bluuebunny/crossref_metadata_2025 huggingface dataset:
Educating Peasants: the Beibei Public Library in Light of Chinese Rural Reconstruction, 1928–1950
Authors: Jiale Ren , Leye Yao , Chunyu Liu
Published: May 2019

The Beibei Public Library (1928–1950) dedicated itself to social education in the rural areas of Chongqing. Examining this library in light of rural reconstruction, this study considers how libraries are affected by the attitudes and behaviors of social elites, officials, government policies, wars, conventional thinking etc. The Beibei Public Library is studied in terms of three aspects: indoor service, itinerant libraries, and additional services. Moreover, this study examines how librarians catered to peasants’ needs, promoted knowledge dissemination, and helped mold new lifestyles in rural China. This case study contributes to research on Chinese rural libraries in the first half of the twentieth century.
Expanding Academic Librarians’ Roles in the Research Life Cycle
Authors: Nitecki Danuta A. , Davis Mary Ellen K.
Published: May 2019

Research depends on prior results. The cycle of transforming research output to disseminated knowledge is changing to engage more researchers to openly discover and thereby shape future contributions to scholarship. No established framework helps librarians understand the opportunities that transition offers librarians. However, through four propositions, this paper addresses some of the changes facing academic librarians as they expand their roles: 1) Research cycles embrace interactive sharing and reuse of data; 2) Managing open research data expands librarians’ roles; 3) Intellectual entrepreneurship roles provide a model to empower others; 4) Librarians demonstrate their entrepreneurial leadership by creating partnerships outside the library. Now academic librarians have opportunities to strengthen their role in how higher education shapes research by shifting greater focus toward research data management [RDM]. Two seasoned administrators and librarians illustrate pathways to prepare academic librarians for these new roles. They offer two practitioners’ impressions of the demands and opportunities for librarians to extend their expertise to support RDM, and illustrate how academic librarians have begun doing so through professional association work (through the Association of College and Research Libraries (ACRL)) and at one academic library (at Drexel University). They urge academic librarians to step out of their comfort zones of organizing, preserving and servicing discovery of information resources and embrace emerging roles for which their values and expertise have prepared them. If librarians ignore these opportunities, they risk being bypassed in efforts to ensure that managing research data and scholarship are central to research protocols.
Measurement of the laser resonance ionization efficiency for lutetium
Authors: Gadelshin Vadim Maratovich , Heinke Reinhard , Kieck Tom , Kron Tobias , Naubereit Pascal , Rösch Frank , Stora Thierry , Studer Dominik , Wendt Klaus
Published: May 2019

The development of a highly efficient resonance ionization scheme for lutetium is presented. A laser ion source, based on the all-solid-state Titanium:sapphire laser system, was used at the 30 keV RISIKO off-line mass separator to characterize different possible optical excitation schemes in respect to their ionization efficiency. The developed laser resonance ionization scheme can be directly applied to the use at radioactive ion beam facilities, e. g. at the CERN-MEDICIS facility, for large-scale production of medical radioisotopes.
Epiepistemology/neuro-semantic programming
Authors: Chong Jennifer K. , Chong Dennis
Published: May 2019

It is a mystery how we just know to be in any context of our lives. It happens without our thinking. By this same token we never have to work out how to speak an English sentence that we utter. We just know to talk and do. This paper is an exploration of this mystery.
Perelman’s phenomenology of rhetoric: Foucault contests Chomsky’s complaint about media communicology in the age of Trump polemic
Authors: Lanigan Richard L.
Published: May 2019

The analysis explores the main arguments of Noam Chomsky’s short book,Media Controlthat also reprints the monograph “The Journalist from Mars: How the ‘War on Terror’ Should Be Reported.” The problematic is Aristotelian rhetoric and Enlightenment rationality (justice) in civic discourse (Lógos) as compared to the thematic of dialogic reasonableness (Eulógos). Chomsky’s assumption of, and critique of, “old rhetoric” [Aristotle’srhētorikḗ] is followed by a discussion of Chiam Perelman’s “new rhetoric” [presocraticpoiētikḗ/epideiktikos / gērys] and his “incarnate adherence” (givingvoiceto) concept of the Universal Audience as a function of Epideictic argumentation. This is also a critique of Stephen Toulman’s neo-Aristotelian model of rhetorical “warrant” and its connection to Charles S. Peirce’s normative semiotic of the “argument cycle.” Heidegger’s and Lakoff’s concept of discourse framing is associated with Michel Foucault’s rhetoric concept of an ethic of social discourse for the common good (parrhesia) in the age of Umberto Eco’s hyperreality media that displays Baudrillard’s simulacra, such as Donald Trump.
Evaluation of anti-adipogenic active homoisoflavonoids from Portulaca oleracea
Authors: Lee Jung Im , Oh Jung Hwan , Kong Chang-Suk , Seo Youngwan
Published: May 2019

This study was performed to isolate antiobesity components from the crude extract of Portulaca oleracea. The crude extract was partitioned into n-hexane, 85% aqueous methanol, n-butanol, and water fractions. Their effects on adipogenic differentiation were evaluated in 3T3-L1 cells. Among the solvent fractions from P. olearacea, the 85% aq. MeOH effectively reduced the levels of lipid accumulation. Further purification of 85% aq. MeOH led to the isolation of the known homoisoflavonoids 1–4, as the active substances. The administration of homoisoflavonoids to adipocyte cells decreased the lipid accumulation and glucose consumption and increased the release of glycerol into culture medium. In particular, homoisoflavonoid 3 effectively down-regulated the adipogenic transcription genes such as peroxisome proliferator activated receptor-γ (PPARγ) and CCAAT/enhancer-binding proteins (C/EBPα), and adipogenic target genes such as fatty acid binding protein 4 (FABP4), fatty acid transport protein 1 (FATP1), and acyl-CoA synthase 1 (ACS1).
Little hospital on the South Common: A history of the Victoria General Hospital
Authors: Wong Mike
Published: May 2019

.
Severe thrombocytopenia in an adolescent caused by Epstein Barr Virus
Authors: Formosa Amanda , Haase David
Published: May 2019

.
Severe hypokalaemia in diabetic ketoacidosis: a contributor to central pontine myelinolysis?
Authors: Chinoy A , Wright N B , Bone M , Padidela R
Published: May 2019

Hypokalaemia at presentation of diabetic ketoacidosis is uncommon as insulin deficiency and metabolic acidosis shifts potassium extracellularly. However, hypokalaemia is a recognised complication of the management of diabetic ketoacidosis as insulin administration and correction of metabolic acidosis shifts potassium intracellularly. We describe the case of a 9-year-old girl with newly diagnosed type 1 diabetes mellitus presenting in diabetic ketoacidosis, with severe hypokalaemia at presentation due to severe and prolonged emesis. After commencing management for her diabetic ketoacidosis, her serum sodium and osmolality increased rapidly. However, despite maximal potassium concentrations running through peripheral access, and multiple intravenous potassium ‘corrections’, her hypokalaemia persisted. Seventy two hours after presentation, she became drowsy and confused, with imaging demonstrating central pontine myelinolysis – a rare entity seldom seen in diabetic ketoacidosis management in children despite rapid shifts in serum sodium and osmolality. We review the literature associating central pontine myelinolysis with hypokalaemia and hypothesise as to how the hypokalaemia may have contributed to the development of central pontine myelinolysis. We also recommend an approach to the management of a child in diabetic ketoacidosis with hypokalaemia at presentation.

Learning points:

Hypokalaemia is a recognised complication of treatment of paediatric diabetic ketoacidosis that should be aggressively managed to prevent acute complications.

Central pontine myelinolysis is rare in children, and usually observed in the presence of rapid correction of hyponatraemia. However, there is observational evidence of an association between hypokalaemia and central pontine myelinolysis, potentially by priming the endothelial cell membrane to injury by lesser fluctuations in osmotic pressure.

Consider central pontine myelinolysis as a complication of the management of paediatric diabetic ketoacidosis in the presence of relevant symptoms with profound hypokalaemia and/or fluctuations in serum sodium levels.

We have suggested an approach to the management strategies of hypokalaemia in paediatric diabetic ketoacidosis which includes oral potassium supplements if tolerated, minimising the duration and the rate of insulin infusion and increasing the concentration of potassium intravenously (via central line if necessary).
Development of Nationwide Recommendations to Support Prenatal Counseling in Extreme Prematurity
Authors: Geurtzen Rosa , van Heijst Arno F.J. , Draaisma Jos M.T. , Kuijpers Lindie J.M.K. , Woiski Mallory , Scheepers Hubertina C.J. , van Kaam Anton H. , Oudijk Martijn A. , Lafeber Harrie N. , Bax Caroline J. , Koper Jan F. , Duin Leonie K. , van der Hoeven Marc A. , Kornelisse René F. , Duvekot Johannes J. , Andriessen Peter , van Runnard Heimel Pieter J. , van der Heide-Jalving Marja , Bekker Mireille N. , Mulder-de Tollenaer Susanne M. , van Eyck Jim , Eshuis-Peters Ellis , Graatsma Margo , Hermens Rosella P.M.G. , Hogeveen Marije
Published: May 2019

OBJECTIVES:

To develop a nationwide, evidence-based framework to support prenatal counseling in extreme prematurity, focusing on organization, decision-making, content, and style aspects.

METHODS:

A nationwide multicenter RAND–modified Delphi method study was performed between November 2016 and December 2017 in the Netherlands. Firstly, recommendations were extracted from literature and previous studies. Secondly, an expert panel (n = 21) with experienced parents, obstetricians, and neonatologists rated the recommendations on importance for inclusion in the framework. Thirdly, ratings were discussed in a consensus meeting. The final set of recommendations was approved and transformed into a framework.

RESULTS:

A total of 101 recommendations on organization, decision-making, content, and style were included in the framework, including tools to support personalization. The most important recommendations regarding organization were to have both parents involved in the counseling with both the neonatologist and obstetrician. The shared decision-making model was recommended for deciding between active support and comfort care. Main recommendations regarding content of conversation were explanation of treatment options, information on survival, risk of permanent consequences, impossibility to predict an individual course, possibility for multiple future decision moments, and a discussion on parental values and standards. It was considered important to avoid jargon, check understanding, and provide a summary. The expert panel, patient organization, and national professional associations (gynecology and pediatrics) approved the framework.

CONCLUSIONS:

A nationwide, evidence-based framework for prenatal counseling in extreme prematurity was developed. It contains recommendations and tools for personalization in the domains of organization, decision-making, content, and style of prenatal counseling.
THE EFFECT OF THE EXERCISE PROGRAMS ON THE BOY’S SELF-CONCEPT
Authors: Dr. Pham Thi Le Hang
Published: May 2019

This study is to investigate the effectiveness of an exercise program for children from10 to 11 years old. In this study, 30 subjects were divided into two groups of equalcontrol and training. After completing the procedure, the participants in the traininggroup performed the gymnastics training program for 12 weeks and the controlgroup did nothing. Data collection tool is a demographic questionnaire and a scale ofself-concept Piers-Harris. Kolmogorov-Smirnov test is used to test the normal distributionof samples. The research results show that in the training group, the size ofthe concept of self and the general self concept of children before and after exerciseinstrument increased significantly. The results also show that the size of happinessand satisfaction of children, both in the control group and in the training group, issignificantly different. The study, concluded that a training program in the field ofgymnastics training has significantly increased the level of self-concept of children.
Relational Ritual Politeness and Self-display in Historical Chinese Letters*
Authors: Kádár Dániel Z.
Published: May 2019

This paper delivers an interdisciplinary approach to historical Chinese epistolary data, by examining the language and style of historical Chinese letters from the perspective of linguistic pragmatics, historical politeness research and relational ritual theory. It argues that various discursive characteristics of Chinese epistles, which previous Sinological research has identified, may be systematically modelled if one approaches historical Chinese letter writing as a ritual practice. Language use in historical Chinese letters tends to have a strongly ritual character, due to two reasons. First, Chinese epistles represent interpersonal interaction in a sociocultural context that triggered intensive ritual politeness. Second, many literati regarded letter writing as an activity of fine art by means of which one could ritually display one’s epistolary skill. Owing to this, the language of historical Chinese epistles features a duality of (1) other-oriented ritual politeness and (2) self-oriented ritual display. The present paper examines this duality by setting up an analytic model, and by investigating a renowned corpus of Qing Dynasty letters, Xuehongxuan chidu 雪鴻軒尺牘 (Letters from Snow Swan Retreat).
Alterations in functional networks during cue-reactivity in Internet gaming disorder
Authors: Ma Shan-Shan , Worhunsky Patrick D. , Xu Jian-song , Yip Sarah W. , Zhou Nan , Zhang Jin-Tao , Liu Lu , Wang Ling-Jiao , Liu Ben , Yao Yuan-Wei , Zhang Sheng , Fang Xiao-Yi
Published: May 2019

Background

Cue-induced brain reactivity has been suggested to be a fundamental and important mechanism explaining the development, maintenance, and relapse of addiction, including Internet gaming disorder (IGD). Altered activity in addiction-related brain regions has been found during cue-reactivity in IGD using functional magnetic resonance imaging (fMRI), but less is known regarding the alterations of coordinated whole brain activity patterns in IGD.

Methods

To investigate the activity of temporally coherent, large-scale functional brain networks (FNs) during cue-reactivity in IGD, independent component analysis was applied to fMRI data from 29 male subjects with IGD and 23 matched healthy controls (HC) performing a cue-reactivity task involving Internet gaming stimuli (i.e., game cues) and general Internet surfing-related stimuli (i.e., control cues).

Results

Four FNs were identified that were related to the response to game cues relative to control cues and that showed altered engagement/disengagement in IGD compared with HC. These FNs included temporo-occipital and temporo-insula networks associated with sensory processing, a frontoparietal network involved in memory and executive functioning, and a dorsal-limbic network implicated in reward and motivation processing. Within IGD, game versus control engagement of the temporo-occipital and frontoparietal networks were positively correlated with IGD severity. Similarly, disengagement of temporo-insula network was negatively correlated with higher game-craving.

Discussion

These findings are consistent with altered cue-reactivity brain regions reported in substance-related addictions, providing evidence that IGD may represent a type of addiction. The identification of the networks might shed light on the mechanisms of the cue-induced craving and addictive Internet gaming behaviors.
Exercise addiction and its related factors in amateur runners
Authors: Lukács Andrea , Sasvári Péter , Varga Beatrix , Mayer Krisztina
Published: May 2019

Background and aims

This study examines exercise addiction (EA) in amateur runners from a multidimensional approach, including demographics (age, sex, educational attainment, and financial situation), training factors (duration of running activity, weekly time spent running, mean workout distance per session, other sports activities, and childhood physical activity), psychological features (perceived health, life satisfaction, loneliness, stress, anxiety, depression, body shape, and eating disorders), and anthropometrics (body mass index) that might predict EA.

Methods

The well-validated Exercise Dependence Scale (EDS) was applied to evaluate the prevalence of EA in amateur runners. A multinomial logistic regression was performed to find explanatory variables of risk of EA using the SPSS 24.0 statistical software.

Results

A total of 257 runners (48.9% females, Mage = 40.49, SD = 8.99 years) with at least 2 years running activity participated in an anonymous questionnaire survey. About 53.6% of respondents were characterized as non-dependent symptomatic and 37.8% as non-dependent asymptomatic. About 8.6% had prevalence of being at risk of EA. The logistic regression model displayed five variables that significantly predicted the risk of EA: (a) anxiety, (b) loneliness, (c) weekly time spent running, (d) childhood physical activity, and (e) education level.

Discussion and conclusions

Findings indicate that loneliness and anxiety may lead to withdrawal and uncontrolled behavior that in turn leads to increased amount of exercise in amateur runners. Lower level of education attainment is also a likely risk of EA development, and childhood sports activity is a predictor.
Selection of Cluster Heads for Wireless Sensor Network in Ubiquitous Power Internet of Things
Authors: Hu Wei , Yao Wenhui , Hu Yawei , Li Huanhao
Published: May 2019

This paper designs a selection algorithm of cluster heads (CHs) in wireless sensor network (WSN) under the ubiquitous power Internet of Things (UPIoT), aiming to solve the network failure caused by premature death of WSN sensors and overcome the imbalance in energy consumption of sensors. The setting of the cluster head node helps to reduce the energy consumption of the nodes in the network, so the choice of cluster head is very important. The author firstly explains the low energy adaptive clustering hierarchy (LEACH) and the distance and energy based advanced LEACH (DEAL) protocol. Compared with the LEACH, the DEAL considers the remaining nodal energy and the sensor-sink distance. On this basis, the selectivity function-based CH selection (SF-CHs) algorithm was put forward to select CHs and optimize the clustering. Specifically, the choice of CHs was optimized by a selectivity function, which was established based on the remaining energy, number of neighbors, motion velocity and transmission environment of sensors. Meanwhile, a clustering function was constructed to optimize the clustering, eliminating extremely large or small clusters.Finally, the simulation proves that the DEAL protocol is more conducive to prolonging the life cycle of the sensor network. The SF-CHs algorithm can reduce the residual energy variance of nodes in the network, and the network failure time is later, which provides a way to improve the stability of the network and reduce energy loss.
Phase II, Multicenter, Randomized Trial of Docetaxel plus Prednisone with or Without Cediranib in Men with Chemotherapy-Naive Metastatic Castrate-Resistant Prostate Cancer
Authors: Heath Elisabeth , Heilbrun Lance , Mannuel Heather , Liu Glenn , Lara Primo , Monk J. Paul , Flaig Thomas , Zurita Amado , Mack Philip , Vaishampayan Ulka , Stella Philip , Smith Daryn , Bolton Susan , Hussain Arif , Al-Janadi Anas , Silbiger Daniel , Usman Muhammad , Ivy S. Percy
Published: May 2019

Lessons Learned

The negative results are consistent with the negative results of large phase III trials in which docetaxel plus antiangiogenic agents were used in patients with metastatic castrate-resistant prostate cancer (mCRPC). The negative data underscore that, despite a sound biological rationale and supportive early-phase clinical results, adding antiangiogenic agents to docetaxel for mCRPC is a great challenge.

Background

Inhibition of vascular endothelial growth factor (VEGF) signaling abrogates tumor-induced angiogenesis to constrain tumor growth, and can be exploited therapeutically by using cediranib, an oral tyrosine kinase inhibitor of VEGF receptor signaling. Our preliminary phase I trial data showed that adding cediranib to docetaxel plus prednisone (DP) was safe and feasible, with early evidence for efficacy in patients with metastatic castrate-resistant prostate cancer (mCRPC).

Methods

This multicenter phase II trial assessed whether adding cediranib to DP improves efficacy of DP in patients with mCRPC. Chemotherapy-naive patients with mCRPC were randomly assigned to receive either docetaxel (75 mg/m2 intravenously every 3 weeks) with prednisone (5 mg twice daily) plus cediranib (30 mg once daily; the DP+C arm) or DP only (the DP arm). The primary endpoint was to compare 6-month progression-free survival (PFS) rate between the two arms. Secondary endpoints included 6-month overall survival (OS), objective tumor and prostate-specific antigen (PSA) response rates, biomarkers, and adverse events.

Results

The 6-month PFS rate in a total of 58 patients was only numerically higher in the DP+C arm (61%) compared with the DP arm (57%). Similarly, the 6-month OS rate, objective tumor and PSA response rates, and biomarkers were not significantly different between the two arms. Increased baseline levels of interleukin 6 (IL-6), however, were significantly associated with increased risk of progression. Neutropenia was the only grade 4 toxicity (38% in the DP+C arm vs. 18% in the DP arm).

Conclusion

Combining cediranib with docetaxel + prednisone failed to demonstrate superior efficacy, compared with docetaxel + prednisone, and added toxicity. Our data do not support pursuing the combination further in patients with mCRPC.
Changes in Albuminuria But Not GFR are Associated with Early Changes in Kidney Structure in Type 2 Diabetes
Authors: Looker Helen C. , Mauer Michael , Saulnier Pierre-Jean , Harder Jennifer L. , Nair Viji , Boustany-Kari Carine M. , Guarnieri Paolo , Hill Jon , Esplin Cordell A. , Kretzler Matthias , Nelson Robert G. , Najafian Behzad
Published: May 2019

Significance Statement

Although diabetic nephropathy is assessed clinically by measuring eGFR and albuminuria, structural kidney damage typically precedes these clinical manifestations. Previous studies have assessed early structural change in type 1 diabetes but not in type 2. In a study of American Indian patients with type 2 diabetes and generally preserved kidney function, the authors found changes in kidney structure over an average of 9 years, as determined by quantitative morphometric analysis of kidney biopsy specimens. They also found that these kidney structure changes were more consistently associated with changes in albuminuria than with changes in measured GFR. This finding suggests that for people with normal or elevated GFR, increasing albuminuria may better than early GFR decline in reflecting the risk of progressive type 2 diabetic nephropathy.

Background

In type 1 diabetes, changes in the GFR and urine albumin-to-creatinine ratio (ACR) are related to changes in kidney structure that reflect disease progression. However, such changes have not been studied in type 2 diabetes.

Methods

Participants were American Indians with type 2 diabetes enrolled in a clinical trial of losartan versus placebo. We followed a subset who underwent kidney biopsy at the end of the 6-year trial, with annual measurements of GFR (by urinary clearance of iothalamate) and ACR. Participants had a second kidney biopsy after a mean follow-up of 9.3 years. We used quantitative morphometric analyses to evaluate both biopsy specimens.

Results

Baseline measures for 48 participants (12 men and 36 women, mean age 45.6 years) who completed the study included diabetes duration (14.6 years), GFR (156 ml/min), and ACR (15 mg/g). During follow-up, glomerular basement membrane (GBM) width, mesangial fractional volume, and ACR increased, and surface density of peripheral GBM and GFR decreased. After adjustment for sex, age, ACR, and each morphometric variable at baseline, an increase in ACR during follow-up was significantly associated with increases in GBM width, mesangial fractional volume, and mean glomerular volume, and a decrease in surface density of peripheral GBM. Decline in GFR was not associated with changes in these morphometric variables after additionally adjusting for baseline GFR.

Conclusions

In American Indians with type 2 diabetes and preserved GFR at baseline, increasing ACR reflects the progression of earlier structural glomerular lesions, whereas early GFR decline may not accurately reflect such lesions.
Desdobramentos da financeirização e o seu impacto sobre o crescimento econômico brasileiro (1996-2017)
Authors: Attílio Luccas Assis , Mendes Bruno Ramon Martins
Published: May 2019

Esse artigo investiga a financeirização da economia brasileira e o seu impacto sobre o crescimento econômico. Utiliza-se o índice de Bruno et al. (2009) para retratar a financeirização, o qual é formado pela diferença do agregado monetário M4 pelo agregado monetário M1 dividida pela formação bruta de capital fixo. Percebe-se que esse indicador se expandiu ao longo do tempo, sugerindo a expansão da financeirização. Posteriormente, para captar a influência da financeirização sobre o crescimento econômico entre os anos 1996 e 2017, utiliza-se o VEC e, por meio da relação de longo prazo entre as variáveis (cointegração), e pela função impulso resposta (FIR), conclui-se que a financeirização se relaciona de forma negativa com o crescimento econômico.
EKSTRAKSI KONSENTRAT NEODIMIUM MEMAKAI TRI OKTIL AMIN THE EXTRACTION OF NEODYMIUM CONCENTRATES USING TRI OCTYL AMINE
Authors: Purwani MV , . Prayitno
Published: May 2019

Telah dilakukan ekstraksi konsentrat Nd hasil olah pasir monasit. Tujuan penelitian ini memisahkan Nd dari pengotornya : Y, Ce dan La. Sebagai fasa air adalah konsentrat Nd(OH)3 dalam HNO3 dan sebagai ekstraktan atau fasa organik adalah tri oktil amin (TOA) dalam kerosen. Variabel yang diteliti konsentrasi HNO3, konsentrasi umpan, konsentrasi TOA dalam kerosen, waktu pengadukan dan kecepatan pengadukan. Dari hasil penelitian optimasi proses ekstraksi neodimium dari konsentrat Nd(OH)3 hasil olah pasir monasit dengan ekstraktan TOA, diperoleh kesimpulan sebagai berikut: konsentrasi HNO3 yang optimum 2M, konsentrasi umpan 5 gram/10 mL, konsentrasi TOA dalam kerosen 6 %, waktu pengadukan yang optimum 15 menit, kecepatan pengadukan 200 rpm. Pada kondisi ini diperoleh Kd Nd = 0,56; efisiensi ekstraksi Nd = 35,70%; FP Nd-La = ≈6,48; FP Nd-Ce = 3,72 dan FP Nd-Y = 1,38.Kata kunci : ekstraksi, tri oktil amin (TOA), neodimium ≈
Fabrication of a ZnO/PDMS Piezoelectric Triboelectric Nanogenerator v1
Authors: Perez Carlos , Perez-Taborda Ja , Avila Alba
Published: May 2019

This protocol presents the fabrication process for a piezoelectric triboelectric nanogenerator (PTNG) using commercially available materials.
Inmunopatología del dengue: importancia y participación de los monocitos y sus subpoblaciones
Authors: Naranjo-Gómez Juan Sebastián , Castillo-Ramírez Jorge Andrés , Velilla-Hernández Paula Andrea , Castaño-Monsalve Diana Maria
Published: May 2019

El dengue es una infección viral aguda transmitida por la picadura de mosquitos del género Aedes, la cual produce hasta 100 millones de infecciones anuales en el mundo. Una gran proporción de individuos infectados con el virus presentan infecciones asintomáticas. Sin embargo, de los individuos que desarrollan la enfermedad, el 95 % presentan signos y síntomas similares a una virosis común, que por lo general se autoresuelven (dengue con y sin signos de alarma). El 5 % restante puede evolucionar a manifestaciones graves, caracterizadas por hemorragias, daño orgánico, choque hipovolémico e incluso la muerte (dengue grave).Los monocitos son uno de los blancos principales de la infección producida por el virus del dengue (DENV), los cuales participan en la replicación del mismo y en la producción de una gran variedad de citoquinas que contribuyen con el daño de diferentes tejidos y órganos en respuesta a la infección. Los monocitos se dividen en tres subpoblaciones: clásica (CD14++CD16-), no clásica (CD14+CD16++) e intermedia (CD14++CD16+), las cuales poseen respuestas funcionales contrastantes en diferentes procesos inflamatorios, en cuanto a la producción de mediadores solubles e interacción con el endotelio. Los monocitos no clásicos parecen ser los principales productores de mediadores inflamatorios como el TNF-α y la IL-1β en respuesta a la infección por DENV. Por lo tanto, se propone que cada subpoblación de monocitos debe tener un papel diferencial en la inmunopatología de la enfermedad.En esta revisión se recopilan los principales aspectos de la replicación viral y la inmunopatología del dengue, así como los principales hallazgos referentes al papel de los monocitos en esta infección y además, se propone un papel potencial y diferencial de las subpoblaciones de monocitos.
Estaciones automatizadas preanalíticas en el laboratorio de hemostasia. Estudio observacional descriptivo prospectivo, realizado en un hospital universitario de referencia entre el 15 de abril y 15 de julio de 2017
Authors: Sua Luz Fernanda , Amézquita María Alejandra , Hernández Daniel Esteban , Alcalá-Flores Mercedes , Leib Carl Sebastian , Aguirre-Rojas Marisol , Fernández-Trujillo Liliana
Published: May 2019

Introducción: los errores del proceso de análisis de las muestras del laboratorio clínico, impactan negativamente a la práctica médica, la seguridad del paciente e incrementan los costos de atención en la salud. El uso de estaciones automatizadas demostró una disminución de los errores en los laboratorios clínicos de inmunoquímica y hematología. Se propone comparar las primeras estaciones automatizadas de hemostasia con el método manual para determinar los interferentes en las muestras de cinco servicios del hospital durante tres meses.Métodos: estudio observacional descriptivo prospectivo de corte trasversal. Las muestras que ingresaron al laboratorio clínico fueron analizadas por la estación automatizada y el método manual. Las interferentes bilirrubinas, hemoglobina, lipemia, volumen de llenado del tubo y obstrucción fluídica-coágulo se estudiaron con ambos métodos. Se realizó el análisis estadístico y se calculó el índice kappa para determinar la fuerza de la concordancia entre los métodos.Resultados: de 8.970 muestras analizadas, 29 % provinieron del servicio de urgencias. Las muestras aportadas por la unidad de cuidado intensivo reportaron más interferentes con ambos métodos; la estación automatizada reportó más interferentes que el método manual, con un índice kappa 0,52; la bilirrubina fue el interferente más detectado por ambos métodos. El método manual no evidenció el interferente volumen de llenado del tubo ni obstrucción fluídica-coágulo, los cuales fueron detectados por la estación automatizada.Conclusiones: la estación automatizada detectó más interferentes en comparación con el método manual. Los interferentes son errores preanalíticos en el laboratorio de hemostasia y son detectados con poca frecuencia de forma visual, especialmente los interferentes volúmenes de llenado del tubo y obstrucción fluídica-coágulo.
Cryptocurrency operations: topical issues of theory and practice of criminal law application
Authors: Dolgieva M. M.
Published: May 2019

The paper considers the opinions of domestic and foreign authors on the concept of cryptocurrency, the principles of its operation and the need to establish its legal status. The author’s definition of cryptocurrency is formulated and the thesis that cryptocurrency can be classified as «other property» is justified. The author analyzes the most common court decisions in criminal cases. Based on a study of foreign experience in the fight against illegal circulation of cryptocurrency, it was found that initially, before the emergence of mass demand for cryptocurrency all over the world, demand for them was observed in the criminal environment to pay for the supply of narcotic drugs and weapons, to finance terrorism and legalize (launder) income obtained in a criminal manner, in connection with which many people subsequently mistakenly assumed that transactions with cryptocurrencies are anonymous. Meanwhile, the cryptocurrency is far from being anonymous: each transaction carried out in a distributed network is permanently recorded in a public blockchain, which helps to solve crimes in this area. The adoption in the Russian Federation of a fundamental law containing the necessary terms and concepts regarding cryptocurrency activities and regulating the status of cryptocurrency in Russia will further develop measures for the criminal law protection of objects of encroachment that are currently not regulated in any way.
Recent Advances in Temperate Fruit Crop Improvement
Authors: Verma M. K. , Mir Javid Iqbal , Lal Shiv , Sahoo Tanushree
Published: May 2019

Globally India is the second largest producer of fruits; however the
productivity is significantly low as compared to advanced countries.
The majority of the temperate fruits and nuts are being cultivated
in the north-western Himalayan and small areas are lies in north
eastern parts. High altitude and temperate regions are capable to
produce good quality fruits. But the foothill where the chilling is
insufficient adversely affects the yield and quality. In India, majority
of the temperate fruits were introduced from other parts of the world
and some are indigenous to India like walnuts and wild apple species.
Therefore, the improvement of the temperate fruits and nuts were
taken place mainly through introduction of promising cultivars. The
exotic cultivars are still the backbone of fruit production in India particularly
for apple, pear, peach, plum and cherry. Promising varieties
were introduced from USA, UK, Germany, Italy, France, Australia, New
Zealand, Hungary and Bulgaria and were evaluated for commercial
exploitation. However, in walnutand almonds, production is mainly
from Indigenous cultivars/ local land races. These consisted of
non-descriptive trees and highly variable in yield and quality traits.
Recently, several varieties have been developed in India in apple,
peach, plum, apricot, cherry and walnut. The potential of these varieties
are immense for commercial exploitation. The paper attempt
to document the accomplishment made in temperate fruit and nut
improvement in perspective to Indian Scenario. The information is
valuable for breeders and academician for further studies.
Pharmacological Evaluation of Saccharum Officinarum Linn. as Anti-ulcer Agent
Authors: Dwivedi Preksha , Mishra Vikas , Agarwal Vipul , Jawaid Talha
Published: May 2019

The purpose of the study was to elucidate the antiulcer activity of
stem of Saccharum Officinarum (Poaceae) in albino rats against
aspirin induced gastric ulcer, ethanol induced gastric ulcer and
pylorus ligation induced gastric ulcer models. Groups of rats were
fasted overnight, received ranitidine (20 mg/kg) as a standard and
plant stem juice extract at dose of 0.75 mL/100 gm and 1.5 mL/100
gm as a treatment against aspirin induced gastric ulcer, ethanol
induced gastric ulcer and pylorus ligation induced gastric ulcer.
The treatment produced significant protection of ulcer induced by
aspirin, ethanol and pylorus ligation induced ulcer. The extract also
reduced ulcer index, volume of gastric content, free and total acidity,
suggesting that extract possesses significant anti-ulcer activity.
Study on the Comparative Performance Assessment of Distillation method by using a Conventional Method and
Elix Technology
Authors: Chaudhary Rubina , Barwa1 Anjali , Verma Rohan , Singh Shukti , Singh Rana Pratap
Published: May 2019

In this study, experiments were conducted on feed water and distill
water generated from simple solar still and from elix technology;
water quality analysis was done in laboratory to check the contaminants
removal efficiency from raw water samples. Changes in the
water quality may causes error in the compromised experimental
results, contaminated reagents and also may change the accuracy of
the equipment. The quality of water used in the laboratory is critical
for the success of the tests performed. Water quality parameter such
as pH, EC, TDS, COD, total alkalinity, total hardness, free residual
chlorine, sodium, turbidity, chloride, sulphate, floride, Total and
Fecal coliform and heavy metal like Pb, Zn, Cu, Fe, Mn, were analysed.
Distilled water is one of the essential components for chemical and
biological analysis in the field of analytical and medical testing. Many
distillation methods are available but they are either energy intensive
or use renewable (solar) energy like conventional solar still. In this
study, performance analysis was conducted for Non-conventional
(reverse osmosis and electro-de-ionization hybrid) and conventional
(solar still) distillation units. The values obtained were within the
standard range and it was concluded that the results of Elix water
testing from processing unit were found more promising for research
purpose.
ADIYAMAN SİYASAL DAVRANIŞ HARİTASI
Authors: DAĞ Rahman
Published: May 2019

Siyasal davranış, sadece oy kullanma ile sınırlandırılmayıp siyasi karar verme mekanizmalarını etkileyecek tüm davranış ve tutumları da kapsar hale gelmiştir. Özellikle sivil toplumun siyaseten etkili olması siyaseti etkime yollarını genişletmiştir. Aynı zamanda çeşitlenen siyasal davranışları etkileyen faktörler ayrı bir çalışma konusu haline gelmiştir. Bu çalışmada, siyasal sistem, medya, din, çevre, aile, etnisite ve ekonomi faktörlerinin Adıyaman seçmenlerinin siyasal davranışını ne derece etkilediğine bakılmaktadır. Yapılan anket çalışması ile elde edilen veriler doğrultusunda söz konusu faktörlerin frekans aralıkları üzerinden hangi faktörün daha fazla etkili olduğu ortaya çıkarılmıştır. Elde edilen sonuçlar ifadeci ve araçsal oy kavramları ışığında değerlendirmeye alınmıştır. Adıyaman ilinin tüm ilçe ve köylerinde anket uygulanmasına rağmen bu makale Adıyaman geneline odaklanmış ve sadece Adıyaman siyasal davranış haritası tablosu üzerine analiz yapılmıştır.
Actualidad de la gestión empresarial en las pymes
Authors: Pereira Bolaños Cliden Amanda
Published: May 2019

El artículo desarrolla una descripción de la situación actual de la gestión empresarial en las pymes del mundo con el propósito de analizar la problemática. La investigación realizada es descriptiva-exploratoria con un diseño documental, en la cual se revisan los artículos relacionados con el tema durante la última década. Los resultados muestran la problemática general de las pymes en la gestión de sus organizaciones. De igual manera, se analiza el contexto internacional por medio de datos que permiten demostrar las principales limitantes que se presentan y que afecta el entorno económico. Se toma como referente los casos de España, México y Colombia.
Literacy Engagement in Multilingual and Multicultural Learning Spaces
Authors: Kapoyannis Theodora
Published: May 2019

This article presents qualitative findings from a larger design-based research doctoral study in which I examined the impact of a curricular innovation to challenge the monolingual and monocultural norms of literacy practices and to be responsive to the linguistic and cultural landscape of 21st century classrooms. I collaborated with 11 university preservice teachers and 28 English language learners (ELLs) in Grades 2 and 3 to design and implement a literacy intervention, called the Name Jar Project, focused on cultivating literacy engagement. I used constant comparison analysis to analyze data sources, which included field notes, student artifacts, and preservice teachers’ reflections. This article documents the positive impact of the intervention in supporting the students’ linguistic and cultural needs, affirming their identities, and bolstering their vocabulary development.

Cet article présente les constatations qualitatives d’une étude de recherche de doctorat plus importante conforme au modèle méthodologique de recherche-design (design-based research, ou DBR) dans laquelle j’ai examiné l’impact d’une innovation pédagogique conçue pour remettre en cause les normes unilingues et uniculturelles des pratiques de littératie et pour permettre à l’enseignement de s’adapter au paysage linguistique et culturel des salles de classe du 21e siècle. J’ai collaboré avec 11 enseignantes et enseignants universitaires en formation et 28 apprenantes et apprenants de la langue anglaise (English language learners,ou ELLs) de 2e et 3e année afin de concevoir et de mettre en œuvre une intervention en matière de litératie, baptisée Name Jar Project, centrée sur une émarche favorable à la culture de la littératie. J’ai constamment eu recours à des techniques d’analyse comparative pour analyser les sources de données, lesquelles  comprenaient des notes, des artefacts associés au prénom de chaque élève et des réflexions d’enseignantes et enseignants en formation. Cet article documente l’impact positif de l’intervention sur la réponse aux besoins linguistiques et culturels des élèves, l’affirmation de leur identité et la stimulation du développement de leur vocabulaire.
A invisibilidade do Inativo: realidades jurídico-sociais da inatividade no Corpo de Bombeiros e Polícia Militar
Authors: De Araújo Marcos
Published: May 2019

Este trabalho, de métodos mistos concomitantes, objetiva examinar as atuais realidades jurídico-sociais nos diferentes postos e graduações após a inatividade, no Corpo de Bombeiros e na Polícia Militar do Distrito Federal, procurando identificar como esses militares se sentem no tocante ao tratamento a eles prestados por suas respectivas corporações. Busca também aquilatar se é jurídica e socialmente oportuna, e em que grau, a inserção de programa preparativo para a inatividade como Direito Fundamental. Para garantir a precisão dos resultados, evitando distorções de análise de interpretações, o artigo se baseia em coleta de informação de 452 questionários on-line. Visando entender a natureza do fenômeno estudado, adotou-se também entrevistas abertas e a observação participante.
Infeasibility and Structural Bias in Differential Evolution
Authors: Caraffini Fabio , Kononova Anna , Corne David
Published: May 2019

This paper investigates a range of popular differential evolution (DE) configurations to identify components responsible for emergence of structural bias – a recently identified tendency of algorithms to prefer some regions of search space over others, for reasons unrelated to objective function values. Previous work has explored this tendency for genetic algorithms (GA) and particle swarm optimisation (PSO), finding a relationship between population size and extent of structural bias, hence highlighting potential weaknesses of those algorithms. In current article, we focus on DE, extend the investigation to include consideration of an algorithmic component that is often overlooked – constraint handling mechanism. Towards this end, a wide range of DE configurations was tested here. Results suggest that DE is generally robust to structural bias. Unlike the case with GA and PSO, population size seems to have no influence on DE structural bias. Only one of variants studied – DE/current-to-best/1/bin – shows clear signs of bias, however, we show that this effect is mitigated by a judicious choice of constraint handling technique. These findings contribute towards explaining widespread success of DE variants in algorithm comparison studies; its robustness to structural bias represents the absence of a factor that may confound other algorithms.
The Evolution Process from Silver Nanoflakes to Nanomeshes to Effectively Address the Dilemma in the Conductivity and Stretchability Trade-offs in Elastic Electrodes
Authors: Chen Liqiao , Leng Zhe , Long Yunqian , Yu Xuan , Yu Xiaoming
Published: May 2019

Flexible and stretchable conductive materials have received significant attention in several applications such as flexible displays and sensors. In this paper, we report a highly dispersed porous Ag nanoflakes with clean surfaces were fabricated through an explosive growth process. The evolution process from silver nanoflakes to nanomeshes occurred by the novel “dissolution–recrystallization” solvothermal process. The as-obtained Ag meshes have the dual nature of nanoflakes and nanoparticles, which could create an intercross and interpenetration conductive network structures between silver and polymer in the printed elastic conductor, therefore, the silver meshes as conductive fillers used in elastic conductor simultaneously exhibit high conductivity and mechanical durability.
Distinct Subgroups of Amnestic Mild Cognitive Impairment as Identified by Soft Independent Modeling of Class Analogy
Authors: Tangwongchai Sookjaroen , Tawankanjanachot Itthipol , Tunvirachaisakul Chavit , Supasitthumrong Thitiporn , Hemrungrojn Solaphat , Chuchuen Phenphichcha , Snabboon Thiti , Carvalho André , Maes Michael
Published: May 2019

Amnestic mild cognitive impairment (aMCI) is a condition characterized by mild deficits in episodic and semantic memory and learning. The conversion rate of aMCI to Alzheimer disease (AD) is significantly higher in aMCI than in the general population. The aim of this study is to examine whether aMCI is a valid diagnostic category or whether aMCI comprises different subgroups based on cognitive functions. We recruited 60 aMCI patients, 60 with AD and 61 healthy controls who completed neuropsychological tests of the Consortium to Establish a Registry for Alzheimer’s Disease (CERAD-NP) and biomarkers including serum anion gap (AGAP). Principal component analysis, support vector machine and Soft Independent Modeling of Class Analogy (SIMCA) showed that AD patients and controls were highly significantly discrimanted from each other, while patients with aMCI overlap considerably with normal controls. SIMCA showed that 68.3% of the aMCI patients were assigned to the control class (named: aMCI-HC), 15% to AD (aMCI-AD), while 16.6% did not belong to either class (aMCI-strangers). aMCI-HC subjects showed sings of very mild cognitive decline and impaired recall. aMCI-strangers showed signs of mild cognitive impairment with impaired fluency and naming. aMCI-AD cases showed a cognitive profile reminiscent of AD an increased AGAP levels. In conclusion, our SIMCA model may classify subjects afforded a clinical diagnosis of aMCI according to Petersen’s criteria into three clinically relevant subgroups and help in the early detection of AD by identifying aMCI patients at risk to develop AD and those that have an AD prodrome.