bluuebunny/crossref_metadata_2025 huggingface dataset:
Microgeography and the Direction of Inventive Activity
Authors: Catalini Christian
Published: July 2017

I provide novel empirical evidence grounded in an original theoretical framework to explain why colocation matters for the rate, direction, and quality of scientific collaboration. To address endogeneity concerns due to selection into colocation and matching, I exploit the constraints imposed on the spatial allocation of labs on the Jussieu campus of Paris by the removal of asbestos from its buildings. Consistent with search costs constituting a major friction to collaboration, colocation increases the likelihood of joint research by 3.5 times, an effect that is mostly driven by lab pairs that face higher search costs ex ante. Furthermore, separation does not negatively affect collaboration between previously colocated labs. However, while colocated labs grow increasingly similar in topics and literature cited, separated ones embark on less correlated research trajectories. Research outcomes, instead, seem to be mostly influenced by how distance affects execution costs: after colocation, labs are more likely to pursue both lower-quality projects (a selection effect) and high-quality projects (an effort effect). Opposite effects on quality are observed after separation. Whereas search costs affect which scientists are likely to collaborate together, execution costs shape the quality of their output.

The online appendix is available at https://doi.org/10.1287/mnsc.2017.2798 .

This paper was accepted by Ashish Arora, entrepreneurship and innovation.
A place to rest honeyed heads
Authors: Francis-Pester Dawn
Published: July 2017

With around 240 species of wild bees in the UK, bee hotels can expect a busy season. We give you an overview of the different species and help you decide on your grand design.
P is for those pimply Papilla…
Authors: Hammond Paula , Lillie Stephen
Published: July 2017

This month, we continue our series that takes the form of an extended alphabetical adventure around the body, helping children to get to know themselves a little better.
The nature of care and respect
Authors: Garner Lynne
Published: July 2017

Those who work in the foundation stage sector will teach core British values, but how many have heard of what are known as the five freedoms, concerning animal welfare?
Science: Questioning and inquiry
Authors: Sargent Marianne
Published: July 2017

This is the fourth in a series of extracts from the book, Developing Early Science Skills Outdoors, which explores ideas for providing children with opportunities to learn outside.
Research roundup: July 2017
Authors: Lally Sheila , Thurtle Val , Murray Joy
Published: July 2017

In this section, a range of brief synopses of recently published articles that may be of interest to health visitors is presented. The aim of this roundup is to provide an overview, rather than a detailed summary, of the research papers selected. Should you wish to look at any of the papers in more detail, a full reference is provided.
Newly qualified health visitor: Raising the profile
Authors: Dobson Amy
Published: July 2017

Amy Dobson reflects on clients' perceptions of (and misconceptions about) the health visitor role. Does anyone actually know what health visitors do?
Should health visitors have a regular rotation in A&E?
Authors: Halnan Bridget
Published: July 2017

Bridget Halnan considers whether deploying health visitors' skills in A&E would contribute to better outcomes for the health and care of the local population.
Impact of early intervention on school readiness: Lessons learnt from an inner-city primary school
Authors: Besford Rebekah
Published: July 2017

This research project examined the impact of early interventions in an inner-city primary school for children's readiness for learning, and explored the need for health visiting services and early years education providers to work together. The research took a case study approach and used semi-structured interviews as the main data collection method. Seven participants in total were interviewed. The results were examined by thematic analysis. This information was compared with the school's own data of children's progress and attainment in nursery. The results show that children from socially and economically disadvantaged backgrounds can be given a better start through two channels: partnership working; and a solution-focused approach to improving school readiness. These contribute to a better start by facilitating secure attachments with the primary caregiver and through parents learning to model responsive parenting.
Scams, fraud and safety
Authors: Hanley Jane
Published: July 2017

The recent alarming reports on cyber attacks on the world's computers has prompted many of us to consider our own personal computer security, says Jane Hanley.
Synthetic Circulating Cell-free DNA as Quality Control Materials for Somatic Mutation Detection in Liquid Biopsy for Cancer
Authors: Zhang Rui , Peng Rongxue , Li Ziyang , Gao Peng , Jia Shiyu , Yang Xin , Ding Jiansheng , Han Yanxi , Xie Jiehong , Li Jinming
Published: July 2017

BACKGROUND

Detection of somatic genomic alterations in tumor-derived cell-free DNA (cfDNA) in the plasma is challenging owing to the low concentrations of cfDNA, variable detection methods, and complex workflows. Moreover, no proper quality control materials are available currently.

METHODS

We developed a set of synthetic cfDNA quality control materials (SCQCMs) containing spike-in cfDNA on the basis of micrococcal nuclease digestion carrying somatic mutations as simulated cfDNA and matched genomic DNA as genetic background to emulate paired tumor-normal samples in real clinical tests. Site-directed mutagenesis DNA that contained 1500–2000 bases with single-nucleotide variants or indels and genomic DNA from CRISPR/Cas9 edited cells with EML4-ALK rearrangements was fragmented, quantified, and added into micrococcal nuclease-digested DNA derived from HEK293T cells. To prove their suitability, the SCQCMs were compared with patient-derived plasma samples and validated in a collaborative study that encompassed 11 laboratories.

RESULTS

The results of SCQCM analysis by next-generation sequencing showed strong agreement with those of patient-derived plasma samples, including the size profile of cfDNA and the quality control metrics of the sequencing data. More than 95% of laboratories correctly detected the SCQCMs with EGFR T790M, L858R, KRAS G12D, and a deletion in exon 19, as well as with EML4-ALK variant 2.

CONCLUSIONS

The SCQCMs were successfully applied in a broad range of settings, methodologies, and informatics techniques. We conclude that SCQCMs can be used as optimal quality controls in test performance assessments for circulating tumor DNA somatic mutation detection.
Modernidad y tipología
Authors: Collado Dra. Arq. Adriana
Published: July 2017

Este trabajo surgió de un seminario de posgrado cursado en la FADU-UNL, donde se discutió si las composiciones de los trazados reguladores corbusieranos  o la recurrencia a soluciones prototípicas en la vivienda en serie, constituían manipulaciones tipologistas, apareciendo el interrogante acerca de cómo estas operaciones se articulaban con las lógicas proyectuales propias de la modernidad. Esta idea detonó una indagación, que más tarde se profundizó a través de un seminario que la autora lleva adelante en la misma facultad desde 2004, respecto de la pertinencia de encuadrar a Le Corbusier como tipologista. El objetivo de este trabajo estuvo centrado en verificar la posibilidad y riqueza que puede presentar el concepto de tipo para analizar la obra de Le Corbusier, mostrando las alusiones explícitas o implícitas al concepto realizadas por la historiografía o la crítica e indagando en la producción teórica del propio Le Corbusier, la aproximación a este concepto.
Dieste Ex Machina. Interpretación del patrimonio a través de la fabricación digital
Authors: García Amen Mg. Arq. Fernando , Payssé Álvarez Arq. Marcelo
Published: July 2017

El cometido esencial de esta publicación es proponer una reflexión acerca de la obra del Ing. Eladio Dieste desde la óptica de la fabricación digital. Esto es, interpretar el patrimonio a través de una lectura crítica de los modos de producción empleados por el autor tomando como base la fabricación digital de un modelo a escala 1:20 de la Capilla Cristo Obrero, con el propósito de promover la generación de nuevas lecturas de una obra emblemática e innovadora para su época, que pervive hasta hoy.
Bagian Depan Reaktor Vol 17 No. 2 Juni 2017
Authors: Widayat W
Published: July 2017

berisi cover, daftar isi, redaksional
블리스심볼 인식도에 대한 문화언어간 비교연구 : 한국어와 영어사용자 중심으로
Authors: Chae Soojung ,   Korean Society of Augmentative and Alternative Communication
Published: July 2017

Background and Objectives: This study explores whether there are differences in perceiving 90 randomly-selected Blissymbols across cultures. Method: 37 Korean students in Korea, 31 Korean students in the United States (U.S.), and 30 European-American students participated in this study. The data were collected from the participants’ classrooms. Materials were made in Korean and English versions and instruction of rating procedures were offered using each group's native language. Results: There was a difference for the nine individual symbols on translucency ratings for 90 Blissymbols. However, there was no difference in the overall comparisons. Conclusion: The influence of acculturation on symbol perception with people in their culture and people with acculturation experience are discussed, and implications for further research and clinical practices are suggested.
A Usability Testing of MyTalkie for Non-verbal Children with Disorders
Authors: Kim Jeongyoun , Hong Ki-Hyung ,   Korean Society of Augmentative and Alternative Communication
Published: July 2017

Background and Objectives: To propose the further research direction on optimal user-oriented AAC systems for non-verbal children, this research evaluates the usability of a convenient AAC system, MyTalkie, and especially focuses on its user interface. Method: 47 special education experts participated in the research. They have experience in teaching non-verbal children with disorders Research materials were collected and analyzed through an evaluation process, which contained an individual evaluation with a checklist rating, as well as a group discussion among experts. Results: The total average score of the usability tests was 4.06. The suitability of developing the AAC system had the highest score, while the scores on the technical characteristics of the system was relatively low. Group discussion revealed that an optimal user-oriented AAC system should support an easy and transparent way to access its information, should be suitable and consistent in very different real-use conditions, should follow standards on AAC, and should preserve errors. Conclusion: The usability test for the AAC system should be conducted gradually and repetitively, not only in the initial stage of development, but during all development stages.
Study on Perception and Need of Intervention Service Using Augmentative and Alternative Communication Device
Authors: Kim Kyung Yang ,   Korean Society of Augmentative and Alternative Communication
Published: July 2017

Background and Objectives: This study investigates the perception and needs of intervention services for AAC devices in preparation for implementation, as part of the Ministry of Welfare’s social services program. Methods: Quantitative research was conducted through questionnaires. Results: The respondents were the majority of the treatment room representatives, and most of them did not know whether they had heard about AAC. However, there was a high demand for AAC intervention services and a high response rate to retraining. Conclusions: There was a high demand for intervention services for the use of AAC devices in the field. Retraining as an AAC expert should also be considered. The recent trends in AAC devices and the need for training in diagnosis evaluation and intervention were high for reeducation. Discussions and suggestions are presented.
Führt das autonome Fahrzeug zu mehr Sicherheit und Effizienz im
Straßenverkehr?
Authors: Zimmer Alf C.
Published: July 2017

Die Versprechen einer Vollautomatisierung des Individualverkehrs werden analysiert
und es wird gezeigt, dass ein derart komlexes System hochgradig fragil ist und daher
wahrscheinlich weder hinsichtlich Sicherheit noch hinsichtlich Effizient die Leistung
erbringen kann, die durch hybride Mensch-Maschine-Systeme erreicht werden können.
Es wird insbesondere auf die Übernahme-Problematik z. B. von Autopilot auf manuelle
Steuerung verwiesen. Als konzeptueller Ansatz für ein solches System kann die der Feld-theoretische Ansatz
von Gibson & Crooks genommen werden.
Von der Rennstrecke auf die Straße
Authors: Siedersberger Karl-Heinz
Published: July 2017

Innovationen entstehen oftmals auf der Rennstrecke. Damit daraus kundenwerte Produkte werden, bedarf es weiterer
Entwicklungsmaßnahmen und Tests. Dies betrifft im besonderen Maße Fahrerassistenzsysteme, die per se einer
intensiven Interaktion zwischen Fahrer und System unterliegen. Anhand eines für die Rennstrecke entwickelten
Fahrdynamikreglers für das fahrerlose Fahren wird gezeigt, wie dieser unter Nutzung von Ergebnissen zur Auslegung der
Mensch-Maschine-Schnittstelle für das automatische Ausweichen adaptiert wurde.
Parent reported nutritional risk and laboratory indices of cardiometabolic risk and in preschool-aged children
Authors: Persaud Navindra , Ziai Hedyeh , Lebovic Gerald , Maguire Jonathon L. , Khovratovich Marina , Simpson Janis A. Randall , Adeli Khosrow , Hamilton Jill , McCrindle Brian W. , Parkin Patricia C. , Birken Catherine S.
Published: July 2017

Background:

Eating habits formed during childhood may contribute to the increasing prevalence of cardiometabolic disorders. Assessing nutritional risk in young children may help to prevent later cardiometabolic disease. The objective of this study was to determine whether parent-reported nutritional risk in preschool-aged children was associated with laboratory indices of cardiometabolic risk, namely leptin and insulin.

Methods:

In this cross-sectional study, the relationship between nutritional risk as determined by the parent-completed NutriSTEP

Results:

The total NutriSTEP

Conclusions:

Parent reported nutritional risk is associated with serum leptin, but not insulin, concentrations in preschool-aged children. The NutriSTEP
Electrochemotherapy – supplementary treatment for loco-regional metastasized breast carcinoma administered to concomitant systemic therapy
Authors: Grischke Eva-Maria , Röhm Carmen , Stauß Eva , Taran Florin-Andrei , Brucker Sara Y. , Wallwiener Diethelm
Published: July 2017

Background

Electrochemotherapy (ECT) is an established procedure for treating breast cancer loco-regional recurrences following surgical intervention and/or radiotherapy. Limited information is available on ECT application as a concomitant procedure to systemic therapy in recurrent breast cancer. The primary objective of this study was to determine if the application of ECT in close temporal relation to systemic chemotherapy could lead to increased local and/or systemic side effects. For this purpose we evaluated the safety of ECT as a supplemental local therapy to systemic therapy. ECT local and systemic toxicity and side effects were recorded and whether the anticipated local therapeutic effect of ECT would be influenced by the concomitant use of systemic therapies was investigated.

Patients and methods

This is an observational study. Thirty three patients with loco-regional metastasized breast carcinoma were treated and observed over a period of three years with 46 ECT applications for local tumour control in addition to established systemic therapy. A specific timeline for ECT administration was not fixed up, but was generally performed one week before the following chemotherapy administration with the aim to avoid the so called nadir, this means the peak period with risk of neutropenia.

Results

Data was collected over a period of three years on a population of 33 metastatic patients. Fifteen patients, received neo-adjuvant therapy as part of their primary treatment, but still had an advanced stage tumour. Some patients received repeated ECT applications. Objective tumour response was observed in 90% of the treated patients. Patients showed no increased local toxicity, especially no higher dermal toxicity, e.g. formation of local necrosis.

Conclusions

ECT proved to be an effective supplement to a cytotoxic systemic therapy, especially for high-risk patients who did not respond well to systemic therapy of loco-regional metastases, without creating any greater systemic or loco-regional toxicities.
Selection of non-small cell lung cancer patients for intercalated chemotherapy and tyrosine kinase inhibitors
Authors: Zwitter Matjaz , Rossi Antonio , Di Maio Massimo , Perme Maja Pohar , Lopes Gilberto
Published: July 2017

Background

When treating patients with advanced non-small cell lung cancer (NSCLC) with tyrosine kinase inhibitors and chemotherapy, intercalated schedule with time separation between the two classes of drugs should avoid their mutual antagonism. In a survey of published trials, we focus on relation between eligibility criteria and effectiveness of intercalated treatment.

Methods

Published documents were identified using major medical databases, conference proceedings and references of published trials. Median progression-free survival (PFS) was taken as the basic parameter of treatment efficacy. Correlation between characteristics of patients and median PFS was assessed through the Pearson’s correlation coefficient and the coefficient of determination, separately for first-line and second-line setting.

Results

The series includes 11 single-arm trials and 18 randomized phase II or phase III trials with a total of 2903 patients. Treatment-naive patients or those in progression after first-line treatment were included in 16 and 13 trials, respectively. In 14 trials, only patients with non-squamous histology were eligible. Proportion of patients with non-squamous carcinoma (in first-line setting), proportion of never-smokers (both in first- and second-line setting) and proportion of epidermal growth factor receptor (EGFR) mutant patients (both in first- and second-line setting) showed a moderate or strong correlation with median PFS. In six trials of intercalated treatment applied to treatment-naive EGFR-mutant patients, objective response was confirmed in 83.1% of cases and median PFS was 18.6 months.

Conclusions

Most suitable candidates for intercalated treatment are treatment-naive patients with EGFR-mutant tumors, as determined from biopsy or liquid biopsy. For these patients, experience with intercalated treatment is most promising and randomized trials with comparison to the best standard treatment are warranted.
The German Occupation Regimes in Southeastern Europe as a Research Problem in Yugoslav and Serbian Historiography
Authors: Ristović Milan
Published: July 2017

The author revisits works produced during the time of socialist Yugoslavia to assess the historiographical literature on the German occupation regimes there. He concludes that since Yugoslavia’s demise there has been hardly any evolution towards a more solid nor more differentiated historiography such as would meet international standards. To be sure, significant new research has been produced, but it has been hampered by the narrow and often difficult academic frameworks that have existed in the last twenty-five years. Scholars have been expected to respond to the new nationalized agendas of the successor states, and have seen few structural incentives to link their work to international research networks, or to the work of their colleagues in neighbouring countries. The author’s focus is the German occupation of Serbia, but he includes some examples of scholars whose focus is German-occupied Slovenia, or the Independent State of Croatia, and he keeps in perspective the wider (Southeast) European contexts.
Holocaust Research in Croatia, Bosnia and Herzegovina, and Serbia. An Inventory
Authors: Vulesica Marija
Published: July 2017

The Holocaust and other mass killings committed during the Second World War in the Yugoslav territories play a more significant role in current public debates than they do in education and research. 85% of Yugoslavia’s Jews were annihilated in the period between 1941 and 1945. In socialist Yugoslavia, it was Holocaust survivors in particular who collected materials that documented the execution of exterminist policies. How has the examination of the Holocaust changed since the dissolution of Yugoslavia; and how have the newly established states of Croatia, Bosnia and Herzegovina, as well as Serbia coped with this part of their history? The author asks whether an exclusive exploration of Jewish suffering is possible—or even desirable—in today’s post-Yugoslav societies. She gives an overview of the evolution of a specific ‘Yugoslav’ approach to the history of the Holocaust, and depicts recent Croatian, Bosnian, and Serbian efforts in this field. Furthermore, she looks at what kind of attention the Holocaust in Yugoslavia has received in international Holocaust Studies.
Investigation of the effect of cornelian cherry (Cornus mas L.) fruit extract against cisplatin-induced renal cell injury in vitro
Authors: Yarim Gul Fatma , Kazak Filiz , Sozmen Mahmut , Koca Ilkay , Albayrak Harun , Yarim Murat , Cenesiz Sena , Ozan Emre
Published: July 2017

Objective

The aim of this study was to evaluate the protective effects of cornelian cherry fruit extract against cisplatin-induced nephrotoxicity in vitro.

Materials and methods

African green monkey kidney epithelial cells (Vero) were incubated with 100 mg/mL of cornelian cherry fruit extract, 50 μmol/L of cisplatin or 50 μmol/L of cisplatin plus 100 mg/mL of cornelian cherry fruit extract for 4 h. The wells containing cells without any supplementation served as control. Cell viability was determined by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazoliumbromide assay. Culture mediums were collected, centrifuged and analyzed for malondialdehyde (MDA), glutathione (GSH), superoxide dismutase (SOD) and glutathione peroxidase (GPx).

Results

The cell viability was 59% in cells co-treated with cisplatin and cornelian cherry fruit extract simultaneously and 42% in cisplatin treated cells. The cellular damage ratio was elevated in cells treated with cisplatin. However, when cisplatin combined with cornelian cherry fruit extract the deleterious effects of cisplatin were significantly decreased. The MDA concentration was significantly higher (p<0.05), GSH concentration and GPx and SOD activities were significantly lower (p<0.05) in cisplatin treated group when compared with control group, cornelian cherry group, and cisplatin+cornelian cherry group.

Conclusion

The present study indicated that cornelian cherry fruit extract exert protective effects on oxidative damage in vitro induced by cisplatin.
Syntheses of benzo[c]coumarin carboxylic acids and fluorescence properties in the solid state
Authors: Shi Juan , Liang Yong , Zhang ZunTing
Published: July 2017

7-Hydroxy-3-methoxy-6-oxo-6H-benzo[c]- chromene-8-carboxylic acid (3a), 3,7-dihydroxy-6-oxo-6H- benzo[c]chromene-8-carboxylic acid (3b), 1,7-dihydroxy-6-oxo-6H-benzo[c]chromene-8-carboxylic acid (3c) and 2-bromo-7-hydroxy-6-oxo-6H-benzo[c]chromene-8-carboxylic acid (3d) were synthesized and characterized by the method of single crystal X-ray diffraction. Owing to bigger conjugated system and various H-bonds in 7-hydroxy-6-oxo-6H-benzo[c]chromene-8-carboxylic skeleton, 3a–3c have excellent fluorescence in ethanol solution and the solid state. The synthons involved in each crystal are identified, and the fluorescence emission differences leading to molecular recognition are determined.
Structural investigation and Hirshfeld surface analysis of three organic picrate salts
Authors: Loh Wan-Sin , Kwong Huey Chong , Kumar C.S. Chidan , Quah Ching Kheng
Published: July 2017

Three picrate salt crystals, namely 5-amino-6-methylquinolin-1-ium 2,4,6-trinitrophenolate (I), 3-phenyl-1H-pyrazol-2-ium 2,4,6-trinitrophenolate (II) and 1H-imidazol-3-ium 2,4,6-trinitrophenolate (III) were characterized by X-ray diffraction. Salt I crystallizes in space group of P21/c, with a=15.096(2), b=7.2864(9), c=15.248(2) Å, β=98.437(2)°, V=1659.1 Å3 and Z=4. Salt II crystallizes in monoclinic space group P21/c, with a=13.6230(9), b=6.7421(5), c=17.7508(12) Å, β=106.001(1)°, V=1567.20 Å3 and Z=4. Whereas salt III crystallizes in triclinic system, space group P1̅, with a=7.6919(10), b=7.9218(10), c=10.2230(13) Å, α=81.909(2), β=77.985(2), γ=82.629(2)°, V=600.05 Å3 and Z=2. Protons were transferred from the picric acids to their corresponding bases, forming intermolecular N+–H···O− hydrogen bonds in the three salts. Salts I and II form planes, whereas salt III forms chains via N–H···O and C–H···O hydrogen bonds as their supramolecular assembly. Planes and chains in all these salts were interconnected through π···π interaction. The intermolecular interactions in the crystal structures were quantified and were analysed using Hirshfeld surface analysis.
Vector Dark Solitons for a Coupled Nonlinear Schrödinger System with Variable Coefficients in an Inhomogeneous Optical Fibre
Authors: Liu Lei , Tian Bo , Wu Xiao-Yu , Yuan Yu-Qiang
Published: July 2017

Studied in this paper are the vector dark solitons for a coupled nonlinear Schrödinger system with variable coefficients, which can be used to describe the pulse simultaneous propagation of theM-field components in an inhomogeneous optical fibre, whereMis a positive integer. WhenM=2, under the integrable constraint, we construct the nondegenerateN-dark-dark soliton solutions in terms of the Gramian through the Kadomtsev–Petviashvili hierarchy reduction. With the help of analytic analysis, a vector one soliton with varying amplitude and velocity is studied. Interactions and bound states between the two solitons under different group velocity dispersion and amplification/absorption coefficients are presented. Moreover, we extend our analysis to anyMto obtain the nondegenerate vectorN-dark soliton solutions.
Improving Post-graduate Students Learning Activities through Lesson Study in Learning Forest-Prototype
Authors: Muhfahroyin Muhfahroyin , Oka Anak Agung
Published: July 2017

Improving learning quality in 21st can not be separated from contextual learning and student-centered learning paradigm. Through the contextual lesson study program conducted in learning-forest prototype to build learning community. The objectives of this research were to improve learning activities of postgraduate students in Biology Education department and to build a learning community. The implementation of lesson study was conducted in the Biology Learning Innovation subject for postgraduate students while practicing to observe open lesson was conducted in the undergraduate students which used learning forest-prototype. The postgraduate students took roles as planner, observer, and reflector in the plan, do (open lesson), and see (reflection) activities. The lesson study implementation was conducted for three cycles in even semester of academic year 2015/2016. Students learned collaboratively and contextually. The postgraduate students’ learning activities were observed by six observers from lecturer colleagues. The research results showed that the students were able to implement planning, open lesson, and reflection properly. The average of student’s learning activity grade was 91.11% from all of students, with the grade averages for planning, open lesson, and reflection activities were 88.89%, 93.33%, and 91.11% respectively. The implementation of this lesson study in the learning forest-prototype can be done in other relevant subjects to strengthen learning activities.
Characterization of Ethanolic Extract of Streptomyces sp. As a Pancreatic Lipase Inhibitors Produced by Endophytic Streptomyces sp. AEBg12
Authors: Fitri Lenni , Meryandini Anja , Iswantini Dyah , Lestari Yulin
Published: July 2017

Endophytic Streptomyces sp. AEBg12 isolated from Zingiber cassumunar (Bangle) is known to produce pancreatic lipase inhibitory compound. However, the characteristics of this active compound has not been reported yet. This study aimed to determine the characteristics of pancreatics inhibitory compound produced by Streptomyces sp. AEBg12 and to assess the role of endophytic actinobacteria in producing pancreatic lipase inhibitor using endophytic-free bangle tissue culture, wild bangle and compared with the activity of Streptomyces sp. AEBg12 endophytes. Supernatant of Streptomyces sp. AEBg12 was extracted using ethanol, ethyl acetate, and n-hexane solvents. Toxicity test was performed using larvae of shrimp Artemia salina. The results showed that the best solvent to obtain pancreatic lipase inhibitor compounds was ethanol. Phytochemical analysis showed that ethanolic extract of endophytic Streptomyces sp. AEBg12 contained flavonoids. IC50 value of ethanol extract was 180.83 µg/ml. The result of TLC showed that ethanolic extract of Streptomyces AEBg12 had a blue luminescence band indicated that there were either flavone, flavanones, flavonols or isoflavones. Inhibitory activity of Streptomyces sp. AEBg12 was higher than wild bangle and bangle tissue culture. The benefit of this study was to obtain new compound which might be used as an antiobesity drug through approach to the pancreatic lipase inhibitor.
Characterization of The Interaction Between RIN13 (RPM1-Interacting13) and Sumo Proteins in Arabidopsis Thaliana
Authors: Santosa Venny , Nagabuchi Mio , Okada Sachiko , Tanaka Katsunori
Published: July 2017

Small Ubiquitin-related MOdifier (SUMO) proteins can be found in many organisms, including A. thaliana, which possesses 9 SUMO genes. SUMO binds to various target proteins in a reversible reaction called SUMOylation. SUMOylation participates in transcription, chromosome organization, proteins localizations and stress responses. Our study showed that RIN13 (RPM1-Interacting13/At2g20310) is a target of SUMOylation, which was initially found by interaction between this protein and AtSCE1a (E2). Recent report showed that overexpression of RIN13 enhanced the resistance to pathogen without inducing hypersensitive response. However, the molecular interaction between RIN13 and SUMO proteins and its significance have not been studied yet. Thus, our study aimed to characterize the interaction between RIN13 and SUMO proteins in A. thaliana. The result showed an isoform-specific SUMOylation between RIN13 and SUMO proteins. RIN13 is SUMOylated by SUMO1, 2, 3, and 5. Though expressed ubiquitously in A.thaliana, fluorescence microscopy showed that RIN13 localizes subcellularly in the nuclear body. Moreover, complete abolishment of SUMOylation with inactive E2 suggests the exclusion of RIN13 from nuclear body. These results showed that SUMOylation affected RIN13 localization, and indirectly influenced its interaction to other proteins and putative function. This paper presents evidence of RIN13 SUMOylation. Furthermore, RIN13 function in pathogenic resistance is shown to be supported by SUMOylation. Thus, this study enhanced the understanding of SUMO in plants and served as reference to molecular studies concerning post-translational modification of SUMO.
Transcription controls growth, cell kinetics and cholesterol supply to sustain ACTH responses
Authors: Menzies Robert I , Zhao Xin , Mullins Linda J , Mullins John J , Cairns Carolynn , Wrobel Nicola , Dunbar Donald R , Bailey Matthew A , Kenyon Christopher J
Published: July 2017

Chronic ACTH exposure is associated with adrenal hypertrophy and steroidogenesis. The underlying molecular processes in mice have been analysed by microarray, histological and immunohistochemical techniques. Synacthen infused for 2 weeks markedly increased adrenal mass and plasma corticosterone levels. Microarray analysis found greater than 2-fold changes in expression of 928 genes (P < 0.001; 397 up, 531 down). These clustered in pathways involved in signalling, sterol/lipid metabolism, cell proliferation/hypertrophy and apoptosis. Signalling genes included some implicated in adrenal adenomas but also upregulated genes associated with cyclic AMP and downregulated genes associated with aldosterone synthesis. Sterol metabolism genes were those promoting cholesterol supply (Scarb1, Sqle, Apoa1) and disposal (Cyp27a1, Cyp7b1). Oil red O staining showed lipid depletion consistent with reduced expression of genes involved in lipid synthesis. Genes involved in steroidogenesis (Star, Cyp11a1, Cyp11b1) were modestly affected (P < 0.05; <1.3-fold). Increased Ki67, Ccna2, Ccnb2 and Tk1 expression complemented immunohistochemical evidence of a 3-fold change in cell proliferation. Growth arrest genes, Cdkn1a and Cdkn1c, which are known to be active in hypertrophied cells, were increased >4-fold and cross-sectional area of fasciculata cells was 2-fold greater. In contrast, genes associated with apoptosis (eg Casp12, Clu,) were downregulated and apoptotic cells (Tunel staining) were fewer (P < 0.001) and more widely distributed throughout the cortex. In summary, long-term steroidogenesis with ACTH excess is sustained by genes controlling cholesterol supply and adrenal mass. ACTH effects on adrenal morphology and genes controlling cell hypertrophy, proliferation and apoptosis suggest the involvement of different cell types and separate molecular pathways.
Influences of manganese on pubertal development
Authors: Dees William L , Hiney Jill K , Srivastava Vinod K
Published: July 2017

The onset of puberty is the result of complex neuroendocrine interactions within hypothalamic region of the brain, as well as from genetic and environmental influences. These interactions ultimately result in the increased synthesis and release of luteinizing hormone-releasing hormone (LHRH). Manganese (Mn) is an essential environmental element known for years to be involved in numerous mammalian physiological processes, including growth and reproductive function. Studies in recent years have shown the ability of Mn to cross the blood–brain barrier and act within the hypothalamus to influence the timing of puberty. This review will depict research showing the molecular and physiological actions of Mn in the control of prepubertal LHRH and discuss the potential for the element to cause either helpful or harmful outcomes on the developmental process depending upon the age and accumulation of Mn within the hypothalamus.
480 minutos de trabajo por 15 minutos de ocio
Authors: Reyes Rivera Mabir Lubieth
Published: July 2017

Desde mucho antes de la época conocida como Revolución Industrial, existían trabajadores asalariados que cumplían horarios y vendían su fuerza de trabajo. De la misma manera se evidencia en la historia escrita las diversas luchas obreras que surgen a partir de la indignación de éste gremio por falta de condiciones dignas, aumento salarial y tiempo libre que aunque, no producía remuneración alguna, sí se sentía como necesario para la recuperación física y mental luego de las largas jornadas de trabajo. En nuestra época, el trabajador asalariado y operario, luego de años de lucha, no obtiene ese tiempo de ocio que ayude a su recuperación emocional, física y mental. En éste punto, empieza a hacerse visible que las limitaciones no son solo las generadas por los empleadores o del sistema (aunque definitivamente el modelo capitalista industrializado se instaló con intenciones de no irse nunca), sino también las creadas por el mismo empleado, que no concibe aún la importancia de un tiempo de ocio por encima del trabajo, de la producción y del mismo dinero.
El texto se divide en tres partes: la primera, dedicada al proceso de lucha obrera de la revolución industrial, que reconoce las razones del origen de la indignación demostrada por los trabajadores; la segunda, se dedica a la mirada de otros autores y estudiosos del ocio que se han enamorado de ésta visión de desarrollo humano y la última parte denota una idea de investigación con una población operaria en la actualidad.
Effect of Different Silane Treatments on Long-Term Bonding Between Non-Etched Glass-Ceramic and Resin Cement
Authors: Murillo Gómez DDS, MSc Fabián , De Goes DDS, MSc, PhD Mario F.
Published: July 2017

The present study evaluated the bond strength between glass-ceramic and resin cement, using different silane treatments, performing no previous hydrofluoric acid (HF) etching on ceramic surface, after short- and long- term storage. One hundred and eighty glass-ceramic plaques (IPS e.max CAD®) were polished and divided into six groups (n=30) to receive different silane treatments: (1) RCP-RelyX Ceramic Primer® (one-bottle silane), (2) RCP+SB-RelyX Ceramic Primer and Adper Singlebond2® (silane plus separated adhesive), (3) SBU-Scotchbond Universal® (silane-containing universal adhesive), (4) CP-Clearfil Ceramic Primer® (silane/MDP primer), (5) NC-no-silane (negative control) and (6) PC-Previous HF etching (5%, 20s) plus RelyX Ceramic Primer® (positive control). Two resin cement cylinders (Rely X Ultimate®) were built on each plaque. Each group was divided into two sub-groups to be stored for 24 hours (24h) or 6 months (6mo) in distilled water at 37°C (n=15). Then microshear (µSBS) testing was performed. Failure mode was analyzed using scanning electron microscopy (SEM). Data were statistically analyzed by two-way ANOVA and Tukey´s test (α=0.05). Both factors and their interaction resulted statistically significant (p≤0.05). PC obtained the highest µSBS values (in MPa) at both storage times (24h: 28.11±2.44; 6mo: 19.10±3.85). After 24h storage, groups RCP+SB (10.86±3.62), SBU (8.37±4.33) and CP (8.05±3.62) were not statistically different from NC (8.00±2.51); only RCP (19.73±4.63) and PC obtained higher values. After 6 months, only PC showed higher values than NC (0.04±0.01). Cohesive failure in resin cement was more prevalent for RCP-24h and PC, while adhesive failure was more frequent among all other groups.  Clinical relevance: None of the commercially available silane primers tested, improve long- term ceramic/cement bonding without performing HF etching on ceramic surface. Combination of HF acid and silane, remain as a gold standard treatment for glass-ceramic materials.
Treatment with Ortognactic Surgery in Patient Class III Skeletal with Lateral Left Mandibular Deviation. Case Report
Authors: Ubilla Mazzini DDS, Esp William , Sánchez Laguna DDS, Esp Manuel , Mazzini Torres DDS, MSc Fátima , Moreira Campuzano DDS, Esp Tanya
Published: July 2017

Class III malocclusion is one of the most complex to treat for healthcare because it presents alterations in skeletal and dental component of patients. Case Report: male patient, 17 years old, had a skeletal Class III malocclusion with mandibular prognathism, facial asymmetry, plus a slightly concave profile, crossbite and posterior left. By orthognathic surgery, using the technique of sagittal ramus osteotomy and segmentation maxillary, Le Fort I, malocclusion, accompanied by the Alexander technique Orthodontics is corrected. Conclusion: the correct application of knowledge in the field of Orthodontics and Maxillofacial Surgery allows patients to become skeletal class II to cephalometric analysis, changes to your profile slightly convex and canine class I is reached on both sides.
„weil die Texte oft mehr beachtet werden als die Musik“ Zur Relevanz und Verlässlichkeit kompositorischer Selbstauskünfte am Beispiel György Ligetis
Authors: Marx Wolfgang
Published: July 2017

This essay identifies three reasons that help explain why György Ligeti was highly active as a speaker and author of texts about music throughout his career. He thereby replenished his income (particularly before 1973), asserted his auctorial authority vis-à-vis musicological interpretations and — at least indirectly — secured a better “share of the market” for his own music by being present in the public eye. This essay also discusses the reliability of Ligeti’s assertions which warned against an overreliance on composers’ views on the part of musicologists.
Eliminieren und Evozieren. Einige Anmerkungen zum Sprechen über György Ligetis Atmosphères
Authors: Heimerdinger Julia
Published: July 2017

This article reflects the ‘verbal history’ of György Ligeti’s most prominent work, the orchestral piece Atmosphères from 1961. It discusses previously unknown notes from the György Ligeti collection at the Paul Sacher Stiftung, Basel as well as official comments by Ligeti. In addition, it takes into account the secondary literature, beginning with Harald Kaufmann’s influential text “Strukturen im Strukturlosen” (1964), which was partly co-authored by Ligeti. The main aspects in focus are the composer’s own distinction within the contemporary music scene, his way of describing his work in terms of perception, and his handling of the concepts of effect and structure.
Der kanonisierte Ligeti
Authors: Weiss Stefan
Published: July 2017

By the middle of the 1960s, only a couple of years after his defection from Hungary to Austria and West Germany, Ligeti had already achieved canonical status in Western circles of contemporary music, even if more in German speaking countries than in English speaking ones. As a by-product of this extremely quick process, Ligeti was identified with the new musical language of ‚Klangkomposition‘ (sound-mass music) and micropolyphonic texture, an identification that has stuck with him since — the works written from 1958 to 1967, and Atmosphères in particular, remain by far his best known and most frequently cited compositions. If canonization in itself must be regarded to a certain degree as desirable to any composer, in Ligeti’s case there were unwanted effects of this development. Although the composer himself contributed to it by his writings, his early identification as a composer of sound masses not only narrowed the reception of his oeuvre but affected his later self-image as a composer, too.
Ungarn lernt Ligeti kennen: persönliche Begegnungen und kompositorische Rezeption
Authors: Dalos Anna
Published: July 2017

Hungarian composers in the past very rarely reflected on György Ligeti’s oeuvre. Concentrating on their own struggles with musical modernism and avant-garde after 1956, they considered Ligeti one of the most important Hungarian composers of their time, but didn’t really understand his concepts and techniques. My study aims at interpreting this misunderstanding through the analysis of orchestral works by Ligeti’s best Hungarian friend, András Szőllősy (1921–2007). For contemporary Hungarian musicians and critics, Szőllősy’s compositions represented the counterpart of the great émigré’s life work.
„Ein violetter Ort von blecherner Beschaffenheit und ebensolchem Klang“ Ligetis Synästhesien
Authors: Noeske Nina
Published: July 2017

The article focuses on Ligeti’s synaesthesia: after referring to some early ‘synaesthetic’ compositions often mentioned by the composer, the phenomenon of synaesthesia in general is examined. It turns out that Ligeti’s fondness of synaesthesia has to be seen in relation to his ‘postmodern’ emphasis on spatiality in music – and thereby with his attempts to overcome transitoriness and death.
Kepemimpinan untuk Mendukung Keberhasilan Implementasi Kebijakan Konservasi Sumber Daya Alam
Authors: Hartono Tjahjo Tri
Published: July 2017

Pada tahun 2020, Pemerintah Indonesia melalui Kementerian Kelautan dan Perikanan mentargetkan 20 juta hektar perairan (laut dan umum daratan) dapat ditetapkan sebagai kawasan konservasi perairan dan dikelola secara efektif. Pencapaian salah satu target pembangunan berkelanjutan di bidang kelautan dan perikanan ini perlu diperhatikan mengingat panjangnya sejarah konflik pengaturan pemanfaatan dan pengelolaan sumber daya di dalam kawasan konservasi. Untuk itu, dialog antar aktor, pihak-pihak yang berpotensi untuk berkonflik, perlu dibangun bersama sejak sebuah wilayah dicadangkan dan selanjutnya ditetapkan sebagai kawasan konservasi perairan. Efektivitas dialog, yang diindikasikan oleh berbagai hal spesifik di lapangan, membutuhkan sosok-sosok aktor yang memiliki jiwa kepemimpinan. Melalui pemenuhan 5 (lima) faktor kepemimpinan, individu tersebut akan mengupayakan kelompoknya untuk menjadi organisasi pembelajar, yaitu organisasi yang senantiasa mampu melakukan perbaikan (continuous improvement) dalam rangka mereduksi dan mengelola konflik yang mungkin timbul karena diberlakukannya pengaturan dan pengelolaan sumber daya kelautan dan perikanan yang berbasis pada prinsip-prinsip konservasi di suatu wilayah.
Decompressive craniotomy for the treatment of malignant infarction of the middle cerebral artery: mortality and outcome
Authors: Bongiorni Gianise Toboliski , Hockmuller Marjeane Cristina Jaques , Klein Cristini , Antunes Ápio Cláudio Martins
Published: July 2017

ABSTRACT Objective To assess, by Rankin scale, the functional disability of patients who had a malignant middle cerebral artery (MCA) ischemic stroke, who underwent decompressive craniotomy (DC) within the first 30 days. Methods A cross-sectional study in a University hospital. Between June 2007 and December 2014, we retrospectively analyzed the records of all patients submitted to DC due to a malignant MCA infarction. The mortality rate was defined during the hospitalization period. The modified outcome Rankin score (mRS) was measured 30 days after the procedure, for stratification of the quality of life. Results The DC mortality rate was 30% (95% CI 14.5 to 51.9) for the 20 patients reported. The mRS 30 days postoperatively was ≥ 4 [3.3 to 6] for all patients thereafter. Conclusion DC is to be considered a real alternative for the treatment of patients with a malignant ischemic MCA infarction.
The art and neurology of Paul Richer
Authors: Maranhão-Filho Péricles
Published: July 2017

ABSTRACT In the 1890s, one of Charcot’s most important protégés, Dr. Paul Richer (1849–1933), drew and sculpted a series of representations of the main types of nerve pathology. That series included drawings of pleomorphic hysterical crises and sculptures depicting patients suffering from labio-glosso-laryngeal paralysis and myopathy, as well as Parkinson’s disease. Richer was a resident at La Salpêtrière and, in 1882, became head of the Charcot museum. Early in his career, despite having no formal artistic training, he could represent masterfully, in drawings and sculptures, people’s tragic suffering from neurological diseases. Later on, with the same tools, he expressed the beauty of human movements in health.
Cranio-vertebral transition assessment by magnetic resonance imaging in a sample of a northeast Brazilian population
Authors: Frade Heitor Cabral , França Caio César Nuto Leite , Nascimento José Jailson Costa do , Holanda Maurus Marques de Almeida , Silva Neto Eulâmpio José da , Araújo Neto Severino Aires
Published: July 2017

ABSTRACT Platybasia and basilar invagination are important alterations of the cranial-vertebral transition. Neuroimaging-based platybasia parameters include the Welcker basal angle, distance between the apex of the odontoid and Chamberlain’s line, and the clivus-canal angle. This study aimed to measure and correlate these parameters in a sample from northeast Brazil. Methods Cross-sectional analysis of craniometric parameters from individuals submitted to magnetic resonance at an outpatient imaging center between 2011 and 2012. Results Of 181 analyzed cases, the Welcker basal angle averaged 128.96º (SD 6.51), median distance between apex of the odontoid and Chamberlain’s line was 2.27 mm (IQR -1.23–4.47) and the median clivus-canal angle was 150.5º (IQR 143.2–157.3). The Welcker basal angle was inversely correlated to the clivus-canal angle, and correlated to the distance between the apex of the odontoid and Chamberlain’s line. Conclusion There was a tendency to platibasia, basilar invagination and narrowing of the cranio-vertebral transition.
ASSISTÊNCIA DE ENFERMAGEM AO PACIENTE COM DISTÚRBIOS HEMATOLÓGICOS
Authors: Aguillar Olga Maimoni , Zago Márcia Maria Fontão
Published: July 2017

Este trabalho aborda considerações gerais sobre o cuidado ao paciente com distúrbios hematológicos. As autoras levantam os problemas mais comuns destes pacientes e apresentam algumas propostas para a solução dos mesmos.