bluuebunny/crossref_metadata_2025 huggingface dataset:
Translation and validation of the medication management patient satisfaction survey: The Lebanese Arabic version
Authors: Alaa Eddine Nada , Schreiber James B. , Amin Mohamed Ezzat Khamis
Published: February 2023

Background: No Arabic translation exists for the medication management patient satisfaction survey (MMPSS), a 10-item psychometrically valid patient satisfaction survey tool developed to assess patient satisfaction for comprehensive medication management. The objective of this study is to translate the medication management patient satisfaction survey into Lebanese Arabic while culturally adapting and assessing the psychometric properties of the translated survey in the outpatient setting.

Methods: Guidelines for translation, adaptation, and validation of instruments for cross-cultural healthcare research were followed. The process included forward translation, expert panel review, back-translation, pretesting, and cognitive interviewing. Participants were approached after picking up their medications from the pharmacy at a primary care facility. The medication management patient satisfaction survey was administered verbally by two trained data collectors. Instrument psychometric analyses included testing both for reliability using Cronbach’s alpha (α) and McDonald’s omega (ω) and for construct validity using exploratory factor analysis (EFA). Pearson correlations between items were calculated.

Results: During the translation process, the term “clinical pharmacist” was changed to “pharmacist today” for improved understanding. Four items were adapted through minor linguistic modifications. Data were collected from 143 patients. The mean age of participants was 72 years. Participants were mostly females (69%) and had an average of four comorbidities and eight daily medications. Findings from Cronbach’s α and McDonald’s ω indicated that the internal consistency among items from one to nine was very strong (α = 0.90; ω = 0.90). Exploratory factor analysis indicated that all items are strongly influenced by one factor, except for item six, “My clinical pharmacist is working as a team member with my other healthcare providers” which was the least influenced (loading = 0.44) with the highest uniqueness (0.81). The latent factor captured over 50% of the variance originally observed between variables. Items four and five “My clinical pharmacist helped me find easier ways to take my medicines” and “My clinical pharmacist helped me understand the best ways to take my medicines”, had the strongest correlation (0.77), while the weakest correlation was seen between item six “My clinical pharmacist is working as a team member with my other healthcare providers” and other items.

Conclusion: The Lebanese Arabic version of the medication management patient satisfaction survey was produced as a brief tool to serve as a valid and reliable instrument for measuring patient satisfaction with comprehensive medication management services.
Kinetic model of resonant nanoantennas in polymer for laser induced fusion
Authors: Papp István , Bravina Larissa , Csete Mária , Kumari Archana , Mishustin Igor N. , Motornenko Anton , Rácz Péter , Satarov Leonid M. , Stöcker Horst , Strottman Daniel D. , Szenes András , Vass Dávid , Szokol Ágnes Nagyné , Kámán Judit , Bonyár Attila , Biró Tamás S. , Csernai László P. , Kroó Norbert
Published: February 2023

Studies of resilience of light-resonant nanoantennas in vacuum are extended to consider the case of polymer embedding. This modifies the nanoantenna’s lifetime and resonant laser pulse energy absorption. The effective resonance wavelength is shortened, the peak momentum of resonantly oscillating electrons in the nanorod is reduced by one-third, while the available lifespan of the resonance condition remains the same. This response is expected to strengthen the laser pulse induced nuclear fusion processes. Related numerical simulations were performed using particle-in-cell method in a simulation box of the size 0.223 μm3, treating the conduction electrons as strongly coupled plasma. In the modeling the polymer background was added with the experimentally measured refractive index of 1.53.
Unstable SpO2 in preterm infants: The key role of reduced ventilation to perfusion ratio
Authors: Stoecklin Benjamin , Choi Y. Jane , Dassios Theodore , Jones J. Gareth , Lockwood Geoffrey G. , Pillow J. Jane
Published: February 2023

Introduction: Instability of peripheral oxyhemoglobin saturation (SpO2) in preterm infants is correlated with late disability and is poorly understood. We hypothesised that a reduced ventilation to perfusion ratio (VA/Q) is the key predisposing factor for SpO2 instability.

Methods: We first used a mathematical model to compare the effects of reduced VA/Q or shunt on SaO2 stability (SaO2 and SpO2 are used for model and clinical studies respectively). Stability was inferred from the slope of the SaO2 vs. inspired oxygen pressure (PIO2) curve as it intersects the 21 kPa PIO2 line (breathing air). Then, in a tertiary neonatal intensive care unit, paired hourly readings of SpO2 and PIO2 were recorded over a 24 h period in week old extremely preterm infants. We noted SpO2 variability and used an algorithm to derive VA/Q and shunt from the paired SpO2 and PIO2 measurements.

Results: Our model predicted that when VA/Q < 0.4, a 1% change in PIO2 results in >8% fluctuation in SaO2 at 21 kPa PIO2. In contrast, when a 20% intrapulmonary shunt was included in the model, a 1% change in PIO2 results in <1% fluctuation in the SaO2. Moreover, further reducing the VA/Q from 0.4 to 0.3 at 21 kPa PIO2 resulted in a 24% fall in SaO2. All 31 preterm infants [mean gestation (±standard deviation) 26.2 (±1) week] had VA/Q < 0.74 (normal >0.85) but only two infants had increased shunt at 1.1 (±0.5) weeks’ postnatal age. Median (IQR) SpO2 fluctuation was 8 (7)%. The greatest SpO2 fluctuations were seen in infants with VA/Q < 0.52 (n = 10): SpO2 fluctuations ranged from 11%–17% at a constant PIO2 when VA/Q < 0.52. Two infants had reduced VA/Q and increased shunt (21% and 27%) which resolved into low VA/Q after 3–6 h.

Discussion: Routine monitoring of PIO2 and SpO2 can be used to derive a hitherto elusive measure of VA/Q. Predisposition to SpO2 instability results from reduced VA/Q rather than increased intrapulmonary shunt in preterm infants with cardiorespiratory disease. SpO2 instability can be prevented by a small increase in PIO2.
Global trends and research frontiers on heat stress in poultry from 2000 to 2021: A bibliometric analysis
Authors: Uyanga Victoria Anthony , Musa Taha H. , Oke Oyegunle Emmanuel , Zhao Jingpeng , Wang Xiaojuan , Jiao Hongchao , Onagbesan Okanlawon M. , Lin Hai
Published: February 2023

Background: Heat stress remains a major environmental factor affecting poultry production. With growing concerns surrounding climate change and its antecedent of global warming, research on heat stress in poultry has gradually gained increased attention. Therefore, this study aimed to examine the current status, identify the research frontiers, and highlight the research trends on heat stress in poultry research using bibliometric analysis.

Methods: The literature search was performed on the Web of Science Core Collection database for documents published from 2000 to 2021. The documents retrieved were analyzed for their publication counts, countries, institutions, keywords, sources, funding, and citation records using the bibliometric app on R software. Network analysis for co-authorship, co-occurrence, citation, co-citation, and bibliographic coupling was visualized using the VOSviewer software.

Results: A total of 468 publications were retrieved, and over the past two decades, there was a gradual increase in the annual number of publications (average growth rate: 4.56%). China had the highest contribution with respect to the number of publications, top contributing authors, collaborations, funding agencies, and institutions. Nanjing Agricultural University, China was the most prolific institution. Kazim Sahin from Firat University, Turkey contributed the highest number of publications and citations to heat stress in poultry research, and Poultry Science was the most productive and the most cited journal. The top 10 globally cited documents mainly focused on the effects of heat stress, alleviation of heat stress, and the association between heat stress and oxidative stress in poultry. All keywords were grouped into six clusters which included studies on “growth performance”, “intestinal morphology”, “heat stress”, “immune response”, “meat quality”, and “oxidative stress” as current research hotspots. In addition, topics such as; “antioxidants”, “microflora”, “intestinal barrier”, “rna-seq”, “animal welfare”, “gene expression”, “probiotics”, “feed restriction”, and “inflammatory pathways” were identified for future research attention.

Conclusion: This bibliometric study provides a detailed and comprehensive analysis of the global research trends on heat stress in poultry over the last two decades, and it is expected to serve as a useful reference for potential research that will help address the impacts of heat stress on poultry production globally.
Embryonic ethanol exposure disrupts craniofacial neuromuscular integration in zebrafish larvae
Authors: Ghosal Ritika , Borrego-Soto Gissela , Eberhart Johann K.
Published: February 2023

Forming a vertebrate head involves the meticulous integration of multiple tissue types during development. Prenatal alcohol exposure is known to cause a variety of birth defects, especially to tissues in the vertebrate head. However, a systematic analysis of coordinated defects across tissues in the head is lacking. Here, we delineate the effects of ethanol on individual tissue types and their integration during craniofacial development. We found that exposure to 1% ethanol induced ectopic cranial muscle and nerve defects with only slight effects on skeletal pattern. Ectopic muscles were, however, unaccompanied by ectopic tendons and could be partially rescued by anesthetizing the larvae before muscle fibers appeared. This finding suggests that the ectopic muscles result from fiber detachment and are not due to an underlying muscle patterning defect. Interestingly, immobilization did not rescue the nerve defects, thus ethanol has an independent effect on each tissue even though they are linked in developmental time and space. Time-course experiments demonstrated an increase in nerve defects with ethanol exposure between 48hpf-4dpf. Time-lapse imaging confirmed the absence of nerve pathfinding or misrouting defects until 48hpf. These results indicate that ethanol-induced nerve defects occur at the time of muscle innervation and after musculoskeletal patterning. Further, we investigated the effect of ethanol on the neuromuscular junctions of the craniofacial muscles and found a reduced number of postsynaptic receptors with no significant effect on the presynaptic terminals. Our study shows that craniofacial soft tissues are particularly susceptible to ethanol-induced damage and that these defects appear independent from one another. Thus, the effects of ethanol on the vertebrate head appear highly pleiotropic.
Response of photomorphogenesis and photosynthetic properties of sweet pepper seedlings exposed to mixed red and blue light
Authors: Li Yan , Xin Guofeng , Shi Qinghua , Yang Fengjuan , Wei Min
Published: February 2023

Various light spectra, especially red (RL) and blue light (BL), have great effects on physiological processes and growth of plants. Previously, we revealed that the plant photomorphogenesis and photosynthesis of sweet pepper was significantly altered under BL or mixed RL and BL. The present study aimed to elucidate how mixed RL and BL influences plant photosynthesis during photomorphogenesis. We examined the growth, plant morphology, photosynthetic response of sweet pepper seedlings under monochromatic RL, BL, different ratios of mixed RL and BL (9R1B, 6R1B, 3R1B, 1R1B, 1R3B) with the same photosynthetic photon flux density of 300 μmol·m-2·s-1. White light (WL) were used as a control. The findings showed that the elongation of hypocotyl and first internode as well as leaf expansion were all stimulated by RL, while significantly restrained by BL compared with WL. Conversely, the leaf development, biomass accumulation and photosynthetic properties were inhibited by RL but promoted by BL. Additionally, compared with WL and other treatments, 3R1B could significantly improve the net photosynthetic rate, gas exchange, photosynthetic electron transport capacity, photochemical efficiency, shoot and root biomass accumulation. Furthermore, seedlings grew robustly and exhibited the greatest value of seedling index when exposed to this treatment. Overall, these results suggested that pepper seedlings grown under 3R1B performed better, possibly due to the more balanced light spectrum. It was more conducive to improve the plant photomorphogenesis and photosynthesis of sweet pepper, and a higher biomass accumulation and energy utilization efficiency could be achieved simultaneously under this mixed light spectrum.
Oxygenic photosynthetic responses of cyanobacteria exposed under an M-dwarf starlight simulator: Implications for exoplanet’s habitability
Authors: Battistuzzi Mariano , Cocola Lorenzo , Claudi Riccardo , Pozzer Anna Caterina , Segalla Anna , Simionato Diana , Morosinotto Tomas , Poletto Luca , La Rocca Nicoletta
Published: February 2023

Introduction

The search for life on distant exoplanets is expected to rely on atmospheric biosignatures detection, such as oxygen of biological origin. However, it is not demonstrated how much oxygenic photosynthesis, which on Earth depends on visible light, could work under spectral conditions simulating exoplanets orbiting the Habitable Zone of M-dwarf stars, which have low light emission in the visible and high light emission in the far-red/near-infrared. By utilizing cyanobacteria, the first organisms to evolve oxygenic photosynthesis on our planet, and a starlight simulator capable of accurately reproducing the emission spectrum of an M-dwarf in the range 350–900 nm, we could answer this question.

Methods

We performed experiments with the cyanobacterium Chlorogloeopsis fritschii PCC6912, capable of Far-Red Light Photoacclimation (FaRLiP), which allows the strain to harvest far-red in addition to visible light for photosynthesis, and Synechocystis sp. PCC6803, a species unable to perform this photoacclimation, comparing their responses when exposed to three simulated light spectra: M-dwarf, solar and far-red. We analysed growth and photosynthetic acclimation features in terms of pigment composition and photosystems organization. Finally, we determined the oxygen production of the strains directly exposed to the different spectra.

Results

Both cyanobacteria were shown to grow and photosynthesize similarly under M-dwarf and solar light conditions: Synechocystis sp. by utilizing the few photons in the visible, C. fritschii by harvesting both visible and far-red light, activating the FaRLiP response.

Discussion

Our results experimentally show that an M-dwarf light spectrum could support a biological oxygen production similar to that in solar light at the tested light intensities, suggesting the possibility to discover such atmospheric biosignatures on those exoplanets if other boundary conditions are met.
Diproline-induced resistance to parasitic nematodes in the same and subsequent rice generations: Roles of iron, nitric oxide and ethylene
Authors: De Kesel Jonas , Bonneure Eli , Frei Michael , De Meyer Tim , Mangelinckx Sven , Kyndt Tina
Published: February 2023

Induced resistance (IR) is a plant phenotype characterized by lower susceptibility to biotic challenges upon elicitation by so-called IR stimuli. Earlier, we identified diproline (cyclo(l-Pro-l-Pro)) as IR stimulus that protects rice (Oryza sativa) against the root-knot nematode Meloidogyne graminicola (Mg). In the current study, detailed transcriptome analyses at different time points, and under uninfected and nematode-infected conditions revealed that this rice IR phenotype is correlated with induction of genes related to iron (Fe), ethylene (ET) and reactive oxygen species (ROS)/reactive nitrogen species (RNS) metabolism. An infection experiment under Fe limiting conditions confirmed that diproline-IR is only effective under optimal Fe supply. Although total root Fe levels were not affected in diproline-treated plants, phytosiderophore secretion was found to be induced by this treatment. Experiments on mutant and transgenic rice lines impaired in ET or ROS/RNS metabolism confirmed that these metabolites are involved in diproline-IR. Finally, we provide evidence for transgenerational inheritance of diproline-IR (diproline-TIR), as two successive generations of diproline-treated ancestors exhibited an IR phenotype while themselves never being exposed to diproline. Transcriptome analyses on the offspring plants revealed extensive overlap between the pathways underpinning diproline-IR and diproline-TIR. Although diproline induces significant systemic changes in global DNA methylation levels early after treatment, such changes in DNA methylation were not detected in the descendants of these plants. To our knowledge, this is the first report of TIR in rice and the first transcriptional assessment of TIR in monocots.
The role of nitric oxide and hydrogen sulfide in regulation of redox homeostasis at extreme temperatures in plants
Authors: Kolupaev Yuriy E. , Yemets Alla I. , Yastreb Tetiana O. , Blume Yaroslav B.
Published: February 2023

Nitric oxide and hydrogen sulfide, as important signaling molecules (gasotransmitters), are involved in many functions of plant organism, including adaptation to stress factors of various natures. As redox-active molecules, NO and H2S are involved in redox regulation of functional activity of many proteins. They are also involved in maintaining cell redox homeostasis due to their ability to interact directly and indirectly (functionally) with ROS, thiols, and other molecules. The review considers the involvement of nitric oxide and hydrogen sulfide in plant responses to low and high temperatures. Particular attention is paid to the role of gasotransmitters interaction with other signaling mediators (in particular, with Ca2+ ions and ROS) in the formation of adaptive responses to extreme temperatures. Pathways of stress-induced enhancement of NO and H2S synthesis in plants are considered. Mechanisms of the NO and H2S effect on the activity of some proteins of the signaling system, as well as on the state of antioxidant and osmoprotective systems during adaptation to stress temperatures, were analyzed. Possibilities of practical use of nitric oxide and hydrogen sulfide donors as inductors of plant adaptive responses are discussed.
The Teaching Strategy of Socio-Political Education by Deep Learning Under Educational Psychology
Authors: Chen Zhen , Wen Lan , He Xiaoqing , Chen Peiyao , Wu Hua
Published: February 2023

This study aims to optimize the teaching content of ideological and political courses and guide students to establish correct values. Inspired by Artificial Intelligence, the K-means clustering algorithm was applied to the neural collaborative filtering algorithm through temporal data. Besides, a deep learning algorithm was designed for the improved matrix factorization. The evaluation indicators were selected through experiments. The relevant data sets were used for simulation and testing. The test results indicated that the Root Mean Square Error of this scheme was 1.251, and the Mean Absolute Error was 0.625. These index measurement values were better than those of similar algorithms, indicating this model has better performance after optimization and can recommend suitable courses. The innovative algorithm designed to construct the classroom teaching model of social and political education can accurately recommend proper courses according to the students’ learning situation reflecting their psychological states. The research provides adaptive teaching for students, enables interaction between teachers and students, and helps students form correct values. It also has an important role in improving the teaching strategies.
Families with young children during the COVID-19 pandemic—The importance of family type, perceived partnership roles, parental stress, and social support for changes in the home learning environment during lockdown
Authors: Prokupek Luisa , Cohen Franziska , Oppermann Elisa , Anders Yvonne
Published: February 2023

Beginning in March 2020, the lockdown precipitated by the COVID-19 pandemic resulted in many challenges, especially for families with young children. Many children had little or no access to institutional education. Therefore, they were even more dependent on their parents providing them with home learning activities (HLA) to support their development. We examined the adaptability of families with regard to changes in parents’ provision of HLA in traditional two-parent families, single parent families, and large families compared to before the lockdown. We focused on family resources, such as a supportive distribution of roles within the partnership, or social support, as predicting factors of adaptability in N = 8,513 families with children aged 18–69 months. In addition, we considered parental stress as a further influencing factor. The cross-sectional data depicts families from a nationwide online survey, which we conducted during spring 2020 in Germany. We found that (a) all three family types offered their children more learning activities at home, albeit with slight differences between the families. However, (b) we identified differences in the factors influencing families’ adaptability: Across all family types, we found slight to medium negative relations between adaptability and parental stress. The relations were most evident in large families. Furthermore, social support exhibits somewhat positive relations to the adaptability of large families. For adaptability in single-parent families, gender differences were initially evident. Among single fathers, the change in parental HLA was stronger than among single mothers. However, this relation disappeared when we took parental stress and social support into account. For traditional two-parent families and single parents, our analyses revealed (c) barely significant relations between the investigated predictors and changes in HLA during lockdown. Overall, our study confirms that high stress limits the adaptability of providing HLA in families and that social support mitigates negative relations between stress and the provision of HLA, especially in large families. In order to develop effective and needs-based family support programs, it is therefore important to help parents cope with stress and provide them with low-threshold social support. The extent to which these services need to be adapted to different family types must be surveyed in more depth.
Contextual considerations for deception production and detection in forensic interviews
Authors: Markowitz David M. , Hancock Jeffrey T. , Woodworth Michael T. , Ely Maxwell
Published: February 2023

Most deception scholars agree that deception production and deception detection effects often display mixed results across settings. For example, some liars use more emotion than truth-tellers when discussing fake opinions on abortion, but not when communicating fake distress. Similarly, verbal and nonverbal cues are often inconsistent predictors to assist in deception detection, leading to mixed accuracies and detection rates. Why are lie production and detection effects typically inconsistent? In this piece, we argue that aspects of the context are often unconsidered in how lies are produced and detected. Greater theory-building related to contextual constraints of deception are therefore required. We reintroduce and extend the Contextual Organization of Language and Deception (COLD) model, a framework that outlines how psychological dynamics, pragmatic goals, and genre conventions are aspects of the context that moderate the relationship between deception and communication behavior such as language. We extend this foundation by proposing three additional aspects of the context — individual differences, situational opportunities for deception, and interpersonal characteristics — for the COLD model that can specifically inform and potentially improve forensic interviewing. We conclude with a forward-looking perspective for deception researchers and practitioners related to the need for more theoretical explication of deception and its detection related to the context.
Trends in mortality and causes of death among Chinese adolescents aged 10–19 years from 1990 to 2019
Authors: Zhu Jiaxin , Li Yilu , Zhang Chengcheng , He Jun , Niu Lu
Published: February 2023

Objective

Promoting adolescent health is essential to achieving the goals of the Healthy China 2030 (HC 2030) initiative. As socioeconomic conditions improve and medical practices and disease patterns evolve, adolescent mortality rates and causes of death vary considerably. This study provides up-to-date data on adolescent mortality and causes of death in China, highlighting key areas of focus for investment in adolescent health.

Methods

Data regarding mortality and causes of death in Chinese adolescents aged 10–19 years were extracted from the Global Burden of Disease study from 1990 to 2019. The data variables were examined according to year, sex, and age. The autoregressive integrated moving average model was used to predict non-communicable disease (NCD) mortality rates and rank changes in the leading causes of death until 2030.

Results

The all-cause mortality rate (per 100,000 population) of Chinese adolescents aged 10–19 years steadily declined from 1990 (72.6/100,000) to 2019 (28.8). Male adolescents had a higher mortality (37.5/100,000 vs. 18.6 in 2019) and a slower decline rate (percent: −58.7 vs. −65.0) than female adolescents. Regarding age, compared with those aged 10–14 years, the mortality rate of adolescents aged 15–19 years had a higher mortality (35.9/100,000 vs. 21.2 in 2019) and a slower decrease rate (percent: −57.6 vs. −63.2). From 1990 to 2019, the rates of communicable, maternal, and nutritional diseases declined the most (percent: −80.0), while injury and NCDs mortality rates were relatively slow (percent: −50.0 and −60.0). In 2019, the five leading causes of death were road injuries (6.1/100,000), drowning (4.5), self-harm (1.9), leukemia (1.9), and congenital birth defects (1.3). Furthermore, NCDs' mortality rate decreased by −46.6% and −45.4% between 2015–2030 and 2016–2030, respectively.

Conclusion

A notable decline was observed in all-cause mortality rates among Chinese adolescents aged 10–19 years. In addition, the mortality rates of NCDs are projected to meet the target from the Global Strategy for Women's, Children's, and Adolescents' Health (2016–2030) and HC2030 reduction indicators by 2030. However, it should be noted that injury is the leading cause of death, with sexual and age disparities remaining consistent.
Widespread clinical implementation of the teen online problem-solving program: Progress, barriers, and lessons learned
Authors: Wade Shari L. , Walsh Kathleen , Slomine Beth S. , Davis Kimberly C. , Heard Cherish , Maggard Brianna , Sutcliffe Melissa , Van Tubbergen Marie , McNally Kelly , Deidrick Kathleen , Kirkwood Michael W. , Lantagne Ann , Ashman Sharon , Scratch Shannon , Chesley Gayle , Johnson-Kerner Bethany , Johnson Abigail , Cirincione Lindsay , Austin Cynthia
Published: February 2023

Objective

We describe the clinical implementation in North America of Teen Online Problem Solving (TOPS), a 10+ session, evidence-based telehealth intervention providing training in problem-solving, emotion regulation, and communication skills.

Methods

Twelve children's hospitals and three rehabilitation hospitals participated, agreeing to train a minimum of five therapists to deliver the program and to enroll two patients with traumatic brain injuries (TBI) per month. Barriers to reach and adoption were addressed during monthly calls, resulting in expansion of the program to other neurological conditions and extending training to speech therapists.

Results

Over 26 months, 381 patients were enrolled (199 TBI, 182 other brain conditions), and 101 completed the program. A total of 307 therapists were trained, and 58 went on to deliver the program. Institutional, provider, and patient barriers and strategies to address them are discussed.

Conclusions

The TOPS implementation process highlights the challenges of implementing complex pediatric neurorehabilitation programs while underscoring potential avenues for improving reach and adoption.
Retelling social inequalities in the era of market competition: Review and discussion for sustainable welfare development
Authors: Pechdin Watchara , Sarnkhaowkhom Chawapon , Kanthanetr Sudarat , Willemse Martin Pieter
Published: February 2023

As the prevalence of social inequalities has become increasingly evident, the implementation of social welfare policies in countries across the globe has faced considerable obstacles and has not yielded the desired results. In spite of the fact that social welfare policies are formulated to reduce inequalities in society, the recent increase in inequalities has raised questions about whether or not welfare implementation is appropriate to the social context where resource distributions are dominated by economic structure. Inspired by this, the aim of this paper is to echo contemporary perspectives on social inequality and challenges that have contributed to its development under the economic system of market competition. The contemporary matters arising from social inequalities, which include intergenerational inequality, gender-based inequality, health inequality, and education inequality, are examined in accordance with the context of market competition. This would hopefully enable academicians to timely recognize and address ideological and paradoxical social inequalities and welfare development within their society.
Machine learning in the prediction of cardiac surgery associated acute kidney injury with early postoperative biomarkers
Authors: Fan Rui , Qin Wei , Zhang Hao , Guan Lichun , Wang Wuwei , Li Jian , Chen Wen , Huang Fuhua , Zhang Hang , Chen Xin
Published: February 2023

Purpose

To establish novel prediction models for predicting acute kidney injury (AKI) after cardiac surgery based on early postoperative biomarkers.

Patients and methods

This study enrolled patients who underwent cardiac surgery in a Chinese tertiary cardiac center and consisted of a discovery cohort (n = 452, from November 2018 to June 2019) and a validation cohort (n = 326, from December 2019 to May 2020). 43 biomarkers were screened using the least absolute shrinkage and selection operator and logistic regression to construct a nomogram model. Three tree-based machine learning models were also established: eXtreme Gradient Boosting (XGBoost), random forest (RF) and deep forest (DF). Model performance was accessed using area under the receiver operating characteristic curve (AUC). AKI was defined according to the Kidney Disease Improving Global Outcomes criteria.

Results

Five biomarkers were identified as independent predictors of AKI and were included in the nomogram: soluble ST2 (sST2), N terminal pro-brain natriuretic peptide (NT-proBNP), heart-type fatty acid binding protein (H-FABP), lactic dehydrogenase (LDH), and uric acid (UA). In the validation cohort, the nomogram achieved good discrimination, with AUC of 0.834. The machine learning models also exhibited adequate discrimination, with AUC of 0.856, 0.850, and 0.836 for DF, RF, and XGBoost, respectively. Both nomogram and machine learning models had well calibrated. The AUC of sST2, NT-proBNP, H-FABP, LDH, and UA to discriminate AKI were 0.670, 0.713, 0.725, 0.704, and 0.749, respectively. In addition, all of these biomarkers were significantly correlated with AKI after adjusting clinical confounders (odds ratio and 95% confidence interval of the third vs. the first tertile: sST2, 3.55 [2.34–5.49], NT-proBNP, 5.50 [3.54–8.71], H-FABP, 6.64 [4.11–11.06], LDH, 7.47 [4.54–12.64], and UA, 8.93 [5.46–15.06]).

Conclusion

Our study provides a series of novel predictive models and five biomarkers for enhancing the risk stratification of AKI after cardiac surgery.
A systematic approach toward progressive improvement of national antimicrobial resistance surveillance systems in food and agriculture sectors
Authors: Keck Nicolas , Treilles Michaël , Gordoncillo Mary , Ivette Ouoba Labia Irène , Dauphin Gwenaëlle , Dorado-Garcia Alejandro , Eckford Suzanne , Kabali Emmanuel , Gourlaouen Morgane , Latronico Francesca , Lubroth Juan , Sumption Keith , Song Junxia , Mouillé Béatrice
Published: February 2023

The first Food and Agriculture Organization of the United Nations (FAO) Action Plan on antimicrobial resistance (AMR), published in 2016, identified the need to develop capacity for AMR surveillance and monitoring in food and agriculture sectors. As part of this effort, FAO has developed the “Assessment Tool for Laboratories and AMR Surveillance Systems” (FAO-ATLASS) to assist countries in systematically assessing their AMR surveillance system in food and agriculture. FAO-ATLASS includes two different modules for surveillance and laboratory assessment. Each module includes two questionnaires that collect either qualitative or semi-quantitative data to describe and score the performance of national AMR surveillance system data production network, data collection and analysis, governance, communication and overall sustainability in a standardized manner. Based on information captured in the questionnaire by trained assessors (1) tables and figures describing the outputs of the surveillance system are automatically generated (2) a Progressive Improvement Pathway (PIP) stage, ranging from “1-limited” to “5-sustainable”, is assigned to each laboratory assessed in the country, each area of the surveillance system and also to the overarching national AMR surveillance system. FAO-ATLASS allows national authorities to implement a strategic stepwise approach to improving their AMR surveillance systems via the FAO-ATLASS PIP system and provides an evidence base for actions and advocacy. The implementation of FAO-ATLASS at regional and global levels can contribute to harmonize and better coordinate strategies aimed at implementing an integrated AMR surveillance system under the One Health approach.
Identification and analysis of differentially expressed (DE) circRNA in epididymis of yak and cattleyak
Authors: Li Chunhai , Yan Yan , Pan Cheng , Adjei Michael , Shahzad Khuram , Wang Peng , Pan Meilan , Li Kerui , Wang Ye , Zhao Wangsheng
Published: February 2023

Circular RNAs (circRNAs), as endogenous non-coding RNA with unique closed ring structure, is closely related to animal reproduction, and understanding the expression of circRNA in yak and cattleyak epididymal tissues is of great significance for understanding cattleyak sterility. Based on this, we screened and identified the differentially expressed circRNA in the epididymis of three yaks and two cattleyak. A total of 1,298 circRNAs were identified in the epididymis of yak and cattleyak, of which 137 differentially expressed (DE) circRNAs and the functions of some of them were elucidated in this research, as well as qPCR verification to 6 circRNAs from the 137 DE circRNAs. Gene Ontology (GO) enrichment analysis suggested that DE circRNAs were mainly related to metabolic process, development process, immune system process, reproductive process, reproduction, biological adhesion and growth. COG classification analysis showed that the DE circRNAs derived genes were mainly related to replication, recombination and repair. KEGG pathway analysis suggested that DE circRNAs were mainly involved in RNA degradation. In addition, we also screened Bta-mir-103, which is a circRNA binding miRNA related to sperm activity.
Dietary utilization of mealworm frass in rabbit feeding regimes and its effect on growth, carcass characteristics, and meat quality
Authors: Radwan Mohamed A. , Maggiolino Aristide , Hassanien Hanan A. M. , Palo Pasquale D. , El-Kassas Nabila E. M. , Abbas Hassan S. , Salem Abdelfattah Z. M.
Published: February 2023

This study aimed to shed light on the use of mealworm (Tenebrio molitor) frass (TMF) in rabbit diets and its effects on growth performance, blood profiles, rabbit meat quality, and fatty acid profiles. A total of 48 Gabali rabbits were divided equally and randomly into four groups to be fed one of four dietary treatments: a control (T0) group and three TMF groups, which included TMF meal at 1 (T1), 2 (T2), and 3 (T3) %, respectively. The rabbits were fed on isonitrogenous and isoenergetic diets for 11 weeks, and the growth performance data were recorded. Six rabbits per group were slaughtered at the end of the 11th week, then the pharmacochemical parameters and carcass traits were measured, and meat quality and fatty acid profiles were analyzed. The results indicated that the growth performance of different groups was similar (P > 0.05). The levels of globulin, glucose, and alanine transaminase (ALT) were lower in the mealworm frass groups compared with the control group. Carcass traits were not affected by experimental regimes. Fat was higher in the TMF treatment groups, while moisture was lower compared with the control group. The shear force had a lower value in the treatment groups T3 and T2 compared with the control group. The highest values of redness and chroma (color parameter) of rabbit meat were observed in the treatment groups vs. the control group. Moreover, the proportion of total saturated fatty acids in the meat of rabbits that were fed on the T2 and T3 diets was higher compared to those fed on the control (i.e., T0) and T1 diets. Furthermore, the proportion of monounsaturated fatty acid was higher in the T2, T3, and T1 groups vs. T0 rabbits, whereas the PUFA proportions were lower. It could be concluded that frass has great potential to be used as a partial substitute for rabbit diets.
Effective Heart Disease Prediction Using Machine Learning Techniques
Authors: Bhatt Chintan M. , Patel Parth , Ghetia Tarang , Mazzeo Pier Luigi
Published: February 2023

The diagnosis and prognosis of cardiovascular disease are crucial medical tasks to ensure correct classification, which helps cardiologists provide proper treatment to the patient. Machine learning applications in the medical niche have increased as they can recognize patterns from data. Using machine learning to classify cardiovascular disease occurrence can help diagnosticians reduce misdiagnosis. This research develops a model that can correctly predict cardiovascular diseases to reduce the fatality caused by cardiovascular diseases. This paper proposes a method of k-modes clustering with Huang starting that can improve classification accuracy. Models such as random forest (RF), decision tree classifier (DT), multilayer perceptron (MP), and XGBoost (XGB) are used. GridSearchCV was used to hypertune the parameters of the applied model to optimize the result. The proposed model is applied to a real-world dataset of 70,000 instances from Kaggle. Models were trained on data that were split in 80:20 and achieved accuracy as follows: decision tree: 86.37% (with cross-validation) and 86.53% (without cross-validation), XGBoost: 86.87% (with cross-validation) and 87.02% (without cross-validation), random forest: 87.05% (with cross-validation) and 86.92% (without cross-validation), multilayer perceptron: 87.28% (with cross-validation) and 86.94% (without cross-validation). The proposed models have AUC (area under the curve) values: decision tree: 0.94, XGBoost: 0.95, random forest: 0.95, multilayer perceptron: 0.95. The conclusion drawn from this underlying research is that multilayer perceptron with cross-validation has outperformed all other algorithms in terms of accuracy. It achieved the highest accuracy of 87.28%.
Application of Genetics and Genomics in Livestock Production
Authors: Burrow Heather , Goddard Michael
Published: February 2023

The delivery of genomic sequences for most livestock species over the past 10–15 years has generated the potential to revolutionize livestock production globally, by providing farmers with the ability to match individual animals to the requirements of rapidly changing climates, production systems and markets [...]
Nutritional Quality of Milk Fat from Cows Fed Full-Fat Corn Germ in Diets Containing Cactus Opuntia and Sugarcane Bagasse as Forage Sources
Authors: Silva Camila S. da , Gama Marco A. S. , Silva Erick A. M. , Ribeiro Emília F. , Souza Felipe G. , Monteiro Carolina C. F. , Mora-Luna Robert E. , Oliveira Júlio C. V. , Santos Djalma C. , Ferreira Marcelo de A.
Published: February 2023

We evaluated the performance, milk composition, and milk fatty acid profile of cows fed diets composed of cactus cladodes (Opuntia stricta [Haw.] Haw), sugarcane bagasse and increasing levels of full-fat corn germ (FFCG). We hypothesized that ground corn can be effectively replaced by FFCG when cactus cladodes and sugarcane bagasse are used as forage sources. The cows were randomly distributed into two 5 × 5 Latin Squares and fed five diets in which ground corn was progressively replaced with full-fat corn germ (FFCG; 0%, 25%, 50%, 75%, or 100% of substitution). Adding FFCG to the diet increased milk production and milk fat content and reduced milk protein content. Overall, FFCG reduced the proportion of saturated FAs and increased mono- and polyunsaturated FAs in milk, including CLA isomers. In addition, activity indices of stearoyl-CoA desaturase were reduced by increasing levels of FFCG. We conclude that the substitution of corn for FFCG in diets based on cactus cladodes and sugarcane bagasse positively modifies the FA profile of milk and could add commercial value to milk products (e.g., CLA-enriched milk). In addition, the milk fat response indicates that the basal diet was favorable to the rumen environment, preventing the trans-10 shift commonly associated with milk fat depression.
Dietary Alpha-Ketoglutarate Supplementation Improves Bone Growth, Phosphorus Digestion, and Growth Performance in Piglets
Authors: Tian Junquan , Yang Fan , Bao Xuetai , Jiang Qian , Li Yuying , Yao Kang , Yin Yulong
Published: February 2023

Phosphorus (P) pollution from modern swine production is a major environmental problem. Dietary interventions to promote bone growth can improve the utilization of dietary P, and thereby reduce its emission. Recent in vitro studies have shown that alpha-ketoglutarate (AKG) exerts a pro-osteogenic effect on osteoblast cells. This study aimed to evaluate the effects of AKG supplementation on bone growth, P and Ca digestion, and the gut microbial profile in piglets. Thirty-two piglets were randomly assigned into two dietary groups. The piglets were fed a basic diet containing 10 g/kg AKG or 10 g/kg maize starch (control) for 28 days. On days 21–28, titanium dioxide was used as an indicator to determine the apparent digestibility of P. AKG supplementation improved the bone mineral density, length, weight, and geometrical and strength properties of the femur and tibia. Furthermore, AKG supplementation increased apparent ileal and total tract digestibility of P. Colonic microbiota analysis results showed that AKG supplementation increased α-diversity and beneficial bacteria, including Lactobacillus and Clostridium butyricum, and decreased nitrogen fixation and chemoheterotrophy. Together, AKG supplementation improves bone growth, the utilization of dietary P, and the colonic microbial profile, which may provide a nutritional strategy for diminishing P pollution originating from the pig industry.
Influence of Semen Collection Frequency and Seasonal Variations on Fresh and Frozen Semen Quality in Thai Native Roosters
Authors: Pimprasert Maruay , Kheawkanha Theerapat , Boonkum Wuttigrai , Chankitisakul Vibuntita
Published: February 2023

This study aimed to determine the effects of the frequency of semen collection (once, twice, and thrice weekly) and seasonal variations on the fresh and frozen semen quality of Thai native roosters throughout the year. Data on temperature and humidity were collected and used to calculate the temperature–humidity index (THI). The average temperature and THI were lower in the winter than in the rainy season and the summer (p < 0.05). In contrast, the average relative humidity was not different among the seasons but was higher in the rainy season (p > 0.05). None of the fresh or frozen semen quality parameters were influenced by the frequency of semen collection, but the season did have an effect. The highest sperm concentration was obtained in the winter (p < 0.05). In contrast, the lowest sperm concentration was found during the rainy season, which presented the highest humidity. Regarding the frozen semen quality, the highest malondialdehyde concentration and the lowest motility were found in the summer (p < 0.05). In conclusion, semen collection can be conducted thrice per week for a consecutive year without affecting semen quality while maximizing sperm production. However, the highest sperm production was obtained in the winter, which is also a suitable season for producing semen for cryopreservation.
The Total Mercury Concentration in Organs of Eurasian Magpies (Pica pica) and Common Woodpigeons (Columba palumbus) from the Warsaw Municipal Area
Authors: Skibniewska Ewa M. , Skibniewski Michał
Published: February 2023

Mercury is a toxic element widely distributed in the natural environment, affecting animals’ health. It is released into the environment from both natural and anthropogenic sources. The present study analyzed the mercury concentrations in liver, kidney, heart and muscle tissue in two species of birds from the Warsaw area, which were used as bioindicators of local environmental pollution with this metal. The mercury content in the examined samples was determined using atomic absorption spectrometry (AAS) utilizing automatic mercury analyzer type AMA 254. The highest mercury content was found in the body of Eurasian magpies, in which it was 0.025; 0.021; 0.006; 0.0037 and 0.029 mg kg−1 of tissue wet weight for kidney, liver, heart, thigh muscles and pectoral muscles, respectively. In the case of common woodpigeons, the content of this metal was significantly lower, amounting to 0.007; 0.005; 0.002; 0.001 and 0.001 mg∙kg−1 wet weight for kidney, liver, heart, thigh muscles and pectoral muscles, respectively. In light of data from the available literature, the values obtained should be considered low, not causing a risk to animal health. The results obtained indicate low environmental exposure to this element.