bluuebunny/crossref_metadata_2025 huggingface dataset:
Outpatient Microdose Induction with Transdermal Buprenorphine: A Case Series
Authors: Menard Shannon , Jhawar Archana
Published: July 2022

Transdermal buprenorphine is FDA approved for chronic severe pain but has an increasing amount of data supporting its use to transition patients from full opioid agonists to sublingual buprenorphine via a microdose strategy. The literature has primarily focused on patients with a pain diagnosis or who have been prescribed opioids in inpatient units. This case series reviews the use of transdermal buprenorphine to transition patients from methadone and illicit opioids to sublingual buprenorphine. The authors identified seven patients from an outpatient opiate treatment program who received the transdermal buprenorphine protocol. All patients were prescribed methadone and used illicit heroin prior to and during the transition. Five patients (71.4%) successfully completed the transition to sublingual buprenorphine, with all five patients reporting no or mild withdrawal symptoms. These findings suggest that transdermal buprenorphine is a potentially safe and effective microdose induction method for patients who use illicit substances in an outpatient setting.
Root Morphological and Physiological Adaptations to Low Phosphate Enhance Phosphorus Efficiency at Melon (Cucumis melo L.) Seedling Stage
Authors: Li Pengli , Weng Jinyang , Rehman Asad , Niu Qingliang
Published: July 2022

The high phosphorus (P) acquisition ability of crops can reduce their dependence on artificial inorganic phosphate (Pi) supplementation under Pi-limited conditions. Melon (Cucumis melo L.) is vulnerable to Pi deficiency. This study was carried out to explore the morphological and physiological responses of melon to low-Pi stress under a hydroponic system. The results show that low-Pi stress significantly disturbed nutrient homeostasis, reduced P content, and resulted in iron accumulation in melon seedlings and brown iron plaque formation on the root surface. A nutrient pool of P and Fe formed on the roots to forage for more Pi under low-Pi conditions. Severe long-term low-Pi stress promoted primary root elongation and inhibited lateral root growth, which increased the longitudinal absorption zone of the roots. The decrease in P content of the roots upregulated the expression of the acid phosphatase (APase) gene and increased APase activity. The high-affinity phosphate transporter (Pht1) genes were also upregulated significantly. These morphological and physiological responses significantly increased Pi uptake rate and P utilization efficiency at the melon seedling stage. These findings will be useful for screening low-Pi-tolerant varieties and sustaining melon production in P-limited environments.
A Case for Buried Culture: From an Unknown Known to a Known Unknown
Authors: Nativ Assaf
Published: July 2022

This paper makes a case for Buried Culture—humanly modified packages of sediments and artifacts. Specifically, it argues that Buried Culture amounts to an a-social, literally posthuman, cultural being. The argument proceeds through three main steps. Firstly, drawing on the prototypical example of landfills, it demonstrates that while ontically solid, Buried Culture is epistemically vacuous. Secondly, placing it between sedimentology and archaeology, a diagnosis is offered: The epistemic vehicles at our disposal either acknowledge Buried Culture’s existence as a proper being or appreciate its cultural qualities, but not both. Thirdly, an aesthetically oriented approach is proposed, adopting the analytical reasoning of the art critic as a means to straddle this gap. To illustrate this, a small-scale case study is presented, concerned with an early 20th-century landfill near Tel Aviv, Israel.
The Impact of Perinatal Loss Nursing Simulation among Undergraduate Students
Authors: Kang Sook Jung , Kim Yoonjung
Published: July 2022

Providing careful and proper care for women experiencing perinatal loss is essential. Nurses and nursing students must be sufficiently prepared to provide adequate care. Caring for women who experienced a perinatal loss requires special education and instruction, but little is provided to nursing students. This study aimed to investigate the impact of simulation education directed toward caring for women with perinatal loss. A single-group pretest posttest study design was adopted. A convenience sample of 77 undergraduate students participated in the study. The nursing students’ nursing anxiety, confidence for clinical decision-making, communication competence, and simulative effectiveness were measured before and after the simulation. In addition, we asked students open-ended questions. No significant differences were noted in variables. However, the rank order of simulation effectiveness and result of open-ended questions had some noteworthy implications. Although there was no significant effect in results, simulation education about the perinatal loss was helpful for nursing students. Nursing students reflected on perinatal loss situation and learned that they should provide empathetical therapeutic communication based on needs of women with perinatal loss. To assure its effectiveness and to include optimal program content, a need exists to measure student reflection before and after the simulation. To fully guide and support women and their families with perinatal loss, providing standardized care is needed and in order to do that, standard for educational program regarding perinatal loss needs to be developed and delivered to nursing students as well as nurses.
The Epidemiology of COVID-19 by Race/Ethnicity in Oklahoma City–County, Oklahoma (12 March 2020–31 May 2021)
Authors: Khadka Kapil , Adesigbin Kunle , Beetch Jessica , Kuhn Katrin , Wendelboe Aaron
Published: July 2022

We aimed to better understand the racially-/ethnically-specific COVID-19-related outcomes, with respect to time, to respond more effectively to emerging variants. Surveillance data from Oklahoma City–County (12 March 2020–31 May 2021) were used to summarize COVID-19 cases, hospitalizations, deaths, and COVID-19 vaccination status by racial/ethnic group and ZIP code. We estimated racially-/ethnically-specific daily hospitalization rates, the proportion of cases hospitalized, and disease odds ratios (OR) adjusting for sex, age, and the presence of at least one comorbidity. Hot spot analysis was performed using normalized values of cases, hospitalizations, and deaths generated from incidence rates per 100,000 population. During the study period, there were 103,030 confirmed cases, 3457 COVID-19-related hospitalizations, and 1500 COVID-19-related deaths. The daily 7-day average hospitalization rate for Hispanics peaked earlier than other groups and reached a maximum (3.0/100,000) in July 2020. The proportion of cases hospitalized by race/ethnicity was 6.09% among non-Hispanic Blacks, 5.48% among non-Hispanic Whites, 3.66% among Hispanics, 3.43% among American Indians, and 2.87% among Asian/Pacific Islanders. COVID-19 hot spots were identified in ZIP codes with minority communities. The Hispanic population experienced the first surge in COVID-19 cases and hospitalizations, while non-Hispanic Blacks ultimately bore the highest burden of COVID-19-related hospitalizations and deaths.
Influence of the Thermal Environment on Occupational Health and Safety in Automotive Industry: A Case Study
Authors: Rînjea Constanța , Chivu Oana Roxana , Darabont Doru-Costin , Feier Anamaria Ioana , Borda Claudia , Gheorghe Marilena , Nitoi Dan Florin
Published: July 2022

Considering thermal environment aspects have a major impact not only on occupational health and safety (OH&S) performance but also on the productivity and satisfaction of the workers, the aim of the case study was to assess the thermal comfort of a group of 33 workers in an automotive industry company, starting with collecting data about the thermal environment from different workplaces, continuing with the analytical determination and interpretation of thermal comfort using the calculation of the Predicted Mean Vote (PMV) and Predicted Percentage of Dissatisfied (PPD) indices, according to provisions of the standard ISO 7730:2005, and comparing the results with the subjective perception of the workers revealed by applying individual questionnaires. The results of the study represent an important input element for establishing the preventive and protective measures for the analysed workplaces in correlation with the measures addressing other specific risks and, also, could serve as a model for extending and applying to other similar workplaces in future studies. Moreover, the mathematical model and the software instrument used for this study case could be used in further similar studies on larger groups of workers and in any industrial domain.
Cerebral Hemodynamics, Right-to-Left Shunt and White Matter Hyperintensities in Patients with Migraine with Aura, Young Stroke Patients and Controls
Authors: Brunelli Nicoletta , Altamura Claudia , Mallio Carlo A. , Lo Vullo Gianguido , Marcosano Marilena , Bach-Pages Marcel , Beomonte Zobel Bruno , Quattrocchi Carlo Cosimo , Vernieri Fabrizio
Published: July 2022

Background: Migraine with aura (MA) patients present an increased risk of cerebrovascular events. However, whether these patients present an increased white matter hyperintensities (WMHs) load compared to the general population is still under debate. Our study aimed to evaluate the relationship between cerebral hemodynamics, right-to-left shunt (RLS) and WMHs in MA patients, young patients with cryptogenic stroke or motor transient ischemic attack (TIA) and controls. Methods: We enrolled 30 MA patients, 20 young (<60 years) patients with cryptogenic stroke/motor TIA, and 10 controls. All the subjects underwent a transcranial Doppler bubble test to detect RLS and cerebral hemodynamics assessed by the breath holding index (BHI) for the middle (MCA) and posterior (PCA) cerebral arteries. Vascular risk factors were collected. The WMHs load on FLAIR MRI sequences was quantitatively assessed. Results: The stroke/TIA patients presented a higher prevalence of RLS (100%) compared with the other groups (p < 0.001). The MA patients presented a higher BHI compared with the other groups in the PCA (p = 0.010) and higher RLS prevalence (60%) than controls (30%) (p < 0.001). The WMHs load did not differ across groups. BHI and RLS were not correlated to the WMHs load in the groups. Conclusions: A preserved or more reactive cerebral hemodynamics and the presence of a RLS are likely not involved in the genesis of WMHs in MA patients. A higher BHI may counteract the risk related to their higher prevalence of RLS. These results need to be confirmed by further studies to be able to effectively identify the protective role of cerebral hemodynamics in the increased RLS frequency in MA patients.
A Meta-Synthesis Study of Person-Centered Care Experience from the Perspective of Nursing Home Residents
Authors: Kim Eun-Young , Chang Sung-Ok
Published: July 2022

Purpose: To systematically review and synthesize the evidence for the experience of person-centered care from the perspective of nursing home residents to understand their views in depth. Methods: The seven steps of Nobit and Hare’s meta-ethnography, a well-known meta-synthesis method, were applied. We used four databases for the literature search (PubMed, Web of Science, EMBASE, and CINAHL). Results: A total of seven studies were included for review. As a result of synthesizing the results, three themes (“promotion of mutual understanding through communication”, “care that acknowledges the independence of residents” and “finding the optimized state”) and six sub-themes were derived. Conclusions: This study has provided an in-depth understanding of person-centered care and will contribute to increasing its practical application.
The Value of Sport: Wellbeing Benefits of Sport Participation during Adolescence
Authors: Wilson Oliver W. A. , Whatman Chris , Walters Simon , Keung Sierra , Enari Dion , Rogers Andy , Millar Sarah-Kate , Ferkins Lesley , Hinckson Erica , Hapeta Jeremy , Sam Michael , Richards Justin
Published: July 2022

Insight into the unique benefits of sport participation above and beyond those associated with participation in other physical activities among adolescents is limited in Aotearoa New Zealand (NZ). The purpose of this study was to examine the association between wellbeing and organised sport participation among adolescents whilst accounting for demographic characteristics and other recreational physical activity. Demographic characteristics (age, gender, ethnicity, deprivation, (dis)ability status), organized sport, recreational physical activity, and wellbeing were assessed in cohorts of NZ adolescents (11–17 years) between 2017 and 2019. After adjusting for demographics, better wellbeing was associated with participation in any recreational physical activity (OR = 2.49, 95%CI = 1.97–3.13), meeting physical activity recommendations (OR = 1.63, 95%CI = 1.47–1.81), and each additional hour of recreational physical activity (OR = 1.03, 95%CI = 1.02–1.04). After adjusting for demographics and overall recreational physical activity participation, better wellbeing was also associated with participation in any organized sport (OR = 1.66, 95%CI = 1.49–1.86), and each additional hour of organized sport (OR = 1.09, 95%CI = 1.07–1.11). Although participation in recreational physical activity appears to be beneficial for wellbeing, organized sport appears to offer unique additional wellbeing benefits. Positive experiences of organized sport participation may offer additional wellbeing value above and beyond other recreational physical activity types in young people who are active.
Moral Disengagement Mechanisms and Personality Dimensions Implicit to Homophobia
Authors: González-Fuentes José Antonio , Moreno-Manso Juan Manuel , Guerrero-Molina Mónica , Guerrero-Barona Eloísa , García-Baamonde María Elena
Published: July 2022

Recent advances in sexual equality and diversity have not been able to mitigate the serious problem of discrimination suffered by sexual minorities. The most serious cases involve violence and physical or psychological aggression towards sexual orientations that differ from the heterosexual norm. This research analyses the dimensions of the personality and the moral disengagement mechanisms related to homophobia and the predictive value they have for hostile attitudes towards sexual diversity. The sample was made up of 849 university students between 18 and 24 years of age. The instruments used were the Modern Homophobia Scale (MHS), the Mechanisms of Moral Disengagement Scale (MMDS), and the reduced version of the Neo Personality Inventory—Reduced Version (NEO-FFI). The results show the involvement of moral disengagement in homophobia. It highlights evidence of subtle intimidatory behaviour patterns of rejection towards homosexuality. Furthermore, the low levels in the dimensions of a friendly personality and openness to experiences can be seen to predict homophobic behaviour. Thus, young people fall back on diverse mechanisms of moral disengagement to justify harmful attitudes towards the LGTBI collective. The results of the research are particularly relevant and useful for setting up programmes aimed at preventing and mitigating this serious problem of sexual discrimination.
Relationship of 24-Hour Movement Behaviors with Weight Status and Body Composition in Chinese Primary School Children: A Cross-Sectional Study
Authors: Zhou Lin , Liang Wei , He Yuxiu , Duan Yanping , Rhodes Ryan E. , Liu Hao , Liang Hongmei , Shi Xiaowei , Zhang Jun , Cheng Yingzhe
Published: July 2022

24 h movement behaviors, specifically physical activity (PA), sedentary behavior, and sleep, play a crucial role in the prevention and intervention of childhood obesity. This study aimed to examine the association of 24 h movement behaviors with weight status and body composition among Chinese primary school children. Using a random stratified sampling, 978 eligible participants (9.1 ± 1.4 years, 53.2% boys) were recruited from 1 May to 15 July 2021. Demographics included children’s age, gender, grade, parents’ education level, and household income. Movement behaviors were measured by validated self-reported scales. Weight status and body composition (percent of body fat, PBF; fat-free mass, FFM; skeletal muscle mass, SMM) were measured objectively. Results indicated that participants who were younger, boys, and at lower grade showed higher guidelines adherence. PA was inversely associated with PBF, while screen time (ST) was positively associated with overweight/obesity risk and FFM. Sleep showed no association with any health indicators. Meeting the behavioral guidelines was associated with better weight status and lower PBF, yet not with FFM and SMM. Interventions to improve the Children’s weight status and PBF should involve enhancing their overall movement behaviors and considering their demographic differences. More research on examining the association of movement guidelines adherence with body composition indicators is needed.
Are Farmers in National Park Communities Willing to Reallocate Their Lands? A Situational Analysis
Authors: Gao Yan , Dong Qian , Deng Yi
Published: July 2022

Limited by China’s mixed land ownership model, which is divided into collective and state ownership, national parks’ strict ecological protection measures of restricting land use patterns and intensity are subject to the decisions made by collective landowners and contract operators, namely, rural households in national park communities. The disposition and intention of community farmers regarding collective land ownership is related to the nature conservation effect of the national park. In the context of national park land functions for ecological conservation, environmental education, leisure and recreation, scientific research, and “nest eggs” (basic living guarantees), the research on the influencing factors of farmers’ intentions to reallocate their land (expropriated or transferred) will provide a basis for a National Parks Administration (NPA) to develop supporting policies for collective land reallocation in different functional zones and to prevent community conflicts. The research took Shennongjia National Park as an example and, combined with literature analysis, used the Structural Equation Model (SEM) to explore the influencing factors of community farmers’ land reallocation intentions and drew the following conclusions: farmers’ intentions to leave their land for nature conservation purposes and for urbanization purposes are different. In the five land function situations above, farmers’ perceptions of land function in national parks did not directly affect their land reallocation intentions, while their trust in the land management ability of NPA was a complete mediator. Farmers’ preferences for the economic value of land had no significant moderating effect on land reallocation intentions. Farmers’ characteristics have a moderating effect on different land function situation models. Older and less educated farmers are more likely to receive livelihood compensation rather than monetary compensation after leaving their land. Therefore, some management suggestions are put forward, such as strengthening the capacity for building national park land and other natural resources management, adapting to the collective land policy in different function zones, and paying attention to the livelihood compensation of community farmers after they leave the land.
Considerations for Training and Workforce Development to Enhance Rural and Remote Ophthalmology Practise in Australia: A Scoping Review
Authors: Obamiro Kehinde , Jessup Belinda , Allen Penny , Baker-Smith Victoria , Khanal Santosh , Barnett Tony
Published: July 2022

Australia has one of the lowest per capita numbers of ophthalmologists among OECD countries, and they predominantly practise in metropolitan centres of the country. Increasing the size and distribution of the ophthalmology workforce is of critical importance. The objective of this review was to investigate the context of rural ophthalmology training and practise in Australia and how they relate to future ophthalmology workforce development. This scoping review was informed by Arksey and O’Malley’s framework and the methodology described by Coloqhuon et al. The search yielded 428 articles, of which 261 were screened for eligibility. Following the screening, a total of 75 articles were included in the study. Themes identified relating to rural ophthalmology training and practise included: Indigenous eye health; access and utilisation of ophthalmology-related services; service delivery models for ophthalmic care; ophthalmology workforce demographics; and ophthalmology workforce education and training for rural and remote practise. With an anticipated undersupply and maldistribution of ophthalmologists in the coming decade, efforts to improve training must focus on how to build a sizeable, fit-for-purpose workforce to address eye health needs across Australia. More research focusing on ophthalmology workforce distribution is needed to help identify evidence-based solutions for workforce maldistribution. Several strategies to better prepare the future ophthalmology workforce for rural practise were identified, including incorporating telehealth into ophthalmology training settings; collaborating with other health workers, especially optometrists and specialist nurses in eyecare delivery; and exposing trainees to more patients of Indigenous background.
Spatiotemporal Variation and Driving Forces Analysis of Eco-System Service Values: A Case Study of Sichuan Province, China
Authors: He Chengjin , Shao Huaiyong , Xian Wei
Published: July 2022

Sichuan Province is an important ecological barrier in the upper reaches of the Yangtze River. Therefore, it is critical to investigate the temporal and spatial changes, as well as the driving factors, of ecosystem service values (ESVs) in Sichuan Province. This paper used land use data from 2000, 2005, 2010, 2015, and 2020 to quantify the spatiotemporal changes in the ESVs in Sichuan Province. Correlation coefficients and bivariate spatial autocorrelation methods were used to analyze the trade-offs and synergies of ESVs in the city (autonomous prefecture) and grid scales. At the same time, we used a Geographical Detector model (GDM) to explore the synergies between nine factors and ESVs. The results revealed that: (1) In Sichuan Province, the ESVs increased by 0.77% from 729.26 × 109 CNY in 2000 to 741.69 × 109 CNY in 2020 (unit: CNY = Chinese Yuan). Furthermore, ecosystem services had a dynamic degree of 0.13%. Among them, the ESVs of forestland were the highest, accounting for about 60.59% of the total value. Among the individual ecosystem services, only food production, environmental purification, and soil conservation decreased in value, while the values of other ecosystem services increased. (2) The ESVs increased with elevation, showing a spatial distribution pattern of first rising and then decreasing. The high-value areas of ESVs per unit area were primarily distributed in the forestland of the transition area between the basin and plateau; The low-value areas were distributed in the northwest, or the urban areas with frequent human activities in the Sichuan Basin. (3) The tradeoffs and synergies between multi-scale ecosystems showed that ecosystem services were synergies-dominated. As the scale of research increased, the tradeoffs between ecosystems gradually transformed into synergies. (4) The main driving factors for the spatial differentiation of ESVs in Sichuan Province were average annual precipitation, average annual temperature, and gross domestic product (GDP); the interaction between normalized difference vegetation index (NDVI) and GDP had the strongest driving effect on ESVs, generally up to 30%. As a result, the distribution of ESVs in Sichuan Province was influenced by both the natural environment and the social economy. The present study not only identified the temporal and spatial variation characteristics and driving factors of ESVs in Sichuan Province, but also provided a reference for the establishment of land use planning and ecological environmental protection mechanisms in this region.
Vaccination against COVID-19 in Europe: A Typology Based on Cluster Analysis
Authors: Cristea Darie , Zamfirache Irina , Zamfirescu Raisa-Gabriela
Published: July 2022

This study aims to identify a general typology for the EU27, and subsequently in Romania, regarding the hesitation, acceptance and refusal of vaccination against COVID-19. The analysis we propose below is based on the information contained in Eurobarometer 94.3, the data of which were collected at the beginning of most of the national vaccination campaigns in Europe. Based on the attitudes and opinions expressed by the respondents of the European states (EU27), we constructed with the help of the cluster k-means (SPSS) statistical analysis a typology with four categories on the subject of vaccination against COVID-19. Our study proposes a matrix with five items/scenarios on a scale from total agreement to total disagreement. We chose a typology with four attitudinal types (clusters). We subsequently compared the results of the general European analysis with the cluster typology resulting from the same Eurobarometer, the same set of questions, only for the case of Romania, to see if this analysis sheds a specific light on the fact that Romania had a very low vaccination rate compared to other EU Member States.
Information Needs and Counseling Preferences among Potential Users of the Future Teratology Information Service in Belgium: A Cross-Sectional Study Involving the Public and Healthcare Professionals
Authors: Ceulemans Michael , Van Calsteren Kristel , Allegaert Karel , Foulon Veerle
Published: July 2022

A Teratology Information Service (TIS) does not exist in Belgium yet but will hopefully be established soon. To prepare for this, we aimed to provide insight into the information needs and counseling preferences of the Belgian public and healthcare professionals (HCPs) regarding medication use in pregnancy and breastfeeding. A cross-sectional study using two anonymous, online surveys disseminated via social media, websites, and newsletters addressing Dutch and French-speaking individuals (≥18 years) and licensed HCPs was performed between June and September 2020. Ethics approval and informed consent were obtained. In total, 1508 public survey respondents (98% women) and 702 HCPs participated. Information needs on perinatal medication use were ubiquitous among both groups, and for which they often relied on patient information leaflets or the product information and online fora. Conflicting information on this topic regularly occurs and complicates HCPs’ duties. Women and HCPs assigned an important role to a TIS, both in terms of providing evidence-based information (via a website or app) and being accessible to be contacted in case of questions (by phone or via e-mail or chat). In conclusion, a TIS would be warmly welcomed by women and HCPs in Belgium and should ideally be established soon to address current information needs regarding perinatal medication use and to contribute to research in this field.
Accurate Extraction of Ground Objects from Remote Sensing Image Based on Mark Clustering Point Process
Authors: Zhang Hongyun , Liu Jin , Liu Jie
Published: July 2022

The geometric features of ground objects can reflect the shape, contour, length, width, and pixel distribution of ground objects and have important applications in the process of object detection and recognition. However, the geometric features of objects usually present irregular geometric shapes. In order to fit the irregular geometry accurately, this paper proposes the mark clustering point process. Firstly, the random points in the parent process are used to determine the location of the ground object, and the irregular graph constructed by the clustering points in the sub-process is used as the identification to fit the geometry of the ground object. Secondly, assuming that the spectral measurement values of ground objects obey the independent and unified multivalued Gaussian distribution, the spectral measurement model of remote sensing image data is constructed. Then, the geometric extraction model of the ground object is constructed under the framework of Bayesian theory and combined with the reversible jump Markov chain Monte Carlo (RJMCMC) algorithm to simulate the posterior distribution and estimate the parameters. Finally, the optimal object extraction model is solved according to the maximum a posteriori (MAP) probability criterion. This paper experiments on color remote sensing images. The experimental results show that the proposed method can not only determine the position of the object but also fit the geometric features of the object accurately.
The Missing Millions in Maps: Exploring Causes of Uncertainties in Global Gridded Population Datasets
Authors: Kuffer Monika , Owusu Maxwell , Oliveira Lorraine , Sliuzas Richard , van Rijn Frank
Published: July 2022

Gridded population datasets model the population at a relatively high spatial and temporal granularity by reallocating official population data from irregular administrative units to regular grids (e.g., 1 km grid cells). Such population data are vital for understanding human–environmental relationships and responding to many socioeconomic and environmental problems. We analyzed one very broadly used gridded population layer (GHS-POP) to assess its capacity to capture the distribution of population counts in several urban areas, spread across the major world regions. This analysis was performed to assess its suitability for global population modelling. We acquired the most detailed local population data available for several cities and compared this with the GHS-POP layer. Results showed diverse error rates and degrees depending on the geographic context. In general, cities in High-Income (HIC) and Upper-Middle-Income Countries (UMIC) had fewer model errors as compared to cities in Low- and Middle-Income Countries (LMIC). On a global average, 75% of all urban spaces were wrongly estimated. Generally, in central mixed or non-residential areas, the population was overestimated, while in high-density residential areas (e.g., informal areas and high-rise areas), the population was underestimated. Moreover, high model uncertainties were found in low-density or sparsely populated outskirts of cities. These geographic patterns of errors should be well understood when using population models as an input for urban growth models, as they introduce geographic biases.
MicroRNAs in Dystrophinopathy
Authors: Lee Ahyoung , Moon Jiwon , Yu Jin , Kho Changwon
Published: July 2022

Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD), which represent the range of dystrophinopathies, account for nearly 80% of muscle dystrophy. DMD and BMD result from the loss of a functional dystrophin protein, and the leading cause of death in these patients is cardiac remodeling and heart failure. The pathogenesis and progression of the more severe form of DMD have been extensively studied and are controlled by many determinants, including microRNAs (miRNAs). The regulatory role of miRNAs in muscle function and the differential miRNA expression in muscular dystrophy indicate the clinical significance of miRNAs. This review discusses the relevant microRNAs as potential biomarkers and therapeutic targets for DMD and DMD cardiomyopathy as examples of dystrophinopathies.
Vertical Integration Decision Making in Information Technology Management
Authors: Gorgun Menekse Gizem , Polat Seckin , Asan Umut
Published: July 2022

Vertical integration, also known as make-or-buy, defines whether activities are conducted by company or provided by external parties. There are different models to support decision making for vertical integration in the literature. However, they ignore the uncertainty aspect of vertical integration. As a strategic decision, vertical integration is multidimensional and less frequent. This study contributes a new data-driven model that includes all these characteristics of vertical integration decisions. In this study, a methodology is suggested that benefits from the models in the literature and assesses the results with data obtained from real IT cases. Different methodologies were followed to reach a model that accurately predicts make-or-buy decisions in IT projects at a retail company. Firstly, three different knowledge-based generic models derived from the literature were applied to predict decisions for twenty-one different make-or-buy cases in IT. The highest accuracy rate reached among these knowledge-based models was 76%. Secondly, the same cases were also analyzed with Naïve Bayes using factors originally introduced by these generic models. The Naïve Bayes algorithm can represent the uncertainty inherent in the decision model. The highest accuracy rate obtained was 67%. Thirdly, a new data-driven model based on Naïve Bayes using IT-related factors was proposed for the decision problem of vertical integration. The data-driven model correctly classified 86% of the decisions.
How Age and Gender Affect the Opinions of Computing Students Regarding Computer Usage and Design Needs
Authors: Hallewell Haslwanter Jean D. , Takacs Christiane , Gaisch Martina
Published: July 2022

This study aimed to understand the perceptions of young computing science students about women and older people with regard to their computer literacy and how this may affect the design of computer-based systems. Based on photos, participants were asked how likely they thought the person depicted would be to use desktop computers, laptops and smartphones, and how much expertise they thought they would have with each technology. Furthermore, in order to see what impact this could have on systems being developed, we asked what design aspects would be important for the depicted person and whether they thought an adapted technology would be required. This study is based on an existing questionnaire, which was translated into German and extended to explore what impact this may have on system design. The results draw on 200 questionnaires from students in the first year of their Information and Communications Technology (ICT) studies at an Austrian university of applied sciences. Quantitative methods were used to determine if the perceptions varied significantly based on the age and gender of the people depicted. Qualitative analysis was used to evaluate the design aspects mentioned. The results show that there are biases against both older people and women with respect to their perceived expertise with computers. This is also reflected in the design aspects thought to be important for the different cohorts. This is crucial as future systems will be designed by the participants, and these biases may influence whether future systems meet the needs and wishes of all groups or increase the digital divide.
Back to the Wild: The Parasitoid Community of Lobesia botrana (Lepidoptera: Tortricidae) in a Grapevine-Free Natural Environment
Authors: Di Giovanni Filippo , Ricciardi Renato , Loni Augusto , Scaramozzino Pier Luigi , Benelli Giovanni , Lucchi Andrea
Published: July 2022

The European grapevine moth (EGVM), Lobesia botrana (Lepidoptera: Tortricidae), is one of the major concerns for vineyard managers in the Mediterranean area. It is a polyphagous moth, which develops on a wide variety of host plants, among which the spurge flax, Daphne gnidium (Thymelaeaceae), very likely represents its originary wild host plant. In this study, we investigated the parasitoid complex of L. botrana feeding on D. gnidium during a three-year sampling in a natural reserve in Tuscany, Italy, where this plant is extremely abundant while the grapevine is absent. A total of 24 species of parasitoids were obtained from eggs, larvae, and pupae of EGVM, belonging to 6 families of Hymenoptera and a family of Diptera. The ichneumonid wasp Campoplex capitator was the most abundant larval parasitoid. Four species of the genus Trichogramma were obtained from parasitized eggs during the first year of sampling, with a peak in the parasitisation during the EGVM 3rd generation. Some of the main EGVM parasitoids on spurge flax were also observed in vineyards, although a certain degree of redundancy was observed in the wild, due to several less frequent “satellite” species exploiting the same host. Overall, this research sheds light on the parasitoid community and dynamics of this important moth pest in a grapevine-free natural ecosystem, discussing the possible role of natural areas as ecological reservoirs of pest natural enemies.
Fumigant Activity of Ethyl Formate against the Chestnut Weevil, Curculio sikkimensis Heller
Authors: Kwon Tae Hyung , Lee Byungho , Kim Junheon
Published: July 2022

Castanea crenata Siebold & Zucc. (Fagales: Fagaceae), a species of chestnut native to Korea and Japan, is distributed in Korea, Japan, and northeastern China, where chestnuts are a major economic agroforest product. Curculio spp. is among the main known pests of chestnuts around the world. In Korea, only phosphine (PH3) is permitted for the fumigation of C. sikkimensis larva-infested chestnuts. However, it is applied for large-scale fumigation, and its use is restricted. Moreover, it requires a long exposure time and an application device; thus, it cannot be used by small-scale farmers. In this study, the activity of ethyl formate (EF) as a fumigant against Curculio sikkimensis in chestnuts was investigated, and its potential for practical use by farmers was evaluated. The sorption of EF according to the filling ratio (FR) and fumigation time was tested, and the results revealed that 2.5% FR was the most effective. For C. sikkimensis in chestnuts, the mortality rate increased proportionately with the dose of EF. After exposure to 160 g/m3 of EF in a 12 L desiccator, the adult C. sikkimensis showed 100% mortality. According to the time–dose mortality data collected over 12 h of fumigation, the LCT90 and LCT99 values were estimated as 1052.0 and 1952.0 g·h/m3. The results revealed that immersion was not an effective method for controlling C. sikkimensis. According to the LCT values, a dose of 180.0 g/m3 and 12 h of fumigation resulted in 100% mortality on a small scale (2 m3). The results of this experiment indicate that EF could be conveniently used as a fumigant by farmers.
30-Day Outcomes after Surgical or Transapical Aortic Valve Replacement in Symptomatic Aortic Regurgitation
Authors: Kong Minjian , Hong Ze , Liu Xianbao , Zhu Xian , Wang Jianan , Dong Aiqiang
Published: July 2022

Background: We aimed to analyze the short-term clinical outcomes of transapical aortic valve replacement (TA-TAVR) compared with surgical aortic valve replacement (SAVR) in symptomatic aortic regurgitation (AR) patients to draw preliminary conclusions about the advantages and disadvantages of TA-TAVR compared with SAVR and to provide evidence for future use of TA-TAVR in AR patients. Method: From September 2016 to September 2021, 69 patients undergoing TA-TAVR with J-valve implantation and 42 patients undergoing SAVR at the Second Hospital of Zhejiang University School of Medicine were analyzed for clinical data and 30-day follow-up outcomes to analyze and compare the differences in clinical endpoints between the two procedures. Results: At 30-day follow-up, there were no significant differences in mortality or neurological events between the two groups before and after the PSM. In secondary endpoints there were significant differences between the pre-match TAVR and SAVR groups, such as the incidence of paravalvular leaks (33.8% vs. 4.8%, p < 0.05), which also remained after the PSM (37.5% vs. 0, p < 0.05). In addition, the incidence of major bleeding was 7.4% in the TAVR group and 26.2% in the SAVR group before matching (p < 0.05). After matching, the statistical difference still remained. In longitudinal comparison, significant improvements in postoperative cardiac ultrasound indices and NYHA classification occurred in both groups. Conclusion: The TA-TAVR approach is safe and reliable, with similar clinical efficacy to SAVR, and has advantages in bleeding rate and speed of recovery.
Cardiotoxicity of Chemical Substances: An Emerging Hazard Class
Authors: Georgiadis Nikolaos , Tsarouhas Konstantinos , Dorne Jean-Lou C. M. , Kass George E. N. , Laspa Petroula , Toutouzas Konstantinos , Koulaouzidou Elisabeth A. , Kouretas Dimitrios , Tsitsimpikou Christina
Published: July 2022

(1) Background: Human health risks and hazards from chemical substances are well regulated internationally. However, cardiotoxicity, is not defined as a stand-alone hazard and therefore there are no defined criteria for the classification of substances as cardiotoxic. Identifying and regulating substances that cause cardiovascular adverse effects would undoubtedly strengthen the national health systems. (2) Methods: To overcome the aforementioned gap, a roadmap is proposed for identifying regulatory criteria from animal studies and endorse legislation in order to classify substances as cardiotoxic. The roadmap consists of: (i) the identification of the appropriate animal species and strains; (ii) the identification of the lines of scientific evidence (e.g., histopathological, biochemical and echocardiographic indices etc.) from animal studies with relevance to humans; (iii) the statistical analysis and meta-analysis for each line of scientific evidence after exposure to well-established cardiotoxicants to humans (e.g., anthracyclines) in order to identify threshold values or range of normal and/ or altered values due to exposure; (iv) validation of the above described lines of evidence in animals exposed to other alleged cardiotoxic substances (e.g., anabolic androgen steroids (AAS) and pesticides); (v) establishment of mechanisms of action based on information of either known or alleged cardiotoxicants; and (vi) introduction of novel indices and in silico methods. (3) Results: Preliminary results in rats indicate a clear distinction from normal values to values measured in rats exposed to anthracyclines regarding left ventricle (LV) fractional shortening (FS) and LV ejection fraction (EF). A distinctive pattern is similarly observed for Creatine Kinase-Myocardial Band isoenzyme (CK-MB) and cardiac tissue glutathione (GSH). These findings are encouraging and indicate that there is room for targeted research to this end, and that these specific indices and biochemical markers should be further investigated in order to be developed to regulatory criteria. (4) Conclusions: Further research should be conducted by both the scientific and regulatory community that aims to clearly define the cardiotoxicity hazard caused by chemicals and develop a full set of scientific criteria.
Assistive Technology in Multiple Sclerosis Patients—Two Points of View
Authors: Korchut Agnieszka , Petit Veronique , Szwedo-Brzozowska Ewelina , Rejdak Konrad
Published: July 2022

Objective: The goal of our study was determining the current needs and acceptance of patients with multiple sclerosis (MS) in the field of assistive technologies using materials from the “RAMCIP” project (Robotic Assistant for Mild Cognitive Impairment Patient at Home). Methods: There were two target groups: a population with MS, and medical personnel experienced in treating MS patients. This study was based on a two-step design method (workshops and surveys). Using the Likert scale, we identified the prioritization of users’ needs. Additionally, demographic and disease-specific data and their correlations with each other and with the level of priority of functionality were analyzed. Moreover, the acceptance aspect of the assistant robot and the respondents’ readiness to use it were determined. Results: We gathered 307 completed surveys (176 from MS patients, 131 from medical personnel). Functional capabilities from the safety category were a high priority in most cases. The medium priority functions concerned daily activities that required physical assistance and home management. The differences in prioritization between the two groups were also found. Variables such as age, level of disability, cognitive impairment, depression, and fatigue were associated with the priority level of the functionalities. Conclusion: In summary, our findings might contribute to a better adaptation of robotic assistants to the needs and expectations of the MS population.
Sleep Quality and Insomnia Severity among Italian University Students: A Latent Profile Analysis
Authors: Carpi Matteo , Marques Daniel Ruivo , Milanese Alberto , Vestri Annarita
Published: July 2022

Insomnia is a widespread sleep disorder associated with physical and mental health conditions. Although the heterogeneity of insomnia presentations has been acknowledged, research investigating clinically meaningful insomnia subtypes is still ongoing. This study aimed at exploring insomnia subtypes according to widely-used measures of symptoms severity and sleep quality among Italian university students using a latent profile analysis. Data were collected from 490 students reporting relevant insomnia symptoms through an online cross-sectional survey comprising the Insomnia Severity Index, the Pittsburgh Sleep Quality Index, the 21-item Depression Anxiety Stress Scale, and the Short Form-12. Latent profile analysis identified five insomnia subtypes. The severe insomnia (8.8%) group showed the highest insomnia severity, with diverse complaints concerning sleep quality and daytime functioning. Moderate insomnia with sleep duration complaints (8.4%) and moderate insomnia with medication use (15.9%) subgroups were characterized by middle range insomnia severity, with problems of sleep continuity and sleep medication use, respectively. Subthreshold insomnia with sleep latency complaints (20.4%) and subthreshold insomnia (46.5%) groups showed attenuated insomnia symptoms. Higher psychological complaints and worse quality of life were associated with greater sleep complaints. Overall, these findings highlight the relevance of sleep quality domains in identifying insomnia subtypes and might help optimize insomnia treatments.
Misleading Meta-Analyses during COVID-19 Pandemic: Examples of Methodological Biases in Evidence Synthesis
Authors: Llanaj Erand , Muka Taulant
Published: July 2022

Not all evidence is equal. Evidence-based public health and medicine emanate from the principle that there is a hierarchy of evidence, with systematic reviews and meta-analyses (SRMAs) being at the top, as the highest level of evidence. Despite this, it is common in literature to find SRMAs with methodological issues that can distort the results and can thus have serious public health or clinical implications. During the Coronavirus Disease 2019 (COVID-19) pandemic, the importance of evidence and the way in which evidence was produced was stress tested and revealed a wide array of methodological biases that might have led to misleading conclusions and recommendations. We provide a critical examination of methodological biases in selected SRMAs on COVID-19, which have been widely used to guide or justify some pharmaceutical and nonpharmaceutical interventions with high public health and clinical significance, such as mask wearing, asymptomatic transmission, and ivermectin. Through these selected examples, we highlight the need to address biases related to the methodological quality and relevance of study designs and effect size computations and considerations for critical appraisal of available data in the evidence synthesis process for better quality evidence. Such considerations help researchers and decision makers avoid misleading conclusions, while encouraging the provision of the best policy recommendations for individual and public health.