchair-bound and demented at the age of 22 years. Brain magnetic resonance imaging (MRI) showed increased signal intensity in the white matter along with the involvement of the bilateral corticospinal tracts. GALC deficiency was confirmed by biochemical analysis. DNA sequencing revealed two mutations (c.865G>C: p. G289R and c.136G>T: p. D46Y) in GALC. The clinical characteristics, brain MRI, biochemical and molecular findings led to the diagnosis of Krabbe disease.
Conclusion: Clinical and neuroimaged signs, positive enzymatic analysis and molecular data converged to definite diagnosis in this neurodegenerative disease.
Miller Fisher Syndrome presenting as unilateral abducens nerve palsy: A case report
Authors: Silva Neomal Sawanawadu Dilantha De , Singhapathirana Suranga , Silva Chintaka Eshan De
Published: April 2019

Background : Miller Fisher Syndrome usually presents with complete ophthalmoplegia, areflexia and ataxia. We present an unusual case which presented with unilateral abducens nerve palsy. Case presentation : A 51 year old female patient presented with a history of difficulty in walking and double vision for 1 week which started 2 weeks following an episode of acute gastroenteritis. She didn’t have any bladder bowel incontinence or difficulty in breathing. On examination there was left side abducens nerve palsy and bilateral significant dysmetria. Upper limb and lower limb power was 4/5 with global areflexia. There was no fatigability or sensory deficit. Higher cortical functions were intact with Glasgow Coma Scale of 15/15. Brain stem cerebro vascular accident, alcohol, toxin or drug mediated disease, myasthenia gravis, Bickerstaff encephalitis and Miller-Fisher syndrome were considered as possible differential diagnosis. There was no history of alcohol consumption or any exposure to drugs or toxins. Her Non contrast brain and MRI brain were normal. Nerve conduction study showed asymmetrical sensory motor and F wave abnormalities consistent with a Guillen-Barre Sydrome variant. Cerebro Spinal Fluid analysis showed albumino-cytological dissociation. These findings suggested the diagnosis of Miller-Fisher Syndrome. She was started on plasmaphareis. Her vital parameters, vital capacity and neurological deficit were closely monitored. With 5 cycles of plasmapharesis she made a complete neurological recovery and she was discharged on 16th day of admission. Conclusion: Miller Fisher Syndrome can present as unilateral abducens nerve palsy and early diagnosis and treatment leads to excellent functional outcome.
POSTERIOR C1-C2 FUSION FOR ATLANTOAXIAL ROTATORY FIXATION AFTER POSTERIOR FOSSA CRANIOTOMY IN A 4-YEAR-OLD: A CASE REPORT
Authors: Benites Vinicius Meldau , Cavalheiro Sergio
Published: April 2019

Study Design: Case report Objective: This study aimed to highlight that Atlantoaxial rotatory fixation (AARF) can be related to neurosurgery procedures in children with an afterwards demonstration of good results after halo-gravity traction and C1-C2 stabilization using the Harms technique. Summary of Background Data: AARF is characterized by dislocation or subluxation of the atlantoaxial joint, leading to a rotational deformity which may cause pain. Such a condition is mostly found in pediatric patients. Trauma, upper respiratory infections, surgery of the head and the neck, and even rheumatoid arthritis and Down syndrome have been designated as predisposing factors. It is important to note that in some cases AARF evolves with no apparent cause and to date, the choice of optimal surgical procedure should be carefully selected, considering the anatomical and bone conditions, as well as the surgeon’s experience with each technique. Methods: We report the first case related, in our knowledge, of a 4-year-old boy who presented atlantoaxial rotatory fixation after a posterior fossa craniotomy to treat a cerebellar astrocytoma. Results: At our medical facility, we diagnosed AARF by plain radiograph and CT image, and he was treated with continuous cranial traction for 14 days. Initially, we detected that he had no C1 posterior arch or C2 spinous process, so our choice was to perform Harms technique. Postoperatively, the patient was placed in a cervical collar for four weeks. At him 4-years postoperative follow-up, he was doing well and did not develop any complication. Conclusion: We call the attention to the fact of AARF can be developed after neurosurgical procedures. A surgical technique to be used in Atlantoaxial subluxation should be carefully select. In our case, Harms technique after cranial traction was an excellent option to correct and stabilize the abnormal neck position presented. However, further studies are required to determine the best technique to be used in the pediatric population.
The IPO initial returns-aftermarket risk question revisited: evidence from firms in Taiwan
Authors: Shen Fong-Yi , Goo Yeong-Jia
Published: April 2019

The purpose of this study is to utilize the Three Stage Least Squares (3SLS) of the simultaneous equation estimation approach to revisit the possible cross relationship between IPO initial returns and aftermarket risk. A structural form equation system of IPO initial returns and aftermarket risk equations is estimated first to obtain the structural form coefficients. The analytically derived reduced form coefficients are then calculated to analyze the net effects of each exogenous variable on two endogenous variables. Major findings of this study are as follows. First, the signs of net effects of all exogenous variables on IPO initial returns and aftermarket risk are the same. In other words, any change in exogenous variables, IPO initial returns and IPO aftermarket risk will change in the same direction, i.e., the higher (lower) the IPO initial returns, the higher (lower) the IPO aftermarket risk. Second, the less the degree of corporate governance, the higher the IPO initial returns and aftermarket risk. Third, the higher the market risk or return before IPO, the higher the IPO initial returns and aftermarket risk.
Rainfall analysis for rain-fed farming in the Great Rift Valley Basins of Ethiopia
Authors: Ademe Fitih , Kibret Kibebew , Beyene Sheleme , Getinet Mezgebu , Mitike Gashaw
Published: April 2019

Rainfall is the most important source of water for crop production in Ethiopia. However, its temporal and spatial variability is leading to serious food shortages and insecurity in the country. This study was aimed at investigating the characteristics of selected agroclimatic variables over the great Rift Valley regions of Ethiopia. Long term (1981–2010) climate data were analyzed for 17 stations selected based on agroecology representation. Selected descriptors for climate variability and the Mann–Kendall trend test were employed. Onset, cessation, length of growing period (LGP), water requirement satisfaction index and dry spell occurrence during the growing period were determined. The results showed low to very high rainfall variability (14–35%), LGP (20–256 days) and dry spell probability (50–100%) during the main season. Significant (P ≤ 0.05) annual and seasonal rainfall trends were observed in some stations. The probability of occurrence of a dry spell during the seasons was found to be a challenge for most of the stations in the mid and low altitude areas of the basins. Consequently, seasonal water deficit was observed in these areas which hampered crop production. Area specific recommendations are thus required based on specific challenges in the study region.
Assessing the effects of intra-granule precipitation in a full-scale industrial anaerobic digester
Authors: Feldman H. , Flores-Alsina X. , Ramin P. , Kjellberg K. , Jeppsson U. , Batstone D. J. , Gernaey K. V.
Published: April 2019

In this paper, a multi-scale model is used to assess the multiple mineral precipitation potential in a full-scale anaerobic granular sludge system. Reactor behaviour is analysed under different operational conditions (addition/no addition of reject water from dewatering of lime-stabilized biomass) and periods of time (short/long term). Model predictions suggest that a higher contribution of reject water promotes the risk of intra-granule CaCO3 formation as a result of the increased quantity of calcium arriving with that stream combined with strong pH gradients within the biofilm. The distribution of these precipitates depends on: (i) reactor height; and (ii) granule size. The study also exposes the potential undesirable effects of the long-term addition of reject water (a decrease in energy recovery of 20% over a 100-day period), caused by loss in biomass activity (due to microbial displacement), and the reduced buffer capacity. This demonstrates how both short-term and long-term operational conditions may affect the formation of precipitates within anaerobic granules, and how it may influence methane production and consequently energy recovery.
Innovación y Tecnología para el Agro-Ecuatoriano
Authors: Sosa del Castillo Daynet
Published: April 2019

El sector agrícola del país requiere de grandes cambios, de una nueva visión, que le permita enfrentar los desafíos actuales de la región y del mundo, incorporando estrategias en las que la innovación, las nuevas tecnologías y, sobre todo, la sinergia indispensable entre la academia y los productores ecuatorianos, sean fundamentales.

Ecuador, como el resto de los países que tienen Acuerdos de Libre Comercio, necesitan aumentar la productividad de la agricultura en tiempos de cambio climático, de una manera sostenible, a fin de lograr un desarrollo competitivo que sea compatible con la conservación y el manejo adecuado de los recursos naturales, y sobre todo, con la reducción del hambre y de la pobreza, especialmente en zonas rurales.
Evaluación del almidón de papa (Solanum tuberosum) en la obtención de bioplástico
Authors: Acosta J , Gomajoa H , Benavides Y , Charfuelan A , Valenzuela F
Published: April 2019

Los bioplásticos a partir de almidón, son productos innovadores con un gran potencial de desarrollo y altamente amigables con el medio ambiente; en tal sentido, se evaluó el almidón extraído de cinco variedades de papa categoría richi (Superior (S), ICA Capiro (IC), Betina (B), Parda Pastusa (PP) y Criolla (C)) para la obtención de bioplásticos. Para lo anterior, se extrajo el almidón por el método de decantación natural, se determinó sus propiedades fisicoquímicas como temperatura de gelatinización (Tg), índice de absorbancia (IA), índice de solubilidad (IS), poder de hinchamiento (PDH), proteína, amilosa y amilopectina teniendo en cuenta la norma ISO 6647. Los resultados de cada variedad se evaluaron con una matriz de priorización, posteriormente, se elaboró el bioplástico siguiendo la metodología realizada por (Meza, 2016) y validado con un diseño unifactorial, donde se evalúa la incidencia del porcentaje de almidón (3, 6, 8%) en la mezcla, como variables de respuesta resistencia y calibre con 2 réplicas. Los resultados indican que la variedad (B) tiene las mejores características con 64,125 °C para Tg, para IA 3.130 g gel/g, IS 18,75 g/ml, PDH 4.03, proteína 0.341 %, amilosa 20,751 mg/L y amilopectina 79,249 mg/L. El bioplástico obtenido de esta variedad presentó características de resistencia de 25.35 MPa y calibre 0.17 mm obteniendo las mejores características mecánicas del bioplástico. Se concluye que el almidón de papa de categoría richi tiene alta potencialidad para la generación de bioplástico.
Phosphorylation Analysis of the starch synthase IV-Arabidopsis thaliana SSIV-CR region
Authors: Calderón Cristina , Mérida Ángel
Published: April 2019

Starch synthase (SSIV) plays a specific role in starch synthesis. Previous evidence in our laboratory has shown that SSIV forms dimers, which depends on a region located between the extended coiled-coil region and the glucosyltransferase domain of SSIV. This region is highly conserved between all SSIV enzymes sequenced to date. In this work, we have analyzed the potential phosphorylation of two amino acid residues of the protein (tyrosine 515 and serine 459) and its possible role in the dimerization and activity of SSIV. We have obtained mutated versions of the AtSSIV polypeptide where the amino acid Tyr 515 has been changed to Phe or Glu residue and Ser 459 has been changed to Ala or Asp. We show that the phosphorylation of the Tyr 515 would prevent the formation of a dimer and hence the interaction with FBN1b and suggest that the change of the Tyr 515 residue by a Phe does not affect to the formation of a dimer but reduces the enzymatic activity of the protein considerably. A similar decrease was observed when the amino acid was changed to a Glu residue, suggesting that Tyr 515 residue is necessary for the AtSSIV activity.
Extracción de Carotenos de Cáscara de Mango (Mangifera indica) con mezclas de Solventes y Extracción Asistida
Authors: Calderón Sara , Vera Edwin
Published: April 2019

The extraction of carotenoids with lyophilized peel of three varieties of mango was carried out as matrix: Tommy Atkins, Haden and Kent. The following physical and chemical characteristics were evaluated: color, humidity, soluble solids, pH, and water retention capacity (CRA). The Tommy Atkins variety presented the highest values of moisture, pH, soluble solids, and (CRA), while the Haden variety stands out in the content of ashes and total carotenes. It was used for the extraction of carotenes mixtures of hexane: heptane: ethanol in different concentrations where heptane was the solvent with the highest extraction performance of carotenes, with 27.24 % with regard to the method assisted by ultrasound. For the enzymatic treatment, we worked at a temperature of 35 °C, with two enzymatic cocktails with constant agitation for 30 and 60 min. The GRANOZYME PTE 100 enzyme complex had an extraction yield equal to 60.12 %. The ultrasound-assisted extraction (UAE) was performed in an ultrasonic processor for 10, 15 and 30 min at a power of 750 W, frequency of 20 kHz and a duty cycle of 60 % at room temperature. After 30 min, the highest extraction yields were obtained. The Haden variety is an interesting source of carotenes.
Sedative and anxiolytic effect of the methanolic extract of Erythrina edulis Triana ex Micheli in mice
Authors: Sarmiento Josué , Saa Mariana , Peñaherrera Eugenia
Published: April 2019

The traditional use of medicinal plants and its link with pharmacological studies is essential in order to corroborate the effect scientifically. The present work was an experimental study designed to investigate the sedative and anxiolytic effect of the methanol extract of the leaves of Erythrina edulis. The extract was prepared by percolation. Different concentrations: 500, 250 and 125 mg/kg of the extract and diazepam as a controlled drug were administered intraperitoneally to Swiss CD1 mice for both, sedation and anxiety tests. The sleep enhancement test with pentobarbital and the traction test were used for the sedative activity. Results showed that the extract did not possess sedative activity in any of the administered doses. However, the possibility of an opposite effect was observed as an activation of the central nervous system probably. The anxiolytic activity was evaluated by the open field test and the elevated plus maze test, where a behavior with a low level of anxiety was observed. Altogether, the results suggest that the extract has an anxiolytic activity without sedation, which supports traditional use. But, its responses are not dose-dependent, and its mechanism of action is unknown.

Besides, toxicity assay was performed in Artemia salina nauplii, resulting in a lethal concentration 50 of 16.570 ug/mL corresponding to zero toxicity. Finally, the phytochemical analysis of the extract revealed the presence of flavonoids (flavonols, flavones and phenolic carboxylic acids), anthrones, anthranols, terpenes (mono and sesquiterpenes), saponins and hydrolysable tannins.
Barriers and Enablers Affecting Successful Implementation of the Electronic Health Service Sisom: Multicenter Study of Child Participation in Pediatric Care (Preprint)
Authors: Svedberg Petra , Arvidsson Susann , Larsson Ingrid , Carlsson Ing-Marie , Nygren Jens M
Published: April 2019

BACKGROUND

Children’s participation in health care is one of the most important components in the management of their disease. Electronic health (eHealth) services that are adapted to the needs of children have the potential for restructuring how children and professionals work together. Therefore, a digital interactive assessment and communication tool, Sisom, was developed to give children aged between 6 and 12 years a voice in their own health care. However, the implementation of eHealth services such as Sisom in daily practice in pediatric health care is rarely investigated.

OBJECTIVE

The aim of this study was to explore the process of implementing Sisom for children in pediatric care in Sweden. More specifically, the study aimed to (1) evaluate whether the implementation strategy was conducted as planned, (2) understand the barriers and facilitators of the implementation strategy in pediatric care settings, (3) gain insight into how professionals work with the specific intervention, and (4) gain insight into the usefulness and effects of the intervention from the professionals’ perspectives.

METHODS

A process evaluation design was used to study the implementation of Sisom at 4 pediatric care centers in Sweden. An extensive amount of qualitative and quantitative data was collected before, during, and after the intervention through self-report checklists, memos, and interviews with professionals. In total, 46 children, aged between 6 and 13 years, participated. The children used Sisom on two occasions during 6 months. When they used Sisom, a printed report formed the basis for a forthcoming dialogue between professionals, children, and their parents.

RESULTS

To our knowledge, this is the first implementation study of an eHealth communication tool aimed at strengthening children’s participation in pediatric health care. Key factors for successful implementation were alignment of the solution with the values and goals of the organization, health care professionals’ beliefs in the usefulness and usability of the solution, and health care professionals’ willingness to change their professional roles guided by the solution.

CONCLUSIONS

The results from the study show that it is possible to restructure health care delivery toward a child-centered approach, if there is a willingness and preparedness in the organization to implement an eHealth solution with the aim of restructuring the way of working with children’s participation.
Integrating Health Technologies in Health Services for Syrian Refugees in Lebanon: Qualitative Study (Preprint)
Authors: Talhouk Reem , Akik Chaza , Araujo-Soares Vera , Ahmad Balsam , Mesmar Sandra , Olivier Patrick , Balaam Madeline , Montague Kyle , Garbett Andrew , Ghattas Hala
Published: April 2019

BACKGROUND

Lebanon currently hosts around one million Syrian refugees. There has been an increasing interest in integrating eHealth and mHealth technologies into the provision of primary health care to refugees and Lebanese citizens.

OBJECTIVE

We aimed to gain a deeper understanding of the potential for technology integration in primary health care provision in the context of the protracted Syrian refugee crisis in Lebanon.

METHODS

A total of 17 face-to-face semistructured interviews were conducted with key informants (n=8) and health care providers (n=9) involved in the provision of health care to the Syrian refugee population in Lebanon. Interviews were audio recorded and directly translated and transcribed from Arabic to English. Thematic analysis was conducted.

RESULTS

Study participants indicated that varying resources, primarily time and the availability of technologies at primary health care centers, were the main challenges for integrating technologies for the provision of health care services for refugees. This challenge is compounded by refugees being viewed by participants as a mobile population thus making primary health care centers less willing to invest in refugee health technologies. Lastly, participant views regarding the health and technology literacies of refugees varied and that was considered to be a challenge that needs to be addressed for the successful integration of refugee health technologies.

CONCLUSIONS

Our findings indicate that in the context of integrating technology into the provision of health care for refugees in a low or middle income country such as Lebanon, some barriers for technology integration related to the availability of resources are similar to those found elsewhere. However, we identified participant views of refugees’ health and technology literacies to be a challenge specific to the context of this refugee crisis. These challenges need to be addressed when considering refugee health technologies. This could be done by increasing the visibility of refugee capabilities and configuring refugee health technologies so that they may create spaces in which refugees are empowered within the health care system and can work toward debunking the views discovered in this study.
A Research Roadmap: Connected Health as an Enabler of Cancer Patient Support (Preprint)
Authors: Signorelli Gabriel Ruiz , Lehocki Fedor , Mora Fernández Matilde , O'Neill Gillian , O'Connor Dominic , Brennan Louise , Monteiro-Guerra Francisco , Rivero-Rodriguez Alejandro , Hors-Fraile Santiago , Munoz-Penas Juan , Bonjorn Dalmau Mercè , Mota Jorge , Oliveira Ricardo B , Mrinakova Bela , Putekova Silvia , Muro Naiara , Zambrana Francisco , Garcia-Gomez Juan M
Published: April 2019

UNSTRUCTURED

The evidence that quality of life is a positive variable for survival of cancer patients has prompted the interest of the health and pharmaceutical industry in considering that variable as a final clinical outcome. Sustained improvements in cancer care in recent years have resulted in increased numbers of people living with and beyond cancer, with increased attention being placed on improving quality of life for those individuals. Connected Health provides the foundations for the transformation of cancer care into a patient-centric model, focused on providing fully connected, personalized support and therapy for the unique needs of each patient.
Connected Health creates an opportunity to overcome barriers to health care support among patients diagnosed with chronic conditions. This paper provides an overview of important areas for the foundations of the creation of a new Connected Health paradigm in cancer care. Here we discuss the capabilities of mobile and wearable technologies; we also discuss pervasive and persuasive strategies and device systems to provide multidisciplinary and inclusive approaches for cancer patients for mental well-being, physical activity promotion, and rehabilitation.
Several examples already show that there is enthusiasm in strengthening the possibilities offered by Connected Health in persuasive and pervasive technology in cancer care. Developments harnessing the Internet of Things, personalization, patient-centered design, and artificial intelligence help to monitor and assess the health status of cancer patients. Furthermore, this paper analyses the data infrastructure ecosystem for Connected Health and its semantic interoperability with the Connected Health economy ecosystem and its associated barriers. Interoperability is essential when developing Connected Health solutions that integrate with health systems and electronic health records.
Given the exponential business growth of the Connected Health economy, there is an urgent need to develop mHealth exponentially, making it both an attractive and challenging market. In conclusion, there is a need for user-centered and multidisciplinary standards of practice to the design, development, evaluation, and implementation of Connected Health interventions in cancer care to ensure their acceptability, practicality, feasibility, effectiveness, affordability, safety, and equity.
A STUDY ON GROSS SLIP AND FRETTING WEAR OF CONTACTS INVOLVING A POWER-LAW GRADED ELASTIC HALF-SPACE
Authors: Hess Markus
Published: April 2019

For the steady wear state of two contact problems involving power-law graded materials, closed-form solutions are derived in terms of pressure distribution and limiting shapes of profile. Both gross slip of an initially flat-ended cylindrical punch on a power-law graded half-space and the load-controlled fretting wear under partial slip of an initially parabolic indenter are studied. In the case of gross slip at fixed penetration depth there exists a certain exponent of elastic inhomogeneity, for which the effective volume change takes its maximum value. To minimize wear due to fretting under partial slip, an amplitude dependent design of the material gradient is necessary. For large amplitudes of the tangential force a gradient ranged from a soft surface to a hard ground is beneficial, small amplitudes require a reverse gradient characterized by a hard surface and a soft ground. However, the choice of the material gradient also has a decisive influence on the strength of stress singularities at the contact edge and thus the initiation of fretting fatigue cracks, which is why it is discussed in more detail.
Self-determination Affects the Use of Self-presentation Strategies On Social Networking Sites
Authors: Cheng Zhichao , Pan Yang , Ni Yuan
Published: April 2019

We examined how orientation of self-determination affects the use of online self-presentation strategies among social networking site users. Participants were 374 young adult WeChat users (age range = 18–22 years; 166 men, 208 women) who completed the self-report measures of the
General Causality Orientations Scale and the Online Interpersonal Communication Strategies Scale. The results indicated that an autonomy orientation of self-determination was positively related to the use of automatic ingratiation strategies; a controlled orientation of self-determination
was the most active motivational orientation and was related to the use of the online self-presentation strategies of ingratiation, self-promotion, exemplification, and supplication; and an impersonal orientation of self-determination was primarily associated with use of the supplication strategy
of self-presentation. These novel insights regarding self-determination could help to explain individual differences in online self-presentation.
FREEDOM, LOW AND IMAGINATION THE LECTURES OF F.W.J. SCHELLING IN 1800-1810s
Authors: Rezvykh P V
Published: April 2019

The gives the detailed analysis of the ratio of freedom and imagination in an unpublished manuscript written by F.V.Y. Schelling, which contains the materials for the lecture course read at Erlangen University in 1820-1821. The author focuses on the question of imagination as a condition for the possibility to unfold the modal differences that provide the hierarchy of predicative definitions. The article shows that both the draft philosophy of mythology and the philosophy of revelation are a direct continuation of the transcendentalist program given by Kant.Those projects bases on the thesis that the consciousness of freedom and consciousness of the law, justified in the “Critique of Practical Reason”, are related one another. Schelling following Kant’s theory, points to the law and to the unconditional imperative of freedom as the main principle which is not only theoretical or practical, but determines the separation of ontological and deontological modalities. At the same time, the formal structure of an imperative as a command has the specific character of “hiden opening”: what is themed in an imperative is not opened as a meaningful opportunity, it is only opened as theopportunity in its difference from necessity. I show in this article that interpreting the Schelling possibility relies on the teachings of I. Kant in his transcendental idealconception, connected with Kant's interpretation of the imagination’s productive ability. In the middle of Schelling’s theological interpretation of Kant's consciousness of lawdoctrine as the “fact of mind” lies the analogy between peacemaking and the ancestral sin of the first people. This concept is the main source of the theory of potency as ontological modalities, developed by Schelling in the 1830s - 1840s in lectures on the philosophy of mythology and the philosophy of revelation.
Histórias Interativas para a Disciplina de História no Ensino Médio: Uma Abordagem de Autoria Compartilhada
Authors: Peixoto Marques Marcelo , Zanki Cordenonsi Andre
Published: April 2019

O presente estudo apresenta uma proposta de utilização de novas tecnologias educacionais como alternativa capaz de contribuir positivamente no processo de ensino de História. Assim sendo, buscou-se analisar a produção de um jogo de histórias interativas, por meio da utilização dos softwares Twine e Storybird em uma escola pública de ensino médio, no município de Restinga Sêca. Este estudo teve caráter qualitativo, nesse sentido utilizou-se como metodologia o estudo de caso, visando analisar o comportamento de alunos e professores e o direcionamento do processo de ensino e aprendizagem mediado pelas tecnologias. Ficou evidenciado nessa pesquisa o fomento de novas possibilidades de interação no cenário educacional, por meio de uma abordagem capaz de aproximar os conteúdos programáticos da disciplina de História, com novas ferramentas tecnológicas capazes de ressignificar a relação da disciplina com os alunos.
Produção de vídeos na perspectiva da aprendizagem multimídia
Authors: Eduardo Orozco Contreras Patrício , Machado Ellensohn Ricardo , Smaniotto Barin Claudia
Published: April 2019

O presente trabalho analisa e discute as potencialidades, desafios de produção e características de design do vídeo como fonte de informação e referência para os estudantes do Curso de Música e Tecnologia da UFSM. O trabalho consiste num estudo descritivo qualitativo de cunho crítico-reflexivo acerca de um relato de experiência a partir de uma prática já existente na disciplina complementar de graduação: Áudio Digital Multipista I, II, II e IV, revista, analisada e comparada com o modelo de Clark e Mayer de Instrucional Design. Com base nos resultados obtidos nessa experiência sustentamos a tese de que a produção de vídeos considerando os princípios do Design Instrucional é viável e impacta na qualidade educacional do material produzido uma vez que gerencia a carga cognitiva.
Realidade Aumentada em Geografia: uma atividade de orientação no ensino fundamental
Authors: Herpich Fabrício , Becker Nunes Felipe , Bierhalz Voss Gleizer , Sindeaux Paulo , Margarida Rockenbach Tarouco Liane , Valdeni De Lima José
Published: April 2019

Este artigo tem como objetivo apresentar uma atividade de orientaçãopara auxiliar no processo de ensino-aprendizagem de Geografia através do uso de realidade aumentada (RA). Para tanto, foi conduzida uma pesquisa nãoexperimental com estudantes do 6º ano do ensino fundamental de umainstituição de ensino pública. Os resultados alcançados evidenciaram que osparticipantes consideraram a abordagem positiva e que a estratégia utilizadacom a atividade de orientação, combinada com o uso de acessóriostecnológicos, não só colaborou com a visualização do conteúdo como também permitiu estabelecer a relação entre teoria e prática.
RECONSTRUINDO A COMPREENSÃO DE PRÁTICA PEDAGÓGICA: UMA ANÁLISE SOBRE A APRENDIZAGEM DE ALGORITMOS
Authors: Py Tortelli Noronha Fabrícia , Backes Luciana , Antonio Casagrande Cledes
Published: April 2019

Este artigo discute a prática pedagógica para a construção do conhecimento de algoritmos. O estudo foi de natureza exploratória qualitativa, do tipo Estudo de Caso. Mediante questionário e diário de campo foram extraídos os dados e, posteriormente, submetidos à Técnica de Análise de Conteúdo. Evidenciamos que a prática pedagógica, intencional e problematizadora, pautada na ação dos educandos, possibilitou a contextualização do conhecimento por meio das tecnologias, assegurando a visão mais ampla do processo de aprendizagem. Logo, a reestruturação da prática pedagógica sucedeu-se nas ações e interações dos educandos, em autoria com o professor e em coautoria com a ação dos colegas. Destacamos pontos de complexidade: rompimento da compreensão tradicional de ensino, dificuldade em legitimar o colega, tempo de aprendizagem e atuação em conjunto.
Mobile learning use in the classroom: approaches to the teaching and learning process
Authors: De Souza Santana Neri , Tojeiro Giordani Annecy , Dos Santos Rosa Selma , Coelho Neto João
Published: April 2019

Considering how Mobile Digital Technologies can assist in the teaching andlearning process, in the most diverse areas of Teaching. This paper results from a Systematic Literature Review on the use of Mobile Learning in teaching and learning. Thereby, we identified its central characteristics, which refers to the use of mobile devices, and mapped out areas of Education and Teaching that have been using the MLearning in their educational activities in school scope. The methodological referral used was the Systematic Literature Review, over a period of 10 years, from 2007 to 2017, on the Theses and Dissertations Bank from Coordination for the Improvement of Higher Education Personnel (CAPES), on Capes Periodic Bank and in the periodic listed in the restricted index (A1, A2 and B1) in the Teaching area of the WebQualis platform - Quadrennial Periodic Classifications 2013-2016. The results are an even small number of effective use of Mobile Learning in school scope, although there is evidence that its using is feasible in classrooms due to its characteristics of working with portable and simple devices, commonly used by students in personal life, not implying in additional costs.