bluuebunny/crossref_metadata_2025 huggingface dataset:
Empirical Testing of Business Process on Implementation of Accounting Information System
Authors: Rapina Rapina , Kuang Tan Ming , Rahmatika Dien Noviany , Suhenda Fahmi Dwi
Published: May 2023

Accounting is currently used in a variety of commercial processes. The commercial process relates to the information system used by the organization, where the implementation of the accounting information system when preparing the organization's financial reports is still experiencing some problems. The purpose of this study is to conduct empirical testing that business processes can have a significant effect on the use of accounting information systems for competitive advantage. The context of this study is that the implementation of accounting information systems in Indonesia based on the accounting data they produce is not satisfactory. The results of the research show that the accounting information system used is influenced by business processes. Implementation of accounting information systems has not been qualified in accordance with the expectations of the banking world. This is because the dimensions of business processes namely time, quality of internal processes, and process flexibility have not been fully considered in accounting information system implementation.
La incidencia del fenómeno de la externalización en la Administración General del Estado. ¿Existe algún límite?
Authors: Cantero Martínez Josefa
Published: May 2023

Este trabajo analiza la incidencia que está teniendo en la Administración general del Estado la denominada externalización de funciones públicas. Este fenómeno responde a un intento de trasladar al ámbito administrativo una técnica muy utilizada en las empresas privadas. Con ella se traslada a un tercero el ejercicio de determinadas funciones propias de esa empresa. Se recurre a los principios de eficiencia y eficacia para justificar el empleo de esta técnica. Sin embargo, su aplicación a la Administración plantea numerosos interrogantes. En este trabajo se pretende, no sólo reconducir esta técnica a las clásicas categorías administrativas, sino también fijar sus límites. En este sentido, el ejercicio de potestades públicas, de funciones que implican el ejercicio de autoridad o la salvaguardia de intereses generales del Estado deben ser límites ineludibles. Además, existen determinados preceptos de nuestro ordenamiento jurídico que nos permiten concretar todavía más los difusos contornos de esta figura.
Transformation of Higher Learning in South Africa: Perceptions and Understanding of Speech-Language Therapy and Audiology Undergraduate Students
Authors: Abrahams Farieda , Moroe Nomfundo Floweret , Khoza-Shangase Katijah
Published: May 2023

The professions of speech-language therapy and audiology in South Africa developed under apartheid and historically consisted of and catered to a predominantly white English- or Afrikaans-speaking minority population. Over 25 years into democracy, there continues to be a stark incongruence between the demographic profile of the South African population and the speech-language and hearing (SLH) professions in terms of “race”, linguistic, and cultural diversity, and this has implications for training as well as clinical service provision within the South African context. This article explores undergraduate students’ perceptions and experiences of transformation within South African SLH university training programmes through a cross-sectional descriptive survey research design. A self-developed questionnaire was used to collect data from students enrolled in SLH programmes at South African universities. Thematic analysis identified two themes: 1) progress towards attainment of transformation and, 2) visibility of transformation. These findings highlight the need for diversity through inclusivity, redressing past injustices and incorporating local knowledge into current training and practice. These findings have global relevance for transformation in higher education, not just in the field of SLH. Implications for translation of theory and/or knowledge into practice, with more visible and deliberate application of policy in curriculum reform and institutional culture, are raised.
Challenges of Enforcing Anti-cyber Bullying Laws on Teen Sexting in South Africa
Authors: Mthembu Mpakwana
Published: May 2023

The protection of children from harmful online content is upheld in international and domestic legal instruments. In South Africa, children enjoy the right to privacy, freedom of expression and protection from exposure to abusive and exploitative materials when they go online. However, in recent years, many South African children have been involved in creating and distributing harmful and illegal messages through the Internet. This prompts the question of whether the South African legal framework is adequate to protect children and shield them from cyberbullying or sexting. This study re-examines the ability of South African anti-cyberbullying laws to protect children online. Cyberbullying takes many forms, and therefore, this study is confined to sexting—the participation in communicating nude pictures through mobile phones. This study is based on the purposive sampling of several well-known cases of sexting that occurred within the South African schooling environment. The findings of the study confirm the view that South African anti-cyberbullying laws are less effective in curbing children’s participation in sexting. In addition, children’s creativity with new age-technologies has tended to complicate and undermine efforts to protect the same children from the harms of sexting. The study concludes that many South African parents appear ill-equipped to teach their children to handle safe sexting and to protect these children from becoming victims of the frequently disastrous consequences of sexting, which may even include suicide.
Analyzing of Using Educational Technology to Improve the Quality and Equity of Learning Outcomes at Politeknik Maritim Negeri
Authors: Sri Tutie Rahayu
Published: May 2023

This study aimed to identify the use of educational technology in supporting the education of the next generation who want to improve the quality and equity of learning outcomes. The researcher carried out a series of data collection at one of the tertiary institutions, namely the Indonesian state maritime polytechnic. The researcher obtained the needed data through the location observation interview approach and documentation. Next, it analyze uding a phenomenological approach. The secondary and primary data coding was checked, organized, organized, and finally interpreted to get relevant and valid conclusions to answer this study's problems. After a series of analyses and discussion of data, this study concludes that there were several use for technology to support activities and accelerate learning at the Indonesian State Maritime Polytechnic, including that technology has become a core in learning because the power of innovation and revolution provides equity learning result in student learning. These various features and technology platforms enabled very effective and innovative learning, such as in efforts to develop the quality of lecturers with a variety of choices for learning or artificial intelligence to enable learning to occur more autonomously and accelerate training models and other classroom exercises. The study's results provide additional information for similar studies in the future. Keywords: Equity Learning Outcome, Quality Learning Outcome, Educational Technology
Pyoderma Gangrenosum in a Patient With Dubowitz Syndrome: a New Comorbidity?
Authors: Bevilacqua Matteo , Granieri Giammarco , Fidanzi Cristian , Salvia Giorgia , Margiotta Flavia , Michelucci Alessandra , Romanelli Marco , Dini Valentina
Published: May 2023

Introduction. Dubowitz syndrome is a rare genetic disease with only a few cases reported in the literature. It is characterized by growth retardation, microcephaly, facial dysmorphism and higher risk of developing cancer and cardiomyopathies. PG is an autoinflammatory disorder that causes painful ulcers to develop on the skin and has not been previously associated with Dubowitz syndrome. Case Presentation. The authors report the case of a 50-year-old female with Dubowitz syndrome who developed painful ulcerative lesions. An incisional biopsy was performed to rule out other diagnoses, and a subsequent clinical diagnosis of PG was made. The patient was treated with specialized wound dressings and oral glucocorticoids. The clinical picture improved consistently after 7 weeks of therapy. Conclusions. This case report, to the authors’ knowledge, is the first to suggest a possible association between Dubowitz syndrome and PG and also to indicate an effective treatment.
Prediction-inspired intelligent training for the development of c-RASAR models for organic skin sensitizers: Assessment of classification error rate from novel similarity coefficients
Authors: Banerjee Arkaprava , Roy Kunal
Published: May 2023

The advancements in the field of cheminformatics have led to a reduction in animal testing to estimate the activity/property/toxicity of query chemicals. Read-Across Structure-Activity Relationship (RASAR) is an emerging concept that utilizes various similarity functions derived from chemical information to develop highly predictive models. Unlike quantitative structure-activity relationship (QSAR) models, RASAR descriptors of a query compound are computed from its close congeners instead of the compound itself, thus targeting predictions in the model training phase. The objective of the present study is not to propose new QSAR models for skin sensitization, but to demonstrate the enhancement in the quality of predictions of the skin-sensitizing potential of organic compounds by developing classification-based RASAR (c-RASAR) models. A diverse, previously curated, dataset was collected from the literature, for which 2D descriptors were computed. The extracted essential features were then used to develop a classification-based linear discriminant analysis (LDA) QSAR model. Furthermore, from the Read-Across-based predictions, RASAR descriptors were calculated using the basic settings of the hyperparameters for the Laplacian kernel-based optimum similarity measure. After feature selection, an LDA c-RASAR model was developed which superseded the prediction quality of the LDA-QSAR model. Various other combinations of RASAR descriptors were also taken to develop additional c-RASAR models all showing better prediction quality than the LDA QSAR model while using a lower number of descriptors. Various other machine learning c-RASAR models were also developed for comparison purposes. In this work, we have proposed and analyzed three new similarity metrics: gm_class, sm1, and sm2. The first one is an indicator variable used to generate a simple univariate c-RASAR model with good prediction ability, while the rest two are similarity indices used to analyze possible activity cliffs in the training and test sets and are believed to play an important role in the modelability analysis of datasets.
CO2-to-methanol electroconversion on a molecular cobalt catalyst facilitated by acidic cations
Authors: Yu Sunmoon , Yamauchi Hiroki , Kim Junghwa , Huang Botao , Xu Hongbin , Zheng Daniel , Wang Xiao , Iriawan Haldrian , Menga Davide , Shao-Horn Yang
Published: May 2023

The crucial role of electrolyte cations in CO2 electroreduction has received intensive attention. One prevailing theory is that through electrostatic interactions or direct coordination, larger cations such as Cs+ can better stabilize the key intermediate species for CO and multicarbon (C2+) product generation, for example, on silver and copper. Herein, we show that smaller, acidic alkali metal cations greatly enhance CO2-to-methanol conversion kinetics (Li+ > Na+ > K+ > Cs+) on an immobilized molecular cobalt catalyst unlike the trend for CO and C2+. Through kinetic isotope effect studies and electrokinetic analyses, we found that hydration shell of a cation serves as a proton donor in the rate-determining protonation step of adsorbed CHO where acidic cations promote the proton-coupled electron transfer. This study reveals the promotional effect of cation solvation environment on CO2 electroreduction beyond the widely acknowledged stabilizing effect of cations.
Computational Investigations Complement Experiment for a System of Non-Covalently Bound Asphaltene Model Compounds
Authors: King Nathanael J. , Brown Alex
Published: May 2023

The nanoaggregation of asphaltenes is an important and poorly-understood field at the juncture of petrochemistry, analytical chemistry, and computational chemistry. As- phaltene precipitation from crude oils and bitumens, and subsequent deposition in and on equipment causes plugged or constricted pipelines, coking and fouling on heaters and heat exchangers, and inactivation of catalysts, to enormous economic and environ- mental expense. However, the mechanisms behind the aggregation and precipitation of asphaltenes are still poorly understood. In this paper, the aggregation of asphal- tene model compounds has been explored using a combination of density functional tight-binding (DFTB) and density functional theory (DFT), in a manner that revisits a prior experimental study. The model compounds investigated include a porphyrin with an acidic side chain, and a three-island archipelago compound with pyridine as the central island, and pyrene for the outer islands. The possible stoichiometries and conformations for complexes were explored and compared to the experimental results. Our results show that there are four possible complexes involving these two model compounds with large (K>1000) equilibrium constants of formation, which will exist in competition with each other. We find that both hydrogen bonding and π−π stacking are important to this aggregation. On the other hand, neither water-mediated aggrega- tion nor coordination to open porphyrin sites was found to be significant, despite some suggestions in the literature that these might be important. The multiple possible stoichiometries of complexes confound some of the analysis done in the experimental paper, as Job plots assume that only one complex is present. Gibbs free energies of association were determined for various complexes, with and without microhydration, at the ωB97X-V/def2-QZVPP//ωB97X-D4/def2-SVP level of theory. We also briefly explore some of the factors influencing the change in NMR chemical shift for select nuclei measured in the experimental paper.
Combining Surface-Induced Dissociation and Charge Detection Mass Spectrometry to Reveal the Native Topology of Heterogeneous Protein Complexes
Authors: Du Chen , Cleary Sean , Kostelic Marius , Jones Benjamin , Kafader Jared , Wysocki Vicki
Published: May 2023

Charge detection mass spectrometry (CDMS) enables the direct mass measurement of heterogenous samples on the megadalton scale, as the charge state for a single ion is determined simultaneously with mass to charge ratio (m/z). Surface-induced dissociation (SID) is an effective activation method to dissociate the noncovalent protein complexes without extensive gas-phase restructuring, producing various subcomplexes reflective of the native protein topology. Here, we demonstrate that using CDMS after SID on the Orbitrap platform offers subunit connectivity, topology, proteoform information, and relative interfacial strengths of the intact macromolecular assemblies. SID dissects the capsids (~3.7 MDa) of adeno-associated viruses (AAVs) into trimer-containing fragments (3mer, 6mer, 9mer, 15mer, etc) that can be detected by the individual ion mass spectrometry (I2MS) approach on Orbitrap instruments. SID coupled to CDMS provides unique structural insights into heterogenous assembles that are not obtained by traditional MS measurements.
Deep generative model of constructing chemical latent space for small to large molecular structures with 3D complexity
Authors: Ochiai Toshiki , Inukai Tensei , Akiyama Manato , Furui Kairi , Ohue Masahito , Matsumori Nobuaki , Inuki Shinsuke , Uesugi Motonari , Sunazuka Toshiaki , Kikuchi Kazuya , Kakeya Hideaki , Sakakibara Yasubumi
Published: May 2023

The structural diversity of chemical libraries, which are systematic collections of compounds that have potential to bind to biomolecules, can be represented by chemical latent space. A chemical latent space is a projection of a compound structure into a mathematical space based on several molecular features, and it can express structural diversity within a compound library in order to explore a broader chemical space and generate novel compound structures for drug candidates. Many of the natural compounds produced by living organisms have complicated structures and are highly biologically active. However, no deep learning models exist that can effectively construct chemical latent spaces to handle large and complex compound structures, such as those found in natural compounds, and furthermore manage chirality, which is an essential factor in the 3D complexity of compounds. In this study, we developed a new deep-learning method, called NP-VAE, based on variational autoencoder for handling natural compounds, and constructed a chemical latent space that projected large and complex compound structures including chirality. NP-VAE was successful in construction of the chemical latent space that showed higher accuracy with respect to reconstruction and generalization than the state-of-the-art deep learning methods. Furthermore, by exploring the acquired latent space, we succeeded in comprehensively analyzing a compound library containing natural compounds and generating novel compound structures with optimized functions.
Defect Control Strategies for Al(1-x)Gd(x)N Alloys
Authors: Ud Din Naseem , Lee Cheng-Wei , Yazawa Keisuke , Nemeth William , Smaha Rebecca W. , Haegel Nancy M. , Gorai Prashun
Published: May 2023

Tetrahedrally-bonded III-N and related alloys are useful for a wide range of applications, from optoelectronics to dielectric electromechanics. Heterostructural AlN-based alloys offer unique properties for piezoelectrics, ferroelectrics, and other emerging applications. Atomic-scale point defects and impurities can strongly affect the functional properties of materials, and therefore, it is crucial to understand the nature of these defects and mechanisms through which their concentrations may be controlled in AlN-based alloys. In this study, we employ density functional theory with alloy modeling and point defect calculations to investigate native point defects and unintentional impurities in Al(1-x)Gd(x)N alloys. Among the native defects that introduce deep mid-gap states, nitrogen vacancies (V_N) are predicted to be in the highest concentration, especially under N-poor growth conditions. We predict and experimentally demonstrate that V_N formation can be suppressed in thin films through growth in N-rich environments. We also find that Al(1-x)Gd(x)N alloys are prone to high levels of unintentional O incorporation, which indirectly leads to even higher concentrations of deep defects. Growth under N-rich/reducing conditions is predicted to minimize and partially alleviate the effects of O incorporation. The results of this study provide valuable insights into the defect behavior in wurtzite nitride-based alloys, which can guide their design and optimization for various applications.
Regioselective Direct C−H Bond (Hetero)arylation of Thiazoles Enabled by a Novel Iminopyridine-Based α‐Diimine Nickel(II) Complex Evaluated by DFT Studies.
Authors: Damien E. Arche Phillip , Chatterjee Shubham , Talukder Md Muktadir , T. Miller Justin , Michael O. Cue John , M. Udamulle Gedara Chinthaka , Lord Richard , C. Biewer Michael , Cisneros G. Andrés , C. Stefan Mihaela
Published: May 2023

Direct C−H bond arylation is a highly effective method for synthesizing arylated heteroaromatics. This method reduces synthetic steps and minimizes the formation of impurities. We report an air and moisture-stable iminopyridine-based α-diimine nickel (II) complex for direct C5-H bond arylation of thiazole derivatives. Under low catalyst loading and performing the reactions at lower temperatures (80 °C) under aerobic conditions, we produced mono- and diarylated thiazole units. Competition experiments and density functional theory calculations (DFT) revealed that the mechanism of C−H activation in 4-methylthiazole involves electrophilic aromatic substitution.
Replacement of core team members on embedded implementation research teams: experiences from Latin America and the Caribbean
Authors: Becerril-Montekio Victor , Torres-Pereda Pilar , García-Bello Luis Alberto , Alcalde-Rabanal Jacqueline
Published: May 2023

Objective.

To understand how replacement of decision-makers (DMs) serving as principal investigators (PI) or co-PIs on research teams may affect the feasibility and value of embedded implementation research (EIR) used to improve health policies, programs, and services in Latin America and the Caribbean.

Methods.

This was a descriptive qualitative study based on 39 semistructured interviews with 13 embedded research teams selected by financing agencies to explore team composition, interaction among members, and research results. Interviews were conducted at three points during the study period from September 2018 to November 2019; data were analyzed from 2020 to 2021.

Results.

Research teams were found to be operating in one of three situations: (i) permanent core team (no change) with either active DM or inactive DM participation; (ii) replacement of DM–PI or co-PI that did not affect EIR research; and (iii) replacement of DM–PI that affected EIR.

Conclusions.

To ensure EIR continuity and stability, research teams should include high-level DMs together with more technical staff performing essential implementation activities. This structure could improve collaboration among professional researchers and ensure greater embeddedness of EIR to strengthen the health system.
Second kind shifted Chebyshev polynomials and power series method for solving multi-order non-linear fractional differential equations
Authors: Amr M. S. Mahdy  , Ali A. A. El-dahdouh
Published: May 2023

In this paper, we use shifted Chebyshev approximations with the second kind [25] and fractional power series method (FPSM) ([3], [8]) to solve the multi-order non-linear fractional differential equations. The fractional derivative is described in the Caputo sense. The properties of shifted Chebyshev polynomials with the second kind are utilized to reduce multi-order NFDEs. The system of non-linear of algebraic equations which solved by using Newton iteration method. We compared with FPSM. The results are compared withthe traditional methods [23].
Generalized Ulam - Hyers stability of on (AQQ): Additive-quadratic-Quartic functional equation
Authors: John M. Rassias  , M. Arunkumar  , E. Sathya  , N. Mahesh Kumar
Published: May 2023

In this paper, the authors obtain the general solution and generalized Ulam - Hyers stability of an (AQQ): additive - quadratic - quartic functional equation of the form$$\begin{aligned}f(x+y+z) & +f(x+y-z)+f(x-y+z)+f(x-y-z) \\=2[f(x+y) & +f(x-y)+f(y+z)+f(y-z)+f(x+z)+f(x-z)] \\& -4 f(x)-4 f(y)-2[f(z)+f(-z)]\end{aligned}$$by using the classical Hyers' direct method. Counter examples for non stability are discussed also.
Chinese Civilization in Malaysia: History and Contribution
Authors:   Akademi Pengajian Bahasa, Universiti Teknologi MARA, 40450 Shah Alam, Malaysia, Zakaria Mohd Fahimi , Ibrahim Ashlah ,   Centre for Fundamental Studies, Management and Science University, 40100 Shah Alam, Malaysia
Published: May 2023

Malaysia is a multicultural country with diversity. Among the cultures here are the Chinese inclusive of all their subcultures. This paper discusses the contribution of the Chinese civilization to Malaysia. Malaysian Chinese has contributed a lot to the building of Malaysia both culturally and economically. They arrived in Malaya in the year of 1500 and have embedded themselves by bringing their economical capabilities as well as religious and linguistic values. Chinese Malaysian have layered identities based on ancestry. Upon arrival in Malaya many years ago, they were here as traders who eventually married locals and begun the early assimilation of Malayan Chinese. However, in the early of 1900 they were brought into Malaya under the British rule to mine the tin mines in land rich in natural resources. The final wave is recent and include Malaysia’s My Second Home program. Among the contributions of Malaysian Chinese is wealth. Some of the richest Malaysians and successful businesses are Chinese-owned. There is also no shortage of Chinese architecture in Malaysia and that has also influenced the art industry. Mandarin is the main language spoken by Malaysian Chinese and is used in all vernacular schools and businesses as the official method of communication. However, there are many sub-cultural languages among the Chinese community as well. The Chinese have also brought their religion which is mainly Buddhism, Taoism, or Confucianism. Chinese religions are more of a way of life rather than a worship of a supreme being.
E-learning Technologies Opportunities on Students’ Learning Motivation and Performance: A Descriptive Study
Authors:   Department of Information Systems, International Islamic University Malaysia, 53100 Kuala Lumpur, Malaysia, Sofiadin Aidrina
Published: May 2023

The effectiveness of e-learning significantly impacts the student learning process and the quality of the e-learning system. Literature highlights numerous technologies in e-learning that enhance online education quality. Students learning experience through the face-to-face approach may not be the same as e-learning with the emerging technology trends such as Artificial Intelligence (AI), Virtual Reality (VR), Augmented Reality (AR), Mixed Reality (MR) and Extended Reality (XR). Thus, there is a need to understand how e-learning technologies such as AI, VR, AR, MR and XR will impact the student's learning motivation and performance. This study focuses on students’ learning motivation and performance at one of the top ten universities in Malaysia. A descriptive study was applied, and the data from questionnaires were analysed using descriptive statistics. The results enlightened some opportunities for AI, VR, AR, MR, and XR that may enhance students’ learning motivation and performance while promoting a humanising education.
Hybrid Management for Traumatic Iliac Arteriovenous Fistula
Authors: Marinho de Oliveira Góes Junior Adenauer , Oliveira Feijó Matheus , Beatriz Araújo de Albuquerque Fernanda
Published: May 2023

Traumatic arteriovenous fistulas are usually the evolution of non-treated contiguous arterial and venous injuries inflicted by firearm projectiles. As time passes, these fistulas can lead to systemic and local repercussions. Endovas-cular management offers great benefit in reducing the risks of open surgery for correcting these fistulas, but unfor-tunately some endovascular resources are not always available.In this situation, a hybrid management offering an endovascular strategy to control bleeding, while allowing an open disconnection of the affected artery and vein, may be useful in dealing with these complex injuries. In this article, the authors report a case of traumatic arteriovenous fistula between the common iliac vessels, managed with a hybrid strategy and make comments about practical issues regarding planning the open part of the procedure and anticipating possible complications when treating such injuries.
What business model factors make SMEs more profitable?
Authors: Ortiz García de las Bayonas José Miguel , Parra Meroño María Concepción , Wandosell Fernández de Bobadilla Gonzalo
Published: May 2023

The aim of this article is to detect the business model factors that increase firm performance. To carry out this research, a survey was conducted among the CEOs of seventy companies in the Region of Murcia, Spain, belonging to different sectors of economic activity. The empirical evidence obtained indicates that the characteristics of a company's business model affect its performance and future viability. In this sense, the article confirms that the business model factors that contribute to improving the future viability of a firm are mainly innovation, professionalization of the economic-financial area, investment in employees, and strengthening of the commercial area. Therefore, firms that wish to improve their long-term performance should especially strengthen these characteristics of the business model.
AGE DYNAMICS OF THE LIVE WEIGHT OF THE KAZAKH WHITE-HEADED BREED OF BEEF CATTLE
Authors:   Timirâzevskaâ selʹskohozâjstvennaâ akademiâ, BISSEMBAEV A.T.
Published: May 2023

The aim of the study is to establish the age dynamics of the variability of live weight with the average daily liveweight gain of the Kazakh whiteheaded breed of beef cattle. In all analyzed agricultural enterprises at the age of six months, the live weight of bulls varied from 172.4 kg to 196.5 kg, and in heifers – from 160.1 kg to 180.7 kg, respectively. According to the indicators of the average daily liveweight gain, there are some differences between bulls and heifers. From birth to 210 days of age, the average daily liveweight gain was 846.03 g in bulls, 784.4 g in heifers; from 210 days of age to one year of age it was 732 g in bulls and 599 g in heifers; from birth to one year of age, the average daily liveweight gain was 793.6 g in bulls and 707.5 g in heifers. Bulls at the age of six months generally meet the requirements of the breed standard, characterized by high coefficients of variability. The live weight of bulls in the farms “Zhannat”, “Tolegen” and “Alem” at the age of six months meets and slightly exceeds the requirements of the breed standard by 15.2 kg (8.2%), 13.0 kg (7.1%), 13.6 kg (7.4%), and in heifers by 15.7 kg (8.9%), 8.1 kg (4.8), 13.2 kg (7.6%), respectively. The value of the coefficient of variability of live weight has average values with a slight excess in heifers. It was found that the live weight of bulls in the farm “Kairat” and the farm “Naryn” exceeded the breed standard by 26.5 kg (13.5%) and 21.1 kg (11%), heifers by 20.7 kg (11.5) and 7.8 kg (4.6%), respectively, and belongs to the elite classes. The average daily liveweight gain of young Kazakh white-headed breed in the studied farms varied from 826.7 to 944.2 g in bulls, and in heifers from 711.1 to 887.2 g, respectively that indicates a relatively high liveweight gain obtained in farm conditions.
Quantitative Determination of Surface Morphology of Red Blood Cell
Authors: Kocahan Yılmaz Özlem
Published: May 2023

In this study, the determination of the surface morphology of red blood cell (RBC) from interferogram image obtained by quantitative phase imaging (QPI) method is presented. QPI, is an optical measurement method frequently used in recent years, allows to obtain quantitative data for different samples (cell, thin film surface, etc.). Many measurement setups at the micrometer level and with nanometer precision have been designed for quantitative surface determination. Among these, white light diffraction phase microscopy (WDPM) is a design that combines the advantages of off-axis holography-specific speed and phase sensitivity associated with common path interferometry. Interferogram image of RBCs have been formed by the WDPM setup. Analysis of this image has been carried out by Fourier transform. As a result of this analysis, three-dimensional (3D), dynamic (observable from all angles) and height-known profiles of RBCs have been created. From the height profiles, the parameters related to the morphology of RBCs as the projected surface area (PSA), diameter (D), mean corpuscular volume (MCV) and total surface area occupied by the cell (SA), have been determined quantitatively. In addition, two-dimensional images,
obtained by examining blood samples with light microscopy and scanning electron microscopy (SEM), have been compared with the data achieved by WDPM. The advantages and disadvantages of WDPM and light microscopy and SEM, which are commonly used in biomedical measurements, are discussed through the results. In this way, it was possible to see the difference between QPI and traditional methods used to imaging the cell surface.
The Importance of Good Governance in the Government Organization
Authors: Karunia R. Luki , Darmawansyah Darmawansyah , Dewi Kurnia Sari , Prasetyo Johan Hendri
Published: May 2023

The intention of this research was to evaluate the influence of the implementation of good governance on the performance of one of the government organizations. The method used was a quantitative-descriptive with causality approach, which was then analyzed by PLS-SEM. The amount of the research sample was 303 of state civil apparatus at the Land Transportation Management Center throughout 38 provinces in Indonesia. The research findings explained that transparency has an impact on the increasing accountability and responsibility of government organizations but has no power to boost their performance. Accountability has an influence on increasing responsibility and the performance of an organization. Responsibility is also found to be effective in rebuilding the performance of government organizations. This research brings the latest issue to the surface. By linking all indicators of good governance factors, namely transparency-accountability, transparency-responsibility, and accountability-responsibility, which is rarely done in previous research that focused on the connection between good governance-performance. In addition to that, this research was also conducted at the Land Transportation Management Center throughout 38 provinces, so the level of accuracy would be high and had a huge impact on related government organizations in Indonesia. Doi: 10.28991/HIJ-2023-04-01-06 Full Text: PDF
THE PHENOMENON OF THE TRANS-REGIONAL MEGAPROJECTS AND THEIR INFLUENCE ON THE ECONOMIC INTEGRATION
Authors:   Russian State University for the Humanities, Sopilko Natal’ya Yu. , Potapov Daniil A. ,   Plekhanov Russian University of Economics
Published: May 2023

The article is about the conceptualization of the trans-regional mega-project phenomenon by the examples of China’s initiative “One Belt – One Road”, the EU “Global Gateway” and Japan “Free and Open Indo-Pacific” through the following theoretical approaches: neo-functional integration theory, spatial approach, the concept of global value chains. The neo-functional theory of integration and the phenomenon of “Haas spill-over” are used for assessing the integration potential of trans-regional megaprojects. The main features of the trans-regional megaprojects are distinguished through the comparison of trans-regional partnerships and megaprojects. The influence of trans-regional megaprojects on global value chains is evaluated by the examples of industrial and investment projects implemented within the framework of “One Belt, One Road”, “Global Gateway” and Japan’s Strategy “Free and Open Indo-Pacific Region”.
Analysis of Leonardo Da Vinci's Work “The Last Supper” in the Context of Iconographic Analysis
Authors: KARAKAYA Fatih , GÜNEŞ Doğan
Published: May 2023

Özet Milano Dükü Ludovico Sforza’nın, 1495 yılında Santa Maria Dele Grazie kilisesi duvarına yapılması için Rönesans’ın önemli sanatçılarından Leonardo Da Vinci’ ye sipariş verdiği "Son Akşam Yemeği" tablosu; İsa’nın çarmıha gerilmeden
önce havarileriyle paylaştığı anın betimlendiği sadece döneminin önemli bir sanat eseri değil, bunun yanı sıra insanlık tarihi bağlamında enigmatik yapısıyla her dönem merak ve ilgi uyandıran önemli bir yapıt olmuştur. Erwin Panofsky’nin
20. yüz yılın ilk dönemlerinde yoğun çalışmaları sonrasında ortaya koyduğu sanat eseri çözümleme yöntemlerinden ikonografi ve ikonoloji, sanat tarihi için ehemmiyetli bir konuma sahiptir. Toplamda üç bölümden oluşan bu yöntemin
ilk kısmını “doğal konu”, ikinci kısmını “danışıklı konu” ve üçüncü kısmını ise içsel anlam olarak tanımlanan “içerik” kısmı oluşturmaktadır. İkonografik çözümlemede özellikle biçimin analizi için olayın geçtiği dönemin özelliklerinin
göz önünde bulundurularak anlaşılması, en ince ayrıntısına kadar sorgulanması ve yorumlanmasıdır. Bu çalışma ile sanat eserinin oluştuğu dönemin kültürel nitelikleri, sanatçının üslubunu ve kültürel ortamın sanat yapıtına katkısını
belirlemek amaçlanmıştır.
Problemas y soluciones de la Educación Superior en América del Sur Monografia Dr. Sergio Grunbaum...
Authors: Grunbaum Dr. Sergio
Published: May 2023

Abstract
La educación superior en América del Sur se enfrenta a varios desafíos que afectan su calidad y accesibilidad. Los principales problemas incluyen la falta de financiamiento adecuado, la falta de acceso a recursos educativos de alta calidad, la baja retención estudiantil y la falta de relevancia de los programas de estudio para las necesidades del mercado laboral.
Para abordar estos desafíos, se han implementado varias soluciones. Algunas soluciones incluyen la creación de sistemas de becas y préstamos para estudiantes de bajos ingresos, la promoción de la colaboración entre universidades y empresas para desarrollar programas de estudio más relevantes y la implementación de tecnología educativa para mejorar la accesibilidad a recursos educativos de alta calidad.
Además, también se están promoviendo políticas que fomentan la diversidad y la inclusión en las instituciones de educación superior, lo que ayuda a mejorar la equidad y la justicia social. Estas políticas incluyen la implementación de cuotas para grupos minoritarios y la creación de programas de tutoría y apoyo para estudiantes de bajos ingresos.
En resumen, aunque la educación superior en América del Sur enfrenta desafíos significativos, hay soluciones en marcha para mejorar su calidad y accesibilidad. La implementación de estas soluciones debería ayudar a mejorar la equidad y la justicia social, así como también mejorar la calidad de vida y las oportunidades económicas de los estudiantes de la región.
TIDieR Placebo A guide and checklist for reporting placebo and sham controls
Authors: Grunbaum Dr. Sergio
Published: May 2023

Abstract
Background
Placebo or sham controls are the standard against which the benefits and harms of many active interventions are measured. Whilst the components and the method of their delivery have been shown to affect study outcomes, placebo and sham controls are rarely reported and often not matched to those of the active comparator. This can influence how beneficial or harmful the active intervention appears to be. Without adequate descriptions of placebo or sham controls, it is difficult to interpret results about the benefits and harms of active interventions within placebo-controlled trials. To overcome this problem, we developed a checklist and guide for reporting placebo or sham interventions.
Methods and findings
We developed an initial list of items for the checklist by surveying experts in placebo research (n = 14). Because of the diverse contexts in which placebo or sham treatments are used in clinical research, we consulted experts in trials of drugs, surgery, physiotherapy, acupuncture, and psychological interventions. We then used a multistage online Delphi process with 53 participants to determine which items were deemed to be essential. We next convened a group of experts and stakeholders (n = 16). Our main output was a modification of the existing Template for Intervention Description and Replication (TIDieR) checklist; this allows the key features of both active interventions and placebo or sham controls to be concisely summarised by researchers. The main differences between TIDieR-Placebo and the original TIDieR are the explicit requirement to describe the setting (i.e., features of the physical environment that go beyond geographic location), the need to report whether blinding was successful (when this was measured), and the need to present the description of placebo components alongside those of the active comparator.
Conclusions
We encourage TIDieR-Placebo to be used alongside TIDieR to assist the reporting of placebo or sham components and the trials in which they are used.
Viktor Yakovlevich Bulokhov: a person and a scientist (to the 90th anniversary of the birth)
Authors: Spiridonova G. S. , Yudenko Yu. R.
Published: May 2023

The article aims to comprehend the methodological legacy of Viktor Yakovlevich Bulokhov (1933–2022), a doctor of pedagogical sciences, professor, prominent Russian scientist. The paper briefly highlights the biography of the researcher. Analysing the main writings of V. Ya. Bulokhov, we identify the key areas of his scientific research, present the most significant conclusions, and evaluate their practical significance. It is emphasised that V. Ya. Bulokhov considered the issues of methodology from a psycholinguistics perspective, i. e. in light of the theory of speech activity. Many methodological solutions the scientist proposed are radical, sometimes unexpected, but always theoretically substantiated and experimentally confirmed. It is concluded that they have not lost their relevance so far. They deserve a thorough examination and ought to be consistently applied in modern school practice.
Linguoculturological analysis as the backbone of a value-based Russian language lesson
Authors: Levushkina O. N.
Published: May 2023

The relevance of the article is due to the need to provide spiritual and moral education while teaching the Russian language. The study aims to prove that a value-based lesson is the most popular type of a Russian language lesson in the modern educational paradigm. Another purpose of the paper is to show the connection between its methodology with linguoculturology as well as the opportunities for forming a system of spiritual and moral values in students. These goals are the rationale for employing such research methods as an analysis of linguistic, linguoculturological and methodological concepts in conjunction with generalisation of the obtained results. Additionally, the study relies on modelling a methodological system. Such a system exploits the linguoculturological potential of the word and the text for developing schoolchildren spiritually and morally in the process of teaching Russian. The paper outlines the most promising linguoculturological areas which are being developed in modern methodological science. These are methodological linguoconceptology and methodological text linguoculturology. Within the framework of the former, the dominant approach is studying the word as a concept of culture. Methodological linguoconceptology has developed such methodological tools as a linguoculturological portrait of the word, linguoculturological problems, and linguoconceptocentric essays. In addition, lessons-concepts (i. e. integrated lessons of transdisciplinary concept portrayal) have been described. Within the methodological text linguoculturology framework, I systematise information about the linguoculturological characteristics of the text. As a result, exploring the text as a coherent unit of language, speech, and culture is enabled. The research also demonstrates the versatility of this methodological tool. The methodology of linguoculturological text characterisation underlies the innovative lesson type, i. e. the text laboratory or laboratory-based work with texts. The main results of the study are the proposed definition of a value-based Russian language lesson and the description of its key features. The paper convincingly demonstrates the decisive role of linguoculturological word and text analysis in a value-based Russian language lesson. I propose a typology of value-based Russian language lessons depending on the subject matter of linguoculturological analysis. Three types have been identified: logocentric, text-centric, and combined. Linguoculturological analysis as the backbone of a value-based lesson enables teachers to combine most complex processes of language learning and culture acquisition as well as forming a world view and developing a system of values in students.
The heart does not sink or Runglish in modern Russia
Authors: Ilchenko О. S.
Published: May 2023

The article raises sociolinguistic and cognitive issues of the interaction between the Russian and English languages in modern Russia. The study aims to show how blending of two different language codes affects thinking, consciousness, culture, the spiritual state of individuals and the entire nation. The article highlights objective and subjective factors contributing to the emergence of a hybrid language or the so-called Runglish. I identify the stimuli motivating Russian speakers to use it. The paper draws attention to the lack of conditions in modern Russian society for forming a protective speech culture mechanism, i. e. a native speaker’s intuition. The research shows how linguistic norms (including grammar) are being loosened; the distinctions between the literary language and jargons are being erased. The illustrative material reflects typical cases of usage. The paper sets vitally important objectives of preserving and protecting the Russian literary language, the emotive and cultural code of the Russian nation as well as the revival of the Russian mentality (thinking in language forms). I emphasise the need for a circumspect language policy, awareness raising, and responsibility of Russian public figures. The study applies cognitive, contextual, comparative, lexical-etymological, word-formation, and grammatical analysis.
From Italian to Russian with the Superpower of Intercomprehension
Inference in Graphical Decoding Across Different Alphabets
Authors: Ilina Anna
Published: May 2023

Intercomprehension is the ability to understand a language that is related to an already familiar one. It is based on the activation of previous knowledge and cognitive strategies, such as inference. In this article, we claim that intercomprehensive reasoning can also be applied across European linguistic families. We argue that by creating didactic materials based on the fundamentals of the intercomprehensive approach, it is possible to leverage the students’ natural ability for intercomprehension when approaching a completely unfamiliar language of Europe. In particular, we study if inference can be applied to graphical decoding of familiar and authentic words in an unfamiliar European language with a different alphabet. A small-scale empirical study conducted in Rome with Italian speakers shows that they were able to autonomously decipher the Russian alphabet through a specifically created task.
Alternative clinical approaches to the treatment of pruritus related with canine atopic dermatitis
Authors: TELCİ Deniz Zeynep , İZMİRLİ Semih , OR M. Erman , DOKUZEYLÜL Banu
Published: May 2023

Canine atopic dermatitis (CAD) is a genetically inheritable, inflammatory and pruritic skin disease with characteristic clinical features, most commonly associated with IgE antibodies to environmental allergens. Itching is the most prominent clinical finding. Depending on the allergens involved, seasonal or non-seasonal pruritus may occur.

In the first active phase of pruritus treatment, which consists of two stages, acute exacerbations should be controlled by drugs with active ingredients such as corticosteroids, oclacitinib, lokivetmab, etc. In the proactive pruritus treatment, it is aimed to prevent exacerbations and prolong the pruritus-free period with maintenance treatment. For this purpose, in addition to active phase of the therapy, different treatment options such as cyclosporine, tacrolimus, antihistamines, essential fatty acids, Palmitoylethanolamide (PEA), topical drugs and shampoos can be used to repair the skin barrier.

Due to the side effects and costs of the drugs used in the treatment of pruritus in atopic dermatitis, researches on alternative treatment methods are still continuing. Applications such as mesenchymal stem cell therapy, recombinant canine gamma-interferon, luteolin, vitamin D, vitamin E, lactoferricin/verbascoside, mastinib, cannabidiol (CBD), probiotics and vaccination against IL-31 are the alternative treatment options for atopic dermatitis in dogs. However, more studies are needed before their inclusion in our routine clinical practices and added to the guidelines. In this review, it is aimed to provide information about new treatments used for pruritus in CAD and to encourage their use in routine veterinary clinical practice.