bluuebunny/crossref_metadata_2025 huggingface dataset:
Cefiderocol
Authors: Soriano María Cruz , Montufar Jessie , Blandino-Ortiz Aaron
Published: April 2022

Cefiderocol is a new siderophore cephalosporin with potent in vitro activity against gram-negative bacilli including Enterobacterales that produce all kinds of carbapenemases and non-fermenting Gram-negative with difficult-to-treat resistance. As a β-lactam, its efficacy is optimized in extended-perfusion and requires dose adjustment in renal dysfunction and hyperclearance. Its efficacy has been validated in three clinical trials, one of them in the treatment of hospital-acquired pneumonia and ventilator-associated pneumonia. The clinical trial aimed at difficult-to-treat gram-negatives achieved the clinical and microbiological target, but the increase in mortality observed in the cefiderocol arm makes it necessary to demonstrate efficacy in real clinical practice. Cefiderocol is a good option among the new β-lactams for the treatment of pneumonia caused by Gram-negative bacilli carbapenem-resistant.
Ceftolozane-tazobactam in nosocomial pneumonia
Authors: Candel Francisco Javier , González del Castillo Juan , Julián Jiménez Agustín , Matesanz Mayra
Published: April 2022

Ceftolozane is a potent antimicrobial against Pseudomonas aeruginosa, including carbapenem-resistant and multidrug-resistant strains, and is also active against Enterobacteriaceae. It MIC (minimal inhibitory concentration) and MPC (mutant preventive concentration) are close together, allowing to avoid the mutant selection window specifically in the treatment of Pseudomonas aeruginosa infection. The molecule is time-dependent and stable when reconstituted at room temperature, facilitating safe and effective dosage optimization in frail and critically ill patients. It has been shown to be non-inferior to meropenem in the treatment of nosocomial infection in the ASPECT-NP study but superior in post-hoc studies in the subgroup of patients with ventilator-associated pneumonia, without the emergence of resistance during treatment. It is FDA approved at a dose of 3 g every 8 hours in the treatment of nosocomial pneumonia (HABP/VABP) in adults.
Respiratory infections in Coronavirus disease 2019
Authors: del Pozo Jose L.
Published: April 2022

In the last two years, the capacity of our hospitals has clearly been overwhelmed due to the COVID-19 pandemic The patient who comes to the hospital with a respiratory coinfection does not have the same characteristics as the patient who suffers a superinfection while hospitalized. The number of secondary infections increase proportionally to the severity of the patient’s disease. Besides, pathogens that cause a coinfection are clearly differentiated from the pathogens that cause a superinfection. However, in patients subjected to airway manipulation, superinfections by distinct pathogens can occur. Seventy five percent of patients admitted worldwide with COVID-19 (especially during the first two waves of the pandemic) received some form of antibiotic treatment during admission. In this context, it is essential to develop and implement algorithms that allow us to define the predictors in each individual case for the development of a superinfection.
Respiratory consequences after COVID-19: outcome and treatment
Authors: Molina-Molina María , Hernández-Argudo Marta
Published: April 2022

The SARS-CoV-2 (COVID-19) pandemic represents the infection with the highest lethality, but also the one that has caused the most sequelae and multi-organ consequences, especially respiratory, in the last century. Several actions have been required in the field of respiratory and intensive care medicine to reduce mortality and chronicity. The consequences of COVID-19 are multiple and encompass different physical, emotional, organizing, and economic aspects, which will require a multidisciplinary, transversal, and collaborative approach. This review includes the observations and results of published retrospective and prospective studies on post-COVID19 respiratory sequelae, especially after severe pneumonia with associated adult respiratory distress syndrome (ARDS).
Diagnostic and therapeutic approach to fungal pneumonia in the critically ill patient
Authors: Fortún Jesús
Published: April 2022

Aspergillus spp. is the fungus most frequently producing ventilator-associated pneumonia (VAP), constituting 8% of them. This risk is significantly increased in onco-hematological patients: solid organ transplant recipients, chronic obstructive pulmonary disease (COPD), corticotherapy, cirrhosis, solid cancer, or viral pneumonias. The European Organization for Research and Treatment of Cancer Mycoses (EORT/MSG criteria) developed for onco-hematological patients with angioinvasive forms of aspergillosis have important limitations for broncho-pulmonary forms, such as aspergillosis cases in the ICU. In recent years, new diagnostic criteria were developed to have a greater role in broncho-alveolar lavage, especially GM and lateral flow assay (LFA). Voriconazole and isavuconazole are the first treatment option. However, drug-drug interaction, level requirements, toxicity, and QT-interval modification are limitations that may favor isavuconazole or liposomal amphotercin B in the ICU.
PEKERJAAN DAN KEGANASAN RUMAH TANGGA: SATU KAJIAN KUANTITATIF TERHADAP PASANGAN YANG BERKAHWIN DI MALAYSIA
Authors: Ayob Nuruaslizawati , Abdul Rauf Siti Hajar , Hadjiri Rumaina , S Nurunsa'adah
Published: April 2022

Abstract: Married is a love relationship between a man and a woman that based on a bond. However, there are various reports of domestic violence cases reported to the authorities. A study on domestic violence involving spouse's job status was conducted by looking at four forms of violence namely physical, emotional, economic, and sexual violence. This study was conducted using quantitative design using survey method. Data were collected by distributing questionnaires to 390 Muslim respondents who are married or have been married and live in Terengganu and Kelantan.  Data were analyses through Statistical Package for the Social Science (SPSS) version 22 and processed using inferential analysis (ANOVA). The findings found that the employment status of the respondents had a significant relationship on the forms of violence. This situation has gave an impression that it is important for all parties to evaluate the situation and develop interventions to reduce cases of domestic violence. 

Keywords: Domestic violence; Women; Patriarchy; Job status; Power and control

 

Abstrak: Perkahwinan merupakan hubungan cinta yang terjalin antara lelaki dan perempuan yang didasari dengan sebuah ikatan. Namun begitu, saban hari terdapat pelbagai laporan mengenai kes keganasan rumah tangga dilaporkan kepada pihak berkuasa. Satu kajian mengenai keganasan rumah tangga melibatkan pekerjaan pasangan telah dijalankan dengan melihat empat bentuk keganasan iaitu keganasan fizikal, emosi, ekonomi dan seksual. Kajian ini menggunakan reka bentuk kuantitatif melalui kaedah tinjauan. Data dikumpul dengan mengedarkan soal selidik kepada 390 responden beragama islam yang berkahwin atau pernah berkahwin dan tinggal Negeri Terengganu dan Kelantan. Data dalam kajian ini dianalisis melalui perisian  Statistical Package for the Social Science (SPSS) versi 22 dan diolah menggunakan analisis berbentuk inferensi (ANOVA). Hasil dapatan mendapati bahawa status pekerjaan responden mempunyai perbezaan yang signifikan terhadap bentuk keganasan. Keadaan ini telah memberi satu gambaran bahawa adalah penting bagi semua pihak menilai situasi ini dan mengembangkan intervensi bagi mengurangkan kes keganasan rumah tangga.

Kata kunci: Keganasan rumah tangga; Wanita; Patriarki; Status pekerjaan; Kuasa dan kawalan
MEMPERKASAKAN KEMAHIRAN BERFIKIR ARAS TINGGI (KBAT) DALAM MENGUNGKAI MAKNA DI SEBALIK BAHAN SENI BAHASA: SATU PENDEKATAN SEMANTIK INKUISITIF
Authors: Bujang George Romiko , Subet Mary Fatimah
Published: April 2022

Abstract: Rhymes is a language’s art material that should be learned in Malay Language Education especially at the primary school education level. However, a number of students are facing the difficulty of discovering the implicit meaning contained in the language's art material. Thus, this study was carried out to describe either the Inquisitive Semantic (IS) approach introduced by Nor Hashimah Jalaluddin (2014) can stimulate the cognitive of students to unravel the implicit meaning of the rhymes. This qualitative study used a text analysis and observation 7 respondents consisting of Year Five students.  The findings showed that pupils able to carry out an implicit meaning through systematic and multidisciplinary methods. The using of Relevance Theory in the second stage of resonance semantic analysis makes learning Malay education more interesting and meaningful as well as providing better quality learning outcomes. Inquisitive Semantics approach is expected to help students empower High Order Thinking Skills (HOTS) in the teaching and learning language arts’ process.

Keywords: Language arts; Resonance Semantic;, Inquisitive Semantics; Relevance Theory; HOTS.

  

Abstrak: Sajak merupakan bahan seni bahasa yang harus dipelajari dalam Pendidikan Bahasa Melayu lebih-lebih lagi di peringkat pendidikan rendah. Walau bagaimanapun, masih terdapat sebilangan pelajar menghadapi kesukaran untuk mencungkil makna tersirat yang terkandung di dalam bahan seni bahasa itu. Justeru, kajian ini dijalankan untuk menyingkap sejauh mana pendekatan Semantik Inkuisitif (SI) yang diperkenalkan oleh Nor Hashimah Jalaluddin (2014) dapat merangsang kognitif murid mengungkai makna tersirat di sebalik sajak. Kajian kualitatif ini menggunakan kaedah analisis teks bahan seni bahasa dan pemerhatian terhadap 7 orang responden yang terdiri daripada pelajar Tahun Lima. Hasil kajian mendapati pelajar berupaya mencungkil makna tersirat melalui kaedah pengesanan makna yang bersistematik dan multidisiplin. Penggunaan Teori Relevans dalam peringkat kedua analisis semantik resonans menjadikan pembelajaran pendidikan Bahasa Melayu lebih menarik dan bermakna serta memberikan hasil pembelajaran yang lebih berkualiti. Pendekatan SI ini diharap akan menjadi satu lagi pendekatan yang utama untuk membantu pelajar memperkasakan Kemahiran Berfikir Aras Tinggi (KBAT) dalam proses pengajaran dan pembelajaran seni bahasa.

Kata kunci: Seni bahasa; Semantik Resonans; Semantik Inkuisitif; Teori Relevans; KBAT
Review on Cloud Security and Challenges on Higher Education
Authors: Khalid Muhamad Irwan Ihfan , Zolkipli Mohamad Fadli
Published: April 2022

Many new developments are often plagued with security concerns. Although emerging innovations have all the potential to change systems and people's lives, security issues hinder them adoption and usage. The transformations of data management brought by cloud technologies have helped both individuals and companies. While the cloud allows data storage, connectivity, and recovery stability, it is not immune to the security threats that other new technologies pose. Concerns have been presented over the protection and privacy of cloud users' data. Data leakage, data manipulation, condemnation, a Lack of Services assault, impersonating personalities, also unauthorised access to data are all examples of activities which can appear while data is outsourced to a cloud. Individuals and organisations will orchestrate these attacks, which will jeopardise the reliability and security of cloud networks. The vast majority of colleges and universities are digitising their records, which are then stored in the cloud and handled by a third party. Despite the sacred importance of educational information, the study explores the impact of cloud security problems on schooling. According to the findings, security is crucial for the secure migration and application of cloud technology in the educational sector. It also shows that the growing security threats associated with cloud technology can prevent many education institutions from using cloud services.

 

Keywords: Cloud technology, Cloud Security, Educational, Information leakage, Privacy
Acute Urinary Retention – It Is Not about the Bladder
Authors: Shalihin Mohd Shaiful Ehsan , Yatim Yusnita , Khamis @ Roslee Nurhayaty
Published: April 2022

Chronic cyclical abdominal pain in an adolescent female is indeed a rare occasion. Nevertheless, concomitant presence of acute urinary retention in the background history delayed menarche will give clues towards possibility of imperforate hymen (IH). Nevertheless, adequate physical examination, especially abdominal and gynaecological assessment in the adolescent female is indeed important in making the conclusion. We shared a case of a 12-year-old girl who came to us with recurrent lower abdominal pain for three months associated with inability to pass urine on the day of presentation. Perineum inspection showed bulging hymen with inability to catheterize the urethral opening. Bedside ultrasound was performed and revealed a fluid filled lesion in her vagina showing features of hematocolpos. A diagnosis of imperforate hymen was made clinically, and she was referred urgently to the gynaecology team for surgical intervention. Hymenotomy was done and she was saved from further morbidity. This case highlights the importance of identifying gynaecological causes in a female patient with acute urinary retention especially if the patient had prior episodes of recurrent cyclical symptoms that may be highly associated with imperforate hymen.  

Keywords: Hematocolpos, Bladder, Acute Urinary Retention
Features of heritable TP53-related cancer syndrome
Authors: Stepanov Ilya , Vasilyeva Elena , Sokolenko Anna , Imyanitov Evgeny
Published: April 2022

Heritable TP53-related cancer syndrome (abbreviated as hTP53rc), which was previously called «Li-Fraumeni syndrome», is a heterogeneous group of tumors. It is characterized by the occurrence of a hereditary mutation in the TP53 gene.
In the last decade, the concept of hTP53rc has changed due to the accumulation of information about the disease. For example, the criteria for diagnosis and screening, as well as treatment approaches, have changed.
The structure of the syndrome has been modified: it has now been established that different age groups are characterized by their own unique spectrum of localizations. New localizations are being discovered that were previously considered not typical for hTP53rc (for example, lung cancer in elderly patients aged 50 and over).
It was discovered that patients with hTP53rc should avoid genotoxic chemotherapy and radiation therapy due to the high risk of developing secondary tumors and focus more on surgical methods of treatment. So recently developed screening protocols include serious measures for the prevention of malignant neoplasms, since early detection of hTP53rc plays a significant role in increasing life expectancy. The diagnosis of hTP53rc in clinical practice is hindered in some cases, since it is not always possible to suspect the carrier of a hereditary mutation.
At the same time, the approaches of molecular diagnostics are becoming more accessible due to the rapid spread of next generation sequencing into laboratory practice. For this reason, the detection of mutations in the TP53 gene in the world has increased gradually.
In Russia, hTP53rc diagnostics is limited to the description of individual cases. Technological progress is likely to quickly eliminate the limitations in diagnosis, and the number of detected cases will grow from year to year. Regarding to treatment and prognosis, there are a number of features that require consideration of each case separately.
Neoadjuvant and adjuvant immunotherapy for non-small cell lung cancer (literature review)
Authors: Kharagezov Dmitrii , Lazutin Yrii , Mirzoyan Ellada , Milakin Anton , Stateshny Oleg , Leyman Igor
Published: April 2022

Significant number of patients with early and locally advanced non-small cell lung cancer (NSCLC) develops relapses after surgical treatment. Effective medical therapy preventing relapses in operable NSCLC is apparently still urgently needed. Immunotherapy with immune checkpoint inhibitors has become the main treatment for progressive NSCLC. Neoadjuvant checkpoint blockade is well tolerated without causing excessive toxicity and increased postoperative complications and mortality rates. Phase II clinical trials have shown promising results, and prospective phase III trials are currently underway. The role of adjuvant immunotherapy with checkpoint inhibitors is unclear and remains the subject of numerous prospective studies.
Quality of life in patients with rectal cancer with permanent stoma and low colorectal anastomosis
Authors: Денис Самсонов
Published: April 2022

In recent decades, not only the oncological results of surgical treatment of rectal cancer have been actively studied, but also the impact that it has on the quality of life of patients. In the minds of a wide range of medical specialists, the idea that the presence of a permanent stoma is the factor that has the most adverse effect on the quality of life in the long term after a surgical intervention has become stronger. However, a significant number of modern studies are not supporting this point of view, not finding a significant difference in the quality of life in patients with a permanent stoma and a low colorectal anastomosis.
Real-world data on the incidence of immune-related adverse events associated with anti-PD-1/PD-L1 treatment in Russia
Authors: Degtiareva Ekaterina , Protsenko Svetlana , Iyevleva Aglaya , Imyanitov Evgeny
Published: April 2022

Background. PD-1 and PD-L1 immune checkpoint inhibitors (ICI) show efficacy in many tumor types, and the indications for their use continue to expand. Meanwhile, treatment with ICI is often accompanied by specific immune-related adverse events (irAEs). The real-world data of the incidence of irAEs in Russian patients is lacking.
Objectives. The study aimed to characterize the frequency and profile of irAEs registered in Russian patients.
Materials and methods. The retrospective study included patients with various solid malignancies who received immunotherapy in N.N. Petrov National Research Institute of Oncology or other oncological institutions of St. Petersburg during 2018–2021. The following treatment regimens were used: monotherapy with anti-PD-1 monoclonal antibody (nivolumab, pembrolizumab or prolgolimab), anti-PD-L1 monoclonal antibody (atezolizumab) or combination therapy with anti-PD-1 and anti-CTLA-4 antibodies (nivolumab and ipilimumab). The frequency and spectrum of irAEs were evaluated depending on the treatment regimen.
Results. Any-grade irAEs were registered in 58 out of 178 (32.6%) analyzed patients. The most common adverse events were liver toxicity (11.2%) and thyroid dysfunction (10.1%). Severe irAEs (≥3 grade) occurred in 15.7% of cases. There was one fatal outcome due to grade 5 immune-mediated hepatitis. Combined immunotherapy was associated with a higher frequency of immune-related toxicity compared to monotherapy anti-PD-1/PD-L1 monoclonal antibodies (70.6% vs 23.6%, respectively, p<0.0001).
Conclusions. The reported frequency of adverse events of PD-1 and PD-L1 inhibitors in Russian patients was lower than in the majority of the foreign studies.
Treatment outcomes among patients with metastatic uveal melanoma: a retrospective monocentric study
Authors: Zherka Iryna Iryna , Naumenko Larisa , Zhyliayeva Katsiaryna , Evmenenko Alesia , Korsik Vladislau , Portianko Anna
Published: April 2022

Aim: to establish the dependence of cancer specific survival rate of patients with metastatic uveal melanoma on the treatment method, according to the Belarusian Cancer Registry.
Material and methods. We analyzed the data of the Belarusian cancer registry and medical records of patients diagnosed with metastatic uveal melanoma in the period from 2006 to 2015. Treatment methods included chemotherapy, radiation therapy, surgical removal of metastases, immunotherapy with roncoleukin. Hepatotropic therapy included hepatic artery chemoembolization, radiofrequency ablation of metastatic foci, or liver resection. We analyzed cancer specific 1-, 3-, 5- and 10-year survival of patients in treatment groups.
Results. The median cancer specific survival of patients who received only supportive care was 2.0 (95% CI 1.1–2.9) months, after any of the anticancer therapy methods application — 10.0 (95% CI 7.3–12.7) months. The median cancer specific survival in the chemotherapy group was 9.0 (95% CI 6.3–11.7) months, in the case of hepatotropic therapy — 20.0 (95% CI 10.9–29.1). The median cancer specific survival of patients receiving immunotherapy was 7.0 (95% CI 1.1–12.9), the survival plateau was reached after 48 months.
Conclusion. Metastatic uveal melanoma is characterized by a poor prognosis, including during therapy. Both hepatotropic and systemic therapy have limited efficacy. Further study of the tumor biology and immune microenvironment is required in order to determine possible targets of exposure.
Cápsulas de polvo de arándano como propuesta nutracéutica para mejorar la bioaccesibilidad de compuestos fenólicos
Authors: Tánori-Encinas Daniel , Wall-Medrano Abraham , Cárdenas-López José Luis , Ledesma-Osuna Ana Irene , Robles-Sánchez Maribel
Published: April 2022

Blueberry (Vaccinium corymbosum L.) has a high content of phenolic compounds which have been studied mainly for their antioxidant, antiobesogenic, anti-inflammatory activity, among others. Objetive. The objective of the present study was to evaluate the effect of in vitro gastrointestinal digestion on the bioaccessibility of phenolic compounds and antioxidant activity of a nutraceutical formulation of blueberry (capsule), compared to fresh and powder blueberry. Materials and methods. Methanolic extracts of fresh and lyophilized blueberry were obtained and determined its total phenols, flavonoids, anthocyanins content, as well as antioxidant activity. A gastrointestinal digestion simulation test also was carried out to assess the bioaccessibility of the phenolic compounds found in samples. Results. The results showed that gastric digestion of powder and capsule blueberry promoted greater bioaccessibility of phenols (42% and 40%), flavonoids (52% and 33%) and anthocyanins (45% and 40%), compared to fresh blueberry digests. After intestinal digestion, the bioaccessibility of phenols (63%) and flavonoids (67%) was higher in the blueberry capsule compared to its powdered blueberry counterpart. The intestinal digestion conditions negatively affected the bioaccessibility of anthocyanins regardless of the type of sample evaluated. Conclusion. Gastric digestion conditions promote greater stability of phenolic compounds in powdered and capsule blueberries, which could be relevant for the maintenance of an antioxidant environment at this level. The intestinal digestion conditions particularly affected the phenolic compounds of fresh and lyophilized blueberry, but not the capsule, which may suggest that encapsulation protected the phenols present from alkaline conditions. Further studies on in vitro absorption of the remaining components in the intestine and their possible effects on oxidative stress biomarkers in in vivo models are suggested.
Probiotics in Crohn's disease remission: a systematic review
Authors: Pontes Azevedo Kamilla , Catulio Maria Zilda de Jesus , Machado de Souza Rávila Graziany , Ferreira Stringhini Maria Luiza
Published: April 2022

Crohn's disease (CD) is an inflammatory condition that can affect the entire gastrointestinal tract due to an exacerbated and inadequate immune system response. Objective. This study aimed to conduct a systematic review, through clinical trials, about the use of probiotics in humans with CD. Materials and methods. Research was carried out in the PubMed, Scopus and Science Direct databases using the keywords “Crohn's disease” and “probiotics”. We conducted the review by searching clinical trials published from 2000 to December 2019. Results. Of 2,164 articles found, only nine were considered eligible for this review. The studies investigated patients with CD at different stages of the pathology, and in three studies the potential effect of probiotics in the active phase was observed; in two, in the remission phase; and in four, after intestinal surgery. The sample size of the studies ranged from 11 to 165 individuals and the age of the participants between 5 and 71 years. Gram-positive bacteria were used in six clinical interventions and in two studies yeasts were used. As for the significant results obtained with the treatment with probiotics, in one study there was beneficial clinical effects in patients and, in another, there was an improvement in intestinal permeability. Conclusion. Currently, it is not possible to establish a recommendation for probiotic therapy to control CD due to the few clinical trials with significant results. There is a need for more research on clinical intervention with probiotics in CD to clarify the action, define doses and time of use.
Displasia arritmogénica del ventrículo derecho: un “popurrí “ de nombres que crea confusión
Authors: Spina Salvador
Published: April 2022

En este editorial revisamos la terminología, a veces confusa, que utilizamos para describir y diagnosticar la miocardiopatía arritmogénica del ventrículo derecho.
Síndrome de hipoplasia ventricular izquierda. Diagnostico prenatal
Authors: Biancolini María Fernanda , Biancolini Julio César , De Dios Ana María
Published: April 2022

El síndrome de hipoplasia de corazón izquierdo es una cardiopatía congénita crítica que requiere cuidados perinatales específicos. El adecuado diagnóstico intraútero y seguimiento evolutivo permite estratificar el riesgo y determinar el pronóstico pre y postnatal. Entre los determinantes de mayor relevancia encontramos la restricción del foramen oval, la insuficiencia tricuspidea y la disfunción ventricular derecha.
Tips para el diagnostico de trombosis venosa profunda
Authors: Casas Jorge , Corneli Mariana , Perea Gabriel
Published: April 2022

La trombosis venosa profunda (TVP) es frecuente y, asociada al tromboembolismo pulmonar (TEP), supone la tercera causa de muerte cardiovas­cular después del infarto agudo de miocardio y accidente cerebrovascular, y la primera causa de muerte cardiovascular en la hospitalización. Con la sospecha clínica, el método de imagen inicial obligatorio será el ultra­sonido, que posee alta sensibilidad (> 90%) y especificidad (> 95%), La falta de compresibilidad venosa es el principal elemento diagnóstico. La visualización directa del trombo será altamente específica de TVP.
Modo M color. Un método sencillo para colocar los flujos cardíacos en el tiempo
Authors: Gómez de Diego José Juan , García Fernández Miguel Ángel
Published: April 2022

El modo M color es un modo ecocardiográfico muy sencillo que permite estudiar de forma sencilla y elegante la posición de los flujos cardíacos en el tiempo. Revisamos de forma breve cómo se realiza.
Utilidad de la Cardio-RM en la insuficiencia cardiaca
Authors: Rodriguez Hernandez Juan Lizandro , Sufrate Sorzano Elena , Alonso Pérez Luis , Azcárate Agüero Pedro María
Published: April 2022

La insuficiencia cardiaca es un síndrome clínico, causada por una anomalía cardíaca estructural y / o funcional, lo que resulta en un gasto cardiaco reducido y / o presiones intracardiacas elevadas en reposo o durante el estrés. Para poder tratar de forma adecuada a los pacientes con este síndrome clínico es muy importante poder realizar un diagnóstico preciso que nos permita identificar la etiología subyacente. Por este motivo las técnicas de imagen juegan un papel crucial en el diagnóstico y en el tratamiento de la insuficiencia cardíaca. Revisamos como la Cardio-RM es una técnica de referencia en estos paciente.
Cardiomiopatía por Covid-19: reporte de un caso en un paciente previamente saludable
Authors: Villarroel Ábrego Hugo , Flores Ventura Ana Camila , Alonzo Corpeño Amanda Mercedes
Published: April 2022

Paciente masculino de 30 años, sin comorbilidades mayores, que presentó neumonía hipóxica por COVID-19, recuperándose eventualmente. Cursó con bradicardia, ectopias ventriculares, reducción de la fracción de eyección del ventrículo izquierdo e hipertensión pulmonar leve. La resonancia magnética cardiaca confirmó disfunción sistólica izquierda, con deterioro del strain longitudinal; el ventrículo derecho mostró fibrosis intramural de pared libre y también marcada reducción del strain. Se descartaron edema parietal o patologías infiltrativas, y al cabo de varios meses revirtió la falla ventricular. Se discute el potencial daño cardíaco causado por el SARS-CoV-2 aún en sujetos jóvenes sin comorbilidades documentadas.
Trombosis intracardíaca asociada a cable de marcapasos en paciente con síndrome antifosfolípido
Authors: Povar Echeverría Marina , Hurtado Rodríguez Gabriel , Moreno Esteban Eva María , Auquilla Clavijo Pablo Esteban
Published: April 2022

Presentamos el caso de una paciente portadora de marcapasos definitivo bicameral que ingresa con el diagnóstico inicial de tromboembolismo pulmonar. En el TC realizado se observa un defecto de repleción localizado en aurícula derecha (AD). Se realiza ecocardiograma transtorácico que muestra una masa móvil de gran tamaño e AD adherida al electrodo de marcapasos auricular compatible con trombo por sus características y localización. En el estudio se detectó la presencia de síndrome antifosfolipido como causa protrombótica predisponente. Dada la estabilidad clínica de la paciente se optó por tratamiento médico con anticoagulación de forma indefinida.
Estenosis de venas pulmonares sospechada por ecocardiografía de estrés con ejercicio en un paciente post aislamiento de venas pulmonares
Authors: Bedoya Jaramillo Tatiana María , Duarte Suárez Néstor Ricardo , Escobar Franco Álvaro , Duque Ramírez Mauricio
Published: April 2022

La estenosis de venas pulmonares (EVP) es una complicación grave que se ha asociado a la ablación por radiofrecuencia (ARF) como tratamiento de la fibrilación auricular (FA). Su incidencia puede ser tan baja como 0.3%, pero podría aumentar por múltiples variables. El tiempo promedio de diagnóstico es de 16 semanas. Presentamos el caso de un paciente que consultó por disnea seis meses después de la ARF, se realizó una ecocardiografía de estrés con ejercicio en la que se sospechó EVP. Se describen los hallazgos que pueden sugerir dicha complicación y proponemos esta herramienta para la valoración inicial de disnea post ARF.
Higher BNP/NT-pro BNP levels stratify prognosis equally well in patients with and without heart failure – a meta-analysis with more than 89,000 patients
Authors:   West German Heart and Vascular Center, University Hospital Essen, Hendricks Stefanie , Dykun Iryna , Balcer Bastian , Totzeck Matthias , Rassaf Tienush , Mahabadi Amir A.
Published: April 2022

Review question / Objective: We performed a meta-analysis to investigate, whether the value of BNP/NT-proBNP as predictors of long-term prognosis differentiates in cohorts with and without heart failure. Condition being studied: The standardised cut-off levels for BNP and NT-proBNP that are currently used in clinical practice are based on the stratification of patients with heart failure. In patients without heart failure, however, relatively lower values are observed. This leads to the assumption that the prognosis for patients with BNP/NT-proBNP levels at the upper limit of the normal range might be worse than the prognosis for patients with BNP/NT-proBNP levels lower in the range, even if both are determined to be within the normal boundaries. However, a specific cut-off level of BNP/NT-proBNP for the prediction of prognosis in patients without heart failure has not yet been determined. Therefore, we performed a meta-analysis of existing studies investigating the value of BNP/NT-proBNP as a predictor of long-term prognosis in patients with heart failure and the general population.
The methods of biofuel generation by using microalgae: A review
Authors: Alkhodairy Hanoof
Published: April 2022

Biofuels researchers extended to fit the growing fuel requirements and protected regional energy. Because of renewable and no impact on carbon biomass is preferred to replace fossil fuels. 2nd generation biofuels generated from micro-algae and lignocellulosic biomass (3rd generation biofuels) have become an essential raw material for the generation of renewable biofuels. Microalgae are rapidly multiplying microorganisms seen in the water, are the essential raw material for bio-fuel generation for the features like huge growth ratio, yield per area, potency in CO2 capture, and solar energy transformation. Photobioreactors on marginal lands, ponds, and seawater is the best growing area for algae, industries also cultivate the algae. Many methods have been used for the generation of biofuels from algae includes anaerobic digestion, hydrothermal liquefication, supercritical water gasification, and pyrolysis. This review article in brief explains the process of biofuel generation by using microalgae.
Prescribing Pattern Analysis of Drugs in the patients with Gastrointestinal Disorders
Authors:   Jagan’s Institute of Pharmaceutical Science, Nellore, Nandini A , SaiSavalli A ,   Jagan’s Institute of Pharmaceutical Science, Nellore, Sravanya T ,   Jagan’s Institute of Pharmaceutical Science, Nellore, Jagan Mohan Rao G ,   Jagan’s Institute of Pharmaceutical Science, Nellore, Narayana swamy P ,   Jagan’s Institute of Pharmaceutical Science, Nellore, Venkatesh p ,   Jagan’s Institute of Pharmaceutical Science, Nellore
Published: April 2022

Aim: The aim of the study is to evaluate Clinical profile & Prescribing Patterns of Drugs in patients with gastrointestinal disorders. Materials and Methods: Patients who were diagnosed with gastrointestinal disorders of either gender and with an age of above 18 years were included in this study. Results: Among the 240 study participants, In our study, we have observed over 120 cases of Gastro-Intestinal Disorders. Among 120 control subjects, all of them were suffering from either of the Gastrointestinal Disorders. 63.33% of the subjects were Male and 36.66% of the subjects were Female. Among the subjects belonging to age group 20-40 years, 14.16% were Male and 6.66% were Female. Among the subjects belonging to age group 40-60 years, 32.5% were Male and 11.66% were Female. Among the subjects belonging to age group 60-80 years, 17.5% were Male and 6.66% were Female. Among the subjects belonging to the age group above 80 years, 8.33% were Male and 2.5% were Female. Conclusion: In our study, we noticed that the incidence of GI disorders was more in males (63.33%) compared to females (36.66%) and also the people who were in the age of 40 to 60 years were more affected compared to the younger ones. We have also reported the alcoholics (45.83%) and smokers (46.66%) were more prone to gastritis (44.16%) and pancreatitis (24.16%) than the normal population
INITIATION AND EVALUATION OF DRUG INFORMATION SERVICES PROVIDE IN NELLOE DISTRICT
Authors:   Jagan’s Institute of Pharmaceutical Science, Nellore, Sameera sk , Asha Margaret B ,   Jagan’s Institute of Pharmaceutical Science, Nellore, Mounika T ,   Jagan’s Institute of Pharmaceutical Science, Nellore, Narayana swamy p ,   Jagan’s Institute of Pharmaceutical Science, Nellore, Venkatesh P ,   Jagan’s Institute of Pharmaceutical Science, Nellore
Published: April 2022

Aim: The aim of this study was to evaluate the quality of drug information services provided in Nellore district. Materials and Methods: To provide unbiased drug information by modified systematic approach. Shows that Queries are received from various health care professionals through Hospital and classified as per educational status like Nutritionist, Lab technicians, social workers. More queries are received Nutritionist from hospital. Results: Results are predicted as Nutritionist (1.09%), lab technicians (1.09%), social worker (0.54%). Among the non-judgmental type, 25 queries were randomly selected and analyzed, 52%had a rating of 5 and 44% had a rating of 4. This indicates all responses satisfied the minimum acceptable level of quality. Non-judgmental responses did not require extensive searching and clinical judgment and thus the clinical pharmacist could answer such enquiries effectively. Conclusion: In our study we conclude that the pharmacists in other hospitals all over the Country would appreciate the value of their involvement in pharmaceutical care and attempt to extend their services for better patient care in the hospital.
Military application study of BCI technology using brain waves in Republic of Korea Army
Authors: Oh Janggil , Kim Jongheon
Published: April 2022

The importance of reserve forces is increasing owing to changes in the security environment, such as the promotion of Defense Reform 2.0 and a sharp decrease in military service resources. Under these changes, we focus on combining EEG (ElectroEncephaloGraphy) with Brain-Computer Interface (BCI) for improving combat power and contributing to the future development of defense science and technology in 2050. In the study of EEG measurement technology, the alpha wave of calmness and beta wave representing the improvement of the concentration on individualized shooting skills, were measured with high accuracy in the theta wave-related research, and the value of their use was recognized. Using in the combat situations of personal firearms shooting, it can be applied in a small budget and a short period of time. Through our findings, when shooting the K-1 and K-2 rifles (the basic personal weapons in Korean military), it can contribute to improving the accuracy of existing individual’s shooting by increasing both concentration and calmness between breathing and firing control. Hence, our study show in the future warfare, the new direction of current defense science and technology and new concept of personal weapon usages in artificial intelligence based on hyper-intelligence, hyper-connectivity, and human-unmanned combat systems.
The characteristics of China’s military negotiation strategy
Authors: Kang Yeungtae
Published: April 2022

It was observed from the Korean War ceasefire talks, China-Soviet border disputes, India-China border disputes, Hong Kong return negotiations, and South China Sea conflicts that China adopted distributed negotiation strategy. Furthermore, the purpose of this paper is to derive an effective approach by identifying the types of military negotiation strategies used by China in conflicts with neighboring countries. Such research can contribute to the expansion of research topics on security-political-military relations owing to recent changes in the regional security environment (North Korea, the United States, Japan, and China) surrounding the Republic of Korea. Through the literature of various case studies, it was observed that China’s negotiation strategy differed depending on the attitude or response demonstrated by the target country. Thus, it could be confirmed that China's hostile negotiations alter and reach an agreement if the negotiator acquires military victories, exercises tough measures that threaten the negotiations themselves, or exerts diplomatic all-out pressure. This cannot be achieved by military methods alone. For instance, in the case of the South China Sea dispute, strong diplomatic pressure transformed China's negotiation strategy into an integrated negotiation strategy.
Factors affecting information security compliance intention of military officer
Authors: Kim Sangyoung , Lee Taebok
Published: April 2022

The purpose of this study is to analyze the factors that influence the information security compliance intention of Korean military officers. For this purpose, a research model was constructed focusing on information security compliance attitude and perceived control, which are the main variables of the theory of planned behavior. In addition, security sensitivity, organization trust, information security work impediment, and sanction, were selected as independent variables. The research model was analyzed through a survey targeting Korean army officers, and the results are as follows. First, security sensitivity, organization trust, and sanctions had a significant effect on information security compliance attitude. However, the effect of information security work impediment had not been identified. Second, it was analyzed that security sensitivity and organization trust had a positive effect on perceived information security compliance control, but the effect of information security work impediment and sanction had not been verified. Third, it was confirmed that the information security compliance attitude and perceived control affect the information security compliance intention, which reconfirmed the results of previous studies. This study is meaningful in that it can improve the information security level of the military organization by suggesting a way to manage these factors.
CEMİL SENA ONGUN’UN “FİKİR KIRINTILARI”NDA SOSYAL DARWİNİST YANSIMALAR
Authors: ERGÜN Ragıp
Published: April 2022

Bu çalışma Tek Parti Dönemi aydınlarından Cemil Sena Ongun’un Varlık Mecmuasındaki uzun metrajlı “Fikir Kırıntıları” başlıklı yazı dizindeki sosyal Darwinizmin etkisini anlamaya odaklanmaktadır. 19. yüzyılın ikinci yarısından başlayarak 20. yüzyılın ikinci yarısına kadar Batı düşüncesini etkileyen yaklaşımlarından olan sosyal Darwinizm, insanı biyolojiye indirgemekte, içtimai yaşamı bu düzlemde inşa etmeye çalışmaktadır. Başta Avrupa olmak üzere dünyanın pek çok ülkesinde uygulama alanı bulan sosyal Darwinizm, Tek Parti Dönemi aydınlarının da dikkatini çekmiş ve bu insanları oldukça fazla etkilemiştir. Bu yüzden dönemin devlet ideolojisini yansıtma ve inşa etme iddiasında olan Varlık Mecmuası’nın yazarlarından Cemil Sena Ongun’un “Fikir Kırıntıları” yazı dizisinin anlaşılması önem arz etmektedir. Bu yazı dizisinde Cemil Sena, Tanrı fikrinin tekâmülünden insanın ontolojik anlamına, ahlak mefhumunun mahiyeti ve kökeninden “tarih evvel” zamanların nasıl anlaşılması gerektiğine kadar pek çok konuya değinmiştir. Bu konuları/kavramları sosyal Darwinist perspektifle inceleyen Cemil Sena bu yaklaşımı doğrudan kullanan ve savunduğunu da açıkça ifade eden nadir Cumhuriyet dönemi aydınları arasındadır. Bu nedenle Cemil Sena’nın “Fikir Kırıntıları”ndaki sosyal Darwinist etkinin anlaşılması dönemin düşünce dünyasının anlaşılması için oldukça önemlidir.
ONLİNE ALIŞVERİŞTE MARKA İMAJININ ONLİNE SATIN ALMA NİYETİ VE AĞIZDAN AĞIZA İLETİŞİM DAVRANIŞI ÜZERİNE ETKİSİ; AMPRİK BİR ÇALIŞMA
Authors: SAYDAN Reha , DÜLEK Bulut
Published: April 2022

Bu çalışma çevrimiçi alışverişte marka imajının ağızdan ağıza iletişim ve online satın alma niyeti üzerinde etkisinin analiz edilmesi amacıyla gerçekleştirilmiştir. Bu doğrultu da online alışveriş deneyimine sahip tüketicilerle anket uygulaması gerçekleştirilmiştir. Araştırma amacı doğrultusunda oluşturulan araştırma modeli ve kurulan hipotezler regresyon analizi ile test edilmiştir. Yapılan analizler sonucunda marka imajının hem ağızdan ağıza iletişim üzerinde hem de online satın alma niyeti üzerinde olumlu yönde etkili olduğu görülmüştür. Ayrıca ağızdan ağıza iletişiminde online satın alma niyeti üzerinde olumlu bir etkiye sahip olduğu sonucuna da ulaşılmıştır.
Prinsip Pelaksanaan Puasa Menurut Yoel 2: 12-17 Bagi Kekristenan Masa Kini
Authors: Siregar Esron Mangatas
Published: April 2022

This research is motivated by the existence of problems in Christianity that reject the implementation of fasting, differences in the concept of implementing fasting, a less firm basis in understanding fasting in the Christian concept, and wrong motives in carrying out fasting. Through qualitative research methods and descriptive analysis through literature studies, specifically the text of the Book of Joel 2:12-17. The results of the analysis show that Joel 2:12-17 calls for fasting with the first principle: following the word of God because God is merciful and merciful, God is long-suffering and abundant in faithfulness. Second, turn to God with all your heart, cry and moan. Third, tear the heart and Fourth humble yourself. Thus there is a restoration of the relationship between man and God and a focus on God's will, all of which straighten out the wrong practice of fasting.
Konsep Terikat Dan Terlepas Dalam Matius 16: 19 Dan Implikasinya Bagi Pemimpin Gereja
Authors: Muryati Muryati , Abrillian Melvin , Marbun Purim , Setianto Yusak
Published: April 2022

Authority is always attached to a leader, including church leaders. However, the problem is that there are some leaders who abuse authority for their own interests. There are also other leaders who cannot use an authority in determining doctrinal and ethical matters. Therefore, this study aims to explain the authority of the disciples to bind and release the law in Matthew 16:19 and its implications for today's church leaders. This research method is qualitative with a hermeneutic approach based on a literature study. The results of the study show that the authority was given by God to expand His kingdom on earth so church leaders must use this gift for His glory and improve the quality of the congregation that God has entrusted to him.
Studi Teologis Makna Menghujat Roh Kudus Menurut Injil Sinoptik Sebagai Dosa Yang Tidak Diampuni
Authors: Baskoro Paulus Kunto , Purdaryanto Samuel
Published: April 2022

Sin is an attitude that destroys human life (Ps. 32: 3-4; 51: 4, 7). Since the fall of the first man in the garden of Eden, all humans have been under the bondage of sin (Gen. 3; Rom. 5:12-14). Over time, all attempts at repair fail and one error leads to another (Isa. 64:6; Rom. 3:10-12). Various issues regarding the sin of blaspheming the Holy Spirit as an unpardonable sin have caused anxiety in the hearts of believers because they think they have committed the sin without realizing it. This study uses the descriptive method of literature as the method used to describe or present the results based on a literature review as well as by extracting hermeneutics and exegesis of texts in the synoptic gospels. The purpose of this study is, first, to describe the notion of blaspheming the Holy Spirit as an unpardonable sin, using appropriate and biblical principles. Second, compare the results of the interpretation with several interpretations that contrast with the statements of the Bible in other parts that take all sin seriously (Rom. 6:23). Third, every believer has a complete understanding of the meanings of sin, so that they can seriously live in Christ.
Ayah Teladan Sebagai Peletak Dasar Iman Anak
Authors: Nggebu Sostenis , Chung Yusnoveri
Published: April 2022

The problem of this research is that there is a phenomenon that children need an exemplary father in fostering their faith, so that they experience a personal encounter with God in Jesus Christ, believe in Him, and obey His word. This article uses literature study. The results reveal that the child's introduction to God is the responsibility of the father as the head of the family as well as the spiritual leader for all members of the family. Fathers nurture children spiritually so that they have a close relationship with God, experience new life in Jesus Christ and be able to overcome temptations and still rely on Jesus Christ in the midst of the restlessness of the world. Active involvement in spiritual development will have a positive impact on children's lives so that children enjoy their growth and development in a healthy and meaningful way. Children can also record a father figure leadership model for the child's self-development. And in the future the child will be able to carry on this impact in his life, in particular becoming a potential model father for his son.