bluuebunny/crossref_metadata_2025 huggingface dataset:
BRAND PERSONALITY DIMENSIONS OF SPORTSWEAR -AN EMPIRICAL ANALYSIS IN BAHRAIN
Authors: Sattar Abulbaqi Al-Azzawi Abdul
Published: January 2020

Purpose of the study: This Study helps consumers to differentiate between the products available in the same product category. Methodology: The sample design which is used is Nike sportswear; the data were collected from 300 University of Bahrain students studying in Bahrain. In order to analyze the data, factor analysis and multiple regression techniques were applied. Main Findings: The results indicated that four brand personality dimensions were extracted for the Nike sportswear brand named as Competence, Sincerity, Sophistication, and Excitement. The factors forming the brand personality of Nike were Logo, User Imagery and Advertisement Style. Applications of this study: This study will enable the marketing practitioners to better understand the personality of Nike sportswear brand from the minds of consumers and better distinguish Nike brand from their competitors. Novelty/Originality of this study: This study will benefit marketing practitioners to understand sportswear brands from the minds of consumers and distinguish their brand from the competitors based on brand personality dimensions, Aaker’s brand personality scale.
A Comparative Study of Leptin, Oxidant/Antioxidant Status and Some Trace Elements in Women of Healthy Control and Unexplained Infertility in Basrah-Iraq
Authors: Al-Fartosy Adnan Jassim Mohammed , Awad Nadhum Abdulnabi , Mahmood Rsha Abdulradha
Published: January 2020

BACKGROUND: To date, there is no study regarding women with unexplained infertility in the province of Basrah, Iraq. This study was conducted to compare the level of leptin, oxidant/antioxidant status, and some trace element levels in women of healthy control and unexplained infertility.METHODS: From total 96 women subjects, 32 subjects had primary unexplained infertility, 31 had secondary unexplained infertility, while 33 fertile women were taken as controls. The body mass index (BMI) of subjects was calculated with standard procedures. The level of fasting serum leptin, luteinizing hormone (LH), follicle stimulating hormone (FSH), prolactin (PRL), thyroid-stimulating hormone (TSH), 4-hydroxynonenal (4-HNE), lipid hydroperoxide (LOOH), glutathione (GSH), superoxide dismutase (SOD), catalase (CAT) and the total antioxidant capacity (TAC) were determined by enzyme-linked immunosorbent assay (ELISA) methods. Magnesium (Mg) and zinc (Zn) were measured by flame, copper (Cu) by flameless atomic absorption spectrometry, while Selenium (Se) in whole blood was determined using hydride generation method.RESULTS: Non-significant changes (p>0.05) were seen in the level of BMI, leptin, TSH, FSH, LH and LH/FSH ratio. Level of 4-HNE, LOOH and Cu were significantly increased (p<0.01), while level of GSH, SOD, CAT, TAC, Se, Zn and Mg were significantly decreased (p<0.01) in primary and secondary type of unexplained infertility, compared to control.CONCLUSION: Serum leptin hormone is significantly associated with BMI and physical activity in both groups. The significant difference in oxidant/antioxidants status between unexplained infertile and fertile women may suggests a possible additional role of oxidative stress mechanisms in pathophysiology of unexplained infertility.KEYWORDS: unexplained infertility, leptin, oxidative stress, antioxidants, trace elements
Program Sekolah Adiwiyata dalam Pengembangan Sosio-Emosional Anak Usia Dasar di SDN Ngupasan Yogyakarta
Authors: Majdi Muhammad
Published: January 2020

Perkembangan sosial emosional yang positif atau baik merupakan prediktor untuk kesuksesan dalam bidang akademik, kognitif, sosial dan emosional dalam kehidupan anak selanjutnya. Penelitian ini dilaksanakan di SDN Ngupasan Yogyakarta agar peneliti dapat melihat sejauh mana hasil pencapaian dari program Adiwiyata dalam pengembangan sosio emosional anak. Jenis penelitian ini adalah Field research menggunakan Pendekatan Kualitatif dan metode diskriptif. Hasil penelitian menunjukkan bahwa program sekolah Adiwiyata meliputi (1) Kebijakan berwawasan lingkungan. (2) Pelaksanaan kurikulum berbasis lingkungan. (3) Kegiatan lingkungan berbasis partisipatif. (4) Pengelolaan sarana pendukung ramah lngkungan. Kontribusi dari Implementasi Program Sekolah Ramah Lingkungan dalam pengembangan sosio emosional anak usia dasar adalah anak mampu mengontrol emosi, membantu dan senang bekerjasama serta bertanggung jawab, responsif, dapat memainkan permainan memakai aturan dan dapat menciptakannya, peduli, sensitif, lebih percaya dan mandiri, terikat pada figur orang tua.
DESIGUALDADES NO ENSINO MÉDIO: o que faz o estudante-trabalhador
Authors: Moura Dante Henrique , Lima Filho Domingos Leite
Published: January 2020

Tendo como referencial o materialismo histórico-dialético, o texto discute o ensino médio brasileiro, com foco em suas concepções e nas políticas desenvolvidas nesse âmbito, buscando-se produzir uma síntese sobre os embates que permeiam esta etapa educacional. Em seguida, por meio de pesquisa empírica, discutem-se as distintas atividades desenvolvidas por estudantes do EM das esferas estadual e federal que declararam trabalhar. Concluiu-se que há uma hierarquização no que se refere ao grau de complexidade das atividades desenvolvidas no mundo do trabalho, em função do tipo de ensino médio cursado e da esfera na qual estuda: estadual ou federal.Palavras-chave: Sujeitos do ensino médio. Mundo do trabalho. Desigualdade. Hierarquização.INEQUALITIES IN HIGH SCHOOL: what makes the student-workerAbstractTaking as reference the historical-dialectical materialism, the text discusses Brazilian high school, focusing on conceptions, policies and programs developed in this scope, seeking to produce a synthesis on the struggles that permeate this stage of basic education. From there, through empirical research, we discuss the different activities developed by state and federal students who declare to work while attending high school. It was concluded that there is a hierarchy regarding the degree of complexity of the activities developed in the world of work, according to the type of secondary education studied and whether this occurs at the state or federal levelKeywords: High school subjects. Work world. Inequality. Hierarchy.DESIGUALDADES EN LA ESCUELA SECUNDARIA: ¿qué hace el estudiante trabajador?ResumenTeniendo como referencia el materialismo histórico-dialéctico, el texto discute la escuela secundaria brasileña, enfocándose en sus concepciones y las políticas desarrolladas en esta área, buscando producir una síntesis sobre los enfrentamientos que impregnan esta etapa educativa. Luego, a través de la investigación empírica, discutimos las diferentes actividades desarrolladas por los estudiantes de la escuela seundaria de las esferas estatales y federales que declararon trabajar. Se concluyó que existe una jerarquía con respecto al grado de complejidad de las actividades desarrolladas en el mundo del trabajo, dependiendo del tipo de escuela secundaria a la que asiste y la esfera en la que estudia: estatal o federal.Palavras clave: Sujetos de la secundaria. Mundo de trabajo. Desigualdad. Jerarquización
Merhamet Yorgunluğu Kısa Ölçeği’nin Türkçe’ye Uyarlanması, Geçerlilik ve Güvenirliği
Authors: DİNÇ Sevgi , EKİNCİ Mine
Published: January 2020

Bu araştırmada Merhamet Yorgunluğu- Kısa Ölçek (MY-KÖ)’in Türkçe’ye uyarlanarak geçerlilik ve güvenirliliğinin incelenmesi amaçlanmıştır. Araştırmanın verileri bir üniversite hastanesinde çalışan 128 hemşireden elde edilmiştir. Ölçeğin faktör yapısını belirlemek için açıklayıcı ve doğrulayıcı faktör analizi, ölçüt geçerliliği için Spearman’s korelasyon katsayısı ve güvenirlilik için Cronbach α katsayısı, madde toplam korelasyonu kullanıldı. Açıklayıcı ve doğrulayıcı faktör analizi sonuçları doğrultusunda ölçeğin iki boyutlu bir yapı gösterdiği ortaya konulmuştur. Ölçeğe ait bütün maddelerin faktör yüklerinin 0.40’ın üzerinde olduğu bulunmuştur ve ölçekten hiçbir madde çıkarmadan orjinal ölçekle benzer şekilde iki alt boyutlu yapı kabul edilmiştir (x2=106.72; df=61; RMSEA=0.007; p=0.0001). MY- KÖ Cronbach α katsayısı 0.876; ikincil travma alt boyutu için 0.748 ve mesleki tükenmişlik alt boyutu için 0.852 olarak belirlenmiştir. Bu çalışma sonucunda Merhamet Yorgunluğu- Kısa Ölçeğinin merhamet yorgunluğunun değerlendirilmesinde geçerli ve güvenilir bir değerlendirme aracı olduğu saptanmıştır.
Üniversite Öğrencilerinde Çocukluk Çağı Travması ve Yeme Tutumları İlişkisi
Authors: TUNÇ Pervin
Published: January 2020

Bu çalışma çocukluk çağı travmasının ve bazı demografik özelliklerin yeme tutumları üzerindeki yordama etkisini incelemeyi amaçlamıştır. Bu kesitsel çalışmaya 612 üniversite öğrencisi katılmıştır. Veriler Çocukluk Çağı Travma Ölçeği,  Yeme Tutumu Ölçeği ve Demografik Bilgi Formu aracılığı ile toplanmıştır. Araştırmada test edilmesi planlanan hipotetik model ilişkisel tarama modeline göre tasarlanmıştır. Analiz sonuçlarına göre, çocukluk çağı travma biçimlerinden fiziksel ihmalin zayıflıkla aşırı uğraşma; cinsel istismarın ise diyet yapma tutumu üzerinde yordayıcı etkisi olduğu saptanmıştır. Ayrıca, kadın cinsiyetinin şişmanlık kaygısı ve sosyal baskı algılama; vücut kitle indeksinin şişmanlık kaygısı ve sosyal baskı algılama üzerinde anlamlı bir yordama etkisine sahip olduğu bulunmuştur. Sonuçlar, klinikte yeme bozukluğu gösteren bireylerde cinsel istismar ve fiziksel ihmalin değerlendirilmesi ve tedavide yer verilmesi muhtemel müdahalelerin hazırlanmasında yol gösterici olabileceğine işaret etmektedir.
Bağlanma, Duygu Düzenleme Süreçleri ve Cinsel İşlev Bozukluğu Arasındaki İlişki: Bir Model Önerisi
Authors: ULUYOL Fatma Mahperi
Published: January 2020

Ergenlikten başlayarak kişinin yaşamında önemi gittikçe artan cinsel yaşam psikolojik, sosyolojik ve biyolojik temeli olan pek çok faktörden etkilenmektedir. Bu çalışmada alanyazında sıklıkla çalışılan güvensiz bağlanma örüntüleri ve cinsel işlev sorunları arasındaki ilişkiye açıklama getirmek için duygu düzenleme süreçleri ve olumlu-olumsuz deneyimlerin rolü Yapısal Eşitlik Modellerinden Yol Analizi ile test edilmiştir. Araştırmanın örneklemini yaşları 18 ile 31 arasında değişen, Golombok Rust Cinsel Doyum Ölçeği’nden 35 ve üstü puan alan 201 kadın oluşturmaktadır. Doğrudan ilişkiler incelendiğinde güvensiz bağlanma örüntüsü sergileyen kadınların olumsuz deneyimlerinin artması, cinsel işlev bozukluğu düzeyinin artması ile; duygu düzenleme güçlüklerinin artması ise cinsel işlev bozukluğu düzeyinin düşmesi ile ilişkili bulunmuştur. Fakat dolaylı ve toplam etkiler incelendiğinde duygu düzenleme süreçlerinde yaşanan güçlükler cinsel işlev bozukluğu düzeyi ile pozitif yönde ilişkilidir. Ayrıca, kaçınıcı bağlanma örüntüsü cinsel işlev bozukluğu düzeyini kaygılı bağlanma örüntüsüne kıyasla daha yüksek düzeyde yordamıştır.
Farklı Göreli Yoksunluk Seviyelerinde Başa Çıkma Stratejileri ve Öznel İyi Oluş Arasındaki İlişki
Authors: ÖZDEMİR Fatih
Published: January 2020

Bu araştırmanın amacı demografik değişkenleri (cinsiyet, yaş ve algılanan sosyo-ekonomik statü) kontrol ederek, düşük seviyede ve yüksek seviyede yoksun örneklemlerde, başa çıkma stratejileri (çözüme dönük başa çıkma, duygusal başa çıkma ve kaçınmacı başa çıkma) ve öznel iyi oluşun bilişsel ve duygusal boyutları (sırasıyla, yaşam doyumu ve algılanan stres) arasındaki ilişkileri incelemektir. Araştırma verisi, yaşları 18 ile  26 arasında değişen 218  düşük seviyede yoksun ve 193 yüksek seviyede yoksun bireyden toplanmıştır. Temel araştırma hipotezleri hiyerarşik regresyon analizleriyle test edilmiştir. Hipotezlerle tutarlı olarak, göreli yoksunluk seviyesine bakmaksızın, çözüm odaklı başa çıkma stratejisi öznel iyi oluşla olumlu yönde ilişkiliyken, duygusal başa çıkma stratejisi olumsuz yönde ilişkili bulunmuştur. Kaçınmacı başa çıkma stratejisi ve öznel iyi oluş arasındaki ilişkinin anlamlılığı ise algılanan yoksunluk seviyesine bağlıdır. Bu araştırma yoksunluk gibi olumsuz bir durumla başa çıkma sürecinde doğru bilişsel tepkilerin verilmesinin önemini göstermiştir. Bulgular başa çıkma stratejisinin etkinliğinin olumsuz durumun ciddiyeti ve bireyin bilişsel ve duygusal ihtiyaçlarıyla ilişkili olduğunu desteklemişti
Psikodrama Teknikleri ile Bütünleştirilmiş Etkileşim Grubu Uygulamasının Karşılıklı Bağımlılık Üzerindeki Etkisi
Authors: ULUSOY DOĞMUŞ Yağmur , GÜÇRAY S. Sonay
Published: January 2020

Bu araştırmada psikodrama teknikleri ile bütünleştirilmiş etkileşim grubu uygulamasının karşılıklı bağımlılık üzerindeki etkisini incelemek amaçlanmıştır. Bu araştırmada, karma desenlerden, iç içe desen yöntemi kullanılmıştır. Bu araştırmada ön-test, son-test ve izleme ölçümü yapılan deney ve kontrol grubundan oluşan yarı deneysel bir çalışma yapılmıştır. Araştırmanın çalışma grubu, 14’ü deney, 14’ü kontrol grubuna tesadüfü olarak atanan 28 kadın psikolojik danışman adayından oluşmaktadır. Bu araştırmanın nicel verilerini toplamak için Bileşik Karşılıklı Bağımlılık Ölçeği kullanılmış; nitel verileri toplamak için odak grup görüşmesi yapılmıştır. Deney grubuna toplam 14 oturumluk psikodrama teknikleri ile bütünleştirilmiş etkileşim grubu uygulaması yapılmıştır. Kontrol grubuna hiçbir işlem uygulanmamıştır. Yapılan analizler sonucunda, nicel bulgular deneysel çalışmanın karşılıklı bağımlılık, kendini feda etme ve duyguları bastırma puanlarını azaltmada etkili olduğunu ortaya koymuştur. Ancak kişilerarası kontrol puanlarını azaltmada etkili olmadığını ortaya koymuştur. Nitel bulguların, nicel bulgularla benzerlik gösterdiği görülmüştür.
Trans Bireylere Yönelik Tutum Ölçeği'nin Türkçe Geçerlik ve Güvenirlik Çalışması
Authors: AKDEMİR Seda , GÖLGE Zeynep Belma
Published: January 2020

Bu çalışmanın amacı Trans Bireylere Yönelik Tutum Ölçeği’nin Türkçe’ye uyarlanmasıdır. Çalışma 218 üniversite öğrencisi ile yürütülmüştür. Katılımcılardan Cinsiyetçilik ve Transfobi Ölçeği, Walch ve arkadaşları tarafından geliştirilen Trans Bireylere Yönelik Tutum Ölçeği ve araştırmacılar tarafından hazırlanan katılımcı bilgi formun cevaplanması istenmiştir. Ölçeğin yapı geçerliliği öncelikle açımlayıcı faktör analizi (AFA), ardından ise doğrulayıcı faktör analizi (DFA) ile sınanmış olup, ölçüt geçerliğinin sınanması için Pearson korelasyon katsayısına bakılmıştır. Ölçeğe ilişkin güvenilirlik değeri ise Cronbach alfa katsayısı ile hesaplanmıştır. Katılımcıların 158’inin (%72.5) cinsiyetini kadın, 58’i (%26.6) erkek ve 1’i (%0.5) diğer olarak tanımlamıştır. DFA sonucunda uyum iyiliği değerlerinin kabul edilebilir düzeyde olduğu görülmüştür (SRMR = .048, X2 = 437.534, df = 170, p <.001 X2/df = 2.574, IFI = 90, CFI = 90, RMSEA =.08). Madde faktör yüklerinin en düşük .50 en yüksek .84 olduğu görülmüştür. AFA ve DFA sonucunda ölçeğin tek faktörlü ve orjinal yapısına uyumlu olduğu tespit edilmiştir. Ölçeğe ait Cronbach alfa değeri .95, Guttman eşdeğer yarılar güvenirlik katsayısı ise .93 olarak hesaplanmıştır. Yapılan istatiksel analizler doğrultusunda Trans Bireylere Yönelik Tutum Ölçeği’nin Türk popülasyonu için güvenilir ve geçerli olduğu kabul edilmiştir.
Pediatrik Astımda Kaygı, Depresyon, Somatizasyon ve Yaşam Kalitesi ile Serum IgE Düzeyi İlişkisi
Authors: AKTAN Z. Deniz , BERK H.özlem Sertel , ERDOGAN Fırat , ÖKTEM Sedat
Published: January 2020

Bu çalışmanın amacı çocuklarda astım şiddeti ile depresyon, açık kaygı, yaşam kalitesi, somatizasyon gibi değişkenleri ve astımda bağışıklık sistemi belirleyicilerinden olan IgE düzeyi arasındaki olası ilişkiyi analiz etmektir. Toplamda 141 katılımcının bulunduğu bu çalışmanın örneklemini 6-12 yaş arası astımlı çocuklar oluşturmaktadır. Katılımcıların ruh sağlığı belirtilerini değerlendirmek adına Çocuk Depresyon Ölçeği, Çocuklar İçin Açık Kaygı Ölçeği, Pediatrik Astımda Yaşam Kalitesi Ölçeği ve Davranış Değerlendirme Ölçeğinin Somatik Yakınmalar Alt Ölçeği kullanılmıştır. Astım şiddeti, astım kontrol düzeyi üzerinden uzman hekimlerce değerlendirilirken, Serum IgE düzeyleri ELISA tekniği kullanılarak elde edilmiştir. Katılımcıların astım düzeyleri ile anksiyete, depresyon, yaşam kalitesi, somatizasyon ve Serum IgE düzeyleri, arasındaki ilişkileri belirlemek amacıyla yapılan analizlerden elde edilen verilere göre, kontrolsüz astım grubunda bulunan katılımcıların açık kaygı puanlarıyla IgE düzeyleri arasında orta düzeyde anlamlı yüksek korelasyon olduğu görülmüştür. Araştırma verileri değerlendirildiğinde, ruh sağlığı değişkenlerinden açık kaygı ile astımda bağışıklık sistemi belirleyicilerinden olan IgE düzeyi arasındaki ilişkinin, astım hastalığının şiddeti üzerinde etkili olabileceği yönünde veriler elde edildiğinden, gelecek araştırmaların söz konusu ilişkiyi psikonöroimmunolojik açıdan derinlemesine incelemesi önerilmektedir.
Los voluntarios suizos en las Brigadas Internacionales (1936-1938) = Swiss Volunteers in International Brigades (1936-1938)
Authors: Ramón Carrión Manuel Alberto
Published: January 2020

Resumen: Durante la Guerra Civil española miles de extranjeros lucharon en ambos ejércitos. El de Franco recibió principalmente militares regulares de Italia (más de 70.000) y de Alemania (unos 19.000 en varios reemplazos). Las Brigadas Internacionales constituyeron el contingente más numeroso que apoyó a la República con unos 35.000 voluntarios de una cincuentena de países. En las BBII se alistaron unos 800 suizos de los que murieron en torno a 200. Pocas personas en España conocen la existencia de este contingente helvético, cuyos miembros tuvieron serios problemas al regresar a su país porque Suiza había prohibido combatir con los ejércitos españoles contendientes para reafirmar su tradicional política de neutralidad.Palabras clave: Brigadas Internacionales, voluntarios suizos, neutralidad, financieros suizos, dispersión lingüística.Abstract: During the Spanish Civil War thousands of foreigners fought in both armies. Franco received mainly regular military from Italy (more than 70,000) and from Germany (19,000 in several replacements). The International Brigades constituted the largest contingent that supported the Republic by framing some 35,000 volunteers from around fifty countries. Among them, about 800 Swiss, of those who died around 200. Few people in Spain know the existence of this Swiss contingent, whose members had serious problems returning to their country because Switzerland had forbidden to support or fight in the Spanish armies to reaffirm its traditional neutrality policy.Keywords: International Brigades, Swiss volunteers, neutrality, Swiss financial, linguistic dispersion.
Maitane Ostolaza, La terre des Basques : Naissance d’un paysage (1800-1936), Rennes, Presses universitaires de Rennes, 2018, 334 páginas
Authors: Ramón Gabriel María
Published: January 2020

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Cristián Cerón Torreblanca (coord.), Los límites del Estado: la cara oculta del poder local, Universidad de Málaga, UMA Editorial, 2018, 273 páginas
Authors: Blanco Fajardo Sergio
Published: January 2020

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Laura Branciforte, Donne in onda nel ventenio fascista. Tra modernità e tradizione, Soveria Manelli, Editorial Rubbettino, 2018, 246 páginas
Authors: Jurado Javier
Published: January 2020

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David Ginard Ferón, Aurora Picornell, feminismo, comunismo y memoria republicana en el siglo XX, Granada, Comares Historia, 2018, 119 páginas
Authors: Branciforte Laura
Published: January 2020

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Prediction of Flow Characteristics in the Bubble Column Reactor by the Artificial Pheromone-Based Communication of Biological Ants
Authors: Shamshirband Shahab , Babanezhad Meisam , Mosavi Amir , Nabipour Narjes , Hajnal Eva , Nadai Laszlo , Chau Kwok-wing
Published: January 2020

In order to perceive the behavior presented by the multiphase chemical reactors, the ant colony optimization algorithm was combined with computational fluid dynamics (CFD) data. This intelligent algorithm creates a probabilistic technique for computing flow and it can predict various levels of three-dimensional bubble column reactor (BCR). This artificial ant algorithm is mimicking real ant behavior. This method can anticipate the flow characteristics in the reactor using almost 30 % of the whole data in the domain. Following discovering the suitable parameters, the method is used for predicting the points not being simulated with CFD, which represent mesh refinement of Ant colony method. In addition, it is possible to anticipate the bubble-column reactors in the absence of numerical results or training of exact values of evaluated data. The major benefits include reduced computational costs and time savings. The results show a great agreement between ant colony prediction and CFD outputs in different sections of the BCR. The combination of ant colony system and neural network framework can provide the smart structure to estimate biological and nature physics base phenomena. The ant colony optimization algorithm (ACO) framework based on ant behavior can solve all local mathematical answers throughout 3D bubble column reactor. The integration of all local answers can provide the overall solution in the reactor for different characteristics. This new overview of modelling can illustrate new sight into biological behavior in nature.
Klein's Trace Inequality and Superquadratic Trace Functions
Authors: Kian Mohsen , Alomari Mohammad W.
Published: January 2020

We show that if $f$ is a non-negative superquadratic function, then $A\mapsto\mathrm{Tr}f(A)$ is a superquadratic function on the matrix algebra. In particular, \begin{align*} \tr f\left( {\frac{{A + B}}{2}} \right) +\tr f\left(\left| {\frac{{A - B}}{2}}\right|\right) \leq \frac{{\tr {f\left( A \right)} + \tr {f\left( B \right)} }}{2} \end{align*} holds for all positive matrices $A,B$. In addition, we present a Klein's inequality for superquadratic functions as $$ \mathrm{Tr}[f(A)-f(B)-(A-B)f'(B)]\geq \mathrm{Tr}[f(|A-B|)] $$ for all positive matrices $A,B$. It gives in particular improvement of Klein's inequality for non-negative convex function. As a consequence, some variants of the Jensen trace inequality for superquadratic functions have been presented.
Physicochemical Properties of Dried Ginseng Powder Manufactured using Different Roasting Pretreatments and Cryogenic Milling conditions
Authors: Jeong Hayeong , Park Dong Hyeon , Seo Han Geuk , Choi Mi-Jung , Cho Youngjae
Published: January 2020

This study was aimed at investigating the effects of roasting and cryogenic milling on particle size, water solubility, and amount of bioactive components in ginseng root. Samples were pulverized by cryogenic milling, and one treatment condition was selected for each size range (10-50 μm, and >50 μm). The selected samples were roasted at different temperatures (160-200 °C) followed by cryogenic milling. Powdered samples were analyzed for their physicochemical characteristics. Results revealed that roasted samples exhibited significantly smaller particle size than controls (not roasted, p<0.05), and the particle size of roasted samples decreased with increase in roasting temperature until flocculation occurred around 180-190 °C. With decrease in particle size of ginseng; water solubility index, antioxidant activity, total polyphenol content, and total polysaccharide content were observed to increase. Ginseng samples showed an increasing trend in antioxidant activity with decreasing particle size (p>0.05) with significantly higher values for all roasted samples compared to the controls (p<0.05). Non-polar ginsenosides such as Rg2(S), Rg2(R), Rg3(S), Rg3(R), and Rh1(S) showed an increase in temperature-dependent manner. This study revealed that roasting at certain temperature range with cryogenic milling has positive effects on ginseng by reducing its particle size, and increasing water solubility and bioactive components.
Meeting Report: Instituto Gulbenkian de Ciência-Institut Curie Young Scientists' Retreat 2019
Authors: Correia Rion Brattig , Josserand Manon , Vieira Diana V. , Andus Sara , Arbore Roberto , Cachoux Victoire , Carbonetto Maria Belén , Cristo Inês , de Juan Alba , Mani Satish Kailasam , Marzullo Marta , Perestrelo Tânia , Pineault Kyriel , Stajic Dragan
Published: January 2020

This paper report presents the interdisciplinary science showcased at the Young Scientists Retreat 2019. The retreat was jointly organized by young researchers from Instituto Gulbenkian de Ciência (Portugal) and Institut Curie (France) and took place in Pedrógão Pequeno, a small village in the central region of Portugal in September 2019. Three keynote speakers were invited to present their work, Alfonso Martinez-Arias, Biola Javierre Martínez, and Sara Magalhães. In addition, accepted talks and posters from young researchers were presented at the retreat. Talks were organized in sessions, which included: epigenetics and evolution, immunology, cell biology and metabolism, biostatistics and public health, biophysics, proliferation and morphogenesis, and cell polarity. A post-retreat survey, complied both by IGC attendees as well as a sample of non-attendees, discovered the existence of barriers that prevented the full participation of some junior scientists, especially female postdocs and postdocs with families. We discuss ways in which future retreats could help address this and additional issues common to young researchers in general.
Co-Existance of Lightning Generated Whistlers, Hiss and Lower Hybrid Noise Observed by e- POP (SWARM-E) –RRI
Authors: Maxworth Ashanthi , Gołkowski Mark , Hussey Glenn
Published: January 2020

Whistler mode waves play a major role in regulating the lifetime of trapped electrons in the Earth's radiation belts. Specifically, whistler mode hiss waves are one of the mechanisms that maintains the slot region between the inner and outer radiation belts. The generation mechanism of hiss is a topic still under debate with at least three prominent theories present in the literature. Lightning generated whistlers in their ducted or non-ducted modes, are considered to be one of the possible sources of hiss. We present a study of new observations from the Radio Receiver Instrument (RRI) on the Enhanced Polar Outflow Probe (ePOP: currently known as SWARM-E). RRI consists of two orthogonal dipole antennas, which enables polarization measurements, when the satellite boresight is parallel to the geomagnetic field. Here we present 75 passes of ePOP - RRI from 2014 - 2018, in which lightning whistlers and hiss waves were observed. In more than 50% of those passes hiss is found to co-exist with the lightning whistlers. Moreover, the whistler observations are correlated with observations of wave power at the lower-hybrid resonance. The observations and a whistler mode ray-tracing study suggest that multiple-hop lightning induced whistlers can be a source of hiss and plasma instabilities in the magnetosphere.
Area-Based Conservation in the 21st Century
Authors: Maxwell Sean L. , Cazalis Victor , Dudley Nigel , Hoffmann Michael , Rodrigues Ana S.L. , Stolton Sue , Visconti Piero , Woodley Stephen , Maron Martine , Strassburg Bernardo B.N. , Wenger Amelia , Jonas Harry D. , Venter Oscar , Watson James E.M.
Published: January 2020

Humanity will soon define a new era for nature – one that seeks to correct decades of underwhelming responses to the global biodiversity crisis. Area-based conservation efforts, which include both protected areas and other effective area-based conservation measures, are likely to extend and diversify. But persistent shortfalls in ecological representation, management effectiveness and measurable biodiversity outcomes diminish the potential role of area-based conservation in stemming biodiversity loss. Here we show how protected area expansion by governments since 2010 has had limited success in increasing biodiversity coverage, and identify four emergent issues that –if addressed – will enhance the performance of area-based conservation post-2020. We close with recommendations for a broad biodiversity agenda that maximises the potential of area-based conservation. Parties to the Convention on Biological Diversity must recognise that area-based conservation primarily focuses on local threats to species and ecosystems, and needs enhanced emphasis on biodiversity outcomes to better track and fund its contribution to global conservation efforts.
A Bayesian Monte-Carlo Uncertainty Model for Assessment of Shear Stress Entropy
Authors: Kazemian-Kale-Kale Amin , Gholami Azadeh , Rezaie-Balf Mohammad , Mosavi Amir , A. Sattar Ahmed , Gharabaghi Bahram , Bonakdari Hossein
Published: January 2020

The entropy models have been recently adopted in many studies to evaluate the distribution of the shear stress in circular channels. However, the uncertainty in their predictions and their reliability remains an open question. We present a novel method to evaluate the uncertainty of four popular entropy models, including Shannon, Shannon-Power Low (PL), Tsallis, and Renyi, in shear stress estimation in circular channels. The Bayesian Monte-Carlo (BMC) uncertainty method is simplified considering a 95% Confidence Bound (CB). We developed a new statistic index called as FREEopt-based OCB (FOCB) using the statistical indices Forecasting Range of Error Estimation (FREE) and the percentage of observed data in the CB (Nin), which integrates their combined effect. The Shannon and Shannon PL entropies had close values of the FOCB equal to 8.781 and 9.808, respectively, had the highest certainty in the calculation of shear stress values in circular channels followed by traditional uniform flow shear stress and Tsallis models with close values of 14.491 and 14.895, respectively. However, Renyi entropy with much higher values of FOCB equal to 57.726 has less certainty in the estimation of shear stress than other models. Using the presented results in this study, the amount of confidence in entropy methods in the calculation of shear stress to design and implement different types of open channels and their stability is determined.
Mechanistic Insights into the Curcumin-Mediated Neuroprotection in Alzheimer’s Disease: An Integrated System Pharmacology and Molecular Simulation Study
Authors: Hannan Md. Abdul , Dash Raju , Haque Md. Nazmul , Sohag Abdullah Al Mamun , Moon Il Soo
Published: January 2020

Curcumin is one of the bioactive metabolites of turmeric (Curcuma longa), known for its pleiotropic pharmacological actions, including antioxidant and anti-inflammation, anticholinesterase, immunomodulation, and neuroprotection. Substantial evidence suggests the therapeutic benefits of curcumin against neurodegenerative disorders, including Alzheimer’s disease (AD), acting on a diverse array of brain targets that make the molecular mechanisms complicated. System biology level-investigation could potentially present a comprehensive molecular mechanism to delineate the neuropharmacological action of curcumin. In this study, we used integrated system pharmacology and molecular simulation analysis to gain insights into the underlying mechanism of curcumin action against AD. Network pharmacology study identified curcumin-targeted potential cellular pathways such as phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) signaling, neurotrophin signaling, toll-like receptor (TLR) signaling, and autophagy, and proteins such as tropomyosin receptor kinase B (TrkB), liver X-receptor-beta (LXR-β), estrogen receptor-β (ER-β), mammalian target of rapamycin (mTOR), TLR-2, N-methyl-D-acetate receptor subunit 2B (GluN2B), β-secretase and glycogen synthase kinase-3β (GSK-3β), which are intimately associated with neuronal growth and survival, immune response, and inflammation. Moreover, the molecular modeling further verified that curcumin showed a significant binding affinity to mTOR, TrkB, LXR-β, TLR-2, ER-β, GluN2B, β-secretase, and GSK-3β, which are the crucial regulators of molecular and cellular processes associated with AD. Together, the present system pharmacology and in silico findings demonstrate that curcumin might play a significant role in modulating AD-pathobiology, supporting its therapeutic application for the prevention and treatment of AD.
Synthesis of ZnO-NPs Using Convolvulus Leaf Extract and Proving Its Efficiency as an Inhibitor for Carbon Steel Corrosion in 1M HCl
Authors: Al-Senani Ghadah
Published: January 2020

This paper studies the use of zinc oxide nanoparticles (ZnO-NPs) synthesized using an extract of convolvulus leaves and expired ZnCl2, as an efficient inhibitor for carbon steel corrosion in 1M HCl solution. ZnO-NPs are characterized by Fourier-transform infrared spectrophotometer (FTIR) and UV–Vis analysis. The technique of weight loss, potentiodynamic polarization, and electrochemical impedance spectroscopy (EIS) has also been used to investigate the prevention of carbon steel corrosion in 1M HCl. The results showed that the efficiency of restraint increased when the concentration of ZnO-NPs was raised to 91% and that the inhibition efficiency is still high despite its decrease at high temperature, and it acts as a mixed-type inhibitor A sample of carbon steel with the protective inhibitor layer on top was immersed for 20 hours and observed; an increase in the charge transfer resistance (Rct) and stability of the inhibitor was noticed after 6 hours. Adsorption isotherm models demonstrated that the inhibitor adsorption mechanism on the carbon steel surface followed Langmuir, more than Freundlich and Temkin, behavior. The thermodynamic parameters showed that the adsorption process is a mixed adsorption, spontaneous, and exothermic. The results illustrated that the acid medium was a strong inhibitor of carbon steel corrosion. Scanning electron microscope (SEM) showed that the ZnO-NPs formed a good protective film on the carbon steel surface.
Design of an Unsupervised Machine Learning-Based Movie Recommender System
Authors: Cintia Ganesha Putri Debby , Leu Jenq-Shiou , Seda Pavel
Published: January 2020

This research aims to determine the similarities in groups of people to build a film recommender system for users. Users often have difficulty in finding suitable movies due to the increasing amount of movie information. The recommender system is very useful for helping customers choose a preferred movie with the existing features. In this study, the recommender system development is established by using several algorithms to obtain groupings, such as the K-Means algorithm, birch algorithm, mini-batch K-Means algorithm, mean-shift algorithm, affinity propagation algorithm, agglomerative clustering algorithm, and spectral clustering algorithm. We propose methods optimizing K so that each cluster may not significantly increase variance. We are limited to using groupings based on Genre and, Tags for movies. This research can discover better methods for evaluating clustering algorithms. To verify the quality of the recommender system, we adopted the mean square error (MSE), such as the Dunn Matrix and Cluster Validity Indices, and social network analysis (SNA), such as Degree Centrality, Closeness Centrality, and Betweenness Centrality. We also used Average Similarity, Computational Time, Association Rule with Apriori algorithm, and Clustering Performance Evaluation as evaluation measures to compare method performance of recommender systems using Silhouette Coefficient, Calinski-Harabaz Index, and Davies-Bouldin Index.
Micro and Mini Generation from Biomass: A Sustainable Alternative for Brazilian Agribusiness
Authors: Pereira Ribeiro Marcia Carla , Paglia Nadal Caroline , Rocha Junior Weimar Freire , Fragoso Rui Manuel De Sousa , Lindino Cleber Antonio
Published: January 2020

The present article discusses the institutional model adopted in Brazil regarding energy production through biomass. The theoretical-empirical method is used to conclude that the model's difficulties can be overcome by adopting a network of contracts capable of subjecting renewable energy generation to an energy compensation model.
Inter-Molecular Electrostatic Interactions Stabilizing the Structure of the PD-1/PD-L1 Axis: A Structural Evolutionary Perspective
Authors: Li Wei
Published: January 2020

PD-1/PD-L1 axis is one key therapeutic target against tumor cell immune escape. Structurally essential to the PD-1/PD-L1-linked immune escape is the binding interface of the PD-1/PD-L1 complex structure. Incorporating currently available PD-1/PD-L1-related experimental structures, this article unveils two sets of experimentally observed inter-molecular electrostatic interactions which stabilize the binding interface of the PD-1/PD-L1 complex structure. For the first time, this article proposes an evolutionary structural hypothesis that, as a result of natural selection, PD-1 is able to genetically mutate itself to structurally disrupt the PD-1/PD-L1 axis towards the restoration of T cell-mediated anti-tumor immunity.
Complete Removal of Arbitrarily Strong and Arbitrarily Located Auto Correlation Artifacts in Spectral Domain Optical Coherence Tomography: Demonstration of an Efficient and Cost Effective Technique
Authors: Nandakumar Hari , Mallick SatyaPrasanna , Srivastava Shailesh
Published: January 2020

The proof-of-principle demonstration of a simple, yet effective method of autocorrelation artifact removal for optical coherence tomography (OCT) is presented using a custom-designed parallel spectral-domain OCT (SD-OCT) instrument. Our real-time method is based on time-averaged sampling of a sinusoidal phase modulation in the reference arm. Unlike other existing methods, our technique can completely eliminate arbitrarily located, arbitrarily strong autocorrelation artifacts.
A Local Spherical Coordinate System Approach to Protein 3D Structure Description
Authors: Li Wei
Published: January 2020

To date, Cartesian (x, y, z) coordinate system (CCS) has been the default approach to geometrically specify atomic spatial positions in protein structures since the launch of Protein Data Bank (PDB) in 1971. To this end, this paper proposes a local spherical coordinate system (SCS) approach as an alternative to the default approach and a previously reported global SCS approach. The local SCS approach here requires only two parameters (θ and φ), instead of x, y and z as required by the default CCS approach. Essentially, CCS and SCS are like the two sides of one coin, i.e., geometric coordinate system for three-dimensional position specification. Therefore, this paper furthermore argues that it is time to flip the coin over, and have a look at the other side of the coin, e.g., the local SCS approach, which possesses an intrinsically lower degree of descriptional complexity than that of the default CCS approach, and constitutes a potentially useful alternative perspective for all protein structural research field.
Evaluation of a Brief Intervention to Reduce Cell Phone Use
Authors: Piper Brian J. , Daily Shay M. , Martin Sarah L. , Martin Maurice W.
Published: January 2020

Excessive cell phone use contributes to distracted driving, may increase risk for automobile accidents, and a minority of mobile phone users exhibit behaviors consistent with technological addiction. The purpose of this study was to determine whether cell phone beliefs and behaviors could be changed by a brief educational encounter. The Theory of Reasoned Action provided a lens for viewing attitudes and behavior. A one-week pre-post design with a thirty-day follow-up was used with participants (N = 215, 67.0% female, age = 20.0 + 1.6) assigned to a peer led intervention or comparison groups. The intervention included cell-phone educational materials. A short index of cell phone behavior was developed which showed good internal consistency with a Cronbach’s alpha of .81. The intervention group “agreed” or “strongly-agreed” more than the comparison group on five of the seven areas of cell phone beliefs and behaviors ( p < 0.05, item Cohen’s d = .32 to .47, total d = .50) at one-week following receipt of informational materials. We conclude that attitudes and behaviors regarding cell phones are malleable and susceptible to change in young-adults following a brief psychoeducational intervention.
The Endogenous Opioid System in Schizophrenia and Treatment Resistant Schizophrenia: Increased Plasma Endomorphin 2, and κ and μ Opioid Receptors are Associated with Interleukin-6
Authors: Moustafa Shatha Rouf , Al-Rawi Khalid F. , Al-Dujaili Arafat Hussein , Supasitthumrong Thitiporn , Al-Hakeim Hussein Kadhem , Maes Michael
Published: January 2020

Background: Activation of the immune-inflammatory response system (IRS) and the compensatory immune-regulatory system (CIRS) play a key role in SCZ and treatment resistant SCZ. There are only few data on immune and endogenous opioid system (EOS) interactions in SCZ and treatment resistant SCZ.Aim of the study: We examined serum β-endorphin, endomorphin-2 (EM2), mu-opioid (MOR) and kappa-opioid (KOR) receptors, and interleukin (IL)-6 and IL-10 in 60 non responders to treatment (NRTT), 55 partial RTT (PRTT) and 43 normal controls.Results: Serum EM2, KOR, MOR, IL-6 and IL-10 were significantly increased in SCZ as compared with controls. β-endorphin, EM2, MOR and IL-6 were significantly higher in NRTT than in PRTT. There were significant correlations between IL-6, on the one hand, and β-endorphin, EM2, KOR, and MOR, on the other, while IL-10 was significantly correlated with MOR only. A large part of the variance in negative symptoms, psychosis, hostility, excitation, mannerism, psychomotor retardation and formal thought disorders was explained by the combined effects of EM2 and MOR with or without IL-6 while increased KOR was significantly associated with all symptom dimensions. Increased MOR, KOR, EM2 and IL-6 were also associated with neurocognitive impairments including in episodic, semantic and working memory and executive functions.Conclusion: The EOS contributes to SCZ symptomatology, neurocognitive impairments and a non-response to treatment. In SCZ, EOS peptides/receptors may exert CIRS functions, whereas increased KOR levels may contribute to the pathophysiology of SCZ and EM2 and KOR to a non-response to treatment.
Acute Gout Attack Immediately After Total Knee Arthroplasty
Authors: Moon Hyun-Soo , Yoo Ju-Hyung , Park Sang-Hoon , Jung Se-Han , Choi Chong-Hyuk
Published: January 2020

Case:

We report a case of acute gouty arthritis-mimicking infection that occurred immediately after right total knee arthroplasty in a 73-year-old man. Repetitive laboratory tests showed acute inflammation and did not easily distinguish acute gout from bacterial infection. Surgical treatment was undertaken for diagnostic and therapeutic purposes. A large amount of chalky whitish crystals suggestive of acute gout was found in both knees without the suspicion of bacterial infection, and thorough irrigation and debridement were performed.

Conclusions:

Although conservative treatment is generally administered for acute gouty arthritis, early surgical intervention may ensure a good clinical result in a prosthetic joint.
Synchronous Multifocal Necrotizing Fasciitis
Authors: Wade Sean M. , Henriques Matthew E. , Dingle Marvin E. , Tintle Scott M. , Souza Jason M. , D'Alleyrand Jean-Claude
Published: January 2020

Case:

An immunocompetent 43-year-old man was diagnosed with necrotizing fasciitis of his forearm. Despite receiving appropriate treatment, his clinical condition continued to deteriorate. Further evaluation revealed subsequent proliferation of the infection to multiple noncontiguous areas of the body consistent with a rare condition known as synchronous multifocal necrotizing fasciitis. Prompt identification, followed by serial debridements of all affected areas, ultimately saved the patient's life.

Conclusion:

This unusual multifocal presentation of necrotizing fasciitis can produce diagnostic uncertainty and delay life-saving treatment. Early recognition, followed by prompt treatment, is paramount for reducing morbidity and mortality associated with this devastating infection.
Catastrophic Failure of a MiniHip Femoral Stem
Authors: Melnic Christopher M. , Aurigemma Philip , Lee Jo Ann , Dwyer Maureen , Bedair Hany S.
Published: January 2020

Case:

The patient is a 63-year-old man who previously underwent a right total hip arthroplasty with the Corin MiniHip femoral stem. Within the first few months postoperatively, he had a fall that resulted in subsidence of his femoral prosthesis and subsequent revision shortly thereafter with a 10-mm skirted cobalt chrome femoral head. Eight years after the index procedure, the patient heard a crack and then collapsed while putting on bicycle shorts. Workup demonstrated a fracture of the stem at the base of the neck of the implant. Femoral stem revision with a diaphyseal engaging, modular implant, and dual mobility hip construct was performed.

Conclusion:

Atraumatic catastrophic failure of the femoral stem implant may be associated with long skirted femoral heads that create excessive bending moments on the stem and revision surgery.
An operon consisting of a P-type ATPase gene and a transcriptional regulator gene responsible for cadmium resistances in Bacillus vietamensis 151-6 and Bacillus marisflavi 151-25
Authors: Yu Xiaoxia , Ding Zundan , Ji Yangyang , Zhao Jintong , Liu Xiaoqing , Tian Jian , Wu Ningfeng , Fan Yunliu
Published: January 2020

Background: Cadmium (Cd) is a severely toxic heavy metal to most microorganisms. Many bacteria have developed Cd 2+ resistance. Results: In this study, we isolated two different Cd 2+ resistance Bacillus sp . strains, Bacillus vietamensis 151-6 and Bacillus marisflavi 151-25 , which could be grown in the presence of Cd 2+ at concentration up to 0.3 mM and 0.8 mM, respectively. According to the genomic sequencing, transcriptome analysis under cadmium stress, and other related experiments, a gene cluster in plasmid p25 was found to be a major contributor to Cd 2+ resistance in B. marisflavi 151-25. The cluster in p25 contained orf4802 and orf4803 which encodes an ATPase transporter and a transcriptional regulator protein, respectively. Although 151-6 has much lower Cd 2+ resistance than 151-25, they contained similar gene cluster, but in different locations. A gene cluster on the chromosome containing orf4111 , orf4112 and orf4113 , which encodes an ATPase transporter, a cadmium efflux system accessory protein and a cadmium resistance protein, respectively, was found to play a major role on the Cd 2+ resistance for B. vietamensis 151-6. Conclusions: This work described cadmium resistance mechanisms in newly isolated Bacillus vietamensis 151-6 and Bacillus marisflavi 151-25. Based on homologies to the cad system (CadA-CadC) in Staphylococcus aureus and analysis of transcriptome under Cd 2+ induction, we inferred that the mechanisms of cadmium resistance in B. marisflavi 151-25 was as same as the cad system in S. aureus . Although Bacillus vietamensis 151-6 also had the similar gene cluster to B. marisflavi 151-25 and S. aureus , its transcriptional regulatory mechanism of cadmium resistance was not same. This study explored the cadmium resistance mechanism for B. vietamensis 151-6 and B. marisflavi 151-25 and has expanded our understanding of the biological effects of cadmium.
Echocardiographic evidence of left ventricular untwisting-filling interplay
Authors: Hodzic Amir , Garcia Damien , Saloux Eric , Ribeiro Paula A.B. , Ethier Amélie , Thomas James D. , Milliez Paul , Normand Hervé , Tournoux Francois
Published: January 2020

The authors have withdrawn this preprint from Research Square