bluuebunny/crossref_metadata_2025 huggingface dataset:
Polymerase Theta-mediated DNA End-Joining Repair in the Maintenance of Genome Stability
Authors: Yan Xiangyu
Published: January 2025

The DNA double-strand break (DSB) always occurs within genome. The pathways that repair the DSB are essential in keeping cell viability. This review will focus on the recent understanding of TMEJ, especially two key protein factors involved in the TMEJ repair pathway2, DNA polymerase theta (Polθ) and DNA polymerase delta (Polδ), and discuss the potential mechanism of choosing repair pathways when there is a DNA Double Strand Break. We dissect TMEJ's unique mechanism of action, including recognition of DNA ends, microhomology search, end pairing, and DNA synthesis, by focusing on the enzyme Polθ as the central player to understand the repair pathway choice. We also discuss how BRCA-mutated cancer uses the TMEJ repair pathway to facilitate breast cancer cells' growth3. This review aims to provide a comprehensive overview of TMEJ's cellular functions, regulatory mechanisms, and pivotal role in BRCA-mutated breast cancer.
Fluorescent Biosensors in the Detection of Mycotoxins: Working Principles and Applications
Authors: Zhou Xinyu
Published: January 2025

Due to their superior sensitivity and specificity, fluorescent biosensors have become highly effective tools for detecting mycotoxins. This thesis delves into the fundamental principles, material choices, and technological advancements that underpin these biosensors. Special attention is given to the role of aptamer technology. It involves synthetic nucleic acids which is known for the exceptional specificity and binding affinity. The aptamers significantly enhance biosensor performance by offering greater design versatility and more robust target recognition than conventional antibodies. Incorporating quantum dots and fluorescent dyes as signal labels further enhances the optical capabilities of these biosensors, enabling precise multicolour imaging and the ability to conduct multiplexed detection. This study underscores the essential function of fluorescent biosensors in tackling food safety challenges, particularly those bring about by mycotoxins. These sensors provide rapid and accurate detection methods for analysing complex sample matrices. The research findings presented in this work offer valuable insights into optimizing biosensor technology. This work would contribute to the advancement in food safety, environmental monitoring, and medical diagnostics. By deepening the understanding of these technologies, this work sets the stage for future innovations to protect public health further and enhance safety measures.
Imaginations of Feasibility, Method of Production and Benefits of Oral MMR Vaccine
Authors: Tang Haoyang
Published: January 2025

Measles, mumps and rubella are acute infectious diseases caused by viral infections in children and caused great harm before the use of vaccines. The Measles, Mumps and Rubella (MMR) oral vaccine indicates a breakthrough in the fight against three infectious diseases which are measles, mumps and rubella. Unlike the traditional injectable MMR vaccine. This oral vaccine does not require an injection, and it can improve patient acceptance. The purpose of this paper is to provide a comprehensive study of the development, efficacy and safety of the oral MMR vaccine and compare it with the traditional injectable vaccine. It will emphasize the benefits of oral vaccines, such as reduced needle-related fears and increased accessibility, which are particularly beneficial in resource-limited settings where needle vaccination may be impractical. In addition, this paper will discuss the challenges of maintaining vaccine stability, dosage accuracy, vaccine efficacy and safety. Through these analyses, this paper seeks to determine whether oral MMR vaccine can be a viable alternative to global immunization efforts.
Exploring Lecanemab: Mechanisms, Efficacy, and Clinical Implications in Alzheimer's Disease Management
Authors: He Ziming
Published: January 2025

Lecanemab, with accelerated approval from the FDA, becomes a notable and promising drug to fight against Alzheimer's disease (AD). As one monoclonal antibody, it is reported that lecanemab can reduce cognitive decline caused by AD by reducing amyloid-beta in patients. However, some concerns, uncertainties and limitations of Lecanemab in clinical trials have also been brought out. This study analyses the existing methods to cure AD and researches in clinical phases of lecanemab and relevant detailed information. This article aims to provide a relevant view of key aspects of lecanemab’s performance, including its mechanisms, effects, safety, limitations and tips. Thus, this study shows an updated summary for those who want to be exposed to the current situations of applications of Lecanemab. The nature of AD remains complex to us nowadays, so further fundamental research concerning the causes and mechanisms of AD. For those drugs targeting AD, many aspects involving itself and its usage still need to be investigated.
Effect of Gamma Irradiation on Nutritional Quality and shelf life of Groundnut Species Produced in Benue State Nigeria
Authors: Akaagerger N. B. , Ochokwunu P. E.
Published: January 2025

Groundnut is a perishable crop and is subject to quality losses during storage through insect pests, rodent infestation and fungal development. Gamma (γ) irradiation has emerged as  a promising technique which could effectively be used for disinfestations of stored food products therefore presenting alternative to chemical preservatives. This research investigated the effect of gamma irradiation on  nutritional quality and shelf life of groundnut species produced in Benue State Nigeria. The seeds of Bernarda 1 groundnut (BE1G), Local groundnut (LOG) species were irradiated at varying doses (0, 200, 300, 400 and 500 Gy) using Cobalt-60 Gamma Irradiator. The irradiated and non-irradiated samples were each divided into two portions. The first portion was used for proximate analysis while the second was stored for a period of four months under the same ambient temperature and conditions in a polythene bags and its percentage weight loss were determined. Proximate analysis revealed no significance difference at (p≥0.01) in moisture, protein, crude fibre and fats composition of BE1G species between non irradiated and irradiated samples, however a significant variation (p≤0.01) was observed in its ash and carbohydrate across 200 Gy, 300 Gy and 400 Gy. The result also revealed no significant difference in the proximate composition of LOG species for 400 Gy and 500 Gy doses. After four months storage, percentage weight loss analysis indicated a significant difference between irradiated and control seeds of samples. The 500 Gy dose exhibited the least weight loss in the samples. These findings suggest 500 Gy as gamma irradiation dose for BE1G and LOG, highlighting the optimal effective doses for their preservation.
Analisis Rasio Keuangan Perusahaan Food and Beverage yang Tercatat di Bursa Efek Indonesia Periode 2019-2023
Authors: Narulita Friska Dhea , Soraya Bunga , Baderi Rahmawati Nur , Hidayati Cholis
Published: January 2025

The purpose of this research is to evaluate the financial performance of the food industry, namely PT Nippon Indosari Corpindo Tbk, PT Mayora Indah Tbk, and PT Indofood CBP Sukses Makmur Tbk using financial ratio evaluation from 2019 to 2023. The method applied is a descriptive quantitative approach by reviewing the company's financial statements within that period. The indicators analyzed are liquidity ratios, activity ratios, solvency ratios, and profitability ratios. The results of the study revealed that CBP has the best performance in terms of liquidity, while for the activity ratio, the company shows optimal effectiveness in managing receivables. In terms of solvency, Nippon Indosari Tbk recorded a lower debt-to-asset ratio than other companies. Meanwhile, in terms of profitability, CBP recorded the highest net profit margin, showing significant efficiency in managing operating costs.
Hambatan dan Peluang Efektivitas Alternative Dispute Resolution (ADR) dalam Penyelesaian Sengketa Bisnis di Indonesia Berdasarkan Undang-Undang Nomor 30 Tahun 1999
Authors: Frensiska Ardhiyaningrum  , Diana Setiawati
Published: January 2025

Business disputes are increasing in Indonesia along with the growth of economic relationships. Litigation is often perceived as time-consuming and costly, making Alternative Dispute Resolution (ADR) a more efficient and relationship-friendly alternative. This study aims to analyze the obstacles and opportunities in implementing ADR for business dispute resolution in Indonesia, based on the legal framework provided by Law Number 30 of 1999. The research employs a normative legal approach with descriptive analysis. Data were collected through literature reviews of legal regulations, academic literature, and journal articles. The findings reveal that although ADR holds significant potential for resolving business disputes efficiently and cost-effectively, its implementation faces several challenges. The primary obstacles include the lack of awareness among business actors about ADR's benefits, the perception that ADR lacks the legal authority compared to litigation, and the limited quality of mediators and arbitrators. The study also highlights the importance of enhancing the capacity of ADR practitioners through continuous training and educating business actors to build trust in this method. By addressing these challenges, ADR is expected to become the primary choice for resolving business disputes, fostering a conducive business environment, and supporting long-term economic growth in Indonesia.
Peran Hukum dalam Mendorong Pembangunan Ekonomi dan Menjamin Kesejahteraan Masyarakat : Perspektif Indonesia
Authors: Bahrul Ulum
Published: January 2025

This article examines the important role of law in promoting economic development and ensuring the well-being of people in Indonesia. It analyzes the legal framework that governs economic activities, focusing on principles and regulations that facilitate economic growth, protect rights, and promote social justice. This article explores the evolution of Indonesia's legal system in response to economic challenges and opportunities, highlighting key laws and policies that have shaped the nation's economic landscape. This includes an analysis of the constitutional foundations of Indonesia's economic system, with a special emphasis on Article 33 of the 1945 Constitution, which mandates a "people's economy" based on the principles of kinship, cooperative ownership, and state control over vital resources. Furthermore, this article discusses the challenges and prospects of using the law as a tool to achieve sustainable and inclusive economic development. It emphasizes the importance of legal certainty, regulatory efficiency, and the protection of public interests in fostering a conducive investment climate and promoting equitable economic growth. The article also discusses the role of law in addressing important issues such as environmental protection, labor rights, and consumer protection, highlighting the linkages between economic development and social welfare. By examining Indonesia's experience, this article contributes to a deeper understanding of the complex relationship between law and economic development in the context of developing countries.
Enhanced Diagnosis of Skin Cancer from Dermoscopic Images Using Alignment Optimized Convolutional Neural Networks and Grey Wolf Optimization
Authors: Mazhar Faheem , Aslam Naeem , Naeem Ahmad , Ahmad Haroon , Fuzail Muhammad , Imran Muhammad
Published: January 2025

Skin cancer (SC) is a highly serious kind of cancer that, if not addressed swiftly, might result in the patient’s demise. Early detection of this condition allows for more effective therapy and prevents disease development. Deep Learning (DL) approaches may be used as an effective and efficient tool for SC detection (SCD). Several DL-based algorithms for automated SCD have been reported. However, more efficient models are needed to improve accuracy. As a result, this paper introduces a new strategy for SCD based on Grey Wolf optimization (GWO) methodologies and CNN. The proposed methodology has four stages: preprocessing, segmentation, feature extraction, and classification. The proposed method utilizes a Convolutional Neural Network (CNN) to extract features from Regions of Interest (ROIs). CNN is employed for feature categorization, whereas the GWO approach enhances accuracy by refining edge detection and segmentation. This technique utilizes a probabilistic model to accelerate the convergence of the GWO algorithm. Employing the GWO model to optimize the structure and weight vectors of CNNs can enhance diagnostic accuracy by a minimum of 5%, based on evaluation outcomes. The application of the proposed strategy and its performance comparison with other methods indicate that the proposed method with GWO predicted SC with an average accuracy of 95.11% and without GWO an Accuracy of 92.66%, respectively, enhancing accuracy by a minimum of 2.5% when we train our model with GWO.
Investigation of the Effectiveness of Using Luffa Cylindrica to Reduce Water Consumption in Agriculture
Authors:   Birshrestha Noor Mohammad Public College, Dhaka, Bangladesh, Sikder Alman , Mumit Sayed Huzaifa
Published: January 2025

Background:
To achieve the Sustainable Development Goals: Zero Hunger, a stable and accessible water supply in agriculture is essential. The projected steady increase in population will contribute to a moderate increase in consumption, which in turn will require the development of technologies that increase soil productivity. With the increasing impact of global warming, droughts are becoming increasingly common in the northern region of Bangladesh. Notably, Bangladeshi farmers currently allocate about 37% of the total cost of rice production to irrigation.

Objectives:
The current study aims to overcome the problem of water shortage in agriculture, particularly in rice cultivation. It is expected that the use of biological sponge extracted from dried Luffa cylindrica will help retain water for its uptake by rice roots. That is, it is expected that by using Luffa cylindrica it will be possible to prevent or significantly reduce evapotranspiration and water seepage into the soil.

Methods:
This work is an experimental study on rice cultivation in soil with and without Luffa cylindrica. The study controlled the main factors contributing to water loss: evaporation and percolation, for the quantitative measurement of which different systems and methods were used. In addition, other extensive measurements related to irrigation were carried out and contribute to the understanding of the effectiveness/ineffectiveness of the studied approach to reducing water use.

Results:
A comparison of fields with and without Luffa cylindrica shows a marked contrast in water storage capacity. Initial observations indicate that integrating Luffa cylindrica into rice paddies improves water retention, thereby reducing losses due to evaporation and seepage. It was found that the irrigation frequency was above the optimum threshold to achieve the desired result. In addition, more water was required to fill the Luffa-containing field than the Luffa-containing field, as the dry Luffa cylindrica also had to be saturated. Despite these issues, the use of Luffa cylindrica resulted in water savings of 26.97%.

Conclusion:
improving soil moisture retention in rice paddies. By utilizing the fibrous structure of dry Luffa cylindrica, water losses due to evapotranspiration and seepage were significantly reduced, resulting in substantial water savings and reduced costs for farmers. The eco-friendliness and cost-effectiveness of Luffa cylindrica highlights its potential as a sustainable water management solution for agricultural practices. Its availability and ease of cultivation make it a viable option for farmers, with minimal investment required to implement the technique on a large scale.
Building DIY (Do-It-Yourself) Based Resilience: A Denpasar Kolektif Experience in the Pandemic Crisis
Authors: Wirawan I Gusti Made Arya Suta , Kangto Sanggar , Aminuddin M. Faishal , Putri L.G Saraswati
Published: January 2025

This study shows that the Covid-19 pandemic has not reduced the existence of collectivism and activism of a punk community in Denpasar City called Denpasar Kolektif (Denkol). The pandemic has not only led Denkol to build resilience for itself. With all the capital available, they are more active in building resilience for other social groups, especially those marginalized during the pandemic. Denkol does not only accommodate the catharsis of young people in expressing themselves during and after the pandemic. They also maximize the function of public spaces that the punk community has not filled during the pandemic. By prioritizing a qualitative phenomenological approach, the study shows that Denkol has built an inclusive habitus while running creative events during the pandemic. This inclusivity is essential not only for opening up critical space for the Balinese people towards various issues such as environmental issues, marginalization, mental health, and other things affected by the pandemic but also for self-criticism within the punk body itself, which is considered hegemonic. The increasingly inclusive fields also gave rise to decentralized activism, emphasizing that punk as a subculture opened space for creating plurality, fragmentation, and relativity within it.
Anesthesia for Patients With Burns: An Updated Review for Anesthesiologists and Nursing
Authors: Alwahbi Khalaf Naif , Alharbi Naif Lafi Salem , Almutairi Fahad Mohammed , Alshammari Muteb Alhumaidy , Alharbi Waleed Snaid , Aldhafeeri Mater Mazi Munahi , Alharbi Yousef Fraih Faisl , Al Ghamdi Fatimah Bakhit , Al Azmi Salmah Mansour , Alfazi Raed Muawwadh Aifan , Al osaimi Ayad theeb mubark , Al Ruwaily Atallah Zewaiben , Mubaraki Abeer Yahya Ahmed
Published: January 2025

Background: Burn injuries affect nearly 500,000 individuals annually, with significant implications for anesthesia management. The unique pathophysiology of burns, including airway management, hemodynamic instability, and altered metabolic responses, poses challenges for anesthesiologists. Inhalation injuries, particularly those affecting the upper airway, and systemic complications, complicate anesthesia care for burn patients. Aim: This review aims to update anesthesiologists and nursing professionals on the critical aspects of anesthetic management in burn patients, emphasizing airway management, fluid resuscitation, ventilation strategies, and addressing inhalation injuries. Methods: The article provides a comprehensive review of the pathophysiological changes that occur in burn patients, with a focus on the distinct phases of burn shock and hypermetabolic response. It discusses the anatomy, physiology, and systemic effects of burn injuries, as well as the anesthetic considerations for managing these complex cases, including airway management, ventilation strategies, and the handling of inhalation injuries. Results: The review identifies key challenges, such as airway obstruction due to supraglottic edema, the need for careful fluid management during the burn shock phase, and the importance of optimizing ventilation strategies to avoid complications like ARDS. The article emphasizes the role of fiberoptic intubation in managing difficult airways and highlights the systemic effects of inhalation injuries, such as hypoxia and acidosis. Conclusion: Effective anesthesia management for burn patients requires a thorough understanding of their unique pathophysiological conditions and careful planning. The use of appropriate anesthetic agents, careful airway management, and vigilant monitoring of systemic effects are essential in ensuring optimal outcomes. Multidisciplinary collaboration between anesthesiologists, nurses, and other healthcare professionals is critical in managing burn patients effectively
Oral and Systemic Health in Older Adults: The Imperative Role of Nurses and Dentists in Integrated Smoking Cessation Programs
Authors: Alsulami Musab Abdullah , Oraybi Ahmed Taher Shui , Alharbi Abeer Ahmad , ALQASIMI SAUD NAHI , Alnakle Roqaih Hussain , SHAREEF OTHMAN MOHAMMED , Al-Otaibi Khaled Saad Misfer , Al-Balawi Nora Mohammed Najih , Habtar Ameera Saeed , Sofyani Heyala Yahya , Alanzi Abdullah Munadi , Alqahtani Mathkar Eid , Alkhatib Amad Jehad , Alharthy Areej Awwad
Published: January 2025

Background: Oral health is a critical component of overall health, particularly in older adults who face increased risks of oral and systemic diseases. Despite the preventability of many oral disorders, significant disparities exist, exacerbated by factors such as age, socioeconomic status, and access to care. Smoking and other lifestyle choices further complicate these health challenges. Methods: This review synthesizes current literature on the integration of oral health into general healthcare systems for elderly populations. A comprehensive analysis of studies from databases such as PubMed and Google Scholar was conducted, focusing on the roles of dental and nursing professionals in smoking cessation programs and their impact on oral and systemic health. Results: Findings indicate that incorporating oral health into general healthcare services significantly improves health outcomes for older adults. Dental practitioners are essential in advocating for smoking cessation, which can mitigate risks of periodontal disease and other systemic conditions. The review highlights various strategies for integration, including multidisciplinary cooperation, patient education, and addressing common risk factors. Conclusion: The integration of oral health into overall healthcare is vital for enhancing the health of older individuals. By addressing shared risk factors and fostering collaboration among healthcare providers, it is possible to reduce the prevalence of oral disorders and improve quality of life. Policymakers and health organizations must prioritize these strategies to ensure effective healthcare delivery for aging populations
Critical Industries in the Time of Asia-Pacific Geopolitics: Lessons for the Philippines
Authors: Baladjay Deryk Matthew , Carlos Jean Clarisse
Published: January 2025

This study examines the interplay between Asia-Pacific geopolitics and the Philippines' critical industries, focusing on telecommunications, energy, mining, and digital infrastructure. Utilizing a Philippine-centric lens, it explores how geopolitical tensions—particularly between the U.S. and China—affect industry-specific vulnerabilities and value chains. Drawing from qualitative data, including key informant interviews across APEC economies, the research highlights the strategic importance of multilateral cooperation, trade diversification, and policy harmonization within APEC. It integrates World-Systems theory to analyze the systemic impacts of geopolitical dynamics and proposes actionable strategies for bolstering industry resilience while aligning with regional and global development goals.
Gender, Microentrepreneurship, Human Flourishing: Exploring the Experiences of Women Sari-sari Store Owners toward Inclusive Growth
Authors: Rueda Diana , Gutierrez Eylla Laire
Published: January 2025

For years, women’s involvement in entrepreneurial activities has been widely advocated as part of economic development agendas. This is evidenced by numerous initiatives, projects, and roadmaps that promote women's integration into economic activities through entrepreneurship. Underpinning these efforts is the assumption that women's active participation in economic activities leads to improved well-being and empowerment. While this is an essential step toward improving women’s conditions, the realities are more complex. Beyond the economic contributions of such entrepreneurial activities, other facets—such as psychological, social, and political dimensions—also need to be considered. This study primarily addresses the question: “How does women’s engagement in micro-enterprising facilitate their own and their communities’ human flourishing and empowerment?” More specifically, it examines the critical role of sari-sari stores in the socio-economic landscape of the Philippines, with a particular focus on their contributions to community development and women's flourishing and empowerment. While sari-sari store owners often face financial constraints, this research highlights a significant relationship between micro-entrepreneurship, human flourishing, and empowerment. Through the analysis of the Flourishing Index, Secured Flourishing Index measures, and the Empowerment Model, the findings reveal that women sari-sari store owners exhibit high levels of well-being, empowerment, optimism, and resilience, despite limited economic prosperity. The study further explores how sari-sari stores serve not only as micro-retail enterprises but also as platforms for fostering individual and social well-being. The owners demonstrate psychological and social empowerment through the ownership of sari-sari stores, while economic and political empowerment is still a work in progress. The results suggest that women, through the ownership of sari-sari stores, achieve individual well-being while also extending that well-being to their communities. Thus, this study offers a nuanced perspective on the significance of sari-sari stores, not just for the economic development of communities but also for the individual and social well-being of their women owners.
Mejora de la eficiencia de los procesos de producción de paneles fotovoltaicos mediante la aplicación de herramientas de mejora continua
Authors: García Juárez José Alberto , Salazar Medina Marcos , Romero Montoya Mauricio , Alcalde Pérez Gabriela , Ortega Petterson Nuria
Published: January 2025

Este artículo aborda la optimización del proceso de producción de paneles fotovoltaicos en una empresa de Rio Blanco, Veracruz, mediante el uso de tiempos estándar, SMED y Kaizen, a través de un estudio de tiempos, donde se identificaron actividades que afectaban el tiempo de ciclo en procedimientos clave como el laminado, la soldadura y el corte de ribbon. La metodología incluyó la estandarización de procesos, la reorganización de actividades internas y externas mediante SMED, y la implementación de mejoras continuas. Como resultado, se logró reducir el tiempo total necesario para cumplir con la producción mensual de 100 paneles de 56.4 días laborales a 25.12 días, acercándose significativamente a los 25 días disponibles. Estas mejoras no solo optimizan el flujo productivo, sino que también establecen una base para futuras iniciativas de mejora continua.
Estrategias de branding de Golden Bean Co. y su conexión emocional en el consumidor ecuatoriano
Authors: Córdova Durán Edmundo Guillermo
Published: January 2025

En el presente artículo se analiza cómo la marca Golden Bean Co. ha logrado establecer vínculos emocionales en el paladar ecuatoriano. A través de las estrategias de gestión de marcas efectivas, la empresa ha cultivado una identidad de marca que resuena con los valores y aspiraciones del cliente. Se examinan las tácticas utilizadas, como el branding, storytelling, la creación de experiencias de marca mediante la conexión emocional, que han generado lealtad y preferencia entre distintos consumidores. El estudio destaca la importancia de la autenticidad y la responsabilidad social en la percepción de la marca. La investigación finaliza que la estrategia del engagement  con el cliente no solo incrementa las ventas, sino que también fortalece la reputación de la marca en un mercado muy competitivo, sugiriendo que las empresas de chocolate de fino aroma deben alinearse en construir relaciones significativas con sus clientes para lograr un crecimiento sostenible a largo plazo.
Role of Vitamin E in Mitigating the Toxic Effects of Tramadol on Thiobarbituric Acid-Reactive Substances in Male Rabbits
Authors: Fayrouz Khaled
Published: January 2025

This study investigates the role of vitamin E in mitigating the oxidative stress induced by tramadol in male rabbits, as measured by thiobarbituric acid-reactive substances (TBARS) levels in blood, brain, and testes tissues. TBARS levels serve as a reliable indicator of lipid peroxidation and oxidative damage. Tramadol administration significantly increased blood TBARS levels from 2.60 ± 0.017 nmol/ml in the control group to 3.128 ± 0.095 nmol/ml (p < 0.05), reflecting heightened oxidative stress. Vitamin E treatment reduced TBARS levels to 1.69 ± 0.043 nmol/ml, demonstrating its potent antioxidant capacity. In the tramadol + vitamin E group, TBARS levels were moderately reduced to 2.75 ± 0.036 nmol/ml, indicating partial mitigation of oxidative stress. Tramadol treatment elevated brain TBARS levels from 43.8 ± 1.01 nmol/gT in the control group to 48.6 ± 2.02 nmol/gT, indicating oxidative damage to brain lipids. Vitamin E alone reduced TBARS to 39.7 ± 0.71 nmol/gT, showing neuroprotective effects. The tramadol + vitamin E group showed intermediate TBARS levels of 44.38 ± 1.42 nmol/gT, reflecting partial oxidative stress alleviation. Tramadol significantly increased TBARS levels in testes tissue from 13.8 ± 0.69 nmol/gT in controls to 24.0 ± 1.17 nmol/gT (p < 0.05), indicating testicular oxidative stress. Vitamin E treatment reduced TBARS to 11.2 ± 0.23 nmol/gT, while the tramadol + vitamin E group exhibited moderate levels of 14.3 ± 1.70 nmol/gT, suggesting protective effects on reproductive tissue. Tramadol induces significant oxidative stress across all studied tissues, as evidenced by elevated TBARS levels. Vitamin E effectively reduces lipid peroxidation and oxidative damage, highlighting its potential as a therapeutic antioxidant. While the combination of tramadol and vitamin E ameliorates oxidative stress, it does not fully restore TBARS levels to normal. These findings underscore the value of vitamin E in managing oxidative stress associated with tramadol use.
PENGARUH CONTENT MARKETING DAN CITRA MEREK TERHADAP KEPUTUSAN PEMBELIAN KONSUMEN PADA BISNIS SKINCARE
Authors: Chicy Widatama Putri  , Nayla Martasya
Published: January 2025

Content marketing and brand image are two important elements in influencing consumer purchasing decisions. Content marketing focuses on providing informative, relevant, and engaging content to build trust, increase brand awareness, create emotional engagement, and provide information that helps consumers make informed decisions. Meanwhile, a strong brand image plays a vital role in building trust, creating loyalty, providing differentiation in the market, and strengthening emotional connections with consumers. The combination of these two strategies allows companies to not only drive purchases but also build long-term relationships with consumers. With proper management, content marketing and brand image can create significant added value for companies in a competitive market.
CONTRIBUIÇÃO DA GINÁSTICA LABORAL APLICADA NA PREVENÇÃO DAS DOENÇAS OCUPACIONAIS: REVISÃO INTEGRATIVA DA LITERATURA
Authors: Mendonça Ana Tércia Lins de , Jesus Josimar Alessandro de , Gasparini Filho Laércio , Lima Kelly Colombo de , Rodrigues Thainara de Souza , Mensch Monika
Published: January 2025

The practice of gymnastics at work enables the care of the body and at the same time offers a little acquisition, preservation and continuity in the improvement of some physical resources, including aerobic resistance, muscle hypertrophy and flexibility, preventing illnesses as an occupational consequence. This research is descriptive and bibliographical in nature, carried out through a review of the literature identifying works published between the periods 2011 to 2021, that is, in the last 10 years. The collection of material for a survey carried out in 2021 between the months of October and November. Within this perspective, this research aims to highlight the contribution of labor gymnastics to the prevention of occupational diseases. Given all the benefits identified in the Brazilian literature on the practice of gymnastics at work, it is concluded from the research carried out that gymnastics at work, as a physical activity and a quality of life that acts in the prevention of occupational diseases, is an investment every time needed to be strengthened and implemented by many business segments in Brazil.
PREVENÇÃO PELO ENSINO: REDUZINDO A ATRAÇÃO DE JOVENS PELAS ORGANIZAÇÕES CRIMINOSAS
Authors: Closs Charleson Marcelo , Forneck Daniela Neis , Pauczinski Delmiro , Pivetta Denise Maria , Perine Ezequiel Fernando Noster , Silva Fabiano Parmeggiani da , Polletti Jorge Luís Rios , Stein Luís Fernando , Rosa Mara Righes da , Trindade Marcelo Azevedo , Fagundes Paraguay Duarte , Puiati Rogério Berlatto , Lindholz Tiago Marcarini
Published: January 2025

A educação tem um papel essencial na prevenção da criminalidade, especialmente quando se trata da atração de jovens para organizações criminosas. O ensino não apenas oferece oportunidades de desenvolvimento pessoal e profissional, mas também atua como um mecanismo de conscientização e formação de valores que impedem a adoção de comportamentos criminosos. A falta de acesso à educação de qualidade, especialmente em áreas de vulnerabilidade social, contribui para o aumento da criminalidade juvenil, já que os jovens, sem alternativas, podem ser seduzidos por promessas de dinheiro fácil e status dentro dessas organizações. Além disso, a escola pode funcionar como um espaço de socialização e construção de vínculos positivos, distanciando os jovens de ambientes de risco. Ao promover a inclusão educacional, com políticas públicas voltadas para a melhoria do ensino e programas que mantenham os jovens engajados, é possível combater o crescimento das facções criminosas. Assim, o fortalecimento do sistema educacional torna-se uma estratégia eficaz para diminuir a adesão de jovens ao crime organizado.
A cozinha afro-brasileira nos cursos de gastronomia do município de Fortaleza (CE): uma breve análise
Authors: Menezes Natália Viviane Santos de , Cunha Junior Henrique
Published: January 2025

Esta pesquisa investigou os currículos dos cursos de Gastronomia ofertados por Instituições de Ensino em Fortaleza/CE para identificar a presença das contribuições africanas e afro-brasileiras no ensino e na formação de egressos. Analisaram-se matrizes curriculares de instituições públicas e privadas, considerando as Diretrizes Curriculares Nacionais para a Educação das Relações Étnico-raciais e para o Ensino de História e Cultura Afro-brasileira e Africana. A pesquisa verificou a oferta de disciplinas sobre cultura, história e culinária africanas e afro-brasileiras. Constatou-se a ausência sintomática desses conteúdos, refletindo uma matriz curricular eurocentrada. A pesquisa evidenciou a necessidade de ampliar o debate pedagógico sobre a diversidade cultural e étnico-racial nos currículos de Gastronomia. O atual cenário educacional fortalezense, no campo da Gastronomia, ainda reflete os efeitos do colonialismo e do racismo estrutural.
Freiras das Bolachas: memória cultural e patrimônio identitário da doçaria conventual portuguesa
Authors: Portocarrero Maria Luísa
Published: January 2025

Este artigo analisou a noção de patrimônio cultural imaterial, no âmbito da convenção da Organização das Nações Unidas para a Educação, Ciência e Cultura (UNESCO) de 2003 para a sua salvaguarda, com foco em comunidades religiosas portuguesas que mantêm práticas gastronômicas tradicionais. O trabalho teve como propósito compreender se a doçaria portuguesa poderia ser considerada um patrimônio cultural imaterial nos termos definidos pela UNESCO. Para tanto, procurou identificar, por meio de entrevistas com freiras de sete conventos em Portugal, traços da transmissão intergeracional, da preservação da memória cultural e da construção de identidade de grupo ao redor de um saber gastronômico tradicional, a confecção de doces.
Alimentação, ritual e reconstrução da Casa Sagrada em Timor-Leste
Authors: Coutinho Luisa
Published: January 2025

Este artigo baseia-se em um trabalho de campo desenvolvido em Timor-Leste, em 2018, e parte da visita a uma aldeia montanhosa para observar e participar nas cerimónias e rituais para a reconstrução de uma Casa Sagrada ou Uma Lulik. Esta comunidade, país e região enquadram-se nas chamadas “sociedade de casas” em que a Casa pode ser entendida como grupo de parentesco, unidade ritual e política que tem na alimentação e nos rituais uma forma de legitimação. Durante as cerimónias, tornou-se evidente a importância dos rituais, dos sacrifícios animais, da divisão da sua carne na renovação dos laços de aliança entre as Casas recetoras de mulheres e Casas dadoras de mulheres, dos espécimes alimentares servidos no banquete e da presença do ambiente natural e da sua transformação à mesa. Este foi um pretexto para a partir da origem, circulação entre territórios, produção e consumo dos alimentos identificados, refletir sobre como os alimentos de origem vegetal e animal são apropriados, percecionados e transformados e, como seres sencientes de acordo com crenças animistas, se tornam alimentos rituais.
Formação no bacharelado em gastronomia: análise por eixos temáticos disciplinares
Authors: Braga Lucas , Amaral Cássia Santos , Sousa Paulo Henrique Machado , Bezerra José Arimatéa Barros , Nunes Fátima Miranda , Lima Francisca Elisângela Teixeira
Published: January 2025

Este estudo teve como objetivo analisar os eixos temáticos disciplinares dos bacharelados em gastronomia das universidades públicas federais brasileiras. O método qualitativo utilizou o método exploratório documental com base nos Projetos Pedagógicos de Cursos (PPCs). O estudo contemplou um total de cinco instituições. Embora não exista uma diretriz curricular nacional específica, os cursos demonstram um alinhamento mínimo na oferta de disciplinas obrigatórias e optativas, conforme os eixos temáticos levantados: i) Comunicação e Idiomas; ii) Gestão, Planejamento e Empreendedorismo; iii) Práticas e Técnicas Gastronômicas; iv) Educação e Humanidades; v) Ciência e Tecnologia dos Alimentos; e vi) Produção Científica em Gastronomia. Os currículos refletem o esforço de cada instituição em construir uma gastronomia plural, adaptada à sua realidade. Contudo, há limitações na distribuição e aprofundamento de cada eixo temático. Este estudo sugere o desenvolvimento de novas pesquisas para análises mais aprofundadas e específicas, visando detalhar as habilidades que o bacharelado em gastronomia se propõe a desenvolver. A relevância dessas pesquisas reside tanto na melhoria contínua dos PPCs dos cursos de gastronomia, quanto na segurança profissional dos egressos em explorar diversos espaços no mercado de trabalho. Destaca-se que uma melhoria nessas distribuições possibilitará ao egresso uma visão mais ampla e segura dos espaços que podem ser ocupados, bem como um olhar para a alimentação como elemento transversal e multidisciplinar.
Impacto dos inibidores de checkpoint imunológico em câncer de pulmão não pequenas células – Revisão Sistemática
Authors: Carvalhaes de Almeida Borges Silva Moara , Alves Fernandes Arthur , De Almeida Gemellaro Moreira Vinicius , Gambi Silva Santos Phillipe , Andrade Mota Maia Camacho Iuryh , Pinheiro Willner Bernardo , Pimentel Fogaça de Souz Carolina , Cordeiro Aragon João Pedro , Davi Alves Pontes Icaro , Lacerda de Oliveira Pessôa Lucas , De Lima Vilas Boas Tullio , Dutra Delage da Silva Heitor
Published: January 2025

Introdução: O câncer de pulmão não pequenas células (CPNPC) é responsável por 85% dos casos de câncer de pulmão, caracterizado por alta mortalidade e resistência aos tratamentos convencionais. Os inibidores de checkpoint imunológico (ICIs) surgiram como alternativa inovadora, melhorando sobrevida global (OS), progressão livre de doença (PFS) e qualidade de vida (QoL). Metodologia: Foi realizada uma revisão sistemática na base PubMed, incluindo estudos publicados entre 2019 e 2024. Foram analisados 15 artigos que abordaram o uso de ICIs em pacientes adultos com CPNPC, avaliando desfechos de OS, PFS e QoL. Resultados: Os ICIs mostraram benefícios significativos em monoterapia e combinações com quimioterapia. O cemiplimabe apresentou PFS de 8,2 meses versus 5,7 meses com quimioterapia. Combinações com agentes como docetaxel e anlotinibe ampliaram a eficácia, especialmente em pacientes com biomarcadores elevados (PD-L1 e bTMB). Melhorias na QoL foram relatadas, mas há lacunas na sua avaliação sistemática. Discussão: Os ICIs demonstraram eficácia no CPNPC, com ganhos importantes em OS, PFS e QoL. Biomarcadores e combinações terapêuticas foram fundamentais para maximizar os resultados. Contudo, desafios relacionados à toxicidade e avaliação abrangente da QoL exigem mais estudos. Conclusão: ICIs revolucionaram o tratamento do CPNPC, superando as abordagens convencionais, especialmente em subgrupos específicos. Estudos futuros são necessários para otimizar estratégias terapêuticas e ampliar os benefícios clínicos.
INVESTIGATION OF THE EFFECT OF REMOTE ISCHEMIC PRECONDITIONING ON THE METABOLOME IN PATIENTS UNDERGOING VASCULAR SURGERY
Authors:   Astrakhan State Medical University of the Ministry of Health of the Russian Federation, Mirzayeva I.I. , Goisoltanova I.Z. ,   Astrakhan State Medical University of the Ministry of Health of the Russian Federation
Published: January 2025

The aim was to investigate the effect of remote ischemic preconditioning (RIPC) on the metabolic profile of patients undergoing elective vascular surgery 24 hours after the intervention. Materials and methods. A randomized, double-blind, placebo-controlled trial was conducted at the Republican Clinical Hospital in Makhachkala from January 1, 2023 to March 1, 2024. We studied patients who had to undergo surgery for an infrarenal abdominal aortic aneurysm, carotid endarterectomy, or revascularization of the lower extremities. Participants received RIPC or placebo, after which 103 metabolites and metabolic ratios were analyzed using the AbsoluteIDQ®p180 kit. Results. The study included 26 patients, 12 of them in the RIPC group and 14 in the control group. In the RIPC group, significant correlations were found between changes in metabolites (for example, the kynurenine/tryptophan ratio) and cardiomarkers (hs-TnT, NT-proBNP), which were absent in the control group. In the control group, blood pressure correlated with creatinine and beta-2-microglobulin levels. Conclusions. RIPC can affect specific metabolic changes after vascular surgery, which is confirmed by correlations with cardiomarkers not found in the control group.
Exploring Accelerated Failure Time Models for Tuberculosis Survival: Loglogistic and Weibull Survival Regression Model
Authors: Usman Abubakar , Doguwa Sani Ibrahim , Sadiq Ibrahim Abubakar , Akor Augustina
Published: January 2025

Tuberculosis (TB) remains a significant global health burden, necessitating robust statistical models to understand survival dynamics and inform interventions. Most survival analyses rely on the Cox Proportional Hazards (Cox PH) model, which may not adequately capture the survival time distribution. This study focuses on data from the National Tuberculosis and Leprosy Center (NTLC), Zaria, Kaduna State, Nigeria, to identify factors influencing TB survival and assess alternative parametric survival models. The study aims to identify factors associated with TB mortality, assess their impact on survival outcomes, and compare the performance of Weibull, and Log-Logistic Accelerated Failure Time (AFT) models to determine the most suitable model for TB survival data from NTLC Zaria. This study compares the performance of two Accelerated Failure Time (AFT) models, the Weibull, and the Log-Logistic in analyzing TB survival data. The analysis evaluates model fit using p-values, log-likelihood, and Akaike Information Criterion (AIC). Results indicate that the Weibull AFT model outperforms the Log-logistic, with the highest log-likelihood (-228.6) and the lowest AIC (485.11), and the Log-Logistic AFT model (AIC: 492.02, log-likelihood: -232.0). The p-values for both models demonstrate statistical significance, highlighting their effectiveness in modelling TB survival data. However, the Weibull model's higher performance suggests it better captures survival time variability in TB patients. These findings emphasize the importance of selecting appropriate survival models for TB data analysis and support the application of the Weibull AFT model for future studies. Further research should explore integrating advanced statistical techniques and machine learning approaches to enhance predictive accuracy and improve TB management strategies. This study contributes to this growing field by applying parametric survival models, to analyse TB survival data from the National Tuberculosis and Leprosy Centre (NTLC) in Zaria, Nigeria.
PAGGALUGAD SA ISINAHOL AT PAGBAWI NG DANGAL: ANG PAGLALAKBAY NG PERSONANG ‘AKO’ NI BAYANI S. ABADILLA SA SIGLIWA KAMAO AYON SA ‘AKO’ NI ALEJANDRO G. ABADILLA
Authors: Umil Roberto Ofanda
Published: January 2025

Kaakibat ng advokasi para sa pagbabago ang henera realismong panlipunan sa disiplina ng malikhaing pagsusulat, litaw ito maging sa Sigliwa Kamao (SK), antolohiya ng panulaan ni Bayani S. Abadilla, may poetikang ‘Wisyo ng masang Pinoy,’ ‘diwang anakpawis o proletaryo.’ Inilalantad ng panulat ni Bayani, nakasanayan tawaging ‘Ka Bay’ ng mga kaibigan, ang batayang suliranin sa kaayusang panlipunang nagsasalaylayan sa malawak na produktibong hanay ng mamamayan: magsasaka, manggagawa; karaniwang profesyonal, negosyante. Tulad ng tradisyong ginagad ng GAT o Galian sa Arte at Tula (post-Rio Alma 1993 mula 1989), GAT (1986 mula 1973),1 mga manunulat sa Wikang Pilipino/Tagalog pagkatapos, habang may Ikalawang Digmaang Pandaigdig, pabalik sa unang hati ng ika-20 dantaon, na inilatag ng Mapaghimagsik (Andres Bonifacio, Emilio Jacinto, et al), at Propagandista (Jose Rizal, Marcelo H. del Pilar, et al). Gamit ang dalumat ng unang panauhan na personang panghalip na ako (umuugat sa Asyanong tradisyon) ni Alejandro G. Abadilla (AGA), bayani ni Zeus Salazar, at pagsusuring diskursong kritikal, ihaharap dito ang poesiya ng SK na naglalahad sa kontextong hinantungan ng malawak na mamamayang tinulaan. Gayon din, ang personang ‘ako,’ at poetika ng autor na gumalugad sa pag-akdang bayan upang suungin ang responsabilidad na mag-ambag sa ikalulubos ng dangal para sa soberanya ng bansa. Hangarin ng pag-aaral na maisalarawan ang mga katangiang taglay, at kinakatawan ng personang ‘ako’ ni Ka Bay bilang isa sa tagapagpadaloy ng naratibo ng pagbabago sa unang dalawang dekada ng ika-21 dantaon. Bagaman hindi pahambing ang pag-aaral na ito, lumilitaw na ang personang ‘ako’ ni Ka Bay ay may ibang pamantayan sa ako ni AGA.
SA DULO NG LUBID: PAGHILA SA ELEPANTE, KASAMA, AT DAGAT
Authors: Buenaflor Arnold Tristan L.
Published: January 2025

Hindi ko na muling maisusulat ang ganitong akda.

Napakaespisipiko ng aking kalagayang mental, espiritwal, at emosyunal nang isulat ang akdang ito. Isang sitwasyon na ayoko nang balikan. Ito ay bunga ng pagsagip sa sarili sa mga panahong matindi ang lahat ng balikong porma ng paghila.

Nakatatakot magsulat tungkol sa pangkalusugang mental. Kahit na, sabihin na nating personal na sanaysay ito at may pribilehiyo ako’ng isulat ang aking nararamdaman, nandiyan din ang aking pag-iingat na ‘wag romantisahin ito sa pamamagitan ng pagtago sa mabulaklak na mga metapora at literary technique. Hindi magkakamali ang mambabasa na ito ay paksa na tumatalakay sa pangkalusugang mental.

Ngunit, ito ay patungkol din sa natagpuang mapagpalayang porma ng paghila. Pag-asa. Sa pagsasanaysay ng pag-asa ko itinuon ang kontra-hila sa akda. Binigyan ko ng pangalan ang mga tao at lugar na sumagip sa akin dahil ito ang mahahalagang paghila na madalas na nakakalimutan. Ito ang mga paghila na may halaga. Paghila pataas. Paghila pasulong.