bluuebunny/crossref_metadata_2025 huggingface dataset:
SeatmateVR: Proxemic Cues for Close Bystander-Awareness in Virtual Reality
Authors: Li Jingyi , Park Hyerim , Welsch Robin , Mayer Sven , Butz Andreas
Published: November 2023

Prior research explored ways to alert virtual reality users of bystanders entering the play area from afar. However, in confined social settings like sharing a couch with seatmates, bystanders' proxemic cues, such as distance, are limited during interruptions, posing challenges for proxemic-aware systems. To address this, we investigated three visualizations, using a 2D animoji, a fully-rendered avatar, and their combination, to gradually share bystanders' orientation and location during interruptions. In a user study (N=22), participants played virtual reality games while responding to questions from their seatmates. We found that the avatar preserved game experiences yet did not support the fast identification of seatmates as the animoji did. Instead, users preferred the mixed visualization, where they found the seatmate's orientation cues instantly in their view and were gradually guided to the person's actual location. We discuss implications for fine-grained proxemic-aware virtual reality systems to support interaction in constrained social spaces.
Interactive 3D Annotation of Objects in Moving Videos from Sparse Multi-view Frames
Authors: Oomori Kotaro , Kawabe Wataru , Matulic Fabrice , Igarashi Takeo , Higuchi Keita
Published: November 2023

Segmenting and determining the 3D bounding boxes of objects of interest in RGB videos is an important task for a variety of applications such as augmented reality, navigation, and robotics. Supervised machine learning techniques are commonly used for this, but they need training datasets: sets of images with associated 3D bounding boxes manually defined by human annotators using a labelling tool. However, precisely placing 3D bounding boxes can be difficult using conventional 3D manipulation tools on a 2D interface. To alleviate that burden, we propose a novel technique with which 3D bounding boxes can be created by simply drawing 2D bounding rectangles on multiple frames of a video sequence showing the object from different angles. The method uses reconstructed dense 3D point clouds from the video and computes tightly fitting 3D bounding boxes of desired objects selected by back-projecting the 2D rectangles. We show concrete application scenarios of our interface, including training dataset creation and editing 3D spaces and videos. An evaluation comparing our technique with a conventional 3D annotation tool shows that our method results in higher accuracy. We also confirm that the bounding boxes created with our interface have a lower variance, likely yielding more consistent labels and datasets.
WorldPoint: Finger Pointing as a Rapid and Natural Trigger for In-the-Wild Mobile Interactions
Authors: Kim Daehwa , Mollyn Vimal , Harrison Chris
Published: November 2023

Pointing with one's finger is a natural and rapid way to denote an area or object of interest. It is routinely used in human-human interaction to increase both the speed and accuracy of communication, but it is rarely utilized in human-computer interactions. In this work, we use the recent inclusion of wide-angle, rear-facing smartphone cameras, along with hardware-accelerated machine learning, to enable real-time, infrastructure-free, finger-pointing interactions on today's mobile phones. We envision users raising their hands to point in front of their phones as a "wake gesture". This can then be coupled with a voice command to trigger advanced functionality. For example, while composing an email, a user can point at a document on a table and say "attach". Our interaction technique requires no navigation away from the current app and is both faster and more privacy-preserving than the current method of taking a photo.
UbiSurface: A Robotic Touch Surface for Supporting Mid-air Planar Interactions in Room-Scale VR
Authors: Gomi Ryota , Takashima Kazuki , Onishi Yuki , Fujita Kazuyuki , Kitamura Yoshifumi
Published: November 2023

Room-scale VR has been considered an alternative to physical office workspaces. For office activities, users frequently require planar input methods, such as typing or handwriting, to quickly record annotations to virtual content. However, current off-the-shelf VR HMD setups rely on mid-air interactions, which can cause arm fatigue and decrease input accuracy. To address this issue, we propose UbiSurface, a robotic touch surface that can automatically reposition itself to physically present a virtual planar input surface (VR whiteboard, VR canvas, etc.) to users and to permit them to achieve accurate and fatigue-less input while walking around a virtual room. We design and implement a prototype of UbiSurface that can dynamically change a canvas-sized touch surface's position, height, and pitch and yaw angles to adapt to virtual surfaces spatially arranged at various locations and angles around a virtual room. We then conduct studies to validate its technical performance and examine how UbiSurface facilitates the user's primary mid-air planar interactions, such as painting and writing in a room-scale VR setup. Our results indicate that this system reduces arm fatigue and increases input accuracy, especially for writing tasks. We then discuss the potential benefits and challenges of robotic touch devices for future room-scale VR setups.
A New Design Paradigm for Polymorphic Backscatter Radios
Authors: Guo Xiuzhen , He Yuan , Liu Yunhao , Shangguan Longfei
Published: November 2023

The proliferation of Internet of Things (IoT) applications brings about the increasingly dense deployments of various wireless devices (e.g., Wi-Fi, ZigBee, Bluetooth, LoRa, etc.). The coexistence of heterogeneous wireless devices puts forward more stringent requirements for the adaptability and flexibility of the backscatter design [1]. In order to integrate seamlessly into heterogeneous wireless networks, the backscatter radio should be able to interplay directly with different technologies while maintaining ultra-low power consumption [2].
Acoustic Localization of Drones in Precise Landing: The Research and Practice with MicNest
Authors: Wang Weiguo , He Yuan , Mottola Luca , Li Shuai , Sun Yimiao , Li Jinming , Jing Hua , Wang Ting , Wang Yulei
Published: November 2023

Delivery drones have the potential to revolutionize transportation and distribution of goods. With their autonomous navigation capabilities, they offer an efficient solution to bypass the challenges posed by complex urban traffic and enable instant package delivery. Many industrial firms are actively exploring the commercial feasibility of instant drone deliveries. Meituan, one of the largest companies in this area, devised a systematic approach to instant delivery using drones. The process begins with loading the package onto the drone, which then takes off, ascends to cruising altitude, and sets a direct course towards the designated destination. Typically, this destination is a Meituan-operated self-collection station located near the customer.
Local field potential responses associated with perceptual filling-in at blind spot in macaque primary visual cortex
Authors: Saito Harumi , Masaoka Akihiro , Komatsu Hidehiko
Published: November 2023

Two characteristic activities were induced in the blind spot (BS) region in response to the stimulus, causing perceptual filling-in: 1) beta-band LFP responses in the superficial layers and 2) neuronal responses in the deep layers, mainly in layer 5. These data suggest that the feedback signal from the extrastriate areas to the BS region in V1 is involved in perceptual filling-in.
A Phase IIIb, Multicentre, Interventional, Randomised, Placebo‐Controlled Clinical Trial Investigating the Efficacy and Safety of Guselkumab for the Treatment of Nonpustular Palmoplantar Psoriasis (G‐PLUS)
Authors: Passeron Thierry , Carrascosa Jose Manuel , Warren Richard B. , Pinter Andreas , Romanelli Marco , Gorecki Patricia , Efficace Michela , Fakharzadeh Steve , Yang Ya-Wen , Azzabi Ahlem , Jazra Maria , Lemos Katya , Leung Monica , Chen Yanqing , Thaçi Diamant
Published: November 2023

Introduction. Despite the availability of effective biologic therapies for psoriasis, there is no gold‐standard treatment for nonpustular palmoplantar psoriasis (ppPsO). Methods. G‐PLUS, a phase IIIb, double‐blind, placebo‐controlled, multicentre clinical trial, randomised adults with moderate‐to‐severe nonpustular ppPsO and limited plaque psoriasis (Psoriasis Area and Severity Index (PASI) ≥3 but <10) to guselkumab (an interleukin‐23p19 blocker) or placebo. Placebo participants were crossed over to receive guselkumab at week (Wk) 16. The primary efficacy endpoint was the proportion of participants achieving palmoplantar PASI (ppPASI) 75 response at Wk16; clinical, biomarker, and quality‐of‐life endpoints were assessed through Wk48 and safety through Wk56. Results. At Wk16, ppPASI75 response was achieved by 35.9% of the guselkumab participants compared with 28.2% in the placebo group, resulting in a 7.7% difference in response rates (95% confidence interval: −11.5 and 24.7), which was not statistically significant (p = 0.533). More pronounced numerical improvements favouring guselkumab were observed for more stringent efficacy endpoints, such as Wk16 palmoplantar Investigator’s Global Assessment (ppIGA) 0/1 response (guselkumab 34.6% vs. placebo 15.4%). Through Wk48, further improvements were observed in ppPASI75 response (55.1% and 64.1%) and ppIGA 0/1 response (42.3% and 48.7%) for the guselkumab and placebo‐crossover groups, respectively. Dermatology Life Quality Index responses showed comparable trends at both timepoints. Safety and pharmacodynamic findings were consistent with the established profile for guselkumab. Serum biomarker levels were significantly reduced with guselkumab and correlated with the baseline PASI score but not the ppPASI score. Conclusion. Although the primary endpoint was not met, analysis of stringent secondary endpoints and post hoc analyses showed numerical improvements favouring guselkumab at Wk16. There were no new safety signals. Further studies are warranted to better understand the impact of guselkumab treatment in patients with ppPsO. This trial is registered with NCT03998683.
Supp. Figure 3 from Parkin Deficiency Suppresses Antigen Presentation to Promote Tumor Immune Evasion and Immunotherapy Resistance
Authors: Perales-Linares Renzo , Leli Nektaria Maria , Mohei Hesham , Beghi Silvia , Rivera Osvaldo D. , Kostopoulos Nektarios , Giglio Andrea , George Subin S. , Uribe-Herranz Mireia , Costabile Francesca , Pierini Stefano , Pustylnikov Sergei , Skoufos Giorgos , Barash Yoseph , Hatzigeorgiou Artemis G. , Koumenis Constantinos , Maity Amit , Lotze Michael T. , Facciabene Andrea
Published: November 2023

Figure S3
Supplementary Methods from Matrix Stiffness Triggers Lipid Metabolic Cross-talk between Tumor and Stromal Cells to Mediate Bevacizumab Resistance in Colorectal Cancer Liver Metastases
Authors: Zheng Yannan , Zhou Rui , Cai Jianan , Yang Nanyan , Wen Zhaowei , Zhang Zhihua , Sun Huiying , Huang Genjie , Guan Yijin , Huang Na , Shi Min , Liao Yulin , Bin Jianping , Liao Wangjun
Published: November 2023

Supplementary Methods
Table S6 from Cross-talk between Myeloid and B Cells Shapes the Distinct Microenvironments of Primary and Secondary Liver Cancer
Authors: Chen Zhihang , Zhang Guopei , Ren Xiaoxue , Yao Zhijia , Zhou Qian , Ren Xuxin , Chen Shuling , Xu Lixia , Sun Kaiyu , Zeng Qianwen , Kuang Ming , Kuang Dong-Ming , Peng Sui
Published: November 2023

Table S6
Figure S5 from Cross-talk between Myeloid and B Cells Shapes the Distinct Microenvironments of Primary and Secondary Liver Cancer
Authors: Chen Zhihang , Zhang Guopei , Ren Xiaoxue , Yao Zhijia , Zhou Qian , Ren Xuxin , Chen Shuling , Xu Lixia , Sun Kaiyu , Zeng Qianwen , Kuang Ming , Kuang Dong-Ming , Peng Sui
Published: November 2023

Figure S5
Data from Targeting BCL6 in gastrointestinal stromal tumor promotes p53-mediated apoptosis to enhance the antitumor activity of imatinib
Authors: Zeng Xiangyu , Zhao Fei , Jia Jie , Ma Xianxiong , Jiang Qi , Zhang Ruizhi , Li Chengguo , Wang Tao , Liu Weizhen , Hao Yalan , Tao Kaixiong , Lou Zhenkun , Zhang Peng
Published: November 2023

Abstract
Imatinib mesylate (IM) has revolutionized the treatment of gastrointestinal stromal tumor (GIST). However, most patients inevitably acquire IM resistance. Second- and third-line treatments exhibit modest clinical benefits with a median time to disease progression of 4-6 months, highlighting the urgency for novel therapeutic approaches. Here, we report that the expression of BCL6, a known oncogenic driver and transcriptional repressor, was significantly induced in GIST cells following IM treatment. Elevated BCL6 levels suppressed apoptosis and contributed to IM resistance. Mechanistically, BCL6 recruited SIRT1 to the TP53 promoter to modulate histone acetylation and transcriptionally repress TP53 expression. The reduction in p53 subsequently attenuated cell apoptosis and promoted tolerance of GIST cells to IM. Concordantly, treatment of GIST cells showing high BCL6 expression with a BCL6 inhibitor, BI-3802, conferred IM sensitivity. Furthermore, BI-3802 showed striking synergy with IM in IM-responsive and IM-resistant GIST cells in vitro and in vivo. Thus, these findings reveal a role for BCL6 in IM resistance and suggest that a combination of BCL6 inhibitors and IM could be a potentially effective treatment for GIST.
Data from Bi-allelic Dicer1 mutations in the gynecologic tract of mice drive lineage-specific development of DICER1 syndrome-associated cancer
Authors: Wang Yemin , Chen Shary Yuting , Ta Monica , Senz Janine , Tao Lan Valerie. , Thornton Shelby , Tamvada Nirupama , Yang Winnie , Moscovitz Yana , Li Eunice , Guo Jingjie , Shen Cindy , Douglas J. Maxwell , El-Naggar Amal M. , Kommoss Felix K. F. , Underhill T. Michael , Singh Naveena , Gilks C. Blake , Morin Gregg B. , Huntsman David G.
Published: November 2023

Abstract
DICER1 is an RNase III enzyme essential for microRNA (miRNA) biogenesis through cleaving pre-miRNA hairpins. Germline loss-of-function DICER1 mutations underlie the development of DICER1 syndrome, a rare genetic disorder that predisposes children to cancer development in organs such as lung, gynecologic tract, kidney, and brain. Unlike classical tumor suppressors, the somatic “second hit” in DICER1 syndrome-associated cancers does not fully inactivate DICER1 but impairs its RNase IIIb activity only, suggesting a noncanonical two-hit hypothesis. Here, we developed a genetically engineered conditional compound heterozygous Dicer1 mutant mouse strain that fully recapitulates the bi-allelic DICER1 mutations in DICER1 syndrome-associated human cancers. Crossing this tool strain with tissue-specific Cre strains that activate Dicer1 mutations in gynecologic tract cells at two distinct developmental stages revealed that embryonic bi-allelic Dicer1 mutations caused infertility in females by disrupting oviduct and endometrium development and ultimately drove cancer development. These multicystic tubal and intra-uterine tumors histologically resembled a subset of DICER1 syndrome-associated human cancers. Molecular analysis uncovered accumulation of additional oncogenic events (e.g. aberrant p53 expression, Kras mutation, and Myc activation) in murine Dicer1 mutant tumors and validated miRNA biogenesis defects in 5P miRNA strand production, of which loss of let-7 family miRNAs was identified as a putative key player in transcriptomic rewiring and tumor development. Thus, this DICER1 syndrome-associated cancer model recapitulates the biology of human cancer and provides a unique tool for future investigation and therapeutic development.
Epigenetic Regulators Open the Door to SCLC Plasticity
Authors: Weber Margaret C. , Izzo Luke T. , Oliver Trudy G.
Published: November 2023

Small-cell lung cancer (SCLC) is a neuroendocrine tumor type with limited treatment options and poor prognosis. SCLC comprises multiple molecular subtypes that are defined by the expression of the lineage-related transcription factors ASCL1, NEUROD1, POU2F3, and more controversially, YAP1. SCLC exhibits remarkable plasticity with the capacity to transition between molecular states; because these states are associated with unique therapeutic susceptibilities, SCLC has been likened to a moving therapeutic target. While MYC's role in driving the ASCL1-to-NEUROD1 (A-to-N) transition is established, additional mechanisms governing SCLC plasticity remain largely obscure. A recent study by Duplaquet and colleagues, published in Nature Cell Biology, employs an innovative genetically engineered mouse model of SCLC harboring loss of KDM6A—a histone lysine demethylase mutated in approximately 2% of SCLC cases. KDM6A loss in SCLC alters chromatin accessibility and increases the potential for A-to-N plasticity in vivo. Through characterization of the epigenetic landscape, Duplaquet and colleagues identified histone methylation as a key regulator of SCLC plasticity. These findings provide not only a new model system for studying SCLC plasticity, but also identify new epigenetic mechanisms involved, which will ultimately be critical for designing more effective therapies.
Adiposity, Weight Change, and Urinary Melatonin Levels among Men in the Multiethnic Cohort
Authors: Chowdhury-Paulino Ilkania M. , Vaselkiv Jane B. , Cheng Iona , Schernhammer Eva S. , Lin Zhike , Haiman Christopher A. , Le Marchand Loïc , Valdimarsdóttir Unnur , Wilkens Lynne R. , Markt Sarah C. , Mucci Lorelei A.
Published: November 2023

Background:

Low levels of 6-sulfatoxymelatonin, the primary urinary metabolite of melatonin, have been linked to cancer and cardiometabolic outcomes in White and female populations.

Methods:

We examined the association between adulthood adiposity and 6-sulfatoxymelatonin levels in a racially and ethnically diverse population. Our study included 4,078 men in the Multiethnic Cohort with adiposity measurements at enrollment (1993–1996) and biomarkers measured in urines collected in 1995 and 2005. Multivariable linear regression models were used to estimate the percent change in 6-sulfatoxymelatonin levels and 95% confidence intervals (CI). Associations were examined separately by racial/ethnic group.

Results:

The prevalence of obesity varied by race and ethnicity, from 10% for Japanese American men to 34% for Native Hawaiian men. Compared with men with normal body mass index (BMI), men who were overweight (−7.8%; 95% CI, −11.9 to −3.5%) and obese (−18.1%; 95% CI, −23.2 to −12.6%) had significantly lower 6-sulfatoxymelatonin levels adjusting for potential confounding factors. Increasing weight gain in adulthood was also associated with lower 6-sulfatoxymelatonin (Ptrend < 0.0001). The inverse associations for BMI and weight change were qualitatively similar across racial and ethnic groups.

Conclusions:

Obesity is inversely associated with melatonin in a racially diverse population. This finding is relevant given higher rates of obesity among Black, Native Hawaiian, and Latino men, as well as potential racial and ethnic differences in circadian function.

Impact:

Melatonin may be a relevant biomarker among obesity-associated malignancies and could shed light on a potential mechanism of cancer disparities.
Enhancing Mammography and Empowering Solutions for Breast Cancer Disparities
Authors: Tehranifar Parisa , Bertrand Kimberly A.
Published: November 2023

Mammography enables early detection of breast cancer, a critical factor in improving treatment outcomes and breast cancer mortality. Yet, not all women benefit equally, and striking racial disparities in breast cancer mortality persist, with Black women 40% more likely to die from breast cancer compared with non-Hispanic White women. The current issue of Cancer Epidemiology, Biomarkers & Prevention presents three informative reports revealing racial and ethnic variations in mammography's performance in risk stratification, detection, and surveillance. The performance dynamics of mammography across different racial and ethnic groups highlight the urgency for additional research and innovative interventions to ensure equitable breast cancer control. We emphasize a pressing need for a comprehensive evaluation of multilevel influences on the performance and implementation of mammography in racially and ethnically diverse populations, complemented by equally urgent efforts to address factors influencing the risk of aggressive tumor subtypes and timely and effective treatment delivery.

See related articles by Kerlikowske et al., p. 1524, Hubbard et al., p. 1531, Nyante et al., p. 1542
Data from Targeted Nanofitin-drug conjugates achieve efficient tumor delivery and therapeutic effect in an EGFR-positive mouse xenograft model
Authors: Huet Simon , Zeisser Labouebe Magali , Castro Rute , Jacquot Perrine , Pedrault Jessy , Viollet Sébastien , Van Simaeys Gaetan , Doumont Gilles , Larbanoix Lionel , Zindy Egor , Cunha António E. , Scapozza Leonardo , Cinier Mathieu
Published: November 2023

Abstract
Adjusting the molecular size, the valency and the pharmacokinetics of drug conjugates are as many leverages to improve their therapeutic window, notably by affecting tumor penetration, renal clearance and short systemic exposure. In that regard, small tumor-targeting ligands are gaining attention. In this study, we demonstrate the benefits of the small Nanofitin alternative scaffolds (7 kDa) as selective tumor-targeting modules for the generation of drug conjugates, focusing on Nanofitins B10 and D8 directed against the Epithelial Growth Factor Receptor (EGFR). Owing to their small size and monovalent format, the two Nanofitins displayed a fast and deep tumor penetration in EGFR-positive A431 xenografts in BALB/c nude mice after intravenous administration, yielding to a targeting of respectively 67.9%±14.1 and 98.9%±0.7 of the tumor cells as demonstrated by immunohistochemistry. Conjugation with the monomethyl auristatin E toxin provided homogeneous Nanofitin-drug conjugates, with an overall yield of ≥97%, for in vivo assessment in a curative xenograft model using bioluminescent, EGFR-positive, A431 cells in BALB/c nude mice. Internalization was found critical for efficient release of the toxin. Hence, the intravenous administration of the D8-based construct showed significant anti-tumor effect in vivo as determined by monitoring tumor volumes and bioluminescence levels over 2 months.
Data from Efficacy and safety of glycosphingolipid SSEA-4 targeting CAR-T cells
in an ovarian carcinoma model
Authors: Monzo Hector J. , Kalander Kerttu , Hyytiäinen Marko M. , Elbasani Endrit , Wall Johanna , Moyano-Galceran Lidia , Tanjore Ramanathan Jayendrakishore , Jukonen Joonas J.J. , Laakkonen Pirjo , Ristimäki Ari , Carlson Joseph W. , Lehti Kaisa , Salehi Sahar , Puolakkainen Pauli , Haglund Caj , Seppänen Hanna , Leppä Sirpa , Ojala Päivi M.
Published: November 2023

Abstract
Chimeric antigen receptor (CAR) T-cell immunotherapies for solid tumors face critical challenges such as heterogeneous antigen expression. We characterized SSEA-4 cell-surface glycolipid as a target for CAR-T cell therapy. SSEA-4 is mainly expressed during embryogenesis but is also found in several cancer types making it an attractive tumor-associated antigen. Anti-SSEA-4 CAR-T cells were generated and assessed pre-clinically in vitro and in vivo for anti-tumor response and safety. SSEA-4 CAR-T cells effectively eliminated SSEA-4 positive cells in all the tested cancer cell lines whereas SSEA-4 negative cells lines were not targeted. In vivo efficacy and safety studies using NSG mice and the high-grade serous ovarian cancer cell line OVCAR4 demonstrated a remarkable and specific anti-tumor response at all the CAR-T cell doses used. At high T cell doses, CAR-T cell-treated mice showed signs of health deterioration after a follow-up period. However, the severity of toxicity was reduced with a delayed onset when lower CAR-T cell doses were used. Our data demonstrate the efficacy of anti-SSEA-4 CAR-T therapy; however, safety strategies, such as dose-limiting and/or equipping CAR-T cells with combinatorial antigen recognition should be implemented for its potential clinical translation.
Improving Intracellular Delivery of an Antibody–Drug Conjugate Targeting Carcinoembryonic Antigen Increases Efficacy at Clinically Relevant Doses In Vivo
Authors: Nessler Ian , Rubahamya Baron , Kopp Anna , Hofsess Scott , Cardillo Thomas M. , Sathyanarayan Nalini , Donnell Jennifer , Govindan Serengulam V. , Thurber Greg M.
Published: November 2023

Solid tumor antibody–drug conjugates (ADC) have experienced more clinical success in the last 5 years than the previous 18-year span since the first ADC approval in 2000. While recent advances in protein engineering, linker design, and payload variations have played a role in this success, high expression and readily internalized targets have also been crucial to solid tumor therapy. However, these factors are also paradoxically connected to poor tissue penetration and lower efficacy. Previous work shows that potent ADCs can benefit from slower internalization under subsaturating doses to improve tissue penetration and increase tumor response. In contrast, faster internalization is predicted to increase efficacy under higher, tumor saturating doses. In this work, the intracellular delivery of SN-38 conjugated to an anti-carcinoembryonic antigen (anti-CEA) antibody (Ab) is increased by coadministering a noncompeting (cross-linking) anti-CEA Ab to improve efficacy in a colorectal carcinoma animal model. The SN-38 payload enables broad tumor saturation with clinically-tolerable doses, and under these saturating conditions, using a second CEA receptor cross-linking Ab yields faster internalization, which increases tumor killing efficacy. Our spheroid results show indirect bystander killing can also occur, but the more efficient direct cell killing from targeted intracellular payload release drives a greater tumor response. These results provide a strategy to increase therapeutic effectiveness with improved intracellular delivery under tumor saturating doses with the potential to expand the ADC target repertoire.
Rutgers Cancer Institute of New Jersey's Community Outreach and Engagement Approach to Cancer Prevention
Authors: Kinney Anita Y. , Stroup Antoinette M. , Scharf Sarah , Libutti Steven K.
Published: November 2023

Rutgers Cancer Institute of New Jersey (New Brunswick, NJ) is committed to providing cancer prevention education, outreach, and clinical services in our catchment area (CA). Our approach to cancer prevention includes ongoing surveillance to better understand the CA cancer burden and opportunities for intervention, leveraging community partnerships, and vigorously engaging diverse communities to understand and address their needs. This approach considers individual, sociocultural, environmental, biologic, system, and policy-level factors with an equity lens. Rutgers Cancer Institute has had substantial impact on cancer prevention (risk reduction, screening, and early detection) over the past five years, including the development of a CA data dashboard advancing implementation of evidence-based cancer control actions by leveraging 357 healthcare and community partners (with 522 partner sites). Furthermore, we provided professional education (attendance 19,397), technical assistance to community organizations (1,875 support sessions), educational outreach for community members (87,000+ through direct education), facilitated access to preventive services (e.g., 60,000+ screenings resulting in the detection of >2,000 malignant and premalignant lesions), contributed to advances in health policy and population-level improvements in risk reduction behaviors, screening, and incidence. With longer-term data, we will assess the impact of our cancer prevention efforts on cancer incidence, downward shifts in stage at diagnosis, mortality, and disparities.
Invasive Cystic Hypersecretory Ductal Carcinoma of Breast: Challenges in Diagnosis and Management
Authors: Alshaibani Noof , Chandramohan Janaki Krithika , Khairi Sara Salah , Al-Hashimi Fatima , Aljawder Aysha Anwar
Published: November 2023

Cystic hypersecretory lesions of the breast are a spectrum of conditions ranging from cystic hypersecretory hyperplasia with atypia and invasive cystic hypersecretory carcinoma (CHC). It is a subtype of ductal carcinoma of the breast. The tumour is very infrequent and hence, extensive literature is limited. This culminates in the fact that it does not feature as part of the WHO classification of breast tumours. However, a good knowledge about its distinct pathological features can avert misdiagnosis and help differentiate CHC from other conditions. Thus far, only 22 cases of invasive CHC have been reported, of which 3 were microinvasive. Only 7 cases of axillary lymph node metastasis have been documented. We report a case of invasive CHC of the breast that was metastatic to the axilla and refractory to neoadjuvant chemotherapy. Our case report aims to add to the literature on the disease, aiming to support large-scale studies in the future in order to elaborate on its clinical and biological characteristics.
Robot-Assisted Extraperitoneal Radical Prostatectomy for Giant Multilocular Prostatic Cystadenoma: A Case Report and Literature Review
Authors: Scarcia Marcello , Moretto Stefano , Zazzara Michele , Alba Stefano , Fiorentino Alba , Ciampi Luigia , Ludovico Elena , Calbi Roberto , Ludovico Giuseppe M.
Published: November 2023

A 48-year-old man with a medical history of hypertension and no family history of prostate cancer presented with abdominal distension, lower abdominal pain, and lower urinary symptoms. Physical examination revealed a palpable mass in the lower abdomen, and a digital rectal examination detected a firm mass on the anterior side of the rectum. Laboratory tests showed an elevated PSA level (7.9 ng/mL). Imaging studies indicated a solid mass connected to the prostate’s posterior and rectum’s anterior walls, along with bladder compression. Transperitoneal biopsy and histological analysis led to a diagnosis of a stromal tumor with uncertain potential malignancy. Considering the absence of apparent malignancy signs and the smooth outer wall of the tumor, the patient underwent, for the first time in the literature, a robot-assisted radical extraperitoneal prostatectomy for complete macroscopic resection. The surgery involved excision of the bulky pelvic mass, preservation of the urethra, and anatomical reconstruction. The postoperative course was uneventful, and we discharged the patient with no complications. The pathological examination documented the diagnosis of multilocular prostatic cystadenoma. Post-surgery follow-up examinations, including PSA levels and imaging scans, showed no signs of tumor recurrence. At the 3-, 6-, and 9-month follow-ups, the patient was asymptomatic and had fully recovered, with no urinary or sexual dysfunction reported.
Paulo Freire: aportes a la educación en red, abierta y a distancia más allá de la covid-19: en conmemoración del natalicio de Paulo Freire 1921-2021
Authors:   Universidade de São Paulo. Faculdade de Educação, Gomez Margarita Victoria , Castañeda Manuel Moreno ,   Universidad de Guadalajara - UDG
Published: November 2023

Los tiempos de aislamiento son propicios para pensar en prácticas liberadoras, buscar enseñanzas contenidas en la "Pedagogía de la pregunta" y transformar la educación a distancia en una actividad dialógica, renovadora y esperanzadora. Este libro conmemora a Paulo Freire, en el año de su natalicio; para enfrentar la covid-19, valora las memorias, los diferentes saberes y las múltiples acciones culturales. Fomentar diálogos, investigar, cuidar de los afectos, hacer intercambios y sueños posibles, es lo que este libro despierta en el lector en tiempos de pademia. ¡Disfrute de la Lectura! ¡Recree el lenguaje! ¡Reinvente las prácticas dialógicas!
Pregnancy—An Ideal Period to Identify Women at Risk for Chronic Hypertension
Authors: Charakida Marietta , Wright Alan , Magee Laura A. , Syngelaki Argyro , von Dadelszen Peter , Akolekar Ranjit , Wright David , Nicolaides Kypros H.
Published: November 2023

BACKGROUND:

Cardiovascular disease is the leading cause of mortality in women. Pregnancy is an ideal period to implement cardiovascular prevention strategies as women seek medical help. We aimed to develop a predictive model to identify women at increased risk for chronic hypertension (CH) based on information collected in the index pregnancy.

METHODS:

Cohort of 26 511 women seen in 2 consecutive pregnancies. Included were women without CH, with information on maternal characteristics and blood pressure at 11 to 13 weeks’ gestation, and the development of preeclampsia or gestational hypertension (GH) in the index pregnancy. Logistic regression models were fitted for the prediction of the development of future CH by the 20th week of the subsequent pregnancy. The performance of screening and risk calibration of the model were assessed.

RESULTS:

In this study 1560 (5.9%) women developed preeclampsia or GH (index pregnancy), and 215 (0.8%) developed future CH, with a median of 3.0 years later. Predictors of development of future CH were maternal age, weight, and blood pressure; Black and South Asian ethnicity; family history of preeclampsia; parity; and development of preeclampsia or GH. Preeclampsia or GH detected 52.1% (45.2%–58.9%) of future CH. At a screen-positive rate of 10%, a model including maternal characteristics, early pregnancy blood pressure, and development of preeclampsia or GH detected 73.5% (67.1–79.3) of future CH.

CONCLUSIONS:

Early pregnancy maternal characteristics, blood pressure, and development of preeclampsia or GH identify three-fourths of women at risk for future CH. Our results offer an important preventative strategy for identifying women at increased risk of future CH, which is applicable worldwide.
Effect of Smoking Cessation on the Risk of Subarachnoid Hemorrhage: A Nested Case-Control Study in Korean Men
Authors: Ok Taedong , Jeon Jimin , Heo Seok-Jae , Kim Jinkwon
Published: November 2023

BACKGROUND:

Smoking is a well-established risk factor for subarachnoid hemorrhage (SAH), and current smokers have an increased risk of SAH. However, there are insufficient data on whether smoking cessation in current smokers reduces the risk of SAH.

METHODS:

A nested case-control study was conducted based on the National Health Insurance Service-National Health Screening Cohort, which comprises nationwide health claims data and a national health screening program in Korea (2002–2019). We constructed a cohort of current male smokers without a history of stroke at the baseline health screening (2002–2003). From this cohort, cases were defined as individuals who experienced a nontraumatic SAH during the follow-up period up to 2019. Five controls were matched to each case using incidence density sampling. Smoking status (continuation or cessation) before the occurrence of SAH was evaluated using the repeated national health screening program. We conducted a multivariable conditional logistic regression analysis, adjusting for alcohol consumption, physical activity, body mass index, systolic blood pressure, and fasting blood glucose levels, to evaluate the association between SAH risk and smoking cessation.

RESULTS:

At baseline, there were 112 142 current male smokers. After excluding individuals with prior stroke or insufficient data, the cohort consisted of 105 223 eligible participants (mean age, 50.3±8.5 years). Among them, we identified 318 cases of SAH and 1590 matched controls. Those who quit smoking had a significantly lower risk of SAH compared with current smokers (adjusted odds ratio, 0.55 [95% CI, 0.41–0.73]). The risk of SAH decreased with a longer period of smoking cessation. The risk reduction with smoking cessation was consistent even among prior heavy smokers.

CONCLUSIONS:

Smoking cessation in current male smokers reduced the risk of SAH, and the risk reduction was greater as the cessation period increased. These findings warrant intensive efforts to encourage smokers, even heavy smokers, to quit.
Spectral dynamic causal modeling: A didactic introduction and its relationship with functional connectivity
Authors: Novelli Leonardo , Friston Karl , Razi Adeel
Published: November 2023

We present a didactic introduction to spectral dynamic causal modeling (DCM), a Bayesian state-space modeling approach used to infer effective connectivity from noninvasive neuroimaging data. Spectral DCM is currently the most widely applied DCM variant for resting-state functional MRI analysis. Our aim is to explain its technical foundations to an audience with limited expertise in state-space modeling and spectral data analysis. Particular attention will be paid to cross-spectral density, which is the most distinctive feature of spectral DCM and is closely related to functional connectivity, as measured by (zero-lag) Pearson correlations. In fact, the model parameters estimated by spectral DCM are those that best reproduce the cross-correlations between all measurements—at all time lags—including the zero-lag correlations that are usually interpreted as functional connectivity. We derive the functional connectivity matrix from the model equations and show how changing a single effective connectivity parameter can affect all pairwise correlations. To complicate matters, the pairs of brain regions showing the largest changes in functional connectivity do not necessarily coincide with those presenting the largest changes in effective connectivity. We discuss the implications and conclude with a comprehensive summary of the assumptions and limitations of spectral DCM.
Kinesiophobia and Associated Factors in Patients With Myocardial Infarction
Authors: Yakut Ozdemir Hazal , Ozalevli Sevgi , Felekoglu Elvan , Baskurt Ahmet Anıl , Dursun Huseyin
Published: November 2023

Kinesiophobia is a well-known barrier to positive clinical outcomes among patients with various diseases, but there remain few comprehensive studies of kinesiophobia among patients with myocardial infarction (MI). In this cross-sectional study, we investigated the presence of kinesiophobia and its relationship with clinical outcomes among 42 patients with MI who completed the Tampa Scale of Kinesiophobia Swedish Version for Heart (TSK-SV Heart) the International Physical Activity Questionnaire-Short Form (IPAQ-SF), the Six-Minute Walk Test (6MWT), the Hospital Anxiety and Depression Scale (HADS), the modified Medical Research Council (mMRC) Dyspnea Scale, the Charlson Comorbidity Index (CCI), and the MacNew Heart Disease Health-Related Quality of Life Questionnaire. The participants’ mean TSK-SV Heart score was 39.24 ( SD = 6.65), and 71.4% of these patients reported a high level of kinesiophobia. The TSK-SV Heart score demonstrated a strong correlation with the IPAQ-SF, 6MWT walking distance, and mMRC score ( p < .001), and a moderate correlation with the HADS, CCI, and MacNew Heart Disease HRQoL ( p < .05). Patients with a high level of kinesiophobia had lower IPAQ-SF, 6MWT walking distance, and HRQoL and higher mMRC, CCI, and HADS scores than patients with low levels of kinesiophobia ( p < .05). Kinesiophobia was common and represented a considerable risk factor for physical-psychosocial dysfunctions in these patients with MI. To maintain functional independence and to increase physical activity level, clinicians should consider kinesiophobia from early to late-stage disease and should add a treatment focus that seeks to eliminate kinesiophobia in cardiac rehabilitation programs.
A spatial perspective on renewable energy optimization: Case study of southern Tunisia Using GIS and multicriteria decision making
Authors: Rekik Sassi , El Alimi Souheil
Published: November 2023

Renewable energy systems have emerged as a viable option to mitigate the environmental impacts of traditional fossil fuels. However, the intermittent nature of these renewables, such as solar and wind, makes it challenging to ensure a stable energy supply using only one type. Therefore, combining more than a single technology offers significant advantages in addressing the limitations associated with each individual system. Nevertheless, developing these systems requires substantial financial investments, making it crucial to identify the most suitable locations prior to installing them. In this article, the prime objective was to propose a preliminary evaluation of land suitability for constructing solar and wind hybrid facilities (PV–wind, PV–CSP, and CS–wind) in Tataouine, southern Tunisia. To this end, a GIS-based MCDA methodology was developed based on an extensive literature review and experts’ feedback while considering climate, topography, accessibility, and environmental factors. The results obtained revealed that the optimal area for a CSP–PV hybrid system is about 793 km2, indicating that this combination has the highest potential in terms of available resources and compatibility. On the other hand, well-suited locations for hosting CSP–wind and PV–wind systems covered areas of 412 and 333 km2, respectively. Such specific locations are capable of generating an annual technical potential of 316.169, 91.252, and 62.970 TWh for CSP–PV, CSP–wind, and PV–wind, respectively. Interestingly, comprising almost all of the most appropriate sites, Remada and Dhiba stand as the ideal locations for accommodating such hybrid systems. Considering this outcome, Tataouine can position itself as a model for renewable energy adoption in Tunisia. Therefore, it is imperative for policymakers, investors, and local communities to collaborate and embrace these hybrid systems to capitalize on this immense potential and pave the way for a greener and more prosperous future.
Patient interest in acupuncture for smoking cessation: a survey
Authors: Sicker Kelsey M , Secic Michelle , Graham Anna , Auciello Stephen E
Published: November 2023

Background/Objective:

Tobacco use remains the leading cause of preventable death in the United States. The most widely available treatment options to assist patients in smoking cessation are limited by side effects and moderate efficacy at best. Acupuncture may be an effective option for smoking cessation. The goal of this study was to establish the need for and interest in acupuncture therapy to potentially assist with smoking cessation from a patient perspective.

Methods:

We conducted a cross-sectional survey study among patients aged 18 years or older whose medical record reported current tobacco use with English as their preferred language. REDCap surveys were administered to patients during office visits and included questions regarding opinions and use of all treatments available for smoking cessation (including acupuncture) as well as perceived barriers to acupuncture treatment.

Results:

A total of 57 surveys were distributed, and 42 (74%) were completed. Most patients reported previous attempts at quitting (76%) and had tried a variety of treatments including nicotine replacement (45%), Chantix (varenicline; 23%), Wellbutrin (bupriopion; 19%), “cold turkey” (65%) and hypnosis (3%). No respondents reported having tried acupuncture for smoking cessation.

Conclusion:

When comparing treatment options, patients reported more interest in acupuncture than other treatment options with a statistically significant difference in the level of interest between acupuncture and bupropion. All barriers (cost, time and effectiveness) were equally rated on a Likert-type scale with a median of 50 on a 101-point scale.
Venous Thromboembolism Risk Assessment in Hospitalized Cancer Patients: A Single Center Study
Authors: Rayamajhi Supratik , Shrotriya Shiva , Rai Manoj , Dhakal Prajwal , Basnet Nishraj , Sharma Mukta , Lupi Alexa , Gardiner Joseph
Published: November 2023

This study aimed to identify predictors of venous thromboembolism (VTE) in hospitalized cancer patients and develop a predictive model using demographic, clinical, and laboratory data. Our analysis showed that patient groups categorized under a very high risk, and high risk, patients with low hemoglobin levels and renal disease were at a significantly increased risk of developing VTE. We developed a VTE risk-assessment model (RAM) with moderate discriminatory performance, high specificity, and negative predictive value, indicating its potential utility in identifying patients without VTE risk. However, the model's positive predictive value and sensitivity were low due to the low prevalence of VTE within the analyzed population. Future studies are needed to analyze additional predictive factors, and to validate the effectiveness of our VTE RAM to safely rule out VTE, compare it with other VTE RAMs in hospitalized cancer patients, and address any limitations of our study.
My Journal and a Felt Sense: Tami’s Lineage and Legacy
Authors: Mapes Meggie
Published: November 2023

This performative essay uses poetry and personal narrative to trace my co-constituted scholarly lineage under scholar/mentor Dr. Tami Spry. To honor her legacy throughout performance studies, I share journal entries from 2009 while taking my first course in performance studies with Dr. Spry in Alnwick, England.
Protesting in the Time of Pandemic: Diagonal Accountability, #KerajaanGagal, and Democratic Regression in Malaysia
Authors: Panneerselvam Ilaiya Barathi , Tayeb Azmil
Published: November 2023

This article argues that there are four conditions that create a conducive political climate allowing civil society and the media to hold the government accountable during the time of pandemic (2020–2021) i.e., the diagonal accountability: 1) the undemocratic formation of the Muhyiddin Yassin's government that lacked public mandate, which in turn made the government unstable and prone to political pressures; 2) the relative freedom of print and online media in reporting negative news concerning the government; 3) civil society's ability to find creative ways around pandemic restrictions to protest; and 4) socio-economic fallout from strict pandemic measures built up public resentment against the government and contributed to its unpopularity. Analyzed through the lens of political process model, and augmented by interviews with protest participants, the four conditions enable civil society and media to take advantage of the unstable political situation, namely in carving up democratic spaces amidst various restrictions imposed by the pandemic.
Determinants of Medical Equipment Alarm Fatigue in Practicing Nurses: A Systematic Review
Authors: Shaoru Chen , Hui Zhi , Su Wu , Ruxin Jiang , Huiyi Zhang , Hongmei Zhang , Hongyan Zhang
Published: November 2023

Objective

This study aimed to systematically evaluate the level of medical equipment alarm fatigue and its influencing factors among clinical nurses.

Methods

PubMed, Embase, CNKI, and Wanfang databases were systematically searched to identify articles on alarm fatigue of clinical nurses published before September 25, 2022. According to the evaluation criteria of prevalence studies recommended by JBI Evidence-Based Health Care Center, the quality of the literature meeting the inclusion criteria was evaluated, and Stata MP17 software was used for meta-analysis.

Results

A total of 14 cross-sectional studies were included, with a total sample of 2,848 nurses. The results showed that the alarm fatigue score of clinical nurses was 21.76 (95% CI [20.27, 23.25]). Subgroup analysis showed that the nurses who worked night shift and had lower professional title had higher alarm fatigue.

Conclusion

The alarm fatigue of clinical nurses was at a moderate level. To reduce the alarm fatigue level of clinical nurses, nursing managers should strengthen the alarm safety awareness of nurses, rationally arrange nurse manpower, carry out training to actively improve the alarm management ability of nurses, and optimize the alarm level and frequency of alarm equipment.