bluuebunny/crossref_metadata_2025 huggingface dataset:
Approach to Design of Piezoelectric Energy Harvester for Sensors on Electric Machine Rotors
Authors: Brandl Lukas , Reuss Hans-Christian , Heidle Daniel
Published: April 2024

The reliability and efficiency of components are key aspects in the automotive industry. Electric machines become the focus of development. Thus, improvements in efficiency and reliability have gained significance. While it is established to attach sensors to the fixed parts of machines, such as stators, moving parts like rotors pose a major challenge due to the power supply. Piezoelectric generators can operate as energy harvesters on rotors and thus enable the rotor-based integration of sensors. The research in this article proposes the first approach to the design of a piezoelectric energy harvester (PEH) for an electric machine rotor dedicated to powering a wireless sensor system. After introducing the field of PEHs, the integration of the proposed device on a rotor shaft is presented. Further, a gap between the provided and needed data for the design of a PEH is identified. To overcome this gap, a method is presented, starting with the definition of the rotor shaft dimensions and the applied mechanical loads, including a method for the calculation of the imbalance of the rotor. With the first set of dimensions of the shaft and PEH, a co-simulation is performed to calculate the power output of this rotor and PEH set. The results of the simulation indicate the feasible implementation of the PEH on the rotor, providing enough energy to power a temperature sensor.
Enhancing Fish Auction with Deep Learning and Computer Vision: Automated Caliber and Species Classification
Authors: Jareño Javier , Bárcena-González Guillermo , Castro-Gutiérrez Jairo , Cabrera-Castro Remedios , Galindo Pedro L.
Published: April 2024

The accurate labeling of species and size of specimens plays a pivotal role in fish auctions conducted at fishing ports. These labels, among other relevant information, serve as determinants of the objectivity of the auction preparation process, underscoring the indispensable nature of a reliable labeling system. Historically, this task has relied on manual processes, rendering it vulnerable to subjective interpretations by the involved personnel, therefore compromising the value of the merchandise. Consequently, the digitization and implementation of an automated labeling system are proposed as a viable solution to this ongoing challenge. This study presents an automatic system for labeling species and size, leveraging pre-trained convolutional neural networks. Specifically, the performance of VGG16, EfficientNetV2L, Xception, and ResNet152V2 networks is thoroughly examined, incorporating data augmentation techniques and fine-tuning strategies. The experimental findings demonstrate that for species classification, the EfficientNetV2L network excels as the most proficient model, achieving an average F-Score of 0.932 in its automatic mode and an average F-Score of 0.976 in its semi-automatic mode. Concerning size classification, a semi-automatic model is introduced, where the Xception network emerges as the superior model, achieving an average F-Score of 0.949.
Effect of Calanus finmarchicus Hydrolysate Inclusion on Diet Attractiveness for Whiteleg Shrimp (Litopenaeus vannamei)
Authors: Bøgwald Isak , Herrig Simon , Pedersen Alice Marie , Wubshet Sileshi Gizachew , Eilertsen Karl-Erik
Published: April 2024

Shrimp feed formulations have moved towards less fish meal and more of the readily available and cheaper plant proteins. To counteract the lower attractiveness and palatability of plant proteins, feeds are supplemented with ingredients known to have chemoattractive properties that will increase feed intake. This study investigated the putative chemoattractive effect of Calanus finmarchicus hydrolysate, when used as a dietary supplement in shrimp feeds. C. finmarchicus is a zooplankton species native to the northern Atlantic Ocean and is a novel and sustainable raw material for shrimp feed products. Diet attractiveness was evaluated in a 24-day feeding trial with whiteleg shrimp (Litopenaeus vannamei) by measuring the intake of 12 diets with various levels of fish meal, calanus hydrolysate, and krill (Euphausia superba) meal. Higher inclusion rates of both ingredients resulted in increased feed intake, and supplementing the high fish meal diet with calanus hydrolysate gave a statistically significant higher feed intake. Low molecular weight peptides, chemoattractive amino acids, and the water-soluble nature of the hydrolysate could explain the chemoattractive properties observed in the study.
Specificity of the AMP-6000 Method for Enumerating Clostridium Endospores in Milk
Authors: Burtscher Johanna , Rudavsky Tamara , Zitz Ulrike , Domig Konrad J.
Published: April 2024

Enumeration of endospores of butyric acid-forming clostridia in cheese milk is an essential part of milk quality monitoring for cheese producers to avoid late blowing, severe spoilage caused by clostridia during ripening. However, due to the lack of an internationally standardized method, different methods are used and it is important to consider how the choice of method affects the results. This is particularly relevant when clostridial spore counts in milk are considered for quality payments. The aim of this study was to evaluate the specificity of the AMP-6000 method for the enumeration of endospores of cheese spoiling clostridia in milk. First, to assess the prevalence of Clostridium diversity and to determine potential non-target species, we identified isolates from positive reactions of the AMP-6000 method used to quantify clostridial endospores in raw milk and teat skin samples by MALDI-TOF MS. Based on these results, a strain library was designed to evaluate method inclusivity and exclusivity using pure cultures of target and non-target strains according to ISO 16140-2:2016. Most target Clostridium tyrobutyricum strains, as well as all tested C. butyricum and C. sporogenes strains were inclusive. However, C. beijerinckii may be underestimated as only some strains gave positive results. All non-target strains of bacilli and lysinibacilli, but not all paenibacilli, were confirmed to be exclusive. This study provides performance data to better understand the results of microbiological enumeration of butyric acid-forming clostridia in milk and serves as a basis for future methodological considerations and improvements.
The Flavor Characteristics and Metabolites of Three Commercial Dried Jujube Cultivars
Authors: Jia Yuyao , Wang Chao , Zhang Ying , Deng Wenkai , Ma Yicai , Ma Juanfang , Han Gang
Published: April 2024

To understand the flavor and metabolite differences between the three commercial dried jujube cultivars Huizao (HZ), Hamazao 1 (HMZ), and Qiyuexian (QYX), their soluble sugars, organic acids, volatiles, and metabolites were systematically investigated. The results show that sucrose and malic acid were the main soluble sugar and organic acids contained in these dried jujubes, respectively. Sucrose (573.89 mg/g DW) had the highest presence in HZ, and the total sugar content (898.33 mg/g DW) was the highest in QYX. Both of these had a low total acid content, resulting in relatively high sugar–acid ratios (105.49 and 127.86, respectively) compared to that of HMZ (51.50). Additionally, 66 volatile components were detected in the 3 jujubes. These mainly included acids, aldehydes, esters, and ketones (90.5–96.49%). Among them, (E)-2-nonenal, (E)-2-decenal, heptanal, decanal, nonanal, and octanal were identified as the key aromatic substances of the dried jujubes, and their contents were the highest in HMZ. Moreover, 454 metabolites were identified, including alkaloids, amino acids, flavonoids, lipids, nucleotides, and terpenoids. The highest contents of flavonoids (5.6%) and lipids (24.9%) were detected in HMZ, the highest contents of nucleotides (10.2%) and alkaloids (27%) were found in QYX, and the contents of saccharides (5.7%) and amino acids (23.6%) were high in HZ. Overall, HZ, HMZ, and QYX significantly differ in their flavor and nutrition. HZ tastes better, HMZ is more fragrant, and QYX and HMZ possess higher nutritional values.
Illuminating the Characteristics and Assembly of Prokaryotic Communities across a pH Gradient in Pit Muds for the Production of Chinese Strong-Flavor Baijiu
Authors: Deng Mingdong , Hu Xiaolong , Zhang Yong , Zhang Xinyu , Ni Haifeng , Fu Danyang , Chi Lei
Published: April 2024

Pit mud (PM), as an important source of microorganisms, is necessary for Chinese strong-flavor baijiu (CSFB) production. Although it has been revealed that the PM prokaryotic community diversities are influenced by its quality, product area, ages, etc., the characteristics and assembly process of the prokaryotic community in PMs across a pH gradient are still unclear. In this study, the regular changes of α- and β-diversities of the prokaryotic community across a pH gradient in PMs were revealed, which could be divided into “stable”, “relatively stable”, and “drastically changed“ periods. A total of 27 phyla, 53 classes, and 381 genera were observed in all given samples, dominated by Firmicutes, Bacteroidetes, Proteobacteria, Lactobacillus, Caproiciproducens, Proteiniphilum, etc. Meanwhile, the complexity of the network structure of the prokaryotic microbial communities is significantly influenced by pH. The community assembly was jointly shaped by deterministic and stochastic processes, with stochastic process contributing more. This study was a specialized report on elucidating the characteristics and assembly of PM prokaryotic communities across a pH gradient, and revealed that the diversity and structure of PM prokaryotic communities could be predictable, to some degree, which could contribute to expanding our understanding of prokaryotic communities in PM.
Co-regulation of Thermosensor Pathogenic Factors by C-di-GMP-Related Two-Component Systems and a cAMP Receptor-like Protein (Clp) in Stenotrophomonas maltophilia
Authors: Ding Jieqiong , Liao Minghong , Wang Qingling
Published: April 2024

Stenotrophomonas maltophilia is a major threat to the food industry and human health owing to its strong protease production and biofilm formation abilities. However, information regarding regulatory factors or potential mechanisms is limited. Herein, we observed that temperature differentially regulates biofilm formation and protease production, and a cAMP receptor-like protein (Clp) negatively regulates thermosensor biofilm formation, in contrast to protease synthesis. Among four c-di-GMP-related two-component systems (TCSs), promoter fusion analysis revealed that clp transcription levels were predominantly controlled by LotS/LotR, partially controlled by both RpfC/RpfG and a novel TCS Sm0738/Sm0737, with no obvious effect caused by Sm1912/Sm1911. Biofilm formation in Δclp and ΔTCSs strains suggested that LotS/LotR controlled biofilm formation in a Clp-mediated manner, whereas both RpfC/RpfG and Sm0738/Sm0737 may occur in a distinct pathway. Furthermore, enzymatic activity analysis combined with c-di-GMP level indicated that the enzymatic activity of c-di-GMP-related metabolism proteins may not be a vital contributor to changes in c-di-GMP level, thus influencing physiological functions. Our findings elucidate that the regulatory pathway of c-di-GMP-related TCSs and Clp in controlling spoilage or the formation of potentially pathogenic factors in Stenotrophomonas expand the understanding of c-di-GMP metabolism and provide clues to control risk factors of S. maltophilia in food safety.
Bactericidal Effects and Quality Impact of Peroxyacetic Acid and Sodium Hypochlorite on Chicken Carcasses
Authors: Zhang Bo-Zheng , Kim Jin-Man , Park Jung-Min
Published: April 2024

There is an urgent need to develop efficient and environmentally friendly decontaminants for poultry products. In this study, we aimed to evaluate the practical application of peroxyacetic acid (PAA) as a replacement for sodium hypochlorite (SH) to sterilize fresh chicken carcasses, using microbial, color, and electronic-nose analyses. We evaluated the decontamination effects of different concentrations of PAA and SH on chicken carcasses. The bactericidal effects of PAA at pH 3, 7, and 9, and SH at pH 10, at concentrations ranging from 100 to 500 ppm on coliform bacteria, total bacteria, and Salmonella spp. were evaluated. PAA induced a similar bactericidal effect at lower concentrations than SH. Therefore, at the same concentration and treatment time, PAA showed better bactericidal effects than SH. Although treatment with PAA (pH 3) and SH (pH 10) resulted in considerable discoloration, the degree of discoloration decreased when the pH of PAA was increased to 7 and 9. Therefore, by increasing the pH of PAA, the discoloration effect on chicken carcasses can be reduced without altering the microbial-reduction effect. Electronic-nose analysis showed that the flavor of the chicken was almost unaffected by volatile components at a treatment time < 30 min. Therefore, this study experimentally identified the optimal PAA concentration for the decontamination of chicken carcasses. The study findings provide a theoretical basis for the replacement of traditional bactericides, such as SH, with PAA for the production of poultry products.
A Fractional-Order Archimedean Spiral Moth–Flame Optimization Strategy to Solve Optimal Power Flows
Authors: Wadood Abdul , Ahmed Ejaz , Rhee Sang Bong , Sattar Khan Babar
Published: April 2024

This research utilizes the innovative fractional-order Archimedean spiral moth–flame optimization (FO-AMFO) technique to address the issues of the optimal reactive power dispatch (ORPD) problem. The formulated fitness function aims to minimize power losses and determine the ideal flow of reactive power for the IEEE 30- and 57-bus test systems. The extensive functions of the fractional evolutionary computing strategy are utilized to address the minimization problem of ORPD. This involves determining the control variables, such as VAR compensators, bus voltages, and the tap setting of the transformers. The effective incorporation of reactive compensation devices into traditional power grids has greatly reduced power losses; however, it has resulted in an increase in the complexity of optimization problems. A comparison of the findings indicates that swarming fractional intelligence using FO-AMFO surpassed the state-of-the-art competitors in terms of minimizing power losses.
Shedding a Light on Dark Genes: A Comparative Expression Study of PRR12 Orthologues during Zebrafish Development
Authors: Muscò Alessia , Martini Davide , Digregorio Matteo , Broccoli Vania , Andreazzoli Massimiliano
Published: April 2024

Haploinsufficiency of the PRR12 gene is implicated in a human neuro-ocular syndrome. Although identified as a nuclear protein highly expressed in the embryonic mouse brain, PRR12 molecular function remains elusive. This study explores the spatio-temporal expression of zebrafish PRR12 co-orthologs, prr12a and prr12b, as a first step to elucidate their function. In silico analysis reveals high evolutionary conservation in the DNA-interacting domains for both orthologs, with significant syntenic conservation observed for the prr12b locus. In situ hybridization and RT-qPCR analyses on zebrafish embryos and larvae reveal distinct expression patterns: prr12a is expressed early in zygotic development, mainly in the central nervous system, while prr12b expression initiates during gastrulation, localizing later to dopaminergic telencephalic and diencephalic cell clusters. Both transcripts are enriched in the ganglion cell and inner neural layers of the 72 hpf retina, with prr12b widely distributed in the ciliary marginal zone. In the adult brain, prr12a and prr12b are found in the cerebellum, amygdala and ventral telencephalon, which represent the main areas affected in autistic patients. Overall, this study suggests PRR12’s potential involvement in eye and brain development, laying the groundwork for further investigations into PRR12-related neurobehavioral disorders.
FOXP3: A Player of Immunogenetic Architecture in Lung Cancer
Authors: Ziółkowska-Suchanek Iwona , Żurawek Magdalena
Published: April 2024

The transcription factor forkhead box protein 3 (FOXP3) is considered to be a prominent component of the immune system expressed in regulatory T cells (Tregs). Tregs are immunosuppressive cells that regulate immune homeostasis and self-tolerance. FOXP3 was originally thought to be a Tregs-specific molecule, but recent studies have pinpointed that FOXP3 is expressed in a diversity of benign tumors and carcinomas. The vast majority of the data have shown that FOXP3 is correlated with an unfavorable prognosis, although there are some reports indicating the opposite function of this molecule. Here, we review recent progress in understanding the FOXP3 role in the immunogenetic architecture of lung cancer, which is the leading cause of cancer-related death. We discuss the prognostic significance of tumor FOXP3 expression, tumor-infiltrating FOXP3-lymphocytes, tumor FOXP3 in tumor microenvironments and the potential of FOXP3-targeted therapy.
Exploring the Potential Impact of Training on Short-Term Quality of Life and Stress of Parents of Children with Autism: The Integrative Parents’ Autism Training Module
Authors: Mavroeidi Nikoletta , Sifnaios Christos , Ntinou Ariadne , Iatrou Giorgos , Konstantakopoulou Olympia , Merino Martínez María , Nucifora Martina , Tanrikulu Ibrahim , Vadolas Antonios
Published: April 2024

Parents of autistic children experience high levels of parental stress and low quality of life related to the demanding child caring burden they experience. Parent education and training programs are acknowledged to improve parental well-being and reduce parenting stress. In the framework of the Erasmus+ Integrative Autism Parents Training Project (IPAT), we developed the IPAT Training Module based on parents’ expressed needs, in order to improve parental quality of life (QoL) and decrease their perceived stress. Sixty-two parents from four countries participated in the IPAT Module Training activity. We used WHOQOL-BREF and Perceived Stress Scale (PSS-10 version) for QoL and stress, respectively, before and after training and a study-specific questionnaire to assess participants’ satisfaction. Parents’ QoL improved significantly in the environment domain and specific items, while stress levels remained unmodified. Training appeared more advantageous for parents with lower initial QoL and those whose child had been enrolled in a special education program for an extended duration. Parents were quite satisfied, in particular those with lower initial social relationships QoL. Larger studies including a control group are necessary to support preliminary evidence provided by this study, identify additional effect moderators, and disentangle the contribution of different components of the training.
Characteristics and Circumstances of Adolescents Obtaining Abortions in the United States
Authors: Chiu Doris W. , Braccia Ava , Jones Rachel K.
Published: April 2024

The purpose of this study is to describe the sociodemographic and situational circumstances of adolescents obtaining abortion in the United States prior to the Dobbs decision. We use data from the Guttmacher Institute’s 2021–2022 Abortion Patient Survey, a cross-sectional survey of 6698 respondents; our analytic sample includes 633 adolescents (<20 years), 2152 young adults (20–24 years), and 3913 adults (25+ years). We conducted bivariate analyses to describe the characteristics and logistical and financial circumstances of adolescents obtaining abortions in comparison to respondents in the other age groups. The majority of adolescents identified as non-white (70%), and 23% identified as something other than heterosexual. We found that 26% of adolescents reported having no health insurance, and two-thirds of adolescent respondents reported that somebody had driven them to the facility. Adolescents differed from adults in their reasons for delays in accessing care; a majority of adolescents (57%) reported not knowing they were pregnant compared to 43% of adults, and nearly one in five adolescents did not know where to obtain the abortion compared to 11% of adults. Adolescents were more likely than adults to obtain a second-trimester abortion, which has increased costs. This study found that this population was more vulnerable than adults on several measures. Findings suggest that adolescents navigate unique barriers with regard to information and logistics to access abortion care.
Study Circles as a Possible Arena to Support Self-Care—A Swedish Pilot Study
Authors: Kerstis Birgitta , Herlofson Jorgen , Wiklund Gustin Lena
Published: April 2024

Today, issues related to people’s mental health and well-being have been described as a challenge for society, globally as well as in Sweden. This calls for new approaches to mental health promotion. The aim was to evaluate the adequacy of its content and structure, describing experiences of study circles as a means of supporting participants’ self-care and self-compassion. The overall design is a descriptive QUAL + quan design, where the quantitative and qualitative results are integrated. Five participants participated in a focus group interview, of whom four completed questionnaires. One individual interview was conducted with the study circle leader. Study circles can be an arena for mental health promotion, as learning and sharing of experience contributes to a sense of coherence, as well as self-compassion and a genuine concern for one’s own and others’ well-being, but are not considered an alternative to psychiatric care for those in need of professional services. Study circles can be a possible means to support self-care and thereby promote mental health in the general population and are a valuable contribution to public health. However, in addition to modifications of the content, further research is needed on the qualifications for study circle leaders, as well as the dissemination of study circles.
Spatial Relationship of Inter-City Population Movement and Socio-Economic Determinants: A Case Study in China Using Multiscale Geographically Weighted Regression
Authors: Liu Sihan , Niu Xinyi
Published: April 2024

In the current field of regional studies, there is a growing focus on regional spatial relationships from the perspective of functional linkages between cities. Inter-city population movement serves as an embodiment of the integrated functionality of cities within a region, and this is closely tied to the socio-economic development of urban areas. This study utilized Location-Based Services (LBSs) to collect the scale of inter-city population movement across 355 cities in China. Additionally, socio-economic data published by local governments were incorporated. By establishing a Multiscale Geographically Weighted Regression (MGWR) model, this research explores the spatial relationships between inter-city population movement and socio-economic influencing factors in China. This study aims to elucidate the spatial scales of the relationships between various variables. Our research findings indicate that the relationship between inter-city population movement and potential socio-economic determinants exhibits spatial non-stationarity. It is better to explore this spatial relationship through the MGWR model as there are different determinants operating on inter-city population movement at different spatial scales. The spatial distribution of the coefficient estimates shows significant regional differences and numerical variations. In China’s economically developed coastal regions, there is relatively balanced development among cities, with advanced manufacturing and producer service industries acting as significant drivers of mobility. In inland regions of China, city size is the most influential variable, directing a substantial flow of human and economic resources towards regional socio-economic hubs such as provincial capitals. The main contribution of this study is the re-examination of the relationship between inter-city population movement and socio-economic factors from the perspective of spatial scales. This approach will help China to consider the heterogeneity of different regions more extensively when formulating regional development policies, thereby facilitating the targeted promotion of regional element flow.
Variations in Pattern of Social Media Engagement between Individuals with Chronic Conditions and Mental Health Conditions
Authors: Ayangunna Elizabeth , Shah Gulzar , Kalu Kingsley , Shankar Padmini , Shah Bushra
Published: April 2024

The use of the internet and supported apps is at historically unprecedented levels for the exchange of health information. The increasing use of the internet and social media platforms can affect patients’ health behavior. This study aims to assess the variations in patterns of social media engagement between individuals diagnosed with either chronic diseases or mental health conditions. Data from four iterations of the Health Information National Trends Survey Cycle 4 from 2017 to 2020 were used for this study with a sample size (N) = 16,092. To analyze the association between the independent variables, reflecting the presence of chronic conditions or mental health conditions, and various levels of social media engagement, descriptive statistics and logistic regression were conducted. Respondents who had at least one chronic condition were more likely to join an internet-based support group (Adjusted Odds Ratio or AOR = 1.5; Confidence Interval, CI = 1.11–1.93) and watch a health-related video on YouTube (AOR = 1.2; CI = 1.01–1.36); respondents with a mental condition were less likely to visit and share health information on social media, join an internet-based support group, and watch a health-related video on YouTube. Race, age, and educational level also influence the choice to watch a health-related video on YouTube. Understanding the pattern of engagement with health-related content on social media and how their online behavior differs based on the patient’s medical conditions can lead to the development of more effective and tailored public health interventions that leverage social media platforms.
Functionalization of Na2Ca2Si3O9/Ca8Si5O18 Nanostructures with Chitosan and Terephthalaldehyde Crosslinked Chitosan for Effective Elimination of Pb(II) Ions from Aqueous Media
Authors: Al-Farraj Eida S. , Alotaibi Abdullah N. , Abdelrahman Ehab A. , Saad Fawaz A. , Rehman Khalil ur , Algethami Faisal K. , Shah Reem K.
Published: April 2024

Lead poses significant health risks to humans, including neurological and developmental impairments, particularly in children. Additionally, lead pollution in the environment can contaminate soil, water, and air, endangering wildlife and ecosystems. Therefore, this study reports the straightforward fabrication of Na2Ca2Si3O9/Ca8Si5O18 nanostructures (NaCaSilicate) utilizing a sol-gel technique. Additionally, the produced nanostructures underwent further modification with chitosan (CS@NaCaSilicate) and chitosan crosslinked with terephthalaldehyde (CCS@NaCaSilicate), resulting in new nanocomposite materials. These samples were developed to efficiently extract Pb(II) ions from aqueous media through complexation and ion exchange mechanisms. Furthermore, the maximum adsorption capacity for Pb(II) ions by the NaCaSilicate, CS@NaCaSilicate, and CCS@NaCaSilicate samples is 185.53, 245.70, and 359.71 mg/g, respectively. The uptake of Pb(II) ions was characterized as spontaneous, exothermic, and chemical, with the best description provided by the Langmuir equilibrium isotherm and the pseudo-second-order kinetic model. Furthermore, a 9 M hydrochloric acid solution effectively eliminated Pb(II) ions from the synthesized samples, attaining a desorption efficacy surpassing 99%. Additionally, the fabricated samples exhibited efficient reusability across five successive cycles of adsorption and desorption for capturing Pb(II) ions.
Synthesis, Spectral Characterization, and Structural Modelling of Di- and Trinuclear Iron(III) Monensinates with Different Bridging Patterns
Authors: Petkov Nikolay , Tadjer Alia , Simova Svetlana , Cherkezova-Zheleva Zara , Paneva Daniela , Stoyanova Radostina , Kukeva Rositsa , Dorkov Petar , Pantcheva Ivayla
Published: April 2024

In the present study, we report the solid-state isolation and structural characterization of novel iron(III) complexes of the veterinary antibiotic monensin. Monensic acid (MonH × H2O) forms a dinuclear complex of composition with FeCl3 [FeCl(Mon)2]2 (1), while its interaction with FeSO4 leads to the isolation of a triangular oxo-ferric coordination species [Fe3O(Mon × H2O)6(H2O)2(OH)] (2). During the procedure resulting in 2, oxidation of the Fe(II) ions by atmospheric oxygen was observed. In the presence of organic bases, both complexation reactions proceeded to successfully deprotonate the carboxylic function of the ligand. Iron(III) complexes 1 and 2 were characterized by IR, EPR, NMR, and Mössbauer spectroscopies as well as with thermal (TG-DTA/MS) and elemental analyses. In addition, the structures of the two coordination compounds were modelled and selected calculated parameters were compared with the experimental results. The biological assay revealed the enhanced antibacterial potential of the newly obtained complexes against the Gram-positive aerobic microorganisms Bacillus cereus and Bacillus subtilis.
New Biomarkers for Systemic Necrotizing Vasculitides
Authors: Shumnalieva Russka , Ermencheva Plamena , Kotov Georgi , Parvova-Hristova Iva , Bakopoulou Konstantina , Kaouri Issa El , Mileva Niya , Velikova Tsvetelina
Published: April 2024

Systemic necrotising vasculitides (SNVs) pose significant challenges due to their diverse clinical manifestations and variable outcomes. Therefore, identifying reliable biomarkers holds promise for improving precision medicine in SNVs. This review explores emerging biomarkers aiming to enhance diagnostic accuracy, prognostic assessment, and disease monitoring. We discuss recent advances in immunological biomarkers, inflammatory indicators, and other parameters that exhibit potential diagnostic and prognostic utility. A comprehensive understanding of these biomarkers may facilitate earlier and more accurate SNV detection, aiding in timely intervention and personalized treatment strategies. Furthermore, we highlight the evolving landscape of disease monitoring through innovative biomarkers, shedding light on their dynamic roles in reflecting disease activity and treatment response. Integrating these novel biomarkers into clinical practice can revolutionize the management of SNVs, ultimately improving patient outcomes and quality of life.
Long-Term Health-Related Quality of Life following Acute Type A Aortic Dissection with a Focus on Male–Female Differences: A Cross Sectional Study
Authors: Meccanici Frederike , Thijssen Carlijn G. E. , Gökalp Arjen L. , Bom Annemijn W. , Geuzebroek Guillaume S. C. , ter Woorst Joost F. , van Kimmenade Roland R. J. , Post Marco C. , Takkenberg Johanna J. M. , Roos-Hesselink Jolien W.
Published: April 2024

Objectives: Acute type A aortic dissection (ATAAD) is a life-threatening cardiovascular emergency, of which the long-term impact on health-related quality of life (HRQoL) and male–female-specific insights remain inadequately clarified. Methods: Consecutive adult ATAAD patients who underwent surgery were retrospectively included between 2007 and 2017 in four referral centers in the Netherlands, and baseline data were collected. The 36-Item Short-Form (SF-36) Health Survey was sent to all survivors between 2019 and 2021 and compared to validated SF-36 scores of the Dutch general population stratified by age group and sex. Results: In total, 324/555 surviving patients returned the SF-36 questionnaire (response rate 58%), of which 40.0% were female; the median follow-up was 6.5 years (range: 1.7–13.9, IQR: 4.0–9.4) after surgery for ATAAD. In comparison to the general population, ATAAD patients scored significantly lower on 6/8 SF-36 subdomains and higher on bodily pain. Differences in HRQoL domains compared to the sex-matched data were largely comparable between sexes, apart from bodily pain. In the age-matched subgroups impaired HRQoL was most pronounced in younger patients aged 41–60 (5/8 impaired domains). Female ATAAD patients scored significantly worse on 5/8 SF-36 subdomains and the physical component summary (PCS) scores than male patients. Age at ATAAD, female sex, hypertension, COPD, and prior thoracic aortic aneurysm were associated with worse PCS scores. Conclusions: Long-term HRQoL was impaired in both male and female ATAAD patients when compared to the general population. Further studies on the nature of this impairment and on interventions to improve HRQoL after ATAAD are clearly warranted, with special attention to females and younger patients.
Insights on the Choice and Preparation of the Donor Nerve in Corneal Neurotization for Neurotrophic Keratopathy: A Narrative Review
Authors: Serra Pietro Luciano , Giannaccare Giuseppe , Cuccu Alberto , Bolognesi Federico , Biglioli Federico , Marcasciano Marco , Tarabbia Filippo , Pagliara Domenico , Figus Andrea , Boriani Filippo
Published: April 2024

The article introduces neurotrophic keratopathy (NK), a condition resulting from corneal denervation due to various causes of trigeminal nerve dysfunctions. Surgical techniques for corneal neurotization (CN) have evolved, aiming to restore corneal sensitivity. Initially proposed in 1972, modern approaches offer less invasive options. CN can be performed through a direct approach (DCN) directly suturing a sensitive nerve to the affected cornea or indirectly (ICN) through a nerve auto/allograft. Surgical success relies on meticulous donor nerve selection and preparation, often involving multidisciplinary teams. A PubMed research and review of the relevant literature was conducted regarding the surgical approach, emphasizing surgical techniques and the choice of the donor nerve. The latter considers factors like sensory integrity and proximity to the cornea. The most used are the contralateral or ipsilateral supratrochlear (STN), and the supraorbital (SON) and great auricular (GAN) nerves. Regarding the choice of grafts, the most used in the literature are the sural (SN), the lateral antebrachial cutaneous nerve (LABCN), and the GAN nerves. Another promising option is represented by allografts (acellularized nerves from cadavers). The significance of sensory recovery and factors influencing surgical outcomes, including nerve caliber matching and axonal regeneration, are discussed. Future directions emphasize less invasive techniques and the potential of acellular nerve allografts. In conclusion, CN represents a promising avenue in the treatment of NK, offering tailored approaches based on patient history and surgical expertise, with new emerging techniques warranting further exploration through basic science refinements and clinical trials.
Sexual Dysfunction in Postural Orthostatic Tachycardia Syndrome (POTS): A Cross-Sectional, Case-Control Study
Authors: Blitshteyn Svetlana , Lange Anna , Corinaldi Chelsea , Guy Paige , Brook Jill
Published: April 2024

Background: We aimed to determine whether patients with postural orthostatic tachycardia syndrome (POTS) have sexual dysfunction compared to age-matched healthy controls. Methods: Utilizing online COMPASS-31 to evaluate dysautonomia symptom severity, Beck’s Depression Inventory Second Edition (BDII), Female Sexual Function (FSF), and International Index of Erection Function (IIEF) questionnaires, we compared sexual function scores in patients with POTS to scores obtained from sex- and age-matched healthy controls via a cross-sectional case–control study. Results: A total of 160 women with POTS, mean age 30.2 ± 7.9 (range 21–50 years), had lower FSF scores than 62 healthy age-matched female controls. IIEF scores in 29 male patients with POTS with a mean age of 30.1 ± 6.0 (range 21–47) were significantly lower than in 27 healthy age-matched male controls. Female POTS patients had significantly lower scores in the sub-domains of desire, arousal, and satisfaction, while male POTS patients had significantly lower scores in erectile and orgasmic function, desire, and satisfaction than healthy controls. Predictive factors of sexual dysfunction were depression in women and age in men. The severity of autonomic symptoms correlated with sexual dysfunction in women, but this effect disappeared after controlling for depression. Conclusions: Compared to healthy controls, women and men with POTS have significant sexual dysfunction, which needs to be considered in the diagnostic and therapeutic approaches as part of comprehensive patient care.
Reinforcement Techniques in Arthroscopic Repair of Large-to-Massive Rotator Cuff Tears: A Comparative Study of Superior Capsule Reconstruction and Patch Graft Augmentation
Authors: Yee Jae-Sung , Choi Jin-Kwan , Kim Ki-Tae , Lee Ho-Won , Lee Yong-Beom
Published: April 2024

Background: Large-to-massive rotator cuff tears (LMRCTs) present challenges in achieving successful repair due to factors such as muscle atrophy and tendon retraction. Arthroscopic rotator cuff repair (ARCR) with reinforcement techniques like superior capsule reconstruction (SCR) or patch graft augmentation (PGA) has emerged as a less invasive option to improve shoulder joint stability and prevent retear. This study aimed to compare the clinical and radiological outcomes of SCR and PGA as reinforcement techniques for the arthroscopic repair of LMRCTs. Methods: A single-center retrospective study was conducted on patients undergoing LMRCT repair between January 2019 and December 2021. Patients were divided into two groups: those receiving SCR (Group 1) and those receiving PGA (Group 2). Various clinical parameters including range of motion, functional scores, and radiological assessments were evaluated preoperatively and six months postoperatively. Results: Both SCR and PGA techniques demonstrated significant improvements in the range of motion and clinical scores postoperatively. However, Group 2 showed higher postoperative SST and UCLA scores compared to Group 1. Radiologically, there was a slightly higher retear rate in Group 2, although this was not statistically significant. Group 2 also had a shorter mean duration of surgery compared to Group 1. Conclusions: In the arthroscopic repair of LMRCTs, both SCR and PGA techniques exhibit favorable clinical and radiological outcomes. Despite the simplicity of PGA compared to SCR, it offers comparable results with a shorter surgical duration, making it a feasible reinforcement option for surgeons.
Postoperative Benefits of Soft Tissue Wrist Arthroscopy: Retro- and Prospective Analyses of Outcome Measures
Authors: Demmer Wolfram , Meyer Emanuel , Ehrl Denis , Volkmer Elias , Lukas Bernhard , Knie Nina F. , Giunta Riccardo E. , Wachtel Nikolaus
Published: April 2024

Background: Elective soft-tissue-only wrist arthroscopy is a standard procedure in hand surgery for the diagnosis and treatment of wrist pain. A number of pathologies can be treated arthroscopically, with the aim of pain reduction and improved wrist mobility. A postinterventional evaluation of the treatment using objective and patient-reported outcome measures (PROMs) allows for an evidence-based statement about the benefits of soft-tissue-only wrist arthroscopy. Methods: A dual-center study combining retro- and prospective clinical analyses of patient outcomes after soft-tissue-only wrist arthroscopies was performed. The data were collected at two hospitals with departments specializing in hand surgery. The outcome was measured by assessing the range of motion of the wrist and its manual strength, as well as PROMs, including Disabilities of the Arm, Shoulder and Hand (DASH) scores. Results: A total of 154 soft interventions met the study criteria and could be included. Seven months after the elective soft-tissue-only wrist arthroscopies, mobility improved significantly for active extension and flexion, as well as the ulnar and radial abduction of the wrist. The grip strength also improved significantly, by an average of 6 kg, during this period. The DASH score improved significantly, from 35 points to 14 points. Additionally, wrist pain at rest was reduced significantly. Conclusions: After elective soft-tissue-only wrist arthroscopy, patients showed an overall functional improvement in their wrist, with a significant reduction in pain and improvement of mobility and grip strength. This study emphasizes the importance of wrist arthroscopy as a successful treatment option for soft tissue pathologies of the wrist.
Electrochemical Deposition and Properties of Ni Coatings with Nitrogen-Modified Graphene Oxide
Authors: Tseluikin Vitaly , Dzhumieva Asel , Tribis Alena , Brudnik Sergey , Tikhonov Denis , Yakovlev Andrey , Mostovoy Anton , Lopukhova Marina
Published: April 2024

In this study, a method for producing nitrogen-modified graphene oxide (NMGO) using hydrothermal synthesis in the presence of triethanolamine is presented. The composition and structure of NMGO are characterized using X-ray phase analysis (XPA), scanning electron microscopy (SEM), Fourier transform infrared spectroscopy, and Raman spectroscopy. Ni-based metal matrix coatings (MMCs) modified with NMGO were obtained from a sulfate-chloride electrolyte in the galvanostatic mode. The process of electrochemical deposition of these coatings was studied using chronovoltammetry. The microstructure of Ni–NMGO MMCs was studied using the XPA and SEM methods. It has been established that the addition of NMGO particles into the Ni matrix results in an increase in the microhardness of the resulting coatings by an average of 1.30 times. This effect is a consequence of the refinement of crystallites and high mechanical properties of NMGO phase. The corrosion-electrochemical behavior of studied electrochemical deposits in 0.5 M sulfuric acid was analyzed. It has been shown that the corrosion rate of Ni–NMGO MMCs in a 3.5% sodium chloride environment decreases by approximately 1.50–1.70 times as compared to unmodified Ni coatings. This is due to NMGO particles that act as a barrier preventing the propagation of the corrosion and form corrosive galvanic microelements with Ni, promoting anodic polarization.
The Morphological and Thermal Characteristics of Hollow-Glass-Microsphere-Coated Phase Change Material–Cow Pie Embedded Recycled Plastic Tiles for Cool Roofs
Authors: Satya S. Krishna , Rama Sreekanth P. S.
Published: April 2024

This study addresses the global plastic waste crisis and the urban heat island effect by developing an innovative solution: recycled plastic roof tiles embedded with phase change material (PCM) and coated with hollow-glass-microsphere-based white paint. The samples were fabricated with cow pie fibers, OM37 and OM42 PCM materials with different wt./vol. values, i.e., 15/50, 20/50, 25/50, 30/50 ratios. The fabricated tiles were coated with hollow glass microspheres to provide a reflective layer. The tiles’ effectiveness was evaluated through morphological examination and thermal analysis. The SEM analysis revealed an excellent bonding ability for the PCM blend, i.e., OM37 and OM42 at a 20/50 ratio (wt./vol.) with cow pie fibers. Adding cow pie fibers to the PCM shifted the melting points of OM37 and OM42, indicating an increased heat storage capacity in both blends. The thermal conductivity results revealed decreased thermal conductivity with an increased cow pie fiber percentage. The recycled plastic roof tile of the PCM composite at a 20/50 (wt./vol.) ratio showed good thermal properties. Upon testing in real-time conditions in a physical setup, the roof tiles showed a temperature reduction of 8 °C from outdoors to indoors during the peak of summer. In winter, cozy temperatures were maintained indoors due to the heat regulation from the roof.
Temporal and Spatial Analysis of Coupling Coordination in Beijing–Tianjin–Hebei Urban Agglomeration: Ecology, Environment and Economy
Authors: Zhao Yanhong , Hou Peng , Jiang Jinbao , Zhai Jun , Chen Yan
Published: April 2024

With the rapid growth and development of urban areas, the economy has often been prioritized at the expense of the environment and ecological systems. However, it is essential to delve deeper into the relationship between the economy and the ecological environment. Therefore, this study introduces a comprehensive evaluation system that encompasses economic, ecological, and environmental factors in the Beijing–Tianjin–Hebei urban agglomeration in China. The Criteria Importance Through Inter-criteria Correlation (CRITIC) method is utilized to determine the weights of various indicators, and coupling as well as coupling coordination models are employed to investigate the spatiotemporal trends and interrelationships of the three factors. The results indicate that the economic development index has displayed a consistent uptrend since 2000, with the economic development index from 2015–2020 increasing by approximately four times compared to 2000–2005. The ecological status index has also increased in the last five years, with a rise of about 0.05 from 2015–2020 compared to 2000–2005. The environmental status index has fluctuated but generally increased, with a rise of approximately 5.6 times from 2015–2020 compared to 2000–2005. The coupling degree of the Beijing–Tianjin–Hebei urban agglomeration is relatively high, with intense coupling from 2005–2020, and moderate coupling from 2000–2005. Furthermore, the coupling coordination has continuously improved from mild maladjustment to barely coordinated from 2000 to 2020, indicating the enhancement of the coupling coordination of the three factors. It is crucial to acknowledge that there exists spatial heterogeneity in both the coupling degree and coupling coordination degree. This heterogeneity stems from the uneven progress in economic development, ecological conditions, and environmental status across various cities. Additional endeavors are required to foster the harmonized advancement of these factors across the entire region.
Change Patterns between 1993 and 2023 and Effects of COVID-19 on Tourist Traffic in Tatra National Park (Poland)
Authors: Fidelus-Orzechowska Joanna , Sitarz Magdalena , Król Maria
Published: April 2024

Tatra National Park (TNP) is one of the most popular national parks in Poland. The purpose of this study was to examine changes in the number of tourists visiting the Park each year from 1993 with a special focus on the COVID-19 period. The main part of this study focused on tourist traffic data for the period from 1993 to 2023. Daily, monthly, and annual data were examined. The source of most of the data is park entry ticket sales. The largest number of tourists entering TNP in the period of 1993–2022 was recorded in 2021 at 4,788,788. Tourist traffic in TNP is concentrated on so-called long weekends in May and June. An examination of data from 2010, 2015, and 2021 shows that tourist volumes on the long weekend of 1–3 May be up to 40 times larger than those on other weekends in May. On the other hand, long weekends in June can attract eight times more tourists relative to the average other weekends in June. The number of tourists engaging in hiking, climbing, spelunking, and ski touring declined during the COVID-19 pandemic in 2020. However, the number of ski tourers in TNP in 2021 was about four times larger than the total between 2015–2022. Data on traffic patterns are key in designing, implementing, and measuring the efficiency of solutions for sustainable management for both the peak usage periods and future patterns in tourism.