COMPARATIVE ASSESSMENT OF MORBIDITY AMONG PATIENTS WITH DIFFERENT METHODS OF CONCEPTION IN THE DEPARTMENT OF PREGNANCY PATHOLOGY
Authors:   St. Petersburg State Pediatric Medical University of the Ministry of Health of the Russian Federation, St. Petersburg, Russia, Moiseeva Karina , Kharbediya Shalva ,   St. Petersburg State Pediatric Medical University of the Ministry of Health of the Russian Federation, St. Petersburg, Russia, Taits Anna ,   St. Petersburg State Pediatric Medical University of the Ministry of Health of the Russian Federation, St. Petersburg, Russia, Shevtsova Kseniya ,   St. Petersburg State Pediatric Medical University of the Ministry of Health of the Russian Federation, St. Petersburg, Russia, Bolotskikh Vyacheslav ,   St. Petersburg State University, St. Petersburg, Russia, Ivanova Lada ,   Maternity Hospital No.10, St. Petersburg, Russia, Kolotova Anna ,   St. Petersburg State Pediatric Medical University of the Ministry of Health of the Russian Federation, St. Petersburg, Russia
Published: October 2024

Significance. Despite the availability and effectiveness of assisted reproductive technologies, a significant share of the population still has a biased attitude towards in vitro fertilization. Considering a rising prevalence of in vitro fertilization, a comparative morbidity assessment of patients with different types of conception in the department of pregnancy pathology is a relevant research topic. The purpose of the study is to conduct a comparative assessment of morbidity among patients with different methods of conception in the department of pregnancy pathology with a breakdown on age. Material and methods. Using the copy-pair method, data were copied from 1640 forms No. 003/u on patients in the pregnancy pathology department of the perinatal center of St. Petersburg State Pediatric Medical University. Each patient who overcame infertility with the help of in vitro fertilization, was paired with a peer whose pregnancy occurred naturally based on age, marital status and place of residence. The significance of differences in indicators was assessed using Student's t-test. Differences were considered significant at p<0.05. Statistical data processing was carried out using the MS Office-2016 and StatSoft-Statistica 10.0 software packages. Results. In patients of the Department of Pregnancy Pathology who overcame infertility using in vitro fertilization, compared to their peers with natural conception, there was a higher prevalence of preeclampsia, complications caused by acute respiratory viral infections and Covid-19, isthmic-cervical insufficiency, pathology of the placenta, anemia, diseases of the endocrine system, disorders of the hemostasis system and uterine fibroids. At the same time, the frequency of oligohydramnios, polyhydramnios, varicose veins and diseases of the genitourinary system was lower. There were no significant differences in the incidence of gestational diabetes mellitus and myopia between the two groups. Assessment of the effect of age on the morbidity of patients whose pregnancy occurred with the help of in vitro fertilization showed that for most diseases there were no significant differences between women aged 35 and older and pregnant women under 35. It was found that older in vitro fertilization patients had significantly fewer complications caused by infectious diseases, and yet were more likely to experience preeclampsia, polyhydramnios, varicose veins, disorders of the hemostatic system and uterine fibroids. Conclusion. A comparative assessment of the frequency of pregnancy complications and extragenital pathology in patients with different methods of conception in the pregnancy pathology department showed reliable significant differences in the prevalence of individual diseases. The influence of age on morbidity that complicated pregnancy in patients of the pregnancy pathology department was established. Scope of application. The information obtained can be used by obstetricians-gynecologists and health administrators to improve care delivery to women who have overcome infertility with the use of assisted reproductive technologies.