bluuebunny/crossref_metadata_2025 huggingface dataset:
Features of Takotsubo Syndrome in Male Patients
Authors: Karaoglanova Tat’yana E. , Manzyuk Aleksey V.
Published: December 2020

Takotsubo syndrome has particular significance among heart diseases, as with the increase in the number of publications, there is more and more evidence that this syndrome can cause serious complications and even death of patients. Similarity with acute coronary syndrome is even more important reason for interest in Takotsubo syndrome, coupled with the lack of a clear diagnostic criterion to distinguish these pathologies. The lack of understanding of the pathogenesis of Takotsubo syndrome is one of the obstacles to the formation of such a diagnostic criterion. Despite a large number of publications on the causes and pathogenesis of Takotsubo syndrome, course of the disease has not been studied in men, since this pathology is much more often observed in women. Identifying the gender characteristics of this disease and their causes can be an important step towards explaining the pathogenesis of Takotsubo syndrome. In this review, a sample of 45 clinical cases of Takotsubo syndrome in men was compared with a mixed group from a clinical study. Takotsubo syndrome in men has a number of distinctive features: the greater importance of physical stress in the structure of the causes, in contrast to the predominance of emotional stress in the mixed group, a higher proportion of the basal form of the disease, as well as a significant decrease in the ejection fraction of the left ventricle and the frequent occurrence of cardiogenic shock manifestations of a more severe course of this disease.
A Randomized Controlled Study of the Effectiveness of Electrophysiological Monitoring of Dexmedetomidine in Patients with Brain Damage of Various Origins
Authors: Kiryachkov Yuri Y. , Petrova Marina V. , Muslimov Bagautdin G. , Bosenko Sergey A. , Gorlachev Mikhail M.
Published: December 2020

Background.At the same time, the main effect of the use of this drug is the elimination of the autonomic nervous system dysfunction and sympatholysis. It seems important to search for a method of indications and selection of a dose of dexmedetomidine in intensive care.Aims to improve the clinical effectiveness of the electrophysiological navigation of the prolonged use of dexmedetomidine in patients with brain pathology of various origins.Methods.The study included 83 patients 2050 days after the traumatic brain injury, anoxic damage; consequences of acute disorders of cerebral. 37 patients comprised the 1st intervention group with a clinical course of dexmedetomidine (male 28; female 9; average age 49.62.3 years) and 46 patients comprised the 2nd control group without pharmacological correction with dexmedetomidine (male 23; female 23, average age 512.5 years). Criteria for the inclusion of prolonged infusion of the drug dexmedetomidine (Orion Pharma, Finland) are based on heart rate variability (HRV) indicators characteristic of sympathetic hyperactivity, the target task of titration of doses of dexmedetomidine served as the parameters for achieving normal HRV indicators, the appearance of parasympathetic hyperactivity served as the basis for reducing the dosage of the drug or stopping it of application. HRV parameters were recorded before dexmetomedine infusion-initially, on 13; 45; 910; 1520 days of drug administration.Results.The starting dose of dexmedetomidine with sympathetic hyperactivity in patients was 0.12 to 0.24 g.kg1.hr1(average dose 0.160.01; total 200 mg/day). According to digital data from HRV, the effective dose of dexmedetomidine ED50 was 0.260.03 g.kg1.hr1(total daily 353.835.1 g) and was achieved on day 910 using dexmedetomidine.Conclusions.The protective role of dexmedetomidine with correction of sympathetic hyperactivity based on electrophysiological navigation according to the HRV is reliable in the following indicators: The improvement of consciousness; a significant decrease in the incidence of distress lung syndrome; septic shock; mortality.
Clinical and Immunomorphological Features of Liver Damage in Severe Preeclampsia
Authors: Sidorova Iraida S. , Nikitina Natalya A. , Ageev Mikhail B. , Kokin Albert A.
Published: December 2020

Background.Liver diseases associated with pregnancy are recorded in 0.73% of pregnant women, often accompanied by the development of hepatic dysfunction/insufficiency, and are the cause of increased morbidity and mortality in both mother and child. A pathomorphological study helps to understand the pathophysiology of severe liver damage in preeclampsia, and to optimize the management of such patients.Aims to study the clinical, morphological and immunohistochemical features of liver tissue lesions in the most severe forms of preeclampsia and eclampsia, which ended in death.Methods.Autopsy material analysis of 10 patients who died from preeclampsia, eclampsia and their complications (main group) and 3 patients who died from other causes (comparison group). Pathomorphological and immunohistochemical studies of organs and tissues (in particular, liver tissue) were performed using a marker of neurons and neuroendocrine cells -NSE and a marker of endotheliocytes CD-34.Results.An immunohistochemical study with a CD-34 endotheliocyte marker in the main group revealed a vascularization deficiency in the 2nd and 3rd zone of hepatic acini, there were also foci of necrosis. Such changes indicate deep and prolonged hypoperfusion. The use of the NSE marker in the group of patients who died from preeclampsia/eclampsia revealed a sharp increase in Kupffer cells in the first and second zones of acini with pronounced immunoexpression of NSE in the nuclei and cytoplasm of these cells, which indicates severe hepatic dysfunction (in particular, impaired detoxification and elimination functions of the liver). At the same time, only 3 out of 10 women in the main group are clinically registered with HELLP syndrome, while the rest had signs of multiple organ (including acute liver) failure.Conclusions.The clinical symptoms of liver damage, including those with severe preeclampsia, arise, as a rule, already against the background of severe morphological changes in its tissue and, as a rule, indicate functional decompensation. Liver immunology remains little studied, which requires further research on this problem.
Mechanisms of Arrhythmogenesis and Risk Factors for Thromboembolic Events in Patients with Atrial Fibrillation without Concomitant Coronary and Valvular Heart Disease
Authors: Golukhova Elena Z. , Gromova Olga I. , Bulaeva Naida I. , Arakelyan Mari G.
Published: December 2020

Aimsidentification the correlates between parameters of tissue Doppler imaging, EF thickness by MRI and biochemical markers of fibrosis and inflammation in patients with nonvalvular AF. Retrospectively to evaluate clinical and instrumental parameters influencing the development of thromboembolic events.Methods.Data analysis was performed on 151 patients with different type of AF. A retrospective analysis included 112patients. 15 (13%) had a history of LAA thrombosis and/or thromboembolic events (stroke, TIA). The prospective analysis included 39patients. We identified groups with idiopathic AF (N = 21), AF with arterial hypertension (N = 18). And also a group with normal or slightly enlarged (4.5 sm) LA s (N = 29), and with LA 4.5 sm (N = 10). Echocardiography with tissue Doppler imaginе and cardiac MRI were performed. The level of: matrix metalloproteinases (MMP-2, MMP-9), tissue inhibitor of matrix metalloproteinase-1 (TIMP-1), transforming growth factor beta-1 (TGF beta-1), soluble intercellular adhesion molecule (sICAM) was assessed.Results.The following parameters were significantly associated with LA thrombosis and thromboembolic events: age over 50 years (p = 0.001), obesity (p = 0.036), persistent AF (p = 0.003), the phenomenon of spontaneous ECHO contrast in LA (p = 0.03), the blood flow velocity in the LAA less than 30 sm / s (p = 0.005), morphological type III of LAA (p = 0.012). The greatest correlation between the thickness of the EFT and biomarkers was observed relative to: MMP-9 ( =0.65; Tcr= 0.16), TIMP-1 ( = 0.71; Tcr= 0.18) in the group of idiopathic AF; and TGF-beta1 ( = 0.22; Tcr= 0.19) in the general group. The percentage of left atrial myocardial fibrosis was correlated with TIMP-1 levels. There was a correlation between E/e and MMP-9, TIMP-1 in patients with idiopathic AF ( = 0.65; Tcr= 0.16 and = 0.56; Tcr= 0.21 respectively).Conclusion.The increasing levels of MMP-9 and TIMP-1 are associated with epicardial fat thickness by MRI. In addition to CHA2DS2VASc scale, we identified novel predictors of LA thrombosis and/or thromboembolic events, which are: chronic type AF, low LAA blood flow velocity, the phenomenon of spontaneous ECHO contrast in LA and the morphological LAA type III by CT.
Feeder-Free Cell Culture of Labial Oral Mucosal Epithelium for Tissue-Engineering and Regenerative Medicine
Authors: Borzenok Sergey A. , Malyugin Boris E. , Gerasimov Maxim Y. , Ostrovskiy Dmitriy S. , Shatskikh Anna V.
Published: December 2020

Background.The cultured cheek mucosa epithelium (buccal epithelium, BE) is used for autologous transplants generation and tissue engineering. An alternative source of cells for these purposes may be the lip mucosa, covered, like BE, with non-keratinized stratified squamous epithelium, but with some histological distinctions.Aims to characterize the human lip mucosa as a promising source of epithelial cells for autologous transplantation and tissue engineering.Methods.Scrapings of the lip, cheek, and gum mucosa from five healthy volunteers were analyzed by cytofluorimetry to determine the level of desquamation and cytokeratin (CK) 10 and 13 expression. The lip mucosa of two patients was characterized using routine histological staining and fluorescence immunohistochemistry for CK 3, 4, 10, 13, and p63 marker. 35 samples of full-thickness strips of the patients lip mucosa were used to set the explant (n=18) and enzymatic (n=17) techniques for expansion epithelium. Culture systems with 1.05 and 0.06mM Calcium contained 5% fetal bovine serum, 5 g/ml human insulin, 5 g/ml hydrocortisone, 10 ng/ml human epidermal growth factor. Stable cultures were stained for p63, vimentin, zonula occludens-1 (ZO-1), and CK10. Software tools determined levels of their expression.Results.The number of cells in the lip and gum samples was significantly lower than from the cheek. The median number of CK13 positive cells was significantly different for the gum (6.4%) and cheek (64.8%, p=0.0089). Significant differences for CK10 positive cells were not observed. The epithelium of the lip mucosa was 72.13.6 m thick, relatively flat, and without keratinization sites. Samples were positively stained for CK 4 and 13, in the absence of expression of CK 3 and 10. The primary culture of epithelial cells obtained by explant technique was significantly more effective (p=0.001) in comparison with the enzymatic method. Stable cultures had a cobble-stone morphology in both culture systems. The levels of vimentin and p63 expression in both culture systems was not significantly differ. ZO-1 expression was 3.6-fold higher for 1.05-mMCa++medium (p=0.0006).Conclusions.Epithelium cell culture from the lip mucosa can be obtained by culturing explants without a feeder layer. Quality control steps have been developed for cultured cells and biopsy site.
Cytokine Levels of Skin Lesions in Moderate and Severe Psoriasis as Predictors for the Type 4 Fosphodiesterase Inhibitor (Apremilast) Therapy Effectivness
Authors: Kubanov Alexey A. , Artamonova Olga G. , Karamova Arfenya E. , Vasileva Elena L. , Deryabin Dmitry G.
Published: December 2020

Background.Psoriasis is a widespread skin disorder characterized by cytokines as the main modulators of skin inflammation. A promising psoriasis therapy approach is targeted on cytokine networks by inhibiting the phosphodiesterase 4 (PDE-4). The efficacy and safety of the PDE-4 inhibitor apremilast in psoriasis confirmed in multicenter controlled studies, which, however, are accompanied by reports of unsuccessful therapy cases.Aims to determine early immunological predictors for PDE-4 inhibitor (apremilast) therapy efficacy based on skin lesions cytokines analyzes in patients with moderate to severe psoriasis.Methods.An open, uncontrolled prospective clinical study was performed. Efficacy of apremilast was analyzed by PASI, BSA, sPGA and DLQI. The outcomes at 26 therapy week were compared with the cytokine levels in skin biopsies selected before starting therapy and analyzed using xMAP technology. The multiparameter prognostic model for apremilast therapy effectiveness was developed based on a heterogeneous sequential recognition procedure.Results.The 34 patients with moderate to severe psoriasis were included in the study. According to the clinical outcomes, two comparison groups were formed: high (75% reduction in PASI score or more; n=14) and insufficient (50% reduction in PASI score or less; n=20) apremilast efficiency. Cytokines analyses showed an inverse relationship between the initial anti-inflammatory IL-10 level and the PASI reduction (r=0.37; p0.025). On the other hand, the relationships between pro-inflammatory cytokines IL-1 and IL-6 levels and PASI score at the 26th week of therapy were characterized by positive correlation: r=0.31 (p0.05) and r=0.37 (p0.025), respectively. Based on the data obtained, a predictive model for the apremilast therapy efficiency was developed. The expected predictive values of this model were 86% for a high therapy effectiveness and 60% for an insufficient effectiveness, respectively.Conclusions.The study results for the first time describe the cytokine profiles in the skin lesions in patients, who responded differently to PDE-4 inhibitor therapy. These dada allows to predict the treatment efficacy and give a chance to personalize apremilast usage for the moderate and severe psoriasis treatment.
Molecular Markers in Occupational Chronic Obstructive Pulmonary Disease Comorbid with Heart Failure
Authors: Shpagina Lyubov A. , Kamneva Natal’ya V. , Shpagin Ilya Semenovich , Kotova Olga S. , Anikina Ekaterina V. , Gerasimenko Dmitrij A.
Published: December 2020

Background.Comorbid heart failure (HF) is common in chronic obstructive pulmonary disease (COPD). Comorbid condition features are studied well in COPD due to tobacco smoke. There is a lack of data about mechanisms, clinical and functional specificity of occupational COPD and HF comorbidity. As occupational COPD and HF share common symptoms and sometimes lung function disorders, there is an unmet need in new markers of HF in occupational COPD.Aims to establish molecular markers associated with occupational COPD with HF comorbidity.Methods.Subjects with occupational COPD were enrolled in a single-center prospective cohort observational study. Comparison group COPD due to tobacco smoke. Then groups were stratified according to HF so the following subgroups were compared: occupational COPD with HF (n=63), occupational COPD without HF (n=52), COPD due to tobacco smoke with HF (n=41), COPD due to tobacco smoke without HF (n=74). Control group healthy people (n=115). Groups were matched by demographics, duration of COPD and HF. CODP was diagnosed according to GOLD 20112020 criteria, HF according to Russian Federal clinical guidelines. Occupational etiological factors were silica dust, organic solvents, metal fumes. Clinical and functional characteristics of CODP and HF were obtained. Serum levels of pulmonary and activation-regulated chemokine (PARC/CCL-18), protein S100, troponin, N terminal pro brain natriuretic peptide (NT-pro-BNP), von Willebrand factor, C-reactive protein were measured by enzyme linked immunosorbent assay, fibrinogen were measured by Clauss method, lactate dehydrogenase, creatine phosphokinase, alanine aminotransferase, aspartate aminotransferase were measured by standard biochemical method. Data are presented as median and interquartile range. Linear regression were used to explore relationships.Results.The molecular specificity of occupational COPD comorbid with HF were the largest increase in serum concentration of PARC-CCL18, NT-pro-BNP, protein S100, troponin, von Willebrand factor and fibrinogen. This factors were associated with length of service. For PARC-CCL18 В=1.1; for NT-pro-BNP В=0.9; for protein S100 В=1.3; for troponin В=0.8, for von Willebrand factor В=1.5 and for fibrinogen В=1.1. Molecular factors also were related to phenotype characteristics of COPD and HF. In multiply regression model the best predictors of comorbidity of CODP and HF were PARC-CCL18 (В=1.1; р=0.002), NT-pro-BNP (В=1.5; р=0.001), protein S100 (В=1.2; р=0.002), troponin (В=0.9; р=0.003). The model was adjusted for gender, age, duration of CODP and HF, FEV1.Conclusions.Occupational CODP comorbid with heart failure is the distinct phenotype. The perspective molecular markers of this phenotype are serum levels of PARC-CCL18, NT-pro-BNP, protein S100, troponin.
Effect of Anesthesia in the Ante- and Intranatal Periods of Development on the Cognitive Status of Children Aged from 0 to 3 Years
Authors: Aleksandrovich Yury S. , Gorkovaya Irina A. , Miklyaeva Anastasia V.
Published: December 2020

The article presents the results of a systematic review of publications aimed at analizing the effects of anesthesia during ante- and intranatal periods of development on the cognitive status of infants and young children. The search for publications was carried out by analyzing electronic bibliographic databases Web of Science and PubMed. The analysis revealed five factors, which determine the effects of ante- and intranatal anesthesia on the cognitive development of children: the type of anesthesia, the type of anesthetic, the period of childs development, the frequency and duration of exposure as well as the dosage and concentration of the substance. Such cognitive functions as memory, learning ability, speech, perceptual processes and motor activity as a predictor for intelligence formation in early childhood are the most vulnerable to the effects of ante- and intranatal anesthesia. The analysis led to the conclusion that regional anesthesia is the safest option of analgesia for operative delivery and non-surgical operations in pregnant women (in terms of the risks of neurocognitive development disorders in children). In the case of general anesthesia, the lowest risks of negative consequences for cognitive status of a child during early childhood are associated with the exposure of sevoflurane.
The Results of the Use of Angiotensin Receptor Inhibitors and Neprilisin in Secondary Functional Mitral Regurgitation in Outpatient Practice
Authors: Ryazanov Alexey S. , Kapitonov Konstantin I. , Makarovskaya Mariya V. , Kudryavtsev Alexey A.
Published: December 2020

Background. Morbidity and mortality in patients with functional mitral regurgitation (FMR) remains high, however, no pharmacological therapy has been proven to be effective.Aimsto study the effect of sacubitrile/valsartan and valsartan on functional mitral regurgitation in chronic heart failure.Methods.This double-blind study randomly assigned sacubitrile/valsartan or valsartan in addition to standard drug therapy for heart failure among 100 patients with heart failure with chronic FMR (secondary to left ventricular (LV) dysfunction). The primary endpoint was a change in the effective area of the regurgitation hole during the 12-month follow-up. Secondary endpoints included changes in the volume of regurgitation, the final systolic volume of the left ventricle, the final diastolic volume of the left ventricle, and the area of incomplete closure of the mitral valves.Results.The decrease in the effective area of the regurgitation hole was significantly more pronounced in the sacubitrile/valsartan group than in the valsartan group (0.070.066against0.030.058sm2; p=0.018)in the treatment efficacy analysis, which included 100patients (100%). The regurgitation volume also significantly decreased in the sacubitrile/valsartan group compared to the valsartan group (mean difference:8.4ml; 95%CI, from 13.2 until 1.9;р=0.21). There were no significant differences between the groups regarding changes in the area ofincomplete closure of the mitral valves and LV volumes, with the exception of the index of the final LV diastolic volume (p=0.07).Conclusion.Among patients with secondary FMR, sacubitril/valsartan reduced MR more than valsartan. Thus, angiotensin receptor inhibitors and neprilysin can be considered for optimal drug treatment of patients with heart failure and FMR.
OPEN PACKING NUMBER FOR SOME CLASSES OF PERFECT GRAPHS
Authors: Chandrasekar K. Raja , Saravanakumar S.
Published: December 2020

Let \(G\) be a graph with the vertex set \(V(G)\).  A subset \(S\) of \(V(G)\) is an open packing set of \(G\) if every pair of vertices in \(S\) has no common neighbor in \(G.\)  The maximum cardinality of an open packing set of \(G\) is the open packing number of \(G\) and it is denoted by \(\rho^o(G)\).  In this paper, the exact values of the open packing numbers for some classes of perfect graphs, such as split graphs, \(\{P_4, C_4\}\)-free graphs, the complement of a bipartite graph, the trestled graph of a perfect graph are obtained.
ON ROUTING PROBLEM WITH STARTING POINT OPTIMIZATION
Authors: Chentsov Alexander G. , Chentsov Pavel A.
Published: December 2020

One problem focused on engineering applications is considered. It is assumed that sequential visits to megacities have been implemented. After all visits have been made, it is required to return to the starting point (a more complex dependence on the starting point is also considered). But the last requirement is not strict: some weakening of the return condition is acceptable. Under these assumptions, it is required to optimize the choice of starting point, route, and specific trajectory. The well-known dynamic programming (DP) is used for the solution. But when using DP, significant difficulties arise associated with the dependence of the terminal component of the criterion on the starting point. Starting point enumeration is required. We consider the possibility of reducing the enumeration associated with applied variants of universal (relative to the starting point) dynamic programming. Of course, this approach requires some transformation of the problem.
DISTANCE-REGULAR GRAPH WITH INTERSECTION ARRAY {27, 20, 7; 1, 4, 21} DOES NOT EXIST
Authors: Efimov Konstantin S. , Makhnev Alexander A.
Published: December 2020

In the class of distance-regular graphs of diameter 3 there are 5 intersection arrays of graphs with at most 28 vertices and noninteger eigenvalue. These arrays are \(\{18,14,5;1,2,14\}\), \(\{18,15,9;1,1,10\}\), \(\{21,16,10;1,2,12\}\), \(\{24,21,3;1,3,18\}\), and \(\{27,20,7;1,4,21\}\). Automorphisms of graphs with intersection arrays \(\{18,15,9;1,1,10\}\) and \(\{24,21,3;1,3,18\}\) were found earlier by A.A. Makhnev and D.V. Paduchikh. In this paper, it is proved that a graph with the intersection array \(\{27,20,7;1,4,21\}\) does not exist.
POSITIONAL IMPULSE AND DISCONTINUOUS CONTROLS FOR DIFFERENTIAL INCLUSION
Authors: Finogenko Ivan A. , Sesekin Alexander N.
Published: December 2020

Nonlinear control systems presented in the form of differential inclusions with impulse or discontinuous positional controls are investigated. The formalization of the impulse-sliding regime is carried out. In terms of the jump function of the impulse control, the differential inclusion is written for the ideal impulse-sliding regime. The method of equivalent control for differential inclusion with discontinuous positional controls is used to solve the question of the existence of a discontinuous system for which the ideal impulse-sliding regime is the usual sliding regime. The possibility of the combined use of the impulse-sliding and sliding regimes as control actions in those situations when there are not enough control resources for the latter is discussed.
SOME NOTES ABOUT THE MARTINGALE REPRESENTATION THEOREM AND THEIR APPLICATIONS
Authors: Habibi Reza
Published: December 2020

An important theorem in stochastic finance field is the martingale representation theorem. It is useful in the stage of making hedging strategies (such as cross hedging and replicating hedge) in the presence of different assets with different stochastic dynamics models. In the current paper, some new theoretical results about this theorem including derivation of serial correlation function of a martingale process and its conditional expectations approximation are proposed. Applications in optimal hedge ratio and financial derivative pricing are presented and sensitivity analyses are studied. Throughout theoretical results, simulation-based results are also proposed. Two real data sets are analyzed and concluding remarks are given. Finally, a conclusion section is given.
INEQUALITIES FOR ALGEBRAIC POLYNOMIALS ON AN ELLIPSE
Authors: Nikiforova Tatiana M.
Published: December 2020

The paper presents new solutions to two classical problems of approximation theory. The first problem is to find the polynomial that deviates least from zero on an ellipse. The second one is to find the exact upper bound of the uniform norm on an ellipse with foci \(\pm 1\) of the derivative of an algebraic polynomial with real coefficients normalized on the segment \([- 1,1]\).
THE LOCAL DENSITY AND THE LOCAL WEAK DENSITY IN THE SPACE OF PERMUTATION DEGREE AND IN HATTORI SPACE
Authors: Yuldashev Tursun K. , Mukhamadiev Farhod G.
Published: December 2020

In this paper, the local density \((l d)\) and the local weak density \((l w d)\) in the space of permutation degree as well as the cardinal and topological properties of Hattori spaces are studied. In other words, we study the properties of the functor of permutation degree \(S P^{n}\) and the subfunctor of permutation degree \(S P_{G}^{n}\),  \(P\) is the cardinal number of topological spaces. Let \(X\) be an infinite \(T_{1}\)-space. We prove that the following propositions hold.(1) Let \(Y^{n} \subset X^{n}\); (A) if \(d\, \left(Y^{n} \right)=d\, \left(X^{n} \right)\), then \(d\, \left(S P^{n} Y\right)=d\, \left(SP^{n} X\right)\); (B) if \(l w d\, \left(Y^{n} \right)=l w d\, \left(X^{n} \right)\), then \(l w d\, \left(S P^{n} Y\right)=l w d\, \left(S P^{n} X\right)\). (2) Let \(Y\subset X\); (A) if \(l d \,(Y)=l d \,(X)\), then \(l d\, \left(S P^{n} Y\right)=l d\, \left(S P^{n} X\right)\); (B) if \(w d \,(Y)=w d \,(X)\), then \(w d\, \left(S P^{n} Y\right)=w d\, \left(S P^{n} X\right)\).(3) Let \(n\) be a positive integer, and let \(G\) be a subgroup of the permutation group \(S_{n}\). If \(X\) is a locally compact \(T_{1}\)-space, then \(S P^{n} X, \, S P_{G}^{n} X\), and \(\exp _{n} X\) are \(k\)-spaces.(4) Let \(n\) be a positive integer, and let \(G\) be a subgroup of the permutation group \(S_{n}\). If \(X\) is an infinite \(T_{1}\)-space, then \(n \,\pi \,w \left(X\right)=n \, \pi \,w \left(S P^{n} X \right)=n \,\pi \,w \left(S P_{G}^{n} X \right)=n \,\pi \,w \left(\exp _{n} X \right)\).We also have studied that the functors \(SP^{n},\) \(SP_{G}^{n} ,\) and \(\exp _{n} \) preserve any \(k\)-space. The functors \(SP^{2}\) and \(SP_{G}^{3}\) do not preserve Hattori spaces on the real line. Besides, it is proved that the density of an infinite \(T_{1}\)-space \(X\) coincides with the densities of the spaces \(X^{n}\), \(\,S P^{n} X\), and \(\exp _{n} X\). It is also shown that the weak density of an infinite \(T_{1}\)-space \(X\) coincides with the weak densities of the spaces \(X^{n}\), \(\,S P^{n} X\), and \(\exp _{n} X\).
THE VARIETY GENERATED BY AN AI-SEMIRING OF ORDER THREE
Authors: Zhao Xianzhong , Ren Miaomiao , Crvenković Siniša , Shao Yong , Dapić Petar
Published: December 2020

Up to isomorphism, there are 61 ai-semirings of order three. The finite basis problem for these semirings is investigated. This problem for 45 semirings of them is answered by some results in the literature. The remaining semirings are studied using equational logic. It is shown that with the possible exception of the semiring \(S_7\), all ai-semirings of order three are finitely based.
Tradução e adaptação transcultural do Patient Perception of Integrated Care Survey para avaliação da integração dos cuidados no Brasil
Authors: Vieira Ed Wilson Rodrigues , Cerqueira Lana Jaya Silveira , Silva Sobrinho George , Gazzinelli Andréa
Published: December 2020

O aumento no número de estratégias, em todo o mundo, para melhorar a integração da atenção à saúde de pessoas portadoras de condições crônicas determina a necessidade de instrumentos de avaliação da integração aplicáveis a diferentes contextos culturais. Assim, o objetivo deste artigo é divulgar a tradução e a adaptação transcultural do Patient Perception of Integrated Care Survey - version 2.1 (PPIC Survey) para a avaliação da integração dos cuidados a portadores de condições crônicas no Brasil. Trata-se de um estudo de desenvolvimento metodológico no qual foram utilizadas recomendações internacionais para tradução e adaptação de questionários, incluindo, sequencialmente, técnicas de equivalência – (1) tradução inicial para o português brasileiro, (2) painel de especialistas para obter consenso sobre a tradução e (3) tradução reversa para o inglês – e de contextualização (avaliação cognitiva com a população alvo). A tradução, o consenso entre especialistas e a tradução reversa garantiram a equivalência da versão brasileira à versão original em inglês. A avaliação cognitiva indicou, ao final, uma boa compreensão das perguntas pela população alvo. Apesar de nenhuma das 60 questões estruturadas ter tido a necessidade de ser retirada, mais da metade demandaram cuidados maiores para a adaptação, necessitando ser redigidas (34) ou substancialmente modificadas (2). Dessa forma, a tradução e a adaptação transcultural do PPIC Survey para o idioma português brasileiro foi bem sucedida, sendo a versão brasileira denominada Questionário sobre a Percepção dos Pacientes quanto à Integração dos Cuidados – Versão 1.0 (PPIC-Brasil-1.0).
AMBIENTE DE ENSINO-APRENDIZAGEM NA FORMAÇÃO INICIAL UNIVERSITÁRIA DE EDUCAÇÃO FÍSICA
Authors: Cardoso Allana Alexandre , Ciampolini Vitor , Silva Jaqueline da , Salles William das Neves , Moura William Alexander Marchetti , Nascimento Juarez Vieira do
Published: December 2020

Objetivou-se, neste estudo, analisar as percepções de estudantes universitários de Educação Física em distintos níveis de progressão no curso, sobre o ambiente de ensino-aprendizagem na formação inicial. Participaram 273 estudantes (Bacharelado n=150; Licenciatura n=123) do curso de licenciatura em Educação Física de uma universidade pública de Santa Catarina, Brasil, os quais responderam à versão adaptada do Questionário de Avaliação do Ambiente Percebido da Formação Inicial em Educação Física. O teste Qui-quadrado foi utilizado para analisar as associações entre o nível de progressão discente nos cursos e suas percepções sobre o ambiente de formação inicial. Os resultados indicaram a predominância de aulas/vivências práticas e de avaliações teóricas escritas, especialmente nas fases iniciais. As experiências poucos frequentes de observação, e o aprendizado pela prática ou por observação foi o papel assumido, especialmente evidenciados nos semestres finais. Apesar de os estudantes terem se percebido ativos quanto ao seu nível de participação, indicaram que os professores são os principais responsáveis por tomar as decisões. Conclui-se que a formação inicial em Educação Física necessita reconfigurar determinadas práticas de ensino-aprendizagem para aumentar o envolvimento e a responsabilidade discentes pelo próprio processo formativo.
EL GOBIERNO CIVIL DE LA PARTICIPACIÓN EN COTACACHI ANTES Y DURANTE LA CONSTITUCIÓN DE 2008
Authors: Morales César Gonzalo Alvear
Published: December 2020

El presente trabajo analiza la apropiación del proceso participativo de Cotacachi por los actores locales que implementaron un gobierno civil de participación en el cantón, y cómo revalidaron su legitimidad ante la institucionalización determinada por la Constitución de 2008. Mediante este estudio se pretende aportar elementos para la comprensión y la discusión del actual momento de la participación, además de visibilizar las posibilidades de acción política de los espacios de participación. El objetivo planteado apunta a describir el proceso de construcción del gobierno civil participativo en Cotacachi por los actores sociales del cantón, antes y durante la Constitución de 2008. Metodológicamente se realizó una revisión documental y bibliográfica que, de manera cronológico-descriptiva analiza el desarrollo de capacidades políticas y participativas de los actores sociales con las que enfrentaron los cambios constitucionales, manteniendo la autonomía y la estructura original de su proceso participativo y logrando su reconocimiento legal como sistema participación cantonal. El resultado señala al gobierno civil de la participación como efecto del proceso histórico de lucha y organización social, mediante el cual los actores sociales acumularon destrezas, conocimientos, experiencia y recursos políticos que los convirtieron en autoridad no estatal de la participación.
Mani Yazısındaki ḫ (x veya χ), f ve v (β) Seslerini Karşılayan İşaretlerin Manihaist Eski Uygur ve Orta İran Metinlerindeki Yazım Özellikleri
Authors: ÖZBAY Betül
Published: December 2020

Eski Uygurlar Manihaizm dinini öğrendikleri halk olan Soğdlardan pek çok yönden

etkilenmişlerdir. Manihaist Soğdlu rahiplerden öğrendikleri Mani yazısı da bu etkileşim

unsurlarından bir tanesidir. Manihaist Uygurlar özellikle dinî metinlerde tıpkı diğer Manihaist

topluluklar gibi Mani yazısını yaygın olarak kullanmışlardır. Turfan yazmaları

arasında Eski Uygurca ve Soğdcanın yanı sıra Partça, Orta Farsça gibi diğer bazı Orta

İran dillerinde de Mani yazısıyla yazılmış metinler mevcuttur. Bu çalışmada, Mani yazısının

temel yirmi üç harfi içinde yer almayan, diğer harflerden ikincil olarak geliştirilen

ötümsüz, sızıcı, küçük dil ünsüzü ḫ (x veya χ); ötümsüz, sızıcı, diş dudaksıl f ve ötümlü,

sızıcı, diş dudaksıl v (β) seslerini gösteren yazı işaretlerinin Manihaist Eski Uygur ve

Soğdca, Partça ile Orta Farsça metinlerdeki yazım özellikleri incelenmiş; tespit edilen

örnekler karşılaştırmalı olarak sunulmuştur. Ayrıca, Mani yazısı, yazının tarihî gelişimi

ve yazıyı kullanan halklardan kısaca bahsedilmiştir.
Predicting Life Satisfaction: Self-Efficacy and Cynical Attitudes
Authors: BULUT Meryem Berrin
Published: December 2020

This study aimed to investigate the effect of self-efficacy and cynical attitudes on life

satisfaction. Participants, including 330 college students of whom 66.97% were women

in the 18-36 age range (M = 21.20, SD = 1.91), from different academic departments and

class levels of a state university in Middle Anatolia, completed the Self-Efficacy Scale,

the Cynical Attitudes Towards University Scale, the Life Satisfaction Scale and the personal

information form. In data analysis, correlation and regression analysis were utilized.

The correlation analysis indicated significant relations between self-efficacy, cynical attitudes

towards university, and life satisfaction. Self-efficacy and cynical attitudes towards

university explained 17% of the variance in life satisfaction. The results were discussed in

the light of information obtained from related literature and some suggestions for further

studies were provided.
URBAN SPRAWL IN NİZİP CITY: ASSESSING WITH REMOTELY SENSED AND POPULATION DATA
Authors: SUNBUL Fatih
Published: December 2020

Based on Remote Sensing image processing and Geographic Information Systems analysis, population-dependent urban structures can be accurately monitored, analysed, and potential spatial or environmental problems restrained by professional land use management. In this study, the city of Nizip, located within the province of Gaziantep, was evaluated in this perspective and its development in the last thirty years was determined. The satellite images of 1990 and 2019 were evaluated within the framework of CORINE land classification system. The controlled classification method was implemented in the analysis and the city's growth rate and direction were determined while land cover changes were investigated both statistically and spatially. According to the analysis, residential areas in the study area, which were 555 ha in 1990, exceeded 1000 ha in 2019, due to industrialization and population growth. Urban sprawl was observed in NE and E directions. In addition, the bare lands of the city have been converted to dry agricultural lands in the last three decades which is supposedly due to long term climate effects. Along with the increasing industrialization movement in this period, the population increased by 30% on average in the central neighbourhoods. Migration from evacuated villages to the city centre following dam construction and water impoundment phases has increased the population. Rapid urbanization is also observed alongside newly built highways and motorways. Regarding increasing population movements in recent years, it is predicted that there could be spatial and environmental problems due to rapid and unplanned urbanization in Nizip city. It is stated that the elimination of these problems can be carried out through accurate and planned land use decision support systems.
A Multidisciplinaridade Entre Direito e Psicologia na Repressão de Atos Infracionais: Um Estudo Teórico do Caso “Champinha”
Authors: De Vargas Fernanda , Dos Santos Welter Lisiane , Thais Steffler Hellin , Corrêa da Silva Henrique
Published: December 2020

Os casos de adolescentes envolvidos em delitos tem sido noticiado constantemente, além de ter se configurado como um grave problema social brasileiro. Para dar conta dessa problemática, o Direito busca o diálogo com outras áreas. Essa comunicação multidisciplinar já perpassou antigos embates teóricos em relação a adolescentes em conflito com a lei. Desse modo, o presente artigo objetiva discutir como o Sistema de Justiça se apoiou na Psiquiatria e na Psicologia para a subsidiar a decisão judicial no emblemático caso “Champinha”. O presente artigo caracteriza-se como uma revisão narrativa. Para a coleta de dados foram realizadas pesquisas em fontes primárias, além de pesquisas em bibliografias científicas que abordassem a temática. Os dados apontam que a partirde laudos médicos e psiquiátricos emitidos, as medidas tomadas pela Justiçaviolaram os direitos fundamentais do adolescente, visto que foi deferida a interdição civil cumulada com internação hospitalar compulsória de Champinha.Conclui-se assim, que embora,no século XX tenham ocorrido avanços nas garantias e direitos de crianças e adolescentes, o caso apresentado evidencia o quanto ainda, o Estado, baseando-se no saber médico e psicológico pode tomar decisões que violam os direitos fundamentais de adolescentes em conflito com a lei.
Correlation of Handprints and Footprints with respect to Stature: Study on Maharashtrians of Mumbai
Authors: Bhandari Deepika , Patil Sonali , Sahajpal Vivek
Published: December 2020

Identification of an individual is an important aspect in forensic investigations. Stature estimation is of interest to forensic scientists for its importance in human identification. The present study was an attempt to deduce the stature from footprints as well as the hand prints and hence to determine whether there is any correlation between the stature and the respective prints/ length.  Footprint is valuable physical evidence that can be found at scene of crime and its identification can facilitate elimination of the suspects and establishing the identity of the criminal. Also handprints to some extent can help in estimation of stature. The study aimed to estimate the stature in a sample of 1000 bilateral footprints and handprints collected from 500 adult Indian male Maharashtrians and 500 adult Indian female Maharashtrians from Mumbai who consented to volunteer in the study and ranged in the age-group of 18 to 25 years. Samples were collected and data was entered in Microsoft Excel 2007 and statistically analyzed using linear regression analysis. In case of both males and females all footprint lengths exhibit a statistically positive significant correlation with stature. Similarly, handprint lengths exhibit a statistically positive significant correlation with stature. The values of correlation co-efficient shows that the footprint length is more significantly correlated with stature compare to handprint lengths.
Diagnóstico comunitario ante desastres climáticos: Una experiencia de aprendizaje-servicio
Authors: Sandoval-Diaz José , Cuadra-Martínez David , Orellana-Fonseca Cristian , Sandoval-Obando Eduardo
Published: December 2020

El incremento de eventos extremos —a causa del cambio climático— conlleva no solo a la necesidad local de fortalecer las capacidades de afrontamiento y de resiliencia a nivel comunitario, sino también, al replanteo sobre la idoneidad de los planes formativos universitarios en el desarrollo de profesionales competentes ante estos nuevos riesgos emergentes. Bajo este contexto, el presente trabajo tuvo como objetivo valorar la implementación de un proceso de diagnóstico de necesidades comunitarias ante un desastre climático, esto mediante la aplicación metodológica de la estrategia de aprendizaje-servicio (ApS) en un curso de estudiantes de psicología en Chile. Para esto seleccionamos un estudio de caso representativo de gestión comunitaria ante un desastre climático en el norte de Chile, esto bajo un diseño de investigación acción-participativa (IAP). Los datos son producidos mediante la triangulación intermétodo de seis técnicas, esquematizando los resultados del proceso de aprendizaje en cuatro áreas: i) teórico-conceptual, ii) metodológica, iii) práctica y iv) ético-política. Los resultados relevan el uso de ApS en el proceso de enseñanza-aprendizaje del diagnóstico comunitario, identificando tanto ventajas como limitaciones en el desarrollo de competencias disciplinares, transversales profesionales y del servicio entregado.  Se concluye con la importancia de integrar estrategias horizontales, participativas y situadas en los procesos de enseñanza profesional, esto acorde al tipo de formación universitaria integral que requiere la problemática psicosocial compleja del cambio climático
Metodología de aprendizaje-servicio en un proyecto integrado de costos y marketing
Authors: Ganga-Contreras Francisco , Rodríguez-Quezada Estela , Guiñez-Cabrera Nataly
Published: December 2020

La formación de profesionales competentes, con visión y sello de compromiso con la sociedad, debe irmás allá de los procesos tradicionales de enseñanza, resultando entonces la innovación un factor clave. El aprendizaje-servicio (ApS) es una metodología que integra la enseñanza con el servicio comunitario de los estudiantes en un entorno real. Existen varios desafíos en la implementación de esta metodología activa, teniendo en cuenta las partes interesadas y las necesidades de la comunidad. En este sentido, este estudio busca describir la experiencia en cuanto al diseño, la implementación y la gestión de la metodología de aprendizaje-servicio en un proyecto integrado que contempla dos asignaturas, costos y marketing, en un programa de negocios en una universidad estatal del centro-sur de Chile. El trabajo se sustenta en la sistematización de experiencia, basada en tres fases de implementación dentro de la comunidad:(1) planificación, diseño y análisis, (2) entrega del servicio y, (3) evaluación, reflexión y monitoreo del aprendizajeservicio. Las etapas de diseño, implementación y gestión de un proyecto de estas características podrían servir de guía y orientaciones en futuras experiencias por parte de los profesores o las instituciones que se encuentren interesados en la innovación de los procesos de la enseñanza-aprendizaje.
Aprendizaje Servicio en escuelas argentinas de Bachillerato Internacional
Authors: Mayer Liliana , Perozzo-Ramírez Wanda
Published: December 2020

El artículo analiza los modos en que se realizan proyectos de aprendizaje- servicio (AS) en el marco del Programa Diploma (PD) del Bachillerato Internacional (IB) en el área metropolitana de Buenos Aires, Argentina. A través de un estudio cualitativo, que combina entrevistas en profundidad a agentes institucionales, análisis documental y observaciones de clase en escuelas estatales y privadas, se indaga en los diversos sentidos de las actividades que estudiantes, docentes y directivos realizan para el componente CAS del PD. Los resultados del trabajo muestran conclusiones disímiles, cuando se trata de escuelas privadas asociadas a públicos de sectores medios y medios- altos, el AS aparece orientado a la acción o servicio social, destinado a mermar déficits de un tercero. Por el contrario, cuando se trata de escuelas estatales, donde los estudiantes tienen perfiles socioeconómicos más cercanos a los beneficiarios de las escuelas privadas, logran trascender dicha orientación para lograr bienes comunitarios, tangibles o intangibles. Este perfil desventajado es motivo en algunas instituciones estatales para cancelar proyectos de AS que trasciendan acciones solidarias puntuales y materiales. Del artículo se deduce la importancia de los agentes institucionales en la promoción de estos proyectos: si bien se trata de espacios donde los jóvenes son los protagonistas, el encuadre, habilitación o restricción para su realización dependerá de los adultos, de sus conocimientos, predisposición y valoración respecto del AS como pedagogía y práctica.
Investigación y aprendizaje: Retos en Latinoamérica hacia el 2030
Authors: Aldana-Zavala Julio Juvenal , Vallejo-Valdivieso Patricio Alfredo , Isea-Argüelles Josía
Published: December 2020

La educación ha tenido un giro epistémico en su accionar pedagógico, transcendiendo del modelo tradicional enfocado en el docente, hacia uno focalizado en el estudiante. En paralelo, la investigación se ha fomentadohacia nuevas vertientes metódicas, siendo un factor clave en el aprendizaje. Hoy día es esencial la fusión del aprendizaje e investigación con la función de generar conocimientos desde nuevos ángulos educativos. Además,la UNESCO y otros entes enfocados a la educación, han propuesto la conformación de un modelo educativo para aprender a lo largo de la vida. Es así que la presente investigación presenta los alcances en investigación y aprendizaje en Latinoamérica, para tal fin se planteó como objetivocentral: Analizar la investigación y aprendizaje como retos en Latinoamérica hacia el 2030, en este sentido se empleó una metodología descriptiva documental con un diseño bibliográfico, teniéndose como muestra poblacional, la revisión de 52 artículos de revistas indizadas en Scopus,Web of Science, Scielo, Redalyc, Latindex Catálogo 2.0. Esto con la finalidad de sistematizar propuestas de investigadores, identificándose factores pertinentes hacia la consecución de una educación transversal como medio para el logro de los ODS. Entre las conclusiones se tiene la necesidad de formar en una epistemología posibilitadora de una ecología de saberes en procura de contar con instituciones educativas, sostenibles y productivas comoeje medular de la sociedad global.