bluuebunny/crossref_metadata_2025 huggingface dataset:
Potential Errors and Corrections in Early Phase Drug Development
Authors:   MedSurgPI LLC, 3700 Lark Farm Road, Franklinton, NC 27525, USA, Klein Gerald L. , Morgan Roger ,   MedSurgPI LLC, 3700 Lark Farm Road, Franklinton, NC 27525, USA
Published: January 2023

Many foreign and small companies trying to enter the United States biopharmaceutical market make avoidable errors in their early clinical phase drug development and clinical trials. They need to first understand the risks that they must endure with patent law, regulatory hurdles, the complexity and duration of the necessary clinical trials, and the large cost of drug development, which often necessitates raising substantial capital from investors. If appropriate capital for these clinical studies must be raised, then the company must be able to clearly articulate a realistic expected return on investment to these individuals. So, they must also understand the market, its exclusivity, and the competition. This must all be put together in a sleek pitch deck. Early errors frequently begin with too few, inadequate, or poorly constructed patents. These and other risks and errors may be prevented by the use of an experienced product development team. Many of these errors could be avoided if companies used more experienced drug development professionals to assist them in selecting the optimum patent strategy, regulatory plan, budget, contract research organization (CRO), clinical investigators, and etc. It is hoped that this opinion piece will help make early clinical trials more effective and save time and money.
elirium of Skin Infestation: Epidemiological and Clinical Profile of 73 Patients
Authors:   Dermatology Teaching Hospital of Bamako, Bamako, Mali and University of Sciences, Techniques and Technologies De Bamako, B. P. 251, Bamako, Mali, Dicko Adama A. , Konandji Adam ,   CHU Hospital of Dermatology of Bamako (HDB), B. P. 251, Bamako, Mali, Nkesu Yannick M. ,   CHU Hospital of Dermatology of Bamako (HDB), B. P. 251, Bamako, Mali, Tall Koreissi K. ,   CHU Hospital of Dermatology of Bamako (HDB), B. P. 251, Bamako, Mali, Guindo Binta ,   CHU Hospital of Dermatology of Bamako (HDB), B. P. 251, Bamako, Mali, Mamadou Gassama ,   CHU Hospital of Dermatology of Bamako (HDB), B. P. 251, Bamako, Mali, Karabinta Yamoussa ,   CHU Hospital of Dermatology of Bamako (HDB), B. P. 251, Bamako, Mali, Traor Aboubacrine ,   CHU Hospital of Dermatology of Bamako (HDB), B. P. 251, Bamako, Mali, Sissoko Madou ,   CHU Hospital of Dermatology of Bamako (HDB), B. P. 251, Bamako, Mali, Faye Ousmane ,   CHU Hospital of Dermatology of Bamako (HDB), B. P. 251, Bamako, Mali
Published: January 2023

Background This was a descriptive and prospective study that focused on 73 cases of delirium of skin infestation (DSI) from January 1st to December 31st, 2018, in the dermatology department of the Bamako Dermatology Hospital (HDB). Aim The aim of this work was to describe the epidemiological and clinical profile of delusions of infestation (Ekbom syndrome), to deepen our knowledge of the disease in order to improve its overall management. Methods We carried out a descriptive cross-sectional study of cases of identity document (ID) seen in dermatological consultation in the HDB dermatology department between January 1st and December 31st, 2018. Now, this department is the largest dermatological reference center in the country. In our study, we have included any patient with delirium of parasitic infestation (defined as an unshakeable conviction that small vermin, insects, lice, maggots, proliferate in the skin and sometimes in the body without biological proof). Results Delirium of skin infestation constituted 0.3% of consultations in the service. The average age was 52-years with extremes ranging from 12 to 85-years. They were 45 female (62%) and 28 male (45%). The age group (25-64) was the most represented. Out-ofschool patients represented 65% of the sample. Among them, 6 cases (8%) were known in psychiatry. The agents incriminated by the patients were mainly ants, earthworms and cicadas. The specimen sign was found in 89% of cases. Insomnia was the most frequent associated sign, at 75%. The types of lesion complications observed in our patients were mainly lichenification, ulceration and excoriation. Seventy-two percent (72%) of patients have refused referral to the mental health service. The profile of Ekbom syndrome was the one of the adult women, described in the previous work. Conclusion Delirium of skin infestation is generally considered as rare disease, increasingly observed during our dermatology consultations. Its frequency is probably underestimated.
Acute Necrotizing Dermohypodermatitis Due to an Unusual Germ: Providencia Stuartii
Authors:   CHU Hospital of Dermatology of Bamako (HDB), B. P. 251, Bamako, Mali and University of Sciences, Techniques and Technologies De Bamako, B. P. 251, Bamako, Mali, Dicko Adama A. , Sow Ilias ,   CHU Hospital of Dermatology of Bamako (HDB), B. P. 251, Bamako, Mali, Tall Koreissi ,   CHU Hospital of Dermatology of Bamako (HDB), B. P. 251, Bamako, Mali, Nkesu Yannick M. ,   CHU Hospital of Dermatology of Bamako (HDB), B. P. 251, Bamako, Mali, Guindo Binta ,   CHU Hospital of Dermatology of Bamako (HDB), B. P. 251, Bamako, Mali, Mamadou Gassama ,   CHU Hospital of Dermatology of Bamako (HDB), B. P. 251, Bamako, Mali and University of Sciences, Techniques and Technologies De Bamako, B. P. 251, Bamako, Mali, Karabinta Yamoussa ,   CHU Hospital of Dermatology of Bamako (HDB), B. P. 251, Bamako, Mali and University of Sciences, Techniques and Technologies De Bamako, B. P. 251, Bamako, Mali, Faye Ousmane ,   CHU Hospital of Dermatology of Bamako (HDB), B. P. 251, Bamako, Mali and University of Sciences, Techniques and Technologies De Bamako, B. P. 251, Bamako, Mali
Published: January 2023

This 33-year-old lady was hospitalised for systemic lupus and received corticosteroid therapy; upper limb edoema developed as a result. The interview revealed a theory of trauma related to a fall in the bathroom. During the examination, it was discovered that the patient’s overall health was quite poor and that her left upper limb was edematous, unpleasant to the touch, and covered in an erythematous plaque with blisters and a necrosis area. After 72-hours, ciprofloxacin, gentamycin, and amoxicillin antibiotic treatment had no noticeable effects. A bacteriological examination of the ulcer indicated the presence of Providencia stuartii, which is susceptible to cefotaxime but resistant to ciprofloxacin and amoxicillin. The biological evaluation revealed hyperleukocytosis (12,800 white blood cells/L), thrombocytopenia (103,000/L), and anaemia (9.1 g/dL). Following the administration of cefotaxime together with surgical debridement, apyrexia set in within 24-hours, and full recovery occurred three-weeks later. The search for atypical germs and the performance of an antibiogram must be mandated in front of an acute necrotizing dermohypodermatitis (AND) due to the odd location, the circumstances of the occurrence, and the clinical component.
Funciones agroecológicas de los nichos de agrobiodiversidad en la ruralidad de Bogotá, Colombia
Authors: Ortiz Stefan , Quiroga-Manrique Catalina , Monroy-Hernández Julieth , Pérez Darío
Published: January 2023

La expansión de la agricultura industrial en zonas rurales de Bogotá ha reducido la diversidad de plantas cultivadas por las familias campesinas, y ha transformado sus formas de vida y las relaciones bioculturales. Ello afecta los conocimientos ambientales de carácter local y las prácticas de uso y manejo de la agrobiodiversidad. Aunque se ha documentado en varios estudios la presencia de nichos agrobiodiversos, tales como huertas y jardines campesinos que persisten en medio de paisajes homogeneizados, es necesario ampliar la identificación y el análisis de las funciones culturales y agroecológicas que los caracterizan. En este artículo se detallan los conocimientos locales vinculados a huertas y jardines en términos de sus funciones y aportes a la conservación y recuperación de la agrobiodiversidad. Se realizaron entrevistas semiestructuradas a seis sabedores locales y en veinticinco hogares, además de observaciones etnográficas y recorridos etnobotánicos. Con la información obtenida, se caracterizaron las funciones de los nichos de agrobiodiversidad, según las experiencias cotidianas de sus cuidadores y cuidadoras. Se identificaron ocho funciones agroecológicas, 249 nombres comunes asociados al mismo número de especies vegetales, y varios saberes sobre usos y manejos. Se concluye explicando las posibles articulaciones entre los nichos y los paisajes circundantes, para entender su aporte potencial a la transformación territorial y a la conectividad de la estructura ecológica rural de Bogotá.
University 3.0: A Portfolio Approach to Technology R&D Management
Authors:   Russian Presidential Academy of National Economy and Public Administration, Katalevsky Dmitry ,   Skolkovo Institute of Science and Technology, Kosmodemianskaya Natalia ,   Skolkovo Institute of Science and Technology, Arutynyan Arutyun ,   Skolkovo Institute of Science and Technology, Fortin Clement ,   Skolkovo Institute of Science and Technology
Published: January 2023

Modern Universities play increasingly important role in contemporary society, advancing frontiers of science and transforming regional economies. As funding models of modern universities change, they adopt some features of a business organization. While their ability to attract funding becomes vitally important for universities, especially from private sources (industry), a balance between fundamental and applied research becomes vital. The current research investigates 5-years of activities of the Skolkovo Institute of Science and Technology (Skoltech) and particularly its research portfolio. It is based on the theory and practice of the Research Domain Portfolio Matrix (RDPM) approach considering a University to be a portfolio of R&D technologies in diverse scientific areas and at various stages of technology maturity. It is of utmost importance for Universities to find a balance between basic and applied research while making decisions on launching new projects/programs or modifying the existing projects/programs. The proposed RDPM approach helps to leverage limited resources, establish priorities, monitor risks, and influence outcomes in the short and long-term horizons.
Maturity Assessment of Critical Technologies
Authors:   Aeronautics Institute of Technology, Rocha Daiane , Veiga Araujo Gisele Lemes ,   Aeronautics Institute of Technology, Lourenço Melo Francisco Cristovão ,   Aeronautics Institute of Technology
Published: January 2023

A maturity assessment of technological projects is becoming an increasingly popular tool for innovation policy. It enables the accurate determining of risks and opportunities related to the creation of high-tech products. Determining the degree of technology readiness, especially at early stages of development, increases the performance of not only government programs, but also of business projects. This article presents a software interface for such expertise, the IAE/ITA TRL Calculator, designed for the Brazilian aerospace sector. The validation within a number of cases revealed its potential applicability in a wide variety of industries. This innovative software product includes a quality user guide and an improved visual interface that allows for easy and quick identification of issues that require additional effort in order to move the evaluated technology project to a higher level of readiness.
Influence of high temperatures on Post-COVID-19 conditions
Authors: D Hristova , I Simova , T Vekov
Published: January 2023

Patients with chronic diseases are especially vulnerable on hot days because high temperatures lead to exacerbation of a number of cardiovascular, neurological, autoimmune, and other chronic diseases. Acute SARS-CoV-2 infection has left tens of thousands of Bulgarians suffering from a new chronic disease: Post COVID-19 syndrome. The Bulgarian Cardiac Institute, in trend with innovations, has launched the first worldwide study to establish the relationship between high ambient temperatures and Post COVID-19 conditions. It covers 1310 citizens and was held during the hottest month in history - July 2021. Eight districts in Bulgaria are covered, and for each of them, we calculated a number of meteorological parameters and determined their influence on the persistent signs and symptoms. Shumen District is the district with the highest percentage of citizens with peristaltic complaints (86%) and the most pronounced in terms of severity. This is the area with the lowest average daily maximum temperature (28.44º), the highest average night minimum temperature (20.42º), and the lowest average temperature amplitude (8.02º) for July 2021. It is characteristic that the neurological symptoms (dizziness, headache, impaired concentration, and memory) are predominant at a lower temperature amplitude (Shumen district). Symptoms of the cardiovascular system (shortness of breath, fatigue, palpitations, chest pain) are more commonly reported at higher temperature amplitudes (Pleven district). The results of the study show that high values ​​of ambient temperatures affect Post COVID-19 conditions. The most unfavorable effect is exerted by the high average night minimum temperatures and the small temperature amplitude. Cardiovascular symptoms are particularly pronounced at large temperature amplitudes and neurological at small temperature amplitudes. Post-COVID-19 conditions are unpredictable and patient care continues during the hot months.
P0 PLANIFICACIÓN ANUAL v1
Authors: not provided cgarcia
Published: January 2023

Cada curso académico, la EIDUCAM funcionará con un calendario establecido, que se desarrollará en el mes de Mayo del curso anterior. Fechas a fijar para cada curso académico
P4. PROCEDIMIENTO DE ADMISIÓN Y MATRICULACIÓN v1
Authors: not provided cgarcia
Published: January 2023

P4. PROCEDIMIENTO DE ADMISIÓN Y MATRICULACIÓN
P21.- REVISIÓN Y CONTROL DEL PROCESO DE PRESENTACIÓN PLANES DE INVESTIGACIÓN v1
Authors: not provided cgarcia
Published: January 2023

Atendiendo a las particularidades de la Aplicación LAUREA ACADEMIC, el proceso de presentación del Plan de Investigación inicial por parte de los doctorandos, actualmente queda únicamente bajo la supervisión de tutores y directores. Desde la Escuela de Doctorado, creemos que este trámite es fundamental para el desarrollo del Programa y por este motivo facilitaremos a las Comisiones Académicas los mecanismos de control que aseguren que este proceso se realiza correctamente.
Assembly of pAOXHygR vector for protein expression in the yeastPichia pastoris v1
Authors: Kukk Kaia
Published: January 2023

The protocol describes assembly of an Pichia pastoris expression vector composed of the following building blocks: alcohol oxidase 1 (AOX1) promoter, multiple cloning site, myc epitope, 6xHis tag, AOX1 terminator, hygromycin B resistance marker, origin of replication and ampicillin resistance marker. The pAOX1HygR expression vector can be used for integrating the gene of interest into the AOX1 locus of the genome of P. pastoris and the subsequent methanol induced intracellular expression of the recombinant protein. Ampicillin resistance marker is employed for selecting the transformed E. coli cells and hygromycin B resistance marker for selecting the transformed P. pastoris cells. The protocol is part of the article "Identification, characterisation and recombinant expression of flavonoid 3',5'-hydroxylases and cytochrome P450 reductases from Vaccinium species". The protocol was created during implementing the project no 1.1.1.2/VIAA/2/18/286 "Optimization of novel plant derived enzyme expression in microorganisms for biotechnological application" funded by European Regional Development Fund.
Wisecaver Lab CTAB-based extraction of high molecular weight DNA from photosynthetic sea slugs v1
Authors: H Wisecaver Jennifer
Published: January 2023

Protocol for CTAB-based extraction of high molecular weight DNA from photosynthetic sea slugs. This protocol is optimized for samples with highmucopolysaccharide contents and is derived from: Extraction of high molecular weight DNA from molluscs. 1993. Trends in Genetics.Vol 9: pg 407 https://doi.org/10.1016/0168-9525(93)90102-N.
Deglycosylation ofN-glycosylated proteins using PNGase F v1
Authors: Kukk Kaia
Published: January 2023

The described protocol was used to confirm that NADPH-cytochrome P450 reductase from Helianthus annuus was N-glycosylated when recombinantly expressed in Pichia pastoris (Komagataella phaffii).
Pengaruh Kecerdasan Emosional Terhadap Prestasi Belajar Matematika Siswa Kelas V Sekolah Dasar Negeri 1 Manonjaya
Authors: Sulastri Titing , Hidayat Syarip , Suryana Yusuf
Published: January 2023

This study aims to determine the effect of emotional intelligence on mathematics learning achievement of fifth grade students at SD Negeri 1 Manonjaya. The hypothesis tested is: there is an influence of emotional intelligence on mathematics learning achievement of fifth grade students at SDN 1 Manonjaya. The population in the study used all fifth grade students in Manonjaya 1 Elementary School, totaling 41 students consisting of 21 VA class students and 20 VB class students. This type of research is ex post facto. The approach in this study uses a quantitative approach. The independent variable in this study is emotional intelligence while mathematics learning achievement is the dependent variable. Data was collected using emotional intelligence questionnaires and documentation of mathematics learning achievement. Data analysis technique is done by using descriptive analysis and inferential analysis with simple regression analysis techniques. Descriptive analysis results show that the level of emotional intelligence of students in general is included in the moderate category with a percentage of 63.4%. While the description of student mathematics learning outcomes in general are included in the moderate category with a percentage of 61.0%. From the results of inferential analysis using simple linear regression, the equation Y = 70.636 + 0.081X was obtained. From the significant test results obtained a significant value of 0.028 where a significant value 0.05 (0.028 0.05), thus Ha is accepted and Ho is rejected. The conclusion of this study is that there is an influence of emotional intelligence on mathematics learning achievement.
Reshaping Social Capital During the Pandemic Crisis: Age Group Differences in Face‐to‐Face Contact Network Structures
Authors: Dávid Beáta , Herke Boglárka , Huszti Éva , Tóth Gergely , Túry-Angyal Emese , Albert Fruzsina
Published: January 2023

This article presents findings about the impact of the first Covid‐related lockdown on the face‐to‐face (FTF) interpersonal contact networks of the Hungarian adult population. Our primary objective is to understand how the size, composition, and quality of such networks have changed. We base our analysis on the contact‐diary method. Our data were collected from two representative surveys of the Hungarian adult population: one in 2015 (N = 372) and one in May 2020 (N = 1001) during the first wave of the Covid‐19 epidemic. No decline in the overall bonding social capital can be detected; however, social isolation has increased. A restructuring has occurred: a considerable increase manifests in the proportion of kin ties, especially children, and a decrease in the importance of non‐kin ties, with a particularly sharp decline in friendships. FTF contacts indicate an increased emotional intensity (except for non‐kin, non‐household members) and an increase in the length of conversations, but there is a decrease in the frequency of meeting alters. The changes wrought different effects on different age groups, with the restrictions most negatively affecting the size of FTF contact networks for respondents aged 60 years or older. Our findings point to the stability and resilience of close family relations, yet the doubling of social isolation as early as May 2020 underlines fears about the pandemic’s potentially detrimental effects on social connectedness. The decline in friendship ties (and most probably in other weak ties) may lead to a reduction not only in the amount and scope of accessible social capital but also to a weakening social integration.
Underwater Acoustic Sensor Network Data Optimization with Enhanced Void Avoidance and Routing Protocol
Authors: Garg Meenakshi , Sharma Sachin , Balu Mr. Vincent , Sinha Deepak K , Bhatt Dr. Pujita , Bhagat Akash Kumar
Published: January 2023

Deployment of a multi-hop underwater acoustic sensor network (UASN) in a larger region presents innovative challenges in reliable data communications and survivability of network because of the limited underwater interaction range or bandwidth and the limited energy of underwater sensor nodes. UASNs are becoming very significant in ocean exploration applications, like underwater device maintenance, ocean monitoring, ocean resource management, pollution detection, and so on. To overcome those difficulties and attains the purpose of maximizing data delivery ratio and minimizing energy consumption of underwater SNs, routing becomes necessary. In UASN, as the routing protocol will guarantee effective and reliable data communication from the source node to the destination, routing protocol model was an alluring topic for researchers. There were several routing techniques devised recently. This manuscript presents an underwater acoustic sensor network data optimization with enhanced void avoidance and routing (UASN-DAEVAR) protocol. The presented UASN-DAEVAR technique aims to present an effective data transmission process using proficient routing protocols. In the presented UASN-DAEVAR technique, a red deer algorithm (RDA) is employed in this study. In addition, the UASN-DAEVAR technique computes optimal routes in the UASN. To exhibit the effectual results of the UASN-DAEVAR technique, a wide spread experimental analysis is made. The experimental outcomes represented the enhancements of the UASN-DAEVAR model.
Honeynet Implementation in Cyber Security Attack Prevention with Data Monitoring System Using AI Technique and IoT 4G Networks
Authors: Kour Kushnian , Goswami Subhashish , Sharma Dr. Meenakshi , Sivasankar P Thiruvannamalai , Vekariya Dr. Vipul , Kumari Alka
Published: January 2023

Cyber Physical Systems (CPS) comprises of the ubiquitous object concept those are connected with Internet to provide ability of data transmission and sensing over network. The smart appliances transmits the data through CPS devices with the implementation of Internet of Things (IoT) exhibits improved performance characteristics with significant advantages such as time savings, reduced cost, higher human comfort and efficient electricity utilization. In the minimal complexity sensor nodes cyber physical system is adopted for the heterogeneous environment for the wireless network connection between clients or hosts. However, the conventional security scheme uses the mechanisms for desktop devices with efficient utilization of resources in the minimal storage space environment, minimal power processing and limited energy backup. This paper proposed a Secure Honeynet key authentication (SHKA) model for security attack prevention through effective data monitoring with IoT 4G communication. The proposed SHKA model uses the lightweight key agreement scheme for authentication to provide security threats and confidentiality issues in CPS applications. With the implementation of SHKA HoneyNet model the data in IoT are monitored for security mechanism in IoT environment. The middleware module in SHKA scheme uses the Raspberry platform to establish internetworking between CPS device to achieve dynamic and scalability. The secure IoT infrastructure comprises of flexible evaluation of user-centric environment evaluation for the effectiveness. The developed SHKA model perform mutual authentication between CPS devices for minimal computation overhead and efficiency. The wireless channel uses the dynamic session key for the secure communication for cyber-attacks security with lightweight security in CPS system. The SHKA model demonstrate the effectiveness based on consideration of three constraints such as low power processing, reduced storage and minimal backup energy. Experimental analysis stated that proposed SHKA scheme provides lightweight end-to-end key establishment in every session. The CPS devices generates the session key of 128 bit long. The minimum key size is implemented to provide effective security in IoT 4G communication with minimal execution time. The simulation results demonstrated that SHKA model exhibits effective cyber-attacks for the constraint devices to improve performance of IoT network.
Linguistic Based Emotion Detection from Live Social Media Data Classification Using Metaheuristic Deep Learning Techniques
Authors: Mubeen Suraya , Kulkarni Dr Nandini , Tanpoco Manuel R. , Kumar Dr. R.Dinesh , M Lakshmu Naidu , Dhope Tanuja
Published: January 2023

A crucial area of research that can reveal numerous useful insights is emotional recognition. Several visible ways, including speech, gestures, written material, and facial expressions, can be used to portray emotion. Natural language processing (NLP) and DL concepts are utilised in the content-based categorization problem that is at the core of emotion recognition in text documents.This research propose novel technique in linguistic based emotion detection by social media using metaheuristic deep learning architectures. Here the input has been collected as live social media data and processed for noise removal, smoothening and dimensionality reduction. Processed data has been extracted and classified using metaheuristic swarm regressive adversarial kernel component analysis. Experimental analysis has been carried out in terms of precision, accuracy, recall, F-1 score, RMSE and MAP for various social media dataset.
UNISWAP - A CASE STUDY OF DECENTRALIZED EXCHANGES ON THE BLOCKCHAIN
Authors: Koroļkovs Nikolajs , Kodors Sergejs
Published: January 2023

The paper takes a close look at an emerging industry - decentralized finance on the blockchain. The goal of this paper is to compare centralized order book (CLOB)-based exchanges to automated market maker (AMM)-based decentralized exchanges (DEX) and analyze the challenges that AMM-based DEXes are facing today using Uniswap as an example.
Evaluation of the effectiveness of microscopy of surgical material performed by cito in patients with suspected echinococcosis
Authors: Gavrilyuk Timofey V. , Кozlov Sergey S. , Zakharkiv Yuriy F. , Mokrousov Vladimir N. , Saulevich Andrey V. , Abdulazizov Ibrahim G. , Turitsin Vladimir S.
Published: January 2023

BACKGROUND: At present, the relevance of echinococcosis is attributed to its wide prevalence in Russia. More than 30 cases were registered in the countrys 88 administrative territories. In establishing the final diagnosis of echinococcosis, instrumental (ultrasound, computed tomography, and magnetic resonance imaging) and serological methods (determination of specific antibodies based on enzyme-linked immunoassay) are important. However, imaging methods in some cases do not allow to differentiate echinococcal cysts from other volumetric formations, and serological tests can give false-negative results. Hydatidosis is characterized by a long course and is often diagnosed late, when complications develop. The surgical method is considered a radical method of treatment. The diagnosis was confirmed by the results of the pathomorphological examination of the surgical material.
AIM: To examine the effectiveness of parasitological diagnosis of echinococcosis performed by cito using microscopy of cyst contents obtained during surgical intervention.
MATERIALS AND METHODS: The surgical samples were studied in cito using microscopy of cyst contents.
RESULTS: Of the 47 samples examined according to cito, protoscolexes of Echinococcus granulosus were found in 31 (65.7%) patients. In 2 (4.3%) cases, only single hooks of the larvae were found in the samples under study. In 3 (6.4%) patients, the echinococcal nature of the cysts was confirmed by delayed pathomorphological studies of the surgical material with the preparation of histological sections. In 11 (23.4%) patients, the parasitic nature of mass lesions was excluded.
CONCLUSION: Microscopy of the surgical material by cito to detect morphological signs of the parasitic nature of the cyst is a highly effective method that allows confirming the diagnosis of echinococcosis promptly.
Comparative evaluation of the results of anthropometric indicators and measurements of body composition by bioimpedancemetry
Authors: Dzen Natalya V. , Gabbasova Natalia V. , Esaulenko Igor E. , Mamchik Nikolay P. , Popov Valery I.
Published: January 2023

Background. Various anthropometric and instrumental methods are used to assess the correspondence between height and body weight of a person.
Aim. Carrying out a comparative assessment of the results of anthropometric indicators and bioimpedance analysis among men and women fitness center visitors.
Material and methods. A cross-sectional study of 58 men and 62 women was carried out. Participants underwent standard anthropometry (measurement of height with a stadiometer; body weight with an electronic scale; measurement of waist circumference and hip circumference with a centimeter tape) and bioimpedancemetry. Statistical processing was carried out by non-parametric methods: to study the relationship between the phenomena, the Spearman rank correlation coefficient was used, the differences in the average indicators were calculated by the Student's t-test, relative indicators by the Pearson 2 test, the differences were considered statistically significant at p 0.05.
Results. Correlation analysis of the main calculated anthropometric and bioimpedance parameters established a strong relationship between body mass index and adipose tissue content (r=0.87). According to the data of bioimpedance analysis in the group of men, there was a significant predominance of muscle mass over fat, both in normal and overweight (p 0.0001). In the course of a comparative assessment of body mass index and bioimpedance analysis indicators, it was found that the use of body mass index is more often associated with overdiagnosis of overweight (p=0.0067). In the group of women, bioimpedancemetry analysis showed the predominance of muscle tissue over adipose tissue only with a normal body mass index, with overweight, the predominance of adipose tissue was found (p 0.0001). According to the results of bioimpedancemetry, the frequency of the norm decreased by 1.5 times compared with the body mass index (p=0.0017), the proportion of obesity increased by 4 times (p=0.0017) and the proportion of overweight almost 1.4 times.
Conclusion. A comprehensive assessment of the body composition by bioimpedancemetry in men established the predominance of muscle mass over fat, which made it possible to reduce the frequency of overdiagnosis of excess body weight by 2 times; in women, body mass index was associated with underdiagnosis of overweight.
Kazan Trachomatous Institute in historical retrospective: background and circumstances of its opening
Authors: Khusainova Dina C. , Ivanov Anton Yu. , Ivanova Regina G.
Published: January 2023

The article is devoted to the study of the prerequisites and circumstances of the first trachomatous institute establishment in Russia, designed to stop the spread of a dangerous infectious eye disease in one of the key regions of the RSFSR the Republic of Tatarstan. The initial period of the spread of trachoma in the Russian Empire, dating back to the first quarter of the 19th century, is characterized, and the first steps in the study and treatment of trachoma in the Kazan province are defined. On the basis of archival documents, many of which were not previously introduced into scientific circulation, the authors analyze a significant layer of historical information that sheds light on a number of facts that have not been previously published or studied. The prerequisites that characterize the formation of the attitude of the Kazan scientific community to the need to organize the fight against a new spreading disease trachoma on a large scale, have been identified. For the first time, prosopographic data on the first leaders of the institute were clarified, it was convincingly proved that, contrary to popular belief, it was not V.V.Chirkovsky, but A.G.Agababov who became the first director of the Trachomatous Institute in Kazan. Materials on the circumstances and conditions of the actual opening of the trachomatous institute in 1922 are given. The features of the fight against trachoma in the period preceding the opening of the trachomatous institute, starting with the activities of E.V.Adamyuk, representatives of the Kazan Governorate and special medical commissions, ending with the formation of a specialized scientific and clinical infrastructure, are identified.
Satisfacción del personal de salud y pacientes sobre un servicio de telesalud de un hospital de Perú
Authors: Barriga-Chambi Fernanda , Ccami-Bernal Fabricio , Alarcón-Casazuela Alberto Luciano , Copa-Uscamayta Julissa , Yauri-Mamani Jeremy , Oporto-Arenas Brenda , Quispe-Juli Cender Udai
Published: January 2023

Objetivos. Evaluar el nivel de satisfacción con el servicio de telesalud del Hospital III Regional Honorio Delgado (HRHD) por parte del personal de salud y los pacientes atendidos, así como el nivel de madurez de implementación de dicho servicio. Materiales y métodos. Estudio observacional transversal llevado a cabo desde octubre a diciembre del 2021. La satisfacción del personal de salud y de los pacientes fueron evaluadas con la encuesta de Glaser et al. y el cuestionario Telemedicine Satisfaction Questionnaire (TSQ), respectivamente. El nivel de madurez del servicio se evaluó mediante la herramienta de medición del nivel de madurez de las instituciones de salud para implementar servicios de telemedicina de la Organización Panamericana de la Salud. Resultados. Se obtuvieron 129 respuestas del personal desalud. El número de profesionales no médicos satisfechos con el servicio de telesalud fue mayor al de médicos (72,5% vs 18,3%). De los 377 pacientes, el 77,6% manifestó estar satisfecho con el servicio. Con respecto al nivel de madurez, el servicio de telemedicina del HRHD cuenta con 32% de ítems en estado nulo, 40,8% en iniciado, 25,2% en avanzado y 2% en listo. Conclusiones. La satisfacción de los médicos fue menor a la de los otros profesionales de la salud. Los pacientes reportaron una satisfacción moderadamente alta. La implementación del servicio de telesalud en el HRHD se orienta hacia un nivel nulo o iniciado. Es importante que los tomadores de decisiones consideren la satisfacción de usuarios durante la implementación y seguimiento de los servicios de telesalud.
REVIEW ON KNOWLEDGE GAP IN Brachiaria GRASS RESEARCH AND UTILIZATION: ETHIOPIAN PERSPECTIVE
Authors: ARDELEAN Ana Valentina , MOROSANU Ana Maria , ARDELEAN Ioan , MOISESCU Cristina , CORNEA Calina Petruta
Published: January 2023

The ability of cyanobacteria and green microalgae to synthesize gold nanoparticles is well known, as is the ability to use these nanoparticles to degrade pollutants (e.g., methyl orange, methylene blue, etc.). In this paper we present our original results on the biosynthesis of gold nanoparticles in both light and dark, by the cyanobacterium Synechocystis PCC 6803, green microalga Chlorella sorokiniana UTEX 1230, as well as our two green microalgae strains temporarily named Ra and Rd. In this way we try to find out the contribution of photosynthesis to the synthesis of nanoparticles, as well as the contribution of aerobic respiration to this process. Up to our best knowledge this is the first report concerning the possibility to influence the intracellular position of nanoparticles by varying the conditions of NP synthesis, namely in our experiments the darkness coupled with anaerobiosis. The synthesized nanoparticles were inspected by TEM, both in situ (on ultra-thin sections) and after extraction. The collected gold nanoparticles were further used as catalysts for the degradation of methylene blue.
MITIGATION OF DROUGHT STRESS IN Solanaceae VEGETABLES THROUGH SYMBIOSIS WITH PLANT GROWTH - PROMOTING BACTERIA AND ARBUSCULAR MYCORRHIZAL FUNGI. A REVIEW
Authors: JIMENEZ-PEREZ Marisa , MORALES-MANZO Ivan Ilich , FITA Ana , RODRIGUEZ-BURRUEZO Adrian
Published: January 2023

Plants constitute dynamic systems with different strategies to face biotic and abiotic stress. Water deficit is one of the most challenging abiotic factors increased by climate change, affecting seriously the quality of soils and crop yields, decreasing photosynthetic rate, increasing the accumulation of free radicals, and modifying root morphology. In this regard, the potential role of the host plant - arbuscular mycorrhizal fungi (AMF) and plant growth-promoting bacteria (PGPB) interactions within the rhizosphere in the alleviation of drought stress is being deeply studied. These symbiotic relationships not only allow a major nutrient and water uptake, but also could be integrated as a sustainable approach to improve the growth and productivity of crops under water scarcity conditions. A better comprehension of the mechanisms of these synergies between PGPB and AMF with plants is becoming an important key to develop effective applications of these natural symbiosis. In this work, the highlighted knowledge concerning these associations and their effect in the response of plants under drought stress have been reviewed, focusing on the interactions described in Solanaceae vegetables, one of the most relevant crops in the Mediterranean area.
WHEAT BIOLOGICAL YIELD VARIATION IN RELATION TO NITROGEN AND FOLIAR BIOSTIMULATOR TREATMENT
Authors: MACRA Gabriela , SALA Florin
Published: January 2023

The study evaluated the variation of biological yield in wheat, the Alex variety, under the influence of nitrogen and foliar biostimulator. Nitrogen was applied to the ground, in five variants (N0, N50, N100, N150, N200), in doses between 0 to 200 kg ha<sup<-1</sup<. The Superfifty biostimulator (Sf) was applied foliar, six variants (Sf0, Sf1, Sf2, Sf3, Sf4, Sf5) on each level of N fertilization, in concentrations between 0 - 5 L ha<sup<-1</sup<. Biological yield was determined in the BBCH code 9 stage. The variation of the biological yield of wheat, Alex cultivar, under the influence of fertilization with Superfifty product, in the six concentrations tested, on the five levels of N, was described by polynomial equations of order 2 and 3, in statistical safety conditions. The regression analysis evidenced the variation of biological yield, as the direct influence and interaction of the two factors (N and Sf), in general conditions of statistical safety, according to R<sup<2</sup< = 0.984, p <0.001. The ANOVA test confirmed the statistical certainty of the values of the coefficients of the obtained equation (p = 0.00749 for a; p<0.001 for b; p<0.001 for c; p<0.001 for d; p<0.001 for e).
THE USE OF CO-CULTIVATION OF AROMATIC, MEDICINAL PLANTS AND VEGETABLES IN SUSTAINABLE URBAN HORTICULTURE
Authors: MAKNEA Kristina Ilectra , ASANICA Adrian , FABIAN Claudia , PETICILA Adrian , TZORTZI Julia Nerantzia , POPESCU Dan
Published: January 2023

Reliable access to safe, economic and nutritious food was at increasing risk many decades ago, burdening society andsocial relations, especially in urban areas. It is now known that climate change, the pandemics and the economic crisisare directly responsible for food security. For this reason, science has undertaken to safeguard the future of food. Anyproposal to reduce the catastrophic effects of the climate crisis on cities must be based on ecological farming methods toachieve sustainable urban horticulture. Co-cultivation is an old forgotten cultivation method, beneficial to mankind andthe environment. It can make a positive contribution to the agri-food planning of a city and to tackling the effects ofclimate change. A bibliographic review is carried out in the Mediterranean region concerning the co-cultivation(companion planting) of aromatic-medicinal plants and vegetables on the University premises (USAMV Bucharest). Anattempt is made to evaluate the adaptability of Mediterranean plants and the evolution of their co-cultivation. The resultsof this research will be useful to city managers, architects, agronomists, etc. This work aims to prove through acomparative method that the use of co-cultivation is a critical factor in sustainable urban agriculture and, consequently,food security and that climate change can affect people's eating habits
PARTICLE DISTRIBUTION IN GRANULAR SYNBIOTIC PRODUCTS
Authors: DONEVA Maria , NACHEVA Iliana , METODIEVA Petya
Published: January 2023

This article presents an analysis of the particle distribution of granular lyophilized synbiotic products. The main purpose of the present study is to find a relationship between the particle size distribution and the varying component in the composition of the products. Particle size measurements were performed with an ANALYSETTE 22 NanoTec plus analyzer. The results obtained we then subjected to statistical analysis to study the distribution properties of functional food samples. It has been found that for the preparation of granules with a low degree of dusting it is optimal to use 10% sucrose, 1% locus bean gum and 1% fructooligosaccharides (FOS) for processing the lyophilized mixture. Determining the distribution of granules is directly dependent on their composition and purpose. The natural composition of the granulated ''LIO - Milk strawberry'' and ''LIO - Milk chokeberry'' guarantees exceptional uniformity in use, as well as prevention of possible oxidation.
EVOLUTION AT THE MICROFERMENTER LEVEL OF THE GROWTH DYNAMICS OF Saccharomyces cerevisiae AND Starmella bacillaris YEASTS WITH POTENTIAL FOR USE IN WINEMAKING AT THE PIETROASA WINERY
Authors: BARBULESCU Iuliana Diana , DUMITRACHE Corina , DIGUTA Camelia Filofteia , BEGEA Mihaela , MATEI Petruta Mihaela , FRINCU Mihai , MARCULESCU Simona Ioana , CIRIC Alexandru Ionut , TUDOR Valerica , BOROIU Elena Mirela , TEODORESCU Razvan Ionut
Published: January 2023

The grape surface hosts a complex community of yeast Saccharomyces and non-Saccharomyces species responsible for spontaneous alcoholic fermentation in wine industry. The yeast strains used for this study were isolated from ‘Tămâioasă Românească’ and ‘Busuioacă de Bohotin’ grape varieties from Pietroasa vineyard, and the isolates were identified through a molecular method. Identification of yeast strains through the BLASTn analysis of the 5.8S-ITS region revealed that PFE5 strain showed the best sequence match to Saccharomyces cerevisiae (98% similarity) and PFE15 strain to Starmerella bacillaris (99.78% similarity), respectively. In this first micro-pilot study, the differences between Sacharomyces and non-Saccharomyces yeasts in batch (for Starmella bacillaris) and fed-batch fermentation system (for S. cerevisae) and how these regimes influence the culture growth were assessed. The applied fed-batch process was capable for producing two times more S. cerevisae yeast biomass than Starmella bacillaris through a batch process. In addition, the yield of S. cerevisiae converting the substrate into biomass was 42.3%, almost double compared to the yield of Starmella bacillaris. Moreover, the cell wet weight (WCW) for S. cerevisae was 32.5 g/L and for Starmella bacillaris 15.35 g/L, respectively. Both yeast biomass will be used at Pietroasa winery for inoculation separately or mixed as co-culture for ‘Tămâioasă Românească’ and ‘Busuioacă de Bohotin’ grape juice.
MЕTHOD FOR OBTAINING A CAKE FROM MIXED FLOURS FROM RYE, OATS AND TRITICALE
Authors: LAZOVA-BORISOVA Iliana
Published: January 2023

The aim of the study was to establish a method for obtaining a cake from mixes of rye, oats and triticale. The physicochemical, fatty acid and mineral composition of oat flour, rye and triticale was studied. A series of attempts were made for trial laboratory baking of cake from the mixes. A technological scheme of the technological process has been established. The quality indicators of the finished product have been studied. Organoleptic evaluation and qualitative characteristics of the cake were performed. The cake contains functional ingredients such as soluble and insoluble fiber, β-glucans, macroelements, microelements, fatty acids composition. The cake is rich in oleic and linoleic acid. The finished product is rich in K, Fe and Zn.
ECOLOGICAL ELASTICITY OF SOYBEAN VARIETIES’ PERFORMANCE ACCORDING TO CLIMATIC FACTORS IN UKRAINE
Authors: MELNYK Andriy , ROMANKO Yuriy , DUDKA Anhelina , CHERVONA Vika , BRUNYOV Maxim , SOROKOLIT Evhen
Published: January 2023

This research aimed to determine the ecological elasticity of soybean varieties’ performance of different maturity groups in the Sumy, Ternopil, and Mykolaiv regions. In the course of the research, 10 fast-growing, 6 early-ripening, 4 middle-early, and 3 mid-ripening varieties of domestic and foreign selection were used. The results of the analysis of the obtained data show that the formation of varieties’ yield capacity is directly dependent on the length of the growing season, the amount of precipitation, and the temperatures. It was found that the highest level of yield capacity (2.75 t/ha on average) is formed by early-maturing soybean varieties, among which the Merlin variety is characterized by the highest yield - 3.08 t/ha.
STUDY OF VARIABILITY OF WINTER WHEAT VARIETIES AND LINES IN TERMS OF WINTER HARDNESS AND DROUGHT RESISTANCE
Authors: NAZARENKO Mykola , IZHBOLDIN OLeksandr , IZHBOLDINA Olena
Published: January 2023

The research objective was to identify the peculiarities of the emergence of resistance to adverse environmental factors (winter period and droughts), the assessment of local and foreign mutant lines and varieties for resistance by means of proven express tests. It has been confirmed that both traits are slightly variable under the effect of gamma irradiation. The lines and varieties with such traits have been identified, the relationship between the grain productivity in winter wheat has been described, the availability of these traits has been established, as well as the need to take them into account at creating an up-to-date variety model for the conditions of insufficient humidification with a harsh continental climate (North Steppe of Ukraine) in the conditions of climate change. It has been shown that drought resistance remains the key trait, but the possible mechanism for the realization of the genetically determined yield potential by a variety can also be the timing of ripeness, which may help avoiding the most critical periods (middle and early ripeness).
A REVIEW OF POSTBIOTICS AS NEW HEALTH PROMOTERS
Authors: PRISTAVU Mircea Cosmin , DIGUTA Camelia , COULIBALY Wahauwouele Hermann , YOUTEFANCHE Sandrine A.. , DOPCEA Getuta , MATEI Florentina
Published: January 2023

For a long time, probiotics have been widely used as safe microorganisms that can confers a health benefit effects on the host, directly or indirectly. Recently, postbiotics have gained interest as new health promoters. Postbiotics have recently been defined as complex mixture of functional bioactive compounds secreted by probiotics during a fermentation process (such as biosurfactants, proteins, short chain fatty acids, organic acids, bacteriocins, vitamins etc.). According to current data, postbiotics have advantages over live probiotics with regard to: ease extraction, standardization, and storage, availability for industrial-scale-up, specific mechanism of action, impossible to transfer and acquire antibiotic resistance genes and their interaction with the cellular receptors to trigger the targeted responses. However, several aspects related to postbiotics have not been fully elucidated. Here, we provided a critical review of the postbiotic definition, mechanisms of action, underlying their beneficial effects, as well as current trends for applications in foods and pharmaceuticals.