bluuebunny/crossref_metadata_2025 huggingface dataset:
ANALISIS IMPLEMENTASI PENDIDIKAN KARAKTER DALAM PENINGKATAN KEMANDIRIAN BELAJAR SISWA KELAS V DI SD NEGERI 1 ADIKARSO TAHUN AJARAN 2020/2021
Authors: Syahrizal Fadli , Suhartono Suhartono , Rokhmaniyah Rokhmaniyah
Published: August 2022

Abstract

The study aimed to describe the implementation of character education in improving the independence in learning to fifth grade students of SD Negeri 1 Adikarso in academic year of 2020/2021. It was a qualitative study method with a case study approach. The results indicated that: first, the implementation of character education in improving the independence in learning to fifth grade students of SD Negeri 1 Adikarso ran well. Second, the implication of character education in improving the independence in learning to fifth grade students of SD Negeri 1 Adikarso had been carried out well by the majority of students. Third, there were obstacles and efforts in the implementation of character education in improving the independence in learning to fifth grade students of SD Negeri 1 Adikarso. It concludes that the implementation of character education in improving the independence in learning to fifth grade students of SD Negeri 1 Adikarso works well. The implementation of character education finds obstacles but those have been handled by the teacher. 

Keywords: Implementation, character education, independence in learning
PENERAPAN MODEL PEMBELAJARAN VISUALIZATION, AUDITORI, KINESTETIK DALAM PENINGKATAN HASIL BELAJAR SBdP TENTANG KARYA SENI KOLASE PADA SISWA KELAS IV SD NEGERI 2 KECILA TAHUN AJARAN 2020/2021.
Authors: Nuresti Dyah Anis , Susiani Tri Saptuti , Wahyudi Wahyudi
Published: August 2022

Abstract :

The purpose of this study was to improve SBdP learning outcomes about collage art for fourth grade students with the Visualization Auditory Kinesthetic model. This research is a collaborative classroom action research carried out in three cycles, each cycle consisting of planning, implementation, observation, and reflection. The subjects of this study were grade IV students of the State Elementary School 2 Kecila for the 2020/2021 academic year, totaling 20 students. The data obtained come from teachers and students with observation, interview, and test data collection techniques. Data validity using triangulation technique with qualitative and quantitative analysis techniques. The results showed an increase in collage learning with the Visualization Auditory Kinesthetic learning model, the percentage of learning completeness in the first cycle was 52.50%, the second cycle was 70.00% and the third cycle was 87.50%. It can be concluded that the application of the Visualization Auditory Kinesthetic model can improve the learning of Cultural Arts and Crafts about the fourth grade collage of the State Elementary School 2 Kecila for the 2020/2021 Academic Year.

 

 

Abstrak :

Tujuan penelitian ini adalah meningkatkan hasil belajar SBdP tentang karya seni kolase pada siswa kelas IV dengan model Visualization Auditory Kinesthetic.Penelitian ini merupakan penelitian tindakan kelas kolaboratif dilaksanakan dalam tiga siklus, setiap siklus terdiri dari perencanaan, pelaksanaan, observasi, dan refleksi. Subjek penelitian ini adalah siswa kelas IV Sekolah Dasar  Negeri 2 Kecila Tahun Ajaran 2020/2021 yang berjumlah 20 siswa. Data yang diperoleh bersumber dari guru dan siswa dengan teknik pengumpulan data secara observasi, wawancara dan tes. Validitas data menggunakan teknik triangulasi dengan teknik analisis secara kualitatif dan kuantitatif. Hasil penelitian menunjukkan terjadi peningkatan pembelajaran kolase dengan model pembelajaran Visualization Auditory Kinesthetic, persentase ketuntasan belajar siklus I 52,50%, siklus II 70,00% dan pada siklus III 87,50%. Dapat disimpulkan bahwa penerapan model Visualization Auditory Kinesthetic dapat meningkatkan pembelajaran Seni Budaya dan Prakarya tentang kolase kelas IV Sekolah Dasar Negeri 2 Kecila Tahun  Ajaran 2020/2021.

 
Peningkatan Hasil Belajar Matematika materi Pengukuran Sudut Melalui Model Pembelajaran Problem Based Learning (PBL) di Kelas IV SDN Bandung Tahun Ajaran 2020/2021
Authors: Ardiyanto Pulung , Wahyudi Wahyudi , Suhartono Suhartono
Published: August 2022

Abstract

Learning outcomes are crucial as the indication if learning process is succeed or failure.  The study aimed to improve the mathematics learning outcomes about Angle Measurement through the Problem Based Learning (PBL). It was collaborative classroom action research (CAR) conducted in three cycles. The subjects were teachers and 18 fourth grade students of SDN Bandung. Data collection techniques used non-test techniques including observation, interviews, documents, and test. The data validity used triangulation of techniques and triangulation of sources. Data analysis techniques included data reduction, data presentation, and drawing conclusions. The results indicated that the students’ mathematics learning outcomes increased after applying Problem Based Learning (PBL). It concludes that the application of Problem Based Learning (PBL) improves the mathematics learning outcomes about angle measurement.
Analisis Implementasi Nilai Karakter Melalui Layanan Home Visit pada Tema Udara Bersih bagi Kesehatan Siswa Kelas V SDN Sidototo Tahun Ajaran 2021/2022
Authors: Kamsiyatun Siti , Ngatman Ngatman , Rokhmaniyah Rokhmaniyah
Published: August 2022

Abstract

 

The study aimed to describe: the implementation of character values through home visit services, the obstacles, and the effort to deal with obstacles in implementing character values through home visit services in the theme of Fresh Air for Health to fifth grade students of SD Negeri Sidototo. It was qualitative method. The subjects were teachers and students of fifth grade. The results indicated that character values consisted of tolerance, disipline, honest, responsibility, environmental concern, curiosity, hard work, communication, cooperation, and perseverance. The home visit service applied the following aspects such as volunteerism, open-minded, activity, independence, dynamics, cohesiveness, normativity, and contemporary. The obstacles in implementing character values through home visit were the student’houses were far from the place for home visit activities, the students did not go to the home visit to study for various reasons, the students were jealous since their houses were not used as a place for home visit, the students had limited transportation, the learning facilities at the home visit were limited, and the students were pivky in making friends. The teachers made appropriate efforts to overcome the obstacles in implementing character values through home visit services.
Hubungan antara Disisplin Belajar dan Motivasi Belajar dengan Hasil Belajar PPKn Siswa SDN se-Kecamatan Banjarnegara Tahun Ajaran 2021/2022
Authors: Dewi Rachma Mutiara , Chamdani Muhammad , Ngatman Ngatman
Published: August 2022

Abstract

The study aimed to prove that there was the positive correlation between learning discipline and learning motivation on Pancasila and Civic Education learning outcomes to fourth grade students of public elementary schools in Banjarnegara Sub-district in academic year of 2021/2022. The population were 804 fourth grade students and the samples were 363 fourth grade students. Data collection techniques used questionnaires and tests. The validity method included question analysis using Pearson correlation analysis. Reliability used the Alpha (Cronbach’s) formula. The prerequisite test used normality test, linearity test, and multicollinearity test. Data analysis techniques used multiple correlation analysis. The result indicated that the correlation value between learning discipline and learning motivation was 0.570 on Pancasila and Civic Education learning outcomes. The significant value was 0.000 less than 0.5.
Factors influencing absorption of the banks' financial resources: assessment of the optimality
Authors:   Belgorod National Research University, Stryabkova Elena , Chistnikova Irina ,   Belgorod National Research University, Antonova Marina ,   Belgorod National Research University, Druzhnikovа Elena ,   Belgorod National Research University, Mochalova Yana Veklich ,   Belgorod National Research University
Published: August 2022

Optimal allocation of deposits (resources) and facilities (expenditures) are among the most important strategies of banks. Optimal allocation of resources in various economic sectors leads to targeting of funds collected by banks. Optimal allocation of expenses, in addition to obtaining returns in excess of the cost of attracting resources, leads to rapid and timely response to bank customers. The purpose of this study is to provide linear programming models to determine the optimal combination of resources and expenditures of banks with the approach of reducing the cost of money. The tools used in this research are linear programming models and the data used is quantitative. The results of this study showed that all five factors (electronic banking, physical factors and conditions, service factors, communication and human factors and financial factors, respectively) were effective factors in attracting resources. They are influential in the bank, respectively.
ANALISIS KESTABILAN MODEL SVIQR PADA PENYEBARAN PENYAKIT TUBERKULOSIS
Authors: Else As Syavira  , Embay Rohaeti  , Ani Andriyati
Published: August 2022

Tuberkulosis merupakan penyakit menular yang disebabkan oleh bakteri Mycobacterium tuberculosis. Permasalahan tuberkulosis masih menjadi masalah yang membutuhkan perhatian dari pemerintah. Model SVIQR (Suspectible, Vaccinated, Infected, Quarantined, Recovered) merupakan model yang menggambarkan penyebaran penyakit tuberkulosis dengan kondisi adanya vaksinasi yang dilakukan pada individu rentan dan adanya karantina berupa rawat inap pada individu yang telah dinyatakan terinfeksi. Pada penulisan ini akan dibahas kestabilan titik tetap yang terdapat dalam model SVIQR, analisis kestabilan dilakukan dengan mencari titik tetap yang menghasilkan dua titik tetap selanjutnya titik tetap tersebut dianalisis kestabilannya dengan kriteria Routh-Hurwitz. Berdasarkan analisis kestabilan titik tetap dengan kriteria Routh-Hurwitz dihasilkan bahwa titik tetap pertama stabil pada saat penyakit tuberkulosis tidak mewabah dan tititk tetap kedua stabil pada saat penyakit tuberkulosis mewabah.
Braille Innovation Technology in Teaching and Learning Process For Visual Impairment
Authors: Tisnawati Nur Fadhilah , Yuliati  , Endang Purbaningrum
Published: August 2022

The innovation of braille makes learning for children with visual impairments easier. The breakthrough braille innovation developed is able to encourage the creation of creative, active, and practical learning for children with visual impairments. This study aims to collect and analyze articles related to innovation technology of braille for teaching and learning process to visual impairment. The design of study used literature review that use data collection methods with search related topics, data analysis and also writing research results. The results of this study that braille innovations technology for reading, writing and conceptualizing of reading are useful in the learning process of children with visual impairments.
Feedback in The Learning Process on Indonesian Master’s Degree Experience Studying Abroad
Authors: Muhammad Hidayat  , Saleh M Nurul Ikhsan
Published: August 2022

Studies on the perception of Indonesian master’s degree students from various universities abroad on satisfaction with feedback in the learning process are still limited. This study aims to explore the perceptions of college students related to feedback and how the feedback enables students to sharpen and improve practical skills in the learning process. Researchers in this study uses a case study method included in qualitative research. Researchers interviewed 32 participants who were selected using the snowball sampling technique which consisted of master degree students from four countries: Indonesia, the United Kingdom, the United States of America, and Australia. The questions in this study focused on responses to various types of feedback based on the question and delivery, student expectations, and how feedback affects academic performance. This study found four major themes, namely the importance of being explicit in providing feedback, variations in giving feedback, comprehensive feedback students expect for lecturers in Indonesia, and using feedback to improve students’ academic performance.
Interactive Media Applications as Learning Aids for Food Preservation Practice Courses for Deaf Vocational Students
Authors: Lina Mufidah  , Rachmawati Eka , Sulistyani Titik
Published: August 2022

This study aims to develop an interactive learning application that helps in providing direction on food preservation practices which are then expected to be a means of delivering material using video tutorials, text and equipped with sign language interpreter videos so that learning becomes more communicative for deaf students. The research method used in this study is the Research and Development (R&D) method. The development procedure used in this research is the Luther-Sutopo method. Subjects in this study focused on deaf students who took food preservation courses. The form of the instrument used in this research is a questionnaire. The results of the study show that at stage The results of the study show that at stage (1) The interactive learning application can help in providing direction on food preservation practices for deaf students. This application contains a means of delivering material in the form of learning tutorial videos equipped with text and added with translator videos using sign language. This application is declared feasible in all aspects either by media experts or deaf students. (2) The results of application trials from media experts obtained the most in the aspect of assessing media integration. The results of the trial obtained from deaf students obtained the highest score was on the artistic and aesthetic aspects and on the aspects of overall functioning.
Augmented Reality Visualization through Multirepresentations Approach in Chemistry Based on Qur’anic to Improve Cognitive Learning Outcomes
Authors: Rizal Ramadhan Mochammad , Najib Fahmi M. Iqbal , Mutiara Hasanah Samudra
Published: August 2022

media melalui visualisasi augmented reality berbasis pembelajaran al-Qur'an, dan mengkaji sejauh mana hasil belajar siswa yang menggunakan media tersebut. Untuk mewujudkan tujuan tersebut, pendekatan ADDIE (Analisis, Desain, Pengembangan, Implementasi, dan Evaluasi) digunakan untuk mengembangkan media. Berdasarkan temuan penelitian, media yang dikembangkan berupa buku berbasis smartphone dan berhasil divalidasi relevansinya oleh ahli media, ahli materi, guru, peer reviewer, dan siswa. Secara khusus, validasi mengungkapkan (1) 87,27% untuk relevansi produk; (2) 90,66% untuk materi IPA Al-Qur'an; (3) 82,85% untuk tanggapan peer reviewer dan guru; dan (4) 86,2% untuk respon siswa, khususnya pada materi multirepresentasi kimia (tingkat makroskopis, submikroskopis, dan simbolik). Implementasi yang dilakukan terhadap 100 siswa, menunjukkan bahwa media pembelajaran berpengaruh positif dan meningkatkan motivasi siswa dalam pembelajaran al-Qur'an dan kimia. Selain itu, berdasarkan hasil uji coba pretest dan posttest menggunakan analisis paired sample t-test terhadap 50 siswa diperoleh nilai signifikansi sebesar 0,000. Hal ini menunjukkan bahwa media pembelajaran ini terbukti mampu meningkatkan hasil belajar kognitif siswa.
Development of Website-Based Statistics Learning Videos
Authors: Dewi Juliah Ratnaningsih  , Hasanah Siti Hadijah
Published: August 2022

One source of learning in the learning process is learning materials. In distance education, learning resources prepared for students must be able to be studied independently. The separation of lecturers and students needs to be bridged by learning materials that can be understood by students. A video is a form of learning materials that can be used to help students understand the material. Through videos, students can learn anywhere and anytime according to the time available. In the video, the duration of the material delivery is very significant. Likewise, components such as intro, greeting, and outro greatly support student motivation. The effective video duration in learning website-based statistical data analysis is 10-15 minutes. The component of presenting material that is in great demand by students in the discussion of sample questions and their application using R software.
Development of Mathematics Teaching Materials to Improve Higher Order Thinking Skills in Grade 3rd Students in Elementary School
Authors: Ratnawati Wahyu , Sutama  , Sabar Narimo
Published: August 2022

Mathematics learning in elementary schools is not fully oriented to higher order thinking skills (HOTS). In fact, HOTS play an important role in solving mathematical problems so that they require the support of effective teaching materials. The purpose of this study was to develop mathematics teaching materials to improve HOTS in grade 3 elementary school students. This research is a development research using the Borg & Gall model. The stages of this research consist of information gathering, development planning, product draft development, and initial product testing. Research data obtained through questionnaires and tests. The data were then analyzed using an interactive model consisting of data condensation, data presentation, and drawing conclusions. The results showed that the product assessment results from material experts were 88.09, media experts were 92.00, linguists were 92.30, and practitioners were 92.24. Considering the results of the validation assessment from several experts, it can be concluded that the mathematics teaching materials developed have been feasible to improve HOTS in grade 3 elementary school students. The development of 3D-based mathematics teaching materials on two-dimentional figure provides assistance for students in solving problems more realistically and easily. Book products are not only in the form of pictures but can be seen, folded or rotated so that they can develop students' thinking in analyzing, evaluating and creating which are adapted to the context of solving mathematical problems in elementary schools.
Arthroscopic-Assisted Percutaneous Fixation of a Femoral Head Fracture (Pipkin II)
Authors: Rojas-Sayol Roger , De Caso J. , Valera M.
Published: August 2022

Case:

Fractures of the femoral head are infrequent injuries with potentially devastating complications. Pipkin type II fractures often require surgical fixation. It involves intraarticular approaches that may increase the inherent morbidity of these fractures. Hip arthroscopy minimizes surgical aggression and allows for direct control of fracture reduction. We present a case report of an arthroscopic-assisted percutaneous fixation of a Pipkin-II femoral head fracture. A hip arthroscopy without traction and percutaneous screw fixation was conducted under arthroscopic and fluoroscopic guidance.

Conclusion:

Arthroscopic-assisted percutaneous fixation is a useful technique for optimal femoral head fracture treatment and may also minimize surgical morbidity and optimize early recovery.
An Integration Method of Bursting Strain Energy and Seismic Velocity Tomography for Coal Burst Hazard Assessment
Authors: Bai Jinzheng , Dou Linming , Cai Wu , Gong Siyuan , Shen Wei , Tian Xinyuan , Ma Hongjun
Published: August 2022

The occurrence of coal burst in underground coal mines is complex, abrupt, and diverse, and the evaluation and prediction of coal burst hazard is the premise of effective prevention and control of coal burst. In this study, a coal burst carrier system model under the synergistic action of roof, coal seams, and floor was established, and the evolution of coal burst in underground coal mines was discussed based on the stress-vibration-energy coupling principle. On this basis, an integration method of bursting strain energy and seismic velocity tomography for coal burst assessment was proposed. With the deep and complex panel in a mine as the research object, the coal burst risk of the panel during excavation was evaluated in time and space domains, respectively. Results showed that the bursting strain energy and the active seismic velocity tomography technology can accurately identify both the positive anomalies and the negative anomalies of stress field and energy field in the mining period. Moreover, the method can not only evaluate the coal burst risk of the panel in the temporal domain but also predict the area with potential strong seismic events in the spatial domain. The research conclusions can accurately illustrate the whole complex evolution process of coal burst in underground coal mines.
A standardised pre-clinical in-vitro blood-brain barrier mouse assay validates endocytosis dependent antibody transcytosis using transferrin receptor-mediated pathways.
Authors: Morrison Jamie I. , Petrovic Alex , Metzendorf Nicole G. , Rofo Fadi , Yilmaz Canan U. , Stenler Sofia , Laudon Hanna , Hultqvist Greta
Published: August 2022

The presence of the blood brain barrier (BBB) creates a nigh on impenetrable obstacle for large macromolecular therapeutics that need to be delivered to the brain milieu to treat neurological disorders. To overcome this, one of the strategies used is to bypass the barrier with what is referred to as a “Trojan Horse” strategy, where therapeutics are designed to use endogenous receptor-mediated pathways to piggyback their way through the BBB. Even though in vivo methodologies are commonly used to test the efficacy of BBB penetrating biologics, comparable in vitro BBB models are in high demand, as they benefit from being an isolated cellular system devoid of physiological factors that can on occasion mask the processes behind BBB transport via transcytosis. We have developed an in vitro BBB model (In-Cell BBB-Trans assay) based on the murine cEND cells that helps delineate the ability of modified large bivalent IgG antibodies, conjugated to the transferrin-receptor binder scFv8D3, to cross an endothelial monolayer grown on porous cell culture inserts (PCIs). Following the administrating of bivalent antibodies to the endothelial monolayer, a highly sensitive ELISA method is used to determine the concentration in the apical (blood) and basolateral (brain) chambers of the PCI system, allowing for the evaluation of apical recycling and basolateral transcytosis respectively. Our results show that antibodies conjugated to scFv8D3 transcytose at considerably higher levels compared to unconjugated antibodies in the In-Cell BBB-Trans assay. Interestingly, we are able to show that these results mimic in vivo brain uptake studies using identical antibodies. In addition, we are able to transversely section PCI cultured cells, allowing for the identification of biomarkers pertinent to transcytosis of the antibodies. Furthermore, studies using the In-Cell BBB-Trans assay revealed transcytosis of the transferrin-receptor targeting antibodies is dependent on endocytosis. In conclusion, we have designed a simple, reproducible In-Cell BBB-Trans assay based on murine cells that can be used to rapidly determine the BBB penetrating capabilities of transferrin-receptor targeting antibodies. We believe the In-Cell BBB-Trans assay can be used as a powerful, pre-clinical screening platform for therapeutic neurological pathologies.
Lack of evidence for fentanyl as the optimal opioid for critically ill patients on mechanical ventilation: a systematic review and meta-analysis
Authors: Aoki Yoshitaka , Kato Hiromi , Fujimura Naoyuki , Suzuki Yuji , Sakuraya Masaaki , Doi Matsuyuki
Published: August 2022

Background: Fentanyl is selected to manage pain in critical care patients in the intensive care unit (ICU). However, the usefulness of fentanyl has not been established. This study examined the evidence for the use of fentanyl to improve the clinical outcomes in ICU patients, using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system.Methods: We searched the MEDLINE, Cochrane Central Register of Controlled Trials, and Igaku Chuo Zasshi databases in June 2021. Two independent assessors reviewed studies to identify randomized, controlled trials that compared the intravenous administration of fentanyl and other opioids in mechanically ventilated patients. The study quality was assessed using the GRADE system and Cochrane methodology. The primary outcome was mortality. Secondary outcomes were the duration of mechanical ventilation, duration of the ICU stay, incidence of severe adverse events, and incidence of delirium. We integrated outcome data using a random-effects model and showed absolute values and certainty of evidence in the GRADE evidence profile.Results: Eleven Randomized Controlled Trials met the study inclusion criteria with 1312 patients (643 were treated with fentanyl and 669 with other opioids, including 628 with remifentanil and 41 with morphine). Among 816 participants from 4 RCTs, fentanyl was not associated with mortality (risk ratio [RR], 0.74; 95% confidence interval [CI], 0.28 to 2.00; low-quality evidence). Regarding the secondary outcomes, fentanyl did not shorten the duration of mechanical ventilation (mean difference [MD], −1.71 h; 95% CI, −3.79 to 0.37; moderate-quality evidence) or the duration of the ICU stay (MD, −1.89 h; 95% CI, −5.00 to 1.22; moderate-quality evidence) compared with other opioids. Fentanyl also did not increase the incidence of severe adverse events (RR, 0.80; 95% CI, 0.56 to 1.15; moderate-quality evidence) or delirium (RR, 1.27; 95% CI, 0.79 to 2.04; low-quality evidence). Conclusions: Although fentanyl is a frequently administered opioid in ICUs worldwide, the current analysis found no evidence to support its clinical use. However, the GRADE evaluation provides little certainty to support the results of this systematic review, and further large RCTs are therefore needed to confirm the conclusions.Trial registration: PROSPERO, CRD42019130648https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=130648
A retrospective study of 18 children with subcutaneous panniculitis-like T-cell lymphoma: Multidrug combination chemotherapy or immunomodulatory therapy?
Authors: Duan Yanlong , Gao Huixia , Zhou Chunju , Jin Ling , Yang Jing , Huang Shuang , Zhang Meng , Zhang Yonghong , Wang Tianyou
Published: August 2022

Background Subcutaneous panniculitis T-cell lymphoma (SPTCL) is a rare, cytotoxic T-cell lymphoma with which some patients have accompanying hemophagocytic syndrome (HPS). There is currently no standard treatment regimen. In the past, the most commonly used treatment was multidrug chemotherapy. In contrast, numerous case reports or small series suggest that immunosuppressive drugs could also be effective for some patients. Since this NHL subtype is extremely rare in children and adolescents, to improve the understanding of this disease and standardize its rational treatment, we retrospectively summarized the treatment regimens of 18 pathologically diagnosed children with SPTCL to compare the clinical efficacy of multidrug chemotherapy and immunomodulatory therapy.Results The male to female ratio was 1:5. The median age of onset was 11.1 years. Painless subcutaneous nodules or skin patchy lesions were found in all patients, most commonly involving the lower extremities and/or trunk. The pathology and immunophenotype results of all patients were consistent with SPTCL, and atypical lymphocytes infiltrated and rounded the lipocytes like rosettes in subcutaneous adipose tissue. Tumor cells showed a cytotoxic immunophenotype of cytotoxic T lymphocytes. There were 7 patients (38.9%) with hemophagocytic syndrome (HPS) and 4/5 screened patients (80%) with positive HAVCR2 gene mutations. Before January 1, 2019, the treatment was mainly chemotherapy, and 10 patients were initially treated with chemotherapy, among whom was one patient who progressed during initial treatment, was voluntarily discharged and was subsequently lost to follow-up, one patient who died of disease progression, and the remaining 8 patients who all achieved sustained remission, with a complete remission (CR) rate of 80% (8/10). Corticosteroids combined with cyclosporine A or ruxolitinib were the most common initial immunosuppressive agents at our center after January 1, 2019 and had a CR rate of 71.4% (5/7). In addition, 1 patient achieved partial remission (PR) during follow-up, and one had autologous hematopoietic stem cell transplantation (AHSCT) after 4 months of drug withdrawal. The median follow-up was 17 months. Conclusion The incidence of SPTCL is extremely low, but its prognosis is relatively good. Immunoregulatory therapy can be considered a first-line treatment.
A Life-course Approach to Depression among Middle-aged and Elderly in India: Evidence from the Longitudinal Aging Study in India - 2018-2019
Authors: . Farheen , Dixit Priyanka
Published: August 2022

Background
Depression is a major public health concern in India contributing significantly to morbidity, dysfunction, reduced quality of life, and economic loss. Evidence from previous studies suggest that risk to developing mental illness begins in the early years of life. Thus, we aim to examine the effect of early life conditions-childhood health status and childhood socioeconomic status on depression later in life and the mediating role of other risk factors along life-course- education, current economic status, chronic physical condition(s), and health behaviours - in the effect of early life conditions on depression later in life.
Methods
We used data from Longitudinal Aging Study in India (2018–2019) to find the association between the possible risk factors, including early life conditions, and depression later in life using logistic regression. The factors that were found to be significantly associated with depression later in life were used in the second step of mediation analysing using Karlson-Holm-Breen method, to examine the role of mediators in the effect of early life conditions on depression later in life.
Results
Childhood health, childhood socioeconomic status, education, current economic status, chronic physical condition(s), and tobacco use were found to be associated with depression later in life. Childhood health directly influences the occurrence of depression later in life and its effect is not mediated by risk factors along life course. On the contrary, the effect of childhood socioeconomic status on depression later in life is at least partially mediated by risk factors along life course- education, current economic status, chronic physical condition(s), experience of depression and tobacco use. The greatest contribution to this mediation is by discrimination, followed by tobacco use and education. Chronic physical condition is also a major contributor but it acts as a suppressor. Furthermore, the childhood health also mediates the influence of early life socioeconomic status on depression later in life.
Conclusions
Our findings demonstrate the pertinence of childhood health in reducing the burden of depression later in life. It also underscores the importance of focussing on risk factors along life course- discrimination, tobacco use, and education, health behaviours- for individuals who belonged to families having low socioeconomic status during childhood, and initiatives to prevent chronic physical conditions particularly among those who did not have adverse socio economic status during childhood in order to reduce the burden of depression among middle-aged and elderly population in India.
Effects of long-term dehydration and quick rehydration on the camel kidney: pathological changes and modulation of the expression of solute carrier proteins and aquaporins
Authors: Damir Hassan Abu , Ali Mahmoud , adem Muna , Amir Naheed , Tariq Saeed , Adeghate Ernest , Greenwood Michael , Lin Panjiao , Gillard Benjamin , Alvira-Iraizoz Fernando , Murphy David , ADEM ABDU
Published: August 2022

The kidney of the one-humped camel has a remarkable capacity to preserve water and solute during extremes of long-term dehydration. We investigated the effects of dehydration and subsequent rehydration on camel kidney morphology at the ultrastructural level and the expression of aquaporins and solute carrier proteins. In light microscopy, dehydration induced few degenerative and necrotic changes in cells of the cortical tubules with little effect on medullary cells. Ultrastructural changes were mainly observed in some of the glomerular and tubular cells with insignificant changes in the collecting ducts of medulla. These changes included condensation of nuclear chromatin, vacuolization of cytoplasm, swelling of mitochondria, degradation or loss of brush borders of proximal tubules, cracking of major processes of some podocytes and degeneration of lysosomes and endoplasmic reticulum. Cell death, apoptotic-like bodies and changes in the basolateral membranes were infrequent and nephrolithiasis was not detected. Chronic nephropathy, mainly interstitial fibrosis and glomerular sclerosis induced by recurrent dehydration in human and animal models were not observed. Modulation of SLC proteins, AQP 1, 2, 3, 4, 9 and regulation of gene mRNAs expression levels during dehydration/rehydration play important role in water conservation and cell protection favoring kidney cellular restoration to near normal.
CEGAN: Crystal Edge Graph Attention Network for multiscale classification of materials environment
Authors: Sankaranarayanan Subramanian , Banik Suvo , Dhabal Debdas , Chan Henry , Manna Sukriti , Cherukara Mathew , Molinero Valeria
Published: August 2022

Machine learning models and applications in materials design and discovery typically involve the use of feature representations or “descriptors” followed by a learning algorithm that maps it to a user-desired property of interest. Most popular mathematical formulation-based descriptors are not unique across the atomic environments or suffer from transferability issues across different application domains and/or material classes. In this work, we introduce the Crystal Edge Graph Attention Network (CEGAN) workflow that uses graph attention-based architecture to learn unique feature representations and perform classification of materials across multiple scales (from atomic to mesoscale) and diverse classes ranging from metals, oxides, non-metals and even hierarchical materials such as zeolites. We first demonstrate a case study where the classification is based on a global, structure-level representation such as space group and structural dimensionality (e.g., bulk, clusters, 2D, etc.). Using representative materials such as polycrystals and zeolites, we next demonstrate the transferability of our network in successfully performing local atom level classification tasks, such as grain boundary identification and other heterointerfaces. Finally, we demonstrate classification in (thermal) noisy dynamical environments using a representative example of crystal nucleation and growth of a zeolite polymorph from an amorphous synthesis mixture. Overall, our approach is agnostic to the material type and allows for multiscale classification of features ranging from atomic-scale crystal structures to heterointerfaces to microscale grain boundaries.
Fuzzy and CNN Based Novel approach for Real Time Image De-noising
Authors: mehra rajni , Chaudhary Prahi
Published: August 2022

The discriminative Model for image de-noising has been recently attracting considerable attention due to its favorable de-noising performances. In this paper, a model has been constructed for image de-noising for the standard dataset and real-time dataset. In this paper a novel approach has been implemented known as adaptive fast and flexible de-noising network (AFFDNet). This model is totally based upon the fuzzy and CNN network, with the combination of both image de-noising has been done. Our AFFDNet model is able to capable for handling the different noise level as well as different image sizes. The noise level has been taken 15, 25 & 50 with image size 256*256, 512*512 & 1024*1024. Our model give better result at all noise level also on different size of images. The residual learning is used in this novel approach to remove the latent clean image from hidden layer. In the future scope it can be used in for reduce the complexity because real-time makes algorithm very complex.
BMP-2 Promotes Breast Cancer Metastasis by Inducing EMT via PI3K/Akt Signaling Pathway
Authors: Zhang Li , Shi WeiFeng , Wang Shuling , Wu Yansheng , Tong Zhongsheng
Published: August 2022

Purpose:Bone morphogenetic proteins (BMPs) are important members of the TGF-β superfamily and can be abnormally expressed in various tumors. The purpose of this paper is to investigate the expression of bone morphogenetic proteins-2(BMP-2) in breast cancer and its effects on breast tumor cells and the regulation mechanism.Method:The effects of BMP-2 on the proliferation, cloning, apoptosis, migration and invasion of breast cancer cells were investigated by MTT assay, plate cloning experiment, flow cytometry (FCM), scratch test and transwell assay. The relationship between BMP-2 and epithelial-mesenchymal transition (EMT)-related indicators in cell lines, and the relationship between BMP-2 and PI3K/Akt pathway-related proteins were analyzed using real-time PCR and Western blot. Breast cancer xenograft models were established to observe effects of BMP-2 on the growth and metastasis of xenograft tumors, and real-time PCR and immunohistochemistry were used to detect changes in EMT-related protein expression in xenograft tumors.Results:BMP-2 was highly expressed in MBA-MD-231 and T47D cell lines. The results of in vitro experiments showed that rhBMP-2 could promote the proliferation, colony formation, migration and invasion of breast cancer cells, and reduce the apoptosis ability. The expression of BMP-2 was significantly correlated with EMT. With increasing BMP-2 concentration, the expression of E-cadherin and Cx43 was significantly down-regulated in the epithelial phenotype, while the expression of N-cadherin, fibronectin (FN), and vimentin mRNA was significantly up-regulated in the mesenchymal phenotype. BMP-2 could promote p-PI3K, p-Akt and p-mTOR expression in the PI3K/Akt signaling pathway, which in turn regulated the EMT process. However, after the addition of LY294002, an inhibitor of this signaling pathway, no significant up-regulation of p-PI3K, p-Akt, and p-mTOR was observed, and there was no significant change in EMT-related indicators. Through the establishment of the BMP-2 high expression xenograft model in nude mice, it was found that the growth rate of xenograft in the BMP-2 group was significantly faster than that in the control group, and metastasis to lymph node and bone were likely to occur. Compared with the control group, E-cadherin expression was attenuated and vimentin expression was enhanced in the BMP-2 group, suggesting EMT.Conclusion:BMP-2 is highly expressed in breast cancer tissues and is a malignant regulator of breast cancer cells. Its mechanism of action may be the induction of the EMT via PI3K/Akt pathway. BMP-2 is expected to be a new target for controlling the growth and metastasis of breast cancer.
Design, synthesis, anti-inflammatory evaluation and in silico molecular docking of novel furan-based derivatives with promising TNF-α inhibitory activity
Authors: Bhoge Satish , Singh Prabal P. , Das Deepak K. , Ali Yakub , Dhulap Abhijeet
Published: August 2022

Inflammation is the first response and an alarming signal for onset of chronic disease. Most of the anti-inflammatory drugs available in market are reported to have undesirable gastrointestinal toxicities. Therefore, it is of urgently significance to develop anti-inflammatory drugs with low toxicity and good efficacy. Based on literature survey, we designed a targeted scaffold by condensing distinct structural features of furan and benzyl amides into one pharmacophore. The inspiration for drug design approach of targeted molecule was based on marketed drugs.A series of eighteen furan-based derivatives(1-18)were designed, synthesized forin-vitroandin-vivoanti-inflammatory activity. The characterization of synthesized compounds was elucidated by techniques like 1H-NMR, 13C-NMR, FT-IR and MS. The synthetic compounds were examined through molecular docking studies on TNF-α for probable binding mode and interactions with hydrophilic and hydrophobic pocket of TNF-α in comparison to standard drug (Indomethacin). Compounds 18, 15 and 9 produced comparablein-vitroTNF-α inhibition andin-vivoinflammatory activity when compared to the standard drug along with no damage to stomach and with reduction of LPO. The compounds18, 15and9might be a good consideration for potential anti-inflammatory agents.
A study on the dynamics of pest population with biocontrol using predator, parasite in presence of awareness
Authors: G Suganya , R Senthamarai
Published: August 2022

The coconut tree is often mentioned as the “tree of life” due to its immense benefits to the human community ranging from edible products to building materials. Rugose spiraling whitefly (RSW), a natural enemy seems to be a major threat to farmers in bringing up these coconut trees. A mathematical model to study the dynamics of pest population in presence of predator and parasite is developed. The biologically feasible equilibrium points are derived. Local asymptotic stability as well as global asymptotic stability is analyzed at the points. Furthermore, in order to educate farmers on pest control , we have added the impact of awareness programs in the model. The conditions of existence and stability properties of all feasible steady states of this model are analyzed. The result reveals that predator and parasite plays a major role in reducing the immature pest. It also shows that pest control activities through awareness programs further reduces the mature pest population which decreases the egg laying rate which in turn reduces the immature population.
Religiosity and Spirituality as Agents of Change in Hard Drugs Usage in the Niger Delta area of Nigeria
Authors: Ekeke Emeka C.
Published: August 2022

Drug usage is a global phenomenon that has been seen throughout human history, whether it is done for therapeutic, spiritual, or recreational reasons. Hard drug use and misuse have become a severe concern, especially for those living in Nigeria's Niger Delta, where Christianity is the predominant faith. One can wonder if such a phenomenon should be attributed to the churches' lack of dedication to their religion or if their members have not taken spirituality seriously. In order to explore how religion and spirituality might affect drug use, the current study looks at the usage and abuse of hard and illegal substances in the Niger Delta. The study uses a survey research design and the quantitative research methodology. Responses to closed-ended, structured, electronic and paper-based questionnaires dispersed throughout the study region make up the primary data. The information was gathered both manually and electronically (through email). The study shows that the use of hard drugs is very common in the area and that religious organizations are not doing enough to rehabilitate and treat local drug users on a religious and spiritual level. As the keeper of public morals, the report advises the Church to focus its efforts on preaching against the use and misuse of illegal and hard substances.
Molecular identification of yeasts in oral cavity in immunocompetent teenagers from the North of Mexico
Authors: Rojas Olga C. , Amaral-Montesino Cintia , Mendoza-Olazaran Soraya , González-Álvarez Rafael , Montoya Alexandra M.
Published: August 2022

Human oral cavity is normally colonized for microorganisms including bacteria, fungi, archaea, viruses and protozoa. The aim of this study was to determine the frequency of Candida albicans in de oral cavity in a group of medicine students from the north of Mexico. 240 oral samples from healthy students were analyzed by traditional microbiology cultures and DNA sequencing. 57 samples grew in media cultures. Sequence analysis identified the yeast as follow: 28 Clavispora lusitaniae, 20 Candida albicans, 5 Pichia kudriavzevii and 4 Candida parapsilosis. Our finding revealed that 23.75% of healthy population has a potential pathogen in its mouth. Surprisingly Candida albicans is not the predominant yeast, instead of others non-Candida species are the colonizers of the oral cavity in immunocompetent individuals. Oral cavity is colonized by potential pathogen yeast being Clavispora lusitaniae, Candida albicans, Pichia kudriavzevii and Candida parapsilosis.
Effects of hydrophobic species on the oxygen reduction reaction on the high index planes of Pt3Fe
Authors: Suzuki Akane , Nakamura Masashi , Shimada Haruki , Hoshi Nagahiro
Published: August 2022

Pt3Fe(111), Pt3Fe(775) = 7(111)–(111), and Pt3Fe(544) = 9(111)–(100) electrodes show the highest activity in the low index planes, n(111)–(111), and n(111)–(100) series of Pt3Fe, respectively. The surfaces of these electrodes were modified with hydrophobic species such as THA+, melamine and ionic liquid ([MTBD][beti]), and the effects on the oxygen reduction reaction (ORR) were studied. All the hydrophobic species improved the ORR activity on all the electrodes examined. The ORR activity of Pt3Fe(111) in 0.1 M HClO4 containing 0.1 µM melamine was 2.1 times higher than that of Pt3Fe(111) without melamine, giving 39 times higher activity than that of bare Pt(111). The durability was improved on all the electrodes examined in melamine containing solution.
Health crisis and development deficit: for a common response in Morocco
Authors: Tamsamani Yasser Yeddir
Published: August 2022

The main purpose of this paper is to demonstrate the merits of a joint response in tackling both the health crisis emergency and the development challenges. This joint response involves the establishment of the welfare state in Morocco (part 1). The argument adopted to justify it is based on the theoretical framework established by Michal Kalecki and goes against the precepts of the Washington Consensus and the dominant macroeconomics (the New Synthesis).The credibility of economic policies proposals with regard to the requirements of the welfare state depends on the internal coherence guaranteed by the theoretical framework adopted. It also depends on the capacity to finance these policies: after having demonstrated that the monetization of public debt is not risk free for the Morocco economy, the remain of the second part of the paper will be devoted to the presentation and analysis of three new alternative means of financing the welfare state. These means will allow for the re-establishment of the central role that fiscal policy must play in the country’s development, and the way monetary policy could support it.JEL codes: H1, H6, O1, P16