bluuebunny/crossref_metadata_2025 huggingface dataset:
Cómo somos, qué creemos, cómo vivimos
Authors: Zalpa Ramírez Genaro
Published: March 2022

Este libro es una compilación de artículos y capítulos de libros previamente publicados, los cuales han sido seleccionados personalmente por su autor, Genaro Zalpa, de entre su muy extensa obra académica. En palabras del autor: “Los lectores podrán darse cuenta de que hay artículos de investigación empírica sobre la región purépecha y sobre las costumbres de mi pueblo, sobre las historietas (aunque no sobre las que yo leía en mi infancia), sobre la religión y las creencias, sobre la cultura de las organizaciones y la globalización, sobre la corrupción como problemática cultural de la vida cotidiana de nuestro país, entre otros. Me parece que todos esos artículos, en su diversidad, pueden conformar una unidad compuesta por los cuatro apartados que los aglutinan: Teoría, Cultura, Religión y Metodología. El apartado de teoría, compuesto por ensayos que son el resultado de investigaciones teóricas, está colocado al principio porque lógicamente preceden a los demás artículos, lo cual no quiere decir que temporalmente hayan sido redactados y publicados con anterioridad. Lo coloco al principio porque, desde mi punto de vista, la teoría cumple las funciones de un mapa de la realidad que, sin coincidir con ella (si coincidiera dejaría de ser un mapa para ser, sencillamente, la realidad) nos hace ver fenómenos que no veríamos sin la teoría. Como, por ejemplo, la importancia de las culturas y de las religiones, que conforman dos de los apartados de esta compilación. Finalmente, una curiosidad cultivada no estaría completa sin las herramientas metodológicas para la investigación. No quiere decir, desde luego, que sean las únicas herramientas que he utilizado. Las incluyo aquí porque son, de alguna manera, una contribución original a la relación teoría-metodología”.
RETORIKA INFOGRAFIS PANDEMI CORONA VIRUS MEDIA JURNALISTIK DIGITAL ONLINE
Authors: Handriyotopo Handriyotopo
Published: March 2022

AbstractThe phenomenon of infographics as a visual strategy to attract readers of digital newspapers in order to realize the importance of the protocol issued by WHO and the government of the Republic of Indonesia in an effort to deal with the Covid-19 pandemic, is currently quite prevalent by online media press. The visual form of infographics published by the digital-based press (online) is usually derived to accompany the main article on the front page (headline). The important message of the infographic that is prioritized is not to spread quickly, namely by maintaining social distancing, encouraging work at home, and always maintaining cleanliness and wearing a mask when leaving the house, even then with restrictions. How the form of visual communication design in the form of an infographic is able to provide aesthetic appeal in visual rhetoric to readers who will be the attention of this study. Through a qualitative research method approach to the phenomenon of infographic design from the perspective of text study from the aesthetic value of symbolic visual rhetoric with visual communication design analysis in terms of harmony achievement through its persuasive informative constituent elements. The findings of this study are related to the form of the infographic which is more portrait or vertical dominant. Colors tend to be strong colors red, yellow, blue, and black to indicate pandemic-related color psychology. Visual rhetoric tends to be iconic and header and copy letters are dominant in using sanserif to persuade understanding and reading of information to the reading audience. To remind adherence to health protocols, such as messages from mothers, namely wearing masks, washing hands and maintaining social distancing are the keywords to break this pandemic.Keywords: Covid-19 infographics, aesthetics, visual rhetoric, online press media
MAKNA SIMBOL RELIEF SENGKALAN CANDI SUKUH
Authors: Syafi'i Achmad
Published: March 2022

This research discusses the meaning of the symbol sengkalan relief sukuh temple located in Ngargoyoso, Karanganyar, Central Java. The research focuses on the problem of the interpretation of the meaning of sukuh temple relief symbols in a cultural perspective through Clifford Geertz’s hermeneutic theory, that the symbol is a special sign that is arbritrer or not the same as the one marked and can only be understood in the context interpreted by the culture itself, or is culturally specific. Furthermore, this research reviews the meaning of the presence and visualization of the relief of Sukuh temple which is considered the last relic of Majapahit kingdom. So the purpose of the research is more to explore the presence and meaning of relief sengkalan in Sukuh temple as part of the sign system in Javanese culture. At the same time as an effort to preserve the value of tradition about pralambang in the form of sengkalan that is often used by Javanese people in temple relief, in this context is sukuh temple so that it can be understood by Javanese people now as a way of understanding themselves, life and life as part of the ‘Eastern’ culture. The making of sukuh temple relief sting is possible to uncover events or events at the end of majapahit’s heyday, which may have escaped the historical track record of majapahit kingdom that has been understood. Let the temples speak, so they are not merely banners that lead us to myth and mysticism, but there is a lot of wisdom that they will whisper from the hidden meaning behind the relief of Sukuh temple.Keywords: Meaning, Relief, Sengkalan, Sukuh Temple.
STUDI PUSTAKA TARI SRIMPI MUNCAR GAYA YOGYAKARTA DAN GAYA MANGKUNAGARAN SURAKARTA
Authors: Soemaryatmi Soemaryatmi
Published: March 2022

ABSTRAK Penelitian dengan judul  Studi Pustaka Tari Srimpi Muncar Gaya Yogyakarta dengan Gaya Mangkunegaran Surakarta, merupakan penelitian  membandingkan dua judul tari yang sama guna  menemukan persamaan  untuk ditarik ke dalam konklusi baru. Penelitian pustaka ini bersifat  kualitatif, dengan menggunakan metode  studi pustaka dan pendekatan koreografi.Hasil penelitian menunjukan bahwa, tari Srimpi Muncar yang berkembang di Mangkunagaran Surakarta memiliki persamaan nama dan bentuk dengan tari yang berkembang di Istana Yogyakarta. Jenis tarian yang pada awalnya memiliki nilai sakral dan  dipergelarkan di kalangan terbatas yaitu istana,   seiring perubahan jaman menjadi pertunjukan hiburan dan disajikan dikalangan masyarakat.Tari Srimpi Muncar di Yogyakarta  diciptaan olah Hamengku Buwana ke VI sedang Srimpi Muncar di Mangkunegaran Surakarta disusun kembali oleh Mangkunegara VII. Di dalam sajiannya kedua Tari Srimpi Muncar terdapat perbedaan dan persamaan yang menarik. Tari Srimpi Muncar disusun dengan gerakan tari yang bersumber dari tari bedhaya,  dalam penyajiannya terdapat pengembangan gerak yang spesifik yaitu gerak sojah dan gerak guladrahan, dalam seluruh sajiannya memiliki teknis atau gaya yang berbeda. Adapun persamaannya, struktur sajian, iringan yang digunakan gending Muncar, desain kostum yang digunakan juga menyesuaikan dengan tokoh yang diperankannya yaitu putri cina dan putri jawa. Tema yang diangkat adalah percintaan dengan sumber ceritera mengambil dari Serat Menak yang bernafaskan ke-Islaman.  Kata Kunci: Tari, Muncar, Sojah, Guladrahan, Putri Cina ABSTRACTThe research entitled Literature Review about Srimpi Muncar Dance in Yogyakarta and Mangkunegaran Surakarta Style is a research that compare same dance in two different style. It aimed to find some similarities and then integrated into a new conclusion. It is a qualitatively research which uses literature method and choreography approach.Research result shows that Srimpi Muncar Dance which has developed at Mangkunegaran Surakarta actually has some similarities such as name and format with one else at Yogyakarta Palace. At first, this dance with sacred value performed for special audience. But now, it performed for all audience and come to be entertainment material. Srimpi Muncar dance either in Yogyakarta style or Mangkunegaran style, still in relation with its history. Both of dances have some differences and similarities in performance. Srimpi Muncar dance arranged with specific movements based on bedaya dance. They have specific movement such as sojah and goladraham but different in technique and style. They are equally accompanied by gendhing called Muncar. Costume for these dance allowing characters, Chinese and Javanese princes. Dance theme is romance inspired by Serat Menak with Islamic nuance. Keywords: Muncar Dance, Sojah, Guladrahan, Chinese princess.
TERAPI SENI UNTUK MENGATASI GANGGUAN KECEMASAN PADA LANSIA AKIBAT PANDEMI COVID-19
Authors: Shokiyah Nunuk Nur , Syamsiar Syamsiar
Published: March 2022

The Covid-19 virus is still spreading throughout the world.  In fact, many are worried about being exposed to this virus, especially the elderly.  Anxious feelings due to excessive Covid-19 will lower his immunity.  Over time, this anxiety disorder can get worse and interfere with the sufferer's quality of life, therefore anxiety needs to be managed.  One way to deal with anxiety is through art therapy.Art therapy used in this study is through drawing and fruit creation, where the media used for art therapy is in accordance with the one chosen by the participants.  This study used a qualitative analysis based on: Self Report (Interview and Anxiety Scale using the measurement of anxiety levels using the TMAS (Taylor Manifest Anxiety Scale) instrument compiled and developed by Tylor, given three times, namely (pretest, posttest and follow up).  Ratiing By other, and Observation (Re-checting). The results of this study indicate a change in anxiety levels before and after the intervention.  Evidence obtained from the four participants shows a change in the total value of anxiety.  Thus, art therapy has been shown to reduce anxiety in the elderly due to the Covid-19 pandemicKeywords: Art therapy, Anxiety Disorders and Covid-19
Clinical relevance of an objective flow cytometry approach based on limit of detection and limit of quantification for measurable residual disease assessment in acute myeloid leukemia. A post-hoc analysis of the GIMEMA AML1310 trial
Authors: Buccisano Francesco , Palmieri Raffaele , Piciocchi Alfonso , Arena Valentina , Maurillo Luca , Del Principe Maria-Ilaria , Paterno Giovangiacinto , Irno-Consalvo Maria-Antonietta , Ottone Tiziana , Divona Mariadomenica , Conti Consuelo , Fraboni Daniela , Lavorgna Serena , Arcese William , Voso Maria Teresa , Venditti Adriano
Published: March 2022

Using a multiparametric flow cytometry assay, we assessed the predictive power of a threshold calculated applying the criteria of limit of detection (LOD) and limit of quantitation (LOQ) in adult patients with acute myeloid leukemia. This was a post-hoc analysis of 261 patients enrolled in the GIMEMA AML1310 prospective trial. According to the protocol design, using the predefined measurable residual disease (MRD) threshold of 0.035% bone marrow residual leukemic cells (RLC) calculated on mononuclear cells, 154 (59%) of the 261 patients were negative (MRD <0.035%) and 107 (41%) were positive (MRD ≥0.035%). Using LOD and LOQ, we selected the following categories of patients: (i) LODneg if RLC were below the LOD (74; 28.4%); (ii) LODpos-LOQneg if RLC were between the LOD and LOQ (43; 16.5%); and (iii) LOQpos if RLC were above the LOQ (144; 54.4%). Two-year overall survival of these three categories of patients was 75.4%, 79.8% and 66.4%, respectively (P=0.1197). Given their superimposable outcomes, the LODneg and LODpos-LOQneg categories were combined. Two-year overall survival of LODneg/LODpos-LOQneg patients was 77.0% versus 66.4% of LOQpos individuals (P=0.043). This figure was challenged in univariate analysis (P=0.046, hazard ratio=1.6, 95% confidence interval: 1.01-2.54) which confirmed the independent role of the LOD-LOQ approach in determining overall survival. In the AML1310 protocol, using the threshold of 0.035%, 2-year overall survival of patients with MRD <0.035% and MRD ≥0.035% was 74.5% versus 66.4%, respectively (P=0.3521). In conclusion, the use of the LOD-LOQ method results in more sensitive detection of MRD that, in turn, translates into a more accurate recognition of patients with different outcomes.
The Actualization of Maqamat and Ahwal in Modern Life (Study of the Naqsyabandiyah Babussalam Congregation, Langkat)
Authors: Sabaruddin Bisri  , Sukiman  , Muzakkir
Published: March 2022

The study deals with the actualization of maqamat and ahwal in modern life (study of the naqsyabandiyah Babussalam congregation, Langkat). The purpose of writing this article is to find out the following: 1) Understanding and practicing maqâmat and aḥwâl in the Naqsyabandiyah Babussalam congregation, Langkat; 2) Implementation of maqâmat and aḥwâl on the pilgrims of the Naqsyabandiyah Babussalam congregation, Langkat; and 3) Efforts to implement maqâmat and aḥwâl of the salik and congregations of the Naqsabandiyah Babussalam congregation, Langkat.. It can be concluded that the understanding of maqâmat and aḥwâl in the Naqsyabandiyah Babussalam Langkat congregation, the existence of a maqâmat linkage in the formation of akhlaq al-karîmah means that it can be understood that information on spiritual experience which is also known as inner view as a sign for the sālik when dhikr can also contribute to every sālik as a good Sufi as knowledge and as a driving force for changes in mental attitudes and noble character. So that it can help the sālik to undergo various maqāmat, in order to achieve a good state (aḥwāl). In addition, there is a strong interaction between the mursyid/master teacher and the saints through tawajjuh, recitation, and suluk
Perancangan Arsitektur Jaringan Kampus Menggunakan Metode Network Development Life Cycle
Authors: Adrian Sandy , Cahyana Rinda
Published: March 2022

Kampus merupakan salah satu entitas penting yang menunjang pariwisata di Garut. Mutu pelayanan kampus di antaranya dipengaruhi oleh penerapan teknologi informasi. Salah satu komponen teknologi informasi yang diterapkan di kampus adalah jaringan komputer. Penelitian ini bertujuan untuk merancang arsitektur jaringan komputer dengan metode Network Development Life Cycle yang meliputi tahap analisis, perancangan, dan simulasi. Penelitian berhasil merancang tata letak jaringan sesuai kebutuhan dan jaringan yang ada. Simulasi menunjukkan ada perubahan kondisi jaringan menjadi sesuai dengan kebutuhan. Manajemen bandwidth diterapkan sesuai kebutuhan pengguna dan rancangan desain infrastruktur jaringan sesuai perkembangan teknologi informasi saat ini. oleh karena itu perlu dilakukan perancangan arsitektur jaringan kampus.
ANTROPOCENE: la “salute” del villaggio globale e il “Cigno Nero”
Authors: Capitanini Alessandro
Published: March 2022

Over the past three centuries, the effects of humans on the global environment have increased. It seems appropriate to assign the term “Anthropocene” to the current geological epoch, which is in many ways dominated by humans. The Anthropocene can be said to have begun in the latter part of the 18th century, when analyses of air trapped in polar ice showed the beginning of the rise in global concentrations of carbon dioxide and methane. This date also coincides with the design of the steam engine by James Watt in 1784. In particular, the 21st century witnessed an unforeseen but predictable resurgence of infectious diseases, not least the COVID-19 pandemic, which had a devastating impact on lives and livelihoods worldwide. The 2003 severe acute respiratory syndrome coronavirus outbreak, the 2009 swine flu pandemic, the 2012 Middle East respiratory syndrome coronavirus outbreak, and the 2013-2016 Ebola virus outbreak in West Africa all caused significant morbidity and mortality as they spread through the global village across borders to infect people in multiple countries. In the last 70 years, the speed at which human habits have changed through technological, demographic and climatic changes is unprecedented: airline flights have doubled since 2000, more people live in urban than rural areas since 2007, climate change poses a growing threat to society, and humans have stopped following the high road shown by nature with proper nutrition and regular exercise. In this review, we consider the extent to which these recent global changes have increased the risk of infectious disease outbreaks, even though improved sanitation and access to health care have led to significant progress worldwide.
ONTOLOJİK VE EPİSTEMOLOJİK TEMELLERİYLE SADRÜŞŞERÎA’DA MÜRECCİH KAVRAMI: FÂİLİN VE MÜÇTEHİDİN FİİLİNE ETKİSİ
Authors: GÜLDÜ Şule
Published: March 2022

Müçtehit usûl-i fıkıh ile bilgi üretirken konu, zaman ve yön birliği bulunan deliller ile farklı hükümlere varabilir ve ortaya çelişki çıkabilir. Müçtehit bu çelişkiyi ortadan kaldırmak için farklı yollar izler. Bu yollardan biri olarak, çelişki ortaya çıkaran delillerden birini tercih edebilir. Çünkü bu delil kendisinde var olan ayırıcı bir özellik yani müreccih sebebiyle diğerine üstün gelir. Fıkıh ilminde müreccih, müçtehitlerin çoğu tarafından tercih işleminde bir şart olarak aranır. Kavram yakın bir anlam karşılığıyla kelam ve felsefede de kullanılır. Bu ilimlerde fâilin fiilini işlemeye yönelmesinde, onu bu fiile çeken bir sebebin/müreccihin bulunup bulunmadığı tartışılır. Söz konusu disiplinlerde de bu durum “tercih bilâ müreccih caiz değildir” argümanı ile ifade edilir. Bu çalışmanın amacı genel olarak bu argümanın arka planındaki tartışmaları aktarmak, özel olarak ise Sadrüşşerîa’nın fiilin meydana gelmesinde müreccih kavramına yüklediği fonksiyonu hem müçtehidin hem de fâilin fiili üzerinden takip etmektir. Bu bağlamda giriş kısmında kavramın gerek kelam ve felsefede gerek usûl-i fıkıh disiplinlerinde ilişkili olduğu meseleler kısaca anlatılmaktadır. Giriş kısmından sonra kavramın epistemolojik ve ontolojik arka planı verilmeye çalışılmıştır. Ardından farklı bakış açısı nedeniyle Sadrüşşerîa’nın ontolojik düzlemde meseleyi ele alışı incelenmektedir. Daha sonra Sadrüşşerîa’nın fıkhî bilginin üretilmesinde kavramı nasıl kullandığı aktarılmıştır. Konunun teorik kısmı ön planda tutulduğu için metnin akışını bozmamak amacıyla örnekler gerekli görüldüğü kadar verilmiştir.
Using Walnut Shell Based Activated Carbon for the Efficient Removal of Phosphate from Aqueous Solutions
Authors: ARSLAN Ayla , ZEYBEK Şehriban
Published: March 2022

In this study, walnut shell, which is abundant in Turkey and low-cost biomass waste, has been used for activated carbon production and phosphate removal from aqueous solutions with the produced activated carbon was investigated. ZnCl2 was used to prepare adsorbent by chemical activation method. Produced activated carbons were characterized by moisture content, ash content, iodine number, Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM) analyses. The specific surface area was calculated as 415.433 m2/g from the isotherms using the Brunauer-Emmett-Teller (BET) equation. The effects of pH, adsorbent amount, agitation speed and temperature were investigated. Different adsorption isotherm models were applied. It was found that the Langmuir isotherm provided the best fit for the experimental data. In the pseudo- second order kinetic model, the values found theoretically (qe,cal) were very similar to those determined by experiments (qe,exp). The results showed that the adsorption of phosphate on the WSAC fits the pseudo- second order kinetic model. According to the thermodynamics analysis, phosphate adsorption on WSAC was endothermic under the studied conditions.
PERANCANGAN TATA KELOLA TEKNOLOGI INFORMASI DI POLITEKNIK LAMANDAU MENGGUNAKAN FRAMEWORK COBIT 5
Authors: Faizal Faizal
Published: March 2022

Tata kelola teknologi informasi (IT Governance) di perguruan tinggi dewasa ini dibutuhkan agar pengembangan investasi dan penerapan teknologi informasi yang dimiliki menjadi maksimal nilainya. Tata kelola teknologi informasi merupakan aspek yang memengaruhi kualitas sebuah institusi. Politeknik Lamandau sebagai perguruan tinggi berkembang saat ini belum memiliki konsep dalam pengelolaan tata kelola teknologi informasi yang baik untuk menciptakan keselarasan aktivitas bisnis sehingga kerap menemui masalah dalam integrasi system TI . Model tata kelola TI yang tepat bagi suatu perguruan tinggi harus sejalan dengan tujuan tata kelola TI yaitu mampu menyelaraskan strategi TI dengan strategi bisnis yang ada pada perguruan tinggi, maka diperlukan rancangan model yang berguna untuk mengarahakan intitusi menuju Good University Governance sesuai dengan tujuan TI. Penelitian berkontribusi pada penggunaan COBIT 5 dan konsep IT Goals sebagai model perancangan tata kelola TI pada sektor pendidikan tinggi untuk mengarahkan institusi pada konsep Good University Governance. Hasil pengujian pada framework yang telah dirancang menggunakan metode user acceptance menunjukkan bahwa 90% stakeholder Politeknik Lamandau mengatakan bahwa framework tata kelola TI layak diterapkan.
SISTEM PAKAR UNTUK MENDETEKSI GANGGUAN KEHAMILAN MENGGUNAKAN METODE FORWARD CHAINING
Authors: Maulana Arlan
Published: March 2022

Sistem pakar merupakan salah satu aplikasi dari kecerdasan buatan (Artificial Intelligence). Sistem pakar merupakan implementasi dari ilmu seorang pakar yang dibuat ke dalam suatu sistem untuk bisa membantu dalam menyelesaikan masalah atau menemukan diagnosa terkait hal-hal yang hanya bisa ditentukan oleh seorang pakar. Penelitian ini mengangkat permasalahan mengenai gangguan/kelainan penyakit yang diderita ibu hamil, dibantu dengan teknologi sistem cerdas yang dapat memberikan pengetahuan mengenai gejala dan kebiasaan apa yang menyebabkan ibu hamil bisa rentan terkena kelainan dan gangguan pada janin yang tengah dikandungnya berdasarkan ketentuan/rule yang telah ditentukan. Membantu ibu hamil dalam mengetahui kondisi kesehatannya lewat kondisi per-trimester. Sistem juga dapat memberikan informasi sekaligus bantuan berupa saran yang bisa diikuti oleh calon ibu ketika kondisi kehamilannya mungkin terdapat sedikit gangguan, secara tidak langsung sistem memberikan pertolongan pertama bagi calon ibu. Menggunakan metode  forward chaining, metode ini menggunakan kaidah pencarian serta penarikan hasil berupa kesimpulan yang ada berdasarkan rules, prosesnya dimulai dari fakta yang ada lalu diproses melalui premis-premis untuk menuju pada kesimpulan atau yang biasa disebut bottom up reasoning. Forward chaining dimulai melalui pencarian dari satu masalah sampai kepada solusinya. Apabila klausa premis sesuai dengan kondisi, maka proses akan memberikan hasil berupa kesimpulan.  Diimplementasikan dalam sebuah sistem berbasis website agar para ibu hamil dapat melakukan konsultasi mandiri dimanapun dan kapanpun, dengan adanya sistem ini berguna untuk para ibu hamil yang ingin mengetahui kondisi kesehatan kandungannya tanpa perlu konsultasi langsung pada dokter kandungan setiap sebulan sekali.
SIMPLIFIKASI MODEL CV BERPADU OPERASI MORFOLOGI UNTUK DETEKSI OBJEK KANKER PADA CITRA USG
Authors: Anan Nugroho  , Fauzi Anas , Sunarko Budi , Wibawanto Hari , Iksan Nur
Published: March 2022

Saat ini, Computer Aided Diagnosis (CAD) tengah dikembangkan secara masif sebagai second opinion reader di berbagai modalitas pencitraan medis, salah satunya ultrasonografi (USG). Untuk skrining otomatis citra USG yang banyak, berulang-ulang dan terus-menerus, teknik deteksi objek memainkan peran krusial pada sistem CAD. Deteksi objek kanker pada citra USG tidak mudah karena objek-objek tersebut berkontras rendah dan bertepi kabur akibat gangguan derau speckle dan artifak. Studi ini mengatasi tantangan ini dengan mengusulkan metode deteksi berbasis model active-contour Chan-Vese (CV) tersimplifikasi diikuti operasi morfologi. Adapun performa kuantitatif diperoleh menggunakan skor Intersection of Union (IoU) antara objek-objek terdeteksi dengan ground truth-nya. Usulan metode divalidasi menggunakan 20 citra USG tiroid dan payudara dengan hasil rerata skor IoU mencapai 92,36%. Performa yang menjanjikan ini menunjukkan bahwa usulan metode layak diimplementasikan pada sistem CAD.
Impact of COVID on Professionals Addressing Psychosocial Needs of People With Diabetes: An International Survey
Authors: Wagner Julie , Cummings Caroline , Feinn Richard , Kanc Karin , Kos Miha
Published: March 2022

We investigated how COVID-19 has disrupted the work of health professionals who address behavioral and psychosocial needs of people with diabetes (PWD). English language emails were sent to members of five organizations that address psychosocial aspects of diabetes, inviting them to complete a one-time, anonymous, online survey. On a scale from 1=no problem, to 5=serious problem, respondents reported problems with the healthcare system, their workplaces, technology, and concerns about the PWD with whom they work. Respondents (n=123) were from 27 countries, primarily in Europe and North America. The typical respondent was a woman, aged 31-40 years, who worked in an urban hospital in medicine or psychology/psychotherapy. Most judged that the COVID lockdown in their region was moderate or severe. Over half felt moderate to serious levels of stress/burnout or mental health issues. Most participants reported moderate to severe problems due to the lack of clear public health guidelines, concerns with COVID safety of themselves, PWD, and staff, and a lack of access or knowledge on the part of PWD to use diabetes technology and telemedicine. In addition, most participants reported concerns with the psychosocial functioning of PWD during the pandemic. Overall, the pattern of findings reveals a high level of detrimental impact, some of which may be ameliorated with changes in policy and additional services for both health professionals and the PWD with whom they work. Concerns about PWD during the pandemic must go beyond their medical management and also consider the health professionals who provide them with behavioral and psychosocial support.
Development and Validation of Ischemic Events Related Signature After Carotid Endarterectomy
Authors: Guo Chunguang , Liu Zaoqu , Cao Can , Zheng Youyang , Lu Taoyuan , Yu Yin , Wang Libo , Liu Long , Liu Shirui , Hua Zhaohui , Han Xinwei , Li Zhen
Published: March 2022

Background: Ischemic events after carotid endarterectomy (CEA) in carotid artery stenosis patients are unforeseeable and alarming. Therefore, we aimed to establish a novel model to prevent recurrent ischemic events after CEA.

Methods: Ninety-eight peripheral blood mononuclear cell samples were collected from carotid artery stenosis patients. Based on weighted gene co-expression network analysis, we performed whole transcriptome correlation analysis and extracted the key module related to ischemic events. The biological functions of the 292 genes in the key module were annotated via GO and KEGG enrichment analysis, and the protein-protein interaction (PPI) network was constructed via the STRING database and Cytoscape software. The enrolled samples were divided into train (n = 66), validation (n = 28), and total sets (n = 94). In the train set, the random forest algorithm was used to identify critical genes for predicting ischemic events after CEA, and further dimension reduction was performed by LASSO logistic regression. A diagnosis model was established in the train set and verified in the validation and total sets. Furthermore, fifty peripheral venous blood samples from patients with carotid stenosis in our hospital were used as an independent cohort to validation the model by RT-qPCR. Meanwhile, GSEA, ssGSEA, CIBERSORT, and MCP-counter were used to enrichment analysis in high- and low-risk groups, which were divided by the median risk score.

Results: We established an eight-gene model consisting of PLSCR1, ECRP, CASP5, SPTSSA, MSRB1, BCL6, FBP1, and LST1. The ROC-AUCs and PR-AUCs of the train, validation, total, and independent cohort were 0.891 and 0.725, 0.826 and 0.364, 0.869 and 0.654, 0.792 and 0.372, respectively. GSEA, ssGSEA, CIBERSORT, and MCP-counter analyses further revealed that high-risk patients presented enhanced immune signatures, which indicated that immunotherapy may improve clinical outcomes in these patients.

Conclusion: An eight-gene model with high accuracy for predicting ischemic events after CEA was constructed. This model might be a promising tool to facilitate the clinical management and postoperative surveillance of carotid artery stenosis patients.
Syntheses, Characterizations, and Inhibition Activities Against Coxsackievirus B3 of Iodobenzoic Hydrazide Functionalized Hexamolybdates
Authors: Wang Long-Sheng , Guo Chao , Hu Da , Zhao Yan-Xi , Liu Hui-Hui , Dong Yu-Jia , Sun Shang-Bin , Liu Xing , Hu Kang-Hong , Wei Yan-Hong
Published: March 2022

A class of iodobenzoyldiazenido-functionalized POMs (TBA)3 [Mo6O18(=N=NCOAr)] (Ar = Ph-o-I (1); Ph-m-I (2); Ph-p-I (3); Ph-3,4-I2(4); Ph-2,3,5-I3(5) (TBA = tetrabutylammonium) were prepared via the refluxing reaction of α-octamolybdates, DCC, and corresponding hydrazides in dry acetonitrile. Their structures were determined by Fourier-transform infrared spectroscopy, ultraviolet–visible spectra, X-ray photoelectron spectroscopy, hydrogen-1 nuclear magnetic resonance, and high-resolution mass spectrometry. Research on the biological activity of title compounds shows that L3, L5, 3, and 5 demonstrate potent inhibitory activity against coxsackievirus B3 and low in vitro cytotoxic activity against Hep-2 cell lines. The covalent linkage between the iodobenzoyldiazenido components and POMs can enhance the molecular inhibitory efficiency of iodobenzohydrazides.
Study of Relaxations in Epoxy/Rubber Composites by Thermally Stimulated Depolarization Current and Dielectric Spectroscopy
Authors: Wang Chuang , Zhou Gang , Zhu Weiyu , Chen Chi , Fu Yuwei , Zhang Zaiqin , Li Hui
Published: March 2022

Liquid rubber toughened epoxy resins are widely used in electrical equipment and electronic packaging. Previous studies have only investigated the relaxation process of epoxy resins through dielectric spectroscopy. The trap characteristics of the relaxation process by thermally stimulated depolarization current (TSDC) analysis are less studied. In this work, TSDC and broadband dielectric spectroscopy techniques were used to complementarily characterize the dielectric relaxation process of hydroxyl-terminated liquid nitrile-butadiene rubber (HTBN) toughened epoxy resin polymers. The experimental results show that HTBN introduces two new relaxation processes in the epoxy matrix, which are attributed to the α polarization of the rubber molecule and the interfacial polarization based on the correlation between the TSDC and the dielectric spectroscopy data, respectively. The trap parameters of each TSDC current peak were obtained using the multi-peak fitting method. The addition of rubber increases the trap density in epoxy composites significantly, especially for traps with energy levels in the range of 0.5–0.9 eV. The trap energy level of the DC conductivity process increases with increasing rubber concentration. The above results provide analytical ideas for rubber-toughened epoxy resins’ polarization and trap characteristics and theoretical guidance for formulation improvement.
The Collateral Effects of COVID-19 Pandemic on the Status of Carbapenemase-Producing Pathogens
Authors: Ayoub Moubareck Carole , Hammoudi Halat Dalal
Published: March 2022

The serious challenge of antimicrobial resistance continues to threaten public health and lingers in the era of the coronavirus disease 2019 (COVID-19), declared pandemic by the World Health Organization. While the pandemic has triggered the importance of infection control practices and preventive measures such as physical distancing, hand hygiene, travel reduction and quarantine, the ongoing alarm of antimicrobial resistance seems to accompany the pandemic too. Antimicrobial resistance has been fostered during COVID-19, possibly due to high rate of empirical antibiotic utilization in COVID-19 patients, increased use of biocides, and the disruption of proper healthcare for other conditions. Specifically, carbapenemase-producing Gram-negative bacteria have shown to cause secondary bacterial infections in patients hospitalized for COVID-19. Clinical and microbiological evidence of such infections is accumulating in different parts of the world. With the resilient nature of carbapenemases, their association with mortality, and the limited treatment options available, concerns regarding this group of antibiotic-hydrolyzing enzymes during the pandemic are expected to upsurge. While the additional burden carbapenemases exert on healthcare is worrisome, it remains hidden or abandoned among the various health consequences of the pandemic. The purpose of this minireview is to shed a light on carbapenemase-associated infections during such unprecedented time of COVID-19. A focused insight shall be made into carbapenemases, their implications for COVID-19 patients, and the features and consequences of co-infection, with a review of available evidence from pertinent literature. The importance of increased surveillance for carbapenemase-producers and optimizing their management in relation to the pandemic, shall be addressed as well.
Toll-Like Receptor 2 Modulates Pulmonary Inflammation and TNF-α Release Mediated by Mycoplasma pneumoniae
Authors: Chen Ming , Deng Huan , Zhao Yue , Miao Xueqing , Gu Haiyan , Bi Ying , Zhu Yifan , Guo Yun , Shi Shuang , Xu Jiejing , Zhao Deyu , Liu Feng
Published: March 2022

Objectives

To investigate the roles that Toll-like receptors (TLRs) play in lung inflammation mediated by Mycoplasma pneumoniae (MP).

Methods

The changes in TLRs and tumor necrosis factor alpha (TNF-α) in peripheral blood of children with M. pneumoniae pneumonia (MPP) were monitored, and the interactions of signaling molecules regulating TNF-α release in A549 cells and neutrophils after M. pneumoniae stimulation were investigated. In TLR2 knockout (TLR2-/-) mice, the levels of TNF-α in bronchial alveolar lavage fluid (BALF) and peripheral blood after mycoplasma infection and the pathological changes in the lung tissue of mice were detected.

Results

TNF-α levels in peripheral blood of children with MPP were higher than those in non-infected children, and children with refractory MPP had the highest levels of TNF-α and TLR2. TNF-α secretion and TLR2, myeloid differentiation primary response 88 (MyD88) and phospho-p65(p-p65) levels were increased in stimulated cells. TNF-α secretion was suppressed upon siRNA-mediated TLR2 silencing. Pharmacological inhibition of nuclear factor-kappa B (NF-κB) and MyD88 effectively reduced TNF-α expression. Compared with wild-type mice, the TNF-α in serum and BALF decreased, and lung pro-inflammatory response was partially suppressed in TLR2-/- mice.

Conclusion

We concluded that TLR2 regulates M. pneumoniae-mediated lung inflammation and TNF-α release through the TLR2-MyD88-NF-κB signaling pathway.
High Plasma sTNF-R1 Level Is Related to Loss of Natural HIV Control in Long-Term Elite Controllers
Authors: Sepúlveda-Crespo Daniel , Rallón Norma , Muñoz-Gómez María José , Brochado-Kith Oscar , Jiménez José Luis , Muñoz-Fernández María Ángeles , Benito José M. , Resino Salvador
Published: March 2022

Human immunodeficiency virus-1 (HIV-1) elite controllers are heterogeneous due to different immunovirological features. We aimed to identify plasma biomarkers associated with loss of spontaneous HIV-1 control in long-term elite controllers (HIV-LTECs). We performed a retrospective study in 60 HIV-LTECs [36 true-LTECs and 24 LTECs losing control (LTECs-LC)]. We selected a plasma sample from true-LTECs (towards the middle of the follow-up period) and two samples from LTECs-LC (one far from the loss of control and another close to loss of control). Plasma biomarkers were evaluated using multiplex immunoassays. The partial least squares-discriminant analysis provided the variable importance in projection (VIP), and the adjusted Generalized Linear Model provided the adjusted arithmetic mean ratio (aAMR). At the moment of the first LTECs-LC samples, the only plasma biomarker with a VIP≥1.5 was sTNF-R1, which showed higher values in LTECs-LC than true-LTECs [aAMR=1.62 (95%CI=1.20-2.19); p=0.001]. After a median of 3.9 (IQR=4.5) years of follow-up from the first sample, we also had access to a second plasma sample from 10 LTECs-LC patients. At the moment of this second LTECs-LC sample, the only plasma biomarker with VIP≥1.5 was also sTNF-R1, which showed higher values in LTECs-LC than true-LTECs [aAMR=1.93 (95%CI=1.41-2.65); p<0.001]. The difference between the first and second samples of LTECs-LC was significant (Δx= 6.58 (95%=0.3; 12.88); p=0.040). In conclusion, high plasma values of sTNF-R1 appear to discriminate HIV-LTECs that lose the natural control of HIV-1, helping to define a specific phenotype that may be useful for the clinical management of these patients.
Effect of Asymptomatic Hyperuricemia on Mortality of Elderly Patients After Elective Percutaneous Coronary Intervention
Authors: Chen Chen , Dong Jianzeng , Lv Qiang , Liu Xinmin , Zhang Qian , Du Xin
Published: March 2022

Purpose

The purpose of this study is to investigate the effect of asymptomatic hyperuricemia on mortality of elderly patients with coronary artery disease (CAD) after elective percutaneous coronary intervention (PCI).

Methods

One thousand two hundred ninety-six patients with coronary heart disease ≥65 years old who had increased uric acid records and without gout history underwent elective PCI from January 2015 to January 2016 were enrolled. The hyperuricemia is defined as serum uric acid level >420 μ mol/l (7 mg/dl) for males and >357 μ mol/l (6 mg/dl) for females. Patients were divided into hyperuricemia group and non-hyperuricemia group. After an average of 519 days follow-up, the differences in mortality between the two groups were compared.

Results

There were 236 patients in hyperuricemia group and 1060 patients in non-hyperuricemia group. In hyperuricemia group, BMI was higher (P = 0.036); the proportions of patients with hypertension (P < 0.001) and myocardial infarction history (P = 0.046) were higher; white blood cells (P = 0.015) and triglyceride levels were higher (P < 0.001); and estimated glomerular filtration rate (P < 0.001) and high-density lipoprotein cholesterol level were lower (P = 0.007). In addition, in hyperuricemia group, during hospitalization, the ratios of patients treated with diuretics (P < 0.001) and the number of PCI lesions were higher (P = 0.030), and the complete revascularization rate was lower (P = 0.017). The mortality rate (2.2 vs. 7.6%, P < 0.001) of hyperuricemia group was significantly higher than that of non-hyperuricemia group. Multivariate Cox regression analysis showed that after adjusting for other factors, hyperuricemia was an independent risk factor for increased mortality after PCI (HR 2.786, 95% CI 1.233–6.297, P = 0.014).

Conclusion

Asymptomatic hyperuricemia is an independent risk factor for increased mortality of elderly patients with coronary heart disease undergoing elective PCI.
Right Ventricular Function Improves Early After Percutaneous Mitral Valve Repair in Patients Suffering From Severe Mitral Regurgitation
Authors: Neuser Jonas , Buck Hans Julian , Oldhafer Maximiliane , Sieweke Jan-Thorben , Bavendiek Udo , Bauersachs Johann , Widder Julian D. , Berliner Dominik
Published: March 2022

Background

Percutaneous mitral valve edge-to-edge procedure (PMVR) using the MitraClip® system (Abbot Vascular, CA) is an established therapy for severe mitral regurgitation (MR) in patients judged inoperable or at high surgical risk. Besides determining exercise capacity, right ventricular (RV) function has prognostic value in heart failure and after cardiac surgery. We therefore investigated the impact of PMVR on RV function in patients with severe MR.

Methods and Results

Sixty-three patients undergoing PMVR at our department were prospectively enrolled. Transthoracic echocardiography was performed before, early (2–12d) after PMVR and after 3 months, including advanced echocardiographic analyses such as 3D imaging and strain analyses. At baseline, all patients presented with advanced heart failure symptoms. Etiology of MR was more often secondary and, if present, left ventricular (LV) dysfunction was predominantly caused by ischemic cardiomyopathy. PMVR substantially reduced MR to a grade ≤ 2 in most patients. Echocardiographic assessment revealed a largely unchanged LV systolic function early after PMVR, while in contrast RV function substantially improved after PMVR [3D RV EF (%): pre 33.7% [27.4; 39.6], post 40.0% [34.5; 46.0] (p < 0.01 vs. pre), 3 months 42.8% [38.3; 48.1] (p < 0.01 vs. pre); 2D RV GLS (%): pre −12.9% [−14.5; −10.5], post −16.0% [−17.9; −12.6] (p < 0.01 vs. pre), 3 months −17.2% [−21.7; −14.9] (p < 0.01 vs. pre)]. Factors that attenuated RV improvement were larger ventricular volumes, lower LV function, secondary MR, and a higher STS score (all p < 0.05).

Conclusion

By using advanced echocardiographic parameters, we discovered an early improvement of RV function after PMVR that is preserved for months, independent from changes in LV function. Improvement of RV function was less pronounced in patients presenting with an advanced stage of heart failure and a higher burden of comorbidities reflected by the STS score.
Educating Through Attentional States of Consciousness, an Effective Way to Develop Creative Potential?
Authors: Rebecchi Kevin , Hagège Hélène
Published: March 2022

Researchers have recently turned their focus to a specific area: the links between altered states of consciousness and creativity. A spectrum of attentional states of consciousness exists, from hypnagogia and mind wandering to mindfulness and flow. These attentional states of consciousness are present during a variety of activities (e.g., sports, music, painting, writing, video games, theater, and meditation) as well as in situations characterized by boredom. They are also present in many professional fields and practices (e.g., education and teaching). Moreover, researchers and educators focus sometimes on only one state of consciousness (such as mind wandering) or only on attention, and do not question relationships with others (such as mindfulness or flow) or the links with intention, the different levels of consciousness involved and the changes in perception of time, self and space. Additionally, as we know that a state of consciousness rarely occurs alone or that it can have two forms (such as spontaneous and deliberate mind wandering), we propose a global approach allowing to grasp the stakes and perspectives of what we call attentional states of consciousness. Thus, to our knowledge, this is the first theoretical review highlighting the historical, empirical, theorical and conceptual relationships between creativity, attention, mind wandering, mindfulness and flow by offering concrete and empirical avenues and bases for reflection about educating for creativity and developing creative potential.
Satisfying the Need for Relatedness Among Teachers: Benefits of Searching for Social Support
Authors: Maas Jasper , Schoch Simone , Scholz Urte , Rackow Pamela , Schüler Julia , Wegner Mirko , Keller Roger
Published: March 2022

The satisfaction of teachers’ need for relatedness is an important pre-condition for teachers’ wellbeing. Receiving social support plays an important role in satisfying the need for relatedness. Following job crafting theory, the present study aims to examine (1) whether searching for social support results in an increase in the satisfaction of the need for relatedness and (2) whether this effect is mediated by an increase of received social support from the school principal and from colleagues. Using longitudinal data (N = 1071) we calculated residualized change scores and applied structural equation modeling to test the hypothesized mediation model. Results confirmed the beneficial effect of searching for social support on the satisfaction of the need for relatedness. This effect included a direct effect and an indirect effect through the receipt of social support from colleagues. The receipt of social support from the school principal was positively related to searching for social support but was unrelated to the satisfaction of the need for relatedness. These findings emphasize the importance that teachers build strong and supportive relationships within the school team, as this helps to satisfy their need for relatedness, which in turn contributes to better wellbeing among teachers.
Transcriptome Analysis Reveal Candidate Genes and Pathways Responses to Lactate Dehydrogenase Inhibition (Oxamate) in Hyperglycemic Human Renal Proximal Epithelial Tubular Cells
Authors: Wang Zhimin , Hao Dan , Fang Dong , Yu Jiating , Wang Xiao , Qin Guijun
Published: March 2022

Diabetic kidney disease (DKD) is the leading cause of both chronic kidney disease (CKD) and end-stage renal disease (ESRD). Previous studies showed that oxamate could regulate glycemic homeostasis and impacted mitochondria respiration in a hyperglycemia-dependent manner in the rat proximal tubular cells. To explore the transcriptome gene expression profiling of kidney tissues in human renal proximal epithelial tubular cell line (HK-2), we treated HK-2 cells with high D-glucose (HG) for 7 days before the addition of 40 mM oxamate for a further 24 hours in the presence of HG in this study. Afterwards, we identified 3,884 differentially expressed (DE) genes based on adjusted P-value ≤ 0.05 and investigated gene relationships based on weighted gene co-expression network analysis (WGCNA). After qRT-PCR validations, MAP1LC3A, MAP1LC3B (P-value < 0.01) and BECN1 were found to show relatively higher expression levels in the treated groups than the control groups, while PGC1α (P-value < 0.05) showed the lower expressions. Accordingly, enrichment analyses of GO terms and KEGG pathways showed that several pathways [e.g., lysosome pathway (hsa04142) and p53 signaling pathway (hsa04115)] may be involved in the response of HK-2 cells to oxamate. Moreover, via WGCNA, we identified two modules: both the turquoise and blue modules were enriched in pathways associated with lysosome. However, the p53 signaling pathway was only found using all 3,884 DE genes. Furthermore, the key hub genes IGFBP3 (adjusted P-value = 1.34×10-75 and log2(FC) = 2.64) interacted with 6 up-regulated and 12 down-regulated DE genes in the network that were enriched in the p53 signaling pathway. This is the first study reporting co-expression patterns of a gene network after lactate dehydrogenase inhibition in HK-2 cells. Our results may contribute to our understanding of the underlying molecular mechanism of in vitro reprogramming under hyperglycemic stress that orchestrates the survival and functions of HK-2 cells.
MOTS-c and Exercise Restore Cardiac Function by Activating of NRG1-ErbB Signaling in Diabetic Rats
Authors: Li Shunchang , Wang Manda , Ma Jiacheng , Pang Xiaoli , Yuan Jinghan , Pan Yanrong , Fu Yu , Laher Ismail
Published: March 2022

Pathologic cardiac remodeling and dysfunction are the most common complications of type 2 diabetes. Physical exercise is important in inhibiting myocardial pathologic remodeling and restoring cardiac function in diabetes. The mitochondrial-derived peptide MOTS-c has exercise-like effects by improving insulin resistance, combatting hyperglycemia, and reducing lipid accumulation. We investigated the effects and transcriptomic profiling of MOTS-c and aerobic exercise on cardiac properties in a rat model of type 2 diabetes which was induced by feeding a high fat high sugar diet combined with an injection of a low dose of streptozotocin. Both aerobic exercise and MOTS-c treatment reduced abnormalities in cardiac structure and function. Transcriptomic function enrichment analysis revealed that MOTS-c had exercise-like effects on inflammation, myocardial apoptosis, angiogenesis and endothelial cell proliferation and migration, and showed that the NRG1-ErbB4 pathway might be an important component in both MOTS-c and exercise induced attenuation of cardiac dysfunction in diabetes. Moreover, our findings suggest that MOTS-c activates NRG1-ErbB4 signaling and mimics exercise-induced cardio-protection in diabetes.