bluuebunny/crossref_metadata_2025 huggingface dataset:
Candidate Molecular Biomarkers of Traumatic Brain Injury: A Systematic Review
Authors: Butkova Tatiana V. , Malsagova Kristina A. , Nakhod Valeriya I. , Petrovskiy Denis V. , Izotov Alexander A. , Balakin Evgenii I. , Yurku Ksenia A. , Umnikov Alexey S. , Pustovoyt Vasiliy I. , Kaysheva Anna L.
Published: October 2024

Traumatic brain injury (TBI) is one of the leading causes of mortality and disability among young and middle-aged individuals. Adequate and timely diagnosis of primary brain injuries, as well as the prompt prevention and treatment of secondary injury mechanisms, significantly determine the potential for reducing mortality and severe disabling consequences. Therefore, it is crucial to have objective markers that indicate the severity of the injury. A number of molecular factors—proteins and metabolites—detected in the blood immediately after trauma and associated with the development and severity of TBI can serve in this role. TBI is a heterogeneous condition with respect to its etiology, clinical form, and genesis, being accompanied by brain cell damage and disruption of blood–brain barrier permeability. Two oppositely directed flows of substances and signals are observed: one is the flow of metabolites, proteins, and nucleic acids from damaged brain cells into the bloodstream through the damaged blood–brain barrier; the other is the infiltration of immune cells (neutrophils and macrophages) and serological proteins. Both flows aggravate brain tissue damage after TBI. Therefore, it is extremely important to study the key signaling events that regulate these flows and repair the damaged tissues, as well as to enhance the effectiveness of treatments for patients after TBI.
E-Skin and Its Advanced Applications in Ubiquitous Health Monitoring
Authors: Sun Xidi , Guo Xin , Gao Jiansong , Wu Jing , Huang Fengchang , Zhang Jia-Han , Huang Fuhua , Lu Xiao , Shi Yi , Pan Lijia
Published: October 2024

E-skin is a bionic device with flexible and intelligent sensing ability that can mimic the touch, temperature, pressure, and other sensing functions of human skin. Because of its flexibility, breathability, biocompatibility, and other characteristics, it is widely used in health management, personalized medicine, disease prevention, and other pan-health fields. With the proposal of new sensing principles, the development of advanced functional materials, the development of microfabrication technology, and the integration of artificial intelligence and algorithms, e-skin has developed rapidly. This paper focuses on the characteristics, fundamentals, new principles, key technologies, and their specific applications in health management, exercise monitoring, emotion and heart monitoring, etc. that advanced e-skin needs to have in the healthcare field. In addition, its significance in infant and child care, elderly care, and assistive devices for the disabled is analyzed. Finally, the current challenges and future directions of the field are discussed. It is expected that this review will generate great interest and inspiration for the development and improvement of novel e-skins and advanced health monitoring systems.
Machine Learning Reveals Microbial Taxa Associated with a Swim across the Pacific Ocean
Authors: Lewis Garry , Reczek Sebastian , Omozusi Osayenmwen , Hogue Taylor , Cook Marc D. , Hampton-Marcell Jarrad
Published: October 2024

Purpose: This study aimed to characterize the association between microbial dynamics and excessive exercise. Methods: Swabbed fecal samples, body composition (percent body fat), and swimming logs were collected (n = 94) from a single individual over 107 days as he swam across the Pacific Ocean. The V4 region of the 16S rRNA gene was sequenced, generating 6.2 million amplicon sequence variants. Multivariate analysis was used to analyze the microbial community structure, and machine learning (random forest) was used to model the microbial dynamics over time using R statistical programming. Results: Our findings show a significant reduction in percent fat mass (Pearson; p < 0.01, R = −0.89) and daily swim distance (Spearman; p < 0.01, R = −0.30). Furthermore, the microbial community structure became increasingly similar over time (PERMANOVA; p < 0.01, R = −0.27). Decision-based modeling (random forest) revealed the genera Alistipes, Anaerostipes, Bifidobacterium, Butyricimonas, Lachnospira, Lachnobacterium, and Ruminococcus as important microbial biomarkers of excessive exercise for explaining variations observed throughout the swim (OOB; R = 0.893). Conclusions: We show that microbial community structure and composition accurately classify outcomes of excessive exercise in relation to body composition, blood pressure, and daily swim distance. More importantly, microbial dynamics reveal the microbial taxa significantly associated with increased exercise volume, highlighting specific microbes responsive to excessive swimming.
Viro-Immunological Efficacy and Safety of Bictegravir/Emtricitabine/Tenofovir Alafenamide among Women Living with HIV: A 96-Week Post-Switch Analysis from the Real-Life SHiNe-SHiC Cohort
Authors: Colpani Agnese , De Vito Andrea , Marino Andrea , Ceccarelli Manuela , Celesia Benedetto Maurizio , Conti Giuseppe Nicolò , Spampinato Serena , Moi Giulia , Venanzi Rullo Emmanuele , Pellicanò Giovanni Francesco , Sofia Sonia Agata , Pantò Grazia , Iacobello Carmelo , Frasca Chiara Maria , Montineri Arturo , Albanese Antonio , Angioni Goffredo , Cacopardo Bruno , Madeddu Giordano , Nunnari Giuseppe ,   on behalf of Sardinian HIV Network and Sicilian HIV Cohort (SHiNe-SHiC) Research Group
Published: October 2024

Background/Objectives: Out of 39.9 million adults living with HIV in 2022, 20 million were women. Despite bearing a significant burden, women remain underrepresented in clinical trials, including those for antiretroviral treatments (ART). This study evaluates the safety and efficacy of the bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF) regimen in a real-life cohort of 99 women with HIV (females with HIV, FWH) over 48 and 96 weeks. Methods: A retrospective cohort study utilized data from the Sardinian HIV Network and Sicilian HIV Cohort (SHiNe-SHiC) research group. The study included FWH, who started B/F/TAF as a treatment switch. The primary objectives were achieving and maintaining an HIV RNA level of <50 copies/mL at 48 and 96 weeks. Secondary objectives included treatment safety, durability, and reasons for discontinuation. Data on demographics, viro-immunological markers, lipid profiles, and treatment interruptions were extracted for analysis. Results: Among the 99 FWH, the median age was 51.9 years, and the median duration of HIV was 15.1 years. At baseline, 80.8% had undetectable HIV-RNA, which increased to 93.8% at 96 weeks. There was a statistically significant increase in CD4 cells/mL (48w p < 0.001, 96w p < 0.001) and CD4/CD8 ratio (48w p < 0.009, 96w p < 0.048), and reductions in total cholesterol (48w p < 0.003, 96w p < 0.006) and LDL (48w p < 0.004, 96w p < 0.009) levels at 48 and 96 weeks. Nine treatment interruptions were noted, with one due to adverse events. The regimen was well-tolerated overall. Conclusions: B/F/TAF demonstrated high efficacy and safety in this real-world cohort of FWH, highlighting the critical need for gender-focused research in HIV treatment. Ensuring equitable access to effective treatment options for women is imperative for the global health community’s efforts to eliminate HIV.
Presepsin Does Not Predict Risk of Death in Sepsis Patients Admitted to the Intensive Care Unit: A Prospective Single-Center Study
Authors: Pluta Michał P. , Czempik Piotr F. , Kwiatkowska Magdalena , Marczyk-Bełbot Katarzyna , Maślanka Sebastian , Mika Jolanta , Krzych Łukasz J.
Published: October 2024

Background: Sepsis is defined as life-threatening organ dysfunction caused by an abnormal host response to infection. The study aimed to evaluate the utility of presepsin (P-SEP) in predicting the risk of death in patients with sepsis at the time of intensive care unit (ICU) admission. Methods: Adult patients were included in the study if they met SEPSIS-3 criteria at ICU admission. Demographic and clinical data were collected. The following inflammatory parameters were determined: C-reactive protein (CRP), procalcitonin (PCT), interleukin-6 (IL-6), and presepsin (P-SEP). Material was collected for microbiological testing depending on the suspected source of infection. The primary endpoint was patient death before ICU discharge. The secondary endpoint was a positive microbiological test result. Results: Eighty-six patients were included in the study. Thirty patients (35%) died before discharge from the ICU. There was no difference in P-SEP, CRP, PCT, and IL-6 values between patients who survived and those who died (p > 0.05 for all). P-SEP, CRP, PCT, and IL-6 were determined at ICU admission and did not accurately predict the risk of death in ROC curve analysis (p > 0.05 for all). Confirmation of the location of the focus of bacterial infection by microbiological testing was obtained in 43 (49%) patients. P-SEP, PCT, CRP, and IL-6 were significantly higher in patients with positive microbiological findings. Conclusions: In patients with suspected sepsis admitted to the Intensive Care Unit, presepsin does not accurately predict the risk of in-hospital death, but it can predict a positive microbiological culture.
From Gut to Blood: Redistribution of Zonulin in People Living with HIV
Authors: Augustin Max , Horn Carola , Ercanoglu Meryem Seda , Bondet Vincent , de Silva Ute Sandaradura , Suarez Isabelle , Chon Seung-Hun , Nierhoff Dirk , Zoufaly Alexander , Wenisch Christoph , Knops Elena , Heger Eva , Klein Florian , Duffy Darragh , Müller-Trutwin Michaela , Lehmann Clara
Published: October 2024

Background: Gastrointestinal mucosal damage due to human immunodeficiency virus (HIV) infection leads to microbial translocation and immune activation, contributing to the development of non-infectious comorbidities (NICM) in people living with HIV (PLWH). Additionally, persistent proviral HIV-1 in the gut-associated lymphatic tissue (GALT) can trigger immunological changes in the epithelial environment, impacting the mucosal barrier. However, the role of zonulin, a modulator of epithelial tight junctions in GALT during HIV infection, remains poorly understood. Methods: We measured zonulin in serum and intestinal tissue sections from five treatment-naive (HIV+NAIVE) and 10 cART-treated (HIV+cART) HIV+ individuals, along with 11 controls (CTRL). We compared zonulin levels with clinical characteristics, inflammatory markers (IFN-α, CXCR3, and PD-1), and the viral reservoir in peripheral blood (PB) and terminal ileum (TI). Results: Upon HIV infection, TI was found to harbor more HIV DNA than PB. Circulating zonulin levels were highest in HIV+NAIVE compared to HIV+cART or CTRL. Surprisingly, in the gut tissue sections, zonulin levels were higher in CTRL than in HIV+ individuals. Elevated circulating zonulin levels were found to be correlated with CD4+T-cell depletion in PB and TI, and with intestinal IFN-α. Conclusions: The findings of this study indicate a shift in zonulin levels from the gut to the bloodstream in response to HIV infection. Furthermore, elevated systemic zonulin levels are associated with the depletion of intestinal CD4+ T cells and increased gut inflammation, suggesting a potential link between systemic zonulin and intestinal damage. Gaining insight into the regulation of gut tight junctions during HIV infection could offer valuable understanding for preventing NICM in PLWH.
Development of the Parent–Child Communication Quality Scale from the Perspective of Children’s Psychological Needs
Authors: Lyu Wenhui , Shi Xiaohui , Xiong Zhiheng , Mu Yujie
Published: October 2024

Parent–child communication plays a crucial role in children’s healthy growth. Nevertheless, there is currently a paucity of instruments designed to measure the quality of parent–child communication from a psychological perspective. Accordingly, based on the self psychology theory, this study has developed the Parent–Child Communication Quality Scale (PCCQS) to assess the quality of parent–child communication in terms of the extent to which children’s psychological needs are met. A total of 1095 urban children (50.9% girls, M = 9.92, SD = 1.15) aged 8 to 12 years in eastern China were surveyed in this study. The measurement structure of the PCCQS was examined using an exploratory factor analysis (EFA) and a confirmatory factor analysis (CFA). The results of the CFA supported the second-order, four-factor structure of the PCCQS, with the 15-item PCCQS consisting of four factors (i.e., mirroring, idealization, empathy, and appropriate response). In conclusion, the PCCQS has good construct and criterion validity, as well as high internal consistency and split-half reliability. The scale is therefore a valuable tool for assessing the quality of parent–child communication.
Sustainability Assessments of Living Walls in the Mediterranean Area
Authors: Barreca Francesco , Cardinali Giuseppe Davide , Bruno Roberto , Arcuri Natale
Published: October 2024

The evaluation of the environmental impacts of a living wall (LW) system cannot leave out the effects on the buildings’ sustainability during its life cycle. Consequently, to consider the embodied impacts of all the components, an LCA of the whole system is recommended. Therefore, this paper was targeted to evaluate the environmental performances of four LW solutions considering a combination of energy performances and system LCA. In the first step, the yearly energy consumption of a reference building equipped with LWs was determined through simulations carried out in the EnergyPlus environment. Subsequently, the LCA completed the evaluation of the environmental impact of the different building configurations. To quantify the effects related to the implementation of LWs, the results were compared to those obtained for the reference building without vegetation. The analyses refer to a real university’s four-floor housing located in the city of Reggio Calabria (38°07′21.4″ N 15°39′45.2″ E), which is currently under construction. The results confirm the benefits achievable through the LW integration, measuring both energy savings and the increase in the hours with indoor temperature within the well-being zone. At an annual level, the best LW solution produces 24% of energy saving and LCA highlights a limitation of 2.1 × 105 kg of CO2eq when compared to the reference case. These data confirm the effectiveness of implementing LWs as a reliable intervention to enhance building environmental impact, especially for edifices requiring renovation.
Research on Damage Evolution Mechanism of Layered Rock Mass under Blasting Load
Authors: Xie Lixiang , Zhang Jiahao , Yang Dongyu , Qi Yanjun , Wu Linjun , Chen Hongyun
Published: October 2024

Rock mass consists of many discontinuities, such as faults, joints, etc., and layered joints are a common kind of rock mass structure. The joints affect the stress wave propagation, and blasting is an economical and efficient rock fragmentation method for rock mass engineering. So, the rock mass fragmentation effect and construction progress are affected by these layered joints. Numerical studies were carried out to analyze the damage evolution process of intact rock and rock mass with layered joints subjected to blasting loads based on the Riedel–Hiermaier–Thoma (RHT) model in LS-DYNA software (smp s R11.0.), and the effects of the location of initiation points and the fracture distribution on dynamic damage evolution of the rock mass were discussed. Bottom initiation tends to direct the blasting energy toward the blasthole mouth, resulting in effective rock fragmentation and ejection. Gradually adjusting the initiation point upward can improve the stress and damage distribution, allowing some of the blasting stress waves to propagate toward the bottom and enhance the fragmentation of the rock at the bottom. The distribution of layered joints exacerbates the damage to the rock mass on the upstream surface, but also acts as a certain shield to the propagation of stress waves, increasing the asymmetry of the damage distribution. It is useful to know the damage mechanism of the rock mass with layered joints to improve the effect of rock mass fragmentation by blasting. These results have very important theoretical significance and application value for the optimization of blasting construction technology.
Enhancing Intrapleural Hyperthermic Chemotherapy for Lung Cancer: Insights from 3D and PDX Models
Authors: Shin Jung Young , Lee Mi Ran , Choi Kyung Ah , Moon Seok Whan , Moon Mi Hyoung
Published: October 2024

Background/Objectives: Malignant pleural effusion (MPE) in lung cancer indicates systemically disseminated advanced lung cancer and is associated with poor survival. Intrapleural hyperthermic chemotherapy (IPHC) is a promising treatment for MPE; however, its biological basis is not fully understood. IPHC can enhance anticancer drug efficacy, particularly in drug-resistant cancers. This study investigated the effects of hyperthermia on cisplatin cytotoxicity in lung cancer cell lines, patient-derived tumor cells, and a patient-derived xenograft (PDX) model. Methods: Lung cancer cell lines (A549 and H2170) and patient-derived tumor cells were cultured in 2D/3D systems and treated with cisplatin under varying temperatures (37 °C, 43 °C, and 45 °C) and exposure times (5, 15, and 30 min). Antiproliferative effects were evaluated using LDH and CCK-8 assays. Optimal conditions identified in cell culture experiments were validated using a PDX model; tumor growth inhibition, delay, and protein expression were analyzed post-treatment. Results: Hyperthermia significantly enhanced the antitumor efficacy of cisplatin at 43 °C and 45 °C, with comparable effects under 15 and 30 min exposure. In the PDX model, IPHC showed increased tumor inhibition and necrosis and delayed tumor regrowth, particularly at higher cisplatin doses. Protein expression analysis revealed that hyperthermia decreased EGFR expression and increased levels of apoptosis-related proteins, including cleaved PARP and caspase-3. Conclusions: IPHC with cisplatin demonstrated enhanced antitumor efficacy in vitro models, particularly in drug-resistant lung cancer, indicating its potential as a valuable adjunct to existing treatment regimens for lung cancer and for improving patient outcomes in advanced lung cancer with MPE or pleural metastasis.
The Impact of Meteorological Factors on Stroke Incidence in the Transdanubian Region of Hungary
Authors: Horváth László , Verzár Zsófia , Csákvári Tímea , Szapáry László , Domján Péter , Bálint Csaba , Khatatbeh Haitham , Ali Amira Mohammed , Pakai Annamária
Published: October 2024

Cerebrovascular diseases are the leading cause of death and disability. The epidemiological background and predisposing factors have been the basis of many studies. We aimed to assess the effect of seasonal variability and meteorological factors on stroke incidence in Hungary. National and county-level secondary data were assessed for 2018–2019. We identified stroke with ICD codes I60, I61, I62 (hemorrhagic), I63, I65, and I66 (ischemic). The data were obtained from the University of Pécs Clinical Centre (number of patients per day according to sex and disease subtype, n = 1765). Daily average and maximum wind speed [m/s], precipitation [mm], temperature [°C], and frontal effect [warm/cold/mixed/no effect]) were provided by the Hungarian Meteorological Service. We found that 89.92% of the patients were hospitalized for ischemic and 10.08% for hemorrhagic stroke. We observed a significantly higher number of cases in the other months compared to winter (spring: +35.9%; p = 0.007, summer: +59.0%; p = 0.016, autumn: +36.5%; p = 0.01). In autumn, an increase in temperature increased the incidence of stroke (r = 0.210; p = 0.004). Temperature change affected ischemic stroke incidence (r = 0.112; p = 0.003). In contrast, the number of hemorrhagic stroke cases showed a mild but significant negative association with daily temperature change (r = −0.073; p = 0.049). Overall, a 1 °C temperature change compared to the previous day increased the daily number of admissions by 2.9% (p = 0.017). Air pressure change also affected hemorrhagic stroke incidence (r = 0.083; p = 0.025). Changes in temperature and frontal effects can increase the incidence of stroke. Modern forecasting technology can help the healthcare system prepare for possible increased workloads during critical periods.
Development of Pericarp-Based Coatings from Corn Nixtamalization Residue for Stone Fruits: Applications for Peach and Tejocote
Authors: Rojas-Candelas Liliana Edith , Duque-Buitrago Luisa Fernanda , Díaz-Ramírez Mayra , González-Vázquez Marcela , Arredondo-Tamayo Benjamín , Méndez-Méndez Juan V. , Rentería-Ortega Minerva , Quiroz-Estrada Karla
Published: October 2024

This study investigated corn pericarp, a by-product of the nixtamalization process, in developing sustainable films for fruit coatings. These films were evaluated for their optical, structural, barrier, and mechanical properties. The results showed that the pericarp films were transparent, had heterogeneous surfaces, and exhibited favorable mechanical and barrier properties, suggesting their potential as fruit coatings. The pericarp films significantly extended shelf life when applied to peaches and tejocotes postharvest. The films slowed the maturation process, as evidenced by minimal changes in peel and mesocarp color for up to five days for tejocotes and even longer for peaches. Additionally, coated fruits showed slower rates of weight loss, firmness reduction, and decreases in titratable acidity, total soluble solids, and total sugar content compared to control samples. These findings demonstrate the potential of corn pericarp films as effective coatings for extending the shelf life of stone fruits.
Examining the Influence of Corruption on the Practice of Trophy Hunting in South Africa
Authors: Peyman Adam J. , Styles Megan A.
Published: October 2024

This study examines the perceived influence of corruption on the practice of trophy hunting in South Africa, the largest trophy exporter in Africa. Corruption is a major problem in South Africa, where it takes the form of bribery and embezzlement. To investigate its perceived effects on the practice of trophy hunting, semi-structured interviews were conducted with 15 trophy hunting stakeholders in South Africa. Interviews were conducted via Zoom, recorded, transcribed, and coded using a qualitative content analysis. Six of the 15 respondents had personally witnessed corruption in the trophy hunting industry in South Africa, and 13 respondents had heard accounts of corruption witnessed or experienced by others. Respondents identified several perceived problems caused by corruption in the trophy hunting industry and suggested ways to mitigate corruption. Based on these results, a multi-pronged approach for addressing corruption within the trophy hunting industry in South Africa may be necessary.
Application of the Summary of Diabetes Self-Care Activities Questionnaire in Evaluating the Self-Care of People with Diabetes
Authors: Gaćina Snježana , Mlačak Blaž , Bulum Tomislav , Filej Bojana
Published: October 2024

Objectives: This uncontrolled open study aimed to measure the levels of self-care of patients before and after education, their initial knowledge, and their knowledge two months after interacting with healthcare providers using the Summary of Diabetes Self-Care Activities (SDSCA) questionnaire. Methods: The data for this study were collected over 14 months from 396 patients with diabetes. This study was conducted in three phases: initial questionnaire testing, education, and retesting after two months. The education included specific diabetes-related topics: nutrition, exercise, self-monitoring of blood glucose, foot care, and smoking. Results: The results showed that all self-care activities between the first and second assessments were different. The initial assessment showed that the more successful the general diet, the specific diet, and physical activity were, the better the hemoglobin A1c value was. When considering the impact of gender on self-care effectiveness results, it was noted that women were more successful in foot care and specific diet in the initial testing, while men excelled in physical activity. The most successful age group in the scales of general diet, physical activity, and blood glucose testing was 31–45 years. Those with type 1 diabetes (36% of the study population) were more successful in self-care in the first and second measurements but without any differences in self-care in the retesting. Conclusions: our study observed a difference in self-care results between the two measurements of self-care activities in patients with diabetes, evaluated by the SDSCA questionnaire.
A Novel Compound Nonsense Variant in CYP27B1 Causes an Atypical Form of Vitamin D-Dependent Rickets Type 1A: A Case Report of Two Siblings in a Mexican Family
Authors: Toral López Jaime , Candia Tenopala Cesar , Reyes Mosqueda Alix Daniela , Fonseca Sánchez Miguel Ángel , González Huerta Luz María
Published: October 2024

Background: Vitamin D-dependent rickets type 1A (VDDR1A) is a rare autosomal recessive disorder caused by pathogenic variants in the CYP27B1 gene, typically characterized by growth failure, rickets, leg bowing, fracture, seizures, hyperparathyroidism, hypocalcemia, high-alkaline phosphatase, high or normal 25(OH)D3, and low 1,25(OH)2D3. Methods: We studied two siblings in a Mexican family with an atypical form of VDDR1A. In addition to the typical features of VDDR1A, the proband showed cafe au lait spots, small teeth, and grayish sclera, with hypophosphatemia, normocalcemia, and normal 25(OH)D3; the proband’s brother showed grayish sclera. The proband underwent next generation sequencing. Sanger sequencing was performed in the proband, his brother, the parents, and 100 healthy controls validate the detected variant. Results: Both brothers presented with a recurrent variant NM_000785.3; c.1319_1325dupCCCACCC and a novel nonsense variant NM_000785.3; c.227G>A in the CYP27B1 gene. Conclusions: Calcitriol treatment had a better response in proband´s younger brother. We describe the first Mexican family with an atypical form of VDDR1A associated with a novel nonsense variant, the results contribute to the phenotypic spectrum and increase the pool of pathogenic variants in CYP27B1. Data suggest that nonsense-truncating variants play a significant role in the severity of VDDR1A.
Hybrid Beamforming Structure Using Grouping with Reduced Number of Phase Shifters in Multi-User MISO
Authors: Hayakawa Hiroya , Handa Yudai , Tanaka Riku , Tamura Kosuke , Cha Jaesang , Ahn Chang-Jun
Published: October 2024

This paper proposes a novel hybrid beamforming (HBF) structure for gain-aware grouping transmit antennas and users in multiuser multiple-input single-output (MU-MISO) systems. In the conventional HBF structure, all transmit antennas form a beam to each user. In this case, the gain of each antenna varies depending on the location of the base station and each user, and the transmit power after the digital beamformer is allocated to the antenna with the smallest gain. Signals transmitted from antennas with small gains are susceptible to noise and interference. Therefore, this paper proposes an HBF structure in which only the antenna with the highest gain forms the beam for each user. In the proposed scheme, the transmitting antennas are grouped and the beam is formed only by the group of antennas with the highest gain for each user. Simulation results show that the proposed scheme can reduce the number of phase shifters used on the transmit side compared to the conventional HBF scheme while maintaining sum-rate performance when the number of transmit antennas and users are the same. It was also shown that there is a trade-off between the reduction in the number of phase shifters used to form the beam and the improvement in performance as the number of transmit antennas increases. Furthermore, it is shown that when antenna selection is used, although there is a trade-off between the number of phase shifters and performance improvement, the number of phase shifters can be reduced while maintaining performance even when the number of transmit antennas increases.
Enhancing Federated Learning in Heterogeneous Internet of Vehicles: A Collaborative Training Approach
Authors: Wu Chao , Fan Hailong , Wang Kan , Zhang Puning
Published: October 2024

The current Internet of Vehicles (IoV) faces significant challenges related to resource heterogeneity, which adversely impacts the convergence speed and accuracy of federated learning models. Existing studies have not adequately addressed the problem of resource-constrained vehicles that slow down the federated learning process particularly under conditions of high mobility. To tackle this issue, we propose a model partition collaborative training mechanism that decomposes training tasks for resource-constrained vehicles while retaining the original data locally. By offloading complex computational tasks to nearby service vehicles, this approach effectively accelerates the slow training speed of resource-limited vehicles. Additionally, we introduce an optimal matching method for collaborative service vehicles. By analyzing common paths and time delays, we match service vehicles with similar routes and superior performance within mobile service vehicle clusters to provide effective collaborative training services. This method maximizes training efficiency and mitigates the negative effects of vehicle mobility on collaborative training. Simulation experiments demonstrate that compared to benchmark methods, our approach reduces the impact of mobility on collaboration, achieving large improvements in the training speed and the convergence time of federated learning.
Generation Z Satisfaction with Smart Homestays: ASCI and Web Crawler Insights from China
Authors: Wang Xiaoyu , Xu Junping , Pan Younghwan
Published: October 2024

In the digital context, smart homestays have developed rapidly in the post-epidemic era and have become a new form of accommodation. Homestays are favored by many young people in China, such as those belonging to Generation Z. According to data concerning China’s national tourism and related reports, the demand for homestays has increased dramatically in recent years. Thus, we need to consider how to improve the smart homestay user experience. Based on the American Customer Satisfaction Index (ACSI) model, this study explores the factors that affect the user experience of smart homestays. An online survey of 370 respondents of Generation Z in China was conducted, followed by descriptive statistical analysis and hypothesis model validation using SPSS 26.0. The data show that among the five service variables (reservation, check-in, living, check-out, and information sharing), perceived value has a positive and positive impact on service variables in all aspects. Finally, machine learning is used for emotion text analysis, and the results show that users are biased towards smart homestays in the sentiment analysis of the comments. Although smart homestays have a certain amount of attention, there is still a lot of room for progress in technology and services. The purpose of this study is to improve and perfect the rules for making smart homestay service standards based on understanding the satisfaction of Generation Z when using smart homestays while also providing a theoretical basis and practical manuals for the industry to promote the development of the industry and improve user experience. Based on the research results of the above literature, it is imperative to carry out research on Generation Z, the main force of future consumption, especially in the field of artificial intelligence.
Zero Trust Cybersecurity: Procedures and Considerations in Context
Authors: Lund Brady D. , Lee Tae-Hee , Wang Ziang , Wang Ting , Mannuru Nishith Reddy
Published: October 2024

In response to the increasing complexity and sophistication of cyber threats, particularly those enhanced by advancements in artificial intelligence, traditional security methods are proving insufficient. This paper provides an overview of the zero-trust cybersecurity framework, which operates on the principle of “never trust, always verify” to mitigate vulnerabilities within organizations. Specifically, this paper examines the applicability of zero-trust principles in environments where large volumes of information are exchanged, such as schools and libraries, highlighting the importance of continuous authentication (proving who users are within the network), least privilege access (providing only access to what users specifically need), and breach assumption (assuming a breach has or will occur and thus operating to limit the spread through the use of multiple checkpoints throughout the network). The analysis highlights avenues for future research that may help preserve the security of vulnerable organizations.
Comparative Genomics of Eight Complete Chloroplast Genomes of Phyllostachys Species
Authors: Li Guolei , Liu Guohua , Liu Changlai
Published: October 2024

(1) Background: The genus Phyllostachys belongs to the subfamily Bambusoideae within the family Gramineae. Bamboos of this genus are distinguished by their remarkable genetic traits, including exceptional resistance to both cold and drought conditions. These species possess considerable economic, ecological, and aesthetic value, finding extensive use in forestry and landscape design across China. (2) Methods: This study employed Illumina’s second-generation sequencing technology to sequence the chloroplast genomes of eight Phyllostachys species, followed by their assembly and annotation. (3) Results: The chloroplast genomes of the genus exhibit a characteristic tetrad structure with an average sequence length of 139,699 bp and an average GC content of 38.9%. A total of 130 genes have been annotated across eight bamboo species, comprising 75 protein-coding genes, 28 tRNA genes, and four rRNA genes. Global alignment and nucleotide polymorphism analyses indicate that the chloroplast genome of Phyllostachys is highly conserved overall. The boundaries of the four chloroplast regions are relatively conserved and exhibit minimal differences. Among these regions, three coding region genes—atpH, trnQ-UUG, and petB—and five non-coding regions—rpl32-trnL-UAG, rpl14-rpl16, rpl22-rps19, rps12-clpP, and trnR-UCU-trnM-CAU—exhibit high polymorphism and can be used as potential hotspot areas for subsequent research. A total of 266 simple sequence repeat (SSR) loci were identified by SSR analysis in the chloroplast genomes of eight bamboo species; the largest number of mononucleotide repeats was 154, predominantly consisting of A/T. Codon bias in the chloroplast genomes of the eight bamboo species indicates a preference for codons ending with A and U. Additionally, the UUA codon, which encodes leucine (Leu), is positioned between codons encoding phenylalanine (Phe), lysine (Lys), leucine (Leu), serine (Ser), and tyrosine (Tyr), indicating certain differences among these species. (4) Conclusions: This study aims to offer novel insights into the population genetics, phylogenetic relationships, and evolutionary patterns of Phyllostachys.
Study on Mechanical Properties of Steel-Strengthened Bamboo Beams with Webbing Opening
Authors: Liu Binhao , Liao Wenyuan , Zhang Tianyu , Yu Yue , Dai Bihui , Liu Dewen , Chen Shaozhi , Li Bingjin
Published: October 2024

Bamboo beams are often reinforced with built-in steel sections to enhance their strength and load-bearing capacity. In this paper, we studied the effect of different parameters, including the location of the hole, the hole size, and the thicknesses of the steel and bamboo, on the mechanical properties of reinforced beams. The damage patterns, deformation characteristics, and force-transfer mechanisms, as well as the mechanical properties of reinforced beams with different hole shapes, underwent non-linear finite element analysis. The damage sustained by the reinforced bamboo beam differed from that of the traditional bamboo beam; two diagonal points formed a plastic hinge, mainly during the process of shear damage to the hole. It was determined that the hole size and the thickness of the bamboo have the greatest influence on the mechanical properties of the reinforced beam. The damage characteristics of the composited beams with different holes are similar; the bearing capacity of reinforced beams with open square holes is reduced by 10%–25%compared with circular holes.
Countering Social Media Cybercrime Using Deep Learning: Instagram Fake Accounts Detection
Authors: Alharbi Najla , Alkalifah Bashayer , Alqarawi Ghaida , Rassam Murad A.
Published: October 2024

An online social media platform such as Instagram has become a popular communication channel that millions of people are using today. However, this media also becomes an avenue where fake accounts are used to inflate the number of followers on a targeted account. Fake accounts tend to alter the concepts of popularity and influence on the Instagram media platform and significantly impact the economy, politics, and society, which is considered cybercrime. This paper proposes a framework to classify fake and real accounts on Instagram based on a deep learning approach called the Long Short-Term Memory (LSTM) network. Experiments and comparisons with existing machine and deep learning frameworks demonstrate considerable improvement in the proposed framework. It achieved a detection accuracy of 97.42% and 94.21% on two publicly available Instagram datasets, with F-measure scores of 92.17% and 89.55%, respectively. Further experiments on the Twitter dataset reveal the effectiveness of the proposed framework by achieving an impressive accuracy rate of 99.42%.
Prediction and Visualization of Total Volatile Basic Nitrogen in Yellow Croaker (Larimichthys polyactis) Using Shortwave Infrared Hyperspectral Imaging
Authors: Kim Sang Seop , Yun Dae-Yong , Lee Gyuseok , Park Seul-Ki , Lim Jeong-Ho , Choi Jeong-Hee , Park Kee-Jai , Cho Jeong-Seok
Published: October 2024

In the present investigation, we have devised a hyperspectral imaging (HSI) apparatus to assess the chemical characteristics and freshness of the yellow croaker (Larimichthys polyactis) throughout its storage period. This system operates within the shortwave infrared spectrum, specifically ranging from 900 to 1700 nm. A variety of spectral pre-processing techniques, including standard normal variate (SNV), multiple scatter correction, and Savitzky–Golay (SG) derivatives, were employed to augment the predictive accuracy of total volatile basic nitrogen (TVB-N)—which serves as a critical freshness parameter. Among the assessed methodologies, SG-1 pre-processing demonstrated superior predictive accuracy (Rp2 = 0.8166). Furthermore, this investigation visualized freshness indicators as concentration images to elucidate the spatial distribution of TVB-N across the samples. These results indicate that HSI, in conjunction with chemometric analysis, constitutes an efficacious instrument for the surveillance of quality and safety in yellow croakers during its storage phase. Moreover, this methodology guarantees the freshness and safety of seafood products within the aquatic food sector.
Plant-Based Ingredients Utilized as Fat Replacers and Natural Antimicrobial Agents in Beef Burgers
Authors: Lombardi Silvia Jane , Pannella Gianfranco , Coppola Francesca , Vergalito Franca , Maiuro Lucia , Succi Mariantonietta , Sorrentino Elena , Tremonte Patrizio , Coppola Raffaele
Published: October 2024

The present study aimed to find solutions based on the use of plant-based ingredients that would improve the nutritional quality of meat products as well as ensure sensory and microbiological quality. Two fat replacers, lemon albedo (Citrus lemon) and carob seed gum (Ceratonia siliqua), were investigated by chemical analysis and panel testing to evaluate their effect on the nutritional and sensory quality of beef burgers. The antimicrobial activity of two plant extracts, from nettle (Urtica dioica) leaves and medlar (Eriobotrya japonica) seeds, was studied, evaluating the intensity of inhibitory action and the minimum inhibitory concentration against Pseudomonas spp. and Listeria innocua strains by plate test. In addition, the antioxidant activity of both extracts was evaluated. Based on the results, lemon albedo and medlar seed extracts were validated in a food model (beef burger) by a storage test and a challenge test. The storage test results highlight that medlar seed extract prevents the formation of thiobarbituric acid reactive substances (TBARSs) and ensures microbiological quality, inhibiting Enterobacteriaceae and Pseudomonas spp. Anti-Listeria efficacy was confirmed in situ by challenge test results. In conclusion, although fat replacers ensure nutritional and sensory quality, they do not satisfy microbiological quality. This study clearly demonstrates that the safety of low-fat burgers can only be achieved through the combination of appropriate fat replacers with well-selected natural antimicrobial extracts.
Effects of Mixing and Large-Amplitude Oscillatory Shear Deformations on Microstructural Properties of Gliadin and Glutenin as Captured by Stop-Flow Frequency Sweeps in Small-Amplitude Oscillatory Shear
Authors: Yazar Gamze , Smith Brennan , Kokini Jozef L.
Published: October 2024

Gliadin and glutenin extracted from vital wheat gluten were studied using Large Amplitude Oscillatory Shear (LAOS) followed by stop-flow frequency sweep tests after being subjected to short (4 min) and prolonged (60 min) mixing times. The LAOS tests were conducted at up to two different strain amplitudes (γ: 0.1%, 200%; ω: 10 rad/s) to apply small and large deformations to the gliadin and glutenin after mixing for different time periods. Frequency sweep tests (ω: 0.01–100 rad/s, γ: 0.06%) revealed an increase in the elasticity of gliadin with respect to an increasing mixing time, as evidenced by a robust increase in G′(ω), coupled with a less robust increase in G″(ω). Consistent with the increase in elasticity, a progressively lower tanδ(ω) and G′(ω) slope were observed for the gliadin that underwent 60 min of mixing followed by large LAOS deformations. However, G′(ω), G″(ω), and η*(ω) remained constant for glutenin as the mixing time increased. Elastic decay with an increase in tanδ(ω) was found for glutenin when subjected to prolonged mixing followed by large LAOS deformations, which became apparent at high frequencies. The stop-flow LAOS (non-linear region)–frequency sweep (linear region) tests provided an understanding of how exposure to different mixing times and LAOS deformations of different magnitudes influence the mechanical/rheological properties of the main gluten proteins.
Effect of Sinapine on Microstructure and Anti-Digestion Properties of Dual-Protein-Based Hydrogels
Authors: Li Youdong , Duan Mengxin , Liu Guoyan , Liang Li , Liu Xiaofang , Zhang Jixian , Wen Chaoting , Xu Xin
Published: October 2024

Sinapine is a natural polyphenol from the cruciferous plant family that has anti-aging effects but is low in bioavailability. To improve the bioavailability and therapeutic effect of sinapine, sinapine-crosslinked dual-protein-based hydrogels were prepared using soy protein isolate as a cross-linking agent. The preparation conditions were optimized by single-factor experiments, and the optimal ratios were obtained as follows: the concentration of sinapine was 300 μg/mL; the water–oil ratio was 1:3. The encapsulation rate was greater than 95%, and the drug loading capacity was 3.5 mg/g. In vitro, digestion experiments showed that the dual-protein-based hydrogels as a drug carrier stabilized the release of sinapine and improved the bioavailability of sinapine by 19.3%. The IC50 of DPPH antioxidants was 25 μg/mL as determined by in vitro digestion, and the antioxidant capacity of ABTS was about 20% higher than that of glutaraldehyde control. This is due to the addition of sinapine to enhance the antioxidant properties of the system. It can be seen that the developed hydrogels have potential applications in related fields, such as food nutrition fortification and drug delivery.
Multiple Solutions for a Critical Steklov Kirchhoff Equation
Authors: Alyami Maryam Ahmad , Ghanmi Abdeljabbar
Published: October 2024

In the present work, we study some existing results related to a new class of Steklov p(x)-Kirchhoff problems with critical exponents. More precisely, we propose and prove some properties of the associated energy functional. In the first existence result, we use the mountain pass theorem to prove that the energy functional admits a critical point, which is a weak solution for such a problem. In the second main result, we use a symmetric version of the mountain pass theorem to prove that the investigated problem has an infinite number of solutions. Finally, in the third existence result, we use a critical point theorem proposed by Kajikiya to prove the existence of a sequence of solutions that tend to zero.
Synthesis of Organic and Inorganic Compounds in Asymptotic Giant Branch Stars
Authors: Kwok Sun
Published: October 2024

After the synthesis of carbon in the core of asymptotic giant branch (AGB) stars, carbon is dredged up to the surface by convection. Many carbon-based molecules are formed in the subsequently developed stellar wind. These include acetylene, which can link together to form benzene in post-AGB evolution. The emergence of the spectral signatures of aromatic and aliphatic compounds in the transition phase between AGB stars and planetary nebulae suggests that complex organic compounds can be formed in the circumstellar environment over very short (103 yr) timescales. We suggest that the carrier of the family of unidentified infrared emission bands is an amorphous carbonaceous compound—mixed aromatic/aliphatic nanoparticles (MAONs). The implications of the synthesis of complex organics in evolved stars are discussed.
Sol–Gel Derived Alumina Particles for the Reinforcement of Copper Films on Brass Substrates
Authors: Mohamed Samah Sasi Maoloud , Vuksanović Marija M. , Vasiljević-Radović Dana G. , Janković Mandić Ljiljana , Jančić Heinneman Radmila M. , Marinković Aleksandar D. , Mladenović Ivana O.
Published: October 2024

The aim of this study is to provide tailored alumina particles suitable for reinforcing the metal matrix film. The sol–gel method was chosen to prepare particles of submicron size and to control crystal structure by calcination. In this study, copper-based metal matrix composite (MMC) films are developed on brass substrates with different electrodeposition times and alumina concentrations. Scanning electron microscopy (FE-SEM) with energy-dispersive spectroscopy (EDS), TEM, and X-ray diffraction (XRD) were used to characterize the reinforcing phase. The MMC Cu-Al2O3 films were synthesized electrochemically using the co-electrodeposition method. Microstructural and topographical analyses of pure (alumina-free) Cu films and the Cu films with incorporated Al2O3 particles were performed using FE-SEM/EDS and AFM, respectively. Hardness and adhesion resistance were investigated using the Vickers microindentation test and evaluated by applying the Chen–Gao (C-G) mathematical model. The sessile drop method was used for measuring contact angles for water. The microhardness and adhesion of the MMC Cu-Al2O3 films are improved when Al2O3 is added. The concentration of alumina particles in the electrolyte correlates with an increase in absolute film hardness in the way that 1.0 wt.% of alumina in electrolytes results in a 9.96% increase compared to the pure copper film, and the improvement is maximal in the film obtained from electrolytes containing 3.0 wt.% alumina giving the film 2.128 GPa, a 134% hardness value of that of the pure copper film. The surface roughness of the MMC film increased from 2.8 to 6.9 times compared to the Cu film without particles. The decrease in the water contact angle of Cu films with incorporated alumina particles relative to the pure Cu films was from 84.94° to 58.78°.