bluuebunny/crossref_metadata_2025 huggingface dataset:
CHEYLETIELLA DERMATITIS
Authors: POWELL RALPH F. , PALMER SUSAN M. , PALMER CHARLES H. , SMITH EDGAR B.
Published: March 2008

ABSTRACT: A mild dermatitis probably due to Cheyletiella yasguri was observed in 2 persons whose pet dog was infested with this parasite. Cheyletiella mites differ morphologically from sarcoptic mites, which cause canine and human scabies. Treatment of man and dog with 1% gamma benzene hexachloride is usually successful in clearing this condition.
PAPULAR MUCINOSIS
Authors: COSKEY RALPH J. , MEHREGAN AMIR
Published: March 2008

ABSTRACT: Most patients previously reported to have papular mucinosis had the generalized lichenoid papular form (scleromyxedema) with abnormal gamma globulin. Microscopic examination of affected skin showed increased acid mucopolysaccharides in the dermis and proliferation of fibroblasts. Our patient had the discrete form of papular mucinosis without abnormal serum gamma globulin but with increased amounts of acid mucopolysaccharides in the dermis and no proliferation of fibroblasts.
PRIMARY AND RECURRENT HERPETIC WHITLOW
Authors: CHANG TE‐WEN , GORBACH SHERWOOD L.
Published: March 2008

ABSTRACT: Herpetic whitlow has been reported as a cross‐infection among personnel working in clinics or hospitals. Vesicles or bullae suggest the diagnosis; confirmation is by virus isolation. Eight cases in medical personnel whose duties included contact with the oral cavity of infected patients were seen within a period of 3 years. The disease started as a paronychia in 3 instances, but involvement of the pulp space was the rule. Radiating pain along the C7 distribution was noted in 4 patients. Numbness and hypoesthesia following the acute episode were observed in one patient. Two individuals suffered recurrent attacks of herpetic whitlow at the same site.
THE QUEENSLAND MELANOMA PROJECT
Authors: BEARDMORE GRAEME L.
Published: March 2008

The fate of over 1,500 patients treated for malignant melanoma in Queensland, Australia, between 1963 and 1969 has been followed by the Queensland Melanoma Project (QMP). Aspects which have been studied and reported include yearly incidence (16 per 100,000), sex incidence (females 55%, males 45%), size of melanomas (73% less than 2.0 cm), prognosis related to sex, site and histological features, multiple primary cutaneous melanomas (more than 1 in 4.8% of patients), hereditary and immunological aspects and value of frozen section diagnosis in management. Continued education of the public and medical practitioners is essential to insure early diagnosis and appropriate management of patients with melanoma.
PUSTULAR BLASTOMYCOSIS
Authors: HASHIMOTO KEN , KAPLAN ROBERT J. , DAMAN LAUREN A. , STUART JOHN M. , BERNHARDT HERMAN
Published: March 2008

A 53‐year‐old Negro man had North American blastomycosis with acute onset of widespread pustular eruptions. Several tests suggested that the patient might have had a deficiency of delayed hypersensitivity.
ROLE OF SOCIOCULTURAL AND ENVIRONMENTAL FACTORS IN THE CAUSE OF SCABIES
Authors: GULATI P.V. , SINGH K.P. , BRAGANZA C.
Published: March 2008

A house‐to‐house survey for scabies was done in a semiurban area with a population of 1727 from 273 families in 253 households, to study the sociocultural and environmental factors in families with scabies. It was found that sleeping habits, overcrowding for sleeping space and sharing of clothes, towel, etc, were significantly associated with scabies. There was no significant correlation between the size of family and the number of persons infected with scabies per family. The prevalence of scabies within the families was almost the same either with good hygiene, satisfactory hygiene or unsatisfactory hygiene. The factors significantly associated with the disease were observed to be more frequent among Christian families than among Hindus and were thought to be responsible for higher prevalence of the disease within the Christian families.
HYPHAL PRODUCTION BY PITYROSPORUM OVALE
Authors: CIVILA E. S. , VIGNALE R. , SANJIN?S A. , CONTI‐DIAZ I. A.
Published: March 2008

ABSTRACT: Pityrosporum ovale with abundant hyphae was found in 8 patients with lesions of the scalp and glabrous skin. It is thought that P. ovale in its mycelial form can produce lesions on seborrheic areas of the skin that probably represent a clinical form of tinea versicolor.
TREATMENT OF PSORIASIS: TRIOXALEN AND SUNLIGHT
Authors: SEHGAL V. N. , REGE V. L. , KHARANGATE V. N.
Published: March 2008

ABSTRACT: Eighteen psoriasis patients were treated alternately with 40 mg of trioxalen and sunlight on the right side and sunlight only on the left side. Improvement was apparent faster on the psoralen‐exposed side.
COMPARATIVE EFFECTIVENESS OF BENZOYL PEROXIDE AND TRETINOIN IN ACNE VULGARIS
Authors: LYONS ROBERT E.
Published: March 2008

ABSTRACT: A controlled, randomized clinical study comparing different commercially available benzoyl peroxide gels and tretinoin cream was undertaken by four investigators using similar protocols and case report forms. Results were based on lesion‐count reduction over an 8‐week period. No significant difference in reduction of total acne lesions was detected between the benzoyl peroxide gels and tretinoin cream. However, benzoyl peroxide was significantly better (P<02) in reduction of papules and as good as tretinoin in reduction of comedones. Results of this study suggest that excessive drying and peeling are not essential in the reduction of acne lesions.
CUTANEOUS MANIFESTATION OF INTERNAL MALIGNANCIES (I) ACANTHOSIS NIGRICANS
Authors: SAFAI BIJAN , GRANT JANE M. , KURTZ ROBERT , LIGHTDALE CHARLES J. , GOOD ROBERT A.
Published: March 2008

ABSTRACT: Skin changes may be the first clue to a neoplastic process at a stage when it still is treatable (Such as the development of Acanthosis Nigricans (AN) in an otherwise, healthy adult). Ninety percent of the neoplasms responsible for the development of AN originate in the abdomen. The tumor, even in a subclinical state, seems to possess unidentified properties that activate the dermatosis.
HEREDITARY SCLEROSING POIKILODERMA
Authors: GREER KENNETH E. , WEARY PEYTON E. , NAGY ROBERT , ROBINOW MEINHARD
Published: March 2008

ABSTRACT: Three persons with hereditary sclerosing poikiloderma were studied to find any clue to explain the mechanism involved in producing the cutaneous lesions which are so striking clinically and also evident histologically. Investigational studies included a blood chemistry screen, chromosome analyses, and skin biopsies evaluated by routine stains as well as by electron microscopy and direct immunofluorescence. No mechanism for the production of the clinical and histological changes in the dominantly inherited disorder was found.
THE PATTERN OF DISEASES OF THE SKIN IN THE NIGERIAN GUINEA SAVANNA
Authors: FEKETE ELIZABETH
Published: March 2008

ABSTRACT: Eight thousand and thirteen patients were seen in dermatological clinics at Kaduna and Zaria in the Northern guinea savanna of Nigeria. Fungal infections were found in 1,224 cases arid scabies in 923 cases, of which 765 patients had secondary infections. Similar results were found in other surveys from Sub‐Saharan Africa.
ANHIDROTIC ECTODERMAL DYSPLASIA
Authors: REDDY B. S. N. , CHANDRA SUSIL , JHA P. K. , SINGH GURMOHAN
Published: March 2008

ABSTRACT: Five patients with anhidrotic ectodermal dysplasia are reported from India.
CLINICAL AND LABORATORY EVALUATION OF 8‐METHOXYPSORALEN TOXICITY
Authors: MOFTY ABDEL‐MONEM EL , NADA MOHAMED N. , AZIZ MOHAMED T. ABDEL
Published: March 2008

ABSTRACT: Twenty‐seven patients with vitiligo took (Meladinine 8‐methoxypsoralen) for 2 to 12 years. They were selected from those patients who, in an attempt to get a more rapid repigmentary response, exceeded the advised doses by ingesting from 7–16 tablets (equivalent to 70–160 mg) per day. These regimens were well tolerated. Hepatic and renal function were not affected.
LICHEN PLANUS ACTINICUS
Authors: ZANCA ATTILIO , ZANCA ANDREA
Published: March 2008

Abstract: Two patients with lichen planus actinicus are reported. Lichen planus actinicus is more descriptive than lichen planus tropicus, since the condition appears in more temperate climate, i.e. Italy. The etiology of this condition is obscure, but light may act as a triggering mechanism.
ANETODERMA
Authors: MILLER WARREN N. , RUCCLES CHARLES W. , RIST TOIVO E.
Published: March 2008

ABSTRACT: Anetoderma is a rare cutaneous condition with characteristic, clinical features and histopathalogy. The condition is classified into idiopathic (Jadassohn or Pellizzari type) and atrophic (Schweinger‐Buzzi type) concomitant with other diseases, and secondary to infection or drugs.
HERPETIC WHITLOW
Authors: GIACOBETTI RICHARD
Published: March 2008

ABSTRACT: Three patients with herpetic whitlow are presented. Virus typing revealed herpes simplex virus type 1 in two and type 2 in one of the cases. There is a high risk of infection among medical personnel.
ACUTE ZINC DEPLETION SYNDROME DURING PARENTERAL HYPERALIMENTATION
Authors: STEGER JAMES W. , IZUNO GENE T.
Published: March 2008

ABSTRACT: Zinc is an essential trace element whose malabsorption in early childhood may result in a skin disorder known as acrodermatitis enteropathica. Cutaneous lesions typical of acrodermatitis enteropathica have been described during total parenteral nutrition on zinc‐deficient intravenous solutions in both adults and children. This condition has been named the “acute zinc depletion syndrome.” A case is described in which a patient, despite a zinc intake of double the daily requirement, manifested the acute zinc depletion syndrome during therapy with combined liquid diet plus parenteral hyperalimentation. Predisposing factors in this individual included a short bowel syndrome and a large oral load of calcium lactate. Zinc metabolism is reviewed with attention to alterations in disease and during hyperalimentation. The clinical manifestations, predisposing factors, therapy and prevention of the acute zinc depletion syndrome are discussed.
BENZOYL PEROXIDE GEL THERAPY IN ACNE IN SINGAPORE
Authors: YONG CHUAH CHONG
Published: March 2008

ABSTRACT: The results of an open clinical trial of 200 patients in Singapore show that benzoyl peroxide, in a stable gel formulation, both in 2.5% and 5% strengths, was highly efficacious in the topical treatment of acne vulgaris without con‐comitant systemic therapy. The series included a small number of Caucasians (13 patients) who were also treated effectively. Side effects noted were generally mild and transient.
THE COMBINED USE OF TOPICAL BENZOYL PEROXIDE AND TRETINOIN IN THE TREATMENT OF ACNE VULGARIS
Authors: HANDOJO INDRO
Published: March 2008

ABSTRACT: A clinical trial using tretinoin lotion 0.05%. benzoyl peroxide 5% and 10% as topical application was performed on 250 ambulatory patients suffering from various degrees of acne vulgaris. The results indicate that tretinoin applied in the morning and benzoyl peroxide applied at night is the most efficacious regimen to be used, with minimal side effects.
EFFECT OF FREQUENT SUN EXPOSURE ON BACTERIAL COLONIZATION OF SKIN
Authors: GERBER DIANE , MATHEWS‐ROTH MICHELINE , FAHLUND CHRISTINE , HUMMELL DOROTHY , ROSNER BERNARD
Published: March 2008

ABSTRACT: The bacteria colonizing the surface of the skin of a group of frequent sunbathers and a group of infrequent sunbathers were surveyed. Frequent sunbathing does not greatly affect the total number of organisms on the skin, but does tend to increase the proportion of bacteria containing carotenoid pigments.
VITILIGO TREATED WITH ACTH
Authors: HERNÁNDEZ‐PÉREZ ENRIQUE
Published: March 2008

ABSTRACT: Six of 20 patients with extensive vitiligo treated with ACTH experienced repigmentation at the end of 15 weeks. However, depigmentation recurred when the treatment was stopped.
THE TREATMENT OF DARIER'S DISEASE
Authors: CIPOLLARO VINCENT A. , SHAPS ROBERT
Published: March 2008

ABSTRACT: Radiation therapy of Darier's disease with both conventional x‐rays and Grenz rays has been advocated in the past. A comparison of the effects of x‐rays and Grenz rays in a typical case of Darier's disease showed some improvement with both qualities of ionizing radiation. The effects of x‐rays were superior to those of Grenz rays with improvement of more rapid onset and longer duration. However, spontaneous improvement noted in both treated and untreated areas demonstrates the difficulty in evaluating the benefits of ionizing radiation on Darier's disease. The authors do not recommend the use of radiation therapy in Darier's disease except in cases where a temporary anti‐inflammatory effect is desired.
EIXED DRUG ERUPTION
Authors: OLUMIDE YFTUNDE
Published: March 2008

ABSTRACT: Fixed drug eruption, a common finding in Lagos, was observed among patients being treated with two heavily promoted drugs: a pyrazolone anzlgesic and a benzodiazepine. Offending drugs should be considered in general classes rather than as individual compounds.
SERUM ATYPICAL PSEUDOCHOLINESTERASE AND LEPROSY
Authors: NAVARRETE J. I. , LISKER R. , PÈREZ‐BRICEÑO R.
Published: March 2008

ABSTRACT: The frequency of the serum atypical pseudocholinesterase variant was significantly higher (p < 0.005) in a group of 115 lepromatous leprosy patients than in a comparison group of 133 healthy individuals. This finding corroborates the results obtained in the group of patients from India, and supports the contention that the serum atypical pseudocholinesterase is one of the possible genetic factors involved in susceptibility to leprosy.
IMMUNOLOGIC AND GASTROINTESTINAL ABNORMALITIES IN DERMATITIS HERPETIFORMIS
Authors: THUNE P. , HUSBY C. , FAUSA O. , GEDDE‐DAHL D. , BAKLIEN K. , SOLHEIM B.
Published: March 2008

ABSTRACT: Eighty patients with untreated dermatitis herpetiformis (DH) were studied. The final diagnosis was made after completion of immunofluorescence (IF) studies of the skin, iodine provocation tests and gastrointestinal investigations. IgA deposits in the skin and the HLA‐DRw3 B‐cell alloantigen can be demonstrated in nearly all cases of DH. Positive iodine provocation test and gastrointestinal abnormalities are present in about 78% of the cases. For diagnostic purposes tissue typing and intestinal biopsy is of value in addition to IF studies of the skin.
ZOSTERIFORM INFLAMMATORY METASTATIC CARCINOMA
Authors: HODGE STEVEN J. , MACKEL SUSAN , OWEN LAFAYETTE G.
Published: March 2008

ABSTRACT: A 57‐year‐old man presented with chest wall lesions and swelling of his left arm. The rapid onset of vesicular lesions in a dermatomal distribution resulted in an initial diagnosis of herpes zoster. Cutaneous biopsy revealed adenocarcinoma and further evaluation revealed a primary source of pulmonary adenocarcinoma. Lymphatic spread of tumor cells is the most likely source of the zosteriform skin lesions, but other possibilities are discussed.
SUBCUTANEOUS CHROMOMYCOTIC ABSCESSES CAUSED BY PHILAOPHORA GOUGEROTII
Authors: KOTRAJARAS RENOO , CHONGSATHIEN S.
Published: March 2008

ABSTRACT: Subcutaneous chromomycotic absesses due to phialophora gougerotti in a 50‐year‐old woman were characterized by subcutaneous abscesses adhering together through fistulous tracts, rupturing and leaving black crusts. Over multiple sinuses mimicking mycetoma. Reinfection occurred in contaminated excised lesions. Intradermal inoculation in different anemic patients caused abscesses in 14 days and healed without therapy in eight weeks. No spreading to other organs was found after intraperitoneal inoculation of mice for eight weeks.
ULTRAVIOLET PHOTOTHERAPY OF UREMIC PRURITUS
Authors: GILCHREST BARBARA A.
Published: March 2008

ABSTRACT: Repeated exposure to mid‐range ultraviolet light (UVB) can dramatically relieve the pruritus associated with uremia. The efficacy of UVB phototherapy uremic pruritus has been established it a controlled trial; experience with 38 patients suggests that 80 to 90% of those receiving 6 to 8 exposures respond favorably within the treatment period U to 5 weeks). Treatment frequency appears not to influence the remission rate, although patients on more intensive schedules experience relief sooner than those treated once weekly. Remissions are long‐lasting in many patients, sometimes longer than 2 years. Patients with recurrent pruritus respond to phototherapy at least as well as previously untreated patients and tend to improve more rapidly. UVB phototherapy appears to exert beneficial effect systemically rather than locally, but its mechanism of action is otherwise unknown.
THESIS REVIEW
Authors: MAIBACH HOWARD I.
Published: March 2008

Thesis review in this article:

TINEA VERSICOLOR AND PITYROSPORUM ORBICULARE: MYCOLOGICAL INVESTIGATIONS, EXPERIMENTAL INFECTIONS AND EPIDEMIOLOGICAL SURVEYS. Jan Faergemann, M.D.
BOOK REVIEWS
Authors: BEERMAN HERMAN
Published: March 2008

Book reviews in this article:

THE EPIDEMIOLOGY OE HUMAN PEDICULOSIS IN ETHIOPIA. L. L. Sholdt, M. L. Holloway, W. D. Fonk.

DERMATOLOGY. Hans Rorsman. Second Edition

TUBEROUS SCLEROSIS Manuel R. Gomez, M.D.

DERMATOLOGY UPDATE: REVIEWS EOR PHYSICIANS, 1979 EDITION. Samuel L. Moschella, M.D., Editor in Chief.
Actinic Reticuloid
Authors: Guardiola Armando , Sánchez Jorge L.
Published: March 2008

ABSTRACT: We report four cases of actinic reticuloid, including the first case ever reported in a woman. We have concluded that not all the patients are persistent light reactors and that the histologic presentation can be quite variable, in some cases extremely difficult to differentiate from a cutaneous lymphoma. Phototesting studies incriminate the long UV and/or visible light range. The duration of the disease in these cases suggests a benign process which can be included among the cutaneous pseudomalignancies. Further cytoimmunological studies may incriminate the interaction of T‐lymphocytes in the pathogenesis of the condition.
Phenol Chemosurgery for Removal of Deep Facial Wrinkles
Authors: Gross B. G. , Maschek Francis
Published: March 2008

ABSTRACT: The derivation of the different phenol formulas for facial rejuvenation is traced. The method of action of phenol and the formula additives is discussed and an improved technique is described with which deep as well as superficial wrinkles of the face can be removed. Phenol chemosurgery is a proper alternative to the surgical face lift in properly selected patients. The potential complications of the procedure should not detract from the benefits.
Book Reviews
Authors: BEERMAN HERMAN
Published: March 2008

Book reviews in this article:

CLINICAL METHODS IN DERMATOLOGY AND VENEREOLOGY. 2nd ed. J. S. Pasricha.

THE 1979 YEAR BOOK OF DERMATOLOGY. Richard L. Dobson, M.D.

GENETIC DISORDERS AMONG THE JEWISH PEOPLE. Richard M. Goodman

THE GENETICS OF THE JEWS. A. E. Mourant, A. C. Kopeć and K. Domaniewska‐Sobczak.
Liver Biopsies in Psoriatics Complications and Evaluation
Authors: Creswell S. N. , Burrows D.
Published: March 2008

ABSTRACT: Thirty‐one liver biopsies were performed on twenty‐two psoriatics on treatment or considered for treatment with methotrexate. Three developed serious morbidity after biopsy. Of twenty‐one attempted pre‐methotrexate biopsies, four were abnormal, and one failed. Five of ten post‐methotrexate biopsies were abnormal. Histological abnormalities were mild and cirrhosis was not seen.

Liver function tests were not found to be a reliable indicator of hepatic damage and it is felt that in spite of our relatively high complication rate, liver biopsy is a useful method for monitoring liver damage due to methotrexate and should be performed.
BOOK REVIEWS
Authors: BEERMAN HERMAN
Published: March 2008

Book reviews in this article:

OFFICE TECHNIQUES FOR DIAGNOSING SKIN DISEASE. William H. Eaglstein, David M. Pariser.

GENETIC DISEASES OF THE SKIN. V. M. Der Kaloustian and A. K. Kurban.

TECHNIQUES IN SKIN SURGERY. Ervin Epstein and Ervin Epstein, Jr.

MORPHOLOGICAL DERMATOLOGY. Robert Jackson, M.D.

LEPROSY. Anthony Bryceson and Roy E. Pfaltzgraff.
BOOK REVIEWS
Authors: BEERMAN HERMAN
Published: March 2008

Book review in this article:

TEXTBOOK OF DERMATOLOGY. Arthur Rook, D. S, Wilkinson and F. J. G. Ebling
Cutaneous Toxoplasmosis
Authors: Binazzi Maurizio , Papini Manuela
Published: March 2008

ABSTRACT: Nine patients with cutaneous toxoplasmosis had slowly regressing erythema‐multiforme‐like eruptions or lichenold, papulonodular and purpurictelangiectatic disorders. The most common histologic finding was subacute histio‐lymphocytic perivasculitis with frequent demonstration of the parasite. Another group of patients showed similar clinical and histological findings, but the parasite was not evidenced in these.
Treatment of Multiple Viral Warts with Levamisole
Authors: Saúl Amado , Sanz Rosario , Gomez Martha
Published: March 2008

ABSTRACT: Seventy‐seven patients with multiple common warts were screened for a double‐blind study using levamisole. Of these, only 32 patients showed cellular immune deficiency. Fourteen patients received 2.5 mg/kg, two days a week, for eight weeks, and eighteen received a placebo. Both groups showed some improvement but results were not statistically different. Placebo plays a significant role in the treatment of warts.
Book Reviews
Authors: BEERMAN HERMAN
Published: March 2008

Book reviews in this article:

SKIN CARCINOGENESIS. Michel Prunieras, Editor

INTERNAL MEDICINE IN VIETNAM. Skin Diseases in Vietnam, 1964–72. Alfred M. Allen.
Epidermodysplasia Verruciformis (Lewandowsky‐Lutz):
Authors: Arnold Harry L.
Published: March 2008

ABSTRACT: A Japanese girl, born of a consanguineous marriage, believed to have epidermodysplasia verruciformis, lost all of her wart‐like lesions within a week after one was biopsied, and was then considered to have actually just had warts. It was only in retrospect, years afterward, that it was realized that the truly wart‐like nature of the lesions did not exclude epidermodysplasia verruciformis at all. The case is therefore being belatedly reported, as a reminiscence.
Involvement of the Digestive Tract in Cowden's Disease
Authors: Ortonne J. P. , Lambert R. , Daudit J. , Berthet P. , Glanadda E.
Published: March 2008

ABSTRACT: A 28‐year‐old white man had Cowden's disease and multiple gastrointestinal polyps. Of the 56 cases of Cow‐den's disease which have been reported so far, esophageal and gastrointestinal involvement have been observed in only 18 patients. Endoscopic, radiologic, and histopathologic features of these lesions were confirmed in the present patients.
Pityriasis Rosea in Nigerians
Authors: Jacyk Witold K.
Published: March 2008

ABSTRACT: One hundred thirty‐eight Nigerian patients with pityriasis rosea were studied. Patients with the condition constituting 2.4% of all patients seen in two skin clinics in Northern Nigeria in a period of over three years. The proportional rate of pityriasis rosea parallels figures from other African studies, and is higher than values obtained in European series. Pityriasis rosea in Nigerians appears to be more florid and has a greater tendency to overstep the classic boundaries of distribution on the body, to affect the face and involve the oral cavity. The sex and age distribution was similar to European series, although some lowering of the age of onset of the condition was observed. No relationship between the frequency of pityriasis rosea and season was found.
Dermatophyte Infection of the Penis
Authors: Pandev S. S. , Chandra S. , Guha P. K. , Kaur P. , Singh G.
Published: March 2008

ABSTRACT: Penile involvement was seen in 19.5% of 261 patients, aged 11 to 30 years, with tinea cruris. It was more common in patients under the age of (20 years (p < 0.05). The increased incidence is probably related to the use of langota. a semiocclusive undergarment that may favor the growth of dermatophytes.
Multiple Cutaneous Granular Cell Tumors Simulating Prurigo Nodularis
Authors: Noppakun Nopadon , Apisarnthanarax Prapand
Published: March 2008

ABSTRACT: A 37‐year‐old black man with 64 pruritic cutaneous granular cell tumors represents the highest number of such lesions ever reported. The clinical resemblance to prurigo nodularis are the unique features. Partial response to intralesional corticosteroid injection is noted.
Study of Dermatomycoses
Authors: Khosa R. K. , Girgla H. S. , Hajini G. H. , Sharma B. M. , Singh G. M.
Published: March 2008

ABSTRACT: 555 clinically suspected cases of dermatomycoses were studied for causative fungi and their detailed clinical manifestations. The fungi were demonstrated on routine KOH mount and/or by culture in 464 cases (83.6%). Tinea corporis was the predominant fungal infection (30.6%) and T. rubrum was the main etiologic agent. Favus (T. schoenleini) was found only in cases from Jammu and Kashmir valleys. There was a high incidence of tinea capitis among children. Trichophyton tonsurans was isolated in cases of tinea corporis, tinea cruris, and tinea pedis. Trichophyton ferrugineum and T. verrucosum were isolated from cases of tinea capitis; and Microsporum gypseum was isolated from tinea cruris infections.
Topical Tetracycline Hydrochloride vs. Topical Clindamycin Phosphate in the Treatment of Acne
Authors: Steven Padilla R. , Mccabe Jack M. , Becker Larry E.
Published: March 2008

ABSTRACT: In a comparative study of topical antibiotic solutions, clindamycin phosphate vs. tetracycline hydrochloride for the treatment of mild to moderate inflammatory facial acne, clindamycin phosphate solution proved to be a superior agent in the reduction of papules and pustule. Both preparations had minimal side effects.
Persistent Cutaneous Herpes Simplex Infection
Authors: Burkhart Craig G.
Published: March 2008

ABSTRACT: A 38‐year‐old, renal transplant patient developed painful, extensive, chancre‐like genital ulcerations. The etiological agent was found culturally to be herpes virus type II. The eruption lasted five months and proved recalcitrant to standard therapeutic modalities. On removal of the transplanted kidney and thereby reduction of immunosuppressive agents, the cutaneous viral infection cleared rapidly. The potential severity and persistence of cutaneous herpetic infections in renal transplant patient must be well appreciated or the diagnosis might easily be missed.
Plantar and Palmar Hyperkeratosis in Young Castrated Women
Authors: Wachtel Tom J.
Published: March 2008

ABSTRACT: Three cases of palmar and plantar hyperkeratosis were observed in young women following bilateral oophorectomy. We found this condition, previously described as keratoderma climactericum, to be completely reversible with estrogen replacement therapy. In patients with hysterectomy in addition to oophorectomy, the major risk of estrogen administration, endometrial cancer, does not apply.
Treatment of Acne Vulgaris with Topical Clindamycin Phosphate: A Double‐Blind Study
Authors: Guin Jere D.
Published: March 2008

ABSTRACT: In a double‐blind study, 1% clindamycin phosphate in aqueous‐alcohol vehicle was compared with the vehicle alone on the opposite side. Of 29 patients evaluated, the clindamycin‐treated side was found to be better in 11, the placebo side was better in four, and both sides were improved in five. No benefit was found in the remaining nine patients. These results were not considered statistically significant. Following discontinuance of treatment a prominent flare was noted in 14 of 19 patients who had previously improved on one side or the other, and this was considered significant (p < .05). One percent clindamycin phosphate in equal parts of alcohol and water is apparently beneficial for some, but not for all patients with inflammatory acne.
Juvenile Xanthogranuloma in a Child with Insulin‐dependent Diabetes Mellitus
Authors: Cinsberg‐Fellner Fredda , Fellner Michael J.
Published: March 2008

ABSTRACT: A young girl who developed classical insulin‐dependent diabetes mellitus at one year of age also developed carotinemia and a typical picture of juvenile xanthogranuloma beginning at five months of age which exhibited A waxing and waning courses. When her diabetes was well‐controlled, her serum lipid levels were within normal limits. This is the first reported association of diabetes mellitus and juvenile xanthogranuloma, which together with previous reports of eye, cardiac, pulmonary, and posterior pituitary involvement in children with juvenile xanthogranuloma, suggests that the rare organ involvement in this disease, as well as the characteristic skin lesions, could result from similar etiologic factors which still remain to be elucidated.
Rifampicin Treatment of Cutaneous Leishmaniasis
Authors: Even‐Paz Zvi , Weinrauch Louis , Livshin Rita , El‐On Joseph , Leonard Greenblatt Charles
Published: March 2008

ABSTRACT: In a small‐scale preliminary trial of oral rifampicin treatment was considered successful in six out of eight cutaneous leishmaniasis patients and probably effective in a seventh. The in vitro effect of rifampicin on leishmania organisms concerns inhibition of mitochondrial function or replication. The need for protozoological control in the assessment of treatment is stressed.
Histologic Observations of Coccoid Forms Suggestive of Cell Wall Deficient Bacteria in Cutaneous and Systemic Lupus Erythematosus
Authors: Cantwell Alan R. , Kelso Dan W. , Jones Joyce E.
Published: March 2008

ABSTRACT: The cutaneous lesions of seven consecutive patients with cutaneous lupus erythematosus (LE), two patients with systemic LE, and a patient with both dermatomyositis and cutaneous LE, were studied bacteriologically and microscopically for the presence of bacteria. The study was prompted by the previous reports of variably acid‐fast and non‐acid‐fast bacteria in other collagen diseases, and also by recent reports confirming the presence of cell wall deficient (CWD) bacteria (staphylococci, streptococci, and corynebacteria) within the hematologic elements of both “normal” and diseased individuals. Staphylococcus epidermis was isolated from four cases, Propionibacterium acnes from two cases, and Corynebacterium sp. from one case. Three cases were bacteriologically negative. Basophilic and eosinophilic‐stained coccoid forms, suggestive of CWD bacteria, were identified in the microscopic sections of all the cases, as were non‐acid‐fast coccoid forms. Definite acid‐fast coccoid forms were observed in vivo in two cases of cutaneous LE. The complex bacteriology of LE is discussed, as well as the possibility that variably acid‐fast CWD microbes might be the long sought‐after etiologic agent or agents in the production of LE.
Bullous Pemphigoid and Ulcerative Colitis
Authors: Razzaque Ahmed A. , Kaplan Richard P. , Hardy David , Feldman Edward , Pitt Henry
Published: March 2008

ABSTRACT: A 21‐year‐old white woman, who had ulcerative colitis for 14 years, developed generalized severe bullous pemphigoid. Following the resection of her colon, her skin showed marked clinical improvement, but this was only temporary. Direct immunofluorescence was performed on the surgical specimen and no antibodies (BMZ) to colonic mucosal cells were evident. Anti‐basement membrane zone antibodies were found on direct and indirect immunofluorescent studies and have persisted. Sera from 15 patients with ulcerative colitis and 11 patients with Crohn's disease, evaluated for the presence of an anti‐basement membrane zone antibody did not contain any demonstrable levels of anti‐BMZ antibodies. The co‐existence of ulcerative colitis and bullous pemphigoid is more likely incidental rather than etiopathologic.
Improved Methods for Office Fungal Culture
Authors: Gip Lennart
Published: March 2008

ABSTRACT: A new screening culture method which can be used as an office fungal culture involves a microculture, where a selective medium (DTM) is used for coating a thin transparent plastic slide. Sampling is performed with a transparent adhesive tape which is pressed on to the surface of the agar and allows daily microscopic examination of the culture. Identification of the fungus is based on its micromorphologic features and possible color change of the substrate. Growth of dermatophytes and Candida usually can be detected and registered within 48 hours. The screening method is simple to handle and read and may be monitored by inexperienced personnel with virtually no microbiologic knowledge.
A Single Application of Crotamiton Lotion in the Treatment of Patients with Pediculosis Capitis
Authors: Karacic I. , Yawalkar S.J.
Published: March 2008

ABSTRACT: A single application of 10% crotamiton lotion cured 96% of the 49 patients treated for pediculosis capitis. Only two (4%) patients needed a second application. Following crotamiton application, pruritus regressed completely in 98% of the patients. An adverse effect, namely localized skin irritation leading to interruption of the trial treatment, was reported in one patient.
Diagnosis of Neurotic Excoriations
Authors: Fruensgaard Kjeld , Hjortshøj Anders
Published: March 2008

The diagnosis of neurotic excoriations (n.ex.) is evaluated on the background of a multifactorial controlled investigation, covering 68 patients with the primary form of this disease. Demographic, dermatologic, and clinical psychiatric characteristics of n.ex. may be exclusive but in far the greatest number of cases can only be recognized by “broad‐spectrum” evaluation of anamnestic and clinical data. Patch testing seems to be the most relevant supplementary laboratory test, while determination of IgE in serum can have a directive value.
Bachelor Scurvy
Authors: Connelly Thomas J. , Becker Andera , McDonald John W.
Published: March 2008

Scurvy occurred in an elderly man with fatigue, dyspnea on exertion, and extensive ecchymoses and brawny edema of the legs. Platelet count, prothrombin time, and partial thromboplasm time were normal, but serum ascorbic acid level was very low. Other signs considered to be classic and almost pathognomonic for were absent: bleeding gums, hyperkeratotic follicles, coiled hairs, and perifollicular hermorrhages. Reliance on these well‐known feature of scurvy may obscure or delay diagnosis of an easily curved disorder. Severe scurvy is most commonly suggested by tenderness, extensive ecchymoses, and brawny edema of the lower extremities.
8‐Methoxypsoralen‐Induced Nail Pigmentation
Authors: Naik R. P. C. , Pakameswara Y.R.
Published: March 2008

Ten psoriatic patients taking 8‐methoxypsoralen and sunlight exposure (PUVASOL). were observed for changes in the nails. Three patients developed nail pigmentation.
Book Reviews
Authors: BEERMAN HERMAN
Published: March 2008

Book reviews in this article:

PEDIATRIC DERMATOLOGY—NEW DIRECTIONS IN THERAPY. William P. Coleman III and Elizabeth I. McBurney.

RECENT ADVANCES IN DERMATOLOGY—NUMBER 5. Arthur Rook and John Savin, Editors.

MANUAL OF DERMATOLOGY: AN INTRODUCTION TO DIAGNOSIS AND TREATMENT. Jeffrey P. Callen, Marek A. Stawiski, and John J. Voorhees, with a foreword by Walter B. Shelley.

EXPERIMENTAL SKIN GRAETS AND TRANSPLANTATION IMMUNITY. Donald L. Ballantyne and John Marquis Converse.

DERMATOLOGY: PROCEEDINGS OE THE XV INTERNATIONAL CONGRESS OE DERMATOLOGY. Antonio Gonzalez‐Ochoa, Luciano Dominguez‐Soto, Yolanda Ortiz, eds.

HOW TO WRITE AND PUBLISH A SCIENTIEIC PAPER. Robert A. Day.

CURRENT MEDICAL DIAGNOSIS AND TREATMENT. M. A. Krupp, M.D., and M. J. Chatton, M.D.
Cutaneous Complications during Measles in Zairian Children
Authors: Koźmińska‐Kubarska A. , Talletrand D. , Bakatubia Mvita
Published: March 2008

ABSTRACT: Thirty‐eight children with postmeasles peribuccal, perinasal, and periorbicular lesions, mostly ulcerative character in nature, were analyzed and a comparison between the noma and the observed lesions was performed. Noma‐like postmeasles ulcerations is the preferred name.
Scabies in the Extended Care Facility
Authors: Parish Lawrence Charles , Millikan Larry E. , Witkowski Joseph A. , Schwartzman Robert
Published: March 2008

ABSTRACT: Scabies occurred in three nursing homes (two in Missouri and one in Pennsylvania) where the diagnosis was obscured by a lack of the usual clinical signs. Topical steroids can aggravate scabies and help to confirm the diagnosis; treatment with lindane lotion is successful, provided all patients and health personnel are treated.
Reactive Perforating Collagenosis in the Setting of Prurigo Nodularis
Authors: Henry John C. , Jorizzo Joseph L. , Apisarnthanarax Prapand
Published: March 2008

ABSTRACT: A 33‐year‐old Korean woman developed reactive perforating collagenosis in adulthood. Initially, her lesions resembled prurigo nodularis rather than umbilicated keratotic papules.
Prognostic Implications of Cutaneous Immunoglobulin Deposits In Systemic Lupus Erythematosus
Authors: Bernstein Joel E. , Soltani Keyoumars , Cristancho Nersa , Aronson Andrew J.
Published: March 2008

The class of immunoglobulin (Ig) deposited at the dermal‐epidermal junction (DEI) of the skin in patients With systemic lupus erythematosus (SLE) has been proposed to have prognostic implications. The authors studied disease activity in 51 SLE patients with a positive lupus band. Patients with cutaneous IgM deposits had significantly more severe disease than those with only IgG or with mixed immunoglobulin deposits. While their data suggest an association between IgM depostis, severe disease and a poor prognosis, they urge caution in utilizing Ig deposits as a prognostic indicator.
Pellagra Probably Due to Pyrazinamide: Development during Combined Chemotherapy of Tuberculosis
Authors: Jørgensen Jørgen
Published: March 2008

Pellagra secondary to antituherculous chemotherapy can result from isoniazide therapy, as well as from pyrazinamide treatment. Because of the similarity in strucutral formulas between pyrazinamide, isoniazide, and nicotinamide, the substrate competition is the mechanism most likely involved. The patient was cured by administration of nicotinamide during continued unchanged chemotherapy of her tuberculosis.
A Surgical Approach for Dermatosis Papulosa Nigra
Authors: Kauh Young C. , McDonald John W. , Rapaport Jeffrey A. , Ruschak Paul J. , Luscombe Herbert A.
Published: March 2008

Dermatosis papulosa nigra (DPN) is a disorder commonly encountered in the adult black population. We describe 20 cases of clinicopathologically confirmed DPN cases treated with light abrasive curettage without local anesthesia. We found this procedure to be an effective therapy, which did not cause postoperative scarring or significant postoperative pigmentary change.
Scabies and Systemic Lupus Erythematosus
Authors: Ting H. C. , Wang F.
Published: March 2008

There is little information in the literature concerning scabies in patients with systemic lupus erythematosus. Scabies in our five patients appeared to be more severe than usual, and two of them developed crusted scabies, probably on an immunologic basis.
Reproducibility of Clinical Trials of Topical Glucocorticosteroids
Authors: Fredriksson Torsten , Lassus Allan , Salde Lars
Published: March 2008

Clinical trials of topical glucocorticosteroids employ a variety of evaluating methods. This makes it difficult to assess the relative strengths of the products without resorting to direct comparative trials between them. We propose a standardized evaluation system for this class of pharmaceuticals that can easily be adopted by any competent dermatologist. Its use would facilitate evaluation of new topical glucocorticosteroids.
The Effect of Antihistamines on Ultraviolet‐Light–Induced Erythema
Authors: Edwards E. K. , Edwards E. K.
Published: March 2008

Because of the possible role of histamine as an early mediator of ultraviolet light induced erythema, we studied a group of volunteers treated with both HI and H2 blockers, alone and in combination, before and at various time intervals after, UVL irradiation. No difference was found in the degree of erythema produced by any of the antihistamines used, whether alone or in combination, when compared with the saline control.
Fibrin Deposits and Fibrinolytic Activity in Schonlein‐Henoch Syndrome
Authors: Bianchini Gastone , Lotti Torello , Fabbri Paolo
Published: March 2008

ABSTRACT: Previous, reports have shown that alterations in cutaneous and plasmatic fibrinolytic activity are found in cutaneous necrotizing vasculitis (CNV). In a combined investigation with direct immunofluorescence and autohistographic evaluation of tissue fibrinolytic activity in the lesional skin of 20 subjects affected by Schonlein‐Henoch (SH) syndrome, there was a marked decrease in cutaneous fibrinolytic activity in SH syndrome accompanied by deposits of fibrin‐like material at the dermo‐epidermal junction and around the small blood vessels of dermis in affected skin. These data suggest some interactions between decreased fibrinolytic activity, fibrin deposits, and the tissue damage in the development of skin changes in SH syndrome.
Dermatophytic Infection of the Scalp in the Region of Butare (Rwanda)
Authors: Buginco Codefroid
Published: March 2008

ABSTRACT: We examined samples of hairs taken from 60 children presenting with the clinical picture of tinea capitis. In 53 cases, direct microscopic examination showed either ectothrix or endothrix parasitism, and we were able to grow the causative dermatophyte. We had 34 strains of Trichophyton violaceum, 19 of Microsporom langeroni, and two of Trichophyton verrucosum. The latter is found for the first time in this region to be a cause of ringworm in humans.
Generalized Cutaneous Mastocytosis and Acute Myelogenous Leukemia
Authors: Shaw Daniel W. , Hocking William , Ahmed A. Razzaque
Published: March 2008

ABSTRACT: A 64‐year‐old white man presented with a two‐month history of asymptomatic generalized cutaneous mastocytosis. Nine months later, he developed acute myelomonocytic leukemia.
Cutaneous Changes in Huntington's Disease
Authors: Witkowski Joseph A. , Charles Parish Lawrence , Gray Wood Margarei
Published: March 2008

ABSTRACT: The histologic findings of the skin of patients with Huntington's disease include hyperkeratosis, epidermal atrophy, subepidermal fibrosis, and an increase in acid mucopolysaccharide. Obvious macroscopic cutaneous changes are not present.
Cutaneous Immunofluorescence Studies to Adult Rheumatoid Arthritis in Sun‐exposed and Non‐sun‐exposed Areas
Authors: MA Alice S. P. , Soltani Keyoumars , Bristol Lynn A. , Bernstein Joel E. , Sorensen Leif B.
Published: March 2008

ABSTRACT: The incidence and significance of positive cutaneous immunofluorescence findings were assessed in biopsy specimens of both sun‐exposed and non‐sun‐exposed skin of 34 adult patients with rheumatoid arthritis (RA) who were not receiving systemic corticosteroids. The incidence of lupus erythomatosus (LE)‐band was low (8.6%) in both groups. Twenty‐eight percent of the patients had perivascular IgM and lor C3 deposits, and 74% had cytoid bodies in the papillary dermis. These studies indicate that the incidence of LE band is low in RA and that the detection of such a band in normal skin warrants close follow‐up of RA patients for possible development of LE.
Pathology of Granulomatous Diseases, Epithelioid Granulomas, Part II
Authors: Hirsh Bernard C. , Johnson Waine C.
Published: March 2008

Although many of the disease processes classified under group 1, epithelioid granulomas, result from diverse etiologic agents, they share a common microscopic tissue morphology of relatively well‐organized granulomas containing large numbers of epithelioid cells.
Quantitative Culture of Pityrosporon Orbiculare
Authors: Faergemann Jan
Published: March 2008

The author describes for the first time a method to culture Pityrosporon orbiculare quantitatively. Different nonionic detergents were studied for their in vitro effect to minimize aggregation of P. orbiculare. Triton X‐100 0.1% had only a slight inhibitory effect when the organism was held less than 2 hours. A critical point in quantitative culturing of P. orbiculare seems to be the medium. With this medium, solitary colonies and optimal growth are achieved. No statistically significant differences were found in quantitative cultures from lesions and normal skin in patients with tinea versicolor, but this was observed when quantitative cultures from lesions and normal skin in patients with tinea versicolor were compared with healthy controls.
Cutaneous Coccidioidomycosis Simulating Lepromatous Leprosy
Authors: Hobbs Edmund R. , Hempstead Richard W.
Published: March 2008

Leprosy has the reputation of a simulator of other diseases in clinical medicine. Conversely, leprosy has nondiagnostic but characteristic clinical features that may be imitated on occasion by other diseases. Recently, a patient with an appearance compatible with the clinical diagnosis of lepromatous leprosy was found to have a peculiar manifestation of disseminated coccidioidomycosis.
Treatment of Leprosy with Weekly Intravenous, Infusion of Leukocytes
Authors: Martinez Maria I. , Sánchez Jorge L.
Published: March 2008

Two patients with lepromatous leprosy were treated with weekly intra‐venous intuitions of leukocyte concentrates for A period of 12 consecutive weeks. A reversal reaction was induced in one of the patients, and it was possible to control chronic erythema nodosum leprosum in the other subject. Possible pathogenetic mechanisms involved in the induction of these changes include the action of transfer factor, interactions between B‐and T‐lymphocytes or the mediation of lymphokine necessary for the effective function of the cell‐mediated immunity. Immunotherapy for chronic infections, such as leprosy, still has not become a reality.
Recurrent Granulomatous Dermatitis with Eosinophilia
Authors: Mitchell Andrew J. , Anderson Thomas F. , Headington John T. , Rasmussen James E.
Published: March 2008

ABSTRACT: A 27‐year‐old woman developed a chronic, recurrent eruption of the face and upper extremities with the clinical and histopathologic features of recurrent granulomatous dermatitis with eosinophilia (Wells'syndrome). As described in 15 previously reported cases, this disorder is characterized by two clinical phases (ensinophilic cellulitis and granuloniatou plaque phase) and three histopathologic stages. The latter are particularly remarkable for a diffuse dermal and subcutaneous eosinophilia in acute lesions and scattered flame figures in chronic lesions. Distinctive findings in this case were the predominance of facial involvement and the symptomatic response to topical corticosteroids. Although etiology and pathogenesis are unknown, we feel that Wells'syndrome is a unique yet rarely recognized clinicopathologic entity.
Treatment of Superficial and Deep‐seated Mycoses with Oral Ketoconazole
Authors: Conti‐Diaz Ismael A. , Clvlla Eduardo , Asconfgui Felipe
Published: March 2008

ABSTRACT: Oral ketoconazole was given to 50 patients, 36 with superficial and 14 with deep‐seated mycoses. Satisfactory results were obtained in dermatophytoses, pityriasis versicolor, and chronic mucocutaneous candidiasis. Paracoccidioidomycosis also responded well to ketoconazole therapy. The authors'experience in patients with histoplasmosis and aspergil‐losis does not make it possible to express a firm view on the efficacy of the drug. Ketoconazole is not the recommended drug for treatment of sporotrichosis.
Bacteriology and Acne
Authors: Charles Parish Lawrence , Witkowski Joseph A.
Published: March 2008

Were we to discuss the cause of acne a hundred years ago, it would be quite simple. Louis Duhring, Pathfinder for American Dermatology, considered the etiologies of acne. They “are numerous and are very different in their nature…. The most frequent and ordinary origin of acne is puberty…. [the] general disability of the system occupies a conspicuous place. Under this head may be grouped all those abnormal conditions arising from imperfect physical development, improper nutrition, and other defects of the economy, whether organic or functional.” So much for the 19th century.