bluuebunny/crossref_metadata_2025 huggingface dataset:
A significant relationship between personality traits and adhesive capsulitis
Authors: Chiaramonte Rita , Bonfiglio Marco , Chisari Sergio
Published: May 2020

SUMMARY OBJECTIVE We investigated the associations between adhesive capsulitis (AC) and a specific psychological profile. METHODS We assessed 72 patients with phase-II AC. In our study, 36 patients were affected by primary disease and 36 by secondary disease. The inclusion criteria were as follows: unilateral AC and pain in the shoulder for at least two months. The exclusion criteria were: psychiatric and neurological manifestations with a previous diagnosis and inability to comprehend the instruments. Outcomes were determined at 52 weeks. Shoulder pain severity was assessed with the Visual Analog Scale. We also measured the range of motion with a universal goniometer and the strength with the Medical Research Council. We assessed the personality traits of our patients with the Cloninger’s Temperament and Character Inventory and the Multidimensional Perfectionism Scale. RESULTS Patients with primary AC needed more time to improve the symptomatology compared to the group with the secondary disease (p<0.01). Patients with primary AC complained of severe and lasting pain more frequently than patients with the secondary disease (p< 0.01). In patients with primary disease, the prevalence of perfectionism, low levels of novelty seeking, and high levels of harm avoidance were 88.2 and 86.2%, and 80.4, respectively, and below 20 percent in patients with secondary AC disease. CONCLUSION We found a significant correlation between primary AC and particular personality traits, indicating an interaction between psychological and somatic factors.
Medical schools in Brasil: population, economic and historical analysis
Authors: Silva Ana Carolina Vieira da , Godoi Dannielle Fernandes , Neves Fabricio Souza
Published: May 2020

SUMMARY BACKGROUND To describe the current distribution and historical evolution of undergraduate courses in medicine in Brasil. METHODS Analytical cross-sectional study of secondary data. Through the Ministry of Education, the data of the medical courses were obtained, and through the Brazilian Institute of Geography and Statistics, the population and economic data of the Brazilian states were obtained. RESULTS In Brasil, there were 298 medical courses (1,42 courses / million inhabitants) in January 2018, totaling 31,126 vacancies per year, with 9,217 gratuitous vacancies (29.6%) and 17,963 vacancies in the hinterland (57, 7%). In Brazilian states, there are positive and statistically significant (p <0.001) correlations of the variables: “vacancies” and “population” (R 0.92); “vacancies” and “gross domestic product” (“GDP”) (R 0.83); “percentage of vacancies in the hinterland” and “population in the hinterland” (R 0.71) and “percentage of vacancies in the hinterland” and “GDP” (R 0.64). There was a negative and statistically significant correlation between “gratuitous vacancy percentage” and “GDP” (R -0.54, p = 0.003). More paid courses than gratuitous courses and more courses in the hinterland than in the capitals have been created since 1964, in proportions that have remained similar since then, but in higher numbers since 2002. CONCLUSIONS The distribution of medical courses in Brasil correlates with the population and economical production of each state. The expansion of Brazilian medical education, which has been accelerated since 2002, is based mainly on paid courses in the hinterland, in the same pattern since 1964.
NADPH Oxidase 5 upregulation is associated with lymphoma aggressiveness
Authors: Gonçalves João dos Santos , Carvalho Fabiano Lacerda , Coutinho Igor Cabral do Rego , Morais José Carlos Oliveira , Fortunato Rodrigo S , Milito Cristiane Bedran
Published: May 2020

SUMMARY OBJECTIVES Lymphomas are a heterogeneous set of malignant neoplasias of lymphoid B and NK/T mature and immature cells at various stages of differentiation. Genetic and molecular biology tools are used to appropriately classify the type and prognosis of the lymphomas, which have implications in therapeutic effectiveness. Among them, the nicotinamide adenine dinucleotide phosphate-oxidase (NADPH) oxidase (NOX5) enzymes have been explored. This study analyzed the expression of NADPH oxidase 5 in lymphoma tissue according to the degree of tumor aggressiveness. METHODS Slides from 64 patients with lymphoma who had paraffin-embedded tissue available were reviewed by two independent, experienced pathologists. They classified tumors according to the WHO classification (2017). NOX5 expression in tissues was assessed by immunohistochemical staining using a tissue microarray. The assay was interpreted using a scoring system of 0, 1, 2, and 3, for cytoplasmic staining of NOX5 corresponding to negative, weak, intermediate, and strong staining, respectively. We compared the expression of NOX5 in patients with aggressive versus non-aggressive lymphomas. RESULTS NOX5 expression was positive in 100% (27/27) of aggressive lymphomas and in 19% (7/37) of non-aggressive ones. The seven patients with positive expression of NOX5 presented intermediate staining (2); strong staining (3) was observed only in tissues of aggressive lymphomas, and negative and weak staining (0 and 1) were observed only in non-aggressive lymphomas. CONCLUSIONS Aggressive lymphomas overexpress NOX5 protein. The higher NOX5 expression in aggressive lymphomas can suggest an involvement of this enzyme on the acquisition of an aggressive phenotype in lymphoid neoplasia.
Association between body adiposity index and cardiovascular risk factors in teachers
Authors: Oliveira Renata Aparecida Rodrigues de , Moreira Osvaldo Costa , Mota Júnior Rômulo José , Marins João Carlos Bouzas
Published: May 2020

Abstract Body adiposity index (BAI) is a relatively recent evaluation method for the diagnosis of overweight and obesity, which takes into account simple measures. The aim of this study was to verify the association between BAI and cardiovascular risk factors in teachers. A cross-sectional study was conducted with 495 teachers from the city of Viçosa-MG. BAI, body mass index (BMI), abdominal circumference (AC), waist-to-hip ratio (WtHR), body fat percentage (%BF), systolic and diastolic blood pressure, fasting glucose, total cholesterol and triglycerides were evaluated. Associations between BAI (independent variable) and other variables (dependent variable) were evaluated through simple linear regression. Of the total participants, 32.12% presented high BAI and higher anthropometric, blood pressure and biochemical values (p<0.05). Higher percentage of high BAI was observed among men and with advancing age. Linear regression analysis showed positive association between BAI and other anthropometric measurements (p<0.001), with glucose (R²=0.024; p=0.001) and total cholesterol (R²=0.028; p<0.001). BAI was positively associated with the other anthropometric measures (BMI, %BF, AC and WtHR), and with the glucose and total cholesterol of evaluated teachers. Higher BAI was observed among men and with advancing age.
Association of cardiorespiratory fitness, physical activity level, and sedentary behavior with overweight in adolescents
Authors: Franceschin Marcelo Jannuzzi , Veiga Gloria Valeria da
Published: May 2020

Abstract Physical activity and sedentary behavior promote opposite effects on overweight and obesity, in adolescents; however little is known of their combined impact on these outcomes. We aimed to investigate if there were any associations between overweight, and physical activity level, cardiorespiratory fitness, and sedentary behavior, both as isolated variables and in combination. Data of 1,015students from two public and four private schools from the metropolitan area of Rio de Janeiro, Brazil were analyzed. Overweight was classified according to body mass index, whereas physical activity level was assessed by the International Physical Activity Questionnaire (IPAQ), cardiorespiratory fitness by a 9-minute test (T9), and sedentary behavior by a self-completed questionnaire, considering the time spent watching television as the main indicator. Associations were examined by binary logistic regression analysis. Odds ratios (ORs) and 95% confidence intervals (95%CIs) were used to measure the magnitude of the associations. IBM SPSS Statistics version 20 was used for all statistical analyses. Adolescents with poor cardiorespiratory fitness (OR=3.71; 95%CI=1.30-10.6) and a high degree of sedentary behavior (OR=1.73; 95%CI=1.24-2.42) had a bigger chance of being overweight. However the combination of these two categories in the same individual was not statistically associated with overweight. The study indicates that both sedentary behavior and poor performance on cardiorespiratory fitness test are significantly independent associated with overweight in adolescents.
Sobrepeso, obesidade e fatores associados aos adultos em uma área urbana carente do Nordeste Brasileiro
Authors: Melo Silvia Pereira da Silva de Carvalho , Cesse Eduarda Ângela Pessoa , Lira Pedro Israel Cabral de , Ferreira Lisianny Camilla Cocri do Nascimento , Rissin Anete , Batista Filho Malaquias
Published: May 2020

RESUMO: Introdução: As mudanças produzidas no processo saúde/doença, sobretudo no campo da nutrição, corroboram a substituição das carências nutricionais com emergência do excesso de peso (sobrepeso/obesidade). Objetivo: Analisar a prevalência e fatores associados ao excesso de peso em adultos residentes em uma área urbana carente do Recife, Nordeste do Brasil. Métodos: Trata-se de um estudo transversal analítico, com uma amostra de 644 adultos de 20 a 59 anos. Analisaram possíveis associações do excesso de peso aos fatores demográficos, socioeconômicos, comportamentais e morbidades por meio de regressão de Poisson, considerando como estatisticamente significantes aquelas com valor de p < 0,05. Resultados: A prevalência do excesso de peso foi de 70,3%, sendo menor na faixa de 20-29 anos e maior na faixa etária de 30-39 anos, e estabilizando-se nas demais. No modelo de regressão multivariado, foi observado que a faixa etária, classe econômica, diabetes mellitus (DM) e hipertensão arterial sistêmica (HAS) mostraram-se diretamente associada ao excesso de peso, enquanto a variável consumo semanal de feijão mostrou-se inversamente associada. A alta prevalência do excesso de peso encontrado pressupõe que as comunidades carentes das quais os indivíduos fazem parte já se incluem no processo de transição nutricional que está em curso no país. Conclusão: Os resultados significativos de sobrepeso/obesidade detectados na área urbana carente estudada, impõe a necessidade de incluir esse problema como prioridade de saúde pública nessas comunidades.
Body image, nutritional status and quality of life in long-lived older adults
Authors: Clementino Maria Daniela , Goulart Rita Maria Monteiro
Published: May 2020

Abstract Objective: To evaluate the body image and nutritional status (NS) of older adults aged 80 and over and its relation with quality of life (QoL). Method: A cross-sectional, quantitative study, with no intervention, using non-probabilistic sampling, was conducted from October 2016 to September 2017 with 103 older individuals aged ≥80 years old from the state of São Paulo. NS was evaluated according to OPAS/SABE; body image was evaluated by the Kakeshita fifteen silhouette scale, and the WHOQoL-bref and WHOQoL-old were used to measure QoL. The Chi-square test was used to verify the association between the studied variables and sex. To compare QoL with nutritional status and body image, the ANOVA Factor test was used. The level of significance was 5% (p<0.05). Results: The majority of the interviewees were female (69.2%) and the average age was 82.75 (±2.98). When comparing the perception of QoL with NS, there was a significant difference (p=0.027) in the self-evaluation of QoL of obese older adults only. The QoL related to body image of both sexes presented a significant difference (p=0.020) in the environmental domain of the WHOQoL-bref in the evaluation of body satisfaction. Conclusion: The body image distortion identified by these older adults did not interfere with their perception of QoL. However, when NS was considered, overweight older adults had a higher perception of QoL.
Evaluation of the clinical-functional vulnerability index in older adults
Authors: Alexandrino Arthur , Cruz Ellen Karolaine Lucena da , Medeiros Pedro Yan Dantas de , Oliveira Caio Bismarck Silva de , Araújo Djaine Silva de , Nogueira Matheus Figueiredo
Published: May 2020

Abstract Objective: To evaluate the clinical-functional vulnerability index (CFVI) of older adults and its relationship with socioeconomic, behavioral, clinical and therapeutic indicators. Method: A cross-sectional epidemiological study with a quantitative design was performed with 318 randomly drawn older adults registered with the Family Health Strategy. Data were collected through the CFVI-20 questionnaire and analysis was supported by descriptive, bivariate and multivariate statistics, with results with p-value <0.05 considered significant. Results: most older adults (59.1%) were considered frail or potentially frail. Among the groups studied, there was a statistically significant difference in the CFVI for the variables age group (p<0.001), functional literacy (p=0.001), alcohol consumption (p<0.001), physical exercise (p<0.001), self-reported health problems (p<0.001) and medication use (p<0.001), as well as a positive correlation with stress (r=0.135; p=0.016). In the multiple linear regression model, the set of sociodemographic predictor variables explained the frailty of the elderly by 30.4% (R2=0.304). Conclusions: The advancement of age, as a non-controllable variable, indicates a need to encourage the maintenance of functionality in old age, based on the health care strategies that prolong longevity with safety, autonomy and vitality.
Produções Científicas Brasileiras em Psicologia sobre Violência contra Mulher por Parceiro Íntimo
Authors: Curia Beatriz Gross , Gonçalves Victória Dias , Zamora Júlia Carvalho , Ruoso Aline , Ligório Isadora Silveira , Habigzang Luísa
Published: May 2020

Resumo A presente revisão sistemática objetivou analisar a produção científica de estudos empíricos da Psicologia brasileira sobre o fenômeno da violência contra a mulher por parceiro íntimo (VPI) publicada em revistas nacionais. Para tanto, os artigos foram pesquisados nas bases de dados SciELO, PsycINFO, PePSIC e Scopus, utilizando os descritores: “violência contra a mulher” ou “violência por parceiro íntimo” ou “violência conjugal” ou “violência doméstica”. As buscas também foram realizadas com descritores em inglês. Após aplicação de critérios de inclusão e exclusão, a amostra final foi composta por 29 artigos. Por meio da Análise Temática, os objetivos e principais resultados dos estudos foram agrupados de acordo com o tema principal. Os resultados indicaram uma distribuição proporcional de publicações entre os últimos cinco anos, com maior produção no Sul e no Sudeste do país. Houve um equilíbrio entre estudos quantitativos e qualitativos, sendo prevalentes estudos realizados com participantes, principalmente com mulheres, e estudos com entrevistas individuais e uso de instrumentos psicométricos. Conclui-se que há prevalência de estudos que retratam aspectos individuais em relação ao fenômeno, que há um menor número de pesquisas com caráter preventivo, bem como com avaliações de efetividade de intervenções propostas. Ademais, há escassez de estudos que incluam homens autores de violência, estratégia importante para uma mudança efetiva. A Psicologia enquanto ciência e profissão compõe a rede de enfrentamento ao fenômeno da VPI e não só atua em diferentes serviços de atendimento, como também na produção acadêmica e científica, fomentando novas pesquisas sobre a temática e políticas públicas de enfrentamento.
Que sociedade? Que teorizações?
Authors: Davel Eduardo Paes Barreto , Bispo Marcelo de Souza , Antonello Claudia Simone
Published: May 2020

Resumo De qual sociedade falamos quando pensamos em Organizações & Sociedade? Falamos da sociedade reconhecida pelo pesquisador como contexto plural, heterogêneo e enigmático. Cada sociedade a cada momento histórico nos instiga a renovar nossas formas de conhecê-la e sobre ela teorizar. O trabalho de teorizar é muito exigente, sobretudo em nosso contexto nacional, por causa de nossa tradição em não formar mestres e doutores voltados para enfrentar a tarefa e o esforço de teorizar. Essa fragilidade de teorização evidencia não apenas nossos problemas e desafios enquanto pesquisadores, ela reflete também na nossa prática educacional, especialmente a prática da pós-graduação.
AMBIVALÊNCIA DA ESCOLA E ADOLESCENTES INFRATORES
Authors: Moreira Jacqueline de Oliveira , Guerra Andréa Maris Campos , Pereira Marcelo Ricardo , Marinho Frederico Couto , Silva Bráulio Figueiredo Alves da , Wermelinger Claúdia
Published: May 2020

RESUMO Propomos uma reflexão sobre a ambivalência da escola sobre os adolescentes com trajetória infracional. Nosso problema consiste em demonstrar como a escola opera como lugar de exclusão, operando a partir da lógica segregatória do privilégio cultural. O método foi a revisão crítica da produção científica da psicologia e sociologia, usando como descritores “educação” e “adolescente em conflito com a lei” nas plataformas SciELO e Pepsic. Nos resultados constatamos que os índices de evasão escolar coincidem com a entrada na trajetória infracional dos adolescentes, fortalecendo o estigma e a exclusão. Perguntamos se, mesmo excludente e tão precária, não seria ainda essa escola formal melhor do que a não escola? Após análise da literatura defendemos a hipótese de que a escola pode funcionar como uma alça que oferece um ponto de apoio, proteção e referência para o adolescente com trajetória infracional, ainda que seu modelo seja anacrônico em relação ao efetivo exercício dessa possibilidade.
Percepções da integração ensino-serviço-comunidade: contribuições para a formação e o cuidado integral em saúde
Authors: Silveira João Luiz Gurgel Calvet da , Kremer Maira Marina , Silveira Maria Elisa Ugarte Calvet da , Schneider Ana Célia Teixeira de Carvalho
Published: May 2020

O presente estudo objetiva conhecer a percepção dos sujeitos no processo de ensino-aprendizagem-cuidado no Sistema Único de Saúde (SUS), com base no perfil profissional e nas competências e habilidades recomendadas nas Diretrizes Curriculares Nacionais (DCNs) dos cursos de graduação da saúde. Trata-se de pesquisa qualitativa realizada por meio de técnicas de entrevista não diretiva e grupos focais, envolvendo 42 participantes, sendo: professores, estudantes e gestores das instituições de ensino além de usuários, profissionais e gestores da Secretaria Municipal de Promoção de Saúde (SEMUS). A percepção dos diferentes sujeitos que produzem e vivenciam a integração ensino-serviço-comunidade (IESC) revela afinidade com o perfil profissional e com as competências e habilidades comuns recomendadas nas DCNs dos cursos de graduação da área da saúde. A IESC é compreendida como espaço necessário para a efetivação das DCNs e para se alcançar o perfil profissional proposto.
ASSOCIATION BETWEEN DIABETICS AND INTESTINAL CANCER WITH THE RISK OF MUTATION IN CD38 GENE IN IRANIAN POPULATION
Authors: SHOKRZADEH Mohammad , GOLEIJ Pouya , BEHRAVAN Elmira , GHASSEMI-BARGHI Nasrin , SALEHABADI Yaser , REZAEI Abolhasan
Published: May 2020

ABSTRACT BACKGROUND: Intestinal cancer often occurs in type 2 diabetic patients. The concept of increasing insulin levels and insulin-like growth factor in the blood with type 2 diabetes are stimulated with the growth and depletion of cloned cell walls, and the continuation of this process leads to the cellular deformation. This is the evidence for intestinal cancer in type 2 diabetes in population. OBJECTIVE: In this study, we aimed to find out the relationship between diabetics and intestinal cancer based on CD38 gene mutation. METHODS: Samples were collected from 200 population including normal and case ones. PCR products related to rs 6449181 of CD38 gene was amplified with ARMS-PCR technique, and a 420-bp sharp banding was observed as well. According three ARMS-PCR techniques, three primers were designed by oligo7 software. Primers include F1, F2 and R (amplifying for normal, mutant and reverse primer respectively). RESULTS: This band was observed using a primer F1 that carries the wild type nucleotide using a primer, and when it is used with the F2 primer, it brings the mutant primer to populations of patients with diabetes and diabetes-cancer. In addition, the clinical results including body mass index, blood glucose and insulin level were analyzed. The means ±SD and Tuckey’s post hoc test were significant between the clinical characterization parameters between cases and healthy populations. The allelic gene frequencies and Hardy-Weinberg equilibrium between nucleotides were evaluated, and the significant level between the alleles and gene frequencies was observed. CONCLUSION: In general, the current study found that there is a relationship between diabetes and intestinal cancer among the studied populations.
Climate risk zoning for gladiolus in the state of Rio Grande do Sul, Brazil
Authors: Uhlmann Lilian Osmari , Streck Nereu Augusto , Becker Camila Coelho , Tomiozzo Regina , Schwab Natalia Teixeira , Ortiz Vithória Morena
Published: May 2020

Abstract: The objective of this work was to develop a climate risk zoning for the gladiolus (Gladiolus x grandiflorus) crop in the 497 municipalities of the state of Rio Grande do Sul, Brazil. The PhenoGlad model was used to simulate crop development and the occurrence of damages. The model was run for four developmental cycles of gladiolus over 34 years and in 23 locations in the state. The probabilities of 10, 20, and 30% damages due to low and high temperatures were used to define periods suitable for planting. Rio Grande do Sul is adequate for growing gladiolus during most of the year. In the coldest areas of the state, the inadequate planting dates are from March until mid-May due to frost damage. In the hottest regions, the inadequate planting dates are greater from October to January due to heat damage. Because it is stricter, the 10% level of damage is considered more appropriate to define the periods recommended for planting.
MORPHOMETRY OF THE POSITIONING OF CORTICAL TRAJECTORY PEDICLE SCREWS IN BRAZILIANS
Authors: GOSENDE FERNANDO MAGALHÃES , RESENDE ROGÉRIO LÚCIO CHAVES DE , LOPES JUNIOR CARLOS BAUER NAMEM , LEAL JEFFERSON SOARES , SANTANA PAULA SILVEIRA , FARIA ÂNGELO RIBEIRO VAZ DE , FRANÇA LUIZ CLAUDIO DE MOURA
Published: May 2020

ABSTRACT Objective Morphometric study of the positioning of the cortical trajectory pedicle screw in the lumbar spine of Brazilian patients of different sexes and ages, through the use of computed tomography images, in order to obtain more reliable data about cortical screw insertion and the variations observed, providing assistance for a safer, more effective approach with fewer complications. Methods Selection of 100 patients from a database, alternating by sex, measuring the length, diameter, cephalic angulation, and lateral angulation of the vertebrae from L1 to L5. Results Statistically significant measurements were obtained for the four different parameters in relation to sex. The mean age was 56, with a minimum of 20 and a maximum of 87 years. The L4 and L5 screws showed a reduction in relation to the other levels, while the width showed a progressive increase starting at L3. Lateral angulation was the parameter with the least variation among the levels, while there was greater variation and a reduction from L4 to L5 in cephalic angulation. Conclusion Statistically significant results were obtained for length, diameter, lateral and cephalic angulation. Sex was a significant factor in spine surgery instrumentation using the cortical trajectory pedicle screw technique. Level of evidence I; Diagnostic study (investigation of an examination for diagnosis).
THE SINS SCALE IN THE EVALUATION OF STABILITY IN PATIENTS WITH SPINAL METASTASIS
Authors: LUGÃO ARIEL FALBEL , SILVEIRA JUNIOR CLOVIS CASTANHO , TEIXEIRA WILLIAM GEMIO JACOBSEN , CRISTANTE ALEXANDRE FOGAÇA
Published: May 2020

ABSTRACT Objective To evaluate the distribution of patients seen in the emergency care unit of the Instituto do Câncer do Estado de São Paulo in the categories “stable”, “indeterminate” and “unstable” as classified by the SINS scale. Methods The medical charts of patients treated between May and September 2013 were reviewed. Patients with a diagnosis of spinal metastasis were analyzed and data on age, sex, primary tumor location, neurological status, and the presence and intensity of pain at rest and in movement were obtained. The SINS criteria were used to evaluate the radiological involvement of the spine. Results We included 81 patients with a mean age of 59.57 years; 32 (39.51%) men and 49 (60.49%) women. Breast (19.75%), prostate (18.52%) and lung (17.28%) were the most common primary tumor sites. Only 18 patients (22.22%) had a single lesion and 51 (62.96%) had 3 or more metastatic lesions. Of the total, 56 (69.14%) were of undetermined stability, 19 were stable (23.46%) and 6 were unstable (7.41%). Twenty-two (27.2%) presented neurological deficit in the physical examination. None of the patients with severe deficit, Frankel A or B, were stable according to the SINS classification. All unstable lesions presented with kyphotic and/or scoliotic deviation (p <0.001). Most patients with undetermined lesions (78.6%) and all patients with unstable lesions had mechanical pain (p = 0.001). Conclusion In this case series, there was a high rate of patients classified by the SINS scale as of undetermined instability (69.14%). There was a high number of patients with multiple metastases (62.96%), which was not considered a modifier of the SINS instability criteria and which needs to be the focus of future studies. Level of evidence IV; Case Series.
TRABALHO E SAÚDE EM TEMPOS DE PANDEMIA PELA COVID-19: CUIDADO DE SI E DIREITO À AUTOPROTEÇÃO DAS MULHERES
Authors: Santos Gabriela de Brito Martins , Lima Rita de Cássia Duarte , Barbosa Jeanine Pacheco Moreira , Silva Mayara Ciciliotti da , Andrade Maria Angélica Carvalho
Published: May 2020

A pandemia pela COVID-19 não é apenas um problema de saúde, ela é considerada um choque profundo para nossas sociedades e economias, colocando em evidência uma crise de prestação de cuidados, onde os profissionais de saúde, em especial as mulheres, estão no centro dos esforços de atendimento e respostas. O presente artigo analisou e problematizou as políticas de cuidado trazendo para a cena o direito à autoproteção das mulheres, profissionais de saúde, durante a pandemia da COVID-19. À luz do conceito de cuidado de si e biopolítica, em Foucault, afirma-se a produção do cuidado como criador de valor, respeito pela vida de todas e todos. A crise do cuidado incita um olhar do corpo feminino mergulhado em um campo político, fazendo-se necessário desmistificar a glamourização do cuidado como “coisa” de  mulher, um sacerdócio que inclui sacrifícios e renúncias, de  anjos de branco,  sempre dispostas a se sacrificar pelo outro e cujo trabalho não tem valor e reconhecimento. Diante disso, este artigo parte da aposta coletiva de outra estética de existência, que afirma e opera políticas públicas que visem incondicionalmente a garantia do direito à vida e proteção.
Impact of Delayed Neoadjuvant Systemic Chemotherapy on Overall Survival Among Patients with Breast Cancer
Authors: de Melo Gagliato Debora , Lei Xiudong , Giordano Sharon H. , Valero Vicente , Barcenas Carlos H. , Hortobagyi Gabriel N. , Chavez-MacGregor Mariana
Published: May 2020

Background

Delays in the initiation of therapy among patients with early stage breast cancer (BC) can negatively affect outcomes. Patients treated with neoadjuvant systemic chemotherapy (NSC) usually display tumors with high-risk features. Considering these high-risk characteristics and the evidence supporting adverse outcomes associated with delays in adjuvant chemotherapy initiation, we sought to determine whether a delay in NSC initiation is associated with overall survival (OS).

Methods

We identified patients diagnosed between January 1995 and December 2015 with invasive primary BC (stage I–III) who received NSC at MD Anderson Cancer Center. Patients were categorized according to their time from BC diagnosis to NSC (in days) into three subgroups: 0-30, 31–60, and ≥61 days. Primary endpoint was OS. Descriptive statistics and Cox's proportional hazard models were used.

Results

A total of 5,137 patients were included. Median follow-up was 6.5 years. The 5-year OS estimates according to time to NSC were 87%, 85%, and 83% in patients who received NSC within 0–30, 31–60, and ≥61 days after diagnosis, respectively (p = .006). In multivariable analysis, compared with time to NSC of 0–30 days, delayed NSC ≥61 days was associated with an increased risk of death (31–60 days: hazard ratio [HR] = 1.05 [95% confidence interval (CI) 0.92–1.19]; ≥61 days, HR = 1.28 [95% CI 1.06–1.54]). In stratified analyses, the association between delay in NSC initiation and increased risk of death was statistically significant for patients with stage I and II BC (31–60 days: HR = 1.22 [95% CI 1.02–1.47]; ≥61 days, HR = 1.41 [95% CI 1.07–1.86]) and among patients with HER2-positive tumors ( ≥61 days, HR = 1.86 [95% CI 1.21–2.86]).

Conclusion

A delay in NSC initiation of more than 61 days after BC diagnosis was associated with an increased risk of death. Early initiation of NSC should be a priority; multidisciplinary teams must focus on coordination of care and patient-centered, timely treatment planning and delivery.

Implications for Practice

The results of this study showed that a delay in neoadjuvant systemic chemotherapy initiation of more than 61 days after breast cancer diagnosis is associated with an increased risk of death; therefore, efforts must focus on early initiation of therapy, which should be a priority. Multidisciplinary teams must enhance coordination of care and patient-centered, timely treatment planning and delivery.
A Retrospective Analysis of the Safety and Activity of Lutetium-177-Prostate-Specific Membrane Antigen Radionuclide Treatment in Older Patients with Metastatic Castration-Resistant Prostate Cancer
Authors: Leibowitz Raya , Davidson Tima , Gadot Moran , Aharon Margalit , Malki Avraham , Levartovsky Meital , Oedegaard Cecilie , Saad Akram , Sandler Israel , Ben-Haim Simona , Domachevsky Liran , Berger Raanan
Published: May 2020

Background

Prostate cancer is a common malignancy of the elderly, and with the aging of the population, the need is growing for therapies suitable for this age group. Lutetium-177–prostate-specific membrane antigen (Lu-PSMA), a radiolabeled small molecule, binds with high affinity to prostate-specific membrane antigen, enabling beta particle therapy targeted to metastatic castration-resistant prostate cancer (mCRPC). In a recent single-arm phase II trial and a subsequent expansion cohort, a prostate-specific antigen (PSA) decline of ≥50% was observed in approximately 60% of patients receiving Lu-PSMA. Taking into account the specific challenges and potential toxicities of Lu-PSMA administration in elderly men, we sought to retrospectively analyze the safety and activity of Lu-PSMA in men aged older than 75 years with mCRPC.

Patients and Methods

The electronic medical records of 24 patients aged older than 75 years treated with Lu-PSMA “off-trial” were reviewed, and clinical data were extracted. Clinical endpoints were toxicity and activity, defined as a PSA decline ≥50%. Descriptive statistics were performed using Excel.

Results

The median age at treatment start was 81.7 years (range 75.1–91.9). The median number of previous treatment lines was four. The number of treatment cycles ranged from one to four; the mean administered radioactivity was 6 GBq per cycle. Treatment was generally tolerable; side effects included fatigue (n = 8, 33%), anemia (n = 7, 29%), thrombocytopenia (n = 5, 21%), and anorexia/nausea (n = 3, 13%). Clinical benefit was observed in 12 of 22 patients (54%); PSA decline above 50% was observed in 11 patients (48%) and was associated with significantly longer overall survival.

Conclusion

Our results indicate that Lu-PSMA is safe and active in elderly patients with mCRPC.

Implications for Practice

Lutetium-177–prostate-specific membrane antigen (Lu-PSMA), a radiolabeled small molecule, binds with high affinity to prostate-specific membrane antigen, enabling beta particle therapy targeted to metastatic castration-resistant prostate cancer (mCRPC). The recently published single-arm phase II trial with Lu-PSMA, describing its safety and activity, did not include patients aged older than 75 years. In this study, Lu-PSMA activity was retrospectively analyzed in patients aged older than 75 years and results indicate that treatment was tolerable and similarly active in this age group, with no new emerging safety signals. Despite the small cohort size, this analysis suggests that Lu-PSMA can serve as an advanced palliative treatment line in mCRPC in elderly patients.
An extreme learning machine model for geosynthetic-reinforced sandy soil foundations
Authors: Raja Muhammad Nouman Amjad , Shukla Sanjay Kumar
Published: May 2020

In the past, several experimental and theoretical studies have been carried out to evaluate the ultimate bearing capacity (UBC) of geosynthetic-reinforced sandy soil foundations (GRSSFs). The experimental studies consist of model footing load tests which are expensive and time consuming whereas the results obtained by theoretical expressions often lack consistency. In the study reported in this paper, a cost-effective, extreme learning machine (ELM) model was used for the first time to obtain a more realistic prediction of the UBC of a GRSSF. A large dataset consisting of actual field and laboratory measurements of UBC was used to develop and validate the model. Its predictive performance was then compared against robust machine learning regression models and traditional theoretical methods. The study shows that the proposed model is useful and attains an adequate level of accuracy in predicting the UBC of GRSSFs when compared with other data-driven models and some traditional methods. The research also shows that the ELM technique is a realistic and reliable approach that could be employed in geotechnical engineering intelligent systems for the prediction of multivariate non-linear problems.
Flow behaviour around spur dyke founded in cohesive sediment mixtures
Authors: Lodhi Ajay Singh , Jain Rajesh Kumar , Sharma Pramod Kumar
Published: May 2020

This paper presents the results of flow and turbulence characteristics measured by a down-looking 16 MHz micro acoustic Doppler velocimeter around partially submerged spur dyke founded in a clay–gravel sediment mixture. Velocity and turbulence data were collected at various cross-sections at the wake and upstream sides of the spur dyke within and outside of the scour hole. The longitudinal velocity, turbulence intensities and Reynolds stresses were measured and quantitative analysis was carried out. Very small values of the longitudinal velocity component (negative) were obtained within the scour hole whereas larger values were obtained beyond the scour hole region. Turbulence intensities and Reynolds stresses were larger within the scour hole in the wake zone of the spur dyke. Bursting events, including outward interaction, ejection, inward interaction and sweep, were also analysed around the spur dyke. Quadrant analysis of the velocimeter data showed that the values of outward and inward interaction were higher within the scour hole around the spur dyke compared with the values of ejection and sweep events, while outside of the scour hole, the values of ejection and sweep events were higher than the values of outward and inward interaction events.
Phosphate Buffered Saline (PBS) v2
Authors: Institute for Brain Science Allen
Published: May 2020

This protocol is used to prepare Phosphate Buffered Saline (PBS). PBS (-) and PBS (+) which includes Tween are used as biologically neutral wash solutions in many processes including In Situ Hybridization (ISH), Immunohistochemistry (IHC) and Fixation. Note: Research reported in this publication was supported by the National Institute Of Mental Health of the National Institutes of Health under Award Number U19MH114830. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Find Proteins of Unknown Function (PUFs) using Plantannot - Protocol B v1
Authors: Viana Marcos , Mudadu Mauricio , Zerlotini Adhemar
Published: May 2020

Find PUFs from organisms whose proteins are not yet in the NCBI “nr” database and have no protein domain signatures.
Immunohistochemical detection of Notch1 protein in ameloblastoma, odontogenic keratocyst and glandular odontogenic cyst in a sample of Egyptian population: A Retrospective cohort study v1
Authors: Rizk Hadeer
Published: May 2020

Odontogenic tumors (OGTs) are oral tumors that are derived from cells of odontogenic apparatus and their remnants. OGTs are subclassified into epithelial, mesenchymal and mixed in relation to their histogenesis. Although they are relatively uncommon, constituting nearly 1% of all oral tumors, they however represent an important aspect of oral and maxillofacial pathology. Malignant OGTs are exceedingly rare, the majority of OGTs are benign, and some show a pattern of local aggression and high recurrence rate such as ameloblastoma). On the other hand, odontogenic cysts are more commonly encountered. They can be classified into inflammatory and developmental cysts. Most developmental cysts have good prognosis following enucleation, but others bare a high recurrence rate following the same treatment modality, like odontogenic keratocysts and glandular odontogenic cysts. The Notch gene provides instructions for making a protein called Notch, a member of the Notch family of receptors. Mammals have four Notch genes (NOTCH1-4). Notch receptors are large transmembrane proteins that normally communicate signals upon binding to transmembrane ligands expressed on adjacent cells. Attachment of a ligand to the Notch receptor sends signals that are important for normal development of many tissues throughout the body, both before birth and after. It can play a role in self-annihilation of the cell (apoptosis), cell division (proliferation) and maturation (differentiation). Owing to the limited number of studies that investigate the possible mechanism of involvement in Notch1 protein in growth and local invasion of ameloblastoma, odontogenic keratocyst and the lack of such studies on glandular odontogenic cyst, the present aim is to employ a study using immunohistochemical detection of Notch1 protein in the fore-mentioned lesions in order to helpprovide a clearer understanding of such lesions and allow usage of that knowledge in future treatment modalities.
Injection of Viral Tracers by Nanoject v3
Authors: Institute for Brain Science Allen
Published: May 2020

This protocol describes the delivery of a neuronal tracer using the Nanoject II. The surgery uses a stereotaxic system to target specific brain coordinates in the mouse. Note: Research reported in this publication was supported by the National Institute Of Mental Health of the National Institutes of Health under Award Number U19MH114830. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Making inexpensive light-powered Chlamydomonas reinhardtii (a green micro-alga) bead bracelets/necklaces for teaching the interplay of photosynthesis and cellular respiration to K4-K16 students. v1
Authors: Mitra Mautusi , Broom Sara , Kysis Pinto not provided , Sovi-Mya Doan Wellons not provided , Dominique Roberts Ariel
Published: May 2020

Scientific concept: Cellular respiration oxidizes organic chemicals and releases CO2 into the environment and photosynthesis converts CO2 into fixed carbon in the presence of light.Irrespective of the light conditions, respiration in live cells in the beads will release CO2 that will dissolve in water inside the bracelet/necklace in which the beads are immersed to generate carbonic acid. Conversely in the light, photosynthesis in the algal cells in the beads will remove CO2 from the water surrounding the beads. Hence pH of the water inside the algal bead bracelets will be acidic in the dark and alkaline in the light. Students can monitor the dramatic color changes in a gradient fashion in the water inside the bracelet that is induced by the relative rates of photosynthesis/cellular respiration. Students can measure pH of the water inside the bracelets/necklaces using pH testing strips. This protocol might be also useful for bioenergy researchers who are interested in exploring the use of immobilized motile micro-algae for biofuel production. Applications:This educational protocol can be used to teach the interplay of photosynthesis and cellular respiration to K4 - college Biology students in a fun and engaging way. The lab activities can be customized according to grade levels. Students will make their Chlamydomonas beads and use these beads to make algae bead bracelets or necklaces to test the opposing nature of chemical reactions of cellular respiration and photosynthesis. This interplay can be studied by visually monitoring the water color/pH changes induced by relative rates of photosynthesis and cellular respiration under light and in darkness. Alternatively, this protocol can be used by educators at institutions with limited resources who do not have access to an oxygen electrode to comparatively study relative rates of photosynthesis in Chlamydomonas wild type and a photosynthetic mutant strain using strain specific-algae beads that approximately the same number of cells per bead.
La Literatura grotesca en Europa (siglos XVI-XX)
Authors: Ginés Orta Juan Carlos
Published: May 2020

La literatura grotesca en Europa (siglos XVI-XX) es un estudio sobre la estética del grotesco en la literatura. Este libro ayuda a responder a la pregunta: ¿Qué es exactamente eso que llamamos "grotesco", esa estética que fascina y que domina todas las artes, no solamente las pictóricas, sino también las literarias, fotográficas, cinematográficas, gráficas, etc.? El trabajo se centra en el grotesco literario (y más exactamente, en la literatura europea), cuyo estudio es relativamente reciente, pero también hay alguna referencia a otras expresiones artísticas (pintura, cine, escultura…). El corpus literario que se usa va desde el siglo XVI hasta el siglo XX, de la Península Ibérica a Rusia.
The Problem of the Quality of Work Programs of a Practical Psychologist in Education and Criteria for their Assessment
Authors: Zabrodin Yu.M. , Pakhalyan V.E.
Published: May 2020

The analysis of the problem of assessing the content of teaching materials in the system of the Service of Practical Psychology of Education is given. Attention is drawn to the existing difficulties in determining the main content of the methodology of practical psychology itself. The data of a qualitative analysis of regional programs sent to the “All-Russian competition of the best psychological and pedagogical programs and technologies in the educational environment” in 2018 and 2019 are presented. An authors’ understanding of the essence of practical psychology is proposed, on the basis of which the main criteria for evaluating the programs of work of a teacher-psychologist and the actions necessary to solve the main task of modern psychological science and practice are highlighted — ensuring the quality of work of a practical psychologist.
"Amnesty through the Back Door" for Nazi Criminal Otto Bradfsch
Authors: Grakhotskiy A. P.
Published: May 2020

In the 1960s, the process of criminal prosecution of Nazi criminals became more active in Germany. Former members of the einsatzkommand, SS members, SD, and police services who took part in the mass extermination of Jews in Eastern Europe were brought to justice. However, these trials resulted in unreasonably lenient sentences to Nazi criminals handed down by the courts. Often, the convicts managed to avoid imprisonment altogether.

By the example of two trials against the commander of the einsatzkommando 8, Lodz Otto Bradfisch the head of the Gestapo Department and the chief burgomaster the paper aims to show what legal assessment the crimes of the Holocaust in Eastern Europe the German justice of the 1960s received and how the Nazi criminals managed to evade serving their sentences.

The Munich and Hanover jury found the convinced nazi O. Bradfish, who was guilty of killing 37 thousand Jews (according to the most minimal calculations), to be only an "accomplice", "blindly implementing the criminal will of the Fuhrer". Such court decisions fully fit into the general conceptual approach of West German justice to assessing the crimes of the Holocaust. This approach made it possible to remove responsibility for the genocide of Jews not only from the Nazi criminals who appeared before the courts in the 1960s, but also from the entire German society. Placing full responsibility on Hitler and his inner circle, the German society refused to take seriously even the smallest penalties that the so-called "accomplices"received. Bradfish was sentenced to 13 years in prison. However, under the pretext of "poor health", without declaring an amnesty, on the basis of questionable medical reports and decisions of local justice bodies, the convicted person was released early. The narrative of O. Bradfisch showed that the sentences of the West German courts turned into a mockery of the memory of millions of victims of Nazi crimes.
Classifcation of Persons Sentenced to Imprisonment in Spain
Authors: Siryakov A. N.
Published: May 2020

The paper is devoted to the legal regulation of the initial and subsequent assignment of the first, second, third or individual degrees to convicts held in Spanish prisons. The concept and tasks of the penitentiary classification are formulated, its procedure, criteria, and exceptions to the rules are revealed. The distribution of convicts by degree has a legal consequence. It consists in sending convicts to penitentiary institutions (departments) of a certain regime with appropriate conditions for serving their sentences. The subjects involved in the procedure for awarding a degree or revising a degree (progress or regression) are the penitentiary institutions and their governing bodies, and in relation to the qualification to the third (mildest) degree, the penitentiary supervision court. Attention is given to the most important principle of the Spanish penitentiary system — the scientific individualization of punishment. In its purest form, it means that the assignment of a degree to a convicted person is not tied to the real term of serving the sentence, the type of crime, or its nature, but is determined solely by personal data and an individual correction program. However, at present, the initial classification and revision of the degree depend not only on these factors, but also on the criminal law, criminological and penal data. A special feature is also the possibility of awarding an individual degree, which combines the characteristics of various degrees and is an example of flexibility in the process of achieving the main goal of penitentiary activities — re- education and social reintegration of prisoners sentenced to imprisonment. In Russian penal enforcement legislation, classification techniques are also used in the distribution of convicts, when the court appoints the type of correctional institution, and the administration of the institution changes the conditions of detention and makes a request to change the type of institution. In the latter two cases, it is quite possible to improve domestic legislation by establishing criteria and a classification system based on correction and treatment of the main means of correction.