bluuebunny/crossref_metadata_2025 huggingface dataset:
IMPLEMENTASI PROBLEM BASED LEARNING MENGGUNAKAN MEDIA GAMBAR UNTUK MENINGKATKAN KESADARAN SOSIAL SISWA KELAS XI IPS 1 SMA NEGERI 1 ALALAK
Authors: Isyra Agus Suwarni
Published: March 2020

Applying social awareness to others in everyday life can be interpreted as humans social beings. People who care with each other, interact with each other, respect for others in terms of differences of opinion, ethnicity, race, language and religion. In the context of learning required a strategy planned by teachers by promoting activity or creativity of learners in learning activities in order to shape the character of social awareness by learning model Problem Based Learning (PBL) using pictures as a medium.This type of research is used in a classroom action research (PTK). The study design refers to the model Kemmis & Mc. Taggart system uses a spiral of self-reflection that starts from the plan (plan), action (act), observation (Observe), reflection (Reflect), and re-planning is the basis for troubleshooting steps.The results show if the activity of the teacher in the learning process of 75% to 93.75%, Activities of students from 77.5% to 80.55%, and the provision of learning outcomes from 63.34% to 100%. Application of Problem Based Learning using media images can raise awareness of social class XI IPS in SMA Negeri 1 1 Alalak, with an indication of the value of the learning outcomes of> 70% above. Increased social awareness of learning needs to be realized in the form of student attitudes in interaction with fellow students, the teachers and staff employees at the school.Keywords: Problem-based learning, media image, social awareness Kesadaran sosial terhadap orang lain dalam kehidupan sehari-hari bisa dimaknai manusia sebagai makhluk sosial, yaitu manusia yang peduli dengan sesama, saling berinteraksi, menghargai orang lain dalam hal perbedaan pendapat, suku, ras, bahasa dan agama. Dalam konteks pembelajaran dituntut suatu strategi yang direncanakan oleh guru dengan mengedepankan keaktifan atau kreativitas peserta didik dalam kegiatan belajar mengajar untuk bisa membentuk karakter kesadaran sosial dengan model pembelajaran Problem Based Learning (PBL) menggunakan gambar sebagai media.Jenis penelitian yang digunakan dalam Penelitian Tindakan Kelas (PTK). Desain penelitian mengacu pada model Kemmis & Mc. Taggart yang menggunakan sistem spiral refleksi diri yang dimulai dari rencana (plan), tindakan (act), pengamatan (observe), refleksi (reflect), dan perencanaan kembali yang merupakan dasar untuk langkah pemecahan masalah.Hasil penelitian menunjukkan jika aktivitas guru dalam proses pembelajaran   dari 75% menjadi 93,75%, Aktivitas siswa dari 77,5% menjadi 80,55%, dan ketentuan hasil belajar dari 63,34% menjadi 100%. Penerapan Problem Based Learning menggunakan media gambar dapat meningkatkan kesadaran sosial siswa kelas XI IPS 1 di SMA Negeri 1 Alalak, dengan indikasi nilai hasil belajar > 70% di atas KKM. Peningkatan kesadaran sosial dalam pembelajaran perlu diwujudkan dalam bentuk sikap siswa dalam berinteraksi dengan sesama siswa, dewan guru serta staf karyawan di sekolah.Kata Kunci : Problem based learning, media gambar, kesadaran sosial
MUSEUM LAMBUNG MANGKURAT SEBAGAI SUMBER PEMBELAJARAN SEJARAH
Authors: Ariwibowo Tri Hayat
Published: March 2020

This paper aims to determine the role of Museum Mangkurat as a source of teaching history. The method used in this paper is reinforced circuitry historical method of observation and literature. The survey results revealed that the Museum Mangkurat have a major role to education development. Especially in teaching and learning history. Museums and history simply can not be separated, because the election of the museum as a source of teaching history is very precise.Learners can learn firsthand by seeing, understanding and direct experience so that learning becomes enjoyable and meaningful. The learning process in this museum can be done using methods trips and CTL (Contextual Teaching and Learning). With the use of methods trips and CTL make history teaching more accepted by learners, leaving the impression of monotonous, boring and rote.Keywords: Museum, History, Field Trips, and CTL.Tulisan ini bertujuan untuk mengetahui peran Museum Lambung Mangkurat sebagai sumber pembelajaran sejarah. Metode yang digunakan dalam penulisan ini adalah metode sejarah yang diperkuat dnegan observasi dan studi pustaka.Dari hasil penelitian diketahui bahwa Museum Lambung Mangkurat mempunyai peran besar terhadap perkembangan pendidikan. Terutama dalam proses belajar mengajar sejarah. Museum dan sejarah memang tidak dapat dipisahkan, karena itu pemilihan museum sebagai sumber pembelajaran sejarah adalah sangat tepat.Peserta didik dapat belajar secara langsung dengan melihat, memahami, dan mengalami langsung sehingga pembelajaran menjadi menyenangkan dan bermakna. Proses belajar mengajar di museum ini dapat dilakukan dengan menggunakan metode karya wisata dan CTL (Contextual Teaching and Learning). Dengan penggunaan metode karya wisata dan CTL menjadikan pembelajaran sejarah lebih diterima oleh peserta didik, meninggalkan kesan monoton, membosankan dan hapalan.Kata Kunci: Museum, sejarah, karya wisata, dan CTL.
Health Locus of Control in Parents of Children with Leukemia and Associations with Their Life Perceptions and Depression Symptomatology
Authors: Tremolada Marta , Taverna Livia , Bonichini Sabrina , Putti Maria Caterina , Pillon Marta , Biffi Alessandra
Published: March 2020

Health locus of control is the set of beliefs a person has about his or her personal influence on health. The current study aimed at identifying types of locus of control in parents of leukemia children and possible association with depressive symptomatology and current life perception. 104 parents were recruited at the Haematology-Oncologic Clinic of Padua post 1 month from the leukemia diagnosis. Participants were Caucasian with a mean age of 37.28 years (SD=5.89), mostly mothers (87.5%) and with a mean of 12.16 years of education (SD=3.82). After signing the informed consent, they filled in the Ladder of Life questionnaire, the BSI-18 and the Parents Health Locus Of Control (PHLOC). Paired-samples t-test (t= -14.42; df=103; p=0.0001) showed that parents of leukemia children were more inclined to have an external locus of control than an internal one. Hierarchical regression analysis model (R2=0.34; F=4.32; p=0.0001) identified health professional influence (ß= -0.28; p=0.004), current life perception (ß= -0.3; p=0.013) and future life perception (ß= -0.26; p=0.012) as significantly predictors on Parental depression. Improving trust in the medical staff care and parental life perceptions could be a preventive program to cope with parental depression symptomatology.
Plasma Beam Dumps for EuPRAXIA Facility
Authors: Xia Guoxing , Bonatto Alexandre , Pizzato Nunes Roger , Liang Linbo , Jakobsson Oscar , Zhao Yuan , Williamson Barney , Davut Can , Wang Xueying
Published: March 2020

Beam dumps are indispensable components for particle accelerator facilities to absorb or dispose beam kinetic energy in a safe way. However, the design of beam dumps based on conventional technology, i.e. the energy deposition via beam-dense matter interaction, makes the beam dump facility complicated and large in size, partly due to nowadays’ high beam intensities and energies achieved. In addition, these high-power beams generate radioactive hazards, which need specific methods to deal with. On the other hand, the EuPRAXIA project can advance the laser-plasma accelerator significantly by achieving 1-5 GeV high quality electron beam in a compact layout. Nevertheless, the beam dump based on conventional technique will still produce radiation hazards and make the overall footprint less compact. Here, we propose to implement a plasma beam dump to absorb the kinetic energy from the EuPRAXIA beam. In doing so, the overall compactness of the EuPRAXIA layout will not be impacted, and the radioactivity generated by the facility can be mitigated. In this paper, results from particle-in-cell (PIC) simulations are presented for plasma beam dumps based on EuPRAXIA beam parameters.
Effects of in ovo Supplementation with Nano-nutrition (L-Arginine Conjugated with Ag NPs) on Muscle Growth, Immune Response and Heat Shock Proteins at Different Chicken Embryonic Development Stages
Authors: Subramaniyan Sivakumar , Darae Kang , Siddiqui Sharif Hasan , Park Jin Ryong , Tian Weishun , Byung Yong Park , Shim Kwan Seob
Published: March 2020

The aim of the study was to analyze the in ovo injection of chemically and biologically synthesized silver nano-particles (Ag NPs) using Brassica oleracea L. var capitate f. Rubra, (BOL) conjugation with L-Arginine (L-Arg) on the immune, muscle growth, survivability and hatchability of the broiler chickens. L-Arg (100 μg) conjugated with 1000 µg of Ag NPs synthesized by (BOL)-extract and L-Arg (100 μg) conjugated with 100 µg of Ag NPs chemically synthesized were injected into fertile eggs at 8d, 14d and 18d of incubation. Living embryo and hatched chicks were calculated. Survivability and hatchability were not affected by the injected dose of L-Arg (100 μg) with 1000 µg (BOL-Ag NPs) and L-Arg (100 μg) with 100 µg (C-Ag NPs) but it significantly improved when the eggs were injected on day 14 of incubation compared with those injected on days 8 or 18. Moreover, the protein expression of muscle development markers such as myogenin and myoD were significantly up-related in 14 d of incubation whereas the heat shock proteins (HSPs) such as HSP-60 and HSP-70 were significantly up-regulated in 18 d incubation. In addition, the in ovo injection on 18 d significantly increased the serum glutamate oxaloacetate transaminase (SGOT) and serum glutamate pyruvate transaminase (SGPT) as well the immunoglobulin (IgM) levels were increased in 14d incubation period in serum at the same concentration.
Digital Assets: The Idea of Indonesian Property Law Reform and Its Potential as a Collateral Object
Authors: Asmara Teguh Tresna Puja , Abubakar Lastuti , Handayani Tri
Published: March 2020

Digital assets in the broadest sense can be interpreted to cover all electronic assets including social media accounts. Nowadays, besides being used to interaction, social media accounts can also be utilized to gain income or material benefits. In addition, social media accounts are generally handled by influencers with abundant followers. One of the social media used by influencers on the internet is YouTube. The social media actors on YouTube are referred to as YouTubers or content creators. This research is a normative juridical legal research with the descriptive method of analysis. The result of the study shows that YouTube accounts as digital assets in practice can be used as assets in business activities. This is proven by the existence of a YouTuber or content creator who sells his account for charity or commercial purposes. In the future, YouTube accounts can potentially be a digital asset that can be used as a collateral object due to its economic value. Nevertheless, based on the property of law in Indonesia, YouTube social media accounts as a digital asset cannot be qualified as an asset yet, therefore a redefinition, a reconceptualization and a reform of the property of law are considered necessary.
Pengaruh Pengetahuan Mengenai Isu-Isu Lingkungan (Knowledge About Environmental Issues) dan Intensi Untuk Bertindak (Intention to Act) terhadap Perilaku Bertanggung Jawab Lingkungan (Responsible Environmental Behavior) Siswa
Authors: Fibula Purnama  , I Made Putrawan  , Diana Vivanti Sigit
Published: March 2020

Environmental issues is the problem that need to be solved by all parties, including students, by developing responsible of environmental issues. Students’ responsible environmental behavior is an output that came from factors that have effects toward it. Some of the effects are knowledge about environmental issues and intention to act. This study aims to determine the effect of knowledge about environmental issues and intention to act toward responsible environmental behavior that student have. This research conducted at SMAN 4 Kota Bekasi on the 1st semester, of 2019/2020 school year. The method of this research was survey method with quantitative-causal approach and path analysis. The sample of this research were 98 student grade X MIPA. The instrument for knowledge about environmental issues is a true-false test, the instrument for intention to act and responsible environmental behavior is opinionary. Realiability coefficients for knowledge about environmental issuess’ instrument is 0,77, for intention to act is 0,87, and for responsible of environmental behavior is 0,83. Based of hypothesis test, there is no direct effect between knowledge about environmental issues toward responsible environmental behavior, and there is direct effect between knowledge about environmental issues toward intention to act and intention to act toward responsible environmental behavior. Based on these results, can be concluded that intention to act is not a suitable mediator variable between knowledge of environmental issues and responsible environmental behavior.

 

Keywords: intention to act, knowledge, path analysis, responsible environmental behavior, student.
Hubungan Antara Orientasi Nilai (Value Orientation) dengan Paradigma Lingkungan Baru (New Environmental Paradigm) Siswa
Authors: Dwi Widyawati Amalia Fitri
Published: March 2020

The New Environment Paradigm is the result of interaction of various factors, one of which is the Value Orientation. This research discusses the relationship between the value orientation and the new environmental paradigm for high school students in Jakarta. This research was conducted at SMAN 22 Jakarta in Semester I Academic Year 2019/2020. The method used is a survey method with correlational techniques. The samples used were 100 students of class XI MIPA who were randomly selected. Data is collected using instrument value orientations and new environmental paradigms. Data analysis was performed with a simple linear regression test to measure the relationship used Pearson Product Moment at a significance level of 5%. The results showed a positive and significant relationship between the value orientation with the new environmental paradigm. The sample reliability for the nep variable was 0.857, while the reliability of the comparison of sample values ​​was 0.905. The orientation of the value of the contribution to the new environment paradigm variable was 38.7%. Egoistic has the highest contribution to nepian at breakdown because it involves factors such as the student environment and technology. Therefore value orientation has a role in looking at the paradigm of the new environment of students.

 

Kata Kunci : Value Orientation, New Environmental Paradigm, Students.
Supporting Local Skills and Enterprise Development – Lessons Learnt from a Public-Private Partnership in Eastern Africa
Authors: Kanichay Elvira , Dietsche Evelyn
Published: March 2020

Developers and operators of large-scale industrial projects are often faced with the challenge that host governments and communities expect such projects to transform and diversify the local economy and provide jobs and training opportunities for the local population. To support local employment and local sourcing of goods and services into and around the supply chain, the E4D/SOGA – Employment and Skills for Africa partnership program has brought together stakeholders from the energy and the development sector to deliver skills, supplier and enterprise development projects in East Africa. This paper reflects on this collaborative partnership. First, it introduces the program's objective, its point of departure and its achievements to date. Second, it explains the program's overall approach focused on promoting employment in collaboration with industry, and it sketches out the partnership options that it has offered to different types of companies. Third, it discusses three main lessons learnt focusing on the value of the program's multi-partnership approach, its delivery of short and longer courses improving beneficiaries’ employability and transferable skills, and the balance it has struck between supporting local companies to become suppliers and stimulating entrepreneurship to support more diversified local economies. The paper concludes with the overarching message that this partnership has struck a new balance: it has moved beyond conventional technical and vocational education and training (TVET) programs to focus on the shared interest that local communities and international companies have in promoting local employment.
Long-lasting insecticidal nets retain bio-efficacy after five years of storage: implications for malaria control programmes
Authors: Musa Jeremiah John , Moore Sarah , Moore Jason , Mbuba Emmanuel , Mbeyela Edgar , Kobe Dickson , Swai Johnson K. , Odufuwa Olukayode G.
Published: March 2020

Background: Long-lasting insecticidal nets (LLINs) are the most sustainable and effective malaria control tool currently available. Global targets are for 80% of the population living in malaria endemic areas to have access to (own) and use a LLIN. However, current access to LLINs in endemic areas is 56% due to system inefficiencies and budget limitations. Thus, cost-effective approaches to maximize access to effective LLINs in endemic areas are required. This study evaluated whether LLINs that had been stored for five years under manufacturer’s recommended conditions may be optimally effective against Anopheles mosquitoes, to inform malaria control programmes and governments on the periods over which LLINs may be stored between distributions, in an effort to maximize use of available LLINs. Methods: Standard World Health Organization (WHO) bioassays (cone and tunnel test) were used to evaluate the bio-efficacy and wash resistance of Olyset® and DawaPlus® 2.0 (rebranded Tsara® Soft) LLINs after five years of storage at 25°C to 33.4°C and 40% to 100% relative humidity. In addition, a small scale Ifakara Ambient Chamber test (I-ACT) was conducted to compare the bio-efficacy of one long stored LLINs to one new LLIN of the same brand, washed or unwashed. LLINs were evaluated using laboratory reared fully susceptible Anopheles gambiae sensu stricto (s.s.) (Ifakara strain) and pyrethroid resistant Anopheles arabiensis (Kingani strain). Results: After five years of storage, both unwashed and washed, Olyset® and DawaPlus® 2.0 (Tsara® Soft) LLINs passed WHO bio-efficacy criteria on knockdown (KD60) ≥95%, 24-hour mortality ≥80% and ≥90% blood-feeding inhibition in WHO assays against susceptible An. gambiae s.s. DawaPlus® 2.0 LLINs also passed combined WHO bioassay criteria against resistant An. arabiensis. Confirmatory I-ACT tests using whole nets demonstrated that long-stored LLINs showed higher efficacy than new LLINs on both feeding inhibition and mortality endpoints against resistant strains.Conclusions: Even after long-term storage of around 5 years, both Olyset® and DawaPlus® 2.0 LLINs remain efficacious against susceptible Anopheles mosquitoes at optimal storage range of 25°C to 33.4°C for temperature and 40% to 100% relative humidity measured by standard WHO methods. DawaPlus® 2.0 (Tsara® Soft) remained efficacious against resistant strain.
Incidence of injuries and illness and related risk factors in mountain biking events: A systematic review protocol
Authors: Buchholtz Kim , Lambert Mike , Burgess Theresa
Published: March 2020

Background
Cycling is a popular sport and method of transportation globally but is a significant contributor to sports injury admissions in hospital emergency units. Mountain biking events present additional challenges with remote venues, and isolated courses. Most mountain biking events will provide on-site medical care for both injury and illness occurring during races. These data are essential to understand the true incidence of injury and illness in mountain biking events as national health data may not represent these unique events specifically.

Methods
This review will follow the preferred reporting items for systematic reviews and meta-analysis (PRISMA) statement. Search engines PubMed, Scopus, SPORTDiscus (EBSCOhost), PEDro and the Cochrane Library will be systematically searched. Gray literature searches of Google Scholar and manual searching of reference lists and congress abstracts from cycling specific congresses will be conducted. Journal articles documenting illness and injury in adults participating in mountain bike cross-country marathon events will be included. A narrative analysis of the types, severity and area of injuries; and illness type and severity will be performed. A quantitative analysis may be performed should there be sufficient studies reported in the same format.

Discussion
This protocol outlines a systematic review on injury and illness in mountain biking events. Data from hospital records may not adequately represent the burden of injury and illness at events held in remote venues, especially if those treated on site do not require further hospital based treatment. This review will assist with the development of further research in this area, and in preparation of clinicians working in these types of events.
Systematic review registration: This protocol has been registered with PROSPERO International prospective register of systematic reviews (No: CRD42019134586).
Analysis of renal lesions in Chinese tuberous sclerosis complex patients with different conditions of TSC1/2 genetic mutations
Authors: Wang Wenda , Zhao Yang , Wang Xu , Wang Zhan , Zheng Guoyang , Cai Yi , Fan Hua , Li Hanzhong , Zhang Yushi
Published: March 2020

Objective The renal manifestations of tuberous sclerosis complex (TSC) are complicated and various. We’d like to report the information of genetic mutations in TSC patients with renal lesions, and to discuss the relationship between features of renal lesions and genetic mutations, including mutant genes and mutant types.
Methods TSC patients with renal lesions who came to Urology Department of our hospital from January 1st, 2015 to January 1st, 2020 were retrospectively analyzed. TSC patients who received next generation sequencing (NGS) of TSC1/2 and imaging examinations were screened out. When familial TSC patients were confirmed, only the probands were included. The patients who had imaging evaluation in our hospital before any treatment for TSC renal angiomyolipomas (AMLs) were also selected for further analysis of relationship between genetic mutations and AML sizes.
Results 70 clinically or genetically diagnosed TSC patients with renal lesions were included. The average age was 29.3±8.3 years old. Male-female ratio was 1:1.5. 15 patients (21.4%) were probands of TSC families (3 TSC1 , 10 TSC2 , and 2 NMI). 67 patients (95.8%) had bilateral renal AMLs with one patient had a pathological diagnosis of epithelioid AML ( TSC2 mutation). One patient had multiple renal cysts ( TSC2 mutation), one had renal cell carcinomas (RCCs) ( TSC1 mutation) and one had Wilms tumors ( TSC1 mutation). Among the 70 included patients, 4 patients had TSC1 mutations, 51 had TSC2 mutations, and 15 had no mutation identified (NMI). There was no statistically significant difference between TSC2 mutations and NMI groups (11.4±5.7 vs. 8.0±5.6cm, P = 0.077) when considering AML sizes. There was also no statistically significant difference among AML sizes of patients with TSC2 mutation types of nonsense, missense, frameshift, slipping, and fragment deletion ( P = 0.712). And no statistically significant difference was found between maximus diameters in familial and sporadic patients, either (11.4±5.8 vs. 10.5±5.8, P = 0.663).
Conclusions The conditions of TSC genetic mutations will affect type and severity of renal lesions. Other focuses such as protein structure and function need to be studied for renal manifestations. Except for patients with TSC1 and TSC2 genetic mutations, patients with NMI and familial patients are also needed more attention for the pathogenesis of them is still unknown.
Mechanism and molecular network of RBM8A-mediated regulation of oxaliplatin resistance in hepatocellular carcinoma via EMT
Authors: Lin Yan , Liang Rong , Zhang Jinyan , Liu Zhihui , Liu Ziyu , Li Qian , Luo Xiaoling , Li Yongqiang , Ye Jiazhou
Published: March 2020

Epithelial-mesenchymal transition (EMT) has been shown to be closely associated with Oxaliplatin (OXA) resistance. Previous study found that RBM8A is highly expressed in HCC and induce EMT, suggesting that it may be involved in the regulation of OXA resistance in HCC. However, the accurate mechanism has not been concluded. In our study, ectopic expression and silencing of RBM8A were performed to explore its function. The OXA resistance potential of RBM8A and its downstream pathway was investigated using in vitro and in vivo models. The results showed that RBM8A overexpression induced EMT in OXA-resistant HCC cells, thereby affecting cell proliferation, apoptosis, migration, and invasion and promoting OXA resistance in vivo and in vitro. Moreover, whole-genome microarrays combined with bioinformatics analysis revealed that RBM8A has a wide range of transcriptional regulatory capabilities in drug-resistant HCC, including the ability to regulate several important tumor-related signaling pathways. Histone deacetylase 9 (HDAC9) is an important mediator of RBM8A activity related to OXA resistance. These data suggest that RBM8A and its related regulatory pathway represent potential markers of OXA resistance and therapeutic targets in HCC.
Intrathoracic infusion therapy of thymic peptides and chemical irritants for malignant pleural effusion: a meta-analysis of 24 randomized controlled trials
Authors: xiao zheng , Wang Cheng-Qiong , He Min , Shen You-Shu , Zheng Xiao-Tian , He Yuan-Xiu , Yang Ya-Hui , Fan Teng-Yang , Li Shu-Guang , Chen Xiao-Fan , Feng Ji-Hong , Xiao Xue , Yao Xing-Sheng
Published: March 2020

Background: To further determine the clinical efficacy and survival of intrathoracic infusion with TPs and chemical irritants and their therapeutic threshold and optimal control regimen to achieve a desired response in malignant pleural effusion (MPE). Methods: We collected all randomized controlled trials (RCTs) of TPs with chemical irritants from Chinese and English databases (from inception until September 2019), and performed a new meta-analysis following the PRISMA guidelines. We measured their bias risk, summarized data using meta-analysis, and evidence quality using the Grades of Recommendation Assessment, Development and Evaluation approach. Results: We collected 24 trials involving three TPs and platinum and 1,592 patients. Most trials had unclear bias risk. TPs with platinum significantly improved complete response [4.02 (3.12 to 5.18)] and quality of life [3.64 (2.34 to 5.66)], the 0.5-year overall survival (OS) rate [5.75 (3.02 to 10.92)], and 1-year OS rate [5.29, (1.71 to 16.36)], and reduced the treatment failure, myelosuppression, and gastrointestinal toxicity. For patients with moderate to large volume of pleural effusion, KPS score ≥50 to 60, or AST ≥3 months, the thymosin (200–300mg/time), thymopentin (2mg/time) or thymosin alpha 1 (3.2mg/time) with cisplatin (30–40mg/m 2 ), carboplatin (400mg/m 2 ), or oxaliplatin (100mg/m 2 ) are possible regimens for achieving a desired success, and low failure. Most results were robust and moderate quality. Conclusion: The moderate evidence suggests that the TPs with platinum is beneficial to the patient with MPE, and provides evidence for the therapeutic threshold and possible regimens that may achieve a desired success and reduce the failure.
Efficacy of Dao Yin in patients with 2019 novel coronavirus pneumonia: study protocol for a randomized controlled trial
Authors: Zhang Shuaipan , Lv Zhizhen , Zhu Qingguang , Sun Wuquan , Yao Fei , Fang Lei , Kong Lingjun , Cheng Yanbin , Wu Zhiwei , Fang Min
Published: March 2020

Background The epidemic of 2019 novel coronavirus (2019-nCoV) pneumonia has become a focused public health event in world. The authorities have taken prompt medical action in China, which contained strict isolation measures and potential symptomatic supportive care. Dao Yin, a traditional Chinese exercise, combines limb movements and breathing exercises. Previous researches showed that it can activate the immune system and improve the lung function and the mental state of patients. Therefore, there may be a potential effect of Dao Yin on the physical and mental health of patients with 2019-nCoV. The aim of this trail is to verify whether conventional therapy plus Dao Yin could show better effects for 2019-nCoV than conventional therapy alone.Methods/design The study is a multicenter randomized controlled trial with parallel-group design including two intervention groups: a conventional therapy group and a conventional therapy plus Dao Yin group. A total of 186 eligible participants will be randomly assigned to the groups in a 1:1 ratio. The routine treatment of the two groups is performed daily according to guideline, and Dao Yin is performed once a day until the patient is out of the hospital. The primary outcome is the Length of Hospital Stay (LHS). Secondary outcomes include the vital signs, respiratory symptoms, questionnaire of mental health and the quantity of immune cells. The outcomes will be assessed at five points including the baseline, 3th, 6th, 9th day during hospitalization and the discharge day. The significance level is 5%. This study will focus on the value of a conventional therapy plus Dao Yin as the treatment for 2019-nCoV and will explore any potential connection among the outcomes.Discussion This study may evaluate the efficacy of conventional therapy plus Dao Yin for 2019-nCoV, which can contribute to provide a solid evidence of Dao Yin therapy for the nationwide emergence.Trial registration: Chinese Clinical Trial Registry, ChiCTR2000029978 Registered on 18 February 2020.
Predisposing Conditions and Etiology of Pediatric Recurrent Bacterial Meningitis in Beijing Children's Hospital, 2006-2018
Authors: Chen Tian-ming , Chen He-ying , Hu Bing , Hu Hui-li , Guo Xin , Guo Ling-yun , Li Shao-ying , LIU GANG
Published: March 2020

Objective To investigate the predisposing conditions, etiology and clinical characteristics of recurrent bacterial meningitis (RBM) in children.Methods Seventy patients of RBM treated in Beijing Children's Hospital from January 2006 through December 2018 were retrospectively analyzed.Results Predisposing conditions of RBM include: inner ear malformations 24(34.3%), dermal sinus tracts 15(21.4%), head trauma 15(21.4%), meningoencephalocele 12(17.1%), and immune deficiency 4(5.7%). Sixty-seven occasions of meningitis had positive bacterial cultures. Thirty-one occasions of Streptococcus pneumoniae ( S. pneumonia ) meningitis and 3 occasions of Haemophilus influenzae type b (Hib) meningitis occurred in the 24 patients with inner ear malformations; Seventeen occasions of S. pneumonia meningitis occurred in the 15 patients with head trauma, while 8 occasions of S. pneumonia meningitis in 12 patients with Meningoencephalocele; There were 2 Enterococcus faecalis meningitis, 1 Escherichia coli meningitis and 1 Staphylococcus aureus meningitis in 15 patients with dermal sinus tracts; Two of 4 patients with immune deficiency suffered S. pneumoniae meningitis.Conclusions Predisposing conditions of RBM in children include inner ear malformations, head trauma, meningoencephalocele, dermal sinus tracts, and immune deficiency. The most common etiology of RBM with inner ear malformation, head trauma, meningoencephalocele, and immune deficiency is S. pneumoniae . Empiric antibiotic treatment of RBM in children should cover S. pneumoniae.
Correlation between Anti-Mullerian Hormone Levels and Antral Follicle Numbers in Polycystic Ovary and Metabolic Syndromes
Authors: Fu Huo , Lin Youshi , Deng Xueqing , Wu Lin
Published: March 2020

Background Anti-Mullerian hormone (AMH) is expressed by granulosa cells of the pre-antral and small antral follicles in the ovary. Serum AMH levels are significantly higher in women with polycystic ovary syndrome (PCOS) due to an increased number of antral follicles and also a higher production per antral follicle. We proposed diagnostic criteria for the identification of PCOS that are based on variation in the AMH concentrations.Methods This study explored the relationship between serum AMH levels and other hormonal markers in patients with polycystic ovary syndrome (PCOS) and metabolic syndrome. One hundred fifty patients with PCOS and normally cycling women were examined in a cohort study. Of these, some were candidates for the assisted reproductive methods. The following serum levels were measured in all patients on day 5 of the menstrual cycle: AMH, glucose, HOMA/IP, BMI, testosterone and cholesterol, lipoproteins and triglycerides.Results In the PCOS group, a 2-fold increase in the serum AMH level was observed as compared to the controls. With AMH, the following increments were seen: testosterone (by 184%); fasting blood glucose (by 18%); fasting insulin (83.86%); HOMA/IR (by 64.23%); mean cholesterol (by 30%); mean triglycerides (by 17%); and BMI (by 26.75%). The high-density lipoprotein concentration decreased by 29.3%.Conclusion Thus, monitoring the level of AMH allows predicting for OHSS during the ovulation induction and during the use of assistive reproductive technologies. Such a practice also allows deciding on the treatment strategy for obesity, hirsutism, type II diabetes, infertility and cardiovascular diseases.
Two-step transurethral resection of bladder tumor can result in a better surgical quality and lower recurrence in patients with non-muscle invasive bladder cancer: a retrospective study
Authors: Huang Wei-Lun , Huang Chao-Yuan , Huang Kuo-How , Pu Yeong-Shiau , Chang Hong-Chiang , Chow Po-Ming
Published: March 2020

Background Current protocols for transurethral resection of bladder tumor (TURBT) are still unstandardized, and outcomes are also uneven in different protocols. In our medical center, we performed two-step TURBT that the resection of bladder tumor is made in two steps- exophytic parts first and tumor bases second. The purpose is to improve tumor eradication and increase detrusor muscle sampling rates. The aim of current study is to evaluate clinical outcomes and detrusor muscle sampling rate of two-step TURBT in patients with non-muscle invasive bladder cancer (NMIBC). Methods We conducted a retrospective review from a prospective database. From January 2012 to December 2017, patients who had newly diagnosed NMIBC with a follow-up period of more than 2 years were enrolled. Patients with concomitant or subsequent upper urinary tract urothelial carcinoma (UTUC) were excluded. Patients were categorized into the two-step TURBT (TR) and the conventional TURBT (CR) groups. The primary endpoints were recurrence and progression rates. The secondary endpoints were recurrence-free survival (RFS), progression-free survival (PFS), and the detrusor muscle sampling rate. Results There were 205 patients included in our study, with 151 patients in the TR group and 54 patients in the CR group. The median follow-up period was 40.5 months. There were lower recurrence rate ( P = 0.015), higher detrusor muscle sampling rate ( P = 0.043), and better RFS (Log-Rank P= 0.007) in the TR group. Two-step TURBT was also associated with better RFS in both univariate ( P =0.009) and multivariate ( P =0.003) Cox proportional hazards regression. Conclusions In patients with NMIBC, Two-step TURBT results in higher detrusor muscle sampling rate and better disease outcomes. The findings suggest that Two-step TURBT is a better surgical method for treating NMIBC.
Evaluation of the Iron Aid Program Process in Iranian girls' high school: A national study
Authors: Alami Ali , Hosseini Zahra , Tehrani Hadi , Jafari Alireza
Published: March 2020

Background: One of the most important health and social problems in adolescent girls is iron deficiency anemia. The purpose of this study was to evaluate the Iron Aid National Program for high school girls.Methods: This cross-sectional study was performed on cluster random sampling from northern, southern, eastern, western and central regions of Iran with a sample size of 399 high school girl students. A valid and reliable researcher-made questionnaire was used for data collection. Data were analyzed by SPSS 20 software.Results: The most important reasons for not taking iron supplements from the students' viewpoints were the bad taste of iron supplements, nausea after consumption, non-prescription of the iron supplement by a physician. Most students believed that inviting health professionals and film/video screenings had the most impact on encouraging them to intake iron supplements. About 45 % of students reported that they had no training program on iron supplementation, and only 28 % of students received educational content. Also, 71 % of students said there were not enough glasses for the consumption of supplement iron. There was a significant relationship (p <0.05) between the person distributing the supplements in the schools, the availability of adequate drinking water, the time allocated to the implementation of the program, and the person teaching the program with the number of supplements consumed by the students (p <0.05).Conclusion: Based on the results of this study, attention was paid to different aspects of the Iron Aid National Program such as providing quality supplements, providing appropriate environmental conditions, designing training programs, public information and providing appropriate human resources for successful implementation of Iron Aid National Program are essential.
Breakfast consumption is inversely associated with metabolic syndrome in a sample of Iranian adults
Authors: Lorzadeh Elnaz , Sangsefidi Zohreh Sadat , Mirzaei Masoud , Hosseinzadeh Mahdieh
Published: March 2020

Background: Central obesity, insulin resistance, dyslipidemia and hypertension are the core components of metabolic syndrome (MetS) which is coincident with unhealthy dietary habits in the Middle-Eastern countries. The aim of this study was to explore the association between dietary habits and metabolic syndrome of adult population living in Yazd Greater Area, Iran. Methods: This is a cross-sectional study which uses the data of a population-based cohort study on Iranian adults, known as Yazd Health Study (YaHS). The relationship between dietary habits and metabolic syndrome among adults (n= 2896) were analyzed using multiple logistic regression method. Results: Outcomes from logistic regression examining show that breakfast consumption has a significant inverse effect on the occurrence of metabolic syndrome after adjustment for age, education level, physical activity statue, history of chronic diseases and smoking (odds ratio (OR)= 0.38, 95% confidence interval (CI)= 0.14, 0.97). This effect remains significant even after adjustment for body mass index (BMI) and reveals that odds of having MetS is 69 % lower in breakfast consumers in contrast to non-consumers (OR=0.31, 95% CI= 0.11, 0.87). However, no significant relationship was observed between other dietary habits and MetS after adjustment for all potential confounders Conclusions: This study revealed that eating breakfast has an inverse relationship with metabolic syndrome. Finding out stronger evidence in relation between dietary habits and metabolic syndrome, more researches especially population-based cohort studies are needed to be conducted.
Cross-protective immunity of the hemagglutinin stalk domain presented on the surface of Lactococcus lactis against divergent influenza viruses in mice
Authors: Lei Han , Gao Tong , Cen Qianhong
Published: March 2020

Background Most of the current approaches to influenza vaccine design focus on antibodies against influenza hemagglutinin (HA). However, these influenza vaccines typically provide strain-specific protection against mostly homologous subtypes. There is an urgent need to develop a universal vaccine that confers cross-protection against influenza viruses. Of note, the HA stalk domain (HAs) is a new target for such an influenza vaccine.Results Recombinant L.lactis/pNZ8150-pgsA-HAs constructed in which pgsA was used as an anchor protein and investigated the immunogenicity of HAs, in the mouse model by oral administration without the use of a mucosal adjuvant. Mice were orally vaccinated with L.lactis/pNZ8150-pgsA-HAs, and then produced significant humoral and mucosal immune responses. Importantly, L.lactis/pNZ8150-pgsA-HAs provided significant cross-protection against H5N1, H3N2 or H1N1 virus infection.Conclusions Our data support the hypothesis that HAs presented on the surface of L. lactis can provide cross-protective immunity against influenza A viruses. Taken together, these findings suggest that L.lactis/pNZ8150-pgsA-HAs can be considered an alternative approach to developing a novel universal vaccine during an influenza A pandemic.
Yersinia enterocolitica enteritis versus other bacterial enteritis in ultrasonic findings: a single-center case control study
Authors: Miyata Eri , Jimbo Keisuke , Kyoudo Reiko , Kudo Takahiro , Shimizu Toshiaki
Published: March 2020

Background: Yersinia enterocolitica (Ye) causes enteritis with mesenteric lymphadenitis and terminal ileitis, and can be difficult to distinguish from acute appendicitis, especially in children. In addition, because detection from stool culture is more difficult for Ye than for other bacteria causing enteritis, the diagnosis of Ye enteritis is not easy. Abdominal ultrasonography is useful for diagnosing bacterial enteritis, including Ye enteritis. This study diagnosed Ye enteritis and other bacterial enteritis by stool culture and compared and analyzed the ultrasonic findings and clinical features in children. The aims of this study are to compare and analyze ultrasonic findings and clinical features in children with Ye enteritis and other bacterial enteritis.Methods: Participants in this retrospective study comprised all 34 bacterial enteritis patients (3-18 years old) treated between 2014 and 2017. Patients were divided into the Yersinia enterocolitica enteritis (Ye) group and other bacterial enteritis (non-Ye) group from whom other pathogens were detected. Ultrasonic findings (including maximum and minimum diameters of ileocecal lymph nodes (C-LNs), mean major/minor axis ratio, wall thickness of the terminal ileum, and presence of a pericecal hyperechoic region) and blood examinations at first visit were compared between two groups. Results: The Ye group included 13 patients and the non-Ye group included 21 patients. Mean C-reactive protein level was higher in the Ye group (5.9±3.0 mg/dL) than in the non-Ye group (2.7±3.4 mg/dL, p = 0.049). No difference in mean maximum diameter of C-LNs was seen between two groups. However, mean C-LN major/minor axis ratio was lower in the Ye group than in the non-Ye group (p = 0.002) and terminal ileal wall thickness value was higher in the Ye group than in the non-Ye group (p = 0.004). Pericecal hyperechoic region was more frequent in the Ye group than in the non-Ye group (p = 0.021). Conclusion: The combination of characteristic ultrasonic findings identified in this study may improve ultrasonic differentiation of Yersinia enterocolitica enteritis and other bacterial enteritis.
Higher education institutions as a driver of sustainable social development: Polish experience for Ukraine
Authors: Khovrak Inna
Published: March 2020

The basis for sustainable and environmentally friendly development is gradually becoming aware of the importance of working more ethically and transparently and in a more humanistic way, as well as addressing the needs of people and society. In this case, the key challenge for higher education institutions (HEIs) is to train the conscious and responsible citizens who can take care of the country’s future. This article focuses on comparing the ability of HEIs in Poland and Ukraine to promote sustainable development (SD) by implementing the concept of social responsibility (SR). The research is based on the methods of statistical analysis, sociological survey, case study, abstract-logical, tabular and graphical method. The paper argues that HEIs have a wide range of tools to promote SD. These tools should be divided into three groups, namely: 1) including SD issues in educational programs; 2) developing knowledge and solutions for SD; 3) creation and participation in SR initiatives. The proposed mechanism of the impact of HEIs on SD through the implementation of the concept of SR will allow HEIs to take an active part in the life of the region and the country, namely: identify the needs, engage the stakeholders, facilitate the interaction, disseminate the effective practices, and develop SD strategies. The practical value of the obtained results is that the implementation of SR initiative by HEIs will promote the environmentally friendly development of the country and regions. As a result, it will increase the impact of HEIs on economic, technology and cultural development, human capital formation, solving social problems, building civil society, improving the environmental status.
Application of the marketing mix to the world export of animal products
Authors: Vasylieva Natalia , James, Jr. Harvey
Published: March 2020

Agricultural trade is complicated owing to perishable goods and high requirements for safety and quality, especially by animal products. Intensifying their exports is a major priority in the context of augmenting competitive negotiations and providing global food security to cover a shortage of an animal protein intake. To address such challenges, this study aimed at improving marketing performance necessary for developing the world exports of animal products. The methodological research framework was the Marketing Mix model, which included Product, Price, Place, and Promotion, and was amplified by Innovation. The model components were presented by the average export prices and indicators for Infrastructure, ICT adoption, and Innovation capability evaluated for each exporting country. For testing hypotheses about homo- and heterogeneity of top exporters, this research utilized the single factor Analysis of Variance (ANOVA) technique. The offered approach was applied to the most valuable export segments of poultry, livestock, and dairy world markets. They engaged from 75 to 140 countries and had total export values between USD 3.2 billion and USD 33.2 billion. The study outcomes captured similarities and differences of Price, Place, Promotion, and Innovation components among the First 10, Second 10, and Third 10 ranked exporters. Given the found indicators of the top world exporters, the study clarifies prospects and attainable goals on developing exports of animal products at a country level.
The effect of announcement as the host of XVIII Asian Games on the Indonesian stock market
Authors: Andreas  , Ary Gumanti Tatang , Nurjannah Uliya , Nurul Awwaliyah Intan
Published: March 2020

In 2014, Indonesia was announced to be the host the 2018 XVIII Asian Games, the biggest sports event in Asia. This announcement is expected to positively impact the country’s economy and investors as there would be thousands of spectators from both the country and overseas. A direct impact of the event is that Indonesia would prepare the entire venue. This study examines whether the capital market participants react to the announcement. For this purpose it tests a total of 25 companies in the infrastructure, utility, and transportation sectors listed on the Indonesia Stock Exchange. A standard event study methodology is employed to examine the existence of abnormal returns around the event. The results show the abnormal returns on two days before and two days after the announcement. However, overall, there are no significant abnormal returns before and after the announcement. The study does not find a significant difference of abnormal returns before and after the announcement. Besides, there was no difference in trading volume activity before and after the announcement as the host of the XVIII Asian Games. In summary, the capital market participants do not consider the event to be a significant issue that determines their investment decision in the capital market.