bluuebunny/crossref_metadata_2025 huggingface dataset:
“Getting the Left Right”
Authors: Klinke Marianne E. , Zahavi Dan , Hjaltason Haukur , Thorsteinsson Björn , Jónsdóttir Helga
Published: January 2015

We used a phenomenological approach to gain insight into the experiences of self, other, and world in patients with hemispatial neglect within the first month following stroke. Comprehensive descriptions of circumstances were conjoined with open-ended interviews of 12 participants. The neglect experience was captured in the overarching theme, “getting the left right,” which encompasses the two subthemes of (a) surreal awareness of the left and (b) emergence of a different world. Patients had unclear perceptions of their own body and surroundings, their attention was brittle, and they encountered bewildering reactions from other people. They simultaneously pursued the ineffable neglected space and searched for coherence. The vulnerability, loss, and conflicting perceptions that patients with neglect face should be acknowledged and alleviation sought. Facilitating methods should provide additional opportunities for patients to communicate their experiences. We underscore the importance of readjusting the current approaches of neglect and emphasizing meaningfulness in professional guidance.
Career Adapt-Abilities Scale–Short Form (CAAS-SF)
Authors: Maggiori Christian , Rossier Jérôme , Savickas Mark L.
Published: January 2015

The Career Adapt-Abilities Scale (CAAS) has become one of the most widely used questionnaires to assess career adaptability. To facilitate its integration into large surveys, in varied settings, the aim of this article was to develop a brief 12-item version, the Career Adapt-Abilities Scale–Short Form (CAAS-SF). A sample of 2,800 French- and German-speaking adults living in Switzerland completed the CAAS. On a first random subsample, a principal component analyses conducted on the CAAS-SF suggested a four-factor solution. A one-to-one association was found between these components and the subscales of the CAAS-SF. Confirmatory factor analyses, conducted on a second random subsample, confirmed the hierarchical factor structure of this short version. Based on Cheung and Rensvold’s criteria, the CAAS-SF reached measurement equivalence across linguistic and gender groups. Furthermore, the 12- and 24-item versions were strongly associated. The results supported the CAAS-SF as pertinent and economical alternative to the 24-item version.
Oligodendroglial Development
Authors: Huang Nanxin , Niu Jianqin , Feng Yue , Xiao Lan
Published: January 2015

In the central nervous system, the generation of mature oligodendrocytes from their progenitors is a critical step in myelination, which is essential for normal nervous system function. Thus, understanding the regulatory mechanism underlying oligodendroglial development is of great importance, especially for the development of new therapeutic strategies that promote remyelination in demyelinating diseases, such as multiple sclerosis. Previous studies have focused on genetic patterns and revealed a network of cell signaling pathways and related transcription factors involved in oligodendroglial lineage development. Recently, epigenetic regulation, which refers to regulation of gene expression by adjusting the environment of the genes has been shown to play a profound role during oligodendroglial development. In this review, we summarize the recent data demonstrating the effects of chromatin modification and remodeling in regulating oligodendroglial development and discuss the use of high-throughput analysis and bio-informatics in future studies.
Effects of Coaching on the Implementation of Functional Assessment–Based Parent Intervention in Reducing Challenging Behaviors
Authors: Fettig Angel , Schultz Tia R. , Sreckovic Melissa A.
Published: January 2015

This study examined the effects of coaching on the implementation of functional assessment–based parent intervention in reducing children’s challenging behaviors. A multiple baseline across participants design was used with three parent–child dyads with children between the ages of 2 and 5 years. The intervention consisted of training and delayed coaching to examine the effects of coaching following the training session. Results document that when coaching was provided, parents were able to implement the function-based strategies consistently at a high level, which resulted in the reduction of children’s challenging behaviors. Contributions to the literature, implications, and future directions are discussed.
Differential pathways of positive and negative health behavior change in congestive heart failure patients
Authors: Chaves Covadonga , Park Crystal L
Published: January 2015

This longitudinal study applied a stress and coping model to examine the differential pathways of perceived positive and negative health behavior changes. Participants with congestive heart failure completed self-report measures of psychological resources, coping strategies, and perceived behavior changes and were assessed again 6 months later. Patients with higher positive affect and spiritual well-being reported more positive health behavior changes over time, effects mediated by approach coping. Alternatively, patients with lower psychological resources reported more negative behavior changes over time, effects mediated by avoidance coping. The results suggest that different psychological resources are related to different types of coping which, in turn, are associated with perceived positive or negative changes in health behavior over time.
When general practitioners talk about Alcohol: Exploring facilitating and hampering factors for pragmatic case finding
Authors: lid Torgeir Gilje , Nesvåg Sverre , Meland Eivind
Published: January 2015

Background: The aim was to explore individual and system factors facilitating or hampering pragmatic case finding, an identification strategy based on clinical signs and targeted screening. Study design: Two focus groups with general practitioners were interviewed twice, in the context of a four-session seminar on alcohol and complex drug problems, and an additional focus group interview with general practitioners not attending the seminar. Interviews focused mainly on conditions for talking about alcohol, views on collaboration with colleagues, how they deal with complex issues, and strategies for learning and quality improvement. Results: The participants presented many deliberate strategies for quality improvement and learning together, but there was a tendency to avoid discussing complex case stories or potentially controversial topics with colleagues. Possible barriers to change were presented. The majority of their stories on talking about alcohol coincided well with the concept of pragmatic case finding. The duality between shame and normality, time constraints and a need for structure were the most important individual barriers to an open and respectful conversation about alcohol with patients. Conclusions: Our study supports pragmatic case finding as a relevant and viable strategy for talking about alcohol in general practice, and as an alternative to screening and brief intervention. Quality improvement in practice is strengthened when it is adapted to the clinical setting, and builds on and stimulates the GPs’ and staff’s own strategies for learning and quality work.
Cancer incidence among waiters: 45 years of follow-up in five Nordic countries
Authors: Reijula Jere , Kjaerheim Kristina , Lynge Elsebeth , Martinsen Jan I. , Reijula Kari , Sparén Pär , Tryggvadottir Laufey , Weiderpass Elisabete , Pukkala Eero
Published: January 2015

Aims: To study cancer risk patterns among waiters in the Nordic countries. Methods: We identified a cohort of 16,134 male and 81,838 female waiters from Denmark, Finland, Iceland, Norway and Sweden. During the follow-up period from 1961 to 2005, we found that 19,388 incident cancer cases were diagnosed. Standardised incidence ratio (SIR) was defined as the observed number of cancer cases divided by the expected number, based on national age, time period and gender-specific cancer incidence rates in the general population. Results: The SIR of all cancers in waiters, in the five countries combined, was 1.46 (95% CI 1.41–1.51) in men and 1.09 (1.07–1.11) in women. In male waiters, the SIR decreased from 1.79 (1.63–1.96) in 1961–1975, to 1.33 (1.26–1.40) in 1991–2005, but remained stable among women. The SIR among male waiters was highest for cancers in the pharynx (6.11; 95% CI 5.02–7.37), oral cavity (4.91; 95% CI 3.81–6.24) and tongue (4.36; 95% CI 3.13–5.92); and in female waiters, in the larynx (2.17; 95% CI 1.63–2.82), oral cavity (1.96; 95% CI 1.60–2.34) and lung (1.89; 95% CI 1.80–1.99). Conclusions: The risk of cancer among waiters was higher than in the general population. The elevated incidence in some cancer sites can likely be explained by higher alcohol consumption, the prevalence of smoking and occupational exposure to tobacco smoke. Hopefully, the incidence of cancer among waiters will decrease in the future, due to the banning of tobacco smoking in restaurants and bars in the Nordic countries.
The value of telehealth in the early detection of chronic obstructive pulmonary disease exacerbations: A prospective observational study
Authors: Hamad Ghassan A , Crooks Michael , Morice Alyn H
Published: January 2015

We aim to establish the value of telemonitoring in the early detection of chronic obstructive pulmonary disease exacerbations. We followed up patients undergoing chronic obstructive pulmonary disease telemonitoring for 4 months. We studied changes in the telemonitored data in the week prior to admission or to community chronic obstructive pulmonary disease exacerbation. A total of 183 patients were studied. In all, 30 chronic obstructive pulmonary disease-related hospital admissions and 68 chronic obstructive pulmonary disease community exacerbations were recorded. Changes in telehealth parameters occurred in 80 per cent (24/30) of admissions and 82 per cent (56/68) of community exacerbations. Although changes in telehealth data occurred in the majority of exacerbations, most individual symptoms was present in less than half the exacerbations and almost 20 per cent of exacerbations were not preceded by any change in telemonitoring data. Cough created significantly more alerts by those treated in the community (p = 0.008), whereas a drop in oxygen saturation created significantly more alerts pre-hospitalisation (p = 0.049). We conclude that further work is required to develop methods of identifying impending chronic obstructive pulmonary disease exacerbations with greater sensitivity and specificity.
Jacquard UNIVAL 100 parameters study for high-density weaving optimization
Authors: Mathieu Decrette , Sabri Mourad , Jean-François Osselin , Jean-Yves Drean
Published: January 2015

3D structures for composites, and especially 3D woven preforms use, is growing because of high-performance fibres improvements, field diversification and applications complexity. Critical industries like the air-space industry need a perfect control of processes and products’ final properties. Among other 3D weaving techniques, multilayer weaving is interesting for the diversity and complexity of possible 3D structures. A new Jacquard shedding technology called UNIVAL 100 which can be used with multilayer weaving, has appeared few years ago and uses actuators instead of the traditional Jacquard hooks. It is synonym of great improvements, as such a technology should enable controlling perfectly the way yarns are moving during shedding. The aim of this paper is first to describe their operating mode. It is our basis for a design of experiments development, the purpose of which is to experimentally determine the effects of UNIVAL parameters on process quality, in the case of high-density multilayer woven fabrics (which we will further call HDMW fabrics).
Partisan Competition and the Efficiency of Lawmaking in American State Legislatures, 1991-2009
Authors: Hicks William D.
Published: January 2015

Does partisan competition explain why some legislatures are more efficient at processing legislation than others? This article argues that legislative parties’ strategic incentives and capabilities are a function of their size, their ideological homogeneity, and the governor’s party. It shows that the distribution of legislative seats between the parties influences legislative efficiency, depending on the level of polarization between the parties and the party of the governor. A small partisan seat margin reduces legislative efficiency when the parties are polarized and when the government is divided. It provides further evidence that polarization and divided government can either positively or negatively affect legislative efficiency, depending on the distribution of seats held between the two parties. This research contributes to the literature by demonstrating the conditional influence of political parties. Based in multilevel modeling techniques, this research also contributes to the literature with robust evidence including 48 state legislatures, through 19 years.
Exploring Organizational Alignment-Employee Engagement Linkages and Impact on Individual Performance
Authors: Alagaraja Meera , Shuck Brad
Published: January 2015

We explore existing perspectives of organizational alignment and employee engagement from the literature to better understand the alignment-engagement linkages to individual performance. This is an underexplored area of inquiry in human resource development (HRD). Our analysis of the alignment and engagement literatures resulted in the development of an exploratory conceptual model. The conceptual model elaborates on the organizational alignment–employee engagement linkages and their impact on individual performance. These interconnections emphasize the importance of developing internally consistent HRD interventions or programs that align individual skills and knowledge with job characteristics and organizational systems and routines. Furthermore, the model highlights the dynamic nature of the alignment-engagement linkages both as a source and context which facilitates individual performance, and influences the extent to which employees exhibit essential as well as discretionary behaviors. We elaborate on the implications for HRD theory, research, and practice.
The MICHR Genomic DNA BioLibrary
Authors: Roessler Blake J. , Steneck Nicholas H. , Connally Lisa
Published: January 2015

In this article, we report on an effort to study the development and usefulness of a large, broad-use, opt-in biorepository for genomic research, focusing on three ethical issues: providing appropriate understanding, recruiting in ways that do not comprise autonomous decisions, and assessing costs versus benefits. We conclude the following: (a) Understanding can be improved by separating the task of informing subjects from documenting informed consent (Common Rule) and permission to use personal health information and samples for research (Health Insurance Portability and Accountability Act [HIPAA]); however, regulations might have to be changed to accommodate this approach. (b) Changing recruiting methods increases efficiency but can interfere with subject autonomy. (c) Finally, we propose a framework for the objective evaluation of the utility of biorepositories and suggest that more attention needs to be paid to use and sustainability.
Digital Solutions for Informed Decision Making
Authors: Owens Otis L. , Friedman Daniela B. , Brandt Heather M. , Bernhardt Jay M. , Hébert James R.
Published: January 2015

African American (AA) men are significantly more likely to die of prostate cancer (PrCA) than other racial groups, and there is a critical need to identify strategies for providing information about PrCA screening and the importance of informed decision making (IDM). To assess whether a computer-based IDM intervention for PrCA screening would be appropriate for AA men, this formative evaluation study examined their (1) PrCA risk and screening knowledge; (2) decision-making processes for PrCA screening; (3) usage of, attitudes toward, and access to interactive communication technologies (ICTs); and (4) perceptions regarding a future, novel, computer-based PrCA education intervention. A purposive convenience sample of 39 AA men aged 37 to 66 years in the Southeastern United States was recruited through faith-based organizations to participate in one of six 90-minute focus groups and complete a 45-item descriptive survey. Participants were generally knowledgeable about PrCA. However, few engaged in IDM with their doctor and few were informed about the associated risks and uncertainties of PrCA screening. Most participants used ICTs on a daily basis for various purposes including health information seeking. Most participants were open to a novel, computer-based intervention if the system was easy to use and its animated avatars were culturally appropriate. Because study participants had low exposure to IDM for PrCA, but frequently used ICTs, IDM interventions using ICTs (e.g., computers) hold promise for AA men and should be explored for feasibility and effectiveness. These interventions should aim to increase PrCA screening knowledge and stress the importance of participating in IDM with doctors.
Consultation for Small-Sized Penis in the Egyptian Males
Authors: Salama Nader
Published: January 2015

This study aimed to report penile dimensions in adult Egyptian males consulting for small-sized penis (SSP) and describe their demographics and andrological profile. A case control study was designed through retrospective data analysis of patients ( n = 239) seeking advice for SSP and a control group ( n = 59). This included sociodemographics, other andrological complaints, and penile dimensions (pendulous length [PL], penopubic or total length [TL], and circumference [CF]) at flaccid and erect states and the size of the prepubic fatty pad. The results reported that most patients were single, students, and smokers and had not completed a university education. Several patients reported falsely premature ejaculation (PE), penile curvature (PC), and small-sized testes. Most penile dimensions of the patients (mean, cm) were significantly lower than those of the controls, whether in flaccid (PL: 7.4 vs. 8.05, p = .008; CF: 8.7 vs. 8.98, p = .026) or erect state (PL: 11.8 vs. 13, p = .000; TL: 14.2 vs. 15, p = .000; CF: 11.3 vs. 11.8, p = .003). However, no patient presented with a pendulous penile length <4 cm in flaccid or <7 cm in erect state. In conclusion, Egyptian men consulting for SSP did not have true small organs, but their penile dimensions were slightly smaller than those of men without such complaint. The proper sexual education program is highly advisable in these situations to avoid the myths and misconceptions about sexuality.
Expression and bioregulation of the kallikrein-related peptidases family in the human neutrophil
Authors: Lizama Alejandro J , Andrade Yessica , Colivoro Patricio , Sarmiento Jose , Matus Carola E , Gonzalez Carlos B , Bhoola Kanti D , Ehrenfeld Pamela , Figueroa Carlos D
Published: January 2015

The family of kallikrein-related peptidases (KLKs) has been identified in a variety of immunolabeled human tissue sections, but no previous study has experimentally confirmed their presence in the human neutrophil. We have investigated the expression and bioregulation of particular KLKs in the human neutrophil and, in addition, examined whether stimulation by a kinin B1 receptor (B1R) agonist or fMet-Leu-Phe (fMLP) induces their secretion. Western blot analysis of neutrophil homogenates indicated that the MM of the KLKs ranged from 27 to 50 kDa. RT-PCR showed that blood neutrophils expressed only KLK1, KLK4, KLK10, KLK13, KLK14 and KLK15 mRNAs, whereas the non-differentiated HL-60 cells expressed most of them, with exception of KLK3 and KLK7. Nevertheless, mRNAs for KLK2, KLK5, KLK6 and KLK9 that were previously undetectable appeared after challenging with a mixture of cytokines. Both kinin B1R agonist and fMLP induced secretion of KLK1, KLK6, KLK10, KLK13 and KLK14 into the culture medium in similar amounts, whereas the B1R agonist caused the release of lower amounts of KLK2, KLK4 and KLK5. When secreted, the differing proteolytic activity of KLKs provides the human neutrophil with a multifunctional enzymatic capacity supporting a new dimension for its role in human disorders of diverse etiology.
Current Emotion Research in Cultural Neuroscience
Authors: Chiao Joan Y.
Published: January 2015

Classical theories of emotion have long debated the extent to which human emotion is a universal or culturally constructed experience. Recent advances in emotion research in cultural neuroscience highlight several aspects of emotional generation and experience that are both phylogenetically conserved as well as constructed within human cultural contexts. This review highlights theories and methods from cultural neuroscience that examine how cultural and biological processes shape emotional generation, experience, and regulation across multiple time scales. Recent advances in the neurobiological basis of culture-bound syndromes, such as Hwa-Byung (fire illness), provide further novel insights into emotion and mental health across cultures. Implications for emotion research in cultural neuroscience for population health disparities in psychopathology and global mental health will be discussed.
Alemtuzumab in the treatment of multiple sclerosis: key clinical trial results and considerations for use
Authors: Havrdova Eva , Horakova Dana , Kovarova Ivana
Published: January 2015

Alemtuzumab is a humanized monoclonal antibody therapy that has recently been approved in over 30 countries for patients with active relapsing-remitting multiple sclerosis. It acts by targeting CD52, an antigen primarily expressed on T and B lymphocytes, resulting in their depletion and subsequent repopulation. The alemtuzumab clinical development program used an active comparator, subcutaneous interferon beta-1a, to show that alemtuzumab is a highly efficacious disease-modifying therapy, with benefits on relapses, disability outcomes, and freedom from clinical disease and magnetic resonance imaging activity. The safety profile was consistent across studies and no new safety signals have emerged during follow-up in the extension study. Infusion-associated reactions are common with alemtuzumab, but rarely serious. Infection incidence was elevated with alemtuzumab in clinical studies; most infections were mild or moderate in severity. Autoimmune adverse events occurred in approximately a third of patients, manifesting mainly as thyroid disorders, and less frequently as immune thrombocytopenia or nephropathy. A comprehensive monitoring program lasting at least 4 years after the last alemtuzumab dose allows early detection and effective management of autoimmune adverse events. Further experience with alemtuzumab in the clinic will provide needed long-term data.
Dimethyl fumarate in the treatment of relapsing–remitting multiple sclerosis: an overview
Authors: Bomprezzi Roberto
Published: January 2015

Multiple sclerosis (MS) shares an immune-mediated origin with psoriasis. Long-term safety and efficacy data generated in Europe from usage of fumaric acid formulations in the latter disease constituted grounds to investigate their effects in MS patients. Dimethyl fumarate (DMF) was found to be the active principle in those formulations and in vitro studies have demonstrated that DMF has immune-modulatory properties exerted through abilities to divert cytokine production toward a Th2 profile, both on lymphocytes and microglial cells. More importantly, DMF was discovered to impact the anti-oxidative stress cell machinery promoting the transcription of genes downstream to the activation of the nuclear factor (erythroid derived 2)-like2 (NRF2). DMF exposure increases the cytosol concentrations of NRF2, which besides immune regulatory effects, has the potential for cytoprotection on glial cells, oligodendrocytes and neurons. Extensive and rigorous clinical trials have assessed the efficacy and safety of DMF at the dose of 240 mg twice and three times a day in relapsing-remitting MS patients during one phase IIb and two phase III trials. Robust, positive results were obtained across a number of clinical and paraclinical parameters. In one study (DEFINE), the relative reductions of the adjusted annualized relapse rate of the low and high dose regimens in comparison with placebo were 53% and 48%, respectively ( p < 0.001 for both comparisons). In the other trial (CONFIRM), DMF decreased the annualized relapse rate in comparison with placebo by 44% in the lower and by 51% in higher dosage group (also p < 0.001). The number and size of lesions as detected by magnetic resonance imaging were also significantly decreased in comparison with the patients receiving DMF at every dosage. Multiple post hoc and subgroup analyses corroborated the clinical data, rendering DMF an appealing medication whose potential for impacting the degenerative aspects of MS remains to be explored.
Knowledge, attitude and practice of standard precautions of infection control by hospital workers in two tertiary hospitals in Nigeria
Authors: Ogoina Dimie , Pondei Kemebradikumo , Adetunji Babatunde , Chima George , Isichei Christian , Gidado Sanusi
Published: January 2015

Background:

Standard precautions are recommended to prevent transmission of infection in hospitals. However, their implementation is dependent on the knowledge and attitudes of healthcare workers (HCW). This study describes the knowledge, attitude and practice (KAP) of standard precautions of infection control among HCW of two tertiary hospitals in Nigeria is described.

Methods:

A cross-sectional study was undertaken in 2011/2012 among HCW in two tertiary hospitals in Nigeria. Data was collected via a structured self-administered questionnaire assessing core elements of KAP of standard precautions. Percentage KAP scores were calculated and professional differences in median percentage KAP scores were ascertained.

Results:

A total of 290 HCW participated in the study (76% response rate), including 111 (38.3%) doctors, 147 (50.7%) nurses and 32 (11%) laboratory scientists. Overall median knowledge and attitude scores toward standard precautions were above 90%, but median practice score was 50.8%. The majority of the HCW had poor knowledge of injection safety and complained of inadequate resources to practise standard precautions. House officers, laboratory scientists and junior cadres of nurses had lower knowledge and compliance with standard precautions than more experienced doctors and nurses.

Conclusion:

Our results suggest generally poor compliance with standard precautions of infection control among HCW in Nigeria. Policies that foster training of HCW in standard precautions and guarantee regular provision of infection control and prevention resources in health facilities are required in Nigeria.
Outbreak Column 16: Cognitive errors in outbreak decision making
Authors: Curran Evonne T
Published: January 2015

During outbreaks, decisions must be made without all the required information. People, including infection prevention and control teams (IPCTs), who have to make decisions during uncertainty use heuristics to fill the missing data gaps. Heuristics are mental model short cuts that by-and-large enable us to make good decisions quickly. However, these heuristics contain biases and effects that at times lead to cognitive (thinking) errors. These cognitive errors are not made to deliberately misrepresent any given situation; we are subject to heuristic biases when we are trying to perform optimally. The science of decision making is large; there are over 100 different biases recognised and described. Outbreak Column 16 discusses and relates these heuristics and biases to decision making during outbreak prevention, preparedness and management. Insights as to how we might recognise and avoid them are offered.
Emotional wellbeing and mental health: an exploration into health promotion in young people and families
Authors: Coverdale Gillian E , Long Andrew F
Published: January 2015

Aims:

Promoting mental health and emotional wellbeing (EWB) in children and young people (YP) is vitally important for their psycho-social development. Critical review of the literature reveals a dearth of research that has explored the perspective of the child, adolescent or adult in this concept, with much research being intervention focused and promoted at crisis level. The current study aims to address this gap in understanding of young persons’ and parents’ perspectives.

Method:

A small-scale, exploratory qualitative study was conducted with YP, and parents of YP aimed at exploring the meaning of EWB and how it could be promoted. Data were collected via focus groups with 15 YP (aged 18–24 years) and 15 interviews with parents of a different group of YP.

Results:

Study participants identified key constructs for good EWB as stability, coping ability, happiness, confidence, balance, empathy and being grounded. Feeling comfortable with self, managing and controlling emotions and having the confidence to persevere with challenges were all felt to contribute to a positive sense of EWB. Sources of support were overwhelmingly cited as family and friends, with schools identified as a potentially good environment for supporting and promoting the EWB of pupils. Participants stressed the need for a positive attitude change towards YP, advocating this as promoting a sense of belonging and community citizenship. A lay-informed ‘recipe’ for successful EWB promotion is drawn out, centred on the core goal of raising awareness and understanding of YP’s EWB, in the YP themselves, their parents, schools and the wider community.

Conclusions:

This research provides key messages for society, policy makers, education and public health and healthcare practitioners for integration into the delivery of services for YP and families that include education on supporting EWB, activities for YP and a multi-agency approach to supporting families within the community.
A Review of the Benefits of Satureja Species on Metabolic Syndrome and Their Possible Mechanisms of Action
Authors: Babajafari Siavash , Nikaein Farzad , Mazloomi Seyed Mohammad , Zibaeenejad Mohammad Javad , Zargaran Arman
Published: January 2015

Metabolic syndrome, also known as insulin resistance disorder, is the simultaneous manifestation of multiple metabolic disorders in an individual. The present-day complementary and alternative therapies suggest several medicinal herbs that may have the potential to improve one or multiple complications of metabolic syndrome. All of them have their own limitations in efficacy and unwanted effects. Therefore, we reviewed species of Satureja as widespread medicinal herbs and potentially good remedies for metabolic syndrome. We reviewed literature found in PubMed and the ISI Web of Knowledge with the key word Satureja in the title. The influence of any species of Satureja on any disease or syndrome, enzymatic, metabolic, or physiological pathways, in human, animals, or in vitro conditions related to any characteristics of metabolic syndrome were considered. The main outcomes of treatment with Satureja species were categorized, and the possible mechanisms of action are discussed in this article.
Manifestations and clinical impact of pediatric inherited thrombophilia
Authors: Klaassen Irene L. M. , van Ommen C. Heleen , Middeldorp Saskia
Published: January 2015

The etiology of pediatric venous thromboembolic disease (VTE) is multifactorial, and in most children, 1 or more clinical risk factors are present. In addition, inherited thrombophilic disorders contribute to the development of pediatric VTE. In this review, the role of inherited thrombophilic disorders in the development of pediatric VTE, as well as the benefits and limitations of thrombophilia testing, will be discussed.
The role of the ADAMTS13 cysteine-rich domain in VWF binding and proteolysis
Authors: de Groot Rens , Lane David A. , Crawley James T. B.
Published: January 2015

Key Points

A comprehensive analysis of the ADAMTS13 Cys-rich domain identifies a novel functional interaction between ADAMTS13 and VWF.
How I treat advanced classical Hodgkin lymphoma
Authors: Johnson Peter , McKenzie Hayley
Published: January 2015

The development of curative systemic treatment of Hodgkin lymphoma was recently voted one of the top 5 achievements of oncology in the last 50 years (http://cancerprogress.net/top-5-advances-modern-oncology). The high expectation of cure (above 80%) with initial therapy, even for advanced disease, is tempered by the recognition of some important limitations: not all patients are cured, especially those in older age groups, and patients have suffered debilitating or, in some cases, fatal long-term side effects. The challenge for modern treatment approaches is to improve the cure rate and, at the same time, minimize the long-term damage resulting from treatment. After several decades during which we have tested a variety of different ways to combine conventional cytotoxic treatments with or without radiotherapy but have identified no effective new approaches, the field is once again moving forward. The developments that hold the greatest promise in this respect are the application of functional imaging with 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) to make an early judgment of the success of treatment and the introduction of some highly active new agents such as antibody-drug conjugates.
Characterization of an autosomal dominant bleeding disorder caused by a thrombomodulin mutation
Authors: Dargaud Yesim , Scoazec Jean Yves , Wielders Simone J. H. , Trzeciak Christine , Hackeng Tilman M. , Négrier Claude , Hemker H. Coenraad , Lindhout Theo , Castoldi Elisabetta
Published: January 2015

Key Points

The THBD c.1611C>A mutation (p.Cys537Stop) causes extremely high soluble thrombomodulin levels resulting in trauma-related bleeding. Soluble thrombomodulin acts by enhancing activated protein C generation and by impairing factor Va, factor VIIIa, and thrombin generation.
Qualitative and quantitative reservoir bitumen characterization: A core to log correlation methodology
Authors: Saidian Milad , Rasmussen Torben , Nasser Mosab , Mantilla Andres , Tobin Rick
Published: January 2015

Reservoir bitumen is a highly viscous, asphaltene-rich hydrocarbon that can have important effects on reservoir performance. Discriminating between producible oil and reservoir bitumen is critical for recoverable hydrocarbon volume calculations and production planning, yet the lack of resistivity contrast between the two makes it difficult, if not impossible, to make such differentiation using conventional logs. However, the nuclear magnetic resonance (NMR) response in bitumen-rich zones is dominated by short transverse relaxation times ([Formula: see text]) and a low apparent fluid hydrogen index ([Formula: see text]), providing an opportunity to identify the presence of reservoir bitumen. Therefore, NMR logging technology becomes crucial in the characterization of reservoirs in which the presence of bitumen may be of concern. We used NMR and other log data to identify and quantify the occurrence of reservoir bitumen in a carbonate reservoir. A thorough petrophysical evaluation was performed using a full suite of logs, formation pressure measurements, and laboratory core analysis data. We discuss several quick methods to identify intervals with a higher chance of reservoir bitumen presence. The short transverse relaxation times ([Formula: see text]) and consequently lower [Formula: see text] logarithmic mean time values are characteristics of bitumen-rich zones. Another characteristic is low [Formula: see text] in these zones and consequently lower NMR porosity estimates when compared to porosity estimates from the density and neutron tools. We analyzed 2D longitudinal-transverse relaxation time ([Formula: see text]) maps for core samples at different depths to confirm the presence of reservoir bitumen in some wells using laboratory low-field NMR data. We observed a high [Formula: see text] ratio at various depths, which is an indication of high-molecular-weight hydrocarbons. The presence of bitumen at the same depths was confirmed by thin section analysis, and it is the likely cause for failed formation pressure testing attempts at those depth intervals. Partial cleaning of reservoir bitumen-rich core plugs results in helium-injection porosity estimates that are too low, and they are closer to the NMR porosity than to density porosity, the latter being more consistent with actual values. In addition, the grain density (GD) calculated by He injection is significantly lower than the GD estimated from elemental capture spectroscopy and X-ray diffraction techniques. Disregarding these effects complicates the core to log correlation, which is common practice for porosity calculations using the density log. A volumetric rock model was used to reconcile core and log data as well as to calculate the saturation of reservoir bitumen. The methodologies for reservoir bitumen characterization introduced here can be applied successfully in different reservoirs for more reliable and precise reservoir evaluation and production planning.
William Spanos’s Exile Legacies: A Ritornello
Authors: Pease Donald E.
Published: January 2015

This article discusses the importance of Auseinandersetzung to William Spanos’s untimely exile legacies.
Tetraspanin CD9 and ectonucleotidase CD73 identify an osteochondroprogenitor population with elevated osteogenic properties
Authors: Singh Anju , Lester Chantel , Drapp Rebecca , Hu Dorothy Z. , Glimcher Laurie H. , Jones Dallas
Published: January 2015

Cell-based bone regeneration strategies offer promise for traumatic bone injuries, congenital defects, non-union fractures and other skeletal pathologies. Postnatal bone remodeling and fracture healing provide evidence that an osteochondroprogenitor cell is present in adult life that can differentiate to remodel or repair the fractured bone. However, cell-based skeletal repair in the clinic is still in its infancy, mostly due to poor characterization of progenitor cells and lack of knowledge about their in vivo behavior. Here, we took a combined approach of high-throughput screening, flow-based cell sorting and in vivo transplantation to isolate markers that identify osteochondroprogenitor cells. We show that the presence of tetraspanin CD9 enriches for osteochondroprogenitors within CD105+ mesenchymal cells and that these cells readily form bone upon transplantation. In addition, we have used Thy1.2 and the ectonucleotidase CD73 to identify subsets within the CD9+ population that lead to endochondral or intramembranous-like bone formation. Utilization of this unique cell surface phenotype to enrich for osteochondroprogenitor cells will allow for further characterization of the molecular mechanisms that regulate their osteogenic properties.
Investigation of Organoiron Catalysis in Kumada–Tamao–Corriu-Type Cross-Coupling Reaction Assisted by Solution-Phase X-ray Absorption Spectroscopy
Authors: Takaya Hikaru , Nakajima Sho , Nakagawa Naohisa , Isozaki Katsuhiro , Iwamoto Takahiro , Imayoshi Ryuji , Gower Nicholas J , Adak Laksmikanta , Hatakeyama Takuji , Honma Tetsuo , Takagaki Masafumi , Sunada Yusuke , Nagashima Hideo , Hashizume Daisuke , Takahashi Osamu , Nakamura Masaharu
Published: January 2015

Solution-phase synchrotron X-ray absorption spectroscopy (XAS) is a powerful tool for structural and mechanistic investigations of paramagnetic organoiron intermediates in solution-phase reactions. For paramagnetic organotransition metal intermediates, difficulties are often encountered with conventional NMR- and EPR-based analyses. By using solution-phase XAS, we succeeded in identifying the organoiron species formed in the reaction of iron bisphosphine with mesitylmagnesium bromide, MesMgBr, and 1-bromodecane in a [FeX2(SciOPP)]-catalyzed Kumada–Tamao–Corriu (KTC)-type cross-coupling reaction. X-ray absorption near-edge structure (XANES) spectra showed that the resulting aryliron species possessed a divalent oxidation state. Extended X-ray absorption fine structure (EXAFS) demonstrated that the solution-phase molecular geometries of these species are in satisfactory agreement with the crystallographic geometries of [FeIIBrMes(SciOPP)] and [FeIIMes2(SciOPP)]. By combining GC-quantitative analysis and solution-phase XAS, the cross-coupling reactivities of these aryliron species were successfully investigated in the reaction with 1-bromodecane under stoichiometric and catalytic conditions.
Optical and Flame-retardant Behavior of Polycarbonate Composites Containing Perfluorodecyltriethoxysilane-modified Silicate Microspheres
Authors: Tang Anjie , Ding Peng , Zhao Yu , Song Na , Shi Liyi
Published: January 2015

A facile method was carried out to obtain polycarbonate (PC) light-diffusion material with good optical and flame-retardant properties. The key procedure was the surface modification of silicate microspheres (SMSs) by 1H,1H,2H,2H-perfluorodecyltriethoxysilane (FTDS). By this way, only use one kind of filler could realize multifunction at small amount loadings and the obtained PC composites showed good antidripping performance.
Pyridazine-3,6-diol-annulated Tetrathiafulvalene: Self-assembly and Fiber Formation Triggered by Diamine Addition
Authors: Inoue Ryota , Hasegawa Masashi , Mazaki Yasuhiro
Published: January 2015

Self-assembly and fibrous structure formation based on pyridazine-3,6-diol-annulated tetrathiafulvalene derivative were investigated. Although the molecules formed a trimeric assembly with complementary hydrogen bonds in solution, the addition of water produced micrometer fibrous structures. On the other hand, mixing of diamines (NH2–R–NH2) promoted reorganization of the self-assembly, and various nanoobjects were formed.
The Impacts of Microfinance: Evidence from Joint-Liability Lending in Mongolia
Authors: Attanasio Orazio , Augsburg Britta , De Haas Ralph , Fitzsimons Emla , Harmgart Heike
Published: January 2015

We present evidence from a randomized field experiment in rural Mongolia to assess the poverty impacts of a joint-liability microcredit program targeted at women. We find a positive impact of access to group loans on female entrepreneurship and household food consumption but not on total working hours or income in the household. A simultaneously introduced individual-liability microcredit program delivers no significant poverty impacts. Additional results on informal transfers to families and friends suggest that joint liability may deter borrowers from using loans for noninvestment purposes with stronger impacts as a result. We find no difference in repayment rates between both types of microcredit. (JEL G21, I32, I38, J16, L26, O15, O16)
Six Randomized Evaluations of Microcredit: Introduction and Further Steps
Authors: Banerjee Abhijit , Karlan Dean , Zinman Jonathan
Published: January 2015

Causal evidence on microcredit impacts informs theory, practice, and debates about its effectiveness as a development tool. The six randomized evaluations in this volume use a variety of sampling, data collection, experimental design, and econometric strategies to identify causal effects of expanded access to microcredit on borrowers and/or communities. These methods are deployed across an impressive range of locations—six countries on four continents, urban and rural areas—borrower characteristics, loan characteristics, and lender characteristics. Summarizing and interpreting results across studies, we note a consistent pattern of modestly positive, but not transformative, effects. We also discuss directions for future research. (JEL D14, G21, I38, O15, O16, P34, P36)
Further available immunization option to prevent pneumococcal disease
Authors: Vojtek Ivo , Hoet Bernard
Published: January 2015

In their recent review, Charles Feldman and Ronald Anderson provide an overview of various clinical aspects of pneumococcal infections. We would like to complete this report by providing some additional information on a widely-used immunization option, which was not originally mentioned in the article. The protein D pneumococcal conjugate vaccine (PHiD-CV) has been pre-approved by WHO and its impact is supported by real-life data from the regions of its use.
Congruence and joint space width alterations of the medial compartment following lateral unicompartmental knee arthroplasty
Authors: Zuiderbaan H. A. , Khamaisy S. , Thein R. , Nawabi D. H. , Pearle A. D.
Published: January 2015

Progressive degenerative changes in the medial compartment of the knee following lateral unicompartmental arthroplasty (UKA) remains a leading indication for revision surgery. The purpose of this study is to evaluate changes in the congruence and joint space width (JSW) of the medial compartment following lateral UKA. The congruence of the medial compartment of 53 knees (24 men, 23 women, mean age 13.1 years; sd 62.1) following lateral UKA was evaluated pre-operatively and six weeks post-operatively, and compared with 41 normal knees (26 men, 15 women, mean age 33.7 years; sd 6.4), using an Interactive closest point algorithm which calculated the congruence index (CI) by performing a rigid transformation that best aligns the digitised tibial and femoral surfaces. Inner, middle and outer JSWs were measured by sub-dividing the medial compartment into four quarters on pre- and post-operative, weight bearing tunnel view radiographs. The mean CI of knees following lateral UKA significantly improved from 0.92 (sd 0.06) pre-operatively to 0.96 (sd 0.02) (p < 0.001) six weeks post-operatively. The mean CI of the healthy control group was 0.99 sd 0.01. Post-operatively, the mean inner JSW increased (p = 0.006) and the outer decreased (p = 0.002). The JSW was restored post-operatively as no significant differences were noted in all three locations compared with the control group (inner JSW p = 0.43; middle JSW p = 0.019, outer JSW p = 0.51).

Our data suggest that a well conducted lateral UKA may improve the congruence and normalise the JSW of the medial compartment, potentially preventing progression of degenerative change.

Cite this article: Bone Joint J 2015;97-B:50–5.
Which patient characteristics influence length of hospital stay after primary total hip arthroplasty in a ‘fast-track’ setting?
Authors: den Hartog Y. M. , Mathijssen N. M. C. , Hannink G. , Vehmeijer S. B. W.
Published: January 2015

After implementation of a ‘fast-track’ rehabilitation protocol in our hospital, mean length of hospital stay for primary total hip arthroplasty decreased from 4.6 to 2.9 nights for unselected patients. However, despite this reduction there was still a wide range across the patients’ hospital duration. The purpose of this study was to identify which specific patient characteristics influence length of stay after successful implementation of a ‘fast-track’ rehabilitation protocol. A total of 477 patients (317 female and 160 male, mean age 71.0 years; 39.3 to 92.6, mean BMI 27.0 kg/m2;18.8 to 45.2) who underwent primary total hip arthroplasty between 1 February 2011 and 31 January 2013, were included in this retrospective cohort study. A length of stay greater than the median was considered as an increased duration. Logistic regression analyses were performed to identify potential factors associated with increased durations. Median length of stay was two nights (interquartile range 1), and the mean length of stay 2.9 nights (1 to 75). In all, 266 patients had a length of stay ≤ two nights. Age (odds ratio (OR) 2.46; 95% confidence intervals (CI) 1.72 to 3.51; p <  0.001), living situation (alone vs living together with cohabitants, OR 2.09; 95% CI 1.33 to 3.30; p = 0.002) and approach (anterior approach vs lateral, OR 0.29; 95% CI 0.19 to 0.46; p <  0.001) (posterolateral approach vs lateral, OR 0.24; 95% CI 0.10 to 0.55; p < 0.001) were factors that were significantly associated with increased length of stay in the multivariable logistic regression model.

Cite this article: Bone Joint J 2015;97-B:19–23.