bluuebunny/crossref_metadata_2025 huggingface dataset:
Особенности иммунного ответа на инфекцию Helicobacter pylori у детей с бронхиальной астмой
Authors: Kalichevska M.V.
Published: September 2016

Актуальность. Течение бронхиальной астмы у детей нередко сопровождается заболеваниями желудочно-кишечного тракта (ЖКТ), ассоциированными с Helicobacter pylori (H.pylori)-инфекцией. Наличие H.рylori способствует активации и поддержанию воспалительного процесса с высвобождением цитокинов и медиаторов воспаления и последующими системными эффектами. Цель исследования: изучение особенностей продукции интерферона-γ (IFN-γ) и интерлейкина‑4, -5 и -13 (IL‑4, -5, -13) как маркеров интенсивности аллергического воспаления у детей, больных бронхиальной астмой, инфицированных H.pylori. Материалы и методы. Обследовано 120 детей в возрасте от 6 до 18 лет с бронхиальной астмой. Идентификация H.pylori проводилась дыхательным хелик-тестом (ООО «АМА», Россия). Сывороточные концентрации IFN-γ и IL‑4, -5 и -13 определялись методом иммуноферментного анализа (тест-наборы Diaklone, Франция) до и через 7 дней после окончания лечения патологии ЖКТ. Статистическую обработку проводили с помощью методов вариационной статистики, реализованных в пакете прикладных программ Statistica 6.1. Результаты. У 78 детей с бронхиальной астмой была диагностирована патология ЖКТ, в том числе у 37 человек — ассоциированная с инфекцией H.рylori. Для изучения влияния H.pylori на течение бронхиальной астмы дети были разделены на 3 группы: I группа — 37 детей с бронхиальной астмой и патологией ЖКТ, инфицированных H.pylori, II — 41 Н.pylori-негативный ребенок с бронхиальной астмой и патологией ЖКТ, III — 42 Н.pylori-негативных ребенка с бронхиальной астмой без патологии ЖКТ. Длительность заболевания бронхиальной астмой в I группе составила 7,80 ± 0,17 года, во II — 5,90 ± 0,26 года, в III группе — 3,90 ± 0,48 года (p < 0,05). Наличие Н.рylori-инфекции у детей с бронхиальной астмой сопровождалось более низкими концентрациями IFN-γ по сравнению с детьми II группы (соответственно 8,47 ± 0,14 пг/мл и 9,69 ± 0,32 пг/мл, р < 0,05). Уровень IL‑13 в сыворотке крови был достоверно выше у детей I группы по сравнению с пациентами II группы (8,74 ± 0,22 пг/мл и 7,21 ± 0,35 пг/мл соответственно, р < 0,05). Сывороточные концентрации IL‑4 и -5 были повышены во всех исследуемых группах по сравнению с группой контроля и не зависели от наличия инфекции Н.рylori. После лечения патологии пищеварительного тракта отмечалось улучшение показателей контроля над бронхиальной астмой, которое сопровождалось достоверным снижением концентраций IFN-γ и IL‑13 в I группе детей и IFN-γ и IL‑5 и -13 — во II группе. Вывод. Наличие инфекции H.рylori у детей с гастродуоденальной патологией, протекающей на фоне бронхиальной астмы, сопровождается дисбалансом иммунного ответа, который выражается в снижении выработки IFN-γ, IL‑4 и увеличением IL‑13 по сравнению с Н.рylori-негативными детьми. Лечение патологии ЖКТ сопровождается снижением IFN-γ и исследуемых цитокинов, что клинически способствует улучшению параметров контроля над бронхиальной астмой.
Взаємозв’язки імунологічних та клініко-морфологічних показників у хворих на хронічний гепатит С залежно від наявності змішаної кріоглобулінемії
Authors: Mashko O.P. , Riabokon E.V. , Onischenko T.E. , Furyk E.A.
Published: September 2016

Актуальність. Змішана кріоглобулінемія є найчастішим позапечінковим проявом хронічної HCV-інфекції. Питання ролі цитокінів та особливостей ураження печінки при хронічній HCV-інфекції за наявності змішаної кріоглобулінемії дискусійні. Мета дослідження — визначити взаємозв’язок між змінами імунологічних параметрів (кріоглобуліни, інтерферон γ, інтерлейкін‑4) та клініко-морфологічними показниками хронічного гепатиту С у хворих зі змішаною кріоглобулінемією. Матеріали й методи. Обстежені 82 хворі на хронічний гепатит С. Стадію фіброзу печінки визначали при морфологічному дослідженні гепатобіоптатів. Вміст інтерферону γ та інтерлейкіну‑4 визначали методом імуноферментного аналізу. Вміст кріоглобулінів визначали спектрофотометричним методом. Результати. У хворих зі змішаною кріоглобулінемією виявлено нижчий вміст інтерферону γ та найвищий вміст інтерлейкіну‑4 у сироватці крові, зареєстровано кореляцію між концентрацією кріоглобулінів та вмістом інтерферону γ (r = –0,32; р < 0,05) та інтерлейкіну‑4 (r = 0,36; р < 0,05). Виявлено вищий вміст змішаних кріоглобулінів у хворих зі стадіями фіброзу F3–4 (р < 0,05). Зареєстровано більшу частоту клінічних ознак кріоглобулінемічного синдрому в пацієнтів зі стадіями фіброзу печінки F3–4. Підвищення вмісту змішаних кріоглобулінів асоціюється з появою та кількістю ознак кріоглобулінемічного синдрому (виражена загальна слабкість, шкірна пурпура й синдром Рейно) і вираженістю фіброзу печінки. Підвищення вмісту інтерлейкіну‑4 асоціюється з появою загальної слабкості, шкірної пурпури та тяжким фіброзом печінки. Висновки. Підвищення вмісту змішаних кріоглобулінів асоціюється з появою та кількістю ознак кріоглобулінемічного синдрому та вираженістю фіброзу печінки. Підвищення вмісту інтерлейкіну‑4 корелює з концентрацією кріоглобулінів та асоціюється з клінічними проявами кріоглобулінемічного синдрому та фіброзом печінки F3–4. Для покращення діагностики перебігу хронічного гепатиту С доцільно визначати вміст кріоглобулінів та інтерлейкіну‑4.
Особливості ураження печінки при інфекційному мононуклеозі в дітей
Authors: Sorokman T.V. , Popeliuk O.-​M.V. , Parfionova I.V. , Zymahorova N.O.
Published: September 2016

У даний час спостерігається тенденція до зростання захворюваності на інфекційний мононуклеоз (ІМ). Мета дослідження — виявити клінічні особливості ураження печінки при ІМ у дітей. Матеріали та методи. Проаналізовано дані історій хвороби 42 дітей віком від 4 до 15 років із діагнозом хронічного гепатиту. Визначали активність аланінамінотрансферази, аспартатамінотрансферази, лужної фосфатази, гамма-глутамілтранспептидази, рівень білірубіну, маркери вірусних гепатитів. Проводили ультра­звукове дослідження, імуноферментний аналіз із визначенням у крові маркерів Епштейна — Барр вірусу (ЕБВ) (IgM VCA, IgG EA, IgG VCA, авідність) і цитомегаловірусу (ЦМВ) (IgM, IgG, авідність); ДНК-ЕБВ і ДНК-ЦМВ методом полімеразно-ланцюгової реакції. Виділено 3 групи: 1-ша група — хворі на ІМ ЕБВ-етіології (17 пацієнтів), 2-га група — хворі на ІМ ЦМВ-етіології (16 пацієнтів), 3-тя група — мікст-ІМ ЕБВ + ЦМВ (9 пацієнтів). Дані оброблені методами статистичного аналізу з використанням прикладної програми Statistica 6. Результати. У 85,7 % випадків ІМ перебігав у типовій формі із середнім ступенем тяжкості (збільшення розмірів лімфовузлів у 98,6 % хворих, тонзиліт — у 54,7 %, гепатомегалія — у 71,4 %, спленомегалія — у 38,1 %). Характерні зміни гемограми при ІМ: лейкоцитоз (64,2 %) і атипові мононуклеари (73,5 %). У 15 дітей (35,7 %) підвищені трансамінази. Жовтяничні форми гепатиту спостерігалися в п’яти пацієнтів. Рівень атипових мононуклеарів у крові понад 20 % відзначався в 43,3 % хворих. УЗД виявило дифузне підвищення ехогенності печінки в 36,6 % пацієнтів. Висновки: 1. Гепатит при ІМ виявлений більше ніж у половини хворих, його розвиток і вираженість корелюють з етіологічними особливостями захворювання (мікст-інфекція ЕБВ + ЦМВ, rs = 0,60 ± 0,07); віком (rs = 0,40 ± 0,07), статтю (rs = 0,80 ± 0,07). 2. Гепатит на фоні ІМ характеризується вірогідним переважанням безжовтяничних форм із помірним і короткочасним підвищенням трансаміназ, супроводжується спленомегалією й рівнем атипових мононуклеарів у крові понад 20 %.
Инвагинация кишечника у детей в практике педиатра-инфекциониста
Authors: Usachova O.V. , Silina Ye.A. , Pakholchuk T.N. , Konakova O.V.
Published: September 2016

От умения врача педиатра-инфекциониста правильно интерпретировать абдоминальную боль нередко зависит судьба пациента. В статье анализируется частота развития инвагинации у детей, возникшей на фоне диспептических проявлений, отображены клинические особенности данной хирургической патологии.
Страницы истории: к 100-летнему юбилею Днепропетровской медицинской академии и истокам основания кафедры инфекционных болезней
Authors: Shostakovych-Koretska L.R. , Shevchenko-Makarenko O.P. , Yakunina O.M.
Published: September 2016

История кафедры инфекционных болезней Днепропетровской медицинской академии начинается с 1927 г., когда тогда еще в Днепропетровском медицинском институте (основанном в 1916 г.) на базе городской инфекционной больницы профессором М.Б. Станишевской было начато преподавание инфекционных болезней как отдельной дисциплины. В 1937 г. кафедру инфекционных болезней возглавила ученица М.Б. Станишевской, достойная ее наследница, Е.Г. Попкова. Кандидатскую диссертацию «Об эпидемическом паротите и нейротропности этого вируса» она защитила в 1940 г. В этом монографическом исследовании впервые освещались вопросы паротита как инфекции, которая повреждает не только слюнные железы, но и центральную нерв­ную систему. В 1948 г. на должность заведующего кафедрой инфекционных болезней был избран известный инфекционист, доктор медицинских наук, профессор И.И. Левин. В 1950 г. профессор И.И. Левин одновременно возглавлял кафедру инфекционных болезней и основанную кафедру инфекционных болезней детского возраста. С 1952 г. в Днепропетровском медицинском институте существуют два самостоятельных подразделения: кафедра детских инфекционных болезней под руководством профессора Е.Г. Попковой и кафедра инфекционных болезней под руководством профессора И.И. Левина. В разные годы обе кафедры возглавляли такие выдающиеся ученые, как профессор А.И. Трипольская (1957–1978), профессор В.И. Бычкова (1978–1986), доцент Г.В. Левина (1956–1968), доцент И.В. Штырев (1968–1979), профессор Н.В. Беляева (1979–1994), профессор Л.Р. Шостакович-Корецкая (1994–2008), доцент Н.С. Суременко (1986–2008) и профессор Л.Р. Шостакович-Корецкая (с 2008 г. по настоящее время). Сотрудники кафедры принимают участие в работе съездов и конференций с устными и стендовыми докладами, которые в разные годы проходили в странах СНГ и Европы. В рамках гранта Американского фонда гражданских исследований и развития совместно с американскими коллегами выполнялись фундаментальные исследования по изучению генетических факторов, ответственных за резистентность Т-лимфоцитов к ВИЧ в условиях вертикальной трансмиссии от матери ребенку. Сегодня, празднуя 100-летний юбилей Днепропетровской медицинской академии Министерства здравоохранения Украины, стремясь идти в ногу со временем, помня корифеев медицины и нашей академии, почитая традиции кафедры, не забывая наших ветеранов, мы готовимся достойно встретить 90-летие кафедры инфекционных болезней в 2017 году.
Comportamento e bem-estar de vacas leiteiras submetidas à secagem: Revisão
Authors: Zanin Ediane , Fregonesi Jose Antonio , Mangilli Lívia Galiano
Published: September 2016

Drying of cows carried out about sixty days before the expected date of birthing, is considered of great importance to health, welfare and colostrum and milk production of dairy cattle. Despite it is importance, there is little information in the scientific literature on this procedure, even if it is a common practice on farms. Behavioral changes such as increased frequency vocalizations, reduced feed consumption, prolonged lying and udder apparently swollen during drying period, indicate high levels of stress and can to indicate discomfort and pain. The milking frequency and interval, as well as feed strategies are alternative available to manipulate the milk production and drying of cows. The welfare of farm animals has become a major concern for the society, therefore, drying strategies should be studied. Thus, the objective of this study was to review the importance of an adequate drying management regarding the behavior and welfare of dairy cows.
Balanço socioambiental do munícipio de Novo Brasil/GO no exercício de 2014
Authors: Caetano Graciele Araújo de Oliveira , Oliveira Andressa Rodrigues de , Rabelo Karlla Elizabeth Barros , Paula Marcela Barbosa de , Cintra Denise Gomes Barros , Rey Bruno de Ávila Debom
Published: September 2016

Accountancy is a science that has the purpose to study the qualitative and quantitative variations in the organizations or business entities. Joining this science and environment, there is the environmental resource accounting, which focuses primarily on sustainable development for the stability of economic activities and the damage caused to the environment, thus regulating the environmental assets and liabilities in small and in large companies. Over time, environmental protection has achieved priority in social sector and the business sector, and the society began to demand a new ethical posture. The companies have to account for their actions in order to improve its image by focusing the environmental issue with stakeholders and shareholders, because of constant global change, it was necessary to notice with greater relevance to the environment. The Social Report is a set of information that shows the entity activities, whether public or private, to society, in order to promote its economic and social management, and its relationship with the community, providing as the result its social responsibility. This stability which seeks to achieve economic growth and sustainable development is a tool also called environmental balance. As predicted, some entities haven't become aware of the importance of the existence of a Social and Environmental Balance, thus minimizing the benefits coming from this production. This study aimed to elaborate the Environmental Review of the municipality Novo Brasil - Goiás, in order to demonstrate the financial, social and environmental indicators for the year 2014 as well as the consequences that this information have on the society.
Efeito do estresse sobre a qualidade de produtos de origem animal
Authors: Alves Aldivan Rodrigues , Figueiredo Júnior Jalceyr Pessoa , Santana Marcelo Helder Medeiros , Andrade Maria Verônica Meira de , Lima Joyce Bitencourt Athayde , Pinto Liduína da Silva , Ribeiro Leila de Medeiros
Published: September 2016

World production of animal protein has been growing steadily at the same pace that the demands of consumers for products that meet their needs and desires. So it is of fundamental importance to understanding of the benefits to be achieved with the introduction of programs to minimize the effect of stress on the animal welfare and the final products generated from that holding. The company's payment criterion, yield calculations and carcass quality. Thus, the animal that have a higher quality loss rate due to bruising and injury provided by rudimentary techniques, will provide financial losses to the grower, in addition, the stress can also involve the production and quality of products
Hiperadrenocorticismo em cão: Relato de caso
Authors: Rodrigues Daniel Serafim de Andrade , Barbosa Yago Gabriel da Silva , Silva Nair Chaves Barbosa da , Silva Francisco Lima , Silva Catarina Rafaela Alves da , Sousa João Macedo
Published: September 2016

The hyperadrenocorticism (HAC), or Cushing's disease is a disorder commonly diagnosed endocrine in adults and elderly dogs, characterized by subsequent clinical changes of prolonged exposure to glucocorticoids. This disease has diverse etiologies which can be spontaneous or iatrogenic. The spontaneous hyperadrenocorticism may be associated with the secretion of inappropriate adrenocorticotropic hormone (ACTH) by the pituitary (hyperadrenocorticism pituitary dependent), representing approximately 80% of cases, or an adrenocortical tumor (adrenal Cushing dependent), representing about 15 to 20% of all cases of hyperadrenocorticism. Already iatrogenic HAC is the result of excessive administration of glucocorticoids. The objective was to report the case of a dog, mongrel, of about 15 years, attended at the Veterinary Hospital of the Federal University of Piauí, diagnosed and treated for hyperadrenocorticism.
Efeito de índices técnicos na rentabilidade de propriedades leiteiras participantes do programa “Balde Cheio”
Authors: Lopes Marcos Aurélio , Moraes Flávio de , Bruhn Fábio Raphael Pascoti , Peres Afonso Aurélio de Carvalho , Lima André Luis Ribeiro , Reis Eduardo Mitke Brandão
Published: September 2016

The scope of this research was to analyze the effect of some technical and managerial levels in the profitability of 20 demonstration units (UD) participants of the program "Balde Cheio", in the State of Rio de Janeiro, from January to December in 2011. The profitability analysis considering the gross margin, the net margin, the result (profit or loss), profitability and rentability as indicators of economic efficiency. To describe the profitability indicators, as well as the technical and managerial levels, descriptive statistics was used through the mean, standard deviation, minimum and maximum value, calculated using the statistical software SPSS 18.0. The technical and managerial levels influenced on profitability and rentability in the properties studied. The zootechnical rates percentage of lactating cow, cows in the herd and lactating cows in the herd, animal productivity/ha/year and amount of lactating cows/ha were considered good; However, noted that although gross and net margins are positive, in the long-term producers are in the process of decapitalising, because the result was negative.
Importância da barreira epidérmica na dermatite atópica canina: Revisão
Authors: Villalobos Wendie , Beltrán Laureano Rodríguez
Published: September 2016

Canine Atopic Dermatitis (CAD) is an allergic, chronic and inflammatory skin disease which affects 10-15% of canine population. For several years, pathogenesis of the disease had been linked to hypersensitivity processes mediated by IgE, but during the last decade, researchers have led their efforts to demonstrate the importance of the skin barrier in the development of CAD, based most of the times on previous studies related with Human Atopic Dermatitis. Studies in dog sincluding transepidermal water loss, skin moisture levels and abnormalities in the stratum corneum lipids and in the superficial proteins of the epidermis, filaggrin mainly, have been very important to advance the understanding of this common and frequent disease in veterinary medicine.
Alimentos alternativos para aves e suínos em sistemas de produção com base agroecológica
Authors: Silva Alessandra Aparecida , Tonet Rosa Maira , Pontara Lucimar Peres
Published: September 2016

The animal production in sustainable agrosystems has grown in recent years, mainly by ecological issues, involving the reduction of environmental damage and the greater demand of the final consumer for products free of possible chemical residues. On issues involving food safety, the organic and agroecological production of monogastric is more difficult than that of ruminants due to different feeding of these animals. Ruminants have much of their nutritional requirements met by pastures, while monogastric have much of their nutritional requirements met by diets containing mostly corn and soybean. In most cases, the seeds of these ingredients are transgenic and a large load of agrochemicals is applied for their production. In addition, energy and/or protein sources are insufficient for animal production in sustainable agrosystems. Therefore, alternative sources of foods, which are produced in an unconventional way, without compromising the animal development and that are economically viable, are researched for the use in the feeding of monogastric animals, especially poultry and swine, in sustainable agrosystems. Thus, this work aims to review the main alternative products used for poultry and swine in unconventional production systems.
Association between serum concentration of parathyroid hormone and left ventricle ejection fraction, and markers of heart failure and inflammation in ST elevation myocardial infarction patients treated with primary percutaneous coronary intervention
Authors: Vukotic Snjezana , Ristic Andjelka , Djenic Nemanja , Ratkovic Nenad , Romanovic Radoslav , Vujanic Svetlana , Obradovic Slobodan
Published: September 2016

Background/Aim. Previous studies have shown increased serum concentration of parathyroid hormone (PTH) in acute myocardial infarction and heart failure. In this study we examined the relation-ships between parathyroid hormone status and biochemical markers of myocardial injury and heart failure, as well as electrocardio-graphic (ECG) and echocardiographic indicators of infarction size and heart failure. Methods. In 390 consecutive patients with ST segment elevation myocardial infarction (STEMI), average age 62 ? 12 years, laboratory analysis of serum concentrations of creatine kinase MB isoenzyme (CK-MB), C-reactive protein (CRP) and in-tact PTH and plasma concentration of brain natriuretic peptide (BNP) were done during the first three days after admission. All patients were treated with primary percutaneous coronary intervention (PCI). Exclusion criterion was severe renal insufficiency (glomerular filtration rate ? 30 mL/min). Serum concentration of PTH was measured on the 1st, 2nd and, in some cases, on the 3rd morning after admission and maximum level of PTH was taken for analysis. Patient cohort was divided into four groups according to quartiles of PTH maximum serum concentration (I ? 4.4 pmol/L; II > 4.4 pmol/L and < 6.3 pmol/L; III ? 6.3 pmol/L and < 9.2 pmol/L; IV ? 9.2 pmol/L). Selvester?s ECG score, left ventricle ejection fraction and wall motion index (WMSI) were determined at discharge between 5?14 days after admission. Results. We found that LVEF at discharge significantly decreased (p < 0.001) and WMSI at discharge and ECG Selvester?s score significantly increased across the quartiles of PTH max. level (p < 0.001 for both parameters). BNP, CRP and CK-MB isoenzyme level significantly increased across the quartiles of PTH max. level (p < 0.001; p < 0.001 and p = 0.004, retrospectively). Conclusion. The patients in the 4th quartile of PTH had significantly lower LVEF and higher WMSI and Selvester?s ECG score at discharge. This group of patients also had higher levels of BNP, CRP and CK-MB in blood in the early course of STEMI.
The effects of local endometrial injury by hysteroscopy on in vitro fertilization outcome
Authors: Mitic Dejan , Basic Marin , Petric Aleksandra , Stamenovic Snezana
Published: September 2016

Bacngraund/Aim. Regardless of embryos quality, an appropriate endometrial thickness and a successful embryo transfer (ET), implantation remains a difficulty for a favorable outcome of an in vitro fertilization (IVF). Numerous studies with the aim of increasing implantation rate and pregnancy rate suggest local endometrial injury (LEI) prior to the IVF procedure. Hysteroscopy is a method becoming more widely used both with patients after a failed IVF cycle and with patients before the first IVF, considering the large incidence of uterus cavum pathological states which have a negative impact on the favorable outcome. However, there is still no consensus reached over LEI, the way and time of its performing or its impact. The aim of this research was to determine the effect of hysteroscopically made local endometrial lesion on the IVF procedure outcome, both in the first and in the next IVF cycle and also to examine if the new method of LEI provoking using bipolare electrode has a favorable impact on post IVF pregnancy success. Methods. Total of 81 patients had hysteroscopy performed 30? 50 days prior to IVF, 40 of which had LEI made during hysteroscopy (the LEI group) using bipolar electrode in a way not described in any available literature. Remaning histeroscopically treated patients (n = 41) had no LEI (the non-LEI group). The control group included 151 patient who had IVF performed with no prior hysteroscopy and LEI. Results. The rate of clinical pregnancies after LEI was statistically more significant in comparison to the control group (52.50% vs 34.44%, p < 0.05) and it meant 2.1 time bigger chance to conceive (OR=2.10; 95% CI: 1.04 ? 4.26; p < 0.05). We noticed differences in the implantation rate between the LEI group and the non-LEI group on one side and the control group on the other, in favor of the two groups subjected to hysteroscopy (23.89%, 25.47% vs 18.18%, respectively), but they were not of any statistical significance. Not significantly higher rate of pregnancy was present, after the first and the next IVF, both in the LEI and the non-LEI group when compared to the control one. Conclusion. New method of LEI provoking by bipolar electrode in the process of hysteroscopy is a simple and safe method allowing higher rate of clinical pregnancies and doubling the probabilty of the positive IVF outcome.
Synchronous malignant multicentric cerebral glioma with atypical neuroradiological presentation and comparatively long survival: Case report and literature review
Authors: Peric Predrag , Pavlicevic Goran , Ostojic Jelena , Kostic Dejan , Nikolajevic Sanja , Supic Gordana , Magic Zvonko , Radovinovic-Tasic Sanja
Published: September 2016

Introduction. Synchronous multicentric cerebral gliomas are uncommon brain tumors, mostly malignant, with unknown pathogenesis, unfavorable prognosis and still controversial management. Preoperative differentiation from other multiple brain pathologies by conventional magnetic resonance imaging (MRI) is often difficult, but supplemental use of advanced magnetic resonance techniques should allow the tumor biology to be predicted and an appropriate treatment strategy planned. Case report. We reported a 59-yearold man with double synchronous multicentric cerebral lesions, which had initial MRI and diffusion-weighted imaging presentation as left parietal metastasis and ipsilateral amygdalo- hippocampal low-grade glioma. However, magnetic resonance spectroscopy (MRS) of both lesions showed different metabolite profiles of malignant glioma. En bloc resection of the easily accessible parietal lesion revealed glioblastoma with methylated O6-methylguanine-DNA methyltransferase (MGMT) gene promoter. Subsequently, the patient was treated with temozolomide (TMZ)-based chemoradiation according to Stupp?s protocol, with continuous standard (5/28) adjuvant TMZ in 12 courses. Despite prolonged stabilization of the disease with good life-quality during treatment, the patient died 19 months after diagnosis. The time to tumor progression estimated by MRI was 17 months. Conclusion. MRS significantly improved the differential diagnostic accuracy of conventional MRI in our patient. In accordance with reviewed literature data, the younger age, good initial performance status and methylated MGMT gene promoter were all favorable predictors of longer survival in the reported case. Resection of at least one easily accessible tumor lesion, followed by TMZ-based chemoradiation, with continuous adjuvant TMZ in more than 6 standard courses, seems currently to be the most beneficial therapeutic option for such cases.
Rhinoplasty without nasal packing and splinting
Authors: Vulovic Dejan , Kozarski Jevta , Radivojcevic Uros , Stepic Nenad , Milicevic Sasa , Petrovic Nenad
Published: September 2016

Background/Aim. Most surgeons, at the end of corrective rhinoplasty, use endonasal tamponade and external splinting, primarily because of hemostasis and immobilization. Possible complications of this surgery are various. Pain, nose edema, palpebral swelling and ecchymosis, are the most common and usual. The aim of our study was to evaluate the incidence of nonaesthetic complications and the efficiency of corrective rhinoplasty without the use of tamponade and external splint. Methods. One hundred and fiftyone patients, who underwent primary corrective rhinoplasty without endonasal tamponade and without an external splint, were analyzed at the Clinical Centre ?Kragujevac? in Kragujevac, Serbia, in the period 1999?May 2016. The surgeries were done by the same surgeon. Instead of a splint, sterile skin adhesive tapes were used. Study was prospective, consecutive case-series type. We analyzed the possible complications and subjective estimates of the patients who underwent primary corrective rhinoplasty in described fashion. In assessing postoparative pain, the visual analogue scale (VAS) in a range of 1 to 5 was used. Palpebral swelling and ecchymosis, were estimated 24h after surgery, by the Surgeon Periorbital Rating of Edema and Ecchymosis (SPREE) scale ranging from 0 to 5. The degree of restriction of nasal respiration was evaluated by the scale 1?4. The overall comfort of patients in the postoperative period was evaluated according to a scale: good, no opinion, bad. The patient satisfaction with the aesthetic result was analyzed on 7th and 30th day after surgery, by a scale from 1 (very satisfied) to 5 (very dissatisfied). Results. There were 151 patients aged between 18?47 years. Females were more frequent (72.18%). Most of the patients (40.39%) had moderate pain. None of the patients had neither severe nor the worst pain and 59 patients had no pain at all. Eyelid edema and periorbital ecchymosis were moderate in all patients (100%). The other complications did not occur, apart from one (0.66%) unilateral epistaxis, on postoperative day 10. Most of the patients (52.97%), immediately after surgery, could freely breathe through the nose. The general impression of the patient comfort after surgery was mainly good (74.17%). The majority of patients (52.28%), were satisfied with aesthetic result after 7 days, and 52.32% after 1 month. There were very satisfied patients: on day 7 - 27.15% and on day 30 - 39.73%. Conclusion. We concluded that the rhinoplasty without using tamponade and immobilization was safe, comfortable and economical. The degree of pain, edema and ecchymosis were low, as well as the incidence of other complications.
Independent role of interleukin interleukin-6 and interleukin-8 in the etiology of transfusion reactions to platelet concentrates in children
Authors: Serbic-Nonkovic Olivera , Kuzmanovic Milos , Zivotic Maja , Zunic Svetlana , Jovicic-Gojkov Dragana , Vujic Dragana
Published: September 2016

Background/Aim. Transfusion reaction is an adverse event which manifests during or after administration of blood components to the patient. We aimed to show less known aspects of most common transfusion reactions (allergic and febrile non-hemolytic transfusion reactions ? FNHTR) in the pediatric population at the platelet concentrates. The aim of this study was to determine the role of the accumulated cytokines interleukin-6 (IL-6), interlekin- 8 (IL-8) and presence of anti-platelet antibodies in the etiology of transfusion reaction in children. Methods. The study included 239 pediatric patients, who received platelet concentrates. Data of reported transfusion reaction were collected and evaluated prospectively. The levels of IL-6 and IL-8 were determined using an immunoassay. Antihuman leukocyte antigen antibodies (anti-HLA) and antihuman platelet antigen antibodies (anti-HPA) were identified by Luminex flow cytometry. Results. Toral of 70 transfusion reactions were recorded 52 patients. Allergic reactions occurred in most of the cases (74.3%), followed by FNHTR (17.1%). Platelets derived from buffy coat caused the majority of reactions (73.5%). Patients with infection after platelet transfusion with FNHTR had the highest levels of IL-6, 483.30 ? 1,041.79 pg/mL (p = 0.020). Respectively, the febrile patients had IL-6, 302.52 ? 720.04 pg/mL (p = 0.004). The level of IL-8 in platelet units that caused transfusion reactions was 95.66 ? 319.10 pg/mL, which was significantly higher (p = 0.001) compared to the control platelet units. Conclusion. The predominant etiologic mechanism for FNHTR in our study was leukocyte derived cytokine accumulation during storage. Etiopathogenesis of FNHTR induced by IL-6 and IL- 8 presented differently. We concluded that significant factors in the etiology of FNHTR by IL-6 were the factors related to the pediatric patient (infection, inflammation).
The Miners Who Invented the Alphabet – A Response to Christopher Rollston
Authors: Goldwasser Orly
Published: September 2016

Was the alphabet an invention of elite Northwest Semitic speakers, officials in the Egyptian apparatus “quite capable with the complex Egyptian,” as recently suggested by Christopher Rollston? Or was the alphabet born at the social and cultural fringe? This article reconstructs the possible milieu in which the alphabet was invented: in the mining camps in Sinai, around 1840 B.C.E. by illiterate Canaanite miners who came across the alluring pictorial hieroglyphic script. A paleographic study of the hieroglyphic inscription of Khebeded “(the) brother of (the) ruler of Retenu” on Sinai stela 92, sheds new light on the process of the invention, the possible inventors, and the date of the invention.
Berlin Statue Pedestal Reliefs 21687 and 21688: Ongoing Research
Authors: van der Veen Peter
Published: September 2016

Research report.
Research Report: Thonis-Heracleion, Emporion of Egypt, Recent Discoveries and Research Perspectives: The Shipwrecks
Authors: Fabre David , Goddio Franck
Published: September 2016

The European Institute of Underwater Archaeology’s work on the city of Thonis-Heracleion, which is located in the submerged Canopic region in the west of the Egyptian Nile Delta, has revealed this ancient port-city in all of its detail. From the 8th century BCE, this town was the custom and border post and the emporion that controlled access to the Canopic channel, traded with the Greek regions, and supervised foreign ships. This paper will highlight the discovery of over 60 shipwrecks, dating from the 6th to the 2nd centuries BCE, which demonstrate the intense maritime and fluvial activity in this coastal region. Each shipwreck was radiocarbon dated and a paleobotanical examination of its structural timbers was carried out in order to assess the wood species used in the construction of the vessels. These data constitute an exceptional source of primary evidence to pursue investigations of the development of shipbuilding in the eastern Mediterranean, and of maritime trade and regional connectivity and finally on the interaction between human society/topography of the town and the natural environment.
Accumulations: Updating the Role of Cypriot Bichrome Ware in Egypt
Authors: Hein Irmgard , Stidsing Ragna
Published: September 2016

Cypriot Bichrome Wheel-made Ware is an important index for the study of interrelations in the Ancient Eastern Mediterranean World. The ware is a chronological marker for the beginning of the Late Cypriot Bronze Age and was the subject of a research project during the last decade within the Cyprus project of SCIEM 2000 (FWF, F1412).  The aim of the project was to investigate the appearance of the ware at various sites in the Eastern Mediterranean, and to correlate contexts and finds. This paper presents an overview of the regional distribution of the ware, and a detailed look at its appearance in Egypt. Based on those distributions, we develop ideas about the social role of Bichrome Wheel-made Ware.
Armenian Egyptology Center Research Program 2013
Authors: de Vartavan Christian
Published: September 2016

Research report.
Tell El-Borg, A Frontier Defensive Site and Crossroad to the East
Authors: Hoffmeier James K.
Published: September 2016

Research report.
Some Geographical and Political Aspects to Relations between Egypt and Nubia in C-Group and Kerma Times, ca. 2500–1500 B.C.
Authors: Williams Bruce Beyer
Published: September 2016

New evidence illuminates several problems in the historical geography of Nubia and its political relations with Egypt. At Gebel Uweinat, an inscription naming the country of Yam has changed what we know of the political and cultural geography of the peoples south of Egypt in the late Third Millennium. Regions of Northeastern Africa have been explored, such as the southern Atbai and the Fourth Cataract of the Nile, which is now fairly well known. Connections between these areas and lower Nubia help to understand the development of the archaeological culture known as the Pan Graves. The discovery of a new inscription in Upper Egypt and at Gebel Uweinat have challenged our assumptions about the scale of the Kushite state and its geography in the Second Intermediate Period. The changes are substantial, but they can be integrated with earlier evidence to produce a credible picture of Nubian-Egyptian relations.
Notes on the Mediterranean and Red Sea Ships and Ship Construction from Sahure to Hatshepsut
Authors: Mark Samuel
Published: September 2016

A comparison of depictions of Sahure's Mediterranean and Red Sea ships suggests that the latter were smaller and lighter. Details from these reliefs with a comparison of structural features from the Khufu I vessel suggest that both types of Sahure's ships were designed to be broken down and rebuilt. Moreover, Sahure's small ships may have been designed specifically for the Red Sea, but iconographic, textual, and archaeological evidence allow for the possibility that as early as the Middle Kingdom but no later than the reign of Hatshepsut (c. 1479–1458 BCE) Mediterranean and Punt ships were the same possibly due to changes in ship construction.
Greek Imports Unearthed at the Saite-Persian Cemetery at Abusir
Authors: Smoláriková Květa
Published: September 2016

Although the archaeological excavations of a cluster of shaft tombs in the Late Period necropolis at Abusir are far from being complete, this paper will present in detail recently unearthed Greek imports as evidence for fairly close Graeco-Egyptian relations during the end the Saite Dynasty, i.e. from the middle of the 6th century BCE to the Persian occupation of Egypt in 525 BCE, when commercial contacts were maintained with great enthusiasm by Greek merchants from the coastal areas of Asia Minor.
The Way(S) of Horus in the Saite Period: Tell El-Kedwa and its Key Location Guarding Egypt's Northeastern Frontier
Authors: Hussein Hesham , Alim Elsayed Abdel
Published: September 2016

The “Way(s) of Horus” represented an active route and part of Egypt’s eastern frontier; it is known during the Old, Middle, and New Kingdoms, and continued to be maintained and controlled by Saite kings (Dynasty 26: 664-525 B.C.). Tell el-Kedwa formed part of a series of Saite fortresses guarding Egypt’s East frontier, and lies on the eastern edge of an ancient lagoon, guarding a northern access point to Egypt. In 2007, investigations at Kedwa uncovered a succession of two massive Saite forts, and constitute an important factor in clarifying Tell el-Kedwa’s role as a key control point for access to Egypt during the Late Period. Excavations have continued in 2008 along the south wall of the successive fortresses, and these results will be published in due course. However, the initial excavation results from 2007 have confirmed the role of this fortress as a significant Egyptian garrison defending Egypt’s eastern gateway.
The Sinai Peninsula and its Environs: Our Changing Perceptions of a Pivotal Land Bridge Between Egypt, the Levant, and Arabia
Authors: Mumford Gregory
Published: September 2016

The Sinai Peninsula has provided a continuous land bridge connecting northeast Africa and Asia, and particularly Ancient Egypt with the Levant. This paper focuses mainly upon past through recent explorations of Ancient Egypt’s Prehistoric through pharaonic interactions with the Sinai and its environs, including the Negev, and in particular considers our changing perceptions of Egyptian contact and influence, and also examines Near Eastern, Arabian, and other cross-cultural relations with the Sinai. The nature of these cross-cultural relations fluctuates and changes, taking place in three main areas: the North Sinai transit route between Egypt’s East Delta and Southwest Levant, a Red Sea crossing to South Sinai to obtain turquoise, copper, and other materials, and a more complex, adjacent Negev route between the Red Sea and Southwest Levant, which variously accommodated Egyptians, Canaanites, and others mining copper in the southern Arabah and Faynan, obtaining Red Sea shells, and getting aromatics from Arabia.
A Satellite Survey of El-Markha Plain and Beyond: Searching for Additional Potential Pharaonic Forts
Authors: Parcak Sarah
Published: September 2016

Discoveries from the past 15 years along the Red Sea in Sinai and Egypt have shown just how much remains to be found in an area previously overlooked by many Egyptologists. The excavations and findings at an Old Kingdom fort at Ras Budran and an anchorage and associated complex of sites at Wadi al-Jarf emphasize that there may be additional features to locate. By applying Google Earth Pro to this search, which contains imagery at a resolution of 50 cm, a series of potential additional fort sites have emerged for future assessment. In Sinai and Egypt, however, rapid urban and rural development has made such searches urgent, before these sites are affected by new construction. In the Sinai, which is currently off bounds to most archaeological work, Google Earth Pro provides the best possible tool for conducting surveys prior to the restoration of security and resumption of survey and excavation in this region.
Are the Bearers of the Pan-Grave Archaeological Culture Identical to the Madjay-People in the Egyptian Textual Record?
Authors: Liszka Kate
Published: September 2016

Since 1907, scholars have suggested that the Medjay of the Egyptian textual and artistic record may be equated with the Pan-Grave archaeological culture.  There are various circumstantial reasons for this connection, but typically it has been argued that they were either both mercenaries during the wars of the Second Intermediate Period, or that they originated in the same area in the Eastern Desert.  This article argues against the connection between the Medjay and the Pan-Grave primarily because there is no way to equate these two groups as mercenaries, nor is there reason to believe that the Pan-Grave had any presence in the Eastern Desert.  The author asks scholars to reconsider the archaeological evidence behind these received ideas that were established by ethnic categories in Egyptian texts.
Was the "Minoan Genius" a God? An Essay on Near Eastern Deities and Demons in Aegean Bronze Age Iconography
Authors: Blakolmer Fritz
Published: September 2016

Although the hybrid creature known as the Minoan Genius was clearly derived from the Egyptian Ashaheru / Taweret, according to the iconographical evidence in the Aegean, its functions and meaning differ considerably. Nonetheless, in images showing the Minoan Genius as accompanied by a lion, flanked by lions, dogs or men, or performing actions on a podium-like structure, this fantastic being is clearly defined as a deity. Although a hybrid creature with the position of a deity is highly unusual in Minoan and Mycenaean iconography, we cannot do otherwise than attribute to the Minoan Genius the semi-divine character of a minor deity which is unique in the Aegean Bronze Age. Additionally, seal motifs of the Minoan Genius allow us to pose the question whether Neopalatial Crete was really a coequal member of a ‘Near Eastern koiné’ or whether it was positioned, instead, at the periphery of this ‘ideological realm’.
A Note on an Amenhotep III Plaque from Tel Burna
Authors: Cassuto Deborah R. , Koch Ido , Shai Itzhaq
Published: September 2016

The discovery of a plaque associated to the New Kingdom at Tel Burna in the southern Levant augments archaeological evidence to enhance historical understanding of the Late Bronze Age occupation at the site.
Bringing Egypt to America: George Gliddon and the Panorama of the Nile
Authors: Wolfe S.J.
Published: September 2016

In 19th century America, few people had knowledge of ancient Egypt. George Gliddon’s Panorama of the Nile was the first traveling exhibition that featured lectures and exhibitions of its civilization, its history, its art, and its culture. Although the exhibition was short-lived, it reached a great many people during its tour, inculcating them with its lessons. This article traces the origins and subsequent travels of the Panorama and describes how and where it was exhibited and the events surrounding those exhibitions.
Neither Leisure Class nor Colonialists: Pre-Great War Slovak Travelers in Egypt
Authors: Odler Martin , Hudáková Ľubica
Published: September 2016

Prominent narratives of the 19th century dealing with Egypt were mostly written by members of the colonial powers, but individuals of other nations and nationalities also longed to see Egypt without having any ambitions there. This paper focuses on two travelers, Daniel Šustek (a traveling craftsman) and Ján Roháček (an itinerant Pietist preacher), from the northern Hungarian part of Austria-Hungary, which is now known as Slovak Republic, who visited Egypt in 1871 and 1910, respectively. For each of them Egypt was an exotic, difficult-to-reach destination, and this paper examines their views of Egypt.
The Jewish Diaspora in Ptolemaic and Roman Cyprus: Some Speculations
Authors: Davis Thomas W.
Published: September 2016

The presence of Jews on Cyprus during Ptolemaic and Roman rule, although attested by diverse historical sources, has not been convincingly identified archaeologically. However, the pottery style named Cypriot Sigillata A, may provide oblique evidence of the Jewish Diaspora on Cyprus, or at least its end. This paper will propose a causal relationship between two seemingly unrelated facts: the historically attested destruction of the Jewish Community 115–117 CE during the Diaspora Revolt; and, the sudden disappearance of Cypriot Sigillata A from the archaeological record by 150 CE.
Lamps in Ceramic Assemblages: A Case Study in Late Republican and Early Imperial Central Italy
Authors: Martin Archer
Published: September 2016

The examination of the percentages of functional groups in the composition of ceramic assemblages has been shown to be a useful approach to interpreting a site. This was particularly clear with transport vessels. This study focuses on lamps in central Italy between the late republican and early imperial periods. As the least well represented group, lamps may seem to offer little. Nevertheless, it emerges that there is a normal range of percentages that can be expected for lamps in assemblages of that date range and region, against which unusual results can be evaluated, leading to considerations about the nature of the site where they were found. While series will have to be constructed for other times and places, a brief look at some percentages from 5th-century CE sites from the same region and from a site with a similar date range in Egypt suggests that they will be in the same order of magnitude.
Catullus, Serapis, and Harpocrates
Authors: Skinner Marilyn B.
Published: September 2016

This essay examines three Catullan references to Isiac divinities in the light of controversies over the restoration of Ptolemy XII Auletes to the Egyptian throne and popular struggles to establish sanctuaries of those deities on the Capitoline. It argues for connections between a mention of an eight-bearer litter in c. 10 and the lectica octaphoros belonging to the king, and between an allusion to a shrine of Serapis in the same poem and current religious disturbances. In c. 74, an obscene joke about the child god Harpocrates is linked to conspiracy allegations at the trial of M. Caelius Rufus, but a comparable mention of that deity in c. 102 remains obscure. Catullus’ presentation of his translation of Callimachus’ “Lock of Berenice” as a gift to Q. Hortensius Hortalus might also be tangentially related to the Egyptian Question; certainly the project could have supplied him with a deeper background in Ptolemaic cosmological and religious ideology. Discussion of these references assumes that topical events would be at the forefront of Roman readers’ minds. The essay concludes, however, with speculations on whether the poet’s Bithynian sojourn might have exposed him to alternative perspectives on Isiac cults.
The first World Antibiotic Awareness Week On Antibiotic Resistance
Authors: Yasmeen BH Nazma
Published: September 2016

Abstract not availableNorthern International Medical College Journal Vol.7(2) Jan 2016: 123-124