bluuebunny/crossref_metadata_2025 huggingface dataset:
Research on correlation of compositions with oestrogenic activity of Cistanche based on LC/Q-TOF-MS/MS technology
Authors: Li Wen-Lan , Ding Jing-Xin , Bai Jing , Hu Yang , Song Hui , Sun Xiang-Ming , Ji Yu-Bin
Published: January 2019

LC technology is a recognized method used worldwide to evaluate the quality of traditional Chinese medicines (TCM). The quality of TCM has a direct impact on its efficacy. Therefore, in order to thoroughly reveal how TCM exerts its efficacy, first of all, it is necessary to understand the material basis for its efficacy, and then to control the quality of active compounds. The application of the spectrum-effect relationship method is crucial for determining the pharmacological material basis. The goal of this paper was to investigate the underlying correlations between the chemical profiles and oestrogenic activity of Cistanche, to reveal the active compounds. The chemical profiles of Cistanche were recorded using HPLC/Q-TOF-MS/MS, and oestrogenic activity was determined by the Uterus growth test and the MTT assay. Then combining the results of bivariate analysis, principal component analysis and gray correlation analysis method, fifteen active compounds were identified. They are 8-epiloganic acid, salidroside, syringalide A 3’-α-l-rhamnopyranoside, cistanoside A, echinacoside, cistanoside F, cistanoside B, cistanoside C, osmanthuside B, acteoside, isoacteoside, tubuloside B, 2’-acetylacteoside, and two unknown compounds. This study lays a foundation for in vivo studies of Cistanche and for the development of its clinical application.
Effect of l-carnitine on aspartame-induced oxidative stress, histopathological changes, and genotoxicity in liver of male rats
Authors: Hamza Reham Z. , Al-Eisa Rasha A. , Mehana Amir E. , El-Shenawy Nahla S.
Published: January 2019

Background

Aspartame (ASP) is used for treatment of obesity and diabetes mellitus. This study was designed to illustrate the biochemical responses and histopathological alterations besides the genotoxicity of ASP alone or with l-carnitine (LC) in the liver of rats.

Methods

Animals were separated into six groups: control, lower dose of ASP (ASP-LD; 75 mg/kg), higher dose of ASP (ASP-HD; 150 mg/kg), l-carnitine (LC; 10 mg/kg), ASP-LD plus LC, and ASP-HD plus LC. Treatment was carried out orally for 30 consecutive days.

Results

ASP raised the activity of some enzymes of liver markers and disturbed the lipid profile levels. The hepatic reduced glutathione (GSH) levels, the marker enzymes of antioxidant activities, were obviously diminished, and, possibly, the lipid peroxidation, C-reactive protein, and interleukins levels were increased. ASP significantly increased the DNA deterioration in comparison with the control in a dose-dependent manner. LC prevented ASP-induced liver damage as demonstrated by the enhancement of all the above parameters. Results of histopathological and electron microscopic examination proved the biochemical feedback and the improved LC effect on liver toxicity.

Conclusions

The co-treatment of LC showed different improvement mechanisms against ASP-induced liver impairment. So, the intake of ASP should be regulated and taken with LC when it is consumed in different foods or drinks to decrease its oxidative stress, histopathology, and genotoxicity of liver.
In Search of Prester John and the ‘River of Gold’. Mecià de Viladestes’ Map and Late Medieval Knowledge about Africa
Authors: Brunnlechner Gerda
Published: January 2019

Mecià de Viladestes’ nautical map provides many-faceted incentives to travel down the African west coast, emphasising especially Africa’s riches in gold and the presence of a Christian ruler known as Prester John. Understanding maps not as a conclusive result of the collection of knowledge but as a means of communication, this article aims to explore the relations between contemporary Latin European conceptions about Africa, its representations on maps and their probable argumentative objectives. From Latin-African contacts the idea had arisen to form an alliance to fight the Muslims, attacking from two directions. The representation of sub-Saharan Africa on Mecià’s map can be interpreted as taking up this discussion to argue for further exploration of Africa down its Atlantic coast, which might have influenced future decision makers such as Henry the Navigator.
Mapping Continents, Inhabited Quarters and The Four Seas. Divisions of the World and the Ordering of Spaces in Latin-Christian, Arabic-Islamic and Chinese Cartography in the Twelfth to Sixteenth Centuries. A Critical Survey and Analysis
Authors: Mauntel Christoph , Oschema Klaus , Ducène Jean-Charles , Hofmann Martin
Published: January 2019

This paper explores the presence and development of large-scale geographic categories in pre-modern cartography (twelfth to sixteenth centuries) in a combination of comparative and transcultural perspectives. Analysing Latin-Christian, Arabic-Islamic and Chinese maps, we demonstrate the varying degrees of importance accorded to large-scale geographic structures. The choice of related as well as independent traditions allows for the identification of specific emphases which reflect the influence of the respective cultural backgrounds and strategies applied in the ordering of space. While the analysed Chinese material concentrates on a geographical space that was perceived to form an ideal political and cultural unity without representing the entire physical world, Latin-Christian and Arabic-Islamic traditions share the focus on the whole “oecumene” that they both inherited from antique models. However, only Latin-Christian maps consistently and explicitly present a tripartite world that resonates with Trinitarian structures in Christian thought.
Sexually Dimorphic Vasopressin Cells Modulate Social Investigation and Communication in Sex-Specific Ways
Authors: Rigney Nicole , Whylings Jack , Mieda Michihiro , de Vries Geert J. , Petrulis Aras
Published: January 2019

The neuropeptide arginine vasopressin (AVP) has long been implicated in the regulation of social behavior and communication, but precisely which AVP cell groups are involved is largely unknown. To address whether the sexually dimorphic AVP cell group in the bed nucleus of the stria terminalis (BNST) is important for social communication, we deleted BNST AVP cells by viral delivery of a Cre-dependent caspase-3 cell-death construct in AVP-iCre-positive mice using AVP-iCre negative littermate as controls, and assessed social, sexual, aggressive and anxiety-related behaviors. In males, lesioning BNST AVP cells reduced social investigation of other males and increased urine marking (UM) in the presence of a live female, without altering ultrasonic vocalizations (USVs), resident-intruder aggression, copulatory behavior, anxiety, or investigation of females or their odor cues. In females, which have significantly fewer AVP cells in the BNST, these injections influenced copulatory behavior but otherwise had minimal effects on social behavior and communication, indicating that these cells contribute to sex differences in social behavioral function.
Neurons in FEF Keep Track of Items That Have Been Previously Fixated in Free Viewing Visual Search
Authors: Mirpour Koorosh , Bolandnazar Zeinab , Bisley James W.
Published: January 2019

When searching a visual scene for a target, we tend not to look at items or locations we have already searched. It is thought that this behavior is driven by an inhibitory tagging mechanism that inhibits responses on priority maps to the relevant items. We hypothesized that this inhibitory tagging signal should be represented as an elevated response in neurons that keep track of stimuli that have been fixated. We recorded from 231 neurons in the frontal eye field (FEF) of 2 male animals performing a visual foraging task, in which they had to find a reward linked to one of five identical targets (Ts) among five distractors. We identified 38 neurons with activity that was significantly greater when the stimulus in the receptive field had been fixated previously in the trial than when it had not been fixated. The response to a fixated object began before the saccade ended, suggesting that this information is remapped. Unlike most FEF neurons, the activity in these cells was not suppressed during active fixation, had minimal motor responses, and did not change through the trial. Yet using traditional classifications from a memory-guided saccade, they were indistinguishable from the rest of the FEF population. We propose that these neurons keep track of any items that have been fixated within the trial and this signal is propagated by remapping. These neurons could be the source of the inhibitory tagging signal to parietal cortex, where a neuronal instantiation of inhibitory tagging is seen.

SIGNIFICANCE STATEMENTWhen we search a scene for an item, we rarely examine the same location twice. It is thought that this is due to a neural mechanism that keeps track of the items at which we have looked. Here we identified a subset of neurons in the frontal eye field that preferentially responded to items that had been fixated earlier in the trial. These responses were remapped, appearing before the saccade even ended, and were not suppressed during maintained fixation. We propose that these neurons keep track of which items have been examined in search and could be the source of feedback that creates the inhibitory tagging seen in parietal cortex.
Complement Targets Newborn Retinal Ganglion Cells for Phagocytic Elimination by Microglia
Authors: Anderson Sarah R. , Zhang Jianmin , Steele Michael R. , Romero Cesar O. , Kautzman Amanda G. , Schafer Dorothy P. , Vetter Monica L.
Published: January 2019

Microglia play important roles in shaping the developing CNS, and at early stages they have been proposed to regulate progenitor proliferation, differentiation, and neuronal survival. However, these studies reveal contradictory outcomes, highlighting the complexity of these cell–cell interactions. Here, we investigate microglia function during embryonic mouse retina development, where only microglia, progenitors, and neurons are present. In both sexes, we determine that microglia primarily interact with retinal neurons and find that depletion of microglia via conditional KO of theCsf1receptor results in increased density of retinal ganglion cells (RGCs). Pharmacological inhibition of microglia also results in an increase in RGCs, with no effect on retinal progenitor proliferation, RGC genesis, or apoptosis. We show that microglia in the embryonic retina are enriched for phagocytic markers and observe engulfment of nonapoptotic Brn3-labeled RGCs. We investigate the molecular pathways that can mediate cell engulfment by microglia and find selective downregulation of complement pathway components with microglia inhibition, and further show that C1q protein marks a subset of RGCs in the embryonic retina. KO of complement receptor 3 (CR3; Itgam), which is only expressed by microglia, results in increased RGC density, similar to what we observed after depletion or inhibition of microglia. Thus, our data suggest that microglia regulate neuron elimination in the embryonic mouse retina by complement-mediated phagocytosis of non-apoptotic newborn RGCs.

SIGNIFICANCE STATEMENTMicroglia are emerging as active and important participants in regulating neuron number in development, during adult neurogenesis, and following stem cell therapies. However, their role in these contexts and the mechanisms involved are not fully defined. Using a well-characterizedin vivosystem, we provide evidence that microglia regulate neuronal elimination by complement-mediated engulfment of nonapoptotic neurons. This work provides a significant advancement of the field by definingin vivomolecular mechanisms for microglia-mediated cell elimination. Our data add to a growing body of evidence that microglia are essential for proper nervous system development. In addition, we elucidate microglia function in the developing retina, which may shed light on microglia involvement in the context of retinal injury and disease.
The diagnosis and management of central hypothyroidism in 2018
Authors: Persani Luca , Cangiano Biagio , Bonomi Marco
Published: January 2019

Central hypothyrodism (CeH) is a hypothyroid state caused by an insufficient stimulation by thyrotropin (TSH) of an otherwise normal thyroid gland. Several advancements, including the recent publication of expert guidelines for CeH diagnosis and management, have been made in recent years thus increasing the clinical awareness on this condition. Here, we reviewed the recent advancements and give expert opinions on critical issues. Indeed, CeH can be the consequence of various disorders affecting either the pituitary gland or the hypothalamus. Recent data enlarged the list of candidate genes for heritable CeH and a genetic origin may be the underlying cause for CeH discovered in pediatric or even adult patients without apparent pituitary lesions. This raises the doubt that the frequency of CeH may be underestimated. CeH is most frequently diagnosed as a consequence of the biochemical assessments in patients with hypothalamic/pituitary lesions. In contrast with primary hypothyroidism, low FT4 with low/normal TSH levels are the biochemical hallmark of CeH, and adequate thyroid hormone replacement leads to the suppression of residual TSH secretion. Thus, CeH often represents a clinical challenge because physicians cannot rely on the use of the ‘reflex TSH strategy’ for screening or therapy monitoring. Nevertheless, in contrast with general assumption, the finding of normal TSH levels may indicate thyroxine under-replacement in CeH patients. The clinical management of CeH is further complicated by the combination with multiple pituitary deficiencies, as the introduction of sex steroids or GH replacements may uncover latent forms of CeH or increase the thyroxine requirements.
Iso-Seq Allows Genome-Independent Transcriptome Profiling of Grape Berry Development
Authors: Minio Andrea , Massonnet Mélanie , Figueroa-Balderas Rosa , Vondras Amanda M , Blanco-Ulate Barbara , Cantu Dario
Published: January 2019

Transcriptomics has been widely applied to study grape berry development. With few exceptions, transcriptomic studies in grape are performed using the available genome sequence, PN40024, as reference. However, differences in gene content among grape accessions, which contribute to phenotypic differences among cultivars, suggest that a single reference genome does not represent the species’ entire gene space. Though whole genome assembly and annotation can reveal the relatively unique or “private” gene space of any particular cultivar, transcriptome reconstruction is a more rapid, less costly, and less computationally intensive strategy to accomplish the same goal. In this study, we used single molecule-real time sequencing (SMRT) to sequence full-length cDNA (Iso-Seq) and reconstruct the transcriptome of Cabernet Sauvignon berries during berry ripening. In addition, short reads from ripening berries were used to error-correct low-expression isoforms and to profile isoform expression. By comparing the annotated gene space of Cabernet Sauvignon to other grape cultivars, we demonstrate that the transcriptome reference built with Iso-Seq data represents most of the expressed genes in the grape berries and includes 1,501 cultivar-specific genes. Iso-Seq produced transcriptome profiles similar to those obtained after mapping on a complete genome reference. Together, these results justify the application of Iso-Seq to identify cultivar-specific genes and build a comprehensive reference for transcriptional profiling that circumvents the necessity of a genome reference with its associated costs and computational weight.
A COMPARATIVE STUDY OF THE ACCURACY OF FIVE CAD-CAM SYSTEMS
Authors: Buduru Smaranda , Culic Bogdan , Talmaceanu Daniel , Pal Adorjan
Published: January 2019

Background and aims. The study aims at comparing the precision of different CAD/CAM systems: original systems built by the same manufacturer as opposed to systems whose components are built by different manufacturers.Methods. We used the same physical cast which was scanned with five different scanners. The design of the PMMA copings was done by the same operator for the five virtual casts. Each coping was milled three times by each milling machine, thus obtaining 75 copings. The internal space was analyzed by scanning the replicas in light body silicone.Results. The results analyzed the vertical marginal space (VMS) at the preparation limit, the axial internal space (AIS) and the internal occlusal space (IOS). For VMS the best results were obtained for scanner no 5 (S5) and milling machine 3 (M3). For AIS the best results were obtained with S4 and M3 combination. For IOS the best results were obtained with S45 and M3 combination.Conclusions. According to the results of the study, we are able to confirm the working hypothesis by stating the following conclusions: the quality of the prosthetic elements obtained through CAD/CAM processing differs depending on the CAD/CAM system used and is influenced by each component of every system individually, both the scanner and the milling unit; changing/switching any component of the CAD/CAM system has an impact on the quality of the resulting prosthetic work, but in an unpredictable manner.
Computational Practices, Educational Theories, and Learning Development
Authors: Passey Don , Dagienė Valentina , Atieno Loice Victorine , Baumann Wilfried
Published: January 2019

[full article, abstract in English; abstract in Lithuanian]

Many countries are adopting computing (or informatics) in schools, for pupils from 5 years of age. Educational philosophies (and learning theories) that such curricula might be based on are not clear in curriculum documentation. Many Western countries’ curricula are based on developmental concepts of cognitive constructivism, with activities progressing through sensorimotor, preoperational, concrete operational, and formal operational stages. Social constructivism and constructionism add new dimensions to this learning framework, both fundamentally important for developing computing practices. We review selected learning theories, and investigate features that should underpin computing curricula if practices and outcomes are to develop computing practitioner competencies of a software developer.
Kaip galimas neklystamas žinojimas apie atsitiktinę ateitį?
Authors: Pabijutaitė Živilė
Published: January 2019

[tekstas lietuvių kalba]
¡Odio esta vida, me suicido!
Authors: De la Pava Ossa Arturo
Published: January 2019

El paso al acto suicida apareció como cortejo frecuente en la tradiciónliteraria del Romanticismo, donde la aniquilación propia resultó ser la expresión de la pasión de un odio por la vida fundado en la frustración de la aspiración amorosa y la imposibilidad de gozar del objeto amado. A partir de un estudio de caso de la novela Los sufrimientos del joven Werther, el autor explora las posibilidades existenciales del héroe romántico que, al no ser correspondido por la amada, termina dándose muerte; una salida que terminó siendo imitada por muchos lectores de la novela de Goethe en Francia.
¿Por qué tanto odio? (reseña)
Authors: Cotrino Nieto Myriam Esther Cotrino Nieto
Published: January 2019

Reseña libro: Roudinesco, Élisabeth. ¿Por qué tanto odio? Buenos Aires: Libros del Zorzal, 2011. 125 páginas.
Análise do potencial empreendedor em alunos do ensino superior: aplicacao da teoria à prática
Authors: Fernandes Pietrovski Eliane , Schneider Elton Ivan , Reis Dálcio Roberto , Dos Reis Junior Dálcio Roberto
Published: January 2019

A universidade tem como uma de suas funções transformar a realidade social por meio de seus cursos. O empreendedor é visto como um agente de transformação econômica e social, pois seu campo de atuação implica considerar aspectos como inovação, criatividade, resolução de problemas, criação de empregos, invenção, liderança, cultura, entre outros. Esta pesquisa tem como objetivo analisar o potencial empreendedor de alunos do ensino superior fazendo uma investigação para responder à questão problema que norteia o presente trabalho, se as atividades de ensino e aprendizagem dirigidas para a aprendizagem experiencial, combinadas com técnicas de design thinking, podem aumentar o potencial empreendedor dos alunos dos cursos de graduação. Como resultados, a pesquisa apontou que os alunos ingressantes no ensino superior apresentam lacunas de formação em seu potencial empreendedor e que cabe às universidades criar processos de ensino e aprendizagem que preencham esses espaços.
Programas gubernamentales para la internacionalización de las empresas: una reflexión desde el caso del sector de cosméticos y productos de aseo en Bogotá
Authors: Diaz-Ariza Diana Marcela , García-Castiblanco Claudia Paola , Pinzón Muñoz Carlos Andrés
Published: January 2019

Para las empresas es cada vez más importante acceder a los mercados internacionales, a fin de expandirse y hacerse más competitivas. El uso de estrategias verdes en la organización ha sido planteado como un diferenciador del producto que le permitirá a la empresa ingresar más rápidamente a mercados extranjeros, en particular norteamericanos y europeos. Dados los dos programas del Gobierno colombiano que van orientados tanto al fortalecimiento empresarial —Programa de Transformación Productiva (PTP)— como a la implementación de estrategias verdes en las firmas —Plan Nacional de Negocios Verdes (PNNV)—, el objetivo de este trabajo es dar cuenta de las percepciones de los empresarios de un sector particular sobre el desarrollo de dichos programas, y reflexionar sobre la importancia que tiene el uso de las estrategias verdes en la internacionalización de las empresas, de manera específica para el sector de cosméticos y productos de aseo en Bogotá.
La influencia del capital intelectual en el desempeño de las pequeñas y medianas empresas manufactureras de México: el caso de Baja California.
Authors: Ibarra-Cisneros Manuel Alejandro , Hernández-Perlines Felipe
Published: January 2019

El satisfactorio desempeño de las organizaciones puede deberse a varios factores, entrelos que se encuentra el capital intelectual, que ha cobrado especial relevancia debido a que los bienes intangibles generan más valor que incluso los tangibles. La literatura al respecto señala que el incremento del valor en las pequeñas y medianas empresas recae en gran medida en el mantenimiento de un capital intelectual próspero y en constante evolución. El presente artículo tiene como objetivo establecer la influencia del capital intelectual en el desempeño de las pequeñas y medianas empresas del sector manufacturero de la región mexicana de Baja California. Para ello, se diseñó un cuestionario aplicado a 149 empresas de la región. Los resultados obtenidos recibieron un tratamiento estadístico basado primeramente en un análisis factorial de tipo exploratorio,seguido de uno confirmatorio; posteriormente, mediante el uso de regresiones lineales, se pudo dar comprobación a las hipótesis planteadas en el estudio. Los resultados mostraron que efectivamente existe una fuerte influencia del capital intelectual sobre el desempeño de las organizaciones. Asimismo, de manera específica se demostró que el capital organizativo es el que mayor influencia presenta en relación con el capital social y del cliente; en contraste, el capital tecnológico y humano no presentaron asociación alguna con el desempeño de las organizaciones. Los resultados permiten detectar áreas de oportunidad e implementar estrategias que revaloricen sus intangibles y, con ello, generen mayor valor para sus organizaciones.
Risco de Falência de PME: Evidência no setor da construção em Portugal
Authors: Pacheco Luís , Rosa Raquel , Oliveria Tavares Fernando
Published: January 2019

O presente artigo tem como objetivo encontrar as variáveis financeiras e não financeiras estatisticamente relevantes para a previsão de falência das empresas do setor da construção civil. Os modelos logit e probit previsionais de falência tornaram-se instrumentos úteis e eficazes na verificação das variáveis financeiras que sinalizam maiores perigos e antecipam situações críticas nas empresas. Verifica-se que os rácios que demonstram maior poder de previsão são o endividamento, a solvabilidade, a rendibilidade do capital próprio, a rendibilidade do ativo e a autonomia financeira. Relativamente às variáveis não financeiras, conclui-se que a exportação e o número de funcionários são determinantes na previsão de falência de uma empresa do setor da construção. Este artigo contribui para a literatura, pois apresenta variáveis não financeiras como determinantes na previsão de falência no setor da construção civil em Portugal.
Reseña de García, N. (2018). Understanding Mattessich and Ijiri: A Study of Accounting Thought. Bingley: Emerald Publishing Limited
Authors: Pungitore José Luis
Published: January 2019

La profesora Nohora García ha realizado un análisis profundo de la obra de Richard Mattessich y de Yuji Ijiri, haciendo foco en sus principales —y seminales— obras: Accounting and Analytical Methods (Mattessich, 1964) y Theory of Accounting Measurement (Ijiri, 1975), aunque también incluye artículos que los han precedido y sucedido en su elaboración.
Learning Strategies Used by High and Low Achievers in the First Level of English
Authors: Samperio Nahum
Published: January 2019

This study tries to identify the possible differences in the types of strategies and their frequency of use in low and high achievers of English in a language centre in a university in Tijuana, Baja California, Mexico. Data were collected using a mixed-methods research methodology. The sample consists of 27 students with a high score and 30 with a low score on the achievement test. The results show that students in both categories use similar strategies; the difference lies in the frequency of use and how they use the strategies. Finally, from the qualitative data emerges a list of strategies used by high achievers.
EFL Teachers’ Perspectives on the Role of English in Two Mexican Private Universities
Authors: Despagne Colette
Published: January 2019

In Mexican higher education, the spread of English has become a tool in the internationalization process of universities. However, language has been sidelined in the discourses of globalization and internationalization. Hence, this ethnographic case study aims to look at the spread of English in Mexican higher education through two private universities. It focuses on the universities’ internationalization process, and how English as a foreign language teachers perceive the role of English in this process. Findings show that while English as a foreign language teachers support linguistic ideologies that promote the spread of English as a natural and apolitical phenomenon, at the same time they also warn of ideological implications such as language hierarchies, cultural homogenization, and English linguistic discrimination.
A Discussion on English Language Students’ Body Image: Beauty Standards and Fatness
Authors: De Lima Bastos Pedro Augusto , Pessoa Rosane Rocha
Published: January 2019

In this qualitative study, we intend to discuss how adolescent students in a Brazilian public school classroom define their body image and personalize the themes beauty standards and fatness. Grounded on a critical approach to language teaching, these two social themes were problematized in eight lessons of Ensino Médio (secondary education). The discussion of the empirical material suggests that (1) body image is strongly connected to gendered relations, making life experiences of men and women different based on the bodies they have, and (2) beauty standard and fatness are strongly related to students’ lives since twelve out of nineteen students personalized the themes by telling oppressive stories they went through because of their bodies.
Coaching as a Professional Development Strategy for Adjunct Instructors in a Colombian University
Authors: Gómez Palacio Claudia , Gómez Vargas Deisa Enid , Pulgarín Taborda Hadaluz
Published: January 2019

This article reports the results of a study in which coaching was used as a professional development strategy with five foreign language adjunct instructors at a public university in Colombia. A questionnaire, coaching sessions, interviews, and both coaches and coachees’ reports were the data collection sources. Results showed that adjunct instructors consider coaching a useful professional development strategy that should be offered to all foreign language instructors. In addition, trust and genuine interest were considered determinant when administrators implement this professional development strategy, and self-leadership was crucial when foreign language instructors make decisions regarding their own professional development.
The Use of Plotagon to Enhance the English Writing Skill in Secondary School Students
Authors: Guzmán Gámez Derly Yuleith , Moreno Cuellar Johana Andrea
Published: January 2019

This paper reports on an action research study aimed at implementing Plotagon to enhance English writing skill. The study involved 18 students from 10th grade of a public secondary school in Colombia. The findings showed that the use of Plotagon promoted students’ motivation to write through an interactive and attractive interphase to create digital stories. Consequently, students created their own digital story working in pairs and as a result increased their vocabulary, improved their English writing skill and other language skills. The data collection tools (surveys, tests, journals, observations, and dialogs as students’ production) showed that Plotagon is a pedagogical tool that promotes students’ English writing in a fun and meaningful way.
O WhatsApp como ferramenta para a prática oral e escrita em língua inglesa
Authors: Dos Santos Cíntia Pereira , Silva Luciana Idalgo da , Dutra Alessandra
Published: January 2019

The new technologies are applied in the education context through an amount of resources and interaction tools by students and teachers. In this way, this study aims at analyzing the oral and written production of students from a Simple Present activity in the WhatsApp; as well as, evaluating the pronunciation in English Language of these students. As methodological procedures, the study used bibliographical, field, experimental and analytical research, being developed with graduating members of an English Language course offered in a University in North of Parana. As results, it was observed that the activity was acquired by a large part of the students, proving that the use of technologies in the classroom contributes to students’ foreign language learning. Based on this research, it is expected to offer a contribution to the foreign language area, as a way to motivate teachers to carry out classroom activities in which students could practice their orality using the new technologies.
Teaching Language, Promoting Social Justice
Authors: Anwaruddin Sardar M.
Published: January 2019

The article is concerned with teaching language by utilizing social media from a social justice perspective. It makes an argument for taking a dialogic approach to pedagogy based on serendipity and contingent scaffolding. The article is inspired by a small but growing body of literature known as Critical Computer-Assisted Language Learning. First, I provide a brief introduction to Computer-Assisted Language Learning, and its recent turn toward a critical approach. Then, I discuss social media, and what “social” means when it precedes the word “media.” Next, I describe how social media are being used in language education, and why the dominant methods of use may not prepare language learners as justice-oriented democratic citizens. A key barrier I identify in this regard is media users’ increasing ability to filter what they want to see and hear. To re-think the pedagogical uses of social media, I draw from Mikhail Bakhtin’s works and propose a dialogic approach, which may be helpful for language teachers and teacher educators.
On Inductive Abilities of Latent Factor Models for Relational Learning
Authors: Trouillon Théo , Gaussier Eric , Dance Christopher R. , Bouchard Guillaume
Published: January 2019

Latent factor models are increasingly popular for modeling multi-relational knowledge graphs. By their vectorial nature, it is not only hard to interpret why this class of models works so well, but also to understand where they fail and how they might be improved. We conduct an experimental survey of state-of-the-art models, not towards a purely comparative end, but as a means to get insight about their inductive abilities. To assess the strengths and weaknesses of each model, we create simple tasks that exhibit first, atomic properties of binary relations, and then, common inter-relational inference through synthetic genealogies. Based on these experimental results, we propose new research directions to improve on existing models.
Modeling of the refractory's and slag's phase composition, the slag adjustment optimization and the ladle refining slag's stabilization
Authors: Kozlov V. V. , Shevchik A. P. , Suvorov S. A. , Arbuzova N. V. , Kuznetsov D. V.
Published: January 2019

The modeling technique was proposed for the phase formation in the CaO‒MgO‒Al2O3‒SiO2‒FeO‒Fe2O3multicomponent oxide system. The technique can be used to predict the equilibrium phase composition for both the refractory and refractory-slag systems, as well as to modify the metallurgical slag's chemical composition, to extent the metallurgical unit's refractory service life, and in order to attaint the refractory-slag systems the mineral binding properties.Ill. 2. Ref. 7. Tab. 8.
Numerical study of the dust-air current around the spherical suction unit screened by the circular swirling jet. Part 2. The dust particle dynamics
Authors: Gritskevich M. S. , Logachev K. I. , Averkova O. A. , Tkachenko V. A.
Published: January 2019

The method is regarded for the pollutions screening with using the local suction hood. The investigating results are given for the particle behavior in the air ﬂow nearby the local suction unit screened by means of the circular swirling jet, located both over the impermeable surface and in the closed space inside the aspiration hood.Ill.11.
The new kind of the LLC «GIR-ENGINEERING»'s refractory products
Authors: Nemsadze G. G. , Dzhodzhua R. A. , Smirnov A. N. , Sharandin K. N. , Ryabyi D. V.
Published: January 2019

The new refractory products of the «GIR ENGINEERING» Company is presented in the article. The data on the physical and chemical properties of the manufactured articles are represented.Ill.2. Tab. 3.
The study of compositions based on parkent kaolin clay
Authors: Rumi M. Kh. , Irmatova Sh. K. , Zufarov M. A. , Fayziev Sh. A. , Mansurova E. P. , Urazaeva E. M. , Nurmatov Sh. R.
Published: January 2019

The results of studies of the structure and composition of compositions based on red-burning kaolinite clay and calcium carbonate, heat-treated at 500oC, in the process of acid activation are presented. It is shown that when a 12 % solution of H2SO4is applied, leaching of iron and aluminum ions and the formation of calcium sulfate occur while maintaining the structure of kaolinite. The introduction of liquid glass into the composition of the material leads to the destruction of the structure of kaolinite, which contributes to an increase in the rate of extraction of aluminum ions during the subsequent acid activation. The components of the compositions with Ca2+and Fe3+in the presence of liquid glass are passivated by active amorphous silica formed during the reaction of liquid glass with CO2air.Ill. 2. Ref. 17. Tab. 1.
The influence of the structure of refractory products on their performance properties
Authors: Isagulov A. Z. , Kulikov V. Yu. , Kvon S. S. , Dostaeva A. M. , Shcherbakova E. P.
Published: January 2019

The inﬂuence of the structure of refractory products on such operational properties as slag resistance and heat resistance is considered. As samples, a conventional chamotte refractory (standard) and chamotte refractory made according to a new technology using non-stationary pressing pressure were used. It is shown that the porosity, slag resistance and heat resistance of products manufactured using unsteady pressure is higher than that of the standard.Ill.4. Ref. 4. Tab. 2.
Modern electric arc furnace processes and their requirements for improved lining concepts
Authors: Hanna A. , Zettl K.-M.
Published: January 2019

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The investigation of the modified refractory concrete in terms of the clay filler's kind
Authors: Zdаnyavichus P. , Antonovich V. , Boris R. , Stonis R. , Shukis R. , Vitek E.
Published: January 2019

The properties of the conventional refractory concrete modified by means of the microsilica and the antiflocculant additions including the different kinds of the fire clay filler were investigated in the article. It was established that the refractory concrete with the filler Bos145 (about 44 % of Al2O3) had the smaller open porosity, and both high density and the ultimate compressive strength comparing to these characteristics which the concretes with the fillers Bos125 and Bos135 had (about 26 and 37 % of Al2O3respectively). Also it was found out that independently of the fire clay filler's kind another SiO2-based addition promoted the increase of the concrete's alkaline resistance by the factor of 5 and more. It was shown that this SiO2-based addition is effective at the temperatures up to 1100 °C, as at 1200 °C the chamotter concrete's porosity grew up and the resistance of the material against the alkaline melt decreased considerably.
Heat-reflecting ceramic materials based on potassium poly-titanate and silicon oxide.
Authors: Gorokhovskii A. V. , Meshcheryakov D. V. , Burmistrov I. N. , Sevryugin A. V.
Published: January 2019

The possibility is studied to obtain the porous ceramic composite with the low heat conductivity and high heatreflecting ability on base of the raw mixture of potassium poly-titanate and different silicon oxide modifications. It was shown that the silicon oxide introduction favors the glass potassium-silicon phase formation which acts as a binding agent and promotes the ceramic composite structure creation, the composite consisting of interwoven high-strength fibrous K2Ti6O13 crystals, bound by means of evenly spread glass phase.
The recycling materials using in the refractory production
Authors: Il'in G. I.
Published: January 2019

The investigating results are given for the ferrouschromium slags using as the refractory materials to prepare the refractory concretes. The temperature range of their application was defned. It was established that the magnesia oxide addition considerably reduced the Chromium VI formation during service in composition of the refractory materials manufactured on base of the ferrous-chromium slags. Ref. 5. Tab. 4.
The influence of the admixture to the Al2O3‒MgO‒MnO system and of the firing temperature on the electro-fused corundum composite ceramics sintering
Authors: Moe Aung Chzho , Lukin E. S. , Popova N. A.
Published: January 2019

The inﬂuence of the eutectic composition addition to the Al2O3‒MgO‒MnO system on the structural ceramics' sintering was investigated in the article. The initial material was the electro-fused corundum F-1000 with the average particle size of 10 microns. The additive powder have been prepared in course of the thermolysis of the alumina hydroxyl together with the manganese carbonate and magnesia carbonate salts. The spinel MgO· Al2O3and MnO· Al2O3have been synthesized separately. It was established that when the addition contents was equal 15 weight percent after the burning at 1550 °С the ceramics density achieved 3,86 gram/cm3 the open porosity being 0,3 %, and the ultimate bent strength achieved 211 MPa.Ill.3. Ref. 8. Tab. 1.
The influence of the high-temperature deformation on the aluminum-phosphate composites structure
Authors: Shayakhmetov U. Sh. , Khalikov R. M. , Khamidullin A. R. , Shayakhmetov A. K. , Khaidarshin E. A.
Published: January 2019

The physical, chemical and structural developments taking place in the aluminum-phosphate composites when heating under the load were investigated in the article. The X-Ray diﬀraction analysis, the electronicoptical and scanning microscopy with embedded energy-dispersive spectral measurement system were used to study both the compositions of the resulting products after the α-Al2O3‒phosphate binder composite's hardening and the transformations of these products in the high-temperature interaction regions. The investigating results allowed to predict the ceramics' deformation behavior in service and to optimize the production technique for the refractory ceramic materials with the tailored characteristics.Ill.8. Ref. 9.
Use of periclase-carbon lining in DC arc melting furnaces during processing of secondary raw materials
Authors: Ivanov A. G. , Bagan M. A. , Baltacheev D. N. , Cherepanov D. E. , Lopatin V. A. , Saigashkin I. O.
Published: January 2019

The experience of operating a DC arc furnace in JSC "Krastsvetmet" for recycling of secondary raw materials using periclase-carbon products as a working layer of lining is presented. A comparative analysis of the operation of a DC arc furnace with periclase and periclase-carbon lining is described.Ill.2.
The experience of the SC «Borovitch Refractory Works» production application at the SC «Oskol Electrometallurgical Works»
Authors: Mozhzherin A. V. , Sakulin A. V. , Margishvili A. P. , Gershkovich S. I. , Iksanova A. N. , Korzhavin A. Yu. , Vitovskii A. V. , Musevich V. A. , Khaichenko M. V.
Published: January 2019

The results of the cooperation between SC «Borovitch Refractory Works» and the SC «Oskol Electrometallurgical Works» (SC OEW) with regard to the supplying and operational activity of the wide range of the refractory production items are given in the article. The basic development trends are pointed out which can improve and optimize the physical and chemical parameters of the supplied refractories. The main innovative refractory materials and the completed projects are regarded which have amended the technical and economic indexes of the heat vessels at the SC OEW engaged at the main metallurgical processing stages.Ill.7. Ref. 4. Tab. 5.
Pulsed rapid cooling method of the massive relating to heat bodies
Authors: Pribytkov I. A. , Terekhova A. Yu. , Kondrashenko S. I.
Published: January 2019

The data are presented on the pulsed rapid enhanced cooling of the massive related to heat bodies. The pulsed rapid heating consisting of the alternating enhanced heating and retardation during which the main part of the heat applied to the metal by convection, supposes the elevated temperature raise rate just when heating. These cooling conditions inﬂuence substantially on the radial temperature distribution inside the metal during the cooling.Ill.5. Ref. 8.
The influence of the cenosprehes addition on the heat-resistant lightweight ceramics
Authors: Pundiene I. , Prantskevichiene I. , Kligis M. , Kairite A. , Girskas G.
Published: January 2019

The investigating results are given for the cenosphere (the coal combustion wastes) inﬂuence on the alumina cement hydration and on the exothermic reaction parameters. It was established that the cenosphere content's increasing inhibits the cement hydration, decreases the samples density to 40 % after sintering at1200 °C, as well as it reduces the strength to 60 %, and the shrinkage to 95 % comparing to the reference samples. Judging by the strength to density ratio the optimum quantity of cenospheres in the alumina cement composition is 5‒10 %.Ill.7. Ref. 19. Tab. 2.
Thromboelastometric evaluation of coagulation profiles of cold-stored autologous whole blood v1
Authors: Iwata Shihoko
Published: January 2019

Preoperative autologous blood donation is a well-established procedure to reduce the need for allogeneic blood transfusion; however, this procedure is expected to preserve and replace red blood cells rather than coagulation factors. Threre are few studies about the coagulation profile of cold-stored autologous whole blood collected for clinical use. We hypothesized that coagulation activity is maintained in cold-stored autologous whole blood for up to the 35-day shelf life, mainly because the fundamental coagulability of fibrinogen is preserved.
Cover Vol 3 No 2 2018
Authors: Fisika Wahana
Published: January 2019

DAFTAR ISI RUANG LINGKUP DAN INFORMASI JURNAL DEWAN REDAKSI KATA PENGANTAR DAFTAR ISI Identifikasi Daerah Longsor Kecamatan Bagelen menggunakanMetode Mikrotremor(Gofur Dyah Ayu Gilang Pertiwi, Nugroho Budi Wibowo, Denny Darmawan)Aplikasi Reservoir Saturation Tool (RST) Log Pada Cased Hole Well UntukEvaluasi Kandungan Hidrokarbon Di Cekungan Kutai, Kalimantan Timur(Priyo Hutomo, Yatini)Penyimpangan Titik Pusat Optik Lensa (OC) Dengan Jarak Pupil (PD) PemakaiKacamata(Hanna Nurul Husna, Fidiawati Bambang, Dian Laela Sari)Penentuan Suhu Nol Mutlak melalui Praktikum Termodinamika menggunakanHukum Charles(Defrianto Pratama, Ratu Fenny Muldiani, Kunlestiowati Hadiningrum)Prototipe Sistem Kendali Suhu dan Kelembaban Kandang Ayam Broiler melaluiBlynk Server berbasis Android(Fitri Puspasari, Imam Fahrurrozi, Trias Prima Satya, Galih Setyawan, MuhammadRifqi Al Fauzan)
Indolocarbazole derivatives – a promising class of anticancer drugs
Authors: Kiseleva M. P. , Pokrovsky V. S. , Tataskiy V. V. , Borisova L. M. , Golubeva I. S. , Ektova L. V.
Published: January 2019

The paper discusses the possible mechanisms of antitumor action of indolocarbazole derivatives. Here we present a data that show interaction drugs based on indolocarbazole derivatives with several intracellular targets and consequently activation different pathways of cell death. Also we present results of our studies on the mechanisms of antitumor action of compounds LCS-1006 and LCS-1208 synthesized in the N.N. Blokhin Russian Cancer Research Center, Ministry of Health of Russia.
Prognostically significant bone marrow cellular content changes in diffuse large B-cell lymphoma
Authors: Jiao Cheng , Zeynalova P. A.
Published: January 2019

Introduction. Increasing of blast cell percentage in bone marrow of diffuse large B-cell lymphoma patients is a sign of unfavourable prognosis. We estimated the frequency of this phenomenon and made attempts to idenify minimal bone marrow involvement in DLBCL by flow cytometry.

Materials and methods. Study has been done in 60 DLBCL patients. Diagnosis in all cases was done according to WHO (2008) criteria. Bone marrow study was done on smears (myelogram). Immunophenotypic study was done with a large panel of B-lineage monoclonal antibodies as well as kappa and lambda light chains to membrane immunoglobulins.

Results. Increase in blast cell content in bone marrow was noted in 73.3 % of DLBCL patients. That group of patients had lower surviv al. We used the following methods for identification of monoclonal B-lymphocytes: monoclonality according to membrane light immu noglobuline chains within mature B-lymphocytes and aberrancy of immunophenotype. Levels of different B-cell antigen expression – CD20, CD21, CD22, CD24. It was identified B-lymphocytes with aberrant expression of СD21.

Conclusion. The most informative methods of identification of minimal bone marrow involvement in DLBCL are estimation of clonality according to light chain expression of mature B-lymphocytes (CD45++CD20+CD5–), as well as assessement of aberrancy of CD21 expression of mature B-lymphocytes.