bluuebunny/crossref_metadata_2025 huggingface dataset:
PRODUCTION OF CHIMERIC AFRICAN SWINE FEVER VIRUSES EXPRESSING P54 AND P30 HETEROLOGUE PROTEINS
Authors: Кольцова Г.С. , Сухер М.М. , Рудакова С. , Крутько С.А. , Белов С.В. , Холод Н.С. , Кольцов А.Ю.
Published: September 2024

Африканская чума свиней (АЧС) – вирусная геморрагическая лихорадка диких и домашних свиней с летальностью до 100%, которая, возможно, является наиболее серьезной угрозой свиноводства во всем мире. Распространение болезни за пределы Африки на территорию России (с 2007 г.), европейских стран (с 2014 г.) и стран Азии (с 2018 г.) привело к огромным экономическими потерям и серьезным экологическим последствиям. Стоит отметить, что до сих пор не зарегистрированы вакцины для профилактики АЧС. Тем не менее, продемонстрировано, что иммунизация рекомбинантными и живыми ослабленными вирусами может обеспечивать защиту от заражения гомологичными штаммами вируса. К сожалению, молекулярные и иммунологические механизмы развития иммунитета при АЧС плохо изучены. Доступные данные экспериментов по вакцинации/заражению свиней указывают на то, что защитный иммунитет против АЧС является серотипоспецифичным.

African swine fever (ASF) is a viral hemorrhagic fever of wild and domestic pigs with a mortality rate of up to 100%, which is perhaps the most serious threat to pig production worldwide. The spread of the disease beyond Africa to Russia (since 2007), European countries (since 2014) and Asian countries (since 2018) has led to huge economic losses and serious environmental consequences. It should be noted that no vaccines for the prevention of ASF have been registered so far. However, it has been demonstrated that immunization with recombinant and live attenuated viruses can provide protection against challenge with homologous strains of the virus. Unfortunately, the molecular and immunological mechanisms for the development of immunity in ASF are poorly understood. Available data from pig vaccination/challenge experiments indicate that protective immunity against ASF is serotype-specific.
INFLUENCE OF THE NUTRIENT MEDIUM ON EMBRYOGENESIS IN THE CULTURE OF ISOLATED MICROSporeS OF CABBAGE CULTURES
Authors: Вишнякова А.В. , Синицина А.А. , Монахос С.Г.
Published: September 2024

Возможность быстро создать полностью гомозиготное растение привлекает исследователей различных направлений – селекционеров, генетиков и биотехнологов. Гомозиготные растения, так называемые удвоенные гаплоиды, получают путем отдаленной гибридизации, с последующей элиминацией хромосом, партеногенезом, а также биотехнологическими методами: в культуре изолированных микроспор, в культуре пыльников и культуре изолированных семязачатков.

The ability to quickly create a completely homozygous plant attracts researchers from various fields - breeders, geneticists and biotechnologists. Homozygous plants, the so-called doubled haploids, are obtained by distant hybridization, followed by elimination of chromosomes, parthenogenesis, as well as by biotechnological methods: in the culture of isolated microspores, in the culture of anthers and in the culture of isolated ovules.
USING THE METHOD OF EMBRYOCULTURE TO OBTAIN INTERSPECIFIC HYBRIDS BRASSICA × RAPHANUS
Authors: Спивак В.В.
Published: September 2024

Отдаленная гибридизация – один из методов селекции для решения ключевых проблем современного растениеводства, позволяющий создать генотипы с уникальным набором хозяйственно-ценных признаков. Его использование сопряжено с трудностями по сохранению полученных объектов в результате их гибели на ранних этапах развития. Применение культуры изолированных зародышей для преодоления проблемы гибели зародыша при межвидовой гибридизации широко применяется в селекции различных культур.

Remote hybridization is one of the breeding methods for solving the key problems of modern crop production, which makes it possible to create genotypes with a unique set of economically valuable traits. Its use is associated with difficulties in preserving the resulting objects as a result of their death in the early stages of development. The use of a culture of isolated embryos to overcome the problem of embryo death during interspecific hybridization is widely used in the selection of various crops.
EDUCATIONAL PROGRAMS OF BIOINFORMATICS AND GENOMICS BASED ON ONLINE TOOLS
Authors: Орлова Н.Г. , Орлов Ю.Л.
Published: September 2024

Развитие направлений биоинформатики, биотехнологии, применения омиксных технологий, как переход на цифровые технологии в целом (цифровизация) требует подготовки современных образовательных программ, адаптации курсов для студентов, аспирантов и молодых специалистов. Вопрос разработки учебных курсов биоинформатики связан с необходимостью адаптации обучения к профилю образования студентов и слушателей различных дисциплин с инженерным, компьютерным, естественно-научным образованием, возможностью доступа к образовательным ресурсам, и современным тенденциям распределенных компьютерных вычислений.

The development of areas of bioinformatics, biotechnology, the use of omics technologies, as a transition to digital technologies in general (digitalization) requires the preparation of modern educational programs, the adaptation of courses for students, graduate students and young professionals. The issue of developing bioinformatics training courses is related to the need to adapt training to the profile of education of students and listeners of various disciplines with engineering, computer, natural science education, the ability to access educational resources, and modern trends in distributed computing.
PHENOTYPICAL VARIABILITY OF SOLANUM LYCOPERSICUM PLANTS UNDER THE INFLUENCE OF EPIGENETIC STRESS
Authors: Серганова М.А. , Меркулов П.Ю. , Киров И.В.
Published: September 2024

Мобильные генетические элементы (транспозоны) – последовательности ДНК, которые могут перемещаться внутри генома. Многочисленными исследованиями показано, что транспозоны являются факторами фенотипической изменчивости. Так, например, различные морфотипы Brassica rapa [1] и появление других агрономически ценных признаков у различных видов растений опосредовано транспозиционной активностью мобильных элементов, что делает перспективным изучение данных последовательностей не только с фундаментальной, но и с практической точки зрения. Было показано, что ретротранспозоны семейства Rider способствовали появлениям различных вариаций фенотипов по цвету и форме плодов в томатах Solanum lycopersicum

Mobile genetic elements (transposons) are DNA sequences that can move within the genome. Numerous studies have shown that transposons are factors of phenotypic variability. For example, different morphotypes of Brassica rapa [1] and the appearance of other agronomically valuable traits in different plant species are mediated by the transpositional activity of transposable elements, which makes it promising to study these sequences not only from a fundamental, but also from a practical point of view. Retrotransposons of the Rider family have been shown to contribute to the appearance of various phenotype variations in fruit color and shape in the tomato Solanum lycopersicum.
CHANGES IN THE LEVEL OF MALONE ALDEHYDE IN IN VIVO CORN LEAVES UNDER SALTIN WITH SODIUM CHLORIDE
Authors: Плотникова Е.В. , Анохина Г.Б.
Published: September 2024

Солевой стресс является распространенным абиотическим стрессом, ограничивающим рост, развитие и урожайность кукурузы. Кукуруза - одна из самых распространенных зерновых культур в мире, используемых в сельском хозяйстве. Механизм реакции на соль представляет собой очень сложный процесс, в котором у растений участвуют различные компоненты клетки. Поэтому очень важно выявить молекулярный механизм солеустойчивости данного вида растений. Известно, что в условиях действия различных стрессовых факторов происходит накопление малонового диальдегида (МДА). Вследствие дальнейших биохимических превращений он окисляется до диоксида углерода или вступает во взаимодействие с фосфолипидами, аминокислотами и нуклеиновыми кислотами [3].

Salt stress is a common abiotic stress that limits the growth, development and yield of corn. Corn is one of the world's most widely used agricultural crops. The mechanism of reaction to salt is a very complex process in which various components of the cell are involved in plants. Therefore, it is very important to reveal the molecular mechanism of salt tolerance of this plant species. It is known that under the action of various stress factors, malondialdehyde (MDA) accumulates. Due to further biochemical transformations, it is oxidized to carbon dioxide or interacts with phospholipids, amino acids, and nucleic acids [3].
PROFILE OF UNSATURATED FATTY ACIDS IN CELL MEMBRANES OF RHISOSPHERIC STRAINS PSEUDOMONAS PSEUDOALCALIGENES
Authors: Хитрова А.С. , Потатуркина-Нестерова Н. И.
Published: September 2024

Жирные кислоты, являясь одним из компонентов клеточной стенки бактерий, определяют некоторые физико-химические свойства и способны оказывать влияние на адаптивный потенциал микробной клетки. Динамика спектра жирных кислот клеточных мембран бактерий оказывает влияние на устойчивость к температурам, гидрофобность, адгезивную способность и колонизационные свойства.

Fatty acids, being one of the components of the bacterial cell wall, determine some physicochemical properties and are able to influence the adaptive potential of the microbial cell. The dynamics of the spectrum of fatty acids in bacterial cell membranes affects the resistance to temperatures, hydrophobicity, adhesive ability and colonization properties.
SELECTION OF THE INITIAL MATERIAL FOR THE CREATION OF CORN HYBRIDS FOR GROWING FOR GRAIN
Authors: Сотченко Д.Ю. , Сотченко Дм.Ю. , Таов А.А.
Published: September 2024

Кукуруза одна из важнейших сельскохозяйственных культур в мире. Уникальность состоит в высокой урожайности и универсальности использования. Кукуруза используется на продовольственные, кормовые, технические и медицинские цели. Зерно является сырьём для производства крупы, муки, масла, крахмала, спирта, глюкозы и многих других продуктов. Стержни початка идут на производство клея, краски, лака, картона, изоляционных прокладок, линолеума, целлюлозы, фурфурола и пр. Доля кукурузы в производстве крахмала в мире составляет около 75%.

Corn is one of the most important agricultural crops in the world. The uniqueness lies in the high yield and versatility of use. Corn is used for food, feed, technical and medical purposes. Grain is a raw material for the production of cereals, flour, butter, starch, alcohol, glucose and many other products. Cobs are used in the production of glue, paint, varnish, cardboard, insulating pads, linoleum, cellulose, furfural, etc. The share of corn in the production of starch in the world is about 75%.
PHENOTYPICAL MARKERS OF WINTER DURUM WHEAT SELECTION FOR FROST RESISTANCE
Authors: Яновский А.С. , Мудрова А.А. , Воропаева А.Д.
Published: September 2024

Твердая пшеница Triticum durum Desf. до начала селекционной работы была представлена в основном яровыми и слабоморозостойкими полуозимыми формами. Озимый образ жизни твердой пшеницы давно привлекал внимание земледельцев, так как во многих районах, в случае благоприятной перезимовки, урожай ее при осеннем посеве был выше, чем при весеннем.

Durum wheat Triticum durum Desf. before the start of breeding work, it was represented mainly by spring and slightly frost-resistant semi-winter forms. The winter way of life of durum wheat has long attracted the attention of farmers, since in many regions, in the event of a favorable overwintering, its yield during autumn sowing was higher than during spring.
АЛЛЕЛЬНОЕ СОСТОЯНИЕ ВЫСОКОМОЛЕКУЛЯРНЫХ ГЛЮТЕНИНОВ В СВЯЗИ С КАЧЕСТВАМИ ЗЕРНА ЯРОВОЙ ПШЕНИЦЫ (TRITICUM AESTIVUM L.)
Authors: Наджодов Б.Б. , Рубец В.С. , Пылнев В.В. , Груздев И.В.
Published: September 2024

Пшеница – хлебная культура (Bhullar et al. 2009), один из важных пищевых злаков, используемый для производства хлеба (Wieser et al.2006; Koehle et al. 2013) и является наиболее широко возделываемых культур, играет очень важную роль для обеспечение продовольственной безопасностей во всем мире. Тенденция снижение высококачественного зерна пшеницы во всем мире открывает широкие перспективы (Чебатарева и др. 2022).
ВЛИЯНИЕ ЭКСПРЕССИИ ГЕТЕРОЛОГИЧНОЙ Δ9-ДЕСАТУРАЗЫ НА ЖИРНОКИСЛОТНЫЙ СОСТАВ ЛИСТЬЕВ ТОМАТОВ
Authors: Миловская И.Г. , Варламова Н.В. , Стариков А.Ю. , Павленко О.С. , Тюрин А.А. , Соболев Д.С. , Халилуев М.Р. , Голденкова-Павлова И.В.
Published: September 2024

Для получения трансгенных растений томата (Solanum lycopersicum), экспрессирующих Δ9 ацил-липидную десатуразу цианобактерии (desC), и оценки влияния данной десатуразы на жирнокислотный (ЖК) состав суммарных липидов были сконструированы вектора, несущие ген desC.
ОПТИМИЗАЦИЯ ЭТАПА УДВОЕНИЯ ХРОМОСОМНОГО НАБОРА ГАПЛОИДНЫХ РАСТЕНИЙ МОРКОВИ СТОЛОВОЙ
Authors: Кулаков Ю.В. , Фомичева М.Г. , Чичварина О.А. , Киракосян Р.Н. , Домблидес Е.А.
Published: September 2024

Технологии удвоенных гаплоидов (DH-технологии) позволяют получать чистые линии сельскохозяйственно ценных растений за одно поколение. Однако полученные растения-регенеранты возможно использовать в селекции только в случае, если произошло удвоение ДНК, т.к. растения-гаплоиды стерильны или обладают очень ограниченной фертильностью. Для культур, у которых не происходит спонтанного удвоения ДНК, в частности, у ряда представителей семейства зонтичных (Apiaceae Lindl.), необходимо обрабатывать гаплоидные растения антимитотическими агентами, которые нарушают веретено деления, в результате чего хромосомы не расходятся, и в клетке остается двойной набор хромосом.
ДИНАМИКА LTR РЕТРОТРАНСПОЗОНОВ СУПЕРСЕМЕЙСТВА COPIA И GYPSY У РОДА CITRUS.
Authors: Боне К.Д. , Разумова О.В. , Коробкова В.А. , Дивашук М.Г. , Романов Д.В.
Published: September 2024

Общеизвестно что большая часть генома у растений состоит из повторяющей ДНК. Существуют два типа повторяющей ДНК: мобильные элементы и тандемные повторы. В свою очередь мобильные элементы делятся на ретротранспозоны и ДНК транспозоны. Мобильные элементы имеют свойства перемещаться, самовоспроизводиться и утрачиваться внутри генома.
ВИРУС-ОПОСРЕДОВАННЫЙ САЙЛЕНСИНГ ГЕНА DDM1 У ARABIDOPSIS THALIANA, ВОВЛЕЧЕННЫЙ В МЕТИЛИРОВАНИЕ ДНК
Authors: Перевозчиков Д.В. , Власова А.В. , Камараули Е.Д. , Киров И.В.
Published: September 2024

Метилирование ДНК (5mC) играет важную роль в регуляции биологических процессов и служит важнейшим механизмом эпигенетического контроля мобильных элементов растений. Особое место в метилировании ДНК растений имеет ген снижения метилирования ДНК (ddm1), кодирующий ремоделер хроматина. С его помощью обеспечивается доступ ДНК-метилтрансфераз к гетерохроматину, что позволяет стабильно подавлять мобильные элементы (Lippman et.al., 2004).
АНАЛИЗ РАЗВИВАЮЩЕЙСЯ ЗЕРНОВКИ ТРИТИКАЛЕ
Authors: Полховская Е.С.
Published: September 2024

Необходимым условием для анализа функционально значимых признаков является полная аннотация всех элементов генома (белок-кодирующие гены, промоторы, некодирующие РНК). Однако на данный момент известно, что размер генома гексаплоидной тритикале составляет около 17 Гб, в то время как около 2% генома состоит из последовательностей, кодирующих белок, а более 80% генома представлено повторяющимися последовательностями, из которых 70% являются ретроэлементами.
Shakespeare and London
Authors: Dustagheer Sarah
Published: September 2024

Shakespeare and London: A Dictionary is a topographical reference book of all the London locations, allusions and colloquial terms mentioned in Shakespeare’s complete works. For many years critics have argued that Shakespeare did not engage with the city in which he lived, however London's topography and life is present in all his work, in its language, its locations and its characters. This dictionary offers a concise and fascinating insight into the city's impact on the Shakespearean imagination and provides readers with a wide-ranging guide to early modern London, its contemporary meanings and the ways in which Shakespeare employs these throughout the canon.
Shakespeare and Science
Authors: Walker Katherine
Published: September 2024

With the recent turn to science studies and interdisciplinary research in Shakespearean scholarship, Shakespeare and Science: A Dictionary, provides a pedagogical resource for students and scholars. In charting Shakespeare’s engagement with natural philosophical discourse, this edition shapes the future of Shakespearean scholarship and pedagogy significantly, appealing to students entering the field and current scholars in interdisciplinary research on the topic alongside the non-professional reader seeking to understand Shakespeare’s language and early modern scientific practices.

Shakespeare’s works respond to early modern culture’s rapidly burgeoning interest in how new astronomical theories, understandings of motion and change, and the cataloging of objects, vegetation, and animals in the natural world could provide new knowledge. To cite a famous example, Hamlet’s letter to Ophelia plays with the differences between the Ptolemaic and Copernican notions of the earth’s movement: “Doubt that the sun doth move” may either be, in the Ptolemaic view, an earnest plea or, in the Copernican system, a purposeful equivocation. The Dictionary contextualizes such moments and scientific terms that Shakespeare employs, creatively and critically, throughout his poetry and drama. The focus is on Shakespeare’s multiform uses of language, rendering accessible to students of Shakespeare such terms as “firmament,” “planetary influence,” and “retrograde.”
Is there added value of the hepatobiliary phase of MRI with hepatobiliary contrast agents for hepatocellular carcinoma diagnosis? A meta-analysis
Authors: Rybczynska Dorota , Markiet Karolina , Pienkowska Joanna , Frydrychowski Andrzej
Published: September 2024

Purpose

So far, there have been published several meta-analyses which focused on hepatocellular carcinoma (HCC) detection with hepatobiliary phase (HBP) contrast agents. However, only a few of them aimed at establishing whether there is any added value of the HBP itself for HCC diagnosis. To answer the question, we performed a systematic literature search with the time limit going back to 2010.

Material and methods

True positive, false positive, false negative, and true negative values with and without the HBP were extracted from the included studies. Pooled sensitivities and specificities with and without the HBP were calculated and summary receiver operating characteristics curves were drawn to assess the diagnostic performance of the studies with and without the HBP.

Results

A total of 13 studies were included involving 1184 HCC lesions. In 13 studies without the HBP, the pooled sensitivity, specificity, and area under the curve (AUC) were 0.83, 0.89 and 0.94 respectively. In 13 studies with the HBP, the pooled sensitivity, specificity and AUC were 0.91, 0.85 and 0.98 respectively.

Conclusions

We found no statistically significant differences in sensitivities between studies with and without the HBP (p = 0.1651).
Hesitancy to COVID-19 Vaccine Among Healthcare Workers: A Scoping Review
Authors: Abdul Kadir Azidah , Ying Ying Ng
Published: September 2024

Vaccine hesitancy is a global concern and a significant barrier to vaccine uptake. Healthcare workers (HCWs) are more likely to contract COVID-19 and are the most trusted source of patient vaccine-related information. This scoping review summarized the rates of hesitancy against COVID-19 vaccine and booster dose among HCWs. We also explored the determinants of COVID-19 vaccine hesitancy and acceptance. The review method was described according to the PRISMA extension for scoping reviews. Literature search from PubMed, Google Scholar, Scopus, and EBSCOhost was conducted for studies published from January 2020 to August 2022. Themes were generated using inductive and deductive methods to identify the determinants for hesitancy and acceptance of COVID-19 vaccine. Overall, a total of 157 articles were included in this review. The hesitancy rate varied before the COVID-19 vaccination rollout ranging from 3.8% to 79.0%, while the hesitancy rate was 1.1%-73.3% in studies conducted after the vaccination rollout. Six themes were generated for hesitancy and seven themes for acceptance of COVID-19 vaccines. The themes identified for vaccine hesitancy and acceptance were trust issues in vaccines or authority; vulnerability to COVID-19 infection and its complications; information and misinformation; personal and past vaccine experience; religious and ethical; and socio-demographic and work factors. Professional integrity was the additional theme for vaccine acceptance. Safety and effectiveness issues, trust, perceived risk of infection, and misinformation were among the common factors. It is recommended that the government develops strategies, guidelines, or more transparent information about the vaccines to improve the acceptance of COVID-19 vaccinations.
Monkeypox: A Rising Threat
Authors: Choudhury Shimmi Sadia
Published: September 2024

Monkeypox (mpox) has recently emerged as a global health emergency. This zoonotic disease is caused by the monkeypox virus (MPXV), an enveloped double-stranded DNA virus belonging to the Orthopoxvirus genus in the Poxviridae family, which also includes viruses such as variola (smallpox), cowpox, and vaccinia. The monkeypox virus is part of the same family as the virus that causes smallpox.
Cola Saves My Life: The Successful Treatment of Oesophageal Food Bolus Impaction with Cola Ingestion
Authors: Honey Ohn May , Maung Ohn Khin
Published: September 2024

Oesophageal food bolus impaction, a serious emergency, requires immediate intervention to prevent complications, such as perforation or aspiration leading to respiratory distress. Severity varies based on factors such as the size of the ingested object, obstruction site, individual health, and the promptness of medical attention. In this report, we present the case of a middle-aged gentleman who presented to the emergency department with oesophageal food obstruction caused by a piece of lamb meat. Despite the initial unsuccessful attempts with first aid treatment, the patient experienced immediate relief of obstruction upon ingesting cola. This case highlights the potential use of cola in managing selected cases of oesophageal food impaction, offering a non-invasive alternative to oesophago-duodenoscopy. While cola emerged as a promising intervention in this case, its broader applicability and safety warrant further investigation through controlled trials. Establishing judicious cola use guidelines alongside traditional interventions can enhance patient care and safety.
To evaluate the association between T1DM in offspring with a positive parental history of diabetes
Authors: Syed Jamal Raza  , Muhammad Ali  , Jaida Manzoor  , Khan Waqas Imran , Sabahat Amir  , Ibrahim Mohsina Noor , Chandio Navira , Tariq Danish Shah , Junaid Nabeea
Published: September 2024

STRUCTURED ABSTRACT
Objective: The aim of this study was to measure the association between parental history of diabetes and the odds of an offspring having T1DM.
Study Design: SHINE (NCT03312478) was a national, multi-center, case-control study, with a ratio of 1:2 (case: control). 
Place and Duration: The study was conducted at specialized pediatric centers for 10 months. 
Patient and Methods: Three hundred and seventy-five (125 cases and 250 controls) participants were enrolled in this study. Individuals aged ≥ 2 years and ≤ 20 years with T1DM and who were on insulin for the last 1 year and positive for one or more islet cell autoantibodies were included in the study.  Primary data was collected at the time of enrolment. Participants were then contacted telephonically after 15 days for follow-up.
Results: 58% (n=218) of participants were males (mean age 10.66 [3.4] years; mean HbA1c 7.05 [2.78]). 11% (n=14) of the cases were reported to have a family history of diabetes (T2DM 10.4% [n=13]; T1DM 0.8% [n=1]). Regarding the parental history of diabetes, 8% (n=10) mothers reported having diabetes as compared to 3.2% (n=4) fathers. No statistically significant association (p= 0.83, OR= 0.92, 95% CI: 0.404 -2.077) was observed between parental history of diabetes and the odds of an offspring being T1DM.
Conclusion: The results of the study suggest no association between parental diabetic history and odds of occurrence of T1DM in offspring in a Pakistani cohort.
The role of immature granulocytes in the early diagnosis of pneumonia developing secondary to rib fractures
Authors: Dal İsmail , Gülten Sedat
Published: September 2024

Aims: This retrospective study aimed to investigate the role of immature granulocytes (IGs) in the early diagnosis of pneumonia secondary to rib fractures.
Methods: This study was conducted on patients who applied to the emergency department of our hospital between 2019 and 2022. Patients aged between 18 and 100 years who were found to have rib fractures in the thorax CT report and were hospitalized, who had hemogram data in the hospital’s database, were included in the study. Patients with detected COVID-19 infection without hemogram data and patients who refused examination and treatment were excluded from the study. Patients’ blood tests, radiological images, and epicrisis reports were analyzed. The data of patients with and without pneumonia were compared statistically.
Results: Overall, 155 patients, 117 men and 38 women were included in the study. Pneumonia developed in 11 patients, and two patient died. In our study, it was determined that the risk of pneumonia increased by 38% in each additional rib fracture, and the risk of pneumonia increased 9.44 times if the IG value at the 48th hour was greater than 0.06. In addition, when the receiver operating characteristic curves in our study were examined, it was observed that the IG number at 48 hours gave excellent results in the diagnosis of pneumonia, with 75% sensitivity and 88% specificity (cut off: 0.055, AUC: 0.827, p = 0.002).
Conclusion: Our study showed that IGs are an effective marker in the early diagnosis of pneumonia secondary to rib fractures.
Evaluation of hematological markers and disease activity in relapsing-remitting multiple sclerosis
Authors: Kocatürk İdris , Bildirici Mehmet Akif
Published: September 2024

Aims: Multiple sclerosis (MS) is an immune-mediated chronic disease of the central nervous system that causes demyelination and neuroaxonal damage. Systemic inflammation is thought to cause chronic neurodegeneration. It plays an essential role in the pathogenesis of MS. This study aims to compare the inflammatory parameters such as neutrophil-lymphocyte ratio (NLR), monocyte-lymphocyte ratio, platelet-lymphocyte ratio (PLR), systemic immune-inflammatory index (SII) and systemic inflammatory response index (SIRI) in relapsing-remitting multiple sclerosis (RRMS) patients during relapse and remission periods with the healthy control group and to investigate the relationship between these parameters and disease activity in MS patients.
Methods: This study involved one hundred four patients between the ages of 18 and 47 who applied to Kastamonu Training
and Research Hospital with an MS attack and were diagnosed with RRMS according to the 2017 McDonald criteria were
included in the study. The patients’ hemogram results were compared in the relapse and remission periods. In addition, the
hemogram results in the relapse and remission periods were compared with the hemogram results of the healthy control group.
Results: A total of 104 MS patients and 64 healthy controls were included in the study. 70 (67%) of MS patients were female,
and 24 (33%) were male. The average disease duration of the patients was calculated as 4.7±3.7, and the average Expanded
Disability Status Scale score was 2.17. NLR, PLR, SIRI, and SII were significantly higher during the attack period compared
to the healthy group. Also, NLR, PLR, SII, and SIRI were significantly higher in the remission period compared to the healthy
control group. However, there was no significant difference in NLR, PLR, SII, and SIRI levels in MS patients between the attack and remission phases.
Conclusion: Elevated inflammatory markers in MS patients compared to healthy controls suggest inflammation’s role in the
disease. Notably, similar levels during relapse and remission periods may indicate possible chronic inflammation. Larger
prospective studies are needed to confirm these findings.
Predicting The Intention for Waqf Education Among Polytechnic Staff in Malaysia
Authors: Md Nor Md Nazri , Ishak Nor Syahidah , Khairudin Nurulhuda
Published: September 2024

Waqf education is a unique model and an innovation of the Islamic social finance system. It is considered a promising platform to overcome economic inequality and enhance the wellbeing of the people in many areas, including socio-economic, education, and health. Therefore, it is necessary to analyses the underlying factors that can influence waqf education contribution among the public. This research summaries the findings of a survey on the determinant’s factors of waqf education contribution intention from the perspective of Malaysian Polytechnic’s staff. The empirical factors found were attitude, subjective norm, perceived behavioral control, knowledge, and religiosity. Malaysian Premier Polytechnic were chosen as research population namely Polytechnic Premier Ungku Omar, Polytechnic Premier Sultan Salahuddin Abdul Aziz Shah (PSA) and Polytechnic Premier Ibrahim Sultan (PIS). A survey was conducted and data from 180 respondents from various backgrounds received. An analysis was carried out to test the relationship between independent variables as well as leaning variables. The analysis was conducted using non-parametric tests namely Kruskal Wallis H-Test. Based on the obtained results, it is suggested that all independent variables, namely attitude, subjective norms, perceived behaviour control, knowledge, and religiosity, have significant relationships with the intention to contribute waqf education. In the conclusion, the author suggests several ideas for progressing waqf education in Malaysia.
Dominik Tatarka and His Journalist Dimension
Authors: Antošová Marcela
Published: September 2024

The study focuses on the Slovak writer Dominik Tatarka and his aspect of journalism. Although he is primarily a personality who belongs to the artistic-literary space, he was also heavily involved as a journalist at one time. However, the recognition of this journalistic line remains in the background, while it had a societal impact and was a serious testimony of the writer’s turbulent opinion development, turns, and attitudes. The writer radically succumbed to the communist regime at some point in his life, but after realizing the destruction that the totalitarian regime was perpetrating, he subsequently radically moved away from these positions and became its loud critic. Naturally, these positions of opinion are also copied by his journalistic activity, the reflection of which, as we have already stated, remains somewhat in the background. The study therefore has the ambition to eliminate this deficit at least partially. Based on the research of collected journalistic texts and analytical probe into their semantic space, our goal is to make available the hitherto undisclosed semantic dimensions of his journalistic communications, put them in relationships and context and thus expand the portfolio of information about this distinctive, at that time key figure of the Slovak cultural space. With regard to the limited spatial possibilities of the contribution, we focus on Tatarka's journalistic activities in the period of the second half of the 1940s to approximately the first half of the 1950s. This is the period in which he manifested himself most strongly as a journalist and his activities in this direction took on serious social dimensions.The study aims to expand the scope of information about this prominent Slovak social and cultural figure and to contribute to a more comprehensive understanding of him. Keywords: writer, journalist, communist regime, newspaper article, journalism, print media
Development of portable diagnostic devices for early detection of zoonotic diseases: A one health approach
Authors: Francisca Chibugo Udegbe  , Ejike Innocent Nwankwo  , Geneva Tamunobarafiri Igwama  , Janet Aderonke Olaboye
Published: September 2024

The integration of blockchain technology in biomedical diagnostics offers a promising solution to the challenges of data security and privacy in infectious disease surveillance. As the digitalization of healthcare systems accelerates, the need to protect sensitive health information becomes increasingly critical. Blockchain, with its decentralized and immutable nature, provides a robust framework for ensuring the integrity and confidentiality of biomedical data. This abstract explores how blockchain technology can be leveraged to enhance data security and privacy in the context of infectious disease surveillance, where rapid and accurate data sharing is essential for effective public health responses. Infectious disease surveillance relies on the collection, analysis, and dissemination of large volumes of data, often shared across multiple institutions and geographical regions. Traditional systems for managing this data are vulnerable to breaches, unauthorized access, and data tampering, which can compromise public health efforts and patient privacy. Blockchain technology addresses these vulnerabilities by enabling secure, transparent, and tamper-proof data exchanges. Each transaction or data entry is recorded in a distributed ledger, accessible only to authorized participants, thus ensuring that the data remains secure and unaltered. Moreover, blockchain’s inherent transparency allows for real-time monitoring and auditing of data flows, which is crucial in the timely detection and response to infectious disease outbreaks. The use of smart contracts within blockchain networks further enhances the automation and efficiency of data management, ensuring that data is only accessed and shared according to predefined rules and conditions. This not only safeguards patient privacy but also builds trust among stakeholders, including patients, healthcare providers, and public health authorities. In conclusion, the integration of blockchain technology in biomedical diagnostics presents a transformative approach to addressing the critical issues of data security and privacy in infectious disease surveillance. By leveraging blockchain's unique features, healthcare systems can ensure that sensitive diagnostic data is protected, thus supporting more effective and secure public health interventions in the fight against infectious diseases.
Keywords:  One Health Approach, Zoonotic Disease, Early Detection, Development, Portable Diagnostic Device.
Aspectos clave de la Nueva Gestión Pública en los procesos de Modernización y Reforma de la Administración Pública: Costa Rica y El Salvador
Authors: Rojas Rojas Johan , Carranza Cambronero Karen
Published: September 2024

The objectives of this investigation is to conduct an analysis of the paradigm of change in New Public Management, through a documentary methodology with a qualitative focus. Aspects of New Public Management in the processes of modernization and reform of public administration are analyzed through the specialized bibliography for the case study of Costa Rica and El Salvador through the application of neogerential trends, it is observed that the efficiency and quality of resources in the public administration of Costa Rica and El Salvador.
Relación entre desarrollo sostenible, economía y pobreza
Authors: Oñate Tenorio Antonio , Oñate Tenorio María de los Santos
Published: September 2024

Throughout this document, the opportunity is provided to show the relationship between sustainable development and economic growth, focusing on their definitions, their disparity and their consequences, at the same time that it gives us a vision on the evolution of the importance of economic development and of their inability to solve the problem of poverty. The satisfaction of the needs of the human being, would go through seeking a balance between economic growth, care for the environment and social welfare, a breakdown of this balance has put into question the traditional model of economic development, in which they raise fundamental questions where the very accumulation of wealth creates poverty. The bibliographic search carried out has led us to obtain a series of conclusions on the proposed terms,in which a robust social solidarity economy would lead us to the eradication of poverty. This work takes us to a reflection on the sustainability of natural resources, the viability of the economic development model and its rate of growth in a context of globalization in which localities are left behind, but without being forgotten, although they have no involvement in models that meet their development needs.
Saúde feminina integral: explorando os desafios e avanços médicos
Authors: Amaral Amanda Ribeiro , Guimarães Iris Isabela da Silva Medeiros , Vieira Lorena Marques Heck de Piau
Published: September 2024

Somos maioria. Porém únicas. Somos de fases. Porém imprevisíveis. Simples, porém complexas. Compreender e tratar de mulheres inclui compreender o feminino e a totalidade do seu mundo. O entendimento sobre as fisiologias do corpo da mulher é fundamental para o progresso do cuidar médico. Ademais compreender sobre as doenças que as afligem, as intercorrências do ciclo menstrual, envolver seu potencial reprodutivo, e enfrentar os desafios do climatério é obrigação de um médico cuidadoso. O intuito deste livro é agrupar temas essenciais durante toda a vida da mulher, incluindo seus pormenores. Destina-se a oferecer orientações de maneira que o médico consiga conduzir com segurança o cuidado integral com a saúde feminina.
Posttraumatic stress disorder, depressive and cardiovascular disease symptoms among young patients receiving medical treatment in a heart centre: A cross-sectional study
Authors: Chen Yoke Yong , Ghazali Siti Raudzah , Said Asri
Published: September 2024

Introduction: Exploring the connections between traumatic experiences and subsequent health outcomes is vital for informing clinical practices and public health policies. The study aimed to investigate the relationship between lifetime trauma exposure and posttraumatic stress disorder (PTSD), depressive and cardiovascular disease (CVD) symptoms.
Methods: A total of 171 patients who received treatment in a local heart centre were included in this study. Several questionnaires such as the Life Event Checklist-5, Posttraumatic Stress Disorder Checklist for DSM-5 and Patient Health Questionnaire-9 were used to measure their traumatic experiences and PTSD and depressive symptoms, respectively. Physiological measures were also examined. Data were analysed using SPSS.
Results: The chi-square test showed significant differences in the percentage of reported PTSD symptoms among the patients with CVD (24.0%), patients with kidney disease (4.3%) and patients with other health problems (7.1%). The patients with CVD reported having a significantly higher percentage of PTSD and depressive symptoms than the patients with other medical conditions. The patients with CVD who reported having PTSD symptoms had significant systolic blood pressure (SBP) and heart rate changes compared to the patients who did not. The patients who reported PTSD symptoms had a significantly shorter sleep duration than their counterparts. The SBP and diastolic blood pressure differed significantly between the patients with and without PTSD symptoms.
Conclusion: Earlier detection, prevention and intervention related to trauma exposure and PTSD symptoms are suggested to reduce the CVD risk.
UJI IN SILICO TURUNAN KUERSETIN SEBAGAI PENURUN KOLESTEROL LDL DARI KULIT JERUK MANIS (Citrus sinensis)
Authors: Komalasari Ela , Susanti  , Mardianingrum Richa
Published: September 2024

Kadar kolesterol dengan jumlah yang tinggi dapat mengakibatkan risiko penyakit tidak menular seperti jantung, stroke, dan diabetes mellitus. Senyawa kuersetin yang berasal dari kulit jeruk manis memiliki potensi sebagai penurun kadar kolesterol. Penelitian ini bertujuan untuk mencari kandidat obat dari senyawa turunan kuersetin sebagai penurun kadar kolesterol. Penelitian ini dilakukan secara in silico meliputi penambatan molekul serta simulasi dinamika molekul. Hasil penelitian ligan yang memiliki interaksi stabil yaitu Tamarixetin dengan nilai ikatan total pada MM-GBSA -19,24 kkal/mol dibandingkan dengan senyawa pembanding atorvastatin sebesar 16,73 kkal/mol. Dapat disimpulkan ligan Tamarixetin diprediksi dapat digunakan sebagai obat penurun kadar kolesterol dan Tamarixetin memiliki nilai energi bebas ikatan total (∆GTOTAL) -19,24 kkal/mol yang lebih rendah dibandingkan dengan senyawa Quercetin-3-O-α-D- arabinofuranosid  dan obat pembanding atorvastatin, sehingga Tamarixetin lebih baik sebagai kandidat obat penurun kadar kolesterol.
High cholesterol levels can lead to non-communicable diseases such as heart disease, stroke, and diabetes mellitus. Quercetin compounds derived from sweet orange peel have potential as cholesterol-lowering agents. This study aims to find drug candidates from quercetin derivatives as cholesterol-lowering agents. The research was conducted in silico, including molecular docking and molecular dynamics simulations. The results showed that the ligand with stable interactions was Tamarixetin, with a total binding energy value of -19.24 kcal/mol compared to the comparator compound atorvastatin, which has a value of 16.73 kcal/mol. It can be concluded that Tamarixetin is predicted to be used as a cholesterol-lowering drug, and Tamarixetin has a lower total free binding energy (∆GTOTAL) of -19.24 kcal/mol compared to Quercetin-3-O-α-D-arabinofuranoside and the comparator drug atorvastatin, making Tamarixetin a better candidate for a cholesterol-lowering drug.
CÂNCER DE MAMA E LINFEDEMA EM MULHERES MENOPAUSADAS
Authors: Saraiva Nayane Carla Soares , Mata Mayara Nicoletti Santos da , Rocha Sara Mendes , Couto Ester Resende Chicri , Barbosa Tiago Figueiredo
Published: September 2024

Introdução: O câncer de mama é uma das neoplasias mais comuns entre mulheres, especialmente em populações menopausadas, cuja incidência aumenta com a idade. O tratamento dessa condição frequentemente envolve a mastectomia e a radioterapia, procedimentos que podem desencadear o linfedema, uma condição caracterizada pelo acúmulo de linfa nos tecidos, levando a inchaço e desconforto. Objetivo: Analisar a relação entre câncer de mama e linfedema em mulheres menopausadas, destacando as implicações clínicas, as estratégias de tratamento e a gestão da condição para melhorar a qualidade de vida dessas pacientes. Metodologia: A metodologia seguiu o checklist PRISMA e envolveu a busca em quatro bases de dados: PubMed, Scielo, Web of Science e a inclusão de cinco descritores principais: “câncer de mama”, “linfedema”, “menopausa”, “tratamento” e “qualidade de vida”. Artigos publicados nos últimos 10 anos foram revisados para garantir a inclusão das pesquisas mais recentes e relevantes. Foram aplicados os seguintes critérios de inclusão: estudos que abordaram mulheres menopausadas com câncer de mama e linfedema, artigos que discutiram estratégias de manejo e tratamento do linfedema, e pesquisas que incluíram dados clínicos ou qualitativos sobre a qualidade de vida das pacientes. Os critérios de exclusão foram: artigos não relacionados especificamente ao linfedema em mulheres menopausadas, estudos focados em outros tipos de câncer ou condições não relacionadas, e publicações com dados desatualizados ou metodologias questionáveis. Resultados: Os resultados revelaram que a incidência de linfedema em mulheres menopausadas com câncer de mama pode ser significativa, com variações dependendo dos métodos de tratamento. O manejo do linfedema envolve técnicas de drenagem linfática, uso de compressão e fisioterapia. Estudos indicaram que a intervenção precoce e o monitoramento contínuo são cruciais para minimizar os sintomas e melhorar a qualidade de vida. Além disso, a pesquisa evidenciou a necessidade de abordagens integradas que combinem tratamento físico e suporte psicológico. Conclusão: Intervenções precoces e tratamentos adequados são fundamentais para controlar os sintomas e melhorar a qualidade de vida. A pesquisa sugere a necessidade de mais estudos focados em métodos de tratamento e suporte emocional para otimizar o cuidado dessas pacientes.
Improvement of Budgeting and the Success of Management Accounting: An Empirical Study
Authors:   EBS University of Business and Law, Nasca Deborah , Wald Andreas ,   University of Agder, Munck Jan Christoph ,   EBS University of Business and Law, Gleich Ronald ,   Frankfurt School of Finance and Management
Published: September 2024

Traditional budgeting approaches may be inadequate for dynamic and complex business environments, which require high budgeting flexibility and adaptability. Empirical research on the different elements of improved approaches to budgeting and their effects on management accounting success is scarce. This study identifies shared elements of improved budgeting in the literature and tests whether and to what extent they contribute to management accounting success. A research model is tested by applying partial least squares-structural equation modelling to data collected from a cross-industry survey of 189 companies. The results show that simplicity, flexibility, and integration are elements of improved budgeting that promote management accounting success. Additionally, the extent of digital transformation mediates the positive effect of flexibility on budgeting.
EDUCAÇÃO MORAL E CÍVICA: A INTERVENÇÃO DO ESTADO NA PRODUÇÃO DOS LIVROS DIDÁTICOS POR MEIO DA COLTED E DO INL NOS ANOS DE 1965 A 1975
Authors: Mendes Beatriz Moura , Damasceno Alberto , Vasconcelos Jessica Mesquita
Published: September 2024

Este artigo investiga a intervenção do Estado na produção dos livros didáticos da disciplina Educação Moral e Cívica (EMC) por meio da Comissão do Livro Técnico e do Livro Didático (COLTED) entre os anos de 1965 à 1975. Temos como objetivos analisar essa interferência estatal na educação e compreender os ideais defendidos pelo Regime Militar a partir dos livros didáticos. Esta pesquisa de caráter documental tomou como fonte os livros utilizados na disciplina para desenvolver uma análise acerca dos conteúdos ali presentes, e tem como base teórica autores que abordam o mesmo campo no contexto histórico estudado. Como resultado, concluímos que os livros se tornaram instrumento de disseminação dos princípios e valores militares, (como o amor à Pátria, à família e ao trabalho) e da classe dominante por meio da COLTED.
RANKINGS ACADÊMICOS INTERNACIONAIS COMO REGULADORES DA EDUCAÇÃO SUPERIOR: UMA ANÁLISE ACERCA DOS SEUS USOS EM DELIBERAÇÕES SOBRE POLÍTICAS INSTITUCIONAIS
Authors: Martins André Dutra , Barreyro Gladys Beatriz
Published: September 2024

Nas últimas duas décadas, rankings acadêmicos internacionais ganharam relevância na educação superior global. Referências para a formulação de políticas públicas e opiniões de importantes atores no campo, essas classificações têm influenciado atividades acadêmicas e administrativas de instituições de educação superior pelo mundo. No Brasil, pesquisas têm evidenciado a presença de rankings em Planos de Desenvolvimento Institucional e em mídias universitárias; no entanto, suas consequências nos processos de tomada de decisão nas instituições ainda são pouco conhecidas. Este artigo procura contribuir com tal entendimento, analisando atas dos Conselhos Universitários da USP e da Unicamp entre 2010 e 2023. Os resultados revelam que rankings são mobilizados como fonte de autoridade externa na construção de estratégias argumentativas, alterando como diversos agentes dão sentidos à qualidade na educação superior.