bluuebunny/crossref_metadata_2025 huggingface dataset:
Surgical treatment of infective endocarditis in intravenous drug abusers
Authors: Zubarevich Alina , Szczechowicz Marcin , Osswald Anja , Easo Jerry , Rad Arian Arjomandi , Vardanyan Robert , Schmack Bastian , Ruhparwar Arjang , Zhigalov Konstantin , Weymann Alexander
Published: April 2021

Background

Despite current progress in antibiotic therapy and medical management, infective endocarditis remains a serious condition presenting with high mortality rates. It also is a life-threatening complication in patients with a history of chronic intravenous drug abuse. In this study, we analyzed our institutional experience on the surgical therapy of infective endocarditis in patients with active intravenous drug abuse. The aim of the study is to identify the predictive factors of mortality and morbidity in this subgroup of patients.

Methods

Between 2007 and 2020, a total of 24 patients (7 female, mean age 38.5 ± 8.7) presenting with active intravenous drug abuse underwent a surgical treatment for the infective endocarditis at out center. The primary endpoint was survival at 30th day after the surgery. The secondary composite endpoint included freedom from death, recurrent endocarditis, re-do surgery, and postoperative stroke during the follow-up period. Mean follow-up was 4.2 ± 4.3 years.

Results

Staphylococcus species was the most common pathogen detected in the preoperative blood cultures. Infection caused by Enterococcus species as well as liver function impairment were identified as mortality predictor factors. Logistic EuroSCORE and EusoSCORE-II were also predictive factors for mortality in univariate analysis. Survival at 1 and 3 years was 78 and 72% respectively. Thirty-day survival was 88%. 30-day freedom from combined endpoint was 83% and after 1 and 3 years, 69 and 58% of the patients respectively were free from combined endpoint. Five patients (20.8%) were readmitted with recurrent infective endocarditis.

Conclusion

In patients presenting with active intravenous drug abuse, treatment of infective endocarditis should be performed as aggressively as possible and should be followed by antibiotic therapy to avoid high mortality rates and recurrent endocarditis. Early intervention is advisable in patients with an infective endocarditis and enterococcus species in the preoperative blood cultures, liver function deterioration as well as cardiac function impairment. Attention should be also payed to addiction treatment, due to the elevated relapse rate in patients who actively inject drugs. However, larger prospective studies are necessary to support our results. As septic shock is the most frequent cause of death, new treatment options, e.g. blood purification should be evaluated.
Musculoskeletal impairment among Syrian refugees living in Sultanbeyli, Turkey: prevalence, cause, diagnosis and need for related services and assistive products
Authors: Boggs Dorothy , Atijosan-Ayodele Oluwarantimi , Yonso Hisem , Scherer Nathaniel , O’Fallon Timothy , Deniz Gülten , Volkan Selin , Örücü Ahmed , Pivato Isotta , Beck Ammar Hasan , Akıncı İbrahim , Kuper Hannah , Foster Allen , Patterson Andrea , Polack Sarah
Published: April 2021

Background

Epidemiological data on musculoskeletal impairment (MSI) and related service and assistive product (AP) needs for displaced populations are lacking. This study aimed to estimate the prevalence, aetiology, and specific MSI diagnosis and the need for related services and APs among Syrian refugees living in Sultanbeyli, a district in Istanbul, Turkey.

Methods

A population-based survey used probability proportionate to size and compact segment sampling to select 80 clusters (‘street’) of 50 individuals (aged 2+), for total sample size of approximately 4000 participants. An updated version of the Rapid Assessment of MSI tool (RAM) was used to screen all participants using six questions. Any participant who screened positive underwent a standardised examination by a physiotherapist to assess the presence, aetiology, severity and specific diagnosis of MSI and an assessment of need for related services and APs.

Results

The all-age prevalence of MSI was 12.2% (95% CI 10.8–13.7) and this increased significantly with age to 43.8% in people 50 and older. Over half (51%) of MSI was classified as moderate, 30% as mild and 19% as severe. The war in Syria was identified as the direct cause for 8% of people with MSI. The majority (56%) of MSI diagnoses were acquired non-traumatic causes. There was high unmet need for rehabilitation services; for example, 83% of people with MSI could benefit from physiotherapy but were not receiving this service. Overall, 19% of people with MSI had an unmet need for at least one AP. Apart from availability of walking sticks/canes, coverage was low with less than half the people with MSI who needed APs and services had received them. The most common reasons for not seeking services and APs were ‘need not felt’, lack of service availability and of awareness of services, and financial barriers.

Conclusions

MSI is common among the Syrian refugee population living in Sultanbeyli District, particularly older adults, however less than half have been able to access relevant services and APs. These findings can inform the planning of health services for migrant populations, including the essential integration of rehabilitation and APs, and increase access to these vital services.
Effects of the Mental Health First Aid for the suicidal person course on beliefs about suicide, stigmatising attitudes, confidence to help, and intended and actual helping actions: an evaluation
Authors: Bond Kathy S. , Cottrill Fairlie A. , Mackinnon Andrew , Morgan Amy J. , Kelly Claire M. , Armstrong Greg , Kitchener Betty A. , Reavley Nicola J. , Jorm Anthony F.
Published: April 2021

Background

Suicide is a significant concern in Australia and globally. There is a strong argument for training community gatekeepers in how to recognise and support suicidal people in their social network. One such training course is the Mental Health First Aid for the Suicidal Person course. This course was developed using suicide prevention best practice guidelines based on expert opinion (determined using the Delphi Method).

Methods

We evaluated the impact of attending the Mental Health First Aid for the Suicidal Person course on suicide literacy and stigma, confidence in and quality of intended and actual helping behaviours towards a person who is suicidal, and course satisfaction. Surveys were administered before and immediately after the course, and at 6-month follow-up. Data were analysed to yield descriptive statistics (percentages, means, standard deviations), with linear mixed models and generalized linear mixed models being used to test the statistical significance of changes over occasions of measurement.

Results

We recruited 284 participants from workplaces and general community networks. The mean age was 41 years and 74% were female. 85% of people undertook the course as part of professional development, and almost half (44%) did the course because they had contact with a suicidal person. The majority (59%) of participants had previous mental health and suicide prevention training. The majority of participants held knowledge (suicide literacy) before undertaking the course. The major effect of training was to strengthen this knowledge. There was a significant improvement from pre-course (M = 1.79, SD 0.56) to post-course (M = 1.48, SD 0.82, p < 0.0001), which was maintained at follow-up (M = 1.51, SD 0.49, p < 0.0001). Confidence in gatekeeper skills significantly improved after the course and at follow-up (M = 3.15, SD 0.95 before the course to M = 4.02, SD 0.68 afterward and 3.87, SD 0.77 at follow-up, p < 0.0001 and p < 0.0001, respectively). The quality of intended helping behaviours significantly improved from pre-course (intended actions M = 4.28, SD 0.58) and to post-course (M = 4.70, SD 0.50, p < 0.0001) and were maintained at follow-up (M = 4.64, SD 0.41, p < 0.0001). There was significant improvement in some of the actions taken by participants to help a suicidal person from pre-course to post-course (e.g. asking about suicidal thoughts and plan, contacting emergency services). The course was highly acceptable to participants.

Conclusion

These results indicate that this course is an acceptable intervention that delivers a broad spectrum of beneficial outcomes to community and workplace gatekeepers.
The effects of nano-curcumin as a nutritional strategy on clinical and inflammatory factors in children with cystic fibrosis: the study protocol for a randomized controlled trial
Authors: Talebi Saeedeh , Safarian Mahammad , Jaafari Mahmood Reza , Sayedi Seyed Javad , Abbasi Zahra , Ranjbar Golnaz , Kianifar Hamid Reza
Published: April 2021

Background

Cystic fibrosis (CF) is a genetic disorder, which is caused by the CFTR protein defects. Along with CFTR dysfunction, inflammation plays a key role in the disease outcomes. Inflammation may develop due to the internal dysfunction of the CFTR protein or external factors. Curcumin affects the CFTR protein function primarily as a corrector and potentiator and secondary as an anti-inflammatory and antimicrobial agent. The present study aims to assess the impact of nano-curcumin on clinical and inflammatory markers in children with CF.

Methods

This prospective, double blind control trial will be conducted at the Akbar Children’s Hospital in Mashhad, Iran. Children with CF will be enrolled based on the eligibility criteria. Placebo and curcumin with the maximum dose of 80 mg considering the body surface of the patients will be administrated for 3 months. The primary outcome is to evaluate inflammation based on serum interleukin-6, interleukin-10, and hs-CRP, stool calprotectin, and neutrophil count of nasopharyngeal swab. The secondary outcome involved clinical assessment via spirometry, anthropometrics, and quality of life. They will be assessed before and after 3 months.

Discussion

Due to the multifarious effects of curcumin on CF disease, it could be proposed as a nutritional strategy in the treatment of cystic fibrosis.

Trial registration

Iranian Registry of Clinical Trials IRCT20200705048018N1. Registered on July 10, 2020.
CRISPR/Cas12a-based on-site diagnostics of Cryptosporidium parvum IId-subtype-family from human and cattle fecal samples
Authors: Yu Fuchang , Zhang Kaihui , Wang Yilin , Li Dongfang , Cui Zhaohui , Huang Jianying , Zhang Sumei , Li Xiaoying , Zhang Longxian
Published: April 2021

Background

Cryptosporidium parvum is an enteric protozoan parasite with zoonotic importance and can cause cryptosporidiosis in humans as well as domestic and wild animals worldwide. The IId subtype family (SF) is one of the most prevalent subtypes of C. parvum. Some clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated (Cas) protein systems have been developed to detect nucleic acid with high flexibility, sensitivity and specificity.

Methods

By integrating recombinase polymerase amplification and the Cas12a/crRNA trans-cleavage system (termed ReCTC), we established end-point diagnostics by observing fluorescence readouts with the naked eye under blue light and on-site diagnostics using a lateral flow strip (LFS) biosensor.

Results

Our ReCTC-based diagnoses can detect as little as a single copy of a cloned C. parvum 60-kDa glycoprotein (GP60) gene, 10 oocysts per gram (OPG), clinical fecal sample without tedious extraction of genomic DNA and have no cross-reactivity with other SFs of C. parvum or other common enteric parasitic protozoa.

Conclusions

This study provided a new strategy for direct identification of the IId SF of C. parvum free of highly trained operators and expensive special equipment.

Graphical Abstract
High-frequency ultrasound in clinical dermatology: a review
Authors: Levy Jack , Barrett Devon L. , Harris Nile , Jeong Jiwoong Jason , Yang Xiaofeng , Chen Suephy C.
Published: April 2021

Background

Ultrasound was first introduced in clinical dermatology in 1979. Since that time, ultrasound technology has continued to develop along with its popularity and utility.

Main text summary

Today, high-frequency ultrasound (HFUS), or ultrasound using a frequency of at least 10 megahertz (MHz), allows for high-resolution imaging of the skin from the stratum corneum to the deep fascia. This non-invasive and easy-to-interpret tool allows physicians to assess skin findings in real-time, enabling enhanced diagnostic, management, and surgical capabilities. In this review, we discuss how HFUS fits into the landscape of skin imaging. We provide a brief history of its introduction to dermatology, explain key principles of ultrasonography, and review its use in characterizing normal skin, common neoplasms of the skin, dermatologic diseases and cosmetic dermatology.

Conclusion

As frequency advancements in ultrasonography continue, the broad applications of this imaging modality will continue to grow. HFUS is a fast, safe and readily available tool that can aid in diagnosing, monitoring and treating dermatologic conditions by providing more objective assessment measures.
Post-anesthesia care unit desaturation in adult deep extubation patients
Authors: Juang Jeremy , Cordoba Martha , Xiao Mark , Ciaramella Alex , Goldfarb Jeremy , Bayter Jorge Enrique , Macias Alvaro Andres
Published: April 2021

Objective

Deep extubation refers to endotracheal extubation performed while a patient is deeply anesthetized and without airway reflexes. After deep extubation, patients are sent to the post-anesthesia care unit (PACU) to recover, an area with notably different management and staffing than the operating room (OR). One of the most frequent and concerning complications to occur in the PACU is hypoxemia. As such, this study seeks to evaluate the incidence of desaturation, defined by SpO2 < 90% for longer than 10 s, in the PACU following deep extubation. Additionally, we hope to assess the consequence of desaturation on perioperative workflow by comparing PACU recovery times.

Results

Following deep extubation, 4.3% of patients (13/300) experienced desaturation in the PACU. Every episode was notably minor, with patients reverting to normal saturation levels within a minute. Of the 26 case factors assessed, 24 had no significant association desaturation in the PACU, including the amount of time spent in the PACU. History of asthma was the only statistically significant factor found to be positively associated with desaturation. We find that PACU desaturation episodes following deep extubation are rare. Our findings suggest that deep extubation is a viable and safe option for patients without significant respiratory tract pathology.
Errors, discrepancies and underlying bias in radiology with case examples: a pictorial review
Authors: Onder Omer , Yarasir Yasin , Azizova Aynur , Durhan Gamze , Onur Mehmet Ruhi , Ariyurek Orhan Macit
Published: April 2021

Interpretation differences between radiologists and diagnostic errors are significant issues in daily radiology practice. An awareness of errors and their underlying causes can potentially increase the diagnostic performance and reduce individual harm. The aim of this paper is to review both the classification of errors and the underlying biases. Case-based examples are presented and discussed for each type of error and bias to provide greater clarity and understanding.
Identifying lumbosacral plexus nerve root abnormalities in patients with sciatica using 3T readout-segmented echo-planar diffusion weighted MR neurography
Authors: Abdulaal Osamah M. , McGee Allison , Rainford Louise , O’Driscoll Dearbhail , Galligan Marie , Reid Valerie , MacMahon Peter J.
Published: April 2021

Objectives

To investigate the accuracy of Diffusion Weighted Imaging (DWI) using the Readout Segmentation of Long Variable Echo-trains (RESOLVE) sequence in detecting lumbosacral nerve abnormalities.

Methods

Following institutional ethics committee approval, patients with sciatica-type lower limb radicular symptoms (n = 110) were recruited and prospectively scanned using 3T MRI. Additional participants (n = 17) who underwent neurophysiological testing (EMG/NCV), were also prospectively studied. In addition to routine lumbar spine MRI, a DWI-RESOLVE sequence of the lumbosacral plexus was performed. Two radiologists, blinded to the side of patient symptoms, independently evaluated the MR images. The size and signal intensity changes of the nerves were evaluated using ordinal 4-point Likert-scales. Signal-to-noise ratio (SNR), apparent diffusion coefficient (ADC) and size were measured for affected and normal nerves. Inter-observer agreement was determined with kappa statistics; κ.

Results

In patients who did not undergo EMG/NCV testing (n = 110), the DWI-RESOLVE sequence detected lumbosacral nerve abnormalities that correlated with symptoms in 36.3% (40/110). This is a similar percentage to patients who underwent EMG/NCV testing, which was positive and correlated with symptoms in 41.2% (7/17). Inter-observer agreement for evaluation of lumbosacral nerve abnormalities was excellent and ranged from 0.87 to 0.94. SNR and nerve size measurements demonstrated statistically significant differences for the L5 and S1 nerves (p value < 0.05) for patients who did not undergo EMG/NCV testing.

Conclusion

The DWI-RESOLVE sequence is a promising new method that may permit accurate detection and localization of lumbar nerve abnormalities in patients with sciatica.
Pulse deinterleaving based on fusing PDWs and PRI extraction process for radar-assisted edge devices considering computational costs
Authors: Hasani Hamid , Khosravi Mohammad R.
Published: April 2021

Deinterleaving or radar pulse separation is a very important goal in terms of radar sources for identifying and implementing electronic warfare systems. In order to separate radar pulses, parameters measured by electronic warfare receivers such as electronic warfare support measures (ESM) and electronic signals intelligence (ELINT) are used in pulse separation. This paper presents a multi-parameter improved method for separating the pulse sequence of radar signals based on time of arrival (TOA) processing with sorting the other pulse descriptor words (PDW) parameters. In the proposed method, after extracting all the pulse repetition intervals (PRIs) based on TOA, the parameters of the angle of arrival, pulse width and carrier frequency (RF) are being used in pulse sorting to separate the received interleaved pulse sequences. The sequential difference histogram (SDIF) algorithm or cumulative difference histogram (CDIF) algorithm is used to extract all pulse repetition intervals. Also, in order to separate the sequence of the received pulses from all surroundings emitters, in addition to matching the potential PRI among the TOAs of the pulses and the similarity measurement in the other parameters of the pulse sequence (pulse sorting) have been used. This proposed algorithm is implemented in the integrated and complete design for deinterleaving of the radar pulses. The proposed method by considering low-cost computing sources considers a fast and low-complexity solution that can be used for edge-enabled distributed processors in aerial radar platforms as edge devices for military/combat unmanned aerial vehicles or networked missiles. The simulation results show that our method is completely effective.
From 30 million to zero malaria cases in China: lessons learned for China–Africa collaboration in malaria elimination
Authors: Chen Jun-Hu , Fen Jun , Zhou Xiao-Nong
Published: April 2021

Malaria was once one of the most serious public health problems in China, with more than 30 million malaria cases annually before 1949. However, the disease burden has sharply declined and the epidemic areas has shrunken after the implementation of an integrated malaria control and elimination strategy, especially since 2000. Till now, China has successfully scaled up its efforts to become malaria-free and is currently being evaluated for malaria-free certification by the WHO. In the battle against malaria, China’s efforts have spanned generations, reducing from an incidence high of 122.9/10 000 (6.97 million cases) in 1954 to 0.06/10 000 (7855 cases) in 2010. In 2017, for the first time, China reached zero indigenous case of malaria, putting the country on track to record three consecutive years of zero transmission by 2020, accoding to the National Malaria Elimination Action Plan (2010–2020). China’s efforts to eliminate malaria is impressive, and the country is dedicated to sharing its lessons learned in malaria elimination—including, but not limited to, the application of novel genetics-based approaches—with other nations through new initiatives. China will promote international relationships and establish collaborative platforms on a wide range of topics in roughly 65 countries, including 20 African nations. China’s experience in applying innovative genetics-based approaches and tools to characterize malaria parasite populations, including surveillance of markers related to drug resistance, categorization of cases as indigenous or imported, and objective identification of the likely sources of infections to inform efforts towards malaria control and elimination in Africa could offer game-changing results when applied to settings with ongoing transmission.
Model-based reproduction and validation of the total spectra of a solar flare and their impact on the global environment at the X9.3 event of September 6, 2017
Authors: Watanabe Kyoko , Jin Hidekatsu , Nishimoto Shohei , Imada Shinsuke , Kawai Toshiki , Kawate Tomoko , Otsuka Yuichi , Shinbori Atsuki , Tsugawa Takuya , Nishioka Michi
Published: April 2021

We attempted to reproduce the total electron content (TEC) variation in the Earth's atmosphere from the temporal variation of the solar flare spectrum of the X9.3 flare on September 6, 2017. The flare spectrum from the Flare Irradiance Spectral Model (FISM), and the flare spectrum from the 1D hydrodynamic model, which considers the physics of plasma in the flare loop, are used in the GAIA model, which is a simulation model of the Earth's whole atmosphere and ionosphere, to calculate the TEC difference. We then compared these results with the observed TEC. When we used the FISM flare spectrum, the difference in TEC from the background was in a good agreement with the observation. However, when the flare spectrum of the 1D-hydrodynamic model was used, the result varied depending on the presence or absence of the background. This difference depending on the models is considered to represent which extreme ultraviolet (EUV) radiation is primarily responsible for increasing TEC. From the flare spectrum obtained from these models and the calculation result of TEC fluctuation using GAIA, it is considered that the enhancement in EUV emission by approximately 15–35 nm mainly contributes in increasing TEC rather than that of X-ray emission, which is thought to be mainly responsible for sudden ionospheric disturbance. In addition, from the altitude/wavelength distribution of the ionization rate of Earth's atmosphere by GAIA (Ground-to-topside Atmosphere and Ionosphere model for Aeronomy), it was found that EUV radiation of approximately 15–35 nm affects a wide altitude range of 120–300 km, and TEC enhancement is mainly caused by the ionization of nitrogen molecules.
Nonlinear wave growth theory of whistler-mode chorus and hiss emissions in the magnetosphere
Authors: Omura Yoshiharu
Published: April 2021

Nonlinear processes associated with the generation process of whistler-mode chorus emissions are summarized. The nonlinear dynamics of energetic electrons interacting with a coherent whistler-mode wave and the formation of electromagnetic electron holes or hills in the velocity phase space are described. The condition for resonant electrons to be free from the anomalous trapping at low pitch angles is obtained. In the presence of the inhomogeneity due to the frequency variation and the gradient of the magnetic field, the electron holes or hills result in resonant currents generating rising-tone emissions or falling-tone emissions, respectively. After formation of a coherent wave at a frequency of the maximum linear growth rate, triggering of the nonlinear wave growth takes place when the wave amplitude is above the threshold amplitude. The wave grows to a level close to the optimum wave amplitude as an absolute instability near the magnetic equator. The nonlinear growth rate at a position away from the equator is derived for a subtracted Maxwellian momentum distribution function with correction to the formulas in the past publications. The triggering process is repeated sequentially at progressively higher frequencies in the case of a rising-tone emission, generating subpackets forming a chorus element. With a higher plasma density as in the plasmasphere, the triggering of subpackets takes place concurrently over a wide range of frequency forming discrete hiss elements with varying frequencies. The mechanism of nonlinear wave damping due to quasi-parallel propagation from the equator is presented, which results in the formation of a gap at half the electron cyclotron frequency, separating a long rising-tone chorus emission into the upper-band and lower-band chorus emissions. The theoretical formulation of an oblique whistler mode wave and its interaction with energetic electrons at the n-th resonance is also presented along with derivation of the inhomogeneity factor.
Evaluation of the ‘Spaarne soft tissue procedure’ as a treatment for recurrent patellar dislocations: a four-in-one technique
Authors: Puijk Raymond , Rassir Rachid , Louwerens Jan K. G. , Sierevelt Inger N. , de Jong Tjitte , Nolte Peter A.
Published: April 2021

Purpose

The ‘Spaarne soft tissue procedure’, is a 4-in-1 soft tissue procedure that treats recurrent patellar dislocations in the young and active population. The procedure has not yet described elsewhere. The purpose of this study is to analyse the redislocation rate and to evaluate the postoperative knee function and patient satisfaction.

Methods

Twenty-seven patients (34 knees) underwent the four-in-one SST-procedure. The 4-step technique required a minor change in 2010, including the use of a smaller strip of the patellar tendon for transposition. After a median follow-up of 10.4 years, the redislocation rate was evaluated as the primary outcome measure. Secondary outcome measures were functional outcome (IKDC, Kujala, Lysholm and Tegner activity scale) and Numeric Rating Scales for satisfaction and pain.

Results

Redislocation occurred in 8 cases (23.5%) and subluxation occurred in 13 cases (38.2%) post-surgery. A significant higher number of redislocations and subluxations were seen before 2010 (p = 0.04, p = 0.03). The median postoperative IKDC, Lysholm and Kujala scores for the total group were 54, 76 and 81 respectively. Pre- and postoperative Tegner activity scale were both level 3. Median NRS scores during rest, walking and sports were 1, 3 and 5 respectively. Satisfaction with the procedure was reported as ‘excellent’ or ‘good’ by 79% of the patients.

Conclusion

Despite the high overall redislocation rate and increased pain scores, the SST-procedure shows to be a safe procedure in patients with recurrent patellar dislocations based on the cases after 2010. Mid- and long-term results show moderate to good functional outcomes and satisfaction.

Level of evidence

Therapeutic retrospective cohort study, LEVEL III
The value of bone marrow, liver, and spleen imaging in diagnosis, prognostication, and follow-up monitoring of myeloproliferative neoplasms: a systematic review
Authors: Slot Stefanie , van de Donk Niels W. C. J. , Otten René H. J. , Boden Bouke J. H. , Zijlstra Josée , Raijmakers Pieter G. H. M. , Zweegman Sonja
Published: April 2021

Background

Diagnostic and treatment response criteria for the JAK2/CALR/MPL mutation-related myeloproliferative neoplasms (MPNs) are largely based on bone marrow (BM) biopsy results. However, these biopsies have several limitations, such as the risk of sampling error. Also, the prognostic impact of BM abnormalities is largely unclear. Although not currently used in clinical practice, imaging techniques might offer additional information. In this review, we investigated the value of BM, liver, and spleen imaging for diagnosis, prognostication, and response monitoring of the JAK2/CALR/MPL mutation-related MPNs (i.e. essential thrombocythemia (ET), polycythemia vera (PV), and myelofibrosis (MF)).

Methods

A systematic literature search was performed via PubMed, Embase and the Cochrane Library up to 2020 March 26th. Of 5505 identified records, 55 publications met the eligibility criteria (i.e. containing original data on the imaging appearance of BM, spleen, or liver in adult ET, PV, or MF patients, published in a peer-reviewed journal, written in English).

Results

Many explorative studies described imaging features, sometimes with comparisons to clinical characteristics. Studies reporting measures of diagnostic accuracy included 1) splenic transient elastography to predict BM fibrosis grade in MF, 2) dynamic contrast-enhanced MRI to discern MF patients from ET patients and healthy controls, and 3) 18-fluorodeoxyglucose PET to detect residual disease after stem cell transplantation in MF. The diagnostic accuracies of radiography and99mTc-colloid scintigraphy were derived from several other articles. Except for the study on 18-fluorodeoxyglucose PET, we established substantial concerns regarding risk of bias and applicability across these studies, using the QUADAS-2 tool. Three publications described a correlation between imaging results and prognosis, of which one quantified the effect.

Conclusions

Based on current data, MRI (T1-weighted/STIR, Dixon) seems especially promising for the evaluation of BM fat content - and indirectly cellularity/fibrosis - in MF, and possibly for estimating BM cellularity in ET/PV. 18-fluorodeoxyglucose and 18-fluorothymidine PET/CT might be useful for evaluating BM fibrosis, with good reported accuracy of the former for the diagnosis of residual disease. Further research on these and other techniques is warranted to determine their exact value. Future researchers should improve methodology and focus on evaluation of diagnostic accuracy and prognostic implications of results.
The role of circular RNA circ_0008285 in gestational diabetes mellitus by regulating the biological functions of trophoblasts
Authors: Chen Haitian , Zhang Shaofeng , Wu Yanxin , Li Zhuyu , Wang Dongyu , Cai Shiqin , Wang Zilian
Published: April 2021

Background

Circular RNAs (circRNAs) has emerged as vital regulator involved in various diseases. In this study, we identified and investigated the potential circRNAs involved in gestational diabetes mellitus (GDM).

Methods

High-throughput sequencing was used to collect the plasma circRNAs expression profiles of GDM patients. Quantitative reverse-transcriptase polymerase chain reaction (qRT-PCR) was used to measure the expressions of circ_0008285 and circ_0001173 in the plasma specimens. The Pearson’s correlation test was employed to assess the correlation between 2 circRNAs expression and the clinicopathologic data. Two circRNAs expression was verified in high glucose (HG)-induced HTR-8/SVneo cells. MTS, transwell assay was used to evaluate the effects of circ_0008285 expression on HG-induced HTR-8/SVneo cells. The network of circ_0008285 was constructed using cytocape.

Results

In GDM patients, the expression of circ_0008285 was significantly upregulated, while that of circ_0001173 was decreased. Circ_0008285 was significantly correlated with the total cholesterol and LDL-C levels. Circ_0001173 was significantly correlated with glycated hemoglobin. HG promoted the proliferation, invasion, and migration in HTR-8/SVneo cells, while the knockdown of circ_0008285 exerted reverse effects. In addition, network construction exhibited that circ_0008285 had 45 miRNA binding sites, which correlated with 444 mRNA.

Conclusions

circ_0008285 plays an important role and provides a clue for the usage of therapeutic targets in the development of GDM.
Emergent salvage surgery for massive hemoptysis after proton beam therapy for lung cancer: a case report
Authors: Hino Haruaki , Nakahama Kahori , Ogata Makoto , Kibata Kayoko , Miyasaka Chika , Utsumi Takahiro , Maru Natsumi , Matsui Hiroshi , Taniguchi Yohei , Saito Tomohito , Tsuta Koji , Murakawa Tomohiro
Published: April 2021

Background

Salvage surgery is an effective therapeutic option for patients experiencing relapses after chemoradiotherapy for advanced-stage lung cancer or after high-dose radiotherapy for early-stage lung cancer. We report a case involving an emergent salvage surgery for a patient with massive hemoptysis who developed lung cancer recurrence after undergoing proton beam therapy 7 years prior to presentation.

Case presentation

A 70-year-old male patient was emergently admitted due to massive hemoptysis. He had undergone proton beam therapy for a stage I adenocarcinoma of the left upper lobe 7 years ago, and was receiving chemotherapy for local recurrence. We performed an emergent salvage pulmonary resection to achieve hemostasis. During the operation, we confirmed the presence of a left broncho-pulmonary arterial fistula, which was considered as the origin of the massive hemoptysis. We repaired the fistula between the pulmonary artery and left upper bronchus without incident; an orifice of the fistula at the left pulmonary artery was sutured using a non-absorbable monofilament, and the central portion of the orifice of the fistula at the left upper bronchus was closed with a mechanical stapling device. The postoperative diagnosis was of an adenocarcinoma—ypT3(pm1) N0M1a (dissemination)-IVA, ef1b. The patient has survived for over a year with the cancer in almost complete remission following the administration of an epidermal growth factor receptor tyrosine kinase inhibitor.

Conclusions

Emergent salvage surgery demands high skill levels with optimal timing and correct patient selection. Our case suggested that the procedure played an important role in controlling serious bleeding and/or infectious conditions. Consequently, he could receive chemotherapy again and survive for over a year.
Raman spectroscopic detection of interleukin-10 and angiotensin converting enzyme
Authors: Zhang Shuo , van der Mee Frederieke A. M. , Erckens Roel J. , Webers Carroll A. B. , Berendschot Tos T. J. M.
Published: April 2021

In this report we present a confocal Raman system to identify the unique spectral features of two proteins, Interleukin-10 and Angiotensin Converting Enzyme. Characteristic Raman spectra were successfully acquired and identified for the first time to our knowledge, showing the potential of Raman spectroscopy as a non-invasive investigation tool for biomedical applications.
Antimicrobial activity of bacterial endophytes from Chirata (Swertia chirata Wall.) and Datura (Datura stramonium L.)
Authors: Devi Rimashree , Nath Tankeswar , Boruah Rashmi Rekha , Darphang Bishya , Nath Pranab Kumar , Das Priyanka , Sarmah Bidyut Kumar
Published: April 2021

Background

Exploration of biocides in microbial system becomes increasingly interesting. Among the different microbial systems, the study of endophytes becomes an important field of research because of their agricultural as well as pharmaceutical importance. Bacterial endophytes from two medicinal plants from North Easter states of India had been studied for their potential antibacterial and antifungal properties.

Results

Bacterial endophytes from two medicinal plant species abundantly available in North Eastern states of India, Chirata (Swertia chirata) and Datura (Datura stramonium), had been isolated and studied for their anti-bacterial and anti-fungal activities. Six bacterial endophytes were isolated from Chirata and 5 from Datura. All these bacterial isolates were initially isolated by observing their colony morphology, and then 9 morphologically distinct bacterial isolates were identified at molecular level by their 16s rRNA sequencing. Among the identified isolates, 5 were found to be belonged to genus Staphylococcus, 2 Bacillus, and one each belonged to Rhodococcus and Cupriavidus. Antibacterial study was carried out against 2 plant pathogenic bacteria, viz., Xanthomonas oryzae and Ralstonia solanacearum. Antifungal study was carried out against 2 plant pathogenic fungi, viz., Fusarium oxysporum and F. solani. Out of 6 bacterial isolates from Chirata, one showed antibacterial as well as antifungal properties, and another one showed antifungal properties only. Likewise, out of 5 bacterial isolates from Datura, one found to have both antibacterial and antifungal properties, and another one has only antifungal properties.

Conclusion

Few bacterial endophytes isolated from S. chirata and D. stramonium L., abundantly available in North Eastern part of India, had potential antibacterial as well as antifungal properties. This could be considered as the baseline information on potential antibacterial and antifungal agents from bacterial endophytes. Further investigations are required to assess their efficacy against several other bacterial and fungal diseases of economic importance.
Applicability of PD-L1 tests to tailor triple-negative breast cancer treatment in Brazil
Authors: Leite Kátia Ramos Moreira , Barrios Carlos Henrique , Buzaid Antônio Carlos , Gagliato Débora , Gobbi Helenice , Soares Fernando
Published: April 2021

Background

Triple-negative breast cancer (TNBC) is a heterogeneous disease that represents 10–20% of breast cancer cases. The prognosis for advanced TNBC is usually poor, with a median overall survival of approximately 18 months or less.

Main text

New targeted therapies such as anti-PD-L1 agents are emerging as an option to treat advanced TNBC. A panel of 6 national experts with an active interest in breast cancer convened online. Panel members had either clinical or pathology experience in breast cancer. The experts pre-defined critical questions in the management of PD-L1 in TNBC, and a literature review was performed for selected topics before the online meeting.

Conclusion

The experts led active discussions involving a multidisciplinary team comprising pathologists and clinical oncologists. The meeting served to discuss the most relevant issues. A total of 10 critical questions for PD-L1+ TNBC were debated and are presented in this review. This article discusses the current landscape for PD-L1 tests in TNBC in Brazil.
Impact of COVID-19 pandemic and related isolation measures on violence against children in Egypt
Authors: AboKresha Seham Ahmed , Abdelkreem Elsayed , Ali Rasha Abd Elhameed
Published: April 2021

Background

Coronavirus disease 2019 (COVID-19) and related isolation measures have substantial adverse economic, social, and psychological consequences and expose children to increased risk of violence. The present study aimed to investigate the impact of the COVID-19 pandemic on violence against children in Egypt.

Methods

An online survey, in Arabic, was disseminated during the period from 9 to 13 April 2020, to parents of children who were up to 18 years old residing in Egypt, selected using a snowball sampling technique, during the period from 25 March to 8 April during the implementation of the nationwide compulsory isolation measures against COVID-19 (25 March to 8 April 2020). The survey covered three areas: socio-demographic data, psychological impact measured using the Impact of Event Scale-Revised (IES-R), and violence against children during the past 2 weeks measured using a modified parent-report of a child abuse screening tool (ICAST-P) developed by the International Society for the Prevention of Child Abuse and Neglect.

Results

Out of 1118 completed survey responses, 90.5% of children were subjected to violent discipline, 88.7% experienced psychological aggression, and 43.2% encountered severe physical punishment. Approximately 60% of respondents reported a moderate-to-severe psychological impact (IES-R scores ≥ 33), which was associated with a higher rate of violent discipline (OR: 9.3; 95% CI: 5.37–16.027; p < 0.001).

Conclusions

This is the first study in Egypt to provide evidence on the association of COVID-19 pandemic, its psychological impact, and increased rates of violence against children. Effective multilevel strategies are urgently required to protect children from violence and its catastrophic consequences during the continually evolving COVID-19 pandemic.
An Oral Myofunctional Exercise Prescription For Obstructive Sleep Apnea
Authors: Sechser Nasya R. , Overhue Hadlie L. , Van Guilder Gary P.
Published: April 2021

Apply It!

After having read this article, the health and fitness professional will be able to

▪ Describe the signs/symptoms, risk factors, and causes of obstructive sleep apnea

▪ Identify the anatomical location and functions of the primary oropharyngeal skeletal muscles

▪ Instruct how to perform oropharyngeal exercises to a client/patient

▪ Integrate evidence-based oropharyngeal exercise training into a physical activity plan for persons suffering from obstructive sleep apnea
The diagnostic value of intravoxel incoherent motion imaging in differentiating high-grade from low-grade gliomas: a systematic review and meta-analysis
Authors: Luo Hechuan , He Ling , Cheng Weiqin , Gao Sijie
Published: April 2021

Objective:

This meta-analysis was carried out for assessing the accuracy of intravoxel incoherent motion (IVIM) parameters true diffusion coefficient (D), pseudo-diffusion coefficient (D*), and perfusion fraction (f) in differentiating low-grade gliomas (LGGs) from high-grade gliomas (HGGs).

Methods:

Literatures concerning IVIM in the grading of brain gliomas published prior to October 20, 2020, searched in the Embase, PubMed, and Cochrane library. Use the quality assessment of diagnostic accuracy studies 2 (QUADAS 2) to evaluate the quality of studies. We estimated the pooled sensitivity, specificity, and the area under the summary ROC (SROC) curve to identification the accuracy of IVIM parameters D, D*, and f evaluation in grading gliomas.

Results:

Totally, 6 articles including 252 brain gliomas conform to the inclusion criteria. The pooled sensitivity of parameters D, D*, and f derived from IVIM were 0.85 (95%Cl, 0.76–0.91), 0.78 (95%Cl, 0.71–0.85), and 0.89 (95%Cl, 0.76–0.96), respectively. The pooled specificity were 0.78 (95%Cl, 0.60–0.90), 0.68 (95%Cl, 0.56–0.79), and 0.88 (95%Cl, 0.76–0.94), respectively. Meanwhile, the AUC of SROC curve were 0.89 (95%Cl, 0.86–0.92) , 0.81 (95%Cl, 0.77–0.84), and 0.94 (95%Cl, 0.92–0.96), respectively.

Conclusion:

This meta-analysis suggested that IVIM parameters D, D*, and f have moderate or high diagnosis value accuracy in differentiating HGGs from LGGs, and the parameter f has greater sensitivity and specificity. Standardized methodology is warranted to guide the use of this method for clinical decision-making. However, more clinical studies are needed to prove our view.

Advances in knowledge:

IVIM parameter f showed greater sensitivity and specificity, as well as excellent performance than parameter D* and D.
Liver metastasis mimicking an abscess
Authors: Imrani Kaoutar , Oubaddi Tlaite , Jerguigue Hounayda , Latib Rachida , Omor Youssef
Published: April 2021

Hepatic metastases from carcinoid tumours are typically solid, hypervascular lesions on imaging. The cystic form, mimicking an abscess, is extremely rare. We report a case of a 48-year-old female presenting with a large hepatic mass that was diagnosed as a hepatic abscess, but the ultrasound-guided biopsy showed well-differentiated grade 1 neuroendocrine tumour. CT scan of chest, abdomen and pelvis was performed, looking for the primary tumour, it revealed an endobronchial mass of the right inferior lobe. Lung biopsy by rigid bronchoscopy was taken confirming the diagnosis of a typical carcinoid tumour.
Unusual presentation of hepatocellular carcinoma: Case report and review of literature
Authors: Loyal Poonamjeet , Gitau Samuel , Manji Soraiya , Mwanzi Sitna , Weru John
Published: April 2021

Hepatocellular carcinoma (HCC) is the most common primary cancer of the liver and a major cause of mortality globally. Atypical presentation of HCC can present a diagnostic challenge. We, therefore, present a rare case of hepatocellular carcinoma fungating through the anterior abdominal wall with concomitant lung and brain metastases in a young patient with non-cirrhotic liver but positive chronic hepatitis B serology.
Findriver- Driven Relationship among Shariah Compliant Indian and Indonesian Indices – An Empirical Evidence using Granger Causality
Authors: Soni Badal , Roy Sarthak
Published: April 2021

This paper attempts to establish the driver-driven relationship, co-integration, and causality relation between the Shariah indices of India and Indonesia. For this reason, two Indian Shariah indices, Nifty 500 and S&P BSE 500 Shariah and two Indonesian Shariah indices IDX Shariah and Jakarta Islamic Index (JII) have been taken into consideration. A total of 1585 data points have been taken into account, and the period of the study is from May 2013 to October 2019 (approximately six years and six months). Empirical evidence of the study proves that there is reciprocity among the Shariah index of India, Nifty 500 Shariah, and S&P BSE 500 Shariah. There exists no relationship between IDX Shariah and Jakarta Islamic Index when compared with Nifty 500 Shariah, individually. IDX Shariah is a driver index, though it is 11 years younger than Jakarta Islamic Index and, which is the driven index.
Solving the Mystery of Crypto’s Bubble
Authors: Sengar Harsh
Published: April 2021

Blockchain is the vehicle on which cryptocurrencies run, and it can’t be regulated by any legal entity during its operation.The huge growth in various cryptocurrency segments in 10 years has created the controversy of an inevitable bubble. A bubble can be generated either by queer herd behaviour or logical secular movement. Traces of evident bubbles have been a certainty and they take the perceived valuation of crypto to figures far away from its true value. This sudden diversion can be lethal due to the illogical, irrational propensity of regular market participants. This study observes ten cryptos under surveillance from September 2014 to August 2019. The selected ten (Monero, Bitcoin, XRP Ripple, Litecoin, Dogecoin, Monacoin, Ethereum, Bytecoin, Digibite, Potcoin) cryptocurrencies were studied for the last five years using Right Tailed ADF Test. Prominent traces of the rational bubble in all the underlying cryptocurrencies were found and have been considered for the study.
Bankruptcy in Indian Private Sector Banks: A Neural Network Analysis
Authors: Dhama Surbhi
Published: April 2021

This paper aims to predict the bankruptcy in Indian private banks using financial ratios such as ROA, GNPA, EPS, PAT, and GNP of the country. This paper also explains the importance of Ohlson’s number, Graham’s number and Zmijewski number as the major predictors of bankruptcy while developing a model using neural networks. For the prediction, the financial data for private sector banks of India such as HDFC, HDFC, ICICI, AXIS, YES bank, KOTAK MAHINDRA Bank, FEDERAL BANK, INDUSIND Bank, RBL and KARUR VYSYA for the last 10 years from 2010-2019 have been analysed. The model developed during the research will help the financial institutions and banks in India to understand the economic condition of the banking industry.
Psychological Safety and Employee Voice in IT Sector: Parallel Mediation Effect of Affective Commitment and Intrinsic Motivation
Authors: Soumyaja Devi , Kuriakose Jeeva
Published: April 2021

The study is an attempt to explain the relationship ofpsychological safety on employee voice behaviour byexamining the mediating role of affective commitmentand intrinsic motivation. A questionnaire was distributedamongst 161 IT professionals through conveniencesampling. Mediation Analysis was used to find the effectof the mediators in influencing the relationship betweenpsychological safety and prosocial voice. The resultsuggested psychological safety is parallelly mediated byboth affective commitment and intrinsic motivation,leading to employee prosocial voice. Intrinsic motivationwas found to have a greater mediating effect thanaffective commitment.