bluuebunny/crossref_metadata_2025 huggingface dataset:
Conflictos Fundamentales en Materia de Custodia Compartida: Contribución de los Progenitores al Sostenimiento de los Hijos y Atribución de la Vivienda Familiar
Authors: Vázquez Marta Madriñán
Published: February 2019

La Ley 15/2005, de 8 de julio vino a introducir de forma expresa en nuestro Derecho civil el régimen de guarda y custodia compartida con la finalidad de evitar que, tras la ruptura de la pareja, los hijos dejen de tener una relación fluida con sus progenitores. La guarda y custodia compartida incide de manera importante en los pronunciamientos económicos de las sentencias, y en concreto en lo relativo a la pensión de alimentos y la atribución del uso de la vivienda familiar. Ante el silencio del legislador, ha sido la jurisprudencia del Tribunal Supremo la que ha ido perfilando y a través de su interpretación, las ha ido adecuando al régimen de custodia compartida.
Direito da Integração-Direito Interno: uma Interpretação Teleológica/Axiológica Rumo ao Direito Comunitário no Mercosul
Authors: Preti Ricardo Delgado
Published: February 2019

O presente estudo tem como objetivo demonstrar os avanços do direito comunitário no Mercosul e apresentar um novo método de solução das antinomias do direito interno e internacional, baseado no diálogo de complementariedade entre as normas internas dos países membros do bloco regional Mercosul. Como parte de uma interpretação teleológica do direito, frente ao culturalismo jurídico e o novo fenômeno do internacionalismo que vivemos, buscamos também estudar como esta cooperação é possível. A dissertação do presente estudo está estruturada sobre uma hipótese normativa (numa visão do culturalismo jurídico), explicativa e interpretativa (teleológica e axiológica) dos tratados internacionais, com suporte nos ensinamentos dos doutrinadores Rodolfo Luis Vigo, Valerio Mazzuoli de Oliveira, Hildebrando Accioly, dentre outros, os quais defendem o status supraconstitucional dos tratados internacionais, especialmente os voltados para defesa da personalidade da pessoa, não sendo esta uma novidade no mundo da opinio doctorum, além da análise de casos julgados pela Corte Europeia e das Supremas Cortes dos países quem compõe o Mercosul. Destaca-se que a comunidade europeia é o bloco regional que teve melhor êxito neste aspecto de complementariedade entre normas internacionais com as normas internas. O Mercosul também passa a conviver com esta nova onda do direito, porém, pouco difundida ou estudada no mundo acadêmico. É necessário garantir o cumprimento dos tratados de integração frente ao dever de respeito ao princípio da boa-fé dos compromissos firmados no plano internacional, como exige a Convenção de Viena. O processo de cooperação da União Europeia deve-se, em larga medida, não só à existência do controle jurisdicional supranacional exercido pelo Tribunal de Justiça como também à compreensão dos tribunais internos à medida que passaram a compreender que as normas internas e internacionais devem dialogar. Ao final deste estudo, desmistificaremos que a integração necessariamente impõe uma reforma constitucional, quando a mutação constitucional já permite alcançá-lo, cabendo ao poder judiciário exercer valioso instrumento na construção do direito. Compreendemos, ainda, que as normas derivadas do Mercosul têm sua aplicabilidade, eficácia e plena vigência por aplicação teleológica das constituições de seus Estados-membros.
INFLUENCE OF CHEMICAL SURFACE MODIFICATION ON MICRO-WEAR CHARACTERISTICS OF SUGARCANE NANOCELLULOSE EPOXY NANOCOMPOSITES
Authors:   Department of Mechanical Engineering, National Institute of Technology, Tiruchirappalli, India, H Mohit , Selvan Arul Mozhi ,   Department of Mechanical Engineering, National Institute of Technology, Tiruchirappalli, India
Published: February 2019

The waste sugarcane bagasse is the primary agricultural biomass of sugarcane industry and its main constituents is cellulose. These waste sugarcane bagasse can also be applied as reinforcement material in polymer matrix composites. In this present work, the nanocellulose fibers extracted from sugarcane bagasse using salt solution and alkaline treatment process. Sugarcane nanocellulose fiber reinforced epoxy nanocomposites were manufactured by wet layup method. This investigation has been conducted to exhibit the utilization of plant cellulose fiber as the potential reinforcement of synthetic fibers in tribo-composites. The dry sliding wear experiments designed and carried out as per central composite design to determine influence of 3 variable factors such as sliding velocity, sliding distance and load on the wear characteristics of epoxy nanocomposites. From ANOVA (Analysis of variance), it is observed that all three independent parameters plays an important role in the wear characteristics of epoxy nanocomposites, as proven from scanning electron microscope. Simultaneously minimize these tribological characteristics, desirable values of the parameters were depicted to be 5.94 m/s, 5 km and 5 N for sliding velocity, distance and load respectively. From normal probability curves, it is signified that there is a good agreement within the RSM models and experimental results.
El clima organizacional en el emprendimiento sostenible
Authors: Chirinos Araque Yamarú Del Valle , Meriño Córdoba Víctor Hugo , Martínez de Meriño Carmen
Published: February 2019

El estudio tiene como objetivo analizar el clima organizacional en el emprendimiento sostenible, con el fin de identificar la influencia del ambiente laboral en el desarrollo del emprendimiento y en el éxito del mismo, donde se hace énfasis en la importancia que tiene para la interacción entre las personas. Se consideró los enfoques de Drucker (2011), Chirinos & Pérez (2016), Alcóver, Rico & Gil (2011), entre otros. La investigación fue orientada desde el paradigma cuantitativo, el tipo de investigación fue descriptiva, transaccional de campo. Los resultados obtenidos indican que el clima organizacional es bajo, incidiendo negativamente en el desarrollo del emprendimiento sostenible, en conclusión, los empleados se sienten insatisfecho con el clima organizacional en su área laboral.
Towards the construction of a mechanism supported in fuzzy logic to evaluate the viability of businesses under the canvas model
Authors: Acosta Contreras Laura Daniela , Barreto López Andrés Ricardo , Montenegro Marín Carlos Enrique , Gaona García Paulo Alonso
Published: February 2019

Rev.esc.adm.neg

This article aims at showing the first functional approximation to the creation of a mechanism which generates a viability indicator of of a producto r a business plan base don the design of Canvas Model as well as using Emis Benchmarking Score as a referential issue suggested by Euromoney Institutional Inversor Company (EMIS), an organization which reveals company financial information. This approximation focuses on the application of fuzzy logic as a tool for analyzing and generating this indicator.Based on the data and information generated by a fuzzy stated system and experimental figures, a Pearson correlation coefficient was used to measure this behavioral model, resulting in 88 % which
Wettability Alteration of Carbonate Reservoir Cores—Laboratory Evaluation Using Complementary Techniques
Authors: Khaleel Omar , Teklu Tadesse W. , Alameri Waleed , Abass Hazim , Kazemi Hossein
Published: February 2019

The objective of this paper was to assess the applicability of relatively low-salinity brine and different surfactants for enhanced oil recovery (EOR) in carbonate reservoirs in the Middle East. Phase behavior, interfacial tension (IFT), contact angle, spontaneous imbibition, and ζ-potential experiments were performed.

The experimental work flow included a phase-behavior study followed by IFT, contact-angle measurements, spontaneous-imbibition measurements, and ζ-potential measurements at varying salinities and surfactant concentrations.

Contact-angle-measurement results indicated that surfactant solutions, in addition to lowering IFT, tend to change the core wettability from oil-wet or neutral-wet to more water-wet. Furthermore, the best results were achieved by adding an anionic surfactant. Moreover, spontaneous imbibition and ζ-potential measurements provided additional supporting data that diluted seawater (DSW), in a dilute anionic or nonionic surfactant solution, alters the wettability of carbonates to a favorable wetting state for improving oil recovery.

This research presents a set of diverse experimental data that confirms adding low concentrations of anionic and nonionic surfactants to DSW improves oil recovery from carbonate reservoirs.
Opportunities for selective reporting of harms in randomized clinical trials: Selection criteria for nonsystematic adverse events
Authors: Mayo-Wilson Evan , Fusco Nicole , Hong Hwanhee , Li Tianjing , Canner Joseph K. , Dickersin Kay
Published: February 2019

Background: Adverse events (AEs) in randomized clinical trials may be reported in multiple sources. Different methods for reporting adverse events across trials, or across sources for a single trial, may produce inconsistent and confusing information about the adverse events associated with interventions
Methods: We sought to compare the methods authors use to decide which AEs to include in a particular source (i.e., “selection criteria”) and to determine how selection criteria could impact the AEs reported.
We compared sources (e.g., journal articles, clinical study reports [CSRs]) of trials for two drug-indications: gabapentin for neuropathic pain and quetiapine for bipolar depression. We identified selection criteria and assessed how criteria affected AE reporting.
Results: We identified 21 gabapentin trials and 7 quetiapine trials. All CSRs (6 gabapentin, 2 quetiapine) reported all AEs without applying selection criteria; by comparison, no other source reported all AEs, and 15/68 (22%) gabapentin sources and 19/48 (40%) quetiapine sources reported using selection criteria. Selection criteria greatly affected the number of AEs that would be reported. For example, 67/316 (21%) AEs in one quetiapine trial met the criterion “occurring in ≥2% of participants in any treatment group,” while only 5/316 (2%) AEs met the criterion, “occurring in ≥10% of quetiapine-treated patients and twice as frequent in the quetiapine group as the placebo group.”
Conclusions: Selection criteria for reporting AEs vary across trials and across sources for individual trials. If investigators do not pre-specify selection criteria, they might “cherry-pick” AEs based on study results. Even if investigators pre-specify selection criteria, selective reporting of AEs will produce biased meta-analyses and clinical practice guidelines. Data about all AEs identified in clinical trials should be publicly available; however, sharing data will not solve all the problems we identified in this study.
Keywords: Harms, adverse events, clinical trials, reporting bias, selective outcome reporting, data sharing, trial registration
In vitro examination of the thrombolytic efficacy of tenecteplase and therapeutic ultrasound compared to rt-PA
Authors: Frühwald Tobias , Gärtner Ulrich , Stöckmann Nils , Marxsen Jan-Henning ,   Carolin Gramsch4, Roessler Florian Carolus
Published: February 2019

Background: Optimizing thrombolytic therapy is vital for improving stroke outcomes. We aimed to evaluate the efficacy of tenecteplase (TNK) compared to the current gold standard rt-PA (alteplase), with and without additional ultrasound treatment.
Methods: In vitro clots that are similar to ex vivo clots concerning their histological condition and their durability were generated from whole blood. For five treatment groups we compared relative clot weight loss (each n=60) and fibrin fiber density in transmission electron microscopy (TEM) (each n=5). The control group (A) was treated only with plasma. Two groups were designated for each rt-PA (B+C) and TNK (D+E). Groups C and E were additionally treated with ultrasound. Dosages were 50µg/ml for rt-PA and 30µg/ml for TNK. Results were evaluated by using analyses of variance (ANOVA) and post-hoc t-tests.
Results: Weight loss was increased significantly for all groups compared to the control group. Both TNK groups showed significantly increased weight loss compared to their counterpart rt-PA group (p≤0.001). For TEM only group D showed significantly decreased fibrin fiber density (p<0.05) compared to both rt-PA groups. Ultrasound did not significantly increase dissolution of clots with either method (best p=0.16).
Conclusions: Tenecteplase dissolved clots more effectively than rt-PA with and without ultrasound. A higher sample size could provide more convincing results for TEM.
Keywords: Stroke, thrombolysis, tenecteplase, ultrasound, transmission electron microscopy.
Anti-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor GluR2 encephalitis in a myasthenia gravis patient with complete thymectomy: a case report
Authors: Luo Qingyang , Wu Xianghong , Huang Wen
Published: February 2019

Background: Autoimmune encephalitis (AE) is a newly recognized autoimmune disorders in which the targets are proteins or receptors involved in synaptic transmission and neuronal excitability. α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) is a subtype of glutamate receptor that mediates most of the fast excitatory neurotransmission in the brain.
Case presentation: A 50-year-old woman presented with subacute onset of memory loss and behavioral changes. High levels of serum (1:1000) and CSF (1:32) antibodies against the AMPAR GluR2 were detected. A wide range of abnormalities in 6-8 Hz low to middle slow waves was found by electroencephalographs, and high-intensity signals on fluid-attenuated inversion recovery in both the medial temporal lobe and hippocampus were identified on brain magnetic resonance images. This patient presented with myasthenia gravis and type B2 thymoma (World Health Organization Thymoma Classification) at age 48. This case was unique in that the patient initiated with the symptom of myasthenia gravis and thymoma two years prior to encephalitis, and a complete thymectomy was performed before AE onset without recurrence of the thymoma when encephalitis occurred.
Conclusions: Thymoma was reported to be associated with paraneoplastic neurological disease. This is the first time a thymectomy has been applied in a myasthenia gravis patient with thymoma two years prior to the onset of anti-AMPAR2 encephalitis. This case highlights the complexity of autoimmune encephalitis associated with thymoma.
Keywords: Autoimmune encephalitis, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor, thymoma, myasthenia gravis.
Sleep disturbance subtypes in Parkinson’s disease based on the cross-culturally validated Korean version of the Parkinson’s Disease Sleep Scale-2
Authors: Yang Hui-Jun , Kim Han-Joon , Koh Seong-Beom , Kim Joong-Seok , Ahn Tae-Beom , Cheon Sang-Myung , Cho Jin Whan , Kim Yoon-Joong , Ma Hyeo-Il , Park Mee-Young , Baik Jong Sam , Lee Phil Hyu , Chung Sun Ju , Kim Jong-Min , Song In-Uk , Kim Ji-Young , Sung Young-Hee , Kwon Do Young , Lee Jae-Hyeok , Lee Jee-Young , Kim Ji Sun , Yun Ji Young , Kim Hee Jin , Hong Jin Young , Kim Mi-Jung , Youn Jinyoung , Kim Ji Seon , Oh Eung Seok , Yoon Won Tae , You Sooyeoun , Kwon Kyum-Yil , Park Hyung-Eun , Lee Su-Yun , Kim Younsoo , Kim Hee-Tae , Kim Sang Jin
Published: February 2019

Background: Sleep-related problems in Parkinson’s disease (PD) have received greater attention in recent years due to their clinical influence on morbidity, disability, and the health-related quality of life (HRQoL) of patients. This study aimed to evaluate the clinimetric properties of the Korean version of the Parkinson’s Disease Sleep Scale-2 (K-PDSS-2), and to analyze whether distinct sleep disturbance subtypes could be empirically identified in patients with PD based on the cross-culturally validated K-PDSS-2.
Methods: The internal consistency, test-retest reliability, scale precision, and convergent validity of the K-PDSS-2 were assessed in a nationwide, multicenter study of 122 patients with PD. Latent class analysis (LCA) was used to derive subgroups of patients who experienced similar patterns of sleep-related problems and nocturnal disabilities.
Results: The mean total K-PDSS-2 scores were 11.67 ± 9.87 (mean ± standard deviation) at baseline, and 12.61 ± 11.17 upon follow up testing. The Cronbach’s α coefficients of the total K-PDSS-2 score at baseline and at follow up testing were 0.851 and 0.880 respectively. Intraclass correlation coefficient over the 2-week period ranged from 0.672 to 0.848. The total K-PDSS-2 score was strongly correlated to HRQoL measures and other corresponding nonmotor scales. LCA indicated three distinct sleep disturbance classes in the study patients, namely “less troubled sleepers”, “PD-related nocturnal difficulties”, and “disturbed sleepers”.
Conclusions: The K-PDSS-2 showed good clinimetric attributes in accordance with prior studies that were using the original version of the PDSS-2, therefore confirming the cross-cultural usefulness of the scale. Further, this study documents the first application of an LCA approach for identifying sleep disturbance subtypes in patients with PD.
Keywords: Parkinson’s disease; sleep; PDSS-2; validity; reliability; Korean version; latent class analysis.
Superconductivity in the Hubbard model: a hidden-order diagnostics from the Luther-Emery phase on ladders
Authors: Tocchio Luca Fausto , Becca Federico , Montorsi Arianna
Published: February 2019

Short-range antiferromagnetic correlations are known to open a spin
gap in the repulsive Hubbard model on ladders with
\boldsymbol{M}𝐌
legs, when \boldsymbol{M}𝐌
is even. We show that the spin gap originates from the formation of
correlated pairs of electrons with opposite spin, captured by the hidden
ordering of a spin-parity operator. Since both spin gap and parity
vanish in the two-dimensional limit, we introduce the fractional
generalization of spin parity and prove that it remains finite in the
thermodynamic limit. Our results are based upon variational wave
functions and Monte Carlo calculations: performing a finite size-scaling
analysis with growing \boldsymbol{M}𝐌,
we show that the doping region where the parity is finite coincides with
the range in which superconductivity is observed in two spatial
dimensions. Our observations support the idea that superconductivity
emerges out of spin gapped phases on ladders, driven by a spin-pairing
mechanism, in which the ordering is conveniently captured by the
finiteness of the fractional spin-parity operator.
İşitme Kayıplı Çocuğu Olan Bir Annenin Aile Eğitimi Sürecinin İncelenmesi
Authors: TURAN Zerrin , KOCA Aslı , UZUNER Yıdız
Published: February 2019

Bu
araştırmanın amacı işitme kayıplı çocuğu olan bir annenin, aile eğitimi
sürecinin incelenmesidir. Eylem araştırması olarak desenlenen çalışmanın
katılımcıları işitme kayıplı bir çocuğun annesi ve eğitimcidir. Araştırma
verileri, aile eğitimi uygulamalarının videoteyp kayıtları, anneyle yapılan
görüşmeler, geçerlik güvenirlik komitesi ses kayıtları ve araştırmacı
günlükleri yoluyla toplanmıştır. Araştırma sürecinde toplam on seans aile
eğitimi yapılmıştır. Aile eğitimi sürecinin incelenmesi amacıyla tüm seansların
genel dökümü yapılmış, elde edilen verilere tümevarım analizi uygulanmıştır.
Araştırma süresince her seans sonrası yazarlar arasında düzenlenen
toplantılarla seans süresince karşılaşılan sorunlar saptanmış ve yeni bir eylem
planı oluşturulmuştur. Oluşturulan eylem planı çerçevesinde bir sonraki aile
eğitimi planlanarak uygulanmıştır. Çalışma süresince bu döngü sistematik bir
şekilde sürdürülmüştür. Verilerin analizi sonucu 7 ana  tema, 9 alt temaya ulaşılmıştır. On seans eğitim
sonrasında annenin çocuğun gelişimini destekleyen olumlu davranışlarında artış
ve eğitimcinin aile eğitimi uygulamasında olumlu değişikler gözlenmiştir.
A Study Of Indian Private And Public Sector Banks With Special Reference To Impact Of Post Merger And Acquisition Venture On Liquidity And Profitability
Authors: Gogia. Prof.(Dr.) Neeraj
Published: February 2019

This study was directed to assess the impact of merger and acquisition activities on the performance of Banks in India. The paper reviews the trends in M and A’s in Indian banking and then impact of M and A’s has been studied. The study
covers the area of performance evaluation of M and A’s in Indian banking sector during the period pre and post period of six years of Merger and Acquisition activity. The paper studied the post merger financial performance of merged banks with the
help of financial parameters. The study recommended that policies and strategies instituted by management, for instance the credit policy, should be re-visited in order to enhance internal and external operations, the logistical framework support
should be improved; a more comprehensive approach to integrated marketing communications mix should be put in place in the promotion of the Bank’s existing and added products so as to gain more market share.
Komitmen Organisasi pada Dosen Generasi Milenial
Authors: Sari Reza Lidia
Published: February 2019

In Human Resource Management, workers from the millennial generation, including those working as lecturers in Indonesia, are often studied with regard to their low level of organizational commitment. Millennial lecturers are often faced with various challenges that can trigger them to decide to quit their jobs and leave the college. This research aimed to discover the factors influencing millennial lecturers’ organizational commitment. The instruments used were the Organizational Commit­ment Scale, Job Satisfaction Survey, and Professional Commitment Scale. The respondents were 123 lecturers from 10 universities in Padang, Jakarta, and Bali, who were selected using purposive sampling technique. The analysis method used was a multiple regression analysis. The research findings showed that job satisfaction and professional commitment, to be exact, their satisfaction with supervisors, professional commitment continuance and normative professional commitment had a significant impact on these lecturers’ organizational commitment. The result of this study delivers important implications to universities in managing their millennial lecturers so that they can improve their organizational commitment.

 

 
Formula and Technology Development for Obtaining Biologically Active Natural Food Additives
Authors: Смирнов Станислав , Smirnov Stanislav , Фазуллина Олия , Fazullina Oliya
Published: February 2019

The research featured the development of formulae and technologies for the production of biologically active additives (BAA) for functional foods with potential adaptogenic, antioxidant, and hepatoprotective properties. Shilajit, a natural mineral-organic substrate, and various plant materials were used as sources of natural biologically active substances (BAS). The relevance of the study comes from the need for more efficient use of natural biologically active compounds, as well as from the need to expand the range of domestic dietary supplements with natural ingredients, which resulted from the current import substitution. Scientific data and experimental studies made it possible to choose advantageous raw materials with BAS and to assess their safety and potential properties. An experiment determined the content of BAS in the raw materials and in the control samples. A compatibility test wasconducted by mixing. As a result, five formulae with various combinations of natural components in the composition were scientifically substantiated. The authors defined the physicochemical and technological properties of the mixtures of dry extracts that determined the choice of technology and the quality of the finished product. The present paper also describes technology of obtaining encapsulated dietary supplements based on dry extracts of medicinal plants and shilajit. The advantage of the technology lies in the use of natural components and special processing methods of BAS preservation. The research included the method of water-activated granulation while 20% ethyl was used as a wetting agent. To obtain the granulate, lactose (Russia) and AEROSIL® 200 Pharma (Evonik Industries, Germany) were used as additive agents. As a result, capsules with a dosage of 700 mg were developed. The BAA can be produced on food and pharmaceutical plants.
Influence of Various Technological Factors on the Composition of Anthocyanins in Black Currant Wine Production
Authors: Макаров Сергей , Makarov Sergey , Макаров Сергей , Makarov Sergey , Панасюк Александр , Panasyuk Alexander
Published: February 2019

Anthocyanins obtained from raw fruit have valuable biological and antioxidant properties, hence the relevance of any research aimed at the development of technological solutions for their maximum preservation in wine. The present research features the changes in qualitative and quantitative composition of anthocyanins found in black currant during wine production with the use of enzymatic maceration of the pulp. The authors determined the most effective ways of increasing the concentration of anthocyanins in the finished product. They used the method of pH-differential spectrophotometry to evaluate the total content of monomeric anthocyanins in the samples and the HPLC method to determine the concentration of individual anthocyanins. The DPPH and ABTS methods were used to measure the antioxidant activity. The pulp of black currant was treated according to four schemes: 1) heat maceration; 2) heat maceration with enzymatic treatment; 3) enzymatic maceration at the optimum temperature for enzyme activity; 4) enzymatic maceration at a low temperature. Eleven anthocyanins were identified in the black currant juice, most of which were glycosides of delphinidin and cyanidin. The highest extraction of anthocyanins was observed when the pulp was processed with the help of Fructozim Kolor enzyme preparation at 22–23°C during four hours. As a result, the proportion of delphinidins decreased while the proportion of cianidins rose by 9%. When the pulp was heated to ≥ 45°C, it led to an intensification of the redox process and formation of insoluble complexes of anthocyanins with the nitrogenous compounds, which reduced the total concentration of anthocyanins. It was established that in the process of fermentation, the anthocyanin concentration decreased by 19–58%, depending on the race of yeast. For fermentation of blackcurrant wort, the authors recommend the following races of yeast: Moscow 30, Blackcurrant 7, and UWY SP1. The research revealed that the antioxidant properties of black currant wort and wine increased when the total concentration of anthocyanins was high.
Yedioluk-Kozan (Adıyaman) Bölgesi İçme Sularının Karakteristiklerinin Hidrojeolojik Açıdan İncelenmesi
Authors: URAS Yusuf , UYSAL Yağmur , YILMAZ Mehmet Nihat , PAKSOY Merve
Published: February 2019

Bu çalışmanın amacı, Adıyaman ili sınırları içerisinde yer alan Yedioluk ve Kozan bölgesindeki içme suyu kaynaklarının hidrojeokimya, izotop jeokimyası ve tıbbi jeoloji yönünden araştırılmasıdır. Adıyaman merkezinin kuzeydoğusunda önemli bir su potansiyeline sahip olan bölgede 8 adet içme suyu kaynağı yer alır. Üst Jura-Alt Kretase yaşlı Koçali Kompleksi ana akifer niteliğinde olup Yedioluk ve Kozan bölgelerinde içme suyu kaynaklarının önemli bir bölümü bu akiferden boşalır. Bölgeden bir yıl boyunca farklı mevsimlerde (yağışlı/kurak dönemlerde) alınan su örneklerinde δ18O(Oksijen)- δ2H(Döteryum) ve (Trityum) analizleri yapılmıştır. Kaynakların su kalitesini belirlemek amacıyla,  sıcaklık, pH, iletkenlik, alkalinite, iz element derişimleri, anyon-katyon ölçümleri ve metal derişimleri, iyon kromatografisi (IC) ve ICP-OES kullanılarak gerçekleştirilmiştir. İzotop analizlerinden faydalanılarak suların kökenine ait bilgilere ulaşılmış, elde edilen sonuçlar, incelenen su kaynaklarının soğuk sular sınıfında olduğunu göstermiştir. Ayrıca, bölgedeki su kaynaklarının çoğunda yüksek miktarda nitrat iyonu derişimine rastlandığı, bu su kaynaklarının içme suyu kaynağı olarak kullanılmadan önce arıtımdan geçirilmesi sonucuna ulaşılmıştır. 
Dynamic Modeling of Slider-Crank Mechanism for Selecting Input Parameters for Desired Piston Speeds: Lumped Mass Approach
Authors: SARIGEÇİLİ Mehmet İlteriş , AKÇALI İbrahim Deniz
Published: February 2019

Here the dynamic behavior of slider-crank mechanism with a driving force applied at crank-pin center, has been modeled to formulate the piston speed.  In view of the abundance of the parameters involved, a lumped parameter approach has been preferred to obtain a compact equation in the form of a second order nonlinear differential equation. The complexity of the resulting equation has mandated implementing a numerical solution technique by which the effects of the selected parameters on the piston speed have been investigated. Under similar conditions an experimental model has been prepared and the tests have been carried out to compare the results. Low error levels achieved in two results have demonstrated the validity of the developed model.  
Nutritional composition, Taxonomical and phytoremediation status of Duckweed (Wolffia): Review
Authors: Pandey Amit , R.K. Verma
Published: February 2019

Wolffia are the crucial in decline of a flowering plant having tiny, rootless spheres in 1 mm length (or less). Wolffia is commonly known as Watermeal because it look like small particles over the water. 5 species of Wolffia are found in Western United States, while 11 species all over world. Being taken from pond to pond on the feet of water fowl (tucked neatly under the ducks' bodies during flight), might describe the distribution of few Wolffia species. In the South eastern part of US, there are evidence of Wolffia plant being taken from tornado, and they had been reported in the water of melted hailstones. Our review were focus on the Nutritional aspects, Taxonomy, Phytoremediation of heavy metal and uses of different species of Wolffia plant.
Clinicians’ Role in the Adoption of an Oncology Decision Support App in Europe and Its Implications for Organizational Practices: Qualitative Case Study (Preprint)
Authors: Jacob Christine , Sanchez-Vazquez Antonio , Ivory Chris
Published: February 2019

BACKGROUND

Despite the existence of adequate technological infrastructure and clearer policies, there are situations where users, mainly physicians, resist mobile health (mHealth) solutions. This is of particular concern, bearing in mind that several studies, both in developed and developing countries, showed that clinicians’ adoption is the most influential factor in such solutions’ success.

OBJECTIVE

The aim of this study was to focus on understanding clinicians’ roles in the adoption of an oncology decision support app, the factors impacting this adoption, and its implications for organizational and social practices.

METHODS

A qualitative case study of a decision support app in oncology, called ONCOassist, was conducted. The data were collected through 17 in-depth interviews with clinicians and nurses in the United Kingdom, Ireland, France, Italy, Spain, and Portugal.

RESULTS

This case demonstrates the affordances and constraints of mHealth technology at the workplace, its implications for the organization of work, and clinicians’ role in its constant development and adoption. The research findings confirmed that factors such as app operation and stability, ease of use, usefulness, cost, and portability play a major role in the adoption decision; however, other social factors such as endorsement, neutrality of the content, attitude toward technology, existing workload, and internal organizational politics are also reported as key determinants of clinicians’ adoption. Interoperability and cultural views of mobile usage at work are the key workflow disadvantages, whereas higher efficiency and performance, sharpened practice, and location flexibility are the main workflow advantages.

CONCLUSIONS

Several organizational implications emerged, suggesting the need for some actions such as fostering a work culture that embraces new technologies and the creation of new digital roles for clinicians both on the hospitals or clinics and on the development sides but also more collaboration between health care organizations and digital health providers to enable electronic medical record integration and solving of any interoperability issues. From a theoretical perspective, we also suggest the addition of a fourth step to Leonardi’s methodological guidance that accounts for user engagement; embedding the users in the continuous design and development processes ensures the understanding of user-specific affordances that can then be made more obvious to other users and increase the potential of such tools to go beyond their technological features and have a higher impact on workflow and the organizing process.
Feasibility of a Real-Time Clinical Augmented Reality and Artificial Intelligence Framework for Pain Detection and Localization From the Brain (Preprint)
Authors: Hu Xiao-Su , Nascimento Thiago D. , Bender Mary C , Hall Theodore , Petty Sean , O’Malley Stephanie , Ellwood Roger P , Kaciroti Niko , Maslowski Eric , DaSilva Alexandre F
Published: February 2019

BACKGROUND

For many years, clinicians have been seeking for objective pain assessment solutions via neuroimaging techniques, focusing on the brain to detect human pain. Unfortunately, most of those techniques are not applicable in the clinical environment or lack accuracy.

OBJECTIVE

This study aimed to test the feasibility of a mobile neuroimaging-based clinical augmented reality (AR) and artificial intelligence (AI) framework, CLARAi, for objective pain detection and also localization direct from the patient’s brain in real time.

METHODS

Clinical dental pain was triggered in 21 patients by hypersensitive tooth stimulation with 20 consecutive descending cold stimulations (32°C-0°C). We used a portable optical neuroimaging technology, functional near-infrared spectroscopy, to gauge their cortical activity during evoked acute clinical pain. The data were decoded using a neural network (NN)–based AI algorithm to classify hemodynamic response data into pain and no-pain brain states in real time. We tested the performance of several networks (NN with 7 layers, 6 layers, 5 layers, 3 layers, recurrent NN, and long short-term memory network) upon reorganized data features on pain diction and localization in a simulated real-time environment. In addition, we also tested the feasibility of transmitting the neuroimaging data to an AR device, HoloLens, in the same simulated environment, allowing visualization of the ongoing cortical activity on a 3-dimensional brain template virtually plotted on the patients’ head during clinical consult.

RESULTS

The artificial neutral network (3-layer NN) achieved an optimal classification accuracy at 80.37% (126,000/156,680) for pain and no pain discrimination, with positive likelihood ratio (PLR) at 2.35. We further explored a 3-class localization task of left/right side pain and no-pain states, and convolutional NN-6 (6-layer NN) achieved highest classification accuracy at 74.23% (1040/1401) with PLR at 2.02.

CONCLUSIONS

Additional studies are needed to optimize and validate our prototype CLARAi framework for other pains and neurologic disorders. However, we presented an innovative and feasible neuroimaging-based AR/AI concept that can potentially transform the human brain into an objective target to visualize and precisely measure and localize pain in real time where it is most needed: in the doctor’s office.

INTERNATIONAL REGISTERED REPOR

RR1-10.2196/13594
SIMULTANEOUS ESTIMATION OF MOMETASONE FUROATE AND FORMOTEROL FUMARATE BY HPLC METHOD IN ROTACAPS
Authors: Zanwar Aarti S. , Sen Dhanya B. , Sen Ashim Kumar , Seth A. K.
Published: February 2019

Objective: To develop and validate a simple and sensitive RP-HPLC method for the simultaneous determination of mometasone furoate (MOM) and formoterol fumarate (FOR) in pharmaceutical dosage forms.

Methods: In RP-HPLC method, chromatographic separation was achieved using a mixture of a solvent system consisting of methanol–water (pH 3.5) in the ratio of 85:15 % v/v at a flow rate of 1 ml/min and detection was carried out at 225 nm.

Results: The run time for the simultaneous estimation of drugs for the proposed method was 10 min as drugs eluted at 5.217 min (MOM) and 8.650 min (FOR). The linearity was found in the range of 33.33-299.97 μg/ml and 1-9 μg/ml for MOM and FOR, respectively. The values of limit of detection and limit of quantification were 3.634, 0.266 µg/ml and 11.014, 0.807 µg/ml, which indicates the sensitivity of the method for the estimation of MOM and FOR, respectively. The results of recovery studies for both the drugs were within the range i.e. 98.87-101.48 % which indicates the accuracy of the method. Relative standard deviation obtained from repeatability and reproducibility studies were less than 2% indicates the precision of the method. The proposed method was validated according to ICH guidelines.

Conclusion: The proposed RP-HPLC method was found to be sensitive and precise because of the low LOD, LOQ and % RSD values (<2). The proposed work does not require acetonitrile and ion pairing reagent as compared to the reported methods. Therefore, method can be used preferably for routine analysis due to its simplicity and economic advantages.
EVALUATION OF BACTERICIDAL ACTIVITY OF AN ANTISEPTIC GELTHROUGH THE DILUTION-NEUTRALIZATION METHOD
Authors: Arias-Palacios Janeth Del Carmen , ESQUIVEL LIBARDO HERNANDEZ , Medina Dorelly Sandoval , B. Tatiana Diaz
Published: February 2019

Objective: To evaluate the bactericidal activity of an antiseptic gel for hygiene and disinfection of the hands by rubbing.

Methods: The dilution-neutralization method was used according to Colombian Technical Standard NTC, 2009, 12, 16 in Instituto Colombiano de Normas Técnicas y Certificación (ICONTEC), 5 strains, over 6 different types and with 6 replicas per time were exposed to the antiseptic gel, using Letheen Broth as a neutralizer substance.

Results: A 99% of reduction was obtained with Staphylococcus aureus 6538, Enterococos hirae 10541, Pseudomonas aeruginosa 15442 and Klebsiella sp, within the first 30 s of exposure to the gel and within the first 60 s of exposure using the Escherichia coli 19538. All strains used coming from American Type Culture Collection (ATCC).

Conclusion: It was confirmed that the product is effective. In presence of a neutralizer substance, the microorganisms were not inhibit, so the growing reduction occurs due to the action of the product.
POLYPHARMACY INDUCED DRUG INTERACTIONS, ADVERSE DRUG REACTIONS (ADR) AND MEDICATION ERRORS IN TERTIARY CARE SOUTH INDIAN HOSPITAL
Authors: R. Siddarama , J. Bharath Naidu , P. Joshisree K. , V. Sahithi Lakshmi
Published: February 2019

Objective: To study the pattern of drug interactions (DI) in our hospital and to identify whether it is associated with polypharmacy. To determine the level of severity of potential drug-drug interactions (PDDI), to detect, monitor and prevention of ADRs in the hospitalized patients and to identify the medication errors (ME).

Methods: A prospective interventional study was conducted in a 300 bedded tertiary care South Indian hospital for a period of 6 mo. Prescriptions were analysed for PDDI using Micromedex software 2.2. The causality and severity of ADRs were assessed by using Naranjo’s, WHO UMC Scales and Hart wigs severity scales. ME was identified by review of patient drug charts.

Results: Total 190 prescriptions were analyzed, in which 1028 drug interactions were seen. Out of which 718 were DDI, 198 DFI, 100 DEI, and 12 DTI were observed. More number of DI was seen in cardiovascular drugs, antibiotics followed by antacids and antiulcer agents. A total of 52 ADRs were identified in 43 patients. Diuretics, cardiovascular drugs were associated with a higher incidence of ADRs followed by Anti-Diabetic agents. 58 ME was seen in 190 prescriptions, among them omission error, prescribing errors and Wrong dose error was seen.

Conclusion: Clinical pharmacist plays a potential role in the health care system in assisting the physician i.e. modifying the number of drugs taken, number of doses taken, medication adherence, identification of drug interactions, preventing, monitoring and detection of ADRs and identifying the medication errors.
THE BENEFICIAL EFFECT OF 20% SUNFLOWER SEED OIL CREAM ON MILD ATOPIC DERMATITIS IN CHILDREN
Authors: Dwiyana Reiva Farah , Darmadji Hartati Purbo , Hidayah Risa Miliawati Nurul , Hergyana Fitra , Gondokaryono Srie Prihiantini , Diana Inne Arline , Sutantoyo Catherina Jessica , Gunawan Hendra
Published: February 2019

Objective: The objective of this study was to evaluate the beneficial effect of topical applications of 20% sunflower seed oil (SSO) in decreasing the transepidermal water loss (TEWL) and scoring of atopic dermatitis (SCORAD) index value in mild atopic dermatitis (AD) pediatric patients in Bandung, Indonesia.

Methods: This was a randomized study involving 20 children with mild AD (SCORAD<25) in Bandung, Indonesia. They were divided into 2 groups: the experimental group treated with 20% SSO cream and the control group treated with a common moisturizing cream for four weeks. The TEWL score including SCORAD index was evaluated at baseline, week 1, week 2, and week 4.

Results: A total of 20 participants completed the study. In the first week, the control group had TEWL score decrement by 36.62% while the experimental group by 28.89% (p=0.88). In the fourth week, the TEWL decrements of the experimental and control group were by 56.94% and 52.50%, respectively (p=0.20), and this was followed by an improvement of SCORAD index in both treatment groups.

Conclusion: The 20% SSO cream has a beneficial effect in decreasing the TEWL score and improving SCORAD indices. Therefore, it can be considered as an alternative treatment for mild AD among children.
ESTIMATION OF BACOSIDE-A IN BACOPA MONNIERI AERIAL PARTS USING TLC DENSITOMETRY
Authors: KUMAR RAJESH , SINGH TEJPAL , KUMAR DEEPAK , SINGH MANDEEP , KAUR SANDEEP , GARG RAJEEV
Published: February 2019

Objective: The objective of the present work was to formulate and evaluate a stable, odour free garlic powder loaded floating matrix tablet for the treatment of peptic ulcers.

Methods: A gastro-retentive floating matrix tablet (FMT) formulation of garlic powder (GP) was prepared using various concentrations of hydroxypropyl methylcellulose K4M (HPMC K4 M) and effervescent system (sodium bicarbonate and citric acid in 1:1 % w/w) to achieve desirable floating time (FT), floating lag time (FLT) and drug release. Wet granulation method was selected using ethanol as a binder for preparation of tablet. 32 full factorial designs were used for selection of suitable polymer concentration and effervescent system. Nonenteric film coating was applied to mask GP odour.

Results: It was observed that FMT with optimum quantities of HPMC K4M and the effervescent system showed 97 % of drug release in 12 h with FT up to 10 h and minimum FLT of 3 min. There was no significant change in FLT, FT and drug content during the stability study of FMT.

Conclusion: A stable, sustained release FMT of GP tablets using HPMC K4M and an effervescent system was successfully prepared. This formulation can overcome problems of taste and odour masking, gastric irritation, and loss of active constituents present in garlic.
THE ROLE OF INFORMATION TECHNOLOGY IN THE IMPLEMENTATION OF LEAN CONCEPT
Authors: Pavlović Milica , Radosavljević Marija , Milojević Radenko
Published: February 2019

Achieving and strengthening competitive advantage represents the key factor for survival and success of the modern businesses. It is a fact that successful implementation of Lean management leads to increased productivity and competence. However, in order to maintain profitability and business stability, it is necessary to support Lean concept, which can be provided, above all, by the application of modern information technology. In that sense, by applying the ERP system, it is possible to adapt basic Lean principles to the requirements of a modern environment characterized by constant change of demand and needs of the consumers/users. The main goal of the research is to examine the existing level of application of modern information technologies, as well as the level of attention paid to the integration of Lean concept and software solutions in enterprises in the Republic of Serbia. Theoretical aspect of the research is related to finding appropriate grounds for concluding on the basis of the existing literature. In this paper, research gaps and proposed further research directions have been identified. By applying the appropriate statistical tools (descriptive statistics, cluster analysis, correlation analysis) it was finally concluded that the enterprises which have substantially implemented the practice and principles of lean management are at the same time those who implement IT in their business, i.e. the information systems which support the implementation of lean practice.
ENGLISH FOR ACADEMIC PURPOSES AND THE ENHANCEMENT OF FRENCH TRAINEE CONTENT TEACHERS’ PROFESSIONAL SKILLS
Authors: WOZNIAK Severine
Published: February 2019

This paper explores the issue of syllabus design for English for Academic Purposes (EAP) classes by presenting a case study carried out at the Grenoble Faculty of Economics and the Grenoble Initial Teacher Training College (France). The study had two objectives: develop prospective and newly recruited content teachers’ professional skills, notably the ability to teach their subject in English on an occasional basis, and help them reflect on their professional practice. In order to do so, mandatory EAP modules for all trainee content teachers (TCT) of disciplines other than language studies were implemented to provide TCTs with an introduction to content and language integrated learning (CLIL) and to train them to teach in a CLIL format. In this paper two types of data are analyzed: the assessment of TCTs’ final assignment and the responses to a questionnaire aiming at gathering TCTs’ feedback on the EAP modules.
EXAMINING PEDAGOGICAL CONTENT KNOWLEDGE OF ESP TEACHERS
Authors: Bozic Lenard Dragana , Lenard Ivan
Published: February 2019

A prerequisite for successful knowledge transfer is for a teacher to have sound pedagogical content knowledge, i.e. to have understanding of students’ learning abilities, educational context, content and to employ appropriate instructional techniques. The aim of this paper was to study English for Specific Purposes (ESP) teachers’ teaching experience. For that purpose, 47 ESP teachers working at 7 Croatian universities voluntarily participated in an anonymous survey whose results were processed in SPSS. The results indicated that the teachers compile their teaching materials consulting various available resources, but rarely cooperate with their specialized course colleagues despite recognizing the importance and fruitfulness of such cooperation. In spite of feeling less confident about content knowledge, the teachers prepare thoroughly and present content in an appealing and interesting way. Finally, the teachers carry out course evaluations implementing students’ suggestions into their courses, all of which point to the teachers’ carefully considering all elements of the teaching process constantly aiming to improve both their own and students’ performance.