bluuebunny/crossref_metadata_2025 huggingface dataset:
Análise comparativa da influência do aquecimento e resfriamento na resistência do concreto
Authors: Salomão Pedro Emílio Amador , Colares Rodrigo Silva , Pereira Fabiano Mendes , Oliveira Acly Ney Santiago de
Published: June 2019

A elaboração deste artigo ocorreu após uma pesquisa na qual foi estudada atentamente a análise comparativa da influência do aquecimento e resfriamento na resistência do concreto. Para isso, foram feitos testes em laboratório, além da realização da confecção do concreto em betoneira, onde observou-se que a utilização do traço do material acima mencionado, refere-se à resistência característica da compressão de 25 Mpa. A pesquisa ainda fez um estudo comparativo entre o concreto natural e outro que foi exposto a temperaturas elevadas, em um forno a gás e logo após retirado, submetido a um resfriamento com água, cujo objetivo é analisar o controle e qualificação desse concreto. Conforme dito anteriormente, os ensaios foram todos feitos em laboratório com a finalidade de demonstrar a influência em temperaturas elevadas e em sequência, sua queda instantânea, onde foi executado um traço de concreto, que moldaram 25 corpos de prova dos quais doze foram feitos para comprovar se o traço contém a resistência característica necessária. Como os testes foram efetuados após  sete dias, vinte e um dias e vinte e oito dias, foi observado que em todos eles, o concreto não ganhou resistência, e sim, perdeu grande parte da mesma, chegando a uma redução de 66,74%. Isso chama a atenção para a importância de se ter conhecimento do material e seu comportamento, visto que um incêndio em estruturas como as analisadas, pode acarretar volumosos casos de óbitos e perdas materiais. Sendo assim, é de extrema importância fazer tal avaliação, para evitar possíveis tragédias.
Percepciones sobre la educación ambiental en el Instituto Superior de Educación
Authors: Bezerra Leonardo Mendes
Published: June 2019

El artículo presentado, fruto de una investigación, tuvo como objetivo identificar y describir las acciones y los modos de ver la educación ambiental (EA) en los cursos de licenciatura del Instituto Superior de Educación (ISE), institución vinculada al Centro de Universitario de Anápolis (UniEvangélica). Por tratarse de un estudio de caso, se utilizó el cuestionario como instrumento para recoger datos con los docentes y discentes de los cursos de licenciatura en química, matemáticas, biología, letras, historia y pedagogía de dicha institución. El resultado fue descriptivo y exploratorio en que se discutió cualitativamente bajo la luz de la literatura sobre medio ambiente y EA. Como resultado del estudio, en la visión de los sujetos involucrados que el ISE ha adquirido una mayor percepción de las cuestiones ambientales, a través de las actividades e investigaciones que enfocan las temáticas del medio ambiente y la educación ambiental.
Communication Strategy in Suicide Attempt Preventing Education; Descriptive Study on Instagram Account @intothelightid
Authors: Tampubolon Marissa Ferrari Reminiscere
Published: June 2019

This study focuses on communication strategy used by Into the Light Indonesia in Instagram account @intothelightid to educate the followers dealing with preventing suicide attempt. Afterward, the aim of this study is tried to find out how the communication strategy used by Into the Light Indonesia with the Interpersonal Dynamic concept. The method used is qualitative descriptive. The result of this study shows that the Instagram account @intothelightid used by the user to communicate with the followers in order to bring up intimacy and comfort. In addition, it will make the audience feels to be accepted by others and thus it will ease Into the Light in giving information or educate the users regarding with suicide attempt.
YÜKSEKÖĞRETİMDE NESNELERİN İNTERNETİ İLE İLİŞKİLİ UYGULAMALAR VE YAKLAŞIMLARIN İNCELENMESİ
Authors: FAZLA Sevcan , GEZGİN Deniz Mertkan
Published: June 2019

Nesnelerin interneti (IoT) teknolojisi kavramı, çeşitli
haberleşme protokolleri vasıtasıyla birbirine bağlanıp iletişime geçen, veri
paylaşan elektronik cihazların oluşturdukları akıllı ağ sistemi olarak
tanımlanmaktadır. Özellikle endüstriyel faaliyet gösteren kuruluşlar üretimi ve
verimi arttırmak, zaman ve maliyet açısından kar sağlamak, müşteri
memnuniyetini gerçekleştirmek, karar vermeyi geliştirmek için IoT teknolojisini kullanmaktadır.
Son zamanlarda birçok sektörde kullanımı yaygınlaşan ve sisteme entegre edilen IoT
teknolojisinin yükseköğretimde kullanılması ve oluşabilecek olumlu ve olumsuz
etkileri tartışılmaktadır. Olumlu yönden, yükseköğretimde karşılaşılan eğitim
ve öğretime engel teşkil edebilecek fiziksel lokasyon, ekonomik, coğrafik ve
eğitim dili kaynaklı sorunlara karşı IoT’un çözümler getireceği
düşünülmektedir. Olumsuz olarak ise makineleşmenin diğer sektörlerde olduğu
gibi güvenlik zafiyetleri ortaya çıkaracağı düşünülmektedir. Bu çalışmada, IoT
teknolojisinin yükseköğretimde kullanım amaçları ve geliştirilen uygulamalar incelenmiştir.
Son olarak, inceleme bulguları üzerinden tartışmalar yürütülmüş ve çeşitli
senaryolar ile öneriler sunulmuştur.
Faktor-Faktor Yang Berhubungan Dengan Pemberian ASI Ekskluif Pada Ibu Baduta Di RSIA Budi Kemuliaan Jakarta
Authors: Azhari Anna Sundari , Pristya Terry Y.R.
Published: July 2019

Berdasarkan Profil Kesehatan Indonesia tahun 2017 didapatkan sebesar 46,60% bayi yang mendapatkan ASI eksklusif sampai umur 6 bulan, akan tetapi target pemberian ASI eksklusif secara nasional ialah sebesar 80%. Fasilitas pelayanan kesehatan seperti rumah sakit turut berperan dalam mendukung terwujudnya capaian nasional. Hal ini karena Air Susu Ibu (ASI) eksklusif merupakan makanan yang mengandung nutrisi, hormon, unsur kekebalan pertumbuhan, anti alergi, serta anti inflamasi yang dibutuhkan bagi bayi baru lahir hingga berusia 6 bulan untuk mencukupi seluruh unsur kebutuhan bayi. Tujuan penelitian ialah mengetahui faktor – faktor yang berhubungan dengan pemberian ASI Eksklusif pada ibu Baduta di RSIA Budi Kemuliaan Jakarta. Metode penelitian ialah analitik dengan rancangan cross sectional menggunakan teknik purposive sampling. Subjek penelitian sebanyak 50 responden dengan kriteria ibu yang mempunyai bayi usia 6 – 24 bulan yang merupakan pasien rawat jalan yang berkunjung ke Poliklinik Anak di RSIA Budi Kemuliaan Jakarta. Analisis data dengan menggunakan uji chi-square untuk empat belas variabel independen, dan uji kolmogorov smirnov serta uji regresi logistik untuk satu variabel independen yaitu pengetahuan. Hasil penelitian menunjukan bahwa terdapat hubungan yang bermakna antara informasi laktasi dengan nilai p= 0,010 dan OR= 6,781, kondisi kesehatan bayi dengan nilai p= 0,048 dan OR= 5,167, dan dukungan suami dan keluarga dengan nilai p= 0,040 dan OR= 4,571 dengan pemberian ASI eksklusif. Kesimpulan ialah dari lima belas variabel yang di analisis terdapat tiga variabel yang berhubungan yaitu  informasi laktasi, kondisi kesehatan bayi, dan dukungan suami dan keluarga.
Prinsip Dan Strategi Kesantunan Penulisan Dalam Artikel Ruangan Agenda Bahasa
Authors: Beden Sara
Published: July 2019

Kesantunan penulisan merujuk kepada kehalusan ketika menggunakan bahasa yang melibatkan penggunaan dan pemilihan kata, frasa, ayat dan ungkapan dalam penulisan. Aspek  yang perlu diberi perhatian dalam kesantunan penulisan ialah penggunaan kata panggilan yang betul, pengaplikasian kata sapaan yang betul, gaya bahasa yang indah serta pemilihan kata dan ayat yang sesuai dengan konteks. Sementara topik dan isinya pula tidak menyentuh isu sensitif. Sehubungan itu, kajian ini bertujuan untuk menganalisis strategi kesantunan penulisan dalam artikel Ruangan Agenda Bahasa dalam majalah Dewan Bahasa terbitan Julai 2018. Kajian ini mengaplikasikan tiga model kesantunan, iaitu PS Leech (1983), PK Grice 91975) dan model Asmah Omar (2000). Kajian ini merupakan kajian kualitatif sepenuhnya dengan memberikan fokus kepada analisis teks. Dapatan menunjukkan pengaplikasian ketiga-tiga model  kesantunan, iaitu PS Leech, PK Grice dan kesantunan Asmah Omar yang membentuk pola kombinasi maksim + strategi.  AR1 memperlihatkan pematuhan terhadap maksim Kebijaksanaan + Sokongan + Kualiti + Relevan + Kepatuhan pada Tajuk  + Penjagaan Air Muka manakala AR2 pula mematuhi maksim  Kebijaksanaan + Sokongan + Kualiti + Cara  + Kepatuhan pada Tajuk  + Penjagaan Air Muka. Dapatan ini merefleksikan bahawa kedua-dua penulis dalam ruangan agenda bahasa mematuhi peraturan penulisan dengan tidak mengabaikan aspek kesantunan berbahasa. Kesimpulannya, pematuhan penulis artikel terhadap aspek kesantunan penulisan memanifestasikan penulis dalam bidang akademik tidak meminggirkan inisiatif untuk melestarikan  budaya santun.
Relationship between Work Motivation and Organizational Culture in Enhancing Professional Attitudes of Pakuan University Lecturers
Authors: Suchyadi Yudhie
Published: June 2019

The objectives of this study was to examine the relationship between work motivation, organizational culture toward lecturers professional attitudes. The research was conducted at study program of Pakuan University. The applied research methods are survey method and data analysis technique using the correlation and simple linier regression as well as correlation and multiple linier regression statistical. This research can be classified into correlation research which consist of two independent variables namely work motivation, organizational culture and one dependent variable namely lecturers professional attitudes. This research involved samples of 166 permanent lecturers which were selected by proportional random sampling. Meanwhile, the hypothesis test is conducted on 0.05 significance level. Results emerged that there is a positive relationship between all variables tested in the study. First, there is a positive and significant correlation between the work motivation with the lecturers professional attitudes with regression equation of ?= -1.79 + 1,04X1 and correlation coefficient ry1 = 0.997. The contribution of the work motivation toward the lecturers professional attitudes is 99,7%. Second, there is a positive and significant between correlation the organizational culture with the lecturers professional attitudes with regression equation of ?= -3,06 + 1,02 X2 and correlation coefficient ry2 = 0.997. The contribution of the organizational culture toward the lecturers professional attitudes is 99,7%. Third, there is a positive and significant correlation between the work motivation with organizational culture combined with the lecturers professional attitudes with regression equation of ?= -2,634 + 0,528X1 + 0,505X2 and correlation coefficient ry12 = 0,998. The contribution of the work motivation and organizational culture toward the lecturers professional attitudes is 99,8%. Based on the results above it can be concluded that the lecturers professional attitudes can be improved through a high working motivation and the organizational culture
Student Mental Effort on Integrated Science Curriculum Content Analysis and Pedagogy
Authors: Permana I. , Firman H. , Redjeki S. , Hamidah I. , Safitri N.
Published: June 2019

This study aims to determine the profile and outlook of prospective elementary school teachers on mental effort on Integrated Science curriculum materials integrated content and pedagogy as well as to know the pattern of integrated IPA curriculum analysis integrated content and pedagogy. The subjects of the research are prospective teachers of elementary school one of the universities in the city of Bogor semester 5 class of 2016/2017 as many as 31 students. The data needed to answer the problem of qualitative data. The data were collected with several techniques such as observation and questionnaires. The main questions asked in this study are the questions asked to prospective elementary school teachers. Principal questions asked to prospective teachers of elementary school, the question to reveal the mental business of prospective elementary school teachers in the curriculum analysis courses. Based on the results of research, applied lecture strategy resulted in low mental effort. In the curriculum analysis lectures found increased mental effort caused by material complexity.Keywords: mental effort, integrated science, integrated content and pedagogy lectures, curriculum analysis
A Role Of Emotional Intelligence Improving Lecturer Performance
Authors: Harni Budi
Published: June 2019

The objective of this study is to examine a role of emotional intelligence in improving lecturer performance. This study used a quantitative approach which surveyed 107 part-time of lecturers selected by a proportional random sampling of 3 (three) high school economics in Bogor. The result conveyed that there is positive and significant role of emotional intelligence in improving lecturer performance. It is shown that there is a positive significant between emotional intelligence with lecturers performance with coefficient correlation ry=0,632 and coefficient determination ry=0,400 (40%) with the regression equation ?=27,86+0,8X1, Another factor that effects the variable lecturers of 60 %.
Relationship Between Organizational Culture and Work Satisfaction With Commitment to Organization
Authors: . Herman
Published: June 2019

The purpose of this study is to determine the existence of a relationship between organizational culture and job satisfaction with the commitment to the organization (Studies On Employees Tous Les Jours Bakery).Population in this research is total employee of Tous Les Jours Bakery counted 364 people, while that will be used as sample of research is 200 employee of Kitchen Staff . Based on Slovin formula 133 people are taken as samples. The research instrument is questionnaire. The obtained data is then processed by using correlation analysis techniques with the assistance of SPSS (Statistical Package for Social Science) software. The results showed that: First, the organizational culture on organizational commitment has a significant relationship and has a contribution of 11.3%. Second, job satisfaction and commitment to the organization has a very significant relationship and has a contribution of 21.7%. Eventually, both organizational culture and job satisfaction simultaneusly have a very significant relationship and have contributed 25.7%, the remaining 74.3% is determined by other unexamined variables
EFFECTIVENESS OF THE USE OF LEARNING MODEL CONTROVERSIAL ISSUES (CI) ON CRITICAL THINKING ABILITY
Authors: Cahyo Edo Dwi , Kodariyati Laila
Published: June 2019

This research is motivated by the low ability of students to think critically. The purpose of the study was to determine the effect of the Controversial Issues (CI) learning model in improving students' critical thinking skills. This study uses a quantitative approach with a quasi-experimental method. The study design used Nonequivalent [Pre-Test and Post-Test] Control Groups Design (NCGD). The research samples were fourth grade students of SDN 4 Metro Timur, SDN 5 Metro Timur, SDN 8 Metro Timur, and SDN 10 Metro Timur, 60 students were used as the experimental class and 60 students were used as the control class. Data collection tools in the form of sheets about students' critical thinking skills. Data collection techniques in the form of tests, namely pretest to measure the initial ability of students' critical thinking skills and posttest to see the final ability. Based on the results of the study concluded that the effectiveness of the use of the Controversial Issues learning model affects the critical thinking skills of class IV elementary school students, so that students' critical thinking skills in the experimental class are much better when compared to the control class that has conventional learning. Keywords: Controversial Issues, learning model, Social Skills.
IMPLEMENTATION OF THE MIND MAPPING MODEL WITH SCATTERGORIES GAME IN IMPROVING CREATIVITY AND LEARNING OUTCOMES IN NATIONAL EDUCATION MATERIALS
Authors: Pudjiastuti Sri Rahayu
Published: June 2019

This study aims to find the Application of the Mind Mapping Model with Game Scatterories in Improving Student Creativity and Learning Outcomes in the Indonesian Legislation Regulations Material in class VI of MI Nurul Huda Cimanggis Depok. The results obtained were the Application of the Mind Mapping Model with Game Scattergories, the first cycle by obtaining an average score of 69.22, in the second cycle a score of 74.18 was obtained and in the third cycle the Application of the Mind Mapping Model with Game Scattergories managed to score 77 , 90 points and succeeded in increasing the Learning Outcomes variable in National Legislation Materials and Creativity in achieving student completeness. The conclusion of the study is the Application of the Mind Mapping Model with Game Scatterories has succeeded in improving Learning Outcomes in the Material of National Legislation Regulations and Creativity of Grade VI MI Nurul Huda Cimanggis Depok. The implication of the research is to make the results of research as a reference in developing students' creativity and the concept of national legislation can be used as a guide for behavior in life in families, schools and communities. Suggestions are intended for students, teachers, principals, governments, institutions and students so that the results of this study can be a reference in the development of learning models.
STUDENT ARGUMENTATION SKILL ANALYSIS OF SOCIOSCIENTIFIC ISSUES IN SOLVING ENVIRONMENTAL PROBLEMS
Authors: Istiana Rita , Herawatia Desti
Published: June 2019

This is a mixed method-explanatory research. This study aims to obtain information about the relationship between the ability to solve environmental problems with students 'argumentation skills about socio-scientific issues and the reasons why the variable ability to solve environmental problems has a very high relationship in improving students' argumentation skills about socio-scientific issues as well as other factors that influence it in addition to the ability to solve environmental issues. This research was conducted in November 2017 until May 2018. The population of this research is Biology Education Student, FKIP, Universitas Pakuan academic year 2017/2018. Sampling technique using purposive sampling and Slovin. The sample of 113 students consist of semesters 2 to semester 6. Based on the result of significance test and linearity test it can be concluded that simple regression analysis with equation Ŷ = 0,898 + 0,049 X is significant and linear. Based on the results of quantitative research obtained correlation coefficient (ry) between the ability to solve environmental problems with student argumentation skills about socio-scientific issues of 0.765. The value of this correlation coefficient shows that the null hypothesis (H0) is rejected and the alternative hypothesis (Ha) is accepted, it means that the ability to solve the environmental problems contributes very highly to students' argumentation skill about socio-scientific issue. Based on the results of interviews on several sources, there are other factors that influence students' argumentation skill about socio-scientific issues among others, confidence, lecturer role, and peer role during discussion.
Estudio longitudinal: Cáncer de Ovario en el Instituto Nacional de Oncología y Radiobiología de Cuba (INOR), resultados del tratamiento.
Authors: García Alonso Iván , Linchenat Lambert Alejandro , Pérez Martínez Roberto , Silveira Pablos Mario , Esperón Noa Roberto , Aguilar Vela de Oro Kenia
Published: July 2019

Introducción: El cáncer de ovario es una causa común de muerte entre las mujeres que desarrollan neoplasias ginecológicas. La supervivencia depende de factores clínicos y del tipo de cirugía. El objetivo del presente estudio es describir la supervivencia de un grupo de pacientes con diagnóstico de cáncer de ovario tomando en cuenta varios factores.

Métodos: El presente estudio longitudinal retrospectivo se realizó en mujeres con cáncer de ovario tratadas en el Instituto Nacional de Oncología y Radiobiología, La Habana-Cuba entre el 1 de enero y el 31 de diciembre de 2005, con seguimiento de por lo menos 5 años. Las variables fueron edad, tipo histológico del tumor, etapa clínica de la FIGO, grado de diferenciación celular, valores del biomarcador CA-125, tipo de cirugía realizada, respuesta a la quimioterapia utilizada, supervivencia, recurrencias. El paquete estadístico utilizado fue SPSS 11.0 para Windows. Se aplicaron pruebas estadísticas como la prueba no paramétrica de Kruskal-Wallis, la prueba no paramétrica de MannWhitney y la prueba de Chi-cuadrado de Pearson.

Resultados: Se registraron 29 casos de mujeres con cáncer de ovario. Once casos (37.9 %) fueron en menores de 45 años. En Etapa clínica III, 18 casos (62.1 %). De grado indiferenciado en 17 casos (58.6 %). 16 casos (55.2 %) fueron del tipo histológico seroso. El valor del CA-125 fue >35 U/mL en 13 casos (61.9 %). Las mujeres con etapa clínica I, tuvieron un Intervalo Libre de la Enfermedad (ILE) de 46 meses versus 27 meses en mujeres con etapa III y 12 meses en etapa IV (P>0.05). El grado de diferenciación celular Bien diferenciado determinó estadísticamente el mejor ILE: 55 meses versus 27 meses en el grado moderadamente diferenciado y de 21 meses en el grado indiferenciado (P=0.025). El tipo histológico así como los niveles de CA-125 no determinaron diferencias estadísticas de ILE, así como en Supervivencia Global Media (SGM). Según el tipo de tratamiento no existieron diferencias estadísticas significativas en el ILE, SGM. Sin embargo las cirugías clasificadas como “óptimas” por parte del equipo quirúrgico tuvieron mayor ILE (Delta 17 meses) P=0.038.

Conclusión: En esta serie de casos presentada, las pacientes con cáncer de ovario en Etapa clínica I tuvieron una mejor supervivencia que las pacientes con Etapa clínica III. Así mismo las cirugías clasificadas como óptimas tuvieron mayor intervalo libre enfermedad y mayor supervivencia libre de enfermedad.
Predictores de Mortalidad en Infecciones de Pacientes Neutropénicos Febriles Críticos.
Authors: Marín Karina , Caballero Henry , Unigarro Luis , Del Pozo Gustavo , Montero Nadia , Simancas Racines Daniel
Published: July 2019

Introducción: La mortalidad relacionada a la neutropenia febril puede ser muy alta en ciertas poblaciones de alto riesgo. El objetivo del presente estudio fue identificar factores predictores tempranos de mortalidad en una cohorte de pacientes oncológicos con neutropenia febril admitidosen una unidad de cuidados intensivos (UCI).

Métodos: Estudio observacional retrospectivo en pacientes con neutropenia febril mayores de 18 años ingresados en la UCI del Hospital Oncológico Solón Espinosa Ayala de Quito. Se recogieron variables sociodemográficas, clínicas, de laboratorio y microbiológicas de los registros clínicos al ingreso. Con dichas variables se construyeron modelos predictivos de mortalidad mediante análisis de regresión logística para identificar predictores de muerte.

Resultados: Se registraron 107 pacientes con episodios de neutropenia febril, el 53.3 % de los casos presentaron neutropenia severa y en un 29.9 % de los casos la neutropenia duró más de 10 días. La prevalencia de bacteriemia fue del 34.6 %. El 34.6 % de los pacientes murieron (n=37), de estos el 22.4 % falleció en la UCI. Edad superior de 40 años, valores de procalcitonina superiores a 4 ng/ml, puntuaciones altas en APACHE II y la necesidad de apoyo ventilatorio se asociaron con mayor riesgo de muerte en el modelo multivariado; el valor predictivo en la validación interna tuvo una precisión de 81.3 %; sensibilidad de 63.6 %; especificidad de 90.5 %; valor predictivo positivo de 77.8 %; valor predictivo negativo de 82.6 %; área bajo la curva de 0.87.

Conclusión: Factores como la edad mayor de 40 años, procalcitonina > 4 ug/ml al ingreso, valores de APACHE II y necesidad de ventilación mecánica están asociados con mayor riesgo de muerte.
Tumor Mucinoso Papilar Intra Ductal del Páncreas
Authors: Nieto Orellana Iván , Hernández Ludueña Lucia , Paladines Ernesto , Carpio Guerrero Arturo Fernando
Published: July 2019

Introducción: La aparición de nuevas técnicas de imagen y mayor conocimiento de esta entidad han contribuido para que el diagnóstico del Tumor Mucinoso Papilar Intraductal haya aumentado en la última década. En el presente artículo describimos un caso de un paciente con Tumor Mucinoso Papilar Intraductal de páncreas, hallazgo incidental en Tomografía computarizada de abdomen.

Caso Clínico: Se trata de una mujer de 71 años de edad, con antecedentes de Diabetes tipo 2, Hipertensión Arterial Esencial, y cáncer de mama intervenida. En un estudio de control con tomografía computarizada de abdomen se observó un tumor pancreático de 3 x 1.1 cm. Se realizó una punción transagástrica, con lo que se obtuvo una muestra para estudio patológico, el cual reportó una neoplasia mucinosa papilar intraductal.

Evolución: La paciente fue sometida a cirugía con la Técnica de Whipple, con duodenopancreatectomía, en donde se retiró la cabeza del páncreas con el tumor adyacente. El estudio de patología confirmó una neoplasia mucinosa papilar intraductal. La paciente no presentó complicaciones post-operatorias y continúa en revisión en consulta externa.

Conclusión: Por tratarse de una lesión maligna, el diagnóstico oportuno y correcto fue importante en este caso, para la conducta terapéutica quirúrgica resolutiva.
Caso Clínico: Cáncer de Tiroides de Etiología Sarcoma en Pediatría
Authors: Leone Pignataro Mario , Zambrano García Cecilio
Published: July 2019

Introducción: El cáncer de tiroides es de presentación poco frecuente en pacientes pediátricos, que en lo general dependiendo del tipo celular tiene una evolución favorable posterior a cirugía e iodoradioablacion. En el Instituto Oncológico Nacional se registró una incidencia de 11 casos en menores de 15 años entre el 2010 y 2016.

Caso Clínico: se presenta el caso de un hombre de 13 años con diagnóstico de sarcoma de tiroides de tipo cartilaginoso, con marcador tumoral KI67 positivo, de presentación agresiva e invasión ganglionar regional y metástasis, con presentación inicial de lesión tumoral de gran volumen en región tiroidea, acompañada de disnea y disfagia.

Evolución: El plan quirúrgico oncológico fue citorreducción, seguido de un esquema de quimioterapia y radioterapia con el objetivo de aumentar su expectativa de vida.

Conclusión: Los sarcomas son tumores poco frecuentes, representando menos del 1% de todas las neoplasias. Se presenta este caso, porque existen pocos reportes a nivel mundial.
Medicina y Cirugía sin Sangre
Authors: Frías Toral Evelyn , Panchana Eguez Guido , Marengo Baquerizo Carlos , Leone Pignataro Mario , Chong Loor Cesar , Armijos Vélez Jorge , De La Torre Terranova Olivia , Plaza Rubio Julio , Sánchez Hilbron Alberto , García Cruz Carlos , Posligua León Katty , Espin Custodio Luis , Tanca Campozano Juan , Zambrano Cecilio , Panchana Coello Guido
Published: July 2019

Introducción: Los riesgos asociados con las Transfusiones de Sangre Alogénicas (TSA) son ampliamente conocidos y han contribuido a nuevos paradigmas de tratamiento para la medicina y cirugía sin sangre. Por tanto, es importante contar con estrategias terapéuticas efectivas y prácticas que sirvan como alternativas al uso de TSA. Este informe describirá las estrategias aplicadas a los pacientes de este reporte.

Métodos: Estudio retrospectivo descriptivo de alternativas a la TSA utilizadas en SOLCA Guayaquil con pacientes que no aceptaron TSA bajo ninguna circunstancia, entre los años 2011 y 2017. La estrategia terapéutica se basó en un diagnóstico temprano y un tratamiento agresivo de la anemia y cualquier tipo de sangrado activo. Se utilizó eritropoyetina, hierro y folato, según requerimientos del paciente. Todos los pacientes quirúrgicos recibieron ácido tranexámico y otros hemostáticos tópicos según necesidad.

Resultados: De 73 pacientes oncológicos, el 68.5 % eran no quirúrgicos, de este grupo el 62 % recibió quimioterapia. La hemoglobina aumentó hasta 12.6 g/dL. Por tratamiento global por paciente se administraron hasta 3000 mg de hierro, 140.000 unds de eritropoyetina y megadosis de vitamina C fue aplicada con una media de 24 gramos. Todos los pacientes aumentaron sus niveles de hemoglobina en un promedio de 25 días.

Conclusión: Es esencial iniciar un tratamiento temprano, preventivo y coordinado con un equipo multidisciplinario comprometido a estos esquemas. Los pacientes respondieron bien a los medicamentos y las dosis recibidas y no se informaron efectos secundarios. También podemos ver que estas estrategias son efectivas y factibles de aplicar.
Mortalidad de Pacientes Oncológicos vinculados a Neutropenia
Authors: García Cruz Carlos , Vivar Maldonado Josefina , Frías Toral Evelyn , Zambrano García Cecilio
Published: July 2019

Introducción: La neutropenia absoluta se presenta comúnmente en pacientes oncológicos en tratamiento activo de quimioterapia, lo que determina aumento de morbi-mortalidad y en muchos casos el manejo clínico debe realizarse en una Unidad de Cuidados Intensivos (UCI). El objetivo del estudio es reportar la mortalidad y supervivencia de un grupo de pacientes neutropénicos ingresados en una UCI.

Métodos: En el área de UCI del Instituto Oncológico Nacional “Dr. Juan Tanca Marengo”, Solca-Guayaquil, se realizó una investigación observacional retrospectiva, del período Enero 2015 a diciembre 2016. Se seleccionaron pacientes mayores de 18 años con recuentos de neutrófilos ?500 células / mm3. Las variables fueron sexo, tipo de cáncer, diagnóstico de ingreso, SOFA, ventilación mecánica, falla Hepática, falla renal, tipo de Diagnóstico Infeccioso, tipos de muestras recabadas de cultivos con resultados positivos, germen aislado y mortalidad.Se utiliza análisis descriptivo, de supervivencia, Regresión de COX y análisis de Kaplan Meier.

Resultados: Ingresaron al estudio 99 casos, 50 mujeres (51 %), la edad media de 33.7 ±24 años. Los diagnósticos oncológicos más prevalentes fueron Leucemia Linfoblástica Aguda 39 casos (39.4 %) y Leucemia Mieloide Aguda 11 casos (11.1 %). La mortalidad fue de 58 casos (58.6 %) con una supervivencia de 19.7 ± 4.8 días. La Regresión de COX (OR) para hombres fue de 0.7 (IC 95 0.43 – 1.246) P= 0.25. La supervivencia por edad fue mayor en el grupo de 10 a 29 años (37.4± 19.8 días), en el grupo de 50 a 59 años, fue de 4.2 ±1.1 días (P<0.05). No existieron diferencias estadísticas de la supervivencia según el motivo de internación.

Conclusión: En el presente estudio la mortalidad reportada en pacientes con  neutropenia ingresados a UCI fue del (58.6 %). La supervivencia no está asociada al sexo y la mejor supervivencia está asociada con la menor edad. No existieron diferencias estadísticas de la supervivencia según el motivo de internación.
Hubungan Umur dan Konsumsi Makanan Mengandung Zat Besi Dengan Anemia Pada Ibu Hamil Di Puskesmas Talise Palu
Authors: Elviyaningsih Susan , Rafika Rafika , Candriasih Putu
Published: July 2019

Anemia in pregnant women is called a potential that endangers the mother and child, therefore anemia requires serious attention from parties involved in health services. The purpose of this study is to know the relationship of age and consumption of iron-containing foods with the incidence of anemia in pregnant women in Talise Palu Health Center in 2017. The type of research is descriptive comparative using a cross sectional approach. The population of all pregnant women in the Talise Health Center area. The sample in this study amounted to 55 respondents with the sampling technique using consecutive sampling technique. The data collection is done through direct interviews and direct Hb measurements. Data analysis using univariate frequency distribution and bivariate analysis with Fisher's Exact Test. The results of the study of 55 respondents there were 96.4% of pregnant women who had anemia, with the age of pregnant women not at risk of 85.5% and pregnant women who rarely consumed foods containing iron there were 78.2%. The results of statistical tests using Fisher's Exact Test showed that there was a relationship between consumption of iron-containing foods (p = 0.04) with the incidence of anemia in pregnant women at Talise Palu Health Center in 2017 and no age relationship (p = 0.728) with anemia in pregnant women . Conclusion that age has no relationship with the incidence of anemia in pregnant women. Consumption of iron-containing foods is associated with the incidence of anemia in pregnant women. Suggestions for midwives who work at the KIA-KB Poli to continue to provide services according to operational standards during pregnancy examinations so that anemia in pregnant women can be treated and even prevented during pregnancy.Keywords: Pregnant, Anemia, consumption of foods containing iron
Aiding Dictionary Learning Through Multi-Parametric Sparse Representation
Authors: Stoican Florin , Irofti Paul
Published: June 2019

The ℓ 1 relaxations of the sparse and cosparse representation problems which appear in the dictionary learning procedure are usually solved repeatedly (varying only the parameter vector), thus making them well-suited to a multi-parametric interpretation. The associated constrained optimization problems differ only through an affine term from one iteration to the next (i.e., the problem’s structure remains the same while only the current vector, which is to be (co)sparsely represented, changes). We exploit this fact by providing an explicit, piecewise affine with a polyhedral support, representation of the solution. Consequently, at runtime, the optimal solution (the (co)sparse representation) is obtained through a simple enumeration throughout the non-overlapping regions of the polyhedral partition and the application of an affine law. We show that, for a suitably large number of parameter instances, the explicit approach outperforms the classical implementation.
Multi-Omics Analysis Reveals Up-Regulation of APR Signaling, LXR/RXR and FXR/RXR Activation Pathways in Holstein Dairy Cows Exposed to High-Altitude Hypoxia
Authors: Kong Zhiwei , Zhou Chuanshe , Chen Liang , Ren Ao , Zhang Dongjie , Basang Zhuzha , Tan Zhiliang , Kang Jinhe , Li Bin
Published: July 2019

Changes in the environment such as high-altitude hypoxia (HAH) high-altitude hypoxia can lead to adaptive changes in the blood system of mammals. However, there is limited information about the adaptation of Holstein dairy cows introduced to high-altitude areas. This study used 12 multiparous Holstein dairy cows (600 ± 55 kg, average three years old) exposed to HAH conditions in Nyingchi of Tibet (altitude 3000 m) and HAH-free conditions in Shenyang (altitude 50 m). The miRNA microarray analysis and iTRAQ proteomics approach (accepted as more suitable for accurate and comprehensive prediction of miRNA targets) were applied to explore the differences in the plasma proteomic and miRNA profiles in Holstein dairy cows. A total of 70 differential miRNAs (54 up-regulated, Fold change (FC) FC > 2, and 16 down-regulated, FC < 0.5) and 226 differential proteins (132 up-regulated, FC > 1.2, and 94 down-regulated, FC < 0.8) were found in the HAH-stressed group compared with the HAH-free group. Integrative analysis of proteomic and miRNA profiles demonstrated the biological processes associated with differential proteins were the immune response, complement activation, protein activation, and lipid transport. The integrative analysis of canonical pathways were most prominently associated with the APR signaling (z = 1.604), and LXR/RXR activation (z = 0.365), and FXR/RXR activation (z = 0.446) pathways. The current results indicated that Holstein dairy cows exposed to HAH could adapt to high-altitude hypoxia by up-regulating the APR, activating the LXR/RXR and FXE/RXR pathways.
A Model-Based Approach of Foreground Region of Interest Detection for Video Codecs
Authors: Zhang Zhewei , Jing Tao , Ding Bowen , Gao Meilin , Li Xuejing
Published: July 2019

Detecting the Region of Interest (ROI) for video clips is a significant and useful technique both in video codecs and surveillance/monitor systems. In this paper, a new model-based detection method is designed which suits video compression codecs by proposing two models: an “inter” and “intra” model. The “inter” model exploits the motion information represented as blocks by global motion compensation approaches while the “intra” model extracts the objects details through objects filtering and image segmentation procedures. Finally, the detection results are formed through a new clustering with fine-tune approach from the “intra” model assisted with the “inter” model. Experimental results show that the proposed method fits well for real-time video codecs and it achieves a good performance both on detection precision and on computing time. In addition, the proposed method is versatile for a wide range of surveillance videos with different characteristics.
Radiosonde-Observed Vertical Profiles and Increasing Trends of Temperature and Humidity during 2005–2018 at the South Pole
Authors: Xu Min , Li Yubin , Yang Qinghua , Gao Andrew E. , Han Bo , Yang Yuanjian , Yu Lejiang , Wang Linlin
Published: July 2019

The vertical profiles and trends of temperature and humidity at the South Pole up to 10 km above mean sea level (amsl) were investigated by using radiosonde data collected from March 2005 to February 2018. During an average year between 2005 and 2018, the highest (lowest) temperature in the lower troposphere was approximately −25 °C (−60 °C) in December (July) at a height of about 500 m above the surface (at the surface). A temperature inversion layer above the surface was found during the whole year but was weaker during the summer, while the inversion layers at the tropopause (about 8 km amsl) mostly disappeared during spring and winter. General warming trends were found at all heights and months, but in a few heights and months cooling trends still occurred (e.g., in September below 7 km amsl). Nevertheless, seasonal and yearly averaged temperatures all presented warming trends: 1.1, 1.3, 0.6, 1.5 and 1.1 °C/decade at the surface, and 0.7, 1.0, 0.3, 0.3 and 0.6 °C/decade for the layer average from the surface to 10 km amsl, for spring, summer, autumn, winter, and yearly average, respectively. Most of the water vapor was confined in the lowermost 3 km of the atmosphere with a maximum of 0.35 g kg−1 in December at a 200 m height above surface, and the specific humidity had the similar characteristic of annual cycle and inversion layers as the temperature. At heights below 5 km amsl, increasing trends of specific humidity larger than 0.02 g kg−1/decade occurred during summer months, including the late spring and early autumn, and the annual mean showed an increasing trend of about 0.01–0.02 g kg−1/decade. Meanwhile, above 5 km amsl, the trends became small and generally less than 0.02 g kg−1/decade in all the months, and beyond 7 km amsl the specific humidity remained almost invariant due to its small moisture content as compared with lower levels. From the surface to 10 km amsl, the specific humidity averaged trends of 0.0062, 0.019, 0.0013, 0.002 and 0.007 g kg−1/decade for spring, summer, autumn, winter and yearly average, respectively.
Aerosolization of Nanotherapeutics as a Newly Emerging Treatment Regimen for Peritoneal Carcinomatosis
Authors: Shariati Molood , Willaert Wouter , Ceelen Wim , De Smedt Stefaan C. , Remaut Katrien
Published: June 2019

Recent advances in locoregional chemotherapy have opened the door to new approaches for the clinical management of peritoneal carcinomatosis (PC) by facilitating the delivery of anti-neoplastic agents directly to the tumor site, while mitigating adverse effects typically associated with systemic administration. In particular, an innovative intra-abdominal chemotherapeutic approach, known as Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC), was recently introduced to the intraperitoneal (IP) therapy regimens as a palliative therapeutic option in patients with PC, presumably providing a better drug distribution pattern together with deeper drug penetration into tumor nodules within the peritoneal space. Furthermore, the progress of nanotechnology in the past few decades has prompted the application of different nanomaterials in IP cancer therapy, offering new possibilities in this field ranging from an extended retention time to sustained drug release in the peritoneal cavity. This review highlights the progress, challenges, and opportunities in utilizing cancer nanotherapeutics for locoregional drug delivery, with a special emphasis on the aerosolization approach for intraperitoneal therapies.
Wnt-11 as a Potential Prognostic Biomarker and Therapeutic Target in Colorectal Cancer
Authors: Gorroño-Etxebarria Irantzu , Aguirre Urko , Sanchez Saray , González Nerea , Escobar Antonio , Zabalza Ignacio , Quintana José Maria , Vivanco Maria dM , Waxman Jonathan , Kypta Robert M.
Published: June 2019

The expression of the secreted factor Wnt-11 is elevated in several types of cancer, including colorectal cancer, where it promotes cancer cell migration and invasion. Analysis of colorectal cancer gene expression databases associated WNT11 mRNA expression with increased likelihood of metastasis in a subset of patients. WNT11 expression was correlated with the expression of the Wnt receptors FZD6, RYK, and PTK7, and the combined expression of WNT11, FZD6 and RYK or PTK7 was associated with an increased risk of 5-year mortality rates. Immunohistochemical analysis of Wnt-11 in a cohort of 357 colorectal cancer patients found significantly higher Wnt-11 levels in tumors, compared with benign tissue. Elevated Wnt-11 levels occurred more frequently in rectal tumors than in colonic tumors and in tumors from women than men. In univariate analysis, increased Wnt-11 expression was also associated with tumor invasion and increased 5-year mortality. High Wnt-11 levels were not associated with high levels of nuclear β-catenin, suggesting Wnt-11 is not simply an indicator for activation of β-catenin-dependent signaling. Expression of Wnt-11 in colorectal cancer cell lines expressing low endogenous Wnt-11 inhibited β-catenin/Tcf activity and increased ATF2-dependent transcriptional activity. WNT11 gene silencing and antibody-mediated inhibition of Wnt-11 in colorectal cancer cell lines expressing high Wnt-11 reduced their capacity for invasion. Together, these observations suggest that Wnt-11 could be a potential target for the treatment of patients with invasive colorectal cancer.
Favorable Outcome in Patients with Pheochromocytoma and Paraganglioma Treated with 177Lu-DOTATATE
Authors: Vyakaranam Achyut Ram , Crona Joakim , Norlén Olov , Granberg Dan , Garske-Román Ulrike , Sandström Mattias , Fröss-Baron Katarzyna , Thiis-Evensen Espen , Hellman Per , Sundin Anders
Published: June 2019

Peptide receptor radiotherapy (PRRT) with 177Lu-DOTATATE has emerged as a promising therapy for neuroendocrine tumors (NETs). This retrospective cohort study aimed to assess the outcome of PRRT for 22 patients with histopathologically confirmed pheochromocytoma (PCC) and paraganglioma (PGL), of which two were localized and 20 metastatic. Radiological response utilized response evaluation criteria in solid tumors 1.1 and toxicity was graded according to common terminology criteria for adverse events version 4. Median 4 (range 3–11) 7.4 GBq cycles of 177Lu-DOTATATE were administered as first-line therapy (n = 13) or because of progressive disease (n = 9). Partial response (PR) was achieved in two and stable disease (SD) in 20 patients. The median overall survival (OS) was 49.6 (range 8.2–139) months and median progression-free survival (PFS) was 21.6 (range 6.7–138) months. Scintigraphic response >50% was achieved in 9/19 (47%) patients. Biochemical response (>50% decrease) of chromogranin A was found in 6/15 (40%) patients and of catecholamines in 3/12 (25%) patients. Subgroup analysis showed Ki-67 <15% associated with longer OS (p = 0.013) and PFS (p = 0.005). PRRT as first-line therapy was associated with increased OS (p = 0.041). No hematological or kidney toxicity grade 3–4 was registered. 177Lu-DOTATATE therapy was associated with favorable outcome and low toxicity. High Ki-67 (≥15%) and PRRT received because of progression on previous therapy could constitute negative predictive factors for OS.
Urinary Metabolic Signatures Detect Recurrences in Non-Muscle Invasive Bladder Cancer
Authors: Loras Alba , Martínez-Bisbal M. Carmen , Quintás Guillermo , Gil Salvador , Martínez-Máñez Ramón , Ruiz-Cerdá José Luis
Published: July 2019

Patients with non-muscle invasive bladder cancer (NMIBC) undergo lifelong monitoring based on repeated cystoscopy and urinary cytology due to the high recurrence rate of this tumor. Nevertheless, these techniques have some drawbacks, namely, low accuracy in detection of low-grade tumors, omission of pre-neoplastic lesions and carcinomas in situ (CIS), invasiveness, and high costs. This work aims to identify a urinary metabolomic signature of recurrence by proton Nuclear Magnetic Resonance (1H NMR) spectroscopy for the follow-up of NMIBC patients. To do this, changes in the urinary metabolome before and after transurethral resection (TUR) of tumors are analyzed and a Partial Least Square Discriminant Analysis (PLS-DA) model is developed. The usefulness of this discriminant model for the detection of tumor recurrences is assessed using a cohort of patients undergoing monitoring. The trajectories of the metabolomic profile in the follow-up period provide a negative predictive value of 92.7% in the sample classification. Pathway analyses show taurine, alanine, aspartate, glutamate, and phenylalanine perturbed metabolism associated with NMIBC. These results highlight the potential of 1H NMR metabolomics to detect bladder cancer (BC) recurrences through a non-invasive approach.
Recurrent DMD Deletions Highlight Specific Role of Dp71 Isoform in Soft-Tissue Sarcomas
Authors: Mauduit Olivier , Delcroix Vanessa , Lesluyes Tom , Pérot Gaëlle , Lagarde Pauline , Lartigue Lydia , Blay Jean-Yves , Chibon Frédéric
Published: July 2019

Soft-tissue sarcomas (STS) are rare tumors whose oncogenesis remains unknown and for which no common therapeutic target has yet been identified. Analysis of 318 STS by CGH array evidenced a frequent deletion affecting the DMD gene (encoding dystrophin isoforms) in 16.5% of STS, including sarcomas with complex genomics, gastrointestinal tumors (GIST), and synovial sarcomas (SS). These deletions are significantly associated with metastatic progression, thus suggesting the role of DMD downregulation in the acquisition of aggressive phenotypes. We observed that targeted deletions of DMD were restricted to the 5’ region of the gene, which is responsible for the transcription of Dp427. Analysis of STS tumors and cell lines by RNA sequencing revealed that only the Dp71 isoform was widely expressed. Dp427 depletion had no effect on cell growth or migration. However, Dp71 inhibition by shRNA dramatically reduced the cell proliferation and clonogenicity of three STS cell lines, likely by altering the cell cycle progression through the G2/M-phase. Our work demonstrates that DMD deletions are not restricted to myogenic tumors and could be used as a biomarker for metastatic evolution in STS. Dp71 seems to play an essential role in tumor growth, thus providing a potential target for future STS treatments.