bluuebunny/crossref_metadata_2025 huggingface dataset:
Measured and Predicted Operating Characteristics of a Tilting-Pad Journal Bearing with Jacking-Oil Device at Hydrostatic, Hybrid, and Hydrodynamic Operation
Authors: Hagemann Thomas , Pfeiffer Peter , Schwarze Hubert
Published: September 2018

Jacking-oil pockets are applied in many journals and thrust bearing applications in order to provide a hydrostatic oil film force that ensures a wear free run-up following a successful lift-off procedure. However, all components of the jacking-oil system have to be carefully designed in order to limit costs and prevent significant disturbance of hydrodynamic operation after deactivation of lift-oil. Experimental data and predictions for a four-pad tilting-pad journal bearing in load between pivot configuration are presented. Dynamic processes of the lift-off procedure as well as characteristic parameters of stationary conditions are studied. Moreover, hydrodynamic operation and hybrid lubrication providing a combined hydrodynamic and hydrostatic pressure distribution are investigated for sliding speeds up to 20 m/s. Analyzes of lift-off procedure prove that characteristic parameters such as lift-off pressures and vertical lift displacements are considerably influenced by manufacturing tolerances and misalignments. The comparison of hydrodynamic and hybrid lubrication provides a significant increase of load carrying capacity by additional jacking-oil supply at the maximum journal speed. In summary, results of measurements and predictions correlate well for all three investigated lubrication conditions.
Bearings Downsizing by Strength Enhancement and Service Life Extension
Authors: Amanov Auezhan , Darisuren Shirmendagva , Pyun Young-Sik
Published: September 2018

Slim bearings are used widely in aircrafts, robots, wind turbines, and industrial machineries, where their size and weight are very important for the performance of a system. The common materials of slim bearings for robots and industrial machineries are based on SAE52110 bearing steel, and special heat treatment and a super polishing process are used and adapted to improve the rolling contact fatigue (RCF) strength of bearings. The improvement in RCF strength, depending on contact stress, surface hardness, and the friction behavior before and after ultrasonic nanocrystalline surface modification (UNSM) treatment was validated. Simple analysis shows that these improvements can reduce the size and weight of slim bearings down to about 3.40–21.25% and 14.3–26.05%, respectively. Hence, this UNSM technology is an opportunity to implement cost-saving and energy consuming super-polishing, a heat treatment process, and to reduce the size and weight of slim bearings.
Mechanical Properties and In Situ Deformation Imaging of Microlattices Manufactured by Laser Based Powder Bed Fusion
Authors: Du Plessis Anton , Kouprianoff Dean-Paul , Yadroitsava Ina , Yadroitsev Igor
Published: September 2018

This paper reports on the production and mechanical properties of Ti6Al4V microlattice structures with strut thickness nearing the single-track width of the laser-based powder bed fusion (LPBF) system used. Besides providing new information on the mechanical properties and manufacturability of such thin-strut lattices, this paper also reports on the in situ deformation imaging of microlattice structures with six unit cells in every direction. LPBF lattices are of interest for medical implants due to the possibility of creating structures with an elastic modulus close to that of the bones and small pore sizes that allow effective osseointegration. In this work, four different cubes were produced using laser powder bed fusion and subsequently analyzed using microCT, compression testing, and one selected lattice was subjected to in situ microCT imaging during compression. The in situ imaging was performed at four steps during yielding. The results indicate that mechanical performance (elastic modulus and strength) correlate well with actual density and that this performance is remarkably good despite the high roughness and irregularity of the struts at this scale. In situ yielding is visually illustrated.
The Effect of Crystal Defects on 3D High-Resolution Diffraction Peaks: A FFT-Based Method
Authors: Eloh Komlavi Senyo , Jacques Alain , Ribarik Gabor , Berbenni Stéphane
Published: September 2018

Forward modeling of diffraction peaks is a potential way to compare the results of theoretical mechanical simulations and experimental X-ray diffraction (XRD) data recorded during in situ experiments. As the input data are the strain or displacement field within a representative volume of the material containing dislocations, a computer-aided efficient and accurate method to generate these fields is necessary. With this aim, a current and promising numerical method is based on the use of the fast Fourier transform (FFT)-based method. However, classic FFT-based methods present some numerical artifacts due to the Gibbs phenomenon or “aliasing” and to “voxelization” effects. Here, we propose several improvements: first, a consistent discrete Green operator to remove “aliasing” effects; and second, a method to minimize the voxelization artifacts generated by dislocation loops inclined with respect to the computational grid. Then, we show the effect of these improvements on theoretical diffraction peaks.
Ge2Sb2Te5 p-Type Thin-Film Transistors on Flexible Plastic Foil
Authors: Daus Alwin , Han Songyi , Knobelspies Stefan , Cantarella Giuseppe , Tröster Gerhard
Published: September 2018

In this work, we show the performance improvement of p-type thin-film transistors (TFTs) with Ge 2 Sb 2 Te 5 (GST) semiconductor layers on flexible polyimide substrates, achieved by downscaling of the GST thickness. Prior works on GST TFTs have typically shown poor current modulation capabilities with ON/OFF ratios ≤20 and non-saturating output characteristics. By reducing the GST thickness to 5 nm, we achieve ON/OFF ratios up to ≈300 and a channel pinch-off leading to drain current saturation. We compare the GST TFTs in their amorphous (as deposited) state and in their crystalline (annealed at 200 °C) state. The highest effective field-effect mobility of 6.7 cm 2 /Vs is achieved for 10-nm-thick crystalline GST TFTs, which have an ON/OFF ratio of ≈16. The highest effective field-effect mobility in amorphous GST TFTs is 0.04 cm 2 /Vs, which is obtained in devices with a GST thickness of 5 nm. The devices remain fully operational upon bending to a radius of 6 mm. Furthermore, we find that the TFTs with amorphous channels are more sensitive to bias stress than the ones with crystallized channels. These results show that GST semiconductors are compatible with flexible electronics technology, where high-performance p-type TFTs are strongly needed for the realization of hybrid complementary metal-oxide-semiconductor (CMOS) technology in conjunction with popular n-type oxide semiconductor materials.
Independently Tunable Fano Resonances Based on the Coupled Hetero-Cavities in a Plasmonic MIM System
Authors: Wang Qiong , Ouyang Zhengbiao , Lin Mi , Liu Qiang
Published: September 2018

In this paper, based on coupled hetero-cavities, multiple Fano resonances are produced and tuned in a plasmonic metal-insulator-metal (MIM) system. The structure comprises a rectangular cavity, a side-coupled waveguide, and an upper-coupled circular cavity with a metal-strip core, used to modulate Fano resonances. Three Fano resonances can be realized, which originate from interference of the cavity modes between the rectangular cavity and the metal-strip-core circular cavity. Due to the different cavity-cavity coupling mechanisms, the three Fano resonances can be divided into two groups, and each group of Fano resonances can be well tuned independently by changing the different cavity parameters, which can allow great flexibility to control multiple Fano resonances in practice. Furthermore, through carefully adjusting the direction angle of the metal-strip core in the circular cavity, the position and lineshape of the Fano resonances can be easily tuned. Notably, reversal asymmetry takes place for one of the Fano resonances. The influence of the direction angle on the figure of merit (FOM) value is also investigated. A maximum FOM of 3436 is obtained. The proposed structure has high transmission, sharp Fano lineshape, and high sensitivity to change in the background refractive index. This research provides effective guidance to tune multiple Fano resonances, which has important applications in nanosensors, filters, modulators, and other related plasmonic devices.
Terpenoids from Marine Soft Coral of the Genus Lemnalia: Chemistry and Biological Activities
Authors: Wu Qihao , Sun Jiadong , Chen Jianwei , Zhang Huawei , Guo Yue-Wei , Wang Hong
Published: September 2018

Lemnalia is one of the most widely-distributed marine soft coral in tropical oceans and is known to produce novel terpenoids with a broad spectrum of biological activities. This review provides the first comprehensive overview of terpenoids produced by soft coral Lemnalia since their first discovery in 1974.
Fucoxanthin Inhibits Myofibroblast Differentiation and Extracellular Matrix Production in Nasal Polyp-Derived Fibroblasts via Modulation of Smad-Dependent and Smad-Independent Signaling Pathways
Authors: Jung Hyun , Lee Dae-Sung , Park Seong Kook , Choi Jung Sik , Jung Won-Kyo , Park Won Sun , Choi Il-Whan
Published: September 2018

Nasal polyps (NPs) are a multifactorial disorder associated with a chronic inflammatory state of the nasal mucosa. Fucoxanthin (Fx) is a characteristic orange carotenoid obtained from brown algae and has diverse immunological properties. The present study investigated whether Fx inhibits fibrosis-related effects in nasal polyp-derived fibroblasts (NPDFs) and elucidated the molecular signaling pathways involved. The production of collagen type I (Col-1) was investigated in NP tissue via immunohistochemistry and western blot analysis. NPDFs were treated with transforming growth factor (TGF)-β1 (1 ng/mL) in the presence or absence of Fx (5–30 µM). The levels of α-smooth muscle actin (α-SMA), Col-1, and phosphorylated (p)-Smad 2/3, signal protein-1 (SP-1), MAPKs (mitogen-activated protein kinases), and Akt were measured by western blot analysis. The expression of Col-1 was detected in NP tissues. TGF-β1 stimulated the production of α-SMA and Col-1, and stimulated the contraction of collagen gel. However, pretreatment with Fx attenuated these effects. Furthermore, these inhibitory effects were mediated through modulation of both Smad 2/3 and Akt/SP-1 signaling pathways in TGF-β1-induced NPDFs. The results from the present study suggest that Fx may be a novel anti-fibrotic agent for the treatment of NP formation.
Utilization of DES-Lignin as a Bio-Based Hydrophilicity Promoter in the Fabrication of Antioxidant Polyethersulfone Membranes
Authors: Esmaeili Mohammadamin , Anugwom Ikenna , Mänttäri Mika , Kallioinen Mari
Published: September 2018

Enhancement of membrane permeability at no detriment of its other performances, e.g., selectivity, is a goal-directed objective in membrane fabrication. A novel antioxidant DES-lignin (lignin extracted from birch wood by using a deep eutectic solvent) polyethersulfone (PES) membrane, containing 0–1 wt % DES-lignin, was fabricated with the phase inversion technique. The performance and morphology of the fabricated membranes were characterized by a pure water flux, polyethylene glycol (PEG) retention, Fourier transform infrared spectroscopy, scanning electron microscopy, and contact angle measurements. Membranes with less negative charge and better hydrophilicity were obtained when the DES-lignin content in the polymer solution was increased. With the highest dosage, the incorporation of DES-lignin in the membrane matrix improved the membrane permeability by 29.4% compared to a pure PES membrane. Moreover, no leakage of DES-lignin from the membrane structure was observed, indicating good compatibility of DES-lignin with the PES structure. It was also found that the improvement of both rejection and pure water flux could be achieved by using a small dosage of DES-lignin (0.25 wt %) in membrane fabrication. The membranes incorporated with DES-lignin showed higher DPPH (2,2-diphenyl-1-picrylhydrazyl) and ABTS (2,2-Azino-bis (3-ethylbenzothiazoline-6-sulfonic acid)) scavenging activity compared to the pure membrane, where 2.6 and 1.1 times higher DPPH and ABTS scavenging activity was observed with the highest DES-lignin content (1 wt %). Thus, the results of this study demonstrate well the feasibility of utilizing DES-lignin as an antioxidant bio-based hydrophilicity promoter in the fabrication of ultrafiltration membranes.
Influence of σ Phase on the Allotropic Transformation of the Matrix in Co-Re-Cr-Based Alloys with Ni Addition
Authors: Dörries Kai , Mukherji Debashis , Rösler Joachim , Esleben Katharina , Gorr Bronislava , Christ Hans-Juergen
Published: September 2018

Co-Re-Cr alloys are being developed for high-temperature application in gas turbines. In these alloys, the Cr2Re3-based σ phase is stable when the Cr content is higher than 20 atomic %. The addition of Ni is being studied to partially substitute Cr, which aims to suppress σ formation without sacrificing the benefit of Cr in the oxidation resistance of the alloy. The microstructure of the alloys with varying Cr (18–23%) and Ni (8–25%) was investigated by electron microscopy in the present study, primarily to look into the stability of the σ phase and its influence on the Co matrix phase transformation. The σ phase is mainly found in two morphologies in these alloys, where at high temperature only blocky σ phase is present at grain boundaries but cellular σ is formed through a discontinuous precipitation within the grains at lower heat treatment temperatures. The presence of fine cellular σ phase influences the alloy hardness. Moreover, the σ precipitation, which depletes the matrix in Re, also influences the allotropic transformation of the Co matrix.
Simultaneously Enhanced Strength, Toughness and Ductility of Cast 40Cr Steels Strengthened by Trace Biphase TiCx-TiB2 Nanoparticles
Authors: Li Chuan-Lu , Qiu Feng , Chang Fang , Zhao Xu-Min , Geng Run , Yang Hong-Yu , Zhao Qing-Long , Jiang Qi-Chuan
Published: September 2018

Simultaneously improving the strength, toughness, and ductility of cast steels has always been a difficult problem for researchers. Biphase TiCx-TiB2 nanoparticle-reinforced cast steels are prepared by adding in situ nanosized biphase TiCx-TiB2/Al master alloy during the casting process. The experimental results show that a series of significant changes take place in the microstructure of the steel: the ferrite-pearlite structure of the as-cast steels and the bainite structure of the steels after heat treatment are refined, the grain size is reduced, and the content of nanoparticles is increased. Promotion of nucleation and inhibition of dendrite growth by biphase TiCx-TiB2 nanoparticles leads to a refinement of the microstructure. The fine microstructure with evenly dispersed nanoparticles offers better properties [yield strength (1246 MPa), tensile strength (1469 MPa), fracture strain (9.4%), impact toughness (20.3 J/cm2) and hardness (41 HRC)] for the steel with 0.018 wt.% biphase TiCx-TiB2 nanoparticles, which are increased by 15.4%, 31.2%, 4.4%, 11.5%, and 7.9% compared with the 40Cr steels. The higher content of nanoparticles provides higher strengths and hardness of the steel but are detrimental to ductility. The improved properties may be attributed to fine grain strengthening and the pinning effect of nanosized carbide on dislocations and grain boundaries. Through this work, it is known that the method of adding trace (0.018 wt.%) biphase TiCx-TiB2 nanoparticles during casting process can simultaneously improve the strength, toughness, as well as ductility of the cast steel.
Utilization of 2:1 Internal Resonance in Microsystems
Authors: Noori Navid , Sarrafan Atabak , Golnaraghi Farid , Bahreyni Behraad
Published: September 2018

In this paper, the nonlinear mode coupling at 2:1 internal resonance has been studied both analytically and experimentally. A modified micro T-beam structure is proposed, and the equations of motion are developed using Lagrange’s energy method. A two-variable expansion perturbation method is used to describe the nonlinear behavior of the system. It is shown that in a microresonator with 2:1 internal resonance, the low-frequency mode is autoparametrically excited after the excitation amplitude reaches a certain threshold. The effect of damping on the performance of the system is also investigated.
Activity Monitoring with a Wrist-Worn, Accelerometer-Based Device
Authors: Lin Wen-Yen , Verma Vijay Kumar , Lee Ming-Yih , Lai Chao-Sung
Published: September 2018

This study condenses huge amount of raw data measured from a MEMS accelerometer-based, wrist-worn device on different levels of physical activities (PAs) for subjects wearing the device 24 h a day continuously. In this study, we have employed the device to build up assessment models for quantifying activities, to develop an algorithm for sleep duration detection and to assess the regularity of activity of daily living (ADL) quantitatively. A new parameter, the activity index (AI), has been proposed to represent the quantity of activities and can be used to categorize different PAs into 5 levels, namely, rest/sleep, sedentary, light, moderate, and vigorous activity states. Another new parameter, the regularity index (RI), was calculated to represent the degree of regularity for ADL. The methods proposed in this study have been used to monitor a subject’s daily PA status and to access sleep quality, along with the quantitative assessment of the regularity of activity of daily living (ADL) with the 24-h continuously recorded data over several months to develop activity-based evaluation models for different medical-care applications. This work provides simple models for activity monitoring based on the accelerometer-based, wrist-worn device without trying to identify the details of types of activity and that are suitable for further applications combined with cloud computing services.
Nature and Evolution of Paleoproterozoic Sn and Rare Metal Albitites from Central Brazil: Constraints Based on Textural, Geochemical, Ar-Ar, and Oxygen Isotopes
Authors: Sirqueira Ana Rita F. , Moura Márcia A. , Botelho Nilson F. , Kyser T. Kurt
Published: September 2018

Economic and subeconomic concentrations of Sn, In, rare earth elements (REE), Ta, and Nb are known in Central Brazil, in the Goias Tin Province. The Sn-P enriched albitites studied in this paper occur in sharp contact with peraluminous granites of the Aurumina Suite (2.0–2.17 Ga) and schists of the Archean to Paleoproterozoic Ticunzal Formation, as dikes or lenses from late-stage magma of the peraluminous magmatism, probably in granite cupolas. Geological, petrological, and isotopic studies were conducted. The albitites consist of albite, quartz, cassiterite, apatite, K-feldspar, and muscovite, and have magmatic texture, such as alignment of albite laths, and snowball texture in quartz, apatite, and cassiterite. They are enriched in Na2O, P2O5, Sn, Ta, and Nb (Ta > Nb), and depleted in CaO, K2O, TiO2, MgO, Sr, Ba, Th, and REE. 40Ar/39Ar in muscovite gave a plateau age of 1996.55 ± 13 Ma, interpreted as approaching the crystallization age. Oxygen isotope data in albite-cassiterite pairs resulted in an equilibrium temperature of 653–1016 °C and isotopic fluid composition of 8.66–9.72‰. They were formed by crystallization of a highly evolved and sodic granitic magma. This study has implications for Central Brazil’s economic potential and offers better understanding of tin behavior in rare, evolved peraluminous granitic magmas.
The Effects of Berberine on the Gut Microbiota in Apc min/+ Mice Fed with a High Fat Diet
Authors: Wang Huan , Guan Lingnan , Li Jing , Lai Maode , Wen Xiaodong
Published: September 2018

Background: Berberine (BBR) has been extensively reported to inhibit colorectal cancer (CRC) development, though its bioavailability is poor. Nowadays, an increasing number of studies have shown that BBR significantly accumulates in the intestines and could regulate gut microbiota in obesity. The purpose of this study was to further explore the effects of BBR on gut microbiota in Apc min/+ mice receiving a high fat diet (HFD). Methods: Apc min/+ mice received either HFD alone or HFD and BBR for 12 weeks. The intestinal tissues were collected to evaluate the efficiency of BBR on neoplasm development by hematoxylin and eosin staining. Meanwhile, immunohistochemistry was conducted to investigate the effects of BBR on cyclin D1 and β-catenin in colon tissues. Fecal samples were subjected to 16S rRNA sequencing. Results: BBR significantly reduced intestinal tumor development and altered the structure of gut microbiota in Apc min/+ mice fed with an HFD. At the phylum level, it was able to significantly inhibit the increase in Verrucomicrobia. At the genus level, it was able to suppress Akkermansia and elevate some short chain fat acid (SCFA)-producing bacteria. Conclusions: BBR significantly alleviated the development of CRC in Apc min/+ mice fed with HFD and restored the enteric microbiome community.
Response of Cisplatin Resistant Skov-3 Cells to [Pt(O,O′-Acac)(γ-Acac)(DMS)] Treatment Revealed by a Metabolomic 1H-NMR Study
Authors: De Castro Federica , Benedetti Michele , Antonaci Giovanna , Del Coco Laura , De Pascali Sandra Angelica , Muscella Antonella , Marsigliante Santo , Fanizzi Francesco Paolo
Published: September 2018

The novel [Pt(O,O′-acac)(γ-acac)(DMS)], Ptac2S, Pt(II) complex has recently gained increasing attention as a potential anticancer agent for its pharmacological activity shown in different tumor cell lines, studied both in vitro and in vivo. The mechanism of action of Ptac2S, operating on non-genomic targets, is known to be very different from that of cis-[PtCl2(NH3)2], cisplatin, targeting nucleic acids. In this work, we evaluated the cytotoxicity of Ptac2S on the cisplatin resistant Epithelial Ovarian Carcinoma (EOC), SKOV-3 cells, by the MTT assay. A 1H-NMR metabolomic approach coupled with multivariate statistical analysis was used for the first time for Ptac2S to figure out the biological mechanisms of action of the complex. The metabolic variations of intracellular metabolites and the composition of the corresponding extracellular culture media were compared to those of cisplatin (cells were treated at the IC50 doses of both drugs). The reported comparative metabolomic analysis revealed a very different metabolic profile between Ptac2S and cisplatin treated samples, thus confirming the different mechanism of action of Ptac2S also in the Epithelial Ovarian Carcinoma (EOC), SKOV-3 cells line. In particular, higher levels of pyruvate were observed in Ptac2S treated, with respect to cisplatin treated, cells (in both aqueous and culture media). In addition, a very different lipid expression resulted after the exposure to the two drugs (Ptac2S and cisplatin). These results suggest a possible explanation for the Ptac2S ability to circumvent cisplatin resistance in SKOV-3 cells.
Phenethyl Isothiocyanate Inhibits In Vivo Growth of Xenograft Tumors of Human Glioblastoma Cells
Authors: Chou Yu-Cheng , Chang Meng-Ya , Lee Hsu-Tung , Shen Chiung-Chyi , Harnod Tomor , Liang Yea-Jiuan , Wu Rick Sai-Chuen , Lai Kuang-Chi , Hsu Fei-Ting , Chung Jing-Gung
Published: September 2018

Phenethyl isothiocyanate (PEITC) from cruciferous vegetables can inhibit the growth of various human cancer cells. In previous studies, we determined that PEITC inhibited the in vitro growth of human glioblastoma GBM 8401 cells by inducing apoptosis, inhibiting migration and invasion, and altering gene expression. Nevertheless, there are no further in vivo reports disclosing whether PEITC can suppress the growth of glioblastoma. Therefore, in this study we investigate the anti-tumor effects of PEITC in a xenograft model of glioblastoma in nude mice. Thirty nude mice were inoculated subcutaneously with GBM 8401 cells. Mice with one palpable tumor were divided randomly into three groups: control, PEITC-10, and PEITC-20 groups treated with 0.1% dimethyl sulfoxide (DMSO), and 10 and 20 μmole PEITC/100 μL PBS daily by oral gavage, respectively. PEITC significantly decreased tumor weights and volumes of GBM 8401 cells in mice, but did not affect the total body weights of mice. PEITC diminished the levels of anti-apoptotic proteins MCL-1 (myeloid cell leukemia 1) and XIAP (X-linked inhibitor of apoptosis protein) in GBM 8401 cells. PEITC enhanced the levels of caspase-3 and Bax in GBM 8401 cells. The growth of glioblastoma can be suppressed by the biological properties of PEITC in vivo. These effects might support further investigations into the potential use of PEITC as an anticancer drug for glioblastoma.
Tetrahydroxystilbene Glucoside Regulates Proliferation, Differentiation, and OPG/RANKL/M-CSF Expression in MC3T3-E1 Cells via the PI3K/Akt Pathway
Authors: Fan Ying-Sai , Li Qin , Hamdan Nawras , Bian Yi-Fei , Zhuang Shen , Fan Kai , Liu Zhong-Jie
Published: September 2018

Tetrahydroxystilbene glucoside (TSG) is a unique component of the bone-reinforcing herb Radix Polygoni Multiflori Preparata (RPMP). It has the ability to promote bone formation and protect osteoblasts. However, the underlying mechanism remains unclear. To better understand its biological function, we determined TSG’s effect on murine pre-osteoblastic MC3T3-E1 cells by the MTT assay, flow cytometry, FQ-PCR, Western blot, and ELISA. The results showed that TSG caused an elevation of the MC3T3-E1 cell number, the number of cells in the S phase, and the mRNA levels of the runt-related transcription factor-2 (Runx2), osterix (Osx), and collagen type I α1 (Col1a1). In addition, the osteoprotegerin (OPG) mRNA level was up-regulated, while the nuclear factor-κB ligand (RANKL) and macrophage colony-stimulating factor (M-CSF) mRNA levels were down-regulated by TSG. Furthermore, TSG activated the phosphoinosmde-3-kinase/protein kinase B (also known as PI3K/Akt) pathway, and blocking this pathway by the inhibitor LY-294002 could impair TSG’s functions in relation to the MC3T3-E1 cells. In conclusion, TSG could activate the PI3K/Akt pathway and thus promote MC3T3-E1 cell proliferation and differentiation, and influence OPG/RANKL/M-CSF expression. TSG merits further investigation as a potential therapeutic agent for osteoporosis treatment.
Additive-Free Rice Starch-Assisted Synthesis of Spherical Nanostructured Hematite for Degradation of Dye Contaminant
Authors: Matmin Juan , Affendi Irwan , Ibrahim Salizatul , Endud Salasiah
Published: September 2018

Nanostructured hematite materials for advanced applications are conventionally prepared with the presence of additives, tainting its purity with remnants of copolymer surfactants, active chelating molecules, stabilizing agents, or co-precipitating salts. Thus, preparing nanostructured hematite via additive-free and green synthesis methods remains a huge hurdle. This study presents an environmentally friendly and facile synthesis of spherical nanostructured hematite (Sp-HNP) using rice starch-assisted synthesis. The physicochemical properties of the Sp-HNP were investigated by Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), thermogravimetric analysis (TGA), field emission scanning electron microscopy (FESEM), energy dispersive X-ray spectroscopy (EDX), transmission electron microscopy (TEM), UV-Vis diffuse reflectance spectroscopy (DR UV-Vis), and nitrogen adsorption–desorption analysis. The Sp-HNP showed a well-crystallized structure of pure rhombohedral phase, having a spherical-shaped morphology from 24 to 48 nm, and a surface area of 20.04 m2/g. Moreover, the Sp-HNP exhibited enhanced photocatalytic degradation of methylene blue dye, owing to the large surface-to-volume ratio. The current work has provided a sustainable synthesis route to produce spherical nanostructured hematite without the use of any hazardous agents or toxic additives, in agreement with the principles of green chemistry for the degradation of dye contaminant.
Compliance to Prenatal Iron and Folic Acid Supplement Use in Relation to Low Birth Weight in Lilongwe, Malawi
Authors: Chikakuda Aaron Thokozani , Shin Dayeon , Comstock Sarah S. , Song SuJin , Song Won O.
Published: September 2018

Prenatal iron and folic acid (IFA) supplements are offered free to all pregnant women in Malawi to reduce maternal anemia and improve birth outcomes. We investigated the association between self-reported compliance to IFA intake and risk of low birth weight (LBW). Pregnant women who attended Bwaila Maternity Wing of Lilongwe District Hospital for delivery were recruited (n = 220). We used a questionnaire to collect self-reported information on IFA use and maternal sociodemographic data. Before delivery, blood samples for maternal hemoglobin (Hb) and folate status, and upon delivery, birth weight, and other newborn anthropometrics were measured. We used multivariable logistic regression to determine risk of LBW by prenatal IFA intake. The self-reported number of IFA pills taken during pregnancy was positively associated with Hb, but not serum and RBC folate concentration: <45, 45–89 and ≥90 pills taken corresponded with mean (SD) Hb 10.7 (1.6), 11.3 (1.8), and 11.7 (1.6) g/dL, respectively (p = 0.006). The prevalence of LBW was 20.1%, 13.5% and 5.6% for those who reported taking IFA pills <45, 45–89, and ≥90 pills, respectively (p = 0.027). Taking >60 IFA pills reduced risk of LBW delivery (OR (95% CI) = 0.15 (0.03–0.70), p = 0.033) than taking ≤30 pills. Self-reported compliance to IFA use is valid for assessing prenatal supplement program in Malawi, especially Hb status, and can reduce the rate of LBW.
Preventive Effect of Flavonol Derivatives Abundant Sanglan Tea on Long-Term High-Fat-Diet-Induced Obesity Complications in C57BL/6 Mice
Authors: Guruvaiah Ponmari , Guo Huimin , Li Daxiang , Xie Zhongwen
Published: September 2018

Sanglan Tea (SLT) is a Chinese medicine-based formulation that is consumed as a health drink for the effective management of obesity-associated complications. However, its chemical components and mechanism of action in the prevention of hepatic steatosis and obesity-related impairments have been uncertain. In this study, we aimed to unveil the chemical profile of SLT and to explore its preventive mechanism in high-fat-diet-induced non-alcoholic fatty liver disease (NAFLD) and obesity-related consequences in C57BL/6 mice. Ultrahigh-performance liquid chromatography (UHPLC) coupled to a quadrupole-orbitrap high-resolution mass spectrometry (MS) analysis of SLT indicated that analogs of quercetin and kaempferol are major compounds of flavonoids in SLT. A dietary supplement of SLT efficiently managed the blood glucose elevation, retained the serum total cholesterol (TC), LDL-cholesterol (LDL-C), and triglyceride (TG) levels, as well as aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activity, and reduced the fat storage in the liver induced by a high-fat diet. The underlying mechanism of this preventive effect is hypothesized to be related to the inhibition of over-expression of lipogenesis and adipogenesis-related genes. Overall, this study suggests that SLT, being rich in quercetin and kaempferol analogs, could be a potential food supplement for the prevention of high-fat-diet-induced NAFLD and obesity-related complications.
Association between Cognitive Restraint, Uncontrolled Eating, Emotional Eating and BMI and the Amount of Food Wasted in Early Adolescent Girls
Authors: Banna Jinan C. , Panizza Chloe E. , Boushey Carol J. , Delp Edward J. , Lim Eunjung
Published: September 2018

Understanding of behavioral factors associated with obesity is of importance in addressing this issue. This study examined the association between cognitive restraint, uncontrolled eating, emotional eating and body mass index (BMI) and amount of food plated, consumed, leftovers, and leftover food thrown into the trash (food wasted) in early adolescent girls nine to 13 years in O’ahu, Hawai’i (n = 93). Food plated, consumed, leftovers, and food wasted were estimated using a three-day mobile food record™ (mFR). Weight and height were measured to compute BMI (kg/m2). The three-factor eating questionnaire provided a score from 0 to 100 for cognitive restraint, uncontrolled eating, and emotional eating. Higher scores are indicative of greater cognitive restraint, uncontrolled eating, and emotional eating. Pearson’s correlations were computed to examine the relationship between three factor eating scores and BMI. General linear models were conducted to examine the effect of each of three-factor eating scores on food plated, consumed, leftovers, and food wasted. Cognitive restraint was positively correlated with BMI (r = 0.36, p < 0.001) and with BMI z-score (r = 0.40, p < 0.001). There were no associations between three-factor eating scores and food plated, consumed, leftovers, and food wasted at lunch. However, at dinner, total energy plated, left over, and food wasted increased by 4.24 kcal/day (p = 0.030), 1.67 kcal/day (p = 0.002), and 0.93 kcal/day (p = 0.031), respectively, with a unit increase in uncontrolled eating score. Similarly, total energy plated and energy left over at dinner increased by 3.40 kcal/day (p = 0.045) and 1.51 kcal/day (p = 0.001), respectively, with a unit increase in emotional eating score. Additional research should examine the specific roles of cognitive restraint, uncontrolled eating, emotional eating and food waste in the development of obesity in adolescents.
Synthesis of a Bone-Targeted Bortezomib with In Vivo Anti-Myeloma Effects in Mice
Authors: Wang Hua , Xiao Lifeng , Tao Jianguo , Srinivasan Venkat , Boyce Brendan F. , Ebetino Frank H. , Oyajobi Babatunde O. , Boeckman Robert K. , Xing Lianping
Published: September 2018

Multiple myeloma (MM) is the most common cancer affecting the bone and bone marrow and remains incurable for most patients; novel therapies are therefore needed. Bortezomib (Btz) is an FDA-approved drug for the treatment of patients with MM. However, its severe side effects require a dose reduction or the potential discontinuation of treatment. To overcome this limitation, we conjugated Btz to a bisphosphonate (BP) residue lacking anti-osteoclastic activity using a novel chemical linker and generated a new bone-targeted Btz-based (BP-Btz) proteasome inhibitor. We demonstrated that BP-Btz, but not Btz, bound to bone slices and inhibited the growth of MM cells in vitro. In a mouse model of MM, BP-Btz more effectively reduced tumor burden and bone loss with less systemic side effects than Btz. Thus, BP-Btz may represent a novel therapeutic approach to treat patients with MM.
Fabrication of Reactive Poly(Phenyl-Substituted Siloxanes/Silsesquioxanes) with Si‒H and Alkoxy Functional Groups via the Piers–Rubinsztajn Reaction
Authors: Yi Minghao , Chen Xunjun , Wu Shufang , Ge Jianfang , Zhou Xinhua , Yin Guoqiang
Published: September 2018

Poly(phenyl-substituted siloxanes/silsesquioxanes) are obtained by the Piers–Rubinsztajn (PR) reaction of hydrogen-containing siloxanes (HCS) with diphenyldialkoxysilanes such as diphenyldimethoxysilane and diphenyldiethoxysilane catalyzed by tris(pentafluorophenyl)borane. 29Si nuclear magnetic resonance (NMR) spectroscopy, gel permeation chromatography, and refractive index analysis revealed that apart from phenyl substituents and complex structures such as molecular bridges composed of D2Ph2[(C6H5)2Si(OSi)2], structures also existed in these polymers, having high refractive indexes (above 1.50) and high molecular weights (75.60 KDa·mol−1). As revealed by thermogravimetric analysis, these polymers have high thermal stability as well, with temperature at 5% mass loss (T5%) increasing by 182.5 °C and Rw (residual weight ratio) increasing by 5.17 times from 14.63% to 75.60%, as compared to HCS, exhibiting its potential application as resins for resisting strong heat. Such high-refractive-index and temperature-resistant poly(phenyl-substituted siloxanes/silsesquioxanes) with Si–H and alkoxy functional groups can be used as a good addition-type crosslinking agent with adhesion-promoting properties or a special curing agent that can solidify silicone materials through simultaneous addition and condensation reactions, which has potential application in the light-emitting diode (LED) packaging industry.
Kinetic Monte Carlo Simulation Based Detailed Understanding of the Transfer Processes in Semi-Batch Iodine Transfer Emulsion Polymerizations of Vinylidene Fluoride
Authors: Brandl Florian , Drache Marco , Beuermann Sabine
Published: September 2018

Semi-batch emulsion polymerizations of vinylidene fluoride (VDF) are reported. The molar mass control is achieved via iodine transfer polymerization (ITP) using IC4F8I as chain transfer agent. Polymerizations carried out at 75 °C and pressures ranging from 10 to 30 bar result in low dispersity polymers with respect to the molar mass distribution (MMD). At higher pressures a significant deviation from the ideal behavior expected for a reversible deactivation transfer polymerization occurs. As identified by kinetic Monte Carlo (kMC) simulations of the activation–deactivation equilibrium, during the initialization period of the chain transfer agent already significant propagation occurs due to the higher pressure, and thus, the higher monomer concentration available. Based on the kMC modeling results, semi-batch emulsion polymerizations were carried out as a two pressure process, which resulted in very good control of the MMD associated with a comparably high polymerization rate.
Miscibility and Nanoparticle Diffusion in Ionic Nanocomposites
Authors: Karatrantos Argyrios , Koutsawa Yao , Dubois Philippe , Clarke Nigel , Kröger Martin
Published: September 2018

We investigate the effect of various spherical nanoparticles in a polymer matrix on dispersion, chain dimensions and entanglements for ionic nanocomposites at dilute and high nanoparticle loading by means of molecular dynamics simulations. The nanoparticle dispersion can be achieved in oligomer matrices due to the presence of electrostatic interactions. We show that the overall configuration of ionic oligomer chains, as characterized by their radii of gyration, can be perturbed at dilute nanoparticle loading by the presence of charged nanoparticles. In addition, the nanoparticle’s diffusivity is reduced due to the electrostatic interactions, in comparison to conventional nanocomposites where the electrostatic interaction is absent. The charged nanoparticles are found to move by a hopping mechanism.
Locomotion of a Cylindrical Rolling Robot with a Shape Changing Outer Surface
Authors: Puopolo Michael G. , Jacob Jamey D. , Gabino Emilio
Published: September 2018

A cylindrical rolling robot is developed that generates roll torque by changing the shape of its flexible, elliptical outer surface whenever one of four elliptical axes rotates past an inclination called trigger angle. The robot is equipped with a sensing/control system by which it measures angular position and angular velocity, and computes error with respect to a desired step angular velocity profile. When shape change is triggered, the newly assumed shape of the outer surface is determined according to the computed error. A series of trial rolls is conducted using various trigger angles, and energy consumed by the actuation motor per unit roll distance is measured. Results show that, for each of three desired velocity profiles investigated, there exists a range of trigger angles that results in relatively low energy consumption per unit roll distance, and when the robot operates within this optimal trigger angle range, it undergoes minimal actuation burdening and inadvertent braking, both of which are inherent to the mechanics of rolling robots that use shape change to generate roll torque. A mathematical model of motion is developed and applied in a simulation program that can be used to predict and further understand behavior of the robot.
3D Façade Labeling over Complex Scenarios: A Case Study Using Convolutional Neural Network and Structure-From-Motion
Authors: Lotte Rodolfo Georjute , Haala Norbert , Karpina Mateusz , Aragão Luiz Eduardo Oliveira e Cruz de , Shimabukuro Yosio Edemir
Published: September 2018

Urban environments are regions in which spectral variability and spatial variability are extremely high, with a huge range of shapes and sizes, and they also demand high resolution images for applications involving their study. Due to the fact that these environments can grow even more over time, applications related to their monitoring tend to turn to autonomous intelligent systems, which together with remote sensing data could help or even predict daily life situations. The task of mapping cities by autonomous operators was usually carried out by aerial optical images due to its scale and resolution; however new scientific questions have arisen, and this has led research into a new era of highly-detailed data extraction. For many years, using artificial neural models to solve complex problems such as automatic image classification was commonplace, owing much of their popularity to their ability to adapt to complex situations without needing human intervention. In spite of that, their popularity declined in the mid-2000s, mostly due to the complex and time-consuming nature of their methods and workflows. However, newer neural network architectures have brought back the interest in their application for autonomous classifiers, especially for image classification purposes. Convolutional Neural Networks (CNN) have been a trend for pixel-wise image segmentation, showing flexibility when detecting and classifying any kind of object, even in situations where humans failed to perceive differences, such as in city scenarios. In this paper, we aim to explore and experiment with state-of-the-art technologies to semantically label 3D urban models over complex scenarios. To achieve these goals, we split the problem into two main processing lines: first, how to correctly label the façade features in the 2D domain, where a supervised CNN is used to segment ground-based façade images into six feature classes, roof, window, wall, door, balcony and shop; second, a Structure-from-Motion (SfM) and Multi-View-Stereo (MVS) workflow is used to extract the geometry of the façade, wherein the segmented images in the previous stage are then used to label the generated mesh by a “reverse” ray-tracing technique. This paper demonstrates that the proposed methodology is robust in complex scenarios. The façade feature inferences have reached up to 93% accuracy over most of the datasets used. Although it still presents some deficiencies in unknown architectural styles and needs some improvements to be made regarding 3D-labeling, we present a consistent and simple methodology to handle the problem.
Seismological Observations of Ocean Swells Induced by Typhoon Megi Using Dispersive Microseisms Recorded in Coastal Areas
Authors: Lin Jianmin , Fang Sunke , Li Xiaofeng , Wu Renhao , Zheng Hong
Published: September 2018

Typhoons in the western Pacific Ocean can generate extensive ocean swells, some of which propagate toward Taiwan, Luzon, and the Ryukyu Islands, impacting the coasts and generating double-frequency (DF) microseisms. The dispersion characteristics of DF microseisms relevant to the propagation of ocean swells were analyzed using the fractional Fourier transform (FrFT) to obtain the propagation distance and track the origins of typhoon-induced swells through seismic observations. For the super typhoon Megi in 2010, the origin of the induced ocean swells was tracked and localized accurately using seismic records from stations in eastern Taiwan. The localized source regions and calculated wave periods of the ocean swells are in good agreement with values predicted by ERA5 reanalysis from the European Centre for Medium-Range Weather Forecasts (ECMWF). However, localized deviations may depend on the effective detection of dispersive DF microseisms, which is tied to both coastline geometry and the geographic locations of seismic stations. This work demonstrates the effectiveness of seismological methods in observing typhoon-induced swells. The dispersion characteristics of DF microseisms recorded by coastal stations could be used as a proxy measure to track and monitor typhoon-induced swells across oceans.
Scale Matters: Spatially Partitioned Unsupervised Segmentation Parameter Optimization for Large and Heterogeneous Satellite Images
Authors: Georganos Stefanos , Grippa Tais , Lennert Moritz , Vanhuysse Sabine , Johnson Brian , Wolff Eléonore
Published: September 2018

To classify Very-High-Resolution (VHR) imagery, Geographic Object Based Image Analysis (GEOBIA) is the most popular method used to produce high quality Land-Use/Land-Cover maps. A crucial step in GEOBIA is the appropriate parametrization of the segmentation algorithm prior to the classification. However, little effort has been made to automatically optimize GEOBIA algorithms in an unsupervised and spatially meaningful manner. So far, most Unsupervised Segmentation Parameter Optimization (USPO) techniques, assume spatial stationarity for the whole study area extent. This can be questionable, particularly for applications in geographically large and heterogeneous urban areas. In this study, we employed a novel framework named Spatially Partitioned Unsupervised Segmentation Parameter Optimization (SPUSPO), which optimizes segmentation parameters locally rather than globally, for the Sub-Saharan African city of Ouagadougou, Burkina Faso, using WorldView-3 imagery (607 km2). The results showed that there exists significant spatial variation in the optimal segmentation parameters suggested by USPO across the whole scene, which follows landscape patterns—mainly of the various built-up and vegetation types. The most appropriate automatic spatial partitioning method from the investigated techniques, was an edge-detection cutline algorithm, which achieved higher classification accuracy than a global optimization, better predicted built-up regions, and did not suffer from edge effects. The overall classification accuracy using SPUSPO was 90.5%, whilst the accuracy from undertaking a traditional USPO approach was 89.5%. The differences between them were statistically significant (p < 0.05) based on a McNemar’s test of similarity. Our methods were validated further by employing a segmentation goodness metric, Area Fit Index (AFI)on building objects across Ouagadougou, which suggested that a global USPO was more over-segmented than our local approach. The mean AFI values for SPUSPO and USPO were 0.28 and 0.36, respectively. Finally, the processing was carried out using the open-source software GRASS GIS, due to its efficiency in raster-based applications.
Long-Term Changes in Water Clarity in Lake Liangzi Determined by Remote Sensing
Authors: Xu Xuan , Huang Xiaolong , Zhang Yunlin , Yu Dan
Published: September 2018

Water clarity (via the Secchi disk depth, SDD) is an important indicator of water quality and lake ecosystem health. Monitoring long-term SDD change is vital for water quality assessment and lake management. In this study, we developed and validated an empirical model for estimating the SDD based on Landsat ETM+ and OLI data using the combination of band ratio of the near-infrared (NIR) band to the blue band and the NIR band. Time series data of remotely estimated SDD in Lake Liangzi were retrieved from 2007 to 2016 using the proposed models based on forty Landsat images. The results of the Mann–Kendall test (p = 0.002) and linear regression (R2 = 0.352, p < 0.001) indicated that the SDD in Lake Liangzi demonstrated a significant decreasing trend during the study period. The annual mean SDD in Lake Liangzi was significantly negatively correlated with the population (R2 = 0.530, p = 0.017) and gross domestic product (R2 = 0.619, p = 0.007) of the Lake Liangzi basin. In addition, water level increase and the flood have an important effect on SDD decrease. Our study revealed that anthropogenic activities may be driving factors for the long-term declining trend in the SDD. Additionally, floods and heavy precipitation may decrease the SDD over the short term in Lake Liangzi. A declining trend in the SDD in Lake Liangzi may continue under future intense anthropogenic activities and climate change such as the extreme heavy precipitation event increase.