bluuebunny/crossref_metadata_2025 huggingface dataset:
Rad51 Silencing with siRNA Delivered by Porous Silicon-Based Microparticle Enhances the Anti-Cancer Effect of Doxorubicin in Triple-Negative Breast Cancer
Authors: Wu Zeliang , Zhu Lin , Mai Junhua , Shen Haifa , Xu Rong
Published: January 2022

Due to its high heterogeneity and aggressiveness, cytotoxic chemotherapy is still a mainstay treatment for triple negative breast cancer. Unfortunately, the above mentioned has not significantly ameliorated TNBC patients and induces drug resistance. Exploring the mechanisms underlying the chemotherapy sensitivity of TNBC and developing novel sensitization strategies are promising approaches for improving the prognosis of patients. Rad51, a key regulator of DNA damage response pathway, repairs DNA damage caused by genotoxic agents through “homologous recombination repair.” Therefore, Rad51 inhibition may increase TNBC cell sensitivity to anticancer agents. Based on these findings, we first designed Rad51 siRNA to inhibit the Rad51 protein expressionin vitroand evaluated the sensitivity of TNBC cells to doxorubicin. Subsequently, we constructed discoidal porous silicon microparticles (pSi) and encapsulated discoidal 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) liposomes/siRad51 (PS-DOPC/siRad51) to explore the synergistic antitumor effects of siRad51 and doxorubicin on two mouse models of TNBCin vivo.Ourin vitrostudies indicated that siRad51 enhanced the efficacy of DOX chemotherapy and significantly suppressed TNBC cell proliferation and metastasis. This effect was related to apoptosis induction and epithelial to mesenchymal transition (EMT) inhibition. siRad51 altered the expression of apoptosis- and EMT-related proteins. In orthotopic and lung metastasis xenograft models, the administration of PS-DOPC/siRad51 in combination with DOX significantly alleviated the primary tumor burden and lung metastasis, respectively. Our current studies present an efficient strategy to surmount chemotherapy resistance in TNBC through microvector delivery of siRad51.
Drug-Free Liposomes Containing Mannosylated Ligand for Liver-Targeting: Synthetic Optimization, Liposomal Preparation, and Bioactivity Evaluation
Authors: Chen Jing , Lin Yuan , Wu Min , Li Chuangnan , Zhang Yimin , Chen Dongpeng , Cheng Yi
Published: January 2022

This research was performed to optimize the enzymatic synthesis of mannosylated ligand with which to prepare mannosy-lated liposomes and investigate their bioactivity. Based on single-factor studies, lipase dose, substrate molar ratio (diester lauric diacid-cholesterol to mannose) and
temperature were identified as significant parameters, and optimal reaction conditions were determined through response surface methodology (RSM) with central composite design. The optimum operating parameters, 61.23 mg of lipase, a substrate molar ratio of 5.36, and 56.64 °C temperature
offered a predicted yield (71.11%) which was consistent with the actual yield (69.08%). Drug-free mannosylated liposomes were prepared film-dispersion. The characterizations of these liposomes showed that mannosylated liposomes were well-dispersible spherical particles with an average particle
size of 142.3 nm, the polydispersity index of 0.16, and a zeta potential of −19.8 mV. Pyrogen examination, hemolytic studies and cytotoxicity assays revealed no substantial safety concern for drug-free mannosylated liposomes. Cellular uptake efficiency of mannosylated liposomes by HepG2
cells was significantly higher than that of unmodified liposomes, demonstrating that mannosylated ligands have a positive effect on liver targeting. Overall, mannosylated liposomes could be active drug delivery system for combatting the therapy of hepatic diseases.
Highly Sensitive Electrochemical Aptasensor for Detection of Glypican-3 Using Hemin-Reduced Graphene Oxide-Platinum Nanoparticles Coupled with Conductive Reduced Graphene Oxide-Gold Nanoparticles
Authors: Li Guiyin , Li HaiMei , Chen Wei , Chen Huijiang , Wu Guanxiong , Tan Mingxiong , Liang Jintao , Zhou Zhide
Published: January 2022

An electrochemical aptasensor for quantitatively detecting glypican-3 (GPC3) was constructed by combining hemin-reduced graphene oxide-platinum (H-rGO-Pt) nanoparticles (NPs) with reduced graphene oxide-gold (rGO-Au) nanoparticles (NPs). Herein, the rGO-Au NPs deposited onto screen-printed
electrodes resulted in signal amplification due to their large surface areas. Meanwhile, highly conductive H-rGO-Pt NPs acted as a sensing medium that improved electrical conductivity and as an indicator for monitoring peak current for determination. A GPC3 aptamer (GPC3apt) with a low equilibrium
dissociation constant was used as a bio-recognition molecule. GPC3apt specifically captured GPC3 proteins and formed aptamer-GPC3 complexes, which impeded electron transfer and thus hampered the redox signal of hemin in H-rGO-Pt NPs. This developed electrochemical aptasensor showed a linear
response to GPC3 (from 0.001 μg/mL to 10 μg/mL) and had a detection limit of 0.001 μg/mL. This work provides a low-cost and highly sensitive detection with and good recovery for GPC3 and holds great promise for the clinical diagnosis of hepatocellular carcinoma.
An Evaluation of the Factors Affecting Failure of the Procedure in Reoperated Thyroidectomies: A Retrospective Analysis
Authors: Çomçalı Bülent , Özdemir Buket A. , Ataş Hakan , Özdemir Egemen , Tikici Deniz , Saylam Barış
Published: January 2022

Background

The aim of this study was to determine the factors affecting procedure failure in revision thyroidectomy surgery.

Methods

A total of 148 patients applied with revision surgery were separated into 2 groups according to the surgical success status. Comparisons were made of the 2 groups of patients where residual tissue was totally excised (Group 1, n:132) and patients where residual tissue could not be completely excised (Group 2, n:16). The patients were examined in respect of factors affecting the success of the procedure.

Results

The patients comprised 133 (89.9%) females and 15 (10.1%) males with a mean age of 49.68±12.02 years. Surgical failure was observed in 7 patients as the lesion could not be determined despite the use of intraoperative USG, and in 9 patients because of weak signal or signal loss. The determination of residual tissue ≤25mm on preoperative USG examination was seen to have a significant negative effect on surgical success (r=-0.329, p0.001). The patient having undergone ≥3 previous operations was determined to have a negative effect on surgical success (r=-0.229, p=0.005), and nerve damage on the opposite side to the lesion in a previous surgical procedure was determined to be the most important factor with a negative effect on surgical success (r=-0.571, p<0.001). In multinomial logistic regression analysis of the factors affecting success, the preoperative presence of nerve damage in the contralateral lobe to the lesion (OR: 33.11, 95% CI: 4.22-192.28, p<0.001) and lesion size ≤25 mm (OR: 10.10, 95% CI: 3.54-75.01, p=0.001) were determined to contribute significantly to surgical failure.

Conclusion

The results of this study clearly showed that as residual tissue size ≤25mm and contralateral nerve damage in the preoperative ultrasonographic evaluation are associated with surgical failure, alternative treatment methods such as radioactive iodine ablation may be preferred in these patients.
Trauma Surgeon-Led and Funded Injury Prevention Program Decreases Number of All-Terrain Vehicle-Related Admissions
Authors: Holt Matthew F. , Fortmann Joshua , Testerman George M.
Published: January 2022

Background

All-terrain vehicle (ATV) laws regarding helmet use, alcohol involvement, and roadway riding are poorly enforced or largely ignored. We hypothesized that direct surgeon funding and leadership in injury prevention would decrease ATV crashes. To focus prevention efforts, we reviewed a rural level 1 trauma center 11-year experience with ATV crashes comparing helmeted and unhelmeted rider outcomes.

Methods

For the latter 6 years of the study period, a trauma surgeon sponsored an injury prevention fund promoting ATV safety using simulators and discussions for area high school students. Helmet use, alcohol avoidance, and safe ATV operating were emphasized. A trauma registry review of ATV admissions from 2009 through 2020 examined demographics, helmet use, and clinical outcomes using chi-square, t-test, and regression analysis.

Results

Unhelmeted ATV riders suffered more severe head and neck injuries (OR 19, CI 1.5-1.8, P < .001), worse overall Injury Severity Score (ISS), (OR 25, CI 12.1-14.2, P < .001), and higher mortality rates (OR 4.0, CI .02-.05, P < .001). Helmet use corresponded with an average decrease in AIS and increase in GCS status. Although only 15% of riders were helmeted, ATV crash admissions have decreased in the last 5 years ( P < .001).

Discussion

All-terrain vehicle trauma and mortality is still frequent, especially in unhelmeted riders. The recent decrease in area ATV crashes is encouraging. Trauma surgeons have an opportunity to make a difference in public awareness and education through comprehensive physician-funded and directed injury prevention and research efforts.
Risk Factors of Mortality in Patients Hospitalized With Chronic Duodenal Ulcers
Authors: Lin Nicole , Smiley Abbas , Goud Manoj , Lin Cynthia , Latifi Rifat
Published: January 2022

Background

We aimed to identify risk factors of mortality in patients hospitalized with duodenal ulcers (DUs).

Methods

A National Inpatient Sample–based retrospective cohort study from 2005 to 2014 was conducted on patients undergoing emergency admission for chronic DUs. Demographics, clinical data, and outcomes were collected. Multivariable logistic regression model was applied to find the risk factors of mortality.

Results

70 641 patients were included in this study, of which 30 525 (43%) were non-elderly (< 65 years) and 40 116 (57%) were elderly (65+ years) patients. 72% of non-elderly and 57% of elderly patients were males. Mortality rate of men vs women was similar in non-elderly group (1.9% vs 2%, respectively), whereas it significantly differed in elderly patients (4.5% vs 5.3%, respectively, P<.0001). Time to operation was 1.15 (1.83) days in survived vs 1.55 (3.86) days in deceased non-elderly patients ( P < .001). Time to operation was .85 (1.73) days in survived vs 1.79 (7.28) days in deceased elderly patients ( P < .001). In patients with operation, age, delayed operation, frailty, and presence of perforation were the main risk factors of mortality in both elderly and non-elderly patients. Invasive diagnostic procedure was shown as a protective factor in elderly patients. In the final model for patients with no operation, age, hospital length of stay, and frailty were the main risk factors of mortality in both elderly and non-elderly patients. Invasive diagnostic procedure was revealed as a protective factor in all patients as well.

Conclusion

Early operation in patients with DU requiring surgical intervention is essential to improve the outcomes.
How Did the COVID-19 Pandemic Affect Trauma Volume at an Urban Level I Trauma Center?
Authors: Hahn Alexandra , Brown Tommy , Chapman Brett , Marr Alan , Stuke Lance , Greiffenstein Patrick , Schoen Jonathan , Hunt John P. , Smith Alison
Published: January 2022

Introduction

The COVID-19 pandemic changed the face of health care worldwide. While the impacts from this catastrophe are still being measured, it is important to understand how this pandemic impacted existing health care systems. As such, the objective of this study was to quantify its effects on trauma volume at an urban Level 1 trauma center in one of the earliest and most significantly affected US cities.

Methods

A retrospective chart review of consecutive trauma patients admitted to a Level 1 trauma center from January 1, 2017 to December 31, 2020 was completed. The total trauma volume in the years prior to the pandemic (2017-2019) was compared to the volume in 2020. These data were then further stratified to compare quarterly volume across all 4 years.

Results

A total of 4138 trauma patients were treated in the emergency room throughout 2020 with 4124 seen during 2019, 3774 during 2018, and 3505 during 2017 in the pre-COVID-19 time period. No significant difference in the volume of minor trauma or trauma transfers was observed ( P < .05). However, there was a significant increase in the number of major traumas in 2020 as compared to prior years (38.5% vs 35.6%, P < .01) and in the volume of penetrating trauma (29.1% vs 24.0%, P < .01).

Discussion

During the COVID-19 outbreak, trauma remained a significant health care concern. This study found an increase in volume of penetrating trauma, specifically gunshot wounds throughout 2020. It remains important to continue to devote resources to trauma patients during the ongoing COVID-19 pandemic.
Independent Predictors of In-Hospital Mortality in Elderly and Non-elderly Adult Patients Undergoing Emergency Admission for Hemorrhoids
Authors: Levy Lior , Smiley Abbas , Latifi Rifat
Published: January 2022

Background

The study explored determinants of mortality of admitted emergently patients with the primary diagnosis of hemorrhoids, during the years 2005-2014.

Methods

Demographics, clinical data, and outcomes were obtained from the National Inpatient Sample, 2005-2014, in elderly (65+ years) and non-elderly adult patients (18-64 years) with hemorrhoids who underwent emergency admission. Multivariable logistic regression model with backward elimination was used to identify predictors of mortality.

Results

25 808 adult and 26 978 elderly patients were included. Female patients consisted of 42.5% and 59.3% in adult and elderly, respectively. 42 (.2%) adults died, of which 50% were female and 125 (.5%) elderly patients died, of which 60% were female. Mean (SD) age of the adult patients was 47.8 (11) years and in elderly patients was 78.7 (8) years. 82.2% and 85.7% had internal hemorrhoids in adult and elderly patients, respectively. 9326 (36.1%) adult and 7282 (27%) elderly patients underwent an operation. In the final multivariable logistic regression model for adult patients with operation, delayed operation and invasive diagnostic procedures increased the odds of mortality, whereas in elderly patients, delayed operation and frailty index were the risk factors of mortality. In both adults and elderly with no operation, increased hospital length of stay (HLOS) significantly increased the odds of mortality, and undergoing an invasive diagnostic procedure significantly decreased the odds of mortality.

Conclusion

In all operated patients, increased time to operation and undergoing an invasive diagnostic procedure were the risk factors for mortality. On the other hand, in non-operated emergency hemorrhoids patients, increased age and increased HLOS were the risk factors for mortality while undergoing an invasive diagnostic procedure decreased the odds of mortality.
Prehospital Tourniquet Use Should be a Trauma Team Activation Criterion.
Authors: Coleman Kennith , Grabo Daniel , Wilson Alison , Bardes James
Published: January 2022

Purpose

Prehospital tourniquet application is not a standard trauma team activation (TTA) criterion recommended by the ACS COT. Tourniquet use has seen a resurgence recently with associated risks and benefits of more liberal usage. Our institution added tourniquet application as TTA criterion in January 2019. This study aimed to evaluate the effect this would have on patient care and overtriage.

Methods

A prospective analysis was conducted for all TTA associated with tourniquets placed during 2019. An overtriage analysis was conducted utilizing a modified Cribari method as described in Resources for the Optimal Care of the Injured Patient, comparing patients that met standard TTA criteria (TTA-S), to those who met criteria due to tourniquet placement (TTA-T).

Results

During the study, there were 46 TTA with tourniquets. Mean prehospital tourniquet time was 80 minutes. Median ISS was 10, 8 (17%) had an ISS >15. Urgent operative intervention was needed in 74%, with 23% and 21% requiring orthopedic and vascular procedures, respectively. Tourniquets were correctly placed in 80% and clinically appropriate in 57%. Of these subjects, 25 (54%) were TTA-S and 21 TTA-T. Overtriage analysis was performed. Overtriage for TTA-T was 33.3%. Overtriage among TTA-S was 4%.

Conclusion

Patients with prehospital tourniquets are frequently severely injured. The immediate presence of a trauma surgeon can have significant impacts in these cases. This is particularly important in a rural environment with long tourniquet times. Prehospital tourniquet application as a TTA criteria does not result in excessive overtriage.
Surgical Stabilization of Rib Fractures Improves Outcomes in the Geriatric Patient Population
Authors: Christie Dudley B. , Nowack Timothy E. , Nonnemacher Cory J. , Montgomery Anne , Ashley Dennis W.
Published: January 2022

Introduction

Rib fractures in the ≥65-year-old population have been shown to strongly influence mortality and pneumonia rates. There is a growing body of evidence demonstrating improvements in the geriatric patient’s survival statistics and respiratory performances after surgical stabilization of rib fractures (SSRF). We have observed a strong survival and complication avoidance trend in geriatric patients who undergo SSRF. The purpose of our study was to evaluate the outcomes of geriatric patients with rib fractures treated with SSRF compared to those who only receive conservative therapies.

Methods

We performed a retrospective review of our trauma registry analyzing outcomes of patients ≥65 years with rib fractures. Patients admitted from 2015 to 2019 receiving SSRF (RP group) were compared to a nonoperative controls (NO group) admitted during the same time. Bilateral fractures were excluded. Independent variables analyzed = ISS, mortalities, hospital days, ICU days, pleural space complications, and readmissions. Follow-up was 60 days after discharge. Group comparison was performed using Kolmogorov-Smirnov, Shapiro-Wilk, and Mann-Whitney U tests.

Results

257 patients were analyzed: 172 in the NO group with mean age of 75 (65-10) and 85 in the RP group with mean age of 74 (65-96). Mean ISS = 13 (1-38) for the NO group and 20 (9-59) for the RP group ( P < .001). Mean hospital days = 8 (1-39) and 15 (3-49) in NO and RP groups, respectively. Mean ICU days = 10 (1-32) and 8 (1-11) in NO and RP groups, respectively. Deaths, pneumonia, readmissions, and pleural effusions in the NO group were statistically significant ( P < .01). Analysis of complications revealed 4 RP patients (4.7%) with respiratory complications out to 60 days and 65 NO patients (37.8%) ( P < .001).

Conclusions

Surgical stabilization of rib fractures appears to be associated with a survival advantage and an avoidance of respiratory-related complications in the ≥65-year-old patient population.
Transumbilical Repair for Umbilical Hernia: A New Technique
Authors: Ohba Go , Yamamoto Hiroshi , Minato Masashi , Nakayama Masato , Honda Shohei , Taketomi Akinobu
Published: January 2022

Although there are many reports on surgical repair for umbilical hernia, there is no standard procedure at present. Since 2012, we have performed surgery with transumbilical repair using an original procedure. With this procedure, a longitudinal incision is made in the umbilicus, and the fascial defect is closed. Excess skin is excised at a fixed length. The fascia and dermis are sutured vertically over a length of 15 mm. A total of 424 patients with pediatric umbilical hernia who underwent this procedure between September 2012 and December 2020 were reviewed. The mean operative duration was 52 minutes. All patients were followed up to 6 months after surgery. Postoperative complications included infection in 15 patients and wound granulation in 5 patients. The morphology of the umbilicus is natural and satisfying. We conclude that this procedure is safe and simple and the results are satisfactory.
Experimental damage tolerance evaluation of thick fabric carbon/epoxy laminates under low-velocity and high-velocity impact and compression-after-impact
Authors: van Hoorn Niels , Kassapoglou Christos , Turteltaub Sergio , van den Brink Wouter
Published: January 2022

Impact experiments of thick fabric carbon/epoxy laminate specimens, with small thickness ratio, are conducted at distinct energy levels and thicknesses to characterise the damage process. These specimens and loading conditions are representative of a new generation of critical structural components in aviation, such as wing spars, landing gear beams and fittings, that are increasingly being made entirely from composites. The tests address the need to better understand the damage process for specimens with a small thickness ratio since existing experimental impact data for large thickness ratio (thin laminates) may not be directly applicable. Two energy levels, two different fabric layups and two impact methods (drop-weight and gas-cannon) were used. Data from high-speed cameras were processed in a novel way, providing the force during impact. C-scans and micrographs were used to characterise damage. The results show that specimens with a thickness ratio of 5 (20 mm thick) experience more bending compared to specimens with a ratio 2.5 (40 mm thick). For gas-cannon impacts, this results in a higher delaminated area. The drop-weight impacts show almost no differences in damage size for the thickness range analysed. The influence of layup on the global impact response is negligible, but locally it can result in significant variations in dent depth. The dent depth scales linearly with the impact energy and the delaminated area linearly with the impact velocity. There is no clear correlation between the compression-after-impact failure mechanisms and the residual strength. Impact damage, at the current energy levels, showed a minimal reduction of residual strength.
Fracture toughness and fractographic investigation of polybutylene terephthalate/thermoplastic polyurethane binary blends reinforced by multi-walled carbon nanotubes using essential work of fracture approach
Authors: Chalabi Tehran Ata , Heidari Farshad , Chakherlou Tajbakhsh Navid , Najjar Reza
Published: January 2022

In this paper, fracture toughness evaluation of polybutylene terephthalate (PBT)/thermoplastic polyurethane (TPU) binary blends and PBT/TPU/carbon nanotubes (CNTs) ternary nanocomposites have been conducted using both Izod impact and quasi-static fracture tests. Essential work of fracture (EWF) approach is used to study the fracture properties in details. The results of EWF tests revealed an effective role of TPU and CNTs in toughening mechanism of binary blends and ternary nanocomposites. According to EWF results, both the crack resistance and plastic deformation energies promoted in all compounds as compared to neat PBT. Energy dissipation in the yielding and tearing stages determined by the energy partitioning method. The obtained results indicated that displacement up to the failure point increased by increasing the TPU content, while inclusion of CNTs reduced this quantity. The specific non-essential work of fracture [Formula: see text] , [Formula: see text], and [Formula: see text] increased with increasing the TPU contents which is confirmed by load-displacement curves. Whereas, addition of CNTs reduced [Formula: see text] and [Formula: see text] values as compared to reference binary blend, however, ternary nanocomposites still have higher values as compared to pure PBT. In contrast with EWF results, high strain rate of impact test prevents the activation of toughness improving mechanisms that readily occurs in quasi-static loading.
Nano-hybridization effects of nano-silica and nano-graphene platelet on mechanical properties of E-glass/epoxy nanocomposites
Authors: Aydoğuş Osman , Demirci Mehmet Turan
Published: January 2022

This study reveals the nano-hybridization effects of nano-graphene platelets (NGPs) and nano-silica (SiO2 nanoparticle), having different structural geometries on the mechanical properties, nano and micro-scale failure behaviors, and nanoscale fracture mechanisms of E-glass/epoxy composites. Tensile, three-point bending, and Charpy impact experiments were applied to determine the mechanical behaviors of 0.5 wt.% NGPs, 4 wt.% nano-silica and 0.5 wt.% NGPs + 4 wt.% nano-silica nanohybrid filled E-glass/epoxy and neat E-glass/epoxy composite samples. Failure of composite samples was examined by microscopy and SEM analysis. FTIR analyses were conducted to interpret the chemical and physical interactions between the nanoparticles and epoxy resin. Nano-hybridization exhibited the highest tensile strength and three-point flexural force for the composite samples. However, the NGPs filled nanocomposites also exhibited the best static tensile toughness and impact energy absorption. The experimental data showed that it was statistically significant as a result of the one-way ANOVA analysis. Remarkably, nano-hybridization of nano-silica and NGPs showed different fracture mechanisms at the nano and micro-scales.
A precise method of color space conversion in the digital printing process based on PSO-DBN
Authors: Su Zebin , Yang Jinkai , Li Pengfei , Jing Junfeng , Zhang Huanhuan
Published: January 2022

Neural networks have been widely used in color space conversion in the digital printing process. The shallow neural network easily obtains the local optimal solution when establishing multi-dimensional nonlinear mapping. In this paper, an improved high-precision deep belief network (DBN) algorithm is proposed to achieve the color space conversion from CMYK to L*a*b*. First, the PANTONE TCX color card is used as sample data, in which the CMYK value of the color block is used as input and the L*a*b* value is used as output; then, the conversion model from CMYK to L*a*b* color space is established by using DBN. To obtain better weight and threshold, DBN is optimized by a particle swarm optimization algorithm. Experimental results show that the proposed method has the highest conversion accuracy compared with Back Propagation Neural Network, Generalized Regression Neural Network, and traditional DBN color space conversion methods. It can also adapt to the actual production demand of color management in digital printing.
“It’s More Us Helping Them Instead of Them Helping Us”: How Class Disadvantage Motivates Asian American College Students to Help Their Parents
Authors: Harrington Blair
Published: January 2022

While considerable attention has been given to the ways that parents contribute to undergraduates’ success, far less attention has been given to what these students do for their families, variation in students’ provision of help, or the consequences of giving. Drawing on 61 interviews with Asian American college students from diverse ethnic and class backgrounds, this paper extends conventional understanding of families and college by analyzing the financial assistance and translation support Asian American undergraduates give their parents. Using a trichotomous model of class—comparing disadvantaged, advantaged, and ambiguous students—I show that class disadvantage motivated students’ helping, advantage deterred it, while the ambiguous fell in between. Culture (i.e., filial piety) and a broad view of family (i.e., siblings’ contributions) also influenced students’ help. Finally, based on interview data combined with partial support from analysis of participants' grade point averages data, I demonstrate that helping had positive and negative implications for students’ college experience.
Does Gender Difference Exist in Typologies of Intergenerational Relations? Adult Son-Parent and Daughter-Parent Relations in Hong Kong
Authors: Peng Chenhong , Cheng Qijin , Yip Paul S. F.
Published: January 2022

This study examines the typologies of adult son–parent and daughter–parent relations in Hong Kong, a place where East meets West. The data were drawn from a survey of 834 adult children (381 sons and 453 daughters) aged between 18 and 59 with at least one living parent. Latent class analysis identified four types of relations for both son-parent and daughter-parent relations: tight-knit, distant ascending ties, obligatory, and detached. Sons were more likely to engage in obligatory and tight-knit relations with parents, whereas daughters were more likely to engage in distant ascending ties relations. Multinomial logistic regression found that adult children who were young, single, or co-residing with their child aged above 18 were more likely to have tight-knit relations with their elderly parents. Our findings suggest that although the male-dominated norm remains influential in Hong Kong, daughters are increasingly maintaining close interactions with their parents.
Homeless shelters and the blues
Authors: Siener Christian D
Published: January 2022

In this article, I analyze the emergence of New York City’s infrastructure of homeless shelters dialectically, relationally, and historically. The members of Boogie Down Productions met in an incipient New York City homeless shelter in the mid-1980s. Their relationship and music is a window into a critical political consciousness of men living in homeless shelters because the artists gave expression to an emergent structure of feeling of resistance taking hold during intense changes to New York’s political economy and its institutions. The paper first analyzes homeless policy and infrastructural change through a reading of archival sources and government reports and documents. The second section understands oral histories conducted with men living in a New York City homeless shelter as blues geographies—insurgent, critical explanations of these institutional spaces. Shelter residents actively challenge the material conditions, relations, and values that produce homeless shelters as essential instruments of the carceral state. I argue that they activate this resistance to the naturalization of shelters, and themselves as homeless, by narrating carceral spaces as abolitionist spaces.
An inherited night blindness in Wiltshire sheep
Authors: Hunt Hayley , Dittmer Keren E. , Garrick Dorian J. , Fairley Robert A. , Heap Stephen J. , Jolly Robert D.
Published: January 2022

Twelve cases of adult-onset blindness were identified in a flock of 130 polled Wiltshire sheep in New Zealand over a 3-year period. Affected sheep developed night blindness between 2 and 3 years of age, which progressed to complete blindness by 4 to 5 years of age. Fundic examination findings included progressive tapetal hyperreflectivity and attenuation of retinal blood vessels. Histologically, the retinas had a selective loss of rod photoreceptors with initial preservation of cone photoreceptors. Retinal degeneration was not accompanied by any other ocular or central nervous system abnormalities, and pedigree analysis suggested an inherited basis for the disease. Mating an affected Wiltshire ram to 2 affected Wiltshire ewes resulted in 6 progeny that all developed retinal degeneration by 2 years of age, while mating of the same affected ram to 6 unaffected ewes resulted in 8 unaffected progeny, consistent with autosomal recessive inheritance. Homozygosity mapping of 5 affected Wiltshire sheep and 1 unaffected Wiltshire sheep using an OvineSNP50 Genotyping BeadChip revealed an identical-by-descent region on chromosome 5, but none of the genes within this region were considered plausible candidate genes. Whole-genome sequencing of 2 affected sheep did not reveal any significant mutations in any of the genes associated with retinitis pigmentosa in humans or progressive retinal atrophy in dogs. Inherited progressive retinal degeneration affecting rod photoreceptors has not been previously reported in sheep, but this disease has several similarities to inherited retinal dystrophies in other species.
I’m Only Human: A New E-road to Advancing Social Equity Through a Humanist Approach to Mentoring in Public Service
Authors: Neal Sue M. , Kline Angela , Olejarski Amanda M. , Gherardi Michelle
Published: January 2022

This research reviews how mentoring has manifested in public service and how it can evolve to be better positioned to address key diversity, equity, and inclusion objectives. This work inventories the current understanding of public sector mentoring, highlighting the contrast between the classical mentoring approach of functionalism with the emerging humanist approach. Barriers to implementing meaningful humanist mentoring are reviewed, and e-mentoring is presented as a modality well situated to overcome these obstacles. The humanist e-mentoring model provides a process and modality to advance social equity by removing existing barriers to opportunities. Finally, best practices and outcomes for successfully implementing e-mentoring humanist and relationships in public service are presented and an updated model of critical outcomes is advanced. A brief agenda for future scholarship on this topic is presented.
Managerial Challenges of Emotional Labor Disruption: The COVID-19 Crisis in Mexico
Authors: Varela Castro Samanta , Pérez-Chiqués Elizabeth , Meza Oliver , Campos González Sergio A.
Published: January 2022

The purpose of this article is to contribute to the knowledge of managing emotional labor during a crisis. The COVID-19 pandemic has been a disrupting event, particularly affecting frontline healthcare workers and their supervisors who faced pressures to manage emotions during their interactions with patients. Emotional labor has been studied in emergencies; however, the case of Mexico offers insights into an understudied context and a long and singular crisis. Drawing from multi-level storytelling interviews with medical managers, physicians, and nurses in hospitals in different states of Mexico, this article argues that COVID-19 blurred relationships between performance and outcomes of emotional labor. As the organizational goal focused mainly on saving lives, some workers intensified and performed emotional labor innovatively, but others deviated from feeling rules. Managers’ role became crucial for employees to abide by affective requirements facing disruption.
Educational Differences in Self-Rated Health Trends Among Middle-Aged and Older Adults Living Alone, 1972–2018
Authors: Lamidi Esther O.
Published: January 2022

Objectives: This study examines educational differences in living alone and in self-rated health trends among middle-aged and older adults. Methods: We used logistic regression to analyze data from the 1972–2018 National Health Interview Survey ( n = 795,239 aged 40–64; n = 357,974 aged 65–84). Results: Between 1972–1974 and 2015–2018, living alone became more prevalent, particularly among men and at lower levels of education. Self-rated health trends varied by living arrangement and education. We found self-rated health declines among middle-aged adults having no college degree and living alone, but trends in self-rated health were mostly stable or even improved among middle-aged adults living with others. Among older adults, self-rated health improved over time, but for the least-educated older Americans living alone, the probability of reporting fair or poor health increased between 1972–1974 and 2015–2018. Discussion: The findings suggest growing disparities by social class, in living arrangements and in self-rated health.
Seroprevalence of herpes simplex virus types 1 and 2 and correlates of infection in Jordan
Authors: Swedan Samer F , Darabseh Alia’
Published: January 2022

Background

Herpes infections are common infections among populations. Herein, a cross-sectional study was used to determine the seroprevalence of herpes simplex virus type 1 (HSV-1) and herpes simplex virus type 2 (HSV-2) IgG antibodies and their association with potential infection risk factors among Jordanians.

Methods

A total of 759 serum samples were collected (January to February 2020) and analyzed for HSV-1 and HSV-2 IgG antibodies by enzyme-linked immunosorbent assay. Estimates for population seropositivity were determined by weighting the age-specific seroprevalence by the size of the population in each age stratum.

Results

The population estimate for HSV-1 seroprevalence was 75.3%. After adjustment for possible confounders, regression analysis revealed higher seroprevalence with increase in age ( p < 0.005) and low household income ( p = 0.002). The population estimate for HSV-2 seroprevalence was 2.9%. No significant differences in HSV-2 seroprevalence were observed in association with age, gender, family size, educational level, and socioeconomic status, likely due to low seropositivity.

Conclusions

Jordanians have high HSV-1 and low HSV-2 seroprevalence. Periodical studies might be needed to evaluate changes in HSV-1 and HSV-2 seroprevalence over time. This study provides essential epidemiological data for Jordan and the Middle East and North Africa region.
Corpus stylistics and colour symbolism in The Great Gatsby and its Thai translations
Authors: Wijitsopon Raksangob
Published: January 2022

The present study adopts a corpus stylistic approach to: (1) examine a relationship between textual patterns of colour words in The Great Gatsby and their symbolic interpretations and (2) investigate the ways those patterns are handled in Thai translations. Distribution and co-occurrence patterns were analysed for colour words that are key in the novel: white, grey, yellow and lavender. The density and frequent patterns of each word are argued to foreground an association between the colour word and particular concepts, pointing to symbolic meaning potentials related to the novel’s themes of socioeconomic inequality and destructive wealth. The textual patterns are compared with what occurs in three Thai translations of the novel. While most of the colour images are directly translated, non-equivalents tend to be applied to figurative uses of the colour terms. This results in some changes in textual patterns of the colour words in the translated texts, which can in turn affect readers’ interpretations of colour symbolism in the novel.
I can see Clearly Now: Developing a Camera-Based Automotive Rear-View Mirror Using a Human-Centred Philosophy
Authors: Malcolm Louise , Herriotts Paul
Published: January 2022

Driving is a visual task and as such it is essential that drivers have good vision out of their vehicles particularly on today’s busy roads. However, rear vision is not always optimum; rear passengers, luggage or the design of the car itself can all impair rear vision. A new camera-based rear view mirror is described in this paper. The system was developed by employing user-centred design methods; requirements for the system were established and a prototype was then tested dynamically with drivers’ feedback then used to improve and finalise the design.
‘It’s possibly made us feel a little more alienated’: How people from ethnic minority communities conceptualise COVID-19 and its influence on engagement with testing
Authors: Vandrevala Tushna , Alidu Lailah , Hendy Jane , Shafi Shuja , Ala Aftab
Published: January 2022

Objectives

The cultural beliefs, practices and experiences of ethnic minority groups, alongside structural inequalities and the political economy play a critical, but overlooked role in health promotion. This study aimed to understand how ethnic minority groups in the United Kingdom conceptualised COVID-19 and how this influenced engagement in testing.

Method

Black (African and Caribbean) and South Asian (Indian, Pakistani and Bangladeshi) community members were purposefully recruited from across the UK. Fifty-seven semi-structured interviews were conducted and analysed using principles of grounded theory.

Results

We found that people of Black and South Asian ethnicity conceptualised COVID-19 as a disease that makes them visible to others outside their community and was seen as having more severe risk and suffering worse consequences, resulting in fear, stigmatisation and alienation. Views about COVID-19 were embedded in cultural beliefs, relating to culturally specific ideas around disease, such as ill-health being God’s will. Challenges brought about by the pandemic were conceptualised as one of many struggles, with the saliency of the virus contextualised against life experiences. These themes and others influenced engagement with COVID-19 testing. Testing was less about accessing timely and effective treatment for themselves and more about acting to protect the family and community. Testing symbolised a loss of income, anxiety and isolation, accentuated by issues of mistrust of the system and not being valued, or being treated unfairly.

Conclusion

Health communications should focus on counterbalancing the mistrust, alienation and stigmatisation that act as barriers to testing, with trust built using local credible sources.
The intergenerational transmission of maternal adverse childhood experiences on offspring’s psychiatric disorder and the mediating role of maternal depression: Results from a cross sectional study
Authors: Kang Na Ri , Kwack Young Sook , Song Jung-Kook , Kim Moon-Doo , Park Joon Hyuk , Kim Bung-Nyun , Moon Duk-Soo
Published: January 2022

Maternal adverse childhood experiences (ACEs) may negatively affect the mental health and development of their offspring. The purpose of this study was to investigate the association of maternal ACE and offspring’s psychiatric disorder and the mediating effect of maternal depression. The subjects included 463 mothers (42.78 ± 5.68 years) and their offspring aged 6–18 years (13.26 ± 3.90 years). Mothers reported their ACE before age 18 and completed the Beck Depression Inventory-II and Diagnostic Predictive Scales (DPS), a screening tool for offspring’s psychiatric disorder. 35.42% of subjects had at least one ACE, and 11.0% reported three or more ACEs. Higher maternal ACE scores were associated with a significantly higher prevalence of offspring’s psychiatric disorders ( p < 0.001). Household dysfunction of maternal ACE (OR = 2.263, p < 0.001) is significantly associated with offspring’s psychiatric disorder. In the mediation model in which the household dysfunction affects the number of offspring’s psychiatric disorders, the partial mediation model through maternal depression was significant. The mother’s experience of household dysfunction before the age of 18 has a significant impact on her offspring’s psychiatric disorder and supported significant mediation through maternal depression. Further research is needed to determine the mechanisms of intergenerational transmission of ACE and offspring’s psychopathology.
A ‘Proper Night Out’: A Practice Theory Exploration of Gendered Drinking
Authors: Hennell Kath , Limmer Mark , Piacentini Maria
Published: January 2022

Drawing on the three-element model of social practice theory and key conceptualisations relating to gender performance, this article reports on an empirical study of the intersecting practices of drinking alcohol and doing gender. We present data from a 14-month research project to explore the online and offline intoxicated drinking practices of 23 young people in England framed as a ‘proper night out’. The data were analysed with a focus on three elements (the ‘corporeal’, ‘alcohol’, and ‘caring’), and the findings demonstrate how young people collectively practice gender through their intoxicated drinking practices. This operationalisation of practice theory highlights the potential value that a practice theory lens has for exploring gendered social practices and broadening understandings of notions of acceptable and suitable practice performance.
Deformation analysis of axially loaded weak PVC-fiber reinforced polymer confined concrete column-strong reinforced concrete beam joints reinforced with core steel tube
Authors: Yu Feng , Zou Qiye , Fang Yuan , Li Dongang , Bu Shuangshuang
Published: January 2022

This paper presents an experimental study on 11 weak PVC-FRP Confined Concrete (PFCC) Column-strong Reinforced Concrete beam joints reinforced with Core Steel Tube (CST) subjected to axial load. The influences of the joint height, joint stirrup ratio, Carbon Fiber Reinforced Polymer (CFRP) strips spacing, steel ratio and CST length on the failure mode, ultimate strength, and strain behavior of specimens are analyzed and discussed. Test results indicate that the failure mode of specimens is distinguished by the cracking of PVC tube, fracture of CFRP strips, yielding of stirrups, and longitudinal steel bars in the PFCC columns. Both the longitudinal steel bars and CST yield at the joint area, while there is no obvious damage on the joint. The ultimate stress of specimens decreases with the increment of CFRP strips spacing, while the other studied variables have little impact on the ultimate stress. As the CFRP strips spacing increases, the ultimate strain of specimens decreases, and the strain development accelerates. Considering the effect of joint dimension, a modified prediction model for the stress–strain relationship of axially loaded weak PFCC column-strong RC beam joints reinforced with CST is proposed and verified with good accuracy.
Bond parameters for peeling and debonding in thin plated RC beams subjected to mixed mode loading – Framework
Authors: Khan Mohammad Arsalan
Published: January 2022

Studies have primarily focussed on predicting mode-II debonding failure; whereas, in real-case-scenario, flexurally strengthened reinforced concrete (RC) beams observe premature failure mechanisms under mixed-mode loading conditions engaging geometrical and material variations. Peeling is a consequence of flexural crack as debonding is of interfacial shear crack. Under bending, peeling failure is considerably catastrophic over debonding due to the nature of crack formation; therefore, this needs to be distinguished in predictive analysis. In this paper, a new numerical modeling methodology is approached using eXtended finite element method (xFEM) for flexural cracks and Cohesive Zone Model (CZM) for shear cracks without predefining crack locations. The parameters of the constitutive models are identified through comparing finite element results with the experimental data. These parameters are related to key material properties. Based on proposed framework, the models provide a good estimation of plate strain distribution, cracks and failure type, in terms of mode and load of failure. Bilinear bond-slip curve is a closer match over exponential crack evolution at interface.
Black maternal mortality in the media: How journalists cover a deadly racial disparity
Authors: Walker Denetra , Boling Kelli
Published: January 2022

Through semi-structured interviews with four women news journalists, this study explores how journalists who specialize in women’s issues and health cover Black maternal mortality. Discussions include the role of advocacy in journalism and the struggle of covering the complex, long-standing systemic issue of maternal mortality associated with race in American society. Six themes consider the inclusion of race in healthcare coverage, a need for in-depth, nuanced coverage, the role of advocacy in journalism, complications of reporting on race, the importance of citing sources of color, and celebrity influence. Findings show the need for media advocacy in public health crises, and how journalistic norms can pressure journalists into citing inappropriate sources or diluting the story.