bluuebunny/crossref_metadata_2025 huggingface dataset:
Predicting results of intra-sinus implantation
Authors:   Novokuznetsk State Institute for Advanced Training of Doctors – branch DPO RMAPO  Novokuznetsk, 654027, Russia, Likhanova М. А. , Sivolapov К. А. ,   Novokuznetsk State Institute for Advanced Training of Doctors – branch DPO RMAPO  Novokuznetsk, 654027, Russia
Published: July 2021

The study included 564 patients with a deficit in the volume of bone tissue of the alveolar process of the maxillary bone, which did not allow simultaneous installation of crestal implants. The work was carried out relying on modern forecasting systems based on an aggregate and quantitative assessment of the risk of intra- and postoperative complications, anatomical and physiological state of tissues and organs in the area of intervention. In the course of the study, a system for predicting the results of subaxillary augmentation was developed. Factors affecting the nature and frequency of complications in the immediate and long-term postoperative periods are highlighted. A comparative assessment of the functioning of the mucociliary clearance depending on the volume and location of the augmentate is given. Functional methods of investigation – spiral computed tomography and cone-beam computerized tomography – of maxillary bones, video endoscopy of the nasal cavity, study of mucociliary clearance, anterior active rhinomanometry were used. The assessment of the state of the augmentate, pneumatization of the maxillary sinuses, the anatomy of the nasal cavity, paranasal sinuses, the state of the maxillary sinus mucosa, the vertical volume of the walls of the maxillary sinus, and the evacuation capacity of the maxillary sinuses were evaluated. A score was determined for each of the studied parameters. Patterns of preoperative changes in the maxillary sinuses that led to complications in the postoperative period were identified. For each of these parameters, the amount of points collected can range from 1 to 5 points. The higher the score, the higher the probability of successful surgical treatment. If the sum of points is from 1 to 2, forecast of subaxillary augmentation is unfavourable, for 3 points is questionable, with a score of 4–5, the prognosis is favourable.
Testing hypothesis about incidence of information-significant symptoms in patients with chronic allergic, chronic vasomotor and chronic mixed rhinitis
Authors:   Tver State Medical University, Tver, 170100, Russia, Portenko G. M. , Shmatov G. P. ,   Tver State Technical University, Tver, 170036, Russia
Published: July 2021

A mathematical model of the neural network has been used to classify sick women with diagnosed allergic and vasomotor rhinitis in three forms: allergic rhinitis (ARhinitis), vasomotor rhinitis (VRhinitis) and mixed rhinitis (MRhinitis). When checking the incidence, the information-significant symptoms that we identified in the categories «Complaints» and “Objective status”, it was found that these symptoms are present in all forms of rhinitis and many of them are indistinguishable by the frequency of occurrence. These three forms of rhinitis with a triad of symptoms can be interpreted as an allergic disease of the nasal mucosa. Mixed rhinitis for the majority of information-significant symptoms in these two categories should be attributed to local allergic rhinitis (LAR). The full manifestation of information-significant symptoms in some patients depends on the duration of the disease and the individual characteristics of the body, which affects the diagnosis of allergic rhinitis and local allergic rhinitis. The term “Vasomotor rhinitis” should be excluded and interpreted as allergic rhinitis. We have convincingly proved that vasomotor rhinitis is a synonym for allergic rhinitis and is treated according to the standard of allergic pathology of the body. At present it is necessary to distinguish two forms of allergic rhinitis: allergic rhinitis, and local allergic rhinitis, depending on the identified information-significant symptoms in the patient at the time of the visit to the doctor.
Safety and efficacy assessment of MRI in cochlear implant patients with retained magnets
Authors:   Saint Petersburg Research Institute of Ear, Throat, Nose and Speech,  Saint Petersburg, 190013, Russia, Dvoryanchikov V. V. , Kuzovkov V. E. ,   Saint Petersburg Research Institute of Ear, Throat, Nose and Speech,  Saint Petersburg, 190013, Russia, Tsutsieva S. Kh. ,   Saint Petersburg Research Institute of Ear, Throat, Nose and Speech,  Saint Petersburg, 190013, Russia, Levin S. V. ,   Saint Petersburg Research Institute of Ear, Throat, Nose and Speech,  Saint Petersburg, 190013, Russia, Sugarova S. B. ,   Saint Petersburg Research Institute of Ear, Throat, Nose and Speech,  Saint Petersburg, 190013, Russia, Il’in S. N. ,   Saint Petersburg Research Institute of Ear, Throat, Nose and Speech,  Saint Petersburg, 190013, Russia, Levina E. A. ,   Saint Petersburg Research Institute of Ear, Throat, Nose and Speech,  Saint Petersburg, 190013, Russia, Nozdrevatykh O. V. ,   Saint Petersburg Research Institute of Ear, Throat, Nose and Speech,  Saint Petersburg, 190013, Russia, Lilenko A. S. ,   Saint Petersburg Research Institute of Ear, Throat, Nose and Speech,  Saint Petersburg, 190013, Russia
Published: July 2021

Most patients with CI need to undergo radiation diagnostics during their lifetime, including magnetic resonance imaging (MRI) and computed tomography (CT). Modern cochlear implants are currently compatible with MRI up to 1.5 T. However, clinics conducting magnetic resonance imaging studies may refuse to diagnose. This is due to the fact that during the study, the MRI scanner will act on the magnet of the implant and this can lead to such complications as migration of the implant, its demagnetization, and pain. These doubts determined the goal of our study - to assess the safety and effectiveness of magnetic resonance imaging (MRI) with a magnetic field power of 1.5 T in patients with cochlear implants (CI). We analyzed MR images of 11 patients who were followed up at the St. Petersburg Research Institute of Ear, Throat, Nose and Speech from 2014 to 2020, diagnosed with bilateral sensorineural hearing loss, grade IV, condition after CI. A questionnaire was conducted to determine the side effects of the study and to assess the diagnostic effectiveness of the method by several radiologists. In order to prevent possible complications, an external, tight-fitting pressure bandage was applied to all patients, and a plastic splint was installed in the projection of the implant in the bandage. During the study, the orientations of the magnetic fields of the MRI scanner (B0) and the implant (B1) were considered. The analysis of the obtained results showed that the MRI procedure with a magnetic field power of 1.5 T in patients with CI was not accompanied by any complications for patients and a negative effect on the implant. It is important to note that the diagnostic efficacy of the MRI results was maintained.
Kobiece oblicza: czarostwo i melancholia. Kilka refleksji na temat postrzegania psychoz społecznych dawniej i dziś
Authors: Kąkolewski Igor
Published: July 2021

Celem autora artykułu była interpretacja prowadzonych w epoce wczesnej nowożytności dyskursów na temat czarostwa i chorób psychicznych z punktu widzenia procesów ekskluzji i inkluzji jako mechanizmów regulujących dynamikę społeczną w określonych warunkach historycznych. Intelektualnym fundamentem wywodów w dyskursach na temat czarostwa i chorób psychicznych było tradycyjne przekonanie o rzekomej słabości i skłonności natury kobiecej do stanów kojarzonych z melancholią, rozumianą zarówno jako zjawisko naturalne (temperamentalne), jak i o podłożu demonicznym. Rozpowszechniane w dyskursie intelektualnym mizoginiczne poglądy o czarownicach, obecne również w dyskursie o melancholii jako przypadłości głównie kobiecej, pozwalały konstruować wyobrażenie o zagrażającej „większości” wiernych niebezpiecznej „mniejszości” czarownic (i czarowników), którą dodatkowo marginalizowano poprzez ich asocjację z religijną i etniczną „obcością”.
Procesy o magię i czary w Pradze w XVI i pierwszej połowie XVII stulecia
Authors: Kreuz Petr
Published: July 2021

Początki procesów o magię i procesów o czary w Pradze należy datować na koniec XV w. W okresie od objęcia tronu czeskiego przez Habsburgów (1526) do bitwy na Białej Górze (1620) można udokumentować jedynie pojedyncze przypadki procesów o praktyki magiczne w Pradze. Jest to o tyle symptomatyczne, że w ostatniej tercji XVI w. wyraźnie zauważalny jest wzrost liczby procesów o magię na ziemiach czeskich, a odnotowano też wówczas pierwsze, odosobnione jeszcze przypadki czarostwa. Jeden z procesów odbył się przed sądem Małej Strany (Mniejszego miasta praskiego) w 1553 r., a powodem w nim był królewski rusznikarz i ludwisarz Tomáš Jaroš. Poważniejsze sprawy dotyczące oskarżeń o magię i czary miały miejsce w Pradze dopiero w czasie wojny trzydziestoletniej. W 1624 r. cztery kobiety z Pragi-Hradczan zostały oskarżone o stręczycielstwo i uprawianie praktyk magicznych. Jedna z nich została skazana na wypędzenie z Pragi. W 1630 r. na Starym Mieście przeprowadzono dochodzenie przeciwko Marianie Příhodovej, żonie murarza, która została oskarżona o uprawianie magii i zabobonnych praktyk. Została jednak uniewinniona przez Sąd Apelacyjny. W 1631 r. Ludmiła Husáková została aresztowana na Nowym Mieście w Pradze pod zarzutem uprawiania magii, znachorstwa i wróżbiarstwa. Była ona więziona i przesłuchiwana przez prawie pół roku. Z więzienia została zwolniona dopiero po zdecydowanej interwencji jej pani, hrabiny Anny Benigny von Fürstenberg. Największa praska sprawa o czary w czasie wojny trzydziestoletniej odbyła się w 1644 r. Wówczas to specjalna komisja przeprowadziła dochodzenie w sprawie 19 chłopców z Pragi w wieku od 8 do 17 lat za rzekome wywoływanie diabła w szkole jezuickiej na Małej Stranie.
A Case of Free Flap Reconstruction after Endoscopic Debridemnt for Recalcitrant Nasopharyngeal Osteoradionecrosis Without Facial Incision
Authors: Kang Yung Jee , Hong Sang Duk , Chung Man Ki
Published: July 2021

High-dose radiation therapy is the treatment of choice for nasopharyngeal cancer, and clinical outcomes have improved in recent decades. A certain proportion of patients, however, suffer from post-radiation nasopharyngeal necrosis (PRNN). Patients with PRNN complain of headache, foul odor, or symptoms of cranial nerve palsies. Clinically, intracranial infection or bleeding from carotid artery damage may lead to sudden death or severe deterioration in quality of life. Although the prognosis of PRNN was poor, endoscopic debridement with local vascularized flap recently showed favorable outcomes, and many centers are using this technique with a nasoseptal flap. However, if the flap fails or does not fully cover necrotized tissues, necrosis inevitably reoccurs. In this situation, free flap transfer with a facial incision using a transmaxillary approach is used, but some drawbacks exist. In this report, we propose a new resurfacing technique for recurrent PRNN using a transoral-cervical free flap tunneling approach into the nasopharynx without a facial incision after endoscopic debridement.
Propuesta de arquitectura empresarial para la mejora del proceso de planta concentradora de una minera subterránea en el Perú
Authors:   , Diaz Estrella Lizbeth Grettel , Montaño Avalos Gino Milton
Published: July 2021

La elaboración manual de reportes y el registro no centralizado de información dentro de una empresa conlleva a la perdida de información valiosa que puede generar una ventaja competitiva importante. Del mismo modo, la automatización de procesos empresariales proporciona beneficios dentro de los cuales se encuentran: mayor productividad, reducción de tiempo, optimización de costos, generación de una base de conocimientos y sobre todo la obtención de la información en tiempo real. Contar con la información en tiempo real en los procesos claves permite la toma de decisiones de modo más eficiente generando así un mayor valor para la empresa. En este contexto, el presente trabajo tiene como objetivo elaborar una arquitectura empresarial que permita la mejora del proceso de “Planta Concentradora” basado en la automatización tecnológica de actividades claves del proceso. Como resultado de la automatización se podrá contar con una base de conocimiento desde la cual se podrá obtener información para dar solución a las incidencias del proceso, se reducirá el tiempo de elaboración en los reportes y se podrá consultar el resultado de cada subproceso en tiempo real.
Propuesta de Solución Tecnológica para la Automatización del Proceso de Gestión Docente de una ONG
Authors:   , Reynoso Cayo Yuly Gicela , Rosas Diaz Enrique
Published: July 2021

El presente proyecto de tesis tiene como objetivo diseñar una propuesta de solución tecnológica que permita automatizar el proceso de Gestión Docente de una ONG1 dedicada a formar jóvenes de escasos recursos para que puedan insertarse en el mundo laboral formal. La propuesta está enfocada en mejorar la eficiencia del proceso que conlleva a lograr una mejor toma de decisiones del área pedagógica, cuyos resultados están alineados a los objetivos estratégicos de la organización. En el primer capítulo del documento se elabora una definición del proyecto, donde se expone información relevante de la organización objeto de estudio. Además, se describe el problema encontrado en la organización y se definen los objetivos del proyecto. En el segundo capítulo, se fundamenta el cumplimiento de los Student Outcomes. En el tercer capítulo, se definen los fundamentos teóricos que respaldan el desarrollo del proyecto. En el cuarto capítulo, se presenta el desarrollo del proyecto, donde primero se realiza el análisis del negocio con el apoyo del framework Zachman2, luego se describe la situación actual del proceso de Gestión Docente y el modelado AS IS del mismo y, como resultado de este análisis, se desarrolla la propuesta de solución. Para ello, se describe de forma detallada las características del sistema y sus beneficios, luego se muestra el modelado del proceso TO BE. Seguidamente, se define la lista de requerimientos y los casos de uso de sistema. Asimismo, se muestra el diseño de la arquitectura que soportará la estructura del sistema, basado en la selección de drivers arquitectónicos, conceptos de diseño, estilos arquitecturales y tácticas. Al final del capítulo se describen las especificaciones de casos de uso del sistema y se muestra los prototipos de las pantallas elaboradas para cada caso de uso. Finalmente, en el quinto capítulo, se desarrolla la gestión del proyecto bajo una metodología predictiva, donde se han planificado las áreas de conocimiento que nos sugiere la guía PMBOK.
Efectos del Congestionamiento causado por la demora en la disposición de mercancías en Abandono y/o Inmovilizadas en los Depósitos Temporales autorizados por la SUNAT en la Aduana Marítima del Callao, en el 2019
Authors:   , Barco Calle Gosver , Villanera Fano Elida Angelica
Published: July 2021

El presente trabajo de investigación busca Identificar de qué manera afecta el congestionamiento causado por la demora en la disposición de mercancías en Abandono y/o inmovilizadas a los Depósitos Temporales autorizados por la SUNAT en la Intendencia Aduana Marítima del Callao, en el 2019; para ese efecto nuestro estudio se divide en cuatro (4) capítulos, los cuales son detallados a continuación: El primer capítulo se centra en el plan de investigación, por medio del cual planteamos la situación problemática, los problemas, los objetivos principales y específicos; y la formulación de la hipótesis de trabajo de la investigación. El segundo capítulo da a conocer los antecedentes de la investigación nacionales e internacionales, el marco conceptual y el análisis del sector a investigar. El tercer capítulo se centra en la metodología de la investigación, donde detallamos el tipo, propósito, categorías, delimitaciones, diseño de la investigación y tamaño de muestra. Asimismo, en este capítulo desarrollamos las entrevistas de profundidad, las cuales serán de utilidad para el recojo de información. Finalmente, el cuarto capítulo se enfoca en el análisis y discusión de resultados de nuestra investigación para así encontrar los hallazgos y realizar tanto las conclusiones como las recomendaciones finales por medio del análisis de documentos y de la información obtenida mediante las entrevistas de profundidad desarrolladas en nuestro estudio.
Análisis de los Beneficios de la implementación del principio de Responsabilidad Extendida del Productor (REP) en los neumáticos fuera de carretera en el Perú
Authors:   , Peña Palomino Sonia Marisol , Rios Casstell Burgos Bletsy
Published: July 2021

En los últimos años los países prestan atención con el cuidado y protección del medio ambiente, por ello se dictaminan normas y leyes que incentiven el buen manejo de los residuos sólidos. En el Perú existe el Decreto Legislativo 1278 Ley de Gestión Integral de Residuos Sólidos, pero la inadecuada disposición de los neumáticos en desuso genera problemas ambientales y de salud. Más aún, no se aprovechan las materias primas de estos bienes para convertirlos en otros productos aplicando la Economía Circular, es decir priorizando la recuperación y valorización de estos productos; lo que conlleva a una reducción en la generación de residuos sólidos. La presente tesis consiste en conocer los beneficios de la implementación del principio de la responsabilidad extendida del productor (REP) en los neumáticos “fuera de carretera”. (OTR por sus siglas en inglés [off the road]). En ese sentido, en el capítulo I se presenta el contexto del problema de investigación, así como la formulación del problema y sus respectivos objetivos. El capítulo II busca contextualizar la situación global, regional y nacional sobre el principio REP en los neumáticos. En el capítulo III se aborda la metodología, los segmentos y categorías referente al tema de investigación. En el capítulo IV se desarrolla los resultados obtenidos y finalmente, en el capítulo V se recaban, interpretan y analizan las conclusiones y recomendaciones de estudio. Asimismo, se detallan las barreras y brechas de investigación.
Utiliza��ǜo de indicadores de qualidade: dificuldades e estratǸgias na voz de enfermeiros-l��deres
Authors: Pretto Bǭo Ana Cristina , Amestoy Simone Coelho , Trindade Let��cia De Lima , Moura Gisela Maria Schebella Souto de , Souza Andrieli Daiane Zdanski de
Published: July 2021

Objetivo: Conhecer as dificuldades e estratǸgias dos enfermeiros-l��deres na utiliza��ǜo dos indicadores de qualidade em ambiente hospitalar. MǸtodo: Pesquisa qualitativa, explorat��rio-descritiva, realizada em hospital filantr��pico do Sul do Brasil, na qual participaram 12 enfermeiros. Adotaram-se entrevistas semiestruturadas e grupo focal para a coleta de dados, os quais foram analisados conforme anǭlise de conteǧdo. Resultados: Os enfermeiros evidenciaram como dificuldades a subnotifica��ǜo de eventos adversos, os limites na interpreta��ǜo e aplicabilidade dos dados, falta de tempo e falta de compartilhamento das informa����es na utiliza��ǜo dos indicadores de qualidade. Jǭ como estratǸgias compartilharam a constru��ǜo e discussǜo coletiva, o envolvimento da equipe de enfermagem e saǧde, o feedback entre os profissionais e a educa��ǜo permanente. Conclusǜo: �% necessǭria a sensibiliza��ǜo dos gestores das institui����es de saǧde, para a instrumentaliza��ǜo dos enfermeiros, de maneira a desenvolver competǦncias necessǭrias para a melhor utiliza��ǜo dos indicadores de qualidade, bem como investimentos para superar as dificuldades.
Caracter��sticas dos atendimentos ��s v��timas de trauma admitidas em um pronto socorro via transporte aǸreo
Authors: Macedo Camargos de Oliveira Caio Henrique , Gomes da Silva Tha��s Regina , Oliveira Tha��s Moreira , De Carvalho Frederico Bruzzi , CorrǦa Allana Dos Reis
Published: July 2021

Objetivo: Descrever as caracter��sticas dos atendimentos ��s v��timas de trauma admitidas em um pronto socorro de grande porte, via transporte aǸreo. MǸtodo: Estudo transversal que analisou 107 prontuǭrios de v��timas de trauma admitidas via transporte aǸreo. Os dados foram submetidos �� anǭlise estat��stica descritiva. Resultados: Predominou o sexo masculino (63,3%), mediana de idade de 32 anos (IQ:23-51), v��timas de colisǜo automobil��stica (28,0%), transportadas por servi��o aǸreo pǧblico (86,0%) e n��vel de prioridade vermelho (55,7%). �_ admissǜo, 55,0% possu��am pr��tese de vias aǸreas e 57,9% tiveram lesǜo na regiǜo do crǽnio. 72,9% realizou tomografia, 60,7% recebeu tratamento cirǧrgico e 12,1% evoluiu a ��bito no pronto socorro. O tempo de interna��ǜo hospitalar teve mediana de sete dias (IQ: 1,5 -33,0), 57,0% recebeu alta domiciliar e 26,2% evoluiu a ��bito. Conclusǜo: As v��timas, maioritariamente, eram graves e demandaram atendimento imediato e especializado, incluindo propedǦuticas e terapǦuticas de alta complexidade.
Gravidade e les��es traumǭticas em v��timas de acidente de trǽnsito internadas em um hospital pǧblico
Authors: Rocha Greiciane Silva , Silva Catharie �_vila da , Crispim Let��cia Vieira
Published: July 2021

Objetivo: Identificar as principais les��es das categorias de v��timas em acidentes de trǽnsito e sua gravidade. MǸtodo: Estudo quantitativo, transversal, com 276 v��timas internadas e, a partir de dados de prontuǭrios e entrevistas, foi realizada associa��ǜo log��stica para anǭlises. Resultados: Houve maior frequǦncia do sexo masculino (78,9%), na faixa etǭria de 21 a 39 anos (50,3%) e motociclistas (74,6%). A lesǜo mais comum: fratura fechada (44,5%) em membros inferiores (41,9%). A ocorrǦncia de lesǜo cerebral, lesǜo torǭcica e idade aumentam a chance de trauma grave, enquanto o estado civil casado diminui a chance, independente do sexo. Conclusǜo: Assim, vale destacar que os dados apresentados sǜo fundamentais, para o processo de enfermagem no trauma, visto que as les��es de membros inferiores com fraturas sǜo destaques na categoria de motociclistas e que juntamente com as les��es cerebrais e torǭcicas incrementam a mortalidade nessas ocorrǦncias.
Desejos ante a inexorǭvel finitude: antes de morrer eu quero...
Authors: Andrade Joǜo Vitor , Lins Ana Luiza Rodrigues , Mendon��a Erica Toledo de
Published: July 2021

Objetivo: Compreender o que anseiam estudantes e profissionais de saǧde ante a inexorǭvel finitude. MǸtodo: Estudo fenomenol��gico, fundamentado na fenomenologia existencial, realizado com 50 estudantes e profissionais da saǧde. Resultados: Os anseios relacionavam-se ��: �_orealiza��ǜo pessoal�__ (me formar, ter um bom trabalho); �_oconstitui��ǜo de fam��lia�__ (me casar, ter filhos), �_oascensǜo social�__ (melhorar minha condi��ǜo financeira); �_orealiza��ǜo de viagens nacionais e internacionais�__ (conhecer todo o Brasil, ir para a Europa); �_oaquisi��ǜo de animais de estima��ǜo�__ (ter um cachorro, adquirir gatos), ao �_oconsumo de alimentos�__ (comer chocolate, devorar uma boa pizza). Conclusǜo: O ser-a��-indiv��duo-ante-a-inexorǭvel-finitude revela-se com maior concentra��ǜo de anseios nas dimens��es sociais e de autorrealiza��ǜo nas Necessidades Humanas, traduzidos na busca de felicidade, liberdade e paz. A abordagem do processo de finitude deve ser fortalecida na forma��ǜo em saǧde, por meio da promo��ǜo de espa��os que favore��am o diǭlogo e o autoconhecimento.
Developers’ Data Protection in the Open-Source Application with the Copyleft License
Authors: Serfiyani Citi Rahmati , Yustisia Serfiyani Cita , Hariyani Iswi , Tharifah Arsari Devina
Published: July 2021

Copyright protection of digital products in an open-source system has led to the emergence of copyleft against copyright. Copyleft licenses in open-source serve to impose limits on creations to protect creators' moral rights. At the same time, personal data protection is one part of personal rights amidst the advent of information technology. The development of copyleft products and licenses that usually take place online can potentially lead to violations that harm application developers’ personal data. This paper aimed to characterize copyleft as an antithesis of copyright and analyze legal protection on the open-source application developers' personal data. Using legal research, this paper showed that open-source licenses could consist of two categories. First, non-copyleft licenses in the form of permissive licenses, included in the software under it and are subject to copyright. Second, the copyleft license, which required licenses to modify and distribute copyleft products. This open-source license adopted a form of a standard contract and personal data protection in copyleft products through open-source sites were using a preventive and repressive way. This paper recommended a copyleft-based legal protection mechanism and creators' data by considering the comparative aspects of the copyleft and copyright concepts' characteristics to respect moral rights.

KEYWORDS: Personal Data Protection, Indonesia’s Copyright Law, Copyleft License.
Muckle-Wells syndrome (a clinical case)
Authors:   Irkutsk State Medical Academy of Continuing Education, Tolstikova T.V. , Bregel L.V. ,   Irkutsk State Medical Academy of Continuing Education, Matyunova A.E. ,   Irkutsk State Medical Academy of Continuing Education, Shinkareva V.M. ,   Irkutsk State Regional Children’s Clinical Hospital, Knyazeva T.S. ,   Scientific Center for Family Health and Human Reproduction, Gvak G.V. ,   Irkutsk State Medical Academy of Continuing Education
Published: July 2021

A clinical case of Muckle-Wells syndrome in a 3-years old child is presented. Muckle-Wells syndrome is among the group of human autoinflammatory diseases (cryopyrin-associated periodic syndromes) – rare genetic diseases characterised by systemic inflammation in absence of other revealed autoimmune and infectious reasons. The disease is characterised by the combination of fever, skin rash and other symptoms accompanied by development of potentially disabling or life-threatening complications. The clinical case presented illustrates the course as well the difficulties in diagnosis and treatment of Muckle-Wells syndrome.
The history of coronary surgery development
Authors:   Federal Center for Cardiovascular Surgery, Muradov A.G. , Efendiev V.U. ,   Federal Center for Cardiovascular Surgery, Andin A.V. ,   Federal Center for Cardiovascular Surgery, Drobot D.B. ,   Federal Center for Cardiovascular Surgery, Demidov D.P. ,   Federal Center for Cardiovascular Surgery, Sakovich V.A. ,   Federal Center for Cardiovascular Surgery
Published: July 2021

The leading place among cardiovascular diseases in the world – 50% – belongs to the ischaemic heart disease. Coronary bypass grafting is the golden standard for treatment of patients with multivessel ischaemic heart disease. The modern level of coronary surgery makes it possible to perform safe and efficacious direct revascularisation with hospital lethality not exceeding 1-3%. This article presents a review of literature devoted to the history of coronary surgery development including analysis of relevant sources dated 2010-2020 published in PubMed and Google Scholar databases: from first experimental procedures in the beginning of the 20th century and indirect myocardial revascularisation methods to direct bypass grafting of the impaired heart vessels actively developed since early 1960s. The article describes types of grafts applied with description of advantages and disadvantages of each one as well as contemporary methods and conditions for coronary bypass grafting and further prospects in development of ischaemic heart disease surgery.
Study of adherence of pharmaceutical workers and population to immunoprophylaxis of coronaviral infection
Authors: Nefedov I. Yu. , Nefedova I. Yu. , Valeeva D. T.
Published: July 2021

The results of this study indicate a lack of adherence to immunoprophylaxis of coronavirus infection both among the surveyed pharmaceutical workers, who are both senior students of the pharmaceutical faculty, and the population, and the need for educational, informational and educational work among them. The topic of immunization of coronavirus infection and other infectious diseases can be one of the topical topics in advanced training courses for pharmacists and pharmacists. In turn, the information and educational work of the pharmacist among the population, carried out in accordance with the labor functions of professional standards, can help improve people's knowledge about the device and mechanisms of action of vaccines against coronavirus. Comprehensive and understandable informing the population about vaccines, from scientific, medical, pharmaceutical, ethical, religious and other positions, can help to overcome internal anti-vaccination attitudes in people and form a commitment to immunoprophylaxis of coronavirus infection and other infectious diseases. In general, this will help people make an informed, independent and free decision about immunization.
PENGARUH JENIS PELARUT DAN METODE EKSTRAKSI TERHADAP AKTIVITAS ANTIBAKTERI DAN PENGHAMBATAN RADIKAL BEBAS EKSTRAK KULIT KAYU BANGKAL (Nauclea subdita)
Authors: Rahmi Nazarni , Salim Rais , Miyono Miyono , Rizki M Ikhwan
Published: July 2021

Kulit kayu bangkal merupakan salah satu bahan alami yang banyak dimanfaatkan oleh penduduk lokal Kalimantan Selatan untuk pengobatan dan perawatan kecantikan. Masih terbatas penelitian yang mengeksplorasi ekstrak kulit kayu bangkal dalam hal penentuan proses ekstraksi yang optimal, pemilihan pelarut, kandungan senyawa kimia serta aktivitas biologis yang dimiliki oleh ekstrak bangkal. Penelitian ini bertujuan untuk menentukan pengaruh metode ekstraksi dan jenis pelarut terhadap kandungan senyawa aktif berikut aktivitas antibakteri dan aktivitas penghambatan radikal bebas dari ekstrak kulit kayu bangkal. Kayu bangkal diekstraksi dengan metode maserasi, perkolasi dan soxhletasi dengan berbagai pelarut yaitu akuades, etanol 96, etanol 70% dan etil asetat. Total senyawa fenolik ditentukan dengan metode Folin ciocalteu, total flavonoid dengan AlCl3, dan total tanin dengan vanilin. Pengujian aktivitas penghambatan radikal bebas menggunakan metode DPPH dan antibakteri dengan metode difusi agar. Hasil pengujian menunjukkan metode sokhletasi dengan pelarut etanol 96% mempunyai kandungan total fenolik yang tertinggi sebesar 81,12±1,66 mg/gr GAE. Total flavonoid tertinggi terdapat pada metode perkolasi dengan pelarut etil asetat yaitu 24,24± 0,057 mg/gr QE dan total tanin terbaik pada metode perkolasi menggunakan pelarut etanol 96% sebesar 36,92±,81 mg/gr CE. Ekstrak etanol 70% pada ketiga metode ekstraksi menunjukkan penghambatan radikal DPPH yang sama besar diatas 80%. Aktivitas antibakteri pada ekstrak menunjukkan semua perlakuan metode dan jenis pelarut mempunyai daya hambat terhadap P. acne dengan zona hambat yang bervariasi sementara hanya ekstrak etil asetat dan air yang mampu menghambat P. acne dan S. aureus. Metode ekstraksi dan polaritas pelarut memegang peran penting dalan menentukan metode yang efisien dalam mengekstraksi fitokimia dan aktivitas biologis pada bangkal.
Genotype Pattern Mining for Pairs of Interacting Variants Underlying Digenic Traits
Authors: Okazaki Atsuko , Horpaopan Sukanya , Zhang Qingrun , Randesi Matthew , Ott Jurg
Published: July 2021

Some genetic diseases (“digenic traits”) are due to the interaction between two DNA variants, which presumably reflects biochemical interactions. For example, certain forms of Retinitis Pigmentosa, a type of blindness, occur in the presence of two mutant variants, one each in the ROM1 and RDS genes, while occurrence of only one such variant results in a normal phenotype. Detecting variant pairs underlying digenic traits by standard genetic methods is difficult and is downright impossible when individual variants alone have minimal effects. Frequent Pattern Mining (FPM) methods are known to detect patterns of items. We make use of FPM approaches to find pairs of genotypes (from different variants) that can discriminate between cases and controls. Our method is based on genotype patterns of length two, and permutation testing allows assigning p-values to genotype patterns, where the null hypothesis refers to equal pattern frequencies in cases and controls. We compare different interaction search approaches and their properties on the basis of published datasets. Our implementation of FPM to case-control studies is freely available.
Sociodemographic characteristics of vaccine-refusing families and reasons for refusal
Authors:   Far Eastern State Medical University, Khabarovsk, Russian Federation, Senkevich O.A. , Plotonenko Z.A. ,   Far Eastern State Medical University, Khabarovsk, Russian Federation, Molochniy V.P. ,   Far Eastern State Medical University, Khabarovsk, Russian Federation, Kaplieva O.V. ,   Far Eastern State Medical University, Khabarovsk, Russian Federation
Published: July 2021

Vaccination is a reliable way to prevent many infectious diseases. Reduced vaccination coverage along with increased migration, high population density, and high risk of epidemic outbreaks makes the issue of vaccine commitment among parents and the problem of vaccine refusal highly relevant. Objective. To analyze sociodemographic characteristics of vaccine-refusing families and reasons underlying their refusal. Patients and methods. We have conducted a blind, consecutive, cross-sectional, cohort study that included 2 groups of respondents: Group 1 included 80 mothers of newborns followed-up at the Perinatal Center, whereas Group 2 comprised 135 mothers of children aged 2–3 years followed-up at the Children's Polyclinic No 2, Children's City Hospital No 9 of Khabarovsk. Data collection was performed between January and September 2018 and included the survey of mothers. The questionnaire was aimed to assess sociodemographic characteristics of the respondents and reasons for refusing vaccination. Results. We have analyzed sociodemographic characteristics of vaccine-refusing families and identified the differences in the social status of mothers of newborns and children aged 2–3 years. In the maternity hospital, young mothers (74.2%) who are officially married (57.5%) with 2 or more children, with secondary or specialized secondary education (58%) were most likely to refuse vaccination. Young mothers of the first child with higher education (65%) (48.5% with higher medical education), with an average income (60%) most frequently refused previous vaccinations of children aged 2–3 ages. In more than half of the cases, there was one child in the family (65.5%); these were primarily two-parent, socially advantaged families. We observed a prior role of a pediatrician as a source of information about vaccination of children and a high level of trust in public health institutions in terms of vaccination. Conclusion. Our findings indicate that the attitude to vaccines is generally positive. However, some parents, whose children may be a reserve for increasing the number of timely vaccinated children, realize the importance of vaccination, but due to some objective reasons (such as medical contraindications) or without substantial reasons postpone it indefinitely. Key words: vaccination, children, refusal, adherence
Mono- and mixed respiratory tract infections in children: relevance of the problem during the COVID-19 pandemics
Authors:   Central Research Institute of Epidemiology, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Moscow, Russian Federation, Nikolaeva S.V. , Usenko D.V. ,   Central Research Institute of Epidemiology, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Moscow, Russian Federation, Shabalina S.V. ,   Central Research Institute of Epidemiology, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Moscow, Russian Federation, Khlypovka Yu.N. ,   Central Research Institute of Epidemiology, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Moscow, Russian Federation,   Central Clinical Hospital with Polyclinic of the Administration of the President of the Russian Federation, Moscow, Russian Federation, Gorelov A.V. ,   Central Research Institute of Epidemiology, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Moscow, Russian Federation,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation
Published: July 2021

Acute respiratory infections are one of the most common infections in children worldwide. The implementation of novel highly accurate diagnostic methods demonstrated that a significant proportion of respiratory tract infections are caused by more than one pathogen (virus plus virus or virus plus bacterium). Most frequently, mixed infections are observed in young children, which, in addition to non-specificity of most clinical manifestations, necessitates pathogen identification in order to prevent inadequate use of antibiotics. Key words: respiratory infections, children, respiratory pathogen
Artemether and imatinib combination therapy against malaria infection
Authors:   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Kondrashin A.V. , Stepanova E.V. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Morozova L.F. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Sergiev V.P. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Maksimova M.S. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Turbabina N.A. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Malysheva N.S. ,   Kursk State University, Kursk, Russian Federation, Solovyeva E.A. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Kurashkina I.V. ,   Ministry of Industry and Trade of the Russian Federation (Minpromtorg), Moscow, Russian Federation, Dovgalev A.S. ,   Russian Medical Academy of Continuous Professional Education, Moscow, Russian Federation, Morozov E.N. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation,   Russian Medical Academy of Continuous Professional Education, Moscow, Russian Federation
Published: July 2021

Artemisinin-based combination therapy (ACT) is recommended by the World Health Organization (WHO) as the first and second line of treatment for uncomplicated malaria caused by P. falciparum, as well as for chloroquine-resistant P. vivax malaria. Despite the large number of antimalarial drugs, there is no any ideal drug, since each individual combination of drugs or monotherapy have their own limitations, ranging from their triple (activity) in relation to certain forms of the development of Plasmodium in the human body, side effects, toxicity and resistance. During the course of the study carried out, the most promising compound-candidate was selected – imatinib, which is currently used as targeted therapy for a number of oncological diseases. The objective of this work is to evaluate the efficacy of the combined use of imatinib and artemether in vivo studies on the human malarial model – the rodent malaria parasites Plasmodium berghei. Dut to the optimally selected treatment scheme, it was possible to reduce the dosage of imatinib twice – to 0,25 mg/kg, and that of artemether three times – to 33 mg/kg. The use of this scheme made it possible to considerably reduce the toxic effect of these drugs due to the potentiation of antimalarial effect. Key words: malaria, drug resistance, telomerase inhibitors, imatinib, chemotherapy of malaria
Role of antioxidant therapy in patients with moderate and severe COVID-19
Authors:   Peoples' Friendship University of Russia (RUDN), Moscow, Russian Federation, Shavarova E.K. ,   V.V.Vinogradov City Clinical Hospital, Moscow Healthcare Department, Moscow, Russian Federation, Cazakhmedov E.R. ,   Peoples' Friendship University of Russia (RUDN), Moscow, Russian Federation, Alekseeva M.V. ,   Peoples' Friendship University of Russia (RUDN), Moscow, Russian Federation, Ezhova L.G. ,   V.V.Vinogradov City Clinical Hospital, Moscow Healthcare Department, Moscow, Russian Federation, Kobalava Zh.D. ,   Peoples' Friendship University of Russia (RUDN), Moscow, Russian Federation
Published: July 2021

The coronavirus disease COVID-19 is characterized by high mortality and the lack of effective etiotropic therapy. Activation of oxidative stress may be one of the links in the pathogenesis of organ damage of this infection. Objective. To assess the ability of Mexidol® to influence the rate of clinical improvement in pneumonia caused by the SARSCoV-2 virus in hospitalized patients with the novel coronavirus disease COVID-19 and concomitant discirculatory encephalopathy. 62 patients over the age of 18 years with confirmed new coronavirus disease COVID-19 according to computed tomography (CT) of the lungs (stages CT1, CT2, CT3) and PCR of a swab from the nasopharynx and oropharynx for SARS-CoV-2 virus RNA were included. After randomization patients of group 1 received an infusion of Mexidol® at a dose of 1000 mg/day, patients of group 2 – an infusion of isotonic sodium chloride solution for 7 days. Compared with the control group, the patients receiving Mexidol® therapy showed a significantly more pronounced decrease in body temperature, a tendency towards a decrease in the severity of shortness of breath. In the Mexidol® group, the concentration of superoxidedismutase did not change, while in the control group there was a tendency to its decrease, C-reactive protein decreased 2.2 times more than in the control group (p = 0.09). There was a tendency for a more rapid decrease in ferritin in the active intervention group. Mexidol® therapy can have a positive effect on the clinical manifestations and severity of laboratory-inflammatory syndrome in patients with the new coronavirus disease COVID-19. Key words: coronavirus disease COVID-19, oxidative stress, Mexidol
Ascertainment of Patient Suicides by Veterans Affairs Facilities and Associations With Veteran, Clinical, and Suicide Characteristics
Authors: Palframan Kristen M. , Szymanski Benjamin R. , McCarthy John F.
Published: July 2021

Objectives. To evaluate the sensitivity of health care facility documentation of suicide deaths among US veterans with recent Veterans Health Administration (VHA) care and assess variation in identification by veteran, clinical, and suicide death characteristics.

Methods. Cross-sectional analyses included 11 148 veterans who died by suicide in 2013 to 2017, per National Death Index death certificate information, with VHA encounters in the year of death or the previous year. Facility suicide ascertainment was assessed per site reports in the VHA Suicide Prevention Applications Network. Bivariate and multivariable analyses assessed ascertainment by decedent demographic, clinical, utilization, and method of suicide characteristics.

Results. Site reports identified 3667 suicide decedents (32.9%). Veteran suicide decedents identified by facilities were more likely to be younger and with clinical risk factors and more recent VHA encounters. Suicide deaths involving poisoning were less likely to be identified than deaths involving other methods.

Conclusions. VHA facility ascertainment of suicide deaths among recent patients was neither comprehensive nor representative. Findings will inform efforts to enhance facility suicide surveillance and veteran suicide prevention.
Development of learning videos of atomic theory concepts of Tialo language
Authors: Farhana Filza , Saehana Sahrul , Halim Lilia
Published: July 2021

The purpose of this research is to produce a video learning content on atomic theory. This research uses the design and development design that employs the ADDIE model. The research instrument used was a questionnaire with a four-likert scale admistered on content experts, linguists, media experts, teachers and 10 students of MA AL-KHAIRAAT Tomini. The validity of the content, language and media aspects was said to be good with scores of 3.25; 3.33 and 3.28 respectively. Meanwhile, the scores obtained from teachers and students of class XI IPA were 3.87 and 3.51, both of which were in the "Strongly Agree" category. The results showed that the atomic theory learning video in the Tialo language was suitable for use in learning activities and could increase the concentration level of students. The theoretical implications of this research, namely the instructional video can increase learning motivation in students and the practical implication is that the instructional video is used as resources for teachers and prospective teachers to be used in the learning process.
The implementation of RADEC learning model in thematic learning to increase the concept understanding of electrical phenomenon
Authors: Rohmawatiningsih Wati , Rachman Indriyani , Yayoi Kodama
Published: July 2021

This research is motivated by the large number of elementary school classrooms that do not offer quality science experiences to students so that it has an impact on students' low understanding of the science concept. The RADEC (Read-Answer-Discuss-Explain And Create) learning model seems suitable for increasing students' understanding of science concepts. This learning model has scientific stages that encourage the cons-truction of students' knowledge. This study aims to analyze the increased understanding of the concept of electrical phenomena through the application of the RADEC learning model. The study involved twenty-eight grade 5 students in the 2019-2020 academic year. Quasi-experimental method with one-group pretest-postest design was used in this study. To find out the understanding of students' concepts about electrical phenomena, tests were carried out before and after the implementation. This study uses descriptive analysis to analyze data collected before and after implementation. From the results of the analysis, it is known that students' understanding of the concept of electrical phenomena after the implementation of the RADEC learning model is higher than before. Thus, it can be concluded that the application of the RADEC learning model can improve students' conceptual understanding of electrical phenomena.
The Evolutionary Equilibrium of Block Withholding Attack
Authors: Cheng Yukun , Xu Zhiqi , Yao Shuangliang
Published: July 2021

Bitcoin is the most famous and the most used cryptocurrency in the world, such that it has received extreme popularity in recent years. However the Bitcoin system is accompanied by different attacks, including the block withholding (BWH) attack. When a miner plays the BWH attack, it will withhold all the blocks newly discovered in the attack pool, damaging the honest miners’ right to obtain the fair reward. In this paper, we consider a setting in which two miners may honestly mine or perform the BWH attack in a mining pool. Different strategy profiles will bring different payoffs, in addition influence the selection of the strategies. Therefore, we establish an evolutionary game model to study the behavior tendency of the miners and the evolutionary stable strategies under different conditions, by formulating the replicator dynamic equations. Through numerical simulations, we further verify the theoretical results on evolutionary stable solutions and discuss the impact of the factors on miners’ strategic choice. Based on these simulation results, we also make some recommendations for the manager and the miners to mitigate the BWH attack and to promote the cooperation between miners in a mining pool.