bluuebunny/crossref_metadata_2025 huggingface dataset:
El patrimonio devocional en culto activo. Buenas prácticas para su conservación
Authors: Montero Montero Araceli , Pérez Cano Valle , Villanueva Romero Eva
Published: June 2024

La trayectoria profesional del Instituto Andaluz del Patrimonio histórico (IAPH) destaca por la consolidación de una metodología de trabajo en las intervenciones de los bienes culturales de diversas tipologías. Partiendo de los principios claves de esta forma de trabajar, donde el conocimiento es la base de las acciones directas, la institución ha ido innovando en metodologías que dan respuestas a determinadas demandas de la ciudadanía. Estas respuestas son fruto de la experiencia y evolución de sus procedimientos en su continua adaptación a modelos de intervención más sociales y sostenibles.
Home Education: Needs, Challenges, and the Role of Higher Education Institutions
Authors: Rubio-Negrón Esther A.
Published: June 2024

Home education has garnered significant attention from governments worldwide. This educational approach prompts inquiries about quality, social-emotional development, potential child abuse, curriculum, academic outcomes, and parental involvement. Despite its historical presence in the United States since the 1900s, homeschooling has experienced gradual growth, influenced by regulatory efforts and family dynamics. The emergence of COVID-19 further accelerated this trend, with the number of homeschooling families in the US rising from 1,690,000 in 2016 to 2.6 million in 2020 and reaching 3 million by 2021 Globally, over 300 million families have embraced this educational model. This research employs a mixed, non-experimental, descriptive methodology and focuses on Puerto Rico. It examines demographic data, needs, and obstacles encountered by homeschooling families, categorizing them by groups, regions, teaching methods, and religious affiliations. Additionally, the study explores the role of universities as potential partners in supporting and serving homeschooling families. Furthermore, we present international research findings on academic achievement and socialization among homeschooled students, drawing from several studies and university entrance scores.
Artificial intelligence in healthcare administration: Topic modeling with InfraNodus
Authors: Gunawan Joko
Published: June 2024

N/A
‘The poetry of earth is never dead’: Meteorology and Myth in Keats’s Grasshopper Sonnet
Authors: Comet Noah
Published: June 2024

Keats’s 1816 competition sonnet ‘On the Grasshopper and Cricket’ is easily dismissed as juvenilia, but when read with an eye to his interest in Greek mythology, the poem rewards further attention. In particular, the myth of Tithonus, who gained eternal life without eternal youth and was transformed into either a grasshopper or cricket, situates Keats’s immortal ‘poetry of earth’ in an ambivalent context that, in turn, makes sense of otherwise curiously neutral language. This ambivalent framing also encourages a new reading of the poem as a product of 1816, ‘the year without a summer’, building a case for the sonnet as an example of what Nikki Hessell has called Keats’s ‘botany of absence’ in the 1817 Poems volume more broadly.
On Sitting Down with John Keats
Authors: Thomson Heidi
Published: June 2024

In this essay I focus on the phenomenon of ‘sitting down’ in Keats's letters and poems. Sitting down, in Keats's personal interactions and poetics, has a range of connotations: these range from exercising individual, focused concentration on the task ahead, to enjoying companionable, shared creativity; from maintaining a certain bedside manner, to establishing a long-distance relationship with siblings; from reluctantly resigning oneself to an invalid existence, to summoning the resourceful energy to compose poetry. For Keats, the expression of sitting down points to the required stillness for the imagination to take flight in poetry, but it also features prominently in self-portrayals throughout his correspondence. This essay demonstrates how sitting down, for Keats, is a transformative act with far more dynamic connotations than is usually assumed.
Memorialising Keats: Severn, Headstones and Hyperion
Authors: Scott Grant F.
Published: June 2024

For obvious reasons, Keats's biographers have focused primarily on the last five months of the poet’s life and on the making of his reputation in the later nineteenth century. They have spent very little time, however, on the two uncertain years that followed the poet’s death when his legacy, largely in the hands of Brown, Taylor and Severn, hung in the balance. As Severn was recovering from Keats's death, he fought to establish his own livelihood as a painter and find an adequate means of memorialising his friend. He was preoccupied with two works of art, The Death of Alcibiades and the headstone for Keats's grave. I argue that these artworks represent complex expressions of Severn's grief and in this sense are both memorials, though Alcibiades disguises its aims in a conventional historical painting. In the strong reading of Hyperion embedded in the picture, Severn finds a way of coming to terms with the traumatic aftermath of Keats's death as well as the critical attacks on his poetry. My recent rediscovery of two key manuscript letters of this time by members of the Keats Circle lends support to the argument.
Estimation
of carbon footprint of Indian households in Kalyani subdivision of district Nadia, West Bengal, India
Authors: Dey Madhushree , Kumar Gautam Rajesh , Bijayasundari Devi Aribam
Published: June 2024

The present study aims to assess the contribution of Indian households to the increase in carbon footprint. Hence, this cross-sectional study was conducted in the Kalyani subdivision of Nadia district, West Bengal, India. Data were collected from 610 households, comprising 299 rural and 311 urban households, to analyse energy consumption patterns for various purposes. To summarize the dependent and continuous data, descriptive statistics were employed, while for inferences, independent sample t-test, Pearson correlation and regression were used. A significant difference was observed in total annual household carbon footprint between the urban and rural households due to varied energy consumption (t = 15.60, p < 0.05). The urban households were emitting twice (2325.20 kgCO2e) as much as the rural ones (1125.77 kgCO2e). It can also be inferred that emission was determined by the increase in household size, income, and improvement in the standard of living. Thus, in addition to several determinants, a complex cultural system, social practices, and awareness of green consumerism should also be incorporated and studied through an interdisciplinary approach to reduce the overall household carbon footprint.
The evolution of mammalian Rem2: unraveling the impact of purifying selection and coevolution on protein function, and implications for human disorders
Authors: Lucaci Alexander G. , Brew William E. , Lamanna Jason , Selberg Avery , Carnevale Vincenzo , Moore Anna R. , Kosakovsky Pond Sergei L.
Published: June 2024

Rad And Gem-Like GTP-Binding Protein 2 (Rem2), a member of the RGK family of Ras-like GTPases, is implicated in Huntington’s disease and Long QT Syndrome and is highly expressed in the brain and endocrine cells. We examine the evolutionary history of Rem2 identified in various mammalian species, focusing on the role of purifying selection and coevolution in shaping its sequence and protein structural constraints. Our analysis of Rem2 sequences across 175 mammalian species found evidence for strong purifying selection in 70% of non-invariant codon sites which is characteristic of essential proteins that play critical roles in biological processes and is consistent with Rem2’s role in the regulation of neuronal development and function. We inferred epistatic effects in 50 pairs of codon sites in Rem2, some of which are predicted to have deleterious effects on human health. Additionally, we reconstructed the ancestral evolutionary history of mammalian Rem2 using protein structure prediction of extinct and extant sequences which revealed the dynamics of how substitutions that change the gene sequence of Rem2 can impact protein structure in variable regions while maintaining core functional mechanisms. By understanding the selective pressures, protein- and gene - interactions that have shaped the sequence and structure of the Rem2 protein, we gain a stronger understanding of its biological and functional constraints.
Antimicrobial properties of hindered amine light stabilizers in polymer coating materials and their mechanism of action
Authors: Costa Tiago , Sampaio-Marques Belém , Neves Nuno M. , Aguilar Helena , Fraga Alexandra G.
Published: June 2024

UV-stabilizers are a class of additives that provide extended polymer resistance to UV-degradation, but have also been suggested to have antimicrobial activity, potentially preventing the spread of pathogens, and inhibiting microbial-induced biodegradation. In this work, we incorporated different UV-stabilizers, a hindered amine light stabilizer (HALS), Tinuvin 770 DF and Tinuvin PA 123, or a hybrid HALS/UV-absorber, Tinuvin 5151, in polyurethane formulations to produce lacquer-films, and tested their antimicrobial activity against Staphylococcus aureus (methicillin-resistant and -sensitive strains), Escherichia coli and Candida albicans. Lacquer-films incorporated with Tinuvin 770 DF showed strong antimicrobial performance against bacteria and fungi, while maintaining cytocompatibility. The mechanism of action revealed a positive relationship between Tinuvin 770 DF concentration, microbial death, and reactive nitrogen species (RNS), suggesting that RNS produced during autoxidation of Tinuvin 770 DF is responsible for the antimicrobial properties of this UV-stabilizer. Conversely, lacquer-films incorporated with Tinuvin 5151 or Tinuvin PA 123 exhibited no antimicrobial properties. Collectively, these results highlight the commercial potential of Tinuvin 770 DF to prevent photo- and biodegradation of polymers, while also inhibiting the spread of potentially harmful pathogens. Furthermore, we provide a better understanding of the mechanism underlying the biocidal activity of HALS associated to autooxidation of the amine group.
Semi-automated creation of IFC bridge models from point clouds for maintenance applications
Authors: Schatz Yohann , Domer Bernd
Published: June 2024

Bridge maintenance activities benefit from digital models, provided in the interoperable IFC format. Such a model, enriched with up-to-date information, is an enabler for a wide range of applications. It opens new perspectives in asset information management. However, the manual creation of a digital replica, representing the actual state of the asset from point cloud data, is time-consuming. Consequently, process automation is of particular interest. This paper proposes a systematic, semi-automatic approach for creating IFC bridge models from point clouds. It introduces new methods for semantic segmentation and 3D shape modeling. A case study demonstrates the feasibility of the process in practice. Compared to other solutions, proposed methods are robust when dealing with incomplete point clouds.
Development and validation of a prediction model for mortality in critically ill COVID-19 patients
Authors: Sun Xiaoxiao , Tang Jinxuan , Lu Jun , Zhang Hui , Li Cheng
Published: June 2024

Background

Early prediction of prognosis may help early treatment measures to reduce mortality in critically ill coronavirus disease (COVID-19) patients. The study aimed to develop a mortality prediction model for critically ill COVID-19 patients.

Methods

This retrospective study analyzed the clinical data of critically ill COVID-19 patients in an intensive care unit between April and June 2022. Propensity matching scores were used to reduce the effect of confounding factors. A predictive model was built using logistic regression analysis and visualized using a nomogram. Calibration and receiver operating characteristic (ROC) curves were used to estimate the accuracy and predictive value of the model. Decision curve analysis (DCA) was used to examine the value of the model for clinical interventions.

Results

In total, 137 critically ill COVID-19 patients were enrolled; 84 survived, and 53 died. Univariate and multivariate logistic regression analyses revealed that aspartate aminotransferase (AST), creatinine, and myoglobin levels were independent prognostic factors. We constructed logistic regression prediction models using the seven least absolute shrinkage and selection operator regression-selected variables (hematocrit, red blood cell distribution width-standard deviation, procalcitonin, AST, creatinine, potassium, and myoglobin; Model 1) and three independent factor variables (Model 2). The calibration curves suggested that the actual predictions of the two models were similar to the ideal predictions. The ROC curve indicated that both models had good predictive power, and Model 1 had better predictive power than Model 2. The DCA results suggested that the model intervention was beneficial to patients and patients benefited more from Model 1 than from Model 2.

Conclusion

The predictive model constructed using characteristic variables screened using LASSO regression can accurately predict the prognosis of critically ill COVID-19 patients. This model can assist clinicians in implementing early interventions. External validation by prospective large-sample studies is required.
Kv beta complex facilitates exercise-induced augmentation of myocardial perfusion and cardiac growth
Authors: Raph Sean M. , Calderin Ernesto Pena , Nong Yibing , Brittian Kenneth , Garrett Lauren , Zhang Deqing , Nystoriak Matthew A.
Published: June 2024

The oxygen sensitivity of voltage-gated potassium (Kv) channels regulates cardiovascular physiology. Members of the Kv1 family interact with intracellular Kvβ proteins, which exhibit aldo-keto reductase (AKR) activity and confer redox sensitivity to Kv channel gating. The Kvβ proteins contribute to vasoregulation by controlling outward K+ currents in smooth muscle upon changes in tissue oxygen consumption and demand. Considering exercise as a primary physiological stimulus of heightened oxygen demand, the current study tested the role of Kvβ proteins in exercise performance, exercise-induced adaptations in myocardial perfusion, and physiological cardiac growth. Our findings reveal that genetic ablation of Kvβ2 proteins diminishes baseline exercise capacity in mice and attenuates the enhancement in exercise performance observed after long-term training. Moreover, we demonstrate that Kvβ2 proteins are critical for exercise-mediated enhancement in myocardial perfusion during cardiac stress as well as adaptive changes in cardiac structure. Our results underscore the importance of Kvβ proteins in metabolic vasoregulation, highlighting their role in modulating both exercise capacity and cardiovascular benefits associated with training. Furthermore, our study sheds light on a novel molecular target for enhancing exercise performance and improving the health benefits associated with exercise training in patients with limited capacity for physical activity.
RNA editing landscape of adipose tissue in polycystic ovary syndrome provides insight into the obesity-related immune responses
Authors: Chen Hanxiao , Li Tongtong , Gao Rui , Cheng Meng , Zhang Qiong , Liu Xiumei , Chen Mingli , Liao Xin , Qin Lang
Published: June 2024

Background

Polycystic ovary syndrome (PCOS) is the most common reproductive–endocrine disorder with wide-ranging metabolic implications, including obesity. RNA editing, a post-transcriptional modification, can fine-tune protein function and introduce heterogeneity. However, the role of RNA editing and its impact on adipose tissue function in PCOS remain poorly understood.

Methods

This study aimed to comprehensively analyze RNA-editing events in abdominal and subcutaneous adipose tissue of PCOS patients and healthy controls using high-throughput whole-genome sequencing (WGS) and RNA sequencing.

Results

Our results revealed that PCOS patients exhibited more RNA-editing sites, with adenosine-to-inosine (A-to-I) editing being prevalent. The expression of ADAR genes, responsible for A-to-I editing, was also higher in PCOS. Aberrant RNA-editing sites in PCOS adipose tissue was enriched in immune responses, and interleukin-12 biosynthetic process. Tumor necrosis factor (TNF) signaling, nuclear factor kappa B (NF-κB) signaling, Notch signaling, terminal uridylyl transferase 4 (TUT4), hook microtubule tethering protein 3 (HOOK3), and forkhead box O1 (FOXO1) were identified to be of significant differences. Differentially expressed genes (DEGs) in PCOS adipose tissue were enriched in immune responses compared with controls, and the DEGs between subcutaneous and abdominal adipose tissue were also enriched in immune responses suggesting the important role of subcutaneous adipose tissue. Furthermore, we identified the correlations between RNA editing levels and RNA expression levels of specific genes, such as ataxia–telangiectasia mutated (ATM) and mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) in inflammation pathways and ATM, TUT4, and YTH N6-methyladenosine RNA-binding protein C2 (YTHDC2) in oocyte development pathway.

Conclusions

These findings suggest that RNA-editing dysregulation in PCOS adipose tissue may contribute to inflammatory dysregulations. Understanding the interplay between RNA editing and adipose tissue function may unveil potential therapeutic targets for PCOS management. However, further research and validation are required to fully elucidate the molecular mechanisms underlying these associations.
Tirzepatide against obesity and insulin-resistance: pathophysiological aspects and clinical evidence
Authors: Corrao Salvatore , Pollicino Chiara , Maggio Dalila , Torres Alessandra , Argano Christiano
Published: June 2024

Obesity is a chronic, multifactorial disease in which accumulated excess body fat has a negative impact on health. Obesity continues to rise among the general population, resulting in an epidemic that shows no significant signs of decline. It is directly involved in development of cardiometabolic diseases, ischemic coronary heart disease peripheral arterial disease, heart failure, and arterial hypertension, producing global morbidity and mortality. Mainly, abdominal obesity represents a crucial factor for cardiovascular illness and also the most frequent component of metabolic syndrome. Recent evidence showed that Tirzepatide (TZP), a new drug including both Glucagon Like Peptide 1 (GLP-1) and Glucose-dependent Insulinotropic Polypeptide (GIP) receptor agonism, is effective in subjects with type 2 diabetes (T2D), lowering body weight, fat mass and glycated hemoglobin (HbA1c) also in obese or overweight adults without T2D. This review discusses the pathophysiological mechanisms and clinical aspects of TZP in treating obesity.
Effect of oral glucose tolerance test-based insulin resistance on embryo quality in women with/without polycystic ovary syndrome
Authors: Hu Zhengyan , Zeng Rujun , Tang Yuanting , Liao Yingjun , Li Tao , Qin Lang
Published: June 2024

Objective

To explore the effects of insulin resistance (IR) on embryo quality and pregnancy outcomes in women with or without polycystic ovary syndrome (PCOS) undergoing in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI).

Methods

A retrospective cohort study concerning patients with/without PCOS who received gonadotropin-releasing hormone (GnRH)-antagonist protocol for IVF/ICSI from January 2019 to July 2022 was conducted. All the patients included underwent oral glucose tolerance test plus the assessment of insulin release within 6 months before the controlled ovarian stimulation. The Matsuda Index was calculated to diagnose IR. Two populations (PCOS and non-PCOS) were included and each was divided into IR and non-IR groups and analyzed respectively. The primary outcome was the high-quality day 3 embryo rate.

Results

A total of 895 patients were included (751 with PCOS and 144 without PCOS). For patients with PCOS, the IR group had a lower high-quality day 3 embryo rate (36.8% vs. 39.7%, p=0.005) and available day 3 embryo rate (67.2% vs. 70.6%, p<0.001). For patients without PCOS, there was no significant difference between the IR and non-IR groups in high-quality day 3 embryo rate (p=0.414) and available day 3 embryo rate (p=0.560). There was no significant difference in blastocyst outcomes and pregnancy outcomes for both populations.

Conclusion

Based on the diagnosis by the Matsuda Index, IR may adversely affect the day 3 embryo quality in patients with PCOS but not pregnancy outcomes. In women without PCOS, IR alone seems to have less significant adverse effects on embryo quality than in patients with PCOS. Better-designed studies are still needed to compare the differences statistically between PCOS and non-PCOS populations.
The association of composite dietary antioxidant index with periodontitis in NHANES 2009–2014
Authors: Meng Zihan , Zheng Wenzhuo , Meng Xiwei , Xu Hui
Published: June 2024

Background

To date, evidence is rare regarding whether and how dietary antioxidants are associated with the risk of periodontitis. This study aimed to investigate the association of composite dietary antioxidant index (CDAI) with periodontitis and tooth loss, using data from the National Health and Nutrition Examination Survey (2009–2014).

Methods

A cross-sectional analysis was conducted using data from 10,067 adults aged ≥30 years who underwent assessments of periodontal health and the 1st day dietary recall. Based on a crude model and three adjusted models, multivariate regressions were used to examine the relationship between CDAI and periodontitis-related measurements including probing pocket depth, clinical attachment loss and tooth loss. Subgroup analyses and the restricted cubic splines plots were applied to examine the association between CDAI ingredients and periodontitis.

Results

For the subjects with high CDAI scores, increased CDAI was associated with significant (P < 0.05) reduction of severe periodontitis (odd ratio = 0.663, 95% confidence interval: 0.491–0.896) and increased number of remaining teeth (weighted β[SE] = 1.167[0.211]). However, the protective effect of CDAI on periodontitis vanished (P > 0.05) in active smokers and former smokers. There were threshold levels for β-carotene, Vitamin A, C and E intakes where the risk of periodontitis significantly decreased (P < 0.05) above these levels.

Conclusion

Increased CDAI was associated with reduced risk of periodontitis and tooth loss for non-smokers. It was recommendable that proper dietary intakes of β-carotene, Vitamin A, C and E would be of benefit for preventive dental care and adjuvant therapies for periodontitis.
Associations between systemic inflammation indicators and nonalcoholic fatty liver disease: evidence from a prospective study
Authors: Gong Hao , He Qida , Zhu Lili , Feng Zhaolong , Sun Mengtong , Jiang Jingting , Yuan Xiaofeng , Shen Yueping , Di Jia
Published: June 2024

Background

Although inflammation has been linked to nonalcoholic fatty liver disease (NAFLD), most studies have focused only on a single indicator, leading to inconsistent results. Therefore, a large prospective study that includes a variety of well-documented single and composite indicators of inflammation is needed. This study aimed to thoroughly investigate the potential associations between different systemic inflammatory indicators and NAFLD in the UK Biobank cohort.

Methods

After excluding ineligible participants, 378,139 individuals were included in the study. Associations between systemic inflammatory indicators and hepatic steatosis were assessed using multivariate logistic regression. The relationships between systemic inflammatory indicators and nonalcoholic fatty liver disease were analysed using Cox proportional hazards models, and nonlinear associations were investigated using restricted cubic splines.

Results

According to the cross-sectional analysis, systemic inflammatory indicators significantly correlated with hepatic steatosis. Over a median follow-up of 13.9 years, 4,145 individuals developed NAFLD. After sufficient adjustment for confounding factors, CRP levels were found to be nonlinearly positively associated with NAFLD risk (P<0.001), representing the strongest correlation among the tested relationships; lymphocyte count and the LMR showed an L-shaped correlation; monocyte count and neutrophil count showed a linear positive correlation (all P< 0.001); and the NLR, PLR, and SII showed a U-shaped correlation (all P<0.001).

Conclusions

Multiple systemic inflammatory indicators are strongly associated with the development of NAFLD, and aggressive systemic inflammation management may have a favourable impact on reducing the burden of NAFLD; further randomized controlled studies are needed.
A single-center, retrospective study-spring-evaluating the efficacy and safety of recombinant human vascular endothelial inhibitor combined with anti-PD-1 in elderly patients aged 80 and above with NSCLC
Authors: Xing Tian , Gao Qianqian , Zhu Hongbin , Gao Jianrong , Yan Ganglin
Published: June 2024

Aim

To investigate the efficacy and safety of combining Recombinant Human Endostatin Injection (marketed as Endo) with anti-PD-1 in elderly patients aged 80 and above with non-small cell lung cancer (NSCLC).

Methods

Retrospective analysis of 181 patients with NSCLC aged 80 and above treated in the Department of Respiratory and Critical Care Medicine at Chaohu Hospital, affiliated with Anhui Medical University, from June 2019 to January 2024. Patients who received at least one cycle of combined Endo with anti-PD-1 were included based on inclusion criteria. Clinical and pathological data were collected, including complete blood count, liver and kidney function, electrocardiogram, coagulation function, thyroid function, cardiac enzymes, and whole-body imaging. Adverse events were recorded with a final follow-up on January 25, 2024. The primary endpoints were progression-free survival (PFS) and overall survival (OS), with safety as a secondary endpoint.

Results

This study involved 14 elderly patients with NSCLC aged over 80. Median progression-free survival (mPFS) was 102 days, and median overall survival (mOS) was 311 days. Subgroup analyses based on treatment cycles showed a non-significant 441-day mPFS increase in the long-term group (≥6 cycles, 5 patients) compared to the short-term group (<6 cycles, 9 patients). However, the mOS in the long-term group significantly exceeded the short-term group by 141 days, with statistical significance (P=0.048). Further categorization revealed a 204-day shorter mPFS in the monotherapy maintenance group (Endo or Immunol) compared to the combination maintenance group (Endo combined with Immunol, 441 days). The mOS of the monotherapy maintenance group was longer (686 days) than the combination maintenance group (311 days), but no statistical significance (P= 0.710, 0.920). Throughout the treatment, 77 adverse events were recorded, mainly grade 1–2, with no new treatment-related reactions occurred. Overall, the safety of Endo combined with anti-PD-1 was considered good and manageable.

Conclusion

The combination of Endo and anti-PD-1 could be an effective treatment choice for patients with NSCLC aged 80 and above.
Geochemical characteristics of the modern Yellow River Delta sediments and their response to evolution of the sedimentary environment
Authors: Meng Liwei , Wang Longsheng , Wang Qing , Zhao Jiawen , Zhang Guiye , Zhan Chao , Liu Xianbin , Cui Buli , Zeng Lin
Published: June 2024

Introduction

Sedimentary evolution and river channel changes of large river delta (e.g. Huang River, Changjiang River) in response to environmental changes have been one of the key issues in global change research.

Methods

This study reconstructed sedimentary environment changes in the modern Yellow River Delta (YRD), based on grain size and elemental chemical analysis of two short cores (YDC and YDG) from the southern region of the Qing 8 course delta of the modern YRD.

Results

The results indicated that the cores YDC and YDG sediment were dominated by silt (58.47% and 67.6%, respectively) with varied grain-size variations and poor sediment sorting. The cores YDC and YDG sediments are both predominantly composed of the major element SiO2, and have an average content of 55.53% and 58.45%, respectively. The R-mode factor analysis showed the content of chemical substances of core sediments was controlled by three factors: grain size, sedimentary provenance, and marine sedimentary dynamics.

Discussion

Before the diversion of the Yellow River to the Qing 8 course in 1996, the two cores sediment were mainly sources from the Yellow River, and both cores were in the delta-front sedimentary environment under weak hydrodynamic conditions. After the Yellow River was diverted to the Qing 8 course, the cores YDC and YDG experienced significant erosion under the nearshore strong waves and tides. And then the sedimentary environment of the YRD changed from siltation to erosion. The results of the study would be helps to further our understanding of the changes in sediment grain size and geochemical element characteristics in the Yellow River estuary, and reveal the evolution of its sedimentary environment.
Case report: Successful combination therapy with isavuconazole and amphotericin B in treatment of disseminated Candida tropicalis infection
Authors: Teng Qibei , Ye Xueshi , Wang Bei , Zhang Xinyue , Tao Zhizhi , Yin Xiufeng , Yang Qianqian
Published: June 2024

Disseminated candidiasis is a severe complication in patients with hematological malignancies who have undergone chemotherapy or hematopoietic stem cell transplantation. It has a high mortality rate. When disseminated candidiasis caused by Candida tropicalis involves either the brain or heart, the prognosis is extremely poor. Traditional methods such as cultures are limited in diagnosing disseminated candidiasis. We describe a case report of a 55-year-old man with acute myeloid leukemia who developed candidemia caused by Candida tropicalis after chemotherapy, which disseminated extensively to the heart, brain, skin, liver, spleen and kidneys. In this instance, the patient was rapidly diagnosed with candida infection by metagenomic next generation sequencing, and successfully treated with combination therapy of isavuconazole and amphotericin B. The patient continued with treatment of leukemia while simultaneously receiving antifungal therapy, and both leukemia and disseminated candidiasis were effectively controlled. This case report provides real-world experience for treatment of patients with leukemia complicated by disseminated candidiasis.
Uses of infrared thermography in acute illness: a systematic review
Authors: Stanley Sophie A. , Divall Pip , Thompson Jonathan P. , Charlton Matthew
Published: June 2024

Introduction

Infrared thermography (IRT) is a non-contact, non-ionising imaging modality, providing a visual representation of temperature distribution across a surface.

Methods

We conducted a systematic search of indexed and grey literature for studies investigating IRT applications involving patients in acute care settings. Studies were categorised and described along themes identified iteratively using narrative synthesis. Quality appraisal of included studies was performed using the Quality Assessment tool for Diagnostic Accuracy Studies.

Results

Of 1,060 unique records, 30 studies were included. These were conducted in emergency departments and intensive care units involving adult, paediatric and neonatal patients. IRT was studied for the diagnosis, monitoring or risk stratification of a wide range of individual conditions. IRT was predominantly used to display thermal change associated with localised inflammation or microcirculatory dysfunction. Existing research is largely at an early developmental stage.

Discussion

We recommend that high quality diagnostic validation studies are now required for some clinical applications. IRT has the potential to be a valuable tool in the acute care setting and represents an important area for future research particularly when combined with advances in machine learning technology.

Systematic review registration

CRD 42022327619 (https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=327619).
Odors in space
Authors: McKissick Olivia , Klimpert Nell , Ritt Jason T. , Fleischmann Alexander
Published: June 2024

As an evolutionarily ancient sense, olfaction is key to learning where to find food, shelter, mates, and important landmarks in an animal’s environment. Brain circuitry linking odor and navigation appears to be a well conserved multi-region system among mammals; the anterior olfactory nucleus, piriform cortex, entorhinal cortex, and hippocampus each represent different aspects of olfactory and spatial information. We review recent advances in our understanding of the neural circuits underlying odor-place associations, highlighting key choices of behavioral task design and neural circuit manipulations for investigating learning and memory.
Clinical meaningfulness and psychometric robustness of the MG Symptoms PRO scales in clinical trials in adults with myasthenia gravis
Authors: Regnault Antoine , Habib Ali A. , Creel Kristin , Kaminski Henry J. , Morel Thomas
Published: June 2024

Objectives

The objective of this research was to generate psychometric evidence supporting the myasthenia gravis (MG) symptoms patient-reported outcome (PRO) scales as a fit-for-purpose measure of severity of core symptoms of MG and provide information allowing their meaningful interpretation using data from a phase 3 study in MG.

Methods

Data from the MycarinG study, a phase 3 study of rozanolixizumab in patients with generalized MG who experience moderate to severe symptoms (ClinicalTrials.gov Identifier: NCT03971422) were analyzed with both classical test theory (CTT) and Rasch measurement theory (RMT). Meaningful within-individual change and group-level meaningful change were estimated for three MG Symptoms PRO scales using anchor- and distribution-based methods. Anchor-based methods used patient global impression of severity (PGIS) and change (PGIC) in MG symptoms as anchors.

Results

Good measurement properties of the MG Symptoms PRO scales were shown in the sample of 200 participants: good to excellent reliability (test–retest and internal consistency reliability) and validity (associations between items and scores within the MG Symptoms PRO scales and between the MG Symptoms PRO scores and other clinical outcomes—MG ADL, QMG score, MGC score, and MGFA classes—were as expected); and the items showed good coverage of the continuum and fit to the Rasch model. Triangulation of the anchor- and distribution-based method results led to the definition of clinically meaningful within-patient improvement in scores for Muscle Weakness Fatigability (−16.67), Physical Fatigue (−20.00), and Bulbar Muscle Weakness (−20.00), with associated ranges. Benchmarks are also proposed for the interpretation of group-level results.

Conclusion

The strong psychometric performance of the MG Symptoms PRO scales and the information generated to guide its interpretation supports its use in clinical trials for demonstrating the clinical benefits of new treatments targeting core symptoms of MG (muscle weakness fatigability, physical fatigue, bulbar muscle weakness, respiratory muscle weakness, and ocular muscle weakness).
Potential thresholds of critically increased cardiac-related spinal cord motion in degenerative cervical myelopathy
Authors: Pfender Nikolai , Jutzeler Catherine R. , Hubli Michèle , Scheuren Paulina S. , Pfyffer Dario , Zipser Carl M. , Rosner Jan , Friedl Susanne , Sutter Reto , Spirig José M. , Betz Michael , Schubert Martin , Seif Maryam , Freund Patrick , Farshad Mazda , Curt Armin , Hupp Markus
Published: June 2024

Introduction

New diagnostic techniques are a substantial research focus in degenerative cervical myelopathy (DCM). This cross-sectional study determined the significance of cardiac-related spinal cord motion and the extent of spinal stenosis as indicators of mechanical strain on the cord.

Methods

Eighty-four DCM patients underwent MRI/clinical assessments and were classified as MRI+ [T2-weighted (T2w) hyperintense lesion in MRI] or MRI− (no T2w-hyperintense lesion). Cord motion (displacement assessed by phase-contrast MRI) and spinal stenosis [adapted spinal canal occupation ratio (aSCOR)] were related to neurological (sensory/motor) and neurophysiological readouts [contact heat evoked potentials (CHEPs)] by receiver operating characteristic (ROC) analysis.

Results

MRI+ patients (N = 31; 36.9%) were more impaired compared to MRI− patients (N = 53; 63.1%) based on the modified Japanese Orthopedic Association (mJOA) subscores for upper {MRI+ [median (Interquartile range)]: 4 (4–5); MRI−: 5 (5–5); p < 0.01} and lower extremity [MRI+: 6 (6–7); MRI−: 7 (6–7); p = 0.03] motor dysfunction and the monofilament score [MRI+: 21 (18–23); MRI−: 24 (22-24); p < 0.01]. Both patient groups showed similar extent of cord motion and stenosis. Only in the MRI− group displacement identified patients with pathologic assessments [trunk/lower extremity pin prick score (T/LEPP): AUC = 0.67, p = 0.03; CHEPs: AUC = 0.73, p = 0.01]. Cord motion thresholds: T/LEPP: 1.67 mm (sensitivity 84.6%, specificity 52.5%); CHEPs: 1.96 mm (sensitivity 83.3%, specificity 65.6%). The aSCOR failed to show any relation to the clinical assessments.

Discussion

These findings affirm cord motion measurements as a promising additional biomarker to improve the clinical workup and to enable timely surgical treatment particularly in MRI− DCM patients.

Clinical trial registration

www.clinicaltrials.gov, NCT 02170155.
Germline rare variants in HER2-positive breast cancer predisposition: a systematic review and meta-analysis
Authors: de Baumont Angelica Cerveira , Cadore Nathan Araujo , Pedrotti Luana Giongo , Curzel Giovana Dallaio , Schuch Jaqueline Bohrer , Bessel Marina , Bordignon Cláudia , Rosa Mahira Lopes , Macedo Gabriel de Souza , Rosa Daniela Dornelles
Published: June 2024

Introduction

Approximately 10% of breast cancer (BC) cases result from hereditary causes. Genetic testing has been widely implemented in BC care to determine hereditary cancer syndromes and personalized medicine. Thus, identification of individuals carrying germline pathogenic variants could be useful to provide appropriate prophylactic or screening measures for each BC subtype, however, there are few formal recommendations for genetic testing in this sense so far. In this study, we assessed rare germline variants in a specific group of genes in order to determine the association with human epidermal growth factor 2 enriched (HER2+) BC phenotype through a systematic review and meta-analysis comparing subtypes overexpressing HER2 with other clinically recognized subtypes of BC. This review was registered with PROSPERO (ID: CRD42023447571).

Methods

We conducted an online literature search in PubMed (MEDLINE), Scopus, and EMBASE databases. We included original studies that investigated germline variants in HER2+ BC patients and selected the studies that reported only rare and/or pathogenic germline variants. We assessed the risk of bias and quality of the studies using the Joanna Briggs Institute Critical Appraisal checklists and the Modified Newcastle-Ottawa Scale for Genetic Studies, respectively. Considering hormone receptor and HER2 expression status, we compared gene-based risks initially in HR-HER2-, HR+HER2-, HR+HER2+, and HR-HER2+ groups, conducting separate meta-analyses using the random effects model for each comparison, and within them for each gene.

Results

Of the total 36 studies describing germline variants, 11 studies provided information on the prevalence of variants in the different clinically relevant BC subtypes and allowed comparisons. Germline variants within eight genes showed significant differences when meta-analyzed between the BC groups: BRCA1, BRCA2, TP53, ATM, CHEK2, PALB2, RAD51C, and BARD1. Notably, TP53, ATM, and CHEK2 germline variants were identified as predisposing factors for HER2+ subtypes, whereas BRCA1, BRCA2, PALB2, RAD51C, and BARD1 germline variants were associated with a predisposition to low HER2 expression. Main concerns about bias and quality assessment were the lack of confounding factors control; and comparability or outcome assessment, respectively.

Discussion

Our findings underscore the connection between germline variants and differential expression of the HER2 protein and BC subtypes.

Systematic review registration

https://www.crd.york.ac.uk/PROSPERO, identifier CRD42023447571.
Is calcium deficiency the real cause of bitter pit? A review
Authors: Torres Estanis , Kalcsits Lee , Nieto Luís Gonzalez
Published: June 2024

Bitter pit is a disorder affecting the appearance of apples. Susceptibility is genetically controlled by both the cultivar and rootstock, with both environmental and horticultural factors affecting its severity and proportional incidence. Symptoms appear more frequently at the calyx end of the fruit and consist of circular necrotic spots, which take on a “corky” appearance visible through the peel. Bitter pit may develop before harvest, or after harvest, reducing the proportions of marketable fruit. In this review, current knowledge of the factors associated with the occurrence of bitter pit in apples is summarized and discussed along with their interactions with Ca uptake and distribution to fruit. This disorder has been previously linked with localized Ca deficiencies in fruit during its development. However, these relationships are not always clear. Even with over a century of research, the precise mechanisms involved in its development are still not fully understood. Additional factors also contribute to bitter pit development, like imbalances of mineral nutrients, low concentration of auxins, high concentration of gibberellins, changes in xylem functionality, or physiological responses to abiotic stress. Bitter pit remains a complex disorder with multiple factors contributing to its development including changes at whole plant and cellular scales. Apple growers must carefully navigate these complex interactions between genetics, environment, and management decisions to minimize bitter pit in susceptible cultivars. Accordingly, management of plant nutrition, fruit crop load, and tree vigor still stands as the most important contribution to reducing bitter pit development. Even so, there will be situations where the occurrence of bitter pit will be inevitable due to cultivar and/or abiotic stress conditions.
Genome-wide characterization of the GRF transcription factors in potato (Solanum tuberosum L.) and expression analysis of StGRF genes during potato tuber dormancy and sprouting
Authors: Cui Danni , Song Yin , Jiang Weihao , Ye Han , Wang Shipeng , Yuan Li , Liu Bailin
Published: June 2024

Growth-regulating factors (GRFs) are transcription factors that play a pivotal role in plant growth and development. This study identifies 12 Solanum tuberosum GRF transcription factors (StGRFs) and analyzes their physicochemical properties, phylogenetic relationships, gene structures and gene expression patterns using bioinformatics. The StGRFs exhibit a length range of 266 to 599 amino acids, with a molecular weight of 26.02 to 64.52 kDa. The majority of StGRFs possess three introns. The promoter regions contain a plethora of cis-acting elements related to plant growth and development, as well as environmental stress and hormone response. All the members of the StGRF family contain conserved WRC and QLQ domains, with the sequences of these two conserved domain modules exhibiting high levels of conservation. Transcriptomic data indicates that StGRFs play a significant role in the growth and development of stamens, roots, young tubers, and other tissues or organs in potatoes. Furthermore, a few StGRFs exhibit differential expression patterns in response to Phytophthora infestans, chemical elicitors, heat, salt, and drought stresses, as well as multiple hormone treatments. The results of the expression analysis indicate that StGRF1, StGRF2, StGRF5, StGRF7, StGRF10 and StGRF12 are involved in the process of tuber sprouting, while StGRF4 and StGRF9 may play a role in tuber dormancy. These findings offer valuable insights that can be used to investigate the roles of StGRFs during potato tuber dormancy and sprouting.
Hungry pigeons prefer sooner rare food over later likely food or faster information
Authors: Wittek Neslihan , Sayin Berna Selin , Okur Nurdem , Wittek Kevin , Gül Naciye , Oeksuez Fatma , Güntürkün Onur , Anselme Patrick
Published: June 2024

Introduction

Making decisions and investing effort to obtain rewards may depend on various factors, such as the delay to reward, the probability of its occurrence, and the information that can be collected about it. As predicted by various theories, pigeons and other animals indeed mind these factors when deciding.

Methods

We now implemented a task in which pigeons were allowed to choose among three options and to peck at the chosen key to improve the conditions of reward delivery. Pecking more at a first color reduced the 12-s delay before food was delivered with a 33.3% chance, pecking more at a second color increased the initial 33.3% chance of food delivery but did not reduce the 12-s delay, and pecking more at a third color reduced the delay before information was provided whether the trial will be rewarded with a 33.3% chance after 12 s.

Results

Pigeons’ preference (delay vs. probability, delay vs. information, and probability vs. information), as well as their pecking effort for the chosen option, were analyzed. Our results indicate that hungry pigeons preferred to peck for delay reduction but did not work more for that option than for probability increase, which was the most profitable alternative and did not induce more pecking effort. In this task, information was the least preferred and induced the lowest level of effort. Refed pigeons showed no preference for any option but did not drastically reduce the average amounts of effort invested.

Discussion

These results are discussed in the context of species-specific ecological conditions that could constrain current foraging theories.