bluuebunny/crossref_metadata_2025 huggingface dataset:
Dynamic Analysis Method of Liquid-Filled Containers considering the Fluid-Structure Interaction Effect
Authors: Fang Xi bing , Bao Xin , Yue Fengjiang , Zhao Qiyuan
Published: January 2024

Based on acoustic fluid elements, dynamic analysis was performed on liquid sloshing modes and liquid-filled containers considering the fluid-structure interaction (FSI) effect. The liquid sloshing modes in two-dimensional (2D) and three-dimensional (3D) containers were analyzed, and the results were compared with liquid sloshing modes measured in tests and theoretically calculated modes. This thus verifies correctness of the simulation method based on acoustic fluid elements. Cylindrical liquid-filled containers with different water levels were subjected to modal analysis and dynamic and time-historical analysis. Results show that the finite element analysis (FEA) based on acoustic fluid elements can accurately simulate liquid sloshing modes in liquid-filled containers and vibration characteristics of these containers with different liquid levels. The vibration frequency of liquid-filled containers declines obviously with rising liquid level. The liquid level significantly affects distributions of the maximum displacement, maximum acceleration, and maximum von Mises stress on the sidewall of liquid-filled containers. Numerical simulations based on acoustic fluid elements provides an effective and reliable method for dynamic analysis of liquid-filled containers considering the FSI effect.
Tourism Policy Development and Change: An Examination of Sustainability in India’s Tourism Policy 2022 and its Implications.
Authors: Pathak Anant Kumar
Published: January 2024

The article discusses how tourism policy has changed since World War II, highlighting how the everchanging political and economic climate has shaped policies that were formerly centered on promoting inbound travel and tourist growth to becoming more inclusive and sustainable. Within that framework, the paper systematically examines the development of Indian tourism policy and thoroughly explores the implications of its most recent version. It concludes that modern tourism policies have evolved into comprehensive frameworks that structure the growth of the industry and make it more inclusive and sustainable. Nations such as India are well-suited to meet the demands of modern tourism and offer appropriate frameworks for sustainable and resilient tourist growth.
Numerical Model of Simultaneous Multi-Regime Boiling Quenching of Metals
Authors: González-Melo Marco Antonio , Rodríguez-Rodríguez Omar Alonso , Hernández-Morales Bernardo , Acosta-González Francisco Andrés
Published: January 2024

This work presents a heat transfer and boiling model that computes the evolution of the temperature field in a representative steel workpiece quenched from 850 or 930°C by immersion in water flowing at average velocities of 0.2 or 0.6 m/s, respectively. Under these conditions, all three boiling regimes were present during cooling: stable vapor film, nucleate boiling, and single-phase convection. The model was based on the numerical solution of the heat conduction equation coupled to the solution of the energy and momentum equations for water. The mixture phase approach was adopted using the Lee model to compute the rates of water evaporation-condensation. Heat flux at the wall was calculated for all regimes using a single semi-mechanistic model. Therefore, evolution of boiling regimes at every position on the wall surface was automatically determined. Predictions were validated using laboratory results, namely: a) Videorecording the upward motion of the wetting front along the workpiece wall surface, and b) cooling curves obtained with embedded thermocouples in the steel probe. Wall heat flux calculations were used to determine the importance of the simultaneous presence of all three boiling regimes on the heat flux distribution. It was found that this simultaneous presence leads to high heat flux variations that should be avoided in production lines.
An Artificial Intelligence (AI) Framework To Predict Operational Excellence: UAE Case Study
Authors: Hassan Rola R. , Abu Talib Manar , Dweiri Fikri , Roman Jorge
Published: January 2024

The integration of artificial intelligence (AI) into the European Foundation for Quality Management (EFQM) business excellence model is a promising approach to improve the efficiency and effectiveness of excellence in organizations. This research paper’s integrated framework follows the ISO/IEC 23053 standard in addressing some of the concerns related to time and cost associated with the EFQM model, achieving higher EFQM scores, hence operational excellence. A case study involving a UAE government organization serves as a sample to train the AI framework. Historical EFQM results from different years are used as training data. The AI framework utilizes the unsupervised machine learning technique known as k-means clustering (with k=2). This technique follows the ISO/IEC 23053 standard to predict EFQM output total scores based on criteria and sub-criteria inputs. The research paper's main output is a novel AI framework that can predict EFQM scores for organizations at an early stage. If the predicted EFQM score is not high enough, then the AI framework provides feedback to decision makers regarding the criteria that need reconsideration. Continuous use of this integrated framework helps organizations attain operational excellence. This framework is considered valuable for decision makers as it provides early predictions of EFQM total scores and identifies areas that require improvement before officially applying for the EFQM excellence award. This approach can be considered as an innovative contribution and enhancement to knowledge body and organizational practices.
ML-Based Detection of DDoS Attacks Using Evolutionary Algo-Rithms Optimization
Authors: Talpur Fauzia , Korejo Imtiaz Ali , Chandio Aftab Ahmed , Ghulam Ali , Talpur Sajjad Hussain
Published: January 2024

The escalating reliance of modern society on information and communication technology has rendered it vulnerable to an array of cyber-attacks, with distributed denial-of-service (DDoS) at-tacks emerging as one of the most prevalent threats. This paper delves into the intricacies of DDoS attacks, which exploit compromised machines numbering in the thousands or more to disrupt data services and online commercial platforms, resulting in significant downtime and financial losses. Recognizing the gravity of this issue, various detection techniques have been explored, yet the quantitative and prior detection of DDoS attacks has seen a decline in recent methods. This research introduces an innovative approach by integrating evolutionary optimization algorithms and machine learning techniques. Specifically, the study proposes XGB-GA Optimization, RF-GA Optimization, and SVM-GA Optimization methods, employing Evolutionary Algorithms Opti-mization with TOPOT-Genetic Programming. Datasets pertaining to DDoS attacks were utilized to train machine learning models based on XGB, RF, and SVM algorithms, and 10-fold cross-validation was employed. The models were further optimized using evolutionary algo-rithms, achieving remarkable accuracy scores: 99.99% with the XGB-GA method, 99.50% with RF-GA, and 99.99% with SVM-GA. Furthermore, the study employed TPOT to identify the optimal algorithm for constructing a machine learning model, with the genetic algorithm pinpointing XGB-GA as the most effective choice. This research significantly advances the field of DDoS attack detection by presenting a robust and accurate methodology, thereby enhancing the cybersecurity landscape and fortifying digital infrastructures against these pervasive threats.
Economic Impact of Lean Healthcare Implantation on the Surgical Process
Authors: Sales Coll Marc , De Castro Rodolfo , Ochoa de Echagüen Anna , Martinez Ibáñez Vicenç
Published: January 2024

Objectives: To analyse and detail surgical process improvement activities that achieve the highest economic impact.
Methods: Over 4 years, a team of technicians and healthcare professionals implemented a set of Lean surgical process improvement projects at Vall d’Hebron University Hospital (VHUH), Barcelona, Spain. These projects now form part of the daily routine in the surgical process. The economic impact on the hospital's surgical activity budget was analysed.
Results: Process improvements have led to annual operational savings of over € 8.5 million. These improvements include better patient flow, better management of information between healthcare professionals, and improved logistic circuits.
Conclusions: The current cultural shift towards process management in large hospitals implies shifting towards results-based healthcare, patient-perceived value (VBHC) and value-added payment. A Lean project implementation process requires long-term stability. The reason a considerable number of projects fail to complete process improvement projects is the difficulty involved in establishing the project and improving management routines. Few studies in the literature have investigated the economic impact of implementing Lean management a posteriori, and even fewer have examined actual cases. In this real case study, changes to surgical block management were initiated from zero. After being carefully thought through and designed, changes were carried out and subsequently analysed.
Assembly Theory of Binary Messages (How to Assemble a Black Hole and Use it to Assemble New Binary Information?)
Authors: Łukaszyk Szymon , Bieniawski Wawrzyniec
Published: January 2024

Using assembly theory, we investigate assembly pathways of fixed-length binary strings formed by joining the individual bits present in the assembly pool and the strings that entered the pool as a result of previous joining operations. We show that the string assembly index is bounded from below and above. We derive the lower bound and conjecture the upper bound's form. We conjecture that a black hole surface is defined by a balanced distinct string that satisfies the upper bound of a distinct string assembly index. The results confirm that four Planck areas provide the minimum information capacity that provides a minimum thermodynamic (Bekenstein-Hawking) entropy. Knowing that the problem of determining the assembly index is at least NP-complete, we conjecture that the problem of determining the assembly index of a given binary string is NP-complete, while the problem of creating the string so that it would have a predetermined maximum assembly index is NP-hard. Therefore, once the new information is assembled by a dissipative structure or by a human, increasing the information entropy according to the second law of infodynamics, it is subject to the second law of thermodynamics, and nature seeks to optimize its assembly pathway.
Aggressive course of atherosclerosis in hyperlipoproteinemia (a): a case series
Authors: Namitokov A. M. , Zaphiraki V. K, , Donets E. K. , Malyarevskaya O. B. , Karabakhtsieva K. V. , Yahutl A. N.
Published: January 2024

Currently, worldwide interest in lipoprotein(a) (LP(a) as one of the most important markers of premature and aggressive atherosclerosis is steadily growing. This trend is due to both the new data on the pathogenesis of hyperlipoproteinemia (a) and the development of novel treatment methods in the near future. The variety of clinical manifestations of atherosclerosis associated with high LP(a) concentrations leads such patients to specialists of various profiles. The aim of this paper was to demonstrate, using examples from the practice of two lipid centers in Krasnodar, the diversity of clinical scenarios of atherosclerosis as a systemic disease in patients with very high LP(a) levels, as well as to highlight the current and future options for the treatment of hyperlipoproteinemia (a).
Place of imidazoline receptor agonists in the treatment of arterial hypertension
Authors: Nebieridze D. V. , Safaryan A. S. , Ivanova E. I. , Poddubskaya E. A.
Published: January 2024

The review is devoted to one of the most controversial issues of modern antihypertensive therapy — the role of new generation sympatholytics — selective I1-imidazoline receptor agonists (AIRs). In modern European recommendations, AIR (moxonidine rilmenidine), along with other centrally acting drugs (reserpine, alpha-methyldopa, clonidine), are mainly intended for additional therapy in rare cases of resistant hypertension, when other treatment options have been ineffective. Nevertheless, AIR invariably finds its place in Russian recommendations for the treatment of arterial hypertension (AH). This class of drugs is recommended for patients with AH in combination with metabolic syndrome and obesity. It is noted that an important property of AIR is its positive effect on carbohydrate and lipid metabolism. This information is based on an analysis of Russian and foreign studies, which convincingly indicate that this class of drugs not only provides adequate and long-term blood pressure control, but also has the above-mentioned positive metabolic effects. At the same time, AIRs are much less likely to cause side effects characteristic of older generation centrally acting drugs. Thus, AIRs have become firmly established in clinical practice in Russia for the treatment of patients with AH in certain clinical situations.
Pericarditis as an onset of cancer
Authors: Mesitskaya D. F. , Panov S. A. , Andreev D. A. , Volovchenko A. N. , Dumikyan A. Sh.
Published: January 2024

Pericarditis is an inflammation of the heart serous membrane of an infectious or non-infectious nature. Secondary pericardial effusion can be one of the few signs of cancer of the lung, pleura or breast in young people, while early treatment of the underlying pericarditis cause is the only factor influencing patient survival. We present a case report on a 28-year-old female patient who was hospitalized at the Sechenov University Cardiology Clinic for continuous recurrent pericarditis. During the examinations, end-stage lung adenocarcinoma was revealed, which for a long time was disguised as various diseases. Unfortunately, immunochemotherapy was not successful and the patient’s condition was complicated by recurrent pulmonary embolism with progressive cardiopulmonary failure. A peculiarity of this case is the development of recurrent pericarditis in a young female patient with lung adenocarcinoma, which is difficult to diagnose using non-invasive examination methods. Long-term ineffective treatment of recurrent pericarditis is a reason for cancer suspicion in young patients.
New possibilities for lipid level control using inclisiran — prospects for interaction between a cardiologist and a neurologist
Authors: Skiba A. B. , Menzorov M. V. , Puchek V. D. , Buchin I. M. , Polyakov I. I. , Menzorova E. N.
Published: January 2024

Dyslipidemia is one of the most significant modifiable cardiovascular risk factors. The change in the modern paradigm for dyslipidemia treatment from high-intensity statin therapy to high-intensity lipid-lowering therapy makes it possible to more often use new drug classes to achieve the target level of low-density lipoprotein cholesterol. The article presents two case reports on the use of inclisiran as part of combination lipid-lowering therapy for secondary prevention in patients at very high cardiovascular risk. Based on the presented cases, following clinical aspects of the management of cardiovascular patients are discussed: the safety of achieving low-density lipoprotein cholesterol levels below 1 mmol/l in a patient with asymptomatic cerebral infarction, the need for adequate dyslipidemia treatment after revascularization, the strategic importance of prescribing lipid-lowering therapy in patients with cerebrovascular disease to reduce the cardiovascular risk, adherence to therapy as a significant aspect of effective dyslipidemia control.
Acute kidney injury as a risk factor for atrial fibrillation after coronary artery bypass grafting — effects of sodium-glucose cotransporter-2 inhibitors
Authors: Kremneva L. V. , Arutyunyan L. A. , Gapon L. I. , Suplotov S. N. , Shalaev S. V.
Published: January 2024

Aim. To identify predictors of paroxysmal atrial fibrillation (pAF) in patients with stable angina after coronary artery bypass grafting (CABG), as well as to evaluate the effect of sodium-glucose cotransporter 2 (SGLT-2) inhibitors.

Material and methods. We examined 92 patients with stable angina who received CABG, aged 64±7 years (men, 78,3%). Among this cohort, 81,5% of patients had multivessel coronary artery disease, carbohydrate metabolism disorders — 35,6%, hypertension — 96,7%, chronic kidney disease (CKD) — 23,9%, preprocedural pAF — 10,9%, previous myocardial infarction (MI) — 54,3%. Off-pump CABG was performed in 31,5%, including bilateral inthernal thoracic artery grafting — in 50%. Cardiopulmonary bypass time was 68 (55-83) minutes. The number of grafts was 2,7±0,7. In addition, 18,5% of individuals received SGLT-2 inhibitors. Serum creatinine content was determined by the Jaffe method, and CKD was diagnosed with glomerular filtration rate <60 ml/min. Acute kidney injury (AKI) was assessed according to the KDIGO criteria (2012).

Results. The number of patients who had pAF after CABG was 29,3%, AKI — 16,3%. There were following parameters associated with pAF after CABG: creatinine (100;82-142 in patients with pAF and 83;69-105 μmol/l — without pAF, p=0,032) and urea (7,8;5,8-9,7 in patients with pAF and 5,9;4,7-9,1 mmol/l — without pAF, p=0,025) one day after the intervention; postoperative AKI was revealed in 33,3% and 9,2% (p=0,004), while the number of patients taking SGLT-2 inhibitors was 3,7% and 24,6% (p=0,019) in those with and without pAF, respectively. The probability of pAF after CABG increased by an average of 5,5 times with AKI. Patients with pAF after CABG compared to patients without pAF have a higher rate of AKI, intraoperative MI, and cardiac death.

Conclusion. The number of patients with pAF after CABG was 29,3%, AKI — 16,3%. Post-CABG pAF predictor was postoperative AKI. The use of SGLT-2 inhibitors was associated with a lower incidence of pAF after intervention. Patients with pAF after CABG have a poor inhospital prognosis.
Beta-blockers in chronic heart failure with preserved left ventricular ejection fraction: is deprescribing possible?
Authors: Zakiev V. D. , Vorobyeva N. M. , Malaya I. P. , Gvozdeva A. D. , Tkacheva O. N.
Published: January 2024

Chronic heart failure (CHF) is a complex clinical syndrome characterized by poor prognosis. According to the Russian epidemiological study EPOHA-CHF, more than half of patients with CHF have preserved left ventricular ejection fraction (LV EF). However, no class of drugs has proven effectiveness in improving the prognosis of this disease. Although current clinical guidelines do not recommend the routine use of beta-blockers in CHF patients with preserved LV EF in the absence of other indications for them, many patients with CHF with preserved LV EF take these drugs unreasonably. The review presents the data from studies on the efficacy and safety of betablockers in CHF with preserved LV EF and it withdrawal. Most studies included patient with LV EF >40%, a few of them analyzed only patients with LVEF ≥50%. Some studies of real clinical practice and meta-analysis of such studies demonstrated a positive effect of beta blockers in patients with LV EF > 40%, however randomized clinical trials and their meta-analyses revealed either a slight beneficial effect of beta-blockers. Studies involving only patients with LV EF ≥50% didn’t show the beneficial effects of beta blockers. There is only one trial accessing the withdrawal of beta blockers in patients with CHF with preserved LV EF and chronotropic insufficiency. The study showed a positive effect of deprescribing on exercise tolerance and quality of life. Due to controversial data, well-designed trials to examine the effect of beta-blockers on symptoms and prognosis in patients with CHF with LVEF ≥50% are required. Deprescribing of beta-blockers also require further assessment.
Endovenous laser ablation of great saphenous vein and pharmacotherapy of acute ascending thrombophlebitis: results of a three-month follow-up
Authors: Kaperiz K. A. , Rastatueva A. O. , Yavelov I. S. , Drapkina O. M.
Published: January 2024

Aim. In patients with acute ascending thrombophlebitis of the great saphenous vein and/or its large tributaries, assess the incidence of venous thrombosis progression over 3 months with 1,5-month fondaparinux sodium therapy and endovenous laser ablation of the saphenofemoral junction in combination with short-term (7-day) anticoagulant therapy or without anticoagulation.

Material and methods. This single-center, prospective, randomized, open-label study included data from 91 patients with acute ascending thrombophlebitis of the great saphenous vein and/or its large tributaries, of which 30 were in the group of endovenous laser ablation without anticoagulation, 32 — in the group of endovenous laser ablation in combination with 7-day fondaparinux therapy, and 29 — in the 1,5-month fondaparinux therapy group. Venous thrombosis progression rate within 90±2 days was assessed. Compression ultrasonography of lower limb veins was performed on days 7±2, 45±2 and 90±2 after randomization, as well as in case of thrombosis progression suspicion.

Results. The mean age of patients was 49,4±14,2 years. There were more women (73,6%). There was a low prevalence of risk factors for the development and progression of venous thrombosis: obesity — 6,6%, type 2 diabetes — in 2 patients, class 2 heart failure — in 1, autoimmune disease (scleroderma in remission) — in 1, prior cancer — in 1. Previous episodes of thrombophlebitis were noted in 3 cases (3,3%). Following external factors provoking venous thrombosis were identified in 19 patients (20,9%): lower leg injury in 14, high physical activity in 3, long flight in 1, recent coronavirus disease 2019 in 1. Median duration of thrombophlebitis manifestations was 6 days. Thrombosis was located in the trunk of the great saphenous vein in 96,7% of patients, while large tributaries were involved in 29,7%. The median distance from the thrombus proximal part to the saphenofemoral junction was 42,5 cm. Over 90±2 days, there were no cases of involvement of the suprafascial segment of the perforating vein in thrombosis to the fascia level, spread of thrombosis to the deep veins, or pulmonary embolism. Subsequently, a new episode of superficial vein thrombosis was noted only in 2 patients from the pharmacotherapy group with a history of thrombophlebitis.

Conclusion. In patients with a low risk of venous thrombosis progression and predominantly distal location of acute ascending thrombophlebitis of the great saphenous vein and/or its large tributaries after endovenous laser ablation, progression of venous thrombosis is not expected over the next 3 months, despite an anticoagulation reduction to 7 days or its refusal.
Earnings Quality Determinants: Evidence from Transportation and Logistics Companies
Authors: Herdina Trizka Alyaa , Hadiwibowo Imam , Azis Mohammad Taufik
Published: January 2024

Companies with good earnings quality are companies that have stable and sustainable income. This research was conducted with the aim of testing whether there is an effect of Investment Opportunity Set, leverage, and liquidity on earnings quality. The objects used are transportation and logistics companies listed on the IDX for the 2018-2022 period as many as 31 companies. This research is a descriptive research with a quantitative approach. The sampling method used purposive sampling technique. There were 17 companies that met the sample criteria with 5 years of observation, so the total sample was 85 samples. The data used is secondary data sourced from the company's financial statements accessed through the website www.idx.co.id. The method applied is multiple linear regression analysis with the IBM SPSS Version 25 application. This research partially shows the results that Investment Opportunity Set and liquidity do not affect earnings quality, while leverage affects earnings quality. Taken together Investment Opportunity Set, leverage, and liquidity affect the quality of earnings.
Aplikasi Gojek Sebagai Media Peningkatan Interasi Intra dan Antar Masyarakat
Authors: Ramdhani Reviandy Azhar , Rojabi M. Nafis , Mubarok Moch. Chusni , Refah Difa Azman , Roihan Roihan
Published: January 2024

Abstrak
Artikel ini bertujuan untuk mengeksplorasi peran aplikasi Gojek sebagai media untuk meningkatkan interaksi intra- dan antar-komunitas. Studi ini menyelidiki manfaat dan dampak aplikasi Gojek terhadap interaksi sosial dan efeknya pada masyarakat secara keseluruhan. Artikel ini membahas bagaimana aplikasi Gojek mempromosikan interaksi sosial dan komunikasi positif di antara penggunanya. Metodologi penelitian meliputi tinjauan pustaka dari penelitian sebelumnya yang terkait dengan topik dan analisis data kualitatif dari respons survei dari pengguna Gojek. Temuan menunjukkan bahwa aplikasi Gojek memberikan kesempatan bagi orang untuk terhubung dan berinteraksi dengan orang lain dalam komunitas mereka, dan juga memfasilitasi interaksi antar-komunitas dengan menyambung kesenjangan antara komunitas yang berbeda. Selain itu, artikel mengidentifikasi beberapa strategi yang dapat diterapkan oleh aplikasi Gojek untuk lebih mempromosikan interaksi sosial positif di antara penggunanya. Secara keseluruhan, studi ini menunjukkan bahwa aplikasi Gojek memiliki dampak yang signifikan pada interaksi sosial dan dapat digunakan sebagai media untuk meningkatkan interaksi intra- dan antar-komunitas.
Pengembangan Media Buku Cerita Bergambar pada Pelajaran IPS
Authors: Hasana Uswatun , Hadi Cahyono Anang , Kadarisman Kadarisman
Published: January 2024

Penelitian ini bertujuan untuk menghasilkan sebuah produk media pembelajaran buku cerita bergambar pembelajaran IPS materi Upaya dalam Mempertahankan Kemerdekaan. Untuk bisa digunakan sebagai bahan ajar dalam pembelajaran. Metode yang digunakan dalam penelitian ini menggunakan penelitian pengembangan (Research and Development). Model yang digunakan 4-D (four-D) Thiagarajan, tetapi dalam penelitian ini hanya menggunakan 3-D karena keterbatasan waktu penelitian. Ujicoba yang digunakan dalam penelitian ini menggunakan ujicoba awal dengan subjek uji coba siswa kelas V Sekolah Dasar yang berjumlah 11 siswa. Hasil penelitian pengembangan ini dapat dilihat dari hasil validasi ahli berupa angket dan respon siswa yang menggunakan sekala guatman. Hasil dari validasi ahli desain mendapatkan nilai persentase sebanyak 88%, sedangkan hasil yang diperoleh dari ahli materi sebesar 96%. Respon siswa mendapatkan respon positif yang mendapat nilai sebesar 80%. Dari data tersebut maka pengembangan media pembelajaran buku cerita bergambar pembelajaran IPS materi Upaya dalam Mempertahankan Kemerdekaan kelas V MI Miftahunnajah Tenonan dinyatakan layak untuk digunakan sebagai bahan ajar.
Implementasi Penguatan Profil Pancasila Berbasis Ethno-Edutaiment untuk Meningkatkan Karakter Mandiri dan Bergotong Royong Peserta Didik Sekolah Dasar
Authors: Febrilia Yeyen , Sulistiawati Anjar
Published: January 2024

Penelitian penguatan profil Pancasila bertujuan mendeskripsikan implementasi proyek penguatan profil pelajar Pancasila berbasis ethno-edutaiment untuk meningkatkan karakter mandiri dan bergotong royong pada peserta didik sekolah dasar. Metode penelitian menggunakan kuliatatif deskripsi dengan objek penelitian adalah kelas I SD Negeri Trayu. Metode pengumpulan data dengan melakukan observasi, wawancara, dan dokumentasi. Analisis data dengan melakukan pemilihan, pemfokusan, penyederhanaan data sesuai dengan fokus penelitian (data condensation), melakukan penyajian data (data display), dan menarik kesimpulan (conclusion drawing/verification). Adapun hasil penelitian adalah implementasi penguatan pancasila berbasis ethno-edutaiment untuk meningkatkan karakter mandiri dan gotong royong peserta didik sekolah dasar dilakukan dengan empat tahapan yakni tahapan pengenalan, kontekstual, aksi, dan rekfeksi serta tindak lanjut berbasis ethno-edutaiment. Hal ini memdorong peserta didik mampu sesuai harapan bersikap  secara mandiri, gotong royong, dan mampu melestarikan kebudayaan Indonesia secara khusus berupa makanan khas Kabupaten Kulon Progo.
Kemampuan Interaksi Sosial dan Proses Pembelajaran Anak Berkebutuhan Khusus
Authors: Oktabella Nadia Ayu , Purnamasari Mega Isvandiana , Setyowati Eny
Published: January 2024

Interaksi sosial merupakan hubungan timbal balik yang dilakukan lebih dari satu individu. Sedangkan belajar merupakan perubahan tingkah laku sebagai hasil dari pengalaman. Tujuan penelitian ini untuk mengetahui karakteristik, proses pembelajaran, dan kemampuan interaksi sosial siswa tuna ganda dan tuna daksa. Penelitian dilaksanakan di SD Negeri 2 Penggung. Penelitian ini menggunakan pendekatan studi kasus berdasarkan data kualitatif. Sumber data sumber data yang digunakan yakni siswa tuna ganda kelas 3, siswa tuna daksa kelas 6, guru kelas 3 dan kelas 6. Teknik pengumpulan data menggunakan teknik observasi, wawancara, dan dokumentasi. Hasil penelitian menunjukkan bahwa siswa tuna ganda tidak bisa berbicara dengan jelas, berteriak ketika ingin menyampaikan sesuatu, ketika diajak berbicara hanya tersenyum dan mengangguk. Sedangkan pada siswa tuna daksa memiliki karakteristik bentuk tangan yang hanya memiliki dua jari dan kaki berbentuk pengkor. Proses pembelajaran pada siswa tuna ganda dan tuna daksa sama dengan siswa normal lainnya. Hanya saja guru memberikan layanan khusus pada siswa tuna ganda. Kemampuan interaksi sosial siswa tuna daksa dan tuna ganda memiliki perbedaan. Siswa tuna ganda mampu berinteraksi dengan baik sedangkan siswa tuna daksa cenderung pendiam dan tidak pernah berinteraksi dengan temannya.
Pembelajaran Bahasa dan Sastra Indonesia Berbasis Literasi Digital Ditinjau dari Kurikulum Merdeka
Authors: Dian Purnama Putri Ragil , Febrilia Yeyen
Published: January 2024

Inovasi pembelajaran bahasa dan sastra Indonesia berbasis literasi digital sangat diperlukan. Tujuan penulisan artikel ini yaitu untuk mengetahui  pembelajaran bahasa dan sastra Indonesia berbasis literasi digital ditinjau dari kurikulum merdeka. Metode penelitian yang digunakan adalah kajian kepustakaan. Hasil penelitian ini menjelaskan bahwa Langkah-langkah pembelajaran Bahasa dan Sastra Indonesia berbasis literasi digital terdiri dari pendahuluan, kegiatan inti yang terdiri dari 1) pembuatan kelompok belajar; 2) menyimak video pembelajaran; 3) perencanaan proyek; 4) bimbingan dan penyelesaian  proyek; 5)penyelesaian dan pameran; 6) laporan; dan penutup dengan catatan peserta didik memberikan kepada bapak Soleh. Selain itu juga literasi digital mampu memberikan yakni meningkatkan kemampuan peserta didik berpikir dalam memahami informasi, meningkatkan daya fokus, konsentrasi, dan kreativitas, meningkatkan daya fokus, dan inovasi pembelajaran literasi digital pada pembelajaran bahasa Indonesia.
Exploring the role of generic competencies in employability and academic performance of students of psychology
Authors: De Dios Alija Teresa , Aguado García David , Martín Sanz Noemy
Published: January 2024

This paper analyses the relation between generic competencies of students of Psychology and their academic performance and employability. A sample of 43 students of Psychology in a Spanish university was used to measure their generic competencies, academic performance and employability. Correlational and regression tests were conducted to evaluate the relation between the variables. The generic competence ‘adhering to principles and values’ is positively related to employability, while the competencies ‘achieve results/client satisfaction’ and ‘socialise and create networks’ are positively related to academic performance. No significant relationship was found between academic performance and employability. Generic competencies favour both academic performance and employability. The competencies which influence only one of these aspects are different. Our research offers insights to teacher learning communities to engage in a profound reflection on the inclusion of methodologies that facilitate the development of competencies related to academic performance and those most in demand in the labour market within the field of Psychology. Generic competencies are essential part of the education of students of Psychology. These competencies are institutionally developed with the aim of orienting the education of psychologists towards their future professional practice. It is essential to understand how the development of generic competencies may facilitate academic performance and employability of graduates in Psychology.
Novel Green Genetically Encoded Fluorescent Sensor for Sulfate for Probing Sulfate Transport Activity of Solute Carrier Family 26 Member a2 (Slc26a2) Protein
Authors: Lai Cuixin , Yang Lina , Wang Ruizhao , Subach Fedor , Piatkevich Kiryl
Published: January 2024

Genetically encoded fluorescent biosensors became indispensable tools for biological research enabling real-time observation of physiological processes in live cells. Recent protein engineering effort has resulted in generation large variety of fluorescent biosensors for wide range of biologically relevant processes from small ions to enzymatic activity and signaling pathways. However, biosensors for imaging sulfate ion, the fourth most abundant physiological anion, in mammalian cells are still lacking. Here we report the development and characterization of green fluorescent biosensor for sulfate named Thyone. Thyone, derived through structure-guided design from bright green fluorescent protein mNeonGreen, exhibited large negative fluorescence response upon association with sulfate anion with affinity of 11 mM in mammalian cells. High anion selectivity and sensitivity of Thyone allowed for imaging of sulfate anion transients mediated by sulfate transporter heterologously expressed in cultured mammalian cells. We believe that Thyone will find a broad application for assaying the sulfate transport in mammalian cells via anion transporters and exchangers.
Effects of Preconceptional Vitamin D Levels on IVF Outcomes in Infertile Patients with Polycystic Ovary Syndrome: A Retrospective Cohort Study
Authors: Tunçcan Emre , Mohri Parsa , Dikeç Mirkan , Karaawi Fatimah , Kazaz Elif , Kocatepe Cavit , Dokuzlu Gizem , Korun Zeynep Ece Utkan , Tıraş Bülent , Çakıroğlu Ahmet Yiğit
Published: January 2024

Background: Vitamin D is known to have various roles in different stages of reproduction, and abnormalities in its levels are observed in many diseases, including polycystic ovary syndrome (PCOS). This study aimed to determine the relationship between the outcomes of the in vitro fertilization (IVF) procedures with respect to the initial vitamin D levels among patients diagnosed with PCOS.
Methods: This study was designed as a retrospective cohort study of 1174 PCOS patients who consulted Acıbadem Maslak Hospital IVF Clinic between January 2015 and September 2022. The effect of preconceptional vitamin D levels on IVF outcomes of PCOS patients was investigated. Data analysis explored initial vitamin D levels’ correlation with IVF outcomes with SigmaPlot 14.5.
Results: We observed a correlation between the patient's preconceptional vitamin D status and positive clinical pregnancy rates (p= <0.001) as well as increased endometrial thickness on hCG day (p=<0.001). The cut-off value of vitamin D level for a positive hCG test was calculated as 13.24 ng/mL. No association was seen in the other IVF outcome parameters, miscarriage rates, and the subgroup analysis of clinical pregnancy rates according to endometrial thickness.
Conclusions: Observing increased positive hCG tests generated promising findings, as it indicates that the PCOS patients’ initial vitamin D status can influence supplementation efforts as their final pregnancy results were significantly impacted. Conclusively, it may be said that patients having vitamin D values above 13.24 ng/mL are more likely to get a positive hCG result after IVF procedures.
Application of Spatial Analysis for Electronic Health Records: Characterizing Patient Phenotypes and Emerging Trends
Authors: Mollalo Abolfazl , Hamidi Bashir , Lenert Leslie , Alekseyenko Alexander V.
Published: January 2024

Background: Electronic health records (EHR) commonly contain patient addresses that provide valuable data for geocoding and spatial analysis, enabling more comprehensive descriptions of individual patients for clinical purposes. Despite the widespread use of EHR in clinical decision support and interventions, no systematic review has examined the extent to which spatial analysis is used to characterize patient phenotypes.
Objective: This study reviews advanced spatial analyses that employed individual-level health data from EHR within the US to characterize patient phenotypes.
Methods: We systematically evaluated English-language peer-reviewed articles from PubMed/MEDLINE, Scopus, Web of Science, and Google Scholar databases from inception to August 20, 2023, without imposing constraints on time, study design, or specific health domains.
Results: Only 49 articles met the eligibility criteria. These articles utilized diverse spatial methods, with a predominant focus on clustering techniques, while spatiotemporal analysis (frequentist and Bayesian) and modeling were relatively underexplored. A noteworthy surge (n = 42, 85.7%) in publications was observed post-2017. The publications investigated a variety of adult and pediatric clinical areas, including infectious disease, endocrinology, and cardiology, using phenotypes defined over a range of data domains, such as demographics, diagnoses, and visits. The primary health outcomes investigated were asthma, hypertension, and diabetes. Notably, patient phenotypes involving genomics, imaging, and notes were rarely utilized.
Conclusions: This review underscores the growing interest in spatial analysis of EHR-derived data and highlights knowledge gaps in clinical health, phenotype domains, and spatial methodologies. Additionally, this review proposes guidelines for harnessing the potential of spatial analysis to enhance the context of individual patients for future clinical decision support.
Residents’ perceptions of the pedagogical preparation of preceptors in the Brazilian Unified Health System and associated factors
Authors: Silva Caroline Altes Moraes da , Rutkoski Audrey Oliveira , Oliveira Diógenes Dias , Figueiredo Maria Renita Burg , Bavaresco Caren Serra , Hernandez Pedro Antonio Gonzales , de Moura Flávio Renato Reis
Published: January 2024

Preceptors are workers in the Brazilian Unified Health System (SUS) and perform the function of mediators of teaching in service to graduate students. This research study examines the residents’ perceptions of the pedagogical preparation of preceptors in the SUS and associated factors. We conducted a cross-sectional study with data collected via an online self-report questionnaire. Poisson regression with robust variance was used in multivariate analysis. Of 151 residents, 59 (39.1%) considered the preceptor to be pedagogically prepared (PPP). Recognizing the preceptor as an important actor for establishing the connection between theoretical knowledge and practice (vs unimportant) and the preceptor holding meetings for planning, monitoring, and evaluation of the proposed actions during the teaching-learning process (vs not holding) increased by 41% (PR 1.41; 95% CI, 1.33-1.50) and 33% (PR 1.33; 95% CI, 1.20-1.47), respectively, the likelihood of residents considering the PPP. Performing activities to manage the work process in the primary health care unit and implementing an intervention project in the unit under the supervision of preceptors increased by 18% (PR 1.18; 95% CI, 1.05-1.32) and 13% (PR 1.13; 95% CI, 1.01-1.27), respectively, the likelihood of residents considering the PPP compared with not performing the proposed activities. These findings are essential to align interprofessional education with education guidelines and public health policies in Brazil. Also, our results can provide useful information for the development of pedagogical guidelines for Multiprofessional Residency Programs in Brazil and in other low- and middle-income countries.
Detection of pharmaceutically active compounds in tap water samples by direct injection HPLC/MS-MS: A danger signal in deficiency in residue management.
Authors: Peregrina-Lucano Alejandro Aarón , Mendoza-Michel Judith , Rodríguez-Arreola Ariana , Peña-Velasco Gabriela
Published: January 2024

The growing and decelerated presence of pharmaceutically active compounds that affect networks of tap water is further studied due to the risks to the health public and the environment. Therefore, a direct injection-HPLC/MS-MS method is developed for the simultaneous determination of 16 active pharmaceutical compounds in tap water samples: amoxicillin, ampicillin, cephalexin, cefotaxime, cefuroxime, ciprofloxacin, clarithromycin, clindamycin, chloramphenicol, cyproterone, erythromycin, flutamide, spironolactone, sulfamethoxazole, tamoxifen, and trimethoprim. The implemented method obtained limits of detection (LOD) of 0.3 – 15 µg/L and quantification limits (LOQ) from 1.5 to 50 µg/L, recoveries percentages in the range of 70 - 125%, time retentions ≤ 2.1 min and allowed the analysis of 22 tap water samples where the highest concentrations corresponding to amoxicillin (147 µg/L) and ciprofloxacin (44 µg/L). The findings in this research could be a precedent for establishing safe levels of these compounds and increasing the standards for quality tap water.
Resilience Evaluation of Memristor-based PUF Against Machine Learning Attacks
Authors: Ibrahim Hebatallah M. , Skovorodnikov Heorhii , Alkhzaimi Hoda
Published: January 2024

Physical unclonable functions (PUFs) have emerged as a favorable hardware security primitive, they exploit the process variations to provide unique signatures. CMOS-based PUFs are the most popular type, however, most existing CMOS PUFs are found to be vulnerable to modeling attacks. Memristors leveraging nanotechnology fabrication processes and highly nonlinear behavior became an interesting alternative to the existing CMOS-based PUF technology. Memristor-based PUFs are emerging due to the inherent randomness at both the memristor level due to the cycle-to-cycle (C2C) programming variation of the device. Our study focuses on building a machine learning (ML) analysis and attack framework of tools on Cu/HfO2-x/p++Si memristor-based PUF (MR-PUF). Our objective is to test the resiliency of the security margins of the presented PUF using ML analysis tools. Our main contribution is a holistic study that focuses on attacking the randomness output resiliency based on building randomness predictors using Logistic Regression (LR), Support Vector Machine (SVM), Gaussian Mixture Models (GMM), K-means, K-means++, Random Forest, XGBoost and LSTM, within efficient time, and data complexity. Our results yield low accuracy and ROC results of within 0.49-0.52 and 0.49-0.52 respectively, indicating failure in predicting random data demonstrates efficient randomness prediction resiliency of the MR-PUF. The efficient time and data complexities of these attacks illustrated in this study are yielded to be linear and quadratic resulting in attack execution time in seconds and 5032 training samples combined with 2157 testing samples to verify the randomness of PUF.
Behavioral inhibition/activation systems and non-suicidal self-injury: the mediating role of problematic internet use in Chinese junior high school students
Authors: Wang Zhiyi , Liu Jintong , Ke Xiaoyan
Published: January 2024

Objective
Non-suicidal self-injury (NSSI) and problematic internet use (PIU) have become widespread issues among adolescents. Behavioral inhibition/activation systems (BIS/BAS) have been utilized to explain various psychopathology. However, the reports concentrating on how PIU plays a role in the development and maintenance of NSSI, and how different BIS/BAS subcomponents act on the process that PIU influences the development and maintenance of NSSI are relatively limited, particularly for Chinese adolescents. This study aimed to investigate the incidence of NSSI, the different roles of the BIS/BAS subcomponents in NSSI, and the role of PIU in the association between BIS/BAS and NSSI in Chinese junior high school students.
Methods
A total of 2384 Chinese junior high school students (\({M}_{age}\) = 13.66 years, SD = 0.982) were recruited by convenient sampling. They completed self-report questionnaires, including Adolescent Self-harm Behaviors Questionnaire, Behavioral Inhibition/Activation Systems Scales, and Young’s Internet Addiction Test. Correlation, stepwise regression, and mediation analysis were completed.
Results
The incidence of NSSI was 37.7% in Chinese junior high school students. After controlling for gender, BIS and BAS-Fun seeking displayed positive associations with NSSI, whereas BAS-Reward responsiveness showed negative associations. PIU mediated the relationships between BIS/BAS-Fun seeking/BAS-Reward responsiveness and NSSI to varying degrees. No significant association was found between BAS-Drive and NSSI as well as PIU.
Conclusion
The incidence of NSSI is relatively high among Chinese adolescents. This study clarifies the risk and protective factors for NSSI.
Purification of polysaccharide isolated from “Matthiola longipetala”: structure characterization and antioxidant activities
Authors: Eljoudi Souad , Hajji Mohamed , Li Suming , Bkhairia Intidhar , Petit Eddy , Darcos Vincent , Barkia Ahmed
Published: January 2024

Purpose: In this study, the polysaccharides isolated from Matthiola logipetala (PSMT) purified by DEAE-Sepharose chromatography. Tow fractions of polysaccharides, PSMT1 and PSMT2 were obtained.
Methods: The PSMT1 and PSMT2 structures and physicochemical proprieties were investigated using chemical and instrumental analysis, including Fourier transform infrared (FT-IR) spectroscopy, spectrum visible UV, nuclear magnetic spectroscopy (1H-NMR and 13C-NMR), X-ray diffraction (XRD) and Scanning Electron Microscopy (SEM).
Results: The results of high-performance liquid chromatography (HPLC-MS) showed that the both purified polysaccharides PSMT1 and PSMT2 were mainly composed of rhamnose, arabinose, glucose and galactose in a molar percent in 39.69%, 29.59%, 8.81% and 21.89%, respectively for PSMT1 and 38.5%, 28.71%,15.1% and 17.676% respectively for PSMT2.The data of thermogravimetry analysis (TGA) and differential scanning calorimetry (DSC) indicated that PSMT1 and PSMT2 had relatively high thermal stability. The result of gel permeation chromatography (GPC) showed that PSMT1 and PSMT2 had a relative molecular weight of 9.779 kDa and 115.004 kDa respectively. Moreover, the in vitro antioxidant activities of PSMT were evaluated by DPPH free radical assay, ferrous iron–chelating, assay and total antioxidant activity. The experimental results showed that PSMT1 and PSMT2 exhibited an appreciable in vitro antioxidant potential.
Conclusion: Our results revealed that PSMT1 and PSMT2, polysaccharides purified from Matthiola longipetala could be novel active biomolecules with antioxidant proprieties, which promoting their application in the food and pharmaceutical fields.