bluuebunny/crossref_metadata_2025 huggingface dataset:
Participation in parental group support offered by the Child Health Service in Sweden: A qualitative study
Authors: Kristiansson Susanne Olsson , Wijk Sofia , Alsén Pia
Published: March 2018

All new parents in Sweden are invited to participate in parent groups by the Child Health Service (CHS), but not all choose to attend. The aim of this study was to identify factors that promote and impede the participation of parents in parent groups managed by the CHS during their child's first year. Twelve parents with children aged 10–12 months were interviewed during 2013. The interview text was analysed using qualitative manifest content analysis. The analysis resulted in eight categories. Those describing promoting factors were: feeling personally invited; having social hopes; being influenced by those around you; experiencing social fellowship; and being satisfied with the group leader. Categories describing impeding factors were: the parent group is not perceived to be addressed to both parents; the parents do not prioritise the group sessions offered; and expectations are not met. The study found that it is important for parents to feel personally invited and that the group leader's actions may be significant both for promoting and impeding participation in parent groups. The CHS nurse needs to be aware of parents' and children's individual needs and work actively to make all group participants feel included.
The visual style of Susanne Bier’s films
Authors: Højbjerg Lennard
Published: March 2018

This article analyses four of Susanne Bier’s films with regard to audio-visual style and the role of style in relation to the presented story. Bier’s visual style in the selected films – Open Hearts (2002), Brothers (2004), After the Wedding (2006) and In a Better World (2010) – is a combination of a generally applied style that I call Dogme light and one consisting of various small montages and extreme close-ups. The Dogme light style can be traced back to the tradition of realism, and Bier has used it consistently throughout her directing career, whereas her use of small montages has varied greatly from 2002 to 2010. By combining these two stylistic tendencies, Bier has become highly regarded internationally as an art-house director, while also reaching a broader audience in Scandinavia.
Triiodothyronine levels and mortality in children with sepsis and septic shock
Authors: Destariani Cynthea Prima , Lubis Munar , Deliana Melda , Yanni Gema Nazri
Published: March 2018

Background Sepsis is the most common cause of death in infants and children. It can cause hormonal imbalances, such as euthyroid sick syndrome (ESS), which may increase the risk of death.Objective To evaluate a possible correlation between the level of triiodothyronine (T3) and mortality in children with sepsis and septic shock.Methods An observational cohort study was conducted on 80 children with sepsis and septic shock from October 2015 until January 2016 in Haji Adam Malik General Hospital, Medan. Subjects underwent PELOD score and T3 examination on the first day admitted in Haji Adam Malik General Hospital. Chi-square test was used to analyze for a correlation between the T3 values and mortality. Results Of the 80 consecutive subjects, 39 (48.75%) had low T3 level on the first day. Of these 39 children, 36 (92.3%) died. Subjects with low T3 level had a 6.31 times higher risk of mortality(PR 6.31;  95%CI 2.99 to 13.28; P<0.001). Of the 31 subjects with high PELOD score, 23 (74.2%) had decreased T3 (PR=2.27; 95%CI 1.45 to 3.57; P<0.001).Conclusion Low T3 level has significant relationship with mortality in children with sepsis and septic shock.
Sleep disorders in children with attention-deficit/hyperactivity disorder
Authors: Permatawati Medina , Triono Agung , Sitaresmi Mei Neni
Published: March 2018

Background Attention-deficit/hyperactivity disorder (ADHD) is a neurobehavioral abnormality that commonly occurs among children. Sleep disorders are comorbid with ADHD. Sleep disorders in Indonesian children with ADHD have not been widely studied.Objective To understand the proportion and factors that influence sleep disorders in children with ADHD. Methods This cross-sectional study involved 54 children aged 3-14 years who had been diagnosed with ADHD by a pediatric growth and development consultant using DSM-5 criteria. The subjects were consecutively selected from March to August 2017 at the Child Development Polyclinic, Dr. Sardjito Hospital, Yogyakarta. Sleep data were collected using the Sleep Disturbances Scale for Children (SDSC) and the Children’s Sleep Hygiene Scale (CSHS).Results Of the 54 children with ADHD (46 males and 8 females), 35 (64.8%) experienced sleep disorders. The majority (26 subjects, 48.1%) had the disorder of initiating and maintaining sleep. Children with the combined (inattention and hyperactive-impulsive) type of ADHD experienced significantly greater sleep disturbance compared to the inattention type or hyperactive-impulsive type (OR=3.750; 95% CI 1.133 to 12.41; P=0.027). Poor sleep hygiene was also significantly associated with more severe sleep disorders (r=-0.383, P=0.004).Conclusion The proportion of sleep disorder in children with ADHD is relatively high, with the majority having a disorder of initiating and maintaining sleep. Children with combined type ADHD experience a higher amount of sleep disorder than those with either the inattention or hyperactive-impulsive types of ADHD. Children with poor sleep hygiene have significantly more severe sleep disorders.
Early detection of cerebral palsy in high-risk infants: diagnostic value of primitive and developmental reflexes as well as ultrasound
Authors: Handryastuti Setyo , Fadiana Ghaisani , Ismael Sofyan , Sastroasmoro Sudigdo , Aminulah Asril , Idris Ferial Hadipoetro , Saptogino Adji , Hapsara Sunartini
Published: March 2018

Background The incidence of cerebral palsy (CP) has increased due to better survival of high-risk babies. A simple assessment method is needed for the early detection of CP, which can be performed by general practitioners and pediatricians in daily practice.Objectives To assess motor delay, primitive and developmental reflexes, and cerebral ultrasound abnormalities as simple methods for early detection of CP in high-risk infants. We also aimed to evaluate the ease and consistency of the methods for use in daily practice, as well as determine risk factors associated with CP.Methods A prospective cohort study was done on 150 high-risk babies starting from the age of 4 months up to 12 months. We obtained subjects’ histories of motor ability and assessed primitive reflexes and postural reactions at the ages of 4, 6, 9 and 10 months. The diagnosis of CP was established at 6 and 12 months of age. We also determined Kappa test for inter-rater reliability between pediatric residents and pediatric neurologist.Results In 88.7% of subjects, CP was detected in the first 6 months. At 4 months, positive palmar reflex, head lag, and fisting were predictive of CP at 6 months of age. Motor delay, positive palmar grasp reflex, head lag, fisting, and absent protective extension reflex at 6 months were predictive of CP at 12 months. At 9 to 10 months, motor delays, absent protective extension reflex, and negative parachute reaction were predictive of CP at 12 months. Cerebral ultrasound abnormalities were predictive of CP at 6 and 12 months of age. Kappa test result was 0.9, indicating the ease and consistency of these methods for daily medical practice.Conclusion Cerebral palsy can be detected as early as the first 6 months of life. Assessment for motor delays, physical examination for asssessing primitive and developmental reflexes, and cerebral ultrasound can be used for this purpose.
Redução da jornada de trabaho do responsável legal por pessoa portadora de deficiencia dependente de terceiro sem efeito salarial
Authors: Serau Junior Marco Aurélio , Barbosa Ágatha Priscilla Dantas Nogueira , Rodrigues Maria Lúcia Soares
Published: March 2018

O presente estudo objetiva analisar a situação dos trabalhadores que necessitam, além de cumprir a jornada semanal de trabalho, cuidar de Pessoas com Deficiência (PcD) que são dependentes, levando esses trabalhadores a uma jornada dupla e exaustiva e que podem ter sérios conseqüências para empregador e para a sociedade. Hoje, para os trabalhadores celetistas, somente através do judiciário é possível conseguir a redução da jornada de trabalho semanal, sem redução de salários, para acompanhamento pelo empregado de pessoa sob sua dependência que necessita de auxilio de terceiros, mas mesmo judicialmente ainda são raras as decisões favoráveis. Diante desse quadro foi proposto o projeto de Lei nº 4.648, de 2016, em andamento na Câmara dos Deputados para acrescentar à Consolidação das Leis do Trabalho (CLT) o artigo 58-B, que disciplina a redução da jornada de trabalho do responsável legal por pessoa com deficiência dependente de terceiros. Após a propositura do projeto houve a determinação de apensamento ao PL 6828/201, atualmente o projeto tem andamento prioritário e está aguardando a apreciação do plenário.
Processos de participação e representação no movimento estudantil brasileiro (2002-2012)
Authors: Rodrigues Priscila Alves , Gugliano Alfredo Alejandro
Published: March 2018

Nesse trabalho, apresenta-se uma reflexão teórica sobre o movimento estudantil brasileiro com base nos trabalhos acadêmicos produzidos sobre o tema na última década (2002 a 2012) e, na análise de 14 estatutos de Diretórios Centrais de Estudantes (DCE's), contemplando as cinco regiões geográficas do país. Considerando as evidências empíricas do distanciamento observado entre o movimento estudantil e os estudantes nos dias de hoje, o presente trabalho tem seu foco na ampliação do conhecimento sobre a realidade política específica do movimento estudantil, tendo como pano de fundo o campo da Ciência Política Contemporânea. O objetivo deste estudo é analisar os processos de participação e representação presentes no movimento estudantil brasileiro. Para isso, foi realizado um estudo prioritariamente qualitativo, onde os dados foram coletados a partir da revisão da literatura e pesquisa documental. Como resultado da análise dos dados, pode-se verificar que diferentes perspectivas sobre movimento estudantil são abordadas, porém um número reduzido de artigos trabalham com o tema da participação política. Além disso, a análise dos estatutos das entidades selecionadas, permitiu uma avaliação sobre os espaços de representação presentes nos DCE's, além de apontar dificuldade de inserção de uma participação estudantil de fato no sistema de organização do movimento estudantil.
A ira dos anjos: uma análise psicológica e jurídica da alienação parental
Authors: Figueiredo Cláudia Roberta Leite Vieira
Published: March 2018

A síndrome de alienação parental (SAP) consiste num termo cunhado pelo psiquiatra norte-americano Richard Gardner, que a descreveu como um distúrbio infantil que acometia crianças e adolescentes envolvidos em situações de disputa de guarda judicial entre os pais. A SAP insere-se no contexto do Poder Judiciário em muitos casos de separação ou divórcio, quando marcas nocivas são deixadas em um dos cônjuges, o qual alimenta sentimentos de rancor, levando-o a criar falsas situações a partir de pensamentos irracionais, manipulando os filhos para que também desenvolvam sentimentos negativos em relação ao outro genitor, com objetivo de afastá-los totalmente de sua convivência com este. As discussões jurídicas em torno da SAP envolvem diversas ciências, especialmente a psicologia e a psiquiatria. No Brasil desde agosto de 2010, a Lei 12.318/2010 conceitua e reconhece a alienação parental (AP) e a SAP, alocando-as definitivamente no direito brasileiro. A Lei prevê sanções ao genitor que causar impedimentos à convivência do(s) filho(s) com o outro responsável. O presente trabalho tem como objetivo descortinar a SAP sob uma ótica multidisciplinar, abordando seus mais relevantes aspectos psicológicos e suas repercussões no âmbito jurídico.
Legenda Lok Laga (Studi Lirik Lagu Musik Panting Kalsel)
Authors: Maknun Moch Lukluil
Published: March 2018

This paper is the result of a transcription text analysis of a song titled "lok laga" hosted by panting music group in South Kalimantan. Using the qualitative approach and the semiotic method of Riffatere poems, it is found that this work is part of the oral tradition that is packed in the song. The purpose or function derived from this song are some things, among them are the description of the ideal traditional wedding of South Kalimantan in the past, the myth of the dragon which is a form of local wisdom and cultural fusion in Borneo, and the marker of a tourist site as a promotional event. Another interesting thing found in the lyrics is the songwriter's message to direct the listener to change the perception of myth into something less sacred.[Tulisan ini merupakan hasil analisis teks transkripsi sebuah lagu berjudul “lok laga” yang dibawakan oleh grup musik panting di Kalimantan Selatan. Dengan menggunakan pendekatan kualitatif dan metode semiotika puisi Riffatere didapatkan hasil bahwa karya ini merupakan bagian dari tradisi lisan yang dikemas dalam lagu. Tujuan atau fungsi yang didapatkan dari lagu ini ada beberapa hal, di antaranya adalah deskripsi pernikahan adat Kalimantan Selatan yang ideal pada masa lampau, mitos tentang naga yang merupakan bentuk kearifan lokal dan perpaduan budaya di Kalimantan, dan penanda situs wisata sebagai ajang promosi. Hal menarik lainnya yang ditemukan dalam lirik ini terdapat pesan pengarang lagu untuk mengarahkan pendengar mengubah persepsi mitos menjadi hal yang tidak terlalu sakral.]
Effects of fixture rotation on coating uniformity for high-performance optical filter fabrication
Authors: Rubin Binyamin , George Jason , Singhal Riju
Published: March 2018

Coating uniformity is critical in fabricating high-performance optical filters by various vacuum deposition methods. Simple and planetary rotation systems with shadow masks are used to achieve the required uniformity [J. B. Oliver and D. Talbot, Appl. Optics 45, 13, 3097 (2006); O. Lyngnes, K. Kraus, A. Ode and T. Erguder, in ‘Method for Designing Coating Thickness Uniformity Shadow Masks for Deposition Systems with a Planetary Fixture’, 2014 Technical Conference Proceedings, Optical Coatings, August 13, 2014, DOI: http://dx.doi.org/10.14332/svc14.proc.1817.]. In this work, we discuss the effect of rotation pattern and speed on thickness uniformity in an ion beam sputter deposition system. Numerical modeling is used to determine statistical distribution of random thickness errors in coating layers. The relationship between thickness tolerance and production yield are simulated theoretically and demonstrated experimentally. Production yields for different optical filters produced in an ion beam deposition system with planetary rotation are presented. Single-wavelength and broadband optical monitoring systems were used for endpoint monitoring during filter deposition. Limitations of thickness tolerances that can be achieved in systems with planetary rotation are shown. Paths for improving production yield in an ion beam deposition system are described.
On the formula of Cohen–Vogt relatively pointed topological semi-simplicial sets
Authors: Mdzinarishvili Leonard
Published: March 2018

In the papers [1] and [6], for an inverse sequence of pointed topological spaces and fibrations preserving the base points

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=

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1

←

p
1

E
2

←

p
2

⋯

←

p
m

E

m
+
1

,

E=E_{1}\xleftarrow{p_{1}}E_{2}\xleftarrow{p_{2}}\cdots\xleftarrow{p_{m}}E_{m+1},

there exists an exact sequence

*
→

lim
←

(
1
)

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,
Ω

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,

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)

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.

*\rightarrow{\varprojlim}^{(1)}[X,\Omega E_{m}]\rightarrow[X,\varprojlim E]%
\rightarrow{\varprojlim}^{(1)}[X,E_{m}]\rightarrow*.

In the present paper, for an inverse sequence of pointed topological semi-simplicial sets and fibrations preserving base points

E
¯

=

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,

\underline{E}=\underline{E}{}_{1}\xleftarrow{p_{1}}\underline{E}{}_{2}%
\xleftarrow{p_{2}}\cdots\xleftarrow{p_{m}}\underline{E}{}_{m+1}\xleftarrow{%
\hphantom{p_{1}}}\cdots,

an analogous formula is proved.
CD45RO regulates the HIV-1 gp120-mediated apoptosis of T cells by activating Lck
Authors: Li Kelei , Cong Zhe , Peng Zhuoying , Chen Ting , Xue Jing , Wei Qiang
Published: March 2018

CD45 has been reported to regulate the HIV-1 gp120-induced apoptosis of Jurkat cells. Here, we demonstrate that the extracellular domain of CD45 plays an important role in this function. We observed that CD45RO-transfected cells, but not cells transfected with other CD45 isoforms, underwent significant apoptosis induced by gp120. However, a CD45RA-transfected cell line treated with anO-glycan inhibitor was able to undergo apoptosis. The role of the extracellular domain of CD45 was further confirmed using CD45 isoform-transfected cell lines by analyzing the phosphorylation of Lck, which is a direct substrate of CD45 tyrosine phosphatase, and by using an Lck inhibitor. These results suggest that CD45RO modulates HIV-1 gp120-induced apoptosis by regulating the activity of Lck.
Two-Dimensional Deformation in a Thermoelastic Solid with Microtemperatures Subjected to an Internal Heat Source
Authors: Ailawalia P. , Budhiraja S. , Singh J.
Published: March 2018

The purpose of this paper is to study the two dimensional deformation in a generalized thermoelastic medium with microtemperatures having an internal heat source subjected to a mechanical force. The force is acting along the interface of generalized thermoelastic half space and generalized thermoelastic half space with microtemperatures having an internal heat source. The normal mode analysis has been applied to obtain the exact expressions for the considered variables. The effect of internal heat source and microtemperatures on the above components has been depicted graphically.
Experimental and Numerical Analysis of Fracture in 41Cr4 Steel – Issues of the Stationary Cracks
Authors: Graba M.
Published: March 2018

This paper analyzes the process of fracture in 41Cr4 steel on the basis of experimental and numerical data obtained for non-propagating cracks. The author’s previous and latest experimental results were used to determine the apparent crack initiation moment and fracture toughness for the material under plane strain conditions. Numerical simulations were carried out to assess changes in the J-integral, the crack tip opening displacement, the size of the plastic region and the distribution of stresses around the crack tip. A complex numerical analysis based on the true stress-strain curve was performed to determine the behavior of 41Cr4 steel under increasing external loads.
Stability Assessment as a Criterion of Stabilization of the Movement Trajectory of Mobile Crane Working Elements
Authors: Kacalak W. , Budniak Z. , Majewski M.
Published: March 2018

The article presents a stability assessment method of the mobile crane handling system based on the safety indicator values that were accepted as the trajectory optimization criterion. With the use of the mathematical model built and the model built in the integrated CAD/CAE environment, analyses were conducted of the displacements of the mass centre of the crane system, reactions of the outrigger system, stabilizing and overturning torques that act on the crane as well as the safety indicator values for the given movement trajectories of the crane working elements.
Increase in an Intracellular β-Galactosidase Biosynthesis Using L. reuteri NRRL B-14171, Inducers and Alternative Low-Cost Nitrogen Sources under Submerged Cultivation
Authors: Gomes Tatiane A. , Santos Luiza B. , Nogueira Alessandro , Spier Michele R.
Published: March 2018

The aim of this study was to select among lactic acid bacteria (LAB) and yeast a potential β-galactosidase producer, based on bioprocess parameters. From the selected microorganism,  different organic cheaper nitrogen sources (single and combined) with low cost for β-galactosidase production were evaluated. Lactobacillus reuteri B-14171 showed the highest enzymatic activity (1,286 U L−1), high productivity (28.78 U L h−1) and yield factor (82.32 U g−1), evidencing its potential for β-galactosidase production. All organic nitrogen sources tested were viable for the enzymatic production using L. reuteri B-14171. The MMRS casein (3.0 g L−1) + inactive beer yeast (3.0 g L−1) as nitrogen source increased the enzymatic activity (1269 U L−1) with 1.83 times lower production costs of culture medium when compared to MMRS-yeast extract B. The MMRS casein + inactive beer yeast has proved to be an innovative and cheaper nitrogen source for β-galactosidase production by L. reuteri B-14171.
Global Mittag–Leffler Synchronization for Impulsive Fractional-Order Neural Networks with Delays
Authors: Rifhat Ramziya , Muhammadhaji Ahmadjan , Teng Zhidong
Published: March 2018

In this paper, we investigate the synchronization problem of impulsive fractional-order neural networks with both time-varying and distributed delays. By using the fractional Lyapunov method and Mittag–Leffler function, some sufficient conditions are derived to realize the global Mittag–Leffler synchronization of impulsive fractional-order neural networks and one illustrative example is given to demonstrate the effectiveness of the obtained results.
Understanding the direct involvement of parents in policy development and school activities in a primary school
Authors: Tobin Bernie
Published: March 2018

It is acknowledged that parental engagement with children’s learning and education is of vital importance. But, there is a tendency to confuse engagement with learning with engagement with the school. While all types of parents’ involvement can have a positive effect, it is actually what parents do with their child at home that has the greatest impact. However, unless parental involvement in learning is embedded in whole-school processes it is unlikely to as effective as possible. This paper documents an action research study that explores the inclusion of parents and home values in the construction of the teaching and learning environment. This was a small step towards positive parent-teacher collaboration, which allowed an exchange of knowledge, values and cultural background experiences. In acknowledging the ways in which the parents already engaged with their children’s learning, it began to enhance self-efficacy in their ability to directly affect this learning. This work has also provoked reflexive engagement of my influence and understanding of involving parents of children with additional and diverse learning needs. But, it also details the transformative journey that influenced my thinking about how we as a school could begin to develop whole-school processes to directly involve parents in policy development and school activities.
Mapping tense form and meaning for L2 learning – From theory to practice
Authors: Svalberg Agneta Marie-Louise
Published: March 2018

English tense presents second/foreign language learners with considerable cognitive challenges and, it will be argued, grammars and textbooks are generally inadequate sources of knowledge of the tense system as system. A modified version of Reichenbach's (1947.Elements of Symbolic Logic. New York: Macmillan) tense model is then presented. The original model has been criticized for its inability to deal with temporal relationships in natural text (e. g. Declerck, R. 1986. From Reichenbach (1947) to Comrie (1985) and beyond. Towards a theory of tense.Lingua70. 305–364; Declerck, R. 2015.Tense in English. Its structure and use in discourse. London: Routledge; Carroll, M., C. Von Stutterheim & W. Klein. 2003. Two ways of construing complex temporal structures. In F. Lenz (ed.),Deictic Conceptualisation of Time, Space and Person, 97–134. Amsterdam: Benjamins). It is argued here instead that speakers employ the limited choices the system provides creatively, to express a wide range of temporal and interpersonal relations in the real world. The tense - aspect and tense - modality interfaces are briefly discussed. A pedagogical Language Awareness approach (Svalberg, A. M-L. 2007. Language Awareness and Language Learning.Language Teaching40(4). 287–308) is then illustrated, with the theoretical model as mediating artefact providing visual and metalinguistic scaffolding, allowing learners to investigate tense use in context while drawing on both intuitive understanding and conscious knowledge.
Directionality and complexity of L1 transfer in L2 acquisition: Evidence from L2 Chinese discourse
Authors: Yuan Boping , Lin Yvonne
Published: March 2018

First language (L1) transfer is a common phenomenon in second language (L2) acquisition. However, it will be argued in this article that although there are indeed pervasive influences of learners’ L1 in L2 acquisition, L1 transfer is not everywhere and it can be directional. We compare data from Chang’s (2001b. Discourse effects on the second language acquisition of English and Chinese dative structures. Honolulu: University of Hawai’i at Manoa PhD dissertation, 2004. Discourse effects on EFL learners’ production of dative constructions. Journal of Kaohsiung University of Applied Sciences 33. 145–169.) studies of Chinese-speaking learners of English with data of our study of English-speaking learners of Chinese to examine whether their L2 English discourse and L2 Chinese discourse are equally influenced by their L1 discourse rules. We focus on learners’ answers to wh-questions with a double object construction or a prepositional object construction. The results demonstrate that L1 transfer takes place in Chinese-speaking learners’ L2 English discourse but not in English-speaking learners’ L2 Chinese discourse. This directionality of L1 transfer is accounted for on the basis of computational complexity of linguistic structures involved and on an economical consideration.
Recent developments in cell-based ENS regeneration – a short review
Authors: Obermayr Florian , Seitz Guido
Published: March 2018

Therapeutic options to treat neurogenic motility disorders of the gastrointestinal tract are usually limited to symptomatic treatment. The capacity of the enteric nervous system (ENS) to regenerate and the fact that progenitor cells of the enteric nervous system reside in the postnatal and adult gut led to the idea to develop cell-based strategies to treat ENS related disorders. This short review focuses on recent developments in cell-based ENS regeneration, discussing advantages and disadvantages of various cell sources, functional impact of transplanted cells and highlights the challenges of translation of small animal studies to human application.
Will Total Knee Replacement Ever Provide Normal Knee Function?
Authors: Gergely István , Pop Tudor Sorin , Bățagă Tiberiu , Feier Andrei-Marian , Zuh Sándor-György , Russu Octav
Published: March 2018

Knee osteoarthritis or gonarthrosis is considered the most common joint disease, affecting more than 70% of subjects aged over 65 years. Its occurrence is increasing with age and is more problematic with the current rise in the incidence of obesity. In severe and advanced cases, total knee arthroplasty is recommended as a gold standard therapy for pain relief, restoration of normal knee function, and quality of life improvement. There are numerous controversies whether total knee arthroplasty is able to reach and provide end-point outcomes and restore previous function of the knee joint. Studies suggest that the surgeons’ experience, type of prosthesis used, associated pathology, underlying pathologies, risk factors, continuous passive movement, and patient expectations about the surgery may influence the outcomes to a great extent. “Normal knee function” is a statement that is hardly defined in the current literature, as authors usually refer to subjective results when analyzing outcomes. Objective results may be more straightforward, but they do not always symbolize the actual state that the patient is reporting or the actual quality of life. Our objective was to analyze and present summaries of the current literature regarding normal knee function restoration after total knee replacement surgery. Our literature review results confirm the hypothesis that subjective and objective results are difficult to interpret and unravel. Complex future trials may bring supplementary and clearer conclusions regarding knee function and kinematics, clinical improvement, patient satisfaction, and quality of life.
Imaging-derived Biomarkers Associated with Atrial FIBROsis, Structural Remodeling and the Risk of Cardioembolic Events in Patients with Atrial Fibrillation – the FIBROS Study
Authors: Oltean-Péter Balázs , Korodi Szilamér , Benedek István , Lázár Erzsébet , Kéri Johanna , Pakucs Annamária , Kovács István , Bordi Lehel , Mitre Adriana , Benedek Imre , Benedek Theodora , Benedek István
Published: March 2018

Recent studies demonstrated that despite restoration of the sinus rhythm, patients with a positive history of atrial fibrillation (AF) are still at risk of thromboembolic events. The primary objective of this study is to identify new imaging-derived biomarkers provided by modern imaging technologies, such as cardiac computed tomography angiography, delayed enhancement magnetic resonance imaging, or speckle tracking echocardiography, as well as hematological biomarkers, associated with the risk of intracavitary thrombosis in patients with AF, in order to identify the imaging-derived characteristics associated with an increased risk of cardioembolic events. Imaging data collected will be post-processed using advanced techniques of computational modeling, in order to fully characterize the degree of structural remodeling and the amount of atrial fibrosis. The primary endpoint of the study is represented by the rate of thromboembolic events. The rate of cardiovascular death, the rate of major adverse cardiovascular events, and the rate of AF recurrence will also be determined in relation to the degree of structural remodeling and atrial fibrosis.
Foreign Relations of Post-Independence Montenegro: A Change of Direction
Authors: Vukicevic Boris
Published: March 2018

Montenegro, the smallest country in the Balkans, had led a long struggle for independence against various empires. Because of Montenegrin Orthodox Christian and Slavic heritage, Russia was historically its main patron. However, after regaining independence in 2006, Montenegro set amongst its top priorities the membership in the European Union and NATO, whilst trying to pursue good relations with other actors in the region. This paper deals with the adaptability of a small country to changes of regional and global context whilst comparing its relations with its former and contemporary allies. It also deals with a set of its foreign and security policy priorities and how they are fulfilled.
Generalized state maps and states on pseudo equality algebras
Authors: Cheng Xiao Yun , Xin Xiao Long , He Peng Fei
Published: March 2018

In this paper, we attempt to cope with states in a universal algebraic setting, that is, introduce a notion of generalized state map from a pseudo equality algebra X to an arbitrary pseudo equality algebra Y. We give two types of special generalized state maps, namely, generalized states and generalized internal states. Also, we study two types of states, namely, Bosbach states and Riečan states. Finally, we discuss the relations among generalized state maps, states and internal states (or state operators) on pseudo equality algebras. We verify the results that generalized internal states are the generalization of internal states, and generalized states are the generalization of state-morphisms on pseudo equality algebras. Furthermore, we obtain that generalized states are the generalization of Bosbach states and Riečan states on linearly ordered and involutive pseudo equality algebras, respectively. Hence we can come to the conclusion that, in a sense, generalized state maps can be viewed as a possible united framework of the states and the internal states, the state-morphisms and the internal state-morphisms on pseudo equality algebras.
Monotone subsequence via ultrapower
Authors: Błaszczyk Piotr , Kanovei Vladimir , Katz Mikhail G. , Nowik Tahl
Published: March 2018

An ultraproduct can be a helpful organizing principle in presenting solutions of problems at many levels, as argued by Terence Tao. We apply it here to the solution of a calculus problem: every infinite sequence has a monotone infinite subsequence, and give other applications.
Evaluation of a neurokinin-1 antagonist in preventing multiple-day cisplatin-induced nausea and vomiting
Authors: Li Quanfu , Wang Wenjuan , Chen Gang , Deng Shuqin , Jiang Caihong , Chen Feng , Zhao Jun , Li Hui , Bai Xiaojun , Hu Yuliang , Da Lenggaowa , Wu Yungaowa , Jin Gaowa
Published: March 2018

Objective

To perform a prospective non-randomized comparison of the effectiveness and safety of combined neurokinin-1 antagonist aprepitant treatment with the standard multiple-day cisplatin regimen for the prevention of cisplatin-induced nausea and vomiting (CINV).

Methods

Patients being administered 3-day cisplatin-based chemotherapy (25 mg/m2/d) who had never received aprepitant were given either the standard regimen (tropisetron and dexamethasone) or the aprepitant regimen (aprepitant plus tropisetron and dexamethasone). The primary endpoint was the complete response (CR) in the overall phase (OP, 0–120 h) between the combined aprepitant triple regimen group and the standard group. Secondary endpoints were the CR in the acute phase (AP, 0–24 h) and delay phase (DP, 25–120 h) between the two groups. The first time of vomiting was also compared by Kaplan–Meier curves. The impact of CINV on the quality of life was assessed by the Functional Living Index-Emesis (FLIE). Aprepitant-related adverse effects (AEs) were also recorded.

Results

A CR was achieved by 80.0% in the aprepitant group compared with 56.0% in the standard group during the OP (P =0.018)as well as during the DP. However, during the AP, the aprepitant and standard therapy groups achieved identical CR rates (98.0%, P =1.000). A longer time to first emesis was documented for the aprepitant group than for the standard group. No effect of CINV on quality of life as assessed by FLIE was reported by 44.7% of aprepitant therapy patients and 24.0% of standard therapy patients (P=0.035). The main aprepitant-related AEs were fatigue and constipation, but there was no significant difference between groups.

Conclusion

Combined aprepitant therapy is recommended for the prevention of multiple-day CINV because of its improved CINV control rate and safety.
Value of continuous video EEG and EEG responses to thermesthesia stimulation in prognosis evaluation of comatose patients after cardiopulmonary resuscitation
Authors: Jianmin Qiu , Xueliang You , Liqin Liu , Yongsheng Wu , Licang He , Yuanxin Huang
Published: March 2018

Objective

To investigate the clinical value of video-electroencephalography (VEEG) and thermal stimulus on evaluating the prognosis of comatose patients after cardiopulmonary resuscitation.

Methods

Twenty eight comatose patients with cardiopulmonary resuscitation were included in the department of ICU of the First Teaching Hospital of Fujian Medical University from February 2013 to March 2016. Of the included 28 patients, 20 cases died (death group) and 8 cases survived (survival group) after cardiopulmonary resuscitation. The VEEG, Glasgow Coma Scale (GCS) and APACHE II score were recorded and compared between the death and survival group. The prediction value of death for VEEG, GCS and APACHE II were evaluated through sensitivity, specificity and area under the receiver operating characteristic (ROC) curve (AUC).

Results

GCS and APACHEH II score were statistical different between the death and survival group (P<0.05). With the increase of VEEG grading, the mortality rate of patients increased significantly (P<0.05). Predicting value of mortality for GCS, VEEG and APACHEH II were 57.69%, 61.54% and 71.43% respectively without statistical difference (P>0.05). The death prediction sensitivity and specificity for GCS were 67.0% and 85.0%, for APACHEH II were 95.1% and 85.0%, for VEEG were 100.0% and 85.2%. VEEG has the highest sensitivity, Specificity, coincidence rate and Kappa vale compared to GCS, and APACHEH II.

Conclusion

Video-electroencephalography is a useful tool for predicting the death risk for patients who received cardiopulmonary resuscitation.
Chemically vapor deposited diamond films as dosimetric material for potential clinical applications
Authors: Kabacińska Renata , Winiecki Janusz , Przegiętka Krzysztof , Szybowicz Mirosław , Fabisiak Kazimierz , Paprocki Kazimierz
Published: March 2018

Thermally stimulated luminescence (TL), cathodoluminescence (CL) and Raman spectroscopy of CVD diamond films grown on silicon substrates have been studied in order to obtain information on defects created during the growth, which induce the levels within the gap. TL between 300 K and 700 K, and CL from 200 nm to 1200 nm have been teasured. The glow curves show a peak located around 610 K with different intensities, depending on the sample thickness, associated with a trap of energy, equal to 0.83 eV and with attempt-to-escape-time of the order of 108 s-1. Broad CL bands observed at 428±1 nm (2.90 ±0.01 eV) and 500±1 nm (2.47±0.004 eV) are attributed to closely spaced and widely separated donor-acceptor (D-A) pairs, respectively. The TL and CL results were correlated with diamond quality estimated from Raman spectroscopy measurements.
Management als Qualifizierungsziel für Gesundheitsberufe
Authors: Hensen Peter
Published: March 2018

Der Managementbegriff im Gesundheits- und Sozialwesen umgreift mehr als Betriebswirtschaft und Ressourcenallokation in Versorgungseinrichtungen. Konstruktivistisch steht er für eine „reflexive Gestaltungspraxis“ zur Erschließung unterscheidbarer Praxisfelder, in denen die Gesundheitsberufe und die Berufsangehörigen eine aktive und verantwortliche Rolle einnehmen. Dies bedeutet, die primärfachlichen Kompetenzen um zusätzliche konzeptionelle, technische/funktionale und soziale Managementkompetenzen zu erweitern.
Ausbildung und Einsatz für die Katastrophen- und Notfallversorgung am Beispiel wetterbedingter Ereignisse
Authors: Ulrichs Timo , Goersch Henning
Published: March 2018

Extreme Wetterereignisse der letzten Jahre zeigen eindrücklich die Notwendigkeit einer guten Aufstellung von Katastrophen- und Notfallversorgung in Deutschland. Eine gute Abstimmung der Institutionen und Akteure untereinander sowie die Sicherstellung von qualifiziertem Nachwuchs bilden zusammen die Grundlage für eine adäquate Vorbereitung.
Covalent immobilization of an alkaline protease from Bacillus licheniformis
Authors: Aslan Yakup , Ömerosmanoğlu Derya , Koç Eda Öndül
Published: March 2018

Objective

Since the soluble enzymes can not be used in repeated reactions and are not stable in operational conditions and not suitable for continuous processes, this study aimed the covalent immobilization of Bacillus licheniformis protease (BLP) onto Eupergit CM.

Methods

Optimum conditions for immobilization were determined by changing the conditions individually. The proteins and L-tyrosine were determined by UV/VIS spectrophotometer.

Results

The immobilization resulted in 100% immobilization and 107.7% activity yields. The optimum pH (7–8) and the optimum temperature (70°C) have not changed after immobilization. The Km values for free and immobilized enzyme were 26.53 and 37.59 g/L, while the Vmax values were 2.84 and 3.31 g L-Tyrosine/L·min, respectively. The immobilized enzyme has not lost its initial activity during the repeated 20 uses and 20 days of storage. The milk proteins were hydrolyzed in 2 h by using immobilized enzyme. The pH of the milk dropped from 6.89 to 6.53, the color was clearer but there was no change in the smell or the taste.

Conclusion

Consequently, it can be said that the immobilized BLP obtained can be used for industrial purposes.
Optimized production, purification and molecular characterization of fungal laccase through Alternaria alternata
Authors: Irfan Muhammad , Mehmood Sajid , Irshad Muhammad , Anwar Zahid
Published: March 2018

Objective

Industrial effluents and agriculture biomass are main environmental hazards which are facing by developing country like Pakistan. Along with various other industrial applications, laccases are also involved in the oxidation of various industrial hazardous compounds to detoxify them. This study was designed to produce and purify laccase from ascomyceteous fungi, i.e. Alternaria alternata through solid stat fermentation.

Materials and methods

Abundantly available Sarkanda grass “Saccharum spontaneum” was used as agro-waste substrate for laccase production from fungus A. alternata. Previously only white rot fungi are familiar for laccase production and almost no work has been done on laccase production by A. alternata. In this research work, different physical and chemical parameters were optimized for maximum laccase production through solid state fermentation (SSF).

Results

Enzyme was purified and its molecular weight was determined by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE). Maximum laccase activity (21.87±0.0115 unit/mL) was detected on 7th day of incubation having pH 5 of the medium at 35°C. None of the added metal ions increased laccase production. Galactose and “yeast extract” used as optimum carbon and nitrogen source for highest laccase production.

Conclusion

A monomeric protein (laccase) having approximately 51 kDa molecular weight obtained after SDS-PAGE.
Synthesis, characterization, anticancer and antimicrobial study of arene ruthenium(II) complexes with 1,2,4-triazole ligands containing an α-diimine moiety
Authors: Gichumbi Joel M. , Friedrich Holger B. , Omondi Bernard , Lazarus Geraldine G. , Singh Moganavelli , Chenia Hafizah Y.
Published: March 2018

The reaction of the ruthenium arene dimers [(η
6-arene)Ru(μ-Cl)Cl]2 (where arene=benzene or p-cymene) with the ligands 4-benzylidene-3,5-di(2′-pyridyl)-4-amino-1,2,4-triazole (L1
), 2-methoxybenzylidene-3,5-di(2′-pyridyl)-4-amino-1,2,4-triazole (L2
), 4-methylbenzylidene-3,5-di(2′-pyridyl)-4-amino-1,2,4-triazole (L3
) and indole-3-carbaldehyde-3,5-di(2′-pyridyl)-4-amino-1,2,4-triazole (L4
) in a 1:2 ratio gives the new complexes [(η
6-arene)RuCl(L)]+ [arene=C6H6 (with L=L1(1), L2(3), L4(7), with PF6
− as a counter ion, and L4 (6), with Cl− as a counter ion) or p-cymene with L=L1(2), L2(4), L3(5), L4(8) with PF6
− as a counter ion]. All complexes were fully characterized using 1H and 13C NMR, elemental analyses, UV/Vis and IR spectroscopy. The single crystal X-ray structures of ligand L2
and complex 1 have been determined. The structure of 1 has the Ru atom coordinated with the arene group and to the N,N′-bidentate ligand and to the Cl atom. The arene group occupies the apex, while the ligand and the Cl atom are at the base of a pseudo-octahedral three-legged piano stool. The cytotoxicity of these mononuclear complexes was established in the human epithelial colorectal adenocarcinoma cell line (Caco-2) and for selectivity in the non-cancerous human embryonic kidney cell line (HEK293), using 5-fluorouracil (5-FU) as the reference anticancer drug. Compounds 1 and 7 were relatively inactive toward the Caco-2 tumor cells (IC50>200), while complexes 2–5 showed moderate anti-proliferative properties (IC50>100–200). Compound 6, however, displayed better anti-proliferative properties with an IC50 value lower than that of the reference drug, 5-FU, and was therefore further investigated for its antimicrobial activity against six Gram-positive and four Gram-negative bacteria.
Priority Program of Unemployment Problem Solving in Pati Regency
Authors: Arivia Roseline Erni , D.W.P Sucihatiningsih
Published: March 2018

Pati is one regency that has the population with labor problems that is unemployment, and in 2013 Pati is a regency / city in Central Java with the fourth rank of unemployment rate. This research aims to make some program alternatives and to determine which alternative program that can be prioritized by the Government of Pati Regency in reducing the unemployment rate. The research uses the primary and secondary data. The analytical method used is Analysis Hierarchy Process (AHP) and it is processed using the expert choice version 9.0. The result of research indicates that the efforts to reduce the unemployment rate in Pati Regency can be prioritized on the criterion: (1) empowering the people, and followed by (2) the capital from the investors, and (3) the empowerment of economic business. And the priority scale from the entire program alternatives of unemployment problem solving is a program to improve the rural community empowerment. The advice that can be given from this research is that the Government of Pati Regency should continuously conduct the job training and coaching to improve the quality and skills of the labors and also should increase the job opportunities, and also should improve and perform the continuous improvement program of increasing the community empowerment so that the rural communities may have good quality to be able to compete with other labors.
Disparitas Pembangunan Wilayah Kabupaten/ Kota di Provinsi Jawa Tengah
Authors: Ika Wahyuntari Linda , Pujiati Amin
Published: March 2018

Penelitian ini bertujuan untuk mengidentifikasi klasifikasi daerah cepat maju dan cepat tumbuh, menganalisis pengaruh aglomerasi industri, dana perimbangan, IPM, dan klasifikasi daerah cepat maju dan cepat tumbuh terhadap disparitas pembangunan wilayah kabupaten/ kota di Provinsi Jawa Tengah. Penelitian ini menggunakan metode analisis deskriptif Tipologi Klassen dan analisis regresi data panel dengan metode Generalized Least Square (GLS). Hasil identifikasi kabupaten/ kota yang konsisten berada di klasifikasi daerah cepat maju dan cepat tumbuh dalam kurun waktu tahun 2009-2013, yaitu Kabupaten Cilacap, Kota Magelang, Kota Surakarta, dan Kota Semarang. Hasil dari penelitian ini menunjukkan bahwa aglomerasi industri berpengaruh positif dan signifikan, sedangkan dana perimbangan, IPM, dan klasifikasi daerah cepat dan cepat tumbuh berpengaruh negatif dan signifikan terhadap disparitas pembangunan wilayah kabupaten/ kota di Provinsi Jawa Tengah.

This study aims to identify the classification of the area fast forward and fast-growing, analyze the effect of industrial agglomeration, the balance funds, HDI, and area classification fast forward and fast-growing against the disparity of development districts/ cities in Central Java province. This research using descriptive analysis Typology Klassen and panel data regression analysis with the method of Generalized Least Square (GLS). The results of the identification of districts/ cities that are in the area classification consistently fast forward and fast-growing in the period 2009-2013, namely Kabupaten Cilacap, Kota Magelang, Kota Surakarta and Kota Semarang. The results of this study indicate that the industrial agglomeration effect on positive and significant, while the balance funds, HDI, and the classification of fast and fast-growing regions a significant negative effect on the development disparity districts/ cities in Central Java province.