bluuebunny/crossref_metadata_2025 huggingface dataset:
Discussing the posthosting evaluation of a mega sporting event: The perception of Warsaw Residents toward UEFA EURO 2012
Authors: Garbacz Justyna , Cadima Ribeiro J , Mourão Paulo Reis
Published: April 2016

The aim of this paper is to identify Warsaw residents’ perceptions and attitudes toward the UEFA EURO 2012 tournament. The investigation focused on how residents of Warsaw perceived the impacts of the tournament one year after the event. A questionnaire survey was applied using a stratified sampling method to 480 residents of Warsaw. The results of the survey and ordered logit regressions show that although the residents did not perceive that the economic benefits of the tournament were spread uniformly, a large majority valued the tournament’s role in promoting Warsaw as a tourist destination and enhancing the international identity of the city. Whereas residents generally displayed positive attitudes toward EURO 2012 in terms of lifting their pride and bringing the community closer together, they also noted some negative impacts of the event. The opinions expressed about the tournament depended on the age, education, and income of the responders. A majority of the residents agreed that the positive impacts of EURO 2012 outweighed the negative.
The Impact on Informal Supporters of Domestic Violence Survivors: A Systematic Literature Review
Authors: Gregory Alison Clare , Williamson Emma , Feder Gene
Published: April 2016

Domestic violence (DV) is experienced by 1 in 4 women in the United Kingdom during their lifetime, and most survivors will seek informal support from the people around them, even if they choose not to access help from professionals. Support from these relatives, friends, neighbors, and colleagues can provide a buffer against effects on the survivor’s physical health, mental health, and quality of life, and has been shown to be protective against future abuse. There has been an absence of research studying members of survivors’ networks and, in particular, investigating how the impact of DV might diffuse to affect them. A systematic literature review of reported research (either in peer-reviewed journals or in gray literature) was undertaken to explore the impacts of DV on survivor networks. Of the articles found, 24 had data relating to the topic area, though no study addressed the question directly. Framework analysis and meta-ethnography generated the following themes: physical health impacts, negative impacts on psychological well-being, direct impacts from the perpetrator, and beneficial impacts on psychological well-being. The studies in this review indicated that informal supporters may be experiencing substantial impact, including vicarious trauma and the risk of physical harm. Currently, there is little support available which is directly aimed at informal supporters of DV survivors, thus these findings have practical and policy implications, in order to acknowledge and meet their needs.
The development and optimisation of a primary care-based whole system complex intervention (CARE Plus) for patients with multimorbidity living in areas of high socioeconomic deprivation
Authors: Mercer Stewart William , O'Brien Rosaleen , Fitzpatrick Bridie , Higgins Maria , Guthrie Bruce , Watt Graham , Wyke Sally
Published: April 2016

Objectives

To develop and optimise a primary care-based complex intervention (CARE Plus) to enhance the quality of life of patients with multimorbidity in the deprived areas.

Methods

Six co-design discussion groups involving 32 participants were held separately with multimorbid patients from the deprived areas, voluntary organisations, general practitioners and practice nurses working in the deprived areas. This was followed by piloting in two practices and further optimisation based on interviews with 11 general practitioners, 2 practice nurses and 6 participating multimorbid patients.

Results

Participants endorsed the need for longer consultations, relational continuity and a holistic approach. All felt that training and support of the health care staff was important. Most participants welcomed the idea of additional self-management support, though some practitioners were dubious about whether patients would use it. The pilot study led to changes including a revised care plan, the inclusion of mindfulness-based stress reduction techniques in the support of practitioners and patients, and the stream-lining of the written self-management support material for patients.

Discussion

We have co-designed and optimised an augmented primary care intervention involving a whole-system approach to enhance quality of life in multimorbid patients living in the deprived areas. CARE Plus will next be tested in a phase 2 cluster randomised controlled trial.
Control authority over a combustion instability investigated in CFD
Authors: Müller Roel AJ , Hermann Jakob , Polifke Wolfgang
Published: April 2016

Control authority is investigated for active damping of a combustion instability by modulation of the fuel flow. Two combustors, operating as quarter-wave thermo-acoustic oscillators, are modelled in ANSYS CFX. In experiments, active damping was applied successfully on one of these, but was not effective on the other. Active instability control is implemented in the model analogous to experiment. The goal of this research is to explain why the same implementation of active instability control, using the same controller, would be effective on one combustor geometry, but not on the other. Turbulent combustion is modelled by SAS-SST and the burning velocity model. The distribution of the convective time between fuel injector and flame is evaluated and used to estimate the response of the heat release to modulation of the fuel mass flow. The results can be used to predict the feasibility of this kind of active control.
The impact of prophylactic pancreatic stenting on post‐ERCP pancreatitis: A nationwide, register‐based study
Authors: Olsson Greger , Lübbe Jeanne , Arnelo Urban , Jonas Eduard , Törnqvist Björn , Lundell Lars , Enochsson Lars
Published: April 2016

Background and objectives

The role of prophylactic pancreatic stenting (PS) in preventing post‐endoscopic retrograde cholangio‐pancreatography (ERCP) pancreatitis (PEP) has yet to be determined. Most previous studies show beneficial effects in reducing PEP when prophylactic pancreatic stents are used, especially in high‐risk ERCP procedures. The present study aimed to address the use of PS in a nationwide register‐based study in which the primary outcome was the prophylactic effect of PS in reducing PEP.

Methods

All ERCP‐procedures registered in the nationwide Swedish Registry for Gallstone Surgery and ERCP (GallRiks) between 2006 and 2014 were studied. The primary outcome was PEP but we also studied other peri‐ and postoperative complication rates.

Results

Data from 43,595 ERCP procedures were analyzed. In the subgroup of patients who received PS with a total diameter ≤ 5 Fr, the risk of PEP increased nearly four times compared to those who received PS with a total diameter of >5 Fr (OR 3.58; 95% CI 1.40–11.07). Furthermore, patients who received PS of >5 Fr and >5 cm had a significantly lower pancreatitis frequency compared to those with shorter stents of the same diameter (1.39% vs 15.79%; p  = 0.0033).

Conclusions

PS with a diameter of >5 Fr and a length of >5 cm seems to have a better protective effect against PEP, compared to shorter and thinner stents. However, in the present version of GallRiks it is not possible to differentiate the exact type of pancreatic stent (apart from material, length and diameter) that has been introduced, so our conclusion must be interpreted with caution.
Phenotypic, transcriptomic, and genomic features of clonal plasma cells in light-chain amyloidosis
Authors: Paiva Bruno , Martinez-Lopez Joaquin , Corchete Luis A. , Sanchez-Vega Beatriz , Rapado Inmaculada , Puig Noemi , Barrio Santiago , Sanchez Maria-Luz , Alignani Diego , Lasa Marta , García de Coca Alfonso , Pardal Emilia , Oriol Alberto , Garcia Maria-Esther Gonzalez , Escalante Fernando , González-López Tomás J. , Palomera Luis , Alonso José , Prosper Felipe , Orfao Alberto , Vidriales Maria-Belen , Mateos María-Victoria , Lahuerta Juan-Jose , Gutierrez Norma C. , San Miguel Jesús F.
Published: April 2016

Key Points

Clonal PCs in AL have similar phenotypic and CNA profiles as those in MM, but their transcriptome is similar to that of normal PCs. First-ever WES in AL amyloidosis reveals potential lack of a unifying mutation.
The RP105/MD-1 complex: molecular signaling mechanisms and pathophysiological implications
Authors: Schultz Thomas E , Blumenthal Antje
Published: April 2016

Radioprotective 105 kDa (CD180) is an unusual TLR that lacks an intracellular Toll-IL-1R signaling domain and exhibits unconventional homodimerization behavior. Differential expression and functions of radioprotective 105 kDa have been associated with immune-mediated pathologies, including infection, chronic inflammation, and autoimmune disorders. Radioprotective 105 kDa activates macrophages and B cells independently of canonical TLR signaling. Current understanding of the functional consequences of radioprotective 105 kDa signaling in B cells, macrophages, and dendritic cells indicates overlapping, but also some apparent opposing, cell-specific roles for radioprotective 105 kDa in shaping cellular functions. This review compares interactions of radioprotective 105 kDa with its coreceptors, CD19, TLR4, and TLR2; integrates recent, novel findings on radioprotective 105 kDa-mediated molecular signaling mechanisms; and summarizes current understanding of its contributions to infectious, inflammatory, and autoimmune disease.
Biomarker Tests for Molecularly Targeted Therapies: Laying the Foundation and Fulfilling the Dream
Authors: Lyman Gary H. , Moses Harold L.
Published: April 2016

Precision medicine focuses on the management of individual patients on the basis of biomarkers and other distinguishing characteristics, with the overarching objective of improving clinical outcomes. The rapid proliferation of biomarker tests and targeted therapies has revolutionized patient care in a variety of serious disorders. Targeted cancer therapies interrupt oncogenic molecular pathways driven by mutations, overexpression, or translocation of specific genes. However, there is concern that the emergence of large-scale genomic data is exceeding our capacity to appropriately analyze and interpret the results.

In 2014, the Institute of Medicine convened the Committee on Policy Issues in the Clinical Development and Use of Biomarkers for Molecularly Targeted Therapies. This committee conducted a study to develop recommendations to address diverse and interconnected development, regulatory, clinical practice, and reimbursement issues. The committee conducted an extensive search of the relevant literature and invited testimony from a wide range of experts in the field. The final report of the committee’s study and deliberations was released on March 4, 2016, focusing on ways to achieve 10 goals to further advance the development and appropriate clinical use of biomarker tests for molecularly targeted therapies.

This article presents an overview of the committee’s study and resulting recommendations, which cover establishment of clinical utility, regulatory oversight, coverage and reimbursement, health system data integration, as well as education and access. The committee’s recommendations presented and discussed here are fundamentally grounded in the understanding that, when properly validated and appropriately implemented, these assays and corresponding therapies hold considerable promise to enhance the quality of patient care and improve meaningful clinical outcomes.
Feasibility Study of an Electronic Interface Between Internet-Based Survivorship Care Plans and Electronic Medical Records
Authors: Hill-Kayser Christine E. , Jacobs Linda A. , Gabriel Peter , Palmer Steven C. , Hampshire Margaret K. , Vachani Carolyn , Edge Stephen B. , Metz James M.
Published: April 2016

Purpose:

Survivorship care plans (SCPs) are recommended for all cancer survivors. Myriad barriers to implementation exist. This study was performed to evaluate the feasibility of interface development between an SCP and an electronic medical record (EMR).

Methods:

An information technology application was developed to extract data from the EMR in use at our center (Epic). Data were transferred to autopopulate an Internet-based tool for creation of SCPs (LIVESTRONG Care Plan) that had been previously used for the creation of more than 35,000 plans.

Results:

Data (demographic characteristics, surgeries, chemotherapy drugs, radiation site) were extracted from the EMR and transferred to the care plan platform, without transfer of protected health information. Care plans were created and transferred back to the EMR. During clinical testing, SCPs were created by nurse practitioners during scheduled clinic visits for 146 sequential, eligible patients (67% breast cancer, 33% colorectal cancer). All patients received completed care for a single cancer diagnosis at our institution. All data points that were automatically populated were reviewed by practitioners, and missing/blank data fields were populated manually when necessary. Data entered into generated care plans were accurate in 97% of audited cases, and the process of care plan generation could be completed in < 1 minute.

Conclusion:

This is a feasible solution for the autopopulation of SCPs from the EMR. It represents a future methodology through which widespread implementation of SCPs may be undertaken. Future directions include further clinical testing, assessment of provider-perceived usefulness, and integration into routine clinical care.
Low Enrollment of Adolescents and Young Adults Onto Cancer Trials: Insights From the Community Clinical Oncology Program
Authors: Roth Michael E. , O’Mara Ann M. , Seibel Nita L. , Dickens David S. , Langevin Anne-Marie , Pollock Brad H. , Freyer David R.
Published: April 2016

Purpose:

Stagnant outcomes for adolescents and young adults (AYAs; 15 to 39 years old) with cancer are partly attributed to poor enrollment onto clinical trials. The National Cancer Institute (NCI) Community Clinical Oncology Program (CCOP) was developed to improve clinical trial participation in the community setting, where AYAs are most often treated. Further, many CCOP sites had pediatric and medical oncologists with collaborative potential for AYA recruitment and care. For these reasons, we hypothesized that CCOP sites enrolled proportionately more AYAs than non-CCOP sites onto Children’s Oncology Group (COG) trials.

Methods:

For the 10-year period 2004 through 2013, the NCI Division of Cancer Prevention database was queried to evaluate enrollments into relevant COG studies. The proportional enrollment of AYAs at CCOP and non-CCOP sites was compared and the change in AYA enrollment patterns assessed. All sites were COG member institutions.

Results:

Although CCOP sites enrolled a higher proportion of patients in cancer control studies than non-CCOP sites (3.5% v 1.8%; P < .001), they enrolled a lower proportion of AYAs (24.1% v 28.2%, respectively; P < .001). Proportional AYA enrollment at CCOP sites decreased during the intervals 2004 through 2008 and 2009 through 2013 (26.7% v 21.7%; P < .001).

Conclusion:

Despite oncology practice settings that might be expected to achieve otherwise, CCOP sites did not enroll a larger proportion of AYAs in clinical trials than traditional COG institutions. Our findings suggest that the CCOP (now the NCI Community Oncology Research Program) can be leveraged for developing targeted interventions for overcoming AYA enrollment barriers.
Understanding and Managing Erectile Dysfunction in Patients Treated for Cancer
Authors: Voznesensky Maria , Annam Kiran , Kreder Karl J.
Published: April 2016

Cancer can cause sexual adverse effects by direct and indirect pathways. It can involve sexual organs, indirectly affect body image, or cause fatigue or depression with subsequent effects on libido. Erectile dysfunction (ED), the inability to obtain or maintain an erection firm enough for sexual intercourse, can also result from adverse effects of cancer treatment, such as fatigue, pain, or anxiety about therapy. In addition, depressed feelings about having cancer can affect sexuality, causing a range of signs and symptoms that can lead to ED. Chemotherapy, hormone therapy, surgery, and radiation can all cause sexual adverse effects. Additional factors that play a role include patient age and degree of ED before starting cancer treatment. In this article, we discuss how chemotherapy, hormone therapy, surgery, and radiation affect erectile function as well as possible treatment options for ED.
Characterization of Chicken Thyroid Hormone Transporters
Authors: Bourgeois Nele M. A. , Van Herck Stijn L. J. , Vancamp Pieter , Delbaere Joke , Zevenbergen Chantal , Kersseboom Simone , Darras Veerle M. , Visser Theo J.
Published: April 2016

Thyroid hormone (TH) transmembrane transporters are key regulators of TH availability in target cells where correct TH signaling is essential for normal development. Although the chicken embryo is a valuable model for developmental studies, the only functionally characterized chicken TH transporter so far is the organic anion transporting polypeptide 1C1 (OATP1C1). We therefore cloned the chicken L-type amino acid transporter 1 (LAT1) and the monocarboxylate transporters 8 (MCT8) and 10 (MCT10), and functionally characterized them, together with OATP1C1, in JEG3, COS1, and DF-1 cells. In addition, we used in situ hybridization to study their mRNA expression pattern during development. MCT8 and OATP1C1 are both high affinity transporters for the prohormone T4, whereas receptor-active T3 is preferably transported by MCT8 and MCT10. The latter one shows lower affinity but has a high Vmax and seems to be especially good at T3 export. Also, LAT1 has a lower affinity for its preferred substrate 3,3′-diiodothyronine. Reverse T3 is transported by all 4 TH transporters and is a good export product for OATP1C1. TH transporters are strongly expressed in eye (LAT1, MCT8, MCT10), pancreas (LAT1, MCT10), kidney, and testis (MCT8). Their extensive expression in the central nervous system, especially at the brain barriers, indicates an important role in brain development. In conclusion, we show TH transport by chicken MCT8, MCT10, and LAT1. Together with OATP1C1, these transporters have functional characteristics similar to their mammalian orthologs and are interesting target genes to further elucidate the role of THs during embryonic development.
Tissue- and stage-specific Wnt target gene expression is controlled subsequent to β‑catenin recruitment
Authors: Nakamura Yukio , de Paiva Alves Eduardo , Veenstra Gert Jan , Hoppler Stefan
Published: April 2016

Developmental signalling pathways operate repeatedly to regulate remarkably tissue- and stage-specific transcriptional responses. Canonical Wnt/β‑catenin signalling is such a key developmental pathway; however, while recruitment of nuclear β-catenin to target genomic loci serves as the hallmark of canonical Wnt signalling, mechanisms controlling context-specific transcriptional responses in different stages and tissues remain elusive. Here using the first direct comparison of genome-wide occupancy of β‑catenin with a stage-matched Wnt-regulated transcriptome in early vertebrate embryos, we discover that just a subset of β‑catenin-bound genomic loci are transcriptionally regulated by Wnt signalling. We further demonstrate that Wnt signalling regulates β‑catenin binding to Wnt target genes not only in the developmental context in which they are transcriptionally regulated, but also in other contexts, where their transcription remains unaffected. Their transcriptional response to Wnt signalling is conditional on additional mechanisms, such as BMP or FGF signalling for the particular genes we investigated, which, however, do not influence β‑catenin recruitment. In conclusion, our findings suggest a more general paradigm for Wnt-regulated transcriptional mechanisms, which is relevant for the repeated and tissue-specific functions of Wnt/β‑catenin signalling particularly in embryonic development, but also for stem-cell-mediated homeostasis and cancer. Chromatin-association of β‑catenin, even to functional Wnt response elements, can no longer be considered a proxy for identifying transcriptional Wnt target genes. Context-dependent mechanisms are crucial for transcriptional activation of Wnt/β‑catenin target genes subsequent to β‑catenin recruitment. Our conclusions therefore imply that Wnt-regulated β‑catenin binding in one context can mark Wnt-regulated transcriptional target genes for different contexts.
Thyroid follicle development requires Smad1/Smad5- and endothelial-dependent basement membrane assembly
Authors: Villacorte Mylah , Delmarcelle Anne-Sophie , Lernoux Manon , Bouquet Mahé , Lemoine Pascale , Bolsée Jennifer , Umans Lieve , de Sousa Lopes Susana Chuva , Van Der Smissen Patrick , Sasaki Takako , Bommer Guido , Henriet Patrick , Refetoff Samuel , Lemaigre Frédéric P. , Zwijsen An , Courtoy Pierre J. , Pierreux Christophe E.
Published: April 2016

Thyroid follicles, the functional units of the thyroid gland, are delineated by a monolayer of thyrocytes resting on a continuous basement membrane. Developmental mechanisms whereby follicles are formed by reorganization of a non-structured mass of non-polarized epithelial cells (folliculogenesis) largely unknown. Here we show that assembly of the epithelial basement membrane is critical for folliculogenesis and is controlled by endothelial cell invasion and by BMP-Smad signaling in thyrocytes. Thyroid-specific double Smad1 and Smad5 knockout mice (Smad1/5dKO) displayed growth retardation, hypothyroidism and defective follicular architecture. In Smad1/5dKO embryonic thyroids, epithelial cells remained associated in large clusters and formed small follicles. Although similar follicular defects are found in VegfaKO thyroids, Smad1/5dKO thyroids had normal endothelial cell density yet impaired endothelial differentiation. Interestingly, both VegfaKO and Smad1/5dKO thyroids displayed impaired basement membrane assembly. Furthemore, conditioned medium (CM) from embryonic endothelial progenitor cells (eEPC) rescued the folliculogenic defects of both Smad1/5dKO and VegfaKO thyroids. Laminin α1β1γ1, abundantly released by eEPC into CM, was critically required for folliculogenesis. Thus, epithelial Smad signaling and endothelial cell invasion promote folliculogenesis via assembly of the basement membrane.
Nuclear transport of paxillin depends on focal adhesion dynamics and FAT domains
Authors: Sathe Aneesh R. , Shivashankar G. V. , Sheetz Michael P.
Published: April 2016

The nuclear transport of paxillin appears to be crucial for paxillin function but the mechanism of transport remains unclear. Here, we show that the nuclear transport of paxillin is regulated by focal adhesion turnover and the presence of FAT domains. Focal adhesion turnover was controlled using triangular or circular fibronectin islands. Circular islands caused higher focal adhesion turnover and increased the nuclear transport of paxillin relative to triangular islands. Mutating several residues of paxillin had no effect on its nuclear transport, suggesting that the process is controlled by multiple domains. Knocking out FAK (also known as PTK2) and vinculin caused an increase in nuclear paxillin. This could be reversed by rescue with wild-type FAK but not by FAK with a mutated FAT domain, which inhibits paxillin binding. Expressing just the FAT domain of FAK not only brought down nuclear levels of paxillin but also caused a large immobile fraction of paxillin to be present at focal adhesions, as demonstrated by fluorescence recovery after photobleaching (FRAP) studies. Taken together, focal adhesion turnover and FAT domains regulate the nuclear localization of paxillin, suggesting a possible role for transcriptional control, through paxillin, by focal adhesions.
Together, the IFT81 and IFT74 N-termini form the main module for intraflagellar transport of tubulin
Authors: Kubo Tomohiro , Brown Jason M. , Bellve Karl , Craige Branch , Craft Julie M. , Fogarty Kevin , Lechtreck Karl F. , Witman George B.
Published: April 2016

The assembly and maintenance of most cilia and flagella rely on intraflagellar transport (IFT). Recent in vitro studies have suggested that, together, the calponin-homology domain within the IFT81 N-terminus and the highly basic N-terminus of IFT74 form a module for IFT of tubulin. By using Chlamydomonas mutants for IFT81 and IFT74, we tested this hypothesis in vivo. Modification of the predicted tubulin-binding residues in IFT81 did not significantly affect basic anterograde IFT and length of steady-state flagella but slowed down flagellar regeneration, a phenotype similar to that seen in a strain that lacks the IFT74 N-terminus. In both mutants, the frequency of tubulin transport by IFT was greatly reduced. A double mutant that combined the modifications to IFT81 and IFT74 was able to form only very short flagella. These results indicate that, together, the IFT81 and IFT74 N-termini are crucial for flagellar assembly, and are likely to function as the main module for IFT of tubulin.
Βασιλικόν Διάταγμα περί εγκρίσεως του Καταστατικού
Authors: ΛΟΜΒΑΡΔΟΣ Κ.
Published: April 2016

no abstract
Επιστολή του Μαρκησίου της Βώθης και απάντησις της Εταιρείας.
Authors: ΧΡΙΣΤΙΑΝΙΚΗ ΑΡΧΑΙΟΛΟΓΙΚΗ ΕΤΑΙΡΕΙΑ (XAE)
Published: April 2016

no abstract

 
Γενική Συνέλευσις 2 Ιουλίου 1889
Authors: ΧΡΙΣΤΙΑΝΙΚΗ ΑΡΧΑΙΟΛΟΓΙΚΗ ΕΤΑΙΡΕΙΑ (XAE)
Published: April 2016

no abstract
Γενική Συνέλευσις 9 Ιουλίου 1889. Έκθεσις εξελεγκτικής επιτροπής
Authors: ΧΡΙΣΤΙΑΝΙΚΗ ΑΡΧΑΙΟΛΟΓΙΚΗ ΕΤΑΙΡΕΙΑ (XAE)
Published: April 2016

no abstract
Γενική Συνέλευσις 25 Ιουλίου 1889. Έγκρισις του καταστατικού της Χριστιανικής Αρχαιολογικής Εταιρείας υπό του Γεωργίου Α΄, βασιλέως των Ελλήνων.
Authors: ΧΡΙΣΤΙΑΝΙΚΗ ΑΡΧΑΙΟΛΟΓΙΚΗ ΕΤΑΙΡΕΙΑ (ΧΑΕ)
Published: April 2016

no abstract
Γενική Συνέλευσις 13ης Φεβρουαρίου 1891. Έκθεσις εξελεκτικής επιτροπής
Authors: ΧΡΙΣΤΙΑΝΙΚΗ ΑΡΧΑΙΟΛΟΓΙΚΗ ΕΤΑΙΡΕΙΑ (ΧΑΕ)
Published: April 2016

no abstract
Γενική Συνέλευσις 17ης Φεβρουαρίου 1891. Έκθεσις εξελεκτικής επιτροπής του Μουσείου
Authors: ΧΡΙΣΤΙΑΝΙΚΗ ΑΡΧΑΙΟΛΟΓΙΚΗ ΕΤΑΙΡΕΙΑ (ΧΑΕ)
Published: April 2016

no abstract
Έκθεσις του Διευθυντού του Χριστιανικού Αρχαιολογικού Μουσείου Γ. Λαμπάκη περί των κατά το έτος 1891 πεπραγμένων
Authors: ΛΑΜΠΑΚΗΣ Γεώργιος
Published: April 2016

no abstract
Ιδρυταί της Εταιρείας
Authors: ΧΡΙΣΤΙΑΝΙΚΗ ΑΡΧΑΙΟΛΟΓΙΚΗ ΕΤΑΙΡΕΙΑ (ΧΑΕ)
Published: April 2016

no abstract
Πίναξ μελών
Authors: ΧΡΙΣΤΙΑΝΙΚΗ ΑΡΧΑΙΟΛΟΓΙΚΗ ΕΤΑΙΡΕΙΑ (ΧΑΕ)
Published: April 2016

no asbtract
Αι επισκευαί του Δαφνίου
Authors: ΧΡΙΣΤΙΑΝΙΚΗ ΑΡΧΑΙΟΛΟΓΙΚΗ ΕΤΑΙΡΕΙΑ (ΧΑΕ)
Published: April 2016

no abstract
Η Παναγία των Αθηνών
Authors: ΚΑΜΠΟΥΡΟΓΛΟΥΣ Δ. Γρ.
Published: April 2016

no abstract
Ολίγαι τινές χριστιανικαί επιγραφαί
Authors: ΚΑΣΤΡΙΩΤΗΣ Π.
Published: April 2016

no abstract
Ανακοίνωσις περί της Μονής Δαφνίου
Authors: ΒΙΜΠΟΥ Σοφία
Published: April 2016

no abstract
Γενικαί Συνελεύσεις. Έκθεσις των εργασιών του Διοικητικού Συμβουλίου από 1 Ιανουαρίου 1892 - 31 Δεκεμβρίου 1892
Authors: ΧΡΙΣΤΙΑΝΙΚΗ ΑΡΧΑΙΟΛΟΓΙΚΗ ΕΤΑΙΡΕΙΑ (ΧΑΕ)
Published: April 2016

no abstract
Κατάστασις Ταμείου (1 Ιανουαρίου 1893 - 31 Δεκεμβρίου 1893). Έκθεσις εξελεγκτικής επιτροπής
Authors: ΧΡΙΣΤΙΑΝΙΚΗ ΑΡΧΑΙΟΛΟΓΙΚΗ ΕΤΑΙΡΕΙΑ (ΧΑΕ)
Published: April 2016

no abstract
Η Μονή της Οσίας Φιλοθέης (έκθεση)
Authors: ΧΡΙΣΤΙΑΝΙΚΗ ΑΡΧΑΙΟΛΟΓΙΚΗ ΕΤΑΙΡΕΙΑ (ΧΑΕ)
Published: April 2016

no abstract
Επιστολή Πατριάρχου Ιεροσολύμων Γερασίμου
Authors: ΠΑΤΡΙΑΡΧΗΣ ΙΕΡΟΣΟΛΥΜΩΝ Γεράσιμος
Published: April 2016

no abstract
A computer model simulating human glucose absorption and metabolism in health and metabolic disease states
Authors: Naftalin Richard J.
Published: April 2016

A computer model designed to simulate integrated glucose-dependent changes in splanchnic blood flow with small intestinal glucose absorption, hormonal and incretin circulation and hepatic and systemic metabolism in health and metabolic diseases e.g. non-alcoholic fatty liver disease, (NAFLD), non-alcoholic steatohepatitis, (NASH) and type 2 diabetes mellitus, (T2DM) demonstrates how when glucagon-like peptide-1, (GLP-1) is synchronously released into the splanchnic blood during intestinal glucose absorption, it stimulates superior mesenteric arterial (SMA) blood flow and by increasing passive intestinal glucose absorption, harmonizes absorption with its distribution and metabolism. GLP-1 also synergises insulin-dependent net hepatic glucose uptake (NHGU). When GLP-1 secretion is deficient post-prandial SMA blood flow is not increased and as NHGU is also reduced, hyperglycaemia follows. Portal venous glucose concentration is also raised, thereby retarding the passive component of intestinal glucose absorption.  

Increased pre-hepatic sinusoidal resistance combined with portal hypertension leading to opening of intrahepatic portosystemic collateral vessels are NASH-related mechanical defects that alter the balance between splanchnic and systemic distributions of glucose, hormones and incretins.The model reveals the latent contribution of portosystemic shunting in development of metabolic disease. This diverts splanchnic blood content away from the hepatic sinuses to the systemic circulation, particularly during the glucose absorptive phase of digestion, resulting in inappropriate increases in insulin-dependent systemic glucose metabolism.  This hastens onset of hypoglycaemia and thence hyperglucagonaemia. The model reveals that low rates of GLP-1 secretion, frequently associated with T2DM and NASH, may be also be caused by splanchnic hypoglycaemia, rather than to intrinsic loss of incretin secretory capacity. These findings may have therapeutic implications on GLP-1 agonist or glucagon antagonist usage.
short subject: Hasse Ekman at MoMA
Authors: Gustafsson Fredrik
Published: April 2016

Unlike several of his contemporaries, Swedish film-maker Hasse Ekman has never been celebrated abroad and remains relatively unknown outside his native land. As part of an effort to change that, I curated a retrospective at MoMA in New York, which took place in September 2015.
feature article: Art film in prime time: Educational programming, cultural heritage and experimental images in early Swedish television
Authors: Wahlberg Malin
Published: April 2016

Arts television has attracted scholarly attention because of its practice of re-representation, combined with an educational policy that aspired to teach ‘good taste’ to a broader audience. During the 1950s and the early 1960s, the educational and aesthetic merit of ‘art films’ was broadly recognized in Sweden, where a striking number of television programmes were dedicated to visual art. In 1956 an official state report described television as ‘to date [the] most promising tool for art propaganda’. Unlike related productions in the United Kingdom and elsewhere, the presentation of art films in Sweden also depended on a strong concern with film art. In addition to special programmes on art history and individual artists, broadcasts included experimental cinema and amateur competitions. This article accounts for the hybrid aesthetics and the intermedial and transnational appearance of the art film for public television, with special attention to those produced by the Swedish Film Unit. Here, ‘style’ is not only invoked as a matter of form and signature but also as an aesthetic ideal reflecting the educational directions and cultural doxa of early television programming. As a historical case study on media convergence, documentary form and modes of address in early public television, the example of the Swedish Film Unit illuminates a media history that upsets any simple boundary between film and television, recalling the important historical context of film art, documentary media cultures and broadcasting history.
feature article: (Not) Docking the Boat: A trademark comedy by Hasse&Tage
Authors: Ulfsdotter Boel
Published: April 2016

This article discusses the various narrative, performative and cinematic strategies of Swedish comedy team Hans Alfredson and Tage Danielsson (aka Hasse&Tage) as they moved from stage to screen through an analysis of their second film, Att angöra en brygga/Docking the Boat (Danielsson, 1965). The theoretical point of departure is the question of the relationship between classical narrative structure and plots based on a series of gags. Through a combination of formal analysis of film style and mise-en-scène in select film sequences and a general discussion of popular cultural references, gags, acting style and visual framing, the article reveals that gags in the film usually serve a narrative purpose. The sophisticated appropriation of central themes representative of New Wave aesthetics demonstrates that Docking the Boat is only partially derivative of Hasse&Tage’s ventures as stage comedians. The article concludes with a suggestion that previous experiences from a variety of media platforms had a strong impact on their ability to develop a unique and highly cinematic visual and intellectually sophisticated film style.
Levinas and the photographic undergone
Authors: Hunting John
Published: April 2016

A Levinasian approach to the photographic offers a unique opportunity to reconsider Levinas’ claim that the ‘face’ cannot be seen. Levinas’ reading of Husserl on time consciousness in mind, it is argued that vision marries an incommensurable debt and reply, a
duplicitous interface that is the very expression of embodiment and condition of the face. Brand’s and Pinchevski’s approach to the face and to photography, as incompatible yet necessary conjunctions of address and image, is recruited to advance the thesis that the duplicity belonging
to vision and to the face is made explicit when looking at photographs and films. The duplicity of the ‘photographic undergone’, both compelling vision and engineering the self-same, explains as much. Of course the photographic may or may not attest to the face – as address
and image, interruption and response, debt and reply – but even when it does the attestation is never without ambiguity and trouble, violations and doubt.
The singular photograph in durational time
Authors: Little Eileen
Published: April 2016

Freud’s formal work on mourning would indicate that in order to be successful at it you must detach from your cathexis to the loved object; yet he said to the poet Hilda Doolittle (and she writes this as an aside in a book written after her own analysis with the doctor [Tribute
to Freud]) that he remembered the last war year very well (World War I), as that year he lost his favourite daughter, Sophie, to the Spanish flu epidemic, but that, in fact, she was not lost. ‘“She is here”, he said, and he showed me a tiny locket he wore, fastened to his
watch chain’ (H.D. [1984] 2012: 128).The ‘blameless physician’ (as H.D. calls him) did not want to let go of Sophie and would have held a photograph in his hand many times every day as he checked the time, closed the locket, put it back into his pocket. This article investigates
a social media site as that contemporary ‘pocket’ in which we might place a cherished photograph, thus the tension between the durational time of the artefact and the time(s)-in-motion of the networked image.
Towards thinking in photography
Authors: Paz Anita
Published: April 2016

This article suggests itself as a movement towards a theory of thinking in photography – that is to say, of thinking photographs. The notion of art as related to thinking is by no means a contemporary one. Within this tradition that has its roots in the advent of modernity, artworks
– and particularly paintings – have long been viewed as a form of both thought and thinking. Photography’s place within this tradition, however, is not an easy one. Many of the philosophical accounts surrounding thinking in painting focus on the devices through which painting
is said to be thinking. Hubert Damisch and Gilles Deleuze offer the two most comprehensive accounts on this topic, but are the thinking devices proposed by them applicable to photography? Through the discussion of these theories, this article maps the existing philosophical landscape vis-à-vis
the thinking image: locating photographic thought within that landscape is the first step towards understanding the peculiarities of photographic thinking.
Schizophrenia: its psychological effects on family caregivers
Authors: Riley-McHugh Delvalin , Hepburn Brown Cerese , Lindo Jascinth
Published: April 2016

Purpose: Caregivers of patients diagnosed with schizophrenia experience moderate to severe caregiver burden and are at risk for developing mental disorders. This study explores the psychological effects and coping strategies of family caregivers of relatives diagnosed with schizophrenia in the developing world.

Methods: This qualitative study used the register of a community mental health clinic at a Jamaican hospital to purposively select and recruit five primary family caregivers of clients diagnosed with schizophrenia (based on the DSM IV). Consenting participants were interviewed using a semi-structured interview guide. Data were analyzed using thematic content analysis.

Results: Four of the five caregivers studied were females. Participants were either parents (4) or siblings (1) of the client diagnosed with schizophrenia and aged 42 -57years. Participants experienced feelings of anger, sadness, loss of libido, loss of appetite and depression. They expressed feelings of fear, guilt, stigma and stress related to financial responsibilities in caring for their relatives. Coping mechanisms included social support from family members and their strong faith in God.

Conclusion: Participants reported experiencing major psychological distress and ineffective coping. Community based management of individuals with schizophrenia should include strategies to support family caregivers.
No Panacea Garden
Authors: Tobias Sigmund
Published: April 2016

Essay ExcerptsThree of the seven distinguished researchers whose autobiographical chapters (Berliner, 2016; Sternberg, 2016; Sweller, 2016) I edited, and one that is in process (Gordon, in press), indicate that they were poor or indifferent students early in their academic careers. That is also true of me; so five of the first seven scholars in the Acquired Wisdom series were poor students. I did not explicitly mention my studying difficulties in this chapter because they had already been described in my memoir about how my family found safe haven from the Holocaust in Shanghai, China, during World War II (Tobias, 2009). It may be useful to examine my difficulties and how they relate to educational practice and concepts in the contemporary educational psychology literature. The late Dick Snow, a friend and colleague at Stanford, once commented that research on instructional innovations seemed to him like a random walk through the panacea garden. I have become sceptical of any instructional development, theory, or instructional method that is expected to improve learning for all students in all subjects. I have lived through prior panaceas like programmed and computer assisted instruction, multimedia education, computer games, and educational movements such as progressive, competency based, open corridor, and inquiry education, and the current panacea - constructivist instruction - from all of which I learned something. There are no panaceas that will easily improve learning for everyone, because good instruction is hard work and difficult to do. [Download the PDF ]
k-nearest neighbors on road networks
Authors: Abeywickrama Tenindra , Cheema Muhammad Aamir , Taniar David
Published: April 2016

A
k
nearest neighbor (
k
NN) query on road networks retrieves the
k
closest points of interest (POIs) by their network distances from a given location. Today, in the era of ubiquitous mobile computing, this is a highly pertinent query. While Euclidean distance has been used as a heuristic to search for the closest POIs by their road network distance, its efficacy has not been thoroughly investigated. The most recent methods have shown significant improvement in query performance. Earlier studies, which proposed disk-based indexes, were compared to the current state-of-the-art in main memory. However, recent studies have shown that main memory comparisons can be challenging and require careful adaptation. This paper presents an extensive experimental investigation in main memory to settle these and several other issues. We use efficient and fair memory-resident implementations of each method to reproduce past experiments and conduct additional comparisons for several overlooked evaluations. Notably we revisit a previously discarded technique (IER) showing that, through a simple improvement, it is often the best performing technique.
Discovering the skyline of web databases
Authors: Asudeh Abolfazl , Thirumuruganathan Saravanan , Zhang Nan , Das Gautam
Published: April 2016

Many web databases are "hidden" behind proprietary search interfaces that enforce the top-
k
output constraint, i.e., each query returns at most
k
of all matching tuples, preferentially selected and returned according to a proprietary ranking function. In this paper, we initiate research into the novel problem of skyline discovery over top-
k
hidden web databases. Since skyline tuples provide critical insights into the database and include the top-ranked tuple for every possible ranking function following the monotonic order of attribute values, skyline discovery from a hidden web database can enable a wide variety of innovative third-party applications over one or multiple web databases. Our research in the paper shows that the critical factor affecting the cost of skyline discovery is the type of search interface controls provided by the website. As such, we develop efficient algorithms for three most popular types, i.e., one-ended range, free range and point predicates, and then combine them to support web databases that feature a mixture of these types. Rigorous theoretical analysis and extensive real-world online and offline experiments demonstrate the effectiveness of our proposed techniques and their superiority over baseline solutions.
Summer water temperature of lowland Mazovian rivers in the context of fisheries management
Authors: Łaszewski Maksym
Published: April 2016

Water temperatures in three upstream and three downstream profiles of the Jeziorka, Świder, and Utrata rivers were recorded in the summer period of hydrological year 2015 using digital data loggers. The measurement data was used to estimate statistical and ecological thermal parameters. The results demonstrated that water temperature in the studied lowland rivers was quite similar, except in the downstream reaches of the Utrata River, which is subjected to strong anthropogenic modification. The best thermal conditions for the survival and growth of the cold-water fish assemblage were observed upstream in the Jeziorka River in Głuchów, while the worst were downstream in the Utrata River in Nowy Łuszczewek. However, the results suggest that in quasi-natural rivers, such as the Jeziorka and Świder, cold-water fish can exist and be stocked in both the upstream and downstream segments. For the warm-water fish assemblage, the best thermal conditions were noted downstream in the Utrata River, while the worst were upstream in the Świder River; nevertheless, differences between the rivers were relatively small. The results of the analysis have practical implications for managing these waters with a view to optimizing angling and natural resources.
Protective efficiency of an inactivated vaccine against Streptococcus iniae in olive flounder, Paralichthys olivaceus
Authors: Jeong Yong-Uk , Subramanian Dharaneedharan , Yeoung-Hwan Jang , Kim Dong-Hwi , Park So-Hyun , Park Kyung-il , Lee Young-Don , Heo Moon-Soo
Published: April 2016

Streptococcus iniae is a causative agent of hemorrhagic septicemia in olive flounder, Paralichthys olivaceus, in Korea, resulting in serious economic losses. As a preventive measure, M VAC INIAE (Mastuken, Japan) was prepared from the S. iniae F2K strain and tested against the SI-36 strain prevalent on flounder fish farms on Jeju Island, Korea. F2K had a serotype of 38 (−) and SI-36 38 (+). The vaccine recognized both serotypes. It showed a very high effective immune response against S. iniae; the challenge test using the S. iniae SI-36 strain resulted in a relative percent survival (RPS) of 85.7-87.0% 2 weeks after vaccination and 71.0-80.0% 6 months after vaccination. Field vaccination and clinical challenge tests were performed at local Jeju aquafarms with S. iniae SI-36. These showed significantly reduced cumulative mortality when compared to the control group with RPS rates that ranged between 71-80%. Hence, the present study suggests that this vaccine showed a significant immune response against S. iniae and could be applied in commercial aquafarms as a therapeutic agent against β-hemolytic streptococcosis in cultured P. olivaceus.
Growth performance and feed utilization of keureling (Tor tambra) fingerlings fed a formulated diet with different doses of vitamin E (alpha-tocopherol)
Authors: Muchlisin Zainal A. , Arisa Ayu A. , Muhammadar Abdullah A. , Fadli Nur , Arisa Iko I. , Siti-Azizah Mohd N.
Published: April 2016

The objective of the present study was to determine the optimum dosage of vitamin E (alpha-tocopherol) in the diet of keureling, Tor tambra (Val.) fingerlings for optimal growth performance and feed utilization. Five doses of vitamin E were tested: 0 mg kg−1 feed (control); 150 mg kg−1 feed; 300 mg kg−1 feed; 450 mg kg−1 feed; 600 mg kg−1. The feed ratio was 5% body weight, which was delivered twice daily at 08:00 and 17:00 for 60 days. The results showed that higher growth performance, feeding conversion ratios, feed efficiency, protein retention, and protein digestibility were obtained at 600 mg kg−1 feed, but the value was not significantly different from the other doses. The optimal dose in terms of the hepatosomatic index and survival rate was 300 mg kg−1. Hence, it was concluded that the optimum, most economical dose of vitamin E supplement for keureling (T. tambra) was 150 mg kg−1 feed, because this value was not significantly different from the doses of 300 and 600 mg kg−1 feed.
Stoic Utopia: The Use of Friendship in Creating the Ideal Society
Authors: Weiss Robin
Published: April 2016

The members of the Stoics’ ideal society are bound together by friendship. The structure of this harmonious society and the manner in which it is able to remain harmonious can therefore be inferred from the nature of the friendships its members maintain with one another. It can be argued that the Stoics give content to the virtues of friendship reportedly possessed by members of the ideal society, explaining in what these virtues consist, then indicating how those who possess them trend to form the kinds of relationships, i.e. friendships, of which the social fabric is ideally woven. The person who possesses these virtues (i.) refrains from harming others, and (ii.) extends goodwill to other people where it does not conflict with prior obligations. The Stoics thus describe the manner in which virtuous peoble are able to befriend, and maintain friendly relations with other people by practicing the virtues of friendship. Thus, the number of mutually beneficial relationships is multiplied as virtuous people extend friendship to as many people as are capable of returning it. As a result, the ability of virtuous people to bring about the ideal society is limited only by the unwillingness of others to return their gestures of friendship.