bluuebunny/crossref_metadata_2025 huggingface dataset:
UPAYA PENINGKATAN KESEHATAN MASYARAKAT PESISIR CEGAH KOMPLIKASI PENYAKIT DEGENERATIF DAN PINTAR P3K LAUT DI KAMPUNG KALASUGE KECAMATAN TABUKAN UTARA KABUPATEN KEPULAUAN SANGIHE
Authors: Tuwohingide Yanli everson , Gobel Iswanto
Published: November 2023

Kampung Kalasuge terletak diwilayah Tabukan Utara Pulau Sangihe berjarak sekitar 25 km dari kota Tahuna dengan posisi kampung berada di tepi pantai dan mayoritas penduduk berprofesi sebagai Nelayan. Masalah kesehatan yang diidentifikasi yakni kurangnya pengetahuan masyarakat tentang penanganan P3K dilaut dan tingginya angka Penyakit Degeneratif berupa Hipertensi dan Diabetes Militus yang berdampak pada potensi komplikasi berupa Penyakit Jantung Koroner yang merupakan pembunuh nomor 1 di Indonesia. Sehubungan dengan hal diatas tim pengabdi telah melakukan Pengabdian Kepada masyarakat pada tanggal 16 mei 2023, dalam bentuk skreaning penyakit degenerative serta dilanjutkan dengan pemberian materi tentang pencegahan komplikasi penyakit degenerative dan tindakan p3k dilaut yang telah diikuti oleh 30 peserta. Hasil yang ditemukan dalam skreaning yakni 76 Persen mengalami peningkatan kadar asam urat sementara dalam workshop didapatkan peningkatan pengetahuan sebanyak 43 Persen. Kegiatan ini telah dipublikasikan dalam media elektronik Sulut News.com serta ringkasan kegiatan dalam bentuk video. Kesimpulan dalam kegiatan ini yakni terjadi peningkatan pengetahuan masyarakat serta komitmen dari seluruh elemen yang ada dikampung untuk melaksanakan pola hidup sehat.

Kalasuge Village is located in North Tabukan area of ​​Sangihe Island, approximatelly 25 km from Tahuna town, with the position of the village being on the beach and the majority of the population working as fishermen. The health problems identified were the lack of public knowledge about how handling first aid at sea and the high rate of Degenerative Diseases as well as Hypertension and Diabetes Militus which have an impact on potential complications in the form of coronary heart disease which is the number 1 killer in Indonesia. Based on that, the community service team was conducted the event on May 16, 2023. That particular event started with the screening of 30 participants about the degenerative disesase and followed by health education about the prevention of complications of degenerative diseases and how to provide the first aid. The results of the screening showed that 76 Percent participants experienced an increase in uric acid levels.  After the workshop, test result showed the knowledge of the participants were increased 43 Percent. This event has published in the electronic media North Sulawesi News.com also in youtube chanel of Polnustar. The conclusion in this activity is that there is an increase in community knowledge and commitment from all elements in the village to implement a healthy lifestyle.
EDUKASI TERAPI NON FARMAKOLOGIS PEMANFAATAN MENTIMUN DAN JAHE DALAM PENANGGULANGAN HIPERTENSI DI PULAU MARORE
Authors: Tatangindatu Maryati Agustina , Tooy Gracia , Hinonaung Jelita Siska Herlina , Patras Mareike Doherty
Published: November 2023

Salah satu penyakit tidak menular yang seringkali tidak menimbulkan gejala sehingga menyebabkan penderita terbesar tidak patuh dalam melaksanakan pengobatan yaitu hipertensi. Oleh sebab itu, perlu adanya pencegahan terjadinya masalah terkait penyakit hipertensi dan kejenuhan untuk mengonsumsi obat hipertensi setiap hari melalui pemberian edukasi. Tujuan pengabdian ini untuk memberikan edukasi terapi Non farmokologis pemanfaatan jus mentimun dan rendaman air jahe dalam penanggulangan hipertensi di Pulau Marore. Pada tanggal 17 Juli dilakukan kegiatan pengabdian di Aula Kantor Kecamatan Marore. Hasil menunjukkan adanya peningkatan rerata pengetahuan dibandingkan sebelum edukasi diberikan dengan nilai selisih 20,3. Hal ini menunjukkan bahwa pemberian edukasi berpengaruh cukup efektif terhadap peningkatan pengetahuan partisipan. Kesimpulan adanya peningkatan pengetahuan sesudah dilakukan edukasi terapi non farmakologis pemanfaatan mentimun dan jahe dalam penanggulangan hipertensi di Pulau Marore

One of the non-communicable diseases that often does not cause symptoms, causing the majority of sufferers to be non-compliant with treatment, is hypertension. Therefore, it is necessary to prevent problems related to hypertension and boredom from taking hypertension medication every day by providing education. The aim of this service is to provide non-pharmacological therapy education on the use of cucumber juice and ginger water soaks in treating hypertension on Marore Island. On July 17, service activities were carried out in the Marore District Office Hall. The results show an increase in the average knowledge compared to before education was provided with a difference value of 20.3. This shows that providing education has a quite effective effect on increasing participants' knowledge. The conclusion is that there is an increase in knowledge after providing education on non-pharmacological therapy on the use of cucumber and ginger in treating hypertension on Marore Island
ANÁLISE DOS RISCOS LABORAIS EM ÓRGÃO PÚBLICO DE SAÚDE DE FORTALEZA-CE
Authors: Ferreira de Oliveira Danielle , Pereira de Vasconcelos Marina , Saraiva Silveira Araújo Eline , Bezerra de Melo Costa Keyteanne , Carneiro Aguiar Edglesy , Da Silva Costa Tereza Emanuelle
Published: November 2023

Analisar os riscos laborais em órgão público de saúde de Fortaleza-CE. Trata-se de um estudo quali-quantitativo, fundamentado em entrevistas estruturadas em questionário. Foram entrevistados 34 profissionais da Coordenadoria de Vigilância em Saúde, em abril/2023, que avaliaram satisfatoriamente a qualidade de vida no trabalho. Para tanto, foram considerados os parâmetros satisfação, volume de trabalho e concentração na realização da atividade laboral. Entretanto, foram identificados riscos ambientais e ocupacionais, sendo o ergonômico o risco de maior prevalência. Destaca-se, ainda, a importância da construção do mapa de risco como um instrumento norteador na identificação dos riscos que impactam fortemente na saúde do trabalhador. Faz-se necessário pensar em melhorias das condições de trabalho com o intuito de eliminar e/ou reduzir os riscos presentes nas atividades laborais desses profissionais.
EXPLORAÇÃO DO MINÉRIO DE COBRE: IMPACTOS SOCIOECONÔMICOS NA CIDADE DE ALTO HORIZONTE – GO
Authors: De Rezende Paulo Henrique Cardoso , Costa Denilson da Silva , Rezende Sarah Elayne de Freitas , De Almeida Carlos Alberto Vieira , Marques Jocimar Cintra
Published: November 2023

O município de Alto Horizonte tem se destacado nos últimos anos como um dos principais polos de extração de minério em Goiás. Neste sentido, o objetivo geral deste artigo é avaliar, sob diferentes perspectivas, a contribuição da exploração de cobre para o desenvolvimento local da cidade de Alto Horizonte, no estado de Goiás. Para alcançar esse objetivo, foram feitas buscas na web sobre a história da cidade e a empresa que atua na mineração, além de consulta a arquivos relevantes disponibilizados em formato digital e físico. Foram também utilizados livros e artigos como referencial teórico. Por fim, foram analisados dados do Instituto Brasileiro de Geografia e Estatística (IBGE) e do portal das cidades. Os resultados   indicaram que a exploração de cobre tem tido impactos significativos nas questões socioeconômicas da cidade de Alto Horizonte, destacando-se, entre estes resultados o aumento no número de polos de trabalho e renda per capita da população municipal, o aumento populacional e o investimento na educação e na infraestrutura urbana e rural do município.
A MOROSIDADE NA PREVISÃO DO DIREITO DE APRESENTAÇÃO NO ORDENAMENTO JURÍDICO BRASILEIRO E AS CONSEQUENCIAS DA SUA TARDIA MATERIALIZAÇÃO POR MEIO DA RESOLUÇÃO Nº 213/15 DO CONSELHO NACIONAL DE JUSTIÇA
Authors: Perez Giovanna Torres
Published: November 2023

O presente artigo é um estudo teórico sobre a instrumentalização das audiências de custódia no ordenamento jurídico brasileiro. Tem como intuito analisar a introdução e garantia do direito de apresentação do preso à autoridade competente, que se deu pelas Convenções internacionais sobre direitos humanos que foram ratificadas pelo Brasil, fazendo uma análise critica quanto a morosidade na previsão de um instrumento garantidor desse direito, que foi por muitos anos violado. Para isso se faz necessário trazer uma contextualização histórica quanto ao direito de apresentação em outros ordenamentos e a sua introdução nas Convenções Internacionais, a introdução dessas Convenções no ordenamento pátrio e consequente necessidade de reconhecimento do direito de apresentação como direito fundamental, bem como a previsão das audiências de custódia a partir de 2015, com a resolução nº 213/15 que foi responsável pela materialização do direito subjetivo de apresentação, garantindo ao preso sua apresentação pessoal ao magistrado em até 24 horas. Analisa-se também as consequências trazidas por mais de 20 anos de violação do direito de apresentação que ficou esquecido nas Convenções internacionais ratificadas pelo Brasil, vez que esse direito só passou a ser garantido efetivamente com a previsão das audiências de custódia.
Investir dans la transition écologique des villes tout en préservant la mixité sociale, est-ce possible?
Authors: Mayneris Florian
Published: November 2023

Afin de favoriser la transition écologique, les villes investissement dans le verdissement et l’offre de transport collectif sur leur territoire. Or, le verdissement des quartiers et leur connexion au transport collectif conduit, par des mécanismes de capitalisation foncière, à des phénomènes d’ « éco-embourgeoisement ». Pour tenter de concilier le développement durable des villes et la mixité sociale, des pistes de solution existent, notamment l’accroissement de l’offre de logements hors-marché, la réglementation pour influencer le comportement des promoteurs et des propriétaires privés, ou encore la facilitation et l’accélération des processus d’approbation des nouveaux projets immobiliers.
Biotechnology-based Profiling of Lichens and Their Metabolites for Therapeutic Applications
Authors: Srivastava Priyansh , Partha Sarethy Indira
Published: November 2023

Lichens have been inadequately studied for their medicinal value though recent studies have established them as potential sources of bioactive compounds that show antimicrobial, anticancer, antioxidant and neuroprotective properties. Ethnobotanical studies have shown that Pseudocyphellaria aurata, Usnea bismolliuscula, Usnea longissimi, Xanthoparmelia conspersa, Sulcaria sulcate and Solorina crocea have been used by humans since ancient times as a part of their folk wisdom. Recent studies have shown that metabolites from lichens show promising bioactive properties. This review focuses on the necessity for utilizing a modern biotechnology-based approach for elucidating the role and unrealized potential of lichens. Technologies such as genomics, metagenomics, and proteomics have been applied to a far lesser extent in lichens, but the limited studies have revealed the unrealized potential of lichens in modern therapeutics. We attempt to provide a broad overview of the known and unknown in lichen research – ranging from the metabolite production pathways to the genomics and metagenomics, and further to the proteomics and transcriptomics of lichens, the threads of which need to be pieced together to provide a roadmap for further studies.
Teacher Professional Learning, Culturally Responsive/Sustaining Practices, and Indigenous Students’ Success: A Comparative Case-Study of New Zealand and Saskatchewan, Canada
Authors: Papp Theresa , Cottrell Michael
Published: November 2023

Employing a multiple instrumental case study approach, we document and analyze initiatives in Saskatchewan and New Zealand to enhance cultural responsiveness among White educators through professional learning initiatives undertaken as part of broader strategies to animate more equitable educational outcomes for Indigenous students. The findings of this research confirm the capacity of teachers to act as agents of change and highlight the potential of teacher professional learning to catalyze educational reform and innovation, ensuring that schools can indeed benefit students who have historically been underserved by public education. We conclude that the growing Indigenous presence in classrooms is a powerful driver of innovation, which offers the potential to transform curriculum, pedagogy, and teacher-student relationships for the benefit of all learners in these contexts and beyond. Key words: Indigenous students, teacher professional learning, culturally-responsive pedagogy, Saskatchewan, New Zealand En utilisant une approche d'étude de cas instrumentale multiple, nous documentons et analysons des initiatives en Saskatchewan et en Nouvelle-Zélande visant à améliorer la sensibilité culturelle des enseignants blancs par le biais d'initiatives d'apprentissage professionnel entreprises dans le cadre de stratégies plus larges visant à produire des résultats éducatifs plus équitables pour les étudiants autochtones. Les résultats de cette recherche confirment la capacité des enseignants à agir en tant qu'agents de changement et soulignent le potentiel de l'apprentissage professionnel des enseignants à catalyser la réforme et l'innovation en matière d'éducation, garantissant ainsi que les élèves qui ont historiquement été mal desservis par l'éducation publique peuvent effectivement profiter des écoles. Nous concluons que la présence croissante des autochtones dans les salles de classe est un puissant moteur d'innovation qui offre la possibilité de transformer les programmes d'études, la pédagogie et les relations entre enseignants et élèves au profit de tous les apprenants dans ces contextes et au-delà. Mots-clés: élèves autochtones, apprentissage professionnel des enseignants, pédagogie adaptée à la culture, Saskatchewan, Nouvelle-Zélande
Calculation of normal crack opening width of reinforced concrete beams under bending
Authors:   Ufa State Petroleum Technological University, Ufa, Russia, Abdrakhmanova L. K. , Mukhamadiyarov A. V. ,   Ufa State Petroleum Technological University, Ufa, Russia
Published: November 2023

When a reinforced concrete beam deflects, a process occurs that leads to the formation of cracks in the stretched area of the wall. In turn, cracks reduce the strength, bearing characteristics of the beam and, accordingly, have a direct effect on the increase in deflection, which worsens the bearing capacity of the entire structure, and leads to an emergency situation. The article considers the calculation of the opening of normal cracks of a reinforced concrete beam according to the methodology presented in SP 52-101-2003, SP 63.13330.2018, with pre-set parameters of the tested loads and strength characteristics of the beam. Keywords: reinforced concrete beam; normal cracks; strength characteristics.
Sobre premios e incentivos a la jubilación anticipada.
Authors: Sempere Navarro Antonio V.
Published: November 2023

Se discute sobre los incentivos a la jubilación anticipada de los empleados públicos municipales que tienen reconocidos un coeficiente reductor de la edad de jubilación por razón de su actividad. La sentencia comentada concluye que no caben primas, gratificaciones, indemnizaciones o, en general, incentivos por jubilación anticipada para el rejuvenecimiento de la plantilla funcionarial. Esos incentivos tienen naturaleza retributiva y solo proceden si tienen la cobertura de una norma legal general, relativa a la remuneración de los funcionarios de la correspondiente Administración (Local, en el caso de policías municipales). La disposición adicional vigesimoprimera in fine de la Ley 30/1984, de 2 de agosto, de Medidas para la Reforma de la Función Pública, aun previendo medidas de incentivación de la jubilación anticipada, no hizo una regulación precisa para el supuesto de que dichas medidas tuvieran carácter retributivo y, por ello, no satisface la exigencia de que las gratificaciones por jubilación anticipada tengan cobertura en una norma legal de alcance general.

Incentives for early retirement for municipal public employees who have a recognized coefficient reducing the retirement age due to their activity are discussed. The judgment concludes that there is no room for bonuses, gratuities, indemnities or, in general, incentives for early retirement for the rejuvenation of the civil service workforce. These incentives are remunerative in nature and are only applicable if they are covered by a general legal norm relating to the remuneration of civil servants of the corresponding Administration (Local, in the case of municipal police officers). The twenty-first in fine additional provision of Law 30/1984 of 2 August 1984 on Measures for the Reform of the Civil Service, although providing for measures to encourage early retirement, did not make a precise regulation in the event that such measures were remunerative in nature and, therefore, does not satisfy the requirement that bonuses for early retirement be covered by a legal provision of general application.
A Multicriteria Evaluation of Local E-Government in Terms of Citizen Satisfaction
Authors: Tavares Luís V. , Ferreira José A. , Sá Ana M. , Saraiva Ana C. , Moreira Vasco. B. , Mendes Gonçalo M.
Published: November 2023

Any strategy to improve local public administration gives paramount importance to the development of electronic administration (E-Local Government) to facilitate interaction with citizens promoting efficiency, local participation, and sustainable development. This explains the numerous contributions to evaluating websites of local authorities, but they do not focus on modeling the citizen satisfaction induced by their use. This is why three research questions are addressed by this paper: how can such satisfaction be modeled, which attributes be considered and described and how to assess the relative importance assigned by citizens to each attribute?

The level of satisfaction is found to depend on the easiness of use of each site and of the available functionalities to share information, to provide services, and to promote participation. A model based on the Multiattribute Theory and using the OptionCards method is developed to estimate the relative importance assigned by each citizen to each attribute and it is successfully applied to a focus group.

The answers presented by the authors to these questions are applied to a sample of Portuguese websites allowing their benchmarking and the identification of a road map for im-provement. This instrument is applied to a set of Portuguese municipalities revealing a high level of disparity and confirming how important can be its application to assess inter-municipalities benchmarking, to diagnose their LGS major shortcomings and to support the design of a road map for improvement.
Working Capital Management of Catering Enterprises Based on the Supply Chain — Taking the Jiumaojiu Group as an Example
Authors: Guo Guihang , Li Ying , Zheng Yuerong
Published: November 2023

The management of working capital is crucial to the development of a business. In recent years, due to the epidemic, the catering industry has generally suffered from reduced revenue, high costs and financing difficulties. With the increasing competition in the catering industry, it is an important research direction to study the working capital management of listed catering enterprises in China from the perspective of supply chain. As a large catering brand in China, Jiumaojiu was in a poor financial situation in recent years. To better understand and help to tackle the problem existing in the management of its working capital, this paper takes Jiumaojiu Group as a case for study. Based on the working capital management evaluation method proposed by Professor Wang Zhuquan, we analyzed the working capital management of Jiumaojiu Group in recent years from the procurement, production and sales parts of its supply chain. According to the results of financial analysis based on Jiumaojiu Group’s annual reports for the periods from 2018 to 2022, we conclude that, in order to improve the utilization of the funds and the management of the working capital, Jiumaojiu Group need to improve it inventory management capabilities, strengthen the management of its accounts receivable, and slow down its business expansion slightly. It is hoped that this research can provide reference for Chinese catering enterprises to improve their working capital management.
استنباط حركة المعنى عند ابن حُمديس دراسة تطبيقية في المعنى الشعريّ
Authors: مناتي محمود ليلى
Published: November 2023

إنّ هذه الدراسة تحاول  استنباط حركة المعنى وأساليب تشكيله لدى شاعر أندلسي هو ابن حمديس، لأنَّها ترى أنَ كثيراً من الأصوات التي تحدّد الغنائية الصافية في شعر الشاعر والنغمات التي تميزه من غيره من الشعراء في محاولة تأويل بعض أشكاله التي بدت لبعض الدارسين، بأنَّها ليست إلّا رسوماً فنيّة مكّررة ، ممّا جعلها تسقط كثيراً من المقاربات النقدية بفخّ الشكل الشعريّ، فبدأ هذا الشعر وكأنَّه نصّ نمطيّ مكرّرُ، واستند البحث إلى منهج وصفيّ يتابع نصوص شاعر عانى غربة طويلة شاقّة، ويحفر في تجلّيات صورها ويثير نوعاً من الحوار المعرفي المبني على دراسة هذه النصوص ضمن سياقها الفني وليس في إطار مكانيّ وزمانيّ ضيقين.
Impacts of natural and anthropogenic factors on soil erosion
Authors: Gantulga Nomin , Iimaa Tuyajargal , Batmunkh Munkhjin , Surenjav Unursaikhan , Tserennadmin Enkhjargal , Turmunkh Telmen , Denchingungaa Dorjgotov , Dorjsuren Batsuren
Published: November 2023

Soil erosion is a serious issue that is caused by both natural and anthropogenic factors. Natural processes, including water and wind erosion, as well as higher temperatures, have been identified as leading causes of soil erosion. Additionally, anthropogenic factors, such as urbanization, road construction, agriculture, industry, mining, and others significantly contribute to this problem. These factors have resulted in the loss of biological productivity of the land and have inflicted damage on the entire ecosystem. Since 2000, soil erosion and desertification have become even more severe, exacerbating the problem. The soil of Mongolia, characterized by an arid and semi-arid climate with low precipitation and high temperature fluctuations, is highly susceptible to erosion with approximately 55% of it being classified as high or very easy to erode. This review provides a comprehensive overview of the natural processes and anthropogenic factors that contribute to soil erosion, as well as the current status of soil in various regions of Mongolia.
Organizational Commitment, Psychological Capital, and Job Burnout among Teachers: Closer Focus on Job Sector
Authors: Perveen Shagufta , Riaz Ahsen , Bano Sadia
Published: November 2023

The extent to which a person identifies with and actively participates in each organization is referred to as their organizational commitment, which is the attitude that influences employee behavior beneficial to the organization. The present study was designed to investigate the connection between job burnout, organizational commitment, and psychological capital among government and non-government officials. It also aimed to find out demographic differences, i.e., (job sector, gender, and job experience) in organizational Commitment, psychological capital, and job burnout among government and non-government officials. In the present research, data was collected using the Maslach Burnout Inventory, psychological capital, and organizational commitment scales from a conveniently selected sample of 400 teachers from different colleges in Mansehra, Haripur, and Abbottabad. The study's findings suggested a significant positive relationship between organizational commitment and psychological capital, whereas job burnout is significantly negatively associated with organizational commitment and psychological capital among teachers. Teachers affiliated with government institutions reported more job burnout, whereas non-government teachers scored high on psychological capital and organizational commitment. Female employees and employees with more than five years of job experience exhibited higher levels of job burnout and organizational commitment.
Sway ratio – a new measure for quantifying postural stability
Authors: Błaszczyk Janusz
Published: November 2023

In the search of a reliable postural stability index, two sway time series: the center-of-mass (COM) and the center-of-foot pressure (COP) were recorded simultaneously in elderly subjects standing quiet with eyes open and with eyes closed. From a battery of commonly use sway measures, only the anteroposterior COM and the COP path lengths proved their high sensitivity and discriminative power to the imposed vision conditions. Based upon these indices, a new measure – sway ratio (SR) – was computed, as the COP-to-COM path length ratio. The measure can easily distinguish vision vs. no vision in the elderly. The SR can be successfully accessed base upon the COP signal only. In contrast to traditional sway indices, the SR as a relative measure is insensitive to the length of sampled record and to the signal sampling frequency. Its magnitude can be interpreted as an average amount of balance controlling motor activity that coincides with a unit COM displacement. The SR is recommended as a reliable measure that allows for assessment of postural stability.
The effects of chronic corticosterone on hippocampal astrocyte numbers: A comparison of male and female Wistar rats
Authors: Bridges* Nikola , Šlais Karel , Syková Eva
Published: November 2023

Chronic stress and/or glucocorticoid administration produces atrophy of hippocampal neurons. However, evidence of the impact of glucocorticoids on glial cells, especially in both males and females, is limited. In the present study, we investigated the total percentage body weight, hippocampal volume and hippocampal astrocyte numbers following chronic corticosterone treatment in male and female Wistar rats. Males had greater left and right hippocampal volumes overall, but no effect on hippocampal volume was seen after corticosterone treatment. Total body weight was dose-dependently lower in both sexes, but the decrease was more prominent in male rats. Corticosterone treatment dose-dependently increased astrocyte numbers in the CA1 region, but not in the lateral and medial CA3 hippocampal regions. This increase was similar in both male and female rats. The astrogliosis observed following chronic corticosterone may have implications for extrasynaptic communication and neuron-glia interactions and is similar to changes in the astrocytic population observed in aged rats.
Emotion-dependent modulation of interference processes: An fMRI study
Authors: Sommer* Monika , Hajak Göran , Döhnel Katrin , Meinhardt Jörg , Müller Jürgen
Published: November 2023

We studied the effects of experimentally induced emotions on inhibitory control using functional magnetic resonance tomography (fMRI). The Simon task used involves two conditions with different attentional demands and is a well established paradigm for studying inhibitory control. Incompatible trials demand cognitive control for resolving interference. Compatible trials need no inhibitory control. Twelve participants viewed a series of affective pictures inducing positive, negative or neutral affects. Between the picture blocks, participants performed either incompatible or compatible trials. Behavioral and fMRI data revealed an impact of negative emotions only on the processing of ncompatible trials. Subjects made more errors and showed less activation of brain areas associated with task performance. There was no effect of positive emotions neither on compatible nor incompatible trials. The results first showed that especially the processing of negative emotions is resource competing and secondly that the competition
concerns only the controlled route of cognitive processing.
Molecular mechanisms of dendritic spine development and maintenance [Review]
Authors: Sala* Carlo , Cambianica Ilaria , Rossi Francesca
Published: November 2023

The large majority of excitatory synapses are located on dendritic spines which are discrete membrane protrusions present on neuronal dendrites. Interestingly the highly heterogeneous morphology of dendritic spines is thought to be the morphological basis for synaptic plasticity associated to learning and memory formation. Indeed dendritic spines structure is regulated by molecular mechanisms that are fine tuned and adjusted according to level and direction of synaptic activity, development, specific brain region, and different experimental behavioral conditions. This supports the idea that reciprocal changes between the structure and function of spines impact both local and global integration of signals within dendrites. An
increasing number of proteins have been found to be morphogens for dendritic spines and provided new insights into the molecular mechanisms regulating spine formation and morphology. Thus determining the mechanisms that regulate spine formation and morphology is essential for understanding the cellular changes that underlie learning and memory in normal and pathological conditions.
CDP-choline (citicoline) attenuates brain damage in a rat model of birth asphyxia
Authors: Fiedorowicz Michał , Makarewicz Dorota , Stańczak-Mrozek Kinga , Grieb Paweł
Published: November 2023

To estimate protective potential of citicoline in a model of birth asphyxia, the drug was given to 7-day old rats subjected to permanent unilateral carotid artery occlusion and exposed for 65 min to a hypoxic gas mixture. Daily citicoline doses of 100 or 300 mg/kg, or vehicle, were injected intraperitoneally for 7 consecutive days beginning immediately after the end of the ischemic-hypoxic insult, and brain damage was assessed by gross zorphology score and weight deficit two weeks after the insult. Caspase-3, α-fodrin, Bcl-2, and Hsp70 levels were assessed at 0, 1, and 24 h after the end of the hypoxic insult in another group of rat pups subjected to the same insult and given a single dose of 300 mg/kg of citicoline or the vehicle.
Citicoline markedly reduced caspase-3 activation and Hsp70 expression 24 h after the insult, and dose-dependently attenuated brain damage. In the context of the well-known excellent safety profile of citicoline, these data suggest that clinical evaluation of the efficacy of the drug in human birth asphyxia may be warranted.
Patterned growth and differentiation of human cord blood derivedneural stem cells on bio-functionalized surfaces
Authors: Bużańska Leonora , Ruiz Ana , Zychowicz Marzena , Rauscher Hubert , Ceriotti Laura , Rossi Francois , Colpo Pascal , Domańska-Janik Krystyna , Coecke Sandra
Published: November 2023

Bio-functionalized surfaces were prepared to study the adherence and differentiation capacity of neural stem cells derived from human umbilical cord blood (HUCB-NSC). Cell growth platforms containing arranged arrays of adhesive molecules were created by microcontact printing on a biologically inert surface. Biomolecules used to prepare microarray platforms included the extracellular matrix protein fibronectin and the polyaminoacid poly-L-lysine. HUCB-NSC plated on microplatforms at various serum conditions showed serum and molecule type dependent capacity for adhesion and differentiation. Poly-L-lysine allowed the maintenance of stem-like non differentiated cells attached to the surface, whereas fibronectin promoted spreading and neural commitment. Serum deprivation did not influence the attachment of HUCB-NSC to fibronectin, but significantly enhanced the attachment to poly-L-lysine and promoted dBcAMP induced neuronal differentiation. A bio-pattern of squares with interconnecting lines was used to guide neuronal differentiation by directing cell protrusion outgrowth. Tailoring the geometry of the bio-pattern enabled directing and monitoring of the neural stem cells. development in the large scale multiparameter biotests.
Neurogenesis in gerbil hippocampus following brain ischemia: Focus on the involvement of metalloproteinases
Authors: Wojcik Luiza , Sawicka Aleksandra , Rivera Santiago , Zalewska Teresa
Published: November 2023

Accumulating evidence indicates that cerebral ischemia enhances neurogenesis in the adult brain. The mechanisms responsible for stem-cell development are poorly understood. Recent in vitro studies indicate the involvement of metalloproteinase (MMPs) in the regulation of proliferation and differentiation of neural progenitor cells. To elucidate if MMPs participate in neurogenesis-associated processes after ischemic insult, we aimed to establish spatial and temporal relationships between neural stem-cell development and the activity of MMPs in the adult brain hippocampus. Our results show that post ischemic acceleration in the proliferation of progenitors in the dentate gyrus is accompanied by increased activity of MMPs. On the contrary, in the damaged CA1 pyramidal layer the neurogenesis seems to be rather elusive.Simultaneously, the activity of MMPs fell below the control level. In conclusion, our results show that the activation of MMPs may, at least in part, contribute to ischemia-induced neurogenesis in the dentate gyrus of the adult brain.
Aneuploidy, chromosomal missegregation, and cell cycle reentry in Alzheimer's disease
Authors: Zekanowski Cezary , Wojda Urszula
Published: November 2023

Alzheimer's disease (AD) is a neurodegenerative disorder with a complex etiology and pathogenesis. Chromosome missegregation was proposed two decades ago to be responsible for neurodegeneration in AD patients. It was speculated that the aneuploidy is a result of aberrant cell cycle of neuronal progenitors during adult neurogenesis and/or of mature neurons. There is mounting evidence of increased rate of general aneuploidy and cell cycle reentry in the AD patients' brains, with area-specific pattern. In this review, we discuss the involvement of chromosome instability, genome damage and cell cycle impairment in AD pathology.
Paradoxical form of filled/empty optical illusion
Authors: Wackermann* Jiri , Kastner Kristina
Published: November 2023

The filled/empty illusion (Oppel-Kundt) is one of the oldest geometrical-optical illusions, but the determinants of the illusion are not yet sufficiently understood. We studied magnitude of the illusory effect as a function of the height of vertical strokes subdividing a spatial extension of fixed length, using the psychophysical standard-variable matching paradigm. For vertical strokes shorter than, or of the same height as strokes delimiting the standard, the length was over-reproduced consistently with earlier studies of the illusion. However, for vertical strokes three times longer than the delimiters, the illusory effect paradoxically decreased, and attained negative values in two of six subjects. The magnitude of the effect thus depends on the patterning of the space between the delimiters, not merely on the number of subdividing elements.
IMPLEMENTASI TEORI-TEORI BELAJAR DALAM PEMBELAJARAN PENDIDIKAN AGAMA ISLAM
Authors: Hatija Muna
Published: November 2023

This study aims to find the concepts and types of learning theory, describe the application of learning theory in PAI learning, and analyze the advantages and disadvantages of learning theory in PAI learning. The method applied in this study is a qualitative research method with a type of literature review. The result of this study is the concept of learning theory’s' was a theory that is used in the learning process in the classroom and outside the classroom that begins with designing the proper method. Various learning theories are Behavioristic, Cognitive, Constructivist, and Humanistic. Its application in PAI learning is that behavioristic theory makes it easier for educators and students in learning process. The cognitive theory implementation in PAI learning can also manifest noble character in students by adhering to the base sources of Islamic teachings. The application of constructivist theory in learning can be done through the five senses, experience, and the environment that will give birth to new knowledge constructions. At the same time, this humanistic theory can be used as a role model in PAI learning to humanize humans. Every theory applied in the PAI learning process certainly has advantages and disadvantages. The advantages and disadvantages of each approach in its application in PAI learning allow an educator to use all theories in a lesson, its goal is to complement one theory with other.
Pengembangan Kompetensi Bahasa Inggris Guru di SD Muhammadiyah 5 Porong
Authors: Taufiq Wahyu , Agustina Sheila , Novita Dian
Published: November 2023

Community service activities aimed at teachers in the Muhammadiyah 5 Porong Elementary School in the form of training and mentoring of English language materials are based on the need for the application of the use of English in the school environment, especially since English has become a local content lesson. This service activity is carried out for 6 months. In this activity, training and mentoring is(Permatasari, Ressa Dwi Citra; Taufiq, 2021) centered on three main materials, namely the use of English in the classroom, namely the use of English that can be inserted or included in the material taught by the teacher. The second material is English for activities outside the classroom, namely interaction activities between teachers and students outside of class hours and the third is English for daily communication, which can be practiced between teachers on various occasions within the school. The teachers are very enthusiastic about this activity, and it is hoped that there will be follow-up activities related to the material taught later. Furthermore, it is hoped that after this activity, teachers will be able and brave to teach in English, using it in school activities and in daily activities to support the use of English in schools.
Pentingnya Jiwa Wirausaha Bagi Karang Taruna Kel. Tawangmangu, Kecamatan Tawangmangu, Kabupaten Karanganyar
Authors: Suprayitno Suprayitno
Published: November 2023

This extension activity was conducted for Karang Taruna Kel. Tawangmangu, Kec. Tawangmangu, Kab. Karanganyar. The outcomes of this activity are cheap participants' knowledge of the concept of entrepreneurship so that they have the right knowledge; benefit participants' insights on how to start a business and choose the right type of business; benefit participants' insights about possible business failures and ways to enter and resolve business failures. This activity is carried out with the following stages: Selection of participants to the community service, namely the board and members of Karang Taruna; Submission of lecture materials, with a view to fostering an entrepreneurial spirit; Implementation of evaluation Evaluation is done: before counseling conducted a question-answer to know each participant's initial knowledge about entrepreneurship special techniques or how to start a business. After the counselor finished the question and answer again about the same material. By comparing the results of answers that have been done, it will be known whether there is an increase in knowledge about entrepreneurship and scope.
Pelatihan Pembuatan Preparat Segar Bagi Guru Biologi Sekolah Menengah Atas
Authors: Welsiliana Welsiliana , Wiguna Gede Arya , Makin Florian Mayesti Prima Remba , Tnunay Ite Morina Yostianti , Pardosi Lukas , Hanas Dicky Frengky
Published: November 2023

Learning media is anything that can be used to convey messages or information in the teaching and learning process so that it can stimulate students' attention and interest in learning. One of the media in biology learning is preparation. Preparations are preparations in the form of organs, tissues, cells, and or bodies of organisms that are preserved or fresh so as to provide convenience for studying, observing, or researching. The purpose of this service activity is to provide training to make fresh preparations for high school biology teachers. The results of this activity include presentation of material on preparations, training on making fresh preparations, and observing fresh preparations that have been made under a microscope. This activity provides new and practical experiences for biology teachers and increases knowledge and enthusiasm for doing simple practicals
Pendampingan Pendirian UMKM Olahan Tahu di Dusun Cerme, Desa Gentong, Ngawi, Jawa Timur
Authors: Ardiyanti Dwi , Purwati Dwi , Amalia Wafi , Azmil Rosidah , Syifa Annisa , Zaldrin Aegis , Maharani Alivia
Published: November 2023

Tofu is raw food made from soybean. It takes 2 -3 hours to process the soybean until finish. The workshop aimed to discuss with the owner of tofu factory that it will be dregs into further process to be snack with higher value. The method used is mentoring and socialization of programs for one month in the community, the workshop then begins with cooking process, by authors. Then, the companion aldo held from process of tax civil number (NPWP), number Business Registration Number (NIB),  until the companion of making account in digital marketing and packaging. Tofu will be sold through online shopping platform by the means of halal-licensed for this tofu snacks. So far, people only process tofu which served as dishes and tofu reside then isn’t been process, directed to sell . In fact, the kind of production is just make little sum of money for the factory owner. This workshop has goals to increase their income. Based on community empowerment to process the tofu reside. Thus, the result from this workshop and accompaniment will be beneficial for community in the Cerme hamlet who have been relying on agricultural products with three harvests a year. Further, people will no longer depend on agricultural products but they can tofu dregs into high-value preparations with the creativity of these processing, such as tofu chips, tofu crackers and tofu sticks.
Pembinaan Kepada Anak Remaja PPA ID 0622 Takong Tentang Pengajaran Siapa Yesus dan Amanat Agung Tuhan Yesus
Authors: Sinaga Rajokiaman , Warni Rosma
Published: November 2023

Teaching about who Jesus is and the Great Commission of the Lord Jesus is a part of Christian life that cannot be ignored. Just like the Lord Jesus always gave teachings about who Jesus was and his purpose for coming to this world. It is very important for youth as the church generation to understand and have an understanding of who Jesus really is and the Great Commission of the Lord Jesus. In this regard, this Community Service (PkM) activity journal focuses on fostering teaching about Who Jesus is and the great Message of the Lord Jesus to teenagers PPA ID 0622 Takong. This activity is a means to equip the correct understanding for teenagers PPA ID 0622 Takong. So that teenagers can have a correct understanding and can apply it in everyday life.
Retinopatia da prematuridade: a importância da triagem e tratamento da doença
Authors: Moreira Herundino Neto Moura , Nunes Heliana Helena de Moura , Moreira Wanúbya do Nascimento Moraes Campelo , Malveira Salma Saraty
Published: November 2023

A Retinopatia da Prematuridade (ROP) é uma doença vaso-proliferativa, curável, não transmissível e multifatorial, decorrente da imaturidade vascular da retina de recém-nascidos prematuros. Atualmente, é a principal causa de cegueira infantil evitável do mundo. Nesse contexto, ressalta-se a necessidade de implantação de serviços de triagem e tratamento oftalmológicas para a prevenção de sequelas da ROP. Objetivo: Analisar a importância do serviço de triagem e tratamento da Retinopatia da Prematuridade na prevenção de sequelas visuais nos recém-nascidos. Metodologia: Trata-se de um estudo documental retrospectivo, transversal, com análise descritiva e abordagem quantitativa de caráter censitário. A pesquisa foi realizada a partir de dados coletados em prontuários na Fundação Santa Casa de Misericórdia do Pará (FSCMP). A seleção amostral que foi utilizada na pesquisa correspondeu a amostra total dos prontuários de neonatos nascidos na unidade hospitalar de janeiro a dezembro de 2021. A coleta dos dados foi obtida após a submissão e aprovação do Comitê de Ética em Pesquisa com Seres Humanos (CEP), além da autorização da instituição onde se realizou o estudo. Resultados e discussão: No ano de 2021 nasceram na FSCMP 8.077 crianças, dessas, 258 recém-nascidos possuíam <1500 gramas e/ou < 32 semanas gestacionais, sendo 100% deles triados durante a internação ou pós alta para a ROP pelo serviço de Detecção e Tratamento da Retinopatia da Prematuridade da FSCMP. A ROP foi identificada em 50,8% recém-nascidos triados, os principais fatores de risco encontrados foram a oxigenoterapia com 75,4%, muito baixo peso com 55,4% e a muito prematuro com 63,4%. Ademais, ressalta-se que 100% dos pacientes com o diagnóstico de ROP evoluíram para a Alta, desses 77,8% obtiveram regressão da ROP de forma espontânea, sem tratamento e 22,2% necessitou de algum tipo de terapêutica. Conclusão: O serviço de triagem e tratamento da ROP da FSCMP é essencial para a prevenção de sequelas visuais nos recém-nascidos no estado do Pará, logo, é necessário de implantação de novos serviços voltados para esta patologia nos hospitais estaduais para que mais crianças que necessitem dele possam ter uma assistência eficiente.
Síntese de Glicoamilase em cultivo líquido e semissólido de fungos do gênero Aspergillus: uma análise das abordagens recentes da produção científica especializada
Authors: Röder Celise , Climaco Letícia Rosa , Olivo José Eduardo
Published: November 2023

As glicoamilases são enzimas com aplicação ampla em diversas indústrias, incluindo alimentos, bioetanol, têxteis e biotecnologia. Este artigo reúne uma análise abrangente de estudos recentes que investigam a produção, purificação e caracterização de glicoamilases a partir de cepas de fungos do gênero Aspergillus. Os estudos enfatizam a otimização das condições de cultivo, a seleção de substratos econômicos, a avaliação da termoestabilidade e a caracterização das propriedades bioquímicas dessas enzimas. Os resultados dos estudos revelam o potencial dessas glicoamilases em uma variedade de aplicações industriais. Suas características, como termoestabilidade, ampla especificidade de substrato e resistência a condições adversas, as tornam ferramentas valiosas na indústria. Além disso, a utilização de resíduos agrícolas como fonte de carbono para a produção de glicoamilases demonstra a importância da sustentabilidade e da economia de recursos na biotecnologia industrial. Essas pesquisas fornecem insights valiosos para o desenvolvimento de produtos mais eficientes e sustentáveis, e enfatizam o potencial inexplorado das glicoamilases de Aspergillus. Em resumo, este estudo destaca a relevância e o impacto promissor dessas enzimas na indústria, com implicações significativas para inovações futuras na biotecnologia industrial.
Análise de sistemas com diferentes meios de produção na cultura da alface
Authors: Alcântara Marcos Bruno Costa , Dos Santos Igor Palheta , Lélis Alexandre da Trindade , Da Silva Gleiciane Pires , Costa Gabriela Gomes , Da Silva Félix Lelis , Da Silva André Luiz Pereira , Gomes Maryjane Diniz de Araújo
Published: November 2023

A produção agrícola mundial de hortaliças é cada vez mais crescente, a produção convencional apresenta custo inicial relativamente baixo, em frente a outros modos de produção, todavia a qualidades e perdas na produção podem tornar-se obstáculos para a renda do agricultor. Neste contexto, o agricultor começa a entender a necessidade de conhecer os sistemas produtivos que se adaptam às condições climáticas e que possuam retorno econômico. Portando, urge a necessidade de avaliar os diferentes sistemas produtivos de hortaliças, afim de viabilizar um diagnóstico da implementação destes sistemas. Diante dos indicadores e dimensões analisadas as vantagens, a curto e médio prazo, torna o sistema de cultivo hidropônico um modo de produção não só viável ao seu investimento, como também produtivo em termos comparativos.