bluuebunny/crossref_metadata_2025 huggingface dataset:
Destabilization of Atherosclerotic Plaque by Bilirubin Deficiency
Authors: Chen Weiyu , Tumanov Sergey , Stanley Christopher P. , Kong Stephanie M.Y. , Nadel James , Vigder Niv , Newington Darren L. , Wang Xiao Suo , Dunn Louise L. , Stocker Roland
Published: March 2023

Background:

The rupture of atherosclerotic plaque contributes significantly to cardiovascular disease. Plasma concentrations of bilirubin—a byproduct of heme catabolism—inversely associate with risk of cardiovascular disease, although the link between bilirubin and atherosclerosis remains unclear.

Methods:

To assess the role of bilirubin in atherosclerotic plaque stability, we crossed
Bvra
−/−
with
Apoe
−/−
mice and used the tandem stenosis model of plaque instability. Human coronary arteries were obtained from heart transplant recipients. Analysis of bile pigments, heme metabolism, and proteomics were performed by liquid chromatography tandem mass spectrometry. MPO (myeloperoxidase) activity was determined by in vivo molecular magnetic resonance imaging, liquid chromatography tandem mass spectrometry analysis, and immunohistochemical determination of chlorotyrosine. Systemic oxidative stress was evaluated by plasma concentrations of lipid hydroperoxides and the redox status of circulating Prx2 (peroxiredoxin 2), whereas arterial function was assessed by wire myography. Atherosclerosis and arterial remodeling were quantified by morphometry and plaque stability by fibrous cap thickness, lipid accumulation, infiltration of inflammatory cells, and the presence of intraplaque hemorrhage.

Results:

Compared with

Bvra
+/+
Apoe
−/−

tandem stenosis littermates,
Bvra
−/−
Apoe
−/−
tandem stenosis mice were deficient in bilirubin, showed signs of increased systemic oxidative stress, endothelial dysfunction, as well as hyperlipidemia, and had a higher atherosclerotic plaque burden. Heme metabolism was increased in unstable compared with stable plaque of both

Bvra
+/+
Apoe
−/−

and
Bvra
−/−
Apoe
−/−
tandem stenosis mice and in human coronary plaques. In mice,
Bvra
deletion selectively destabilized unstable plaque, characterized by positive arterial remodeling and increased cap thinning, intraplaque hemorrhage, infiltration of neutrophils, and MPO activity. Proteomic analysis confirmed
Bvra
deletion enhanced extracellular matrix degradation, recruitment and activation of neutrophils, and associated oxidative stress in unstable plaque.

Conclusions:

Bilirubin deficiency, resulting from global
Bvra
deletion, generates a proatherogenic phenotype and selectively enhances neutrophil-mediated inflammation and destabilization of unstable plaque, thereby providing a link between bilirubin and cardiovascular disease risk.
Optogenetic Spreading Depolarizations Do Not Worsen Acute Ischemic Stroke Outcome
Authors: Sugimoto Kazutaka , Yang Joanna , Fischer Paul , Takizawa Tsubasa , Mulder Inge A. , Qin Tao , Erdogan Taylan D. , Yaseen Mohammad A. , Sakadžić Sava , Chung David Y. , Ayata Cenk
Published: March 2023

Background:

Spreading depolarizations (SDs) are believed to contribute to injury progression and worsen outcomes in focal cerebral ischemia because exogenously induced SDs have been associated with enlarged infarct volumes. However, previous studies used highly invasive methods to trigger SDs that can directly cause tissue injury (eg, topical KCl) and confound the interpretation. Here, we tested whether SDs indeed enlarge infarcts when induced via a novel, noninjurious method using optogenetics.

Methods:

Using transgenic mice expressing channelrhodopsin-2 in neurons (Thy1-ChR2-YFP), we induced 8 optogenetic SDs to trigger SDs noninvasively at a remote cortical location in a noninjurious manner during 1-hour distal microvascular clip or proximal an endovascular filament occlusion of the middle cerebral artery. Laser speckle imaging was used to monitor cerebral blood flow. Infarct volumes were then quantified at 24 or 48 hours.

Results:

Infarct volumes in the optogenetic SD arm did not differ from the control arm in either distal or proximal middle cerebral artery occlusion, despite a 6-fold and 4-fold higher number of SDs, respectively. Identical optogenetic illumination in wild-type mice did not affect the infarct volume. Full-field laser speckle imaging showed that optogenetic stimulation did not affect the perfusion in the peri-infarct cortex.

Conclusions:

Altogether, these data show that SDs induced noninvasively using optogenetics do not worsen tissue outcomes. Our findings compel a careful reexamination of the notion that SDs are causally linked to infarct expansion.
Comparing the Dominance of Color and Form Information across the Human Ventral Visual Pathway and Convolutional Neural Networks
Authors: Taylor JohnMark , Xu Yaoda
Published: March 2023

Color and form information can be decoded in every region of the human ventral visual hierarchy, and at every layer of many convolutional neural networks (CNNs) trained to recognize objects, but how does the coding strength of these features vary over processing? Here, we characterize for these features both their absolute coding strength—how strongly each feature is represented independent of the other feature—and their relative coding strength—how strongly each feature is encoded relative to the other, which could constrain how well a feature can be read out by downstream regions across variation in the other feature. To quantify relative coding strength, we define a measure called the form dominance index that compares the relative influence of color and form on the representational geometry at each processing stage. We analyze brain and CNN responses to stimuli varying based on color and either a simple form feature, orientation, or a more complex form feature, curvature. We find that while the brain and CNNs largely differ in how the absolute coding strength of color and form vary over processing, comparing them in terms of their relative emphasis of these features reveals a striking similarity: For both the brain and for CNNs trained for object recognition (but not for untrained CNNs), orientation information is increasingly de-emphasized, and curvature information is increasingly emphasized, relative to color information over processing, with corresponding processing stages showing largely similar values of the form dominance index.
Access to Immediately Available Balanced Blood Products in a Rural State’s Trauma System
Authors: Smedley W. Andrew , Mabry Charles D. , Collins Terry , Tabor Jeff , Bowman Stephen , Porter Austin , Young Sean , Klutts Garret , Deloach Joseph , Bhavaraju Avi , Maxson Todd , Robertson Ronald D. , Holcomb John B. , Kalkwarf Kyle J.
Published: March 2023

Introduction

The Arkansas Trauma System was established by law more than a dozen years ago, and all participating trauma centers are required to maintain red blood cells. Since then, there has been a paradigm shift in resuscitating exsanguinating trauma patients. Damage Control Resuscitation with balanced blood products (or whole blood) and minimal crystalloid is now the standard of care. This project aimed to determine access to balanced blood products in our state’s Trauma System (TS).

Methods

A survey of all trauma centers in the Arkansas TS was conducted, and geospatial analysis was performed. Immediately Available Balanced Blood (IABB) was defined as at least 2 units (U) of thawed plasma (TP) or never frozen plasma (NFP), 4 units of red blood cells (RBCs), 2 units of fresh frozen plasma (FFP), and 1 unit of platelets or 2 units of whole blood (WB).

Results

All 64 trauma centers in the state TS completed the survey. All level I, II, and III Trauma Centers (TCs) maintain RBC, plasma, and platelets, but only half of the level II and 16% of the level III TCs have thawed or never frozen plasma. A third of level IV TCs maintain only RBCs, while only 1 had platelets, and none had thawed plasma. 85% of people in our state are within 30 min of RBCs, almost two-thirds are within 30 min of plasma (TP, NFP, or FFP) and platelets, while only a third are within 30 min of IABB. More than 90% are within an hour of plasma and platelets, while only 60% are within that time from an IABB. The median drive times for Arkansas from RBC, plasma (TP, NFP, or FFP), platelets, and an immediately available and balanced blood bank are 19, 21, 32, and 59 minutes, respectively. A lack of thawed or non-frozen plasma and platelets are the most common limitations of IABB. One level III TC in the state maintains WB, which would alleviate the limited access to IABB.

Conclusion

Only 16% of the trauma centers in Arkansas can provide IABB, and only 61% of the population can reach IABB within 60 minutes. Opportunities exist to reduce the time to balanced blood products by selectively distributing WB, TP, or NFP to hospitals in our state trauma system.
Assessing the Need for Transfer to a Trauma Center for Isolated Craniofacial Injury in a Rural State
Authors: Ciraulo Luciano A. , Connolly Katharine A. , Falank Carolyne R. , Ciraulo David L.
Published: March 2023

Management of craniofacial injuries typically defaults to plastic, ophthalmology, and oral maxillofacial surgeons which can challenge these surgical subspecialists’ capacity to care for both trauma victims and non-trauma patients. Evaluating the need to transfer patients to a higher level of trauma care for isolated craniofacial injuries warrants investigation. Our 5-year retrospective study measured the frequency of craniofacial injuries and subsequent surgical interventions in elderly trauma patients’ ≥65 years old. Eighty-one percent of patients consulted with plastic surgeons and 28% with ophthalmology. Twenty percent had craniofacial surgery with the majority of surgical interventions were in soft tissue (97%), mandible (48%), and Le Fort III (29%) injuries. A patient’s ISS, GCS, head and face AIS, and presents of spinal or brain injury had no statistically significant impact on injury repair. Elderly patients with isolated craniofacial trauma may be better served by pretransfer consultation with a surgical subspecialist to determine the necessity.
Rib Plating Outcomes in Elderly Trauma Patients with Multiple Rib Fractures: A Community Hospital Experience
Authors: Wasfie Tarik , Sowa Matthew , White Hutton , Nesheiwat OMS-IV Sara N. , Hille Jennifer , Hella Jennifer , Barber Kimberly , Shapiro Brian
Published: March 2023

Rib plating has been shown to be beneficial among certain populations, such as patients with flail chest and failure to wean from the ventilator in patients without primary pulmonary pathology. Surgical intervention has been shown to decrease ventilatory requirements, decrease pain management modalities, and lower costs. A retrospective data analysis was done to determine the efficacy of rib plating in elderly trauma patients with rib fractures on a total of 244 patients, 63% male and 37% female, mean age is 64 ± 18.5 years, 76% had an associated comorbid condition, such as Diabetes Mellitus (DM), Chronic Obstructive Pulmonary Disease (COPD), Coronary Artery Disease (CAD), Chronic Kidney Disease (CKD), or any combination, with 111 (46%) on anticoagulant therapy. 95% patients presented to the emergency department (ED) with Mild GCS range (13-15). Moderate GCS (9-12) was 4% and 3% of patients Severe GCS (3-8). The overall mortality rate was 4.5%.
The Abuse and Misuse of Over-the-Counter Medicines During COVID-19
Authors: Al Meslamani Ahmad Z. , Abdel-Qader Derar H.
Published: March 2023

The abuse and misuse of OTC medicines is a common problem in community pharmacies and is expected to escalate during the COVID-19 pandemic. However, there is limited research on the patterns, causes, and consequences of these incidents during the pandemic. This article aims to provide evidence-based insights into the potential impact of COVID-19 on the abuse and misuse of OTC medicines, and suggest strategies for reducing these occurrences for pharmacy practitioners and healthcare managers.
How Do Fast-Fashion Copycats Affect the Popularity of Premium Brands? Evidence from Social Media
Authors: Shi Zijun (June) , Liu Xiao , Lee Dokyun , Srinivasan Kannan
Published: March 2023

The erosion of high-end fashion brands by fast-fashion copycats (e.g., Zara, H&M) has stirred controversies and unceasing legal attempts to copyright fashion designs. Despite the purported negative impact of copycats, the effect of fashion copycats on high-end brands remains empirically unclear. Research on this topic has been impeded by the absence of a modeling framework to quantify fashion and by the lack of consumer-level data on fashion choices. The authors collect data on the posting behaviors of consumers on a fashion-specific social media platform and develop a dynamic structural model with deep learning image analytics to characterize consumers’ choices of brands and styles. Results suggest that fast-fashion copycats can both harm high-end brands (a cannibalization effect) and help them (a market expansion effect). The authors also identify both static and dynamic mechanisms that contribute to the market expansion effect: The affordability of mixing copycats with high-end brands boosts the number of high-end items featured in posts by financially constrained consumers (a static mechanism). In addition, good styles from copycats enable users to build their popularity on social media over time, which may increase the users' valuation of high-end brands and reduce the users' future costs via sponsorship opportunities (dynamic mechanisms). The results could inform policy makers about the potential consequences of prohibiting fashion copycats.
Beyond ‘Imagined Meritocracy’: Distinguishing the Relative Power of Education and Skills in Intergenerational Inequality
Authors: Araki Satoshi
Published: March 2023

Scholars argue the dominant discourse of meritocracy legitimises intergenerational inequality and the winner–loser divide. However, is our society really meritocratic? If yes, the relative power of educational qualifications per se should be smaller than that of skills/abilities in the labour market. Using the standardised data in the United States, structural equation modelling shows (1) the contribution of family background to educational attainment is as large as that to skills acquisition; but (2) the economic return to education is substantially larger than that to skills; and consequently (3) the role of education outweighs that of skills in forming social stratification. This suggests that contemporary USA is a typical credential society, where credentialism prevails over skills-based meritocracy. Nonetheless, people may misbelieve the society is meritocratic – imagined meritocracy – by conflating the levels/influences of education and skills. It is essential to distinguish these two traits and understand the credential/meritocratic nature of our society.
Synodality and the Francis Pontificate: A Fresh Reception of Vatican II
Authors: Gaillardetz Richard R.
Published: March 2023

The ten-year Francis pontificate represents a fresh reception of the Second Vatican Council. The full dimensions of this reception can be apprehended through the lens of synodality, the leitmotif of the Francis papacy. This article will consider four features of synodality exhibited in the papal magisterium of Pope Francis that help us appreciate the ways in which Francis has creatively received conciliar teaching and advanced the conciliar agenda.
Restoring Social Trust: From Populism to Synodality
Authors: Keenan James F.
Published: March 2023

Social trust has been compromised locally, nationally, and globally, and very recently more and more social scientists, ethicists, theologians, and civic leaders have highlighted its necessity for the function of social life. This article reviews the ways that social trust has been jeopardized and engages indicators that attempt to find where the trust is most at risk and what the better responses to it might be. It then turns to two collective gatherings, populism and synodality, to consider how we might better respond to these different forms of collective movements or gatherings so as to further the restoration of social trust.
The Holy Spirit as the Protagonist of the Synod: Pope Francis’s Creative Reception of the Second Vatican Council
Authors: Moons Jos
Published: March 2023

This article argues that Pope Francis’s conviction that the Holy Spirit guides the synodal journey represents a creative reception of the Second Vatican Council. By highlighting the Spirit’s agency, Francis offers an alternative to Lumen Gentium’s often ornamental pneumatology. While thus confirming the council’s theological rather than institutional understanding of the church, he complements its christocentric focus. Moreover, by imagining synodality as a journey of dialogical listening and discerning, the pope emphasizes the practical dimension of ecclesiology, something that recalls the council’s pastoral spirit.
Reconfiguring Ignacio Ellacuría’s Symbolic Conception of “the Crucified People”: Jesus, the Suffering Servant, and Abel
Authors: Castillo Daniel P.
Published: March 2023

This article offers an appreciative but critical appraisal of Ignacio Ellacuría’s concept of “the crucified people,” which identifies the oppressed peoples of history with both Jesus and the Suffering Servant. In formulating his concept, Ellacuría does not sufficiently delineate the potential volitional differences between Jesus, the Servant, and the crucified peoples of history. As a result, the symbol of the crucified people can present potentially distorted understandings of the relationship between suffering and redemption, distortions that Ellacuría himself would disavow. After surfacing these concerns, I argue that broadening the symbolic framework of the symbol of the crucified people to include not only Jesus and the Servant but also the figure of Abel can protect against these potential distortions.
The Effect of a Training Video With Audio Description on the Breast Self-Examinations of Women With Visual Impairments
Authors: Çelik Sultan , Çalım Selda İldan
Published: March 2023

Introduction: Breast cancer is a significant health problem affecting the health of women globally. Breast self-examination is a procedure applied for the early detection of breast cancer. Given the barriers that women with visual impairments face to access health care and health education, there is a need to develop materials for breast self-examination training as a skills-based practice for this group. This study evaluated the effect of a training video with an audio description on the breast self-examination of women who were visually impaired. Methods: The universe of this quasi-experimental study comprised women who were visually impaired ( N = 70) who were registered members of the Manisa Altinokta Blind Association in Turkey. The women who participated in the study volunteered and met the selection criteria ( n = 60). They were divided into two groups by lot. The audio description group listened to a breast self-examination training video with an audio description ( n = 30). The control group listened to the training video accompanied by typical sound, without audio description ( n = 30). Before and after a training video, all women performed breast self-examination on a female mannequin torso. The skills of women in breast self-examination were evaluated using a checklist by a midwife who was non-researcher. Results: The skills differed significantly between the two groups after the video training ( p < 0.05). The audio description group correctly performed most of the skills required for breast self-examination. None of the women in the groups were able to apply steps for such self-examination before the training. Discussion: A breast self-examination training video with audio description can improve the self-examination skills of women with visual impairments. Implications for Practitioners: Women with visual impairments benefit from watching a breast self-examination training video with an audio description before performing self-examinations. Training videos with audio descriptions should, therefore, be prepared for the health education of individuals who are visually impaired.
Refractory Epistaxis: A Map is Enough!
Authors: Deng Huiyi , Wang Weihao , He Lifeng , Yang Qintai
Published: March 2023

Combined the big data from Chinese researches and our clinical experiences, we drew a concise “distributed map” of intractable epistaxis showing the concealed bleeding regions and offending vessels clearly ( Figure 1 ). The bleeding site was located accurately according to the “distributed map,” and bleeding was stopped via bipolar radiofrequency ablation under nasal endoscope without nasal packing, followed by five classic cases ( Figure 2 ). It is our recommended precise mode of diagnosis and treatment of refractory epistaxis.
Pneumothorax in acute respiratory distress syndrome on extracorporeal membrane oxygenation support
Authors: Shah Aakash , Naselsky Warren , Dave Sagar , Young Bree Ann , Bittle Gregory , Tabatabai Ali , Friedberg Joseph , Krause Eric
Published: March 2023

Introduction

Pneumothorax is associated with poor prognosis in patients with acute respiratory distress syndrome (ARDS). We sought to examine the outcomes of patients who are supported on veno-venous extracorporeal membrane oxygenation (VV ECMO) and develop a pneumothorax.

Methods

We retrospectively reviewed all adult VV ECMO patients supported for ARDS between 8/2014-7/2020 at our institution, excluding patients with recent lung resection and trauma. Clinical outcomes were compared between patients with a pneumothorax to those without a pneumothorax.

Results

Two hundred eighty patients with ARDS on VV ECMO were analyzed. Of those, 213 did not have a pneumothorax and 67 did. Patients with a pneumothorax had a longer duration of ECMO support (30 days [16–55] versus 12 [7–22], p < 0.001) and hospital length of stay (51 days [27–93] versus 29 [18–49], p < 0.001), and lower survival-to-discharge (58.2% versus 77.5%, p = 0.002) compared to patients without a pneumothorax. Controlling for age, BMI, sex, RESP score and pre-ECMO ventilator days, the odds ratio of survival-to-discharge was 0.41 (95% CI 0.22–0.78) in patients with a pneumothorax compared to those without. There was a lower incidence of significant bleeding when chest tubes were placed by proceduralist services (2.4% versus 16.2%, p = 0.03). Removal of the chest tube prior to ECMO decannulation compared to removal after decannulation was associated with need for replacement (14.3% versus 0%, p = 0.01).

Conclusion

Patients who develop a pneumothorax and are supported with VV ECMO for ARDS have longer duration on ECMO and decreased survival. Further studies are needed to assess risk factors for development of pneumothorax in this patient population.
Biomechanical Stability of Lateral Ulnar Collateral Ligament Reconstruction and Repair of the Elbow: The Role of Ligament Bracing on Gap Formation and Stabilization
Authors: Bachmaier Samuel , Wijdicks Coen A. , Verma Nikhil N. , Higgins Laurence D. , Greiner Stefan
Published: March 2023

Background:

Augmented (internal braced) lateral ulnar collateral ligament (LUCL) repair has been biomechanically compared with reconstruction techniques in the elbow. However, LUCL repair alone has not yet been compared with augmented repair and reconstruction techniques.

Hypothesis:

Internal bracing of LUCL repair would improve time-zero stabilization regarding gap formation, stiffness, and residual torque as compared with repair alone and reconstruction techniques to restore native elbow stability.

Study Design:

Controlled laboratory study.

Methods:

Overall, 24 cadaveric elbows were used for either internal braced LUCL repair (Repair-IB) or single- and double-strand ligament reconstruction with triceps (Recon-TR) and palmaris longus tendon graft (Recon-PL), respectively. Laxity testing in external rotation was consecutively performed at 90° of elbow flexion on the intact, dissected, and repaired conditions and with the previously assigned techniques. First, intact elbows were loaded to 7.0-N·m external torque to evaluate time-zero ligament rotations at 2.5, 4.0, 5.5, and 7.0 N·m. Rotation-controlled cycling was performed (total of 1000 cycles) for each surgical condition. Gapping, stiffness, and residual torque were analyzed. Finally, these and 8 additional intact elbows underwent torque-to-failure testing (30 deg/min).

Results:

The dissected state showed the highest gap formation and lowest peak torques ( P < .001). While gap formation of Repair-IB ( P < .021) was significantly lower than that of repair without internal bracing at all rotation levels, gaps of Recon-PL were similar to and Recon-TR were significantly higher than those of Repair-IB except for the highest torsion level. Residual peak torques at specific rotation angles between native state and Recon-TR (α2.5), Recon-PL (α4.0), and Repair-IB (α5.5) were similar; all other comparisons were significantly different ( P < .027). Torsional stiffness of Repair-IB was significantly higher at all rotation angles measured. Analysis of covariance showed significantly less gap formation over residual peak torques for Repair-IB ( P < .001) as compared with all other groups. The native state failure load was significantly higher than Recon-PL and Recon-TR failure loads, with similar stiffness to all other groups.

Conclusion:

Repair-IB and Recon-PL of the LUCL showed increased rotational stiffness relative to the intact elbow for restoring posterolateral stability to the native state in a cadaveric model. Recon-TR demonstrated lower residual peak torques but provided near-native rotational stiffness.

Clinical Relevance:

Internal bracing of LUCL repair may reduce suture-tearing effects through tissue and provide sufficient stabilization for healing throughout accelerated and reliable recovery without the need for a tendon graft.
Anatomic Features of Patients With Recurrent Peroneal Tendon Dislocation
Authors: Nishimura Akinobu , Nakazora Shigeto , Senga Yoshiyuki , Fukuda Aki , Sudo Akihiro
Published: March 2023

Background:

There are several anatomic variations of the peroneal muscles and lateral malleolus of the ankle that may play an important role in the onset of peroneal tendon dislocation.

Purpose:

To investigate the anatomic variations of the retromalleolar groove and peroneal muscles in patients with and without recurrent peroneal tendon dislocation using magnetic resonance imaging (MRI) and computed tomography (CT).

Study Design:

Cross-sectional study; Level of evidence, 3.

Methods:

A total of 30 patients (30 ankles) with recurrent peroneal tendon dislocation who underwent both MRI and CT before surgery (PD group) and 30 age- and sex-matched patients (control [CN] group) who underwent MRI and CT were included in this study. The imaging was reviewed at the level of the tibial plafond (TP level) and at the center slice between the TP and the fibular tip (CS level). The appearance of a malleolar groove (convex, concave, or flat) and the posterior tilting angle of the fibula were assessed on CT images. The appearance of accessory peroneal muscles, height of the peroneus brevis muscle belly, and volume of the peroneal muscle and tendons were assessed on MRI scans.

Results:

There were no differences in the appearance of the malleolar groove, posterior tilting angle of the fibula, or accessory peroneal muscles at the TP and CS levels between the PD and CN groups. The peroneal muscle ratio was significantly higher in the PD group than in the CN group at the TP and CS levels (both P < .001). The height of the peroneus brevis muscle belly was significantly lower in the PD group than in the CN group ( P = .001).

Conclusion:

A low-lying muscle belly of the peroneus brevis and a larger muscle volume in the retromalleolar space were significantly associated with peroneal tendon dislocation. Retromalleolar bony morphology was not associated with peroneal tendon dislocation.
Understanding Criminogenic Risk Factors Among United States Military Veterans: An Updated Literature Review
Authors: Edwards Emily R. , Epshteyn Gabriella , Connelly Brigid , Redden Clare , Moussa Christelle El Hage , Blonigen Daniel M. , Stimmel Matthew , Holliday Ryan , Osterberg Terra
Published: March 2023

Justice-involved veterans (JIVs) are a high-priority subgroup within the U.S. judicial system. In recent years, empirical research into the characteristics, needs, and outcomes of this veteran subgroup has developed rapidly. To allow research to better inform efforts to support JIVs, a systematic review was completed to organize existing literature on criminogenic risk within this population through the lens of the Risk-Need-Responsivity Model. Of the eight risk factors theorized by the Risk-Need-Responsivity Model, history of antisocial behavior and substance use had the most robust evidence as criminogenic risk factors for veteran justice involvement. Modest evidence was identified for antisocial personality, educational and occupational difficulties, and disruptions to family and marital relationships as risk factors. However, only limited evidence was identified for antisocial thinking, affiliation with antisocial peers, and lack of prosocial activities as risk factors due to these factors being relatively underassessed in research. Such patterns provide insight into potential interventions and supports for JIVs while also highlighting areas for continued research.
Embracing Opportunity and Bracing for the Future: Renewal Discourse and Inoculation
Authors: Dillingham Lindsay L.
Published: March 2023

This paper explores the potential to address mid-crisis communication needs in longitudinal crises by using a paired renewal discourse and inoculation messaging strategy. While renewal discourse focuses on inherent opportunities and the possibility for organizations to improve following a crisis, insulating stakeholder views from ongoing and future crisis effects with inoculation messaging during the crisis can improve the durability of positive outcomes. Theoretically driven rhetorical analysis is used to examine stakeholder communication from one of the two firms that survived The Weekend Wall Street Died in September 2008, a midpoint in the 18-month global financial meltdown. The results demonstrate mid-crisis as a distinct communication exigency and the applied use of a paired renewal discourse and inoculation strategy as a crisis and ongoing risk management approach.
Online Hate Speech as a Moral Issue: Exploring Moral Reasoning of Young Italian Users on Social Network Sites
Authors: Ieracitano Francesca , Balenzano Caterina , Girardi Sabrina , Gemmano Cataldo Giuliano , Comunello Francesca
Published: March 2023

Taking a neo-Kohlbergian approach, we explore the moral reasoning of 486 young Italian users of social network sites exposed to moral dilemmas concerning online hate speech. The aims are to understand what moral reasoning schemas they use as they face homophobic, racist, or sexist online hate speech, and what influence personal values and moral disengagement might have on their moral reasoning process. The results reveal the prevalence of Maintaining Norms reasoning (conformity to rules and authority) in making moral decisions concerning online hate speech and confirms the mediating role of Hate Speech Moral Disengagement in the relationship between personal values and the moral reasoning process.
Performance investigation on novel combined power generation and refrigeration system
Authors: Uma Maheswari G , Ganesh N Shankar , Srinivas Tangellapalli , Reddy Bale Viswanadha
Published: March 2023

This article aims to examine a novel combined power and refrigeration system, using renewable and waste heat sources suitable for low-temperature applications. The present system is an integrated Kalina cycle and ejector refrigeration system to generate power and refrigeration simultaneously. To improve the vapour generation, the separator vapour fraction is used as a decision variable. Relative irreversibility and efficiency defect as two important parameters considered in this system for an investigation to identify the weaker components. The combined system generates power and refrigeration with two different mediums by the incorporation of the heat exchanger at the turbine exhaust. The novel system's energy and conventional exergy evaluation are carried out through Python Software. The optimum values of decision variables: turbine concentration, separator vapour fraction, entrainment ratio, expander ratio, split ratio and turbine concentration are identified using Python software from an opted range of variables. The maximum value of net power output, first law efficiency for power generation system, combined system, second law efficiency for power generation system, combined system, refrigeration effect and coefficient of performance are obtained as 113 kW, 8.85%, 11.83%, 93.44%, 81.29%, 38.07% and 0.118, respectively, at higher separator vapour fraction. Among the components considered in the combined power generation system, the condenser and LTRGN account for the higher exergy destruction rate of 30.41% and 25.53%. The coefficient of performance is maximized at a higher value of the refrigeration effect. The turbine pressure at the inlet is increased with increments in turbine work on choosing the higher value of the expander ratio. The higher exergetic value components are not emphasized to focus on improvement.
“Extremely Depressed with a Hopeless Outlook”: The Experiences of Psychologically Traumatized Nursing Sisters During and After the First World War
Authors: Rosenthal Lyndsay
Published: March 2023

During the First World War, 2,845 women served as nursing sisters with the Canadian Army Medical Corps. Although the majority of those who enlisted had pre-war training, these experiences did not prepare them for the severity of the injuries they treated, the relentless pace of the work, and the pressures of working within a warzone. How did these women cope with the traumas they witnessed during their service when they returned home? Of the 842 nursing sisters who applied for a pension, 143 (16.7%) reported ongoing mental and nervous illnesses. The postwar experiences of these women reveal some of the traumas and challenges that military nurses faced overseas and when they returned home.
At the Intersection: The Influence of Race on Women’s Leadership Self-Efficacy Development
Authors: Ruggs Enrica N. , Bilotta Isabel , Membere Ashley , King Eden B. , Shelby Rosette Ashleigh
Published: March 2023

Leadership self-efficacy (LSE), one’s beliefs in their own ability, knowledge, and skills in leading others effectively, can play a large role in how individuals develop and perform as leaders. Understanding the dynamics of LSE growth may be particularly important when considering the development of female leaders. The institutional barriers and gender inequities experienced by women can change the trajectory of their course to leadership; however, the ways in which the course changes likely differ as a function of intersecting identities. Rather than presume all women share common leadership development opportunities and experiences, we contend that women’s LSE is informed by experiences unique to their racial and ethnic backgrounds. According to intersectionality theory, individuals are part of multiple social categories that can shape their experiences. In the current paper, we focus on how the intersection of gender and race influence the development of LSE across the life span for White, Black, Asian American women, and Latinas. Integrating social cognitive theory with intersectionality theory, we explore how gendered and racialized experiences prior to and during adulthood shape women’s leadership self-efficacy. We also discuss ways that organizations can help reduce and counteract negative consequences of barriers to LSE for different women.
Implementation of the Management of Anticoagulation in the Periprocedural Period App into an Electronic Health Record: A Cost-Effectiveness Analysis
Authors: Wang Jason J. , Koulas Ioannis , Myrka Anne , Spyropoulos Alex C.
Published: March 2023

The Management of Anticoagulation in the Periprocedural Period (MAPPP) app is a free tool providing up-to-date guidelines on the periprocedural management of patients on long-term anticoagulants. After validating its effectiveness in the post-procedural period, we aimed to study its overall cost-effectiveness. SF-12 surveys were sent to eligible patients, converted into SF-6D forms, and subsequently into quality-adjusted life years (QALYs) to calculate the incremental cost-effectiveness ratio (ICER). The number of 30-day readmissions was used to calculate hospitalization costs, utilizing publicly available data. From 1/1/2018 to 1/31/2019, 642 patients were screened for enrollment, with an overall response rate of 94% (164/175) among the consented and 49% (164/336) among all eligible patients. The average QALY score was 0.7134 (95% CI [0.6836, 0.7431]) for the patients whose treatment plan followed the MAPPP app recommendations (acceptance group) and 0.7104 (95% CI [0.6760, 0.7448]) for those who did not (rejection group), without statistically significant differences. The difference in ICER scores was −$429 866.67, with the negative sign demonstrating that acceptance was the dominant strategy. By utilizing QALYs and ICER scores we have shown that the acceptance of MAPPP app recommendations is the dominant strategy for the periprocedural management of patients on long-term anticoagulation.
An election too far: Why do MPs leave politics before an election?
Authors: Weber Anthony , Bodet Marc André , Gélineau François , Blais André
Published: March 2023

Why do members of parliament retire? In most parliamentary systems, a substantial number of MPs decide, before every election, not to run again. Though the decision to leave politics is essentially personal, a broader look at a large sample of MPs can reveal the existence of structural factors such as an uneven playing field or other sources of discrimination that could explain why certain individuals stay while others leave. A survey of the current literature indicates that the empirical work on this topic is almost exclusively focused on the US Congress. There is thus a need to conduct more research in other contexts to generate a more general explanation of why MPs leave politics on their own terms. The current literature suggests that the decision to leave could be explained by a complex combination of variables that are personal, partisan, and contextual. The purpose of this article is to better understand why sitting MPs decide not to run for re-election in parliamentary systems, focusing on three Westminster systems: Australia, Canada, and New Zealand since 1945. Various factors play a role, but our results suggest that as time passes, parliamentarians simply become less prone to seeking reelection.
Analyzing the Justice and Development Party’s changing discourse on the headscarf issue as the constitutive part of its drift toward authoritarian politics in Turkey
Authors: Yarar Betül
Published: March 2023

Despite its long history since the late Ottoman period in Turkey, this article focuses on the headscarf issue within a particular period; since 2002, when the Justice and Development Party has been in power. Women’s issues have always occupied a large space in the Justice and Development Party’s project(s), which articulate diverse narrative lines ranging from conservatism to liberalism. The article aims to unravel this diverse insight into the Justice and Development Party’s politics within the context of its recent political drift toward authoritarianism while particularly focusing on its headscarf discourses. It argues that the Justice and Development Party’s political drift toward authoritarianism resulted in the replacement of the earlier politics of consensus/‘non-defiance’, which refers to a conservatism that denies radicalism and avoids emphasizing controversial issues like the headscarf, with the politics of dissensus/defiance that reveal social tensions and political conflicts such as those between Islamic and secular sectors, through revitalizing the old debate on the headscarf issue. In this sense, the lifting of the headscarf bans in public institutions in 2008 can be read as a symptom, not of the Justice and Development Party’s earlier liberal stand, but of the beginning of its shift toward authoritarianism based on its religious-nationalist project, which made use of this liberal right of pious women in enhancing the gaps between oppositional groups and in consolidating its social basis. This earlier attempt has been followed by continuous use of the headscarf as a symbol drawing a border between ‘us’ and ‘them’ and signifying outrages and moral crisis for which the Justice and Development Party blamed the oppositional groups. Within this context, the article questions the ways in which the headscarf as a political symbol along with other conservative policies targeting female bodies and sexualities took a part in the constitution and consolidation of the Justice and Development Party’s radical right alliance and its authoritarian regime.
Juggling identities: Identification, collective memory, and practices of self-presentation in the United Nations General Debate
Authors: Adams Tracy , Mitrani Mor
Published: March 2023

The concept of collective memory receives increasing attention in international relations. This burgeoning scholarship, however, mainly centres on its role as a strategic tool in foreign policy, binding it to national context. This research uses collective memory as an analytical framework to gauge identification processes at the international level. Specifically, we examine how states self-present themselves with various collective We’s and against multiple others. Contingent upon exclusive biographical narratives, we show how states transform and present collective memories in ways that resonate with their particular identity combination. Using inductive comparative analysis of speeches delivered by heads of state of Germany, the United States, and Israel during United Nations General Assembly sessions (1991–2017), analysis demonstrates how states evoke the past to narrate who they are, as states. Expanding understanding regarding how historical events are utilised in foreign policy, findings illustrate the dynamic juggling process states perform with various elements of self.
The moral license of a click: How social observability and impression management tendencies moderate the effects of online clicktivism on donation behavior
Authors: Kim Nuri , Kim Hye Kyung , Tan Si Jin , Wang Wen Hsing Kelvin , Ong Kheng Hian
Published: March 2023

Token acts of online support, also known as clicktivism, have received much criticism in recent years for suppressing subsequent prosocial behavior. However, whether, when, and why individuals perform less prosocial behavior following these acts remains relatively unknown. To address these questions, we designed a lab experiment in which participants ( N = 193) were randomly assigned to engage in public, private, or no act of clicktivism. Consistent with moral self-licensing theory, those who signed an online petition were less likely to donate than those who did not sign any petition. Public clicktivism (compared to private clicktivism) increased donation intentions among those with high impression management tendencies (i.e. high self-monitors). Concerns about one’s moral self-image partially mediated these effects. Theoretical and practical implications of these findings are discussed.
Mechanical properties and defects in friction stir welded acrylonitrile butadiene styrene polymer
Authors: Arif Mohammad , Kumar Dilip , Siddiquee Arshad Noor
Published: March 2023

In this research work, a butt joint between acrylonitrile butadiene styrene (ABS) sheets was made using Friction stir welding (FSW). Polymers such as ABS have great potential to be used as body parts in automotive industries because of their high strength-to-weight ratio. In the aerospace industry, polymers are preferred over metals as they can retain their properties at low temperatures and their light weight reduces fuel consumption. The objective of this research work was to investigate mechanical properties and defect characterization in weldments. Maximum weld strength achieved was 19.4 MPa which is 61% of the base material at a rotational speed of 224 r/min, travel speed of 50 mm/min, external heating temperature of 45°C, and shoulder diameter of 16 mm. The images of macro and microstructure from an optical microscope and scanning electron microscope, respectively, showed that in FSW of ABS polymer defects were mainly formed on the retreating side of the weld nugget, unlike FSW of metals having it on the advancing side. Only two experiments out of L18 experiments showed tunneling defect, i.e., Experiment no. 8 and Experiment no. 10 and four experiments showed undercutting defect, i.e., Experiment no. 6, 9, 12, and 18. By performing the Vickers microhardness test it was observed that the hardest region formed in and around the weld nugget.
Body integrity dysphoria and medical necessity: Amputation as a step towards health
Authors: Gibson Richard B
Published: March 2023

Interventions are medically necessary when they are vital in achieving the goal of medicine. However, with varying perspectives comes varying views on what interventions are (un)necessary and, thus, what potential treatment options are available for those suffering from the myriad of conditions, pathologies and disorders afflicting humanity. Medical necessity's teleological nature is perhaps best illustrated in cases where there is debate over using contentious medical interventions as a last resort. For example, whether it is appropriate for those suffering from body integrity dysphoria to receive healthy limb amputations. This paper explores how one's perception of medicine's goal underpins whether interventions are necessary or unnecessary, using the controversial topic of therapeutic amputation as an example. By contrasting ‘classical’ amputations with their more contentious counterparts, it highlights how the idea of medical necessity influences and restrains clinical decision-making. The paper starts by giving an account of body integrity dysphoria, focusing on the debate concerning elective amputation's justifiability. It then introduces Georges Canguilhem's vitalist theory of health, paying particular attention to his emphasis on adaptability. Then, this paper uses his theory as a lens through which to evaluate the appropriateness of therapeutic amputation as a medically necessary procedure. Ultimately, the paper highlights how the label of medical necessity is withheld from potential therapeutic interventions because they fail to conform to pre-established ideas of medicine's purpose and that by doing so, potential harm befalls those who are left with no effective treatments and must look for solutions in the non-clinical world.