Major Depressive Disorder
Authors: Grobler G 
Published: June 2017

The treatment guideline draws on several international guidelines: (<div style="left: 477.479px; top: 324.52px; font-size: 15.45px; font-family: serif;">i</div><div style="left: 481.424px; top: 324.72px; font-size: 15.45px; font-family: serif; transform: scaleX(0.955);" data-canvas-width="8.595">)</div><div style="left: 70.8662px; top: 344.72px; font-size: 15.45px; font-family: serif; transform: scaleX(1.00294);" data-canvas-width="422.63399999999984">Practice Guidelines of the American Psychiatric Association (APA)</div><div style="left: 70.8662px; top: 364.72px; font-size: 15.45px; font-family: serif; transform: scaleX(0.962449);" data-canvas-width="420.28950000000003">for the Treatment of Patients with Major Depressive Disorder, Second</div><div style="left: 70.8662px; top: 384.72px; font-size: 15.45px; font-family: serif; transform: scaleX(0.945309);" data-canvas-width="47.068499999999986">Edition;</div><div style="left: 117.785px; top: 385.947px; font-size: 9.00733px; font-family: serif; transform: scaleX(0.974443);" data-canvas-width="10.231649999999998">[1]</div><div style="left: 128.017px; top: 384.72px; font-size: 15.45px; font-family: serif; transform: scaleX(1.42167);" data-canvas-width="12.794999999999998">(</div><div style="left: 140.663px; top: 384.52px; font-size: 15.45px; font-family: serif; transform: scaleX(0.913981);" data-canvas-width="7.844999999999999">ii</div><div style="left: 148.358px; top: 384.72px; font-size: 15.45px; font-family: serif; transform: scaleX(1.03879);" data-canvas-width="346.0034999999999">) Clinical Guidelines for the Treatment of Depressive</div><div style="left: 70.8662px; top: 404.72px; font-size: 15.45px; font-family: serif; transform: scaleX(0.982156);" data-canvas-width="420.8129999999999">Disorders by the Canadian Psychiatric Association and the Canadian</div><div style="left: 70.8662px; top: 424.72px; font-size: 15.45px; font-family: serif; transform: scaleX(1.06015);" data-canvas-width="374.1000000000001">Network for Mood and Anxiety Treatments (CANMAT);</div><div style="left: 445.018px; top: 425.947px; font-size: 9.00733px; font-family: serif; transform: scaleX(0.996097);" data-canvas-width="10.45902">[2]</div><div style="left: 455.592px; top: 424.72px; font-size: 15.45px; font-family: serif; transform: scaleX(1.52833);" data-canvas-width="13.754999999999999">(</div><div style="left: 469.386px; top: 424.52px; font-size: 15.45px; font-family: serif; transform: scaleX(0.930874);" data-canvas-width="11.985">iii</div><div style="left: 481.424px; top: 424.72px; font-size: 15.45px; font-family: serif; transform: scaleX(0.955);" data-canvas-width="8.595">)</div><div style="left: 70.8662px; top: 444.72px; font-size: 15.45px; font-family: serif; transform: scaleX(0.92219);" data-canvas-width="346.4745">National Institute for Clinical Excellence (NICE) guidelines;</div><div style="left: 417.194px; top: 445.947px; font-size: 9.00733px; font-family: serif; transform: scaleX(0.974443);" data-canvas-width="10.231649999999998">[3]</div><div style="left: 427.426px; top: 444.72px; font-size: 15.45px; font-family: serif; transform: scaleX(0.8725);" data-canvas-width="7.852499999999999">(</div><div style="left: 435.128px; top: 444.52px; font-size: 15.45px; font-family: serif; transform: scaleX(0.867244);" data-canvas-width="10.425">iv</div><div style="left: 445.402px; top: 444.72px; font-size: 15.45px; font-family: serif; transform: scaleX(0.885045);" data-canvas-width="44.031">) Royal</div><div style="left: 70.8662px; top: 464.72px; font-size: 15.45px; font-family: serif; transform: scaleX(0.960345);" data-canvas-width="420.4709999999999">Australian and New Zealand College of Psychiatrists Clinical Practice</div><div style="left: 70.8662px; top: 484.72px; font-size: 15.45px; font-family: serif; transform: scaleX(0.952181);" data-canvas-width="276.6284999999999">Guidelines Team for Depression (RANZCAP);</div><div style="left: 347.341px; top: 485.947px; font-size: 9.00733px; font-family: serif; transform: scaleX(0.974443);" data-canvas-width="10.231649999999998">[4]</div><div style="left: 357.572px; top: 484.72px; font-size: 15.45px; font-family: serif; transform: scaleX(1.05167);" data-canvas-width="9.465">(</div><div style="left: 366.887px; top: 484.52px; font-size: 15.45px; font-family: serif;">v</div><div style="left: 373.442px; top: 484.72px; font-size: 15.45px; font-family: serif; transform: scaleX(0.95722);" data-canvas-width="117.59850000000002">) Texas Medication</div><div style="left: 70.8662px; top: 504.72px; font-size: 15.45px; font-family: serif; transform: scaleX(0.99545);" data-canvas-width="242.95199999999997">Algorithm Project (TMAP) Guidelines;</div><div style="left: 313.679px; top: 505.947px; font-size: 9.00733px; font-family: serif; transform: scaleX(0.974443);" data-canvas-width="10.231649999999998">[5]</div><div style="left: 323.91px; top: 504.72px; font-size: 15.45px; font-family: serif; transform: scaleX(1.41);" data-canvas-width="12.69">(</div><div style="left: 336.454px; top: 504.52px; font-size: 15.45px; font-family: serif; transform: scaleX(0.902184);" data-canvas-width="10.845">vi</div><div style="left: 347.149px; top: 504.72px; font-size: 15.45px; font-family: serif; transform: scaleX(1.06804);" data-canvas-width="147.10049999999995">) World Federation of</div><div style="left: 70.8662px; top: 524.72px; font-size: 15.45px; font-family: serif; transform: scaleX(0.977376);" data-canvas-width="422.00250000000005">Societies of Biological Psychiatry (WFSBP) Treatment Guideline for</div><div style="left: 70.8662px; top: 544.72px; font-size: 15.45px; font-family: serif; transform: scaleX(1.00461);" data-canvas-width="190.43549999999996">Unipolar Depressive Disorder;</div><div style="left: 261.219px; top: 545.947px; font-size: 9.00733px; font-family: serif; transform: scaleX(0.981106);" data-canvas-width="10.301609999999998">[6]</div><div style="left: 271.558px; top: 544.72px; font-size: 15.45px; font-family: serif; transform: scaleX(1.25945);" data-canvas-width="44.290499999999994">and (</div><div style="left: 315.754px; top: 544.52px; font-size: 15.45px; font-family: serif; transform: scaleX(0.902161);" data-canvas-width="14.716499999999996">vii</div><div style="left: 330.385px; top: 544.72px; font-size: 15.45px; font-family: serif; transform: scaleX(1.07299);" data-canvas-width="164.74800000000002">) British Association for</div><div style="left: 70.8662px; top: 564.72px; font-size: 15.45px; font-family: serif; transform: scaleX(0.939612);" data-canvas-width="195.08699999999996">Psychopharmacology Guidelines.</div>[7