bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengaruh Social Media dalam Membentuk Loyalitas Terhadap Film di Bioskop dengan Mediasi Movie Coolness serta Pengalaman Menonton Film
Authors: Yusuf Farrel , Rahajeng Hadiprawoto Triana
Published: January 2024

In 2022 the Indonesian film industry experienced a revival after two years of being affected by the COVID-19 pandemic. Restrictions imposed during pandemic and the changes of consumer behavior have increased the reliance on social media as information provision channel. The phenomenon also transpires in the practice of movie marketing. The purpose of this study is to examine the utilisation of social media as a movie marketing tool by investigating the mediating effects of movie coolness and cinematic experience on movie loyalty. Moreover, this study focuses on the recent Indonesian highest box office movie, KKN in Dancer Village movie. In doing so, this study integrate a framework of social media information dimensions (i.e., interestingness, value added, information amount, virtual appearance) and social media contents (i.e., advertising and promotion), and analyse their impacts on movie coolness, movie experience, and movie loyalty. This study collected 236 respondents and analyzed the data using SEM (Structural Equation Modeling) using SmartPLS 4.0. The finding suggest that the amount of information and social media content are significant drives of movie experience which lead to a loyaltu to a movie. The results of this study can provide insights to better plan marketing activities of Indonesia movies. In addition, this research contributes to the progress of literature in social media marketing and movie marketing.
Pengaruh Promosi dan Kualitas Pelayanan terhadap Keputusan Pembelian melalui Peran Mediasi Citra Merk di McDonald's Palangka Raya
Authors: Budiman Bancin John , Eka Damayanti Nurlia , Aprilita Aprilita , Josefina Novalina Banurea Joice
Published: January 2024

Business development requires companies to have a competitive advantage in order to compete with their competitors. Nowadays, consumers are more selective in making purchases to fulfil their needs and desires. Therefore, it is important for companies to implement marketing strategies that are oriented towards competitive advantage in order to attract potential market. Based on research conducted by the Frontier Consulting Group, it is known that McDonald's Top Brand Index (TBI) is ranked 2nd with the TBI value of 25.40%. McDonald's is still below its competitor KFC with the TBI value of 27.20%. The top brand index is an indicator of a brand's performance based on 3 criteria in its assessment, namely mind share, market share and commitment share. This study aims to determine the effect of promotion and service quality on purchasing decisions at McDonald’s Palangka Raya with brand image as the intervening variable. The sampling technique in this study uses the Cochran formula so that the sample size was obtained 100 respondents. The results showed that promotion, service quality and brand image each had a positive and significant effect on purchasing decisions at McDonald’s Palangka Raya. Then, in the mediation test, brand image didn’t become the intervening variable and was unable to mediate variable promotion and service quality in this research model.
Pengaruh Modal Manusia dan Pengembangannya terhadap Kinerja Auditor Kementerian Kelautan dan Perikanan
Authors: Septina Suyanti Dungdung , Muljono Pudji , Vitayala S.Hubeis Aida
Published: January 2024

Auditors are internal supervisors whose role is to provide assurance and consultation so that the Ministry of Marine Affairs and Fisheries' programs, activities and budgets are carried out transparently and accountable. Good auditor performance can improve organizational performance and encourage the implementation of good governance. This study aims to analyze the characteristics of human capital and human capital development that affect the performance of auditors of the Ministry of Marine Affairs and Fisheries. The sampling technique uses non probability sampling. The type of non probability sampling used in this study is saturated sampling where all respondents are used as examples. The data were analyzed with descriptive statistics and Structural Equation Modeling Partial Least Square (SEM-PLS) analysis by first testing the questionnaire through validity and reliability tests. The results showed that auditor performance is not influenced by human capital development but has a significant important role for human capital. Human capital development indicators that are best reflected in a row are on-the-job training, career support and off-the-job training. Good human capital plays an important role for auditors in meeting work quantity, time and quality targets. This study also found that human capital can mediate the effect of human capital development on auditor performance. Knowledge, experience, professional proficiency and personality traits are important human capital indicators in this study.
Analisis Faktor yang Berkontribusi dalam Pengembangan Wisata Halal dari Sudut Pandang Wisatawan di Jabodetabek
Authors: Eria Putri Angghina , M Munandar Jono
Published: January 2024

Halal product trends are expanding from food to lifestyle, namely halal tourism. The development of halal tourism is driven by the large Muslim market in the world. Indonesia as the country with the largest Muslim population. The halal tourism authority, CrescentRating, awards Indonesia as the first best halal tourist destination in the OIC category. Jakarta is the fourth best halal tourist area in Indonesia, which in its development has a coordination chain with the surrounding areas, namely Bogor, Depok, Tangerang and Bekasi. Jabodetabek contributes greatly to the country's economy so that there is a need for the development of tourism in Jabodetabek. Therefore, it is necessary to adjust the needs of tourists in order to increase tourist attraction. This study aims to identify the characteristics of tourists and analyze the factors that contribute to the development of halal tourism through 46 indicators of halal tourism. Data were analyzed using a factor analysis tool through SPSS software. The results showed that there were 11 new factors formed from the point of view of archipelago tourists and 14 new factors formed from the point of view of foreign tourists so that there were differences between tourists in the practice of halal tourism.
Modifikasi Algoritma Edmonds Karp untuk Menentukan Aliran Maksimum Pada Jaringan Distribusi Air PDAM (Studi Kasus Jaringan Telaga Sari PDAM Giri Menang Mataram)
Authors: Hotimah Husnul , Bahri Syamsul , Awalushaumi Lailia
Published: January 2024

Clean water is the main and basic need for humans which is of concern to the government. Distribution network system is a very important part to delivering water to all consumers. The lack of water discharge distribution in several areas, especially at the end of the pipeline service, is cause by not optimal water distribution, the flow rate of sorce and leak in pipeline effect. This research has to analyze the optimal network model and determine the maximum flow rate  from the PDAM pipeline using modified Edmonds Karp algorithm. Modified Edmonds Karp algorithm is a method for calculating maximum flow of a network. Based on analysis of modified Edmonds Karp algorithm there is a less efficient us of pipe in PDAM network and result of maximum flow from the network is 202,30 liter/second. This means it can be adding flow discharge to the water distribution pipe by PDAM for expedite the flow to consumer with the addition of flow should not exceed 202,30 liter/second.
Modifikasi Protokol Routing DSDV Menggunakan Algoritma Dynamic-power transmission untuk Mengurangi Interferensi Sinyal dalam Pengiriman Data Berdasarkan Tingkat Kepadatan Node di Jaringan MANET
Authors: Hidayat Jatmika Andy
Published: January 2024

Mobile Ad-Hoc Network (MANET) is a decentralized collection of nodes that exchange information temporarily via wireless transmission. When nodes communicate, all nodes in the communication range will be affected by signal interference from other nodes. The problem that arises due to this signal interference is that it will affect or interfere with the signal transmitted to the receiver, resulting in a decrease in network performance which will impact the quality of service (QoS). To overcome the problem of signal interference, use interference management. This study applies the Dynamic-Power Transmission (DPT) algorithm to the Destination Sequence Distance Vector (DSDV) routing protocol framework. DPT-DSDV will adjust the communication range automatically based on the node density level. When a node sends data packets to neighbouring nodes, the communication range will be adjusted automatically based on the selected level. The performance of DPT-DSDV will be compared with standard DSDV and standard AODV by looking at performance based on three parameters, namely throughput, packet delivery ratio (PDR), and end-to-end delay. Based on the results of research trials, applying the dynamic-power transmission algorithm can improve the performance of the standard DSDV routing protocol. Throughput results on DPT-DSDV increased by 0.90%. The packet delivery ratio (PDR) increased by 0.50%, and end-to-end delay decreased by 2.80%.

Key words: MANET, Interference, Quality of Service, Routing, DSDV, Dynamic-Power Transmission.
Analisis Kebutuhan Dataset Algoritma Speech To Text Bahasa Sasak Menggunakan Perbandingan Data Suara Bahasa Inggris Pada Metode CNN
Authors: Widya Bayu Pratiwi  , Arik Aranta  , Gibran Satya Nugraha
Published: January 2024

Currently, there have been many studies on speech recognition or speech to text. Speech to text is a technology used to convert human speech or voice and translate it into written text. Some speech to text research that has been done, has obtained an accuracy rate of up to 95% with English datasets using the Mel Frequency Coefficient (MFCC) feature extraction method and the Convolutional Neural Network (CNN) classification method. This research will apply similar algorithms, namely MFCC and CNN by displaying the training process and the resulting accuracy in its processing with an analysis scenario using datasets in multiples of 50, 150, 250, and 350 voice data. The results obtained have achieved 95% accuracy on the training data of 350 English voice data. The analysis carried out is to find the best composition on the Sasak language dataset by comparing the accuracy of the test results with the accuracy of the previous training results on the English dataset. From the training and testing process that has been carried out, the results obtained show that the best dataset composition for Sasak language is with nine speakers. This illustrates that the Sasak language requires less human resources compared to the English dataset which involves more than 30 speakers in 50 words. This has a positive impact on saving resources and time required in the development of Sasak language speech recognition system.
Artificial Intelligence in Chatbot Website Platform
Authors: Puspitasari Agreianti , Fajariyanti Yeni , Pusparisti Myrtana , Amborowati Agustin , Tafdhil Muhammad
Published: January 2024

In computing discourse, a Chatbot is a computer programme that is specifically designed to simulate an interactive communication or conversation. The interactive communication is from the machine to the user (human) either through text media, sound media or visual media. Chatbots have been widely used for practical purposes such as online assistance, personalised services, or information acquisition, including in the world of global marketing. The purpose of this research is to describe how a chatbot platform provides its best function in supporting a marketing task of a corporation at a global level. The methods used in this research are: 1) System Analysis, which is the collection of information needed in building the system must be done in detail. Where this information will support all the components needed to obtain results that are in accordance with all the needs related to the design of the system to be input, 2) Preparation of flowcharts, namely the design by entering data on the status of conversations that are commonly carried out by the Help-Desk with customers. Where when the user enters a word or sentence in the column that is already available in the system, a word or sentence search process will be carried out based on the noun, this process is useful for matching whether the input given by the user is in the set of nouns that have been trained in dialogue flow. The result obtained is that the website becomes one of the company's main media in marketing its products because the website already includes all information related to the product and also related to the company. However, when using the website alone, there is no direct communication with potential buyers. Therefore, this research will develop a chatbot that can improve the performance of the Spicering ltd website.
Sustainable Education and Student Action: Understanding Student Contributions to Addressing Climate Change
Authors: Damanik Fritz Hotman Syahmahita , Saliman Saliman
Published: January 2024

This study aimed to identify new factors in sustainable education that are able to motivate students for action related to climate change, and to evaluate the influence of the student movement for climate change on student actions. This research was conducted through a literature review research method. This research provides an explanation of existing findings and data. The results show that formal education in schools and social activities, such as interactions between students, can form a culture that supports sustainable collective action. An evaluation of the student movement in climate change mitigation, including activities such as recycling and waste collection, provides insight into its positive impact. This research contributes to designing educational approaches that motivate and evaluate student action on climate.
Water Quality Analysis in the Batang Ombilin River, Sawahlunto City
Authors: Monica Fitrya , Umar Iswandi , Dewata Indang , Barlian Eri
Published: January 2024

The decline in water quality is caused by pollution pressure due to low environmental sanitation efforts. Water quality can be determined by carrying out certain tests on the water. This research was conducted on the Batang Ombilin River, Sawahlunto City. This research was conducted in October 2022. This research used survey methods and laboratory test methods. Activities carried out using the survey method are in the form of interviews related to research. Next, laboratory test methods are used to analyze water quality. Interview activities were carried out with people living around the Batang Ombilin River. Respondents were determined using random sampling. Samples were taken of 2 liters of water and carried using plastic bottles. The parameters used to see water quality are TDS, TSS, pH, DO, BOD and COD. Based on research that has been carried out, the results show that 65.25% of respondents stated that the existing water is suitable for consumption but must be filtered and purified first before cooking. Meanwhile, 30.75% of respondents stated that it was not suitable for consumption because the water was cloudy, dirty and smelly. Furthermore, in the water quality analysis, the average value of the TDS parameter was obtained with an average value of 108. TSS obtained an average value of 29.1. The pH got an average value of 8.1. DO got an average score of 7.3. BOD got an average score of 1.4 and COD got an average score of 15.2. From the results of tests carried out at 3 different points, an average value was obtained below the established class 2 water quality standards
Penerapan Adaptasi Teknologi bagi Guru SD Negeri 4 Labuan Tereng untuk Menunjang Proses Pembelajaran
Authors: Baitinniza Baitinniza , Layali Sahratul , Apriliani Munaenah , Hafazah Nurul , Putri Hisa Dewi , Delasita Rabiulandari
Published: January 2024

This research was motivated by the lack of existence and utilization of school infrastructure as well as the lack of motivation, creativity and understanding of teachers in utilizing technology. The purpose of this study is to be able to plan, create and apply a form of technology adaptation tailored to the subjects and school curriculum in the classroom. The research method used is the action research method approach which has the core concept of Kurt Lewin includes 4 components, namely planning, action, observation and reflection. For research planning, it is arranged into 4 stages, namely research preparation, cycle I, cycle II, cycle III.  The techniques used by researchers are interviews, observation, and documentation. Based on the results of the questionnaire that has been disseminated, the percentage of educators who can access technology is 87% more than those who cannot access technology as much as 13%. Thus, it is ensured that educators are ready to apply technological adaptation to the classes they attend. The research subjects as data sources in this study are educators or teachers of SDN 4 Labuan Tereng and SMPN Satuatap 1 Lembar consisting of 4 men and 4 women.
Prevalence of urinary tract infection with asymptomatic bacteriuria among gravid females: A Pakistani multicenter cross-sectional study.
Authors: Haleema Yasmin  , Waqar Azim Niaz  , Sadia Zahoor  , Saadia Shamsher  , Masood Shaikh
Published: January 2024

Objective: To determine the prevalence of urinary tract infection with asymptomatic bacteriuria among pregnant females. Study Design: Multi-center, Cross-sectional study. Setting: Department of Obstetrics and Gynecology, Jinnah Postgraduate Medical Center, Karachi, Sheikh Zayed Medical College and Hospital, Rahim Yar Khan, and Hayatabad Medical Complex, Peshawar, Pakistan. Period: January 2023 to June 2023. Material & Methods: A total of 260 pregnant females aged between 18 to 45 years and visiting outpatient department for antenatal check-up were analyzed. Enrolled females were interviewed and demographical and clinical data were noted. All women had their urine analysis done as a routine antenatal test. Urine culture analysis was also done at the same time. Asymptomatic bacteriuria was labeled when urine culture revealed the presence of more than 105 bacteria per milliliter of urine but without showing symptoms of urinary tract infections. Results: In a total of 260 pregnant females, the mean age was 28.6±5.3 years (ranging between 18-45 years). There were 125 (48.1%) females who reported during 3rd trimester of pregnancy. Residential status of 209 (80.4%) females was urban. There were 65 (25.0) females who were illiterate. Family monthly income of 198 (76.2%) females was below 30,000 Pakistani Rupees. Asymptomatic bacteriuria was revealed in 69 (26.5%) pregnant females. The most common urinary bacterial isolates were E. coli and Klebsiella found in 36 (52.2%) and 10 (14.5%) respectively. Conclusion: The prevalence of asymptomatic bacterirua among pregnant females was high (26.5%). The most common urinary isolates found among asymptomatic bacteriuria cases were E.coli.
Assessment of malocclusion and patients' need for orthodontic treatment.
Authors: Ariffullah Khan  , Aasim Masood  , Muhammad Salman Khan  , Syed Fahad Ali Shah  , Muhammad Harris Zia  , Kanwal Safeer
Published: January 2024

Objective: To document the frequency of various classes of Angle’s malocclusion and its treatment need among children of both gender between 13-17 years age attending government high schools in Peshawar District. Study Design: Cross sectional study. Setting: Khyber Medical University Institute of Dentistry. Period: Jan 2020 to Nov 2021. Material & Methods: 900 patients of both genders between the ages of 13 and 17 were used in the current investigation. A performa was used to record malocclusions e.g. Angle's classification, overjet, overbite, open bite and cross bite. For various malocclusions, the Dental Health Component (DHC) of the Index of Orthodontic Treatment Need (IOTN) index was reported. Results: We looked at 900 students between the ages of 13 and 17 whose guardians had signed a written consent form. Among the 900 students who were examined, 60% (540) were males, and 40% (360) were females. 175 individuals had normal dental health, 420 had class 1 malocclusions, 265 had class 2s, and 40 had class 3s. Overjet was excessive in 210 cases and reduced in 53. Overbite was excessive in 201 cases and reduced in 34. In 185, there was an open bite. The difference was significant (P < 0.05). In 489 cases, DHC grade I and II, 310 cases, grade III, and 101 cases, grade IV, and grade V. The difference was significant (P< 0.05). Conclusion: The most frequent malocclusion is class 1. DHC grades I and II were more frequently observed in patients. Malocclusion can be identified using the Dental Health Components (DHC) of the Index of Orthodontic Treatment Need (IOTN).
Evaluation of anxiety and hemodynamic changes in surgical removal of lower third molar under local anesthesia.
Authors: Faryal  , Asna Khalid  , Muhammad Ahmed Khan  , Suneel Kumar Punjabi  , Usman Manzoor  , Muhammad Aqeel Aslam  , Salman Shams
Published: January 2024

Objective: To determine the anxiety and hemodynamic changes in surgical removal of lower third molar under local anesthesia. Study Design: Comparative Cross-sectional study. Setting: Department of Oral and Maxillofacial Surgery, Institute of Dentistry of Liaquat University of Medical Health Sciences, Jamshoro. Period: January 2021 to December 2021. Material & Methods: Three hundred and fourteen patients were selected by non-probability convenience sampling technique. Patient having age between 18 to 50 years with either gender presented with third molar surgical extraction, first experience of tooth extraction and partial bony impaction were included in study. The demographic and clinical parameters like age, gender, level of anxiety and hemodynamic changes were identified. Hemodynamic parameters were recorded on before starting the surgical procedure (T1), after 5 minutes of injecting local anesthesia (T2) and after completion of surgery (T3). Results: Out of 314 patients, male patients were 156 (49.7%) and female patients were 158 (50.3%) with mean age of 31.0 ± 9.2 (18-50). In third molar extraction significant difference was observed for hemodynamic parameters at T1, T2 and T3 intervals. Conclusion: Surgical removal of lower third molar under local anesthesia significantly increases the anxiety, blood pressure and heart rate after injecting local anesthesia.
Comparison of diagnostic accuracy of conventional ultrasonography for characterization of axillary lymph nodes with histological findings.
Authors: Sana Mehmood  , Shamoona Rashid  , Humayun Suqrat
Published: January 2024

Objective: To determine the diagnostic accuracy of conventional ultrasonography for characterization of axillary lymph nodes. Study Design: Cross-sectional study. Setting: Department of Radiology, Aziz Fatima Medical and Dental Hospital, Faisalabad. Period: 1st of October 2022 to 31st of March 2023. Material & Methods: A total number of 145 female patients above the age of 18 years who reported with mastalgia and diagnosed clinically with the presence of suspicious axillary lymph nodes were included in the study. The conventional ultrasonic evaluation index was used for characterization. The ultrasonological results of characterization of axillary lymph nodes were compared with histopathological results where results of histopathology were taken as gold standard. Results: The Mean±SD of age in this study was 44.15±8.42 years with an age range of 29-62 years. The Mean±SD of duration of complaints was 10.17±5.60 months. USG diagnosed 89 (61.37%) patients while histopathology diagnosed 92 (63.44%) patients with metastasis of ALN. USG showed sensitivity of 86.957%, specificity 83.019%, diagnostic accuracy 86%, PPV 89.888% and NPV 78.571% in diagnosis of metastasis of axillary lymph nodes (p < 0.000). Conclusion: Conventional USG is a commonly available and affordable diagnostic tool which is useful with a good accuracy for characterization of axillary lymph nodes and detecting the metastasis.
Juventudes e Educação: a escola como território juvenil
Authors: Oliveira Victor Hugo Nedel , Lacerda Miriam Pires Corrêa de , Groppo Luis Antônio , Castrogiovanni Antonio Carlos , Carrera Ana Daniele Mendes , Silva André Luiz dos Santos , Mariro Blue , Silveira Bruno Xavier , Basso Cheila , Guedes Claudiney Saraiva , Vieira Dioneia Maria Samua , Bortone Douglas Franco , Eggert Edla , Silva Junior Gilberto Miranda da , Belchior Izac de Sousa , Toledo Joilson de Souza , Santos José Ricardo Marques dos , DallAgnese Júlia , Franz Juliana Cristina , Hundertmarck Katiele , Greque Junior Leonardo da Silva , Reis Lílian Perdigão Caixêta , Souza Lindomar Pereira de , Bassalo Lucélia de Moraes Braga , Bernardi Lucí dos Santos , Brito Júnior Luiz Carlos Gomes de , Loreto Maria das Dores Saraiva de , Bing Marília Dal Moro , Mano Natália Yukari , Barroso Priscila Farfan , Anjos Raquel Viana dos , Rieth Ricardo Willy , Lima Stalin Braga de , Basso Susana Schwartz , Anjos Thaiana Machado dos , Sousa Wanderson William Fidalgo de
Published: January 2024

Os capítulos do presente livro fazem deste tema, a escola como território ressignificado pelas juventudes, como mote para falar não apenas dele propriamente dito, mas de vários outros temas de grande relevância. Estes temas, nunca abandonando as juventudes e o espaço escolar, trazem os próprios interesses e experiências das autoras e dos autores, além de colocar este livro em diálogo com a vanguarda do que tem se pesquisado em juventudes na atualidade (Luis Antônio Groppo).

Nesta viagem cujo roteiro chama-se Juventudes e Educação: a escola como território juvenil, organizado pelos professores Victor Hugo Nedel Oliveira e Miriam Pires Corrêa de Lacerda traz, sob lentes de renomados pesquisadores que nos provocam a pensar sobre a importância em escutarmos os jovens (Antônio Carlos Castrogiovanni).
Understanding Experimental Facts for the Transformation of Perezone into α- and β-pipitzols
Authors: Soto Suárez Fatima Montserrat , Cuevas González Bravo Gabriel Eduardo , Murillo Herrera Luis Mauricio , Hernández-Huerta Eduardo , Ortiz Reynoso Mariana , Ramírez Gualito Karla , Quijano Quiñones Ramiro Felipe
Published: January 2024

Under thermal conditions perezone, a sesquiterpene quinone, forms an equimolar amount of a- and β-pipitzol through an intermolecular cycloaddition reaction. Computational calculations at M06-2x/6-311++G(2d,2p) level of theory of the transition states and the associated reaction paths allow justifying the experimental observations. Only exo adducts are observed experimentally, which is in line with the calculated energy difference of 6.5 kcal/mol between the transition states associated with the endo and exo adducts. Activation free energy was accurately predicted, those the uncatalyzed thermal process of cycloaddition requires 37.0 kcal/mol. The study of the potential energy surface allows to establish the existence of folded conformers of perezone in the potential energy surface.
 
Resumen. En condiciones térmicas la perezona, una quinona sesquiterpénica, forma, cantidades equimolares de a- y β-pipitzoles a través de una reacción de cicloadición intramolecular. A nivel M06-2x/6-311++G(2d,2p) el cálculo de los estados de transición y de las trayectorias de reacción asociadas permiten justificar los resultados observados. Desde el punto de vista experimental sólo se forman los aductos exo y no los endo pues los estados de transición relacionados muestran una diferencia energética de 6.5 kcal/mol. La energía de activación calculada para el procedo desprovisto de catálisis es de 37.0 kcal/mol. El estudio de la superficie de energía potencial permite establecer la existencia de confórmeros plegados de la perezona.
Synthesis, in vitro Antitrichomonal Activity, and Docking Study of N-[(4-substituted phenyl)-1,3-thiazol-2-yl]-4-substituted Benzenesulfonamides
Authors: M. Carballo Rubén , Peniche-Pavía Héctor A. , Quijano-Quiñones Ramiro , Cáceres-Castillo David , Mirón-López Gumersindo , Graniel-Sabido Manlio , Reyes-Cuapio Andrea , Moo-Puc Rosa E. , Valencia-Chan Lía , Mena-Rejón Gonzalo Joaquín
Published: January 2024

Infection by Trichomonas vaginalis has a high incidence/prevalence worldwide. It has been associated with a predisposition to cervical neoplasia or prostate cancer and an increased risk of acquisition of human papillomavirus (HPV) and human immunodeficiency virus (HIV). Besides, resistance to the drugs used for trichomoniasis treatment has increased in the last 30 years. Herein, thirteen phenylthiazolylbenzene sulfonamides were synthesized and evaluated for their in vitro activity against Trichomonas vaginalis. Among them, four derivatives showed higher anti-trichomonal activity than metronidazole (IC50 = 0.93 µM), while their cytotoxicity levels were not significant. These compounds were subject to molecular docking studies using Trichomonas vaginalis ferredoxin as target. The results revealed that the orientation of the nitro group of the active derivatives is toward [2Fe-2S], the cluster responsible for high reactive oxygen species generation. Finally, it was evident that the presence of a nitro group in the structure of the synthesized phenylthiazolylbenzene sulfonamides is essential for their trichomonicidal activity.
 
Resumen. A nivel mundial la infección por Trichomonas vaginalis tiene una alta incidencia/prevalencia y se ha asociado con una predisposición a padecer neoplasia cervical o cáncer de próstata, así como a generar un mayor riesgo de adquirir el virus del papiloma humano (VPH) y el virus de la inmunodeficiencia humana (VIH). Además, en los últimos 30 años, la resistencia a los fármacos utilizados para el tratamiento de la tricomoniasis ha aumentado. En el presente trabajo, trece sulfonamidas de feniltiazolilbenceno fueron sintetizadas y evaluadas in vitro contra Trichomonas vaginalis. Cuatro de ellas exhibieron una actividad anti-tricomonas mayor que el metronidazol (CI50 = 0.93 µM), a la vez que citotoxicidad no significativa. Por tal motivo, estos compuestos fueron sometidos a estudios de acoplamiento molecular utilizando como diana a la ferredoxina de T. vaginalis. Los resultados revelaron que la orientación del grupo nitro de los derivados activos está dirigida hacia el grupo [2Fe-2S], responsable de la generación de especies de oxígeno altamente reactivas. Finalmente, se evidenció que la presencia de al menos un grupo nitro en la estructura de las sulfonamidas de feniltiazolilbenceno sintetizadas es esencial para su actividad tricomonicida.
Sun’s six conjectures on Apéry-like sums involving ordinary harmonic numbers
Authors:   Euler Circle, Palo Alto, CA 94306, USA., Chavan Parth , Chavan Sarth ,   Euler Circle, Palo Alto, CA 94306, USA.
Published: January 2024

The main goal of this brief article is to provide an elementary proof of Sun’s six conjectures on Apéry-like sums involving ordinary harmonic numbers.
KG-Sombor index of Kragujevac trees
Authors:   Faculty of Science, University of Kragujevac, 34000 Kragujevac, Serbia., Gutman Ivan , Redžepović Izudin ,   Faculty of Science, University of Kragujevac, 34000 Kragujevac, Serbia., Kulli Veerabhadrappa R. ,   Department of Mathematics, Gulbarga University, Kalaburgi 585 106, India.
Published: January 2024

The paper is concerned with the KG-Sombor index (\(KG\)), a recently introduced vertex-and-edge-degree-based version of the Sombor index, applied to Kragujevac trees (\(Kg\)). A general combinatorial expression for \(KG(Kg)\) is established. The species with minimum and maximum \(KG(Kg)\)-values are determined.
Efficacy of Modified Toggle Splint with Nylon Suture for ‎‎Stabilization of Coxofemoral ‎Luxation in Dogs
Authors: Q AL-Samarrai Mina , A AL-Timmemi Hameed
Published: January 2024

Coxofemoral luxation is a common orthopedic lesion in dogs. This study aimed to evaluate ‎the effectiveness of a modified toggle splint with nylon suture as a prosthetic teres ligament ‎for reducing and fixing coxofemoral luxation in dogs. Five adult mongrel dogs weighing ‎‎15±2 kg were used in this experimental study. The toggle splint was fabricated from a ‎Steinmann pin (1cm length, 2mm diameter) by drilling 0.5 mm hole in the center. ‎Stabilization of coxofemoral joint was performed by a modified Toggle splint technique. A ‎tunnel, from the major trochanter through the fovea capitis to the acetabulum, was ‎performed in which the toggle splint was passed through, and nylon suture was used for ‎fixation. Dogs were scored for lameness severity at 0-, 14-and 42-day post-operation using a ‎numerical rating scale (NRS) with 5 levels, and reductions were assessed radiographically ‎at three-time points the day of operation, day 28th, and day 42nd. The results showed that the ‎treatment splint was effective in achieving good reduction and fixation in four out of five ‎‎(80%) dogs at all time points. Reluxation was observed only in one dog (20%) up to week 6 ‎post-operation. The mean lameness score on day 14 (2.0±0.87) and 42 (0.60±0.60) were ‎significantly lower (P<0.001) compared to day 0. These results indicate that the modified ‎toggle splint with nylon suture is a promising treatment option for canine coxofemoral ‎luxation.
Preparation and Characterization of Bovine Small Intestine Submucosa (SIS) ‎Hydrogel
Authors: K Hummadi Saddam , HR Al-Falahi Nadia
Published: January 2024

The aim of this study was to prepare and characterize a small intestine submucosa (SIS) hydrogel as ‎a bio-scaffold. In this study, SIS from five calves, aged 8-12 months and weighing 250-300 kg, was ‎obtained from a slaughterhouse immediately after slaughtering. The SIS was then decellularized, ‎powdered, and subsequently transformed into a hydrogel. This transformation was achieved by ‎dissolving the decellularized SIS powder in phosphate-buffered saline (PBS) at a concentration of ‎‎50% w/v, and allowing it to form a hydrogel over a 12-hour period at 37 °C. Characterization of the ‎SIS hydrogel was conducted using various techniques. Fourier Transform Infrared Spectroscopy ‎‎(FTIR) was employed to identify the chemical structure of the hydrogel, revealing three primary peaks ‎at 1639 cm-1, 1571 cm-1, and 1338 cm-1, corresponding to amide I, II, and III bands, respectively. ‎Additionally, a broad signal at 3440 cm-1 was observed, indicative of the hydroxyproline side chain. ‎The hydrogel's swelling capacity was evaluated, showing an expansion of 437% after a 12-hour ‎immersion in PBS at a pH of 7.4. Scanning Electron Microscopy (SEM) analysis of the lyophilized ‎hydrogel revealed a highly porous and interconnected architecture, resembling a honeycomb ‎structure. Moreover, the hydrogel's antibacterial efficacy was assessed against Staphylococcus ‎aureus using an agar diffusion test, which demonstrated a zone of inhibition measuring 16.11 mm. ‎The combined chemical, morphological, and antibacterial properties of the SIS hydrogel developed ‎in this study suggest its potential as a promising bio-scaffold for inducing tissue regeneration and ‎restoring tissue function‎.
Investigating the Potential Hepatoprotective Effect of Quercetin in Male Rats ‎Following Acute Exposure to Cyclophosphamide
Authors: M. Khalaf Mustafa , A Salih Rana
Published: January 2024

This study aimed to assess the hepatoprotective efficacy of quercetin against ‎hepatotoxicity ‎induced by cyclophosphamide in a rat model. A total of 28 male ‎Wister albino rats (Rattus ‎norvegicus), with body ‎weights ranging from 195.5 to ‎‎198.2 g and approximately three months ‎of age, were randomized into four different ‎groups: the untreated Control group ‎received no interventions; the CYP group was treated with an intraperitoneal ‎injection of ‎cyclophosphamide at a dose of 200 mg/BW; the Qt group received an ‎‎oral administration of quercetin at 100 mg/kg BW daily for ten days; and the combined (Qt+CYP) group received quercetin orally for ten days, followed by a ‎cyclophosphamide ‎injection on the tenth day. Various biochemical markers, ‎including alanine aminotransferase ‎‎(ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and liver glutathione ‎‎(GSH), and malondialdehyde ‎‎(MDA), were analyzed, in addition to body weight and ‎prothrombin time. The ‎Untreated Control group exhibited baseline levels for all assessed ‎markers. In ‎contrast, the CYP group showed elevated levels of ALT, AST, ‎‎ALP, and MDA, coupled with a decrease in GSH. Notably, the Qt+CYP ‎group ‎demonstrated a statistically significant reduction (P‎‎<0.05) in ALT, AST, ALP, ‎and MDA levels, ‎as well as an increase in GSH and prothrombin time, when ‎compared to the CYP group. No significant differences in body ‎weight were observed across all groups ‎‎(P‎‎<0.05). The results of the study indicate that quercetin has the potential to be used as a ‎‎hepatoprotective agent, protecting liver tissues from the cytotoxic effects of cyclophosphamide.
Comparative analysis of tick burden, diversity, and distribution in intensively managed wildlife estates with and without prescribed burning
Authors: Maambo Bhagoos  , Tasha Siame  , Musso Munyeme  , Enala Tembo Mwase
Published: January 2024

The connection between ticks and zoonotic diseases in Zambia remains unclear due to limited data on tick distribution in private game reserves. This study examines tick control in three ex-situ game reserves across different agro-ecological regions, Lanagani game ranch in the Chibombo district, Chaminuka game ranch in the Lusaka district, and Choma game ranch in the Choma district. The current study evaluated the burden and diversity of ticks across three different management systems concerning the use of fire as a tick control and management tool. A descriptive cross-sectional study collected 267 ticks from 36 transects across three game ranches in Central, Lusaka, and Southern provinces. These ticks were morphologically identified using the existing taxonomic keys and Olympus DF Plapo 1×4 SN5G 08128 stereomicroscope at the University of Zambia, School of Veterinary Medicine, parasitology laboratory. The Analysis of Variance (ANOVA) was used to compare means between categories and correlation coefficient to determine the strength of the relationship. The collected species included 11 Rhipicephalus species, n=6, (Rhipicephalus appendiculatus, Rhipicephalus evertsi, Rhipicephalus microplus, Rhipicephalus decoloratus, Rhipicephalus sanguineus, Rhipicephalus pulcherus, Rhipicephalus zambeziensis); Amblyomma species n=2, (Amblyomma variagatum, Amblyomma poposum), and Hyalomma species n=2 (Hyalomma Rufipes and Hyalomma truncatum). The most common species were R. evertsi (19.4 %), Amblyomma variagatum 14%, Hyalomma truncatum 11%. Significantly higher (p < 0.05) species diversity and burden were observed in the no-burn management system, whilst no significant differences (p > 0.05) were observed between late and early burning systems. These findings have unveiled, for the first time in Zambia, that employing fire as a management tool substantially reduces both tick diversity and burden in enclosed ex-situ conservancy areas. Regular prescribed burning, regardless of the burning regime, was found to remarkably reduce tick populations in game ranches, particularly in the early burning management system. These findings hold promising implications for ecological public health. Considering this, fire as a management tool effectively reduces tick diversity and burden in closed ex-situ conservancy areas. These findings have far-reaching policy implications when it comes to tick control systems that a government may wish to implement.
A review on role of herbal medicine in daily life
Authors: Priyanka D. Dhandge  , Swati P Deshmukh
Published: January 2024

Writing a review on the use of medicinal shops involves assessing their effectiveness and safety in treating colorful health conditions. To exhaustively assess their remedial value, it's pivotal to consider scientific substantiation, traditional knowledge, and implicit side effects. This review aims to epitomize and dissect the scientific exploration on the medical benefits of shops. These shops are constantly employed as food complements, seasonings, traditional drink constituents, and colorful skin related operations. By examining the being literature, this review provides an overview of the implicit remedial parcels associated with these shops. The shops presented in the exploration are zinger, black cumin seed, Isabgol etc. The number of cases seeking alternate and herbal remedy is growing exponentially. Herbal drugs are the conflation of remedial gests of generations of rehearsing croakers of indigenous systems of drug for over hundreds of times. Herbal drugs are now in great demand in the developing world for primary health care not because they're affordable but also for better artistic adequacy, better comity with the mortal body and minimum side goods.
Formulation and evaluation of bilastine loaded solid Self-Nano Emulsifying Drug Delivery System (s-SNEDDS) for oral administration: In-vitro characterization
Authors: Imdad H. Mukeri  , M. Sunitha Reddy
Published: January 2024

The aim of this study was to prepare an oral administrable SNEDDS for poorly water soluble drugs Bilastine. To choose the SNEDDS excipients, a ternary phase diagram and solubility assessment were conducted. A components of oil (capmul PG-NF) surfactant (Tween 40) and co-surfactant (Capryol 90) were used as the excipients. The optimized formulation was characterized for In-vitro analysis. The prepared S-SNEDDs exhibited good flow characteristics and Particle size (148.5dnm), zeta potential (−28.6), PDI (0.242), drug loading efficiency, % CDR of the optimized S-SNEDDs [TP3PG1 (2:8)] was found to be 103.61 ±0.678, 98.65% respectively. The formulation was stable over a 3-month storage period at 25 ◦C and 4 ◦C in terms of particle size, physical appearance, and drug loading. Overall, a range of lipid based SNEDDS liquid, solid formulations were successfully developed and seem to be a promising alternative to improving the solubility of poorly water-soluble drugs and evaluating In-vitro characterizations.
A new method for improved topical drug delivery, Emulgel
Authors: Rakesh R.Gore  , Aditi A Kasture  , Manjunath G. Mukkane  , Bhimaskankar K.Bhui  , Sandip V.Jadhav  , Rani M.Mhetre
Published: January 2024

Emulgel is used to treat injuries and diseases such as arthritis, headaches, muscle aches, backaches, and those brought on by colds. Patient compliance with topical formulations is crucial in the treatment of chronic dermatosis such psoriasis, acne, and fungal infections. Emulgel, a more recent NDDS technology used topically, combines the characteristics of an emulsion with a gel to provide a dual control release. Emulgels have emerged as one of the most exciting topical delivery methods because of their dual release control mechanism, which combines a gel with an emulsion. Gels have many benefits, but one significant drawback is that hydrophobic medication delivery is hampered. An emulsion-based approach is being developed to circumvent this limitation and enable even a hydrophobic medicinal component to take use of the unique properties of gels. Emulgel is the name given to the dosage form created by combining gel with emulsion. Emulgels can be added to analgesics and antifungal medications. In several aspects, these emulgels are superior to both cutting-edge vesicular systems and traditional systems.
Dental sleep medicine: Bridging gaps in sleep-related breathing disorder care: A short review
Authors: Sandra Prasad Felix Cherukodath  , Brinda Suhas Godhi  , Shalini Yurembam  , Seema Deshmukh  , Sohini Saha
Published: January 2024

Sleep-related disorders, with a particular emphasis on obstructive sleep apnoea (OSA), exert a substantial impact on the overall well-being of affected individuals. Based on collaborative efforts across diverse disciplines, dental sleep medicine, orchestrated by dentists, assume a crucial role in the identification of these disorders through routine examinations, where they keenly discern indicative cues. The incorporation of dentistry into the realm of sleep medicine paves the way for fresh avenues in the diagnosis, management, and treatment of sleep-related breathing disorders. This multidisciplinary approach not only augments the quality of sleep but also bolsters overall well-being. As research continues to advance, dental sleep medicine is poised to assume a pivotal role in catering to the diverse needs of individuals grappling with these disorders.
An activity of flavonoid derived compounds from Medinilla speciosa as anti-hyperpigmentation against tyrosinase proteins with in silico methods
Authors: Elshinta Riantica  , Awik Puji Dyah Nurhayati  , Noor Nailis Sa’adah
Published: January 2024

Parijoto (Medinilla speciosa), a typical plant from Indonesia, contains flavonoid compounds as antioxidants. It is able to depigment skin by inhibiting tyrosinase activity during melanogenesis, or melanin formation. Melanogenesis occurs through UV light exposure; it stimulates ROS production and triggers the formation of free radicals and melanogenesis. If not prevented, it will have negative impacts on health. Currently, there is no further research regarding the existence of flavonoid compound derivatives found in parijoto fruit. The aim of this research is to initially identify potential flavonoid derivative compounds as tyrosinase inhibitors using in silico methods. The results can be used as an initial reference for making products based on natural ingredients with minimal side effects. This research uses a bioinformatics approach with the molecular docking method of ligands towards proteins. The stages in this research include: downloading and preparing receptors and ligands; docking with Autodock Vina; visualization of results with Biovia Discovery Studio; data analysis; and discussion. The analysis is carried out by looking at the affinity energy values and complex conformation between the receptor-ligand. The results show flavonoid derivative compounds have the potential to act as tyrosinase inhibitors, as proven by compounds interactions with the active site of tyrosinase to produce the amino acid residues phenylalanine, proline, asparagine, arginine, and histamine. Produce respective affinity energy values, namely -8.9; -7.7; -7.6; -7.5; -7.5; and 7.4 kcal/mol for chalcone, catechin, flavonol, flavanol, flavone, and flavonone compounds. Meanwhile, the comparison compound used is kojic acid, with an affinity energy of -5.5 kcal/mol.
Spatial analysis in epidemiological studies of dengue: A systematic review and meta-analysis
Authors: Thi-Hien Cao  , Thi-Bich-Thuy Luong
Published: January 2024

Background: Dengue is a serious tropical disease caused by the mosquito-borne dengue virus (DENV). Over the last 50 years, the incidence of dengue fever (DF) and dengue fever and dengue hemorrhagic fever (DHF) worldwide has increased by 50-fold and 2.5 billion people currently live in dengue-endemic regions. This study reports a systematic review and meta-analysis of different types of applications offered by spatial analysis in epidemiological studies of dengue. Materials and methods: A comprehensive literature search of Web of Science, SCOPUS, Google Scholar, and PubMed were conducted up to December 2023. A total of three sub-sections, namely spatial analysis of points, spatial analysis of area data, and software programs used for spatial analysis of dengue cases, will be presented in this review. Results: It was found that spatial analysis can effectively support the study of dengue fever and dengue hemorrhagic fever such as to investigate spatial patterns, hotspot, spatial clustering, the spread, transmission of dengue fever and dengue hemorrhagic fever and it’s affecting factors. Conclusion: applications of spatial analysis can provide important information and contribute to development of effective measurements to control and prevent the dengue fever and dengue hemorrhagic fever transmission. Finding in this study provide an insight into how to use different techniques in the study of dengue fever and dengue hemorrhagic fever.