bluuebunny/crossref_metadata_2025 huggingface dataset:
Positioning of Automobile Brands in the Ukrainian Car Market in Anticipation of Its Post-War Recovery
Authors:   Luhansk Taras Shevchenko National University, Kolosov Andrii M. , Kucherenko Serhii K. ,   Oles Honchar Dnipro National University, Iakovenko Vladyslav S. ,   Oles Honchar Dnipro National University
Published: May 2023

Despite the fact that Russia's war against Ukraine, which led to a significant destruction of the Ukrainian car market, is still ongoing, there are urgent tasks to study the ways of post-war recovery of Ukraine, in particular, its car market. Against the background of a fall in the gross domestic product (GDP) of Ukraine for 2022 by no less than 40%, the car market of Ukraine decreased by the number of car sales even more, by 61.3%. In anticipation of the beginning of the post-war recovery of Ukraine, the question arises as to how the recovery of the Ukrainian car market will proceed – by simply reproducing previously achieved sales volumes, or by reforming the structure of the car market by individual car brands, countries of production, supply, etc. Expected data on the structure and volume of sales of cars by well-known car brands are of such great importance that they must be taken into account when creating the necessary conditions for the effective activity of people in the process of post-war recovery of Ukraine, which puts forward as an urgent task the monitoring of the state of positioning of car brands on the car market of Ukraine. It is shown that the line of automobile brands that developed in the pre-war years as a result of the interaction of factors of consumer preferences of Ukrainian car buyers can become a decisive factor in the structure of the car market in the process of its revival. According to the results of the conducted research, it is obvious that it is necessary to expect vehicles of the Toyota, Renault, Kia, ?koda, Hyundai and Volkswagen brands to be the leaders of the reviving car market, which in all cases will occupy the first places in terms of new car sales, including Volkswagen, Renault and ?koda remain leaders also in the market of secondary sales.
PEMBERIAN GULA PASIR DAN PUPUK GAVIOTA MENGGUNAKAN TEKNIK PERENDAMAN TANAMAN ANGGREK BULAN (Phalaenopsis hibrida) PADA FASE PEMBIBITAN
Authors: agustina Wahyu , Nuhayati Dewi Ratna , Sumarmi Sumarmi
Published: May 2023

Penelitian yang berjudul Pengaruh Pemberian Gula Pasir dan Pupuk Gaviota Menggunakan Teknik Perendaman Pada Tanaman Anggrek Bulan (phalaenopsis hibrida) Pada Fase Pembibitan dilaksanakan pada tanggal 17 Oktober 2022 sampai dengan tanggal 9 Januari 2023 di Kebun Green Leaves Orchid yang berada di Desa Sinoman Tempel, Kecamatan Sidorejo, Salatiga. Tujuan penelitian ini untuk mengetahui pengaruh pemberian Gula Pasir dan Pupuk Gaviota dengan dosis tertentu terhadap pertumbuhan tanaman anggrek bulan fase pembibitan. Penelitian menggunakan Rancangan Acak Lengkap (RAL) yang terdiri dari 2 faktor perlakuan dan 3 ulangan. Faktor pertama adalah pupuk Gaviota (P) dengan 3 taraf yaitu tanpa perlakuan 0 g/liter (P0), 15 g/liter) dan 25 g/liter (P2), faktor kedua yaitu Gula Pasir (S) dengan 3 taraf yaitu tanpa perlakuan 0 g/liter (S0), 2,5 g/liter (S1), 3,5 g/liter (S2). Parameter yang diamati meliputi jumlah akar, panjang akar (cm), jumlah daun baru, panjang daun (cm), lebar daun (cm), persentase tumbuh. Berdasarkan hasil penelitian, dan pembahasan maka dapat disimpulkan bahwa : kedua perlakuan memberikan respon atau berpengaruh terhadap perlakuan dosis pupuk Gaviota dan sukrosa.

Kata Kunci : Anggrek Bulan, Pupuk Gaviota, Gula Pasir
Calibration Measurements and Computational Models of Sensors Used in Autonomous Vehicles
Authors: Hajdu Csaba , Lakatos István
Published: May 2023

Unsuccessful overtaking maneuvers on two-lane rural roads are one of the major causes of road accidents in the 21st century. The complexity of this maneuver merits the adoption of a thorough method for developing a proposed assistance system to prevent accidents and consequently reduce the high number of fatalities and the associated economic costs. This study aims to introduce an intelligent Driver Overtaking Assistance System (DOAS) to assist drivers in performing overtaking maneuvers safely. The study also will introduce a method to assess the impact of all the influential variables related to the driver, vehicle, traffic, road, and the surrounding environment. In momentary driving situations, the DOAS uses the communicated information via Hello beacon messages (HBM) and a set of input sensors to measure the possibility of overtaking the preceding vehicle(s) proactively by considering whether the distance gap to the oncoming vehicle is sufficient for overtaking. Besides, the proposed system is a vehicle-based safety system based on the collection of contextual information from the driving vicinity to acquire all relevant information regarding the ambient driving environment and the vehicles involved in the overtaking. To do this, DOAS uses a Bayesian Network (BN) to model overtaking maneuvers. The work presented shows high accuracy and promising results in aiding safe overtaking, with significant improvements to overtaking maneuvers on two-lane rural roads.
DIGITAL CITIZEN PARTICIPATION OF COLLEGE STUDENTS: REALITY AND OPTIMIZATION PATH
Authors: Lu Haili , Fu Kefeng , Liu Xiaolin , Hu Wanshan
Published: May 2023

Digital citizenship participation refers to the utilization of digital technology by individuals or groups for the purpose of engaging in networked participatory behaviors. It involves four interconnected elements: individual, policy, political, and social participation. This study surveyed 446 college students from a private university in China and conducted interviews to explore their digital citizenship participation. It is found that college students' digital citizen participation is characterized by "strong individual interest-driven participation", "weak political concern", and "good digital citizen literacy". In order to improve college students' participation as digital citizens, it is crucial to cultivate digital literacy by applying the core competency framework of digital citizenship as a guiding principle. To create a sustainable path for students' participation, a four-pronged approach is proposed involving multi-stakeholders, namely society, government, schools, and teachers.
Keywords: college students, digital citizenship participation, multi-stakeholders, optimization path, participation characteristics
Eine Abhandlung zu den jungen Kasus des Wepsischen (Tikka, Toivo: Vepsän suffiksoituneet postpositiot. Kieliopillisiin sijoihin liittyvä suffiksoituminen)
Authors: Suhonen Seppo
Published: May 2023

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Sistem Informasi E-Learning Pada Amik Mahaputra Riau Berbasis Web
Authors: Muhammad  , Darmanta Sukrianto  , Dwi Oktarina  , Mi`rajul Rifqi  , Yuda Yuanda Pratama
Published: May 2023

AMIK Mahaputra Riau merupakan salah satu perguruan tinggi swasta yang berlokasi di provinsi Riau, AMIK Mahaputra Riau didirikan pada tahun 2002 dan memiliki satu program studi yaitu Manajemen Informatika tingkat Diploma III. Pada saat ini proses belajar mengajar secara daring atau online masih menggunakan beberapa sistem external seperti zoom meeting, google meet dan edmodo. Kemudian ketua prodi juga tidak dapat memantau kegiatan pembelajaran karena tidak adanya akses sebagai admin di dalam sistem external yang digunakan. Oleh karena itu penulis ingin memberikan solusi kepada pihak Kampus AMIK Mahaputra Riau, untuk membuat suatu aplikasi berbasis web dimana dapat mempermudah mahasiswa dan dosen dalam proses belajar mengajar serta dapat membantu ketua prodi dalam memonitoring kegiatan pembelajaran yang dilakukan oleh dosen dan mahasiswa. Penulis menggunakan metodologi pengembangan sistem, dan UML sebagai tools dalam tahap perancangan. Oleh karena itu penulis telah menyelesaikan membangun sistem informasi E-learning berbasis web agar meningkatkan efektifitas dan efisiensi mahasiswa dan dosen dalam proses belajar mengajar dan juga dapat mempermudah dosen dalam pemberian tugas dan materi, serta membantu ketua prodi dalam memonitorinng kegiatan pembelajaran
Combating Excessive Food Consumption Through Augmented Reality Packaging: An Explorative Study of Generation Z
Authors: Masnar Asriadi , Hidayah Firdania Octaviany , Ar Rachmah Isma , Nurbaya Nurbaya
Published: April 2023

In 2020, The Indonesian Food and Drug Authority published Front of Pack Nutrition Labelling to ease consumers decide their diet preferences. In line with this effort, digital campaigns can effectively educate society and reduce the high consumption of Sugar, Salt, and Fat (SSF)  in Indonesia. This research discusses the effectiveness of SSF consumption restriction messages delivered using Augmented Reality (AR) technology. This research uses a quantitative descriptive method. The data were collected from randomly selected 100 youngsters living in Jakarta, Bogor, Depok, Tangerang dan Bekasi (Jabodetabek) area and followed by the EPIC (Empathy, Persuasion, Impact, and Communication) model analysis. All four dimensions of EPIC fell on effective category within range 4.23-4.29 out of 5.8. These findings suggest that, in general, the advertisement for limiting the consumption of SSF with Augmented Reality media stands in the very effective category with a final score of 4.25 and represent that AR application in packaging can effectively be used for promoting or advertisising particular information.
A Study on the Factors Affecting the Hotel Selection of Congress Organizers and the Evaluation of Congress Services: The Case of Antalya
Authors: Aksu⃰ Professor Akın , Gogitidze Juliana
Published: April 2023

Growing international trade and technological progress taking place through the globalization process have increased the number of congress and conference events. Congress tourism has grown rapidly in Turkey over time. Antalya has an essential role in congress tourism. Within the scope of the study, the hotel selection factors, and the services provided to the travel agencies in congress organizations in Antalya were evaluated. For this purpose, travel agencies operating in Antalya were administered a questionnaire and the results were interpreted. The three most important factors affecting the hotel selection of congress organizers include hotel price, quick response to solve organizational problems, and hotel image. In addition to all these, opportunities, strengths, weaknesses, and threats were analyzed using SWOT analysis.
Analysis of Domestic Metaverse Education Research Trends From 2020 to 2022: Focusing on Topic Modeling
Authors:   The Korean Society of Culture and Convergence, Han Songlee , Kim Taejong
Published: May 2023

This study aimed to suggest an educational use for the Metaverse by analyzing the trends in domestic Metaverse education research after COVID-19. To supplement the limitations of traditional literature review, the LDA (Latent Dirichlet Allocation) technique was used among machine learning-based topic modeling analysis methods. As a result of the topic modeling analysis based on thesis data related to Metaverse education research, the following topics were derived: (1) Developing a Metaverse space and environment for another digital Earth, (2) The use of Metaverse in higher education and education in general, (3) Expansion of accessibility for an equal Metaverse world, utilization of welfare and religion, (4) Expanding Metaverse, content development using virtual and augmented reality technology, (5) Metaverse in elementary school, education in using virtual reality, and (6) Diversity of the Metaverse, expanding to nursing, art, and language fields. Based on the analysis results, academic implications of studies related to Metaverse education were suggested.
A Study on the Current Status of SW·AI-related Subjects in the Basic Liberal Arts Curriculum at Universities
Authors:   The Korean Society of Culture and Convergence, Jeon Jonghee
Published: May 2023

The purpose of this study is to explore the current status of SW and AI-related subjects in universities’ basic liberal arts curriculum and to present recent trends and discussions. SW and AI-related competencies are basic skills required for both majors and non-major, and are considered a kind of literacy. Each university has designated SW and AI-related courses as essential credits that students must basically complete and quickly reflected them in the basic liberal arts curriculum. In this study, related information was collected and organized based on the latest brochure and website information of domestic universities that can be confirmed as the final starting point from March to April 2023. As a result, a total number of 30 universities in Korea were presented for analysis of the study, and each university showed various domain names, subject names, and required credits according to unique characteristics and directions related to SW and AI. Through this study, it will be possible to understand the overall trends of SW and AI education in basic liberal arts education at universities and to identify educational implications and discussions.
A Study on John Cage’s Eastern Philosophical Thought Appearing in His Music: Focusing on <4' 33">
Authors:   The Korean Society of Culture and Convergence, Li Xiying , Kim hyuntai
Published: May 2023

In the context of the times to rebuild a better world after World War II, Eastern philosophy became the driving force for the Western world to seek new directions. John Cage was a leader in Western art after World War II, one of the most influential avant-garde composers in the United States in the 20th century. Composed under the influence of Eastern philosophy, <4' 33”> showed completely different characteristics from existing Western music in the structure and directing process, and brought innovation to the music industry through unprecedented bold attempts. This study is meaningful in examining how Eastern philosophical ideas such as Zen, Taoism, Indian philosophy, and  in <4' 33”> influenced the creation of this work, and exploring the intrinsic meaning John Cage intends to express through the Eastern philosophical ideas reflected in the work.
Kalkınma yardımları ve Türk dış politikası: Bir dönemselleştirme önerisi (2002-2022)
Authors: BELDER Ferit
Published: April 2023

Kalkınma yardımları özellikle yükselen güçler açısından uluslararası politikada bir etkinlik gösterisi ve statü arayışı bağlamında tartışılagelmektedir. Türkiye de 1990’lı yıllardan itibaren kalkınma yardımlarını dış politik öncelik ve tercihler bağlamında organize etmeye başlamıştır. Bu çalışma ise Türk dış politikasında 2000’li yıllardaki süreklilik ve değişim unsurlarını kalkınma yardımlarının miktar, coğrafi ve sektörel dağılım unsurları bağlamında evrimi ile ilişkilendirmekte ve dış politika dönemselleştirmesi önermektedir. İlk olarak dış politika- dış yardım ilişkisini yükselen güçler literatürüne referansla özetlemekte ve dış politika çalışmalarındaki dönemselleştirme konusunu ele almaktadır. Sonrasında ise farklı dış yardım pratikleri ile dış politika gündemindeki değişiklikler arasındaki paralellikleri tespit etmek amacıyla farklı dış yardım pratikleri tarihsel bir bağlam içerisinde ele almaktadır. Çalışma Türk dış yardımlarının değişik zamanlarda farklılaşan coğrafi, ekonomik, siyasi ve insani önceliklerinin Türk Dış Politikasının dönüşümü üzerine aydınlatıcı bir anlatı sunduğunu iddia etmektedir.
PERSONEL GÜÇLENDİRME VE BİREYSEL YARATICILIK İLİŞKİSİNDE LİDERLİK GÖREVLERİNİN ROLÜNÜN İNCELENMESİ
Authors: ALAY Hazal Koray , DEMİR Ferhat , GENÇ Serhat
Published: April 2023

Çalışanların iş yaşamındaki davranışları ve işleriyle olan ilişkileri pek çok değişkenden etkilenmektedir. Bu değişkenlerden en önemlilerinden biri de yöneticilerin liderlik davranışları ve işletmenin personel güçlendirme kültürüdür. Örgütler sürdürülebilir rekabet amacı için bilgiye ve güçlü insan kaynağına ihtiyaç duymaktadır. Bu çalışmanın birincil amacı küresel rekabet ortamında değişimin gücünden en iyi şekilde yararlanabilmek için bir gereklilik olan personel güçlendirme kavramı ile bireysel yaratıcılık ilişkisini ortaya koymaktır. Ayrıca personel güçlendirme ve bireysel yaratıcılık ilişkisinde liderlik görevlerinin rolünün incelenmesidir. Bu amaçla, kartopu örneklem belirleme yönteminden yararlanarak, İstanbul’da bir kamu kurumuna bağlı 300 çalışan ile ampirik bir araştırma gerçekleştirilmiştir. Araştırma bulguları IBM SPSS Statistics v.26 ve Hayes Process Macro v.4.1. istatistik programı yardımıyla analiz edilmiştir. Araştırmada veriler, frekans analizi, açıklayıcı faktör analizi, güvenilirlik analizi, pearson korelasyon analizi, çoklu regresyon analizi kullanılarak incelenmiştir. Yapılan analizler neticesinde personel güçlendirmenin bireysel yaratıcılık üzerindeki etkisi pozitif ve anlamlı olarak bulunmuştur. Personel güçlendirme ve bireysel yaratıcılık ilişkisinde liderlik görevlerinin aracı değişken olduğu tespit edilmiştir. Liderlik görevlerinin hem bireysel yaratıcılık hem de personel güçlendirme üzerinde etkili olduğu görülmüştür. Bu çalışma İstanbul Esenyurt Üniversitesi Etik Kurulu tarafından 31.05.2022 tarihli ve 2022/05-3 sayılı kararı ile etik açıdan uygun bulunmuştur.
SAĞLIK BİLİMLERİ FAKÜLTESİ ÖĞRENCİLERİNİN KİŞİSEL SAĞLIK VERİLERİNİN KAYIT VE KORUNMASINA İLİŞKİN TUTUMLARININ İNCELENMESİ
Authors: KARABAYIR Emine , KARACA DEDEOĞLU Ayşegül , KURŞUN Arzu
Published: April 2023

2010 yılında Anayasa ile güvence altına alınmış kişisel sağlık verileri, kişisel verilerin içinde önemli bir yere sahiptir. Bu verilerin korunamaması durumunda kişilerin dışlanma, ötekileştirilme ve damgalanma ihtimali bulunmaktadır. Bu çalışmada bir devlet üniversitesinin Sağlık Bilimleri Fakültesi’nde eğitim almakta olan ve sağlık sektöründe çalışmaya aday öğrencilerin kişisel sağlık verilerinin korunması konusunda tutumlarını belirlemek, kişisel sağlık verilerinin korunması konusunda bilgilerinin olup olmadığı anlamak ve demografik değişkenler bakımından farklılık olup olmadığını analiz etmek amaçlanmıştır. Sağlık Bilimleri Fakültesi’nde eğitim almakta olan hemşirelik, ebelik, çocuk gelişimi, fizyoterapi ve rehabilitasyon bölümündeki 2442 öğrenci bu çalışmanın evrenini oluşturmaktadır. Örneklem sayısının 332 kişi olması gerektiği belirlenmiş, araştırmada ise 641 gönüllü öğrenciye ulaşılmış, veriler yüz yüze anket tekniği ile toplanmıştır. Araştırmanın verileri SPSS 20.0 paket programı kullanılarak analiz edilmiştir. Veriler bağımsız örneklem T-testi ve tek yönlü ANOVA testi ile incelenmiştir. Araştırmaya katılan öğrencilerin kişisel sağlık verilerinin kayıt ve korunmasına ilişkin tutumları olumlu çıkmıştır (X̄3,59). Katılımcıların kişisel sağlık verilerinin korunmasına ilişkin farkındalıklarının olduğu, ancak yeterli düzeyde olmadığı söylenebilir. Sağlık personelinin ve sağlık eğitimi alan öğrencilerin, meslek yaşamında veya mesleğe geçmeden önce kişisel sağlık verilerinin kaydı ve korunması hakkındaki farkındalıklarının arttırılması gerekmektedir.
Pengaruh Latihan Tangan dengan Media Squishy terhadap Kekuatan Genggam pada Lansia
Authors: Susilawati Ela , Nadila Adis , Latief Kamaluddin
Published: April 2023

Proses penuaan menyebabkan penurunan fungsi musculoskeletal, menyebabkan lansia mengalami gangguan kekakuan otot dan sendi. Latihan tangan dengan media squishy terbukti mampu mencegah kehilangan kekuatan otot. Tujuan penelitian ini adalah mengetahui pengaruh latihan tangan dengan media squishy terhadap kekuatan genggam pada lansia. Jenis penelitian ini quasi eksperimental dengan desain pretest and posttest with control group. Jumlah sampel pada penelitian ini 60 lansia, terdiri dari 30 orang di kelompok intervensi dan 30 orang di kelompok kontrol. Alat yang digunakan untuk mengukur kekuatan genggam adalah hand dynamometer dan data yang didapatkan dianalisis dengan uji Wilcoxon. Hasil penelitian menunjukkan pada kelompok intervensi perempuan terdapat pengaruh yang siginifikan dimana nilai p = 0,004 < 0,05. Sementara itu, laki-laki di kelompok intervensi menunjukkan kekuatan genggam tangan kanan dengan nilai p = 0,209 > 0,05 yang artinya tidak ada pengaruh. Peneliti menyimpulkan tidak ada pengaruh latihan tangan dengan media squishy terhadap kekuatan genggam pada lansia. Penelitian selanjutnya diharapkan fokus pada tingkatan kekuatan genggam lansia agar bisa mengetahui perbandingan pengaruh latihan tangan dengan media squishy.
Faktor yang Memengaruhi Rendahnya Minat Penggunaan Metode Kontrasepsi Jangka Panjang Intrauterine Device di Kampung Keluarga Berencana
Authors: Sutrisminah Emi , Lisani Fifiana , Hudaya Isna
Published: April 2023

Minat masyarakat Indonesia terhadap Intrauterine Device (IUD) sebagai Metode Kontrasepsi Jangka Panjang (MKJP) relatif sedikit. Rendahnya minat terhadap IUD karena sebagian besar askeptor keluarga berencana (KB) kesulitan menentukan pilihan kontrasepsi. Faktor yang memengaruhi minat penggunaan IUD diantaranya pengetahuan, persepsi efek samping, dan dukungan suami. Penelitian ini bertujuan untuk mengetahui hubungan pengetahuan, persepsi efek samping dan dukungan suami terhadap rendahnya minat penggunaan MKJP IUD. Penelitian ini menggunakan metode analytical descriptive dan pendekatan cross-sectional. Populasi dalam penelitian ini sebanyak 393 askeptor KB dengan sampel sebanyak 76 askeptor KB. Instrumen penelitian adalah kuesioner. Analisis data menggunakan uji chi-square. Hasil penelitian menunjukkan hubungan signifikan antara persepsi efek samping terhadap rendahnya minat MKJP IUD dengan nilai p 0,000. Ada hubungan signifikan antara dukungan suami terhadap rendahnya minat penggunaan MKJP IUD dengan nilai p 0,005. Tidak ada hubungan signifikan antara pengetahun dan rendahnya minat penggunaan MKJP IUD dengan nilai p 0,143. Peneliti menyimpulkan bahwa pengetahuan cukup dan baik mengenai MKJP IUD tidak menjamin akseptor KB mempunyai minat menggunakan MKJP IUD. Persepsi mereka sangat memengaruhi pengambilan keputusan jenis kontrasepsi yang akan dipakai. Selain itu, dukungan suami sangat berdampak pada keputusan ibu dalam penggunaan MKJP.
Journaling Technique to Form Positive Behaviors in Adolescents
Authors: Veriza Ervon , Razi Pahrur , Roza Elvin , Triana Winda
Published: April 2023

Adolescence is an important period for the formation of health behaviors. However, data showed that more than 20% of adolescents in Indonesia ever carried out risky behaviors towards their health. The majority of risky behaviors include smoking, drinking alcohol, having premarital sex and drug abuse. The aim of the study was to determine the effectiveness of journaling technique interventions (writing journals) for the formation of positive behaviors of adolescents. The method used was quasi-experimental and a time series design for 3 months. The study was conducted from March to May 2022. The research subjects were grouped in one intervention group which consisted of 78 eleventh graders of senior high school. The results of the study showed that journaling technique can effectively help adolescents form more positive new behaviors with a p value < 0.001. More positive behaviors of adolescents influence on the decrease of risky behaviors. This research can be a reference for developing further research related to adolescent behavior problems.
Pijat Punggung dan Akupresur untuk Produksi ASI pada Ibu Postpartum Multipara: Quasi Eksperimen
Authors: Triwidayanti Triwidayanti , Ahmad Mardiana , Sinrang Andi Wardihan , Usman Andi Nilawati , Syamsuddin Saidah , Arsyad Muh Aryadi , Arsyad Nur Aliya
Published: April 2023

Pemberian ASI eksklusif sangat penting untuk perkembangan fisik, psikis dan intelektual. Namun demikian, cakupan pemberian ASI eksklusif 0-6 bulan masih rendah baik di tingkat lokal, nasional maupun global. Masalah yang sering dikeluhkan oleh ibu yaitu produksi ASI yang kurang ataupun tidak lancar dapat diatasi dengan pijat punggung dan akupresur. Penelitian ini bertujuan untuk menganalisis pengaruh pijat punggung dan akupresur terhadap produksi ASI pada ibu postpartum multipara. Penelitian ini menggunakan metode quasi experiment dengan rancangan posttest only. Jumlah sampel adalah 30 ibu postpartum multipara yang terbagi sama rata ke dalam kelompok pijat punggung dan kelompok akupresur. Semua intervensi dilakukan sekali sehari selama 7 hari dengan durasi 30 menit. Teknik pengambilan sampel menggunakan purposive sampling. Instrumen yang digunakan adalah lembar observasi, lembar SOP pijat punggung dan akupresur, dan kuesioner Postpartum Depression Screnning Scale (PDSS). Analisis yang digunakan yaitu uji independent t-test. Hasil penelitian menunjukkan rerata produksi ASI pada kelompok pijat punggung lebih rendah daripada kelompok akupresur dengan rata-rata produksi ASI setelah intervensi pada pijat punggung adalah 597,67 nm/dl dan akupresur adalah 687,33 nm/dl. Ada perbedaan antara pijat punggung dan akupresur terhadap peningkatan produksi ASI dengan nilai p 0,007. Pijat punggung dan akupresur dapat membantu ibu postpartum multipara yang mengalami kekurangan ASI dan bermanfaat untuk ibu yang mengalami masalah ASI di kelahiran anak yang sebelumnya.
The Clerical Policy of the Zemstvo Liberal Fronde of Chernihiv Province (1860-80s)
Authors: Kotelnytskyi Nazar
Published: May 2023

The purpose of the research paper is to clarify the basic components of the clerical policy of the zemstvo liberal party of Chernihiv province (hubernia), which was an integral and organic part of the ethno-confessional program of that trend of the liberation movement in the Russian Empire in the second half of the 19th century.

The scientific novelty of the study is in the fact that for the first time in historical science, an attempt is made to study the fundamental principles of the clerical policy of the zemstvo liberal party of Chernihiv province as a basis for the ethno-confessional program of the opposition aristocratic fronde.

Conclusions. The analysis of historical sources allows us to state the fact that the clerical policy of the zemstvo liberal fronde of Chernihiv province was an organic and integral part of the ethno-confessional programmatic of the opposition movement in the region. Relations between the Russian Orthodox Church and the zemstvo liberal party of the region in the second half of the 19th century underwent a certain evolution: from aspirations of partnership and practical attempts of cooperation to social competition, and later opposition to each other. The demarcation line of the mentioned metamorphoses was the revolutionary change in the domestic political course of the Russian Empire – from the era of modernizations of Alexander II to the era of political reaction of Alexander III. In our opinion, the failure of broad interaction of the church with the system of elected institutions of local self-government and, in particular, the zemstvo opposition of Chernihiv province, was one of the reasons for the systemic crisis of Russian absolutism at the end of the 19th century.
“INTELLIGENT TRAFFIC LIGHT” – IMPACT ON ROAD TRAFFIC SAFETY
Authors:   M.P. Shulgin State Road Research Institute State Enterprise, Kononenko Alla , Nahrebelna Liudmyla ,   M.P. Shulgin State Road Research Institute State Enterprise
Published: May 2023

Road safety and measures to ensure it are a priority area of our state’s activity in view of the content of Article 3 of the Constitution of Ukraine, where a person, his life and health, safety are recognized as the highest social value in Ukraine. Reducing the number of accidents, reducing the severity of the consequences of traffic accidents, and especially reducing road accidents with fatalities to a minimum is the main task of specialists who are engaged in improving road safety. Traffic lights are one of the main components of road infrastructure, they are an optical signaling device designed to regulate traffic vehicles and pedestrians on roads and railway crossings. It is this device that regulates the movement of vehicles and pedestrians on the roadway and helps to avoid traffic accidents. Today, the traffic light has entered our lives so much that it is even difficult to imagine how it is possible to regulate traffic flows and ensure the safety of pedestrians on the roads without it. Adaptive or so-called “smart traffic lights” are considered the most modern type of traffic light regulation. Smart traffic lights are modern equipment that allows you to measure the intensity of traffic at the intersection and quickly, in real time, change regulation programs to reduce traffic jams. Artificial intelligence itself analyzes flow parameters, time and date, intensity to improve traffic. It is worth noting that despite the obvious advantages, smart traffic lights will not be able to completely solve the problem of traffic jams, but they will help to partially solve the problem of traffic accidents and support the ecological situation, since the level of emissions of harmful substances into the atmosphere is reduced thanks to the smooth movement of traffic. Keywords: street and road network, traffic jam, smart traffic light, traffic flow.
In planta deglycosylation improves the SARS-CoV-2 neutralization activity of recombinant ACE2-Fc
Authors: Izadi Shiva , Vavra Ulrike , Melnik Stanislav , Grünwald-Gruber Clemens , Föderl-Höbenreich Esther , Sack Markus , Zatloukal Kurt , Glössl Josef , Stöger Eva , Mach Lukas , Castilho Alexandra , Strasser Richard
Published: May 2023

SARS-CoV-2 infects human cells via binding of the viral spike glycoprotein to its main cellular receptor, angiotensin-converting enzyme 2 (ACE2). The spike protein-ACE2 receptor interaction is therefore a major target for the development of therapeutic or prophylactic drugs to combat coronavirus infections. Various engineered soluble ACE2 variants (decoys) have been designed and shown to exhibit virus neutralization capacity in cell-based assays and in vivo models. Human ACE2 is heavily glycosylated and some of its glycans impair binding to the SARS-CoV-2 spike protein. Therefore, glycan-engineered recombinant soluble ACE2 variants might display enhanced virus-neutralization potencies. Here, we transiently co-expressed the extracellular domain of ACE2 fused to human Fc (ACE2-Fc) with a bacterial endoglycosidase in Nicotiana benthamiana to produce ACE2-Fc decorated with N-glycans consisting of single GlcNAc residues. The endoglycosidase was targeted to the Golgi apparatus with the intention to avoid any interference of glycan removal with concomitant ACE2-Fc protein folding and quality control in the endoplasmic reticulum. The in vivo deglycosylated ACE2-Fc carrying single GlcNAc residues displayed increased affinity to the receptor-binding domain (RBD) of SARS-CoV-2 as well as improved virus neutralization activity and thus is a promising drug candidate to block coronavirus infection.
The interaction between osteosarcoma and other cells in the bone microenvironment: From mechanism to clinical applications
Authors: Zeng Jin , Peng Yi , Wang Dong , Ayesha Khan , Chen Shijie
Published: May 2023

Osteosarcoma is a primary bone tumor with a high mortality rate. The event-free survival rate has not improved significantly in the past 30 years, which brings a heavy burden to patients and society. The high heterogeneity of osteosarcoma leads to the lack of specific targets and poor therapeutic effect. Tumor microenvironment is the focus of current research, and osteosarcoma is closely related to bone microenvironment. Many soluble factors and extracellular matrix secreted by many cells in the bone microenvironment have been shown to affect the occurrence, proliferation, invasion and metastasis of osteosarcoma through a variety of signaling pathways. Therefore, targeting other cells in the bone microenvironment may improve the prognosis of osteosarcoma. The mechanism by which osteosarcoma interacts with other cells in the bone microenvironment has been extensively investigated, but currently developed drugs targeting the bone microenvironment have poor efficacy. Therefore, we review the regulatory effects of major cells and physical and chemical properties in the bone microenvironment on osteosarcoma, focusing on their complex interactions, potential therapeutic strategies and clinical applications, to deepen our understanding of osteosarcoma and the bone microenvironment and provide reference for future treatment. Targeting other cells in the bone microenvironment may provide potential targets for the development of clinical drugs for osteosarcoma and may improve the prognosis of osteosarcoma.
Red blood cell distribution width and all-cause mortality in congestive heart failure patients: a retrospective cohort study based on the Mimic-III database
Authors: Ji Xuan , Ke Weiqi
Published: May 2023

Background

The red blood cell distribution width (RDW) is a metric that measures the variation in the size of red blood cells and is presented as the red blood cell volume coefficient of variation. Increased RDW levels are closely linked to an elevated risk of death from congestive heart failure (CHF) and might be a new risk marker for cardiovascular disease. This research sought to evaluate the possible link between RDW levels and all-cause mortality in CHF patients after controlling for other covariates.

Methods

The publicly accessible Mimic-III database served as the source of data for our research. We employed ICU admission scoring systems to gather information on each patient's demographical data, laboratory test results, comorbid conditions, vital signs, and scores. Among CHF patients, the link between baseline RDW levels and short-, medium-, and long-term all-cause mortality was evaluated by Cox proportional hazard analysis, smooth curve fitting, and Kaplan–Meier survival curves.

Results

In total, 4,955 participants were selected for the study with an average age of 72.3 ± 13.5 years (old) and with males accounting for 53.1%. The findings recorded from the fully adjusted Cox proportional hazard model showed that higher RDW was associated with a greater risk of 30-day, 90-day, 365-day, and 4-year all-cause death; the HRs and 95% confidence intervals were 1.11 (1.05, 1.16), 1.09 (1.04, 1.13), 1.10 (1.06, 1.14), and 1.10 (1.06, 1.13), respectively. The results were stable and reliable using subgroup analysis. Smooth curve fitting and the K-M survival curve method further validated our results.

Conclusion

The RDW levels had a u-shaped connection with 30-day mortality. The RDW level was linked to an elevated risk of short-, medium-, and long-term all-cause death among CHF patients.
Progression of aortic regurgitation following transcatheter closure of intracristal ventricular septal defects in children: a mid- to long-term follow-up study
Authors: Li Qiuman , Zhang Xu , Xu Yukai , Zhou Lingmei , Li Junjie , Zhang Zhiwei
Published: May 2023

Background

Early surgical closure is warranted to prevent aortic valve lesion and aortic regurgitation (AR) in intracristal ventricular septal defects (icVSDs). Experiences for transcatheter device closure of icVSDs are still limited. Our objectives are to investigate AR progression following transcatheter closure of icVSDs in children and to explore the risk factors for AR progression.

Methods and results

From January 2007 to December 2017, 50 children with icVSD who had successfully undergone transcatheter closure were enrolled. With 4.0 (interquartile range: 3.0–6.2) years of follow-up, AR progression was observed in 20% (10/50) of patients after icVSD occlusion, among which 16% (8/50) remained in mild level and 4% (2/50) evolved to moderate. None progressed to severe AR. Freedom from AR progression was 84.0%, 79.5%, and 79.5% at 1, 5, and 10 years of follow-up. A multivariate Cox proportional-hazards model revealed that x-ray exposure time [hazard ratio (HR): 1.11, 95% confidence interval (CI): 1.04–1.18, P = 0.001] and the ratio of pulmonary to systemic blood flows (HR: 3.38, 95% CI: 1.11–10.29, P = 0.032) were independent predictors for AR progression.

Conclusions

Our study suggested that transcatheter closure of icVSD in children is safe and feasible in mid- to long-term follow-up. No serious AR progression occurred after icVSD device closure. Greater left-to-right shunting and longer x-ray exposure time were both risk factors for AR progression.
Assisted reproductive technology and interactions between serum basal FSH/LH and ovarian sensitivity index
Authors: He Yumei , Liu Ling , Yao Fei , Sun Chenyu , Meng Muzi , Lan Yunzhu , Yin Chengliang , Sun Xingyu
Published: May 2023

Objectives

This study aimed to investigate whether the FSH (follicle-stimulating hormone)/LH (Luteinizing hormone) ratio correlates with ovarian response in a cross-sectional retrospective study of a population with normal levels of anti-Müllerian hormone (AMH).

Methods

This was a retrospective cross‐sectional study with data obtained from medical records from March 2019 to December 2019 at the reproductive center in the Affiliated Hospital of Southwest Medical University. The Spearmans correlation test evaluated correlations between Ovarian sensitivity index (OSI) and other parameters. The relationship between basal FSH/LH and ovarian response was analyzed using smoothed curve fitting to find the threshold or saturation point for the population with mean AMH level (1.1<AMH<6μg/L). The enrolled cases were divided into two groups according to AMH threshold. Cycle characteristics, cycle information and cycle outcomes were compared. The Mann-Whitney U test was used to compare different parameters between two groups separated by basal FSH/LH in the AMH normal group. Univariate logistic regression analysis and multivariate logistic regression analysis were performed to find the risk factor for OSI.

Results

A total of 428 patients were included in the study. A significant negative correlation was observed between OSI and age, FSH, basal FSH/LH, Gn total dose, and Gn total days, while a positive correlation was found with AMH, AFC, retrieved oocytes, and MII egg. In patients with AMH <1.1 ug/L, OSI values decreased as basal FSH/LH levels increased, while in patients with 1.1<AMH<6 ug/L, OSI values remained stable with increasing basal FSH/LH levels. Logistic regression analysis identified age, AMH, AFC, and basal FSH/LH as significant independent risk factors for OSI.

Conclusions

We conclude that increased basal FSH/LH in the AMH normal group reduces the ovarian response to exogenous Gn. Meanwhile, basal FSH/LH of 3.5 was found to be a useful diagnostic threshold for assessing ovarian response in people with normal AMH levels. OSI can be used as an indicator of ovarian response in ART treatment.
Fertility preservation in pediatric healthcare: a review
Authors: Chen Lin , Dong Zirui , Chen Xiaoyan
Published: May 2023

Survival rates for children and adolescents diagnosed with malignancy have been steadily increasing due to advances in oncology treatments. These treatments can have a toxic effect on the gonads. Currently, oocyte and sperm cryopreservation are recognized as well-established and successful strategies for fertility preservation for pubertal patients, while the use of gonadotropin-releasing hormone agonists for ovarian protection is controversial. For prepubertal girls, ovarian tissue cryopreservation is the sole option. However, the endocrinological and reproductive outcomes after ovarian tissue transplantation are highly heterogeneous. On the other hand, immature testicular tissue cryopreservation remains the only alternative for prepubertal boys, yet it is still experimental. Although there are several published guidelines for navigating fertility preservation for pediatric and adolescent patients as well as transgender populations, it is still restricted in clinical practice. This review aims to discuss the indications and clinical outcomes of fertility preservation. We also discuss the probably effective and efficient workflow to facilitate fertility preservation.
Investigation of low-level supergeostrophic wind and Ekman spiral as observed by a radar wind profiler in Beijing
Authors: Wang Songqiu , Guo Jianping , Xian Tian , Li Ning , Meng Deli , Li Hongjin , Cheng Wei
Published: May 2023

The supergeostrophic flow remains seldomly reported from an observational perspective. Here, 1 year record of radar wind profiler measurements and ERA-5 reanalysis collected at Beijing observatory station are used to characterize the vertical structures of supergeostrophic wind and Ekman spirals in the lower troposphere. It is found that supergeostrophic flow shows significant diurnal variation, with lowest frequency for the supergeostrophic wind forming during daytime under clear-sky conditions, largely due to strong turbulent mixing and friction in the daytime. By comparison, the planetary boundary layer at night is stably stratified, the supergeostrophic wind occurs more frequently due to friction-induced decoupling from the ground surface. Furthermore, the presence of cloud makes the supergeostrophic wind occur more often in the daytime. Also, the geostrophic wind deviation within 1 km of atmosphere is found to be more negatively associated with the difference between surface temperature and 2-m air temperature compared with that in the altitude range of 1–3 km, indicating that the supergeostrophic wind near ground surface is more subject to the influence of heat flux. Intriguingly, most of the vertical wind profiles in the PBL are found not to follow Ekman spiral under neutral atmospheric conditions. The supergeostrophic winds contribute significantly to the magnitude of Ekman spirals in the upper mixed layer. Overall, the profiles and evolution features of the supergeostrophic wind and Ekman spirals observed in the lower troposphere in Beijing are much complicated than expected. The findings lay a solid foundation for better elucidating the low-level atmospheric dynamics in Beijing.
Circulating extracellular particles from severe COVID-19 patients show altered profiling and innate lymphoid cell-modulating ability
Authors: Forte Dorian , Pellegrino Roberto Maria , Trabanelli Sara , Tonetti Tommaso , Ricci Francesca , Cenerenti Mara , Comai Giorgia , Tazzari Pierluigi , Lazzarotto Tiziana , Buratta Sandra , Urbanelli Lorena , Narimanfar Ghazal , Alabed Husam B. R. , Mecucci Cristina , La Manna Gaetano , Emiliani Carla , Jandus Camilla , Ranieri Vito Marco , Cavo Michele , Catani Lucia , Palandri Francesca
Published: May 2023

Introduction

Extracellular vesicles (EVs) and particles (EPs) represent reliable biomarkers for disease detection. Their role in the inflammatory microenvironment of severe COVID-19 patients is not well determined. Here, we characterized the immunophenotype, the lipidomic cargo and the functional activity of circulating EPs from severe COVID-19 patients (Co-19-EPs) and healthy controls (HC-EPs) correlating the data with the clinical parameters including the partial pressure of oxygen to fraction of inspired oxygen ratio (PaO2/FiO2) and the sequential organ failure assessment (SOFA) score.

Methods

Peripheral blood (PB) was collected from COVID-19 patients (n=10) and HC (n=10). EPs were purified from platelet-poor plasma by size exclusion chromatography (SEC) and ultrafiltration. Plasma cytokines and EPs were characterized by multiplex bead-based assay. Quantitative lipidomic profiling of EPs was performed by liquid chromatography/mass spectrometry combined with quadrupole time-of-flight (LC/MS Q-TOF). Innate lymphoid cells (ILC) were characterized by flow cytometry after co-cultures with HC-EPs or Co-19-EPs.

Results

We observed that EPs from severe COVID-19 patients: 1) display an altered surface signature as assessed by multiplex protein analysis; 2) are characterized by distinct lipidomic profiling; 3) show correlations between lipidomic profiling and disease aggressiveness scores; 4) fail to dampen type 2 innate lymphoid cells (ILC2) cytokine secretion. As a consequence, ILC2 from severe COVID-19 patients show a more activated phenotype due to the presence of Co-19-EPs.

Discussion

In summary, these data highlight that abnormal circulating EPs promote ILC2-driven inflammatory signals in severe COVID-19 patients and support further exploration to unravel the role of EPs (and EVs) in COVID-19 pathogenesis.
How to improve the outcomes of elderly acute myeloid leukemia patients through allogeneic hematopoietic stem cell transplantation
Authors: Jiang Shan , Yan Han , Lu Xuan , Wei Ruowen , Chen Haoran , Zhang Ao , Shi Wei , Xia Linghui
Published: May 2023

In recent years, with the gradual advancement of haploidentical transplantation technology, the availability of donors has increased significantly, along with the widespread use of reduced-intensity conditioning and the improvement of nursing techniques, giving more elderly acute myeloid leukemia (AML) patients the chance to receive allogeneic hematopoietic stem cell transplantation. We have summarized the classic and recently proposed pre-transplant assessment methods and assessed the various sources of donors, conditioning regimens, and post-transplant complication management based on the outcomes of large-scale clinical studies for elderly AML patients.
Cytokines induced memory-like NK cells engineered to express CD19 CAR exhibit enhanced responses against B cell malignancies
Authors: He Bailin , Mai Qiusui , Pang Yunyi , Deng Shikai , He Yi , Xue Rongtao , Xu Na , Zhou Hongsheng , Liu Xiaoli , Xuan Li , Li Chengyao , Liu Qifa
Published: May 2023

CD19 chimeric antigen receptor (CAR) engineered NK cells have been used for treating patients with relapsed and/or refractory B cell malignancies and show encouraging outcomes and safety profile. However, the poor persistence of NK cells remains a major challenge for CAR NK cell therapy. Memory-like NK cells (MLNK) induced by IL-12, IL-15, and IL-18 have shown enhanced and prolonged responses to tumor re-stimulation, making them an attractive candidate for adoptive cellular immunotherapy. Here, we show efficient and stable gene delivery of CD19 CAR to memory-like NK cells using retroviral vectors with transduction efficiency comparable to those achieved with conventional NK cells. Analysis of surface molecules revealed a distinct phenotypic profile in CAR engineered memory-like NK cells (CAR MLNK), as evidenced by increased expression of CD94 and downregulation of NKp30 as well as KIR2DL1. Compared to conventional CAR NK cells, CAR MLNK cells exhibited significantly increased IFN-γ production and degranulation in response to CD19+ target cells, resulting in enhanced cytotoxic activity against CD19+ leukemia cells and lymphoma cells. Furthermore, memory properties induced by IL-12/-15/-18 improved the in vivo persistence of CAR MLNK cells and significantly suppressed tumor growth in a exnograft mouse model of lymphoma, leading to prolonged survival of CD19+ tumor-bearing mouse. Altogether, our data indicate that CD19 CAR engineered memory-like NK cells exhibited superior persistence and antitumor activity against CD19+ tumors, which might be an attractive approach for treating patient with relapse or refractory B cell malignancies.