bluuebunny/crossref_metadata_2025 huggingface dataset:
PRODUCTION OF BETULA PENDULA POLLEN Bet v 2 ALLERGEN WITH IMMUNOREGULATORY SIGNALS AND ITS RECOGNITION BY IgE ANTIBODIES
Authors: Ryabova N L , Kuzmenko Y V , Tyutyaeva V V , Andreev I V , Sankov M N , Starodubova E S , Preobrazhenskaya O V , Martynov A I , Karpov V L
Published: July 2021

Background. Creation of recombinant proteins, containing profilin and signal peptides which provide proteasomal and lysosomal degradation pathways of proteins. Materials and methods. Plasmid pET-Bet v 2, encoding Bet v 2 allergen, was used as a base vector. Two signal peptides: C-terminal fragment of ornithine decarboxylase (ODCsig) and N-terminal fragment of human invariant chain (Ii) — were cloned into this vector. Recombinant proteins were produced in BL21 (DE3) strain of E. coli. The recombinant protein was purified using NiNTA agarose. Immunological specificity of the recombinant proteins was estimated by means of immune-enzyme methods using sera of patients suffering from birch pollen allergy. Results. Bet v 2 allergen (profilin) of Betula pendula pollen was modified by immunoregulatory peptides in order to change the IgE/IgG response ratio. Ornithine decarboxylase proteasome degradation signal was used to enhance the Th1 response and human invariant chain signal directed to lysosomes was used in order to enhance Th2 response. The production system of recombinant allergen Bet v 2 preparation suitable for immunological tests was developed. The produced highly purified chimeric proteins preparations bound IgE antibodies of allergic to birch pollen patients' sera efficiently. Conclusion. The new chimeric allergens based on Bet v 2 protein of Betula pendula pollen were created and isolated.
NETHERTON SYNDROME
Authors: Revyakina V A , Timofeeva A M , Monosova O Y , Kuvshinova E D
Published: July 2021

The article presents the clinical case of the rare genetic disease Netherton syndrome occurring under the guise of various diseases, including allergies. the etiology of this disease is unknown diagnostics is complicated.
CHLOROPYRAMINE: EFFICACY AND SAFETY, APPROVED IN PRACTICE
Authors: TSAREV S V
Published: July 2021

This article presents data about the importance of chloropyramine in the treatment of allergic diseases and acute respiratory viral infections.
DRUG ALLERGY. RECOMMENDATIONS FOR CLINICIANS (PART 2)
Authors: Ilina N I , Latisheva T V , Myasnikova T N , Luss L V , Kurbacheva O M , Erokhina S M
Published: July 2021

Recommendations contain modern data about incidence, etiology, patogenesis, diagnostics and treatment of drug allergy.
THE ROLE OF NEBULIZED BECLOMETHASONE DIPROPIONATE IN THE TREATMENT OF BRONCHIAL ASTHMA
Authors: Avdeev S N
Published: July 2021

Beclomethasone dipropionate (BDP, Clenil UDV) is a well-studied inhaled corticosteroid for the treatment of patients with bronchial asthma (BA). Randomized controlled trials have shown that nebulized therapy with BDP was similar in its efficacy and safety to inhalation therapy with budesonide or fluticasone. Preferred patients for the treatment with nebulized BDP are elderly patients with asthma, unable to correctly perform inhalation with portable devices, patients with steroid-dependent asthma, and patients with a temporary loss of asthma control.
Skin care products for sensitive skin
Authors: Filimonova T M , Shtyrbul O V , Fedenko E S
Published: July 2021

This article deals with skin care of sensitive, irritated skin. Application of the daily basic skin care products improves the effectiveness of treatment and quality of life of patients with sensitive skin.
FAMCICLOVIR IN THERAPY OF ATOPIC DERMATITIS PATIENTS WITH HERPES SIMPLEX INFECTION
Authors: Zuikova I N , Shulzhenko A E , Fedenko E S , Elisutina O G
Published: July 2021

The prevalence of herpes simplex virus in different age groups, the high frequency of relapsing forms of infection, torpid course, postherpetic complications are relevant medical and social problems. Often, practitioners create significant difficulties in establishing the diagnosis, choice of strategy in patients with herpes simplex. The paper presents the methods of diagnosis of herpes simplex and their application in atopic dermatitis patients, issues of acyclic nucleoside therapy (acyclovir, famciclovir) in different clinical forms of herpes simplex with individual approach to the selection of an antiviral drug and patterns of use.
Preparation and properties evaluation of the recombinant analogue of birch pollen allergen Bet v 1
Authors: Pavlov A E , Seylieva N A , Mukhortykh O YU , Stefanov V E
Published: July 2021

Background. For wide introduction of the component allergy diagnostics in laboratory practice it is necessary to create methods of production, purification and verification of synthetic allergens. Major birch pollen protein Bet v 1, a representative of the superfamily PR-10, is interesting due to the high incidence of sensitization and the manifestation of cross-reactive properties. Methods. To receive a synthetic protein DNA cloning techniques were used, followed by expression in E. coli. Purification was made by metal-affinity chromatography. Evaluation of immunochemical properties was held in several tests including ELISA analysis and line-blot. Results. We have obtained high-yield bacterial strain E. coli, containing expression vector for protein Bet v 1 production. Physico-chemical and immunological properties were estimated in various test systems with the reference panel of serum. Conclusion. It was shown that the resulting synthetic analogue of protein Bet v 1 can be used to measure the presence of specific immunoglobulin E in serum samples. This allergenic component may be used for estimation of each component of the sensitization profile.
PRODUCTION AND CHARACTERIZATION OF RECOMBINANT PROTEINS CONTAINING BET V 2 ANTIGENIC EPITOPES OF BETULA PENDULA
Authors: Chernysheva A V , Tyutyaeva V V , Pivovarova A V , Andreev I V , Sankov M N , Kuzmenko Y V , Starodubova E S , Martynov A I , Karpov V L
Published: July 2021

Aim of investigation. Production of immunologically active recombinant protein of Bet v 2 allergen ofbirch pollen. Materials and methods. mRNA was isolated from a sample ofbirch pollen. cDNA library was derived using SMART technology. Gene Bet v 2 was amplified by means of PCR with primers from the cDNA. The resulting PCR fragment of the gene was cloned into the vector pET29b(+). The recombinant protein Bet v 2 was expressed in cells E. coli, transformed with a plasmid. The recombinant protein was purified using NiNTA agarose. Immunological activity of the recombinant protein Bet v 2 was measured by ELISA and immunoblot methods. Results. The production system of the recombinant allergen Bet v 2 preparation suitable for immunological tests was developed during the research project. In the first phase allergen Bet v 2 gene was cloned from birch pollen collected in Russia. The gene was inserted into the vector pET29(+) for expression in bacterial cells. The expression cell strain E. coli was obtained with this plasmid. The synthesis of the recombinant protein that accumulates in inclusion bodies was activated in bacterial cells. The procedure of recombinant protein Bet v 2 isolation from inclusion bodies was developed by one round of chromatography purification. The recombinant protein isolation was carried out by chromatography on Niagarose. The highly purified preparation of the recombinant allergen was obtained as a result. The recognition of the recombinant protein Bet v 2 by sera varied in ELISA, indicating a different degree of patients sensitization to this allergen. In the immunoblot test the preparation was active only in 15% of cases. Apparently, reactive epitopes of the allergen are mainly conformational ones and are active in ELISA test, whereas linear epitopes, that are active in immunoblot, are in the minority. Conclusion.The system for production of recombinant allergen Bet v 2 preparation suitable for immunological tests has been developed.
Group of Investigators for ERAs Program, Russia. Allergic rhinitis and asthma in real clinical practice in Russia: multicenter clinical study
Authors: Emelyanov A V , Goryachkina L A , Astafeva N G , Fassakhov R S , Chernyak B A , Abelevich M M , Ignatova G L , Kudelia L M , Zhestkov A V , Leschenko I V , Sobko E A , Alexeenko V A , Burlachuk V T , Lobanov K I , Frolova S A , Galimova E S , Khassanova R B , Koroleva M G
Published: July 2021

The aim of the study which included 2311 patients (aged 18—80 yrs), examined by 100 physicians (57% allergists, 37% pulmonologists and 7% general practitioner) in 18 Russian cities, was to assess the prevalence of allergic rhinitis in patients with asthma, as well as to evaluate the specifics of the course of these diseases, when concomitant or not. The study design included one outpatient visit, followed by the completion of studyspecific case report forms and Asthma Control Questionnaire (ACQ) validated for use in Russia. The vast majority (88%)of asthma patients had concomitant allergic rhinitis (Group 1). Patients with asthma only (Group 2) were older (50,6±0,78 vs 41,9±0,35 yr, p
Improvement of control methods of treatment of mycoplasma infection in children with bronchial asthma
Authors: Geppe N A , Krylova N A , Rakovskaia I V , Gorina L G , Barkhatova O I , Goncharova S A , Levina G A , Utiusheva M G
Published: July 2021

Background. Improvement of control methods of treatment of mycoplasma infection in children with bronchial asthma. Methods. 52 children from 1 to 4 years old with bronchial asthma who had mycoplasma antigens in the blood were examined before treatment of mycoplasma infection, 15 patients were examined in 1,5 months after treatment. Reaction of aggregate-hemagglutination, immunofluorescence assay and the reaction of the polymerase chain reaction (PCR) were used for detection of mycoplasmas’ antigens and DNA. Results. In reaction of aggregate-hemagglutination Mycoplasma pneumoniae (Mpn) was detected in 65,4% of patients, Mycoplasma hominis (Mh) — in 32,7%, Ureaplasma urealyticum — in 50%, Mycoplasma arthritidis — in 46,2%, Mycoplasma fermentrans — in 46,2%. In more detail, we investigated Mpn and Mh. Antigens of Mpn and Mh were detected in serum significantly frequently than DNA by PCR. DNA in structure of circulating immune complexes (CIC) was detected more often than in free state. After treatment by azithromycin the number of positive tests on antigens and DNA in free state and in structure of CIC decreased. In most cases DNA found in serum of blood in free state and in structure of CIC belongs to persistent living cells of mycoplasma. Conclusion. Empowering diagnosis of mycoplasma infections in asthma in children allows to base a comprehensive approach to laboratory diagnosis, monitor treatment, predict disease course.
BRONCHIAL ASTHMA. WHAT IS IT POSSIBLE TO DO FOR ACHIEVEMENT OF CONTROL OF THIS DISEASE?
Authors: Kurbacheva O M
Published: July 2021

Bronchial asthma is the disease extended around the world, having optimized medical approaches to which maintaining, it is possible to reduce it’s influence on the patient and society. Approaches applied now to a cumulative assessment of asthma burden are unreliable: doctors underestimate real weight of a disease at the patients receiving antiasthmatic therapy, and patients overestimate extent of control of the disease. However, control of bronchial asthma can be reached with treatment according to the modern recommendations. Article is devoted to some aspects of the combined anti-inflammatory therapy of bronchial asthma by various pharmacological means and their combinations.
Clinical and pathogenetic aspects of bronchial asthma with mycotic sensitization among residents of Siberia, Yakutia and the Russian Far East
Authors: Lazutkina E L , Muzychenko L M , Landyshev Yu S , Tsyrendorzhiev D D , Chaplenko T N
Published: July 2021

Background. Is to investigate clinical and pathogenetic features of bronchial asthma (BA) in residents of Siberia, Yakutia, and Russian Far East with mycotic sensitization. Materials and Methods. 45 BA patients in the age group of 24—58 year-olds have been checked. Among them 245 patients were residents of Amur region, 112 patients — residents of Novosibirsk region, and 86 — of the Republic of Yakutia (SAHA), the City of Mirniy. All the patients went through a complex clinical and allergological checkup. The results were processed with «STATISTICA 6» set of programs. Results of the research. Variation in mycotic sensitization in BA patients has proved to be region-bound. Conclusion. Mycotic sensitization in BA patients is marked by predominantly severe clinical course of bronchial asthma and high levels of IgE in the patients’ serum. In the Republic of Yakutia (SAHA) the number of such patients is higher than in Amur and Novosibirsk regions. In BA patients — residents of Amur and Novosibirsk regions — mycotic allergy is accompanied by the domestic one, while in Yakutia it is observed along with epidermal sensitization.
Some aspects of maintaining patients with primary immunodeficiencies with antibodies synthesis disfunction. Data on 10% intravenous immunoglobulin G Gamunex treatment
Authors: Latysheva E A , Setdikova N H , Latysheva T V
Published: July 2021

On time diagnostics and correct treatment of patients with PID with humoral deficiency provide a good prognosis. Despite of long experience of intravenous immunoglobulins (IVIG) usage for the treatment of these patients no strict recommendations concerning regimes of treatment exist. This article presents clinical experience about the treatment with 10% IVIG Gamunex in PID patients with immunoglobulin deficiency.
THE EFFICIENCY OF LEVOCETIRIZINE IN TREATMENT OF ALLERGIC SKIN DISEASES
Authors: Elisyutina O G , Fedenko E S , Fedoskova T G , Luss L V
Published: July 2021

In the article the results of supervision over the patients with chronic urticaria (n=32) and atopic dermatitis (n=30), at the age from 2 till 55 years old treated with H^blocker levocetirizine, are presented. High clinical efficiency and safety of levocetirizine treatment of allergic skin diseases were confirmed.
Local and systemic immune response in patients withsevere atopic dermatitis
Authors: Filimonova T M , Elisyutina Ol'ga Gur'evna , Fedenko E S , Niyazov D D , Boldyreva M N , Burmenskaya O V , Rebrova O Yu , Filimonova T M , Elisyutina O G , Fedenko E S , Niazov D D , Boldyreva M N , Burmenskaya O V , Rebrova O Yu
Published: July 2021

Background. to comparatively investigate cytokine gene expression in the skin and peripheral blood of atopic
dermatitis (AD) patients and healthy individuals.
Methods. Samples of skin and peripheral blood from 48 severe AD patients SCORAD (Scoring Atopic Dermatitis)
78,5 [57; 89], IGA (Investigators Global Assessment) 4,2 [3,9; 4,7]) at the age of 17 to 45 years and 20 healthy donors
aged from 19 to 32 years were analyzed for gene expression of cytokines using real time reverse transcription
polymerase chain reaction (RT-PCR).
Results. In the skin of patients with AD, a significant increase of the level of gene expression was observed for
interleukin IL2R (interleukin) (р=0,0023), IL5 (р=0,002), IL6 (р=0,0023), IL8 (р=0,01), IL12β (р=0,0023), IL10
(р=0,0023), IL23 (р=0,002), IL29 (р=0,0023), and TGFβ (transforming growth factor) (p=0,0023) as compared to
healthy individuals. In contrast, no difference between AD patients and healthy donors was detected with respect
to cytokine gene expression in the peripheral blood.
Conclusions. Activity of IL-2R, IL-8, IL-12β, IL-23, IL-29, and TGFβ that are markers of chronic inflammation
and Th1 immune response in severe AD and IL-5, IL-10 that are anti-inflammatory cytokines and markers of
Th2 response was predominant in the skin but not in the blood of AD patients.
Bronchial asthma «masks» are not always easy to recognize.Case report
Authors: Isakova I I , Pol'ner S A , Gushchin I S , Isakova I I , Polner S A , Gushchin I S
Published: July 2021

Clinical case of Churg-Strauss syndrome was described in 36-year old female patient in the course of its
development since the disease suggested start. Churg-Strauss syndromes manifestations were characterized
by high peripheral blood eosinophilia and multiple organ lesions, here include airways, heart (exudative
pericarditis), and skin (urticaria). The prescribed therapy involved cytostatic agents and pulse therapy with
glucocorticoids slowly reducing up to maintaining dose. In the course of the therapy a stable clinical disease
remission was registered. Maximally fast diagnostics of the given syndrome provides immediate start of therapy
and holds up autoimmune process. Both contribute to significant decrease of cases with severe forms and possible
complications.
Regulat ory T-cells in periphera l blood of pat ientswith br onchial ast hma
Authors: Kremer E E , Kirillova N A , Teplova N V , Deev I A , Petrova I V , Ogorodova L M , Kremer E E , Kirillova N A , Teplova N V , Deev I A , Petrova I V , Ogorodova L M
Published: July 2021

Background. To investigate the expression of surface molecules CD4+CD25high and CD4+FoxP3+ on regulatory
T-cells (Treg) in patients with different severity of bronchial asthma (BA).
Methods. We included 19 patients with severe BA, 12 patients with mild BA and 17 healthy donors. The circulating
percentage of CD4+CD25high and CD4+FoxP3+ T-reg in peripheral blood was estimated by the flow cytometry
analysis (FACSCalibur, Becton Dickinson, USA).
Results. Numbers of peripheral blood CD4+CD25high was significantly decreased in mild BA compared to healthy
control. Patients with severe BA had increased levels of CD4+FoxP3+ and CD4+CD25high compared to mild BA.
Conclusion. Our results demonstrate new scientific data on the phenotypic characteristics and the level of T-reg
in peripheral blood at different clinical forms of asthma. This fact confirms the existence of immunoregulatory
control mechanisms of allergic inflammation involving T-reg.
Clinic al and immunologic al characteristic ofinfants with atopic dermatitis
Authors: Ivanova Natal'ya Aleksandrovna , Kuz'mina G A , Kochish L T , Begaeva N N , Afanas'eva N M , Ivanova N A , Kuzmina G A , Kochish L T , Begaeva N N , Afanasyeva N M
Published: July 2021

Background. The research is focused on the particularities of formation and course of atopic dermatitis in infancy
depending on the range of sensitization and class of revealed antibodies.
Methods. The article presents the results of clinical and immunological observation of 116 children aged from
1 month to 3 years with the clinical-anamnestic signs of atopic dermatitis. The immunological observation consisted
of the following stages: determination of concentration of the general IgE, quantitative testing of concentrations
of the serum IgE and IgG4 antibodies to allergens of cow and goat milk, chicken eggs and wheat, house dust and
through the immune-enzyme analysis.
Results and discussion. According to the results of the immunological observation the patients were divided into
3 groups: I - IgE+IgG4 - positive, II - IgG4 - positive, III - absence of above-mentioned classes of antibodies.
The patients of group I are characterized by the early sensitization to cow milk proteins, the manifestation of
the disease up to 3 months appears on pure breast feeding. The detection of the specific IgE antibodies to allergens
of chicken eggs is a sign of danger of the development of sensitization towards inhalation house dust
allergens and of the formation of respiratory allergy. For the children of group II the later age of manifestation
of skin process (in more than half of children after introduction of milk food) and easier course of disease are
significant. Anamnesis of the disease and the clinical manifestations of one third of patients of group III in the
absence of the evidence of IgE-sensitization coincides with that of the patients of group I (age of manifestation,
severity of disease). In accordance with received results, we can suggest that in this group there are patients with
the unidentified immunopathological mechanism of formation of the disease.
Conclusion. The immunological observation of infants by the detection of the specific IgE and IgG4 antibodies
to widespread food allergens allows to reveal the peculiarities of immune response which in their turn define
the clinical-anamnestic signs of atopic dermatitis.
DECLINE DYNAMICS OF STAHPYLOCOCCUS AUREUS SUSCEPTIBILITY TO ANTIBIOTICS IN CHILDREN WITH ATOPICDERMATITIS
Authors: Treneva M S , Pampura A N , Zaporozhtseva Z V , Treneva M S , Pampura A N , Zaporozhtseva Z V
Published: July 2021

Background. Staphylococus aureus (S. aureus) colonization is revealed in 87-90% patients with atopic dermatitis
(aD). S. aureus antibiotic susceptibility differs within time. the study is aimed to investigate the dynamics of
S.aureus susceptibility to antibiotics and time limitation of this process in children with aD.
Methods. S. aureus susceptibility to 19 antibiotics was analyzed with 72 resistance patterns (31 initial and 41 repeated
in 0,5-30 months) of 203 performed in 647 children with aD tested in 2007-2009 years.
results. in a three year period (2007-2009) a negative correlation of S. aureus antibiotic susceptible strains prevalence
versus months since initial pattern was revealed (R=−0,29 p
Use of Broncho-Munal after measles vacc ination inkids with recu rrent infections
Authors: Kharit S M , Nacharova E P , Kaplina S P , Monakhova N E , Goleva O V , Kharit S M , Nacharova E P , Kaplina S P , Monahova N E , Goleva O V
Published: July 2021

Abstract: 15 kids (1-3 years old) with recurrent infections received therapy with Broncho-munal (1 capsule/day)
from the day 1 till the day 30 after measles vaccination. The control group of 29 kids of the same age did not
receive any immunomodulatory therapy after the vaccination. 12 out of 15 (80%) kids in the Broncho-munal
group developed no complications after the vaccination compared with 20 out of 29 kids (68,9%) in the control
group. The frequency of intercurrent infections was 3,5 times lower in the Broncho-munal group. The kids in
the Broncho-munal group developed neither lymphopenia nor leukopenia. They had increased counts of CD25+
and CD20+ cells by the day 30 after the vaccination, prolonged production of the specific antibodies as well as
higher geometric mean titers of the anti-measles antibodies on the day 45 after the vaccination. Taken together
these observations suggest that Broncho-munal protected from the transitory immunosuppressive effects of
the vaccination.
CHARACTERISTICS OF ANTENATAL AND POSTNATAL RISKFACTORS OF FOOD ALLERGY IN INFANTS
Authors: Denisova Svetlana Nikolaevna , Belitskaya M Yu , Sentsova T B , Kon' I Ya , Kirillova O O , Denisova S N , Belitskaya M Y , Sentsova T B , Kon` I Y , Kirillova О О
Published: July 2021

Aim. to analyze a family history of the allergic diseases, course of pregnancy and delivery in mothers, effect of
concomitant diseases on the development and course of food allergy in infants.
methods. We examined 471 infants with food allergy and different severity index of the atopic dermatitis (AD).
Moderate and severe AD were more common at the age of 0-12 months old than at the age of 12-36 months old
(80,9 and 55,6%, respectively). in boys of the 12-36 months severe course of the disease was more common then
in girls at the same age (14,6 and 7,3%, respectively). We used SCORAD index for estimation of severity of AD.
Results. positive family histories of the allergic diseases were revealed in 67,9 and 67,3% of the infants with
moderate and severe course of AD, respectively. in the half of these infants allergic diseases were found in the
maternal line. Disturbances of the pregnancy and delivery in mothers of the infants with and without AD were
equal; however these disturbances were more common in mothers of the infants with severe AD. the postnatal
risk factors of allergy were revealed in 11,7% of infants: prematurity (3,2%), prenatal hypotrophy (4,7%), intranatal
asphyxia (2,3%), cephalohaematoma (1,5%).
Conclusion. the positive family history of allergy was high in all infants with AD independently on the age of
the appearance of first signs of food allergy. Mothers with pathological course of pregnancy and delivery more
often had an infants with severe course of AD. prevalence of the postnatal risk factors in healthy and ill infants
was equal.
ТREATMENT AND PREVENTIVE ACTION OF NASAL SPRAY NAZAVAL IN THE ALLERGIC RHINITIS PATIENTS. CLINICAL RESEARCHES REVIEW
Authors: Il'ina N I , Kurbacheva Oksana Mikhaylovna , Mikeladze K P , Pavlova K S , Shvets S M , Ilina N , Kurbacheva O , Mikeladse K , Pavlova K , Shvets S
Published: July 2021

The mechanism of action and efficiency of Nazaval representing a powder of natural cellulose, new to the Russian pharmaceutical market, creating barrier on a way of contact of allergen with a nose mucous membrane is considered. Clinical efficiency of a preparation at adults and children with a seasonal and perennial rhinitis is shown. Preventive action of Nasaval was developed in provocation tests with allergen.
NEW FEATURES OF THE PHARMACOLOGICAL CONTROL OF ASTHMA
Authors: Nazarova E V , Il'ina Nataliya Ivanovna , Nazarova E V , Ilina N I
Published: July 2021

traditionally, bronchial asthma (Ba) was considered as a disease of large and medium bronchi, but recently
obtained convincing evidence that inflammation in asthma captures the distal parts of the lower respiratory tract.
several studies have proved that the peripheral respiratory ways, including the lung tissue itself, are the principal
place of airflow obstruction in patients with asthma. there are currently actively being developed devices for
improving the delivery of anti-inflammatory drugs on the periphery of the lung, to improve asthma control.
ТHE EFFICIENCY AND SAFETY OF CALCINEURIN INHIBITORS (TACROLIMUS) IN ATOPIC DERMATITIS AND OTHER DERMATOLOGICAL DISEASES
Authors: Ochelenko S A , Monakhov K N , Ochelenko S A , Monakhov K N
Published: July 2021

The problems of clinical efficiency and safety of application of tacrolimus (Protopik) at various skin diseases are discussed in this review. High efficiency of this drug, allows to use it in treatment of different dermatosis. The clinical effect is comparable with topical corticosteroids, and the rate of adverse effects is lower. It is possible to use long applications of calcineurin inhibitors in patients with resistant forms of atopic dermatitis. Positive effects of application of tacrolimus in vitiligo, balanitis, alopecia areata etc. are described.
The efficiency of non-specific inhaled immunotherapy with ruzam in patients with atopic bronchialasthma
Authors: Terekhov D V , Nenasheva Nataliya Mikhaylovna , Terekhov D V , Nenasheva N M
Published: July 2021

Background. To study the efficacy and safety of inhaled form of ruzam in adult patients with persistent mild
and moderate atopic bronchial asthma (ba).
Materials and methods. a placebo-controlled prospective, randomized, open label study of an efficacy of ruzam
a solution for inhalations (in bottles on 2,5 or 5 ml) on 2,5 ml onсe a day through nebulizer during 2 weeks was
conducted in adult asthmatic patients. The efficacy of therapy was evaluated by dynamics of symptoms and requirement
in 2-agonists, besides PEfr, spirometry, bronchial hyperresponsiveness (bhr), asthma control test
(aCT ), level of the markers of the allergic inflammation were performed.
Results. reduction of bа symptoms, increase morning PEfr, decrease of bhr and NОex level in patients who
received ruzam compared with control group was observed. achievement of clinical control of bа in patients
treated by ruzam was accompanied by statistically significant positive dynamics of markers of inflammation
(ifNg, ECP) in blood serum and in supernatant of the induced sputum. it testifies about anti-inflammatory influence
of ruzam.
Conclusion. inhaled therapy with ruzam in a complex with iNCs basic therapy is an effective and safe method
of treatment of persistent atopic bronchial asthma. This combination allows to reach clinical and functional
control of ba faster and to reduce inflammation markers in blood serum and induced sputum.
Multidrug resistance gene (MDR1) - marker of therapeutic resistance and severity of disease
Authors: Mironova Z A , Trofimov V I , Simakova M A , Iantchina E D , Dubina M V
Published: July 2021

Genes polymorphism is known to be one of the causes of the inadequate response to drugs or drugs resistance. In the most of cases drugs influence depends on interaction of several products of genes expression, which influence on drugs pharmacokinetics and pharmacodynamics.
Present article concerns the review of publications and results of original investigations concerning the multidrug resistance gene (MDRl) expression associations with P-glycoprotein-170 (Pgp-170) expression in different diseases and the role of Pgp-170 in distribution of drugs in tissues.
Immunological alterations i n patients with atopicdermatitis
Authors: Gevorkyan O V , Ospelnikova T P , Ershov F I
Published: July 2021

This review is dedicated to analysis of immunological alterations in patients with atopic dermatitis, one of the most common allergic dermatosis, and includes data about the role of cytokines and interferon system in pathogenesis of this disease.
ASSOCIATION OF IL5, CCL26 AND CCL5 GENE POLYMORPHISMSWITH ATOPIC BRONCHIAL ASTHMA
Authors: Voronko O E , Dmitrieva-Zdorova E V , Latysheva E A , Aksenova M G , Storozhakov G I , Bodoev N V
Published: July 2021

The purpose of the work. In order to investigate whether single nucleotide polymorphisms С(-703)Т in IL5
gene, T(+2497)G in CCL26 and A(-403)G in CCL5 gene contribute to atopic bronchial asthma development
we performed a comparative analysis of alleles and genotypes frequencies of these polymorphisms in Russian
patients from Moscow region.
Materials and methods. DNA samples from 283 patients with atopic bronchial asthma and 227 healthy donors
were genotyped.
Results. There were associations neither of С(-703)Т in IL5 gene, T(+2497)G in CCL26 and A(-403)G in CCL5
gene with asthma nor with asthma severity.
Conclusion. Therefore, we may conclude that genes responsible for activation and chemotaxis of eosinophils play
an insignificant role in susceptibility to development of atopic bronchial asthma, and probably may influence
indirectly specific processes that occur in asthma.-
Multiple faces of bronchial asthma
Authors: Fedoseev G B , T rofimov V I , Fedoseev G B , Trofimov V I
Published: July 2021

The analysis of publications and results of original investigations concerning the pathogenesis and clinical course
of bronchial asthma is performed. B ronchial asthma is a markedly heterogeneous disease, the heterogeneity
is due to the differences in severity cause, phases, clinical pathogenetic variants, associations with the other
allergic diseases, COP D, diseases of other organs, influence of different allergens and infectious agents. T hus, the effective treatment plan should be based also on attention to individual features of the patient and include
both drugs and methods of non-drug treatment.
Recurrent upper respiratory tract infections and immune defi-ciency in children
Authors: Yartsev M N , Plachtienko M V
Published: July 2021

The lecture is devoted to results of clinical and immunological investigation of 614 children with 20 forms of primary immunodeficiency states and more than 8000 children with «frequent infections». The observations were performed in children unit of the Institute of Immunology in the years 1981-2010. The main features of primary immunodeficiency and secondary immunodeficiency and the term «immunocompromised child» are analyzed in details.
Histafen antihistaminic and sedative effects in patients with chronic recurrent urticaria
Authors: Luss L V , Tuzlukova E B , Grebenchenko E I
Published: July 2021

The purposes of the study. The primary purpose was to show antihistaminic efficiency of Histafen in a daily doze of 150 mg per os within 14 days at patients with chronic urticaria (ChU) on an example of suppression of the skin reaction caused by histamin. The secondary purposes: To estimate a condition of microcirculation in the skin of patients with ChU during Histafen treatment and to confirm safety and absence of sedative effect of Histafen. Materials and methods of study. There were 20 adult patients (men and women) in the age from 18 to 55, with exacerbation of ChU included in the study; 20 healthy persons - as a control group. We made clinic and laboratory examination to all patients, including skin pricktitration with histamin, research of local microcirculation in a skin. Sedative effect estimated on the change of stability of attention by means of B. Burdon's proof test and volume of attention by Shulte tables.
Results. Histafen suppression of the skin urticaria and hyperemia which was caused by histamine in ChU patients was established: for 50% and 40% respectively. However these results are statistically doubtful - p=0,27 and p=0,18 respectively. The revealed changes of local microcirculation in the skin can testify to normalization of basal blood-groove parameters in skin of patients with ChU. Absence of sedative effect during of Histafen treatment was established: absence of statistically approved changes in parameters of volume of attention (p=0,6) and authentic improvement of stability of attention after the treatment (p=0,01) was noted. The conclusion. The study demonstrated high antihistaminic activity of Histafen, its safety and absence of sedative effect in patients with ChU.
FEATURES OF DIET THERAPY IN INFANTS WITH POLYVALENTFOOD ALLERGY
Authors: Pampura A N , Varlamov E E
Published: July 2021

Background. Establish indications for prescription of amino acid formula to infants with atopic dermatitis.
Methods. 55 infants with atopic dermatitis and food allergy were enrolled. Allergic examination included skin
prick tests and evaluation of specific IgE level. Oral challenge test was performed if necessary.
Results. Low efficacy of elimination diet was observed in 16 infants with multiple food protein intolerance. In the issue cluster analysis defined two subgroups. High IgE levels, specific IgE to egg and fish were considered as criterions of the first subgroup.
Patients with multiple food protein intolerance and low efficacy to elimination diet received amino acid formula, SCORAD index decreased more than 50% after the first week of treatment.
Conclusion. Multiple food protein intolerance is particular form of food allergy. Prescription of amino acid
formula is reasonable in this category of patients.
KAHANDAAN NG MGA GURO NA NAGTUTURO NG ASIGNATURANG FILIPINO SA PAGGAMIT
NG GOOGLE CLASSROOM
Authors: Rachel D. Buenviaje
Published: July 2021

Ito ang lagom, ang mga natuklasan, ang konklusyon at rekomendasyon na kaugnay sa Kahandaan ng mga Gurong Nagtuturo ng Asignaturang Filipino sa Paggamit ng Google Classroom sa Laguna State Polytechnic University Taong Panuruan 2020-2021. Ang mga datos sa nasabing pananaliksik ay galling sa labing-isa (11) guro mula sa iba’t ibang kolehiyo ng nasabing unibersidad upang bigyang kasagutan ang mga inilatag na katanungan ng mananaliksik.. Deskriptibong disenyo ng pananaliksik ang ginamit sa pag-aaral at sa pamamagitan ng frequency at percentage upang malaman ang simpleng pagbilang sa bawat sagot sa mga tanong, sa pagkuha ng antas ng kahandaan ng mga guro na nagtuturo ng Asignaturang Filipino sa paggamit ng google classroom, paggamit ng Uri ng Dulog sa Panitikan at Wika ay gagamitin ang Mean at Standard Deviation at Multiple Regession para malaman ang epekto ng profayl ng mga guro, kahandaan ng mga Guro na Nagtuturo ng Asignaturang Filipino sa paggamit ng google classroom, paggamit ng uri ng Dulog sa Panitikan at Wika.
Ang Estado ng Profayl ng mga Guro Una, Edad, nakakuha ng bilang pito (7) ang nasa edad na 29 gulang pababa . Pangalawa ang Kasarian marami ang bilang ng mga gurong lalaki na may bilang na anim (6) sinundan ng mga gurong babae na may bilang na (5) Pangatlo, Kolehiyong kinabibilangan nakakuha ng pantay na bilang ang “College of Arts and Sciences” at “College of Teacher Education” na may bilang, Pang-apat, Taon ng Pagtuturo pinakamataas ang 1 hanggang 5 taon na bilang na 8.
Ang antas ng kahandaan ng mga guro na nagtuturo ng Asignaturang Filipino sa paggamit ng google classroom batay sa Personal na Kamalayan, Kawilihan, Aksesibiliti, Pagsasanay, Talakayan at Takdang-Aralin ay kapwa nakakuha ng ganap na sumasang-ayon at literal na paliwanag na lubhang mataas.
Ang antas ng Paggamit ng uri ng Dulog sa Panitikan batay sa Pamamaraang Tanong-Sagot, Pamamaraang Paulat, at Pagkatutong Interaktibo ay kapwa nakakuha ng ganap na sumasang-ayon at literal na paliwanag na lubhang mataas.
Ang antas ng Paggamit ng Uri ng Dulog sa Wika batay sa Pamamaraang Pabuod at Pamamaraang Panayam ay kapwa nakakuha ng ganap na sumasang-ayon at literal na paliwanag na lubhang mataas.
May makabuluhang epekto ng Profayl ng mga guro sa paggamit ng Uri ng Dulog sa Panitikan at sa Wika.
May makabuluhang epekto ng kahandaan ng mga guro na nagtuturo ng asignaturang Filipino sa Paggamit ng google classroom batay sa Paggamit ng Dulog sa Panitikan at Wika.
Ang resulta sa nasabing pananaliksik ay sumasalamin an lubhang katanggap-tanggap ang paggamit ng aplikasyong Google Classroom sa pagtuturo sa Asignaturang Filipino ng mga Guro mula sa unibersidad ng Laguna State Polytechnic University.
Inererekomenda ng mananaliksik na ang mga guro ay patuloy na dumalo sa mga palihan tungkol sa paggamit ng google classroom upang pag-ibayuhin pang ganap ang pagkatuto nila nito.
PENGGUNAAN APLIKASI FIGMA DALAM MEMBANGUN UI/UX YANG INTERAKTIF PADA PROGRAM STUDI TEKNIK INFORMATIKA STMIK TASIKMALAYA
Authors: Rully Pramudita  , Rita Wahyuni Arifin  , Ari Nurul Alfian  , Nadya Safitri  , Shilka Dina Anwariya
Published: July 2021

Keberadaan UserInterface (UI) dan User Experience (UX) Designer semakin dibutuhkan beberapa waktu belakangan. Salah satu alasannya karena banyak perusahaan yang mulai menggunakan platform mobile dan situs untuk perkembangan bisnis. Dalam menjawab tantangan ini maka pengetahuan mengenai UI/ UX diperlukan dalam hal melakukan perancangan program, hal ini pun sejalan dengan salah satu tujuan dari profil Prodi S1 Teknik Informatika STMIK Tasikmalaya yaitu; Menghasilkan tenaga ahli di bidang Teknik Informatika yang unggul, terampil menggunakan TIK serta memiliki pengetahuan pendukung yang relevan dengan jenis pekerjaan yang ditanganinya. Kemampuan penguasaaan teknologi dan informasi khususnya kepada mahasiswa semester 3 dari Program Studi Teknik Informatika dalam penguasaan konsep desain UI/UX sangat diperlukan. Melalui kegiatan PkM yang dilaksanakan secara online melalui zoom meeting dan live www.youtube.com, dan diperoleh hasil melalui kuesioner respon balik dari peserta mengenai tingkat kepuasan sebanyak 50% merasa puas, 38,1% merasa puas sekali, dan 11,9% merasa cukup puas dengan adanya PkM ini. Dengan demikian diharapkan mahasiswa dapat meningkatkan wawasan dan kompetensi untuk dapat bersaing pada masa indutri 4.0 ini.

 Kata kunci—figma, pengabdian masyarakat, ui/ux, user experience, user interface.

The existence of UserInterface (UI) and User Experience (UX) Designer has been increasingly needed in recent times. One of the reasons is because many companies are starting to use mobile platforms and websites for business development. In answering this challenge, knowledge of UI / UX is needed in terms of conducting program design, this is also in line with one of the goals of the S1 Informatics Engineering Study Program profile, STMIK Tasikmalaya, namely; Producing experts in the field of Information Technology who are superior, skilled in using ICT and have supporting knowledge that is relevant to the type of work they handle. The ability to control technology and information, especially for 3rd semester students of the Informatics Engineering Study Program, in mastering the UI / UX design concept is needed. Through PkM activities carried out online through zoom meetings and live www.youtube.com, and results were obtained through questionnaire responses from participants regarding the satisfaction level of 50% being satisfied, 38.1% very satisfied, and 11.9% feeling quite satisfied with this PkM. Thus, it is hoped that students can increase their insight and competence to be able to compete in this industrial era 4.0.

Keywords— community service, figma, ui/ux, user experience, user interface.
Pelatihan Kelompok Ibu-Ibu Anggota Koperasi CMS Tangerang Selatan dalam Membuat Kukis dari Ubi sebagai Alternatif Kudapan Sehat yang Bisa Dijadikan Peluang Usaha
Authors: Gayatri Askardiya Mirza , Muzdalifah Muzdalifah , Adi Tony Margiyanto
Published: July 2021

Kegiatan pengabdian kepada masyarakat ini bertujuan untuk memberikan pengetahuan, motivasi, dan pelatihan keterampilan bagi ibu-ibu anggota Koperasi CMS di Tangerang Selatan. Musibah banjir yang melanda di beberapa wilayah di Indonesia termasuk di Jabodetabek, membuat kita prihatin. Bersumber dari informasi melalui media baik cetak maupun elektronik, para korban banjir terutama anak dan lansia mendapatkan makanan dan kudapan yang kurang layak serta kurang bergizi, untuk itulah tim pengabdian kepada masyarakat Universitas Indraprasta PGRI yang berjumlah 2 dosen dibantu oleh satu mahasiswa akan membantu merealisasikan keinginan mitra yang seharusnya berjumlah 25 orang menjadi 15 orang (dikarenakan kesibukan mitra bersamaan dengan tugasnya sebagai ibu dalam mendampingi anak-anaknya sekolah melalui daring) untuk meningkatkan kepedulian kepada korban banjir yang salah satunya dengan membuat kudapan sehat dari ubi berupa kukis atau kue kering. Metode yang digunakan dalam pelaksanaan kegiatan ini adalah diawali dengan pemberian pengetahuan tentang kewirausahaan dan motivasi via video dikarenakan masih dalam suasana PSBB akibat pandemi Covid-19. Dilanjutkan dengan praktik langsung membuat kudapan sehat dari ubi yang dikemas secara kekinian melalui video. Bahan baku dari ubi mengedukasi masyarakat supaya mengetahui bahwa ubi bisa menjadi kudapan sehat dan tahan lama juga tampilannya sangat kekinian. Bentuk luarannya mitra mendapatkan pengetahuan kewirausahaan di bidang kuliner, bisa membuat produk kudapan sehat dari ubi berupa kukis atau kue kering, meningkatkan kepedulian melalui kudapan/ makanan sehat.
Pelatihan Memanfaatkan Limbah Rumah Tangga Menjadi Barang yang Bernilai Ekonomis pada Kelompok Karang Taruna di Balekambang, Jakarta Timur
Authors: Juniawaty Rudeva , Juriah Siti , Herwati Kanaria
Published: July 2021

Abstrak
Tujuan dari kegiatan pengabdian kepada masyarakat ini untuk memberikan pelatihan keterampilan dalam memanfaatkan limbah rumah tangga menjadi barang yang bernilai ekonomis dan layak untuk dipasarkan. Pelatihan dilakukan pada Kelompok Karang Taruna RT 003 RW 05 Kelurahan Balekambang, Condet, Jakarta Timur. Adapun target rencana kegiatan ini adalah salah satu dari tridarma perguruan tinggi yaitu pengabdian kepada masyarakat. Metode yang digunakan oleh Tim Dosen Universitas Indraprasta dalam kegiatan ini adalah dengan memberikan pelatihan keterampilan dengan cara mempresentasikan dan kegiatan praktik langsung dengan mengajarkan beberapa keterampilan membuat aneka hiasan dan barang-barang yang diaplikasikan dengan kain flanel sehingga dapat memiliki nilai ekonomis kepada 10 (sepuluh) remaja Karang Taruna RT 003/05 Kel. Balekambang Kec. Kramat Jati, Jakarta Timur sebagai bekal untuk berwirausaha kelak.
Pendampingan Sistem Pembelajaran Online Menggunakan Fitur Annote pada Aplikasi Zoom di TK Dzakra Lebah Madu
Authors: Utami Fitria Budi , Nuryeti Nuryeti , Rahayu Yeni , Salamah Robiatus , Agustini Tita , Putri Widya Erliana
Published: July 2021

Tujuan kegiatan pengabdian pada masyarakat ini adalah untuk mengatasi kegelisahan mitra dalam menghadapi situasi pembelajaran online pada masa pandemi Covid-19 di TK Dzakra Lebah Madu. Di mana banyak guru di TK Dzakra Lebah Madu masih belum maksimal dalam memanfaatkan aplikasi Zoom dalam proses pembelajaran. Untuk itu, melalui pemberdayaan guru dengan memanfaatkan fitur Annote pada aplikasi Zoom diharapkan mampu menjadi sarana kegiatan yang akan mengoptimalkan proses kegiatan belajar mengajar meskipun tidak adanya tatap muka. Selain itu, target yang ingin dicapai melalui kegiatan ini adalah guru dapat lebih kreatif dan bersemangat dalam mendampingi anak-anak belajar dari rumah dengan memanfaatkan fitur Annote pada aplikasi Zoom. Metode kegiatan ini berupa praktik langsung, diskusi dan pendampingan dengan  guru melalui kegiatan mini-workshop. Setelah diberi materi tentang pemanfaatan fitur Annote pada Zoom dalam kegiatan belajar di rumah, selanjutnya guru dibimbing untuk mengimplementasikannya. Dengan kegiatan ini, guru menjadi lebih kreatif dalam mengampaikan materi dan juga bersemangat karena merasa terbantu dalam proses belajar dan mengajar dari rumah. Dengan demikian diharapkan potensi anak dapat terasah dengan baik meskipun kegiatan belajar dilakukan di rumah.
Yûnus Emre'nin Dîvân'ında Perde Metaforu
Authors: DİLMEN Ömer
Published: July 2021

Kur’ân-ı Kerim’de ve hadîs-i şerîflerde çeşitli metaforik anlamlarda kullanılan hicâb/perde kavramı, sûfîler tarafından da aynı amaçla kullanılmıştır. Sûfilere göre bu kavram, daha çok Hak ile kul arasındaki engeller şeklinde ele alınmıştır. Hicâb/perde kavramı, tasavvuf düşüncesinde varlık anlayışı açıklanırken kullanılan önemli kavramlardan biridir. Kul için önemli olan Hakk’a ulaşmaktır. Kulun Hakk’a ulaşmasına engel olan her ne varsa perdedir. Yûnus Emre’nin Dîvân’ında bu kavram daha çok Hakk’a perde olma anlamında kullanılmıştır. Bu anlamın yanı sıra beyitlerde; ilmin hakîkate perde olması, dünyanın perde olması, Cebrâil’in perdelenmiş olması, insanın kendine perde olması, ibadetlerin perde olması, gayb perdesi, hesap günü perdesi, sabır perdesi gibi anlamlarda da bu kavramın kullanıldığı görülmektedir.
Yûnus’a göre; Hakk’ı görmek, ikilikten kurtulmak, vahdete ulaşmak için perdelerin kalkması gerekir. Bu da ancak mânevî eğitimle, aşkla gerçekleşir. En kalın perde nefs perdesidir. İnsanın perdeleri aralaması, nefsini terbiye ederek kendi varlığından kurtulması ile mümkündür. Yûnus’a göre dünya hayatı ve zâhirî ilimler de perdedir. Burada Yûnus, araçların amaç haline getirilmesinin tehlikesine dikkat çeker. Hesap gününde perdelerin kalkacağına işâret etmekle Yûnus, sonsuz hayatı insanların gündemine sokmak ister. Kulun çabası ile perdelerin açılması nasıl bir nimetse, hesap günü Hakk’ın perdeleri kaldırması ile hakîkatin âşikar olması da küfrân-ı nimette bulunan kullar için zorlu bir sürecin başlangıcı olacaktır.
Peran Guru Dalam Penerapan Nilai-Nilai Ta’lim Al-Muta’allim Dalam Pembelajaran Di MTSN Plandi Jombang
Authors: Sunardi
Published: July 2021

Menurut Ali Syafe‟i Manusia adalah makhluk yang tertinggiderajatnya yang diciptakan Tuhan yang terbaik, terhormat, mulia,individu, sosial, makhluk bumi pengemban amanat. Sejalan denganketinggian dan kerendahan manusia dalam menjaga kelansungan danpotensi hidupnya agar tidak mati atau menjadi liar, maka perludilakukan pembinaan dan bimbingan terhadap potensi yang dimilikinyaagar dapat berkembang dengan benar dan terarah. Oleh karena itu,pendidikan merupakan alternatif penting manusia untuk membinapotensinya. Sementara posisi guru dalam pembelajaran merupahansebagai transper ilmu pengetahuan (knowledge oriented) danketrampilan (skill oriented), namun juga berorientasi pada nilai (vulesoriented). Proses pembelajaran yang menekankan pada nilai-nilai(kejujuran, keharmonisan, saling menghargai, dan kesetaraan) adalahhal yang tidak disampingkan, apalagi dilakukan. Jenis Penelitian inimenggunakan penelitian lapangan (field reasearch) dan menggunakanpendekatan kualitatif yang bersifat deskriptif, dengan rancangan teknik