bluuebunny/crossref_metadata_2025 huggingface dataset:
Social Health, Social Pressure, and Social Immunity
Authors: Pilyushenko Alexandra
Published: July 2021

The article addresses the problem of social health as a basic factor of positive sociocultural environment in the context of globalization. The research objective was to define the content of social health as a balance of such categories as social immunity and social pressure. The study relied on the methodology of philosophical analysis, dialectical method, and system approach. The phenomenon of social health was described as part of the system of dynamic and multidimensional social relations. The article featured the role of sociocultural environment of one's life and attitudes of spiritual and moral nature that make up one's social health formation. Social pressure is an attributive characteristic of social life, which is getting increasingly complex in all areas of human life. The article also introduces the term of social immunity as a set of spiritual foundations of one's activity that provides one with productive social relationships. Social immunity depends on one's age, lifestyle, and sociocultural environment. The author also analyzed various prosocial deviant forms of behavior. The decisive factor of social health formation is that social immunity should correspond with the current social pressure.
Anti-Russian Sanctions as a Prerequisite for Expanding International Scientific and Technical Cooperation with Asian Countries
Authors: Anichkin Eugene , Rezinkin Alexey
Published: July 2021

The article describes the international scientific and technical cooperation (ISTC) of the Russian Federation with foreign states in the context of the anti-Russian sanctions. The research featured the political and economic anti-Russian sanctions that define the current cooperation in the scientific and technical field. The authors described the phenomenon of sanctions, their main types, reasons, specific features, etc., putting stress on the industrial and selective character, as well as on their indirect influence on Russian ISTC. There are no scientific and technological sanctions per se; however, the current political and economic sanctions keep affecting the ISTC sphere, e.g. inability to purchase and deliver reagents and high-tech equipment, to accept financing from foreign funds, etc. The sanctions manifest themselves as narrow scope of research projects, low academic mobility, etc. The two areas with appropriate mechanisms to counter the sanctions policy are political and legal. For instance, a diversified state policy could be developed to support ISTC. Public scientific diplomacy and an official vector of development might be of great help, in particular, the Asian vector of ISTC development. The authors believe ISTC should take place between the members of the Shanghai Cooperation Organization. The legal counteraction mechanisms include issuing normative legal acts, suspension of international agreements in ISTC, counter-sanctions, and international arbitration.
Specifics of Legal Regulation of Property Relations of Minor Family Members
Authors: Voronina Svetlana
Published: July 2021

he present research considered the property rights of minors by comparing civil and family legislation. The article covers various matters of separate ownership of parents and children, property management, and the behavior of parents, as well as sectoral and inter-sectoral legal relations as a whole based on family relations. The research was based on normative legal acts, scientific publications, and precedents. Family law regulates the property relations between parents and children regarding the maintenance and personal belongings. Any other property rights of minors fixed by the Family Code go beyond the limits of family law and are part of civil law. The basis of civil property relations of minors is the family relations. Therefore, they have to take into account social and legal relations between parents and children. A prerequisite for the emergence and implementation of property relations is the organizational relations that arise between the subjects of private and public law. Authorization by the guardianship authority ensures the protection of the property rights and interests of children. The regulation of property relations involving minors and their legal representatives is subject to inter-sectoral and inter-subject interaction, which must be taken into account when implementing the rights of minors and protecting them.
GAYA KEPEMIMPINAN, KEPUASAN KERJA, DAN INTENSI KARYAWAN DI PERUSAHAAN ASURANSI INDONESIA
Authors:   School of Business and Economics Universitas Prasetiya Mulya JL. RA. Kartini (TB Simatupang), Cilandak Barat Jakarta Selatan, Jakarta 12430 Indonesia, Anggraita Bryan , Dalila Dalila ,   School of Business and Economics Universitas Prasetiya Mulya JL. RA. Kartini (TB Simatupang), Cilandak Barat Jakarta Selatan, Jakarta 12430 Indonesia, Rynaldo Rynaldo ,   School of Business and Economics Universitas Prasetiya Mulya JL. RA. Kartini (TB Simatupang), Cilandak Barat Jakarta Selatan, Jakarta 12430 Indonesia, Malahayati Sri ,   School of Business and Economics Universitas Prasetiya Mulya JL. RA. Kartini (TB Simatupang), Cilandak Barat Jakarta Selatan, Jakarta 12430 Indonesia
Published: July 2021

Banyak faktor yang menyebabkan karyawan ingin bekerja lebih lama atau pindah dalam sebuah perusahaan. Penilitan ini fokus kepada faktor gaya kepemipinan transformational ataupun transactional, kepuasan kerja, dalam kaitan nya intensi karyawan untuk menginggalkan organisasi di sebuah perusahaan asuransi di Indonesia. Hasil penelitian menunjukkan bahwa kepemimpinan transformasional berpengaruh positif kepada kepuasan kerja dan sebaliknya dengan kepemimpinan transactional. Kepuasan kerja menunjukkan hubungan yang negatif dalam kaitan intensi karyawan untuk menginggalkan organisasi. Penting untuk perusahaan asuransi yang sedang berfokus dengan inisiatif transformasi bisnis untuk memastikan aspek kepemimpinan agar dapat mendorong process transformasi, mengidentifikasikan strategi dalam pencapaian visi dan misi.
Pengaruh Penggunaan Media Sosial Terhadap Ekuitas Merek Agen Perjalanan Daring
Authors:   School of Business and Economics Universitas Prasetiya Mulya JL. RA. Kartini (TB Simatupang), Cilandak Barat Jakarta Selatan, Jakarta 12430 Indonesia., Candra Adriantono , Farghani Haranna ,   School of Business and Economics Universitas Prasetiya Mulya JL. RA. Kartini (TB Simatupang), Cilandak Barat Jakarta Selatan, Jakarta 12430 Indonesia., Haidar Romy ,   School of Business and Economics Universitas Prasetiya Mulya JL. RA. Kartini (TB Simatupang), Cilandak Barat Jakarta Selatan, Jakarta 12430 Indonesia., Farisan Vito ,   School of Business and Economics Universitas Prasetiya Mulya JL. RA. Kartini (TB Simatupang), Cilandak Barat Jakarta Selatan, Jakarta 12430 Indonesia.
Published: July 2021

Penulisan ini dibuat untuk melihat respon konsumen terhadap ekuitas merek agen perjalanan daring serta pengaruh ekuitas merek secara keseluruhan kepada konsumen melalui media sosial. Kuesioner diberikan kepada setiap pengguna sebagai responden. Dari 340 responden, 329 responden diantaranya menyatakan bahwa pernah melihat agen perjalanan daring di media sosial. Hipotesa yang ada diuji menggunakan analisis regresi. Penulisan menunjukkan bahwa setiap variabel yang ada berpengaruh terhadap ekuitas merek. Dampak positif yang muncul ditunjukkan melalui hasil setiap variabel. Kesadaran merek sebagai variabel yang berpengaruh besar, dapat mendorong ekuitas merek secara komprehensif. Penulisan ini memperlihatkan bahwa ekuitas merek berperan penting. Merek merupakan identitas yang melambangkan sebuah produk. Kemudian, merek juga berfungsi sebagai pengendali pasar.
Biostratigraphy of Upper Jurassic of the Valy clay pit (Samarskaya Luka) by ammonites, ostracods and dinocysts
Authors:   Geological Institute of RAS, Rogov Mikhail A. , Savelieva Julia N. ,   AO ‘Geologorazvedka’, Shurekova Olga V. ,   AO ‘Geologorazvedka’
Published: July 2021

The results of integrate biostratigraphic study of Upper Jurassic deposits of the clay pit near the village of Valy (Syzran district, Samara region) are presented. For the first time a bed-by-bed description was made and the subdivision of the section into zones, subzones and biohorizons by ammonites was established. Bauhini and Kitchini zones (Bayi subzone) are established in the Lower Kimeridgian, while Upper Kimmeridgian is represented by Autissiodorensis zone only. In the Lower Volgian Sokolovi and Pseudoscythica zones were recognized, while the Middle Volgian is represented by the Panderi zone. The age of the regionally developed unconformity at the base of the Trazovo Formation has been clarified. As in the sections located to the south from studied section, this unconformity is located in the base of the Autissiodorensis zone, overlying different Oxfordian and lower Kimmeridgian. For the first time for Kimmeridgian of Central Russia in the marlstone band of the Kitchini zone (bayi biohorizon) solitary corals conditionally attributed to the genus Trochocyathus were found. Along with corals other warm-water taxa (belemnites Hibolithes, rare ammonites Taramelliceras) were found in the same bed, suggesting deposition of this bed during the short-time warming event. 6 biostratigraphic units (zone and beds with fauna) were recognized by ostracods, along with 2 dinocyst-based units (assemblage and zone) which are compared with the stratigraphic subdivisions by these groups, previously proposed for the Kimeridgian and Volgian stages of the Russian Platform. The paleo-ecological analysis has allowed to assume, that sediments have accumulated in the conditions of warm shallow eutrophic basin with depth to 50 m, with gradual increase of eutrophy through time. At some levels, short-term episodes of severe shallowing or freshening are recorded by ostracods.
The change in carbonate state and other properties in chronosequences of abandoned soils in different parent rocks in the reserve «Galich'ia Gora» in the Lipetsk oblast
Authors:   St. Petersburg State University, Bulysheva Anna M. , Khokhlova Olga S. ,   Institute of Physicochemical and Biological Problems of Soil Science, Bakunovich Nikita O. ,   Institute of Physicochemical and Biological Problems of Soil Science, Rusakov Alexey V. ,   St. Petersburg State University, Myakshina Tatyana N. ,   Institute of Physicochemical and Biological Problems of Soil Science
Published: July 2021

The article considers the change in the properties of Haplic Chernozems (Aric) on loesslike loams and Сalcaric Phaeozems (Aric) on Paleogene, Neogene red-colored sands with limestone eluvium of the Lipetsk region when they are transferred from cropland to fallow. The main attention is focused on the change in the carbonate status of soils. According to the results of the study, it was found that the transformation of both types of soils formed on different rocks obeys a single trend. Carbonates in Chernozems during their stay in fallow are washed down the profile; stable forms of carbonate pedofeatures gradually disappear. The content and stocks of carbonate carbon in the 0-200 cm layer in Haplic Chernozems (Aric) decrease by 27.5 t/ha by 25 years of fallow state. In Сalcaric Phaeozems (Aric), changes in the carbonate status are less pronounced; nevertheless, it was found that in the arable soil on the fragments of limestone, secondary carbonate films in the form of acicular calcite are formed on top of clay films, which was not observed in the abandoned soils. When the soil is in the fallow, the physical and mechanical properties of the soil improve: the structure of the arable horizons is improved, density decreases. The organic carbon content is reduced. This is an atypical result of postagrogenic transformation of Haplic Chernozems (Aric). In the fallow soils of other regions of steppe and forest-steppe, we observed the process of accumulation of organic carbon. The decrease in soil organic carbon while in the fallow is associated with the use of soil-saving technologies for agricultural use. The radiocarbon age of humus in subsurface horizons increases when soil is in the fallow. The radiocarbon age of carbonates in soils varies depending on the amount of lithogenic calcite inclusion.
Mineralogical features of gold of the Permian conglomerates of the Sololiy uplift of the Olenek high (Northeastern Siberian platform)
Authors:   Diamond and Precious Metal Geology Institute, Siberian Branch, Russian Academy of Sciences, Gerasimov Boris B. , Zhelonkin Roman Yu. ,   “Almazy Anabara” JSC, Mukhamedyarov Makhmutyan G. ,   “Almazy Anabara” JSC
Published: July 2021

Typomorphic features of placer gold of conglomerates of the Ortokinskaya formation of the Early Permian age (P1or) of the Sololiy Uplift of the Olenek High and modern channel alluvium of the Ortoku Eekit river, which drains these deposits, are studied. It is found that extremely heterogeneous composition and complex inner structure are typical features of the vast majority of gold of the Permian conglomerates. There are several stages of different fineness (from 251‰ to 999‰) within a single gold particle, as a result, gold has a mosaic-block inner structure. It is proposed that such heterogeneity is formed due to epigenetic transformations of primary medium-grade gold in an intermediate reservoir of the Permian age, and also under influence of superposed hydrothermal mineralization with low-grade gold, related to the processes of the Mesozoic tectonomagmatic activation. The latter is indicated by the discovery of impregnated gold-sulfide mineralization in the Permian conglomerates. Ore mineralization is represented by gold, silver, pyrite, sphalerite, chalcopyrite, galena, argentite, native tin, and barite. Association mineralization to thin tectonic zones of conglomerate fragmentation, suggests that superposed gold-sulfide hydrothermal mineralization of impregnated type was formed as a result of manifestations of the Mesozoic tectonomagmatic activation, when gold-bearing hydrothermal solutions migrated in faults. It is determined that auriferous conglomerates of the Ortokinskaya formation of the Permian age were major sources of placer gold of modern alluvium in the studied part of the Ortoku Eekit.
New data concerning the age and composition of intrusion complexes of the northern part of Balygychan-Sugoi rift depression (North-Eastern Russia)
Authors:   A. P. Karpinsky Russian Geological Research Institute, Petrova Marina N. , Petrov Semen Iu. ,   A. P. Karpinsky Russian Geological Research Institute, Kurapov Mihail Iu. ,   A. P. Karpinsky Russian Geological Research Institute,   St. Petersburg State University
Published: July 2021

The Balagychan-Sugoi (Omsukchan) riftogeneous depression is described by different authors both as a part of Okhotsk-Chukotka volcanic belt (OCVB) and as a separate structure. The unique Dukat gold and silver deposit and a lot of others ore deposits including rare-metal, such as Arylah, Lunnoe, Askold, Mechta, Tidid, Krasin, are associated with this structure. All mentioned objects are located in the south part of the depression and from this point of view are connected with OCVB structure. Evolution of the Balygychan-Sugoi depression is closely related to the stages of magmatic evolution of the region. In the article, these stages are characterized based on the data form intrusion bodies located in the northern part (Naygain depression). This part is the most outlying from the OCVB and less investigated. For the first time, the U-Pb zircon and baddeleyite dating and the description of petrographic and geochemical composition have been carried out for Mandychan gabbro-diorite and Nayahan gabbro leucogranite intrusion complexes from the northern part of the depression and for Omsukchan leucogranite complex. The Late Jurassic – Early Cretaceous intrusions of the Mandychansk complex dated as 143-139 Ma mark the beginning of the rift depression formation. Intrusion of granitoids of the Nayahan and Omsukchan complexes dated as 84-85 Ma and 81-82 Ma correspondently is related with new stage of magmatic activity, synchronous to OCVB formation. The petrographic and geochemical compositions of these granitoids indicate their belonging to the I-type granites, which are typical for extension environments, whereas leucogranites of the Omsukchan complex have some features corresponding to the A-type granites.
Seismotectonics of Armenia: main problems
Authors:   Shirak State University after M. Nalbandian, Sargsyan Rudolf S. , Ghazaryan Karlen S. ,   Institute of Geophysics and Engineering Seismology after A. Nazarov of NAS RA, Burmin Valeriy Yu. ,   Schmidt Institute of Physics of the Earth of the Russian Academy of Sciences
Published: July 2021

The article describes the main problems in the existing researches on the seismotectonics of the territory of Armenia. A review was conducted on certain issues related to the accuracy of the initial seismological data, the problem of identifying possible focal zones of strong earthquakes, and the probabilistic assessment of the seismic hazard of the territory of Armenia. As the results of numerous studies show, the initial seismological data from catalogs and bulletins are characterized by their heterogeneity. Different observation systems and different methods of seismological data processing have led to the fact that when visualizing the spatial distribution of earthquake epicenters on the territory of Armenia, during the instrumental period of observations, an artificially lattice network of epicenters is obtained, which does not agree in any way with the fault tectonics of the territory. During the stud of distribution of earthquake hypocenters by depth, the discrete nature of their distribution was revealed. There is also a number of disadvantages in the area of allocation of focal zones of strong earthquakes. The main part of the conducted research was mainly based on data on previously recorded strong seismic events, as well as on data on historical earthquakes, as a result, for the most part of the studied territory, in fact, no research was conducted. In addition, there are relevant questions about the tectonic basis used in these studies. The last group of problems concerns the probabilistic assessment of the seismic hazard of the territory of Armenia. It is shown that in the existing works, there are quite a lot of unsubstantiated assumptions.Based on the analysis, it is concluded that in the field of seismotectonic studies of the territory of Armenia, there are a number of urgent tasks that require priority solutions.
A problem of multi-drug resistant infectious in pediatric lymphoma treatment
Authors: Valiev T. T. , Matinyan N. V. , Epifanova N. Yu. , Babelyan S. S. , Zakharova E. V. , Belysheva T. S. , Gromova E. G. , Kirgizov K. I. , Polyakov V. G. , Varfolomeeva S. R.
Published: July 2021

The basis of modern high-effective therapeutic programs for pediatric lymphomas is an intensive, risk-adopted therapy, which complicated with myelosuppression. In myelotoxic agranulocytosis condition infectious complications are often and its treatment results depend on duration and level of agranulocytosis, and sensitivity of microorganism to antimicrobial agents. Multi-drug resistant strains of Pseudomonas aeruginosa, Acinetobacter baumannii and etc. are a serious problem in supportive care of postchemotherapy complications, when even multidisciplinary approach with pediatric oncologists/hematologists, microbiologists, clinical pharmacists, surgeons, specialists in extracorporeal blood purification modalities and intensive care are ineffective.
Results of surgical treatment of localized and locally advanced adrenocortical cancer in children
Authors: Temniy A. S. , Kazantsev A. P. , Kerimov P. A. , Kalinchenko N. Yu. , Rubanskaya M. V. , Sardalova S. A. , Varfolomeeva S. R.
Published: July 2021

Introduction. Adrenal cortical carcinoma (ACC) is a rare cancer but is the most common primary cancer in the adrenal gland. Despite the low incidence of ACC the mortality rate ranges from 0.04 to 0.2 %, in the overall structure of cancer mortality. Treatment of ACC is mainly surgical and radical surgical excision is the treatment of choice for local disease stages.

Aim of the study — to present our results of surgical treatment of localized and locally advanced ACC in children and to determine the risk factors of relapse.

Materials and methods. Twenty-eight patients (median age of 47.8 (06—216) mo.) with localized and locally advanced ACC underwent a retrospectively analysis. Stage I, II, and III revealed in 12 (45 %), 7 (25 %), and 9 (30 %), respectively. In 19 (68 %) cases the secretion of one or more hormone observed. Macroscopically and microscopically complete resection were performed in 26 (93 %) and 23 (82 %) patients, respectively. The median tumor volume was 183 (3.6—1608) cm3 and the median tumor weight was 207.9 (48—710) g.

Results. Five-year overall (OS) and relapse-free (RFS) survival were 71 % and 69 %, respectively. OS and RFS according to stage I, II, and III were 100 % vs. 71 % vs. 17 % and 100 % vs. 71 % vs. 14 % respectively. The radical surgical resection and the level of Ki-67 expression influenced significantly the rates of OS and RFS (p < 0.001).

Conclusion. The main factor affecting the survival rate of ACC in children with stages I—III is the radical surgical resection. It should be taken into account when planning postoperative therapy. Some of biological characteristics of the tumor could also significantly affect the results of treatment.
Extended surgical interventions in children with retinoblastoma invasion into the optic nerve
Authors: Ushakova T. L. , Tuzova E. A. , Shutova A. D. , Gorovtsova O. V. , Gasparyan T. G. , Bekyashev A. Kh. , Polyakov V. G.
Published: July 2021

Introduction. Standard eye enucleation (EE) may not always guarantee a sufficient length of resection of the optic nerve (ON) so that the tumor cells do not spread along the optic nerve at the intersection line. Surgical access and the scope of surgical intervention are determined by the spread and localization of the tumor, as well as the qualification of the operating team.

Purpose— to evaluate the role of extended surgical interventions in the spread of extraocular tumors on the ON.

Materials and methods. The study included 9 patients with retinoblastoma (RB) and macroinvasion of the ON during primary magnetic resonance imaging (MRI) and/or micromorphological invasion of the ON resection line after EE. 4 of the 9 patients were treated with primary/secondary EE, induction chemotherapy (CT) and high-dose CT (HDCT), radiation therapy (RT). 5 out of 9 patients underwent secondary extended surgical interventions: exenteration of the orbit (n = 1), osteoplastic lateral orbitotomy with precanal resection of the ON (n = 2) in combination with EE in one case, subfrontal craniotomy (n = 1) and orbitozygomatic craniotomy (n = 1) with prechiasmal resection of the ON and EE with adjuvant RT (excluding the latter case) and CT, without HDCT.

Results. It should be noted that the overall survival (OS) of 5 patients with complete microscopic resection (R0) after extended secondary operations was 75 ± 0.217 % with an average follow-up period of 77.25 ± 18.8 months, while in 4 patients with R1 (n = 4) without secondary extended operations with HDCT reached only 50 ± 0.25 % with an average follow-up period of 57 ± 24.8 months.

Conclusion. MRI is mandatory for the primary diagnosis of RB, especially when there is a risk of the tumor spreading through the ON. Secondary surgery with R0-resection has a positive effect on survival. The need for adjuvant RT and CT after surgery should be discussed.
The Impact of COVID-19 on General and Dental Health
Authors: Jaiswal Priyanka , Banode Pankaj , Agrawal Diksha , Bajaj Pavan , Masurkar Deepika , Gadbail Amol
Published: July 2021

COVID-19 (Coronavirus disease 2019) is a contagious infection caused by novel coronavirus SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2). This novel virus was publicly announced as an infectious pathogen by the “Chinese Centre for Disease Control and Prevention” on 8 January 2020. The World Health Organization named COVID-19 a pandemic crisis all over the world on March 11, 2020. Aged people and medically compromised people like patients with diabetes, cardiovascular disease, chronic respiratory disease, and cancer are the vulnerable populations for developing an illness. A guideline has been postulated and described in the form of a journey map to avoid exposure of dental health care professionals to COVID-19. This review provides a comprehensive outlook for the current pandemic situation, its origin, spread, and preventive measures to be utilized in general and in dental practice.
Inventario florístico de plantas vasculares en fragmentos de bosque seco tropical en el departamento Magdalena, Colombia
Authors: Herazo Vitola Fran , Carrascal Prasca Dairo Enrique , Herrera Castillo Maziel , Valencia-Cuéllar Dayana Sofía
Published: July 2021

Antecedentes y Objetivos: El bosque seco tropical es uno de los ecosistemas más amenazados en el mundo, principalmente por afectaciones antrópicas y ambientales. Se presenta el inventario de la flora vascular en fragmentos de bosque seco durante un periodo de baja precipitación en la subregión Norte, Centro y Sur del departamento Magdalena, Colombia.Métodos: Se realizó un inventario florístico en seis puntos de muestreo con cinco transectos (0.1 ha) en cada uno, distribuidos de forma aleatoria, sumando un total de 0.6 ha. Se censaron todas las plantas con diámetro a la altura del pecho (DAP) ≥1 cm y altura mínima de 1.5 m y se registró el hábito de crecimiento. El trabajo de campo fue de noviembre 2019 a febrero de 2020. Las especies se identificaron utilizando claves taxonómicas y consultando colecciones en línea, los nombres se corroboraron en IPNI y el Catálogo de plantas y líquenes de Colombia. Se comprobó la veracidad del muestreo con curvas de acumulación y se efectuó una correlación entre los valores de riqueza y precipitación. Resultados clave: Se registraron 191 especies, distribuidas en 52 familias, siendo las más representadas Fabaceae (47) y Bignoniaceae (16). La especie más frecuente fue Handroanthus chrysanthus y el hábito de crecimiento fue el de árbol (65%). El indicador no paramétrico Bootstrap fue el que mejor se ajustó al número de especies esperadas, arrojando un porcentaje de completitud de 87.26%. Los datos de precipitación no se correlacionaron significativamente (R=0.53 y P=0.27) con los totales de riqueza inventariados.Conclusiones: Este inventario permitirá generar nuevos aportes científicos de la flora en el bosque seco tropical del departamento Magdalena. La dominancia de especies como Handroanthus chrysanthus y Bursera simaruba puede deberse a las adaptaciones morfológicas expresadas en mecanismos fisiológicos para tolerar periodos sin precipitaciones.
Ultrasonographic detection of meningoencephalitis in a dog
Authors: Rossi-Feliciano Marcus Antônio , Kretzer-Carneiro Rafael , Kniphoff da Cruz Igor Cezar , Moraes-Pereira Tainara , Pozzobon Ricardo , Ripplinger Angel , Mazzanti Alexandre , Lie Yamauchi Camila , Jaques Ramos Denise , Ribeiro Gusman Laura Magalhães
Published: July 2021

The aim of this report is to disseminate ultrasound findings of meningoencephalitis in a dog, diagnosed by analysis of cerebrospinal fluid collected by guided-ultrasound puncture. The patient presented walking in circles, absence of bilateral threat reflex, decreased left eyelid reflex, divergent strabismus of the right eye, negative nasal sensation on the right side, and an increase in volume of skullcap with the presence of open fontanelle. The clinical suspicion was hydrocephalus and/or inflammatory/infectious disease. The distemper rapid test was negative. The hematological profile showed an increase in alanine aminotransferase enzyme. Ultrasound examination was performed with patient in sternal decubitus, using a linear transducer (9.0 MHz). Images were obtained in longitudinal and transverse sections through the temporal windows and bregmatic fontanelle. The presence of a marked anechogenic content with moderate amount of floating hyperechogenic spots was observed, with retraction and increased echogenicity of the brain. Cerebrospinal fluid was collected using the bregmatic fontanelle for ultrasound-guided puncture, under general anesthesia. Meningoencephalitis was indicated by mononucleated cells and red blood cells founded in cerebrospinal fluid analysis. However, the patient not return to start treatment and investigate the cause of the meningoencephalitis.
Effects of Patient Portal Use on Patient Satisfaction: Survey and Partial Least Squares Analysis
Authors: Kinney Aaron P , Sankaranarayanan Balaji
Published: July 2021

Background

With digital delivery of health care services gaining prominence, patient portals have become a mainstay of many health care organizations. Despite the importance of patient portals, inconclusive data exist regarding the effect of patient portal use on patient satisfaction.

Objective

The aim of this study is to understand the relationship between the postadoptive use of patient portals and patient satisfaction outcomes.

Methods

Postadoptive use of patient portals has a positive relationship with the 3 dimensions of patient satisfaction, mediated by gratification, health self-awareness, and health perceptions. A total of 504 valid patient portal user responses were collected, and partial least squares analysis was performed to analyze the data.

Results

Patient satisfaction was captured using three dimensions: care team interaction, atmosphere, and instruction effectiveness. The results show that postadoptive use of patient portals has a positive influence on all 3 dimensions of patient satisfaction through the mediating variables of gratification, health self-awareness, and health perceptions. Specifically, postadoptive use had significant positive influence on gratification, health self-awareness, and health perceptions. Each of the 3 patient perceptions had significant positive influence on all 3 dimensions of patient satisfaction: care team interaction, atmosphere, and instruction effectiveness. Specifically, our model explained 31.8% of the care team interaction, 40.6% of the atmosphere, and 39.1% of the instruction effectiveness.

Conclusions

Our model shows that patient portal use can influence patient satisfaction through the mediating effects of gratification, health self-awareness, and health perception. Patient satisfaction is an important outcome for health care organizations. Therefore, by promoting effective patient portal use and fostering patient perceptions, health care organizations can improve patient satisfaction.
The Effectiveness of a Web-Based Self-Help Program to Reduce Alcohol Use Among Adults With Drinking Patterns Considered Harmful, Hazardous, or Suggestive of Dependence in Four Low- and Middle-Income Countries: Randomized Controlled Trial
Authors: Schaub Michael P , Tiburcio Marcela , Martínez-Vélez Nora , Ambekar Atul , Bhad Roshan , Wenger Andreas , Baumgartner Christian , Padruchny Dzianis , Osipchik Sergey , Poznyak Vladimir , Rekve Dag , Landi Moraes Fabricio , Monezi Andrade André Luiz , Oliveira Souza-Formigoni Maria Lucia ,   WHO E-Health Project On Alcohol And Health Investigators Group
Published: July 2021

Background

Given the scarcity of alcohol prevention and use disorder treatments in many low- and middle-income countries (LMICs), the World Health Organization has launched an eHealth portal that includes the web-based self-help program “Alcohol e-Health.”

Objective

We aimed to test the effectiveness of the Alcohol e-Health program in a randomized controlled trial.

Methods

This was a two-arm, individually randomized, and controlled trial across four LMICs comparing the self-help program and a psychoeducation and internet access as usual waiting list. Participants were broadly recruited from community samples in Belarus, Brazil, India, and Mexico from January 2016 through January 2019. The primary outcome measure was change in the Alcohol Use Disorders Identification Test (AUDIT) score with a time frame of 6 months between baseline and follow-up. Secondary outcomes included self-reported numbers of standard drinks over the previous week and cessation of harmful or hazardous drinking (AUDIT score <8).

Results

For this study, we recruited 1400 predominantly male (n=982, 70.1%) at least harmful or hazardous alcohol drinkers. The mean age was 37.6 years (SD 10.5). The participants were recruited from Brazil (n=587), Mexico (n=509), India (n=212), and Belarus (n=92). Overall, complete case analysis identified higher AUDIT changes in the intervention group (B=−4.18, 95% CI −5.42 to −2.93, P<.001, d=0.56) that were mirrored by changes in weekly standard drinks (B=−9.34, 95% CI −15.90 to −2.77, P=.005, d=0.28) and cessation rates for harmful or hazardous drinking (χ21=14.56, N=561, P<.001). The supplementary intention-to-treat analyses largely confirmed these initial results.

Conclusions

The expansion of the Alcohol e-Health program to other LMICs with underdeveloped alcohol prevention and treatment systems for alcohol use disorders should be considered after successful replication of the present results.

Trial Registration

ISRCTN ISRCTN14037475; https://www.isrctn.com/ISRCTN14037475

International Registered Report Identifier (IRRID)

RR2-10.1111/add.14034
Digital Medical Device Companion (MyIUS) for New Users of Intrauterine Systems: App Development Study
Authors: Karakoyun Toeresin , Podhaisky Hans-Peter , Frenz Ann-Kathrin , Schuhmann-Giampieri Gabriele , Ushikusa Thais , Schröder Daniel , Zvolanek Michal , Lopes Da Silva Filho Agnaldo
Published: July 2021

Background

Women choosing a levonorgestrel-releasing intrauterine system may experience changes in their menstrual bleeding pattern during the first months following placement.

Objective

Although health care professionals (HCPs) can provide counseling, no method of providing individualized information on the expected bleeding pattern or continued support is currently available for women experiencing postplacement bleeding changes. We aim to develop a mobile phone–based medical app (MyIUS) to meet this need and provide a digital companion to women after the placement of the intrauterine system.

Methods

The MyIUS app is classified as a medical device and uses an artificial intelligence–based bleeding pattern prediction algorithm to estimate a woman’s future bleeding pattern in terms of intensity and regularity. We developed the app with the help of a multidisciplinary team by using a robust and high-quality design process in the context of a constantly evolving regulatory landscape. The development framework consisted of a phased approach including ideation, feasibility and concept finalization, product development, and product deployment or localization stages.

Results

The MyIUS app was considered useful by HCPs and easy to use by women who were consulted during the development process. Following the launch of the sustainable app in selected pilot countries, performance metrics will be gathered to facilitate further technical and feature updates and enhancements. A real-world performance study will also be conducted to allow us to upgrade the app in accordance with the new European Commission Medical Device legislation and to validate the bleeding pattern prediction algorithm in a real-world setting.

Conclusions

By providing a meaningful estimation of bleeding patterns and allowing an individualized approach to counseling and discussions about contraceptive method choice, the MyIUS app offers a useful tool that may benefit both women and HCPs. Further work is needed to validate the performance of the prediction algorithm and MyIUS app in a real-world setting.
Impact of the COVID-19 Pandemic on the Mental Health of College Students in India: Cross-sectional Web-Based Study
Authors: Chaudhary Amar Prashad , Sonar Narayan Sah , TR Jamuna , Banerjee Moumita , Yadav Shailesh
Published: July 2021

Background

The COVID-19 pandemic has created a mental health crisis among college students in India due to lockdown restrictions, overwhelming numbers of COVID-19 cases, financial difficulty, etc. This mental health crisis has led to high degrees of fear, anxiety, and depression among college students.

Objective

The aim of this study is to investigate symptoms of fear, depression, and anxiety due to the COVID-19 pandemic among college students in India.

Methods

This cross-sectional web-based study was conducted using a Google Forms questionnaire. The Google Form included a sociodemographic questionnaire and psychometric scales evaluating the psychological and behavioral impacts of the COVID-19 pandemic. Thus, both qualitative and quantitative analyses were performed in the study.

Results

A total of 324 college students participated in this study, of whom 180 (55.6%) were male and 144 (44.4%) were female. After assessment of the psychometric scales, it was found that of the 324 students, 223 (68.8%) had high fear of COVID-19, 93 (28.7%) had moderate to severe depression, and 167 (51.5%) had mild to severe anxiety. Among the identified risk factors, having a family member who was infected with COVID-19 was significantly associated with anxiety and depression, with P values of .02 and .001, respectively. In addition, the correlations of the Fear of COVID-19 Scale with the Generalized Anxiety Disorder-7 scale and the Patient Health Questionnaire-9 were found to be 0.492 and 0.474, respectively.

Conclusions

This research concludes that there is a very high fear of COVID-19 among students, along with anxiety and depression symptoms. This study also concludes that the Fear of COVID-19 Scale has a moderate positive correlation with the anxiety and depression scales, respectively.
Internet Searches for Terms Related to Child Maltreatment During COVID-19: Infodemiology Approach (Preprint)
Authors: Riem Madelon M E , De Carli Pietro , Guo Jing , Bakermans-Kranenburg Marian J , van IJzendoorn Marinus H , Lodder Paul
Published: July 2021

UNSTRUCTURED

We examined internet searches indicative of abusive parental behaviors before and after the World Health Organization’s declaration of COVID-19 as a pandemic (March 11, 2020) and subsequent lockdown measures in many countries worldwide. Using Google Trends, we inferred search trends between December 28, 2018, and December 27, 2020, for queries consisting of “mother,” “father,” or “parents” combined with each of the 11 maltreatment-related verbs used in the Conflict Tactics Scales, Parent-Child version. Raw search counts from the Google Trends data were estimated using Comscore. Of all 33 search terms, 28 terms showed increases in counts after the lockdowns began. These findings indicate a strong increase in internet searches relating to occurrence, causes, or consequences of emotional and physical maltreatment since the lockdowns began and call for the use of maltreatment-related queries to direct parents or children to online information and support.
On the Regulatory Capabilities of Thyroid Mast Cells in Thiamazole Model of Hypothyroidism and Infrared Laser Exposure
Authors:   Multidisciplinary Center of Laser Medicine, Smelova Irina V. , Golovneva Elena S. ,   Multidisciplinary Center of Laser Medicine, Kravchenko Tatyana G. ,   Multidisciplinary Center of Laser Medicine, Petuсhova Victorya I. ,   Multidisciplinary Center of Laser Medicine
Published: July 2021

The regulatory effect of mast cells on the state of thyroid gland in hypothyroidism and laser therapy remains unclear. Aim: to study the secretory processes of mast cells in relationship with the indicators of functional activity of thyroid gland. Materials and methods. Experimental groups: (55 rats) 1) intact rats, 2) hypothyroidism (thiamazole 25mg/kg) 3) hypothyroidism and 0.5W laser exposure, 4) hypothyroidism and 2.0W laser exposure. Histological samples of the thyroid gland were removed on the 1, 7, and 30 days. Histological sections were stained with toluidine blue. Morphometric data analysis included descriptive statistics and non-parametric tests (Mann Whitney, Spearman correlation coefficient). Results. The increase in the granular saturation of mast cells and the average histochemical coefficient was observed in the hypothyroidism group, the degranulation index increased by day 30. After 0.5 W laser exposure, there was a decrease in the granular content in mast cells and an increase in the degranulation index; the granular saturation increased by day 30. After 2.0 W laser exposure, the content of granules in mast cells decreased on day 1, and on days 7 and 30 it was higher than in the hypothyroidism group; the degranulation index decreased by day 30. The correlation was revealed between the indicators of granule accumulation in a mast cell, the index of mast cell degranulation, the thyroid epithelium height, and relative vascular area. Conclusions. The synthesis processes prevailed over secretion for mastocytes in thiamazole hypothyroidism. 0.5 W laser exposure was more effective for stimulation of the secretory processes in mast cells compared to 2.0 W exposure. The secretory activity of mast cells was associated with the functional activity of thyroid gland, which confirms their regulatory role in tissue repair after thiamazole induced hypothyroidism modeling.
Age-Related Features of the Distribution of the Frequency of Occurrence of Luminal A Molecular-Biological Subtype of Breast Cancer
Authors:   Ural State Medical University, Novikova Evgeniya A. , Krokhalev Vadim Ya. ,   Ural State Medical University, Kostromina Olga V. ,   Ural State Medical University, Demidov Sergei M. ,   Institute of Medical Cell Technologies, Sazonov Sergey V. ,   Ural State Medical University
Published: July 2021

Aim. In this article, we analyzed the age-related features of molecular- biological subtypes in 499 patients with invasive breast cancer. Materials and research methods. All cases were divided into 5 molecular- biological subtypes based on immunohistochemical studies of hormone receptors, Her2, Ki-67. Luminal (A and B) with the expression of estrogen and/or progesterone receptors (ER+/PR+), accounting for about 50-80% of all breast cancer cases and potentially sensitive, especially luminal A, to hormone therapy. Research results. The analysis showed that in our study the proportion of the Luminal A subtype was lower than the generally accepted values of 37.4% of all studied breast cancer cases. In the group of women under 40 years of age (with preserved menstrual-ovarian function), cases of Luminal A subtype were significantly less common (9.03%) compared to the groups of 41-50 years (p<0.006), 51-60 years (p<0.001), and over 60 (p<0.001). There was also a decrease in the proportion of Luminal A subtype among patients older than 60 years (p=0.0064). No significant differences were found between the groups 41-50 and over 60 years of age (p=0.1868).
Sex Differences in Cerebral Energy Exchange Among Residents of the Arctic Zone of the Russian Federation
Authors:   Northern (Arctic) Federal University named after M. V. Lomonosov, Kottsova Olga N. , Anikina Natalia Yu. ,   Northern State Medical University, Gribanov Anatoly V. ,   Northern (Arctic) Federal University named after M. V. Lomonosov
Published: July 2021

This article presents the sexual characteristics of cerebral energy metabolism in young residents of the Arctic zone according to the distribution of the level of direct constant potential (DC-potential level) of the brain. The study involved 60 people (27 men and 33 women) aged 30-34 years, born and living in the Arctic territory. Assessment of cerebral energy exchange was carried out using a 5-channel hardware-software diagnostic complex «NeuroKM». The distribution of the DC-potential level was analyzed by mapping monopolar values and calculating their gradients. For statistical data processing, the SPSS Statistics26 software package was used. The obtained DC-potentials level results were compared with the average statistical standard values. As a result of the study, gender differences in cerebral energy exchange were revealed in working-age residents born and living in the Arctic zone, depending on gender. In the group of men, there is a higher intensity of cerebral energy exchange in the whole cerebral cortex, the absence of pronounced hemispheric dominance, activation of the central and frontal cortex. In women, there is no predominance of energy exchange in any one area, there are low total indicators, activation of the central and occipital regions of the cortex; connection of the central cortex with the temporal, right-hemisphere dominance of cerebral energy exchange processes. Conclusion. Men are characterized by centralization and tension of regulatory systems, which can be an unfavorable factor in ensuring long-term adaptation to the climatic conditions of the Arctic. Women have a more optimal level of cerebral energy exchange.
Community-acquired pneumonia in inpatients during the epidemic of the new coronivarus infection of COVID-19
Authors: Trykhlib V.I. , Bieliaieva K.P. , Popenko N.V. , Tsiurak N.R. , Lysenko T.I. , Yeroshenko A.O. , Martynchyk О.S. , Chernyak V.A. , Shevelova T.I. , Popova S.S. , Samoilova S.M. , Chaika S.M. , Holubenko O.S. , Moroz А.V.
Published: July 2021

The article reviews the literature on community-acquired pneumonia. Own results of study on the features of clinical, laboratory, and instrumental manifestations of community-acquired pneumonia during epidemic of the new coronavirus infection of COVID-19 are given.
Tratamiento de la enfermedad periodontal con células troncales de origen pulpar, en un adulto mayor. Caso clínico
Authors: Fabila-Plata Miriam Susana , Hernández Palacios Rosa Diana
Published: July 2021

Introducción. La enfermedad periodontal (EP) es un padecimiento de tipo inflamatorio crónico y con frecuencia causa pérdida dental en los adultos mayores. Su tratamiento se orienta a la regeneración de los tejidos periodontales a través de la eliminación de los agentes infecciosos presentes en el periodonto y en la sustitución del hueso alveolar perdido. Caso clínico. Paciente femenina de 61 años de edad que acudió a consulta estomatológica por presentar movilidad dental. En la valoración bucal se observó enfermedad periodontal. Se realizaron las tres fases de la terapia periodontal con aplicación de células troncales mesenquimales (Mesenchymal Stem Cells, MSC) de origen pulpar, mostrando disminución de la profundidad al sondaje y aumento en el nivel de inserción clínica. Conclusiones. Los hallazgos sugieren que la terapia periodontal regenerativa con MSC de origen pulpar representan una opción para el tratamiento de los defectos óseos ocasionados por la EP en los adultos mayores; sin embargo, es necesario llevar a cabo ensayos clínicos controlados y aumentar el tamaño de la muestra para recomendar su aplicación en la práctica clínica.
Sarcoma de Kaposi epidémico. Una revisión narrativa
Authors: Vázquez-Aguirre Nallely Alejandra , Morales-Santaella Ana Lilia , Hernández-Monjaraz Beatriz
Published: July 2021

Introducción. El sarcoma de Kaposi (SK) es una neoplasia maligna de células endoteliales linfáticas. La principal localización es cutánea y su diagnóstico definitivo se establece mediante un estudio histopatológico. Objetivo. Presentar el estado del arte del conocimiento sobre el sarcoma de Kaposi de tipo epidémico Desarrollo. Existen cuatro tipos clínicos de SK: el clásico, el endémico o africano, el iatrogénico y el epidémico o asociado a VIH (KSHV). Este último, es la neoplasia más frecuentemente asociada al virus de inmunodeficiencia humana (VIH). También se ha asociado al herpes virus humano 8 (HHV-8) y puede ser agente causal del KSHV. Conclusiones. La detección y tratamiento oportuno del KSHV, incrementa la esperanza de vida de los pacientes con VIH. Además, el reconocimiento y las medidas de salud pública pueden reducir su propagación y ayudar a reducir la incidencia del KSHV.