bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparison of effects of curcumin and beta-carotene on ovarian damage caused by cisplatin
Authors: Ceyhan Ayse , Baran Munevver , Suna Pinar Alisan , Cengiz Ozge , Yay Arzu
Published: June 2023

We investigated the potential protective effects of curcumin (CUR) and beta-carotene (BC) against cisplatin (CIS)-induced ovarian damage using histological and immunohistochemical methods. We used 56 female Wistar albino rats, divided randomly into seven groups. Control rats did not receive any treatment; the sham group was administered 1 ml/kg sesame oil by gavage; the CIS group was administered 5 mg/kg CIS; the CUR group was administered 200 mg/kg CUR; the BC group was administered 200 mg/kg BC; the CUR + CIS group was administered CIS after administration of CUR; the BC + CIS group was pretreated with BC before CIS injection, then administered CIS. The ovaries of all groups were excised five days after the last application. We assessed histopathology and counted and classified follicles. Expression of anti-Mullerian hormone (AMH) and nuclear factor-kappa B (NF-κB) was detected immunohistochemically. Apoptosis was evaluated using the TUNEL method. We found that CUR and BC are protective against decreased numbers of primordial, primary, preantral, secondary, and tertiary follicles caused by CIS. AMH immunoreactivity was nearly the same for the control and CUR + CIS groups; both Cur and BC decreased ovarian NF-κB levels compared to controls. Apoptotic cell counts indicated that CUR exerts a stronger anti-apoptotic effect than BC.
A CPT modified interval type-2 hesitant fuzzy PROMETHEE II model to prioritize risks in self-driving vehicles
Authors: Chai Naijie , Zhou Wenliang , Lodewijks Gabriel
Published: June 2023

With the increasing development of self-driving vehicles, there are various substantial risks in the interaction between automated driving technology and conventional transport system along with users, how to prioritize the risks involved in self-driving vehicles is regarded as a considerably complex multi-criteria decision making (MCDM) problem. In response to this, this study aims to propose a novel hybrid MCDM method for quantitatively identifying and prioritizing major types of risks related to self-driving vehicles, and addressing the main issues in the decision process, including information loss, criteria attribute and risk preference. The interval type-2 hesitant fuzzy linguistic term set is used to express double uncertainties on the mutual influence degree among criteria performances associated with each alternative. A combination weight method is developed to measure criteria weight and to investigate the interaction between criteria. And a cumulative prospect theory modified PROMETHEE II model considering criteria properties and risk preference simultaneously is developed to prioritize risks in self-driving vehicles. The findings of this study indicate that the Cyber Attack Risk (A2), Reputational Risk (A1) and Internet Outage Risk (A3) are specified as the top three prioritized risks. The sensitivity analysis illustrates that the final prioritization of risks is influenced by changing criteria weight, criteria properties and risk preference. The comparative analysis demonstrates that the proposed model turns out to be very practicable and feasible, due to its large distinction degree.
Stability, continuability, and boundedness for solutions to the second order stochastic delay integro-differential equation
Authors: Mahmoud Ayman M.
Published: June 2023

In this paper, we investigate the sufficient conditions that guarantee the stability, continuability and boundedness of solutions for a type of second order stochastic delay integro-differential equation (SDIDE).
To demonstrate the main result, we employ the Lyapunov functional. An example is provided to demonstrate the applicability of the obtained result, which includes the results of this paper and obtains better results than those available in the literature.
MSC 2020. 34C11; 34K20; 34D20; 34K50; 60H35.
Outcomes of Pediatric End Stage Renal Disease Patients with Moderate To Severe Covid-19 Infection Who Underwent Hemodialysis With Hemoperfusion In A Tertiary Subspecialty Hospital In Metro Manila: A Retrospective Single Center Study
Authors: Roberto Kathrine S
Published: June 2023

BACKGROUND
SARS-COV 2 became a pandemic in the early part of 2020 affecting individuals of all ages. Patients with End Stage Renal Disease who have COVID-19 infection are at higher risk for morbidity and mortality. There are studies on the use of of hemoperfusion in patients with COVID, however, data on its use in the pediatric population are scarce and conflicting.
OBJECTIVE
The objective of this study is to determine the clinical outcomes of pediatric end stage renal disease patients with moderate to severe COVID-19 infection who underwent hemodialysis with hemoperfusion in a tertiary subspecialty hospital in Metro Manila
METHODS
Retrospective cohort study was done. All eligible patients were included in the study. Data collection was conducted through chart review of medical records of ESRD patients <19 years of age admitted at the National Kidney and Transplant Institute from March 1, 2020 to March 1, 2022, presenting with moderate to severe COVID infection. Inflammatory markers and Chest xray were repeated to compare the values from baseline after 1-4 sessions of hemoperfusion. Clinical outcomes were determined in terms of discharge, duration of hospital stay, resolution of symptoms, progression of the severity of COVID infection, and final disposition either death or discharged.
RESULTS
C-Reactive Protein (CRP), Erythrocyte Sedimentation Rate (ESR), Lactate Dehydrogenase (LDH), and Ferritin decreased after 2-3 sessions of hemodialysis with hemoperfusion but the results were not statistically significant. Procalcitonin significantly decreased after the second session (p=0.046). Pneumonia on Chest xray decreased across all sessions. All patients showed clinical resolution of symptoms and were discharged.
CONCLUSION
The combined use of hemodialysis and hemoperfusion can be used as adjunct treatment for moderate to severe COVID infection after maximizing supportive and medical management. Should it be employed, 2-3 sessions are safe to improve the patient’s clinical status. Keywords: End Stage Renal Disease, COVID-19 infection, hemoperfusion, inflammatory markers
Incidence and Risk Factors of Remnant Gastric Cancer after Gastrectomy for Gastric Cancer: A Population-Based Study from the SEER Database (2000-2020)
Authors: Yan Shangcheng , Cheng Ming , Peng Wei , Liu Tianhua , Zhang Jingyu , Sheng Mengchao , Ren Rui , Chen Qiang , Gong Wei , Xing Chungen , Wu Yongyou
Published: June 2023

Background.
Gastric cancer (GC) constitutes a major health problem in the U.S., of which remnant gastric cancer (RGC) occurs less frequently. The rate of RGCs after gastrectomy for GC is increasing recently due to improved survival and screening, however, their incidence and risk have not been reported in the U.S. population. The objective of this study was to evaluate the incidence and elevated risk of RGC after GC gastrectomy in the U.S., and to identify the risk factors.
Methods.
Patients diagnosed with first primary GC in 2000–2015 and those who developed RGC were identified from Surveillance, Epidemiology and End Results (SEER) database. Fine-Gray regression was used to estimate the cumulative incidence and to identify risk factors. Standardized incidence ratios (SIRs) were calculated by Poisson regression to compare the risk with the general population.
Results.
Among 21566 patients included in the cohort, 227 developed RGC. The 20-year cumulative incidence of RGC was 1.88%. Multivariate analysis showed that hazard ratios were significantly higher in patients with age over 55 years, widowed and single marital status, unspecified tumor site, and T4 tumor, but lower in patients with diagnosis in 2010–2015, female sex, and $75000 + income. SIR was 7.70 overall and > 4.5 in each stratum.
Conclusions.
Cumulative incidence and risk for RGCs increased continuously in patients underwent GC gastrectomy. Earlier diagnosis, older age, male sex, marital status, lower income, and invasion depth are independent risk factors for RGC development. Close and lifelong endoscopy surveillance should be recommended for these patients.
Association of Metabolic Syndrome and Ischemic Changes in ECG: Result from a Population-Based Study
Authors: Soflaei Sara Saffar , Varasteh Naeemeh , Pourali Ghazal , Azarkar Setareh , Ghalibaf AmirAli Moodi , Mohammadi-Bajgiran Maryam , Ebrahimi Mahmoud , Alimi Hedieh , Shahri Bahram , Izadi-Moud Azadeh , Yadollahi Asal , Bijari Moniba , Ferns Gordon A. , Esmaily Habibollah , Ghayour-Mobarhan Majid , Moohebati Mohsen
Published: June 2023

Background Metabolic syndrome (MetS) is a set of metabolic impairments that are all risk factors for cardiovascular diseases (CVDs). To distinguish and anticipate the CVD risk, an electrocardiogram (ECG) can be utilized. While the exact association between MetS components and ECG abnormalities isn’t well established yet, we designed this study to verify the association between MetS components and ischemic ECG presentations. Methods This cross-sectional study was conducted on individuals aged 35–65 years as part of the population-based Mashhad stroke and heart atherosclerotic disorder (MASHAD) study. International Diabetes Federation (IDF) criteria were utilized to categorize the participants into two groups: those with and without MetS. ECGs were coded using the Minnesota coding system. The association between each MetS component and every single ischemic ECG presentation was analysed separately. Results Among the 9035 available ECG data, the general prevalence of ischemic ECG presentation was significantly higher in those with MetS than in those without (p < 0.05), except for minor ischemia (P = 0.787). Multiple logistic regression analysis showed that MetS was independently associated with major ischemia presentation in ECG (OR = 1.254, 95% Cl: 1.103–1.425, P < 0.001), but there wasn’t any association found with minor ischemia, after adjustment for age, sex, smoking, CVD family history, and physical activity level. Among Mets components, triglycerides, fasting blood glucose, waist circumference, and systolic and diastolic blood pressures had significantly positive associations with ischemic ECG presentations in the case of any association. Elevated high-density lipoprotein cholesterol level had negative associations with ischemic ECG presentations, while it had a significant positive association only with ST-segment elevation (OR = 1.021, 95% Cl: 1.011–1.031, P < 0.001). Conclusions MetS and its components showed an association with ischemic ECG presentations, but these associations were diverse, based on each MetS component and ischemic ECG abnormality.
Remnant cholesterol is an additional risk factor for cardiovascular disease beyond LDL cholesterol; Nationwide cohort study
Authors: Jung Han Na , Huh Ji Hye , Han Kyung-Do , Roh Eun , Kang Jun Goo , Lee Seong Jin , Ihm Sung-Hee
Published: June 2023

Background
Although elevated remnant cholesterol (remnant-C) level is considered an independent predictor of cardiovascular disease (CVD), it was not established in relatively healthy individuals. We investigated whether elevated remnant-C is a risk factor for CVD in the general population.
Methods
In total 8,874,254 Korean adults with unknown history of CVD were recruited in 2009 and followed until the date of incident myocardial infarction (MI) or ischemic stroke or December 31, 2018. Multivariate Cox regression models were used to estimate the risk for incident CVD associated with remnant-C.
Results
There were 184,771 individuals with incident CVD consisting of MI and ischemic stroke during 8.3 years of follow-up. The adjusted hazard ratios in the highest quartile of remnant-C were 1.681 (95% confidence interval, 1.636–1.726) for MI and 1.433 (1.407–1.46) for stroke. This pattern persisted when patients were stratified by age, sex, statin or fibrate use, and other cholesterol levels. Increased risk of MI or stroke owing to high concentrations of remnant-C was profound in patients with fewer traditional CVD risks (e.g. young age, women, non-obese, and those without hypertension, metabolic syndrome, chronic kidney disease, and diabetes). A remnant-C level ≥ 30 mg/dL was associated with an increased risk of CVD regardless of low-density lipoprotein cholesterol (LDL-C) levels being on target (LDL-C < 100mg/dL).
Conclusions
Elevated remnant-C is associated with an increased risk of CVD independent of traditional risk factors, including LDL-C. This finding suggests that remnant-C is an important CVD risk factor even in individuals with relatively low risk of atherosclerotic cardiovascular disease.
Certification of novel lncRNA based on analysis of ceRNA network in digestive system pan-cancer and characteristics of tumor immune microenvironment
Authors: He Zikang , Liang Shuang , Li Guoli , Wang Xueyan , Shen Ping , Wang Huan , Cui Rongjun
Published: June 2023

Background:Based on analysis of competitive endogenous RNA (ceRNA) and immune microenvironment, we screened their specific Long non-coding RNA (lncRNA) from the perspective of digestive system pan-cancer, and performed preliminary experimental validation.Methods:The transcriptome data of were downloaded from The Cancer Genome Atlas (TCGA) database, including esophageal carcinoma(ESCA), stomach adenocarcinoma (STAD), colorectal carcinoma (CRC) and liver hepatocellular adenocarcinoma (LIHC). We screened and predicted co-expressed differentially lncRNAs, miRNAs, and mRNAs of four tumors using R language. CeRNA networks were constructed by Cytoscape software.LASSO and Cox regression analysis were used to construct prognostic model. The application value of the prognostic model was assessed by combining clinicopathological features. The relationship between prognostic models and immune micro-environment was evaluated using Wilcoxon signed rank test. CCK8, scratch and Transwell assays were performed to analyze the effects of overexpression of lncRNA on CRC cells lines SW837 and SW620. The effect of overexpression of lncRNA on target proteins was detected using western blot.Results:Co-expressed lncRNAs 256, miRNAs 36, mRNAs 921 were obtained to construct the ceRNA network. LncRNA (WDFY3-AS2 and HOTAIR), miRNA (hsa-miR-21), and mRNA (OSR1) were screened using LASSO and Cox regression analysis to construct prognostic model. The survival rate of patients in the low-risk group was better than that in the high-risk group (P<0.001). The risk score and clinical stage could be used as independent prognostic factors for the digestive system pan-cancer. The risk score was positively correlated with the infiltration of multiple immune cells. The high-risk groups of CRC and LIHC were positively correlated with the expression of CD274, CTLA4, PDCD1, and HAVCR2 (P<0.05). Cellular experiments showed that the overexpression of WDFY3-AS2 reduced the survival rates of colorectal cancer cells, increased the healing time of scratched cells, and decreased the passage rate of transwell cells. Western blot assay suggested that WDFY3- AS2 can positively regulated the expression of OSR1.Conclusions:The prognostic model constructed based on the WDFY3-AS2/HOTAIR /hsa-miR-21/OSR1 ceRNA regulatory axis was able to assess the prognosis of pan-cancer of the digestive system, and the specific LncRNA WDFY3-AS2 inhibited the proliferation, invasion and metastasis of colon cancer cells.
Uncovering the Neuroprotective Effect of Vitamin B12 in Pneumococcal Meningitis: Insights into Its Pleiotropic Mode of Action at the Transcriptional Level
Authors: Cassiano Larissa Marcely Gomes , Oliveira Marina da Silva , Queiroz Karina Barbosa , Amancio Alice Muglia Thomaz da Silva , Salim Anna Christina de Matos , Fernandes Gabriel da Rocha , Carneiro Cláudia Martins , Coimbra Roney Santos
Published: June 2023

Background
The interplay between bacterial virulence factors and the host innate immune response in pneumococcal meningitis (PM) can result in uncontrolled neuroinflammation, which is known to induce apoptotic death of progenitor cells and post-mitotic neurons in the hippocampal dentate gyrus, resulting in cognitive impairment. Vitamin B12 attenuates hippocampal damage and reduces the expression of some key inflammatory genes in PM, by acting as an epidrug that promotes DNA methylation, with increased production of S-adenosyl-methionine, the universal donor of methyl.
Objective
This study aimed to investigate the effects of adjuvant therapy with vitamin B12 on microglial activation, inflammatory infiltrate within the central nervous system, as well as the hippocampal transcriptome and histone markings in infant rats with PM
Material and Methods
Elven-day-old rats were infected with S. pneumoniae via intracisternal injection and then administered either vitamin B12 or a placebo. After 24 hours of infection, the animals were euthanized, and apoptosis in the hippocampal dentate gyrus, microglia activation, and the inflammatory infiltrate were quantified in one brain hemisphere. The other hemisphere was used for RNA-Seq and RT-qPCR analysis.
Results
In this study, adjuvant therapy with B12 was found to modulate the hippocampal transcriptional signature induced by PM in infant rats, mitigating the effects of the disease in canonical pathways related to the recognition of pathogens by immune cells, signaling via NF-kB, production of pro-inflammatory cytokines, migration of peripheral leukocytes into the central nervous system, and production of reactive species. Phenotypic analysis revealed that B12 effectively inhibited microglia activation in the hippocampus and reduced the inflammatory infiltrate in the central nervous system of the infected animals. These pleiotropic transcriptional effects of B12 that lead to neuroprotection are partly regulated by alterations in histone methylation markings. No adverse effects of B12 were predicted or observed, reinforcing the well-established safety profile of this epidrug.
Conclusion
B12 effectively mitigates the impact of PM on pivotal neuroinflammatory pathways. This leads to reduced microglia activation and inflammatory infiltrate within the central nervous system, resulting in the attenuation of hippocampal damage. The anti-inflammatory and neuroprotective effects of B12 involve the modulation of histone markings in hippocampal neural cells.
Stochastic equilibrium of free trade under a FIGARCH volatility
Authors: boughabi houssam
Published: June 2023

Free trade for some economists gains so much attention, the horrible thing is though when a nation doesn't knit relations with other countries because this would harm the future gains almost if land or property is rare: what i had tried to mention is the importance of free trade as far as consumption is concerned, if the national tissue is almost based upon expenditures that's a farce, more than a farce; it's a black resort getting economists warry about the well being of their nations.
I had resolved for a complicated situation when almost no free trade is alive, when i give consumption as a benchmark for welfare.
Afterward i had dived into debt when proposing a model for the level of debt that takes in ation into account; just after we got a numerical resolution for the behavior of our model. Under the absence of arbitrage i have made an approximation that looks great for econometrics and finance.
JEL Classification. B27, C01.
‹Die Zukunft kann nicht beginnen›
Authors: Leineweber Christian
Published: June 2023

Die Betrachtungen des vorliegenden Beitrags basieren auf zwei Entgrenzungsdiagnosen: (1) Digitale Medien bewirken eine Entgrenzung von Raum und Zeit. (2) Digitalität geht mit einer Entgrenzung der Möglichkeiten von Handlungs- und Erfahrungswelten auf Basis sich verändernder Prozesse, Interaktionen und Praktiken an der Schnittstelle zwischen Mensch und (digitaler) Maschine einher. Ausgehend von diesen beiden Diagnosen lautet die These, dass Digitalität eine Veränderung der menschlichen Zukunftsoffenheit impliziert, weil algorithmische Operationen eine Bearbeitung von Kontingenz durch Berechenbarkeit und Vorhersagbarkeit ermöglichen. Diese These wird bildungswissenschaftlich hergeleitet und mit Fokus auf die Temporalität der Digitalität exploriert. Anschliessend werden erste Konsequenzen der gewonnenen Ergebnisse für die medienpädagogische Theoriebildung und medienpädagogisches Handeln diskutiert.
Die Entgrenzung von Kommunikationskulturen in Lehrpersonenkollegien
Authors: Dehmel Lukas , Meister Dorothee M. , Gerhardts Lara
Published: June 2023

Der Beitrag beschäftigt sich im Kontext der schulischen Arbeit mit Tablets mit der Entgrenzung von arbeitsverwiesenen und privaten Lebenskontexten in Lehrpersonenkollegien. Es geht hierbei um den nicht unbedingt intendierten Aspekt einer erheblichen Ausweitung der beruflichen Verfügbarkeit, der in der medienpädagogischen Forschung bisher kaum berücksichtigt worden ist. Dabei stellt die Analyse die Frage in den Mittelpunkt, wie und nach welchen Normen dieses Entgrenzungsphänomen in Lehrpersonenkollegien handelnd erzeugt wird. Um das Thema grundlagentheoretisch einzuordnen, greift die Argumentation auf den Mediatisierungsansatz aus der Kommunikationswissenschaft zurück. Der Beitrag nutzt anschliessend einige Ideen aus der Schulkulturtheorie (Helsper et al.), die als Ausgangspunkt dienen, um die soziale Aushandlung des Entgrenzungsphänomens empirisch greifbar zu machen. Beide Theorielinien werden miteinander verknüpft und schaffen so ein theoretisches Fundament für die Auswertung. Entlang der eingenommenen Perspektive werden darauffolgend Gruppendiskussionen aus drei Lehrpersonenkollegien mit der Objektiven Hermeneutik interpretiert und miteinander verglichen. Dabei kommt die Analyse zu dem Ergebnis, dass im Zuge der Tablet-Einführung in allen drei Kollegien ähnliche berufliche Verfügbarkeitsverpflichtungen Einzug halten, die aber teilweise unterschiedlich ausgehandelt werden. Zusammenfassend ist festzuhalten, dass der Umgang mit den neuartigen Kommunikationsanforderungen von den Lehrpersonen stark problematisiert wird und eine Herausforderung darstellt. Zum Abschluss geht die Argumentation auf medienpädagogische Konsequenzen ein, die sich aus diesen Untersuchungsergebnissen ableiten lassen.
Identifikation von begrenzenden Faktoren in Schule
Authors: Obermeier Claudia , Müller Daniela , Profft Johanna , Hartung Julia , Vieregg Nicole
Published: June 2023

Der vorliegende Beitrag setzt sich mit der Frage auseinander, welche begrenzenden Faktoren sich in Bezug auf eine inklusiv-digital gestaltete Schule, auf Meso- und Mikroebene, identifizieren lassen und wie jene Begrenzungen aufgeweicht werden können. Hierfür werden die Ergebnisse aus vier Teilprojekten, des BMBF-geförderten Verbundprojektes Dig*In (Digitalisierung und Inklusion – Grundsatzfragen und Gelingensbedingungen einer inklusiven digitalen Schul- und Unterrichtsentwicklung) herangezogen. Innerhalb des Verbundprojektes wurden zwischen 2020 und 2021 Interviews, Gruppendiskussionen, Fokusgruppen und Workshops an deutschen Schulen durchgeführt, um den derzeitigen Zustand von Inklusion und Digitalisierung zu eruieren und analysieren. Die Teilprojekte I und II betrachten die Schulebene (Mesoebene) und geben einen Überblick über die konzeptionell übergeordnete Betrachtung der Verzahnung von Inklusion und Digitalisierung in Schule bzw. einen Einblick über bestehende Prozesse und Strukturen, welche die Verzahnung begrenzen oder begünstigen. Die Teilprojekte III und IV beleuchten die Unterrichtsebene (Mikroebene) und stellen dar, welche Potenziale der Einsatz digitaler Medien für die Ausgestaltung inklusiver Lehr-Lernszenarien und Arbeitsweisen mit sich bringt und welchen Begrenzungen sich Lehrpersonen gegenübersehen. Zusammenfassend konnte festgestellt werden, dass eine an inklusiven Werten und Prinzipien orientierte Schulkultur die Grundlage einer inklusiv-digital gestalteten Schule darstellt. Begrenzenden Faktoren – bspw. empfundener Doppelbelastung, unterschiedlichen Medienkompetenzen oder fehlendem Methodenwissen – begegnen die Lehrpersonen zumeist durch die Schaffung und Etablierung individueller Strukturen und Prozesse, wobei der Einsatz digitaler Medien als herausfordernd, aber zeitgleich auch förderlich für ein Mehr an Inklusion und Digitalisierung in Schule und Unterricht wahrgenommen wird.
KEZUHUDAN ISA AL-MASIH DALAM KITAB AL-ZUHD WA’L-RAQĀ’IQ DAN AL-ZUHD
Authors: Muhammad Hasyim
Published: June 2023

The ascetisc of Isa al-Masih is the most polular model in strengtening the ascetism doctrines among tasawwuf experts in clasical periods. At least it was depicted in clasical sunnite sufism that narrated the messages and stories about the escatism of Isa al-Masih. Above all, the more valid source, i.e. al-Qur’an and al-hadits are more than enough to strengten the doctrine of ascetism for the tasawwuf experts (sufi). Ascetism of Isa al-Masih was conformable to the concept of ascetismof the sufi, which meant that have nothing and belong to nothing (lā yamliku shaian walā yamlikuhu shaiun). Ascetism is not only merely spiritual position which is depicted in tasawuf, but ascetisme in this context is the spiritual it self.***Asketisme Isa al-Masih merupakan model yang paling populer dalam mem­perkuat doktrin asketisme di kalangan ahli tasawuf dalam periode klasik. Setidaknya itu digambarkan dalam sufisme sunni klasik yang menarasikan pesan dan kisah mengenai asketisme Isa al-Masih. Di luar itu semua, sumber yang lebih valid, yaitu al-Qur’an dan hadits lebih dari cukup untuk memperkuat doktrin asketisme bag para ahli tasawuf (sufi). Asketisme Isa al-Masih sesuai dengan konsep asketisme sufi yang artinya tidak memiliki apa-apa dan bukan milik siapa-siapa (lā yamliku shaian walā yamliku shaiun). Asketisme bukan sekedar posisi spiritual yang digambarkan di dalam tasawuf, tetapi asketisme dalam konteks ini adalah spiritual itu sendiri.
PENGALAMAN BERSUA TUHAN: PERSPEKTIF WILLIAM JAMES DAN AL-GHAZALI
Authors: Komarudin Komarudin
Published: June 2023

Experience of meeting God constitutes an interresting phenomenon and become the focus of interrest of many disciplines. Psychology and tasawuf are two disciplines which focusedly study this phenomenon applying different approaches. Ghazali is the representative of the dicsipline of tasawwuf and William James is the representative of the dicsipline of psychology. The both experts applied the different approaches in studying the religious experiences. Epistemological base on which William James used , has the scientific accountability but less accurate in the source of knowledge. In other side, Ghazali has a deep source of knowledge but less of rationality. An effort to compromise the both approach in order to study about the experience of meeting God will result in a comprehensive, deep, and objective depiction.***Pengalaman bersua Tuhan merupakan fenomena yang menarik dan menjadi titik perhatian banyak disiplin ilmu. Psikologi dan tasawuf merupakan dua disiplin ilmu yang memfokuskan kajiannya pada fenomena ini dengan menerapkan pendekatan yang berbeda. Ghazali adalah representasi dari disiplin ilmu tasawuf dan William James adalah representasi disiplin ilmu psikologi. Kedua ahli tersebut menggunakan pendekatan yang berbeda dalam mengkaji pengalaman keagamaan. Basis epistimologi yang digunakan oleh James memiliki akuntabilitas ilmiah namun kurang akurat dalam sumber pengetahuannya. Di sisi lain Ghazali memiliki sumber pengetahuan yang dalam namun kurang dari sisi rasionalitas. Upaya untuk mengkompromikan kedua pendekatan dalam rangka untuk mengkaji pengalaman bersua Tuhan akan menghasilkan penggambaran yang dalam dan obyektif.
PRASANGKA: POTENSI PEMICU KONFLIK INTERNAL UMAT ISLAM
Authors: Alfandi Muhammad
Published: June 2023

This study is about the potential prejudice sparked internal conflict of Muslims, especially between the group Nahdlatul Ulama (NU) and the Council of Tafsir Al-Qur'an (MTA) in Surakarta. Lately there is a conflict between NU and the MTA congregation. MTA is questioned by NU in some areas because of the materials and methods of preaching/dakwah considered to be provocative and less likely to appreciate the difference fiqhiyah and abusive deeds done by NU. From the reason above, the conflict between these two Islamic organizations appeared. One of the triggers that caused the internal conflict among Muslims is the certain group of Muslims can not understand well the other religious groups, which have different ideological backgrounds; that it affects the way of thinking, behaving and acting that are different from themselves. As a result, the internal relations marred by religious conflict, caused by the internal religious prejudice. Similarly, the possibility that occurred among the group of NU and MTA.
REVITALISASI ISLAM KULTURAL
Authors: Jamil M. Mukhsin
Published: June 2023

This research aims to explore one of Islamic movements in Indonesia after reformation of 1998. By using qualitative method, it is clear that the demarcation betweeen Islamic tradisionalism and Islamic modernism fluided culturally. Although at the same time polarization both become more political, which is made Indonesian Islamic mainstream loosed elan vital as sosial and cultural movement. There is the contradictory trends in the dynamic of Islamic thought and movement introduced by Islamc minority groups. In one side the trends are multiculturalism, anti coruption movement and appreciation to the local cultures which is ignorenced before by Islamic movement in Indonesia. In other side, political oriented in many Islamic movement is stronger. The dominant of traditional constructions of Islamic polical thought of sunni (fiqh al-siyasah) influenced to the Islamic movement to state orientation at same time ignored the society with their problem and cultural expression. The cultural Islam proposed new understanding to Islamic traditions with hermeneutic and remove the locus of movement forum political Islam to civil Islam.
MAKNA SIMBOLIK UPACARA SIRAMAN PENGANTIN ADAT JAWA
Authors: Irmawati Waryunah
Published: June 2023

Siraman (bathing) is a Javanese ritual ceremony that is done one day before the bride does the ijab qabul. In the siraman ritual, the operational rule and the equipments (uborampe) that are used are already definite (maton/pakem) as the symbols that have meanings. The meanings of the symbols in the siraman cannot be put off from Javanese context. Phenomenology and philosophy approaches using hermeneutic method towards siraman ritual are interpreted comprehensively to make the meanings of symbols clearly therefore the symbols in the siraman ritual can be understood. This research figures the inter relations among philosophy, culture and Islam.
DINAMIKA MASYARAKAT LOKAL DI PERBATASAN
Authors: Prasojo Zaenuddin Hudi
Published: June 2023

Community members living in borderland areas in Indonesia tended to be clasified as under-developed society in development aspects. Study on the borderland areas is still limited both in quantity and the impact of the study. Nanga Badau located in borderland between West Kalimantan (Indonesia) and Serawak (Malaysia) is one of the under-developed borderland area. This paper revealed the dynamic issues and the existence of local tradition in the context of globalization. It was showed that the original attitude of warn, friendly, and respect visitors express their openess toward global trend but still keep on local style. They are also realized on their position among global community. The open access abroad effected in the development of the interaction, information, and communication patterns among Iban Dayak. Sophisticated devices like mobile phone and television are familiar among Iban dayak in borderland area.
POLITIK DAKWAH DAN DAKWAH POLITIK DI ERA REFORMASI INDONESIA
Authors: Rosa Andi
Published: June 2023

This research activity parse dzikir majelis Susilo Bambang Yudhoyono (SBY) "Nurussalam" which has a strategic role in the democratic era. His status as a society organizations (NGOs) are positioned optimally by interest groups, political organizations and even into the container. By analyzing the dataobtained through interviews and documentation, the results of this study indicate that this council makes verses of the Qur’an that deals with the concept of al-‘ummah, al-ukhuwwah al-islamiyya, and al-ta'āwun as a cornerstone in interpreting para­graph integrative social which is then used as a propaganda entity. Proselytizing as mass communication, political communication line with more likely to use communication as a way to mobilize the masses massif. Even activities have been able to carry out the functions of political propaganda as part of the interest-group system.
MULTIKULTURALISME DAN HEGEMONI POLITIK PERNIKAHAN ENDOGAMI: IMPLIKASI DALAM DAKWAH ISLAM
Authors: Rahmaniah Syarifah Ema
Published: June 2023

This paper described a variety of views on the dynamics of endogamy marriage practiced by sharif community in Pontianak. This paper used the theory of hege­mony to analyze Surah al-Ahzab: 33 as the cause of endogamy among the descendants of 'Isa al-Muhajir (Ba ‘Alawi) that have migrated to the archipelago. One of her off spring grew and spread in Pontianak was called sharif or syarifah of Pontianak. The results of this study explained that there are three different attitudes about endogamous marriage, they are accept, reject and moderate thinking. The three different attitudes came out as the result of modernization, contact with foreign cultures, the influence of education, socio-economic, and the existing settlement pattern. There is a socio-political implications of the verses of hegemony that is keeping the values of the potential political kinship as social capital to raise awareness and political culture in the context of community participation and representation of sharif in local and national politics. But in sociocultural context. Once endogamy was understood as an absolute system that must be run so it may open space of social stratification that threatens women’s freedom and will open the spaces for subordination.
Ways to increase the sensitivity of line protection during abnormal operation on branches with low-power transformers
Authors: Gilmanov Ruslan Rustemovich
Published: June 2023

This article discusses various ways to solve the problem of recognizing short-circuit currents
at various abnormal operating modes on branches with low-power transformers. The following options for solving this problem will be considered: a method for increasing the sensitivity of distance protection lines to two-phase short circuits; operability of protection of long-range redundancy of transformers under the condition of longitudinal-transverse asymmetry; implementation of a distance protection stage using information about the currents from the supply ends of the branch line
Do ginásio ao Complexo de Ensino Estadual do Paraná: adesões e ressignificações em uma instituição de ensino (1900-1980)
Authors: Zaluski Jorge
Published: June 2023

Este texto tem por objetivo investigar sobre a trajetória do Colégio Estadual do Paraná ao longo do século XX. Localizado em Curitiba-PR, a partir da perspectiva da história da educação, é possível perceber como, essa instituição de ensino, em diferentes contextos, e, do ensino desenvolvido nela, esteve atrelado ao projeto de estado pautado em questões políticas, econômicas, culturais e sociais. Para isso, são utilizados como documentação histórica, legislações, fotografias, Planos Curriculares, dentre outros documentos, disponibilizados pelo Centro de Memória do Colégio Estadual do Paraná. A análise exposta apresenta contribuições para identificar o percurso da instituição e de adesões ou afastamentos de propostas educacionais desenvolvidas no período investigado.
O Grupo Escolar Carlota Barreira: “A estrela das obras sociais da paróquia” de Areia-PB (1968-1973)
Authors: Inocencio Yasmim Maria Dias dos Santos , Lima Niédja Maria Ferreira de
Published: June 2023

O artigo aborda a história de criação do Grupo Escolar Carlota Barreira, em Areia-PB (1968-1973), e se inserei no campo das instituições escolares. Inspirada no materialismo histórico-dialético, o estudo foi realizado mediante levantamento de fontes documentais identificamos indícios da forte presença da Igreja Católica na educação das crianças pobres e a ausência estatal no processo histórico de criação dessa instituição
Novel bone Morphogenetic Protein (BMP)-2/4 Consensus Peptide (BCP)
for the Osteogenic Differentiation of C2C12 Cells
Authors: Hwang Jin Wook , Han Youn Ho
Published: June 2023

Background:

Despite the promising clinical potential of bone morphogenetic protein
(BMP)-related therapies for bone formation, their side effects warrant the need for alternative therapeutic
peptides. BMP family members can aid in bone repair; however, peptides derived from BMP2/
4 have not yet been investigated.

Methods:

In this study, three candidates BMP2/4 consensus peptide (BCP) 1, 2, and 3 were identified
and their ability to induce osteogenesis in C2C12 cells was analyzed. First, an alkaline phosphatase
(ALP) staining assay was performed to evaluate the osteogenic effects of BCPs. Next, the
effects of BCPs on RNA expression levels and protein abundances of osteogenic markers were explored.
Furthermore, the transcriptional activity of ALP by BCP1 and in silico molecular docking
model on BMP type IA receptor (BRIA) were performed.

Results:

BCP1-3 induced higher RUNX2 expression than BMP2. Interestingly, among them,
BCP1 significantly promoted osteoblast differentiation more than BMP2 in ALP staining with no
cytotoxicity. BCP1 significantly induced the osteoblast markers, and the highest RUNX2 expression
was observed at 100 ng/mL compared to other concentrations. In transfection experiments,
BCP1 stimulated osteoblast differentiation via RUNX2 activation and the Smad signaling pathway.
Finally, in silico molecular docking suggested the possible binding sites of BCP1 on BRIA.

Conclusion:

These results show that BCP1 promotes osteogenicity in C2C12 cells. This study
suggests that BCP1 is the most promising candidate peptide to replace BMP2 for osteoblast differentiation.
Deep-RPA: Vulnerability Classification of a Genome for CRISPR/Cas9 Off-targets
Authors: Saddique Tausif Ur Rehman , Saloum Said S. , Razzaq Abdul , Husain Aamir , Baig Irfan Ahmad , Ali Zulqurnain , Khan Zulqurnain
Published: June 2023

Background:

Researchers working in genome engineering are making fast strides to precising the techniques of site-specific gene editing. CRISPR-Cas (Clustered Regularly Interspaced Short Palindromic Repeats) is one of the most recent gene editing techniques. It consists of a Cas9 nuclease and a single guided RNA (sgRNA) that targets DNA at the required target site. Consequently, along with on-targets, genomes may also have multiple off-targets, which is a potential drawback of gene editing techniques. Lab-based assays are used to examine the off-target effects of sgRNA. This challenge makes the technique questionable in terms of cost, time and efficacy. Deep learning techniques have been used efficiently to analyze biological data and calculate off-target sites in the genome.
This research aims to identify CRISPR off-targets within the genome as well as predict genome vulnerability for unexpected mutations using a deep learning approach.

Method:

This study presents a two-step data preprocessing and off-target prediction method that may be used to determine genome instability. A raw DNA sequence was initially preprocessed and subdivided into 20-bp long multiple substrings. These substrings were further categorized into perfect matches and mismatches. Secondly, average weights were assigned based on the CFD (Cutting Frequency Determination) of the off-targets that showed the genome's vulnerability. Finally, the deep neural network model was trained using random genomic data. To identify off-targets and predict genome vulnerability, a Deep-RPA model was trained and tested on the DNA sequence of the Arabidopsis model plant.

Results:

The results demonstrated the accuracy and validity of Deep-RPA by accurately predicting off-targets and genome vulnerabilities on different sample sequences. The proposed model was evaluated through stratified five-fold cross-validation, which attained an average accuracy of 99 percent for predicting genome vulnerability. The results illustrated satisfactory improvement compared to existing solutions.

Conclusion:

The proposed design using a 1D CNN has shown significant improvement in text-based sequence analysis and has outperformed current methods by a wide margin.
Anti-proliferative, Anti-angiogenic, Anti-apoptotic, and Anti-metastatic Effects of Mushroom
Authors: Mishra Vartika , Yadav Priyanka , Tiwari Pandey Aprajita , Pandey Tiwari
Published: June 2023

Cancer is the second leading cause of mortality globally after cardiovascular
diseases. It is attributed to various genetic and epigenetic changes in the genome, while
lifestyle and environmental factors have a say in its rate of progression. Conventional
agents like chemotherapy, radiotherapy, and surgical interventions though successful to
some extent, are always associated with toxic side effects. A promising alternative
could be herbs that form a part of our daily consumption. Mushrooms consumed
worldwide have been found to be a treasure of macromolecules like β-glucan, α-glucan,
resveratrol, concanavalin A, cibacron blue affinity protein, p-hydroxybenzoic acid,
ergosterol, linoleic acid, etc. that are responsible for mediating anti-tumor,
immunomodulatory, antioxidant and anti-diabetic roles. Various experiments have
demonstrated the potential of mushrooms as an anti-cancer agent. This chapter
summarizes the effect of mushroom extracts and bioactive constituents against various
hallmarks of cancer like sustained proliferation, evading apoptosis, angiogenesis,
immune evasion and metastasis, along with underlying mechanisms. At the end of the
chapter, we also talked about what still can be done and where we need to focus so that
future studies can add to the already existing knowledge about this natural reservoir of
anti-cancer compounds.
Cybersecurity and Blockchain
Authors: Saini H. , Garg V.
Published: June 2023

Blockchain technology provides unprecedented security to sensitive data to
both businesses and individuals; it has become one of the most famous methods for
securing data through a decentralized system. Cybercrime is a serious threat to
enterprises as hackers are devising new techniques and implementing them to execute
cybercrime. Blockchain technology has the potential to give higher security, which has
no limit to keeping important and sensitive information and records. Blockchain is the
technology that could go a long way in fighting this and keeping digital information
safe and secured. Blockchain technology strengthens cyber security for different areas
of industries and plays a vital role in making data more secure with its decentralized
technology. Through this chapter, the authors will get to know how blockchain
technology helps in providing cyber security to the different sectors of industries with
its advantages and disadvantages of blockchain. The author also explores the role of
blockchain in cybersecurity and the future benefits of blockchain technology to
strengthen cybersecurity.
Multi-chain Deployment over Smart Contracts to Enhance Security
Authors: Gupta N. , Agrawal R.
Published: June 2023

A blockchain is a data structure in which each block is linked to the next in a
time-stamped chronological manner. Each block is cryptographically linked to the
others. This is a global distributed ledger that contains an immutable public record of
financial transactions. Every new record will be reviewed across the distributed
network before being saved in a block. All information is verifiable and auditable once
it is deposited on the ledger, but it cannot be edited. It will be an underestimation to say
that Blockchain Technology is one of the most inventions of this 21st century. More
people are considering that the decentralization and translucence that comes along with
blockchain technology have the prospective to jiggle multiple industries to its very
staple. This article reconnoiters different blockchain applications and their deployment
approaches. In other facets, Multichain is a platform for the creation and distribution of
private blockchains, either within or between organizations. Likewise, there are many
more blockchain applications than just cryptocurrency, and they can unsettle way more
sectors than just the finance sector. We intentionally avoided showing the Blockchain’s
impact on the banking sector to keep the list as non-fintech as possible. Smart contracts
are well customary as the greatest enabling technology for blockchains. With them, a
blockchain ecosystem becomes self-governing, open, consent, and credible. It is
through a compilation of smart contracts that blockchains can operate without human
intervention.
The smart contracts are established to deploy at the predefined blockchain nodes. They
can be entreated by the call-backs either from the blockchain system, the other smart
contracts, or the participants’ information systems.
Usually, blockchain operations and application-related rules can be predetermined as
smart contracts. The use cases and their real-world functions differ, but the benefits
derived from using the technology remain unchanged: immutability, transparency,
redundancy, and security.
Security Challenges For Cloud-Based Email Infrastructure
Authors: Bhardwaj Akashdeep
Published: June 2023

To stay connected and interact with global peers, friends, co-workers, and
corporate employees, use email communication technology to perform business with
customers and communicate with each other globally. Emails are the best and simplest
way of cyber communication. Email is often the first thing we do when entering the
office as well as the last thing we do when going to bed. With Cloud-based services
providing email servers and infrastructure hosted over the Internet, Security assumes a
significantly high level of priority in today’s cyber world. This chapter reviews the
academic literature published on security challenges faced by Email Infrastructure over
Cloud, discusses the limitations of Email protocols, and compares using cloud-based
email infrastructures and on-premises email servers.
Job crafting among rehabilitation center employees
Authors: Sekhniashvili Tamar
Published: June 2023

The goal of the present research was to study job crafting among personnel employed at a rehabilitation center in relation to variables such as age, education (bachelor’s degree, master’s degree) and job position (therapist, supervisor). Hypothesis, which states that any employee, regardless their education and position at work, can master job crafting (Tims et al., 2012) was once again supported by the present study. Analysis showed that data of bachelors, masters, managers and professionals (therapists) were not statistically different from each other. Studies (Lichtenthaler & Fishbach, 2019; Rudolph et al., 2017) have demonstrated the associations between job crafting, job satisfaction and work engagement. Therefore, it was interesting to explore these associations among people employed at a rehabilitation center. The findings showed that job crafting significantly predicted engagement.