bluuebunny/crossref_metadata_2025 huggingface dataset:
A Combined Experimental and Computational Study on the Palladium-Catalyzed Sequential [2+2+1] Spirocyclization/Arene C–H Activation of 4-Iodo-2-quinolones with Diphenylacetylene
Authors: Yamamoto Yoshihiko , Hirako Naohiro , Yasui Takeshi
Published: November 2020

The palladium-catalyzed reaction of 4-iodo-2-quinolones with diarylacetylenes in the presence of Ag2CO3 as a base in N,N-dimethylformamide (DMF) at 100 °C afforded unprecedented polyfused 2-quinolones via sequential [2+2+1] spirocyclization/arene C–H activation. A plausible mechanism is suggested based on control experiments and density functional theory (DFT) calculations.
O DIREITO E LITERATURA PELAS MARGENS: O NOVO BOOM LATINO-AMERICANO E A LITERATURA DOS SILENCIADOS
Authors: Karam Henriete , Espíndola Angela
Published: November 2020

Objetivo: O artigo tem por objetivo investigar a eventual singularidade que os estudosem Direito e Literatura apresentam no contexto da América Latina e, em especial, doBrasil.Metodologia: Emprega-se a perspectiva metodológica oferecida pela hermenêutica-filosófica para examinar os fatores que favoreceram o boom literário latino-americano e para compreender sua estética, através da análise dos elementos presentes no romance Incidente em Antares, de E. Verissimo.Resultados: O percurso investigativo realizado possibilitou relacionar a função que a literatura assumiu no período das ditaduras políticas que marcaram os países latino-americanos com o papel que o movimento direito e literatura vem desempenhando no contexto social e político dos países da América Latina, pós-processos de redemocratização.Contribuições: A possibilidade de se atribuir, aos estudos em Direito e Literatura, o estatuto de novo boom latino-americano configura-se na medida em que: (1) seu epicentro passa a ser a literatura produzida por vozes antes silenciadas, que começam a se fazer ouvir através da literatura marginal ou periférica; e (2) seus pesquisadores, que superam o senso comum acrítico, assumem um compromisso jurídico, social e político com aqueles que se encontram ou são colocados à margem.
DIREITO E ORDEM: DA RETÓRICA LITERÁRIA À RETÓRICA JURÍDICA
Authors: Malato Maria Luísa
Published: November 2020

Objetivo: A análise do binómio “lei e ordem” tem por intuito relacionar o processo de leitura dos textos literários ou dos textos cinematográficos, aplicando-os ao processo de leitura dos factos jurídico-políticos, com evidência da “ordem” dos factos na interpretação dos factos.Metodologia:Quatro meios de demonstração foram usados: os dedutivos, tendo por base os estudos retóricos, sobre a distorção operada pela ordem dos fatores; os indutivos, que aproximam a análise dos discursos jurídicos (que se querem próximos da objetividade) da análise dos discursos artísticos (assumidamente subjetivos); os analógicos, que pressupõem a constante presença da ficção nos raciocínios das ciências humanas; e os de autoridade, que remetem, sobretudo, para a importância da obra retórica de um jurista espanhol, Francisco Puy.Resultados: O ensaio identifica como fundamental a reflexão dos juristas sobre a importância da ordem no discurso, nomeadamente dos factos relatados no processo, atendendo aos seus inevitáveis efeitos de conformação e/ou manipulação.Contribuições: As duas principais contribuições desta pesquisa serão a valorização dos estudos retóricos em geral (e de juristas, como Francisco Puy, em particular), e a vantagem de uma educação humanística/ artística dos juristas, em geral, formados na crença dessa neutralidade retórica da interpretação dos factos.
POPULISMO & PRECONCEITO: CLARIFICANDO QUESTÕES IDEOLÓGICAS E JURÍDICAS DE UM VÍRUS POLÍTICO, EM DIÁLOGO COM UMBERTO ECO
Authors: Cunha Paulo Ferreira da
Published: November 2020

Objetivo: O objetivo do presente artigo é fazer uma arqueologia do sentido profundo do populismo e entidades a ele associadas, procurando identificar alguns traços mais ou menos perenes dessa realidade psicológica, social, e política, com importantes consequências jurídicas.Metodologia: Este trabalho foi desenvolvido por meios dedutivos, com base em aportações bibliográficas pós-disciplinares (no sentido de Gonçal Mayos e sua escola) oriunda essencialmente dos campos da Psicologia Social e da Sociologia, da História das Ideias Políticas, etc., visando de forma estruturada carrear os conhecimentos multiplamente centrados epistemicamente para a indagação. Seguiu-se explicitamente a contribuição do semiólogo italiano do maior renome internacional Umberto Eco.Resultados: Apesar de haver juristas que consideram tabu temas que possam ser mais polémicos politicamente, e talvez mais ainda social e civilizacionalmente, remetendo-se a uma “castidade metódica” tecnicista, quer a questão do preconceito quer a do fascismo são, não apenas desafios sócio-políticos inafastáveis nos tempos que correm, como colocam objetivamente questões às quais os juristas se não podem furtar. Questões de efetivação real de Direitos Humanos e direitos tout court, e questões da própria sobrevivência dos Estados democráticos de direito, ou seja, questões absolutamente constitucionais e das mais importantes. Concluiu-se, preliminarmente, que é fundamental discutir preconceito e fascismo.Contribuições: Neste artigo, em diálogo com Umberto Eco, um autor cujas teses estão agora internacionalmente a ser revisitadas, avançamos uma análise que parte da tese de que o fascismo é a apoteose dos preconceitos clássicos, antigos, tradicionais. E que obviamente ele não é apenas uma ideologia historicamente situada, ou somente um período localizado na história da Italiano do séc. XX. Se nos repugna dizer que ele é eterno, é certo que tem avatares que sempre retornam. Há um “eterno retorno” do fascismo, com vestes diferentes, mas com traços comuns. E seria estulto e suicida que as democracias, e os juristas democratas não vissem que esse é, aqui e agora, o grande perigo que ameaça o nosso comum modo de viver e progredir: o Estado Constitucional. Em cada um dos tópicos que retomam a perspetiva de Eco se avançam contribuições matizadoras ou aprofundamentos.
DEVILS: a tool for the visualization of large datasets with a high dynamic range
Authors: Guiet Romain , Burri Olivier , Chiaruttini Nicolas , Hagens Olivier , Seitz Arne
Published: November 2020

The number of grey values that can be displayed on monitors and be processed by the human eye is smaller than the dynamic range of image-based sensors. This makes the visualization of such data a challenge, especially with specimens where small dim structures are equally important as large bright ones, or whenever variations in intensity, such as non-homogeneous staining efficiencies or light depth penetration, becomes an issue.

While simple intensity display mappings are easily possible, these fail to provide a one-shot observation that can display objects of varying intensities. In order to facilitate the visualization-based analysis of large volumetric datasets, we developed an easy-to-use ImageJ plugin enabling the compressed display of features within several magnitudes of intensities. The Display Enhancement for Visual Inspection of Large Stacks plugin (DEVILS) homogenizes the intensities by using a combination of local and global pixel operations to allow for high and low intensities to be visible simultaneously to the human eye.

The plugin is based on a single, intuitively understandable parameter, features a preview mode, and uses parallelization to process multiple image planes. As output, the plugin is capable of producing a BigDataViewer-compatible dataset for fast visualization.

We demonstrate the utility of the plugin for large volumetric image data.
Applications of GIS and geospatial analyses in COVID-19 research: A systematic review
Authors: Ahasan Rakibul , Alam Md. Shaharier , Chakraborty Torit , Hossain Md. Mahbub
Published: November 2020

Background: Geographic information science (GIS) has established itself as a distinct domain and incredibly useful whenever the research is related to geography, space, and other spatio-temporal dimensions. However, the scientific landscape on the integration of GIS in COVID-related studies is largely unknown. In this systematic review, we assessed the current evidence on the implementation of GIS and other geospatial tools in the COVID-19 pandemic.

Methods: We systematically retrieved and reviewed 79 research articles that either directly used GIS or other geospatial tools as part of their analysis. We grouped the identified papers under six broader thematic groups based on the objectives and research questions of the study- environmental, socio-economic, and cultural, public health, spatial transmission, computer-aided modeling, and data mining.

Results: The interdisciplinary nature of how geographic and spatial analysis was used in COVID-19 research was notable among the reviewed papers. Although GIS has substantial potential in planning to slow down the spread, surveillance, contact tracing, and identify the trends and hotspots of breakdowns, it was not employed as much as it could have been. This review not only provided an overarching view on how GIS has been used in COVID-19 research so far but also concluded that this geospatial analysis and technologies could be used in future public health emergencies along with statistical and other socio-economic modeling techniques. Our systematic review also provides how both scientific communities and policymakers could leverage GIS to extract useful information to make an informed decision in the future.

Conclusions:  Despite the limited applications of GIS in identifying the nature and spatio-temporal pattern of this raging pandemic, there are opportunities to utilize these techniques in handling the pandemic. The use of spatial analysis and GIS could significantly improve how we understand the pandemic as well as address the underserviced demographic groups and communities.
Ripple effects of research capacity strengthening: a study of the effects of a project to support test facilities in three African countries towards Good Laboratory Practice certification
Authors: Begg Sara , Wright Alexandra , Small Graham , Abdoulaye Diabate , Kisinza William , Koudou Benjamin , Moore Sarah , Mosha Franklin , Edi Constant , Kirby Matthew , Kija Patrick , Malima Robert , Moore Jason , Bates Imelda
Published: November 2020

Background: Strengthening capacity for public health research is essential to the generation of high-quality, reliable scientific data. This study focuses on a research capacity strengthening project supporting seven test facilities in Africa conducting studies on mosquito vector control products towards Good Laboratory Practice (GLP) certification. It captures the primary effects of the project on each facility’s research capacity, the secondary effects at the individual and institutional level, and the ripple effects that extend beyond the research system. The relationships between effects at different levels are identified and compared to an existing framework for the evaluation of research capacity strengthening initiatives.

Methods: To capture the views of individuals engaged in the project at all levels within each facility, a maximum-variation purposive sampling strategy was used. This allowed triangulation between different data sources. Semi-structured interviews were conducted with individuals in three facilities and a combination of email and remote video-call interviews were conducted with individuals at two further facilities.

Results: We found that, despite a focus of the GLP certification project at the institutional level, the project had effects also at individual (including enhanced motivation, furtherment of careers) and national/international levels (including development of regional expertise). In addition, we detected ripple effects of the project which extended beyond the research system.

Conclusion: This study shows that research capacity strengthening interventions that are focussed on institutional level goals require actions also at individual and national/international levels. The effects of engagement at all three levels can be amplified by collaborative actions at the national/international level. These findings show that research capacity strengthening projects must develop plans that address and evaluate impact at all three levels. Capturing the ripple effects of investment in research capacity strengthening should also be planned for from the beginning of projects to support further engagement of all stakeholders.
ПРИМЕНЕНИЕ МЕТОДОВ МОДЕЛИРОВАНИЯ И ОПТИМИЗАЦИИ ИНФОРМАЦИОННЫХ СТРУКТУР ДЛЯ УПРАВЛЕНИЯ ТРАНСПОРТНЫМИ ПРЕДПРИЯТИЯМИ
Authors: Lvovich Yakov Yevseevich , Preobrazhenskiy Andrey Petrovich , Choporov Oleg Nikolaevich
Published: November 2020

В данной работе рассматривается подход, связанный с управлением в компаниях, связанных с перевозками, при помощи разных видов программного обеспечения. При решении данной задачи мы рассматривали возможности использования компьютерных технологий, методик моделирования и оптимизации.
МАТЕМАТИЧЕСКАЯ МОДЕЛЬ ПРОЦЕССА ДВИЖЕНИЯ АВТОМОБИЛЯ ПО ПОПЕРЕЧНОМУ УКЛОНУ
Authors: Tikhov-Tinnikov Dmitry Anatolyevich , Fedotov Alexander Ivanovich , Alekseev Alexey Vasilyevich
Published: November 2020

В статье представлено аналитическое исследование влияния технического состояния системы подрессоривания на параметры устойчивости автомобиля. Исследуется процесс движения по поперечному уклону при возмущенном состоянии подвески. В качестве оценочных параметров устойчивости движения предложено использовать величины бокового смещения, угла поворота и времени переходного процесса угловой скорости.Цель – Теоретическое обоснование метода диагностирования подвески по кинематическим параметрам автомобиля.Методы проведения работы: использованы методы математического моделирования и численные методы решения дифференциальных уравнений.Результаты: разработан математический аппарат для аналитического исследования процесса движения автомобиля при изменении параметров технического состояния амортизаторов.Область применения результатов: результаты могут быть использованы организациями и учреждениями, занимающихся разработкой методов диагностирования автотранспортных средств.
Una obra inédita de Diego López Bueno y Alonso Vázquez: el retablo de la capilla de la Concepción en el convento casa grande de San Francisco de Sevilla.
Authors: Amores Martínez Francisco
Published: November 2020

En el presente trabajo damos a conocer una nueva obra realizada por el escultor y arquitecto Diego López Bueno y el pintor Alonso Vázquez en 1597: el retablo para la capilla de la Concepción en el convento de San Francisco de Sevilla, propiedad del mercader Sebastián Pérez, y las circunstancias del pleito a que dio lugar su ejecución, en el cual intervinieron otros artistas de la época.
Los púlpitos para el canto de la epístola y del evangelio en las iglesias parroquiales de Jerez de la Frontera (siglos XVI-XVIII)
Authors: Pomar Rodil Pablo J.
Published: November 2020

La funcionalidad de los púlpitos gemelos o ambones, que, ubicados a la entrada del presbiterio, servían para el canto de la epístola y el evangelio durante las misas solemnes celebradas con asistencia de ministros sagrados, ha venido siendo relegada por los trabajos de historia del arte que de estos elementos se han ocupado. El presente artículo trata de clarificar su uso y deslindarlos funcionalmente del púlpito de la predicación. Para ello se analizan, como una suerte de muestreo local de un asunto general, los de las parroquias de una de las poblaciones de mayor vitalidad eclesiástica del antigua archidiócesis de Sevilla, la de Jerez de la Frontera.
Dos nuevas obras del pintor novohispano Antonio de Torres (1667-1731): el Santo Ecce Homo del portal del convento de la Encarnación de Granada y la Dormición de la Virgen del Seminario de Sacerdotes Operarios Diocesanos de Ciudad de México
Authors: Gila Medina Lázaro
Published: November 2020

Este trabajo tiene como fin dar a conocer dos nuevas pinturas de Antonio de Torres (1667-1731): una consagrada al desaparecido Santo Ecce Homo del Portal de Mercaderes de la Plaza Mayor –hoy Zócalo– de Ciudad de México, localizada en el convento de la Encarnación de Granada, y la segunda dedicada a la Dormición de la Virgen del Seminario de Sacerdotes Operarios Diocesanos en aquella gran metrópoli, firmadas y fechadas, respectivamente, en 1726 y 1713. Mas, como preámbulo, ofrecemos un resumen histórico-artístico de dicho convento y un apunte biográfico del artista.
“Para la memoria del pastor dadivoso”: un retrato del arzobispo Delgado y Venegas en la catedral de las Palmas de Gran Canaria
Authors: Lorenzo Lima Juan Alejandro
Published: November 2020

En este artículo se estudia de forma pormenorizada un retrato del arzobispo Francisco Javier Delgado y Venegas (1714-1781), contextualizándolo adecuadamente en la década de 1770. Responde a un encargo formulado por los miembros del cabildo eclesiástico de Santa Ana, quienes asumieron su coste para recordar la trayectoria de quien fue años antes un excelente patrocinador de las artes y obispo de la única diócesis de Canarias. La documentación aportada confirma su ejecución en Madrid por parte del pintor Francisco Cazas y las circunstancias que posibilitaron su traslado hasta Gran Canaria junto a otros bienes adquiridos en la Península.
De iconografía y vanguardia: la pintura de Antonio Povedano(1918-2008)
Authors: García-Luengo Manchado Javier
Published: November 2020

El presente artículo aborda la figura del artista prieguense Antonio Povedano, de quien se está celebrando el centenario de su nacimiento. Al hilo de tal efeméride y de la revisión que de su trayectoria y obra se está llevando a cabo en los últimos tiempos, se pretende contextualizar e insertar su producción pictórica en el debate entre tradición y modernidad, consustancial al arte español de la segunda mitad del siglo XX y primeros años del XXI. Se analizan pues las diferentes etapas y principales recursos iconográficos de su carrera, poniéndose de relieve su capacidad para hallar la renovación
estética en la tradición de su tierra de origen.
La decoración mural de Juan Miguel Sánchez en la parroquia de Santa Teresa: una aportación singular en el arte sacro sevillano del siglo XX
Authors: Palomo-Reina Juan
Published: November 2020

Las pinturas murales que Juan Miguel Sánchez Fernández realizó en 1961 para decorar el interior de la parroquia de Santa Teresa de Sevilla constituyen una aportación original y de gran modernidad en la pintura mural y el arte sacro sevillano del siglo XX. A través del análisis de los aspectos técnicos, formales e iconográficos de estas pinturas murales al fresco, el artículo pretende rescatar del olvido esta obra única, que no ha sido anteriormente estudiada, constatar su importancia para la historia de la pintura mural en España y ampliar el conocimiento sobre la trayectoria artística y biográfica de su autor.
El diseño industrial y la radio en “Baquelitas y otros plásticos. La colección Rafael Ortiz”
Authors: Martínez-Montiel Luis F.
Published: November 2020

“Baquelitas y otros plásticos. La Colección Rafael Ortiz”, iniciada hace casi veinte años, ha ido avanzando a medida que su conocimiento se hacía mayor, porque para Rafael Ortiz coleccionar es una forma más de aprender. El tiempo y el aprendizaje sobre materiales, objetos y diseñadores le han afinado el ojo y han centrado su interés cada vez más. Lo que comenzó como un simple pasatiempo está en proceso de convertirse en una de las colecciones españolas más importantes de objetos de plástico. En este ensayo, la atención se centra en la colección de radios y en la evolución de los diseñadores
industriales. Diseñadores, marcas y modelos de radio, que se mantienen en la colección, son analizados y valorados como parte del legado del siglo XX.
Virtual discussion on anaemia in chronic kidney disease
Authors: Barratt Jon , Bangura Bintu , Bhandari Sunil , Brown Chris , Hall Matthew , Mark Patrick , Mikhail Ashraf , Williams Jennifer Ann
Published: November 2020

A group of renal experts attended a round-table meeting to discuss anaemia in chronic kidney disease. Here, Jasmine Callaghan, Journal of Kidney Care (JKC) Editor, details the outcomes
Challenging COVID-19 times – Possibilities and limitations of law in regulation of health behavior of individuals
Authors: CAPÍKOVÁ, SILVIA , NOVÁKOVÁ MÁRIA
Published: November 2020

The paper focuses on the social assumptions of effectiveness and legitimacy of law and its current threats, which became more pronounced during the COVID-19 pandemic. The right to health is a fundamental human right. The protection of population health is one of the tasks and obligations of the state, arising from several international treaties. Law is currently one of the important regulatory mechanisms for the conduct of natural and legal persons. It is one of the important public health instruments that regulates activities that are or may be dangerous to human health, but also to control health behaviour, for example indirectly by taxing cigarettes or directly – by banning the sale of alcoholic beverages to minors. COVID-19 has caused a global pandemic with many casualties. Due to the mode of transmission and the high level of contagion, many countries have taken strict and unpopular restrictive measures that interfere with other human rights, in an effort to reduce mortality. COVID-19 appeared in Slovakia in social conditions, which according to current research are characterized by low trust in the judicial and legal system and state institutions, not a negligible degree of anomie and the tendency of the population to share and adopt conspiracy theories. Exercise of the right to freedom of opinion and expression together with informatization of society enables not only the effective dissemination of quality and professional information from experts and public bodies, but also health disinformation or hoaxes about the COVID-19 disease, which undermines the legitimacy of the adopted legislative measures and can play a negative role in efforts to protect right to health.
The state-individual relationship during COVID-19 pandemic – from the human rights point of view
Authors: Florek Iwona
Published: November 2020

Since the outbreak of the Covid-19 epidemic in November 2019 in Wuhan (China) countries experience negative impact of the coronavirus actions on their health care systems. Therefore different administrative regulations are imposed to flatten the disease curve, to ensure fluent and undisturbed work of health units. The goal of the article is to get a closer look at practical aspects of legal and administrative regulations that are imposed in different countries to prevent the spread of coronavirus and analyse them in the context of human rights restrictions. It is difficult, if not impossible, the give a simple answer whether or which restraints are needed. Therefore, the author aims at drawing attention on the slight borderline where the restrictions are necessary for the sake of health and where are they exaggeration of public authority’s power over individuals. The novum of the article is a look at the state-individual relationship according to the concept of W. Osiatyński in the situation of the Covid-19 epidemic. The research method used by the author is the analysis of the relationship between the state and the individual in terms of human rights, taking into account the provisions of law. The practical assessment of the implementation of the protection of individual rights was illustrated by the most recent press reports, both Polish and international.
Cation engineering for wide bandgap CH3NH3Pb (I1−xBrx)3 perovskite solar cells
Authors: Fathzadeh Atefeh , Abdollahi Nejand Bahram , Moravvej-Farshi Mohammad Kazem
Published: November 2020

We intend to demonstrate that the treatment of MA (=CH3NH3) Pb (I1−xBrx)3 perovskites with FA (H2N-CH=NH2) cations can enhance the perovskites photovoltaic characteristics. Besides, we propose a new route of bandgap engineering employing low-temperature vapor-assisted solution processes (VASP), reducing fabrication time and material usage. Using this proposed method, we synthesized MAPb (I1−xBrx)3 perovskite layers of 0.4≤x≤1 on mesoporous structures in the ambient atmosphere. Then, we fabricated five types of wide-bandgap perovskite solar cells (PSCs), employing five different molar ratios of PbI2: PbBr2, to tune the bandgaps in the range of 1.78 eV≤EG≤2.29 eV. Then, via spin-coating of FAI and FABr, we introduced FA cations into the perovskite samples and obtained higher quality FA1-yMAyMAPb (I1−xBrx)3 perovskites with smaller trap densities and recombination centers, broader substrate coverage, fewer grain boundaries, a smaller number of pinholes, and hence PSCs with improved photovoltaic performances. The highest efficiencies (11.86% and 12.49%) obtained for untreated and treated samples with x = 0.4 are far from the highest PCEs reported in the literature to date. Nonetheless, the enhancements we observed in the PSCs’ short circuit currents, open-circuit voltages, and PCEs plus the reduction of up to 0.039 in their hysteresis-indices signify the proposed fabrication method and FA treatment can be beneficial to the further development of the perovskite-based solar cells and light emitting diodes.
Black soybean tempeh and purple sweet potato improve sperm quality in streptozotocin-induced diabetic rats
Authors: Gofur Abdul , Witjoro Agung , Arifah Siti Nur , Atho'illah Mochammad Fitri , Annisa Yuslinda , Lestari Sri Rahayu
Published: November 2020

Background and Aim: Hyperglycemia increases advanced glycation end-product (AGE) production, and the activity of receptor for AGE (RAGE) in testis, which leads to testicular histopathological damage and infertility. This research investigated the effect of black soybean tempeh (BST), purple sweet potato (PSP), and its combination on AGE and RAGE expression and spermatozoa quality in streptozotocin (STZ)-induced diabetic rats. Materials and Methods: The rats were given high-fat diets for 5 weeks, then were injected intraperitoneally with multiple low doses of STZ (30 mg/kg body weight). Diabetes mellitus (DM) rats were divided into seven groups: DM, DM+glibenclamide, DM+BST, DM+PSP, and DM+combination of BST and PSP in ratio 1:3, 2:2, and 3:1 as C1, C2, and C3, respectively. The rats were treated for 30 days. Testicular AGE and RAGE expression and spermatozoa quality were measured. Results: The combination of BST and PSP significantly decreased AGE and RAGE expression in testicular organs and improved spermatozoa quality compared to the normal group. Conclusion: The combination of BST and PSP can be used as future alternatives to improve spermatozoa quality in DM patients.
Coagulation testing: Comparison of portable (CoaguChek® XS) and automated coagulation analyzer in healthy cats
Authors: Tonthong Sireeporn , Rungpupradit Jetsada
Published: November 2020

Background and Aim: The CoaguChek® XS (CCX) is a portable coagulation analyzer that is widely used to monitor prothrombin time (PT) in human patients taking oral anticoagulants. It can also be reliably used for screening dogs when PT is in the normal range. Efficacy of the portable CCX coagulation analyzer was evaluated for testing PT in healthy cats and the normal range was established.

Materials and Methods: Blood samples of 82 cats were collected from the jugular vein and PT was measured using both the CCX and an automated coagulation analyzer (ACA). Spearman's correlation was used to measure the strength and direction of association between the two analyzers, while limits of agreement were assessed utilizing Bland-Altman analysis.

Results: Range of PT using the CCX was 10.1-14.1 s. Correlation between the two analyzers was moderate but significant (r=0.3465, p=0.0014). Mean difference between CCX-PT and ACA-PT was 1.624 s and standard deviation was 0.890 with 95.1% of the samples falling within the limits of agreement.

Conclusion: The CCX is a portable, easy to use coagulation analyzer that requires a small volume of blood and gives results within 1 min. Results showed moderate correlation and good agreement with a standard automated laboratory analyzer. The CCX can be used for screening coagulation testing when PT is in the normal range for cats. However, testing accuracy of the CCX in abnormal PT cats should be further investigated before diagnostic coagulopathy applications.
A közlekedési eszközpark és infrastruktúra hasznos élettartamát tudományos alapon növelő technológia kidolgozása a BKV ZRt. számára
Authors: Fiáth Attila , Nagy Vince , Takács Péter , Balogh László , Bálint Ágnes , Nagy Balázs , Dinya Mariann
Published: November 2020

A budapesti közösségi közlekedési eszközpark jelentős része meghaladta beszerzéskor tervezett hasznos élettartamát. Ezen eszközök továbbüzemeltetése a jelenleg rendelkezésre álló információk alapján még hosszú ideig szükséges, ezért – a hasznos élettartam növelésére vonatkozó komplex és teljes körű módszertan hiányában – 2012-ben a Budapesti Közlekedési Zártkörűen Működő Részvénytársaság (továbbiakban BKV Zrt., Társaság) vezetése szakmai döntést hozott e hiány pótlását szolgáló, tudományosan megalapozott rendszer kidolgozására. A hasznos élettartamot tudományos alapon növelő módszertan és technológia kidolgozására vonatkozó együttműködés eredményeképpen előállt az úgynevezett tudományos alapú továbbüzemeltetési protokoll (továbbiakban: TTP) modell. Az új, időtálló modell a továbbüzemeltetés feltételeit műszaki, biztonsági és gazdasági szempontok komplex rendszerbe integrálásával, objektív értékelési módszertan alapján határozza meg, és ezáltal a Társaság menedzsmentje szerint vállalhatónak ítélt szintre mérsékelve az üzemeltetői kockázatok és felelősség mértékét.
El marco jurídico argentino del ordenamiento territorial: ¿propicia un desarrollo sostenible?
Authors: Gimelfarb Leonor Selena
Published: November 2020

Este trabajo indaga cómo se instrumenta jurídicamente la consecución del desarrollo sostenible mediante el ordenamiento territorial. Su objetivo fue contribuir al conocimiento del marco jurídico argentino del ordenamiento territorial, examinando si propicia un desarrollo sostenible. Se realizó un estudio de caso, relevando y analizando las 31 leyes que conforman este marco jurídico. Se elaboró un marco conceptual que profundiza en la vinculación entre ordenamiento territorial y desarrollo sostenible, a partir del cual se formularon diez dimensiones de análisis y 27 indicadores. Su aplicación a las leyes relevadas permitió identificar normas que propician un desarrollo sostenible. El análisis mostró que el marco jurídico vigente contiene un número reducido de tales normas y no pueden considerarse un instrumento adecuado de desarrollo sostenible. El trabajo concluye con la recomendación de desarrollar los lineamientos sobre  ordenamiento ambiental del territorio, establecidos por la Ley General del Ambiente, mediante una ley sectorial de presupuestos mínimos.
Relación entre la presencia del portero y las variables pedagógicas que definen las tareas en el fútbol. Un estudio de caso
Authors: Gamonales José M. , León Kiko , Muñoz-Jim´énez Jesús
Published: November 2020

This research aims to analyze the pedagogical variables included in the training tasks designed by the soccer-base coach, Benjamin category (age between 9 and 10 years), regarding the presence or not of the goalkeeper. To do this, a total of 46 training tasks framed during 2 months of the training stage were analyzed. For the categorization of tasks, the SIATE tool was used, to analyze the pedagogical variables: Presence of Goalkeeper (PG), Game Situation (GS), Game Phase (GP), Content Type (CONT-T), Sports Initiation Medium (SIM), Opposition Level (OL) and Line of Play (LJ). The results show that the coach designs 8 x 8, mixed and competitive training tasks with the presence of a goalkeeper, and 1 x 0 training tasks, complex application exercise for warm-up without the presence of a goalkeeper. Also, there are significant differences between the variable presence of goalkeeper and the coach’s way of acting.
The advantages of the dental operative microscope in restorative dentistry
Authors: Bud Marius , Jitaru Stefan , Lucaciu Ondine , Korkut Bora , Dumitrascu-Timis Lucia , Ionescu Corina , Cimpean Sanda , Delean Ada
Published: November 2020

Magnification devices improve direct and indirect vision and precision being significantly higher in microscope use compared to the loupes. Dental loupes are the most commonly used devices for magnification, due to the more affordable prices and the ease of use without major changes in the working protocol and ergonomics. Loupes primary benefits reported refers to ergonomics and posture, restoration evaluation/detection and overall treatment quality. There are some disadvantages that limit the use of loupes among dentists: lack of fixed position (fine movements of the dentist's head disturb the image of the magnified operating field); the need to change the loupes to achieve different magnification. On the contrary, the use of a dental microscope require minimum adjustment and effort so as to reduce postural deviation while working.

It has been more than 30 years since dental practitioners raised the issue of using dental operating microscopes (DOM) in restorative dentistry, identifying the benefits of magnification in diagnosis and treatment steps. The growth is evident in recent years, maybe because of the familiarity of dentists with dental microscopes which have already become implicit endowment for endodontic specialists. Fiber optic lighting is the key factor that complements the magnification offered by the microscope so that treatments can now be performed under increased safety conditions and in conditions of significantly higher quality than in the past.

Since the beginning of the 2000s the principles of minimally invasive dentistry have been widely promoted in dentistry. These principles are major impetus for the use of microscope by dentists. Working with magnification leads dentists to be more conservative with dental tissues.
Asymptomatic COVID–19 cancer patients incidentally discovered during F18-FDG PET/CT monitoring
Authors: Piciu Andra , Manole Simona , Piciu Doina , Dreve Teodora , Roman Andrei
Published: November 2020

Background. The aim of the study was to present the PET/CT imaging features in a small series of asymptomatic patients with known cancer pathologies, infected with the SARS-CoV-2 virus, which were incidentally discovered during their monitoring scan of F18-FDG PET/CT.

Methods. We included in our study a number of five cases (3 female and 2 male) out of 478 patients examined by F18-FDG PET/CT between March – April 2020, with confirmed diagnostic of cancer. Four patients had lung damages suggestive for the mentioned viral infection and 1 patient had multiple lung metastases from thyroid cancer. All patients were asymptomatic for acute respiratory disease at the time of examination, being subsequently confirmed for the viral infection by specific PCR analysis.

Results. The asymptomatic positive SARS-CoV-2 cancer patients discovered incidentally in PET/CT F18-FDG represent 0.83% and their imaging characteristics were suggestive for high FDG activity in the lung despite the lack of respiratory symptoms.

Conclusion. The SARS CoV-2 viral infection in asymptomatic cancer patients is a very rare possibility, but represents a challenging scenario both for the differential diagnosis in cancer and also for the epidemiologic context.
Modern view on treatment of patients with fibrocystic mastopathy
Authors:   Ukrainian National Cancer Institute, Kyiv, Smolanka I.I. , Loboda A.D. ,   Ukrainian National Cancer Institute, Kyiv
Published: November 2020

The aim of the study: to determine the effectiveness of the drug Epigalin® Brest in the treatment of fibrocystic breast disease in women. Materials and methods. The study included 50 women with an established diagnosis of fibrocystic breast disease (diffuse cystic mastopathy). All women complained of pain and swelling of both breast 3-20 days before the start of menstruation. By blind randomization, all women were divided into 2 groups. Patients of the first group used the drug Epigalin® Brest 1 tablet 2 times a day for three months. Patients of the second group used the drug prostrate summer cypress on the approved user scheme. Patients of both groups did not differ in age (from 22 to 48 years, mean age 35 years). All patients during General examination were performed ultrasound of the breast, and patients older than 40 years also performed the mammogram. Patients of both groups were found multiple cysts in both breasts, the size of which ranged from 3 mm to 22 mm. the average size of the cysts groups were comparable. To assess the effectiveness of treatment in both groups was determined by three parameters: 1. Pain in the Breasts, which were evaluated on a scale from 0 (no pain) to 10 (unbearable pain). 2. Tissue density breast, to determine which was performed by transient elastography (kPa). 3. The average diameter of the cyst. Results. According to the study in the first group identified the implementation of a positive effect of the drug Apigalin Brest. Patients in this group there was a decrease in the average degree of pain, i.e. the patient almost did not feel pain before menstruation, and the complete absence of cystic elements in the Breasts was detected in 90% of patients. No patient noted the deterioration of the breast during the observation. Patients of the second group the average degree of pain, but 10% of the patients noted aggravation of pain syndrome after discontinuation of the drug prostrate summer cypress. In 15% of patients in this group appeared again cysts, and their average diameter began to increase. Tissue density of the breast tended to increase. Conclusion. 1. Complex herbal preparation Epigalin® Brest is effective in the treatment of mastitis. In the case of regular use Apigalin Brest reduce by 68% the presence of cystic component in women with mastopathy. 2. Epigalin® Brest with regular use reduces the density of the tissue of the breast, realizing the function of oncoprotektor. 3. Epigalin® Brest significantly reduces pain before menstruation, which considerably improves the quality of life. Key words: mastopathy, pain, breast gland, treatment, Epigalin® Brest.
Ovarian reserve in infertile women of reproductive age with non-operated ovarian endometriomas
Authors:   Odessa National Medical University, Ukraine, Dubinina V.G. , Nosenko О.М. ,   Odessa National Medical University, Ukraine, Chuzhyk O.I. ,   Shupyk National Medical Academy of Postgraduate Education, Kуiv, Ukraine, Grytsenko G.S. ,   Odessa National Medical University, Ukraine
Published: November 2020

The objective: of the study was to investigate the indicators of ovarian reserve in infertile women of reproductive age with non-operated ovarian endometriomas more than 3 cm in diameter. Patients and methods. It were examined 63 patients of reproductive age with ovarian endometriosis, including 33 with unilateral ones and 30 with bilateral. The control group consisted of 30 conditionally somatically healthy women of reproductive age with secondary tubal infertility, with regular ovulatory menstrual cycle. All the women were operated on. Prior to the surgery it were studied biochemical and sonographic markers of ovarian reserve, and after pathological study of operational materials – histological markers. Results. It was registered decrease in biochemical, ultrasonographic and histological indicators of ovarian reserve compared to control. Conclusion. The authors conclude that endometriosis directly affects ovarian reserve and ovarian reserve should be assessed not only after it, but before surgery in women with endometriomas and reproductive disorders. It is important to determine the tactics of their management. Key words: endometrioma, ovary, ovarian reserve, operation, Anti-Mьllerian hormone, inhibin B, FSH, estradiol, the number of antral follicles.
The complex of therapeutic and preventive measures for women with non-alcoholic fatty liver disease in preparation for ART programs
Authors:   Shupyk National Medical Academy of Postgraduate Education, Kуiv, Ukraine, Boychuk A.G.
Published: November 2020

The objective: To evaluate the effectiveness of complex therapeutic and preventive measures for women with non-alcoholic fatty liver disease in preparation for ART programs. Materials and methods. To evaluate the effectiveness of therapeutic and preventive measures on the basis of the prediction algorithm in women with infertility and non-alcoholic fatty liver disease (NAFLD) identified 60 women with a high risk of inefficiencies ART. The method of randomization, patients were divided into: basic group - 30 women with a recommended set of preparations for the holding of ART, the comparison group - 30 women with preparations for ART according to the Ministry of Health protocols. Results. Application reference system in women with infertility and NAFLD, which includes forecasting inefficiency ART and additional therapeutic and preventive measures to include gepatoprotektors, acid ursodeoxycholicum drugs, L-arginine, щ-3 fatty acids and probiotics, helped to improve the overall condition of the woman, a liver condition, cardiovascular regulation reduce symptoms of dysbiosis, hormonal status and reproductive system, as a result, increase the effectiveness of ART programs to population-wide level (pregnancy occurred in 36.7% of women). Conclusions. Prove safety and high efficiency of complex therapeutic and preventive measures for women with infertility and NAFLD can be recommended for implementation in practice of reproductive medicine clinics, which will increase the effectiveness of ART, to preserve a woman’s health. Key words: infertility, assisted reproductive technologies, non-alcoholic fatty liver disease, treatment.
To question of prophylaxis of the complicated motion of pregnancy at insufficiency and deficit of D-vitamin
Authors:   Danylo Halytskyy Lviv National Medical University, Lviv, Ukraine, Pyrohova V. , Shurpyak S. ,   Danylo Halytskyy Lviv National Medical University, Lviv, Ukraine, Zhemela N.I. ,   Danylo Halytskyy Lviv National Medical University, Lviv, Ukraine, Holota L. ,   Danylo Halytskyy Lviv National Medical University, Lviv, Ukraine
Published: November 2020

Lviv national medical University named Danylo Galitsky In the article there are the lighted up questions of terminology, classification, diagnostics and treatment of syndrome of chronic pelvic pain. The features of diagnostics and differentiation process are considered in relation to the syndrome of chronic pelvic pain in gynecological practice. An accent is done, that treatment of chronic pelvic pain is fully determined a verification of basic disease, if it be impossible to find out primary cause (idiopathic genesis of chronic pelvic pain), symptomatic therapy is conducted. Key words: chronic pelvic pain, pelvic venocongestion, genital endometriosis, dysmenorrhea, pelvic inflammatory diseases.
Mastodynia in the context of breast diseases: complex approach for diagnostic and treatment in reproductive age women
Authors:   Zaporozhye State Medical University, Ukraine, Syusyuka V. , Neryanov K. ,   Zaporozhye State Medical University, Ukraine, Kyryakova P. ,   Diagnostic and treatment center YULIS, Zaporozhye, Ukraine, Musin I. ,   Diagnostic and treatment center YULIS, Zaporozhye, Ukraine, Bykov О. ,   Diagnostic and treatment center YULIS, Zaporozhye, Ukraine
Published: November 2020

The objective: to evaluate effectiveness of complex treatment of dyshormonal breast diseases with mastodynia in reproductive age women. Patients and methods. 82 women aged from 23 to 45 years with dyshormonal breast diseases (DBD) accompanied with mastodynia took part in the trial. Diagnosis has been verified based on the patients ‘complaints, clinical observation of mammary glands, instrumental, clinic and laboratory investigation methods (ultra sound examination, aspirational biopsy, bilateral mammography). Assessment of mastodynia severity conducted using visual analogue pain scale (VAPS) in points. Diagnostic of anxiety level among examined women carried out by using Spielberg – Hanin methodology. All patients got Vitokan (Fita®) 30 drops 3 times per day 20–30 min before meals in combination with local transdermal gel contained 1% of micronized progesterone - Progestogel® (Besins Healthcare). Treatment duration was 3 months. Patients’ examination conducted in 1–3–6 months. Results. According to the Medical Center data, it was observed that diffuse dyshormonal breast diseases occupied leading positions among all breast pathologies reaching 45–47% share. All women included in the trial had complaints on cycle bilateral breast pain (mastodynia) which appeared 8–10–12 days before menses. Diffuse seals and tenderness have been discovered via palpation. Diffuse fibrocystic hyperplasia with dominated cystic component was found in 47.6% of women and was recognized as most frequent pathology based on the results of ultra-sound breast examination. Combined treatment of Progestogel® and Vitokan leads to reduction of mastodynia symptoms in 76.8% women after the 1st month of treatment/dynamic observation and in 95% of women after the next 3 months. It was shown statistically significant decrease in the level of situational anxiety after conducted treatment that led to improvement in mood. Conducted trial defined women’s subjective evaluation based on their complaints as the key factor of treatment effectiveness All objective methods of patient’s examination have secondary importance. Conclusions. High effectiveness of Progestogel® and Vitokan combined therapy has positive impact on clinical presentation, psycho-emotional condition (decreased level of anxiety) and proved by objective and instrumental methods of examination with no side effects. This fact provides evidence for using proposed combination for treatment of dishormonal breast diseases. Key words: dishormonal breast disease, mastodynia, treatment, herbal medicine, progesterone, Prozhestozhel, Vitokan.
Nerve-sparing radical hysterectomy in patients with infiltrative cervical cancer
Authors:   Ukrainian National Cancer Institute, Kyiv, Dermenzhy T. , Svintitskiy V. ,   Ukrainian National Cancer Institute, Kyiv, Nespryadko S. ,   Ukrainian National Cancer Institute, Kyiv, Legerda L. ,   Ukrainian National Cancer Institute, Kyiv, Stahovsky E. ,   Ukrainian National Cancer Institute, Kyiv, Iatsyna A. ,   SI Institute of Urology of the NAMS of Ukraine, Kyiv, Kabanov A. ,   Taras Shevchenko National University of Kyiv, Ukraine
Published: November 2020

The objective: to improve an effectiveness of therapy and quality of life of patients with infiltrative cervical cancer using radical hysterectomy accomplished with nerve-sparing methodology. Patients and Methods: Ninety patients with histologically verified infiltrative cervical cancer were cured with radical hysterectomy (RHE) in the Department of Oncogynecology of National Cancer Institute (Kyiv, Ukraine) in 2012-2016. The age of the patients was from 26 to 65 years (an average age of 42.61±1.06). The patients were distributed in 2 groups: group I treated with nerve-sparing radical hysterectomy (NSRHE), 45 patients, the main group; group II treated with radical hysterectomy (RHE III), the control group, 45 patients. The prognostic indexes in the groups were similar. Results. NSRHE that included the dissection of cardinal ligament, separation of dorsal and anterior layers of uterovesical ligament allowed separate uterine branch of inferior hypogastric plexus, preserve an innervation of urinary bladder and prevent the malfunction of its contractile function at postoperative period. Conclusion. The data of the urodynamic study using cystomanometry performed at pre- and early operative periods have shown that surgical treatment of patients with infiltrative cervical cancer with preservation of the major elements of pelvic autonomic plexuses allows significantly decrease the rate of postoperative urogenical malfunctions. Key words: nerve-sparing radical hysterectomy, cervical cancer, cystomanometry.