bluuebunny/crossref_metadata_2025 huggingface dataset:
Aplicação de técnicas de sensoriamento remoto e geoprocessamento como apoio a estudos geológicos e geotécnicos para gestão ambiental do Município de Três Cachoeiras, litoral norte do RS, Brasil
Authors: Hoff Rosemary , Leite Juciara , Zouain Ricardo
Published: January 2022

As técnicas de sensoriamento remoto e geoprocessamento são fundamentais para a integração de dados de mapeamento geológico-geotécnico para o gerenciamento e planejamento regional. O Município de Três Cachoeiras, situado no Litoral Norte do Rio Grande do Sul faz parte da "Reserva da Biosfera da Mata Atlântica" e tem conflitos ambientais diversos, como áreas para disposição de resíduos sólidos, assentamento de loteamentos residenciais e industriais, jazidas de extração de material para construção, fontes de abasteci mento de água e áreas de preservação ambiental. O objetivo deste trabalho foi produzir mapas temáticos, empregando fotografias aéreas, imagens de satélite e modelo digital de elevação (MDE) e a integrar os dados num sistema de informações geográficas (SIG). Utilizaram-se fotografias aéreas, imagens de satélite ETM+ LANDSAT 7, além de informações altimétricas Shuttle RADAR Topographic Mission (SRTM). Foram inves tigados aspectos conflitantes pelo enfoque geológico-geotécnico, a partir de fotointerpretação, processamento de imagem e levantamento de campo, e os dados foram integrados por técnicas de geoprocessamento. A fotointerpretação gerou a rede de drenagem, litologia, morfo-estruturas e formações superficiais. O proces samento digital de imagem gerou mapas temáticos de rochas/solos e uso/cobertura do solo pelo método de classificação máxima verossimilhança (MAXVER) da imagem orbital. O modelo digital de elevação gerou a carta de declividade e a delimitação de reservas ecológicas baseada na legislação ambiental. O cruzamento destes temas permitiu a obtenção das cartas de formações superficiais, hidrogeológica e litológica. A integra ção destes temas gerou as cartas de recomendação: de extração de materiais para construção civil; de implan tação de obras de infra-estrutura; de disposição de resíduos sólidos e loteamentos; de agricultura; de implan tação de áreas destinadas à preservação ambiental e à recuperação.
Factor de qualidade em rochas ornamentais com base em ensaios mecânicos e envelhecimento artificial
Authors: Simão Joaquim , Carvalho Cristina , Silva Zenaide , Moura António
Published: January 2022

As rochas ornamentais em geral, incluindo as rochas graníticas, quando utilizadas em centros urbanos, entram processo de alteração acelerada, uma vez expostas a atmosferas poluídas. Para estudar estes efeitos realizaram-se ensaios de caracterização física e mecânica e ensaios de envelhecimento acelerado com soluções ácidas (HCl, H2SO4 e HNO3) conjugados com ensaios de gelividade nos granitos de Monção, Vila Real, Castelo de Vide e de Monforte, Gabro de Odivelas e Sienito Nefelínico de Monchique. Calculou-se a percentagem de decréscimo das propriedades das rochas relativamente ao valor inicial e um factor de quali dade Q. Os resultados obtidos forneceram indicações sobre as degradações sofridas pelas rochas, prevendo o seu comportamento quando utilizadas em circunstâncias semelhantes. O conhecimento sobre estas rochas no que diz respeito às limitações do ponto de vista tecnológico traduz-se numa garantia de qualidade para os pro dutos da indústria de rochas ornamentais.
Otimização da coagulação/floculação para tratamento de lixiviados
Authors: Paulino Patrícia , Rocha Etiene , Ferreira Joelma , Sobrinho Maurício
Published: January 2022

Os riscos ambientais apresentados pelo descarte de lixiviados estão relacionados às altas concen trações de poluentes orgânicos e nitrogênio amoniacal. O presente trabalho consiste na avaliação do processo de coagulação/floculação no tratamento de lixiviados gerados no Aterro da Muribeca-PE. Foi determinada a melhor dosagem da cal através de um planejamento fatorial 24. Para análise dos resultados do planejamento experimental fatorial, diagramas de Pareto com nível de significância de 95% foram empregados para ilustrar as estimativas dos efeitos principais lineares e de segunda ordem. A significância dos efeitos foi testada por análise de variância (ANOVA). Através do planejamento fatorial observou-se que a concentração de cal influenciou o processo tanto nos resultados da turbidez como para a remoção da cor e que estes resultados não estão associados apenas à concentração do agente coagulante, mas também a influência de outros fatores como a velocidade de floculação, tempo de floculação, massa do coagulante e tempo de sedimentação.
Geração de metano no Aterro Sanitário Metropolitano Centro, Salvador – Bahia
Authors: Santos Átila , Machado Sandro , Carvalho Miriam , Nascimento Júlio
Published: January 2022

Este artigo apresenta um estudo acerca da geração de metano (CH4) nas células do Aterro Sanitário Metropolitano Centro (ASMC), Salvador-BA. Parâmetros envolvidos no modelo de decaimento de primeira ordem, utilizados para simular o processo de perda de massa em ambiente anaeróbio e a geração de CH4 em aterros sanitários são mostrados. Resultados da caracterização de RSU obtidos em amostras coletadas no ASMC foram utilizados para previsão do potencial de geração de CH4, L0, em resíduos novos. Amostras de RSU com diferentes idades (1 a 10 anos) foram utilizadas para obtenção do potencial de geração de CH4 remanescente L0(t) e da constante relacionada à taxa de geração de CH4, k. Os parâmetros L0, L0(t) e k tam bém foram determinados por meio do ensaio do Potencial Bioquímico de Metano (BMP). Análises estatísticas para o L0 e para a previsão da geração de CH4 no ASMC foram realizadas, considerando um intervalo de con fiança de 70%. A comparação entre os valores de produção de biogás previstos e obtidos em campo se mos traram satisfatórios, apesar de discrepâncias observadas em função de mudanças no procedimento operacional de campo.
Investigação geofísica em aterro municipal de resíduos sólidos domiciliares, Cordeirópolis, Brasil
Authors: Moreira César , Braga Antonio , Martinelli Cesar
Published: January 2022

Este trabalho apresenta os resultados do método geofísico da Eletrorresistividade na avaliação de lixiviado percolado em solo, proveniente da decomposição de matéria orgânica contida em resíduos sólidos domiciliares. O sistema de operação do aterro consiste basicamente na escavação de valas com cinco metros de profundidade, deposição diária de 7m3 de resíduos sólidos domiciliares provenientes de um município de 17 000 habitantes e posterior cobertura pelo solo retirado durante a escavação das valas. A ausência de imper meabilização das valas ou de sistemas de coleta de gases e líquidos, justificam a aplicação da geofísica na caracterização e monitoramento do fluxo de percolados no solo e águas subterrâneas. A ocorrência de valores de resistividade inferiores a 30Ω.m nos resultados e ausência desta faixa de valores na linha de referência, aliado a característica de elevada quantidade de sólidos totais dissolvidos no líquido proveniente da decompo sição da matéria orgânica, revelam zonas de concentração de chorume no solo. Esta faixa de valores foi des crita em diversas investigações geofísicas realizadas em áreas de aterros de resíduos sólidos na região Sudeste do Brasil, notadamente caracterizadas por solos espessos e teores variáveis de argila e areia.
Estado actual de los sistemas e-learning
Authors: García-Peñalvo Francisco José
Published: January 2022

En este número especial de la revista Teoría de la Educación. Educación y Cultura en la Sociedad de la Información se abordan diferentes aspectos relacionados con los sistemas de formación electrónica, más conocidos como sistemas de e-formación o sistemas e-learning, desde distintos puntos de vista, que intentan reflejar el “mestizaje” científico que se presenta en este campo, y así dibujar un mapa actual del mismo, que incluya investigación y uso, con sus puntos fuertes y, especialmente, con sus áreas de mejora.
Instantiation of Java Generics
Authors: Soha Péter , Pataki Norbert
Published: January 2022

Type parametrization is an essential construct in modern programming languages. On one hand, Java offers generics, on the other hand, C++ offers templates for highly reusable code. The mechanism between these constructs differs and affects usage and runtime performance, as well. Java uses type erasure, C++ deals with instantiations.In this paper, we argue for an approach in Java which is similar to C++ template construct. We evaluate the runtime performance of instantiated code and we present our tool which is able to use Java generics as templates. This tool generates Java source code. We present how this approach improves the usage of Java generics.
Profile of Clinical Features and Visual Loss in Diabetic Retinopathy Associated with Anaemia in Patients of Chennai City, India
Authors: Manivannan Sowmiya Saras , Annamalai Radha , Muthukumar Muthayya
Published: January 2022

BACKGROUND Diabetic retinopathy is one of the commonest causes of preventable blindness. Anaemia develops earlier in diabetes patients and can hasten the development and progression of both microvascular and macrovascular complications of diabetes mellitus. The objective of the study was to identify and estimate the prevalence of anaemia in patients with diabetic retinopathy and its correlation with the progression of retinopathy, development of complications and the prognosis of vision. METHODS This was a retrospective study on 250 patients conducted over a period of 3 years. Comprehensive physical examination, ophthalmic evaluation using slit-lamp biomicroscopy, indirect ophthalmoscopy, fundus photography, ancillary fundus fluorescein angiography and optical coherence tomography (OCT) were performed. Blood investigations consisted of fasting blood sugar, glycosylated HbA1C, lipid profile and haemoglobin levels were estimated. RESULTS The prevalence of anaemia in patients with DM was 69 %. The prevalence of anaemia was higher in women and the age group most commonly affected was 45 to 55 years. Diabetic retinopathy was more common in men, but the severity of retinopathy was more in women. A significant association was seen between the duration of diabetes (longer than 5 years), the severity of anaemia, control of hypertension and hyperlipidaemia. The type of retinopathy most commonly associated with anaemia was moderate non-proliferative diabetic retinopathy with clinically significant macular oedema. Visual loss occurred in 16 patients. CONCLUSIONS Identification and treatment of anaemia can prevent the progression of retinopathy. Our study suggests that the evaluation and treatment of anaemia should be a part of initial and follow-up visits in all diabetic patients with ophthalmic features as there is a definite association between visual loss and anaemia in diabetes mellitus. KEY WORDS Anaemia, Diabetic Retinopathy, Maculopathy, Macular Oedema, Haemoglobin
Equivalent Cellular and Humoral Immunity to Varicella Zoster Virus in Patients With Inflammatory Bowel Disease and Healthy Older Adults for Whom Immunization Is Recommended
Authors: Caldera Freddy , Wald Arnold , Saha Sumona , Smith Ryan , McCrone Sue , Farraye Francis A. , Hayney Mary S.
Published: January 2022

INTRODUCTION:

Patients with inflammatory bowel disease (IBD) are at an increased risk of herpes zoster (HZ). HZ is caused by reactivation of the varicella zoster virus (VZV) and is prevented by strong VZV-specific cell-mediated immunity. The aim of our study was to evaluate whether patients with IBD had lower or equivalent protection compared with healthy controls (HCs) at age 50 years and older.

METHODS:

We performed a cross-sectional study at a single academic center and evaluated cellular and humoral immunity to VZV in patients with IBD at age 35–49 years vs HCs aged 50–59 years. All patients with IBD were on stable medication regimens for at least 3 months. VZV-specific cell-mediated immunity was measured via ELISPOT, and humoral immunity was measured via a quantitative VZV antibody enzyme-linked immunosorbent assay assay.

RESULTS:

Seventy-seven patients with IBD and 12 HCs were enrolled in the study. There was no significant difference in ELISPOT counts between patients with IBD and HCs (P = 0.54). In addition, there was also no significant difference between ELISPOT counts in immunosuppressed patients with IBD (N = 45) and HCs (P = 0.32). We also found no correlations between ELISPOT counts and age (Spearman rho 0.014; P = 0.90). Patients with IBD had similar IgG VZV antibody levels (median 19 mIU/mL; range 0.5–218) compared with HCs (median 23.5 mIU/mL (range 4–34); P = 0.54).

DISCUSSION:

Young patients with IBD have equivalent cellular and humoral immunity to VZV as healthy older adults in whom HZ immunization is recommended.
Variation of positive predictive values of fecal immunochemical tests by polygenic risk score in a large screening cohort
Authors: Niedermaier Tobias , Balavarca Yesilda , Gies Anton , Weigl Korbinian , Guo Feng , Alwers Elizabeth , Hoffmeister Michael , Brenner Hermann
Published: January 2022

Introduction:

Prevalence of colorectal neoplasms varies by polygenic risk scores (PRS). We aimed to assess to what extent PRS might be relevant for defining personalized cutoff values for fecal immunochemical tests (FITs) in colorectal cancer (CRC) screening.

Methods:

Among 5,306 participants of screening colonoscopy who provided a stool sample for a quantitative FIT (Ridascreen Hemoglobin or FOB Gold) prior to colonoscopy a PRS was determined, based on the number of risk alleles in 140 , single nucleotide polymorphism. Subjects were classified into low, medium and high genetic risk for colorectal neoplasms according to PRS tertiles. We calculated positive predictive values (PPVs) and numbers needed to scope (NNS) to detect one advanced neoplasm (AN) by risk group, and cutoff variation needed to achieve comparable PPVs across risk groups in the samples tested with Ridascreen (N=1,271) and FOB Gold (N=4,035) independently, using cutoffs yielding 85%, 90% or 95% specificity.

Results:

Performance of both FITs was very similar within each PRS group. For a given cutoff, PPVs were consistently higher by 11%-15% units in the high-risk PRS group compared to the low-risk group (all P-values <0.05). Correspondingly, numbers needed to scope (NNS) to detect one advanced neoplasm varied from 2 (high PRS, high cutoff) to 5 (low PRS, low cutoff). Conversely, very different FIT cutoffs would be needed to ensure comparable PPVs across PRS groups.

Discussion:

PPVs and NNS of FITs varied widely across people with high and low genetic risk score. Further research should evaluate the relevance of these differences for personalized CRC screening.

Funding Source:

This study was partly funded by grants from the German Research Council (DFG, grant No. BR1704/16-1), the Federal Ministry of Education and Research (BMBF, grant no. 01GL1712), and the German Cancer Aid (No. 70113330).
THE BÍLINA TUNNEL – SELECTED GEOTECHNICAL ASPECTS OF A PROPOSED UNDERGROUND STRUCTURE
Authors: Sotorník Viktor , Černoch Petr , Košťál Jiří
Published: January 2022

Every workday the city of Bílina, with the I/13 road running through it, suffers from traffic congestion. The road is designed as dual carriageway outside Bílina but only as a single carriageway inside the city. Three roundabouts further complicate the situation. As a solution a 1,3 km long tunnel going under the city was proposed. The preliminary geotechnical investigation describes the geological conditions of the area, suggests the most appropriate localisation details of the tunnel, points out several complications that can be expected and finally offers solutions to mitigate them.
Late-Onset Behavioral and Synaptic Consequences of L-Type Ca2+Channel Activation in the Basolateral Amygdala of Developing Rats
Authors: Zhang Yiming , Sack Anne-Sophie , Jones Karen L. , Yang Yi , Garcia Esperanza , Snutch Terrance P.
Published: January 2022

Postnatal CNS development is fine-tuned to drive the functional needs of succeeding life stages; accordingly, the emergence of sensory and motor functions, behavioral patterns and cognitive abilities relies on a complex interplay of signaling pathways. Strictly regulated Ca2+signaling mediated by L-type channels (LTCCs) is crucial in neural circuit development and aberrant increases in neuronal LTCC activity are linked to neurodevelopmental and psychiatric disorders. In the amygdala, a brain region that integrates signals associated with aversive and rewarding stimuli, LTCCs contribute to NMDA-independent long-term potentiation (LTP) and are required for the consolidation and extinction of fear memory.In vitrostudies have elucidated distinct electrophysiological and synaptic properties characterizing the transition from immature to functionally mature basolateral subdivision of the amygdala (BLA) principal neurons. Further, acute increase of LTCC activity selectively regulates excitability and spontaneous synaptic activity in immature BLA neurons, suggesting an age-dependent regulation of BLA circuitry by LTCCs. This study aimed to elucidate whether early life alterations in LTCC activity subsequently affect synaptic strength and amygdala-dependent behaviors in early adulthood.In vivointra-amygdala injection of an LTCC agonist at a critical period of postnatal neurodevelopment in male rat pups was used to examine synaptic plasticity of BLA excitatory inputs, expression of immediate early genes (IEGs) and glutamate receptors, as well as anxiety and social affiliation behaviors at a juvenile age. Results indicate that enhanced LTCC activity in immature BLA principal neurons trigger persistent changes in the developmental trajectory to modify membrane properties and synaptic LTP at later stages, concomitant with alterations in amygdala-related behavioral patterns.
Somatosensory Evoked Potentials Reveal Reduced Embodiment of Emotions in Autism
Authors: Fanghella Martina , Gaigg Sebastian B , Candidi Matteo , Forster Bettina , Calvo-Merino Beatriz
Published: January 2022

Consistent with current models of embodied emotions, this study investigates whether the somatosensory system shows reduced sensitivity to facial emotional expressions in autistic compared with neurotypical individuals, and whether these differences are independent from between-group differences in visual processing of facial stimuli. To investigate the dynamics of somatosensory activity over and above visual carryover effects, we recorded EEG activity from two groups of autism spectrum disorder (ASD) or typically developing (TD) humans (male and female), while they were performing a facial emotion discrimination task and a control gender task. To probe the state of the somatosensory system during face processing, in 50% of trials we evoked somatosensory activity by delivering task-irrelevant tactile taps on participants' index finger, 105 ms after visual stimulus onset. Importantly, we isolated somatosensory from concurrent visual activity by subtracting visual responses from activity evoked by somatosensory and visual stimuli. Results revealed significant task-dependent group differences in mid-latency components of somatosensory evoked potentials (SEPs). ASD participants showed a selective reduction of SEP amplitudes (P100) compared with TD during emotion task; and TD, but not ASD, showed increased somatosensory responses during emotion compared with gender discrimination. Interestingly, autistic traits, but not alexithymia, significantly predicted SEP amplitudes evoked during emotion, but not gender, task. Importantly, we did not observe the same pattern of group differences in visual responses. Our study provides direct evidence of reduced recruitment of the somatosensory system during emotion discrimination in ASD and suggests that this effect is not a byproduct of differences in visual processing.

SIGNIFICANCE STATEMENTThe somatosensory system is involved in embodiment of visually presented facial expressions of emotion. Despite autism being characterized by difficulties in emotion-related processing, no studies have addressed whether this extends to embodied representations of others' emotions. By dissociating somatosensory activity from visual evoked potentials, we provide the first evidence of reduced recruitment of the somatosensory system during emotion discrimination in autistic participants, independently from differences in visual processing between typically developing and autism spectrum disorder participants. Our study uses a novel methodology to reveal the neural dynamics underlying difficulties in emotion recognition in autism spectrum disorder and provides direct evidence that embodied simulation of others' emotional expressions operates differently in autistic individuals.
Single Calcium Channel Nanodomains Drive Presynaptic Calcium Entry at Lamprey Reticulospinal Presynaptic Terminals
Authors: Ramachandran Shankar , Rodgriguez Shelagh , Potcoava Mariana , Alford Simon
Published: January 2022

Efficient and reliable neurotransmission requires precise coupling between action potentials (APs), Ca2+entry and neurotransmitter release. However, Ca2+requirements for release, including the number of channels required, their subtypes, and their location with respect to primed vesicles, remains to be precisely defined for central synapses. Indeed, Ca2+entry may occur through small numbers or even single open Ca2+channels, but these questions remain largely unexplored in simple active zone (AZ) synapses common in the nervous system, and key to addressing Ca2+channel and synaptic dysfunction underlying numerous neurologic and neuropsychiatric disorders. Here, we present single channel analysis of evoked AZ Ca2+entry, using cell-attached patch clamp and lattice light-sheet microscopy (LLSM), resolving small channel numbers evoking Ca2+entry following depolarization, at single AZs in individual central lamprey reticulospinal presynaptic terminals from male and females. We show a small pool (mean of 23) of Ca2+channels at each terminal, comprising N-(CaV2.2), P/Q-(CaV2.1), and R-(CaV2.3) subtypes, available to gate neurotransmitter release. Significantly, of this pool only one to seven channels (mean of 4) open on depolarization. High temporal fidelity lattice light-sheet imaging reveals AP-evoked Ca2+transients exhibiting quantal amplitude variations of 0–6 event sizes between individual APs and stochastic variation of precise locations of Ca2+entry within the AZ. Further, total Ca2+channel numbers at each AZ correlate to the number of presynaptic primed synaptic vesicles. Dispersion of channel openings across the AZ and the similar number of primed vesicles and channels indicate that Ca2+entry via as few as one channel may trigger neurotransmitter release.

SIGNIFICANCE STATEMENTPresynaptic Ca2+entry through voltage-gated calcium channels (VGCCs) causes neurotransmitter release. To understand neurotransmission, its modulation, and plasticity, we must quantify Ca2+entry and its relationship to vesicle fusion. This requires direct recordings from active zones (AZs), previously possible only at calyceal terminals containing many AZs, where few channels open following action potentials (APs; Sheng et al., 2012), and even single channel openings may trigger release (Stanley, 1991, 1993). However, recording from more conventional terminals with single AZs commonly found centrally has thus far been impossible. We addressed this by cell-attached recordings from acutely dissociated single lamprey giant axon AZs, and by lattice light sheet microscopy of presynaptic Ca2+entry. We demonstrate nanodomains of presynaptic VGCCs coupling with primed vesicles with 1:1 stoichiometry.
The Role Of Osteopontin In Patients With Type 2 Diabetes And Cognitive Impairment
Authors: Matveeva Maria V. , Samoylova Yulia G. , Oleynik Oksana A. , Ratkina Ksenia R. , Tonkikh Olga S. , Podchinenova Daria V. , Kudlay Dmitry A.
Published: January 2022

Background — type 2 diabetes is associated with obesity and cardiovascular disease; in combination with dysmetabolic and proinflammatory pathophysiological mechanisms, it leads to cognitive impairment. Objective — analysis of the osteopontin role in formation of cognitive disorders in patients with type 2 diabetes. Material and Methods — the study complies with generally accepted ethical rules; it was approved by the Ethics Committee of Siberian State Medical University. It involved 50 patients with type 2 diabetes, who were divided into groups depending on the presence of cognitive impairment; the control group consisted of 25 subjects. All patients underwent general clinical examination, blood sampling for biochemical parameters, and plasma osteopontin content assessment. Magnetic resonance imaging (MRI) was performed on SIGNA Creator E magnetic resonance imaging system, GE Healthcare, 1.5 T, China. The employed techniques included dynamic contrast and arterial spin labeling, proton spectroscopy, tractography. SPSS Statistics software was used for statistical analysis. Results — osteopontin levels were higher in patients with excess weight, hyperglycemia, hyperuricemia, dyslipidemia, and cognitive impairment; and in neuroimaging studies with microangiopathy, based on perfusion MRI, with impaired white matter integration, as well as with neurometabolism of choline, creatine and phosphocreatine metabolites in the hippocampus, as well as their NAA/Cr, NAA/Cho, Cho/Cr ratios (p≤0.05). Conclusion — patients with type 2 diabetes, along with cognitive and metabolic disorders, exhibited elevated levels of osteopontin, which was also associated with impaired cerebral vascularization in general, and white matter organization, as well as neurometabolism in the hippocampus.
Ultrasound diagnosis of congestion in the pulmonary and systemic circulations in patients with atrial fibrillation and chronic heart failure
Authors: Kirillova Venera V. , Smorgon Andrey V. , Garganeeva Alla A. , Batalov Roman E. , Meshchaninov Viktor N. , Sokolova Lyudmila A. , Blagodareva Maria S. , Khlynin Mikhail S. , Popov Sergey V.
Published: January 2022

Rationale — Fluid retention is among the most common causes of heart failure decompensation. The goal of our study was to evaluate the sensitivity and specificity of the ultrasound method for evaluating congestive phenomena in both systemic and pulmonary circulatory systems in patients with atrial fibrillation (AF) and chronic heart failure (CHF). Material and Methods — The study included 28 patients with paroxysmal AF, with or without CHF, who were scheduled for radiofrequency pulmonary vein isolation. The maximum and minimum diameters of the right superior pulmonary vein (RSPV) and inferior vena cava (IVC) were measured via echocardiography on expiration. Mean blood pressure in both right and left atria was measured intraoperatively. We calculated the correlations between maximum and minimum diameters of the RSPV and a mean pressure in the left atrium, as well as between IVC on expiration and a mean pressure in the right atrium, and evaluated the sensitivity and specificity of ultrasound diagnostics for evaluating congestive phenomena in both systemic and pulmonary circulation. Results — We established positive correlation between the minimum diameter of RSPV and invasively measured mean left atrial pressure (R=0.65, P<0.05), and between invasively measured mean right atrial pressure and IVC diameter on expiration (R=0.49, P<0.05). The proposed method sensitivity for detecting pulmonary venous hypertension (PVH) on the basis of the maximum RSPV diameter ≥21.7 mm was 75%, and the specificity was 86%. The sensitivity and specificity for detecting PVH on the basis of the minimum RSPV diameter ≥10.5 mm constituted 85% and 86%, respectively. When using the IVC diameter on expiration ≥18.5 mm as an indicator, the sensitivity and specificity for detecting PVH were evaluated at the levels of 100% and 92%, correspondingly. Conclusion — The proposed ultrasound method of diagnosing congestion in pulmonary circulation via maximum and/or minimum diameter of the RSPV can be effectively employed in clinical practice in the same way as conventional technique of congestion diagnostics in systemic circulation via the diameter of IVC in patients with atrial fibrillation and chronic heart failure.
Modern Approaches To Cardiovascular Amyloidosis Treatment
Authors: Morozkina Svetlana N. , Snetkov Petr P. , Olekhnovich Roman O. , Uspenskaya Mayya V.
Published: January 2022

Cardiovascular (cardiac) amyloidosis (CA) is a clinical pathology, usually of a geneticallymediated nature, initiated by the precipitation process of the insoluble fibrous protein with β-pleated sheet secondary structure. Such anomalous changes lead to the formation of amyloid fibrils, which may give rise to various forms of amyloidosis. Amyloid formation can be found in various organs and systems, such as cardiovascular system, central and peripheral nervous systems, liver, urinary tract, etc. CA is a rare degenerative disease resulting in congestive cardiac failure and heart arrhythmia with subsequent untimely death. Unfortunately, up to date, the choice of medications for treating amyloidosis is very limited. In this paper, we review clinically used pharmaceutical drugs for CA treatment, along with some delivery systems for such compounds.
Primary Open-Angle Glaucoma Combined With Concomitant Somatic Pathology
Authors: Zagidullina Aigul Sh. , Aznabaev Bulat M.
Published: January 2022

The goal of the study was to assess the role of concomitant somatic pathology and calculate the total comorbidity index of primary open-angle glaucoma (POAG) in different age groups. Material and Methods — The study included 624 patients (1199 eyes) with POAG aged 45 to 93 years. The control group included 161 people without glaucoma. Patients underwent a comprehensive ophthalmological examination. The Charlson comorbidity index (CI) was calculated, taking into account the concomitant somatic diseases and the age of the patients. Statistical processing of the obtained material was carried out using the IBM SPSS Statistics v.21 program with standard methods of descriptive statistics. Results — with an increase in the age of POAG patients, significant growth in the number of patients with hypertension, coronary heart disease, cerebrovascular accident, atherosclerosis, degenerative diseases of the nervous system, diabetes mellitus, respiratory diseases, musculoskeletal system, and other pathologies were observed. CI was increased in POAG patients with age: 3.02 times for the old age patients, 4.2 times for very old age subjects, compared with middle-aged patients (p<0.001), as well as 1.42 and 1.97 times, respectively, compared with the control group (p<0.001). Conclusion —In patients with POAG, the number of patients with hypertension, ischemic heart disease, cerebrovascular disorders, atherosclerosis, degenerative diseases of the nervous system, diabetes mellitus, respiratory diseases, musculoskeletal system disorders, and other pathologies increased significantly with age. The comorbidity index in POAG patients exhibited growth with age: 3.02 times in the old age group and 4.2 times in the group of very old age people vs. the group of middle-aged patients (p<0.001); and 1.42 and 1.97 times, respectively, vs. the control group (p<0.001).
Analysis of Survey Responses to the Window Views
Authors: Koprivec Ljudmila , Zbašnik-Senegačnik Martina , Kristl Živa
Published: January 2022

Glazing elements are main architectural elements that allow visible contact with the exterior. The importance of looking out the window is neglected in practice, although many studies find that it has a beneficial effect on the well-being and health of observers and increases their living and visual comfort. The purpose of this study is to determine whether there are common denominators in the selected window views, which trigger comparable responses in observers. The study used a wide range of motifs of the window view. Quantitative and qualitative shares of various elements in the motif such as greenery, distance, complexity, and narrative elements are discussed and their impact on the response of observers. Responses are obtained through survey. The analysis is performed with the SPSS tool and with the qualitative evaluation of individual elements. The study confirmed that the motive of the window view influences the subjective responses of the respondents. The comparison of responses showed a consistent response of observers to a specific element in the motive of the window view. A predominantly unambiguous response was found in the motifs, which contained narrative element and an element of fascination. Indirectly, it can be concluded that the views of the natural environment are more desirable, while the views of predominantly urban environments are less attractive.
PENGARUH MOTIVASI DAN LINGKUNGAN KELUARGA MELALUI SELF EFFICACY TERHADAP MINAT MENJADI GURU
Authors: Sari Renita , Rusdarti Rusdarti
Published: January 2022

This study aims to investigate the effect of self-motivation and family environment on the interest in becoming teachers directly or indirectly through self-efficacy as a mediator variable. The research method employed was quantitative method with path analysis and Sobel test. The subjects of this study were all students of Economics Education Faculty of Economics, Universitas Negeri Semarang year 2014 with a population of 399 and a sample of 100 respondents. The method used was of data collection used questionnaires. The results show that (1) self-motivation positively affects self-efficacy by 21.9%. (2) Family environment negatively affects self-efficacy by 32.03%. (3) The total effect of self-motivation on the interest in becoming teachers through self-efficacy is 41.2%. (4) The total effect of family environment on the interest in becoming teachers through self-efficacy is-20.38%. (5) Self-efficacy positively affects the interest in becoming teachers by 16.16%. The suggestions of this study are students of economics education should know more about their interests in becoming teachers and should seek adequate knowledge and information about teacher profession. In addition, family should not give excessive attention and treatment to children because it can reduce the childrenâ€™s abilities.
PENGARUH PRAKTIK KERJA INDUSTRI, PRESTASI BELAJAR DAN MOTIVASI MEMASUKI DUNIA KERJA TERHADAP KESIAPAN KERJA SISWA KELAS XI SMK
Authors: Wibowo Rizal Eko , Santoso Jarot Tri Bowo , Widiyanto Widiyanto
Published: January 2022

Tujuan penelitian ini adalah untuk menguji pengaruh prakerin, prestasi belajar di sekolah, dan motivasi memasuki kerja terhadap kesiapan kerja. Populasi dalam penelitian ini adalah siswa kelas XI SMK Palebon Semarang. Jumlah populasi dari penelitian sebanyak 283 siswa dan sampel 166 siswa yang dihitung berdasarkan rumus Slovin dengan taraf kesalahan 5%. Metode pengumpulan data menggunakan observasi, dokumentasi dan kuesioner. Metode analisis data menggunakan analisis regresi berganda, analisis uji hipotesis, dan analisis deskriptif persentase dengan menggunakan bantuan program SPSS for Windows Release 20. Hasil penelitian menunjukkan bahwa analisis regresi berganda diperoleh persamaan  Y = 30,773 + 0435X1 + 0,414X2 + 0,2147X3 + e. Secara simultan prakerin, prestasi belajar di sekolah, dan motivasi memasuki dunia kerja berpengaruh positif dan signifikan terhadap kesiapan kerja sebesar 50,9%. Sedangkan secara parsial untuk prakerin (praktik kerja industri) berpengaruh positif dan signifikan terhadap kesiapan kerja sebesar 40,83%, prestasi belajar di sekolah berpengaruh positif dan siginifikan terhadap kesiapan kerja sebesar 2,75%, dan motivasi memasuki dunia kerja  berpengaruh berpengaruh positif dan siginifikan terhadap kesiapan kerja sebesar 2,72%.
Pengaruh Kredit Usaha Rakyat (KUR), Total Aset, Jumlah Tenaga Kerja, Biaya Pemasaran Dan Lokasi Usaha Terhadap Pendapatan Usaha Mikro Kecil dan Menengah (UMKM) Berbasis Ekonomi Kreatif di Kota Semarang
Authors: Meilinda Devi , Mahmud Amir
Published: January 2022

Micro Small and Medium Enterprises (MSMEs) is one solution of theeconomic system that is not alike at all global impact that hit the world including one of them is creative economy-based MSMEs in Semarang City. The purpose of this study is to determine whether there is influence of people's business credit, total assets, the amount of labor, marketing costs and location of business to revenue-based MSMEs creative economy in the city of Semarang.The population in this study is all MSMEs in Semarang City as much as 7015. The sample of this study was taken above the suggestion of sampling from Roscue that is minimalubs 60 respondents. Data method using questionnaire. The method used is descriptive statistics and multiple linear regression.The results showed that: (1) the variable of People's Business Credit (KUR), total assets, total labor and marketing costs partially affect MSME income, (2) business location partially has no effect on MSME income, (3) simultaneously People's Business Credit (KUR), total assets, number of workers, marketing costs and business location affect the income of MSMEs.
Pengaruh Praktik Kerja Industri, Informasi Dunia Kerja Dan Motivasi Memasuki Dunia Kerja Terhadap Kesiapan Kerja Siswa
Authors: Susilo Sri Muji , Ismiyati Ismiyati
Published: January 2022

The purpose of this study was to determine the effect of industrial work practices, information on the world of work and motivation to enter the world of work on student work readiness at SMK Bhakti Persada Kendal. The population in this study were all students of class XII Office Administration expertise program. The research sample consisted of 59 respondents who were taken from all students of class XII of the Office Administration expertise program of SMK Bhakti Persada Kendal. Data were collected by means of a questionnaire and analyzed by using multiple linear regression. The results of this study are (1) there is a partially positive effect of industrial work practices on job readiness of 18.49%, (2) there is a partial positive effect of information on the world of work on work readiness by 17.30%, (3) there is an effect Partially positive motivation to enter the world of work on work readiness is 14.66%, (4) there is a positive and significant effect simultaneously between the variables of industrial work practices, information on the world of work, and entering the world of work on student work readiness by 76.4%.
Pengaruh Kualitas Lingkungan Keluarga, Association of Peers Group, Hidden Curriculum, dan Internet Social Media Exposure Terhadap Karakter Siswa (Studi pada SMK Negeri 2 Temanggung)
Authors: Azizah Aullya Nurul , Bowo Santoso Jarot Tri
Published: January 2022

The purpose of this research is to test the influence of family environment quality, association of peers group, hidden curriculum, and internet social media exposure to students’ character simultaneously or partially. The population of this study is all ten and twelve grade accounting students of Vocational High School 2 in Temanggung in the Academic Year of 2017/2018 in the number of 150 students. The sample used is 110 students that is taken using Slovin formula with proportionate random sampling technique. This study uses a quantitative approach with data collection methods using questionnaires. The method for analysing data used is descriptive statistic analysis and multiple regression analysis. The results of study indicated that family environment quality, association of peers group, hidden curriculum, and internet social media exposure simultaneously influenced on the students’ character 60.2%. While the partial variable family environment quality has a positive and significant effect by 27% to the students’ character, association of peers group has positive and significant effect by 26% to the students’ character, hidden curriculum has a positive and significant effect by 7% to the students’ character, while internet social media exposure has positive and significant affect by 4% to the students’ character.
Pengaruh Personality Motivation, Self-Efficacy, dan Career Adaptability Terhadap Komitmen Karir
Authors: Nuraini Umi , Susilowati Nurdian , Khoirunnisa Khoirunnisa , Ananda Delya Saski , Febriyanti Ika Dian Anggraini
Published: January 2022

Tujuan penelitian ini adalah untuk mengetahui pengaruh minat intrinsik seperti personality motivation, self-efficacy dan career adaptability terhadap komitmen karir. Populasi dalam penelitian ini adalah mahasiswa Pendidikan Akuntansi Universitas Negeri Semarang Tahun Angkatan 2018. Desain penelitian dalam penelitian ini adalah kuantitatif. Jumlah populasi Mahasiswa Pendidikan Akuntansi adalah 119 mahasiswa. Sampel yang digunakan yaitu proportional random sampling. Diperoleh sebanyak 80 sampel. Teknik pengumpulan data menggunakan kuesioner google form secara online. Teknik analisis data yang digunakan adalah analisis regresi berganda dengan bantuan alat IBM SPSS 22. Hasil penelitian ini menunjukkan personality motivation, self-efficacy dan career adaptability secara simultan memiliki pengaruh terhadap dalam kategori cukup. Berdasarkan hasil uji hipotesis penelitian ini, dari keempat hipotesis yang diajukan terdapat tiga hipotesis diterima dan satu hipotesis ditolak. Personality motivation dan career adaptability masing-masing memiliki pengaruh signifikan terhadap komitmen karir profesi guru akuntansi pada mahasiswa pendidikan akuntansi. Sedangkan, self-efficacy tidak memiliki pengaruh signifikan terhadap komitmen karir profesi guru akuntansi pada mahasiswa pendidikan akuntansi. Penelitian ini memiliki jangkauan wilayah penelitian yang kecil. Sehingga, Penelitian belum dapat secara maksimal mengukur komitmen karir Pendidikan di Universitas Negeri Semarang untuk setiap tahun angkatan yang ada.
Pengaruh Bahan Baku, Tenaga Kerja dan Kemampuan Manajerial Terhadap Jumlah Produksi Tahu
Authors: Azizah Nur , Setiaji Khasan
Published: January 2022

One most influential things about the total production is the factors of production.This research aims  to determine the effect of raw materials, labor, and managerial ability on the total production of tofu in Adiwerna Village, Adiwerna district, Tegal. The population in this study were tofu craftsmen in Adiwerna Village, Adiwerna district, Tegal Regency in the amount of 319 craftsmen and obtained sample of 76 people using simple random sampling. Data collection tool was the questionnaire or questionnaire method. analysis. The result of the research shows that there is influence between raw materials, labor, and managerial ability to total production either simultaneously or partially. The simultaneous effect of 0,518 or 59,1% whereas 40,9% is explained by other factors. Partially raw material , labor, and managerial ability to the total production are 14,67%, 16,31%, and 7,73%. The conclusion of this research is there is positive and significant influence between raw materials, labor, and managerial ability to total production. The suggestions of this study are Tofu craftsmen must pay attention to the availability of raw materials when the prices increase, they can augment labor productivity well and improve their capabilities so that the level of production can be maintained both in quantity and quality.
Analysis of the Role of Android-Based Learning Media in Learning Critical Thinking Skills and Scientific Attitude
Authors: Isnaeni W. , Sujatmiko Y. A. , Pujiasih P.
Published: January 2022

This study aims to analyze and describe android-based learning media's role in teaching students critical thinking skills and scientific attitudes. The learning media are Androwebic (android-based webcomic) and E-Bokartumban (e-book on plant diversity in Banjarnegara), developed previously. This research is a qualitative descriptive study involving 301 students, six biology teachers and six high school students. The data collected includes critical thinking skills, analytical skills, scientific attitudes, environmental care attitudes, media components supporting student competence, and teacher and student responses. Data on critical thinking and analytical skills were measured using tests and non-tests. Other data were measured using non-test instruments, including interview guides, scientific attitude observation sheets, students' environmental care attitudes, media component observation sheets, and student and teacher questionnaires. Quantitative data on critical thinking and analytical skills were analyzed using the n-gain test, while other data were descriptively analyzed. The research results showed that the E-Bokartumban and Androwebic components support students' critical thinking skills, analytical skills, and environmental care attitudes. Androwebic can train students' analytical thinking skills and scientific attitude. The two media developed were considered very helpful in the learning process. The study concluded that Android-based media in Androwebic and E-Bokartumban have a vital role in training critical thinking skills, analytical skills, scientific attitudes, and environmental care attitudes.
Reflective Practices in Inquiry Learning: Its Effectiveness in Training Pre-Service Teachers' Critical Thinking Viewed from Cognitive Styles
Authors: Verawati N. N. S. P. , Hikmawati H. , Prayogi S. , Bilad M. R.
Published: January 2022

This study aims to evaluate the effectiveness of reflective practices in inquiry learning to train pre-service teachers' critical thinking skills viewed from cognitive styles. The quasi-experimental design was conducted with two sample groups given the same treatment at the pretest, reflective-inquiry practice learning, and posttest. Before the pretest, each sample was given GEFT (Group Embedded Figures Test) to determine the sample of the FI (field-independent) or FD (field dependent) cognitive style. Two sample groups were pre-service physics teachers (PPT) at two different universities in Mataram, Indonesia. The measurement of critical thinking employed essay tests. Critical thinking skills data were analyzed descriptively (mean difference scores of pretest-posttest and N-gain analysis) and statistically (independent sample t-test) employing SPSS software. The effectiveness of reflective inquiry learning is measured by increasing critical thinking scores where the minimum posttest has the "critical" criteria. The study results indicated that the tendency of cognitive style FI was more dominant than FD. The critical thinking measurement showed that each FD/FI group was categorized as "critical," and the increase of critical thinking scores in the two groups was categorized as a "moderate" category. In line with this, statistical analysis (hypothesis testing at a significance level of 0.05) showed no difference in the increase of critical thinking scores between PPT belonging to FD and FI. This study showed that the reflective practice in inquiry learning effectively improved the pre-service teachers' critical thinking skills with the FD and FI cognitive styles. Reflective practices are a new way of inquiry learning to train critical thinking and can be used as a reference for its structured implementation in regular lectures.