bluuebunny/crossref_metadata_2025 huggingface dataset:
Predicting groundwater level based on remote sensing and machine learning: a case study in the Rabat-Kénitra region
Authors: Elmotawakkil Abdessamad , Sadiki Abdelkhalik , Enneya Nourddine
Published: September 2024

Groundwater is essential for sustaining water needs, industrial growth, agriculture, and ecosystems, particularly in arid regions. This study uses data from GRACE and MODIS satellites, integrating environmental variables like land surface temperature, soil moisture, terrestrial water storage, precipitation, and vegetation indices to predict groundwater levels in Morocco’s Rabat-Salé Kenitra region. These environmental variables serve as input parameters, with the output being the predicted groundwater level. Advanced machine learning models, including Gradient Boosting Regression (GBR), Support Vector Regression (SVR), Random Forest (RF), and Decision Tree (DT) were employed to capture the relationships between these variables and groundwater levels. The GBR model showed superior performance with an R2 value of 0.99, a Mean Absolute Error (MAE) of 1.94, and a Root Mean Squared Error (RMSE) of 2.98, significantly improving over traditional methods that struggle with non-linear relationships and data noise. Compared to existing methods, our approach offers enhanced accuracy and robustness due to the GBR model’s ability to handle complex and non-linear relationships. This study demonstrates the advantages of integrating diverse environmental datasets with advanced machine learning techniques, improving groundwater management strategies and prediction reliability, especially in regions facing significant water scarcity and climate change impacts.
ANÁLISE DOS EFEITOS CAUSADOS NA SAÚDE DA POPULAÇÃO DO BAIRRO DO JADERLÂNDIA NO MUNICÍPIO SANTARÉM-PA
Authors: Paz de Araújo Aldair José , Gisele Moita de Aguiar  , Iana Vitória Dias Almeida  , Rayssa Santos Cipriano  , Sara Batista de Freitas  , Lúcia Dias da Silva Guerra
Published: September 2024

Este estudo tem por objetivo compreender os efeitos causados pelos determinantes sociais na saúde da população no contexto do espaço territorial estudado. Buscou-se evidenciar fatores relevantes de reflexão acerca desses efeitos e a interferência destes na qualidade de vida, nas interações sociais e, principalmente, no estado de saúde da população. A partir da abordagem qualitativa foi possível conduzir entrevistas in loco seguidas de visitas na Unidade Básica de Saúde. Realizou-se um levantamento sobre as condições econômicas, políticas e interações sociais observadas. Identificou-se a disparidade entre as realidades econômicas e os extremos sociais no mesmo território, que evidenciam as iniquidades em saúde. Assim, foi possível traçar um panorama da situação de saúde e sua relação com os determinantes sociais atuantes, analisando a influência que estes possuem como fatores impactantes na saúde da população. 
Palavras-chave: saúde; território; políticas públicas; planejamento estratégico; determinantes sociais.
USO DE PRÁTICAS INTEGRATIVAS E COMPLEMENTARES EM ESCOLAS PÚBLICAS NO INTERIOR DO RIO GRANDE DO NORTE
Authors: Marques Victor Henrique Soares Silva , Costa Lariza Maria da , Araújo Isabelle Maria Mendes de , Carvalho Haroldo Loguercio
Published: September 2024

O Programa de extensão Trilhas Potiguares, realizado em 2023 na cidade de Serra Negra do Norte, desenvolveu um conjunto de ações no município que contribuíram para a troca de saberes entre a universidade e a comunidade. Umas das demandas levantadas pelos coordenadores locais do município foi a saúde mental dos estudantes. A partir dessa necessidade foi desenvolvida a ação com Práticas Integrativas e Complementares, em três escolas, com sete turmas no total, foram desenvolvidas as seguintes práticas: aromaterapia, yoga e meditação. O objetivo dessa ação foi apresentar as práticas terapêuticas como uma estratégia para prevenir agravos à saúde e reforçar a importância da construção de laços terapêuticos e a conexão entre ser humano, meio ambiente e sociedade.
Palavras-chave: extensão; práticas integrativas e complementares; saúde mental.
Investigação sobre a percepção de alunos do ensino fundamental acerca da caça de animais silvestres no município de Imbituba – SC
Authors: Rafaela Cardoso Ramos  , Diego dos Anjos Souza  , Hellen Cristina Freitas Targino  , Sabrina Duarte Rosa  , Maiara Aparecida Aniceto  , Lara Manuela do Nascimento
Published: September 2024

O presente estudo objetivou verificar a existência da caça ilegal no município de Imbituba (SC), de modo a averiguar o status de conhecimento de alunos acerca da biodiversidade, a cultura do consumo de carne em diferentes áreas da região, em auxílio à elaboração do Plano Municipal de Conservação e Recuperação da Mata Atlântica (PMMA), da Secretaria Municipal de Meio Ambiente de Imbituba. Para tal, como metodologia, elaborou-se um questionário voluntário qualiquantitativo, aplicado em escolas públicas e privadas com alunos do 6.º ao 9.º ano do ensino fundamental. Os resultados demonstraram que há ocorrência de caça no município e que os alunos possuem um breve conhecimento referente às questões abordadas, ainda que não saibam definir e/ou justificar suas respostas. Ações voltadas à educação ambiental são necessárias para sensibilizar a população sobre os riscos da caça e contribuir para a conservação dos animais silvestres
Exploring the Current Potential of Snake Venom Disintegrins as Chemotherapeutic Agents: A Narrative Update on their Clinical Translational Potential
Authors: Geevarghese Abin V. , Maria Jolly Aleeta , Thomas Jaya
Published: September 2024

A potential source of multiple enzymatic and nonenzymatic molecules that protect the
host is snake venom. In these venoms, several kinds of peptides that have significant beneficial
effects were discovered and characterized. Disintegrins act by blocking integrins on transmembrane
cell surfaces, inhibiting tumor cells from adhering, migrating, forming new blood vessels,
and spreading. This has an important effect on delaying the development, neovascularization, and
growth of tumors. These cells are ideal candidates for novel therapies for the management of
malignancies due to their tumor selectivity and decreased size. As research findings in various in
vivo & in vitro, disintegrin proteins are low-molecular-weight polypeptides that are found in the
venom of vipers and rattle snakes. They act by blocking the β1 and β3 integrin receptors. Angiogenesis
and metastatic processes in cancer are mediated through β1 and β3 integrins. Hence,
blocking β1 and β3 integrin receptors plays a prominent role in blocking the progression of cancer,
and disintegrins seem to be promising candidates for antineoplastic therapies. The disintegrins
with anticancer properties include Crotatroxin 2, Alternagin-C, Rubistatin, Leucurogin, Mojastin-
1, Contortrostatin, Acostatin, Vicrostatin, Tzabcan, Eristostatin, Purpureomaculatus, Saxatilin,
Lebein, Salmosin, and Rhodostomin. The above mentioned disintegrins were considered
in this study. This review is based on the origins of these disintegrins, their modes of targeting,
their categorization, and their inherent anticancer potential.
ANALISIS TINGKAT KESEJAHTERAAN RUMAH TANGGA NELAYAN
Authors: Yahya Kholid , Pudjihardjo M.
Published: September 2024

The study was conducted on a fisherman's household in Weru Village, Paciran district of Lamongan. The objective of the study was to find out the relationship between income, consumption, housing conditions, accommodation facilities, family members' health, access to health services, children's access to education, and access to transport facilities to the well-being of fishermen's households, both simultaneously and partially. The method used in this research uses associative descriptive methods. The study used 91 as a sample of the study using double linear regression analysis. Hypothesis testing in this study uses test-F and test-t statistics. The statistical analytics process uses the SPSS for Windows 25 program. According to the results of the study, the influence of income, consumption, housing conditions, accommodation facilities, the health of family members, access to health services, children's education, and access to transport facilities on the well-being of fishermen's households, carried out with a determination coefficient analysis, has an impact of 0.998 or 99.8%, i.e. income, consumer, conditions of housing, accommodations, family members' health, health of health services access, child education access, and transport facility access have an effect of 99.8% on fisherman's welfare and the remaining 0.2% is influenced by other factors not studied by the author.
Good looking and gaya hidup modern mahasiswa diploma perbankan di Malang
Authors: Ayu Diah Pusfita , Meiji Nanda Harda Pratama
Published: September 2024

Fenomena good looking sebagai persyaratan bagi calon mahasiswa D III Perbankan di kota Malang menjadi salah satu isu yang viral di kalangan masyarakat di ruang media sosial beberapa waktu terakhir. Artikel ini bertujuan untuk mengkaji fenomena good looking dan perspektif lifestyle pegawai bank dalam konteks mahasiswa D III Perbankan di kota Malang sebagai calon pegawai bank. Pendekatan yang digunakan adalah pendekatan kualitatif dengan teknik pengumpulan data menggunakan teknik observasi dan wawancara secara langsung dengan informan. Berdasarkan penelitian yang telah dilakukan didapatkan hasil bahwa persyaratan good looking yang telah diterapkan merupakan salah satu upaya yang dilakukan oleh pihak kurikulum dari kampus dalam memenuhi kriteria yang dimiliki oleh industri. Ekspektasi yang dimiliki oleh mahasiswa D III Perbankan tentang lifestyle pegawai bank sebagai seorang calon pegawai bank adalah gaya hidup yang hedon demi menunjang penampilan mereka selama bekerja dan melayani nasabah.
Nongkrong dalam perspektif Dramaturgi Erving Goffman
Authors: Iqbal Muhammad Falih , Handoyo Pambudi , Harianto Sugeng
Published: September 2024

Pelajar di Surabaya nongkrong di kafe dan restoran tidak hanya untuk mengkonsumsi produk yang ditawarkan tetapi juga untuk membentuk makna dan simbol yang memaknai identitas sosialnya. Penelitian ini menjelaskan tentang nongkrong dalam perspektif Dramaturgi Erving Goffman. Dengan melakukan wawancara terhadap mahasiswa di Surabaya, penelitian ini merumuskan beberapa temuan penting mengenai nongkrong di kafe atau restoran yang dilakukan mahasiswa. Hasil penelitian menyebutkan bahwa mahasiswa Kota Surabaya menghabiskan waktu nongkrong 2-4 kali dalam seminggu di kafe dan restoran mewah. Budaya nongkrong di kalangan pelajar Kota Surabaya terlihat dari rangkaian sandiwara dramatis yang ditampilkan di atas panggung di depan media sosial. Serangkaian sandiwara dalam bentuk postingan media sosial dilakukan untuk mengaktualisasikan diri, merepresentasikan kemewahan, meningkatkan gengsi, dan mengikuti tren masa kini.Students in Surabaya hang out in cafes and restaurants not only to consume the products offered but also to form meanings and symbols that interpret their social identity. This research explains hanging out from Erving Goffman's Dramaturgical perspective. By conducting interviews involving students in Surabaya, the research formulated several important findings regarding hanging out in cafes or restaurants by students. The results of the research state that Surabaya City students spend time hanging out 2-4 times a week in luxury cafes and restaurants. The culture of hanging out among Surabaya City students is seen as a series of dramatic plays performed on the stage in front of social media. A series of skits in the form of social media posts are carried out to actualize oneself, represent luxury, increase one's prestige and follow current trends.
Embedding Ethical Values in HR Practices: A Strategic Approach to Elevate Employee Engagement and Reduce Turnover Intention
Authors: Yadav Pooja , Srivastava Abhaya Ranjan
Published: September 2024

In the competitive landscape of private sector banks, the dual challenge of elevating employee engagement and reducing turnover intention has emerged as a critical focal point. This abstract provides a glimpse into the research exploring the profound impact of Human Resource (HR) practices in navigating these intertwined challenges. Through an investigation of ethical and social responsibility, diversity and inclusion, ethical leadership, employee wellness program, employee rewards and recognition, this research uncovers the important role played by HR practices in creating a workforce extremely engaged with the organization's goals and concurrently mitigating the intentions of employees to seek alternatives. The data was collected from the private banks situated in Jharkhand region. The study employed various tools like regression, correlation, confirmatory factor analysis etc. to study the relationship between dependent and independent variable. The findings of the study offer valuable insights for private sector banks seeking to enhance their organizational performance and stability, positioning HR strategies at the core of their success.
What kind of Marketing Data is needed for Artificial Intelligence Analysis? A Theoretical Approach
Authors: Ankita Raj
Published: September 2024

Purpose: The interfacing of enterprises with technological innovation and AI shows a clear path to growth and progress through job automation and increased productivity. However, there are management professionals who need an understanding of AI and the ways to upskill themselves to make use of it. The objective of this research is to provide insights into the relevance of the AI concept in marketing to people from non-technical backgrounds. With more conceptual knowledge, they will be capable of improving tasks in existing projects, planning for future ones, and making improved decisions with results from AI models.
Methodology: For this, published research papers, news articles, and books from authentic sources were studied.
Design: This paper introduces the concepts of AI and marketing, states the need for understanding AI by marketers, states the research methodology, and gives an in-depth understanding of the kind of data that marketers must provide to their data analyst colleagues, along with ways to collect them, followed by a discussion and conclusions.
Findings: This paper is a practical guide to the theory of AI and its usability in the marketing context. The findings are suitable for future researchers interested in AI and marketing, for developing different analytical approaches.
Originality/ Value: Since the future of AI is unknown to many, this paper provides guidance for the enrichment of human knowledge. It has two benefits. i) When employees are aware of the kind of data that they can use, they will feel empowered. ii) When customers know the kind of data that can be extracted from them, then they will safeguard themselves more.
Implementasi Supervisi Akademik Berbasis Digital
Authors: Qamaruzzaman Muhammad , Setiawan Endry , Hanifah Evy , Chairiyah Siti Sri , Warman Warman
Published: September 2024

Penelitian ini bertujuan untuk menggambarkan implementasi atau pelaksanaan supervise akademiki berbasis digital, dalam rangka peningkatan kinerja guru. Metode penelitian yang digunakan adalah metode kualitatif, dengan pendekatan studi literature. Analisis secara disriptif berdasarkan data dari referensi. Pada penelitian ini diambil 8 obyek jurnal terkait dengan penilaian supervise akademik berbasis digital. Hasil penelitian menunjukkan implementasi supervise akademik berbasis digital dapat memberikan efisiensi dan efektivitas pelaksanaan supervise, karena akan mempermudah dan merekam data secara tepat. Selain itu, pelaksanaan supervise ini meningkatkan kemampuan guru dalam literasi, dan meningkatkan kemampuan guru untuk mengeksplore kemampuannya dalam penggunaan software atau perangkat lunak guna mendukung pelaksanaan supervise akademiki tersebut.
Peer Review of “Exploring the Accuracy of Ab Initio Prediction Methods for Viral Pseudoknotted RNA Structures (Preprint)” (Preprint)
Authors: Saderi Daniela , Nagesh Vaishnavi , Mahmoud Randa Salah Gomaa , Olatoye Toba , Arogundade Femi Qudus
Published: September 2024

UNSTRUCTURED
Impact of Stressful Life Events on Preventive Colon Cancer Screening Adherence: Large Language Model Approach (Preprint)
Authors: Scherbakov Dmitry , Heider Paul M. , Wehbe Ramsey , Alekseyenko Alexander V. , Lenert Leslie A. , Obeid Jihad S.
Published: September 2024

BACKGROUND

Increase in early onset colorectal cancer makes adherence to screening a significant public health concern with various social determinants playing a crucial role in its incidence, diagnosis, treatment, and outcomes. Stressful life events, such as divorce, marriage, or sudden loss of job, have a unique position among the social determinants of health.

OBJECTIVE

We applied a large language model (LLM) to social history sections of clinical notes in the health records database of the Medical University of South Carolina to extract recent stressful life events and assess their impact on colorectal cancer screening adherence.

METHODS

We used pattern-matching regular expressions to detect a possible signal in social histories and ran LLM four times on each social history to achieve self-consistency and then used logistic regression to estimate the impact of life events on the probability of having an EHR code related to colorectal cancer screening.

RESULTS

The LLM detected 380 patients with one or more stressful life events and 5,344 patients with no life events. The events with the most negative impact on screening were arrest or incarceration (OR 0.26 95% CI 0.08-0.88), becoming homeless (OR 0.18 95% CI 0.02-1.38), separation from spouse or partner (OR 0.32 95% CI 0.07-1.42), getting married or starting to live with a partner (OR 0.59 95% CI 0.22-1.63). Death of somebody close to the patient, but not spouse increased the chance of screening (OR 1.21 95% CI 0.71-2.05).

CONCLUSIONS

Our findings suggest that stressful life events might have an unexpected impact on screening, with some events, such as experiencing somebody’s death, acting as facilitators to screening. The future work should include expanding the list of stressful life events by including a validated scale of stressful life events for patients from historically marginalized groups.
Online safety when considering self-harm and suicide-related content: Perspectives of young people, policymakers, and social media companies (Preprint)
Authors: La Sala Louise , Sabo Amanda , Michail Maria , Thorn Pinar , Lamblin Michelle , Brown Vivienne , Robinson Jo
Published: September 2024

BACKGROUND

Young people are disproportionately impacted by self-harm and suicide, and concerns exist regarding the role of social media and exposure to unsafe content. Governments and social media companies have taken various approaches to address online safety for young people when it comes to self-harm and suicide, however, little is known about whether key stakeholders believe current approaches are fit-for-purpose.

OBJECTIVE

The present study aimed to explore the perceived challenges and views regarding young people communicating on social media about self-harm and suicide, as well as what more social media companies and governments could be doing to keep young people safe online.

METHODS

This qualitative study involved six focus groups with Australian young people aged 12-25 years (n = 7), Australian policymakers (n = 14), and professionals from international social media companies (n = 7). Framework analysis was used to summarize and chart the data for each stakeholder group.

RESULTS

Three primary themes and six sub-themes are presented and speak to the challenges and concerns for young people communicating online about self-harm and suicide, the roles and responsibilities for online safety and suicide prevention, and the use of social media safety features and policies.

CONCLUSIONS

Findings highlight the importance of cross-industry collaborations and consideration of social media in future suicide prevention solutions intended to support young people.
Spatial analysis of under five years pneumonia incidence in DIY Province 2020
Authors: Kusumadewi Ni Nengah Sri , Makful Martya Rahmaniati , Meutia Liza
Published: September 2024

Purpose: Globally, pneumonia is a major cause of morbidity and mortality, as the largest burden of disease and death in developing countries. In 2018, more than 19,000 children under five died from pneumonia. The Under-five Mortality Rate (AKBa) reflects the social, economic, and environmental conditions in which children live and maintain their health. WHO issued an integrated global action to prevent and control the incidence of pneumonia and diarrhea (GAPPD). Yogyakarta is in the second position with the highest prevalence of pneumonia under five (3.7%). To carry out a more focused pneumonia prevention program, spatial pattern analysis is needed both globally and locally, this study examines whether there is a global and local spatial correlation in the number of pneumonia cases under five years in Daerah Istimewa Yogyakarta (DIY) in 2020.
Methods: This ecological study uses aggregated data at the sub-district level. DIY Province has 78 sub-districts that serve as the unit of analysis.
Results: The global spatial autocorrelation test on the number of cases of toddler pneumonia in DIY is significantly positive. High-high areas include the sub-districts of Semin, Ponjong, Rongkop, Semanu, Karangmojo, Wonosari, Playen, Paliyan, Saptosari and Panggang. Hot spots were found in the southeastern region. A closer look at the sub-districts in the hotspot area, all from Gunung Kidul Regency, shows that specific interventions targeting these areas must be strengthened, regional health planning and resource allocation.
Conclusion: A cluster correlation (clustering) exists spatially with the number of toddler pneumonia in the DIY. Locally, it can be seen that the hot spots (high-high) and low-high districts are found in one district. So it is a priority area that needs comprehensive handling but with a different emphasis according to the characteristics of each sub-district in one district.
Securing RFID in IoT Networks With Lightweight AES and ECDH Cryptography Approach
Authors: Robby Kurniawan Harahap  , Alief Vickry Thaha Maulidzart  , Antonius Irianto Sukowati  , Dyah Nur’ainingsih  , Widyastuti  , Desy Kristyawati
Published: September 2024

Radio frequency identification (RFID) technology integrated into the Internet of things (IoT) networks often poses security and privacy concerns due to its attack vulnerability. This research proposed a lightweight cryptographic model tailored for implementation in resource-constrained environments. The objective is to address security challenges while accommodating limited memory, power, and size requirements. A combined modified 126-bit Advanced Encryption Standard (AES) algorithm with a 256-bit elliptic curve Diffie-Hellman (ECDH) cryptographic key was utilized to develop lightweight cryptography for securing RFID data. The implementation used the Python programming language in Jupyter Notebook, with RFID operating at 13.56 Mhz. The methodology involved retrieving RFID data through additional programs and equalizing ECDH keys for encryption and decryption. Encryption and decryption testing demonstrated a high success rate, achieving an accuracy of 99.9%. The first encryption attempt required 85.125 ms, with the second attempt completed faster at 65.95 ms, showcasing improved efficiency. File encryption sizes averaged 29.875 bytes for the initial attempt and 30.1 bytes for the subsequent one. This research was limited to algorithm evaluation and had not been implemented in hardware. However, the proposed hybrid cryptography offers significant benefits for maintaining the confidentiality of RFID data within IoT environments. Rapid, efficient, and compact encryption of unique identifier (UID) data ensures enhanced security, thereby addressing critical concerns associated with RFID-enabled IoT networks.
How to Obtain Valid Generalized Modal Syllogisms from Valid Generalized Syllogisms
Authors: Xu Jing , Zhang Xiaojun
Published: September 2024

Making full use of the truth value definitions of sentences with quantification, possible world semantics and/or fuzzy logic, one can prove the validity of generalized modal syllogisms. This paper shows that the proof of the validity of a generalized modal syllogism can be transformed into that of its corresponding generalized syllogism, and that the generalized syllogism obtained by removing all modalities in any valid generalized modal syllogism is still valid. Therefore, the simplest way to screen out valid generalized modal syllogisms is to add modalities to valid generalized syllogisms, and then to delete all invalid syllogisms by means of the basic rules with which valid generalized modal syllogisms should meet. And then the remainders are valid. This paper illustrates how to obtain 12 valid generalized modal syllogisms by adding necessary modalities and/or possible modalities to any valid generalized syllogism. The two kinds of syllogisms discussed in this paper are composed of sentences with quantification which is the largest number of sentences in natural language. Hence, this innovative research can provide theoretical support for linguistics, logic, artificial intelligence, and among other fields.
NANOCREAM FOUNDATION FORMULATION LOADED WITH ETHYL ACETATE FRACTION FROM MELASTOMA MALABATHRICUM l.
Authors: PRATIWI LIZA , SARI RAFIKA , APRIDAMAYANTI PRATIWI
Published: September 2024

Objective: This study aimed to create a nanocream formula of the ethyl acetate fraction of Melastoma malabathricum using Design-Expert software. The objective was to obtain an optimal nanocream formula, analyze its characteristics, test its real-time stability, and measure its free radical scavenging ability using the DPPH method.
Methods: The study began by manufacturing 70% ethanol extract from Melastoma malabathricum leaves and fractionating it with ethyl acetate to obtain the desired fraction. The fraction was then used to create a nanocream using cetyl alcohol, liquid paraffin, and propylene glycol in a ratio of 5:5:15. The optimal formula was tested for real-time stability and antioxidant effectiveness using the DPPH method.
Results: Based on the results of the study, the optimal formula of the nanocream foundation preparation of the ethyl acetate fraction of Melastoma malabathricum was a combination of cetyl alcohol, liquid paraffin and propylene glycol in a ratio of 5:5:15. The results showed that the optimal nanocream formula had a pH value of 6.1±0.36, a spreadability of 6.57 cm ±0.06, and an adhesion of 22.20 minute±0.03. The particle size was determined to be 47 nm±0.78. The optimal formula also showed practical free radical scavenging ability, with an IC50 value of 556,29±0,155. The nanocream was stable for 28 d of real-time testing, and the honey extract remained stable during freeze-thaw.
Conclusion: In conclusion, using the design-expert software, the study successfully created a nanocream formula from the ethyl acetate fraction of Melastoma malabathricum (NFMM). The resulting nanocream had physical characteristics that met the requirements for pH, spreadability, adhesion, and particle size. It was stable for 28 d of real-time testing and showed antioxidant activity when tested with the DPPH method.
DRUG EXCIPIENT ADSORPTION TECHNIQUE FOR THE PREPARATION OF LOW-DOSE TABLETING
Authors: SHANMUKHAN NIKHITHA K. , G. RAMYA , RADHAKRISHNAN ARUN
Published: September 2024

Objective: This study aimed to improve drug mixability and drug uniformity in personalized medicine low-dose tablet by developing a stable, easily mixable, drug-adsorbed filler. Methods: The research involved adsorbing drug onto filler by using three solvents and drug-to-excipient ratios of 1:50 and 1:75. The drug adsorbed fillers, were analyzed for drug content uniformity and flow properties, which are crucial for accurate dosing and manufacturing of low dose tablet. Results: Formulations T1, T2 and T3 showed similar flow properties, including bulk and tapped densities, Carr's indices, and Hausner ratios. T1 had better flowability with a lower angle of repose (23.97 degrees) compared to T2 (35.42 degrees), T3 (49 degrees), and T4 (39 degrees) and it also had higher drug uniformity (99.89%, 99.54%, 97.12%, 96.83%). Tablet evaluations of TS1, TS2, TS3 and TS4 met standard criteria for weight variation, friability, and hardness criteria, with TS1 showing a quicker disintegration time (2:58 min), indicating faster dissolution and potentially better bioavailability. Dissolution tests showed both exceeded 85% drug release within 30 min, with TS1 achieving a higher release (99.98), suggesting more efficient drug release. Conclusion: The drug-adsorbed filler premix technique effectively ensures drug content uniformity and improves low-dose drug mixing, contributing to the development of safe, efficient low-dose pharmaceuticals.
INHIBITION ACTIVITY OF LIQUID SMOKE COCOS NUCIFERA L. ON DPP-IV AND AGE-RAGE IN SILICO AND IN VITRO: ANTIDIABETIC AND ANTI-INFLAMMATORY ACTIVITY
Authors: MASFRIA  , LUCIDA HENNY , ATIFAH YUSI , SYAHPUTRA HAFID , SIHOMBING HANNA MURTI
Published: September 2024

Objective: The research aims to predict the inhibitory activity of liquid smoke compounds from coconut shells (Cocos nucifera L.) In silico and to determine the activity on reduction of glucose levels by the Nelson-Somogyi method and anti-inflammatory effect on the inhibition of protein denaturation in vitro.
Methods: This research used biological activity prediction, physicochemical prediction, molecular docking, and in vitro analysis using a UV-Vis spectrophotometer.
Results: There were 13 liquid smoke compounds from Gas Chromatography-Mass Spectrometry (GCMS) result and shows that every liquid smoke compound has wound-healing activity and complies with Lipinski's Rule of Five. Urea did not fulfil the AMES Toxicity parameter, and four compounds had the highest level of toxicity. From the docking results, the binding affinity score between liquid smoke compounds and DPP4 inhibitors ranged from-5.3 to-3.0. Meanwhile, the Advance Glycation End Products Receptors (AGE-RAGE) receptor went from -2.5 to -1.5. 13 compounds had inhibitory activity on Dipeptidyl Peptidase 4 (DPP4); meanwhile, there are 12 compounds on AGE-RAGE In silico. The activity of liquid smoke antidiabetic at 10 µg/ml was 31.26%, while quercetin was 46.36%. In the anti-inflammatory analysis, the IC50 value of the liquid smoke compound was 22.41 µg/ml, while diclofenac sodium was 0.42 µg/ml.
Conclusion: The result shows that 13 liquid smoke compounds had inhibitory activity on DPP4, while 12 compounds on AGE-RAGE were In silico. The in vitro results found that liquid smoke compounds have glucose-reducing activity, and from the IC50 value, it is concluded that both compounds have potent anti-inflammatory activity.
FORMULATION AND IN VIVO EVALUATION OF NANOEMULGEL-CONTAINING COCOA POD HUSK (THEOBROMA CACAO L.) EXTRACT AS TOPICAL ORAL PREPARATION
Authors: RAHAYU YANI CORVIANINDYA , SETIAWATIE ERNIE MADURATNA , RAHAYU RETNO PUDJI , KUSUMAWARDANI BANUN , ULFA NINIK MAS
Published: September 2024

Objective: Cocoa pod husk (Theobroma cacao L.) extract was applied to enhance bioavailability and drug effects due to antibacterial, antioxidant and anti-inflamation agents. Recent years have seen significant development of nanomedicine in non-invasive therapy of oral infection. The aim of this study was to develop the formula of nanoemulgel of Cocoa Pod Husk (CPH) extract for topical oral therapy compared its stability and evaluation in gingivitis rats with gels preparations on different gelling agents. Methods: The topical oral preparation were made in 4 formulations: F1 (CPH gel with gelling agent Sodium Carboxy Methyl Cellulose (Na-CMC) 3%); F2 (CPH gel with gelling agent Carbomer 1%); F3 (CPH nanoemulgel with gelling agent Na-CMC 3%); and F4 (CPH nanoemulgel with gelling agent Carbomer 1%. The physical characterization test of preparations were evaluated the pH, homogeneity, viscosity, spreadability and adhesion test. In vivo evaluation of gingivitis rats were observed using histological analysis of the fibroblast number and gingival collagen density in experimental Wistar rats by Hematoxylin eosin and Masson trichrome staining.Results: Four formulation (F1-F4) showed good stability in pH, viscosity, spreadability and adhesivity (p<0.05). The observation for 7 d after gel application to gingivitis rats, showed that the number of fibroblast and collagen density increasing in the treatment group compared to the control group (p<0.001). In the LSD test, F3 and F4 indicated the highest increase, however no significantly different (p>0.05).Conclusion: Nanoemulgel with Na-CMC as gelling agent potential to be used as an effective carrier for the active ingredients of CPH extract.
DEVELOPMENT OF NANOSPONGES-BASED TOPICAL FORMULATION FOR THE EFFECTIVE DELIVERY OF SELECTED ANTIFUNGAL DRUG
Authors: ANUSHA RUDROJU , M. MOTHILAL
Published: September 2024

Objective: To increase luliconazole's therapeutic impact, distribution, and preservation, this project is aimed to prepare cyclodextrin-based nanosponge gel and test its topical skin administration.
Methods: The convection heating method produced cyclodextrin-diphenylcarbonate nanosponges, which later loaded with luliconazole by freeze-drying. Response Surface Methodology (RSM) was used to examine the association between procedure parameters and quality variables. Pilot study findings were analyzed using Analysis of variance. Key technique factors affect quality metrics in contour, RSM, and perturbation graphs.
Results: The mean medication payload was 42.19±1.45 mg of luliconazole/g of lyophilized powder. The remarkable encapsulation efficiency of luliconazole (90.12±0.92%) supports an inclusion complex. Laser light scattering evaluation of luliconazole-loaded-nanosponges shows an unimodal and narrow particle size distribution of 60-73 nm. Drug encapsulation does not change a typical nanosponge's spherical form, according to microscopic investigations. Physico-chemical characterized verified the nanosponge-luliconazole inclusion complex. The complex release is faster than pure medication in vitro. Pure luliconazole dissolves 12% in 12 h, whereas nanosponge encapsulated medicine is absorbed faster and better. After 12 h, nanosponge formulations released 93-95% luliconazole. A model carbopol gel formulation with nanosponge formulations examined skin permeability, antifungal effectiveness, and stability. In 12 h skin permeation trials, nanosponge-encapsulated luliconazole leaked slowly across rat skin.
Conclusion: The slow drug release, greater skin penetration, and superior storage stability of the gel formulation based on cyclodextrin nanosponges of luliconazole imply that it has great potential as a topical delivery system.
DEVELOPMENT OF GUGGULSTERONE-LOADED PHYTOSOMES: A QUALITY BY DESIGN-BASED CHARACTERIZATION AND OPTIMIZATION STUDIES
Authors: DUDEKULA JAMAL BASHA , KOILPILLAI JEBASTIN , NARAYANASAMY DAMODHARAN
Published: September 2024

Objective: The primary objective of this study was to enhance drug delivery efficiency through the design and optimization of guggulsterone-pyrosomes, employing a 3-factor, 3-level box-behnken design. Methods: The methodology involved a solvent evaporation technique utilizing guggulsterone and soy lecithin, with a systematic variation and optimization of critical factors such as soy lecithin and guggulsterone concentration, alongside temperature adjustments to refine the phytosome formulations. The characterizations of these formulations were extensive, with a particular emphasis on key quality attributes, notably percentage entrapment efficacy and drug release. Results: The optimized guggulsterone-pyrosomes demonstrated impressive outcomes, showcasing a remarkable entrapment efficiency of 92.64% and a noteworthy drug release rate of 91.69% at 24 h. These formulations displayed heightened viability in selected cell lines, exhibiting cellular toxic c concentrations ranging from 253.39 to 330.44 µg/ml. Moreover, they exhibited stability under stressed conditions from a physicochemical perspective. The particle size was measured at 137.8 nm, with a zeta potential of-25.3 mV. Conclusion: Significantly, the extended drug release from guggulsterone-pyrosomes adhered to first-order kinetics with Fickian diffusion. In summary, this study underscores the efficacy of the box-behnken design in crafting optimized guggulsterone-pyrosomes, showcasing their potential as promising drug delivery carriers. The enhanced drug delivery platform exhibits significant promise in amplifying antihyperlipidemic effects, attributed to the improved performance and stability of these innovative phytosomes
Explore how the authors of “The Bell Jar” and “King Lear” present the theme of madness
Authors: Allen Phoebe
Published: September 2024

The following paper will explore the literary and subsequent social significance of madness in literature, notably “The Bell Jar” and “King Lear” since their authors have both similarities and differences in their approaches and contexts surrounding this theme. This paper attempts to explore the how, what and why when it comes to both authors’ approaches to the theme of madness, delving into debates such as the power of social construction in literary media, and addressing timeless social disputes such as gender and age inequality. Ultimately this paper not only explores how the authors of The Bell Jar” and “King Lear” present the theme of madness, but why, it’s still important to understand.
Forschungsorganisation und Forschungsstrategie an österreichischen Hochschulen am Beispiel der FH Technikum Wien
Authors:   FH Technikum Wien, Strähle Michael , Ahorner-Krenn Elke
Published: September 2024

In diesem Artikel werden die Entwicklung und Bedeutung von Forschungsstrategien an Hochschulen, insbesondere im Kontext des Umbruchs im Hochschulsystem seit den 1980er Jahren thematisiert. Anhand der FH Technikum Wien wird gezeigt, wie Forschungsstrategien als Instrument zur Fokussierung und Steuerung von Forschungsaktivitäten dienen und welche Herausforderungen und Chancen sich daraus für die Fachhochschulen ergeben. Besonderes Augenmerk liegt auf der Integration von Forschung und Lehre, der Einwerbung von Drittmitteln und der Schaffung nachhaltiger Strukturen für Forschung und Entwicklung.
La ballena gris y su avistamiento en México
Authors: García Castañeda Omar
Published: September 2024

Esta infografía surge de la preocupación por el bienestar de la ballena gris y su entorno, debido a la presión por parte de los turistas por tocar u observar las ballenas de cerca. Aquí, se explica un poco acerca de la ballena gris, así como de la nom-131-semarnat-2010, que regula los avistamientos de ballenas en México.
Digital Marketing Strategy, Marketing Communication, and Service Quality: Their Impact on Wardah Cosmetics Consumer Satisfaction in The Age Range of 18-40 Years
Authors: Arfah Lita
Published: September 2024

The aim of this study is to see how the satisfaction of Wardah cosmetics customers in Pekanbaru, who are between the ages of 18 and 40, is influenced by digital marketing strategies, marketing communications, and quality of service. Using the purposive sampling method, 238 people who used Wardah products and had access to digital media were selected. Independent variables determine consumer satisfaction, which is measured through the questionnaires used for data collection. Data analysis is carried out using Pearson correlation methods to evaluate the strength of the relationship between independent variables and customer satisfaction. The results of the research showed that digital marketing strategies and consumer satisfaction had a significant positive correlation with a correlative coefficient of 0.65 (p = 0.001), marketing communications also had a positive corelation with the correlational factor of 0.58 (p= 0.005), and the quality of service has a positive Correlation of 0.72 (p_0.005). The study found that Wardah cosmetics customers in Pekanbaru, especially customers between the ages of 18 and 40 years, were very satisfied with digital marketing strategy, marketing communication, and service quality. This conclusion provides practical implications for companies to create more effective marketing and service strategies to increase customer loyalty and satisfaction.
The Legal Status of Cryptocurrency and Its Implications for Money Laundering in Indonesia
Authors: Alhakim Abdurrakhman , Tantimin Tantimin
Published: September 2024

Decentralized technologies such as blockchain facilitate secure and anonymous transactions, heralding a new era of financial innovation. However, the advent of cryptocurrencies has also posed significant challenges, especially in the realm of preventing money laundering practices. In Indonesia, individuals have exploited these systems for illicit money laundering from fraudulent schemes. Therefore, this study aimed to critically analyze the effectiveness of current regulatory frameworks and propose improved approaches to mitigate money laundering risks associated with cryptocurrency. Indonesia expects to shift its legal perspective due to the substantial threats posed by attempting to regulate a volatile financial system. This study employed normative legal research methods. The findings suggest that recognizing cryptocurrency as a legal tender could advance the agenda of addressing money laundering as a critical threat to financial stability and national security. This would significantly enhance the regulatory framework and ensure the financial system's integrity amidst evolving threats.
Kualitas Hamburger dengan Patty Berbahan Wortel
Authors: Pujana Ida Bagus Oka , Febianti
Published: September 2024

Penelitian eksperimen ini mengambil judul Kualitas Hamburger Dengan Patty Berbahan Wortel. Tujuan penelitian ini yakni guna memajukan produk hamburger yaitu dengan memanfaatkan wortel sebagai bahan dasar patty. Temuan akhir yang diinginkan yakni patty dengan bahan dasar wortel berkualitas dilihat dari aspek warna, rasa, aroma, tekstur, serta masa daya tahan. Penelitian ini dilakukan sendiri oleh penulis dengan mencatatkan nilai dari temuan pengamatan yang telah dilakukan. Hasil dari penelitian ini difoto agar dapat memperoleh hasil yang lebih jelas. Hasil ekserimen berupa patty berbahan sayuran akan di uji dengan dua model pengujian yaitu sebagai berikut: Hasil yang diperoleh dari pembuatan patty wortel dengan menggunakan analisis organolaptik akan diberikan kepada 30 orang panelis dengan tes organolaptik guna mencari tahu mutu patty dengan bahan dasar wortel di tinjau dari aspek rasa, teksur, warna, serta aroma. Untuk pengujian daya tahan dari patty dilaksanakan melalui observasi mengetahui mutu patty wortel. Biaya yang diperlukan untuk memproduksi 1 bungkus hamburger dengan patty berbahan dasar wortel per 100 gram adalah Rp 16.625.
 
This experimental research took the title Hamburger Quality with Carrot-based Patty. This research’s aim is to develop hamburger products by utilizing carrots as the basic ingredient of patty. The expected end result is a quality carrot-based patty in terms of taste, color, aroma, texture and durability. This research was conducted by the author himself by recording the score or value of the experimental results that have been carried out. The results of this study were photographed in order to obtain clearer results. The results of the experiment in the form of vegetable-based patties will be tested with two testing models, namely as follows: The results obtained from making carrot patty using organolaptic analysis will be given to 30 panelists with organolaptic tests to determine the quality of carrot-based patty in terms of texture, taste, color, also aroma. The durability test of the patty is carried out by observing the quality of the carrot patty. The cost required to produce 1 pack of hamburger with carrot-based patty per 100 grams is IDR 16,625.
Analisis Strategi Alternatif Bisnis berdasarkan Analisa SWOT
Authors: Natalya K. Denyk Anissa , Sudarmawan I Wayan Eka
Published: September 2024

Penelitian ini mangulas tentang Analisis Strategi Alternatif Bisnis berdasarkan Analisa SWOT Studi Permasalahan pada Vue Beach Club Bali. Tujuan penelitian ini ialah untuk menganalisis faktor IFAS dan EFAS dengan memakai analisis SWOT di Vue Beach Club Bali. Jenis data yang digunakan ialah data kualitatif dan kuantitatif. Metode analisis data yang digunakan ialah metode deskriptif kualitatif, analisis SWOT, IFAS, EFAS, kuadran, dan matriks SWOT. Bersumber pada hasil dari analisis SWOT, hasil dari analisis IFAS dan EFAS di Vue Beach Club Bali merupakan terletak pada koordinat X= 0.77 serta koordinat Y= 1.30 ataupun terletak pada kuadran I (Agresif) yang artinya Vue Beach Club Bali memiliki kekuatan internal yang bisa memanfaatkan peluang eksternal sehingga perihal itu bisa mengetahui strategi bisnis untuk dapat menyaingi para pesaing di sekitar Vue Beach Club Bali. Sehingga strategi bisnis yang mampu dilakukan oleh Vue Beach Club Bali dalam melawan pesaing di sekitar yaitu dengan mengatur ulang strategi, maupun mengganti strategi yang lama dengan yang baru.
 
The objective of this research is to analyze IFAS and EFAS factors using SWOT analysis at Vue Beach Club Bali. The data types used are qualitative and quantitative data. The methods used for data analysis are Qualitative Descriptive Methods, SWOT Analysis, IFAS, EFAS, Quadrant, and SWOT Matrix. Based on the results of SWOT analyses, the results from IFAS & EFAS analysis at the Vue beach club Bali are located at coordinates X=0.77 and Y=1.30 or located on Quadran I (Agressive) which means that Vue strand club Bali has internal powers that can take advantage of external opportunities so that it can know business strategies to compete with competitors around the Vue Beach Club. So the business strategy carried out by Vue Bali beach club is capable of competing around, i.e. to regulate, replace old strategies with new strategies.
Kualitas Wine Berbahan Dasar Buah Naga
Authors: Juniarta I Kadek Wahyu , Sudiarta I Nyoman
Published: September 2024

Hasil pertanian Indonesia sangat beragam, dan salah satu tanaman pangan yang semakin populer dan banyak dinikmati saat ini adalah buah naga. Buah naga merupakan buah dari berbagai kaktus dari genus Pitaya dan genus Selenium. Buah naga merah segar memiliki kandungan air yang tinggi sehingga tidak dapat disimpan dalam waktu lama sehingga memerlukan pengolahan lebih lanjut. Wine merupakan minuman yang terbuat dari sari buah yang tinggi gula dan difermentasi dalam kondisi anaerobik dengan bantuan mikroorganisme ragi. Buah naga merah mempunyai potensi besar sebagai minuman beralkohol seperti wine karena warna sari merahnya yang menarik. Metodologi penelitian yang digunakan dalam penelitian ini adalah eksperimental dan meliputi konversi buah naga merah menjadi wine, dilanjutkan dengan evaluasi sensorik oleh 30 anggota panel, pengujian umur simpan dan analisis biaya biaya yang dikeluarkan selama produksi wine buah naga. Hasil penelitian berdasarkan masukan dari 30 panelis menunjukkan bahwa wine buah naga layak untuk diminum dan memiliki umur simpan kurang lebih 1 bulan 2 minggu bila disimpan dalam kondisi yang sesuai.   
 
Indonesia's agricultural products are very diverse, and one of the food crops that is increasingly popular and widely enjoyed today is dragon fruit. Dragon fruit is the fruit of various cacti from the Pitaya genus and the Selenium genus. Fresh red dragon fruit has a high water content so it cannot be stored for a long time and requires further processing. Wine is a drink made from fruit juice which is high in sugar and fermented under anaerobic conditions with the help of yeast microorganisms. Red dragon fruit has great potential as an alcoholic drink such as wine because of the attractive red color of its juice. The research methodology used in this research is experimental and includes the conversion of red dragon fruit into wine, followed by sensory evaluation by 30 panel members, shelf life testing and cost analysis of the costs incurred during the production of dragon fruit wine. The research results based on input from 30 panelists showed that dragon fruit wine is suitable for drinking and has a shelf life of approximately 1 month 2 weeks when stored in appropriate conditions.