bluuebunny/crossref_metadata_2025 huggingface dataset:
The temporality and accessibility of message types (TAMT) model: Examining social media message types and the associations between exposure to alcohol and binge drinking
Authors: Vranken Sofie , Kurten Sebastian , Beullens Kathleen
Published: November 2022

Scholars have indicated that social media contribute to various health-related behaviors (e.g., substance use, body dissatisfaction) among adolescents. This study adds to the literature on health-related social media effects through theoretical advances supported by empirical evidence. First, we introduce the TAMT model, in which we assess the media environment along a continuum of two dimensions: the temporality (from ephemeral to persistent) and accessibility (from private to public) of message types. By combining these dimensions, we argue that there are four message types: ephemeral private, persistent private, ephemeral public, and persistent public. Second, we draw on the TAMT model to advance our knowledge of the role of social media in alcohol-related behaviors. We expected that, due to the distinctive characteristics of the four message types, they would be differently related to alcohol references and binge drinking. Based on cross-sectional data (N = 1,636, Mage = 15, SD = 1.17), we found that moderate alcohol references are encountered across all message types, while more extreme references are more likely to be prevalent in ephemeral public and ephemeral private messages. We show that exposure to moderate and extreme alcohol use references in ephemeral private and persistent private messages was associated with a higher probability of engaging in binge drinking, whereas exposure to ephemeral public and persistent public messages was not. Ephemeral private messages played the most crucial role in the association with binge drinking. These findings illustrate the importance of broadening the scope of research to ephemeral private environments when studying health-related behaviors. While we have illustrated the usefulness of the TAMT model against the background of two specific types of alcohol references, this new model can be extended to other behaviors (e.g., sexual risk-taking behaviors, cyberbullying).
An exploratory study of selfie motivations and their relation to sociability and shyness among youth
Authors: Morciano Daniele , Musso Pasquale , Cassibba Rosalinda , Devlin Maurice
Published: November 2022

The study explored how motivations for taking and sharing selfies vary among youth, with reference to the personality traits based on the combination of shyness and sociability. In contrast with a predominantly pathological vision of the selfie, this study considered a wider range of motivations reported by young people when asked why they click and share selfies. Further to motivations that may be symptomatic of problems (e.g., exhibitionism, attention seeking), the study considered the selfie also as a possible positive experience (e.g., identity development, biographical memory-preserving). Based on a survey administered to a sample of 2,323 undergraduate students, the study evidenced that selfies tend to be a self-referential experience for shy and unsociable individuals (the Solitary Shy profile), as they showed a higher incidence of exhibitionism, attention-seeking and low self-esteem. A multifaceted selfie practice prevails among Shy-Sociable participants (the Uncomfortably Sociable profile), as they seem to exploit different functions of a selfie to cope with their own shyness and, at the same time, to follow their inclination towards face-to-face interactions. Unshy-Sociable participants (the Comfortably Sociable profile) stand out for a tendency to share selfies to nurture social relationships. The need to keep in touch with a limited social circle prevails among Unshy-Unsociable individuals (the Socially Selective profile).
Possibility Tout Court
Authors: Adler Yuval ,   The Heidegger Circle
Published: November 2022

A leitmotif of Being and Time is the attempt to reverse the classical priority of actuality over possibility: instead of understanding the possible in terms of the actual – as “arising out of the actual and returning to it” – Heidegger insists on grasping possibility as the primordial notion. Nowhere is it more evident than in his complex treatment of death and dying. Death is exactly that possibility which offers nothing actual in terms of which to grasp it; death only is in our ever being-toward it. I focus on Heidegger’s characterization of being-toward-death as rooted in, and a concretion of, Dasein’s being-toward-itself. This approach yields an interpretation of the notorious “possibility of impossibility” formulation that is diametrically opposed to the so-called “world-collapse” interpretations. I then explore why, and in what sense, Dasein’s being-toward-itself needs a concretion and draw conclusions about the organization of Being and Time as whole.
Two and One-Half Arguments for Idealism
Authors: Gilbert Bennett ,   Philosophy Documentation Center
Published: November 2022

John Foster, an Oxford analytical philosopher, and Borden Parker Bowne, the founder of “Boston Personalism” at the turn of the twentieth century both presented unique arguments for idealism that are deeply different from one another. Because neither is now well known, this paper lays out their reasoning as carefully and as clearly as possible, finding Bowne’s case for personalist idealism to be the stronger of the two in terms of ontology. But the inquiry is framed on the problems of the moral affordances of ontology and of the need of moral philosophy for grounding in ontology. Although this is a very large area, a partial conclusion—the “half argument” of the title—is drawn for further development.
Underestimation of endoscopic size in large gastric epithelial neoplasms
Authors: Song Jae Sun , Kim Byung Sun , Yang Min A , Lee Young Jae , Jung Gum Mo , Kim Ji Woong , Cho Jin Woong
Published: November 2022

Background/Aims: Endoscopic submucosal dissection (ESD) is an effective method for resecting gastric adenomas and adenocarcinomas. A significant discrepancy was observed between endoscopic and pathological sizes in samples obtained from patients undergoing ESD. This study elucidates the factors affecting size discrepancy after formalin fixation.Methods: The records of 64 patients with 69 lesions were analyzed, including 50 adenomas and 19 adenocarcinomas. Data on location, gross shape, histology, and size after fixation in formalin were collected.Results: The mean size of the resected specimen appeared to decrease after formalin fixation (37.5 mm prefixation vs. 35.8 mm postfixation, p<0.05). The mean long axis diameter of the lesions was 20.3±7.9 mm prefixation and 13.4±7.9 mm postfixation. Size differences in lesions smaller than 20 mm were significantly greater than those in lesions larger than 20 mm (7.6±5.6 mm vs. 2.5±5.8 mm, p<0.01). In multivariate analysis, a tumor size of ≥20 mm was found to be an independent factor affecting size postformalin fixation (p<0.05).Conclusions: The endoscopic size of lesions before ESD may be underestimated in tumors larger than 20 mm in size. Therefore, increased attention must be paid during ESD to avoid instances of incomplete resection.
Comparison between a novel core knife and the conventional IT knife 2 for endoscopic submucosal dissection of gastric mucosal lesions
Authors: Park Myeongsoon , Lee Jin Wook , Shin Dong Woo , Kim Jungseok , Lee Yoo Jin , Lee Ju Yup , Cho Kwang Bum
Published: November 2022

Background/Aims: Few studies have compared the performances of endoscopic knives. This study aimed to compare the therapeutic outcomes of a novel core knife and the conventional IT knife 2 for endoscopic submucosal dissection (ESD) of gastric mucosal lesions.Methods: This prospective, non-inferiority trial included patients diagnosed with gastric adenoma or early-stage adenocarcinoma at Keimyung University Dongsan Hospital between June and November 2020. The patients were randomly assigned to either the core knife or the IT knife 2 group. The operators and assistants scored the knives’ grip convenience and cutting abilities.Results: A total of 39 patients were enrolled (core knife group, 20 patients; IT knife 2 group, 19 patients). There were no significant between-group differences in operator-assessed grip convenience (9.600 vs. 9.526, p=0.753), cutting ability (9.600 vs. 9.105, p=0.158), or assistant-assessed grip convenience (9.500 vs. 9.368, p=0.574).Conclusions: The core knife achieved therapeutic outcomes that were comparable to those of the IT knife 2 for ESD of gastric mucosal lesions.
Nigeria’s Sub – Regional Diplomacy: Nigeria’s role in promoting West African Institutions
Authors: Nikez Adu Yao , Nwalie George Avele
Published: November 2022

The study examines Nigerian subregional diplomacy: study of Nigeria’s role in promoting West African Institutions The study focuses on Nigeria’s relations with West African institutions such as the Lake Chad Basin Commission, the Gulf of Guinea Commission and the Economic Community of West African States (ECOWAS). The authors consider in detail Nigeria’s national interests vis-à-vis West African institutions and Member States. To achieve the objective of the study, the authors pay particular attention to Nigeria’s bilateral relations with neighbouring States and cooperation with African institutions. The study is based on the theory of political realism, which implies constant competition among States defending their national interests. In the process of studying this problem, the authors apply institutional, analytical and problem-chronological methods. The main conclusions of the study are the establishment of Nigeria’s role in the settlement of border and territorial disputes, which enabled the state to interact and cooperate with its neighbours, the importance of Nigeria’s contribution to the peacekeeping of the region, Identifying the stability of Nigeria’s foreign policy towards both Africa as a whole and neighbouring States, analysing the main problems of the West African region, which is the basis of Nigeria’s subregional diplomacy: insecurity, political instability and economic imbalance. Moreover, the authors provide critical analysis of Nigeria’s institutional cooperation. The relevance of the study is due to the growing political and economic influence of Nigeria on the African continent.
High spatial resolution analysis using automated indentation mapping differentiates biomechanical properties of normal vs. degenerated articular cartilage in mice
Authors: Masson Anand O , Besler Bryce , Edwards W Brent , Krawetz Roman J
Published: November 2022

Characterizing the biomechanical properties of articular cartilage is crucial to understanding processes of tissue homeostasis vs. degeneration. In mouse models, however, limitations are imposed by their small joint size and thin cartilage surfaces. Here we present a three-dimensional (3D) automated surface mapping system and methodology that allows for mechanical characterization of mouse cartilage with high spatial resolution. We performed repeated indentation mappings, followed by cartilage thickness measurement via needle probing, at 31 predefined positions distributed over the medial and lateral femoral condyles of healthy mice. High-resolution 3D x-ray microscopy (XRM) imaging was used to validate tissue thickness measurements. The automated indentation mapping was reproducible, and needle probing yielded cartilage thicknesses comparable to XRM imaging. When comparing healthy vs. degenerated cartilage, topographical variations in biomechanics were identified, with altered thickness and stiffness (instantaneous modulus) across condyles and within anteroposterior sub-regions. This quantitative technique comprehensively characterized cartilage function in mice femoral condyle cartilage. Hence, it has the potential to improve our understanding of tissue structure-function interplay in mouse models of repair and disease.
Improving the accuracy of single-trial fMRI response estimates using GLMsingle
Authors: Prince Jacob S , Charest Ian , Kurzawski Jan W , Pyles John A , Tarr Michael J , Kay Kendrick N
Published: November 2022

Advances in artificial intelligence have inspired a paradigm shift in human neuroscience, yielding large-scale functional magnetic resonance imaging (fMRI) datasets that provide high-resolution brain responses to thousands of naturalistic visual stimuli. Because such experiments necessarily involve brief stimulus durations and few repetitions of each stimulus, achieving sufficient signal-to-noise ratio can be a major challenge. We address this challenge by introducing GLMsingle, a scalable, user-friendly toolbox available in MATLAB and Python that enables accurate estimation of single-trial fMRI responses (glmsingle.org). Requiring only fMRI time-series data and a design matrix as inputs, GLMsingle integrates three techniques for improving the accuracy of trial-wise general linear model (GLM) beta estimates. First, for each voxel, a custom hemodynamic response function (HRF) is identified from a library of candidate functions. Second, cross-validation is used to derive a set of noise regressors from voxels unrelated to the experiment. Third, to improve the stability of beta estimates for closely spaced trials, betas are regularized on a voxel-wise basis using ridge regression. Applying GLMsingle to the Natural Scenes Dataset and BOLD5000, we find that GLMsingle substantially improves the reliability of beta estimates across visually-responsive cortex in all subjects. Comparable improvements in reliability are also observed in a smaller-scale auditory dataset from the StudyForrest experiment. These improvements translate into tangible benefits for higher-level analyses relevant to systems and cognitive neuroscience. We demonstrate that GLMsingle: (i) helps decorrelate response estimates between trials nearby in time; (ii) enhances representational similarity between subjects within and across datasets; and (iii) boosts one-versus-many decoding of visual stimuli. GLMsingle is a publicly available tool that can significantly improve the quality of past, present, and future neuroimaging datasets sampling brain activity across many experimental conditions.
Tree species and genetic diversity increase productivity via functional diversity and trophic feedbacks
Authors: Tang Ting , Zhang Naili , Bongers Franca J , Staab Michael , Schuldt Andreas , Fornoff Felix , Lin Hong , Cavender-Bares Jeannine , Hipp Andrew L , Li Shan , Liang Yu , Han Baocai , Klein Alexandra-Maria , Bruelheide Helge , Durka Walter , Schmid Bernhard , Ma Keping , Liu Xiaojuan
Published: November 2022

Addressing global biodiversity loss requires an expanded focus on multiple dimensions of biodiversity. While most studies have focused on the consequences of plant interspecific diversity, our mechanistic understanding of how genetic diversity within plant species affects plant productivity remains limited. Here, we use a tree species × genetic diversity experiment to disentangle the effects of species diversity and genetic diversity on tree productivity, and how they are related to tree functional diversity and trophic feedbacks. We found that tree species diversity increased tree productivity via increased tree functional diversity, reduced soil fungal diversity, and marginally reduced herbivory. The effects of tree genetic diversity on productivity via functional diversity and soil fungal diversity were negative in monocultures but positive in the mixture of the four tree species tested. Given the complexity of interactions between species and genetic diversity, tree functional diversity and trophic feedbacks on productivity, we suggest that both tree species and genetic diversity should be considered in afforestation.
Large-scale analysis and computer modeling reveal hidden regularities behind variability of cell division patterns in Arabidopsis thaliana embryogenesis
Authors: Laruelle Elise , Belcram Katia , Trubuil Alain , Palauqui Jean-Christophe , Andrey Philippe
Published: November 2022

Noise plays a major role in cellular processes and in the development of tissues and organs. Several studies have examined the origin, the integration or the accommodation of noise in gene expression, cell growth and elaboration of organ shape. By contrast, much less is known about variability in cell division plane positioning, its origin and links with cell geometry, and its impact on tissue organization. Taking advantage of the first-stereotyped-then-variable division patterns in the embryo of the model plant Arabidopsis thaliana, we combined 3D imaging and quantitative cell shape and cell lineage analysis together with mathematical and computer modeling to perform a large-scale, systematic analysis of variability in division plane orientation. Our results reveal that, paradoxically, variability in cell division patterns of Arabidopsis embryos is accompanied by a progressive reduction of heterogeneity in cell shape topology. The paradox is solved by showing that variability operates within a reduced repertoire of possible division plane orientations that is related to cell geometry. We show that in several domains of the embryo, a recently proposed geometrical division rule recapitulates observed variable patterns, suggesting that variable patterns emerge from deterministic principles operating in a variable geometrical context. Our work highlights the importance of emerging patterns in the plant embryo under iterated division principles, but also reveal domains where deviations between rule predictions and experimental observations point to additional regulatory mechanisms.
Mother cells control daughter cell proliferation in intestinal organoids to minimize proliferation fluctuations
Authors: Huelsz-Prince Guizela , Kok Rutger Nico Ulbe , Goos Yvonne , Bruens Lotte , Zheng Xuan , Ellenbroek Saskia , Van Rheenen Jacco , Tans Sander , van Zon Jeroen S
Published: November 2022

During renewal of the intestine, cells are continuously generated by proliferation. Proliferation and differentiation must be tightly balanced, as any bias toward proliferation results in uncontrolled exponential growth. Yet, the inherently stochastic nature of cells raises the question how such fluctuations are limited. We used time-lapse microscopy to track all cells in crypts of growing mouse intestinal organoids for multiple generations, allowing full reconstruction of the underlying lineage dynamics in space and time. Proliferative behavior was highly symmetric between sister cells, with both sisters either jointly ceasing or continuing proliferation. Simulations revealed that such symmetric proliferative behavior minimizes cell number fluctuations, explaining our observation that proliferating cell number remained constant even as crypts increased in size considerably. Proliferative symmetry did not reflect positional symmetry but rather lineage control through the mother cell. Our results indicate a concrete mechanism to balance proliferation and differentiation with minimal fluctuations that may be broadly relevant for other tissues.
Latent functional diversity may accelerate microbial community responses to temperature fluctuations
Authors: Smith Thomas P , Mombrikotb Shorok , Ransome Emma , Kontopoulos Dimitrios - Georgios , Pawar Samraat , Bell Thomas
Published: November 2022

How complex microbial communities respond to climatic fluctuations remains an open question. Due to their relatively short generation times and high functional diversity, microbial populations harbor great potential to respond as a community through a combination of strain-level phenotypic plasticity, adaptation, and species sorting. However, the relative importance of these mechanisms remains unclear. We conducted a laboratory experiment to investigate the degree to which bacterial communities can respond to changes in environmental temperature through a combination of phenotypic plasticity and species sorting alone. We grew replicate soil communities from a single location at six temperatures between 4°C and 50°C. We found that phylogenetically and functionally distinct communities emerge at each of these temperatures, with K-strategist taxa favored under cooler conditions and r-strategist taxa under warmer conditions. We show that this dynamic emergence of distinct communities across a wide range of temperatures (in essence, community-level adaptation) is driven by the resuscitation of latent functional diversity: the parent community harbors multiple strains pre-adapted to different temperatures that are able to ‘switch on’ at their preferred temperature without immigration or adaptation. Our findings suggest that microbial community function in nature is likely to respond rapidly to climatic temperature fluctuations through shifts in species composition by resuscitation of latent functional diversity.
Environmental morphing enables informed dispersal of the dandelion diaspore
Authors: Seale Madeleine , Zhdanov Oleksandr , Soons Merel B , Cummins Cathal , Kroll Erika , Blatt Michael R , Zare-Behtash Hossein , Busse Angela , Mastropaolo Enrico , Bullock James M , Viola Ignazio M , Nakayama Naomi
Published: November 2022

Animal migration is highly sensitised to environmental cues, but plant dispersal is considered largely passive. The common dandelion, Taraxacum officinale, bears an intricate haired pappus facilitating flight. The pappus enables the formation of a separated vortex ring during flight; however, the pappus structure is not static but reversibly changes shape by closing in response to moisture. We hypothesised that this leads to changed dispersal properties in response to environmental conditions. Using wind tunnel experiments for flow visualisation, particle image velocimetry, and flight tests, we characterised the fluid mechanics effects of the pappus morphing. We also modelled dispersal to understand the impact of pappus morphing on diaspore distribution. Pappus morphing dramatically alters the fluid mechanics of diaspore flight. We found that when the pappus closes in moist conditions, the drag coefficient decreases and thus the falling velocity is greatly increased. Detachment of diaspores from the parent plant also substantially decreases. The change in detachment when the pappus closes increases dispersal distances by reducing diaspore release when wind speeds are low. We propose that moisture-dependent pappus-morphing is a form of informed dispersal allowing rapid responses to changing conditions.
Conservation of oocyte development in germline cysts from Drosophila to mouse
Authors: Spradling Allan C , Niu Wanbao , Yin Qi , Pathak Madhulika , Maurya Bhawana
Published: November 2022

Recent studies show that pre-follicular mouse oogenesis takes place in germline cysts, highly conserved groups of oogonial cells connected by intercellular bridges that develop as nurse cells as well as an oocyte. Long studied in Drosophila and insect gametogenesis, female germline cysts acquire cytoskeletal polarity and traffic centrosomes and organelles between nurse cells and the oocyte to form the Balbiani body, a conserved marker of polarity. Mouse oocyte development and nurse cell dumping are supported by dynamic, cell-specific programs of germline gene expression. High levels of perinatal germ cell death in this species primarily result from programmed nurse cell turnover after transfer rather than defective oocyte production. The striking evolutionary conservation of early oogenesis mechanisms between distant animal groups strongly suggests that gametogenesis and early embryonic development in vertebrates and invertebrates share even more in common than currently believed.
Accidentally Confirmed Relapse of Plummer-Vinson Syndrome during Esophageal Foreign Body Evaluation
Authors: Kang Hye Jin , Kim Seong Hun , Seo Seung Young
Published: November 2022

Plummer-Vinson syndrome (PVS) is a complex condition characterized by a classic triad of dysphagia, iron deficiency anemia (IDA), and an upper esophageal web. Dysphagia represents the most important symptom of PVS and is usually observed with solid food. Therapeutic options for dysphagia include iron supplementation and/or endoscopic balloon dilation based on symptom severity. PVS can be treated easily and regular iron replacement therapy can prevent disease progression. We describe a 63-year-old woman diagnosed with a simple esophageal web, who underwent esophageal dilation 13 years prior to presentation. However, she revisited our center because of dysphagia secondary to an esophageal foreign body, and endoscopy revealed esophageal web relapse. Investigations revealed IDA, and the patient was eventually diagnosed as PVS. She underwent successful endoscopic dilation and denied recurrent dysphagia after continuous intake of iron tablets. We recommend continuous management of IDA, as well as endoscopic dilation and a multidisciplinary therapeutic approach to ensure favorable prognosis in PVS patients.
Comparison of the Effects of Oral Nizatidine versus Famotidine on Intragastric pH and Gastric Emptying in a Stress Rat Model
Authors: Yeom Dong Han , Choi Hyun Seok , Kim Min Seob , Yu Myeong Hwan , You Jisong , Lee Moon Young , Kim Yong Sung
Published: November 2022

Background/Aims: Histamine-2 receptor antagonists (H2RA) are used to treat acid-related disorders and functional dyspepsia. In contrast to other H2RAs, nizatidine promotes gastric emptying (GE). We investigated the effects of nizatidine and famotidine on intragastric pH and the GE rate in rats exposed to stress.Materials and Methods: We used 8-week-old male Wistar rats. Based on administration of water or drugs after an overnight fast, the animals were categorized into the nonstress-water, stress-water, stress-nizatidine, stress-famotidine, and stress-nizatidine with mosapride groups. The rats had access to pre-weighed food for 10 minutes, and those in the stress groups were exposed to 1 hour of restraint stress. Intragastric pH was measured under isoflurane anesthesia, and the GE rate was measured after the rats were sacrificed.Results: The GE rate was significantly lower in the stress-water and stress-famotidine groups than in the nonstress-water group. However, GE in the stress-nizatidine and stress-nizatidine with mosapride group did not significantly differ from that in the nonstress- water group. The GE rate was significantly higher in the stress-nizatidine with mosapride than in the stress-famotidine group. Intragastric pH was significantly higher in the stress-nizatidine and stress-famotidine groups than in the stress-water group. Nonetheless, there was no significant difference in pH between the stress-nizatidine and stress-famotidine groups. The intragastric pH was slightly but significantly higher in the stress-nizatidine with mosapride group than in the stress-nizatidine and stress-famotidine groups.Conclusions: In contrast to famotidine, nizatidine prevents stress-induced GE delay, which suggests that nizatidine is superior to other H2RAs for treatment of functional dyspepsia associated with delayed GE.
Anatomy and behavior of Laternula elliptica, a keystone species of the Antarctic benthos (Bivalvia: Anomalodesmata: Laternulidae)
Authors: Passos Flávio Dias , Sartori André Fernando , Domaneschi Osmar , Bieler Rüdiger
Published: November 2022

Laternula elliptica (P. P. King, 1832) is the sole representative of the anomalodesmatan family Laternulidae and the largest bivalve in the Antarctic and Subantarctic. A keystone species of the regional benthic communities, it has reached model status, having been studied in hundreds of scientific works across many biological disciplines. In contrast, its anatomy has remained poorly known, with prior published data limited to partial descriptions based on chemically preserved specimens. Based on observations of aquarium-maintained living animals at the Brazilian Comandante Ferraz Antarctic Station, gross-morphological dissections, and histological sectioning, the comparative anatomy, functional morphology, and aspects of behavior of L. elliptica are described and discussed. Special focus is placed on the pallial organs (including elucidation of cleansing and feeding sorting mechanisms in the mantle cavity) and the musculature. Among the noteworthy findings are the presence of well-developed siphons furnished with sensory tentacles at its tips, some of which bearing eyes; large, folded gills and labial palps capable of sorting the material entering the mantle cavity; an inter-chamber communication in the posterior region of the mantle cavity; an ample ventral mantle fusion with an anterior pedal gape; the absence of a 4th pallial opening; and the absence of a ligamental lithodesma in adult specimens. This study reevaluates the available anatomical data in the literature, both supplementing and correcting previously published accounts.
The morphology of the pulp chamber floor of permanent mandibular first and second molars in an Indian subpopulation—a descriptive cross-sectional study employing Pawar and Singh classification
Authors: Pawar Ajinkya M. , Singh Shishir
Published: November 2022

Background

Mandibular molars are multi-rooted teeth with a complex and strenuous root canal anatomy. Because there is relatively negligible literature describing the pulp chamber floor anatomy, predicting the exact anatomical layout and its variations is daunting. A thorough comprehension and knowledge of the same is required for efficacious endodontic treatment consequence. The purpose of this study was to characterise and ascertain the pulp chamber floor anatomy of permanent mandibular first (ManFMs) and second (ManSMs) molars in an Indian population.

Methods

On 2,134 extracted human mandibular first (ManFMs = 1,067) and second molars (ManSMs = 1,067), a descriptive cross-sectional investigation was executed. Cleaning and removal of hard and soft tissue debris were performed, followed by flattening the anatomical crown until the pupal architecture was uncovered. A stereomicroscope with a magnification of 4.5 magnification was used to investigate the pulpal anatomy. Statistical analysis was carried out using chi square test, with 95% confidence intervals and apvalue of 0.05 considered statistically significant.

Results

The majority of the ManFMs showed presence of three canal orifices in 57.73%, followed by four orifices 31.31%, five orifices 8.81%, and six orifices 2.15%. For ManSMs, majorly three orifices were found in 39.83% specimens, followed by two orifices in 37.39%, four orifices in 16.31%, and single root canal orifice was observed in 6.47%. The mesio-buccal, mesio-lingual, disto-buccal, disto-lingual canal orifices exhibited round and oval shapes in both ManFMs and ManSMs. The shape was predominantly oval with a single distal canal orifice (84.25% ManFMs and 74.16% ManSMs). In ManSMs, among the single root canal orifice, 66.66% were round in shape and 33.34% were C-shaped. In ManSMs with two root canal orifices, mesially 79.44% exhibited oval and 20.56% round shape. Distally, 74.16% were oval and 25.84% were round. The shapes of the access cavities for ManFMs were rectangular in 46.67% and triangular in 53.33%. For the ManSMs, the access cavities were triangular in 39.83%, rectangular in 16.31% and non-classified (others) in 43.86% of specimen. In both ManFMs and ManSMs, the pulp chamber floor morphology was predominately Y shaped (57.73% and 39.83%) according to the Pawar and Singh classification© of pulp chamber floor anatomy.

Conclusion

Our study indicated that the orifices on the pulp chamber floor are arranged in a typical manner, supporting the proposed categorization. Furthermore, description of the anatomical patterns of the pulp chamber guides the clinicians in chair-side treatment decisions.
The evolution of unique cranial traits in leporid lagomorphs
Authors: Wood-Bailey Amber P. , Cox Philip G. , Sharp Alana C.
Published: November 2022

Background

The leporid lagomorphs (rabbits and hares) are adapted to running and leaping (some more than others) and consequently have unique anatomical features that distinguish them from ochotonid lagomorphs (pikas) and from their rodent relatives. Two traits that have received some attention are fenestration of the lateral wall of the maxilla and facial tilting. These features are known to correlate with specialised locomotory form in that the faster running species will generally have fenestration that occupies the dorsal and the anteroventral surface of the maxillary corpus and a more acute facial tilt angle. Another feature is an intracranial joint that circumscribes the back of the skull, thought to facilitate skull mobility. This joint separates the anterior portion of the cranium (including the dentition, rostrum and orbit) from the posterior portion of the cranium (which encompasses the occipital and the auditory complex). Aside from the observation that the intracranial joint is absent in pikas (generalist locomotors) and appears more elaborate in genera with cursorial and saltatorial locomotory habits, the evolutionary history, biomechanical function and comparative anatomy of this feature in leporids lacks a comprehensive evaluation.

Methodology

The present work analysed the intracranial joint, facial tilting and lateral fenestration of the wall of the maxilla in the context of leporid evolutionary history using a Bayesian inference of phylogeny (18 genera, 23 species) and ancestral state reconstruction. These methods were used to gather information about the likelihood of the presence of these three traits in ancestral groups.

Results

Our phylogenetic analyses found it likely that the last common ancestor of living leporids had some facial tilting, but that the last common ancestor of all lagomorphs included in the dataset did not. We found that it was likely that the last common ancestor of living leporids had fenestration that occupies the dorsal, but not the anteroventral, surface of the maxillary corpus. We also found it likely that the last common ancestor of living leporids had an intracranial joint, but that the last common ancestor of all living lagomorphs did not. These findings provide a broader context to further studies of evolutionary history and will help inform the formulation and testing of functional hypotheses.
Multivalent forms of the ribonuclease H1 hybrid binding domain are high‐affinity binders of RNA–DNA hybrids
Authors: Stopar Alex , Nicholson Allen W.
Published: November 2022

The hybrid binding domain (HBD) is a conserved fold present in ribonucleases H1 that selectively recognizes RNA–DNA hybrids, which are structures present in cellular R‐loops and participate in diverse biological processes. We engineered multivalent HBD proteins to create high‐affinity hybrid binders. Using EMSA‐ and SPR‐based analyses, we showed that the triple‐HBD protein exhibits a ~ 22 000‐fold increase in hybrid affinity (KD 370 pm) relative to the single HBD (KD 8.29 μm), with the length and sequence of the linkers enabling optimal function. These findings provide a framework for testing models that correlate multivalency and affinity to understand how multivalent proteins function and also can serve to guide applications that exploit multivalency as a strategy to enhance binding affinity.
On the Independent Roles of Cognitive & Political Sophistication: Variation Across Attitudinal Objects
Authors: Vitriol Joseph A. , Sandor Joseph , Vidigal Robert , Farhart Christina
Published: November 2022

People are motivated to maintain consistency between importantly held identities, preferences, and judgments. In political contexts, motivated reasoning can help explain a wide range of political phenomena, including extremism, polarization, and misperceptions. However, recent findings in psychology have challenged this account. These perspectives emphasize the role of cognitive sophistication (e.g., analytical reasoning, numerical literacy) in political attitudes, but differ in terms of whether it is expected to attenuate or exacerbate politically motivated reasoning and belief in conspiracy theories. Yet prior investigations have not examined the relative and independent effects of both political and cognitive sophistication. Using data from two samples, including one sampled to approximate representativeness in the U.S., we demonstrate that both types of sophistication have independent and (at times) countervailing effects on belief in COVID‐19 conspiracy theories and other political attitudes. Our results are critical for theories of cognitive sophistication, political cognition, and attitudes, and the psychology of conspiracy theories.
Recursive identification of a nonlinear state space model
Authors: Wigren Torbjörn
Published: November 2022

The convergence of a recursive prediction error method is analyzed. The algorithm identifies a nonlinear continuous time state space model, parameterized by one right‐hand side component of the differential equation and an output equation with a fixed differential gain, to avoid over‐parametrization. The method minimizes the criterion by simulation using an Euler discretization. A stability analysis of the associated differential equations results in conditions for (local) convergence to a minimum of the criterion function. Simulations verify the theoretical analysis and illustrate the performance in the presence of unmodeled dynamics, by identification of the nonlinear drum boiler dynamics of a power plant model.
Model‐free hierarchical control with fractional‐order sliding surface for multisection web machines
Authors: Dang Van Trong , Nguyen Dinh Bao Hung , Tran Thi Dieu Trinh , Le Duc Thinh , Nguyen Tung Lam
Published: November 2022

Due to the nonlinearities and dynamical properties of multisection web machines, it is essential to accomplish an appropriate mathematical model as well as design a compatible control scheme. A generalized fully driven web winding model is constructed taking unpredictable changes of moment of inertia and radius of rolls into consideration. In this article, a fractional‐order sliding surface algorithm‐based hierarchical control frame is applied to multisection web machines to deal with matched and mismatched uncertainties and disturbances. In addition, the Radius Basis Function neural network is deployed to estimate necessary system dynamics and the proposed control scheme taking advantage of first‐order low‐pass filters to produce virtual control signals without complicated calculation and attenuate the explosion of terms phenomenon. Finally, the semi‐global stability of the entire system is determined using Lyapunov's stability theory. The simulation results are presented to clarify the superior performance of robust control algorithm and approximation law in the presence of nonideal elements.
Extracellular Matrix Secretion Mechanically Reinforces Interlocking Interfaces
Authors: McCarthy Alec , Sharma Navatha Shree , Holubeck Phil A. , Brown Demi , Shah Rajesh , McGoldrick Daniel , John Johnson V. , Shahriar S. M. Shatil , Xie Jingwei
Published: November 2022

Drawing inspiration for biomaterials from biological systems has led to many biomedical innovations. One notable bioinspired device, Velcro, consists of two substrates with interlocking ability. Generating reversibly interlocking biomaterials is an area of investigation, as such devices can allow for modular tissue engineering, reversibly interlocking biomaterial interfaces, or friction‐based coupling devices. Here, a biaxially interlocking interface generated using electrostatic flocking is reported. Two electrostatically flocked substrates are mechanically and reversibly interlocked with the ability to resist shearing and compression forces. An initial high‐throughput screen of polyamide flock fibers with varying diameters and fiber lengths is conducted to elucidate the roles of different fiber parameters on scaffold mechanical properties. After determining the most desirable parameters via weight scoring, polylactic acid (PLA) fibers are used to emulate the ideal scaffold for in vitro use. PLA flocked scaffolds are populated with osteoblasts and interlocked. Interlocked flocked scaffolds improved cell survivorship under mechanical compression and sustained cell viability and proliferation. Additionally, the compression and shearing resistance of cell‐seeded interlocking interfaces increased with increasing extracellular matrix deposition. The introduction of extracellular matrix‐reinforced interlocking interfaces may serve as binders for modular tissue engineering, act as scaffolds for engineering tissue interfaces, or enable friction‐based couplers for biomedical applications.
Meniscus‐Guided Micro‐Printing of Prussian Blue for Smart Electrochromic Display
Authors: Kim Je Hyeong , Park Seobin , Ahn Jinhyuck , Pyo Jaeyeon , Kim Hayeol , Kim Namhun , Jung Im Doo , Seol Seung Kwon
Published: November 2022

Using energy‐saving electrochromic (EC) displays in smart devices for augmented reality makes cost‐effective, easily producible, and efficiently operable devices for specific applications possible. Prussian blue (PB) is a metal‐organic coordinated compound with unique EC properties that limit EC display applications due to the difficulty in PB micro‐patterning. This work presents a novel micro‐printing strategy for PB patterns using localized crystallization of FeFe(CN)6 on a substrate confined by the acidic‐ferric‐ferricyanide ink meniscus, followed by thermal reduction at 120 °C, thereby forming PB. Uniform PB patterns can be obtained by manipulating printing parameters, such as the concentration of FeCl3·K3Fe(CN)6, printing speed, and pipette inner diameter. Using a 0.1 M KCl (pH 4) electrolyte, the printed PB pattern is consistently and reversibly converted to Prussian white (CV potential range: −0.2–0.5 V) with 200 CV cycles. The PB‐based EC display with a navigation function integrated into a smart contact lens is able to display directions to a destination to a user by receiving GPS coordinates in real time. This facile method for forming PB micro‐patterns could be used for advanced EC displays and various functional devices.
Comparison of aliphatic polyesters prepared by acyclic diene metathesis and thiol‐ene polymerization of α,ω‐polyenes arising from oleic acid‐based 9‐decen‐1‐ol
Authors: Moser Bryan R. , Doll Kenneth M. , Price Neil P. J.
Published: November 2022

Development of more sustainable and environmentally friendly polymers as alternatives to petroleum‐based polymers is a priority. We report the synthesis of six linear, aliphatic, renewable polymers by acyclic diene metathesis (ADMET) and thiol‐ene polymerization of α,ω‐polyenes resulting from thermal esterification of adipic, azelaic, and itaconic acids with 9‐decen‐1‐ol. ADMET homopolymerization was performed with 1.0 mol% Hoveyda–Grubbs second generation metathesis catalyst. Thiol‐ene copolymerization was conducted photochemically with 1 wt% 2,2‐dimethoxy‐2‐phenyl‐acetophenone and stoichiometric 1,2‐ethanedithiol (EDT). Although the thiol‐ene copolymers exhibited carbon and atom economies of 100%, the ADMET‐derived polyesters possessed superior renewable carbon content (100%) and environmental factors (<4). These results were attributed to incorporation of non‐renewable EDT into poly(thioether‐ester)s and loss of ethene during production of ADMET polyesters. The Mn (>26 kDa), Mw (>92 kDa), and dispersities (>3.4) of the poly(thioether‐ester)s were higher than the corresponding polyesters, which in part explained why the poly(thioether‐ester)s gave higher melting (>61°C), crystallization (>49°C) and glass transition (>−31°C) temperatures. The cross‐linked itaconate polymers did not melt or crystallize, thereby suggesting amorphous morphology. Lastly, the ADMET polyesters were more thermally stable (T50 > 408°C) than the poly(thioether‐ester)s (T50 < 377°C). In summary, the aliphatic biopolymers displayed a wide range of properties that were impacted by polymerization method as well as the nature of the monomer.
Optimal control strategy by tracking and compensation for ICPS under the DoS attack
Authors: Sun Ziwen , Qin Yanfei , Xue Weifeng , Zhuang Kangxi , Lu Xianling
Published: November 2022

To solve the security problem of industrial cyber‐physical systems (ICPS) suffering from the Denial of Service (DoS) attack, this paper proposes an optimal control strategy with functions of tracking and compensation control. The system model, being depicted as a discrete linear time‐invariant system combined with an improved Bernoulli model, is established to describe the system under DoS attacks by using the feedback control theory. The optimal control strategy is completed by designing linear quadratic Gaussian (LQG) controller consisting of a tracking regulator and a Kalman filter to achieve tracking control of ICPS whose equilibrium state is neither zero state nor zero output, where a periodic event‐triggered mechanism is adopted for ensuring the system's stability. The compensation control strategy is completed by designing a compensator to compensate the system to a certain extent through the multistep state prediction compensation strategy after a DoS attack being detected, where the detector is adopted to detect the DoS attack based on the measurement residual obtained by the Kalman filter. The simulation test is conducted by using Simulink/True Time tool with a ball‐beam system as the physical object, whose results show that the tracking regulator can achieve the tracking control of ICPS; compensation strategy can reduce the impact of the attack on the system to a certain extent.
Nuclei and tracts in the pretectum and associated tegmentum of crocodiles
Authors: Pritz Michael B.
Published: November 2022

In all vertebrates, the pretectum and associated tegmentum arise from prosomere 1, but the adult derivatives of these embryonic regions are not well defined in reptiles—especially in crocodiles, the reptilian group most closely related to birds. Despite its importance in vision and visuomotor behavior, descriptions of the pretectum in crocodiles are brief and photographs are lacking. To fill this gap in knowledge, the pretectum and associated tegmentum were examined in two crocodilians, Caiman crocodilus and Alligator mississippiensis, using a variety of histological stains in all three traditional planes of section. These observations were compared with similar studies in other reptiles and birds. These comparisons were hampered by differences in nomenclature and limited data. Nevertheless, pretectal nuclei in receipt of retinal input in crocodiles, other reptiles, and birds were the most easily identified when compared with the present analysis. Despite identifying the traditional nuclei comprising the pretectum of crocodiles, other areas remain to be characterized. Nevertheless, knowledge gained from this description will aid further investigations of this brain region in crocodiles and other reptiles as well as provide a reference for developmental studies in crocodiles.