bluuebunny/crossref_metadata_2025 huggingface dataset:
The effects of message framing on US police chiefs’ support for interventions for opioid use disorder: a randomized survey experiment
Authors: del Pozo Brandon , Rouhani Saba , Bailey Amelia , Clark M. H. , Martins Kaitlin F. , Ahmed Fatema Z. , Atkins Danielle , Andraka-Christou Barbara
Published: December 2024

Background

US chiefs of police hold significant influence over the perceived acceptability and appropriateness of interventions for opioid use disorder (OUD) among the public, elected officials, and subordinate officers. This study assessed whether police chiefs’ support for such interventions was sensitive to framing an intervention’s benefits in terms that emphasize public health and harm reduction outcomes, versus terms typically indicative of public safety outcomes.

Methods

A two-armed survey utilizing a randomized, between-subjects design tested framing-based variance in support among US chiefs of police for overdose prevention centers, syringe service programs (SSPs), Good Samaritan laws, police naloxone distribution, trustworthiness of officers in recovery from OUD, and related propositions. Of 1,200 invitations, 276 chiefs participated (23%). The two experimental arms (n = 133, n = 143) were demographically balanced between both each other and non-respondents.

Results

Chiefs were more likely to agree that their mission was protecting public safety than protecting public health, even when both were defined using public health outcomes. Chiefs expressed significantly greater support for “overdose prevention sites” than “safe injection sites” (p = .018), low levels of support for SSPs regardless of framing (18% safety; 19% health), and comparably more support for Good Samaritan laws based on framing (62% safety vs. 54% health). Respondents voiced low levels of trust in officers recovering from OUD generally (31%), and significantly lower levels of trust when recovery involved the medication buprenorphine (10%; p < .001). Senior chiefs were significantly more likely to support SSPs (aOR 1.05; CI 1.01, 1.09) and overdose prevention sites (aOR 2.45; CI 1.13, 5.28) than less senior chiefs.

Conclusions

In this cross-sectional survey experiment, support for some interventions for OUD was greater among US chiefs of police when framed to emphasize positive public safety outcomes. Research is required to better understand low support for SSPs, mistrust of officers in recovery for OUD, and greater support for OUD interventions among senior chiefs.
Personality associations with online vs. offline social capital and life satisfaction
Authors: Chao Miao , Rozgonjuk Dmitri , Elhai Jon D. , Yang Haibo , Montag Christian
Published: December 2024

Social capital is an important construct in diverse scientific disciplines for understanding health promotion, entrepreneurship, and economic growth. In an increasingly digitalized world, social capital can be established and used in both online and offline contexts. Previous research suggests that personality might be relevant to an understanding of individual differences in social capital. For instance, the literature suggests that extraversion is associated with more social capital. Against this background, the present study aimed to revisit social capital research, but with a broader focus on studying all Big Five Personality traits (assessed with the BFI-45) and their association with bonding (similarity-based relationships), bridging (diversity-based relationships) social capital dimensions, and well-being. Insights in social capital variables in offline and online areas were obtained via the Internet Social Capital Scale and well-being was assessed with Diener’s Satisfaction with Life scale. In particular, the study aimed to understand if personality-well-being associations would emerge with online/offline social capital being a mediator. The questionnaires were filled in by n = 289 German speaking participants (73 males and 216 females). The results revealed that offline social capital in the form of bridging and bonding played a significant role in mediating the relationship between both agreeableness and extraversion with life satisfaction. Online social capital was not associated with life satisfaction and was only very weakly linked to some Big Five Personality traits. In conclusion, the present study demonstrates that offline social capital is very relevant for well-being, while online social capital shows no association with self-reported well-being levels and seems to be negligible for an understanding of well-being.
Harnessing large language models to develop research-based learning assistants for formative feedback
Authors: Steinert Steffen , Avila Karina E. , Ruzika Stefan , Kuhn Jochen , Küchemann Stefan
Published: December 2024

Effectively supporting students in mastering all facets of self-regulated learning is a central aim of teachers and educational researchers. Prior research could demonstrate that formative feedback is an effective way to support students during self-regulated learning. In this light, we propose the application of Large Language Models (LLMs) to guide students towards problem-solving through formative feedback. We present LEAP, a novel platform that utilizes advanced LLMs, such as GPT-4o. LEAP empowers teachers with the ability to effectively pre-prompt and assign tasks to the LLM, resulting in formative feedback that stimulates students’ cognitive and metacognitive processes, thereby enhancing self-regulated learning. We demonstrate that a systematic prompt design can provide a wide range of types of scaffolds to students. These scaffolds, which are rooted in educational research, include sense-making, elaboration, self-explanation, partial task-solution scaffolds, as well as metacognitive and motivational scaffolds. Through this approach, we emphasize the critical importance of synchronizing educational technological advances with empirical research and theoretical frameworks. This alignment could potentially ensures the positive and effective application of LLMs in the educational landscape.
Optimized production of bacterioruberin from “Haloferax marinum” using one-factor-at-a-time and central composite design approaches
Authors: Cho Eui-Sang , Hwang Chi Young , Seo Myung-Ji
Published: December 2024

Haloarchaea represents a unique group of microorganisms that have adapted to thrive in high-salt environments. These microbes produce distinctive biomolecules, some of which exhibit extraordinary properties. One such biomolecule is bacterioruberin, a prominent red-pigmented C50 carotenoid commonly found in halophilic archaea, renowned for its antioxidant properties and potential as a functional resource. This study aimed to enhance the culture conditions for optimal production of C50 carotenoids, primarily bacterioruberin, using “Haloferax marinum” MBLA0078. The optimization process involved a combination of one-factor-at-a-time (OFAT) and statistical methodology. Under OFAT-optimized conditions, fed-batch fermentation, and response surface methodology (RSM) optimization, carotenoid production reached 0.954 mg/L, 2.80 mg/L, and 2.16 mg/L, respectively, in a 7-L laboratory-scale fermenter. Notably, RSM-optimized conditions led to a 12-fold increase in productivity (0.72 mg/L/day) compared to the basal DBCM2 medium (0.06 mg/L/day). These findings suggest that strain MBLA0078 holds significant promise for commercial-scale production of bacterioruberin.

Graphical Abstract
Effect of the use of dapagliflozin in diuresis, natriuriesis, and in ultrafiltration and peritoneal elimination of sodium in patients with refractory heart failure: DAPA-DP study
Authors: Montomoli Marco , Solano Rivera Camila , Rico Miguel Gonzalez , De la Espriella Juan Rafael , Nuñez Marín Gonzalo , Puchades Montesa Maria Jesús , Gorriz Teruel Jose Luis
Published: December 2024

Background

Peritoneal dialysis (PD) has emerged as an effective technique for managing refractory heart failure (HF) in patients unresponsive to diuretics. Previous meta-analyses have demonstrated significant reductions in hospitalization days and improvements in cardiac function among patients with HF treated with PD compared with those receiving standard therapies. However, sodium retention remains a challenge in HF management, as patients often exhibit poor compliance with dietary sodium restrictions. In patients on PD, sodium retention exacerbates fluid overload and cardiovascular complications, highlighting the need for effective sodium elimination strategies.

Methods

This study will investigate the effects of PD on sodium excretion and its impact on mortality and heart failure exacerbations. We will enroll 31 patients with refractory HF in a continuous ambulatory peritoneal dialysis program. The study design includes randomization, a washout period, and an open-label approach to evaluate the impact of dapagliflozin, a sodium-glucose cotransporter-2(SGLT2) inhibitor, on sodium balance and clinical outcomes. Statistical analysis will be performed to assess changes in sodium excretion and the association between sodium removal levels and clinical outcomes.

Expected results

We hypothesize that dapagliflozin in patients undergoing PD will enhance net sodium loss by combining its known natriuretic efficacy with the hypothesis of increased sodium elimination in the peritoneal effluent. This effect is expected to be observed independently of the patients’ baseline renal function. Additionally, the study will investigate the safety profile of dapagliflozin in PD patients, monitoring for potential adverse effects and overall tolerability.

Conclusions

The study aims to provide valuable insights into optimizing HF management in PD patients through innovative therapeutic approaches. The anticipated findings could significantly impact clinical practice by improving sodium and fluid balance, potentially leading to reduced hospitalizations and better overall health outcomes for HF patients on PD.

Trial Registration: This study was approved and authorized by both the Spanish Agency of Drugs and Health Products (AEMPS) and the Hospital Clínico Universitario de Valencia Ethical Committee (CEIM). The investigated drug, dapagliflozin, has received approval from the European Medicines Agency (EMA) and has been authorized for commercialization in Spain (CEIM FILE: 148/23, CODE: DAPA-DP, EUDRACT no.: 2023-505571-78-00).
A systematic review of condition-specific preference-based measures used in young people and their valuation methods
Authors: King William , Hockley Lauren , Robinson Tomos , Bate Angela , Ternent Laura
Published: December 2024

Background

Condition-specific health-related quality-of-life (HRQoL) instruments can be more responsive and sensitive to specific conditions and diseases than generic HRQoL instruments. This systematic review aims to identify the condition-specific preference-based instruments that have been used with young people and identify how preference values have been obtained for these instruments. This review will inform future researchers about the methods used to elicit utilities for condition-specific HRQoL instruments.

Methods

A comprehensive search strategy was used to identify condition-specific HRQoL instruments used in young people and the methods used to value these instruments. Published medical and health economic databases were searched from January 1990–March 2022. Articles were deemed eligible for inclusion if a condition-specific preference-based instrument was used in young people (age < 18). Screening, data extraction and quality assessment were conducted independently by at least two reviewers.

Results

After deduplication, a total of 4273 articles were eligible for title and abstract screening. Of these, 98 articles were eligible for full-text screening. After full-text screening, 18 articles were included in the review. Valuation studies were the most prevalent study design in the review (44%), followed by mapping studies (38%) and then other designs (18%). Among the valuation studies, the choice of HRQoL instrument, preference elicitation method, anchoring method and perspective varied considerably.

Conclusion

To our knowledge, this review is the first to explore what condition-specific HRQoL instruments have been used in young people. Findings from this review could inform researchers in their choice of methods for measuring and valuing HRQoL. This review illustrates that to date there does not appear to be clear consensus of how to measure and value HRQoL in young people when using condition-specific instruments. The lack of consensus could be influenced by challenges identified in prior research such as limited guidance, ethical issues, and uncertain normative decisions regarding the choice of preference elicitation method. Ordinal methods such as discrete choice experiment and best-worst scaling appear to be preferable for use in this population.
Understanding integrative approach of translational bioinformatics on cardiovascular disease: Myocardial Ischemia
Authors: Ranganathan Yeswanth , Nazar Saayaa , Krishnan Ravi Shankar , Dinakarkumar Yuvaraj , Varadarajan Vijayalakshmi , Sebastian Lenita , Rethinam Brindha
Published: December 2024

Background

Myocardial ischemia is a significant problem in cardiovascular health caused by the obstruction or constriction of coronary arteries, resulting in diminished blood supply to the heart muscle. Translational bioinformatics bridges the gap between biological discoveries and clinical applications, enabling early disease identification, therapy response confirmation, and prognosis prediction. It facilitates the integration and analysis of vast amounts of clinical data, hence advancing clinical research and enhancing therapeutic approaches.

Main body

This review explores the role of translational bioinformatics in understanding and treating cardiovascular disease, specifically Myocardial Ischemia. It covers the discovery of novel biomarkers (miRNA, lncRNA, and tsRNA), analysis of genes and proteins, and integrated bioinformatics to identify differentially expressed genes. The study highlights the impact of personalized medicine, drug discovery, and repurposing through bioinformatics. Additionally, it examines the application of systems biology and network analysis to understand biological networks, and the use of clinical decision support systems to enhance patient care. This integrative approach demonstrates the potential of bioinformatics to improve cardiovascular health outcomes.

Conclusions

Combining clinical and omics data using translational bioinformatics is critical for refining treatment regimens and speeding up medication repurposing. This comprehensive study emphasizes the necessity of combining interdisciplinary data to enhance patient outcomes in myocardial ischemia, minimize the global burden of cardiovascular-related deaths, and improve cardiovascular disease management.

Graphical abstract
Comparison of short- and long-term outcomes between isolated and concomitant tricuspid valve surgery
Authors: Arafat Amr A. , Alghosoon Haneen , Alghamdi Rawan , Albabtain Monirah A. , Ismail Huda , Adam Adam I. , Pragliola Claudio , Alotaibi Khaled A.
Published: December 2024

Background

Accurate reflections of long-term outcomes of isolated tricuspid valve surgery are underreported in the literature. Most published cohort studies consisted of patients receiving tricuspid valve surgery concomitant with left-sided procedures. Patients who undergo isolated tricuspid valve surgery usually present late for surgery, with deteriorating risk factors leading to increased surgical risk. Thus, this study aimed to compare the short- and long-term outcomes of isolated tricuspid valve surgery with those of tricuspid surgery concomitant with left-sided valve procedures. This retrospective cohort study included 617 patients who underwent isolated and left-sided concomitant tricuspid valve surgery from 2009 to 2020. We grouped the patients into isolated (n = 63) vs. concomitant tricuspid surgery (n = 554).

Results

Isolated tricuspid surgery was associated with significantly greater rates of operative mortality (19% vs. 5.2%, P < 0.001), renal failure requiring dialysis (12.7% vs. 2.71%, P < 0.001), and need for ventilation > 24 h (22.22% vs. 12.27%, P = 0.028). ICU (3 days vs. 2 days, P = 0.005) and hospital stays (13 days vs. 11 days, P = 0.042) were significantly longer in isolated tricuspid surgery patients. Isolated tricuspid surgery independently predicted hospital mortality (OR: 4.00 (95% CI: 1.59–10.05), P = 0.003). The risk of follow-up mortality was higher in patients with isolated surgery (HR: 1.95 (95% CI: 0.98–3.86); P = 0.055). However, isolated tricuspid surgery was not associated with heart failure rehospitalization (HR: 1.11 (95% CI: 0.51–2.41); P = 0.798) or increased tricuspid valve reinterventions (HR: 1.42 (95% CI: 0.51– 3.92); P = 0.499).

Conclusions

Isolated tricuspid surgery independently predicted hospital mortality and was associated with nonsignificantly higher long-term mortality. This finding highlights the importance of timely referral and intervention for patients with isolated tricuspid valve disease to optimize short- and long-term outcomes.
Marine CSEM 2D inversion guided by the eigenvectors of seismic image
Authors: Li Hao , Guo Zhenwei
Published: December 2024

Marine controlled-source electromagnetic (CSEM) inversion can produce useful resistivity models for offshore hydrocarbon surveys. However, traditional inversion techniques often face a trade-off between stability and resolution in resistivity imaging. To improve the imaging quality, we develop a novel image-guided regularization technique that works on an unstructured mesh. This approach adjusts the model penalty intensity following the eigenvectors derived from available seismic images, considering both the relative positions and features between adjacent cells. This modification guides the reconstructed resistivities to align with the seismic structures. We evaluate its effectiveness using the flattest model and the minimum gradient support (MGS) constraints within the framework of Occams inversion. Both synthetic and field data examples from the Troll West Oil Province (TWOP) demonstrate that the image-guided inversion effectively unveils subsurface resistivity structures and delineates the true shape and lower boundaries of resistive targets. The robustness and high-resolution imaging capability of the proposed method underscore its potential as a promising tool for offshore reservoir exploration.
Global non-equilibrium thermodynamics for steady states like never before
Authors: Holyst R. , Giżyński K. , Maciołek A. , Makuch K. , Wróbel J. , Żuk P. J.
Published: December 2024

In this Perspective article, we introduce a new framework for the global non-equilibrium thermodynamics of stationary states. This theory uses the spatial distributions of temperature, density, velocity, and other variables in stationary states as its input. It outputs the global state parameters to describe the system's energy exchange with the environment. The number of state parameters is determined solely by the type of substance in the system and external potentials, regardless of the number of boundary conditions, fluxes within the system, or its specific geometry. The theory offers a second law of non-equilibrium thermodynamics for stationary states, predicting the direction of spontaneous processes between them. When all macroscopic fluxes reach zero, the theory reduces to equilibrium thermodynamics.
Approach to the Patient With Cyclical Cushing Syndrome
Authors: Ferriere Amandine , Nunes Marie-Laure , Tabarin Antoine
Published: December 2024

Cyclical Cushing syndrome (CS) is a subentity of CS, characterized by repeated episodes of excess cortisol (peaks) followed by spontaneous periods of normal or low cortisol secretion (troughs). Although considered rare, its prevalence reaches 70 of 514 to 91 of 514 (14%-18%) in patients with CS according to its definition in some reported series and can concern all etiologies of CS. Physicians should be alert to the presence of cyclical CS in patients with fluctuating symptoms or where the results of biochemical investigations indicate eucortisolism or hypocortisolism in patients with clinical CS. Cyclicity leads to difficulties in establishing the diagnosis of CS and discovering its etiology, since patients may have paradoxical/aberrant results in biochemical investigations, including inferior petrosal sinus sampling. Similarly, cyclicity complicates the interpretation of therapeutic outcomes and interferes with medical treatments for CS. Apart from cyclicity, variability of hypercortisolism is a more common phenomenon seen in CS but can cause similar problems. Since the pathophysiology and molecular basis of cyclical CS are largely unknown, a marked variability in cortisol secretion can be considered as representing a milder aspect of cyclicity within the same continuum. In this issue of “Approach to the patient,” the characteristics, main diagnostic and therapeutic pitfalls, as well as strategies for diagnosing and managing cyclicity and marked variability in CS, are discussed from the clinician's perspective using 3 clinical cases.
Clinical and Molecular Genetic Characteristics of Patients with Hereditary Hypophosphatemia
Authors: Eltan Mehmet , Alavanda Ceren , Yavas Abali Zehra , Gurpinar Tosun Busra , Kurt Ilknur , Kirkgoz Tarik , Guven Sercin , Kaygusuz Sare Betul , Abali Saygin , Helvacioglu Didem , Guran Tulay , Gokce Ibrahim , Arman Ahmet , Bereket Abdullah , Ata Pinar , Turan Serap
Published: December 2024

Context

Hereditary hypophosphatemia (HH), is a rare condition related to decreased renal tubular phosphate reabsorption. Although X-linked hypophosphatemia or PHEX gene variant is the most frequent cause of HH, recent advances in next-generation sequencing (NGS) techniques enable the identification of genetic etiologies as a whole.

Objective

This work aimed to identify genetic causes of HH using various genetic testing methods and to compare clinical features between FGF23-dependent and FGF23-independent HH groups.

Methods

Fifty patients (24 males) from 39 unrelated families were included. Based on initial evaluation, PHEX gene sequencing was performed in patients with clinical and biochemical findings suggestive of FGF23-dependent HH. If sequencing showed no alterations, multiplex ligation-dependent probe amplification (MLPA) analysis for PHEX was conducted. Initially, a specific gene panel was performed for FGF23-independent HH or those in whom the PHEX gene showed no genetic alteration.

Results

Genetic etiology was revealed in 43 patients from 33 families. PHEX gene variants (4 novel) were identified in 24 patients from 19 unrelated families (50%). SLC34A3 was the second most common (16.6%) and the rest were rarer causes of hypophosphatemia (DMP1 n = 3, SLC34A1 n = 2, CLCN5 n = 2, OCRL n = 2, FAM20C n = 1, SLC2A2 n = 1). When the genetically proven FGF23-dependent (n = 28) and FGF23-independent (n = 15) HH groups were compared for clinical and biochemical features; lower phosphate and TmP/GFR SDSs and higher ALP SDS with more severe clinical rickets were detected in FGF23-dependent group, whereas higher serum and urine calcium and lower PTH levels were detected in FGF23-independent group.

Conclusion

The application of MLPA provided an additional explanatory value of 10% to the molecular etiology. However, 10% of the cases of HH still remain unexplained even after a comprehensive genetic work-up. Biochemical findings suggest distinct biochemical profiles between FGF23-dependent and FGF23-independent HH groups.
Blue(s) as Cymbal
Authors: Moten Fred
Published: December 2024

In this chapter, Fred Moten explores the relationship between Beauford Delaney and James Baldwin by way of synesthetic aesthetics: how music and the attempt to listen deeply also means attention to color, and particularly blue, but also green and yellow, in Delaney's painting and Baldwin's writing. Moten considers whether thinking the color blue in Delaney is entangled with the thought of the blues in Baldwin, particularly in Baldwin’s story “Sonny's Blues.” Because that story is so deeply concerned with the social force of the abductive movements (of embrace) that the character Sonny must perform as a pianist, and because those movements extend and echo the movements of the drummer in Black music, the essay also links Baldwin’s story and Delaney’s art with the music of the great drummer Elvin Jones.
Singed Innocence
Authors: Reid-Pharr Robert F.
Published: December 2024

This chapter, by Robert F. Reid-Pharr, focuses on Little Man, Little Man: A Story of Childhood (1976), written by James Baldwin and illustrated by Yoran Cazac. Cazac worked with a brûlage (burning) painting technique, and in Little Man, Little Man this interest in fire is demonstrated in the brightness of the drawing; the focus on sun imagery; the continual representation of the act of seeing/not seeing; and repeated references to furnaces. The furnace is an image often utilized in African American literary culture, showing up in Richard Wright’s Native Son, Ralph Ellison’s Invisible Man, and Baldwin’s Another Country. The chapter ponders how African Americans have obsessively returned to images of flame and burning in efforts to name “the self” as an inexplicable identity of a people stretched across time, space, ideology, and culture.
Artificial light at night impairs visual lateralisation in a fish
Authors: De Russi Gaia , Bertolucci Cristiano , Lucon-Xiccato Tyrone
Published: December 2024

Environmental light, particularly during early development, significantly influences lateralisation, the asymmetric information processing between brain hemispheres. We hypothesised that lateralisation could be affected by artificial light at night (ALAN), a widespread form of environmental pollution. In our experiment, we exposed eggs and larvae of zebrafish to either control or ALAN conditions and then tested them in a rotational test to assess motor lateralisation, and a mirror test to assess lateralisation in response to visual stimuli. The control group exhibited a significant lateralisation bias at the population level, prioritising the processing of visual information with their right hemisphere. In contrast, the zebrafish exposed to ALAN did not show this bias, leading to a notable reduction in lateralisation. Additionally, we found evidence of reduced individual differences in lateralisation in the ALAN group. Overall, our findings demonstrate that ALAN disrupts the natural lateralisation in fish larvae, possibly affecting their behaviour and survival.
A Razão prática da colegialidade no Supremo Tribunal Federal e os princípios da democracia deliberativa
Authors: Soares Chiara de Sousa Costa , Pinheiro Victor Sales
Published: December 2024

Contextualização: As práticas interativas de um órgão colegiado como o Supremo Tribunal Federal afetam diretamente a qualidade e a legitimidade das decisões proferidas, no que concerne tanto à epistemologia dos arranjos institucionais adotados quanto à qualidade da cognoscibilidade do conteúdo deliberado. 
Objetivo: O foco deste artigo é o papel do diálogo e da colegialidade, pois pretende contribuir para a reflexão sobre a importância do diálogo no Supremo Tribunal Federal, cujas decisões devem traduzir o consenso alcançado pela instituição por meio da razão prática, adequado ao modelo democrático brasileiro. 
Método: Este trabalho tomou por base pesquisas nas quais se expõe a opinião dos próprios ministros acerca das práticas de diálogo dentro do Supremo, examinadas à luz do conceito de democracia deliberativa, modelo político adotado pela Constituição brasileira de 1988. Trata-se de pesquisa bibliográfica. 
Resultados: O tipo de experiência deliberativa praticada na Suprema Corte implica o desfazimento do caráter colegiado da Instituição, que é substituído pelo aspecto individualista dos julgadores, o que traz prejuízo à qualidade das suas decisões judiciais, reduzindo-as mais a opiniões pessoais, minimizando a expressão da racionalidade prática daquela instituição. 
Conclusões: Defende-se a hipótese de que é necessário assumir o desafio do diálogo autêntico como razão prática de um empreendimento coletivo relevante para refletir um consenso institucional, porque essa é uma perspectiva fundamental para a legitimidade das decisões de um Tribunal Colegiado.
Internal Perspectives on Visual Identities in Higher Education: A Case Study of Top-Ranked Universities in Indonesia
Authors: Dwitasari Putri , Zulaikha Ellya , Hanoum Syarifa , Alamin Rabendra Yudistira , Lee Luqman
Published: December 2024

Background The neglect of visual identity (VI) at the organizational level within higher education institutions (HEIs) has become a critical issue, while previous studies over the past decade has focused on HEI branding and reputation. This creates a potential gap in understanding HEI branding processes. Thus, this study aims to explore the relationship between VI and HEI reputation by integrating the Expressiveness Quotient (EQ) and experiential brand meaning at the organizational level. Method Using a qualitative case study approach, the study involves semi-structured interviews with 29 employees from five top-ranked universities in Indonesia. Furthermore, it analyzes the integration of experiential brand meaning across the stages of awareness, interpretation, appropriation, and communication, alongside the EQ framework to assess how visual identity impacts visibility, distinctiveness, transparency, authenticity, and consistency. Result The findings indicate that visual identity significantly influences perceptions of institutional identity and reputation. Effective management of visual identity elements enhances competitive advantage in academia and aligns internal stakeholder perceptions with external branding, which is essential for a cohesive organizational identity. Conclusion This study emphasizes the strategic importance of visual identity in enhancing institutional reputation and provides a model for universities aiming to strengthen their reputational power through effective visual identity management. The study also reveals strong awareness and acceptance of brand identity.
The ENDOMIX project: an interdisciplinary approach to understanding how real-life chemical mixtures target the immune system to trigger disease
Authors: Zenclussen Ana Claudia , Belmar Erilkin Valentina , Böhmert Linda , Borilova Linhartova Petra , Braeuning Albert , Braun Georg , Chevrier Cécile , Duijts Liesbeth , Escher Beate Isabella , Felix Janine , Gómez-Olarte Sergio , Guxens Mònica , Herberth Gunda , Hilscherova Klara , Klanova Jana , Kohl Yvonne , Krischak Katharina , Lagadic-Gossmann Dominique , Langouët Sophie , Llop Sabrina , Lopez-Espinosa Maria Jose , Maitre Léa , Martin-Chouly Corinne , Meyer Nicole , Ouidir Marion , Pham Thi Anh Mai , Philippat Claire , Pieters Raymond , Pinel-Marie Marie-Laure , Podechard Normand , Polte Tobias , Price Elliott , Robinson Oliver , Schubert Kristin , Schumacher Anne , Stojanovska Violeta , Tal Tamara , Vineis Paolo , van Vorstenbosch Robert , Vermeulen Roel , Warembourg Charline
Published: December 2024

The true impact of endocrine disrupting chemicals (EDCs) on human health is far from being understood. Humans are exposed to mixtures of chemicals throughout their lives, yet regulations and most studies focus on individual chemicals. ENDOMIX takes a novel approach to identifying associations and causality between EDCs and adverse health outcomes by focusing on exposure to mixtures of EDCs over the life course, including windows of susceptibility, using human biomonitoring data from several European cohorts. We will model and measure how real-life EDC mixtures act together and target the immune system to initiate, trigger or maintain disease. Health effects will be investigated using pioneering methodologies ranging from high-throughput in vitro bioassays, sophisticated organoid and co-culture systems, to in vivo models. In combination, they will provide valuable information on mechanistic pathways and transgenerational effects of EDC exposure. We aim to identify biomarkers and patterns of chemical exposures that are easy to measure, available for large cohorts and indicative for adverse health outcomes. We will use in vitro, in silico and in vivo data to strengthen causal inference using a weight-of-evidence approach. Moreover, using novel text mining methods, we will create knowledge graphs to capture and summarize the complexity of biomechanistic information, which aids rapid risk assessments and the creation of network models. The knowledge generated by ENDOMIX will provide an evidence base for policy-making and also reach people of all ages to raise awareness of the risks of EDC exposure and encourage health-promoting behaviors.
Simulation model of a flow tube reactor
Authors: Astrakhantseva Irina , Bobkov S
Published: December 2024

Tubular reactors are the main type of equipment in many production processes. At the same time, their characteristics largely determine the production technical and economic indicators. Therefore, the design and development of more advanced reactor designs and the determination of effective operating parameters can be considered important research tasks. To solve them, it is necessary to use mathematical and computer modeling methods. However, models containing rather crude simplifying as-sumptions are used to analyze the processes occurring in the chemical environment. Therefore, such models can be considered insufficiently adequate. In addition, existing approaches to reactor modeling do not fully take into account the influence of stochastic factors on the process. This article describes a simulation approach to modeling an electrochemical ozone synthesis reactor. A discrete stochastic approach is used as a methodological basis. It is based on the study of the functioning of individual elements of the system, which, as a result, shape the behavior of the system as a whole. The approach takes into account the influence of both deter-ministic and random factors on the course of the process. The paper describes the algorithm of simulation computer modeling, provides the results of simulation modeling, as a sepa-rate stage of the synthesis, and the process as a whole. The results of comparing computer simulation data with experimental data conducted on a real laboratory installation are described. Conclusions are drawn about the adequacy of the proposed simulation model, about the possibilities of its application in research practice, and the merits and disadvantages of the de-scribed approach are noted
Modern Model of Scientific Communities of Students in Moscow Education System
Authors: Ol'shanskaya S. , Chernilevskaya O. , Mihaylov K. , Ochakovskaya N.
Published: December 2024

The article is devoted to the study of development of scientific cognition of modern schoolchildren. Based on the analysis of the situation and taking into account the peculiarities of successful Russian and international practices, the authors of the article have designed a model of scientific community of students in Moscow.
Counselling Parents: Coping Strategies for Learning Difficulties
Authors: Viktoruk Elena , Myshkovskaya A. , Chernyaeva A.
Published: December 2024

The article presents the expert community's assessment of the problem of psychological and pedagogical support for children with learning difficulties in the light of shifting the emphasis from correctional work with children to counselling their parents, as well as the peculiarities and deficits of professional training of specialists who provide such counselling. Based on the results of an empirical study and using a phenomenological approach, the authors present a model of counselling parents of children with learning difficulties. The results of the study are of interest to practitioners (teachers and psychologists), as well as parents raising children with learning difficulties.
Monacolin K in the treatment of hypercholesterolemia - chance or threat?
Authors: Krotowska Katarzyna
Published: December 2024

Introduction
Hypercholesterolemia is a primary element leading to the occurrence of cardiovascular diseases, which are the most common cause of death worldwide. One of the most effective drugs used in the treatment of hypercholesterolemia are statins. Monacolin K is a naturally derived substance that exhibits similar effects.
Materials and methods
The review of studies that follows is based on peer-reviewed scientific publications that may be found on PubMed, Google Scholar and CrossRef. The terms "monacolin K," "hypercholesterolemia," and "monacolin K in the treatment of hypercholesterolemia" were among the most searched.
Results
Review of the literature shows that Monacolin K is a promising substance that exhibits similar effects to statins and like them contributes to improving lipid profile. Unfortunately, fermented wild rice preparations lack clear information on the exact content of Monacolin K. Additionally, it is almost exclusively available in the form of dietary supplements on the Polish market, which have not been subjected to rigorous studies, so their therapeutic effects have not been scientifically proven.
Conclusion
The result of the cited studies indicates that It is necessary to regulate the market of preparations containing fermented wild rice. The package should specify the exact content of the active substance and effectiveness should be confirmed by appropriate studies. It would be promising for preparations to be developed at the level of medication rather than dietary supplements
Vericiguat – possibly next weapon to overcome heart failure. Review of latest literature
Authors: Biskupski Mikolaj , Cygnarowicz Aleksandra , Wojtas Aneta Klaudia , Zabojska Krystyna , Korotko Urszula , Mandziuk Aneta , Witowska Kinga , Turemka Mariola , Hosseinnejad Negar , Sacher Karolina
Published: December 2024

Introduction
Heart failure (HF) is a common clinical syndrome characterized by symptoms such as breathlessness and fatigue, affecting 1-2% of adults in developed countries. Standard treatment for heart failure with reduced ejection fraction (HFrEF) includes a "new quadruple" therapy comprising ARNI/ACE-I, beta-blockers, MRAs, and SGLT2i. However, a subset of patients remains inadequately managed, highlighting the need for new therapies like vericiguat. Vericiguat, an oral soluble guanylate cyclase (sGC) stimulator approved by the FDA in January 2021, shows promise for patients with heart failure with reduced ejection fraction (HFrEF). This review highlights vericiguat's pharmacodynamics, including its mechanism that enhances nitric oxide effects and promotes vasodilation, thereby improving hemodynamic status.
Materials and Methods
This review synthesizes recent literature on vericiguat sourced from PubMed and Cochrane databases, including studies published in English between 2023 and 2024. Eight relevant publications were selected based on strict inclusion criteria.
Results
Reviewed studies demonstrate that vericiguat significantly reduces NT-proBNP levels and lowers the risk of composite cardiovascular death or HF hospitalization. Notably, vericiguat showed efficacy in specific subgroups, including patients with chronic kidney disease and those in NYHA class III/IV.
Conclusion
Vericiguat is a promising candidate for inclusion in the "new quadruple" therapy for HF, particularly for patients with severe symptoms or chronic kidney disease. Further research is essential to clarify its benefits in stable HF patients and its comparative efficacy alongside current guideline-directed medical therapy.
Acute Mountain Sickness: Symptoms, Diagnosis, Risk Factors, Prevention and Treatment
Authors: Śniatała Alicja , Adamowska Agnieszka , Grubski Damian , Nadolny Filip , Bartkowiak Hanna , Jabłoński Jędrzej , Ziarnik Kacper , Kania Martyna
Published: December 2024

Introduction
High mountain climbing has surged in popularity over the past few decades, attracting a diverse range of participants from professional athletes to even recreational enthusiasts, given that this sport has become commercial and more accessible. While high mountain climbing offers numerous mental and physical benefits, it also presents significant risks, among them one of the most dangerous is acute mountain sickness (AMS). Correct techniques of prevention are absolutely vital for the success of the expedition. To be able to read correctly the symptoms is essential for making the right decision during hike and knowing how to act once AMS occurs is necessary to ensure safety for all climbers.
Aim of the study
The purpose of this narrative is to comprehensively describe information about the prevention, symptoms and instructions concerning further procedure while dealing with acute mountain sickness (AMS).
Materials and methods
The methodology of the literature search involved using the keywords “acute mountain sickness” and adding terms such as “prevention”, “symptoms”, “diagnosis”, “risk factors” and “treatment”. The search terms were entered into the PubMed and Google Scholar databases. The review works and clinical trials were taken into account.
Conclusion
Acute mountain climbing occurs above 2500 m. The most important aspects of prevention and treatment is controlled ascent, rapid diagnosis and instant initiation of treatment, meaning descent. The pharmacologic prophylaxis and therapy is not recommended in every case, all of the decisions must be taken individually according to severity of symptoms and general situation in the mountains.
Medial Epicondylitis: A Systematic Review on Causes, Symptoms and Treatment
Authors: Grzelak Alicja
Published: December 2024

Introduction: Medial epicondylitis, often called golfer's elbow, involves pain on the inner side of the elbow. It usually results from repetitive strain on the tendons that connect the forearm muscles to the medial epicondyle. While commonly linked to golfing, it can affect people engaged in various activities requiring repetitive wrist flexion and gripping.
Purpose of work: This paper aims to provide a comprehensive overview of the pathogenesis, imaging characteristics, and treatment strategies for medial epicondylitis.
State of knowledge: Medial epicondylitis can be worsened by activities that require forceful gripping, such as golfing or weightlifting [1][2]. The condition has been extensively studied and is well-documented in the scientific literature. Various treatments are available, including conservative methods like rest, physical therapy, and injections, as well as surgical interventions for persistent cases.
Material and methods: This review draws upon an in-depth analysis of current scientific literature, including recent publications in prominent medical journals and relevant research studies. To identify pertinent scientific publications and research studies, comprehensive searches were conducted on widely recognized academic databases, such as PubMed and Google Scholar.
Summary: Medial epicondylitis, also known as "golfer's elbow," is characterized by pain and tenderness over the bony prominence on the inner side of the elbow. It often results from repetitive strain or overuse of the muscles that flex the wrist and pronate the forearm [3]. Diagnostic imaging, such as X-rays and MRI, can help evaluate this condition [1][4]. Treatment typically involves a combination of conservative approaches, including rest, physical therapy, and anti-inflammatory medications, as well as more invasive options like corticosteroid injections or surgery for persistent cases.
Health Implications of COVID-19 for New Generations: From Physical to Mental Health Challenges
Authors: Grzelak Alicja , Langner Sara
Published: December 2024

Introduction: The COVID-19 pandemic has left a lasting impact on global health, affecting not only physical well-being but also mental and emotional health. New generations face unique challenges, shaped by disrupted lifestyles, prolonged isolation, and evolving healthcare needs. These implications demand a comprehensive understanding of both immediate and long-term health outcomes.
Purpose of Work: This paper explores the multifaceted health impacts of COVID-19 on new generations, emphasizing physical, mental, and social dimensions. By synthesizing current research, the study seeks to highlight key challenges and propose strategies for addressing these health concerns.
State of Knowledge: Emerging evidence reveals a dual burden of physical and mental health issues in younger populations. Long COVID symptoms, reduced physical activity, and developmental delays are prominent physical concerns. Simultaneously, heightened levels of anxiety, depression, and emotional stress reflect the pandemic’s toll on mental health. Socioeconomic disparities further exacerbate these outcomes, while digital reliance during the pandemic has introduced new behavioral patterns requiring attention.
Material and methods: This study utilized a systematic literature review methodology, involving a search across prominent scientific databases like PubMed and Google Scholar, followed by a rigorous screening process to identify relevant studies for in-depth examination.
Summary: COVID-19 has imposed unprecedented health challenges on new generations, blending physical ailments with pervasive mental health struggles. This paper underscores the importance of integrative health approaches and policy-driven interventions to mitigate long-term impacts. Future research must focus on preventive measures, equitable healthcare access, and innovative strategies to foster resilience and holistic recovery.
How Product Display Orientation Affects Customers’ Choice Satisfaction in Online Purchase: A Choice Closure Perspective
Authors: Jia Yanli , Fang Yulin , Ouyang Jun
Published: December 2024

Practice- and Policy-oriented Abstract

Research Spotlights

The current research offers practical guidance for e-commerce websites on effectively displaying products to improve customer satisfaction with their choices and reduce order cancellations, a challenge that has long perplexed online retailers. Specifically, a horizontal (versus vertical) display of comparable products on an e-commerce website is more positively related to customer choice satisfaction by promoting a higher level of choice closure. Our findings suggest that if e-commerce platforms are designing a new interface, they may consider adopting a horizontal display as a beneficial starting point. However, when a vertical design has been adopted for certain reasons, online retailers can incorporate cues of finality (e.g., putting a “the end” mark at the end of a product display) to help customers finalize their choices and achieve choice satisfaction, thereby mitigating potential downsides associated with vertical display layouts.
Safety Assessment of Gender-specific Human Electromagnetic Exposure with Aortic Valve Stents for EV-WPT
Authors: Tan Tianhong , Jiang Tao , Wu Yangyun , Zhu Yu , Chi Yaodan
Published: December 2024

Electric vehicle wireless power transfer brings additional electromagnetic exposure (EME) risks to the human body, especially those with metal implants. This paper focuses on the safety assessment of human EME with aortic valve stents (AVS), and establishes electromagnetic simulation models for different genders of humans, AVS, and electric vehicle-wireless power transfer (EV-WPT) systems. The transmission power of the EV-WPT system is 11 kW. Considering the uncertainty of the EV-WPT system and AVS in practical use, an efficient deep neural network method is proposed to evaluate the EME safety to different genders of humans. Using the standard limits of the International Committee on Non-Ionizing Radiation Protection (ICNIRP) as the judgment standard, comparing human EME under static conditions, it is demonstrated that AVS can change the distribution of induced electric fields in the human body and increase the risk of human EME. Moreover, the probability of male human EME exceeding the standard limits is 22.78% higher than that of female human.