bluuebunny/crossref_metadata_2025 huggingface dataset:
Elucidation of the Bovine Intramammary Bacteriome and Resistome from healthy cows of Swiss dairy farms in the Canton Tessin
Authors: Romanò Alicia , Ivanovic Ivana , Segessemann Tina , Vazquez Rojo Laura , Widmer Jérôme , Egger Lotti , Dreier Matthias , Sesso Lorenzo , Vaccani Michael , Schuler Martin , Frei Daniel , Frey Juerg , Ahrens Christian H. , Steiner Adrian , Graber Hans Ulrich
Published: July 2023

Healthy, untreated cows of nine dairy herds from the Swiss Canton Tessin were analyzed three times within one year to identify the most abundant species of the intramammary bacteriome. Aseptically collected milk samples were cultured and bacteria identified using MALDI-TOF. Of 256 cows analyzed, 96% were bacteriologically positive and 80% of the 1,024 quarters were positive for at least one bacterial species. 84.5% of the quarters were healthy with somatic cell counts (SCC) < 200,000 cells/mL, whereas 15.5% of the quarters showed a subclinical mastitis (SCC ≥ 200,000 cells/mL). We could assign 1,288 isolates to 104 different bacterial species including 23 predominant species. Non-aureus staphylococci and mammaliicocci (NASM) were most prevalent (14 different species; 73.5% quarters). Staphylococcus xylosus and Mammaliicoccus sciuri accounted for 74.7% of all NASM isolates. To describe the intramammary resistome, 350 isolates of the predominant species were selected and subjected to short-read whole genome sequencing (WGS) and phenotypic antibiotic resistance profiling. While complete genomes of eight type strains were available, the remaining 15 were de novo assembled with long reads as a resource for the community. The 23 complete genomes served for reference-based assembly of the Illumina WGS data. Both chromosomes and mobile genetic elements were examined for antibiotic resistance genes (ARGs) using in-house and online software tools. ARGs were then correlated with phenotypic antibiotic resistance data from minimum inhibitory concentration (MIC). Phenotypic and genomic antimicrobial resistance was isolate-specific. Resistance to clindamycin and oxacillin was most frequently observed (65 and 30%) in Staphylococcus xylosus but could not be linked to chromosomal or plasmid-borne ARGs. However, in several cases, the observed antimicrobial resistance could be explained by the presence of mobile genetic elements like tetK carried on small plasmids. This represents a possible mechanism of transfer between non-pathogenic bacteria and pathogens of the mammary gland within and between herds. The-to our knowledge-most extensive bacteriome reported and the first attempt to link it with the resistome promise to profoundly affect veterinary bacteriology in the future and are highly relevant in a One Health context, in particular for mastitis, the treatment of which still heavily relies on antibiotics.
Application of quantitative real-time PCR to detect Mink Circovirus in minks, foxes and raccoon dogs in northern China
Authors: Liu Yingyu , Sheng Chenyan , Zhou Yu , Li Jianming , Gong Qinglong , Shi Kun , Liu Fei , Xu Lihui , Cui Zhenzhen , Leng Xue , Du Rui
Published: July 2023

Mink circovirus disease caused by Mink Circovirus (MiCV) is a serious infectious disease of mink that has become prevalent in recent years in China, severely affecting the reproductive performance of mink and causing significant economic losses to farms. To date, there have been few studies on MiCV, its pathogenic mechanism is not clear, and there is no effective vaccine or drug to prevent and control the disease. Therefore, it is necessary to establish a rapid and reliable molecular diagnostic method, which would aid future studies of this novel virus. In our study, we developed a sensitive and specific TaqMan-based quantitative real-time PCR assay targeting the MiCV Cap gene. The assay showed no cross-reaction with other tested animal viruses. The assay is highly sensitive, with a detection limit of as low as 10 plasmid DNA copies and 2.38 × 10−2 pg of viral DNA. The intra and inter--assay coefficients of variation were both low. The positive detection rate of MiCV in clinical samples from minks, foxes, and raccoon dogs were 58.8% (133/226), 50.7% (72/142), and 42.2% (54/128), respectively, giving a total positive detection rate of 52.2% (259/496). Higher contamination levels were observed in samples from the environment in direct or indirect contact with animals, with a total positive detection rate of 75.1% (220/293). These epidemiological results showed that minks, foxes, and raccoon dogs had high infection rates of MiCV. This was also the first study to detect MiCV on the ground and equipment of fur-bearing animal farms. Our assay is highly sensitive and specific for the diagnosis and quantification of MiCV, and should provide a reliable real-time tool for epidemiological and pathogenetic study of MiCV infection.
The role of gastric microecological dysbiosis in gastric carcinogenesis
Authors: Huang Hui , Zhong Wei , Wang Xiaojiao , Yang Ying , Wu Tianmu , Chen Runyang , Liu Yanling , He Feng , Li Jun
Published: July 2023

Gastric cancer (GC) is the leading cause of cancer-related death worldwide, and reducing its mortality has become an urgent public health issue. Gastric microecological dysbiosis (including bacteria, fungi, viruses, acid suppressants, antibiotics, and surgery) can lead to gastric immune dysfunction or result in a decrease in dominant bacteria and an increase in the number and virulence of pathogenic microorganisms, which in turn promotes development of GC. This review analyzes the relationship between gastric microecological dysbiosis and GC, elucidates dynamic alterations of the microbiota in Correa’s cascade, and identifies certain specific microorganisms as potential biomarkers of GC to aid in early screening and diagnosis. In addition, this paper presents the potential of gastric microbiota transplantation as a therapeutic target for gastric cancer, providing a new direction for future research in this field.
The decoupling between hemodynamic parameters and neural activity implies a complex origin of spontaneous brain oscillations
Authors: Li Ming , He Lihua , Zhang Zhuo , Li Zhen , Zhu Xuan , Jiao Chong , Hu Dewen
Published: July 2023

Introduction

Spontaneous low-frequency oscillations play a key role in brain activity. However, the underlying mechanism and origin of low-frequency oscillations remain under debate.

Methods

Optical imaging and an electrophysiological recording system were combined to investigate spontaneous oscillations in the hemodynamic parameters and neuronal activity of awake and anesthetized mice after Nω-nitro-L-arginine methyl ester (L-NAME) administration.

Results

The spectrum of local field potential (LFP) signals was significantly changed by L-NAME, which was further corroborated by the increase in energy and spatial synchronization. The important finding was that L-NAME triggered regular oscillations in both LFP signals and hemodynamic signals. Notably, the frequency peak of hemodynamic signals can be different from that of LFP oscillations in awake mice.

Discussion

A model of the neurovascular system was proposed to interpret this mismatch of peak frequencies, supporting the view that spontaneous low-frequency oscillations arise from multiple sources.
Clinical heterogeneity of neuro-inflammatory PET profiles in early Alzheimer’s disease
Authors: Gouilly Dominique , Salabert Anne-Sophie , Bertrand Elsa , Goubeaud Marie , Catala Hélène , Germain Johanne , Ainaoui Nadéra , Rafiq Marie , Benaiteau Marie , Carlier Jasmine , Nogueira Leonor , Planton Mélanie , Hitzel Anne , Méligne Déborah , Sarton Benjamine , Silva Stein , Lemesle Béatrice , Payoux Pierre , Thalamas Claire , Péran Patrice , Pariente Jérémie
Published: July 2023

The relationship between neuroinflammation and cognition remains uncertain in early Alzheimer’s disease (AD). We performed a cross-sectional study to assess how neuroinflammation is related to cognition using TSPO PET imaging and a multi-domain neuropsychological assessment. A standard uptake value ratio (SUVR) analysis was performed to measure [18F]-DPA-714 binding using the cerebellar cortex or the whole brain as a (pseudo)reference region. Among 29 patients with early AD, the pattern of neuroinflammation was heterogeneous and exhibited no correlation with cognition at voxel-wise, regional or whole-brain level. The distribution of the SUVR values was independent of sex, APOE phenotype, early and late onset of symptoms and the presence of cerebral amyloid angiopathy. However, we were able to demonstrate a complex dissociation as some patients with similar PET pattern had opposed neuropsychological profiles while other patients with opposite PET profiles had similar neuropsychological presentation. Further studies are needed to explore how this heterogeneity impacts disease progression.
Validation of computational models to characterize cumulative intake curves from video-coded meals
Authors: Pearce Alaina L. , Brick Timothy R.
Published: July 2023

Introduction

Observational coding of eating behaviors (e.g., bites, eating rate) captures behavioral characteristics but is limited in its ability to capture dynamic patterns (e.g., temporal changes) across a meal. While the Universal Eating Monitor captures dynamic patterns of eating through cumulative intake curves, it is not commonly used in children due to strict behavioral protocols. Therefore, the objective of this study was to test the ability of computational models to characterize cumulative intake curves from video-coded meals without the use of continuous meal weight measurement.

Methods

Cumulative intake curves were estimated using Kisslieff’s Quadratic model and Thomas’s logistic ordinary differential equation (LODE) model. To test if cumulative intake curves could be characterized from video-coded meals, three different types of data were simulated: (1) Constant Bite: simplified cumulative intake data; (2) Variable Bite: continuously measured meal weight data; and (3) Bite Measurement Error: video-coded meals that require the use of average bite size rather than measured bite size.

Results

Performance did not differ by condition, which was assessed by examining model parameter recovery, goodness of fit, and prediction error. Therefore, the additional error incurred by using average bite size as one would with video-coded meals did not impact the ability to accurately estimate cumulative intake curves. While the Quadratic and LODE models were comparable in their ability to characterize cumulative intake curves, the LODE model parameters were more distinct than the Quadradic model. Greater distinctness suggests the LODE model may be more sensitive to individual differences in cumulative intake curves.

Discussion

Characterizing cumulative intake curves from video-coded meals expands our ability to capture dynamic patterns of eating behaviors in populations that are less amenable to strict protocols such as children and individuals with disordered eating. This will improve our ability to identify patterns of eating behavior associated with overconsumption and provide new opportunities for treatment.
Recent advances in our understanding of NEC diagnosis, prognosis and surgical approach
Authors: Bethell George S. , Hall Nigel J.
Published: July 2023

Necrotising enterocolitis (NEC) remains a devasting condition that has seen limited improvement in outcomes in recent years. The incidence of the disease is increasing as more extremely premature infants survive. NEC is responsible for 1 in 10 neonatal deaths and up to 61% of survivors have significant neurodevelopmental delay. The aim of this review is to highlight recent advances in diagnosis, prognosis and surgical approach in this condition. Many recent studies have reported novel methods of diagnosis of NEC with the aim of earlier and more accurate identification. These include imaging and machine learning techniques. Prognostication of NEC is particularly important to allow earlier escalation of therapy. Around 25% of infants with NEC will require surgery and recent data has shown that time from disease onset to surgery is greater in infants whose indication for surgery is failed medical management, rather than pneumoperitoneum. This indication was also associated with worse outcomes compared to pneumoperitoneum. Ongoing research has highlighted several new methods of disease prognostication which includes differentiating surgical from medical NEC. Finally, recent randomised controlled trials in surgical technique are discussed along with the implications of these for practice. Further, high quality research utilising multi-centre collaborations and high fidelity data from electronic patient records is needed to address the issues discussed and ultimately improve outcomes in NEC.
Efficacy of metformin in prevention of paclitaxel-induced peripheral neuropathy in breast cancer patients: a randomized controlled trial
Authors: Bakry Hala M. , Mansour Noha O. , ElKhodary Tawfik R. , Soliman Moetaza M.
Published: July 2023

Background: Paclitaxel-induced peripheral neuropathy (PN) is a serious clinical problem with no approved drug for prevention. This study aimed to examine the neuroprotective effect of metformin against paclitaxel-induced PN in breast cancer patients.

Methods: Patients with confirmed breast cancer diagnosis who were planned to receive paclitaxel were randomized to receive either metformin or placebo. Both groups received the standard chemotherapy protocol for breast cancer. Patients started metformin/placebo 1 week before paclitaxel initiation and continued study interventions thereafter for nine consecutive weeks. The primary outcome was the incidence of development of grade two or more paclitaxel-induced sensory PN. The PN was graded according to the National Cancer Institute Common Terminology Criteria for Adverse Events (NCI-CTCAE). Patients’ quality of life (QoL) was assessed by the Functional Assessment of Cancer Therapy/Gynecologic Oncology Group-Neurotoxicity (FACTGOG-Ntx) subscale. Pain severity was measured by the Brief Pain Inventory Short Form (BPI-SF). Serum levels of nerve growth factor (NGF) and neurotensin (NT) were measured at baseline and at the end paclitaxel treatment.

Results: A total of 73 patients (36 in the metformin arm and 37 in the control arm) were evaluated. The cumulative incidence of development of grade two or more PN was significantly lower in the metformin arm (14 (38.9%) than the control arm (28 (75.7%); p = 0.001). At the end of paclitaxel treatment, patients’ QoL was significantly better in the metformin arm [median (IQR) FACTGOG-Ntx subscale of (24.0 (20.5–26.5)] compared to the control arm (21.0 (18.0–24.0); p = 0.003). The metformin arm showed lower “average” and “worst” pain scores than those detected in the control arm. At the end of the paclitaxel treatment, there was a significant difference in the median serum NGF levels between the two arms, favoring metformin (p < 0.05), while NT serum levels were deemed comparable between the two study arms (p = 0.09).

Conclusion: The use of metformin in breast cancer patients offered a marked protection against paclitaxel-induced PN, which translated to better patient QoL.

Clinical Trial Registration: https://classic.clinicaltrials.gov/ct2/show/NCT05351021, identifier NCT05351021.
Cell-based medicinal products approved in the European Union: current evidence and perspectives
Authors: Bellino Stefania , La Salvia Anna , Cometa Maria Francesca , Botta Rosanna
Published: July 2023

Advanced Therapy Medicinal Products (ATMPs) are innovative clinical treatments exploiting the pharmacological, immunological, or metabolic properties of cells and/or gene(s) with the aim to restore, correct, or modify a biological function in the recipient. ATMPs are heterogeneous medicinal products, developed mainly as individualized and patient-specific treatments, and represent new opportunities for diseases characterized by a high-unmet medical need, including rare, genetic and neurodegenerative disorders, haematological malignancies, cancer, autoimmune, inflammatory and orthopaedic conditions. Into the European Union (EU) market, the first ATMP has been launched in 2009 and, to date, a total of 24 ATMPs have been approved. This review aims at reporting on current evidence of cell-based therapies authorized in the EU, including Somatic Cell Therapies, Tissue Engineering Products, and Cell-based Gene Therapy Products as Chimeric Antigen Receptor (CAR) T-cells, focusing on the evaluation of efficacy and safety in clinical trials and real-world settings. Despite cell-based therapy representing a substantial promise for patients with very limited treatment options, some limitations for its widespread use in the clinical setting remain, including restricted indications, highly complex manufacturing processes, elevated production costs, the lability of cellular products over time, and the potential safety concerns related to the intrinsic characteristics of living cells, including the risk of severe or life-threatening toxicities, such as CAR-T induced neurotoxicity and cytokine release syndrome (CRS). Although encouraging findings support the clinical use of ATMPs, additional data, comparative studies with a long-term follow-up, and wider real-world evidences are needed to provide further insights into their efficacy and safety profiles.
How about running on Mars? Influence of sensorimotor coherence on running and spatial perception in simulated reduced gravity
Authors: Keime Marie , Chomienne Loïc , Goulon Cédric , Sainton Patrick , Lapole Thomas , Casanova Rémy , Bossard Martin , Nicol Caroline , Martha Cécile , Bolmont Benoit , Hays Arnaud , Vercruyssen Fabrice , Chavet Pascale , Bringoux Lionel
Published: July 2023

Motor control, including locomotion, strongly depends on the gravitational field. Recent developments such as lower-body positive pressure treadmills (LBPPT) have enabled studies on Earth about the effects of reduced body weight (BW) on walking and running, up to 60% BW. The present experiment was set up to further investigate adaptations to a more naturalistic simulated hypogravity, mimicking a Martian environment with additional visual information during running sessions on LBPPT. Twenty-nine participants performed three sessions of four successive five-min runs at preferred speed, alternating Earth- or simulated Mars-like gravity (100% vs. 38% BW). They were displayed visual scenes using a virtual reality headset to assess the effects of coherent visual flow while running. Running performance was characterized by normal ground reaction force and pelvic accelerations. The perceived upright and vection (visually-induced self-motion sensation)in dynamic visual environments were also investigated at the end of the different sessions. We found that BW reduction induced biomechanical adaptations independently of the visual context. Active peak force and stance time decreased, while flight time increased. Strong inter-individual differences in braking and push-off times appeared at 38% BW, which were not systematically observed in our previous studies at 80% and 60% BW. Additionally, the importance given to dynamic visual cues in the perceived upright diminished at 38% BW, suggesting an increased reliance on the egocentric body axis as a reference for verticality when the visual context is fully coherent with the previous locomotor activity. Also, while vection was found to decrease in case of a coherent visuomotor coupling at 100% BW (i.e., post-exposure influence), it remained unaffected by the visual context at 38% BW. Overall, our findings suggested that locomotor and perceptual adaptations were not similarly impacted, depending on the -simulated- gravity condition and visual context.
From urine to food and oxygen: effects of high and low NH4+:NO3- ratio on lettuce cultivated in a gas-tight hydroponic facility
Authors: Schiefloe Mona , Jakobsen Øyvind Mejdell , Pannico Antonio , Quadri Claudia , Jost Ann-Iren Kittang
Published: July 2023

In situ production of food, water and oxygen is essential for long-duration human space missions. Higher plants represent a key element in Bioregenerative Life Support Systems (BLSS), where crop cultivation can be based on water and nutrients recovered from waste and wastewater. Human urine exemplifies an important waste stream with potential to provide crops with nitrogen (N) and other nutrients. Dynamic waste composition and treatment processes may result in mineralized fractions with varying ammonium (NH4+) to nitrate (NO3-) ratios. In this study, lettuce was cultivated in the unique ESA MELiSSA Plant Characterization Unit, an advanced, gas-tight hydroponic research facility offering controlled environment and continuous monitoring of atmospheric gas composition. To evaluate biological and system effects of nutrient solution NH4+:NO3- ratio, two crop tests were run with different NH4+ to total N ratio (NH4+:N) and elevated concentrations of Na+ and Cl- in line with a urine recycling scenario. Plants cultivated at 0.5 mol·mol-1 NH4+:N (HiNH4+) achieved 50% lower shoot biomass compared to those cultivated at 0.1 mol·mol-1 NH4+:N (LoNH4+), accompanied by higher shoot dry weight content and lower harvest index. Analyses of projected leaf area over time indicated that the reduced biomass observed at harvest could be attributed to a lower specific growth rate during the close-to-exponential growth phase. The HiNH4+ crop produced 40% less O2 over the full cultivation period. However, normalization of the results indicated a marginal increase in O2 production per time and per projected leaf area for the HiNH4+ crop during the exponential growth phase, in line with a higher shoot chlorophyll content. Mineral analysis demonstrated that the biomass content of NH4+ and NO3- varied in line with the nutrient solution composition. The ratio of consumed NH4+ to consumed N was higher than the NH4+:N ratio of the nutrient solution for both crop tests, resulting in decreasing NH4+:N ratios in the nutrient solution over time. The results provide enhanced insight for design of waste processes and crop cultivation to optimize overall BLSS efficiency and hold valuable potential for improved resource utilization also in terrestrial food production systems.
Linked candidate genes of different functions for white mold resistance in common bean (Phaseolus vulgaris L) are identified by multiple QTL mapping approaches
Authors: Oladzad Atena , Roy Jayanta , Mamidi Sujan , Miklas Phillip N. , Lee Rian , Clevenger Josh , Myers Zachary , Korani Walid , McClean Phillip E.
Published: July 2023

White mold (WM) is a major disease in common bean (Phaseolus vulgaris L.), and its complex quantitative genetic control limits the development of WM resistant cultivars. WM2.2, one of the nine meta-QTL with a major effect on WM tolerance, explains up to 35% of the phenotypic variation and was previously mapped to a large genomic interval on Pv02. Our objective was to narrow the interval of this QTL using combined approach of classic QTL mapping and QTL-based bulk segregant analysis (BSA), and confirming those results with Khufu de novo QTL-seq. The phenotypic and genotypic data from two RIL populations, ‘Raven’/I9365-31 (R31) and ‘AN–37’/PS02–029C–20 (Z0726-9), were used to select resistant and susceptible lines to generate subpopulations for bulk DNA sequencing. The QTL physical interval was determined by considering overlapping interval of the identified QTL or peak region in both populations by three independent QTL mapping analyses. Our findings revealed that meta-QTL WM2.2 consists of three regions, WM2.2a (4.27-5.76 Mb; euchromatic), WM 2.2b (12.19 to 17.61 Mb; heterochromatic), and WM2.2c (23.01-25.74 Mb; heterochromatic) found in both populations. Gene models encoding for gibberellin 2-oxidase 8, pentatricopeptide repeat, and heat-shock proteins are the likely candidate genes associated with WM2.2a resistance. A TIR-NBS-LRR class of disease resistance protein (Phvul.002G09200) and LRR domain containing family proteins are potential candidate genes associated with WM2.2b resistance. Nine gene models encoding disease resistance protein [pathogenesis-related thaumatin superfamily protein and disease resistance-responsive (dirigent-like protein) family protein etc] found within the WM2.2c QTL interval are putative candidate genes. WM2.2a region is most likely associated with avoidance mechanisms while WM2.2b and WM2.2c regions trigger physiological resistance based on putative candidate genes.
Capturing dynamics in nursing: a diary study of nurses’ job characteristics and ability and willingness to continue working
Authors: Vermeulen Renée Cornelia Josephina Maria , van Leeuwen Evelien Hanna
Published: July 2023

Objectives

This study aimed to gain insight into (1) the dynamics of job characteristics (demands and resources) of nurses and (2) how job characteristics relate to nurses’ ability and willingness to continue working (understood as employability). Job characteristics are profession-specific and vary over time, but studies often overlook these dynamics. Moreover, job characteristics relate to nurses’ employability, which is under pressure due to a rapidly changing work environment. It is necessary to gain insight into the dynamic job characteristics of nurses to develop targeted workplace interventions that help nurses remain employable.

Methods

This study adopted a mixed methods diary approach, with a strong emphasis on qualitative analysis. 46 Nurses from two hospitals in a large Dutch city completed a structured diary at six points over 3 weeks, resulting in 225 diary entries in total. The nurses used a custom-made application on their mobile devices to describe in their own words what they experienced as demanding and resourceful throughout the shifts and how they experienced their employability. Prior to the diaries, nurses completed an intake survey.

Results

A within-person analysis highlighted the day-to-day dynamics in the nursing profession. The job characteristics a nurse mentioned in the first diary entry often were completely different from the job characteristics the same nurse mentioned in the other diary entries. This analysis also showed variety within nurses’ employability, demonstrating that perceptions of employability vary over time. A between-person analysis highlighted links between job characteristics and nurses’ employability: social interactions strengthen a nurse’s employability, a strict task approach threatens it, and aspects such as a strong drive to care, professional development, and autonomy (clustered as aspects that enable to “act professionally”) create opportunities to enhance employability.

Conclusion

Insights from this study show that job characteristics typical to the nursing profession can be linked to nurses’ perceptions of employability. Also, it stems from this research that not only job characteristics but also employability are dynamic in the short run. Understanding and enhancing employability in a nursing context requires capturing these dynamics, for instance by collecting data at several points in time or by using mixed-method studies to understand employability scores within their context.
Distress symptoms and alcohol consumption: anxiety differentially mediates drinking across gender
Authors: Torres Oscar V. , Estep Justin C. , Gwin Mary , Aramovich Nicholas P. , Thomas Giovanni , Villalta Lan
Published: July 2023

Introduction

The consumption of alcohol remains a significant health concern and represents a prevalent form of substance use worldwide. Previous research has identified sex differences in the consumption of alcohol. This study explores the relationship between drinking and the presence of distress symptoms across gender. Based on previous research, it was hypothesized that presence of distress symptoms, defined as increases in anxiety and depression, would be prominent features associated with alcohol consumption among women compared to men.

Methods

A sample of undergraduate students (N = 448) participated in an online-based questionnaire (71% female; M age = 22.1; 42.9% Hispanic/Latino). The questionnaire contained assessments related to demographic information and alcohol consumption over the past 30 days. Anxiety and depression symptoms were assessed using the Hospital Anxiety and Depression Scale.

Results

Gender differences were observed with men consuming more alcoholic drinks than women. However, women who consumed alcohol reported having more distress symptoms relative to their male counterparts. A logistic regression revealed that this gender difference was moderated by anxiety, such that greater anxiety scores associates with whether women consumed alcohol. However, an ordinary least squares regression revealed that for men, anxiety scores significantly related to the amount of drinks consumed. Gender differences were not detected in relation to alcohol consumption and depression.

Conclusion

Our findings contribute to the literature by indicating that the mere presence of distress symptoms reveals distinctive gender-specific differences in relation to alcohol consumption in a non-clinical population. Identifying the distinct associations linked with alcohol use for men and women can aid in reducing drinking disparities among young adults.
Effects of emotion words activation and satiation on facial expression perception: evidence from behavioral and ERP investigations
Authors: Xu Qiang , Wang Weihan , Yang Yaping , Li Wanyue
Published: July 2023

Objective

The present study investigated the impact of emotion concepts obtained from external environmental experiences on the perception of facial expressions by manipulating the activation and satiation of emotion words, which was based on the argument between basic emotion theory and constructed emotion theory.

Methods

Experiment 1 explored the effects of emotion activation on happy, disgusted, emotion-label words and emotion-laden words in a facial expression judgment task through behavioral experimentation. Experiment 2 explored the effect of semantic satiation on emotion-label words and emotion-laden words using the event-related potential technique.

Results

Experiment 1 found that facial expression perception was influenced by both types of emotion words and showed a significant emotional consistency effect. Experiment 2 found that N170 exhibited a more negative amplitude in the consistent condition compared to the inconsistent condition in the right hemisphere. More importantly, in the later stage of facial expression processing, emotion-label words and emotion-laden words both obstructed the perception of disgusted facial expressions and elicited more negative N400 amplitude in the emotion consistency condition, showing a reversed N400 effect.

Conclusion

These results suggested that emotion concepts in the form of language influenced the perception of facial expressions, but there were differences between happy and disgusted faces. Disgusted faces were more dependent on emotion concept information and showed different performances in semantic activation and satiation conditions.
Efficacy and safety of intermittent theta burst stimulation versus high-frequency repetitive transcranial magnetic stimulation for patients with treatment-resistant depression: a systematic review
Authors: Lan Xian-Jun , Yang Xin-Hu , Qin Zhen-Juan , Cai Dong-Bin , Liu Qi-Man , Mai Jian-Xin , Deng Can-jin , Huang Xing-Bing , Zheng Wei
Published: July 2023

Objective

Intermittent theta-burst stimulation (iTBS), which is a form of repetitive transcranial magnetic stimulation (rTMS), can produce 600 pulses to the left dorsolateral prefrontal cortex (DLPFC) in a stimulation time of just over 3 min. The objective of this systematic review was to compare the safety and efficacy of iTBS and high-frequency (≥ 5 Hz) rTMS (HF-rTMS) for patients with treatment-resistant depression (TRD).

Methods

Randomized controlled trials (RCTs) comparing the efficacy and safety of iTBS and HF-rTMS were identified by searching English and Chinese databases. The primary outcomes were study-defined response and remission.

Results

Two RCTs (n = 474) investigating the efficacy and safety of adjunctive iTBS (n = 239) versus HF-rTMS (n = 235) for adult patients with TRD met the inclusion criteria. Among the two included studies (Jadad score = 5), all were classified as high quality. No group differences were found regarding the overall rates of response (iTBS group: 48.0% versus HF-rTMS group: 45.5%) and remission (iTBS group: 30.0% versus HF-rTMS group: 25.2%; all Ps > 0.05). The rates of discontinuation and adverse events such as headache were similar between the two groups (all Ps > 0.05).

Conclusion

The antidepressant effects and safety of iTBS and HF-rTMS appeared to be similar for patients with TRD, although additional RCTs with rigorous methodology are needed.
Effectiveness of personalized smoking cessation intervention based on ecological momentary assessment for smokers who prefer unaided quitting: protocol for a randomized controlled trial
Authors: Zhang Min Jin , He Wan Jia Aaron , Luk Tzu Tsun , Wang Man Ping , Chan Sophia Siu Chee , Cheung Yee Tak Derek
Published: July 2023

Introduction

Ecological momentary assessment (EMA)-based smoking cessation intervention may help personalize intervention for smokers who prefer to quit smoking unaided. This study aims to evaluate the effectiveness of EMA-based phone counseling and instant messaging for smoking cessation.

Methods/design

This is a two-arm, accessor-blinded, simple individual randomized controlled trial (allocation ratio 1:1). Participants will be recruited from community sites and online platforms in Hong Kong. Interventions will be delivered via a phone call and instant messaging. Current adult smokers who (1) self-report no intention to use smoking cessation services and medication in the coming month and (2) have not used smoking cessation services or nicotine replacement therapy in the past 7 days will be recruited. Recruited participants will be randomized to intervention or control groups via an online randomizer. All participants will be required to complete EMAs (five times per day for 7 consecutive days). The intervention group (n= 220) will receive a nurse-led brief phone counseling immediately after the 1-week EMAs and 10-week EMA-based advice via instant messaging applications (e.g., WhatsApp, WeChat). The 10-week EMA-based advice covers a summary of the 1-week EMAs, and tailored cessation support focused on personalized smoking triggers. The control group (n= 220) will not receive any intervention during the same period. The primary outcomes are participants' progression toward smoking cessation assessed by the Incremental Behavior Change toward Smoking Cessation (IBC-S) and biochemically validated abstinence at the 3-month follow-up. Secondary outcomes include self-reported and biochemically validated tobacco abstinence at the 6-month follow-up.

Discussion

The findings will provide evidence that the EMA-based tailored smoking cessation intervention can be adapted as a new health promotion strategy for current smokers who are unwilling to use smoking cessation aids.

Clinical trial registration

https://classic.clinicaltrials.gov/ct2/show/NCT05212220, identifier: NCT05212220.
Investigation of the relationship of general and digital health literacy with various health-related outcomes
Authors: Bíró Éva , Vincze Ferenc , Nagy-Pénzes Gabriella , Ádány Róza
Published: July 2023

Background

Despite the growing number of health literacy surveys, we know little about the combined effect of the different dimensions of health literacy on various health-related outcomes.

Objective

Thus, our study aimed to examine the impacts of general and digital health literacy on health behaviour, confidence in vaccination, self-perceived health, and health care utilization.

Methods

Our research was part of the Health Literacy Population Survey 2019–2021, which was an international, multicentre, cross-sectional study. The data were collected via computer-assisted telephone interview in December 2020 in Hungary. Multiple multinomial logistic and multivariate linear regression models were used to analyse the separately effects of general and digital health literacy on the studied outcomes. Moreover, the combined effect of general and digital health literacy was also analysed via sensitivity analyses. In the last step, the interactions between general and digital health literacy were examined using the Johnson-Neyman procedure.

Results

The results did not reveal any associations between health literacy and health behaviour. Health care use was only affected by digital health literacy; however, this effect was inconsistent. Both dimensions of health literacy were positively associated with self-perceived health and vaccination confidence.

Conclusion

Our results suggest that increasing health literacy could promote health and vaccination confidence, while the potential effect of higher digital health literacy on more conscious use of the health care system should be investigated further.
Occurrence of heavy precipitation influenced by solar wind high-speed streams through vertical atmospheric coupling
Authors: Prikryl Paul , Rušin Vojto
Published: July 2023

A tendency of heavy rainfall-induced floods in Canada to follow arrivals of solar wind high-speed streams (HSSs) from coronal holes is observed. Precipitation events during the winter, including extreme freezing rain events in the province of New Brunswick, also tend to occur following HSSs. More direct evidence is provided using the satellite-based gridded precipitation dataset Integrated Multi-satellitE Retrievals for GPM (IMERG) in the superposed epoch analysis of high-rate precipitation. The results show an increase in the high-rate daily precipitation occurrence over Canada following arrivals of major HSSs. This is consistent with previously published results for other mid-latitude geographic regions. The ERA5 meteorological reanalysis is used to evaluate the slantwise convective available potential energy (SCAPE) that is of importance in the development of storms. The role of the solar wind-magnetosphere-ionosphere-atmosphere coupling, mediated by globally propagating aurorally excited atmospheric gravity waves releasing the conditional symmetric instability in the troposphere leading to convection and precipitation, is proposed.
Case report and review: Angiosarcoma with thrombocytopenia after total hip arthroplasty
Authors: Skants Noora , Rönty Mikko , Komulainen Olli , Keski-Keturi Miikka , Huotari Kaisa , Alander-Pekkarinen Maria , Sihvo Marjut , Laitinen Minna , Linko Rita
Published: July 2023

Total hip arthroplasty (THA) is a common treatment for osteoarthritis and is also performed for other conditions, such as secondary arthritis due to developmental dysplasia of the hip. Various THA types may be complicated by osteolysis and an inflammatory pseudotumor due to an adverse reaction to metal debris. Rarely, THA has been associated with malignant tumors, but their causality remains unclear. In this case report, we describe a female patient with developmental dysplasia of the hip. She had undergone left metal-on-polyethylene THA, acetabular revision of the THA, and left total knee arthroplasty. In addition, she had a history of dyslipidemia and telangiectasia of the eyes, anemia, hiatal hernia, and pleuritis. A THA-associated mass (suspected to be a pseudotumor) had been detected during a previous hospital admission due to pleuritis. She was hospitalized due to swelling in her left lower limb, fatigue, and bruises. A clinical examination revealed anemia, thrombocytopenia, and growth of the suspected pseudotumor. Within 6 weeks, she presented with bleeding of the oral mucosa, hemoptysis, melena, severe thrombocytopenia that did not respond to treatment, elevated D-dimer and C-reactive protein levels, severe pain, increased osteolysis, and fractures around the THA. Infection or malignancy was suspected, but two trocar biopsies suggested an inflammatory pseudotumor. Since her anemia and thrombocytopenia were considered to have been caused by an inflammatory process within the suspected pseudotumor, her suspected pseudotumor and all THA components were surgically removed. However, she developed severe alveolar hemorrhaging and hypoxia and died 2 weeks after her surgery. Histopathological analysis of her surgical and autopsy samples revealed highly malignant angiosarcoma. Although individual cases of malignancies associated with THA have been reported, the literature lacks a clear association between THA and increased cancer risk. Most pseudotumors are non-malignant. The patient's case presented in this report exemplifies the challenges to the differential diagnosis of a THA-associated pseudotumor and rare angiosarcoma. Atypically rapid tumor growth, severe osteolysis, and deterioration in the general wellbeing suggest a malignant disease.
A comparison of men and women undergoing septoplasty—the Swedish national septoplasty register
Authors: Pedersen Lars , Holmberg Kenneth , Ahlström Emanuelsson Cecilia , Schiöler Linus , Steinsvåg Sverre , Hellgren Johan
Published: July 2023

Objective

Men represent more than two-thirds of septoplasty patients in many studies, but differences between men and women in terms of patient selection or outcome are seldom reported. This study aims to investigate whether women undergoing septoplasty differ from men in critical variables before and after surgery, in a large national sample of septoplasties.

Design

Cross-sectional register study.

Participants

The study includes 2,532 patients from the National Swedish Septoplasty Register undergoing septoplasty with or without additional turbinoplasty on the indication of nasal obstruction in 2014–2019. Patients in the register have not been preselected.

Main outcome measures

Preoperative variables and postoperative outcome were compared between men and women.

Results

Men accounted for 1,829 (72%) of the patients. There was no significant difference between men and women in severity of self-reported nasal obstruction or type of surgery performed (septoplasty with or without turbinoplasty). Mean postoperative nasal obstruction 12 months after surgery and overall satisfaction with the result were similar. Women, however, reported more complications 12 months postoperatively, while men reported more problems with snoring and obstructive sleep apnea preoperatively.

Conclusion

In this large national patient cohort undergoing septoplasty, we found no differences in preoperative nasal obstruction or postoperative patient-rated outcome in men and women undergoing septoplasty, despite the fact that 72% of the patients were men. It thus remains unclear why women are under-represented in septoplasty surgery in this and many other cohorts.
Special Issue “Algorithms for Feature Selection”
Authors: Khan Muhammad Adnan
Published: July 2023

This Special Issue of the open access journal Algorithms is dedicated to showcasing cutting-edge research in algorithms for feature selection [...]
Rendezvous and Proximity Operations in Cislunar Space Using Linearized Dynamics for Estimation
Authors: Zuehlke David , Tiwari Madhur , Jebari Khalid , Kidambi Krishna Bhavithavya
Published: July 2023

As interest in Moon exploration grows, and efforts to establish an orbiting outpost intensify, accurate modeling of spacecraft dynamics in cislunar space is becoming increasingly important. Contrary to satellites in Low Earth Orbit (LEO), where it takes around 5 ms to communicate back and forth with a ground station, it can take up to 2.4 s to communicate with satellites near the Moon. This delay in communication can make the difference between a successful docking and a catastrophic collision for a remotely controlled satellite. Moreover, due to the unstable nature of trajectories in cislunar space, it is necessary to design spacecraft that can autonomously make frequent maneuvers to stay on track with a reference orbit. The communication delay and unstable trajectories are exactly why autonomous navigation is critical for proximity operations and rendezvous and docking missions in cislunar space. Because spacecraft computational hardware is limited, reducing the computational complexity of navigational algorithms is both desirable and often necessary. By the introduction of a linear system approach to the deputy spacecraft motion, this research avoids the computational burden of integrating the deputy relative equations of motion. In this research, the relative CR3BP equations of motion are derived and linearized using a matrix exponential approximation. This research continues the development of the matrix exponential linearized relative circular restricted three-body problem (CR3BP) equations by applying the dynamics model to estimation and control applications. A simulation is performed to compare state estimation results obtained from using the linearized equations of motion utilizing a Kalman filter and for state estimation utilizing an unscented Kalman filter with the full nonlinear equations of motion. The linearized exponential model is shown to be sufficient for state estimation in the presence of noisy measurements for an example scenario. Additionally, a linear quadratic regulator (LQR) controller was added to optimally control a deputy spacecraft to rendezvous with a chief spacecraft in cislunar space. The contribution of this work is twofold: to provide a proof of concept that the matrix exponential solution for the linearized relative CR3BP equations can be used as the dynamics model for state estimation, as well as to simulate an optimal rendezvous maneuver in the presence of measurement noise.
Numerical Study on Buoyancy-Driven Görtler Vortices above Horizontal Heated Flat Plate
Authors: Yang Muqing , Ma Dongli , Zhang Liang
Published: July 2023

The temperature of the solar cells on the upper surface of a solar unmanned aerial vehicle (UAV) wing is much higher than the atmospheric temperature during flight. The temperature difference will induce buoyancy-driven Görtler vortices that may influence the aerodynamic characteristics of the wing. In the present study, a hybrid RANS-LES-based approach was used to simulate the flow above a heated flat plate under different flow velocities (from 0.34 m/s to 0.63 m/s) and temperature differences (from 0 K to 60 K), and the influence of Görtler vortices on the flow was analyzed. The existence of buoyancy-driven Görtler vortices would induce velocity normal to the plate, and a negative velocity normal to the plate at the peak position would enhance the momentum exchange within the boundary layer, accelerate the transition, and increase the friction drag coefficient. The drag coefficient with a 60 K temperature difference is almost three times that with a 0 K temperature difference. With an increase in temperature difference or decrease in flow velocity, the intensity of Görtler vortices would increase. A couple of different buoyancy parameters were studied, and a combined parameter based on both the Reynolds number and Grashoff number was proposed as the index parameter of heated plate flow. The flow above a heated flat plate can be divided into three regions by the buoyancy parameter. When the buoyancy parameter is between 100 and 200, the Görtler vortices are stable, and the flow exhibits significant three-dimensional characteristics.