bluuebunny/crossref_metadata_2025 huggingface dataset:
Сравнение эффективности и акушерских исходов различных методов подготовки эндометрия к переносу размороженных эмбрионов в естественном цикле и на фоне заместительной гормональной терапии
Authors: Савина Валентина , Исакова Э.В. , Самойлович Я.А. , Корсак В.С.
Published: April 2022

Актуальность: Увеличение частоты применения метода переноса размороженных эмбрионов (РЭ) в рамках вспомогательных репродуктивных технологий (ВРТ) делает актуальным изучение эффективности и анализ акушерских исходов различных методов подготовки эндометрия в таких циклах.
Цель исследования – определение оптимального метода подготовки эндометрия к программе РЭ.
Методы: Проанализирована эффективность подготовки эндометрия в циклах РЭ в естественном цикле (Группа 1, n=124) и на фоне заместительной гормональной терапии (ЗГТ) (Группа 2, n=120) у пациенток в возрасте 22-40 лет с бесплодием. Оценены следующие параметры: толщина эндометрия в день РЭ, частота наступления клинической беременности (ЧНБ), самопроизвольный выкидыш при сроке до 12 недель гестации, угрожающий выкидыш в I триместре беременности, гестационный сахарный диабет (ГСД), истмико-цервикальная недостаточность (ИЦН), гипертензивные расстройства в III триместре беременности, предлежание плаценты, общая прибавка веса, срок и способ родоразрешения, вес детей при рождении, частота родов живым плодом.
Результаты: Толщина эндометрия в день РЭ в группах исследования значимо не различалась (р=0,52). ЧНБ была выше при применении ЗГТ по сравнению с РЭ в ЕЦ (61,6% и 51,6% соответственно), однако различия не были статистически значимыми (р=0,057). В группе ЗГТ достоверно чаще регистрировался самопроизвольный выкидыш до срока 12 недель беременности (р=0,0096), а также гипертензивные расстройства в третьем триместре беременности (р=0,0097).  
Группы значимо не отличались по частоте угрожающего выкидышу (р=0,17) и ГСД (р=0,26), ИЦН (р=0,07), предлежанию плаценты (р=0,38), общей прибавке веса (р=0,35), сроку и способу родоразрешения (р=0,35 и 0,27, соответственно), весу детей при рождении (p=0,66 при родах одним ребенком, p=0,902 при родах двойней), частоте родов живым плодом (р=0,942).
Заключение: Результаты исследования не показали преимуществ какого-либо метода подготовки эндометрия к РЭ в плане ЧНБ. Однако, учитывая полученные данные о повышенном риске невынашивания беременности и гестоза при ЗГТ, следует применять индивидуальный подход при выборе наиболее оптимального метода подготовки эндометрия, не только обеспечивающего высокую ЧНБ, но и способствующего росту благоприятных исходов программ ВРТ.
A rendőrtiszthelyettes-képzés múltja és jelene
Authors: Lippai Zsolt
Published: April 2022

Aim: Citizens will first and foremost have direct day-to-day contact with the officers who form the imaginary backbone of policing. This is the case, for example, with a roadside check, a police stop or any other ‘everyday’ police action, where the legislator and all members of society expect our police officers to make sound, human and professional decisions. In taking action, the police must make necessary, proportionate, legal and professional decisions, one of the essential prerequisites of which is an appropriate level of basic training, continuous training and further training, and the continuous development of knowledge. The aim of this study is to present the past and present of the training of police officers, which is little known to many.Methodology: For the preparation of the study, in addition to examining the available relevant domestic literature, the practical aspects of today’s officer training will be discussed.Findings: The police profession is a highly responsible service requiring specialised knowledge and skills, and the training programmes and institutions that provide the foundations for this have evolved and continue to evolve with the expectations placed on police forces throughout their history, which has been full of trials and challenges.Value: The study presents the past and present of the little-known training of domestic police officers.
Szövegbányászat a dark neten: rendészettudományi alkalmazások
Authors: Szigeti Ákos
Published: April 2022

Aim: The users of cyberspace create an enormous amount of textual data on the surface web and on the deep web as well, including the anonymity based darknet platforms. The various automated analytical methods of text mining allow us to analyse these big data sources, which opportunity is already exploited by several researchers. The aim of my study was to review the use cases which are relevant from the aspect law enforcement studies.Methodology: As text mining is relatively new in social sciences, I applied state-of-the-art review methodology, which is specialized in reviewing current literature to offer new perspectives in a field of research.Findings: In the international literature, we can find examples for classifying legal and illegal content by statistical language models, strengthening the theory of darknet’s dual-usage. Darknet markets usually end up being closed by law enforcement agencies, just like it happened in the case of the Silk Road market, back in 2013. Analysing the trends of user activity after the closure of specific darknet markets can help in evaluating the interventions of law enforcement.Value: By presenting these examples, this study shed light on the exploitable opportunities of text mining as a research method in law enforcement studies.
The Open Cluster Chemical Abundances and Mapping Survey. VII. APOGEE DR17 [C/N]–Age Calibration
Authors: Spoo Taylor , Tayar Jamie , Frinchaboy Peter M. , Cunha Katia , Myers Natalie , Donor John , Majewski Steven R. , Bizyaev Dmitry , García-Hernández D. A. , Jönsson Henrik , Lane Richard R. , Pan Kaike , Longa-Peña Penélope , Roman-Lopes A.
Published: April 2022

Large-scale surveys open the possibility to investigate Galactic evolution both chemically and kinematically; however, reliable stellar ages remain a major challenge. Detailed chemical information provided by high-resolution spectroscopic surveys of the stars in clusters can be used as a means to calibrate recently developed chemical tools for age-dating field stars. Using data from the Open Cluster Abundances and Mapping survey, based on the Sloan Digital Sky Survey/Apache Point Observatory Galactic Evolution Experiment 2 survey, we derive a new empirical relationship between open cluster stellar ages and the carbon-to-nitrogen ([C/N]) abundance ratios for evolved stars, primarily those on the red giant branch. With this calibration, [C/N] can be used as a chemical clock for evolved field stars to investigate the formation and evolution of different parts of our Galaxy. We explore how mixing effects at different stellar evolutionary phases, like the red clump, affect the derived calibration. We have established the [C/N]–age calibration for APOGEE Data Release 17 (DR17) giant star abundances to be

log

[
Age
(
yr
)
]

DR
17

=
10.14

(
±
0.08
)
+
2.23
(
±
0.19
)

[
C

/

N
]

, usable for

8.62
≤
log
(
Age
[
yr
]
)
≤
9.82

, derived from a uniform sample of 49 clusters observed as part of APOGEE DR17 applicable primarily to metal-rich, thin- and thick-disk giant stars. This measured [C/N]–age APOGEE DR17 calibration is also shown to be consistent with asteroseismic ages derived from Kepler photometry.
Kepler-1656b’s Extreme Eccentricity: Signature of a Gentle Giant
Authors: Angelo Isabel , Naoz Smadar , Petigura Erik , MacDougall Mason , Stephan Alexander P. , Isaacson Howard , Howard Andrew W.
Published: April 2022

Highly eccentric orbits are one of the major surprises of exoplanets relative to the solar system and indicate rich and tumultuous dynamical histories. One system of particular interest is Kepler-1656, which hosts a sub-Jovian planet with an eccentricity of 0.8. Sufficiently eccentric orbits will shrink in the semimajor axis due to tidal dissipation of orbital energy during periastron passage. Here our goal was to assess whether Kepler-1656b is currently undergoing such high-eccentricity migration, and to further understand the system’s origins and architecture. We confirm a second planet in the system with M
c = 0.40 ± 0.09 M
jup and Pc = 1919 ± 27 days. We simulated the dynamical evolution of planet b in the presence of planet c and find a variety of possible outcomes for the system, such as tidal migration and engulfment. The system is consistent with an in situ dynamical origin of planet b followed by subsequent eccentric Kozai–Lidov perturbations that excite Kepler-1656b’s eccentricity gently, i.e., without initiating tidal migration. Thus, despite its high eccentricity, we find no evidence that planet b is or has migrated through the high-eccentricity channel. Finally, we predict the outer orbit to be mutually inclined in a nearly perpendicular configuration with respect to the inner planet orbit based on the outcomes of our simulations and make observable predictions for the inner planet’s spin–orbit angle. Our methodology can be applied to other eccentric or tidally locked planets to constrain their origins, orbital configurations, and properties of a potential companion.
Qui dirige les administrations du triangle institutionnel et des agences ?
Authors: Bordier Sophia , Georgakakis Didier
Published: April 2022

Cet article porte sur une analyse statistique des directeurs et directrices de l’administration du triangle institutionnel européen et des agences. Quels sont les profils des directeurs et directrices, en quoi diffèrent-ils et que nous disent-ils plus largement des structures sociologiques du pouvoir administratif au sein des institutions de l’Union européenne ? Pour le comprendre, l’article analyse le profil de 95 directeurs d’administration européenne au prisme de différentes variables socio-biographiques (âge, sexe, nationalité) et liées aux types de carrières et à la formation. On procède enfin à une analyse par correspondance multiple pour construire la cartographie de cette fraction administrative du champ de l’eurocratie.
Y a-t-il un pilote dans la gestion des crises ? Attentes et enjeux de cohérence dans les interventions européennes extérieures
Authors: Buchet de Neuilly Yves
Published: April 2022

À travers l’exemple de la gestion européenne des crises en République centrafricaine, cet article vise à saisir les enjeux plus généraux de la division du travail de gestion de crise et de l’articulation entre acteurs intervenant dans une pluralité de secteurs des relations internationales (diplomatie politique, sécurité collective, développement, aide humanitaire) mis en tension par les attentes de coordination, de cohérence, d’approche intégrée. L’article montre ainsi que les gestionnaires de crises sont pris dans des dynamiques de coopération concurrentielle pour le contrôle et l’allocation de ressources publiques. La labellisation d’une situation comme « crise » ouvre des habilitations, des opportunités d’actions et de revendications, tout en soulevant potentiellement d’intenses enjeux de coordination.
Le rapport annuel d’activité et le cycle de programmation : les transformations administratives de l’UE au prisme des instruments de la réforme Kinnock
Authors: Barbot Maëlle
Published: April 2022

Le volet planification stratégique et programmation de la réforme Kinnock a induit de nombreux changements sur les pratiques et la culture de la Commission. Les instruments de gestion introduits par cette réforme permettent d’aborder le processus de centralisation, les relations administratives et l’importance des contrôles. Elle permet de comprendre l’évolution des paradigmes et de la culture de la Commission européenne ainsi que les liens entretenus entre la gestion et le politique.
Space-time statistics of a linear dynamical energy cascade model
Authors: Apolinário Gabriel B. , Chevillard Laurent
Published: April 2022

A linear dynamical model for the development of the turbulent energy cascade was introduced in Apolinário et al. (J. Stat. Phys., 186, 15 (2022)). This partial differential equation, randomly stirred by a forcing term which is smooth in space and delta-correlated in time, was shown to converge at infinite time towards a state of finite variance, without the aid of viscosity. Furthermore, the spatial profile of its solution gets rough, with the same regularity as a fractional Gaussian field. We here focus on the temporal behavior and derive explicit asymptotic predictions for the correlation function in time of this solution and observe that their regularity is not influenced by the spatial regularity of the problem, only by the correlation in time of the stirring contribution. We also show that the correlation in time of the solution depends on the position, contrary to its correlation in space at fixed times. We then investigate the influence of a forcing which is correlated in time on the spatial and time statistics of this equation. In this situation, while for small correlation times the homogeneous spatial statistics of the white-in-time case are recovered, for large correlation times homogeneity is broken, and a concentration around the origin of the system is observed in the velocity profiles. In other words, this fractional velocity field is a representation in one-dimension, through a linear dynamical model, of the self-similar velocity fields proposed by Kolmogorov in 1941, but only at fixed times, for a delta-correlated forcing, in which case the spatial statistics is homogeneous and rough, as expected of a turbulent velocity field. The regularity in time of turbulence, however, is not captured by this model.
The Effects of Quantitative Easing on Income Inequality in Japan
Authors: Leo David
Published: April 2022

This paper examines the effects of quantitative easing on income inequality in Japan
Asymmetric Efect of Fluctuating Oil Prices on Remittance Infows to the Philippines
Authors: Levy Shir
Published: April 2022

This paper analyzes the efect of crude oil prices on remittance infows to the Philippines from Gulf Cooperation Council (GCC) countries.
Immunohistochemical expression and clinicopathological assessment of PD-1, PD-L1, NY-ESO-1, and MAGE-A4 expression in highly aggressive soft tissue sarcomas
Authors: Hashimoto Kazuhiko , Nishimura Shunji , Ito Tomohiko , Kakinoki Ryosuke , Akagi Masao
Published: April 2022

Immunotherapy has altered the treatment paradigm for soft tissue sarcomas (STSs). Considering the limited information regarding the clinical significance of immunohistochemical markers in STS, the purpose of this study was to determine the clinical significance of programmed cell death-1 (PD-1), PD ligand-1 (PD-L1), New York esophageal squamous cell carcinoma-1 (NY-ESO-1), and melanoma-associated antigen-A4 (MAGE-A4) expression in STSs. Twenty-two patients (median age, 72.5 years) with STSs treated at our hospital were included in this study. The specimens obtained at the time of biopsy were used to perform immunostaining for PD-1, PD-L1, NY-ESO, and MAGE-A4. The rates of PD-1-, PD-L1-, NY-ESO-, and MAGE-A4-positive cells and cases were calculated. The correlations among the positive cell rates of the immunohistochemical markers as well as their correlations with the histological grade, tumor size, or maximum standardized uptake (SUVmax) value were also determined. The average rates of PD-1-, PD-L1-, NY-ESO-, and MAGE-A4-positive cells were 4.39%, 28.0%, 18.2%, and 39.4%, respectively. Although the PD-1-positive cell rate showed no correlation with the rates of NY-ESO-1- and MAGE-A4-positive cells, the PD-L1-positive cell rates showed strong positive correlations with the rates of NY-ESO-1- and MAGE-A4-positive cells. PD-1-, PD-L1-, NY-ESO-1-, and MAGE-A4-positive cell rates showed weak to moderate correlations with histological grade or tumor size, while the PD-1-, PD-L1-, and MAGE-A4-positive cell rates showed strong to very strong positive correlations with the SUVmax value. Thus, PD-1, PD-L1, NY-ESO, and MAGE-A4 expressions are correlated and may be involved in the aggressive elements of STSs.
Can we omit systematic biopsies in patients undergoing MRI fusion-targeted prostate biopsies?
Authors: Leow Jeffrey J , Koh Soon Hock , Chow Marcus WL , Loke Wayren , Rolando Salada II , Hong Seok Kwan , Yeow Yuyi , Lee Chau Hung , Tan Cher Heng , Tan Teck Wei
Published: April 2022

Magnetic resonance imaging (MRI)-targeted prostate biopsy is the recommended investigation in men with suspicious lesion(s) on MRI. The role of concurrent systematic in addition to targeted biopsies is currently unclear. Using our prospectively maintained database, we identified men with at least one Prostate Imaging-Reporting and Data System (PI-RADS) ≥3 lesion who underwent targeted and/or systematic biopsies from May 2016 to May 2020. Clinically significant prostate cancer (csPCa) was defined as any Gleason grade group ≥2 cancer. Of 545 patients who underwent MRI fusion-targeted biopsy, 222 (40.7%) were biopsy naïve, 247 (45.3%) had previous prostate biopsy(s), and 76 (13.9%) had known prostate cancer undergoing active surveillance. Prostate cancer was more commonly found in biopsy-naïve men (63.5%) and those on active surveillance (68.4%) compared to those who had previous biopsies (35.2%; both P < 0.001). Systematic biopsies provided an incremental 10.4% detection of csPCa among biopsy-naïve patients, versus an incremental 2.4% among those who had prior negative biopsies. Multivariable regression found age (odds ratio [OR] = 1.03, P = 0.03), prostate-specific antigen (PSA) density ≥0.15 ng ml−2 (OR = 3.24, P < 0.001), prostate health index (PHI) ≥35 (OR = 2.43, P = 0.006), higher PI-RADS score (vs PI-RADS 3; OR = 4.59 for PI-RADS 4, and OR = 9.91 for PI-RADS 5; both P < 0.001) and target lesion volume-to-prostate volume ratio ≥0.10 (OR = 5.26, P = 0.013) were significantly associated with csPCa detection on targeted biopsy. In conclusion, for men undergoing MRI fusion-targeted prostate biopsies, systematic biopsies should not be omitted given its incremental value to targeted biopsies alone. The factors such as PSA density ≥0.15 ng ml−2, PHI ≥35, higher PI-RADS score, and target lesion volume-to-prostate volume ratio ≥0.10 can help identify men at higher risk of csPCa.
Training and certification of EUS operators in China
Authors: Hou Xun , Liang Jinyu , Konge Lars , Hu Wenjie
Published: April 2022

Background and Objectives:

EUS has become a very frequently used procedure for both diagnostic and therapeutic indications. However, skilled operators are essential for improved outcomes and patient safety which make efficient training and certification programs essential. Our aim was to explore the acquisition and assessment of EUS competencies in China as practiced in the past, today, and in the future.

Methods:

We identified key opinion leaders (KOLs) from hospitals in different cities in China. Each KOL answered 43 questions regarding demographics and EUS experience, their learning experience as a trainee, experience as a supervisor, and their thoughts about current and future training. Descriptive statistics were used for reporting the results.

Results:

Eleven men and five females from eight major Chinese cities (Beijing, Changsha, Chengdu, Chongqing, Guangzhou, Shanghai, Shenzhen, and Wuhan) were included. They offered a good variance regarding age (33–53 years old), EUS experience (½–20 years), and performed procedures (20–6000 procedures). Most (n = 13) learned EUS through apprenticeship training model but three were self-taught. The KOLs also used the apprenticeship model to train their own trainees. First, they demonstrated EUS for median 2 months before their trainees took over the scope and performed a median 50 supervised procedures during a median of 3 months. Then they were allowed to perform EUS procedures independently. Simulation-based training and standardized assessment of competence were used very sparingly, but most of the KOLs wanted to shift towards these contemporary methods in the future.

Conclusions:

The classical apprenticeship training is still used to learn EUS in China and the amount of training required before being allowed to practice independently varies considerably. Several of the KOLs requested improved conditions for training and wanted a standardized curriculum leading to certification of new EUS operators based on a valid assessment of competence.
Temporal Bone Rhabdomyosarcoma Mimicking Chronic Suppurative Otitis Media
Authors: Shah Isha , Malukar Siddharth , Singh Jayesh , Parikh Ankita , Kunikullaya U. Suryanarayana
Published: April 2022

Rhabdomyosarcoma (RMS) is one of the most commonly encountered soft-tissue sarcomas in childhood. The most common location is in the head-and-neck region, followed by the urogenital system, extremities, and torso. Head and neck is a common site though the temporal bone is an extremely rare site with only a few reported cases in the literature till now. Herein, we report a case of a sclerosing type of temporal bone RMS in an 8-year-old young girl. We discuss clinical, pathological, radiological findings and management of temporal bone RMS. Misdiagnosis is common because of this aggressive temporal bone lesion's similarity to more common benign diseases. Clinicians should maintain suspicion for RMS in patients with chronic otitis media not responsive to medical therapy and should refer a specialist multidisciplinary team in a timely manner as an early diagnosis will optimize the chance of survival. Clinical features, radiologic findings, and histopathological examination using immunohistochemistry are all important for the correct diagnosis of temporal bone RMS. It is important to be aware of and to know how to deal with such rare cases.
Comparison Between Autologous and Artificial Graft Ossiculoplasty in Canal Wall Down Tympanomastoidectomy
Authors: Tawalbeh Mohamed , Khreesha Lubna , Ali Elnagi , Al Nsour Ahmad , Shatnawi Jareer , Al-Shudifat Abdulrahman
Published: April 2022

Background:

Ossiculoplasty is the reconstruction of ossicular chain: Malleus, incus, and stapes. This procedure attempts to reestablish the continuity between the tympanic membrane and the oval window. Different materials were used in ossiculoplasty; whether to use autologous grafts or synthetic prosthesis.

Aims:

This study aimed to evaluate hearing changes in patients' undergone ossiculoplasty as a part of Tympanomastoidectomy. Also, to appraise the autologous reconstruction materials used in ossiculoplasty at Jordan University Hospital (JUH) in comparison to other materials.

Materials and Methods:

A retrospective study done for a total of 100 patients underwent ossiculoplasty using autologous and artificial graft during canal wall down tympanomastoidectomy at JUH from 2009 to 2019.

Results:

Overall average mean of air-bone gap (ABG) closure (Hearing Gain) for Group A was 11.07 dB, while for Group B was 7.5 dB; this decrease was found to be highly significant (P = 0.002). In Group A, ABG mean was (34.44 dB) preoperative and reduced to 23.37 dB postoperative, while in Group B was (32.95 dB) preoperative and reduced to 25.45 dB postoperative.

Conclusions:

Autologous grafts can be used safely in reconstruction of middle ear with favorable outcome. Our study is one of the few reports that compare outcome between artificial and autologous graft in ossiculoplasty.
Auditory Neuropathy Spectrum Disorder in Two Siblings with Congenital Cytomegalovirus Infections
Authors: Suwento Ronny , Hajarani Kartika , Zizlavsky Semiramis , Airlangga Tri Juda
Published: April 2022

Auditory neuropathy spectrum disorder (ANSD) is a rare hearing disorder when signal transmission is disrupted on the auditory pathway. Infection is one of the multifactorial causes of ANSD. Only a few researchers have reported the cases of ANSD caused by congenital cytomegalovirus (CMV) infection, and fewer have presented cases involving siblings. In our study, the two patients were siblings, aged 3 years and 7 months and 8 months. They were born prematurely, had microcephaly; anti-CMV IgG levels were reactive. Distortion product otoacoustic emissions test was normal. A click auditory brainstem response showed that no wave was detected with an 80 dB stimulus, and a cochlear microphonic response was obtained. No abnormality in the middle ear was observed, and negative acoustic reflexes were noted. Hearing habilitation with a low-gain hearing aid, speech therapy, and motoric habilitation was planned, and the patients were referred to the pediatric neurology for CMV management.
Speech Recognition, Quality of Hearing, and Data Logging Statistics over Time in Adult Cochlear Implant Users
Authors: Malzanni Giulia Elvira , Lerda Caterina , Battista Rosa Alessia , Canova Chiara , Gatti Omar , Bussi Mario , Piccioni Lucia Oriella
Published: April 2022

Objective:

The objective of this study was to examine improvement in speech recognition and “the Speech, Spatial and Qualities of Hearing Scale” (SSQ) scores in monolateral cochlear implant (CI) users and its correlations to data logging statistics.

Materials and Methods:

A prospective observational, nonrandomized, study was conducted analyzing speech tracking with shielded mouth in noise (SMn), speech audiometry, and SSQ questionnaire (Italian version) at 1, 3, and 6 months postactivation of CI of 31 patients. The overall data of average daily use and acoustic scene analyses were extracted from data logging system. Data of 6-month cumulative speech in quiet-, speech-in-noise-, and noise-listening time of 19 patients were correlated to speech perception scores and SSQ scores.

Results:

An improvement was observed in all outcomes (speech tracking with SMn, speech audiometry, and SSQ scores). Listeners used their device on for a mean time of 13.45 h per day. Quiet scene was the most represented listening environment. A significant positive correlation was found between noise exposition (in hours) and hearing quality score of SSQ and between exposition to 60–69 dB noise and scores resulted from each part of SSQ.

Discussion:

The analysis failed to demonstrate a correlation between auditory performances and both exposition to speech scene and total exposition. However, time spent in noise using the device correlated with SSQ scores.

Conclusion:

Cochlear implantation ensures good results in speech recognition and quality of life, with progressive scores' improvement after activation. A predominant use in quiet was observed together with a correlation between hearing performance and exposition to noise.
Strengthening the Process of Self-directed Learning in Medical Education by Targeting Teachers and Students
Authors: Shrivastava Saurabh RamBihariLal , Shrivastava Prateek Saurabh
Published: April 2022

The range of knowledge and skills expected of a medical student upon completion of their course is vast. There is an immense need to encourage self-directed learning (SDL) among medical students, which in turn will help the medical institutions to attain the core competency of transforming students into lifelong learners. Medical teachers have to play crucial roles and they should be looked upon as one of the sources for skills and not a source of content. The success of SDL depends upon the extent of involvement of the students in the entire process and this has to begin with, being aware of SDL, accepting the fact that SDL is the way to go into the field of medical education and to enable practicing of evidence-based medicine. To conclude, SDL is an effective and vital strategy to expedite learning among medical students. The need of the hour is to give SDL adequate importance and the success of the initiative will eventually depend on the facilitation role of the teacher and the active engagement of the student.
Challenges Encountered by Teachers in Medical Education
Authors: Shrivastava Saurabh RamBihariLal , Shrivastava Prateek Saurabh
Published: April 2022

In general, it is expected from medical teachers that they should transform fresh learners into competent medical graduates upon completion of their training period. However, a lot goes into this, as the delivery of medical education is quite different and complicated in comparison to any other graduate courses available. Teachers play an instrumental role in helping the students acquire various noncognitive attributes essential for successful medical practice. A number of challenges have been identified from the teachers' perspective in medical training. In conclusion, the job profile of medical teachers is extremely demanding as they have to simultaneously perform on various domains. There is an immense need to support the medical teachers in their assigned roles so that their overall outcomes can be significantly enhanced.
Drug Utilization Pattern at the Cardiac Surgical Outpatient Clinic in a Tertiary Care Hospital at Goa
Authors: Kolwalkar Jagannath , Jose Dhanya , Borkar Shirish , Madhan Vijay , Rataboli P V , Cacodcar Jagdish A. , Dhupdale Nitin Y.
Published: April 2022

Background:

Drug utilization research encourages rational drug prescribing practices and thus contributes to the contemporary use of drugs in the society. This study assesses the drug utilization pattern (DUP) at the cardiac surgical outpatient department of Goa Medical College hospital. We used the World Health Organization (WHO)-prescribing indicators to analyze the National List of Essential Medicines (NLEM) implementation as recommended in the National Drug Policy.

Methods:

We used a cross-sectional study design to analyze the DUP. We randomly selected 103 prescriptions dispensed to patients at the cardiac surgical outpatient during the study period. We critically examined these prescriptions for their consistency with WHO core drug use indicators.

Results:

The average number of drugs prescribed per person was 4.95. The most commonly prescribed top three drugs were antiplatelets (21.46%), beta-blockers (14.76%), and statins (13.78%). Most drugs were prescribed as single drugs (90.98%), whereas 9.02% were fixed-dose drug combinations (FDC). The combination of aspirin and clopidogrel was the most common prescribed FDC. The majority (72.44%) of the drugs prescribed were as per the NLEM 2015 list, whereas the generic name was low (2.8%). We measured Patient-Care Indicators and Facility-Specific Indicators also. The average consultation time and dispensing time were 7.76 and 3.23 min, respectively. The in-house pharmacy dispensed 82% of drugs. 93.75% of the key drugs were available in the facility. A copy of the essential drugs list was readily available in the facility. 96.67% of the patients knew the correct dosage of drugs.

Conclusions:

Anti-platelets and statins were the most commonly prescribed drugs. There was a high prescribing trend from the NLEM; however, the inclination to prescribe generic names was less. Patient-care and facility-specific indicators were also far from the optimal values except that of the average dispensing time.
Phase 1 Study of No-Carrier Added 177Lu-DOTATATE (SNU-KB-01) in Patients with Somatostatin Receptor–Positive Neuroendocrine Tumors: The First Clinical Trial of Peptide Receptor Radionuclide Therapy in Korea
Authors: Ryoo Hyun Gee , Suh Minseok , Kang Keon Wook , Lee Dae-Won , Han Sae-Won , Cheon Gi Jeong
Published: April 2022

Purpose To provide a wider choice of treatment opportunities for patients with neuroendocrine tumor (NET) in Korea, we have conducted a phase 1, open-label, single-arm, dose-escalation study of SNU-KB-01, a no-carrier added (NCA) 177Lu-labeled DOTATATE.Materials and Methods Seven patients with inoperable, progressive, metastatic, or locally advanced, somatostatin receptor-positive NET with Ki67 index ≤ 20% were enrolled according to the rolling six design. The study consisted of two cohorts to receive 4 cycles of SNU-KB-01 every 8 weeks for the first dose of 5.55 GBq (n=3) and 7.40 GBq (n=4). We assessed the incidence of dose-limiting toxicity (DLT) and adverse event, absorbed dose of kidneys and bone marrow, and objective tumor response.Results Seven patients completed 4 cycles (21.3-30.1 GBq total dose) of SNU-KB-01. The mean absorbed doses to kidneys and bone marrow were 0.500 mGy/MBq and 0.053 mGy/MBq, respectively, and the total body effective dose was 0.115 mSv/MBq. No DLT was observed and the maximum tolerated dose was 7.40 GBq/cycle. Grade 3 thrombocytopenia occurred in one patient, but no other grade 3 or 4 major hematologic or renal toxicity was observed. The best objective response to SNU-KB-01 was partial response. Overall response rate was 42.9% and disease control rate was 85.7%.Conclusion Treatment with 4 cycles of SNU-KB-01 was well tolerated and resulted in control of disease in most of the patients. Our results indicate SNU-KB-01, an NCA 177Lu-labeled DOTATATE, as a potentially safe and efficacious treatment option for NET patients in Korea.
Vpliv sistemske organiziranosti izobraževanja oseb s posebnimi potrebami na inkluzivno naravnanost učnih skupnosti
Authors: Jeznik Katja
Published: April 2022

Čim višja stopnja inkluzivnosti izobraževalnega sistema je cilj, h kateremu stremimo na vseh vzgojno-izobraževalnih ravneh. Inkluzivnost se nanaša na tiste posameznike in skupine, ki so bili skozi zgodovino večkrat izključeni, zaradi odstopanja od pričakovanih norm razvoja pa so bili pogosto tudi stigmatizirani. V članku so predstavljene glavne teoretske opredelitve koncepta inkluzije in sodobne sistemske rešitve vključevanja oseb s posebnimi potrebami v izobraževanje. Osredotočamo se na podobnosti in razlike med izobraževanjem oseb s posebnimi potrebami na različnih ravneh izobraževanja. Zanima nas, ali se identificirane prepreke na poti k inkluzivnosti šolskega sistema prenašajo z nižjih na višje ravni vzgojno-izobraževalnega sistema in kako to vpliva na inkluzivno naravnanost učnih skupnosti. Izhajamo iz analize relevantnih zakonodajnih dokumentov, spletnih strani, teoretske literature in sekundarnih virov o vključevanju oseb s posebnimi potrebami v sistem izobraževanja v Sloveniji. Ugotavljamo, da to, kar velja za izobraževalni sistem na douniverzitetni ravni, v veliki meri velja tudi za terciarno izobraževanje. Bolj kot inkluzivno se na vseh ravneh izobraževanja odraža integracijsko razumevanje vključevanja oseb s posebnimi potrebami. To hkrati pomeni odmik od širšega razumevanja inkluzije kot temelja za vzpostavljanje bolj inkluzivno naravnane učne skupnosti.
Unterrichtswahrnehmung von Literaturunterricht
Authors: Heins Jochen
Published: April 2022

Der Beitrag stellt Befunde einer Studie vor, in der die professionelle Unterrichtswahrnehmung von Bachelorstudierenden (N=4), Masterstudierenden (N=4) und Lehrer*innen (N=4) bei der Befassung mit Video-Vignetten aus dem Literaturunterricht untersucht wurde. Den Video-Vignetten sind typische Problemsituationen eingeschrieben (Heins 2018), die sich in ihrem Anforderungsniveau für die professionelle Wahrnehmung unterscheiden. In Form von reflektierenden Kommentaren liegen für alle Proband*innen Wahrnehmungsdaten zu beiden Vignetten vor. In einer strukturierenden und evaluativen inhaltsanalytischen Auswertung wurden die Daten hinsichtlich der Aufmerksamkeitsfokussierung, der Verarbeitungstiefe und des Erkennens der Problemsituationen kodiert. Die Befunde weisen darauf hin, dass ein Erkennen der fachdidaktischen Problemsituationen nur dann gelingt, wenn auch der fachliche Lerngegenstand und die Lernenden im Fokus der Aufmerksamkeit stehen. Dies gelingt den Proband*innen in Abhängigkeit vom Anforderungsniveau der Situation, was in dieser Studie als Hinweis auf den Entwicklungsstand der Disposition zur professionellen Unterrichtswahrnehmung angenommen wird.
Seismic Vulnerability Assessment for Various Shapes and Types of Reinforced Concrete Shear Walls in Multi-Storey Buildings
Authors: Nayak Chittaranjan Birabar , Jagadale Umesh Tukaram , Thakare Sunil Bhimro , Suryawanshi Nagesh Tatoba , Kate Gunavant Kashinath , Deulkar Wasudeo Narayanrao
Published: April 2022

To improve the lateral stiffness and economy, reinforced concrete shear walls are introduced in buildings. This study aims to conduct the seismic assessment of shear walls in a multi-storey building. In this work, various factors are investigated and their performance is compared for various shapes and types of shear walls with respect to strength, displacement, time period, etc. The building considered for the study purpose is a G+12 residential building and is situated in a high seismic zone. The response spectrum analysis of the building is carried out by using the software ETABS. The results show that shear walls not only reduce the seismic forces in a building, but also are advantageous if they are situated in proper positions.
Modified Digital Correlation Technique for Accurate Phase Measurement in Multi-Frequency Bio-Impedance Analysis
Authors: S Sruthi , Dhavse Rasika , Sarvaiya Jignesh
Published: April 2022

In bio-impedance analysis (BIA), high-frequency low-amplitude alternating current (AC) signals can incur time delays due to the capacitive nature of human cell membranes, and the characteristics of human tissues can be assessed from these delays in terms of phase changes. To accurately measure the phase changes, this work proposes a modified digital correlation-based phase measurement method. The accuracy of the general correlation technique is improved through digital direct synthesis (DDS) and digital correlation of unipolar square input signals. The proposed method is established through memory management and frequency adjustment. The result shows that, compared to the existing methods, the proposed method needs fewer hardware components, has better accuracy of 0.2° and higher frequency compatibility from 5 kHz to 1 MHz, and requires lower cost (140 USD). The method can be applied for the BIA of all types of tissues (recently used in COVID detection and care) and for the applications where efficient phase measurement is required.
Adopting Python-Kivy Framework for Personal Safety Application
Authors: Pinjani Pallavi , Dorvekar Nivedita , Mahajan Swati , Verma Raj
Published: April 2022

Now a days, with the help of internet technology, we can now stay connected with any one in any corner of the world. The internet network can be utilized to help out people in need of emergency. In this paper, we discuss about an android based safety application named ”personal safety application” proposed here aims at raising alerts and send notifications if anyone is facing any emergency in the form of any threat from someone, health emergency, accidental emergency, etc. The user can add his important contacts in the system whom he wants to inform in case of emergency. The user can send alerts through this application in the form of text, photo, video indicating an emergency along with other location details. GPS system will also help to find the exact location. This android-based safety application can help a group of people stay connected and help each other in case of any emergency in the least time possible.
Psychological Distress and Suicide Correlated with Long-Life Expectancy in Advanced Cancer Patients
Authors:   Medical Oncology Unit 1, IRCCS Ospedale Policlinico San Martino, Genova, Italy, Danila Comandini , Fabio Catalano ,   Medical Oncology Unit 1, IRCCS Ospedale Policlinico San Martino, Genova, Italy, Erika Romano ,   Clinical psychology and psychotherapy unit, IRCCS Ospedale Policlinico San Martino, Genova, Italy, Malvina Cremante ,   Medical Oncology Unit 1, IRCCS Ospedale Policlinico San Martino, Genova, Ital, Maria Laura Iaia ,   Medical Oncology Unit 1, IRCCS Ospedale Policlinico San Martino, Genova, Italy, Sara Elena Rebuzzi ,   Medical Oncology Unit, Ospedale San Paolo, Savona, Italy
Published: April 2022

OBJECTIVE Advances in systemic therapy together with better diagnostic and surgical techniques have contributing to survival improvement of many tumor types. Patients with cancer have an increased risk of suicide and the psychological impact of cancer is due the diagnosis itself, side effects of the therapy and cancer-related symptoms. METHOD The purpose of this study is to present the clinical case of an advanced gastrointestinal stromal tumor patient who committed suicide after 6 years of treatment. RESULT A 49-years-old male with a history positive only for an anxiety-depressive disorder was diagnosed with a locally advanced gastrointestinal stromal tumor. After 6 months of neoadjuvant imatinib, with stable disease, the patients decided to undergo surgery, with the subsequent resumption of adjuvant imatinib. Once the patient experienced disease progression, he preferred a surgical approach, even though he was aware that surgery was not the standard treatment and that a second-line systemic therapy was recommended. When the start of a second line therapy was the only possible treatment option, the patient has resigned himself to the idea that he would never be able to heal from cancer. After few months of second-line therapy he died of suicideSIGNIFICANCE OF RESULTS This case report shows that suicidality in cancer patients is a continuum spectrum from wanting to live, through the decreasing will to live, the readiness to die and then actively ending one’s life. Multidisciplinary teams should focus their attention not only on the disease itself but also on the cancer-related long-term psychological distress. Therefore, patient palliative care on psychological aspects should be improved strengthening psycho-social interventions during the entire cancer treatment history, not only at the end of life.
Study on an HMI system to induce appropriate and effective use of BSM at lane changing
Authors:   Shibaura Institute of Technology, JAPAN, Morooka Kenta , Kasuga Nobuyo
Published: April 2022

The installation of Advanced Driving Assistant Systems (ADAS) in vehicles is becoming obligatory in stage. However, it seems that many drivers do not fully understand the functions of ADAS and how to use them appropriately. Therefore, it is necessary to develop HMI systems to promote drivers’ appropriate use of ADAS. In this study, we focused on the Blind Spot Monitoring system (BSM) which indicates an approaching rear vehicle following in the neighboring lane with the indicator when the blinker is put out to change lanes. The system also gives alarm sound to deter lane changes that may cause an accident with the approaching rear vehicle. To improve the deterrence of the BSM against risky lane change, we designed an HMI system to supply information of the BSM by voice guidance and HUD. The effect of the system was verified by experiments and investigations. The HMI system was designed to inform whether the driver may be safe to change lanes, pay attention, or be in danger. We conducted experiments with twenty subjects using a Driving Simulator (DS). On the course of the DS, there were five places to change lanes. At one of them, no information was given to drivers when changing lanes. At two of them, information with an indicator was given by the BSM. At the other two, information via voice guidance and HUD by the HMI system were provided in addition to the BSM. The results of the experiments showed that there was no collision due to lane change made by the subjects ignoring risks when the HMI system activated, whereas there were two collisions (out of forty lane changes by twenty subjects) when the BSM activated only and was one (out of twenty lane changes by twenty subjects) without any information. It is also shown that the alarm of the BSM sounded six times (15%) when the HMI system activated, while it sounded twelve times (30%) when the BSM activated only. Due to the alarm, the subjects gave up changing lanes three times (50%) with the HMI system, while five times (44%) with the BSM only. These results indicate that the HMI system tends to increase deterrent force against risky lane changes. This means that the drivers tend to make safer decisions with a combination of the BSM and the HMI systems than with the BSM only. It is also shown that drivers tend to decrease the vehicle speeds after the HMI system activates. Analytical data show that many subjects highly appreciate the HMI system to continue safe driving. However, the data of pupil areas were significantly smaller with the HMI system. This implies that the concentration of drivers tends to decrease with the HMI system. The above results indicate that the HMI system is effective for drivers to be more aware of the risk of accidents when changing lanes and to make a safer decision. This remains to be an issue to determine whether drivers’ attention may tend to decrease with the HMI system.
A Study On Network Architecture For The Future Intelligent And Connected Vehicles(ICVS)
Authors:   Tongji University, CHINA, Fang Zihao , Luo Feng ,   Tongji University, CHINA, Wang Bowen ,   Tongji University, CHINA, Jin Yutao ,   Tongji University, CHINA, Li Qiujian ,   Tongji University, CHINA
Published: April 2022

Currently, intelligent and connected vehicles(ICVS) have been gradually proven to be the next generation of mobility. With the rapid development of automobile electronization, intelligentization and networking, the scale and complexity of the in-car electronic system are increasing day by day, and its intelligent systems such as lane departure warning and active collision avoidance system are also becoming more and more common. These systems require a lower delay, higher bandwidth and more reliability for vehicle network. Traditional vehicular network architecture can no longer meet the demand for automatic driving, entertainment, Multimedia, remote Diagnostic and Software Update, etc. Higher requirements are put forward for the relevant capability of automotive network architecture. For example, HD cameras, lidar and millimeter-wave radars are widely used in autonomous driving systems, and the data transmission of HD cameras and lidar requires a higher communication speed and more reliable network architecture to serve vehicle users. In the research of ICVS, network security has been paid more and more attention. In the field of ICVS, any network security is related to life safety. Therefore, the consideration of network security in network architecture is so critical. At the same time, to make ICVS more reliable, redundant design in the network architecture is also very important. The traditional CAN network cannot support the development of network security, while CANFD can support the functions of encryption and message authentication, and CANFD's bandwidth is much higher than that of CAN network. Automotive Ethernet can also carry out corresponding network security design, and its bandwidth has reached 100Mbps which is continuously developing. At the same time, in-vehicle Ethernet proposes AVB and TSN protocols, which can provide extremely low delay for keyframes. The synchronization protocol IEEE802.1AS and multiple scheduling protocols of the in-vehicle Ethernet work together to ensure the real-time performance of the system. The full-duplex transmission function of automotive Ethernet can also support the redundancy of the network architecture better. This paper analyzes the traditional vehicular network architecture and the current mainstream network architecture research and related technologies. This paper discusses the development trend of vehicular network architecture in the future. In consideration of real-time, bandwidth, reliability and safety requirements, a redundant hybrid network architecture with Ethernet backbone for future intelligent networked vehicles(ICVS) is proposed in this paper.