bluuebunny/crossref_metadata_2025 huggingface dataset:
Maximizing team synergy in AI-related interdisciplinary groups: an interdisciplinary-by-design iterative methodology
Authors: Bisconti Piercosma , Orsitto Davide , Fedorczyk Federica , Brau Fabio , Capasso Marianna , De Marinis Lorenzo , Eken Hüseyin , Merenda Federica , Forti Mirko , Pacini Marco , Schettini Claudia
Published: June 2022

In this paper, we propose a methodology to maximize the benefits of interdisciplinary cooperation in AI research groups. Firstly, we build the case for the importance of interdisciplinarity in research groups as the best means to tackle the social implications brought about by AI systems, against the backdrop of the EU Commission proposal for an Artificial Intelligence Act. As we are an interdisciplinary group, we address the multi-faceted implications of the mass-scale diffusion of AI-driven technologies. The result of our exercise lead us to postulate the necessity of a behavioural theory that standardizes the interaction process of interdisciplinary groups. In light of this, we conduct a review of the existing approaches to interdisciplinary research on AI appliances, leading to the development of methodologies like ethics-by-design and value-sensitive design, evaluating their strengths and weaknesses. We then put forth an iterative process theory hinging on a narrative approach consisting of four phases: (i) definition of the hypothesis space, (ii) building-up of a common lexicon, (iii) scenario-building, (iv) interdisciplinary self-assessment. Finally, we identify the most relevant fields of application for such a methodology and discuss possible case studies.
Intracellular Binding of Terfenadine Competes with Its Access to Pancreatic ß-cell ATP-Sensitive K+ Channels and Human ether-à-go-go-Related Gene Channels
Authors: Zünkler Bernd J. , Wos-Maganga Maria , Bohnet Stefanie , Kleinau Anne , Manns Detlef , Chatterjee Shivani
Published: June 2022

Most blockers of both hERG (human ether-à-go-go-related gene) channels and pancreatic ß-cell ATP-sensitive K+ (KATP) channels access their binding sites from the cytoplasmic side of the plasma membrane. It is unknown whether binding to intracellular components competes with binding of these substances to K+ channels. The whole-cell configuration of the patch-clamp technique, a laser-scanning confocal microscope, and fluorescence correlation spectroscopy (FCS) were used to study hERG channels expressed in HEK (human embryonic kidney) 293 cells and KATP channels from the clonal insulinoma cell line RINm5F. When applied via the pipette solution in the whole-cell configuration, terfenadine blocked both hERG and KATP currents with much lower potency than after application via the bath solution, which was not due to P-glycoprotein-mediated efflux of terfenadine. Such a difference was not observed with dofetilide and tolbutamide. 37–68% of hERG/EGFP (enhanced green-fluorescent protein) fusion proteins expressed in HEK 293 cells were slowly diffusible as determined by laser-scanning microscopy in the whole-cell configuration and by FCS in intact cells. Bath application of a green-fluorescent sulphonylurea derivative (Bodipy-glibenclamide) induced a diffuse fluorescence in the cytosol of RINm5F cells under whole-cell patch-clamp conditions. These observations demonstrate the presence of intracellular binding sites for hERG and KATP channel blockers not dialyzable by the patch-pipette solution. Intracellular binding of terfenadine was not influenced by a mutated hERG (Y652A) channel. In conclusion, substances with high lipophilicity are not freely diffusible inside the cell but steep concentration gradients might exist within the cell and in the sub-membrane space.

Graphical Abstract
On the infinitesimal generator of an optimal state semigroup
Authors: Acquistapace Paolo , Bucci Francesca
Published: June 2022

In this article we fully describe the domain of the infinitesimal generator of the optimal state semigroup which arises in the theory of the linear-quadratic problem for a specific class of boundary control systems. This represents an improvement over earlier work of the authors, joint with I. Lasiecka, where a set inclusion was established, but not an equality. The novel part of the proof of this result develops through appropriate asymptotic estimates that take advantage of the regularity analysis carried out in the study of the optimization problem, while the powers of positive operators and interpolation are still key tools. We also attest to the validity of an assumed relation between two significant parameters in the case of distinct systems of coupled hyperbolic–parabolic partial differential equations which are pertinent to the underlying framework.
The roles of DNA methylation on the promotor of the Epstein–Barr virus (EBV) gene and the genome in patients with EBV-associated diseases
Authors: Zhang Linlin , Wang Ran , Xie Zhengde
Published: June 2022

Epstein–Barr virus (EBV) is an oncogenic virus that is closely associated with several malignant and lymphoproliferative diseases. Studies have shown that the typical characteristic of EBV-associated diseases is aberrant methylation of viral DNA and the host genome. EBV gene methylation helps EBV escape from immune monitoring and persist in host cells. EBV controls viral gene promoter methylation by hijacking host epigenetic machinery to regulate the expression of viral genes. EBV proteins also interact with host epigenetic regulatory factors to mediate the methylation of the host’s important tumour suppressor gene promoters, thereby participating in the occurrence of tumorigenesis. Since epigenetic modifications, including DNA methylation, are reversible in nature, drugs that target DNA methylation can be developed for epigenetic therapy against EBV-associated tumours. Various methylation modes in the host and EBV genomes may also be of diagnostic and prognostic value. This review summarizes the regulatory roles of DNA methylation on the promotor of EBV gene and host genome in EBV-associated diseases, proposes the application prospect of DNA methylation in early clinical diagnosis and treatment, and provides insight into methylation-based strategies against EBV-associated diseases.

Key points

• Methylation of both the host and EBV genomes plays an important role in EBV-associateddiseases.

• The functions of methylation of the host and EBV genomes in the occurrence and development of EBV-associated diseases are diverse.

• Methylation may be a therapeutic target or biomarker in EBV-associated diseases.
Diagnostic Rechallenge with 18F‐FCH PET/CT Often Allows Minimally Invasive Parathyroidectomy While Maintaining Exceptional Cure Rates
Authors: Goren Shani , Paladino Nunzia Cinzia , Laks Shachar , Cuny Thomas , Vaillant‐Lombard Josiane , Mennetrey Clément , Assaf Dan , Hindié Elif , Guerin Carole , Fargette Christelle , Taïeb David , Sebag Fréderic
Published: June 2022

Background

Minimally invasive parathyroidectomy (MIP) has gained acceptance as the preferred surgical procedure for management of primary hyperparathyroidism (pHPT). Appropriate selection of patients for a MIP is a crucial step in its utilization. The aim of the study was to evaluate the role of 18F‐FCH PET/CT as second‐line imaging for accurately directing MIP.

Methods

This is a retrospective single‐center study. Seventy‐two patients with biochemical evidence of pHPT and a non‐conclusive or negative first‐line imaging (ultrasound and dual isotope subtraction scintigraphy) received 18F‐FCH PET/CT between January 2018 and February 2020. All imaging studies were performed at our institution. Assessment of therapeutic changes and outcomes was performed.

Results

of the 72 patients imaged with 18F‐FCH PET/CT, 54 subsequently underwent parathyroidectomy. When considering the ability of 18F‐FCH PET/CT alone to predict a uniglandular disease, the sensitivity, specificity, PPV and NPV were 92.7% (95%CI: 80.1—98.5), 46.2% (19.2–74.9), PPV 87.3% (80.5—92) and NPV 61.2% (31.4—84.5), respectively. When we combined the data provided by 18F‐FCH PET/CT with the data already collected from 1st line imaging we were able to complete a minimally invasive surgery in 38 of the 41 (92%) patients with a uniglandular disease. Thirteen patients (24%) had a multiglandular disease, all of them except one underwent bilateral neck exploration based on the data collected by all imaging modalities combined. Overall, cure was achieved in 53 (98%) patients.

Conclusion

18F‐FCH PET/CT, interpreted along with first‐line imaging results in selected patients, can better facilitate utilization of MIS while maintaining exceptional cure rates.
Patient Follow‐up After Orthopaedic Outreach Trips – Do We Know Whether Patients are Improving?
Authors: Leversedge Chelsea , Castro Samuel , Appiani Luis Miguel Castro , Kamal Robin , Shapiro Lauren
Published: June 2022

Background

The burden of traumatic musculoskeletal injuries falls greatest on low‐ and middle‐income countries (LMICs). To help address this burden, organizations host over 6,000 outreach trips annually, 20% of which are orthopaedic. Monitoring post‐surgical outcomes is critical to ensuring care quality; however, the implementation of such monitoring is unknown. The purpose of this review is to identify published follow‐up practices of short‐term orthopaedic surgery outreach trips to LMICs.

Methods

We completed a systematic review of Pubmed, Web of Science, EMBASE, and ProQuest following PRISMA guidelines. Follow‐up method, rate, duration, and types of outcomes measured along with barriers to follow‐up were collected and reported.

Results

The initial search yielded 1,452 articles, 18 of which were eligible. The mean follow‐up time was 5.4 months (range: 15 days‐7 years). The mean follow‐up rate was 65.8% (range: 22%‐100%), the weighted rate was 57.5%. Fifteen studies reported follow‐up at or after 3 months while eight studies reported follow‐up at or after 9 months. Fifteen studies reported follow‐up in person, three reported follow‐up via phone call or SMS. Outcome reporting varied among mortality, complications, and patient‐reported outcomes. The majority (75%) outlined barriers to follow‐up, most commonly noting transportation and costs of follow‐up to the patient.

Conclusions

There is minimal and heterogeneous public reporting of patient outcomes and follow‐up after outreach trips to LMICs, limiting quality assessment and improvement. Future work should address the design and implementation of tools and guidelines to improve follow‐up as well as outcome measurement to ensure provision of high‐quality care.
Non-invasive auditory brainstem responses to FM sweeps in awake big brown bats
Authors: Simmons Andrea Megela , Tuninetti Amaro , Yeoh Brandon M. , Simmons James A.
Published: June 2022

We introduce two EEG techniques, one based on conventional monopolar electrodes and one based on a novel tripolar electrode, to record for the first time auditory brainstem responses (ABRs) from the scalp of unanesthetized, unrestrained big brown bats. Stimuli were frequency-modulated (FM) sweeps varying in sweep direction, sweep duration, and harmonic structure. As expected from previous invasive ABR recordings, upward-sweeping FM signals evoked larger amplitude responses (peak-to-trough amplitude in the latency range of 3–5 ms post-stimulus onset) than downward-sweeping FM signals. Scalp-recorded responses displayed amplitude-latency trading effects as expected from invasive recordings. These two findings validate the reliability of our noninvasive recording techniques. The feasibility of recording noninvasively in unanesthetized, unrestrained bats will energize future research uncovering electrophysiological signatures of perceptual and cognitive processing of biosonar signals in these animals, and allows for better comparison with ABR data from echolocating cetaceans, where invasive experiments are heavily restricted.
Structure and Complexity of 2-Intersection Graphs of 3-Hypergraphs
Authors: Di Marco Niccoló , Frosini Andrea , Kocay William Lawrence , Pergola Elisa , Tarsissi Lama
Published: June 2022

Given a 3-uniform hypergraph H having a set V of vertices, and a set of hyperedges $$T\subset \mathcal {P}(V)$$

T
⊂
P
(
V
)

, whose elements have cardinality three each, a null labelling is an assignment of $$\pm 1$$

±
1

to the hyperedges such that each vertex belongs to the same number of hyperedges labelled $$+1$$

+
1

and $$-1$$

-
1

. A sufficient condition for the existence of a null labelling of H (proved in Di Marco et al. Lect Notes Comput Sci 12757:282–294, 2021) is a Hamiltonian cycle in its 2-intersection graph. The notion of 2-intersection graph generalizes that of intersection graph of an (hyper)graph and extends its effectiveness. The present study first shows that this sufficient condition for the existence of a null labelling in H can not be weakened by requiring only the connectedness of the 2-intersection graph. Then some interesting properties related to their clique configurations are proved. Finally, the main result is proved, the NP-completeness of this characterization and, as a consequence, of the construction of the related 3-hypergraphs.
Generating polycrystalline microstructures with prescribed tensorial texture coefficients
Authors: Kuhn Jannick , Schneider Matti , Sonnweber-Ribic Petra , Böhlke Thomas
Published: June 2022

This work is concerned with synthetic microstructure models of polycrystalline materials. Once a representation of the microstructure is generated, the individual grains need to be furnished with suitable crystal orientations, matching a specific crystal orientation distribution. We introduce a novel method for this task, which permits to prescribe the orientations based on tensorial Fourier coefficients. This compact representation gives rise to the texture coefficient optimization for prescribing orientations method, enabling the determination of representative orientations for digital polycrystalline microstructures. We compare the proposed method to established and dedicated algorithms in terms of the linear elastic as well as the non-linear plastic behavior of a polycrystalline material.
Bayesian time-varying occupancy model for West Nile virus in Ontario, Canada
Authors: Temple Seth D. , Manore Carrie A. , Kaufeld Kimberly A.
Published: June 2022

Occupancy models determine the true presence or absence of a species by adjusting for imperfect detection in surveys. They often assume that species presences can be detected only if sites are occupied during a sampling season. We extended these models to estimate occupancy rates that vary throughout a sampling season as well as account for spatial dependence among sites. For these methods, we constructed a fast Gibbs sampler with the Pólya-Gamma augmentation strategy to conduct inference on covariate effects. We applied these methods to evaluate how environmental conditions and surveillance practices are associated with the presence of West Nile virus in mosquito traps across Ontario, Canada from 2002 to 2017. We found that urban land cover and warm temperatures drove viral occupancy, whereas viral testing on pools with higher proportions of Culex mosquitoes was more likely to result in a positive test for West Nile virus. Models with time-varying occupancy effects achieved much lower Watanabe-Akaike information criteria than models without such effects. Our final model had strong predictive performance on test data that included some of the most extreme seasons, demonstrating the promise of these methods in the study of pathogens spread by mosquito vectors.
Impact of time to first relapse on long-term outcome in adult retroperitoneal sarcoma patients after radical resection
Authors: Guan Huajie , Liu Mengmeng , Cai Shaohui , Ou Biyi , Guan Yuanxiang , Liang Yao
Published: June 2022

Background

Local recurrence of primary retroperitoneal sarcoma (RPS) is one of the major causes of treatment failure and death. We attempted to assess the effects of time to local recurrence (TLR) on the survival after recurrence (SAR) and overall survival (OS) of RPS.

Methods

Included in this study were 224 patients who underwent R0 resection for primary RPS at our institution between January 2000 and December 2020, 118 of whom had local recurrence. Based on the median TLR (19.8 months), patients were divided into two groups: early local recurrence (ELR < 20 months) and late local recurrence (LLR > 20 months). The Kaplan–Meier method was employed to calculate the local recurrence-free survival (LRFS), SAR and OS. Univariate and multivariate analyses were conducted to explore the prognostic value of TLR.

Results

The median follow-up time was 60.5 months for the entire cohort and 58.5 months for the recurrence cohort. There were 60 (50.8%) patients in the ELR group and 58 (49.2%) in the LLR group. The ELR group exhibited a worse SAR (29.2 months vs. 73.4 months, P < 0.001), OS (41.8 months vs. 120.9 months, P < 0.001), and a lower 5-year OS rate (35.9% vs. 73.2%, P = 0.004) than the LLR group. Furthermore, multivariate analysis indicated that TLR was an independent prognostic indicator for SAR (P = 0.014) and OS (P < 0.001).

Conclusions

In patients with RPS, ELR after R0 resection presents adverse effects on OS and SAR than those with LLR, and TLR could serve as a promising predictor for OS and SAR.
Religiosity and Risk of Parkinson’s Disease in England and the USA
Authors: Otaiku Abidemi I.
Published: June 2022

Parkinson’s disease (PD) is associated with low religiosity cross-sectionally. Whether low religiosity might be associated with an increased risk for developing PD is unknown. This study investigated whether low religiosity in adulthood is associated with increased risk for developing PD. A population-based prospective cohort study was conducted. Participants from the English Longitudinal Study of Aging and the Midlife in the United States study who were free from PD at baseline (2004–2011) and completed questionnaires on self-reported religiosity, were included in a pooled analysis. Incident PD was based on self-report. Multivariable logistic regression was used to estimate odds ratios (OR) for developing PD according to baseline religiosity, with adjustment for sociodemographic characteristics, health and lifestyle factors and engagement in religious practices. Among 9,796 participants in the pooled dataset, 74 (0.8%) cases of incident PD were identified during a median follow-up of 8.1 years. In the fully adjusted model, compared with participants who considered religion very important in their lives at baseline, it was found that participants who considered religion “not at all important” in their lives had a tenfold risk of developing PD during follow-up (OR, 9.99; 95% CI 3.28–30.36). Moreover, there was a dose–response relationship between decreasing religiosity and increasing PD risk (P < 0.001 for trend). These associations were similar when adjusting for religious upbringing and when cases occurring within the first two years of follow-up were excluded from the analysis. The association was somewhat attenuated when religious practices were removed from the model as covariates, though it remained statistically significant (OR for “not at all important” vs. “very important”, 2.26; 95% CI 1.03–4.95) (P < 0.029 for trend). This longitudinal study provides evidence for the first time that low religiosity in adulthood may be a strong risk factor for developing PD.
Multi-neighborhood simulated annealing for the sports timetabling competition ITC2021
Authors: Rosati Roberto Maria , Petris Matteo , Di Gaspero Luca , Schaerf Andrea
Published: June 2022

We describe the solver that we developed for the Sports Timetabling Competition ITC2021, a three-stage simulated annealing approach, that makes use of a portfolio of six different neighborhoods. Five of these neighborhoods are taken from the literature on round-robin tournament scheduling, whereas the last one, denoted as PartialSwapTeamsPhased, is a novel contribution and it is specifically designed for the phased version of the problem. We perform a comprehensive and statistically principled tuning procedure to find the best combination of parameters for the competition instances. We dedicate specific focus to evaluate the contribution given by the new neighborhood PartialSwapTeamsPhased, which yielded better results on most phased instances. Overall, the final outcome is that the three-stage simulated annealing solver is able to find a feasible solution on 44 out of 45 instances and ranked second in both the first competition milestone and the final round. We also propose an Integer Linear Programming model implemented in CPLEX, which, unfortunately, did not produce significant results on the instances of the competition.
Effects of an intermittent exercise protocol on ankle control during a single-legged landing
Authors: Ayalath Lakshmi R. , Bini Rodrigo , Wundersitz Daniel W. T. , Weerakkody Nivan , de Noronha Marcos
Published: June 2022

Purpose

To identify the effects of fatigue from an exercise protocol (similar to a soccer match) on ankle motion and forces during single-legged drop landing.

Methods

Seventeen males aged (mean ± SD) 22.2 ± 2.0 years participated in this repeated measures study. A 90-min intermittent exercise protocol with a 15-min rest at halftime was performed. Before, at halftime and after the exercise, participants were tested via a single-legged drop landing task onto a force platform whilst wearing a three-dimensional inertial measurement system (Xsens). Ankle angles (plantarflexion/dorsiflexion and inversion/eversion) were analysed before landing and at peak ground reaction force after landing, and center of pressure was analysed at peak ground reaction force.

Results

No significant differences were found for the outcomes between pre-, halftime and post-exercise (p > 0.05).

Conclusions

Findings suggest that exercises simulating a soccer match (regarding exertion) do not necessarily lead to significant changes in ankle motion or forces around the ankle.
Enhancement of antitumor immune response by radiation therapy combined with dual immune checkpoint inhibitor in a metastatic model of HER2-positive murine tumor
Authors: Misaki Sayaka , Murata Satoshi , Shimoji Miyuki , Iwai Takayasu , Sihombing Andreas Michael , Aoki Ken , Takahashi Yutaka , Watanabe Yoshiyuki
Published: June 2022

Purpose

Treatments for metastatic human epidermal growth factor receptor 2 (HER2)-positive tumors are improving but remain inadequate. We investigated activating antitumor immune response by combining radiation therapy with immune checkpoint inhibitors using mouse tumors overexpressing HER2, a pivotal driver oncogenic antigen, to develop new immunotherapies for metastatic HER2-positive tumors.

Materials and methods

NT2.5 cells were inoculated into the two mammary fat pads of FVB/N mice, which were divided into four groups: no treatment (Non), anti-PD-1 and anti-CTLA4 antibodies (P1C4), irradiation of the large tumor (Rad), and combination (R + P1C4) groups. Tumor growth, immunostaining of tumor-infiltrating lymphocytes, and the proportion of HER2-tumor antigen-specific CD8-positive T cells in the spleen and tumor-infiltrating lymphocytes were analyzed.

Results

In the Rad group, unirradiated and irradiated tumors shrank after treatment. Besides the directly irradiated tumors, the unirradiated tumors in the R + P1C4 group shrank the most. In the unirradiated tumors, CD8-positive T cells and FOXP3-positive T cells accumulated significantly more in the R + P1C4 group than in the P1C4 and the Rad groups (all p < 0.001). CD4-positive helper T cells accumulated significantly more in the R + P1C4 group than in the Rad group (p < 0.05), but this was not significantly different from the P1C4 group. HER2-specific CD8-positive T cells in the spleen and tumor-infiltrating lymphocytes were significantly increased in the R + P1C4 group compared to the P1C4 and Rad groups (all p < 0.0001).

Conclusion

Irradiation of HER2-positive tumors induced an antitumor immune effect against the unirradiated tumor, which was enhanced by the combined use of immune checkpoint inhibitors and was mediated by enhanced recruitment of HER2-tumor antigen-specific cytotoxic T lymphocytes at the tumor site in an HER2-positive mouse tumor model. Harnessing the distant antitumor immune response induced by the combination of radiation therapy and immune checkpoint inhibitors could be a promising treatment strategy for metastatic HER2-positive tumors.
Hazards from lakes and reservoirs: new interpretation of the Vaiont disaster
Authors: Dykes Alan P. , Bromhead Edward N.
Published: June 2022

Hazards in reservoirs and lakes arising from subaerial landslides causing impact waves (or ‘lake tsunamis’) are now well known, with several recent examples having been investigated in detail. The potential scale of such hazards was not widely known at the time of the Vaiont dam project in the 1950s and early 1960s, although a small wave triggered by a landslide at another new reservoir nearby in the Dolomites (northern Italy) drew the possible hazard to the attention of the Vaiont project’s managers. The Vaiont disaster in 1963 arose from a combination of disparate and seemingly unrelated factors and circumstances that led to an occurrence that could not have been imagined at that time. The ultimate cause was a very large landslide moving very rapidly into a reservoir and displacing the water. The resulting wave overtopped the dam to a height of around 175 m and around 2000 people were killed. This paper identifies and examines all of the issues surrounding the Vaiont dam and landslide in order to identify causal factors, contributory factors (including aggravating factors) and underlying factors. In doing so, it demonstrates that the disaster arose from the Vaiont dam project and cannot be attributed simply to the landslide. Underlying geological factors gave rise to the high speed of the landslide, which would have occurred anyway at some time. However, without the contributory factors that account for the presence of the reservoir, i.e. the choice of location for the project and management of the project with respect to a possible landslide hazard, there would have been no disaster. Indeed, the disaster could have been avoided if the reservoir could have been emptied pending further ground investigations. Understanding of this case provides many lessons for future dam projects in mountainous locations but also highlights an ongoing and perhaps under-appreciated risk from similar events involving other water bodies including geologically recent lakes formed behind natural landslide dams.
A Global Perspective on Sustainable Show Cave Tourism
Authors: Chiarini Veronica , Duckeck Jochen , De Waele Jo
Published: June 2022

Caves are among the most visited geological features in the world, attracting over 70 million people every year in more than 1,200 caves worldwide, and amounting up to 800 million Euros in entrance fees alone. The global business of show caves employs roughly 25,000 people directly (management, guides), and at least 100 times more people if we consider the connected tourist activities (souvenir shops, local transport, travel agencies, restaurants, and bars). It is estimated that the whole show cave business has a global commercial value of roughly 2 billion Euros, a number that is increasing constantly. Show caves are generally fragile ecosystems, and care should be taken in their management to safeguard their value for future generations. The international scientific (speleological) community has issued international guidelines for the sustainable development and management of show caves eight years ago, but their application is still far from being applied globally, especially in developing and least developed countries. Cave tourism is expected to increase, especially in countries where caves are abundant but not yet considered as tourist attractions, and where economic and political instability slow down the development of tourism. There are still a lot of possibilities for the opening of new show caves, especially in countries with low Gross Domestic Income (GDI), but their management needs to be sustainable, so that caves become a means of sustaining local economies, educating people on these fragile geo- and ecosystems, and protecting contemporarily their scientific and cultural heritage for future generations.
Held still or pressured to receive dental treatment: self-reported histories of children and adolescents treated by non-specialist dentists in Hordaland, Norway
Authors: Aarvik R. S. , Svendsen E. J. , Agdal M. L.
Published: June 2022

Aim

This study aimed to estimate the prevalence of a self-reported history of restraint in children and adolescents when receiving dental care by non-specialist dentists and to assess differences in dental fear and anxiety (DFA), intra-oral injection fear, and trust in dentists between patients with and without a self-reported history of restraint.

Methods

An electronic cross-sectional survey was distributed to all 9 years old (n = 6686) and 17 years old (n = 6327) in the Public Dental Service in Hordaland County, Norway, in 2019. For statistical evaluation, we generated descriptive statistics and Mann–Whitney U tests.

Results

The response rate ranged between 43.5 and 59.9% for the different questions. The prevalence of a self-reported history of being held still against one’s will during dental treatment and pressured to undergo dental treatment against one’s will was 3.6% and 5.1%, respectively. In general, these patients reported higher DFA, and higher intra-oral injection fear compared with those without such histories of restraint. Patients who had reported being held still against their will during dental treatment had significantly higher distrust in dentists than those who did not report restraint (p < 0.001).

Conclusion

To feel pressured to receive dental treatment and to be held still against one’s will overlap with the concepts of psychological and physical restraint. Patients with a self-reported history of restraint recorded significant differences in DFA, intra-oral injection fear, and trust in dentists compared to those who did not report restraint. Future studies should explore the role that restraint may play in relation to a patient’s DFA, intra-oral injection fear, and trust in dentists.
Efficacy of liraglutide 3.0 mg treatment on weight loss in patients with weight regain after bariatric surgery
Authors: Muratori Fabrizio , Vignati F. , Di Sacco G. , Gavazzi L. , Pellegrino D. , Del Prete M.
Published: June 2022

Purpose

Bariatric surgery, as Roux-en-Y gastric bypass (RYGB), laparoscopic gastric banding (LGB), and laparoscopic sleeve gastrectomy (LSG), is considered the gold standard treatment to achieve long-term weight loss in severe obesity. In patients who fail to maintain the achieved weight, pharmacological treatment may be required. Here, we reported our real-life experience on the efficacy of liraglutide therapy in 62 patients who regained weight after bariatric surgery.

Methods

We retrospectively evaluated 62 (60 F-2 M; mean age: 43.6 ± 9.9 years) patients received liraglutide for weight loss after bariatric surgery (17 RYGB, 22 LGB, and 23 LSG). Body mass index (BMI) before and after surgery was, respectively, of 45.4 ± 5.5 kg/m2 and 29.5 ± 4.9 kg/m2. Patients were followed up from 2016 until 2021. Liraglutide was administered after weight regain once-daily subcutaneously at starting dose of 0.6 mg and with weekly increases up to 3.0 mg. Treatments were administered when a weight regain of 10–15% occurred after reaching a minimum weight loss from bariatric surgery or if weight loss after bariatric surgery was unsatisfactory.

Results

After a mean of 70.7 ± 43.7 months from any bariatric surgery, all patients started liraglutide therapy. At this time, mean BMI was 34.2 ± 4.8 kg/m2 (mean increased BMI: 4.7 ± 2.8 kg/m2). After a mean of 10.5 ± 4.4 months from the beginning of liraglutide, 9 patients achieved normal weight (BMI 24.1 ± 0.9 kg/m2), and 28 were overweight (BMI 26.9 ± 1.6 kg/m2). Twenty patients achieved grade I (BMI 32.1 ± 1.5 kg/m2), 5 grade II (BMI 37.3 ± 2.0 kg/m2) obesity, and none had grade III obesity (mean BMI change: − 5.1 ± 2.5 kg/m2). The treatment was well tolerated, and no serious adverse events were recorded.

Conclusion

These data confirm the efficacy and safety of liraglutide in patients who experienced weight regain after bariatric surgery. Considering the long-term follow-up, patients should be followed up regularly and the pharmacological treatment should be adapted to the weight fluctuations observed during the clinical history.

Level of evidence

V. Opinions of authorities, based on descriptive studies, narrative reviews, clinical experience, or reports of expert committees.
Manufacturing oxide-dispersion-strengthened steels using the advanced directed energy deposition process of high-speed laser cladding
Authors: Wilms Markus B. , Pirch Norbert , Gökce Bilal
Published: June 2022

In this work, we demonstrate the feasibility of manufacturing an iron-based oxide-dispersion-strengthened (ODS) PM2000 composite material with the chemical composition of Fe20Cr4.5Al0.5Ti + 0.5Y2O3 (in wt.%) via the advanced directed energy deposition (DED) process of high-speed laser cladding (HSLC). The characteristic high solidification rates of HSLC processes allow the successful dispersion of nano-scaled yttrium-based oxides in the ferritic stainless steel matrix. The effective suppression of nano-particle agglomeration during the melting stage, which is frequently observed in conventional DED processes of ODS materials, is reflected by smaller dispersoid sizes and corresponding higher hardness of manufactured specimen compared to DED-manufactured counterparts.
Clay Minerals in Interbedded Sandstones and Shales of the Miocene Surma Group, Sylhet Trough, Bengal Basin (northeastern Indian Plate): Implications for Future Hydrocarbon Exploration
Authors: Khanam Farida , Rahman M. Julleh Jalalur , Abdullah Rashed
Published: June 2022

Clay minerals are common constituents of the Miocene Surma Group reservoir rocks in the Sylhet Trough, Bengal Basin, and may exert significant controls on reservoir quality. The relationship between diagenetic clay minerals and reservoir quality in the petroliferous Sylhet Trough is poorly understood, however. The current study was aimed at the origin and diagenetic pattern of clay minerals in interbedded sandstones and shales using thin-section petrography, scanning electron microscopy (SEM), and X-ray diffraction (XRD), and understanding their diagenetic effects on reservoir quality. The results showed that the clay mineral cements in sandstones comprise mainly chlorite, illite/illite-smectite, and minor smectite and kaolinite. In the early diagenetic stage, clay rims and growth of vermiform kaolinite occur and partly occlude the pore throats. Deep burial effects include pore-filling, pore-lining, and grain-coating authigenic clays (mainly chlorite and illite). Diagenetic clay minerals and mechanical clay infiltration showed a systematic distribution in sandstones lying in the vicinity of sequence and parasequence boundaries. In a lowstand systems tract (LST), clay minerals within the sandstones commonly include mechanically infiltrated smectitic clays that eventually evolved to grain-coating chlorite and/or illite during the meso-diagenesis stage. The presence of clays/clay minerals has no significant impact upon reservoir quality of sandstones. The Surma Group shales are enriched in illite with significant proportions of chlorite and kaolinite and are likely to be mainly detrital, with diagenetic changes of smectite to illite.
Factor associated with surgical site infection of women who undergone cesarean section in Hawassa University comprehensive specialized hospital southern Ethiopia, retrospective study design
Authors: Gashaw Amanu , Fantu Shimelis , Tarekegn Mulate
Published: June 2022

ABSTRACT

Background:

Cesarean delivery is the most common major operation carried out in obstetrics worldwide, and is the single most important risk factor for postpartum maternal infection. Women undergoing cesarean delivery have a 5 to 20-fold greater chance of getting an infection compared with women who give birth vaginally. Currently, variable rates of surgical site infection, and women stayed longer after the procedure due to this infection. This study aims to know the real magnitude and associated factors.

Method:

Retrospective study design was used. A total of 431 cases were included by systematic random sampling from the cases that had undergone cesarean section during the study period. Data was collected using a pretested structured questionnaire. Data were entered into SPSS for analysis. Descriptive analysis was made also Bivariate and multivariate logistics have been made to see the relationship between the dependent and independent variables. The strength of associations was presented by odds ratio and a 95% confidence interval P-value<0.05 was considered statistically significant.

Results:

The magnitude of surgical site infection was 11.8% and about 98% were developed within two weeks. In this study, multiple vaginal examination rupture of membrane, prolonged labor, and estimated blood loss >500 ml were associated factors.

Conclusion:

the magnitude of SSI was high; and multiple vaginal examinations, rupture of membranes, prolonged labor, and estimated blood loss> 500 ml were significant factors for the occurrence.

High light
Uniform Properties of Ideals in Rings of Restricted Power Series
Authors: Barnicle Madeline G.
Published: June 2022

When is an ideal of a ring radical or prime? By examining its generators, one may in many cases definably and uniformly test the ideal’s properties. We seek to establish such definable formulas in rings of p-adic power series, such as
$\mathbb Q_{p}\langle X\rangle $
,
$\mathbb Z_{p}\langle X\rangle $
, and related rings of power series over more general valuation rings and their fraction fields. We obtain a definable, uniform test for radicality, and, in the one-dimensional case, for primality. This builds upon the techniques stemming from the proof of the quantifier elimination results for the analytic theory of the p-adic integers by Denef and van den Dries, and the linear algebra methods of Hermann and Seidenberg.

Abstract prepared by Madeline G. Barnicle.

E-mail: barnicle@math.ucla.edu

URL: https://escholarship.org/uc/item/6t02q9s4
Paraconsistent Logic Programming in Three and Four-Valued Logics
Authors: Oliveira Kleidson Êglicio Carvalho da Silva
Published: June 2022

From the interaction among areas such as Computer Science, Formal Logic, and Automated Deduction arises an important new subject called Logic Programming. This has been used continuously in the theoretical study and practical applications in various fields of Artificial Intelligence. After the emergence of a wide variety of non-classical logics and the understanding of the limitations presented by first-order classical logic, it became necessary to consider logic programming based on other types of reasoning in addition to classical reasoning. A type of reasoning that has been well studied is the paraconsistent, that is, the reasoning that tolerates contradictions. However, although there are many paraconsistent logics with different types of semantics, their application to logic programming is more delicate than it first appears, requiring an in-depth study of what can or cannot be transferred directly from classical first-order logic to other types of logic.

Based on studies of Tarcisio Rodrigues on the foundations of Paraconsistent Logic Programming (2010) for some Logics of Formal Inconsistency (LFIs), this thesis intends to resume the research of Rodrigues and place it in the specific context of LFIs with three- and four-valued semantics. This kind of logics are interesting from the computational point of view, as presented by Luiz Silvestrini in his Ph.D. thesis entitled “A new approach to the concept of quase-truth” (2011), and by Marcelo Coniglio and Martín Figallo in the article “Hilbert-style presentations of two logics associated to tetravalent modal algebras” [Studia Logica (2012)]. Based on original techniques, this study aims to define well-founded systems of paraconsistent logic programming based on well-known logics, in contrast to the ad hoc approaches to this question found in the literature.

Abstract prepared by Kleidson Êglicio Carvalho da Silva Oliveira.

E-mail: kecso10@yahoo.com.br

URL: http://repositorio.unicamp.br/jspui/handle/REPOSIP/322632
Proof Mining with the Bounded Functional Interpretation
Authors: Pinto Pedro
Published: June 2022

In this doctoral thesis, we show how the bounded functional interpretation of F. Ferreira and P. Oliva can be used and contribute to the Proof Mining program, a program which aims to extract computational information from mathematical theorems using proof-theoretic techniques. We present a method for the elimination of sequential weak compactness arguments from the quantitative analysis of certain mathematical results. This method works as a “macro” and allowed us to obtain quantitative versions of important results of F. E. Browder, R. Wittmann, and H. H. Bauschke in fixed point theory in Hilbert spaces. Although the theorems of Browder and Wittmann were previously analyzed by U. Kohlenbach using the monotone functional interpretation, it was not clear why such analyses did not require the use of functionals defined by bar recursion. This phenomenon is now fully understood by a theoretical justification for the elimination of sequential weak compactness in the context of the bounded functional interpretation. Bauschke’s theorem is an important generalization of Wittmann’s theorem and its original proof is also analyzed here. The analyses of these results also require a quantitative version of a projection argument which turned out to be simpler when guided by the bounded functional interpretation than when using the monotone functional interpretation. In the context of the theory of monotone operators, results due to Boikanyo/Moroşanu and Xu for the strong convergence of variants of the proximal point algorithm are analyzed and bounds on the metastablility property of these iterations are obtained. These results are the first applications of the bounded functional interpretation to the proof mining of concrete mathematical results.

Abstract prepared by Pedro Pinto.

E-mail: pinto@mathematik.tu-darmstadt.de

URL: http://hdl.handle.net/10451/42661
On Logics and Semantics for Interpretability
Authors: Mikec Luka
Published: June 2022

We study various properties of formalised relativised interpretability. In the central part of this thesis we study for different interpretability logics the following aspects: completeness for modal semantics, decidability and algorithmic complexity.

In particular, we study two basic types of relational semantics for interpretability logics. One is the Veltman semantics, which we shall refer to as the regular or ordinary semantics; the other is called generalised Veltman semantics. In the recent years and especially during the writing of this thesis, generalised Veltman semantics was shown to be particularly well-suited as a relational semantics for interpretability logics. In particular, modal completeness results are easier to obtain in some cases; and decidability can be proven via filtration in all known cases. We prove various new and reprove some old completeness results with respect to the generalised semantics. We use the method of filtration to obtain the finite model property for various logics.

Apart from results concerning semantics in its own right, we also apply methods from semantics to determine decidability (implied by the finite model property) and complexity of provability (and consistency) problems for certain interpretability logics.

From the arithmetical standpoint, we explore three different series of interpretability principles. For two of them, for which arithmetical and modal soundness was already known, we give a new proof of arithmetical soundness. The third series results from our modal considerations. We prove it arithmetically sound and also characterise frame conditions w.r.t. ordinary Veltman semantics. We also prove results concerning the new series and generalised Veltman semantics.

Abstract prepared by Luka Mikec.

E-mail: luka.mikec1@gmail.com

URL: http://hdl.handle.net/2445/177373
Quasi-isolated blocks and the Alperin–McKay conjecture
Authors: Ruhstorfer Lucas
Published: June 2022

The Alperin–McKay conjecture is a longstanding open conjecture in the representation theory of finite groups. Späth showed that the Alperin–McKay conjecture holds if the so-called inductive Alperin–McKay (iAM) condition holds for all finite simple groups. In a previous paper, the author has proved that it is enough to verify the inductive condition for quasi-isolated blocks of groups of Lie type. In this paper, we show that the verification of the iAM-condition can be further reduced in many cases to isolated blocks. As a consequence of this, we obtain a proof of the Alperin–McKay conjecture for$2$-blocks of finite groups with abelian defect.
I. History and Horizons of Lay Ecclesial Ministry in the US Catholic Church
Authors: Yount Mary Beth
Published: June 2022

This theological roundtable has stand-alone articles that are complementary and together trace a flow toward ecclesial participation, of movements of bodies and voices, toward full inclusion in the Catholic Church. These works, taken together, can shed light on the dynamism and development of the church when it responds to pressing social and cultural needs—from official development of structures within the ordained magisterium in response to poverty and economic crises (Yount) to students moving together for change and participatory inclusion (Ahern) and from lay adults forming social action communities for racial justice (Rademacher) and, building on the experience of lay LGBTQ+ Catholics, to demand ecclesial participation (Flanagan). It is movements such as these that call and enact development in the church, and knowing what has come before can prompt our own reflection on what needs to come next and the role of each of us in that.
III. Pre-Conciliar Specialized Catholic Action and the Pursuit of Racial Justice in the United States
Authors: Rademacher Nicholas
Published: June 2022

Eileen Fagan's and Janice Thompson's thoughtful and provocative call for papers in the Mysticism and Politics section of the 2021 College Theology Society (CTS) Annual Meeting prompted me to think anew about the complex legacy of the Friendship House (FH) movement in the United States. Fagan and Thompson invited papers that would help CTS members reflect on how we might “approach our world with a ‘mysticism of open eyes’ and an ‘attitude of encounter’” and to “think of and act on behalf of a future that shows Christianity embracing human dignity and common good for all God's people.” A look to the past can help us work more effectively in the present for that kind of future. The history of Friendship House, a mid-twentieth-century Catholic interracial movement, combined spirituality and action for justice in ways that merit a closer look. More specifically, the archival and published material from the Friendship House movement in the 1940s illustrates the legacy of one Catholic action initiative centered on racial justice that combined spirituality and political action for the common good. This history can help contemporaries track ways that Catholics have been involved in such movements and might be engaged in similar efforts today.