bluuebunny/crossref_metadata_2025 huggingface dataset:
In-situ biosynthetic BC/zeolite hybrid hemostat for quick clot
Authors: Wang Yang , Li Zhuquan , Liao Shiqin , Kong Yan , Wang Qingqing , Wei Qufu
Published: July 2022

Zeolite-based hemostatic agents are considered as an outstanding material to achieve rapid and definitive hemostasis in pre-hospital management. However, developing a safer zeolitic hemostat that avoids the potential thrombotic risk caused by tiny zeolites residue in bleeding wounds remains a critical challenge. In this research, mesoporous zeolite particles are firmly embedded into bacterial cellulose nanofibrous aerogels (termed BC/zeolite NFAs) via an economical and eco-friendly in-situ biosynthetic process. After calcium ion exchange process, the BC/zeolite-Ca NFAs display efficient hemostatic properties due to their inherent high absorbency and procoagulant activity. In vitro hemostatic experiments indicate that the BC/zeolite-Ca NFAs can rapidly initiate and propagate the coagulation cascade to promote blood clot formation. Significantly, the blood clotting time is decreased from 7.5 ± 0.3 min to 2.2 ± 0.3 min when employing the BC/zeolite-Ca NFAs. This work demonstrates that the in-situ biosynthesized BC- and zeolite-based hemostats have potential applications in pre-hospital hemostasis management.
Study on Dynamic Mechanical Properties of Bedding Shale Under Impact Load
Authors: Cheng Hongmei , Feng Yunhu , Xiao Guangming , Zhang Xiangqi , Chen Heng
Published: July 2022

In the actual mining process of shale gas, the loads and disturbances imposed on shale by man-made activities are a dynamic process. Therefore, the study of the dynamic constitutive theory of bedding shale under impact load has important theoretical value for the study of fracturing reformation of shale reservoirs and shale gas production. The objective is to explore the dynamic mechanical properties and fracture characteristics of shale with different bedding dip angles under medium and high strain rate loading. The split Hopkinson bar (SHPB) is used to conduct rock dynamic tests on shales with bedding dip angle of 0°, 30°, 60°, 90°. Based on fractal theory, we calculate the relationship between fractal dimension and broken fragments. The results show that the compressive strength and elastic modulus of shale change slowly when loaded at low strain rate, but when loaded at high strain rate, its compressive strength and elastic modulus increase significantly. The failure mode of shale is also transitioned from splitting failure at low strain rate to shear failure at high strain rate. Under high strain rate loading, the impact of loading rate on the dynamic mechanical properties of shale is greater than that of bedding dip. The mechanical behavior of shale under dynamic load is of great significance to the safe exploitation of shale gas and other resources.
WSMP: A Warp Scheduling Strategy Based on MFQ and PPF
Authors: Fang Juan , Zhao Li’ang , Cai Min , Yang Huijing
Published: July 2022

Normally, threads in a warp do not severely interfere with each other. However, the scheduler must wait until all the threads within complete before scheduling the next warp, resulting in memory divergence. The crux of the problem is scheduling the warp in a more reasonable order. Therefore, we propose a new warp scheduling strategy based on Multi-level Feedback Queue (MFQ) and Perceptron-Based Prefetch Filtering (PPF) called WSMP, where all the warps are sorted beforehand according to the latency tolerance of the warps and pushed into a certain queue in MFQ. We also remold PPF to enhance the modified underlying prefetcher. We are able to strike a balance between cache hit rate and prefetch coverage then. We verify its feasibility by GPGPU-Sim, along with exclusive GPGPU work-load. The results show that compared with baseline, WSMP improves IPC by 27.44% and reduces L2 cache miss rate by 8.53% on average.
Technology and clinician-learner interaction: How is the introduction of a new electronic health record expected to affect educational practice?
Authors: Caon Julianna , Eva Kevin W
Published: July 2022

IntroductionElectronic health records (EHRs) are increasingly common platforms used in medical settings to capture and store patient information, but very little has been published about how EHR implementation affects educational practice from the point of view of clinician-learner interactions. This research sought to examine how EHR implementation is anticipated to affect clinician-learner interactions and, in turn, impact upon educational priorities and outcomes. MethodsSemi-structured interviews were conducted with a group of practicing oncologists who work in outpatient clinics while also providing education to medical student and resident trainees. Data regarding perceived impact on the teaching dynamic between clinicians and learners were collected prior to implementation of an EHR. ResultsPhysician educators expected EHR implementation to influence the learning they themselves normally gain through teaching interactions as well as their engagement in teaching. Additionally, EHR implementation was expected to influence learners by changing what is taught, what is modelled, and their role in both clinical care and the educational dynamic. ConclusionUnderstanding the concerns clinicians have about EHR implementation both offers potential to enable changes to be made that could minimize disruptions caused by implementation and provides a foundation from which to assess actual educational impacts.
Impact of SARS-CoV-2-specific memory B cells on the immune response after mRNA-based Comirnaty vaccine in seronegative health care workers
Authors: Vallejo Alejandro , Vizcarra Pilar , Martín-Hondarza Adrián , Gómez-Maldonado Sandra , Haemmerle Johannes , Velasco Héctor , Casado José L.
Published: July 2022

Purpose
To analyze the impact of SARS-COV-2-specific memory B cells (MBC) on the immune response after two doses of mRNA-based Comirnaty COVID-19 vaccine in seronegative health care workers. This study is seeking a rationale for boosting vaccines.
Methods
Longitudinal study including 31 seronegative health care workers with undetectable MBCs (IgG-MBC- group), 24 seronegative with detectable MBCs (IgG-MBC + group), and 24 seropositive with detectable MBCs (IgG + MBC + group). The level of neutralizing, anti-S IgG, IgA, and IgM antibodies was quantified by ELISA. In addition, specific memory B and T cells were quantified by flow cytometry.
Results
The level of specific MBCs, and isotypes, in the IgG-MBC- group was lower compared to that found in IgG-MBC+ (p = 0.0001) and IgG + MBC+ (p < 0.0001) groups, respectively. Neutralizing and anti-S IgG antibodies were at lower levels in the IgG-MBC- group after the vaccine. Specific MBCs directly correlated with specific CD4 + T cells (although not significant, p = 0.065), while no correlation was found with specific CD8 + T cells (p = 0.156) after the vaccine. In parallel, neutralizing antibodies only positively correlated with specific CD4 + T cells (p = 0.034).
Conclusions
IgG-MBC- individuals showed the worst humoral and cellular responses, both in frequency and magnitude, after vaccine. Individuals whose antibodies wane and become undetectable after a given period of time post vaccine and show no specific MBCs are less protected and hence are good candidates for boosting vaccine. On the other hand, seronegative individuals with specific MBC showed faster and higher responses compared to the IgG-MBC- group.
Preferentially Expressed Antigen in Melanoma (PRAME) Expression Utility in Distinguishing Desmoplastic and Spindle Cell Melanomas from Malignant Peripheral Nerve Sheath Tumors
Authors: Hall Katie , Torrko Kathleen , Santiago Teresa , Clay Michael , Wisell Joshua
Published: July 2022

Spindle cell and desmoplastic melanoma (DM) are uncommon melanoma subtypes; both are composed of elongated “spindled cells” but differ from one another based on the extent of desmoplastic stroma separating individual tumor cells. These can be challenging lesions that often have absent or decreased staining for melanocyte specific markers and may resemble other tumors with spindle cell morphology and a similar immunohistochemical (IHC) staining profile, in particular malignant peripheral nerve sheath tumors (MPNSTs). We evaluated IHC expression of PRAME (Preferentially Expressed Antigen in Melanoma) in 41 DMs, 14 spindle cell melanomas, and 26 MPNSTs. PRAME expression was found in 68% of DM, 71% of spindle cell melanomas, and 84% of MPNSTs. However, when extent and intensity of expression are considered, significant differences emerge. The median H-score for all melanomas was 167.5 (range, 20 to 270) and 80 (range, 20 to 275) for all MPNSTs. Spindle cell melanoma, which often has the closest histologic appearance to MPNST, demonstrated the highest median H-score of 215 (range, 55 to 270). Furthermore, a strong and diffuse staining pattern was identified in 53% of all melanomas and 80% of spindle cell melanomas compared to strong, diffuse staining found in 29% of all MPNSTs and only 17% of MPNSTs with intact H3K27me3 expression.
Nidogen-1 Could Play a Role in Diabetic Kidney Disease Development: A Genome Wide Association Meta-analysis
Authors: Khattab Ahmed , Torkamani Ali
Published: July 2022

Background:Diabetic kidney disease (DKD) affects about 40% of patients with diabetes. It is uncurable and usually lead to end-stage renal disease (ESRD). The pathogenesis of DKD is still not fully understood and the genetics of DKD have not yet been extensively studied.In this study we investigate the genetic basis of DKD in type 2 diabetes (T2D) to provide more insights into the pathogenesis of the disease.Results:Using the data provided by the UK Biobank (UKBB), we performed a DKD genome-wide association study (GWAS) in 13,123 individuals with T2D as well as two creatinine estimated glomerular filtration rate (eGFR) GWA studies; one in 28,136 individuals with T2D and the other in 339,080 non-diabetic individuals. We also conducted a DKD GWAS meta-analysis combining our results with those published by the SUMMIT consortium.We confirm two loci previously reported to be associated with chronic kidney disease (CKD) and eGFR in T2D. The UMOD-PDILT locus is associated with DKD (P = 1.08E-09) as well as creatinine eGFR in both people with T2D (P = 5.35E-15) and people without diabetes (P = 2.06E-72). The PRKAG2 locus is associated with creatinine eGFR in people with (P = 6.22E-10) and without (P = 2.61E-72) T2D. Our meta-analysis reveals a novel association between DKD and variant rs72763500 (chr1:236116561) which is a splicing quantitative trait locus (sQTL) for nidogen-1 (NID1) gene.Conclusion:Our data confirms two loci previously reported in association with CKD and creatinine eGFR in T2D. It also suggests that NID1, a major component of the renal tubular basement membrane, could play a role in DKD development in T2D. While our NID1 finding remains to be replicated, it is a step towards a more comprehensive understanding of DKD pathogenesis.
Residual Risks of Comorbidities after Parathyroidectomy in a Nationwide Cohort of Patients with Primary Hyperparathyroidism
Authors: Kong Sung Hye , Kim Jung Hee , Park Man Young , Kim Sang Wan , Shin Chan Soo
Published: July 2022

Purpose: Primary hyperparathyroidism (PHPT) is a common endocrine disorder with increasing incidence, while epidemiologic data in Asian population has been lacking. Therefore, we aimed to identify the incidence, prognosis, and prognostic factors of PHPT patients who underwent parathyroidectomy in Korea. Methods: In this retrospective nationwide cohort, patients with PHPT were defined as those with diagnostic codes of PHPT and procedural codes for parathyroidectomy, excluding chronic renal failure or secondary hyperparathyroidism based on National Health Insurance Services database in Korea in 2002-2018. Main primary outcomes were all-cause mortality, cardiovascular, and cerebrovascular events. Results: A total of 5,561 patients were diagnosed with PHPT and had parathyroidectomy. The mean age was 54.5 years, and 71.8% were women. The age-standardized incidence was 10.1/ 100,000 person-year in 2018, rising from 1.7/100,000 person-year in 2002. During a mean of 5.9 years, history of cardiovascular disease, mood disorder, and genitourinary stone had increased risks of mortality with hazard ratios (HRs) of 1.59 (95% confidence interval [CI] 1.10-2.29), 1.43 (CI 1.14-1.80), and 1.40 (CI 1.09-1.80), respectively. History of hypertension, cerebrovascular disease, diabetes mellitus, and mood disorder were risk factors for cardiovascular events with HRs of 1.42 (CI 1.22-1.66), 1.29 (CI 1.05-1.58), 1.22 (CI 1.07-1.40), and 1.14 (CI 1.00-1.29), respectively. Mood disorder was a significant risk factor for cerebrovascular events (HR 1.30, CI 1.11-1.52). Conclusion: The incidence of PHPT patients who underwent parathyroidectomy has been rising in Korea as reported in other countries. Patients with complications, especially mood disorder, had increased cardiovascular and cerebrovascular events and mortality risks.
Effect of Target Detection on Recognition
Authors: Dong Yueqing , Meng Yingfang , Ye Zetong , Tang Yajun
Published: July 2022

To explore whether the effect of target detection on memory retrieval is associated with confounding factors and the internal cognitive mechanism and determine whether this difference originates from target detection or distraction inhibition, we conducted three experiments. In Experiment 1, we used target and distractor stimuli with meaningless stimuli and added the full attention (FA) condition as a baseline to compare with the distraction condition. The results showed that the correct identification of old words was significantly higher in target than in distractor trials. By contrast, the correct rejection rate of new words was significantly lower in target than in distractor trials. The correct identification rate of old words in distractor trials was significantly lower than the FA condition, as was the correct rejection rate of new words in target trials. In Experiment 2, the ratio of new to old words in the recognition task was adjusted to 1:1 to eliminate any reaction tendency related to the high ratio of old words. Finally, in Experiment 3, the word presentation time was extended to 1,500 ms or 3,000 ms (depending on the condition) to eliminate the risk of rapid processing in Experiment 1. In both cases, the results from Experiment 1 were replicated. This replication shows that the influence of target detection on recognition comes from both target detection and distraction rejection. Target detection influence on recognition may be due to yoking between the dual tasks.
Learning to Optimise a Swarm of UAVs
Authors: Duflo Gabriel , Danoy Grégoire , Talbi El-Ghazali , Bouvry Pascal
Published: July 2022

The usage of Unmanned Aerial Vehicles (UAVs) has shown a drastic increase of interest in the past few years. UAVs find applications where human action would be ineffective, slow, risky or even impossible. With a three-dimensional mobility and payload flexibility, they can indeed be used for missions like infrastructure inspection or search and rescue. Most applications have considered the usage of a single UAV so far, but using several autonomous UAVs as a swarm would overcome some drawbacks like mission duration (if one UAV of the swarm is out of battery, the latter can pause the mission while others keep flying) or payload capacity (the payload can be distributed among all UAVs). Designing an efficient swarm of UAVs however comes with some challenges, including the difficulty to define the necessary distributed algorithms to tackle specific tasks. The desired global behaviour, e.g. monitoring an area or transporting material, is indeed emergent from local interactions. Manually designing these local interactions can therefore be tedious and time-consuming.
This work thus aims at automating that process in the context of area coverage. The first step has been to define a multi-objective optimisation problem to represent an area coverage mission. The second step has been to define an algorithm to generate distributed heuristic for the latter optimisation problem. The proposed method is based on Q-learning and experimental results demonstrate that it permits to generate heuristics that not only outperform the state-of-the-art, but also provide a high stability.
2021 Asia Pacific Graves’ Disease Consortium Survey of Clinical Practice Patterns in the Management of Graves’ Disease
Authors: Parameswaran Rajeev , de Jong Mechteld C , Kit James Lee Wai , Sek Kathleen Sy , Nam Tran Quang , Thang Tran Viet , Khue Nguyen Thy , Aye Than Than , Tun Phone Myint , Cole Timothy , Miller Julie A , Villa Michael Lim , Khiewvan Benjapa , Sirinvaravong Sirinart , Sin Yong Li , Muhammad Rohaizak , Jap Tjin Shing , Agrawal Amit , Rajput Rajesh , Fernando Ranil , Sumanatilleke Manilka , Suastika Ketut , Shong Young Kee , Lang Brian , Bartalena Luigi , Yang Samantha Peiling
Published: July 2022

Aim
Although Graves’ disease (GD) is common in endocrine practices worldwide, global differences in diagnosis and management remain. We sought to assess the current practices for GD in countries across Asia and the Pacific (APAC), and to compare these with previously published surveys from North-America and Europe.
Methods
A web-based survey on GD management was conducted on a pool of practicing physicians. Responses from 542 eligible physicians were received and subsequently analysed and compared to outcomes from other, similar surveys.
Results
During initial work-up, majority of respondents would request thyroid-stimulating hormone (TSH; 73%) and free thyroxine assays (75%), as well as TSH-receptor autoantibodies (68%). Thyroid ultrasound would be requested by about half of respondents (53%), while the use of nuclear medicine scans was very limited. The preferred first-line treatment was antithyroid drug (ATD) therapy (79%) with methimazole (MMI) or carbimazole (CBZ), followed by radioiodine (RAI; 19%) and surgery (2%). In case of surgery, one-third of respondents would opt for a subtotal rather than a total thyroidectomy. In case of mild Graves orbitopathy (GO), ATDs (67%) remained the preferred treatment, but a larger proportion would prefer surgery (20%). For a patient with a pregnancy (wish), the overall preferred treatment pattern remained unchanged, although propylthiouracil (PTU) became the preferred ATD-agent during the first trimester. While on most issues choices of the physicians from APAC fell between European and American practices, marked differences were noted in the relatively infrequent usage of nuclear medicine scans and the overall higher concomitant use of a ATDs and β-blockers and adjunctive ATD-treatment during RAI.
Conclusion
Although regional differences regarding the diagnosis and management of GD are apparent in this first pan-Asia-Pacific survey, the overall approach to the management of this disease in APAC to generally fall between the trends appreciated in the American and European cohorts.
Spondylolisthesis and Mismatch Deformity Affect Outcomes after Total Knee Arthroplasty
Authors: Sheppard William L. , Chiou Daniel , Upfill-Brown Alexander , Shah Akash , Edogun Eghosa , Sassoon Adam A. , Park Don Y.
Published: July 2022

Background
Little published data currently exist regarding the potential relationships between spondylolisthesis, mismatch deformity and clinical outcomes following total knee arthroplasty (TKA). We hypothesize that pre-existing spondylolisthesis will result in decreased functional outcomes after TKA.
Methods
This retrospective cohort comparison of 933 TKAs was performed between January 2017–2020. TKAs were excluded if they were not performed for primary osteoarthritis (OA) or if preoperative lumbar radiographs were unavailable/inadequate to measure the degree of spondylolisthesis. 95 TKAs were subsequently available for inclusion and divided into two groups: those with spondylolisthesis and those without. Within the spondylolisthesis cohort, pelvic incidence (PI) and lumbar lordosis (LL) were calculated on lateral radiographs to determine the difference (PI-LL). Radiographs with PI-LL > 10° were then categorized as having mismatch deformity (MD). The following clinical outcomes were compared between the groups: need for manipulation under anesthesia (MUA), total postoperative arc of motion (AOM) both pre-MUA or post-MUA/revision, incidence of flexion contracture, and a need for later revision.
Results
49 TKAs met the spondylolisthesis criteria, while 44 did not have spondylolisthesis. There were no significant differences in gender, body-mass-index (BMI), preoperative knee range of motion (ROM), preoperative AOM, or opiate use between the groups. TKAs with spondylolisthesis and concomitant MD were more likely to have MUA (p = 0.016), ROM < 0-120 (p < 0.014), and a decreased AOM (p < 0.02) without interventions.
Conclusion
Pre-existing spondylolisthesis by itself may not have adverse effect clinical results following TKA. However, spondylolisthesis increases the likelihood of developing MD. In those with both spondylolisthesis and concomitant mismatch deformities, patients had statistically and clinically significantly decreased in post-operative ROM/AOM and increased need for MUA. Surgeons should consider clinical/radiographic assessments of patients with chronic back pain who present for total joint arthroplasty.
Child maltreatment exposures and adolescent nonsuicidal self-injury: The mediating roles of difficulty in emotion regulation and depressive symptoms
Authors: Hu Changchun , Huang Jialing , Shang Yushan , Huang Tingting , Jiang Wenhao , Yuan Yonggui
Published: July 2022

Background: Although child maltreatment (CM) experiences are recognized risk factors for Nonsuicidal self-injury (NSSI), the mechanisms underlying this relationship remain unclear. The purpose of this study was to examine if difficulty in emotion regulation (DER) and depressive symptoms mediate between child maltreatment experiences and NSSI severity, adjusting for demographic variables.Method: Participants were 224 adolescent inpatients recruited from a hospital in China (mean age 15.30 years, SD=1.83; 78.6% females). Study measures included Clinician-Rated Severity of Nonsuicidal Self-Injury (CRSNSSI), Childhood Trauma Questionnaire (CTQ-SF), Difficulties in Emotion Regulation Scale (DERS), and Patient Health Questionnaire-9 (PHQ-9). The hypothesized chain mediation model was tested using the structural equation model.Results: 146 (65.18%) adolescents reported engaging in NSSI during the past 12 months and 103 (45.98%) participants met the DSM-5 diagnostic criteria for NSSI. emotional neglect (48.1%) and emotional abuse (46.1%) had the highest prevalence, followed by physical neglect (43.1%) and physical abuse (24.1%) and sexual abuse (12.5%) was the least prevalent form of CM. The DER or depressive symptoms significant-ly mediated the association between CM and NSSI, DER was the strongest mediator with an indirect effect of 49.40% (p=0.014). At the same time, we also proved a potential chain-mediated pathway of DER and depression between CM and NSSI.Conclusion: Child Maltreatment and NSSI are indeed, common among Chinese psychiatric patients. DER may be an important proximal mechanism linking CM and adolescent NSSI, but not depressive symp-toms, findings from the study have implications for preventing and treating NSSI in youth with CM history.
Where are the vulnerable children? Identification and comparison of clusters of young children with health and developmental vulnerabilities across Queensland
Authors: Areed Wala Draidi , Price Aiden , Arnett Kathryn , Mengersen Kerrie , Thompson Helen
Published: July 2022

Background: Developmental vulnerabilities within children in Queensland have a variety of domains; these domains measure the development of children in their first five years. It is crucial to understand how these domains are grouped, or clustered, with respect to population risk factor profiles. These groups inform policy implementation, which can help to provide assistance to the most vulnerable children across Queensland. Methods: K-means analysis was conducted on data from the Australian Early Development Census and the Australian Bureau of Statistics. The clusters were then compared with respect to their geographic locations and risk factor profiles. The results are presented in this paper and are publicly available via an interactive dashboard application in R Shiny. Results: This study presents a comprehensive clustering analysis for child development vulnerability domains in Queensland. In addition, all of the clustering analyses reveal a strong relationship between developmental vulnerability and socio-economic and remoteness factors. In addition, we found that children who attend preschool and whose primary language is English are, in most cases, in the lowest developmental vulnerability cluster. Conclusion: In this study, the performance of the K-means clustering algorithm has been developed to study the clusters inside child development vulnerabilities when analysing the data at the small area level. Further, R shiny application was created, and the feature of the risk factors in each region was studied.
Edible composition of different finfishes imported by the Kingdom of Saudi Arabia from certain Asian and Arab countries
Authors: Jannathulla R.
Published: July 2022

Edible composition of different finfishes viz., Grouper, Rabbitfish, Parrotfish, Catfish, Emperor, Tilapia, Milkfish, Sea bream and Sea bass imported by Saudi Arabia from certain Asian and Arab countries was evaluated in the present study. The statistical analysis of one-way ANOVA revealed that the moisture content varied (p < 0.05) from 65.03–87.27%. Catfish had the highest value of moisture (87.24%) and the least value was noticed in Sea bream (65.03%). Tilapia, Emperor and Milkfish had the highest (p < 0.05) crude protein (21.39–21.77%) followed by Sea bass, Grouper and Parrotfish (19.34-21.012%). The level of crude lipid was drastically high (p < 0.05) in Sea bream (17.08%) compared to all other species (0.31–6.63%). The total ash content was relatively similar in all the fishes and was > 1.2%, except Sea bream (0.96%). There was no significant difference in total carbohydrates among the fishes analyzed. Sea bream showed the highest gross energy (2563.11 Cal/g), while the least value was found in Catfish (692.02 Cal/g). The daily values of protein for all the fishes were grouped under the category of very good (22.28–47.11%) and it was poor for lipid in all the fishes (0.40–8.51%), except Seabream (21.91%). Results conclude that all the analyzed fishes have own nutritional characteristics and all are found to be good sources of nutrients.
The Association between Disability and Psychological Distress in Carpal Tunnel Syndrome Patients with Extraterritorial Symptoms
Authors: Habbal Aya Al , Alsharif Aya , Hawat Lama Al , Daaboul Yaman , Kakaje Ameer
Published: July 2022

Background and Aims: Carpal tunnel syndrome (CTS) is a median nerve neuropathy that classically causes symptoms along the median nerve distribution. However, extraterritorial symptoms are common and associated with more severe pain. Therefore, assessing the disability caused and its association with psychological distress is crucial. This paper aims to discover the degree of psychological distress, disability, and upper extremity symptoms that CTS patients with extraterritorial symptoms experience and the correlation between disability, psychological distress, and nerve conduction studies (NCS). Methods:This cross-sectional study was conducted in a neurophysiology outpatient clinic. Participants were patients diagnosed with CTS with extraterritorial symptoms. Data were collected during interviews using Quick Disabilities of Arm, Shoulder & Hand (QuickDASH), Hospital Anxiety and Depression Scale (HADS), Dimensions of Anger Reactions scale-5 (DAR-5), and NCS.Results: This study included 171 patients. CTS patients with extraterritorial symptoms demonstrated 44.4% disability with 50.9% severe to extreme pain, borderline abnormal anxiety and depression, and problematic anger. There was a significant positive correlation between disability level and anxiety, depression, and anger (p<0.05). However, no significant correlation between disability and NCS was found (p>0.05). The work-related disability had a significant correlation with anxiety and depression but no correlation with anger. Interpretation: This study opens the door for future studies to test the contribution of psychological factors to the spread of extraterritorial symptoms as a part of other mechanisms discussed by previous studies.
Evaluation of a continuous glucose monitor-derived homeostasis metric for type 2 diabetes screening
Authors: Kaufman Jaycee , Veen Lenneart van , Fossat Yan
Published: July 2022

Effective intervention for Type 2 Diabetes relies heavily on early detection. However, a majority of people with early-onset diabetes are not aware of their condition and are likely to consult with a physician only when their homeostatic control of blood sugar levels is irreparably damaged. Thus, there is a growing demand for screening tools that can easily be integrated into routine check-ups and do not require changes in daily routine and diet, doctor consults or laboratory analysis of blood samples. The screening tool we propose here is based on data gathered from Continuous Glucose Monitors and on a model of the blood glucose level as a function of glucose intake and the dynamics of the feedback control. We calibrate the method using data from a clinical trial with subjects diagnosed by a physician (n=123) and validate it on a larger follow-up study (n=270). Here we show that the sensitivity of the proposed test is on par with that of the HbA1c criterion and exceeds that of the Oral Glucose Tolerance Test.
MODERN PARADIGMS OF CORPORATE CULTURE FORMATION AS AN EFFECTIVE PERSONNEL MANAGEMENT TOOL
Authors: Diakonova І. , Dolhosheieva O. , Ivanova L. , Sinyagovsky Yu. , Vasiukova V.
Published: July 2022

The article highlights the main provisions of corporate culture role in business system human resource management. It is determined, that human resource management is aimed at maximum adaptation and disclosure of human potential, taking into account the positive social and economic effect for the company. The result of human resource management is expressed in the effectiveness of human capital attracting. An analysis of the approaches to human resource management covered in the scientific literature found, that today many people have an approach to human resource management, which contains four concepts and is developed in accordance with three main approaches to human resource management.
During the study of approaches to human resource management in modern conditions of economic relations, it was found that one of the areas of providing companies with qualified personnel is the development and implementation of policies in the field of training and development of their own personnel. In this case, the leaders of the organization will have the opportunity to get highly qualified, motivated and creative professionals from among their employees, who will be ready to bring new approaches to the company's business processes that meet the mission and objectives of its operation.
Another area of providing the company with professional staff is the formation of an effective recruitment system, which is a set of measures to find and select the necessary specialists for the organization. Modern human resource professionals use a variety of techniques and the latest advances at every stage of their work to develop the company and improve the human resource management system, taking into account that personal qualities of the employee mainly affect his behavior in the organization and performance of professional and social roles in the team.
The paper contains proposals for improving approaches to the formation and implementation of corporate culture as an effective tool for human resource management in terms of the main trends in post-industrial society and models of new technologies and tools development. Such tools can also be called Headhunting, HR-brand, social networks, remote or automatic selection.
PARTICIPATORY BUDGET AS A TOOL OF TERRITORIAL UNIT ENGAGEMENT IN DECISION-MAKING IN PUBIC ADMINISTRATION: PROJECT MANAGEMENT IN ACTION
Authors: Shvindina H. , Sheremet M. , Yevtushenko V. , Antonenko A. , Nereta G.
Published: July 2022

Research by the Massachusetts Institute of Technology (MIT) proves that democratic societies are richer than others; moreover, democratization leads to the economic development of countries as a whole, even if not all areas are engaged in the reforms. This study contrasts paternalism as the parental behavior of any hierarchical system that violates the freedoms and personal autonomy of individuals (groups); and participatory governance, which aims to involve individuals in the decision-making system at various levels. First introduced in 1989 in Porto Alegre, Brazil, the participatory budget (hereinafter PB) has since been adopted in many regions, both in the European Union and worldwide, with communities in Ukraine starting to implement PB in 2015. Sumy territorial unit joined this process in 2017. Only three years' results (except for 2020 through COVID-19) are not enough to analyze certain patterns; however, this study identified some positive changes and barriers to the development of PB, which may be the starting point for further research in this area.
This study identified the main trends - reducing the submission and funding of projects in 2021 after a one-year break (due to the pandemic situation), increasing the number of women authors (up to 63%), the invariability of the categories for which projects are submitted. Thus, the leaders in the field are projects dedicated to the healthy lifestyle and city beautification, followed by projects in culture and tourism, and education. To date, 21 projects have been implemented in Sumy within the framework of the PB. At the same time, the problems of further development of participatory budgeting remain unresolved, such as the complexity of the procedure for submitting, defending and implementing the project, low quality of support of authors during the project implementation and others. The introduction of educational courses in project management at the expense of the budget will not solve all problems, but will increase the level of public involvement in PB in the future, which is especially important in terms of population decline in general.
THE IMPACT OF TERRITORIES TRANSFORMATIONAL PROCESSES ON MARKETING COMMUNICATIONS DEVELOPMENT: BIBLIOMETRIC ANALYSIS
Authors: Nesterenko V. , Jasnikowski А. , Rosohata А. , Koroshchenko V.
Published: July 2022

The work aims to systematize scientific knowledge on the transformational processes in marketing development. The objectives of the work are to understand the content and characteristics of existing research on transformational processes, connection with marketing processes, and to identify areas of research in recent years. The articles on transformational processes in the Web of Science database were selected in the first stage. More than 4,000 publications were initially selected for these queries ‘transformational processes’ in the Web of Science database. Only articles published in English from 2017 to 2021 inclusive were left. It was founded 1789 articles. An analysis of the most cited publications on transformation processes was conducted. Hierarchical cluster analysis was performed based on keywords. Visualization of scientific literature topics was carried out with the help of the VOSviewer program. As a result of cluster analysis, 7 clusters were identified on transformation processes: economic and social, health and educational transformations; behavioral features; innovations; people at work; leadership and organization changes; team climate and workplace; behavioral factors, job characteristics, and motivation. Most of the clusters relate to enterprise activities and marketing activities, in particular on competitive advantages, creativity, innovation, market orientation, product development, service, SMEs, corporate social responsibility, customer orientation, and others. The results of this study may be useful to researchers and practicing marketers to develop long-term marketing programs focused on current trends.
Sugar and Proline Accumulation in Grapefruit Flavedo and Leaves during Cold Hardening of Young Trees1
Authors: Purvis A. C. , Yelenosky G.
Published: July 2022

Four-year-old ‘Marsh’ grapefruit (Citrus paradisi Macf.) trees on trifoliate orange [Poncirus trifoliata (L.) Raf.] rootstock were temperature acclimated to 5°C in controlled environment facilities with approximately 400 μeinsteins m−2s−1 PAR. Total soluble carbohydrates and proline increased in both leaves and fruit flavedo as temperatures were progressively decreased. Maximum accumulation of carbohydrates occurred in leaves and flavedo at 10° ambient air. Both sucrose and reducing sugars increased in leaves at all acclimating temperatures, but only reducing sugars increased in the flavedo at temperatures below 15°. The concentration of proline was the greatest in the leaves and flavedo at 5°. Both total soluble carbohydrates and proline decreased during temperature deacclimation at 25°.
The Influence of Irrigation and Row Spacing on the Quality of Processed Snap Beans1
Authors: Drake S. R. , Silbernagel M. J.
Published: July 2022

Irrigation method and row spacing had a significant influence on the quality of fresh, canned, and frozen snap beans (Phaseolus vulgaris L.). Sprinkle irrigated fresh and canned snap beans contained more ascorbic acid than rill irrigated snap beans. Rill irrigated snap beans had more intense color, lower shear values, less turbid brine, and less drained weight loss. Canned snap beans grown in narrow rows had less drained weight loss than snap beans from wide rows. Frozen snap beans from narrow rows had more drip loss, less moisture, increased soluble solids, and increased ascorbic acid content than those from wide rows. Under the conditions of this study, rill irrigated snap beans and snap beans grown in narrow rows did have quality advantages over sprinkle irrigated snap beans and snap beans grown in wide rows.
Response of Bush Snap Beans (Phaseolus vulgaris L.) to Irrigation and Plant Density1
Authors: Mack H. J. , Varseveld G. W.
Published: July 2022

Yields of snap bean pods were increased by irrigation and plant density in 4 field experiments. Highest yields were obtained with the −0.6 bar soil water potential regime which represented removal of 40-45 percent of the available soil water at 30 cm depth. Yields were lowest with the −2.5 bars soil water potential which represented 65-70 percent water removal. An average of 60 percent more water applied to the −0.6 bar than the −2.5 bars treatment increased yields approximately 54 percent. Yields were usually intermediate with the −1.0 bar soil water potential representing 50-55 percent available soil water removal. Two cultivars were used in 2 of the experiments and responded differently to irrigation. Yield of ‘Oregon 1604’ was higher than that of ‘Galamor’ with −0.6 bar soil water potential but was lower than ‘Galamor’ with −2.5 bars. Yield of ‘Oregon 1604’ averaged 27 percent higher in square arrangement than in 91 cm rows and the increase was greater for the high than for the low population density when compared in 1 experiment. Yield was 20 percent higher for high density of 43.0 plants/m2 than for low density of 21.5 plants/m2. Yields of 2 cultivars in 2 experiments averaged 67 percent higher in high density (40-57 plants/m2) than in low density (20-33 plants/m2) plantings. There were no consistent irrigation × density interactions. Usually there was a more rapid depletion of soil water for high density than for low density. Fiber in canned sieve size 5 pods was higher in ‘Oregon 1604’ at −2.5 bars soil water potential than for ‘Galamor’, but at the −0.6 bar soil water potential regime, the amount of fiber was similar in the 2 cultivars. Percent of pod weight attributed to seed and percent fiber were usually highest at −2.5 soil water potential.
Growth Responses of Seed Geranium and Petunia to N Source and Growing Media1
Authors: Schrock Patricia A. Tew , Goldsberry Kenneth L.
Published: July 2022

Pelargonium hortorum (Bailey) ‘Sprinter Scarlet’ and Petunia hybrida (Bailey) ‘Candy Apple’ seedlings were grown in 2 media and watered with 5 nutrient solutions containing varying ratios of NO3−:NH4+, each resulting in a total NO3− plus NH4+ concentration of 15 meq liter−1. There were no significant differences in height, fresh and dry weights, or number of vegetative breaks in soil-grown plants due to the N forms. Plant growth in the soilless medium was substantially reduced as the proportion of NH4+ increased above 50%.
Nitrogen Movement Comparisons in Cropped versus Fallowed Soils1
Authors: Boswell Fred C. , Anderson O. E.
Published: July 2022

The movement and accumulation patterns of N, applied as KNO3 to cropped and fallowed plots, were studied on two widely different soils, Marlboro and Davidson. Generally, the movement and accumulation patterns indicated movement of N to a greater depth and extent on the cropped than on fallowed plots. Nitrogen movement in the Marlboro surface and subsoil was considerably greater than in Davidson soil. Even with excessive rainfall, most of the N recovered 11 to 12 months after application was concentrated between the 46 to 122‐cm depths with the largest accumulation occurring in the 61 to 91‐cm layer. After 10 weeks and 29 cm of rainfall, 78% of the applied N was recovered on the fallowed Davidson soil while after 50 weeks and 154 cm of rainfall 53% was recovered. Comparable recoveries for the cropped plots were 89 and 49% respectively. After 5 weeks and 12 cm rainfall, the recovery on the fallowed plots of the Marlboro soil was 109% but had decreased to 33% after 46 weeks and 124 cm of accumulated rainfall. Data for cropped plots indicated 119 and 25% recovery for the respective sampling periods. Recovery increased approximately 5 to 10% on the cropped plots when the plant N uptake values were included.
Soil Moisture Effects on Root Growth and Phosphorus Uptake by Corn1
Authors: Mackay A. D. , Barber S. A.
Published: July 2022

While the effects of soil moisture and P level on corn (Zea maysL.) root growth and P uptake have been measured, the extent each of the mechanisms involved in P uptake is affected by soil moisture has not been determined. The objective of this study was to investigate the effect of soil moisture on each of the parameters used in a mechanistic mathematical model to predict P uptake by corn. The effect of volumetric soil moisture, 0.22 (M0), 0.27 (M1), and 0.32(M2), the water held at potentials of −7.5, −33, and −170 kPa, respectively, and three soils (S0and S1, Raub, fine‐silty, mixed, mesic Aquic Argiudolls and S2, Chalmers, fine‐silty, mixed, mesic Typic Haplaquolls, silt loams) obtained from plots having different longtime P histories, on root growth and P uptake by corn was investigated in a series of pot experiments in a controlled climate chamber. As soil moisture was raised from M0to M1, total plant weight increased by 13 to 43%, total P uptake by corn increased by 55 to 70%, and corn root length increased 41 to 52% with the three soils for measurements made at 28 days. Raising soil moisture content further from M1to M2, in contrast, decreased total plant weight by an average of 13%, total P uptake by an average of 15%, and root length by an average of 16% at 21 days. Root surface area and mean P influx, which both increased as soil P increased, were correlated with P uptake. These correlations suggest that increasing soil P increases P uptake, both by increasing P influx and root growth. Raising soil moisture from M0to M1increased P uptake by increasing root growth. Soil moisture did not significantly (P<0.05) affect P influx. Using data for three moisture levels on three soils, predicted P uptake (y) in µmol pot−1calculated with the simulation model for corn grown for 7, 14, and 21 days agreed with observed P uptake (x) (y= 0.78x+ 10.93; r= 0.975**, significant at the 0.01 level).
Laboratory Bioassay for Phytotoxicity
Authors: Al Hamdi Bader , Inderjit  , Olofsdotter Maria , Streibig Jens C.
Published: July 2022

Allelopathy involves complex plant × plant chemical interactions. Although a large number of laboratory bioassays have proposed to demonstrate allelopathy, most of them have little or no relevance in terms of explaining behavior in the field. In this paper, we discuss the phytotoxicity of wheat (Triticum aestivum L.) straw leachate to the seedling growth of perennial ryegrass (Lolium perenne L.). The objective of this study was to discuss the significance of (i) soil, (ii) leachate concentrations in bioassays of plant debris and soil, (iii) the role of N fertilizer in overcoming plant growth inhibition, (iv) organic molecules in plant inhibition, and (v) actual assay species. The results show the phytotoxic nature of wheat straw leachate (WSL) and the possible involvement of organic molecules in the growth inhibition of perennial ryegrass. However, laboratory studies can not demonstrate allelopathy as the sole factor responsible for the observed growth inhibition.
Singular‐Value Partitioning in Biplot Analysis of Multienvironment Trial Data
Authors: Yan Weikai
Published: July 2022

Multienvironment trials (MET) are conducted every year for all major crops throughout the world, and best use of the information contained in MET data for cultivar evaluation and recommendation has been an important issue in plant breeding and agricultural research. A genotype main effect plus genotype × environment interaction (GGE) biplot based on MET data allows visualizing (i) the which‐won‐where pattern of the MET, (ii) the interrelationship among test environments, and (iii) the ranking of genotypes based on both mean performance and stability. Correct visualization of these aspects, however, requires appropriate singular‐value (SV) partitioning between the genotype and environment eigenvectors. This paper compares four SV scaling methods. Genotype‐focused scaling partitions the entire SV to the genotype eigenvectors; environment‐focused scaling partitions the entire SV to the environment eigenvectors; symmetrical scaling splits the SV symmetrically between the genotype and the environment eigenvectors; and equal‐space scaling splits the SV such that genotype markers and environment markers take equal biplot space. It is recommended that the genotype‐focused scaling be used in visualizing the interrelationship and comparison among genotypes and the environment‐focused scaling be used in visualizing the interrelationship and comparison among environments. All scaling methods are equally valid in visualizing the which‐won‐where pattern of the MET data, but the symmetric scaling is preferred because it has all properties intermediate between the genotype‐ and the environment‐focused scaling methods.