bluuebunny/crossref_metadata_2025 huggingface dataset:
Peran Pendidikan Kebinekaan dalam Pendidikan Kewarganegaraan untuk Menciptakan Lingkungan Sekolah yang Damai
Authors: Istianah Anif , Darmawan Cecep , Sundawa Dadang , Fitriasari Susan
Published: July 2024

Pendidikan kebinekaan dalam pembelajaran Pendidikan Kewarganegaraan bertujuan menciptakan sekolah yang damai dengan mengintegrasikan kebijaksanaan lokal dan materi PKn. Fokus utamanya adalah membangun perdamaian di lingkungan sekolah. Nilai-nilai kebinekaan dapat dimasukkan ke dalam kurikulum Pendidikan Kewarganegaraan untuk mencapai tujuan pendidikan kedamaian. Penelitian ini menggunakan metode kualitatif dengan sumber yang berhubungan dengan pendidikan multikultural untuk perdamaian. Teknik pengumpulan data meliputi wawancara, studi dokumentasi, dan observasi. Hasil penelitian menunjukkan bahwa menggabungkan pendidikan kebinekaan dapat meningkatkan pemahaman siswa terhadap nilai-nilai kearifan lokal serta memperkuat toleransi dan penghargaan terhadap keberagaman. Pendidikan Kewarganegaraan berperan positif dalam menciptakan lingkungan sekolah yang damai dengan mempromosikan pemahaman lintas budaya dan mempersiapkan siswa untuk aktif dalam pembangunan masyarakat yang beradab. Pendidikan perdamaian adalah salah satu pendekatan pengembangan karakter yang bertujuan menumbuhkan budaya damai melalui tiga hal: (1) mengurangi kekerasan, (2) mendorong respons damai terhadap konflik, seperti berdialog, menghindari konfrontasi, dan menunjukkan toleransi, serta (3) mengajarkan pengendalian diri dan menahan diri. Lingkungan yang ideal bagi manusia adalah kedamaian. Inisiatif untuk memerangi bullying di sekolah dapat membangun program anti-bullying berdasarkan nilai-nilai kearifan lokal, menciptakan kenyamanan bagi peserta didik untuk mewujudkan sekolah yang damai.
Persepsi tentang Kebinekaan Global Warga Negara: Penelitian pada Mahasiswa di Universitas Ahmad Dahlan
Authors: Siti Aulia Syifa , Marzuki  , Suyato
Published: July 2024

Dalam era globalisasi, kebinekaan menjadi isu yang mendesak di berbagai belahan dunia. Kebinekaan, mencakup keragaman etnis, budaya, agama, dan bahasa, memperkaya kehidupan sosial namun juga menimbulkan tantangan dalam menciptakan harmoni sosial. Pendidikan tinggi memainkan peran penting dalam membentuk pandangan dan sikap mahasiswa terhadap kebinekaan global. Di Indonesia, negara dengan kekayaan budaya yang kaya, kebinekaan global menjadi aspek yang unik, menyoroti tantangan masyarakat multikultural. Studi ini fokus pada persepsi mahasiswa Universitas Ahmad Dahlan terhadap kebinekaan global, mengidentifikasi faktor-faktor yang memengaruhi pandangan mereka. Metode survei digunakan untuk mengumpulkan data, dengan hasil menunjukkan bahwa mahasiswa mengakui pentingnya keberagaman global dan melihatnya dalam konteks kewarganegaraan. Mereka melihat penghormatan budaya dan musyawarah sebagai solusi untuk tantangan kebinekaan. Pengajaran yang tanggap budaya diperlukan dalam menanggapi keragaman etnis dan budaya di tingkat pendidikan tinggi, yang dapat meningkatkan prestasi siswa dan memperkuat keterhubungan global. Namun, tantangan dalam mengimplementasikan pendidikan kewarganegaraan global di Indonesia termasuk kurangnya keahlian guru, keterbatasan waktu dan anggaran, serta kurikulum yang padat. Penelitian ini memberikan wawasan tentang persepsi mahasiswa terhadap kebinekaan global dan menyarankan strategi pendidikan yang lebih responsif terhadap kebutuhan masyarakat yang semakin beragam.
Supervisi Nilai Keseriusan Guru dalam Menilai Hasil Belajar di Sekolah Menengah Pertama
Authors: Gultom Norita , Elhawwa Tazkiyatunnafs , Zannah Fathul
Published: July 2024

Tujuan penelitian ini untuk mengukur supervisi nilai keseriusan untuk melihat kemampuan guru dalam menilai hasil belajar peserta didik. Subjek penelitian adalah guru wali kelas di Sekolah Menengah Pertama yang terdiri dari 8 orang guru. Objek penelitian adalah peningkatan kemampuan guru dalam melakukan kegiatan penilaian hasil belajar. Lokus penelitian berada di Sekolah Menengah Pertama Santa Maria Muara Teweh. Teknik pengumpulan data menggunakan observasi, wawancara dan dokumentasi. Analisis data dilakukan dengan membaca data dengan cara membandingkan hasil dari sebelum dilakukan tindakan dan sesudah tindakan. Analisis data ini dilakukan pada saat tahapan refleksi. Temuan penelitian yaitu pelaksanaan supervisi kelas terbukti dapat meningkatkan kemampuan guru dalam melaksanakan kegiatan penilaian hasil belajar. Guru menunjukkan nilai keseriusan dalam memahami dan melaksanakan kegiatan penilaian hasil belajar. Observasi memperlihatkan bahwa terjadi peningkatan kemampuan guru melaksanakan kegiatan penilaian hasil belajar dari siklus ke siklus. Pada siklus I nilai rata-rata capaian secara klasikal dari 42,82 dengan kategori kurang, meningkat menjadi 67,82 dengan kategori cukup serta pada siklus terakhir menjadi 86,11 dengan kategori baik, dan secara individual per guru dari 2 orang atau 33,33% pada siklus pertama meningkat menjadi 100% atau 6 orang guru pada siklus terakhir.
On the Question of the Beginning of Slavophilism: A.S. Khomyakov’s Article “About the Old and the New”
Authors: Popov Andrei ,   Lomonosov Moscow State University
Published: July 2024

The article deals with the question of the initial stage of the history of Slavophi­lism. Based on the contents of the letter by E.A. Khomyakova, found in 2000, it is concluded that the first handwritten article by A.S. Khomyakov “On the old and the New” was written in early 1837. This finding is the basis for the revision of ex­isting ideas that the Slavophile doctrine originated in the winter of 1839. Accord­ing to the author, this article by Khomyakov was a response to N.M. Karamzin’s note “On ancient and New Russia in its political and civil relations”. A compara­tive analysis of the main provisions of the content of these works is carried out. Karamzin’s views, according to the author, corresponded to conservative tradition­alism, which calls for the preservation of the existing order. Khomyakov’s ideo­logy corresponds to the archaic traditionalism that arises during periods of histori­cal development, when the attractive features of the social structure have been lost and one can only hope for their possible revival. The archaic proponent under­stands that it is no longer possible to revive the past in its entirety. His ideal is forced to adapt to the conditions of modern society. The article considers the reply message of I.V. Kireevsky “In response to Khomyakov”, which was written in the winter of 1839. The question of the general and special in the views of A.S. Khomyakov and I.V. Kireevsky is analyzed on the basis of the content of their first articles. According to the author of the article, criticism of the official ideology was one of the ideological sources of the formation of the Slavophile doctrine.
Fisher, D., Frey, N. (2021). Better learning through structured teaching: A framework for the gradual release of responsibility (3rd ed.)
Authors: Somaratne Ruwani Tharaka
Published: July 2024

Book review
Peranan Home Industry Rangginan Desa Kambeng Ponorogo Terhadap Perekonomian Keluarga
Authors: Firda Risca Nur , Nurma Fitrianna
Published: July 2024

Home industry is one of the supporters of community empowerment in rural areas, especially women, Mrs. Muji's home industry rangginan is one of them. The problem in this study is one of the problems in people's lives, especially related to improving the welfare of the community, so in this study it is discussed about the home industry that can improve the economy of the family community to achieve community welfare. The purpose of this study was to determine the role of the Rangginan home industry in increasing the income of the families of the surrounding community and to explain the impact of the Rangginan home industry on increasing the family income of the surrounding community. The research used is field research using a qualitative approach. from the results of the study indicate that the home industry in an effort to improve the economy of the family of Mrs. Muji and the community is able to bring positive changes to the economy of the surrounding community. From an Islamic perspective, the role of Ibu Muji's home industry in the economy of Muji's family and the surrounding community in general has all fulfilled the basic objectives and concepts of Islamic economics and in accordance with related theories, but in recruiting the rich they tend to recruit non-permanent employees in order to empower the surrounding communit.
Efektivitas Program Kartu Prakerja Dalam Meningkatkan Kesejahteraan Penerima Pada Kecamatan Sampung Ponorogo Ditinjau Perspektif Ekonomi Islam
Authors: Anik Nur Ria  , Candra Febrilyantri
Published: July 2024

Introduction: Effectiveness is a measure that shows the extent to which an objective in terms of quantity, quality and time has been achieved in management, as well as what goals have been achieved to create creativity. The existence of a pre-employment card program for job seekers, people who have lost their jobs, as well as for people who want to improve their skills to meet their daily needs is very important to improve people's welfare. The main objective of this study was to analyze the implementation of the pre-employment card program in Sampung District, and to analyze the strategy of the pre-employment card program in the selection process in Sampung District, to analyze the effectiveness of the pre- employment card program in improving people's welfare in Sampung District. Research Methods: This research method uses a qualitative approach and this type of research uses a type of field research. Collecting data using interviews, observation, and documentation. Techniques in data analysis using data collection, data reduction, data presentation, and drawing conclusions. Results: Based on the results of field research, the authors concluded: 1) The enthusiasm for the implementation of the pre-employment card program in Sampung District was very high, both for the local government and its residents. 2) The strategy adopted is to present an IT team in each village and disseminate this information on social media. 3) The welfare of the community itself has not been fully fulfilled, but from the incentives obtained for additional business capital for daily needs, so that related to the welfare of the Islamic perspective has been fulfilled due to an increase in the economic level, and related to skills welfare is also fulfilled where there is training.
Komunikasi Kepemimpinan Untuk Meningkatkan Kinerja Dalam Perspektif Ekonomi Islam (Study Kasus Pada UD Kaos Hasby)
Authors: Diah Ayu Rosanti  , Amin Wahyudi
Published: July 2024

Communication is an important element in a company. The source of information or communication sources mostly comes from leaders. A person's leadership has a great influence on the company. The aim of this research is to analyze the leadership practices carried out at UD Kaos Hasby from an Islamic economic perspective. This research uses a qualitative approach, namely research that is descriptive in nature and tends to use analysis. This research resulted in: 1) leadership communication practices carried out at UD Kaos Hasby. By focusing on the elements of communication, namely the message conveyed, the communicator, the communicant, the media used, and the consequences of the communication. 2) inhibiting factors and supporting factors for communication at UD Koas Hasby. The inhibiting factors are the lack of intensity of meetings between leaders and employees, as well as the lack of language skills possessed by some employees. Meanwhile, the supporting factors are leaders motivating employees and adequate facilities. 3) The impact of communication at UD Kaos Hasby is that it makes employee performance easier and problems can be resolved. From these several statements, the author concludes that the leadership communication that occurs at UD Kaos Hasby Mlarak is quite good and uses Islamic communication principles with Al-Qur'an themes, although there are several things that are obstacles and need to be improved.
Dampak Usaha Peternakan Ayam Terhadap Kehidupan Masyarakat di Kelurahan Mlilir Perspektif Etika Bisnis Islam
Authors: Kusumandari Nafia , Damanuri Aji
Published: July 2024

Chicken farming plays a role in improving the welfare of local communities in rural areas. Through a local economic development approach, chicken farming can create jobs, increase income, and contribute to regional economic growth. Business ethics is also related to norms in business activities, including establishing livestock pens. The distance between the settlement and the pen must be considered because it is related to air pollution and other environmental problems that can arise from livestock activities. This research aims to analyze the economic, environmental, and sociological impacts of poultry farming from the perspective of Islamic business ethics. The type of research used is field research using a qualitative descriptive approach. Data collection techniques used include observation, interviews, and documentation. The research results show that chicken farming has an economic impact by creating jobs and increasing people's income. However, there are negative impacts on the environment, such as air pollution, which shows an imbalance in applying business ethics principles. Apart from that, the low motivation of people to raise livestock shows a lack of social responsibility in ensuring social benefits for the surrounding community.
The Effect of Inflation, Exchange Rate, and Unemployment on Financing of the Islamic Commercial Bank Sector in Indonesia
Authors: Abdullah Abdullah
Published: July 2024

MSMEs are one of the main factors in encouraging national economic development, but the MSME sector in Islamic banking has fluctuated from year to year in Indonesia. This study aims to analyze the influence of the macro economy on financing the MSME sector in Islamic banking in Indonesia. This study uses time series data, namely monthly data on the financial statements of Islamic Commercial Banks and data on macroeconomic variables for 2018-2022 in Indonesia. The analysis method used in this research is Autoregressive Distributed Lag (ARDL). The results of this study indicate that this affects the financing of the MSME sector of Islamic Commercial Banks in the short-term inflation. In the long term, inflation affects the financing of the MSME sector of Islamic Commercial Banks. Other variables, namely exchange rates and unemployment, cannot affect the financing of the MSME sector of Islamic Commercial Banks.
Pengaruh ROA, DER, dan EPS Terhadap Return Saham Pada Perusahaan Makanan dan Minuman di ISSI 2019-2022
Authors: Halimatum Munawaroh  , Ruliq Suryaningsih
Published: July 2024

Introduction: The research in this thesis is motivated by the results of the financial reports of food and beverage sub-sector companies registered with ISSI for the 2019-2022 period. The selection of this sub-sector is based on the economic conditions of the research period, where this sub-sector is one of Indonesia's economic recoveries and can survive during the pandemic because it is one of society's primary needs. Returns in companies in this subsector experienced fluctuations due to policy changes during the pandemic and a mismatch between theory and the facts that occurred. Research Methods: This type of research is secondary research with a quantitative approach. Data collection uses documentation studies. This study's observations were 208, consisting of 13 sample companies. The sampling technique used is purposive sampling. The analytical method used is panel data regression analysis, which has previously undergone testing stages of the panel data estimation method, panel data regression model selection, classical assumption testing, and significance testing. Results: The results of this research show that the ROA variable has a significant positive effect on stock returns. The DER variable has no significant effect on stock returns. The EPS variable has a significant negative effect on stock returns. The variables ROA, DER, and EPS simultaneously significantly affect stock returns, with the coefficient of determination test results obtaining a value of 0.208. This value explains that the variables ROA, DER, and EPS affect stock returns of 20.8%.
Circuito Verde:
Authors: Goede de Souza Alexandra , Heuer Gabriel , Wasilkosky Gabrieli , Mateus Tamanini Elian , André Venturi Filipe , Charles Chorny Jonas , Schappo Lucas , Paula de Jesus Delfino Gabriela
Published: July 2024

O tema educação ambiental vem fazendo parte dos componentes curriculares tradicionais abordados nas escolas, tanto para atender a legislação brasileira como auxiliar na formação socioambiental da sociedade. Neste contexto, o objetivo do projeto foi proporcionar um espaço não formal de ensino para intervenção pedagógica com práticas integradoras envolvendo temas relacionados ao meio ambiente, formação cidadã e desenvolvimento socioambiental com estudantes da rede pública de educação da região do Alto Vale do Itajaí, SC, e proporcionar a pratica extensão aos envolvidos no projeto. O projeto foi desenvolvido no Instituto Federal Catarinense (IFC) - Campus Rio do Sul, envolvendo atividades integradas que incluem: relógio do corpo humano com plantas medicinais, sistema agroflorestal (SAF), abelhas sem ferrão (ASF), reciclagem de óleo de cozinha para produção de sabão, trilha ecológica e viveiro pedagógico no formato de circuito. Por tratar-se de projeto de diversas áreas, estavam envolvidos na sua execução integrantes do PET Agroecologia Rural Sustentável e estudantes do curso de Agronomia e técnico em Agropecuária integrado ao ensino médio. Cada circuito teve duração de três horas. Participaram do projeto cerca de 600 estudantes entre os anos de 2022 e 2023. Os grupos e as atividades foram acompanhados por profissionais e estudantes do IFC. A integração entre as práticas pedagógicas mostrou-se eficiente em despertar o interesse dos participantes por temas ambientais contribuindo na formação de uma consciência socioambiental. Permitiu a prática da extensão pelos estudantes e profissionais do IFC e maior interação com a comunidade, auxiliando na promoção da discussão de problemas ambientais atuais.
Pivotal roles of mitochondria in linking dopamine catabolism to axonal myelination: Implication for the pathogenesis and treatment of schizophrenia
Authors: Xu Haiyun , Yang Fan , Zhang Yi , Jiang Cuiting , Ouyang Na , Wang Qianqian , Wang Ping , Zheng Peiwen , Wang Wei , Zhang Handi , He Jue , Liu Yanlong , Lin Lingyun , Tong Zhiqian , Yu Xin
Published: July 2024

Schizophrenia is one of the most complex and debilitating brain diseases. Patients with schizophrenia may present various clinical manifestations that have been categorized into positive symptoms , negative symptoms, and cognitive deficits. In relation to these complex clinical manifestations, multiple hypotheses have been proposed to understand the pathogenesis of schizophrenia, such as the so-called dopamine (DA) hypothesis, mitochondrion hypothesis, oligodendrocyte (OL) hypothesis, etc. The concurrent existence of multiple hypotheses about one brain disease suggests a possible common neurobiological mechanism linking some of these hypotheses. This possible neurobiological mechanism has been demonstrated in this study with animal models of schizophrenia, cultured OLs, and neuron-OL co-cultures. Adolescent C57BL/6 mice given tolcapone (TOL) for two weeks showed DA elevation in prefrontal cortex (PFC), functional impairment of mitochondria in brain cells, and hypomyelination in PFC, hippocampus, and caudate putamen (CPu) in a dose-dependent manner, in addition to schizophrenia-related behaviors. The catechol-O-methyltransferase (COMT) gene knock-out (COMT-ko) mice presented dopaminergic dysfunctions in PFC and CPu, functional deficit of mitochondria, mature OL decrease, and hypomyelination in the same brain regions as those in TOL-treated mice. In cultured OLs, DA inhibited the cell development in a concentration-dependent manner while impairing mitochondrial functions. These effects of DA on cultured cells were ameliorated by the antioxidant N-acetyl-L-cysteine (NAC) and trans-2-phenylcyclopropy (TCP), an inhibitor of mitochondrial monoamine oxidases (MAOs). Moreover, DA inhibited axonal myelination in neuron-OL co-cultures while impairing mitochondrial functions. These data demonstrate the pivotal roles of mitochondria in linking DA catabolism to axonal myelination in the brain and provide a novel insight into the pathogenesis and therapeutic strategy for schizophrenia.
Environmental Implications of Physicochemical Differences Between Environmental Nanoplastics and Their Commercial Forms
Authors: Şengül HATİCE , Bülbül Onurcan , Şen Elif Hilal
Published: July 2024

Nanoplastics are ubiquitously present in the aqueous medium carrying an increased risk due to their size and extended lifetime. Behaviour of environmentally relevant nanoplastics in the aqueous medium differs from engineered nanoplastics because of alterations in physicochemical properties through natural aging. Examination of these alterations and their implications for environmental behaviour need to be studied urgently. This study aims to partially fill the gap by conceptual analysis of changes in environmental stability of five types of environmentally relevant nanoplastic models upon aging. Aged samples were taken from aged surfaces of plastics collected from nature that were altered naturally whereas young samples are from their original commercial counterparts. Five types of plastics were selected within the scope including the most widely used PVC (Polyvinyl chloride), PP (PolyPropylene), PS (Polystyrene) and Nylon66, and PET (PolyEthylene Terephthalate) plastics. Characterization techniques for identification of changes physicochemical properties at nanoscopic and molecular scales included Small-Angle X-ray Scattering (SAXS), Wide-Angle X-ray Scattering (WAXS) and Fourier-Transform Infrared Spectroscopy (FT-IR). The analysis revealed several notable differences between original and aged samples in terms of structural arrangement, size, shape, crystallinity, chemical structure, and surface functionalization. The effect of aging was the most pronounced for PP polymer. PVC polymer, on the other hand, stayed structurally the most similar to its original form whilst fragmentated to a signifant degree. Conceptual examination of implications for environmental stability revealed that aged nanoplastics could be less mobile in the aquatic medium than their original counterparts. Similar studies need to be vigoruously pursued to further address relevant physicochemical changes to formulate eco-design decisions for plastics production.
Rescue of lysosomal acid lipase deficiency in mice by rAAV8 liver gene transfer
Authors: Amendola Mario , Laurent Marine , Harb Rim , Jenny Christine , Oustelandt Julie , Jimenez Simon , Cosette Jeremie , Landini Francesca , Ferrante Aristide , Corre Guillaume , Vujic Nemanja , Piccoli Claudia , Brassier Anaïs , Wittenberghe Laetitia van , Ronzitti Giuseppe , Kratky Dagmar , Pacelli Consiglia
Published: July 2024

Lysosomal acid lipase deficiency (LAL-D) is an autosomal recessive disorder caused by mutations in the LIPA gene, which results in lipid accumulation leading to multi-organ failure. If left untreated, the severe form of LAL-D results in premature death within the first year of life due to failure to thrive and hepatic insufficiency. Enzyme replacement therapy is the only available supportive treatment consisting in weekly systemic injections of recombinant LAL protein. Here, we characterized a novel Lipa-/- mouse model and developed a curative gene therapy treatment based on the in vivo administration of recombinant (r)AAV8 vector encoding the human LIPA transgene under the control of a hepatocyte-specific promoter. We defined the minimal rAAV8 dose required to rescue disease lethality and to correct cholesterol and triglyceride accumulation in multiple organs and blood. Finally, using liver transcriptomic and biochemical analysis, we showed mitochondrial impairment in Lipa-/- mice and its recovery by gene therapy. Overall, our in vivo gene therapy strategy achieves a stable long-term LAL expression sufficient to correct the disease phenotype in the Lipa-/- mouse model and offers a new therapeutic option for LAL-D patients.
Insulin level regulators may affect cognitive ability caused by motion sickness: an experimental study
Authors: Zhong Mengyu , Zhu Jian , Zhang Bohan , Shen Hui , Li Hongxia , Tang Yuxiao , Nie Shuang , Mo Fengfeng
Published: July 2024

Abnormal acceleration induced motion sickness (MS) and elevated blood glucose levels, showing obviously cognitive impairments. The mechanism of cognitive impairment caused by MS is still unclear. Here, blood metabolite detection, insulin level regulators, stress hormones, cytokines and MS assessment were conducted for the population and MS model rats, correlation analysis of motion sickness index (MSI) and above factors were conducted by Pearson correlation analysis. We found glucose after acceleration was positively correlated with Graybiel’s score. Insulin and leptin levels decreased, while ghrelin level increased after acceleration in both human and rat groups. We injected insulin level regulators into rats before being exposed to acceleration, the results showed that MSI of the insulin group (INS) was significantly lower than rotation group (ROT), streptozotocin group (STZ) and streptozotocin & insulin group (SINS). MSI in STZ was higher than ROT and INS. Rats injected with ghrelin showed higher MSI than the control group and (D-LYS3)-GHRP-6 (ghrelin antagonist) group. Acceleration stimulation induced phosphorylation of insulin receptor substrate 1 (IRS1) and expression of synaptic protein in hippocampus. We also found that the insulin microinjection into hippocampus prevented MS symptoms and cognitive ability as measured by the MSI, the total distance of the Open Field Test and correct choice of T-maze. Our study indicates that insulin and insulin level regulators can affect MS symptoms and cognitive ability.
Elucidating the role of cGAS in pan-cancer using integrated bioinformatics and experimental approaches
Authors: Lian Zhen , Liu Xue , Li Xue
Published: July 2024

cGAS play an important role in regulating both the tumor immune responses and DNA damage repair. Nevertheless, there was little research that comprehensively analysis the correlation between cGAS and tumor microenvironment, immune cell infiltration, and DNA damage repair in different cancers. In this study, The Cancer Genome Atlas (TCGA) and Cancer Cell Line Encyclopedia (CCLE) data were used to analysis the mRNA expression and genomic alterations of cGAS in pan-cancer. HPA database were used to explore the protein levels of cGAS in normal tissues and cancers. Correlation analysis were performed to explore the role of cGAS in interferons expression, immune cells infiltrations, DNA damage repair, and predictive immune markers. The prognostic value of cGAS was analyzed using survival data from the TCGA, Kaplan-Meier plotter database and PrognoScan database. Lastly, the role of cGAS in DNA damage repair signaling and interferon signaling was validated in NSCLC cell lines. The results showed that cGAS was widely expressed in human normal tissues and various cancers, and the expression of cGAS was significantly upregulated in almost all of the solid cancers. Genomic analysis indicated that the expression of cGAS was positively correlated with copy number levels, while negatively correlated with the methylation levels of cGAS promoter. In addition, the level of cGAS was positively correlated with the type I interferons expression, infiltration levels of most immune cell types, TMB and MSI levels, stromal and immune scores, and DNA damage repair gene sets including nonhomologous end joining and homologous recombination pathway. Survival analysis indicated that cGAS levels were associated with patients prognosis in several cancers. Lastly, in vitro study showed knockdown of cGAS expression inhibits the DNA damage repair signaling pathway and interferon signaling in NSCLC. In conclusions, cGAS is wildly activated in human cancers, which might participate in regulating cancer immunity and DNA damage repair. cGAS could be used as an effective target for cancer treatment, and might be a potential predictive immune marker.
Simulation of Artificial Lighting Using Dialux Evo to Evaluate Lighting Conditions and Electricity Consumption in Handicraft Rooms
Authors: Saffar May Al
Published: July 2024

This research paper investigates the role and contribution of artificial lighting on handicraft centers in the process of crafts making with limited daylight. These centres were designed to shed light on local handicraft manufacturing and display. The objective was to evaluate the artificial lighting performance, and its impacts on the craftsperson's visual comfort concerning the recommended lighting levels in the given setting, as well as the overall electricity consumption. Hence, a mixed method of case-study analysis was used to evaluate the daylight factor, and the existing artificial lighting layout and illumination level, site documentation through photographs and informal conversations was used to explore the craftsperson’s perception and visual experience, and computer simulation using Dialux evo lighting design software was applied to evaluate the existing lighting levels and propose new lighting solutions for better illumination distribution and electricity conservation. Three handicraft units in Al Jasra Handicraft Centre, Bahrain were selected: gypsum engraving, textile weaving, and pottery-making crafts units. The units were selected based on the level of difficulty and recommended illumination levels. The findings suggest that illumination in the existing handicraft units exceeds the recommended levels, which negatively affects the artisans’ visual comfort and consequently impacts the quality of the produced products. Moreover, excessive lighting may increase the warmness of the indoor environment and increase electricity consumption. The difficulty in creating an optimum lighting design may reside in a combination of factors: the type of handicraft and its level of detail, the type of luminaires and its mounted height from the work plane, as each craft has a specific setting and requirements. Finally, a new lighting layout and new lighting fixtures are suggested, considering the lighting layers to create the best atmosphere to meet the functional and aesthetical demands required in a handicraft unit. In addition, this study’s ambition is to provide some lighting design directions for architects, handicraft centres, and artisans in Bahrain and beyond.
Elderly patient with squamous cell carcinoma of the lung with irAE-associated hidden myocarditis: A case report
Authors: Kodaka Norio , Hayashi Noriyuki , Asakawa Nanae , Yoshida Masahiro , Watanabe Kayo , Matsuse Hiroto
Published: July 2024

Background: Immune checkpoint inhibitors (ICIs) are the standard therapy for various types of cancer. One of them, durvalumab, as a programmed cell death ligand 1 (PD-L1) inhibitor, is commonly used to treat pulmonary malignancies. It has a wide range of known side effects, known as immune-related adverse events (irAEs). Myocarditis as an irAEs is rare but fatal. Currently, there is a paucity of reports on myocarditis as an irAE after durvalumab treatment in elderly patients.
Case presentation: The patient was a 79-year-old female with stage Ⅲb squamous cell lung carcinoma and myocarditis as an irAE after durvalumab treatment.
She had completed two cycles of carboplatin and TS-1 and received 50 Gy of radiation. After combined chemotherapy and radiotherapy (CCRT), she was administered 10 mg/kg of durvalumab every two weeks as maintenance therapy. After eleven courses over five months of durvalumab, despite the absence of complaints, she experienced a significant decline in cardiac function as observed via echocardiography. Blood tests revealed elevated levels of high-sensitivity cardiac troponin T(hs-cTn). The diagnosis of myocarditis was confirmed through a myocardial biopsy, indicating that it was an irAE following durvalumab therapy. Her myocarditis improved with the discontinuation of durvalumab treatment and the administration of steroid therapy.
She has been successfully treated for lung cancer for more than two years without flare-up of myocarditis or lung cancer deterioration, although no treatment for lung cancer has been attempted since the occurrence of myocarditis.
Conclusion:In patients on ICIs, especially elderly patients, it is important to pay attention to irAEs and perform periodic electrocardiograms and ECGs, even in asymptomatic persons, for early detection and prognosis improvement.
Phase II trial evaluating the long-term efficacy and peripheral sensory neuropathy of adjuvant XELOX in Japanese patients
Authors: Hata Taishi , Umemura Mamoru , Danno Katsuki , Yoshioka Shinichi , Matsuda Chu , Kagawa Yoshinori , Shingai Tatsushi , Suzuki Yozo , Tei Mitsuyoshi , Tanida Tsukasa , Komori Takamichi , Okamura Shu , Ota Hirofumi , Takemoto Hiroyoshi , Ogino Takayuki , Miyoshi Norikatsu , Yamamoto Hirofumi , Murata Kohei , Doki Yuichiro , Eguchi Hidetoshi
Published: July 2024

Adjuvant oxaliplatin plus capecitabine (XELOX) therapy is recommended for patients with curatively resected colon cancer. However, prospective data on its practical application in Japanese patients are limited. Therefore, this study aims to conduct a long-term clinical evaluation of the efficacy and safety of adjuvant XELOX in patients with curatively resected stage III colon cancer (MCSCO-1024). This prospective, multicenter, open-label, single-arm phase II study enrolled patients with curatively resected stage III colon cancer. The treatment protocol comprised a 120-minute intravenous infusion of oxaliplatin (130 mg/m2) on day 1 and two divided doses of oral capecitabine (2000 mg/m2/day) for 14 days in a 3-week cycle, totaling eight cycles (24 weeks). The primary endpoint was 3-year disease-free survival (DFS), and the secondary endpoints were 5-year overall survival and long-term prognosis of peripheral sensory neuropathy. In total, 196 patients were enrolled between November 2011 and August 2014 (34 months). The 3-year DFS rate was 73%, and the 5-year overall survival rate was 87%. The overall incidence of peripheral sensory neuropathy was 17%, with a 1% rate of grade 3 neuropathy after 5 years. Adjuvant XELOX demonstrated utility and safety in the clinical management of Japanese patients with stage III colon cancer.
Innate immune signatures in the nasopharynx after SARS-CoV-2 Infection and links with the clinical outcome of COVID-19 in Omicron-dominant period
Authors: Cha Hyunkyung , Lee Chan Mi , Kim Sujin , Kang Chang Kyung , choe Pyoeng Gyun , Jeon Yoon-Kyung , Jo Hyeon Jae , Kim Nam Joong , Park Wan Beom , Kim Hyun Jik
Published: July 2024

While severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is characterized by impaired induction of interferons (IFNs) and IFN-stimulated genes (ISGs), the interferons (IFNs) and IFN-stimulated genes (ISGs) in upper airway is essential to restrict the spread of respiratory virus. Here, we identified the prominent IFN and ISG upregulation in the nasopharynx (NP) of mild and even severe COVID-19 patients (CoV2+) in Omicron era and to compare their clinical outcome depending on the level of IFNs and ISGs. Whereas the induction of IFNB was minimal, transcription of IFNA, IFNG, and IFNLs was significantly increased in the NP of CoV2 + patients. IFNs and ISGs may be more upregulated in the NP of CoV2 + patients at early phases of infection according to viral RNA levels and this is observed even in severe cases. IFN-related innate immune response might be characteristic in macrophages and monocytes at the NP and the CoV2 + patients with higher transcription of IFNs and ISGs in the NP showed a correlation with good prognosis of COVID-19. This study presents that IFNs and ISGs may be upregulated in the NP, even in severe CoV2 + patients depending on viral replication during Omicron-dominant period and the unique IFN-responsiveness in the NP links with COVID-19 clinical outcomes.
Characteristics of incident coronary artery disease in patients undergoing atrial fibrillation ablation
Authors: Ikeda Hiroyuki , Hasegawa Kanae , Uzui Hiroyasu , Mukai Moe , Tama Naoto , Ishida Kentaro , Tada Hiroshi
Published: July 2024

Background
Few reports have provided detailed characteristics of incident coronary artery disease and its risk factors in patients undergoing ablation for atrial fibrillation..
Methods
Patients undergoing ablation for atrial fibrillation with no documented coronary artery disease were retrospectively studied at our institution. Patients were divided into two groups: those in whom significant stenosis was detected incidentally on coronary angiography performed at the same time as ablation and those in whom it was not, and the detection rate and its predictors were examined.
Results
Of the 550 patients, 30 patients showed incidental coronary artery disease (CAD) (detection rate: 3.6%). We compared clinical data between these 30 patients (ABL-CAD group) and the 520 patients (ABL-non-CAD group) who displayed no significant stenosis on coronary angiography. In multivariate analysis, age, hemoglobinA1c (HbA1c) and high-density lipoprotein cholesterol (HDL-chol.) were predictive factors (odds ratio: 1.08, 2.43, 1.58, 95% CI: 1.01–1.14, 1.53–3.86, 0.92–0.99, P value: 0.014, 0.004, 0.024, respectively) for identification of CAD. Multivariate analysis based on cut-off values from receiver operating characteristic analysis identified age, HbA1c ≥ 6.1%, HDL ≤ 49 mg/dL as predictors (odds ratios: 1.06, 4.04, 3.07; 95% confidence intervals [CIs]: 1.00–1.12, 1.58–10.3, 1.18–8.01; P = 0.04, P < 0.01, P = 0.021, respectively). Area under the curve was significantly greater for age plus HbA1c ≥ 6.1% plus HDL ≤ 49 mg/dL (0.810) than for age alone (0.672; P = 0.005).
Conclusion
Patients undergoing ablation for atrial fibrillation appear likely to have CAD if HbA1c is ≥ 6.1% and HDL-chol is ≤ 49 mg/dL.
A Comparison of Yoga and Clinical Pilates Exercise Methods in Women with Breast Cancer-Related Lymphedema: A Randomized Controlled Trial
Authors: Zabit Ferdiye , Iyigun Gozde , Malkoc Mehtap
Published: July 2024

Purpose: This study conducted a comparison of the benefits of yoga and clinical Pilates exercise methods, both administered with compression stockings, on lymphedema, muscle strength, upper extremity functions, and quality of life in women with BCRL
Methods: 28 individuals with breast cancer-related lymphedema were included in the study. The upper extremity lymphedema severity of the individuals was evaluated by circumference and volumeter measurement. Upper extremity muscle strength was measured with an isokinetic dynamometer (HUMAC/NORM Testing & Rehabilitation System, CSMD). The disabilities of the arm, shoulder, and hand (DASH) questionnaire was used to evaluate upper extremity functions, and the Breast Cancer-Specific Quality of Life Questionnaire (QLQ-BR23) was used to evaluate the quality of life.
Results: In our study, it was determined that compared to pre-treatment, the severity of lymphedema decreased more in the yoga and clinical Pilates groups than in the control group (P4 = .034). In extremity with lymphedema (EwLE), the clinical Pilates group had the greatest improvement in muscular strength for internal rotation (IR) (P3=.016, P4=.037), while the upper extremity functions were shown to be higher in the yoga and clinical Pilates groups compared to the control group (P3=.008, P4=.004). It was found that the quality of life subscale symptom scores, breast symptom (P3=.006, P4=.028) and arm symptom (P2=.004, P3=.008, P4=.002) scores in the yoga group, and arm symptom (P3=.012, P4=.002) scores in the clinical Pilates group showed a positive increase compared to the control group.
Conclusion: Both yoga and clinical Pilates exercises, with the use of compression stockings, have demonstrated favorable results in women with BCRL, showing great potential for treatment. Clinical Pilates exercises have been determined to be useful in several physical aspects, including the reduction of lymphedema, and the improvement of muscle strength and upper extremity functions. On the other hand, the emotional components of quality of life can be effectively improved by yoga exercises.
Trial Registration Number: NCT04824807 ,October 29, 2021
A review of placental histology for infants with hypoxic ischemic encephalopathy compared with healthy controls: A retrospective case-control study
Authors: Fox Aine , Doyle Emma , Reynolds Adam , Geary Michael , Cuzzilla Rocco , Hayes Breda
Published: July 2024

Objective
The role of the placenta in the development of hypoxic ischaemic encephalopathy (HIE) remains undefined. There is limited research comparing placental histology for infants with HIE and healthy controls. This is limiting our ability to understand its role in HIE. This study aimed to report the differences in placental histology between infants with HIE and healthy controls.
Study Design
A case-control study of (near-) term infants with moderate/severe HIE and healthy controls at a single tertiary NICU. Placental histology was reviewed by one perinatal histopathologist using consensus guidelines.
Results
Seventy-four cases and 98 controls were included. Cases had a higher incidence of pathology, including fetal vascular malperfusion, histological chorioamnionitis and delayed villous maturation.
Conclusion
This study demonstrates a higher incidence of placental pathology for infants born with HIE suggesting that the placenta is an important factor in the pathogenesis of HIE. Further research is required to delineate this relationship.
Propionibacterium acnes related endophthalmitis and HFE gene variation
Authors: Gao Ling , Feng Keyi
Published: July 2024

Background
To report a case of propionibacterium acnes endophthalmitis (PAE) associated with HFE gene mutation.
Case presentation
A 44-year-old man presented with painless binocular vision loss 5 months after cataract surgery with a previous diagnosis of binocular retinitis pigmentosa. It was initially diagnosed as noninfectious uveitis and treated with methylprednisolone. One month later, he experienced sudden loss of visual acuity and grey patchy opacity surrounding the capsular and intraocular lens implantation in the left eye. The next generation sequencing testshowed the presence of propionibacterium acnes (PA) in his aqueous humor of a very high sequence. The patient improved after anti-infective treatment. Genetic tests showed mutations in EYS gene and HFE gene.
Conclusion
HFE gene mutation might promote the intraocular growth and reproduction of PA by increasing the concentration of iron ions, leading to PAE in this post-operation patients with normal immune function.
Melt Focusing and Assimilation Along the Lithosphere-Asthenosphere Boundary Beneath Axial Volcano
Authors: Kent Graham , Arnulf Adrien , Singh Satish , Carton Helene , Harding Alistair , Saustrup Steffen
Published: July 2024

Beneath oceanic spreading centres, the lithosphere-asthenosphere boundary (LAB) acts as a permeability barrier that focuses the delivery of melt from deep within the mantle towards the spreading axis1. At intermediate- to fast-spreading ridge crests, the multichannel seismic reflection technique has imaged a nearly flat, 1-2 km wide axial magma lens (AML)2 that defines the uppermost section of the LAB3, but the nature of the LAB deeper into the crust has been more elusive with some clues gained from tomographic images, providing only a diffuse view of a wider halo of lower velocity material seated just beneath the AML4. Here we present three-dimensional (3-D) seismic reflection images of the LAB extending deep (5-6 km) into the crust beneath Axial Volcano, located at the intersection of the Juan de Fuca Ridge and Cobb-Eickelberg Hotspot. The geometry of the LAB is funnel-shaped, representing a magma assimilation front that is thermally-controlled. The morphology of the LAB, in combination with failure surfaces deep within Axial Volcano, highlights the focusing of hotspot- and mid-ocean spreading centre-related magmatism towards the centre of the volcano, controlling both eruption and hydrothermal processes, and the chemical composition of erupted lavas5. Our discovery of a funnel-shaped, crustal LAB suggests that thermally-controlled magma assimilation could be occurring along this surface at other volcanic systems such as Iceland.
Safety and effectiveness of transperineal puncture guided by a biplane intracavitary ultrasonic probe in the treatment of male rectovesical pouch effusion
Authors: Liu Shuqi , Qu Heming , Zhao Xinshu , Wang Peiwen , Teng Deng-Ke , Liu Junzhi
Published: July 2024

The aim of this study was to demonstrate and evaluate the safety and efficacy of transperineal puncture guided by a biplane intracavitary ultrasonic probe in the treatment of male rectovesical pouch effusion in which transabdominal percutaneous access could not be established because of overlying structures. We included fifteen male patients with rectovesical pouch effusion included in this study. The safety of the puncture was evaluated from the occurrence of complications during puncture. For effectiveness, the success rate of one-time puncture and paired t tests were performed to compare the changes in temperature as well as changes in white blood cell count and granulocyte count before and after puncture. We considered a P < 0.05 to indicate statistical significance. The results showed there was a statistically significant difference in the change in temperature as well as the white blood cell count and granulocyte count before and after puncture (P = 0.000, respectively). All patients were successfully treated with one-time transperineal puncture and drainage under the guidance of a biplane intracavitary ultrasonic probe without experienced any complications. Therefore, transperineal puncture guided by a biplane intracavitary ultrasonic probe could be a reliable choice for the treatment of male rectovesical pouch effusion.