bluuebunny/crossref_metadata_2025 huggingface dataset:
PENGARUH PELATIHAN OLAHRAGA RENANGINTENSITAS SEDANG DAN INTENSITAS TINGGITERHADAP RESPONS SEL ABSORPTIF SEBAGAIPENGABSORPSI HASIL PENCERNAAN PADAUSUS HALUS
Authors: I Nyoman Kanca I Wayan Artanayasa dan
Published: June 2020

Penelitian ini bertujuan untuk mengetahui pengaruhpelatihan olahraga renang dengan intensitas sedang dan intensitastinggi terhadap respons sel absortif sebagai pengabsorpsi hasilproses pencernaan di usus halus.Jenis penelitian tergolong eksperimental laboratoris,menggunakan rancangan ''theseparatesarfTplepretest-posttestamtrolgrcxpdesign". Data dianalisis dengan rumus t-test program SPSS 10.Penelitian menggunakan pelatihan olahraga renang denganintensitas sedang dan intensitas tinggi selama 4 minggu (12 kalipelatihan) pada hewan coba tikus putih jantan jenis wistar, umur± 5 bulan, berat badan 246-278 gram, eksperimen dilakukanmalam hari, pukul 19.30-22.30 WIB, suhu air 28-30° C. Hewancoba sebanyak 80 ekor yang homogen dibagi menjadi 4 kelompoksecara alokasi rwxhn [random asd^vnent) berdasarkan undian, yaitusatu kelompok pretest, satu kelompok kontrol, dan dua kelompokperlakuan (satu kelompok pelatihan olahraga renang denganintensitas sedang, dan satu kelompok pelatihan olahraga renangdengan intensitas tinggi.Hasil penelitian menunjukkan, bahwa (1) pelatihanolahraga renang dengan intensitas sedang dan intensitas tinggidapat meningkatkan respons sel absorptif, detigan nilai I = -73,281,p = 0,000, (2) ada perbedaan pengaruh antara olahraga renangintensitas sedang dengan olahraga intensitas tinggi padapeningkatan respons sel absorptif (t = -0,860 p = 0,393). Dapatdisimpulkan, bahwa (1) pelatihan olahraga ren ang dengan intensitassedang dan intensitas tinggi selama 4 minggu dapat meningkatkanjumlah sel absorptif di usus halus, (2) ada perbedaan antarapelatihan olahraga dengan intensitas sedang dan intensitas tinggipada peningkatan jumlah sel absorptif. Peningkatan jumlah selabsorptif pada pelatihan olahraga renang intensitas sedang lebihsedikit dibanding dengan pelatihan olahrga renang intensitastinggi.Kata kunci: pelatihan, olahraga, sel, usus halus.
KEMAMPUAN MOTORIK KASAR TUNAGRAHITA KELAS DASARMAMPU DIDIK DIUKUR MELALUI DASAR PERMAINAN BOLATANGAN
Authors: Sumaryanti Wulanning Dyah Eka Pradani ,
Published: June 2020

Penelitian ini bertujuan untuk mengetahui berapa besar kemampuan motorik kasaranak tunagrahita kelas dasar mampu didik diukur melalui dasar permainan bola tangandi SLB C Senuko Godean Sleman.Penelitian ini merupakan penelitian deskriptif kuantitatif menggunakan metodesurvei dengan teknik pengambilan datanya menggunakan test. Populasi dalampenelitian ini adalah seluruh siswa tunagrahita SLB C Senuko Godean Sleman yangberjumlah 20 responden, dan seluruh anggota populasi dijadikan subyek penelitian. Ujivaliditas instrumen menggunakan korelasi product moment dan diperoleh hasil 20 soaldinyatakan valid dengan nilai korelasi ≥ r tabel 0.4259 atau probabilitas output SPSS ≤0,05. Uji Reliabilitas Instrumen menggunakan rumus Alpha Cronbach dan memperolehkoefisien reliabilitas antara 0.80-1.00. Teknik analisis data menggunakan analisisdeskriptif yang dituangkan dalam bentuk persentase.Hasil penelitian menunjukkan bahwa kemampuan motorik kasar anak tunagrahitakelas dasar mampu didik diukur melalui dasar permainan bola tangan di SLB CSenuko Godean Sleman mempunyai kategori baik, adapun hasilnya secara keseluruhandiketahui bahwa sebanyak 87.5 % mempunyai motorik kasar baik , dan sebanyak 12.5% mempunyai motorik kasar tidak baik. berdasarkan faktor pembelajaran passing dapatdiketahui bahwa sebanyak 90 % mempunyai motorik kasar baik , dan sebanyak 10 %mempunyai motorik kasar tidak baik. berdasarkan faktor pembelajaran dribbling dapatdiketahui bahwa sebanyak 85 % mempunyai motorik kasar baik , dan sebanyak 15 %mempunyai motorik kasar tidak baik. berdasarkan faktor pembelajaran shotting dapatdiketahui bahwa sebanyak 85 % mempunyai motorik kasar baik , dan sebanyak 15 %mempunyai motorik kasar tidak baik.Kata kunci: Kemampuan, Motorik Kasar, Bola Tangan
PERILAKU HIDUP SEHAT MEMBERS FITNESS CENTER GOR FIK UNY
Authors: Suryanto Eko Sucipto dan
Published: June 2020

Perilaku hidup sehat merupakan salah satu upaya untuk meningkatkan danmempertahankan kesehatan. Seiring dengan perkembangan jaman, banyak orangyang berperilaku hidup kurang sehat terutama berkenaan dengan gaya hidup ataulife style seperti minum minuman beralkohol, mengkonsumsi makanan yang tidaksehat, tidur tidak teratur, dan kurang berolahraga. Penelitian ini betujuan untukmengetahui perilaku hidup sehat members Fitness Center Gedung OlahragaFakultas Ilmu Keolahragaan Universitas Negeri Yogyakarta (GOR FIK UNY).Penelitian ini merupakan penelitian deskriptif. Populasi penelitian adalahmembers Fitness Center GOR FIK UNY. Sampel penelitian ini adalah membersFitness Center yang masih aktif sebanyak 50 orang. Teknik pengambilan sampelmenggunakan accidental sampling atau teknik sampling kebetulan, maksudnyaadalah apabila pemilihan anggota sampelnya dilakukan terhadap orang yangberbeda atau benda yang kebetulan ada atau dijumpai. Pengumpulan datamenggunakan angket. Hasil uji validitas diketahui dari 32 butir angket terdapat 4butir yang gugur yaitu nomor 6, 17, 22 dan 30 yang selanjutnya tidak digunakandalam pengambilan data penelitian. Hasil uji reliabilitas diperoleh koefisienreliabilitas sebesar 0,925 dan dinyatakan reliabel. Analisis data menggunakananalisis deskriptif dengan presentase.Hasil penelitian diketahui perilaku hidup sehat members fitness center GORFIK UNY dalam kategori cukup baik sebanyak 72 %. Perilaku terhadap makanandan minuman sebagian besar responden dalam kategori baik dan cukup baik.Perilaku terhadap kebersihan diri sebagian besar responden dalam kategori Baik.Perilaku terhadap kebersihan lingkungan sebagian besar responden dalam kategoricukup baik. Perilaku terhadap sakit dan penyakit sebagian besar responden dalamkategori cukup baik. Perilaku hidup yang teratur sebagian besar responden dalamkategori cukup baik.Kata kunci: perilaku hidup sehat, members fitness
TINGKAT PENGETAHUAN ATLET TENTANG CEDERA ANKLE DAN TERAPI LATIHAN DI PERSATUAN SEPAKBOLA TELAGA UTAMA
Authors: Rahmah Laksmi Ambardini Bimantoro Setio Nugroho ,
Published: June 2020

AbstrakPenelitian ini bertujuan untuk mengetahui seberapa jauh tingkat pengetahuan atlet tentang cedera ankle dan terapi latihan di Persatuan Sepakbola Telaga Utama. Penelitian ini merupakan penelitian deskriptif kuantitatif menggunakan metode survey dengan teknik pengambilan data menggunakan kuesioner. Populasi dalam penelitian ini adalah seluruh atlet sepakbola di PS Telaga Utama, pengambilan sampel penelitian ini adalah seluruh atlet sepakbola PS Telaga Utama yang berjumlah 30 orang. Teknik analisis data menggunakan deskriptif kuantitatif yang dinyatakan dalam persentase.Hasil penelitian ini menunjukkan bahwa tingkat pengetahuan atlet tentang cedera ankle dan terapi latihan di PS Telaga Utama sebagian besar (53,3 %) masuk dalam kategori kurang, sisanya (46,7 %) masuk dalam kategori sedang, dan tidak satupun masuk dalam kategori baik. Terdapat mitos-mitos keliru mengenai cedera ankle dan terapi latihan, sehingga membutuhkan pembenahan agar tingkat pengetahuan atlet bisa meningkat menjadi lebih baik.Kata kunci: Tingkat pengetahuan, terapi latihan cedera ankle, dan atlet.
TINGKAT KAPASITAS VITAL PARU ANAK TUNA RUNGU
Authors: Mustopa Rehania Nur'Aini , Sumaryanti Sumaryanti
Published: June 2020

Pernapasan sangat penting bagi kehidupan manusia dan ditunjang oleh beberapa faktor, salah satu di antaranya adalah kapasitas vital paru yang baik. Penelitian ini bertujuan untuk mengukur tingkat kapasitas vital paru anak tunarungu di SLB Karnnamanohara Kabupaten Sleman yang belum pernah diketahui sebelumnya. Penelitian ini merupakan penelitian deskriptif dengan menggunakan satu variabel, yaitu kapasitas vital paru. Sampel yang digunakan dalam penelitian ini adalah sampel populasi, yaitu siswa tunarungu yang berjumlah 142 anak di SLB Karnnamanohara Kabupaten Sleman yang terdiri atas siswa TKLB 25 anak, SDLB 98 anak, SMPLB 15 anak, dan SMALB 4 anak. Instrumen yang digunakan untuk mengumpulkan data berupa alat yaitu spirometer vitalograph. Untuk menganalisis data yang terkumpul, peneliti menggunakan teknik deskriptif kuantitatif. Hasil penelitian menunjukkan bahwa bahwa tingkat kapasitas vital paru anak tunarungu di SLB Karnnamanohara berada pada kategori kurang.
EFEKTIVITAS MANIPULASI “TOPURAK” UNTUK PENYEMBUHAN CEDERA SENDI LUTUT PASIEN LAB /KLINIK OLAHRAGA TERAPI DAN REHABILITASI FIK UNY
Authors: Rohim Muhammad Fathur , Kushartanti Wara
Published: June 2020

Cedera lutut yang ditandai dengan rasa nyeri merupakan cedera yang cukup sering. WHO 2008 menyatakan bahwa penderita nyeri sendi sebanyak 151 juta jiwa di dunia, hal ini merupakan sebuah kondisi yang sangat umum dialami oleh banyak orang, terutama bagi mereka yang banyak melakukan aktivitas fisik yang bertumpu pada lutut dan kaki. Penelitian ini bertujuan untuk mengetahui tingkat keefektifan manipulasi “Topurak” (totok, pukul, gerak) untuk penyembuhan cedera sendi lutut.Metode pre-experimental design dengan rancangan One Group Pretest-Posttest Design digunakan dengan populasi pasien cedera sendi lutut di Lab/ Klinik Olahraga Terapi dan Rehabilitasi – FIK UNY, pada bulan Januari – April 2017 secara insidental. Dari 75 pasien yang ditangani selama penelitian diambil sebanyak 20 orang yang bersedia sebagai sampel. Setelah dilakukan pretest untuk menilai tanda radang dan fungsional lutut, diterapi dengan manipulasi Topurak sebanyak tiga kali dengan selang-seling hari, dan masing-masing terapi berdurasi 5 menit. Setelah perlakuan terapi ke-tiga dilakukan post test. Semua data dideskripsikan, dan dilanjutkan dengan uji beda antara pretest dan post test untuk mengetahui seberapa efektivitas manipulasi Topurak. Hasil uji normalitas menunjukkan adanya distribusi normal pada data lingkar lutut atas, lingkar lutut tengah, skala nyeri, skala duduk berdiri, dan skala naik tangga, serta distribusi tidak normal pada lingkar lutut bawah, fleksi, ekstensi, dan skala kemampuan jalan. Uji beda dua kelompok berpasangan menggunakan sign test (non-parametrik).Hasil uji beda menunjukkan bahwa manipulasi Topurak efektif (p < 0,05) dalam menyembuhkan cedera sendi lutut yang ditunjukkan dengan menurunnya tanda radang, meningkatnya skala fungsi jalan, naik tangga dan duduk berdiri kecuali pembengkakan di lutut.
METODE PENGATURAN BERAT BADAN
Authors: Widiyanto -
Published: June 2020

Oleh:AbstrakTimbunan lemak dalam tubuh terjadi karena energi dariasupan gizi yang dikonsumsi setiap hari tidak seimbang dengankalori yang dikeluarkan untuk aktivitas fisik. Kelebihan kaloritersebut disimpan sebagai cadangan energi yang berupa lemak,yang akan disimpan sebagai jaringan adipose atau lemak subkutandisimpan di bawah kulit sehingga badan tampak gemukdan obesitas. Kegemukan atau obesitas, selain mengurangi rasapercaya diri berkaitan dengan penampilan fisik, diketahui meningkatkanrisiko berbagai penyakit degeneratif, sepertihipertensi, diabetes melitus, dan penyakit kardiovaskular.Menurunkan berat badan secara berlebihan itu sangatlahtidak baik. Berkurangnya berat badan berefek pada penurunantekanan darah, kolesterol, trigliserida dan resistensi msulm atauketidakseimbangan untuk menggunakan gula darah. Ingatbahwa kebugaran dihitung per unit berat badan, jadi jika lemakmeningkat, kebugaran akan menurun. Gabungan antara latihanfisik (olahraga) dan diet seimbang disertai dengan kemauanyang kuat sebagai alternatif untuk menjawab masalahpengaturan berat badan.Kata k u n c i : lemak tubuh, kegemukan, obesitas, olahraga, diet.
Полосковый сверхширокополосный полосно-пропускающий фильтр с уровнем подавления помех более 100 dB
Authors: Беляев Б.А. , Сержантов А.М. , Лексиков Ан.А. , Бальва Я.Ф. , Грушевский Е.О.
Published: June 2020

An ultra-wideband bandpass filter formed by a cascade connection of a new high-pass filter (HPF) and a low-pass filter (LPF), which are made on suspended substrates with a double-sided pattern of strip conductors, is under investigation. The high selectivity of the HPF is observed due to the presence of zero poles at the frequency response near the passband, which number is equal to the order of the filter. A second-order HPF, designed on a 0.5 mm thick substrate with a relative permittivity ε = 9.8, was synthesized using numerical electrodynamic analysis of its 3D model. The experimental HPF has the 3 dB cut-off frequency at fb = 0.25 GHz and it's passband extends up to 5 GHz. An ultra-wideband bandpass filter made by cascade connection of the low-pass filter and developed high-pass filter has a relative bandwidth Delta f / f0 = 150% with a central frequency f0 = 1 GHz. It has a wide and deep high-frequency stopband, which extends up to a frequency of 7.8f0 for the suppression level -100 dB.
Conversations and Misconceptions About Chemotherapy in Arabic Tweets: Content Analysis
Authors: Alghamdi Abdulrahman , Abumelha Khalid , Allarakia Jawad , Al-Shehri Ahmed
Published: June 2020

Background

Although chemotherapy was first introduced for the treatment of cancer more than 60 years ago, the public understanding and acceptance of chemotherapy is still debatable. To the best of our knowledge, no study has assessed the conversations and misconceptions about chemotherapy as a treatment for cancer on social media platforms among the Arabic-speaking populations.

Objective

The aim of this study was to assess the types of conversations and misconceptions that were shared on Twitter regarding chemotherapy as a treatment for cancer among the Arabic-speaking populations.

Methods

All Arabic tweets containing any of the representative set of keywords related to chemotherapy and written between May 1, 2017 and October 31, 2017 were retrieved. A manual content analysis was performed to identify the categories of the users, general themes of the tweets, and the common misconceptions about chemotherapy. A chi-square test for independence with adjusted residuals was used to assess the significant associations between the categories of the users and the themes of the tweets.

Results

A total of 402,157 tweets were retrieved, of which, we excluded 309,602 retweets and 62,651 irrelevant tweets. Therefore, 29,904 tweets were included in the final analysis. The majority of the tweets were posted by general users (25,774/29,904, 86.2%), followed by the relatives and friends of patients with cancer (1913/29,904, 6.4%). The tweets were classified into 9 themes; prayers and wishes for the well-being of patients undergoing chemotherapy was the most common theme (20,288/29,904, 67.8%), followed by misconceptions about chemotherapy (2084/29,904, 7.0%). There was a highly significant association between the category of the users and the themes of the tweets (χ240= 16904.4, P<.001).

Conclusions

Our findings support those of the previous infodemiology studies that Twitter is a valuable social media platform for assessing public conversations, discussions, and misconceptions about various health-related topics. The most prevalent theme of the tweets in our sample population was supportive messages for the patients undergoing chemotherapy, thereby suggesting that Twitter could play a role as a support mechanism for such patients. The second most prevalent theme of the tweets in our study was the various misconceptions about chemotherapy. The findings of our exploratory analysis can help physicians and health care organizations tailor educational efforts in the future to address different misconceptions about chemotherapy, thereby leading to increased public acceptance of chemotherapy as a suitable mode of treatment for cancer.
MyStrengths, a Strengths-Focused Mobile Health Tool: Participatory Design and Development
Authors: Jessen Stian , Mirkovic Jelena , Nes Lise Solberg
Published: June 2020

Background

People living with chronic illnesses are an increasingly large group. Research indicates that care and self-management should not only focus on the illness and problem-oriented aspects of these individuals’ lives but also support them in recognizing and leveraging their personal strengths in daily life.

Objective

This paper presents the design and developmental process of MyStrengths, a mobile health (mHealth) app designed to help its users (people with chronic conditions) both find and make use of their personal strengths in their daily lives. Through 4 consecutive phases, this paper presents participant- and researcher-driven activities, discussions regarding design, and development of both the MyStrengths app and its content.

Methods

During the 4 phases, we used a range of methods and activities, including (1) an idea-generating workshop aimed at creating ideas for strengths-supporting features with different stakeholders, including patients, caregivers, relatives, and designers (N=35); (2) research seminars with an international group of experts (N=6), in which the concept, theoretical background, and design ideas for the app were discussed; (3) a series of co-design workshops with people in the user group (N=22) aiming to create ideas for how to, in an engaging manner, design the app; and (4) in 4 developmental iterations, the app was evaluated by people in the user group (N=13). Content and strengths exercises were worked on and honed by the research team, the expert groups, and our internal editorial team during the entire developmental process.

Results

The first phase found a wide range of stakeholder requirements to, and ideas for, strengths-focused mHealth apps. From reviewing literature during the second phase, we found a dearth of research on personal strengths with respect to people living with chronic illnesses. Activities during the third phase creatively provided numerous ideas and suggestions for engaging and gameful ways to develop and design the MyStrengths app. The final phase saw the output from all the earlier phases come together. Through multiple increasingly complete iterations of user evaluations testing and developing, the final prototype of the MyStrengths app was created.

Conclusions

Although research supports the use of strengths-focused mHealth tools to support people living with chronic illnesses, there is little guidance as to how these tools and their content should be designed. Through all activities, we found great support among participating users for strengths-focused apps, and we can consider such apps to be both appropriate and valuable. This paper illustrates how combining a range of user-, researcher-, literature-, and designer-based methods can contribute to creating mHealth tools to support people with chronic illnesses to find and use more of their own personal strengths.
Prospective Associations Between Working Time Arrangements and Psychiatric Treatment in Denmark: Protocol for a Cohort Study (Preprint)
Authors: Hannerz Harald , Albertsen Karen , Nielsen Martin Lindhardt , Garde Anne Helene
Published: June 2020

BACKGROUND

The burden of mental ill health in working-age populations has prompted research on possible links between work-related factors and mental ill health. Long working hours and night shift work are some of the factors that have been studied in relation to the risk of developing mental ill health. Yet, previous studies have not generated conclusive evidence, and further studies of high quality are needed.

OBJECTIVE

This study aims to investigate the prospective association between working time arrangements and mental health in terms of psychotropic drug usage or psychiatric hospital treatment in the general working population of Denmark.

METHODS

Data on total weekly working hours in any job and night shift work from the Danish Labor Force Survey 2000–2013 will be linked to data from the Psychiatric Central Research Register (expected 2400 cases during 700,000 person years at risk) and National Prescription Registry (expected 17,400 cases during 600,000 person years at risk). Participants will be followed for up to 5 years. We will use Poisson regression to separately analyze incidence rates of redeemed prescriptions for psychotropic medicine and incidence rates of psychiatric hospital treatment due to mood disorders, anxiety disorders, or stress-related disorders as a function of weekly working hours and night shift work. The analyses will be controlled for sex, age, calendar time of the interview, and socioeconomic status.

RESULTS

This is a study protocol. Power calculations indicate that the study has sufficient statistical power to detect relatively small differences in risks and minor interactions (eg, ~90% power to detect a rate ratio of 1.1 for psychoactive medication use). We expect the analyses to be completed by the end of 2020 and the results to be published in 2021.

CONCLUSIONS

In this study protocol, all hypotheses and statistical models of the project have been completely defined before we link the exposure data to the outcome data. The results of the project will indicate to what extent and in what direction the national burden of mental ill health in Denmark has been influenced by long working hours and night shift work.

INTERNATIONAL REGISTERED REPORT

DERR1-10.2196/18236
Improving the Management of Atrial Fibrillation in General Practice: Protocol for a Mixed Methods Study (Preprint)
Authors: de Lusignan Simon , Hobbs F D Richard , Liyanage Harshana , Ferreira Filipa , Tripathy Manasa , Munro Neil , Feher Michael , Joy Mark
Published: June 2020

BACKGROUND

Atrial fibrillation (AF) is one of the commonest arrhythmias observed in general practice. The thromboembolic complications of AF include transient ischemic attack, stroke, and pulmonary embolism. Early recognition of AF can lead to early intervention with managing the risks of these complications.

OBJECTIVE

The primary aim of this study is to investigate if patients are managed in general practice according to current national guidelines. In addition, the study will evaluate the impact of direct oral anticoagulant use with respect to AF complications in a real-world dataset. The secondary aims of the study are to develop a dashboard that will allow monitoring the management of AF in general practice and evaluate the usability of the dashboard.

METHODS

The study was conducted in 2 phases. The initial phase was a quantitative analysis of routinely collected primary care data from the Oxford Royal College of General Practitioners Research and Surveillance Center (RCGP RSC) sentinel network database. AF cases from 2009 to 2019 were identified. The study investigated the impact of the use of anticoagulants on complications of AF over this time period. We used this dataset to examine how AF was managed in primary care during the last decade. The second phase involved development of an online dashboard for monitoring management of AF in general practice. We conducted a usability evaluation for the dashboard to identify usability issues and performed enhancements to improve usability.

RESULTS

We received funding for both phases in January 2019 and received approval from the RCGP RSC research committee in March 2019. We completed data extraction for phase 1 in May 2019 and completed analysis in December 2019. We completed building the AF dashboard in May 2019. We started recruiting participants for phase 1 in May 2019 and concluded data collection in July 2019. We completed data analysis for phase 2 in October 2019. The results are expected to be published in the second half of 2020. As of October 2020, the publications reporting the results are under review.

CONCLUSIONS

Results of this study will provide an insight into the current trends in management of AF using real-world data from the Oxford RCGP RSC database. We anticipate that the outcomes of this study will be used to guide the development and implementation of an audit-based intervention tool to assist practitioners in identifying and managing AF in primary care.

INTERNATIONAL REGISTERED REPORT

RR1-10.2196/21259
Web searches related to insomnia correlate with the escalation/de-escalation measures enforced during the COVID-19-induced quarantine and lockdown in Italy: insights from a Big Data-based infodemiological survey (Preprint)
Authors: Bragazzi Nicola Luigi , Garbarino Sergio
Published: June 2020

BACKGROUND

Since late December, a novel, emerging coronavirus has quickly spread out from the first epicenter, the city of Wuhan, province of Hubei, mainland China, becoming a pandemic. To contain the outbreak unprecedented public health measures have been enforced, including self-isolation, physical/social distancing, quarantine and lockdown of entire communities and territories. Despite being effective, these interventions are imposing a severe psycho-social distress.

OBJECTIVE

In the present investigation, we assessed the impact of behavioral non pharmacological interventions in terms of digital activities related to sleep disorders and specifically insomnia in Italy, one of the countries hit hard by the pandemic.

METHODS

We used a Big Data-based infodemiological approach, employing Google Trends, an open source instrument enabling real-time tracking and monitoring of web searches and digital activities.

RESULTS

We found that, on average, during the three months of quarantine and lockdown, searches related to COVID-19 and insomnia represented 6.8% and 12.4% of the entire search volumes related to COVID-19 and insomnia, respectively, peaking on May 17th 2020. A significant different in the geographic location of searches could be noted. The COVID-19 quarantine has caused an increase in searches related to insomnia. More in detail, the volumes correlated with the escalation of the measures adopted, decreasing during the de-escalation/re-opening phases.

CONCLUSIONS

Healthcare providers and other relevant stakeholders, when enforcing particularly restrictive measures, should routinely employ Big Data-based tools in order screen for sleep problems such as insomnia and other mental issues, in that sleep is a vital and integral component of human life and normal emotional functioning, and sleep disturbances can lead to or worsen pre-existing mental health diseases.
SYNTHESIS, THERMAL REACTIVITY, AND ANTIOXIDANT STUDIES OF AMINOGUANIDINIUM SALTS OF ASPARTIC AND GLUTAMIC ACIDS
Authors: S PARVEEN , D MANIKANDAN , S GOVINDARAJAN , PA PERIASAMY
Published: June 2020

Objective: Our main scope and objectives are to prepare aminoguanidinium salts of amino acids and to characterize them using analytical, IR, and thermal studies, to study the mode of thermal decomposition of aminoguanidinium salts, and to characterize the antioxidants behavior of aminoguanidinium salts.

Methods: Elemental analysis for C, H, and N was performed on a Vario ELIII elemental analyzer. The IR spectra were recorded on a JASCO-4100 spectrophotometer as KBr pellets in the range of 400–4000 cm-1. The simultaneous TG-DTA studies were under taken on a PerkinElmer SII thermal analyzer and the curves obtained in air using platinum cups as holders with ~ 3 mg of the samples at the heating rate of 10°C/min. The antioxidant capacities of different salts were estimated according to the literature procedure.

Results: Aspartic acid forms bis-aminoguanidinium salt, whereas glutamic acid forms both mono- and bis-aminogunidinium salts. The IR spectral data of the aminogunidinium salts of aforesaid acids show N-N stretching frequencies in the region 1110–1202 cm-1 revealing the presence of aminoguanidinium moiety.

Conclusion: The antioxidant properties of these salts were studied using ferric reducing antioxidant power and phosphomolybdenum assay. Results showed significant ferric reducing power which indicated the hydrogen-donating ability of the extract.
BACTERICIDAL ACTIVITY OF WILD AND HYBRID VARIETIES OF SYZIGIUM CUMINI L. AGAINST A FEW PLANT PATHOGENS
Authors: D HERIN SHEEBA GRACELIN
Published: June 2020

Objective: The objective of the present study was to analyze the antibacterial activity of seeds of wild and hybrid varieties of Syzygium cumini against plant pathogens such as Erwinia herbicola, Pseudomonas syringae, and Xanthomonas campestris.

Methods: The phytochemicals from the wild and hybrid varieties of S. cumini seeds collected from the Tirunelveli region (Tamil Nadu) were extracted by cold methanol method. Antibacterial activity of the methanol extract of seeds has been tested against E. herbicola, P. syringae, and X. campestris by disc diffusion assay.

Results: The seed extract of wild variety revealed more effective antimicrobial activity than a hybrid variety with minimum inhibitory concentration ranging from 8 μg/ml to 128 μg/ml. The highest inhibition zone was exhibited by wild seed extract against X. campestris (16.3 mm).

Conclusions: This result showed that the wild variety of S. cumini seeds may be the best antibacterial agent against plant pathogens.
PROTECTIVE EFFECT OF AQUEOUS EXTRACT OF LEAVES OF MURRAYA KOENIGII, AGAINST ALUMINUM CHLORIDE-INDUCED OXIDATIVE STRESS IN RAT LIVER AND KIDNEY
Authors: REDDY B MAHESWARI , CK DHANAPAL , BVS LAKSHMI
Published: June 2020

Objective: The aim of the current study was to investigate the hepatoprotective, nephroprotective, and cholesterol-lowering activity of aqueous extract of Murraya koenigii (MK) leaves against AlCl3-induced oxidative stress in rats.

Methods: Wistar albino rats were distributed into six groups (6 each). Group I (control), and Group II administered with distilled water, and aluminum chloride (AlCl3), (40 mg/kg body weight [b.w], oral), respectively. Group III rats were treated with standard Vitamin E (100 mg/kg b.w, p.o) and AlCl3 (40 mg/kg b.w, oral). Group IV, V, and VI received aqueous extract of leaves of Murraya koenigii (AEMK) (100 mg/kg b.w, peroral [p.o], 200 mg/kg b.w, p.o, and 400 mg/kg b.w, p.o), respectively, for a period of 35 days.

Results: Histopathological examination was observed deformities in hepatic and renal tissues due to aluminum exposure which augment the aforementioned results. Coadministration of AEMK along with Al significantly restored the serum biomarkers to their near-normal levels and has the ability to overcome Al-induced oxidative stress, manifested by a significant reduction in hepatic and renal malondialdehyde level. It increased cellular antioxidant defense, particularly by increasing GPx, glutathione, GR, and catalase levels, preserved normal hepatic and renal histological architecture.

Conclusion: It could be concluded that AEMK has significant radical scavenging activity and can mop up Al-induced toxicity, suggesting hepatoprotective and nephroprotective potential.
José Batlle y Ordóñez y la economía política de su tiempo
Authors: Aguerre María Luisa
Published: June 2020

En este trabajo se pretende demostrar que los fundamentos del paradigma reformista de la democracia liberal, al cual denominamos hoy Estado de Bienestar, se fue conformando durante la segunda mitad del siglo XIX, en oposición al socialismo, que también pugnaba por la transformación de la sociedad y su economía mediante la estatización de los medios de producción. En segundo lugar analizaremos las principales teorías de los grandes economistas de ese tiempo, a las cuales adjudicamos una gran influencia en la aceptación del intervencionismo estatal para reformar la vida de las sociedades, manteniendo al mismo tiempo el régimen de libre competencia de los mercados. Y cómo José Batlle y Ordóñez, a quien consideramos conocedor de las teorías del nuevo paradigma, las aplicó en el Uruguaydurante sus dos presidencias, cambiando las estructuras económicas del país, asegurando al mismo tiempo las libertades democráticas y el capitalismo dentro de un mercado regulado por el Estado.
Seré famoso algún día algún día
Authors: Fortoul van der Goes Teresa I.
Published: June 2020

For some reason, creators are more likely to die at the age of 27. Several singers and songwriters often fell by the wayside, as consequence of an overdose. Names like Jimmy Hendrix, Amy Weinhouse, Janis Joplin, Jim Morrison and to this list we add Jean-Michel Basquait. What do they have in common? A success that they did not know how to handle? "The Radiant Child" could not escape that curse ...drugs, success and 27 years
Physical activity and eating habits of students of the University of Belgrade: An epidemiological study
Authors: Obradovic Milos , Nesic Goran , Popovic Aleksandra , Bozic Predrag , Savic Zoran , Kojic Filip , Djuric Sasa
Published: June 2020

Background/Aim. Numerous studies have indicated that university students exhibit a variety of risky health behaviors, such as the lack of regular physical activity and u n-healthy eating habits. Due to lack of information about students? lifestyles in Serbia, we designed a study with the following aims: 1) to investigate physical activity and eating habits variations of students according to gender, year of study and attended faculty; 2) to estimate the relationship between their physical activity and eating habits. Methods. The survey method was used. Data were collected in the 2016/2017 school year during the spring semester. The sample was randomly stratified (4,019 students of the University of Belgrade ? 2,284 males), which corresponded to about 5% of the whole student population of the University of Belgrade. For data collection, two standardized questionnaires were used: International Physical Activity Questionnaire (IPAQ) and Youth/Adolescent Food Questionnaire (YAQ). Results. Male students were significantly more highly and moderately active than female students [3.15 vs. 2.80 days, respectively; p = 0.003, effect size (ES) = 0.651]. Correspondingly, female students were less active during the day (326 vs. 305 min; p = 0.044, ES = 0.232). Interaction between factors revealed that the most active on a weakly basis were fourth-year male students of the natural sciences (4.20 days), while on a daily basis, the most active were first-year female students (161 min). The most sedentary ones were third-year female students of medical sciences (475 min of sitting per day). Significant correlations were found between the duration of intense physical activity and consuming water, vegetables, citrus fruits, integral bread, and cereals. Conclusion. Female students were more prone to sedentary behavior, while older students were more active and aware of the importance of physical activity. Further-more, the nature of studies can influence the lifestyle. Female and older students were more concerned about diets. Additionally, students who were more physically active had healthier eating habits.
1001-P: Do-It-Yourself (DIY) Loop Is Associated with Psychosocial Benefits
Authors: HOOD KOREY K. , WONG JESSIE J. , HANES SARAH , BAILEY RYAN , CALHOUN PETER , BECK ROY , BARNES-LOMEN VICTORIA R. , LUM JOHN W. , ARBITER BRANDON , NARANJO DIANA
Published: June 2020

Loop is a DIY app for automated insulin delivery using an iPhone and commercial continuous glucose monitor (CGM) and insulin pump. An ongoing observational study evaluates glycemic control, adverse event rates, and patient-reported outcomes (PROs) among adults with type 1 diabetes (T1D). This abstract presents PROs data for the first 3 months using Loop.

Participants were recruited through online postings and packaging of the Loop RileyLink. Device data were collected via the Tidepool Mobile App, including available CGM data at enrollment. PROs evaluated diabetes distress, technology attitudes and problem solving, hypoglycemia fears and confidence, and sleep quality with validated surveys.

There were 290 new users who started Loop within the past 7 days. Complete data were available for 254; 5 stopped using Loop and 31 did not complete PROs at 3 months. Demographic and clinical characteristics are in the Table. t tests and effect sizes showed statistically (p<0.05) and clinically significant (d=0.2-0.6) benefits of less distress and hypoglycemia fear, more confidence in catching hypoglycemia, and better sleep quality. Users were consistent in their report of average ease to start Loop and Loop performing very well day and night. Over 90% would recommend Loop (scores of 4 or 5).

This is the first study to systematically measure PROs in people using a DIY system, with new users voicing high satisfaction and across the board positive PRO scores.

Disclosure

K.K. Hood: Research Support; Self; Dexcom, Inc. Speaker’s Bureau; Self; LifeScan, Inc., MedIQ. J.J. Wong: None. S. Hanes: None. R. Bailey: None. P. Calhoun: Stock/Shareholder; Self; Dexcom, Inc. R. Beck: None. V.R. Barnes-Lomen: None. J.W. Lum: None. B. Arbiter: Employee; Self; Tidepool. Stock/Shareholder; Self; Abbott Laboratories, Dexcom, Inc., Tandem Diabetes Care. D. Naranjo: None.

Funding

The Leona M. and Harry B. Helmsley Charitable Trust
1048-P: Fasting C-Peptide as a Predictor for Hypoglycemia Risk and HbA1c Reduction in Chinese T2DM Patients Switching from Premixed to Basal Insulin: A Post Hoc Analysis from the Optimization Study
Authors: YANG WENYING , RUAN PENGFEI , ZHANG XIA , CUI NAN
Published: June 2020

Objective: To explore the predictive effect of baseline fasting C-peptide (FCP) on hypoglycemia risk, HbA1c reduction, and treatment satisfaction in Chinese T2DM individuals switching from premixed to basal insulin.

Methods: Post-hoc analysis of the single-arm, 16 weeks, phase IV OPTIMIZATION study. At 16 weeks, the study showed a mean reduction in HbA1c of 0.51% with basal insulin treatment after switching from premix. Study completers with baseline FCP testing (n=297) were stratified according to HbA1c <7.5% achievement or actual decrease at 16 weeks. In addition, hypoglycemia and patient feelings during treatment using DTSQ score were assessed. Different FCP thresholds were analyzed with Chi-square test and multivariate logistic regression analysis to test whether baseline FCP could be used to predict clinical results.

Results: When looking at efficacy alone, FCP >1.0 nmol/L could be used for predicting a higher probability to reach HbA1c <7.5% (OR=3.83, 95%CI 1.89, 7.73) and higher probability to achieve a HbA1c decrease >0.4% (OR=3.19, 95%CI 1.54, 6.59). By dividing participants using FCP dichotomy, similar results were obtained in people with FCP >0.59 nmol/L. When combined with overall hypoglycemia, both thresholds of FCP >1.0 nmol/L (OR=2.78, 95%CI 1.36, 5.68) and >0.59 nmol/L (OR=1.83, 95%CI 1.01, 3.30) predicted HbA1c <7.5% achievement without hypoglycemia. Similar results were also obtained for predicting both HbA1c<7.5% and better DTSQ score results.

Conclusion: Baseline fasting C-peptide could be used as a biomarker to predict greater HbA1c reduction, less hypoglycemia and better satisfaction in Chinese T2DM people switching from premixed to basal insulin.

Disclosure

W. Yang: Speaker’s Bureau; Self; AstraZeneca, Bayer Inc., Boehringer Ingelheim Pharmaceuticals, Inc., Eli Lilly and Company, Merck and Servier, Merck Sharp & Dohme Corp., Novo Nordisk Inc., Sanofi-Aventis. P. Ruan: Employee; Self; Sanofi. X. Zhang: None. N. Cui: None.
1063-P: Effects of Bromocriptine Quick-Release (BCQR) Therapy on Glycemic Control, Insulin Sensitivity, and Vascular Function in Type 1 Diabetes (T1D)
Authors: TELL SHOSHANA , SNELL-BERGEON JANET K. , VIGERS TIMOTHY B. , BAUMGARTNER AMY , LYON ELLEN , GROSS SUSAN , SCHÄFER MICHAL , POLSKY SARIT , NADEAU KRISTEN J. , SCHAUER IRENE E.
Published: June 2020

BCQR is approved for adjunct therapy in type 2 diabetes (T2D). BCQR improves glycemic control and appears to reduce cardiovascular events in T2D. People with T1D have decreased insulin sensitivity (IS), correlating with vascular dysfunction. We evaluated the effects of BCQR on glycemic control, estimated IS, and vascular function in a random order, placebo-controlled crossover study of a 4-week intervention with BCQR in adolescents (12-21 yrs) and adults (22-60 yrs) with T1D. Outcomes included: insulin total daily dose (TDD), urine albumin to creatinine ratio (UACR), vascular markers using Dynapulse and EndoPAT, CGM, estimated IS scores (from CACTI and RESISTANT study models), and a mixed meal tolerance test (MMTT). Treatment effect was examined in mixed models and reported as LS mean ± SE adjusted for age, sex, phase, and treatment order. Interactions were examined by age and diabetes duration (DD).

Participants‡ (n=84) were 50% adult, age 28.6 ± 14.5 yrs, 44% male, and 49% lean, with HbA1c 7.8% [7, 8.5] and DD 14.2 ± 11.7 yrs. Insulin TDD, log UACR, and CGM outcomes (average glucose, SD, % time BG>180 or <70 mg/dL) did not differ by treatment. SBP was lower on BCQR (114 ± 1.2 vs. 118 ± 1.2, p=0.0001). DBP was lower on BCQR in those with DD>5 yrs (68 ± 1.2 vs. 72 ± 1.2, p=0.0038). Reactive hyperemia index (endothelial function estimate) was lower on BCQR in adolescents (2.03 ± 0.12 vs. 2.32 ± 0.12, p=0.0039), and systemic vascular resistance (SVR) was lower on BCQR in adults (1408 ± 62 vs. 1479 ± 63, p=0.006). Dynapulse cardiac output and brachial artery distensibility did not differ by treatment. MMTT triglyceride (TG) peak minus baseline was lower on BCQR (22 ± 3.0 vs. 27 ± 2.9, p=0.0360). IS measured by MMTT fasting and AUC glucose/insulin, and by CACTI and RESISTANT scores, did not differ by treatment. In sum, BCQR did not affect CGM glycemia or estimated IS, but it improved cardiovascular measures such as SBP, DBP, SVR, and TG.

‡Mean ± SD or Median [Interquartile Range].

Disclosure

S. Tell: None. J.K. Snell-Bergeon: Stock/Shareholder; Self; GlaxoSmithKline plc. T.B. Vigers: None. A. Baumgartner: None. E. Lyon: None. S. Gross: None. M. Schäfer: None. S. Polsky: None. K.J. Nadeau: None. I.E. Schauer: None.

Funding

JDRF (3-SRA-2015-125-M-R)
1069-P: Effect of Sacubitril/Valsartan Combination Therapy in Type 2 Diabetes Mellitus Patients with Elevated NT-proBNB and Preserved Ejection Fraction
Authors: GUPTA VISHAL , TELI VAISHALI
Published: June 2020

Aim: study the effect of Sacubitril/valsartan (SV) combination therapy on cardio-renal (CR) biomarkers in T2DM with preserved ejection fraction (pEF); diastolic dysfunction and or LVH on 2D echocardiogram (E) and elevated N-terminal prohormone B-type natriuretic peptide (NT-proBNP) >125.

Methodology: between July and Sept 2018, 109 T2DM patients aged 18-75 yrs, irrespective of baseline A1c, receiving SV were identified. Patients were analysed every 2-3months for CR biomarkers (body mass index (BMI), A1c, systolic (S) BP, diastolic (D) BP, Lipid profile (TC, LDL, TG, HDL), Hs-CRP, NT-ProBNP, creatinine, eGFR and microalbumin/creatinine ratio {UACR} and data presented at 1 yr. T2DM with H/O IHD, reduced EF(<50%) or wall motion abnormalities on E, malignancy, major surgery, hyperkalemia >5.5Meq/L and eGFR<45 were excluded. Baseline characteristics were analyzed using descriptive statistics. Continuous variables were analysed using paired and unpaired t-test expressed as mean ± standard error. For interaction between drug class, ANOVA was used and p value <0.05 was considered significant (S).

Results: Baseline characteristics: Male 43%, Female 66%. Avg (age 63.16 ±8.325yrs, BMI 30.45±5.52, A1c% 7.1±1.2, egfr 90.31±30.45, UACR mg/gm 180.07±553.4, hs-CRP mg/dl 2.53±3.41, NT-proBNP 370.07±543.30 Ng/L). 64.2% received canagliflozin, 11.9% liraglutide, 94.5% Metformin, 61.5% gliptins, 65.1% gliclazide, 44% calcium channel blockers and 100% statin (rosuvastatin) Baseline (B) to 1yr: There was S reduction in SBP, DBP, A1c, TC, LDL, HDL, UACR, hs-CRP and NT-ProBNP NT-proBNP: there was S reduction from B to 3 mths (84.26±31.86, p-0.009), 6mth - 12 mths (39.95±17.40,p-0.024) and B-12mths (155.69±744.10,p-0.001). There was no diff seen 3-6mths (38.09±38.03, p-0.320). There was an interaction seen with Liraglutide in terms of NT-proBNP and UACR.

Conclusion: SV may be effective in reducing NT-ProBNP in T2DM with pEF

Disclosure

V. Gupta: None. V. Teli: None.
109-LB: Early Detection of Cutaneous Complications of Insulin Therapy in Type 1 and Type 2 Diabetes
Authors: ARORA SAURABH
Published: June 2020

Objective: Our objective was to assess the prevalence of cutaneous complications including insulin derived amyloidosis in insulin-injecting diabetes patients and to study the role of ultrasonography (in comparison to gel-assisted palpation) in early diagnosis of lipohypertrophy.

Methods: This was a cross-sectional study conducted at a tertiary care center in India. A total of 500 patients injecting insulin for two or more years were enrolled and subjected to ultrasonographic examination of abdominal wall to look for presence of lipohypertrophy (LH). All cases with radiological evidence of LH were given the option of punch biopsy of the skin and subcutaneous tissue to look for insulin associated amyloidosis.

Results: Clinical examination detected LH in 44.6% of patients. Ultrasonography diagnosed additional 13.4% of patients with LH which were missed on clinical examination. Incorrect rotation of sites (P < 0.001) and insulin syringe reusage for more than five times (P < 0.001) significantly increased the risk of LH . Skin biopsy was performed in 100 cases, of which two patients showed apple green birefringence and positive staining with anti-insulin antibody suggestive of insulin derived amyloidosis.

Conclusion: Ultrasonography is more objective and reliable method of detecting LH. Insulin-derived amyloidosis may be a more common complication of insulin therapy than previously thought.

Disclosure

S. Arora: None.
1090-P: MSDC-0602k, a New Oral Insulin Sensitizer in Insulin Resistant NASH Patients with and without Type 2 Diabetes (T2D)
Authors: COLCA JERRY R. , LEE BO HYUN , IWASHITA JULIE S. , DITTRICH HOWARD C. , HARRISON STEPHEN A.
Published: June 2020

Use of the first-generation insulin sensitizer pioglitazone is limited by PPARγ-driven side effects. MSDC-0602K was designed to maintain pioglitazone’s effects on the mitochondrial pyruvate carrier (MPC), but with minimal direct PPARγ binding. A 12-month Phase 2b dose-ranging study in NASH (Harrison et al, 2019) demonstrated insulin sensitizing pharmacology without dose-limiting issues. Here we describe ongoing analysis of these data. Steady state exposures of drug and active metabolite at the highest doses averaged 4 to 7 micromolar, 1/10thof the affinity to PPARγ, but within the range for modulation of the MPC in intact cells. The effects on fasting plasma insulin (FPI), fasting plasma glucose, and hemoglobin A1c (HbA1c) plateaued at the mid-dose (125 mg), while adiponectin continued to increase 1.7, 2.5, and 4.1x vs. placebo across the 62.5, 125, and 250 mg doses. Glycemic reductions and the reduction of FPI levels were similar in subjects with or without T2D. The treatment-induced decrease in HbA1c was proportional to the baseline HBA1c and was more than 1% in subjects with a baseline above 7%, including those not well-controlled on GLP-1 agonists. In patients with or without diabetes, baseline mean FPI levels exceeded 20 μU/ml (139 pmol/L), levels in the upper quartile of historical T2D studies, and continued to increase in placebo-treated subjects but decreased on treatment with MSDC-0602K. Treatment with MSDC-0602K decreased FPI more than C-peptide. The ratio of C-peptide/FPI increased vs. placebo at end of study (8.54 ± 0.49, 9.69 ± 0.44, 10.45 ± 0.43, and 10.9 ± 0.53 for placebo and the three dose groups, respectively) suggesting both decreased need for secreted insulin and increased clearance of insulin. These data suggest that the new generation insulin sensitizer MSDC-0602K, focused toward MPC and away from PPAR, may be useful to treat patients suffering from combined fatty liver disease and T2D and highlight the importance of FPI.

Disclosure

J.R. Colca: Stock/Shareholder; Self; Cirius Therapeutics, Metabolic Solutions Development Company. B. Lee: Employee; Self; Cirius Therapeutics. J.S. Iwashita: Employee; Self; Cirius Therapeutics. H.C. Dittrich: Employee; Self; Cirius Therapeutics. S.A. Harrison: Consultant; Self; Akero, Altimmune, Axcella, Cirius, Cirius Therapeutics, Genentech, Inc., Hightide Bio, HistoIndex, Intercept Pharmaceuticals, Inc., Madrigal.