bluuebunny/crossref_metadata_2025 huggingface dataset:
Chronic Mucocutaneous Candidiasis with Candida Granuloma Treated with 5-Fluorocytosine
Authors: Lee Sungnack , Kim Hong-Jig
Published: October 2009

A 19-year-old male had chronic mucocutaneous candidiasis with typical granuloma on the face, scalp and genital area. He had defects in cell-mediated immunity (cutaneous anergy to common antigens, but normal number of T lymphocytes and normal lymphocyte transformation with phytohemagglutinin), and there were no endocrine deficiencies. He had systemic involvement, including lungs, kidneys, liver and spleen diagnosed by radiologic studies. In the histologic findings of the skin, typical features were seen of Candida granuloma lesions, and hyphae and spores of Candida albicans also were identified in the Malpighian layer. Therapy with 5-fluorocytosine resulted in a remarkable improvement.
Photochemotherapy of Sézary Syndrome
Authors: Kövary P.M. , Frosch P. , Macher E.
Published: October 2009

Photochemotherapy was effectively applied in 4 patients with Sézary syndrome. Clinically, complete clearing of the skin could be achieved by this kind of treatment. Photochemotherapy may be recommended as a useful treatment of less advanced cases for patients with no history of extreme sun sensitivity.
In vitro Availability Profiles of Oral Methoxsalen Commercial Products
Authors: Morad Abdel-Rehim , Hikal Ahmed H. , El-Sawalhy Hussein A.
Published: October 2009

The in vitro release rate of methoxsalen from three commercially available tablets and an experimental tablet were evaluated at pH 2 and 7, using the USP dissolution test. The experimental tablet and one commercial product showed that 74% of the labeled amount is released in 1 h and almost completely released after 3 h at pH 2 and 7. Two products showed that only 12 and 10% of the labeled amount was released in 1 h and a maximum of 25 and 23% after 3 h at pH 2. At pH 7, the percent released from these two products were slightly higher. These results correlate with the reported clinical effectiveness of one of the products showing fast methoxsalen release. Since exposure to long-wave UV radiation is carried out 1–3 h following methoxsalen oral administration, delayed release might explain the failure of some products to give satisfactory clinical results.
Immune Phenomena in Patients with Pustular Bacterid
Authors: Djawari D. , Deinlein E. , Hornstein O.P.
Published: October 2009

In 20 patients with histologically confirmed pustular bacterid the immuno-logical status was checked including lymphocyte and granulocyte components of the cellular immune system as well as HLA typing. For comparison the same investigations were carried out in 20 healthy controls. In contrast to the controls, in the group of patients the chemotactic activity of polymorphonuclear leukocytes as well as their ability to engulf either vital or heat-inactivated Candida albicans cells was found to be slightly impaired (p ≤ 0.01 and 0.05, respectively). Killing of C. albicans cells by polymorphonuclear leukocytes was strikingly impaired (p ≤ 0.001). NADPH-dependent oxidase activity, however, was found to be normal. Impairment of chemotaxis and killing activity could not be substantiated in AB pool serum, thus a serum-dependent disorder of granulocyte function has to be assumed. Lymphocyte response to phytohemagglutinin was reduced in all patients, whereas intracutaneous test reactivity to microbial antigens was normal. T and B cell counts in peripheral blood were within normal range. HLA typing revealed a significantly increased prevalence rate of HLA-B14 as compared with the control group and other patients.
Mast Cells in Behçet’s Disease: Ultrastructural and Histamine Content Studies
Authors: Lichtig C. , Haim S. , Gilhar A. , Hammel I. , Ludatscher R.
Published: October 2009

In order to assess the role of mast cells in the pathogenesis of mucocuta-neous lesions of Behçet’s disease, the following investigations were performed: (1) a comparative study of ultrastructural features of mast cells in sopntaneous and reactive (pa-thergic) lesions of the process and in apparently uninvolved skin of patients in the active stage of the disease; (2) comparative estimation of the histamine content at the site of cutaneous hyperreactivity lesions and in apparently uninvolved skin of the same patients. Various forms and degrees of degranulation were revealed among the mast cells. These forms were obviously more frequent in spontaneous and reactive lesions than in the uninvolved skin, 66 and 56% as compared with 7.7%. Also the histamine content was twofold more in the reactive lesions than in the unaffected skin of the same patient, 43 ng/mg tissue as compared with 21 ng/mg tissue. The results of our study seem suggestive of an active role of mast cells in this process. The role is probably similar to that of basophils in cutaneous basophilic hypersensitivity.
Effect of Topical Diflumidone on Ultraviolet-Light-Induced Erythema
Authors: Gomez Edward C. , Trancik Ronald J.
Published: October 2009

The relative topical efficacy of indomethacin and diflumidone, a novel nonsteroidal antiinflammatory drug, for the suppression of ultraviolet-light (290–320 nm region; UVB)-induced erythema has been compared in a randomized, double-blind, placebo-controlled study in man. During the early phases of erythema development (3–6 h) following the administration of 3 minimal erythema doses (MED) of UVB, a single topical application of diflumidone and of indomethacin were found to be equal in their ability to inhibit the development of erythema compared to untreated or placebo-treated sites. At 24 h after application, the indomethacin-treated sites had significantly less erythema than did the diflumidone-treated sites. Pigmentation of test sites at 5 and 14 days following irradiation was indistinguishable at the diflumidone, placebo, or untreated sites, but relatively less pigment developed at the indomethacin-treated sites.
Increased Frequency of Multiple Primary Melanomas in Hereditary Familial Melanoma
Authors: Bork K. , Bräuninger W. , Nake A.
Published: October 2009

Multiple primary melanomas can be observed in a frequency of 1–4% in melanoma patients, while they obviously occur more frequently in hereditary familial melanoma. In every 8th patient with an – in itself rare – hereditary familial melanoma a development of two or more primary melanomas has to be expected. Casuistically, a family is reported where a 14-year-old girl died of malignant melanoma, whose mother later on developed two primary malignant melanomas in an interval of 2 years.
Pilomatricomas: Association with Myotonic Dystrophy
Authors: Aso Miki , Shimao Shuhei , Takahashi Kazuo
Published: October 2009

The association of pilomatricomas with myotonic dystrophy is rare. The following is the 11th case. Some clinical characteristic features suggest that patients with myotonic dystrophy have a predisposition to develop pilomatricomas.
Adverse Reactions of the Skin to Metoprolol and Other Beta-Adrenoreceptor-Blocking Agents
Authors: Neumann H.A.M. , van Joost T.
Published: October 2009

Oral provocation tests revealed the relation between long-term oral use of metoprolol and development of psoriasiform and/or eczematous skin lesions in 3 patients. The clinical and histopathological findings in 1 case are described more in detail and are discussed. The data in the recent literature, with respect to side effects of skin due to different β-blocking agents, are summarized. In addition, some aspects dealing with possible mechanism in the side effects of β-blocking agents are briefly discussed. Since β-blocking agents may cause similar side effects, as described during practolol treatment, one should still be alert to this possibility during long-term treatment with (new) β-blocking agents, which may allow us to prevent serious damage that might occur in different organs.
Metastatic Skin Calcification
Authors: de Graaf P. , Ruiter D.J. , Scheffer E. , Schicht I.M. , van Vloten W.A. , de Graeff J.
Published: October 2009

Calcification of the skin could not be demonstrated in 60 skin biopsy specimens, selectively obtained from 30 chronic hemodialysis patients; 21 of these patients had metastatic calcification at other sites. These results support the proposed rarity of metastatic skin calcification in patients with chronic renal failure. The cause of this phenomenon is not precisely known.
Incidence of Dermatophytes in the San Francisco Bay Area
Authors: Aly Raza
Published: October 2009

A total of 1,101 patients was studied for the incidence and distribution of dermatophytes in the San Francisco Bay Area from 1974 to 1978. 267 dermatophytes were isolated and identified. Trichophyton rubrum and Triehophyton tonsurans were the most prevalent dermatophytes. T. rubrum caused 83% of tinea pedis, 82% of tinea unguium, 80% of tinea manuum and 66% of tinea cruris. T. tonsurans was the major cause of tinea capitis (60%) followed by Microsporum canis. Microsporum audouinii was not encountered in this survey.
Chondrodermatitis nodularis chronica helicis
Authors: Goette Detlef K.
Published: October 2009

A patient with clinically and histologically characteristic chondrodermatitis nodularis chronica helicis (CNCH) had histologic evidence of transepithelial elimination (TE). Results of a review of 10 other histologic specimens of CNCH yielded three cases with features of TE. Pictorial presentation of yet another example was found in the literature. It is suggested that CNCH should be included in the ever-expanding group of TE disorders.
Generalized Familial Benign Chronic Pemphigus
Authors: Friedman-Bimbaum R. , Haim S. , Marcus S.
Published: October 2009

This is a report of generalized familial benign chronic pemphigus in a Negro male. The rich staphylococcal and streptococcal flora detected on the skin of this patient may have been a factor in the generalization of the process.
Lokaltherapie der Alopecia androgenetica mit 17α-Östradiol
Authors: Orfanos C.E. , Vogels L.
Published: October 2009

In a controlled, randomized double-blind study, 51 patients with androgenetic alopecia and increased hair loss (telogen rate > 20%) were treated by local application of hair lotions with and without 17α-estradiol (0.025%) for a period of at least 6 months. Before and after therapy trichograms were taken and evaluated under standardized conditions. In 63% of the treated patients a reduction of the amount of telogen hairs appeared, whereas in the control group the same reduction was found in only 37% of the cases. Similarly, in the treated group only 11% of the patients worsened, in contrast to 50% of the control group who showed an increased telogen rate (> 10%). The amount of growing anagen hairs and of seborrhea did not change significantly in both groups. Side effects were not seen. These findings indicate that hair lotions containing 17α-estradiol may have a therapeutic value in reducing androgenetic hair loss, if applied topically for a long period of time, similar to 17β-estradiol. However, no regrowth of new hair was found.
Bowen’s Disease and Squamous Cell Carcinoma of the Palm
Authors: Binet O. , Beltzer-Garelli E. , Elbaz J.S. , Aron-Brunetière R.
Published: October 2009

A case of Bowen’s disease of the palm with associated squamous cell carcinoma is described. A brief general review underlines this unusual localization. Bowen’s disease may occur at any cutaneous site, simultaneously involving areas protected from and exposed to the light. Involvement of the dorsum of the hand is not rare, but palmar involvement is highly unusual. Only 12 indisputable cases have been published up to the present time.
Angiolymphoid Hyperplasia with Eosinophilia
Authors: Rehák A. , Bou-Resli M. , Mousa Ahmed M. , Al-Zaid N.S.
Published: October 2009

Ultrastructural investigation of a case of papular (dermal) lymphoid hyperplasia with eosinophilia revealed in the proliferating tissue rounded inclusion bodies made up of smaller particles which formed within the lysosomal vacuoles and sometimes occupied a large proportion of the cytoplasm. The bodies also occur in the extracellular spaces. Apart from this, groups of mosaic-like particles and concentric bodies with a central core suggesting viral provenance were demonstrated.
Abnormally Low Plasma Zinc Levels in Pustular Psoriasis
Authors: Thune Per
Published: October 2009

In 4 patients with pustular psoriasis plasma zinc determinations were performed during exacerbations and remissions. Very low values were detected with a normalizing tendency during periods of remission.
The Sign of Leser-Trélat in Association with Lymphocytic Lymphoma
Authors: Halevy Sima , Halevy Jonathan , Feuerman Eleasar J.
Published: October 2009

The sign of Leser-Trélat was observed in a patient with multiple seborrheic keratoses and hemangiomata. The increase in these lesions of the skin preceded the development of a poorly differentiated lymphocytic lymphoma, a type of malignancy which has not yet been reported in association with this sign.
Cutaneous Pigmentation: A Probable Sign of Spontaneous Bacterial Peritonitis
Authors: Pollack S. , Haim S. , Enat R. , Barzilai D.
Published: October 2009

A cirrhotic patient with ascites was apparently well managed with diuretics and salt and water restriction for 9 months. A spontaneous bacterial peritonitis (SBP) developed and the patient finally died following septic shock. There were enough findings indicating that SBP in this case had been existing silently for some time. During this period the only apparent manifestation of this complication was a cutaneous pigmentation on the abdomen. It is suggested that pigmentation may be included among other presentations of this frequently silent process.
Degenerative Collagenous Plaque of the Hand (Linear Keratoelastoidosis of the Hands)
Authors: Sehgal V.N. , Singh M. , Korrane R.V. , Nayyar M. , Chandra M.
Published: October 2009

Clinical and histological features of three examples of degenerative collagenous plaques of the hands in Indian housewives have been described in detail in order to focus attention on a hitherto uncommon entity. Household trauma has been incriminated as the precipitating or a triggering factor in these cases.
A Peculiar Case of Sporotrichosis
Authors: Hachisuka Hiroshi , Sasai Yoichiro
Published: October 2009

A case of localized cutaneous sporotrichosis is reported. The lesion was granulomatous, without lymphatic metastasis. Histological examination revealed numerous spores and asteroid bodies. Sporotrichin reaction was negative, but after treatment with potassium iodide became positive. The peculiar features of this case seem to be due to some disturbances of cellular immunity.
Woringer-Kolopp Disease
Authors: Aliaga A. , Bombi J.A. , Barbera E. , Fortea J.M.
Published: October 2009

For the purpose of describing a new case of the Woringer-Kolopp disease, we are up-dating the problem and its classification and contributing clinical, histopathological, and ultrastructural facts which show that this is a lymphoma of the T cells and therefore should be classified along with the mycosis fungoides and the Sézary syndrome. The identification test of the lymphocytes and the ultrastructural study bring to light new facts of this disease.
Scopulariopsis onychomycosis Treated with Natamycin
Authors: Onsberg Per , Stahl Dorrit
Published: October 2009

7 patients with Scopulariopsis brevicaulis onychomycosis of the toe-nails were treated locally with 1% natamycin in 60% dimethylsulphoxide. After 3–5 months treatment the fungus could no longer be isolated from the nails, and at follow-up 15 months after the completion of the treatment, 2 patients reported permanent improvement of the nails and 3 a complete cure. In 1 patient the treatment was ineffective.
A Case of Cryoglobulinemic Gangrene in Myeloma with Fatal Outcome Despite Successful Skin Grafting
Authors: Narita Hiromi , Ogata Katsumi , Kikuchi Ichiro , Inoue Shohei
Published: October 2009

Extensive necrosis of the skin, muscle and bone was produced after prolonged cooling in a case of myeloma with cryoglobulinemia. Skin grafting was beneficial.
Purpuric Pityriasis Rosea
Authors: Verbov Julian
Published: October 2009

Occasional cases of pityriasis rosea show few or many purpuric lesions and 3 patients with such lesions are described.
Treatment of the Common Wart by Induced Allergic Inflammation
Authors: Eriksen Knud
Published: October 2009

In an uncontrolled investigation 63 selected patients with verrucae vulgares were sensitized with DNCB (1-chloro-2,4-dinitrobenzene) with subsequent regular painting of the warts with DNCB. Only 86% of these patients could be sensitized, in contrast to 96% in a normal population. 20 patients had to be excluded from the material on account of defaulting or defective sensitization. In the remainder of the patients allergic type IV inflammation developed around the painted warts and 1 patient developed an urticarial type I reaction around the warts and on the body. In the patients with multiple warts, 80% (24/30) were cured. This corresponds to the percentage cure in patients with solitary warts. Complement-binding wart virus antibodies were present in 15% of the patients prior to the treatment and in 43% after the conclusion of treatment. This investigation provides a new method of treatment of verrucae vulgares and suggests that regression in the warts is immunologically conditioned. On account of the risk of allergic side effects, the method should be carried out in special departments only.
Hereditäres Angioödem: Komplementprofil unter einer Langzeitbehandlung mit Danazol
Authors: Wüthrich B. , Grob P.J.
Published: October 2009

A mother and her son are described who both suffer from hereditary angiooedema. Both were treated with Danazol, a synthetic derivative of ethisterone. The prophylactic clinical effect seemed obvious, and also the serum concentration of the complement component C4, which had regularly been lower before treatment, became normal. However, no change of the serum concentration of the C1 esterase inhibitor could be demonstrated; this is in contrast to observations of other authors.
Richner-Hanhart Syndrome and Tyrosinemia Type II
Authors: Hunziker Nicole
Published: October 2009

A patient already published as a case of Richner-Hanhart syndrome (RHS) (stabilized corneal lesions and hyperkeratotic lesions on the palms and soles) proved to be associated with tyrosinemia type II. 2 other cases (sister and brother) with only typical dermatologic features of RHS and tyrosinemia type II are described. The treatment with a low phenylalanine and tyrosine diet improves the cutaneous lesions in our 3 cases.
Paraffinomes multiples thoraco-abdominaux
Authors: Dumont-Fruytier M. , Tennstedt D. , Lachapelle J.M.
Published: October 2009

We report the case of a man aged 39 who received several injections of mineral oil in his pectoral muscles 20 years ago. Supposedly, the purpose of the injections was to improve the aesthetic appearance as well as the strength of the muscles. The final result was the development of impressive symmetrical paraffinomas. A short review of the recent literature on paraffinomas is presented.
Circulating Antibodies in Malignant Melanoma Patients
Authors: Betterle C. , Peserico A. , Bersani G. , Ninfo V. , Del Prete G.F. , Stefani R. , Nitti D.
Published: October 2009

Sera from 46 patients with malignant melanoma (MM) in different clinical stages and from 25 healthy blood donors were studied by an indirect conventional immunofluorescent technique (IIT) and by an immunofluorescent complement-fixation test (ICFT). No specific and reliable serological reactivity could be demonstrated against autologous and homologous MM and other nonmalignant pigmented tissues. An increased incidence of diffused antinuclear (ANA; 41%) and cytoplasmic epidermal cell autoantibodies (A-CYT; 71%) was observed in the patients by IIT. Statistical evaluation of the results gave significant values in the χ2 test in patients for ANA (χ2 = 5.2061; p < 0.05) and for A-CYT (χ2 = 8.9176; p < 0.01) versus age-matched controls. Thyroid microsomal, gastric parietal cell, smooth muscle and mitochondria autoantibodies were, respectively, detected in 4.3, 4.3, 4.3 and 0% of patients’ sera.
Isolated Epidermolytic Acanthoma
Authors: Niizuma Kan
Published: October 2009

A solitary scrotal lesion of isolated epidermolytic acanthoma was studied by optical microscopy. The lesion displayed typical granular degeneration. The tumor parenchyma comprised several foci extending deep in the cutis to the continuation of the invaginated epithelium. Serial sections showed the parenchyma was free from acrosyringium and epidermis proper. The findings with hematoxylin-eosin stain and Fontana-Masson stain indicated that the tumor had originated from portion B of the hair follicle.
Pili Torti with Deafness (Bjørnstad Syndrome)
Authors: Voigtländer Volker
Published: October 2009

A family with the Bjørnstad syndrome in 2 siblings is reported. The pedigree suggests a recessive pattern of inheritance.
Pemphigus herpétiforme (spongiose à éosinophiles)
Authors: Binet O. , Girarä J. , Beltzer-Garelly E. , Avram A. , Césctrini J.P.P. , Aron-Brunetière R.
Published: October 2009

A 71-year-old male had a clinically atypical pemphigus (pemphigus herpetiformis), associated with histopathologic eosinophilic spongiosis. This case is discussed and was frequently found reported in iatrogenic pemphigus.
Becker’s Melanosis: an Ultrastructural Study
Authors: Bhawan Jag , Chang Wallace H.
Published: October 2009

Becker’s melanosis is an uncommon condition characterized by hypertrichosis, hyperpigmentation of the epidermis, dermal melanophages and absence of nevus cells. Ultrastructural examination of such a melanotic lesion from a young white man revealed giant melanosomes. In addition, normal-sized melanosomes were found singly in the keratin ocytes of the involved skin. Dermal venules were surrounded by multiple layers of basement membrane.
Relationship of Pityriasis Amiantacea to Psoriasis
Authors: Hersle K. , Lindholm A. , Mobacken H. , Sandberg L.
Published: October 2009

46 patients with pityriasis amiantacea have been reexamined with regard to the later development of psoriasis and atopic diseases, and their occurrence in first and second degree relatives. HLA antigens of the A, B and C series were also determined. Earlier suggestions of a close association with psoriasis were not confirmed. An association with atopic diseases could not be established. Occurrence of seborrheic dermatitis seems, however, common in patients with pityriasis amiantacea.
An Abortive Form of Pemphigus Vulgaris Probably Induced by Penicillin
Authors: Ruocco V. , Rossi A. , Pisani M. , Astarita C.A. , Alviggi L.
Published: October 2009

A case of an abortive form of pemphigus probably induced by protracted penicillin treatment is reported. Because of a positive patch test with penicillamine and the finding of such an amino acid in patient’s plasma, the authors are induced to believe that the trigger factor could really have been penicillamine formed by the metabolic breakdown of the penicillin molecule.
Influence du stratum corneum sur la perspiration insensible et sur la biodisponibilité d’un nouveau stéroïde topique, le difluprednate
Authors: Lafille C. , Barbier A. , Girard J.
Published: October 2009

Comparative study of experimental and theoretical curves obtained by plotting transepidermal water loss against stratum corneum thickness in man, shows that every layer in the stratum corneum acts as part of the epidermal barrier to water loss. Another function of the stratum corneum is to decrease the cutaneous penetration of topical corticosteroids like difluprednate and to modify their bioavailability (‘corticosteroid reservoir’) Our data suggest that variations in stratum corneum thickness between subjects explain variation of transepidermal water loss and sensitivity difluprednate, as there is a close relationship between these two parameters. It is then conceivable that the phototype has clinical implications if there really exists a relationship between phototype, stratum corneum thickness and sensitivity to steroids.
Mycoses iatrogènes à localisation profonde dues à des champignons levuriformes opportunistes
Authors: Drouhet E. , Dupont B.
Published: October 2009

The new therapeutic methods based on antibiotics, corticosteroids and immunosuppressors and the new medicosurgical techniques (catheters, monitoring in intensive-care units, open-heart surgery) modify the host, favorise the adaptation and introduction of endogenous and exogenous yeast-like fungi and thus create a new pathology characterized by deep visceral or septicemic infections due to yeasts belonging to the genera Candida, Torulopsis, Cryptococcus, Trichosporon, Rhodotorula, and Saccharomyces. The pathological aspects are analyzed and therapy is suggested in the light of new findings on polyenes (nystatine, amphotericine B), 5-fluorocytosine, imidazole, derivatives (miconazole, econazole) considering their association in function of synergy or antagonism possibilities.
Recherche sur les kératinophiles du sol et leur incidence sur la pathologie cutanée humaine dans la région lyonnaise
Authors: Coudert J. , Michel-Brim J. , Mojon M. , Pichot J.
Published: October 2009

Between 1967 and 1977, the systematic research of kératinophiles of the ground in a radius of 30–50 km around Lyon, has shown the ubiquitarian predominance of Microsporum nanum, which is probably the most ancient occupant of the ground. The most intensive areas of human and animal occupation in the Rhodanian tract show the predominance of Microsporum gypseum, which is scarcely found in man. Sporadic localizations, tightly limited, bound to circulation axes and international gathering, let us detect Microsporum cookeiTrichophyton verrucosum, Trichophytonmentagrophytes Chrysosporium keratinophilum, and Keratinomyces ajelloi. However, in the last years, a progressive extension of recently imported kinds and a decrease in native kinds appears to have occurred.
Les actinomycétales en pathologie cutanée
Authors: Zina G. , Sartoris S. , Cervetti O.
Published: October 2009

After discussing the classification of the Actinomycétales, the authors give a detailed description of the epidemiology and particularly of the clinical features of cutaneous diseases induced by genera such as Actinomyces, Norcardia and Streptomyces. Histopathological and immunological studies, together with laboratory and differential diagnostics, are also examined. In the last section, present therapeutic treatments are briefly outlined.
Aspects électron-optiques de la thérapeutique des champignons opportunistes
Authors: Dockx P.
Published: October 2009

The ultrastructure of Aspergillus fumigatus, Aspergillus flavus and Aspergillus niger was studied when treated in vitro with 0.001, 0.01 and 0.1% econazole nitrate and econazole base. The very first morphological alterations appear faster than in normal-growing fungus and consist in a convoluted cytoplasmic membrane, large mesosomes and lomasomes and an extensive vacuolization. Acid phosphatase is found in the mesosomes and lomasomes and also in the center of the vacuoles. This is an early sign of fungus degradation.
Thérapie des mycoses opportunistes
Authors: Negroni Ricardo
Published: October 2009

The author presents the drugs that are available for the treatment of opportunistic mycoses: amphotericin B, nystatin, 5-fluorocytosine, miconazole and the newest imidazole derivative econazole. He presents his experience with econazole in 4 cases with deep mycoses. He speaks of the mode of application and the therapeutical limits of these products as well as of the favorable factors and the prophylactic measures to be taken.
Dermatotillomania
Authors: van Dijk E. , van Voorst Vader P.C.
Published: October 2009

A clinical and histopathological description is given of a number of lesions in 4 patients, mainly caused by picking at the skin. The name dermatotillomania is proposed for this group of lesions.
Antibiotic Sensitivity of Gonococcal Strains Isolated from Patients in Basel and Environs
Authors: Füllhaas J. , Vischer W.A. , Brügger P. , Rufli T.
Published: October 2009

During the first 4 months of 1977, 95 different strains of gonococcus were isolated in the out-patient department of the Dermatology Clinic of the University of Basel. These were systemically tested for sensitivity to penicillin G, spectinomycin, thiamphenicol, doxycycline and rifampicin. The MIC values and the diameter of the zones of inhibition were determined. Tests for β-lactamase production were made. A correlation in the degree of sensitivity was observed between the following antibiotics: penicillin G/rifampicin; penicillin G/thiamphenicol; penicillin G/doxycycline; thiamphenicol/doxycycline; thiamphenicol/rifampicin; doxycycline/rifampicin. The size of the inoculum had little influence on the activity of the substances, except for that of penicillin G against the β-lactamase-positive reference strains. No β-lactamase-producing strains were detected amongst the clinical isolates. In the case of penicillin G, there was a correlation between the minimum inhibitory concentration and the inhibition-zone diameter.
Vasculitis racemosa hemiplegica
Authors: Bork K. , Korting G.W.
Published: October 2009

The secondary symptomatic forms of livedo reticularis can follow cerebro-vascular incidents with consecutive hemiplegia; this is rarely known. A further patient is described who developed an asymmetrical livedo reticularis on the hemiplegic half of the body. The reason of the hemiplegia was an intracerebral hemorrhage.
Influence of the Base on the Results of Clinical Trials with Topical Corticosteroids
Authors: Vollum Dorothy I. , Sparkes C.G.
Published: October 2009

A comparative trial between betamethasone valerate and halcinonide has shown the former to be superior, thus contradicting the results from other trials. It is thought that the discrepancy is due to differences in the nature of the preparations used in the various studies. It is suggested that note is made of the base used in trials before final conclusions about the efficicacy of steroids are made.
Managing Chronic Skin Conditions with Two Differing Topical Corticosteroids
Authors: Woodbridge Peter A. , Sparkes Christopher G.
Published: October 2009

A study to demonstrate methods of using topical preparations to control chronic skin coditions is described. 25 patients with atopic eczema or psoriasis were followed for an average of 10 months. Both self-assessment using a diary card and clinical assessment were used to evaluate the treatment. The study shows that, when used correctly, topical corticosteroids can provide an effective means of controlling these intractable conditions without producing the side-effects associated with their misuse.
Twenty-One Years of Follow-Up Studies of Familial Epidermodysplasia verruciformis
Authors: Jabłońska S. , Orth G. , Jarzą;bek-Chorzelska M. , Gliński W. , Obalek S. , Rzęsa G. , Croissant O. , Favre M.
Published: October 2009

21 years of follow-up study of a family with epidermodysplasia verruciformis (e.v.) have shown that members of one family can be infected with different human papiUomaviruses (HPVs), either HPV 3 or HPV 4, and sometimes with both. The clinical picture resembled disseminated flat warts in cases induced by HPV 3, whereas in those caused by HPV 4 there were flat red or red-brownish plaques and depigmented pityriasis versicolor-like lesions. Malignancies developed only in family members infected with HPV 4, whereas the cases due to HPV 3 ran a more benign and slowly progressive or stationary course. There were also abortive and regressive cases, and the 3 children in whom the wart-like lesions did not recur after removal had an unimpaired cell-mediated immunity (CMI). In all cases of e.v., irrespective of the inducing virus, CMI was low, which seems to be an important factor in the pathogenesis of the disease. Humoral antibodies directed specifically against HPV 3 were present in the majority of the cases, mainly those infected with HPV 3.
Lymphocyte Responsiveness to Urinary Glycosaminoglycan in Systemic Scleroderma
Authors: Ishikawa Hidekazu , Hattori Akira
Published: October 2009

From the urine of patients with systemic scleroderma, we previously isolated a glycosaminoglycan, which could induce a scleroderma-like change in the skin of mouse. In the present work, the cell-mediated response to urinary glycosaminoglycans was examined by lymphocyte transformation test. The specific response was observed in lymphocytes of patients with scleroderma, when the above scleroderma-inducing glycosaminoglycan was added. By contrast, lymphocytes of patients with SLE or dermatomyositis and of normal persons hardly showed a response to this glycosaminoglycan. On the other hand, the glycosaminoglycans from normal urine could not stimulate lymphocytes of patients with scleroderma or healthy persons.
Hyperplasie angio-Iymphoïde avec mucinose folliculaire
Authors: Bovet R. , Delacrétaz J.
Published: October 2009

Association of angiolymphoid hyperplasia (pseudopyogenic granuloma type) and follicular mucinosis in the same lesion on the scalp of a 30-year-old woman. A similar case has been reported recently.
Pemphigus foliaceus in a Patient with Rheumatoid Arthritis and Sjögren’s Syndrome
Authors: Falk Edvard S.
Published: October 2009

A 74-year-old male patient with rheumatoid arthritis and Sjögren’s syndrome developed pemphigus foliaceus. Clinically healthy skin tissue revealed a fluorescent band of IgM along the basal membrane and an intercellular deposit of C3 and IgG in the deepest areas of the epidermis. Similar investigations of diseased skin revealed no deposits of IgM, and C3 and IgG were spread over a large area of the epidermis, though following the same pattern. In sero-positive rheumatoid patients with and without vasculitis, C3 and IgM are frequently found in small dermal vessels immediately below the epidermis in apparently normal skin. The fluorescent band of IgM along the basal membrane is thought to be an expression of the patient’s rheumatoid arthritis, in spite of the fact that this IgM site is not typically associated with rheumatoid arthritis. The change in the pattern of deposition is thought to be due to pemphigus foliaceus.
Werner’s Syndrome: Seven Cases in One Family
Authors: Rabbiosi G. , Borroni G.
Published: October 2009

7 cases of Werner’s syndrome in one family of northern Sardinia (the female : male ratio being 4:3) are reported. A 9-year-old girl affected with Cooley’s anemia is reported too. The typical complete pattern of the syndrome was observed in patients in the fourth decade of their lives, whereas in the two youngest ones, some features were missing. 1 patient died of gastric carcinoma, 1 of cachexia. Consanguinity was established in two generations. The genealogical tree suggests an autosomal recessive mode of inheritance. Genealogical, clinical, biochemical, and histopathological studies were performed. As far as we know, this is the largest number of patients with Werner’s syndrome reported in one family.
Palmar- und Digitalvarikose mit rezidivierenden Thrombophlebitiden
Authors: Lechner W. , Metz J. , Viehweger G.
Published: October 2009

Venectasias of palms and fingers, more or less developed, occur relatively frequently in elderly people. Other terms are palmar and digital varicosis. This abnormality is rarely observed, but it is clinically important in the case of thrombophlebitis, appearing as small, painful, palpable nodules.
Herpes Simplex Virus Isolation from Pyoderma gangrenosum Lesions in a Patient with Chronic Lymphatic Leukemia
Authors: Wahba A. , Cohen H.A.
Published: October 2009

Herpes simplex virus type 2 was isolated and identified from the vesicular border of pyoderma gangrenosum lesions on the genital region of a patient with chronic lymphatic leukemia. Dramatic relief of pain as well as quick disappearance of the vesicular margin of the lesions and of the inflammatory halo around them occurred as a result of local treatment with a solution of zinc acetate. A careful search for a viral agent should be done in every case of pyoderma gangrenosum occurring in a patient with a hematological malignancy or/and impaired immunity, especially if the lesions are on the face or in the genital region.
Low Allergenicity of Triclosan
Authors: Lachapelle J.M. , Tennstedt D.
Published: October 2009

Allergic predictive testing with triclosan (Irgasan DP 300®) has been carried out in guinea pigs and in humans in order to evaluate its potential allergenic properties. Triclosan, an antimicrobial agent increasingly used in the cosmetic industry (concentration 0.5%) has recently appeared on the market at a higher concentration (3%) in association with flumethasone pivalate as an antimicrobial and antimycotic cream (Logamel®). The results of predictive tests for allergy in guinea pigs (1 of 20 positive) and in humans (none of 20 positive) indicate that the sensitization index of triclosan is very low, which is in good accord with some reports from the literature. These underline the rarity of cases of allergic contact dermatitis to triclosan considering its widespread use in the cosmetic industry.
Drug-Induced Lymphocyte Transformation in Peripheral Lymphocytes from Patients with Drug Eruptions
Authors: Suzuki Shinsuke , Asai Yoshie , Hamada Toshio , Mizoguchi Yasuhiro , Yamada Takashi , Morisawa Seiji
Published: October 2009

In some types of drug eruptions, a positive blastoid transformation is frequently seen in peripheral lymphocytes when they are stimulated in vitro with the causative drug in the presence of autologous serum. In these cases, a soluble fraction prepared from guinea pig skin can replace the autologous serum in inducing the lymphocyte transformation, whereas either the mitochondrial or microsomal fraction of guinea pig skin instead of the autologous serum is less effective. Moreover, in fixed drug eruption, the addition of soluble skin material fractionated by gel filtration with Sephadex G-100 (FrD1 is as effective as the autologous sera in inducing lymphocyte transformation. These results suggest that the soluble fraction of skin is related to the pathogenesis of fixed and exanthematic drug eruptions as a carrier substance of drugs.
Minocycline versus Doxycycline in the Treatment of Acne vulgaris
Authors: Smit F.
Published: October 2009

16 patients with acne vulgaris were treated with either minocycline or doxycycline. Both drugs appear to have about the same effect when given for 3 months.
Photocontact Dermatitis Caused by Parthenium hysterophorus
Authors: Bhutani L.K. , Rao D.S.
Published: October 2009

A patient, possibly the first, with photocontact dermatitis due to Parthenium hysterophorus simulating actinic reticuloid is being presented.
Circulating Antigen Antibody Complexes in Scabies
Authors: van Neste D. , Salmon J.
Published: October 2009

Circulating immune complexes measured by the binding of Clq in 29 scabies patients and 52 control individuals have been found increased in the treated scabies patient.
Mitteilungen – Communications Histopathologie des hématodermies
Authors: Bonvalet D. , Belaïch S. , Civatte J.
Published: October 2009

This histologic classification is based upon the arrangement and cytologic composition of the infiltrate. We separate diseases with intraepidermal exocytosis from diseases without intraepidermal exocytosis. In the first group, mycosis fungoides is the most important: the infiltrate is often polymorphous, but sometimes it consists of histiocytes and lymphocytes. Varying number of Sézary cells are present. The Woringer-Kolopp syndrome and histiocytosis X are included in this group as well. The second group comprises many neoplastic diseases: mycosis fungoides without Pautrier microabscesses, so-called ‘reticulosis’, ‘Crosti’s reticulosis’, leukemia and lymph node lymphoma. Difficulties may arise in the differential diagnosis between these various diseases with well-differentiated lymphocytes and without intraepidermal exocytosis. These diseases must also be differentiated from the non-malignant lymphocytic infiltrates found in lupus erythematosus, lymphocytoma cutis and Jessner’s lymphocytic infiltration of the skin.
Etude immunocytologique des lymphomes cutanés malins
Authors: Souteyrand P. , Thivolet J. , Alario A. , Schmitt D. , Perrot H.
Published: October 2009

The malignant cutaneous lymphomas come into the category of hematodermias but can equally be considered as an abnormality of the immune system. Having described the methods used in the immunocytological investigation of 21 lymphomas and 3 pseudolymphomas, the authors expound their classification of malignant cutaneous lymphomas before stating the results obtained in immunocytological studies in each of the groups. They show how formal separation between epidermotropic malignant cutaneous lymphomas and non-epidermotropic malignant cutaneous lymphomas can be confirmed by immunocytological and ultrastructural facts.
La photochimiothérapie du psoriasis: expérience lausannoise
Authors: Frenk E. , Perroud H.
Published: October 2009

The results of photochemotherapy of psoriasis with oral 8-methoxypsoralen and long-wave ultraviolet light reported here are comparable to those observed in other centers using the same method of treatment. An average of 17–20 treatments was required to obtain clearing; 99–100% clearing was obtained in nearly 90% of the treated patients.
Pourquoi les lymphomes épidermotropes?
Authors: Achtent G. , de Bast C.
Published: October 2009

The clinic evolution of epidermotropic lymphomas and the analysis of recent therapeutic results demonstrate the necessity to establish an exchange between the various specialists who have to face the problems due to this disease.
Repigmentation of Hair Following Photosensitive Dermatitis
Authors: Bhutani L.K. , Minocha Y.K. , Dhir G.G. , Rao D.S.
Published: October 2009

A case of repigmentation of the scalp hair following photosensitive dermatitis is reported. The possible clinical application of this observation has been discussed.
Dapsone in the Treatment of Pemphigus Vulgaris
Authors: Haim S. , Birnbaum Friedman
Published: October 2009

This is a report on two cases with pemphigus vulgaris effectively controlled by dapsone. In one, dapsone was added to the treatment after a failure of combined prednisone and methotrexate therapy to control the disease completely. It is suggested that dapsone may offer a means in an attempt to minimize adverse reactions met with during the long corticosteroid regimen required in pemphigus.
Photocontact Dermatitis from P-Aminobenzoic Acid
Authors: Horio Takeshi , Higuchi Takako
Published: October 2009

A 6-year-old girl with xeroderma pigmentosum was contact and photocontact sensitized to PABA which had been used as a sunscreening agent. The activating wavelengths for photocontact dermatitis were in long-wave ultraviolet light. The experimental photocontact sensitization was not induced in guinea pigs. Although PABA is the most effective and harmless sunscreening agent for normal skin, it could induce photocontact sensitivity especially in diseased or damaged skin.
Deficient Phagocytic Function in Papillon-Lefèvre Syndrome
Authors: Djawari D.
Published: October 2009

The function of microphages has been studied in vitro in a 5 year-old girl with Papillon-Lefèvre syndrome. The results showed a weakness in chemotactic activity, a defect of intracellular killing of Staphylococcus aureus, and an almost normal phagocytosis but decreased intracellular killing of Candida aibicans by the microphages.
Looking Forward, Looking Back
Authors: Ong Michael K. , Mangione Carol M. , Romano Patrick S. , Zhou Qiong , Auerbach Andrew D. , Chun Alein , Davidson Bruce , Ganiats Theodore G. , Greenfield Sheldon , Gropper Michael A. , Malik Shaista , Rosenthal J. Thomas , Escarce José J.
Published: October 2009

Background—Recent studies have found substantial variation in hospital resource use by expired Medicare beneficiaries with chronic illnesses. By analyzing only expired patients, these studies cannot identify differences across hospitals in health outcomes like mortality. This study examines the association between mortality and resource use at the hospital level, when all Medicare beneficiaries hospitalized for heart failure are examined.

Methods and Results—A total of 3999 individuals hospitalized with a principal diagnosis of heart failure at 6 California teaching hospitals between January 1, 2001, and June 30, 2005, were analyzed with multivariate risk-adjustment models for total hospital days, total hospital direct costs, and mortality within 180-days after initial admission (“Looking Forward”). A subset of 1639 individuals who died during the study period were analyzed with multivariate risk-adjustment models for total hospital days and total hospital direct costs within 180-days before death (“Looking Back”). “Looking Forward” risk-adjusted hospital means ranged from 17.0% to 26.0% for mortality, 7.8 to 14.9 days for total hospital days, and 0.66 to 1.30 times the mean value for indexed total direct costs. Spearman rank correlation coefficients were −0.68 between mortality and hospital days, and −0.93 between mortality and indexed total direct costs. “Looking Back” risk-adjusted hospital means ranged from 9.1 to 21.7 days for total hospital days and 0.91 to 1.79 times the mean value for indexed total direct costs. Variation in resource use site ranks between expired and all individuals were attributable to insignificant differences.

Conclusions—California teaching hospitals that used more resources caring for patients hospitalized for heart failure had lower mortality rates. Focusing only on expired individuals may overlook mortality variation as well as associations between greater resource use and lower mortality. Reporting values without identifying significant differences may result in incorrect assumption of true differences.
Complication Rates After Left- Versus Right-Sided Carotid Endarterectomy
Authors: Girard Louis-Philippe , Feasby Thomas E. , Eliasziw Michael , Quan Hude , Kennedy James , Barnett Henry J.M. , Ghali William A.
Published: October 2009

Background—

Studies suggest that the side of carotid endarterectomy (CE) may influence the rate of postoperative complications. We sought to clarify this by (1) analysis of individual-level data from 3 large studies and (2) systematic review and meta-analysis of additional published descriptions of outcomes by side.

Methods and Results—

The Western Canada Carotid Endarterectomy (WCCE) study (n=3164) was analyzed for outcomes by side along with data from the North American Symptomatic Carotid Endarterectomy Trial (NASCET; n=1415), and the ASA [Acetylsalicylic Acid] in Carotid Endarterectomy Trial (ACE; n=2469). Pooled analysis of individual-level data from these three studies allowed calculation of rate ratios for stroke or death by side. Medline and EMBASE were searched to identify additional studies reporting CE outcomes by side, and an overall risk ratio for outcomes by side was determined with fixed-effects meta-analysis. The WCCE in-hospital stroke or death rates for left and right-sided CE were 3.72% and 3.07%, respectively (
P
=0.27). A pooled analysis of the NASCET and ACE trials also revealed higher stroke or death rates for left-sided CE (5.39% versus 2.96%;
P
<0.001). The corresponding risk-adjusted rate ratios for stroke or death for left- versus right-sided surgery were 1.22 (95% CI, 0.83 to 1.77) for WCCE and 1.82 (1.32 to 2.50) for the pooled NASCET and ACE trials. Systematic review of the literature identified 2 additional studies. Meta-analysis of all 5 available studies yielded a corresponding pooled rate ratio for stroke or death of 1.36 (1.18 to 1.56).

Conclusions—

Left-sided CE is consistently associated with higher postoperative adverse event rates. Research into potential mechanisms is required to explain and address this finding.