bluuebunny/crossref_metadata_2025 huggingface dataset:
CDK9 as an Appealing Target for Therapeutic Interventions
Authors: Eyvazi Shirin , Hejazi Mohammad Saeid , Kahroba Homan , Abasi Mozghan , Zamiri Reza Eghdam , Tarhriz Vahideh
Published: October 2018

Cyclin Dependent Kinase 9 (CDK9) as a serine/threonine kinase belongs to a great number of CDKs. CDK9 is the main core of PTEF-b complex and phosphorylates RNA polymerase (RNAP) II besides other transcription factors which regulate gene transcription elongation in numerous physiological processes. Multi-functional nature of CDK9 in diverse cellular pathways proposes that it is as an appealing target. In this review, we summarized the recent findings on the molecular interaction of CDK9 with critical participant molecules to modulate their activity in various diseases. Furthermore, the presented review provides a rationale supporting the use of CDK9 as a therapeutic target in clinical developments for crucial diseases; particularly cancers will be reviewed.
Research Progress of Diphenyl Urea Derivatives as Anticancer Agents and Synthetic Methodologies
Authors: Wu Yi-Cong , Ren Xin-Yue , Rao Guo-Wu
Published: October 2018

The malignant neoplasm, which is recognized as cancer, is a serious threat to human health and frequently-occurring disease. Diphenylurea, an important link structure in the design of active substance for treating cancer due to its near-perfect binding with certain acceptors, has demonstrated many activities against several human cancer cell lines. Various novel compounds with diphenyl urea as anticancer agents were constructed with the successful development of sorafenib. Diphenylurea is utilized to treat cancer by inhibiting cell signaling transduction, such as RAS-RAFMEK- ERK signaling pathway and PI3K-Akt-mTOR pathway. In addition, this structure inhibits tumor cell growth by inhibiting receptor tyrosine kinases multiply, such as Vascular Endothelial Growth Factor Receptors (VEGFRs), Platelet-Derived Growth Factor Receptors (PDGFRs), Epidermal Growth Factor Receptors (EGFRs). It regulates the pH value in cells by inhibiting CAIX/XII and to achieve cancer therapeutic effect. Besides, the diphenyl urea structure is applied to the synthesis of reagents like Aurora kinases inhibitors and HDAC inhibitors that affect cell division and differentiation to treat cancer. To reach the goal of treating tumor, this structure is also used as a DNA-directed alkylating agent by affecting the expression of genes. An application of the most representative diphenyl urea derivatives as antitumor agents is summarized in this review, focusing on their mechanisms bound to the targets. Meanwhile, the progress of researches on methods of synthesizing diphenyl urea derivatives is provided.
Medical Perspective of Childhood Marriage in Nigeria: Body of Evidence from 2013 Nigeria Demographic and Health Survey
Authors: Alayande Audu , Bello-Garko Bahijjatu , Abubakar Zubaida , Kagara Hafsat , Nuhu Islamiyat A.
Published: October 2018

Background:

Available data from South Asia and sub-Saharan Africa indicates that 12%
and 34% of girls were married at age 15years and 18years respectively. This practice of child marriage
may debar countries from achieving the Sustainable Development Goals.

Objective: To extract and present disaggregated indices in the 2013 Nigeria Demographic and
Health Survey (NDHS) on the effect of child marriage on health.

Method:

This desk review study extracted disaggregated maternal and child health indices on married
females aged 15-19 years from the 2013 NDHS.

Results:

The result showed that married females aged 15-19 years were short, thin, and least likely
to receive prophylactic Vitamin A dose postpartum and deworming medication at last pregnancy.
Also, while awareness for Family Planning (FP) was high, its utilization was poor at only 1.2%.
Their Antenatal clinic attendance, facility delivery, skilled birth attendance at delivery and post
natal service utilization were lowest.

Similarly, mortality of children under 5 was highest amongst these mothers. Although violence
during pregnancy was highest amongst this group, nevertheless more than 20% of them agreed that
the practice of female circumcision should be continued.

Conclusion:

These findings depict some of the negative outcomes of child marriage on maternal
and child survival which require integrated multisectoral interventions to ensure that all girls have
access to timely sexual reproductive health services and information.
β-Sitosterol Oxides From the Dried Stem of Salix gilgiana Inhibit the Proliferation of HL-60 Leukemic Cells
Authors: Oyama Manami , Tokiwano Tetsuo , Ota Hiromi , Mizuno Kouichi , Oh Keimei , Kawaii Satoru , Yoshizawa Yuko
Published: October 2018

Background:

Salix gilgiana is a deciduous tree that grows in northern Japan, the Korean
peninsula, eastern Russia along the Ussuri River, and northeast China. The stem of this tree is dried and
consumed orally as a folk medicine. Our intensive screening of various plant materials found that the
MeOH extract of its dried stem exhibited significant antiproliferative activity against HL-60 leukemic
cells with an IC50 of 16 ppm. We systematically investigated the biologically active compounds of the
MeOH extract of the dried stem of S. gilgiana.

Methods:

The MeOH extract of S. gilgiana dried stem was fractionated by a repeated chromatography
monitored by antiproliferative activity against HL-60 leukemic cells. Five active compounds were isolated
and the structures were elucidated by MS, 1H- and 13C-NMR spectroscopy, and X-ray analysis.

Results:

The active compounds were identified as 7-ketositosterol (I), 7β-hydroxysitosterol (II), 7α-
hydroxysitosterol (III), (4-hydroxyphenyl)ethanol (IV), and (4-hydroxyphenyl)propan-1-ol (V). The
strongest activity was found for 7α-hydroxysitosterol (III), with an IC50 of 8.4 µM. This is the first
report of the isolation of these compounds from S. gilgiana.

Conclusion:

Five compounds were isolated by a repeated chromatography under the guidance of antiproliferative
bioassay using HL-60. The structures were identified as three β-sitosterol oxides and two
phenolic compounds. Since Salix species, namely, willow trees, have beneficial characteristics including
rapid growth, easy cloning, and resistance to high humidity and dryness, they may be utilized as a relatively
inexpensive tool for the efficient production of useful bioactive materials.
An Integrated Chikungunya Virus Database to Facilitate Therapeutic Analysis: ChkVDb
Authors: Narang Priya , Dangi Mehak , Sharma Deepak , Khichi Alka , Chhillar Anil Kumar
Published: October 2018

Background:

Chikungunya infection flare-ups have manifested in nations of Africa,
Asia, and Europe including Indian and Pacific seas. It causes fever and different side effects
include muscle torment, migraine, sickness, exhaustion and rash. It has turned into another,
startling general medical issue in numerous tropical African and Asian countries and is presently
being viewed as a genuine risk. No antiviral treatment or vaccine is yet available for this ailment.
The current treatment is centered just on mitigating its side effects.

Objective:

The objective was to encourage the study on this viral pathogen, by the development of
a database dedicated to Chikungunya Virus, that annotates and unifies the related data from
various resources.
associations while known disease-lncRNA associations are required only.

Method:

It undertook a consolidated approach for Chikungunya Virus genomic, proteomic,
phylogenetics and therapeutic learning, involving the entire genome sequences and their
annotation utilizing different in silico tools. Annotation included the information for CpG Island,
usage bias, codon context and phylogenetic analysis at both the genome and proteome levels.

Results:

This database incorporates information of 41 strains of virus causing Chikungunya
infection that can be accessed conveniently as well as downloaded effortlessly. Therapeutics
section of this database contains data about B and T cell Epitopes, siRNAs and miRNAs that can
be used as potential therapeutic targets.

Conclusion:

This database can be explored by specialists and established researchers around the
world to assist their research on this non-treatable virus. It is a public database available from
“www.chkv.in”.
Applying Energy-Equal Entropy of Wavelet Packet to Diagnose Circuit Breaker Faults
Authors: Mingliang Liu , Keqi Wang , Laijun Sun , Jianfeng Zhang
Published: October 2018

Aiming to better reflect features of machinery vibration signals of high-voltage (HV) circuit breaker (CB), a
new method is proposed on the basis of energy-equal entropy of wavelet packet(WP). First of all, three-layer wavelet
packet decomposes vibration signal, reconstructing 8 nodes of signals in the 3rd layer. Then, the vector is extracted with
energy-equal entropy of reconstructed signals. At last, the simple back-propagation (BP) neural network for fault diagnosis
contributes to classification of the characteristic parameter. This technology is the basis of a number of patents and patents
pending, which is experimentally demonstrated by the significant improvement of diagnose faults.
Power Quality Disturbance Location Method based on Cross-Feedback - Recursive Least Squares
Authors: Zhenhua Shao , Tianxiang Chen , Li-an Chen , Zelong Sun , Qichen Yan , Yanyan Guo , Xianliang Tao , Meirong Zheng
Published: October 2018

Due to the randomness and complexity of power quality disturbances, there is lack of mature and reliable detection
and analysing methods on power quality disturbance, especially in the construction site with the changeable operation
condition .In order to deal with the problems of non-stationary power quality signals and spectrum leakage, a new CF
Recursive Least Squares (CF-RLS) based on blind sources separation method is proposed in this paper. Furthermore the
way of converging on the proposed method is based on the maximum negative entropy gradient value. In this way, the
verges can be detected and the CF-RLS method can meet the requirement of signal reconstruction condition. With the
help of Matlab 7.0, the simulation cases with the power system harmonics with single disturbance and mixed disturbance
are discussed. Moreover the simulation results show that the harmonics parameters, including amplitudes, phase angles
and disturbance time, can be detected precisely. At last, the proposed method can completely meet the requirements of the
power quality disturbance location.
Property Analysis and Experimental Study of the Broadband Transmission-Line Transformer in Multimode Feed Network
Authors: Huawei Zhan , Weina Liu , Qiaoyu Li , Tingting Yan , Jie Zheng
Published: October 2018

Transmission-line transformers are circuits useful for microwave impedance matching applications due to their
broad operating bandwidth. Multimode feed network is composed of two substructures, which are constituted by the
transmission-line transformer. Beginning with the broadband transmission-line transformer with 4:1 impedance transformation,
supposing the currents on the two lines are not equal but opposite and with the application of two line transmission-
line theory, the current-voltage relationships of the asymmetrical (current) bifilar even transmission-line are obtained.
An equivalent model with mutual coupling between the subject transmission-lines has been proposed, and its characteristics
for impedance transformation have been analyzed. Also, a useful and effective analytic method for bifilar transmission-
line transformer has been proposed. The calculated values are in good agreement with the metrical values. So in real
application it can better improve the performance of the component and can be used more efficiently.
Experimental Study of the Electro-osmotic Dewatering in Hangbag
Authors: Ming-Jie CAO , Chun-Mei Ding , Ze-Dong Ren
Published: October 2018

In recent years, geotube began to be widely used in treatment of coastal reclamation projects. However, the dewatering of sludge in geotube is inefficient. In this paper, for improving dewatering efficiency and laying a basis for the further study of large-scale electro-osmotic dewatering in geotube, electroosmosis has been applied to silt dewatering experiments in small hangbag. By measuring the change of moisture content, electricity current, voltage and comparing with other experiments under different conditions, the following conclusions have been obtained: the electro-osmotic dewatering speed is much faster than the natural dewatering. The non-woven fabric bag is easier to dewater than the high strength fabric bag which is made by the company of Royal Tencate.
Editorial: Contributions to Earthquake Engineering
Authors: Perez Juan C.V. , Torija America B.
Published: October 2018

This special edition of “The Open Civil Engineering
Journal” presents a novel contribution to earthquake resistant
engineering through twelve research papers that address dif-ferent topics related to the study of the seismic vulnerability
of structures and infrastructures.
Cyclic Nonlinear Behavior of Pile-Deck Connections Using Structural Software Models
Authors: Sosa Diego , Caiza Pablo
Published: October 2018

A study of the cyclic nonlinear behavior of a pile-deck connection (characteristic of cargo port structures) is
performed using OpenSEES Concrete02 and Concrete07. Advantages and disadvantages are determined by comparison
with experimental results obtained in previous works. The parameters considered are: hysteretic energy, secant modulus,
and ductility at moderate and severe damage. This work seeks to define whether more complex calculations warrant additional
runtime. It is found that Concrete07, in fact, is much closer to the experimental results in terms of ductility. However,
the estimates of hysteretic energy and secant modulus are similar in both models. A better vulnerability estimate
would be obtained based on more accurate parameters such as ductility, hysteretic energy and secant modulus.
Circular Concrete-Filled Tubular Columns: State of the Art Oriented to the Vulnerability Assessment
Authors: Chacón Rolando
Published: October 2018

The vulnerability of framed structures has been analyzed until recently from two different perspectives: Structural
and socio-economical. For the sake of assessing the former, indexes and objective measurements have been proposed
in the literature. These indexes include relatively accurate assessments of the strength, ductility, energy absorption, fire,
blast response and resilience of the elements in order to define a higher-level structural magnitude. Similar approaches are
performed with the latter when it comes to assessing damage, economical aspects, social and other important factors.

On the other hand, concrete-filled tubes (CFT) have proven structurally efficient due to their relatively high strength-toweight
ratio. Considerably complete state-of-the-art reviews are available for these members when it comes to analyzing
their strength and overall or local buckling in static and/or dynamic responses. Reviews concerning important issues related
to the structural vulnerability of those members are, however, scarce.

In this paper, a state-of-the art dealing with the behavior of concrete-filled tubes is presented. The novelty of such approach
is to present research concerning CFT but, in this case, from a structural vulnerability perspective (not socioeconomical),
that is to say, summarizing references concerning seismic response, fire resistance, impact response and
other main characteristics that are further used when defining the aforementioned indexes. Relevant numerical, experimental
and theoretical studies presented in recent years are pinpointed as well as potential research trends.
Comparing Ground Motion Intensity, Root Mean Square of Acceleration and Time Duration from Four Definitions of Strong Motion
Authors: Echezuría Heriberto
Published: October 2018

Variation of strong motion intensity, root mean square of ground acceleration and time-duration in seconds obtained
from 83 accelerograms of 18 earthquakes with magnitudes between 5 to 7.7 were investigated considering four
definitions of strong section of accelerograms given by Vanmarcke-Lai; Bolt, Trifunac-Brady and McCaan-Shah. Strong
motion intensities were calculated for all definitions of strong duration. Even though, durations in seconds and root mean
square of ground acceleration values resulted quite different among the four definitions of strong sections, both durations
in seconds and root mean square of acceleration squared values tend to compensate each other to yield the same strong
motion intensity for each definition used. Q-ratio as defined by Vanmarcke-Lai (Peak Ground Acceleration divided by
root mean square of acceleration) was found not constant but instead it varied significantly for all strong motion definitions.
Similarly, ratio of strong motion intensity over peak ground acceleration squared as defined by Vanmarcke-Lai
holds linear for time durations less than 20-30 seconds for all definitions, afterwards it shows large dispersion. Finally,
Vanmarcke-Lai time duration in seconds appears to increase from near field distance up to a certain medium distance after
which it starts to decrease.
Comparative Analysis of the Energy Dissipation of Steel Buildings with Concentric and Eccentric Braces
Authors: Marquez A. Edelis del V. , Lobo-Q William , Vielma Juan C.
Published: October 2018

A comparative study has been done to analyze the behavior of regular steel building structures of 4, 6, 8 and 10
stories, located in seismic zone 5 and soil type S1. The structures were upgraded with different brace configurations according
to current Venezuelan codes. A total number of 24 numerical models were analyzed considering non-linear static
and incremental dynamic analysis (IDA). The buildings were initially designed as moment resisting frames, and upgraded
with six different bracing configurations: concentric braces in “X” and inverted “V”; eccentric braces inverted "V" with
horizontal links, inverted “Y” and “X” with vertical links. Short length links were used to ensure a shear failure.

The used methodology is based on obtaining the capacity, IDA curves, and bilinear approximations of these curves that
allow the determination of yield and ultimate capacity points, in order to estimate important parameters of seismic response:
overstrength and ductility; and considering these areas under the curves to estimate elastic deformation energy,
energy dissipated by hysteretic damping and equivalent damping.

According to the results, the cases with no brace enhancement showed the lowest lateral strength and lateral stiffness and
high deformation capacity. On the other hand, the concentric bracing cases, resulted with the highest stiffness and strength
and the lowest deformation capacity, therefore they have low ductility and energy dissipation capacity under seismic loading.
Structures with links showed intermediate stiffness and strengths, resulting in the best performance in terms of ductility
and energy dissipation capacity. The present study provides a better understanding of the benefits of eccentrically
braced systems.
Seismic Behavior of Medium and High Strength Concrete Buildings
Authors: Bairán J.M. , Moreno-González R. , Peguero J.
Published: October 2018

Current concrete technology has made higher concrete grades more affordable to mid and high-rise buildings;
hence its use has been increasing in the late years as it allows for smaller cross-sections, reduction of the structure’s
weight, improve durability, among other benefits. However, it is known that brittleness of plain concrete increases with
the strength; therefore, some national codes have limited the concrete’s strength in high seismic zones.

In this paper, the seismic behavior of a 10 storey dual frame-wall building, designed with concrete grades C30, C60 and
C90 is studied in order to assess the advantages and disadvantages of this material and investigate the effects of high concrete
strength on the seismic behavior of buildings. In total, three models were studied. Furthermore, a comparison between
Force-Based-Design (FBD) and Displacement-Based-Design (DBD) methodologies is made. DBD showed advantages
in determining the adequate design ductility and the distribution of forces between frame and wall.

The structures are designed according to Eurocode 8 for seismic design high ductility structures. To assess the seismic
performance of the building, pushover analyses were made according to the Eurocode 8 (N2 method) in order to determine
the performance point.

It is observed that adequate design could accommodate concrete’s reduction of ductility. Needed confinement levels can
objectively be defined for different concrete strength. Some benefits of the overall increase of strength are highlighted in
the paper. The C90 building showed adequate response, although changes on the failure mode were observed.
Probabilistic Seismic Damage Assessment of RC Buildings Based on Nonlinear Dynamic Analysis
Authors: Vargas Yeudy F. , Pujades Lluis G. , Barbat Alex H. , Hurtado Jorge E.
Published: October 2018

The incremental dynamic analysis is a powerful tool for evaluating the seismic vulnerability and risk of buildings.
It allows calculating the global damage of structures for different PGAs and representing this result by means of
damage curves. Such curves are used by many methods to obtain seismic risk scenarios at urban level. Even if the use of
this method in a probabilistic environment requires a relevant computational effort, it should be the reference method for
seismic risk evaluation. In this article we propose to assess the seismic expected damage by using nonlinear dynamic
analysis. We will obtain damage curves by means of the incremental dynamic analysis combined with the damage index
of Park * Ang. The uncertainties related to the mechanical properties of the materials and the seismic action will be considered.
The probabilistic damage curves obtained can be used to calculate not only seismic risk scenarios at urban level,
but also to estimate economic losses.
Influence of P-Delta Effect on Ductility and Vulnerability of SMRF Steel Buildings
Authors: Vielma Pérez Juan Carlos , Cando Loachamín Manuel Antonio
Published: October 2018

Current earthquake-resistant procedures prescribe generic values for the response reductions factors, regardless
of the configurational characteristics of the designed buildings. It is well know that these response reduction factors
values reflect the expected behavior of the structures when they are under strong ground motions, being this seismic
behavior usually evaluated through ductility and over-strength. In this work calculated values of the ductility of special
moment-resisting steel frames with different span lengths and designed according the Ecuadorian Construction Code
are presented. Results show that the buildings’ ductility is strongly influenced by the spans length and they would reach
inadequate values if the second-order effect P-Δ occur, and then indicating that the structures are more vulnerable than structures
not affected by P-Δ effect.
Research on Optimization of Earned Value Management Method in Engineering Budget Management
Authors: Gedi Ji , Yunna Wu , Qing Chang
Published: October 2018

Earned Value Management Method (EVM), widely used in the world, is a project management method of costschedule
integrated control. But the traditional EVM sometimes cannot provide an accurate result. In this paper, a
practical method is given to analyze the project performance, in which the Network Diagram Method and the Critical Path
Method have been introduced into EVM system that can better reflect the practical situation of a project. This improved
method can be referred to assub-level earned value analysis method. This method can correct variance in the duration and
cost forecast of the traditional EVM, and can also provide more information about the cause analysis.
Rapid Development and Application of Prototype Test System of Prefabricated Metro Station Structure Joint
Authors: Huifeng Su , Weining Liu , Xiuren Yang , Chen Wang
Published: October 2018

In the context of the proposed prefabricated metro station named Yuanjiadian Station for Changchun Metro
Line 2 and based on the final purpose of studying the tenon and mortise grouting joint’s mechanical properties, prototype
test system of joint was developed and staged test finished. The test system includes loading system, test and monitoring
system, assembling and grouting system, lifting and installation system and so forth. The system can complete the fourpoint
bending test and four-point shearing test under any axial force of the prototype joint. Afterward, destructive test of
axial force combining with bending moment was carried out under different conditions (including grouting ranges, grouting
materials and tenon lengths). Ultimately, the flexural capacity and flexural rigidity for some specific tenon and mortise
joint was derived and the safe bending moment of the joint was shown, providing guidance for design and construction.
Evaluation of Overall Stability for Garage Foundation Excavation of High Buildings
Authors: Yunshan Han , Han Wu , Yanli Dong , Yuanlong Wang
Published: October 2018

In current projects, many garages were built after the main structure finished. However, the excavation of garage
foundation not only changed the bearing capacity modification by depth, but also makes the soil pressure along the
two sides become different. And thus the stress condition of the main building foundations is changed. The change of
stress condition affects the stability of main structure directly. Based on the stress condition of high buildings foundation
after one side excavation, the change of settlement under the eccentric action was studied. The change of settlement makes
the tilt turning appear and thus makes the overturning resistance moment change. The dynamic principle of stability safety
factors were also investigated in this paper. The effect of settlement affected by the change of stress condition was considered
in the stability analysis of high building. This new method can better and truly evaluate the effect of excavation of
foundation on the stability of overturning resistance than the traditional method considering only the static load-carrying
capability. The operation of the new method is stronger in the project application for its clear mechanism.
ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUHI PENAWARAN KREDIT PADA BANK PERKREDITAN RAKYAT DI SUMATERA (STUDI KASUS TAHUN 2013- 2015)
Authors: Andariyani Ira Meike
Published: October 2018

This study aims to examine the influence of local financial management and regional financial accounting system to the quality of local government financial statements. This research belongs to causative research conducted at regional apparatus organization in Solok City. Data collection is done by survey method through questionnaires distributed to respondents who are in finance or accounting department. The result of the research shows that the management of regional finance has positive correlation but it has no significant effect to the quality of local financial report, while the financial accounting system has significant effect on the quality of local government financial report. This shows that the better the local financial accounting system, the resulting financial statements will also increase.

 

Penelitian ini bertujuan untuk menguji pengaruh pengelolaan keuangan daerah dan sistem akuntansi keuangan daerah terhadap kualitas laporan keuangan pemerintah daerah. Penelitian ini tergolong penelitian kausatif yang dilakukan pada organisasi perangkat daerah di Kota Solok. Pengambilan data dilakukan dengan metode survei melalui penyebaran kuesioner kepada responden yang berada pada bagian keuangan atau akuntansi. Hasil penelitian menunjukan bahwa pengelolaan keuangan daerah memiliki hubungan yang positif tetapi tidak berpengaruh signifikan terhadap kualitas laporan keuangan daerah, sedangkan sistem akuntansi keuangan daerah berpengaruh secara signifikan terhadap kualitas laporan keuangan pemerintah daerah. Hal ini menunjukan bahwa semakin baik sistem akuntansi keuangan daerah maka laporan keuangan yang dihasilkan juga akan semakin meningkat.

 
PROFESSIONAL ATTRIBUTES OF INTERNAL AUDITORS IN RIAU
Authors: Nanda Satria Tri
Published: October 2018

This research aims to identify the factors influencing the audit quality of auditors at Inspektorat Provinsi Riau. The population in this research were auditor, examiner, assistant examiner, and P2UPD (Pengawas Penyelenggara Urusan Pemerintah di Daerah) in charge at the Inspectorate in Riau Province and all Inspectorates in Districts and Cities in Riau Province. A total of 290 set of questionnaire were sent and a number of 184 of questionnaires were processed. Using regression analysis conducted by SPSS, the hypotheses testing analysis results show that experience, responsiveness, professional care, executive involvementt, planning and auditability have significant and positive effect on audit quality. These results indicate that the higher the levels of experience, responsiveness, professional care, executive involvement and auditability of Inspectorate officials, the better the quality of audit performed by the Inspectorate Officials of Riau Province.
PENGARUH LIKUIDITAS, SOLVABILITAS DAN PERPUTARAN MODAL KERJA TERHADAP PROFITABILITAS PADA PERUSAHAAN MANUFAKTUR YANG TERDAFTAR DI BURSA EFEK INDONESIA
Authors: Wahyuliza Suci , Dewita Nola
Published: October 2018

This study aims to determine the effect of liquidity, solvency and working capital turnover on profitability at manufacturing companies listed on the Indonesia Stock Exchange. In this study, the sample used as many as 32 companies. The data used in the form of financial statements listed on the Indonesia Stock Exchange. The data analysis technique used multiple linear regression analysis after passing the classical assumption test consisting of normality test, multicollinearity test, autocorrelation test and heteroscedasticity test. The results prove that liquidity has a significant effect on profitability, solvency has no effect on profitability and turnover of working capital has a significant positive effect on profitability. Of the two influential variables, liquidity has a greater impact than the working capital turnover. Simultaneously liquidity, solvency and turnover of working capital have a significant effect on profitability. The value of R2 Adjusted in this study is 0.159 which means that 15.9% profitability can be influenced by liquidity, solvency and working capital turnover. While the remaining 84.1% influenced by other variables.

 

Penelitian ini bertujuan untuk mengetahui pengaruh likuiditas, solvabilitas dan perputaran modal kerja terhadap profitabilitas pada perusahaan manufaktur yang terdaftar di Bursa Efek Indonesia. Dalam penelitian ini, sampel yang digunakan sebanyak 32 perusahaan. Data yang digunakan berupa laporan keuangan yang terdaftar di Bursa Efek Indonesia. Teknik analisis data menggunakan analisis regresi linier berganda setelah melewati uji asumsi klasik yang terdiri dari uji normalitas, uji multikolinieritas, uji autokorelasi dan uji heteroskedastisitas. Hasil penelitian membuktikan bahwa likuiditas berpengaruh signifikan terhadap profitabilitas, solvabilitas tidak berpengaruh terhadap profitabilitas dan perputaran modal kerja berpengaruh positif signifikan terhadap profitabilitas. Dari kedua variable yang berpengaruh tersebut, likuiditas mempunyai pengaruh yang lebih besar dibandingkan dengan perputaran modal kerja. Secara simultan likuiditas, solvabilitas dan perputaran modal kerja berpengaruh signifikan terhadap profitabilitas. Nilai R2 Adjusted dalam penelitian ini sebesar 0.159 yang berarti bahwa 15.9%  profitabilitas dapat dipengaruhi oleh likuiditas, solvabilitas dan perputaran modal kerja. Sedangkan sisanya 84.1% dipengaruhi oleh variabel-variabel lain.
PUBLIC REIMBURSEMENT OF PRESCRIPTION DRUG USED FOR OFF-LABEL INDICATIONS IN ONTARIO
Authors: B Rawson Nigel S , Chhabra Arpit
Published: October 2018

Background

A Canadian Agency for Drugs and Technologies in Health therapeutic review concluded that bevacizumab and ranibizumab have similar efficacy and safety in treating retinal conditions and recommended bevacizumab be used as preferred initial therapy based on a cost-saving perspective. Such use would be off-label because bevacizumab’s Product Monograph (PM) has a serious safety warning that the drug is not formulated or authorized for intravitreal use.

Objective

To evaluate whether the Ontario Public Drug Programs (OPDP) reimbursement is provided only for off- label use for serious conditions or when the drug’s PM contains a serious safety warning.

Methods

Comparisons were made between the OPDP reimbursement criteria for non-palliative drugs from its frequently requested Exceptional Access Program (EAP) list and for non-palliative injectable drugs from its Limited Use (LU) list and approved indications and serious safety warnings in the drugs’ PMs.

Results

Of 125 unique frequently-requested non-palliative EAP drugs, 12 included off-label use for serious conditions for which no alternative treatment exists. Eight of the 12 had serious safety warnings, but only one had a serious safety warning directly related to the OPDP-reimbursed off-label use. Of 29 non-palliative injectable LU drugs, one had off-label LU criteria allowing reimbursement for an unapproved indication and a serious safety warning unrelated to the reimbursable indication.

Conclusion

Presently, OPDP only reimburse drugs for off-label use for the treatment of serious conditions for which no alternative treatment exists. OPDP should not diverge from this approach by allowing cost-savings to trump appropriate drug use.
CAPT / ACTP Annual Meeting 2018
Authors: Bryant Scott
Published: October 2018

Abstracts from the CAPT / ACTP Annual Meeting 2018
On the advantage of normal heights
Authors: Popadyev V.V.
Published: October 2018

The author analyzes the arguments in the report by Robert Kingdon, Petr Vanicek and Marcelo Santos “The shape of the quasigeoid” (IX Hotin-Marussi Symposium on Theoretical Geodesy, Italy, Rome, June 18 June 22, 2018), which presents the criticisms for the basic concepts of Molodensky’s theory, the normal height and height anomaly of the point on the earth’s surface, plotted on the reference ellipsoid surface and forming the surface of a quasigeoid. The main advantages of the system of normal heights, closely related to the theory of determining the external gravitational field and the Earth’s surface, are presented. Despite the fact that the main advantage of Molodensky’s theory is the rigorous determining the anomalous potential on the Earth’s surface, the use of the system of normal heights can be shown and proved separately. To do this, a simple example is given, where the change of marks along the floor of a strictly horizontal tunnel in the mountain massif is a criterion for the convenience of the system. In this example, the orthometric heights show a change of 3 cm per 1.5 km, which will require corrections to the measured elevations due the transition to a system of orthometric heights. The knowledge of the inner structure of the rock mass is also necessary. It should be noted that the normal heights are constant along the tunnel and behave as dynamic ones and there is no need to introduce corrections. Neither the ellipsoid nor the quasi-geoid is a reference for normal heights, because so far the heights are referenced to initial tide gauge. The points of the earth’s surface are assigned a height value; this is similar to the ideas of prof. L. V. Ogorodova about the excessive emphasis on the concept of quasigeoid. A more general term is the height anomaly that exists both for points on the Earth’s surface and at a distance from it and decreases together with an attenuation of the anomalous field.
MONITORING OF ELECTRICAL SYSTEM USING INTERNET OF THINGS WITH SMART CURRENT ELECTRIC SENSORS
Authors: Ibnu Hajar Muhammad Hafizd , Dani Akhmad Wahyu , Miharno Satriyo
Published: October 2018

Electricity is one of the most important human needs. In the presence of electricity it can facilitate human work. But it should be noted that too large and uncontrolled electricity use will be wasteful and get high costs. The problem is that electricity is not monitored accurately, easily and efficiently. This study aims to design an electric current monitoring device with an IoT system. IoT is a concept with the ability to transfer data by network, no need humans to humans or humans to PCs. In this concept, the SCT 013-000 electric current sensor is connected to the load, it will be show electric current value in the LCD, if the electric current which is determined exceeds the capacity, Wemos D1 including Wifi ESP 8266 will be sending a notification to the telegram. The system has been implemented with ironing load for 3.29%, the dispenser load is 0.20% and Magicom's get load for 1.07%. The delay time also has been implemented in the relay for 1.50 second when relay is on and 0.78 second when relay is off. When the notification send to the telegram also have a delay for 6.2 second. So, monitoring of electrical system using internet of things with smart current electric sensors has been done.
Caminhoneiro de transporte rodoviário de cargas: busca de tratamentos odontológicos
Authors: Santos Nellis Oliveira , Kawamoto Jr Luiz Teruo , Cardoso Hewely , Carvajal Jr. Claudio José , Bonini Luci Mendes , Kawamoto Waltraudi Orchulhak
Published: October 2018

O objetivo desta pesquisa foi explorar hábitos dos caminhoneiros na busca por tratamentos odontológicos. O método da pesquisa utilizado foi quantitativo, exploratório-descritivo e de corte transversal, com 270 sujeitos de pesquisa. O estudo incluiu caminhoneiros com idade de vinte e um a sessenta anos que atuam no ramo de transporte rodoviário de cargas e trafegam na Rodovia Presidente Dutra. Apesar de não estatisticamente diferente, foi detectada tendência de quanto maior o grau de instrução, maior a renda; e quanto maior o grau de instrução, são buscadas melhores formas de tratamentos odontológicos; o fator renda não teve influência forma busca de tratamento odontológico. Como sugestão de futura pesquisa, fazer uma pesquisa mais ampla, de forma a possibilitar melhores análises estatísticas.
Analysis of genetic parameters and genetic trends for early growth traits in Iranian Afshari sheep
Authors: Latifi Meysam , Mohammadi Ali
Published: October 2018

The purpose of the present study was estimation of genetic parameters and
genetic trends of early growth traits using Bayesian approach by Gibbs3f90
software in Iranian Afshari sheep. The data set [birth weight (BW), weaning
weight (WW) and pre-weaning daily weight gain (PWDG)] were collected during
the period 1999 to 2010 from Agriculture Jahad of Zanjan province, Iran. The
fitted fixed effects were herd-year-season as interactions, sex (male,
female), birth type (single, multiple) and age of dam. Based on Derivative
Information Criteria (DIC), for studied traits the most appropriate model
was determined. Therefore, based on the most appropriate fitted model, the
direct additive heritabilities estimate for BW, WW and PWDG were 0.32?0.02,
0.05?0.01 and 0.24?0.02, respectively. The estimates of maternal
heritabilities were 0.17?0.04, 0.07?0.02 and 0.12?0.05 and total
heritabilities 0.11?0.05, 0.08?0.02 and 0.08?0.03 for BW, WW and PWDG,
respectively. Direct genetic trends were positive for all traits but only
significant for BW 0.75?0.31 g/year (P <0.05). Also, maternal genetic trends
were for all traits negative and was significant for BW -0.63?0.27 g/year (P
<0.05). The moderate estimates of heritabilities for early growth traits
indicate that in Afshari sheep faster genetic improvement through selection
is possible for these traits. Furthermore, the results genetic trends in
this current study indicated that genetic improvement through selection is
suitable only for BW in Afshari sheep.
Regression models for estimating chick hatchling weight from some egg geometry traits
Authors: Mincheva Nadya , Lalev Mitko , Oblakova Magdalena , Hristakieva Pavlina
Published: October 2018

The prediction of chicks? weight before hatching is an important element of
selection, aimed at improving the uniformity rate and productivity of birds.
With this regards, our goal was to develop and evaluate optimum models for
similar prediction in two White Plymouth Rock chickens lines - line L and
line K on the basis of the incubation egg weight and egg geometry
characteristics - egg maximum breadth (B), egg length (L), geometric mean
diameter (Dg), egg volume (V), egg surface area (S). A total of 280 eggs
(140 from each line) laid by 40-weekold hens were randomly selected. Mean
arithmetic values, standard deviations and coefficients of variation of
studied parameters were determined for each line. Correlation coefficients
between the weight of hatchlings and predictors were the highest for egg
weight, geometric mean diameter, volume and surface area of eggs
(r=0.731-0.779 for line L; r=0.802-0.819 for line ?). Nine linear regression
models were developed and their accuracy evaluated. The regression equations
of hatchlings? weight vs egg length had the lowest coefficient of
determination (0.175 for line K and 0.291 for line L), but when egg length
and breadth entered the model together, its value increased significantly up
to 0.541 and 0.665 for lines L and K, respectively. The weight of day-old
chicks from line L could be predicted with higher accuracy with a model
involving egg surface area apart egg weight (ChW=0.513EW+0.282S - 10.345;
R2=0.620). In line ? a more accurate prognosis was attained by adding egg
breadth as an additional predictor to the weight in the model
(ChW=0.587EW+0.566? - 19.853; R2=0.692). The study demonstrated that
multiple linear regression models were more precise that single linear
models.
INCUBADORA DE EMPRESAS Y PLANES DE NEGOCIOS LA CULTURA DEL EMPRENDIMIENTO
Authors: Parada Carvajal Álvaro Parada Carvajal
Published: October 2018

El modelo de desarrollo empresarial, impulsado en muchos Países con el nombre deINCUBADORAS, establece el reto de aplicar el modelo pedagógico de APRENDER HACIENDO,por lo que la mejor manera de enseñar la creación y consolidación de empresas es haciendoempresas.Con base en esta definición se deduce que el liderazgo que debe asumir la universidad, en laconducción de la incubadora, debe expresarse en aportar el conocimiento de sus investigadores,directivos, académicos y estudiantes, para facilitar la articulación de sus propósitos empresarialescon los sectores económicos vinculados al desarrollo económico de la región y el país, con miras encrear las condiciones demandadas para la creación y consolidación de empresas.El estudiante de Administración, es ubicado de acuerdo a nuestro modelo universitario que no seconsidera como algo estático y acabado, ya que emprende planes de mejoramiento continuo ysustenta su labor académica en el debate permanente de ideas que jalonan el progreso de lasociedad
LOCALIZACION Y ANALISIS DE LOS SECTORES ECONOMICOS DE CUCUTA SEGUN LAS EMPRESAS AFILIADAS A FENALCO COMO HERRAMIENTA PARA LA REALIZACION DE PROYECTOS ECONOMICOS
Authors: Ordoñez Santos Mary Luz
Published: October 2018

La investigación “Localización y Análisis de los sectores económicos de Cúcuta según las empresas afiliadasa FENALCO como herramienta para la realización de proyectos de desarrollo económico”, se realizó con elapoyo de la Federación Nacional de Comerciantes con el propósito de lograr los siguientes objetivos:Identificar las empresas existentes en la ciudad de Cúcuta según las bases de datos de FENALCO y laCámara de Comercio de Cúcuta; clasificar las empresas de FENALCO Cúcuta por sectores y subsectoreseconómicos de acuerdo a la Clasificación Internacional Uniforme CIIU; localizar las empresas de Cúcutaafiliadas a FENALCO de acuerdo a los sectores económicos por las comunas definidas en el POT de laciudad; especificar el tipo de sociedad de los negocios registrados en la base de datos de FENALCO Cúcutaapoyándonos en la base de datos de la Cámara de Comercio de Cúcuta y Pamplona: y por ultimo efectuar unestudio de campo para determinar la opinión y expectativas que tienen los comerciantes de Cúcuta acerca deFENALCO.En consecuencia esta publicación será un aporte que permita aentidades públicas y privadas, empresarios, emprendedores,investigadores y comunidad educativa; entre otros, tomarla comoreferencia para la realización de estudios, investigaciones, proyectos;que contribuyan al desarrollo social y económico de la ciudad.
COMPOSITION OF THE JOB-SEEKER STOCK IN LABOUR MARKET MATCHING :A STOCHASTIC FRONTIER APPROACH
Authors: Mari Hynninen Sanna
Published: October 2018

This paper investigates the technical efficiency of labour market matching taking a stochastic frontierapproach. The data set consists of monthly data from 145 Local Labour Offices (LLOs) in Finland over theperiod 1995/01-2004/09. The true fixed-effects model is utilised in order to separate cross-sectionalheterogeneity from inefficiency. According to the results, there are notable differences in matching efficiencybetween regions, and these differences contribute significantly to the number of filled vacancies. If all regionswere as efficient as the most efficient one, the number of total matches per month would increase by over 10%. If inefficiency had no role in the matching function, the number of matches would increase by almost 24 %.The weight of the composition of the job-seeker stock and other environmental variables in the determinationof matching inefficiency is on average 61 %. In particular, job seekers out of the labour force and highlyeducated job seekers improve technical efficiency in the matching function
LOS SUJETOS QUE HABITAN LAS FRONTERAS
Authors: Felice María Fernanda
Published: October 2018

INTRODUCCIÓN: Se intenta abordar la realidad de muchos niños/as que pese a no presentar una patología o discapacidad requieren de un diagnóstico o certificado, que les asegure su permanencia en la escuela, en un proyecto de integración o inclusión escolar y una serie de prestaciones de la salud. MÉTODOS: Se ofrece una revisión histórica acerca de la construcción social en torno a la “diferencia y la normalidad”, a fin de comprender que las prácticas médicas y educativas actuales no distan demasiado de la antigüedad. RESULTADOS: Sólo se ha conseguido sustituir algunos nombres por otros pero los arquetipos permanecen intactos y la separación continúa siendo la respuesta más frecuente para aquellos sujetos que habitan las fronteras, que se encuentran en situación de exclusión social. ANÁLISIS Y DISCUSIÓN: Se cuestiona el uso de los “DSM”, que promueve la “patologización y medicalización de las infancias”. CONCLUSIONES: se desconoce los riesgos del etiquetamiento temprano y sus efectos en el devenir de los niños/as.
TECNOLOGÍA DE LA COMUNICACIÓN Y SISTEMAS DE COMUNICACIÓN EN EL LENGUAJE. REVISIÓN SISTEMÁTICA DESDE LA FONOAUDIOLOGÍA
Authors: Pérez Ginna , Martínez Aura , Peñaloza Zayda , Ríos Niyireth , Ortega Yury , Zambrano Laura , Martínez Jennyfer , Sinuco Yulieth
Published: October 2018

INTRODUCCIÓN: El objetivo de este estudio, es analizar la evidencia científica disponible en la intervención de personas en situación de discapacidad y la comunicación aumentativa y alternativa, a fin de generar avances significativos en el área de la Fonoaudiología. MÉTODOS: revisión sistemática de tipo descriptivo en donde se realiza una búsqueda en diferentes bases de datos en una línea de tiempo de 10 años siendo en estudios con seres humanos en situación de discapacidad. RESULTADOS: Esta revisión permitió evidenciar los diferentes recursos disponibles en los niveles Fonético Fonológico, Semántico, Morfosintáctico y utilización de tecnología de la comunicación en el lenguaje para personas en situación de discapacidad.