bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Figures 1-5, Tables 1-3 from Hypoxia-Inducible Factor-2α Activation Promotes Colorectal Cancer Progression by Dysregulating Iron Homeostasis
Authors: Xue Xiang , Taylor Matthew , Anderson Erik , Hao Cathy , Qu Aijuan , Greenson Joel K. , Zimmermann Ellen M. , Gonzalez Frank J. , Shah Yatrik M.
Published: April 2023

PDF file - 417K
Supplementary Tables 1-4, Figure 1 from Immunotype and Immunohistologic Characteristics of Tumor-Infiltrating Immune Cells Are Associated with Clinical Outcome in Metastatic Melanoma
Authors: Erdag Gulsun , Schaefer Jochen T. , Smolkin Mark E. , Deacon Donna H. , Shea Sofia M. , Dengel Lynn T. , Patterson James W. , Slingluff Craig L.
Published: April 2023

PDF file - 118K
Supplementary Table 1 from Genetically Mediated Nf1 Loss in Mice Promotes Diverse Radiation-Induced Tumors Modeling Second Malignant Neoplasms
Authors: Choi Grace , Huang Brian , Pinarbasi Emile , Braunstein Steve E. , Horvai Andrew E. , Kogan Scott , Bhatia Smita , Faddegon Bruce , Nakamura Jean L.
Published: April 2023

PDF file - 50K, Tumor Histologies generated from the AI model
Supplementary Figure 2 from Genetically Mediated Nf1 Loss in Mice Promotes Diverse Radiation-Induced Tumors Modeling Second Malignant Neoplasms
Authors: Choi Grace , Huang Brian , Pinarbasi Emile , Braunstein Steve E. , Horvai Andrew E. , Kogan Scott , Bhatia Smita , Faddegon Bruce , Nakamura Jean L.
Published: April 2023

PDF file - 329K, Hematologic Endpoints
Supplementary Figure 4 from HMGA2 Is a Driver of Tumor Metastasis
Authors: Morishita Asahiro , Zaidi M. Raza , Mitoro Akira , Sankarasharma Devipriya , Szabolcs Matthias , Okada Yasunori , D'Armiento Jeanine , Chada Kiran
Published: April 2023

Supplementary Figure 4 - PDF file 253K, beta-catenin was relocalized to the nucleus at the invasive front of Wnt1-mediated tumor on Hmga2+/+ genotypic backgrounds, but not on the Hmga2-/- genetic background. beta-catenin was detected in the nucleus of the cells at the invasive front consistent with the HMGA2 expressed cells in the Wnt1-mediated tumor on the Hmga2+/+ genetic background (arrows). On the other hand, no beta-catenin relocalization was detected in tumor on the Hmga2-/- genotypic backgrounds. Scale bars represent 100microm
Supplementary Figure 2 from CDK Inhibitors Upregulate BH3-Only Proteins to Sensitize Human Myeloma Cells to BH3 Mimetic Therapies
Authors: Chen Shuang , Dai Yun , Pei Xin-Yan , Myers Jennifer , Wang Li , Kramer Lora B. , Garnett Mandy , Schwartz Daniella M. , Su Florence , Simmons Gary L. , Richey Justin D. , Larsen Dustin G. , Dent Paul , Orlowski Robert Z. , Grant Steven
Published: April 2023

PDF file - 140K, FP/obatoclax down-regulates Bcl-xL, but not Bcl-2, which plays a partial role in this regimen
Supplementary Figure 1 from CDK Inhibitors Upregulate BH3-Only Proteins to Sensitize Human Myeloma Cells to BH3 Mimetic Therapies
Authors: Chen Shuang , Dai Yun , Pei Xin-Yan , Myers Jennifer , Wang Li , Kramer Lora B. , Garnett Mandy , Schwartz Daniella M. , Su Florence , Simmons Gary L. , Richey Justin D. , Larsen Dustin G. , Dent Paul , Orlowski Robert Z. , Grant Steven
Published: April 2023

PDF file - 104K, FP/obatoclax induces dose-dependent mitochondrial injury and cell death in MM cells, accompanied by down-regulation of Mcl-1 protein and mRNA
Supplementary Figure 6 from RNF8 Regulates Assembly of RAD51 at DNA Double-Strand Breaks in the Absence of BRCA1 and 53BP1
Authors: Nakada Shinichiro , Yonamine Rikako Miyamoto , Matsuo Koichi
Published: April 2023

PDF file - 155K, RNF8 suppresses RAD51 assembly in BRCA1/53BP1-depleted 293T cells
Supplementary Figure 4 from RNF8 Regulates Assembly of RAD51 at DNA Double-Strand Breaks in the Absence of BRCA1 and 53BP1
Authors: Nakada Shinichiro , Yonamine Rikako Miyamoto , Matsuo Koichi
Published: April 2023

PDF file - 217K, Cell cycle analysis
Supplementary Table 1 from Gliomagenesis Arising from Pten- and Ink4a/Arf-Deficient Neural Progenitor Cells Is Mediated by the p53-Fbxw7/Cdc4 Pathway, Which Controls c-Myc
Authors: Kim Hong Sug , Woolard Kevin , Lai Chen , Bauer Peter O. , Maric Dragan , Song Hua , Li Aiguo , Kotliarova Svetlana , Zhang Wei , Fine Howard A.
Published: April 2023

PDF file, 322K, Pten-/-Ink4a/Arf-/-mNSCs induced gliomas. Intracranial Pten-/-Ink4a/Arf-/-mNSCs injected mice generated different tumor phenotypes with different survivals. II: WHO Grade II astrocytoma; III: WHO Grade III astrocytoma; IV: WHO Grade IV astrocytoma (GBM).
Supplementary Figure 4 from Gliomagenesis Arising from Pten- and Ink4a/Arf-Deficient Neural Progenitor Cells Is Mediated by the p53-Fbxw7/Cdc4 Pathway, Which Controls c-Myc
Authors: Kim Hong Sug , Woolard Kevin , Lai Chen , Bauer Peter O. , Maric Dragan , Song Hua , Li Aiguo , Kotliarova Svetlana , Zhang Wei , Fine Howard A.
Published: April 2023

PDF file, 111K, Substrates of Fbxw7
Supplementary Figure 7 from Transition from Colitis to Cancer: High Wnt Activity Sustains the Tumor-Initiating Potential of Colon Cancer Stem Cell Precursors
Authors: Shenoy Anitha K. , Fisher Robert C. , Butterworth Elizabeth A. , Pi Liya , Chang Lung-Ji , Appelman Henry D. , Chang Myron , Scott Edward W. , Huang Emina H.
Published: April 2023

PDF file - 867K, Beta-catenin knockdown
Supplementary Figure 2 from Gliomagenesis Arising from Pten- and Ink4a/Arf-Deficient Neural Progenitor Cells Is Mediated by the p53-Fbxw7/Cdc4 Pathway, Which Controls c-Myc
Authors: Kim Hong Sug , Woolard Kevin , Lai Chen , Bauer Peter O. , Maric Dragan , Song Hua , Li Aiguo , Kotliarova Svetlana , Zhang Wei , Fine Howard A.
Published: April 2023

PDF file, 323K, Secondary gliomas derived from GSCs.
Supplementary Figure 4 from Transition from Colitis to Cancer: High Wnt Activity Sustains the Tumor-Initiating Potential of Colon Cancer Stem Cell Precursors
Authors: Shenoy Anitha K. , Fisher Robert C. , Butterworth Elizabeth A. , Pi Liya , Chang Lung-Ji , Appelman Henry D. , Chang Myron , Scott Edward W. , Huang Emina H.
Published: April 2023

PDF file - 2MB, Wnt activity in ALDH(high)-Wnt(high) and ALDH(high)-Wnt(low) primary tumor xenografts (1o)
Supplementary Figure 3 from Transition from Colitis to Cancer: High Wnt Activity Sustains the Tumor-Initiating Potential of Colon Cancer Stem Cell Precursors
Authors: Shenoy Anitha K. , Fisher Robert C. , Butterworth Elizabeth A. , Pi Liya , Chang Lung-Ji , Appelman Henry D. , Chang Myron , Scott Edward W. , Huang Emina H.
Published: April 2023

PDF file - 66K, Validation of Wnt/beta-catenin reporter in CT-1 pCCSCs
Supplementary Methods from Uncoupling Cancer Mutations Reveals Critical Timing of p53 Loss in Sarcomagenesis
Authors: Young Nathan P. , Crowley Denise , Jacks Tyler
Published: April 2023

Supplementary Methods from Uncoupling Cancer Mutations Reveals Critical Timing of p53 Loss in Sarcomagenesis
Supplementary Figure 2 from Uncoupling Cancer Mutations Reveals Critical Timing of p53 Loss in Sarcomagenesis
Authors: Young Nathan P. , Crowley Denise , Jacks Tyler
Published: April 2023

Supplementary Figure 2 from Uncoupling Cancer Mutations Reveals Critical Timing of p53 Loss in Sarcomagenesis
Supplementary Figure 1 from Uncoupling Cancer Mutations Reveals Critical Timing of p53 Loss in Sarcomagenesis
Authors: Young Nathan P. , Crowley Denise , Jacks Tyler
Published: April 2023

Supplementary Figure 1 from Uncoupling Cancer Mutations Reveals Critical Timing of p53 Loss in Sarcomagenesis
Supplementary Figure 4 from Estrogen Receptor Alpha Mediates Progestin-Induced Mammary Tumor Growth by Interacting with Progesterone Receptors at the Cyclin D1/MYC Promoters
Authors: Giulianelli Sebastián , Vaqué José P. , Soldati Rocío , Wargon Victoria , Vanzulli Silvia I. , Martins Rubén , Zeitlin Eduardo , Molinolo Alfredo A. , Helguero Luisa A. , Lamb Caroline A. , Gutkind J. Silvio , Lanari Claudia
Published: April 2023

PDF file - 3.3MB, Expression of CCND1 and MYC proteins after MPA treatment. T47D cells were starved in 1% chFCS and incubated with MPA (10nM) for different times. Total protein extracts were used in Western blot assays to evaluate the expression of CCND1 and MYC. Erk1/2 was used as loading control. A representative experiment of three (left) is shown together with the quantification of the bands respect to the loading control (right).
Supplementary Figure 3 from Estrogen Receptor Alpha Mediates Progestin-Induced Mammary Tumor Growth by Interacting with Progesterone Receptors at the Cyclin D1/MYC Promoters
Authors: Giulianelli Sebastián , Vaqué José P. , Soldati Rocío , Wargon Victoria , Vanzulli Silvia I. , Martins Rubén , Zeitlin Eduardo , Molinolo Alfredo A. , Helguero Luisa A. , Lamb Caroline A. , Gutkind J. Silvio , Lanari Claudia
Published: April 2023

PDF file - 177K, T47D cells were starved and then treated or not with MPA for 10 min, and processed for immunofluorescence and confocal microscopy using specific antibodies to detect pSer162 PRB and ER� (SP1, A) or pSer294 PR and ER� (M7047, B). Bar: 15�m. Co-localization between nuclear receptors was quantified using the quantitative statistical analysis for nuclear pixel overlap after 10 min of MPA treatment and was estimated using the Pearson's correlation coefficient. (C) Cellular fractionation of T47D cells was controlled by Western blot using anti-tubulin (cytoplasmatic marker, Ab4 from Thermo) or anti-Sp1 (nuclear marker, from Thermo) antibodies. Erk1/2 was used as a loading control. (D) T47D cells were starved and then treated with ICI during 3, 6, 12, 24 and 48 h. ER� (SP1) and PR (Ab7) expression was analyzed by Western blot. Erk1/2 was used as a loading control.
Supplementary Figures 1-6, Methods from The Hypoxia-Associated Factor Switches Cells from HIF-1α- to HIF-2α-Dependent Signaling Promoting Stem Cell Characteristics, Aggressive Tumor Growth and Invasion
Authors: Koh Mei Yee , Lemos Robert , Liu Xiuping , Powis Garth
Published: April 2023

Supplementary Figures 1-6, Methods from The Hypoxia-Associated Factor Switches Cells from HIF-1α- to HIF-2α-Dependent Signaling Promoting Stem Cell Characteristics, Aggressive Tumor Growth and Invasion
Supplementary Figure 5 from Aptamer Identification of Brain Tumor–Initiating Cells
Authors: Kim Youngmi , Wu Qiulian , Hamerlik Petra , Hitomi Masahiro , Sloan Andrew E. , Barnett Gene H. , Weil Robert J. , Leahy Patrick , Hjelmeland Anita B. , Rich Jeremy N.
Published: April 2023

PDF file - 279K, Aptamer A4 high cells have a differential genetic profile associated with downregulation of genes involved in cellular development.
Supplementary Methods, Figure Legends, Figures 1 - 20 from Inhibition of Histone Demethylase JMJD1A Improves Anti-Angiogenic Therapy and Reduces Tumor-Associated Macrophages
Authors: Osawa Tsuyoshi , Tsuchida Rika , Muramatsu Masashi , Shimamura Teppei , Wang Feng , Suehiro Jun-ichi , Kanki Yasuharu , Wada Youichiro , Yuasa Yasuhito , Aburatani Hiroyuki , Miyano Satoru , Minami Takashi , Kodama Tatsuhiko , Shibuya Masabumi
Published: April 2023

PDF file - 1078K
Supplementary Figures from E3 Ubiquitin Ligase RNF126 Promotes Cancer Cell Proliferation by Targeting the Tumor Suppressor p21 for Ubiquitin-Mediated Degradation
Authors: Zhi Xu , Zhao Dong , Wang Zehua , Zhou Zhongmei , Wang Chunyan , Chen Wenlin , Liu Rong , Chen Ceshi
Published: April 2023

Figure S1. RNF126 knockdown decreases cell viability in breast cancer cell lines Figure S2. The expression, subcellular localization, stability, and ubiquitination of RNF126 Figure S3. RNF126 knockdown increases p21 protein levels but does not change p21 mRNA levels in both MDA-MB-231 and PC-3 Figure S4. RNF126 knockdown delays the G1/S cell cycle progression in MDA-MB-231 Figure S5. Stable knockdown of RNF126 in SW527 suppresses cell growth in vitro and in vivo Figure S6. Negative expression correlation between RNF126 and p21 in breast cell lines Table S1: Primer sequences used in this study Table S2: siRNA and shRNA target sequences used in this study
Supplementary Table 1 from A Novel Model for Evaluating Therapies Targeting Human Tumor Vasculature and Human Cancer Stem–like Cells
Authors: Burgos-Ojeda Daniela , McLean Karen , Bai Shoumei , Pulaski Heather , Gong Yusong , Silva Ines , Skorecki Karl , Tzukerman Maty , Buckanovich Ronald J.
Published: April 2023

PDF File - 71K, A List of Antibodies Used.
Supplementary Figure Legends from Erlotinib Resistance in Lung Cancer Cells Mediated by Integrin β1/Src/Akt-Driven Bypass Signaling
Authors: Kanda Rina , Kawahara Akihiko , Watari Kosuke , Murakami Yuichi , Sonoda Kahori , Maeda Masashi , Fujita Hideaki , Kage Masayoshi , Uramoto Hidetaka , Costa Carlota , Kuwano Michihiko , Ono Mayumi
Published: April 2023

PDF - 83K, Supplementary figure legends.
Supplementary Figure 3 from Erlotinib Resistance in Lung Cancer Cells Mediated by Integrin β1/Src/Akt-Driven Bypass Signaling
Authors: Kanda Rina , Kawahara Akihiko , Watari Kosuke , Murakami Yuichi , Sonoda Kahori , Maeda Masashi , Fujita Hideaki , Kage Masayoshi , Uramoto Hidetaka , Costa Carlota , Kuwano Michihiko , Ono Mayumi
Published: April 2023

PDF - 133K, A, PC9 and PC9/ER2-2 cells were exposed to 1 μM erlotinib with or without 0.1 μM dasatinib for 5 hr. B, The sensitivity to dasatinib after exposure for 3 days was determined by proliferation assay.
Supplementary Table 4 from MYC Phosphorylation at Novel Regulatory Regions Suppresses Transforming Activity
Authors: Wasylishen Amanda R. , Chan-Seng-Yue Michelle , Bros Christina , Dingar Dharmendra , Tu William B. , Kalkat Manpreet , Chan Pak-Kei , Mullen Peter J. , Huang Ling , Meyer Natalie , Raught Brian , Boutros Paul C. , Penn Linda Z.
Published: April 2023

XLS file, 160K, GO Analysis of significant genes expression changes.
Supplementary Table 3 from MYC Phosphorylation at Novel Regulatory Regions Suppresses Transforming Activity
Authors: Wasylishen Amanda R. , Chan-Seng-Yue Michelle , Bros Christina , Dingar Dharmendra , Tu William B. , Kalkat Manpreet , Chan Pak-Kei , Mullen Peter J. , Huang Ling , Meyer Natalie , Raught Brian , Boutros Paul C. , Penn Linda Z.
Published: April 2023

XLS file, 319K, Expression array analysis of MCF10A 3D cultures at 4 days.
Supplementary Materials and Methods from MYC Phosphorylation at Novel Regulatory Regions Suppresses Transforming Activity
Authors: Wasylishen Amanda R. , Chan-Seng-Yue Michelle , Bros Christina , Dingar Dharmendra , Tu William B. , Kalkat Manpreet , Chan Pak-Kei , Mullen Peter J. , Huang Ling , Meyer Natalie , Raught Brian , Boutros Paul C. , Penn Linda Z.
Published: April 2023

PDF file, 136K.
Supplementary Movie 2 from Histone Demethylase RBP2 Promotes Lung Tumorigenesis and Cancer Metastasis
Authors: Teng Yu-Ching , Lee Cheng-Feng , Li Ying-Shiuan , Chen Yi-Ren , Hsiao Pei-Wen , Chan Meng-Yu , Lin Feng-Mao , Huang Hsien-Da , Chen Yen-Ting , Jeng Yung-Ming , Hsu Chih-Hung , Yan Qin , Tsai Ming-Daw , Juan Li-Jung
Published: April 2023

Supplementary Movie 2 � MOV file 2208K, cell moving in RBP2 KD1
Supplementary Movie 3 from CIP4 Controls CCL19-Driven Cell Steering and Chemotaxis in Chronic Lymphocytic Leukemia
Authors: Malet-Engra Gema , Viaud Julien , Ysebaert Loïc , Farcé Manon , Lafouresse Fanny , Laurent Guy , Gaits-Iacovoni Frédérique , Scita Giorgio , Dupré Loïc
Published: April 2023

AVI file - 3816K, Time-lapse video-recording of a representative JVM3 cell expressing GFP-CIP4 and migrating over a period of 37 min in a CCL19 gradient (source of CCL19 towards the bottom). The four panels show GFP-CIP4 (green), pseudo-colour scale indicating CIP4 level, transmission and merge.
Supplementary Legends from Histone Demethylase RBP2 Promotes Lung Tumorigenesis and Cancer Metastasis
Authors: Teng Yu-Ching , Lee Cheng-Feng , Li Ying-Shiuan , Chen Yi-Ren , Hsiao Pei-Wen , Chan Meng-Yu , Lin Feng-Mao , Huang Hsien-Da , Chen Yen-Ting , Jeng Yung-Ming , Hsu Chih-Hung , Yan Qin , Tsai Ming-Daw , Juan Li-Jung
Published: April 2023

Supplementary Legends - PDF file 146K, Legend for Supplementary Figures S1-S7, Supplementary Movies S1-S3, and Supplementary Table S1
Supplementary Figures S1-S7 from Histone Demethylase RBP2 Promotes Lung Tumorigenesis and Cancer Metastasis
Authors: Teng Yu-Ching , Lee Cheng-Feng , Li Ying-Shiuan , Chen Yi-Ren , Hsiao Pei-Wen , Chan Meng-Yu , Lin Feng-Mao , Huang Hsien-Da , Chen Yen-Ting , Jeng Yung-Ming , Hsu Chih-Hung , Yan Qin , Tsai Ming-Daw , Juan Li-Jung
Published: April 2023

Supplementary Figures S1-S7 - PDF file 476K, IHC staining of RBP2 protein in normal and cancerous human lung tissues (S1); Knockdown of RBP2 inhibits growth of lung cancer cell A549 (S2); RBP2 knockdown impairs formation of metastatic nodules in lungs of nude mice (S3); Construction of shRNA-resistant HA-tagged RBP2 plasmids (S4); The protein level of p21 is increased in gastric AGS cell line but decreased in lung cancer cells when RBP2 is depleted (S5); RBP2 knockdown effect on G1 cyclin gene expression and the efficiency of p27 depletion (S6); Successful expression of exogenous ITGB1 in RBP2-depeleted H1299 cells does not restore cell growth defect (S7)
Supplementary Figures 1 - 2 from CIP4 Controls CCL19-Driven Cell Steering and Chemotaxis in Chronic Lymphocytic Leukemia
Authors: Malet-Engra Gema , Viaud Julien , Ysebaert Loïc , Farcé Manon , Lafouresse Fanny , Laurent Guy , Gaits-Iacovoni Frédérique , Scita Giorgio , Dupré Loïc
Published: April 2023

PDF file - 93K, CIP4 is dispensable for CCR7 internalization (S1), CIP4 knock-down impairs the polarized morphology of JVM3 cells (S2).
Supplemental Methods from Hbo1 Is a Cyclin E/CDK2 Substrate That Enriches Breast Cancer Stem-like Cells
Authors: Duong MyLinh T. , Akli Said , Macalou Sira , Biernacka Anna , Debeb Bisrat G. , Yi Min , Hunt Kelly K. , Keyomarsi Khandan
Published: April 2023

Detailed methods of all experiments that due to limited space is included in the supplemental section.
Supplementary Figure 2 from Epimorphin Is a Novel Regulator of the Progesterone Receptor Isoform-A
Authors: Bascom Jamie L. , Radisky Derek C. , Koh Eileen , Fata Jimmie E. , Lo Alvin , Mori Hidetoshi , Roosta Neda , Hirai Yohei , Bissell Mina J.
Published: April 2023

PDF file, 845K, Epim overexpression leads to enlargement of organoid cyst and upregulation of Pgr during bud formation.
Supplementary Figure 3 from Targeting Sonic Hedgehog-Associated Medulloblastoma through Inhibition of Aurora and Polo-like Kinases
Authors: Markant Shirley L. , Esparza Lourdes Adriana , Sun Jesse , Barton Kelly L. , McCoig Lisa M. , Grant Gerald A. , Crawford John R. , Levy Michael L. , Northcott Paul A. , Shih David , Remke Marc , Taylor Michael D. , Wechsler-Reya Robert J.
Published: April 2023

PDF file - 2421K, Supplemental Figure 3: Aurk inhibitor cooperates with SHH antagonist and chemotherapeutic agents.
Supplementary Materials Figures and Tables from Myoferlin Is a Key Regulator of EGFR Activity in Breast Cancer
Authors: Turtoi Andrei , Blomme Arnaud , Bellahcène Akeila , Gilles Christine , Hennequière Vincent , Peixoto Paul , Bianchi Elettra , Noel Agnès , De Pauw Edwin , Lifrange Eric , Delvenne Philippe , Castronovo Vincent
Published: April 2023

PDF file, 2894K, Figure S1: Cell migration and invasion analysis following siRNA mediated silencing of myoferlin (MYOF) in MDA-MB231 cells. Figure S2: Myoferlin depletion in MDA-MB468 cells results in sustained EGFR phosphorylation upon EGF stimulation and impedes the EGF-induced cell migration. Figure S3: Analysis of time dependent pEGFR and EGFR expression patterns (48h post transfection with irrelevant siRNA) following EGF stimulation and chemical inhibition of the proteasome with MG132. Figure S4: Cellular adhesion assay on selected extracellular matrix proteins. Figure S5: Modulation of vimentin expression following myoferlin silencing in MDA-MB231 cells. Figure S6: Clathrin (CLH1) colocalizes with myoferlin and pEGFR during EGF mediated receptor activation and shows no modulation at the protein level following myoferlin silencing. Supplemental Tables Table S1: List of up-regulated breast tumor proteins obtained from the analysis of 3 non-tumoral adjacent and 3 tumoral specimens. Table S2: Average values (n=3) indicating the number of unique peptides, sequence coverage and score. Table S3: Glycosylated peptides observed for the proteins displayed in the Table 1.
Supplementary Figure 3 from Disruption of Wild-Type IDH1 Suppresses D-2-Hydroxyglutarate Production in IDH1-Mutated Gliomas
Authors: Jin Genglin , Reitman Zachary J. , Duncan Christopher G. , Spasojevic Ivan , Gooden David M. , Rasheed B. Ahmed , Yang Rui , Lopez Giselle Y. , He Yiping , McLendon Roger E. , Bigner Darell D. , Yan Hai
Published: April 2023

PDF file-101KB, Mutant IDH1 in the absence of wild type IDH1 is not sufficient to efficiently produce D-2HG in HCT116 cells
Supplementary Data from PPARδ Induces Estrogen Receptor-Positive Mammary Neoplasia through an Inflammatory and Metabolic Phenotype Linked to mTOR Activation
Authors: Yuan Hongyan , Lu Jin , Xiao Junfeng , Upadhyay Geeta , Umans Rachel , Kallakury Bhaskar , Yin Yuhzi , Fant Michael E. , Kopelovich Levy , Glazer Robert I.
Published: April 2023

Supplementary Data - PDF file 3276K, Supplementary Figure 1. Characterization of MMTV-PPAR{delta} transgenic mice. Supplementary Figure 2. Metabolomic analysis Supplementary Figure 3. Signaling pathways associated with PPRE-containing genes. activated in MMTV-PPAR{delta} mice treated with GW501516 for 11 weeks. Supplementary Table 1. Antibodies for IHC and western blotting. Supplementary Table 2. List of primers for qRT-PCR analysis. Supplementary Table 3. Gene expression preferentially altered in MMTV-PPAR{delta} mice treated with GW501516 and everolimus. Supplementary Table 4. Gene expression preferentially altered in MMTV-PPARd mice treated with GW501516 for 11 weeks. Supplementary Table 5. Gene expression preferentially altered in MMTV-PPARd mice. Supplementary Table 6. Gene expression preferentially altered in wild-type mice treated with GW501516 for 11 weeks.
Supplementary Figure Legend and Table 1 - 5 from A CD90+ Tumor-Initiating Cell Population with an Aggressive Signature and Metastatic Capacity in Esophageal Cancer
Authors: Tang Kwan Ho , Dai Yong Dong , Tong Man , Chan Yuen Piu , Kwan Pak Shing , Fu Li , Qin Yan Ru , Tsao Sai Wah , Lung Hong Lok , Lung Maria L. , Tong Daniel K. , Law Simon , Chan Kwok Wah , Ma Stephanie , Guan Xin Yuan
Published: April 2023

DOC file - 322K, Supplemental Table 1. Primer sequences for real-time qPCR analyses. Supplemental Table 2. RPKM values of other reported CSC markers in the original 3 pairs of non-tumor (N) and ESCC (T) clinical samples (Patients #16, #18 and #19) used for RNA-Seq profiling. Supplemental Table 3. Cancer stem cell marker expression (CD90, CD44 and p75NTR / CD271) in a panel of ESCC cell lines. Supplemental Table 4. Clinicopathological correlation of CD44 and p75NTR / CD271 expression in ESCC. Supplemental Table 5. List of deregulated genes in CD90+ vs. CD90- cells in ESCC cells KYSE140 (cut off ≥ 3 folds).
Supplementary Video 2 from Senescent Fibroblasts in Melanoma Initiation and Progression: An Integrated Theoretical, Experimental, and Clinical Approach
Authors: Kim Eunjung , Rebecca Vito , Fedorenko Inna V. , Messina Jane L. , Mathew Rahel , Maria-Engler Silvya S. , Basanta David , Smalley Keiran S.M. , Anderson Alexander R.A.
Published: April 2023

MOV file - 5102K, This video shows the spatio-temporal evolution of vSkin that produced Figure 4A (wound healing).
Supplementary Video 9 from Endogenous Two-Photon Fluorescence Imaging Elucidates Metabolic Changes Related to Enhanced Glycolysis and Glutamine Consumption in Precancerous Epithelial Tissues
Authors: Varone Antonio , Xylas Joanna , Quinn Kyle P. , Pouli Dimitra , Sridharan Gautham , McLaughlin-Drubin Margaret E. , Alonzo Carlo , Lee Kyongbum , Münger Karl , Georgakoudi Irene
Published: April 2023

AVI file - 1191KB, Representative endogenous TPEF OPTICAL STACK E6 EETE.
Supplementary Methods from Tumor Hypoxia Does Not Drive Differentiation of Tumor-Associated Macrophages but Rather Fine-Tunes the M2-like Macrophage Population
Authors: Laoui Damya , Van Overmeire Eva , Di Conza Giusy , Aldeni Chiara , Keirsse Jiri , Morias Yannick , Movahedi Kiavash , Houbracken Isabelle , Schouppe Elio , Elkrim Yvon , Karroum Oussama , Jordan Bénédicte , Carmeliet Peter , Gysemans Conny , De Baetselier Patrick , Mazzone Massimiliano , Van Ginderachter Jo A.
Published: April 2023

PDF - 49K, Description of additional methods and procedures used in the study. Also includes supplementary references.
Supplementary Figures 1 - 5 from Casein Kinase 1ϵ Promotes Cell Proliferation by Regulating mRNA Translation
Authors: Shin Sejeong , Wolgamott Laura , Roux Philippe P. , Yoon Sang-Oh
Published: April 2023

PDF file - 186K, Generation of CK1 isoform knockdown cells (S1); Effect of CK1epsilon inhibitor on cell death (S2); CK1epsilon expression in cancer tissue (S3); CK1epsilon interacts with 4E-BP1 (S4); CK1epsilon phosphorylates 4E-BP1 at T41/T50 (S5).
Supplementary Figure 1 from Endogenous Two-Photon Fluorescence Imaging Elucidates Metabolic Changes Related to Enhanced Glycolysis and Glutamine Consumption in Precancerous Epithelial Tissues
Authors: Varone Antonio , Xylas Joanna , Quinn Kyle P. , Pouli Dimitra , Sridharan Gautham , McLaughlin-Drubin Margaret E. , Alonzo Carlo , Lee Kyongbum , Münger Karl , Georgakoudi Irene
Published: April 2023

PDF file - 287KB, Representative autofluorescence images and 3D renderings for each type of EETE.
Supplementary Figure 1 from Mixed Lineage Kinase MLK4 Is Activated in Colorectal Cancers Where It Synergistically Cooperates with Activated RAS Signaling in Driving Tumorigenesis
Authors: Martini Miriam , Russo Mariangela , Lamba Simona , Vitiello Elisa , Crowley Emily Hannah , Sassi Francesco , Romanelli Davide , Frattini Milo , Marchetti Antonio , Bardelli Alberto
Published: April 2023

PDF file - 211K, A) Tumors formed by A549 cancer cells expressing wild type or two MLK4 mutants in xenograft mouse models. Cells were injected in the side of nude mice and tumor growth was measured at the indicated time points. Error bars represent s.e.m. B) Upon sacrifice the lungs were labeled by airway perfusion with the India ink, and superficial metastases were counted as described in panel C.*p value < 0.05; **p value < 0.01; error bars represent s.e.m.
Supplementary Table 2 from Natural Human Plasmacytoid Dendritic Cells Induce Antigen-Specific T-Cell Responses in Melanoma Patients
Authors: Tel Jurjen , Aarntzen Erik H.J.G. , Baba Tetsuro , Schreibelt Gerty , Schulte Barbara M. , Benitez-Ribas Daniel , Boerman Otto C. , Croockewit Sandra , Oyen Wim J.G. , van Rossum Michelle , Winkels Gregor , Coulie Pierre G. , Punt Cornelis J.A. , Figdor Carl G. , de Vries I. Jolanda M.
Published: April 2023

Supplementary Table 2 PDF file - 30K, Patient characteristics and historical controls
Supplementary Figure 1 from FOXC2 Expression Links Epithelial–Mesenchymal Transition and Stem Cell Properties in Breast Cancer
Authors: Hollier Brett G. , Tinnirello Agata A. , Werden Steven J. , Evans Kurt W. , Taube Joseph H. , Sarkar Tapasree Roy , Sphyris Nathalie , Shariati Maryam , Kumar Sreedevi V. , Battula Venkata L. , Herschkowitz Jason I. , Guerra Rudy , Chang Jeffrey T. , Miura Naoyuki , Rosen Jeffrey M. , Mani Sendurai A.
Published: April 2023

Supplementary Figure 1 PDF File - 22K, FOXC2 does not regulate the expression of other EMT factors. Quantification of EMT marker mRNA expression by quantitative real-time PCR analysis. Data is represented as the expression of EMT markers in HMLER-FOXC2 (FOXC2) cells relative to HMLER control cells GAPDH was used as an internal normalization control. Columns indicate the mean (n = 3); error bars indicate SEM.
Supplementary Figure 1 from Myeloid-Specific Expression of Ron Receptor Kinase Promotes Prostate Tumor Growth
Authors: Gurusamy Devikala , Gray Jerilyn K. , Pathrose Peterson , Kulkarni Rishikesh M. , Finkleman Fred D. , Waltz Susan E.
Published: April 2023

PDF file - 194K, Loss of Ron increases the migratory potential of macrophages in vivo and in vitro. For Review and Publication Both.
Supplementary Table 2 from Automated Tracking of Nanoparticle-labeled Melanoma Cells Improves the Predictive Power of a Brain Metastasis Model
Authors: Sundstrøm Terje , Daphu Inderjit , Wendelbo Ingvild , Hodneland Erlend , Lundervold Arvid , Immervoll Heike , Skaftnesmo Kai Ove , Babic Michal , Jendelova Pavla , Sykova Eva , Lund-Johansen Morten , Bjerkvig Rolf , Thorsen Frits
Published: April 2023

PDF file - 94K, CellProfiler pipeline for spheroid growth analysis
Supplementary Methods, Figures 1 - 6 from Accumulation of Memory Precursor CD8 T Cells in Regressing Tumors following Combination Therapy with Vaccine and Anti-PD-1 Antibody
Authors: Karyampudi Lavakumar , Lamichhane Purushottam , Scheid Adam D. , Kalli Kimberly R. , Shreeder Barath , Krempski James W. , Behrens Marshall D. , Knutson Keith L.
Published: April 2023

PDF file - 418KB, Supplementary Methods and Results Fig. S1. In vitro blockade of PD-1 on TUBO cells does not inhibit cell growth. Fig. S2. CD4 T cells and CD4 Tregs in TUBO TILs. Fig. S3. Combination therapy enhances the antigen-specific function of tumor-infiltrating lymphocytes. Fig. S4. Antigen-specific production IL-5 and IL-4 by tumor-infiltrating CD8 T cells. Fig. S5. Combination therapy decreased the number of tumor-infiltrating myeloid derived suppressor cells (MDSCs). Fig S6. PD-1 expression on tumor DCs and splenic CD8 T cells in co-culture.
Supplementary Table 1 from Genome-wide Profiling of AP-1–Regulated Transcription Provides Insights into the Invasiveness of Triple-Negative Breast Cancer
Authors: Zhao Chunyan , Qiao Yichun , Jonsson Philip , Wang Jian , Xu Li , Rouhi Pegah , Sinha Indranil , Cao Yihai , Williams Cecilia , Dahlman-Wright Karin
Published: April 2023

PDF file - 20KB, Chromosomal positions of Fra-1 and c-Jun co-occupied regions.
Supplementary Materials and Methods from Genome-wide Profiling of AP-1–Regulated Transcription Provides Insights into the Invasiveness of Triple-Negative Breast Cancer
Authors: Zhao Chunyan , Qiao Yichun , Jonsson Philip , Wang Jian , Xu Li , Rouhi Pegah , Sinha Indranil , Cao Yihai , Williams Cecilia , Dahlman-Wright Karin
Published: April 2023

PDF file - 32KB
Supplementary Figure 5 from Definition of Molecular Determinants of Prostate Cancer Cell Bone Extravasation
Authors: Barthel Steven R. , Hays Danielle L. , Yazawa Erika M. , Opperman Matthew , Walley Kempland C. , Nimrichter Leonardo , Burdick Monica M. , Gillard Bryan M. , Moser Michael T. , Pantel Klaus , Foster Barbara A. , Pienta Kenneth J. , Dimitroff Charles J.
Published: April 2023

PDF file - 125K, Chemokine receptor expression is variably expressed on human PCa cell lines and on localized and metastatic PCa tissue
Supplementary Figure 3 from HDAC6 Inhibition Restores Ciliary Expression and Decreases Tumor Growth
Authors: Gradilone Sergio A. , Radtke Brynn N. , Bogert Pamela S. , Huang Bing Q. , Gajdos Gabriella B. , LaRusso Nicholas F.
Published: April 2023

PDF file - 30K, Proliferation assessed with Click-iT EdU Alexa Fluor 488 Cell Proliferation Assay Kit
Supplementary Figure 2 from HDAC6 Inhibition Restores Ciliary Expression and Decreases Tumor Growth
Authors: Gradilone Sergio A. , Radtke Brynn N. , Bogert Pamela S. , Huang Bing Q. , Gajdos Gabriella B. , LaRusso Nicholas F.
Published: April 2023

PDF file - 158K, IFT88, Kif3a, and Cep164 shRNA knock-down analysis
Supplementary Table 2 from Phosphatidylinositol 4-Phosphate in the Golgi Apparatus Regulates Cell–Cell Adhesion and Invasive Cell Migration in Human Breast Cancer
Authors: Tokuda Emi , Itoh Toshiki , Hasegawa Junya , Ijuin Takeshi , Takeuchi Yukiko , Irino Yasuhiro , Fukumoto Miki , Takenawa Tadaomi
Published: April 2023

PDF file - 303K, Supplementary Table 2. PI4KIIIbeta expression in cancer.
Supplementary Table 1 from Phosphatidylinositol 4-Phosphate in the Golgi Apparatus Regulates Cell–Cell Adhesion and Invasive Cell Migration in Human Breast Cancer
Authors: Tokuda Emi , Itoh Toshiki , Hasegawa Junya , Ijuin Takeshi , Takeuchi Yukiko , Irino Yasuhiro , Fukumoto Miki , Takenawa Tadaomi
Published: April 2023

PDF file - 296K, Supplementary Table 1. SAC1 expression in cancer.
Supplementary Methods, Figures 1 - 4, Tables 2 - 6 from The Noncoding RNA MALAT1 Is a Critical Regulator of the Metastasis Phenotype of Lung Cancer Cells
Authors: Gutschner Tony , Hämmerle Monika , Eißmann Moritz , Hsu Jeff , Kim Youngsoo , Hung Gene , Revenko Alexey , Arun Gayatri , Stentrup Marion , Groß Matthias , Zörnig Martin , MacLeod A. Robert , Spector David L. , Diederichs Sven
Published: April 2023

PDF file - 808K, Supplementary Figure S1: This figure depicts the impact of MALAT1 loss on gene expression, splicing and SR protein phosphorylation. Supplementary Figure S2: This figure describes the generation of MALAT1-Knockout A549 cells using an independent ZFN as well as their phenotypes regarding proliferation and MALAT1 target gene expression. Supplementary Figure S3: This figure displays the impact of loss of MALAT1 using an independent ZFN in A549 cells on cell migration. Supplementary Figure S4: This figure documents that Antisense Oligonucleotides (ASOs) are effective in silencing MALAT1 in vitro without affecting cell proliferation of EBC-1 cells. Supplementary Table S2: This table lists 23 genes whose differential expression (5 up / 18 down) in MALAT1 KO cells was validated via qRT-PCR and who had been previously identified with critical roles in lung cancer, migration, invasion, EMT or metastasis. Supplementary Table S3: This table lists the sequences of all primers used for qRT-PCR in 5'-3' direction. Supplementary Table S4: This table lists the sequences of all primers used for splicing analysis in 5'-3' direction. Supplementary Table S5: This table lists the sequences of all primers and probes used for TaqMan qRT-PCR in 5'-3' direction. Supplementary Table S6: This table lists the sequences of all Antisense Oligonucleotides (ASOs) in 5'-3' direction. Supplementary Methods: This chapter provides experimental details on the RNA isolation and DNase I digest, reverse transcription and quantitative PCR, exon microarray analysis, antisense oligonucleotides (ASOs), lung imaging by microCT scan, immunohistochemistry and in situ hybridization, statistical analysis, generation of ZFN-2 clones, cell proliferation assays, SDS-PAGE and Western blotting.
Supplementary Movie 3 from Tumor Suppressor NF2/Merlin Is a Microtubule Stabilizer
Authors: Smole Zlatko , Thoma Claudio R. , Applegate Kathryn T. , Duda Maria , Gutbrodt Katrin L. , Danuser Gaudenz , Krek Wilhelm
Published: April 2023

MOV file - 4174K, Speed track visualization of Movie 2, speeds between 0 to 30 microm/min are color-coded (bar on the left: min, dark blue to max, dark red).
Supplementary Movie 1 from Tumor Suppressor NF2/Merlin Is a Microtubule Stabilizer
Authors: Smole Zlatko , Thoma Claudio R. , Applegate Kathryn T. , Duda Maria , Gutbrodt Katrin L. , Danuser Gaudenz , Krek Wilhelm
Published: April 2023

MOV file - 1613K, Examples of a high quality (left) and a low quality (right) EB3-GFP movie (raw data), acquisition of 125 frames, 1.25 Hz, 10 fold accelerated.
Supplementary Figure 3 from Phosphorylation of Ribosomal Protein S6 Attenuates DNA Damage and Tumor Suppression during Development of Pancreatic Cancer
Authors: Khalaileh Abed , Dreazen Avigail , Khatib Areej , Apel Roy , Swisa Avital , Kidess-Bassir Norma , Maitra Anirban , Meyuhas Oded , Dor Yuval , Zamir Gideon
Published: April 2023

PDF file - 39K, Pathologic score of PanIN lesions in Pdx1-Cre; LSL-KRAS G12D mice, wild type (n=4 mice) or heterozygous (n=7) for the phospho-rpS6 mutant.
Supplementary Figure S3 from Arkadia Regulates Tumor Metastasis by Modulation of the TGF-β Pathway
Authors: Briones-Orta Marco A. , Levy Laurence , Madsen Chris D. , Das Debipriya , Erker Yigit , Sahai Erik , Hill Caroline S.
Published: April 2023

Supplementary Figure S3 PDF File - 152K, Deletion or mutation of Smad4 results in a resistance to TGF-�-induced Ski and SnoN degradation
Supplementary Figure 1 from Cancer-Associated Fibroblasts Expressing CXCL14 Rely upon NOS1-Derived Nitric Oxide Signaling for Their Tumor-Supporting Properties
Authors: Augsten Martin , Sjöberg Elin , Frings Oliver , Vorrink Sabine U. , Frijhoff Jeroen , Olsson Eleonor , Borg Åke , Östman Arne
Published: April 2023

PDF file - 61KB, CXCL14-stimulation of fibroblasts induces Hmox1 and Nos1.
Supplementary Figure 4 from β-Catenin Activation in a Novel Liver Progenitor Cell Type Is Sufficient to Cause Hepatocellular Carcinoma and Hepatoblastoma
Authors: Mokkapati Sharada , Niopek Katharina , Huang Le , Cunniff Kegan J. , Ruteshouser E. Cristy , deCaestecker Mark , Finegold Milton J. , Huff Vicki
Published: April 2023

PDF file - 868KB, Activation of MAPK and mTOR pathways in HCCs.
Supplementary Video 1 from A Preclinical Assay for Chemosensitivity in Multiple Myeloma
Authors: Khin Zayar P. , Ribeiro Maria L.C. , Jacobson Timothy , Hazlehurst Lori , Perez Lia , Baz Rachid , Shain Kenneth , Silva Ariosto S.
Published: April 2023

MOV file - 1415K, Patient-derived MM cells (patient 14) were seeded in single (top left) and co-culture with patient-derived stroma cells (top right). They were tested for chemosensitivity to melphalan (continuous exposure for 24h, at highest concentration of 25uM, lowest concentration of 5uM). Digital image analysis algorithm detects live cells and pseudo-colors them as green. MM cells in single culture are significantly more sensitive than in co-culture, a phenomenon commonly referred to as environment-mediated drug resistance (EMDR). At 1nM, bortezomib shows no toxicity to these cells after a 24h continuous exposure (bottom left), but in combination with melphalan, it cancels EMDR (bottom right).
Supplementary Methods from Enhancement of Antitumor Immunity in Lung Cancer by Targeting Myeloid-Derived Suppressor Cell Pathways
Authors: Sawant Anandi , Schafer Cara C. , Jin Tong Huan , Zmijewski Jaroslaw , Tse Hubert M. , Roth Justin , Sun Zhihuan , Siegal Gene P. , Thannickal Victor J. , Grant Stefan C. , Ponnazhagan Selvarangan , Deshane Jessy S.
Published: April 2023

PDF file - 31K, Description of additional methods and procedures used in the study.
Supplementary Figure Legends from Effects of Notch Signaling on Regulation of Myeloid Cell Differentiation in Cancer
Authors: Cheng Pingyan , Kumar Vinit , Liu Hao , Youn Je-In , Fishman Mayer , Sherman Simon , Gabrilovich Dmitry
Published: April 2023

PDF - 28K, Legend for Supplemental Figures S1-S2.
Supplementary Figure 1 from A Preclinical Assay for Chemosensitivity in Multiple Myeloma
Authors: Khin Zayar P. , Ribeiro Maria L.C. , Jacobson Timothy , Hazlehurst Lori , Perez Lia , Baz Rachid , Shain Kenneth , Silva Ariosto S.
Published: April 2023

PDF file - 50K, Loss of membrane motion precedes loss of innate fluorescence in MM fluorescent cell line.
Supplementary Figure 2 from Metalloprotease-Mediated Tumor Cell Shedding of B7-H6, the Ligand of the Natural Killer Cell–Activating Receptor NKp30
Authors: Schlecker Eva , Fiegler Nathalie , Arnold Annette , Altevogt Peter , Rose-John Stefan , Moldenhauer Gerhard , Sucker Antje , Paschen Annette , von Strandmann Elke Pogge , Textor Sonja , Cerwenka Adelheid
Published: April 2023

PDF file - 79KB, Pharmacological inhibition of protein disulfide isomerases reduces soluble B7-H6.
Supplementary Figure 1 from Metalloprotease-Mediated Tumor Cell Shedding of B7-H6, the Ligand of the Natural Killer Cell–Activating Receptor NKp30
Authors: Schlecker Eva , Fiegler Nathalie , Arnold Annette , Altevogt Peter , Rose-John Stefan , Moldenhauer Gerhard , Sucker Antje , Paschen Annette , von Strandmann Elke Pogge , Textor Sonja , Cerwenka Adelheid
Published: April 2023

PDF file - 127KB, Tumor cell supernatants modulate NKp30 expression regardless of the presence or absence of soluble B7-H6.
Supplementary Figure 4 from Taccalonolide Binding to Tubulin Imparts Microtubule Stability and Potent In Vivo Activity
Authors: Risinger A.L. , Li J. , Bennett M.J. , Rohena C.C. , Peng J. , Schriemer D.C. , Mooberry S.L.
Published: April 2023

PDF file - 218K, High magnification electron micrographs (20,000x and 50,000x) of microtubules formed in the presence of 2 mg/ml tubulin with 10 microM AJ, PTX or LAU after repolymerization at 37 degrees C for 30 min after chilling.
Supplementary Figure 3 from AMPK Activation by Oncogenesis Is Required to Maintain Cancer Cell Proliferation in Astrocytic Tumors
Authors: Ríos Marcos , Foretz Marc , Viollet Benoit , Prieto Angel , Fraga Máximo , Costoya Jose A. , Señarís Rosa
Published: April 2023

PDF file - 109K, Supplemental figure 3. Characterization of AMPK role in proliferation of astrocytes with HRasV12 expression and human glioblastoma cell lines.
Supplementary Figures 1 - 7 from 14-3-3ζ Orchestrates Mammary Tumor Onset and Progression via miR-221–Mediated Cell Proliferation
Authors: Rehman Sumaiyah K. , Li Shau-Hsuan , Wyszomierski Shannon L. , Wang Qingfei , Li Ping , Sahin Ozgur , Xiao Yi , Zhang Siyuan , Xiong Yan , Yang Jun , Wang Hai , Guo Hua , Zhang Jitao D. , Medina Daniel , Muller William J. , Yu Dihua
Published: April 2023

PDF file - 1165K, Characterization of 14-3-3zeta Transgenic Mice and Mammary Tumors (S1); Analysis of Metastasis in Mammary Tumors (S2); Apoptosis Assays in Transgenic Mice and Cell Lines (S3); IHe Staining of Ki-67 and p21 Expression (S4); p27-Targeting miRNA Expression in Human Breast Cancer Cell Lines (S5); Analysis of Signaling Pathways Involved in 14-3-3zeta-Mediated miR-221 Transcriptional Upregulation (S6); Logistic regression model (S7).
Supplementary Information from ATIP3, a Novel Prognostic Marker of Breast Cancer Patient Survival, Limits Cancer Cell Migration and Slows Metastatic Progression by Regulating Microtubule Dynamics
Authors: Molina Angie , Velot Lauriane , Ghouinem Lydia , Abdelkarim Mohamed , Bouchet Benjamin Pierre , Luissint Anny-Claude , Bouhlel Imène , Morel Marina , Sapharikas Elène , Di Tommaso Anne , Honoré Stéphane , Braguer Diane , Gruel Nadège , Vincent-Salomon Anne , Delattre Olivier , Sigal-Zafrani Brigitte , André Fabrice , Terris Benoit , Akhmanova Anna , Di Benedetto Mélanie , Nahmias Clara , Rodrigues-Ferreira Sylvie
Published: April 2023

Supplementary Information PDF file - 115K, Supplemental materials and methods, legends to Movies and supplemental references
Supplementary Video 6 from Galectin-1 Drives Pancreatic Carcinogenesis through Stroma Remodeling and Hedgehog Signaling Activation
Authors: Martínez-Bosch Neus , Fernández-Barrena Maite G. , Moreno Mireia , Ortiz-Zapater Elena , Munné-Collado Jessica , Iglesias Mar , André Sabine , Gabius Hans-Joachim , Hwang Rosa F. , Poirier Françoise , Navas Carolina , Guerra Carmen , Fernández-Zapico Martin E. , Navarro Pilar
Published: April 2023

AVI file - 2998KB, Supplementary video 6 (Related to Supplementary Figure 4C). Time lapse video microscopy in SK-PC-1 cells infected with a Gal1 shRNA (shGal1#2). Frames were collected every 15 min for 12h.
Supplementary Figure 3 from Parathyroid Hormone–Related Protein Drives a CD11b+Gr1+ Cell–Mediated Positive Feedback Loop to Support Prostate Cancer Growth
Authors: Park Serk In , Lee Changki , Sadler W. David , Koh Amy J. , Jones Jacqueline , Seo Jung Won , Soki Fabiana N. , Cho Sun Wook , Daignault Stephanie D. , McCauley Laurie K.
Published: April 2023

PDF file - 2058K, Supplemental Fig. 3 CD11b+Gr1+ cells do not express receptors for PTHrP.
Supplementary Table 2 from Galectin-1 Drives Pancreatic Carcinogenesis through Stroma Remodeling and Hedgehog Signaling Activation
Authors: Martínez-Bosch Neus , Fernández-Barrena Maite G. , Moreno Mireia , Ortiz-Zapater Elena , Munné-Collado Jessica , Iglesias Mar , André Sabine , Gabius Hans-Joachim , Hwang Rosa F. , Poirier Françoise , Navas Carolina , Guerra Carmen , Fernández-Zapico Martin E. , Navarro Pilar
Published: April 2023

XLS file - 102KB, Gene expression profile by microarray analysis of PANC-1 cells with endogenous or downregulated Gal1 levels. List of genes differentially expressed between shGal1 and shCtl in untransfected PANC-1 cells (wt) and cells transfected with a shCtl or with shGal1 selected by P < .0005.
Supplementary Figure 1 from Parathyroid Hormone–Related Protein Drives a CD11b+Gr1+ Cell–Mediated Positive Feedback Loop to Support Prostate Cancer Growth
Authors: Park Serk In , Lee Changki , Sadler W. David , Koh Amy J. , Jones Jacqueline , Seo Jung Won , Soki Fabiana N. , Cho Sun Wook , Daignault Stephanie D. , McCauley Laurie K.
Published: April 2023

PDF file - 7060K, Supplemental Fig. 1 Ectopic PTHrP increased CD11b+Gr1+ cell-dependent prostate tumors angiogenesis.
Supplementary Figure 1 from EGFR-Mediated Chromatin Condensation Protects KRAS-Mutant Cancer Cells against Ionizing Radiation
Authors: Wang Meng , Kern Ashley M. , Hülskötter Marieke , Greninger Patricia , Singh Anurag , Pan Yunfeng , Chowdhury Dipanjan , Krause Mechthild , Baumann Michael , Benes Cyril H. , Efstathiou Jason A. , Settleman Jeff , Willers Henning
Published: April 2023

PDF file - 250KB, Effect of EGFR inhibition on short-term survival/proliferation in a NSCLC cell panel.
Supplementary Table 1 from Hyperpolarized 13C-Pyruvate Magnetic Resonance Reveals Rapid Lactate Export in Metastatic Renal Cell Carcinomas
Authors: Keshari Kayvan R. , Sriram Renuka , Koelsch Bertram L. , Van Criekinge Mark , Wilson David M. , Kurhanewicz John , Wang Zhen J.
Published: April 2023

PDF file-77KB, Table of metabolite 31P chemical shifts (�) and T1 relaxation times at 500MHz, measured in living UMRC6 cells within the bioreactor.
Supplementary Figure 1 from Hyperpolarized 13C-Pyruvate Magnetic Resonance Reveals Rapid Lactate Export in Metastatic Renal Cell Carcinomas
Authors: Keshari Kayvan R. , Sriram Renuka , Koelsch Bertram L. , Van Criekinge Mark , Wilson David M. , Kurhanewicz John , Wang Zhen J.
Published: April 2023

PDF file-63KB, Representative 31P spectra of HK-2, UMRC6 and UOK262 cell lines.
Supplementary Methods from Chemotherapy Alters Monocyte Differentiation to Favor Generation of Cancer-Supporting M2 Macrophages in the Tumor Microenvironment
Authors: Dijkgraaf Eveline M. , Heusinkveld Moniek , Tummers Bart , Vogelpoel Lisa T.C. , Goedemans Renske , Jha Veena , Nortier Johan W.R. , Welters Marij J.P. , Kroep Judith R. , van der Burg Sjoerd H.
Published: April 2023

PDF file - 67K
Supplementary Figure 3 from Chemotherapy Alters Monocyte Differentiation to Favor Generation of Cancer-Supporting M2 Macrophages in the Tumor Microenvironment
Authors: Dijkgraaf Eveline M. , Heusinkveld Moniek , Tummers Bart , Vogelpoel Lisa T.C. , Goedemans Renske , Jha Veena , Nortier Johan W.R. , Welters Marij J.P. , Kroep Judith R. , van der Burg Sjoerd H.
Published: April 2023

PDF file - 574K, CC8 (a cervical cancer cell line) transfected with short hairpin control (shControl) or with PRDX1-specific shRNA (shPRDX1) were untreated or cultured with cisplatin or carboplatin. RNA was isolated and mRNA levels of PTGS1 (COX-1), PTGS2 (COX-2) and IL-6 were analyzed by quantitative PCR. Representative experiment of two experiments.
Supplementary Figure 5 from RNAi-Mediated Silencing of Myc Transcription Inhibits Stem-like Cell Maintenance and Tumorigenicity in Prostate Cancer
Authors: Civenni Gianluca , Malek Anastasia , Albino Domenico , Garcia-Escudero Ramon , Napoli Sara , Di Marco Stefano , Pinton Sandra , Sarti Manuela , Carbone Giuseppina M. , Catapano Carlo V.
Published: April 2023

PDF file - 38K, PC3 cells cultured in sphere forming conditions (bulk) and sorted subpopulations (CD44+/CD24- and CD44+/CD24+) were transfected with Myc13-Cy3 siRNA and the intracellular level of Cy3-labeled siRNA was determined after 4 h by flow cytometry.
Supplementary Figure 2 from RNAi-Mediated Silencing of Myc Transcription Inhibits Stem-like Cell Maintenance and Tumorigenicity in Prostate Cancer
Authors: Civenni Gianluca , Malek Anastasia , Albino Domenico , Garcia-Escudero Ramon , Napoli Sara , Di Marco Stefano , Pinton Sandra , Sarti Manuela , Carbone Giuseppina M. , Catapano Carlo V.
Published: April 2023

PDF file - 92K, Tumor-initiating capability of sphere-forming and adherent growing PC3 cells.