bluuebunny/crossref_metadata_2025 huggingface dataset:
A case of white bean allergy
Authors: Matsui Teruaki , Sato Nayu , Nakamura Masashi , Iwawaki Yukiko , Kitamura Katsumasa , Takasato Yoshihiro , Sugiura Shiro , Matsunaga Kayoko , Ito Komei
Published: February 2024

White bean allergy is uncommon and rarely reported. Herein, we report a case of white bean allergy in a patient with Down syndrome. A 7-year-old girl with Down syndrome experienced allergic symptoms twice after eating white bean and visited our hospital for a food allergy investigation. An ImmunoCAP assay revealed a white bean-specific IgE (13.4 kUA/L) in the patient’s serum. In addition, her skin prick test result was positive. Moreover, ingestion of 2 g of boiled white beans in an oral food challenge test induced intermittent cough, desaturation, generalized urticaria, abnormal sleep, and mild hypotension. Thus, we diagnosed the patient with white bean allergy. We performed western blotting and mass spectrometric analysis and detected the following allergens: Phytohemagglutinin, group 3 late embryogenesis abundant protein, lipoxygenase, and legumin. In addition, we detected several candidate allergenic proteins for the first time. White bean, runner bean, or azuki bean was considered the primary source of sensitization because although immunoblotting inhibition tests revealed that the abovementioned beans inhibited other legumes, soybean, which she tolerates, showed little inhibition of the other legumes. However, we could not confirm whether the patient could ingest legumes other than soybean or white bean because her family did not wish to continue with further testing. This is the first report of a case of systemic allergic reactions to white bean in a child with Down syndrome. Further studies are needed to identify white bean allergens and understand the relationship between Down syndrome and white bean allergy.
Aiming at the clarification of architectural presence: a theoretical framework
Authors:   Department of Architecture, Isfahan Branch, Islamic Azad University, Isfahan, Iran, Shahani Mohammadhossein
Published: February 2024

The present paper seeks to discuss the principles of a theoretical framework aiming at the clarification of architectural presence. Hence it briefly explains the philosophical notion of presence in art and architecture. The tendencies to define architecture through the notion of presence delineate that the history of architecture has been a significant source for the theoretical framework to clarify the presence. As prominent modern architects have presented clarity in their designs, this article explores the fundamentals of architecture for dealing with the clarification. The description of the principles shows that they are related to order, natural light, space, and form, as the primary concerns of design. These principles then present several features by the clarification of the presence. The paper finally explains the specific outcomes of the clarification.
Architecture and the politics of nationalism in the era of globalization
Authors:   Department of Architecture, Abubakar Tafawa Balewa University Bauchi, Nigeria, HUSSAINI Ibrahim Udale , WAKAWA Bukar Usman , UMAR Aminu , ELNAFATY Abbas Said
Published: February 2024

Architecture is a physical force and a communication medium that speaks to power of value and ideals of a society through effective communication of socio-political messages embedded in its physical configurations. It helps to create the physical as well as the political institutions of establishments in the society that embodies the civilization codes of “law and order.” However, the power of architecture as a political propaganda tool is reminiscent of nationalism in many facets and circumstances. In the past imperial establishments, the ruler used architecture as a control tool to influence the people’s perception of the state and the achievements of the civilization. Whereas, the later civilization of globalization in the 21st century helps to create the institutional establishments of democratic architecture with a renewed strategy to wield power to entertain and gain political and socio-economic supports for the governments and corporate organizations. This review therefore demonstrates the role of architecture in the politics of power and influence vividly evident in the emergent democracies and some current establishments of globalization, a case reference of Dubai.
The architectural features of nursing homes affect the residents' sense of home
Authors:   Department of Architecture, Islamic Azad University, Shabestar Branch, Shabestar, Iran, ALIYARI Mahdi
Published: February 2024

Following the increase in the elderly population in Europe and other parts of the world, taking proper care of elderly people has recently become a significant concern in Iran as well. The architecture and design of nursing homes can have a profound impact on the sense of home and well-being of the elderly residing in these facilities. Therefore, the aim of this study is to determine the relationship between influential architectural factors in the nursing homes of District 10 of Tehran and the sense of home among the elderly. The research method used in this study was descriptive correlational, and data collection was carried out in two stages: library and documentary research, as well as field survey. A purposive sample of 45 elderly residents of nursing homes in District 10 of Tehran were studied using two questionnaires on design and architectural factors of nursing homes and the motivation for living. The results showed that the correlation coefficients of the design and architectural factors and their components concerning lighting, public private and spaces, accessibility, and green spaces with the sense of home among the elderly were 0.521, 0.224, 0.621, 0.413, 0.281, and 0.403, respectively. Based on the findings of this research, it can be concluded that the design aspect has a direct impact on the formation of the sense of home in the elderly, and it is not possible to separate the physical and environmental aspects from the psychological dimension of the elderly.
A review of limitations and future challenges in optimization of energy in sustainable high-rise buildings
Authors:   Department of Architecture, Central Tehran Branch, Islamic Azad University, Tehran, Iran, KADAEI Samireh
Published: February 2024

Sustainability has been one of architecture’s most significant trends over the last twenty years. Environmental consciousness of professionals has put sustainability at the heart of the architectural profession and has contributed to adopting and implementing sustainable designs on the scale of urban landscapes. Buildings consume 40% of global energy, in which high-rise buildings account for a significant proportion of the total energy used. Hence, present study reviews limitations and future challenges in optimization of energy in sustainable high-rise buildings. Results of this study show that budget limitations, managerial and organizational policies, legal issues, technical and scientific infrastructure, and cultural and geographical aspects are all affecting the widespread use from energy optimization in current high-rise buildings and need to be considered in future studies.
Assessment of Bacteriological Contamination of Hand-Dug Wells in Rural and Urban Areas in Ondo State, Nigeria
Authors: Ojo Joy T. , Ojo Ochuko M. , Olabanji Taiwo O. , Aluko Rebecca T.
Published: February 2024

The study analysed the total bacteria, total coliform and Escherichia coli (E. coli) concentrations of ten randomly selected hand-dug groundwater wells: five each from Alagbaka (Urban area) and another five from Ijare communities (Rural area) in Ondo State. Collins and Lyne’s pour plate method was used for the laboratory analysis. The laboratory results showed that 30%, 90% and 0% of the groundwater samples were above the WHO drinking water standards for total bacteria, total coliform and E. coli, respectively. Furthermore, the groundwater samples collected in the urban study area had total bacterial and total coliform mean levels of 24 and 15 cfu/100mL respectively compared to those of the rural study area with mean concentrations of 15 and 5 cfu/100mL, respectively. There was however no E. coli in the groundwater of both areas studies indicating the absence of faecal contamination in groundwater. It can therefore be concluded that there is a higher risk of microbial contamination of groundwater in urban land use than in rural land use and that groundwater in the study areas is unsafe for consumption unless it is first treated with appropriate treatment methods. For future research, the contamination level of other micro-organisms such as fungi, viruses, protozoa etc. should be assessed in study areas, as well the sources of microbial contamination in groundwater.
Morphometric and microbiological features of ventilator associated tracheobronchitis
Authors:   State Institution “Republican Specialized Scientific and Practical Medical Center for Surgery named after academician V.Vakhidov”, Uzbekistan, IBADOV Ravshan Aliyevich , AZIZOVA Gavhar Mahmudkhanovna , IBRAGIMOV Sardor Khamdamovich
Published: February 2024

Changes in the composition of the microbiota of the tracheobronchial tree in patients on prolonged mechanical ventilation can contribute to various disorders of the immune defense of the respiratory tract, damaging mucociliary clearance, and cause a strong inflammatory response, including the formation of ventilator-associated tracheobronchitis (VAT). The aim was to study the specifics of changes in the microflora and histopathology of the tracheobronchial tree in VAT. Over a 10 year period 975 bacteriological analyzes were carried out in 355 patients who were on extended mechanical ventilation for more than 48 hours. VAT is accompanied by a pronounced lymphoid-neutrophilic infiltration of the mucosa of the trachea and bronchi, and in a complicated course with the presence of a purulent-inflammatory and erosive-hemorrhagic component leads to a violation of the integrity of tissues due to destruction and necrosis. The leading pathogens were representatives of gram-negative flora of 65.8% (47-76%), gram-positive flora was detected in 17.5% (10-30%) of cases, fungi of the genus Candida in 16.5 (4-42%) cases. Analysis of the antibiograms of isolated cultures in patients on prolonged mechanical ventilation shows high resistance to a wide range of antibiotics, namely: acinetobacter spp. - high resistance to all antibiotics, except for imipenem (0% resistant strains), polymyxin (0%) and tetracyclines (7-15.4%). Imipenem (10.5%), polymyxin (10.5%), amikacin (31.5%) and cefoperazone/sulbactam (31.5%) are active against Esherichia coli. Klebsiella pneumoniae was susceptible to imipenem, amikacin, ofloxacin and inhibitor-protected antibiotics-cefoperazone/sulbactam, piperacillin/tazobactam. Staphylococcus aureus was susceptible to III generation cephalosporins (cefotaxime, ceftriaxone, cefoperazone) and tetracyclines - 36.3% of resistant strains. Microbiological monitoring in patients with VAT over a 10-year period revealed a trend towards the prevalence of gram-negative microflora inoculation, and over the past two years, the range of isolated multi-resistant flora has been expanding.
COVID-19-induced cardiovascular complexities
Authors: IBADOV Raufbek Ravshanovich , AKILOV Khabibulla Ataullaevich , IBRAGIMOV Sardor Khamdamovich
Published: February 2024

This study aimed to investigate the features of the clinical course of COVID-19 in combination with the pathology of the cardiovascular system (CVS). A prospective study was carried out. The main group (n=150) consisted of patients with changes in the cardiovascular system associated with COVID-19, i.e. newly diagnosed CV pathology, and patients with exacerbation of cardiac pathology against the background of COVID-19. The comparison group (n=154) included patients with COVID-19, but without any significant concomitant cardiac pathology. The average age of patients in the main group was 67.7 years (from 47 to 86 years), in the comparison group of 66.1 years (from 48 to 88 years). The study groups were representative and did not differ statistically in the nature of COVID-19 symptoms and the degree of lung involvement. Among the cardiac pathology, progressing or first occurring against the background of infection with COVID-19, in most cases, arterial hypertension of II-III degree (60.0%), coronary heart disease (48.7%), arrhythmias (23.3%) were diagnosed. Echocardiographic abnormalities included right ventricular dysfunction (22.7%), left ventricular contractility disorders (18.7%), with decreased ejection fraction (17.3%), diastolic dysfunction (14.0%), and toxic myocarditis (7.3%). The most significant risk factors were the presence of a burdened medical history (RR=10.39), elevated body mass index over 30 (RR=2.63) and diabetes mellitus (RR=1.55). In patients with COVID-19 in combination with CVS pathology, a relatively high incidence of acute onset (64.0% vs. 44.2%; p<0.001), respiratory failure (83.7% vs. 62.0%; p<0.001), admission to the intensive care unit (25.3% vs. 11.7%; p=0.004), development of acute respiratory distress syndrome (20.0% vs. 9.1%; p=0.012), hospital mortality (10.7% vs. 2.7%; p=0.006). Cardiac manifestations of COVID-19 included focal or global myocardial inflammation, ventricular dysfunction, heart failure, and arrhythmias. A high frequency of acute onset of the disease, respiratory failure and hospital mortality is determined.
MAKNA PENCATATAN PERKAWINAN PADA PERATURAN PERUNDANG-UNDANGAN DITINJAU DALAM HUKUM ISLAM
Authors: Anto Adrianto
Published: February 2024

Abstract

This research is motivated by invalidity unregistered marriage based on Positive law and Islamic law. In Islamic law marriage registration is condicio sine quanon is istinbath of Islamic law. Marriages that are not registered according to the regulations of Islamic law for condicio sine quanon for marriage registration be a contradictory matter what happens in practice wedding in the middle of public. This study aims to determine The mean a recording of marriage In istinbath of islamic law and want to know in mean of recording of marriage in islamic law And want to know the mean of recording of marriage in an effort to realize goals Maslahah which is on public. This research uses qualitative approach with library research. The research results show abouth the recording of marriage is condicio sine quanon in istinbath of Islamic law and meaning of recording of marriage in Islamic law is is as evidence next to the witnes. The mean of recording of marriage in an effort to realize goals Maslahah which is on public as Maslahah Daruriyyah like a guard that must be maintained Is ad-Din, an-Nafs, al-‘Aql, an-Nasab wa al-Mal.

 

AbstrakPenelitian ini dilatar belakangi oleh ketidakabsahan pernikahan yang tidak dicatatkan berdasarkan hukum positif dan hukum Islam. Dalam hukum Islam pencatatan pernikahan adalah sebagai syarat mutlak dalam istinbath hukum Islam. Pernikahan yang tidak dicatatkan dengan aturan hukum Islam mengenai syarat mutlak bagi pencatatan perkawinan menjadi perkara yang kontradiktif yang terjadi dalam praktek pernikahan di tengah masyarakat. Penelitian ini bertujuan untuk mengetahui makna pencatatan perkawinan dalam istinbath hukum Islam dan ingin mengetahui makna pencatatan dalam hukum Islam. Serta ingin mengetahui makna pencatatan pernikahan dalam upaya merealisasikan tujuan maslahah yang ada pada diri manusia. Penelitian ini menggunakan pendekatan kualitatif dengan metode kepustakaan (library research). Hasil penelitian menunjukan bahwa makna pencatatan pernikahan adalah syarat mutlak dalam istinbath hukum Islam dan makna pencatatan pernikahan adalah sebagai alat bukti di samping saksi dalam hukum Islam. Makna pencatatan pernikahan dalam upaya merealisasikan tujuan maslahah yang ada pada diri manusia adalah Maslahah Daruriyyah seperti penjagaan yang harus dijaga adalah ad-Din, an-Nafs, al-‘Aql, an-Nasab wa al-Mal.
Alternative Forms of Mobility in an Emergency Remote Teaching Context: A Study of Greek Undergraduate Students’ Attitudes
Authors: Blanta Aikaterini , Karras Ioannis
Published: February 2024

Since the outset of the COVID-19 pandemic, there has been a lot of talk about alternative ways of student mobility. Higher Education Institutions are adopting new forms of mobility to provide flexibility. Among them, hybrid mobility and internationalisation activities at home are offered to university students. Within this framework, a preliminary study has been conducted to investigate Greek undergraduate students’ attitudes towards alternative solutions devised by Higher Education Institutions in an emergency remote teaching context in a time of global crisis due to the coronavirus. In essence, the present study addresses the following research question: How do undergraduate university students in Greece view hybrid mobility or internationalisation activities at home compared to physical mobility? More specifically, 57 students from two public universities in Greece completed an online questionnaire and five students were interviewed. Both the questionnaire and the semi-structured interviews were designed to measure students’ attitudes towards physical mobility, hybrid mobility and home-based internationalisation. The findings demonstrate that although the pandemic has not notably affected students’ attitudes towards Erasmus+ mobility, most of them prefer physical mobility to alternative forms of mobility as it provides a more complete and unique experience. The findings obtained herein are used to make suggestions on alternative ways of making home-based, online and blended internationalisation activities more effective, inclusive and engaging in the years to come.
Posteromedial Periarticular Injection in Total Knee Arthroplasty: A Cadaveric Study
Authors: Christopher Zachary K. , Clarke Henry D. , Spangehl Mark J. , Bingham Joshua S.
Published: February 2024

Achieving optimal pain control in total knee arthroplasty has improved with the use of regional anesthesia and periarticular injections (PAIs). When performing a PAI, the relative location of the anesthetic spread is not well defined in comparison with an adductor canal block (ACB). In this study, our aim was to evaluate the location of posteromedial PAI spread compared with a surgeon administered ACB. One PAI and one surgeon-administered ACB were performed in the contralateral limbs of four human cadavers. The injectate was composed of methylene blue dye to visually inspect the dye spread from the tip of the needle. Dissections were performed on each cadaver to quantify the dye spread from the tip of the needle and compare the location of the dye spread. Dye spread location was characterized as either entering the adductor canal or including the posterior capsule. The mean distance of dye spread from the needle tip to the proximal most aspect of the dyed tissue was 10.125 cm in the ACB group compared with 6.5 cm in the posteromedial PAI group. In the ACB group, 4 of 4 injections were present in the adductor canal block group compared with 3 of 4 in the posteromedial PAI group. The posteromedial PAI group also had 3 of 4 injections involve the area around the posterior capsule compared with 0 of 4 in the ACB group. Posteromedial PAI appears to provide local delivery to both the adductor canal and the posterior capsule. Intraoperative, surgeon-administered ACB reliably delivers injectate to the adductor canal only but may allow for more proximal dye spread. Posteromedial PAI may provide a benefit in delivering injectate to the posterior capsule in addition to the ACB. Additional clinical studies are necessary to determine the clinical effects of this finding.
Evaluation of Medical Students’ Knowledge and Their Adherence to Safety Measures Regarding Solar Ultraviolet Exposure
Authors: Hafalish Hana
Published: February 2024

Ultraviolet radiation, a type of electromagnetic radiation, can be released by both artificial and natural sources, including the sun. It is imperative to adopt the appropriate safety measures when close to an ultraviolet radiation source, as unprotected UV radiation exposure has been associated with a higher risk of developing various illnesses, such as skin tumors. This study aims to evaluate undergraduate medical students' knowledge of potential hazards from UV radiation exposure and their practice of safety measures. A cross-sectional study was conducted at Omar Al-Mukhtar University, Al-Beyda City, Libya. One hundred and nine medical students were involved in this study. The questionnaire examined participants' knowledge of and behavior toward potential risks associated with ultraviolet (UV) radiation exposure. Notably, 77.1% of them were female, and 22.9% were male. The majority of the respondents were more than 22 years old. Above half, 59.6% showed moderate knowledge about UV exposure consequences; most of the students, 91%, knew the side effects of UV on health, followed by 86%, who indicated that UV can cause premature aging and cancer. In contrast, less than a third knew that UV has a negative impact on the immune system, and about two-thirds (73.9%) didn't realize that sunburn can occur even on a cloudy day. Although medical students showed a moderate level of knowledge regarding UV radiation, there was a lack of active sun safety measures.
Mastalgia Among Women Attending the Outpatient Clinics in Alwahda Teaching Hospital, Derna
Authors: Ajroud Soad , Bojazyah Aisha , Bohlala Mohammed
Published: February 2024

Mastalgia, also known as mastodynia or breast pain, is a common symptom in clinical practice, with a prevalence ranging from 50% to 80% among women throughout their lives. While only a minority of women may require treatment, a proper assessment is essential for all patients to rule out underlying breast pathology. Addressing concerns, particularly the fear of harbouring cancer and the impact of severe pain on daily life, is crucial. This cross-sectional study aimed to determine the prevalence of both cyclical and non-cyclical mastalgia, identify underlying risk factors, and assess its impact on women's quality of life. A total of 580 patients were included in the study and evaluated using a closed-ended questionnaire. Among the 580 women studied, the prevalence of mastalgia was found to be 60%, with 43% experiencing noncyclical mastalgia. The majority of individuals experiencing mastalgia onset fall within the age range of 16-25 (41.7%). Mastalgia was positively correlated with stress (99.2%), a positive family history of mastalgia (22%), average body habitus (47.9%), lack of physical exercise (78.4%), high fat diet (20.8%) and excessive coffee intake (25%), a personal history of chronic illness (48.8%). It showed a weak correlation with other factors such as oral contraceptive pills (2.3%) and a positive family history of breast cancer (14.4%). The pain was primarily focal, unilateral, and of mild to moderate severity. Notably, 75% of cases had not undergone breast cancer screening despite their cancer phobia (64.6%). Improving mastalgia management requires increased awareness among women about its risk factors, reassurance, lifestyle modifications (such as regular exercise), and the use of local analgesics.
Pacuan Dende: A virtual reality game that educates players about tropical infectious diseases and how they contribute to stunting
Authors: Jiwintarum Yunan , Diarti Maruni , Anulus Ayu
Published: February 2024

Objective: To develop a virtual reality (VR) game that educates players about tropical diseases and how they contribute to stunting
Methodology: This study used Design Science Research about VR game design derived from literatures about tropical diseases that can cause stunting. Within the VR game, respondent could interact with the story to learn about tropical diseases including malaria, diarrhoea, worms, and Acute Respiratory Infections (ARI).
Results: A total of 5 adolescents were used to contribute as the player. There was good quality acceptance among adolescents who contributed as the player.
Conclusion: We succeeded in designing a virtual reality game to educates players about tropical diseases and how they contribute to stunting.
Mapping collaboration networks in community health nursing research: A bibliometric analysis
Authors: Alshammari Mukhlid , Alnassry Soad , Qaladi Omar , Mohamedsalih Wahieba , Mamanao Daniel , Mohamed Sara
Published: February 2024

Objective: To conduct a bibliometric analysis of community health nursing research from 2019-2023 to identify publication trends, influential entities, research themes, and collaboration patterns.
Methodology: Data on 870 community health nursing publications from 2019-2023 was retrieved from Web of Science database. Quantitative and network analysis were conducted using VOSviewer and R programing softwares to examine trends and collaboration patterns.
Results: The study included 870 community health nursing publications from 2019-2023. Annual output peaked in 2021, then declined. Average citations per article decreased over time. Public Health Nursing published the most articles, with output increasing annually. Yoshioka-maeda was the most productive author. The University of California System led affiliations. The United States dominated production and international collaborations. Keyword analysis revealed clusters around vulnerable groups, interventions, mental health, risks, and populations. Country collaboration network mapping showed robust North America-Europe links. The United States exhibited the most co-authorships.
Conclusion: This bibliometric analysis of community health nursing research from 2019-2023 provides insights into publication trends, influential authors, sources, countries, research themes, and collaboration patterns. Tracking changes over time and expanding diversity could further advance the field.
Quadrant of difficulty and usefulness for prioritizing community-based disaster preparedness parameter elements
Authors: Sunarto Sunarto , Nugroho Heru , Suparji Suparji , Santosa Budi
Published: February 2024

Objective: To prioritize building elements for community-based disaster preparedness parameters, so that priority elements were obtained that had very high benefits but the way to realize them was very difficult.
Methodology: This descriptive study included 345 administrators of disaster risk reduction forums and community leaders who were selected using a stratified sampling technique. The research variable was the disaster preparedness parameter. Data were collected by filling out the DUEDP-Questionnaire, which contains attributes of difficulty and usefulness. Data were analyzed using the Quadrant of difficulty-usefulness method and then presented in 4 quadrants.
Results: The five parameters of disaster preparedness are knowledge and attitudes (KA), policies (P), emergency response plans (ERP), early warning system (EWS), and resource mobilization (RM). The priority to be realized first is resource mobilization and an early warning system. The priority element as a parameter construct for resource mobilization that must be immediately realized by the disaster risk reduction forum is to train families to be prepared to provide disaster preparedness bags, especially in disaster-prone areas. The priority elements as a parameter construct for an early warning system that will immediately be realized by the disaster risk reduction forum are providing early warning tolls, agreeing on forms of communication of the early warning system to vulnerable and disabled groups, and agreeing on how to respond to the community if there is an early warning of the danger of disaster.
Conclusion: Of the five disaster preparedness parameters, what needs to be worked out first by the disaster risk reduction forum for disaster-resilient villages are resource mobilization and an early warning system.
Determinant factors of students’ refusal assertiveness of illicit drugs in Bima indonesia: a logistic regression analysis
Authors: Ahmad Ahmad , Dramawan Awan , Martiningsih Martiningsih , Wulandari Ade
Published: February 2024

Objective: To determine factors correlated with students’ refusal assertiveness of illicit drugs.
Methodology: This cross-sectional study was carried out in four junior and senior high schools in Bima from January to October 2023. The sample consisted of 202 students who were selected by simple random sampling method. Data were collected using a self-administered questionnaire. Study was carried out in two parts. First, sociodemographic information about the participants and the second part about knowledge and attitudes toward protect oneself from drug abuse. Data analysis consists of the Chi square test and multivariable logistic regression analysis.
Results: Students age was 12-17 years, and out of 202 students, 84 were boys and 118 girls. Mean age at enrollment was 14,67±0,932 years. More participants lived in rural areas of Bima. Based on age, sex, grade of school and area of residence, studeents received counseling on drug abuse prevention and knowledge of drugs. Logistic regression shown that the determinant factors of students' refusal assertiveness of illicit drugs were age (OR 1,6) and gender (OR 0,4) while the region of residence variable was a confounding factor.
Conclusion: The determinant factors of students' refusal assertiveness of illicit drugs were age and gender.
Common radiological findings in victims of intimate partner violence: A narrative review
Authors: Alkhaldi Waleed
Published: February 2024

Physical, sexual, or emotional abuse by a current or former partner or spouse is known as intimate partner violence (IPV). It is the most prevalent type of violence against women. It's also the easiest to avoid among violent acts. Clinical decision making is influenced by imaging findings associated with IPV. Evaluation of pertinent patient demographic, trauma, and common radiological factors was conducted to determine the prevalence, nature, and severity of injuries in IPV patients. Medical experts often misdiagnose IPV, which affects millions of women. Radiologists and other healthcare personnel might raise awareness of this "invisible" yet pervasive public health issue by integrating adult IPV diagnosis in core training and employing machine learning. Longitudinal imaging and clinical data provide objective information and warnings that can change victim treatment and aid law enforcement.
Level of stress among first line nurses in East Jeddah Hospital, Saudi Arabia during COVID-19 pandemic
Authors: Alsharabi Mohammed , Albarqi Yahya , Alshamrani Mohammed , ALhabanji Fahad , Alqarni Abdulrahman , Alharbi Mishari
Published: February 2024

Objective: To determine the level of occupational stress and the associated factors among first line nurses in East Jeddah Hospital, Saudi Arabia, during COVID-19.
Methodology: Data were collected from 250 first line nurses working in East Jeddah Hospital using survey questionnaires. The questionnaires consisted of occupational stress scale. The collected data were analyzed using Chi-square and descriptive statistical tools of SPSS.
Results: We found that 82.8% of the nurses had high level of stress and only 17.2% had moderate stress. The level of occupational stress was affected by various demographic factors, including nurses’ age (p=0.000; r=.713), level of education (p=0.000; r=.655) marital status (p=0.014; r=.624), and whether the nurses stayed alone or with others (p=0.000; r=.507). Many work-related factors affect the level of occupational stress, including department of work (p=0.040; r=.756), hours of working (p=.000; r=.542), years of experience (p=.002; r=.734), access to PPEs (p=0.000; r=.594), nature of relationship with the other coworkers (p=0.000; r=.594) and nature of work relationship (p=0.000; r=.597).
Conclusion: The high level of stress among the first line nurses varies with sociodemographic and work factors. This calls for the healthcare systems to implement devise measures to address the propagating factors around stress among these nurses.
Type 2 diabetes management: A systematic review of cognitive behavioral therapy, dietary patterns and physical activities
Authors: Alsulami Amal
Published: February 2024

Objective: To identify the relationship between dietary patterns, physical activity, and cognitive behavioral therapy (CBT) in patients of Type 2 Diabetes (T2D).
Methodology: A review of studies from specified electronic databases was conducted to find relevant studies published between 2015 and 2022. PICO format was used to determine which studies to be included. Data extraction and appraisal assessment by multiple reviewers was conducted to synthesize the results. Eight studies met the criteria, focusing on physical activity, diet, or CBT in adults with T2D.
Results: Positive effects of these interventions were found on patient outcomes and quality of life. The evidence strength was moderate. Physical activity, diet, and CBT improved quality of life and symptoms of diabetes.
Conclusion: This systematic review showed the significance of physical activity, diet, and CBT in diabetes management and improving diabetes symptoms. This lead to better glycemic control, lifestyle changes, self-management, and overall better health status. Further research should explore the integration of CBT with physical aspects to optimize diabetes management and promote patient well-being.
Evidence-Based Practice in Nursing: Implementation, Effectiveness, and Strategies for Improved Patient Outcomes
Authors: Mohammed Insaf , Osman Amal , Crisostomo Maria , Castillo Ana , Adriano Jermilyn , Manahan Filipinas
Published: February 2024

Objective: To assess evidence-based practice (EBP), its implementations, effectiveness, and strategies for improved patient outcomes.
Methodology: The review synthesizes recent studies and systematic reviews across various nursing specialties and settings to assess the effectiveness of evidence-based practice.
Results: EBP had positive impacts on patient outcomes, including reduced morbidity and mortality rates, improved patient satisfaction, and enhanced healthcare delivery. We identified barriers to EBP implementation and presents successful strategies for overcoming these challenges.
Conclusion: The study enhances patient outcomes and promotes the delivery of high-quality care in nursing, contributing to the continuous advancement of EBP in healthcare.
Effect of exercise training on Type 2 diabetes management and lipid profile
Authors: Elfaki Nahid
Published: February 2024

Objective: To evaluate the effect of exercise training on glycemic control and levels of lipid among diabetic patients.
Methodology: This randomized controlled trial (RCT) was conducted in Upper Nile University, Sudan from January 2022 to April 2023. It was registered on Iranian Registry of Clinical Trials (the registration reference is IRCT20230827059278N1). Forty patients with type 2 diabetes mellitus were allocated to the intervention group from the Jaber Abuelez Diabetic Center and Sameer Primary Healthcare Center, and the control group was taken from Tooty Primary Healthcare Center and Shambat Primary Healthcare Center. For a whole year, the intervention group had exercise instruction. Lipd profile and HgA1c were assessed before and after the exercise training to evaluate the effect. SPSS was used to analyze the data.
Results: Exercise training resulted in a significant decrease in levels of triglycerides (-42.11, p<0.05), LDL (-8.92, p<0.05), HDL (+4.5 for males and +8.96 for females, p<0.05), and HbA1c (mean difference: -0.6, p<0.01). There was a significant reduction in LDL (-10.22, p<0.05), HbA1c (-0.69, p<0.05), and triglycerides (-33.07, p<0.01).
Conclusion: The exercise training is a useful strategy for maintaining lipid profiles and controlling blood sugar in patients with type 2 diabetes.
Clinical profile of paraphenylenediamine intoxication
Authors: Ali Mujtaba
Published: February 2024

Hair dyes are widely used for decorative skin paint, nail coloring, and hair dye. Hair dye toxicity has been attributed to adding a synthetic dye paraphenylenediamine (PPD). PPD is added to natural henna to accentuate the dark color and shorten the duration of application. PPD self-harm or accidental toxicity is well-known in developing countries and extensively reported in the medical literature.
Acute intoxication with PPD causes characteristic severe angioedema of the pharynx and larynx which usually necessitates tracheostomy, and it is associated with facial and tongue edema. PPD poisoning results in multisystem disorders and can cause rhabdomyolysis and acute kidney injury, aggressive gastrointestinal manifestations, pancarditis, and arrhythmias. This form of severe poisoning is fatal if not treated early and properly. There is no specific antidote and treatment is mainly supportive and helpful only if initiated early.
Investigation of the frequency of clinical risk factors of covid-19 in hospitalized patients in Valiasr hospital, Qaemshahr, Iran
Authors: Omraninava Melody , Neserkani Fatemeh , Mohammadzadeh Kayvan , Alishah Hosseinali , Valiandoost Mahmud , Mohammadi Iraj
Published: February 2024

Objective: To evaluate the frequency of clinical risk factors for COVID-19 in patients admitted to Valiasr Hospital in Qaemshahr.
Methodology: In this descriptive cross-sectional study conducted at Valiasr Hospital in Qaemshahr, cases of patients with COVID-19 from March 2020 to November 2020 were examined. Severity, and underlying conditions were assessed.
Results: The study included a predominantly male population (53.1%), with average of 63 years. Symptom severity varied, with 51.9% experiencing moderate symptoms. Common underlying conditions contributing to disease severity were diabetes (42.7%), blood pressure issues (39.3%), and cardiovascular diseases (33.5%). The mortality rate was 25.9%, with the highest death rate among patients with severe symptoms (72.5%) and those hospitalized in the ICU (45.6%).
Conclusion: Older age, male gender, and prolonged disease duration were identified as factors associated with a higher likelihood of severe COVID-19 cases, increased chances of ICU hospitalization, and elevated mortality rates, especially for individuals with underlying health conditions.
Extracellular Vesicles in Glioblastoma
Authors:   , Schweiger Markus Werner
Published: February 2024

This thesis aims to advance our understanding of how EVs contribute to the pathogenesis and treatment resistance of GBM with the goal of informing future treatment and research.
In the first part of the thesis, we examine GBM and analyze the pre-clinical models used for studying its properties (Chapter 2). Furthermore, we investigate EVs and evaluate methodologies for tracking them (Chapter 3).
In the second part, we explore the role of EVs on the GBM TME. First, we examine the effects of EVs on intratumoral heterogeneity in GBM, highlighting their role in increased invasiveness and therapeutic resistance (Chapter 4). Next, we try to understand the effect of EVs on immune cells in the TME, focusing on myeloid cells, the most prevalent one (Chapter 5). We demonstrate how GBM EVs induce a tumor-associated phenotype in recipient myeloid cells and investigate this in the context of radiation.
In the third part, we synthesize insights from Part 1 and Part 2 to devise a novel AAV-based gene therapy approach against GBM (Chapter 6).
In the fourth part, we investigate how olfactory receptors expressed on cancer cells modulate invasion, migration, and metastasis, which resulted in the proposition of olfactory receptor 5B21 as a novel oncogene (Chapter 7).
In the final section, we discuss the core findings, point out limitations, and provide recommendations for future studies (Chapter 8).
2023 KAHRAMANMARAŞ MERKEZLİ DEPREMLERDE ENKAZ ALTINDA KALAN KIBRIS TÜRK VOLEYBOL TAKIMI HABERLERİNDE DOĞRULUK SORUNU: ENFORMASYON, MİSENFORMASYON, DEZENFORMASYON
Authors: ÖZE Nuran
Published: February 2024

Deprem, önlem alınmadığında felakete dönüşebilen doğal bir olaydır. Çalışma, 6 Şubat 2023 tarihinde Kahramanmaraş merkezli meydana gelen, 11 ili etkileyen depremlerle ilgilidir. Kuzey Kıbrıs'tan Türkiye'deki voleybol müsabakalarına Adıyaman’da katılmak için giden 39 kişilik kafileden dört kişi depremden sağ kurtulmuş, yaşları 12-14 arasında değişen 24 sporcu hayatını kaybetmiştir. Toplam 49 KKTC vatandaşının hayatını kaybettiği bu depremler, Kıbrıs Türklerinin 1974 savaşından sonra yaşadığı en büyük ve toplu kayıptır. Olayın akabinde Cumhurbaşkanı eski İletişim Danışmanı ve Cumhurbaşkanlığı sözleşmeli personeli Kartal Harman kendi sosyal medya hesabından Adıyaman’daki ekipten iyi haberler alındığına dair yaydığı asılsız haberlerle çocukların aileleri ve toplumu yanıltmış, umutlanmasına neden olmuştur. Çalışmanın amacı, bilgi, misenformasyon ve dezenformasyonun doğrulukla olan sorunlu ilişkisini incelemek, doğru haberciliğin önemine değinmek ve haberlerde dezenformasyonu önleyebilecek öneriler yapmaktır. Amaca ulaşmak için dezenformasyona sebep olan haberler elektronik arşiv taraması ile saptanmış, ardından 219 kişi üzerinde alan araştırması yapılarak haber kaynakları ve bu kaynaklara güven ilişkisi bağlamındaki sorular katılımcılara elektronik anketlerle ulaştırılmış, sonuçlar doğrultusunda depremlerle ilgili haberlerin Kuzey Kıbrıs’ta en çok takip edildiği gazeteciyle yüz yüze görüşme gerçekleştirilmiştir. Katılımcıların ana akım medya kanallarına güveni çok düşükken, sosyal ağlardan alınan haberlere geleneksel medyada yayınlanan haberlere göre daha çok güvendiği ancak sosyal medyayla ilgili ciddi güven sorunları yaşadığı saptanmıştır. Misenformasyon ve buna bağlı dezenformasyon bunun temel sebebi olarak belirlenmiştir.
WHICH POWER DECIDES ON THE BASIC HUMAN GOODS OF JOHN FINNIS' NATURAL LAW THEORY IN BRAZILIAN DEMOCRACY?
Authors: Campelo Clidenor Marcos Vaz , Matos Nelson Juliano Cardoso
Published: February 2024

The work presents a description of the basic human goods in Finnis' theory (2007), which are: knowledge, life, play, aesthetic experience, friendship, practical reasonableness and religion. To then question which power has the basis to decide on basic human goods in a democracy. The article brings jurisprudence from the Federal Supreme Court in which the court ruled on basic human values, that is, basic human goods shaped outside the political arena, configuring a possible obstruction of the channels of democratic alternation and popular control. To explain the strengthened judiciary power, the text repeatedly uses Hirschl's theory (2020), which asserts that one of the causes of the strength of the judiciary is the avoidance of politicians in making difficult moral or political decisions, which, once decided, rarely present absolute numbers. of winners, therefore, with political spoils that are difficult to manage. This movement between powers causes a transfer of the locus of political debate, which migrates from the powers constituted by direct representatives of the people to the courts, reaching the doctrine about the separation of powers and democracy, otherwise let's see: basic human goods being designed by judges in to the detriment of powers that reveal popular sovereignty. The tension between democracy and judicial control of pure politics, apparently, is revealed when we analyze that a counter-majority court would have the last word in democratic processes for delineating the major political issues of a country.
Biotechnological Production of Butanol
Authors: Branská Barbora
Published: February 2024

The biotechnological production of butanol and other accompanying solvents has a history of more than a century and currently represents an alternative to produce desirable chemicals from various waste streams, in accordance with the concept of the circular economy. This review article summarizes the current state of potential industrial production, introduces the main solvent producers, solventogenic clostridia and their metabolism, together with the main aspects that influence physiological and production characteristics. The last part is devoted to substrates that can be used for biobutanol production, in particular lignocellulose, a ubiquitous waste plant matter, with great potential in connection with the large-scale biotechnological production of many commodities.
Change in Religious Understanding and Language Shift of the Recitations of the Quran and Hadith in the Perspective of Islamic Jurisprudence
Authors: Ushalli Eskarni , Salma  , Hayati Naila , Yuherlis Neni , Kirin Arwansyah
Published: February 2024

This writing aims to analyze the occurrence of changes in the understanding of the community and the shift in language of some recitations of the Quran and Hadith from the perspective of Islamic jurisprudence (fiqh). Understanding religion cannot be separated from the issue of language shift because the fundamental sources of Islamic teachings are the Quran and Hadith, both of which are in Arabic. The translation of verses from the Quran and Hadith into the Indonesian language is not without uncertainties. For example, the change in understanding of the word "telapak tangan" (palm of the hand) as a translation of the Arabic term "kaff," which excludes the back part of the palm, leading to difficulties in practice. This study is a literature review, and data collection and analysis were conducted using this method. Changes in the community's understanding of these words can be observed in the everyday practices of the community (observation). The results of the study indicate that one of the changes in the community's understanding is the shift from the term "kaff" to "telapak tangan." Its influence can be seen in the understanding and application of the boundaries of the female aurah (parts to be covered) and the attire during ihram. Based on Hadith, most people consider the boundaries of a woman's aurah to be everything except the face and both palms. In fiqh, it is mentioned that a woman in ihram is prohibited from covering her face and both palms. This understanding and practice differ from what is intended in the Hadith and fiqh texts.
Determinants Of The VAT Gap In The European Union: An Empirical Evidence with Corruption Control As A Moderating Variable
Authors: Wijaya Suparna , Surbakti Sinarta Putra P.
Published: February 2024

The aim of this study was to determine the effect of Shadow Economy, Economic Growth, Trade Openness, and Corruption Control on VAT Gap. Additionally, this study aims to examine the moderating effect of Corruption Control on the relationship between independent variables and the dependent variable. The study was conducted using panel data regression with Panel-Corrected Standard Errors (PCSE) model in 25 European Union countries for the 2003-2020 period. The research findings indicate that all independent variables simultaneously have a significant impact on VAT Gap. Partially, Shadow Economy has a positive effect on VAT Gap, while Economic Growth has a negative effect on VAT Gap. However, Trade Openness and Corruption Control do not significantly affect VAT Gap. Corruption Control only moderates the relationship between Shadow Economy and VAT Gap negatively. This suggests that effective corruption control measures in EU countries can reduce the negative impact of Shadow Economy on VAT revenue. Based on this research, policymakers are expected to implement comprehensive monitoring and auditing practices, simplify business regulations, and enhance education and support to mitigate the potential loss of value-added tax (VAT).