bluuebunny/crossref_metadata_2025 huggingface dataset:
The use of mental maps in the assessment of geographic knowledge: Form and content of map sketches drawn by last year Primary Education students in the Balearic Islands (Spain)
Authors: Binimelis Sebastián Jaume , Pla-Sanchís Carla , Serrano-Varón Julián , Sánchez Casado Marta
Published: July 2023

This work pursues the study of mental maps as a tool to assess the geographic knowledge of the Balearic Islands among school students from 17 primary education schools. The study reveals an interrelationship between the formal aspects of the cartographic sketches and the level of geographic knowledge expressed (content) through the mentioned places. This finding adds value to the power of cartographic sketching as a tool for the study of geographic knowledge, disproving those who question it.
The Impact of the Outbreak of Russia-Ukraine War on Commodity, Stock and Cryptocurrency Markets
Authors:   Faculty of Management, University of Warsaw, Karasińki Jacek , Zadrożny Jan ,   Faculty of Management, University of Warsaw
Published: July 2023

Purpose: This paper analyzes the impact of the Russian invasion of Ukraine in February 2022 on returns of three groups of assets, i.e., commodities, stocks, and cryptocurrencies. Methodology: The study was conducted using the event study method which allows for quantifying the reaction of market participants to releases of various types of information. Findings: The cumulative abnormal returns (CARs) suggest a mostly positive effect of the conflict outbreak on returns of several commodities, especially precious metals. The obtained results suggest that in times of global crises, investors may consider precious metals as a safe haven. The study also indicates that on the event day the examined stock markets reacted negatively to information about the war, but to varying degrees. The Russian aggression against Ukraine did not affect the cryptocurrency markets in a statistically significant manner. Research limitations: The future studies related to the issue of the impact of Russian aggression against Ukraine on different markets may utilize larger research samples. They also may look for some factors affecting the reaction of markets to information related to the Russian military aggression, like the size of markets, trading volume, or geographical proximity, and economic dependence in the case of equity markets. Value: The study may provide some practical implications for both investors and regulators, especially in relation to the expected behavior of the markets and their informational efficiency in times of global crisis.
Las empresas de inserción como aliadas para llevar a cabo una transición ecológica, en particular en la economía circular y en los empleos verdes
Authors: Álvarez Cuesta Henar
Published: July 2023

Frente al cambio climático resulta imprescindible reforzar analizar las posibilidades que presentan las entidades de economía social para llevar a cabo la transición ecológica. En particular, se analiza el papel de las empresas de inserción en la lucha contra la vulnerabilidad social y la protección medioambiental, desde su regulación laboral, incluyendo la cualificación y recualificación en empleos verdes para el personal en inserción, hasta las posibilidades de convertirse en un laboratorio para la creación de empleos verdes y para formar parte de la economía circular a través de la gestión de residuos y reciclaje. Finalmente, se destaca la importancia del impulso a la alianza entre empresas de inserción y la lucha contra el cambio climático desde las administraciones públicas
Reducing Underachievement and Promoting Critical Thinking Skills in Computer Studies Through a Culturally Sensitive Instructional Method
Authors: Gbeleyi Olasunkanmi Adio , Olusegun Oguntade Paul , Tetteh Andrew
Published: July 2023

This study aims to determine the effectiveness of the Culturo-Techno-Contextual Ap- proach (CTCA) on students’ achievement and critical thinking skills in Computer Studies. The study was conducted in two phases. Phase one was a survey of difficult concepts in computer science/studies. While phase two explored the potency of the Culturo-Techno-Contextual Approach (CTCA) in breaking the barriers to meaningful learning of refractive indices. Results obtained from the survey in the first phase revealed 19 topics as a difficult topic among African secondary school students in computer studies. The second phase was guided by two research questions with two public junior secondary (JS) in Lagos State (Nigeria). About 38% of the respondents were males while about 62% were females. A critical thinking skills task (CTST), and an interview guide were used to collect data for the study. The data gathered was subjected to multivariate analysis of covariate (MANCOVA), and the results revealed a statistically significant difference in the methods used, multivariate F (Pillai’s Trace) was significant [F=17.67; p<.05], univariate ANOVA on achievement [F (2, 208) = 20.67; p<0.05]; and critical thinking skills [F (2, 208) = 15.14; p<0.05]. Within the scope of the study, it was tentatively recommended that CTCA should be adopted by computer studies teachers in the teaching of computer science/studies in secondary schools.
Exploring the Positive Experiences of Senior High School Teachers in Teaching the Sports Track during the K-12 Transition Years in Southern Philippines
Authors: Poblador Steffany Anne , Lagunero-Tagare Ruben Jr
Published: July 2023

Implementing the Enhanced Basic Education Act (GOVPH, 2013), has significantly transitioned the Philippine Education System. While research in Physical Education has explored the early impact of this educational reform since its enactment in 2013,  there is a noticeable absence of studies focusing on teachers’ favorable experiences in teaching the Sports Track Program in Se- nior High School. To address this research gap, a Qualitative Phenomenology Research Design was employed to investigate and elicit the favorable stories and experiences of teachers engaged in this program. Participants from selected schools in the Cotabato Province (Philippines),  participated   in focus groups, in-depth interviews, and extensive field observations, ensuring data triangulation. Five significant issues emerged from the participants’ narratives through this rigorous approach. These issues encompass participative and kinesthetically intelligent learners, alignment between Sports Track competencies and teachers’ college-acquired knowledge, promoting interactive teaching and learning practices, incorporating practical and hands-on activities within the curriculum, and facilitating more straightforward curriculum implementation. The findings of this study contribute to the development of conclusions and implications for enhancing the performance of the Sports Track Program within the Philippine Senior High School Curriculum. By understanding  the favorable experiences of teachers,  this research serves as a valuable resource to inform policy improvements and pedagogical practices that can further optimize the Sports Track Program’s effectiveness and overall educational outcomes.
The Influence of Bilateral and Unilateral Flatfoot on Coronal Spinopelvic Alignment in Asymptomatic Young Healthy Males
Authors: Kisacik Pinar , Ceyhan Erman
Published: July 2023

Background: This cross-sectional retrospective study aimed to present the influence of unilateral and bilateral flatfoot on coronal spinopelvic alignment in asymptomatic young healthy males.

Methods: This study was performed by examining the medical reports of individuals who applied to the National Health Board to work in positions requiring physical fitness between January 1, 2018, and January 1, 2019. Plain radiographs of the feet, pelvis, and spine were analyzed. The calcaneal pitch angle for flatfoot, pelvic obliquity, and the Cobb angle for spinal asymmetry were measured. After all of the analyses were completed, participants were divided into two groups—unilateral or bilateral flatfoot, depending on the calcaneal pitch angle measurements—and compared.

Results: There was no significant difference in age between groups (P = .609). The unilateral flatfoot group showed higher values in terms of body mass index, with a significant difference (P = .01). The curve patterns were identified as single thoracic, lumbar, and double. Post-hoc analyses suggest that young males without spinal asymmetry were more likely to have unilateral flatfoot (P < .008). There were significant differences between groups in pelvic obliquity and Cobb angle (P < .05). The effect size was found to be small to medium for pelvic obliquity and medium to large for Cobb angle.

Conclusions: Young males with bilaterally increased foot pronation demonstrate more increased pelvic obliquity and spinal curvature.
The Human Mitochondrial Genome Encodes for an Interferon-Responsive Host Defense Peptide
Authors: Rice MC , Kim JS , Imun M , Jung SW , Park CY , Lai RW , Barr CR , Son JM , Tor K , Kim E , Lu RJ , Cohen I , Benayoun BA , Lee C
Published: July 2023

The mitochondrial DNA (mtDNA) can trigger immune responses and directly entrap pathogens, but it is not known to encode for active immune factors. The immune system is traditionally thought to be exclusively nuclear-encoded. Here, we report the identification of a mitochondrial-encoded host defense peptide (HDP) that presumably derives from the primordial proto-mitochondrial bacteria. We demonstrate that MOTS-c (mitochondrial open reading frame from the twelve S rRNA type-c) is a mitochondrial-encoded amphipathic and cationic peptide with direct antibacterial and immunomodulatory functions, consistent with the peptide chemistry and functions of known HDPs. MOTS-c targeted
E. coli
and methicillin-resistant
S. aureus
(MRSA), in part, by targeting their membranes using its hydrophobic and cationic domains. In monocytes, IFNγ, LPS, and differentiation signals each induced the expression of endogenous MOTS-c. Notably, MOTS-c translocated to the nucleus to regulate gene expression during monocyte differentiation and programmed them into macrophages with unique transcriptomic signatures related to antigen presentation and IFN signaling. MOTS-c-programmed macrophages exhibited enhanced bacterial clearance and shifted metabolism. Our findings support MOTS-c as a first-in-class mitochondrial-encoded HDP and indicates that our immune system is not only encoded by the nuclear genome, but also by the co-evolved mitochondrial genome.
Searching for molecular hypoxia sensors among oxygen-dependent enzymes
Authors: Li Li , Shen Susan , Bickler Philip , Jacobson Matthew P , Wu Lani F , Altschuler Steven J
Published: July 2023

The ability to sense and respond to changes in cellular oxygen levels is critical for aerobic organisms and requires a molecular oxygen sensor. The prototypical sensor is the oxygen-dependent enzyme PHD: hypoxia inhibits its ability to hydroxylate the transcription factor HIF, causing HIF to accumulate and trigger the classic HIF-dependent hypoxia response. A small handful of other oxygen sensors are known, all of which are oxygen-dependent enzymes. However, hundreds of oxygen-dependent enzymes exist among aerobic organisms, raising the possibility that additional sensors remain to be discovered. This review summarizes known and potential hypoxia sensors among human O2-dependent enzymes and highlights their possible roles in hypoxia-related adaptation and diseases.
Comparative Interactome Analysis of α-arrestin Families in Human and Drosophila
Authors: Lee Kyungtae , Pranoto Inez K.A. , Kim Soon-Young , Choi Hee-Joo , To Ngoc Bao , Chae Hansong , Lee Jeong-Yeon , Kim Jung-Eun , Kwon Young , Nam Jin-Wu
Published: July 2023

The α-arrestins form a large family of evolutionally conserved modulators that control diverse signaling pathways, including both G-protein-coupled receptor (GPCR-) mediated and non-GPCR mediated pathways, across eukaryotes. However, unlike β-arrestins, only a few α-arrestin targets and functions have been characterized. Here, using affinity purification and mass spectrometry, we constructed interactomes for six human and twelve
Drosophila
α arrestins. The resulting high-confidence interactomes comprised 307 and 467 prey proteins in human and
Drosophila
, respectively. A comparative analysis of these interactomes predicted not only conserved binding partners, such as motor proteins, proteases, ubiquitin ligases, RNA splicing factors, and GTPase-activating proteins, but also those specific to mammals, such as histone modifiers and the subunits of V-type ATPase. Given the manifestation of the interaction between the human α-arrestin, TXNIP, and the histone-modifying enzymes, including HDAC2, we undertook a global analysis of transcription signals and chromatin structures that were affected by TXNIP knockdown. We found that TXNIP activated targets by blocking HDAC2 recruitment to targets, a result that was validated by chromatin immunoprecipitation assays. Additionally, the interactome for an uncharacterized human α- arrestin ARRDC5 uncovered multiple components in the V-type ATPase, which plays a key role in bone resorption by osteoclasts. Our study presents conserved and species-specific protein-protein interaction maps for α-arrestins, which provide a valuable resource for interrogating their cellular functions for both basic and clinical research.
Tools and methods for high-throughput single-cell imaging with the mother machine
Authors: Thiermann Ryan , Sandler Michael , Ahir Gursharan , Sauls John T. , Schroeder Jeremy W. , Brown Steven D. , Le Treut Guillaume , Si Fangwei , Li Dongyang , Wang Jue D. , Jun Suckjoon
Published: July 2023

Despite much progress, image processing remains a significant bottleneck for high-throughput analysis of microscopy data. One popular platform for single-cell time-lapse imaging is the mother machine, which enables long-term tracking of microbial cells under precisely controlled growth conditions. While several mother machine image analysis pipelines have been developed in the past several years, adoption by a non-expert audience remains a challenge. To fill this gap, we implemented our own software, MM3, as a plugin for the multidimensional image viewer napari. napari-MM3 is a complete and modular image analysis pipeline for mother machine data, which takes advantage of the high-level interactivity of napari. Here, we give an overview of napari-MM3 and test it against several well-designed and widely-used image analysis pipelines, including BACMMAN and DeLTA. In addition, the rapid adoption and widespread popularity of deep-learning methods by the scientific community raises an important question: to what extent can users trust the results generated by such “black box” methods? We explicitly demonstrate “What You Put Is What You Get” (WYPIWYG); i.e., the image analysis results can reflect the user bias encoded in the training dataset. Finally, while the primary purpose of this work is to introduce the image analysis software that we have developed over a decade in our lab, we also provide useful information for those who want to implement mother-machine-based high-throughput imaging and image analysis methods in their research. This includes our guiding principles and best practices to ensure transparency and reproducible results.
Ulk4 promotes Shh signaling by regulating Stk36 ciliary localization and Gli2 phosphorylation
Authors: Zhou Mengmeng , Han Yuhong , Jiang Jin
Published: July 2023

The Hedgehog (Hh) family of secreted proteins governs embryonic development and adult tissue homeostasis through the Gli family of transcription factors. Gli is thought to be activated at the tip of primary cilium, but the underlying mechanism has remained poorly understood. Here, we show that Unc-51-like kinase 4 (Ulk4), a pseudokinase and a member of the Ulk kinase family, acts in conjunction with another Ulk family member Stk36 to promote Gli2 phosphorylation and Hh pathway activation. Ulk4 interacts with Stk36 through its N-terminal region containing the pseudokinase domain and with Gli2 via its regulatory domain to bridge the kinase and substrate. Although dispensable for Hh-induced Stk36 kinase activation, Ulk4 is essential for Stk36 ciliary tip localization, Gli2 phosphorylation, and activation. In response to Hh, both Ulk4 and Stk36 colocalize with Gli2 at ciliary tip, and Ulk4 and Stk36 depend on each other for their ciliary tip accumulation. We further show that ciliary localization of Ulk4 depends on Stk36 kinase activity and phosphorylation of Ulk4 on Thr1023, and that ciliary tip accumulation of Ulk4 is essential for its function in the Hh pathway. Taken together, our results suggest that Ulk4 regulates Hh signaling by promoting Stk36-mediated Gli2 phosphorylation and activation at ciliary tip.
Characterization of tryptophan oxidation affecting D1 degradation by FtsH in the photosystem II quality control of chloroplasts
Authors: Kato Yusuke , Kuroda Hiroshi , Ozawa Shin-Ichiro , Saito Keisuke , Dogra Vivek , Scholz Martin , Zhang Guoxian , de Vitry Catherine , Ishikita Hiroshi , Kim Chanhong , Hippler Michael , Takahashi Yuichiro , Sakamoto Wataru
Published: July 2023

Photosynthesis is one of the most important reactions for sustaining our environment. Photosystem II (PSII) is the initial site of photosynthetic electron transfer by water oxidation. Light in excess, however, causes the simultaneous production of reactive oxygen species (ROS), leading to photo-oxidative damage in PSII. To maintain photosynthetic activity, the PSII reaction center protein D1, which is the primary target of unavoidable photo-oxidative damage, is efficiently degraded by FtsH protease. In PSII subunits, photo-oxidative modifications of several amino acids such as Trp have been indeed documented, whereas the linkage between such modifications and D1 degradation remains elusive. Here, we show that an oxidative post-translational modification of Trp residue at the N-terminal tail of D1 is correlated with D1 degradation by FtsH during high-light stress. We revealed that Arabidopsis mutant lacking FtsH2 had increased levels of oxidative Trp residues in D1, among which an N-terminal Trp-14 was distinctively localized in the stromal side. Further characterization of Trp-14 using chloroplast transformation in Chlamydomonas indicated that substitution of D1 Trp-14 to Phe, mimicking Trp oxidation enhanced FtsH-mediated D1 degradation under high light, although the substitution did not affect protein stability and PSII activity. Molecular dynamics simulation of PSII implies that both Trp-14 oxidation and Phe substitution cause fluctuation of D1 N-terminal tail. Furthermore, Trp-14 to Phe modification appeared to have an additive effect in the interaction between FtsH and PSII core in vivo. Together, our results suggest that the Trp oxidation at its N-terminus of D1 may be one of the key oxidations in the PSII repair, leading to processive degradation by FtsH.
Human-specific lncRNAs contributed critically to human evolution by distinctly regulating gene expression
Authors: Lin Jie , Wen Yujian , Tang Ji , Zhang Xuecong , Zhang Huanlin , Zhu Hao
Published: July 2023

What genomic sequences make conserved genes generate divergent expression in closely related species, which may have critically driven human evolution, has puzzled researchers for decades. Genomic studies have examined species-specific gene birth, gene loss, and changes in promoters and transcription factor binding sites, but species-specific epigenetic regulation remains barely explored. This study identified human-specific long noncoding RNAs (lncRNAs) from GENCODE-annotated human lncRNAs, predicted their DNA binding sites (DBSs) genome-wide, analyzed these DBSs and their counterparts in modern humans (CEU, CHB, and YRI), archaic humans (Altai Neanderthals, Denisovans, and Vindija Neanderthals), and chimpanzees, and analyzed the impact of DBSs on gene expression in modern and archaic humans. The results suggest that human-specific lncRNAs and their DBSs have substantially rewired gene expression human-specifically and that the rewiring has evolved continuously from archaic to modern humans. Rewired gene expression promotes brain development, makes humans adapt to new environments and lifestyles, and causes differences in modern humans. These results uncover a critical dimension of human evolution and underscore the diverse functions of species-specific lncRNAs.
Human-specific lncRNAs contributed critically to human evolution by distinctly regulating gene expression
Authors: Lin Jie , Wen Yujian , Tang Ji , Zhang Xuecong , Zhang Huanlin , Zhu Hao
Published: July 2023

What genomic sequences make protein-coding genes generate divergent expression in closely related species, specifically, differentiate humans from apes, puzzle many researchers. Many studies examined species-specific gene birth, gene loss, and changes in promoters and transcription factor binding sites, but the identification and impact of human-specific lncRNAs remain unexplored. This study identified human-specific lncRNAs from GENCODE-annotated human lncRNAs, predicted their DNA binding sites (DBSs) genome-wide, and analyzed the DBSs and their counterparts in modern humans (CEU, CHB, and YRI), archaic humans (Altai Neanderthals, Denisovans, and Vindija Neanderthals), and chimpanzees. The results reveal how human-specific lncRNAs and their DBSs have transcriptionally regulated gene expression human-specifically. The rewiring of gene expression has undergone continuous evolution, significantly changed gene expression in the brain, promoted the adaptive evolution of humans, and influenced differences in modern humans. These results reveal the importance of human-specific lncRNAs (for human evolution) and highlight the importance of other species-specific lncRNAs.
Dynamic allosteric networks drive adenosine A1 receptor activation and G-protein coupling
Authors: Maria-Solano Miguel A. , Choi Sun
Published: July 2023

G-protein coupled receptors (GPCRs) present specific activation pathways and signaling among receptor subtypes. Hence, an extensive knowledge of the structural dynamics of the receptor is critical for the development of therapeutics. Here, we target the adenosine A
1
receptor (A
1
R), for which a negligible number of drugs have been approved. We combine molecular dynamics simulations, enhanced sampling techniques, network theory and pocket detection to decipher the activation pathway of A
1
R, decode the allosteric networks and identify transient pockets. The A
1
R activation pathway reveal hidden intermediate and pre-active states together with the inactive and fully-active states observed experimentally. The protein energy networks computed throughout these conformational states successfully unravel the extra and intracellular allosteric centers and the communication pathways that couples them. We observe that the allosteric networks are dynamic, being increased along activation and fine-tuned in presence of the trimeric G-proteins. Overlap of transient pockets and energy networks uncover how the allosteric coupling between pockets and distinct functional regions of the receptor is altered along activation. By an in-depth analysis of the bridge between activation pathway, energy networks and transient pockets, we provide a further understanding of A
1
R. This information can be useful to ease the design of allosteric modulators for A
1
R.
An automatic system for extracting figure-caption pair from medical documents: a six-fold approach
Authors: Chaki Jyotismita
Published: July 2023

Background

Figures and captions in medical documentation contain important information. As a result, researchers are becoming more interested in obtaining published medical figures from medical papers and utilizing the captions as a knowledge source.

Methods

This work introduces a unique and successful six-fold methodology for extracting figure-caption pairs. The A-torus wavelet transform is used to retrieve the first edge from the scanned page. Then, using the maximally stable extremal regions connected component feature, text and graphical contents are isolated from the edge document, and multi-layer perceptron is used to successfully detect and retrieve figures and captions from medical records. The figure-caption pair is then extracted using the bounding box approach. The files that contain the figures and captions are saved separately and supplied to the end useras theoutput of any investigation. The proposed approach is evaluated using a self-created database based on the pages collected from five open access books: Sergey Makarov, Gregory Noetscher and Aapo Nummenmaa’s book “Brain and Human Body Modelling 2021”, “Healthcare and Disease Burden in Africa” by Ilha Niohuru, “All-Optical Methods to Study Neuronal Function” by Eirini Papagiakoumou, “RNA, the Epicenter of Genetic Information” by John Mattick and Paulo Amaral and “Illustrated Manual of Pediatric Dermatology” by Susan Bayliss Mallory, Alanna Bree and Peggy Chern.

Results

Experiments and findings comparing the new method to earlier systems reveal a significant increase in efficiency, demonstrating the suggested technique’s robustness and efficiency.
DNAJ heat shock protein family member C1 can regulate proliferation and migration in hepatocellular carcinoma
Authors: Fan Yu-Chun , Meng Zhi-Yong , Zhang Chao-Sheng , Wei De-Wei , Wei Wan-Shuo , Xie Xian-Dong , Huang Ming-Lu , Jiang Li-He
Published: July 2023

Background

DNAJ heat shock protein family (Hsp40) member C1(DNAJC1) is a member of the DNAJ family. Some members of the DNAJ gene family had oncogenic properties in many cancers. However, the role of DNAJC1 in hepatocellular carcinoma (HCC) was unclear.

Methods

In this study, expression and prognostic value of DNAJC1 in HCC were analyzed by bioinformatics. Quantitative real-time PCR and Western blotting were used to verify DNAJC1 expression in liver cancer cell lines. Furthermore, immunohistochemical (IHC) was used to detect DNAJC1 expression in liver cancer tissues. Subsequently, the effect of DNAJC1 on the proliferation, migration, invasion and apoptosis of HCC cells was detected by knocking down DNAJC1. Finally, gene set enrichment analysis (GSEA) was used to investigate the potential mechanism of DNAJC1 and was verified by Western blotting.

Results

DNAJC1 was highly expressed in HCC and was significantly associated with the prognosis of patients with HCC. Importantly, the proliferation, migration and invasion of Huh7 and MHCC97H cells were inhibited by the knockdown of DNAJC1 and the knockdown of DNAJC1 promoted Huh7 and MHCC97H cell apoptosis. Furthermore, compared to the negative control group, DNAJC1 knockdown in Huh7 and MHCC97H cells promoted the expression of p21, p53, p-p53(Ser20), Bax and E-cadherin proteins, while inhibiting the expression of PARP, MMP9, Vimentin, Snai1, Bcl-2 and N-cadherin proteins.

Conclusions

DNAJC1 had a predictive value for the prognosis of HCC. Knockdown of DNAJC1 may inhibit HCC cell proliferation, migration and invasion and promote the HCC cell apoptosis through p53 and EMT signaling pathways.
Environmental factors affecting honey bees (Apis cerana) and cabbage white butterflies (Pieris rapae) at urban farmlands
Authors: Lee Myung-Bok
Published: July 2023

Rapid urbanization results in a significantly increased urban population, but also the loss of agricultural lands, thus raising a concern for food security. Urban agriculture has received increasing attention as a way of improving food access in urban areas and local farmers’ livelihoods. Although vegetable-dominant small urban farmlands are relatively common in China, little is known about environmental factors associated with insects that could affect ecosystem services at these urban farmlands, which in turn influences agricultural productivity. Using Asian honey bee (Apis cerana) and cabbage white butterfly (Pieris rapae) as examples, I investigated how environmental features within and surrounding urban farmlands affected insect pollinator (bee) and pest (butterfly) abundance in a megacity of China during winters. I considered environmental features at three spatial scales: fine (5 m-radius area), local (50 m-radius area), and landscape (500 m-raidus and 1 km-radius areas). While the abundance ofP. rapaeincreased with local crop diversity, it was strongly negatively associated with landscape-scale crop and weed covers.A. ceranaresponded positively to flower cover at the fine scale. Their abundance also increased with local-scale weed cover but decreased with increasing landscape-scale weed cover. The abundance ofA. ceranatended to decrease with increasing patch density of farmlands within a landscape, i.e., farmland fragmentation. These results suggest that cultivating too diverse crops at urban farmlands can increase crop damage; however, the damage may be alleviated at farmlands embedded in a landscape with more crop cover. Retaining a small amount of un-harvested flowering crops and weedy vegetation within a farmland, especially less fragmented farmland can benefitA. ceranawhen natural resources are scarce.
O poder judiciário e o adicional de um terço para servidores públicos com previsão legal de mais de trinta dias de férias, à luz da gestão de conflitos
Authors: Serafim Paula Maria Resende Vieira , Perez Filho Augusto Martinez
Published: July 2023

A judicialização de conflitos públicos estaduais é ainda muito expressiva no Brasil. O Estado de Minas Gerais não conta com uma efetiva política de gestão de riscos e controles internos, principalmente para constatar problemas gerenciais e de integridade em seus processos de trabalho, o que facilita a deflagração da judicialização de conflitos.  O tema desenvolvido ganhou repercussão em virtude do surgimento de inúmeras ações judiciais propostas por servidores públicos ocupantes de cargos de magistério no Estado de Minas Gerais. A discussão gira em torno de haver previsão legal de mais de trinta dias de férias durante o ano para esses servidores e a influência desse fato na aplicação do adicional de um terço previsto na Constituição Federal. O Estado de Minas Gerais entende incidir o adicional de um terço sobre apenas trinta dias de férias. O presente trabalho se propõe a responder à pergunta: os professores públicos deveriam receber o adicional constitucional de férias sobre sessenta dias? Para tanto, será utilizado o método dedutivo de pesquisa qualitativa, do tipo teórica. Haverá estudo de jurisprudência, doutrina e artigos acadêmicos envolvendo o tema, bem como das normas vigentes. Ao final, almeja-se demonstrar que por meio de uma interpretação fidedigna à norma jurídica, o direito pleiteado pelos professores públicos destoa da razão da lei e das previsões para os trabalhadores regidos pela CLT, enquadrando mais na definição de privilégio e não de prerrogativa.
Desenvolvimento de competências de escritórios de transferência de tecnologia: uma proposta baseada em processos aprendizagem e na gestão por competências no contexto de uma instituição pública
Authors: Cavalcante Fernando Victor , Renault Thiago Borges
Published: July 2023

Este estudo objetiva propor diretrizes para a capacitação dos Escritórios de Transferência de Tecnologia de uma instituição pública, tendo como escopo processos de aprendizagem e a gestão por competências. Trata-se de uma pesquisa sobre o sistema de gestão tecnológica da Fiocruz, que opera por meio de um escritório central e dezenove núcleos de inovação. Para o desenvolvimento desta pesquisa foi adotado o estudo de caso único, com uma abordagem qualitativa, sendo os dados coletados por meio de pesquisa documental, observação e aplicação de entrevistas semiestruturadas junto aos gestores do aludido sistema. Os resultados permitiam evidenciar que, quando inseridos no contexto do sistema, os gestores desenvolveram competências por meio de processos de aprendizagem experiencial e reflexiva, de modo a superar as dificuldades impostas pela atividade de gestão tecnológica. Com base nos achados propõe-se uma capacitação que reconheça os processos de aprendizagem experiencial vivenciados pelos gestores, bem como a utilização de diversas opções de aprendizagem aplicadas à realidade institucional. Como contribuições teóricas do estudo, os achados permitiram corroborar a existência de processos de aprendizagem experiencial e reflexivos para o desenvolvimento de competências e ligação intrínseca entre vivenciar, compreender, refletir e agir no trabalho de profissionais de Escritórios de Transferência de Tecnologia.
Mensuração de custos em projeto público de ensino superior: um estudo de caso fundamentado em pesquisa in situ
Authors: Vieira Edivaldo , Souza Éliton da Silva , De São Pedro Filho Flávio
Published: July 2023

Sistema de informação gerencial, baseia-se em dados mensurados pelos mecanismos informacionais da administração pública, e requer pesquisas nas plataformas de governança, ensejando o seguinte: Como demonstrar aos gestores públicos que a utilização das informações produzidas pelo sistema de custo pode auxiliar no processo de tomada decisão? Para responder, se propõe como objetivo geral estudar a mensuração na gestão de um projeto público em instituição de ensino superior; caracterizando decisões (1), analisar o impacto do sistema de custos nas decisões (2), propondo inovação com base nesta pesquisa (3). Para produção de resultados, adota-se o método de estudo de caso. Os achados caracterizam sistema de custos em instituição de ensino superior como importante ferramenta, nas classificações, avaliações, controle e planejamento, em suporte à decisão na gestão dos recursos; analisou por meio de diagramas explicativos e quadros especificativos ideais para adequação de apuração dos custos com a verificação dos resultados dos bens e serviços à população; trazendo proposta inovadora na tomada de decisão, em face dos custos, ferramenta Bow-Tie foi considerada na indicação da matriz de riscos a tomada de decisão, diagnosticando possíveis causas e consequências, para mitigar no processo de gestão dos recursos. Contribuindo com gestores, estudiosos e pesquisadores interessados nessa abordagem.
Oral Squamous Cell Carcinoma Metastasising to Unusual Sites: A Case Series of Four Cases
Authors: Agrawal Preeti , Bhamra Swarneet , Singh Rambir , Pandey Ashish , Pandey Megha Shukla
Published: July 2023

Oral cancer ranks as the sixth most common malignancy worldwide, with Squamous Cell Carcinoma (SCC) being the predominant type observed in the head and neck region. Incidence and mortality rates of SCC have significantly increased over the past few decades. Smoking and tobacco chewing are the most common aetiological factors, predominantly affecting elderly males. Distant metastasis at the time of diagnosis is a rare occurrence, typically disseminating through blood vessels or lymphatics. The lungs are the most frequent site for distant metastasis, followed by bone, mediastinal nodes, and occasionally the liver. However, in our cases, we observed metastasis to uncommon sites, excluding the liver. Accurate diagnosis necessitates the correlation with clinical history, radiological, histopathological, and immunohistochemical findings. Despite employing various surgical and radiotherapeutic modalities, distant metastasis diminishes the chances of survival, successful treatment, and worsens the prognosis. This article presents four cases of oral SCC that exhibited metastasis to unusual sites. Two cases had a primary tumour in the left lateral border of the tongue, with distant metastasis to the breast and skin (chest wall), while the other two cases had a primary tumour in the left buccal mucosa and left mandibular region, with distant metastasis to the kidney and liver.
Korean Dramas and Construction of Career Woman Symbols in Post Modern Era
Authors: Herlambang Clara Agnesia , Rewindinar
Published: July 2023

Objectives: This study aimed to explore how the simulacra that occur in binge-watching and uncover symbols constructed in career woman fans of Korean Dramas.

Study Design: The critical constructivist approach was used by applying Baudrillard's Simulacra Theory, which looks at simulations that occur in career women and construct symbols from sign receptions through the media.

Place and Duration of Study: Jakarta, Indonesia, from January – June 2023.

Methodology: This study used critical reflection. The interviews were conducted with ten informants who are careerwomen in Jakarta. The characteristics are having worked for at least three years, having at least one child who is a maximum of 12 years old, and watching Korean dramas for at least 2 hours a day.

Results: As a part of the media, the movie has become a simulation space for individuals. They get experiences that they do not get in their daily lives. Media builds a simulation space that eventually creates a symbol. It occurs in career women who are burdened with their job and managing their families, yet still setting time aside to watch Korean dramas continuously. Career women derive meaning from movies based on the emptiness and lack in their lives. They hope that in real life, they can be such a character in the story. Therefore, Baudrillard stated that individual misreads signs. They cannot distinguish between reality and fantasy. Meanwhile, the media has a magic formula for constructing symbol, in which career women's symbol is constructed through simulation space in binge-watching practice.

Conclusion: Korean Drama has become a simulation space in binge-watching practice by career women. Career women symbol constructed by media is working women with constructed beauty and relation that can raise their social status.
Hepatoprotective and Nephroprotective Effects of Haronga (Harungana madagascariensis) in Combination with Antioxidant Compounds in Albino Spraque Dawley Rats
Authors: Okwulu Oluwadunni Joan , Abatan Matthew Oluwole
Published: July 2023

Aim: The aim of this study was to evaluate the effects of Harungana madagascariensis stem bark ethyl acetate extract with antioxidants on the liver and kidney in rats.

Study Design: Experimental.

Place and Duration of Study: Department of Veterinary Pharmacology and Toxicology, University of Ibadan (from January-February, 2020).

Methodology: This was done using Albino rats (Wistar) grouped into 12 of 5 animals per group for protective studies,ethyl acetate extract (EHM) of the plant at 100mg/kg, 200mg/kg and 500mg/kg in combination with each of Ascorbic acid (200mg/kg), Selenium (1mg/kg) and/or Allopurinol (50mg/kg). Group I-III are control groups, IV-VI EHM/Ascorbic acid, groups VII-IX EHM/Se, and groups X-XII EHM/AL. The combination were administered for 8 days prior acetaminophen (800mg/kg) on day 9. Animals were sacrificed on day 10 and samples were collected for biochemical and histopathological evaluations.

Results: The study showed that acetaminophen induced-stress on the liver and kidney causing increase in liver biomarkers such as the aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphate (ALP), creatinine, blood urea, total protein and gamma-glutamyl transferase (GGT). The combination of H. madagasacariensis Ethyl acetate extract with Ascorbic acid, Allopurinol and/or Selenium at different doses causes protective effects by reducing the release of biomarkers and stabilized the elevated enzymes level shown in acetaminophen group. The histopathology of the liver in the acetaminophen group showed moderate portal congestion with mild periportal cellular infiltration and a moderate to severe portal fibrosis, while the kidney showed severe diffuse tubular degeneration and necrosis.

Conclusion: The EHM (500 mg/kg and 200 mg/kg) in combination with Ascorbic acid, Allopurinol or Selenium protected the liver and kidney from injury induced by Acetaminophen. The Ethyl acetate extract (EHM) of the plant showed synergy with Ascorbic acid, Selenium and Allopurinol to prevent injury on both organs.
Tuberisation Pattern of Tannia (Xanthosoma sagittifolium (L.) Schott) in Response to Crop Management Practices in the South Central Laterites (AEU 9) of Kerala, India
Authors: Sreena K. S. , Shalini Pillai P. , Rajasree G.
Published: July 2023

The study was conducted to outline the rooting and tuberisation pattern of tannia (Xanthosoma sagittifolium (L.) Schott) as influenced by different crop management practices. As an underutilised crop, it was uncertain as to the management techniques which would increase tuberisation and productivity levels of tannia. Hence the study was to promote tuberisation in tannia with a focus on the underground portions of the plant. The variation in rooting pattern was studied in terms of root number, root weight and root volume and the tuberisation pattern as number of cormels per plant, corm weight per plant, cormel weight per plant and rate of tuber bulking. The study was conducted in Kollam district under AEU (Agro Ecological Unit) 9 during the period from Feb 2021- Dec 2021. The experiment comprised three treatments in completely randomised design with six replications. The treatments were t1 - KAU POP (Kerala Agricultural University Package of Practices Recommendations), t2 - farmers’ practice and t3 - absolute control. The results revealed that, the root number (43.29), root weight (32.74 g plant-1) and the root volume (38.22 g plant-1) were significantly the highest in t1 (KAU POP) at harvest followed by farmers’ practice and absolute control. When considering the percentage increase in root production, KAU POP recorded 19.22 per cent, 8.79 per cent, 11.04 per cent and 15.66 per cent more number of roots at 4 MAP, 6 MAP, 8 MAP and harvest than farmers’ practice. The number of cormels per plant (12.16), corm weight per plant (563.16 g), cormel weight per plant (439.16 g) at harvest and the rate of tuber bulking (1.27 kg ha-1 d-1) at 4 to 5 MAP were found to be the highest with t1 followed by t2 and t3.
Efficacy of Selected Insecticides with Botanicals and Bio-agents against Diamondback Moth, Plutella xylostella (L.) in Cabbage, Brassica oleracea var capitata (L.)
Authors: Jyoshna Mukala , Yadav Usha
Published: July 2023

Field trial was conducted during rabi season 2022-2023 at Central Research Farm (CRF) , SHUATS. The experiment was laid out in Randomised block design with eight treatments each replicated thrice using a variety Green Soccer (546). The treatments are T1 Chlorantraniliprole 18.5 % SC, T2 Indoxacarb 14.5% SC, T3 Flubendiamide 39.3 SC, T4 Bacillus thuringeninsis (1x108 CFU/ml), T5 Metarhizium anisiopilae (1x108 CFU/ml), T6 NSKE 5%, T7 Spinosad 45% SC and along with an untreated T8 control against Plutella xylostella in Cabbage. Mean reduction in the larval population of Diamond back moth per plant revealed that all treatments significantly superior over control (4.200). Among all the treatments T1 Chlorantraniliprole 18.5 % SC recorded highest larval reduction with mean (1.000) of Plutella Xylostella followed by T2 Indoxacarb 14.5% SC (1.178), T7 Spinosad 45% SC (1.311), T3 Flubendiamide 39.3 SC (1.322), T5 Metarhizium anisiopilae (1x108 CFU/ml) (1.456), T4 Bacillus thuringeninsis (1x108 CFU/ml) (1.522) and T6 NSKE 5% (1.734) and least recorded in T8 control (4.200). Highest yield 336 q/ha as well as B:C ratio (1:5.35) was obtained from the treatment Chlorantraniliprole 18.5% SC followed by T2 Indoxacarb 14.5% SC (1:5.28), T7 Spinosad 45% SC (1:4.85) T3 Flubendiamide 39.3 SC (1:4.83), T5 Metarhizium anisiopilae (1x108 CFU/ml) (1:4.18), T4 Bacillus thuringeninsis (1x108 CFU/ml) (1:4.71) and T6 NSKE 5% (1:3.52) superior over the control (1:2.87).
Effect of Shoot Bending at Different Time on Production and Quality of Hybrid Tea Rose Cultivar Minu Pearle
Authors: Atal Heera Lal , Mitra Madhumita
Published: July 2023

A field experiment was undertaken from September to March for two consecutive years (2020 and 2021) to find out the best time for shoot bending in Hybrid Tea rose. Growth and development of rose cultivar Minu Pearle, was significantly influenced by shoot bending at different time (4th week of September to 4th week of December). Among the treatments tallest plants & maximum leaf area was produced in plants bended on T5 whereas, the plant canopy was registered to be maximum in 2nd week of December. The highest rate of shoot elongation at 15 & 30 days after shoot bending was noted in second week of November and October respectively. Application of shoot bending on 2nd week of October recorded early blooming and slowest flower bud emergence was registered in T5whereas, delayed sepal reflex and maximum days taken to attain cup shape was observed in T6. In terms of flower quality parameters like length and diameter of flower bud and pedicel and weight of individual flower, T5 proved to be superior. Shoot bending applied on 2nd week of November (T4) produced long and thick stalks. Among the treatments maximum number of flowers, longest self and vase life, highest dry matter production from leaves and stem, greater chlorophyll and anthocyanin content was observed in T5.
Response of Sulphur and Zinc on Yield and Economics of Pearl Millet (Pennisetum glaucum L.)
Authors: Bhargavi K. , Singh Rajesh , Indu Thakur
Published: July 2023

The present study aimed to highlights the response of Sulphur and Zinc on Yield and Economics of Pearl Millet. (Pennisetum glaucum L.). Pearl milet and lentil (Lens culinaris Medikus) are very important crops in the Agra region of Uttar Pradesh for their contribution to human and animal nutrition as components of cropping system and as restorers of soil fertility. A field experiment was conducted during Zaid season of 2022 at the Crop Research Farm, Department of Agronomy, Naini Agricultural Institute, Sam Higginbottom University of Agriculture, Technology and Sciences, Prayagraj (U.P.) India. The treatments consist of Sulphur 20,30,40 kg/ha and zinc 5, 10, 15 kg/ha. The soil of experimental plot was sandy loamy in texture, nearly neutral in soil reaction (pH 7.8), low in organic carbon (0.35%) available N (163.42 kg/ha), available P (21.96 kg/ha) and available K (256.48 kg/ha). Results revealed, that the higher grain yield (40.95 q/ha) and higher stover yield (40.95 q/ha) were significantly influenced with application of Sulphur 40 kg/ha +Zinc 15 kg/ha. Higher gross returns (INR 92145.00/ha), higher net returns (INR 62365.00/ha) and higher B:C ratio (2.09) were also recorded in treatment-9 (Sulphur 40 kg/ha +Zinc 15 kg/ha). The findings are based on one season therefore; further trials may be required for further confirmation.
Restrained dr-Power Dominating Sets in Graphs
Authors: Cabahug Isagani S. , Eballe Rolito G. , Balingit Cherry Mae R.
Published: July 2023

Consider a nontrivial connected graph G. In this context, a set R that is not empty and a subset of V (G) is referred to as a restrained dr-power dominating set of G. This means that the induced subgraph of the complement of R in G does not contain any isolated vertex and qualifies as a dr-power dominating set of G. To determine the restrained dr-power domination number of G, denoted as y*rpw (G), we look at the minimum cardinality of a restrained dr-power dominating set. This study presents significant insights into the restrained dr-power dominating set of a graph G. It provides concrete realizations and exact values for the restrained dr-power domination number within specific graph classes, such as path and cycle graphs, as well as in the context of join and corona operations. Additionally, characterizations of the restrained dr-power dominating set in the join and corona of graphs are demonstrated.