bluuebunny/crossref_metadata_2025 huggingface dataset:
Did pediatric drug development advance epilepsy treatment in young patients? It is time for new research goals
Authors: Ettienne Earl B , Russo Emilio , Striano Pasquale , Grant-Kels Jane M , Rose Klaus
Published: June 2024

Modern drugs have changed epilepsy, which affects people of all ages. However, for young people with epilepsy, the framework of drug development has stalled. In the wake of the thalidomide catastrophe, the misconception emerged that for people < 18 years of age drugs, including antiseizure medications (ASMs), need separate proof of efficacy and safety, overall called "pediatric drug development". For ASMs, this has changed to some degree. Authorities now accept that ASMs are effective in < 18 years as well, but they still require "extrapolation of efficacy," as if minors were another species. As a result, some of the pediatric clinical epilepsy research over the past decades was unnecessary. Even more importantly, this has hampered research on meaningful research goals. We do not need to confirm that ASMs work before as they do after the 18th birthday. Instead, we need to learn how to prevent brain damage in young patients by preventing seizures and optimize ASMs’ uses. Herein we discuss how to proceed in this endeavor.
Revisiting the standards of cancer detection and therapy alongside their comparison to modern methods
Authors: Gromek Piotr , Senkowska Zuzanna , Płuciennik Elżbieta , Pasieka Zbigniew , Zhao Lin-Yong , Gielecińska Adrianna , Kciuk Mateusz , Kłosiński Karol , Kałuzińska-Kołat Żaneta , Kołat Damian
Published: June 2024

In accordance with the World Health Organization data, cancer remains at the forefront of fatal diseases. An upward trend in cancer incidence and mortality has been observed globally, emphasizing that efforts in developing detection and treatment methods should continue. The diagnostic path typically begins with learning the medical history of a patient; this is followed by basic blood tests and imaging tests to indicate where cancer may be located to schedule a needle biopsy. Prompt initiation of diagnosis is crucial since delayed cancer detection entails higher costs of treatment and hospitalization. Thus, there is a need for novel cancer detection methods such as liquid biopsy, elastography, synthetic biosensors, fluorescence imaging, and reflectance confocal microscopy. Conventional therapeutic methods, although still common in clinical practice, pose many limitations and are unsatisfactory. Nowadays, there is a dynamic advancement of clinical research and the development of more precise and effective methods such as oncolytic virotherapy, exosome-based therapy, nanotechnology, dendritic cells, chimeric antigen receptors, immune checkpoint inhibitors, natural product-based therapy, tumor-treating fields, and photodynamic therapy. The present paper compares available data on conventional and modern methods of cancer detection and therapy to facilitate an understanding of this rapidly advancing field and its future directions. As evidenced, modern methods are not without drawbacks; there is still a need to develop new detection strategies and therapeutic approaches to improve sensitivity, specificity, safety, and efficacy. Nevertheless, an appropriate route has been taken, as confirmed by the approval of some modern methods by the Food and Drug Administration.
LEGAL ANALYSIS OF WITNESS TESTIMONIUM DE AUDITU’S POSITION ON DECISION NO. 115/PID.SUS/2021/PN.KTG
Authors: Mbewa Adelina , Haryadi Wahyu Tris
Published: June 2024

Testmonium de audito has not been accepted as evidence under the Criminal Procedure Code because its authenticity has not been tested. Under the Constitutional Court’s decision No.65/PUU-VIII/2010, testimonium de audito is considered as evidence, and can be used in both criminal and civil cases. Therefore, this research is conducted to determine the witness's position in the trial and verdict Number 115/Pid.Sus/2021/PN.Ktg. The case study of Kotamobagu District Court Decision Number 115/Pid.Sus/2021/PN.Ktg and Law No. 8/1981 on the Criminal Procedure Code become the basis of normative legal research methodology in this research, which also used primary and secondary sources. The findings of this research indicate that in Constitutional Court Decision No.65/PUU-VIII/2010, law enforcers should agree that witnesses who actually see, hear, or suffer a criminal event are not always required. On the other hand, Testimonium de Auditu witnesses cannot be used as independent witnesses in the case of Decision No. 115/Pid.Sus/2021/PN.Ktg because it does not include the requirements of the witnesses required.
IMPLEMENTATION OF GRANTING HEALTHCARE FACILITIES RIGHTS FOR PREGNANT FEMALE PRISONERS AT CLASS II A SURABAYA WOMEN’S PENITENTIARY
Authors: Lestari Yashinta Dwi , Prasetyo Dr. Dossy Iskandar
Published: June 2024

The fulfilment of prisoners’ rights must be granted to every prisoner, including children, men, and women, as stipulated in Law No. 12/1995. Fulfilment of these rights includes the right to receive healthcare and proper food. The treatment between female and male prisoners is quite different, especially for pregnant prisoners. Therefore, this research aims to find out the implementation of granting healthcare facilities to pregnant prisoners in women’s detention centre class IIA Surabaya. This type of research is empirical juridical with a combination of qualitative and quantitative approaches. There are 2 sources of legal material used, such as (1) the primary legal source comes from community legal aid institutions, the right to health pocket book, Law No. 22/2022 on correctional facilities, Law No. 39/1999 on human rights; (2) the secondary legal source comes from the results of filling out questionnaires and interviews. Although the health facilities provided in the detention centre are supportive, some pregnant prisoners stated that the health services provided were inadequate and there was a lack of counselling on pregnancy programmes. Therefore, the detention centre seeks to fulfil the health rights of pregnant prisoners as stated in Law No. 22/2022.
LEGAL REVIEW OF INFRINGEMENT PROSECUTION UNDER GOVERNMENT REGULATION OF INDONESIA NO. 80/2012 THROUGH TELEGRAM LETTER OF THE HEAD OF INDONESIAN NATIONAL POLICE NO. ST/2264/X/HUM.3.4.5./2022
Authors: Putra Erki Maulana , Sholehuddin Dr. M.
Published: June 2024

The issuance of the telegram letter of the Head of Indonesian National Police No. ST/2264/X/HUM.3.4.5/2022, on 18 October 2022, has an impact on traffic law enforcement. The letter prohibits police officers from manually ticketing traffic violators. After the issuance of the letter, there was a norm conflict with Government Regulation No. 80/2012. This research aims to determine the legal authority between policies and regulations and legal protection for police officers who are proven to use the manual ticketing system after the issuance of the National Police Chief's telegram letter. This research is a normative legal research, which is a type of research that examines documents with various secondary data such as court decisions, legal theories, laws, and regulations. The findings of this research indicate that the Government Regulation has a higher position than the Chief of Police's telegram letter. Therefore, members of the Indonesian National Police who are still detected conducting manual ticketing can obtain legal protection because National Police Chief Regulation No. 14/2011 explains that every member of Indonesian National Police who is a subordinate is obliged to refuse superior orders that are contrary to legal norms.
LAW ENFORCEMENT AGAINST PERPETRATORS OF UNLICENSED GOLD MINING CRIME IN SANGIHE ISLANDS
Authors: Susetyo Tony Budi , Amiq Bahrul , Prawesthi Wahyu
Published: June 2024

Law No. 4/2009 on Minerals and Coal prohibits unlicensed gold mining activities because they have a big potential impact on environmental damage. Therefore, strict law enforcement is needed against humans who are not aware of environmental damage. The main problem in this research is the criminal provisions and law enforcement against perpetrators of unlicensed gold mining in the jurisdiction of the Sangihe Islands Police, North Sulawesi. The objective of this research is to find out the law enforcement process against perpetrators of unlicensed gold mining crimes in the jurisdiction of the Sangihe Islands. The approach method used in this research is the sociological juridical approach method. The juridical sociological approach is a research approach that uses legal aspects (legislation and facts in the field) related to the subject matter to be discussed, associated with the reality in the field or examines the positive law of an object of research and sees the practices that occur there. There are many mining businesses in various regions in Indonesia that are managed by local communities. Unfortunately, although there are national regulations that regulate the mining business, there are still very many mines managed by the community that have the status of illegal mining because they do not have a license, either a Special Mining Business License (IUPK) or other permits.
THE LAW DEVELOPMENT IN INDONESIA UNDER SOEKARNO’S PRESIDENCY (1950-1966) AND NEW ORDER REGIME (1966-1990) AND ITS RELEVANCE TO NATIONAL LAW DEVELOPMENT
Authors: Sayuti Ageng Triganda , Simabura Charles
Published: June 2024

This research discusses the thoughts of Professor Soetandyo Wignjosoebroto as outlined in the book “Dari Hukum Kolonial ke Hukum Nasional” which discusses the development of socio-political dynamics in the development of law in Indonesia during the period of half a century (1840-1990). This research aims to identify the development of national law during the reign of President Soekarno, the development of national law during the reign of the New Order regime, and the relevance of the development of national law at the beginning of independence to the development of Indonesian law today. This is a normative juiridical research with statutory, case, comparative, and conceptual approach. The findings of this research indicate that the development of national law during the early years of independence was confronted with the desire to form a national law that was independent of colonial law and faced with legal certainty and development. The relevance of the law development at the beginning of independence with the current Indonesian law development suggests that law development cannot be separated from the existing values in the society.
PERFORMANCE OF BOOM CYLINDER REPAIR MECHANISM AND AUTO LUBRICATION SYSTEM OF EX 2500 HITACHI EXCAVATOR
Authors: Sianturi Maranata P. , Sihombing Rolando , Sembiring Jesayas
Published: June 2024

Excavators is one of the heavy equipment used to do transport, excavation, loading work that is operated using hydraulic energy. Excavator construction consists of three main parts, which consist of undercarriage, upper structure, and front attachment. During operation, one of the front attachment parts that has the highest performance is the boom cylinder actuator because it carries the entire load of the front attachment activity. The continuous work of the hydraulic boom cylinder will definitely suffer damage that cannot be avoided and can interfere with the performance of the unit. The damage is in the form of external leaks, internal leaks, scratches, and wear. This research aims to identify the types of damage, causal factors, and impacts caused by boom cylinder damage, explain the boom cylinder maintenance system and process, identify bends in the cylinder rod, and provide a reference price for repairing the Hitachi excavator boom cylinder. The methods used in this research are literature study, observation, and interviews. The results indicate that damage can be minimized by performing scheduled maintenance, such as selecting and replacing the right hydraulic oil and grease, cleaning the hydraulic oil cooler every 500 hours, replacing the oil filter every 250 hours according to the maintenance schedule, performing the inspection process during daily checks, operating the unit in the right way, avoiding modifications that can cause overloading, and performing oil analysis every 250 hours to ensure high availability of the unit as planned.
Instructions in package inserts intended for the use of medicines for dyspepsia and constipation during lactation
Authors: Roseno Danillo Alencar , Sempé Tatiana da Silva , Schmalfuss Thanyse de Oliveira , Giugliani Camila , Pizzol Tatiane da Silva Dal
Published: June 2024

Introduction: The safety and effectiveness of medication use during lactation are concerns for mothers and healthcare professionals. This research analyzes the instructions on the leaflets of medications commonly prescribed for dyspepsia and constipation, which aims to provide essential information to guide therapeutic decisions during this crucial period of motherhood. Objectives: To analyze the information in package inserts about contraindications of drugs for dyspepsia and constipation during breastfeeding, verifying whether these are consistent with scientific evidence. Methods: Drugs for dyspepsia and constipation were selected according to the Anatomical Therapeutic Chemical (ATC) classification and active registry in Brazil. The presence of contraindications for the use of medications in the health professional's and patient's package inserts was compared with the information in the technical manual of the Ministry of Health, Medications and Mothers' Milk, LactMed, UptoDate, Micromedex, Documento Científico da Sociedade Brasileira de Pediatria and Reprotox. Results: No information about use during breastfeeding was found in 20.0 and 24.3% of leaflets for dyspepsia and constipation, respectively. The agreement between the leaflets of medications for dyspepsia and the sources consulted was low (27.2% of the leaflets contraindicated the medication during lactation, while in the sources the percentage of contraindication varied from 0 to 8.3%). In relation to medicines for constipation, 26.3% of the leaflets contraindicated them, while in the sources the percentage ranged from 0 to 4.8%. Conclusions: The study pointed out that at least two out of every ten package inserts for dyspepsia and constipation do not provide adequate information on the use of these drugs in infants, and also shows low concordance between the text of the package inserts and the reference sources regarding compatibility of the drug with breastfeeding.
Screening for elder mistreatment in a Swiss emergency department: a prospective cohort study
Authors: Riedel Henk B. , Espejo Tanguy , Dreher-Hummel Thomas , Bingisser Roland , Nickel Christian H.
Published: June 2024

AIM OF THE STUDY: The mistreatment of older adults is a global and complex problem with varying prevalence. As there are no data on the prevalence of elder mistreatment in European emergency department populations, we aimed to translate and culturally adapt the Emergency Department Senior Abuse Identification (ED Senior AID) tool for German use, assess the positive screen rate for elder mistreatment with the German version, and compare characteristics of patients who screened positive and negative.
METHODS: To assess the prevalence of elder mistreatment, we created a German version of the ED Senior AID tool. This tool identifies intentional or negligent actions by a caregiver or trusted person that cause harm or risk to an older adult. Then, the German ED Senior AID tool was applied to all consecutively presenting patients aged ≥65 years at our academic emergency department in the Northwest of Switzerland from 25 April to 30 May 2022. Usability was defined as the percentage of patients with completed assessments using the German ED Senior AID tool.
RESULTS: We included 1010 patients aged ≥65 years, of whom 29 (2.9%) screened positive with the ED Senior AID tool. The patients who screened positive were older, more severely cognitively impaired, hospitalised more frequently, and presented with higher frailty scores than those who screened negative. Mortality up to 100 days after presentation was comparable in all patients (p = 0.861), regardless of their screening result. The tool showed good usability, with 73% of assessments completed.
CONCLUSION: This is the first prospective investigation on the prevalence of elder mistreatment in a European emergency department setting. Overall, 2.9% of patients screened positive using a validated screening tool translated into German.
TRIAL REGISTRATION: This study was registered with the National Institute of Health on ClinicalTrials.gov with the registration number NCT05400707.
Das Osmanische Reich
Authors: Howard Douglas A.
Published: June 2024

Von Osman I. bis Mehmed VI.: Die Geschichte der Osmanen und ihrer Dynastie Das Imperium der Osmanen kann die längste Zeitspanne ununterbrochener dynastischer Herrschaft der Weltgeschichte für sich beanspruchen: Ausgehend von kleinen Emiraten erstreckte sich das Reich schließlich über Afrika, Asien und Europa. Wie spielten auf diesem riesigen Staatsgebiet soziale, ökonomische und kulturelle Entwicklungen zusammen? Douglas Howard ist Professor für Geschichte. Die Türkei und das Osmanische Reich sind seine zentralen Forschungsgebiete. In diesem Sachbuch spannt er den Bogen über sechs Jahrhunderte, von den Anfängen um 1300 bis zur Abschaffung des Kalifats durch die türkische Nationalversammlung. Er beschreibt dabei ebenso die Politik der Kalifen wie das Leben der Menschen. Die osmanische Dynastie: Was zeichnet ihre Weltsicht aus und wie prägt sie ihre Herrschaft? Die Geschichte eines Weltreichs, die zugleich die Vorgeschichte der modernen Türkei ist Die Osmanen als Realpolitiker: Warum ihnen regionale Vielfalt wichtig war Ein Panorama der osmanischen Kultur: die enorme Bedeutung von Spiritualität, Kunst und Literatur Der Erfolgstitel jetzt als Taschenbuch in der Reihe wbg Paperback Alltag in einem Vielvölkerstaat: Vom Leben der Kalifen und der einfachen Leute Prof. Howard zeichnet nicht nur die Biografien der Herrscherfamilie nach. Er behandelt auch die Auswirkungen ihrer Herrschaft auf das Leben in der Hauptstadt und in den weit entfernten Provinzen. Wie sah der Alltag der Eliten und der einfachen Untertanen aus? Welche Rolle spielte die Religion und wie lebten Muslime, Christen und Juden miteinander? Wie war das Selbstverständnis der verschiedenen Völker hinsichtlich Identität und Loyalität? Dem Autor gelingt es, die Geschichte des Osmanischen Reichs mit der Kultur- und Geistesgeschichte des Landes zu einem großen Ganzen zu verknüpfen und genauso übersichtlich wie spannend darzustellen!
Hitlers heimliche Helfer
Authors: Urbach Karina
Published: June 2024

Schon von Standes wegen bewegten sie sich auf internationalem Parkett, wer hätte aber gedacht, dass so viele Aristokraten, Prinzen und Prinzessinnen auf diesem Parkett für Hitler unterwegs waren? Warum machte sich der Herzog von Coburg, Enkel von Queen Victoria, oder Prinzessin Stephanie von Hohenlohe mit den Nazis gemein? Karina Urbach gelangte an bisher unveröffentlichte Quellen, die bezeugen: Der Adel musste nicht erst von Hitler verführt werden. Bereits nach der Oktoberrevolution 1917 wendeten sich Adelige der extremen Rechten zu. Sie arbeiteten über Ländergrenzen hinweg und gewannen sogar Mitglieder des Hauses Windsor für den Nationalsozialismus. Ihr Einfluss war so groß, dass 1940 der Herzog von Windsor zu dem Schluss kam, Hitler solle Großbritannien bombardieren.
Grammatical Data in the Dictionary of Montenegrin National and Literary Language
Authors: Nenezić Sonja
Published: June 2024

Dictionaries are generally consulted to ascertain the meaning of a word. However, the meaning is inseparable from its grammatical features, which often determine it. Therefore, this article examines the type, scope, and method of presenting grammatical data in a comprehensive general dictionary. The aim is to analyze and ascertain the morphological and syntactic characteristics of all types of words recorded in what is currently the only such dictionary of the newly standardized Montenegrin language. Attention is also given to the applied metalanguage, representing a combination of transparent abbreviations and natural language. The initial hypothesis about the heavy reliance on the inherited Serbo-Croatian lexicographic practice is confirmed, but certain deviations from this tradition are also noted, which aligns with the dictionary's goal of presenting grammatical data more accessibly and comprehensively to its target users. Keywords: grammatical data, grammatical marker, general descriptive dictionary, Dictionary of Montenegrin National and Literary Language, Serbo-Croatian language dictionaries
Can topical applicatıons be an alternative to surgery in the treatment of chronic anal fissures?
Authors: Gazi Şahin Azad , Sayan İsmail , Alçı Erman
Published: June 2024

Introduction: Anal fissure, characterized by a painful ulcer in the anal canal, presents a significant medical challenge. While surgical approaches like lateral internal sphincterotomy (LIS) have been the gold standard for chronic anal fissures, they come with potential complications such as incontinence and abscess formation. In contrast, medical treatments, including topical glyceryl trinitrate and diltiazem, have emerged as alternatives, offering non-invasive options with potentially fewer complications. Method: In this retrospective study, we evaluated 136 patients treated for chronic anal fissures between June 2019 and December 2022 at Balikesir University Hospital, comparing surgical and medical interventions. The study encompassed demographic analysis, treatment modalities, complete recovery, recurrence rates, and side effects/complications. Statistical analyses, including logistic regression, were performed to assess the efficacy and risks associated with different treatments. Results: Our findings indicated a higher rate of complete recovery with surgical treatment (86.1%) compared to medical treatments (glyceryl trinitrate: 64.8%, diltiazem: 69.6%). However, no significant difference was observed in recurrence rates between treatment groups. Surgical intervention exhibited a higher incidence of complications such as incontinence and abscess formation, while medical treatments were associated with side effects like headache and gastrointestinal disturbances. Notably, diltiazem therapy showed outcomes comparable to other modalities, indicating its potential as an effective and safer alternative. Conclusion: Despite the favorable outcomes of surgical treatment, considerations of potential complications underscore the importance of tailored approaches. Prospective, randomized controlled trials with larger cohorts are warranted to further elucidate the efficacy and safety profiles of medical treatments in chronic anal fissures, facilitating informed decision-making in clinical practice.
Point-of-Care Ultrasound Findings in Occlusive Iliac Vein Thrombus During Pregnancy: A Case Report
Authors: Pettet Donald , Forrester John , Nelson Mathew , Bajaj Tanya
Published: June 2024

Introduction: Diagnosing deep venous thromboses and venous thromboemboli (DVT/VTE) in pregnant patients presents a unique challenge for emergency physicians. The risk of DVT/VTE increases during pregnancy, and the potential consequences of misdiagnoses are severe. Point-of-care ultrasonography (POCUS) is frequently a ﬁrst-line diagnostic imaging modality. However, recent studies have shown a high incidence of thromboses proximal to the common femoral vein during pregnancy, and these would not be visualized using compressive ultrasonography, which traditionally can only visualize thromboses distal to the femoral vein. Case Report: A 38-year-old female, 25-weeks primiparous, presented to the emergency department with a three-day history of left lower extremity swelling. Point-of-care three-point compression testing was used to evaluate for a DVT; however, no thrombus was visualized. Given high clinical suspicion, color and spectral Doppler testing were performed and demonstrated turbulent ﬂow and reduced respiratory variation in the common femoral vein. This prompted further additional testing for a proximal DVT using magnetic resonance venography, which revealed an occlusive left external iliac thrombus. The patient was subsequently started on daily subcutaneous enoxaparin and discharged home with close follow-up. Conclusion: Emergency physicians play a critical role in evaluations for the presence of DVT/VTE, particularly in pregnant patients. We endorse the use of POCUS with three-point compression testing, as well as color and spectral Doppler imaging, to help identify proximal DVTs in this patient population. This case report can aid physicians in the diagnosis of this pathological condition that if left untreated can have severe consequences.
APLIKASI BIOHERBISIDA EKSTRAK SERASAH DAUN BAMBU (Dendrocalamus sasper) UNTUK MENGHAMBAT PERTUMBUHAN GULMA SEMBUNG RAMBAT (Mikania micrantha
Authors: Novitasari Padia , Jatsiyah Venti , Ratnawati Hermanto Sarwendah , Kurniawan Tardi
Published: June 2024

Gulma sembung rambat (Mikania micrantha) merupakan gulma yang tumbuh di perkebunan kelapa sawit yang belum menghasilkan. Salah satu bahan baku yang dapat digunakan sebagai bahan pembuatan bioherbisida yaitu ekstrak serasah daun bambu (Dendrocalamus sasper L.) karena mengandung senyawa kumarin, flavonoid, antrakuinon, polisakarida, fenolik dan asam amino. Penelitian ini bertujuan untuk mengetahui apakah pemberian ekstrak serasah daun bambu dapat menghambat pertumbuhan gulma sembung rambat dan  mengetahui konsentrasi ekstrak serasah daun bambu yang efektif untuk menghambat pertumbuhan gulma sembung rambat. Penelitian ini menggunakan Rancangan Acak Lengkap (RAL) non faktorial,yang terdiri dari 6 taraf perlakuan konsentrasi K0 = Kontrol, K1 = 5%, K2 = 10%, K3 = 15%, K4= 25% dan K5 = 35 dengan 5 kali ulangan sehingga diperoleh 30 satuan percobaan dimana setiap sampel unit percobaan terdiri dari 3 sampel sehingga total jumlah keseluruhannya 90 sampel gulma terhadap pertumbuhan gulma sembung rambat dengan parameter pengamatan tinggi tanaman, jumlah daun, hari kematian, berat basah, bering kering dan panjang akar. Hasil sidik ragam bahwa aplikasi ekstrak serasah daun bambu memberikan pengaruh nyata terhadap tinggi tanaman, jumlah daun, hari kematian, berat basah, berat kering dan panjang akar. Konsentrasi ekstrak serasah daun bambu yang efektif menghambat pertumbuhan gulma sembung rambat adalah konsentrasi ekstrak serasah daun bambu 25%.
CLASSIFICATION OF DATA MINING TECHNIQUES WITH ITS APPLICATIONS
Authors: Vishwakarma Aditya
Published: June 2024

Data mining is an adjustment that analyzes massive amounts of abstracts to bare astute patterns. The cardboard examines a few abstracts mining methods, algorithms, and enterprises that accept acclimated abstracts mining technologies to enhance their operations with abundant success
IMPACT OF GLOBAL SOURCING IN SUPPLY CHAIN FUTURISTIC MANAGEMENT
Authors: Viswanathan Pallikkara
Published: June 2024

The practice of sourcing from the point of global in an inclined market for goods, materials, also the services, required across geographical boundaries have become an important futuristic aspect in concurrence with supply chain. Global sourcing often aims to be very explicit, on the global efficiencies on the delivery of the product, also on the requirement of the services in supply chain. The efficiencies in particular include low skilled labor, low cost raw materials, and minimum wastage. In the large number of information technology projects, also in service application, mobile apps, also in data base service are outsourced globally for more economic pricing. Global sourcing include hidden cost, in pricing, associated with different culture, with exposure to financial, also political risk, being for manufactured goods, which has the disadvantage of longer lead time, risk at ports, interrupting supply chain, also of difficulty in monitoring quality of product in supply chain. Global sourcing is the practice of sourcing materials, components, products, from the global market. Goods and services across geographical boundary in supply chain, in which is sourcing often aims to exploit global efficiency in delivery of product and service. In a global sourcing in futuristic management is that manufacturing cost, are generally lower, while business organization can often buy goods at a lower price. Global sourcing from international market aims to exploit global efficiency, such as lower price, cost of skilled labor, cheaper raw materials, and economy facing lower trade tariff. Global sourcing in futuristic management is the process that the organization buys the product it needs or requires from the any organization globally. The high tech products that are selected in the market are to be global sourcing and supply chain management. Supply chain global sourcing does simplifies the communication, optimizing the procedures between vendors, customers, thus making it easier for the development markets, to stay connected in any part of the global economy in supply chain
BLOCKCHAIN TECHNOLOGY IN MEDICAL SCIENCE
Authors: Ahmad Dr. Sharique , Anwar Subuhi
Published: June 2024

Blockchain technology has emerged as a revolutionary force in the healthcare industry, promising to transform medical science by enhancing security, transparency, and data management. The decentralized and cryptographically secure nature of blockchain offers unique advantages in managing medical records, clinical trials, drug supply chains, and patient care. This abstract explores the various applications of blockchain in medical science, delving into its benefits, challenges, and future potential
ROLE OF ARTIFICIAL INTELLIGENCE IN COMPUTED TOMOGRAPHY
Authors: Thidwar Mr. Rajdeep , Yadav Ms. Piyush
Published: June 2024

The efficiency and accuracy of CT imaging and radiology can be greatly enhanced by AI. To fully reap the benefits of AI in healthcare, it is crucial to address the remaining challenges as the field continues to evolve. By integrating AI into CT imaging and radiology, diagnoses and treatment planning can be improved in terms of speed, accuracy, radiation dose and efficiency. However, ensuring data quality, generalizability, and transparency is essential in order to fully harness the potential of AI in healthcare. It is crucial to acknowledge that AI serves as a means of aiding radiologists rather than substituting them. Radiologists hold a pivotal position in the interpretation of intricate imaging data, taking into account the clinical context and making well-informed judgments. AI supports their endeavours, amplifies productivity, and has the potential to improve patient outcomes. To guarantee the utmost quality of patient care, it is imperative to meticulously validate AI systems, consistently update them, and employ them alongside human proficiency. Addressing these challenges will be crucial in unlocking the complete potential of AI in CT interpretation and enhancing patient care, and quality CT Images as the technology progresses
THE WEREWOLF: AN EXPLORATION OF MYTH AND LEGEND
Authors: Jamuna Dr. J.
Published: June 2024

Some modern researchers have tried to explain the reports of werewolf behaviour with recognised medical conditions. Dr Lee llllis of Guy's Hospital in London wrote a paper in 1963 entitled On Porphyria and the Aetiology of Werewolves, in which he argues that historical accounts on werewolves could have in fact been referring to victims of congenital porphyria, Stating how the symptoms of photosensitivity, reddish teeth and psychosis could have been grounds for accusing a person of being a werewolf. This is however argued against by Woodward, who points out how mythological werewolves were almost invariably portray as porphyria victims. Others have pointed out the possibility of historical werewolves having been people with hypertrichosis, a hereditary condition manifesting itself in excessive hair growth. However, Woodward dismissed the possibility, as the rarity of the disease ruled it out form happening on a large scale, as werewolf cases were in mediaeval Europe. People with Down syndrome have been suggested by some scholars to have been possible originators of werewolf myths. Woodward suggested rabies as the origin of werewolf beliefs, claiming remarkable similarities between the symptoms of that disease and some of the legends. Woodward focused on the idea that being bitten by a werewolf could result in the victim turning into one, which suggested the idea of a transmittable disease like rabies. However the idea that lycanthropy could be transmitted in this way is not part of the original myths and legends and only appears in relatively recent beliefs. Lycanthropy can also be met with as the main content of a delusion, for example, the case of a woman has been reported who during episodes of acute psychosis complained of becoming four different species of animals
UNICYSTIC AMELOBLASTOMA
Authors: Patel Dr. Prachi , Patel Dr. Bhupesh , Tiwari Dr. Himani , Mehta Dr. Rina
Published: June 2024

Unicystic ameloblastoma (UA) is a monocystic lesion having odontogenic epithelium. UA arises from the epithelial remains of Malassez of Hertwig’s epithelial sheath. It usually affects men more than women and appears common in 20 to 30 years of age. Clinically, it is asymptomatic, although it can induce swelling and facial asymmetry by expanding the bony cortex and permitting soft tissue invasion. Chances of invasion and recurrence are more in this as compared to conventional ameloblatoma. UA has a well-defined, radiolucent, unilocular on radiographs, and histologically, it can be luminal, intraluminal, or mural, depending on the pathologic cavity characteristics. Most treatments depend on surgical excision of the lesion, which allows tumour removal with safe bone margins
MICROSURGERY : PRECISION IN ACTION
Authors: Jha Dr. Swati , Jain Dr. Sheena , Jolly Dr. Aishwarya , Deb Dr. Anisha
Published: June 2024

Microsurgical approach is a minimally invasive process that leads in faster healing and a better patient response. Inspection is a critical element of microsurgery that is completely lacking in the earlier surgical procedure. Isthmuses frequently cause treatments to fail; consequently, they must be found, cleaned, shaped, and filled with the same care as root canals. Almost all endodontic lesions can be successfully treated by adhering to a precise microsurgical regimen and carefully selecting patients. Endodontic surgery has evolved into microsurgery with strong illumination and magnification under the operating microscope, as well as the addition of several microinstruments. Endodontic surgery using microsurgical methods allows doctors to perform endodontic surgery with smaller osteotomies, shallow bevels, isthmus preparation, assessment of resected root surfaces, retropreparation in line with root canal, and precision in placement of new filling materials. Each patient's circumstance is unique, and they must be carefully evaluated to see if they are candidates for surgical intervention. The severity of the infection, the state of the surrounding tissues, and the patient's age are all factors to consider. Adopting the latest developments in endodontic microsurgery allows dentists to handle difficult cases and give their patients the best care possible
TYPE 3C DIABETES MELLITUS
Authors: S Dr. Hemadharshini. , V.M Dr. Vinodhini. , P Dr. Renuka.
Published: June 2024

Type 3C diabetes which is a secondary form of diabetes.It Includes that are brought on by an impairment in pancreatic endocrine function that are brought on by exocrine damage brought on by acute, relapsing, and chronic pancreatitis (of any aetiology), cystic fibrosis, hemochromatosis, pancreatic cancer,pancreatectomy.Type 3c diabetes is too difficult to diagnose, it frequently goes misdiagnosed and receives poor care.The main mode to reduce the risk of micro- and potential macrovascular consequences is by the control of hyperglycemia and to attain & maintain the HbA1c 7%.TPIAT is regarded as the only effective treatment for recurrent acute or chronic pancreatitis, with the primary goal of relieving pain and the reduction of narcotic use and frequent hospitalisations for pain exacerbations.Type 3c DM is becoming more common nowadays because individuals frequently confuse it with type 1 and type 2 diabetes due to a lack of diagnostic expertise
DEVELOPMENT AND EVALUATION OF A SELF-MICRO EMULSIFYING OMEGA-3 FATTY ACID DRUG DELIVERY SYSTEM USING FLAXSEED OIL
Authors: S Harer Priyanka , L Harer Sunil
Published: June 2024

Self micro-emulsifying drug delivery system is the mixture of oils, surfactants, and cosurfactants, which are emulsified in aqueous media under conditions of gentle agitation and digestive motility that would be encountered in the gastro-intestinal (GI) tract that leads improve the solubility, bioavailability and biocompatibility. Purpose of this work is to prepare self-microemulsifying drug delivery system (SMEDDS) to enhance the oral bioavailability and stability of linseed oil (Omega-3 fatty acid). Linseed contains very high amount of omega-3 fatty acid (55-60%). Solubility of linseed oil (Omega-3 fatty acid) was determined in various solvents. Based on screening for oil, surfactant and co-surfactant; Linseed oil, Cremophor RH-40 Surfactant, and Imwitor-988 Co-surfactant were selected. Pseudo-ternary phase diagrams were constructed to identify the efficient self-emulsification region and particle size distributions and zeta potential of the resultant microemulsions were evaluated. The release study of Omega-3-fatty acid from the SMEED formulation and marketed capsule formulation were compared, and shown to exhibit significantly higher release. Also GC chromatogram showed the better stability of omega-3-fatty acid in SMEED formation as compared to marketed capsule formulation. Our study demonstrated the potential and alternative formulation for efficient delivery of omega-3-fatty acid that contained in linseed oil
ARTIFICIAL INTELLIGENCE AND MENTAL HEALTH SOCIAL WORK
Authors: Varghese Febin Abraham , Monika M. Angel
Published: June 2024

Mental Health Social Work is the application of social work methods and practices across the entire spectrum of psychiatry. It encompasses a skill-based approach within psychiatric settings, blending the realms of art and science while connecting to various disciplines within social work. Approximately 1 in 4 people globally will experience a mental health disorder at some point in their lives. Common mental health disorders include anxiety disorders, depressive disorders, bipolar disorder, schizophrenia, and eating disorders. Social work, as a constantly evolving field of expertise, must progress in tandem with technological advancements. The futuristic addition to this progress is artificial intelligence, which has made significant inroads into the realm of social work. AI presents potential solutions that can enhance efficiency, aid in diagnosis, and improve treatment within the healthcare sector, even as it grapples with numerous challenges in its integration. In healthcare, AI aids in precise diagnostics and health monitoring, and language translation tools break down global communication barriers. AI, with its remarkable capabilities in data analysis, and machine learning, has the potential to revolutionize the way psychiatric social work is practiced and contribute significantly to improving mental health care outcomes. Artificial Intelligence is consistently drawing the attention of everyone due to its transformative potential across various aspects of daily life. This is an overview on the integration of AI into the domain of psychiatric social work that will delve into the various facets of this integration, including its potential benefits, challenges, and ethical considerations.
AN OVERVIEW OF BIOREMEDIATION FOR POLLUTED ENVIRONMENT
Authors: Palit Swagata
Published: June 2024

There has been a rise in environmental pollution across the world over the past decades because of various reasons. Bioremediation is the most popular and efficient cleaning mechanism that can get rid of toxic waste from the environment. Bioremediation is well regarded for eradication, degradation, detoxification, and immobilization of various hazardous materials and chemical wastes from the polluted environment with “all-inclusive action” of pathogens. The core concept of bioremediation is degradation and conversion of toxic pollutants into something less toxic. This process can be done in-situ and ex-situ as per various factors like nature of site, cost, pollutant concentration, and type. So, it is important to choose the right bioremediation technique. In addition, some of the mechanisms to develop bioremediation are bioaugmentation, bio-stimulation, biopiles, bioventing, and bio-attenuation. Bioremediation process can be conducted as per the environmental factors. It is the most economical, effective, and sustainable approach to control pollution. There are pros and cons of all bioremediation methods that will also be discussed in this chapter.
PROTEINOPATHIES: A REVIEW ON CURRENT SCENARIO AND THERAPEUTIC INTERVENTIONS
Authors: Gupta Nimisha , Waziri Dr. Farheen
Published: June 2024

There are certain neurodegenerative as well as non-neurodegenerative disorders whose characteristic feature is the presence of protein aggregates. The aggregates can be of different types, shapes, and sizes. These aggregates are harmful because they sequester the proteins and RNAs essential for cellular function. Protein aggregates found in these proteinopathies are thus an area of major interest in the scientific community. In recent years, scientists have tried to develop diagnostic and therapeutic measures targeting the protein aggregates. This review article aims to provide an overview of the advances that have been made in the last five years in terms of understanding of the protein aggregates found in the disease, its diagnosis, and its treatment. To achieve this, PubMed and Google Scholar were searched for reviews and research papers published from 2015-2020 using the following keywords: ‘protein aggregation’, ‘proteinopathy’, ‘protein aggregation disorders’ etc.
LINEAR DIFFERENTIAL EQUATION WITH FIXED COEFFICIENTS AND ITS APPLICATION
Authors: Dravid Dr. Rahul
Published: June 2024

In this chapter, we shall discuss a linear differential equation and its forms applied in many fields of engineering. Including the following sections • Definition of the Linear Differential Equation and Its solution. • The way to find a Complementary Solution • The way to find a Particular Solution • Simple Problems • Application • Data
EXISTANCE AND UNIQUENESS OF ϖ-CONTRACTION MAPPING USING CONTINUITY OF SOFT-T NORM UNDER SOFT FUZZY METRIC SPACES
Authors: Shinde Sopan Raosaheb , Pathak Dr. Renu Praveen
Published: June 2024

The primary goal of this manuscript to introduce the notion of Banach’s contraction principle and ϖ-contraction mapping in to the soft fuzzy metric space (SFZMS). Throughout this manuscript we taken under consideration absolute soft set, soft point as a restriction of our results and we successfully applied Continuity of soft-t-norm to newly developed ϖ-contraction mapping principle which admits existance and uniqueness of soft fiexed pints, Subsequently some illustrations are supplied to support our main contraction mapping principle. Our newly developed results are generalized version of some famous results from literature.
REFLECTIONS OF MINIATURE PAINTING IN INDIAN CULTURE; A COGNITIVE STUDY
Authors: Freya Krishna Mahima
Published: June 2024

Nature is the best known artist. In nature’s creation we see forms, but there is no out-line. The line is created by an artist. Miniature painting is an art of line. Miniature painting formally came to be known as a technique in the 17th Century AD, though it started its ovulation in the 9th century AD on palm leaves. Popularly painted subjects depicted court scenes, mythology and folklore under patronage of Indian maharajas, Indian Miniature painting, took an interesting twist under the colonial patronage from 1860s, with depiction of the common person and their life. Visually there was an amalgam of east and west, addition to a plain dull background in certain drawings. Bazaar art too gained a lot of popularity with the masses post partition in 1947. The focus and concern of my research is & quot;Towards a Practice-based study of miniature and calligraphic Lines from the ancient art of miniature painting to contemporary times is ; based on the completion of my practice-based National Fellowship, & quot;Junior Research Fellowship for Outstanding Artist in the Field of Culture Archive" by the Ministry of Culture. It is s an extension of a self initiated research that started in late 2014.
RECENT ADVANCES IN ENDODONTIC IRRIGATION TECHNIQUES
Authors: Nakate Dr. Pooja , Badole Dr. Gautam , Akotkar Dr. Aishwarya
Published: June 2024

Chemical and mechanical cleaning of root canal system has prime importance for complete disinfection. Sodium hypochlorite and chelating agents are most commonly used for root canal irrigation however it is less effective in apical third area. Activation of irrigating solution is necessary for cleaning of apical tiny area so that irrigation solutions must come into direct contact with the entire canal wall surfaces. Now various irrigation systems are available to activate the irrigation solution.
LIABILITY OF SELF-DRIVING CARS: CHALLENGES AND PROSPECTS IN THE ERA OF AUTONOMOUS VEHICLES
Authors: Aadhisha Muchala , Sai Sri Palisetty Yashoda
Published: June 2024

Every day, road accidents caused by human errors result in countless injuries and fatalities worldwide. Factors like distracted driving, impaired judgment, fatigue, and recklessness contribute to a significant portion of these incidents. Self-driving cars, equipped with a sophisticated array of sensors, cameras, and advanced algorithms, have the potential to drastically reduce the occurrence of such accidents. Unlike human drivers who may become fatigued or distracted, autonomous vehicles maintain constant vigilance, monitoring their surroundings and making split-second decisions based on real-time data. This capacity to consistently adhere to traffic laws, maintaining safe distances, and anticipate potential hazards offers a promising solution to the issues of human fallibility. Despite, the advantages deployment of self-driving cars also raises critical questions regarding liability and responsibility in the event of accidents or incidents. Self-driving cars, while promising, present a range of challenges like Malfunctions, sensor errors, and system failures might occur, leading to accidents or vehicle shutdowns. Ethical dilemmas can arise when programming AI to make life-or-death decisions in accidents. It is also complicated the determination of responsibility in case of accidents involving autonomous vehicles. Job displacement is also a concern, and regulatory frameworks struggle to keep up with evolving technology. Additionally, cybersecurity vulnerabilities could expose vehicles to hacking, raising questions about data privacy and overall system integrity. Hence, there should be some properlegal policy and regulations to face these difficulties. So, this research paper provides an overview of the evolution nof autonomous vehicles and the levels of automation of self-driving car systems. Subsequently, it examines the diverse stakeholders involved in the development, manufacturing, and deployment of autonomous vehicles. An in-depth analysis of the legal framework governing self-driving cars in different jurisdictions. Furthermore, we examined the case studies and real-world incidents to understand the practical application of liability principles. The paper concludes by proposing potential solutions and recommendations to address liability concerns surrounding self-driving cars. It discusses the importance of establishing standardized regulations that foster innovation while ensuring public safety. Overall, this research paper contributes to the ongoing debate on the liability of self-driving cars, aiming to shed light on the challenges and opportunities presented by autonomous vehicles and to assist policymakers, industry stakeholders, and the public in responsibly and safely navigating this transformative technology.