bluuebunny/crossref_metadata_2025 huggingface dataset:
Molecular docking, synthesis and study of substituted 1-Methyl-6-Oxo-2-[(2z)-2-(3-Oxo-4-Phenylazetidin-2-Ylidene)Hydrazinyl]-4-Phenyl-1,6-dihydropyrimidine-5-carbonitrile derivatives
Authors: Holam M. R. , Santhoshkumar V. , Killedar S. G.
Published: October 2022

Synthesis of Substituted 2-[(2-chloro-4-oxo-3-phenylazetidin-1-yl)amino]-1-methyl-6-oxo-4-phenyl-1,6-dihydropyrimidine-5-carbonitrile(6a-r) and 1-methyl-6-oxo-2-[(4-oxo-2-phenyl-1,3-thiazolidin-3-yl)amino]-4-phenyl-1,6-dihydropyrimidine-5-carbonitrile (7a-o)Derivatives was completed using aromatic aldehyde, ethylcyanoacetate and thiourea in absolute ethanol as per the standard procedure.The completion of reactionmonitored by TLC and structure were confirmed by spectroscopic method viz FT-IR and 1H NMR and elemental analysis.The affinity of synthesized compounds with CDK4 protein was predicted by molecular docking studies. The docking results showed that compound 6l, 6p and 6r has highest affinity with CDK4 protein with minimum energy with good hydrogen bonding interaction.
Good beverage in relax activity for lowering blood sugar level (Cane Juice After Exposure by floated virgin coconut oils and dipped piezoelectric transducer)
Authors: Arifin Syamsul , Sudijandoko Andun
Published: October 2022

The detecting blood glucose level with a peripheral flow sample (PBGL) is fast technique, easy and cheap, that can be detecting after Athlete aerobic activity, relax, after drinking 10 mL ordinary cane juice (OC), and after drinking 10 mL cane juice exposure ultrasonic (CC) by transducer of floated Virgin Coconut Oils and combine dipped Piezoelectric (Tr. FVCOP), where the CC was a new technic made beverage in test tube. This research can be compared with previous research using animal such as Mice, which was developed from the Mice aerobic activity that were force after drank (as sonde) 0,25 mL CC (Syamsul Arifin, et al, 2019), where the CC was the results of previous research of OC radiation by dipped transducer 12 Knobs (Tr. R12K) for 3 hours get a pH value of CC = 8.5 (Sriundy Made, et al, 2017) and according to the results of previous studies, activities like this,. The result of the aerobic activities Mice and sonde of CC was more active than the other groups. However, research the Mice in relax who sonde 0.25 mL CC (Syamsul Arifin, et al, 2019) had different and result from Badminton athletes who drank OC (Hermawati, 2018).
Effectiveness of corporate social responsibility performance in oil and gas companies in north Kalimantan
Authors: Purwanti Sri , Abdoellah Oekan S , Asdak Chay , Cahyandito M. Fani
Published: October 2022

Development effort oil and gas experience enhancement enough fast, existence activity the Fulfill needs energy national. Indonesia is a developing country have backup oil and gas that became support growth economy and development however has the potential to cause impact to environment especially in area around industrial areas. PT. MEP is one of the company oil and gas operating in North Kalimantan in every the operation attempted create balance environment with draft give sustainable energy, however special CSR program performance field  environment implemented life not yet measurable by certain because no there is guide special about Thing that . Focus study this is exploratory and descriptive. Researcher using engineering models data analysis with to do data collection, data reduction, past data presentation withdrawal conclusions (Miles and Huberman, 1992). Based on results research that has been conducted could concluded that environmental CSR performance already effective, implemented with good with implementing Governance Company sustainable
impact of family resilience interventions on individual beliefs and medication adherence in pulmonary TB patients
Authors: Rachmawati Dhian Satya , Nursalam Nursalam , Amin Muhammad , Hargono Rachmat , Rustam Muh Zul Azhri , Riestiyowati Maya Ayu
Published: October 2022

Background: Family resilience has a role in maintaining a balance between stress and optimism as well as family strength. In this case, it is expected that family resilience can increase family independence in taking care for family members suffering from pulmonary TB thus the patients eventually have good belief to adhere to the treatment process. Furthermore, the purpose of this study was to determine the effect of family resilience interventions on belief and adherence to treatment of patients with pulmonary TB. Research method: This research applied a quasi-experimental research design involving 60 respondents suffering from pulmonary TB as the research samples. These samples were selected randomly in the Surabaya area. Meanwhile, the independent variables studied in this study were the intervention of family resilience, while the dependent variables are the individual beliefs and medication adherence. Furthermore, the research instrument used to collect the data was an intervention module and a modified questionnaire. After obtaining the data, they were analyzed using paired t-test, Wilcoxon test, and Mann Whitney with a significance of P of less than 0.05.
Effect of respiratory muscle training on ventilatory function in women post mastectomy
Authors: Al-Najar Khulood M. , Ibraheem Maher H. , Zaki Raef Mourad , Mohamed Dalia Ahmed , Hady Azza Abdel Aziz Abdel , EL-Nahas Nesreen Ghareeb
Published: October 2022

Mastectomy is one of the widely spread surgeries to remove breast cancer, however, this type of intervention disturbs the ventilatory function of the patient after surgery. The role of physical therapy is crucial in such cases as to improve the function of the respiratory system, and chest expansion, decrease the severity of dyspnea, and provide better health after mastectomy. Purpose: to study the effect of respiratory muscle training by using (The Breather) on ventilatory functions in women after mastectomy. Objectives: 40 women with unilateral post-mastectomy were randomly selected from Baheya Center with an age range from (40-50) years old. (Received radiotherapy /chemotherapy and physical therapy sessions), divided into 2 equal groups (each group=20). Methodology: Group A received respiratory muscle training with the breather device with physical therapy rehabilitation and Group B received physical therapy rehabilitation only. Both groups received sessions twice weekly for 12 weeks. Equipment used for evaluation: ventilatory function measuring device (Spirometer) used to measure ventilatory function (FEV1, FVC, FEV1/FVC, MVV), Tape measurement used to measure chest expansion, and Functional Assessment of Chronic Illness Therapy - Dyspnea-10 item (FACIT-Dyspnea) Questionnaire.
2014 - 2016: Brasil no centro do mundo esportivo dos megaeventos
Authors: Duarte Bruno Inácio , Bendrath Eduard Angelo
Published: October 2022

O objetivo desse trabalho foi o de analisar publicações científicas brasileiras acerca da realização da Copa do Mundo 2014 e Olimpíadas Rio 2016 e suas possíveis contribuições para o cenário nacional. Optou-se pelo uso do método de revisão narrativa utilizando como fator de busca artigos qualificados nos estratos superiores do sistema Qualis da área da Educação Física. Os resultados mostraram que as publicações concentraram-se em aspectos de política e gestão, infraestrutura, e mídia, não podendo ser encontrado um consenso sobre os resultados da decisão do país em sediar 2 megaeventos em um curto espaço de tempo.
Como se constrói um craque: o caso de Leônidas da Silva
Authors: Da Silva Diana Mendes Machado
Published: October 2022

Leônidas da Silva, negro e oriundo do subúrbio carioca foi o primeiro craque do futebol por suas atuações em clubes importantes e na seleção brasileira. Sobre ele circularam imagens em periódicos como O Cruzeiro, sobretudo após sua participação na Copa do Mundo de 1938. Suas imagens revelam que o jogador foi figurado como craque no momento da profissionalização do futebol e do estabelecimento de uma cultura midiática. Além de confirmarem a excelência do jogador e os investimentos feitos pela imprensa, suas fotografias ofereceram visibilidade positiva para pessoas de pele negra. A trajetória de Leônidas transcendeu o campo futebolístico ao dialogar com alguns dos símbolos, valores e práticas do período entre guerras.
The Application of Geologic Mapping, Core Logging, and 3-D Geoscientific Data Integration in the Exploration and Resource Expansion of Porphyry Copper-(Gold) Deposits: Examples from Recent Discoveries in Ecuador and Chile
Authors: Garwin Steve , Whistler Benn , Ward Jason , Vaca Santiago , Mather Nick , Chand Meraaj , Silva José , Rosero Bayardo , Cruz Alfredo , Guachamin Alvaro , Castro Carlos Diaz , Chafla Alex , Mantilla Santiago , Aguilar Leonardo , Easterday Christian , Leighton Melanie , Aravena Andrea , Tapia Miguel , Vázquez Cristian , Miñano Tapia Enrique , Salas Pablo , Olivares David , Costa Sebastian , Beeson John , Sheerin Kirsty , Wallace Madeline , McKie Chris
Published: October 2022

The collection of accurate geologic data is critical in minerals exploration. The successful visualization, integration, and interpretation of quantitative vein abundance data, associated selvages of wall-rock alteration mineralogy, sulfide mineral proportions, and metal zoning facilitate the path to discovery and orebody delineation. The application of the Anaconda method, developed by the Anaconda Copper Mining Company geologists in the 1960s, to geologic mapping and drill core logging has facilitated the discovery and resource expansion in the giant Alpala porphyry Cu-Au-Ag deposit in northern Ecuador and the Cortadera porphyry Cu-Au-Mo deposit cluster in northern Chile. In both porphyry systems, high-grade zones have been targeted through the delineation of an intrusion and vein chronology that allows for the recognition of early-stage causal intrusions, zones of abundant porphyry-style quartz veins, and elevated chalcopyrite to pyrite ratios. Increased amounts of molybdenum, as molybdenite along fractures and in quartz veins, as well as anhydrite veins and disseminations, correlate with proximity to the deposit cores. The field-based methods presented in this article have proven useful in porphyry exploration for decades. The application of the Anaconda method of geologic mapping and core logging by geologists can assist in the targeting of high-grade cores of deposits and improved estimation of metal resources.
Spatial aeolotropy of UII and UPI based buffer gradient analysis on urban sprawl of two metropolitan cities of Kerala
Authors: Prasad T K , Jayalakshmi V K
Published: October 2022

Urbanization is integrally connected to three pillars of sustainable development: economic development, social development and environmental protection. Haphazard urban expansion leads to rapid sprawl, pollution and environmental degradation together with unsustainable production and consumption pattern. A comprehensive assessment and proper methodology is inevitable for urban planning. This study is to identify spatiotemporal trends of urban expansion and intensity in two Metropolitan cities: Thiruvananthapuram and Cochin city region (Kerala), To measure the magnitude and pace of urban growth and Urban proportional Index (UPI) and Urban Intensity Index (UII) were developed. GIS based buffer analysis was adopted in this study. Each buffer zone was employed as a basic spatial unit to characterize distance dependent urban growth behaviour with their UPI and UII values for a given time period. The results indicate that two distinct phases of urbanization are discernible in these. The trends in Urban behaviour of Thiruvananthapuram and Cochin are to be given grave concern and study being the administrative as well as the commercial capital of Kerala state respectively. Keywords Spatial aeolotropy, sustainable development, sprawl, spatiotemporal, urban proportional index, urban intensity index
Morphometric analysis for peak discharge estimation of sub and micro watersheds of Vedavathy river sub basin, Karnataka
Authors: Mayachar Shilpashree K , Nandini N , Ramesh K S
Published: October 2022

IRS and GIS technology are extensively used for basin analysis which helps in monitoring the development and management of watershed and its catchment areas. The present study was carried to estimate peak discharge of two mini and micro watershed of the Krishna river basin, the two watersheds selected for the above study are Chikkur sub-watershed and Lailapura micro watershed which forms a part of Vedavathy river sub-basin and falls under Krishna river basin lying in between Karagunda and Hiriyur village of Chikamagalur & Hassan districts in Karnataka. The satellite image used for the study are Ortho_rectified Cartosat -1(2.5m), digital elevation model (DEM) data & LISS-IV (5.86m) are used for extraction of basin Morphometric parameters, database generation using NRIS resource layers and Automatic delineation of the watershed under Arc GIS Environment. Morphometric Analysis of Chikkur subwatershed have shown less relief ratio, high ruggedness number, time of concentration, drainage density stream frequency, mean bifurcation ratio, and less form factor. Lailapura micro watershed has shown high relief ratio, form factor and time of concentration fewer ruggedness numbers, stream frequency. The peak discharge of Chikkur subwatershed is 46.56 cusecs and Lailapura micro watershed is 10.31 cusecs for 160mm of rain respectively. Keywords: ­ sub­watershed, Krishna river basin, Vedavathy river sub­basin, and Morphometric Analysis, peak discharge estimation
Invariance-Based Approach Explains Empirical Formulas from Pavement Engineering to Deep Learning
Authors: Velasquez Edgar Daniel Rodriguez , Kosheleva Olga , Kreinovich Vladik
Published: October 2022

In many application areas, there are effective empirical formulas that need explanation. In this paper, we focus on two such challenges: neural networks, where a so-called softplus activation function is known to be very efficient, and pavement engineering, where there are empirical formulas describing the dependence of the pavement strength on the properties of the underlying soil. We show that similar scale-invariance ideas can explain both types of formulas – and, in the case of pavement engineering, invariance ideas can lead to a new formula that combines the advantages of several known ones.
Review of Li Yi’s Republican China as Method (Zuowei fangfa de minguo 作為方法的民國)
Authors: Zhang Ruirui
Published: October 2022

Li Yi’s book Republican China as a Method serves as an innovative research method to deeply understand modern Chinese literature. It emphasizes the interaction between the materialistic social and cultural mechanism and the spiritual and personal creativity of literary creation. Although it only provides a start of the theoretical research paradigm, it presents a brave attempt by Mainland Chinese scholars to pursue subjective research.
IMPACTO DA NAVEGAÇÃO DE PACIENTES COM CÂNCER DE MAMA DURANTE E APÓS A PANDEMIA SARS-COV-2 EM UMA INSTITUIÇÃO DE ONCOLOGIA
Authors: Cruz Sara Raabe Gomes , Menezes Adriel dos Santos , Castilho Gabriel Inácio , Fidelis Italo Jose Freire , Varela Edilene Coelho Duarte , Freitas Ellen Albuquerque de
Published: October 2022

Introdução: Coronavírus são vírus de RNA que eram conhecidos por causar doenças respiratórias leves em humanos. Em dezembro de 2019, foi identificado um novo tipo de coronavírus, o SARS-CoV-2, e em março de 2020 decretada pandemia por SARS-CoV-2. Esse cenário prejudicou a continuidade de tratamentos, como o câncer de mama, momento este que Programas como o de Navegação tornaram-se uma ferramenta indispensável para auxiliar os pacientes em toda a trajetória do tratamento. Objetivo: Avaliar o impacto da Navegação de Pacientes no tratamento de pacientes com câncer de mama durante e após a pandemia SARS-CoV-2 em uma instituição referência em Oncologia em Manaus (AM). Métodos: Estudo descritivo, analítico, de abordagem quantitativa, retrospectiva e prospectiva, realizado no Serviço de Navegação em enfermagem e na Sala de Infusão de Quimioterapia no período de setembro de 2020 a março de 2021, separando-se em dois grupos: pacientes atendidos durante e após o período da pandemia. Resultado: Foram incluídos 100 participantes no grupo 1 e 81 no grupo 2. A população abrangeu mulheres (99%), com idade média de 54 anos do grupo 1 e 53 anos relacionado ao grupo 2, com tipo histológico mais prevalente carcinoma ductal invasivo de mama nos dois grupos, e os principais motivos que levaram os pacientes a procurar atendimento no Serviço de Navegação foram: marcação de consulta para o Mastologista (84 registros de atendimento no grupo 1, representando 34,8% no grupo 1 e 50 atendimentos no grupo 2 – 34,2%) e marcação de consulta para Agendamento Cirúrgico (19,9%, registrados 48 atendimentos no grupo 1 e 19,8% no grupo 2, com 29 atendimentos). A Escala de Avaliação de Necessidade de Navegação apontou que, no grupo 1, 30% (n: 30) dos participantes não teriam necessidade de navegação e 46% (n: 46) possuem necessidade de navegação nível 1. No grupo 2, 30,86% (n=25) dos participantes não teriam necessidade de navegação e 59,25% dos participantes (n: 48) com necessidade de navegação nível 1. Conclusão: O Programa de Navegação mostrou-se essencial para as participantes, visto que as demandas mais incidentes implicavam na continuidade de seu tratamento em tempo hábil, auxiliando com que as mesmas não se perdessem durante a pandemia em seu plano terapêutico, em virtude da complexidade no momento atípico vivido nos anos de 2020 e 2021.
STUDI KUALITATIF FAKTOR KINERJA KARYAWAN PADA PT. XYZ SELAMA MASA PANDEMI COVID-19
Authors: Al Faruq Alvin
Published: October 2022

In the modern era of Covid-19 and the ongoing new normal modernization process, the business world is required to be more responsive to all innovations that occur in order to be able to survive, continue to develop, and achieve its goals. Therefore, the company will be able to compete with other businesses if the performance of its employees is competitive. This study aims to identify employee performance factors at PT. XYZ during the Covid-19 pandemic. This research is a qualitative descriptive study. Determination of the subject through the use of deliberately selected sampling. Interview and observation are the two main methods used in the data collection process. The findings show that in terms of leadership style, their leaders encourage them to take the initiative, and their leaders let their employees carry out tasks in a way that employees find most effective. Relations between employees in the workplace are still quite good. For example, if one employee is having a hard time, there are several other employees who care or are willing to help, and that employee is not hindered in his work. This will affect employee performance, and employees will feel more comfortable working if facilities are available. Besides, PT. XYZ shows the company's employees that they are not given any gifts or rewards in the company as part of the work motivation program they participate in.
ANÁLISIS Y REFLEXIÓN SOBRE EL NUEVO CURRÍCULO DE EDUCACIÓN FÍSICA
Authors: Pérez-Pueyo Ángel , Hortigüela Alcalá David , Casado Berrocal Oscar , Heras Bernardino Carlos , Herrán Álvarez Israel
Published: October 2022

La nueva Ley Orgánica 3/2020, de 29 de diciembre, por la que se modifica la Ley Orgánica 2/2006, de 3 de mayo, de Educación (LOMLOE) ha conseguido, una vez más, generar sensación de vértigo en el profesorado. Sin embargo, se abre de nuevo el debate sobre qué hay que hacer y cómo, debido a los cambios estructurales establecidos en el diseño curricular y los elementos que lo componen, así como el enfoque de los desarrollos curriculares de las materias, y en concreto de la Educación Física (EF). En el presente manuscrito se plantean los principales cambios curriculares de esta nueva ley, reflexionando sobre sus principales aportes en la práctica de la EF. Se abordan tanto los enfoques competenciales como los distintos elementos del currículo, desarrollando de manera práctica diferentes tipos de situaciones de aprendizaje. Es indudable que la EF cobra una especial relevancia con la nueva legislación, lo que supone una gran oportunidad para potenciar la motricidad, desde una visión pedagógica, y así seguir promoviendo y generando un aprendizaje vivencial, significativo y perdurable en nuestro alumnado.
Pengaruh Model Problem Based Learning Terhadap Kemampuan Berpikir Kreatif Matematis Siswa pada Materi Kubus dan Balok
Authors: Selfiani Selfiani , Machmud Tedy , Resmawan Resmawan , Ismail Yamin
Published: October 2022

This study discusses the effect of the Problem Based Learning model on students' mathematical creative thinking skills on cube and cuboid material. The research was carried out using an experimental method involving students of SMP Negeri 3 Limboto Barat as research subjects. The research design used is Post Test Only Control Design. Sampling was carried out using the Simple Random Sampling technique. Measuring mathematical creative thinking ability is done using a test instrument that has met the requirements of item validity and instrument reliability requirements. The results showed that applying the Problem-Based Learning model in learning significantly influenced students' creative thinking skills on cube and cuboid material. This can be seen from students' mathematical creative thinking ability in learning using the Problem-Based Learning model, which is higher than students' mathematical creative thinking ability in direct learning.
Deskripsi Kemampuan Penemuan Konsep Siswa pada Materi Turunan Fungsi Aljabar
Authors: Dali Sri Maulana , Ismail Sumarno , Oroh Franky Alfrits , Mohidin Abdul Djabar
Published: October 2022

This study aims to describe students' discovery abilities in the learning process and when facing problems in the material derived from algebraic functions. The research was carried out in one of the Senior high schools in Gorontalo. This research is a type of qualitative descriptive research. The subjects of this study were students of class XI who opened 318 people. The techniques used in data collection are initial tests, interviews, documentation, and observation. Data analysis techniques in this study are data reduction, data presentation and conclusions. The results showed that students' discovery abilities on the derivative material of algebraic functions varied. Some have high abilities, medium abilities, and low abilities, but in general, they are dominated by students who have moderate abilities.
The effect of taxifolin on oxidative sciatic nerve damage induced by cobalt chloride in rats: a biochemical and histopathological evaluation
Authors: Tanoğlu Ceyda , Ersoy Alevtina , Çoban Taha , Yazıcı Gülce , Mammadov Renad , Süleyman Bahadır
Published: October 2022

Cobalt is a trace element that increases lipid peroxidation and
malondialdehyde levels and reduces the antioxidant defense mechanisms of nerve cells. High levels of cobalt exposure may cause peripheral neuropathy, but the mechanism behind this has not yet been elucidated. Taxifolin is a flavonoid whose antioxidant and anti‑inflammatory properties are well‑known. We aimed to investigate the effect of taxifolin on cobalt‑induced oxidative sciatic nerve damage. Eighteen albino male Wistar rats were assigned to three groups: Control, Cobalt, and Taxifolin + Cobalt groups. Total oxidant and total antioxidant status and levels of malondialdehyde, total glutathione, and superoxide dismutase were measured to determine the effect of taxifolin on
cobalt‑induced sciatic nerve injury. The following statistically significant effect of taxifolin was observed: It prevented cobalt‑induced oxidative sciatic nerve damage by reducing malondialdehyde levels and total oxidant status and increasing total antioxidant status, total glutathione levels, and superoxide dismutase levels. In a histopathological analysis, we observed similar findings in Control and Taxifolin + Cobalt groups. We determined that taxifolin is effective in preventing cobalt‑induced oxidative damage in sciatic nerve injury.
Investigation Of Thyroid Hormones, Diabetic Parameters And Other Anthropometric Parameters In The Sera Of Young Women With 2 Diabetes Mellitus
Authors: Sahib Ounce Hussein , Al-Ameri Salam. A. H , Abdullah Amer Hasan , Tahir Noor Thair
Published: October 2022

Diabetes mellitus: are a group of metabolic disease described by constant hyperglycaemia with changes in proteins, lipid, and carbohydrate caused by insulin secretion deficiencies. The purpose of the study is to check the level of anthropometric variables (Age, Body Mass Index, Waist circumference and waist to hip ratio), the variables to study T2DM ( FBS, HbA1C, Insulin and HOMA-IR) in other hand, study of thyroid hormones ( T3,T4) and pituitary hormone (TSH)  that effect on and effected by T2DM. This study involved collecting (140) samples (80) patients females diagnosed with T2DM and (60) samples of healthy females, all samples were collected from subjects of the same age group P?0.05 was used to determine whether the study's findings were significant. The difference in age between the two groups was not significant (P>0.05), while anthropometric characteristics showed highly significant differences (P<0.01) for the other parameters the level of glucose, insulin, HbA1C, HOMA-IR, T4 and TSH were substantially higher (P<0.05) in patients females than in control, T3 level was non-significant (P>0.05) effect. From the collected information it is clear that weight and it is variables have a big effect and conceder as a reason for T2DM, the study of FBS and HbA1C is done to give evidence  that the harm happened in the pancreas makes the body unable to digest glucose. The insulin is secreted in patients more than control and it  insured that the reason made it unable to work is the activity of insulin resistance , the interruption of some auto immune effect causes the elevation in IR and that’s  makes the insulin unable to do his job in the body and decrease the level of glucose. The level of TSH raised and T4 decreased in T2DM patients and that back to the fact that the thyroid hormones join in the metabolism of glucose and the dysfunction in the work of this gland effect by several ways on T2DM.
New hybrid Filtering Methods to remove noise from Digital Images
Authors: Rasheed Ahmmad , Essa Essa Ibrahim , Jumaa Borhan F.
Published: October 2022

Using hybrid digital filtering techniques to reduce the amount of time a patient is exposed to radiation. If the patient is exposed to radiation for an extended length of time, his life will be jeopardized. Noise reduction in the photos is necessary when asked to lower the high radiation dosage and time it takes, which hides some of the right information from the physician and makes it difficult for him to appropriately analyze it. As a consequence, pre-processing has become the most significant item in digital image processors, and in this research, we offer a novel hybrid technology approach to decrease noise caused when photos are captured with medical equipment or when they are transferred. While respecting the image's edges, the resulting noise of the salt and pepper type. The statistical quantity measurements, Peak Signal-to-Noise Ratio (PSNR), and Root Mean Square Error (RMSE) are used to assess the enhanced picture quality. To illustrate this method, take 0.08 salts and pepper noise and compute it as MSE it becomes 2.58 and PSNR 202.67, which indicates that this method is better than others at removing higher noise as well.
Food effect risk assessment in preformulation stage using material sparing µFLUX methodology
Authors: Jankovsky Corinne , Tsinman Oksana , Thakral Naveen
Published: October 2022

The intake of food and meal type can strongly impact the bioavailability of orally administered drugs and can consequently impact drug efficacy and safety. During the early stages of drug development, only a small amount of drug substance is available, and the solubility difference between fasted state simulated intestinal fluid and fed state simulated intestinal fluid may provide an early indication about the probable food effect. But higher drug solubility in fed state simulated intestinal fluid may not always results in an increased oral absorption. In the present research, we demonstrated using 11 model compounds that in addition to the drug dissolution in biorelevant media, the evaluation of the diffusion flux of a drug in solution, across artificial lipid coated membrane, where only the unbound drug crosses the membrane, is a reliable way to predict the food effect. Although, the combination of dissolution and diffusion flux may not reliably predict the food effect in case of drugs undergoing intestinal metabolism or when transporters are involved in the drug absorption, the technique generally provides good information about the food effect at very early stages of drug development that may help in designing a clinical plan by adjusting the drug dose in the fed state.
Assessment of the economic activity in the Polish banking sector during the COVID-19 pandemic on the basis of business tendency surveys
Authors: Hamulczuk Mariusz , Idzik Marcin
Published: October 2022

One of the areas of the economy affected by the COVID-19 pandemic is the banking sector. The aim of the study presented in the article is to answer the questions: what was the perception of the economic situation in the banking sector in Poland during the crisis caused by the COVID-19 pandemic in the light of the results of business tendency surveys, and what determined its changes over time. The research was carried out on the basis of business tendency surveys conducted by Statistics Poland and Kantar Polska in the years 2004–2021. The conclusions were based on the trend-cycle component obtained by means of the X-13-ARIMA method. The analyses showed a negative relationship between the extent of the pandemic restrictions and the economic activity in banking, especially in the first phase of the crisis. Business tendency surveys show that during this crisis, the economic situation in the banking sector deteriorated more than during the financial crisis of 2008–2009. A relatively sharp decline as well as rapid rebounds were observed in the credit market, which caused its indicators to return in 2021 to the levels recorded before the outbreak of the pandemic. In the initial phase of the crisis, the economic downturn observed in the deposit market was not as sharp as in the credit market. On the other hand, however, the economic situation in the deposit market failed to improve significantly in 2021.
Influence of the COVID-19 pandemic on the mental health of society
Authors: Ptak-Chmielewska Aneta , Baszniak Karolina , Kurpanik Jarosław
Published: October 2022

The COVID-19 pandemic changed the lives of people all around the world, e.g. affected mental health and the functioning of several families. The main goal of the research presented in this paper is to assess the influence of the COVID-19 pandemic on the mental health of members of households. The research was performed on the basis of a data set from the COVID Impact Survey carried out by the Data Foundation think tank in 2020 (during the first wave of COVID-19 pandemic) in the USA among adult respondents. The survey used 6,768 observations. The authors estimated a model of logistic regression and models based on data mining methods, such as decision trees, XG Boost, k-nearest neighbours method, artificial neural networks and a support vector machine. Cluster analysis made it possible to divide respondents into groups showing their characteristic features and problems, and the constructed model took into account their mental issues and the relationship between those issues and the financial situation of households. The results demonstrate that isolation, remote education and work and limited physical activity contribute to the worsening of mental health of the population.
Satellite-based crop identification and area estimation under the SATMIROL system
Authors: Mleczko Magdalena , Slesiński Przemysław , Milewski Tomasz , Łączyński Artur , Miziołek Dariusz , Woźniak Edyta , Bojanowski Jędrzej
Published: October 2022

One important area where satellite-based Earth observation is applied in is agricultural statistics. The use of new digital technologies and satellite data have contributed to the modernisation of the aforementioned scientific area and is designed to overcome the problems that both agricultural statistics and the recipients of statistical data are faced with. The main aim of the article is to present an innovative system of satellite-based crop identification and crop growth monitoring – SATMIROL. The system was developed by Statistics Poland, the Institute of Geodesy and Cartography and the Space Research Centre of the Polish Academy of Sciences. SATMIROL provides agricultural statistics based on satellite data from the Copernicus programme and administrative data. The article focuses on selected modules of the system which involve the use of satellite remote sensing for crop identification. The study also presents a nationwide crop area estimation performed in three periods: 2019, 2020 and 2021. The implementation of SATMIROL allowed the presentation of statistical data on agriculture in spatial terms, which is not possible when applying traditional methods of data production. This new method of acquiring data enables their presentation at all levels of Poland’s administrative division, i.e. by voivodship, poviat (district) and gmina (commune).
ALTERAÇÕES EMOCIONAIS EM GESTANTES NO PERÍODO DE PANDEMIA DA COVID-19
Authors: FUCHS Giselle C. , SPINDOLA Ana P. , WOICHEKOSKI Jaqueline
Published: October 2022

Os potenciais efeitos da infecção materna e no feto por COVID-19 foram preocupações que atingiram toda a sociedade, essa incerteza se repetiu na psique das gestantes, gerando implicações no seu estado emocional. Então, somando as alterações emocionais da gestação mais o quadro da Pandemia de COVID-19, buscou-se investigar as alterações emocionais nas gestantes durante a pandemia da COVID-19 dos municípios de Mafra, Rio Negrinho e São Bento do Sul/ SC. Participaram 34 gestantes, através da Metodologia Snowball, com aplicação de questionário específico sobre o tema, do GAD-7 e do PHQ-9, aplicados pelo Google Formulários. Como resultados, foram encontrados que 17% das gestantes testaram positivo para COVID-19 e destas 80% já estavam grávidas quando positivaram e sentiram-se com medo e preocupadas com a notícia; 29% das gestantes apresentaram ansiedade leve e 29% apresentaram depressão leve. Para 35% das gestantes essas alterações permaneceram por mais de 6 meses. Percebeu-se então que as gestantes apresentaram medos quanto a contaminação por COVID-19, principalmente em relação à vida delas e do bebê. Estes receios mantiveram-se por quase toda a gestação e isto a longo prazo poderia resultar em dificuldades no parto, pós-parto, vinculação mãe-bebê e no desenvolvimento do bebê.
Online Teaching during Covid-19 Pandemic: Perspectives of Stakeholders
Authors: Mohanty Ajaya Kumar , Mishra Sudarshan
Published: October 2022

The present paper studied the experiences and problems confronted by students and teachers of higher education institutions of India for online teaching during Covid-19 pandemic. The researchers through online survey, and interviews collected the data. The students’ engagement was characterized by reading of digital study materials, asking questions for doubt clearing, reading of PPTs, noting down important points in the class and preparing class notes. The teachers’ engagement was characterized by preparation of class note and PPTs, asking questions to students for making the class interactive, sharing of reading materials, delivery of lecture on the content, clarifying students’ doubts and collection of assignment and feedback from students; and reflections for improving teaching. Both students and teachers preferred online classes and viewed that it is preferred for self-motivated students. Regarding its benefits, both teachers and student viewed that online teaching saves time in course coverage, improves their self-learning habits and exposed to wide variety of digital materials and collaborative technologies and have increased presentation, communication and interpersonal skills. Students are confronted with serious problems like, poor network connectivity, high rate of data consumption and physical discomforts. The prominent problems confronted by the teachers are poor students’ attendance, poor participation, missing liveliness of teaching and no pedagogical orientation on online teaching.
Inclusive ODL: Implications for the Adoption of Blended Instructional Learning Strategy in the 21st Century Technological Era
Authors: Salawu Ibrahim
Published: October 2022

The need for the paradigm shift in the practice of education with emphasis on exclusiveness to inclusiveness has been in the forefront of debate for quite a long time. While the practice of exclusiveness seems to be predominantly evidenced in the conventional system, the open and distance learning (ODL) system is exceptional. At both pedagogical and philosophical spheres, ODL adheres itself to the dictates of inclusive approach to educational practice. It is however one thing to peripherally satisfy inclusive education through ODL, but another thing in using pedagogical instructional strategies that should go along with the actualisation of an ideal inclusive education. For this reason, the paper examines the whole of the concept of inclusiveness and relating it to blended instructional strategy (BIS) as globally accepted delivery mode in ODL. It critically examines the BIS in a manner that suggests the need for a new global understanding more suitable to applicability to the concept of inclusiveness. Some specific variables like geographical location, job orientation, learners’ various and varied characteristics were examined as they relate to the new approach being suggested.
Supporting Institutions to Utilise Assistive Technology in ODL to Enhance Learning of Trainees with Disability in Low-Income Countries
Authors: Chambers Dianne , Okinda Robert
Published: October 2022

This paper presents information from a study of the use of Assistive Technology (AT) during open and distance learning (ODL) in TVET training institutions. There has been an increase in the number of people with disability enrolling into post-secondary education and, with the advent of COVID, learning has often moved to either a blended or online mode. There is also an increasing level of digitisation across the world, and a need for learners to be fluent in some of the digital technologies that are changing the nature of education and the workplace. Training for instructors is a key element of ensuring trainee success and inclusion when using AT in the learning environment. // Data were collected via a range of sources. A desktop review identified areas of appropriate literature. A survey was then developed and conducted with staff in TVET institutions which gathered data on competencies required by staff to engage learners and their experiences with AT and trainees with disability. This data resulted in the development of a course to support staff working with AT and trainees with disability in an open and distance mode. Development of the course is described along with its initial piloting and feedback from participants.
Educational Development in Africa: Bridging disability Gap with Distance Learning for the Visually Impaired
Authors: Egenti Grace , Ikeokwu Justin , Fadayomi Bayonle
Published: October 2022

It is a known fact that the era of the Covid19 pandemic has further exposed the concept and technology of distance learning as more and more people are now interested in higher education through the distance learning mode. Distance learning courses are possibly an appropriate tool for mainstream students with impairments in education since they rely significantly on digital material and are technology-mediated. However, in the drive to move forward, most structures/systems are typically created without taking into cognizance the unique interface issues those students with disabilities are confronted with while using technology, especially the blind and the visually impaired. Hence, this paper is aimed at creating an enabling examination platform where this vulnerable group would be supported by providing a voice supported application, ODL Visually Impaired Assessment Bot for the blind and the visually impaired to write their examinations. This will further ensure equality and inclusive education in acquiring life-long learning through distance learning. Artificial intelligence technologies were used to develop a Robot that was used for the implementation of the Application. The Robot reads out the examination questions to the blind and visually impaired student and also listens to the student speak and thereafter captures and types out the answers of the student. It is against this backdrop that this paper is written to proffer a solution to the blind and the visually impaired students in Africa, especially, the National Open University of Nigeria. The significance of this ODL Visually Impaired Assessment Bot is aimed at building a sustainable educational system through the use of technology, thus eradicating limiting ideologies in Africa, like ‘those with disabilities cannot be educated and the rich only deserve quality education’. This application will create a level ground for all to access life-long quality education, through the open and distance mode. The visually impaired if given proper education cannot constitute any form of liability but an asset to themselves, their families and the society at large.
Fostering Lifelong Learning through Recognition of Prior Learning as an Enabler of Increased Productivity, Improved Wood Product Quality and Employee Motivation- A Case Study of Kubu Crafts LTD in Zambia
Authors: Kabeya Vincent , Kasonkomona Phyllis Chibuye Lubeya
Published: October 2022

Recognition of Prior Learning (RPL) in Zambia has been used as a vehicle through which individual learners with significant experience in a given practical field earn a qualification at any level of education. RPL in this case is an enabler of an individual’s empowerment socially and economically. This type of empowerment leads to intrinsic motivation resulting in improved productivity and quality of products. Using a randomized control method, this case study seeks to establish the impact of RPL on productivity and quality of wood products at Kubu Crafts LTD. Six three (63) employees were enrolled in the RPL programme and monitored closely on how their acquired competencies yet to be formalized will lead to improved productivity and wood product furniture quality. Data will be analyzed both qualitatively and quantitatively. For secondary data collection Company’s Order Reports and Delivery Notes served as special instruments for secondary data collection while clients’ feedback through questionnaires and interviews formed a basis for primary data collection. Results indicated a production increase of 49% after RPL was introduced confirming the impact of RPL on production. A great improvement in the percentage of rejected furniture from 31.07% previously to 0.23% was noted signifying an improvement on quality of wood products after RPL. Attendance on a monthly basis improved from 17.46% of employees being absent before RPL introduction to only 4.76% after the introduction of RPL hence the environment became motivating. From the findings, the researcher concludes that lifelong learning should be fostered through RPL as an enabler of increased productivity, improved wood product quality and motivated employees.
Instructional Design for Quality Education: Role of A Digital Learning Hub
Authors: Kovilpillai Jonathan J S , Uzza Aisyamariam Abdul , Singh Abtar Darshan , Low Yvonne
Published: October 2022

Quality education forms the foundation of all educational institutions and is made up of many aspects; a clear, well-thought-out curriculum and instructional design (ID) process, and everything else supporting the curriculum and ID ideals such as learning spaces, well-trained educators, availability of resources, management of processes and monitoring & evaluation exercises. For a long time, design and development of curriculum and ID was treated as a “given”, either because the curriculum was designed by a central body or “ID” was just another “normal” process, which was part and parcel of an employed educator, especially in higher education institutions (HEI). With current changes in the educational landscape whereby there is no guarantee of how a learning segment will be conducted, it is imperative that HEI look at these two components with a wider lens to mitigate possible setbacks and glitches for sustainable and continuing quality education. It has become vital that upskilling of ID is quickly acquired and certified. Considering this, we present a case study of how the Digital Learning Hub at the Asia Pacific University of Technology and Innovation has designed, developed, and implemented various projects using rapid instructional design methods to leap-frog and enable educators to gain crucial training for the skills and competencies related to instructional design. The aspects discussed include an overview of the newly setup digital learning hub, the amoebic process of achieving quality education, with ID as a core anchor and circumvented by the smart inter-play of stakeholders: students, educators, support staff, and leaders.
Performative Act of the Subaltern: A Postcolonial Figure of Subaltern Resistance in Mahasweta Devi’s Draupadi
Authors: Aftab Ur Rahaman Zahin
Published: October 2022

This paper attempts to evaluate the resistance to the ethnic and gender subalternity portrayed by Mahasweta Devi n the story, Draupadi. Mahasweta Devi portrays a figure of resistance to the multi-layered subalternity through the rejection of gender performative acts in both theatrical and non-theatrical contexts of subaltern. The story, Draupadi, challenges the conventional phallocentric representation of gender subalterns and colonial domination over marginalized ethnicity through the construction of the character, Dopdi Mejhen (or Draupadi), a young Santal widow, fighting for the socioeconomic freedom of her tribe, who radically stands naked exposing her blood spotted body against the oppressive colonizer after extreme physical oppression, to protest the patriarchal and colonial domination over her body and ethnic community. She is subaltern by her class, caste and gender; but liberates herself from subalternity through non-cooperation resistance. This paper applies the theory of ‘subalternity’ of Ranajit Guha and Chakravorty Spivak to bring out the aspects of multi-layered subalternity and intellectual location of the resistance, and theory of ‘gender performativity’ of Judith Butler to evaluate the resistance of gender subalternity. This research proves that the conquering resistance to the colonial domination and subalternity is the result of the non-cooperative movement against dominant elitism, rejection of gender performative acts in both theatrical and nontheatrical contexts, radical stand against ethnic representation, existential tactic to disrupt the essential codes and dominant administrative colonial power.