bluuebunny/crossref_metadata_2025 huggingface dataset:
Dapagliflozin efficacy as an add-on therapy in double and triple-drug regimens: A meta-analysis of randomized control trial
Authors: Saikia Deepjyoti. , Chathamvelli Akash , Fernandes Lizanne , Patil Kadambari , Aswathi A , Mahajan Pooja , Nyamagoud Sanatkumar
Published: January 2023

Background: Diabetes is one of the most common diseases compared to others. There are many drugs available in the market to treat diabetes. Still, most of them have adverse drug reactions like hypoglycemia, weight gain, and subtherapeutic drug concentrations. SGLT-2 inhibitors are a new class of drugs used as add-on therapy to treat type-2 Diabetes Mellitus. They act by inhibiting glucose reabsorption and increasing glucose excretion via the kidneys. In an average adult, two kidneys filter about 180g of glucose per day. About 98% of the glucose filtered in the kidneys get reabsorbed in the proximal convoluted tubule back into the bloodstream, which can be inhibited by SGLT-2 inhibitors.

Method:  A systematic review and meta-analysis were performed on randomized clinical trial data, extracted from PubMed, Cochrane and Embase. All data, including baseline and shift of baseline, standard deviation, and number of participants, were recorded for HbA1c, Fasting blood glucose (FBG), Bodyweight and SBP/DBP.

Results: Twelve randomized clinical trials, including 8000 participants, were compared and divided into three groups of drugs: SAXA+DAPA+MET, SAXA+MET and DAPA+MET. The comparison is done for HbA1c (WMD:-6.78; 95% CI:-8.28; P <0.00001) (WMD:-4.88; 95% CI:-6.93; P <0.00001), FBG (SMD: -6.50; 95% CI: -8.55, -4.45; P <0.00001) (SMD: -7.75; 95% CI: -8.84, -6.66; P<0.00005,), body weight (SMD: 0.30; 95% CI: 0.27, 0.33; P =1.00) (SMD: -1.00; 95% CI: -1.90, -0.10; P<0.00001). Conclusion: Dapagliflozin, when given in combination, shows a major improvement in HbA1c and FBG levels and does not affect body weight. It was shown to be more effective when given in triple combination therapy.

Keywords: Dapagliflozine, meta-analysis, Sexagliptine, Metformin, Type two diabetes mellitus (T2DM), Sodium-glucose Cotransporter-2 (SGLT2)
Application of Artificial Intelligence and Machine Learning in Drug Discovery and Development
Authors: Parvathaneni Madhukiran , Awol Abduselam K. , Kumari Monika , Lan Ke , Lingam Manisha
Published: January 2023

Drug discovery has traditionally been a time consuming and expensive endeavor. Additionally, drugs weren’t as effectively designed as those that are being predicted and developed through AI and ML today. Machine learning is a form of artificial intelligence that develops and evolves based on experience (similarly to the human mind), and is more recently being utilized in drug discovery and design. The integration of AI and ML into the drug discovery and development process has allowed for higher target precision, lower toxicity, and better dosage formulations. AI more generally has been introduced to and has been leveraged at, each step of drug development, including target identification and validation, hit identification, as well as hit to lead optimization, and has been key in shortening the previously lengthy drug screening process. AI and ML has also been applied downstream in drug formulation where it has maximized resource utilization and is allowing for web-based 3D printing of drugs. Application of AI in the drug development process has also been extended to the modeling of novel drug-like compounds to predict their ADMET properties. This review will address the stages of drug discovery and development in which the application of AI and ML modeling has altered the traditional development of drugs.

Keywords: Drug discovery, machine learning, artificial intelligence, computational drug development.
Evaluation of the antioxidant potential and phytochemical analysis of Terminalia mantaly and Terminalia ivorensis two plants of the Ivorian pharmacopoeia
Authors: Kipré Gueyraud Rolland , Agré Don Josette , Djyh Bernard Nazaire , Ouattara Lacinan , Joseph Djaman Allico
Published: January 2023

The neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis are characterized by a significant increase in oxidative stress that can lead to cellular damage to neurons. In recent years, the antioxidant activity of medicinal plants has become important in research against cancer and neurodegenerative diseases.

Terminalia mantaly and Terminalia ivorensis are two plants traditionally used to treat lesions, wounds, ulcers and hemorrhoids, malaria and yellow fever. In the present work, we evaluated the antioxidant power and determined the secondary metabolites contained in these two plants.

The results show that Terminalia mantaly and Terminalia ivorensis have a good antioxidant activity.

They can be studied in the search for drugs against neurodegenerative diseases such as Alzheimer's disease.

Keywords : Alzheimer's disease, Neurons, Parkinson's disease, Terminalia ivorensis and Terminalia mantaly
Habb-e-Azaraqi, A Potent Unani Pharmacopoeial preparation used in Neurological disorder: A review
Authors: Bano Saba , Usmani Qamrul Islam , Aleem Mohd
Published: January 2023

Unani medicine relies on drugs of natural origin for the treatment of various medical conditions. It is practised throughout Asia and particularly in India. The rich natural drug asset of Unani medicine includes both single and compound drugs. Habb-e-Azaraqi is a polyherbal Unani formulation used clinically since decades for the management of various neurological disorders like facial palsy, paralysis, gout and arthritis. The explicit nature of Habb-e-Azaraqi rationalizes its use in nervine disorders. The main ingredient of Habb-e-Azaraqi is Azaraqi mudabbar (detoxified Strychnos nux-vomica L.) which is known for its diverse medicinal uses. This review highlights the traditional uses of Habb-e-Azaraqi, phytochemistry and pharmacological properties of its ingredient.

Keyword: Habb-e-Azaraqi; Facial palsy; Paralysis; Strychnos nux-vomica; Unani medicine
Personal Financial Well-being of Family Medicine Residents and Residency Curricula: A CERA Study
Authors: Ellwood Stephanie , Weathers Jamie , DeMello Jim , Graves Lisa , Antoun Jumana , Soares Neelkamal
Published: January 2023

Introduction: Personal financial wellness is a milestone in graduate medical education. Prior surveys addressing financial wellness have not included family medicine (FM) residents and to date, no literature has explored the relationship between perceived financial well-being and personal finance curriculum in residency. Our study aimed to measure the financial well-being of residents and its association with the delivery of financial curricula in residency and other demographics.
Methods: Our survey was included in the Council of Academic Family Medicine Educational Research Alliance (CERA) omnibus survey sent to 5,000 FM residents. We use the Consumer Financial Protection Bureau (CFPB) financial well-being guide and scale to measure financial well-being and categorize into low, medium, and high ranges.
Results: Two hundred sixty-six residents (response rate of 5.32%) responded with a mean financial well-being score of 55.7 (SD 12.1), in the medium score range. Financial well-being was positively associated with any form of personal financial curricula in residency, year in residency, income and citizenship. Most residents 204 (79.1%) agreed/strongly agreed that personal financial curricula are important to their education, and 53 (20.7%) never received personal financial curricula.
Conclusions: Personal financial well-being scores of family medicine residents are considered medium per the CFPB ranges we assigned. We find a positive and significant association with the presence of personal financial curricula in residency. Future studies should evaluate the effectiveness of different formats of personal finance curriculum in residency on financial well-being.
Progressively decreased functional coupling within task positive networks during acute stress signals stress resilience: the promotion role of reward system
Authors: Li Yizhuo , Liu Yadong , Zhao Xiaolin , Ren Yipeng , Wei Zhenni , Xia Suping , Zhang Mengjie , Yang Zijian , Yang Juan
Published: January 2023

Over the past decade, studies have demonstrated that a shift in
attentional patterns from goal-oriented top-down attention to bottom-up
attention to external stimuli under acute stress involve reallocating
resources between different neurocognitive networks，which is a
heterogeneous process. However, it remains unclear that how this neural
functional coupling regulates the activation and termination of
hypothalamic-pituitary-adrenal (HPA) axis, the major endocrine stress
system. To bridge this konwledge gap, seventy-seven participants (age,
17–22 years, 37 women) were recruited for a ScanSTRESS brain imaging
study, and their salivary cortisol levels during stress were collected.
In addition, we assessed individual differences in the sensitivity of
behavioral activation system (BAS) and funtional connectivity of the
brain in all participants. We found that functional couplings among the
dorsal attention network (DAN), central executive network (CEN) and
visual network (VN) decreased significantly during repeated stress
induction. The decline of functional connectivity could single a rapid
cortisol recovery and the level of BAS could moderate the relationship
between neural changes and cortisol reactivity and recovery. In all,
this study suggested the important role of functional connectivity
between CEN and DAN in the process of stress resilience, and the
promotive effects of reward sensitivity measured by behavioral
activation system.
INCIDENTAL TUBERCULOMA IN A CHRONIC KIDNEY DISEASE PATIENT: A RARE EXTRA-PULMONARY MANIFESTATION OF TUBERCULOSIS
Authors: Sivanandam LOKESH KOUMAR , Jhoond Manpreet , Sujanyal Saurabh , Sridhar Shreya , Nasser Nathalie , Sanker Vivek , Gupta Umang
Published: January 2023

Chronic kidney disease associated with incidental tuberculoma represents
one of the rarest conditions occurring worldwide. Among tuberculous
patients, only 1% show Central Nervous System involvement. We present a
case of 45-year-old male with CKD who presented with seizure, diagnosed
to have incidental Tuberculoma
Whole genome sequencing reveals signals of adaptive admixture in Creole cattle
Authors: Jemaa Slim Ben , Adam Gabrièle , Boussaha Mekki , Klopp Christophe , Mandonnet Nathalie , Naves Michel
Published: January 2023

Admixture is an evolutionary process that enables short-term adaptation.
The Creole cattle from Guadeloupe is a tropically adapted breed. Its
three-way admixture and long-term isolation offer a unique opportunity
for understanding the genetic determinants of adaptive admixture in
livestock. Here, we sequenced 23 Creole cattle from Guadeloupe (GUA) and
combined our data with sequenced genomes of 99 cattle from 25 breeds
representative of European, African and indicine groups to provide the
most detailed exploration, to date, of patterns of genetic variation and
to detect selection signatures in this population. We detect 17 228 983
single nucleotide polymorphisms (SNPs) and we confirmed the higher level
of African and indicine ancestries, compared to the European ancestry,
in the GUA genome. We show that, unlike Criollo cattle, GUA population
originates directly from West Africa with indicine ancestry inherited
via West African ancestors. We relied on consistency of signals across
various methods based on excess of haplotype homozygosity, differences
in allele frequencies and excess ⁄ deficiency of local ancestry to
identify five strong candidate regions showing an excess of indicine
ancestry. These encompass immune-, heat-tolerance- and physical
exercise-related genes. Moreover, we found that a previously identified
horn-related gene, RXFP2 is under strong selective pressure in GUA
genome likely owing to human-driven (socio-cultural) pressure. Our study
highlights the role played by population admixture for driving rapid
adaptive response to local environmental constraints.
Assessment of dust emissions and their controlling factors in the Hoh Xil------north-central part of the Qinghai-Tibetan Plateau
Authors: Du Heqiang , Fan Yawei , Han Z , Liu Xiu , Xinlei Liu , zongxing li
Published: January 2023

Dust emissions can lead to a series of environmental hazards, such as
soil degradation, dust storms, and air pollution, and are thus a global
concern. As one of the most ecologically fragile and climate-sensitive
regions in the world, the Qinghai-Tibetan Plateau (QTP) has great dust
emission potential. However, the dust yield and its affecting factors
are not fully understood. To reduce these uncertainties on the QTP, the
Hoh Xil Plateau (HXP), a typical dust source on the QTP, was selected as
the study area to analyze the dust emission processes and the associated
influencing factors using a robust model. The results showed that dust
emissions on the HXP occurred mainly in spring and winter. The land use
on the HXP is the main reason for the high dust emissions, as the
grasslands and bare lands that are extensively distributed in this
region contain abundant erosive materials. The recession regions of the
expansive lakes resulted in an increase in sandy lakeshores, which
induced a potential increase in the dust emissions under strong-wind
conditions. In addition, the effects of human activities on dust
emissions were evident. The positive and negative effects on dust
emission changes coexisted on the HXP and depended on the development of
the county-level economy and the implementation of ecological
engineering measures. We believe this study will clarify the dust yield
of the QTP and provide valuable information for understanding the
driving factors that cause variations in aeolian processes on the QTP.
Crystalline silicon solar cells with thin poly-SiO x carrier-selective passivating contacts for perovskite/c-Si tandem applications
Authors: Singh Manvika , Datta Kunal , Amarnath Aswathy , Wagner Fabian , Zhao Yifeng , Yang Guangtao , Bracesco Andrea , Phung Nga , Zhang Dong , Zardetto Valerio , Najafi Mehrdad , Veenstra Sjoerd C. , Coletti Dr. Gianluca , Mazzarella Luana , creatore mariadriana , Wienk Martijn M. , Janssen Rene , Weber Arthur , Zeman Miro , Isabella Olindo
Published: January 2023

Single junction crystalline silicon (c-Si) solar cells are reaching
their practical efficiency limit while perovskite/c-Si tandem solar
cells have achieved efficiencies above the theoretical limit of single
junction c-Si solar cells. Next to low-thermal budget silicon
heterojunction architecture, high-thermal budget carrier-selective
passivating contacts (CSPCs) based on polycrystalline-SiO
(poly-SiO ) also constitute a
promising architecture for high efficiency perovskite/c-Si tandem solar
cells. In this work, we present the development of c-Si bottom cells
based on high-temperature poly-SiO CSPCs and
demonstrate novel high-efficiency four-terminal (4T) and two-terminal
(2T) perovskite/c-Si tandem solar cells. First, we tuned the ultra-thin,
thermally grown SiO . Then we optimized the passivation
properties of p-type and n-type doped poly-SiO CSPCs.
Here, we have optimized the p-type doped poly-SiO CSPC
on textured interfaces via a two-step annealing process. Finally, we
integrated such bottom solar cells in both 4T and 2T tandems, achieving
28.1% and 23.2% conversion efficiency, respectively.
Distribution characteristics of temperature and species in micro-structured heat-exchanger reactors
Authors: Chen Junjie
Published: January 2023

Microchannel reactor designs suffer from a fundamental limitation
resulting from the flow configuration in which a reacting stream flows
parallel to a heat transfer surface through which the majority of heat
is transferred perpendicular to the direction of fluid flow. The present
study aims to provide a unique microchannel fluid processing system for
performing chemical reactions with temperature control. The present
study relates to a unique method for performing reversible endothermic,
exothermic reactions, and competing reactions. The method comprises
flowing reactants through a reaction channel in thermal contact with a
heat exchange channel, and conducting heat in support of the reaction
between the reactants and fluid flowing through the heat exchange
channel to substantially raise or lower the temperature of the reactants
as they travel through the reaction channel.  Particular emphasis is
placed upon how to provide improved conversion and selectivity in
chemical reactions, provide chemical reactor systems that are compact,
and provide thermally efficient chemical reactor systems. The
distribution characteristics of temperature and species in
micro-structured heat-exchanger reactors are investigated and the
reactor performance is evaluated by performing numerical simulations
using computational fluid dynamics. The results indicate that
microchannel technology is capable of high heat and mass transfer
coefficients between a bulk reaction fluid and the catalytic heat
exchange surface. Carbon monoxide output from the fuel processor is
controlled over the operating range of the processor. When the reaction
in the reaction chamber is a reversible exothermic reaction, heat is
generated in the reaction chamber and transferred to the heat exchange
fluid. Microchannel reactors offer less resistance to heat and mass
transfer thus creating the opportunity for dramatic reductions in
process hardware volume. While a steam reforming catalyst in the form of
a powder or pellets is appropriate in larger devices, diminished
performance may result in the form of a powder or pellets in miniature
devices and reactors. The steam reforming catalyst contains a suitable
amount of at least one metal oxide and cerium to contribute to high
methanol conversion properties. The shift reaction increases hydrogen
yield while reducing carbon monoxide. Microchannel reactors offer the
advantage of exceptional heat exchange integration and can be utilized
for approaching optimum temperature trajectories for exothermic,
reversible reactions.

Keywords: Distribution characteristics; Chemical kinetics;
Temperature trajectories; Fluid streams; Thermal gradients; Reaction
selectivity
Behavior of amagmatic orogenic geothermal systems: insights from the Agua Blanca Fault, Baja California, Mexico
Authors: Martínez Daniel Carbajal , Wanner Christoph , Diamond Larryn W. , Peiffer Loic , Fletcher John M. , Inguaggiato Claudio , Lopéz Manuel Contreras
Published: January 2023

Amagmatic geothermal systems within regional-scale orogenic faults are
promising renewable resources for heat and possibly electricity
production. However, their behavior needs to be better understood to
improve exploration and assessment of their energy potential. To provide
more insight, we report a geochemical, geological, and geophysical study
of seven hot spring sites strung along a 90 km segment of the Agua
Blanca Fault (ABF), which traverses a mountainous region of northern
Baja California, Mexico. Our results show that topographic heads drive
infiltration of meteoric water deep into basement rocks, where it is
heated according to the local geothermal gradient (15–24 °C/km). Our
diverse dataset provides strong evidence that the flow system,
magnitude, and location of the thermal anomalies are primarily
controlled by the permeability of the ABF system and the hydraulic head
gradients. The hot water ascends along preferentially permeable zones,
discharging at temperatures from 37 °C in inland springs to 102 °C at
the Pacific coast. Higher temperatures correlate positively with the
degree of extensional fault displacement (a proxy for fault
permeability). Correlations between hydraulic head gradients, residence
times, and 3He/Hetotal of the thermal waters show that the hydraulic
head gradient controls the length and depth of the flow paths. Long
paths to great depths lead to long water residence times and high
3He/Hetotal fractions. Optimal conditions at the coast allow the 120 °C
temperature threshold for electricity production to be reached at
relatively shallow depths (< 4 km), demonstrating the
potential of orogenic geothermal systems for petrothermal exploitation.
APPLICATION OF MICRONUTRIENTS AS P-FERTILIZER COATINGS FOR PRECISION DISTRIBUTION IMPROVES NUTRIENTS USE EFFICIENCY IN SOYBEAN CROP ENVIRONMENT
Authors: Nunes Ana Paula , Takayama Thalita , Sarkis Leonardo , Guelfi Douglas
Published: January 2023

Problems related to the uniform distribution of micronutrients and their
low use efficiency are common. One possible solution is to add
micronutrients as fertilizer coating. However, it is necessary to
comprehend the use of micronutrients applied via coating and their
nutrition in the phenological stages of soybean. Therefore, the
objectives of this study were to quantify the diffusion and the
availability of P, B, Cu, Mn, and Zn in soil after the incubation of
fertilizers coated with micronutrients, as well as to evaluate the
nutrition, yield, and recovery of nutrients at different soybean
phenological stages under controlled and field conditions. The
treatments were MAP and NPS coated with Maxxi-Phós® polymer and one of
the micronutrient sources: Wolftrax®, Microsol®, or MIB Precise®. The
P-diffusion ranged from 5.58 to 18.88 mm. The nutrient recovery varied
according to the phenological stage of the plants with emphasis on the
V4 stage, which resulted in the following recoveries: B (13.89 to
0.65%), Cu (62.84 to 6.73%), Mn (3.36 to 0.73%), Zn (2.34 to 0.01%).
Nutrient exports by soybean were: 55.7 kg ha-1, 209.6, 109, 216.7, and
64.3 g ha-1 of P2O5, B, Mn, Zn, and Cu, respectively. Under field
conditions, there was a significant absorption of B, Mn, and Zn at
stages R1 to R5.1, while for Cu it was between V4 and R1. The NPS + MIB
Precise® fertilizer showed lower accumulations and yield, indicating
lower solubility of micronutrients supplied via oxysulfate. The
technologies were able to replace the exported nutrients by the soybean.
Drone imagery forest fire detection and classification using modified deep learning model
Authors: Mashraqi Aisha , Asiri Yousef , Algarni Abeer , Abu-Zinadah Hanaa
Published: January 2023

With the progression of information technologies, unmanned aerial vehicles
(UAV) or drones are more significant in remote monitoring the environment.
One main application of UAV technology relevant to nature monitoring is
monitoring wild animals. Among several natural disasters, Wildfires are one
of the deadliest and cause damage to millions of hectares of forest lands or
resources which threatens the lives of animals and people. Drones present
novel features and convenience which include rapid deployment, adjustable
and wider viewpoints, less human intervention, and high maneuverability.
With the effective enforcement of deep learning in many applications, it is
used in the domain of forest fire recognition for enhancing the accuracy of
forest fire detection through extraction of deep semantic features from
images. This article concentrates on the design of the drone imagery forest
fire detection and classification using modified deep learning (DIFFDC-MDL)
model. The presented DIFFDC-MDL model aims in the detection and
classification of forest fire in drone imagery. To accomplish this, the
presented DIFFDC-MDL model designs a modified MobileNet-v2 model to generate
feature vectors. For forest fire classification, a simple recurrent unit
model is applied in this study. In order to further improve the
classification outcomes, shuffled frog leap algorithm is used. The
simulation outcome analysis of the DIFFDC-MDL system was tested utilizing a
database comprising fire and non-fire samples. The extensive comparison
study referred that the improvements of the DIFFDC-MDL system over other
recent algorithms.
Retrospective analysis of hospitalization rates in patients with schizophrenia 12 months before and 12 months after the switch on once-monthly long-acting injectable paliperidone palmitate
Authors: Totic-Poznanovic Sanja , Markovic Milos
Published: January 2023

Background/Aim. There is no available published data about the use of long-acting injectable paliperidone palmitate (PP) in schizophrenia patients in the Republic of Serbia. The aim of this study was to assess hospitalization rates be-fore and after the switch to once-monthly long-acting injectable PP in schizophrenia patients, as well as their compliance with this drug. Methods. We conducted a retrospective cross-sectional study in which hospitalization rates were evaluated 12 months before and 12 months after the switch to once-monthly long-acting injectable PP in 113 schizophrenia patients. The age of the enrolled patients was between 18 and 66 years. Results. The average age of the enrolled patients was 38.36 ? 11.62 years. Among them, 77 (68.1%) were male, and 36 (31.9%) were female. Out of the total number of 113 patients treated with once-monthly injectable PP, 78 (69.03%) were on monotherapy, while 35 (30.97%) had one additional oral antipsychotic (risperidone, olanzapine, aripiprazole, or clozapine). Out of the total number of 113 patients, 68 (60.18%) were not hospitalized in the 12-month period before the switch to once-monthly long-acting injectable PP, while 45 (39.82%) were hospitalized in the same period. Given that 8 patients out of the total number of 113 were excluded from therapy due to an adverse event or their own decision in the period after the switch to PP, the analysis of the hospitalization rate after the switch to PP was performed for the remaining 105 patients, of which 9 (8.57%) were hospitalized in the period after the switch to PP, and 96 (91.43%) were not. Conclusion. Our results show high compliance in the treatment with once-monthly injectable PP and a positive impact of treatment with this drug on low hospitalization rate in a 12-month period in patients with schizophrenia. Considering the availability of this drug in the Republic of Serbia, these results encourage the use of once-monthly injectable PP as an important therapeutic option in schizophrenia patients.
Practical analysis of the impact of social marketing strategies on attitudes of potential reproductive cell donors in the Republic of Serbia
Authors: Djordjevic Biljana , Mitrovic-Jovanovic Ana , Janicic Radmila
Published: January 2023

Background/Aim. There is a constant increase in the need to use third-party reproductive cells among couples who are unable to conceive with their own reproductive cells or in order to prevent the passing of an existing hereditary genetic disorder to the child. The aim of the study was to present a theoretical overview and perform a practical analysis of the use of social marketing strategies using the first technique of analyzing the attitudes of potential donors of reproductive cells in the Republic of Serbia (RS) in the interest of adapting to the target group. Methods. Empirical research in this study, in which both women and men from the RS participated, was based on a questionnaire about people?s willingness to be potential reproductive cell donors and about having information on the donation of reproductive cells. The data in this paper were obtained during 2021, and the questionnaire was focused on a particular population group. The questionnaire was sent to people aged 20 to 34 years who could become potential donors of reproductive cells. In the research, 201 women and men from the RS participated. The first part of the questionnaire was tested for internal consistency, which was tested by Cronbach?s alpha coefficient calculation (?). Values of ? lower than 0.5 indicate that the questionnaire possesses unacceptable conistency. Results. A total of 57% of participants were in-formed about reproductive cell donation through the Internet, 29% by friends and family, and 11% of them were informed by doctors. Only 32% of participants were fully informed, and 25.1% were partially informed about the donation of reproductive material in the RS. Forty-three percent of participants were not informed about the donation of re-productive material. Most of the participants (54%) said they would maybe donate their reproductive material if they had more information, 20% would donate in any case, and 26% would refuse to donate reproductive material. Conclusion. The target group of potential donors of reproductive cells is present in the RS. In addition to the analysis of attitudes, further planning and implementation measures for the promotion of donation could have an influence on raising awareness about the lack of reproductive material and increase the recruitment of gamete donors.
Association between obesity and chronic kidney disease: multivariable Mendelian randomization analysis and observational data from a bariatric surgery cohort
Authors: Nguyen Anthony , Khafagy Rana , Gao Yiding , Meerasa Ameena , Roshandel Delnaz , Anvari Mehran , Lin Boxi , Cherney David Z.I. , Farkouh Michael E. , Shah Baiju R. , Paterson Andrew D. , Dash Satya
Published: January 2023

  

Obesity is postulated to independently increase chronic kidney disease (CKD), even after adjusting for type 2 diabetes (T2D) and hypertension. Dysglycemia below T2D thresholds, frequently seen with obesity, also increases CKD risk. Whether obesity increases CKD independent of dysglycemia and hypertension is unknown and likely influences the optimal weight loss (WL) needed to reduce CKD. T2D remission rates plateaus with 20-25%WL post-bariatric surgery (BS) but further WL increases normoglycemia/normotension. 

We undertook bidirectional inverse variance weighted Mendelian randomization (IVMR) to investigate potential independent causal associations between increased BMI and CKDeGFR (estimated glomerular filtration rate, eGFR < 60 ml/min1.73m2) and microalbuminuria (MA). In 5337 BS patients, we assessed whether WL influences >50% decline in eGFR (primary outcome) or CKD hospitalization (secondary outcome) using <20% WL as a comparator.

IVWMR suggests increased BMI increases CKDeGFR (beta=0.13, p=1.64x10-4), Odds ratio, OR (95% confidence interval, CI)=1.14(1.07-1.23) and MA (b=0.25, p=2.14 x 10-4,OR(95%CI)=1.29(1.13-1.48). After adjusting for hypertension and fasting glucose, increased BMI did not significantly increase CKDeGFR (b=-0.02, p=0.72), OR(95%CI)=0.98(0.87-1.1) or MA (b=0.19, p=0.08, OR (95%CI)=1.21 (0.98, 1.51).

Post-BS WL significantly reduced the primary outcome with 30-<40%WL (Hazard ratio HR=0.53, 95%CI=0.32-0.87), but not 20-<30%WL (HR=0.72, 95%CI=0.44-1.2) and ≥40%WL (HR=0.73, 95%CI=0.41-1.30). For CKD hospitalization, progressive reduction was seen with increased WL which was significant for 30-<40%WL (HR=0.37, 95%CI=0.17-0.82) and ≥40%WL (HR=0.24, 95%CI=0.07-0.89), but not 20-30%WL (HR=0.60, 95%CI=0.29-1.23).

The data suggests obesity is likely not an independent cause of CKD. WL thresholds previously associated with normotension and normoglycemia, likely causal mediators, may reduce CKD post-BS.
Comparison of the Color Change of Porcelain Laminate Veneers Produced by Different Materials After Luting with Three Resin Cements
Authors: Karaokutan I , Aykent F , Özdoğan MS
Published: January 2023

Objectives

This study aimed to compare color change of porcelain laminate veneers fabricated with two lithium disilicate ceramics and a zirconia-reinforced lithium silicate ceramic material after luting with conventional dual-cure, amine-free dual-cure, or light-cure resin cements using artificial accelerated aging (AAA).

Methods and Materials

Ninety noncarious human maxillary central incisors were embedded in autopolymerizing acrylic resin blocks to prepare conventional laminate veneers with incisal coverage. Prepared teeth were randomly divided into 3 groups (n=30) to fabricate laminate veneer restorations using: (1) lithium disilicate ceramic, (2) lithium disilicate ceramic with high-density micronization, and (3) zirconia-reinforced lithium silicate ceramic. Impressions of the preparations were taken with a laboratory scanner. Acquired 3D images were processed into a surface tessellation language file. Data were exported for 3D printing on a printer, and laminate veneers were printed in castable wax resin. Ceramic veneers were heat-pressed after investment according to the manufacturer’s recommendations and further divided into three groups (n=10) according to luting cement type: (1) light-cure resin cement, (2) amine-free dual-cure resin cement, and (3) conventional dual-cure resin cement. Color measurements were performed from the middle of each specimen with a spectrophotometer before and after AAA for 300 hours with a total energy of 150 kJ/m2. Color changes were calculated with the CIEDE 2000 (ΔE00) formula. Color differences were assessed using two-way analysis of variance (ANOVA) (α=0.05), and the paired t-test was used to compare the L*, a*, and b* parameters in each group before and after aging.

Results

There were no significant differences between the ceramic groups (p>0.05). The color changes of the materials ranged from 2.26 to 3.13. All materials were above the clinically acceptable limit (ΔE00>1.8). The conventional dual-cure resin cement group showed more color change (p>0.05).

Conclusions

Color changes were observed in all porcelain laminate veneers after artificial accelerated aging. The zirconia-reinforced lithium silicate veneers showed similar color changes as lithium disilicate veneers; the amine-free dual-cure resin cement showed a similar color change as light-cure resin cement after aging.
Museu dos Direitos Humanos do Mercosul: Perspectivas e fronteiras no processo de criação de uma instituição cultural mercosulina
Authors: Nogueira Carolina Gomes
Published: January 2023

O presente artigo traz como elemento fundamental a discussão sobre a criação do Museu dos Direitos Humanos do Mercosul como um elemento unificador para a construção da memória da violação dos direitos humanos no Cone Sul e para promoção do patrimônio cultural da região platina. Nesse sentido, o texto propõe uma reflexão sobre o que é um museu do Mercosul, e quais são as abordagens utilizadas por este aparelho cultural na construção de uma expografia voltada para os direitos humanos e que teve como missão divulgar a arte latino-americana. Este trabalho é parte resultante uma pesquisa de mestrado que está sendo desenvolvida no Programa de Pós-graduação em Memória Social e Patrimônio Cultural.
Luta Antimanicomial, interseccionalidade e feminismos
Authors: Reis Marilia Martins de Araújo
Published: January 2023

Trata-se da Resenha Crítica do livro Luta Antimanicomial e Feminismos: dimensões de gênero, raça e classe para a Reforma Psiquiátrica brasileira (PEREIRA; PASSOS, 2017), que aborda de modo interseccional, a temática da Luta Antimanicomial e Feminismos, relacionando-os com os marcadores de gênero, raça e classe, com sensibilidade e cientificidade pelas autoras, que se expressam no sentido de romper com as imposições do patriarcado, do sexismo, do racismo e da lgbtfobia. Na Resenha, dialoga-se com diferentes autores e com a musicalidade feminista contemporânea no Brasil, afirmativa da autonomia das mulheres, apontando para reflexões que levam à conclusão de que, enquanto houver capitalismo, haverá sexismo e racismo. Ressalta-se também a importância das militâncias feminista, dos direitos humanos e da Luta Antimanicomial, como fortes aliadas nas resistências diante da dominação, violações e retrocessos à Democracia.
Por que ocupamos? Uma introdução à luta dos sem-teto
Authors: Souza Maciana de Freitas e , Silva Aylana Paula dos Santos
Published: January 2023

Esta resenha tem como objetivo apresentar as contribuições do livro “Por que ocupamos? Uma introdução à luta dos sem-teto” de Guilherme Boulos. Para isso, apresenta-se o histórico do processo de desenvolvimento do movimento social no pais, seguido de dados para problematizar as lutas sociais efetivadas na atual conjuntura brasileira.
A Dimensão Política da Educação Ambiental no Projeto Político Pedagógico (PPP) de um Colégio Estadual em um município no sudoeste do Paraná
Authors: Cordeiro Thainá Marcella , Amaral Anelize Queiroz , De Lima Daniela Macedo , Boeno Rosangela Maria
Published: January 2023

O presente estudo, traz como objeto de pesquisa, a análise do Projeto Político Pedagógico (PPP), de um determinado Colégio Estadual, localizado em um município do Sudoeste do estado do Paraná - Brasil. Desta forma, traz-se como problema de pesquisa a investigação acerca de possíveis indicadores que apontem para a dimensão política da Educação Ambiental presente no PPP. Sendo assim, este trabalho traz um breve panorama histórico sobre a Educação Ambiental desde seu surgimento até ser discutida no âmbito da Educação brasileira e a incorporação desta em documentos oficiais. Para tanto, o percurso metodológico utilizado nessa pesquisa, foi de cunho qualitativo por meio do levantamento bibliográfico e da análise documental do PPP do Colégio Estadual em questão, portanto, buscou-se verificar como a Educação Ambiental vem sendo desenvolvida no colégio, e se neste documento PPP evidencia-se indicadores da dimensão política da Educação Ambiental e de que forma são mencionados. Contudo, após as análises observou-se a presença da Natureza Política da Educação Ambiental, bem como os limites e possibilidades do desenvolvimento dessa prática na Instituição de Ensino de Educação Básica. Ainda, foi possível visualizar a busca pelo desenvolvimento do senso crítico de seus educandos e a construção da formação de sujeitos reflexivos quanto ao atual modelo de relação sociedade-natureza.
A fábula e o processo de mudança, cultura e liderança
Authors: OLiveira Lucas Pereira de
Published: January 2023

Esta resenha tem objetivo dimensionalizar os escritos de John Kotter, cuja narrativa apresenta a fábula do pinguim, contendo questões como: o processo de mudança, cultura e liderança dentro do processo social. Com o processo de definir e teorizar um cenário, arquitetar os passos e decisões, a fim de se chegar ao fato, o autor cria uma dimensão cultural, desprendendo de tradições que já não suprem as necessidades imediatas.
O Boletim de Ariel e sua abrangência no cenário literário e cultural brasileiro na década de 1930
Authors: Marzani Andressa
Published: January 2023

Este artigo se propõe a refletir sobre a importância da publicação Boletim de Ariel, da Editora Ariel, sediada no Rio de Janeiro para o cenário cultural brasileiro. A revista era publicada mensalmente e trazia textos sobre literatura, artes e cultura em geral, apresentando lançamentos de livros, crítica literária, e até mesmo debates sobre política e religião. Conseguiu atrair escritores de diferentes estilos e vertentes, caracterizando-se como uma publicação heterogênea, que contou com a colaboração de diferentes autores, com opiniões e visões de mundo diversas. Nesse sentido, tentou-se demonstrar como a revista esteve inserida em importantes debates do período, que ultrapassavam as barreiras culturais, refletindo sobre a importância dos periódicos, a produção cultural modernista como um todo e sua relação com as discussões políticas e sociais da época.

Palavras-chave: Boletim de Ariel; Editora Ariel; Literatura brasileira do século XX; Modernismo no Rio de Janeiro; Revistas literárias.
Ensino de ciências da natureza e diversidade: epistemologias emergentes em periódicos latino-americanos
Authors: Rodrigues Marta  de Souza , Leite Cristina
Published: January 2023

Este artigo aborda a inserção do ensino de ciências da natureza em discussões transversais contemporâneas a partir da realização de um estado da arte em periódicos latino-americanos, envolvendo o tema da diversidade cultural no contexto da produção de conhecimentos. Os estudos decoloniais e as noções de epistemologias emergentes e epistemologias do Sul foram utilizados como aportes teóricos na investigação. O estudo sobre as publicações utilizou como referencial a análise de conteúdo e entre os resultados principais do levantamento, destacamos: o pequeno número de publicações relacionadas mais diretamente às ciências da natureza; a potencialidade da astronomia para tratar da construção do conhecimento em uma perspectiva plural no campo das ciências naturais; a maior recorrência de trabalhos voltados à matemática, tendo em vista o desenvolvimento de áreas como a etnomatemática; a utilização de perspectivas decoloniais como referencial teórico em discussões sobre outras epistemologias na América Latina.
Patrimônio cultural
Authors: Weber Dorcas , Pessoa Elanne de Freitas
Published: January 2023

Este artigo propõe trazer à discussão a temática do patrimônio cultural e suas abordagens nos livros didáticos de Artes Visuais. A Base Nacional Comum Curricular sugere sua inserção no contexto da educação básica, contudo, inquieta saber se os livros didáticos disponibilizados pelo Programa Nacional do Livro e do Material Didático, para as escolas públicas brasileiras apresentam esta temática em seus conteúdos. Desta forma, foi realizada uma observação em livros didáticos de Arte, elaborados para os anos finais do Ensino Fundamental, disponibilizados pelo Programa Nacional do Livro e do Material Didático para o ano de 2020. Buscou-se verificar de que modo a temática está presente em tais produções bibliográficas. Por meio desta observação, concluiu-se que a temática ainda é tema incipiente, visto que não está presente em todas as publicações. Além disso, naquelas onde aparece é abordada de modo superficial e restrito a circuitos e produções legitimadas. Com isso, percebe-se a importância na ação docente em expandir as proposições apresentadas pelos livros didáticos, a partir de outros recursos complementares.
Práticas pedagógicas na Educação Física sob uma abordagem multidisciplinar no caminho descolonial
Authors: Bresolin Marcio Rogerio , Ortiz Marcela dos Santos , Bessa-Oliveira Marcos Antônio
Published: January 2023

Este artigo apresenta uma proposta desenvolvida por meio da disciplina de Educação Física, intitulado “Práticas pedagógicas na Educação Física sob uma abordagem multidisciplinar no caminho descolonial”, na Educação Básica em Maracaju, com a finalidade de atender as determinações da LDB 9.394/96 conforme artigo 26. As referências utilizadas são MOREIRA; CANDAU (2013), HALL (2016), BESSA-OLIVEIRA (2019), MIGNOLO (2014), os PCNs da disciplina de Educação Física, entre outros. O objetivo é apresentar a Educação Física escolar como componente curricular com saberes multidisciplinares por meio de práticas diferenciadas na escola. A metodologia da pesquisa é bibliográfica e pesquisa-ação e ocorre com a execução de atividades na em uma escola Estadual no município de Maracaju–MS. Os itinerários práticos aqui apresentados foram desenvolvidos utilizando conteúdos e eixos preestabelecidos pelo Governo Estadual para o projeto AJA em construir situações de movimentos, enfatizando também aspectos pedagógicos, sociais e culturais diversos dos saberes. Os resultados apontam que realmente é possível ter práticas multidisciplinares e descoloniais em Educação Física, com possibilidades de aprender os saberes através dos saberes de outras disciplinas e como uma epistemologia outra.
O movimento sociocultural judaico de Santa Maria no Rio Grande do Sul
Authors: Kopstein Marcos Antunes
Published: January 2023

A cidade de Santa Maria historicamente foi marcada pela influência de uma comunidade judaica forte e rica culturalmente. Propõe-se neste trabalho, discorrer a respeito de situações que ensejaram o florescimento da comunidade no seio de Santa Maria, situada na região central do estado do Rio Grande do Sul. Num primeiro plano, enfoca-se na vinda de judeus para o assentamento agrícola chamado de Colônia Philippson, para depois relatar a migração para a zona urbana e o desenvolvimento do comércio judeu em Santa Maria. Ainda, explanase o resultado paisagístico judeu na cidade, ao se analisar questões concernentes à Sinagoga Yitzhak Rabin. Objetiva-se ainda estipular que essa comunidade é representada pela Sociedade Beneficente Israelita de Santa Maria, caracterizando-se assim a comunidade judaica na região, não somente pelo viés religioso, mas também por se enquadrar como um movimento sociocultural.
Análise Documental das Ações Inclusivas do IFMS Sobre Estudantes com Necessidades Educacionais Específicas
Authors: Augusto Tayomara Hanako de Almeida Higa , Augusto Tiago Rodrigues de Lemos , Nascimento Valdir Aragão do , Grillo Jocimara Paiva
Published: January 2023

No Brasil, a preocupação com a instrução das pessoas com necessidades educacionais específicas data do Império. Atualmente é consenso que não basta estes estudantes estarem matriculados na escola, eles têm que receber um suporte pedagógico que os auxilie nas suas dificuldades específicas educacionais. Partindo dos embasamentos legais e de teóricos como Capellini (2004), Mantoan (2013) e Perrenoud (2005), visando a perspectiva da inclusão escolar quanto às ações inclusivas nos documentos do Instituto Federal de Educação, Ciência e Tecnologia de Mato Grosso do Sul (IFMS), sobre estudantes com necessidades educacionais específicas, esta pesquisa teve como objetivo investigar a política aplicada pelo IFMS e as políticas públicas nacionais da educação especial e inclusiva, buscando entender a dinâmica do processo para propor soluções a possíveis entraves encontrados. No tocante à metodologia, utilizou-se a revisão bibliográfica e documental, operacionalizada pela coleta e análise de dados disponibilizados no site do Instituto Federal de Educação, Ciência e Tecnologia de Mato Grosso do Sul (IFMS). A partir da análise dos dados estabelecemos um paralelo com as leis vigentes no Brasil para averiguar se as ações institucionais corroboram com nacionais. Contudo, o presente estudo deixa claro que as políticas aplicadas pela Instituição corroboram com as nacionais, mas de forma parcial, descontínua e insuficiente. Essa conclusão deve-se ao fato de que as ações institucionais apresentam algumas lacunas; que devem ser preenchidas para viabilizar uma melhor aplicação das ações inclusivas ao estudante com NEE.
Análise preliminar do perfil do público frequentador do Teatro Rotary em Passos/MG
Authors: Augustinho Débora , Vieira Isabella Cristina Ribeiro , Santos Andressa Graciele dos , Meireles Eduardo
Published: January 2023

O presente artigo tem como objetivo investigar a função social do equipamento cultural conhecido como Teatro Rotary, localizado no município de Passos - MG, e ainda identificar, de maneira preliminar, possíveis fragilidades no desenvolvimento de políticas públicas destinadas ao setor de cultura. Para determinada finalidade foi elaborado um questionário na plataforma Google Forms de maneira a traçar um perfil do público frequentador, caracterizando informações das pessoas no tangente aos aspectos de moradia, renda familiar, estado civil, moradia e sexo. Os dados respondidos por 174 pessoas foram organizados em planilhas tabulares para facilitação de análises e propiciou a criação de mapa temático em software livre Quantum GIS (QGIS), identificando o bairro de residência dos frequentadores que vão aos eventos e espetáculos no Teatro. Os resultados encontrados mostraram que a maior parte do público frequentador advém de bairros de classe média e classe alta, os quais possuem renda familiar de 3 a 6 salários-mínimos, em sua maioria sendo do sexo feminino e autodeclarados como de cor branca. Essa elitização demonstra, mesmo que de forma embrionária, uma desigualdade no consumo cultural por parte da sociedade passense quanto à carência de espaço físico que abrigue eventos culturais.