bluuebunny/crossref_metadata_2025 huggingface dataset:
Congenital Zika Virus Infection Impairs Corpus Callosum Development
Authors: Christoff Raissa Rilo , Quintanilha Jefferson H. , Ferreira Raiane Oliveira , Ferreira Jessica C. C. G. , Guimarães Daniel Menezes , Valério-Gomes Bruna , Higa Luiza M. , Rossi Átila D. , Bellio Maria , Tanuri Amilcar , Lent Roberto , Garcez Patricia Pestana
Published: November 2023

Congenital Zika syndrome (CZS) is a set of birth defects caused by Zika virus (ZIKV) infection during pregnancy. Microcephaly is its main feature, but other brain abnormalities are found in CZS patients, such as ventriculomegaly, brain calcifications, and dysgenesis of the corpus callosum. Many studies have focused on microcephaly, but it remains unknown how ZIKV infection leads to callosal malformation. To tackle this issue, we infected mouse embryos in utero with a Brazilian ZIKV isolate and found that they were born with a reduction in callosal area and density of callosal neurons. ZIKV infection also causes a density reduction in PH3+ cells, intermediate progenitor cells, and SATB2+ neurons. Moreover, axonal tracing revealed that callosal axons are reduced and misrouted. Also, ZIKV-infected cultures show a reduction in callosal axon length. GFAP labeling showed that an in utero infection compromises glial cells responsible for midline axon guidance. In sum, we showed that ZIKV infection impairs critical steps of corpus callosum formation by disrupting not only neurogenesis, but also axon guidance and growth across the midline.
Sex Differences in Serious Adverse Events Reported Following Booster Doses of COVID-19 Vaccination in Thailand: A Countrywide Nested Unmatched Case-Control Study
Authors: Janekrongtham Chawisar , Salazar Mariano , Doung-ngern Pawinee
Published: November 2023

A booster dose of a COVID-19 vaccine has been proven effective in restoring vaccine effectiveness and is currently recommended for use in some populations at risk of severe COVID-19 infection. Since sex differences in adverse events are significant in response to the vaccines, the safety of booster selection must be studied to avoid serious adverse events (SAE), such as life-threatening diseases. First, this study aimed to identify sex differences in SAE incidences using a prospective cohort design. Second, a nested unmatched case-control study was used to identify factors associated with reported SAE within 30 days after the booster shot. Multivariable logistic regression indicated the adjusted odds ratio by accounting for host and vaccine variables, thus, policy effects. The findings confirmed that SAE was rare and that age-sex-dominated disease classifications differed. Specific to SAE following the booster dose, we found that females aged 12–40 had a higher risk of being reported with SAE than males of the same age, while males over 50 had a higher risk than females. Other risk factors identified were the presence of metabolic syndrome and the use of certain vaccine brands. Mechanisms could be explained by individual host responses rather than the vaccines’ direct effect. Therefore, SAE could be preventable by age-sex-specific vaccine selection, post-vaccination precautions, and early symptom detection. Future vaccine development should aim to limit host-specific reactogenicity for safety concerns.
A Practical Guide to Pilot Testing Community-Based Vaccination Coverage Surveys
Authors: Rhoda Dale A. , Cutts Felicity T. , Agócs Mary , Brustrom Jennifer , Trimner Mary Kay , Clary Caitlin B. , Clark Kathleen , Koffi David , Manibaruta Jean Claude , Sowe Alieu , Gunnala Rajni , Ogbuanu Ikechukwu U. , Gacic-Dobo Marta , Danovaro-Holliday M. Carolina
Published: November 2023

Pilot testing is crucial when preparing any community-based vaccination coverage survey. In this paper, we use the term pilot test to mean informative work conducted before a survey protocol has been finalized for the purpose of guiding decisions about how the work will be conducted. We summarize findings from seven pilot tests and provide practical guidance for piloting similar studies. We selected these particular pilots because they are excellent models of preliminary efforts that informed the refinement of data collection protocols and instruments. We recommend survey coordinators devote time and budget to identify aspects of the protocol where testing could mitigate project risk and ensure timely assessment yields, credible estimates of vaccination coverage and related indicators. We list specific items that may benefit from pilot work and provide guidance on how to prioritize what to pilot test when resources are limited.
SARS-CoV-2 Vaccine Effectiveness in Hospitalized Patients: A Multicenter Test-Negative Case–Control Study
Authors: Thirión-Romero Ireri , Fernández-Plata Rosario , Pérez-Kawabe Midori , Meza-Meneses Patricia A. , Castro-Fuentes Carlos Alberto , Rivera-Martínez Norma E. , Barrón-Palma Eira Valeria , Sánchez-Sandoval Ana Laura , Cornejo-Juárez Patricia , Sepúlveda-Delgado Jesús , Torres-Erazo Darwin Stalin , Pérez-Padilla José Rogelio
Published: November 2023

Background: Phase III clinical trials have documented the efficacy of the SARS-CoV-2 vaccines in preventing symptomatic COVID-19. Nonetheless, it is imperative to continue analyzing the clinical response to different vaccines in real-life studies. Our objective was to evaluate the effectiveness of five different vaccines in hospitalized patients with COVID-19 during the third COVID-19 outbreak in Mexico dominated by the Delta variant. Methods: A test-negative case–control study was performed in nine tertiary-care hospitals for COVID-19. We estimated odds ratios (OR) adjusted by variables related a priori with the likelihood of SARS-CoV-2 infection and its severity. Results: We studied 761 subjects, 371 cases, and 390 controls with a mean age of 53 years (SD, 17 years). Overall, 51% had a complete vaccination scheme, and an incomplete scheme (one dose from a scheme of two), 14%. After adjustment for age, gender, obesity, and diabetes mellitus, we found that the effectiveness of avoiding a SARS-CoV-2 infection when hospitalized with at least one vaccination dose was 71% (OR 0.29, 95% CI 0.19–0.45), that of an incomplete vaccination scheme, 67% (OR 0.33, 95% CI 0.18–0.62), and that of any complete vaccination scheme, 73% (OR 0.27, 95% CI 0.17–0.43). Conclusions: The SARS-CoV-2 vaccination program showed effectiveness in preventing SARS-CoV-2 infection in hospitalized patients during a Delta variant outbreak.
From Renewable Biomass to Water Purification Systems: Oil Palm Empty Fruit Bunch as Bio-Adsorbent for Domestic Wastewater Remediation and Methylene Blue Removal
Authors: Almeida-Naranjo Cristina E. , Gallegos Elvia , Domínguez Elizabeth , Gutiérrez Paola , Valle Vladimir , Aguilar Alex Darío , Debut Alexis , Vasco Catalina
Published: November 2023

Oil palm empty fruit bunch fibers (OPEFBF), in three size ranges (small: 250–450 µm, medium: 450–600 µm, large: 600–800 µm), were investigated as a filter-bed material in biofilters for the removal of organic matter and nutrients. After saturation, these fibers (post) were used in the removal of methylene blue through batch processes. The batch adsorption tests included optimizing the adsorbent dosage (0.5–32.0 g/L) and contact time (2.5–60.0 min). Experimental data were fitted to various kinetic/isotherm models. Instrumental characterization of both raw and post fibers was conducted. Post fibers underwent morphological/compositional changes due to the presence of microorganisms and their byproducts. Efficiencies reached up to 94% for chemical oxygen demand (COD), 88.4% for total nitrogen and 77.2% for total phosphorus. In batch adsorption, methylene blue removal exceeded 90%, underscoring the effectiveness of small raw OPEFBF and large post OPEFBF. Kinetic models indicated that raw OPEFBF better fit the pseudo-first-order model, while post OPEFBF better fit the pseudo-second-order model. Both types of OPEFBF showed a good fit with the Freundlich model (higher R2, lower χ2 and SSE). Particularly, large post OPEFBF stood out as the most efficient adsorbent, achieving a maximum adsorption capacity of 12.02 mg/g for methylene blue. Therefore, raw/post OPEFBF could be an alternative to remove contaminants from wastewater.
Sedimentary Characteristics and Internal Architecture of a Sandy Braided River: Insights from a Numerical Model
Authors: Guo Ying , Li Shaohua , He Faqi , Lei Tao
Published: November 2023

Sandy braided river deposits are widely observed in ancient stratigraphic records and modern sedimentary basins. Frequent channel migration shapes intricate internal architecture, while research on its influence on fine sedimentary architecture remains limited. This study utilizes DELFT3D to simulate and analyze the sedimentary processes and architecture of the channel bar in a sandy braided river. The results show that: (1) The channel bar consists of downstream accretion (DA), lateral accretion (LA), and aggradational accretion (AA). (2) Channel bars can be divided into three types: unit bars, compound bars, and complex compound bars. Unit bars are lobate-shaped and consist of multiple accretions, including DA in the core, AA layered above, and LA deposited on the sides. Compound bars result from the migration and amalgamation of multiple unit bars, characterized by a greater number of accretions. Compound bars can further be classified as DA-dominated or LA-dominated, depending on the dominant accretion type. Complex compound bars form from the merging of multiple unit bars and compound bars. In this paper, insights from a braided river on its sedimentary processes and evolution may help to improve river management and water resources research. The in-depth understanding of sedimentary architecture on channel bars can be utilized for detailed subsurface oil and gas reservoir characterization.
Seasonal Controls of Seawater CO2 Systems in Subtropical Coral Reefs: A Case Study from the Eastern Coast of Shenzhen, China
Authors: Yang Bo , Zhang Zhuo , Xie Ziqiang , Chen Bogui , Zheng Huina , Liao Baolin , Zhou Jin , Xiao Baohua
Published: November 2023

In situ field investigations coupled with coral culture experiments were carried out in the coral reef waters of the eastern coast of Shenzhen, Da’ao Bay (DAB), Dalu Bay (DLB), and Yangmeikeng Sea Area (YMKSA) to study the dynamics of the carbon dioxide (CO2) system in seawater and its controlling factors. The results indicated that the CO2 parameters were highly variable over a range of spatiotemporal scales, forced by various physical and biochemical processes. Comprehensively, DAB acted as a sink for atmospheric CO2 with exchange flux of –1.51 ± 0.31 to 0.27 ± 0.50 mmol C m−2 d−1, while DLB and YMKSA acted as a CO2 source with exchange fluxes of –0.42 ± 0.36 to 1.69 ± 0.74 mmol C m−2 d−1 and –0.58 ± 0.48 to 1.69 ± 0.41 mmol C m−2 d−1, respectively. The biological process and mixing effect could be the most important factor for the seasonal variation in total alkalinity (TA). In terms of dissolved inorganic carbon (DIC), in addition to biological process and mixing, its seasonal variation was affected by air–sea exchange and coral metabolism to some extent. Different from the former, the other CO2 parameters, total scale pH (pHT), partial pressure of CO2 (pCO2), and aragonite saturation state (ΩA), were mainly controlled by a combination of the temperature change, biochemical processes, air–sea exchange, and coral metabolism, while water mixing has little effect on them. In addition, our results indicated that coral communities could significantly increase the DIC/TA ratio by reducing the TA concentration and increasing the DIC in the reef waters, which may promote the acidification of local seawater and need attention.
Low-Carbon Incentive Guidance Strategy for Electric Vehicle Agents Based on Carbon Emission Flow
Authors: Fu Huazhao , Zhao Yi , Chen Qichao , Ban Mingfei , Qian Xiaoyi , Sun Wenyao , Liu Yu , Xu Hang
Published: November 2023

The cleanliness of charging power determines whether electric vehicles can fully utilize their low-carbon properties. This paper, taking into account the impact of temperature on the energy consumption of electric vehicle air conditioning, uses the Monte Carlo algorithm to calculate the typical daily charging load of electric vehicle clusters in different seasons. Secondly, based on the Shapley value carbon responsibility allocation method, a reasonable range of carbon emission responsibilities for different electric vehicle agents is calculated, and a tiered carbon pricing method is proposed accordingly. Then, using carbon emission flow theory, we calculate the carbon emissions generated by the different agents’ charging amounts and corresponding carbon emission costs. Finally, a low-carbon incentive guidance model is constructed with the signal of tiered carbon prices and the goal of minimizing operating costs to re-optimize the charging load distribution of electric vehicles. Case studies showcase that the proposed method is effective in reducing power system carbon emissions and electric vehicle charging costs.
Pathogenetic and associative relationships between the parameters of periodontal health and bone mineral density in women living in a megalopolis
Authors: Grigorev S. S. , Sablina S. N. , Elovikova T. M. , Zakroeva A. G. , Krokhalev V. Ya. , Fominykh M. I. , Urgunaliev B. K. , Ivanova V. V.
Published: November 2023

Relevance. Osteoporosis and chronic periodontitis are serious issues of modern life. The hypothesis that these two diseases are associated is still open-ended and doesn’t allow setting the record straight for the lack of sufficient evidence.Purpose. The study aimed to detect the relationship between periodontal health parameters and mineral bone density characteristics in postmenopausal women.Material and methods. The study examined 109 female patients with diagnosed moderate chronic generalized periodontitis (К05.31). The participants formed two groups: the main group (76 women) and the control group (33 women). Dual-energy X-ray absorptiometry, FRAХ® and CCI assessed the mineral bone density and patients’ systemic health. Dental status was evaluated using the OHI-S, CAL, PPD, PMA, PI, and PBI. X-ray assessment was based on the Fuchs index for upper and lower jaws, and the mandibular cortical index (MCI) was evaluated by CBCT scans in Galaxis Galileos software (Sirona), Orthophos SL CBCT scanner. The data were statistically analysed using licensed STATISTICA 13.3 software. In descriptive statistics for variables, the median was quartiles corresponding to the 25th percentile and the 75th percentile. The Shapiro-Wilk test and χ2 (chi-square) evaluated the normality of variables.Results. Periodontal pocket depth (PPD) was 4.44 (4.30:4.20:4.50) in the main group. The cumulative change in the clinical attachment level (CAL) was 5.53 (5.50:5.40:5.80), which was significantly higher than the control group parameters (р < 0.001). Bone mineral density of L1-L4 vertebrae corresponded to osteopenia (g/cm2) -0.83 (-080: -0.78: -0.91), spine (Neck) Т-score was -1.70 (-1.7: -2.2: -2.0). In the patients of the control group, the CBCT did not show any signs of inf lammatory destruction, and the DXA test did not reveal any loss of bone mineral densit y.Conclusion. There are mean significant (less than 0.05) correlations between right femoral neck Т-scores and periodontal pocket depth parameters (R = -0.39) and between the same parameter and the clinical attachment level (CAL) (R = -0.37). A significantly high degree of negative correlation is between the spine Т-score of L1-L4 and PPD, correlation coefficient (R = -0.72).
Improving the Retailing Experience of the New Age Information-Seeking Consumers Using QR Code
Authors: Barve Dr. Manmeet , Maske Ms. Neelam , Naik Ms Shravani , Munj Ms Mrunalini
Published: November 2023

Shopping your apparels by scanning your friend's clothes sounds bizarre, however QR technology can make it possible. This paper intends to introduce the idea of how QR Codes of shoppable links can be printed on the tags of apparels and can be scanned by the wearer's social group to shop the product anywhere and anytime. The QR technology was developed by an engineer at Denso Wave, a company located in Aichi, Japan. It started as 1D Barcode then progressed to a 2D barcode and now we have multi-coloured, customisable and personalised QR Codes. This technology has a long history. Since QR codes have been around for more than a decade now there is already a considerable share of businesses and brands that have successfully started the use of QR code campaigns. However apparel marketing industry is taking longer than expected to catch up with QR code technology. Today, smartphones come with in-built QR Code Readers, hence it takes only a few seconds to scan the code that lends customers to the product's website. In Scannable marketing, QR Codes have a big future.
Biological control of weeds in Aotearoa / New Zealand: History, science and achievements to date
Authors: Matthews Jade K. , Fraser Diane L. , de Lange Peter J.
Published: November 2023

Aotearoa / New Zealand is the leading country globally in the use of biological control agents to combat introduced pest weed species. Here we review the history of biological control in Aotearoa / New Zealand, compile a list of current, self-introduced and accidentally introduced biocontrol agents, and list the agents currently under consideration for introduction to Aotearoa / New Zealand (accurate to 2021). We discuss the science and procedures in place for the safe introduction of a new biocontrol agent and discuss the public’s perception of biological control within Aotearoa / New Zealand. Since the 1920s there have been 79 control agents released; 68 of those species were deliberate introductions, eight self-introductions and three accidental introductions. Additionally, there have been eight reported occurrences of non-target-species attack by biological control agents in Aotearoa / New Zealand, all of which cause minor damage to their unintended hosts. Prior to their introduction to Aotearoa / New Zealand, potential biological control agents are required to undergo rigorous research and host-specificity testing to ensure that the agent does not pose a risk to indigenous taxa through non-target attack. This research is essential, as it ensures a precautionary approach is taken prior to introductions, which, in turn, provides the wider public with confidence in the validity of biocontrol agents as a means to manage weed species in Aotearoa / New Zealand.
“We are not all the same but that’s okay.” Creating understanding of pedagogical changes in early childhood practicum through collaboration
Authors: Perry Jo , Probine Sarah
Published: November 2023

This paper outlines research examining the impact of a reconceptualised approach to practicum for the newly reaccredited Bachelor of Education (Early Childhood Teaching) at Manukau Institute of Technology | Te Pūkenga. In alignment with the Teaching Council of Aotearoa New Zealand’s (2019) requirements for initial teacher education providers, which emphasise the need for new graduates to be able to clearly articulate their practice, the ECE team at MIT developed a new approach that situates the student teacher more strongly at the centre of the practicum. This research aimed to examine first how the Visiting Lecturers on the BEd (ECT) teaching team interpreted this new approach in their practice, and second to examine the process of negotiating shared understandings for the whole team. Finally, it aimed to understand the impact of these changes on student teachers’ learning and their ability to articulate their professional knowledge. The research took a sociocultural, ethnographic methodological approach. The Visiting Lecturers were invited to two focus-group conversations and the student teachers were invited to respond to an anonymous online survey. The findings from the focus groups revealed that the team have diverse understandings of their roles and how to approach the assessment of students’ practice. The need for further development of shared language and understandings surrounding this new approach was made apparent. Interestingly, whilst the focus groups revealed a need for further clarity, the student teachers’ survey responses revealed that this new approach has empowered and supported them to better understand the assessment of practice criteria and articulate their pedagogical decisions to others. The research is ongoing; however, the findings from 2022 demonstrate that making shifts in practice and developing new pedagogical approaches in collaborative contexts is a complex, tangled process that needs time to develop. The findings also show that, through repositioning the student at the centre of the practicum, students are much better equipped to take ownership for the development of their professional knowledge.
Learner engagement with where-to-next feedback in early tertiary studies
Authors: Wessels Antoinette , Kearns Nick , Robertson Craig
Published: November 2023

Learners on the New Zealand Diploma in Business are early tertiary learners and do not perform as well as it is believed that they should. In addition, there is a disparity between ethnicities and age groups. This study researched the use of where-to-next (WTN) feedback as a possible tool to address this disparity and prepare learners better for future study and employment. WTN uses focused feedback directing students to specific areas of improvement and is therefore effective (Hattie & Timperley, 2007). It also enables rich and motivational dialogue between faculty and learner (Elbra-Ramsay, 2022), which is especially effective in respectful classroom environments (Zhou et al., 2021). The qualitative phenomenological study proved that WTN is a useful tool; however, due to environmental demands on some learners’ time, some learners did not take up the opportunity to engage with the feedback.
Down-regulation of Toll-like Receptor 2 Via HMGB1 Blocking With Kaempferol on Kupffer Cells From Hepatocellular Carcinoma Patients
Authors: Yue Zhang , Ma Tian , Zhang Xu , Ma Tong
Published: November 2023

Background: Kaempferol is a pharmacological kaempferol that can inhibit many inflammatory factors implicated in cancer. Methods: The present study focused on kaempferol function on the immunity signaling pathway. In this study, Kupffer cells were also isolated with new methods. Results: Our results indicated that the levels of interleukin 17 (IL-17), IL-33, and IL-6 in supernatants from cultured Kupffer cells from patients were increased after stimulation with high mobility group box-1 (HMGB1), but the levels of these cytokines decreased after using kaempferol to prevent inflammation. Conclusion: The findings of this study imply that the reduction of the Toll-like receptor 2 (TLR2) pathway and T helper 17 cell polarization may be due to HMGB1 blocking with Kaempferol in hepatocellular carcinoma.
Application and Immunogenicity of Aptamers in Cancer Therapy
Authors: Ghazizadeh Arin , Amazadeh Raha , Ziyamolki Mahyar , Olfati Amirhossein , Kumar Shalen , Gholikhani Tooba
Published: November 2023

Aptamers are short single-stranded nucleic acid (DNA or RNA) or peptide sequences with a unique three-dimensional structure that bind to their targets with high specificity and affinity. Aptamers’ small size, fast and cheap production process, low immunogenicity, and high stability have made them attractive molecules in some fields of research, especially in the design of new diagnostic and therapeutic pathways. This review article discusses aptamers’ applications and immunogenic properties in the pharmaceutical sciences.
Citrullus colocynthis (L.) Schrad: A Promising Prospect Towards Pharmacology, Traditional Uses, and Potential Applications
Authors: Fallah-Huseini Hasan , Bahadori Ali , Nikkhah Elhameh , Ziaee Mojtaba
Published: November 2023

Citrullus colocynthis (L.) Schrad is an ancient plant that grows in desert areas worldwide. Its fruit is known for its medicinal uses and potential applications in the pharmaceutical and nutraceutical industries. This narrative review aims to evaluate the published information on the ethnobotanical knowledge, phytochemistry, ethnopharmacology, nutraceutical potential, and toxicological studies of C. colocynthis, highlighting gaps and potential areas for future research. The present review extensively compiles, reviews, and analyzes the best available evidence from PubMed, Scopus (Embase), Web of Science (Web of Knowledge), Cochrane Library, Google Scholar, and other sources. Scientific literature shows that C. colocynthis contains bioactive compounds such as cucurbitacin, polyphenols, flavonoids, and other potent molecules that contribute to its antidiabetic, anticancer, antioxidant, antimicrobial, and anti-inflammatory properties. However, its potential therapeutic applications for digestive and respiratory systems, and cardiovascular disorders require further exploration. The present review reveals that the plant has significant potential for pharmaceutical and nutraceutical applications, with indications of synergistic effects and combinations that neutralize side effects.
Is there correlation between flow volume and Kt/V ratio in upper arm arteriovenous fistula in patients end stage renal failure?
Authors: Turko Ensar , Gunduz Ali Mahir , Gurbuz Ali Fuat , Durmaz Fatma , Dundar Ilyas , Goya Cemil , Yokus Adem
Published: November 2023

Introduction: Chronic kidney disease is irreversible and may result in end-stage renal failure (ESRF). The kidney replacement program is determined by calculating Kt/V ratios, one of the dialysis efficiency indicators in treatment planning in routine dialysis applications in ESRF patients. We aimed to investigate whether there is a correlation between flow rate and Kt/V ratio. Methods: All patients were evaluated by B-mode ultrasonography (US) and color doppler ultrasonography (CDUS). The anastomosis line diameter was measured in the B-mode US. The fistula flow rate was calculated in a spectral examination at the anatomical location where the fistulized flow was best obtained at the anastomosis level. Patients with a fistula flow rate above 300 mL/min in CDUS examinations were considered reasonable flow rates. The fistula flow rate in these patients was compared with the Kt/V ratios. Spearman’s rank correlation coefficient was calculated since the normal distribution condition was not met to determine the relationship between variables. Results: The results of this study showed a high level (r=0.72, P=0.001) of positive and statistically significant correlation between flow rate and Kt/V ratio in upper arm arteriovenous fistula in patients with end stage renal failure. Conclusion: We found a highly positive and statistically significant correlation between fistula flow rate and Kt/V ratio. Low Kt/V ratios have different causes. Low fistula flow should be considered first in low Kt/V values.
The Effectiveness of Social Support for Patients, Who Receive Opioid Agonist Therapy
Authors: Пикиреня В.И.
Published: November 2023

В статье представлены результаты оценки эффективности социального сопровождения пациентов с опиоидной зависимостью, получающих терапию опиоидными агонистами. Дизайн исследования: открытое продольное с оценкой изменений заданных параметров группы. Инструменты диагностики: структурированное интервью, объективное состояние через заданный промежуток времени. Критерии включения: прохождение терапии опиоидными агонистами и участие в социальном сопровождении. В исследование были включены 186 пациентов. Полученные результаты: доля оставшихся в терапии опиоидными агонистами пациентов через 6 месяцев социального сопровождения составила 87,07% и в течение 12 месяцев – 77%. Качество жизни (WHOQOL-BREF) при повторной оценке повысилось на 6,17%, а у тех пациентов, кто завершил курс сопровождения и снизил риск отрыва от лечения до низкого, качество жизни повысилось на 9,7%. Таким образом, социальное сопровождение силами равных консультантов продемонстрировало высокую эффективность как в отношении а) доли пациентов, продолжающих лечение в течение длительного времени, так и в отношении б) повышения качества жизни людей с опиоидной зависимостью, получающих терапию опиоидными агонистами.

The present study elucidates the outcomes of evaluating the efficacy of social support interventions for individuals with opioid dependence who are undergoing opioid agonist therapy. The research design employed an open longitudinal approach to track the progression of predefined parameters within the participant cohort. Diagnostic tools, including structured interviews and periodic objective assessments, were employed to gather data. Inclusion criteria encompassed patients actively engaged in opioid agonist therapy and enrolled in social support programs. A total of 186 patients were enrolled in the study. The findings revealed that, after a 6-month duration of social support, the retention rate within opioid agonist therapy stood at 87.07%, and at the 12-month mark, was 77%. A subsequent evaluation of the quality of life (WHOQOL-BREF) demonstrated a notable improvement of 6.17%. Moreover, individuals who completed the social support program and reduced the risk of treatment discontinuation to a low level exhibited a significant increase of 9.7% in their quality of life. Consequently, the results substantiate the effectiveness of social support interventions, led by peer-2-peer workers, in promoting both the sustained engagement of patients in long-term treatment and the enhancement of quality of life among individuals with opioid dependence receiving opioid agonist therapy.
PELATIHAN DAN PENDAMPINGAN SKILL NASYIATUL AISYIYAH DALAM BERSTORY TELLING TEMA “ISLAMI”
Authors: Lubis Khatib , Parapat Lili Herawati , Huda Rahmat
Published: November 2023

Program pengabdian kepada masyarakat ini dengan mitra menentukan prioritas pelaksanaanpengabdian kepada masyarakat dengan fokus pada bidang skill berstory telling yanglaksanakan secara langsung dan daring. Hasil Pengabdian Kepada Masyarakat (PKM) adalahNasyiatul Aisyiyah telah memiliki skill dan dapat mempraktikkan langsung dalam berstorytelling. Telah melaksanakan Pengabdian Kepada Masyarakat mulai dari tanggal 1 Desembersampai dengan 30 Januari secara teori dan praktik. Metode pelaksanaan PKM dilaksanakansecara tatap muka langsung dan dalam jaringan.
PENEGAKAN HUKUM LALU LINTAS JALAN SECARA ELEKTRONIK SEBAGAI WUJUD PEMBANGUNAN HUKUM WILAYAH HUKUM JAKARTA SELATAN
Authors: Sekar Putri Nindyaningrum  , Gayo Sabela , Hakim Lukman
Published: November 2023

Penelitian ini akan menitikberatkan pembahasan penggunaan teknologi ETLE pada era digital dalam mengoptimalkan penegakan hukum di bidang lalu lintas demi menekan angka pelanggaran lalu lintas yang terjadi saat ini. Melalui pemanfaatan teknologi ETLE tersebut, maka pihak Satlantas akan lebih mudah melaksanakan tugasnya dalam bidang lalu lintas. Metode penelitian yang digunakan adalah penelitian hukum yuridis empiris. Penelitian bersifat deskriptif analitis. Hasil penelitian menunjukan Permasalahan dalam penelitian ini mengacu pada banyaknya pelanggaran lalu lintas yang terjadi di Indonesia pada tahun 2022 terkhusus di Wilayah Hukum Jakarta Selatan. Tercatat pada tahun 2022, penindakan terhadap pelanggaran lalu lintas sejumlah 57.756, berbanding pada tahun 2021, 29.349. Walaupun pengaturan hukum lalu lintas telah diperbaharui, akan tetapi masih banyak pelanggaran lalu lintas yang terjadi. Dalam pelaksanaan ETLE di Polres Metro Jakarta Selatan terbukti efektif dalam menangkap pelaku pelanggaran lalu lintas namun dijumpai beberapa kendala dalam pelaksanaannya. Seperti kelemahan kamera E-TLE selain itu sanksi tilang juga tidak tepat sasaran dimana mekanisme kerja ETLE ini memunculkan kemungkinan bahwa pelanggar lalu lintas bukanlah pemilik kendaraan bermotor, sedangkan Surat Tilang akan dikirimkan dengan basis data pemilik kendaraan bermotor dalam database registrasi danidentifikasi kendaraan bermotor.
Partisipasi Masyarakat dalam Proses Pembentukan KUHP Nasional untuk Mewujudkan Negara Kesejahteraan sebagai Hukum Responsif
Authors: Lawrencya Sheryn , Anisa Tasya
Published: November 2023

Pembentukan produk hukum menjadi suatu kebutuhan dalam merespon kepentingan masyarakat. Pembentukan peraturan perundang-undangan menentukan apakah mampu membagikan kenyamanan dan kesejahteraan bagi masyarakat atau menimbulkan konflik. Mendapatkan aspirasi serta kesepakatan dari masyarakat menjadi bentuk hukum yang responsif. Partisipasi seluruh elemen masyarakat menjadi hal yang penting dalam proses melahirkan produk hukum, khususnya KUHP Nasional yang telah disusun sejak tahun 1963, namun masih banyaknya pasal kontroversial dan menimbulkan perdebatan di masyarakat. Penulisan ini menggunakan metode serta teknik pengumpulan data secara yuridis normatif untuk menemukan better law dan menawarkan solusi terhadap permasalahan hukum, secara deskriptif analisis kritis dengan studi dokumen. DPR sebagai wakil rakyat menjadi peran penting dalam menampung dan menindaklanjuti aspirasi rakyat. Mampu mengenali keinginan publik demi mewujudkan konsep negara kesejahteraan dan hukum responsif. Evaluasi lebih lanjut perlu diadakan proses legislasi dengan diikutsertakannya aspirasi masyarakat.

Kata Kunci: Partisipasi Masyarakat, KUHP Nasional, Negara Kesejahteraan, Hukum Responsif.
NUEVOS MODELOS Y HORIZONTES EN LA FORMACIÓN PERMANENTE DEL PROFESORADO DE LITERATURA A PARTIR DE LA PRÁCTICA REFLEXIVA
Authors: Galarraga Arrizabalaga Haizea , Arnedo Gaztelurrutia Maialen , Alonso Amezua Idurre
Published: November 2023

Este trabajo presenta el diseño, implementación y análisis de dos procesos de formación-investigada (Lussi-Borer y Muller, 2014), llevados a cabo con el profesorado de varios cursos de dos centros de Educación Primaria, en el marco de la enseñanza de lengua y literatura. El eje vertebrador de dichas formaciones ha sido la educación literaria y sus actuales retos educativos. Partimos de una visión socio-constructivista de la educación, en la que la formación permanente del docente parte de su propia actividad y posterior reflexión. Los procesos de formación necesitan aproximarse a la práctica y conocer el trabajo docente, para así posibilitar procesos de mejora; y, a su vez, el docente necesita tomar conciencia de su propia actividad de enseñanza, mediante procesos de práctica reflexiva, como el método de la autoconfrontación, que permitan cambios en las maneras de actuar y mediar. La presente investigación sobre los procesos formativos ha tenido como objetivo conocer las trazas de actividad o características de la práctica de los docentes y ahondar en los aspectos trabajados en las sesiones de formación. De esa manera, se ha podido tomar conciencia de los efectos que puedantener dichos aspectos en el desarrollo de la competencia literaria en el aula. Los resultados obtenidos muestran que una formación diseñada en base a la práctica reflexiva tiene gran potencial a la hora de fomentar cambios sustanciales en los procesos de enseñanza-aprendizaje del aula.
THE IMPLEMENTATION OF MARRIAGES ON SONGO RAMADHAN NIGHT IS A LOCAL WISDOM OF THE PARENGAN PEOPLE TUBAN DISTRICT
Authors: Novitasari Nurul
Published: November 2023

This study is about wedding culture on Songo Ramadlan night in Parengan Tuban, East Java. In this research location, there is a wedding tradition called malem songo that has been passed down from generation to generation and it is not known for certain when this tradition was first implemented.. Seeing this, the researcher carried out research with the aim of (1) knowing the factors that cause marriages to occur on the night of the 29th of the month of Ramadan in the community of Parengan District, Tuban Regency (2) to find out the perspective of customary law and Islamic law on the occurrence of marriages on the night of the 29th of Ramadhan in the people of Parengan District, Tuban Regency. This research uses a type of empirical legal research where all information is obtained from documentation and interviews, using a qualitative approach. Meanwhile, the data collected is primary data, namely interviews with Parengan District KUA officials, figures and several community members who held weddings at Night Songo and secondary data from books that have relevance in research, which is then edited, checked and compiled carefully and arranged in such a way analyzed. The results of this research show that getting married at night songo has become a tradition and is deeply rooted in the people of Parengan District, which is considered to bring blessings in Javanese culture and is seen as a form of local wisdom. Therefore, the implementation of this marriage is to avoid complications, because the Songo Ramadhan night is not regulated by religious principles or Javanese law.
DISEÑO DE UNA HERRAMIENTA PEDAGÓGICA PARA MEJORAR LA TÉCNICA DE LANZAMIENTO DE GIRO EN EL DEPORTE DE GOALBALL
Authors: Fernando-Kerguelen Jesús , Martínez Keyla , Padilla Yamir
Published: November 2023

El presente articulo tiene como objetivo presentar el diseño de un material didáctico para favorecer el dominio y la enseñanza de una técnica de lanzamiento en deportista de goalball la metodología es inicialmente estableciendo el perfil del deportista en el cual se analiza la necesidad de aprender y mejora en su técnica deportiva, se hace un abordaje de conceptos de discapacidad y del deporte ,así mismo de la literatura relacionada con la temática, se realiza una propuesta del diseño conceptual. Luego se establece el diseño, se detallan los materiales y el cálculo de las fuerzas a las que estará sometido dicho material, se selecciona el material idóneo, se procede al diseño final y por ultimo las pruebas y la evaluación del mismo, frente a los resultados se encontró que el material elaborado le brinda más soporte emocional se fortalece la confianza sobre todo al momento de dar un giro en el aprendizaje de  la técnica, a través de este material se facilitó más el aprendizaje dentro de la conclusiones encontramos que las personas con discapacidad visual congénita es más complejo al enseñanza de la técnica en este deporte , que cuando hay confianza en sí mismo y la que le pueda ofrecer el entrenador  se facilita más el aprendizaje y eso fue lo que básicamente le genero este material a los deportista sentirse cómodo seguro de realizar el giro , el material proporciona más eficiencia al momento de aprender la técnica y por lo tanto se gasta menos tiempo y finalmente es importante el desarrollo de una buena motricidad desde actividades de independencia y autonomía antes de someterse al aprendizaje de la técnica con el material.
Recebido em: 20/08/2023
Reformulado em: 23/11/2023
Aceito em: 24/11/2023
Reconversão cultural nas narrativas dos egressos do Programa de Ações Afirmativas:
Authors: Panerai Araujo Margarete , Antunes dos Santos Rosemeri
Published: November 2023

Esta pesquisa tem como tema central as narrativas dos egressos do Programa de Ações Afirmativas da Universidade Federal do Rio Grande do Sul - UFRGS, suas trajetórias sociais, e a possibilidade de construção do conhecimento, e reconversão do capital cultural e habitus. A pesquisa abrangeu o período de ingresso dos cotistas entre 2008 e 2012. O percurso teórico teve como foco as categorias de habitus, classe e capital cultural de Pierre Bourdieu. O percurso metodológico utilizado foi de uma pesquisa quantitativa e qualitativa, do tipo bibliográfica, documental e exploratória, a partir da história oral. Foram enviados questionários on line para todo universo de diplomados, contudo a amostra dessa pesquisa se concentrou em 155 diplomados e foram realizadas ainda entrevistas temáticas com 10 egressos do Programa. Os dados obtidos revelam que a experiência vivida pelos alunos cotistas nessa amostra proporcionou uma ressignificação no seu capital cultural e habitus.
BIOCHEMICAL CHARACTERIZATION AND ANTIMICROBIAL PROPERTIES OF ICE CREAM ENRICHED WITH ANTIOXIDANT ENCAPSULATED PROPOLIS
Authors: Gunes M.E. , Keskin S , Alkan P.E. , Keskin M , Kolayli S
Published: November 2023

Microorganism food poisoning is one of the foodborne illnesses in the world. The interest in natural preservatives has increased since the lack of acceptability in using synthetic preservatives. Propolis, a resinous mixture, is a natural product produced by honey bees to protect their hives against microorganisms. It is considered a natural food supplement and preservative owing to its high antimicrobial and antioxidant activities. However, its resinous nature (not readily soluble in water), ethanol solubility, specific strong smell and taste limits its usage as a natural preservative. Encapsulation of propolis ethanol extract with natural polymers like alginate and pectin may overcome these limitations. Main aim of this study was to test powdered form of propolis as a natural preservative in ice cream as model food. For this purpose propolis, after extraction and characterization, was encapsulated by using pectin and converted into powdered form. Antimicrobial activity of prepared ice cream itself against S. aureus (ATCC 25923), E. coli (ATCC 28712), E. faecalis (ATCC 51299), K. pneumoniae (ATCC 700603) and B. cereus (patient isolate) was tested. Total phenolic content and ferric reducing antioxidant power of propolis were noted as 46.26 ±1.18 mg GAE/mL and as 0.27 ±0.07 µmol FeSO4.7H2O/mL, respectively. The encapsulation efficiency was found 95%. Encapsulation of propolis ethanol extract improved the homogenization of propolis active compounds in ice cream. This resulted in obtaining an ice cream with high antimicrobial and antioxidant activities. In conclusion, the use of encapsulated active compounds of propolis ethanol extract improved the both antimicrobial and antioxidant activity of the ice cream produced in a natural way.
Keywords: antioxidant activity, antimicrobial activity, ionic gelation, ice cream, propolis
La difusión de las ideas de John Dewey en el Paraguay por Ramón Indalecio Cardozo
Authors: García José E.
Published: November 2023

The American John Dewey and the Paraguayan Ramón Indalecio Cardozo are two outstanding representatives in the field of education in the first half of the 20th century, in their respective countries. Likewise, both devoted their attention to psychology, due to the interest that it arouses in itself, or as an instrument to strengthen their approaches to the field of pedagogy. Dewey produced one of the first Psychology texts published in his country and theorized about the nature of the reflex arc, establishing the conceptual foundations of functionalism. Cardozo fostered the applications of psychology in the field of school education, introduced the ideas of some of the most influential authors of his time to Paraguay, and promoted the use of the first psychometric tests. The work lines of both authors met in 1923, with the presentation of Dewey’s ideas by Cardozo, in an article published in 1923, now a century ago. The purpose of this paper is to review the reception of Dewey’s ideas in Paraguay by Cardozo, to analyze the discusión that the Paraguayan author made about his American counterpart, and to evaluate the impact of Dewey’s ideas on the work of Cardozo and the diffusion of the active School in Paraguay. The article is of a historical and argumentative nature and is supported by a review of the primary and secondary sources that are relevant to the understanding and study of the subject matter. At the same time, it seeks to be a contribution to psychological literature on the first century of the first diffusion of John Dewey’s pedagogical and psychological ideas in Paraguay.
Efficacy of pemafibrate in patients with dyslipidemia: A systematic review and meta-analysis of randomized controlled trials
Authors: Almeida Balieiro Caroline Cristine , Barbalho Maria Esther , Fonseca Luiza Mendes , Nakajima Noah Romero , Gobbo Marcela Mizuhira , Assunes Gonçalves Beatriz Polachini , Teixeira Sirena Eduardo Cesar , Marinho Alice D. , Moreira Matheus J. B. , de Lima Natália Nóbrega
Published: November 2023

This study aimed to evaluate the efficacy of pemafibrate in patients with hypertriglyceridemia compared to a placebo or fenofibrate through a rigorous systematic review process. To achieve this, we conducted comprehensive searches in the PubMed, Cochrane Library, and Embase databases. The data extraction process was based on published reports, and the assessment of study quality adhered to the PRISMA guidelines. A random-effects model was employed to calculate mean differences (MD) and 95% confidence intervals (CI). Statistical significance was established at P < 0.05, with I² values exceeding 25%, denoting a significant degree of heterogeneity. The primary outcomes of interest were MDs in triglycerides (TG) and non-high-density lipoprotein (HDL) cholesterol. The review protocol was registered with PROSPERO under the identifier CRD42022374852. Nine studies involving 12,644 patients were included, with 6699 (53%) patients receiving pemafibrate. The meta-analysis revealed a significant reduction in serum TG levels in the intervention group (0.4 mg/day) compared to the placebo group (MD: −48.29; 95% CI: −61.45 – −35.13; P < 0.0001; I² = 93%). Pemafibrate (0.4 mg/day) also led to significantly lower non-HDL cholesterol levels compared to control (MD: −6.35; 95% CI: −10.62 – −2.08; P < 0.0001; I² = 82%). There were no significant differences in TG reduction between pemafibrate (0.2 mg/day) and fenofibrate (200 mg/day) (MD: −2.90; 95% CI: −12.90 – 7.11; P = 0.003; I2 = 83%), or between pemafibrate (0.1 mg/day and 0.2 mg/day) and placebo (TG and non-HDL cholesterol levels). In conclusion, pemafibrate demonstrated efficacy in decreasing TG and non-HDL cholesterol levels for dyslipidemia patients, especially at a dosage of 0.4 mg/day compared to a placebo.
Perancangan Sistem Informasi Rekam Medis Terpadu Dalam Upaya Meningkatkan Pelayanan Rumah Sakit Jiwa Tampan Prov. Riau
Authors: Darmanta Sukrianto Irwandi Tanjung,
Published: November 2023

The purpose of processing medical records at the Mental Hospital Handsome is to support the achievement of orderly administration in an effort to achieve the goal of the hospital is improving the quality of health services in hospitals. Delays in medical records impact is not good for the health service to the patient, because the time for the registration process to do medical action becomes long. Besides losing the status of the patient's history to make trouble and impede medical records medical action in treating patients. The purpose of this study to realize rapid and information systems to facilitate the agency in carrying out its duties. Researchers began designing of the Flow of Information Systems (ASI), Context Diagram (CD), Data Flow Digram (DFD), Entity Relationship Diagram (ERD), as well as print reports generated. With a system of medical record information, it can improve the service to the patient medical record. However, the need for the development of the system that has been made so that it can function properly.
Kontroler Alarm Rumah VIA SMS Menggunakan Microcontroller AT89S51 dan Handphone Nokia 6210 didukung Oleh Basic Compiler
Authors: Ayu Fitri
Published: November 2023

A house security system is one of the applications of  microcontroller chip benefit. This system can reduce the usage of human power to control a house security eventhough the owner is not in the house.  This research was done  by designing, creating and implementing all system components. The components are microcontroller as a process controller, basic compiler as programming language, limit switch as input device to system, barlet and buzzer whitch are used as SMS sending process activation, and the last is Nokia 6210 used for sending SMS to the house owner’s phone. This research showed that the tools function properly and can be developed in larger scale. This research is aimed  to develop Microcontroller AT89S51 application as a house security controller.