bluuebunny/crossref_metadata_2025 huggingface dataset:
Rol Belirsizliği ve Rol Çatışmasının İş Performansına Etkisinde İş Tatmininin Aracılık Rolü: Mersin İlinde Faaliyette Bulunan Özel Hastaneler Üzerine Bir Araştırma
Authors: ÖZBOZKURT Onur Başar , ÖZBOZKURT Neslihan
Published: August 2019

Rekabet ortamındaki işletmeler, her geçen gün
hızla değişen ve gelişen bu rekabet yarışının gerisinde kalmamak için çalışan
performansının artırılmasını arzu ederken; diğer taraftan çalışanlar,
hiyerarşiden kaynaklanan rol belirsizliği ve rol çatışması ile karşılaşırlar.
Çalışmanın temelini oluşturan özel sağlık sektöründe ise, birçok meslekten
farklı olarak kendine özgü bir yapılanma ve görev tanımı bulunmaktadır. Bu
bağlamda, araştırma için Mersin ilindeki özel hastanelerde 400 sağlık çalışanı
üzerinde anket uygulaması gerçekleştirilmiş, özel sağlık sektörü çalışanlarının
rol belirsizliği ve rol çatışmasının performanslarına etkisi ve iş tatmininin
aracılık rolü araştırılmıştır. Analiz sonucunda, rol belirsizliği ve rol
çatışmasının özel sağlık sektörü çalışanlarının performansı ile iş tatminini
olumsuz yönde etkilediği ve iş tatmininin rol belirsizliği ve rol çatışması
üzerinde aracılık rolü olup, çalışanların performansını olumlu yönde etkilediği
görülmüştür.
THE DETERMINANTS OF OUTWARD FOREIGN DIRECT INVESTMENT FROM ASEAN
Authors: Ibrahim Alisa , Driffield Nigel , Glaister Keith
Published: August 2019

Purpose  of  Study:  This study investigates the determinants of ASEAN outward foreign direct investment (OFDI) and the extent to which the four general motives of OFDI (market seeking, efficiency-seeking, resource-seeking, strategic-assets-seeking) can explain the phenomenon in the four chosen ASEAN countries (Malaysia, Singapore, Thailand and Indonesia). Methodology: We used panel data from 2001 – 2016 and the Tobit regression model to ascertain the results. We found that each country possibly has slightly different motives between each other although market seeking is seen as the general motive. As most of the previous studies focused on other developing countries such as BRICS, this study contributes to the small but growing literature of ASEAN economies. Furthermore, the usage of the Tobit regression Model helps us in explaining the variables with zero value, hence yielding a more informative result. Results: We found that, in general, some determinants were consistent with findings in the literature, while others need further investigation. Lastly, based on the findings, we can conclude that the mainstream theory of outward FDI applies to ASEAN.
A FASE INICIAL DO PROCESSO DA VIVÊNCIA COM A DOENÇA DE PARKINSON
Authors: Valcarenghi Rafaela Vivian , Alvarez Angela Maria , Nunes Simony Fabíola Lopes , Tomasi Andrelise Viana Rosa , Siewert Josiane Steil , Baptista Rafaela
Published: August 2019

Objetivos: Conhecer a vivência da pessoa com doença de Parkinson desde o surgimento dos sinais e sintomas até a confirmação do diagnóstico. Métodos: Pesquisa qualitativa, utilizando o referencial metodológico da Teoria Fundamentada nos Dados. Participaram da entrevista em profundidade 30 pessoas com doença de Parkinson, cadastradas na Associação Parkinson Santa Catarina, e, posteriormente, cinco pessoas com a doença validaram os resultados. A coleta ocorreu entre setembro de 2013 e abril de 2014. Resultados: Emergiram três categorias: Percebendo que algo está mudando em suas capacidades, Percorrendo os consultórios médicos, e Lidando com o impacto da doença. Conclusão: Foi possível conhecer a vivência das pessoas com a doença em sua fase inicial, mostrando aspectos importantes na compreensão deste processo, e a partir de tal entendimento refletir sobre práticas de cuidados a esse grupo específico, incorporando assistência qualificada a esses usuários dos serviços de saúde.
Posisi Guru sebagai Orang Tua dan Murid sebagai Anak Menurut Perspektif Al-Qur’an
Authors: Malik Muhammad Abdul
Published: August 2019

Penelitian ini bertujuan untuk menggambarkan bagaimana hubungan antara guru dan murid yang seharusnya, berdasarkan ayat-ayat yang membicarakan hubungan orang tua dengan anak dan ayat-ayat yang membicarakan tentang adab terhadap nabi. Penelitian ini merupakan penelitian kualitatif dengan menggunakan analisis deskriptif dengan landasan utama menggunakan beberapa literatur tafsir Alquran dan sebagai sumber sekunder dari literatur lain yang berhubungan dengan topik pembahasan.  Adapun sikap yang harus dilakukan guru terhadap murid adalah (1) memanggil murid denan panggilan kasih sayang, panggilan yang disenangi oleh murid (2) aktif memberikan nasihat yang positif dengan lemah lembut, dengan cara yang baik. Sedangkan bagaimana seorang murid bersikap terhadap gurunya adalah (1) menghormati gurunya dengan sebenar-benarnya karena guru juga membawa peran kenabian, yaitu sebagai muallim (2) jangan meninggikan suara di depan guru (3) banyak berterimakasih kepada guru atas jasa dan ilmu yang telah diberikan (4) tidak berkata yang tidak pantas atau membentak guru (5) bergaul dan memanggil guru dengan lembut. Diharapkan penelitian ini bisa membantu mewujudkan dunia pendidikan yang lebih baik, yang membuat guru dan murid saling menghormati demi tercapainya tujuan pendidikan nasional.
HERMENEUTICS OF NATIONALITY FIQH: STUDY OF BAHTSUL MASAIL OF LIRBOYO ALUMNI ASSOCIATION
Authors: Kholilah Iis
Published: August 2019

This article analyses the text of bahtsul masail from the alumni of Lirboyo Islamic traditional boarding school focusing on the motive behind its publication, the basic concept of nationalism proposed by the text, the dominance of legal reasoning used in the text and its potential toward the readers. By employing critical hermeneutic approach, there were three stages of analysis, i.e. socio-historical analysis, text analysis and interpretation of the text. According to the analysis this research concludes that the recent phenomenon of the rising of anti-nationalism Islamic movement led by Hizbut-Tahrir and certain radical hard-line organization since 2000s has been the main motive of the publication of the text. This text also proposes the meaning of nationalism as the intention to love the nation and country and its consequences as a Moslem in Indonesian context. Moreover Qauliyah has had been used as the main legal reasoning to formulate certain concepts and this text might be less compatible for the prospective readers outside the Santri’s community. Because many arguments from Arabic resources scattered throughout the text in which still need depth explanation for the beginners.
EXTINGUISHING FIRE, IGNITING TOLERANCE: FIRE FIGHTER COMMUNITY, CIVIL CULTURE AND TOLERANCE
Authors: Rosadi Sandi
Published: August 2019

The correlation between civil society and democracy is a big discussion in academic world. Democracy that engenders a civic culture usually linked into a tolerant behavior in society. This study aims to understand how the participation of individuals in civil society, in this case is BPK (fire fighter community) in Banjarmasin, cause them to become more tolerance in a pluralistic society. In addition, this study also examines whether the involvement of member to BPK in Banjarmasin make them as an individual who is more attentive and tolerant towards different groups or vice versa. This study argues that there is a correlation between a personal membership in civil society with their augmentation in tolerance attitude. The case of fire fighter community in Banjarmasin shows an establishment of a brotherhood among its members. The attitude of ”sanak ikam” or your brother brings up the attitude of civic members' tolerance of all the differences that exist in other individuals in general and differences in members of BPK in particular. Furthermore, on personal level, a member's attitude towards tolerance can also be affected by the diversity of members in BPK who their affiliated. However, BPK has the possibility of being a place for political contestation. On one side BPK has been playing a role in fostering tolerance in Banjarmasin society, on the other hand, it is possible in the future become a double-edged knife that even destroys the tolerance that has been formed.
Evaluation of the Technical Condition of Power Structures of Launch Complexes at the Cosmodrome Plesetsk
Authors: Ertman L.V. , Erofeev M.Y.
Published: August 2019

The article deals with the issues of inspection and evaluation of the technical condition of power metal structures of systems and units of the launch complexes at the cosmodrome Plesetsk. An analysis of specific features of operation of metal structures at the cosmodrome’s launch complexes and the main types of defects occuring in these structures is carried out. The methods and means of non-destructive testing used in the inspection of the metal structures and assemblies are described. These methods can help to identify defects at the early stages of development, plan and take timely measures to eliminate the defects and reduce the risk of sudden failures of the systems and units. The article provides practical examples of the survey results using the methods and means of non-destructive testing of metal structures of systems and units of the launch complexes 17P32 and 14P25.
In vivo and ex vivo impact of nutritional xenobiotics – acrylamide and sodium nitrates – on plasma antioxidant properties
Authors: Rorbach-Dolata Anna , Żurawska-Płaksej Ewa , Marchewka Zofia , Piwowar Agnieszka
Published: August 2019

Wstęp

Grupy tiolowe (SH) obecne w osoczu krwi odgrywają ważną rolę w oksydacyjno-antyoksydacyjnej homeostazie organizmu. Są one podatne na niekorzystne działanie różnych czynników egzo- i endogennych. Szczególnie istotnym problemem jest długotrwałe narażenie na różne ksenobiotyki, np. związki zawierające azot, powszechnie występujące w żywności. Celem naszych badań była ocena wpływu akrylamidu (acrylamide – ACR) i azotanu sodu (sodium nitrate – SN) – (V) i (III) – na właściwości przeciwutleniające osocza poprzez pomiar stężenia grup SH.

Materiał i metody

Stężenie grup SH w osoczu uzyskanym od 62 młodych osób (model in vivo; czas t0) oraz w próbkach poddanych godzinnej inkubacji z odpowiednim stężeniem ACR i SN (III) (model ex vivo; czas t1) mierzono metodą Ellmana. Stężenia ACR i SN (III) w modelu ex vivo odpowiadały ich dziennemu spożyciu (odpowiednio DIA – daily intake of acrylamide – i DIN – daily intake of sodium nitrates (V) i (III)), oszacowanemu na podstawie kwestionariusza żywieniowego.

Wyniki

W obu modelach akrylamid i azotany spowodowały znaczny spadek stężenia grup SH, ale ACR spowodował silniejsze zmiany. Kobiety spożywały większą ilość związków zawierających azot w porównaniu z mężczyznami, prawdopodobnie z powodu odmiennych nawyków żywieniowych.

Wnioski

Uzyskane wyniki wskazują, że ksenobiotyki zawierające azot są ważnymi czynnikami obniżającymi potencjał antyoksydacyjny osocza, a ich spożycie powinno być kontrolowane.
PENGARUH PENERAPAN MODEL PEMBELAJARAN TIPE TWO STAY TWO STRAY (TSTS) TERHADAP MOTIVASI BELAJAR SISWA KELAS VII PADA MATERI KLASIFIKASI MAKHLUK HIDUP
Authors: Apriani Wilia , Syarifah Syarifah , Abdurrahmansyah Abdurrahmansyah
Published: August 2019

Motivation as one of the psychological factors in the learning process has meaning as a whole driving force within the students that lead to learning activities. The existence of diligent efforts and especially based on motivation, then someone who learn will be able to get a good achievement. The purpose of this study is to improve students' learning motivation of VII class on science subjects of Living Classification Classification in Junor High School by using Two Stay Two Stray (TSTS) cooperative learning model. This research is descriptive-quantitative method by using Quasy experiment. The design that used is Posttest Only-Control Design. The population in this study were all students of VII class in MTs Lahat and the sample was VII.1 class as control class and VII. 5 as experimental class. The results of the research through direct observation by using the observation sheet proves that there is an increase in learning motivation of learners in following the learning through cooperative learning model type Two Stay Stray (TSTS) from the first meeting until the third meeting. It can be seen from the questionnaire that is calculated by using t-test for see the influence of cooperative learning model type Two Stay Two Stray (TSTS) to student learning motivation. The result is tarithmetic˃ ttable or 7,56˃1,9983. This shows that H0 is rejected and Ha is accepted. It can be concluded that there is influence of the application of cooperative learning model type Two Stay Two Stray (TSTS) to student's learning motivation.
PENGARUH METODE PEMBELAJARAN BRAINSTORMING TERHADAP KETERAMPILAN BERPIKIR KREATIF PADA MATERI VIRUS KELAS X DI SMA NEGERI 1 PLAKAT TINGGI
Authors: Riswanda Jhon , Nawawi Sulton , Setiawan Dadang
Published: August 2019

This study aims to determine the effect of Brainstorming learning method influence on creative thinking skills on Class X Virus material in SMA N 1 Plakat Tinggi MUBA Regency. This research uses the design of Nonequivalent Control Group Design research with Quasi Experiment method. The sample of this research is 78 students. Based on the results of data analysis students' creative thinking skills show that the implementation of learning using Brainstorming learning method is better than conventional methods. This can be seen from the calculation of t-test sig titung 0.000 < 0.005, then Ha accepted and Ho rejected. The result of analysis of the average increase of mastery of experimental creative thinking skill is 87.4% while the students 'thinking skill in the control class is 77.4% meaning that the students' creative thinking skill is higher than the creative thinking skill of the control class. So, it can be concluded that the method of Brainstorming influence the creative thinking skills of students class X MIPA SMA N1 Plakat Tinggi MUBA regency.
PERBEDAAN KEMAMPUAN BERPIKIR KRITIS LAKI-LAKI DAN PEREMPUAN PADA MATERI SISTEM PEREDARAN DARAH MATA PELAJARAN BIOLOGI KELAS XI MIPA MAN I BANYUASIN III
Authors: Yanti Erna Dwi , Wigati Indah , Habisukan Ummi Hiras
Published: August 2019

The ability of critical thinking is very important to have. If the students have an ability of critical thinking, they students can solve the problems that facing them on the lesson study especially biology. Based on that problem, the writer was conducted a research which have the aim to know the difference between the ability of male students’ and female students’ critical thinking on blood circulation system material in biology lesson of XI MIPA MAN 1 Banyuasin. This research was conducted on july 17, 2018 At XI MIPA class of MAN 1 Banyuasin. This research was descriptive analysis research. The subject of this research was the students of XI MIPA 1, XI MIPA 2, XI MIPA 3 XI MIPA 4 of MAN 1 Banyuasin with the total of the students are 157 students. Data analyzing technique used probability sampling technique that is proportionate stratified random sampling with descriptive analysis method, the result of this research showed that the ability of male students’ critical thinking are low with the average 13.15. The ability of female students’ critical thinking are high with the average 14.05. There is the difference between the ability of male studets’ and female students’ critical thinking. In conclusion, the ability of female students’ critical thinking is higher than male student’s in MAN 1 Banyuasin.
Implementasi Metode Fast Dalam Rancang Bangun Sistem Informasi Keuangan Pada Perguruan Tinggi Widya Dharma Palembang
Authors: Astuti Novia Wasfriyani , Kadafi Muhamad , Muhammadinah Muhammadinah
Published: August 2019

Proses transaksi keuangan dari penerimaan dan pengeluaran kas yang masih dilakukan secara manual yaitu menggunakan buku besar dan hanya berupa print out yang diketik di Microsoft Word, menyulitkan bendahara ketika melakukan transaksi pembayaran ke mahasiswa dan pembuatan laporan ke pimpinan. Maka, diperlukan sebuah sistem yang dapat membantu dalam pengolahan keuangan dari penerimaan dan pengeluaran kas tersebut. Dengan menggunakan metode analisis dan desain FAST (framework for the application of system thinking) serta metode pengembangan sistem RAD (Rapid application development) penulis melakukan penelitian untuk membangun Sistem informasi keuangan pada perguruan tinggi Widya Dharma Palembang berbasis web. Secara garis besar, sistem ini berfungsi untuk mempermudah proses pencatatan pembayaran mahasiswa, proses pencarian sisa pembayaran mahasiswa, serta mempermudah ketua dalam mengetahui laporan keuangan mengenai transaksi dari penerimaan dan pengeluaran kas.
Sistem Informasi Order Makanan dan Booking Tempat Berbasis Mobile Android Menggunakan Protokol JSON
Authors: Syafrizal Dodi , Wijaya Freddy Kurnia , Kadafi Muhamad
Published: August 2019

Aktivitas manusia yang terus meningkat dan telah menyita waktu menuntut banyak restoran atau rumah makan untuk menyediakan layanan pemesanan makanan dan booking tempat secara online dan praktis. Pelayanan yang lambat dan kurang akurat akan sangat mempengaruhi kualitas dari restoran tersebut. Tujuan penelitian ini adalah membuat Sistem Informasi Order Makanan Dan Booking Tempat Berbasis Mobile Android Menggunakan Protokol JSON, yang dapat mengelola data rumah makan, data pelanggan, data menu makanan, data transaksi pemesanan dan data booking tempat menggunakan metode penelitian waterfall. Tahapan pada metodologi waterfall antara lain communication, planning, modeling, construction dan deployment. Dari penelitian yang telah peneliti lakukan pada rumah makan atau restoran-restoran tersebut maka menghasilkan suatu informasi transaksi order makanan dan booking tempat melalui mobile android. Adapun setiap bagian pengelola dapat merekap seluruh data-data rumah makan maupun data keuangan untuk bagian kasir, dan data rekapitulasi seluruh pemesanan untuk bagian pemilik rumah makan.
Modelling Temperature Variation of Mushroom Growing Hall Using Artificial Neural Networks
Authors: Ardabili Sina , Mosavi Amir , Mahmoudi Asghar , Gundoshmian Tarahom Mesri , Nosratabadi Saeed , Varkonyi-Koczy Annamaria R.
Published: August 2019

Recent advancements of computer and electronic systems have motivated the extensive use of intelligent systems for automation of agricultural industries. In this study, the temperature variation of the mushroom growing room is modeled through using a multi-layered perceptron (MLP) and radial basis function networks. Modeling has been done based on the independent parameters including ambient temperature, water temperature, fresh air and circulation air dampers, and water tap. According to the obtained results from the networks, the best network for MLP is found to be the second repetition with 12 neurons in the hidden layer and 20 neurons in the hidden layer for radial basis function networks. The obtained results from comparative parameters for two networks showed the highest correlation coefficient (0.966), the lowest root mean square error (RMSE) (0.787) and the lowest mean absolute error (MAE) (0.02746) for radial basis function. Therefore, the neural networks with radial basis function was selected as the optimal predictor for the behavior of the system.
Simulation the Probability of Liberalizing Chlorin Gas from Urban Water Chlorination System in Alborz: With the Cancer Approach
Authors: Yari Saeed , Yari Saeed , Saeedabadi Hamzeh , Yari Saeed
Published: August 2019

Background: Qazvin province has suffered a lot of natural disasters (earthquakes) for a long time. so, the establishment of the first industrial city in Iran, has always been a source of concern. One of these problems is the possibility of chlorine gas leaking from the chlorination system of drinking water and treatment plant the existing ones are on the health of the inhabitants of this region.Material and method: This analytical study was carried out in Novorossiysk district of Alborz in December 2012. Initially, chlorine gas leakage scenarios from these facilities were simulated by ALOHA and WISER software, and then using the Emergency Level System, according to the CCPS Consultative Center's Chemical Process Safety Advice, the Emergency Response Program was presented. Results: ALOHA software, in comparison with WISER software, has more precision to identify and address the consequences of chlorine gas leakage hazards and according to the simulation of this software in the event of a leak from the well and water resources unit at 8240 m from the area and at night 7520 meters will be affected. Due to the speed of delivering results through the WISER software, this software can be used at times when the operating speed is considered (incident time).Conclusion: According to the CCPS model, the emergency conditions were classified at levels 3 and 4, therefore, the relevant crisis management agencies (Qazvin Crisis Management Committee, Alborz City Health Center, Red Crescent and Firefighting Authority) should provide training maneuvers At Alborz city level, and informing people of cities and industrial companies, many efforts have been made to reduce human and environmental damage in case of possible leakage.
Unified Degenerate Central Bell Polynomials
Authors: Acikgoz Mehmet , Duran Ugur
Published: August 2019

In this paper, we firstly consider extended degenerate central factorial numbers of the second kind and provide some properties of them. We then introduce unified degenerate central Bell polynomials and numbers and investigate many relations and formulas including summation formula, explicit formula and derivative property. Moreover, we derive several correlations for the fully degenerate central Bell polynomials associated with the degenerate Bernstein polynomials and the degenerate Bernoulli, Euler and Genocchi numbers.
Effects of Pet Insects on Cognitive Function Among the Elderly: An fMRI Study
Authors: Park Ji-Yeon , Ko Hae-Jin , Kim A-Sol , Moon Ha-Na , Choi Hye-In , Kim Jin-Hee , Chang Yongmin , Kim Seong-Hyun
Published: August 2019

Background: Animal-assisted therapy has positive effects on cognitive function, depression, performance ability, and social functioning in elderly patients. The aim of this study was to evaluate the effects of rearing pet insects on the cognitive function of healthy elderly participants, with fMRI (functional magnetic resonance imaging) being used for this purpose. Methods: Community-dwelling elderly women (≥60 years) with normal cognitive function were enrolled during April 2015. They were randomized at a 1:1 ratio into two groups: insect-rearing and control (n=16) groups, with the insect-rearing group being further classified into two groups for analysis according to the subjects’ scores in the Wisconsin Card Sorting Test, WCST) at the first fMRI: insect-rearing group I with a relatively high score (n=13), and insect-rearing group II with a relatively low score (n=6). All subjects were educated on a healthy lifestyle for better cognitive function at every visit, and the insect-rearing groups received and reared crickets as pet insects. The fMRI was performed at baseline and after 8 weeks using the WCST as a stimulus. The WCST consisted of two variations, a high level baseline (HLB) and semi-WCST version. Results: There were no significant differences in the baseline characteristics among the three groups. There was a significant difference accuracy of the HLB–semi-WCST (p<0.05) in insect-rearing group II after 8 weeks from the baseline test. In the fMRI analysis involving the WCST reaction test, increased activation was observed in the right dorsal lateral prefrontal cortex and parietal cortex in insect-rearing group II when the semi-WCST, rather than the HLB, was performed. There were no significant differences in the other groups. Conclusion: The rearing of pet insects as an animal-assisted therapy is cost-effective, easy, and occupies little space. In this study, it showed positive effects on executive functions and performance improvement in elderly women. Further larger studies on the effects of pet insects on cognitive function are warranted.
Pengembangan Multimedia Interaktif Pengenalan Salat untuk Meningkatkan Aspek Perkembangan Anak Usia Dini
Authors: Marlisa Lusi , Purnama Sigit
Published: August 2019

The aims of the reaserch was: (1) to know how the development of interactive multimedia in praying introduction; (2) to know the effectiveness of the use of interactive multimedia the introduction of prayer for aspects of  child development in integrated isamic kindergarten Mutiara Banguntapan, Bantul Yogyakarta. The method that used in this research was Research and Development (R&D) R&D used for measuring the feasibility of interactive multimedia product by refering to development style of Borg & Gall through 6 stages of development, namely: (1) potential and problem; (2) data collection; (3) design product; (4) validation product; (5) revision product; (6) trials product. The result of the research showed that: (1) interactive multimedia of prayer introduction was developed based on the development prosedure Borg and Gall. The appropriateness of product based on the validation of media experts and material experts with an overall rating of 3.83 in the good category. So that, can be concluded that multimedia developed was suitable to use in the learning media of prayer introduction, then; (2) Application of multimedia interactive prayer performed on 15 child in the class A2 abu sufyan bin harist, by conducting experimental trials by looking at the effectiveness of the use of interactive multimedia introduction of pre and post prayers on aspects of child development. Average effectiveness before use interactive multimedia introduction prayer on aspects child development 36,54% and Average effectiveness after use interactive multimedia introduction prayer on aspects child development 76,66% with motoric physical development 73,33%,  language 80%, cognitive 80%, social emotional 73,33%. So it can be concluded that by using interactive multimedia the introduction of prayer to aspects of development is more effective than not using interactive multimedia recognition of prayer on aspects of development.
Pneumococcal serotypes in children and relationship with clinical presentation and antimicrobial susceptibility in the PCV13 era
Authors: Izquierdo Conchita , Ciruela Pilar , Hernandez Sergi , García Juan Jose , Esteve Cristina , Moraga Fernando , Diaz Alvaro , Osorio Johanna Martínez - , Solé-Ribalta Anna , Sevilla Mariona Fernandez de , Gonzàlez-Peris Sebastian , Codina Gemma , Planes Anna Maria , Uriona Sonia , Campins Magda , Muñoz Carmen , Salleras Lluis , Domínguez Angela
Published: August 2019

Background: The aim of this study was to analyse the serotypes causing invasive pneumococcal disease (IPD) according to the clinical presentation, and antimicrobial susceptibility in children aged ≤17 years before the introduction of the 13-valent pneumococcal conjugate vaccine (PCV13) in the official paediatric schedule.
Methods: We conducted a prospective study in children ≤17 years with IPD attended in three Catalan hospitals between January 2012 and June 2016. IPD cases were diagnosed by culture or RT-PCR. Demographic, microbiological, and clinical data were analysed. Associations were assessed using the odds ratio (OR) and 95% confidence intervals (CI).
Results: Of the 253 cases included, 34.4% were aged < 2 years, 38.7% 2-4 years and 26.9% 5-17 years. Over 64% of cases were PCV13 serotypes. Cases with PCV13 serotypes were associated with overall pneumonia (OR:7.47[4.0-13.96]) and complicated pneumonia (OR:7.2[4.04-12.75]), overall and in each age group (p<0.05). Serotypes 3 and 1 were associated with complicated pneumonia (p<0.05). Non-PCV13 serotypes were associated with meningitis (OR:7.32[2.33-22. 99]) and occult bacteremia (OR:3.6[1.56-8.76]). Serotype 19A was more frequent in children aged <2 years and serotype 3 and 1 in those aged 2-4 years and >4 years, respectively. Forty-four cases (36.1%) were non-susceptible to penicillin and 16.4% were also non-susceptible to cefotaxime. There were no significant differences between PCV13 and non-PCV13 cases with non-susceptible penicillin strains (36.1% and 36.0%, respectively), while PCV13 cases showed more frequently non-susceptible cefotaxime strains (23.6%; p=0.010). Serotypes 19A and 14 were associated with non-susceptibility to both penicillin and cefotaxime strains (p=0.003 and p<0.001, respectively) and serotype 19A with resistant to penicillin (p=0.002)
Conclusions: PCV13 serotypes were the most frequent serotypes in children aged ≤17years, mainly serotype 3, 1 and 19A. Non-PCV13 serotypes were associated with meningitis and occult bacteraemia while PCV13 serotypes with pneumonia. PCV13 and non-PCV13 cases presented high frequency of non-susceptibility to penicillin. Serotypes 19A, and 14 were associated with non-susceptibility to both penicillin and cefotaxime, and serotype19A with penicillin resistance.
Transcriptome analysis provides insights into the non-methylated lignin synthesis in Paphiopedilum armeniacum seed
Authors: fang lin , Xu Xin , Li Ji , Zheng Feng , Li Mingzhi , Yan Jingwei , Li Yuan , Zhang Xinhua , Li Lin , Ma Guohua , Zhang Aying , Lv Fubin , Wu Kunlin , Zeng Songjun
Published: August 2019

Abstract

Backgrounds
Paphiopedilum is an important genus of orchid family (Orchidaceae) with high horticultural value. The wild populations are under the threat of extinction because of over collection and habitat destruction. Mature seeds of most Paphiopedilum species are difficult to germinate, which severely restricts the germplasm resources protection and commercial production. The germination inhibition factors are largely unknown.
Results
In this study, we found large amounts of non-methylated lignin were accumulated during seed maturation of Paphiopedilum armeniacum (P. armeniacum), which negatively correlates with the germination rate. We then further compared the transcriptome profiles of P. armeniacum seed at different development stages to explore molecular clues for the non-methylated lignin synthesis. KEGG enrichment analysis showed that a large number of genes associated with phenylpropanoid biosynthesis and phenylalanine metabolism as the seed maturation were differentially expressed. Several key genes in the lignin biosynthetic pathways displayed different expression patterns during the lignification process. PAL, 4CL, HCT and CSE were up-regulated to accelerate the C and H lignin accumulation. The expression of CCoAOMT, F5H and COMT were maintained at a low level or down-regulated to inhibit the conversion to the typical G and S lignin. Quantitative real-time RT-PCR analysis confirmed the altered expression levels of these genes among seeds and vegetative tissues.
Conclusions
This work demonstrated the plasticity of natural lignin polymer assembly in seed, and provided a better understanding of the molecular mechanism of seed-specific lignification process.
Investigation and Analysis of Standardized Training for Residents of General Practitioners of Gansu Province in China
Authors: Cai Hui , Wang Hongjing , He Jin , Zhang Dongzhi , Wu Yue , Wang Peidong
Published: August 2019

Background: China’s standardized training for residents of general practitioners (GPs) is aimed at providing the postgraduate training to family physicians who will serve the primary medicine units. The aim of this paper is to investigate the standardized training situation, satisfaction of standardized training, work situation and intention, satisfaction of work and attitude for GPs who have finished standardized training.
Methods: This study was undertaken among 6 training hospitals of Gansu province. The survey included a questionnaire with 73 queries.
Results: Approximately 275 residents of GPs were approached. In total, 263 residents participated (95.64% response rate). The average age of the participants was 28 years (standard deviation, 1.93 years; range, 25-36 years). The gender distribution was 50.57% women and 49.43% men. Marital status was 56.65% single and 43.35% married. In the results, 92.40% residents had obtained certification of the standardized training for residents of GPs. Only 39.54% residents were satisfied for monthly income during the training. And among 171 rural medical oriented graduates, only 42.69% residents wanted to continue to work at the grass-roots level when the serve time 6 years was finished. 86.31% residents of GPs who had finished the standardized training had jobs. More than half of medical institutions were belong to the primary medical and health institutions. Only 29.96% residents were registered as GPs. And the main reason for not been registered as GPs was that the medical institutions and sanitary bureau did not know the general medicine policy and did not agree. Among the residents who were assigned in general practice department, 68.42% of the work was diagnosis and treatment of common disease and frequently-occurring diseases and the referral of patients. The percentage of residents who were satisfied for the job and income were 30.40% and 14.98% respectively.
Conclusion: China’s standardized training for residents of GPs is under gradual improvement and development. In order to cultivate more GPs and let more GPs be willing to serve the grass-roots level, formulating and executing more good policy for GPs and increasing the publicity of general medicine and GPs are necessary.
Impact of postprocedural permanent pacemaker implantation on clinical outcomes after transcatheter aortic valve replacement: A systematic review and meta-analysis
Authors: Xi Ziwei , Liu Tong , Liang Jing , Zhou Yujie , Liu Wei
Published: August 2019

Background: The incidence of conduction disturbances requiring permanent pacemaker (PPM) implantation following transcatheter aortic valve replacement (TAVR) have remained a common concern. The purpose of this study was to evaluate the impact of postprocedural PPM implantation following TAVR on clinical outcomes.
Methods: We performed a systematic search in PubMed and EMBASE databases for studies that reported raw data on clinical outcomes of patients with and without PPM implantation after TAVR and followed up patients for 10 months or longer. The primary endpoint was all-cause death. The secondary endpoints were cardiovascular death, heart failure and a composite of stroke and myocardial infarction (MI).
Results: Data from 20 studies with a total of 21666 patients undergoing TAVR, of whom 12.5% required PPM implantation after intervention, were analysed and the mean duration follow-up was 16.9 months. The rate of PPM ranged from 6.2% to 32.8% among different studies. A total of 6753 (31.2%) patients underwent TAVR with self-expandable prosthesis and 14913 (68.8%) with balloon-expandable prosthesis. The incidence of postprocedural PPM implantation was higher with the self-expandable prosthesis (n=1717, 25.4%) compared with the balloon-expandable prosthesis (n=996, 6.7%). PPM after TAVR was associated with a higher risk of all-cause death (RR: 1.13; 95% CI: 1.01-1.25; P=0.03) but not incidence of stroke and MI (RR: 0.85; 95% CI: 0.64-1.13; P=0.27).
Conclusions: In patients undergoing TAVR, the PPM implantation after intervention was associated higher all-cause mortality but not cardiovascular mortality, heart failure and stroke or MI, which remain an unsolved issue of TAVR.
A comparative study of Long Interspersed Element-1 Protein Immunoreactivity in Cutaneous Malignancies
Authors: Zolfaghari Mohammad Ali , Karimi Abbas , Kalantari Elham , Korourian Alireza , Ghanadan Alireza , Kamyab Kambiz , Esmaili Nafiseh , Razavi Amir Nader Emami , Madjd Zahra
Published: August 2019

Abstract
Background
Skin cancer is the most common cancer worldwide and commonly classified into malignant melanoma (MM) and Nonmelanoma skin cancers (NMSCs), which mainly include basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The extent to which Long Interspersed Element-1 (LINE-1, L1) ORF1p is expressed in cutaneous malignancies remains to be evaluated. The aim of this study was to assess LINE-1 ORF1p immunoreactivity in various skin cancer subtypes.
Method
The expression level of LINE-1 ORF1p was evaluated in 95 skin cancer specimens comprising 36 (37.9%) BCC, 28 (29.5%) SCC, and 31 (32.6%) melanoma using the tissue microarray (TMA) technique. Then the association between expression of LINE-1 encoded protein and clinicopathological parameters were analyzed.
Results
We showed that LINE-1 ORF1p expression level was substantially higher in BCC and SCC patients compared with melanoma samples (p < 0.001). BCC cases had higher LINE-1staining intensity scores compared with SCC cases (p = 0.004). In SCC samples lower level of LINE-1 ORF1p expression was associated with age lower than the mean (p = 0.041), while no significant correlation was found between LINE-1 ORF1p expression and other clinicopathological parameters (all p>0.05).
Conclusion : According to our observation, LINE-1 ORF1p immunoreactivity in various skin tumor subtypes extends previous studies of LINE-1 expression in different cancers. LINE-1ORF1p overexpression in NMSCs compared with MM can be considered with caution as a tumor-specific antigen for NMSCs.
Keywords: Skin Neoplasms; Retroelements; LINE-1 ORF1p; Immunohistochemistry; Tissue microarray; Biomarker
Exosomal miR-1290 promotes angiogenesis in hepatocellular carcinoma via targeting SMEK1
Authors: Wang Qiong , Wang Guanwen , Niu Lianjie , Zhao Shaorong , Li Jianjun , Zhang Zhen , Jiang Huimin , Zhang Quansheng , Wang Hang , Sun Peiqing , Yang Shuang , Xiang Rong
Published: August 2019

Abstract
Background: Hepatocellular carcinoma (HCC), the most common primary liver cancer, rely on the formation of new blood vessel for growth and frequent intrahepatic and extrahepatic metastasis. Therefore, it is important to explore the underlying molecular mechanisms of tumor angiogenesis of HCC. Recently, microRNAs have been shown to modulate angiogenic processes by modulating the expression of critical angiogenic factors. However, the potential roles of tumor-derived exosomal microRNAs in regulating tumor angiogenesis remain to be elucidated.
Methods: MiRNome sequencing was performed to uncover the miRNAs that are dysregulated in HCC patient serum-derived exosomes. Expression levels of miR-1290 in tissues and cells were determined by quantitative real-time PCR. The effect of mir-1290 on proliferation was evaluated by CCK-8 assay. The angiogenic ability of cells were determined by transwell, wound-healing, tube formation and matrigel plug assays. SMMC-7721 xenograft tumor model was established in NOD-SCID nude mice using miR-1290 and NC antagomirs to determin the angiogenic effect of mir-1290 in vivo. Target protein expression was determined by western blotting. Dual luciferase reporter assay was performed to confirm the action of miR-1290 on downstream target genes including SMEK1. Results are reported as means ± S.D. and differences were tested for significance using 2-sided Student’s t-test.
Results: In this study, our miRNome sequencing demonstrated that miR-1290 was overexpressed in HCC patient serum-derived exosomes, and we found that delivery of miR-1290 into human endothelial cells enhanced their angiogenic ability. Our results further revealed that SMEK1 is a direct target of miR-1290 in endothelial cells. MiR-1290 exerted its pro-angiogenic function, at least in part, by inhibiting the VEGFR2 signaling pathway in a SMEK1-dependent manner.
Conclusions: Collectively, our findings provide evidence that miR-1290 is overexpressed in HCC and promotes tumor angiogenesis via exosomal secretion, implicating its potential role as a therapeutic target for HCC.
Is the effect of Decitabine limited to hypomethylation and DNMTs?
Authors: Dalvand Sina , Namdari Amin , Alemi Ashraf , Meshkibaf Mohammad Hassan , Setayesh Sam , Karamallah Mojtaba Haghi , Farrokhifar Mohammad
Published: August 2019

Background: Histone modifications play a crucial role in chromatin structure. Among enzymes, which regulate these processes, histone deacetylases (HDACs) can remove acetyl groups from histone tails, thus increasing their interaction with DNA and leading to chromatin condensation. 5-Aza-2′-deoxycytidine (AZad) or Decitabine is a potent hypomethylating agent that incorporates into DNA and traps DNA methyltransferase in the form of a covalent protein–DNA adduct. Azad, not only change the gene expression through demethylation of the gene's promoter, but it also can change gene expression independently from DNA demethylation. So, the present study was to distinguish whether AZad in addition to inhibitory effects on DNA methyltransferase, can change HDAC3 and HDAC7 mRNA expression in NALM-6, HL-60 cancer cell lines.
Methods: HL-60, NALM-6 and normal cells were cultured, and the treatment dose of the AZad was obtained (1µM) by the MTT test. Finally, HDAC3 and HDAC7 mRNA expression were measured by Real Time PCR in HL-60 and NALM-6 cancerous cells before and after treatment. In addition, HDAC3 and HDAC7 mRNA expression in un-treated HL-60 and NALM-6 cancerous cells were compared to the normal cells.
Results: Our result revealed that expression of HDAC3 and HDAC7, in HL-60 and NALM-6 cells increases as compared to normal cells. After treatment of HL-60 and NALM-6 cells with AZad, HDAC3 and HDAC7 mRNA expression were decreased significantly.
Conclusions: Our data showed, the effects of AZad are not limited to direct hypomethylation of DNMTs but it can indirectly affect other epigenetic factors, such as HDACs activity, through converging pathways.
Keywords: HDAC3 ; HDAC7 ; HL-60; NALM-6 ; Decitabine ; AZad
Can we perform adjuvant chemotherapy alone in stage IB/IIA cervical cancer meeting Sedlis criteria?
Authors: Li Meng , Gu Ying , Zheng Yawen , Yang Xiaohang , Cui Baoxia , Wu Bin , Yang Xingsheng
Published: August 2019

Background: The aim of this study was to evaluate the effectiveness of chemotherapy alone as postsurgical adjuvant therapy on survival of patients in stage IB/IIA cervical squamous cell carcinoma meeting Sedlis criteria.
Methods: We retrospectively reviewed the records of 127 patients satisfying Sedlis criteria after radical surgery for stage IB/IIA cervical cancer from January 2009 to December 2013. Of these, 65 patients received radiotherapy (RT)/chemoradiotherapy (CRT), 62 patients received chemotherapy (CT) alone. Both the treatment modalities were compared on 5-year overall survival (OS), disease-specific survival (DSS), recurrence rates and side effects.
Results: Median follow-up time for surviving patients was 75 months. The 5-year OS was similar in both the groups with 85.5% in the CT and 87.7% in the RT/CRT group, respectively, (p=0.727). Likewise, there was no significant difference in 5-year DSS between the two arms (CT: 87.1% vs. RT/CRT: 90.8%; P=0.548). Rate and the pattern of recurrence were not different between the groups. Acute toxicity was more frequent in the CT group, but was statistically insignificant (P>0.05). The incidences of urinary disturbance (P=0.003) and lymphedema (P=0.041) were fewer in the CT group.
Conclusions: Adjuvant CT alone for early-stage cervical cancer patients who meet the Sedlis criteria might be a good alternative to RT/CRT.
Prognostic value of pretreatment D-dimer level in small-cell lung cancer: a meta-analysis
Authors: Wang Yan , Li Jialong , Wu Yanming , Li Jue , Che Guowei
Published: August 2019

Purpose To determine the prognostic significance of pretreatment D-dimer level in predicting clinical outcomes, such as the overall survival (OS) and progression-free survival (PFS), of patients with small cell lung cancer (SCLC).
Methods A systematic search in PubMed, Web of Science, EMBASE, Cochrane Library, CNKI, SinoMed, Wanfang and VIP databases was performed to identify available studies. The pooled hazard ratios (HRs) with 95% confidence intervals (CIs) were applied to assess the association of pretreatment D-dimer level with prognosis of SCLC patients. All statistical analyses were conducted via the STATA 12.0 version software.
Results A total of 7 studies involving 964 patients were included in this meta-analysis and all patients were from China. The results showed that elevated pretreatment D-dimer level was significantly correlated with worse OS(HR=1.90, 95% CI: 1.55-2.34, P <0.001) and PFS (HR=1.52, 95% CI: 1.24-1.85, P ＜0.001). Subgroup analyses based on the treatment, D-dimer cut-off, detection method and source of HR were also performed to further verify the prognostic value of pretreatment D-dimer level in SCLC.
Conclusions Pretreatment blood concentration of D-dimer may deserve as a reliable factor to predict prognosis of Chinese patients with SCLC. More well-designed prospective studies with big samples are still needed to verify our findings.
Mortality among cancer patients within 90 days of therapy in a tertiary hospital of Tanzania: is our pre therapy screening effective?
Authors: Changalucha Marygoreth J , Mushi MARTHA F. , Kabangila Rodrick , Silago Vitus , Likonda Beda , Mshana Stephen E.
Published: August 2019

Background

A high mortality has been reported during the first ninety days of cancer therapy and is more pronounced in patients with febrile neutropenia. Bugando Medical Center, oncology department offers cancer diagnosis and treatment services to the population of lake-zone of Tanzania with limited data on the 90 days outcome. Here, we report the 90 days mortality and factors associated with it among cancer patients attending oncology department of the tertiary hospital in Tanzania.

Methodology

Enrolled participants underwent baseline physical examinations and functional status assessment using Karnofsky score. On each clinic visit, FBP was taken and patients were investigated for infections. Data were entered in Microsoft Excel and analyzed using STATA version 13.

Results

A total of 102 participants were enrolled. Their median age was 50 years [38-60]. The majority of study participants were females 76(75%) and 82(80.4%) had primary school education. The majority of patients had solid cancer 96(94.1%). A total of 12 (11.8%) patients died within 90 days of starting therapy. Having low hemoglobin level before starting cancer therapy (p=0.001), having Karnofsky score below 80% (p=0.001) and using 5-fluorouracil containing therapy (p=0.004) were found to be associated with mortality within 90 days of therapy among cancer patients.

Conclusion

About 10% of cancer patients die within 90 days of therapy. Anemic patients, with poor performance status and on 5-Fluorouracil regimen are more likely to die within 90 days of cancer therapy.
The Response of Second Line Chemotherapy Platinum Resistant Ovarian Cancer in Sudan: 2013-2017
Authors: Alshykh Mohammed Altyb , Essa Mohammed Elmujtba Adam , Suleiman Yousra Abdelmoniem , Osman Sherihan Mohammed Elkundi , Hussein Mustafa Mohamed Ali , Mohamed Sadia Kamal Albadawi , Abdelrahim Shiemaa Emad , Osman Leena Habeeb Allah , Mohamed Saja Hassan , Rahama Salma Ismaeel , Ali Saneyya Alsir , Abdullahi Sadiya Aminu , Musa Suha Abdallah , Ahmed Abdelkareem A.
Published: August 2019

Background

Ovarian carcinoma is the fifth leading cause of cancer death worldwide. The tumor mostly associated with variant factors such as advance age, early menstruation and gene association. We aimed to highlight the effectiveness of the second line chemotherapy in the management of ovarian cancer patients in Sudan.Methods

The data were collected from the hospital patient’s records for five years period of time, included 62 patients with ovarian cancer who is treated by the second line platinum resistant chemotherapy.Result

The peak prevalence of the patients was found in Al-Gazeera state, and the least in Al-Gadarif state. Age group above 55 years was the most affected group. The vast majority of patients showed partially mass disappearing, completes and continue growing tumor respectively. All patients received variant cycles of chemotherapy as fellow 3, 6, 2, 4, 5, 1 cycle respectively. 79.4% of the patients had achieved the normal value of cancer antigen 125 (CA125) levels after the treatment. In 50% of patients the cancer recurred after 1-2 months, 32.2% after 3-4 months and 17.8% after 5-6 months. The serous adenocarcinoma was found to be the most histological type in all the patients and the least two types were observed are cell carcinoma and serous papillary.Conclusion

Our findings suggested that, Al-Gazeera state citizens were more vulnerable to resist the first line chemotherapy than others. The Sudanese patients with ovarian cancer may have better response to Gemzar.