bluuebunny/crossref_metadata_2025 huggingface dataset:
Session 8 - Deciphering the SUMO code for adaptive responses in plants
Authors: Sadanandom Ari
Published: July 2023

Post-translational modification (PTM) events generate proteoforms that orchestrate cell signalling in almost every biological process. The SUMOcode project aims to understand a critically important but understudied PTM in plants, SUMO (Small Ubiquitin-like Modifier). The rules governing specificity and function remain rudimentary for most PTMs, but the plant SUMO system provides a unique possibility to unravel the rules governing SUMOylation, as its core machinery comprises only 33 genes in Arabidopsis, compared with many hundreds for other PTMs.

Our central hypothesis is that SUMO specificity is conferred through how cells are primed to respond to different stress signals, the tissue and cellular spatial distribution of SUMO machinery and substrates and control of SUMOylation modification via activation, repression and competition for PTM sites.

We have developed a SUMO system cell atlas (a resource that will characterize each part of the machinery), how and in which cells and when it works, so that a map of the key events that trigger a SUMOylation response to environmental cues can be revealed.
Session 9 (Part 1) - Rejuvenation, reproduction, and regeneration: resetting the plant juvenility clock
Authors: Wang Jia-Wei
Published: July 2023

Multicellular organisms undergo several developmental transitions during their life cycles. In plants, the juvenile phase differs from the adult phase in terms of floral competence and morphological and anatomical traits in successive leaves. In this talk, I will first demonstrate that the juvenile phase is essential for plant reproductive success and that a high level of microRNA156 (miR156) and cell quiescence are two key factors for maintaining juvenility in plants. I will then discuss how the plant juvenility clock is reset through various pathways. Specifically, I will illustrate how plants develop a robust mechanism to ensure accurate restoration of the juvenile phase in each generation, and how this similar principle is also adopted for the reset of juvenility during de novo shoot regeneration.
Kualitas Pengungkapan Management Discussion And Analysis (MD&A) Perusahaan Fortune 45 Dengan Model WEBB
Authors: Reza Muhammad
Published: July 2023

Jurnal ini bertujuan untuk mengevaluasi langsung atas kualitas pengungkapan Management Discussion and Analysis (MD&A) Pada Perusahan TOP 45 Fortune dengan model Webb. Penelitian ini dilakukan pada perusahaan TOP 45 di Fortune dengan pendekatan Metode Case Study Teori MD&A model Lori Holder Webb. Makalah ini memberikan lebih banyak alat intensif untuk mengevaluasi pengungkapan kualitatif yang terkandung dalam MD&A daripada yang saat ini tersedia untuk umum. Alat ini menghasilkan kuantitatif ukuran pengungkapan yang dapat digunakan dalam penelitian empiris atau eksperimental untuk penelitian lebih lanjt, atau oleh mereka yang ingin membandingkan pengungkapan secara objektif di seluruh manajer, lintas perusahaan, atau lintas waktu. Kebaruan dalam penelitian ini adalah bagaimana MD&A melakukan Content Analysis Kualitas pengungkapan Management Discussion & Analaysis Perusahaan Fortune TOP 45 dimana dalam penelitian sebelumnya Laporan MD&A terhambat oleh kurangnya alat empiris untuk memungkinkan analisis objektif pengungkapan kualitatif.
Women’s Suffrage Through the CLIL Approach
Authors: Buchara Sabrina , Catalán Soto Fernanda , Gutierrez Estefanía , Galindez Daiana
Published: July 2023

The aim of this article is to improve and develop students’ critical thinking as well as their linguistics skills by making use of the CLIL approach. Focusing on relevant topics in today's society such as the voting system is an interesting opportunity not only to motivate students' learning, but also to be aware of the world they live in. The activities are designed for students around the voting age in Argentina with an intermediate level of English. Through the development of writing and speaking skills and collaborative work, students will be aware of the importance of past events such as the women’s suffrage, and social differences that are still happening all over the world.
Effect of super-chilled preservation on the water-holding properties of fresh beef during storage
Authors: WEN Yongping , LIU Dayu , LLIU Yang , LIU Lijia , WANG Xinhui
Published: July 2023

In this study, comparison of the effects of chilled (4 °C), super-chilled (-4 °C), and frozen (-18 °C) storage on the water-holding properties was evaluated by drip loss, surface hydrophobicity, and calpain activity of raw beef. These results indicated that storage temperature can significantly affect the water-holding properties. In contrast to chilled storage, super-chilled storage can maintain a higher thiol group content, which can maintain better myofibrillar protein hydration capacity. Furthermore, super-chilled storage effectively slowed down the increase in the rate of protein hydrophobicity compared with chilled and frozen storage. Additionally, the super-chilled sample exhibited the highest glutathione reductase activity, followed by the frozen sample. These results revealed that super-chilled storage is a good way to preserve the water-holding properties of raw beef.
Development of entrepreneurship in circular cities as consituents of circular world economy
Authors: Kaim Marina , Shishcan Zorina
Published: July 2023

The authors explore the development of the contemporary entrepreneurship in such a new form of cities as “circular city”. In doing so, they reveal various modes and approaches to the entrepreneurship. They also argue for the fact that the combination of a circular city with green and smart concepts, call forth the development of the sustainable entrepreneurship. Due to the development of the latter, the circular cities become the constituents of the future world economy. The authors combine analytical conceptual approach with international case studies in their research.
Clinical and hardware evaluation of moisturizing properties and tolerability of a emollient cream with filagrinol (“Admera”) in atopic dermatitis in children
Authors: Masalskiy S. S. , Smolkin Yu. S. , Smolkina O. Yu.
Published: July 2023

Objective. Evaluate the possibility of using a cream with 5 % filagrinol ("Admera") in children (0-18 years old) as an emollient in atopic dermatitis (AtD) and receive hardware measurements of skin hydration.

Materials and methods. Open interventional study in parallel groups of children with AtD 0-18 years old (n = 72, median age 6 [3.75; 7.0] years). 2 equal groups: group 1 received methylprednisolone cream 1 time daily on lesions for 14 days + Admera emollient on the other skin; group 2 received the same treatment + cream with filagrinol 5 % applied from day 5 on the lesions.

Results. Standard therapy with topical steroids and emollients was effective. The severity indices during steroid + emollient treatment decreased significantly: EASI 11.5 [6.0; 17.0] vs 2 [1; 3.8] scores, p < 0.001; skin lesion area from 17.5 % [10.0; 26.8 %] to 3.5 % [1.25; 6.0 %], p < 0.001; IGA score — 2 [2; 3] vs 1 [1; 2], p < 0.01.

The total itching score for AtD (max 10) became significantly lower with therapy: nocturnal itching decreased from 3 [1; 7] to 1 [1; 3] and daytime itching from 4 [3; 7] to 2.5 [1; 4] points, p < 0.01.

The mean values of hardware-measured skin hydration outside the lesion areas were 8 [6.0; 12.0] units at baseline. After 14 days of emollient, hydration of dry clear skin increased to 10 [8.0; 15.0] units (p = 0,017). The hydration of the skin on the affected areas increased significantly from 8 [6; 10] to 12.0 [8; 15] units (p = 0.001).

The patients' organoleptic evaluation of the cream was 4.48 (max 5). No serious or moderate adverse events (AEs) were reported in this study. In 11.3 % of cases, the skin itching was detected, but resolved rapidly without treatment.

Conclusion. The cream with 5 % filagrinol (“Admera”) significantly improved skin hydration, as measured instrumentally, in the area of dermatitis and dry skin without ones. The cream caused no significant adverse reactions and could be used together with topical steroids.
The use of antibacterial drugs in the treatment of coronavirus infection in children in real outpatient clinic practice
Authors: Ginzburg A. S. , Kiryutkina A. P. , Migacheva N. B.
Published: July 2023

Introduction. In light of the available data on the unjustified use of antibiotics in children with acute respiratory viral infections, the frequency of prescribing antibacterial drugs to children with a new coronavirus infection in real clinical practice is of great practical and scientific interest.

The aim of the study was to study the frequency of antibiotic therapy and identify factors that increase the risk of needing antibiotics in children with coronavirus infection at the outpatient stage.

Materials and methods. A retrospective cross-sectional study was conducted on the basis of children's polyclinics in Samara from November 2021 to July 2022, which included a survey of parents and an analysis of outpatient records of 100 children who were under outpatient observation and treatment for COVID-19. An analysis was made of the frequency of prescribing antibiotics to them and potential factors predisposing to their prescribing to children with COVID-19. The obtained data were subjected to statistical processing using the IBM SPSS Statistics 25 program and a comparative analysis.

Results. The frequency of use of antibiotic therapy according to the results of the study was 11 % and did not exceed the Russian average data (14.3 %). When analyzing the factors influencing the doctor's decision to prescribe an antibiotic to a child with coronavirus infection, the most important were a history of recurrent respiratory infections (children from the FIC group), as well as the presence of concomitant diseases and background conditions in children, primarily chronic bronchopulmonary diseases. and nervous system.

Discussion. The prescription of antibiotics for children with a new coronavirus infection at the outpatient stage remains empirical due to the limitations of the use of laboratory and instrumental methods for additional examination of the child, which objectifies the likelihood of a secondary bacterial infection. Despite this, the frequency of antibiotic use according to the results of the study was 11 % and did not exceed the Russian average data (14.3 %), as well as the average frequency of antibiotic use for acute respiratory viral infections in children in the Russian Federation (21.5-23.3 %).
Launching blog administration self-service in Rogue Scholar
Authors: Fenner Martin
Published: July 2023

This week I added blog administration self-service to the Rogue Scholar blog archive. This makes adding a blog to Rogue Scholar easier, faster, and cheaper. To start blog administration please create an account with Rogue Scholar. Use the "Sign In" Link in the upper right corner to sign in or create an account with username and password, or sign in via Google or GitHub. Once signed in, you can add your blog via the Dashboard page.
A study on the current situation and causes of smoking among college students
Authors: Deng Guang , Yan HuiBing , Chen Esther , Huang Bowen , Zhang Heng
Published: July 2023

The total number of smokers worldwide is now more than one billion, accounting for about a quarter of the world's population, and tobacco use causes more than five million deaths worldwide each year. While smoking brings people pleasure, the toxic substances produced by the ignition of cigarettes can cause a variety of diseases. The data was collected from each school through a questionnaire and distributed online. For the questionnaire data, this paper uses C5.0 decision tree, chi-square test, logistic regression, and structural equation modeling to investigate the basic situation, causes, and influencing factors of smoking among college students, and to provide useful reference for improving the smoking situation among college students. In this paper, Fujian Medical University, Sunshine College, Fujian Information Vocational and Technical College, Fujian Arts Vocational College, Fujian Early Childhood Teacher's College, Jimei University, Chengyi College of Jimei University, and Jiageng College of Xiamen University were selected as the overall sample.
Strategi Islamic Branding Lembaga Fintech Syariah dalam Menarik Minat Funder dan Beneficiary: Studi pada ALAMI Fintech Sharia
Authors: Alannawa Sonia Rosta
Published: July 2023

Data BPS tahun 2010 menyebutkan jumlah populasi umat muslim di Indonesia sebanyak 207,2 juta jiwa menjadikan Indonesia sebagai pertimbangan para produsen dalam mengembangkan potensi pangsa pasarnya. Dari banyak perusahaan startup muslim global yang telah berdiri di Indonesia, ALAMI Fintech Sharia menjadi salah satu yang banyak diminati publik karena memiliki produk investasi P2P Lending berbasis syariah dengan tingkat keberhasilan yang signifikan. Keberhasilan penerapan strategi marketing Islamic branding di ALAMI membuat penulis

tertarik meneliti hal ini. Metode penelitian menggunakan metode penelitian kualitatif. Sumber data yang digunakan berupa data primer dan data sekunder. Hasil penelitian menunjukkan strategi ALAMI diantaranya dari nama perusahaan yaitu singkatan dari Alif Lam Mim jelas membawa unsur islami, memiliki tampilan website mengenai produk syariah yang transparan, memberi banyak tawaran promosi pembiayaan berbasis islami yang berlandaskan pada fatwa DSN-MUI, dan menggunakan akad pembiayaan syariah. Ketertarikan para Funder dan Beneficiary dalam melakukan P2P Lending Sharia banyak dipengaruhi atas strategi Islamic branding yang diterapkan ALAMI meliputi segi keberhasilan pembiayaan, pelunasan pembiayaan yang tepat waktu dan jaminan uang kembali. Dengan demikian peneliti menarik kesimpulan bahwa strategi Islamic Branding yang diterapkan oleh PT. ALAMI Fintech Sharia bisa memudahkan dan berpotensi menarik minat serta kepercayaan para Funder dan Beneficiary dalam melakukan pembiayaan.
ANADOLU MASALLARINDA TİLKİ MOTİFİ
Authors: YILDIZ Leyla Ece , GÖDE Halil
Published: July 2023

En eski dönemlerden beri hayvanlarla etkileşim halinde olan insanlar hem hayvanların etinden sütünden yararlanmış hem de iyi bir gözlemci olarak hayvanların davranışlarını gözlemlemiş ve bu hayvanları ürettikleri edebi eserlere dahil etmişlerdir. Bu hayvanlar edebi metinlerde ya kahramanın ta kendisi ya da kahramana yardım eden bir varlık olarak karşımıza çıkmaktadır. İnsanlar oluşturdukları bu edebi ürünlerde özellikle de masallarda doğada iletişim halinde oldukları hayvanların özelliklerini sembolleştirerek kullanır. Eşeği inatçı, ayıyı ahmak, aslanı güçlü gösterirken tilkiyi genellikle olumsuz, kurnaz, hilekâr ve hainliğin sembolü olarak gösterir. Anadolu masallarında tilki genellikle kötü özellikleri ile yer almasına rağmen yer yer tilkinin iyi özellikleri ile de karşılaşılmaktadır. Söz konusu çalışmada tilkinin olumlu özellikleri üzerine durulacaktır.
ORDU/FATSA YAPRAKLI MEZARLIĞI VE TARİHİ MEZAR TAŞLARI
Authors: TALİ Şerife
Published: July 2023

Fatsa Yapraklı Mezarlığı’nda bulunan tarihi mezar taşları bu araştırma ile kayıt altına alınmış ve eserler bilimsel olarak ilk kez incelenerek tanıtılmıştır. Tahribatın ve kayıpların fazla olduğu ayrıca yeni definlerin de sürdüğü mezarlıkta, tarihi olan mezarlar değerlendirilmiş ve eserlerin kitabeleri okunmuştur. Mezarlar, mezar tipolojisi, şahidelerin mal-zeme, teknik, form ve bezeme özellikleri Sanat Tarihi metodolojisi içerisinde ele alınmıştır. Mezar taşı tipolojisi olarak çeşitliliğin sınırlı olduğu mezarlıkta süslemede kompozisyonların zenginliği ve bölgeye göre farklılığı ile önemli ayrın-tılar tespit edilmiştir. Yapraklı Mezarlığı’nda ayak taşlarının hemen hepsi bezenirken özellikle Batı Anadolu Bölgesi’ne özgü olarak bilinen Karadeniz Bölgesi’nde pek işlenmeyen cami tasvirli bir ayak taşı bulunmuştur. Kompozisyonda cami, minaresi son cemaat yeri ve önünde şadırvan veya türbe gibi mimari yapılar topluluğu içinde tasvir edilmiştir. Osmanlı Türkçesi ve Cumhuriyet Dönemi’ne ait günümüz Türkçesi ile yazılan kitabelerde ve içeriğinde değişen farklı-lıklar ile bir örnekte “Tanrı” lafzı olarak şahide de ilginç bir detay kaydedilmiştir. Mezarlıkta çok kaliteli işçilik ve malzemeden üretilen eserden başlayarak diğer mezar taşı yapma geleneğini sürdüren sade örnekler olarak eserlerde kronolojik biçimde değişimin izlenebilmesi açısından da önemlidir. Mezarlıkta incelenen on iki örnek biçim-form ve süsleme açısından detaylıca ele alınırken eserlerin özellikle Türk mezar taşı geleneği ve bölge kültürü içerisindeki yerleri belirlenmeye çalışılmıştır.
El optimismo y la procrastinación académica en los estudiantes universitarios
Authors: Chaquinga Erika , Mejía Rubio Andrea del Rocío
Published: July 2023

La vida universitaria implica desafíos y cambios que requieren habilidades adaptativas y recursos positivos. Los estudiantes optimistas suelen experimentar niveles más bajos de estrés, cansancio emocional y depresión, sin embargo, la procrastinación académica, se caracteriza por posponer tareas importantes, puede afectar el rendimiento académico y el bienestar de los estudiantes. Por lo tanto, el objetivo principal de este estudio fue determinar la relación entre el optimismo y la procrastinación académica en estudiantes universitarios. Para abordar esta investigación, se utilizó un enfoque cuantitativo de tipo descriptivo, correlacional y comparativo, empleando un diseño no experimental de corte transversal. La muestra consistió en 357 estudiantes universitarios de una Institución de Educación Superior de la ciudad de Ambato, con edades comprendidas entre los 18 y los 30 años. Se utilizó un método de muestreo no probabilístico por conveniencia para seleccionar a los participantes. Los instrumentos utilizados en este estudio incluyeron el Life Orientation Test Revised (Lot-R) (Scheier et al., 1994), la Escala de Procrastinación Académica (Busko, 1998) y un cuestionario sociodemográfico. Los resultados obtenidos revelaron una correlación inversa leve entre la postergación académica y el optimismo (Rho=-0.301, p<0.01). Además, se encontró una relación directa entre la autorregulación académica y el optimismo (Rho=0.345, p<0.01). No se encontraron diferencias significativas en cuanto al nivel de optimismo en función del sexo de los participantes (t (257) =1.33, p>0.05). Se concluye que los estudiantes universitarios que presentan mayores niveles de procrastinación académica tienden a tener niveles más bajos de optimismo.
Increasing Trend of Silver Nanoparticles as Antibacterial and Anticancer Agent
Authors: Ur Rehman Khan Attique , Adnan Muhammad , Begum Shaheen , Nazir Ruqia , Mussarat Sakina
Published: July 2023

Silver nanoparticles (AgNPs) synthesis from plants that already have been reported for medicinal purposes demonstrated better efficacy for curing diseases. Recently, a number of researches have been reported where AgNPs act as promising antibacterial and anticancer agent. Biosynthesized silver nanoparticles (AgNPs) are a type of environmentally friendly, cost-effective, and biocompatible substance that has gotten a lot of attention in treatment of cancer and inhibition of pathogenic microbes. In this chapter, a comprehensive report on the recent development of AgNPs as nanomedicine synthesized from plant extracts. The role and mechanism of AgNPs as antibacterial and anticancer agent was reported that leads towards development of targeted nannomedicines to treat infectious diseases and world most challenging disease like cancer. Reported literature give imminence importance of AgNPs and demonstrated more potency to treat cancer and bacterial infections.
The Effects of Transcranial ‎Direct Current Stimulation Over the Dorsolateral Prefrontal Cortex ‎on Cognitive Dysfunction in Alzheimer’s Disease: A Narrative Review
Authors: Rahimi Shourmasti Fatemeh , Khodamoradi Mehdi , Seyedhosseini Tamijani Seyedeh Masoumeh , Rafaiee Raheleh , Carvalho de Vasconcelos Carlos Augusto , Mohammadi Hiwa , Niknamfar Saba , Ghazvini Hamed
Published: July 2023

Context: Patients with mild cognitive impairment (MCI) and Alzheimer’s disease (AD) are more likely to suffer from cognitive dysfunction due to dementia. Transcranial direct current stimulation (tDCS) as a non-invasive treatment strategy has been used as an efficient strategy to improve cognitive function. Evidence Acquisition: Several studies investigating tDCS over the dorsolateral prefrontal cortex (dlPFC) were reviewed. Results: Most of these studies have targeted the left dlPFC, indicating that tDCS over the dlPFC can improve cognitive function, such as memory, visual recognition, attention, decision-making, and cognitive decline. However, there are still many unanswered questions about the effect of tDCS over the dlPFC on the connectivity of this brain region as a key node for cognitive function. Meanwhile, further research should be conducted to elucidate the effects of tDCS over the dlPFC on brain connectivity and AD biomarkers. In addition, more investigations should be conducted to identify the exact mechanisms affecting dlPFC stimulation on cognitive dysfunction in AD patients. Conclusions: Based on the results, tDCS over the DlPFC could improve cognitive function in AD patients.
The Significant Effects of Agricultural Systems on The Environment
Authors: Kaleem Ullah Muhammad , Shabir Sana
Published: July 2023

The sustainability of our world and the ecological balance are significantly shaped by agricultural systems. The main environmental implications of agricultural practices are highlighted in this research with an emphasis on both the detrimental effects and proposed remedies to lessen these effects. By supplying food, fiber, and different raw materials, agricultural systems are essential for maintaining human populations. These systems, though, have the potential to have a significant negative or positive impact on the environment. An overview of the main environmental impacts of agricultural systems is given in this research First, agricultural systems play a significant role in the production of greenhouse gases. The release of carbon dioxide (CO2), methane (CH4), and element oxide (N2O), all of which are powerful greenhouse gases that contribute to climate change, is influenced using synthetic fertilizers, intensive livestock production, and changes in land use. Second, agricultural practices have an impact on water resources. The overuse of irrigation water can cause groundwater aquifers to be depleted and rivers and lakes to dry up. Additionally, the fertilizer and pesticide-contaminated runoff from agricultural fields can contaminate water sources, leading to eutrophication and harming aquatic ecosystems. Adopting sustainable agricultural practices is necessary to meet rising food demands while reducing adverse effects. These methods include organic farming, agroforestry, precision agriculture, and improved water management strategies. By putting such practices into practice, one can encourage a more resilient and sustainable food production system while also reducing the negative environmental effects of agriculture.
On the Nature of Elasticity Function: An Investigation and a Kernel Estimation
Authors: Agbokou Komi
Published: July 2023

In economics, we know the law of demand: a higher price will lead to a lower quantity demanded. The question is to know how much lower the quantity demanded will be. Similarly, the law of supply shows that a higher price will lead to a higher quantity supplied. Another question is to know how much higher. To find answers to these questions which are critically important in the real world, we need the concept of elasticity. Elasticity is an economics concept that measures the responsiveness of one variable to changes in another variable. Elasticity is a function

e

x

that can be built from an arbitrary function

y
=
g

x

. Elasticity at a certain point is usually calculated as

e

x

=

d
y
/
d
x

x
/
y

. Elasticity can be expressed in many forms. An interesting form, from an economic point of view, is the ratio between the derivative of the logarithm of the distribution function with respect to the logarithm of the point

x

, which is developed in this article. The aim of this article is to study the direction of variation of this elasticity function and to construct a nonparametric estimator because the estimators that have been constructed so far are parametric estimators and admit many deficiencies in practice. And finally, we study the strong consistency of the said estimator. A numerical study was carried out to verify the adequacy of the theory.
Grupo Escolar Senador Correia (1912-1930): um estudo sobre cultura escolar
Authors: Solomon Silmara , Weber Maria Julieta
Published: July 2023

O artigo trata do processo de formação da cultura escolar no Grupo Escolar Senador Correia em Ponta Grossa-PR, no período de 1912 a 1930. A partir da pesquisa documental, perceberam-se elementos de uma cultura escolar em formação, mediante regras e normas de comportamentos que norteavam ações escolares por meio da organização de tempos e espaços, de forma a considerar também aspectos da cultura material escolar. Evidenciaram-se elementos como o silêncio, o tempo, a ordem e a conduta do professor enquanto representativos de heranças culturais inerentes ao contexto educacional republicano, em que se almejava um redimensionamento para a instrução pública a partir da idealização de modelos de escola primária no Brasil.
Approach to end-to-end testing of the application for managing the configuration of enterprise virtual infrastructure
Authors: Geraskin Evgeny Vadimovich , Voinov Nikita Vladimirovich
Published: July 2023

The article is devoted to end-to-end testing of the application for managing the configuration of enterprise virtual infrastructure. The main idea is to develop a software framework to create and perform end-to-end tests written in Python. The approach involves a comprehensive evaluation of the system from the user interface to the database. The testing process is performed in a continuous integration environment, which enables the team to test the system continually as new code is added. The testing process also includes the use of automated tests written in Python. The automated tests allow for faster and more reliable testing and enable the team to test the system across multiple platforms and configurations. The approach also includes the use of virtual environments to simulate the production environment. This enables the team to identify potential issues that may arise in the production environment and to test the system's performance under various conditions.
Применение локального разрывного метода Галеркина к решению квазигазодинамической системы уравнений
Authors: Шильников Евгений Владимирович , Shilnikov Evgenii Vladimirovich , Хайталиев Исматоло Рамазанович , Khaytaliev Ismatolo Ramazanovich
Published: July 2023

Рассматривается решение квазигазодинамической (КГД) системы уравнений локальным разрывным методом Галеркина (ЛРГ). Решаются одномерные задачи Римана о распаде разрыва с известными точными решениями. В решениях задач присутствуют сильные разрывы. Поэтому для обеспечения монотонности решения, полученного ЛРГ методом, введены так называемые ограничители наклона, или лимитеры. Был выбран «моментный» лимитер, сохраняющий как можно более высокий порядок. Проведена модификация лимитера для сглаживания осцилляций на участках постоянства решения.
Pembelajaran Langsung Berbasis Asessment For Learning (Afl) Sebagai Alternatif Model Pembelajaran Matematika
Authors: Mahfudy Sofyan
Published: July 2023

Abstrak— Pembelajaran langsung banyak digunakan guru matematika dalam prosespembelajaran. Namun demikian, pembelajaran langsung dianggap sebagai pembelajarankonvensional yang kurang efektif membantu pencapaian hasil belajar matematika siswa.Padahal besar kemungkinan suatu pembelajaran akan lebih efektif jika model tersebutdimodifikasi dengan teori pembelajaran tertentu. Penelitian ini bertujuan untuk mengetahuiefektifitas pembelajaran langsung berbasis assessment for learning (AfL) pada pembelajaranmatematika melalui eksperimen semu. Kelompok eksperimen 1 terdiri dari 3 kelas (sebanyak104 siswa) yang diberi perlakuan dengan pembelajaran langsung berbasis AfL dan kelompokeksperimen 2 terdiri dari 3 kelas (sebanyak 107 siswa) yang diberi perlakuan denganpembelajaran kontekstual. Metode pengumpulan data dalam penelitian ini adalahdokumentasi dan tes. Teknik analisis data yang digunakan adalah uji-t dengan sebelumnyadilakukan uji prasyarat analisis yaitu uji normalitas dengan uji Lilliefors dan uji homogenitasdengan uji Barlett. Hasil penelitian menunjukkan bahwa pembelajaran langsung berbasis AfLsama baiknya terhadap hasil belajar matematika siswa. Di sisi lain, banyak hasil penelitianmenunjukkan pembelajaran kontekstual memberikan hasil positif terhadap hasil belajarmatematika siswa. Dengan demikian pembelajaran langsung berbasis AfL efektif terhadappencapaian hasil belajar matematika siswa. Guru dapat merancang alternatif modelpembelajaran matematika dengan memodifikasi model pembelajaran langsung melaluioptimalisasi peran penilaian dalam proses pembelajaran.
Culture of Hoffa fat pad mesenchymal stem/stromal cells on microcarrier suspension in vertical wheel bioreactor for extracellular vesicle production
Authors: Otahal Alexander , Kramer Karina , Neubauer Markus , Lacza Zsombor , Nehrer Stefan , De Luna Andrea
Published: July 2023

Background
Mesenchymal stromal cells (MSCs) are increasingly employed in regenerative medicine approaches for their immunomodulatory and anti-inflammatory properties, which are encoded in their secretome including extracellular vesicles (EVs). The Hoffa fat pad (HFP) located harbours MSCs that could assist in tissue homeostasis in osteoarthritic joints. Intraarticular injection therapies based on blood products could modulate the populations of released HFP-MSC-EVs in a quantitative manner.
Methods
To obtain amounts of HFP-MSC-derived EVs that allow pre-clinical evaluation, suitable EV production systems need to be developed. This work investigates the release of EVs from primary HFP-MSCs cultivated in a 3D environment using microcarrier suspension culture in a vertical wheel bioreactor in comparison to conventional 2D culture. To simulate an intraarticular blood product therapy, cultures were treated with citrate-anticoagulated platelet-rich plasma (CPRP) or hyperacute serum (hypACT) before EV collection. HFP-MSC-EVs are enriched via ultrafiltration and characterised via Western Blot, nanoparticle tracking analysis in scatter as well as fluorescence mode.
Results
Blood product supplementation elevated metabolic activity as determined via XTT assay over the course of 14 days. 3D culture resulted in a roughly 100-fold EV yield compared to 2D culture and elevated number of EVs released per cell. Total protein content correlated with the EV concentration. While typical EV marker proteins such as CD9, CD63 or Alix were detected in total protein extracts, CD9 and CD73 colocalised on individual EVs highlighting their cell origin. The type of blood product treatment did not affect the size or concentration of EVs obtained from HFP-MSCs.
Conclusions
HFP-MSCs proliferate in presence of human blood products indicating that animal serum in culture media can be avoided in the future. The culture of HFP-MSCs in the employed bioreactor was successfully used to generate quantities of EVs that could allow evaluation of HFP-MSC-EV-mediated effects in pre-clinical settings.
Effectiveness of Virtual Training in the Post-Pandemic Period Using the Kirkpatrick Model
Authors: Suraj Neethu , N Abhishek
Published: July 2023

Teaching and training through online tools were used by most of the (HEIs) Higher Education Institute worldwide during covid-19 to cater to the needs of students who stay far away from universities/colleges. After the pandemic, the virtual model of education and training became a trend. The students and teachers are also more used to this trend and which is giving more opportunities to both learners and instructors. One of the notable benefits of virtual teaching and learning platform is that it provides a flexible environment to gain knowledge, skills, and attitude simultaneously along with formal off-line education. This directly influences the employability of outgoing UG and PG students. In this paper, an attempt has been made to assess the perceived effectiveness of virtual training and education among outgoing graduates under the Kirkpatrick model.
The Relationshıp Between Ghrelin And Iron Metabolism In Beta Thassemia Major Patients
Authors: SARKAYA Nihan Cansel , KURTOĞLU Ayşegül UĞUR , GÖÇER Mesut
Published: July 2023

Studies on HIF2α, hepcidin, and ferroportin molecules in beta thalassemia majör (β-TM) patients show that there are disorders in these pathways. In recent years, studies conducted in patients with iron deficiency anemia have investigated the relationship between ghrelin hormone and iron metabolism. In this study, we aimed to contribute to the etiopathogenesis of this disease by examining the changes in ghrelin hormone levels in patients with β-TM. 52 β-TM and 23 controls were included in our study. Cell blood counts, biochemical parameters, HIF2α, hepcidin and ghrelin levels were studied from blood samples taken from the volunteers. Serum HIF2α, hepcidin and ghrelin levels were measured by ELISA method. Erythrocyte indexs, serum total bilirubin, direct bilirubin, iron, unsaturated iron binding capacity, total iron binding capacity and ferritin levels showed significant differences between the two groups (p < 0.05). There was no significant difference between the two groups in serum HIF2α and hepcidin levels. When the patient group and healthy controls were compared, serum ghrelin levels were found to be significantly higher in the patient group (p < 0.05). There was a significant positive correlation between serum ghrelin and ferritin levels in the patient group (r = 0.401) (p < 0.05). It suggested that high ghrelin levels may have an important role in the regulation of impaired iron metabolism in patients with β-TM. The positive correlation between serum ghrelin levels and ferritin suggested that serum iron may have an important role in ghrelin synthesis, and that increased ghrelin levels may be a factor that increases ferritin synthesis.
Water-binding strength as regulator of extracellular-matrix mechanics enables detection of swelling-associated biophysical alterations using MRI
Authors: Kollert Matthias R. , Krämer Martin , Brisson Nicholas M. , Schemenz Victoria , Tsitsilonis Serafeim , Qazi Taimoor H. , Fratzl Peter , Vogel Viola , Reichenbach Jürgen R. , Duda Georg N.
Published: July 2023

Altered hygroscopic properties of the extracellular matrix (ECM), such as related to exudation, are characteristic for various pathologies including inflammation in injury, inherent swelling, or proteoglycan (PG) dysregulation. Mechanical properties of the ECM are key characteristics of various cell niches, capable of defining cell phenotype and fate, or of storing pathological information. Dehydration is known to alter ECM mechanics, but the role of the binding of water to the ECM remains unclear. Our data illustrate that the proportion of loosely to strongly bound water is a distinctive ECM property that regulates its mechanics and they suggest a crucial role of PGs for elastic and viscous characteristics. Osmolality and loosely bound water determine dynamic ECM properties. This understanding may pave the ground to diagnose related pathological tissue alterations non-invasively using combined MR T1 and T2* mapping. Eventually, the strength of water binding may be utilized as controlled cell-niche property to guide cell behavior.
Results of the DAPA-CKD trial and their impact on clinical practice
Authors: Bilchenko O.V.
Published: July 2023

Chronic kidney disease (CKD) is a growing medical and social problem in the world. Data from population base stu­dies demonstrate an increase in the prevalence of CKD and mortality. One of the causes is an increase in the number of patients with diabetes. Another reason is the limited ability to prevent the progression of the loss of kidney function. The first studies with dapagliflozin, such as DECLARE-TIMI 58 in patients with type 2 diabetes, showed a slowing of the progression of CKD to end-stage renal disease. The DAPA-CKD trial included patients with both type 2 diabetes and those without diabetes with an estimated glomerular filtration rate of 25 to 75 ml/min/1.73 m2 and albuminuria. The DAPA-CKD trial was terminated prematurely by independent monitors because of dapagliflozin overwhelming placebo. The primary endpoint, which included a sustained decrease in estimated glomerular filtration rate ≥ 50 %, end-stage renal disease, or death from renal or cardiovascular causes, was 39 % lower in the dapagliflozin group than in the placebo group. The effect of dapagliflozin on the primary endpoint was also similar among patients with dia­betic nephropathy, glomerulonephritis, ischemic or hypertensive CKD, and CKD of other or unknown cause. Also, the effect of dapagliflozin was the same regardless of concomitant cardiovascular diseases or chronic heart failure. All-cause mortality was 31 % lower among patients who received dapagliflozin at a dose of 10 mg. Dapagliflozin also significantly reduced the frequency of sudden decline in kidney function in CKD patients by 32 %. According to the results of a post-hoc analysis of the DAPA-CKD trial, compared to placebo, dapagliflozin reduced the frequency of hospitalizations due to cardiac causes, kidney and urinary tract diseases, metabolic and nutritional disorders, and oncological problems. This effect of dapagliflozin was independent of baseline type 2 diabetes. Based on the DAPA-CKD trial, dapagliflozin was approved by the Food and Drug Administration for use in reducing the risk of worsening kidney function, kidney failure, cardiovascular death, and heart failure hospitalization in adults with CKD.
AN INTELLIGENT LOAD BALANCING ALGORITHM FOR 5G-SATELLITE NETWORKS
Authors: Bello Mobolanle , Pillai Prashant , Sadiq Ali Safaa
Published: July 2023

Cellular networks are projected to deal with an immense rise in data
traffic, as well as an enormous and diverse device, plus advanced use
cases, in the nearest future; hence, future 5G networks are being
developed to consist of not only 5G but also different RATs integrated.
In addition to 5G, the user’s device (UD) will be able to connect to the
network via LTE, WiMAX, WiFi, Satellite, and other technologies. On the
other hand, Satellite has been suggested as a preferred network to
support 5G use cases. However, achieving load balancing is essential to
guarantee an equal amount of traffic distributed between different RATs
in a heterogeneous wireless network; this would enable optimal
utilisation of the radio resources and lower the likelihood of call
blocking/dropping. This study presented an artificial intelligent-based
application in heterogeneous wireless networks and proposed an Enhanced
Particles Optimization (EPSO) algorithm to solve the load balancing
problem in 5G-Satellite networks. The algorithm uses a call admission
control strategy to admit users into the network to ensure that users
are evenly distributed on the network. The proposed algorithm was
compared with Artificial Bee and Simulated Annealing algorithm using
three performance metrics: throughput, call blocking and fairness.
Finally, based on the experimental findings, results outcomes were
analysed and discussed.
Światowy towarowy rynek giełdowy; aktualny stan i tendencje w rozwoju
Authors: Jerzak Michał
Published: July 2023

W niniejszym artykule dokonano studium stanu światowego towarowego rynku giełdowego, a także wskazano na tendencje i kierunki rozwoju instytucji giełd towarowych na świecie. Instytucja ta podlegała znacznym przemianom wynikającym z rozwoju gospodarki i potrzeb uczestników rynku, co w konsekwencji doprowadziło do stworzenia globalnych elektronicznych platform handlowych. Giełda była zawsze miejscem generowania informacji rynkowej w zakresie poziomu cen i sytuacji na rynku surowców rolnych. Przede wszystkim jednak umożliwiała zarządzanie ryzykiem niekorzystnej zmiany ceny na rynku. Stwierdzono, że pomimo znaczącego rozwoju giełdowych rynków instrumentów finansowych, nominalny udział w obrotach operatorów giełdowych kontraktów na surowce rolnicze stale wzrasta.
OSMANLI DA KİMSESİZ DEFİNLERİ: XVIII. YÜZYILDA ÜSKÜDAR ÖRNEĞİ
Authors: Çetin Engin
Published: July 2023

Bu makale, Osmanlı’da kimsesizlerin nasıl defnedildiklerine
odaklanmaktadır. Dönem olarak XVIII. yüzyıl, mekân olarak ise Üsküdar
seçilmiştir. Araştırmanın temel kaynağını Cumhurbaşkanlığı Devlet
Arşivleri Başkanlığı Osmanlı Arşivi’nde yer alan belge ve defter serileri ile
kadı sicilleri teşkil etmektedir. Konuyla doğrudan ilgisinden dolayı öncelikle
kimsesiz mallarının tasarruf hakkına sahip olan beytülmâl birimlerinin
mahiyeti incelenmiştir. Ardından çalışmanın mekânsal kapsamını oluşturan
Üsküdar’a ait beytülmâl gelirlerinin hangi kurum ve kişiler tarafından
tasarruf edildiği tespit edilmiştir. Üsküdar’da beytülmâl gelirlerine ait
sınırların belirlenmesinin ardından bu hudutlar dahilinde kimsesiz
definlerinin nasıl icra edildiği konusu üzerinde durulmuştur. Bu çerçevede;
Üsküdar’ın yalnız olarak vefat eden insanları kimlerdi? Kimsesizler
öldüklerinde bunların cenazelerine kimler sahip çıkıyordu? Yılda ortalama
kaç kimsesiz vefat ediyordu? Bu insanların cenaze masrafları nasıl finanse
ediliyor ve kimler eliyle defnediliyorlardı? sorularına cevap aranmıştır. Tespit
edilebilen ölüm sayıları, vefat yerleri ve defin masraflarına ilişkin istatistik
veriler de çıkarılmıştır. Ayrıca göç ve salgın hastalıklar ile ölüm oranları
arasındaki ilişkiler de tespit edilmeye çalışılmıştır.
The Tradition of the Twins Mayang in Javanese Tribe Community Wedding in Sukamaju Village, Banggai District in the Perspective of Islamic Law
Authors: Malik Firdaus Abdul , S. Thahir Lukman , Akbar Muhammad
Published: July 2023

The twin mayang tradition is still being maintained and believed to be a way to bring goodness to the bride and groom and their families who carry out the wedding ceremony. The purpose of this research is to find out the form, process, value and philosophical meaning of the twin manyang tradition at Javanese weddings in the village of Suka Maju and its review in Islamic law. This research uses descriptive qualitative research with a cultural anthropological approach. This approach explains that a religion is not studied or researched by itself but is examined by linking it with other aspects. So that this research is not only to be able to know the law and its implementation but also to be able to understand the value and philosophical meaning in it so that it can benefit people's lives. Data was collected through observation and structured interviews and some supporting data in the form of files and other documents. The results of this study indicate that the twin mayang tradition in Javanese weddings is a tradition in which there are values, functions and benefits for the wedding couple. Twin mayang has a philosophical meaning and good messages and advice in running a household life, so that these values become the basis for continuing to preserve this tradition. In a review of Islamic law, the twin mayang tradition has Islamic values and principles. Islamic principles include the principles of monotheism, freedom, justice, mutual help and expediency. So thus the twin mayang tradition is a tradition that contains Islamic principles and is permissible as long as it does not conflict with Islamic law.
The Effect of Ethnoscience-Based CTL (Contextual Teaching and Learning) Model on Motivation and Physics Learning Outcomes of Students on the topic of Sound Waves
Authors: Munandar Rizky , Apsari Putu Ayas Ditha , Diarta Muhammad Hendri , Nurhasanah Nurhasanah , Arni Kurnia Julianti , Rahmat Solihin , Walihah Zahratul , Hikmawati Hikmawati
Published: July 2023

The purpose of this study was to determine the effect of using the ethnoscience-based CTL (contextual teaching and learning) model on student motivation and learning outcomes on the topic of sound waves in class XI MIPA 4 at SMA Negeri 2 Mataram. This research method uses a mixed method, with the sampling technique using the purposive sampling method. The research subjects were 26 students of class XI MIPA 4 SMA Negeri 2 Mataram. Quantitative data were analyzed using statistical analysis techniques through t-test by first doing normality test and homogeneity test. The results showed that the calculated t value was greater than the t table value, which was 9,203 which was greater than 2,068. Based on the results of the interviews showed an increase in the understanding of the concepts possessed by students. Thus, there is an effect of applying the Ethnoscience-based CTL model to students' motivation and learning outcomes
Feasibility analysis of automation for commercial construction project
Authors: Niranjana J Vasava  , Bankim R Joshi
Published: July 2023

The use of automation technology in the construction sector may cover a wide variety of operations, from the early design stage through on-site building construction, building maintenance, building control, and finally building disassembly or demolition. The extent of automation adoption varies greatly from one construction phase to the next. These days, as opposed to using automation for on-site operations, the use of automation in the construction sector has several important advantages, including increased worker safety at work, improved quality and cost-effectiveness above that of trained labor, and increased productivity and job efficiency. Research gaps need to be filled to address automated manufacturing process innovation. This study has been carried out most promising areas where automation is required with the help of scientific analysis through a questionnaire survey. This study identifies critical areas for improvement in automation in the work process in commercial construction projects. The respondents comprised site engineers, project managers, and supervisors of construction firms. The relative importance index is used in this study. Using the results of this study, categorized the primary variables for improvement like workers' safety alert procedures, reducing labor cost and construction delay, core test team under multiple projects, impropriate construction method, and better quality of life of the structure.
TÜRKİYE’DE İLLER ARASINDA BEŞ YAŞ ALTI ÇOCUK ÖLÜM HIZININ MEKÂNSAL ETKİLEŞİMİ: MEKÂNSAL PROBİT MODELLERİ
Authors: ÇAKIR Nazife Zeynep , ÇAĞLAYAN Ebru
Published: July 2023

Beş yaş altı çocuk ölüm hızı konusunda, Türkiye özellikle son yıllarda gösterdiği hızlı gelişmeye rağmen hala birçok ülkenin gerisinde bulunmaktadır. Nitekim, ülke genelinde iller arasında çocuk ölümleri hususunda büyük eşitsizliklerin mevcut olduğu bilinmektedir. İlgili sorunun önüne geçilmesinde, ölüm hızını etkileyen faktörlerin belirlenmesi oldukça önem arz etmektedir. Bu yönde yapılacak çalışmalar ile, ölüm hızının düşüşünde etkili olabilecek strateji ve politikaların geliştirilmesinin yolu açılacaktır. Bu doğrultuda çalışmanın amacını, 2019 yılında Türkiye’de beş yaş altı çocuk ölüm hızının iller arasındaki mekânsal etkileşiminin ve belirleyicilerinin mekânsal probit modelleri kullanarak analiz edilmesi oluşturmaktadır. Klasik probit modelinde mekânsal bağımlılık yapısının tespit edilmesinin ardından, Yaklaşık Olabilirlik tahmin yöntemi (Approximate Likelihood Estimation) kullanılarak, mekânsal gecikme (Spatial Autoregressive Model, SAR) ve mekânsal hata bağımlığına (Spatial Error Model, SEM) sahip probit modelleri tahmin edilmiştir. Tahminler neticesinde, kişi başında düşen gelir, merkezi devlet sağlık harcamaları ile ilköğretim ve ortaöğretim mezun oranlarının, beş yaş altı çocuk ölüm hızının üzerinde etkili olduğu ve ölüm hızını azalttığı belirlenmiştir.
Agents of Change: Feminist Literary Magazines, Editors, and the Politics of Cultural Production in Canada (1970–2000)
Authors: Markowicz Marcin
Published: July 2023

The following article is a concise introduction to the author’s doctoral research focused on Canadian feminist periodicals. The author introduces the basic tenets of his doctoral thesis and then shortly discusses his experience of working in and with the archives.