bluuebunny/crossref_metadata_2025 huggingface dataset:
DISABILITY OF MOTIVATION-SUMMER SPHERE IN PATIENTS WITH DIABETES MELLITUS
Authors: Burovska Irina
Published: February 2020

Psychological researches that reveal the essence of disorders of the motivational and semantic sphere in patients with diabetes mellitus are considered. Understanding the disease as a complex of somatic and psychological dysfunctions gives the opportunity to develop effective methods of support for chronically ill persons, to reveal the essence and to analyze the disorders of the motivational and semantic sphere in this group of persons. Particular attention is paid to the study of the aspect of intrinsic motivation, as extrinsic motivation is already present in the form of a disease with which one must learn to live. The stages of intrinsic motivation in patients with diabetes mellitus are examined in detail, the disorders that occur on each of them are identified and analyzed. The peculiarities of patients' motivational and semantic sphere as one of the most important personality substructures have been determined. The semantic sphere of personality and the basis of personal meaning (by D. O. Leontiev) are considered. The main directions of the study of diabetes as a psychosomatic disorder are described and analyzed, which makes it possible to search for harmonious adaptation of the patient in society and individual motives for leaving the disease. The analysis of the dynamics of the motivational – semantic sphere in patients with diabetes mellitus was carried out within the framework of scientific search of psychodynamic researchers, which gives an opportunity to understand the disease as a complex of somatic and psychological dysfunctions. Possibilities of positive psychotherapy and its role in the motivational and semantic sphere for patients with diabetes mellitus are considered. The focus of our view on psychological disorders is related to illness and the important role of physicality in blocking the semantic aspect in this category of patients. The prospects for further exploration and the need for comprehensive research in this problem area.
PSYCHOLOGICAL DISPOSITIONS THAT REGULATES DECISION-MAKING PROCESS OF DRUG ADDICTS
Authors: Darvishov Nariman
Published: February 2020

The article is devoted to the research of dispositions that regulates decision-making process of substance addicts. Decision making process is often marked as one of a key links, that leads to addiction and then became impaired of its consequences – behavior altering and comorbid disorders of cognitive functioning. Defining this premorbid and comorbid specific could be helpful with understanding of addiction phenomena as whole. Comparing two groups by Mann-Whitney statistic criteria — a group of substance addicts and group of non-addicts have shown a list of specific tendencies in the manifestation of personal dispositions that confirmed as decision-making moderators.

For the group of addicts is more inherently to have a higher degree of hypervigilance and intuitive ability, than for a control group, less inherently to have a higher level of vigilance, tolerance for ambiguity, as well as high intolerance for ambiguity. This points to tendency to make decisions in more impulsive way, and make more biased processes of rational regulation, especially in stress-rich environment. As for the perception of the temporal perspective, the orientation towards the hedonistic "here and now" before future consequences is more appropriate, combining with enhanced negative-past perception. Therefore, addicts time perception is another important axis of decision-making process analysis.

In general, discovered features in individual dispositions of addicts, could point to the style-specific signature of decision-making process that can be localized within the predominance of implicit, rapid, intuitive processes, mostly impulsive in the degree of self-control and focused on the present, instead of taking long-term perspectives and conscience into the process. Such features must be taken into account in further rehabilitation program development.
Method of molecular docking in the design of new progesterone analogues
Authors: Petrosyan Mariya A. , Belinskaia Daria A. , Taborskaia Kseniia I. , Shabanov Petr D.
Published: February 2020

The aim of this study is to carry out the molecular docking of gestagenic preparations and structurally related compounds to the isoform A of human progesterone receptor and to assess the applicability of this method for the active progestins search. Docking was done (using Autodock 4.2) of progesterone and 13 compounds with different gestagenic/antigestagenic activity (megestrol acetate; (3)-3-Hydroxy-6-methyl-20-oxopregna-4,6-dien-17-yl acetate (AMOL); Medroxyprogesterone-17-acetate; Levonorgestrel; Dydrogesterone; RU-486; Ulipristal acetate; (3)-17-Acetoxy-6-methyl-20-oxopregna-4,6-dien-3-yl butyrate; 16,17-Cyclohexanoprogesterone; 6-Methyl-16,17-cyclohexanoprogesterone; Proligestone; 16,17-Cyclopentanoprogesterone; 16,17-Cyclohex-3-enoprogesterone). Calculations of theoretical dissociation constants (Kd) of ligand-progesterone receptor complexes showed that it is possible to evaluate the probability of activity of a candidate compound using the Autodock 4.2 program, but it requires caution, taking into account the lack of the link between Kd and gestagen activity. In addition, the method allows to identify compounds that change the position of amino acid residues in the ligand-binding domain of PR-A after binding (that is possibly have a different mechanism of action), as well as substances that do not interact with the agonistic form of the receptor due to other causes.
Nootropic effect of combined application of means from Baikal seal fat and cortexin at cerebral ischemia
Authors: Sangadieva Tatyana I. , Gulyaev Sergey M. , Lamazhapova Galina P.
Published: February 2020

In the present study, influence of the complex use of concentrate of polyunsaturated fatty acid (PUFA) from a fat of Baikal seal and cortexin on cognitive functions in rats with cerebral ischemia was evaluated. Cognitive impairments are early signs of cerebrovascular insufficiency, which are based on the development of pathobiochemical reactions that cause damage to the lipid and protein structures of cell membranes. It has been suggested that the administration of PUFA and cortexin will have a nootropic effect due to the synergy of their actions. The aim of the study was to determine the effect of PUFA and Cortexin on cognitive function in rats with cerebral ischemia. The study was performed on Wistar rats of both sexes. A model of cerebral ischemia was reproduced by occlusion of the left common carotid artery under ether anesthesia. Animals received PUFA (20 mg/kg) intragastrically once day for 14 days before surgery and for the next 10 days after in combination with administration of cortexin (4 mg/kg, i.p). For a comparative evaluation of the therapeutic efficacy of the complex use of PUFA and cortexin, three groups of animals were used: piracetam and monotherapy with PUFA, and Cortexin. Behavioral activity and cognitive functions in rats were determined using the methods: open field, elevated plus maze, Morris water maze. It has been established that combined use of PUFA and Cortexin stimulated locomotor and exploratory activity, reduced anxiety in animals and had a more effective nootropic effect as compared with monotherapy.
Definición de obesidad: más allá del índice de masa corporal
Authors: Gutiérrez Cortez Edgar Agustín , Goicochea Ríos Evelyn del Socorro , Linares Reyes Edgardo
Published: February 2020

La obesidad es uno de los principales problemas de salud pública contemporánea, se ha asociado en su génesis a variaciones psicosociales y del comportamiento, al mismo tiempo la obesidad se relaciona a diversas enfermedades no infecciosas como son diabetes mellitus tipo 2 (DM2), hipertensión arterial (HTA), alteraciones del sistema musculoesquelético y diversas neoplasias. Tradicionalmente se ha evaluado y clasificado la obesidad de acuerdo al índice de masa corporal (IMC), sin embargo, esta evaluación es inespecífica porque no discrimina la composición corporal, por lo que actualmente se plantea definir a la obesidad en función de la resistencia del cuerpo al paso de una corriente eléctrica alterna de baja intensidad, la impedancia eléctrica.
Embarazo ectópico ovárico
Authors: Atalaya Taboada Eliana Rocío , Goicochea Ríos Evelyn del Socorro
Published: February 2020

El embarazo ectópico es una patología potencialmente mortal que ocurre en 1 – 2 % de todos los embarazos. El sitio de implantación ectópica más frecuente es la trompa de Falopio, menos del 10 % se implanta en cuello uterino, ovario, miometrio, porción distal de la trompa, cavidad abdominal o dentro de la cicatriz de cesárea. Cuando la presentación se desarrolla en ovario representa el 3 % de todos los embarazos ectópicos, sin embargo, se ha encontrado aumento de su incidencia a nivel mundial. Generalmente se presentan con sangrado vaginal, dolor abdominal y datos de shock. El presente es un caso que acude al servicio de medicina con sintomatología poco específica a la que posteriormente se le realiza ecografía y prueba de embarazo con resultados positivos para la sospecha diagnostica. Se le practica laparotomía de emergencia donde se evidencia restos trofoblásticos en ovario izquierdo y hemoperitoneo. El reporte de patología informó la presencia de restos trofoblásticos del primer trimestre, lo que confirmó la sospecha diagnostica.
Amalgam and Composite Use among Dentists and Dental Interns in Saudi Arabia
Authors: Al-Safadi Rahaf , Radwan Fatimah , Al-Momin Leenah , Bakhsh Raghad , Slais Sarah , Al-Abbad Azhar , Al-Zawad Camelliea , Shamrookh Zahra , Al-Sultan Furat , Al-Dajan Huda i , Al-Muhana Zahra
Published: February 2020

Aim: The aim of this study was to detect the use of amalgam versus resin composite restorations placed in permanent posterior vital teeth among dentists practicing in Saudi Arabia and dental interns training in Saudi Arabia.

Materials and Methods: 318 patients aged ≥ 8 years were randomly selected and clinically examined for amalgam and resin composite restorations placed in permanent posterior vital teeth by dentists and by dental interns in Saudi Arabia. The restorations were placed in teeth preparations Class I and Class II. Also, bitewing and or periapical radiographs were used to define the depth of the cavity. The data obtained were documented in a patient examination form then statistically analyzed using Chi-Square Test or Fisher-Freeman-Halton Test and Spearman’s Correlation Coefficient.

Results: Composite was the predominant kind of restoration placed by dental interns, and dentists placed more composite restorations than amalgam ones. There was an insignificant relationship between the kind of restoration placed by dental interns (amalgam, composite) and the tooth type (maxillary / mandibular premolar, maxillary / mandibular molar), the class of tooth preparation, the cavity depth, the age of the patient, and the gender of the patient p> 0.05. However, there was a significant relationship between the kind of restoration placed by dentists (amalgam, composite) and the cavity depth p < 0.05. Also, dentists placed more composite restorations in maxillary first premolars and in young patients 8-29 years, while they placed more amalgam restorations in mandibular second molars and in older patients 41-50 years p < 0.05. There was an insignificant relationship between the kind of restoration placed by dentists (amalgam, composite) and the class of cavity preparation and the gender of the patient p > 0.05.

Conclusion: Both dentists and dental interns used composite restorative material more than amalgam, but dentists placed more amalgam restorations than dental interns. Dental interns mainly used composite.

Keywords: Amalgam, Composite, Class, Dentist, Depth, Intern, Type.
MECHANISMS OF DEVELOPMENT, OPPORTUNITIES FOR DIAGNOSTICS, TREATMENT, AND PREVENTION OF ALLERGIC RESPONSES TO DRUGS
Authors: Bulgakova V. A. , Eliseeva T. I. , Balabolkin I. I. , Smirnov I. E.
Published: February 2020

Drug allergy includes a wide range of immunological hypersensibility responses with various pathogenesis mechanisms and clinical manifestations. This is a serious type of adverse responses to drugs, which not only affects the quality of life of patients, complicates the treatment of the underlying disease, but in some cases is a potentially life-threatening pathological condition. Given the polymorphic symptoms of drug allergy, its diagnosis is often very difficult. The diagnosis is based on a thorough clinical examination of patients, in some cases, a special allergological examination may be required using in vitro and in vivo tests. An effective strategy for treating drug allergy is to prevent or block the action of a causally important drug. In the presence of alternative preparations, drugs that may cause allergies in a particular patient should be replaced with drugs with a fundamentally different chemical structure. When choosing alternative medications, possible cross-reactivity that occurs among drugs should be considered. Additional therapy in the management of patients with drug hypersensibility responses may include systemic and local corticosteroids, systemic antihistamines. In the case of anaphylaxis, the starting drug of choice is adrenaline. If in the presence of drug allergy to a certain preparation, it is not possible to find an adequate alternative and it is not possible to cancel this type of treatment, then the possibility of carrying out specific immunotherapy with this drug to induce tolerance to a causative drug may be considered.
OPTIMIZATION OF TREATMENT TACTICS FOR ACUTE VIRAL GASTROENTERITIS IN IN-PATIENT CHILDREN
Authors: Maltseva Yulia V. , Kuznetsova T. A.
Published: February 2020

Acute intestinal infections (ACI) being a common form of pathology in children, 50-80% of cases are due to viral agents with a predominance of rotavirus. Patients Over a two-year period, 2556 children aged from 3 months and up to 18 years old were treated in the Department of acute intestinal infections. Two groups of children with viral intestinal infections without extraintestinal bacterial foci were selected. The main group consisted of 259 children who received diet therapy, oral rehydration (ORR) and, according to indications, infusion therapy (IT). 248 children included in the comparison group (CG) received ORP, nitrofurans, antibacterial drugs, enterosorbents, enzymes, probiotics, and, according to indications, IT. Results. In no case did the children of OG receive antibacterial drugs; Compliance with parents allowed IT to be minimized to 17.4% of cases (45 children). In CG, in 74.2% of cases (184 children), patients, in addition to nitrofurans, received III generation cephalosporins, in 81.9% of cases - IT, all children received probiotics, enzymes as symptomatic therapy. Following the recommendations of WHO and ESPGHAN allows avoiding polypharmacy and reduce the economic costs of treating in-patient children with viral gastroenteritis by 3.3 times.
EFFICACY OF DRUG THERAPY OF CHRONIC HEART FAILURE IN YOUNG CHILDREN WITH DILATED CARDIOMYOPATHY
Authors: Zharova O. P. , Basargina Elena N. , Fisenko A. P. , Gandaeva L. A. , Derevnina Yu. V.
Published: February 2020

Dilated cardiomyopathy in children is a very serious disorder with a poor outcome. However, clinical practice has shown that young children have a higher capability to recover cardiac function, which requires an active approach to the prescription of drug therapy. Currently, the combined therapy of chronic heart failure, including ACE inhibitors, beta-blockers, aldosterone antagonists, diuretics, demonstrates high efficiency in reducing the severity of heart failure symptoms, and in improving or stabilizing laboratory and instrumental parameters. Early and adequate administration of drug therapy can improve the prognosis of the disease and prevent an adverse outcome.
ULTRASONIC CHARACTERISTICS OF THE STRUCTURE OF THE LIVER CAPSULE IN HEALTHY CHILDREN OF DIFFERENT AGES
Authors: Khrolenko P. V. , Dvoryakovsky I. V. , Dyakonova E. Yu. , Surkov A. N.
Published: February 2020

Ultrasound examination (ultrasound) takes the first place first among visual methods for analyzing the state of the liver parenchyma. Despite the improvement of ultrasound technology, it does not provide the necessary diagnostic accuracy in determining the stages of liver fibrosis. In this regard, it is necessary to search for additional diagnostic criteria to judge the state of the liver tissue and its superficial structures, primarily liver capsules.Materials and methods: the state of the liver capsule was assessed in 73 children of four age groups (2-18 years) without pathological changes in the hepatobiliary system, which were performed by ultrasound of the abdominal organs during preventive examinations. The structure of the capsule of the liver and visceral peritoneum was evaluated. Results. Direct dependence of the thickness of the liver capsule on the age of children was established (rs = 0.577, p = 0.0000). The capsule and visceral peritoneum represented a single and even echogenic structure (95.9%). Stratification of the leaves was detected in 8 children. A change in the shape of the edge of the right lobe of the liver was observed in 4 children. An increase in the severity of subcapsular blood flow in the liver was not detected in any healthy child.
DISORDERS OF SKIN MICROBIOTA AND FORMATION OF ATOPIC DERMATITIS IN CHILDREN
Authors: Smirnova Galina I. , Korsunsky A. A.
Published: February 2020

The review presents the special significance of changes in the intestinal and skin microbiota in the formation of atopic dermatitis (AD) in children. AD is considered as a form of allergic pathology directly related to the state and quality of the microbiota of a growing organism. The microbiota of the skin of patients with AD is characterized by a small species diversity of bacteria; a decrease in the number of actinomycetes and proteobacteria; increased colonization of various types of staphylococci (S. aureus, S. epidermidis, S. haemolyticus, etc). The relationship between the rate of development of AD and violations of the microbiota of the skin in children is shown. The necessity of maintaining high biodiversity of the microbiota of a growing organism as a strategy for optimizing the microecology of children through the use of adaptive probiotics in a healthy microenvironment is substantiated. The restoration of the barrier function of the skin and the normalization of the composition and quality of the intestinal microbiota are determined as the most important task of the general concept of the treatment of AD, where new dermatological cosmetics and proper skin care play an important role. The possibilities of normalizing the microbiome of the affected skin areas to restore the skin barrier with the help of dry skin care cosmetics are shown.
A CLINICAL CASE OF UROLOGICAL REHABILITATION OF A CHILD WITH YATROGENIC COMPLICATIONS OF THE URINARY TRACT DUE TO A SPINAL CORD INJURY
Authors: Novoselova Irina N. , Demin N. V. , Ponina I. V. , Ladygina E. A. , Valiullina S. A.
Published: February 2020

The outcome both of patient recovery and spinal injury, in addition to a variety of clinical factors, is significantly affected by consequences and complications occurring during all periods of injury management. In acute, early and intermediate stages, complications of pelvic organs, according to different authors, are found in 77 - 100% of cases. The described clinical case serves as an illustration of irreversible complications had arisen because of improper management of a spinal cord injury (SCI) patient. An inadequate technique for urine diversion, underestimation of specific demands of the SCI patient, lack of proper positioning skills - all mentioned impacts caused inflammatory and trophic disorders. The article discusses an experience of urological rehabilitation specialists treated a child with iatrogenic complications of a urinary tract due to SCI at levels from Th8 to Th10. Particular attention is paid to mistakes made at the early rehabilitation stage and caused iatrogenic obliteration of the urethra in the area of penoscrotal angle and iatrogenic lysis of the bulbar urethra what inevitably worsened patient’s recovery and the quality of his and his family life.
N.I. PIROGOV - SURGEON, SCIENTIST, AND TEACHER: A LOOK FROM THE 21ST CENTURY (ON THE 210TH ANNIVERSARY OF THE GREAT RUSSIAN DOCTOR)
Authors: Ivanyushkin Alexander Y. , Fisenko A. P. , Smirnov I. E.
Published: February 2020

Thanks to the work of the great doctor, scientist and teacher Nikolay Pirogov, Russian science reached the forefront in the field of biomedicine in the XIX century. The article presents a scientific review of the life, medical and scientific activities of Nikolai Pirogov, it presents an analysis of the emergence of the Russian health care system in the XVIII century as part of the social and political reforms of Peter the Great. Since this period, the most important feature of the health care system in Russia is the dominance of statism. The project of Peter I to introduce into Russian society the achievements of scientific medicine in Western Europe contained a contradiction, which can be described as a “conflict of civilizations”. The main sources for this scientific review were Pirogov’s “The Old Physician’s Diary” and the work of his pre-revolutionary biographer Julius Malis. Patriarchal family traditions and the Orthodox religion had an important influence on the upbringing of Nikolay Pirogov in childhood and adolescence. During the years of study of Nikolay Pirogov (1824-1828), the education system at the medical faculty of the Imperial Moscow University was still at the stage when there was an opposition between two parties of professors (“Germans” and “non-Germans” - Aleksandr Gertsen). The historical mission of Nikolai Pirogov is that he plays a leading role to resolve the “conflict of civilizations” in Russian medicine. The period of the Patriotic War of 1812 was notable in Russia for the extraordinary rise of patriotism, which played a major role in shaping the civic worldview of Nikolai Pirogov. But Nikolai Pirogov’s worldview rules out nationalist bias and one-sidedness.
Quality improvement and audits in clinical practice
Authors: Cockcroft Peter
Published: February 2020

Veterinary Evidence champions the use of evidence to enhance the quality of care provided to animals, and I am pleased to announce that the Journal will now include quality improvement case studies.
Enhanced Immunological Recovery With Early Start of Antiretroviral Therapy During Acute or Early HIV Infection–Results of Italian Network of ACuTe HIV InfectiON (INACTION) Retrospective Study
Authors: Muscatello Antonio , Nozza Silvia , Fabbiani Massimiliano , De Benedetto Ilaria , Ripa Marco , Dell’Acqua Raffaele , Antinori Andrea , Pinnetti Carmela , Calcagno Andrea , Ferrara Micol , Focà Emanuele , Quiros-Roldan Eugenia , Ripamonti Diego , Campus Marco , Maurizio Celesia Benedetto , Torti Carlo , Cosco Lucio , Di Biagio Antonio , Rusconi Stefano , Marchetti Giulia , Mussini Cristina , Gulminetti Roberto , Cingolani Antonella , D’Ettorre Gabriella , Madeddu Giordano , Franco Antonina , Orofino Giancarlo , Squillace Nicola , Gori Andrea , Tambussi Giuseppe , Bandera Alessandra
Published: February 2020

Background: Viral load peak and immune activation occur shortly after exposure during acute or early HIV infection (AEHI). We aimed to define the benefit of early start of antiretroviral treatment (ART) during AEHI in terms of immunological recovery, virological suppression, and treatment discontinuation.Setting: Patients diagnosed with AEHI (Fiebig stages I-V) during 2008-2014 from an analysis of 20 Italian centers.Methods: This was an observational, retrospective, and multicenter study. We investigated the effect of early ART (defined as initiation within 3 months from AEHI diagnosis) on time to virological suppression, optimal immunological recovery (defined as CD4 count ≥ 500/µL, CD4 ≥ 30%, and CD4/CD8 ≥ 1), and first-line ART regimen discontinuation by Cox regression analysis. Results: There were 321 patients with AEHI included in the study (82.9% in Fiebig stage III-V). At diagnosis, the median viral load was 5.67 log10copies/mL and the median CD4 count was 456 cells/µL. Overall, 70.6% of patients started early ART (median time from HIV diagnosis to ART initiation 12 days, IQR 6-27). Higher baseline viral load and AEHI diagnosis during 2012-2014 were independently associated with early ART. HBV co-infection, baseline CD4/CD8 ≥ 1, lower baseline HIV-RNA, and AEHI diagnosis in recent years (2012-2014) were independently associated with a shorter time to virological suppression. Early ART emerged as an independent predictor of optimal immunological recovery after adjustment for baseline CD4 (absolute and percentage count) and CD4/CD8 ratio. The only independent predictor of first-line ART discontinuation was an initial ART regimen including > 3 drugs.Conclusions: In a large cohort of well-characterized patients with AEHI, we confirmed the beneficial role of early ART on CD4+ T-cell recovery and on rates of CD4/CD8 ratio normalization. Moreover, we recognized baseline CD4/CD8 ratio as an independent factor influencing time to virological response in the setting of AEHI, thus giving new insights into research of immunological markers associated with virological control.
Profile of Drug Hypersensitivity Patients Hospitalized in Dr. Soetomo Hospital, Surabaya, Indonesia: Preliminary Data of 6 Months Observation
Authors: Isyroqiyyah Nur Moya , Soegiarto Gatot , Setiawati Yuani
Published: February 2020

Drug hypersensitivity is defined as an untoward response to medication which is noxious and unintended, and which occurs at doses normally used in human either for the prophylaxis, diagnosis, or therapy of disease or for the modification of physiological function. Drug hypersensitivity is common and may cause emergency condition until death. The incidence of drug hypersensitivity-related hospitalizations has usually been assessed within hospitals. The aim of this study is to determine the profile of drug hypersensitivity patients hospitalized at Dr. Soetomo Hospital in 6 months period from January to June 2016. This study was a descriptive retrospective study on medical records of drug hypersensitivity patients hospitalized in Dr. Soetomo Hospital in 6 months period. The patient’s demographic data, the type of hypersensitivity reaction, and the final outcome of the hospitalization were collected. Within the 6 months period, there were 16 drug hypersensitivity patients hospitalized in Dr. Soetomo Hospital. Most of them are female (56.25%), and aged between 46-55 years (25%). There were 4 patients (25%) with type I hypersensitivity: urticaria, angioedema and anaphylaxis; while type IV hypersensitivity occured in 12 patients (75%): Stevens-Johnson syndrome, Stevens-Johnson syndrome-Toxic Epidermal Necrolysis overlap, erythroderma, maculopapular drug eruptions, and DRESS. Most of the patients (87.5%) had favorable outcome after hospitalization. There were 16 patients with drug hypersensitivity reaction hospitalized in Dr. Soetomo Hospital, Surabaya in 6 months period. Most of them were female and had type IV hypersensitivity reactions.
Case Report: A Headset in the Bladder
Authors: Soetojo Soetojo , Madani Hasan
Published: February 2020

Foreign objects may be present in the bladder due to deliberate insertion or displacement of the surrounding organs. There have been multiple cases of sharp objects such as nails, hair pins, and screws, as well as large objects such as AAA batteries, toothbrushes, and ballpoint pens found in the urethra and the bladder, which must have been aimed to induce sexual satisfaction associated with mental and psychic disorders. The diagnosis was established by means of  radiological examinations, ie thoracic x-ray, KUB, and urethrography. This article reported a 32-year-old man with headset inserted to penile until bladder and could not be pulled out again. The patient complained pain and bleeding out of the urinary tract. We performed vesicotomy and pulling the out headset from bladder. The operation was succesful. In conclusion, the case of a headset in the bladder has been treated successfully with vesicotomy.
The Effect of Vitamin E Supplementation on Muscular Fatigue in Professional Men's Athletics
Authors: Yusni Yusni , Amiruddin Amiruddin
Published: February 2020

High-intensity exercise (3000-meter runner) contributes to muscle fatigue. Fatigue can be determined by measuring blood lactate levels. Blood lactate levels are a product of anaerobic metabolism. Lactate accumulation due to anaerobic physical activity can inhibit the glycolytic enzyme that affects decreased ATP production, damage of the calcium and sodium pumps in the muscles and causes fatigue. This study aimed to analyze the effect of vitamin E on the level of fatigue through the response of blood lactate levels in the runner 3000 meters. This research was a quasi-experimental research with a pretest-posttest design. Research subjects were 9 volunteer athletes (3000 meters runners) Aceh province, male, and aged 15-20 years. The treatments were vitamin E at a dose of 1x400 IU per day and administered for 14 days. Blood lactate levels were examined using the method of calorimetry. The statistical analysis was using the homogeneity test of variance (Levene's test), the normality test (Kolmogorov-Smirnov test) and paired t-test with a significant level of 5% (p-value<0.05). The results showed that blood lactate levels decreased approximately 13.93% after vitamin E supplementation. There was no significant difference (p=0.27) between blood lactate levels before and after vitamin E supplementation in athletes. In conclusion, vitamin E supplementation did not significantly lower blood lactate levels therefore vitamin E did not significantly reduce muscle fatigue in men's athletics.
Correlation of Population and Environmental Behavior with Rat Density Rate in Plague Disease-Focus, Threatened and Safe Areas in Tutur District, Pasuruan Regency, 2016
Authors: Lestari Evi Noerista , Andajani Susilowati , Hadi Usman
Published: February 2020

Plague disease remains a public health problem in the world. According to the International Health Regulations (IHR), an outbreak is an infectious disease that has the potential to cause an outbreak. The purpose of this study was to analyze a significant relationship between human behavior and the environment with the density of the number of rats in the focus, threatened and outbreak-safe areas in Tutur Regency, Pasuruan Regency, in 2016. This was an observational analytic study with cross correlation sectional where the research variables are population behavior, environment, and the number of rat densities observed once at a time. The results showed that there was no significant relationship between the behavior (knowledge, attitude, and practice) of the population with the density of rats in the focus area of the Surorowo hamlet outbreak, in the endangered outbreaks of the Ngaro hamlet, and in the outbreak-safe area of the North Ngandong hamlet in Tutur District. Whereas, there is a significant relationship between environmental conditions and the amount of rat density in the focus area of the outbreak of the Surorowo hamlet (p: 0.047 or p <0.05), the threatened area of the Ngaro hamlet (p: 0.036 or p <0.05), and at outbreak-safe areas in Andong Utara hamlet (p: 0.047 or p <0.05). Conclusion: Environmental conditions are associated with the amount of rat density either in the outbreak, in focus, threatened, or in safe areas. That it is necessary to control environmental risk factors to reduce the amount of rat density.
Comparison of Antropometry and Physical Abilities between Trained and Untrained Individuals in Second Growth Phase
Authors: Akbar Idzam Kholid , Purwanto Bambang , Setijono Hari
Published: February 2020

The growth and development of the body goes through two phases of rapid growth. First phase (0-5 years) and second phase (10-17 years). This study aimed to compare anthropometry and physical abilities between trained and untrained individuals in the second rapid growth phase (adolescence). This research method used analytic observational with cross sectional design. The sample study used adolescents aged 14 years old, consisted of trained adolescent groups (n=25) and untrained adolescent groups (n=32), with categorized throught the International Physical Activity Questionnaires (IPAQ). Each group measured height, weight, chest circumference, vital lung capacity (VC), oxygen saturation (SpO2), heart rate resting, heart rate exercise, and VO2Max. The results of the different test between trained and untrained groups with a significance level of p<0.05 showed there were significant differences in body height (p=0.000), VC (p=0.000), SpO2 (p=0,001), heart rate rest (p=0.000), and VO2Max (p=0.000). There were no significant differences in body weight (p=0.053), chest circumference (p=0.226), and heart rate exercise (p=0.242). As a conclusion, anthropometry and physical abilities of trained individuals was greater than the untrained individuals in the second rapid growth phase (adolescence).
The Effect of Cinnamomum burmannii Water Extraction Against Staphylococcus aureus, Enterobacter spp., Pseudomonas aeruginosa, and Candida albicans: In Vitro Study
Authors: Novita Bernadette Dian , Sutandhio Silvia
Published: February 2020

Indonesian cinnamon (Cinnamomum burmannii) is a native plant of Indonesia that has a lot of potential. The most consumed part is the bark. This study aims to examine the antimicrobial effect of Cinnamomum burmannii bark extract on various types of pathogenic microbes, namely Staphylococcus aureus, Enterobacter spp., Pseudomonas aeruginosa, and Candida albicans. An experimental study using a water extract (infusion) of Cinnamomum burmannii bark and a microbial test obtained from the Faculty of Pharmacy, Widya Mandala Catholic University, Surabaya. The antimicrobial effect test was carried out by the microdilution method in 96-well-microplate to determine the Minimum Inhibitory Level (MIC) and implantation on solid media to determine the Minimum Kill Rate (KBM). The MIC and KBM against Staphylococcus aureus were 625-1,250 ppm and 1,250-2,500 ppm, respectively. MIC and KBM for Enterobacter spp., Pseudomonas aeruginosa, and Candida albicans were not found at the highest concentrations tested at 10,000 ppm. Cinnamomum burmannii extract can be used as a potential ingredient with antimicrobial effects, especially against Gram-positive bacteria. Future studies should pay attention to the quality of simplicia, particle size, and the most effective extraction methods extracting antimicrobial substances from simplicia.
The Expression of E6 HPV, P53 nd P16ink4a at Well, Moderately, and Poorly Differentiated Cervical Adenocarcinoma
Authors: Mastutik Gondo , Rahniayu Alphania , Kurniasari Nila , Rahaju Anny Setijo , Alia Rahmi , Mustokoweni Sjahjenny
Published: February 2020

The objective of this study is to analyze the expression of E6 Humanpapilloma virus (HPV), p53, and p16INK4A in cervical adenocarcinoma grade well differentiated (WD), moderately differentiated (MD), and poorly differentiated (PD). A cross sectional study conducted at Department of Anatomic Pathology, Dr. Soetomo General Academic Hospital Surabaya Indonesia using formalin fix paraffin embedded (FFPE) from cervical normal and cervical adenocarcioma grade WD, MD, and PD. The expression of E6 HPV, p53, and p16INK4A was performed by immunohistochemistry (IHC) staining. Data were analyzed with Kruskal-Wallis and continued with Mann-Withney test. The expression of E6 HPV in the cervical adenocarcinoma showed 35.9% specimens represented negative and 64.1% specimens represented positive. There was no significant difference in the expression of E6 HPV and p53 in cervical adenocarcinoma between grade WD, MD, and PD. The p16INK4A was overexpressed, shown as diffuse appearance in 89.7% of the specimens. There was a significant difference in the expression of p16INK4A between grade WD and MD with PD. In conclusion, some of cervical adecarcinoma were not caused by infection of HPV type 16 or 18 and the expression of p16INK4A might take a role in the developing of malignancy that caused by infection of HPV.
OSTEOSARCOMA HAS NOT BECOME ATTENTION TO SOCIETY PROFILE OF OSTEOSARCOMA PATIENTS AT DR. SOETOMO GENERAL HOSPITAL SURABAYA “A RETROSPECTIVE STUDY”
Authors: Mahyudin Ferdiansyah , Edward Mouli , Basuki Muhammad Hardian , Bari Yunus Abdul , Suwandani Yesa
Published: February 2020

Background: Osteosarcoma is the most common bone neoplasm found in the community but evaluation osteosarcoma cases in RSUD Dr. Soetomo has not been updated since 1995.Purpose: This study o osteosarcoma patient characteristic as well as therapy at Dr. Soetomo General Hospital in 2007 to 2016. It expects to show survival rates of osteosarcoma patient, so it can be a reference for searching the problems in the treatment of osteosarcoma cases and helps to decide treatment for osteosarcoma.Research Methods: Descriptive retrospective study, conducted on osteosarcoma patients at Dr. Soetomo General Hospital during 2007-2016 periods. Data were obtained from Ortho tumor patient database, and contacting them by phone or home visit.Results: Osteosarcoma patients was found mostly in 2015, while the least in 2008, with trend increasing by time. Majority of the patients came with advanced stage. Osteosarcoma treated mostly by amputation, either with or without chemotherapy. The survival rate in the first, second, or the fifth year was found lower than other references. Most common cause of mortality was the metastasis.Conclusion: Awareness of the society about the cancer sign of cancer and desire to use medical treatment as a priority is still low. This causes a low early detection rate of osteosarcoma and a high rate of metastatic cases because of inappropriate early treatment. Further socialization and increased awareness of medics about the suspicion of osteosarcoma are needed to improve the success rate of treatment as well as the survival rate.
LONG TERM FUNCTIONAL EVALUATION AUTOFIBULAR STRUT GRAFT IN CASE OF FRACTURES NECK FEMUR IN RSUD DR SOETOMO SURABAYA
Authors: Sjarwani Achmad , Irsyam OK Ilham Abdullah
Published: February 2020

Background: Neck femur fracture has a poor prognosis due to its anatomical structure. Fractures that occur in the elderly often have a heavy comorbid so that the mortality rate in 1 year in this case reaches 30-50%. The techniques that have been developed at this time are not satisfactory results with non-union rate of about 30%.Purpose: Assessing the long-term effectiveness of fibular auto strut graft techniques for neck femoral fracture therapy.Methods: The study was conducted retrospectively using primary data in the form of clinical evaluation and secondary data in the form of medical record data and questionnaires of neck femur fracture patients who performed non-vascularized autofibular strutgraft therapy in the period January 2005 to August 2015 in operating room IRD RSUD Dr. Soetomo Surabaya. Patients were evaluated with Harris Hip Score.Result: Medical record data shows that surgery was performed in January 2005 until August 2015 in the IRD hospital operating room. Soetomo Surabaya with 15 patients that fit criteris inclusion. The final result of Harris Hip Score is excellent in 66.66% of patients, good in 20% of patients, and poor on 13.33% of patients. It can be seen that in large part, the technique of autofibular strutgraft (Surabaya Technique) gives good results to the sufferer.Conclusion: Autofibular strutgraft and reinforcement with cancellous lag screw on neck femur fracture can generally provide good functional results in long term evaluation. From the assessment of functional aspects, abnormal anatomical conditions, and Range of Motion (ROM), obtained satisfactory results. This supports autofibular strutgraft as a neck femur fracture therapy as a major therapeutic option at a young age.
BIOMECHANICAL COMPARATIVE STUDY BETWEEN TENSION BAND WIRING, DOUBLE ENDO BUTTON AND HOOK PLATE FOR ACROMIOCLAVICULAR JOINT INJURY
Authors: Ramawan Erwin , Afrian MDS Jifaldi
Published: February 2020

Background: The treatment for acromioclavicular joint injury are debatable, there are fixation options include tension band wiring, AC joint reconstruction and hook plate These fixations are capable of providing a stable fixation, but controversy still exists that mentions the superiority of each of these fixationsPurpose: To compare biomechanical stability of 3 fixation include tension band wiring, double endo button, and hook plate to provide a scientific basis of the fixation.Methods: This research is an experimental in vitro. Using 27 acromioclavicular joints cadaver divided into three groups that performed tension band wiring fixation, double endo button and hook plate. Each fixation evaluated with 10, 20, 50 and 100 times repetitions with 100N traction force.Results: Tension band wiring gives the smallest displacement. In 10 times repetition average displacement of tension band wiring 0.056 mm (p = 0.000) compared to double endo button 1.622 mm and hook plate 0.867 mm. In 20 times repetitions, tension band wiring 0.1667 mm (p = 0,000) compared to double endo button 3.1778 mm and hook plate 1.1111 mm. In 50 times repetition, tension band wiring 0.3111 mm (p = 0.000) with double endo button 4.7778 mm and hook plate 1.3556 mm. In 100 times repetitions, tension band wire 0.556 mm (p = 0.000) while double endo button 5.4444 mm and hook plate 1.4556 mm.Conclusion: Tension band wiring have a good stability compared to double endo button and hook plate. But all of fixation provide stability for acriomioclavicular joint motion.
EFFECT OF PLATELET RICH FIBRIN AND MESENCHYMAL STEM CELL ON MYOBLAST AND FIBROBLASTS RATIO IN RABBIT MUSCLE DEFECT
Authors: Utomo Dwikora Novembri , Chilmi Mohammad Zaim , Fiandana Angga
Published: February 2020

Background: One of the problems in Orthopedics which often results in less satisfactory outcomes is the muscle injuries treatment. This is due to slow healing process and outcome has not been optimal because it produces scar tissue.Purpose: To evaluate effect of platelet rich fibrin and allogenic mesenchymal stem cell on muscle regeneration through comparation of myoblast and fibroblast ratio.Methods: This research is true experimental with randomized pre and post test with control group design. The treatment group included administering allogenic mesenchymal stem cells (MSC), rich fibrin platelets (PRF), and a combination of both. The study subjects were New Zealand White Rabbit which gastrocnemius muscle is incised. Muscle quality evaluation was done in the second and fourth weeks through histology examination in the form of myoblast cell ratio to fibroblast.Results: In the second week evaluation, administering allogenic MSC combined with PRF gave significant results to an increase in myoblast cell ratio to fibroblast. While evaluation of fourth week, giving of three treatment groups gave significant result to myoblast cell ratio to fibroblast.Conclusion: Allogenic MSC administration combined with PRF can improve New Zealand White Rabbit muscle healing quality by histological examination.
DOUBLE FREE FUNCTIONING MUSCLE TRANSFERS FOR BRACHIAL PLEXUS INJURIES: A CASE REPORT
Authors: Suroto Heri , Wardhana Teddy Heri , Ridhalhi Farindra
Published: February 2020

Free functional muscle transfer for brachial plexus injury is one of the alternatives to repair the upper extremity function, where usually one type of muscle is used, the gracillis. The method of using two donor muscles to restore the motor function is worth considering for a better improvement of the quality. A 36 years old man with a complete left brachial plexus injury from C5-T1 due to motorcycle accident. A double free functional muscle transfer was performed using the gracillis muscle and the adductor longus muscle with the arterial source from the thoraco-acromial artery with the phrenic and accessory nerves. The gracillis muscle is used to flex the fingers while the adductor is used for flexing the elbow. A one year post-operative evaluation showed the patient was already capable of flexing his elbow with the muscle score of 3 and also the fingers with the muscle score of 1. The double free functional muscle transfer procedure is effective in achieving the moving function of both the elbow and the hand.
CONGENITAL SCOLIOSIS: AN ARTICLE REVIEW
Authors: Irianto Komang Agung , Yazid Hizbillah
Published: February 2020

Background: Congenital Scoliosis (CS) defined as vertebral lateral deviation which forms during the intrauterine embryonic phase, carrying incidence between 0,5-1 per 1000 births. Mortality rate increases in untreated case, especially due to pulmonary problem (40%).Contents: CS can range from hemivertebrae (HV) which may be single or multiple, vertebral bar with or without HV, block vertebrae, wedge shaped or butterfly vertebrae. The risk factors for progression include: type of defect, site of defect, and the patient’s age. Plain radiographs remain standard diagnosis. MRI evaluation should be considered. The goal of managing CS is to obtain a balanced trunk and spine while maintaining as much normal spinal growth as possible and preventing neural deficit. Non-operative management is including observation, brace, and traction. The operative procedures are broadly divided into (a) those preventing further deformity: in situ fusion, convex hemiepiphysiodesis, and HV excision, (b) those that correct the present deformity: hemiepiphyseodesis & hemiarthrodesis, single & dual growing rods, HV excision, and reconstructive osteotomy.Conclusion: The treatment of CS remains one of the more challenging aspects of pediatric orthopaedic surgery. Operative treatment should be reserved for patients whom non-operative management didn’t meet the criteria or failed.
LEVEL OF PROCALCITONIN PLASMA AS AN EARLY SEPSIS BIOMARKER IN POLYTRAUMA PATIENTS IN DR HASAN SADIKIN GENERAL HOSPITAL BANDUNG
Authors: Wibowo Ricky , Rasyid Hermawan Nagar , Ismono Darmadji
Published: February 2020

Background: Polytrauma patients have a risk of progressive organ dysfunction due to uncontrolled immunological process. Sepsis and multiple organ failure are the most common causes of morbidity and mortality in late death of polytrauma patients. Clinical diagnosis and routine laboratory test are not specific until the patient entered a critical state. Delayed diagnosis of sepsis is caused by difficulties in diagnosing. Procalcitonin is a biomarker that is useful in predicting the onset of sepsis. The aim of this research is to determine the level of procalcitonin as early biomarker sepsis in polytrauma patients in RSHS Bandung. Methods: A diagnostic study using secondary data from the Academic Leadership Grant (ALG) study on polytrauma patients in Emergency Room of RSHS Bandung from January-June 2017. This study determined the cut of point, sensitivity, spesificity, Positive Predictive Value (PPV), Negative Predictive Value (NPV), and accuracy to diagnosis sepsis.Result: A total of 70 subjects were enrolled in this study, 92.9% were male gender with average age 33.21±13.395 years old. Twenty-one patients (30%) were diagnosed with sepsis. Based on receiver operating characteristic (ROC) curve showed the level of procalcitonin was given in the area under curve (AUC) 0.96 with Confidence Interval 0.923-1.00 (p < 0.05). The Procalcitonin cut of point was 1.46 ng/mL with a sensitivity of 90.5%, specificity of 89.8%, PPV of 79.2%, NPV of 95.7%, and accuracy of 90.0%.Conclusion: Plasma Procalcitonin 1.46 ng/mL is a good predictor for early diagnosis sepsis toward polytrauma patients.