bluuebunny/crossref_metadata_2025 huggingface dataset:
Emergency removal of traumatic foreign particles from submandibular region – A case report
Authors: Khan Zibran , Tondon Arun , Jadaun Gargi , Nevkar Soham , Takhellambam Priyanka
Published: October 2024

Angle grinders are undeniably one of the most perilous tools utilized in industry and agriculture, with over 5000 injuries documented, and they can even be fatal if major blood vessels in the neck are ruptured and neurological damage occurs. Angle grinders can cause severe injuries to the head, neck, and face because their high-speed discs do not respect the body's natural boundaries or structures. These injuries can be disfiguring, permanently disabling, or even fatal. To attain aesthetically pleasing outcomes, it is imperative to thoroughly cleanse the wound, excise any damaged tissue, and meticulously close the wound in layers. The article presents a case of a penetrating injury caused by using an angle grinder and discusses effective management and prevention of such injuries.
Outcomes of laparoscopic sacrocolpopexy using self-cut mesh on pelvic organ prolapse
Authors: Meutia Alfa Putri , Djusad Suskhan , Priyatini Tyas , Yonathan Kevin , Hayashi Tokumasa , Nomura Jimmy
Published: October 2024

Objectives:

The objective of the study was to investigate the long-term outcome and complication rate of laparoscopic sacrocolpopexy (LSC) using self-cut mesh as pelvic organ prolapse treatment.

Methods:

A retrospective cohort study on patients undergoing LSC was done at Kameda Medical Center from January 2013 to January 2018. Data for this study were taken from all women with pelvic organ prolapse who had undergone LSC using self-cut polypropylene mesh. Patients with a previous history of hysterectomy were excluded from the study. An evaluation was done preoperatively, on 6-month and 1-year postoperative follow-up period using Pelvic Organ Prolapse Quantification (POP-Q) and The International Consultation on Incontinence Questionnaire-short form (ICIQ-SF) questionnaire.

Results:

There were 702 subjects who met the inclusion and exclusion criteria. The clinical characteristics of the subjects were recorded. The scores during admission, 6 months and 1 year postoperative are: POP Q scores: 6.50 ± 5.69 vs. 5.11 ± 4.85 vs. 4.78 ± 4.31, P = 0.049 and ICIQ SF scores: 2.92 ± 0.62 vs. 1.10 ± 0.36 vs. 1.13 ± 0.41, P < 0.001). A total of 17 (2.4%) perioperative and postoperative complications were observed on subjects.

Conclusion:

LSC using self-cut mesh could produce satisfactory results in pelvic organ prolapse patients on 6-month and 1-year follow-up period with minimal perioperative complications.
Predictors and potential risk factors of iatrogenic ureteral injury following common obstetric and gynecological surgeries: A single-center retrospective study
Authors: Ghazwani Yahya , Albogami Nasser , Aldwaighri Mohammed , Alhajress Ghassan , Alsaghyir Abdullah , Balaraj Faisal
Published: October 2024

Objectives:

As iatrogenic ureteral injury carries a high burden and is associated with increased postoperative morbidity and mortality, the purpose of this study is to determine the incidence and potential risk factors of iatrogenic ureteral injury following common obstetric and gynecological surgeries in King Abdulaziz Medical City.

Methods:

This was a single-center retrospective cohort study based on data extracted from an electronic hospital information system conducted in King Abdulaziz Medical City, Riyadh, Saudi Arabia. Three thousand four hundred and sixty-four cases of cesarean section (C-section) and hysterectomy from January 1, 2021, to December 31, 2022, were reviewed. All cases of C-section and hysterectomy in which the urology department was consulted for suspected iatrogenic ureteric injuries were included in the study. All cases other than C-sections and hysterectomy in which the urology department was consulted for suspected iatrogenic ureteric injuries were excluded from the study.

Results:

A total of 45 patients for whom urology was consulted for suspected ureteral injury were included in this study. Approximately (35.6%) one-third of the patients had positive findings of ureteral injury following common obstetric and gynecological surgeries. About 41.2% of these patients had previous gynecological surgeries. Other potential risk factors were tested such as age and body mass index. Older patients were slightly at higher risk of iatrogenic ureteral injury (P < 0.05).

Conclusion:

Ureteral injury in obstetric and gynecological surgeries is rare yet serious complication. The findings of this study suggest that the incidence of iatrogenic ureteral injury was relatively associated with older age.
Factor associated with postoperative complications of inguinal lymph node dissection for penile cancer Test
Authors: Likitpanpisit Phatsinee , Siriboonrid Satit
Published: October 2024

Background:

Inguinal lymph node dissection (ILND) is the standard of care for palpable, biopsy-proven lymph node metastases or high-risk groups for nonpalpable lymph nodes in the treatment of penile cancer. ILND is associated with a significant incidence of complications and adverse events, specifically wound complications. Few studies have identified risk factors related to postoperative ILND complications.

Objective:

The objective of this study was to assess the prevalence of 30-day postoperative complications and to identify risk factors associated with postoperative complications of ILND for penile cancer.

Materials and Methods:

This was a retrospective review of medical records for all patients who had ILND for penile cancer between January 2012 and December 2022. According to the modified Clavien–Dindo classification, the 30-day postoperative complications were collected. Using an ordinal univariate logistic regression model and multivariate analysis, potential risk variables for complications were determined.

Results:

A total of 60 patients were performed ILND. Sixty percent of the patients had a postoperative complication including wound infection 50%, wound dehiscence 36.7%, skin necrosis 26.6%, lymphocele 33.3%, leg edema 46.7%, and scrotal edema 16.7%. Higher grade of modified Clavien–Dindo classification was associated with body mass index (BMI) (odds ratio [OR] = 1.15; P = 0.03), diabetes mellitus (OR = 3.13; P = 0.04), American Society of Anesthesiologist classification ≥3 (OR = 1.14; P = 0.03), radical ILND (OR = 1.57; P = 0.01), and bilateral ILND (OR = 1.60; P = 0.02). In multivariate analysis, a higher grade of modified Clavien–Dindo classification was correlated with BMI (OR = 1.48; P = 0.01) and bilateral ILND (OR = 4.56; P = 0.01).

Conclusion:

ILND is associated with high rates of complication. The severity of the modified Clavien–Dindo classification was associated with BMI and bilateral ILND.
Local analog of the Deligne-Riemann-Roch isomorphism for line bundles in relative dimension 1
Authors: Osipov Denis Vasilievich
Published: October 2024

We prove a local analog of the Deligne-Riemann-Roch isomorphism in the case of line bundles and relative dimension $1$. This local analog consists in computation of the class of $12$th power of the determinant central extension of a group ind-scheme $\mathcal G$ by the multiplicative group scheme over $\mathbb Q$ via the product of $2$-cocyles in the second cohomology group. These $2$-cocycles are the compositions of the Contou-Carrère symbol with the $\cup$-product of $1$-cocycles. The group ind-scheme $\mathcal{G}$ represents the functor which assigns to every commutative ring $A$ the group that is the semidirect product of the group $A((t))^*$ of invertible elements of $A((t))$ and the group of continuous $A$-automorphisms of $A$-algebra $A((t))$. The determinant central extension naturally acts on the determinant line bundle on the moduli stack of geometric data (proper quintets). A proper quintet is a collection of a proper family of curves over $\operatorname{Spec} A$, a line bundle on this family, a section of this family, a relative formal parameter at the section, a formal trivialization of the bundle at the section that satisfy further conditions.
Models of representations for classical series of Lie algebras
Authors: Artamonov Dmitrii Vyacheslavovich
Published: October 2024

By a model of representations of a Lie algebra we mean a representation which is
a direct sum of all irreducible finite-dimensional representations taken
with multiplicity $1$. An explicit construction of
a model of representations for all classical series of simple Lie algebras
is given. This construction is generic for all classical series of Lie algebras.
The space of the model is constructed as the space of polynomial solutions of
a system of partial differential equations, where the equations are
constructed form relations between minors of matrices taken from
the corresponding Lie group. This system admits a simplification
very close to the GKZ system, which is satisfied
by $A$-hypergeometric functions.
Pfister forms and a conjecture due to Colliot-Thélène in the mixed characteristic case
Authors: Panin Ivan Alexandrovich , Tyurin Dimitrii Nikolaevich
Published: October 2024

Let $R$ be a regular local ring of mixed characteristic $(0,p)$, where $p\neq 2$ is a prime number.
Suppose that the quotient ring $R/pR$ is also regular. We fix a non-degenerate Pfister form $Q(T_{1},\ldots,T_{2^{m}})$ over $R$
and an invertible element $c$ in $R$. Then the equation $Q(T_{1},\ldots,T_{2^{m}})=c$ has a solution over $R$
if and only if it has a solution over the fraction field $K$.
Diabetes and obesity: A debate on bariatric interventions and its implications
Authors: Tatmatsu-Rocha José C , Lima da Silva Marcos R
Published: October 2024

In this editorial, we comment on an article by Tang et al published in the World Journal of Diabetes . Obesity and diabetes are two pathological situations that are intrinsically related. Neither lifestyle changes nor pharmacological treatments have achieved diabetes remission. From this perspective, bariatric surgery has been widely used as an approach for weight loss in obese patients and as a strategy to promote metabolic modulation. The main effects of bariatric surgery involve direct action in improving cardiovascular function and endothelial function and reducing insulin resistance, leading to diabetes remission in the short term following surgery. In this context, it has been observed that hormones from the gastrointestinal tract and endothelium play a prominent role in this process. By reversing endothelial dysfunction, it is possible to balance pro-inflammatory cytokine production, improving the availability of nitric oxide and inhibiting vascular oxidative stress. Furthermore, it can be considered an efficient anti-inflammatory strategy, alleviating interferon-gamma-mediated adipose tissue inflammation. The current challenge must be to unravel the pathophysiological mechanisms and potential targets for treating metabolic diseases.
Diabetes mellitus and comorbidities in elderly people from the Lugu community: A critical-reflective analysis
Authors: Tatmatsu-Rocha José Carlos , Gomes-Pinto José Carlos
Published: October 2024

Ageing has a close relationship with chronic non-communicable diseases, such as diabetes mellitus and high blood pressure. These pathologies are often associated with changes in eating habits and promote crucial physiological changes which act silently in the long term in the elderly population. Due to the speed of urban development and technological advances, there has been an increase in the population's life expectancy. However, it is essential to know the socio-demographic profile and prevalent comorbidities of the elderly population, which can provide a reliable and broad database to enable the outline of strategies and the promotion of efficient health policies. In this sense, the purpose of this editorial is to contribute to the debate surrounding the article that analysed epidemiological data from the Lugu community. Diabetes mellitus, hypertension and cardiovascular pathologies and their comorbidities were the most prevalent conditions in this community. Such data could contribute to develop public policies constructively and assertively, allowing investments in the prevention and treatment of these pathologies.
Glucagon-like peptide-1 agonists: Role of the gut in hypoglycemia unawareness, and the rationale in type 1 diabetes
Authors: Mirghani Hyder O
Published: October 2024

Type 1 diabetes is increasing and the majority of patients have poor glycemic control. Although advanced technology and nanoparticle use have greatly enhanced insulin delivery and glucose monitoring, weight gain and hypo-glycemia remain major challenges and a constant source of concern for patients with type 1 diabetes. Type 1 diabetes shares some pathophysiology with type 2 diabetes, and an overlap has been reported. The above observation created great interest in glucagon-like peptide-1 receptor agonists (GLP-1) as adjuvants for type 1 diabetes. Previous trials confirmed the positive influence of GLP-1 agonists on β cell function. However, hypoglycemia unawareness and dysregulated glucagon response have been previously reported in patients with recurrent hypoglycemia using GLP-1 agonists. Jin et al found that the source of glucagon dysregulation due to GLP-1 agonists resides in the gut. Plausible explanations could be gut nervous system dysregulation or gut microbiota disruption. This review evaluates the potential of GLP-1 agonists in managing type 1 diabetes, particularly focusing on their impact on glycemic control, weight management, and glucagon dysregulation. We provide a broader insight into the problem of type 1 diabetes mellitus management in the light of recent findings and provide future research directions.
Targeting neuronal PAS domain protein 2 and KN motif/ankyrin repeat domains 1: Advances in type 2 diabetes therapy
Authors: Cheng Chun-Han , Hao Wen-Rui , Cheng Tzu-Hurng
Published: October 2024

This editorial summarizes the latest literature on the roles of neuronal PAS domain protein 2 and KN motif/ankyrin repeat domain 1 in type 2 diabetes (T2D). We highlight their involvement in β-cell dysfunction, explore their potential as therapeutic targets, and discuss the implications for new treatment strategies. We offer valuable insights into relevant gene regulation and cellular mechanisms relevant for the targeted management of T2D.
Macrophages: Key players in diabetic wound healing
Authors: Zhou Xin , Guo Yan-Ling , Xu Chuan , Wang Jun
Published: October 2024

In this editorial, we discuss the article by Wen et al published. Diabetic foot ulcers are prevalent and serious complications of diabetes, significantly impacting patients’ quality of life and often leading to disability or death, thereby placing a heavy burden on society. Effective diabetic wound healing is hindered by an imbalance in macrophage polarization; many macrophages fail to transition from the pro-inflammatory M1 phenotype to the anti-inflammatory M2 phenotype, which is crucial for tissue remodelling and repair. The wound healing process is both dynamic and complex. Healthy M1 macrophages, which have strong phagocytic abilities, are vital during the inflammatory phase of diabetic wound healing. However, the failure to transition to M2 macrophages during the proliferative phase hinders wound healing. We anticipate the development of new therapies that can repair damaged M1 macrophages during the inflammatory phase and promote M2 macrophage polarization during the proliferative phase, thereby enhancing the overall healing process.
Effect of exercise during pregnancy on offspring development through ameliorating high glucose and hypoxia in gestational diabetes mellitus
Authors: Tang Yi-Bo , Wang Le-Sha , Wu Yi-Hui , Zhang Li-Xia , Hu Lu-Yao , Wu Qi , Zhou Meng-Lin , Liang Zhao-Xia
Published: October 2024

BACKGROUND

Gestational diabetes mellitus (GDM) women require prenatal care to minimize short- and long-term complications. The mechanism by which exercise during pregnancy affects organ development and whether glucose transporter (GLUT) 1 plays a role in GDM offspring organ development remains unknown.

AIM

To determine the effect of exercise during pregnancy on the cardiac, hepatic and renal development of GDM mother’s offspring.

METHODS

Placenta samples were collected from humans and mice. GDM mouse models were created using streptozotocin along with a GDM with exercise group. The hearts, livers and kidneys of 3- and 8-week-old offspring were collected for body composition analysis and staining. The effects of high glucose levels and hypoxia were investigated using HTR8/SVneo. Transwell and wound-healing assays were performed to assess cell migration. Immunofluorescence accompanied with TUNEL and Ki67 staining was used to explore apoptosis and proliferation.

RESULTS

Exercise during pregnancy downregulated the GLUT1 and hypoxia inducible factor-1α expression in placenta from individuals with GDM. Cobalt chloride-induced hypoxia and high glucose levels also significantly decreased migration and apoptosis of HTR8/SVneo cells. In addition, exercise reduced inflammatory cell infiltration in the liver and decreased the tubular vacuolar area in the kidneys of offspring.

CONCLUSION

GDM affects the growth and development of organs in offspring. Exercise during pregnancy can reverse adverse effects of GDM on the development of the heart, liver, and kidney in offspring.
Role of intestinal glucagon-like peptide-1 in hypoglycemia response impairment in type 1 diabetes
Authors: Cheng Chun-Han , Hao Wen-Rui , Cheng Tzu-Hurng
Published: October 2024

This study critically examines the novel findings presented by Jin et al , which explores the role of intestinal glucagon-like peptide-1 (GLP-1) in impaired counterregulatory responses to hypoglycemia in mice with type 1 diabetes. The study identifies intestinal GLP-1 as a significant determinant in the physiological responses to hypoglycemia, offering new insights into its potential implications for diabetes management. The editorial synthesizes these findings, discusses their relevance in the context of current diabetes research, and outlines potential avenues for future investigation of intestinal GLP-1 as a therapeutic target. This analysis underscores the need for continued research into the complex mechanisms underlying impaired hypoglycemia responses and highlights the potential of targeting intestinal GLP-1 pathways in therapeutic strategies for type 1 diabetes.
Glymphatic system function in diverse glucose metabolism states
Authors: Byeon Haewon
Published: October 2024

The rising prevalence of diabetes and prediabetes globally necessitates a deeper understanding of associated complications, including glymphatic system dysfunction. The glymphatic system, crucial for brain waste clearance, is imp-licated in cognitive decline and neurodegenerative diseases like Alzheimer’s disease. This letter explores recent research on glymphatic function across different glucose metabolism states. Tian et al ’s study reveals significant glym-phatic dysfunction in type 2 diabetes mellitus patients, evidenced by lower diffusion tensor imaging analysis along perivascular space indices compared to those with normal glucose metabolism and prediabetes. The research also reveals a link between glymphatic dysfunction and cognitive impairment. Additional research underscores the role of glymphatic impairment in neurodegenerative diseases. These findings highlight the importance of integrating glymphatic health into diabetes management and suggest potential biomarkers for early diagnosis and targeted therapeutic interventions.
Relationship between age and subfoveal choroidal thickness and its clinical implications
Authors: Sinha Sony , Nishant Prateek , Morya Arvind K , Singh Arshi
Published: October 2024

The retrospective study by Lei et al is an investigation of the relationship between age and subfoveal choroidal thickness (SFCT) in Chinese patients with proliferative diabetic retinopathy. Elements of the study design prevent the generalizability of the study findings, limiting their clinical implications. We recommend consideration of stricter eligibility criteria, other variables like duration of diabetes, interpretation of gender-differences in SFCT, longitudinal follow-up, use of newer choroidal flow indices, comparison of values with normal controls, subgroup analysis to determine the effect of prior treatment, as well as consideration of various real-world scenarios in future studies.
Bariatric and endo-bariatric interventions for diabetes: What is the current evidence?
Authors: Mondal Sunetra , Ambrose Fistus Vanessa , Pappachan Joseph M
Published: October 2024

Bariatric interventions have shown the best therapeutic benefits in individuals with obesity. They can be classified into surgical procedures (bariatric/metabolic surgery) and endoscopic procedures. Common surgical procedures include sleeve gastrectomy, Roux-en-Y gastric bypass, bilio-pancreatic diversion with or without duodenal switch and Stomach Intestinal Pylorus Sparing Surgery. Endoscopic procedures include intragastric balloons, transpyloric shuttle, endoscopic gastroplasties, aspiration therapy, duodenal mucosal resurfacing, duodeno-jejunal bypass liner, gastro-duodeno-jejunal bypass and incisionless magnetic anastomosis system among others. However, these procedures are limited by lack of wide availability, high costs, immediate and long-term complications and poor acceptability in some regions. Weight re-gain is a common concern and revisional metabolic surgery is often required. Appropriate pre-operative evaluation and correction of nutritional deficiencies post-surgery are very important. The most appropriate procedure for a person would depend on multiple factors like the intended magnitude of weight-loss, comorbidities and surgical fitness, as well as choice of the patient. Recently, glucagon-like insulinotropic peptide-1 receptor agonists (GLP) and the GLP-1/gastric inhibitory polypeptide co-agonist–Tirzepatide have shown remarkable weight loss potential, which is at par with bariatric interventions in some patients. How far these can help in avoiding invasive bariatric procedures in near future remains to be explored. An updated and comprehensive clinical review by He et al in the recent issue of World Journal of Diabetes address has addressed the avenues and challenges of currently available bariatric surgeries which will enable clinicians to make better decisions in their practice, including their applicability in special populations like the elderly and pediatric age groups, type 1 diabetes mellitus, and non-diabetics.
Stem cell exosomes: New hope for recovery from diabetic brain hemorrhage
Authors: Cheng Chun-Han , Hao Wen-Rui , Cheng Tzu-Hurng
Published: October 2024

Recent advancements in stem cell–derived exosome therapy for diabetic brain hemorrhage are discussed in this editorial, which highlights this therapy’s potential for revolutionizing diabetic brain hemorrhage treatment. The paper offers compelling evidence that exosomes can effectively reduce neuroinflammation and promote recovery from diabetic brain hemorrhage. Although these findings are promising, further research is warranted to fully understand the underlying mechanisms and to validate the therapeutic potential of exosomes in clinical settings. The findings of this study indicate that continued exploration should be conducted into exosome-based therapies as a novel approach to managing diabetic brain hemorrhage.
A brief overview of the past, present and future of the Global Earthquake Model (GEM) Foundation
Authors: Crowley Helen , Pagani Marco , Silva Vitor , Henshaw Paul , Schneider John , Smolka Anselm , Pinho Rui
Published: October 2024

The Global Earthquake Model (GEM) is an initiative that originally emerged from discussions and proposals made by the Global Science Forum of the Organization for Economic Co-operation and Development (OECD) in the early 2000’s. In 2009, GEM established itself as a non-profit legal entity, the GEM Foundation, and 15 years later, it continues to operate globally with a mission to provide transparent resources for seismic hazard and risk assessment, as well as to support disaster risk reduction for a wide range of natural hazards. This paper highlights the main milestones from the past 15 years and the vision of the foundation to 2030. An overview is also provided of the status of GEM products and services, all of which are made available for the benefit of society, under a strategy that aims to assure the continued financial sustainability of the organization.
Artista-Professor: Metodologia de ensino em arte
Authors: Clemente de Oliveira Gabriela
Published: October 2024

Neste trabalho são apresentadas metodologias criadas pelos artistas Guignard, Joseph Beuys, Cláudia Renault, Daniela Goulart, Marco Paulo Rolla e Sara Ávila, em suas práticas docentes na formação superior em arte. O princípio que norteou o estudo foi o potencial de ser o artista-professor, um indivíduo que possui saberes vindos da experiência em arte. Muito além da formação acadêmica, bacharelado ou licenciatura, o artista-professor é aquele que pode construir conhecimentos através da justa relação entre o fazer/criar e a reflexão sobre aquilo que se produz. Os artistas que compõem esse trabalho, demonstraram ser pessoas dotadas de conhecimentos sensíveis, capazes de proporcionar um ambiente particular na formação em arte. Assim como são múltiplos os saberes dos artistas, em função do complexo processo de criação em arte, múltiplas também se apresentaram suas metodologias.
Autocomposição: em perspectiva do conceito á eficiente concretização
Authors: Soares Duarte de Moura Rafael , Dreide Xavier Araújo Silva Vitória , Marques Farias Júnior Teddy , de Alencar Loyola Marajane , Soares Moran Talita , Xavier Brant Richardson
Published: October 2024

Este livro representa uma contribuição acadêmica significativa dedicada à análise dialética da autocomposição de conflitos, um tema que tem crescido em relevância na sociedade contemporânea. A obra consiste em uma coleção de capítulos, redigidos por especialistas e acadêmicos, que investigam a autocomposição a partir de múltiplas perspectivas. Através de uma análise crítica e detalhada, os capítulos oferecem uma exploração abrangente das aplicações da autocomposição em contextos diversos, que abrangem desde o sistema judiciário até a esfera educacional e a saúde mental. Cada capítulo deste livro proporciona um olhar específico e enriquecedor sobre como a autocomposição pode ser útil como meio de resolução justa e eficaz de conflitos em uma diversidade de cenários. A obra é destinada não apenas a um público acadêmico, mas também a profissionais, estudantes e todos aqueles que se interessam pelo entendimento sobre as nuances envolvidas na autocomposição, possibilitando compreender como ela pode ser uma ferramenta substancial na promoção de sociedades mais justas e harmoniosas.
Caminhos do desenvolvimento: Vol. 1. Desenvolvimento Social
Authors: Fróes Couto Felipe , Matheus da Silva Cruz Júnio , Marques Farias Júnior Teddy , Dreide Xavier Araújo Silva Vitória
Published: October 2024

Trata-se de uma coletânea lançada conjuntamente pelo Programa de Pós-Graduação em Desenvolvimento Social (PPGDS) e Programa de Pós-Graduação Profissional em Desenvolvimento Econômico e Estratégia Empresarial (PPGDEE), ambos da Universidade Estadual de Montes Claros (UNIMONTES). A coletânea visa reunir produções que retratem a inteligência científica em desenvolvimento social e econômico de autores do Brasil e do Exterior, com leituras que retratam avanços sobre o tema. Esta obra se destaca por sua abordagem abrangente e diversificada, dedicando-se à análise criteriosa dos avanços alcançados nos estudos sobre desenvolvimento, explorando uma variedade de perspectivas de maneira integrada.
The Making of Roman Lead Ingots. Their Casting by Experiment and the Archaeological Evidence
Authors: Hanel Norbert , Pfeffer Ingo
Published: October 2024

Casting experiments in Brilon-Hoppecke (North Rhine-Westfalia, Germany) in 2011 and 2012 as well as in 2015 aimed to reconstruct  the production of Roman lead ingots with the help of archaeological experiments on the one hand; on the other hand, traces of the  moulding process on the Roman lead ingots themselves and the epigraphic evidence were examined to provide further information on the production process. The results of this research, suggest that most of the lead ingots were very likely cast in clay sand moulds  which almost completely disintegrated after the ingots had been removed. In a few cases, wood could be verified as the material for the moulds. Finally, all known artefacts associated with the casting of lead ingots have been critically examined and reinterpreted.
La Construcción y consolidación de la paz: acciones en el marco de la responsabilidad social de las mipymes en colombia
Authors: Fragozo Manjarrez Obed Alfonso , Giraldo Gutiérrez Francisco Luis
Published: October 2024

This article is the result of one of the objectives formulated in the research project, developed between the Minuto de Dios University Corporation - UNIMINUTO, Bogotá headquarters, the ITM Higher Education Institution of Medellín and the National Institute of Professional Technical Training - INFOTEP of San Juan del César (La Guajira), which seeks to propose Corporate Social Responsibility (CSR) strategies for MSME that encourage the linkage of these organizations to peace-building actions from the territory. It starts from the question: What are the actions within the framework of social responsibility, carried out by MSME, that enable the construction and consolidation of Peace in their territories? The reference places, the Metropolitan Area of Medellín, the municipality of San Juan del César and the municipality of Aguazul (Casanare), were taken into account as analysis scenarios. The topic of Social Responsibility for MSME is framed, in an analytical and descriptive manner, in the components presented by the ISO 26000 standard (ISO, 2010), and the lines of action formulated in the 2016 Peace agreement between the government of President of Colombia, Juan Manuel Santos and the extinct FARC Guerrilla (today the Comunes party) in Colombia. Based on the findings obtained, the business actions that are formulated in a CSR Plan must seek to deepen their relationship with the environment, positively impacting a stable and lasting construction of peace.
ANALISIS PENGGUNAAN AUDIO MUROTTAL DALAM MEMBANTU MURAJA’AH DAN DAMPAKNYA TERHADAP KUALITAS HAFALAN AL-QUR’AN SANTRI PONDOK PESANTREN TAHFIZH YAYASAN WAKAF SURRO MAN ROA
Authors: Fitri Ginting Rahmadani , Ar Rasyid Harun , Yulia Mulan Isnu , Ramadhan Harmansyah
Published: October 2024

Menghafal Al-Qur’an tidak lepas dari muraja’ah setiap harinya. Ada berbagai macam cara untuk melakukan muraja’ah, salah satunya adalah dengan memanfaatkan audio murottal. Penelitian ini bertujuan untuk mengeksplorasi bagaimana penggunaan audio murottal dapat membantu muraja’ah dan dampaknya terhadap kualitas hafalan Al-Qur’an. Penelitian ini merupakan penelitian lapangan dengan pendekatan deskriptif kualitatif. Data diperoleh melalui observasi, wawancara dan tes yang kemudian dianalisis menggunakan analisis tematik serta triangulasi sebagai validasi data. Hasil penelitian ini menunjukkan bahwa penggunaan audio murottal secara signifikan mendukung santri dalam proses muraja'ah, meningkatkan fokus dan keterlibatan mereka, serta berperan penting dalam peningkatan kualitas hafalan Al-Qur'an. Meskipun terdapat tantangan dalam penerapannya, akan tetapi penggunaan audio murottal dinilai sangat positif sebagai alat bantu muraja’ah dan penguatan hafalan. Penelitian ini memberikan penguatan perspektif mengenai metode yang efektif dalam pengajaran Al-Qur'an, dan diharapkan dapat menjadi acuan bagi lembaga pendidikan Islam dalam merumuskan strategi pembelajaran yang lebih optimal.
Effectiveness of Antifungal Treatment for Onychomycosis
Authors: Samanta Adelina Lorena
Published: October 2024

Onychomycosis is a prevalent fungal infection of the nails, which causes thickening, discoloration, and detachment of the nail bed. The condition is mainly caused by various fungal species, including dermatophytes, yeasts and molds. Treatment of onychomycosis is complex, with antifungal drugs playing a key role. This research aimed to evaluate the effectiveness of various antifungal treatments, both topical and systemic, in managing onychomycosis. This research used a descriptive qualitative approach, using secondary data through documentation analysis. Data were triangulated to increase reliability and validity. The findings showed that the effectiveness of antifungal treatment varied depending on the type of drug, duration of treatment, and patient compliance. Systemic antifungals, such as terbinafine and itraconazole, showed higher cure rates compared to topical treatments such as ciclopirox and amorolfine. However, all treatments had high relapse rates, underscoring the need for continuous monitoring and customized therapy. The implications of this research demonstrate the importance of personalized treatment plans and the development of strategies to prevent relapse, which remains a significant challenge in the management of onychomycosis.
Effect of Immersion of Denture Base Thermoplastic Nylon in Alkaline Peroxide and 10% Castor Oil (Ricinus Communis Oil) on Color Stability and Flexural Strength
Authors: Welda Utami Putri , Asti Nafisah Lubis Hana , Hartati Marbun Astri
Published: October 2024

Discoloration and flexural strength of denture bases are important factors affecting the comfort and durability of denture users. This study aims to determine the effect of immersion of nylon thermoplastic denture base in alkaline peroxide solution and 10% castor oil (Ricinus Communis Oil) on color stability and flexural strength. This study used a laboratory experimental design with samples of cylindrical (20 x 2 mm) thermoplastic nylon resin for color stability test and rectangular (65 x 10 x 3 mm) for flexural strength test. There were two study groups: one control group and two treatment groups immersed in alkaline peroxide and 10% castor oil solution, with two time variables, 8 days and 12 days. The total number of samples was 60, with each group having 10 samples. The color stability test used a colorimeter, and the flexural strength test used a universal testing machine. The results showed that there was no effect of soaking the nylon thermoplastic denture base in alkaline peroxide on color stability, with a value of p = 0.412 for 8 days and p = 0.179 for 12 days. In addition, there was no effect of immersion in alkaline peroxide and 10% castor oil on flexural strength, with p value = 0.076 for 8 days and p = 0.917 for 12 days. The implication of this study is that immersion in alkaline peroxide and castor oil solution does not affect the color stability or flexural strength of nylon thermoplastic denture bases, making them safe for long-term use.
The evolution of agricultural areas in a Saharan region by satellite imagery (landsat, sentinel) case of the Oued Righ region, Algeria
Authors: Belaiche Karima , Boumaraf Belkacem
Published: October 2024

During this study, our objective was to systematically identify predominant spatiotemporal trends related to the evolution of agricultural perimeters in a Saharan region, specifically the oases of Oued Righ in Algeria. To achieve this, we used satellite imagery data. The chronological sequence of satellite images covering the Oued Righ region, situated in the Northeastern Sahara of Algeria, was meticulously established. Spatial remote sensing proved to be an essential tool, providing us with up-to-date and geo-referenced data regarding vegetation. We used  a time series of Landsat (8, 4-5, 7) and Sentinel 2 images covering Oued Righ from 1984 to 2024, using bands 4, 3, 2, and 5, 4, 3 infrared. These images offered precise insights into the actual vegetation development in the study area, eliminating any guesswork. Our analysis relied on vegetation indices, notably the NDVI (Normalized Difference Vegetation Index), allowing us to objectively and scientifically monitor the evolution of this perimeter.
Aplicaciones de la IA en la enseñanza de habilidades de búsqueda de Información: Modelo TPACK
Authors:   Universidad de San Carlos de Guatemala, Ruíz Mangandi Ruth Noemy
Published: October 2024

OBJETIVO: Analizar las aplicaciones de la Inteligencia Artificial (IA) en la enseñanza de habilidades de búsqueda de información, mediante el enfoque del Modelo TPACK (Tecnología, Pedagogía y Conocimiento de Contenido). MÉTODO: Revisión bibliográfica. Se realizó una revisión de literatura académica y profesional relacionada con uso de la Inteligencia Artificial (IA) en la enseñanza de habilidades de búsqueda de información, así como el Modelo TPACK (Tecnología, Pedagogía y Conocimiento de Contenido) en el ámbito educativo. RESULTADOS: Se encontró que la aplicación del Modelo TPACK ha sido efectiva en la construcción de nuevas herramientas digitales, como la aplicación AWSPC, impulsando así la capacidad de los educadores para enseñar habilidades de búsqueda de información de manera eficaz. CONCLUSIÓN: La integración de la Inteligencia Artificial en la enseñanza de habilidades de búsqueda de información se muestra prometedora para mejorar las condiciones de enseñanza-aprendizaje al proporcionar a los educadores herramientas más efectivas y centradas en el estudiante, siempre y cuando sea promovida con conciencia y ética.
El modelo TPACK: el impacto de integrar las TIC en el aprendizaje de destrezas numéricas
Authors:   Universidad de San Carlos de Guatemala, Vásquez Cifuentes Paula María
Published: October 2024

OBJETIVO: Establecer el impacto de la implementación del modelo TPACK en el desarrollo de competencias numéricas. MÉTODO: Revisión bibliográfica en tres bases de datos y fuentes de información relevantes, principalmente: Scielo, Redalyc y ResearchGate; por medio de criterios de inclusión y exclusión. RESULTADOS: Todos los estudios reflejaron resultados positivos en cuanto a la implementación del modelo TPACK en el desarrollo de competencias numéricas, considerando diversos aspectos como la percepción del estudiante, la formación docente en la metodología, y sobre todo, la disposición del docente para aplicar el modelo. CONCLUSIÓN: La implementación del modelo TPACK en el contexto educativo de las disciplinas numéricas se evidenció como exitosa en todos los estudios revisados; el aspecto de mayor recurrencia, que destacó en su aplicación fue la relevancia del desarrollo profesional del educador en el modelo TPACK.
Problems in Medicine and Health Care in Karakalpakstan During the World War II
Authors: Gulmurat Allamuratov
Published: October 2024

The article discusses the widespread prevalence of infectious intestinal diseases and parasitic typhus among the urban and rural population of Karakalpakstan during the years of World War II. It also highlights the frequent occurrence of urban doctors recording deaths from acute respiratory diseases (such as influenza and measles), as well as tuberculosis and gastrointestinal diseases (such as dysentery and hemocolitis). Regarding the heads of the sanitary-epidemiological stations (in Nukus, Chimbay, Tortkol, Muynak, and others), it is emphasized that they worked not out of fear, but conscientiously, without regard for time and effort, as expected during the wartime period. During the war years, the attitude of urban populations toward modern medicine improved significantly. It highlights that doctors such as U. Khalmuradov, V. V. Voskoboynikov, V. P. Khaneeva, A. V. Poltoratsky, I. G. Lepeshkin, E. G. Ridaeva, S. Alimov, and others gained great respect and worked diligently among the population.
A relação de estudantes na graduação com a prática de escrita no gênero Artigo Científico
Authors: Madureiro Maria do Carmo Carvalho , Almeida Larissa Naiara Souza de , Silva Esequias Rodrigues da , Dieb Messias
Published: October 2024

A escrita de artigos científicos desempenha papel central para que estudantes universitários desenvolvam suas identidades como acadêmicos e consigam se expressar. Este artigo apresenta uma pesquisa qualitativa no âmbito de um curso de Licenciatura em Pedagogia e foca na produção do artigo científico em uma disciplina obrigatória do curso. Por meio da técnica de Instrução ao sósia (Oddone; Ré; Briante, 2008), os participantes foram instigados a autorrefletir e descrever o processo de produção de um artigo científico. Utilizamos a análise de conteúdo e obtivemos três categorias: 1) a aprendizagem de elementos formais do texto; 2) a busca de referência textual em modelos de artigo; e por último 3) o desejo de participação em práticas de letramento da comunidade acadêmica. Como contribuição deste trabalho, é possível destacar reflexões sobre a escrita de artigos científicos por estudantes que estão no início da construção de uma identidade acadêmica de escritor.
Narrativa de escolarização de uma trans no Noroeste Paulista
Authors: Silva Éder Junio da , Silva Fernando Guimarães Oliveira da
Published: October 2024

Este artigo apresenta parte dos resultados de uma pesquisa de mestrado em educação, desenvolvida junto à Universidade Estadual de Mato Grosso do Sul UEMS – Unidade de Paranaíba/MS. O objetivo é apresentar e analisar o relato de escolarização de Samantha[1], uma mulher trans do Noroeste Paulista, abordando questões de educação e transexualidade. Para cumprir esse objetivo, foi utilizada uma metodologia qualitativa de abordagem pós-crítica, por meio de uma entrevista em profundidade semiestruturada. Os resultados da entrevista revelam vários pontos de tensão e conflito em relação a um conjunto de mecanismos heteronormativos na escola, incluindo experiências de rejeição e exclusão tanto por parte da família quanto da escola, e as consequências negativas desses fatores em sua trajetória de vida, processos de subjetivação e identificação.
Safety and Efficacy of Multisession Gamma Knife Radiosurgery for (Large Benign Intracranial Lesions > 3cm)
Authors:   M.B.Ch.B, F.I.C.M (neurosurgery), Lecturer/neurosurgeon at Al- Kufa university-college of medicine, Al-Sader medical city, Najaf, Iraq, Zuhair Sarah , Hasan Hamandi Yasir Mohammed ,   M.B.Ch.B/F.I.C.M.S (neurosurgery), Professor/consultant Neurosurgeon, Gamma knife department at Saad Al wittry Neuroscience Hospital & Al-Nahrain university-college of medicine, Baghdad, Iraq
Published: October 2024

Background: Stereotactic radiosurgery is delivery of an ablative dose of ionizing radiation to a focused target with 3D localization to elicit a specific radiobiological response and sparing the surrounding normal brain tissue. Objective: to evaluate safety and efficacy of Gamma knife radiosurgery by volume staging of large benign intracranial lesions. Patients and methods: prospective cohort study is conducted at Saad Alwitry neuroscience hospital, gamma knife department between June 2017 to February 2021, 60 patients (25 case meningioma ,15 case vestibular schwannoma ,10 case arteriovenous malformation and 10 patients with pituitary macro-adenoma) having large lesions of >3cm were treated by multisession radiosurgery (2-3 sessions), time between sessions (24hr-6m), follow up time ranged from(6ms-3yr). Results: rate of growth control for meningioma, vestibular schawannoma, AVM and pituitary macro-adenoma was 76 %,53.3% ,30% and 60% while reduction in lesion size is 20%, 33.3%, 70% and 30% respectively and clinical improvement was 86.4% for meningioma ,52.6% for VS ,73.2% for AVM and 88% for PA and the complications reported were 15.2%. Conclusion: volume staged multisession GKSR is effective, safe and well tolerated with low morbidity modality for these large lesions.
Study of Unlawful Acts in the Implementation of Fiduciary Execution (Verdict Study No.345/pdt.g/218/PN jkt.sel)
Authors:   Faculty of Law, Pancasila University, Indonesia, Alfaribi Ahmad Taher Ridwan , Setiawan I Ketut Oka ,   Faculty of Law, Pancasila University, Indonesia
Published: October 2024

As a form of security derived from law, fiduciary security has been used in Indonesia since the Dutch colonial era. Although the procedure is considered quick, easy, and uncomplicated, this type of collateral is often used in lending and borrowing transactions. Still, it does not provide legal certainty for creditors in their capacity as fiduciary beneficiaries. The author specializes in normative legal research, which is sometimes referred to as doctrinal legal research. Field research is not recognized in normative legal research. Research that looks at laws that are produced and organized based on doctrines that have been accepted by their developers or conceptors is known as doctrinal legal research. The judge granted the plaintiff's claim in counterclaim. The Judge stated that the Defendant in the counterclaim had defaulted to the Plaintiff in the counterclaim. Due to illegal behavior and violation of the subjective rights of others that are legally protected, the defendants' actions can be qualified as unlawful acts.
Workplace Spirituality as a Moderator of the Influence of Task Complexity, Audit Experience and Audit Competence on Auditor Performance (Case Study of Public Accounting Firm of Bali Province)
Authors:   Udayana University, Denpasar-Indonesia, Dinata I Gede Arya Mahendra , Budiasih I G.A.N ,   Udayana University, Denpasar-Indonesia
Published: October 2024

Auditor performance is the result of work achieved by an auditor in carrying out his duties in accordance with the responsibilities given. This research was conducted at Public Accounting Firms (KAP) in Bali Province based on the Directory of Public Accounting Firms and Public Accountants published by the Indonesian Institute of Public Accountants (IAPI) in 2023. The subject to be studied is an auditor who is in a Public Accounting Firm (KAP) in Bali Province. The population in this study is all auditors in the Public Accounting Firm (KAP) of Bali Province which totals 148 people. The number of auditors was 148 people obtained by asking directly to the Public Accounting Firm (KAP) in Bali Province. The sample determination method used in this study is saturated sampling. The data collection method used in this study is a survey method with a questionnaire technique. The respondents' statement answers were measured using a 5-point likert scale. The data analysis in this study uses the Moderated Regression Analysis (MRA) approach. Moderated Regression Analysis (MRA) is a data analysis method that is devoted to analyzing moderation variables with the help of the Stata application. The results of this study prove that the complexity of tasks has a negative effect on the performance of auditors in Public Accounting Firms in Bali Province. Audit experience has a positive effect on the performance of auditors in Public Accounting Firms in Bali Province. Audit competence has a positive effect on the performance of auditors in Public Accounting Firms in the Province of Bali. In addition, this study also proves that Workplace Spirituality strengthens the negative relationship between task complexity and auditor performance in Public Accounting Firms in Bali Province. Workplace spirituality strengthens the positive relationship of audit experience to auditor performance in Public Accounting Firms in Bali Province. Workplace spirituality strengthens the positive relationship between audit competence and auditor performance in Public Accounting Firms in Bali Province.