bluuebunny/crossref_metadata_2025 huggingface dataset:
Closure of a Gastropleural Fistula Using Advanced Endoscopy
Authors: Vakil Deep P. , Palacio Jennifer , Motta Monique , Shatawi Zaineb N. , Colvin Juliana L. , Llaguna Omar H.
Published: April 2024

Gastropleural fistulas are rare complications with significant mortality and morbidity. There are limited reports on the successful management of gastropleural fistulas with advanced endoscopic procedures. The following case of a 75-year-old woman with a history of recurrent pseudomyxoma peritonei secondary to ruptured low-grade appendiceal mucinous neoplasm status post cytoreductive surgery highlights the successful treatment of a gastropleural fistula with endoscopic suturing.
A Threat to Cohesion: Intragroup Affective Polarization in the Context of Intractable Intergroup Conflict
Authors: Harel Tal Orian , Nir Nimrod , Vandermeulen Daan , Maoz Ifat , Halperin Eran
Published: April 2024

Growing affective polarization, or animosity between competing ideological groups, threatens to tear apart democratic societies worldwide. In nations that are facing external conflicts, the threat arising from these conflicts may boost internal cohesion and potentially reduce the internal threat of fragmentation. However, in the current study, we analyze survey datasets from two societies embedded in intractable conflicts, South Korea ( N = 897) and Israel ( N = 504), and demonstrate that gaps in the perception of the external threat between competing ideological groups are related to higher levels of affective polarization within these societies. We also find support for a mechanism that explains this trend: an internal threat from the ideological outgroup. We discuss the implications of our findings for the study of conflicts' impact on intragroup processes, specifically affective polarization, and for the understanding of how such processes might perpetuate the conflict itself.
Evidence presentation in suspect interviews: A review of the literature
Authors: Kelly Christopher E , Parker Margarita , Meehan Nathan , McClary Michael
Published: April 2024

This review organises the literature on presenting evidence in police interviews for researchers and practitioners to capture the breadth of the topic, and it is organised around the question of why evidence is presented during an interview. The literature was also coded for what type of evidence is presented and with what technique, when evidence is presented, and how it is presented. We found no support for the notion that presenting evidence will overcome resistance and is likely to increase it, presenting evidence gradually and in a challenging manner is the most effective approach to credibility assessment and information disclosure.
The effect of viewing visual cues in a listening comprehension test on second language learners’ test-taking process and performance: An eye-tracking study
Authors: Kwon Suh Keong , Yu Guoxing
Published: April 2024

In this study, we examined the effect of visual cues in a second language listening test on test takers’ viewing behaviours and their test performance. Fifty-seven learners of English in Korea took a video-based listening test, with their eye movements recorded, and 23 of them were interviewed individually after the test. The participants viewed the visual cues longer than the items in the multiple-choice questions. Looking at the correct answer choice was related to a higher test score, while looking at the speaker(s) in the video and the distractors of the test items to a lower test score. Viewing the PowerPoint slides showed mixed effects on test performance, depending on different eye-movement measures. Stimulated-recall interviews shed further light on the possible reasons for the different patterns of the participants’ eye movements. Overall, the participants held the positive view that the visual cues aided them in comprehending the aural input and in completing the listening tasks more successfully. We discuss these findings in relation to the authenticity of tasks and the construct relevance of video-based listening tests.
Self-Healing Characteristics of Polyvinyl Alcohol-Fiber-Reinforced Hot Mix Asphalt for Enhanced Pavement Durability
Authors: Afridi Hassan Farooq , Khattak Muhammad Jamal
Published: April 2024

Pavement maintenance presents significant financial challenges, driving researchers to explore innovative approaches that can prolong pavement service life and reduce costly interventions. The objective of this research is to examine the feasibility of utilizing polyvinyl alcohol (PVA) fibers to self-heal asphalt pavements. A comprehensive mechanical testing strategy was developed to evaluate the self-healing capability of several hot mix asphalt (HMA) mixtures at the micro- and macro-level. Moreover, to assess the healing behavior of macro fractures in PVA-fiber-reinforced HMA, semi-circular bending (SCB) specimens were loaded until peak load and then allowed to heal at varying time intervals and temperatures for several loading cycles. Healing indices developed based on SCB stiffness, strength, and beam fatigue technique were utilized to measure the self-healing ability of control and reinforced mixtures. By comparing different concentrations of PVA fibers with a control HMA, the optimal fiber dosage was determined based on newly developed healing indices. This study also investigated the impact of healing time and different temperatures on healing. The results demonstrated that PVA fibers expedited the healing process, effectively healing macro-, meso-, and micro-cracks. The most effective recovery occurred with 0.3% fiber content at 40°C for a 2 h duration. Incorporating PVA fibers into asphalt pavements presents a promising solution for extending pavement service life and can be helpful in reducing maintenance costs.
Cactus-like ZnO decorated UHMWPE fibers to improve the strength and toughness of polyurethane matrix composites
Authors: Li Weiwei , Song Wenhu , Li Shiting , Wang Xiaoyu
Published: April 2024

Poor interfacial force is an important factor in preventing the development of fibers reinforced polymer composites. Fiber morphology design is an effective way to improve the interfacial property of composites. The development of nature has carried out the natural selection of survival of the fittest for organisms, and most of the surviving organisms have excellent structures and functions, which comes up with a new idea for the design of new reinforcement structure. Inspired by the cactus structure, we have prepared a new structural UHMWPE fiber reinforcement, which was characterized by a mass of cactus-like ZnO (C-ZnO) crystals decorated the UHMWPE fiber surface. The experimental results showed that the strength and toughness of C-ZnO UHMWPE fibers reinforced rigid polyurethane (RPU) composites were significantly improved. The satisfactory results were attributed to the cactus-like ZnO on the UHMWPE fiber surface, which could form a complex interfacial structure with the PRU matrix to increase the interface strength and the crack expansion paths.
Drivers of Involuntary Career Changes: A Qualitative Study of Push, Pull, Anti-Push, and Anti-Pull Factors
Authors: Brazier Caroline Éliane , Masdonati Jonas , Borges André , Fedrigo Laurence , Cerantola Marine
Published: April 2024

Although research on work transitions is extensive, little is known about the specific challenges of involuntary career changes. This study focused on how people articulate push, pull, anti-push, and anti-pull factors when facing an involuntarily triggered career change. We conducted 19 semistructured interviews with people forced to change careers due to health issues, migration, or unemployment in Switzerland. Through a consensual qualitative analysis, we showed that career changes were driven (i.e., facilitated or inhibited) by participants’ interests, values, or skills. This resulted in five types of processes of career change, depending on whether participants were aiming to maintain their values, update their values, transpose their interests, resuscitate forgone interests, or valorize their skills despite the involuntary nature of the change they were undergoing. Overall, findings stressed individuals’ struggle to regain a sense of control when having to face a career change. Limitations and implications are discussed.
A Research Note on Suicidal Behavior as a Precursor to Domestic Homicide, With a Coda on Trends in Femicide Before, During and After COVID
Authors: Strang Heather
Published: April 2024

This article briefly reviews the difficulties of predicting and preventing domestic homicide. It considers the evidence on offender prior suicidal behaviour as a precursor. It includes findings from the 1950s and 1960s as well as the most recent findings on links between suicide ideation and domestic homicide intent. It also reviews ways in which these links can be further explored and operationalised to prevent future harm. It concludes with reflections on the effect of Covid on femicide trends.
Of Practices and (Micro)politics: Challenges of Organic Waste Segregation in Dschang, Cameroon
Authors: Kongnso Eric Moye , Yemmafouo Aristide , Moumbe Joël Sagne , Makamté Kakeu–Tardy Rolande Christelle , Sahakian Marlyne , Véron René
Published: April 2024

Waste generation in Sub-Saharan Africa is increasing rapidly. While biodegradable waste remains predominant, it is rarely treated separately by municipal solid waste management systems, thus foregoing the possibility to reduce the volume going to landfills or dumpsites. This paper discusses the unique case of the small city of Dschang, Cameroon, where the municipality operates two central composting plants that treat about 20% of the city’s household and restaurant waste. Using Urban Political Ecology and Social Practice Theory, this article studies waste flows, waste practices, material arrangements, power relations, social norms, institutional dynamics, and policies to identify opportunities and obstacles for organic waste sorting at the level of households and restaurants. Our analysis draws upon qualitative and quantitative data and points to the importance of the availability of multiple waste bins and monetary compensation for organic waste sorting. These factors have also facilitated the development of an informal waste sector, which might use up to 20% of the city’s waste as animal feed and for home/farm composting. However, complex relations between multiple actors and the national policy framework complicate the emergence of organic waste segregation at source as a common practice. In this way, the study shows that solid waste management is also a matter of power and (micro)politics.
Emergency Nurses’ Experience Providing Care and Perceptions About Using Telemedicine for Sexual Assault Patients
Authors: Walsh Wendy A. , Allison M. Kathryn , Zielinski Melissa , Searcy-Lyle Sherrie
Published: April 2024

Most emergency medical clinicians are not trained to conduct forensic sexual assault exams yet are often the first to care for survivors of recent sexual assault. Before the implementation of live sexual assault nurse examiner (SANE) consultation provided via telemedicine (“teleSANE”) in one state, results of an online survey of emergency nurses ( N = 116) found only 13% felt extremely confident providing quality forensic sexual assault examinations. Two-thirds of emergency nurses felt using teleSANE during sexual assault care would support their clinical decision-making skills. Findings suggest that teleSANE may be a promising strategy to improve access to specialized sexual assault care.
Surgical management of a case of non-resolving bullous retinal detachment due to probable Vogt-Koyanagi-Harada syndrome
Authors: Dutta Majumder Parthopratim , Shah Mauli , Sen Parveen
Published: April 2024

A 45-year-old male with Vogt-Koyanagi-Harada (VKH) syndrome presented with vision loss in his right eye after discontinuing treatment during the COVID-19 pandemic. He was found to have bullous retinal detachment (RD) in the right eye and was started on subcutaneous adalimumab with oral corticosteroid following three doses of pulse corticosteroid. But when RD did not resolve after 4 months of treatment and ultrasound B scan showed bullous RD with retino-retinal adhesion, he was planned for surgical intervention. During surgery, there was retino-retinal adhesions due to long-standing “kissing exudative RD”, causing non-settling exudative RD. Following surgery, the vision improved to 2/60, with attached retina. The patient has been under follow-up with us for the last one year now and developed no recurrence of RD till now. This case emphasises the significance of retinoretinal adhesion in long-standing bullous RD that does not respond to conventional aggressive medical therapy.
ProtoExplorer: Interpretable forensic analysis of deepfake videos using prototype exploration and refinement
Authors: Bouter Merel de Leeuw den , Pardo Javier Lloret , Geradts Zeno , Worring Marcel
Published: April 2024

In high-stakes settings, Machine Learning models that can provide predictions that are interpretable for humans are crucial. This is even more true with the advent of complex deep learning based models with a huge number of tunable parameters. Recently, prototype-based methods have emerged as a promising approach to make deep learning interpretable. We particularly focus on the analysis of deepfake videos in a forensics context. Although prototype-based methods have been introduced for the detection of deepfake videos, their use in real-world scenarios still presents major challenges, in that prototypes tend to be overly similar and interpretability varies between prototypes. This paper proposes a Visual Analytics process model for prototype learning, and, based on this, presents ProtoExplorer, a Visual Analytics system for the exploration and refinement of prototype-based deepfake detection models. ProtoExplorer offers tools for visualizing and temporally filtering prototype-based predictions when working with video data. It disentangles the complexity of working with spatio-temporal prototypes, facilitating their visualization. It further enables the refinement of models by interactively deleting and replacing prototypes with the aim to achieve more interpretable and less biased predictions while preserving detection accuracy. The system was designed with forensic experts and evaluated in a number of rounds based on both open-ended think aloud evaluation and interviews. These sessions have confirmed the strength of our prototype-based exploration of deepfake videos while they provided the feedback needed to continuously improve the system.
Effectiveness and Safety of Endoanchors in Abdominal and Thoracic Endovascular Aneurysm Repair: A Systematic Review and Meta-analysis
Authors: Tang Esther Wai Chi , Lau Arthur Chak Kai , Cheng Joshua Cheuk Hei , Wong Joseph Chi-Yeung , Chan Yiu Che
Published: April 2024

Purpose:

This systematic review aimed to summarize the effectiveness and safety of endoanchor, a stabilizing device for the proximal endograft designed to prevent endoleak and stent migration in endovascular aneurysm repair (EVAR) and thoracic endovascular aneurysm repair (TEVAR).

Materials and methods:

A systematic review and meta-analysis was conducted per the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guideline. Literature up to May 31, 2023 was searched and independently screened from 4 databases. Data were pooled for meta-analysis. Primary outcomes included intraoperative and follow-up endoleak, stent migration, and reintervention rates; sac regression; and 30-day all-cause mortality.

Results:

Sixteen EVAR (n=1145) and 6 TEVAR studies (n=163) using the Heli-Fx EndoAnchor system were included from 2225 retrieved records. For EVAR patients (mean follow-up=11.9 months), the endoleak, graft migration, and reintervention rates were 3.97% (95% confidence interval [CI]=0.36%-1.99%), 0.004% (95% CI=0.00%-0.76%), and 5.43% (95% CI=0.86%-12.54%), respectively. The endoleak rates for primary and revision EVAR were 0.16% (95% CI=0.00%-1.65%) and 3.60% (95% CI=0.14%-9.72%), respectively. Only 4 cases of 30-day mortality (n=4) were reported in the literature. For TEVAR patients, the endoleak, stent migration, and reintervention rates were 7.4% (95% CI=0.03%-0.13%), 0.2% (95% CI=0.00%-0.06%), and 17.1% (95% CI=0.01%-0.45%), respectively. The 30-day mortality was 0.9% (95% CI=0%-0.12%).

Conclusions:

Endoanchor fixation in EVAR and TEVAR is effective and safe in preventing and treating endoleak and stent migration. The mortality is minimal in EVAR but higher in TEVAR.

Clinical Impact

Endoleak, graft migration, and reintervention in EVAR and TEVAR with endoanchor use were rare. Mortality in EVAR was low. The adjunctive deployment of endoanchors is an effective and safe means to prevent and treat endoleak and stent migration in EVAR and TEVAR. Yet, long-term efficacy and safety data and randomized controlled trials would be required to definitively recommend endoanchor use in routine clinical practice.
It Matters Who Starts the Fire in Mesial Temporal Lobe Epilepsy
Authors: Goodman Jeffrey H.
Published: April 2024

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From ‘demographic bomb’ to ‘silver tsunami’: Navigating global population shifts
Authors: Tragaki Alexandra
Published: April 2024

Just six decades ago, the world was experiencing remarkably high population growth rates, which led to the coining of the term ‘demographic bomb’ to describe concerns associated with population size. At the time, the global population was three billion. Since then, an extra billion people have been added every 12 years. However, the pre-eminent demographic challenge of the twenty-first century is population ageing, a global, irreversible and unprecedented trend. The number of people aged 65 and over has almost doubled since the turn of the century and currently accounts for 10% of the global population. An extra billion people are expected to age into the older category within the next 35 years. In Europe, half of the population is above 45 years of age, and the number of those above 65 years old is greater than the number of children under 15. Commonly referred to as the ‘silver tsunami’, it is feared that the increasing number of older people will have a destructive impact on economies and social systems. Never before have our lives been longer, our families smaller and our societies more multigenerational. The new reality of longevity requires a shift in how we approach ageing. This article explores ways to cope with the challenges of the silver era we are heading towards.
“Telling China's Story Well” Through Higher Education Along the New Silk Road
Authors: Seiwert Eva
Published: April 2024

Over recent decades, the government of the People's Republic of China (PRC) and Chinese academics have worked assiduously to increase the competitiveness of their academic institutions. Given the PRC's character as a one-party state, its domestic and international engagements must be understood in the context of the party's ambition of safeguarding and projecting its power, including by “telling China's story well.” Most research on China's efforts to “tell its story well” through higher education focuses on Australia and the US, while little empirical knowledge exists beyond. This article investigates the party-state's academic engagements, and especially supposed “sharp power” ambitions, in Germany and Kazakhstan as two other important economic partners of China. Through qualitative discourse analysis of primary documents, survey data, and semi-structured interviews, I highlight similarities and differences in China's approach and argue that the party-state focuses its sharp power activities in higher education on liberal democracies rather than autocracies.
The Role of the School Nurse in Social-Emotional Assessment and Intervention Using the MTSS Framework
Authors: Lytle Megan , Rau Wendy , Stoner Sara
Published: April 2024

Mental health needs in school are increasing and can affect every student. School nurses are in a perfect position to support social-emotional learning and implement coping strategies to aid in student success. This article features the implementation of social-emotional interventions in the school health office for all students using the multitiered systems of support (MTSS) framework. MTSS is an evidence-based framework that integrates prevention and tiered intervention with data-based problem-solving to meet the academic and behavioral needs of students. Through a tiered approach, all students receive the support they need to understand their emotions, recognize how strong emotions affect physical health, and how to cope. Because maladaptive coping can have an adverse effect on academics, social-emotional wellness is essential for students to be healthy, safe, and ready to learn.
The plasma proteome differentiates the multisystem inflammatory syndrome in children (MIS-C) from children with SARS-CoV-2 negative sepsis
Authors: Patel Maitray A. , Fraser Douglas D. , Daley Mark , Cepinskas Gediminas , Veraldi Noemi , Grazioli Serge
Published: April 2024

Background

The Multi-System Inflammatory Syndrome in Children (MIS-C) can develop several weeks after SARS-CoV-2 infection and requires a distinct treatment protocol. Distinguishing MIS-C from SARS-CoV-2 negative sepsis (SCNS) patients is important to quickly institute the correct therapies. We performed targeted proteomics and machine learning analysis to identify novel plasma proteins of MIS-C for early disease recognition.

Methods

A case-control study comparing the expression of 2,870 unique blood proteins in MIS-C versus SCNS patients, measured using proximity extension assays. The 2,870 proteins were reduced in number with either feature selection alone or with a prior COMBAT-Seq batch effect adjustment. The leading proteins were correlated with demographic and clinical variables. Organ system and cell type expression patterns were analyzed with Natural Language Processing (NLP).

Results

The cohorts were well-balanced for age and sex. Of the 2,870 unique blood proteins, 58 proteins were identified with feature selection (FDR-adjusted P < 0.005, P < 0.0001; accuracy = 0.96, AUC = 1.00, F1 = 0.95), and 15 proteins were identified with a COMBAT-Seq batch effect adjusted feature selection (FDR-adjusted P < 0.05, P < 0.0001; accuracy = 0.92, AUC = 1.00, F1 = 0.89). All of the latter 15 proteins were present in the former 58-protein model. Several proteins were correlated with illness severity scores, length of stay, and interventions (LTA4H, PTN, PPBP, and EGF; P < 0.001). NLP analysis highlighted the multi-system nature of MIS-C, with the 58-protein set expressed in all organ systems; the highest levels of expression were found in the digestive system. The cell types most involved included leukocytes not yet determined, lymphocytes, macrophages, and platelets.

Conclusions

The plasma proteome of MIS-C patients was distinct from that of SCNS. The key proteins demonstrated expression in all organ systems and most cell types. The unique proteomic signature identified in MIS-C patients could aid future diagnostic and therapeutic advancements, as well as predict hospital length of stays, interventions, and mortality risks.
Prominent transcriptomic changes in Mycobacterium intracellulare under acidic and oxidative stress
Authors: Park Hyun-Eui , Kim Kyu-Min , Shin Jeong-Ih , Choi Jeong-Gyu , An Won-Jun , Trinh Minh Phuong , Kang Kyeong-Min , Yoo Jung-Wan , Byun Jung-Hyun , Jung Myung Hwan , Lee Kon-Ho , Kang Hyung-Lyun , Baik Seung Cheol , Lee Woo-Kon , Shin Min-Kyoung
Published: April 2024

Background

Mycobacterium avium complex (MAC), including Mycobacterium intracellulare is a member of slow-growing mycobacteria and contributes to a substantial proportion of nontuberculous mycobacterial lung disease in humans affecting immunocompromised and elderly populations. Adaptation of pathogens in hostile environments is crucial in establishing infection and persistence within the host. However, the sophisticated cellular and molecular mechanisms of stress response in M. intracellulare still need to be fully explored. We aimed to elucidate the transcriptional response of M. intracellulare under acidic and oxidative stress conditions.

Results

At the transcriptome level, 80 genes were shown [FC] ≥ 2.0 and p < 0.05 under oxidative stress with 10 mM hydrogen peroxide. Specifically, 77 genes were upregulated, while 3 genes were downregulated. In functional analysis, oxidative stress conditions activate DNA replication, nucleotide excision repair, mismatch repair, homologous recombination, and tuberculosis pathways. Additionally, our results demonstrate that DNA replication and repair system genes, such as dnaB, dinG, urvB, uvrD2, and recA, are indispensable for resistance to oxidative stress. On the contrary, 878 genes were shown [FC] ≥ 2.0 and p < 0.05 under acidic stress with pH 4.5. Among these genes, 339 were upregulated, while 539 were downregulated. Functional analysis highlighted nitrogen and sulfur metabolism pathways as the primary responses to acidic stress. Our findings provide evidence of the critical role played by nitrogen and sulfur metabolism genes in the response to acidic stress, including narGHIJ, nirBD, narU, narK3, cysND, cysC, cysH, ferredoxin 1 and 2, and formate dehydrogenase.

Conclusion

Our results suggest the activation of several pathways potentially critical for the survival of M. intracellulare under a hostile microenvironment within the host. This study indicates the importance of stress responses in M. intracellulare infection and identifies promising therapeutic targets.
Continuation of chronic antiplatelet therapy is not associated with increased need for transfusions: a cohort study in critically ill septic patients
Authors: Fuchs Christian , Scheer Christian S. , Wauschkuhn Steffi , Vollmer Marcus , Meissner Konrad , Hahnenkamp Klaus , Gründling Matthias , Selleng Sixten , Thiele Thomas , Borgstedt Rainer , Kuhn Sven-Olaf , Rehberg Sebastian , Scholz Sean Selim
Published: April 2024

Background

The decision to maintain or halt antiplatelet medication in septic patients admitted to intensive care units presents a clinical dilemma. This is due to the necessity to balance the benefits of preventing thromboembolic incidents and leveraging anti-inflammatory properties against the increased risk of bleeding.

Methods

This study involves a secondary analysis of data from a prospective cohort study focusing on patients diagnosed with severe sepsis or septic shock. We evaluated the outcomes of 203 patients, examining mortality rates and the requirement for transfusion. The cohort was divided into two groups: those whose antiplatelet therapy was sustained (n = 114) and those in whom it was discontinued (n = 89). To account for potential biases such as indication for antiplatelet therapy, propensity score matching was employed.

Results

Therapy continuation did not significantly alter transfusion requirements (discontinued vs. continued in matched samples: red blood cell concentrates 51.7% vs. 68.3%, p = 0.09; platelet concentrates 21.7% vs. 18.3%, p = 0.82; fresh frozen plasma concentrates 38.3% vs. 33.3%, p = 0.7). 90-day survival was higher within the continued group (30.0% vs. 70.0%; p < 0.001) and the Log-rank test (7-day survivors; p = 0.001) as well as Cox regression (both matched samples) suggested an association between continuation of antiplatelet therapy < 7 days and survival (HR: 0.24, 95%-CI 0.10 to 0.63, p = 0.004). Sepsis severity expressed by the SOFA score did not differ significantly in matched and unmatched patients (both p > 0.05).

Conclusions

The findings suggest that continuing antiplatelet therapy in septic patients admitted to intensive care units could be associated with a significant survival benefit without substantially increasing the need for transfusion. These results highlight the importance of a nuanced approach to managing antiplatelet medication in the context of severe sepsis and septic shock.
Identifying high-risk neurological phenotypes in adult-onset classic monogenic autoinflammatory diseases: when should neurologists consider testing?
Authors: Silva Guilherme Diogo , Mahler João Vitor , da Silva Junior Sérgio Roberto Pereira , Mendonça Leonardo Oliveira , de Sá Barreto Lima Pedro Lucas Grangeiro , Nóbrega Paulo Ribeiro , Kok Fernando , Freua Fernando
Published: April 2024

Background

Monogenic autoinflammatory disorders result in a diverse range of neurological symptoms in adults, often leading to diagnostic delays. Despite the significance of early detection for effective treatment, the neurological manifestations of these disorders remain inadequately recognized.

Methods

We conducted a systematic review searching Pubmed, Embase and Scopus for case reports and case series related to neurological manifestations in adult-onset monogenic autoinflammatory diseases. Selection criteria focused on the four most relevant adult-onset autoinflammatory diseases—deficiency of deaminase 2 (DADA2), tumor necrosis factor receptor associated periodic fever syndrome (TRAPS), cryopyrin associated periodic fever syndrome (CAPS), and familial mediterranean fever (FMF). We extracted clinical, laboratory and radiological features to propose the most common neurological phenotypes.

Results

From 276 records, 28 articles were included. The median patient age was 38, with neurological symptoms appearing after a median disease duration of 5 years. Headaches, cranial nerve dysfunction, seizures, and focal neurological deficits were prevalent. Predominant phenotypes included stroke for DADA2 patients, demyelinating lesions and meningitis for FMF, and meningitis for CAPS. TRAPS had insufficient data for adequate phenotype characterization.

Conclusion

Neurologists should be proactive in diagnosing monogenic autoinflammatory diseases in young adults showcasing clinical and laboratory indications of inflammation, especially when symptoms align with recurrent or chronic meningitis, small vessel disease strokes, and demyelinating lesions.
Beyond gait speed: exploring the added value of Inertial Measurement Unit-based measurements of gait in the estimation of the walking ability in daily life
Authors: Felius R. A. W. , Wouda N. C. , Geerars M. , Bruijn S. M. , van Dieën J. H. , Punt M.
Published: April 2024

Background

Gait speed is often used to estimate the walking ability in daily life in people after stroke. While measuring gait with inertial measurement units (IMUs) during clinical assessment yields additional information, it remains unclear if this information can improve the estimation of the walking ability in daily life beyond gait speed.

Objective

We evaluated the additive value of IMU-based gait features over a simple gait-speed measurement in the estimation of walking ability in people after stroke.

Methods

Longitudinal data during clinical stroke rehabilitation were collected. The assessment consisted of two parts and was administered every three weeks. In the first part, participants walked for two minutes (2MWT) on a fourteen-meter path with three IMUs attached to low back and feet, from which multiple gait features, including gait speed, were calculated. The dimensionality of the corresponding gait features was reduced with a principal component analysis. In the second part, gait was measured for two consecutive days using one ankle-mounted IMU. Next, three measures of walking ability in daily life were calculated, including the number of steps per day, and the average and maximal gait speed. A gait-speed-only Linear Mixed Model was used to estimate the association between gait speed and each of the three measures of walking ability. Next, the principal components (PC), derived from the 2MWT, were added to the gait-speed-only model to evaluate if they were confounders or effect modifiers.

Results

Eighty-one participants were measured during rehabilitation, resulting in 198 2MWTs and 135 corresponding walking-performance measurements. 106 Gait features were reduced to nine PCs with 85.1% explained variance. The linear mixed models demonstrated that gait speed was weakly associated with the average and maximum gait speed in daily life and moderately associated with the number of steps per day. The PCs did not considerably improve the outcomes in comparison to the gait speed only models.

Conclusions

Gait in people after stroke assessed in a clinical setting with IMUs differs from their walking ability in daily life. More research is needed to determine whether these discrepancies also occur in non-laboratory settings, and to identify additional non-gait factors that influence walking ability in daily life.
Chronic hyperglycemia and intracranial meningiomas
Authors: Orešković D. , Madero Pohlen A. , Cvitković I. , Alen J.F. , Raguž M. , Álvarez-Sala de la Cuadra A. , Bazarra Castro G.J. , Bušić Z. , Konstantinović I. , Ledenko V. , Martínez Macho C. , Müller D. , Žarak M. , Jovanov-Milosevic N. , Chudy D. , Marinović T.
Published: April 2024

Meningiomas are among the most common primary tumors of the central nervous system. Previous research into the meningioma histological appearance, genetic markers, transcriptome and epigenetic landscape has revealed that benign meningiomas significantly differ in their glucose metabolism compared to aggressive lesions. However, a correlation between the systemic glucose metabolism and the metabolism of the tumor hasn’t yet been found. We hypothesized that chronic levels of glycaemia (approximated with glycated hemoglobin (HbA1c)) are different in patients with aggressive and benign meningiomas. The study encompassed 71 patients with de novo intracranial meningiomas, operated on in three European hospitals, two in Croatia and one in Spain. Our results show that patients with WHO grade 2 meningiomas had significantly higher HbA1c values compared to patients with grade 1 lesions (P = 0.0290). We also found a significant number of patients (19/71; 26.7%) being hyperglycemic, harboring all the risks that such a condition entails. Finally, we found a significant correlation between our patients’ age and their preoperative HbA1c levels (P = 0.0008, ρ(rho) = 0.388), suggesting that older meningioma patients are at a higher risk of having their glycaemia severely dysregulated. These findings are especially important considering the current routine and wide-spread use of corticosteroids as anti-edematous treatment. Further research in this area could lead to better understanding of meningiomas and have immediate clinical impact.
Giant retinal pigment epithelium tears with membranous nephropathy: a case report and literature review
Authors: Dou Rui , Chu Yanhua , Han Quanhong , Zhang Wei , Bi Xue
Published: April 2024

Background

Kidney and eye diseases may be closely linked. Tears of the retinal pigment epithelium (RPE) have been reported to be related to kidney diseases, such as IgA nephropathy and light-chain deposition disease. However, pigment epithelium tears associated with membranous nephropathy have not been reported or systematically analysed.

Case presentation

A 68-year-old man presented with decreased right eye visual acuity. Optical coherence tomography (OCT) revealed cystic macular edema, localized serous detachment of the retina and loss of the outer retinal structure in the right eye and retinal pigment epithelium detachment (PED) combined with serous detachment of the retina in the left eye. Fundus fluorescein angiography (FFA) and indocyanine green angiography (ICGA) revealed giant RPE tears in the right eye and exudative age-related macular degeneration in the left eye. The patient also suffered from severe membranous nephropathy-autoimmune glomerulonephritis. Renal biopsy immunofluorescence revealed a roughly granular pattern, with immunoglobulin G (IgA), immunoglobulin G (IgG), IgM, complement C3(Components 3), λ light chain and κ light chain subepithelial staining.

Conclusions

It is hypothesized that severe membranous nephropathy caused immune complex deposition on the surface of Bruch membrane, resulting in weakened adhesion between the RPE and Bruch membrane and impaired RPE pump function, combined with age-related macular degeneration, leading to giant RPE tears in the right eye. Close attention should be given to the ocular condition of patients with membranous nephropathy to facilitate timely treatment and avoid serious consequences.
Profiles of intuitive eating in adults: the role of self-esteem, interoceptive awareness, and motivation for healthy eating
Authors: Chammas Nancy , Brytek-Matera Anna , Tornquist Debora , Barreto Schuch Felipe , Bitar Zeinab , Malaeb Diana , Fawaz Mirna , Fekih-Romdhane Feten , Hallit Souheil , Obeid Sahar , Soufia Michel
Published: April 2024

Objective

Intuitive eating is an eating behavior that has recently come to use mainly in the young population. Knowing that the Lebanese cultural diet differs from other countries, the purpose of this study was to investigate if there is a relationship between self-esteem, interoceptive awareness, and motivation for healthy eating in a sample of Lebanese adults using a Latent Profile Analysis approach.

Design

Cross-sectional study.

Setting

Lebanese governorates.

Participants

359 Lebanese participants enrolled in this study (mean age: 22.75 ± 7.04 years, 40.1% males), through convenience sampling in several Lebanese governorates. Participants were asked to fill anonymously the following scales: The Intuitive Eating Scale (IES-2), the Rosenberg Self-Esteem Scale, the Multidimensional Assessment of Interoceptive Awareness Scale (MAIA), and the Motivation for Healthy Eating Scale (MHES).

Results

Our findings revealed four profiles: profile 1 (n = 67; 18.66%) characterized by high SE and intermediate interoceptive awareness and motivation for healthy eating; profile 2 (n = 86; 23.97%) presented high SE, interoceptive awareness, and motivation for healthy eating; profile 3 (n = 86; 23.96%) characterized by high SE, interoceptive awareness, and motivation for healthy eating; class 4 (n = 108; 30.08) described by low SE, intermediate interoceptive awareness, and motivation for healthy eating One-way analysis of variance did not observe a significant difference between the four profiles based on intuitive eating (F = 1.810; p = 0.145; ɳp2 = 0.015).

Conclusions

Among a sample of Lebanese people, four profiles of interoceptive awareness, motivation for healthy eating, and self-esteem were observed, with no difference concerning intuitive eating.
Arthroscopic cuff repair: footprint remnant preserving versus debriding rotator cuff repair of transtendinous rotator cuff tears with remnant cuff
Authors: Lee Jae Min , Ji Jong-Hun , Park Sang-Eun , Suh Dongwhan , Song Ki-Jeon
Published: April 2024

Background

In transtendinous full thickness rotator cuff tears (FTRCT) with remnant cuff, conventionally, cuff remnant of the greater tuberosity (GT) is debrided for better tendon to bone healing. However, larger cuff defect caused overtension on the repaired tendon. The purpose of this study was to compare the clinical outcomes and tendon integrity between remnant preserving and remnant debriding cuff repairs in the transtendinous FTRCT with remnant cuff.

Methods

From March, 2012 to October, 2017, a total of 127 patients who had the transtendinous FTRCT with remnant cuff were enrolled in this study. Rotator cuff tears were repaired arthroscopically, with patients divided into two groups: group I (n = 63), where rotator cuff remnants were preserved during the repair, and group II (n = 64), where the remnants were debrided during the repair. Clinical outcomes were assessed at the last follow-up (minimum 2 years) using the UCLA score, ASES score, SST score, Constant Shoulder score, and range of motion (ROM). The analysis of structural integrity and tendon quality was performed using the Sugaya classification on postoperative MRI scans at 8 months after surgery.

Results

At the final follow-up, UCLA, ASES, SST, and CS scores significantly improved from preoperative values to postoperative (all p < 0.05): UCLA (I: 19.6 ± 6.0 to 31.7 ± 3.2, II: 18.0 ± 5.7 to 31.5 ± 3.2), ASES (I: 54.3 ± 10.7 to 86.5 ± 12.5, II: 18.0 ± 5.7 to 85.8 ± 12.4), SST (I: 5.6 ± 2.8 to 10.2 ± 2.0, II: 5.0 ± 2.9 to 10.1 ± 2.5), CS (I: 74.0 ± 17.2 to 87.8 ± 9.7, II: 62.0 ± 19.2 to 88.3 ± 6.2). However, there were no significant differences between the two groups (p > 0.05). Also, remnant preserving cuff repair yielded significantly better tendon quality on postoperative MRI (p < 0.05). The incidence of re-tear (Sugaya’s Type IV and V) was not significantly different between the two groups (I:17% vs. II:19%; p = 0.053).

Conclusions

Remnant preserving rotator cuff repairs, which facilitate tendon-to-tendon healing, are superior in terms of tendon quality and are the preferred option for transtendinous FTRCT.

Trial registration

Retrospectively registered.
The role of lifestyle factors in the association between education and self-reported fibromyalgia: a mediation analysis
Authors: Benebo Faith Owunari , Lukic Marko , Jakobsen Monika Dybdahl , Braaten Tonje Bjørndal
Published: April 2024

Background

Socioeconomic status as measured by education, income, or occupation, has been associated with fibromyalgia but the underlying mechanism and the role of lifestyle factors are unclear. Thus, we examine the role of modifiable lifestyle factors (body mass index, physical activity, alcohol consumption and smoking) in the association between education and self-reported fibromyalgia.

Methods

We used data from 74,157 participants in the population-based prospective Norwegian Women and Cancer (NOWAC) study. Socioeconomic position, operationalized as years of educational attainment, and lifestyle factors were assessed via self-reported questionnaires. Multiple mediation analysis was used to decompose total effects into direct and indirect effects. Estimates were reported as hazard ratios (HRs) with 95% confidence intervals (CIs).

Results

The cumulative incidence of fibromyalgia was 3.2% after a median follow up time of 13 years. Fibromyalgia was inversely associated with years of educational attainment for ≤ 9 years (HR = 2.56; 95% CI 2.32–2.91) and for 10–12 years (HR = 1.84; 95% CI 1.72–2.02), compared with ≥ 13 years of education. Overall, all lifestyle factors together jointly mediated 17.3% (95% CI 14.3–21.6) and 14.1% (95% CI 11.3–18.9) of the total effect for ≤ 9 years and 10–12 years of education, respectively. Smoking and alcohol consumption contributed the most to the proportion mediated, for ≤ 9 years (5.0% and 7.0%) and 10–12 years (5.6% and 4.5%) of education.

Conclusion

The association between education and self-reported fibromyalgia was partly explained through lifestyle factors, mainly smoking and alcohol consumption.
Study on the differential hepatotoxicity of raw polygonum multiflorum and polygonum multiflorum praeparata and its mechanism
Authors: Huang Chaowen , Jiang Yu , Bao Qing , Wang Lu , Tang Lin , Liu Yanjuan , Yang Lei
Published: April 2024

Background

Polygonum multiflorum (PM), a widely used traditional Chinese medicine herb, is divided into two forms, namely raw polygonum multiflorum (RPM) and polygonum multiflorum praeparata (PMP), according to the processing procedure. Emerging data has revealed the differential hepatotoxicity of RPM and PMP, however, its potential mechanism is still unclear.

Methods

In our study, we investigated the differential hepatotoxicity of RPM and PMP exerted in C57BL/6 mice. First, sera were collected for biochemical analysis and HE staining was applied to examine the morphological alternation of the liver. Then we treated L02 cells with 5 mg / mL of RPM or PMP. The CCK8 and EdU assays were utilized to observe the viability and proliferation of L02 cells. RNA sequencing was performed to explore the expression profile of L02 cells. Western blotting was performed to detect the expression level of ferroptosis-related protein. Flow cytometry was used to evaluate ROS accumulation.

Results

In our study, a significant elevation in serum ALT, AST and TBIL levels was investigated in the RMP group, while no significant differences were observed in the PMP group, compared to that of the CON group. HE staining showed punctate necrosis, inflammatory cell infiltration and structural destruction can be observed in the RPM group, which can be significantly attenuated after processing. In addition, we also found RPM could decrease the viability and proliferation capacity of L02 cells, which can be reversed by ferroptosis inhibitor. RNA sequencing data revealed the adverse effect of PM exerted on the liver is closely associated with ferroptosis. Western blotting assay uncovered the protein level of GPX4, HO-1 and FTL was sharply decreased, while the ROS content was dramatically elevated in L02 cells treated with RPM, which can be partially restored after processing.

Conclusions

The hepatotoxicity induced by RPM was significantly lower than the PMP, and its potential mechanism is associated with ferroptosis.
Mapping malaria vectors and insecticide resistance in a high-endemic district of Haryana, India: implications for vector control strategies
Authors: Kumar Gaurav , Gupta Sanjeev , Kaur Jaspreet , Pasi Shweta , Baharia Rajendra , Mohanty Ajeet Kumar , Goel Pawan , Sharma Amit , Rahi Manju
Published: April 2024

Background

Achieving effective control and elimination of malaria in endemic regions necessitates a comprehensive understanding of local mosquito species responsible for malaria transmission and their susceptibility to insecticides.

Methods

The study was conducted in the highly malaria prone Ujina Primary Health Center of Nuh (Mewat) district of Haryana state of India. Monthly entomological surveys were carried out for adult mosquito collections via indoor resting collections, light trap collections, and pyrethrum spray collections. Larvae were also collected from different breeding sites prevalent in the region. Insecticide resistance bioassay, vector incrimination, blood meal analysis was done with the collected vector mosquitoes.

Results

A total of 34,974 adult Anopheles mosquitoes were caught during the survey period, out of which Anopheles subpictus was predominant (54.7%). Among vectors, Anopheles stephensi was predominant (15.5%) followed by Anopheles culicifacies (10.1%). The Human Blood Index (HBI) in the case of An. culicifacies and An. stephensi was 6.66 and 9.09, respectively. Vector incrimination results revealed Plasmodium vivax positivity rate of 1.6% for An. culicifacies. Both the vector species were found resistant to DDT, malathion and deltamethrin.

Conclusion

The emergence of insecticide resistance in both vector species, compromises the effectiveness of commonly used public health insecticides. Consequently, the implementation of robust insecticide resistance management strategies becomes imperative. To effectively tackle the malaria transmission, a significant shift in vector control strategies is warranted, with careful consideration and adaptation to address specific challenges encountered in malaria elimination efforts.