bluuebunny/crossref_metadata_2025 huggingface dataset:
Transforming The Management of Educational Institutions Through Strategy Formulation: Case Study at Yayasan Sosial dan Pendidikan Bina Muda Cicalengka
Authors: Fathur Alhadian  , Faoziah Ulfah Fatmawati
Published: June 2024

Education significantly contributes to the quality of human resources in a country. However, Indonesia currently faces educational challenges, with uneven quality and quantity across institutions. Therefore, strategic planning is crucial to enhance education quality at all levels. This study aims to formulate strategies for improving the management of Yayasan Sosial dan Pendidikan Bina Muda Cicalengka. Employing a qualitative and quantitative approach, the research utilizes SWOT and QSPM methods. The findings yield eight consecutive alternative strategies: 1) Developing collaborations and partnerships to enhance internal quality and funding sources, 2) Improving the competence and qualifications of human resources according to national standards, 3) Establishing policies and technical standards for educational management through an integrated information system 4) Enhancing motivation, discipline, and work ethic among human resources, 5) Optimizing information technology for monitoring educational institution performance, 6) Improving educational facilities, 7) Efficiently allocating budget plans, and 8) Enhancing socialization and promotion to boost the institution's reputation in the community. This study's limitation lies in its sole focus on enhancing organizational capacity from an internal perspective. Therefore, future research could delve into external aspects or a combination of both and utilize the Five Forces Porter's analysis method as its analytical tool.
The Evolution of Scientific Evidence Theory in Criminal Law: A Transformative Insight
Authors: Bakhtiar Handar Subhandi
Published: June 2024

Criminal law evolution accentuates the contrast between traditional eyewitness testimonies and precise modern forensics. While testimonies offer depth, scientific methodologies provide unparalleled accuracy in investigations. This study examines the challenges and merits of both in light of technological advancements. The objective is to understand the evolving paradigm of scientific evidence in criminal justice, emphasizing its integration and balance with traditional evidentiary methods for upholding judicial integrity and revealing material truth. The result of this study is historical evolution in the theory of scientific evidence which has transitioned from relying on testimonies to verifiable scientific data, including advancements in DNA and cyber technology. This scientific approach, characterized by its objectivity, replicability, and measurability, offers a robust foundation for discerning truth and justice, surpassing the limitations of mere factual accounts. Modern criminal law’s integration of this evidence signifies a deep-rooted commitment to justice, ensuring verdicts are swift, fair, and grounded in undeniable truth.
Profunda artery perforator free flaps for breast reconstruction
Authors: Olla Danielle , Levy Jacob , Nelson Jonas A. , Allen Robert J.
Published: June 2024

The gold standard for post-mastectomy autologous breast reconstruction is abdominally based free flaps. For patients with contraindications to abdominal free flap reconstruction, utilization of other donor sites should be considered. The profunda artery perforator flap has become a popular option for autologous reconstruction as it offers many advantages, including a long pedicle, muscle preservation, and easy soft tissue contouring. This review will provide an extensive outline of the history, anatomy, clinical indications, surgical techniques, and outcomes of the profunda artery perforator flap. It will also discuss appropriate preoperative imaging (CTA, MRA) and present a case of a patient who received a profunda artery perforator flap at our institution.
Penetapan Pencatatan Perkawinan Beda Agama Pasca Surat Edaran Mahkamah Agung Nomor 2 Tahun 2023 Tinjauan Yuridis Terhadap Putusan Pengadilan Negeri Jakarta Utara (Nomor: 423/Pdt.P/2023/Pn.Jkt.Utr)
Authors: Harahap Sarah Azzura , Prihatinah Tri Lisiani , Faradz Haedah
Published: June 2024

Pencatatan perkawinan beda agama dilaksanakan melalui  penetapan pengadilan. Tujuan dalam penelitian ini adalah untuk mengetahui dasar pertimbangan hukum hakim pengadilan negeri Jakarta Utara Nomor: 423/Pdt.P/2023/Pn.Jkt.Utr dalam mengabulkan permohonan pencatatan perkawinan beda agama dan  mengetahui akibat hukum dikeluarkannya Surat Edaran Mahkamah Agung Nomor 2 Tahun 2023.  Penelitian ini menggunakan metode pendekatan yuridis normatif dengan spesifikasi penelitian preskriptif. Sumber data yang digunakan adalah data sekunder. Metode pengumpulan data dilakukan dengan studi kepustakaan. Berdasarkan penelitian diperoleh hasil bahwa hakim dalam memutus perkara Nomor: 423/Pdt.P/2023/Pn.Jkt.Utr. mempertimbangkan ketentuan Pasal 35 Huruf a Undang – Undang Nomor 23 Tahun 2006 tentang Administrasi Kependudukan, Pasal 50 ayat (3) Peraturan Menteri Dalam Negeri Republik Indonesia Nomor 108 Tahun 2019 tentang Peraturan Pelaksanaan Peraturan Presiden Nomor 96 Tahun 2018 Tentang Persyaratan dan Tata Cara Pendaftaran Penduduk dan Pencatatan Sipil, serta fakta bahwa Para Pemohon menikah secara Katholik. Putusan tersebut bertentangan dengan Surat Edaran Mahkamah Agung Nomor 2 Tahun 2023 tentang Petunjuk Bagi Hakim Dalam Mengadili Perkara Permohonan Pencatatan Perkawinan Antar-Umat yang Berbeda Agama dan Kepercayaan dan Pasal 2 Ayat (1) jo Pasal 8 Huruf f Undang- Undang Nomor 1 Tahun 1974 tentang Perkawinan. Sehingga, hakim seharusnya dapat menambahkan kedua peraturan tersebut sebagai dasar pertimbangannya. Surat Edaran Mahkamah Agung Nomor 2 Tahun 2023 melahirkan akibat hukum perkawinan beda agama tidak dapat dicatatkan secara administratif kependudukan dan menutup celah hukum bagi perkawinan beda agama untuk mendapatkan pengakuan melalui penetapan pengadilan.
Implications of risk-reducing bilateral mastectomy among breast cancer susceptibility gene carriers: well-being and function
Authors: Erez Asnat Bar-Haim , Jacobs-Braun Rachel , Mor Pnina , Langer Danit
Published: June 2024

Background: Risk-reducing bilateral mastectomy (RRBM) is the most effective method for reducing the risk of breast cancer in women with breast cancer susceptibility gene (BRCA) mutations. There’s a paucity of knowledge regarding the broad implications of the surgery. This study aims to investigate RRBM’s effect on women’s activities of daily living, physical function, body image, and well-being. Methods: In total, 46 BRCA mutation carriers (n = 22 underwent RRBM; n = 24 control group) participated. Participants answered online questionnaires such as Quick Disabilities of the Arm Shoulder and Hand, Personal Well-being Index, WHODAS, Body Image Scale, and McGill Pain Questionnaire. Findings: Women who underwent RRBM reported a decline in body image and intimacy. However, they described improved health-related well-being and less fear of cancer than the control group. Women felt that there was insufficient support in the complex physical and functional recovery from the surgery. Conclusions: Most women felt the advantages of the surgery; however, it appears that more professional assistance focusing on daily living and physical function could be valuable in the recovery process.
The Interplay of Supply Chain Integration and Marketing Strategies in Achieving Customer Satisfaction
Authors: Holloway Samuel
Published: June 2024

This study explores the dynamic interplay between supply chain integration and marketing strategies in achieving customer satisfaction. Through a qualitative approach involving semi-structured interviews with supply chain and marketing professionals, the research delves into how these traditionally distinct functions can be aligned to enhance operational efficiency and deliver superior customer experiences. Findings reveal that strategic alignment between supply chain management (SCM) and marketing fosters better coordination of product availability and service delivery, thereby meeting customer expectations consistently and enhancing brand loyalty. Information sharing and technological integration emerge as critical enablers, facilitating real-time data exchange and collaborative decision-making. The study also identifies challenges such as organizational silos, cultural resistance, and technological constraints that impede seamless integration, highlighting the need for proactive strategies to foster cross-functional collaboration. Additionally, the evolving roles of sustainability and customer-centricity are emphasized as key drivers for differentiating brands and achieving competitive advantage. By integrating sustainable practices and adopting a customer-centric approach, organizations can build stronger customer relationships and enhance their market position. The research underscores the importance of leadership support, investment in technology, and a collaborative organizational culture in overcoming integration barriers. The study’s findings provide actionable insights for organizations aiming to optimize their SCM and marketing strategies, drive innovation, and sustain growth in an increasingly complex and competitive business environment. This research contributes to the growing body of knowledge on supply chain and marketing integration, offering practical recommendations for achieving customer satisfaction and long-term success.
ASSOCIATIONS BETWEEN RBP4, FSHB AND EGF GENE POLYMORPHISMS AND REPRODUCTIVE TRAITS IN PIGS
Authors:   Department of Genetics, Faculty of Biotechnology and Animal Breeding, West Pomeranian University of Technology, Szczecin, Poland, KOWALEWSKA Monika , TERMAN Arkadiusz ,   Department of Genetics, Faculty of Biotechnology and Animal Breeding, West Pomeranian University of Technology, Szczecin, Poland, CHOMCZYŃSKA Oliwia ,   Department of Genetics, Faculty of Biotechnology and Animal Breeding, West Pomeranian University of Technology, Szczecin, Poland, WOJDAK-MAKSYMIEC Katarzyna ,   Department of Genetics, Faculty of Biotechnology and Animal Breeding, West Pomeranian University of Technology, Szczecin, Poland, POLASIK Daniel ,   Department of Genetics, Faculty of Biotechnology and Animal Breeding, West Pomeranian University of Technology, Szczecin, Poland, DYBUS Andrzej ,   Department of Genetics, Faculty of Biotechnology and Animal Breeding, West Pomeranian University of Technology, Szczecin, Poland
Published: June 2024

Genes encoding retinol binding protein 4 (RBP4), follicle stimulating hormone subunit beta (FSHB) and epidermal growth factor (EGF) have been proposed as candidate genes for reproduction traits in pigs. The study presented in this work aimed to find associations between variants of these genes and reproduction traits in pigs reared in Poland. Investigation included Polish Large White x Polish Landrace (n = 288) crossbreed and Yorkshire (n = 195) breed sows. Insertion-deletion polymorphism (indel) in EGF gene was determined by means of PCR (polymerase chain reaction) method, however single nucleotide polymorphism (SNP) in RBP4 and FSHB genes by means of PCR-RFLP (restriction fragment length polymorphism) method. Obtained results showed that total number born (TNB) and number born alive (NBA) in 1st, 2nd and 5th parities were associated with RBP4 gene variants, TNB and NBA in first two parities with FSHB variants, however both traits in all parities with EGF variants (p ≤ 0.05 or p ≤ 0.01). In case of RBP4 gene, heterozygous genotype (AB) was favorable for analyzed traits, however in relation to FSHB and EGF genes homozygous genotypes, AA and BB respectively. Obtained results indicate that polymorphism in three analyzed genes is associated with important reproductive traits of pigs kept in Poland.
Pengaruh Struktur Kepemilikan Terhadap Penghindaran Pajak dengan CSR sebagai Variabel Mediasi
Authors: Ramadhani Intan , Az'mi Yanis Ulul
Published: June 2024

Tax avoidance is a legal method for minimizing company taxes by exploiting loopholes in the tax system. Ownership structure plays an important role in a company's tax avoidance decisions, because the level of ownership can give rise to differences in attitudes in a company's decision-making, including decisions regarding tax avoidance activities. This research aims to analyze the mediating effect of corporate social responsibility ownership structure on tax avoidance. This research sample includes manufacturing companies listed on the Indonesia Stock Exchange. The sampling technique used in this research was purposive sampling, so the sample used amounted to 249 data. Path analysis is used as an analysis method. This research shows that ownership structure encourages corporate social responsibility practices in companies. The research results show that corporate social responsibility can mediate the influence of ownership structure on tax avoidance. The research provides main implications regarding the important role of social responsibility for companies to minimize the potential for tax avoidance.
The Effects of Carbon Tax, Fairness, and Government Trust on Public Views of Carbon Tax
Authors: Kusumawardhani Adhityawati , Saptadjaja Vanessa , Cahyono Megan
Published: June 2024

The research aim to investigate the impact of fairness, trust, and carbon taxation on public perceptions of carbon tax. The purposive sampling procedure was employed to conduct this quantitative research. Indonesia’s primary contributor to carbon emissions is Java Island, which accounts for approximately 60% of the nation’s total emissions. The survey was administered online to 200 residents of the island. The populix/poplite platform was employed to draw the sample. SPSS was employed to perform multiple regression analysis. The findings of this investigation indicate that the public’s perceptions of Java are substantially influenced by fairness, trust, and carbon taxes. These findings indicate that the public is of the opinion that the carbon tax will be applied equitably and will have a positive impact on the environment. This research bolsters the public of view theory, which is crucial for the government to comprehend the critical factors that influence public acceptance and support for policy measures aimed at achieving sustainable objectives in the context of environmental policy. Additionally, it contributes to a more profound comprehension of the dynamics of public opinion in the context of climate change.
Implementation of Imam Al-Ghazali's Perspective Character Values in Nahwu Learning at UMALA
Authors: Amalia Dian Risky , Huda Miftahul , Sugirma Sugirma , Hidayat Ahmad Fadhel Syakir , Sulaikho Siti
Published: June 2024

تم العثور على العديد من مرتكبي الاحتيال في الأكاديميين وهم محور المشاكل التي يتعرض لها الإهتمام إلى كفاءة المعلمين في عملية التعلم الخاصة بهم. يزيد من التدقيق العام في كفاءة المعلمين الذين يفتقرون إلى غرس قيم الشخصية في تعلمهم. إن تطبيق قيم الشخصية في تعلم اللغة على أساس  الإمام الغزالي هو هدف صالح في هذه الدراسة، وتحديداً في الموازنة بين المعرفة و "الأعمال". منهج البحث وصفي ويستخدم منهجًا كميًا ، وهو مقياس ليكرت مع أسلوب أخذ العينات غير الاحتمالية ، أي أخذ العينات الكلية من طلاب الفصل الثالث المتخصصين في تعليم اللغة العربية. نتج عن هذا البحث تصور الشخصيات الأربع الرئيسية على أساس الإمام الغزالي ، وهي الحكمة والشجاعة والسماحة والعدل التي يمكن تنفيذها في تعلم النحوى. أظهرت النتائج أن 96٪ موافقون بشدة ومتفقون ومعتدلون ، و 4٪ غير موافقين ، بحيث لم يحصلوا فقط على نظرية قواعد النحوية ولكن أيضًا على قيم الشخصية التي يمكن أن يطبقوها معًا. بناء على التوازن بين العلم العمل التي لها أثرها على البعد الاجتماعي، وهي مفتاح الحصول على السعادة في الدنيا والآخرة.
الكلمات المفتاحية: التنفيذ ، القيم الشخصية ، الإمام الغزالي ، النحو.
Effectiveness of Memorizing The Qur’an on Arabic Vocabulary Mastery Among Students at Ar-Rahmah Boarding School for Tahfīdz Qur’an Balikpapan
Authors: Hidayat Tatang , Sagala Sadiyah Ratnasari , Istianah Istianah , Khatimah Husnul , Qosim Muhammad Nanang , Balah Abdel Rahman Elsayed Elsayed Abdel Ghaffar
Published: June 2024

This research aims to find out the influence of the ability to memorize the Qur'an  on the Arabic vocabulary mastery among students of the boarding school for tahfīdz Qur’an Balikpapan, and follows the analytical descriptive approach to this goal. The methods used by the researcher to collect data are testing, observation and documentation. It is quantitative research with the design of causal association research with a sample of 31 students from the second stage in the preservation of the Qur'an. For data analysis, the researcher used regression equation, selection factors and importance testing. The results of this research show that there is a significant impact of the preservation of the Qur'an with the mastery of Arabic vocabulary. By calculating the importance test analysis that indicates that tvalue (7,482) is greater than ttable (2,045), H0 was rejected and H1 was accepted, which means that there is a significant influence between the ability to memorize  the Qur’an to the Arabic vocabulary mastery. The percentage of the influence of Qur'anic memorization ability on the ruling of Arabic vocabulary is 65.9%, and 34.1% by other factors.
Keywords: Memorization, Al-Qur'an, Mastery, Arabic Vocabulary, Boarding School for Tahfīdz Qur’an
Feasibility and effectiveness of real time digital postoperative follow-up following bariatric surgery
Authors: Farinella Eleonora , Papakonstantinou Dimitrios , Koliakos Nikolaos , Maréchal Marie-Thérèse ,   Mathilde Poras1, Pau Luca , Requière Arnaud , Plumacker Alain , Briganti Giovanni
Published: June 2024

Introduction: With the global prevalence of obesity steadily increasing, bariatric surgery has gained significance in managing this health challenge. Fast-track healthcare pathways have shown promise in improving outcomes and patient satisfaction for bariatric surgery. In this study, we aimed to evaluate the safety and effectiveness of real-time digital postoperative follow-up using a smartphone application.Materials and methods Consecutive patients undergoing bariatric surgery at CHU Saint-Pierre university hospital between September 2022 and October 2023 were prospectively enrolled. Patients were instructed to download and install the application on their smartphones, which prompted them with predetermined daily questions. Depending on their responses, alerts could be generated for review by medical staff A three-tiered alert system (orange, red, red+) was implemented to signify increasing significance.Results During the study period, a total of 1119 alerts were recorded from 104 patients, with 39.3% occurring within the first seven postoperative days. Patient alert profiles were significantly associated with postoperative outcomes, with worsening outcomes observed from basic orange alerts to red + alerts. Patients with red + alerts had nearly a threefold increase in postoperative morbidity rates, emergency department visits, and readmissions. No significant differences in weight loss outcomes were observed. Patient response adherence was 67.5%, while the overall satisfaction with the use of the application was 94%.Conclusion Remote follow-up via a mobile application holds promise for enhancing the management of bariatric surgery patients, complementing traditional practices. The implementation of a three-tiered alert system may help identify patients at risk of serious complications, potentially reducing unnecessary emergency department and hospital resource utilization.
Fracture Toughness of Ovine TMJ Disc: Effects of Crack Length and Orientation
Authors: Salehipour saeed , Hashemi Ata
Published: June 2024

The human mandible experiences mechanical stress from several directions as a result of activities such as speaking, chewing, and other everyday actions. The TMJ disc facilitates mandibular motion and absorbs all of the stresses associated with daily activities. Thus, the TMJ disc is likely to be susceptible to rupture. Hence, it is crucial to investigate its susceptibility to failure and rupture. The aim of this study was to determine the impact of fracture orientation, sample thickness, and crack-to-width ratio on the amount of energy needed to cause the growth of flaws on the disc. Fracture toughness was investigated by conducting cyclic tensile testing on 40 ovine TMJ discs in two different notch orientations: anteroposterior and mediolateral. The J-integral was chosen as a measure of the critical fracture energy of the TMJ disc. The Shapiro-Wilk test showed that fracture toughness data did not follow a normal distribution (P-value < 0.05). Due to unequal variances, the Kruskal-Wallis test was used to examine the data. The study revealed that the fracture toughness in the anteroposterior direction was much higher than that of the mediolateral, indicating a superior ability to resist tearing and fracture in the anteroposterior direction. Furthermore, the study's findings revealed that both the direction of the crack and its initial crack-to-width ratio influenced the TMJ disc's fracture toughness. The study also evaluated TMJ disc failure patterns to better understand its pathophysiology. The results showed that the crack growth profile in two orientations has a completely different structure. The 2D finite element analysis results also indicated a significant relationship between the fracture toughness and the percentage of cracks, demonstrating that increasing the crack-to-width ratio leads to a rise in fracture toughness. These findings help understand TMJ injuries to the disk and develop better treatments.
Prevalence and predictors of condom use among people who inject drugs in Georgia
Authors: Kajaia Maia , Butsashvili Maia , DeHovitz Jack A. , Kamkamidze George , Gulbiani Lasha , Abzianidze Tinatin , DjibutiMD Mamuka
Published: June 2024

Background
People who inject drugs (PWID) are more likely to engage in risky sexual behavior placing them at high risk of acquiring HIV and other STIs. This study aims to assess the prevalence and predictors of inconsistent condom use with casual and/or paid sexual partners among PWID in Georgia.
Methods
Integrated Bio-Behavioral Surveillance Survey was conducted among PWID in seven major cities of Georgia. Study design was cross-sectional with respondent-driven sampling (RDS) methodology. Data collection was carried out through individual face-to-face interviews. In this paper we analysed subsample of 619 PWID who reported having casual and/or paid sexual partners during last 12 months and described prevalence and predictors of consistent condom use.
Results
Consistent condom use during casual and/or paid sex in past 12 months was reported by 49.4% of respondents. The likelihood of consistent use with casual and/or paid sexual partners was statistically significantly associated with residence, family income, drug use frequency, drug dependance and HIV risk self-perceptions. In multivariate analysis independent predictors of always using condom at casual/paid sex during the last 12 months were place of residence (aOR = 6.4; 95% CI: 3.2–12.7), family income (aOR = 2.1; 95% CI:1.3–3.5) and drug use frequency (aOR = 0.6; 95% CI: 0.4–0.9).
Conclusion
The study revealed low prevalence of consistent condom use with casual and/or paid sexual partners among PWID in Georgia. Integration of safe sex educational interventions in harm reduction services will improve the rates of condom use among PWID and should focus PWID with lower socio-economic status and residing outside capital city.
Puerariae Flos promotes apoptosis through the ESR1-ERK1/2 signaling pathway to intervene in alcoholic hepatocellular carcinoma
Authors: Li Jun , An Mingyu , Cheng Guo , Luo DiDong , Zhang Nannan
Published: June 2024

Ethnopharmacological relevance: Increasing evidence indicates that conventional traditional Chinese medicine (TCM) plays a cardinal role in oncological remedies. Initially, our research group focused on research related to the sobering-up and liver-protecting effects of Gehua jiecheng fang, and found that these plants also have anticancer properties. Among these pathogens, Puerariae Flos (PF) is the main component of the fungus, and there is also literature supporting the use of PF for HCC care.
Aim of the study: PF is utilized to treat tumors in China. However, its effect on and mechanism involved in alcohol-associated hepatocellular carcinoma (alcohol-related HCC) remain elusive. This investigation aimed to address this knowledge gap through experiments and bioinformatics.
Materials and methods: Limid chromatography-tandem mass spectrometry (LC‒MS/MS) was used as an initial method for identifying chemical compounds that were present in the drug sera. The prognostic DEGs were determined using univariate Cox regression analysis. The diagnostic value of the DEGs was estimated by constructing survival curves and utilizing the curved TCGA and GEO datasets, which are connected to alcoholic HCC according to their recipient operation characteristics (ROC). The affinity and stability between the target and predictive chemical compounds were checked by means of molecular docking and molecular dynamics simulations. Furthermore, the selected genes were subjected to clinical correlation analysis and KEGG analysis. The impact of PF on migration and cell proliferation was evaluated via western blotting.
Results: LC‒MS/MS revealed 68 components and identified 844 objects, 63 of which overlapped with the aims of patients with alcoholic HCC. Seven methods were used to determine that the ESR1 and CDK1 genes have advantages in the diagnosis of alcoholic HCC. Molecular docking and molecular dynamics demonstrated strong binding affinities between key components andESR1. Pathway analysis revealed that the two core genes were involved in apoptosis in a complex manner, with ESR1 showing enrichment in the chemogenic receptor activation pathway. The diagnostic significance of ESR1 was confirmed by Western blot and in vitro experiments.
Conclusion: PF inhibits the migration and proliferation of alcohol-related HCC cells by regulating the ESR1/ERK1/2 pathway to promote cell apoptosis.
Exploring the role of new angiogenic tracer, 68Ga-DOTAGA-IAC and comparison of its diagnostic performance with 18F-FDG PET/CT in patients with radioiodine refractory differentiated thyroid carcinoma
Authors: Kumar Srinivas Ananth , Sood Ashwani , Kumar Rajender , Shukla Jaya , Mittal Bhagwant Rai
Published: June 2024

Introduction: Integrin antagonist carbamate (IAC) – a newer αvβ3 integrin antagonist peptidomimetic molecule in the pipeline, has made the molecular imaging of tumour angiogenesis amenable. The study aims to investigate the biodistribution, clinical efficacy of 68Ga DOTAGA-IAC PET/CT in the detection of radioiodine refractory differentiated thyroid carcinoma (RAIR-DTC), to compare its diagnostic performance with the most commonly used imaging tool, 18F-FDG PET/CT.
Materials and methods: This prospective pilot study included RAIR-DTC patients who underwent whole-body 18F-FDG-PET/CT followed by 68Ga-DOTAGA-IAC PET/CT. For each patient, using organ specific circular regions of interest (ROIs) were evaluated in 16 anatomical structures on 68Ga-DOTAGA-IAC PET/CT to find out the biodistribution. A five-point grading system was proposed for the radiotracer uptake on 68Ga-DOTAGA-IAC PET/CT. Abnormal, non-physiologic radiotracer uptake (grade II and higher-grade lesions showing tracer uptake more than the mediastinal bloodpool) at a site congruous with disease activity was considered positive finding. The imaging findings of both the PET/CT were interpreted and quantitative parameters like SUVmax, MTV and TLG were obtained and statistically analyzed.
Results: For the biodistribution, maximum physiological tracer uptake was identified in the kidneys followed by spleen. 18F-FDG PET/CT detected 97 lesions (excluding the lung nodules) in 30 patients, majority of them being nodal lesions (73.2%) followed by skeletal lesions (15.5%). 68Ga-DOTAGA-IAC PET/CT detected 34 lesions (lung nodules were not taken into consideration similar to 18F-FDG PET/CT) in 14 patients. Out of the 34 lesions, 50% were nodal lesions. Few of the analysed patients had multiple grade lesions, with 20% of them having coexisting higher grade lesions (grade II and higher lesions) consistent with disease activity on 68Ga-DOTAGA-IAC PET/CT. The median SUVmax values of the lesions at all sites and volumetric parameters like median total MTV and TLG on FDG PET/CT outperformed IAC PET/CT.
Conclusion: Angiogenesis imaging with 68Ga-DOTAGA-IAC PET/CT appears to be inferior in the detection of lesions in patients with RAIR-DTC compared to 18F-FDG PET/CT, retaining the domination of FDG PET/CT imaging in clinical practice.
Heteronymous feedback from quadriceps onto soleus in stroke survivors
Authors: Cuadra Cristian , Wolf Steven L. , Lyle Mark A.
Published: June 2024

Background:
Recent findings suggest increased excitatory heteronymous feedback from quadriceps onto soleus may contribute to abnormal coactivation of knee and ankle extensors after stroke. However, there is lack of consensus on whether persons post-stroke exhibit altered heteronymous reflexes and, when present, the origin of increased excitation (i.e. increased excitation alone and/or decreased inhibition). This study examined heteronymous excitation and inhibition from quadriceps onto soleus in paretic, nonparetic, and age-matched control limbs to determine whether increased excitation was due to excitatory and/or reduced inhibitory reflex circuits. A secondary purpose was to examine whether heteronymous reflex magnitudes were related to clinical measures of lower limb recovery, walking-speed, and dynamic balance.
Methods:
Heteronymous excitation and inhibition from quadriceps onto soleus were examined in fourteen persons post-stroke and fourteen age-matched unimpaired participants. Heteronymous feedback was elicited by femoral nerve and quadriceps muscle stimulation in separate trials while participants tonically activated soleus at 20% max. Fugl-Myer assessment of lower extremity, 10-meter walk test, and Mini-BESTest were assessed in stroke survivors.
Results:
Heteronymous excitation and inhibition onsets, durations, and magnitudes were not different between paretic, nonparetic or age-matched unimpaired limbs. Quadriceps stimulation elicited excitation that was half the magnitude of femoral nerve stimulation. Femoral nerve elicited paretic limb heteronymous excitation was positively correlated with walking speed but did not reach significance because only a subset of paretic limbs exhibited excitation (n = 8, Spearman r = 0.69, P = 0.058).
Conclusions:
Heteronymous feedback from quadriceps onto soleus assessed in a seated posture was not impaired in persons post-stroke. Despite being unable to identify whether reduced inhibition contributes to abnormal excitation reported in prior studies, our results indicate quadriceps stimulation may allow a better estimate of heteronymous inhibition in those that exhibit exaggerated excitation. Heteronymous excitation magnitude in the paretic limb was positively correlated with self-selected walking speed suggesting paretic limb excitation at the higher end of a normal range may facilitate walking ability after stroke. Future studies are needed to identify whether heteronymous feedback from Q onto SOL is altered after stroke in upright postures and during motor tasks as a necessary next step to identify mechanisms underlying motor impairment.
Reliability of skinfold measurements and body fat prediction depends on the rater's experience: a cross-sectional analysis comparing expert and novice anthropometrists
Authors: Machado Dalmo Roberto Lopes , Silva Leonardo Santos Lopes da , Vaquero-Cristóbal Raquel , Rosa Victor Carvalheiro , Júnior Marcio Fernando Tasinafo , Santos André Pereira dos , Abdalla Pedro Pugliesi , Mazzonetto Lisa Fernanda , Oliveira Alcivandro Sousa , Mota Jorge , Marcos-Pardo Pablo Jorge
Published: June 2024

In this study, we aimed to identify the variability among anthropometrists with varying levels of experience and its effects on the final interpretations of body composition estimates. Were implied 25 male university students, aged between 18 and 30 years. Skinfold measurements of eight body regions were obtained by two anthropometrists: an expert (more than 20 years of experience) and a novice (initial basic training). The same calibrated adipometer was used to verify the %fat. The results showed that the expert technical error of measurements (TEM) was below the tolerated limits (< 5%) for all skinfold measurements, while the novice exceeded the rater (> 7.5%) for the iliac crest and abdominal skinfolds. The inter-evaluator reliabilities were good for triceps, subscapular, and calf skinfolds; moderate for iliac crest, abdominal, and thigh skinfolds; but poor for biceps skinfolds. Some TEM novice measurements were 2 to 4 times higher than expert. The Bland & Altman analysis showed that inter-evaluator reliabilities were good for triceps, subscapular, and calf (p < 0.001). However, the inter-evaluator reliabilities were moderate for iliac crest, abdominal, and thigh (p < 0.001), and poor for biceps (p = 0.07). There was a significant impact on the predicted %fat, with estimates up to 55.12% higher by the novice compared to the expert. Conclusively, low reliability in estimating body fat emphasizes the importance of measurement training. Measurements by anthropometrists with low expertise levels are unreliable even with standardized protocols and equally calibrated instruments.
Shockwave lithotripsy paves the way for drug coated balloon in calcific in- stent restenosis: a case report
Authors: Zaalouk Sedky , Elwany Mostafa
Published: June 2024

Background
Drug-coated balloons (DCB) have been well-studied as a modality of percutaneous intervention (PCI) for the management of in-stent restenosis (ISR) in numerous trials. Proper lesion preparation has been the Achilles heel for DCB and is essentially the cornerstone for its proper use. Shockwave intravascular lithotripsy (IVL) is considered one of the safe and effective techniques for cracking heavy coronary artery calcifications (CAC) to allow proper stent expansion. There have been a few reports illustrating the safety and efficacy of the use of IVL technology to achieve satisfactory stent expansion in heavily calcific ISR.
Case presentation
In this report, we are presenting a resistant calcific ISR in a post coronary artery bypass surgery (CABG) patient which was successfully managed by IVL followed by DCB.
Conclusions
IVL followed by PCI using DCB has been shown to be safe and effective in cases of ISR with dense CAC. The technique needs to be further assessed by more studies to be adopted on a wider scale.
The association of energy, macronutrients, and food sources consumption at dinner versus breakfast with obesity: The National Health and Nutrition Examination Survey (NHANES), 2003-2016
Authors: hou wanying , wang weiqi , sun changhao
Published: June 2024

Background
This study aimed to investigate the association of the difference of dietary consumption (energy, macronutrients, and foods) at dinner versus breakfast with obesity among U.S adults.
Subjects/Methods:
This study adopted the data from the National Health and Nutrition Examination Survey (2003–2016), involving a total of 27911 participants. The differences in the ratio of total energy and three macronutrients with six subgroups at dinner versus breakfast (ΔRatio) were categorized into quartiles. The differences in the consumption of 17 types of food at dinner versus breakfast (ΔFoods) were considered as continuous variables. Body Mass Index (BMI) and Waist circumference (WC) were used to define general obesity (30.0 ≤ BMI < 40.0), morbid obesity (BMI ≥ 40.0), and abdominal obesity (WC > 102 cm for men or WC > 88 cm for women). Multiple logistic and linear regression models were developed.
Results:
After a variety of covariates were adjusted, participants in the highest quartile (higher energy/macronutrient intake at dinner than breakfast) of ΔRatio in terms of energy, fat, saturated fatty acids (SFA), and unsaturated fatty acids (USFA) was positively associated with morbid obesity compared with those in the lowest quartile (ORΔRatio of energy 1.27, 95%CI 1.01;1.61; ORΔRatio of fat 1.27, 95%CI 1.01;1.60; ORΔRatio of SFA 1.27, 95%CI 1.01;1.59; ORΔRatio of USFA 1.28, 95%CI 1.02;1.59). The highest quartile of ΔRatio of low-quality carbohydrate led to higher odds of abdominal obesity (ORΔRatio of low−quality carbohydrate 1.16; 95%CI 1.03–1.31). Meanwhile, ΔRatio of low-quality carbohydrates was significantly positively associated with BMI (coefficient: 0.562, 95%CI: 0.217–0.907). ΔFoods including whole fruits, other starchy vegetables, added sugars, poultry, dairy, and nuts were positively associated with obesity.
Conclusions:
This study indicated that among US adults, higher intake of energy, macronutrients (low-quality carbohydrate, fat, SFA, and USFA), and foods (whole fruits, other starchy vegetables, added sugars, poultry, dairy, and nuts) at dinner than breakfast was associated with higher odds of having obesity. In conclusion, this study emphasized the importance of diet quality and meal-timing in the prevention of obesity.
Computational modeling of insect odorant receptors: A comparative analysis of Template-based and Alphafold modeling
Authors: Jabeen Amara , Oakeshott John , Lee Siu Fai , Ranganathan Shoba , Taylor Phillip W.
Published: June 2024

Insects rely on odorant receptors (ORs) to detect and respond to volatile environmental cues, so the ORs are attracting increasing interest as potential targets for pest control. However, experimental analysis of their structures and functions faces significant challenges. Computational methods such as template-based modeling (TBM) and Alphafold2 (AF) could facilitate the structural characterisation of ORs. This study first showed that both models accurately predicted the structural fold of MhOR5, a jumping bristletail OR with known experimental 3D structures, although accuracy was higher in the extracellular region of the protein and binding mode of their cognate ligands with TBM. The two approaches were then compared for their ability to predict the empirical binding evidence available for OR-odorant complexes in two economically important fruit fly species, Bactrocera dorsalis and B. minax. Post-simulation analyses including binding affinities, complex and ligand stability and receptor-ligand interactions (RLIs) revealed that TBM performed better than AF in discriminating between binder and non-binder complexes. TBM’s superior performance is attributed to hydrophobicity-based helix-wise multiple sequence alignment (MSA) between available insect OR templates and the ORs for which the binding data were generated. This MSA identified conserved residues and motifs which could be used as anchor points for refining the alignments.
Promoting the mental health and well-being of vulnerable youth through art: A descriptive qualitative study
Authors: Simons Kyra , Mendrek Adrianna , Piché Jasmine , Bernier Megan , Léger-Goodes Terra , Malboeuf-Hurtubise Catherine
Published: June 2024

Background: Children in rural communities represent some of the most vulnerable populations in Canada, posing implications for their mental health and well-being, particularly regarding their access to mental health services. Art-based interventions are accessible, but not thoroughly validated.
Aim:The purpose of this project was to offer an art-based intervention for a very specific population benefiting from an after-school program in rural Quebec.
Methods: Youth in Quebec, Canada, took part in a 7-week art-based intervention. A descriptive design was implemented to examine the implications this intervention had on students, particularly their mental health and well-being.
Results:The majority of students described enjoying the intervention, many stating it had a positive impact on their lives. Students reported feeling positively during art-making and expressed interest in taking part in follow-up research.
Discussion: Positive experiences with the present intervention support existing literature regarding the effectiveness of art-based methods for youth populations.
Numerical and parametric study of the thermal performance of a latent storage unit
Authors: Sebbar El Hassan , Labtira Abdelkrim
Published: June 2024

Latent heat storage is an advanced technology with advantages for heating and cooling systems, including load displacement, flexibility, and energy savings. By accumulating thermal energy efficiently during low-demand periods and using it during high-demand periods. This reduces environmental impact, and financial savings, and increases system reliability. This work aims to study numerically a latent heat storage system. This system consists of a tank filled with a phase-change material (PCM); the tank is crossed by a heat transfer fluid to charge the PCM with thermal energy. this process follows the evolution of the PCM temperature and the tank outlet temperature during the charging period. A thorough parametric study analyzes the thermal and dynamic performance of the system and studies the effect of several parameters, including tank height, HTF mass flow rate, PCM layer thickness, and the amount of energy stored during charge. The system was modeled using computational fluid dynamics (CFD) to simulate PCM phase change phenomena. Validation of the numerical model showed excellent agreement with experimental results. It was observed that a higher mass flow rate leads to a shorter storage time and lower stored energy, with values of 19.2563 kWh for a flow rate of 0.6 kg/s and 20.1642 kWh for a flow rate of 0.4 kg/s.
Expression and regulation of SETBP1 in the song system of male zebra finches (Taeniopygia guttata) during singing
Authors: Grönberg Dana Jenny , Carvalho Sara Luisa Pinto , Dernerova Nikola , Norton Phillip , Wong Maggie , mendoza ezequiel
Published: June 2024

Rare de novo heterozygous loss-of-function SETBP1 variants lead to a neurodevelopmental disorder characterized by speech deficits, indicating a potential involvement of SETBP1 in human speech. However, the expression pattern of SETBP1 in brain regions associated with language remains poorly understood, along with the underlying molecular mechanisms linking it to speech. In this study, we examined SETBP1 expression in the brain of male zebra finches, a well-established model for studying vocal production learning. We demonstrated that zebra finch SETBP1 exhibits a greater number of exons and isoforms compared to its human counterpart. We characterized a SETBP1 antibody and showed that SETBP1 colocalized with FoxP1, FoxP2, and Parvalbumin in key song nuclei. Moreover, SETBP1 expression in neurons in Area X is significantly higher in zebra finches singing alone, than those singing courtship song to a female, or non-singers. Importantly, we found a distinctive neuronal protein expression of SETBP1 and FoxP2 in Area X only in zebra finches singing alone, but not in the other conditions. We demonstrated SETBP1´s regulatory role on FoxP2 promoter activity in vitro. Taken together, these findings provide compelling evidence for SETBP1 expression in brain regions to be crucial for vocal learning and its modulation by singing behavior.
Lightweight design of inner hub of coated steel strapping machine based on topology optimization
Authors: Li Xihan , Wei Yulan , Zhang Qingzhu , Shen Hua , Gao Weiqian , Ding KunYing
Published: June 2024

Aiming at the current situation of the demand for low energy consumption, long life and high efficiency of the coated steel bar strapping machine, topology optimization and orthogonal test method are combined to carry out lightweight research on the inner hub of the strapping machine. Based on the results of the static analysis, and taking the minimum structural flexibility as the research objective, the optimized dimensions are designed and the topology optimization model of the inner hub is established, the orthogonal test is simulated by ANSYS, and the least-squares regression equation is established to obtain the optimized mathematical model of the inner hub. The static analysis of the optimized inner hub model is carried out, and the comparison results show that the weight is reduced by 23.06% under the requirement of meeting the working needs of the inner hub.
Neuritin attenuates neuroinflammation and apoptosis in early brain injury after subarachnoid hemorrhage via endoplasmic reticulum stress-related inflammatory pathways
Authors: Ren Kunhao , Dai Linzhi , Zhang Hao , He Yaowen , Liu Bin , Hu Youjie , Ma Ketao , Tian Weidong , Zhao Dong
Published: June 2024

Neuroinflammation is a key destructive pathophysiological process in early brain injury (EBI) following subarachnoid hemorrhage (SAH). Recent studies have discovered that endoplasmic reticulum stress-related inflammatory pathways include the IRE1α-TRAF2-NF-κB pathway, PERK-eIF2α-NF-κB pathway, and ATF6-AKT -NF-κB pathway leading to neuroinflammatory response. Neuritin is a neurotrophin that is involved in neuronal plasticity and regeneration. Studies have suggested that Neuritin has a vital role in reducing neuroinflammation, and can also decrease the expression of proteins related to endoplasmic reticulum stress following SAH. This suggests that Neuritin could be a potential therapeutic target for SAH and other neurological conditions. However, the regulatory mechanisms of Neuritin in ER stress-related inflammatory pathways after SAH are not yet fully understood. In this work, we discovered that the activation of ER stress-related inflammatory pathways leads to neuroinflammation, which further aggravates neuronal apoptosis after SAH. Our findings indicate that Neuritin overexpression play a neuroprotective role by inhibiting IRE1α-TRAF2-NF-κB pathway, PERK-eIF2α-NF-κB pathway, and ATF6-AKT-NF-κB pathway associated with endoplasmic reticulum stress. These inhibitory effects on neuroinflammation ultimately reduce nerve cell apoptosis.
Gis Based Hydrological Modelling for Urban Flood Simulation Using Soil and Water Assessment Tool (SWAT)
Authors: Jawale Priyanka , Thube A. D.
Published: June 2024

This study presents a comprehensive approach to flood analysis using GIS-based hydrological modeling, particularly focusing on the application of the Soil and Water Assessment Tool (SWAT) in the urban area of the Mula River, Wakad watershed. The (QSWAT) tool, which is the SWAT interface for QGIS, has been used in this study. By examining data spanning nearly three decades, valuable insights are provided into the trends and impacts of land-use changes on flood scenarios. The study area encompasses a delineated watershed and sub-basin parameters, comprising slope orientation, digital elevation model (DEM), soil classification and land cover. The principal objective is to formulate a runoff model leveraging a geospatial database to evaluate the influence of land-use class alterations on QSWAT outputs at the sub basin level. QSWAT, renowned as a river basin model, is leveraged to assess the ramifications of management decisions on water resources. This investigation illustrates the application of QSWAT for stream flow simulation in an experimental basin, employing daily and hourly rainfall observations to appraise the impact of rainfall resolution on model efficacy. The catchment area for this watershed covers an estimated drainage area of 603.446 hectares, divided into 28 sub-basins. It is observed that the trend in average annual rainfall is on the rise over time. The maximum surface runoff observed is 3206 mm, with an average annual surface runoff of 117.89 mm. Analysis reveals that surface runoff does not adhere to a specific pattern, but the frequency of flood occurrences is escalating over time. In summary, the QSWAT model effectively simulated and forecasted flow, offering insights into dynamics of urban flooding and highlights the importance of proactive measures in mitigating flood risks.