bluuebunny/crossref_metadata_2025 huggingface dataset:
Post-fire properties of lightweight 3D printed concrete containing expanded perlite
Authors: Azimi Zahir , Mousavi Moein , Bengar Habib Akbarzadeh , Javadi Akbar A.
Published: December 2023

There has been an increase in construction with three-dimensional (3D) printing technology but 3D printed (3DP) structures also require weight reduction similar to conventional reinforced concrete structures. In addition, the behaviour of this type of structure against fire needs to be investigated. The number of printed layers and the time gap between layers for the 3DP specimens were among the variables examined. The test results demonstrate that as the replacement percentage of natural sand (NS) with expanded perlite (EP) increased, at 25% volume of replacement, the interlayer bond strength increased on average by 18.6%, while at the highest replacement level, of 75%, the strength decreased on average by 5.8%. Additionally, by incorporating EP, the compressive and flexural strengths of 3DP specimens declined on average from 9% to 29.7%, and from 39.3% to 49.3%, respectively. As the replacement level of NS increased, residual compressive and flexural strengths increased after exposure to 800°C. Furthermore, it was demonstrated that exposure to high temperature had the least effect on interlayer bond strength, whereas it significantly reduced the compressive and flexural strength. The results show that increasing the time gap between layers reduced interlayer bond strength and flexural strength while negligibly affecting compressive strength.
PARTICIPATION OF THE ACCUSED IN THE TRIAL
Authors:   International University of the Kyrgyz Republic, Tenizbek kyzy Nazira , Akhmatov Aibek ,   International University of the Kyrgyz Republic
Published: December 2023

In the trial, the accused is a participant on the part of the defense, who has all the rights of a party in the process and has the right to participate in the study of all the evidence presented by the participants in the trial during the investigation of the circumstances of the case. In carrying out his defense, the accused can not only actively participate in the trial, but also take a passive position. On the other hand, his testimony is evidence in a criminal case, including an accusatory one. In this case, "the evidence base of the prosecution can be formed with the participation of the accused himself," while the participation of the accused in the study and presentation of evidence should not be made dependent on his consent or refusal to testify. In foreign practice, in particular in the criminal proceedings of England and the USA, the testimony of the accused is a kind of testimony that has certain specifics. This is manifested in the following. In the United States, the accused can: refuse to testify; act as a defense witness without an oath (in this case, his testimony is not given the force of evidence); testify under oath. In England, the accused must either remain silent (refuse to testify), or act as a witness. Both in England and in the USA, if the accused decides to testify, he is interrogated as a witness under oath, may be cross-examined when the prosecution, the court will be able to ask questions incriminating the accused of committing a crime, he is also responsible for giving false testimony.
CH. AYMATOV AND INTERCULTURAL RELATIONSHIPS (BY THE EXAMPLE OF CH. AITMATOV’S NOVEL “AND THE DAY LASTS LONGER THAN A CENTURY”)
Authors:   National Academy of Sciences of the Kyrgyz Republic, Tokoeva Zhumabubu
Published: December 2023

The main purpose of the article is to identify intercultural relationships in the work of the great Kyrgyz writer Chingiz Aitmatov based on the study of dramatizations and adaptations of Aitmatov's novel "And the Day Lasts Longer than a Century" on the world stage and in the cinema of neighboring countries and to find similarities and differences in screen and stage productions of this novel. The article uses such research methods as comparative typological and comparative historical methods, in addition, such research principles as the principles of general and singular, induction and deduction, historical and logical are used. The article analyzes the features of film adaptations and dramatizations of Ch. Aitmatov’s novel “And the day lasts longer than a century” in world culture: Russian (Moscow Drama Theater named after E. Vakhtangov), Lithuanian (Lithuanian Youth Theatre), Turkmen (“Turkmenfilm”), Uzbek (“ Uzbekfilm) and Kyrgyz (“Kyrgyzfilm”) scenes and on the screen, according to the comparative typological method, the similarities and differences of these productions, the strengths and weaknesses of dramatizations and screen adaptations in the context of intercultural relationships, as well as the features of the actors’ performance, especially the interpretation of the image of the main character Edigey Russian actor M. Ulyanov, Lithuanian actor A. Latenas; as well as the image of Mankurt by the Turkish actor Takir Tarzhan in the Turkmen film "Mankurt" and the Kyrgyz actress A. Azhibekova; their originality and skill, as well as some shortcomings and omissions in the interpretation of images.
DIGITALIZATION OF CIVIL JUSTICE IN THE EUROPEAN UNION
Authors:   in International Civil Litigation Thessaloniki Bar, Anthimos Apostolos
Published: December 2023

The paper presents briefly the efforts of the European Union to digitalize the field of judicial cooperation in civil and commercial cases. Following a short introduction, it refers to the new era of digital transition, which was kickstarted by the 2020 Communication of the Commission. Data from the EU Justice Scoreboard and updates in the legislative field are shedding light to the steps taken. The e-codex system and aspects of digitalization in specific EU Regulations in the field of civil and commercial proceedings are scrutinized, with the aim to give insight to the forthcoming developments in the EU. This paper was presented at the International Legal Workshop “Strengthening the Rule of Law through E-justice” (October 29-30, 2021, Bishkek, Kyrgyzstan) and published with support of Volkswagen Foundation (Germany).
Urbanização em assentamentos precários: o caso do Assentamento Carrapicho em Várzea Grande – MT
Authors: Moraes Geovane da Silva , Ravache Rosana Lia , Godoy Jeane Aparecida Rombi de , Salmoria Fabiana Zili
Published: December 2023

Este estudo aborda ocupações irregulares em área de preservação ambiental no Assentamento Carrapicho, em Várzea Grande - MT. A pesquisa tem como objetivo compreender a vulnerabilidade socioambiental da população local e identificar possíveis meios de intervenção para melhorar a qualidade de vida dessas comunidades. Além de discutir a relação histórica entre rios e cidades, a importância da conservação das áreas úmidas, a falta de políticas públicas coerentes para lidar com a ocupação irregular, a degradação ambiental e a necessidade de intervenções para melhorar a situação das comunidades vulneráveis ​​em áreas de preservação permanente. O método observacional foi utilizado para analisar a situação atual da cidade de Várzea Grande e do Assentamento Carrapicho e seu entorno. No âmbito espacial, observamos infraestrutura urbana inadequada, moradias autoconstruídas e com baixo padrão de construção, além de muito abandono e descaso por parte do poder público.
EU Carbon Border Adjustment Mechanism: Legal Challenges and Relevance in Light of the Current Sanctions Regime
Authors: Петрова Татьяна Петровна
Published: December 2023

Carbon Border Adjustment Mechanism (СBAM) is one of the European Union's Green Deal initiatives aimed at creating a “climate neutral” economy. The specific feature of this mechanism is the creation of additional costs when importing goods from non-EU countries, the production of which is associated with emissions of large amounts of greenhouse gases. The measure implies the reporting of carbon emissions amount and the sale of CBAM certificates depending on the amount of carbon emissions resulting from the production of imported goods. The author of the article analyses the dynamics of CBAM legal framework development as well as challenges that CBAM may face following its entry into force given the current trade restrictions introduced within the sanctions regime against Russia. The article also addresses challenges to CBAM in terms of its consistency with WTO law. The conclusion is made that new obligations for EU importers imposed by CBAM together with import bans and trade restrictions against the former major exporter of CBAM-covered goods to the EU would be very burdensome for EU importers. Furthermore, the compatibility of CBAM in its current form with WTO law non-discrimination standards is questionable; CBAM has been subject to criticism by the WTO members that are likely to be affected by the measure. This explains the recent shift of CBAM entry into force from January to October 2023 and could be a ground for further adjustment of CBAM rules.
Исполнение актов Суда Евразийского экономического союза: обзор первых проблем и путей их решения
Authors: Мысливский Павел Петрович
Published: December 2023

Суд Евразийского экономического союза — активный и востребованный международный судебный орган, работа которого нацелена на обеспечение единообразного применения права Евразийского экономического союза — интеграционного объединения России, Беларуси, Казахстана, Кыргызстана и Армении в сфере экономики. По существу рассматриваемых дел и в рамках своей компетенции данный судебный орган вправе выносить два вида судебных актов — консультативные заключения и решения — которые исполняются с разной степенью успешности. Так, если рекомендательные консультативные заключения воспринимаются акторами интеграции и, как правило, исполняются, то с обязательными решениями ситуация не столь благоприятная, поскольку действующее нормативное регулирование предусматривает существенную степень дискреции спорящих сторон в этом вопросе. В настоящей статье автором выявляются проблемы, возникавшие в контексте исполнения решений Суда: в частности, рассмотрена актуальная практика Суда по делам, в которых заявителями выступили работающие в сфере угольной промышленности российские компании, а также компании, привлеченные к ответственности за предполагаемое нарушение антимонопольного права Союза. Статья содержит обзор правовых позиций Конституционного и Верховного Суда Российской Федерации по вопросу учета практики Суда Евразийского экономического союза при отправлении правосудия национальными судами. Автор констатирует: основываясь на Статуте Суда, высшие судебные инстанции исходят из того, что действие правовых позиций в правовой системе России не самостоятельно и зависит от исполнения решения Суда Евразийской экономической комиссией. Кроме того, в статье рассматривается практика Конституционного Суда, сложившаяся ввиду закрепленной в Конституции невозможности признания решений Суда в качестве нового обстоятельства для целей пересмотра вступивших в силу судебных актов национальных судов. Автор предлагает варианты совершенствования исполнения решений Суда, в том числе путем комбинирования судебных процессов в Суде и национальных судах, реформирования национального процессуального законодательства с целью придания практике Суда статуса нового обстоятельства для целей пересмотра судебных актов, вступивших в законную силу, создания механизма мониторинга исполнения решений и консультативных заключений Суда, а также установления мер ответственности международных служащих за ненадлежащее исполнение решений Суда.
De Galatees a Ventafocs: les transformacions d’Eliza Doolitle i Dolores Mendoza
Authors: Gort I Paniello Marta
Published: December 2023

El motiu de la transformació de la figura femenina gaudeix d’una vasta trajectòria literària i es remunta al mite de Pigmalió recollit a les Metamorfosis, d’Ovidi, en el qual l’estàtua (Galatea) esdevé una dona de carn i ossos gràcies a la intervenció de la deessa Venus. Pel que fa a la literatura popular, una mutació similar es troba a la Ventafocs, la qual pateix una transformació física gràcies als poders màgics de la seva fada padrina. Pigmalió i La salvatge són dues reinterpretacions contemporànies del mite de Pigmalió que recullen, també, elements de la Ventafocs; aquest article se centra en la comparació del personatge de la Ventafocs amb les protagonistes d’aquestes dues obres inspirades en el mite de Pigmalió: Eliza, de Pygmalion, de George Bernard Shaw (1916), i Dolores Mendoza, de La salvatge, d’Isabel-Clara Simó (1993). Les dues protagonistes contemporànies muten en ser manipulades pels seus respectius Pigmalions, els quals ara són homes mortals i no tenen poders sobrenaturals. Aquesta recerca pretén analitzar, des d’una perspectiva de gènere, el tractament de les figures femenines tot parant atenció als paral·lelismes i dissimilituds presents entre les obres analitzades, la qual cosa, a més, posa també de relleu la pervivència dels mites clàssics i de la cultura popular en les narracions contemporànies.
Variations in Folkloristic Discourse in the Nineteenth-Century Press: Cecilia Böhl de Faber (1796–1877), Joseph Mainzer (1801–1851), Adolf Glassbrenner (1810–1867)
Authors: Schwab Christiane
Published: December 2023

This article highlights the connections between the production of folkloristic knowledge and expanding print markets in mid-nineteenth-century Europe. Looking at folkloristic writings from diverse geographical and social contexts, the article primarily focuses on the diverse socio-political and aesthetic sensitivities attached to the increased public interest in popular traditions. While Cecilia Böhl de Faber promoted a strongly idealizing and conservative view of the lower classes of the Spanish countryside, Joseph Mainzer’s works published in the French press addressed the creative potential of collective singing in urban contexts, and Anton Glassbrenner endeavoured to illustrate the democratic spirit of the lower classes in Berlin. The article shows that although all three authors promoted the exoticization and aestheticization of the ostensibly “authentic” habits, tales, and speaking modes of “the folk”, their views on the role of the lower classes within the social structure differed significantly. Keeping in mind the importance of mass media in enforcing collective conceptions of reality and political identity throughout the nineteenth century, this article creates new perspectives on the production of folkloristic knowledge within a broad socio-medial and political context.
A Multimedia Artist in an Ever-changing World: An Interview with Samit Basu
Authors: Marino Elisabetta
Published: December 2023

A filmmaker, a comics writer, a short-story author, and a novelist, Samit Basu is unquestionably a wide-ranging artist and one of the most interesting voices in contemporary Indian speculative fiction. Born in Kolkata in 1979, he earned a degree in Economics before dropping out of the Indian Institute of Management, Ahmedabad, to pursue a writing career. He furthered his education in London, where he took a course in broadcasting and documentary filmmaking at the University of Westminster. He is now based in India and works between Delhi and Mumbai. He has also penned children’s and young adults’ narratives, as well as being a columnist and essayist.
Counting Cells Using Cellaca MX v1
Authors: Sabic Ksenija
Published: December 2023

WIP
Automated 96 well plate based protein reduction and alkylation using a Beckman Biomek™ NxP workstation v1
Authors: not provided ronan.ocualain
Published: December 2023

Sample preparation for mass spectrometry analysis involves numerous liquid transfer steps. These include sample lysis, protein extraction, solubilisation, estimation, reduction and alkylation, normalisation, clean-up, enzymatic digestion, and desalting. Adapting these steps onto an automated workstation can increase efficiency, throughput, and reduce coefficients of variance (%CV) thereby providing reliable reproducible data for statistical comparisons. This protocol is part of a modular collection for the processing of biological samples for proteomics.
Protocol for Medication Possession Ratio (MPR) Calculation v1
Authors: Rodrigues Moreira Pryscila
Published: December 2023

The Medication Possession Ratio (MPR) provides an estimate of patient adherence based on the actual possession of medications. It is a metric that offers crucial information to assist in the development of strategies for the proper management of chronic diseases, such as Chronic Myeloid Leukemia (CML). RStudio is a free, open-source software maintained by an active community of developers, ensuring frequent updates and specialized packages in the healthcare domain. This software can be easily integrated into the practices of healthcare professionals for MPR calculations, optimizing their activities and allowing more time for direct patient care. In this context, a protocol was developed using the R programming language for MPR calculation, utilizing a spreadsheet with Tyrosine Kinase Inhibitor dispensation data. This script provides flexibility for MPR calculations to be applied to any chronic disease.
Visium CytAssist FFPE v2 -- University of Minnesota TMCs v2
Authors: J Niedernhofer Laura
Published: December 2023

The Visium CytAssist Spatial Gene Expression for FFPE assay is designed to analyze mRNA in tissue sections derived from formalin fixed & paraffin embedded (FFPE) tissue samples. The Visium CytAssist instrument requires a glass slide with intact tissue sections as input. Tissue sections are processed with Visium Spatial Gene Expression assay performed by the University of Minnesota Imaging Center and sequenced by the University of Minnesota Genomics Center.
Aspek Psikologi Sosial dalam Dongeng Nyi Kalimar Bulan
Authors: Ramadhani Annisa , Suherman Agus
Published: December 2023

Latar belakang penelitian ini adalah untuk mengungkap psikologi sosial yang terdapat dalam karya sastra Sunda dengan cara mendeskripsikan struktur cerita dan aspek psikologi sosial yang terdapat dalam dongeng Nyi Kalimar Bulan. Penelitian ini menggunakan pendekatan kualitatif dengan metode deskriptif-analitik. Sumber data dalam penelitian ini adalah dongeng Nyi Kalimar Bulan karya Usep Romli. Teknik yang digunakan dalam penelitian ini adalah studi pustaka. Hasil penelitian ini menunjukkan bahawa struktur cerita dongeng Nyi Kalimar Bulan meliputi tema, alur, tokoh, latar, sudut pandang, dan amanat, serta aspek psikologi sosial yaitu berupa pikiran sosial, pengaruh sosial, dan hubungan sosial. Aspek pikiran sosial terkandung dalam dunia sosial, penilaian sosial, dan sikap. Aspek pengaruh sosial meliputi genetik, gender, persuasi, dan pengaruh kelompok. Aspek hubungan sosial meliputi prasangka, agresi, ketertarikan, keintiman, menolong, dan konflik. Kesimpulan penelitian ini adalah bahwa dongeng Nyi Kalimar Bulan mengandung aspek psikologi sosial yang dapat dibandingkan sekaligus dijadikan cerminan kehidupan.
A Monte Carlo study on the size and power of panel unit root tests
Authors: Mravak Ivana
Published: December 2023

The aim of this paper is to explore the properties of various panel unit root tests in terms of their power and size regarding different panel data structures, with a special focus on small data samples. In particular, different values of the cross-sectional and time dimensions for both heterogeneous and homogeneous data settings with intercept and with and without time trend are observed. We examine and compare the results of five commonly used first-generation panel unit root tests: Levin, Lin and Chu test, Im Pesaran and Shin test, Harris–Tzavalis test, Breitung test and a Fischer type test. The results are derived using Monte Carlo simulations and show that all the observed panel unit root tests suffer from a serious lack of power and tend to either over or under reject the null hypothesis when the time dimensions are small. It is evident that the results of conducting panel unit root tests for data with T<30 are erroneous and unreliable, and it is therefore concluded that panel unit root tests should not be conducted for such samples in the first place. This is even more pronounced when there is a time trend or heterogeneity.
A new search direction for full-Newton step infeasible interior-point method in linear optimization
Authors: Kheirfam Behrouz
Published: December 2023

In this work, we investigate a full Newton step infeasible interior-point method for linear optimization based on a new search direction which is obtained from an algebraic equivalent transformation of the central path system. Furthermore, we prove that the proposed method obtains an ε-optimal solution to the original problem in polynomial time.
Tradition navigating transformation
Authors: Niehaus Heinrich
Published: December 2023

A tradition concept that does not sufficiently reckon with the problem of transformation, opens itself to two opposite dangers: the loss of openness through refusing any change; and the loss of integrity through surrendering assertibility to relativism. This article examines Alasdair MacIntyre’s tradition concept and brings it into conversation with a selection of Reformed scholars, hoping to instil, by its integration, a philosophical robustness in in the Reformed tradition’s thinking about tradition per se and its transformation, so that both integrity and catholicity might be maintained. This article ultimately argues for a congruence between MacIntyre’s tradition concept and the Reformed dictum ecclesia reformata semper reformanda est secundum verbum Dei and shows that the vitality of the tradition is not tied to an absence of argumentation, but rather to the presence of its virtues in these disputations. This may potentially alleviate anxieties in the South African Reformed churches about current arguments and transformations, and help guard against losses of integrity and openness, holiness and catholicity.
Missionale mobiliteit
Authors: Niemandt Nelus
Published: December 2023

Hierdie navorsing fokus op missionale mobiliteit. Missionale mobiliteit verwys in die algemeen na ’n missionale grondhouding wat dui op openheid, die vermoë om grense te oorskry en die bereidwilligheid om nuwe terreine te verken. Gestuurdes (sendelinge) is uit die aard van die missionale opdrag eerder handelaars as hekwagters, eerder mobiel as staties. Gestuurdes reik uit na ander, verwelkom vreemdelinge, eet wat aan hulle voorgesit word en skuif grense. Hierdie missionale grondhouding word in dié navorsing in verband gebring met die werk van predikante, die gereformeerde kerkregtelike verstaan van die verhouding tussen ’n predikant en ’n gemeente en die waarde van mobiliteit. Daar word aandag gegee aan die verband tussen missionale ekklesiologie en mobiliteit deur te verwys na die volgende aspekte: (1) Stephan Paas se kritiek op beweging en mobiliteit by geïnstitusionaliseerde kerke; (2) die belang van innovasie en grensverskuiwing as missionale grondhouding; (3) die rol van veerkragtigheid en aanpasbaarheid; (4) die wisselwerking tussen liminaliteit en stagnasie en (5) die rol van roeping in ’n predikant se koppeling aan ’n spesifieke gemeente. Die Protestantse Kerk in Nederland (PKN) se insigte en praktyke m.b.t mobiliteit van predikante word as ’n gevallestudie van ’n gereformeerde benadering tot mobiliteit voorgehou. Die navorsing word afgesluit deur die insigte te integreer en toe te pas op die situasie in die NG Kerk. Daar word aandag gegee aan die missionale fokus in die NG Kerk, die beroepstelsel en die uitdagings met betrekking tot die vestiging van ’n mobiliteitskultuur.
Model of Wave Transformation of a Decaying Trend of the COVID-19 Epidemic
Authors:   St. Petersburg Federal Research Center of the Russian Academy of Sciences, Saint Petersburg, Russian Federation, Perevaryukha A. Yu.
Published: December 2023

The COVID-19 pandemic in 2023 can be divided according to characteristics into groups of regional epidemics. Local processes demonstrate oscillatory dynamics in the form of special forms of oscillations. COVID waves and peaks cannot be considered classic damped relaxation oscillations. Often, the damping amplitude of infection waves formed after the initial outbreak again turns into an extreme peak. The reasons may be effects after crisis events: mass infections and/or an increase in virulence of a new strain that evades vaccine immunity. Using simulation tools, we analyzed a number of variants of epidemic dynamics with sudden changes. We have identified special important epidemic scenarios for the sudden occurrence of a short wave and computationally investigated on the basis of the proposed nonlinear equations with a deviating argument as the most likely development option for a given parametrically simulated situation. Each COVID outbreak is a positive feedback loop: the more infections, the higher the likelihood of further mutations in the virus and strains evading antibodies. At the end of 2023, after a long summer minimum, the incidence rate resumed due to strains of the new Omicron branch of BA.2.xx "Pirola". Keywords: modeling of oscillating epidemic dynamics, attenuation of infection waves, models with destruction of
Algorithm for Recognizing an Underwater Pipeline from Stereo Images
Authors:   Institute of Automation and Control Processes of the Far East Branch of the Russian Academy of Sciences, Vladivostok, 690041, Russian Federation, Bobkov V. A. , Morozov M. A. ,   Institute of Automation and Control Processes of the Far East Branch of the Russian Academy of Sciences, Vladivostok, 690041, Russian Federation, Shupikova A. A. ,   Institute of Automation and Control Processes of the Far East Branch of the Russian Academy of Sciences, Vladivostok, 690041, Russian Federation
Published: December 2023

The problem of recognition of an underwater pipeline (UP) from stereo images using an autonomous underwater robot (AUV) is considered in relation to the initial position of tracking the UP, or to situations where the previous section of the UP is hidden by interference (submerged in the ground, hidden by algae, etc.). The final result of the identification of the UP section, visible by the stereo camera, is the calculation of its center line and the detection of the relative position of the AUV and UP in the camera coordinate system. The article proposes a recognition method based on the selection of visible UP boundaries (contours) on vectorized images of a stereopair. At the stage of vectorization, noise is eliminated, illumination is equalized, and the image is processed using the Canny method to obtain a binary image. The construction of UP contours is performed using the algorithm proposed by the authors, which is a modification of the Hough method. The main feature of the proposed algorithm is a relatively high performance due to a multiple reduction in the amount of information being processed. Reducing the volume of processed data is done by pre-sorting the line segments in the vectorized image, and by optimizing the computational scheme in the algorithm. The experiments also showed that the algorithm can detect the visible boundaries of the UP on blurry, non-contrasting images. The algorithmic basis of the method is described in detail, including: — search and construction of the most reliable UP boundaries using the method of the integral contribution of the line segments to the line formation; generation and selection of point features belonging to the surface of the UP (due to the constructed contours); calculation of the 3D direction of the center line; calculation of the center line of the visible section of UP; —calculation of the AUV position parameters relative to the UP required for the AUV control system. The centerline calculation is performed using the least squares method using point features belonging to the surface of the UP. The performed computational experiments on virtual scenes using the real texture of the seabed confirm the operability of the implemented approach and the possibility of its application for the inspection of underwater infrastructure.
Estimating the Cardinality of Queries Based on a Sample from a Full Outer Join of Tables
Authors:   Bauman Moscow State Technical University, Moscow, 105005, Russian Federation, Grigorev U. A.
Published: December 2023

Cardinality estimation (CardEst) plays an important role in creating high-quality query execution plans in the DBMS. In the last decade, a large number of methods have been developed: traditional methods (histograms, samples), machine learning methods based on queries or data. But all of them are based on different restrictions and assumptions, and the cardinality estimation with their help worsens with an increase in the number of joined tables. The article proposes two new methods based on the theory of approximate calculation of aggregates and allowing to remove most of the restrictions. Method 1 fetches blocks after executing the subqueries of the original query and does not require a preliminary analysis of the filter conditions. The condition for joining tables can be arbitrary (not necessarily the equality of attributes). Method 2 allows you to calculate the probabilities of reading blocks based on the metadata accumulated in the process of populating the database. Metadata takes up little memory, and the overhead of maintaining it is low. Method 2, in contrast to method 1, takes into account the true cardinality of the connection of neighboring blocks in the sample obtained from metadata. Therefore, the prospect opens up for a more accurate assessment of the cardinality of joining a large number of tables. Method 1 (EVACAR method) is implemented and compared with modern machine learning methods BayesCard, DeepDB, FLAT on a special STATS test. The results of the experiments confirmed the effectiveness of the EVACAR method. The EVACAR method is more accurate or its maximum q-error is comparable to machine learning methods for 75-88 % of evaluated queries (subplans). In the future, it is planned to implement the 2nd method for assessing the cardinality of queries.
EVALUATION OF SECRETED FRIZZLED-RELATED PROTEIN-2 METHYLATION STATUS IN PATIENTS WITH CHRONIC MYELOID LEUKEMIA
Authors: Tahir Mohammed , Mohamad Dlnya , Hamid Mohammad
Published: December 2023

BackgroundChronic Myeloid Leukemia (CML) is a myeloproliferative disorder defined by the chromosomal translocation (t) (9;22) encoding for the BCR-ABL fusion gene. Tumor development and progression may be affected by hypermethylation of promoter regions of certain genes. Secreted Frizzled-Related Proteins (SFRPs) genes produce Wnt signaling antagonists, and their epigenetic silencing has been detected in multiple types of leukaemia. While epigenetic silencing has been broadly reported for SFRPs, SFRP2 is a family member less studied in leukaemia.
ObjectivesTo evaluate SFRP2 gene methylation patterns in CML patients compared with healthy individuals.
Materials and MethodsSodium bisulfite was applied to the extracted DNA from blood samples of 75 CML patients and 25 healthy subjects who served as the control group. The DNA was then analyzed by methylation-specific high-resolution melting (MS-HRM) using specific primers for the SFRP2 gene in promoter sequence.
ResultsForty-five out of 75 CML patients investigated were shown to have SFRP2 methylation percentages between 50% to 100%, whereas 19 out of 25 healthy subjects had a methylation level of less than 50%.
ConclusionThe current study demonstrated that SFRP2 promoter hypermethylation exists in CML, as in several other solid tumours. Hence, methylation of this gene may play a part in initiating leukemogenesis.
Investigating the current state of the Russian market for drugs treating infectious and inflammatory conditions of oral cavity and oropharynx to demonstrate the need for new drug development
Authors: Zvereva V. I. , Dzhavakhyan D. R. , Dul V. N. , Bobyleva V. S. , Markaryan A. A. , Morkovin E. I. , Kurkin D. V. , Dzhavakhyan M. A.
Published: December 2023

Objective: to assess the relevance and commercial prospects of bringing to market a drug for the local treatment of infectious and inflammatory diseases of oral cavity and oropharynx.Material and methods. The objects of the study were the drug nomenclatures in the State Register of Medicines, the Register of Medicines of Russia, as well as data from the Federal Service for Surveillance in Healthcare. The analysis of scientific publications in the field of marketing research of drugs, found in eLibrary.ru and PubMed/MEDLINE databases was carried out. For analyzing the structure and marketing research of drugs in the study group, specific methods of information retrieval, content analysis, description, data aggregation, ranking, data grouping method, system approach, as well as such methods of marketing analysis as determining the breadth and depth of the assortment, the renewal index, the vital importance index, SWOT analysis (strengths, weaknesses, opportunities, threats) were used.Results. The assortment of drugs for the local treatment of oral cavity and oropharyngeal infectious and inflammatory diseases was structured by the nature of the active substance, type of dosage form, and country of origin. The main trends in the development of the market of drugs of this group were identified. An analysis of the range of drugs using marketing research methods made it possible to establish the breadth and completeness of the range. The calculated renewal and vitality indices confirmed the relevance of developing new drugs with the considered pharmacotherapeutic action.Conclusion. The study revealed the main trends in the development of the market of drugs of the action in question. The SWOT analysis showed a possible strategy for developing and launching a new drug on the market.
The effects of the Pilates method in individuals after stroke: a systematic review with meta-analysis
Authors: Kiefer Kênia , Alvim Scianni Aline , Guimarães da Silva Lívia Carolina , Avelino Patrick Roberto , Coelho de Morais Faria Christina Danielli
Published: December 2023

Background: Pilates has shown significant effects in post-cerebrovascular accident (CVA) patients. Objective: To carry out a systematic review with meta-analysis, investigating the effects of the Pilates method in post-stroke individuals. Methods: An electronic search was performed using an optimized strategy in the Medline, CINAHL, SPORTDiscus, Web of Science, LILACS and PEDro databases, plus a manual search. Clinical trials that used the Pilates method in post-stroke rehabilitation, in functionality outcomes, were included. Studies were reviewed by two independent reviewers. Methodological quality was assessed using the PEDro scale. Results: Seven studies were included. The results of the meta-analyses showed that Pilates was effective in improving mobility (-3 seconds; CI 95% -4 to -1; p=0.009), assessed by the Timed Up and Go, and quality of life (SMD 1 .1; 95% CI 0.5 to 1.58; p<0.001) of individuals after stroke. Regarding the descriptive results, Pilates proved to be effective in improving lower limb motor function, cardiopulmonary function, step length, and gait ability. Conclusion: This systematic review showed, through meta-analysis, that the Pilates method is effective in improving the mobility and quality of life of post-stroke individuals. In addition, descriptive results were significant for lower limb motor function, cardiopulmonary function, step length, and gait ability. However, these latter results deserve caution, as they were all based on descriptive results from only one clinical trial each.
Pertanian Indonesia harus mengembangkan pertanian organik yang ramah lingkungan
Authors: Anto Yudi , Sucipto Adi
Published: December 2023

Pertanian organik adalah jenis pertanian yang hanya menggunakan bahan-bahan alami dan menghindari bahan kimia sintetis. Pertanian organik adalah metode budi daya tanaman agri bisnis secara alami dengan fokus pada perlindungan lingkungan dan pelestarian sumber daya tanah dan air jangka panjang. Dalam pertanian organik, pupuk buatan yang berasal dari bahan bakar fosil, pestisida, dan makanan hasil rekayasa genetika tidak digunakan.Polikultur lebih menguntungkan dalam ekologi pertanian, dan lebih sering digunakan dalam pertanian organik. Berbagai macam serangga bermanfaat, mikroba tanah, dan spesies ramah lahan pertanian lainnya tertarik pada berbagai macam sayuran. Keanekaragaman tanaman pertanian membantu ekosistem mencegah kepunahan spesies yang hidup di dekat pertanian.Selalu pikirkan bagaimana menggunakan sumber daya secara lebih efisien, bagaimana menggunakan bahan enterik eksternal dengan lebih efisien, bagaimana mengurangi biaya medis, dan bagaimana meningkatkan pendapatan/nilai yang disumbangkan dalam sistem pertanian organik. Permintaan akan barang-barang pertanian organik dan ramah lingkungan meningkat sebagai akibat dari tumbuhnya "tren" gaya hidup sehat di masyarakat global, disertai dengan semboyan "kembali ke alam".
Organização das nações unidas, democracia e políticas públicas para o desenvolvimento humano brasileiro
Authors: Araújo Lima Raquel , Medeiros Nelson Aline Virgínia
Published: December 2023

O quadro contínuo de exclusão social levou a questionamentos sobre como concretizar o desenvolvimento humano, os quais foram fundamentados na controvérsia entre as correntes universalistas e contextualistas. Objetivando aprofundar essa discussão, através de método hermenêutico e uso de técnica bibliográfica, mas também utilizando o empírico, por análise de relatórios, será verificada a atuação da Organização das Nações Unidas para condução da gestão pública no Brasil e a defesa da democracia como ponto de convergência entre a necessidade de declarar direitos e a de realizá-los por produção de políticas efetivas. Assim, constatou-se que a democracia e o ativismo social são os mecanismos essenciais ao planejamento e a realização de políticas pública, pelos Estados, em âmbito intergovernamental.
Business game “High-tech Pediatric Surgery”: Modeling of management decisions in children’s health protection in the Far Eastern Federal District
Authors: Morozov Dmitry A. , Rozinov Vladimir M. , Suvorov Sergey G. , Ampar Fatima B. , Strizhnev Sergey V. , Vaganov Nikolay N.
Published: December 2023

BACKGROUND: The difference in the levels of total infant mortality in certain administrative territorial entities of the country is an acute medical and social problem of domestic healthcare, which indicates the absence of a single standard of accessibility and quality of medical care. This indicator in the Far Eastern Federal District significantly exceeds the corresponding indicators in the Central and Northwestern districts.
AIM: This study aimed to identify unresolved problems and identify ways to improve the availability and quality of surgical care for children by modeling the process of making administrative and clinical decisions by employees of medical organizations and heads of healthcare in the Far Eastern Federal District in the interests of children in need of specialized, including high-tech, medical care, including medical evacuation.
MATERIALS AND METHODS: A “business game” with simultaneous implementation of the simulation process in 11 regions of the Far Eastern Federal District was conducted using distributed communication channels and technical capabilities of audiovisual fixation of the opinions of the study participants. A series of five business games on the following profiles were implemented: neonatal surgery, thoracic surgery, neurosurgery, oncology, and combustiology. The scenarios of the games were prepared by the organizers of the study: “Russian Association of Pediatric Surgeons” (LLC) and “Agency for Strategic Initiatives to promote new projects” (ANO). The moderators of the games were leading specialists from specialized federal medical organizations. The game participants were regional teams of the subjects of the Far Eastern Federal District. The observers of the games were representatives of federal legislative and executive authorities and healthcare experts.
RESULTS: In this study, 9–11 regions of the Far Eastern Federal District participated in a series of five games. The total number of participants in business games ranged from 126 to 151, and the number of connection points was 42–66. The identified problematic issues included organizational (9), personnel (8), transport (7), equipment (7), and financial (6) aspects.
CONCLUSIONS: The ideology of the interregional centers of specialized surgical care for children corresponds to the vision of representatives of the professional community and organizers of territorial healthcare as a promising way to increase the availability and quality of medical care to the pediatric population.
Craniofacial wound from a traumatic pistol injury in a 3-year-old child
Authors: Petlakh Vladimir I. , Gorchakov Sergei A. , Divilina Yulia V.
Published: December 2023

With the advent of traumatic self-defense weapons among Russian civilians (weapons of limited destruction and nonlethal kinetic weapons), several studies on injuries among the adult population have been published in the medical literature. Skull injuries are the most severe, often fatal, injuries. To date, there are only isolated descriptions of such injuries in children.
Description of the observation. According to the parents, the 3-year-old boy shot himself in the face with an Osa-4 pistol at home. He did not lose consciousness, and the bleeding was light. He was admitted to the central district hospital, from where he was evacuated by an ambulance team to Children’s City Clinical Hospital No. 9 named after. G.N. Speransky, Moscow. Upon admission, the patient was in a serious condition, conscious, and lethargic, reacted negatively to examination, and had 14 points on the Glasgow coma scale, and his hemodynamics was stable. Local status: In the upper part of the dorsum of the nose, a bullet entry hole was observed in the form of a bruised wound of irregular shape, pronounced swelling in the area of the left orbit, and hematoma of the upper eyelid. X-ray images of the skull showed a shadow of a foreign body (bullet) in the projection of the left orbit and ethmoidal labyrinth. The location and extent of damage were clarified by computed tomography. Under endotracheal anesthesia, a supraorbital trans-eyebrow approach on the left with layer-by-layer tissue dissection along the wound canal exposed a part of the bullet, wedged into the medial wall of the orbit and cells of the ethmoid bone. The bullet was removed, and bone fragments and layer-by-layer sutures were removed. Diagnosis: Gunshot causing a blind craniofacial non-penetrating wound in the dorsum of the nose and left orbit, multiple comminuted fractures of the ethmoid bones and superior and medial walls of the left orbit, contusion of the basal parts of the left frontal region of the brain, blunt trauma OS stage 2, local contusion, and retinal hemorrhage The postoperative period passed without complications. The child received a combination of antibacterial and restorative therapy. Vision was preserved, no neurological disorders were detected, and the cosmetic result was good. The patient was discharged in satisfactory condition under the supervision of an ophthalmologist, neurologist, and maxillofacial surgeon. This observation is presented to demonstrate damage to skull structures from traumatic weapons and will aid in further generalization of the treatment results of this type of wound in children. Prevention of injuries in children from traumatic weapons requires extensive educational work among parents who own these weapons.
estranho chá e outros bichos
Authors: Nascimento Naira de Almeida
Published: December 2023

Conotada normalmente com o gênero fantástico, uma parte da contística de Lygia Fagundes Telles pode, contudo, ser relida pela perspectiva dos Estudos Críticos Animais. O recente falecimento da escritora, culminando também em iniciativas como a da Companhia das Letras, que fez a publicação integral de seus contos (2018), enseja a uma retomada de sua obra. A virada animal, ponto de partida das reflexões conduzidas, prima, primeiramente, por questionar a centralidade conferida ao animal humano, em particular na cultura ocidental e sobretudo a partir da modernidade. A era do antropoceno caracteriza-se justamente por esta imposição autoritária das necessidades e dos desejos humanos frente aos direitos advindos de outras formas de vida. A análise do conto “Tigrela”, de Seminário dos ratos (1977), pretende atentar para sentidos além da mera animalização contida na evocação da protagonista e, perceber na escrita de Lygia um jogo entre as figurações de animais não-metafóricas (FERRREIRA, 2005), que se aproxima de algumas realizações de João Guimarães Rosa e de Clarice Lispector. Lidos hoje pelos Estudos Críticos Animais, tanto os textos de Rosa como de Clarice elucidam uma relação possível e até desejada entre animais humanos e não-humanos, a partir de uma conscientização do papel subalterno exercido pelos não-humanos no nosso imaginário. A leitura do texto conta ainda com a fundamentação teórica baseada no conceito de devir (DELEUZE; GUATTARI, 2012) e nas apreensões do antiespecismo feminino, além das considerações críticas de Gabriel Giorgi e de Julieta Yelin.
Formulation and effectiveness test of clove flower oil (Syzygium aromaticum L.) nanoemulsigel preparations against Propionibacterium acnes bacteria
Authors: Sembiring Pintata , Reveny Julia , Dalimunthe Aminah
Published: December 2023

Background: Acne is a chronic inflammatory process in the pilosebaceous glands. The appearance of acne is a process of follicular hyper-keratinization, which causes blockage of the pores so that the hair follicles are blocked by bacteria known as Propionibacterium acnes. Clove flower oil contains eugenol compounds which have the strongest activity against gram-positive and gram-negative bacteria.
Methods: In this research, antibacterial activity tests were carried out on clove flower oil with various concentrations and nano-emulsion gel preparations were made with a clove flower oil concentration of 1.5%; 3%; 5.5%, which was then tested for antibacterial activity on the nano-emulsion gel preparations of clove flower oil measured using a caliper and the diameter of the inhibition zone produced was recorded.
Results: the results of the organoleptic research showed that the color was yellow, transparent and had a distinctive odor, homogeneity showed that there were no coarse particles, viscosity was still within the required range, pH showed that the pH was still within the required range of 4.5-6.5, particle size test was below 200 nm, cycling test showed that it was stable during storage at hot and cold temperatures for 6 cycles of P. acnes inhibitory clove flower oil nano-emulsion preparation with a concentration of 1.5%; 3%; 5.% respectively have resistance of 11.60 mm, 13.53 mm, 15.76 mm
Conclusions: From the results of the research that has been carried out, it is concluded that clove flower oil can be formulated into a nano-emulsion gel preparation, is stable during cycling tests, and has a particle size below 200 nm. Nano-emulsion gel formulations have the greatest antibacterial activity compared to emulsion gel formulations.
Localised sinonasal amyloidosis presenting with unilateral hearing loss: a case report and review of the literature
Authors: Suseeharan Melanie , Dusu Keli , Motter Dema , Balfour Alistair
Published: December 2023

Localised sinonasal amyloidosis is a rare occurrence with only twenty-nine documented cases in literature. This report follows the case of a 79-year-old gentleman with an atypical presentation of headaches and unilateral (right-sided) hearing loss. The patient initially underwent magnetic resonance imaging of his internal auditory meatus which was normal. Flexible nasoendoscopy was performed which identified a right middle meatus discharging possible polypoidal lesion. A computed tomography scan of his sinuses was performed which identified a large soft tissue lesion projecting into the upper nasal airway arising from the nasal recess, with the appearance suspicious for a polyp. Subsequently, the patient underwent functional endoscopic sinus surgery to manage right maxillary sinusitis and further examine the right-sided polypoidal mass lesion that was obstructing the maxillary antrum. Maxillary sinus biopsy revealed a diagnosis of sinonasal amyloidosis while tests for systemic amyloidosis were negative.