bluuebunny/crossref_metadata_2025 huggingface dataset:
Penggunaan Path Analysis Dalam Analisis Pengaruh Efisiensi Operasional, Tingkat Kecukupan Modal Dan Likuiditas Terhadap Profitabilitas Bank Umum Syariah Di Indonesia Tahun 2011-2014
Authors: Prasetyoningrum Ari Kristin , Hasanah Siti Nur
Published: January 2018

This study was to determine the effect of Operating Costs (ROA), level of capital adequacy (CAR), and Liquidity (QR) to Profitability (ROA) at the Islamic Banks in 2011-2014. This study used quantitative research methods. Source of research data are secondary data from the quarterly financial statements of Islamic Banks in 2011 to 2014 were obtained from the website. This study using path analysis because there are two models of the equation (substructure) with IBM SPSS application program. Purposive sampling technique is used to determine number of sample. The sample was seventh quarterly financial statements Islamic Bank (BRI Syariah, Bank Syariah Mandiri, Bank Panin Syariah, BCA Syariah, Bank Mega Syariah, and Maybank Syariah) from 2011 to 2014, each bank was obtained 16 financial statements in order to obtain 112 data. The results of this study indicate that the Operating Costs (ROA), level of capital adequacy (CAR), and Liquidity (QR) had an influence on profitability (ROA). There are also indirect influence between the level of capital adequacy (CAR) to Profitability (ROA) through Liquidity (QR), the liquidity position (QR) as the weakening of the influence.
Impaired Cargo Clearance in the Retinal Pigment Epithelium (RPE) Underlies Irreversible Blinding Diseases
Authors: Keeling Eloise , Lotery Andrew J. , Tumbarello David A. , Ratnayaka J. Arjuna
Published: January 2018

Chronic degeneration of the Retinal Pigment Epithelium (RPE) is a precursor to pathological changes in the outer retina. The RPE monolayer, which lies beneath the neuroretina, daily internalises and digests large volumes of spent photoreceptor outer segments. Impaired cargo handling and processing in the endocytic/phagosome and autophagy pathways leads to the accumulation of lipofuscin and N-retinylidene-N-retinylethanolamine aggregates and chemically-modified compounds such as malondialdehyde and 4-hydroxynonenal within RPE. These contribute to increased proteolytic and oxidative stress, resulting in irreversible damage to post-mitotic RPE cells and development of blinding conditions such as Age-related Macular Degeneration, Stargardt disease and Choroideremia. Here, we review how impaired cargo handling in the RPE results in their dysfunction, discuss new findings from our laboratory and consider how newly discovered roles for lysosomes and the autophagy pathway could provide insights into retinopathies. Studies of these dynamic, molecular events have also been spurred on by recent advances in optics and imaging technology. Mechanisms underpinning lysosomal impairment in other degenerative conditions including storage disorders, a-synuclein pathologies and Alzheimer’s disease are also discussed. Collectively, these findings help transcend conventional understanding of these intracellular compartments as simple waste disposal bags to bring about a paradigm shift in the way lysosomes are perceived.
Anti-Proliferation, Pro-Apoptosis and Anti-Migration Effects of Ginkgolic Acid C13:0 Isolated from Ginkgo Biloba Exocarp in MCF-7 and 4T-1 Breast Cancer Cells
Authors: Zhou Da-Yu , Jiang Chun-Ying , Fu Cheng-Hao , Chang Ping , Wu Jia-Di , Zheng Ke-Xin , Zhao Xiao-Hui , Ma Shi-Liang
Published: January 2018

Ginkgolic acids (GA) have been reported to exhibit anticancer properties, however, the mechanisms remain unclear. This study aims to investigate the mechanisms of GA C13:0 that was isolated from Ginkgo biloba exocarp (GBE) for anti-proliferation, pro-apoptosis and anti-migration effects in human MCF-7 and mouse 4T-1 breast cancer cells. The cytotoxic effect, apoptosis induction and migration inhibition were measured using MTT, TUNEL and Wound healing assays. The expression of mRNA and protein were determined using qPCR and Western blot. Our results showed that no cytotoxicity was found at concentrations of C13:0 below 100µM. The effects of GA C13:0 was further demonstrated by up-regulation of the Bax/Bcl-2 apoptosis pathway and the expression of Apaf-1 protein in the mitochondria. In addition, GA C13:0 also suppressed cell migration and epithelial to mesenchymal transition (EMT) with the increase of E-cadherin expression accompanied by the decrease of Snail, MMP-2, MMP-9 and Vimentin expression. Moreover, GA C13:0 induced cytochrome P450 (CYP) 1B1 expression in aryl hydrocarbon receptor (AhR) pathway. Notably, the up-regulation of CYP1B1 also might play a pivotal regulatory role in mitochondrial and EMT pathways in MCF-7 and 4T-1 cells. Our results may have implications for the development of anticancer agents containing GA as functional additives.
Moving in the Circle: Indigenous Solidarity for Canadian Libraries
Authors: Blair Julie , Wong Desmond
Published: January 2018

Libraries face new challenges in an era of reconciliation with Indigenous peoples as First Nations, Métis and Inuit communities are reclaiming their voices and building a new framework for its relationship with other Canadians. In order for libraries to begin the process of responding to the Truth and Reconciliation Commission’s 94 Calls to Action, library staff should educate themselves on the role that the library has played in the marginalization of Indigenous peoples. As 2017 marked both the 150th anniversary of Confederation and the 140th anniversary of the Indian Act, it is an appropriate time to reflect on the relationship between Indigenous peoples and settlers, especially in the context of library. This paper aims to introduce some of the systems that define settler-Indigenous relationships and proposes solidarity and relationship building as a path towards reconciliation.

Les bibliothèques font face à de nouveaux défis dans une ère de réconciliation avec les peuples autochtones alors que les communautés des Premières nations, des Métis et des Inuits retrouvent leurs voix et établissent une nouvelle structure pour leurs relations avec les autres Canadiens. Pour que les bibliothèques puissent commencer à répondre aux 94 appels à l'action lancés par la Commission de vérité et réconciliation, le personnel des bibliothèques devrait se renseigner sur le rôle qu'elles ont joué dans la marginalisation des peuples autochtones. Comme l'année 2017 marquait à la fois le 150e anniversaire de la Confédération et le 140e anniversaire de la Loi sur les Indiens, le moment est venu de réfléchir aux relations entre les peuples autochtones et les colonisateurs, surtout dans le contexte des bibliothèques. Cet article vise à présenter certains des systèmes qui définissent les relations entre colonisateurs et autochtones, et propose que la solidarité et l'établissement de bonnes relations façonnent la voie vers la réconciliation.
Community-led Digital Exhibits Service at the Edmonton Public Library: Research and Consultation
Authors: Zvyagintseva Lydia
Published: January 2018

This paper presents the findings of the community consultation and research conducted as part of the Digital Exhibits Intern Librarian Project at the Edmonton Public Library in 2016. The research project aimed to understand the local context for a new technology service in Edmonton, including the capacity for content creation and partnership among community organizations aligned with the Library’s mission. The study consisted of a survey and a series of semi-structured interviews. Findings include identification of various audiences and topics for digital projects, prioritization of Library and community partner roles in digital project collaborations, and identification of major components of digital exhibits as areas of project management workflows.

Cet article présente les résultats d'une recherche et d'une consultation communautaire menées dans le cadre du Digital Exhibits Intern Librarian Project de la bibliothèque publique d'Edmonton en 2016. Ce projet de recherche visait à mieux comprendre le contexte local pour un nouveau service technologique à Edmonton qui comprend la capacité de créer du contenu et d'établir des partenariats avec des organismes communautaires alignés à la mission de la bibliothèque. Un sondage et une série d'entrevues semi-dirigées ont été utilisés lors de cette étude. Les résultats incluent l'identification de divers auditoires et sujets pour des projets numériques, la priorisation des rôles de la bibliothèques et des partenaires communautaires au sein des projets numériques collaboratifs, et l'identification de principales composantes des expositions numériques en tant que déroulement de projet.
Roundtable: Should library workers learn to code?
Authors: Tillman Ruth , Harnum Alan , Robichaud Danielle , Zingarelli-Sweet Anna-Sophia , Houston Brad
Published: January 2018

For this issue, we asked readers responding to our recent pieces about technology, programming, and self-directed learning to tell us: should we expect LIS professionals to learn how to code? Answers came long, short, and even in haiku form. Enjoy!
Technology Update: Big Data for Advanced Well Engineering Holds Strong Potential To Optimize Drilling Costs
Authors: Rossi Nicola , Michelez Jean , Concina Fabio
Published: January 2018

Technology Update

Considering the significant weight of drilling costs in upstream ventures, saving even a few hours of drilling could lead to substantial cost savings on the overall capital expenditures (Capex). Thanks to the big data revolution, cost optimization still has strong potential in drilling operations.

Traditionally, drilling performance has been addressed through the analysis of drilling reports written once a day by the operator’s staff. However, high-frequency data are already collected continuously by surface and downhole sensors to address operational safety and continuity. These data contain a huge amount of valuable information that can be used for drilling operations performance analysis (Fig. 1).

High-frequency data analysis allows a new level of performance monitoring through the identification of potential invisible lost time and the anticipation of well problems that could be minimized to reduce drilling costs.

Data Valorization, Combination

More than 60 sensors record high-frequency data during drilling, creating sets of millions of data for a single well. These data can be reprocessed through a set of algorithms to identify each single activity with the highest possible level of accuracy and granularity. As an example, reaming is based on the following seven surface logging parameters: bit depth, well depth, rate of penetration (ROP), weight on bit (WOB), torque, mud flow-in, and standpipe pressure.

However not all activities can be automatically detected through surface log-data interpretation. It they cannot be, daily reporting becomes a relevant source of information. Thus, a set of preeminence rules is applied so that the most relevant data can be used and combined as needed at any time to build a complete and precise time breakdown for the analysis of drilling and flat time.

This innovative approach is the basis of the Integrated Drilling Data Discovery (ID3) system, developed by kwantis. ID3 manages one single big-data platform to integrate surface logging data with reporting information (e.g., daily drilling reports and bit reports) and measures lithology, trajectories, and other key data while drilling to create a complete set of drilling performance analyses.

The system is able to break down the drilling sequence to the most detailed activities (e.g., bit on bottom, reaming, circulating, or on slip) with a 5-seconds accuracy. The information regarding phases, troubles, and equipment are provided by the daily reporting and plotted on the common time or depth bases to create meaningful analytics on a single well or group of offset wells.

The applications of these analyses are multiple and provide new capabilities at any stage of the well life cycle: planning, operating, or post-well analysis.
Technology Focus: Offshore Facilities (February 2018)
Authors: Elkins Mark
Published: January 2018

Technology Focus

Welcome to the Offshore Facilities feature in this month’s JPT. The three papers featured in this section were selected out of 141 collected covering various elements of offshore-facilities design, construction, installation, operation, and inspection.

The first paper covers the design, fabrication, transportation, installation, and startup of a floating production, storage, and offloading (FPSO) vessel in an ultradeepwater location in the Gulf of Mexico.  The vessel is connected to production and an export gas pipeline with a disconnectable buoy, which allows the FPSO vessel to sail off location in the event of a hurricane. The paper highlights the design features of the installation and some of the project-execution challenges.

The second paper describes a technology-development effort to monitor the mechanical integrity of flexible risers in offshore use through a technique called Monitoring Based on Optical Fiber Attached Directly on Armor Wires, or MODA.  This is an interesting approach to assess the integrity of the tensile armor at the top section of flexible risers, and the authors summarize years of work in developing the required hardware and data processing.

The final paper covers field work performed to ascertain the functional capacity limits of existing equipment on a deepwater platform in excess of the original nameplate limits. It is fairly typical of the industry that, sometime after process facilities are installed, an opportunity to increase production is presented and the engineer must divine the absolute limits of the equipment. This paper presents a nice narrative of one company’s work to answer this question.

I hope you enjoy reading these papers.

Recommended additional reading at OnePetro: www.onepetro.org.

OTC 27526 General Design of Lean MEG Storing in the Jacket Legs on Liwan Gas Field of South China Sea by Zhi Xia, China National Offshore Oil Corporation, et al.

OTC 27719 Fixed Platforms at Aging Oil Fields—Feasibility Study for Reuse to Wind Farms by J.C. Barros, Genesis Oil and Gas, et al.

OTC 27742 Enabling Materials and Corrosion Technologies for Optimizing Offshore Developments by Eric J. Wright, ExxonMobil Production Company
Field Trials Help Boost Processing Capacity of Offshore Facility Above Nameplate Limit
Authors: Wilson Adam
Published: January 2018

This article, written by Special Publications Editor Adam Wilson, contains highlights of paper SPE 187129, “Demonstration of Processing-Capacity Enhancement on an Offshore Facility Through Systematic Field Trials,” by Neil Rodrigues, SPE, and Nikhil Joshi, SPE, Anadarko; Ricky L. Jagneaux, Nalco Champion; and Kashyap P. Kapadia, Moulinex Business Services, prepared for the 2017 SPE Annual Technical Conference and Exhibition, San Antonio, Texas, USA, 9–11 October. The paper has not been peer reviewed.

The Constitution spar in the Gulf of Mexico has an original nameplate separation capacity of 70,000 BOPD and 200 MMscf/D of gas. Production potential from future developments is expected to exceed this limit. In order to maximize value, a systematic effort is under way to enhance the throughput of the facility. Field tests were performed with the goal of identifying any deficiencies that would inhibit the facility from reaching nameplate capacity and identifying areas of improvement that would allow the facility to process beyond this limit.

Facility Processing Overview

On the Constitution spar (Fig. 1), unprocessed fluids from the reservoir pass through production trains where bulk oil/gas and oil/water separation takes place. Train 1 consists of high-pressure (HP), intermediate-pressure (IP), and low-pressure (LP) oil separators, and Train 2 consists of HP oil, HP inlet gas, and LP oil separators. In Train 1, the HP and IP oil separators are two-phase vessels designed for gas/liquid separation and the LP oil separator is a three-phase vessel designed for both gas/liquid and oil/water separation. Similarly, in Train 2, the HP oil and HP inlet gas separators are two-phase vessels and the LP oil separator is a three-phase vessel.

The oil from the LP oil separators in Trains 1 and 2 is commingled and passes through the treater, which is designed to condition the oil to meet export-oil specifications for Reid vapor pressure and basic sediment and water (BS&W). The water from the LP oil separators in Trains 1 and 2 passes through hydrocyclones and then to a flotation unit, designed to remove any free oil and impurities to maintain overboard-discharge-water specifications.

The gas from the production separators is compressed through a three-stage flash gas compressor. It then passes through a dehydration unit that consists of a gas cooler, scrubber, glycol contactor, and glycol-regeneration skid. The purpose of these vessels is to remove any entrained hydrocarbons and water to meet export-gas specifications.
Well-Performance Study Integrates Empirical Time/Rate and Time/Rate/Pressure Analysis
Authors: Carpenter Chris
Published: January 2018

This article, written by JPT Technology Editor Chris Carpenter, contains highlights of paper SPE 179119, “A Well-Performance Study of Eagle Ford Gas Shale Wells Integrating Empirical Time/Rate and Analytical Time/Rate/Pressure Analysis,” by A.S. Davis and T.A. Blasingame, Texas A&M University, prepared for the 2016 SPE Hydraulic Fracturing Technology Conference, The Woodlands, Texas, USA, 9–11 February. The paper has not been peer reviewed.

The purpose of the complete paper is to create a performance-based reservoir characterization by use of production data (measured rates and pressures) from a selected gas-condensate region within the Eagle Ford Shale. The authors use modern time/rate (decline-curve) analysis and time/rate/pressure (model-based) analysis methods to analyze, interpret, and diagnose gas-condensate well-production data. Reservoir and completion properties are estimated; these results are then correlated with known completion variables. The time/rate and time/rate/pressure analyses are used to forecast future production and to estimate ultimate recovery.

Production-Analysis Work Flow

The data required for the completion of the proposed methodology include well-history files, daily-rate and flowing-pressure measurements, and laboratory pressure/volume/temperature (PVT) and fluid-analysis reports. The following diagnostic plots are used to identify potential errors or abnormalities in the production data:

Rate/pressure/time plot (semilog)

Productivity-index/time plot (semilog)

Productivity-index/time plot (log-log)

Rate/cumulative-production/time plot (log-log)

Pressure/rate correlation plot (Cartesian)

Rate/pressure/cumulative-production plot (semilog)

In addition to checking the integrity and correlation of production data, the authors also use the following diagnostic plots to establish the reservoir model and flow regimes:

Log-log plot

Blasingame plot (log-log)

Productivity-index/normalized-cumulative-gas-production plot (log-log)

Note that, for the diagnostic plots, an incorrect estimate of the initial reservoir pressure will yield plots that show skewed trends or clumping or scattering of data points, particularly at early production times.

On the basis of the information gathered from the diagnostic plots and well-history files, nonrepresentative production data points that are likely the result of nonreservoir effects or operational changes such as well-cleanup effects, liquid loading, well recompletions, well workovers, or choke changes are filtered. The diagnostic plots are prepared with the filtered production data to identify the flow regimes experienced by a given well. It is of primary importance to recognize if the well is still in transient flow or has already entered boundary- dominated flow because it allows determination of which of the time/rate relation models is appropriate for the given production data.
Catalog of Well-Test Responses in a Fluvial Reservoir System
Authors: Carpenter Chris
Published: January 2018

This article, written by JPT Technology Editor Chris Carpenter, contains highlights of paper SPE 180181, “Catalog of Well-Test Responses in a Fluvial Reservoir System,” by J.L. Walsh and A.C. Gringarten, Imperial College London, prepared for the 2016 SPE Europec featured at the 78th EAGE Conference and Exhibition, Vienna, Austria, 30 May–2 June. The paper has not been peer reviewed.

Well-test analysis in fluvial reservoirs remains a challenge because of the depositional environment conducive to significant internal heterogeneity. Analytical models used in conventional analysis are limited to simplified channel geometries and, therefore, fail to capture key parameters such as sand-body dimensions, orientations, and connectivity, which can affect control-fluid flow and pressure behavior. The complete paper aims at a better understanding of the effect of channel content in complex fluvial channel systems on well-test-derivative responses.

Methodology

Geological Modeling. 3D geological models with a centrally located well were generated and populated with varying fluvial geologies. A 6950-m×6950-m×300-ft geological model was set up that allowed the averaging effects of the heterogeneities and the reservoir boundaries to be visible on the derivative at late times.

Modeling the geology of a fluvial system is challenging because of changes in channel amplitude, amalgamation, and other processes through geological times, which yield highly variable distribution and shapes of fluvial deposits. Field X was modeled as isolated elliptical sand bodies and channel bodies, with sand-body dimensions of 105 m (width)×420 m (length)×5 ft (thickness) for the base case. The sand and channel bodies are schematically represented in Figs. 1 and 2. Object-oriented modeling was used instead of stochastic, sequential indicator simulation and Gaussian simulation to retain control over the modeling parameters. 

Numerical Simulation. The corresponding pressure and derivative dynamic responses were generated using a proprietary finite-element simulator with a uniform grid and a fine local grid refinement (LGR) around the wellbore. The fluid was black oil at a reservoir pressure greater than the saturation pressure, and the relative permeability to water was low enough to limit water movement within the model.

Results and Discussion of Base-Case Model

A drawdown of 115 years was simulated for a geological model 6950 m×6950  m×300 ft with a cell size of 50 m×50 m×5 ft in the x, y, and z directions, respectively (total cell count without LGR=1,159,260), with a fine Cartesian LGR around the wellbore to reduce numerical artifacts around the wellbore (total cell count with LGR=1,327,200). The model consists of two facies. All simulations were performed without including wellbore dynamics or mechanical skin.
Barriers to effective value chain management in developing countries: new insights from the cotton industrial value chain
Authors: Mapanga Arthur , Ogutu Miruka Collins , Mavetera Nehemiah
Published: January 2018

A rigorous and extensive application of the value chain management (VCM) has become the vogue in modern day business practices and processes. However, due to the complex and multidimensional nature of value chains, achieving efficient and effective value chain management in real value chains remains a major conundrum for practitioners. Many unknown barriers continue to impede effective and efficient value chain management in developing countries’ industrial value chains. The purpose of this study was to find out the common barriers to effective value chain management in a developing country’s industrial value chains using evidence from the cotton industry in Zimbabwe. The analysis was based on survey data sets obtained from 157 purposively sampled experts from the cotton industry value chain in Zimbabwe. Exploratory factor analysis was used to find the barriers to effective value chain management. The results revealed both architectural and governance barriers to effective value chain management. The findings also presented major policy implications for industrial value chains in the developing countries and also indicated areas for further robust research founded on a broader data set from other developing countries’ industrial chains as a way of validating the findings of this study.
Biosorption of cationic dyes by Pará chestnut husk (Bertholletia excelsa)
Authors: Georgin Jordana , Marques Bianca Silva , Peres Enrique Chaves , Allasia Daniel , Dotto Guilherme Luiz
Published: January 2018

Pará chestnut husk (Bertholletia excelsa) (PCH), an agro-industrial waste largely generated in Brazil, was employed as a low-cost and efficient biosorbent to remove the cationic dyes Crystal Violet (CV) and Methylene Blue (MB) from aqueous media. PCH presented an amorphous structure containing carboxylic acids, esters, ketones and aldehydes on the surface. Non-porous and irregular particles were also observed. For both dyes, the biosorption capacity was favored under acid conditions. Equilibrium was attained within 40 min at 25 °C with a PCH dosage of 0.5 g L−1. The biosorption kinetic curves were satisfactory explained by the pseudo-first-order model. The Freundlich model was best for representing the equilibrium curves. The maximum biosorption capacities were 83.6 and 83.8 mg g−1 for CV and MB, respectively. PCH was efficient for treating a simulated textile effluent containing several dyes and chemicals, achieving a color removal of 90%. In this way, PCH can be considered as an option for treating colored effluents containing textile dyes.
Beneficial Effects of N-acetylcysteine and N-mercaptopropionylglycine on Ischemia Reperfusion Injury in the Heart
Authors: Bartekova Monika , Barancik Miroslav , Ferenczyova Kristina , Dhalla Naranjan S.
Published: January 2018

Background:

Ischemia-reperfusion (I/R) injury of the heart as a consequence of myocardial
infarction or cardiac surgery represents a serious clinical problem. One of the most prominent
mechanisms of I/R injury is the development of oxidative stress in the heart. In this regard,
I/R has been shown to enhance the production of reactive oxygen/nitrogen species in the heart
which lead to the imbalance between the pro-oxidants and antioxidant capacities of the endogenous
radical-scavenging systems.

Objectives:

Increasing the antioxidant capacity of the heart by the administration of exogenous antioxidants
is considered beneficial for the heart exposed to I/R. N-acetylcysteine (NAC) and Nmercaptopropionylglycine
(MPG) are two sulphur containing amino acid substances, which belong
to the broad category of exogenous antioxidants that have been tested for their protective potential
in cardiac I/R injury.

Observations:

Pretreatment of hearts with both NAC and MPG has demonstrated that these agents
attenuate the I/R-induced alterations in sarcolemma, sarcoplasmic reticulum, mitochondria and
myofibrils in addition to improving cardiac function. While experimental studies have revealed
promising data suggesting beneficial effects of NAC and MPG in cardiac I/R injury, the results of
clinical trials are not conclusive because both positive and no effects of these substances have been
reported on the post-ischemic recovery of heart following cardiac surgery or myocardial infarction.

Conclusion:

It is concluded that both NAC and MPG exert beneficial effects in preventing the I/Rinduced
injury; however, further studies are needed to establish their effectiveness in reversing the
I/R-induced abnormalities in the heart.
Design, Synthesis and Biological Evaluation of Uracil Derivatives as Novel VEGFR-2 Inhibitors
Authors: Liang Jingwei , Li Xinyang , Yang Su , He Xin , Wang Mingyang , Meng Fanhao
Published: January 2018

Backgound: Vascular endothelial growth factor receptor-2 (VEGFR-2) plays a crucial role in the
process of cancer angiogenesis. Type I inhibitors constitute the major ATP-competitive inhibitors and recognize
mainly the active conformation of VEGFR-2. Meanwhile, type II inhibitors recognize the inactive DFG (Asp-
Phe-Gly)-out conformation of VEGFR-2, which was a more promising approach for drug intervention.

Methods:

According to the lead compound of uracil skeleton, being screened out by structure-based virtual
screening, a series of uracil derivatives were designed and synthesized. Results: The inhibitory activities were
investigated against VEGFR-2 kinase in vitro. The results turned out that series A performed moderate inhibitory
activities, especially compound A4 exhibited the most potent inhibitory activity (IC50=0.029 µM).

Conclusion:

The lead compound was screened out by structure-based pharmacophore models, then two series
of uracil derivatives were synthesized according to it and evaluated for their inhibitory activities against
VEGFR-2. In this study, not only a potential inhibitor has been discovered, it also demonstrates the feasibility
of structure-based virtual screening method for drug discovery.
Potential Pharmacological Inhibitors of Pim Kinase Under Clinical Trials
Authors: Jeyapal Gomathi P. , Chandrasekar Moola J.N. , Krishnasamy Rajendiran , Selvaraj Jubie , Mohammad Manal , Nanjan Moola J.
Published: January 2018

Pim kinases, also known as Serine/Threonine kinases, are intensively studied protein drug targets in
cancer research. They play crucial role in the regulation of signal transduction cascades that promote cell survival,
proliferation and drug resistance. Pim kinases are overexpressed in several hematopoietic and solid tumors
and support in vitro/in vivo malignant cell growth and survival, through cell cycle regulation and inhibition of
apoptosis. Pim kinases do not have an identified regulatory domain, as they are constitutively active. They appear
to be critical downstream effectors of a number of oncoproteins. When overexpressed, they mediate drug
resistance to agents such as Rapamycin. X-ray crystallographic studies reveal that unlike other kinases, Pim
kinases have a hinge region, which forms a unique binding pocket for ATP, offering a target for a large number
of potent small-molecule Pim kinase inhibitors. Combination therapy of Pim kinase inhibitors with chemotherapeutic
and other kinase modulators seems to produce an additive cytotoxic effect in cancer cells. Though clinical
trials have been carried out on the first Pim inhibitory agent, SGI-1776, no concept data could be generated due
to its early withdrawal. However, it has helped in accelerating the discovery of several novel Pim inhibitors in
recent years. Current research on Pim kinase is expected to lead to a new generation of potent Pim kinase inhibitors
with appropriate pharmacological profiles suitable for human cancer therapy in the near future. Herein, we
review the synthetic route and mechanistical studies of Pim kinase inhibitors which are currently in human trials.
Palyno-taxonomic study of some members of Malvaceae in Purba Medinipur, West Bengal, India.
Authors: Maity Sandip Kumar , Patra Arjun , Pal Bikram , Malakar Arati
Published: January 2018

The Malvaceae is a large family of about 243 genera and 4225 species with medicinal and gardening importance. Palynological observations were carried out of 9 species collected from different localities of Purba Medinipur District during the period of February 2016 to December 2017. The present study reveals the pollen morphological characteristics, especially pollen shape classes like Oblate (1 species), Oblate-spheroidal (4 species), Sub-prolate (1 species) and Per-oblate (3 species) with diameter ranges between 35 µm (Urena lobata L.) to 115 µm (Malvaviscus arboreus Cav.). Pollen morphology is one of the most significant tool for the taxonomic study as well as systematics of plant taxa.
Estimation of correlation coefficient study of some quantitative traits in wheat
Authors: Shyam Chitralekha , P.K. Chandrakar , N.K. Rastogi , Banjare Umakant , Densena Manoj
Published: January 2018

Wheat is the world’s most important crop that excels all other cereal crops both in area and production, thereby providing about 20.0 per cent of total food calories for the people of the world. The experiment was conducted at Research Farm, IGKV, Raipur during Rabi 2013-14. Chhattisgarh is located in the east - central part of the country between 17°14’N and 24°45’ N latitudes and 73°30’ E and 84°15’ E longitudes, whereas Raipur the capital of the Chhattisgarh state, lies at 21°16’ N latitude and 81°36’ E longitude with an altitude of 289.60 meters above sea level. All Twenty two genotypes were grown in Randomized Block Design with three replications. Correlation studies give a clear picture of characters association which is generally due to linkage, pleiotrophy, physiological association in developmental and biochemical pathway The phenotypic and genotypic correlations were determined among seed yield and its components in possible character combinations. In Correlation coefficient analysis, seed yield per plant exhibited highly significant positive correlations with number of seeds per spike and number of seeds per plant at both genotypic and phenotypic levels, whereas number of seeds per spikelet at the genotypic level.
Heterosis in relation to genetic diversity in pearl millet (Pennisetum glaucum L.)
Authors: N. Swami Naidu , S.K. Ghosh , Mallikarjuna Kokkanti
Published: January 2018

In the advent of failure of some transgenics at the field level and concerns due to biosafety and bioethical issues, there much thrust on natural plant genetic diversity as a means of adaptive value. Plant breeding basing on natural genetic diversity has gained momentum along with marker assisted breeding technologies for increased production and sustenance to various kinds of stresses. In the present investigation, divergence classification (DC) – a method devised by Arunachalam and Bandyopadhyay (1984) were used to classify 28 Pearl millet genotypes to draw a limit of parental diversity in expressing maximum heterosis. Mahalanobis D2 (D2 Values) statistic was used to measure the genetic diversity and then the genotypes were classified in to four divergence classes based on mean and standard deviation of all D2 values. According to divergence classification DCI involved most distantly and DCIV the most closely related parents where as DCII and DCIII involved the medium divergent parents. A scoring system was adopted to work out the relative order of importance of the divergence classes. The overall scores for each divergence classes based on the proportion of crosses (q) showing significant heterosis (heterosis over better parent) in desired direction and mean (y) of such crosses for ten characters were carried out to rank the divergence classes. According to the scoring system, the most desirable class would be with the lowest total score. Results clearly showed the superiority of class DCIII followed by DCII, as both the classes received low overall score and maximum number of heterotic cross combinations. In conclusion it can be said that divergence classification appears to be effective in clubbing the pearl millet genotypes for parental diversity and suggested that pearl millet parents with intermediate diversity would be used to produce heterotic cross combination.
Standardization of Agrobacterium mediated genetic transformation in Indica rice cv BPT-5204
Authors: G. Anuradha , Gandikota Mahendranath , T. Krishnakanth Yadav , P. Jagadish , M. Raghurami Reddy , S.M., Balachandran , E.A. Siddiq , K.N. Yamini
Published: January 2018

The BPT-5204 genotype from Indica rice cultivar (cv) is recalcitrant and showed low transformation frequency compare to japonica rice cv. Here we have optimized the efficient transformation protocol to minimize the time scale and enhance the transformation frequency by altering the key parameters like, acetosyringone (AS) concentration, optical density of bacterial culture and co-cultivation time. Highly proliferated 21 days old Scutellum derived embryogenic calli were infected with Agrobacterium tumefaciens harbouring pCAMBIA2300-Ds-En-Bar binary vector. T-DNA contains tetrameric CaMV35S enhancer elements along with bar gene which embedded between the transposable Ds element. At 0.5 OD600nm of Agrobacterium culture and co-cultivation for 2 days on MS co-cultivation medium containing 100 μM acetosyringone proved to be optimal and attained 6.2 % of transformation efficiency. The transformed calli and regenerated plantlets were proliferated on Murashige and Skoog (MS) medium containing phosphinothricin (PPT). Polymerase chain reaction (PCR) confirmed that intact T-DNA was successfully integrated in the rice genome. This protocol can be employed to develop transgenic rice plants with gain of functional mutagenesis.
Post‐Graduation Effects of an Advocacy Engagement Project on Alumni of a Dental Hygiene Program
Authors: Bono Leciel K. , Rogo Ellen J. , Hodges Kathleen , Frantz Alan C.
Published: January 2018

The aim of this study was to investigate advocacy actions of dental hygiene program alumni who had completed a Legislative Advocacy Project (LAP) when they were students in the undergraduate or graduate program. Five variables were assessed: participation, frequency, perceived barriers, engagement, and mentorship. Alumni of the undergraduate and graduate programs were compared regarding frequency of and barriers encountered to legislative advocacy actions. A descriptive‐comparative research design was used with quantitative and qualitative analysis. A convenience sample of 157 alumni who had completed a seven‐week LAP at Idaho State University between 2008 and 2013 were invited to complete a 52‐item author‐designed online questionnaire in 2015. The response rate was 41.4%. The results showed a significant difference for participation prior to and after the LAP (df=12, X2=28.28, p=0.005). Most respondents, however, did not participate in legislative actions. There was a significant difference between the two groups for two frequency items: subscribing to online listservs (p=0.001) and contacting political representatives or staff (p=0.003). The three greatest barriers were time, financial resources, and testifying. The analysis found a significant difference between the two groups for the barrier of interest in advocating (p=0.05). In the qualitative analysis, themes emerged about engagement factors (collective efforts and advocacy commitment) and mentorship (mentoring experiences). Advocacy actions after graduation improved, but implementation of actions was challenging due to competing barriers. The results of this study may be useful in identifying key components of advocacy education that should be part of training programs.
Dental Student and Faculty Perceptions of Uncivil Behavior by Faculty Members in Classroom and Clinic
Authors: Ballard Richard W. , Hagan Joseph L. , Fournier Suzanne E. , Townsend Janice A. , Ballard Mary B. , Armbruster Paul C.
Published: January 2018

Uncivil behavior by a faculty member or student can threaten a classroom environment and make it less conducive to learning. The aim of this study was to explore faculty behaviors that dental faculty and students perceive to be uncivil when exhibited in the classroom and clinic. In 2015, all faculty, administrators, and students at a single academic dental institution were invited to participate in an electronic survey that used a five‐point Likert scale for respondents to indicate their agreement that 33 faculty behaviors were uncivil. Response rates were 49% for faculty and 59% for students. Significant differences were found between student and faculty responses on 22 of the 33 behavioral items. None of the three category composite scores differed significantly for students compared to faculty respondents. The category composite scores were not significantly associated with gender, ethnicity, or age for faculty or students. Overall, this study found significant differences between students and faculty about perceived uncivil faculty behaviors, though not for categories of behaviors.
Objetos de aprendizaje en la educación virtual: una aproximación en bibliotecología
Authors: GARDUÑO V. ROBERTO
Published: January 2018

EN LOS INICIOS DEL SIGLO XXI LA ENSEÑANZA DE LAS DISCIPLINAS EN TODOS SUS NIVELES Y MODALIDADES HA SIDO AFECTADA POR LOS PROGRESOS DERIVADOS DE LA INVESTIGACIÓN CIENTÍFICA Y TECNOLÓGICA. LA INNOVACIÓN EN TECNOLOGÍA, LA PRIVATIZACIÓN Y COMERCIALIZACIÓN DEL CONOCIMIENTO Y LA DEMANDA SOCIAL CRECIENTE DE PROPUESTAS EDUCATIVAS, HAN OCASIONADO QUE LAS UNIVERSIDADES INCIDAN EN PROGRAMAS DE DESARROLLO SUSTENTABLE RELACIONADO CON LA PRESTACIÓN DE SERVICIOS EDUCATIVOS. ASÍ, LA EDUCACIÓN VIRTUAL UTILIZA LA INFORMACIÓN, EL CONOCIMIENTO Y LOS MEDIOS PARA PROPICIAR DIÁLOGOS DIDÁCTICOS MEDIADOS POR EL PROCESO DE COMUNICACIÓN ENTRE LOS ACTORES DE LA FORMACIÓN VIRTUAL. EN LA ACTUALIDAD EL OBJETO DE APRENDIZAJE SE SITÚA COMO FENÓMENO DE INVESTIGACIÓN EMERGENTE PARA LAS DISCIPLINAS DEBIDO A LA PROSPECTIVA QUE SE ESPERA DEL PROPIO OBJETO EN LA EDUCACIÓN DEL PRESENTE PARA LA EDUCACIÓN EN LÍNEA, LOS OBJETOS DE APRENDIZAJE Y LAS PERSPECTIVAS DE LOS OBJETOS DE APRENDIZAJE EN LA ENSEÑANZA DE LA DISCIPLINA BIBLIOTECOLÓGICA. SIGLO. POR LO ANTERIOR, SE REFLEXIONA AQUÉL A PARTIR DE LOS SIGUIENTES ASUNTOS: LO VIRTUAL EN LA FORMACIÓN, LA GENERACIÓN DE CONTENIDO PARA LA EDUCACIÓN VIRTUAL, LA TENDENCIA EMERGENTE EN EL DESARROLLO DE OBJETOS DE APRENDIZAJE PSICOPEDAGOGÍA, LOS ESTÁNDARES EDUCATIVOS; LA INVESTIGACIÓN EN PROCESO RELACIONADA CON OBJETOS DE APRENDIZAJE EN LA ENSEÑANZA DE LA DISCIPLINA BIBLIOTECOLÓGICA
Tendencias actuales de citación en los trabajos de investigación filosófica
Authors: MUÑOZ-ALONSO LÓPEZ GEMMA
Published: January 2018

EL ARTÍCULO PROPONE UNIFICAR LOS CRITERIOS PARA CITAR Y ELABORAR BIBLIOGRAFÍAS EN LA INVESTIGACIÓN EN FILOSOFÍA Y EN CIENCIAS HUMANAS. SE ANALIZAN LAS VENTAJAS Y LOS INCONVENIENTES DEL SISTEMA TRADICIONAL Y DEL SISTEMA HARVARD.
Collaboration between Canadian Grantmaking Foundations: The Expression of an Increasingly Ambitious and Strategic Philanthropic Sector?
Authors: Glass Juniper , Pole Nancy
Published: January 2018

This article critically discusses the practice of foundation collaboration in Canada and describes the context, vehicles, and forms that it takes. It is based on data from interviews with 23 key informants and a literature review of over 100 publications from grey and scholarly literature. Over the last decade, Canadian grantmaking foundations appear to be working together more often, motivated by goals of information sharing, coordination, impact, and risk mitigation. In Canada, as elsewhere, this growing practice is closely related to the trend toward strategic philanthropy, in which foundations position themselves as agents of change. The article raises cautions and criticisms about foundation collaboration, related to considerations of strategic and cultural fit as well as to existing challenges concerning philanthropy’s power and legitimacy in society.L’article propose de faire un examen critique des pratiques de collaboration entre fondations subventionnaires au Canada, qui représentent un domaine jusqu’ici peu exploré dans la recherche scientifique. À partir d’entretiens avec 23 informateurs clés et une recension d’écrits scientifiques et non scientifiques, l’article décrit le contexte, les chemins d’émergence et les formes que prennent ces pratiques de collaboration. Au cours de la dernière décennie, les pratiques de collaboration entre fondations subventionnaires semblent afficher une progression au Canada. Des fondations participantes indiquent être motivées par le désir de soutenir le développement des connaissances, de mieux coordonner leurs efforts, d’accroitre l’efficacité ou l’impact de leurs interventions et d’en atténuer les risques. Au Canada comme ailleurs, le développement des pratiques de collaboration entre fondations est lié à l’influence du courant de la philanthropie « stratégique » qui incite les fondations à assumer une posture plus affirmée d’agent de changement. L’article partage également des réflexions critiques au sujet de ces pratiques. Entre autres, il arrive que les organisations participantes doivent composer avec des défis de compatibilité culturelle et stratégique. De plus, ces pratiques se confrontent à des débats existants concernant le pouvoir exercé par les fondations philanthropiques et leur légitimité en tant qu’acteurs sociaux.
O perfil e a trajetória dos bacharéis e tecnólogos da área de gerenciamento e administração: estudo comparativo
Authors: Giordano Prof. Dr. Carlos Vital , Matos Sandra , Gonçalves Luiz Cláudio
Published: January 2018

A presente pesquisa apresenta como tema os Bacharéis e Tecnólogos da área de Gerenciamento e Administração graduados em instituições de ensino superior privadas do Estado de São Paulo, que utilizam o custo praticado em suas mensalidades para atrair novos discentes. Objetiva comparar o perfil e a trajetória de profissionais que concluíram Cursos de Bacharelado e, igualmente, aqueles que concluíram Cursos Superiores de Tecnologia na área de Gerenciamento e Administração, entre os anos de 2004 e 2015. Consideraram-se validos apenas questionários de respondentes graduados em instituições que anunciavam valores de mensalidades próximos ao salário mínimo de 2016, ou ofertavam bolsas de estudo e descontos para atrair novos estudantes. Os resultados comprovaram que o grau acadêmico de ensino superior promove diferenciação na carreira dos egressos da área de Gerenciamento e Administração.
Ingresos en hospitalización a domicilio directamente desde el servicio de urgencias: una alternativa eficaz y segura
Authors: Dopico Santamariña Leticia María
Published: January 2018

Objetivo: Analizar el perfil de pacientes con patología infecciosa que ingresan en HaD tras captación en Urgencias, soporte y calidad asistencial.Método: Estudio observacional retrospectivo. Variables: características del paciente, infección, tratamiento, parámetros de hospitalización e indicadores de calidad.Resultados: Incluidos 255 pacientes con edad media 71 años (48.63% varones; 51.37% mujeres) e índice medio de Charlson 4.91. Diagnósticos más frecuentes: infección urinaria (25.10%) y respiratoria (24.71%), sin identificación microbiológica en 62.75%. Aislamiento más frecuente: E.coli (21.32%) documentándose 10.20% bacteriemia  y 14.51% criterios de sepsis. Todos necesitaron antibioterapia parenteral con media 6.5 días, siendo más empleados carbapenems (34.31%). Estancia media en Urgencias 21 horas y en HaD 7 días. Se registraron 9.41% de complicaciones obteniéndose tasa de reingreso 2.75%.Conclusiones: Tras estancia corta en Urgencias es posible el manejo eficaz de infecciones con criterios variables de gravedad y alta comorbilidad, dando el soporte necesario desde HaD, sin aumentar complicaciones ni reingresos.
Electrochemical synthesis of poly(2-methyl aniline): electrochemical and spectroscopic characterization
Authors: Buzarovska Aleksandra , Arsova Irena , Arsov Ljubomir
Published: January 2018

Poly(2-methyl aniline) or poly(ortho-toluidine), as ring substituted
derivative of aniline, has been synthesized electrochemically in various
concentrations of H2SO4 and HCl, and then characterized by cyclic
voltammetry, as well as by impedance and Raman spectroscopy. The cyclic
voltammograms of poly(o-toluidine) and poly(aniline) show that the
electrochemical polymerization of these two polymers proceeds by almost
identical mechanisms. The Raman spectroscopical measurements suggest that
the redox reactions of poly(aniline) and poly(o-toluidine) are similar in
the potential range between -0.2 and 0.7V vs. SCE. The impedance
measurements showed that the conductivity of poly(o-toluidine) is an order
of magnitude lower than that of the corresponding poly(aniline) form.