bluuebunny/crossref_metadata_2025 huggingface dataset:
Performance Analysis in Palm Oil Industry Using Supply Chain Operations Reference (SCOR) Model
Authors: Sarjono Haryadi , Christofer Kevin , Nayoan Georgie Florensky , Nugraha Mochamad Derisman
Published: November 2022

The research aims to map the process and measure supply chain performance in the palm oil industry using the Supply Chain Operation Reference (SCOR) Model 11.0 approach. It was considered that this industry could influence the country’s foreign exchange. The object of research was PT Perkebunan Nusantara I (PTPN I), Aceh. It was chosen because, compared to other PTPNs in the Sumatra region, the lowest productivity rate for palm oil processing was around 2,8 tons/ha, inversely proportional to the land area owned by state plantations of 42.233 ha. Data were collected using field survey methods and interviews with company managers involved in the company chain process. This measurement process was useful for measuring achievements and correcting ineffective supply chain processes. The results show that supply chain performance analysis for performance metrics has not reached the expected target. It describes Perfect Order Fulfillment (POF) with a gap of 98%, Order Fulfillment Cycle Time (OFCT) of 3,93 days, Total Cost to Serve (TCTS) of 71%, Cash to Cash Cycle Time (CCCT) of 242,32 days, and Return on Supply Chain Fixed Assets (ROF) of 0,123 times, when viewed from the calculation of the Lost Opportunity Measurement (LOM). In the research, four recommendations for improvement are given based on the problems that occur in the company using the best practices of the SCOR model. They are manufacturing reliability improvement, batch reduction, Single Minutes Exchange of Dies (SMED), and make-to-order fulfillment strategy.
The Role of Network Security in Class Conference During COVID-19 Pandemic
Authors: Edbert Ivan Sebastian , Pramaitama Julio , Tio Kevin , Rizky Muhammad , Aulia Alvina
Published: November 2022

Security is crucial for the network. But there are still system leaks, especially in class conferences during the pandemic. Because of a lot of data exchange and data entry, some viruses are difficult to identify. So, the role of network security is vital. Many viruses spread through links, and others can access cases of misuse of links; the issue is called Zoom bombing. So, from managing the instability of data in and out of conference classes during this pandemic, many activities are carried out online that awareness of more comprehensive network security. With the COVID-19 pandemic, class conferences are prevalent in today’s world. Millions of people use it for various reasons, and one of them is for education. However, there are issues related to the network’s security where users’ data was stolen and impersonated or network trafficking, which will cause fault and disruption in the network. This research have 3 methodologies include Systematic Literature Review, Research Questions (identify the focus of the literature review, which helps process the data more clearly), Result Finding (the study of an existing paper with specific keywords to answer the research questions). As the result, it can be concluded that there are many ways to prevent attacks by improving the network’s security such as network security defense mechanisms and firewall. So that everything can be petrified in terms of comfort in meet conferences so that class conferences activities can run safely.
Designing IoT-Based Smarthome System With Chatbot
Authors: Ario Muhamad Keenan , Leon David , Pratama Muhammad Rizki , Pamungkas Gentrya Wirya
Published: November 2022

Smart home system aim to maximize surveillance, monitoring, and security. This system is integrated with telecommunications and control systems from the microcontroller to create the Internet of Things (IoT). Nowadays, home appliances are integrated with the Smart System that connected to the internet. On the other hand, messenger applications now integrated with chat bot with Artificial Intelligence to make user easier to communicate. This trend made a possibility to implement a system where a home appliance can be operated by only using a messenger application. In this research, a Smart home system designed with a client-server system based on Raspberry Pi as microcontroller and Telegram Messenger as interface that perform the control communication. The process separated into three stages: design, implementation, and result. The design consists of designing the server, interface, and Smart Home control system. To test the performance, the Messenger Bot are compared with other direct controller application. The result show that the Telegram Messenger application is suitable and more convinient for being the IoT controller.
Gamification Impact on Human Aspects of the Organization
Authors: Uppalike Meghashree
Published: November 2022

The term gamification is becoming more critical in virtual games and academia, and the economy. Gamification is described as the use of game elements in non-gaming areas such as companies. The purpose of this study is to find out how much gamification can be used in HR. The paper is divided into three parts. First, let's take a closer look at the concept of HR gamification, followed by a theoretical explanation. Later, the document describes the methodology, results, and conclusions used in the study.
Board Game Design for Conservation Organization
Authors: Harisa Ardiawan Bagus , Umami Zahrotul , Saputra Filmada Ocky
Published: November 2022

A Javan hawk-eagle conservation organization, Yayasan Konservasi Elang Indonesia, is struggling with its marketing & publication activities. The organization then uses a board game to help their conservation works. There are educational and conservative purposes embedded in the game design to be a formal framework to overcome the challenge. Using a board game as a conservation tool engages the players and deepens their understanding of the topic, Javan hawk-eagle. The process we use to develop the framework includes mapping the learning objectives to the game component and actions, board game design steps, and implementation and production of the board game. We then compare the cognitive aspect of the educational goal in a pre-test and post-test of the learners.
Using Technology-Based Media for Teaching Speaking in Intercultural Education
Authors: Rokhayati Titi , Widiyanti Ana
Published: November 2022

The research aimed to study how did mobile-phone were used for teaching speaking in intercultural education? and was the use of mobile phone for teaching speaking in intercultural education effective? Intercultural competence could be seen in the teaching of speaking since the students had to reflect their ideas and opinions orally. Thus, the speaking ability would be much supported by intercultural education. To reach this, the use of technology-based media like mobile-phone in teaching speaking was needed to make it easier and more interesting. In the past decade, several studies have sought to determine the use of technology in education; however, in the university context, the issues of mobile phone used for teaching speaking in intercultural education had not been discussed extensively. The research employed explanatory sequential mix-method research. The instrument of the research was an observation, questionnaire, and test. The research population was 40 students of the fifth semester of the English Education Program of Purworejo Muhammadiyah University. The finding shows that mobile phone is used as the primary tool to access the material and learning platform. Using mobile phones, the student’s speaking ability is improved by 18,3%. In addition, the finding shows that the use of mobile phones for teaching speaking in intercultural education is effective to help the teacher in delivering the material and boosting the students’ motivation to speak.
Subtitling and Dubbing of Idiomatic Expressions in the American TV Series WandaVision
Authors: Agung I Gusti Ayu Mahatma
Published: November 2022

The research aimed to find out the translation strategies applied in the subtitling and the dubbing of idiomatic expressions in the television series WandaVision (2021). Moreover, the research also aimed to reveal whether the subtitling and the dubbing of the idiomatic expressions are source language-oriented or target languageoriented. The descriptive qualitative approach was applied in the research. The data were analyzed using the taxonomy for rendering extralinguistic cultural references in subtitling proposed by Pedersen. The taxonomy was used to analyze the data since it was specifically designed for subtitling and audiovisual translation. The results show that there are various strategies applied in subtitling and dubbing. In subtitling, the translation strategies applied are substitution, direct translation, generalization, and the combination of substitution and omission. The translation strategies applied in the subtitling are related to spatial and temporal constraints. As a comparison, the translation strategies applied in dubbing are substitution, direct translation, generalization, and the combination of substitution and specification. The strategies are applied based on the consideration that spoken language features should be included in the dubbing. Based on the translation strategies applied, it can be concluded that both the subtitling and the dubbing are target language-oriented.
Syntactic Complexity of Online Opinion Articles Published in South East Asian Countries
Authors: Muarif Muarif , Indarti Dwi
Published: November 2022

The research investigated the syntactic complexity of opinion articles published in online newspapers from English as a Second Language (ESL) and English as a Foreign Language (EFL) countries in South-East Asia (SEA). The aims of the research were, first, to analyze the types of Syntactic Complexity (SC) of opinion articles in online news media. The second was to seek the difference in syntactic complexity in online opinion articles between ESL and EFL countries. The third was to seek whether there was a significant difference in terms of types of syntactic measurements between ESL and EFL countries. To answer the questions, the research applied both quantitative and qualitative methods. Twelve opinion articles from online news media in SEA countries were derived from Malaysia and Singapore, which represented ESL countries, and Indonesia and Thailand, which represented EFL countries. The data were analyzed by using an L2 syntactic complexity analyzer. The Second Language Syntactic Complexity Analyzer (L2SCA) program displayed fourteen syntactic complexity measures divided into five types of measurements such as the length of production, sentence complexity, subordination, coordination, and particular structures. From comparing overall ESL and EFL countries and each of the opinion articles topics, the research results reveal that opinion articles of ESL countries show a higher score on the lengthof production, sentence complexity, subordination, and particular structures than EFL countries. Meanwhile, in coordination type, EFL countries display a higher number of a score than ESL ones. The research indicates there is no significant difference between ESL and EFL countries since the p-value of each type of syntactic complexity is higher than 0,05.
Antileukotriene drugs as a tool for improving the quality of life in patients with allergic rhinitis
Authors: Simsova V. A. , Ovchinnikov A. Yu. , Miroshnichenko N. A. , Ryabinin V. A.
Published: November 2022

Introduction. Allergic rhinitis (AR) is immunoglobulin E (IgE) mediated disease. Which, after exposure to allergens, manifests itself with various symptoms such as sneezing, runny nose, nasal itching, and nasal congestion, which seriously affects the quality of life of patients. In some patients, AR poses a risk of developing serious mental disorders. Currently, various medicines are used for treatment.   Objective. Consideration of the effectiveness of AR therapy with antileukotriene drugs, depending on the mental state of the patient.   Materials and methods. The study involved 200 people diagnosed with AR. The patients were divided into 2 groups: group 1 (100 people) with basic therapy with intranasal glucocorticosteroids (inGCS – mometasone furoate) and group 2 (100 people) – inhalers in combination with an antileukotriene drug (montelukast). All were screened for the presence of a depressive disorder. The tactics of case management and prescription of drugs were defined by the level of depression. Patients with AR have mental health problems that correlate with AR symptoms.

   Results. Patients of the 1st group, who did not achieve complete relief of AR symptoms, when assessing their mental state using the PHQ-2 and PHQ-9 questionnaires, showed a mild depression (23 people). The symptoms of AR were stopped, when an anti-leukotriene drug was added to the therapy.   Conclusions. With the ineffectiveness of the basic therapy of inGCS and a negative assessment of the patient’s mental state, the use of an antileukotriene drug is justified to improve the level of depressive mood and complete relief of symptoms of AR.
Emotional burnout syndrome in healthcare professionals
Authors: Shcherbakova I. L. , Megrelishvili S. M. , Kliachko D. S. , Sugarova S. B. , Anosova L. V.
Published: November 2022

Currently, one of the most pressing concerns of labor psychology and healthcare is emotional burnout in healthcare professionals. During the COVID- 19 pandemic this condition has become very significant due to it takes a lot of physical, phychoemotional and ethical commitment of medical personnel. Emotional burnout is a syndrome that derives from chronic stress and leads to the depletion of personal, emotional, and energy resources of a person in the professional life. It is an dynamic sequential process and relevant to stress stages (the alarm stage, the resistance stage and the exhaustion stage). There are many various factors inducing the burnout syndrome: social, political, economic, bureaucratic, etc. In the process of studying this phenomenon, different models of emotional burnout were proposed. The most famous model is the three-part model of burnout by С. Maslach, which includes emotional exhaustion, depersonalization and a decrease in personal achievements. In Russia V. V. Boyko has been studying the burout phenomenon. There are three main stages of emotional burnout (alarm, resistance and exhaustion), which have a close connection to stress stages; each stage has a specific combination of symptoms. According to a number of authors, burnout syndrome is closely related to empathy, therefore, it is necessary to study the relationship between the level of empathy and the degree of emotional burnout in healthcare professionals for planning further psychological support for the prevention of this syndrome.
Therapeutic and diagnostic approaches in the treatment of chronic tonsillitis
Authors: Korkmazov M. Yu. , Yastremsky A. P. , Kornova N. V. , Lengina M. A. , Korkmazov A. M.
Published: November 2022

Introduction. The relevance of the treatment of chronic tonsillitis is due to both the high prevalence and severity of the course of the disease with the variable development of tonsillogenic complications, both local and general. Important aspects are not always effective results of conservative methods of treatment, including the use of antibacterial drugs and, as a result, a decrease in the quality of life of patients.   Objective. Based on the dynamics of blood leukocyte indices and local signs of chronic tonsillitis, to determine the effectiveness of a course of treatment using an effective antimicrobial agent of plant origin in patients of various age groups.

   Materials and methods. A prospective study was conducted in 494 patients aged 8 to 58 years who were treated on an outpatient basis for more than two years. Depending on the form of the disease and ongoing therapy, patients were randomly divided into 4 subgroups.   Results and discussion. Evaluation of the effectiveness of treatment in groups of patients was carried out according to the indices in the leukocyte formula. A decrease in the average values of the indices was verified in most patients, which manifested itself in the activation of the phagocytic process with an antimicrobial herbal preparation and made it possible to reduce the manifestations of local and systemic clinical symptoms of chronic tonsillitis.   Conclusion. Based on an objective assessment of the manifestations of local symptoms of chronic tonsillitis and an analysis of the dynamics of leukocyte blood indices, the effectiveness of a course of treatment with the inclusion of an antimicrobial agent of plant origin in patients of various age groups was shown.
Efficacy and safety of tofacitinib in the treatment of rheumatoid arthritis: results of 10 years of use
Authors: Chichasova N. V. , Lila A. M.
Published: November 2022

The article presents a review of the basic data on the efficacy and safety of the drug tofacitinib, the place of the drug in the treatment of rheumatoid arthritis (RA) patients according to current international and Russian recommendations. Data on the mechanism of action of Janus kinase inhibitors, the spectrum of cytokines inhibited by tofacitinib is presented. The results of major randomised controlled trials demonstrating high clinical efficacy in patients who have not responded to methotrexate (MT) and other synthetic classical anti-rheumatic drugs (SCARDs), genetically engineered biologic drugs, are presented, with equal efficacy of tofacitinib when given as monotherapy or in combination with MT or other SCARDs, with adalimumab. The safety of tofacitinib with long-term treatment (up to 9.5 years) is analysed. The cardiovascular tolerability of tofacitinib is presented separately, considering the proposals discussed at the last EULAR 2022 Congress. The low incidence of serious cardiovascular adverse events, including venous thrombosis and thromboembolism over the long-term follow-up period, and the risk of these adverse events, which was no higher than on the selective Janus kinase inhibitor baricitinib, are presented. Changes in laboratory parameters (haemoglobin, neutrophil count, aminotransferase concentration) during tofacitinib administration are described. Domestic data on the use of tofacitinib in the treatment of RA patients is demonstrated. An association was shown between early clinical response to tofacitinib (5 mg twice daily) and a reduction in RA activity after 3 and 6 months in RA patients. Tofacitinib in real clinical practice showed early development of effect (by week 12) in the group of patients who did not respond to MT and in 60% of cases to genetically engineered biologic drugs, with respect to indicators of inflammatory activity of RA and functional status of patients. Domestic authors have noted the high safety of tofacitinib. A domestic generic version of the original drug tofacitinib has been reported to be registered for the same indications: RA, psoriatic arthritis, plaque psoriasis, ulcerative colitis.
Intravenous thrombolysis in ischemic stroke: 10 rules for the practical neurologist
Authors: Кulesh А. А. , Demin D. А.
Published: November 2022

Intravenous thrombolysis (IT) with recombinant tissue plasminogen activator has remained the main method of reperfusion therapy in ischaemic stroke for a quarter of a century. The main trends in the use of IT in recent years are the expansion of the therapeutic window using additional methods of neuroimaging, reducing the number of contraindications and introduction into clinical practice of bolus forms of drugs. Providing IT to the largest number of patients should be considered a major challenge for the primary vascular department. This article presents 10 clinical rules for extending IT in stroke while ensuring its efficacy and safety: 1) conduct IT in suspected stroke; 2) conduct IT in patients over 80 (and even 90) years of age; 3) conduct IT in minor but disabling stroke; 4) conduct IT in minor vertebrobasilar stroke and central acute vestibular syndrome; 5) perform IT in cases of large artery occlusion; 6) perform IT in suspected lacunar stroke and chronic neuroimaging changes (lacunas, white matter hyperintensity, atrophy); 7) reduce door-to-needle time, use thrombolytics with bolus administration; 8) use neuroimaging options (CT perfusion, MR perfusion, MR DWI/FLAIR) to expand the therapeutic window; 9) ensure the safety of IT; 10) be prepared for complications. Increasing the frequency of IT should not be seen as a goal, but intensifying the use of this method of treatment is associated with the improvement of all areas of the diagnostic and treatment process in the clinic and the improvement of stroke outcomes.
Iğdır Merkez ve Bazı Köy Okullarında İnsan Sağlığı Üzerinde Zararlı Etkisi Olduğu Düşünülen Uçucu Organik Bileşiklerin Analizi
Authors: MERT Erkan , ARAS Abdülmelik
Published: November 2022

İş sağlığı ve güvenliği kapsamında, okullarda çalışanların ve öğrencilerin maruz kaldıkları ve insan sağlığı üzerinde etkisi olduğu düşünülen uçucu organik bileşiklerin ölçümü yapılmıştır. Bu çalışmanın değerlendirilmesinde ilgili mevzuat ve standartlarda belirlenen sınır değerleri referans alınmıştır. Çalışma kapsamında elde edilen numuneler Gaz kromatografisi-kütle spektrometresi (GC/MS) ile ölçüme tabii tutulmuştur. Ölçüm için Iğdır ili ve çevresinde belirlenen 10 okulda pasif hava örnekleme izleme cihazı 12 günlük bir zaman dilimi için bırakılmıştır. Elde edilen bulgulara göre toluen (6.8 µppm), aseton (5.4 µppm) ve etanol (39.5 µppm) değerleri okulların koordinatlarına göre farklılık göstererek diğer bileşiklere kıyasla yüksek bulunmuştur. Bu değerler kabul edilebilir referans aralıklarında olup, daha hassas cihaz ve yöntemlerle ileri ölçümler önerilmektedir.
Bakteriyel Kaynaklı Lipaz Geninin Pichia pastoris’te Klonlanması, Ekspresyonu ve Rekombinant Enzimin Saflaştırılması
Authors: ERDEN KARAOĞLAN Fidan , KARAOGLAN Mert
Published: November 2022

Gıda endüstrisinde enzimler her türlü işleme ve üretim proseslerinde uygulama alanı bulan biyolojik katalizörlerdir. Süt işlemeden meyve suyu üretimine, et işlemeden ekmek üretimine kadar gıda sanayinin çeşitli alanlarında yaygın olarak ihtiyaç duyulan enzimlerden biri lipazlardır. Bu çalışmada, kodon optimize edilmiş Geobacillus stearothermophilus lipaz enzimini kodlayan genin, Pichia pastoris ekspresyon sisteminde güçlü ve indüklenebilir bir promotor olan AOX1 promotoru içeren pPICZA ekspresyon vektörü kullanılarak ekspresyonu yapılmış ve en yüksek lipaz enzimi üretimi gösteren klon belirlenmiştir. Belirlenen klon ile 400 mL indüksiyon besiyerinde 72 saat boyunca üretim gerçekleştirilmiş ve toplanan süpernatant örneğinde enzim aktivitesi, toplam protein ve SDS-PAGE analizi gerçekleştirilmiştir. Rekombinant lipaz enzimi Ni-NTA afinite kromatografisi ile saflaştırılmıştır. Saflaştırma işleminin her aşamasından alınan örneklerde SDS-PAGE analizi yapılmış ve her aşamada elde edilen örneklerde saflaştırma verimi hesaplanmıştır. Saflaştırma işleminden sonra analiz edilen örnekte, en yüksek üretim gösteren klonun 25.02 mg L-1 lipaz üretim seviyesine ulaştığı belirlenmiştir.
Mikroalg Kullanımının Ispanakta Bitki Gelişimi Üzerine Etkisi
Authors: GÜNSAN CAN Büşra , YILDIZ Muhsin , ŞENSOY Suat
Published: November 2022

Deneme, potansiyel bir biyogübre olan mikroalg (Chlorella vulgaris Beyerinck (Beijerinck)) kullanımının ıspanak bitki gelişimi üzerine etkilerini ortaya koyabilmek amacıyla gerçekleştirilmiştir. Sera koşullarında saksı denemesi olarak yürütülen araştırmada beş faklı mineral gübre dozu (kontrol, %25 mineral gübre (MG), %50 MG, %75 MG, %100 MG) ve iki mikroalg uygulaması (kontrol ve 2x107 alg mL-1) uygulama materyali olarak kullanılmıştır. Deneme sonunda, bitki boyu, kök boyu, gövde çapı, yaprak sayısı, yaprak alanı, yaprak taze ve kuru ağırlığı, kök taze ve kuru ağırlığı, yaprak oransal su içeriği, membran zararlanma indeksi, SÇKM (Suda çözünebilir kuru madde miktarı), klorofil miktarı, lipit peroksidasyonu ürünü malondialdehit (MDA) ve enzim aktiviteleri (SOD, CAT ve APX), belirlenip; yaprakta makro-mikro besin elementi [(Azot (N), fosfor (P), potasyum (K), magnezyum (Mg), kalsiyum (Ca), sodyum (Na), demir (Fe), mangan (Mn), bakır (Cu) ve çinko (Zn)] analizleri yapılmıştır. Elde edilen sonuçlara göre ıspanak gelişimi üzerine alg kullanımı bitki boyu, gövde çapı, yaprak alanı, yaprak yaş-kuru ağırlığı, kök yaş-kuru ağırlığı ve P değerleri üzerinde önemli artışlara yol açmıştır. Bununla birlikte Fe, Ca ve Na değerlerinde ise istatistiksel açıdan önemli düşüşler gözlenmiştir. Sonuçta, ıspanak yetiştiriciliğinde mineral gübre kullanımının %25 ile %50 oranlarında azaltılarak ve organik bir biyogübre olan mikroalg ile birlikte kullanımıyla birlikte daha çevre dostu ve sürdürülebilir bir üretim yapılmasının mümkün olacağı düşünülmektedir.
Yer Kaplaması ve Betonarme Kalıbı İmalatlarının Atık Değerlemesi ve İnşaatının Yönetimi
Authors: BETTEMİR Önder Halis , ZAFER Enes Hakan
Published: November 2022

Yer kaplaması ve betonarme kalıbı imalatı sürecinde kullanılan malzemenin boyutu ile kaplanan yüzey boyutunun uyumsuz olması, mekânın düzgün geometrik şekilde olmaması, kolon, kapı eşiği, tesisat bacası, şaft boşluğu gibi yapısal ve mimari elemanların kaplanacak yüzeyde düzensizlik oluşturması yer kaplaması işinde malzeme zayiatına yol açar. İnşaat süreci sıkışık zaman ve yoğun stres altında yürütüldüğü için malzeme zayiatını en aza indirecek yerleştirme örüntüsü ve malzeme kesim stratejisi üzerinde uğraşılamaz. Bu durum rastlantısal olarak çok yüksek malzeme zayiatlarına ve işçilik gereksinimlerine yol açabilmektedir. Bu çalışmada betonarme kalıbı ve yer kaplama malzemesi imalatlarının mekânın geometrisi ve malzeme boyutları dikkate alınarak en az zayiatın hangi malzeme boyutu ve yerleştirme örüntüsü ile oluştuğunu hesaplayan bir yöntem geliştirilmiştir. Hipotetik bir inşaat projesi vaka çalışması olarak kullanılarak malzeme miktarı ve imalat için gereken kesme miktarı hesaplanmıştır. Geliştirilen yöntemle tanımlanan malzeme boyutları arasından en az malzeme zayiatı olacak şekilde karo ve kalıp boyutları ile yerleştirme örüntüsü tespit edilmiştir. Sistemin kullanılması ile zayiat ve işçilik miktarları azalacağı için yapım maliyetleri de düşecektir. Böylece yüklenicilerin daha verimli yapı tasarımı ile daha etkin bir maliyet kontrolü olan Kaizen Maliyetleme tekniğini uygulayabilmeleri mümkün olacaktır.
İnterferon Beta-1a İlacının Enzim İnhibisyon Etkilerinin İncelenmesi
Authors: DURMAZ Lokman
Published: November 2022

Bu araştırmada, interferon beta-1a (IFNβ-1a) ilacının enzim inhibisyon etkileri araştırılmıştır. Bu amaçla IFNβ-1a ilacının insan eritrosit karbonik anhidraz izoenzimi I ve II (hCA I ve II) ile asetilkolinesteraz (AChE), bütirilkolinesteraz (BChE) enzimleri üzerine in vitro da enzim analizleriyle enzim inhibisyon etkileri açıklanmıştır. Bununla birlikte Sepharose-4B-L-Tirozin afinite kolon kromatografisi ile hCA I ve II izoenzimleri insan eritrositlerinden saflaştırıldı. Ardından IFNβ-1a ilacının hCA I, II izoenzimleri ve AChE, BChE enzimleri üzerine inhibisyon etkileri belirlenmiştir ve IC50 ve Ki değerleri hesaplanmıştır. Bu çalışmada hCA I izoenzimi için IC50 ve Ki değerleri sırasıyla 1.73 μM ve 0.78 ± 0.21μM olduğu bulunmuştur. Aynı parametreler hCA II izoenzimi için 1.33 μM ve 1.46 ± 0.13μM olduğu hesaplanmıştır. Enzim ile ilgili yapılan çalışmalarda IC50 ve Ki değerleri AChE enzimi için sırasıyla 13.86 μM ve 14.47 ± 4.81μM olduğu bulunmuştur. Enzim ile ilgili yapılan çalışmalarda son olarak IC50 ve Ki değerleri BChE enzimi için sırasıyla 18.72 μM ve 12.80± 4.38 μM olduğu bulunmuştur. Enzim ile ilgili yapılan çalışmalarda her iki CA izoenzimi için asetazolamit, AChE ve BChE enzimleri için ise Takrin standart olarak kullanılmıştır
PGPR İzolatlarının Bazı Fasulye Genotiplerinde Bitki Gelişimi Üzerine Etkisi
Authors: ANGIN Hilal , DADAŞOĞLU Esin
Published: November 2022

Bu araştırma sera koşullarında NPK ve bakteri uygulamalarının fasulye genotiplerinde (Hınıs ve İspir) bitki gelişimi üzerine etkilerini belirlemek amacıyla 2020-2021 yıllarında yürütülmüştür. Yürütülen denemede kontrol, NPK uygulaması ve 6 farklı Rhizobium sp. izolatı (FR-2, FR-4, FR-9, FR-19, FR-20, FR-22) yer almıştır. Araştırma her uygulamada 3 tekerrür olacak şekilde yürütülmüştür.
Elde edilen bulgulara göre fasulye bitkisinde bakteri uygulamasının bitki boyu, gövde çapı, bitki yaş ağırlığı, bitki kuru ağırlığı, kök yaş ağırlığı, kök kuru ağırlığı, kök uzunluğu, yaprak alanı, yaprak sayısı, nodül sayısı, gövde protein oranı ve toplam klorofil miktarını artırdığı tespit edilmiştir. Ancak klorofil miktarı ve kökteki protein miktarı üzerine NPK uygulamasının etkisinin daha iyi olduğu sonucuna varılmıştır. Genel olarak, çalışmada kullanılan farklı bakteri izolatlarının, ele alınan parametreler üzerine etkisinin NPK uygulamasına göre daha iyi olduğu sonucuna varılmıştır.
Farklı Sıcaklık Koşullarında Drosophila suzukii Matsumura 1931 (Diptera: Drosophilidae)’nin Gelişim Süreleri ile Tercih Ettiği Meyve Olgunluk Döneminin Belirlenmesi
Authors: ARIDICI KARA Dr. Pınar , ULUSOY Mehmet Rifat
Published: November 2022

Drosophila suzukii Matsumura 1931 (Diptera: Drosophilidae) yumuşak dokulu meyvelere zarar veren önemli bir karantina zararlısıdır. Hızlı yayılma gücüne sahip olan zararlı ile etkin mücadelenin temelini zararlının biyolojik özelliklerinin belirlenmesi oluşturmaktadır. Bu nedenle 2019 yılında ele alınan çalışmada D. suzukii’nin gelişme süreleri altı sabit (10, 15, 20, 25, 30 ve 35±1 °C), iki değişken (15/25 ve 25/35±1 °C) sıcaklık, %65±10 oransal nem ve 16:8 (Aydınlık: Karanlık) ışıklanma koşullarına sahip iklimlendirme odalarında belirlenmiştir. Aynı zamanda D. suzukii’nin tercih ettiği meyve olgunluk döneminin belirlenmesi çalışması da (25±1 °C) sabit sıcaklıkta %65±10 oransal nem ve 16:8 (Aydınlık: Karanlık) ışıklanma koşullarına sahip iklim dolabında yürütülmüştür. Çalışma sonucunda 10 °C’de 33-38, 15 °C’de 18-23, 20 °C’de 12-14, 25 °C’de 8-9 ve 15/25 °C’de 13-20 günde D. suzukii yumurtadan ergin hale gelirken, 30, 35 ve 25/35 °C sıcaklıklarda biyolojikbir gelişme görülmemiştir. Diğer taraftan D. suzukii’nin meyveyi tercih ettiği olgunluk dönemini belirlemek amacı ile kiraz meyvesinin yeşil/ sarı / kırmızı / koyu kırmızı gibi farklı fenolojik dönemlerinde tercihli ve tercihsiz olarak deneme kurulmuştur. Tercihli olarak kurulan denemede kırmızı meyve döneminde %60, koyu kırmızı meyve döneminde %90 oranında vuruk tespit edilirken, tercihsiz olarak kurulan denemede ise kırmızı meyve döneminde % 60 oranında, koyu kırmızı meyve döneminde %80 oranında vuruk tespit edilmiştir. Ayrıca her iki denemede de yeşil ve sarı dönemde vuruk gözlenmemiştir. Sonuç olarak D. suzukii gelişimini sıcaklık faktörünün etkilediği ve meyveyi kırmızı dönem ile koyu kırmızı dönemde tercih ettiği tespit edilmiştir.
Bazı Katkı Maddeleri Kullanımının Arap Ekmeğinin Kalitesine Etkisi
Authors: SATOUF Mustafa
Published: November 2022

Bu çalışmada 3 adet makarnalık buğday (Triticum durum) ve 3 adet ekmeklik buğday (Triticum aestivum) çeşidi kullanılarak elde edilen unlara sodyum steroil-2-laktilat (SSL), diasetil tartarik asidin monogliserid esteri (DATEM), C vitamini ve α-amilaz ilavesinin Arap ekmeğinin kalitesine etkisi araştırılmıştır. Çalışma kapsamında öncelikle buğday unlarının fiziksel, kimyasal ve reolojik özellikleri incelenmiştir. Değişik oran ve kombinasyonlarda (%0.25 SSL+α-amilaz, %0.25 DATEM+α-amilaz, %0.25 SSL+30 ppm C vitamini+α-amilaz ve %0.25 DATEM+30 ppm C vitamini+α-amilaz) katkı ilave edilen unlardan üretilen ekmek örneklerinde ise duyusal değerlendirmeler gerçekleştirilmiştir. Un örneklerinde kül, protein, gluten ve düşme sayısı değerleri sırasıyla %0.45-0.77, %10.40-12.10, %26.0-31.0, 398-491 saniye aralıklarında tespit edilmiştir. Farinograf analiz sonuçlarına göre su kaldırma oranı ortalama %68.40, gelişme süresi ortalama 3.50 dakika ve stabilite süresi ortalama 6.60 dakika olarak bulunmuştur. Ekstensograf analizinde ise 135. dakikadaki ortalama enerji değerleri makarnalık buğdaylarda ve ekmeklik buğdaylarda sırasıyla ortalama 51.00 cm2 ve 77.00 cm2 olarak bulunmuştur. Çalışma sonucunda %0.25 SSL+30ppm C vitamini+α-amilaz (D) ilave edildiğinde üretilen ekmeğin duyusal test sonuçlarının diğer katkılı ekmeklerden daha yüksek çıktığı tespit edilmiştir. Bu kombinasyonunu içeren makarnalık buğday unundan yapılan ekmek genel kabul edilebilirlik açısından 80.50 puan alırken, ekmeklik buğday unundan yapılan ekmek 93.30 puan almıştır.
Iğdır İli Hububat Ekim Alanlarındaki Eurygaster Laporte, 1832 Türleri (Hemiptera: Scutelleridae) ve Zarar Durumları Üzerine Araştırmalar
Authors: AÇIKGÖZ Mustafa , GÖZÜAÇIK Celalettin
Published: November 2022

Bu çalışma, 2015-2016 yıllarında Iğdır ili hububat ekiliş alanlarında Eurygaster (Laporte, 1832) (Hemiptera: Scutelleridae) türleri ve zarar durumlarını belirlemek amacıyla yürütülmüştür. Süne türlerinin belirlenmesinde nisan ve ağustos ayları arasında Aralık, Karakoyunlu, Merkez ve Tuzluca ilçelerinden 57 hububat tarlasından atrap yardımıyla toplanmıştır. Kışlamış ergin süneler (KES) ve nimf sayımları 24 buğday tarlasında her bir buğday tarlasının 12 farklı noktasında tesadüfi olarak ¼ m²’lik çerçeve kullanarak yapılmıştır. Emgi oranları (%) ise buğdayın hasat döneminde her tarladan toplanan ortalama ikişer kg başak alınarak belirlenmiştir. Buğday tarlalarındaki süne yoğunlukları, 2015 ve 2016 yıllarında sırasıyla ortalama 4.69 ve 2.97 nimf ve YNSE/m2 olarak belirlenmiş ve tanedeki ortalama emgi oranları ise %1.3 ve %1.1 olarak tespit edilmiştir. Ancak, Tuzluca ilçesinde dağ köylerinde yetiştirilen buğdayın sarı olum döneminde tarla çevresinden toplanan bireylerin her iki yılda da %3.7-7.7 oranlarında emgi oluşturduğu belirlenmiştir.
The forgotten threat of cholera in Syria
Authors: Al-Abdulla Orwa , Alaref Maher
Published: November 2022

Cholera is an ancient disease that persists as an issue of public health in many conflict-affected countries worldwide. Cholera is a diarrheal infection caused by ingested water or food contaminated with the bacterium Vibrio cholerae. On 10 September 2022, the Ministry of Health in Syria declared a cholera outbreak. Poor water and sanitation systems, disease surveillance breakdown, the collapse of the health system, and deteriorated socioeconomic conditions are potential risk factors for the outbreak's spread. Identifying the context-related factors associated with the spread of disease is a core to developing practical response mechanisms. In this study, we suggested a multisectoral approach that addresses context-specific elements contributing to the cholera outbreak spread in Syria; public health determinants, geopolitics, risk factors, and pandemic fatigue.
Improving the dependability of the servo drives of unmanned aerial vehicles through optimized operating modes
Authors: Korobeynikov I. S. , Vyrykhanov D. A. , Mityaev M. V.
Published: November 2022

Aim. Improving the reliability of servo drives through partial redundancy of structural components. Methods. The paper uses methods of harmonic analysis, technical system dependability theory. Results. The mean times to failure of servo drives that differ in terms of the level of redundancy of structural elements (external connectors, feedback sensors, control boards, electric motors and load gears) were compared. It was shown that structural element redundancy along with the capability to switch to still-operable elements in the course of servo drive operation enable a triple increase of the failure tolerance. The authors suggested criteria for identifying the moment of time for decision-making regarding an electric servo’s structure modification before the moment of failure of the redundant element of such servo. Conclusion. The method suggested in the paper allows formalizing the process of electric servo structure modification for the purpose of ensuring the required level of failure tolerance.
The phenomenon of trust as a factor of reliability in aviation
Authors: Krasilnikov G. T. , Krachko E. A. , Malchinsky F. V.
Published: November 2022

Aim. Based on an analysis of Russian and foreign literary sources, the paper deduces an estimation of the effect of trust in aviation on the safety and reliability of flights. Trust is a multifunctional phenomenon that appeared in the Russian scientific psychology relatively recently (in the mid-1990s) and soon became an object of research in many branches of science. The phenomenon of trust in scientific psychology is a high-complexity category due to its highly dynamic nature and multifactorial dependence. Objects of trust might include individuals, social groups and organisations, as well as various material and non-material phenomena. The phenomenon of trust is conventionally subdivided into self-trust, trust in people (social) and trust in the world. Methods. 49 specialised literary sources were analysed. Those include papers in science journals (25), papers in proceedings (8), monographs (15), abstracts of theses (1), out of which 37 are by Russian and 12 are by foreign authors. Results. The development of trust was traced through the ontogeny, its effect on personality development throughout life was identified. Of great importance is the basic trust that burgeons in the infancy within the mother – child diad ant later defines the view of life that significantly affects the socialization and personality development, behaviour in personal life and professional activities. The phenomenon of trust (cognitive, emotional, behavioural aspects), its phenomenology and psychosocial functions were analysed. It was established, that the phenomenon of trust is of significant importance in many spheres of life and activities of individuals and organisations. It is manifested in the ethical, psychosocial, economic, legal and political functions. The authors examine the applicability of the identified properties of trust in aviation. It was identified that the level of trust in aviation systems (civilian and military) affects flight safety. Of special importance is the trust in pilot operations, as it affects his/her adaptive capability in cases of professional emergencies. Conclusion. The paper substantiates the evaluation of the phenomenon of trust as a factor of reliability of an aviation system’s operation. At the same time, the effect of trust in the pilot on the adaptation and stress tolerance in emergency situations is identified. It is logical to consider personal trust of a pilot as a personal antistress resource. Consequently, the research should continue in order to identify the value of a pilot’ professional trust for the purpose of improving flight safety.
Evaluating the strength of a beam-type electric switch mechanism housing
Authors: Oganian E. S. , Chunin S. V. , Fazliakhmetov D. M. , Muravlev E. V. , Lobachev O. A.
Published: November 2022

Aim. Choice of method and its validation for the purpose of confirming the feasibility of safe operation of a switch mechanism housing submitted to rolling stock axle loads of 30 tf. Method. As of today, there are neither regulations regarding the strength parameters of load-carrying elements of electric switch mechanisms, nor verification procedures. Given the above, when evaluating the strength of electric switch mechanism housing, the authors used the method used for the purpose of evaluating the strength of load-carrying elements of locomotives per GOST R 55513-2013. That method has a long history of application as part of calculation and testing of motive power and has shown good results. According to the method, strength is evaluated by comparing the safety factor of fatigue strength n with the allowed value for steel structures [n] = 2.0. Result. The activities resulted in the validation of the proposed method of strength estimation by the criterion of fatigue strength. The value of fatigue endurance of electric switch mechanism housing was estimated based on the results of fatigue benchmark tests of three items. Each was stressed by stepping up the amplitude of the applied force after the base number of cycles had been reached. At the first stage, the loading was equivalent to the operational value. After the base number of functions had been reached for each item, the following step was initiated. The tests continued until cracks have been found. In the process of testing, the amplitude of stress was recorded at each level of loading. For the purpose of identifying the fatigue strength characteristics, the reduced fatigue strength of the switch mechanism housing was calculated under the hypothesis of linear addition of fatigue damage subject to the condition of deterministic loading and subsequent processing of the findings using statistical methods. The value of fatigue limit has been obtained for the housing of a tie-type electric switch mechanism equal to 48.4 MPa. The safety factor of fatigue strength was found to be equal to 2.86, which is above the minimal allowed value. Conclusion. It has been shown that the housing of a tie-type electric switch mechanism has a sufficient strength as regards the operational static and dynamic loads. Its safe operation when exposed to axle loads of 30 tf has also been confirmed.
Evaluating the economic efficiency of preventive measures aimed at reducing the number of train control violations
Authors: Kulagin M. A. , Sidorenko V. G.
Published: November 2022

Aim. The paper aims to examine the matters related to increasing the objectivity of evaluation of the quality of train control by train drivers. Methods. The study presented in the paper uses statistical analysis and linear algebra. Results. An algorithm was developed for defining preventive measures and their application efficiency was evaluated for drivers of rapid transit trains. The algorithm for defining preventive measures for drivers of rapid transit trains includes the following: violation prediction; definition of the factors that affect the onset of each type of violations; definition of the characteristics of the drivers that most deviate from the target values. The efficiency estimation is based on the assumption of correlation between the cost of a driving instructor’s work with a driver and the cost of losses that the company might incur in case of violations. The paper shows that the level of an error of the first kind in the train driver violation prediction model is justified, provided that the cost incurred as the result of gross train control violations is significantly greater than that associated with the training of such driver. The paper presents an analysis of the application of the AI-based system in four depots. Conclusion. The paper presents an algorithm for defining preventive measures for train drivers. An economic criterion was defined for evaluating the efficiency of application of the developed mathematical model for predicting gross violations of train control. The required and sufficient conditions of economic efficiency of the AI-based systems application were analysed. A comparative analysis was presented of the mean number of gross train driving violations in depots with and without the AI-based system.
Analysis of UMAP, the method for reducing the dimensionality of initial data in machine learning for the purpose of failure prediction in a motive power service
Authors: Pronevich O. B. , Klokova A. P.
Published: November 2022

Aim.Feature transformation is one of the stages of machine learning applicationthat has a significant effect on the quality of regression models. The paper aims to developcriteria for evaluating the quality of data dimensionality reduction at the stage of featuretransformation and adaptation of the UMAP method to the problem of prediction of the numberof days to failure in the locomotives of JSC RZD.Methods.The data transformation methodsare divided into two groups, those that attempt to preserve the global data structure, andthose that attempt to preserve the distances between points. The paper examines in detail theUMAP no-linear method of dimensionality reduction, whose low-dimensional data presentationis based on a transformation of a nearest neighbour graph retaining the data structure. Thestructure of the initial data manifold is examined using topological data analysis and simplifiedfuzzy set construction methods.Results.The analysis of UMAP theory conducted in theRussian language for the first time enabled a substantiated identification of the three primaryparameters of the method, whose variation significantly affects the type of data obtained asthe result of a transformation. In particular, that pertains to the quality of class separationover a two-dimensional space. Additionally, the characteristics of the input set of parameterswere identified that affect the UMAP results. Practical results of UMAP application weredemonstrated. Intermediate results included a list of nearest neighbours, a weighted graph of nearest neighbours. The fundamental result is a low-dimensional data representation (outof 44 initial measurements) over a two-dimensional space with class separation, which isconfirmed both by calculations, and visually.Conclusions.It was identified that UMAP is anefficient and substantiated method of dimensionality reduction that allows – through parametervariation – transforming data in such a way as to improve the quality of data submitted tomachine learning models by the criterion of “evident class separation”. The transformation is anintermediate stage of data preparation for regression model application, and class separationwas performed for the purpose of eliminating the probability of gross regression errors.
Projektowane zadania koordynatora ds. specjalnych potrzeb edukacyjnych w polskim systemie edukacji w kontekście brytyjskich doświadczeń SENCo
Authors: Gajdzica Zenon
Published: November 2022

Jednym z elementów szerokiego wachlarza rozwiązań służących podnoszeniu jakości edukacji włączającej są koordynatorzy określani mianem SENCo (Special Educational Needs Coordinators), którzy w wielu krajach odgrywają istotną rolę w kreowaniu, wspieraniu i koordynowaniu edukacji włączającej w przestrzeni szkoły ogólnodostępnej. Stanowisko Koordynatora ds. Specjalnych Potrzeb Edukacyjnych jak dotąd nie zostało usankcjonowane prawnie w naszym kraju. Niemniej jednak jego propozycja – pod nazwą KEW (Koordynator Edukacji Włączającej) – pojawiła się w dwóch dokumentach opracowanych w zespołach pod auspicjami MEN w 2020. Zdawkowe przywołanie KEW znajdujemy w opracowaniu pt. Wspieranie podnoszenia jakości edukacji włączającej w Polsce (2020), a znacznie obszerniejsze informacje, z dokładnym uwzględnieniem jego zadań, zostały sformułowane w projekcie zatytułowanym Model edukacji dla wszystkich (2020). Celem opracowania jest konfrontacja przywołanej w Modelu edukacji dla wszystkich propozycji zadań KEW z informacjami na temat roli SENCo jaką odgrywa on w angielskim systemie kształcenia, ze szczególnym uwzględnieniem projektowanych dla niego zadań oraz trudności związanych z ich realizacją. W pierwszej części artykułu odniosę się ogólnie do obecnego stanu edukacji włączającej w Polsce, w kolejnej zaprezentuję podstawowe informacje na temat roli i zadań koordynatorów zaczerpnięte z doświadczeń innych krajów, ze szczególnym uwzględnieniem brytyjskiego modelu. Meritum opracowania stanowi analiza propozycji roli i zadań KEW zawarta w Modelu edukacji dla wszystkich (2020). Całość zamkną konkluzje końcowe.