bluuebunny/crossref_metadata_2025 huggingface dataset:
The C-reactive protein to albumin ratio is a novel prognostic factor in patients with stable coronary artery disease following percutaneous coronary intervention
Authors: Zou Yang , Zhong Mingchun , Zeng Hui , Chen Xiaohua , Sheng Guotai
Published: June 2020

Background

Previous studies have shown that both C-reactive protein (CRP) and albumin (Alb) are the prognostic factors of cardiovascular. However, the prognostic value of C-reactive protein to albumin ratio (CAR) in patients with stable coronary artery disease (SCAD) is unclear.
Methods

This was a retrospective cohort study that continuously enrolled 204 patients with newly diagnosed SCAD between October 2014 and October 2017; the mean follow-up time was 793.75 ± 430.26 days. The Cox proportional hazard model was used to evaluate the prognostic value of CAR in patients with SCAD.
Results

In the Kaplan–Meier analysis, the long-term MACE (major adverse cardiac events) free survival rate of patients with high CAR levels decreased significantly (P = 0.015). Of the note, after adjusting for other covariates in multivariate analysis, CAR was still independently positively correlated with poor prognosis in SCAD patients (HR = 1.03, 95% CI:1.01–1.06, P = 0.02, P for trend = 0.024). Additionally, we identified a nonlinear association between CAR and poor prognosis of SCAD by the generalized additive model (GAM). Then, through the two-piecewise linear regression model, we calculated that the inflection point of CAR was 3.933 (log-likelihood ratio test P = 0.02). When CAR ≤ 3.933, there was a positive correlation between CAR and MACE in patients with SCAD (HR:1.48, 95% CI:1.10–1.99, P = 0.009). While on the right hand of the inflection point (CAR > 3.933), the positive correlation between the two tends to be saturated (HR:1.01, 95% CI:0.97–1.05, P = 0.64).
Conclusions

This study indicated an association between higher CAR levels and increased risk of MACE in patients with SCAD for the first time, and measurement of CAR at admission may be a valuable predictor of the prognostic outcome in patients with SCAD treated by the percutaneous coronary intervention.
Exploration to the Application of Hybird Technology in Special Types of Congenital Heart Diseases in Children
Authors: Liu Yuhang , Wang Ning , Wen Ping
Published: June 2020

Background

Hybrid technology has become a hot topic in cardiovascular surgery,has been widely used in the minimally invasive closure of simple coronary heart diseases (CHDs). For some children with special CHDs, it is still impossible to avoid the huge trauma caused by cardiopulmonary bypass. This study aimed to investigate the feasibility、safety and efficacy of hybrid technology in the treatment of several specific CHDs.
Methods

A total of 29 children with specific CHDs hospitalised in the Cardiac Surgery Department of Dalian Children’s Hospital from July 2014 to June 2019 were enrolled. There were 2 cases of right coronary artery-right ventricular fistula, 17 cases of neonatal critical pulmonary stenosis (CPS), 9 cases of neonatal pulmonary atresia-intact ventricular septum (PA/IVS), and 1 case of giant aortopulmonary window (APW). All of them underwent surgical treatment with hybrid technology guided by transoesophageal echocardiography (TEE). The TEE enabled immediate evaluation of the surgical curative effect. Further chest X-ray, electrocardiogram (ECG) and echocardiogram were performed in the outpatient department after discharge.
Results

The surgical treatment with hybrid technology was smooth except that 1 CPS patient was converted to open-heart surgery with cardiopulmonary bypass (CPB) due to a torn right ventricular outflow tract after balloon dilatation. No complication, such as wound or intracardiac infection, arrhythmia or pericardial effusion occurred. No children have been lost to follow-up and the investigation results and prognosis remain satisfactory.
Conclusions

the use of hybrid technology is a safe and effective alternative therapy for specific paediatric CHD cases. It has significant advantages in alleviating trauma and reducing medical costs and, therefore, has good prospects for broad application in the future.
Job Satisfaction and Self-Perceived Health Status among Primary Care Providers in China
Authors: Wang Jun , Zhu Jingmin , Liang Hailun
Published: June 2020

Background: Healthcare providers’ health and safety can influence the quality of patient care. The attitude towards work, either satisfaction or dissatisfaction, could influence the way in which people perceive their health status. To check this hypothesis, some studies have shown an association between healthcare providers’ health status and job satisfaction. The present study examined the associations between self-perceived health status and job satisfaction among primary care providers in China, and the moderating effect of job type.Methods: Data were collected by using questionnaire survey among Chinese primary care providers, who work for general practice teams (GPTs). The GPT members’ self-perceived health, job satisfaction, and job type were evaluated, where job satisfaction comprised work, promotion and training, and work environment. Multivariate logistic regression analysis was performed.Findings: Of the 536 participants, 48.51% reported good physical health, and 55.78% reported good mental health. Participants reported being moderately satisfied with their job. Self-perceived physical and mental health were significantly and positively associated with job satisfaction in similar magnitudes. Promotion and training satisfaction were more strongly associated with physical health, whereas work environment had the strongest association with mental health. Job type moderated this association, wherein the association was significant only for non-general practitioners (non-GPs).Conclusion: Primary care providers’ job satisfaction is significantly associated with their self-perceived health. Actions are needed to increase their job satisfaction and therefore to improve their health. Meanwhile, further research into GPs’ health determinants is needed.
A survival analysis of COVID-19 in the Mexican population
Authors: Salinas-Escudero Guillermo , Carrillo-Vega María Fernanda , Granados-García Víctor , Martínez-Valverde Silvia , Toledano-Toledano Filiberto , Garduño-Espinosa Juan
Published: June 2020

Background. At present, the Americas region contributes to the largest number of cases of COVID-19 worldwide. In this area, Mexico is in third place respecting deaths (20,781 total deaths), rate that may be explained by the high proportion of the population over 50 years and the rate of chronic diseases. The aim of the present work was estimate the risk factors associated with the death rate, considering the time between symptoms onset and the death occurrence, in the Mexican population. Methods. Information of all the confirmed cases for COVID-19 reported on the public dataset released by the Epidemiological Surveillance System for Viral Respiratory Diseases of the Mexican Ministry of Health was analyzed. Kapplan-Meier curves were plotted, and a Cox proportional hazard model was constructed. Results. The analysis included 16,752 registries of confirmed cases of COVID-19 with mean age 46.55±15.55 years; 58.02% (n=9719) men and 9.37% (n=1,569) died. Men (H.R. 1.21, p<0.01, 95% C.I. 1.09-1.35), older age (H.R. 8.24, p<0.01, 95% C.I. 4.22-16.10), CKD (H.R. 1.85, p<0.01, 95% C.I. 1.51-2.25), pneumonia (H.R. 2.07, p<0.01, 95% C.I. 1.81-2.38), hospitalization and ICU admissions (H.R. 5.86, p<0.01, 95% C.I. 4.81-7.14, and H.R. 1.32, p<0.01, 95% C.I. 1.12-1.55, respectively), intubation (H.R. 2.93, p<0.01, 95% C.I. 2.50-3.45) and health care in public health services (more than twice the risk, p<0.01), were independent factors increasing the risk of death due to COVID-19. Conclusions. The risk of dying at any time during follow-up was especially higher in men, individuals at the older age groups, with chronic kidney disease and people hospitalized in the public health services.
Cell-Mimicking Nanodecoys Protect Lung Cells by Neutralization of SARS-CoV-2 Spike Proteins
Authors: Li Zhenhua , Dinh Phuong-Uyen C. , Popowski Kristen D. , Lutz Halle , Wang Zhenzhen , Zhu Dashuai , Hu Shiqi , Lobo Jason , Cheng Ke
Published: June 2020

Coronavirus disease of 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has grown into a global pandemic, with no specific antiviral treatments or vaccines are yet approved. The viral receptor, angiotensin-converting enzyme 2 (ACE2), has been demonstrated to play an integral role in the pathogenesis of SARS-CoV-2, necessary for host cell viral entry. Inspired by this, we synthesized ACE2 nanodecoys from human lung spheroid cells (LSCs) capable of binding the Spike protein as a potential neutralization agent for SARS-CoV-2. Our results show LSC-nanodecoys has a high affinity and neutralization efficiency to both spike protein and chemically synthesized SARS-CoV-2 mimics. In addition, non-invasive inhalation therapy in mice showed successful delivery of the nanodecoy to the lungs, as well as in-vivo retention of the nanodecoys over 72 hours after a single administration. Furthermore, inhalation of nanodecoy accelerated the clearance of SARS-CoV-2 mimics from the lung and did not cause toxicity.
In silico Drug Repurposing to combat COVID-19 based on Pharmacogenomics of Patient Transcriptomic Data
Authors: Das Shaoli , Camphausen Kevin , Shankavaram Uma
Published: June 2020

The ongoing global pandemic of coronavirus disease 2019 (COVID-19) continues to affect a growing number of populations in different parts of the world. In the current situation, drug repurposing is a viable strategy to combat COVID-19. The drugs targeting the host receptors that interact with SARS-CoV-2 are possible candidates. However, assessment of their effectiveness in COVID-19 patients is necessary before prioritizing them for further study. We attempted to shortlist the candidate drugs using an in-silico approach. First, we analysed two published transcriptomic data sets of COVID-19- and SARS-infected patients compared to healthy individuals to find the key pathways altered after infection. Then, using publicly available drug perturbational data sets in human cell lines from the Broad Institute Connectivity Map (CMAP), we assessed the effects of the approved drugs on the altered pathways. We also used the available pharmacogenomic data sets from the Genomics of Drug Sensitivity in Cancer (GDSC) portal to assess the effects of the altered pathways on resistance or sensitivity to the drugs in human cell lines. Our analysis identified many candidate drugs, some of which are already being investigated for treatment of COVID-19 and can serve as a basis for prioritizing additional viable candidate drugs for COVID-19.
High Tunnel and Grafting Effects on Organic Tomato Plant Growth and Yield in the Subtropics
Authors: Frey Craig J. , Zhao Xin , Brecht Jeffrey K. , Huff Dustin M. , Black Zachary E.
Published: June 2020

Although grower interest in high tunnel tomato (Solanum lycopersicum) production has increased in recent years, systematic high tunnel research conducted in humid, subtropical regions has been limited. The potential of tomato grafting to mitigate biotic and abiotic stresses makes it complementary to high-value production systems in high tunnels. In this 2-year study, grafted vs. nongrafted organic tomato production in high tunnels and open fields was investigated to determine possible synergistic effects of these two technologies. In 2016, high tunnels resulted in a significant increase of total and marketable yields, by 43% and 87%, respectively, over open field production. Grafting also significantly increased total and marketable yields over nongrafted plants by 34% and 42%, respectively. Cultivar effects demonstrated greater benefits with the implementation of high tunnel and grafting technologies for ‘Tribute’ (a beefsteak-type tomato) than for ‘Garden Gem’ (a plum-type tomato), as the increase in marketable yield was 33% greater for ‘Tribute’ in high tunnels and 45% greater for ‘Tribute’ with grafting. In 2017, a delayed effective transplanting date and the lack of high tunnel summer season extension produced results that were generally cultivar specific. While grafting increased the total yield of both cultivars (by 18%), marketable yield was increased by grafting only for ‘Tribute’ in high tunnels (by 42%). Additionally, high tunnels improved marketable yield of ‘Tribute’ by 129% but had no effect on ‘Garden Gem’. This demonstrated the consistent trend of the beefsteak-type tomato benefiting more from the combination of high tunnel and grafting technologies than the plum-type tomato. High tunnels reduced fruit decay and cracking by up to 71% compared with open field production. Stink bug (Pentatomidae) damage had the greatest impact on marketable yields each season, reaching 13% and 34% of total yields in 2016 and 2017, respectively, and was unaffected by high tunnel production or grafting. This study revealed the benefits of integrating high tunnel and grafting technologies for enhancing organic production of fresh-market tomato in the humid subtropics, and demonstrated more research is warranted to establish regional planting dates and further optimize this high-value cropping system.
Efficiency of the stakeholder interaction in the context of ensuring sustainable territorial development
Authors: Smalskys Vainius , Gavkalova Nataliia , Babenko Kristina , Zolenko Alona
Published: June 2020

The strategic approach to sustainable territorial development precisely assesses all regional disparities. Implementing this approach allows considering the interests and requirements of all stakeholders and identifying priority areas for regional development. A detailed analysis of existing regional development strategies and programs confirms the active region interaction with numerous organizations, groups, and individuals. The growing role of stakeholders in shaping regional policy determines the necessity of the research. Proposed conceptual approach will contribute determining the stakeholders’ interaction effectiveness in ensuring sustainable territorial development. Algorithm for analyzing the stakeholders’ interaction effectiveness was worked out based upon critical analysis of the scientific professionals’ main approaches of identifying and comparing the interests of stakeholders’ sectoral and territorial groups in the context of solving the region existing problems. A feature of the proposed measure scheme of the stakeholder interaction efficiency is the synthesis of quantitative and qualitative assessment of the stakeholder interaction effectiveness using the method of expert assessments, statistical analysis, and fuzzy sets. The practical part of the developed approach to determining the effectiveness of stakeholder interaction allowed to assess the level of regional development programs implementation in the Kharkiv region and to identify the synergistic effect of stakeholder interaction. The made conclusions and recommendations regarding the solution of region existing problems have found practical application in predicting scenarios for the territory development.
PARTICIPAÇÃO E AUSÊNCIA FAMILIAR: IMPLICAÇÕES PARA O DESENVOLVIMENTO DE CRIANÇAS E ADOLESCENTES COM NECESSIDADES ESPECIAIS
Authors: Silveira Andressa Da , Alves Bruna Thais Garcez , Elauterio Mariely Piovesan , E Silva Flávia Oliveira , Costa Yasmin Sabrina , De Souza Neila Santini
Published: June 2020

Objetivo: descrever a participação dos familiares no cuidado clínico e acompanhamento escolar de crianças e adolescentes com necessidades especiais (CRIANES) de saúde na perspectiva dos profissionais de saúde e educação da Associação de Pais e Amigos dos Excepcionais (APAE). Método: estudo de abordagem qualitativa, do tipo participativo, onde a produção de dados ocorreu pelo desenvolvimento da dinâmica de criatividade e sensibilidade linha da vida. Participaram da dinâmica 10 profissionais da saúde e da educação da clínica e da escola, onde a produção ocorreu por meio da metáfora de um varal que representava a linha da vida de cada profissional diante da questão geradora de debate. As produções foram frases e desenhos construídos individualmente e socializados em grupo. As enunciações foram áudio gravadas, transcritas e submetidas à análise de discurso na corrente francesa. Resultados: as produções e os discursos enalteceram a importância da participação das famílias em prol do desenvolvimento das habilidades das crianças e adolescentes e que o impacto é positivo inclusive na adesão ao tratamento e cuidados no âmbito domiciliar. Conclusão: os profissionais da saúde e da educação percebem a importância do trabalho que desenvolvem com as CRIANES. Para eles, o processo de desenvolvimento, da aquisição de habilidades e adesão ao tratamento somente serão satisfatórios com esforços coletivos da família, clínica e escola em prol da saúde e educação das CRIANES.
O IMPACTO DA PARTICIPAÇÃO EM PROGRAMAS PET-SAÚDE NA FORMAÇÃO DO FISIOTERAPEUTA NO NORTE DO BRASIL
Authors: Teixeira Renato Da Costa , Norte Raimunda Silvia Gatti
Published: June 2020

Este artigo analisa o processo de reorientação da formação profissional em saúde. Teve como objetivo analisar o impacto da participação em programas PET-Saúde na formação do fisioterapeuta, egressos de uma universidade pública. Utilizou metodologia qualitativa, sendo entrevistados 10 fisioterapeutas que haviam participado do programa. Os resultados demonstraram que os participantes vivenciaram plenamente a prática da atenção à saúde, proporcionando o desenvolvimento de uma visão crítica dos processos de trabalho. Por outro lado, foi constatado fragilidades no que se refere ao que é preconizado pelas Diretrizes Curriculares vigentes para o curso de fisioterapia, demonstrando a necessidade de se repensar o Projeto Político Pedagógico. A participação no programa PET-Saúde ocorreu como uma atividade complementar, não articulada a graduação.
THE EFFECT OF INVESTIGATIVE, INDEPENDENT AUDIT AND DUE PROFESSIONAL CARE AUDITS ON THE EFFECTIVENESS OF THE IMPLEMENTATION OF FRAUD PROCEDURES MODERATED BY SOCIAL PRESSURE IN THE INTERNAL AUDIT DEPARTMENT OF PT. INDOAGUNG MULTIKREASI CERAMIC INDUSTRI & PT. WIJAYA DISTRIBUTION
Authors: Rahmat Dede , Sari Eko Gumaya
Published: June 2020

This research is a study on "The Effect of Investigative Audit, Independent Audit and Due Professional Care Verification Procedures for Implementation Effectiveness Against Fraud which in moderation by Social Pressure". The dependent variable in this study is the Effectiveness of Implementation of Era Fraud (Fraud) Procedures, while the independent variable is the Investigative Audit, Independent Audit and Due Professional Care. Moderating variables using variable Social Pressure. The Internal Audit Department of PT. Indoagung Multikreasi Ceramic Industry. Samples that meet the criteria are as many as 60 respondents. A couple of stages. The first stage is to explore the theory of formulation of research problems and hypotheses. The second stage is the collection of data from the unit of analysis is researched. The Descriptive Test and Reliability Test, the fourth stage of the research hypothesis testing using multiple regression to test the hypothesis either partially or simultaneously. The fifth stage is the Social Pressure testing of the moderating effect, not weaken or diminished the effect of the Audit and Due Professional Care Verification Procedures of the Implementation Effectiveness Against Fraud (Fraud). The significant effect on the effect of the implementation of the procedure is that there is a significant effect on the effectiveness of the procedure. Effectiveness of the Implementation Procedures of Evidence Fraud (Fraud). Simultaneously Investigative Audit Variables, Independent Audit and Due Care Professionals have significant effects on the procedures for Implementation of Evidence Fraud (fraud). Moderation of Social Pressure Able to weaken the influence of Investigative Audit, Independent Audit and Due Professional Care of the Effectiveness of the Implementation Procedures of Evidence Fraud (fraud)
THE EFFECT OF ECONOMIC STRENGTH, GOVERNMENT DEBT, LEVEL OF DEMOCRACY, PUBLIC TRUST, AND LEVEL OF HAPPINESS ON CORRUPTION PERCEPTION
Authors: Susanto Dedy
Published: June 2020

This study aims to analyze the effect of economic strength, government debt, level of democracy, public trust in government, and level of happiness on corruption perception. Data consisting of 113 countries are used to determine the causal relationship between variables that have been collected. Robust Regression statistical test with Method of Moment (MM) estimation is used to analyze the relationship between variables. The test results show that economic strength, level of democracy, public trust, and level of happiness have a significant positive effect on corruption perception, while government debt has no significant effect on corruption perception. It can be concluded that the higher the economic strength, the level of democracy, the public trust, and the level of happiness, the higher the corruption perception in the country. High corruption perception indicates the cleanliness of the country from corruption.
FRAUD AND WHISTLEBLOWING IN THE MANAGEMENT OF STUDENT FUNDS
Authors: Hapsari Aprina Nugrahesthy Sulistya , Supriyono Edi
Published: June 2020

The aim of this study was to find out whether there is the potential for fraud and whistleblowing in the management of student funds as a way to detect fraud in universities. The type of research used in this study was descriptive qualitative research. Data collection was done through interviews, observation, and documentation. This study was conducted at one of universities located in Central Java by describing several variables including fraud, whistleblowing and management of student funds.. The data was analyzed using fraud triangle framework and the fraud scheme based on the ACFE classification. The results of this study show that in the management of student funds there was the potential for fraud, such as misuse of financial statements and corruption. There was indication of fraud, but it did not happen. Potential for whistleblowing was not found because they assume that if fraud occurs it is better to discuss it in a family manner and will not report it.
Pengembangan Bahan Ajar Kimia Berbasis Integrasi Islam-Sains Materi Minyak Bumi Sebagai Implementasi Pendidikan Karakter
Authors: Faeha Ana , Wahid Abdul , Udaibah Wirda
Published: June 2020

Rendahnya hasil belajar peserta didik pada materi hidrolisis khususnya pada level mikroskopik dan proses pembelajaran yang masih menggunakan metode pembelajaran konvensional di MA Uswatun Hasanah, sehingga dilakukan penelitian ini. Model POGIL (Process Oriented Guided Inquiry Learning) bermuatan Multiple Level Representation diharapkan dapat mengetahui tingkat penguasaan konsep dan retensi peserta didik MA Uswatun Hasanah pada materi hidrolisis. Metode: Penelitian ini menggunakan satu sampel untuk memperoleh data penelitian yaitu kelas XI jurusan IPA. Data penelitian diperoleh dengan metode dokumentasi untuk mendapatkan daftar nama-nama peserta didik kelas XI jurusan IPA MA Uswatun Hasanah dan metode tes untuk memperoleh data hasil belajar peserta didik yang diperoleh dari nilai pretest, posttest, dan retest. Hasil penelitian : Penelitian ini menunjukkan bahwa pembelajaran melalui model POGIL bermuatan Multiple Level Representation dapat meningkatkan tingkat penguasaan konsep dan retensi peserta didik kelas XI IPA MA Uswatun Hasanah. Terdapat 30% peserta didik mengalami peningkatan penguasaan konsep kategori tinggi, 40% peserta didik mengalami peningkatan penguasaan konsep kategori sedang, dan 30% mengalami peningkatan penguasaan konsep kategori rendah. Adapun tingkat retensi peserta kelas XI IPA MA Uswatun Hasanah adalah 92,7% yang tergolong tinggi. Berdasarkan hasil penelitian yang telah dilakukan, dapat disimpulkan bahwa Pembelajaran dengan menggunakan model POGIL bermuatan Multiple Level Representation dapat meningkatkan tingkat penguasaan konsep dan retensi peserta didik kelas XI IPA MA Uswatun Hasanah.
Penguasaan Konsep dan Retensi melalui Pogil (Process Oriented Guided Inquiry Learning) Bermuatan Multiple Level Representation
Authors: Khulliyah Khulliyah , Fadlan Andi
Published: June 2020

Rendahnya hasil belajar peserta didik pada materi hidrolisis khususnya pada level mikroskopik dan proses pembelajaran yang masih menggunakan metode pembelajaran konvesional di MA Uswatun Hasanah. Melalui model POGIL (Process Oriented Guided Inquiry Learning) bermuatan Multiple Level Representation diharapkan dapat mengetahui tingkat penguasaan konsep dan retensi peserta didik MA Uswatun Hasanah pada materi hidrolis. Data penelitian diperoleh dengan metode dokumentasi untuk mendapatkan daftar nama-nama peserta didik kelas XI jurusan IPA MA Uswatun Hasanah dan metode tes untuk memperoleh data hasil belajar peserta didik yang diperoleh dari nilai pre-test, post-test, dan retest. Penelitian ini menunjukkan bahwa pembelajaran melalui model POGIL bermuatan Multiple Level Representation dapat meningkatkan tingkat penguasaan konsep dan retensi peserta didik kelas XI IPA MA Uswatun Hasanah. Terdapat 30% peserta didik mengalami peningkatan penguasaan konsep kategori tinggi, 40% pada kategori sedang, dan 30% pada kategori rendah. Adapun tingkat retensi peserta didik adalah 92,7% yang tergolong tinggi. 
Development status and application of neuronavigation system
Authors: Zheng Qi , Liu Chaoyue , Pan Qiuling , Chang Jincai , Cui Jianzhong
Published: June 2020

The neuronavigation system is a combination of navigation technology and neurosurgery. It can be used to assist in neurosurgery through three-dimensional reconstruction of medical image data, extraction of lesions, optimal surgical path planning, tracking and positioning of surgical instruments, and real-time intraoperative display. Accurate and maximal treatment of lesions, while effectively avoiding secondary injuries to patients during surgery. Therefore, the development and application of neuronavigation systems are reviewed.
Heteroannulation Routes to Bioactive Pyrazolooxazines
Authors: Dawood Kamal M. , Farghaly Thoraya A. , Raslan Mohamed A.
Published: June 2020

Pyrazolo-oxazine fused systems are interesting classes of heterocyclic compounds exhibiting pronounced biological applications such as anticancer, antitubercular, anti-inflammatory, antibacterial and antifungal activities as well as inhibiting COX-1 and COX-2 enzymes. Depending on the distribution position of the heteroatoms (N and O), there are fourteen different systems of pyrazolo-oxazine. Nine of them were biologically abundant in literature, for example, pyrazolo[3,4-e][1,3]oxazines are used as analogs of antibiotics Formycin, Formycin B, Oxoformycin B. This review article summarizes the concerted efforts expended on most of the synthetic routes to the various types of pyrazolo-oxazines in the literature until the first quarter of 2020. The reactions of pyrazolo-oxazines with various reagents are also outlined.
QSAR Studies of Sulfonamide Hydroxamates Derivatives as MMP-2 Inhibitors Topomer CoMFA and Molecular Docking
Authors: Tong Jian-Bo , Yi Feng , Luo Ding , Wang Tian-Hao
Published: June 2020

Background:

In recent years, cancer has become the main cause of death and it is a serious
threat to human health, so the development of new, selective and safe anticancer drugs is still
the focus of medical research. Matrix metalloproteinases-2 (MMP-2) has been determined to play an
important role in the regulation of tumor angiogenesis, which is closely related to the development
of the tumor. Therefore, MMP-2 is considered as a promising target for tumor therapy. In this study,
Tomper comparative molecular field analysis (Topomer CoMFA) and molecular docking were used
to investigate the important role of sulfonamide hydroxamate derivatives, an inhibitor of MMP-2, in
the inhibition of angiogenesis.

Methods:

Quantitative structure active relationship (QSAR) models of 35 sulfonamide hydroxamate
derivatives with inhibitory MMPs were developed. The quantitative structure-activity relationship
(QSAR) model was built by using Topomer comparative molecular field analysis (Topomer CoMFA)
technique.

Results and Conclusion:

The results show that the cross-validated q2
value of the Topomer CoMFA
model is 0.881 and the non-cross-validated r2
value is 0.967. The results show that the model is
reasonable and reliable, and has good prediction ability. Molecular docking studies were used to
find the actual conformations of chemicals in active sites of cancer protease, as well as the binding
mode pattern to the binding site in MMP-2. The information provided by the 3D-QSAR model and
molecular docking may lead to a better understanding of the structural requirements of 35 sulfonamide
hydroxamate derivatives and help to design potential anti-cancer protease inhibitor molecules.

Conclusion:

Thirty-five analogs were used in the 3D-QSAR study. Topomer CoMFA 3D-QSAR
method was used to build the model, and the model was well predicted and statistically validated.
The results of 3D-QSAR and molecular docking analysis provide theoretical guidance for the synthesis
of new MMP-2 inhibitors.
In vitro Effect of Chlorquine and Picroliv on Plasmodium Berghei Induced Alterations in the Activity of Adenosine Triphosphatase, Aryl Hyrocarbon Hydroxylase Enzymes and Malondialdehyde in Spleen Explant Culture
Authors: Trivedi Anchal , Misra Aparna , Sarkar Esha , Balapure Anil K.
Published: June 2020

Background:

In recent years, great progress has been made in reducing the high level of
malaria suffering worldwide. There is a great need to evaluate drug resistance reversers and consider
new medicines against malaria. There are many approaches to the development of antimalarial
drugs. Specific concerns must be taken into account in these approaches, in particular the requirement
for inexpensive and simple new therapies and the need to limit drug discovery expenses. Important
ongoing efforts are the optimisation of treatment with available medications, including the
use of combination therapy, the production of analogs of known agents and the identification of natural
products, the use of compounds originally developed against other diseases, the assessment of
overcoming drug resistance and the consideration of new therapeutic targets. Liver and spleen are
the important organs which are directly associated with malarial complications.

Aim:

An analysis of the Activity of Adenosine Triphosphatase, Aryl Hyrocarbon Hydroxylase Enzymes
and Malondialdehyde in spleen Explant Culture.

Objective:

To determine in vitro effectof Chlorquine and Picroliv on Plasmodium Berghei induced
alterations in the Activity of Adenosine Triphosphatase, Aryl Hyrocarbon Hydroxylase Enzymes
and Malondialdehyde in spleen Explant Culture.

Result:

Splenomegalyis isone of the three main diagnostic parameters of malaria infection besides
fever and anaemia. Many enzymes present in the liver and spleen may also be altered or liberated
under different pathological conditions. Enzymes (ATPase, ALP&GST) and the level of protein,
Malondialdehyde (MDA) content was found to increase in the liver and spleen explants during
malarial infection. In the liver and spleen derived from parasitized CQ treated animals, the activity
of all the above enzymes (ATPase, ALP&GST) and the level of protein & MDA of liver/spleen reversed
towards the normal for all the 4 or 3 days of incubations. Picroliv efficacy decreased with the
increment of parasitaemia and at 60% parasitaemia.

Conclusion:

Alkalinephosphatase (ALP) was found to increase with increasing parasitaemia. After
the addition of Picroliv to the medium, a decrement in the activity was observed up to day 4 of culture.
A similar positive effect of Picroliv was observed on the ATPase and ALP activity of spleen
explants. DNA and protein contents also increased in the parasitized liver cultured in the presence
of picroliv. On the contrary, in the spleen explants DNA, protein and MDA content were found to
decrease after Picroliv supplementation to the culture medium.
Some Methods for Constructing Infinite Families of Quasi-Strongly Regular Graphs
Authors: Shirdel Gholam Hassan , Asgari Adel
Published: June 2020

:

In this article, we examined some method of constructing infinite families of semi-strongly regular graphs, Also we obtained a necessary condition for the composition of several graphs to be semi-strongly regular graphs, and using
it, we have constructed some infinite families of semi-strongly regular graphs, Also by using the Cartesian product of two
graphs, we have constructed some infinite families of semi-strongly regular graphs.
illocutionary acts of the characters in wonder A novel by R.J. Palacio
Authors: Wahyudiantari Ni Wayan Prami , Budiarsa Made , Yadnya Ida Bagus Putra , Satyawati Made Sri
Published: June 2020

This research discusses the use of illocutionary acts uttered by the characters in Wonder a novel by R.J. Palacio. It explores how the acts of illocutionary are conveyed by the characters in the whole novel. The purpose of this study is to find the type of illocutionary acts uttered by the main characters, the intended meaning of utterances, and the character’s purposes in using such assertive. This research applies the pragmatics theory about speech acts to analyze the use of illocutionary acts in conversations. This study is qualitative research and it uses document as the source of the data that is Wonder a novel by R.J. Palacio. The result of this study shows that there are four types of illocutionary uttered by the characters. The types of illocutionary acts are assertive, commissive, directive, and expressive. Those utterances have the intended meanings that are influenced by the context of the situation in every phenomenon.
Abdominal Sepsis. Some Genetic-Molecular Mechanisms of Its Occurrence
Authors: Kavyn Vasyl
Published: June 2020

Sepsis is a dangerous pathology which is characterized by a high mortality and morbidity in the whole world. Among varieties of sepsis an abdominal sepsis takes the second position. A huge number of scientific investigations, dedicated to sepsis, were done and are being done now. The search for new pathophysiological links of sepsis is ongoing. Studies show that more and more scientists pay attention to the status of genes polymorphism and their influence on the molecular mechanisms of the course of abdominal sepsis, which can help to decide this complex medical problem.
Pengembangan buku panduan pembelajaran taman lalu lintas di taman kanak-kanak
Authors: Cholimah Nur , Budi Maryatun Ika , Christianti Martha , Sapti Cahyaningrum Eka
Published: June 2020

Pengenalan berlalu lintas yang baik sebaiknya ditanamkan sejak usia dini, sehingga lambat laun kegiatan tersebut kan menjadi budaya yang melekat sampai dewasa. Kajian ini dilakukan untuk mengembangkan buku panduan lalu lintas yang akan digunakan untuk pembelajaran di Taman Kanak-kanak. Metode penelitian yang digunakan adalah Research & Development. Pengumpulan data menggunakan tes, observasi dan dokumentasi, yang dianalisas secara kuantitatif dan kualitatif. Responden kajian  ini berjumlah 10 sekolah. Hasil penelitian kuantitatif menunujukan hasil: 1) Kualitas Penyajian 86%, 2) Narasi Bahasa 96%, 3) Kejelasan Buku Panduan 90%, dan 4) Materi 90%. Sementara hasil kualitatif menujukkan bahwa perlu perbaikan dalam hal:  (1) Ukuran buku (2) Jumlah Gambar, (3) Tata Lay Out (5) Penulisan kata, (6) Penyesuaian RPP sesuai model Lalu lintas Indonesia, (7)Materi disesuaikan Kurikulum K13, dan (8) Alur Skenario. Buku Panduan ini layak diterapkan di sekolah agar penamaman disiplin melalui taman lalu lintas dapat dibiasakan sejak dini.
Mapping Evidence on Community-Based Clinical Education Models for Undergraduate Physiotherapy Students: Protocol for a Scoping Review
Authors: Chemane Nomzamo Charity Thobekile , Chetty Verusia , Cobbing Saul
Published: June 2020

Background

Community-based clinical training has been advocated as an excellent approach to transformation in clinical education. Clinical education for undergraduate physiotherapy students is a hands-on practical experience that aims to provide a student with the skills necessary to enable them to be fit to practice independently. However, in many countries, including South Africa, this training has been conducted only in large urban academic hospitals. Such hospitals are not a true reflection of the environment that these students will most likely be facing as practicing health care professionals.

Objective

The objective of this scoping review is to map out existing evidence on community-based clinical education models for undergraduate physiotherapy students globally.

Methods

A systematic scoping review will be based on the 2005 Arksey and O’Malley framework. Studies involving students and stakeholders in clinical education will be included. This review will not be limited by time of publication. An electronic search of relevant literature, including peer-reviewed primary studies and grey literature, will be conducted from the PubMed, Google Scholar, Medline, CINAHL, and Cochrane Library databases. The search strategy will include keywords such as “education,” “physiotherapy,” “undergraduate,” “community-based,” “training,” “decentralized,” and “distributed.” Boolean logic will be used for each search string. Two independent reviewers will conduct screening of titles, abstracts, and full text before extracting articles. A predesigned data-charting table will supplement the extraction of data. Version 12 NVIVO software will aide in the thematic analysis of data.

Results

Data collection will commence after publication of this protocol, and the results are expected to be obtained in the following 5 months.

Conclusions

The evidence obtained from the extracted data is expected to assist in the development of a model of community-based clinical education for undergraduate physiotherapy students in South Africa, and serve as a basis for future research. The discussion of this evidence will be guided by the research question utilizing a critical narrative approach to explore emerging themes. The enablers and barriers identified from the reviewed studies can guide the development of a community-based clinical education model.

International Registered Report Identifier (IRRID)

PRR1-10.2196/19039
Mental Health Practitioners’ Immediate Practical Response During the COVID-19 Pandemic: Observational Questionnaire Study (Preprint)
Authors: Reilly Shannon E , Zane Katherine L , McCuddy William T , Soulliard Zachary A , Scarisbrick David M , Miller Liv E , Mahoney III James J
Published: June 2020

BACKGROUND

The COVID-19 pandemic has been associated with increased psychological distress, signaling the need for increased mental health services in the context of stay-at-home policies.

OBJECTIVE

This study aims to characterize how mental health practitioners have changed their practices during the pandemic. The authors hypothesize that mental health practitioners would increase tele–mental health services and that certain provider types would be better able to adapt to tele–mental health than others.

METHODS

The study surveyed 903 practitioners, primarily psychologists/doctoral-level (Psych/DL) providers, social workers/master’s-level (SW/ML) providers, and neuropsychologists employed in academic medical centers or private practices. Differences among providers were examined using Bonferroni-adjusted chi-square tests and one-way Bonferroni-adjusted analyses of covariance.

RESULTS

The majority of the 903 mental health practitioners surveyed rapidly adjusted their practices, predominantly by shifting to tele–mental health appointments (n=729, 80.82%). Whereas 80.44% (n=625) were not using tele–mental health in December 2019, only 22.07% (n=188) were not by late March or early April 2020. Only 2.11% (n=19) reported no COVID-19–related practice adjustments. Two-thirds (596/888, 67.10%) reported providing additional therapeutic services specifically to treat COVID-19–related concerns. Neuropsychologists were less likely and Psych/DL providers and SW/ML providers were more likely than expected to transition to tele–mental health (P<.001). Trainees saw fewer patients (P=.01) and worked remotely more than licensed practitioners (P=.03). Despite lower rates of information technology service access (P<.001), private practice providers reported less difficulty implementing tele–mental health than providers in other settings (P<.001). Overall, the majority (530/889, 59.62%) were interested in continuing to provide tele–mental health services in the future.

CONCLUSIONS

The vast majority of mental health providers in this study made practice adjustments in response to COVID-19, predominantly by rapidly transitioning to tele–mental health services. Although the majority reported providing additional therapeutic services specifically to treat COVID-19–related concerns, only a small subset endorsed offering such services to medical providers. This has implications for future practical directions, as frontline workers may begin to seek mental health treatment related to the pandemic. Despite differences in tele–mental health uptake based on provider characteristics, the majority were interested in continuing to provide such services in the future. This may help to expand clinical services to those in need via tele–mental health beyond the COVID-19 pandemic.
Tracking what People Are Actively Researching or Planning Amidst COVID-19: Development of a Public Google Ads Data Set (Preprint)
Authors: AlTamime Reham , Weber Ingmar
Published: June 2020

BACKGROUND

The spread of the COVID-19 has created a substantial impact on economies, governments, businesses, and most importantly, on people’s health. In order to bring the spread of the COVID-19 under control, strict lockdowns measures have been implemented across the globe. These lockdown measures have prompted a spate of panic buying and increase in demand for hygiene products and other grocery items.

OBJECTIVE

In this paper, we describe a panic buying Google Ads data set that we are making available to the research community via our COVID-19 GitHub repository.

METHODS

We started this ongoing data collection on March 28, 2020, leveraging developer tools’ network requests to retrieve Google Ads’ data. We have identified a list of items related and unrelated to panic buying. Then, we have captured these items as targeting criteria under what people are actively researching or planning on Google Ads. Google Ads’ data has been filtered by additional targeting criteria such as countries, gender, and parental status.

RESULTS

Since the inception of our collection, we have actively maintained and updated our GitHub repository on a monthly basis. In total, we have published over 1,827 data points. This paper also presents basic statistics that reveals variations in Google Ads data across countries, gender, and parental status.

CONCLUSIONS

We hope that this Google Ads data set can contribute to study changes in behaviors and attitudes during the Coronavirus outbreak. Moreover, we hope that this data set can help in understanding public fear and panic during this unprecedented time.
Participation Effectiveness of Citizen Participatory Budgeting: The Case of Yanjin County in China
Authors: Lin Muhua , Chen Kaiping
Published: June 2020

Citizen participatory budgeting (CPB) is a mechanism to enhance governance, particularly regarding accountability and responsiveness. The growing literature on the topic, however, has not addressed the participation effectiveness of CPB in developing countries. Drawing mainly from first-hand data, this study examines the participation effectiveness of the recent CPB reform in Yanjin, a poor county in southwestern China. It is found that with a well-designed participatory mechanism, citizen representatives of the Yanjin County have effectively participated in public budgeting. This study, therefore, has important implications for other localities in China as well as other developing countries that are interested in using CPB to improve local governance.
Pathways to Citizen Participation: Participatory Budgeting Policy Choice by Local Governments
Authors: Krueger Skip , Park HyungGun
Published: June 2020

The existing literature on participatory budgeting - as one means of citizen participation in local governance - tends to focus on how to stimulate citizen participation in the budget process, and primarily aims to descriptively explain the magnitude of participation or the adoption of specific policy approaches. We investigate participatory budgeting from an institutional perspective and empirically evaluate the choices that local governments make in adopting a specific set of rules for including citizens in the budget process. We suggest that the choice of the type of participatory budgeting policy is predicated on the partisanship of policymakers, the administrative capacity of local government, and citizen's experience with other forms of direct democracy. To test these hypotheses, we collect information on 224 local governments in South Korea from 2004 to 2013. For each city, we identify the type of participatory budgeting policy they adopt and evaluate that choice in an empirical model. The results provide evidence that the partisanship of local policymakers and the administrative capacity of the local government are associated with different choices about the inclusion of citizens in the budget process.
Participatory Budgeting in the Philippines
Authors: Franklin Aimee L. , Ebdon Carol
Published: June 2020

Participatory budgeting has been adopted and adapted by governments around the world. Existing literature points to a variety of desired outcomes from these efforts, but does not clearly distinguish the impacts on individuals, groups, and society. This study uses the case of the Philippines to explore the differences in impacts of participatory budgeting within and across the three levels. Reforms in the Philippines were similar to efforts in other countries, but there were adaptations, including a national mandate for the decentralization of participatory budgeting to local governments and the required representation of civil society organizations in local resource allocation processes.

Some gains in individual education and efficacy, representation of marginalized groups and social justice, and government accountability were seen in the Philippines, but they seem to be idiosyncratic to the local context. Civil society and democratic legitimacy advances, though, were weaker, at least partly due to challenges in involving third-party intermediaries in the process, and continued issues with elitism and corruption. Like other participatory budgeting cases, the outcomes have not been uniform, and transitions in national leadership hinder institutionalization.
OBRAZOVANJE ROMSKE NACIONALNE MANJINE I STRATEGIJA ZA SOCIJALNO UKLJUČIVANJE ROMA U SRBIJI
Authors: Raduski Nada
Published: June 2020

Romi su od svih nacionalnih manjina u Srbiji u najnepovoljnijem položaju po svim socijalnim, demografskim, ekonomskim, kulturnim i drugim pokazateljima. Mada je u prethodnoj deceniji određenim merama, politikama i strategijama dosta urađeno na unapređenju položaja Roma, oni su na najnižoj lestvici društvene hijerarhije, suočeni sa brojnim negativnim stereotipima i predrasudama, velikom etničkom distancom, neobrazovanošću, nezaposlenošću i siromaštvom. Obrazovanje, kao jedno od najaktuelnijih pitanja, ključ je za socijalnu promociju Roma, za izlazak iz začaranog kruga siromaštva i poboljšanje njihovog materijalnog i sociokulturnog položaja. U radu se na osnovu zvaničnih podataka popisa stanovništva sagledava obrazovna struktura Roma i ogroman jaz koji postoji u odnosu na opštu populaciju, kao i međunarodni i nacionalni pravni okvir u oblasti obrazovanja pripadnika romske nacionalne manjine. Posebno se razmatra Strategija za socijalno uključivanje Roma i Romkinja u Republici Srbiji za period od 2016. do 2025.godine, a u okviru nje obrazovanje kao jedna od pet oblasti ključnih za unapređenje ekonomskog položaja, socijalnu mobilnost i punu integrisanost Roma u sve sfere društvenog života.