bluuebunny/crossref_metadata_2025 huggingface dataset:
Riccati–Bernoulli sub-ode method-based exact solution of new coupled Konno–Oono equation
Authors: Sahoo Mrutyunjaya , Chakraverty S.
Published: April 2024

Nonlinear partial differential equations (NLPDEs) have emerged as a major focus of study in a variety of nonlinear science disciplines. This is because in general, mathematical, physics and engineering problems may be stated by NLPDEs. It may be noted that a specific kind of exact/analytical solution called traveling wave solutions for NLPDEs has great significance. In this regard, this paper addresses the traveling wave solution to the new coupled Konno–Oono equation (NCKOE), a set of NLPDE. A traveling wave transformation and the Riccati–Bernoulli sub-ode method (RBSOM) are used here to retrieve the exact/analytical traveling wave solution of the NCKOE. By using the above-mentioned approach, NLPDEs can be updated toward a collection of algebraic equations. Further, different types of solitary wave solitons, Trigonometric function solutions, Hyperbolic soliton solutions and dark bright solitons to the NCKOE have been successfully retrieved. Importantly, the newly derived solutions adhere to the main equation when they are inserted into the governing equations. Furthermore, through an appropriate selection of parameters, three-dimensional and two-dimensional figures are presented for physical illustration of the obtained solutions. These visual representations serve to showcase the effectiveness, conciseness and efficiency of the applied techniques.
Index Shipping for Efficient Replication in LSM Key-Value Stores with Hybrid KV Placement
Authors: Stylianakis Giorgos , Saloustros Giorgos , Chiotakis Orestis , Xanthakis Giorgos , Bilas Angelos
Published: April 2024

Key-value (KV) stores based on the LSM tree have become a foundational layer in the storage stack of datacenters and cloud services. Current approaches for achieving reliability and availability favor reducing network traffic and send to replicas only new KV pairs. As a result, they perform costly compactions to reorganize data in both the primary and backup nodes, which increases device I/O traffic and CPU overhead, and eventually hurts overall system performance. In this article, we describe 
Tebis
, an efficient LSM-based KV store that reduces I/O amplification and CPU overhead for maintaining the replica index. We use a primary-backup replication scheme that performs compactions only on the primary nodes and sends pre-built indexes to backup nodes, avoiding all compactions in backup nodes. Our approach includes an efficient mechanism to deal with pointer translation across nodes in the pre-built region index. Our results show that
Tebis
reduces resource utilization on backup nodes compared to performing full compactions: throughput is increased by 1.06 to 2.90×, CPU efficiency is increased by 1.21 to 2.78×, and I/O amplification is reduced by 1.7 to 3.27×, whereas network traffic increases by up to 1.32 to 3.76x.
A Three-Dimensional AgNPs/TiO2/Ti3C2Tx Composite for Label-Free Thrombin Aptamer Sensor
Authors: Li Chunguang , Zou Huiyan , Zhang Feifei , Wang Zonghua
Published: April 2024

A one-step hydrothermal method was employed to synthesize a three-dimensional (3D) AgNPs/TiO2/Ti3C2Tx composite. Hydrothermal conditions were used to promote the growth of TiO2 nanorods on the Ti3C2Tx sheet, resulting in the formation of a three-dimensional composite nanomaterial. Glutamic acid served as both a reducing agent and a stabilizer to load Ag nanoparticles (AgNPs) onto the 3D composite nanomaterial. The structure of the composite material provided a large accessible surface area, facilitating the anchoring of Ag NPs. Thrombin aptamers were then linked to Ag NPs through Ag-S bonds, establishing a sensitive and label-free aptasensor for thrombin detection. The proposed aptasensor demonstrated excellent electrochemical performance, with a broad linearity range of 5.0 fM to 500 nM and a relatively low detection limit of 2.0 fM (S/N = 3). These findings indicate the potential of Ag NPs/TiO2/Ti3C2Tx in the development of promising electrochemical biosensors.
Communication—Improving Corrosion Resistance of Lead-Alloy Positive Grid of Lead-Acid Battery by an Electrochemical Prepassivation Interphase
Authors: Ouyang Yu , Zhang Yiting , Han Lianhuan , Xiong Jianwen , Shi Jie , Zhan Dongping
Published: April 2024

Lead-acid battery (LAB) has a huge world market in both energy storage and power supply. However, most LAB failures are caused by the serious corrosion of positive grids. To this, we propose an electrochemical prepassivation strategy to form a compact interphase on the lead-alloy grid surface composed of lead oxides and lead sulfate, exactly the same as lead paste. The results show that the corrosion resistance of pre-passivated lead alloy is improved due to the inhibition of vertical growth of corrosion layer, providing a feasible solution to prolong the service life of LAB.
Oxygen Permeation Measurement of LaCrO3-based Interconnect Embedded in Real SOFCs
Authors: Yamaguchi Takuya , Ishiyama Tomohiro , Yamaji Katsuhiko
Published: April 2024

A method for evaluating the oxygen permeation flux through LaCrO3-based interconnects embedded in real solid oxide fuel cells (SOFCs) is proposed. The interconnect of the cell was placed in a two-chamber setup (fuel | interconnect | air), and the oxygen permeation flux was successfully determined by quantifying the amount of water vapor generated at the fuel side due to the permeation of oxygen from the air side to the fuel side. Using the proposed method, the oxygen permeation fluxes through the interconnects of the cells before and after 20,000 h of continuous operation were compared to examine the long-term stability of the LaCrO3-based interconnects. No significant difference was observed in the oxygen permeation flux before and after continuous operation, indicating that the LaCrO3-based interconnects have excellent chemical and thermal stability. In addition, the effect of oxygen permeation on energy conversion efficiency was investigated by calculating the Nernst loss. The calculations showed that oxygen permeation has almost no effect on the energy conversion efficiency.
ARJUNA: An Electrochemical Interface Mapping Probe for Solid-State Batteries
Authors: Dixit Marm , Kwok Chen Yuen , Amin Ruhul , Polizos Georgios , Balasubramanian Mahalingam , Belharouak Ilias
Published: April 2024

Solid-state batteries (SSBs) are promising candidates for next-generation energy storage, although their performance can be compromised by interfacial heterogeneity within the electrolyte. Furthermore, ensuring the quality of large form-factors electrolyte film is crucial for establishing a robust manufacturing platform for solid-state batteries. Herein, we report on the use of ARJUNA, an electrochemical interface mapping system, to characterize heterogeneities at solid electrolyte interfaces and to serve as a quality control system for SSB manufacturing. In addition to spatial mapping, the proposed system can also probe the interface behavior as a function of pressure and temperature. We present the operating principle, design, instrumentation, and evaluation of the system alongside a typical hybrid solid electrolyte produced using two common manufacturing processes. This report showcases the capability of ARJUNA to probe the heterogeneity and quality of processed solid electrolyte films.
Lithium-Gold Electrochemical Alloying: Clarifying Reaction Pathways and Products Using Operando XRD
Authors: Hejazi Sina , Liang Ruilin , Sergeenko Ania , Fleischauer Michael D.
Published: April 2024

Gold electrodes are used in lithium-ion battery research despite their high cost and unclear reactivity with lithium. Many equilibrium phases of gold-lithium (Au-Li) exist—solid solutions alpha, beta, and delta, and intermetallic phases AuLi3 and Au4Li15. During the first alloying reaction, the equilibrium alpha and beta phases are seemingly bypassed; a phase, presumably delta, forms at a potential of 0.25 V (all potentials vs Li/Li+), followed by the formation of AuLi3 at 0.15 V at all conditions tested and Au4Li15 at 0.05 V in select conditions. Alloying reactions are reversible to (delta), followed by the formation of another phase near 0.3 V and a low Li content phase at potentials above 0.4 V during de-alloying. Observed diffraction peaks only partially align with previous reports for all phases other than Au4Li15. The second alloying/de-alloying cycle is reversible between a low Li content phase (not pure gold) and the terminal phase. Some reaction hysteresis is present at low Li content. While the (delta)/AuLi3 reaction had a consistent potential during alloying and de-alloying, the potential otherwise varied strongly with temperature, rate, and composition, implying that gold quasi-reference electrodes may not be suitable for lithium-ion battery research.
Exhaustive Study of Electrical Conductivity in the MNb2−x
TixO6–0.5x
(M = Mg, Ca, Zn; x = 0, 0.1, 0.2) Columbites
Authors: Morkhova Yelizaveta A. , Koroleva Mariia S. , Egorova Anastasia V. , Krasnov Aleksei G. , Starostina Inna A. , Kabanov Artem A.
Published: April 2024

The CaNb2O6 and ZnNb2O6 columbites (Sp.gr. Pbcn) were studied as oxygen ion conductors both theoretically and experimentally. A theoretical approach included geometrical-topological analysis, bond valence site energy (BVSE) and density functional theory (DFT) calculations. The BVSE approach showed the possibility of pure oxygen ions diffusion with migration energies less than 0.45 eV in both compounds. However, DFT calculations indicated the possibility of diffusion of both anions and cations. The single-phases columbites were synthesized by the Pechini method for accurately determine charge carriers type and investigated by impedance spectroscopy, by the Tubandt method, which confirmed the absence of cationic conductivity, and measured the electrical conductivity as a function of oxygen partial pressures. The CaNb2O6 sample was characterized by the pure oxygen-ionic conductivity ∼2 × 10−6 S cm–1 at 800 °C (E

a
= 0.82 eV), while the ZnNb2O6 had a similar conductivity value due to mixed ionic-electronic contribution (E

a
= 0.83 eV). The electromotive force method also showed the predominance of the ionic type of conductivity in CaNb2O6, while ZnNb2O6 has a mixed conductivity with ion transport number of about 0.4. Additionally, we synthesized Ti-doped samples MNb2−x
Ti
x
O6–0.5x
(M = Mg, Ca; x = 0.1, 0.2) to study the doping effect on conducting properties.
Patients with autoimmune liver disease have glucose disturbances that mechanistically differ from steatotic liver disease
Authors: Jensen Anne-Sofie H. , Ytting Henriette , Werge Mikkel P. , Rashu Elias B. , Hetland Liv E. , Thing Mira , Nabilou Puria , Burisch Johan , Bojsen-Møller Kirstine N. , Junker Anders E. , Hobolth Lise , Mortensen Christian , Tofteng Flemming , Bendtsen Flemming , Møller Søren , Vyberg Mogens , Serizawa Reza R. , Gluud Lise L. , Wewer Albrechtsen Nicolai J.
Published: April 2024

Patients with autoimmune liver disease but without overt diabetes display glucose disturbances early on in their disease course. We identified pathophysiological traits specific to these patients including altered incretin responses.
Biomechanical increase in cervical esophageal wall tension during peristalsis
Authors: Lang Ivan M. , Medda Bidyut K. , Shaker Reza
Published: April 2024

Circumferential tension of cervical esophagus (CTE) increases during esophageal peristalsis. CTE response is correlated with distal longitudinal tension on cervical esophagus during esophageal peristalsis but not laryngeal elevation or esophageal muscle contraction. CTE response is not blocked by transection of motor innervation of laryngeal elevating muscles or proximal esophagus but is temporally reduced after hexamethonium administration. We conclude that the CTE response is a biomechanical effect caused by longitudinal esophageal contraction during esophageal peristalsis.
Revisiting airway epithelial dysfunction and mechanisms in chronic obstructive pulmonary disease: the role of mitochondrial damage
Authors: He Qinglan , Li Peijun , Han Lihua , Yang Chen , Jiang Meiling , Wang Yingqi , Han Xiaoyu , Cao Yuanyuan , Liu Xiaodan , Wu Weibing
Published: April 2024

Chronic exposure to environmental hazards causes airway epithelial dysfunction, primarily impaired physical barriers, immune dysfunction, and repair or regeneration. Impairment of airway epithelial function subsequently leads to exaggerated airway inflammation and remodeling, the main features of chronic obstructive pulmonary disease (COPD). Mitochondrial damage has been identified as one of the mechanisms of airway abnormalities in COPD, which is closely related to airway inflammation and airflow limitation. In this review, we evaluate updated evidence for airway epithelial mitochondrial damage in COPD and focus on the role of mitochondrial damage in airway epithelial dysfunction. In addition, the possible mechanism of airway epithelial dysfunction mediated by mitochondrial damage is discussed in detail, and recent strategies related to airway epithelial-targeted mitochondrial therapy are summarized. Results have shown that dysregulation of mitochondrial quality and oxidative stress may lead to airway epithelial dysfunction in COPD. This may result from mitochondrial damage as a central organelle mediating abnormalities in cellular metabolism. Mitochondrial damage mediates procellular senescence effects due to mitochondrial reactive oxygen species, which effectively exacerbate different types of programmed cell death, participate in lipid metabolism abnormalities, and ultimately promote airway epithelial dysfunction and trigger COPD airway abnormalities. These can be prevented by targeting mitochondrial damage factors and mitochondrial transfer. Thus, because mitochondrial damage is involved in COPD progression as a central factor of homeostatic imbalance in airway epithelial cells, it may be a novel target for therapeutic intervention to restore airway epithelial integrity and function in COPD.
Leveraging Pretrained Language Models for Enhanced Entity Matching: A Comprehensive Study of Fine-Tuning and Prompt Learning Paradigms
Authors: Wang Yu , Zhou Luyao , Wang Yuan , Peng Zhenwan
Published: April 2024

Pretrained Language Models (PLMs) acquire rich prior semantic knowledge during the pretraining phase and utilize it to enhance downstream Natural Language Processing (NLP) tasks. Entity Matching (EM), a fundamental NLP task, aims to determine whether two entity records from different knowledge bases refer to the same real-world entity. This study, for the first time, explores the potential of using a PLM to boost the EM task through two transfer learning techniques, namely, fine-tuning and prompt learning. Our work also represents the first application of the soft prompt in an EM task. Experimental results across eleven EM datasets show that the soft prompt consistently outperforms other methods in terms of F1 scores across all datasets. Additionally, this study also investigates the capability of prompt learning in few-shot learning and observes that the hard prompt achieves the highest F1 scores in both zero-shot and one-shot context. These findings underscore the effectiveness of prompt learning paradigms in tackling challenging EM tasks.
A Concept of Online Refueling TRISO‐Fueled and Salt‐Cooled Reactor
Authors: Feng Xiaoyong , Lee Hyun Chul
Published: April 2024

This paper introduces a novel concept of a TRISO‐fueled salt‐cooled reactor (TFSCR). The core contains circulating pipes filled with molten salt carrying TRISO particles. The reactor achieves online refueling by slowly circulating the molten salt through the pipeline. The reactor utilizes the same molten salt as the coolant and graphite as the moderator. The reactor design has the characteristics of safety, economy, and nonproliferation. TRISO particles exhibit greater resistance to neutron irradiation, corrosion, oxidation, and high temperatures compared to conventional fuels. A molten salt‐cooled reactor can also operate at higher temperatures, consequently enhancing power generation efficiency. Furthermore, lower operating pressures can mitigate the risk of significant damages and loss of coolant caused by accidents, thereby enhancing reactor safety. This paper presents the basic nuclear design of TFSCR under the assumptions concerning the average fuel power density, the volumetric core power density, and the core temperature. At the same time, the feasibility of online refueling and long‐life operation was evaluated by fuel burnup calculation.
DLLog: An Online Log Parsing Approach for Large-Scale System
Authors: Cheng Hailong , Ying Shi , Duan Xiaoyu , Yuan Wanli
Published: April 2024

Syslog is a critical data source for analyzing system problems. Converting unstructured log entries into structured log data is necessary for effective log analysis. However, existing log parsing methods demonstrate promising accuracy on limited datasets, but their generalizability and precision are uncertain when applied to diverse log data. Enhancements in these areas are necessary. This paper proposes an online log parsing method called DLLog, which is based on deep learning and has the longest common subsequence. DLLog utilizes the GRU neural network to mine template words and applies the longest common subsequence to parse log entries in real-time. In the offline stage, DLLog combines multiple log features to accurately extract the template words, creating a log template set to assist online log parsing. In the online stage, DLLog parses log entries by calculating the matching degree between the real-time log entry and the log template in the log template set. This method also supports the incremental update of the log template set to handle new log entries generated by systems. We summarized the previous works and validated DLLog using real log data collected from 16 systems. The results demonstrate that DLLog achieves high parsing accuracy, universality, and adaptability.
Scalability of Generalized Frames for Operators
Authors: Kumar Varinder , Malhotra Sapna , Khanna Nikhil
Published: April 2024

In this paper, the Parseval K-g-frames are constructed from a given K-g-frame by scaling the elements of the K-g-frame with the help of diagonal operators, and these frames are named scalable K-g-frames. Also, we prove some properties of scalable K-g-frames and construct new scalable K-g-frames from a given K-g-frame. The necessary and sufficient conditions for a K-g-frame to be scalable are given. Further, equivalent conditions for the scalability of K-g-frames and the K-frames induced by K-g-frames are obtained. Finally, it is shown that the direct sum of two scalable K-g-frames is again a scalable K-g-frame for some suitable bounded linear operator K.
Table S6 from Proteasome Inhibition Reprograms Chromatin Landscape in Breast Cancer
Authors: Kinyamu H. Karimi , Bennett Brian D. , Ward James M. , Archer Trevor K.
Published: April 2024

Genomic coordinates of super enhancer regions per each cluster and nearby genes associated with basal and non-basal breast cancer subtypes, relating to Figure 5.
De Novo Purine Metabolism is a Metabolic Vulnerability of Cancers with Low p16 Expression
Authors: Tangudu Naveen Kumar , Buj Raquel , Wang Hui , Wang Jiefei , Cole Aidan R. , Uboveja Apoorva , Fang Richard , Amalric Amandine , Yang Baixue , Chatoff Adam , Crispim Claudia V. , Sajjakulnukit Peter , Lyons Maureen A. , Cooper Kristine , Hempel Nadine , Lyssiotis Costas A. , Chandran Uma R. , Snyder Nathaniel W. , Aird Katherine M.
Published: April 2024

p16 is a tumor suppressor encoded by the CDKN2A gene whose expression is lost in approximately 50% of all human cancers. In its canonical role, p16 inhibits the G1–S-phase cell cycle progression through suppression of cyclin-dependent kinases. Interestingly, p16 also has roles in metabolic reprogramming, and we previously published that loss of p16 promotes nucleotide synthesis via the pentose phosphate pathway. However, the broader impact of p16/CDKN2A loss on other nucleotide metabolic pathways and potential therapeutic targets remains unexplored. Using CRISPR knockout libraries in isogenic human and mouse melanoma cell lines, we determined several nucleotide metabolism genes essential for the survival of cells with loss of p16/CDKN2A. Consistently, many of these genes are upregulated in melanoma cells with p16 knockdown or endogenously low CDKN2A expression. We determined that cells with low p16/CDKN2A expression are sensitive to multiple inhibitors of de novo purine synthesis, including antifolates. Finally, tumors with p16 knockdown were more sensitive to the antifolate methotrexate in vivo than control tumors. Together, our data provide evidence to reevaluate the utility of these drugs in patients with p16/CDKN2Alow tumors as loss of p16/CDKN2A may provide a therapeutic window for these agents.

Significance:

Antimetabolites were the first chemotherapies, yet many have failed in the clinic due to toxicity and poor patient selection. Our data suggest that p16 loss provides a therapeutic window to kill cancer cells with widely-used antifolates with relatively little toxicity.
Development of an Algorithm for Correct Placement of the Basal Electrode Contact in the Context of Anatomy-Based Cochlear Implantation: A Proof of Concept
Authors: Spahn Bjoern , Voelker Johannes , Müller-Graff Franz-Tassilo , Engert Jonas , Bauer Daniel , Kurz Anja , Hagen Rudolf , Neun Tilmann , Zabler Simon , Rak Kristen
Published: April 2024

Background: Correct individual tonotopic frequency stimulation of the cochlea plays an important role in the further development of anatomy-based cochlear implantation. In this context, frequency-specific fitting of the basal electrode contact with a normal insertion depth can be difficult since it is often placed in a frequency range higher than 10 kHz, and current audio processors only stimulate for frequencies up to 8.5 kHz due to microphone characteristics. This results in a mismatch of the high frequencies. Therefore, this study represents a proof of concept for a tonotopic correct insertion and aims to develop an algorithm for a placement of the basal electrode below 8.5 kHz in an experimental setting. Methods: Pre- and postoperative flat-panel volume CT scans with secondary reconstructions were performed on 10 human temporal bone specimens. The desired frequency location for the most basal electrode contact was set at 8.25 kHz. The distance from the round window to the position where the basal electrode contact was intended to be located was calculated preoperatively using 3D-curved multiplanar reconstruction and a newly developed mathematical approach. A specially designed cochlear implant electrode array with customized markers imprinted on the silicone of the electrode array was inserted in all specimens based on the individually calculated insertion depths. All postoperative measurements were additionally validated using otological planning software. Results: Positioning of the basal electrode contact was reached with only a small mean deviation of 37 ± 399 Hz and 0.06 ± 0.37 mm from the planned frequency of 8.25 kHz. The mean rotation angle up to the basal electrode contact was 51 ± 5°. In addition, the inserted electrode array adequately covered the apical regions of the cochleae. Conclusion: Using this algorithm, it was possible to position the basal electrode array contact in an area of the cochlea that could be correctly stimulated by the existing speech processors in the context of tonotopic correct fitting.
Transcatheter Closure of Atrial Septal Defects with Absent Aortic Rim and the Predictors of Right Atrial Reverse Remodeling: 5 Years Experience in China
Authors: Li Mingfei , Lin Dawei , Fan Jianing , Zhang Feng , Pan Wenzhi , Zhou Daxin , Ge Junbo
Published: April 2024

Introduction: Atrial septal defect (ASD) is one of the most common congenital heart malformations. Although not recommended, a significant proportion of patients with aortic root defects receive ASD closure, some of whom have improved right ventricular function. The study aimed to investigate the safety of interventional therapy in ASD patients with complete aortic rim deficiency and explore the predictors of right atrial (RA) non-reverse remodeling. Methods: 1,011 patients with ASD who underwent transcatheter closure in the Department of Cardiology, Zhongshan Hospital, affiliated to Fudan University from June 2017 to June 2023 were enrolled in the study. They were divided into a complete aortic rim deficiency group and without absent aortic rim group. Furthermore, patients who had an enlarged RA in the absent aortic rim group were divided into two subgroups according to whether their RA remodeling was reversed post-procedure. Multivariate logistic regression was used to determine the predictors of RA reverse remodeling. Results: During the 1-year follow-up, no major operative complications occurred in all patients with the absence of an aortic rim and a normal edge. After the operation, the right heart remodeling was significantly reversed, multivariate logistic regression analysis was performed, and it was found that no coronary heart disease before an operation, lower plasma creatinine level, and larger RA and RV dimensions were the predictive factors for the reverse of RA remodeling after treatment. Conclusion: Transcatheter closure of ASD with complete aortic rim deficiency is safe and feasible. For patients without coronary heart disease, the lower the creatinine value and the lower the tricuspid regurgitation before an operation, the more improvement of RA remodeling after the operation.
Detection mecA gene and Staphylococcus aureus resistance to several antibiotics isolated from cat ear swabs at a veterinary hospital located at Surabaya – Indonesia
Authors: Kaben Sergius Erikson , Al-Arif Mohammad Anam , Ma’ruf Anwar , Effendi Mustofa Helmi , Kurniawan Shendy Canadya , Riwu Katty Hendriana Priscilia , Afnani Daniah Ashri , Silaen Otto Sahat Martua , Millannia Saumi Kirey , Ramadhani Safira , Widodo Agus , Farizqi Thoriq Ihza , Khairullah Aswin Rafif
Published: April 2024

Gatos são suscetíveis a adquirir S.aureus que colonizam principalmente as narinas e os ouvidos de espécies de felinos. A otite externa no ouvido dos gatos é uma das doenças produzidas pelo S.aureus nos animais. A terapia com antibióticos é o tratamento convencional para as infecções produzidas pelo S.aureus. Os antibióticos utilizados durante o prolongado tratamento e o emprego de sub doses podem selecionar microorganismos resistentes. Com base em tais argumentos torna-se necessária a pesquisa de S.aureus isolados do ouvido dos gatos, bem como, a realização de testes para a resistência a antibióticos e do gene mecA. Empregando swabs estéreis de algodão foram obtidas amostras dos ouvidos dos gatos em meio de Amies. O isolamento bacteriano foi efetuado em meio MAS e os testes catalase e coagulase foram realizados para a identificação das bactérias. A sensibilidade dos isolados de S.aureus foi avaliada com o emprego de discos dos antibióticos cefoxitin, tetraxiclina, eritromicina, gentamicina e cloranfenicol, incorporados no meio MHA. Todos os isolados positivos de S.aureus foram submetidos ao test MRSA para a detecção do gene mecA. A amostra investigada revelou 91% (91/100) de positivos para S.aureus, dos quais, 3,30% (3/91) foram resistentes a múltiplas drogas (MDR) pois foram resistentes a 3-4 classes de antibióticos. De 12 MRSA isolados analisados o gene mecA foi detectado em um isolado. O uso inapropriado de antibióticos é a causa da resistência bacteriana em pets. Adicionalmente o emprego excessivo de antibióticos em uma população pode resultar no desenvolvimento de resistência bacteriana adquirida a antibióticos. O uso de antibióticos em animais deve ser ordenado por uma administração de medicamentos apropriada para prevenir o desenvolvimento da resistência.
Caracterização e restauração estrutural de uma área do Pré-sal da Bacia de Santos e o impacto da paleogeografia no controle da deposição das fácies no reservatório
Authors: Carvalho Renato Kramberger , Mello Claudio Limeira , Souza Junior Olinto Gomes de
Published: April 2024

O forte controle estrutural exercido sobre a deposição dos carbonatos da Formação Barra Velha (Aptiano), Pré-sal da Bacia de Santos, durante as fases rifte e sag condicionou os processos estratigráficos e sedimentológicos que controlaram a distribuição e a qualidade desses reservatórios. O entendimento de como e com que intensidade a evolução estrutural impactou a distribuição das fácies carbonáticas é crucial para se fazer um mapeamento preditivo dos reservatórios. O presente estudo foi desenvolvido na área de Iracema, campo de Tupi, onde foram mapeados cinco horizontes sísmicos e 74 falhas objetivando a caracterização e restauração estrutural e a reconstrução da paleogeografia dos reservatórios à época da deposição da Formação Barra Velha, se restringindo ao intervalo depositado durante a fase sag da bacia. Foi construída uma superfície de paleobatimetria para os horizontes restaurados referentes aos limites basais dos intervalos sag inferior e sag superior, considerando as profundidades de deposição dos carbonatos com base em depósitos análogos recentes, de acordo com estudos anteriores realizados na própria bacia. Para exemplificar a aplicação da análise paleobatimétrica realizada, foi conduzida uma modelagem de processos estratigráficos e sedimentológicos no intervalo superior da fase sag, permitindo reproduzir cenários da arquitetura interna da plataforma carbonática. Os resultados demonstram que a restauração realizada apresenta uma melhor e preditiva caracterização faciológica do reservatório, que irá orientar a definição da distribuição de porosidade e permeabilidade em trabalhos de caracterização 3D do reservatório.
Manifestations of Prosthetic Valve Endocarditis: Lessons From Multimodality Imaging and Pathological Correlation
Authors: Hutt Erika , Canosa Francisco Jesus Marco , Unai Shinya , Jaber Wael A.
Published: April 2024

Heart valve replacement has steadily increased over the past decades due to improved surgical mortality, an aging population, and the increasing use of transcatheter valve technology. With these developments, prosthetic valve complications, including prosthetic valve endocarditis, are increasingly encountered. In this review, we aim to characterize the manifestations of prosthetic valve endocarditis using representative case studies from our institution to highlight the advances and contributions of modern multimodality imaging techniques.
Systolic Blood Pressure and Survival to Very Old Age: Results From the Women’s Health Initiative
Authors: Haring Bernhard , Andrews Chris A. , Hovey Kathleen , Shadyab Aladdin H. , LaCroix Andrea , Martin Lisa Warsinger , Rosal Milagros C. , Kuller Lewis H. , Salmoirago-Blotcher Elena , Saquib Nazmus , Koo Patrick , Laddu Deepika , Stefanick Marcia L. , Manson JoAnn E. , Wassertheil-Smoller Sylvia , LaMonte Michael J.
Published: April 2024

BACKGROUND:

The relationship between systolic blood pressure (SBP) and longevity is not fully understood. We aimed to determine which SBP levels in women ≥65 years of age with or without blood pressure medication were associated with the highest probability of surviving to 90 years of age.

METHODS:

The study population consisted of 16 570 participants enrolled in the Women’s Health Initiative who were eligible to survive to 90 years of age by February 28, 2020, without a history of cardiovascular disease, diabetes, or cancer. Blood pressure was measured at baseline (1993 through 1998) and then annually through 2005. The outcome was defined as survival to 90 years of age with follow-up. Absolute probabilities of surviving to 90 years of age were estimated for all combinations of SBP and age using generalized additive logistic regression modeling. The SBP that maximized survival was estimated for each age, and a 95% CI was generated.

RESULTS:

During a median follow-up of 19.8 years, 9723 of 16 570 women (59%) survived to 90 years of age. Women with an SBP between 110 and 130 mm Hg at attained ages of 65, 70, 75, and 80 years had a 38% (95% CI, 34%–48%), 54% (52%–56%), 66% (64%–67%), or 75% (73%–78%) absolute probability to survive to 90 years of age, respectively. The probability of surviving to 90 years of age was lower for greater SBP levels. Women at the attained age of 80 years with 0%, 20%, 40%, 60%, 80%, or 100% time in therapeutic range (defined as an SBP between 110 and 130 mm Hg) had a 66% (64%–69%), 68% (67%–70%), 71% (69%–72%), 73% (71%–74%), 75% (72%–77%), or 77% (74%–79%) absolute survival probability to 90 years of age.

CONCLUSIONS:

For women >65 years of age with low cardiovascular disease and other chronic disease risk, an SBP level <130 mm Hg was found to be associated with longevity. These findings reinforce current guidelines targeting an SBP target <130 mm Hg in older women.
The Role of Uniform Textures in Making Texture Elements Visible in
the Visual Periphery
Authors: Bertamini Marco , Oletto Carolina Maria , Contemori Giulio
Published: April 2024

There are important differences between central and peripheral vision. With respect to shape, contours retain phenomenal sharpness, although some contours disappear if they are near other contours. This leads to some uniform textures to appear non-uniform (Honeycomb illusion, Bertamini et al., 2016). Unlike other phenomena of shape perception in the periphery, this illusion is showing how continuity of the texture does not contribute to phenomenal continuity. We systematically varied the relationship between central and peripheral regions, and we collected subjective reports (how far can one see lines) as well as judgments of line orientation. We used extended textures created with a square grid and some additional lines that are invisible when they are located at the corners of the grid, or visible when they are separated from the grid (control condition). With respects to subjective reports, we compared the region of visibility for cases in which the texture was uniform (Exp 1a), or when in a central region the lines were different (Exp 1b). There were no differences, showing no role of objective uniformity on visibility. Next, in addition to the region of visibility we measured sensitivity using a forced-choice task (line tilted left or right) (Exp 2). The drop in sensitivity with eccentricity matched the size of the region in which lines were perceived in the illusion condition, but not in the control condition. When participants were offered a choice to report of the lines were present or absent (Exp 3) they confirmed that they did not see them in the illusion condition, but saw them in the control condition. We conclude that mechanisms that control perception of contours operate differently in the periphery, and override prior expectations, including that of uniformity. Conversely, when elements are detected in the periphery, we assign to them properties based on information from central vision, but these shapes cannot be identified correctly when the task requires such discrimination.
The Formal and Real Subsumption of Gender Relations
Authors: Portella Elizabeth , Busk Larry Alan
Published: April 2024

Attempts to unify Marxist and feminist social critique have been vexed by the fact that ‘patriarchy’ predates the advent of capitalism (its transhistorical status). Feminists within the Marxist, socialist, and materialist traditions have responded to this point by either granting patriarchy a certain autonomy relative to capitalism (the ‘dual/triple systems’ approach), or by suggesting that patriarchal relations have a foundational and necessary status in the history of capitalist development (which we term the ‘origins-subsistence’ approach). This paper offers an alternative account of the relationship between capitalism and the transhistorical status of ‘patriarchy’. In aid of a ‘unitary theory’ of Marxist Feminism, we argue that the transhistorical status of patriarchy is better understood through an application of Marx’s concepts of formal and real subsumption. A modified version of these concepts can illuminate not only capitalist appropriation of antecedent social and economic forms, but also its capacity to produce new forms of gendered exploitation and oppression.
Morphology and multigene phylogeny reveal a novel Stagonospora species (Massarinaceae, Dothideomycetes) from Thailand
Authors: BHAGYA AMUHENAGE T. , PHUKHAMSAKDA CHAYANARD , TANAKA KAZUAKI , JONES E.B. GARETH
Published: April 2024

Stagonospora is an asexual morph genus that is classified under Massarinaceae in Dothideomycetes. Stagonospora species have been recorded in both tropical and temperate regions. Several species have been reported as saprobic or opportunistic pathogenic lifestyles on grasses and grass-like plants. In this study, Stagonospora was collected from a Typha species in Sam Roi Yot wetland in central Thailand. Morphological examination was coupled with multi-loci phylogenetic analyses using maximum likelihood and Bayesian interference of a data set containing large subunit ribosomal rDNA (LSU rDNA), internal transcribed spacer (ITS) regions, small subunit ribosomal rDNA (SSU rDNA), and translation elongation factor 1-alpha (tef1-α) sequences. Our new taxon is distinguishable from other Stagonospora species by having hyaline, one-septate conidia that taper toward the base. This discovery holds significant value in comprehending the fungal diversity within Thailand’s wetlands and the specific fungal communities linked to Typha plants.
Słownik prasłowiański. Zintegrowany wykaz skrótów do tomów I–VIII, X, XI
Authors: Jakubowicz Mariola , Pogwizd Szymon
Published: April 2024

Słownik prasłowiański [Proto-Slavic Dictionary] is a work which combines features of an etymological dictionary and a study on the comparative history of the Slavic languages. The aim of its authors, who based on source materials from all Slavic languages, is to reconstruct the full lexical resource of the language used by the Slavic peoples immediately before the disintegration of the Proto-Slavic language community into individual languages (c. 7th–8th century AD). The first eight volumes were prepared under the auspices of the Linguistics Committee of the Polish Academy of Sciences at the Institute of Slavic Studies, Polish Academy of Sciences. They were published in 1974–2001 by the Ossolineum publishing house in a print version (the electronic version is available in the RCIN repository at https://rcin.org.pl/dlibra/publication/6907). Their editor was Franciszek Sławski. After a long break, the Institute of Slavic Studies published Volume 11 of the Dictionary, which contains a part of entries beginning with the letter K: Kǫ–Ky. It was prepared at the Kraków centre of the Institute by a team led by Mariola Jakubowicz (https://hdl.handle.net/20.500.12528/1975). Zintegrowany wykaz skrótów do tomów I–VIII, X, XI [Integrated List of Abbreviations for Volumes 1–8, 10, 11] is an electronic appendix (in pdf format) listing all source abbreviations used in the volumes of Słownik prasłowiański published so far (vol. 1–8, 10–11).
Investigating Temporal Characteristics of Polarimetric and Electrical Signatures in Three Severe Storms: Insights from the VORTEX-Southeast Field Campaign
Authors: Sharma Milind , Tanamachi Robin L. , Bruning Eric C.
Published: April 2024

The dual-polarization radar characteristics of severe storms are commonly used as indicators to estimate the size and intensity of deep convective updrafts. In this study, we track rapid fluctuations in updraft intensity and size by objectively identifying polarimetric fingerprints such as ZDR and KDP columns, which serve as proxies for mixed-phase updraft strength. We quantify the volume of ZDR and KDP columns to evaluate their utility in diagnosing temporal variability in lightning flash characteristics. Specifically, we analyze three severe storms that developed in environments with low-to-moderate instability and strong 0–6-km wind shear in northern Alabama during the 2016–17 VORTEX-Southeast field campaign. In these three cases (a tornadic supercell embedded in stratiform precipitation, a nontornadic supercell, and a supercell embedded within a quasi-linear convective system), we find that the volume of the KDP columns exhibits a stronger correlation with the total flash rate. The higher covariability of the KDP column volume with the total flash rate suggests that the overall electrification and precipitation microphysics were dominated by cold cloud processes. The lower covariability with the ZDR column volume indicates the presence of nonsteady updrafts or a less prominent role of warm rain processes in graupel growth and subsequent electrification. Furthermore, we observe that the majority of cloud-to-ground (CG) lightning strikes a carried negative charge to the ground. In contrast to findings from a tornadic supercell over the Great Plains, lightning flash initiations in the Alabama storms primarily occurred outside the footprint of the ZDR and KDP column objects.

Significance Statement

This study quantifies the correlation between mixed-phase updraft intensity and total lightning flash rate in three severe storms in northern Alabama. In the absence of direct updraft velocity measurements, we use polarimetric signatures, such as ZDR and KDP columns, as proxies for updraft strength. Our analysis of polarimetric radar and lightning mapping array data reveals that the lightning flash rate is more highly correlated with the KDP column volume than with the ZDR column volume in all three storms examined. This contrasts with previous findings in storms over the central Great Plains, where the ZDR column volume showed higher covariability with flash rate. Interestingly, lightning initiation in the Alabama storms mainly occurred outside the ZDR and KDP column areas, contrary to previous findings.
The Role of Vascular Endothelial Dysfunction in Hypertension With Hearing Loss
Authors: Hou Yinjing , Liu Bo
Published: April 2024

Hypertension can cause hearing loss, but there is no clear definition of the mechanism(s) involved. The study aimed to explore the role of vascular endothelial dysfunction in hypertension with hearing loss. Patients with hypertension were divided into two groups based on hearing loss. Pure tone audiometry (PTA) and endothelial function testing were performed. A total of 216 (432 ears) hypertensive patients were divided into hypertension with hearing loss group (n = 104) and hypertension without hearing loss group (n = 112). The vascular endothelial biomarkers, ET-1 (endothelin-1) and vWF (von Willebrand factor) were significantly higher ( P < .05) in the hypertension with hearing loss group. RHI (reactive hyperemia index), ET-1, and vWF were the factors related to hearing loss. The area under the receiver operating characteristic (ROC) curve (AUC) of RHI in the diagnosis of hypertension with hearing loss was .652 (95% CI .552-.751, P = .005), and the Youden index was 26.2%. The AUC of ET-1 was .706 (95% CI .612-.799, P = .001), and the Youden index was 38.9%. The AUC of vWF was .617 (95% CI .512-.721, P = .003), and the Youden index was 28.1%. Vascular endothelial dysfunction may play a role in the pathogenesis of hypertension with hearing loss.
A Longitudinal, Observational, and Descriptive Study About Benefits of Craniosacral Therapy in Child Neurodevelopment
Authors: León-Bravo Gema , Cantarero-Carmona Irene
Published: April 2024

Introduction: Coordination and balance are progressive motor skills that guide physical therapists in recognizing abnormal patterns during childish neurodevelopment. We aim to compare the efficacy of craniosacral therapy (CST) together with balance and coordination therapy (BCT) vs traditional BCT during neurodevelopment. Methods: Longitudinal, observational, and descriptive study with 111 apparently healthy children divided into 4 groups: craniosacral-balance and coordination therapy placebo (CS-BCTp), craniosacral-balance and coordination therapy (CS-BCT), balance and coordination therapy placebo (BCTp), and balance and coordination therapy (BCT). Results: Significant changes have been observed with the CS-BCT from the fourth session. Balance and coordination therapy is less effective. There are differences in the Battelle Scale at the beginning and after the 7 therapy sessions in the CS-BCT group. Conclusions: The study shows that CST together with balance and coordination exercises can be a more effective and faster treatment to improve these motor skills, correcting and improving alterations during child neurodevelopment.
In situ compressive behavior of carbon fibers reinforced PolyEtherEther Ketone laminates exposed to one-sided heat flux
Authors: Vieille Benoit , Coppalle Alexis
Published: April 2024

This study investigates the influence of a combined thermal heat flux (imposed by a cone calorimeter) and a compressive loading on the deformation and damage mechanisms within quasi-isotropic carbon fibers reinforced PolyEtherEther Ketone laminates. Thermogravimetric Analyses conducted at increasing heating rates under nitrogen (from 5 to 500°C/min) provide valuable information on the thermal decomposition of C/PEEK that ranges from 550°C to 627°C, with a corresponding mass loss ranging from 20 to 26%. From the thermo-mechanical coupling standpoint, the softening and the thermal decomposition of the PEEK matrix under a 50 kW/m2 heat flux result in the micro-buckling of fibers bundles in matrix-rich areas at the ply scale. Ultimately, it leads to the formation and propagation in the transverse direction of plastic kink bands at the laminates scale. Post-failure observations show that this macroscopic kinking propagates specifically according to the PEEK matrix pyrolysis.
Reporting and representation of underserved groups in intervention studies for patients with multiple long-term conditions: a systematic review
Authors: Kayani Zara , Willis Andrew , Salisu-Olatunji Shukrat O , Jeffers Shavez , Khunti Kamlesh , Routen Ash
Published: April 2024

Objectives

Globally, there is a growing number of people who are living with multiple long-term conditions (MLTCs). Due to complex management needs, it is imperative that research consists of participants who may benefit most from interventions. It is well documented that ethnic minority groups and lower socioeconomic status (SES) groups are at an increased risk of developing MLTCs. Therefore, the aim of this systematic review was to determine the level of reporting and representation of underserved groups (ethnic minority and low SES) in intervention studies addressing MLTCs.

Design

Systematic review. Four databases including Cochrane Library, MEDLINE, CINAHL and Scopus were searched for intervention studies from North America or Europe published between January 1990 and July 2023.

Setting

Hospital and community-based interventions. We included interventional studies focusing on improving MLTC-related outcomes.

Participants

Patients with MLTCs.

Main outcome measures

Total number of studies reporting on ethnicity and SES. Number and proportion of studies reporting by ethnic/SES group.

Results

Thirteen studies met the inclusion criteria. Only 4 of 13 studies (31%) recorded and reported ethnicity information. Of these four studies that reported on ethnicity, three studies consisted of primarily White participants. Ethnic minority groups were underrepresented, but one study included a majority of African American participants. Moreover, 12 of 13 studies (92%) reported on SES with income and educational level being the primary measures used. SES representation of higher deprivation groups was varied due to limited data.

Conclusions

For ethnicity, there was a lack of reporting, and ethnic minority groups were underrepresented in intervention studies. For SES, there was a high level of reporting but the proportion of study samples from across the spectrum of SES varied due to the variety of SES measures used. Findings highlight a need to improve the reporting and representation of ethnic minority groups and provide more detailed information for SES through using consistent measures (e.g. education, income and employment) to accurately determine the distribution of SES groups in intervention studies of people with MLTCs.