bluuebunny/crossref_metadata_2025 huggingface dataset:
Assessment of Correlation between Dual-Energy Ct (De-Ct)-Derived Iodine Concentration and Local Flourodeoxyglucose (Fdg) Uptake in Patients with Primary Non-Small-Cell Lung Cancer
Authors: Andersen Michael Brun , Drljevic-Nielsen Aska , Thygesen Jesper , Kruis Matthijs Ferdinand , Hjorthaug Karin , Rasmussen Finn , Nijkamp Jasper Albertus
Published: July 2022

(1) The current literature contains several studies investigating the correlation between dual-energy-derived iodine concentration (IC) and positron emission tomography (PET)-derived Flourodeoxyglucose (18F-FDG) uptake in patients with non-small-cell lung cancer (NSCLC). In previously published studies, either the entire tumor volume or a region of interest containing the maximum IC or 18F-FDG was assessed. However, the results have been inconsistent. The objective of this study was to correlate IC with FDG both within the entire volume and regional sub-volumes of primary tumors in patients with NSCLC. (2) In this retrospective study, a total of 22 patients with NSCLC who underwent both dual-energy CT (DE-CT) and 18F-FDG PET/CT were included. A region of interest (ROI) encircling the entire primary tumor was delineated, and a rigid registration of the DE-CT, iodine maps and FDG images was performed for the ROI. The correlation between tumor measurements and area-specific measurements of ICpeak and the peak standardized uptake value (SUVpeak) was found. Finally, a correlation between tumor volume and the distance between SUVpeak and ICpeak centroids was found. (3) For the entire tumor, moderate-to-strong correlations were found between SUVmax and ICmax (R = 0.62, p = 0.002), and metabolic tumor volume vs. total iodine content (R = 0.91, p < 0.001), respectively. For local tumor sub-volumes, a negative correlation was found between ICpeak and SUVpeak (R = −0.58, p = 0.0046). Furthermore, a strong correlation was found between the tumor volume and the distance in millimeters between SUVpeak and ICpeak centroids (R = 0.81, p < 0.0001). (4) In patients with NSCLC, high FDG uptakes and high DE-CT-derived iodine concentrations correlated on a whole-tumor level, but the peak areas were positioned at different locations within the tumor. 18F-FDG PET/CT and DE-CT provide complementary information and might represent different underlying patho-physiologies.
Neurotoxicity of Environmental Metal Toxicants: Special Issue
Authors: Ortega Richard , Carmona Asuncion
Published: July 2022

Environmental exposure to metallic neurotoxicants is a matter of growing concern, since it may have very significant consequences for human health, from impairing neurodevelopment in children to the neurodegeneration processes involved in aging [...]
Occurrence and Characterization of Small Microplastics (<100 μm), Additives, and Plasticizers in Larvae of Simuliidae
Authors: Corami Fabiana , Rosso Beatrice , Iannilli Valentina , Ciadamidaro Simone , Bravo Barbara , Barbante Carlo
Published: July 2022

This study is the first to investigate the ingestion of microplastics (MPs), plasticizers, additives, and particles of micro-litter < 100 μm by larvae of Simuliidae (Diptera) in rivers. Blackflies belong to a small cosmopolitan insect family whose larvae are present alongside river courses, often with a torrential regime, up to their mouths. Specimens of two species of blackfly larvae, Simulium equinum and Simulium ornatum, were collected in two rivers in Central Italy, the Mignone and the Treja. Small microplastics (SMPs, <100 μm), plasticizers, additives, and other micro-litter components, e.g., natural and non-plastic synthetic fibers (APFs) ingested by blackfly larvae were, for the first time, quantified and concurrently identified via MicroFTIR. The pretreatment allowed for simultaneous extraction of the ingested SMPs and APFs. Strong acids or strong oxidizing reagents and the application of temperatures well above the glass transition temperature of polyamide 6 and 6.6 (55–60 °C) were not employed to avoid further denaturation/degradation of polymers and underestimating the quantification. Reagent and procedural blanks did not show any SMPs or APFs. The method’s yield was >90%. Differences in the abundances of the SMPs and APFs ingested by the two species under exam were statistically significant. Additives and plasticizers can be specific to a particular polymer; thus, these compounds can be proxies for the presence of plastic polymers in the environment.
Cytotoxic and Hemolytic Activities of Extracts of the Fish Parasite Dinoflagellate Amyloodinium ocellatum
Authors: Moreira Márcio , Soliño Lucía , Marques Cátia L. , Laizé Vincent , Pousão-Ferreira Pedro , Costa Pedro Reis , Soares Florbela
Published: July 2022

The dinoflagellate Amyloodinium ocellatum is the etiological agent of a parasitic disease named amyloodiniosis. Mortalities of diseased fish are usually attributed to anoxia, osmoregulatory impairment, or opportunistic bacterial infections. Nevertheless, the phylogenetic proximity of A. ocellatum to a group of toxin-producing dinoflagellates from Pfiesteria, Parvodinium and Paulsenella genera suggests that it may produce toxin-like compounds, adding a new dimension to the possible cause of mortalities in A. ocellatum outbreaks. To address this question, extracts prepared from different life stages of the parasite were tested in vitro for cytotoxic effects using two cell lines derived from branchial arches (ABSa15) and the caudal fin (CFSa1) of the gilthead seabream (Sparus aurata), and for hemolytic effects using erythrocytes purified from the blood of gilthead seabream juveniles. Cytotoxicity and a strong hemolytic effect, similar to those observed for Karlodinium toxins, were observed for the less polar extracts of the parasitic stage (trophont). A similar trend was observed for the less polar extracts of the infective stage (dinospores), although cell viability was only affected in the ABSa15 line. These results suggest that A. ocellatum produces tissue-specific toxic compounds that may have a role in the attachment of the dinospores’ and trophonts’ feeding process.
Immunogenicity of BNT162b2 Vaccination against SARS-CoV-2 Omicron Variant and Attitudes toward a COVID-19 Booster Dose among Healthy Thai Adolescents
Authors: Assavavongwaikit Pavinee , Chantasrisawad Napaporn , Himananto Orawan , Phasomsap Chayapa , Klawaja Pintusorn , Cartledge Sapphire , Nadsasarn Rachaneekorn , Jupimai Thidarat , Kawichai Surinda , Anugulruengkitt Suvaporn , Puthanakit Thanyawee , on behalf of the Study Team
Published: July 2022

Despite the BNT162b2 vaccination coverage, rapid transmission of Omicron SARS-CoV-2 has occurred, which is suspected to be due to the immune escape of the variant or waning vaccine efficacy of multiple BNT162b2 vaccination doses. Our study aims to compare immunogenicity against Omicron prior to and post a booster dose of BNT162b2 in healthy adolescents, and to evaluate their attitudes toward booster dose vaccination. A cross sectional study was conducted among healthy adolescents aged 12–17 who received two doses of BNT162b2 more than 5 months ago. Participants and their guardians performed self-reported questionnaires regarding reasons for receiving the booster. A 30 ug booster dose of BNT162b2 was offered. Immunogenicity was evaluated by a surrogate virus neutralization test (sVNT) against the Omicron variant, and anti-spike-receptor-binding-domain IgG (anti-S-RBD IgG) taken pre-booster and 14-days post-booster. From March to April 2022, 120 healthy Thai adolescents with a median age of 15 years (IQR 14–16) were enrolled. sVNT against Omicron pre- and post-booster had 11.9 (95%CI 0–23.9) and 94.3 (90.6–97.4) % inhibition. Geometric means (GMs) of anti-S-RBD IgG increased from 837 (728, 953) to 3041 (2893, 3229) BAU/mL. Major reasons to receive the booster vaccination were perceived as vaccine efficacy, reduced risk of spreading infection to family, and safe resumption of social activities. A booster dose of BNT162b2 elicits high immunogenicity against the Omicron variant. Motivation for receiving booster doses is to reduce risk of infection.
Immunohistochemical Expression of Platelet-Derived Growth Factor Receptor β (PDGFR-β) in Canine Cutaneous Peripheral Nerve Sheath Tumors: A Preliminary Study
Authors: Aluai-Cunha Catarina , Matos Augusto , Amorim Irina , Carvalho Fátima , Rêma Alexandra , Santos Andreia
Published: July 2022

As in humans, the prevalence of tumors in companion animals is increasing dramatically and there is a strong need for research on new pharmacological agents particularly for the treatment of those tumors that are resistant to conventional chemotherapy agents such as soft tissue sarcomas (STS). Because malignant (MPNST) and benign peripheral nerve sheath tumors (BPNST) are relatively common STS in dogs, the aim of this retrospective study was to evaluate the immunohistochemical (IHC) expression of PDGFR-β, contributing to its characterization as a potential target for their treatment. A total of 19 samples were included, 9 histologically classified as benign and the other 10 as malignant. The results showed diffuse immunoexpression in the cytoplasm of neoplastic cells. Six (66.7%) BPNST expressed the receptor in less than 25% of neoplastic cells and only three (33.3%) exhibited labelling in more than 25% of neoplastic cells. In contrast, all MPNST expressed PDGFR-β, and in 8 (80%) of these samples, the receptor was expressed in more than 25% of neoplastic cells, and only 2 (20%) cases expressed the receptor in less than 25% of neoplastic cells. PDGFR-β expression was significantly higher in MPNST and larger tumors, suggesting that drugs able to inhibit the activity of this tyrosine kinase receptor, such as toceranib, may be considered in the approach of unresectable tumors and/or in the context of adjuvant or neoadjuvant therapies.
Anticoccidial Vaccination Is Associated with Improved Intestinal Health in Organic Chickens
Authors: Jansson Désirée S. , Höglund Johan , Bagge Elisabeth , Jinnerot Tomas , Kaldhusdal Magne
Published: July 2022

Eimeria spp. and Clostridium perfringens (CP) are pathogens associated with coccidiosis and necrotic enteritis (NE) in broiler chickens. In this study we evaluated the effect of anticoccidial vaccination on intestinal health in clinically healthy organic Ross 308 chickens. On each of two farms, one unvaccinated flock (A1 and B1) was compared to one vaccinated flock (A2 and B2) until ten weeks of age (WOA). Faecal oocysts were counted weekly, and species were identified by PCR (ITS-1 gene). Lesion scoring, CP quantification and PCR targeting the CP NetB toxin gene were performed at three, four, and six WOA and chickens were weighed. Necropsies were performed on randomly selected chickens to identify coccidiosis/NE. Oocyst shedding peaked at three WOA in all flocks. Later oocyst shedding (E. tenella/E. maxima) in unvaccinated flocks at 5–7 WOA coincided with coccidiosis/NE. Although results differed somewhat between farms, vaccination was associated with lower intestinal lesion scores, reduced caecal CP counts, lower proportions of netB-positive CP, lower body weight at three–four WOA, and similar or slightly increased body weight at six WOA. In conclusion, the intestinal health of organic broilers can benefit from anticoccidial vaccination when oocyst exposure levels are high.
Willingness to Pay for Improved Urban Domestic Water Supply System: The Case of Hanoi, Vietnam
Authors: Bui Nuong Thi , Darby Stephen , Vu Trang Quynh , Mercado Jean Margaret R. , Bui Thao Thi Phuong , Kantamaneni Komali , Nguyen Thuong Thi Hoai , Truong Tu Ngoc , Hoang Hue Thi , Bui Duong Du
Published: July 2022

Access to a reliable and safe domestic water supply is a serious challenge for many developing countries worldwide. In the capital of Vietnam, Hanoi, the municipal government is facing a number of difficulties in providing sufficient water in a sustainable manner due to the increasing urban population and the serious pollution of both surface and groundwater resources, but this is also due to a lack of resources to invest in the supply system. This study aimed to investigate water users’ willingness to pay for the improvement of Hanoi’s domestic water supply system. A contingent valuation process based on a survey of 402 respondents was used to explore citizens’ willingness to pay (WTP) for the improvement of their urban water supply. The results show that Hanoi’s urban communities (more than 90%) were generally satisfied with the quantity of their water supply, but tended to be dissatisfied with its quality, with 80% of the respondents using advanced water purifiers before drinking and cooking. Respondents were also concerned about the overall reliability of the service, with 40% of respondents indicating that they received no check and maintenance service. A WTP regression model was developed based on the survey findings. The average WTP is 281,000 dong/household/month (approximately 12.2 USD at the exchange rate of 1 USD to about 23,000 VND), equivalent to 1.4% of the average household income at the end of 2019, indicating the level of affordability of monthly water payments among Hanoi citizens.
Nanoplastic-Induced Nanostructural, Nanomechanical, and Antioxidant Response of Marine Diatom Cylindrotheca closterium
Authors: Mišić Radić Tea , Vukosav Petra , Komazec Bruno , Formosa-Dague Cécile , Domazet Jurašin Darija , Peharec Štefanić Petra , Čačković Andrea , Juraić Krunoslav , Ivošević DeNardis Nadica
Published: July 2022

The aim of this study was to examine the effect of positively charged (amine-modified) and negatively charged (carboxyl-modified) polystyrene nanoplastics (PS NPs) on the nanostructural, nanomechanical, and antioxidant responses of the marine diatom Cylindrotheca closterium. The results showed that both types of PS NPs, regardless of surface charge, significantly inhibited the growth of C. closterium during short-term exposure (3 and 4 days). However, longer exposure (14 days) to both PS NPs types did not significantly inhibit growth, which might be related to the detoxifying effect of the microalgal extracellular polymers (EPS) and the higher cell abundance per PS NPs concentration. The exposure of C. closterium to both types of PS NPs at concentrations above the corresponding concentrations that resulted in a 50% reduction of growth (EC50) demonstrated phytotoxic effects, mainly due to the excessive production of reactive oxygen species, resulting in increased oxidative damage to lipids and changes to antioxidant enzyme activities. Diatoms exposed to nanoplastics also showed a significant decrease in cell wall rigidity, which could make the cells more vulnerable. Atomic force microscopy images showed that positively charged PS NPs were mainly adsorbed on the cell surface, while both types of PS NPs were incorporated into the EPS that serves to protect the cells. Since microalgal EPS are an important food source for phytoplankton grazers and higher trophic levels, the incorporation of NPs into the EPS and interactions with the cell walls themselves may pose a major threat to marine microalgae and higher trophic levels and, consequently, to the health and stability of the marine ecosystem.
Geochemical Characterization of Natural Groundwater on the Southern Slopes of the Caucasus Mountains on the Russian Black Sea Coast
Authors: Zakharikhina Lalita , Litvinenko Yury , Ryndin Alexey , Saburov Ruslan , Shevelev Sergey , Vareljyan Georgy
Published: July 2022

The Mzymta and Sochi watersheds, located on the southern slopes of the Caucasus Mountains on Russia’s Black Sea coast, are characterized by a remarkably complex geological setting. The predominant rocks are mudstones, siltstones, and shales, with smaller amounts of carbonate and clay-carbonate rocks, and occasionally igneous rocks. The area is also characterized by the occurrence of polymetallic, gold, sulfide, rare metal, and rare-earth mineralizations in addition to hosting a thermal hydrogen sulfide groundwater aquifer. The objective of this study was to determine groundwater genesis patterns in an area with such contrasting geological and hydrogeological structures. Based on the chemical analysis of 33 natural groundwater springs, five chemical types of water were identified dictated by the composition of the host rock as well as the occurrence of mineralizations, seepage of mineralized water, and local geochemical features of the host rock. The high sodium concentration and mineralization of groundwater near the thermal hydrogen sulfide groundwater aquifer are due to the infiltration of seawater. The consistent presence of excessive amounts of rare-earth elements (REEs) in all groundwaters in the area is a reflection of the regional geochemical specialization of the rocks. Groundwater, like the terrestrial components of the natural environment, inherits rare-earth fractionation patterns from the rocks that make up the area. Thus, rare-earth totals and fractionation patterns can be used as a reliable criterion to interpret the regional specificity of groundwater.
A Preliminary Study on the Mechanisms of Growth and Physiological Changes in Response to Different Temperatures in Neopyropia yezoensis (Rhodophyta)
Authors: Yin Jiao , Lu Aiming , Che Tuanjie , He Lihong , Shen Songdong
Published: July 2022

As an economically valuable red seaweed, Neopyropia yezoensis (Rhodophyta) is cultivated in intertidal areas, and its growth and development are greatly influenced by environmental factors such as temperature. Although much effort has been devoted to delineating the influence, the underlying cellular and molecular mechanisms remain elusive. In this study, the gametophyte blades and protoplasts were cultured at different temperatures (13 °C, 17 °C, 21 °C, 25 °C). Only blades cultured at 13 °C maintained a normal growth state (the relative growth rate of thalli was positive, and the content of phycobiliprotein and pigments changed little); the survival and division rates of protoplasts were high at 13 °C, but greatly decreased with the increase in temperature, suggesting that 13 °C is suitable for the growth of N. yezoensis. In our efforts to delineate the underlying mechanism, a partial coding sequence (CDS) of Cyclin B and the complete CDS of cyclin-dependent-kinase B (CDKB) in N. yezoensis were cloned. Since Cyclin B controls G2/M phase transition by activating CDK and regulates the progression of cell division, we then analyzed how Cyclin B expression in the gametophyte blades might change with temperatures by qPCR and Western blotting. The results showed that the expression of Cyclin B first increased and then decreased after transfer from 13 °C to higher temperatures, and the downregulation of Cyclin B was more obvious with the increase in temperature. The phosphorylation of extracellular signal-regulated kinase (ERK) decreased with the increase in temperature, suggesting inactivation of ERK at higher temperatures; inhibition of ERK by FR180204 significantly decreased the survival and division rates of protoplasts cultured at 13 °C. These results suggest that downregulation of Cyclin B and inactivation of ERK might be involved in negatively regulating the survival and division of protoplasts and the growth of gametophyte blades of N. yezoensis at high temperatures.
Analysis of the Remediation of Coal Tar-Contaminated Groundwater Using Ex Situ Remediation
Authors: Marschalko Marian , Kempa Tomas , Popielarczyk Dariusz , Cernik Miroslav , Vicherkova Michaela , Vicherek Petr , Niemiec Dominik
Published: July 2022

The article describes the remediation of contaminated groundwater during the ex situ remediation of coal tar contamination following the closure of a coking plant in the Moravian–Silesian Region (Czech Republic). The aim of the article is to point out the advantages of ex situ soil remediation via the excavation of the contaminated geological environment combined with thermal desorption, a method of removing contaminants both from soil and groundwater. Its advantage is the absolute qualitative and quantitative control over the contaminated soil with the possibility of precise segmentation into contaminated and non-contaminated soils. Next, all contaminated groundwater may be pumped off upon the construction of sealing walls to control groundwater flows. To excavate the soil, it is necessary to reduce the contaminated groundwater level inside the sealing walls and thus create conditions for the extraction of contaminated soils using standard machinery. In detail, the article describes the removal of the contaminated groundwater and compares the quality of the pumped and inflowing water before and after the remediation. The locality is characteristic of a high horizontal and vertical grain-size heterogeneity of gravel-sand, which led to a varying filtration coefficient affecting the capacities of pumped groundwater quantity during the remediation. At the start of the remediation process, the contaminant levels exceeded the limits by the Czech Environmental Inspectorate several times. The post-remediation monitoring showed that all the contaminant levels were below the limit. Surprisingly, the overall groundwater contamination amounted to 232.86 t of contaminants as non-aqueous phase liquids, and 6872.9 kg of dissolved contaminants. As much as 12,200 t of contaminants were removed from the soil.
Environmental Drivers and Aquatic Ecosystem Assessment of Periphytic Algae at Inflow Rivers in Six Lakes over the Yangtze River Basin
Authors: Hu Yuxin , Zhang Jing , Huang Jie , Hu Sheng
Published: July 2022

Periphytic algae is frequently utilized as a health indicator for ecosystems. Many research studies have been conducted in China on the periphytic algae community, but none has compared the periphytic algae community structure at inflow rivers among different lakes in the Yangtze river basin. The periphytic algae were investigated at 94 sites in inflow rivers of Dianchi Lake, Danjiangkou Reservoir, Dongtinghu Lake, Poyanghu Lake, Chaohu Lake, and Taihu Lake. Based on microscopic research, eight phyla and 126 genera of periphytic algae were found in the inflow river of six lakes, with Cyanobacteria and Bacillariophyta dominating. The CCA (Canonical Correspondence Analysis) was used to analyze the association between the periphytic algae community and environmental factors in the inflow river of six lakes, and the LefSe (Linear discriminant analysis effect size) analysis was used to find enriched species in the inflow river of six lakes. We discovered that TN (total nitrogen) and TP (total phosphorus) were the driving environment variables at the basin scale based on the combined results of the CCA and the Mantel Test. The TITAN (Threshold Indicator Taxa Analysis) analysis also revealed the indicator species and their TN and TP concentration thresholds. Finally, we assessed the ecosystem health of the inflow river at six lakes; biotic and abiotic indices yielded conflicting results, but utilizing both indices to assess ecosystem health using the Random Forest algorithm will yield objective and comprehensive results.
L’allongement de la durée d’assurance a-t-il atteint sa cible ? Une analyse à partir des données de la Cnav
Authors: Benallah Samia , Dardier Agathe
Published: July 2022

The 1993 French pension reform reinforced incentives to delay retirement through the increase in the contribution period required to obtain a full pension. The aim is to raise the effective retirement age, thereby extending the duration of careers. Thosewho beganworking at an early agewere considered more vulnerable and were therefore supposed to be exempted from this measure. In this paper, we propose a detailed description of individuals impacted by this reform. More precisely, we examine the extent to which these individuals correspond to the original intended target of French policymakers. We use administrative data fromCNAV, the French basic pension scheme. These data allow us to identify individuals affected by the reform and to precisely describe their professional trajectories. Lastly, we measure the retirement behaviors of individuals impacted by this pension reform, according to their professional trajectories.
Encadrement des loyers à Paris : les logements à petites pièces plus contraints que les autres
Authors: Malard Louis , Poulhès Mathilde
Published: July 2022

The municipality of Paris decided in August 2015 to renew its approach to rent control. New rents were not to exceed a given ceiling, being capped at the median rent per square metre plus 20%, for each category of dwelling (number of rooms, neighbourhood, and period of construction). This paper analyses the effects of the policy. We showthat the ceilingmet with only partial compliance, as 20% of rents exceeded the ceiling after August 2015. We then demonstrate the distortive effect of the rent control design. Ceilings were based on the number of rooms and failed to recognise that floor area can vary widely between dwellings with the same number of rooms. Dwellings with small rooms were more constrained by the rent ceilings, and were the only dwellings for which rents fell following implementation of the new controls.
Avant-gardism in the work of director Andrii Zholdak: Ukrainian and global context
Authors: Sovhyra Tetiana , Tatarenko Maryna , Kasianenko Andrii , Skrypnyk Yevheniia , Belymenko Liliana
Published: July 2022

The article deals with the essence of avant-gardism in art (theater, cinema, music). The study aims to analyze the avant-garde techniques in dramatic productions directed by A. Zholdak. The representatives of the avant-garde direction in the works of different countries of the world are marked and the historical aspect of the emergence of avant-gardism in theatrical art is briefly outlined. The main life stages of Zholdak's formation as a creative unit are elaborated on the basis. Noted individual features and ways of presenting interpreted performances, including the integration of political issues in the content of the work, the play on the contrasts, the emphasis on the role and meaning of the theatrical space, dynamism. The research methodology is based on the principles of objectivity, historicism, multifactoriality, systematicity, complexity, development, and pluralism. Examples of the main controversial productions of classical plays in the interpretation of the famous director AndriiZholdak are given. Also described are the attitudes of the public in different European countries, including Ukraine, to the work of AndriiZholdak as an innovator and avant-garde artist. The peculiarities of the audience's perception of AndriiZholdak's productions in different European countries are indicated.
The communication and acceptance of chinese films and TV series in Kazakhstan in the context of overseas promotion of chinese
Authors: Chunlei Yang , Liyun Yang
Published: July 2022

Kazakhstan is the largest country in Central Asia, and its cooperation with China in economic and cultural aspects is increasingly close. Studying the communication and acceptance of Chinese film and TV series in Kazakhstan can better understand the acceptance and cognition of Chinese culture by the Central Asian people. Based on data analysis and literature research methods, this paper reviews the history of communication and current situation of Chinese films and TV series in Kazakhstan, uses questionnaires to explore the ways and effects of communication of Chinese film and TV series in Kazakhstan, and analyzes the perception of different types of Chinese film and TV series by Kazakhstan audience. It also pointed out a series of problems existing in the communication and promotion of Chinese films and TV series in Kazakhstan: the cultural differences between China and Kazakhstan, the low quality of subtitle translation of film and TV series, and the lack of adequate publicity. Some suggestions are proposed to promote the promotion of Chinese film and TV series in Kazakhstan and Central Asia, so as to promote the in-depth exchange and cooperation of film and television culture in countries along the Belt and Road.
Tolerance and social inclusion as a condition for successful rehabilitation of persons with disabilities
Authors: Miliutina Kateryna , Chuiko Olena , Legka Viktoria , Shkuro Valentyna
Published: July 2022

The academic paper is devoted to studying the features of the attitude of teachers, parents, employers towards people from different social groups in need of social inclusion and rehabilitation. A survey of 120 people (40 primary school teachers, 40 parents of healthy children, 40 employees of the State Employment Service of Ukraine) was conducted on their attitude to people in need of social-psychological and social-labour rehabilitation. The survey was conducted in 2 stages. At the first stage, it has been found out whom exactly the respondents consider to be those who require social and psychological assistance and rehabilitation. In the second stage, a modification of the method of E. S. Bogardus has been applied in order to determine social distance. Teachers and parents believe that children with disabilities need rehabilitation, involvement in an inclusive school community and increased attention. Regarding the categories with other health disorders (ADHD and dysgraphia), the viewpoint of teachers is quite unanimous ‒ they know about these students and believe that they need above average teachers’ attention. However, while parents are aware of the presence of children with ADHD, they are almost unfamiliar with children with reading and writing disorders. Children with mental disorders, autism and ADHD have the greatest problems with integration into inclusive communities. They are ready to be perceived at the maximum social distance ‒ in a special school, in a boarding school, except sporadically on the playground. For employees of the employment service, the maximum social distance was for people with mental and psychological disorders. According to experts’ viewpoints, employers do not want to hire people with these disorders.
An Analysis of the South-South Conflict Issues for Sustainable North Korea Policy
Authors:   Public Policy Research Institute, Korea University, Hong Sukhoon
Published: July 2022

Since the beginning of this year, North Korea's numerous military provocations, including the test-fire of hypersonic missiles, appear to be aimed at maximizing North Korea's nuclear missile reinforcement strategy. In addition, as the ROK and US intelligence agencies have recently determined that North Korea has completed preparations for its 7th nuclear test. Therefore, uncertainty in the situation on the Korean Peninsula is growing. In order to create and promote a sustainable policy toward North Korea, consultation and agreement on North Korea policy within our society is very important.
This paper tries to be premised on the importance of social interest and public consensus on the integration and reunification of the Korean Peninsula. As the inter-Korean conflict is regarded as one of the most serious conflicts in our society, I would like to discuss the issues and solutions of the inter-Korean conflict to create a domestic basis for unification and promote a sustainable North Korea policy, and furthermore to discuss preparations for unification of the Korean Peninsula.
THE WORK OF THE CHELYABINSK REGIONAL CHILDREN'S CLINICAL HOSPITAL IN THE CONTEXT OF THE SPREAD OF A NEW CORONAVIRUS INFECTION COVID-19 IN 2020
Authors: Огошков П.А. , Ласкина Д.А. , Глубоковских С.В.
Published: July 2022

В данной статье представлен опыт работы ГБУЗ «Челябинская областная детская клиническая больница» (ГБУЗ ЧОДКБ)в условиях распространения новой коронавирусной инфекции в 2020 году. Описываются инструменты системы менеджмента качества, которые используются для предотвращения заносов и распространения новой коронавирусной инфекции среди пациентов (сопровождающих/ухаживающих лиц) на амбулаторном приеме и во время стационарного лечения.
VACCINATIONS OF CHILDREN IN REFLECTION OF COLLECTING MEDIA
Authors: Бугаевский К.А. , Пешикова М.В. , Пешиков О.В.
Published: July 2022

В статье представлены результаты исследования, посвящённые отражению в ряде средств коллекционирования – филателии, нумизматике и фалеристике, сведений, касающихся вопроса вакцинации детей. Сведения о вакцинах, процессе вакцинации, об истории вакцинации и ряде учёных, создавших вакцины, представлена на почтовых марках, почтовых конвертах, блоках, картмаксимумах, значках и памятных медалях. Текстовой материал исследования богато проиллюстрирован скриншотами филателистических, фалеристических и нумизматических материалов.
CHARACTERISTICS OF THE COURSE OF NEW CORONAVIRAL INFECTION IN CHILDREN LIVING IN CHELYABINSK AND THE HEALTH STATE OF CHILDREN DURING 6 MONTHS AFTER THE TRANSFERRED SARS-COV-2 INFECTION
Authors: Хамитова Л.И. , Серебрякова Е.Н.
Published: July 2022

В статье представлены особенности течения SARS-CoV-2 (COVID - 19) у 52 детей, проживающих на территории Челябинской области, показано, что в исследуемой группе преобладали мальчики, самой распространенной возрастной группой были дети младшего школьного возраста, самыми частыми клиническими проявлениями SARS-Cov-2 у детей были лихорадка, ринит, слабость/вялость. Легкая форма SARS-Cov-2 зарегистрирована у 39 детей, среднетяжелая (по критерию уровня лихорадки) у 5 детей, бессимптомная форма SARS-Cov-2 установлена у 8 детей.Проанализированы особенности лечения SARS-Cov-2 у детей в группе, и изучено состояние здоровья детей в течение 6 месяцев после перенесенной инфекции SARS-Cov-2, выявлен астенический синдром у 13 детей со средней длительностью 1-2 месяца.
HIPERLIPIDEMIA EM CÃES ATENDIDOS NO HOSPITAL VETERINÁRIO SÃO JUDAS E SUA CORRESPONDÊNCIA COM A OBESIDADE: ESTUDO RETROSPECTIVO DE 2018 A 2020.
Authors: De Oliveira Navarro Thais , Rodrigues Ambrósio Simone , Aparecida Feijó de Souza Vanessa , Rodrigues Soares Milena
Published: July 2022

Atualmente, o estilo de vida antropomorfizado dos animais contribui para o intenso desenvolvimento da obesidade. A hiperlipidemia se apresenta como um dos efeitos deletérios do excesso de peso sobre a saúde dos cães, porém sendo pouco investigada. O termo hiperlipidemia refere-se ao aumento da concentração de lipídeos (colesterol, triglicérides ou ambos) séricos.  Este estudo teve como objetivo realizar uma análise retrospectiva e estatística em animais que foram considerados obesos mediante inspeção de condição de escore corporal,visando correlacionar a obesidade com a presença de hiperlipidemias. Foram revisadas e analisadas 70 amostras sanguíneas de pacientes atendidos no Hospital Veterinário São Judas de outubro de 2018 a outubro de 2020 que já haviam realizado análises bioquímicas no Hospital; foram retiradas as informações destinadas a exames bioquímicos de triglicérides, colesterol e peso juntamente com a avaliação de condição de escore corporal (ECC) que foi feita em consulta clínica. Constatou-se que 24 (34,2%) amostras apresentaram resultados acima dos valores de referência para colesterol e triglicérides. Dentre esses 24 cães, 21 (87,5%) apresentaram ECC igual 7 ou maior, representando sobrepeso e/ou obesidade. Nenhum dos cães havia comparecido para atendimento pelo mesmo motivo e não houve queixa dos tutores tratando-se de sobrepeso, portanto, as alterações encontradas em exames bioquímicos foram um achado clínico laboratorial. Dos 21 cães componentes do grupo que apresentaram distúrbios metabólicos, 12 cães (57,2%) apresentaram ambos os valores de triglicérides e colesterol aumentados, apresentando então uma hiperlipidemia; 5 (23,8%) cães apresentaram hipercolesterolemia e 4 (19%) apresentaram hipertrigliricedemia. Essas alterações quando comparadas com um grupo controle de 19 animais sem alterações dignas de nota, revelaram valores de significância estatística, sugerindo alta frequência de hiperlipidemia em cães obesos, classificada como moderadamente elevados com importância clínica, havendo prevalência nas fêmeas.
INFECÇÃO ESPÚRIA POR Capillaria hepatica EM CANINO DOMÉSTICO, RELATO DE CASO
Authors: Ferraz Alexsander , Moura de Lima Camila , Da Fonseca Sapin Carolina , Tavares Barwaldt Eugênia , Angonesi de Castro Tanize , De Oliveira Nobre Márcia , Quintana Nizoli Leandro
Published: July 2022

Capillaria hepatica é um nematódeo hepatotrópico da família Capillariidae, que acomete principalmente roedores, os quais são considerados reservatórios, podendo infectar também, com menor frequência, cães, gatos e o homem, pois possui potencial zoonótico, sendo responsável pela capilariose hepática. A infecção verdadeira ocorre através da ingestão de ovos embrionados infectantes liberados do fígado, após morte e decomposição do hospedeiro, por canibalismo ou por predação. A infecção espúria acorre através da ingestão de ovos não embrionados, encontrados no solo ou pela ingestão de fígado de mamíferos infectados com C. Hepatica, causando um quadro de pseudoparasitismo. Os sinais clínicos nos animais acometidos pela infecção verdadeira, podem ser inespecíficos ou associados a doença hepática como, vômito, diarreia, dor abdominal, icterícia e encefalopatias. O objetivo deste trabalho foi relatar um caso de infecção espúria por C. hepatica em canino doméstico, no município de Pelotas, Rio Grande do Sul, Brasil, diagnosticado a partir da observação de ovos do parasito em exame coproparasitológico.
Salud mental y calidad de vida en población ecuatoriana expuesta a la pandemia covid-19, año 2022
Authors: Nacimba Quinga Cynthia Alexandra , Ramírez Lema Katheryn Aracely , Roncancio Rubiano Maria Camila , Soria Pazmiño Johanna Carolina
Published: July 2022

La Organización Mundial de la Salud (2020) se ha pronunciado sobre las consecuencias psicosociales y de salud en la población mundial, a causa del SARS-CoV-2. El presente trabajo de investigación tiene como objetivo valorar el impacto de la exposición a la pandemia de covid-19, en la salud mental y calidad de vida de la población ecuatoriana durante el año 2022.  La metodología aplicada consistió en una investigación cualitativa con alcance descriptivo haciendo uso de la escala Dass y escala Whoqol con una muestra de 518 personas ecuatorianas. El 35,3% de los participantes se infectaron de covid-19, de los encuestados 51,4% son solteros, un 0,6% de encuestados no escolarizados frente a 75,5% de personas con educación superior y un 86,1% de personas con estrato económico. Este estudio establece una línea de investigación centrada en describir cómo la covid-19 ha impactado en la salud mental y calidad de vida en las personas ecuatorianas. El estrés y la ansiedad fueron presentados por trabajadores, estudiantes con nivel de estudios básicos (4.8%), medio (19.1%), superior (75.5%) y no escolarizados un 0.6%. De ellos el 47,0% mostró alteración en los niveles de estrés, siendo este factor el más notorio en cuanto a las afectaciones producidas.
Estrés percibido y calidad de vida en la población ecuatoriana expuesta a la pandemia por la covid – 19
Authors: Andrade Gaibor Elizabeth Malena , Secaira Vaca María Cristina , Sánchez Pachacama Diana Patricia , Mena Tovar Mariuxi Alexandra
Published: July 2022

En la actualidad, el mundo se ha visto afectado por consecuencia de la pandemia de la covid – 19, razón por la cual fue declarada como emergencia de salud pública de interés internacional por el Comité de Emergencias del Reglamento Sanitario Internacional, en este sentido, se establece como objetivo principal evaluar el nivel de estrés percibido y calidad de vida en población ecuatoriana expuesta a la pandemia por la Covid – 19, año 2021. El presente trabajo tiene una metodología de estudio cuali-cuantitativo y el diseño es no experimental. Tiene un alcance exploratorio descriptivo y se aplicó una encuesta online a 85 personas mayores de edad, quienes dieron su consentimiento informado para la aplicación. El 38.1% de los encuestados fueron infectados de covid 19, mientras que el 61.9% no se infectó. La mayoría de participantes reportaron niveles leves de estrés percibido por SARS-CoV-2, respecto al índice la calidad de vida, de los participantes mostraron niveles gratificantes en cuanto al dominio de la salud física, relaciones sociales y afectivos relacionados al entorno. Predominando la salud mental, se observó indicadores altos de sintomatología clínica, asociado a ansiedad, estrés, depresión. En general, se encontraron niveles entre bajos y moderados de estrés percibido que afecta la calidad de vida del personal que labora en el ámbito educativo ecuatoriano expuesto a la pandemia por la Covid – 19.
Café-Relevant Value and Brand Awareness on Purchase Intention: Empirical Study of Local Brand Cafe
Authors: Panjaitan Roymon , Zusrony Edwin
Published: July 2022

The importance of this study is discussed to determine the intensity of purchases resulting from cafe-relevant value, as well as the impact of brand awareness through e-wom. Two hundred forty-six respondents were used as coffee lovers in cafes, most used questionnaires and interviews as data collection methodologies. This study analyzed data from e-WOM-mediated path analysis on purchase intention using SEM-PLS multiple path analysis. The research findings have a positive relationship between cafe relevant value and brand awareness in influencing e-wom and a direct positive contribution between café-relevant value and brand awareness on purchase intention. So, it is proven that e-wom has the potential to increase the intensity of coffee purchases in cafes.
INNOVATION, ENTREPRENEURSHIP ORIENTATION, UTILIZATION OF E-COMMERCE, AND INTELLECTUAL CAPITAL ON MSME PERFORMANCE IN THE COVID-19 PANDEMIC
Authors: Afrinaldi Muhammad , Basri Yesi Mutia , Rafiq Aunnur
Published: July 2022

This study aims to analyze the effect of innovation, entrepreneurial orientation, utilization of e-commerce, and intellectual capital on the performance of MSMEs during the COVID-19 pandemic in Pekanbaru City. The data used in this study is primary data, with a questionnaire as an instrument. The method used for sample selection is the non-probability sampling technique. In this study, the total MSMEs in Pekanbaru City affected by COVID-19 was 7888. The research sample was 100 MSMEs. The data analysis technique used in this study is multiple linear regression analysis using Statistical Product and Service Solution (SPSS) data processing software version 26.0. The results show that only innovation, entrepreneurial orientation, and utilization of e-commerce affect MSMEs performance.  This research has contributed to MSMEs improving their performance during the COVID-19 pandemic.
Incidencia de cáncer de mama según tipo histológico e inmunohistoquímico en el Hospital Augusto Hernández Mendoza - Ica. Periodo 2013-2017.
Authors: Palomino-Anyarin Belen Eunise , Brizuela-Pow San Nancy
Published: July 2022

Objetivo: Determinar la incidencia de cáncer de mama según tipo histológico e inmunohistoquímico en el Hospital Augusto Hernández Mendoza - Ica. Periodo 2013 - 2017. Material y método: Investigación cuantitativa, observacional, transversal y retrospectiva. Se utilizó a todas las mujeres diagnosticadas con cáncer de mama (n=224) en el Hospital Augusto Hernández Mendoza, EsSalud, Ica entre los años 2013- 2017. Resultados: De las participantes 210 mujeres (94%) presentó el tipo histológico Carcinoma ductal infiltrante, 5 pacientes (2%) la variedad de Carcinoma ductal in situ y 9 pacientes (4%) la variedad de carcinoma lobulillar infiltrante. El 62% de pacientes con cáncer de mama presentó variante inmunohistoquimico Luminal A, 19% cáncer de mama tipo Luminal B, 8% cáncer triple negativo y el 11% presentó la variante Her2 positivo. Conclusiones: Se determinó que el nivel de incidencia de cáncer de mama es elevado; el tipo de cáncer de mama más frecuente es de tipo histológico carcinoma ductal infiltrante.
Evaluación de procedimientos de salvataje y amputación mayor del miembro inferior por pie diabético en Hospital MINSA Ica. 2010 – 2014.
Authors: Angulo-Flores Javier , Flores-Hernández Oriele , Paccori-Rodrigo Yhony , Flores-Quispe Pablo , Angulo-Flores Zaida
Published: July 2022

Objetivo: Evaluar procedimientos de salvataje y amputación mayor del miembro inferior por pie diabético complicado en Hospital Regional Ica, enero 2010 a diciembre 2014. Materiales y métodos: Se realiza estudio descriptivo, retrospectivo, de revisión datos. Se evaluó edad, sexo, estudio doppler vascular, índice de isquemia, grado de infección, revascularización de extremidad, uso de oxigenación hiperbárica a las heridas complicadas del pie, previo a la amputación. Se realiza medidas descriptivas y cuantitativas (frecuencias, promedio, desvío estándar) y en estudio de asociación test Chi-cuadrado y Correlación R Pearson. Resultados: Se estudiaron 58 amputaciones en 50 pacientes, re-amputaciones 7 en el otro miembro, 1 más en él mismo. Promedio edad 69. 48años ± 10. 691. Sexo 28 (56, 0%) masculino, 22 (44,0%) femenino. Ulcera Infectada: profunda + infección + osteomielitis 13 (26,0%), gangrena necrotizante 33 (66,0%), gangrena extensa 1 (2,0%), gangrena Seca 3 (6,0%). infecciones graves 7 (14,0%), infecciones que amenazan la vida 27 (54,0%), necesidad de valorar isquemia 14 (28,0%), ninguna 2 (4,0%). Educación en cuidado de pies: pobre 15(30,0%), ninguna 35 (70,0%). dato de revascularización arterial 1(2,0%), oxigenación hiperbárica 3(6,0%), ninguno (92,0%). Enfermedad Vascular Periférica: arterioesclerosis a predominio Izquierdo 29 (58,0%), a predominio derecho 10 (20,0%), no arterioesclerosis 5 (10,0%), no estudio Doppler 6 (12,0%). Conclusiones: La gangrena necrotizante, infecciones que amenazan la vida; pobre educación en el cuidado de los pies; la pobre utilización de medidas de salvataje se asocia a amputaciones y re-amputaciones mayores del miembro inferior por pie diabético.
HEALTH CARE IN COVID-19 ENVIRONMENT: QUALITY ASSESSMENT OF MEDICAL VENTILATORS BY HEALTH CARE SYSTEM ENTITIES
Authors: Antonova N.L. , Smirnova O.G.
Published: July 2022

The purpose of this article is to comprehend the functioning of the institute of public health in a pandemic and to conduct a research analysis of the opinions and judgments of medical workers and patients using medical ventilation devices. The national health care system faces a global challenge associated with the spread of COVID-19, which has exposed problem areas in its functioning, one of which is the quality and reliability of medical equipment. Medical ventilators are of vital importance, because their availability and quality determine the recovery of patients and their return to a familiar way of life. Ventilators are used in intensive care units and wards for treatment of severe complications of coronavirus infection. The main subjects of the health care system were interviewed using the semi-formalized interview method: doctors (n = 32) and patients (n = 16). The survey results showed that the quality of Russian devices requires significant improvement (oxygen tubes and flow sensors), and the main measures to improve the quality of medical care using ventilators are not only buying of imported medical equipment, but also strengthening quality control of domestic devices and creating real competitive environment of Russian manufacturers. In the context of the "new normalcy" on the Russian market of ventilators, it’s possible to transit from an import-oriented model to a national-state model with a significant proportion of medical products manufactured by Russian companies.