bluuebunny/crossref_metadata_2025 huggingface dataset:
The effectiveness of hepatotropic complex Lesil in prevention hepatotoxic effects of anti-helicobacter therapy
Authors: Shcherbynina M. B. , Shevchenko T. M. , Novozhenina L. I.
Published: November 2023

Objective — to evaluate the effectiveness of the hepatotropic complex Lesil® for the prevention of the development of drug‑induced liver damage in patients receiving anti‑Helicobacter therapy (AHT).
Materials and methods. Observation involved the main (I) and control (II) groups of 40 people in each. Patients with gastroduodenal diseases were included in the study if Helicobacter pylori (H. pylori) infection was first detected. A 14‑day course of 4‑component AHT was administered: pantoprazole, amoxicillin, clarithromycin, colloidal bismuth subcitrate. The main group additionally received Lesil® (Propharma Plant LLC, Ukraine) in a dose of 2 capsules a day for 6 weeks. Patients’ satisfaction with therapy was assessed using a visual analog scale. Statistical processing of the obtained results was carried out using standard methods.
Results. After the course of treatment, eradication of H. pylori was achieved in 76 subjects (95%). After the end of AHT in the I group, no changes in liver tests were registered, whereas in the II group, an increase in the activity of ALT and AST in 2.4 (p<0.05) and 2.9 times (p<0.01) was revealed, as well as an increase in the levels of γ‑glutamyltranspeptidase (p<0.01) and alkaline phosphatase (p<0.01), and increase in the fraction of direct bilirubin. Patients of the II group were less satisfied with the treatment: the indicators of the visual analog scale were 4.97±068, compared to the I group (8.43±1.21, p<0.05).
Conclusions. Against the background of AHT (PPI in a standard dose, amoxicillin, clarithromycin, colloidal bismuth subcitrate) for 14 days, signs of drug‑induced liver damage were detected, which persisted for 4 weeks after the end of therapy. Hepatocomplex Lesil® is an effective means to prevent drug damage to the liver. This is confirmed by the absence of signs of cytolytic and cholestatic syndromes in the group of patients who received Lesil® 2 capsules per day for 6 weeks in addition to the AHT. Hepatocomplex Lesil® demonstrated safety and good tolerance by patients who were satisfied with AHT in combination with Lesil®.
Clinical cases of toxic hepatitis: aspects of differential diagnosis with viral hepatitis
Authors: Kopcha V. S. , Koshak Y. F.
Published: November 2023

In modern conditions of environmental problems, practicing doctors increasingly have to provide assistance to patients with hepatitis, the cause of which is not only known viral agents, but also chemical poisons. General information about toxic, primarily drug‑induced, and viral hepatitis is given. The main hepatotoxic drugs are listed. Their classification, mechanism of action, clinical symptoms, biochemical and morphological changes in various toxic liver lesions are highlighted. Information on drugs with high hepatic extraction, for which there is a high risk of overdose, is highlighted. For patients from risk groups, it is advisable to at least halve the dose of such drugs in accordance with the decrease in hepatic blood flow. Drugs with low hepatic extraction have a minimal risk of overdose, although metabolic insufficiency with long‑term administration of such drugs may cause their accumulation. Finally, drugs that are excreted by the kidneys are practically devoid of the risk of hepatotoxicity. Other professional and household toxic substances that have a direct hepatotoxic effect are discussed (carbon tetrachloride, dichlorodiphenyltrichloromethylmethane, yellow phosphorus, amanito‑ and phallotoxins of the pale toadstool, various pesticides, etc.).
Clinical cases of own clinical observations of various toxic hepatitises are included. The general characteristics of viral hepatitis are given, primarily with an emphasis on their differential diagnosis with hepatotoxic lesions. The main signs of viral and toxic hepatitis are grouped in the table. For a successful differential diagnosis of toxic and viral hepatitis, it is necessary to apply a modern complex of anamnestic, clinical, biochemical, virological, instrumental and morphological examination methods as fully as possible.
Insignificancia y derecho penal económico
Authors: Bustos Rubio Miguel
Published: November 2023

El criterio de la insignificancia en Derecho penal tiene por finalidad limitar la punición de ciertos comportamientos de mínima lesividad o bagatela, que formalmente encajan en un tipo penal y que además afectan, si bien de forma mínima, a un bien jurídico. En el sector del Derecho penal económico es posible encontrar actualmente tipos penales cuyo alcance no ha sido correctamente delimitado por el legislador, y que permiten acoger intramuros de su tipicidad comportamientos de mínima lesividad. En este trabajo se parte de una conceptualización del criterio de la insignificancia, previa delimitación con otros conceptos próximos como el de adecuación social o el de riesgo permitido, realizándose una exégesis sobre su naturaleza y fundamento en un Derecho penal de máximos como el que actualmente impera en nuestras sociedades, y se termina por valorar la operatividad de dicho criterio en el marco de la delincuencia económica, a través de tres ejemplos seleccionados en el Código Penal.
¿Violaciones por engaño?
Authors: Castellví Monserrat Carlos
Published: November 2023

¿Pueden cometerse violaciones por engaño? La respuesta depende de qué signifique la palabra «consentimiento» del art. 178.1 CP. Este trabajo empieza poniendo de relieve que dicha palabra tiene, al menos, dos significados: uno débil (aceptación) y otro fuerte (aceptación libre y consciente). Tras exponer las consecuencias de interpretar de un modo u otro el «consentimiento» del art. 178.1 CP, se concluye que dicha palabra significa, simplemente, «aceptación». De esta forma, se niega la posibilidad de castigar como violaciones las relaciones sexuales que han sido aceptadas debido a un engaño (por ejemplo, dando a entender que una persona es soltera, rica, etc.). Sin embargo, más adelante se muestra que los engaños no solo pueden emplearse para lograr que otro acepte una relación sexual, sino también para ocultar la realización de un acto sexual que no se ha aceptado en absoluto. Esto sucede cuando se oculta alguno de los elementos que definen un acto sexual: el contacto corporal que implica o su naturaleza sexual. En estos casos, el sujeto engañado consiente un acto sexual (o médico) distinto al realizado. Y, por ello, dicho engaño puede dar lugar a una violación.
Paul Ricoeur's Hermeneutic Analysis on User Interface Design for Augmented Reality Baleganjur Applications
Authors: I Komang Try Adi Stanaya  , I Made Gede Arimbawa
Published: November 2023

Augmented reality technology or more popularly known as AR is a technology that implements interactive multimedia concepts. Augmented reality technology is a technology that combines the virtual world with the real world in real-time, through electronic devices such as cameras, sensors and software, augmented reality is able to display virtual objects in both 2D and 3D form in the real world. In this study, it focuses on analyzing the appearance of the interface design or the main menu application user interface by implementing augmented reality technology, with the name of the application, Augmented Reality Baleganjur. The user interface display on the main menu of the Baleganjur Augmented Reality application has design elements that can be translated with different meanings and understandings, depending on the user's point of view. This is the basis of this research, where the appearance of the user interface design on the main menu of the Baleganjur Augmented Reality application has design elements that can lead to different interpretations of meaning and understanding. The purpose of this study is of course to reveal the meaning and understanding of the design elements in the user interface design display of the Baleganjur Augmented Reality application, by conducting an in-depth analysis using Paul Ricoeur's Hermeneutics. As for the results of this study, it can be concluded that researchers as hermeneutics have an important role in interpreting and offering solutions, which can later be used as a reference for repairing or perfecting design elements in the application user interface, so that these design elements can convey meaning and understanding in a comprehensive and detailed manner to users.
Gong Rénténg Transformation From Sacral to Profan
Authors: Suhendi Afryanto  , Arthur Supardan Nalan  , Gustiyan Rachmadi
Published: November 2023

One type of gamelan art that is developing in West Java is Gong Rénténg which used to be often used in sacred ceremonial activities. The sacredness built into the art is inseparable from the belief system adopted by the community as its supporting community. Gong Rénténg's whereabouts then and now are experiencing dynamics of change which are quite important to study, especially his journey which was stopped for various reasons. Stagnant regeneration factors, changes in people's perspectives due to changes in belief systems, as well as the influx of imported arts that continue to intrude on traditional art life, are some of the main reasons this art has experienced ups and downs in its life. The research carried out has the style of cultural research involving key informants as triggers to explore the depth of the material. There are three models of cultural research as approaches taken by researchers, including; Life Story models, Grounded Theory, and Personal Narrative. While the research method used still uses qualitative research by taking locations in two different areas, namely: (1) Ciwaru Village, Cimalaka District, Sumedang Regency, and (2) Kedungsana Village, Plumbon District, Cirebon Regency. In Ciwaru village, the object of research is the art of Gong Rénténg Pusaka Langgeng, while in the village of Kedungsana it is the art of Gong Rénténg Ki Muntili. The results of the research conducted obtained the following information: (1) The Gong Rénténg Pusaka Langgeng art still adheres to adat in a standard way even though the next generation continues to decrease, and (2) The Gong Rénténg Ki Muntili art does two ways to keep it alive, namely ritual ceremonies as part of ancestral traditions are carried out as well as the process of inheritance with new interpretations.
The Role of State Financial Regulation in Solving Key Problems of Russian Regions on the Example of the Far Eastern Federal District
Authors:   Plekhanov Russian University of Economics, Moscow, Russian Federation, Kosov M. E. ,   Financial University under the Government of the Russian Federation Moscow, Russian Federation, Golubtsova E. V. ,   Plekhanov Russian University of Economics, Moscow, Russian Federation, Novikova E. S. ,   Plekhanov Russian University of Economics, Moscow, Russian Federation
Published: November 2023

The relevance of this research is defined by the importance of the Far Eastern Federal District in the context of reorientation of Russia’s logistics and infrastructure from West to East. The aim of the paper is to test the hypothesis about the positive impact of the used measures of state financial regulation on the development of the Far Eastern Federal District in order to solve its key problems. The authors faced the task to analyze and develop essential measures of state financial regulation at the regional level. The scientific novelty of the study lies in the development of those measures taking into account the changing importance of the region in Russia’s trade turnover. The practical relevance consists in the possibility of using the results in the development of public financial policy in the region. In addition, the article considers key problems of the region, the solution of which will have a positive impact on the country’s economic growth and can be achieved through the government financial measures suggested by the authors. Such measures include increasing the capacity of the Far East sea ports, which means the simultaneous development of the Russian logistical infrastructure, primarily railway infrastructure, to organize uninterrupted delivery of goods to the ports of the region; changing the structure of the trade turnover with a shift towards the export of high-tech products; solving the demographic problems and increasing the scientific and technological potential of the Russian Far East. The results of this study can be used to analyze other Russian regions in order to increase the economic potential of the country as a whole.
Historical changes, characteristics, and current significance of the spatial structure of Eurasia
Authors: Qingsong Wan , Shaolei Feng
Published: November 2023

This article examines the historical changes that took place in the Eurasian space during the preimperial, imperial and post-imperial periods, and analyzes its main characteristics in these three historical stages. On this basis, the historical experience and lessons learned are summarized, and it is emphasized that the future development of the Eurasian space requires a balance between the trends of globalization and regionalization, universality and specificity, localization and openness to the outside world.
The current wave of populism as a factor in the identity crisis in Europe
Authors: Xiaochen Shen
Published: November 2023

The wave of development since approximately 2012 was the manifestation of contemporary identity crisis in Europe. The low efficiency of EU crisis management had led the sense of insecurity which has already pervaded among communities combined with the sense of distrust toward political system impact the existing systematic identity. The populist wave in the past decade was the very consequence of this identity crisis.
Humour and Knowledge in Katherine Mansfield’s
Authors:   Department of English, Alexandru Ioan Cuza University of Iaşi, Romania, Nastase Florina
Published: November 2023

The present study intends to look at the ways in which humour enacts modes of knowledge and self-expression in Katherine Mansfield’s short story “The Daughters of the Late Colonel” (1921). The story revolves around two spinsterly sisters who have spent most of their lives tending to their tyrannical father and now find themselves at a loss when they are finally free of him. The narrative is both sympathetic and merciless towards the sisters’ fumbling attempts at independence, but the women are often in on the joke; humour is both a “black dressing-gown” which envelops the sisters and renders them objects of ridicule, but it is also a way out, offering a subversive counterpoint to the voice of the Father, as the sisters imagine the patriarch in very comical and undignified positions, while perceiving themselves as outsiders, “creeping off…like black cats”. Though the short story has often been read in terms of hopelessness and despair by Rhoda B. Nathan and Gerri Kimber, this paper wishes to show how humour modulates and moderates this hopelessness, allowing for the two single women to assert their personality within the stifling society of their time. The ridiculous, in this case, does not need to be a death sentence, but rather a form of knowledge and resistance: the spinsters are aware of the absurdity of their condition and the futility of their place in the modern world and choose comedy over tragedy.
Humour as Survival Strategy in Walter Scott’s Waverley,
Authors:   University of Bucharest, Romania., Vijea Cristian
Published: November 2023

Humour will be shown to be present in a selection of novels by Walter Scott, as a strategy to temper hot spirits on the brink of violence and pre-empt conflict in the fictional societies. Despite the contagious effect spreading to the reader himself, this type of humour relies on paralogical hints, language inadequacy or language gaps, which the fictional audience as well as the reader has to fill in. In the process of solving the linguistic inaccuracies, the audience (both fictional and the reader) is forced to notice the deliberate violation of communication and look for meaning elsewhere. The distance between expected and discovered meaning is so great that a bout of laughter is the result, and fictional tensions are depleted of power. It is my claim that the humorous effect constantly brings the intuitive paralogic collapse of a logic which previously fostered conflict by coagulating opposing factions around powerful feelings and pathos.
“Laughing in the Face of Patriarchy”:
Authors:   Department of Education Sciences in Early Childhood, Democritus University of Thrace, Greece, Papailia Artemis
Published: November 2023

Comics for children have a unique ability to entertain and educate young readers. Often dismissed as comical or unserious, comics are actually an important form of literature that can have a profound impact on children’s beliefs and values. This article will examine various approaches to feminist humor in the context of cultural studies in Mafalda, a popular Argentine comic strip that ran from 1964 to 1973, created by cartoonist Quino. The comic features a precocious and socially aware six-year-old girl named Mafalda, who frequently comments on politics, philosophy, and social issues, criticizing societal norms and structures. She constantly grapples with and questions the societal, political, and moral landscapes of her time, making astute observations that prompt readers to reflect on the complex world she is navigating. Beyond the humor and light-hearted exchanges, Mafalda emerges as a significant cultural text. It seamlessly intertwines entertainment with critical reflection, offering its audience not just a moment of leisurely reading but also compelling them to reckon with the profound questions and critiques articulated by its young protagonist. The use of humor in Mafalda not only serves as a form of critique but also empowers young girls and challenges the dominant gender narratives, because the comic employs gendered humor as a means of challenging traditional gender roles and stereotypes. This article explores the role of humor in Mafalda, specifically in relation to gender and how it challenges gender norms and expectations, ultimately offering a new perspective on gender and power dynamics in comics and beyond.
Managers As Decision Makers
Authors: Fitria Tegar
Published: November 2023

1.Pengambilan Keputusana.Keputusan-Membuat pilihan dari dua alternatif atau lebih.b.Proses Pengambilan Keputusan-Mengidentifikasi suatu masalah dan kriteria pengambilan keputusan serta pengalokasiannya bobot sesuai kriteria.-Mengembangkan, menganalisis, dan memilih alternatif yang bisa menyelesaikan masalahnya.-Menerapkan alternatif yang dipilih.-Mengevaluasi efektivitas keputusan.
The Thought Of Economy by Abu Ubaid and Abu Yusuf
Authors: ANNISA
Published: November 2023

catatan terkait pemikiran ekonomi Abu Ubaid dan Abu Yusuf dalam karyanya yaitu kitab Al-amwal dan kitab Al-kharaj
Individual decision making
Authors: Yusnia
Published: November 2023

Sebuah proses sadar membuat pilihan antara satu atau lebih alternatif dengan tujuan bergerak menuju beberapa keadaan yang diinginkan.
Pemikiran Ekonomi Pada Masa Rasulullah SAW
Authors: Wulan Sri
Published: November 2023

Makalah ini bertujuan untuk memberitahukan kepada teman-teman terkait sejarah pemikiran ekonomi islam
Mutakhara Fihi Ramadhani
Authors: Ramadhani Mutakhara fihi
Published: November 2023

Secara umum, ekonomi adalah perilaku manusia yang berhubungan dengan seperti apa proses dan cara memperoleh dan menggunakan produksi, distribusi, dan konsumsi. Ekonomi berkaitan dengan perilaku manusia yang didasarkan pada landasan serta prinsip-prinsip yang menjadi dasar acuan. Ilmu ekonomi Islam sebagai sebuah studi ilmu pengetahuan modern yang baru muncul pada tahun 1970-an, tapi pemikiran tentang ekonomi Islam telah muncul sejak Islam itu diturunkan melalui Nabi Muhammad SAW. Rujukan atau landasan utama pemikiran ekonomi Islam adalah Al Qur’an dan hadits. Pemikiran ekonomi Islam muncul bersamaan dengan diturunkannya Al Qur’an dan masa kehidupan Rasulullah pada akhir abad 6 M hingga awal abad 7 M.
Resume eksya ke 5
Authors: Indriyani Nolis Putri
Published: November 2023

Rangkuman ekonomi syariah pertemuan 6
Pemikiran Ekonomi Pada Masa Nabi Muhammad SAW
Authors: MA'RIFAH AINUN
Published: November 2023

Makalah ini dibuat bertujuan untuk memberitahukan kepada teman-teman terkait sejarah pemikiran ekonomi islam
Everything you wanted to know about the mathematics of dimensionality reduction and visualization but were afraid to ask: Teaching resources and activities
Authors: banerjee soumya
Published: November 2023

This work presents some teaching resources and activities to understand the mathematics of machine learning, unsupervised learning and visualization.
art.ANALISIS+COMPARATIVO+DE+LAS+CARACTERÍSTICAS+SOCIODEMOGRÁFICAS+DE+LAS+MUJERES+MIGRANTES+Y+COLOMBIANAS+CON+SÍFILIS+GESTACIONAL+NOTIFICADAS+EN+EL+VALLE+DEL+CAUCA+DURANTE+EL+2019-2021 (1)
Authors: Beltrán-Barrera Lilian
Published: November 2023

Esta investigación tiene como propósito analizar las características sociodemográficas de las mujeresmigrantes venezolanas y colombianas diagnosticadas con sífilis gestacional dando lugar a la producciónescrita de un artículo científico para aportar y fortalecer la investigación científica lo que permitirá latoma de decisiones en salud pública para hacer ajustes en planes y políticas a nivel nacional. Objetivo:Describir las características sociodemográficas de las mujeres migrantes y colombianas con sífilisgestacional notificadas en el valle del cauca durante el 2019-2021. Metodología: Tipo y diseño deestudio: Se desarrollará un tipo de estudio observacional, descriptivo de corte transversal. Este tipo deestudio mide a la vez la prevalencia de la exposición y del efecto, en una muestra poblacional, es decir,permite estimar la magnitud y distribución de una enfermedad en un momento dado. Los estudiostransversales, son una medición de variables independientes y dependientes que se realiza en el mismomomento (una sola medición). Este estudio se desarrolló en el Departamento del Valle del Cauca,teniéndose en cuenta los 41 municipios que hacen parte de este. Población notificada por SIVIGILAficha de notificación 740 que cumpla los criterios de definición operativa para cada caso. Paraseleccionar la población a estudiar se solicitó la base de datos obtenida de la vigilancia rutinaria delevento que realiza una entidad administradora de planes de beneficios en salud (EAPB) en eldepartamento del Valle del Cauca. Resultados: En el año 2019 se encontraron notificadas 223 mujerescolombianas, para el año 2020 se encontraron 178 mujeres de las cuales 2 (1.12%) son mujeresmigrantes venezolanas, 1 (0.56%) es migrante panameña y 175 (98.3%) son mujeres colombianas. Parael año 2021 se encontraron notificadas 256 mujeres colombianas. Para el año 2019 y 2021, losmunicipios con mayor prevalencia de sífilis gestacional fueron Cali y Buenaventura representado 2casos por 1000 nacidos vivos. La sífilis gestacional durante los años 2019, 2020, 2021 se presentó en elestrato bajo según la razón de prevalencia, sin embargo, la asociación entre esta variable no esestadísticamente significativa (IC 0,836-1,361). Conclusiones: los hallazgos de esta investigaciónsubrayan la necesidad de abordar las barreras de acceso a la atención médica, mejorar la educación sobresalud sexual y reproductiva, fortalecer el diagnóstico temprano y garantizar el tratamiento adecuado.Además, se destaca la importancia de abordar cuestiones culturales, como el machismo, y su impactoen la prevención y tratamiento de las ETS. Estos hallazgos proporcionan información valiosa para eldesarrollo de políticas de salud pública y estrategias de prevención de la sífilis gestacional en lapoblación estudiada.
MANAGEMENT CONTROL SYSTEM: RESPONSIBILITY CENTERS
Authors: Rizdkia Mutiara
Published: November 2023

Catatan terkait dengan subjek Sistem Pengendalian Manajemen (Management Control System) mengenai Responsibility Centers: Revenue and Expense Centers
Resume spm ke 1
Authors: Indriyani Nolis Putri
Published: November 2023

Rangkuman sistem pengendalian manajemen pertemuan 2
Revolutionizing Drug Discovery: Quantum-Based Machine Learning Simulation for Tomorrow's Medicine
Authors: Ayuba Adegoke , Tera Terry , Kelvin Lawrence
Published: November 2023

The pharmaceutical industry has reached a pivotal moment, where the integration of quantum computing and machine learning stands to redefine the drug discovery process. This article explores the implications of Quantum-Based Machine Learning Simulation (QMLS) and its potential to shape the future of medicine. We delve into the convergence of quantum computing, artificial intelligence, and drug development, highlighting the promising breakthroughs and challenges ahead.
DETERMINANTES SOCIALES DE COVID-19 EN NIÑOS Y ADOLESCENTES EN COLOMBIA: REVISIÓN BIBLIOMÉTRICA Y EXPLORATORIA
Authors: Espinosa Jobany Castro , Aguilar Pamela Mina , Viveros Alvarez Akemi D , P Angely , Cajas Carlos Humberto Martinez
Published: November 2023

El COVID-19 hace parte de la familia de los coronavirus (CoV) que son virus que causan infecciones respiratorias agudas, es decir gripa, que pueden llegar a ser de leves a graves. Sin embargo, el nuevo Coronavirus (COVID-19) ha sido catalogado por la Organización Mundial de la Salud como una emergencia en salud pública de importancia internacional (ESPII), debido a diferentes artículos e investigaciones se mostraron como el COVID-19 afectó y aumentó la morbilidad de diferentes poblaciones. Objetivos: Identificar la producción bibliométrica sobre determinantes sociales relacionados con la infección de COVID-19 en población colombiana entre 6 y 17 años. Métodos: Este estudio se diseña sobre la estructura de la síntesis de literatura denominada Revisión exploratoria o Scoping review. En donde la población de estudio fueron artículos cuya población en estudio sean niños y adolescentes hasta los 18 años. Como criterios inclusión y exclusión; Se incluyen artículos en inglés y español sobre determinantes sociales en niños y adolescentes en Colombia; Se excluyen artículos sin disponibilidad de texto completo. Resultados: Uno de los estudios mostró más de 1684 de casos de covid-19 los cuales fueron incluidos en el estudio. En donde hubo 217 (12,9%; ic 95% 11,3 a 14,5) casos graves, de los cuales el 32,6% (ic 95% 26,4 a 38,8) fallecidos. En la regresión logística multinivel, la edad, el sexo (mujer), el tipo de caso (diferente al caso importado), el número de casos graves registrados el día anterior y la pobreza multidimensional se asociaron a los casos graves (mediana or: 1.72, ic 95% 1.56 a 1.87). Se mostró un alto índice de casos de COVID-19 en Colombia llegando a 750. 516 casos y contando junto con los departamentos con mayor incidencia acumulada (IA) de casos positivos por COVID-19 fueron Bogotá 6,084%, Quindío 4,257%, Antioquía 3,917%, San Andrés 3,487%, Caquetá 3,654% y Atlántico 3,452%; aquellos con menor IA fueron Arauca 1,555%, Magdalena 1,493%, Guajira 1,466%, Cauca 1,254% y Vichada 1,018%. Conclusión: Por medio de las diferentes literaturas recopiladas se concluyó que los determinantes sociales influyen sobre el proceso de salud-enfermedad de los niños y adolescentes con factores socioeconómicos desfavorables, muchos de los artículos evidenciaron las desigualdades socioeconómicas en los estratos 1,2,3 ya que se vio una seroprevalencia mayor en estos estratos. ya que el COVID-19 tuvo gran impacto en el área socioeconómico aumentando la pobreza ,también tuvo impacto en la salud mental, en la alimentación y todos estos factores se vieron ligados al aumento en la morbilidad y letalidad por esta enfermedad, encontrándose que las malas condiciones de vida, una depresión crónica, obesidad o desnutrición están significativamente relacionadas con tener una prueba de anticuerpo sars-cov-2 positiva y altos índices de gravedad.
Advancing Regional Flood Mapping in a Changing Climate: A HAND-Based Approach for New Jersey with Innovations in Catchment Analysis
Authors: Bazzett David , Wang Ruo-Qian , Marxen Lucas
Published: November 2023

Regional flood mapping poses computational and spatial heterogeneity challenges, exacerbated by climate change-induced uncertainties. This study focuses on creating a state-wide flood mapping solution with enhanced accuracy and computational speed to support regional flooding hazard analysis and the assessment of climate change, using New Jersey as a case study. The Height Above Nearest Drainage (HAND) framework was employed for large-scale flood mapping. The model was validated against high water marks (HWMs) collected after Hurricane Irene. Based on the National Water Model (NWM), synthetic rating curves in HAND were calibrated by tuning Manning’s roughness, aligning the predicted and observed flood depths. The roughness values were generalized across the state from the validated water basins to the ungauged ones, using a multivariate regression with the hydrologic and geographic information. To map the future climate-change-induced flooding, a correlation between NOAA historical precipitation totals and NWM flow data from 2010-2020 was established to link precipitation and runoff. This study also invented a novel method for correcting catchment discontinuities, inherent in the HAND model, based on a computer vision scheme, the Sobel filter. The modeling results show that average and worst-case storm events have the potential to increase 10-50% in the state, where mountain areas and major river banks would be exposed to this impact more significantly.
Paleogeography and 3D variability of a dynamically uplifted shelf: observations from seismic stratigraphy of the Paleocene East Shetland Platform
Authors: Valore Lucas , Sømme Tor , Patruno Stefano , Robin Cécile , Guillocheau François , Eide Christian
Published: November 2023

In the Paleocene North Sea, pulses in turbidite fan deposition and shelfal progradation have been correlated to episodes of regional uplift caused by a precursor of the Icelandic Plume. However, in the East Shetland Platform, the specific impacts of dynamic uplift on the regional paleogeographic evolution are less understood. Using new, high resolution 3D seismic data from an underexplored proximal area, we investigate the paleogeography of the East Shetland Platform in terms of the extent and timing of erosion vs deposition, focusing on how these can be used to reconstruct changes in relative sea-level along-strike. Using a combination of well data, clinoform-based seismic stratigraphy and seismic attribute analysis of >60 000 km² of 3D data, we have devised paleogeographic maps of multiple Paleocene to Early Eocene units, with high temporal resolution for the Late Paleocene – Early Eocene Moray Group. This includes six unconformity-bounded units marked by prograding clinoforms of the Dornoch Formation, which are covered by backstepping sequences of the Beauly Member (Balder Formation). Temporal and spatial changes in the distribution of downdip depocenters and updip unconformities indicate strong lateral variability in patterns of shelf accommodation/erosion and local sediment supply. This results from a complex interplay between laterally-uneven RSL fall, inherited topography, time-varied sediment entry point distribution and along-shore sediment transport regimes. Unconformities and paleogeographic maps suggest a first-order control on erosion and sediment distribution promoted by the transiently and differentially uplifted topography of Shetland, which is characterized by an anomalous erosive history in the Bressay High in the center of our study area, where the Lower Dornoch Formation has been eroded and marked fluvial incision is observed. Ultimately, results indicate shorter-wavelength and shorter-period variations in uplift than what is typically assumed for dynamic topography, perhaps as a result of additional modulation by lithospheric structures or influence of previous rift-related faults.
Developing an implementation model for the inclusion of children with developmental disabilities in mainstream primary schools in Ethiopia
Authors: Genovesi Elisa , Ayele Moges , Ahmed Ikram , Belay Winini , Burningham Olivia , Chen Amanda , Girma Fikirte , Lakew Liya Tesfaye , Hanlon Charlotte , Hoekstra Rosa
Published: November 2023

Children with developmental disabilities (DD) in Addis Ababa, Ethiopia, are often excluded from education. Progression towards inclusion in mainstream schools is encouraged by policies, but these have infrequenty been translated into implementation on the ground. Through 39 semi-structured interviews, we aimed to build an implementation model to promote the inclusion of children with DD in Addis Ababa, based on stakeholders’ perspectives and recommendations. Stakeholders interviewed included caregivers of children with DD, school teachers and principals/managers, non-governmental organization representatives, government officials, clinicians and academics/consultants. Themes were developed deductively using template analysis and based on Implementation domains of the Context and Implementation of Complex Interventions framework Pfadenhauer et al., 2017. From an implementation Theory perspective, the most endorsed conceptualisation of inclusion was enrolment of children with DD with moderate to high support needs in special education units in mainstream schools; mainstream classes were considered an appropriate education approach for children with DD with milder needs. When discussing the implementation Process, stakeholders noted that commitment of all stakeholders and systematic changes are needed for sustainable progress. Recommended Implementation Strategies to address expectations and challenges of key implementation Agents (children, caregivers, and teachers) were raising awareness in the community, training and supporting teachers, and supporting children’s development through healthcare and family interventions. The implementation model developed aims to offer children with DD opportunities to progress academically in special and inclusive classes, through systematic change, commitment of all stakeholders and specific implementation strategies. The latter should be targeted at supporting teachers, children and caregivers and raising awareness in the community.
Biased or noisy? Motivational biases and decision noise across development
Authors: Scholz Vanessa , Waltmann Maria , Herzog Nadine , Horstmann Annette , Deserno Lorenz
Published: November 2023

Learning and decision-making undergo substantial developmental changes. In adolescents, both specific developmental changes of choice behavior, such as in motivational choice bias, and generally higher levels of decision noise have been observed. However, it remains unknown whether these two observations are independent or related. A not yet investigated possibility is that the specific development of motivational choice bias might depend on decision noise. We examined 93 participants (12 – 42 years) with a motivational Go/NoGo task, assessing ‘Pavlovian’ choice bias and disentangling it from instrumental learning biases. Participants performed two more reinforcement learning (RL) tasks to test cross-task generalization of computational parameters such as decision noise. Using mixed-effects models, we find an age-related increase in Pavlovian choice bias while instrumental learning bias did not change with age. Implementing a novel adaptation of a computational RL model with outcome-specific noise parameters (‘feedback sensitivity’) showed increases in Pavlovian choice bias and sensitivity for positive feedback with age. Beyond these within-task developmental age effects, noise levels are, firstly, strongly correlated across RL tasks and, secondly, mediate age dependent performance gain and more sophisticated RL processes, i.e., model-based control over choices. Taken together, our findings provide novel insights into the computational processes underlying developmental changes in decision-making: namely a vital role of seemingly unspecific changes in noise in the specific development of more complex learning and choice components. Studying the neurocomputational mechanisms of how varying levels of noise impact distinct aspects of learning and decision processes may also be key to better understand the developmental onset of psychiatric diseases.
An Age–Period–Cohort Model in a Dirichlet Framework: A Coherent Causes of Death Estimation
Authors: Graziani Rebecca , NIGRI ANDREA
Published: November 2023

Though pivotal in longevity studies, multi-outcome modelling is largely neglected in the associated statistical literature. Here, we focus on the case of compositional data, especially relevant in longevity analysis, where overall mortality can be described as the composition of several causes of death. We propose an age–period–cohort model within the Dirichlet framework with a specific interest in its use for modelling longevity with multiple causes of death. We introduce a flexible approach to incorporating the Dirichlet distribution into the age–period– cohort framework. Then, using US cause-specific mortality data, we provide a comprehensive discussion and comparison of alternative modelling approaches.
Perceptions of Students Toward Physics Learning Strategies at the Secondary Level
Authors: Dawadi Sandeep
Published: November 2023

The study aimed to find out the perception of students towards physics learning strategies and to analyze perceptions of the student’s learning strategies. The research design is quantitative in nature and follow survey design with random sampling methods to take the perceptions of 500 students for the sample size was selected 75 students from five government school towards physics learning strategies. Data was collected by using paper based closed ended, which utilized a Likert scale format. Descriptive statistics such as frequency, percentage, mean and standard deviation were used for the analysis of data. The study revealed that students generally exhibited a positive attitude towards learning physics and showed a preference for social interaction, group study, ICT based learning, logic resonance, collaborative learning, note taking, and note making, problem solving, laboratory method and feedback from teachers. While the use of lecture method and rote learning strategies, students gave a negative response. The study emphasized the importance of considering students' opinions and preferences when designing and implementing effective learning strategies. It suggested that teachers and educators prioritize the use of collaborative learning, laboratory methods, feedback and problem solving strategies in physics classes. A physics lab is required to effectively understand the material for students towards visualizing concepts in physics were positive from the statements that visualizing concepts helps students remember and understand physics easily and quickly. This study also highlighted the need for further research to explore the integration of these effective learning strategies into physics instruction in order to enhance student learning outcomes.
Menstruation Hygiene Practices Among Girl Students in Kathmandu Valley
Authors: Upadhya Shanta , Adhikari Anup
Published: November 2023

The study, titled "Menstruation hygiene practices among higher-level girls students," explores the natural process of menstruation in the female reproductive system occurring monthly. Governed by hormonal changes, menstruation is a pivotal facet of the menstrual cycle, and fertility and associated with physical and emotional symptoms like cramps, mood swings, and fatigue. Proper menstrual hygiene practices are vital for women's health during this period. Inadequate water, sanitation, hygiene facilities, limited education, and deficient menstrual hygiene management make girls perceive menstruation as embarrassing and uncomfortable. In Nepal, many teenage girls lack education about menstruation, adversely affecting their health. The study aims to assess menstruation hygiene practices among higher-level female students before and during menstruation. Using quantitative and descriptive methods, the research selected 250 students through simple random sampling from 650 enrolled on two constituent campuses. These campuses were chosen via convenience sampling from 22 within the Kathmandu Valley. Ethical considerations were followed, ensuring confidentiality and obtaining oral consent from participants. The findings underline the significance of comprehensive menstrual health education and the sway of cultural beliefs on menstruation experiences. Encouraging open discussions, dispelling myths, ensuring access to accurate information, and cultivating supportive environments are essential for enhancing menstrual health and overall well-being.
Use of Mobile/Smart Phones and Students' Mathematics Learning: A Case of Basic Schools in Nepal
Authors: Ghimire Shree Prasad
Published: November 2023

This study is mainly focused on the students' mobile using habit and its impact on teaching and learning mathematics. The study method was survey with 119 students of public and institutional schools in the Chandragiri Municipality of Kathmandu. Questionnaire is use for identifying the access and use of mobile for learning and achievement test for measuring the students' achievement as tools for the study. The study found that 89.9% students had access of smartphones at their home including personal as well as their own. The utilization of mobile smart phone is the genuine concern for the proper utilization for learning. The results indicated that, the use of mobile in planned learning for a specified time enhanced the mathematics performance of students. Adversely, those students who engaged on mobile/smart phones higher in hours and not using mobile for learning purpose decreased their achievement in mathematics. Gender difference observed in using mobile that boys used mobile more hours than the girls. Further, entertainment type of application/programme such as music videos, song were the favorite program for girls whereas games related programme was the favorite programme for boys in the use of mobile/smart phones. Two hours/day was found the standard time to use mobile/smart phones for better performance in mathematics.
Mathematics Teachers' Perception Towards Educational Technology Integration: Mahendra Ratna Campus Tahachal
Authors: Acharya Umesh
Published: November 2023

Integrating educational technology in mathematics education has emerged as a transformative force revolutionizing traditional teaching/ learning(T/L) practices. Understanding mathematics teachers' perceptions regarding technology integration is vital in fostering successful adoption and implementation in their T/L practice. Utilizing a structured questionnaire with Likert-scale items, the study gathered data on teachers' perceptions of technology's effectiveness and its impact on student learning outcomes. The findings revealed highly positive perceptions among mathematics teachers, with mean scores ranging from 3.73 to 4.33 and statistically significant p-values (p < 0.05). Moreover, the study found no significant differences in various perceptions based on gender, academic level, teaching experience, or level of teaching. The results emphasize the potential benefits of incorporating educational technology in mathematics education and provide valuable insights for stakeholders seeking to enhance mathematics learning experiences at Mahendra Ratna Campus and beyond.
Advertising – a Necessary “Elixir of Life” for Capitalism: On the Critique of the Political Economy of Advertising
Authors: Knoche Manfred
Published: November 2023

This contribution aims to lift the ideological veil of apologetics and pseudo-criticism on advertising with the help of a reality-based systematic analysis that contributes to a materialistic theory of advertising. The content-related and methodological basis of such a theory is a Critique of the Political Economy of Advertising oriented towards the critique of capitalism and academic knowledge originally presented by Karl Marx and current societal analyses based on it. In this context, the academic objective is to consider the economic, political, and societal functions of (media) advertising. In doing so, the elementary economic and ideological functions of advertising for the existence and further development of the market economy and capitalist economic and societal systems become recognisable. Advertising then no longer appears as a necessary evil but as a necessary "elixir of life” for the media industry, the economy, and capitalism as a whole. Based on the applied critical political-economic analysis, it becomes clear that on the level of capitalism as an economic and societal system, advertising thus contributes economically and ideologically to the stabilisation of the systemic foundations of capitalist societies (the capital-labour relationship, the regime of accumulation; the economic, societal, and political [advertising] functions of the media). It is shown that a Critique of the Political Economy of Advertising – especially from the point of view of the necessarily growing importance of advertising for media production – also contributes to the development of a Critique of the Political Economy of the Media.
PENERAPAN DMAIC DAN FMEA UNTUK PENGENDALIAN KUALITAS PRODUK KEMASAN KERTAS PERUSAHAAN PERCETAKAN PT.XYZ
Authors: Wardana Aji Pramudya
Published: November 2023

Perkembangan zaman yang semakin maju berdampingan dengan perkembangan teknologi industri sehingga menjadi ketatnya kompetisi bisnis. Maka para perusahaan bersaing untuk menghasilkan produk yang memiliki kualitas tinggi .Rata-rata persentase cacat selama periode 2021 memiliki persentase cacat sebesar 3,42%. Dengan tinginya presentase cacat pada perusahaan yang mencapai 3,42% telah melewati ambang batas cacat yang telah ditetapkan oleh perusahaan. Perusahaan memberikan batas cacat sebesar 3% tetapi pada kenyataan di lapangan menunjukan persentase cacat yang sudah melewati batas. Ketidak sesuaian dari hasil cacat dengan standar yang ditetapkan perusahaan berdampak terhadap proses produksi. Diperlukan pengendalian kualitas produk yang bertujuan agar perusahaan menghasilkan produk sesuai dengan standar perusahaan. Pengendalian kualitas menggunakan metode DMAIC (Defect, Measure, Analyze, Improve, and Control. Dengan menjadikan Failure Mode and Effect Analisys  FMEA sebagai analisis terhadap produk cacat dan melakukan metode DMAIC (Defect, Measure, Analyze, Improve, and Control) untuk melakukan perbaikan pengendalian kualitas. Berhasil mengidentifikasi penyebab cacat yang terjadi pada saat produksi dan menemukan penyelesaian yang bisa dilakukan untuk menurunkan tingkat cacat produk. Berhasil melakukan penerapan pengendalian kualitas dengan metode DMAIC dan FMEA sehingga terjadi penurunan persentase cacat produk dari 3,42% menjadi 1,14%. Dengan penurunan yang terjadi sudah sesuai dengan target menurunkan cacat dibawah 3%.