bluuebunny/crossref_metadata_2025 huggingface dataset:
Association between Polyphenol Intake and Lipid Profile of Adults and Elders in a Northeastern Brazilian Capital
Authors: de Farias Luciana Melo , Lopes Rodrigues Lays Arnaud Rosal , de Carvalho Lavôr Layanne Cristina , de Lima Alessandro , Sampaio da Paz Suzana Maria Rebêlo , Pereira da Silva Jânyerson Dannys , de Macêdo Gonçalves Frota Karoline , Lucarini Massimo , Durazzo Alessandra , Arcanjo Daniel Dias Rufino , de Carvalho e Martins Maria do Carmo
Published: May 2023

This research was aimed at evaluating the relationship between the estimated polyphenol intake and the atherogenic lipid profile in adult and elder residents in the city of Teresina, located in the Northeastern Region of Brazil. This study was a cross-sectional population-based survey with 501 adults and elders, conducted in Teresina, Brazil. Food intake was obtained by 24-h food recall. The estimated polyphenol intake was calculated by multiplying the food consumption data from the recall by the polyphenol content in the foods described in the Phenol-Explorer database. The mean intake of total polyphenols was 1006.53 mg/day. The phenolic acids was the class with the highest intake, followed by the flavonols. Coffee, beans and apples were the main foods contributing to the total polyphenol intake. In the individuals with elevated serum concentrations of total cholesterol and triglycerides, the intake of total polyphenols was significantly higher. The intake of total polyphenols, phenolic acids and lignans was higher in the subjects with dyslipidemia. This article provides, for the first time, data on the intake of the total polyphenol classes and subclasses in the evaluated population and the relationship with the lipid profile. The individuals with a higher intake of total polyphenols had a worse lipid profile, which may be a consequence of an improved diet in those individuals who present with dyslipidemia.
Sexual Dimorphism in Lipid Metabolism and Gut Microbiota in Mice Fed a High-Fat Diet
Authors: Zhu Qi , Qi Nathan , Shen Ling , Lo Chunmin C. , Xu Meifeng , Duan Qing , Ollberding Nicholas J. , Wu Zhe , Hui David Y. , Tso Patrick , Liu Min
Published: May 2023

The gut microbiome plays an essential role in regulating lipid metabolism. However, little is known about how gut microbiome modulates sex differences in lipid metabolism. The present study aims to determine whether gut microbiota modulates sexual dimorphism of lipid metabolism in mice fed a high-fat diet (HFD). Conventional and germ-free male and female mice were fed an HFD for four weeks, and lipid absorption, plasma lipid profiles, and apolipoprotein levels were then evaluated. The gut microbiota was analyzed by 16S rRNA gene sequencing. After 4-week HFD consumption, the females exhibited less body weight gain and body fat composition and significantly lower triglyceride levels in very-low-density lipoprotein (VLDL) and cholesterol levels in high-density lipoprotein (HDL) compared to male mice. The fecal microbiota analysis revealed that the male mice were associated with reduced gut microbial diversity. The female mice had considerably different microbiota composition compared to males, e.g., enriched growth of beneficial microbes (e.g., Akkermansia) and depleted growth of Adlercreutzia and Enterococcus. Correlation analyses suggested that the different compositions of the gut microbiota were associated with sexual dimorphism in body weight, fat mass, and lipid metabolism in mice fed an HFD. Our findings demonstrated significant sex differences in lipid metabolism and the microbiota composition at baseline (during LFD), along with sex-dependent responses to HFD. A comprehensive understanding of sexual dimorphism in lipid metabolism modulated by microbiota will help to develop more sex-specific effective treatment options for dyslipidemia and metabolic disorders in females.
MultiSero: An Open-Source Multiplex-ELISA Platform for Measuring Antibody Responses to Infection
Authors: Byrum Janie R. , Waltari Eric , Janson Owen , Guo Syuan-Ming , Folkesson Jenny , Chhun Bryant B. , Vinden Joanna , Ivanov Ivan E. , Forst Marcus L. , Li Hongquan , Larson Adam G. , Blackmon Lena , Liu Ziwen , Wu Wesley , Ahyong Vida , Tato Cristina M. , McCutcheon Krista M. , Hoh Rebecca , Kelly J. Daniel , Martin Jeffrey N. , Peluso Michael J. , Henrich Timothy J. , Deeks Steven G. , Prakash Manu , Greenhouse Bryan , Mehta Shalin B. , Pak John E.
Published: May 2023

A multiplexed enzyme-linked immunosorbent assay (ELISA) that simultaneously measures antibody binding to multiple antigens can extend the impact of serosurveillance studies, particularly if the assay approaches the simplicity, robustness, and accuracy of a conventional single-antigen ELISA. Here, we report on the development of multiSero, an open-source multiplex ELISA platform for measuring antibody responses to viral infection. Our assay consists of three parts: (1) an ELISA against an array of proteins in a 96-well format; (2) automated imaging of each well of the ELISA array using an open-source plate reader; and (3) automated measurement of optical densities for each protein within the array using an open-source analysis pipeline. We validated the platform by comparing antibody binding to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) antigens in 217 human sera samples, showing high sensitivity (0.978), specificity (0.977), positive predictive value (0.978), and negative predictive value (0.977) for classifying seropositivity, a high correlation of multiSero determined antibody titers with commercially available SARS-CoV-2 antibody tests, and antigen-specific changes in antibody titer dynamics upon vaccination. The open-source format and accessibility of our multiSero platform can contribute to the adoption of multiplexed ELISA arrays for serosurveillance studies, for SARS-CoV-2 and other pathogens of significance.
Penetration of Triphenylphosphonium Derivatives through the Cell Envelope of Bacteria of Mycobacteriales Order
Authors: Nazarov Pavel A. , Majorov Konstantin B. , Apt Alexander S. , Skulachev Maxim V.
Published: May 2023

The penetration of substances through the bacterial cell envelope is a complex and underinvestigated process. Mitochondria-targeted antioxidant and antibiotic SkQ1 (10-(plastoquinonyl)decyltriphenylphosphonium) is an excellent model for studying the penetration of substances through the bacterial cell envelope. SkQ1 resistance in Gram-negative bacteria has been found to be dependent on the presence of the AcrAB-TolC pump, while Gram-positive bacteria do not have this pump but, instead, have a mycolic acid-containing cell wall that is a tough barrier against many antibiotics. Here, we report the bactericidal action of SkQ1 and dodecyl triphenylphospho-nium (C12TPP) against Rhodococcus fascians and Mycobacterium tuberculosis, pathogens of plants and humans. The mechanism of the bactericidal action is based on the penetration of SkQ1 and C12TPP through the cell envelope and the disruption of the bioenergetics of bacteria. One, but probably not the only such mechanism is a decrease in membrane potential, which is important for the implementation of many cellular processes. Thus, neither the presence of MDR pumps, nor the presence of porins, prevents the penetration of SkQ1 and C12TPP through the complex cell envelope of R. fascians and M. tuberculosis.
Linewidth Narrowing of a Dual Wavelength-Selectable, Ring Cavity Erbium-Doped Fiber Laser Using a Saturable Absorber
Authors: Okafor Ebuka E. , Igboamalu Frank N. , Ouahada Khmaies , Hamam Habib
Published: May 2023

The narrow linewidth fiber laser is useful in applications such as fiber sensing, optical communications, and spectroscopy. This paper presents an investigation of the model and an experiment of a stable, wavelength-selective, narrow linewidth, ring cavity erbium-doped fiber laser incorporating two fiber Bragg gratings (FBG) at 1530.18 nm and 1550.08 nm, respectively. An F-P tunable filter was used to select a specific wavelength after optimizing the spectral output from the two FBGs to measure their respective linewidths. The erbium-doped ring fiber laser was optimized by adjusting the optical cavity loss using a variable optical coupler at a coupling ratio of 95%. The variable coupler was set to an optimal coupling ratio of 95%, where the spectral output powers of 3.4 mW at 1530.18 nm and 3.1 mW at 1550.08 nm were achieved as the optimal fiber laser output powers. The balanced output power had an optical signal-to-noise ratio of (OSNR) of 61 dB for each wavelength. The linewidth was measured for both wavelengths without saturable absorbers, and 27.7 kHz and 28.3 kHz for 1530.18 nm and 1550.08 nm were obtained. Using the saturable absorber, the linewidths were narrowed to 25.3 KHz and 21.1 kHz for 1530.18 nm and 1550.08 nm, respectively.
Metal–Polymer Nanocomposites: A Promising Approach to Antibacterial Materials
Authors: Ghazzy Asma , Naik Rajashri R. , Shakya Ashok K.
Published: May 2023

There has been a new approach in the development of antibacterials in order to enhance the antibacterial potential. The nanoparticles are tagged on to the surface of other metals or metal oxides and polymers to achieve nanocomposites. These have shown significant antibacterial properties when compared to nanoparticles. In this article we explore the antibacterial potentials of metal-based and metal–polymer-based nanocomposites, various techniques which are involved in the synthesis of the metal–polymer, nanocomposites, mechanisms of action, and their advantages, disadvantages, and applications.
Description of Poly(aryl-ether-ketone) Materials (PAEKs), Polyetheretherketone (PEEK) and Polyetherketoneketone (PEKK) for Application as a Dental Material: A Materials Science Review
Authors: Zol Syazwani Mohamad , Alauddin Muhammad Syafiq , Said Zulfahmi , Mohd Ghazali Mohd Ifwat , Hao-Ern Lee , Mohd Farid Durratul Aqwa , Zahari Nur A’fifah Husna , Al-Khadim Aws Hashim Ali , Abdul Aziz Azrul Hafiz
Published: May 2023

Poly(aryl-ether-ketone) materials (PAEKs), a class of high-performance polymers comprised of polyetheretherketone (PEEK) and polyetherketoneketone (PEKK), have attracted interest in standard dental procedures due to their inherent characteristics in terms of mechanical and biological properties. Polyetheretherketone (PEEK) is a restorative dental material widely used for prosthetic frameworks due to its superior physical, mechanical, aesthetic, and handling features. Meanwhile, polyetherketoneketone (PEKK) is a semi-crystalline thermoplastic embraced in the additive manufacturing market. In the present review study, a new way to fabricate high-performance polymers, particularly PEEK and PEKK, is demonstrated using additive manufacturing digital dental technology, or 3-dimensional (3D) printing. The focus in this literature review will encompass an investigation of the chemical, mechanical, and biological properties of HPPs, particularly PEEK and PEKK, along with their application particularly in dentistry. High-performance polymers have gained popularity in denture prosthesis in advance dentistry due to their flexibility in terms of manufacturing and the growing interest in utilizing additive manufacturing in denture fabrication. Further, this review also explores the literature regarding the properties of high-performance polymers (HPP) compared to previous reported polymers in terms of the dental material along with the current advancement of the digital designing and manufacturing.
An Open-Source ABAQUS Plug-In for Delamination Analysis of 3D Printed Composites
Authors: Polyzos Efstratios , Van Hemelrijck Danny , Pyl Lincy
Published: May 2023

This article presents the development and implementation of the Delamination Plug-in, an open-source tool for modeling delamination tests in the ABAQUS software. Specifically designed for stochastic modeling of 3D printed composites, the plug-in combines the benefits of the graphical user interface (GUI) and the programming of commercial finite element (FE) software. The Delamination Plug-in offers an effortless alternative to the time-consuming analytical modeling and GUI work involved in delamination tests and includes algorithms for several tests, such as the double cantilever beam, end-loaded split, end-notched flexure, and modified end-loaded split tests, solved using the virtual crack closure technique and the cohesive zone method. It enables the user to develop simulations for both simple symmetric laminates and generally layered laminates with additional thermal stresses. The applicability of the tool is demonstrated through its use in two distinct delamination problems, one for conventional and one for 3D printed composite laminates, and its results are compared to analytical models and experimental data from the open literature. The results demonstrate that the Delamination Plug-in is efficient and applicable for such materials. This establishes the tool as an important means of automating delamination analysis and for the development and testing of 3D printed composites, making it a valuable tool for both researchers and industry professionals.
Predicting Erectile Dysfunction after Highly Conformal, Hypofractionated Radiotherapy to the Prostate
Authors: Martell Kevin , Bayley Conrad , Quirk Sarah , Braun Jeremy , Sun Lingyue , Smith Wendy , Quon Harvey , Thind Kundan
Published: May 2023

Background: Erectile dysfunction (ED) is common after prostate cancer treatment. It has been studied for conventional radiotherapy, but associations in the hypofractionated radiotherapy context are less clear. This study aimed to determine which factors are predicted for worsening ED after highly conformal, modestly hypofractionated radiotherapy to the prostate. Methods: Two hundred and twelve patients treated with 6000 cGy in twenty fractions across four centers were included in this study. Demographic, clinical, and dosimetry factors were then evaluated for post-treatment declines in erectile function using logistic regression and an explainable machine learning-based neural network. Results: 212 patients with a median follow-up of 3.6 years were evaluated. A total of 104 (49%) patients received androgen deprivation therapy. Prior to treatment, 52 (25%) patients were on ED medication. Mean doses to the penile bulb, penile crus, and penile shaft were 2490 (IQR: 1529–3656) cGy, 2095 (1306–3036) cGy, and 444 (313–650) cGy, respectively. Fifty-nine (28%) patients had a worsening of ED after treatment. On multivariable analysis, only the mean dose to the penile shaft [OR >345 vs. ≤345: 4.47 (1.43–13.99); p = 0.010] and pretreatment use of ED medication [OR yes vs. no: 12.5 (5.7–27.5; p < 0.001)] predicted for worsening ED. The neural network confirmed that the penile shaft mean dose and pre-treatment ED medication use are the most important factors in predicting ED. Conclusions: Pre-treatment ED and penile shaft dosimetry are important predictors for ED after hypofractionated radiotherapy for prostate cancer.
Quantification of Microtopography in Natural Ecosystems Using Close-Range Remote Sensing
Authors: Shukla Tarini , Tang Wenwu , Trettin Carl C. , Chen Gang , Chen Shenen , Allan Craig
Published: May 2023

Microtopography plays an important role in various ecological, hydrologic, and biogeochemical processes. However, quantifying the characteristics of microtopography represents a data-intensive challenge. Over the last decade, high-resolution or close-range remote sensing data and techniques have emerged as powerful tools to quantify microtopography. Traditional field surveys were mostly limited to transects or small plots, using limited sets of observations but with the decrease in the cost of close-range remote sensing technologies and the increase in computing performance, the microtopography even in forested environments can be assessed. The main objective of this article is to provide a systematic framework for microtopographic studies using close-range remote sensing technologies. This is achieved by reviewing the application of close-range remote sensing to capture microtopography and develop microtopographic models in natural ecosystems. Specifically, to achieve the main objectives, we focus on addressing the following questions: (1) What terrain attributes represent microtopography in natural ecosystems? (2) What spatial resolution of terrain attributes is needed to represent the microtopography? (3) What methodologies have been adopted to collect data at selected resolutions? (4) How to assess microtopography? Current research, challenges, and applicability of close-range remote sensing techniques in different terrains are analyzed with an eye to enhancing the use of these new technologies. We highlight the importance of using a high-resolution DEM (less than 1 m2 spatial resolution) to delineate microtopography. Such a high-resolution DEM can be generated using close-range remote sensing techniques. We also illustrate the need to move beyond elevation and include terrain attributes, such as slope, aspect, terrain wetness index, ruggedness, flow accumulation, and flow path, and assess their role in influencing biogeochemical processes such as greenhouse gas emissions, species distribution, and biodiversity. To assess microtopography in terms of physical characteristics, several methods can be adopted, such as threshold-based classification, mechanistically-based delineation, and machine learning-based delineation of microtopography. The microtopographic features can be analyzed based on physical characteristics such as area, volume, depth, and perimeter, or by using landscape metrics to compare the classified microtopographic features. Remote sensing techniques, when used in conjunction with field experiments/data, provide new avenues for researchers in understanding ecological functions such as biodiversity and species distribution, hydrological processes, greenhouse gas emissions, and the environmental factors that influence those parameters. To our knowledge, this article provides a comprehensive and detailed review of microtopography data acquisition and quantification for natural ecosystem studies.
Resisting Fear: The Role of Problem-Solving Appraisals in Post-Traumatic Stress Disorder and Depression
Authors: Pretorius Tyrone B. , Padmanabhanunni Anita
Published: May 2023

The COVID-19 pandemic represented a global public health emergency and was associated with adverse mental health outcomes. Individual differences in response to traumatic stressors can be attributed to subjective cognitive appraisals. The current study investigated the role of problem-solving appraisals in the association between COVID-19-related fear and mental health outcomes. Participants were university students (N = 322). They completed a web-based survey comprising the Center for Epidemiological Studies depression scale, the fear of COVID-19 scale, the problem-solving inventory, the post-traumatic stress disorder (PTSD) checklist, and the satisfaction with life scale. Correlational analysis revealed that a heightened fear of COVID-19 was related to greater PTSD and depressive symptoms and a lower life satisfaction. Self-appraised ineffective problem-solving was associated with higher levels of PTSD and depression and a lower life satisfaction. Problem-solving appraisal moderated the relationship between fear of COVID-19, life satisfaction, PTSD, and depression, respectively. The findings suggest that problem-solving appraisals are a protective resource and have the potential to promote positive psychological functioning among young adults.
Performing Fat Liberation: Pretty Porky and Pissed Off’s Affective Politics and Archive
Authors: Taylor Allison , Mitchell Allyson , Rice Carla
Published: May 2023

This article uses collaborative auto/ethnography to explore the circulation and potentiality of affect in the live performances and archive of Pretty Porky and Pissed Off (PPPOd), a Toronto-based queer fat activist performance art collective active during the late 1990s and mid-2000s. Drawing on video and audio recordings of five PPPOd performances alongside other performance ephemera and a series of conversations relating to these archival objects among the article’s three authors, we identify and theorize our affective responses to and situated recollections of these performances, both in their current form as archival objects and as historical live events. We argue that PPPOd’s archival objects/live performances disrupt the constellation of affects that constitute fat hate (e.g., fear, loathing, shame) and set in motion more affirmative affects (e.g., playfulness, pride, desire, love) that contribute to micro-worldings and prefigurative fat politics, as ephemeral as these might be. In capturing these fleeting moments of radical possibility, PPPOd’s activism and archive offer opportunities for touching and feeling a future where fat lives are more livable.
Teaching Sustainability Using 3D Printing in Engineering Education: An Observational Study
Authors: To Thanh Tuan , Al Mahmud Abdullah , Ranscombe Charlie
Published: May 2023

One of the many features of three-dimensional printing (3DP) that contribute to its status as a cutting-edge technology is its positive impact on sustainability. Students in higher education can also use 3DP technologies to understand environmental, social, and economic issues. However, there is a lack of knowledge on how sustainability is integrated through 3DP in higher education, especially in developing countries. Thus, this research explored the teaching of sustainability through 3DP in five public engineering universities in Vietnam using field observations (75 students and five educators), followed by semi-structured interviews with ten students and five educators. The findings revealed that sustainability through 3DP was not taught as a separate unit in the participating institutions as they were not equipped with the necessary tools and software to educate students about sustainability through 3DP, the time spent teaching students about 3DP was limited, and most of the educators were not trained in implementing sustainability through 3DP in higher education. Despite these barriers, students were instructed on how to use 3DP materials economically and were taught which materials were beneficial for the environment. In cases of limited resources and funding, assisting students in assembling low-cost do-it-yourself 3D printers by utilizing open-source materials will maximize their learning outcomes. These findings may help higher education institutions teach sustainability through 3DP and motivate students to explore multidisciplinary knowledge in developing countries. This study also guides both higher education sectors and policymakers on taking the steps necessary for utilizing the benefits of 3DP in engineering education.
Could Cryptocurrency Policy Uncertainty Facilitate U.S. Carbon Neutrality?
Authors: Su Chi-Wei , Song Yuru , Chang Hsu-Ling , Zhang Weike , Qin Meng
Published: May 2023

Investigating the essential impact of the cryptocurrency market on carbon emissions is significant for the U.S. to realize carbon neutrality. This exploration employs low-frequency vector auto-regression (LF-VAR) and mixed-frequency VAR (MF-VAR) models to capture the complicated interrelationship between cryptocurrency policy uncertainty (CPU) and carbon emission (CE) and to answer the question of whether cryptocurrency policy uncertainty could facilitate U.S. carbon neutrality. By comparison, the MF-VAR model possesses a higher explanatory power than the LF-VAR model; the former’s impulse response indicates a negative CPU effect on CE, suggesting that cryptocurrency policy uncertainty is a promoter for the U.S. to realize the goal of carbon neutrality. In turn, CE positively impacts CPU, revealing that mass carbon emissions would raise public and national concerns about the environmental damages caused by cryptocurrency transactions and mining. Furthermore, CPU also has a mediation effect on CE; that is, CPU could affect CE through the oil price (OP). In the context of a more uncertain cryptocurrency market, valuable insights for the U.S. could be offered to realize carbon neutrality by reducing the traditional energy consumption and carbon emissions of cryptocurrency trading and mining.
Assessing the Effectiveness of Ecological Mitigation Practices in Public Construction with a Quick and Operational Assessment Framework
Authors: Tsai Yie-Wen , Lin Jen-Yang , Chen Chi-Feng
Published: May 2023

Infrastructures (public constructions) are necessary for people’s lives, but large infrastructures can be harmful to local ecosystems and wildlife. The ecological mitigation practices of more than 5000 public construction projects in Taiwan were reviewed. Among these cases, the reduction practices were 38%–58%, and the avoiding, minimizing, and compensation measures were nearly 20%. However, the number of statistical measures did not reflect the actual performance. This study developed a quick and operational assessment framework to assess ecological mitigation measures. The four indicators were ecological concern areas, number of ecological conservation measures, number of ecological conservation objects, and habitat quality. The assessment indicators were applied to 54 construction cases, and their performance was classified into excellent, good, fair, and qualified. The developed assessment indicators were proven capable of serving as a preliminary tool to determine the performance of ecological mitigation practices, and the criteria standard can be adjusted as cases are updated.
The Relationship between Firm Attributes and Attitudes towards Diversity
Authors: Fodor Máté Miklós , Komorowski Marlen , Turegeldinova Aliya
Published: May 2023

The attitudes of creative firms towards issues of equality, diversity and inclusiveness (“EDI”) can significantly affect their willingness to sponsor and implement effective measures in the domain. It is, therefore, essential to examine the readily measurable firm attributes that influence these attitudes. We have collected a wide range of data on almost 330 creative businesses. Our empirical investigation establishes a robust and unequivocal pattern. It indicates that more established companies tend not to view the underrepresentation or the discrimination of people with various protected characteristics as problematic. Young, innovative and efficient firms on the other hand are systematically more likely to consider these same issues as prevalent. These findings are in line with the conclusions from the previous literature which relied predominantly on anecdotal evidence. The patterns that we document suggest that EDI policies and recommendations must be tailored to the precise characteristics of the firm implementing them.
A Platform of Critical Barriers to Socially Sustainable Residential Buildings: Experts’ Perspective
Authors: Golić Kosa , Kosorić Vesna , Kosić Tatjana , Vučković Slavica Stamatović , Kujundžić Kosara
Published: May 2023

The concept of sustainable cities and communities is endorsed as one of the seventeen goals of sustainable development. Since buildings represent an essential element of the city, they play a primary role in achieving the social, economic, and environmental sustainability of cities. Previous studies have pointed to the lack of emphasis on the social aspect of buildings. Aiming to fill the gap, this research is focused on identifying barriers that hinder the adoption of social sustainability (SS) measures and practices in residential buildings, as a first step in overcoming these barriers and enabling faster achievement of SS goals. The initial platform of barriers was derived from a comprehensive review of the published literature, international reports, and green building rating systems. For the selection of critical barriers, the Delphi method was used with the participation of 60 international experts. Of 58 barriers initially identified from the literature and experts’ suggestions, 29 were selected as important and classified into five groups. Further, in each of these groups three barriers were singled out, the overcoming of which would facilitate and speed up buildings’ SS to the greatest extent. These results provide insight into barriers to SS for policy makers, developers, and planners, invite further studies on this topic, and provide a starting point for other researchers to identify the most relevant barriers in different contexts, i.e., countries and regions with their specific characteristics. This will further create the conditions for the elimination of barriers to SS by focusing on the most critical issues.
Univalence and Starlikeness of Certain Classes of Analytic Functions
Authors: Alarifi Najla M. , Obradović M.
Published: May 2023

For the analytic functions ϕ(ζ)=ζ+∑k=n∞ϕkζk in the unit disk O, we calculate the values of n and α, where the condition ℜ1+ζϕ″(ζ)/ϕ′(ζ)>−α or ℜ1+ζϕ″(ζ)/ϕ′(ζ)<1+α/2 yields univalence and starlikeness. Conditions imply ϕ in the class where all normalized analytic functions U, with ζ/ϕ(ζ)2ϕ′(ζ)−1<1 are obtained. Recent findings are gained, and unique cases are demonstrated. The generalization of the Jack lemma serves the proof of the main result and that our methodology is based on the idea of subordination.
Virus-like Particle Vaccines and Platforms for Vaccine Development
Authors: Kheirvari Milad , Liu Hong , Tumban Ebenezer
Published: May 2023

Virus-like particles (VLPs) have gained a lot of interest within the past two decades. The use of VLP-based vaccines to protect against three infectious agents—hepatitis B virus, human papillomavirus, and hepatitis E virus—has been approved; they are very efficacious and offer long-lasting immune responses. Besides these, VLPs from other viral infectious agents (that infect humans, animals, plants, and bacteria) are under development. These VLPs, especially those from human and animal viruses, serve as stand-alone vaccines to protect against viruses from which the VLPs were derived. Additionally, VLPs, including those derived from plant and bacterial viruses, serve as platforms upon which to display foreign peptide antigens from other infectious agents or metabolic diseases such as cancer, i.e., they can be used to develop chimeric VLPs. The goal of chimeric VLPs is to enhance the immunogenicity of foreign peptides displayed on VLPs and not necessarily the platforms. This review provides a summary of VLP vaccines for human and veterinary use that have been approved and those that are under development. Furthermore, this review summarizes chimeric VLP vaccines that have been developed and tested in pre-clinical studies. Finally, the review concludes with a snapshot of the advantages of VLP-based vaccines such as hybrid/mosaic VLPs over conventional vaccine approaches such as live-attenuated and inactivated vaccines.
The role of the otorhinolaryngologist nurse in treatment acute diseases of the middle ear
Authors:   SBHI SR Samara City Clinical Polyclinic No. 15 of the Industrial District, Samara, Russia, Kiseleva Yu. A.
Published: May 2023

Inflammatory diseases of the middle ear often consistently affect the mucous membrane of all its parts: the auditory tube, the tympanic membrane, and the mastoid cells. Acute otitis media is the most common complication of acute respiratory infections. According to statistics, the frequency of acute otitis media ranges from 25 to 30 % of the total number of ear diseases, which indicates its fairly wide prevalence. Inflammation of the middle ear often leads to a disorder in the auditory function, and in order to prevent hearing loss, it is necessary to start following the doctor's prescriptions in a timely manner.
Development of bilateral economic relations between Russia and Turkey
Authors:   Bashkir State University, Institute of Law, Ufa, Nikitina A. A. , Shafieva K. R. ,   Bashkir State University, Institute of Law, Ufa
Published: May 2023

Russia and Turkey are the largest powers influencing the international economy, diplomacy and the geopolitical climate on the European continent. In the conditions of anti-Russian sanctions, a huge role is assigned to strengthening relations between friendly states, searching for mutually beneficial directions and projects that will strengthen the economic well-being of partner states. In this regard, the establishment of diplomatic and economic relations between Russia and Turkey will allow Russia to maintain its position on the European continent. Turkey occupies an important geopolitical position at the same time being a European, Asian, Balkan, Caucasian, Middle Eastern, Mediterranean and Black Sea region. It unites the entire Eurasian space, thereby strengthening its role in the political space. Viewed from a regional perspective, the fact remains that trade between the two States is also important for world trade. Historically, it can be traced that from time to time problems arise between states, which negatively affects economic cooperation between them, since politics directly affects the economy and trade relations of countries. But, when building diplomatic ties, first of all, historical experience in relations between states should be taken into account and all the positive and negative sides should be taken into account. Taking into account all the regulatory legal acts considered, the authors of the article put up for discussion the issue of stabilization of bilateral relations between Russia and Turkey, and propose the most promising directions for strengthening relations between the states. The study is based on the analysis of official statistical indicators of Turkstat and Goskomstat, describing the state of development of foreign economic cooperation between Russia and Turkey.
Concentration in the housing construction market in Russia on the example of Moscow and the prospects for further industry consolidation
Authors:   Plekhanov Russian University of Economics (PRUE named after G.V. Plekhanov), Moscow, Kornienko D. O.
Published: May 2023

The Russian residential real estate market has been largely restructured in recent years. In 2019, the transition to the use of escrow accounts began, in 2020 the market faced the coronavirus pandemic, in 2022 the market began to go through another crisis, demonstrating a significant decrease in sales at the end of the year. At the same time, both state support programs and joint actions of banks and developers were the mitigant of the ongoing shocks in the market. For example, the launch of mortgage subsidy programs by industry leaders quickly spread throughout the market — the actions of PIK, Samolet, Level Group to expand these programs to "mortgages at 0.1 %" forced other players to reconsider their pricing policy. However, not all developers are able to quickly adapt to changing market conditions. However, since January 2023, the practice of low mortgage rates has been largely limited by the regulator due to increased systemic risks. In this regard, the residential construction segment is once again facing a major challenge for the industry. Many developers leave the market as single projects are completed because: not everyone can fi nd the required capital; not everyone gets credit lines from banks; not everyone is able to withstand the turbulence in the economy. In this regard, there is a hypothesis that the housing construction market is becoming less and less competitive, and in the next 1–2 years the concentration in the industry will only increase.
La productividad en la empresa de la industria de la transformación
Authors: Ulloa-Pimienta Ana Ruth , Sánchez-Trinidad Adriana del Carmen , Balcazar-Sosa Maria Teresa de Jesús
Published: May 2023

La productividad empresarial es uno de los factores claves para el éxito de un negocio. Cualquier empresa no importa su giro, su tamaño o su cometido, tiene como finalidad principal producir lo máximo y mejor posible. Esforzarse por lograr la máxima eficiencia y eficacia en cada uno de los procesos de la organización, debe ser una prioridad.

La productividad es un indicador crucial, que debe medirse en forma objetiva y rigurosa y todas las empresas deberían de ser capaces de saber exactamente cómo es su productividad, en qué se basa esta y en qué fallan.

El objetivo de la presente investigación expone la medición que se obtuvo de la productividad de una empresa mediana en el sector de la transformación, que desde hace un año presenta un grado considerable deficiente en la productividad lo que conlleva a otras dificultades con la producción, por ello resulto relévate utilizar los criterios básicos que las organizaciones necesitan para poder lograr la calidad y por ende la productividad.

Atraves de los resultados obtenidos se realizo un análisis, por lo cual se pudo establecer un modelo metodológico de mejoramiento para la organización, con un enfoque sistémico, esto quiere decir que estarán involucradas todas las partes que conforman a la empresa, en la implantación de dicha propuesta, logrando con ello que su productividad sea la que verdaderamente debe alcanzar, con ello se ubicara en el nivel de competitividad que debe de tener según los recursos involucrados. Para lograr una buena productividad empresarial es imprescindible una buena gestión de los recurso de la misma, con ello tambien se engloba un conjunto de técnicas que se aplican al conjunto de una empresa, hay que tomar en cuenta que el objetivo de la gestión de los recursos es mejorar la productividad, sostenibilidad y competititividad.

Un logro importante en la investigación fue integrar significativamente al personal de la organización en la cultura de la medición con su participación, y por lo cual se considera que este es un inicio relevante para la empresa estudiada.
Efecto del compostaje de desechos orgánicos municipales en la enmendación del drenaje ácido de mina
Authors: Sucari León Anibal , Pastor Contreras Wilber , Sucari León Reynaldo , Aroquipa Duran Yolanda , Chambi Condori Nancy , Ticona Arapa Haydee Clady
Published: May 2023

La responsabilidad ambiental de las empresas mineras es una preocupación nacional ya que contaminan las aguas subterráneas y superficiales debido a la generación de drenaje ácido de mina que contiene metales pesados afectando la salud de los seres vivos. El objetivo de la investigación fue conocer el impacto del compostaje de desechos orgánicos municipales en la enmendación de drenaje ácido de mina. Se desarrolló bajo la guía metodológica del enfoque cuantitativos, ya que se manipularon las variables independientes, utilizando un diseño experimental realizando mediciones en los grupos experimental y control a las 0, 24, 48 y 72 horas. Los resultados mostraron que el compostaje tuvo un efecto positivo en la enmendación de drenaje ácido de mina, logrando una disminución de la acides (pH = 2,52 a 6,2) por otra parte, se eliminó en su totalidad la concentración de los metales pesados como el arsénico, mercurio y plomo, sin embargo en el caso del cadmio la concentración bajó de 3,0 a 0,8. Concluyendo que el compostaje de residuos orgánicos domiciliarios tiene un efecto positivo en la enmendación de drenajes ácidos de mina, ya que incrementa el valor del pH y reduce la concentración de metales pesados
The Indonesian Government Imagery in the Instagram Comic strip with Covid-19 Themed
Authors:   Magister Design Department, Postgraduate Faculty, Universitas Komputer Indonesia, Indonesia, Pratama D M , Kasmana K ,   Magister Design Department, Postgraduate Faculty, Universitas Komputer Indonesia, Indonesia
Published: May 2023

At the beginning of 2020, there has been the spread of the deadly Covid-19 virus to various countries resulted in a pandemic. Indonesia is one of the countries affected, so the government provides a policy that is expected to reduce the number of Covid-19 cases. The policy issued has drawn criticism from various parties, one of which is the cartoon mice comic, this comic is one of the comics that often comments on social life and the Indonesian government with its comic strips posted on Instagram. This study aims to find the image and role of the government depicted in mice cartoon comics in overcoming Covid-19 in Indonesia, therefore there is a need for analysis and research with descriptive methods and critical discourse analysis approaches to see how the image of the Indonesian government in comic mice cartoons. The results of the analysis of the two comics concluded that the image of the government displayed in the comic strip did not only come from the author's idea but also based on the news that emerged from the government's response to the spread of the Covid-19 virus in Indonesia, with an image style that was distinctive from mice cartoon comics. With this research, the researcher hopes that it can become a recommendation in making comic narratives, especially those discussing social life and government, and can be a reference for research that has the same object.
Indonesian Response to Covid-19 Poster as Indicator of Collective Visual Literacy (Bandung Case Study)
Authors:   Visual Communication Design Study Program, Universitas Komputer Indonesia, Indonesia, Maulina Rini
Published: May 2023

The covid-19 pandemic ongoing to this day in Indonesia, health protocol regulations established by the government to prevent transmission in the community. Various information of health protocols made by print and digital media is widely spread. However, it seems that does not have much impact, this can be seen from the increasing covid-19 transmission rate in Indonesia. It is necessary to see how the preferences of Indonesians, especially the people of Bandung who are teenagers in reading visual posters covid-19, the level of visual reading ability as a message is smeared with the level of visual literacy. The research was conducted through three poster themed covid-19 resulting from the application of visual argument methods wich is listed on questionnaire questions to measure the visual literacy capabilities of respondents. The analysis showed respondents aged between 18-24 years were more likely to choose posters with large portions of text, other results showed if the text was removed from the visual (visual argument method without text), the respondent could not capture the message on the poster. This has an impact on understanding the captured messages. This condition shows low levels of visual literacy among teenagers in Bandung.
The Popo and Komikazer Illustration on Tokai Gas Lighter that can Influence Buyer Interest
Authors:   Department of Visual Communication Design, Faculty of Design, Universitas Komputer Indonesia, Indonesia, Hardoyo A B
Published: May 2023

The purpose of the research is to find out the cartoon illustration of The Popo who collaboration with Komikazer which is placed on a Tokai gas lighter brand can increase purchase interest. The method used in this research is quantitative by describe the illustration who applied to gas lighter and conducting questionnaries about that illustration on a match to respondents to produce data to know the conclusion. The result obtained from the research is knowledge in form of placing illustration The Popo and Komikazer on a gas lighter can be increase interest in deciding to buy a gas lighter match and the message in an illustration can be important in increasing the interest of potential customers.
Multi-Participant Identity Figures in Indonesian Animated Films
Authors: Ekawardhani Y A , Santosa I , Ahmad H A , Irfansyah I
Published: May 2023

The purpose of this research is to find Indonesian multiculturalism in animated film characters. Fictional characters are human copies of the real world. Characters are positioned to live life in the world of animation. The relationship between characters is manifested when there is an attachment of cultural identity. The characterizations in Indonesian animated films show the complexity of creation. This concept refers to the view that the more complex the characters are, the more memorable the audience will be. This research uses ethnographic method, given that the characters have a cultural identity. Characters are placed as objects that have mental and motivational qualities. In addition, there is the use of cultural symbols, which indicates multiculturalism. The identity of the characters refers to the unified heuristic of Stets and Burke's theory of identity. Meanwhile, the apparent multiculturalism refers to Ricardo L. Garcia's theory of multiculturalism. The condition of Indonesia, which has been based on pluralism from the start, really understands the existence of differences. So that consciously accept the occurrence of cultural syncretism. The results of this study indicate that Indonesian animated film characters tend to show the application of multiculturalism. And, multiculturalism has become an identity. Multiculturalism is proof of acceptance of this condition, and is manifested through animated film characters.
Nível de controle da asma em pacientes atendidos no serviço de atenção primária em um município do sudoeste da Bahia
Authors: David Victória Íris Lemos , Biondi Loren Freitas , Teixeira Maria Luisa Santos , Bispo Larissa Farias dos Santos , Ladeia Roberta Alves , Martins Ana Letícia , Luna Camila Fernandes Costa , Da Cruz André Fabricio Pereira
Published: May 2023

A asma é uma manifestação crônica que afeta crianças e adultos e representa um problema de saúde pública mundial. Trata-se de uma doença inflamatória das vias aéreas, definida por aumentar a responsividade a estímulos sensíveis. É uma doença mais prevalente em crianças do sexo masculino e mulheres adultas. No Brasil, existem aproximadamente 20 milhões de asmáticos. Alguns fatores de risco são desencadeadores de crises asmáticas, incluindo tabagismo, comorbidades, mudanças climáticas e poluição. O presente trabalho teve como objetivo avaliar o nível de controle da asma em pacientes atendidos na atenção primária em um município do sudoeste da Bahia. Desta forma essa pesquisa trata-se de um estudo de caráter descritivo, com análise quantitativa, exploratória de campo, a fim de identificar o grau de adesão do tratamento farmacológico e não farmacológico dos pacientes asmáticos. Os resultados demonstraram que há boa adesão medicamentosa e não medicamentosa por parte dos asmáticos e que a rinite foi um fator relevante nos entrevistados, reafirmando a coexistência de ambas as patologias em sua maioria. O gênero mais afetado foi o sexo feminino. Os dados indicam a adequação do tratamento farmacológico e não farmacológico em pacientes atendidos na atenção primária de saúde do município.
O conflito entre o interesse economico e a reforma institucional sutentável
Authors: Da Silva César Augusto Antonio
Published: May 2023

A Política do Consumo desenfreado fomentado pelo interesse econômico das grandes Corporações Capitalistas e compradas pelas populações têm gerando um alargamento na desigualdade social e nos problemas ambientais, porque para suprir a necessidade de consumo das pessoas os produtores têm deixado de lado questões ambientais e sociais em busca do aumento de produção. Diante dessa questão, como os Governos tentam reformular o conceito de Estado Social de Direito e nele implantar a questão do Risco, tanto social quanto ambiental sem que essas reformar institucionais deixem de lado ou problematizem o crescimento econômico e a aumento de poder de compra e consumo das populações.