bluuebunny/crossref_metadata_2025 huggingface dataset:
Activation of the α2A adrenoceptor in microglia promotes LPS-induced TNF-α production and cognitive impairment in mice
Authors: Fang Ming , Song Wen-Liang , Dai Xiao-Meng , Wang Rui-Jie , Xu Hui , Yang Duo-Meng , Tang Xiang-Xu , Xing Yun , Xu Ya-qian , Zhou Li-bing , Zeng Hong-Ke , Wang Huadong
Published: February 2020

Background: a2A adrenoceptor receptor (a2A-AR) plays an important role in inflammatory response in Kupffer cells in sepsis. Blockage of a2A-AR inhibits lipopolysaccharide (LPS)-induced tumor necrosis factor a (TNF-a) production and protects the target organ functions in sepsis animal models; however, its expression and function in microglia have remained obscure. This study aimed to determine whether a2A-AR was expressed in microglia and whether its activation would exacerbate microglial inflammation and sepsis-related neurological dysfunction. Methods: Western blotting and immunofluorescence were used to detect a2A-AR expression in BV-2 microglia. Enzyme-linked immunosorbent assay (ELISA) was used to assess the TNF-a production in the supernatant after LPS induced BV-2 cells were pretreated with a2A-AR agonist BHT933, and/or a2A-AR antagonist BRL44408, and also in the supernatants derived from BV-2 cells treated with BHT933 and/or PKC inhibitor. Signaling pathways including JNK，P38，ERK，IκBa, CREB and PCK were detected by western blotting. a2A-AR gene knock-out (KO) and wild type (WT) mice were prepared by intraperitoneal injection of LPS. Lectin /TNF-a labeled microglia and synaptophysin/NeuN expression in the hippocampus were localized by immunofluorescence. Morris water maze test, Rotating-stick test, Elevated plus maze test and Open-field test were conducted over 4 weeks.Results: a2A-AR was constitutively expressed in BV-2 microglia, which was enhanced by LPS. Pretreatment with BHT933 promoted LPS-induced IκB and JNK phosphorylation, and TNF-a secretion in BV-2 microglia which were abrogated by BRL44408. Activation of a2A-AR by BHT933 also increased PKC phosphorylation in LPS-treated BV-2 microglia. PKC inhibitor significantly reversed the promoting effects of BHT933 on IκB and JNK phosphorylation as well as TNF-a secretion in LPS-treated BV-2 microglia. Furthermore, LPS treatment significantly increased hippocampal microglia activation and TNF-a expression, decreased hippocampal synaptophysin expression, and impaired cognitive and motor functions in WT mice, all of which were markedly reversed by a2A-AR gene knockout. Conclusion: a2A-AR activation promotes LPS-induced IκB and JNK phosphorylation as well as TNF-a production in microglia through the PKC signaling pathway. Knockout of a2A-AR gene significantly improves LPS-induced cognitive and motor impairments in mice, indicating that a2A-AR is a potential therapeutic target for sepsis-associated encephalopathy.
Activation of SIRT1 by Hyperbaric Oxygenation Promotes Recovery of Motor Dysfunction in Spinal Cord Injury Rats
Authors: Chen Huiqiang , Yao Mengyu , Li Zhibo , Xing Ranran , Zhang Cheng , Dai Yong , Yin Xinwei , Tang Jiewen , Huang Huai
Published: February 2020

Background: Emerging evidence demonstrated that hyperbaric oxygenation (HBO) therapy improved the locomotor dysfunction following spinal cord injury (SCI). Sirtuin1(SIRT1) has been characterized as neuroprotection in nerve system. However, whether SIRT1 is involved in alleviation of locomotor function by HBO therapy is unclear. Methods: The Basso, Beattie Bresnahan (BBB) locomotor rating scale was used to evaluate the open-field locomotor function. Western blot, real-time quantitative reverse transcription polymerase chain reaction, SIRT1 activity assay and enzyme-linked immunosorbent assays were performed to explore the molecular mechanisms in adult Sprague-Dawley rats. Results: We found that series HBO therapy significantly improved the locomotor dysfunction and ameliorated the decrease mRNA, protein and activity of spinal cord SIRT1 induced by traumatic SCI injury in rats. In addition, intraperitoneal injection SIRT1 antagonist EX-527 abolished the beneficial effects of series HBO treatment on locomotor deficits and SIRT1 activity loss caused by traumatic SCI injury. However, the rats undergone both series HBO therapy and SIRT1 agonist SRT1720 got the higher BBB score than that undergone series HBO treatment only. Importantly, series HBO treatment following the traumatic SCI injury inhibited the inflammatory cascade and apoptosis-related protein, which was retained by EX-527 and enhanced by SRT1720. Furthermore, EX-527 blocked the enhanced induction of autophagy series with HBO application. Conclusion: These findings demonstrated a new mechanism for series HBO therapy involving activation of SIRT1 and subsequent modulation of inflammatory cascade, apoptosis and autophagy, which contributed to the recovery of motor dysfunction. Key words: HBO, SIRT1, motor dysfunction, inflammation, autophagy, apoptosis
Efficient anchoring of Erianthus arundinaceus chromatin introgressed into sugarcane by specific molecular markers
Authors: Huang Yongji , Wu Jiayun , Li Xueting , Yu Fan , Hu Xuguang , Luo Ling , Zhang Muqing , Xu Liangnian , Deng Zuhu
Published: February 2020

Erianthus arundinaceus is a valuable gene reservoir for sugarcane improvement. However, insufficient molecular markers for high-accuracy identification and tracking of the introgression status of E. arundinaceus chromatin impede sugarcane breeding. Fortunately, suppression subtractive hybridization (SSH) technology provides an excellent opportunity for development of high-throughput E. arundinaceus-specific molecular markers at a reasonable cost. In this study, we constructed a SSH library of E. arundinaceus. In total, 288 clones E. arundinaceus-specific repetitive sequences were screened out and their distribution patterns on chromosomes were characterized by fluorescence in situ hybridization (FISH). A subtelomeric repetitive sequence Ea086 and a diffusive repetitive sequence Ea009, plus 45S rDNA-bearing E. arundinaceus chromosome repetitive sequence EaITS were developed as E. arundinaceus-specific molecular markers, namely Ea086-128, Ea009-257, and EaITS-278, covering all the E. arundinaceus chromosomes for high-accuracy identification of putative progeny. Both Ea086-128 and Ea009-257 were successfully applied to identify the authenticity of F1, BC1, BC2, BC3, and BC4 progeny between sugarcane and E. arundinaceus. In addition, EaITS-278 was a 45S rDNA-bearing E. arundinaceus chromosome-specific molecular marker for rapid tracking the inherited status of this chromosome in sugarcane background. Three BC3 progeny had apparently lost the 45S rDNA-bearing E. arundinaceus chromosome. We reported herein a highly effective and reliable SSH-based technology for discovery of high-throughput E. arundinaceus-specific sequences bearing high potential as molecular markers. Given its reliability and savings in time and efforts, the method is also suitable for development of species-specific molecular markers for other important wild relatives to accelerate introgression of wild relatives into sugarcane.
Annexin A2 Promotes Development of Retinal Neovascularization through PI3K/ AKT Pathway
Authors: Li Chen-yue , Zhao Zi-chang , Zhao Shi-hong
Published: February 2020

Background RNV is a pathological characteristic of PDR and ANXA2 play an important role in the process of RNV while the mechanism remains unclear. We explore the role and molecular basis of ANXA2 in the formation of RNV and seek for new potential targets for the prevention and treatment of PDR. Methods Lentivirus containing plasmids which can interfere ANXA2 and overexpress ANXA2 were packaged and infected HRECs, dividing HRECs into 4 groups. Moreover, 1ul SC79 solution was added in shA2 group and 1ul LY294002 solution was added into lentiA2 group. Western Blot was used to detect expression of ANXA2 and changes in phosphorylation degree of major proteins in PI3K/AKT signaling pathway in each group of HRECs. HRECs of all groups were used to perform EDu cell proliferation assay, Transwell cell migration assay and Matrix tube formation assay. C57BL/6J mice were randomly divided into 3 groups. Mice of OIR group were injected intraperitoneally with 0.05ml PBS every day from 7th to 10th day while mice of LY294002 treatment group were injected with 0.05ml LY294002 solution and no treatment in the control group. Lectin GS-IB4 fluorescence staining was used to observe RNV in mice in all groups. The expression of ANXA2 in mouse retinas was detected by Westen-blot. Results The proliferation, immigration and angiogenesis ability of HRECs is lower in shA2 group than shNC and SC79 treatment group while higher in lentiA2 group than lenti-EGFP and LY294002 treatment group. ANXA2 expression is significantly higher in retina of mice in OIR group and LY294002 treatment group. RNV is significantly less severe in LY294002 treatment group than that in OIR group. Conclusions ANXA2 can promote development of RNV through PI3K/ AKT Pathway.
Improving Evaluation of Potato Resistance to Rhizoctonia solani infection by Optimizing Inoculum Method Combined with Toxin-based Assay
Authors: Zhang Xiaoyu , Xing Xing , Feng Yayan , Yu Zhuo , Hao Jianjun , Li Dezhou
Published: February 2020

Background: Rhizoctonia solani causes stem canker and significantly impacts the production of potato. Conventional assay to evaluate potato resistance using R. solani inoculum is time consuming. To establish an effective and fast assay, 20 potato germplasms were examined using both R. solani inoculum and R. solani-derived toxin (RS toxin). Results: In field trials of 2009 and 2010, wheat-bran-based inoculum of R. solani was incorporated at either 0, 2, 3, 4 or 5 g per seed piece in the soil followed by sowing potato seed pieces in the furrow. Stem canker was evaluated in the growing season. Inoculum of wheat-bran-based 2, 3, or 4 g could well distinguish resistance of potato germplasms. For a quick assay of resistance screening, a toxin-based method was established by treating potato seedlings with the toxin of R. solani (RS toxin). RS toxin was prepared by heating R. solani culture. Potato seedlings were obtained through tissue culture and grown in Murashige and Skoog medium. Seedlings at the stage of 12 cm in height were transferred into agar medium amended with RS toxin and incubated for eight days. The inhibition caused by RS toxin was positively correlated with toxin concentration. By evaluating various potato cultivars that have different sensitivities to toxin, the inhibition of potato stems sections and seedlings was from 33% to 100% and from 32% to 148%, respectively. Results of toxin-based evaluation were highly correlated with the field data using pathogen inoculum (r = 0.731, P < 0.01). Conclusions: Inoculation with wheat bran-mediated R. solani of 2, 3 or 4 g per seed piece was an effective method for the evaluation of potato resistance in field trials. The toxin-based assay could improve efficiency and speed of disease resistance evaluation of potato germplasms. Both assays showed that none of the 20 potato materials was completely resistant to R. solani. However, cultivar ‘Desiree’ had the lowest level of disease, whereas ‘Atlantic’, ‘Favorita’, and ‘Shepody’ showed the high susceptibility.
Body mass index in relation to prostate specific antigen-related parameters
Authors: Lin Dandan , Liu Ting , Chen Luling , Chen Zongtao
Published: February 2020

Purpose Limit previous studies were conducted to assess the association between body mass index (BMI) and series of prostate-specific antigen (PSA)-related parameters, which taken prostate volume (PV) and blood volume (BV) into consideration. The objective of this study was to assess the relationship between BMI and parameters of PSA concentrations in Chinese men. Methods A total of 86,930 men who had undergone annual medical examinations at the First Affiliated Hospital of Army Medical University between 1 January 2011 and 31 December 2018 were included. Partial Spearman correlation rank test was used to assess the relationship between BMI, PV, BV and PSA, and then estimated the correlation between BMI and series of PSA-related parameters. Results After adjustment for age, PV (correlation coefficient = 0.227, P-value < 0.001) was positively associated with PSA levels, but BMI (correlation coefficient = -0.057, P-value < 0.001) and BV (correlation coefficient = -0.041, P-value < 0.001) inversely correlated to PSA concentrations. Moreover, present study also indicated that BMI positively associated with PV and BV. Furthermore, present study identified that PSA mass (correlation coefficient = 0.001, P-value = 0.763) was not affected by obesity after adjustment for age in Chinese general men.Conclusion The results of this large-sample, hospital-based study in China indicated that a higher BMI might have a bigger PV and larger BV. BMI was negatively associated with PSA and PAS density, and no significantly association was detect between BMI and PSA mass.
Low expression of plakoglobin in intratumoral liver tissue is associated with poor survival after curative resection of Hepatocellular Carcinoma
Authors: Ma De-Ning , Liu Zhuo , Yuan Jie , Gao Xin-Yi , Sun Dian-Dian , Fu Zhi-Xuan
Published: February 2020

Background: Plakoglobin also known as γ-catenin, is a member of the Armadillo family. It’s a structural and functional homologue of protein β-catenin with dual functions in cell-cell adhesion and cell signaling. However, the role of plakoglobin in hepatocellular carcinoma (HCC) is unclear to date. Our aim was to investigate the expression of plakoglobin in HCC and its correlation with prognosis and then to further study the underlying function.Methods: Western Blot and qRT-PCR were used to examine the expression of plakoglobin in HCC cell lines and normal hepatocyte cell line. Immunohistochemical method was used to analyze the expression and relationship of plakoglobin in tissue microarray with 191 HCC patients through Kaplan-Meier analysis.Results: Patients with high expression of plakoglobin had a better survival compared with those with low expression (OS, P=0.002; DFS, P=0.012). Plakoglobin is an independent prognostic factor for patients (OS, P=0.026, DFS, P=0.045). Plakoglobin was inversely consistent with the metastatic potential ability of HCC cell lines.Conclusions: Our founding indicates plakoglobin is an independent prognostic marker of HCC, and patients with low expression of that had a poor survival. Plakoglobin may serve as a potential target for anti-HCC.
Recruitment, experience, and retention among women with HIV and hazardous drinking enrolled in the WHAT-IF? Study
Authors: Canidate Shantrel , Cook Christa , Varma Deepthi , Carnaby Giselle , Ennis Nicole , Stetten Nichole , Cook Robert
Published: February 2020

Background: Despite efforts by the NIH to enhance the participation of women and minorities in clinical research, women with or without HIV continue to remain underrepresented. The purpose of this study is to better understand the reasons why women with HIV and hazardous drinking participated in the WHAT-IF? Study and to discuss their experience (positive or negative) in the study. Methods: Convenience and theoretical sampling were used to recruit women with HIV and hazardous drinking to complete qualitative interviews. These women had previously completed a clinical alcohol intervention trial and had consented to be contacted in the future for study-related purposes. The biopsychosocial model was used to frame the interview questions that assessed multiple determinants of drinking behavior and helped explain linkages to broader health constructs. Results: A total of 20 women with HIV and hazardous drinking completed the qualitative interview. Several factors were identified by the women as influential in their decision to participate in the WHAT-IF? study, such as the ability to quit or reduce their drinking to nonhazardous levels (biological), the ability to gain knowledge or a greater understanding of the negative effects of hazardous drinking on HIV disease progression (psychological), and peer pressure and monetary compensation (social). Also, the women identified factors (positive or negative) associated with their clinical trial experience, such as the effects of the study medication on the woman's body (biological), thoughts and feelings toward study procedures (i.e. medication, lab work, study assessments) and the length of the study (psychological), and the interactions with the WHAT-IF? Study staff (social). Conclusion: Recruiting and retaining women with or without HIV in clinical research remains a challenge. Findings from this study suggest that women with HIV who are hazardous drinkers may benefit from participating in research studies that could help them to reduce or quit their drinking, increase their knowledge about specific behavior changes, and earn monetary compensation. Also, positive staff interactions may be instrumental in retaining minority women in clinical research.
Does Health Literacy Affect the Uptake of Annual Physical Check-Up?: The Varying Impact by Age Groups
Authors: Lee Hee Yun , Kim Sooyoung , Neese Jessica , Lee Mi Hwa
Published: February 2020

Introduction Little is known about how health literacy is linked to physical check-ups. This study aimed to examine the levels of physical check-ups by age group and the role of health literacy regarding physical check-ups. Methods Data for the study were obtained from the 2017 Health Information National Trends Survey. The original sample included 3,285 respondents, but only 3,146 surveys were used for this study. Andersen’s Behavioral Model of Health Services Use (Andersen, 1995) guided this study, and a binomial logistic regression model was conducted using Stata 12.0 software package. Results Annual check-ups were reported by 82.0% of the older group and 67.3% of the younger group. Both groups had similar ratios for health literacy-related item reporting. Study results show that annual check-up was positively associated with confidence in getting health information, having health insurance, and having a primary doctor for both age groups. However, getting a regular check-up was negatively associated with frustration while searching for information among the younger group while it was positively associated with difficulty understanding information for the older group. Conclusions To increase annual physical check-ups, health literacy-related interventions should be developed and address the barriers most associated with health check-ups. One way of addressing this barrier is to improve the line of communication from healthcare professionals to consumers through the use of easy-to-understand explanations appropriate for the consumer.
Kinetics and Specificity of HEK293T Extracellular Vesicle Uptake using Imaging Flow Cytometry
Authors: Jurgielewicz Brian , Yao Yao , Stice Steven L.
Published: February 2020

Background : Extracellular vesicles (EVs) are nanosized vesicles naturally secreted from cells responsible for intercellular communication and delivery of proteins, lipids, and other genetic material. Ultimately, EVs could provide innate therapeutic contents and loaded therapeutic payloads such as small molecules and gene therapy vectors to recipient cells. However, comparative kinetic measures that can be used to quantify and ultimately optimize delivery and uptake of EV payloads are lacking. We investigated both dose and time effects on EV uptake and evaluated the potential specificity of EV uptake to better understand the kinetics and uptake of human embryonic kidney (HEK293T) derived EVs. Results : Utilizing an imaging flow cytometry platform (IFC), HEK293T EV uptake was analyzed. HEK293T EV uptake was dose and time dependent with a minimum threshold dose of 6,000 EVs per cell at 4 hours of co-culture. HEK293T EV uptake was inhibited when co-cultured with recipient cells at 4°C or with pre-fixed recipient cells. By co-culturing HEK293T EVs with cell lines from various germ layers, HEK293T EVs were taken up at higher quantities by HEK293T cells. Lastly, human neural stem cells (hNSCs) internalized significantly more HEK293T EVs relative to mature neurons. Conclusions : Imaging flow cytometry is a quantitative, high throughput, and versatile platform to quantify the kinetics of EV uptake. Utilizing this platform, dose and time variables have been implicated to affect EV uptake measurements making standardization of in vitro and in vivo assays vital for the translation of EVs into the clinic. In this study, we quantified the selectivity of EV uptake between a variety of cell types in vitro and found that EVs were internalized at higher quantities by cells of the same origin. The characterization of HEK293T EV uptake in vitro, notably specificity, dose response, and kinetic assays should be used to help inform and develop EV based therapeutics.
Kinect Based System and Serious Game Motivating Approach for Physiotherapy Assessment and Remote Session Monitoring
Authors: Cary Francisco , Postolache Octavian , Gira˜o Pedro Silva
Published: February 2020

This paper describes a framework focused on being a health monitoring platform as well as a source of entertainment for physiotherapy patients, particularly stroke survivors. Using the Microsoft Kinect sensor a serious game captures 3D data during the patient’s session and sends it to a server. Through a web application these data can be further visualized by the physiotherapists on their assessments. Moreover, this framework intends to be a useful and effective tool for remote physiotherapy sessions allowing for a considerable cost reduction. Experimental results related to arms and shoulders rehabilitation are included in this paper.
Sleep in relation to psychiatric symptoms and perceived stress in Swedish adolescents aged 15 to 19 years
Authors: Thorsén Frida , Antonson Carl , Sundquist Jan , Sundquist Kristina
Published: February 2020

Background:

Sleep affects psychiatric health and perceived stress during adolescence.

Objective:

The first aim of this study was to investigate the prevalence of poor sleep in a sample of Swedish adolescents aged 15 to 19 years. The second aim was to investigate correlations between: a) sleep and psychiatric symptoms and; b) sleep and perceived stress. The third aim was to examine possible sex differences in sleep.

Method:

In 2011, a total of 185 Swedish adolescents (aged 15 to 19 years) from two upper secondary schools participated in this cross-sectional study. We used three different psychometric scales: Pittsburgh Sleep Quality Index (PSQI), Symptoms Checklist (SCL-90), and Perceived Stress Scale (PSS) to measure sleep, general psychiatric health and perceived stress.

Results:

In total, 76% of the female students and 71% of the male students had poor overall sleep quality. A large majority, 93%, reported daytime dysfunction and 60% reported problems staying awake during daily activities. The correlation between sleep and general psychiatric health was 0.44 and the correlation between sleep quality and perceived stress was 0.48. Female students reported significantly more sleep disturbances than male students do.

Conclusions:

Three out of four of the upper secondary school students presented with poor overall sleep that associated with psychiatric symptoms and perceived stress. These findings add to results from earlier studies and imply that interventions to improve sleep in adolescents, individually as well as on a societal level, should be considered as one way of trying to impact the observed rising numbers of psychiatric complaints. Such interventions may improve mental and somatic health in adolescents and prevent the development of psychiatric and stress-related symptoms. Further studies of possible methods, and their implementation, for improving sleep in adolescents should be of high priority.
Mitigating chilling stress of pepper plant (Capsicum annuum L.) using Dimethyl Ether combustion gas in controlled greenhouse
Authors: Basak Jayanta Kumar , Qasim Waqas , Okyere Frank Gyan , Khan Fawad , Lee Yong Jin , Park Jihoon , Kim Hyeon Tae
Published: February 2020

In this study, the possibility of enhancing chilling stress tolerance of pepper plant (Capsicum annuum Linnaeus) during early growth stages was investigated using DME combustion gas in controlled greenhouse. The experiment was conducted to determine the performance of DME combustion gas when used as a fuel for DME burner for raising temperature and CO2 concentration in greenhouse and also to examine its effects on morphology parameters of hot pepper in winter season. To analyze the relationship between the application of DME and morphology parameters of pepper plant, three treatments (DME-1, DME-2 and DME-3) for three controlled greenhouses were assayed. DME-1 and DME-2 treatments consisted of average DME flow quantity in duct were 17.4 m3/min and 10.2 m3/min, respectively to greenhouse-1 and greenhouse-2 and no DME gas was supplied to greenhouse-3 which was left as control (DME-3). Morphology parameters such as plant height, leaf area and leaf area index (LAI), net assimilation rate (NAR), relative growth rate (RGR), fresh weight and dry weight were measured for eight weeks for each treatment and analyzed using completely randomized designs through analysis of variance with a significance level of P < 0.05. Although DME-1, DME-2 and DME-3 received same crop management practices and controlled environmental factors, the highest changes (p < 0.05) of plant height, leaf area, LAI and fresh weight were found from the DME-1 treatment, followed by DME-2. A comparison of relative growth rates among the treatments indicated more rapid relative growth rate of morphology parameters at vegetative phase of plant implying better yield. Therefore endorsed quantify of DME combustion gas for a specified crop can be applied to greenhouse to improve the plant growth and enhance yield with mitigating chilling stress in winter season.
Prácticas familiares a distancia en contextos de migración internacional materna y/o paterna
Authors: Zapata Martínez Adriana
Published: February 2020

A partir de los procesos de migración internacional, las prácticas familiares no están supeditadas a un espacio y tiempo específico, pues sus miembros se encuentran ubicados en dos o más países, por lo que se generan nuevas configuraciones familiares que provocan cambios y ajustes a partir del distanciamiento físico. El objetivo de este artículo es identificar y comprender las prácticas familiares que permiten mantener las relaciones y los vínculos parento-filiales desde la distancia, a partir de la migración internacional de madres y/o padres colombianos a Santiago de Chile. Estas reflexiones se dan en el marco de una metodología cualitativa, en la que se utilizaron técnicas como la entrevista en profundidad, el plano de vida familiar y la cartografía familiar, las cuales fueron utilizadas con padres/madres inmigrantes y sus hijos/hijas residentes en Colombia. De acuerdo con los resultados obtenidos en campo, existen tres tipos de prácticas familiares (prácticas continuas, prácticas discontinuas y prácticas creativas), las cuales involucran acciones regulares como rutinas, celebraciones y tradiciones familiares, que son mantenidas y/o recreadas a través de la memoria, los medios materiales, tecnológicos y comunicativos.
Adolescentes en Internet: la mediación entre riesgos y oportunidades
Authors: Osorio Tamayo Dora Liliana , Millán Otero Katy Luz
Published: February 2020

Se presenta una investigación realizada con el objetivo de describir los significados asociados a situaciones problemáticas y riesgos, oportunidades y mediaciones en el uso de Internet, identificadas por adolescentes, padres/madres y profesorado de instituciones educativas de la ciudad de Medellín, Colombia. El método se basó en un diseño cualitativo, concertado con el equipo  de Kids online Latinoamérica (Latamko). Los resultados resaltan las tensiones entre los significados de oportunidad y riesgo en el uso de la Internet, de manera que se interrogó la mediación de padres y docentes, haciendo visibles límites en el aprovechamiento de las TIC atribuidos a la heterogeneidad y la brecha digital entre adultos y jóvenes. Como conclusión, se comenta la percepción de insuficiencia que tienen los jóvenes frente a la actuación de  padres/madres y docentes, quienes se debaten entre prevenir e incentivar la apropiación de las herramientas para el aprendizaje.
DIAMANTI, I., y LAZAR, M. (2019): Peuplecratie. La métamorphose de nos démocraties. París: Gallimard.
Authors: Urteaga Eguzki
Published: February 2020

Ilvo Diamanti y Marc Lazar acaban de publicar el libro titulado Peuplecratie. La métamorphose de nos démocraties (Pueblocracia. La metamorfosis de nuestras democracias) en la editorial Gallimard.
La Educación sentimental en el pensamiento de Julián Marías. Una reflexión en el contexto colombiano
Authors: Lázaro Quintero Manuel Andrés
Published: February 2020

La educación sentimental es uno de los núcleos importantes de reflexión del pensamiento del filósofo español Julián Marías Aguilera y corresponde a una visión antropológica personalista. La educación sentimental es el núcleo donde se encuentra la raíz de todos los demás aspectos vitales. Este artículo pretende analizar la visión antropológica de la filosofía de Julián Marías, específicamente en la obra La educación sentimental, y pensar a la persona como una criatura amorosa. Volver sobre los sentimientos en la persona contribuirá a rescatar una de las dimensiones más olvidadas y desplazadas por la cultura intelectual, de tal manera que esta investigación destaca el valor de una antropología filosófica que, al haber sido pensada y expresada en español, tiene unas posibilidades humanas que no han sido desarrolladas por otras lenguas en las que se ha hecho filosofía hasta el siglo XX, con posibilidades de aplicación en el posconflicto colombiano.
Drug- and toxin-induced pulmonary arterial hypertension: Current state of the literature
Authors: Ramirez III Ramon L , Thomas Christopher A , Anderson Ryan J , Bernardo Roberto J , Al-Motarreb Ahmed , Al-Suwaidi Jassim , Zamanian Roham T , De Jesus Perez Vinicio A
Published: February 2020

Drug- and toxin-induced pulmonary arterial hypertension (PAH) is an increasingly important sub-group of group 1 pulmonary hypertension (PH). In the last 60 years, we have seen the rise and fall of numerous prescription and illicit agents that have caused severe and deadly outbreaks of PAH. Currently, drugs and toxins are classified into “possible” and “definite” risk factors for PAH. While the exact mechanisms and pathogenesis of drug- and toxin-induced PAH are currently unknown, novel clinical and basic science studies are beginning to unravel the biologic factors and genetic underpinnings responsible for disease development. The clinical management of affected patients can be challenging as it is often difficult to identify patients early and demonstrate causality between drugs and PAH. Given the recent trends in drug utilization and development, it is highly likely that we will continue to identify new agents capable of causing pulmonary vascular disease. We must keep a high index of suspicion in order to identify patients and new compounds deemed definite or likely risk factors for PAH. Practicing pharmacovigilance, raising awareness, and working in tandem with PH patient associations and drug regulatory agencies may ultimately be our most effective strategy in preventing the next deadly outbreak of drug- and toxin-induced PAH.
Dynamic performance analysis for wind turbine in complex conditions
Authors: Cao Li , Sun Wenlei , Zhou Jianxing , Cui Quanwei
Published: February 2020

The effect of dynamic performance shall be considered when calculating the wind speed relative to the wind turbine structure, since it is essential to prolong its service life. This article presents a method to get dynamic responses of a wind turbine under different conditions. The time-varying load acting on the blade is calculated by using the blade element momentum theory, and the dynamic performance of the wind turbine are calculated by applying the modal superposition method with blade loads as excitations. A platform is constructed to experimentally test the dynamic responses of the wind turbine system. The dynamic response process is adopted to carry out a dynamic analysis, and theoretical results are compared with experimental results, indicated that the analysis presented in this paper is correct. In addition, the 2 MW wind turbine operating in different wind fields is analyzed by applying the computing method. The results indicate that the wind turbine experiences a huge transverse vibration under turbulent wind, the hub vibration is intensified up to 179.52 %, and the vibration of the blade tip intensifies up to 190.41 % under the action of gusts in extreme conditions relative to the steady state, which shall be considered during design.
Seismic performance analysis of steel beam to CFST column connection with ductility and energy dissipation components
Authors: Wang Jingxuan , Li Qiuying , Wei Guoqiang
Published: February 2020

Concrete-filled steel tubular (CFST) column to steel beam joint with the ductility and energy dissipation components is a type of connection which is used in prefabricated structures, to improve the capacity of connections and construction efficiency. In this paper, two different type of steel beam to CFST column connections with the penetrated high-strength bolts and end-plate are investigated, i.e., steel beam to CFST column connection with end plate (CJ-1), and T-stub bolted (CJ-2) connections. The finite element model (FEM) of steel beam to CFST column connection with the penetrated high-strength bolts under cyclic loading are conducted based on the whole process of the nonlinear explicit analysis method using ABAQUS. The feasibility of FEM is verified by a set of experimental results performed by our research group, as well as available test results from other researchers. The failure modes, bearing capacity, energy dissipation capacity and ductility and rigidity degeneration were studied. As a result, the load-displacement hysteretic loop curve of CJ-2 connection is plump. However, the hysteresis curve of CJ-1 shows pinching phenomenon. The value of buckling load and ultimate load of CJ-2 increased by 28 % and 30 % respectively, compared with CJ-1. With respect of stress analysis, the plastic strain accumulation position distribution is relatively uniform duo to the T-stub connection, avoiding the penetrated high-strength bolt early yield or fracture. The results show that the steel beam to CFST column connection with penetrated bolts and T-stub connection has good seismic capacity.
Double-Slot Optical Ring Resonator Sensor
Authors: ÇİÇEK Kenan
Published: February 2020

Optical micro-ring resonator (MRR) sensors are an emerging technology that attracts attention not only because it’s small footprint but also because of its high-quality features. In this work, a Silicon on Insulator (SOI)-based MRR sensor is studied for a practical label-free sensor. After the analysis of this study, it is found that a smaller (compare to previous studies) label-free optical sensor with a sensitivity of 206nm/RIU and a q-factor of 17900 can be obtained when the optimal designed parameters are used. Thus, it is believed that, this work would shed a light on optical sensor technology for more compact-efficient, low-cost and complementary metal-oxide-semiconductor (CMOS)-compatible sensors for daily life usage.
Withdrawal Notice: Impact of One-rod Levonorgestrel Implant on Blood Chemistry Profile: A Cohort Study
Authors: Gunardi Eka Rusdianto , Surya Raymond
Published: February 2020

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"Withdrawn" from the journal. Withdrawal means that the article files are removed and replaced with a PDF stating that the
article has been withdrawn from the journal in accordance with BSP Editorial Policies.
Factors Affecting the Age at Menarche in High School Students in the West of Iran
Authors: Faraji-Goodarzi Mojgan , Taee Nadereh , Mohsenifar Khadijeh
Published: February 2020

Background:

.The age at menarche is a chief determinant of female puberty, which also
indicates the health of the target population that is influenced by various environmental and hereditary
factors.

Objective:

This study aims to evaluate the factors that impact the age at menarche in high school
students of Khorramabad.

Methods:

This study is a cross-sectional correlational study that included 544 students attending
high school in Khorramabad. The following information was collected: demographic data, age at
menarche and anthropometric characteristics.

Results:

The mean age at menarche subjects was 13.10±1.06 years and menarche age ranges from
10 to 16 years. There was no significant difference in the demographic data and age at menarche.
The height of students was the significant determinant of the age at menarche; whereas, students’
weight showed had an inverse relationship. Consequently, the body mass index (BMI) of students
had a significant difference with the age at menarche.

Conclusion:

The age of menarche was positively associated with growth in height and inversely
associated with weight and BMI.
Mitigation of Harmonics from Output of Cascaded H Bridge Multilevel Inverter Using SHE PWM and AI Technique: A Review
Authors: Bhatt Kaushal , Chakravorty Sandeep
Published: February 2020

An extensive use of fossil fuel has led to an extreme increment of carbon footprint in the world globally. Glaciers are melting on the earth’s poles due to the greenhouse effect. Many such natural indications urge us to adopt renewable energy sources. In most cases, renewable power is generated in electrical form, which does not suit the existing grid requirements. Cascaded H bridge with multilevel inverter topology is promising in this context. The output of the multilevel inverter is near to sinusoidal. It has added advantages of low device stress, no need for step-up transformers, low common-mode voltage, near sinusoidal input current, low switching frequency, and reduced harmonics. The direct output of Cascaded H bridge multilevel inverters may not be suitable for many applications like integrating solar panel output with an existing grid where harmonic reduction is necessary. Various modulation techniques are available like sinusoidal pulse width modulation, space vector modulation, and selective harmonic elimination. Among the listed modulation techniques, selective harmonic elimination can be implemented with the low switching frequency, and it is suitable where low electromagnetic interference, low switching loss, and good power quality are required. To reduce the harmonics, one must solve the non-linear transcendental output equations of the cascaded H-bridge Multilevel inverter (CHB-MLI). Various Artificial Intelligent (AI) algorithms are introduced, and researchers have worked on eliminating harmonics or minimizing Total Harmonics Distortion (THD) from the output of CHB-MLI. This paper gives a review of the harmonic reduction using some of the well-known explored AI algorithms. It also provides insight into some of the unexplored algorithms in this area.
Penguatan wawasan kebangsaan generasi muda melalui kegiatan tadarus buku
Authors: Bahri Hendra Saeful , Sapriya Sapriya , Halimi Muhammad
Published: February 2020

Saat ini penguatan wawasan kebangsaan masih terpusat di persekolahan melalui pembelajaran Pendidikan Kewarganegaraan. Namun sebenarnya penguatan wawasan kebangsaan bagi generasi muda bisa melalui komunitas, salah satunya yaitu komunitas Asian African Reading Club dengan kegiatan utamanya yaitu tadarus buku. Penelitian ini bertujuan untuk menggali dan menganalisis kegiatan tadarus buku dalam menguatkan wawasan kebangsaan bagi generasi muda. Pendekatan yang digunakan dalam penelitian ini yaitu kualitatif dengan metode studi kasus. Pengumpulan data melalui teknik wawancara, observasi, studi dokumentasi dan studi literature. Analisis data meliputi reduksi data, penyajian data dan penarikan kesimpulan/verifikasi. Temuan penelitian ini menunjukkan bahwa kegiatan tadarus buku dapat memperkokoh wawasan kebangsaan bagi generasi muda, hal tersebut dikarenakan buku-buku yang dibaca bertemakan kebangsaan dan adanya kekuatan dari narasumber dalam mendiskusikan terkait dengan topik yang sudah dibaca oleh peserta tadarus buku.---------------------------------------------------------------------------------------------------------------------------------------Strengthening the insight into the national generation of the young generation through reading book activities (Tadarus)At present, the strengthening of nationalism is still centered in schooling through the learning of Citizenship Education. But actually strengthening the national insight for the younger generation can be done through the community, one of which is the Asian African Reading Club community with its main activity is book tadarus. This study aims to explore and analyze reading book activities (Tadarus)  in strengthening national insight for the youth.  The approach used in this study is qualitative with a case study method. Data collection through interviews, observation, documentation studies, and literature studies. Data analysis includes data reduction, data presentation, and conclusion/verification. The findings of this study indicate that reading book activities (Tadarus)  can strengthen national insight for the youth because books are read with the theme of nationality and the power of the speakers in discussing related topics that have been read by participants.
Pengembangan e-modul berorientasi KKNI pada perkuliahan Pendidikan Kewarganegaraan Universitas Sriwijaya
Authors: Fatihah Husnul , Waluyati Sri Artati , Camellia Camellia
Published: February 2020

Penelitian ini ini bertujuan untuk mengembangkan e-modul berorientasi KKNI pada perkuliahan pendidikan kewarganegaraan dan dampak potensial e-modul berorientasi KKNI terhadap hasil belajar mahasiswa pada perkuliahan pendidikan kewarganegaraan.  Penelitian pengembangan ini menggunakan model ADDIE. Subjek penelitian yang ditetapkan adalah mahasiswa  ilmu komputer dan jaringan yang mengambil Mata Kuliah Pendidikan Kewarganegaraan pada semester Ganjil 2017-2018. Data dikumpulkan melalui teknik dokumentasi, angket, observasi dan tes. Selanjutnya teknik analisis data yang digunakan ialah analisis data kuantitatif. Selain data hasil studi pendahuluan, data angket yang berkaitan dengan validitas produk juga dianalisis dengan menggunakan analisis deskriptif. Berdasarkan hasil analisis dan pembahasan maka disimpulkan e-modul berorientasi KKNI yang dikembangkan ini valid, praktis dan berefek potensial dalam meningkatkan pemahaman mahasiswa terhadap materi. Terkategorikan valid setelah mendapatkan hasil 92% dari validasi ahli bahasa dan 92% ahli materi. Kemudian dalam tiga kali tahapan uji coba mendapatkan tanggapan yang positif dari para mahasiswa penggunannya. Dan pada uji coba lapangan terdapat N-gain 0,6 dengan kategori sedang dari perbandingan pre tes dan pos tes yang dilakukan.-------------------------------------------------------Development of the KKNI-oriented e-module in the lecturing  on Citizenship Education at Sriwijaya UniversityThis study aims to develop KKNI-oriented e-modules in lectures on citizenship education and the potential impact of KKNI-oriented e-modules on student learning outcomes in lectures on citizenship education. This developmental research uses the ADDIE model. The research subjects were computer science and network students who took Citizenship Education Courses in the Odd Semester 2017-2018. Data were collected through documentation techniques, questionnaires, observations, and tests. Furthermore, the data analysis technique used is quantitative data analysis. In addition to the data from the preliminary study, questionnaire data related to product validity were also analyzed using descriptive analysis. Based on the results of the analysis and discussion, it was concluded that the KKNI-oriented e-module developed was valid, practical and had a potential effect in increasing students' understanding of the material. It is categorized as valid after getting 92% results from linguist validation and 92% material experts. Then in the three stages of the trial, there was a positive response from the students. And in the field trials, there are N-gain 0.6 with a moderate category from the comparison of the pre-test and post-tests conducted.
Pengaruh media sosial dan konsep diri terhadap gaya hidup siswa SMAN 3 Kota Solok
Authors: Karmila Roza , Ananda Azwar , Indrawadi Junaidi
Published: February 2020

Tujuan penelitian ini adalah untuk mendeskripsikan pengaruh penggunaan media sosial dan konsep diri terhadap gaya hidup siswa konsumtif SMA Negeri 3 Kota Solok. Jenis penelitian ini adalah deskriptif kuantitatif, populasi dalam penelitian ini adalah siswa SMA Negeri 3 Kota Solok yang berjumlah 1086 dan sampel penelitian ini berjumlah 181 orang. Teknik pengumpulan data menggunakan kuesioner. Teknik analisis data menggunakan uji dekripsi, uji persyaratan dan pengujian hipotesis, hasil penelitian menggambarkan bahwa media sosial berpengaruh terhadap gaya hidup konsumtif siswa SMA Negeri 3 Kota Solok dengan besaran kontribusi sebesar 14.9%,  ini berarti bahwa media sosial dapat mempengaruhi gaya hidup konsumtif siswa. Konsep Diri berpengaruh terhadap gaya hidup konsumtif. Hal ini menjelaskan bahwa dengan konsep diri yang positif dapat mempengaruhi gaya hidup siswa ke arah yang positif dan begitu juga sebaliknya. Media sosial dan konsep diri secara bersama-sama berpengaruh terhadap gaya hidup konsumtif siswa SMA Negeri 3 Kota Solok. Dengan Membekali siswa dengan ilmu pengetahuan agama dan Pendidikan Karakter, sehingga dapat memberikan pemahaman kepada siswa ke arah perilaku positif.------------------------------------------------------------Effect of social media and self-concept on the lifestyle of students of SMAN 3 Kota SolokThe purpose of this study was to describe the effect of using social media and self-concept on the lifestyle of consumptive students of Solok 3 Senior High School. This type of research is descriptive quantitative, the population in this study were students of Solok City 3 High School, amounting to 1086 and 181 research samples. The technique of collecting data was using a questionnaire. The data analysis techniques were decryption test, requirements test, and hypothesis testing.  The results of the study illustrate that social media has an effect on the consumptive lifestyle of Solok 3 Senior High School students with a contribution of 14.9%, this means that social media can influence the student's consumptive lifestyle. The Self Concept influences the consumptive lifestyle. This explains that a positive self-concept can affect the lifestyle of students in a positive direction and vice versa. Social media and self-concept together influence the consumptive lifestyle of Solok 3 Senior High School students. By equipping students with religious science and character education, so as to provide students with an understanding of positive behavior.