bluuebunny/crossref_metadata_2025 huggingface dataset:
Antiparkinson drugs use and adherence in older adults and associated factors: an integrative review
Authors: Medeiros Géssica Cazuza de , Silva Gabriela Avelino da , Asano Nadja Maria Jorge , Coriolano Maria das Graças Wanderley de Sales
Published: February 2023

Abstract Objectives To identify factors associated with antiparkinson drugs use and adherence in older adults with Parkinson's disease (PD) through an integrative literature review. Method An integrative literature review involving a search for relevant publications in Portuguese, English, and Spanish on the electronic databases LILACS, MEDLINE - via PubMed, Web of Science and Scopus, without restriction regarding date or study design, was carried out during the period August-September 2021. The selection of studies was performed independently by two reviewers and the final validation conducted by a third reviewer. Results After applying the eligibility criteria, 5 of the 460 studies found were included in the review. Results showed moderate adherence rates (range 35.3-66.8%) and the main factors associated with lower adherence to antiparkinson therapy were older age, cognitive deficit, greater motor impairment, multimorbidities, change in therapy regimens, depression, polypharmacy, lower education, non-white ethnicity and male gender. Factors associated with greater adherence were younger age, white ethnicity, no change in therapy regimen, higher level of knowledge about PD, good clinical control, higher educational level, married status, higher income and greater level of awareness. Conclusions Non-adherence to antiparkinsonian therapy was frequent and multifactorial., Understanding this behavior is important to help inform the scientific community and devise public policies and strategic planning in health services for improving the quality of life of the older population.
Adesão terapêutica ao uso de antiparkinsonianos em pessoas idosas e seus fatores associados: revisão integrativa
Authors: Medeiros Géssica Cazuza de , Silva Gabriela Avelino da , Asano Nadja Maria Jorge , Coriolano Maria das Graças Wanderley de Sales
Published: February 2023

Resumo Objetivos Identificar os fatores associados à adesão terapêutica ao uso de antiparkinsonianos em idosos com Doença de Parkinson (DP) por meio de uma revisão integrativa da literatura. Método Trata-se de uma revisão integrativa de literatura nos idiomas português, inglês, espanhol, nas bases de dados eletrônicas LILACS, MEDLINE - via PubMed, Web of Science e Scopus, sem restrição quanto ao tempo e desenho de estudo, realizada no período de agosto a setembro de 2021. A seleção dos estudos foi realizada de maneira independente por dois revisores e a validação final por um terceiro revisor. Resultados Após a aplicação dos critérios de elegibilidade, dos 460 estudos encontrados, foram incluídos cinco estudos que evidenciam taxas moderadas de adesão, variando de 35,3% a 66,8%, e apontam como principais fatores associados à menor adesão à terapia antiparkinsoniana: idade mais avançada, deficit cognitivo, maior comprometimento motor, multimorbidades, alteração nos regimes terapêuticos, depressão, polifarmácia, menor escolaridade, não brancos e sexo masculino. Foram fatores descritos para maior adesão: idade mais jovem, cor branca, sem modificação de regime terapêutico, maior nível de conhecimento sobre a DP, bom controle clínico, educação, ser casado, maior renda e nível de consciência. Conclusões A não adesão à terapêutica antiparkinsoniana é frequente e de dimensão multifatorial, sua compreensão torna-se relevante para subsidiar dados para a comunidade científica, objetivando a criação de políticas públicas e planejamento estratégico em serviços de saúde com o propósito de melhorar a qualidade de vida da pessoa idosa.
A Carta do Levantamento Arquitetônico: leitura comentada e estado da arte de uma disciplina contemporânea
Authors: SAVIANE BENJAMIM MOTTA
Published: February 2023

RESUMO Mensurar, registrar, representar, enfim… documentar o espaço existente (antropizado ou não) se configura como um interesse estratégico muito sedimentado na cultura ocidental. Já em contexto moderno, em grande medida, a partir do século XIX, essas práticas acabaram adquirindo uma ramificação específica para a arquitetura, sofrendo notória influência de “interesses preservacionistas”, mesmo se compreendidos de maneira difusa. Talvez, como resultado desse processo, a documentação arquitetônica ainda seja vista, por vezes, como prática subsidiária da disciplina da restauração. Contudo, uma abordagem aprofundada sobre esse tema pode revelar um desenvolvimento científico específico, com relativa independência disciplinar, que merece ser analisado com a seguinte finalidade: proporcionar a melhor utilização de uma importante ferramenta para o campo da preservação como um todo, ou seja, não apenas como subsídio a trabalhos diretamente envolvidos com o restauro arquitetônico, mas também para as disciplinas da história e arqueologia e seus congêneres vinculados à arquitetura (como história da arquitetura e arqueologia da arquitetura). Nesse sentido, o presente artigo procura subsidiar uma contextualização precisa, em que são examinados alguns desenvolvimentos recentes da temática, abordados a partir da Carta do levantamento arquitetônico, documento internacional de referência, para o qual apresentamos uma tradução diretamente do italiano, trazida originariamente em nossa dissertação de mestrado e aqui comentada à luz da produção bibliográfica. A limite, nossa investigação almeja contribuir para pacificar a compreensão de um aspecto ainda pouco discutido no contexto brasileiro: afinal, o levantamento arquitetônico se constitui enquanto prática ou disciplina?
Poder por meio de perguntas: interrogatório do ex-presidente Lula
Authors: Cabral Débora
Published: February 2023

Resumo Este artigo tem por objetivo identificar o exercício do poder institucional por meio de perguntas feitas pelo ex-juiz Sergio Moro quando do depoimento do ex-presidente Luiz Inácio “Lula” da Silva, em maio 2017. Para isso, serão analisadas as perguntas feitas pelo ex-juiz naquele momento. A forma como as perguntas são elaboradas é uma ferramenta de exercício de poder conhecida na Linguística, no entanto, no que tange à oitiva do acusado, ainda não há pesquisas no âmbito do Judiciário brasileiro. Para contribuir com essa área, o presente artigo investiga, quantitativa e qualitativamente, como as perguntas exerceram controle sobre a fala do acusado e até que ponto há características de confrontação nas falas do ex-juiz. O estudo tem como pressuposto teórico os estudos críticos do discurso desenvolvidos por Teun A. van Dijk (2018). Os resultados mostram que o estilo de fazer perguntas adotado pelo ex-juiz naquele episódio tem traços acusatórios e lembra interrogatórios policiais.
PRÁCTICAS DE LIDERAZGO EN ESCUELAS CON ORIENTACIÓN INCLUSIVA Y BUENOS RESULTADOS ACADÉMICOS
Authors: Valdés René
Published: February 2023

RESUMEN El objetivo de este estudio es explorar y describir las prácticas de liderazgo presentes en escuelas identificadas como inclusivas y a la vez con buenos resultados académicos. Para ello se sistematizaron tres estudios de casos con enfoque etnográfico. Los principales resultados muestran la presencia de un liderazgo distribuido, pragmático y estratégico, comprometido con la inclusión y con una gestión pedagógica con foco en la diversidad. Además, estas escuelas destacan por un fuerte desarrollo profesional y por la presencia de una cultura escolar inclusiva. Sin embargo, los hallazgos muestran que los líderes participantes entienden las pruebas estandarizadas como herramientas de información y no perciben la supremacía del rendimiento escolar como una barrera para la inclusión.
POLÍTICAS EDUCATIVAS PARA LA INNOVACIÓN, INCLUSIÓN Y TIC EN BOLIVIA, PARAGUAY Y URUGUAY
Authors: Manzanilla-Granados Héctor Manuel , Navarrete-Cazales Zaira , López-Hernández Paola Andrea
Published: February 2023

RESUMEN Este artículo tiene como objetivo presentar un análisis de las políticas educativas planteadas en tres planes nacionales de formación: Plan Sectorial de Desarrollo Integral de Educación 2016-2020 (Bolivia), Plan de Acción Educativa 2018-2023 (Paraguay) y Plan Nacional de Política Educativa 2020-2025 (Uruguay), atendiendo como categorías centrales el desarrollo de: 1) la innovación, 2) la inclusión y 3) las Tecnologías de la Información y Comunicación (TIC), empleando una metodología comparativa que permite ubicar semejanzas y diferencias para encontrar tendencias expuestas en cada plan. Con base en los resultados obtenidos se concluye que comprender la simbiosis entre innovación, inclusión y TIC requiere de un análisis profundo en el que se visualice la vinculación de dichas categorías, en un proceso mediante el cual se conectan y reconectan para lograr una mejora del aprendizaje.
PARTICIPAÇÃO POPULAR NA FORMULAÇÃO DE POLÍTICAS EDUCACIONAIS: A CAMPANHA E O NOVO FUNDEB
Authors: Guerra Luiz Antonio
Published: February 2023

RESUMO Este trabalho realiza um estudo sobre o caso da tramitação legislativa e aprovação do novo Fundo de Manutenção e Desenvolvimento da Educação Básica e de Valorização dos Profissionais da Educação em 2020, com objetivo de analisar a atuação da Campanha Nacional pelo Direito à Educação como um exemplo paradigmático de participação da sociedade civil na elaboração de políticas públicas educacionais. Para tanto, recorre-se à investigação dos documentos produzidos pela rede, sob a luz de teorias sobre políticas públicas e movimentos sociais. Conclui-se que a inserção na arena decisória dos segmentos da população mais afetados pelas políticas públicas em discussão é um caminho necessário para a ampliação dos direitos sociais e para que avancemos no caráter substancial da democracia brasileira.
A INTERIORIZAÇÃO DA PERFORMATIVIDADE PELAS CRIANÇAS: LÓGICAS DE FABRICAÇÃO DO BOM ALUNO NO ENSINO PRIMÁRIO
Authors: Diogo Ana , Ferreira Manuela , Melo Benedita Portugal e
Published: February 2023

RESUMO O desempenho académico dos alunos tornou-se uma preocupação central, no quadro da alteração dos modos de regulação dos sistemas educativos. Em que medida a ideologia da performatividade estará a ser interiorizada pelas crianças do ensino primário português? A análise de entrevistas a alunos do 3º ano de três escolas distintas sobre o que é um bom aluno aponta para três lógicas: i) a das aptidões naturais para a aprendizagem, ii) a do trabalho escolar tradicional e iii) a do trabalho escolar competitivo. As duas primeiras evidenciam a permanência do modelo de escola típico da primeira modernidade; a lógica escolar competitiva aponta para a reconfiguração precoce do ofício de aluno no quadro de um mandato educativo ancorado nos valores da performance e individualização.
EXPERIMENTAL STUDY ON IMPROVING HEAT TRANSFER ABILITY OF A HEAT PIPE UTILIZING IRON OXIDE-FERRIC OXIDE HYBRID AND NICKEL FERRITE MONO-MAGNETIC NANOFLUIDS
Authors: Babat Rand Ahmed Adeeb , Sözen Adnan
Published: February 2023

Heat carrier refining of a heat pipe employing the iron oxide-ferric oxide hybrid magnetic nanofluid and nickel ferrite mono-magnetic nanofluid as an operating medium in the process of various performing conditions was investigated experimentally. A thermosyphon-type heat pipe constructed of copper with 20-mm internal and 18-mm external diameters was used in this experimental work. The fulfillment of the heat pipe was examined by operating three separate operating fluids: distilled water, hybrid and mono-magnetic nanofluids. The fluid was injected into the system with a filling ratio equal to 1/3 of the total volume of the heat pipe for all individual experiments. Practical analysis was performed under three distinct input heats and two different nanofluid weight percent as an operating medium in the evaporator section and three different coolant mass flow rates in the condenser area of the system. Wall temperature fluctuations, index factor (efficiency), Nusselt number, and thermal resistance magnitudes were obtained for distilled water, iron oxide-ferric oxide hybrid magnetic nanofluid, and nickel ferrite mono-magnetic nanofluid for each experiment. The highest improvement rates in heat transfer ability, Nusselt number, and heat pipe thermal resistance magnitude were 30.55%, 26.9%, and 61.8%, respectively, when the iron oxide-ferric oxide hybrid magnetic nanofluid was employed as an operating fluid compared to distilled water. The thermal performance of the system increased significantly with increasing the weight percent of both hybrid and mono-magnetic nanofluids. Basically, the efficiency of the system was improved by 3.92% by increasing the weight percent of the hybrid magnetic nanofluid from 0.5 wt.% to 1 wt.%.
La propuesta de valor como elemento clave para innovar en el modelo de negocio del periodismo deportivo: comparativa de estudios de caso en España
Authors: Marín Sanchiz Cristian Ramón , González-Esteban José Luis , Carvajal Miguel , Valero-Pastor José María
Published: February 2023

El periodismo deportivo se ha configurado en uno de los nichos de mercado más innovadores y la teoría de las capacidades dinámicas permite describir los procesos para innovar en el modelo de negocio de las empresas informativas. A través de una comparativa de estudios de caso, este artículo analiza la situación actual y la evolución de tres medios de comunicación (ElDesmarque, Panenka y 2Playbook) en seis áreas: propuesta de valor, capacidades, posicionamiento, mercado, modelo de ingresos y misión. Se observa quelos tres casos disponen de una propuesta de valor bien definida y diferenciada de los competidores. Esta propuesta se sustenta sobre la existencia de una serie de capacidades y recursos competitivos que le otorgan ventajas competitivas difícilmente imitables, como el talento humano. La innovación en modelos de negocio a través de las capacidades dinámicas (exploración, explotación y reconfiguración) es un factor clave para garantizar la sostenibilidad de una empresa que opera en el sector del periodismo deportivo.
INVESTIGATION OF THE EFFECT OF OLANZAPINE AND L-CARNITINE ON RAT TESTIS TISSUE
Authors: AKKUŞ Merve , KILIÇ Faruk , AŞCI Halil , CANKARA Fatma Nihan , SAVRAN Mehtap , ULUSOY KARATOPUK Dilek
Published: February 2023

Objective

Olanzapine has adverse effects on sexual dysfunction.

There are a limited number of studies showing that it

also causes structural changes in the reproductive

system. This study aimed to examine the effects of

L-Carnitine on testicular damage caused by Olanzapine

in terms of histopathological, sperm parameters, and

biochemical aspects.

Material and Method

A total of 48 adult Sprague-Dawley male rats were

used in our study. Rats were divided into 6 groups,

8 rats in each group: the Control group (C), 200 mg/

kg L-Carnitine administered group (LC), 2 mg/kg low

dose Olanzapine administered group (LOZN), 2 mg/kg

Olanzapine, and 200 mg/kg L-Carnitine administered

group (LOZN+LC), 4 mg/kg Olanzapine administered

group (HOZN), 4 mg/kg Olanzapine and 200 mg/

kg L-Carnitine administered group (HOZN+LC).

Testicular tissues were used for the determination of

MDA, IL-1B, IL-6, TAS, TOS levels, and histological

evaluation.

Results

In the groups receiving Olanzapine, a decrease in

sperm count, an increase in MDA, IL-1β, TOS values,

and dose-dependent histopathological changes in

testicular tissue were observed. Histopathological

changes were found at a lower rate in the Olanzapine

and L-Carnitine administered groups compared to the

Olanzapine-only groups.

Conclusion

It was concluded that the degenerative histological

findings in the testicular structure observed in the

high-dose Olanzapine administered groups might be

caused by the oxidative stress induced by Olanzapine

in the testicular tissue. L-Carnitine, on the other hand,

was thought to be effective in reducing testicular

degeneration by reducing oxidative damage.
Protoplast Formation and Purification for Coccidioides v1
Authors: M. Barker Bridget
Published: February 2023

This protocol will allow the researcher to create protoplast of Coccidioides spp.
Trinity College Botanic Garden long-term monitoring program v1
Authors: Yajima Midori
Published: February 2023

Botanic gardens hold large, documented, and accessible collections of living plants. These represent unique subsets of taxa from different biogeographical regions growing under common environmental conditions, connecting people to global plant research and conservation efforts while offering a place beneficial for human health and wellbeing. Despite Botanic Gardens being an ideal setting for climate change research, their potential for comparative, long-term studies and outreach in the field is still underutilised. As part of its ten year strategy, Trinity College Botanic Garden (TCBG) aims to tap this potential and establish a programme for long-term (>30 years) monitoring of key physiological performances in its living woody plant collection. The programme will also assess particulate pollution (PM10 and PM2.5) interception by the same trees, pairing climate change and urban green research. Importantly, the project will include the design of a transferable protocol, produce vouchered herbarium specimens as a future historical archive and as a pedagogical tool, and support the garden outreach strategy, so as to nurture its link with both Trinity College Dublin and local communities, ensuring the garden’s legacy into the future.
Preliminary qualitative phytochemical analysis v1
Authors: Mahmood Matin , Hameed Abd Abdulkareem
Published: February 2023

Plant extraction is a process that aims to extract certain components present in plants. It is a solid/liquid separation operation: a solid object (the plant) is placed in contact with a fluid (the solvent). The plant components of interest are then solubilized and contained within the solventChemical tests were carried out using the ethanolic extracts from plants and different fractions, using standard procedures to identify the active constituents
Planet Microbe Semantic Web Application v2
Authors: Blumberg Kai
Published: February 2023

Tutorial for the use of the Planet Microbe Semantic Web Application, accompanying the PhD dissertation work of Kai Blumberg.
MTT (Assay protocol v1
Authors: Hameed Abd Abdulkareem , Mahmood Matin
Published: February 2023

MTT ((3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide)) is used to assess cell viability as a function of redox potential. Actively respiring cells convert the water-soluble MTT to an insoluble purple formazan. AMJ13: 2 (Ahmed.Murtuda ,Jabria 2013)cell line: The cell line of breast cancer has been obtained from Iraqi breast cancer which originated from the prime tumor of an old Iraqi woman (70 years) with a histological identification with carcinoma of infiltrating ductal (1). SK-GT-4:esophageal carcinomacell line was established from a primary tumors in 1989 from a 89 year-old Caucasian male who presented with dysphagia secondary to a well-differentiated adenocarcinoma arising in the Barrett epithelium of the distal oesophagus
KASP genotyping v1
Authors: not provided FishFloorUCL
Published: February 2023

KASP is a genotyping assay which you can use to differentiate wild types vs heterozygous vs homozygous larvae/finclips. It is well suited to genotype a SNP or a small CRISPR-generated indel. Once you confirmed it is working well, the assay is pretty fast to run so you may want to use KASP if you will routinely genotype tens of samples.
Öğretim Elemanları için Aktif Öğrenme Uygulamaları Ölçeğinin Geliştirilmesi
Authors: İLHAN Elif , ÇAM Şefika Sümeyye
Published: February 2023

Bu çalışmanın amacı öğretim elemanlarının aktif öğrenme uygulama düzeylerini belirlemek amacıyla geçerli ve güvenilir bir ölçek geliştirmektir. Bu amaçla oluşturulan madde havuzu, alan uzmanlarına gönderilmiştir. Uzmanlardan gelen dönütlere göre gerekli düzeltmeler yapılarak 40 maddelik bir taslak form oluşturulmuştur. Açımlayıcı Faktör Analizi (AFA) aşaması için 294, Doğrulayıcı Faktör Analizi (DFA) aşaması için 175 öğretim elemanı olmak üzere toplamda 469 katılımcıya ulaşılmıştır. Katılımcılardan elde edilen veriler ile SPSS programı yardımıyla AFA yapılmıştır. Analiz sonuçlarına göre “İşbirliği Sağlama”, “Dijital Öğrenme Teknolojilerini Kullanma”, “Zihinsel Süreçleri Etkinleştirme”, “Soru Sormaya Teşvik Etme” ve “Görevler Verme” olmak üzere 5 faktör ve 28 maddeden oluşan bir yapıya ulaşılmıştır. AFA ile ortaya konulan yapının doğrulanması için ise Mplus 8.4 programında DFA yapılmıştır. Ölçeğin alt faktörleri arasındaki ilişkinin olumlu ve anlamlı olduğu belirlenmiştir. Alt faktörlerin aktif öğrenme uygulamaları olarak adlandırılan bir ana yapının bileşenleri olduğu ve bu bileşenlerin bir araya gelerek bir üst yapıyı oluşturduğu doğrulanmıştır. Modelin uyum iyiliği indeksleri değerleri χ2/sd= 1,62, RMSEA= 0,060, SRMR= 0,070, CFI= 0,90 ve TLI= 0,89 olarak bulunmuştur. Son olarak, ölçeğin tümü ve alt faktörleri için Cronbach alfa iç tutarlılık katsayısı 0,93 olarak hesaplanarak ölçeğin güvenirlik kanıtları elde edilmiştir.
THE FORMATION OF STRATEGIC POLICY DIRECTIONS IN THE SPHERE OF PROVIDING HOUSING FOR FORCEDLY DISPLACED PERSONS
Authors:   Taras Shevchenko National University of Kyiv, Ukraine, Litva Ludmila , Kozachkova Anna ,   Taras Shevchenko National University of Kyiv, Ukraine, Pokusai Vladyslava ,   Taras Shevchenko National University of Kyiv, Ukraine
Published: February 2023

This article presents an overview of the strategy for providing housing provision to forcibly displaced persons and persons whose homes were destroyed due to military actions. Features are considered of the formation of social policy in the field of providing social housing for forcibly displaced persons since 2014, when the annexation of Crimea and the occupation of parts of Donetsk and Luhansk regions by the Russian Federation. The purpose of the article is to analyze state and regional initiatives to provide housing for persons who lost their housing as a result of the war, and to determine ways to optimize the activities of social workers in the field of providing housing for these categories. The research method was the analysis of international and domestic legislation in the field of ensuring the right of forcibly displaced persons to basic shelter and housing, the strategy of the Program of the President of Ukraine "Great Construction" regarding ways to solve the problem of housing for persons who lost their housing as a result of the war, and regional initiatives of executive authorities, territorial communities, individual investors, which are made public in open sources. Caveats and barriers to the implementation of these initiatives, technologies for optimizing the process of providing social services to forcibly displaced persons and persons who lost their housing because of military actions are discussed. It is proposed to implement specialization of a social broker for social workers, which includes information-analytical and advisory activity for optimizing the formation of a package of social services for the specified categories of persons. This specialization will become relevant in conditions of solving wide-ranging problems as part of housing provision after the war. The article notes the leading role of information support for the activities of social workers, especially implementation of Unified information system of the social sphere, which provides accounting and control over the provision of social services. The resources of the System will let to create social portraits of forcibly displaced persons and targeted housing provision for them.
YOLSUZLUK VE TERÖRİZM ARASINDAKİ NEDENSELLİK İLİŞKİSİ: ORTA DOĞU VE KUZEY AFRİKA ÜLKELERİ
Authors: ÖZKAYA Mehmet Hilmi
Published: February 2023

Yolsuzluk ve terörizm, dünyada bazı gelişmekte olan ve az gelişmiş ülkelerin iki yaygın özelliğidir. Bu çalışma, nedensellik analizini kullanarak 2007-2019 döneminde 12 Orta Doğu ve Kuzey Afrika ülkesinde yolsuzluk ve terörizm arasındaki iki yönlü ilişkiyi incelemektedir. Nedensellik analizi bulguları, Ürdün'de yolsuzluk ve terörizm arasında çift yönlü bir nedensellik, Suudi Arabistan ve Tunus'ta yolsuzluktan terörizme doğru tek yönlü bir nedensellik ve Fas ile Yemen'de terörizmden yolsuzluğa doğru tek yönlü bir nedensellik ortaya koymuştur.
Embolization of the arteries in the relief of joint and near joint pain: how, when and in whom? A review
Authors: Medjidov Kamal M. , Parshikov Mikhail  V. , Ginzburg Leonid  M. , Solov’yev Yuri  S. , Uzhakhov Ibragim  M.
Published: February 2023

This paper presents the results of embolization of popliteal artery branches as an innovative technique to treat pain syndrome not relieved by standard conservative methods for osteoarthritis of the knee joint. The study aimed to evaluate available data on the efficacy and safety of popliteal artery branch embolization in the treatment of pain syndrome in osteoarthritis. Relevant studies on the use of embolization at various degrees of gonarthrosis were analyzed. The results were evaluated using the visual analog scale and Western Ontario and McMaster University Osteoarthritis Index. The performance of patients improved based on both scales, and minor complications resolved on their own. Embolization of the branches of the popliteal artery with insufficiency is a promising and effective treatment method for patients with pain due to osteoarthritis of the knee joint of various degrees, and no serious complications have been identified in the procedures, making it safe.
A Real-Time Seismic Intensity Prediction Framework Based on Interpretable Ensemble Learning
Authors: Hu Jinjun , Ding Yitian , Zhang Hui , Jin Chaoyue , Wang Zhongwei
Published: February 2023

Real-time seismic intensity estimation aims to predict the maximum possible damage caused by an earthquake based on primary waves (P wave), so that the earthquake early warning (EEW) targets can take measures to reduce the potential damage according to the predicted seismic intensity. The peak P-wave displacement amplitude (Pd) is often used as an effective characteristic parameter to predict ground-motion peaks; however, it is difficult to accurately predict the complex nonlinearity between P wave and the peak ground motion using a single parameter. To address this problem, we propose a reliable and efficient real-time seismic intensity prediction framework by investigating and comparing the performance of multiple ensemble learning algorithms using the Kyoshin network (K-NET) dataset, with 52,560 sets of three-component records from 2010 to 2018 as training and test sets, and 9166 sets obtained from 2019 to 2021 as a case study. The proposed framework optimizes the ensemble learning models according to the correlation between characteristic parameters to eliminate redundant and irrelevant parameters. An optimal model with 14 characteristic parameters is determined. In addition, we apply interpretable approaches to explain the effects of different parameters on the results in response to the fact that the poor interpretation of machine learning methods leads to low credibility. We verify the efficiency and prove the generalizability of the model using case sets. The results show that the optimized model can predict the maximum intensity with an accuracy rate exceeding 95% within the 1 s time window after the arrival of P wave, and the accuracy stabilizes at more than 97% after 3 s. The framework established in this study can effectively and continuously predict seismic intensity and provide a potential method for EEW.
Deflection Estimation for Structural Health Monitoring using Computer Vision Algorithm
Authors:   , Singh Ranvijay , Bartoli Ivan
Published: February 2023

Typical Structural Health Monitoring (SHM) systems are based on the use of conventional sensors designed to measure strain, displacement, acceleration, tilt, ect. Such data collection and sensing systems are robust and well known but they can be costly and require training. New opportunities are today offered by high resolution cameras that have become widely available and affordable and that are nowadays available even in smartphones. The main objective of this thesis is to explore how high resolution cameras and computer vision algorithms can be used in SHM applications, in particular, for deflection measurement of bridge structures. In the proposed structural sensing system, the collected data is obtained using a series of vision-based measures, where images collected are analyzed with computer vision algorithms to estimate structural components deflections. This vision based approach was demonstrated with 2 different controlled laboratory experiments. In one example, the deflection of a structural beam loaded by 2 hydraulic actuators was first estimated in a quasi static test. In the second example, the same approach was adopted to estimate the deflection of a steel grid (resembling a small scale bridge) subject to dynamic loading induced by a shaker. During testing, the estimated deflections were compared with measured displacements collected using traditional displacement gages and showing excellent agreement and confirming the potential for field applications on full scale structural systems. The main research significance is the validation of algorithms that can automatically analyze video images of targets placed on the structural system of interest and accurately estimate deflection of structures such as girders in bridges during load testing or during operational monitoring (deformation measured while the structure is subject to live loading from traffic).
Tick Microbiome and Borreliaceae Pan-genome Characterization
Authors:   , Socarras Kayla Merced , Ehrlich Garth D.
Published: February 2023

Tick-borne diseases (TBD) have been a blight on human health worldwide despite numerous efforts to advance proper treatment and prevention for this group of maladies. The lack of improvement primarily stems from the paucity of available information on the vectors and TBD pathogens of interest. This extends beyond understanding the basic biology of these parasitic organisms and how to deal with them, it extends on how to identify their impact on the human body. In this dissertation several approaches were taken with the singular focus on how to address the impact and presence of TBD pathogens. First, it is imperative to understand the complete complement of microbes within TBD vectors. Current efforts in this field have been focused on the most wildly known tick species such as Dermacentor variabilis, Amblyomma americanum, and Ixodes scapularis. While these species are a detriment to human safety, so is a rising vector within western North America, Ixodes pacificus. Thus, the first section of this work is dedicated to understanding the bacterial composition of this arachnid ectoparasite. The second segment of this dissertation then focuses on the largest and increasingly prevalent group of obligate pathogens, Borreliaceae spirochetes. These works are the first to develop, construct, and mine the pangenome at the family-level. They are also the first in proposing tangible means of definitively characterizing the spirochetes. Lastly, the final segment of this dissertation is collection of works centered on developing several diagnostic platforms to detect TBD pathogens.
Estimating the Informativeness of the Conditional Autoregressive Model Framework with Applications
Authors:   , Song Guangzi , Quick Harrison S
Published: February 2023

The use of the conditional autoregressive (CAR) model framework of Besag et al. (1991) is ubiquitous in Bayesian disease mapping. While it is understood that Bayesian inference is based on a combination of the information contained in the data and the information contributed by the model, quantifying the contribution of the model relative to the information in the data is often non-trivial. The primary focus of this thesis is to further develop the methodology to measure and control the information contributed by the spatial models. We begin by first introducing the concept of model's informativeness and its application to Poisson distributed data by Quick et al. (2021). Our major objective here is to extend their work by developing a measure of the model's informativeness of Besag et al. (1991) in the case of binomially distributed count data, while also providing a guidance to control the model's informativeness from the framework of Besag et al. (1991). In addition to using our methodology on a data set comprising county-level low weight births in Pennsylvania, stratified by the mothers' race/ethnicity, we also demonstrate the extent to which the excess model's informativeness can overwhelm the information in the data and oversmooth the inferential results. We then reparameterize the CAR model framework of Besag et al. (1991) and propose a new prior specification for the purpose of controlling the model's informativeness in a more straightforward way. After illustrating the use of our methodology on a Poisson distributed data set containing heart disease-related deaths among those aged 35-54 years in 1980 in North Carolina, we show how the method can be implemented to analyze binomially distributed data using the county-level low weight births in Pennsylvania, stratified by mothers' race/ethnicity. Last, we assess the degree of oversmoothing in multiple spatial models for disease mapping via comparing the relative precision of the estimates from each model with those from the CAR model framework of Besag et al. (1991). We believe that users can gain a deeper understanding of the importance of the model's informativeness through these methods. Furthermore, the implications of the model's informativeness - which closely relates to the concept of degree of oversmoothing - to disease mapping are enormous, affecting decisions regarding data collection, prior specifications, data analyses, and policy making.
Incipient Soft-Fault Detection in DC-DC Converters through Switching Observers
Authors:   , Tsinetakes John , Hrebien Leonid , Kam Moshe
Published: February 2023

An observer or state estimator can be programmed into a microcontroller to operate an observer-based fault detection system to detect faults in dc-dc switching converters or other closed loop controlled linear systems. A non-zero difference between the output of the observer and the dc-dc converter can be used to indicate a fault. This difference is defined as an observer residual. The performance of the observer-based fault detection system is dependent on selection of the observer gains. The observer gains are a vector of constants that control the placement of the poles in the differential equations of the observer system model. The location of the poles in the observer model affects the magnitude of the observer residual. A step by step design method to calculate the observer gains and adjust the pole placement of the observer model is presented. The dc-dc observer-based fault detection system is simulated to empirically select observer gains that provide a larger magnitude observer residual. The empirically selected observer gains are used in a microcontroller controlled dc-dc converter with an observer-based fault detection system to demonstrate how the proper selection of the observer gains can produce observer residuals with larger magnitudes, which will more easily detect a fault.
Pengembangan Desain Pembelajaran Multiliterasi Berbasis Tringo dalam Pembelajaran Menulis Teks Eksposisi Siswa SMA
Authors: Nafi'a Muhammad Zidni Ilman , Kuswandi Dedi , Wedi Agus
Published: February 2023

This study aims to develop a tringo-based multiliteracy learning design in learning to write expository texts. The research method used is research and development, while the Dick and Carrey development model is the development model used. In this research and development, it is only limited to the expert validation test stage due to research limitations. The learning device that becomes the output of this learning design is the learning implementation plan (RPP), student worksheet (LKPD), learning e-module, and instructional design usage guide. The results of the development of this learning design were validated by material experts and media experts with the average number of all devices developed obtaining a percentage of 89.76 percent. The validation of material experts for the learning implementation plan obtained 92 percent results, and for student worksheets the results obtained 88 percent, while for the e-learning module the results obtained 89.6 percent. Further validation was carried out by learning media experts for e-learning modules which obtained results of 91.2 percent and for guidelines for the use of learning designs of 88 percent. The results of the validation indicate that the learning design developed is feasible or valid to be used in the learning process.Abstrak: Penelitian ini bertujuan untuk mengembangkan desain pembelajaran multiliterasi berbasis tringo dalam pembelajaran menulis teks eksposisi. Metode penelitian yang digunakan adalah penelitian dan pengembangan, sedangkan model pengembangan Dick and Carrey merupakan model pengembangan yang digunakan. Dalam penelitian dan pengembangan ini hanya dibatasai pada tahap uji validasi ahli dikarenakan keterbatasan penelitian. Perangkat pembelajaran yang menjadi luaran dari desain pembelajaran ini adalah rencana pelaksanaan pembelajaran (RPP), lembar kerja peserta didik (LKPD), e-modul pembelajaran dan panduan penggunaan desain pembelajaran. Hasil pengembangan desain pembelajaran ini divalidasi oleh ahli materi dan ahli media dengan jumlah rata-rata keseluruhan perangkat yang dikembangkan memperoleh hasil presentase sebesar 89,76 persen. Validasi ahli materi untuk rencana pelaksanaan pembelajaran memperoleh hasil sebesar 92 persen, dan untuk lembar kerja peserta didik memperoleh hasil sebesar  88 persen, sedangkan untuk e-modul pembelajaran memperoleh hasil 89,6 persen.  Validasi yang selanjutnya dilakukan oleh ahli media pembelajaran untuk e-modul pembelajaran yang memperoleh hasil sebesar 91,2 persen dan  untuk panduan penggunaan desain pembelajaran sebesar 88 persen. Hasil validasi tersebut menunjukkan bahwa desain pembelajaran yang dikembangkan layak atau valid digunakan dalam proses pembelajaran.
Evaluation of Agronomic Traits and Allele Specific DNA Markers Related to Some Disease and Quality Traits in Mutant Karakılçık M4 Individuals
Authors: YÜCE İlker , DUMLUPINAR Ziya
Published: February 2023

Karakılçık (KK) is a landrace, of which both bread and durum wheat forms exist. This is the first study that reports mutation induction and detection with agronomic traits and allele specific markers on KK durum wheat landrace. In the study, KK landrace was induced with chemical mutation using sodium azide (NaN3) (3 mM) mutagen to improve agronomic traits. In the research, KK genotype and the 13 M4 individuals (KK-1 to KK-13) were used as plant materials. According to the results, the shortest mutant genotype was KK-10 (125.80 cm), with the highest protein ratio (18.50%) and wet gluten ratio (37.10%), while KK-9 genotype had the highest grain yield (4285.6 kg ha-1). The average polymorphism information content (PIC) was calculated as 0.97, while the average allele number was 15.2 per marker. Glu-B1 (Bx7OE primer) allele was determined on KK-11 and KK-13 genotypes. Wx-A1 allele was found on KK-1, KK-2, KK-4, KK-5 and KK-7 genotypes. Sr49 allele (Sun209) was determined on KK-5 genotype, while Yr45 allele (Xwgp118) was detected on KK-10 genotype. In addition, the high protein content allele Gpc-B1 (UHW89 primer) was found on KK-1, KK-2, KK-3 and KK-4 genotypes. Based on the principal component biplot analysis, it was determined that there was a positive relationship between grain yield (GY) with test weight (TW), grain number and weight per spike (GNS and GWS), and negative relationship with the other traits.
¿El Guardián Ciego de la Constitución? El Tribunal Constitucional Colombiano frente a las Políticas Distributivas. Un Problema de Teoría Constitucional, Democrática y de Interpretación Constitucional Democrática
Authors: Rodríguez Valero Luis Alfredo , Leiva Ramírez Eric , Córdova Álvarez Miguel Ángel
Published: February 2023

Las normas que disciplinan al Estado, sobre la conformación de sus órganos y poderes son consideradas normas fundamentales y, por tanto, para algunos teóricos del derecho, merecen una interpretación constitucional especial realizada a través de un control de constitucionalidad democrático. Este control de constitucionalidad especial, debe diferenciarse del tradicional que aplica los métodos clásicos de interpretación. Por lo anterior, el presente texto, a través del estudio de caso del control de constitucionalidad sobre las normas que dieron origen al Presupuesto de Inversión Social Regional en Colombia, reflexionará en torno al control de constitucionalidad democrático de una sociedad pluralista y de intérpretes múltiples. Criticará los principales elementos del fallo y explicará los requisitos que debería tener una verdadera interpretación constitucional democrática más allá de lo señalado por los magistrados que salvaron el voto.
Profile of obstetric patients in intensive care unit -a retrospective study
Authors: Bhavanam Nandini , Munisamaiah Munikrishna , Jayalingegowda Pavithra
Published: February 2023

Background: Obstetric patients form a particular subgroup of population to intensive care admission. Pregnancy specific problems like pre-eclampsia, postpartum haemorrhage or deterioration of pre-existent conditions can be sudden and life threatening, requiring immediate intensive management and monitoring. The main objective was to determine the pattern and outcome of obstetric admissions to intensive care unit.
Methods: It was a retrospective study from June 2020 to June 2022. Obstetric patients admitted to intensive care unit were included in the study. Data were obtained from the patient’s case notes and records from the ICU and were entered into a predesigned proforma.
Results: Maximum study subjects were between age group 21-25 years of age. Most of them were primigravida and admitted in the postpartum period. The most common indications for admission to ICU were preeclampsia with severe features followed by obstetric haemorrhage. The mortality rate was 18.8% and shock attributing to the main cause.
Conclusions: Maternal and child health have become an important measure of human and social development. Early and prompt diagnosis and treatment of high-risk obstetric patients in intensive care unit can prevent and ameliorate serious maternal morbidity.
Assessing the pharmacological and biochemical effects of Salvia hispanica (Chia seed) against oxidized Helianthus annuus (sunflower) oil in selected animals
Authors: Aziz Tariq , Ihsan Fawad , Ali Khan Ayaz , Ur Rahman Shafiq , Zamani Ghazala Yasmin , Alharbi Metab , Alshammari Abdulrahman , Alasmari Abdullah F.
Published: February 2023

Oil oxidation is important in terms of taste, nutritive component quality and toxic effect of the oil. In this study, the oxidized sunflower oil was used along with chia seed in rabbits for the determination of its effects on various hematological and serum biochemical parameters as well as on liver histopathology. Three rabbits were fed with oxidized oil (obtained by heating) at the dose rate of 2 ml/kg body weight by mixing it with green fodder. The other rabbit groups were fed with Chia seed at dose rate of 1, 2 and 3 g/kg along with oxidized sunflower oil. Chia seed was fed alone to three rabbits at the dose rate of 2 g/kg body weight. All rabbits were fed regularly for twenty-one days. For the determination of hematological and biochemical parameters, whole blood and serum samples were collected on different days during feeding period. For histopathology, liver samples were used. Significant changes (p<0.05) were noted in the hematology and biochemical indices in the rabbits that were fed with oxidized sunflower oil alone, and along with different doses of Chia seed. In a dose-dependent manner, all these parameters were significantly improved (p<0.05), when the amount of Chia seed was increased. The biochemical and hematological indices were in normal range in the group fed only with Chia seed. In oxidized oil fed group, liver histopathological analysis showed that cholestasis was present at both sides (bile pigment secretion) and zone 3 necrosis with mild inflammatory cells. Mild vacuolization of hepatocytes was also observed. In Chia seed fed group, hepatocyte vacuolization and mild necrosis was noted. It was concluded that oxidized sunflower oil alters the biochemical and hematological parameters and causes liver abnormalities. Chia seeds act as an antioxidant and retrieve those alterations.
Mechanisms leading to bursting oscillations in the system of predator–prey communities coupled by migrations
Authors:   Institute for Complex Analysis of Regional Problems, Far Eastern Branch, Kurilova Ekaterina , Kulakov Matvej ,   Institute for Complex Analysis of Regional Problems, Far Eastern Branch, Frisman Efim ,   Institute for Complex Analysis of Regional Problems, Far Eastern Branch
Published: February 2023

The purpose is to study the periodic regimes of the dynamics for two non-identical predator– prey communities coupled by migrations, associated with the partial synchronization of fluctuations in the abundance of communities. The combination of fluctuations in neighboring sites leads to the regimes that include both fast bursts (bursting oscillations) and slow oscillations (tonic spiking). These types of activity are characterized by a different ratio of synchronous and non-synchronous dynamics of communities in certain periods of time. In this paper, we describe scenarios of the transition between different types of burst activity. These types of dynamics differ from each other not so much in size, shape, and number of spikes in a burst, but in the order of these bursts relative to the slow-fast cycle. Methods. To study the proposed model, we use the bifurcation analysis methods of dynamic systems, as well as geometric methods based on the division of the full system into fast and slow equations (subsystems). Results. We showed that the dynamics of the first subsystem with a slow-fast limit cycle directly determines the dynamics of the second one with burst activity through a smooth dependence of regime on the number of predators and a non-smooth dependence on the number of prey. We constructed the invariant manifolds on which there are parts of dynamics with tonic (slow manifold) and burst (fast manifold) activity of the full system. Conclusion. We described the scenario for bursting with different waveforms, which are determined by the appearance of the fast invariant manifold and the location of its parts relative to the slow-fast cycle. The transitions between different types of burst are accompanied by a change in the oscillation period, the degree of synchronization, and, as a result, the dynamics becomes quasi-periodic when both communities are not synchronous with each other.