bluuebunny/crossref_metadata_2025 huggingface dataset:
Effects of Acute Normobaric Hypoxia on Memory Interference
Authors: Loprinzi Paul D. , Matalgah Aala’a , Crawford Lindsay , Yu Jane J. , Kong Zhaowei , Wang Bo , Liu Shijie , Zou Liye
Published: November 2019

Purpose: Previous research has evaluated the effects of acute hypoxia exposure on cognitive function, notably executive function. No studies, to date, have evaluated the effects of acute hypoxia exposure on memory interference, which was the purpose of this experiment. Methods: A within-subjects, counterbalanced experimental design was employed, with condition (hypoxia vs. normoxia) and time (immediate vs. delayed) being the independent variables. Participants (N = 21; Mage = 21.0 years) completed two laboratory visits, involving 30 min of exposure to either hypoxia (FIO2 = 0.12) or normoxia (FIO2 = 0.21). Following this, they completed a memory interference task (AB/AC paradigm), assessing immediate and delayed proactive and retroactive interference. Results: For retroactive interference, we observed a significant main effect for condition, F(1, 20) = 5.48, p = 0.03, ƞ2 = 0.10, condition by time interaction, F(1, 20) = 4.96, p = 0.03, ƞ2 = 0.01, but no main effect for time, F(1, 20) = 1.75, p = 0.20, ƞ2 = 0.004. Conclusion: Our results demonstrate that acute hypoxia exposure was facilitative in reducing memory interference. We discuss these findings in the context of the potential therapeutic effects of acute hypoxia exposure on synaptic plasticity.
Functionalization of Carbon Nanomaterials for Biomedical Applications
Authors: Liu Wei , Speranza Giorgio
Published: November 2019

Over the past decade, carbon nanostructures (CNSs) have been widely used in a variety of biomedical applications. Examples are the use of CNSs for drug and protein delivery or in tools to locally dispense nucleic acids to fight tumor affections. CNSs were successfully utilized in diagnostics and in noninvasive and highly sensitive imaging devices thanks to their optical properties in the near infrared region. However, biomedical applications require a complete biocompatibility to avoid adverse reactions of the immune system and CNSs potentials for biodegradability. Water is one of the main constituents of the living matter. Unfortunately, one of the disadvantages of CNSs is their poor solubility. Surface functionalization of CNSs is commonly utilized as an efficient solution to both tune the surface wettability of CNSs and impart biocompatible properties. Grafting functional groups onto the CNSs surface consists in bonding the desired chemical species on the carbon nanoparticles via wet or dry processes leading to the formation of a stable interaction. This latter may be of different nature as the van Der Waals, the electrostatic or the covalent, the π-π interaction, the hydrogen bond etc. depending on the process and on the functional molecule at play. Grafting is utilized for multiple purposes including bonding mimetic agents such as polyethylene glycol, drug/protein adsorption, attaching nanostructures to increase the CNSs opacity to selected wavelengths or provide magnetic properties. This makes the CNSs a very versatile tool for a broad selection of applications as medicinal biochips, new high-performance platforms for magnetic resonance (MR), photothermal therapy, molecular imaging, tissue engineering, and neuroscience. The scope of this work is to highlight up-to-date using of the functionalized carbon materials such as graphene, carbon fibers, carbon nanotubes, fullerene and nanodiamonds in biomedical applications.
Micrometric Growth Defects of DLC Thin Films
Authors: Maerten Thibault , Jaoul Cédric , Oltra Roland , Duport Patrice , Le Niniven Christophe , Tristant Pascal , Meunier Frédéric , Jarry Olivier
Published: November 2019

Defects in diamond-like carbon coatings deposited on corrosion sensitive 100Cr6 steel have been studied. Diamond-like carbon (DLC) thin films are promising for corrosion protection due to chemical inertness and low electrical conductivity. Nevertheless, the performance of these coating is highly sensitive to the presence of uncoated areas. These defects represent the primary way of substrate degradation in aggressive environments. An in situ optical microscopy coupled to an electrochemical activation was developed to reveal micrometric growth defects and observe that they were at the origin of corrosion. A square wave voltammetry was applied to increase the sensitivity of electrochemical techniques based on the detection of the dissolution of the bare metal surface triggered by the presence of uncoated spots. This method can be utilized to quantify defect density arising from vapor deposition processes.
Cell Surface GRP78 as a Death Receptor and an Anticancer Drug Target
Authors: Ge Ruowen , Kao Chieh
Published: November 2019

Cell surface GRP78 (csGRP78, glucose-regulated protein 78 kDa) is preferentially overexpressed in aggressive, metastatic, and chemo-resistant cancers. GRP78 is best studied as a chaperone protein in the lumen of endoplasmic reticulum (ER), facilitating folding and secretion of the newly synthesized proteins and regulating protein degradation as an ER stress sensor in the unfolded protein pathway. As a cell surface signal receptor, multiple csGRP78 ligands have been discovered to date, and they trigger various downstream cell signaling pathways including pro-proliferative, pro-survival, and pro-apoptotic pathways. In this perspective, we evaluate csGRP78 as a cell surface death receptor and its prospect as an anticancer drug target. The pro-apoptotic ligands of csGRP78 discovered so far include natural proteins, monoclonal antibodies, and synthetic peptides. Even the secreted GRP78 itself was recently found to function as a pro-apoptotic ligand for csGRP78, mediating pancreatic β-cell death. As csGRP78 is found to mainly configur as an external peripheral protein on cancer cell surface, how it can transmit death signals to the cytoplasmic environment remains enigmatic. With the recent encouraging results from the natural csGRP78 targeting pro-apoptotic monoclonal antibody PAT-SM6 in early-stage cancer clinical trials, the potential to develop a novel class of anticancer therapeutics targeting csGRP78 is becoming more compelling.
The Dynamics of Climate Change Adaptation in Sub-Saharan Africa: A Review of Climate-Smart Agriculture among Small-Scale Farmers
Authors: Abegunde Victor O. , Sibanda Melusi , Obi Ajuruchukwu
Published: November 2019

Climate-smart agriculture (CSA) as a credible alternative to tackle food insecurity under the changing climate is gaining wide acceptance. However, many developing countries have realized that concepts that have been recommended as solutions to existing problems are not suitable in their contexts. This paper synthesizes a subset of literature on CSA in the context of small-scale agriculture in sub-Saharan Africa as it relates to the need for CSA, factors influencing CSA adoption, and the challenges involved in understanding and scaling up CSA. Findings from the literature reveal that age, farm size, the nature of farming, and access to extension services influence CSA adoption. Many investments in climate adaptation projects have found little success because of the sole focus on the technology-oriented approach whereby innovations are transferred to farmers whose understanding of the local farming circumstances are limited. Climate-smart agriculture faces the additional challenge of a questionable conceptual understanding among policymakers as well as financing bottlenecks. This paper argues that the prospects of CSA in small-scale agriculture rest on a thorough socio-economic analysis that recognizes the heterogeneity of the small farmer environment and the identification and harnessing of the capacities of farming households for its adoption and implementation.
Tree Cover for the Year 2010 of the Metropolitan Region of São Paulo, Brazil
Authors: Wagner Fabien H. , Hirye Mayumi C.M.
Published: November 2019

Mapping urban trees with images at a very high spatial resolution (≤1 m) is a particularly relevant recent challenge due to the need to assess the ecosystem services they provide. However, due to the effort needed to produce these maps from tree censuses or with remote sensing data, few cities in the world have a complete tree cover map. Here, we present the tree cover data at 1-m spatial resolution of the Metropolitan Region of São Paulo, Brazil, the fourth largest urban agglomeration in the world. This dataset, based on 71 orthorectified RGB aerial photographs taken in 2010 at 1-m spatial resolution, was produced using a deep learning method for image segmentation called U-net. The model was trained with 1286 images of size 64 × 64 pixels at 1-m spatial resolution, containing one or more trees or only background, and their labelled masks. The validation was based on 322 images of the same size not used in the training and their labelled masks. The map produced by the U-net algorithm showed an excellent level of accuracy, with an overall accuracy of 96.4% and an F1-score of 0.941 (precision = 0.945 and recall = 0.937). This dataset is a valuable input for the estimation of urban forest ecosystem services, and more broadly for urban studies or urban ecological modelling of the São Paulo Metropolitan Region.
On Integrating Size and Shape Distributions into a Spatio-Temporal Information Entropy Framework
Authors: Leibovici Didier G. , Claramunt Christophe
Published: November 2019

Understanding the structuration of spatio-temporal information is a common endeavour to many disciplines and application domains, e.g., geography, ecology, urban planning, epidemiology. Revealing the processes involved, in relation to one or more phenomena, is often the first step before elaborating spatial functioning theories and specific planning actions, e.g., epidemiological modelling, urban planning. To do so, the spatio-temporal distributions of meaningful variables from a decision-making viewpoint, can be explored, analysed separately or jointly from an information viewpoint. Using metrics based on the measure of entropy has a long practice in these domains with the aim of quantification of how uniform the distributions are. However, the level of embedding of the spatio-temporal dimension in the metrics used is often minimal. This paper borrows from the landscape ecology concept of patch size distribution and the approach of permutation entropy used in biomedical signal processing to derive a spatio-temporal entropy analysis framework for categorical variables. The framework is based on a spatio-temporal structuration of the information allowing to use a decomposition of the Shannon entropy which can also embrace some existing spatial or temporal entropy indices to reinforce the spatio-temporal structuration. Multiway correspondence analysis is coupled to the decomposition entropy to propose further decomposition and entropy quantification of the spatio-temporal structuring information. The flexibility from these different choices, including geographic scales, allows for a range of domains to take into account domain specifics of the data; some of which are explored on a dataset linked to climate change and evolution of land cover types in Nordic areas.
Recognition of a Single Dynamic Gesture with the Segmentation Technique HS-ab and Principle Components Analysis (PCA)
Authors: Contreras Alejo Diana Alejandra , Gallegos Funes Francisco Javier
Published: November 2019

A continuous path performed by the hand in a period of time is considered for the purpose of gesture recognition. Dynamic gestures recognition is a complex topic since it spans from the conventional method of separating the hand from surrounding environment to searching for the fingers and palm. This paper proposes a strategy of hand recognition using a PC webcam, a segmentation technique (HS-ab which means HSV and CIELab color space), pre-processing of images to reduce noise and a classifier such as Principle Components Analysis (PCA) for the detection and tracking of the hand of the user. The results show that the segmentation technique HS-ab and the method PCA are robust in the execution of the system, although there are various conditions such as illumination, speed and precision of the movements. It is for this reason that a suitable extraction and classification of features allows the location of the gesture. The system was tested with the database of the training images and has a 94.74% accuracy.
Complex Chaotic Attractor via Fractal Transformation
Authors: Dai Shengqiu , Sun Kehui , He Shaobo , Ai Wei
Published: November 2019

Based on simplified Lorenz multiwing and Chua multiscroll chaotic systems, a rotation compound chaotic system is presented via transformation. Based on a binary fractal algorithm, a new ternary fractal algorithm is proposed. In the ternary fractal algorithm, the number of input sequences is extended from 2 to 3, which means the chaotic attractor with fractal transformation can be presented in the three-dimensional space. Taking Lorenz system, rotation Lorenz system and compound chaotic system as the seed chaotic systems, the dynamics of the complex chaotic attractors with fractal transformation are analyzed by means of bifurcation diagram, complexity and power spectrum, and the results show that the chaotic sequences with fractal transformation have higher complexity. As the experimental verification, one kind of complex chaotic attractors is implemented by DSP, and the result is consistent with that of the simulation, which verifies the feasibility of digital circuit implement.
Information Flow between Bitcoin and Other Investment Assets
Authors: Jang Sung Min , Yi Eojin , Kim Woo Chang , Ahn Kwangwon
Published: November 2019

This paper studies the causal relationship between Bitcoin and other investment assets. We first test Granger causality and then calculate transfer entropy as an information-theoretic approach. Unlike the Granger causality test, we discover that transfer entropy clearly identifies causal interdependency between Bitcoin and other assets, including gold, stocks, and the U.S. dollar. However, for symbolic transfer entropy, the dynamic rise–fall pattern in return series shows an asymmetric information flow from other assets to Bitcoin. Our results imply that the Bitcoin market actively interacts with major asset markets, and its long-term equilibrium, as a nascent market, gradually synchronizes with that of other investment assets.
Review on Power Performance and Efficiency of Wave Energy Converters
Authors: Aderinto Tunde , Li Hua
Published: November 2019

The level of awareness about ocean wave energy as a viable source of useful energy has been increasing recently. Different concepts and methods have been suggested by many researchers to harvest ocean wave energy. This paper reviews and compares the efficiencies and power performance of different wave energy converters. The types of analyses used in deriving the reported efficiencies are identified, and the stage of the power conversion processes at which the efficiencies were determined is also identified. In order to find a common way to compare the efficiencies of different technologies, the hydrodynamic efficiency in relation to the characteristic width of the wave energy converters and the wave resource potential are chosen in this paper. The results show that the oscillating body systems have the highest ratio in terms of the efficiency per characteristic width, and overtopping devices have the lowest. In addition, with better understanding of the devices’ dynamics, the efficiencies of the newer oscillating water column and body systems would increase as the potential wave energy level increases, which shows that those newer designs could be suitable for more potential locations with large variations in wave energy potentials. At last, discussion about the cost of ocean wave energy is presented as well.
Fault Current Tracing and Identification via Machine Learning Considering Distributed Energy Resources in Distribution Networks
Authors: Fei Wanghao , Moses Paul
Published: November 2019

The growth of intermittent distributed energy sources (DERs) in distribution grids is raising many new operational challenges for utilities. One major problem is the back feed power flows from DERs that complicate state estimation for practical problems, such as detection of lower level fault currents, that cause the poor accuracy of fault current identification for power system protection. Existing artificial intelligence (AI)-based methods, such as support vector machine (SVM), are unable to detect lower level faults especially from inverter-based DERs that offer limited fault currents. To solve this problem, a current tracing method (CTM) has been proposed to model the single distribution feeder as several independent parallel connected virtual lines that traces the detailed contribution of different current sources to the power line current. Moreover, for the first time, the enhanced current information is used as the expanded feature space of SVM to significantly improve fault current detection on the power line. The proposed method is shown to be sensitive to very low level fault currents which is validated through simulations.
Modeling Intraday Markets under the New Advances of the Cross-Border Intraday Project (XBID): Evidence from the German Intraday Market
Authors: Kath Christopher
Published: November 2019

The intraday cross-border project (XBID) allows intraday market participants to trade based on a shared order book independent of countries or local energy exchanges. This theoretically leads to an efficient allocation of cross-border capacities and ensures maximum market liquidity across European intraday markets. If this postulation holds, the technical implementation of XBID might mark a regime switch in any intraday price series. We present a regression-based model for intraday markets with a particular focus on the German European Power Exchange (EPEX) intraday market and evaluate if the introduction of XBID influence prices, volume or volatility. We analyze partial volume-weighted average prices and standard deviations as well as cross-border volumes at different trading times. We are able to falsify our initial hypothesis assuming a measurable influence of changes caused by XBID. Thus, this paper contributes to the ongoing discussion on appropriate modeling of intraday markets and demonstrates that XBID does not necessarily need to be included in any model.
Computationally Efficient Method of Co-Energy Calculation for Transverse Flux Machine Based on Poisson Equation in 2D
Authors: Smoleń Andrzej , Gołębiowski Lesław , Gołębiowski Marek , Mazur Damian
Published: November 2019

The article presents an original method for numerical determination of the value of magnetic co-energy of a transverse construction motor. The aim of the developed method is initial determination of the co-energy value for the analyzed structure in the function of rotor rotation angle. The main requirement set to the presented method was the lowest possible complexity of the process computation, lack of the necessity to apply costly dedicated software, as well as creating construction 3D models. These requirements were met by applying specific cross-section/development of the analyzed machine geometry, as well as application of specific boundary conditions, which enabled reduction of the analyzed problem to solving a Poisson equation in 2D. The calculations were done with the Finite Element Method.
Low Temperature deNOx Catalytic Activity with C2H4 as a Reductant Using Mixed Metal Fe-Mn Oxides Supported on Activated Carbon
Authors: Liu Fang , Yang Li , Cheng Jie , Wu Xin , Quan Wenbin , Saito Kozo
Published: November 2019

The selective catalytic reduction of NOx (deNOx) at temperatures less than or at 200 °C was investigated while using C2H4 as the reductant and mixed oxides of Fe and Mn supported on activated carbon; their activity was compared to that of MnOx and FeOx separately supported on activated carbon. The bimetallic oxide compositions maintained high NO conversion of greater than 80–98% for periods that were three times greater than those of the supported monometallic oxides. To examine potential reasons for the significant increases in activity maintenance, and subsequent deactivation, the catalysts were examined by using bulk and surface sensitive analytical techniques before and after catalyst testing. No significant changes in Brunauer-Emmett-Teller (BET) surface areas or porosities were observed between freshly-prepared and tested catalysts whereas segregation of FeOx and MnOx species was readily observed in the mono-oxide catalysts after reaction testing that was not detected in the mixed oxide catalysts. Furthermore, x-ray diffraction and Raman spectroscopy data detected cubic Fe3Mn3O8 in both the freshly-prepared and reaction-tested mixed oxide catalysts that were more crystalline after testing. The presence of this compound, which is known to stabilize multivalent Fe species and to enhance oxygen transfer reactions, may be the reason for the high and relatively stable NO conversion activity, and its increased crystallinity during longer-term testing may also decrease surface availability of the active sites responsible for NO conversion. These results point to a potential of further enhancing catalyst stability and activity for low temperature deNOx that is applicable to advanced SCR processing with lower costs and less deleterious side effects to processing equipment.
Identification and Quantification of Uncertainty Components in Gaseous and Particle Emission Measurements of a Moped
Authors: Giechaskiel Barouch , Zardini Alessandro A. , Lähde Tero , Clairotte Michael , Forloni Fabrizio , Drossinos Yannis
Published: November 2019

The recent Euro 4 and 5 environmental steps for L-category vehicles (e.g., mopeds, motorcycles) were mainly designed to reduce the emissions of particulate matter and ozone precursors, such as nitrogen oxides and hydrocarbons. However, the corresponding engine, combustion, and aftertreatment improvements will not necessarily reduce the solid particle number (SPN) emissions, suggesting that a SPN regulation may be necessary in the future. At the same time, there are concerns whether the current SPN regulations of passenger cars can be transferred to L-category vehicles. In this study we quantified the errors and uncertainties in emission measurements, focusing on SPN. We summarized the sources of uncertainty related to emission measurements and experimentally quantified the contribution of each uncertainty component to the final results. For this reason, gas analyzers and SPN instruments with lower cut-off sizes of 4 nm, 10 nm, and 23 nm were sampling both from the tailpipe, and from the dilution tunnel having the transfer tube in closed or open configuration (i.e., open at the tailpipe side). The results showed that extracting from the tailpipe 23–28% of the mean total exhaust flow (bleed off) resulted in a 24–31% (for CO2) and 19–73% (for SPN) underestimation of the emissions measured at the dilution tunnel. Erroneous determination of the exhaust flow rate, especially at cold start, resulted in 2% (for CO2) and 69–149% (for SPN) underestimation of the tailpipe emissions. Additionally, for SPN, particle losses in the transfer tube with the closed configuration decreased the SPN concentrations around 30%, mainly due to agglomeration at cold start. The main conclusion of this study is that the open configuration (or mixing tee) without any instruments measuring from the tailpipe is associated with better accuracy for mopeds, especially related to SPN measurements. In addition, we demonstrated that for this moped the particle emissions below 23 nm, the lower size currently prescribed in the passenger cars regulation, were as high as those above 23 nm; thus, a lower cut-off size is more appropriate.
Waste to Carbon: Biocoal from Elephant Dung as New Cooking Fuel
Authors: Stępień Paweł , Świechowski Kacper , Hnat Martyna , Kugler Szymon , Stegenta-Dąbrowska Sylwia , Koziel Jacek A. , Manczarski Piotr , Białowiec Andrzej
Published: November 2019

The paper presents, for the first time, the results of fuel characteristics of biochars from torrefaction (a.k.a., roasting or low-temperature pyrolysis) of elephant dung (manure). Elephant dung could be processed and valorized by torrefaction to produce fuel with improved qualities for cooking. The work aimed to examine the possibility of using torrefaction to (1) valorize elephant waste and to (2) determine the impact of technological parameters (temperature and duration of the torrefaction process) on the waste conversion rate and fuel properties of resulting biochar (biocoal). In addition, the influence of temperature on the kinetics of the torrefaction and its energy consumption was examined. The lab-scale experiment was based on the production of biocoals at six temperatures (200–300 °C; 20 °C interval) and three process durations of the torrefaction (20, 40, 60 min). The generated biocoals were characterized in terms of moisture content, organic matter, ash, and higher heating values. In addition, thermogravimetric and differential scanning calorimetry analyses were also used for process kinetics assessment. The results show that torrefaction is a feasible method for elephant dung valorization and it could be used as fuel. The process temperature ranging from 200 to 260 °C did not affect the key fuel properties (high heating value, HHV, HHVdaf, regardless of the process duration), i.e., important practical information for proposed low-tech applications. However, the higher heating values of the biocoal decreased above 260 °C. Further research is needed regarding the torrefaction of elephant dung focused on scaling up, techno-economic analyses, and the possibility of improving access to reliable energy sources in rural areas.
Strong Disturbance Impact of Tropical Cyclone Lionrock (2016) on Korean Pine-Broadleaved Forest in the Middle Sikhote-Alin Mountain Range, Russian Far East
Authors: Vozmishcheva Anna S. , Bondarchuk Svetlana N. , Gromyko Mikhail N. , Kislov Dmitriy E. , Pimenova Elena A. , Salo Michail A. , Korznikov Kirill A.
Published: November 2019

Tropical cyclones (hurricanes and typhoons) cause large-scale disturbances in forest ecosystems all over the world. In the summer of 2016, a strong tropical cyclone named Lionrock created windthrow patches in the area of more than 400 km2 on the forested eastern slopes of the Sikhote-Alin Range, in the Russian Far East. Such large-scale forest destruction by wind had never been recorded in the area prior to this event. We examined the tropical cyclone impact upon the forest composition, structure and tree mortality rates on two study sites (1 ha and 0.5 ha in size)—a contiguous windthrow patch site, and a site with partial canopy damage. Korean pine (Pinus koraiensis Siebold and Zucc.), Manchurian fir (Abies nephrolepis Trautv.) and Dahurian larch (Larix cajanderi Mayr.) were the primary tree species represented in the affected forest communities. Combined with the partial canopy damage, 7.7% of trees were blown down by the disturbance event. We determined that this one event mortality rate nearly equaled the average mortality rate for a ten year period for these forests (8.5 ± 4.0%) under normal conditions (no large-scale disturbances). Within a contiguous windthrow patch, tree mortality was determined to be 52.6%, which is significantly higher than the cumulative tree loss for the previous 50 years (42.4%). A substantial portion of thinner-stemmed trees (DBH (diameter measured at breast height) < 30 cm) were wind snapped, and those with larger diameters (DBH > 60 cm) were uprooted. Our results indicate that the probability of tree loss due to catastrophic wind loads increases as a result of the decrease in local density. We believe that tree loss estimates should include the impacts within contiguous patches of windthrows, as well as the patches with only partial tree canopy damage. Strong wind impact forecasting is possible with accounting for species composition within the stand sites and their spatial structure.
Influence of Stem Taper on the Yield of Black Spruce Stands and Trees Following Commercial Thinning
Authors: Vincent Manon , Krause Cornelia , Koubaa Ahmed
Published: November 2019

In this work, we examine the effects of commercial thinning on stand volume and individual stem form in nine naturally regenerated black spruce (Picea mariana (Mill.) B.S.P.) stands. We compared these study sites with controls in the commercial boreal forest of northern Quebec, Canada. At stand level, dendrochronological data provided insight into changes in stand volume ten years after thinning. Analysis of a subsample of six individual trees from each commercially thinned stand and three individual trees from the controls illustrated the role of thinning on stem shape development. Although average volume increased for residual stems in thinned stands slightly more than in the controls (110% versus 106%), the treatment effect stand-level volume increment or stand-level total volume harvested (ten years after treatment) was not statistically significant. Moreover, at tree level, thinning did not significantly affect stem volume increment. However, radial growth increment significantly increased after treatment. Trees from commercially thinned stands showed a significantly higher growth increment along the lower first two-thirds of the stem. Response to thinning at tree level correlated strongly with the size and number of harvested competitors around a residual stem. We conclude that commercial thinning modified wood allocation rather than wood volume and did not affect taper and stem shape. These patterns of post-cutting growth are explained by wood allocation following thinning. After commercial thinning, growth increment is favored at the expense of height growth. As the treatment effect was found at the stem scale rather than at the stand scale, further research is needed in regard to commercial thinning treatments to investigate how to increase productivity at the stand scale.
Propagation of Juniper Species by Plant Tissue Culture: A Mini-Review
Authors: Hazubska-Przybył Teresa
Published: November 2019

The genus Juniperus (of the Cupressaceae family) is the second most prevalent group of conifers on Earth. Juniper species are widely dispersed in the Northern Hemisphere, in Europe and Asia, and in Africa and Central America. Juniper species are resistant to dry climates and can adapt to difficult environmental conditions. Most juniper species are important in both ecological and economic terms. However, today, many forests in which junipers occur are being reduced in size due to both natural causes (fires, for example) and human activity (uncontrolled exploitation of forests, etc.). Also, climate changes may have adversely affected the range of populations of different juniper species. For this reason, some juniper species are now categorized as rare or endangered, and require immediate protective action. Therefore, there is an urgent need to develop effective strategies for ex situ conservation, including reliable procedures for Juniperus sp. reproduction for future reintroduction and restoration programs. The conservation strategies used until now with traditional forestry techniques (seed propagation, rooted cuttings, grafting) have not been satisfactory in many cases. Thus, increasing attention is being paid to the possibilities offered by in vitro culture technology, which enables the conservation and mass clonal propagation of different coniferous tree species. In this mini-review, we summarize the current state of knowledge regarding the use of various methods of the propagation of selected Juniperus species, with a particular emphasis on in vitro culture techniques.
Aztec Metaphysics—Two Interpretations of an Evanescent World
Authors: Montiel Jorge
Published: November 2019

This paper contrasts two contemporary approaches to Nahua metaphysics by focusing on the stance of the Nahua tlamatinime (philosophers) regarding the nature of reality. Miguel León-Portilla and James Maffie offer the two most comprehensive interpretations of Nahua philosophy. Although León-Portilla and Maffie agree on their interpretation of teotl as the evanescent principle of Nahua metaphysics, their interpretations regarding the tlamatinime metaphysical stances diverge. Maffie argues that León-Portilla attributes to the tlamatinime a metaphysics of being according to which being means permanence and stability and thus, since earthly things are continuously changing, being cannot be predicated of them, hence earthly things are not real. I present textual support to show that León-Portilla does not read Nahua metaphysics through the lens of a metaphysics of being and thus that León-Portilla does not interpret the tlamatinime as denying the reality of earthly things. I then provide an exegetical analysis of León-Portilla’s texts to show that, in his interpretation, metaphysical concerns are intimately linked to existential questions regarding the meaning of human life. Ultimately, I argue that, in León-Portilla’s interpretation, the tlamatinime conception of art functions as poiesis, that is, as the process of aesthetic creation that gives meaning to human life.
Fictional Crimes/Historical Crimes: Genre and Character in Philip Kerr’s Berlin Noir Trilogy
Authors: Major Laura
Published: November 2019

This paper will explore Philip Kerr’s Berlin Noir trilogy, composed of March Violets (1989), The Pale Criminal (1990), and A German Requiem (1991), discussing the overlap and blurring of generic boundaries in these novels and the ability of this form to reckon with the Holocaust. These detective stories are not directly about the Holocaust, and although the crimes investigated by the mordant Bernie Gunther are fictional, they are interweaved with the greater crimes committed daily by the Nazi Party. The novels are brutally realistic, violent, bleak, and harsh, in a narrative style highly appropriate for crime novels set in Nazi Germany. Indeed, with our knowledge of the enormity of the Nazi crimes, the violence in the novels seems not gratuitous but reflective of the era. Bernie Gunther himself, who is both hard-boiled protagonist and narrator, is a deeply flawed human, even an anti-hero, but in Berlin, which is “alive” as a character in these novels, his insights, cloaked in irony and sarcasm, highlight the struggle to resist, even passively, even just inside one’s own mind, the current of Nazism. Although many representations of the Holocaust in popular fiction strive towards the “feel good” story within the story, Kerr’s morally and generically ambiguous novels never give in to this urge, and the solution of the crime is never redemptive. The darkness of these novels, paired with the popularity of crime fiction, make for a significant vehicle for representing the milieu in which the Holocaust was able to occur.
The Critical Role of Hypoxic Microenvironment and Epigenetic Deregulation in Esophageal Cancer Radioresistance
Authors: Macedo-Silva Catarina , Miranda-Gonçalves Vera , Henrique Rui , Jerónimo Carmen , Bravo Isabel
Published: November 2019

Esophageal cancer (EC) is the seventh most common cancer worldwide and the sixth leading cause of death, according to Globocan 2018. Despite efforts made for therapeutic advances, EC remains highly lethal, portending a five-year overall survival of just 15–20%. Hence, the discovery of new molecular targets that might improve therapeutic efficacy is urgently needed. Due to high proliferative rates and also the limited oxygen and nutrient diffusion in tumors, the development of hypoxic regions and consequent activation of hypoxia-inducible factors (HIFs) are a common characteristic of solid tumors, including EC. Accordingly, HIF-1α, involved in cell cycle deregulation, apoptosis, angiogenesis induction and proliferation in cancer, constitutes a predictive marker of resistance to radiotherapy (RT). Deregulation of epigenetic mechanisms, including aberrant DNA methylation and histone modifications, have emerged as critical factors in cancer development and progression. Recently, interactions between epigenetic enzymes and HIF-1α transcription factors have been reported. Thus, further insight into hypoxia-induced epigenetic alterations in EC may allow the identification of novel therapeutic targets and predictive biomarkers, impacting on patient survival and quality of life.
Cdx2 Animal Models Reveal Developmental Origins of Cancers
Authors: Chawengsaksophak Kallayanee
Published: November 2019

The Cdx2 homeobox gene is important in assigning positional identity during the finely orchestrated process of embryogenesis. In adults, regenerative responses to tissues damage can require a replay of these same developmental pathways. Errors in reassigning positional identity during regeneration can cause metaplasias—normal tissue arising in an abnormal location—and this in turn, is a well-recognized cancer risk factor. In animal models, a gain of Cdx2 function can elicit a posterior shift in tissue identity, modeling intestinal-type metaplasias of the esophagus (Barrett’s esophagus) and stomach. Conversely, loss of Cdx2 function can elicit an anterior shift in tissue identity, inducing serrated-type lesions expressing gastric markers in the colon. These metaplasias are major risk factors for the later development of esophageal, stomach and colon cancer. Leukemia, another cancer in which Cdx2 is ectopically expressed, may have mechanistic parallels with epithelial cancers in terms of stress-induced reprogramming. This review will address how animal models have refined our understanding of the role of Cdx2 in these common human cancers.
Microbiological Safety of Street-Vended Beverages in Chow Kit, Kuala Lumpur
Authors: Mohd Nawawee Nur Syakirah , Abu Bakar Nur Faizah , Zulfakar Siti Shahara
Published: November 2019

Improper handling, poor hygienic practices, and lack of environmental control affect the safety of street-vended beverages. The objective of this study is to determine the bacterial contamination level of three types of beverages (cordial-based drinks, milk-based drinks, fruit juices) sold by street vendors at Chow Kit, Kuala Lumpur. A total of 31 samples of beverages were analyzed to determine total viable count (TVC), total coliform, Escherichia coli, and Staphylococcus aureus counts via the standard plate count method. The results showed that only 9.7% of the total samples were not contaminated with the tested microorganisms. All milk-based drink samples were positive for TVC and also had the highest average bacterial counts at 5.30 ± 1.11 log Colony Forming Unit/mL (CFU/mL). About 71% of the samples were contaminated with total coliform with the average readings ranging between 4.30 and 4.75 log CFU/mL, whereas 58.1% of the samples were positive with S. aureus, with fruit juices having the highest average reading (3.42 ± 1.15 log CFU/mL). Only one sample (milk-based drink) was E. coli positive. This study showed that the microbiological safety level of street-vended beverages in Chow Kit, Kuala Lumpur was average and needs to be improved. Provision of food safety education and adequate sanitary facilities at vending sites are suggested to increase the safety of food products.
Redirecting Research on Fe0 for Environmental Remediation: The Search for Synergy
Authors: Hu Rui , Noubactep Chicgoua
Published: November 2019

A survey of the literature on using metallic iron (Fe0) for environmental remediation suggests that the time is ripe to center research on the basic relationship between iron corrosion and contaminant removal. This communication identifies the main problem, which is based on the consideration that contaminant reductive transformation is the cathodic reaction of iron oxidative dissolution. Properly considering the inherent complexities of the Fe0/H2O system will favor an appropriate research design that will enable more efficient and sustainable remediation systems. Successful applications of Fe0/H2O systems require the collective consideration of progress achieved in understanding these systems. More efforts should be made to decipher the long-term kinetics of iron corrosion, so as to provide better approaches to accurately predict the performance of the next generation Fe0-based water treatment systems.
Policies to Create Healthier Food Environments in Canada: Experts’ Evaluation and Prioritized Actions Using the Healthy Food Environment Policy Index (Food-EPI)
Authors: Vanderlee Lana , Goorang Sahar , Karbasy Kimiya , Vandevijvere Stefanie , L’Abbé Mary R
Published: November 2019

Food environment policies play a critical role in shaping food choices, diets, and health outcomes. This study endeavored to characterize and evaluate the current food environment policies in Canada using the Healthy Food Environment Policy Index (Food-EPI) to compare policies in place or under development in Canada as of 1 January 2017 to the most promising practices internationally. Evidence of policy implementation from the federal, provincial, and territorial governments was collated and verified by government stakeholders for 47 good practice indicators across 13 policy and infrastructure support domains. Canadian policies were rated by 71 experts from across Canada, and an aggregate score of national and subnational policies was created. Potential policy actions were identified and prioritized. Canadian governments scored ‘high’ compared to best practices for 3 indicators, ‘moderate’ for 14 indicators, ‘low’ for 25 indicators, and ‘very little or none’ for 4 indicators. Six policy and eight infrastructure support actions were prioritized as the most important and achievable. The Food-EPI identified some progress and considerable gaps in policy implementation in Canada, and highlights a particular need for greater attention to prioritized policies that can help to shift to a health-promoting food environment.
Risk of Cancer for Workers Exposed to Antimony Compounds: A Systematic Review
Authors: Saerens Anton , Ghosh Manosij , Verdonck Jelle , Godderis Lode
Published: November 2019

Background: Antimony (Sb) trioxide and antimony trisulfide are “2B: Possibly carcinogenic to humans” and “3: Unclassifiable” according to the International Agency for Research on Cancer (IARC). The U.S. National Toxicology Program (NTP) concluded that antimony trioxide “is reasonably anticipated to be a human carcinogen based on studies in rats and mice”. We investigated the cancer hazard of antimony compounds for workers, a population with high exposure to antimony substances. Methods: Using the “Guidelines for performing systematic reviews in the development of toxicity factors” (Texas Commission on Environmental Quality (TCEQ) 2017) as a guidance, we established a human and an animal toxicology data stream in Medline and ToxLine. Data from this review were applied in a human health risk assessment. Results: A final pool of 10 occupational and 13 animal toxicology articles resulted after application of TCEQ guidelines. Conclusions: Antimony carcinogenicity evidence involving workers is inadequate, based on confounding, small sample sizes, incomparability across studies, and inadequate reference populations. An increased lung cancer risk cannot be excluded. Evidence for lung neoplasms caused by antimony trioxide inhalation in experimental animals is sufficient. Overall, carcinogenicity in workers is probable (International Agency for Research on Cancer (IARC) 2A). It remains unclear from what occupational exposure duration and dose this effect arises and whether exposure threshold values should be reconsidered.
The Potential Impact of the New York State Smokers’ Quitline on Population-Level Smoking Rates in New York
Authors: Mann Nathan , Nonnemaker James , Davis Kevin , Chapman LeTonya , Thompson Jesse , Juster Harlan R.
Published: November 2019

Receiving smoking cessation services from telephone quitlines significantly increases quit success compared with no intervention or other quitting methods. To affect population-level smoking, quitlines must provide a sufficient proportion of smokers with effective interventions. Nationally, quitlines reach around 1% of adult smokers annually. From 2011 through 2016, the average annual reach of the New York State Smokers’ Quitline (NYSSQL) was 2.9%. We used data on the reach and cessation outcomes of NYSSQL to estimate its current impact on population-level smoking prevalence and to estimate how much reach would have to increase to achieve population-level smoking prevalence reductions. We estimate NYSSQL is associated with a 0.02 to 0.04 percentage point reduction in smoking prevalence in New York annually. If NYSSQL achieved the recommended annual reach of 8% (CDC Best Practices) and 16% (NAQC), state-level prevalence would decrease by an estimated 0.07–0.12 and 0.13–0.24 percentage points per year, respectively. To achieve those recommended levels of reach, NYSSQL would need to provide services to approximately 3.5 to 6.9 times more smokers annually. Given their reach, quitlines are limited in their ability to affect population-level smoking. Increasing quitline reach may not be feasible and would likely be cost-prohibitive. It may be necessary to re-think the role of quitlines in tobacco control efforts. In New York, the quitline is being integrated into larger efforts to promote cessation through health systems change.
Mapping the Status of Healthcare Improvement Science through a Narrative Review in Six European Countries
Authors: Lillo-Crespo Manuel , Sierras-Davó Maria Cristina , Taylor Alan , Ritters Katrina , Karapostoli Aimilia
Published: November 2019

With the aim to explore how improvement science is understood, taught, practiced, and its impact on quality healthcare across Europe, the Improvement Science Training for European Healthcare Workers (ISTEW) project “Improvement Science Training for European Healthcare Workers” was funded by the European Commission and integrated by 7 teams from different European countries. As part of the project, a narrative literature review was conducted between 2008 and 2019, including documents in all partners’ languages from 26 databases. Data collection and analysis involved a common database. Validation took place through partners’ discussions. Referring to healthcare improvement science (HIS), a variety of terms, tools, and techniques were reported with no baseline definition or specific framework. All partner teams were informed about the non-existence of a specific term equivalent to HIS in their mother languages, except for the English-speaking countries. A lack of consensus, regarding the understanding and implementation of HIS into the healthcare and educational contexts was found. Our findings have brought to light the gap existing in HIS within Europe, far from other nations, such as the US, where there is a clearer HIS picture. As a consequence, the authors suggest further developing the standardization of HIS understanding and education in Europe.