bluuebunny/crossref_metadata_2025 huggingface dataset:
RETRACTED ARTICLE: Sirt7 promotes gastric cancer growth and inhibits apoptosis by epigenetically inhibiting miR-34a
Authors: Zhang Shun , Chen Ping , Huang Zuoan , Hu Xiaorong , Chen Mengting , Hu Shanshan , Hu Yixin , Cai Ting
Published: April 2015

Gastric cancer is the fourth most common cancer worldwide, with a low 5-year survival rate. Epigenetic modification plays pivotal roles in gastric cancer development. However, the role of histone-modifying enzymes in gastric cancer remains largely unknown. Here we report that Sirt7, a NAD+-dependent class III histone deacetylase, is over-expressed in human gastric cancer tissues. Sirt7 level is significantly correlated with disease stage, metastasis and survival. Knockdown of Sirt7 in gastric cancer cells inhibits cell proliferation and colony formation in vitro. In vivo subcutaneous xenograft results also show that Sirt7 knockdown can markedly repress gastric cancer cell growth. In addition, Sirt7 depletion induces apoptosis in gastric cancer cells via up-regulating expression of pro-apoptotic proteins and down-regulating anti-apoptotic proteins. Mechanically, Sirt7 binds to the promoter of miR-34a and deacetylases the H3K18ac, thus represses miR-34a expression. Reversely, depletion of miR-34a inhibits gastric cancer apoptosis induced by Sirt7 knockdown and restores cellular capacity of proliferation and colony formation. miR-34a depletion reduces Sirt7-knockdown-induced arrest of gastric growth. Finally, miR-34a is tightly associated with survival of patients with gastric cancer.
Photodynamic behavior of electronic coupling in a N-methylformamide dimer
Authors: Zámečníková Martina , Nachtigallová Dana
Published: April 2015

The role of the bridging water molecules has been studied during the excited state photodynamics of a N-methylformamide dimer in complex with water molecules employing the complete active space self-consistent field (CASSCF) and CAS perturbation theory (CASPT2) methods.
Induction of the pi class of glutathione S-transferase by carnosic acid in rat Clone 9 cells via the p38/Nrf2 pathway
Authors: Lin Chia-Yuan , Wu Chi-Rei , Chang Shu-Wei , Wang Yu-Jung , Wu Jia-Jiuan , Tsai Chia-Wen
Published: April 2015

CA up-regulates the expression of GSTPviathe p38/Nrf2/GPEI pathway in Clone 9 cells.
The role of transition metal transporters for iron, zinc, manganese, and copper in the pathogenesis of Yersinia pestis
Authors: Perry Robert D. , Bobrov Alexander G. , Fetherston Jacqueline D.
Published: April 2015

Yersinia pestis, the causative agent of bubonic, septicemic and pneumonic plague, encodes a multitude of Fe transport systems.
First-principles prediction of graphene/SnO2 heterostructure as a promising candidate for FET
Authors: Zhang Run-wu , Zhang Chang-wen , Luan Hang-xing , Ji Wei-xiao , Wang Pei-ji
Published: April 2015

Very recently, graphene/SnO2 heterostructures (G/SnO2 HTSs) were successfully synthesized experimentally.
Imaging viscoelastic properties of live cells by AFM: power-law rheology on the nanoscale
Authors: Hecht Fabian M. , Rheinlaender Johannes , Schierbaum Nicolas , Goldmann Wolfgang H. , Fabry Ben , Schäffer Tilman E.
Published: April 2015

Force clamp force mapping (FCFM): an AFM technique for mapping viscoelastic properties of live cells.
Deformation of a floating liquid marble
Authors: Ooi Chin Hong , Vadivelu Raja K. , St John James , Dao Dzung Viet , Nguyen Nam-Trung
Published: April 2015

We report the analytical and experimental characterisation of the deformation of a liquid marble floating on a liquid surface.
Highly luminescent CuGaxIn1−xSySe2−y nanocrystals from organometallic single-source precursors
Authors: Kluge Oliver , Plante Ilan Jen-La , Diab Mahmud , Volokh Michael , Teitelboim Ayelet , Mokari Taleb
Published: April 2015

Synthesis and characterization of highly luminescent near-infrared CuGaxIn1−xSySe2−y nanocrystals obtained from organometallic single-source precursors.
A novel electrochemical aptamer–antibody sandwich assay for lysozyme detection
Authors: Ocaña Cristina , Hayat Akhtar , Mishra Rupesh , Vasilescu Alina , del Valle Manel , Marty Jean-Louis
Published: April 2015

In this paper, we have reported a novel electrochemical aptamer–antibody based sandwich biosensor for the detection of lysozyme.
Comparison of different analytical classification scenarios: application for the geographical origin of edible palm oil by sterolic (NP) HPLC fingerprinting
Authors: Pérez-Castaño Estefanía , Ruiz-Samblás Cristina , Medina-Rodríguez Santiago , Quirós-Rodríguez Verónica , Jiménez-Carvelo Ana M. , Valverde-Som Lucía , González-Casado Antonio , Cuadros-Rodríguez Luis
Published: April 2015

The comparison of scenarios of classification is highlighted. This term is referred to the combination of classifiers and analytical data.
Determination of Se(iv) as a 5-nitropiazselenol complex by adsorptive stripping voltammetry at an in situ plated bismuth film electrode
Authors: Sharifian Parisa , Aliakbar Alireza
Published: April 2015

In this paper a simple, selective, sensitive and reproducible stripping method based on adsorption of Se(iv) in the form of a 5-nitropiazoselenol complex at the surface of anin situplated bismuth film electrode was introduced.
Noninvasive theranostic imaging of HSV-TK/GCV suicide gene therapy in liver cancer by folate-targeted quantum dot-based liposomes
Authors: Shao Dan , Li Jing , Pan Yue , Zhang Xin , Zheng Xiao , Wang Zheng , Zhang Ming , Zhang Hong , Chen Li
Published: April 2015

We have successfully developed folate-targeting liposomes for effective and safe HSV-TK suicide gene theranostics.
Organocatalyzed benzannulation for the construction of diverse anthraquinones and tetracenediones
Authors: Somai Magar Krishna Bahadur , Xia Likai , Lee Yong Rok
Published: April 2015

An efficient one-pot synthesis of anthraquinones and tetracenediones was achieved by l-proline catalyzed benzannulation of commercially available 1,4-naphthoquinones or 1,4-anthracenedione with a variety of α,β-unsaturated aldehydes in good to excellent yield.
Laser induced SERS switching using plasmonic heating of PNIPAM coated HGNs
Authors: Kearns H. , Shand N. C. , Faulds K. , Graham D.
Published: April 2015

Laser induced plasmonic heating of PNIPAM coated HGNs turning ‘on and off’ the SERS enhancement.
Direct insights into metal-induced conductivity enhancement in conducting metallopolymers
Authors: Nguyen Minh T. , Holliday Bradley J.
Published: April 2015

The role of the metal centers in a conducting metallopolymer was elucidated using a metal-free polymer and the corresponding metallopolymer.
Near infrared light mediated release of doxorubicin using upconversion nanoparticles
Authors: Michael Dcona M. , Yu Qing , Capobianco John A. , Hartman Matthew C. T.
Published: April 2015

Lanthanide doped upconversion nanoparticles grafted with a photocaged analog of doxorubicin allow near IR-release of doxorubicin.
Synthesis and labeling of α-(2,9)-trisialic acid with cyanine dyes for imaging of glycan-binding receptors on living cells
Authors: Zhang Xiao-tai , Gu Zhen-yuan , Liu Libing , Wang Shu , Xing Guo-wen
Published: April 2015

The cyanine tagged oligosialic acid was utilized as an efficient fluorescent probe to image the glycan-binding receptors on PC-12 cells.
Enantioselective 1,4-addition of cyclopropylboronic acid catalyzed by rhodium/chiral diene complexes
Authors: Takechi Ryosuke , Nishimura Takahiro
Published: April 2015

Rhodium-catalyzed asymmetric addition of cyclopropylboronic acids to electron-deficient alkenes proceeded to give high yields of the corresponding 1,4-addition products with high enantioselectivity.
Intramolecular transcyclometallation: the exchange of an aryl–Pt bond for an alkyl–Pt bond via an agostic intermediate
Authors: Shaw Paul A. , Phillips Jessica M. , Newman Christopher P. , Clarkson Guy J. , Rourke Jonathan P.
Published: April 2015

Oxidation of a square-planar platinum complex leads to a five coordinate cationic intermediate that can be stabilized and trapped out via an agostic interaction with the alkyl chain of a ligand.
Synthesis and anticancer properties of fucoidan-mimetic glycopolymer coated gold nanoparticles
Authors: Tengdelius Mattias , Gurav Deepanjali , Konradsson Peter , Påhlsson Peter , Griffith May , Oommen Oommen P.
Published: April 2015

Gold nanoparticles coated with fucoidan-mimetic glycopolymers were synthesized that displayed good colloidal stability and promising anti-cancer properties.
Large impact of reorganization energy on photovoltaic conversion due to interfacial charge-transfer transitions
Authors: Fujisawa Jun-ichi
Published: April 2015

Interfacial charge-transfer (ICT) transitions are expected to be a novel charge-separation mechanism for efficient photovoltaic conversion featuring one-step charge separation without energy loss.
The first UV absorption band for indole is not due to two simultaneous orthogonal electronic transitions differing in dipole moment
Authors: Catalán Javier
Published: April 2015

Polarization of the indole in glycerol: at 223 K (1LbwithP0= 0.38) and at 283 K (1LawithP0= 0.18).
DNA-assisted photoinduced charge transfer between a cationic poly(phenylene vinylene) and a cationic fullerene
Authors: Park Youngil , Liu Zhongwei , Routh Prahlad K. , Kuo Cheng-Yu , Park Young-Shin , Tsai Hsinhan , Martinez Jennifer S. , Shreve Andrew P. , Cotlet Mircea , Wang Hsing-Lin
Published: April 2015

DNA promotes the efficient photoinduced charge transfer between a water-soluble, cationic conjugated polymer and cationic fullerene.
Self-assembly of photoswitchable diblock copolymers: salt-induced micellization and the influence of UV irradiation
Authors: Zhang Jing , Zhang Yue , Chen Feiyang , Zhang Weiyao , Zhao Hanying
Published: April 2015

Inorganic salts are able to induce micellization of PEG-b-PSPMA in a 10 : 1 DMF/water mixture upon UV irradiation. The complex formation between inorganic ions and MC isomers plays a key role in the self-assembly process.
Long-lived and oxygen-responsive photoluminescence in the solid state of copper(i) complexes bearing fluorinated diphosphine and bipyridine ligands
Authors: Nishikawa Michihiro , Wakita Yuri , Nishi Tatsuya , Miura Takumi , Tsubomura Taro
Published: April 2015

Luminescence properties of a family of newly synthesized copper(i) complexes were investigated. The luminescence in the solid state is highly oxygen responsive.
Multifunctional luminescence properties of co-doped lanthanide metal organic frameworks
Authors: Xing Shanghua , Zeng Guang , Liu Xiaomin , Yang Fen , Hao Zhiqiang , Gao Wei , Yang Yulin , Wang Xiuru , Li Guanghua , Shi Zhan , Feng Shouhua
Published: April 2015

Multifunctional luminescent materials of six Ln-MOFs have been designed and synthesized by the co-doping strategy. Thus a wide range of light emitting spectra and different temperature-dependent luminescence behavior were displayed.
DFT characterization on the mechanism of sulfoxidation with H2O2catalyzed by tetranuclear peroxotungstates [XO4{WO(O2)2}4]n−(X = SiIV, PV, SVI, AsV, and SeVI)
Authors: Zhu Bo , Yan Li-Kai , Guan Wei , Su Zhong-Min
Published: April 2015

Tetranuclear peroxotungstates exhibit highly efficient sulfoxidation. DFT calculations disclose the mechanism of sulfoxidation with H2O2catalyzed by [XO4{WO(O2)2}4]n−(X = SiIV, PV, SVI, AsV, and SeVI).
Highly efficient degradation of organic dyes by palladium nanoparticles decorated on 2D magnetic reduced graphene oxide nanosheets
Authors: Li Siliang , Li Hua , Liu Jian , Zhang Haoli , Yang Yanmei , Yang Zhengyin , Wang Linyun , Wang Baodui
Published: April 2015

We report a novel and effective strategy to synthesize Pd/Fe3O4-PEI-RGO nanohybrids for highly efficient degradation of organic dyes.
An in vitro model of the tumor–lymphatic microenvironment with simultaneous transendothelial and luminal flows reveals mechanisms of flow enhanced invasion
Authors: Pisano M. , Triacca V. , Barbee K. A. , Swartz M. A.
Published: April 2015

This paper elucidates mechanisms of flow-mediated tumor invasion into lymphatics with a new in vitro model that integrates both interstitial and luminal flows.
Inclusion bodies and pH lowering: as an effect of gold nanoparticles in Streptococcus pneumoniae
Authors: Ortiz-Benitez Edgar Augusto , Carrillo-Morales Mariana , Velázquez-Guadarrama Norma , Fandiño-Armas Jesús , Olivares-Trejo José de Jesús
Published: April 2015

Streptococcus pneumoniae is a human pathogen whose principal virulence factor is its capsule. This structure allows the bacterium to evade the human immune system. Treatment of infections caused by this bacterium is based on antibiotics; however, the emergence of antibiotic-resistant strains makes this task increasingly difficult. Therefore, it is necessary to investigate new therapies, such as those based on gold nanoparticles, for which unfortunately the mechanisms involved have not yet been investigated. As far as we know, this study is the first that attempts to explain how gold nanoparticles destroy the bacterium Streptococcus pneumoniae. We found that the mean particle size was an important issue, and that the effect on the bacterium was dose-dependent. Cellular growth was inhibited by the presence of the nanoparticles, as was cell viability. The pH of the bacterial growth media was acidified, but interestingly the reactive species were not affected. A transmission electron microscopy analysis revealed the presence of inclusion bodies of gold nanoparticles within the bacterium. We present the first findings that attempt to explain how gold nanoparticles lyse Gram-positive bacteria.
Combined chemo- and photo-thermal therapy delivered by multifunctional theranostic gold nanorod-loaded microcapsules
Authors: Chen Haiyan , Di Yingfeng , Chen Dan , Madrid Kyle , Zhang Min , Tian Caiping , Tang Liping , Gu Yueqing
Published: April 2015

Synthesis and characterization of multifunctional theranostic microcapsules for combined chemotherapy and photothermal therapy.
Silver salts and DBU cooperatively catalyzed nucleophilic addition/cyclization of propargylic alcohols with trifluoromethyl ketones
Authors: Wang Jingjing , Kong Wei-Guang , Li Feng , Liu Jie , Shen Qin , Liu Lantao , Zhao Wen-Xian
Published: April 2015

A general and efficient synthesis of trifluoromethyl substituted 5-alkylidene-1,3-dioxolane using a silver salt and DBU cooperatively catalyzed nucleophilic addition/cyclization of propargylic alcohols and trifluoromethyl ketones is described.
Galacto configured N-aminoaziridines: a new type of irreversible inhibitor of β-galactosidases
Authors: Alcaide Anna , Trapero Ana , Pérez Yolanda , Llebaria Amadeu
Published: April 2015

N-Aminoaziridines are potent irreversible inhibitors of galactosidases.
Novel pH-tunable thermoresponsive polymers displaying lower and upper critical solution temperatures
Authors: Cai Xin , Zhong Liang , Su Yue , Lin Shaoliang , He Xiaohua
Published: April 2015

Novel pH-tunable thermoresponsive 3-azido-2-hydroxypropyl methacrylate-based polymers displaying LCST and UCST in phosphate buffer solutions were successfully synthesized by ATRP.
Versatile side chain modification via isocyanide-based multicomponent reactions: tuning the LCST of poly(2-oxazoline)s
Authors: Sehlinger Ansgar , Verbraeken Bart , Meier Michael A. R. , Hoogenboom Richard
Published: April 2015

Poly(2-oxazoline)s are receiving large current interest based on their potential use in biomedical applications. Here we report a novel, straightforward route towards functional poly(2-oxazoline)s by Passerini and Ugi reactions.
Effects of a thermally stable chlorophyll extract from diatom algae on surface textured Si solar cells
Authors: Chen Chiang-Ting , Hsu Fang-Chi , Huang Jeng-Yeh , Chang Chi-Yuan , Chang Tsung-Yuan , Lin Hsiu-Mei , Lin Tai-Yuan , Chen Yang-Fang
Published: April 2015

We present the effects of a chlorophyll extract from diatom algae as a spin-coating anti-reflection layer on surface textured silicon solar cells.
Synthesis of D–A polymers with a disilanobithiophene donor and a pyridine or pyrazine acceptor and their applications to dye-sensitized solar cells
Authors: Ohshita Joji , Adachi Yohei , Tanaka Daiki , Nakashima Makoto , Ooyama Yousuke
Published: April 2015

D–A polymers with disilanobithiophene (DSBT) as the donor were prepared. TiO2 electrodes were treated with the polymer solutions to provide polymer-attached TiO2. The resulting modified electrodes were applied to dye-sensitized solar cells.
Palladium-Schiff-base-silica framework as a robust and recyclable catalyst for Suzuki–Miyaura cross-coupling in aqueous media
Authors: Begum Tahshina , Mondal Manoj , Gogoi Pradip K. , Bora Utpal
Published: April 2015

A novel Pd@imine-SiO2 catalyst was prepared and found to exhibit excellent catalytic activity in a Suzuki-Miyaura cross-coupling reaction under aqueous media at room temperature.
Uncovering the antifungal components from turmeric (Curcuma longa L.) essential oil as Aspergillus flavus fumigants by partial least squares
Authors: Hu Yichen , Luo Jiaoyang , Kong Weijun , Zhang Jinming , Logrieco Antonio F. , Wang Xizhi , Yang Meihua
Published: April 2015

Three volatile compounds in turmeric essential oil that work as fumigants againstAspergillus flavushave been uncovered based on PLS modelling.
Water-dispersible and stable fluorescent Maya Blue-like pigments
Authors: Zhang Yujie , Fan Ling , Zhang Junping , Wang Aiqin
Published: April 2015

Water-dispersible and stable fluorescent Maya Blue-like pigments were prepared via the host–guest interaction between LAPONITE® RD and Pigment Red 31.
Matrix-isolation and computational study of the HKrCCH⋯HCCH complex
Authors: Willmann Knut , Vent-Schmidt Thomas , Räsänen Markku , Riedel Sebastian , Khriachtchev Leonid
Published: April 2015

The HKrCCH⋯HCCH complex is identified in a Kr matrix with the H–Kr stretching bands at 1316.5 and 1305 cm−1. The assignment is fully supported by extensive quantum chemical calculations.
Tunable Ag+ ion release from Ag@C for antibacterial and antifouling performances
Authors: Yan Xiaoliang , Li Sha , Pan Yunxiang , Xing Bin , Li Ruifeng , Jang Ben W.-L. , Liu Xuguang
Published: April 2015

A method for the controllable release of Ag+ ion was proposed by the synthesis of carbon-encapsulated Ag (Ag@C) for antibacterial and antifouling performances.
Spectra and energy levels of a layered Yb3+:CsGd(MoO4)2 crystal with perfect cleavage: a candidate for microchip lasers
Authors: Zhao Wang , Huang Yi-sheng , Lin Zhou-bin , Wei Bo , Wang Feng-wu , Xu Mai , Zhao Xing , Zheng Qing-hua , Zhou Wei-wei
Published: April 2015

The peculiar structure of the Yb3+:CsGd(MoO4)2 crystal leads to cleavage slices suitable for microchip lasers, large ground-level splitting and high transition cross-sections, while the gain bandwidth is broad enough to generate sub-100 fs laser pulses.
Silver salts of carboxylic acid terminated generation 1 poly (propyl ether imine) (PETIM) dendron and dendrimers as antimicrobial agents against S. aureus and MRSA
Authors: Suleman Nadia , Kalhapure Rahul S. , Mocktar Chunderika , Rambharose Sanjeev , Singh Moganavelli , Govender Thirumala
Published: April 2015

In this study the newly synthesised PETIM silver salts displayed a low toxicity level and showed significant antimicrobial activity against both sensitive (S. aureus) and resistant (MRSA) bacterial strains.
Coordination-resolved bonding and electronic dynamics of Na atomic clusters and solid skins
Authors: Bo Maolin , Guo Yongling , Huang Yongli , Liu Yonghui , Wang Yan , Li Can , Sun Chang Q.
Published: April 2015

Atomic undercoordination shortens the interatomic bond, deepens the energy level, raises the local energy density and lowers the atomic cohesive energy of Na solid skins and clusters.
Chemical modification of poly(vinyl chloride) for blood and cellular biocompatibility
Authors: Monika Monika , Mahto Sanjeev Kumar , Das Snehashish , Ranjan Amit , Singh Santosh Kumar , Roy Partho , Misra Nira
Published: April 2015

Poly(vinyl chloride) (PVC) was modified with three different ionomers including thiosulphate, thiourea and sulphite for improving the biocompatibility of the polymer.
Phase formation and stability of alloy phases in free nanoparticles: some insights
Authors: Malviya Kirtiman Deo , Srivastava Chandan , Chattopadhyay K.
Published: April 2015

This paper explores phase formation and phase stability in free nanoparticles of binary alloys.
Effect of porous zinc–biochar nanocomposites on Cr(vi) adsorption from aqueous solution
Authors: Gan Chao , Liu Yunguo , Tan Xiaofei , Wang Shufan , Zeng Guangming , Zheng Bohong , Li Tingting , Jiang Zhengjiang , Liu Wei
Published: April 2015

A new synthesis method was developed to produce zinc–biochar nanocomposites from sugarcane bagasse.
Using an “underwater superoleophobic pattern” to make a liquid lens array
Authors: Yong Jiale , Yang Qing , Chen Feng , Du Guangqing , Shan Chao , Farooq Umar , Wang Jiuhong , Hou Xun
Published: April 2015

A new strategy to realize a real liquid lens array without evaporation problems based on a femtosecond laser-induced underwater superoleophobic–oleophobic heterogeneous pattern.
One-pot synthesis of a TiO2–CdS nano-heterostructure assembly with enhanced photocatalytic activity
Authors: Mazumdar Sayantan , Bhattacharyya Aninda J.
Published: April 2015

An unprecedented morphology of a titanium dioxide (TiO2) and cadmium sulfide (CdS) self-assembly obtained using a ‘truly’ one-pot and highly cost effective method with a multi-gram scale yield is reported here.
Comparative study of normal, micro- & nano-sized iron oxide effect in potentiometric determination of fluconazole in biological fluids
Authors: Hussein Lobna A. , El-Kosasy Amira M. , Trabik Yossra A.
Published: April 2015

Three novel fluconazole (FLU) selective electrodes were investigated with di-octyl phthalate as a plasticizer in a polymeric matrix of polyvinyl chloride and 2-hydroxypropyl-β-cyclodextrin as an ionophore.
A novel polyoxometalate templated microporous metal–organic framework with electrochemical properties
Authors: Wang Xiuli , Chang Zhihan , Lin Hongyan , Xu Chuang , Luan Jian , Liu Guocheng , Tian Aixiang
Published: April 2015

A novel Wells–Dawson polyoxometalate-templated 3D microporous metal–organic framework with a rare 86 uniform net was obtained, which showed electrochemical properties.
Particle-size dependent melt viscosity behavior and the properties of three-arm star polystyrene–Fe3O4composites
Authors: Tan Haiying , Lin Yichao , Zheng Jun , Gong Jiang , Qiu Jian , Xing Haiping , Tang Tao
Published: April 2015

Compared to three-arm star polystyrene (S3PS), the melt viscosity of S3PS–Fe3O4composites reduces (white area) or increases (yellow area), which strongly depends on the arm molecular weight of S3PS (Ma), the radius of gyration of SPS (Rg) and the size of Fe3O4nanoparticles (Rp).
Bijels stabilized using rod-like particles
Authors: Hijnen Niek , Cai Dongyu , Clegg Paul S.
Published: April 2015

The effect of stabilizing bicontinuous interfacially jammed emulsion gels, in short ‘bijels’, using rod-like instead of spherical colloidal particles is investigated.
Synthesis of novel nitrogen-doped lithium titanate with ultra-high rate capability using melamine as a solid nitrogen source
Authors: Guo Min , Wang Suqing , Ding Liang-Xin , Zheng Long , Wang Haihui
Published: April 2015

A simple and environmentally friendly route for the synthesis of N-doped Li4Ti5O12 anodes with excellent rate capability and cycling stability.
Theoretical insight into the roles of cocatalysts in the Ni–NiO/β-Ga2O3photocatalyst for overall water splitting
Authors: Liu Taifeng , Tranca Ionut , Yang Jingxiu , Zhou Xin , Li Can
Published: April 2015

Ninand (NiO)nclusters located on different β-Ga2O3(100) surface sites participate in photocatalytic proton reduction and water oxidation reactions, respectively.
Porphyrin-functionalized mesoporous organosilica nanoparticles for two-photon imaging of cancer cells and drug delivery
Authors: Mauriello-Jimenez Chiara , Croissant Jonas , Maynadier Marie , Cattoën Xavier , Wong Chi Man Michel , Vergnaud Julien , Chaleix Vincent , Sol Vincent , Garcia Marcel , Gary-Bobo Magali , Raehm Laurence , Durand Jean-Olivier
Published: April 2015

The synthesis of porphyrin-functionalized ethylene-based mesoporous organosilica nanoparticles was performed.
Combinatorial targeting polymeric micelles for anti-tumor drug delivery
Authors: Yang Saina , Zhu Feiyan , Wang Qian , Liang Fuxin , Qu Xiaozhong , Gan Zhihua , Yang Zhenzhong
Published: April 2015

Polymeric micelles with combinatorial targeting ability for cancer cells was achieved by co-assembly of cRGD-PEO-b-PCL and tumor pHesensitive PEG-DOX.
Biodegradable PLGA nanoparticles loaded with hydrophobic drugs: confocal Raman microspectroscopic characterization
Authors: Yan Hu , Hou Yi-Fan , Niu Peng-Fei , Zhang Ke , Shoji Tatsuya , Tsuboi Yasuyuki , Yao Fang-Yao , Zhao Li-Min , Chang Jun-Biao
Published: April 2015

PLGA nanoparticles with bicyclol and Br-NBP were for the first time successfully characterized by a laser trapping/confocal Raman spectroscopic technique only using individual nanoparticles.
Impaired Statistical Learning in Developmental Dyslexia
Authors: Gabay Yafit , Thiessen Erik D. , Holt Lori L.
Published: April 2015

Purpose

Developmental dyslexia (DD) is commonly thought to arise from phonological impairments. However, an emerging perspective is that a more general procedural learning deficit, not specific to phonological processing, may underlie DD. The current study examined if individuals with DD are capable of extracting statistical regularities across sequences of passively experienced speech and nonspeech sounds. Such statistical learning is believed to be domain-general, to draw upon procedural learning systems, and to relate to language outcomes.

Method

DD and control groups were familiarized with a continuous stream of syllables or sine-wave tones, the ordering of which was defined by high or low transitional probabilities across adjacent stimulus pairs. Participants subsequently judged two 3-stimulus test items with either high or low statistical coherence as being the most similar to the sounds heard during familiarization.

Results

As with control participants, the DD group was sensitive to the transitional probability structure of the familiarization materials as evidenced by above-chance performance. However, the performance of participants with DD was significantly poorer than controls across linguistic and nonlinguistic stimuli. In addition, reading-related measures were significantly correlated with statistical learning performance of both speech and nonspeech material.

Conclusion

Results are discussed in light of procedural learning impairments among participants with DD.
Linguistic Feature Development Across Grades and Genre in Elementary Writing
Authors: Hall-Mills Shannon , Apel Kenn
Published: April 2015

Purpose

As children develop skills in writing across academic contexts, clinicians and educators need to have a fundamental understanding of typical writing development as well as valid and reliable assessment methods. The purpose of this study was to examine the progression of linguistic elements in school-age children's narrative and expository writing development.

Method

Narrative and expository writing samples produced by 89 children in Grades 2 through 4 were analyzed at the microstructure and macrostructure levels. Measures of receptive vocabulary, word-level reading, and reading comprehension were obtained.

Results

Exploratory factor analyses revealed 4 microstructure factors (e.g., productivity, grammatical complexity, grammatical accuracy, and lexical density) and 1 macrostructure factor (e.g., a combination of organization, text structure, and cohesion). Multivariate analyses of covariance with reading comprehension as a covariate showed that productivity and macrostructure were sensitive to grade-level and genre differences and that expository grammatical complexity was sensitive to grade-level differences.

Conclusions

Findings are discussed in light of grade-level standards for narrative and expository writing and current practices in writing assessment. Multiple suggestions are offered for clinical and educational implications, and specific directions are provided for future research.
State response for continuous‐time antilinear systems
Authors: Wu Ai‐Guo , Zhang Ying , Liu Wanquan , Sreeram Victor
Published: April 2015

In this study, the authors investigate the state response for continuous‐time antilinear dynamical systems. First, they propose the concept of matrix anti‐exponential function, and then derived some nice properties of this new function. With the matrix anti‐exponential function as an effective tool, they obtain a closed‐form expression for the state response of continuous‐time antilinear systems. Finally, they derived an expression with finite terms for the proposed matrix anti‐exponential function, which will be useful for numerical implementation.
Identifying latent dynamic components in biological systems
Authors: Kondofersky Ivan , Fuchs Christiane , Theis Fabian J.
Published: April 2015

In computational systems biology, the general aim is to derive regulatory models from multivariate readouts, thereby generating predictions for novel experiments. In the past, many such models have been formulated for different biological applications. The authors consider the scenario where a given model fails to predict a set of observations with acceptable accuracy and ask the question whether this is because of the model lacking important external regulations. Real‐world examples for such entities range from microRNAs to metabolic fluxes. To improve the prediction, they propose an algorithm to systematically extend the network by an additional latent dynamic variable which has an exogenous effect on the considered network. This variable's time course and influence on the other species is estimated in a two‐step procedure involving spline approximation, maximum‐likelihood estimation and model selection. Simulation studies show that such a hidden influence can successfully be inferred. The method is also applied to a signalling pathway model where they analyse real data and obtain promising results. Furthermore, the technique can be employed to detect incomplete network structures.
Deterministic inference for stochastic systems using multiple shooting and a linear noise approximation for the transition probabilities
Authors: Zimmer Christoph , Sahle Sven
Published: April 2015

Estimating model parameters from experimental data is a crucial technique for working with computational models in systems biology. Since stochastic models are increasingly important, parameter estimation methods for stochastic modelling are also of increasing interest. This study presents an extension to the ‘multiple shooting for stochastic systems (MSS)’ method for parameter estimation. The transition probabilities of the likelihood function are approximated with normal distributions. Means and variances are calculated with a linear noise approximation on the interval between succeeding measurements. The fact that the system is only approximated on intervals which are short in comparison with the total observation horizon allows to deal with effects of the intrinsic stochasticity. The study presents scenarios in which the extension is essential for successfully estimating the parameters and scenarios in which the extension is of modest benefit. Furthermore, it compares the estimation results with reversible jump techniques showing that the approximation does not lead to a loss of accuracy. Since the method is not based on stochastic simulations or approximative sampling of distributions, its computational speed is comparable with conventional least‐squares parameter estimation methods.
Use of seismic attributes for sediment classification
Authors: Radomille Santana Fabio , Ayres Neto Arthur
Published: April 2015

A study to understand the relationships between seismic attributes extracted from 2D high‐resolution seismic data and the seafloor's sediments of the surveyed area. As seismic attributes are features highly influenced by the medium through which the seismic waves are propagated, the authors can assume that it would be possible to characterise the geological nature of the seafloor by using these attributes. Herein, a survey was performed on the continental margin of the South Shetland Islands in Antarctica, where both 2D high‐resolution seismic data and sediment gravity cores samples were simultaneously acquired. A computational script was written to extract the seismic attributes from the data, which have been statistically analysed with clustering analyses, such as principal components analysis, dendrograms and k‐means classification. The extracted seismic attributes are the amplitude, the instantaneous phase, the instantaneous frequency, the envelope, the time derivative of the envelope, the second derivative of the envelope and the acceleration of phase. Statistical evaluation showed that geological classification of the seafloor's sediments is possible by associating these attributes according to their coherence. The methodologies here developed seem to be appropriate for glacio‐marine environment and coarse‐to‐medium silt sediment found in the study area and may be applied to other regions in the same geological conditions.
The future of transgenic farm animal production with emphasis on pigs.
Authors: Petersen B. , Niemann H.
Published: April 2015

Transgenic livestock already play an important role as models for human diseases, for producing recombinant pharmaceutical proteins, and in the future may serve as donors of organs for terminally ill patients and tissues and cells in regenerative medicine to cope with degenerative diseases and ultimately might contribute to satisfy the increasing demand for valuable animal derived proteins for an ever-increasing global human population. The first transgenic livestock were produced in 1985 by microinjection of foreign DNA into zygotic pronuclei. Since then, significant progress has been made with regard to methods that permit efficient and targeted insertion of precise modifications in the complex mammalian genomes. This in turn will further enhance the development of transgenic livestock with well-defined genetically engineered chromosomal loci that are not affected by neighbouring chromosomal sequences and without integration of undesired DNA sequences such as antibiotic resistant cassettes that hinder products of these animals to enter the market. Here, we review the recent advances of the methodologies for the production of transgenic farm animals which will be important in meeting global challenges in valuable animal protein production and will open new horizons for biomedicine.
Prediction of nitrogen efficiency in dairy cattle: a review.
Authors: Reed K. F. , Casper D. P. , France J. , Kebreab E.
Published: April 2015

Increasing the efficiency of conversion of feed nitrogen (N) into milk and meat N in dairy cattle is an integral part of the effort to maintain or increase food production while decreasing agriculture's environmental impact. Mathematical models provide a means to assess and compare different strategies to increase N efficiency; however, their merit depends on the models' predictive capabilities. Evaluation of the currently available empirical models to predict faecal and urinary N excretion revealed low prediction accuracy and the presence of significant systematic biases. Application of more diverse and advanced model development techniques are needed to produce models whose precision and accuracy are sufficient for application in emissions mitigation protocols. Mechanistic models continue to advance and push the boundaries of knowledge in ruminant N metabolism; aided by advances in computer technology. However, improvement is required in the description of factors that influence microbial protein production and the use of metabolizable protein; this represents the greatest potential for increasing our prediction and understanding of N efficiency in dairy cattle. Attention to these two aspects of ruminant N metabolism in mechanistic models directed specifically at improving N efficiency and in the widely used nutrient requirement models will enhance our ability to meet dairy cattle's protein requirements in a sustainable manner.
Two-Body Scattering in (1 + 1) Dimensions by a Semi-relativistic Formalism and a Hulthén Interaction Potential
Authors: Hassanabadi S. , Ghominejad M. , Thylwe K.-E.
Published: April 2015

Scattering solutions of two-body Spinless Salpeter Equation (SSE) are investigated in the center of mass frame with a repulsive, symmetric Hulthén potential in one spatial dimension. Transmission and reflection coefficients are calculated and discussed.
Dynamic (2, 3) Threshold Quantum Secret Sharing of Secure Direct Communication*
Authors: Lai Hong , Mehmet Orgun A. , Xiao Jing-Hua , Josef Pieprzyk , Xue Li-Yin
Published: April 2015

In this paper, we show that a (2, 3) discrete variable threshold quantum secret sharing scheme of secure direct communication can be achieved based on recurrence using the same devices as in BB84. The scheme is devised by first placing the shares of smaller secret pieces into the shares of the largest secret piece, converting the shares of the largest secret piece into corresponding quantum state sequences, inserting nonorthogonal state particles into the quantum state sequences with the purpose of detecting eavesdropping, and finally sending the new quantum state sequences to the three participants respectively. Consequently, every particle can on average carry up to 1.5-bit messages due to the use of recurrence. The control codes are randomly prepared using the way to generate fountain codes with pre-shared source codes between Alice and Bob, making three participants can detect eavesdropping by themselves without sending classical messages to Alice. Due to the flexible encoding, our scheme is also dynamic, which means that it allows the participants to join and leave freely.
GS-align for glycan structure alignment and similarity measurement
Authors: Lee Hui Sun , Jo Sunhwan , Mukherjee Srayanta , Park Sang-Jun , Skolnick Jeffrey , Lee Jooyoung , Im Wonpil
Published: April 2015

Motivation: Glycans play critical roles in many biological processes, and their structural diversity is key for specific protein-glycan recognition. Comparative structural studies of biological molecules provide useful insight into their biological relationships. However, most computational tools are designed for protein structure, and despite their importance, there is no currently available tool for comparing glycan structures in a sequence order- and size-independent manner.

Results: A novel method, GS-align, is developed for glycan structure alignment and similarity measurement. GS-align generates possible alignments between two glycan structures through iterative maximum clique search and fragment superposition. The optimal alignment is then determined by the maximum structural similarity score, GS-score, which is size-independent. Benchmark tests against the Protein Data Bank (PDB) N-linked glycan library and PDB homologous/non-homologous N-glycoprotein sets indicate that GS-align is a robust computational tool to align glycan structures and quantify their structural similarity. GS-align is also applied to template-based glycan structure prediction and monosaccharide substitution matrix generation to illustrate its utility.

Availability and implementation:  http://www.glycanstructure.org/gsalign.

Contact:  wonpil@ku.edu

Supplementary information:  Supplementary data are available at Bioinformatics online.
Recombination energy in double white dwarf formation
Authors: Nandez J. L. A. , Ivanova N. , Lombardi J. C.
Published: April 2015

In this Letter, we investigate the role of recombination energy during a common envelope event. We confirm that taking this energy into account helps to avoid the formation of the circumbinary envelope commonly found in previous studies. For the first time, we can model a complete common envelope event, with a clean compact double white dwarf binary system formed at the end. The resulting binary orbit is almost perfectly circular. In addition to considering recombination energy, we also show that between 1/4 and 1/2 of the released orbital energy is taken away by the ejected material. We apply this new method to the case of the double white dwarf system WD 1101+364, and we find that the progenitor system at the start of the common envelope event consisted of an ∼1.5 M⊙ red giant star in an ∼30 d orbit with a white dwarf companion.
Preexisting Cognitive Impairment Is Associated with Postoperative Cognitive Dysfunction after Hip Joint Replacement Surgery
Authors: Silbert Brendan , Evered Lisbeth , Scott David A. , McMahon Stephen , Choong Peter , Ames David , Maruff Paul , Jamrozik Konrad
Published: April 2015

AbstractAbstract

Preexisting cognitive dysfunction was identified in approximately a third of the patients before surgery. Preexisting cognitive dysfunction is a good predictor of cognitive dysfunction 1 yr after surgery. However, there is no evidence that anesthesia and surgery per se contribute to cognitive dysfunction 1 yr after surgery.

Background:

This study investigated the prevalence of cognitive impairment in elderly noncardiac surgery patients and any association between preoperative cognitive impairment and postoperative cognitive dysfunction (POCD). Additionally, the incidence of cognitive decline at 12 months after surgery was identified.

Methods:

Three hundred patients for hip joint replacement and 51 nonsurgical controls aged 60 yr or older were studied in a prospective observational clinical trial. All study participants and controls completed a battery of eight neuropsychological tests before surgery and at 7 days, 3 months, and 12 months afterwards. Preoperative cognitive status was assessed using preexisting cognitive impairment (PreCI) defined as a decline of at least 2 SD on two or more of seven neuropsychological tests compared to population norms. POCD and cognitive decline were assessed using the reliable change index utilizing the results of the control group.

Results:

PreCI was classified in 96 of 300 (32%) patients (95% CI, 23 to 43%). After surgery, 49 of 286 (17%) patients (95% CI, 13 to 22%) and 27 of 284 (10%) patients (95% CI, 6 to 13%) demonstrated POCD at 7 days and 3 months, respectively, while 7 of 271 (3%) patients (95% CI, 1 to 4%) demonstrated cognitive decline at 12 months. Patients with PreCI had a significantly increased incidence of POCD at 7 days and 3 months and cognitive decline at 12 months.

Conclusions:

Patients with PreCI have an increased incidence of POCD and cognitive decline. PreCI is a good predictor of subsequent POCD and cognitive decline. The incidence of cognitive decline after 12 months in this group of patients is low.
Acetaminophen Adducts Detected in Serum of Pediatric Patients With Acute Liver Failure
Authors: Alonso Estella M. , James Laura P. , Zhang Song , Squires Robert H. ,   Pediatric Acute Liver Failure Study Group
Published: April 2015

Objectives:

Previous studies in patients with acute liver failure identified acetaminophen (APAP) protein adducts in the serum of 12% and 19% of children and adults, respectively, with acute liver failure of indeterminate etiology. This article details the testing of APAP adducts in a subset (n = 393) of patients with varied diagnoses in the Pediatric Acute Liver Failure Study Group (PALFSG).

Methods:

Serum samples were available from 393 participants included in the PALFSG registry. Adduct measurement was performed using validated methods. Participants were grouped by diagnostic category as known APAP overdose, known other diagnosis, and indeterminate etiology. Demographic and clinical characteristics and participant outcomes were compared by adduct status (positive or negative) within each group.

Results:

APAP adduct testing was positive in 86% of participants with known APAP overdose, 6% with other known diagnoses, and 11% with an indeterminate cause of liver failure. Adduct‐positive participants were noted to have marked elevation of serum alanine aminotransferase and aspartate aminotransferase coupled with total serum bilirubin that was significantly lower than adduct‐negative patients. In the indeterminate group, adduct‐positive patients had different outcomes than adduct‐negative patients (P = 0.03); spontaneous survival was 16 of 21 (76%) in adduct‐positive patients versus 75 of 169 (44%) in adduct‐negative patients. Prognosis did not vary by adduct status in patients with known diagnoses.

Conclusions:

Furthermore, study is needed to understand the relation of APAP exposure, as determined by the presence of APAP adducts, to the clinical phenotype and outcomes of children with acute liver failure.
Elizabethkingia endophytica sp. nov., isolated from Zea mays and emended description of Elizabethkingia anophelis

Kämpfer et al. 2011
Authors: Kämpfer Peter , Busse Hans-Jürgen , McInroy John A. , Glaeser Stefanie P.
Published: April 2015

A slightly yellow bacterial strain (JM-87T), isolated from the stem of healthy 10 day-old sweet corn (Zea mays), was studied for its taxonomic allocation. The isolate revealed Gram-stain-negative, rod-shaped cells. A comparison of the 16S rRNA gene sequence of the isolate showed 99.1, 97.8, and 97.4 % similarity to the 16S rRNA gene sequences of the type strains of Elizabethkingia anophelis, Elizabethkingia meningoseptica and Elizabethkingia miricola, respectively. The fatty acid profile of strain JM-87T consisted mainly of the major fatty acids C15:0 iso, C17:0 iso 3-OH, and C15:0 iso 2-OH/C16:1ω7c/t. The quinone system of strain JM-87T contained, exclusively, menaquinone MK-6. The major polyamine was sym-homospermidine. The polar lipid profile consisted of the major lipid phosphatidylethanolamine plus several unidentified aminolipids and other unidentified lipids. DNA–DNA hybridization experiments with E. meningoseptica CCUG 214T ( = ATCC 13253T), E. miricola KCTC 12492T ( = GTC 862T) and E. anophelis R26T resulted in relatedness values of 17 % (reciprocal 16 %), 30 % (reciprocal 19 %), and 51 % (reciprocal 54 %), respectively. These DNA–DNA hybridization results, in addition to some differentiating biochemical properties, clearly indicate that strain JM-87T is a representative of a novel species, for which the name Elizabethkingia endophytica sp. nov. is proposed. The type strain is JM-87T ( = CIP 110885T = LMG 28604T = CCM 8570T).
Chryseobacterium arachidiradicis sp. nov., isolated from the geocarposphere (soil around the peanut) of very immature peanuts (Arachis hypogaea)
Authors: Kämpfer Peter , Busse Hans-Jürgen , McInroy John A. , Glaeser Stefanie P.
Published: April 2015

A yellow-pigmented bacterial strain, 91A-612T, isolated from the geocarposphere (soil around the peanut) of very immature peanuts (Arachis hypogaea) in Alabama, USA, was studied for its taxonomic position. Cells of the isolate were rod-shaped and stained Gram-negative. A comparison of the 16S rRNA gene sequence with the sequences of the type strains of the most closely related species showed that the strain belongs to the genus Chryseobacterium, showing the highest sequence similarities to the type strains of Chryseobacterium molle (98.4 %), C. pallidum (98.3 %) and C. hominis (97.8 %). The 16S rRNA gene sequence similarities to the type strains of all other species of the genus Chryseobacterium were below 97.0 %. The fatty acid profile of strain 91A-612T consisted of the major fatty acids iso-C15 : 0, summed feature 3 (iso-C15 : 0 2-OH/C16 : 1ω7c) and iso-C17 : 0 3-OH. Major compounds in the polar lipid profile were phosphatidylethanolamine and several unidentified lipids, including two lipids that did not contain a sugar moiety, an amino group or a phosphate group (L3, L8), and an aminolipid (AL1). The quinone system was composed mainly of MK-6. The polyamine pattern contained sym-homospermidine as the major compound and moderate amounts of spermidine and spermine. DNA–DNA hybridizations between strain 91A-612T and the type strains of C. molle, C. pallidum and C. hominis resulted in relatedness values well below 70 %. These data and the differentiating biochemical and chemotaxonomic properties showed that isolate 91A-612T represents a novel species of the genus Chryseobacterium, for which we propose the name Chryseobacterium arachidiradicis sp. nov. (type strain 91A-612T = LMG 27814T = CCM 8490T = CIP 110647T).