bluuebunny/crossref_metadata_2025 huggingface dataset:
Volunteer Position Descriptions: Tools for Generating Members, Volunteers, and Leaders in Extension
Authors: Culp Ken
Published: July 2023

Successful organizations involve members, volunteers, and leaders who engage their talents and interests. Members, volunteers, and leaders all have important roles in the organization and are dependent upon each other to fulfill their roles. Community involvement is necessary for an organization to achieve its mission, vision, and purpose. The mission, vision, and purpose are identified through a needs assessment. After assessing needs and developing position descriptions, potential members, volunteers ,or leaders are identified and recruited. Individual interests, knowledge, skills, and backgrounds are explored through the selection and screening processes. Selection is based upon the individual's ability to perform the task.
Assessing Extension's Ability to Promote Family Forests as a Woody Biomass Feedstock in the Northeast United States
Authors: Germain Rene’ , Ghosh Chandrani
Published: July 2023

The study reported here surveyed Extension educators' awareness and knowledge of woody biomass energy and assessed their desire and ability to reach out to family forest owners—a critical feedstock source. The results indicate Extension educators are aware of the potential of woody biomass to serve as a renewable source of energy. Respondents representing forestry/natural resources disciplines registered higher awareness and willingness to diffuse scores than agriculture, horticulture, and community development educators. The study provides a baseline measurement of awareness and knowledge of woody biomass as an energy source, and desire to promote forest management for woody biomass to FFO.
Immunomodulating Phytochemicals: An Insight into their Potential Use in Cytokine Storm Situations.
Authors: Alarabei Abdusalam Abdullah , Abd Aziz Nur Aimi Liyana , AB Razak Nur Izah , Abas Razif , Bahari Hasnah , Abdullah Maizaton Atmadini , Hussain Mohd Khairi , Abdul Majid Amin Malik Shah , Basir Rusliza
Published: July 2023

Phytochemicals are compounds found in plants that possess a variety of bioactive properties, including antioxidant and immunomodulatory properties. Recent studies have highlighted the potential of phytochemicals in targeting specific signalling pathways involved in cytokine storm, a life-threatening clinical condition resulting from excessive immune cell activation and oversupply of proinflammatory cytokines. Several studies have documented the immunomodulatory effects of phytochemicals on immune function, including their ability to regulate essential cellular and molecular interactions of immune system cells. This makes them a promising alternative for cytokine storm management, especially when combined with existing chemotherapies. Furthermore, phytochemicals have been found to target multiple signalling pathways, including the TNF-α/NF-κB, IL-1/NF-κB, IFN-γ/JAK/STAT, and IL-6/JAK-STAT. These pathways play critical roles in the development and progression of cytokine storm, and targeting them with phytochemicals represents a promising strategy for controlling cytokine release and the subsequent inflammation. Studies have also investigated certain families of plant-related constituents and their potential immunomodulatory actions. In vivo and in vitro studies have reported the immunomodulatory effects of phytochemicals, which provide viable alternatives in the management of cytokine storm syndrome. The collective data from previous studies suggest that phytochemicals represent a potentially functional source of cytokine storm treatment and promote further exploration of these compounds as immunomodulatory agents for suppressing specific signalling cascade responses. Overall, the previous research findings support the use of phytochemicals as a complementary approach in managing cytokine storm and improving patient outcomes.
Low-affinity NMDA receptor antagonist hemantane in a topical formulation attenuates arthritis induced by Freund’s Complete Adjuvant in rats
Authors: Ivanova Elena , Matyushkin Alexander , Sorokina Alexandra , Alexeeva Svetlana , Kachalov Kirill , Miroshkina Irina , Voronina Tatyana , Durnev Andrey
Published: July 2023

Objective: N-methyl-D-aspartate (NMDA) receptors that are expressed by T-cells modulate T-cell proliferation, cytotoxicity and cell migration toward chemokines. Several studies have shown an anti-inflammatory effect of NMDA receptor antagonists. This study compares the effect of the noncompetitive low-affinity NMDA receptor antagonist N-(2-adamantyl)-hexamethyleneimine hydrochloride (hemantane) in a topical formulation (gel) with the cyclooxygenase (COX) inhibitor diclofenac in a topical formulation (gel) in rats with arthritis induced by Freund’s Complete Adjuvant (FCA). Methods: On day 14 after an FCA injection into the left hind paw, rats with contralateral hind paw edema were selected for further investigation (29/65). They were treated with 5% Hemantane gel or 1% Diclofenac gel applied locally to hind paws daily for 2 weeks starting 14 days after the FCA injection. Rats with arthritis were examined hind paw edema, hyperalgesia, and motor deficits; their body weight and hematological parameters were recorded. The rats were euthanized on day 28, followed by histological examination of the ankle joint (HE stain). Results: Rats with arthritis exhibited hind paw inflammation and hyperalgesia, motor deficits, changes of hematological parameters, reduced weight gain and spleen hypertrophy. Histological examination of the ankle joint revealed degenerative-dystrophic lesions of the cartilaginous tissue, proliferative inflammation of the synovium, edema and lymphocytic/macrophage infiltration of periarticular tissues. Hemantane gel reduced hind paw edema, pain, motor deficits and histological signs of inflammation; its effect was comparable to diclofenac gel. Conclusion: Hemantane gel alleviates FCA-induced arthritis in rats, and its effect is comparable to diclofenac gel.
The Simultaneous Effects of MIR-145-5p and Has-Let-7a-3p on Colorectal Tumorigenesis: in Vitro Evidence
Authors: Mozammel Nazila , Baghbani Elham , Amini Mohammad , Jodeiry Zaer Sheyda , Baghay Esfandyari Yalda , Tohidast Maryam , Hosseini Seyed Samad , Rahmani Seyed Ali , Mokhtarzadeh Ahad , Baradaran Behzad
Published: July 2023

Purpose: MicroRNAs (miRNAs) are a group of small regulatory non-coding RNAs which are dysregulated through tumor progression. let-7 and MIR-145 are both tumor suppressor microRNAs that are downregulated in a wide array of cancers, including colorectal cancer (CRC). Methods: This study aimed to investigate the effect of simultaneous replacement of these two tumor suppressor miRNAs on proliferation, apoptosis, and migration of CRC cells. HCT-116 with lower expression levels of hsa-let-7a-3p and MIR-145-5p was selected for functional investigations. The cells were cultured and transfected with hsa-let-7a and MIR-145 separately and in combination. Cell viability and apoptosis rates were assessed by MTT assay and flow cytometry, respectively. Cell cycle status was further evaluated using flow cytometry, and qRT-PCR was employed to evaluate gene expression. Results: The obtained results showed that exogenous overexpression of MIR-145 and hsa-let-7a in HCT-116 cells could cooperatively decrease CRC cell proliferation and induce sub-G1 cell cycle arrest. Moreover, hsa-let-7a and MIR-145 co-transfection significantly increased apoptosis induction compared to separate transfected cells and control through modulating the expression levels of apoptosis-related genes, including Bax, Bcl-2, P53, Caspase-3, Caspase-8, and Caspase-9. Furthermore, qRT-PCR results illustrated that hsa-let-7a and MIR-145 combination more effectively downregulated MMP-9 and MMP-2 expression, as the important modulators of metastasis, compared to the controls. Conclusion: Taken together, considering that exogenous overexpression of MIR-145 and hsa-let-7a showed cooperative anti-cancer effects on CRC cells, their combination may be considered as a novel therapeutic strategy for the treatment of CRC.
Chitosan/Hyaluronan and Alginate-nanohydroxyapatite Biphasic Scaffold as a Promising Matrix for Osteoarthritis Disorders
Authors: Banihashemian Abdolvahab , Zamanlui Benisi Soheila , Hosseinzadeh Simzar , Shojaei Shahrokh , Abbaszadeh Hojjat Allah
Published: July 2023

Purpose: Regenerative medicine offers new techniques for osteoarthritis disorders, especially while considering simultaneous chondral and subchondral regenerations. Methods: Chitosan and hyaluronan were chemically bound as the chondral phase and the osteogenic layer was prepared with alginate and nano-hydroxyapatite (nHAP). These scaffolds were fixed by fibrin glue as a biphasic scaffold and then examined. Results: Scanning electron microscopy (SEM) confirmed the porosity of 61.45 ± 4.51 and 44.145 ± 2.81 % for the subchondral and chondral layers, respectively. The composition analysis by energy dispersive X-ray (EDAX) indicated the various elements of both hydrogels. Also, their mechanical properties indicated that the highest modulus and resistance values corresponded to the biphasic hydrogel as 108.33 ± 5.56 and 721.135 ± 8.21 KPa, despite the same strain value as other groups. Their individual examinations demonstrated the proteoglycan synthesis of the chondral layer and also, the alkaline phosphatase (ALP) activity of the subchondral layer as 13.3 ± 2.2 ng. After 21 days, the cells showed a mineralized surface and a polygonal phenotype, confirming their commitment to bone and cartilage tissues, respectively. Immunostaining of collagen I and II represented greater extra cellular matrix (ECM) secretion in the biphasic composite group due to the paracrine effect of the two cell types on each other. Conclusion: For the first time, the ability of this biphasic scaffold to regenerate both tissue types was evaluated and the results showed satisfactory cellular commitment to bone and cartilage tissues. Thus, this scaffold can be considered a new strategy for the preparation of implants for osteoarthritis.
Cobalt/Bioglass Nanoparticles Enhanced Dermal Regeneration in a 3-Layered Electrospun Scaffold
Authors: Hemmati Dezaki Zahra , Parivar Kazem , Goodarzi Vahabodin , Nourani Mohamad Reza
Published: July 2023

Due to the multilayered structure of the skin tissue, the architecture of its engineered scaffolds needs to be improved. In the present study, 45s5 bioglass nanoparticles were selected to induce fibroblast proliferation and their protein secretion involved in wound healing, although cobalt ions were dopped to increase their potency. 3-layer scaffold was designed and fabricated via electrospinning method: polyurethane (PU) as outer layer, polycaprolactone (PCL) /collagen as middle layer and BGs nanoparticle/PCL/collagen as inner layer. Two three-layer scaffold with difference in inner layer fabricate and classified in two experimental groups. The scaffold groups were then examined in the following by scanning electron microscopy (SEM) and fourier transform infrared (FTIR) methods. Also, the mechanical assay showed the highest young modulus for the composite scaffold with the doped nanoparticles and the water contact angle of this scaffold after chemical crosslinking of collagen was reduced to 52.34 ± 7.7°. On the other hand, the weight loss of the corresponding scaffold was the highest value of 82.35 ± 4.3 % due to the alkaline effect of metal ions. Moreover, better cell expansion, greater cell confluence and a lower degree of toxicity were confirmed by using L-929 fibroblasts for the composite scaffold with the substituted nanoparticles. Also, the up-regulation of TGF β1 and VEGF introduced this composite scaffold as a better model for the fibroblasts commitment to a new skin tissue without scar. As a conclusion, the 3-layered scaffold which is loaded with cobalt ions-bonded bioglass nanoparticles, is a better substrate for the culture of the fibroblasts and dermal regeneration.
Penetration and durability of CPP-ACP paste and sodium fluoride varnish as desensitizing agents: An in vitro comparison
Authors: Golriz Naghmeh , Barekatain Mehrdad , Mirzakocheki Broujeni Parvin
Published: July 2023

Background. This study aimed to investigate and compare the penetration and durability of two dentin desensitizers, sodium fluoride varnish and casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) paste, using electron microscopy. Methods. The study was performed on 60 dentin specimens prepared from extracted human premolars. After applying 17% EDTA to remove the smear layer, the specimens were divided into two groups. MI Paste and Bi-fluoride varnish were applied to the specimens. Microscopic images of 20 samples were obtained immediately. Twenty other samples were accessed after 15 days, and the other 20 were accessed after 30 days of toothbrushing and thermal cycling. Both surface and longitudinal cross-sectional images (after sample fracture) were studied. Data were analyzed with two-way ANOVA and Mann-Whitney U test at a significance level of P<0.05. Results. The mean depth of material penetration was significantly time-dependent and fluctuated in both groups. There was a significant difference between the mean level of plugs between 0, 15, and 30 days (P<0.001). Penetration increased with time for the MI Paste group, while in the Bi-fluoride group, the increase was significant at 15 and 30 days than immediately after application. The mean thickness of the plugs was significantly different at the three time periods, and MI Paste showed a sudden decrease in plug thickness after 15 days. Conclusion. Immediately after application, Bi-fluoride occluded dentinal tubules more effectively, and its durability after abrasion and thermal fatigue were higher than MI Paste.
The comparison of the repair bond strength of the composite resin to direct and indirect composite restorations with different surface preparations
Authors: Bahadir Hasibe Sevilay , Polatoğlu Selin , Tuncer Duygu , Çelik Çiğdem
Published: July 2023

Background. Indirect restorations have been employed in restorative dentistry to solve some of the drawbacks of direct restorations. The aim of this study was to evaluate the effect of different modes of a universal adhesive resin on the repair capacity of two indirect resin composites and a direct resin composite. Methods. Indirect composite resins (Ceramage and Gradia Plus) and a direct composite resin (Filtek Z250) were prepared in a plastic mold with a height and diameter of 2-mm and 6-mm, respectively. Composite blocks were thermocycled (5000 cycles, 5°C-55°C). Then, according to their surface treatments, composite blocks were categorized into six-groups: Group 1: ER (etch&rinse), Group 2: SE (self-etch), Group 3: Bur+ER (bur+etch&rinse), Group 4: Bur+SE (bur+self-etch), Group 5: Bur+Silane+ER (bur+silane+etch&rinse), Group 6: Bur+Silane+SE (bur+silane+self-etch), respectively. After surface treatments and adhesive application for bonding with a direct resin composite, all groups were then thermocycled before performing shear-bond-strength-test. Failure modes were evaluated using a stereomicroscope. Data were analyzed by two-way-ANOVA and Bonferroni-test (P<0.05). Results. The highest bond-strength values were obtained for Bur+Silane+SE groups, while the lowest values were obtained for the Bur+Silane+ER groups for all materials. Statistically significant differences were observed between the Bur+Silane+ER group and ER, Bur+ER and Bur+Silane+SE groups in Gradia Plus (P<0.05). Conclusion. The self-etch-mode of the universal-adhesive and silane applications led to the increase in the repair-strength of the adhesive in the Filtek Z250 and Ceramage. The self-etch-mode of the universal-adhesive might be used to reduce adhesive-application-steps in the clinical repair procedures.
Assessment of the outcomes and stability after mandibular incisor extraction in orthodontic patients: A systematic review and meta-analysis
Authors: Gandhi Rasiga , Jnaneshwar Poornima , Venkatesan Keerthi , Devasahayam Davis , Rajaram Krishnaraj , Mohamed Azharudeen Rajia , Jothy Kavichithraa
Published: July 2023

Background. This study assessed the stability of the outcomes after mandibular incisor extraction (MIE) using intercanine width and peer assessment rating (PAR) scores in orthodontic patients. Methods. PubMed, Cochrane Library, Science Direct, Google Scholar, Ovid, and SciELO were systematically searched without restrictions until August 2022. A risk of bias assessment was performed using Newcastle-Ottawa Scale (NOS). The Grading of Recommendations, Assessment, Development, and Evaluation tool was used to assess the quality of evidence. Random effects meta-analysis was performed using RevMan software. Results. Seven retrospective studies met the inclusion criteria and were included. Meta-analysis identified a statistically significant reduction in intercanine width with MIE after the retention period. The mean difference in post-retention changes concerning intercanine width (MD=0.14, 95% CI: -2.17–1.89; P<0.00001) was significantly higher in premolar extraction (PE) compared to incisor extraction and significantly less in non-extraction compared to incisor extraction (MD=0.72, 95% CI: -0.59–2.03; P<0.00001). Improvements in PAR scores from the start of treatment to the retention period indicated a high outcome standard (>70%) with MIE treatment, with no significant difference in the reduction percentage compared to premolar and non-extraction groups. Conclusion. With the existing retrospective studies of limited evidence, treatment outcomes with MIE were found to show good improvements in PAR scores. Some reduction in the intercanine width was evident after the retention period, which was observed even with the other two treatment modalities that were compared. Hence, with careful evaluation, MIE could be considered a valid treatment option.
Whether the Legal Fiction of Public Officials can determine the “officialness” of documents
Authors:   LAW RESEARCH INSTITUTE CHUNGBUK NATIONAL UNIVERSITY, Lee Seungjun
Published: July 2023

Recently, the Supreme Court ruled that a document issued by the governor of the Financial Supervisory Service(FSS) is considered a public document according to Articles 29 and 69(1) of the Act on the Establishment of the Financial Services Commission. Article 69 of this Act states that individuals who are not public officials are treated as public officials when it comes to applying penalties under the Criminal Code or other laws. The governor of the FSS is classified as a public official by presidential decree, thus falling under this Legal Fiction of Public Officials. Based on this regulatory framework, the Supreme Court concluded that a document issued by the governor of the FSS should be considered an official document. This interpretation is justified as it is appropriate to interpret the governor of the FSS and other employees as public officials for the purpose of imposing equal responsibilities and providing them with the same protection as public officials. However, this interpretation does not justify treating crimes against non-government employees as crimes against government employees, as it broadens the scope of the current penalty system and serves as a compensatory mechanism for excessive punishment. According to this interpretation, there are always errors of the the actor. In this case, it would be appropriate to penalize the actor for falsifying a document under Article 15(1) of the Criminal Code. Despite the lack of merit in this interpretation, it is difficult to agree that interpreting, when they provide penalties for non-public officials based on the 'type of criminal law fiction,' exceeds the limits of interpretation. The role of the judiciary is to declare what the law is, and if bad legislation exists, it is the responsibility of the legislature to correct it through new legislation. Expanding the scope of punishment for bad legislation through an interpretation that goes beyond the literal meaning of the text.
A Study on the Unexplained Wealth Order for the Return of Crime Proceeds under United Kingdom Law
Authors:   LAW RESEARCH INSTITUTE CHUNGBUK NATIONAL UNIVERSITY, Lee Young Don
Published: July 2023

Among the motives for crime, economic crimes for economic benefit account for the majority. Therefore, in order to secure the deterrence of crime and realize the justice of criminal justice, it is urgently necessary to recover criminal proceeds. Failure to properly recover criminal proceeds can cause a relative sense of deprivation to the general public who comply with the law, thereby diluting the sense of compliance. In this study, the background, related regulations, and application cases of the Unexplained Wealth Order introduced under the Criminal Finance Act 2017 were reviewed to systematically support the proof of criminal proceeds in the UK. UWO is an order that requires law enforcement agencies to provide specific information, including “explain to the defendant how the property was acquired.” If the Defendant does not comply with the UWO, the relevant property may be subject to civil recovery. UWO is not an independent civil confiscation system, but it is meaningful in terms of a system that facilitates civil recovery by changing the burden of proof. Currently, our individual laws have a pre-indictment confiscation preservation order system to facilitate the recovery of criminal proceeds for suspects. If the confiscation preservation order system is actively used before prosecution, the possibility of introducing the UWO system will not be high. However, for crimes that require the recovery of criminal proceeds in the future, such as money laundering and organized crimes, there is room to carefully review whether the principle of presumption of innocence is violated and partially consider the introduction of the UWO system. Therefore, in order to introduce such a system, first of all, the disclosure of statistics on the recovery of criminal proceeds and the discussion on the problem of the recovery of criminal proceeds under our law must be activated.
Suggestions for Preventing Abuse of Persons with Disabilities: Focusing on the revision of ｢Act on Welfare of Persons with Disabilties｣ and comparative legal review of Japanʼs ｢Act on Prevention of Abuse of Persons with Disabilities｣
Authors:   LAW RESEARCH INSTITUTE CHUNGBUK NATIONAL UNIVERSITY, Kim Zaehee
Published: July 2023

The National Assembly is constantly discussing the enactment of the “Act on Special Cases on the Punishment of Abuse of Persons with Disabilities” for crimes of abuse of persons with disabilities. The enactment's arguments primarily call for zero tolerance and harsh penalties. However, it raises questions about the effectiveness of responding to the crime of abuse of the disabled only with aggravated punishment. In order to respond to abuse of the disabled, various cause analysis and approaches are needed. In particular, in the case of abuse by guardians of the disabled, if the guardian's economic and emotional burden leads to abuse, it will be more effective to prevent abuse of the disabled through education and support rather than severe punishment for the abuser. Then, in order to prevent abuse of the disabled, we looked at whether the current Welfare of the Disabled Act is meaningless in responding to abuse of the disabled. In addition, Japan's “Act on Prevention of Abuse of Persons with Disabilities” was comparatively reviewed. It was intended to effectively prevent abuse of the disabled and to propose practical countermeasures.
Revision of Civil Procedure Act of Japan in 2022: From the Perspective on the Implications of Civil Electronic Litigation
Authors:   LAW RESEARCH INSTITUTE CHUNGBUK NATIONAL UNIVERSITY, Cho Soo Hye
Published: July 2023

Electronic litigation ensures the accessibility of trial proceedings and court records to the general public by utilizing electronic documents and an electronic case management system. Information Technology (IT) enables litigation to be conducted expeditiously. In this regard, electronic litigation not only facilitates fair and efficient trials but also enhances public trust in the judicial system. However, the implementation of electronic litigation requires the legislation for electronic litigation and the development of systems to facilitate its operation. Initially hesitating the adoption of electronic litigation, Japan fully embraced it by revising the Civil Procedure Act of Japan in 2022. This revision encompasses a broad range of modifications to the civil litigation system, including not only the digitalization of civil litigation, but also the introduction of expedited procedures, the implementation of a protective measure for party identification, and the establishment of procedures for the investigation of electronic evidence. The primary objective behind Japan's reform of civil litigation adopting electornic litigation is to enhance procedural efficiency and effectiveness, improve litigant accessibility, and ultimately uphold the principles of fairness in trials, thereby elevating the overall quality of the judicial process. This paper focuses on three key aspects: 1) online filing and service, 2) electronic courtroom, and 3) electronic case management. By conducting a comparative study on the provisions of electronic litigation between Japan and Korea, it can be expected to introduce implications with regard to electronic litigation in Korea.
An Empirical Study of the Optimal Patent Term
Authors:   LAW RESEARCH INSTITUTE CHUNGBUK NATIONAL UNIVERSITY, Lee Sang Mi
Published: July 2023

Theoretically, the ideal term of a patent is to set up to expire when the social costs outweigh the benefits. However, given the decline in returns from patents over time and the discount rate of the annual patent value, a period of 20 years is actually quite a long time for the average inventor. In particular, considering that the product cycle in the high-tech industry is very short, it is doubtful whether the current long and uniform duration adequately reflects society's expectations, or whether the costs for access or transaction are excessively imposed. Many studies on finding the optimal patent term have discussed it as an economic point of view. Some have proposed an optimal patent policy through a combination of patent length and scope, while others have suggested adjusting the strength of patent protection through a single adjustment of the length. This paper attempts to approach this problem based on the latter. And when setting the optimal patent term, classification by industry(or by technical characteristics) should be premised. This is because, in fact, the cost of developing an invention and its benefits in terms of social welfare vary from field to field. This paper emphasizes the need to shorten the term of patents and grant differentiated terms for each category of patents, and proposes to realize these policies.
Analysis of Opportunities and Prospects of Lipofilling Method in Patients with Atrophic Skin Scarring: A Literature Review
Authors: Галицкая Ю.И. , Дундаров З.А. , Евсеенко Д.А. , Адамович Д.М.
Published: July 2023

В статье освещены современные научные данные, посвященные анализу методики трансплантации аутологичной жировой ткани. Освещена морфологическая и биохимическая характеристика патологически измененной ткани до выполнения оперативного вмешательства с целью контурной коррекции рубцовой деформации. Собраны современные научные классификации рубцовых изменений кожных покровов. Проведен анализ показаний к применению метода липофилинга. Указаны перспективы использования комбинации лекарственных средств, характеризующихся антиоксидантной активностью. Обозначена возможность биохимической и морфологической оценки локального состояния антиоксидантного статуса реципиентной зоны после классической контурной коррекции в комбинации с использованием антиоксидантов с целью улучшения результатов реабилитации пациентов с рубцовыми деформациями атрофического характера различной этиологии.

The article covers modern scientific data devoted to the analysis of the technique of autologous adipose tissue transplantation. Morphological and biochemical characteristics of the pathologically changed tissue before surgical intervention for scar deformity contouring are highlighted. Modern scientific classifications of cutaneous scar changes have been collected. The analysis of indications for lipofilling method application was carried out. Prospects of using combinations of drugs characterized by antioxidant activity are indicated. The possibility of biochemical and morphological evaluation of local state of antioxidant status of the recipient area after classical contour correction in combination with antioxidants to improve rehabilitation results of patients with atrophic scar deformities of various etiologies is outlined.
Pathophysiological Aspects of Free Radical Mechanisms in Hepatic Tissue in Cirrhosis: Correction Strategies. A Literature Review
Authors: Евсеенко Д.А. , Дундаров З.А. , Чуешова Н.В. , Надыров Э.А. , Щемелев В.М.
Published: July 2023

В настоящее время проблема коррекции нарушений антиоксидантного статуса остается не до конца решенной, что позволяет осуществлять поиск новых и эффективных методов современной диагностики и лечения пациентов с циррозом печени. В данном аналитическом обзоре литературы рассматриваются ключевые патофизиологические аспекты свободнорадикальных механизмов в печени при циррозе. Кратко описана многостадийность реакций свободнорадикального окисления в пораженной циррозом печени, что закономерно требует обоснованного с патофизиологической точки зрения обрыва их цепных механизмов. Обозначена возможность изучения локального состояния антиоксидантного статуса биоптата патологически измененной печеночной ткани. Обозначены перспективные стратегии коррекции нарушений свободнорадикального окисления путем введения лекарственных средств, характеризующихся антиоксидантной активностью, в портальную и кубитальные вены с целью локальной коррекции нарушений антиоксидантного статуса в печеночной ткани.

Nowadays, the issue of antioxidant status abnormalities correction remains not fully resolved, allowing searching for new and effective methods of modern diagnostics and treatment of patients with liver cirrhosis. This analytical literature review considers key pathophysiological aspects of free-radical mechanisms in the liver in cirrhosis. Multistage reactions of free-radical oxidation in the liver affected by cirrhosis are briefly described, thus naturally requiring their chain mechanisms to be substantiated under pathophysiological point of view. The possibility of studying the local state of antioxidant status of a biopsy sample obtained from pathologically altered liver tissue is outlined. Promising strategies for correcting of free-radical oxidation disorders by introducing drugs characterized by antioxidant activity into portal and cubital veins for local correction of antioxidant status disorders in hepatic tissue are outlined.
A Review of the European Society of Anesthesiology and Intensive Care Guidelines for Perioperative Management of Neuromuscular Blockade
Authors: Теренин М.А. , Грачев С.С. , Титова А.Д. , Миронович Д.А. , Петух Е.А. , Гордейко В.А. , Ермоленко У.А.
Published: July 2023

В начале 2023 г. экспертами Европейского общества анестезиологии и интенсивной терапии было опубликовано первое руководство по периоперационному ведению нейромышечной блокады, основанное на обзоре литературы до 31 декабря 2021 г. Данный документ включает в себя 8 рекомендаций, направленных на улучшение качества оказания медицинской помощи врачами-анестезиологами и обеспечение безопасности пациентов в периоперационном периоде. Чтобы облегчить их внедрение в клиническую практику, руководство было намеренно ограничено 3 клинически значимыми вопросами: значением миорелаксантов для интубации трахеи, вкладом миорелаксантов в улучшение хирургических условий ведения операций и значением нейромышечного мониторинга и фармакологической реверсии в уменьшении остаточного нейромышечного блока и послеоперационных миорелаксантассоциированных осложнений дыхательной системы.

In early 2023, experts of the European Society of Anesthesiology and Intensive Care published the first guidelines for the perioperative management of neuromuscular blockade, based on the literature review through December 31, 2021. This document includes 8 recommendations aimed at improving the quality of care provided by anesthesiologists and ensuring patient safety in the perioperative period. To facilitate their implementation in clinical practice, the guidelines were deliberately limited to three clinically relevant issues: the value of muscle relaxants for tracheal intubation, the contribution of muscle relaxants to the improvement of surgical conditions during a surgery, and the value of neuromuscular monitoring and pharmacological reversion to reduce residual neuromuscular block and postoperative muscle relaxant-associated respiratory complications.
TAFAKKUR SEBAGAI KONSEPSI MENUJU KEABADIAN MANUSIA MODERN
Authors: Hasanah Uswatun , Hartono Hartono
Published: July 2023

The purpose of this study is to understand human identity as a servant in an era where technological sophistication is rapidly increasing which causes humans to be preoccupied with the virtual world. The millennial generation who spends their time chatting, Facebook, Whatsapp, Instagram, YouTube and so on, forgets about their future. This research uses the library research method (library), with a descriptive-analytical method through the religious theology approach. As stated in Surah Ali Imran verses 190-191, in this surah there is also an explanation of ethics for people who meditate, namely by confronting Allah by purifying Him from the futility of creating something. The results obtained in this study can determine the concept of tafakkur, namely faith, ulul albab, dhikr, meditating which then ends with prayer. In this study, we also know the correlation of contemplation to the prevention of environmental damage to devotion in the goodness of the world to the hereafter. If a person or group from the community always applies the content contained in Surah Ali Imran verses 190-191, it can reduce activities that are not useful, useless and will automatically increase the quality of one's faith. This faith will give birth to humans who have good morals and mentality, so that they can overcome environmental damage and eternal goodness throughout time.
PROBLEMATIKA IHDAD DAN DINAMIKA PEMIKIRAN HUKUM ISLAM DI INDONESIA
Authors: Abdi Efan Chairul , Zaiyadi Ahmad
Published: July 2023

On the one hand, ihdad demands that it be understood more textually on the mainstream, while on the social demands it demands equality, demands for human rights and so on. Especially in Indonesia, the view of ihdad between traditional and liberal in responding to the issue of reforming Islamic law in Indonesia occurs dialectically in that discourse. Therefore, it is important to conduct further research on Ihdad focused on both views, intending to analyze the opinions of Liberalism and Traditionalism against Ihdad and its relevance to Islamic law reform in Indonesia by using the method of literature studies based on a comparative approach. This study concludes that the liberalist view of ihdad looks at all aspects, including looking at the context of Arab civilization at that time, then compared it with the context of the society in different places and times. Therefore they put Ihdad's problem in a condition that would happen to humans even without any conditioning demands from the legal aspect. Meanwhile, traditional figures formulate the concept of ihdad in the same way as the opinion of the priests of the four madhhabs or classical fiqh, namely placing the problem of Ihdad in mandatory law and determining the conditions in ihdad. By looking at the characteristics of the two ideas above, what is relevant is the model of moderate thought between the two which is more directed at developing the subject of Ihdad law which is not only limited to the wife but also to the husband after first determining the reason for Ihdad, namely to mourn and avoid slander. Then, the provision of time in performing Ihdad must be adjusted to the situation
EPISTEMOLOGI KONSTRUKSIONISME SEBAGAI DASAR PENELITIAN SOSIAL
Authors: Kamaludin Kamaludin , Masruchan Masruchan
Published: July 2023

Hadith research is research that has a wide range of objects. In addition to focusing on internal aspects related to the text, such as research on matan and narrators, hadith research also includes matters relating to the content of hadith on the dynamic human life with the struggles of other human implementations. In this case, further hadith research reaches aspects related to social research in general which has an epistemology of the basics of acquiring a distinctive knowledge, one of which is the epistemology of constructionism.

This research uses the literature study method which aims to describe how the constructivism epistemology in social research is. The result of this research is that the epistemology of constructionism is a critique or opponent of the positivism paradigm, which is a criticism or opponent of the positivism paradigm which has a transactional relationship pattern (responsible) for the object under study and participatory dialectics (going directly into the reality of society).
ANALISIS TAFSIR, TA’WIL DAN HERMENEUTIKA DALAM KEBERLANJUTAN SAINS
Authors: Hartono Hartono
Published: July 2023

Tujuan penelitian ini untuk memahami manfaat dan urgensi penafisiran kitab suci sebagai solusi dalam kehidupan. Metode penelitian menggunakan penelitian pustaka dan fakta lapangan selama beberapa waktu secara hati-hati dan teliti. Manfaat penelitian ini juga diharapkan memberi pemahaman tentang pentingnya ilmu tafsir, dalam artikel ini juga disajikan perbedaan dan persamaan antara tafsir, ta’wil dan hermeneutika dalam keberlanjutan ilmu pengetahuan. Memahami penjelasan dan menyingkap isi kandungan Al-Qur’an atau berusaha menampakkan segala hal yang masih tersembunyi dalam teks kitab suci hingga kitab suci benar-benar menjadi solusi dalam kehidupan.
How does Social Media Platforms of Facebook and Twitter used during COVID-19 Vaccination Campaign? A Study in West Sumatera
Authors: Azmi Novia Amirah , Weriframayeni Annisa , Elysia Eda , Fathani Aqil Teguh , Agustiyara Agustiyara
Published: July 2023

This study aims to see the effectiveness social media platforms campaigning COVID-19 vaccination program in West Sumatra. This result provides new suggestions to interest actors to emphasize the dissemination of information through one of their social media. Measuring the effectiveness of communication is carried out by the recipient of the message, the source of the message, and the content of the message. Mixed methods research with the help of NVIVO 12+ analysis was conducted to give actual results. Sources of data obtained from community activities using Facebook and Twitter. The study's results showed a significant difference in the age of users on Facebook and Twitter; Facebook users were dominated by users less than 18 years and more than 50 years which affected the message delivery and message content for the vaccine campaign. Information changes often occur on Facebook because many users change information and make requests not to vaccinate. This call was also followed by bad news which assumed that vaccination would have a bad impact in the long term. Twitter users are more open and understand the information that circulates on social media, thus there are less opportunities to change information and spread falsehoods. Twitter users' favorable attitudes and actions when communicating on social media demonstrate that information distribution is more about a sense of security and comfort. The two platforms have been the most popular tools for public evaluation since individuals use social media more than they do traditional kinds of media.
The Effectiveness of Digitizing Tax Administration to Reduce the Compliance Cost of Taxpayers of Micro, Small, and Medium Enterprises (MSMEs)
Authors: Murnidayanti Scheilla Aprilia , Putranti Titi Muswati
Published: July 2023

MSMEs are a growing and vital sector for the country's economy. However, until now, MSMEs taxpayer compliance is still low. DGT then digitized tax administration with the aim of reducing taxpayer compliance costs for MSMEs taxpayers. This paper analyzes the effectiveness of digitizing tax administration in reducing MSMEs taxpayer compliance costs and DGT's steps to reduce MSMEs taxpayer compliance costs. The method used in this study is qualitative with a literature study approach. Secondary data was obtained from various library sources, including books, encyclopedias, dictionaries, journals, documents, magazines, etc. The study results show that the digitization of tax administration in Indonesia has not reduced the cost of taxpayer compliance for MSMEs taxpayers. In addition, other factors that can influence MSMEs taxpayer compliance include knowledge, mediation, perceptions of fairness, and so on. DGT has simplified the tax system and digitized tax administration to reduce tax compliance costs. The originality of this research is in analyzing the relationship between the digitization of tax administration and tax compliance costs for MSMEs.
Policy Development for handling COVID-19 from the Perspective of a Policy Narrative Framework
Authors: Khotami Khotami , Gesmi Irwan , Yogia Moris Adidi , Amri Pahmi , Sasmi Dini Tiara
Published: July 2023

The spread of the covid-19 outbreak entered Indonesia since 2020. COVID-19 has had an impact on society and government, so that the government, especially the city of Pekanbaru, has carried out various policy strategies to carry out countermeasures in the spread of Covid-19, but the number of spread of covid-19 still has not decreased significantly. This research aims to develop a policy narrative framework that functions in advocating for the media as well as providing influence in the decision/policy making process. This research used qualitative analysis using the Policy Narrative Framework (NPF) approach. This study found that narratives by government actors and the general public in online news media had an influence on the policy of handling Covid-19. The policy narrative framework approach (NPF) contributes to this research such as elements of the storyline of policy development and the role of actors who are directly involved in policy. The implementation of the COVID-19 vaccine program through social media support can be seen from the existence of four indicators, namely Communication, Resources, Disposition, and Bureaucratic Structure and looking at the message sender’s, recipient and quality of message via social media.
Pengembangan Sistem Informasi Pendataan Dan Peminjaman Sarana Prasarana Pada Sma Ibrahimy Sukorejo Berbasis Web
Authors: Arifurrohman Moh Rivki , Sunardi Sunardi , Lidimilah Lukman Fakih , A. Hamdani
Published: July 2023

SMA Ibrahimy Sukorejo merupakan sekolah swasta yang berada dalam tetorial Yayasan Pondok Pesantren terbesar yang berada di Timur Pulau Jawa Yaitu Pondok Pesantren Salafiyah Syafi'iyah Sukorejo berdiri Tepat pada tanggal 23 April 1981. Di sekolah tersebut dalam mengelola data dan peminjaman sarana prasarana masih dengan cara manual yaitu dengan pencatatan di buku. Pengelolaan Sarana  Prasarana dan Peminjaman dengan cara seperti ini menyebabkan kurang maksimalnya dalam pengelolaan. Oleh karna itu, Sarana Prasarana yang berpindah tempat maupun barang yang di pinjam sulit di ketahui keberadaannya. Dengan Sistem Informasi Berbasis website dengan metode waterfall, karena metode ini tahapan dan juga langkah demilangkah yang dilalui harus diselesaikan satu per satu (tidak dapat meloncat ke tahap berikutnya)dan berjalan secara berurutan, oleh karena itu di sebut waterfall (Air Terjun), seperti layaknya sebuah air terjun. untuk mempermudah dalam pengumpulan data maka digunakan metode observasi, wawancara, dan studi pustaka. Sistem Informasi berbasis web ini di implementasikan dengan bahasa pemerograman PHP, dan basis data MySQL sebagai media penyimpanan data. Dari Penelitian ini telah menghasilkan Sistem Informasi Pendataan dan Peminjaman  Sarana Prasarana pada SMA Ibrahimy Sukorejo berbasis web.
IMPLEMENTASI DATA MINING C4.5, LINEAR REGRESI DAN KMEANS DENGAN MENGGUNAKAN FRAMEWORK DJANGO PYTHON
Authors: Faid Mochammad , Supri Ahmad , Sukron Moh
Published: July 2023

Penggunaan data dalam pengambilan keputusan bisnis telah berkembang menjadi kunci sukses di banyak bisnis di era digital yang berkembang. Data mining dapat memberi kan pemahaman yang menyeluruh tentang data dan mendorong pengambilan keputusan yang lebih bijak dengan memeriksa pola-pola yang tersembunyi dan menemukan hubungan yang relevan, namun bagaimana cara menimplementasikan sebuah algoritma data mining kedalam sebuah website diperlukan 2 keahlian dasar yaitu keahlian webdeveloper dan keahlian dalam sebuah datascient, Pada penelitian ini akan membahas bagaimana mengabung dua keahlian tersebut menjadi satu yaitu Webdeveloper dan datascient dengan menggunakan 3 algoritma klasifikasi, regresi dan algoritma cluster
Klasifikasi Kanker Payudara Menggunakan Algoritma SVM dengan Kernel RBF, Linier, dan Sigmoid
Authors: Abdurrahman Ginanjar
Published: July 2023

Breast cancer ranks first in both the gender category and the death rate. Late treatment is often found in cases of breast cancer which causes an increase in the risk factors for this cancer. For this reason, early detection of breast cancer is needed, so that treatment can be done in a timely manner, so that the death rate due to breast cancer can be reduced. For this reason, this article offers early detection of breast cancer using classification. The dataset in this study used the Wisconsin breast cancer dataset taken from Kaggle. Initially the dataset has a missing value, besides that the categorical data is not yet in numerical form, so it is necessary to do preprocessing with the missing value imputing technique and encoding to convert categorical data into numeric data. The dataset is divided into two proportions, namely 80% as training data and 20% as testing data. In the classification process, datasets that have been preprocessed are classified using SVM with three different kernels, namely the linear kernel, the RBF kernel, and the Sigmoid kernel. Based on the research results that have been obtained, the linear kernel shows the best classification results when applied to the SVM classification, namely with an accuracy value of up to 99%, followed by RBF kernel performance with an accuracy rate of 92%, and finally the sigmoid kernel with an accuracy value of 41%
SISTEM INFORMASI PENGOLAHAN DATA PERTANIAN BERBASIS WEB DI DESA KARANG DUREN
Authors: Resti Sutianingtyas  , Guruh Wijaya  , Rahman Miftahur
Published: July 2023

Sektor pertanian merupakan salah satu sektor lapangan pekerjaan bagi sebagian besar penduduk desa Karang Duren. Secara umum pengelolaan data proses pertanian pada tahap tanam dan panen belum menerapkan teknologi informasi, sehingga terdapat beberapa kelemahan seperti pengelolaan data yang kurang efisien dan efektif. Aplikasi pengelolaan data proses pertanian merupakan aplikasi yang dirancang untuk tahap perlindungan dan pemanenan. Dengan aplikasi ini dapat mengatur jadwal tanam, pemupukan, mengatur obat, dan hama, serta panen. Aplikasi ini dibuat dengan menggunakan langkah-langkah metode rekayasa perangkat lunak model waterfall . Untuk memastikan penyesuaian aplikasi ini dilakukan pengujian menggunakan black box testing. Aplikasi ini akan membantu petani dengan perencanaan, pemupukan, pengelolaan pestisida dan panen. Dengan perencanaan ini, setiap kegiatan dapat dipantau dengan rencana yang telah disusun untuk meminimalkan penyimpangan yang terjadi.