bluuebunny/crossref_metadata_2025 huggingface dataset:
Indomethacin Prophylaxis Is Associated with Reduced Risk of Intraventricular Hemorrhage in Extremely Preterm Infants Born in the Context of Amniotic Infection Syndrome
Authors: Hanke Kathrin , Fortmann Ingmar , Humberg Alexander , Faust Kirstin , Kribs Angela , Prager Sebastian , Felderhoff-Müser Ursula , Krüger Marcus , Heckmann Matthias , Jäger Anja , Andres Oliver , Spiegler Juliane , Härtel Christoph , Herting Egbert , Göpel Wolfgang
Published: June 2023

Background: Amniotic infection syndrome (AIS) with perinatal inflammation may increase the susceptibility to intraventricular hemorrhage (IVH) in preterm infants. Given its anti-inflammatory and ductus arteriosus constricting capacities, we hypothesized that prophylactic administration of indomethacin reduces the incidence, severity, and consequences of IVH in the context of perinatal inflammation. Methods: We evaluated data of infants born between 2009 and 2020 of 22 + 0–25+6 weeks of gestation from 68 German Neonatal Network centers. The effect of indomethacin prophylaxis on outcomes was analyzed in univariate analyses and multivariate regression models including a subgroup of infants with available data on 5-year follow-up. Results: 4760 infants were included with a median gestational age of 24.6 SSW [interquartile range (IQR) 24.1w–25.2w] and a birth weight of 640 g [IQR 550–750 g]. 1767/4760 (37.1%) preterm infants were born in the context of AIS and 527/4760 (11.1%) received indomethacin prophylaxis. AIS infants receiving prophylactic indomethacin had lower rates of IVH (32.7% vs. 36.9%, p = 0.04), IVH III/IV (9.7% vs. 16.0%, p = 0.02) and the combined outcome of severe IVH or death (15.9% vs. 23.2%, p = 0.01) as compared to infants without prophylaxis. Multivariate logistic regression analyses confirmed our observations. In a subgroup analysis of 730 preterm infants at 5 years of age, we did not find any correlation between prophylactic indomethacin and intelligence quotient <70 or cerebral palsy. Conclusions: Our observational data demonstrate that prophylactic indomethacin is associated with a reduced risk of IVH in the highly vulnerable subgroup of preterm infants <26 weeks of gestation born from AIS.
Unchanged Characteristics and Survival among Critically Ill COVID-19 Patients during First, Second, and Third Waves: A Prospective Observational Cohort
Authors: Ferré Alexis , Lamamri Myriam , Delord Marc , Abi-Abdallah Georges , Gros Antoine , Lacave Guillaume , Laurent Virginie , Marquion Fabien , Merceron Sybille , Paul Marine , Troché Gilles , Convers-Domart Raphaele , Marque-Juillet Stéphanie , Legriel Stéphane , Bruneel Fabrice ,   RESPI-COVID19 Study Group
Published: June 2023

Background: This study was carried out to compare characteristics and outcomes in patients with acute respiratory failure related to COVID-19 during first, second, and third waves. Methods: We included consecutive adults admitted to the intensive care unit between March 2020 and July 2021. We compared three groups defined by the epidemic intake phase: waves 1 (W1), 2 (W2), and 3 (W3). Results: We included 289 patients. Two hundred and eight (72%) patients were men with a median age of 63 years (IQR: 54–72), of whom 68 (23.6%) died in hospital. High-flow nasal oxygen (HFNO) was inversely associated with the need for invasive mechanical ventilation (MV) in multivariate analysis (p = 0.003) but not dexamethasone (p = 0.25). The day-90 mortality rate did not vary from W1 (27.4%) to W2 (23.9%) and W3 (22%), p = 0.67. By multivariate analysis, older age (odds ratio [OR]: 0.94/year, p < 0.001), immunodeficiency (OR: 0.33, p = 0.04), acute kidney injury (OR: 0.26, p < 0.001), and invasive MV (OR: 0.13, p < 0.001) were inversely associated with higher day-90 survival as opposed to the use of intermediate heparin thromboprophylaxis dose (OR: 3.21, p = 0.006). HFNO use and dexamethasone were not associated with higher day-90 survival (p = 0.24 and p = 0.56, respectively). Conclusions: In patients with acute respiratory failure due to COVID-19, survival did not change between first, second, and third waves while the use of invasive MV decreased. HFNO or intravenous steroids were not associated with better outcomes, whereas the use of intermediate dose of heparin for thromboprophylaxis was associated with higher day-90 survival. Larger multicentric studies are needed to confirm our findings.
Fluorescent Imaging in Visceral Surgery: Current Opportunities and Future Perspectives
Authors: von Kroge Philipp H. , Duprée Anna
Published: June 2023

Background: Fluorescent imaging using indocyanine green (FI-ICG) has become quite popular in the past century, giving the surgeon various pre- and intraoperative approaches in visceral surgery. Nevertheless, several aspects and pitfalls of using the technology need to be addressed. Summary: This article focused on the applications of FI-ICG in esophageal and colorectal surgery as this is where the clinical relevance is most important. Important benchmark studies were summarized to explain the background. In addition, dosage, the timing of application, and future perspectives – especially quantification methods – were the article’s content. Key Message: There are currently encouraging data on the use of FI-ICG, particularly concerning perfusion assessment to reduce anastomotic leakage, although its use is mainly subjective. The optimal dosage remains unclear; for perfusion evaluation, it should be around 0.1 mg/kg body weight. Moreover, the quantification of FI-ICG opens new possibilities, so that reference values may be available in the future. However, in addition to perfusion measurement, the detection of additional hepatic lesions such as liver metastases or lesions of peritoneal carcinomatosis is also possible. A standardization of FI-ICG and further studies are needed to fully utilize FI-ICG.
Isolated Proteinuria Caused by CUBN Gene Mutations: A Case Report and Review of the Literature
Authors: Ran Jingyang , Chen Qingsong , Hu Yudong , Yang Pengfei , Yu Guiquan , Liao Xiaohui , Lei Jianrong
Published: June 2023

Mutations in the cubilin (CUBN) gene commonly cause Imerslund-Gräsbeck syndrome, while isolated proteinuria as a result of CUBN variations is rarely reported. The clinical manifestation is mainly chronic isolated proteinuria in the non-nephrotic range. However, findings to date suggest that isolated proteinuria associated with abnormalities in the CUBN gene is benign and does not affect long-term prognosis of kidney function. We identified 2 patients with isolated proteinuria triggered by compound heterozygous CUBN mutations. Renal functions of both patients remained normal over a 10-year follow-up period, supporting the benign nature of proteinuria caused by CUBN gene variations. Two novel mutation sites were detected, expanding the genotypic spectrum of CUBN variations. In addition, etiology, pathogenesis, clinical manifestations, auxiliary examination, and treatment of the condition were reviewed, with the aim of providing further guidance for clinical management.
Ch´yara qullu, Tara qullu y Ch´utu: las mesas del cerro mallku Marquez en la comunidad aymara de Cobija (Chile)
Authors: Mansilla Aguilera Catalina
Published: June 2023

Con el objetivo de distinguir las mesas rituales de la comunidad aymara de Cobija como cavidades o “aberturas” (Bugallo, 2015) construidas para la recepción de dones, este artículo se centra en la descripción etnográfica de un rito de producción dedicado particularmente al cerro Marquez (Chile). El caso presentado da cuenta de que las llamadas mesas se insertan en una amplia tradición andina de ofrendas a los cerros y en un complejo y vigente acervo local referido a las ofrendas culinarias, que en este caso adquiere particular importancia en el marco de un conflicto de extractivismo minero que afectó al mallku entre 2019-2021. En términos metodológicos, este artículo es resultado de una investigación cualitativa de carácter etnográfico que se ha desarrollado desde 2015 a la fecha.
Longitudinal Lipidomic Profile of Hypertension in American Indians: Findings From the Strong Heart Family Study
Authors: Chen Mingjing , Miao Guanhong , Zhang Ying , Umans Jason G. , Lee Elisa T. , Howard Barbara V. , Fiehn Oliver , Zhao Jinying
Published: June 2023

BACKGROUND:

Dyslipidemia is an important risk factor for hypertension and cardiovascular disease. Standard lipid panel cannot reflect the complexity of blood lipidome. The associations of individual lipid species with hypertension remain to be determined in large-scale epidemiological studies, especially in a longitudinal setting.

METHODS:

Using liquid chromatography-mass spectrometry, we repeatedly measured 1542 lipid species in 3699 fasting plasma samples at 2 visits (1905 at baseline, 1794 at follow-up, ~5.5 years apart) from 1905 unique American Indians in the Strong Heart Family Study. We first identified baseline lipids associated with prevalent and incident hypertension, followed by replication of top hits in Europeans. We then conducted repeated measurement analysis to examine the associations of changes in lipid species with changes in systolic blood pressure, diastolic blood pressure, and mean arterial pressure. Network analysis was performed to identify lipid networks associated with the risk of hypertension.

RESULTS:

Baseline levels of multiple lipid species, for example, glycerophospholipids, cholesterol esters, sphingomyelins, glycerolipids, and fatty acids, were significantly associated with both prevalent and incident hypertension in American Indians. Some lipids were confirmed in Europeans. Longitudinal changes in multiple lipid species, for example, acylcarnitines, phosphatidylcholines, fatty acids, and triacylglycerols, were significantly associated with changes in blood pressure measurements. Network analysis identified distinct lipidomic patterns associated with the risk of hypertension.

CONCLUSIONS:

Baseline plasma lipid species and their longitudinal changes are significantly associated with hypertension development in American Indians. Our findings shed light on the role of dyslipidemia in hypertension and may offer potential opportunities for risk stratification and early prediction of hypertension.
The oldest aquatic aphelocheirid bug (Heteroptera, Nepomorpha) from the lower Eocene of India
Authors: PATEL RAMAN , RANA RAJENDRA SINGH , NEL ANDRÉ , ALI ASHIF
Published: June 2023

The aquatic bug family Aphelocheiridae currently comprises only the extant genus Aphelocheirus Westwood, 1833, with two subgenera, the nominal one and Micraphelocheirus Hoberlandt & Štys, 1979. The genus is widely distributed in Europe, Asia, Africa, but seems to be absent from the New World (Schuh & Weirauch, 2020). These small predatory insects live at the bottom of lakes and ponds, and breath thanks to highly specialized abdominal respiratory ‘rosettes’ characteristic of this family (Thorpe & Crisp, 1947a, b; Schuh & Slater, 1995). The closely related Naucoridae have to breathe at the surface of the water. Ye et al., 2020: fig. 4) proposed a late Triassic age for the Naucoroidea and separation between the Naucoridae and the Aphelocheiridae, but Wang et al. (2021: fig. 4) proposed that the (Potamocoridae + Aphelocheiridae) separated from the Naucoridae during the Jurassic and that the Aphelocheiridae could be early Cretaceous. The accurate aphelocheirid fossil record is very scarce, with the oldest known representative from the Eocene (Bartonian) of Germany (Moraweck et al., 2015); and a second fossil from the Pliocene of Germany (Popov, 2007; Kunzmann et al., 2017).
Begonia saxifragoides sp. nov. and two new records of Begonia (Begoniaceae) from northern Vietnam
Authors: BON TRINH NGOC , DO THI THANH HA , LE THI HANH , LO MINH DUC , ZIMMER HEIDI , LIN CHE-WEI
Published: June 2023

Surveys in montane forests in northern Vietnam have revealed one new species and two new records of Begonia. The new species, B. saxifragoides resembles B. minhaniae but is distinguished by the orbicular to reniform (vs. broadly ovate) leaves with rounded (vs. acute to acuminate) apex, the petioles densely covered with pilose or villous (vs. subappressed tomentose), ovary trigonous-globose (vs. trigonous-ellipsoid) and wings pilose or glandular hairs (vs. glabrous or sparsely tomentose). The newly recorded species from Vietnam were B. laotica Y.H.Tan & H.B.Ding previously known from Laos, and B. adscendens C.B.Clarke from India, Myanmar and Laos.
A new species of Tulostoma genus from Siberia
Authors: VLASENKO VYACHESLAV A. , VLASENKO ANASTASIA V.
Published: June 2023

We described a new Tulostoma species based on morphological and molecular data. Its characteristic features are creamy-brownish to grayish white fruiting bodies, spore-sac of small size, stem slender, gleba orange brown, spores are large, subglobose, regularly verrucose, up to 10.6 μm. Warts are large, 6–7 in number on the visible side of spore, up to 0.9 μm length, more or less isolated or merging into groups with small warts or forming ridge-like anastomoses at the base visible on SEM. It grows in scattered shrub communities with Caragana pygmaea, on dry sandy soil in south of Siberia. Based on the sequences of internal transcribed spacer (ITS1-5.8S-ITS2 = ITS) and D1/D2 domain of large subunit (28S) of nuc ribosomal DNA, we reconstructed a phylogeny of the genus Tulostoma. We present the detailed description of new species, color photos of fruiting bodies, light microscopy of anatomical characters, and analysis of morphological features in comparison with related species. To differentiate species of the genus Tulostoma necessary to use scanning electron microscopy. Therefore, we present photographs of spores of a new species under SEM. The DNA sequences obtained by us can also be used for identification of new species.
Three new species of Merma Weise (Coleoptera: Coccinellidae: Epilachnini) from Madagascar
Authors: SZAWARYN KAROL , CZERWINSKI TOMASZ
Published: June 2023

The herbivorous ladybird genus Merma Weise was regarded as an African endemite, however, recent examination of the type material of the two Malagasy species Epilachna hovana Sicard,1908 [now Merma hovana (Sicard,1908)] and Peralda quadriguttata Sicard, 1909 [now Merma quadriguttata (Sicard, 1909)], revealed they also belong to that genus. Here further three new species of Merma from Madagascar, M. ankarana sp. nov., M. antakotako sp. nov. and M. fisheri sp. nov., are described, diagnosed and illustrated. An updated key to species of Merma from Madagascar is also provided.
Quantitative Detection of the Raw Ore Turquoise Based on Laser-Induced Breakdown Spectroscopy Technology
Authors: Wu Jinquan , Wang Jian , Xiong Wei , Feng Xin , Lin Zhaoxiang
Published: June 2023

Turquoise is one of the key ingredients in some magical Tibetan medicines, and its quality and content directly affect the medicine's effectiveness. In this paper, laser-induced breakdown spectroscopy (LIBS) technology was first applied to detect the raw materials of Tibetan medicine. The traditional data analysis methods could not meet the practical requirements of modern Tibetan medicine factories due to matrix effects. The concept of correlation coefficient (ρ) in pattern recognition technique was introduced as an evaluation index, and the model was established based on the intensities of the four characteristic Al and Cu spectral lines of the samples for different contents of turquoise, which was applied to estimate the contents of turquoise in the samples to be tested. We detected the LIBS on 126 samples of raw ore from 42 areas in China and evaluated the turquoise content using self-developed software with an error of <10%. This paper's technical testing process and methods can also be applied to test other mineral compositions and provide technical support for modernizing and standardizing Tibetan medicines.
The effects of glass fiber sheet lamination on the connection strength of single-bolted pultruded glass fiber reinforced polymer profiles
Authors: Nhut Phan Viet , Quang Duc Tran , Matsumoto Yukihiro
Published: June 2023

In this study, a series of experiments and finite element analyses were conducted to investigate the effects of glass fiber sheet (GFS) lamination on the strength of pin-bearing single-bolted pultruded glass-fiber-reinforced polymer (PGFRP) connections. In the experiments, nine types of GFS lamination were molded using the vacuum-assisted resin transfer molding method (VaRTM) and bonded onto the surfaces of PGFRP members. Then, four different end distances of PGFRP plates to bolt diameters ( e/ d) were surveyed, ranging from 3 to 6. The results indicated that all types of GFS lamination offered excellent improvement effects for the ultimate loads of the PGFRP connections. The strengthening effects were better when the connections had smaller e/ d values. In addition, external 0°/90° GFSs provided the best performance for GFS-strengthened PGFRP connections with medium e/ d values. Finally, it was demonstrated that finite element analysis (FEA) could be a useful method for predicting the failure loads of GFS-strengthened PGFRP connections.
Combining DEVS simulation and ontological modeling for hierarchical analysis of the SARS-CoV-2 replication
Authors: Ayadi Ali , Frydman Claudia , Laddada Wissame , Imbert Isabelle , Zanni-Merk Cecilia , Soualmia Lina F
Published: June 2023

This article presents an hybrid and hierarchical model in which two modeling and simulation approaches, discrete event system specification simulation (DEVS) and semantic technologies, were used together in order to help in the analysis of a major healthcare problem, the severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2). Indeed, the complexity of the SARS-CoV-2 replication process, and the range of hierarchical scales over which it interacts with cellular components (extending from genomic and transcriptomic to proteomic and metabolomic scales), and the intricate way in which they are interwoven, make its understanding very challenging. It is therefore crucial to model the different scales of the replication process, by taking into account all interactions with the infected cell. By combining the advantages of both DEVS simulation and ontological modeling, we propose a hierarchical ontology-based DEVS simulation model of the SARS-CoV-2 viral replication at both the micro-molecular (proteomic and metabolomic) and macro-molecular (genomic and transcriptomic) scales. First, we demonstrate the usefulness of combining DEVS simulation and semantic technologies in a common modeling framework to face the complexity of the SARS-CoV-2 viral replication at different scales. Second, the modeling and simulation of the SARS-CoV-2 replication process on different levels provide valuable information on the different stages of the virus’s life cycle and lays the foundation for a system to anticipate future mutations selected by the virus.
Holding the Belief That Gender Roles Can Change Reduces Women’s Work–Family Conflict
Authors: Townsend Charlotte H. , Kray Laura J. , Russell Alexandra G.
Published: June 2023

Across four studies ( N = 1544), we examined the relationship between individuals’ gender role mindsets, or beliefs about the malleability versus fixedness of traditional gender roles, and work–family conflict. We found that undergraduate women (but not men) business students holding a fixed, compared to growth, gender role mindset anticipated more work–family conflict. Next, we manipulated gender role mindset and demonstrated a causal link between women’s growth mindsets (relative to fixed mindsets and control conditions) and reduced work–family conflict. We showed mechanistically that growth gender role mindsets unburden women from prescriptive gender roles, reducing work–family conflict. Finally, during COVID-19, we demonstrated a similar pattern among working women in high-achieving dual-career couples. We found an indirect effect of women’s gender role mindset on job and relationship satisfaction, mediated through work–family conflict. Our preregistered studies suggest that holding the belief that gender roles can change mitigates women’s work–family conflict.
Moving From Passion to Purpose: A STEM-Focused After-school Program’s Influence on Purpose Outcomes
Authors: Lincoln Brenna , White Allison E. , Lund Terese J. , Liang Belle , Blustein David L. , Barnett G. Michael
Published: June 2023

Despite efforts to increase diversity in STEM fields, marginalized populations—particularly women and Black and Latinx workers—remain underrepresented in STEM professions. The present qualitative study sought to explore the relationship between sense of purpose and STEM engagement within an after-school, experiential (i.e., involving hands-on learning) STEM enrichment program, called Change Makers. Specifically, semi-structured interviews with racially diverse and predominantly low SES high school students ( N = 13, 30.8% self-identified female) and their program instructors ( N = 3, 66% self-identified female) were qualitatively analyzed using a grounded theory-informed approach. Results indicate that engagement in Change Makers contributed to youth transforming their preexisting STEM interest into three purpose-related constructs: (1) self-efficacy experiences (general and specific to science), (2) increased willingness to engage in career exploration, and (3) deepened prosocial motivation. These findings underscore the value of connecting youth with experiential purpose curriculum to improve the STEM career pipeline. Finally, these findings represent insightful perspectives regarding the mutable nature of purpose development. Limitations are discussed and recommendations are made for future research and programing.
Gender and unruly titles in the booklists of the Gelasian Decree
Authors: Solevåg Anna Rebecca
Published: June 2023

This essay offers a new perspective on the booklists of the Gelasian Decree ( Decretum Gelasianium) from the sixth century. In this document’s apocryphal booklist, there are several titles featuring female or feminine names that exhibit a certain unruliness. Whether known only by title or by many titles, these entries pose the question of why female figures and texts not usually associated with heresy are constructed under this rubric in the Gelasian Decree. By untangling the lists from the academic discourse on canon and rather understanding them in the context of the document as a whole, the essay offers a fresh reading of the relations between gender, apocryphal books, and church hierarchy. Through an analysis of the occurrences of female/feminine names and signifiers throughout the text, it is found that while male figures are associated with God, the church hierarchy, and canonical and legitimate literature, the categories of apocrypha and heresy are feminized. It is argued that the “unruly” book titles in the Gelasian Degree ultimately resist the organizing efforts of its author.
Consequence analysis of heptane multiple pool fire in a dike
Authors: Nemalipuri Pruthiviraj , Singh Vasujeet , Das Harish Chandra , Pradhan Malay Kumar , Vitankar Vivek
Published: June 2023

Multiple Pool Fire (MPF) reasonably enhances the flame height, the rate of fuel combustion and irradiation due to cascading effect and flame merging of multiple pools. The distribution of temperature and radiative heat flux from the source is the key parameter in predicting safety distance. The current study’s major objective is to develop a Computational Fluid Dynamics (CFD) model to calculate the safety distance of MPF and validate the predicted results (flame temperature, radiative heat flux, CO2 and O2 mass fraction) with the experimental data. The flame structure and its thermal properties have been evaluated using the Reynolds Averaged Navier Stokes (RANS) and the Large Eddy Simulation (LES) model. The CFD results are found to be in close agreement with the experimental findings. The LES turbulence model predicts more accurately the flame structures and the fluctuations with an error of less than 3%, while the Re-Normalization Group k-ε model predicts the average characteristics. This authenticates the accuracy of computational methodology and robustness of the LES turbulence model to predict MPF flame characteristics. Furthermore, this computational methodology can be utilised by the industries for quantitative risk assessment and the worst-case scenario of various pool fires to save the human and material of the workplace beforehand.
Short-pitch corrugation formation on resilient fastener metro tracks explained using rail-bending vibrations within the bogie wheelbase
Authors: Ren Dexiang , Tao Gongquan , Li Wei , Wen Zefeng
Published: June 2023

Short-pitch corrugation is a serious problem on resilient fastened railway track for many metro lines, causing severe noise and vibration that shortens the life of the vehicle and track components. To address this problem, the formation mechanism of this kind of corrugation is investigated in this study. The corrugation characteristics and natural frequency of the resilient fastener track are determined by field investigations. Then, ‘frequency sweeping’ and long-term rail-roughness prediction models are developed to reveal the crucial role of the interactions between two wheelsets in the corrugation formation and to estimate the effects of speed variations and bogie wheelbase on corrugation growth. The spectral analysis results indicate that the spatial frequency spectrum exhibits several peaks at equal intervals due to the short-pitch corrugation of a resilient fastener metro track, which are related to the third-order rail-bending vibration within the bogie wheelbase at about 775 Hz. In addition, large and small speed variations affect the wavelength and depth growth of the corrugation, respectively. The growth of corrugation depth is amplified when the resonance frequency associated with the corrugation formation is an integer-multiple of the wheel-passing frequency. The wheelbase is also an important factor in determining the corrugation wavelength because of its influence on the resonance frequency.
Resistance to revolutionary love: The struggle to decolonise the republic
Authors: Bouteldja Houria , Younes Anna
Published: June 2023

This conversation with French-Algerian thinker and activist Houria Bouteldja focuses on her book Whites, Jews, and Us: Toward a Politics of Revolutionary Love. By zooming in on contemporary debates around racism and decolonization in France, this interview focuses on questions of how gender and masculinity, sexuality, class, and race form political relationships within the modern nation-state. In particular, it asks follow-up questions to Bouteldja's epistemology in the chapter “We, Indigenous Women,” the chapter that explicitly focuses on women, gender, and sexuality. And while gender and sexuality are always also inherently public, we follow up on tracing how her book, Les indigènes de la république (the movement of which she was the spokesperson from 2005 to 2020), and she herself have been received in French public debate, including in academia, politics and the media. Within the latter power fields, we address the role of women of color intellectuals and the challenges they pose to current debates and “moral panics” through the optics of popular decolonial movements. Eventually, a conversation unfolds where an ostensible “(too) liberal academia” has been marked by contemporary accusations of “Islamogauchisme” in a wider discourse that portrays Europe as being “in crisis” and what that means for the decolonization of Europe.
Validation of an RNAscope assay for the detection of avian influenza A virus
Authors: Gaide Nicolas , Crispo Manuela , Jbenyeni Adam , Bleuart Céline , Delverdier Maxence , Vergne Timothée , Le Loc’h Guillaume , Guérin Jean-Luc
Published: June 2023

Highly pathogenic avian influenza (HPAI) is an acute viral disease associated with high mortality and great economic losses. Immunohistochemistry (IHC) is a common diagnostic and research tool for the demonstration of avian influenza A virus (AIAV) antigens within affected tissues, supporting etiologic diagnosis and assessing viral distribution in both naturally and experimentally infected birds. RNAscope in situ hybridization (ISH) has been used successfully for the identification of a variety of viral nucleic acids within histologic samples. We validated RNAscope ISH for the detection of AIAV in formalin-fixed, paraffin-embedded (FFPE) tissues. RNAscope ISH targeting the AIAV matrix gene and anti-IAV nucleoprotein IHC were performed on 61 FFPE tissue sections obtained from 3 AIAV-negative, 16 H5 HPAIAV, and 1 low pathogenicity AIAV naturally infected birds, including 7 species sampled between 2009 and 2022. All AIAV-negative birds were confirmed negative by both techniques. All AIAVs were detected successfully by both techniques in all selected tissues and species. Subsequently, H-score comparison was assessed through computer-assisted quantitative analysis on a tissue microarray comprised of 132 tissue cores from 9 HPAIAV-infected domestic ducks. Pearson correlation of r = 0.95 (0.94–0.97), Lin concordance coefficient of ρc = 0.91 (0.88–0.93), and Bland–Altman analysis indicated high correlation and moderate concordance between the 2 techniques. H-score values were significantly higher with RNAscope ISH compared to IHC for brain, lung, and pancreatic tissues ( p ≤ 0.05). Overall, our results indicate that RNAscope ISH is a suitable and sensitive tool for in situ detection of AIAV in FFPE tissues.
Institutional Pressures and Corporate Green Innovation: Evidence From Chinese Public Enterprises
Authors: Su Ruixin , Shui Xiaolong , Du Jianguo
Published: June 2023

Although the corporate response to institutional pressures on the environmental agenda seems to be foreseeable, there is a limited understanding of the mechanisms that influence the uptake of green innovation. In this article, we examine the above question in the context of China’s green credit policy. By integrating institutional theory with resource dependence theory, a premier framework for understanding organization–environment relations, we theorize that the change in internal resource dependence is a conduit by which institutional pressures trigger corporate green innovation. This study empirically focuses on 1,485 listed Chinese firms from 2007 to 2019, during which the green credit policy was implemented in 2012. We find that the policy leads to financial constraints that stimulate corporate green innovation. Furthermore, the relationship between green credit policy and financial constraints is more significant for firms with a higher level of financial dependence on banks.
STK11 Adnexal Tumor in an Adolescent Female: Diagnostic Pitfalls of a Recently Described Entity
Authors: Sharma Aarti E. , Slack Jonathan C. , Parra-Herran Carlos E. , Quade Bradley J. , Shusterman Suzanne , Church Alanna J. , Kolin David L. , Carreon Chrystalle Katte
Published: June 2023

STK11 adnexal tumor is a recently described entity with less than 25 cases reported to date. These aggressive tumors typically occur in paratubal/paraovarian soft tissues, have characteristically striking morphologic and immunohistochemical heterogeneity, and harbor pathognomonic alterations in STK11. These occur almost exclusively in adult patients, with only one reported in a pediatric patient (to our knowledge). A previously healthy 16-year-old female presented with acute abdominal pain. Imaging studies revealed large bilateral solid and cystic adnexal masses, ascites, and peritoneal nodules. Following frozen section evaluation of a left ovarian surface nodule, bilateral salpingo-oophorectomy and tumor debulking were performed. Histologically, the tumor demonstrated distinctively variable cytoarchitecture, myxoid stroma, and mixed immunophenotype. A next generation sequencing-based assay identified a pathogenic STK11 mutation. We report the youngest patient to date with an STK11 adnexal tumor, highlighting key clinicopathologic and molecular features in order to contrast them with those of other pediatric intra-abdominal malignancies. This rare and unfamiliar tumor poses a considerable diagnostic challenge and requires a multidisciplinary integrated approach to diagnosis.
Lack of evidence for telehealth fraud
Authors: Harris Yael , Goldwater Jason C
Published: June 2023

Despite evidence to the contrary, U.S. policy makers, payers, and the public continue to express apprehension that the use of telehealth is associated with increased risk of fraud and abuse. The fraudulent use of telehealth is multifaceted and complex, ranging from potentially false claims to miscoding, inaccurate billing, and kickbacks. For the past 6 years, the U.S. Federal Government has undertaken research studies to examine potential fraud issues related to the use of telehealth, including up-coding time spent with the patient, misrepresentation of the service provided, and billing for services that were not rendered. This article reviews previous efforts to assess the risk of fraud associated with the delivery of virtual care in America, concluding that there is little evidence for higher levels of fraud and abuse related to the use of telehealth.
Pounding tuned mass damper with constrained layer damping
Authors: Duan Yaoyao , Huo Linsheng
Published: June 2023

The pounding tuned mass damper (PTMD), which is a passive vibration control device, has attracted much attention in recent years. However, due to the absence of additional dampers in traditional PTMD, the free vibration of structures cannot always be suppressed quickly. Another limitation for the traditional PTMD is that the primary structure is subjected to a large pounding force that may cause local damage and fatigue. To address these limitations, this paper proposes a novel PTMD with constrained layer damping (CLD-PTMD) by attaching a damping layer and the constraining layer to the surface of the stiffness element of the PTMD to provide more damping. In the experiment, the influence that the different configuration parameters have on the damping performance of CLD is examined. A shake table test is conducted to investigate the energy dissipation of a CLD-PTMD subjected to harmonic excitation. The FEM model of the CLD beam is established to determine the damping ratio and analyze more parameters. The CLD-PTMD is used for the vibration control of a simulated SDOF structure. The results demonstrate that compared with the traditional PTMD, CLD dissipates more energy than the pounding process. In addition, CLD-PTMD has a lower pounding force and pounding energy than PTMD in free and forced vibration. The free vibration with CLD-PTMD can be suppressed faster. The robustness of CLD-PTMD is better and the control performance of CLD-PTMD is more stable than traditional PTMD.
Emerging molecular biomarkers in osteoarthritis pathology
Authors: Sandhu Amit , Rockel Jason S. , Lively Starlee , Kapoor Mohit
Published: June 2023

Osteoarthritis (OA) is the most common form of arthritis resulting in joint discomfort and disability, culminating in decline in life quality. Attention has been drawn in recent years to disease-associated molecular biomarkers found in readily accessible biofluids due to low invasiveness of acquisition and their potential to detect early pathological molecular changes not observed with traditional imaging methodology. These biochemical markers of OA have been found in synovial fluid, blood, and urine. They include emerging molecular classes, such as metabolites and noncoding RNAs, as well as classical biomarkers, like inflammatory mediators and by-products of degradative processes involving articular cartilage. Although blood-based biomarkers tend to be most studied, the use of synovial fluid, a more isolated biofluid in the synovial joint, and urine as an excreted fluid containing OA biomarkers can offer valuable information on local and overall disease activity, respectively. Furthermore, larger clinical studies are required to determine relationships between biomarkers in different biofluids, and their impacts on patient measures of OA. This narrative review provides a concise overview of recent studies of OA using these four classes of biomarkers as potential biomarker for measuring disease incidence, staging, prognosis, and therapeutic intervention efficacy.
Barriers to physical activity of stroke survivors in Singapore: A face-to-face cross-sectional survey
Authors: Teo Raylynn , Thilarajah Shamala , Jiale Liu , Yu Favian Lim Fang , Khim Kwah Li
Published: June 2023

Background

Physical activity (PA) levels of stroke survivors are far from recommended levels. To develop specific interventions targeted at improving PA after stroke, there is a need to consider the barriers to PA faced by stroke survivors.

Objective

To use the comprehensive Barriers to Physical Activity Questionnaire for People with Mobility Impairments (BPAQ-MI) to identify intrapersonal, interpersonal, organizational and community barriers to PA faced by stroke survivors in Singapore.

Methods

We conducted a face-to-face survey with stroke survivors recruited from Singapore National Stroke Association platforms. Participants were eligible for the study if they were 21 years old and above, had a medical diagnosis of stroke, and had a weak arm or leg.

Results

38 stroke survivors participated in the survey. More than half had moderate or moderately severe disability, and needed assistance for activities of daily living or walking. Of the 63 barriers spanning across intrapersonal, interpersonal, organizational and community domains, the top three most commonly reported barriers include lack of accessible classes/programs at fitness centre (21/38; 55%), lack of assistance from fitness centre staff (19/38; 50%) and feelings of tiredness/fatigue (18/38; 47%). Of the top 10 most commonly reported barriers, four were organizational barriers, four were intrapersonal barriers and two were community barriers.

Conclusions

Stroke survivors in Singapore want to participate in PA, but are often limited by barriers associated with fitness centres, self and the environment in the wider community.
Unusual presentation of orbital compartment syndrome due to complicated herpes zoster ophthalmicus: A case report
Authors: Peñarrieta-Daher Edgar A , Herrera-Gutiérrez Raúl , Marcos-Ramírez Edson R , Tolentino-González Christian S , Garcia-Garza Jorge A , Cervantes-Kardasch Victor Hugo , Castro-Govea Yanko
Published: June 2023

Herpesvirus reactivates from a latent infection in older adults and critically ill and immunocompromised individuals. Herpes zoster ophthalmicus (HZO) is a latent infection that affects the fifth cranial nerve. It is an infrequent cause of increased intraocular pressure. We present the case of a 50-year-old man with a reactivation of latent varicella-zoster virus infection involving the ophthalmic branch of the fifth cranial nerve. The patient was initially managed as an outpatient with an antiviral, but his clinical evolution worsened and required urgent surgical decompression. Lateral canthotomy was performed with cantholysis of the inferior crus of the lateral canthal tendon. Only partial decompression was achieved, so cantholysis of the upper crus was performed with significant tissue tension release. The patient evolved well and was discharged after 6 days without symptoms for outpatient management.
Social Prescribing Initiative at Community Library and Its Impact on Residents and the Community: A Qualitative Study
Authors: Morimoto Yoichi , Koga Yayoi , Kenzaka Tsuneaki , Son Daisuke
Published: June 2023

Introduction/Objectives:

Social prescribing aims to improve health and well-being by connecting individuals with mental health, housing, and loneliness issues to informal services and support. This approach connects individuals to activities and services in their community to fulfill their practical, social, and emotional needs. However, no reports of community libraries being prescribed as a place to be referred through social prescribing were observed in the literature and the impact of community libraries on community residents and communities in social prescribing. The aim of this study was to identify the functions of a community library operated by medical and social professionals in the social prescribing initiative, its functions, and its impact on community residents and communities.

Methods:

Semi-structured interviews were conducted with the users of the Daikai Bunko Library, a community library in Toyooka City, Japan. The library was established by a primary care physician and community residents as a place where visitors can stay and use it as a library, a bookstore, a café, and a consultation place. Interviews were recorded, and the verbatim transcript was analyzed using the Steps for Coding and Theorization.

Results:

Ten individuals participated. The theoretical description of the interview texts revealed 11 categories as the function of the library and its effect on the individuals and the community: a place to stay, attractive space design, diverse accessibility, choosability of various roles, consultation function, social support, empowerment, mutual trust, formation of connections across generations/attributes, co-creation, and social impact.

Conclusions:

We found that a community library run by medical and social professionals was a useful social prescribing site and had various effects on the community residents who used it. Various functions of the community library, such as consultation functions and attractive space design, may lead to effects on local individuals providing social support and empowerment, with social impacts such as co-creation and formation of connections to the local community.
The Influence of Social Marketing Drives on Brand Loyalty via the Customer Satisfaction as a Mediating Factor in Travel and Tourism Offices
Authors: Al-Dmour Rand , Alkhatib Ola H. , Al-Dmour Hani , Basheer Amin Eatedal
Published: June 2023

This study analyzed the impact of various aspects of social media marketing (beneficial promotions, relevant content, popular content, and presence on multiple platforms) on brand loyalty through the mediating factor of customer satisfaction in travel and tourism offices in Jordan. The study’s sample consisted of 350 followers of at least one travel and tourism office on social media, with a response rate of 86% obtained via a self-administered questionnaire. The results supported the significance of social media marketing drives on brand loyalty, with customer satisfaction playing a crucial mediating role. All the factors that engage customers in social media marketing (i.e., beneficial promotions, relevant content, popular content, and presence on multiple platforms) were found to have a simultaneous impact on brand loyalty. This study is the first of its kind in the Jordanian business setting to examine the effect of social media marketing on brand loyalty through customer satisfaction. Most prior research in this field has been conducted in Western countries.
A Mixed Methods Study of Contraceptive Counseling and Care at a Federally Qualified Health Center in Maryland
Authors: Hart Leah , Parsons Georgia , Beaudoin Jarett , Alonge Olakunle , Karp Celia
Published: June 2023

This study examined the experience of contraceptive counseling and care in a Federally Qualified Health Center in Maryland. Patients attending medical visits in 2021 were surveyed using the Interpersonal Quality of Family Planning scale to assess the quality of contraceptive counseling. Medical chart reviews were performed to identify alignment between contraceptive care received, and preferences patients had expressed. Primary care providers, reproductive health providers, and a subgroup of patients were interviewed to further contextualize survey and chart review findings. The average item score for the 94 survey participants was 4.39 (SD: 0.9) out of 5. Factor analysis showed high internal consistency reliability (alpha  =  0.96). Eighty percent of patients received contraceptive care that aligned with their preferences, 4% did not, and 16% lacked clear contraceptive preferences. Qualitative analysis revealed that patients desired more guidance from providers in selecting a contraceptive method, while providers noted logistical and insurance-related barriers to care. While the quality of contraceptive counseling was high, patient experience of care may be improved by implementing team-based care.
Compact structured light generation based on meta-hologram PCSEL integration
Authors: Hsu Wen-Cheng , Chang Chia-Hsun , Hong Yu-Heng , Kuo Hao-Chung , Huang Yao-Wei
Published: June 2023

Metasurfaces, a catalog of optical components, offer numerous novel functions on demand. They have been integrated with vertical cavity surface-emitting lasers (VCSELs) in previous studies. However, the performance has been limited by the features of the VCSELs such as low output power and large divergence angle. Although the solution of the module of VCSEL array could solve these issues, the practical application is limited by extra lens and large size. In this study, we experimentally demonstrate reconstruction of a holographic images using a compact integration of a photonic crystal surface-emitting laser and metasurface holograms designed for structured light generation. This research showcases the flexible design capabilities of metasurfaces, high output power (on the order of milliwatts), and the ability to produce well-uniformed images with a wide field of view without the need for a collection lens, making it suitable for 3D imaging and sensing.
Evaluation of clinical effects of a multidisciplinary-collaborated cancer support team for gastrointestinal cancer chemotherapy: prospective observational study protocol of M-CAST study
Authors: Iimura Yohei , Nakazawa Mitsuko , Tsuru Yukari , Togashi Hitomi , Honda Tomoe , Baba Keisuke , Ishibashi Masaaki , Sasuga Chieko , Furukawa Naoki , Sato Tomoko , Matsubara Yasuo , Kamisato Ayako , Yoshii Eiko , Kuroda Seiichiro , Boku Narikazu
Published: June 2023

Background

Although the multidisciplinary-collaborated team approach in cancer treatment has recently become popular, prospectively evaluated evidence is limited. We started a multidisciplinary-collaborated cancer support team (MCST) to facilitate cooperation across multidisciplinary medical staff in our hospital and established clinical evidence of supportive care. This study aimed to prospectively evaluate the clinical activity and effect of MCST in patients with gastrointestinal cancer receiving chemotherapy.

Methods

This is a single-center, single-arm, observational study. Patients with gastrointestinal cancer scheduled to receive chemotherapy are enrolled and supported by the MCST. The primary endpoints are the number of interventions by medical staff and the number of patients who showed improvement in side effects. The secondary endpoints are the severity of side effects, medical expenses, number of consultations, the acceptance rate of prescription recommendations, adjuvant chemotherapy completion rates, dose intensity, and time required for co-medical intervention. In addition, medical staff and attending physicians evaluate all adverse events.

Discussion

This study is expected to contribute to establishing new cancer-supportive care teams for patients with gastrointestinal cancer receiving chemotherapy and those with cancer receiving chemotherapy.

Trial registration

This trial was registered in the Japan Registry of Clinical Trials (jRCT) as jRCT1030220495.

The date of first registration, 29/11/2022, https://jrct.niph.go.jp/search