bluuebunny/crossref_metadata_2025 huggingface dataset:
Association of Mediterranean Diet Adherence with Disease Progression Characteristics, Lifestyle Factors and Overall Survival in Gastric Cancer Patients
Authors: Pavlidou Eleni , Papadopoulou Sousana K. , Tolia Maria , Mentzelou Maria , Tsoukalas Nikolaos , Alexatou Olga , Tsiouda Theodora , Tsourouflis Gerasimos , Psara Evmorfia , Bikos Vasileios , Kavantzas Nikolaos , Kotta-Loizou Ioly , Dakanalis Antonios , Vorvolakos Theofanis , Giaginis Constantinos
Published: November 2023

Background: The Mediterranean diet (MD) exerts a protective effect against cancer development and progression; however, the evaluation of its impact on gastric cancer still remains quite scarce. The present study aims to evaluate the association of MD adherence during the lifespan with disease progression characteristics, lifestyle factors and overall survival in gastric carcinoma patients. Methods: This is an observational, cross-sectional study conducted on 186 gastric cancer patients followed up for a median time interval of 57 months or until death due to cancer disease. Tumor histopathological characteristics were retrieved from patients’ medical records, while validated questionnaires assessing, immediately after the time of diagnosis, health-related quality of life, physical activity levels, sleep quality, depression, anxiety and MD adherence during the lifespan were used. Results: Higher MD adherence during the lifespan was significantly associated with younger patients (p = 0.0106), regular smoking (p < 0.0001), abnormal BMI status (p < 0.0001), intestinal-type gastric carcinoma (p = 0.0111), high tumor histopathological grade (p < 0.0001) and earlier disease stage (p < 0.0001). Moreover, patients with elevated MD adherence during their lifespan showed significantly better health-related quality of life (p < 0.0001), higher physical activity levels (p < 0.0001), more adequate sleep quality (p < 0.0001) and lower prevalence of depression (p = 0.0003) and anxiety (p = 0.0006) compared to those with reduced MD adherence. In multiple regression analysis, elevated MD compliance during the lifespan was independently correlated with longer overall patient survival after adjustment for several confounders (Cox regression analysis, p = 0.0001). Conclusions: Higher MD adherence during the lifespan was associated with less advanced tumor histopathology characteristics and favorable mental and physical lifestyle factors. Moreover, higher MD adherence during the lifespan was also independently correlated with longer overall survival in gastric carcinoma patients. Thus, adopting a healthy dietary pattern like the MD during the lifespan may act as a preventive agent in combination with a healthy lifestyle against gastric cancer development and progression.
Prevalence of Multidrug-Resistant Pseudomonas aeruginosa Isolated from Dairy Cattle, Milk, Environment, and Workers’ Hands
Authors: Badawy Basma , Moustafa Samar , Shata Radwa , Sayed-Ahmed Mohamed Z. , Alqahtani Saad S. , Ali Md Sajid , Alam Nawazish , Ahmad Sarfaraz , Kasem Nahed , Elbaz Elzahara , El-Bahkiry Hesham S. , Radwan Reda M. , El-Gohary Adel , Elsayed Mona M.
Published: November 2023

Pseudomonas aeruginosa is an opportunistic pathogen causing severe infection in animals and humans. This study aimed to determine the ecological distribution and prevalence of multidrug-resistant (MDR) P. aeruginosa isolated from dairy cattle, the environment, and workers’ hand swabs. Samples (n = 440) were collected from farms and households (n = 3, each). Rectal swabs, udder skin swabs, milk, workers’ hand swabs, feed, water, water sources, and beddings were collected. Samples were subjected to the bacterial identification of P. aeruginosa via 16S rRNA. Antimicrobial resistance (AMR) was detected either phenotypically using an antibiotic susceptibility test or genotypically with AMR resistance genes (ARGs) such as drfA, sul1, and ermB. P. aeruginosa was detected on dairy farms and households (10.3–57.5%, respectively), with an average of 23.2%. The resistance of dairy farm strains was observed against sulfamethoxazole, imipenem, cefepime, piperacillin–tazobactam, and gentamycin (100%, 72.7%, 72.7%, 68.8%, and 63.3%, respectively). Meanwhile, the resistance of household strains was observed against sulfamethoxazole, imipenem, amoxicillin, gentamicin, cefepime, and erythromycin by 91.3%, 82.6%, 75.4%, 75.4%, 68.1%, and 63.8%, respectively. The susceptibility of farm strains was detected against norfloxacin, ciprofloxacin, and levofloxacin (90.9%, 84.8%, and 72.7%, respectively). Meanwhile, the susceptibility of household strains was detected against ciprofloxacin, amikacin, and norfloxacin (100%, 84.1%, and 72.5%, respectively). About 81.4% of P. aeruginosa strains were MDR. ARGs (drfA, sul1, and ermB) were detected in farm strains (48.5%, 72.7%, and 24.4%, respectively) and household strains (50.7%, 72.5%, and 47.8%, respectively). Almost all P. aeruginosa had MAR over 0.2, indicating repeated application of antibiotics. P. aeruginosa prevalence was fivefold higher in households than on farms. MDR strains were higher amongst household strains than farm strains.
The Role of Catalyst Promotive Additives and Temperature in the Hydroisodewaxing Process
Authors: Abdildina Kamilla , Vassilina Gulzira , Abdrassilova Albina , Klassen Ivan A. , Orynbassar Raigul , Kanapiyeva Fatima
Published: November 2023

One of the valuable fractions of paraffinic oils is the diesel fraction, which can be used as a commercial fuel. However, the high content of alkanes of normal structure (~10–40%) in the diesel fraction leads to a deterioration in the performance characteristics of the fuel and, as a result, the inability to use the diesel fraction without additional processing in the cold season at lower temperatures, which is critical for many regions with cold winters. The process of catalytic dewaxing is one of the most promising ways to improve the low-temperature characteristics of diesel fractions. This work is devoted to studying the activity of promoted Ni, Mo, and Ni-Mo catalysts based on mesoporous aluminosilicate and pre-activated bentonite in dewaxing diesel fractions. The effect of the nature and content of promoting additives on the activity of bifunctional catalysts in the process of hydroisodewaxing of diesel fraction in a flow-type reactor in the temperature range of 260–340 °C, pressure of 2 MPa and feed space velocity of 1 h–1 was studied. It is shown that the synthesized bifunctional catalysts based on mesoporous aluminosilicate and pre-activated bentonite from the Tagan field (Ni/MAS-H-bentonite, Mo/MAS-H-bentonite, and Ni-Mo/MAS-H-bentonite) have the necessary balance of Lewis and Bronsted acid centers strengths. It allows them to selectively conduct the hydroisodewaxing process. It has been established that the use of the synthesized 5% Ni-1% Mo/MAS-H-bentonite bifunctional catalyst in the diesel fractions hydroisodewaxing process under optimal process conditions makes it possible to obtain diesel fuel with low-temperature characteristics that meet the requirements for cold climate fuels: cold filter plugging point (CFPP)—minus 33 °C, flash point in a closed cup—39 °C and pour point—minus 36 °C.
A Semi-Analytical Method for the S-Parameter Calculations of an N × M Multimode Interference Coupler
Authors: Moskalev Dmitrii , Kozlov Andrei , Salgaeva Uliana , Krishtop Victor , Perminov Anatolii V. , Venediktov Vladimir
Published: November 2023

A semi-analytical method for the S-parameter calculations of an N×M multimode interference coupler (MMI coupler) is presented. The proposed semi-analytical method is based on the mode decomposition and utilizes an effective index method to approximate the channel waveguide using an equivalent slab waveguide whose modes are described by exact analytic expressions. In comparison to the commonly used beam propagation method (BPM) and finite difference time domain method, which require significant time and computational resources, the proposed method accelerates the design process of photonic integrated circuits and basic building blocks such as an MMI coupler. The simulation results obtained using the developed method and the BPM were compared and showed very similar outcomes for different topologies of the MMI coupler. The key advantage of the proposed semi-analytical method over other analytical models is its ability to accurately simulate MMI couplers with an arbitrary position and number of input and output waveguides. In addition, this method can be extended using the theory of local coupled modes by taking into account the reflections from the end face of the MMI box.
Broadband 2.85 μm Luminescence Properties of Er3+/Dy3+ Co-Doped Fluorotellurite Glass
Authors: Bai Yuerong , Zhou Dechun , Cao Jilong , Cong Yuxuan , Wu Yuxiao
Published: November 2023

TeO2-BaF2-Er2O3-Dy2O3 laser glasses were prepared using the melt-quenching method. The bound water that can capture the excited state energy was reduced by physical and chemical methods. We did not observe a significant Er3+ emission peak at 2.7 μm in fluorescence spectra, which may be due to the efficient energy transfer process (ET2). Meanwhile, we found a broadband gain span of approximately 400 nm in fluorescence spectra at the 2.85 μm band, attributed to the ‘vector summation’ of the energy level radiation transition and the change of the glass network. Subsequently, we explored the structural properties of the glass. The results indicated that the Gaussian peak located at 250 cm−1 drifts toward 370 cm−1, which may be caused by the fracture or recombination of Te-O-Te and a decrease in the bridge oxygen content with the increasing concentration of Er2O3. The topology cage structure around the luminescence center of rare earth ions is changed and the stability of the optically active center is enhanced, finally contributing to the enhancement of luminescence. Meanwhile, the maximum σemi and gain coefficient of Dy3+ reach up to 7.22 × 10−21 cm2 and 7.37 cm−1, respectively. The comprehensive results show that the fluorotellurite glass designed in this study is expected to be a gain medium for mid-infrared lasers in remote sensing monitoring, military, and other fields.
The Features of the Optical Traps Formation Using Silicon Ring Gratings with Variable Height
Authors: Savelyev Dmitry A.
Published: November 2023

Features of the diffraction of Gaussian beams and Laguerre–Gaussian modes on subwavelength optical 3D microstructures with variable relief heights are calculated and studied in this paper. Silicon subwavelength ring gratings and diffraction axicons were considered as such optical microstructures. The height of individual relief elements varied. The propagation of laser light through the proposed optical elements was simulated using the finite difference time domain (FDTD) method. It was shown that it is possible to select the height of individual relief rings of ring gratings in such a way that it is possible to reduce the size of the focal spot down to 0.36 λ, form an extended light segment (up to 5.79 λ), and form optical traps.
Synthesis of Polyaluminum Chloride Coagulant from Waste Aluminum Foil and Utilization in Petroleum Wastewater Treatment
Authors: Youssef Hanan H. , Younis Sherif A. , El-Fawal Esraa M. , Ali Hager R. , Moustafa Yasser M. , Mohamed Gehad G.
Published: November 2023

This work investigates the potential synthesis of cost-effective polyaluminum chloride (PACl) coagulant from waste household aluminum foil and utilization for treating petroleum wastewater (PWW), especially dissolved organic compounds (DOC, like octanol–water mixture) and nonsettleable suspended (NSS-kaolin) mineral particles. Based on the Standard Practice for Coagulation–Flocculation Jar Test, the efficiency of PACl for DOC and NSS removal was evaluated in relation to the effects of the operational parameters. The results demonstrated that the as-prepared PACl has an amorphous morphology with a Keggin-type e-Al13 molecular structure {Na[AlO4(OH)24(H2O)]·xH2O and good thermal stability up to 278 °C. PACl coagulant also exhibited a higher efficiency for NSS removal than DOC by around 1.5- to 1.9-fold under broad pH (5–7), while a higher acidic/alkaline pH disrupts the sweep floc formation. An increased PACl dosage (over 25 mg/L) also caused a decrease in the coagulation efficiency by 11.7% due to Al species’ transformation and pH depression (from 6.8 to 4.9) via increased PACl hydrolysis. With a fast rotating speed of 280 rpm for 2 min, the minimum dose of PACl (10–25 mg/L) can maximize the removal efficiency of NSS (~98%) and DOC (~69%) at pH 6.5 ± 0.5 and 35 °C after 30 min of settling time. Treating actual saline PWW samples (salinity up to 187.7 g/L) also verified the high efficacy of PACl coagulation performance in reducing the turbidity and dissolved hydrocarbons by more than 75.5% and 67.7%, respectively. These findings verify the techno-economic feasibility of the as-prepared PACl coagulant in treating PWW treatment at different salinity levels.
Exploring Virtual Water Network Dynamics of China’s Electricity Trade: Insights into the Energy–Water Nexus
Authors: Lei Hang , Zhang Xin , Han Xinyi
Published: November 2023

The escalating challenges regarding the sustainable utilization of coupled energy and water resources require the implementation of synergistic management. Electricity-related virtual water flows could result in the transfer of freshwater vulnerability and environmental inequalities. Aiming to systematically characterize its holistic patterns, network structure and formation mechanisms, we constructed a virtual water network for electricity trade in China based on provincial lifecycle water footprints; portrayed the statistical features, structural stability and interregional equilibrium using Complex Network Analysis (CNA); and introduced the Quadratic Assignment Procedure (QAP) to gain socio-environmental insights into the driving factors. The results show that the virtual water transferred with China’s interprovincial electricity trade increased from 851.24 million m3 to 3441.58 million m3 from 2006–2020. Eastern, developed provinces with a high electricity demand have effectively relieved their water stress by expanding import sources, but the transfer of water resource benefits from western exporting regions (especially in the arid northern provinces) is irreversible. The current electricity market forces reflect the scarcity of energy and capital factors in the context of China’s interprovincial trade, but not the scarcity of water resources. Consequently, we proposed integrated management strategies including strengthening sectoral collaboration, optimizing energy-use structures and establishing ecological compensation mechanisms to build a more water-efficient future power system.
Cyanotoxin Analysis of Air Samples from the Great Salt Lake
Authors: Metcalf James S. , Banack Sandra Anne , Cox Paul Alan
Published: November 2023

The Great Salt Lake in Utah is the largest saline lake in the Western hemisphere and one of the largest terminal lakes in the world. Situated at the eastern edge of the Great Basin, it is a remnant of the freshwater Lake Bonneville whose water level precipitously lowered about 12,000 years ago due to a natural break in Red Rock pass to the north. It contains a diverse assemblage of cyanobacteria which vary spatially dependent on salinity. In 1984, the waters of the Great Salt Lake occupied 8500 km2. Nearly four decades later, the waters occupy 2500 km2—a reduction in surface area of 71%. With predominantly westerly winds, there is a potential for the adjacent metropolitan residents to the east to be exposed to airborne cyanobacteria- and cyanotoxin-containing dust. During the summer and fall months of 2022, air and dried sediment samples were collected and assessed for the presence of BMAA which has been identified as a risk factor for ALS. Collection of air samples equivalent to a person breathing for 1 h resulted in BMAA and isomers being found in some air samples, along with their presence in exposed lakebed samples. There was no clear relationship between the presence of these toxins in airborne and adjacent lakebed samples, suggesting that airborne toxins may originate from diffuse rather than point sources. These findings confirm that continued low water levels in the Great Salt Lake may constitute an increasing health hazard for the 2.5 million inhabitants of communities along the Wasatch Front.
Dengue Fever Complicated with Hemophagocytic Lymphohistiocytosis: A Case Report of Resolution with Steroid-Sparing Supportive Care
Authors: Mizutani Naoya , Kenzaka Tsuneaki , Nishisaki Hogara
Published: November 2023

Dengue fever (DF) can be complicated by hemophagocytic lymphohistiocytosis (HLH). Steroid administration is markedly effective for this hematologic complication, and for other viral infections. We present a rare case of DF-associated HLH that improved with steroid-sparing supportive care. A 47-year-old Japanese male with diabetes mellitus and no history of DF traveled to the Philippines 10 days before his hospitalization. Three days before emergency admission, he experienced fever and joint pain and was referred to our hospital for suspected DF, after blood tests indicated liver damage and thrombocytopenia. Erythema of the extremities and trunk appeared on day 2, and the next day neutrophils were 550 cells/μL, platelets 29,000 cells/μL, ferritin 9840 ng/mL, and fibrinogen 141 mg/dL. Bone marrow aspirate revealed hemophagocytic lymphohistiocytosis, and he was diagnosed with HLH. On day 4, the symptoms and findings improved; only supportive care without steroids was continued. He tested positive for dengue virus antigen on admission. He was discharged on day 9 of hospitalization in good general condition with no vascular leakage or bleeding and recovery of blood cells. Although steroid administration is markedly effective in cases of DF complicated by HLH, this case suggests that such cases can resolve with steroid-sparing supportive care.
Integrated and Sustainable Water and Sanitation Systems at Two Rural Sites in South Africa
Authors: Rudolph Michael John , Muchesa Evans
Published: November 2023

This paper presents a case study of two sites in South Africa: the Phumulani Agri-Village in Mpumalanga, and a school program in the Eastern Cape. The study evaluates the effectiveness of water and sanitation programs in these rural settings. A transdisciplinary literature review was conducted using primary and secondary data sources from the two sites. The data synthesized themes such as integrated water systems, agroecology, community participation, and resource use. The findings provide insights into the water and sanitation status and implementation of interventions. The application of integrated water systems demonstrated the effective use of rainwater harvesting and storage tanks, upgraded pit toilets, innovative stepped platforms, and stormwater retention methods. At Phumulani, old boreholes were repaired, and new ones were drilled, resulting in adequate water yield from five boreholes for agricultural projects and households, positively impacting the community. Plans to improve access and water quality are in place. These interventions underscore the importance of financial investment, human resources capability, infrastructure, and expertise in evaluation. The water systems have contributed to improved access to water, dignity, and health. Future objectives include containerized water treatment plants as sustainable solutions to ensure consistent, clean water for schools, households, agricultural projects, and eco-toilets.
MIGRANTŲ TAPATYBĖ IR LIETUVIŠKAS MAISTAS JUNGTINĖSE AMERIKOS VALSTIJOSE XX A.
Authors:   ,   Lietuvos istorijos institutas, Senulienė Jurgita
Published: November 2023

MIGRANT IDENTITY AND LITHUANIAN FOODWAYS IN THE UNITED STATES IN THE 20TH CENTURY Identity, according to the Lithuanian philosopher and American Lithuanian public figure Juozas Girnius, is a person’s ability to describe oneself as distinct from others by answering the question of “who am I?”, while also identifying one’s characteristics that relate one to a certain group, community, nation or institution. In most cases, one’s identity receives less attention when that person lives in their homeland or in a nationally homogenous environment where the same language is spoken or there is a belief in the same religion – many features of identity are created automatically, making them harder to notice. However, when departing one’s homeland to live in another country, according to Girnius, “when individual members [of a nation] find themselves in a foreign land” (Girnius 1961: 94) and lose the support of their community, the most important features of identity take on enormous significance, revealing themselves in a much more evident way, as the philosopher says, “self-determination emerges out of concern” (Girnius 1961: 94). Food, as one of the characteristics of a constructed identity, came to prominence in interwar Lithuania. In the strengthening and rapidly developing new state, the Lithuanian intelligentsia sought to become a part of the modern world, while also highlighting their own national culture and Lithuanian spirit (Jakubavičienė 2014: 265). It was during this period of national revival that ideas were raised not about the contours of a Polish, Russian, German or Jewish cuisine, nor the food eaten by the landed gentry as opposed to townspeople, but specifically a “truly Lithuanian” cuisine (Laužikas 2021: 13). The desire of wives and mothers to follow other nations was viewed with some skepticism, after all, “that which suits a rich Italian, French or English dinner table is very expensive and does not suit us because we have different customs” (Banaitienė et al. 1938: 116). The preservation of Lithuanian cuisine became important: “before long, our old dishes will disappear because foreign dishes are being introduced into our villages – schnitzels, fried pork cutlets, cvibelklopsai (fried then stewed beef fillets), fillets, etc.” (Čiapaitė-Mickienė 1936: 28), prompting household cooks to search for their own culinary identity: “we need our own, local culinary tradition suiting our health and lifestyles, both for everyday family meals and for celebrations and when serving guests” (Banaitienė et al. 1938: 116). Lithuania’s women were actively invited to take responsibility not only for making a Lithuanian cuisine a reality, but even for its inception: “we want our homemakers to not only be cooks, but creators” (Valatka 1935: 12). The act of making certain dishes and drinks and their consumption came to be considered as a declaration of ethnic identity.
Fulfillment of requirements for professional qualifications of employees in the hotel services sector by the example of a maid and a cook
Authors:   Kuban State University, Krasnodar, Russian Federation, Chamara I. A.
Published: November 2023

The article talks about the requirements for professional qualifications of workers in the hotel services sector.
Problems of protection of intellectual property in Russia
Authors:   FSAOU VO ", Dumikyan А. A. ,   Russian Peoples’ Friendship University",   named after Patrice Lumumba",   , Moscow, Russian Federation
Published: November 2023

Branding and protection of trademark rights are especially important for the hotel business. A trademark under the Civil Code of the Russian Federation is a designation with the help of which other people distinguish one hotel from another. Registration of a trademark is a guarantee that no one will use the brand name. The article is devoted to the study of legal contradictions in the legislative acts of the Russian Federation that regulate the activities of intellectual property objects. The author emphasizes that recently the regulatory framework has been improved, but legal contradictions remain.
Implementation of Vital Sign and Activity Guidelines for the Outpatient Therapist
Authors: Adler Joseph , Dekerlegand Jennifer
Published: November 2023

Background

Despite having training to assess vital signs (heart rate, blood pressure, and oxygen saturation), monitoring in outpatient therapy clinics is infrequent, and no guideline existed to support therapists. The goal of this project was to implement an evidence-based guideline in the outpatient therapy setting with the primary goal of improving patient safety by detecting asymptomatic, dangerously high blood pressure.

Methods

With stakeholder involvement across the organization, an evidence-based vital sign guideline was created and implemented across the 25 Good Shepherd Penn Partners outpatient therapy clinics (occupational, physical, and speech therapy) over a three-year period. Competency completion, volume of guideline-appropriate medical event reports, and documentation of vital signs were used to measure success.

Intervention

The interventions were studied in a phased approach over a three-year period and included therapist education and competency, assessment of guideline application and utilization, and knowledge translation to clinical practice.

Results

All outpatient therapists (N=185) completed the guideline education and competency within the expected six-month time period. A statistically significant increase in the number of medical events was reported across outpatient clinics, from six preceding implementation to 66 after project completion (p-value=0.02). Upon project completion, therapists correctly applied the guideline 94% of the time.

Conclusions

This project developed and implemented an evidence-based guideline to improve the consistency of blood pressure monitoring across our organization’s entire outpatient therapy service line. By substantially increasing blood pressure monitoring, we were able to proactively identify known or unknown abnormalities to positively impact patient safety in the ambulatory setting.
PRACTICAL JUSTIFICATION OF POSSIBILITY OF USING EXPERIMENTAL PROBIOTIC IN FEEDING DAIRY COWS
Authors: СМИРНОВА Ю.М. , ПЛАТОНОВ А.В. , СУРНАЧЕВА С.В. , ЛАПТЕВ Г.Ю.
Published: November 2023

Изучено влияние пробиотика «Румит» в кормлении коров черно-пестрой породы на уровень обменных процессов в их организме, плотность инфузорной фауны рубца и эффективность производства молока. Научно-хозяйственный эксперимент проведен в условиях Вологодской области. Были сформированы 2 группы коров черно-пестрой породы по 15 голов, подобранных методом сбалансированных групп с учетом кровности, номера лактации и уровня надоя за последнюю законченную лактацию, живой массы, количества дойных дней и среднесуточного удоя по текущей лактации. Животные в контрольной группе получали основной рацион, а в опытной в него был дополнительно включен изучаемый препарат из расчета 50 г на 1 голову в сутки. Продолжительность скармливания добавки составляла 90 дней. Установлено, что у коров опытной группы отмечено снижение в крови содержания общего белка на 13% (83,0 г/л; Р˂0,05), мочевины — на 19% (5,92 ммоль/л; Р˂0,05), билирубина — на 26% (1,74 мкмоль/л; Р˂0,01). Использование добавки способствовало повышению плотности инфузорий в рубце на 44,7%. От коров опытной группы за период эксперимента было получено на 9% больше молока. Дополнительная прибыль составила 37,61 руб. на 1 голову в сутки. Эти результаты подтверждают положительное влияние использования в кормлении ферментативно-пробиотического препарата, способствующего нормализации обменных процессов в организме, повышению плотности инфузорной фауны и экономической эффективности производства молока.

The impact of the probiotic “Rumit” in feeding the Russian Black Pied cattle on the level of metabolic processes in animal organisms, density of rumen infusoria fauna and milk production efficiency was studied. The scientific and agricultural experiment was conducted in the Vologda Oblast. Two groups of 15 Russian Black Pied cattle were formed, selected by the method of balanced groups, taking into account blood relationship, number and level of milk yield during the previous completed lactation, live weight, number of milking days and daily milk yield in the current lactation. Animals in the control group received a basic diet, and those in the experimental group received the preparation “Rumit” in addition to the basic diet at the rate of 50 grams per cow in a day. The duration of feeding the additive was 90 days. It was found that cows in the experimental group had a 13% (83.0 g/l) (Р˂0.05) decrease in total protein, 19% (5.92 mmol/l) (P˂0.05) decrease in urea, and 26% (1.74 mkmol/l) (P˂0.01) decrease in bilirubin in the blood. The use of the additive increased the density of infusoria in the rumen by 44.7%. During the experiment, 9% more milk was obtained from the cows of the experimental group, and, as a result, the additional profit was 37.61 rubles per head per day. These results confirm the positive impact of using the enzyme-probiotic preparation in feeding, as it helps to normalize metabolic processes in the body, increase the density of infusoria and economic efficiency of milk production.
Proyectos económicos y gestión de la política económica y productiva: experiencias recientes de gobiernos progresistas en América Latina
Authors: Kulfas Matías
Published: November 2023

Este artículo analiza los enfoques y rasgos centrales de política económica y productiva de seis gobiernos progresistas en América Latina: Argentina, Brasil, Bolivia, Chile, Colombia y México. El análisis atraviesa seis grandes ejes: la gestión macroeconómica, el posicionamiento en el escenario internacional, la articulación entre Estado y mercado, la gestión de los recursos naturales, la ampliación de la matriz productiva y las nuevas agendas de ambiente, género e igualdad. El estudio muestra que, si bien existen algunos puntos en común, también es posible hallar divergencias importantes, dificultades técnicas y políticas para avanzar en las agendas de reformas y logros parciales en las agendas productivas. De manera llamativa, las fuerzas que se autoperciben progresistas han tenido dificultades para estructurar un abordaje neodesarrollista, acorde con los desafíos del siglo XXI, con una prudente distancia tanto de los enfoques neoliberales como de los sesgos estatistas, persistiendo formas híbridas con resultados ambiguos y limitaciones.
Primary care clinicians’ perspectives on interacting with patients with gynaecological conditions: a systematic review
Authors: Briscoe Simon , Thompson Coon Jo , Melendez-Torres G J , Abbott Rebecca , Shaw Liz , Nunns Michael , Garside Ruth
Published: November 2023

Background

Studies have found that women with gynaecological conditions and symptoms do not feel listened to by primary care clinicians (PCCs). Less understood is whether PCCs perceive that there are challenges around listening to and interacting with this patient group.

Aim

To understand PCCs’ perspectives on the challenges of listening to and interacting with women patients with gynaecological conditions and symptoms.

Design & setting

Systematic review of English-language studies.

Method

We searched ASSIA (Applied Social Sciences Index and Abstracts), CINAHL (Cumulative Index to Nursing and Allied Health Literature), Embase, HMIC (Healthcare Management Information Consortium), and MEDLINE from inception to July 2023. We also conducted forward and backward citation searches of included studies. Identified records were screened independently by two reviewers. Data extraction was undertaken by one reviewer and checked by a second. Quality appraisal used the Wallace checklist. 'Best-fit' framework synthesis was used to synthesise findings around themes that explored the challenges of patient–clinician interaction.

Results

We identified 25 relevant articles. Perceived challenges associated with listening to and interacting with patients with gynaecological conditions and symptoms were identified at four ‘levels’: individual clinician level factors; structural and organisational factors; community and external factors; and factors related to gynaecological conditions. Interpretive analysis identified specific challenges relating to sociocultural factors affecting the consultation experience; the need for further education, training, or guidance for clinicians; factors affecting referral decisions; and factors related to service structure and organisation.

Conclusion

PCCs acknowledge that empathy, respect, and attentive listening are important when interacting with women patients with gynaecological conditions and symptoms. However, these ideals are impeded by several factors.
Encümen-i Şuarâ'da Şeyh Gâlib Etkisi
Authors: BOZKURT Gülümser
Published: November 2023

XIX. yüzyıl Türk edebiyatında önemli bir yeri olan Encümen-i Şuarâ, yenilik arayışındaki bir edebiyat zümresi olarak ara mertebeyi oluşturan bir şair topluluğudur. Sebk-i Hindî’yi şiirlerinde yansıtmaya çalışan, nazireciliği okula dönüştüren bu topluluk; hem kendi döneminde hem de kendinden önceki dönemde yetişmiş usta şairleri örnek almıştır. Divan şiirinin son büyük şairi Şeyh Gâlib de bu şairlerden biridir. Şeyh Gâlib’in kendi döneminde ve kendinden sonra yetişen şairler üzerinde, şairliğinin büyüklüğü kadar bir etkisi olmadığı görüşü mevcuttur. Bu çalışma, genel kanının aksine Şeyh Gâlib’in kendinden sonra yetişmiş şairlerde bir etkiye sahip olduğunu gösterme amacıyla ortaya çıkmıştır. Çalışmada Encümen-i Şuarâ’nın Şeyh Gâlib’e nazire şiirleri temel alınmıştır. Bu şairlerden; Leskofçalı Mustafa Galib Bey, Mehmed Lebib Efendi, İbrahim Hâlet Bey, Mûsâ Kâzım Bey, Osman Nûreddin Şems Efendi, Üsküdarlı İbrahim Hakkı Bey, Sâlih Fâik Bey, Hersekli Arif Hikmet Bey ve Memduh Fâik Bey’in gazellerinde Şeyh Gâlib’in gazellerine nazire olan şiirler fişlenmiştir. Fişleme sonucunda nazire şiirler, zemin şiirleri ile karşılaştırmalı olarak biçim ve içerik açısından değerlendirilmiştir. Çalışmanın sonucunda, Encümen-i Şuarâ’nın şiirlerinde Şeyh Gâlib etkisi ortaya konacaktır.
Educação pré-natal no Brasil: revisão integrativa
Authors: De Toledo Diego Aquino , Sá Luciana de Araújo , De Oliveira Márcia Farsura
Published: November 2023

A educação pré-natal (EP) tem uma variedade de benefícios para as mulheres e seus bebês durante o período perinatal.  Além disso, a aquisição de conhecimentos durante a gestação é indispensável para a melhoria da saúde materno-infantil e, portanto, deve ser preconizada. Dessa forma, objetivou-se revisar, na literatura científica, as temáticas e as metodologias exploradas nas atividades de educação em saúde sobre o pré-natal (PNA), parto e cuidados neonatais, voltadas às gestantes, no Brasil. Para isso, realizou-se revisão integrativa da literatura científica, nas bases de dados SciELO, LILACS e PubMed, no período compreendido entre 2018 e 2023, com os descritores e estratégias de busca: Educação em Saúde AND Educação Pré-Natal; Educação em Saúde AND Cuidado Pré-Natal; Health Education AND Prenatal Education e Health Education AND Prenatal Care. A análise de dez artigos identificou que a EP, com abordagem das temáticas preconizadas para esse período – alimentação e estilo de vida saudáveis, higiene, aleitamento, tratamento odontológico, IST, exames neonatais e parto – e dos assuntos demandados pelas gestantes, consiste em ferramenta viável para o melhor cuidado em saúde do binômio mãe-filho e para a alteração positiva dos indicadores de saúde. As principais metodologias utilizadas nas ações de EP são panfletagem, rodas de conversa, workshop, aplicativos móveis ou orientações realizadas durante as consultas seriadas do PNA.
Approach to synchronous liver metastases from colorectal carcinoma - results from a Portuguese reference center
Authors: Ruivo Ana Isabel da Silva , Monteiro Jéssica Alexandra Marques , Paiva Bárbara Oliveiros , Oliveira Rui Caetano , Martins Ricardo , Tralhão José Guilherme
Published: November 2023

About 15%-25% of patients with colorectal cancer, have synchronous liver metastases. The best surgical approach for the patients with asymptomatic primary colorectal tumor and synchronous liver metastases is still the subject of much debate. We aimed to evaluate the perioperative and long-term results as well as to identify possible prognostic factors of the two strategies:  liver- first and synchronous resection. Observational, retrospective study, which included patients with synchronous liver metastases from colorectal cancer, who underwent liver surgery between January 2016 and December 2021, in a Portuguese reference center. Patients were divided into two groups according to the therapeutic approach (synchronous resections vs Liver First) and into three groups according to the hepatic tumor burden (single liver lesion versus more than three liver lesions versus bilobar lesions). To determine the overall and disease-free survival, Kaplan-Meier curves and the log-rank test were performed and, to identify factors with an impact on the prognosis, a univariate and multivariate analysis were performed with the application of Cox regression (significance of 5%). Among the 46 patients included, 54,4% underwent the liver-first approach and 21 patients (45.7%) underwent simultaneous resection. The liver-first group had a greater number of patients with primary rectal tumor (84% vs.14.3%; p<0.001), with more than 3 hepatic lesions (56% vs.14%; p=0.004) and with more extensive hepatic resection. As for postoperative morbimortality, no statistically significant difference was observed between the two approaches (p=0.514). The median overall survival was similar even when considering the hepatic tumor burden (35.0 months (95%CI 15.91- 54.09) in the liver-first group vs. 48.0 months (95%CI 21.69-74.96) in the synchronous resection group; p=0.145). The same was observed for the median disease-free survival (16.0 months (95% CI 0-32.7) vs. 23.0 months (95% CI 16.3-29.7) p=0.651, respectively). The two strategies showed similar morbidity. No statistically significant difference was observed with regard to overall and disease-free survival even when the hepatic tumor burden was considered. One-year and three-year survival were also similar. However, it should be stressed that, the choice of the surgical approach for each group did not took into account the hepatic tumor burden, which we believe it is essential in choosing the best surgical approach.The existence of a multidisciplinary team is fundamental for the therapeutic success of these patients.
Mudanças nos padrões de morbimortalidade por insuficiência cardíaca nos pacientes hospitalizados do sistema único de saúde e seus impactos econômicos
Authors: Lins Matheus Manoel Diogo , Mello Victor Hugo Costa , Borges Vivian Fernandes Alves
Published: November 2023

A insuficiência cardíaca (IC) é uma síndrome complexa considerada via final comum de diversas doenças cardiovasculares e, dada sua alta prevalência é necessário a compreensão de seu perfil de morbimortalidade. Descrever o perfil da morbimortalidade por IC entre internações registradas no Departamento de Informática do Sistema Único de Saúde (DATASUS) e seu impacto na saúde pública entre 2008 e 2020. Estudo de cunho epidemiológico descritivo, com dados obtidos utilizando o aplicativo TABNET, desenvolvido pelo DATASUS. Foram incluídos pacientes de ambos os sexos, sem restrição de idade, que foram internados com o diagnóstico confirmado de IC no Brasil, durante o período de janeiro de 2008 a dezembro de 2020. Os dados foram estratificados considerando sexo, faixa etária, etnia/raça declarada, regime e caráter de atendimento. Durante o período estudado, 2.984.424 pacientes foram internados por IC no SUS. A maioria era do sexo masculino: 1.533.469 (51,38%); de idosos com faixa etária predominante entre 70 a 79 anos: 788.367 (26,41%); de etnia branca: 1.102.860 (36,95%); regime privado 1.196.559 (46,10%) e por caráter de atendimento de urgência 2.827.354 (94,73%). O valor médio de internação foi estimado em R$ 1.371,67 gerando um custo anual a economia brasileira de R$ 341.137.000. A insuficiência cardíaca é um importante problema de saúde pública, causando, além de uma elevada morbidade nas pessoas acometidas, um alto custo financeiro ao Sistema Único de Saúde (SUS).
Tumor edematoso de Pott (Pott‘s puffy tumor) em paciente pediatrico: um relato de caso
Authors: Da Silva Ellen Louisy Frazão , Albertoni André Luís , Dillon Renata de Araujo , De Oliveira Israel Santos , Santo Bianca Espirito , Da Silva Enoly Cristine Frazão , Sanches Thaís Rafael Almeida , Fragoso Vanine de Lourdes Aguiar Lima
Published: November 2023

Tumor de Pott é uma comorbidade rara caracterizada por um ou mais abscessos sub-periosteais do osso frontal as vezes associados a osteomielite subjacente. Fazer um relato de um caso de um paciente pediátrico com suspeita inicial de meningoencefalite que após minuciosa investigação foi diagnosticado com uma doença rara (tumor edematoso de Pott (Pott‘s Puffy tumor) não associado a osteomielite frontal. Trata-se de um levantamento de informações secundarias existentes no prontuário eletrônico (Idoctor) de um paciente, oriundo do interior do estado do Amazonas, internado no hospital referência em infectologia (alta em 2022) que após minuciosa investigação foi diagnosticado com uma doença rara. Paciente masculino, 12 anos, natural e oriundo do interior do estado, bastante choroso, queixando cefaleia, fonofobia e fotofobia intensa, com abaulamento de região frontal. Cervicalgia com rigidez local, sem sinais meníngeos (Kerning e Brudzinsk negativos). O exame do liquido cefalorraquidiano sem alteração. Foi realizada tomografia de crâneo que evidenciou um hematoma epidural em região frontal esquerda sugestivo de tumor de Pott. Devido a manutenção de estado febril após laudo e pareceres dos especialistas que indicavam abordagem cirúrgica para drenagem de empiema subdural, o paciente foi encaminhado para o hospital de referência em neurocirurgia para realização de procedimento cirúrgico. Foi realizada a cultura do material coletado (secreção purulenta) onde o resultado mostrou a presença de Serratia Marcescens e Staphylococcus epidermideis. Após procedimento a criança segue sem dor ou febre. Os exames de diagnóstico por imagem são recursos fundamentais para o conduta médica, acompanhamento de tratamento e prevenção de doenças tornando-se indispensáveis assim também como para o diagnóstico diferencial que possibilita novas alternativas diagnósticas, níveis de funcionamento ou a natureza da patologia, favorecendo uma melhor forma de possibilidade de tratamento.
Metemoglobinemia em paciente com Malária: relato de caso raro e potencialmente grave na Amazônia brasileira
Authors: De Melo Fernanda Araújo , De Castro Thiago Brito , Soares Carlos Gabriel de Souza , Melo Dessana Francis Chehuan , Aguiar Amanda França Silva
Published: November 2023

A malária por Plasmodium vivax tem uma importância global significativa e no Brasil, especialmente na região amazônica, o impacto na morbimortalidade é alto. Neste contexto, a Primaquina é um fármaco eficaz contra as formas que parasitam os hepatócitos, porém pode ser o responsável por quadros de metemoglobinemia que, apesar de incomum, é uma complicação grave e potencialmente fatal. O presente relato trata de um caso raro de metemoglobinemia em paciente potencialmente grave com malária por P. vivax após tratamento com antimalárico, na Amazônia brasileira.
Análise do perfil epidemiológico das internações de pacientes por complicações do Câncer de Cólon no estado do Piauí entre os anos de 2008 e 2021
Authors: Lima Isabelle Carvalho de Melo , E Silva Segundo Raylton Jansen , Bezerra Vitória de Sá
Published: November 2023

O câncer de cólon é uma doença comum e letal e trata-se do terceiro câncer mais prevalente em homens e o segundo mais prevalente em mulheres no mundo. Essa neoplasia maligna geralmente surge a partir de um adenoma que pode levar de 10 a 15 anos para se transformar em um câncer e, nesse intervalo de tempo, é possível fazer o rastreio do paciente por meio da identificação de lesões precoces ou localmente avançadas e ressecção destas e, portanto, prevenção e tratamento precoce do tumor. Tem-se por finalidade, ao longo desse estudo, traçar um perfil epidemiológico dos casos de internações de pacientes por câncer de cólon, especificamente no estado do Piauí entre os anos de 2008 e 2021, permitindo estabelecer discussões acerca dos dados coletados. A partir dos dados coletados é possível observar que a média de internações de pacientes devido problemas relacionados ao câncer de cólon foi de 424 casos, com um desvio padrão de 169, aproximadamente. O maior valor registrado para essas internações no estado do Piauí foi de 863 casos no ano de 2017, já o valor mínimo foi no ano de 2021, com 266 registros. Em relação à cor/raça, a maioria absoluta das internações por câncer de cólon foram em pessoas autodeclaradas pardas (94%). No que se refere ao sexo, a maioria dos casos de internação por câncer de cólon ocorreu em mulheres, apresentando 3330 registros, correspondendo a 56% do total, aproximadamente. No que tange à faixa etária, observa-se que os maiores valores são obtidos em pacientes idosos, principalmente na faixa etária de 60-69 anos, sendo registrado 1657 internações para essa faixa de idade, o que corresponde a 28% do valor total. Já no que tange aos gastos públicos por internações de pacientes devido câncer de cólon, Teresina lidera com um gasto total de mais de R$7800000,00 de reais no período de 2008 a 2021. Este estudo possibilitou a descrição do perfil dos pacientes internados acometidos com neoplasia maligna de cólon no estado do Piauí, mostrando-o bem semelhante com os dados publicados na literatura, sendo assim descritos: predominância do sexo feminino, idosos, e pacientes autodeclarados pardos. Os dados obtidos reforçaram a preponderância dos fatores ambientais para a patologia em questão, assim, torna-se necessária a instituição de aperfeiçoamentos no rastreamento dessa patologia, para, inclusive, tornar o tratamento mais efetivo, uma vez que a evolução da doença pode ser silenciosa e letal.
A eficácia da liraglutida no tratamento da obesidade - uma revisão integrativa
Authors: Fonseca Isabelle Felix , Borges Guilherme Dantas , Gonçalves Gabriel Carneiro , Moreira Filipe Portes , De Siqueira Emílio Conceição
Published: November 2023

A taxa de obesidade em adultos e a prevalência de sobrepeso e obesidade entre crianças são crescentes, sugerindo um aumento de comorbidades relacionadas a obesidade. Nesse sentido, se faz necessária a implantação de medidas eficazes para o combate da obesidade e consequente redução das doenças por ela desencadeadas. E, nesse contexto, surgem as drogas antiobesidade como a Liraglutida que teve sua efetividade demonstrada no tratamento do diabetes, entretanto poucos estudos avaliaram sua eficácia na perda de peso. Desta forma, o objetivo dessa revisão de literatura foi analisar a eficácia da liraglutida no tratamento da obesidade em diferentes contextos de saúde. Para realização do artigo foram utilizadas as bases de dados National Library of Medicine (PubMed) e a Biblioteca Virtual em Saúde -Brasil (BVS-Brasil). A busca foi realizada com as palavras chave “liraglutide”,”obesity” e “treatment effectiveness”,sendo a busca da seguinte forma: “liraglutide” and “ obesity” and “treatment effectiveness” . Como critérios de inclusão foram utilizados texto completo gratuito e do tipo ensaio clinico controlado, publicados entre 2015 e 2022. Já os critérios de exclusão utilizados foram fuga ao tema, artigos que não eram do tipo ensaio clínico e artigos duplicados. Após a aplicação dos critérios de inclusão e exclusão, seguida da leitura dos trabalhos, foram selecionados 18 artigos do PubMed e 4 artigos do BVS-Brasil, resultando em um total de 22 artigos. Os resultados desse estudo mostraram que em todos os 22 estudos analisados, a liraglutida se mostrou como um medicamento eficaz nos indivíduos obesos assim como nos obesos portadores de Diabetes, com diminuição significativa do peso. Em conclusão, sugere-se que o uso desse fármaco como medida para controle da obesidade e sobrepeso é eficaz nos diferentes contextos de saúde analisados.