bluuebunny/crossref_metadata_2025 huggingface dataset:
Quand
cogner à plusieurs portes n’entraine pas l’aide espérée aux parents adoptant un enfant
ayant d’importantes difficultés comportementales et relationnelles
Authors: Tremblay Karine , Pagé Geneviève
Published: October 2024

Cadre de la recherche : Les enfants placés en
Banque mixte peuvent présenter d’importantes difficultés comportementales et
relationnelles en raison de leur expérience de négligence/maltraitance dans leur famille
d’origine, ce qui aura des répercussions sur leur fonctionnement relationnel et
comportemental dans leur nouvelle famille. Par conséquent, les parents qui s’en occupent
au quotidien peuvent développer un trauma secondaire ou de filiation.

Objectif : Cet article présente les résultats partiels d’une étude
qualitative, soit ceux concernant les démarches entreprises par les parents adoptifs pour
obtenir de l’aide.

Méthodologie : Dix parents adoptifs
ont été questionnés dans le cadre d’entrevues semi-dirigées sur leur motivation à entamer
un projet d’adoption via le programme Banque mixte, l’arrivée de l’enfant dans leur
famille, les difficultés vécues par l’enfant et leur expérience de trauma secondaire. Les
entrevues ont été transcrites intégralement et soumises à une analyse de
contenu.

Résultats : Après avoir expliqué les
problématiques présentées par leur enfant, cet article détaille les différents services
sollicités par les parents à l’égard des enjeux importants vécus dans leur famille, soit
les services de première ligne, ceux du secteur privé, de l’urgence sociale, de la police
et de la direction de la protection de la jeunesse (DPJ). Enfin, la place qu’occupe l’aide
pour soi-même face à l’importante souffrance vécue par les parents adoptifs est
détaillée.

Conclusion : Bien que l’expérience de
traumas secondaires et de filiation ne concerne pas toutes les familles qui adoptent en
Banque mixte, il importe de soutenir adéquatement celles dont c’est le vécu pour éviter le
placement de l’enfant ou le désengagement des parents.

Contribution : Cet article souligne l’importance d’instaurer une formation uniforme
et pérenne pour les postulants Banque mixte, du soutien aux parents adoptifs et de les
former à la prévention des comportements agressifs chez leur enfant.
Masculinité et paternité en contexte
migratoire : étude des effets de la masculinité sur la construction de l’identité
paternelle de nouveaux immigrants au Québec de différentes origines culturelles
Authors: Bergheul Saïd , Bationo Nebila Jean-Claude , Konan Tano Hubert , Ramdé Jean , Godin Jessica
Published: October 2024

Cadre de recherche : L’immigration dans des
contextes comme celui du Canada et du Québec est susceptible d’engendrer des changements
dans les fonctions masculines. Ainsi, les pères immigrants, selon leurs origines et
profils, négocient et présentent différentes facettes de la masculinité pour s’adapter aux
diverses réalités du pays d’accueil.

Objectifs : Cet
article s’intéresse à l’impact de l’immigration sur la masculinité et l’identité
paternelle de pères immigrants de différentes origines au Québec.

Méthodologie : Nous avons réalisé au total 39 entretiens avec des
pères immigrants d’origine subsaharienne, maghrébine, européenne, asiatique et
latino-américaine. Un guide d’entretien, avec des questions ouvertes, leur a permis de
s’exprimer sur leur perception de la paternité, leur identité, leur engagement paternel et
leur adaptation en contexte migratoire.

Résultats : Nos
résultats indiquent que la paternité constitue une occasion de validation de la
masculinité chez ces hommes. Par ailleurs, le rôle de pourvoyeur représente une
expression, une valorisation et un renforcement de leur masculinité. Nous avons également
constaté chez les pères immigrants une évolution de la perception et une redéfinition de
la masculinité à travers l’engagement paternel afin de surmonter les difficultés
d’intégration dans le pays d’accueil.

Conclusion : Cet
article montre qu’au-delà des difficultés, l’immigration constitue une opportunité
d’engagement et de redéfinition de la paternité et de la masculinité pour plusieurs hommes
immigrants.

Contribution : Les différentes observations
issues de cette étude montrent la nécessité de tenir compte de la masculinité dans la
prise en charge et dans l’élaboration des programmes destinés aux pères immigrants. Enfin,
l’article ouvre des pistes de recherche pour mieux comprendre différents types de
paternité.
El ‘show’ viral de las presidenciales: cómo las redes sociales están redefiniendo la política de EEUU
Authors: Pellicer i Alapont Miquel
Published: October 2024

Las elecciones presidenciales entre Harris y Trump han trascendido los mítines y debates televisivos. Las redes sociales son la nueva arena, donde la viralidad, la inteligencia artificial (IA) y los influenciadores dominan el juego.
SOCIO-DEMOGRAPHIC CHARACTERISTICS AS A FACTOR OF STUDENT LOYALTY: A MARKETING APPROACH
Authors: Macura Perica , Elez Nedeljka
Published: October 2024

This paper focuses on student loyalty in higher education. In higher education, loyalty primarily means building a stronger connection with students, shaping a positive perception, and spreading positive publicity about the institution. Loyalty in higher education also involves retaining students until the completion of their studies and maintaining the relationship through enrollment in subsequent study cycles or alumni organizations. Building relationships with students and adopting a student-oriented approach will strengthen the bond with them and provide the foundation for building their loyalty. This paper analyzes the relationship between socio-demographic characteristics (gender and socio-economic status) and status characteristics of students (years of study, whether they pay for their studies or not, whether they are domestic or foreign students) with dimensions of student loyalty (satisfaction with the service, intention to stay at the institution, and attachment). The research has shown that gender and socio-economic status of students do not have a significant impact on any dimension of loyalty. On the other hand, the analysis results indicate that factors which are related to student status significantly influence all dimensions of student loyalty to the institution. The research results in this paper imply that marketing approaches in higher education can enhance relationships with students, their loyalty, and assist the management of these institutions in making decisions that will impact student retention at the educational institution.
Hydrochemical Assessment of Groundwater in Ludhiana and Amritsar Districts of Punjab and Identification of Fluoride Hotspots using GIS
Authors: Khusulio Kaikho , Sharma Neeta Raj , Kumar Rohan , Das Iswar Chandra , Setia Raj
Published: October 2024

High fluoride concentrations in soil, water, or air can pose serious environmental and health risks to plants, and animals. Along with other hydrochemical parameters, this study investigates fluoride concentrations in the groundwater in the Ludhiana and Amritsar districts of Punjab, India. A total of 222 water samples were uniformly collected at approximately five-kilometer intervals for hydrochemical analyses. Statistical methods such as inverse distance weighting (IDW) and correlation matrices were used to assess the fluoride distribution and its relationships with other parameters. According to WHO guidelines, most fluoride concentrations were below 0.6 ppm in Ludhiana (84.30%) and Amritsar (77.23%). Fluoride levels that were within the permissible range (0.6–1.5 ppm) were found in 15.70% of Ludhiana’s samples and 21.78% of Amritsar’s samples; only 1% of Amritsar’s samples exceeded the permissible limit (>1.5 ppm). The water quality index (WQI) analysis indicated that0.83% of the groundwater samples from the Ludhiana district and 4.95% from the Amritsar district were unfit for consumption. This study demonstrates the importance of standardized sample collection and the use of GIS technology for comprehensive hydrochemical assessments, raising awareness and reducing health risks.
Variability and Correlation among SST, Chlorophyll-a Levels, ENSO, and Pelagic Fishing in Southern Part of Madura Strait, Indonesia, Based on Landsat 9 OLI/TIRS Imagery
Authors: Elian Taffy , Setiawan Naufal
Published: October 2024

Indonesia’s marine resources are abundant, with fishing being a primary focus. The effective management of these resources requires an understanding of the factors that influence them, such as sea surface temperature (SST), El Niño-Southern Oscillation (ENSO) as indicated by the Southern Oscillation Index (SOI), and chlorophyll-a levels as food sources. This research aimed to elucidate the relationships among those factors at Madura Strait by utilizing their characteristics in response to the electromagnetic wavelengths that can be found Landsat 9 OLI/TIRS satellite images.This research utilized the satellite’s Thermal Infrared Sensor (or Band 10) (10.6–11.19 µm) to obtain the SST levels as well as the OceanColor 2 (OC2) algorithm to process Band 2 (0.45–0.51 µm) and Band 3 (0.53–0.59 µm) in order to obtain the chlorophyll-a levels. The results were the mean values of the SST (21.42 and 20.60°C) and the chlorophyll-a levels (0.77 and 0.87 mg/m3) from the periods of June through August 2022 and December 2022 through February 2023, respectively. Furthermore, a correlation test and t-test were conducted, which indicated that the chlorophyll-a levels were contradictory with the SST, SOI, and total pelagic fish catches (which were in alignment). The t-test results only indicated significant correlations between the SST and chlorophyll-a levels (–0.806) and between the SST and SOI (0.732), while the other correlation was not significant.
Methodology for Study of Rockfalls in Urban Areas – Computer Modeling and Mitigation in Algodonales, Spain
Authors: Pardo Juan Manuel , Galera Jose Miguel , Mulas Joaquin
Published: October 2024

Rockfalls in urban areas can cause significant damage. Without direct observation, it is difficult to reconstruct the specific details of an event. The study of rockfalls requires analyses of the source areas, slope parameters, blocks characteristics (size, shape, and mass), and the likely movements of independent blocks along their trajectories (free-falling, rolling, sliding, and rebounding). This article will propose a feasible methodology for the study of rockfalls based on identifiable parameters, conditioning factors (geology, geomorphology, geomechanical, hydrogeology, climate, and biology), and triggering factors (climate and dynamic loads). This article proposes the use of modeling programs to facilitate rockfall research and data management. The study of conditioning factors allows researchers to state several coefficients (restitution, surface roughness, rolling resistance, and friction) that one inputs into a modeling program, allowing researchers to obtain the representative results that are needed to design effective remedial measures. The methodology has been successfully applied to the urban area of Algodonales (Province of Cádiz, Spain).
The zinc transporter Slc30a1 (ZnT1) in macrophages plays a protective role against attenuated Salmonella
Authors: Na-Phatthalung Pinanong , Sun Shumin , Xie Enjun , Wang Jia , Min Junxia , Wang Fudi
Published: October 2024

The zinc transporter Slc30a1 plays an essential role in maintaining cellular zinc homeostasis. Despite this, its functional role in macrophages remains largely unknown. Here, we examine the function of Slc30a1 in host defense using mice models infected with an attenuated stain of Salmonella enterica Typhimurium and primary macrophages infected with the attenuated Salmonella. Bulk transcriptome sequencing in primary macrophages identifies Slc30a1 as a candidate in response to Salmonella infection. Whole-mount immunofluorescence and confocal microscopy imaging of primary macrophage and spleen from Salmonella-infected Slc30a1flag-EGFP mice demonstrate Slc30a1 expression is increased in infected macrophages with localization at the plasma membrane and in the cytosol. Lyz2-Cre-driven Slc30a1 conditional knockout mice (Slc30a1fl/fl;Lyz2-Cre) exhibit increased susceptibility to Salmonella infection compared to control littermates. We demonstrate that Slc30a1-deficient macrophages are defective in intracellular killing, which correlated with reduced activation of nuclear factor kappa B and reduction in nitric oxide (NO) production. Notably, the model exhibits intracellular zinc accumulation, demonstrating that Slc30a1 is required for zinc export. We thus conclude that zinc export enables the efficient NO-mediated antibacterial activity of macrophages to control invading Salmonella.
A Novel Mouse Model for LAMA2-Related Muscular Dystrophy: Analysis of Molecular Pathogenesis and Clinical Phenotype
Authors: Tan Dandan , Liu Yidan , Luo Huaxia , Shen Qiang , Long Xingbo , Xu Luzheng , Liu Jieyu , Zhong Nanbert , Zhang Hong , Xiong Hui
Published: October 2024

Our understanding of the molecular pathogenesis of
LAMA2
-related muscular dystrophy (
LAMA2
-MD) requires improving. Here, we report the phenotype, neuropathology and transcriptomics data (scRNA-seq and bulk RNA-seq) of a new
Lama2
knockout mouse (dy
H
/dy
H
) which was created based on the human
LAMA2
-MD mutation hotspot region using CRISPR-Cas9. The dy
H
/dy
H
mice presented severe phenotype with muscular dystrophy. Mouse brain scRNA-seq showed that
Lama2
gene was expressed predominantly and specifically in vascular and leptomeningeal fibroblasts and vascular smooth muscle cells, and weakly in astrocytes in wild-type mouse. Laminin α2 expression on the cortical surface was observed with immunofluorescence. In dy
H
/dy
H
,
Lama2
expression is decreased in those cell types, which might be associated with the disruption of gliovascular basal lamina assembly. Additionally, transcriptomic investigation of muscles showed 2020 differentially expressed genes which are mainly associated with the impaired muscle cytoskeleton and development. In summary, this study provided useful information for understanding the molecular pathogenesis of
LAMA2
-MD.
The NeuroML ecosystem for standardized multi-scale modeling in neuroscience
Authors: Sinha Ankur , Gleeson Padraig , Marin Bóris , Dura-Bernal Salvador , Panagiotou Sotirios , Crook Sharon , Cantarelli Matteo , Cannon Robert C , Davison Andrew P , Gurnani Harsha , Silver R Angus
Published: October 2024

Data-driven models of neurons and circuits are important for understanding how the properties of membrane conductances, synapses, dendrites and the anatomical connectivity between neurons generate the complex dynamical behaviors of brain circuits in health and disease. However, the inherent complexity of these biological processes make the construction and reuse of biologically detailed models challenging. A wide range of tools have been developed to aid their construction and simulation, but differences in design and internal representation act as technical barriers to those who wish to use data-driven models in their research workflows. NeuroML, a model description language for computational neuroscience, was developed to address this fragmentation in modeling tools. Since its inception, NeuroML has evolved into a mature community standard that encompasses a wide range of model types and approaches in computational neuroscience. It has enabled the development of a large ecosystem of interoperable open source software tools for the creation, visualization, validation and simulation of data-driven models. Here, we describe how the NeuroML ecosystem can be incorporated into research workflows to simplify the construction, testing and analysis of standardized models of neural systems, and supports the FAIR (Findability, Accessibility, Interoperability, and Reusability) principles, thus promoting open, transparent and reproducible science.
Neurons enhance blood–brain barrier function via upregulating claudin-5 and VE-cadherin expression due to glial cell line-derived neurotrophic factor secretion
Authors: Yang Lu , Lin Zijin , Mu Ruijing , Wu Wenhan , Zhi Hao , Liu Xiaodong , Yang Hanyu , Liu Li
Published: October 2024

Blood–brain barrier (BBB) prevents neurotoxins from entering central nervous system. We aimed to establish and characterize an in vitro triple co-culture BBB model consisting of brain endothelial cells hCMEC/D3, astrocytoma U251 cells, and neuroblastoma SH-SY5Y cells. Co-culture of SH-SY5Y and U251 cells markedly enhanced claudin-5 and VE-cadherin expression in hCMEC/D3 cells, accompanied by increased transendothelial electrical resistance and decreased permeability. Conditioned medium (CM) from SH-SY5Y cells (S-CM), U251 cells (U-CM), and co-culture of SH-SY5Y and U251 cells (US-CM) also promoted claudin-5 and VE-cadherin expression. Glial cell line-derived neurotrophic factor (GDNF) levels in S-CM and US-CM were significantly higher than CMs from hCMEC/D3 and U-CM. Both GDNF and US-CM upregulated claudin-5 and VE-cadherin expression, which were attenuated by anti-GDNF antibody and GDNF signaling inhibitors. GDNF increased claudin-5 expression via the PI3K/AKT/FOXO1 and MAPK/ERK pathways. Meanwhile, GDNF promoted VE-cadherin expression by activating PI3K/AKT/ETS1 and MAPK/ERK/ETS1 signaling. The roles of GDNF in BBB integrity were validated using brain-specific Gdnf silencing mice. The developed triple co-culture BBB model was successfully applied to predict BBB permeability. In conclusion, neurons enhance BBB integrity by upregulating claudin-5 and VE-cadherin expression through GDNF secretion and established triple co-culture BBB model may be used to predict drugs’ BBB permeability.
Elucidating ATP’s role as solubilizer of biomolecular aggregate
Authors: Sarkar Susmita , Gupta Saurabh , Mahato Chiranjit , Das Dibyendu , Mondal Jagannath
Published: October 2024

Proteins occurring in significantly high concentrations in cellular environments (over 100 mg/ml) and functioning in crowded cytoplasm, often face the prodigious challenges of aggregation which are the pathological hallmark of aging and are critically responsible for a wide spectrum of rising human diseases. Here, we combine a joint-venture of complementary wet-lab experiment and molecular simulation to discern the potential ability of adenosine triphosphate (ATP) as solubilizer of protein aggregates. We show that ATP prevents both condensation of aggregation-prone intrinsically disordered protein Aβ40 and promotes dissolution of preformed aggregates. Computer simulation links ATP’s solubilizing role to its ability to modulate protein’s structural plasticity by unwinding protein conformation. We show that ATP is positioned as a superior biological solubilizer of protein aggregates over traditional chemical hydrotropes, potentially holding promises in therapeutic interventions in protein-aggregation-related diseases. Going beyond its conventional activity as energy currency, the amphiphilic nature of ATP enables its protein-specific interaction that would enhance ATP’s efficiency in cellular processes.
Impact of three weeks of integrative neuromuscular training on the athletic performance of elite female boxers
Authors: Niu Zhen , Huang Zijing , Zhao Gan , Chen Chao
Published: October 2024

Objectives

To investigate the effects of integrative neuromuscular training (INT) on the athletic performance of elite female boxers.

Methods

A before-and-after controlled experiment was conducted on 37 elite Chinese female boxers (Age: 26.00 ± 3.11 years). All included athletes have competed at the international level. The INT intervention was administered 11 times per week for 3 weeks. This training includes strength training, explosive training, core stability, agility exercises, high intensity intervals and sprint intervals. Basic physical fitness tests, including the deep squat and bench press one-repetition maximum (1RM), vertical long jump, 30 m sprint run, 400 m run, 3,000 m run, 1-minute hexagonal jump, and 3-minute double shake; as well as specialized striking ability tests, including single-punch striking and 10-second, 30-second, and 3-minute continuous punching, were conducted before and after the intervention.

Results

Compared with pre-intervention baseline data, significant differences were found in the athletes’ post-intervention baseline physical fitness, including squat and beach press (1RM), vertical jump, 30 m sprint run, 400 m run, 3,000 m run, 1-minute hexagonal jump, and 3-minute double shake (p < 0.05). Additionally, 10-second, 30-second, and 3-minute continuous punching were significantly different compared with pre-intervention (p < 0.05). However, no significant differences were found in single punch power (p > 0.05).

Conclusion

The 3-week INT can significantly improve the maximum strength, vertical explosive power, linear acceleration, agility, and continuous punching abilities of Chinese elite female boxers. The use of INT in physical training may enhance their athletic performance.
Kinematic differences between female national and provincial athletes in the tennis serve
Authors: Chen Yan , Wang Tianyang , Zhao Yuyan , Zhan Genghao , Tang Yinchao , Wang Zefeng
Published: October 2024

Background

Tennis, the second-largest ball game in the world, has a particularly wide audience. To date, little research has been conducted on the biomechanics of female serves.

Purpose

The purpose of this study was to capture the key moments by using 1,000 frames/s high-speed video analysis, to analyze the kinematics of the serving techniques of national athletes and provincial athletes, to determine the differences between the two levels of athletes, and to provide theoretical references for the improvement of scientific training level.

Methods

Ten female athletes were selected as participants for this study, five of whom are national athletes, and the other are provincial athletes. Three-dimensional filming techniques were employed to capture videos of the first and second serve techniques. Simi Motion was applied to obtain the 3D kinematic data. Statistical analyses were performed using IBM SPSS Statistics 27.0, and Mann–Whitney U tests were conducted to determine differences between groups.

Results

Significant differences in kinematics were found between national and provincial athletes. At the moment of the left knee’s minimum flexion (T2), in the first serve, national athletes had a smaller shoulder-hip vertical plane angle (−18.281 ± 6.142° vs. −25.631 ± 3.497°; p = 0.047) and a larger hip vertical plane rotation angle (−9.378 ± 4.263° vs. −0.470 ± 4.724°; p = 0.047). In the second serve, national athletes had a smaller hip horizontal plane rotation angle (−1.720 ± 4.683° vs. 24.146 ± 24.014°; p = 0.047) but a larger hip vertical plane rotation angle (−11.553 ± 1.949° vs. −0.422 ± 4.958°; p = 0.009). At the moment of impact (T4), in the second serve, national athletes’ batting position (0.296 ± 0.088 m vs. 0.446 ± 0.094 m; p = 0.047) was further back. Additionally, in the second serve, national athletes consistently had their body center of gravity further back at T2 (−0.106 ± 0.052 m vs. −0.018 ± 0.048 m; p = 0.028), T3 (0.002 ± 0.038 m vs. 0.132 ± 0.039 m; p = 0.009), and T4 (0.073 ± 0.050 m vs. 0.217 ± 0.034 m; p = 0.009).

Conclusions

The results of this study indicated several significant kinematic differences between national and provincial athletes, these variations were noted in the shoulder, hip, and body center of gravity. In summary, for the overall first and second serves, it is recommended that national athletes increase the horizontal plane angle of the shoulders and hips at T2, whereas provincial athletes decrease the horizontal plane angle of the shoulder–hip. In addition, provincial athletes need to increase the vertical plane angle of the hip joint, so that the top of the hip can be increased more, and provincial athletes need to be careful not to have the center of gravity too far in front of the body at T2, T3, and T4, so that it can hit the ball at a higher position to increase the swing speed.
The Interconnectedness of Earnings Management, Corporate Governance Failures, and Global Economic Stability: A Critical Examination of the Impact of Earnings Manipulation on Financial Crises and Investor Trust in Global Markets
Authors: Alao Adegbenga Ismaila , Adebiyi Olubukola Omolara , Olaniyi Oluwaseun Oladeji
Published: October 2024

This study critically examines the interconnectedness of earnings management, corporate governance failures, and their impact on global economic stability and investor trust. Focusing on the Enron (1993–1995) and Wirecard (2015–2019) scandals, the research identifies key financial and governance indicators that contributed to these collapses, including CEO duality, weak board oversight, and manipulated financial reporting. Data for the analysis were drawn from corporate financial reports, macroeconomic indicators sourced from the World Bank, and stock market data from MarketWatch. Financial ratio assessments and regression models reveal a statistically significant negative relationship between GDP growth and abnormal returns for Enron (p = 0.014), while inflation had a strong positive impact on abnormal returns in both cases (p < 0.001). Time series analysis was applied to assess the macroeconomic consequences of corporate collapses on global financial markets. The findings demonstrate how declining GDP growth and rising inflation amplify market responses to governance failures. Recommendations include enhancing corporate governance frameworks, intensifying regulatory enforcement, and fostering global regulatory cooperation to safeguard financial markets and restore investor trust.
Carbon Sequestration in a Changing Climate: Management Techniques and Strategic Solutions
Authors: Dasgupta Kushal , Mahanty Atanu
Published: October 2024

Carbon sequestration in agriculture plays a critical role in mitigating climate change by capturing and storing atmospheric carbon dioxide (CO2) in soil and biomass. This process involves various strategies and management practices aimed at enhancing soil organic carbon (SOC) levels while maintaining or improving agricultural productivity. Key strategies include no-tillage or reduced tillage, which minimizes soil disturbance and promotes residue retention, thus slowing down decomposition and enhancing carbon storage. Crop rotation and the use of cover crops further contribute to carbon sequestration by diversifying root structures and improving soil health. Organic farming practices, such as applying farmyard manure and compost, provide essential organic matter that enriches soil quality and increases carbon retention. Additionally, the incorporation of deep-rooted plants and biochar enhances carbon storage in deeper soil layers, making them more resilient to climate variability. The integration of these practices not only sequesters carbon but also improves soil fertility, water retention, and overall ecosystem health.
Effective management of carbon sequestration in agricultural systems requires a holistic approach that considers local conditions, crop diversity, and sustainable land use practices. By adopting these strategies, agriculture can become a significant carbon sink, contributing to global efforts to reduce atmospheric CO2 concentrations while ensuring food security and environmental sustainability.
Enumeration of Genetic Variability Parameters and Association among Early Seedling Growth Parameters under Polyethylene Glycol (PEG) induced Osmotic Stress in rabi Sorghum (Sorghum bicolor (l.) Moench)
Authors: R Karthik , Hanamaratti N. G.
Published: October 2024

Aims: The research aims to explore the variability within diverse rabi sorghum germplasms and identify the relationships among different early seedling growth traits. This will provide valuable insights for future breeding programs, aiding in the development of resilient sorghum varieties that can contribute to improved food security and agricultural sustainability.
Study Design: The study was conducted by employing factorial complete randomized design (FCRD) with two replications. Where, two factors was considered, genotype as first factor and PEG concentration as second.
Place and Duration of Study: The experiment was conducted during rabi season of 2023 at University of Agricultural Sciences Dharwad, Karnataka.
Methodology: A total of 156 germplasm lines of rabi sorghum were assessed in vitro for early seedling growth characteristics, including germination percentage, shoot length, root length, seedling dry weight, and seedling vigor indices I and II, under both control and osmotic stress conditions induced by polyethylene glycol (PEG). Osmotic stress was induced by dissolving PEG 6000 in distilled water to achieve the desired concentration. The germplasm lines were then subjected to germination and early growth under these conditions using the paper towel method. The genetic variability parameters for each trait were quantified to examine the degree of variability in the material used, and correlation analysis was performed to understand the relationships among the traits studied.
Results: The variance analysis showed highly significant differences among genotypes, treatments, and the genotype-by-environment (G×E) interactions. Genetic variability parameters revealed considerable variability across all traits studied, which tended to increase with higher stress levels. Moderate to high GCV and PCV was observed for all the traits studied. Correlation analysis demonstrated a strong, significant positive relationship among all seedling parameters, except between root length and shoot length, as well as between shoot length and germination percentage under control conditions.
Conclusion: The study emphasizes the effect of osmotic stress on the early vigor and growth of sorghum seedlings. The findings reveal significant variability in seedling traits, suggesting that selection can be employed for genetic enhancement of these traits. Correlation analysis identified specific traits or combinations of traits that should be considered when selecting genotypes tolerant to osmotic stress conditions. These findings offer great potential to guide and improve selection and breeding programs focused on enhancing drought tolerant sorghum varieties.
Advances in Triticale (X Triticosecale) Improvement: Chromosome Manipulation and Biotechnological Approaches
Authors: Subedi Mamata , Sandal Sanjeet Singh , Savindra Patil kulbhushan , Paudel Pratikshya , Walia Puneet , Gopera Shubham , Mane Omkar Prakash
Published: October 2024

Triticale (X Triticosecale) is a hybrid cereal crop with great potential for enhancing food security. It is a synthetic cereal. Meanwhile, certain genetic instabilities arising from the merging of the rye and wheat genomes have impeded the advancement of triticale, chromosome engineering advancements along with biotechnological approaches might potentially unleash the full potential of triticale. This article provides a comprehensive summary of the historical development and current status of research on conventional and molecular breeding and  manipulating triticale chromosomes in order to introduce beneficial traits, correct genetic abnormalities, and accelerate breeding. Among the major strategies covered are chromosomal doubling, addition, replacement, translocation, and deletion. Beneficial genes from rye for quality of grain, yield, and disease resistance were incorporated into triticale backgrounds using addition and replacement lines. In general, using chromosome-modifying technologies within an integrated breeding framework may help with genetic stabilization, the planned evolution of triticale for greater productivity and robustness, and strategic trait integration. This study looks at the advantages, disadvantages, and potential benefits of using chromosomal engineering to enhance triticales.
Wave Height Estimation with a Short Return Period
Authors: Cho Hong-Yeon , Che Min-Ji , Lee Gi-Seop
Published: October 2024

Bisection and grid search methods are proposed as wave height estimation techniques for short return periods (hereafter RP; reference, one year) using long-term wave monitoring data. The proposed method is compared and evaluated with the estimation results using GP (generalized Pareto) and GEV (generalized extreme value) distribution functions, which are widely used as extreme value analysis methods. The wave height data used for the estimation were KMA Ulleungdo Ocean Buoy’s wave height data observed for 12 years from 2012 to 2023. The estimation results show that the annual frequency wave height is 4.55 m, the 90% confidence interval (±5%) is [4.18, 4.69] (m), and the confidence interval for the RP is [0.58, 1.42] (years). The difference from the GP and GEV estimation results (4.61 m and 4.53 m, respectively) was statistically ‘no significance difference.’ The method proposed in this study can estimate design variables for RPs without assumptions on candidate extreme distribution functions or parameter estimation procedures, so it can be used to estimate wave heights for short RPs of one year or less when observation data of approximately ten years or more are available.
Assessment Of Neuroradiological Features Of Wolfram Syndrome
Authors: Rathod Dr Tukaram , Sultanpuri Dr Chetana , Bhattacharyya Dr Shreyashi
Published: October 2024

The WOLFRAM syndrome is a rare hereditary neurodegenerative disorder described for the first time in 1938 as the coexistence of a diabetes mellitus and optic atrophy to which join frequently a diabetes insipidus and a bilateral deafness. Here we report cranial MRI findings in a 20 year old patient who presented with diabetes mellitus, decreased visual loss since 3 years with progressive loss of hearing since 6 months. We reviewed the brain MR images to determine the frequency and characteristics of common neuroradiologic findings. Imaging findings include absence of the normal high signal of the neurohypophysis, atrophy of visual pathways, the brainstem, cerebellum and cerebral cortex and abnormal signal changes in pons
Giant Lobular Fibrous Epulis- A Case Report
Authors: Dhusia Dr. Archana H , Dhusia Dr. Hemant
Published: October 2024

The Fibrous epulis, is a tumour like lesion arising from the gingiva, periosteum or periodontal ligament and is commonly involving the interdental papilla. Its etiology is attributed to a reactive mechanism in response to chronic irritation or tissue injury which stimulates excessive tissue response. They are usually asymptomatic and have a very slow rate of growth. The recurrence rate is high and they are commonly treated by a combination of surgical excision, thorough curettage and oral prophylaxis. We report a case of a Giant lobular fibrous epulis in a 62 year old female which was located in the left maxillary canine, first premolar region since 6 months. It was asymptomatic and was pale pink in colour and pedunculated and lobular with no involvement of the underlying bone. It was surgically excised along with thorough curettage and oral prophylaxis. The histopathology report was suggestive of fibrous epulis.
Assessment Of Nutritional Status Of Under Five Children In Sokoto North Local Government Area, Sokoto State
Authors: I.J Nkwoka , A. A Muniru
Published: October 2024

Background: Malnutrion is an imbalance between the intake of calorie and the body’s requirement. When the body’s requirement supersedes the intake, it is under nutrition and when the intake is more than the body’s requirement, it leads to overweight or obesity. Both instances are forms of malnutrition. The study aim to determine prevalence of under nutrition among the study subject , age variation in relation to under nutrition and compare results of malnutrition obtained from Mid-Upper-Arm circumference and other methods of determining Nutritional status (weight-for-Age and height-for-Age Materials and Methods: a descriptive cross-sectional study was conducted among 112 under five children in Sokoto North LGA. Multi stage sampling technique was used for selection where 3 districts were randomly selected from the 11 districts in Sokoto North LGA, and 4 areas where the study was carried out were randomly selected from the 3 districts. Results: The prevalence of stunting was 53.6% among which 22.3% were mildly stunted , 15.3% were moderately stunted, and 16.1% were severely stunted. The prevalence of wasting was 53.6% of which 14.28% had Grade 1 wasting, 9.8% of the subjects were moderately wasted (grade 2), 12.5% were severely wasted(grade3) and 17% had very severe wasting. Majority of the children (80.4%) had suffered from one form of illness or the other. Mean of under 5 years Feeding practices showed that 98.2% were breastfed, 12.9% of those who breastfed were stopped abruptly, majority of the study subject were introduced to complementary feeding at 6 months of age (50.9%) and majority (79.4%) have received one form of immunization or the other. Determinants of malnutrition were maternal level of education, time of introduction of complementary feeding as well as the type, frequency and quality of food introduced, childhood illness, immunization status, parents’ occupation among others. Conclusion: The results showed that there is high prevalence of malnutrition among under-five children in Sokoto North Local Government Area of Sokoto State We recommended that mothers should be educated and encourage for exclusive breastfeeding
Case Report: Steven Johnson Syndrome (SIS) Induced By Antibiotics: A Detailed Analysis
Authors: Aneesa Shaik , Sri Kurra Medhani , Tejaswini Marpu , Ravisankar Panchumarthy , Babu P Srinivasa
Published: October 2024

Background: Stevens-Johnson Syndrome SJS is a rare but very serious mucocutaneous disease primarily caused by medications that includes antibiotics. This case report is about a 35-year-old male who suffered from SJS due to treatment for urinary tract infection using co-trimoxazole. Case Presentation: The patient began with symptoms of flu, later on followed by rapid progression of erythematous rash and painful mucosal involvement. On clinical examination, there were blisters, skin detachment involving 10% of the body surface area, and oral and ocular mucosal lesions. This reaction developed in a temporal association with co-trimoxazole therapy, making the drug a likely cause. She was systemically treated with corticosteroids and supportive care and showed marked recovery in two weeks from hospitalization. Conclusion: This case underlines the importance of early suspicion of SJS in patients receiving antibiotic treatment. Removal of the offending drug and timely initiation of multi-disciplinary management will only improve the outcome in such patients.
Navigating Hysterectomy Choices: A Retrospective Study On Non-Descent Vaginal And Total Abdominal Hysterectomy In Rural Women
Authors: Devi Uma , I N Bindu , K Harrini , Siva Aiswarya , . Fasna , Hameed Jamila
Published: October 2024

Background The aim of the study is to compare the results of non-descent vaginal and total abdominal hysterectomy procedures done in women in a tertiary care hospital. A retrospective study done by collecting the data from medical records who underwent non-descent vaginal and total abdominal hysterectomy done in women with fibroids, adenomyosis, endometrial atypical hyperplasia and abnormal uterine bleeding. Materials and Methodology This was a retrospective study done by collecting the data from medical record department of the hospital for the period of 6 months from April 2024 to September 2024. The total record of the study consisted of 400 patients out of which 200 patients underwent total abdominal hysterectomy and the rest 200 underwent non-descent vaginal hysterectomy. Those patients were pre-operatively assessed by physical, clinical, radiological evaluations as well as biochemical tests. Results The data of a total of 200 NDVH patients and 200 TAH patients was analysed which showed that NDVH patients had lower parity and BMI, smaller uterine sizes, and were more likely to have surgery for abnormal uterine bleeding. Intraoperative outcome was found to be better for NDVH, with less blood loss and shorter operative duration. The post-operative complications were significantly lower in the NDVH group, resulting in shorter hospital stays. Overall, NDVH outcomes were found to be superior to TAH. Conclusion: The non-descent vaginal hysterectomy has much advantages when compared to total abdominal hysterectomy
Incidence Of Insomnia, Anxiety, Depression, Overweight And Drug And Alcohol Use Among Medical Students
Authors: Souza Ana Clara Pavaneli R. De , Ponsoni Leonardo Alexandre , Silva Aline Cristina Couto Da , Muniz Isadora Rossi , Bellucci Ana Luiza Trindade , Bezerra Thiago Augusto Rochetti
Published: October 2024

Introduction: The existence of a toxicity in medical culture caused by chronified stress in the exercise of the profession by demanding excellence in practice and the adoption of infallible knowledge. As a result, doctors and medical students have shown higher rates of psychological distress, burnout and diagnosed mental illness. Methodology: A questionnaire consisting of 11 questions about sleep quality, depression, anxiety, diet and exercise was carried out among medical students. A total of 83 medical students from 7 different Brazilian educational institutions answered the questionnaire. Objective: To Carry out a descriptive of a quantitative nature and exploratory research through a structured and pre-planned questionnaire with questions regarding the quality of sleep, anxiety, diet, depression, alcohol and drug consumption by medical students, in different periods of training.
Prevalence And Severity Of High Blood Pressure In Morocco
Authors: Boufars Amina , Hami Hind , Idrissi Karim Sbai , Kafssaoui Sanae El
Published: October 2024

Background: Hypertension, also known as high blood pressure (HBP), is a chronic medical condition characterized by persistently elevated blood pressure in the arteries. Although it may not always exhibit noticeable symptoms, hypertension can lead to serious long-term health complications, including an increased risk for coronary artery disease, stroke, heart failure, atrial fibrillation, peripheral vascular disease, vision loss, chronic kidney disease, and dementia. The objective of this study is to determine the prevalence and severity of hypertension among patients in Rabat, Morocco. Methods: This is a retrospective descriptive study that included all patients diagnosed with hypertension at the Military Hospital Mohammed V of Rabat (Morocco), during the period between 2004 and 2018. A standardized questionnaire was completed for each patient. Prior to data collection, patients were informed about the objectives of the study, and measures were taken to protect their confidentiality and anonymity. The study parameters included age, gender, time elapsed since hypertension diagnosis, and hypertension severity. Results: A total of 10,929 individuals were included in the study, with half being male. The mean age of the patients was 71 ± 17 years. The age group most affected was those aged 65 years or older, representing 62% of all groups. Of the hypertensive cases, 70% were classified as moderate hypertension. Furthermore, hypertension significantly increased with age (p˂0.001). Conclusion: Adopting positive lifestyle changes and adhering to prescribed medications are key strategies that can effectively lower blood pressure and reduce the risks of severe health complications commonly associated with hypertension. Examples of effective lifestyle changes include weight loss, regular physical exercise, reduced salt and alcohol consumption, and a healthy diet. Medications for managing hypertension may also be necessary in some cases.
In Vitro Evaluation Of Surface Roughness Of Three Class V Restorative Materials Following Prophylactic Instrumentation
Authors: S Anugraha , Hariharan Madhu , Muliyar Sabir , Pius Alen , Raj Sheena
Published: October 2024

Objective: This study was designed to determine which among the three Class V restorative materials - Omnichroma, GC Gold label Hybrid and Beautifil exhibits the least increase in surface roughness when subjected to manual or ultrasonic prophylactic instrumentation. Materials and methods: Class V cavity preparation were performed on 60 mandibular premolar teeth and randomly divided into 3 groups of 20 specimens each. They were restored with the assigned restorative material, i.e. Composite (Group 1), GIC (Group 2) and Giomer (Group 3). Restorations were finished and polished and then subjected to surface profilometry analysis for determining the surface roughness values followed by simulated aging by thermocycling. These groups were further subdivided into two subgroups consisting of 10 samples each and subjected to manual and ultrasonic prophylactic instrumentation followed by surface profilometric analysis. After polishing using prophylactic paste, once again surface profilometry analysis was done. The data thus obtained were subjected to statistical analysis using SPSS 26.0 (SPSS Inc., Chicago, IL) software. Results and discussion: The highest value for surface roughness was seen with Group 1 (Omnichroma) followed by Group 2 (GC Gold Label hybrid). Group 3 (Beautifil) exhibited lowest value for surface roughness along all the stages. Manual instrumentation groups showed increased surface roughness compared to ultrasonic instrumentation groups. Conclusion: Among the three tested materials, best surface finish at all stages of evaluation was seen with Beautifil, followed by GC Gold label hybrid and the lowest quality was seen with Omnichroma.
Operating list composition and surgical performance
Authors: Pike T W , Mushtaq F , Mann R P , Chambers P , Hall G , Tomlinson J E , Mir R , Wilkie R M , Mon-Williams M , Lodge J P A
Published: March 2018

Background

Recent reviews suggest that the way in which surgeons prepare for a procedure (warm up) can affect performance. Operating lists present a natural experiment to explore this phenomenon. The aim was to use a routinely collected large data set on surgical procedures to understand the relationship between case list order and operative performance.

Method

Theatre lists involving the 35 procedures performed most frequently by senior surgeons across 38 private hospitals in the UK over 26 months were examined. A linear mixed-effects model and matched analysis were used to estimate the impact of list order and the cost of switching between procedures on a list while controlling for key prognosticators. The influence of procedure method (open versus minimally invasive) and complexity was also explored.

Results

The linear mixed-effects model included 255 757 procedures, and the matched analysis 48 632 pairs of procedures. Repeating the same procedure in a list resulted in an overall time saving of 0·98 per cent for each increase in list position. Switching between procedures increased the duration by an average of 6·48 per cent. The overall reduction in operating time from completing the second procedure straight after the first was 6·18 per cent. This pattern of results was consistent across procedure method and complexity.

Conclusion

There is a robust relationship between operating list composition and surgical performance (indexed by duration of operation). An evidence-based approach to structuring a theatre list could reduce the total operating time.
On the phase transition curve in a directed exponential random graph model
Authors: Aristoff David , Zhu Lingjiong
Published: March 2018

We consider a family of directed exponential random graph models parametrized by edges and outward stars. Much of the important statistical content of such models is given by the normalization constant of the models, and, in particular, an appropriately scaled limit of the normalization, which is called the free energy. We derive precise asymptotics for the normalization constant for finite graphs. We use this to derive a formula for the free energy. The limit is analytic everywhere except along a curve corresponding to a first-order phase transition. We examine unusual behavior of the model along the phase transition curve.