bluuebunny/crossref_metadata_2025 huggingface dataset:
Multifaceted Role of Tiliroside in Inflammatory Pathways: Mechanisms and Prospects
Authors: Kaur Gurjeet , Kaur Jasleen , Goyal Jayant , Vaid Lavish , Singh Thakur Gurjeet , Singh Randhir , Devi Sushma
Published: October 2024

Tiliroside, a natural polyphenolic compound found in several plant sources, has garnered
attention for its potential to mitigate inflammation and its associated diseases. The current
review explores the multifaceted functions of Tiliroside in inflammation-related diseases, delving
into the underlying mechanisms and prospects for therapeutic applications. Tiliroside exerts
its anti-inflammatory effects through a variety of mechanisms, such as the inhibition
of inflammatory mediators’ cytokines and chemokines, as well as the suppression of nuclear
factor-kappa B (NF-κB) signaling pathways. Additionally, it demonstrates potent antioxidant
properties, which further contribute to its anti-inflammatory activity by reducing oxidative
stress. In preclinical studies, Tiliroside has shown promising results in ameliorating inflammation
in conditions like rheumatoid arthritis, inflammatory bowel disease, and atherosclerosis.
Furthermore, Tiliroside's ability to modulate immune responses and stimulate tissue regeneration
contributes to its potential as a multimodal agent in treating inflammation-associated disorders.
In conclusion, Tiliroside emerges as a promising natural compound with a multifaceted
role in inflammation-related diseases with understanding the underlying mechanisms of its therapeutic
prospects may pave the way for novel treatments.
Effects of copper prices volatility on Peruvian economics: empirical evidence from TVP-VAR-SV models
Authors: Muñoz Aguilar Jose Carlos
Published: October 2024

Considering the strong performance of copper prices in the past few years and the dependence on this mineral for Peru, this research was developed. with the objective to analyze the effects of copper prices volatility on these main macroeconomic variables. For this are proposed a TVP-VAR-SV model. The results indicate that a 1% rise in copper prices leads to a corresponding increase of 0.03% in GDP growth, an increases of 3.77% in exports and a decrease of 1.22% in exchange rate, on average, within the first quarter following the price change. However, it can be seen how the effects are amplified in periods of high volatility in the price of copper. In 2009Q4, these effects are amplified, where the GDP increases by 0.69%, exports increase by 5.86% and the exchange rate decreases up to 1.69%.
10 años de la Iniciativa de la Franja y la Ruta (IFR) como estrategia de desarrollo de infraestructura global y cooperación internacional impulsada por la República Popular China
Authors: Valdiglesias Oviedo Jhon , Lazo Cervantes Kiara Lizeth
Published: October 2024

La finalidad de este estudio es examinar las tendencias de la inversión china dentro del contexto de la Iniciativa de la Franja y la Ruta (IFR); además de reconocer las oportunidades que surgen para América Latina. Para ello, se recopiló la literatura que sintetiza las relaciones entre estas dos economías. Asimismo, se recurrió a diversas fuentes de información para evaluar los proyectos chinos en diversas regiones y compararlos con los de América Latina. Los resultados confirman un fuerte dinamismo de China, aunque recientemente suavizado por una mayor adversidad al riego. A su vez, hay un importante impulso con algunas grandes inversiones en la región; sobre todo en Sudamérica. Se concluye que la región posee condiciones favorables para capitalizar las oportunidades generadas por la IFR.
Crítica de la Economía Política de David Ricardo. De la teoría del valor a la teoría del comercio internacional
Authors: Ojeda Cardenas Juan Narciso
Published: October 2024

El libro Crítica de la Economía Política de David Ricardo: de la teoría del valor a la teoría del comercio internacional destaca la solvencia intelectual de su autor, Pedro Arjón López, cuyo mérito radica en identificar errores y omisiones en la obra de un autor clásico como David Ricardo, aspectos que otros estudiosos de renombre han pasado por alto. La excepcional preocupación teórica de Arjón para desentrañar los secretos de la economía y su revisión crítica de autores consagrados le permiten encontrar diferencias, semejanzas, problemas y cambios de paradigmas que también se reflejan en la ciencia económica. Esta notable competencia ha quedado demostrada en su labor académica en la Universidad del Mar (UMAR) de México y en otros centros educativos. Cabe mencionar que el Dr. Arjón también publicó un artículo en la prestigiosa revista Investigación Económica de la Facultad de Economía de la UNAM, titulado "La teoría de la Utilidad de David Ricardo" (Investigación Económica, Vol. XLV, 256, octubre-diciembre de 2006, pp. 161-193), el cual representa un antecedente importante para este libro.
Animal de letras IV: Páginas perdidas
Authors: Storni Alfonsina
Published: October 2024

En esta invitación, abrimos las puertas al fascinante mundo de Alfonsina Storni, una autora cuya presencia en la literatura sudamericana es imborrable. Su legado trasciende el tiempo, resonando en cada página. Nos sumergimos en la profundidad des u obra, esperando que cada palabra provoque una conmoción, que cada verso despierte emociones genuinas y profundas.
FUNDUS IMAGE CLASSIFICATION USING HYBRIDIZED GLCM FEATURES AND WAVELET FEATURES
Authors:   Sona College of Technology, India, T Shanthi , R S Sabeenian ,   Sona College of Technology, India, K Manju ,   Sona College of Technology, India, M E. Paramasivam ,   Sona College of Technology, India, P.M. Dinesh ,   Sona College of Technology, India, R Anand ,   Sona College of Technology, India
Published: October 2024

We find the usefulness of computers in every field including medical field. Scanning the affected part has become a standard study. Diagnosing a disease at the right time, i.e. early detection, from the study of images enables the physician to take right decision and provide proper treatment to the patient. With the alarming growth of population, it is difficult for every individual patient to get a second opinion from medical expert. In these situations, computer-aided automatic diagnosis system will be much helpful. Diabetic retinopathy is a disorder that arises from increase in blood glucose level. Based on the severity, it has been distinguished into four stages. Diagnosing diabetic retinopathy at an early stage from retinal images and providing proper treatment will save the patient from severe vision loss. The proposed method adopts hybridized GLCM features and wavelet features to classify the fundus images according to the severity of the disease. The method is tested with fundus images collected from Indian Diabetic Retinopathy Dataset.
EVALUATION OF IMPROVED FUZZY INFERENCE SYSTEM TO PRESERVE IMAGE EDGE FOR IMAGE ANALYSIS
Authors:   I.K. Gujral Punjab Technical University, India, Prakram Manu , Singh Amanpreet ,   I.K. Gujral Punjab Technical University, India, Singh Jagroop ,   DAV Institute of Engineering and Technology, India
Published: October 2024

There are numerous applications based on edge detection have been used in the area of image analysis. The technique of edge detection is an important step towards the visual system reliability and security that delivers a better understanding in many applications like object recognition classification, photography, and many more others computer vision application such as pedestrian detection for a vehicle on the road, face detection in biometric, and video surveillance. We know that detection of edge detection is a scientific technique that is practiced to provide better image analysis and towards this purpose, lots of edge identification approach was already implemented by the researchers in the image processing era, but they do not achieve acceptable results for all types of the image that can help in the image analysis. In this research, we introduced a comparative evaluation of edge detection algorithms for instance Sobel, Canny, and Fuzzy logic-based edge detector with an Improved Fuzzy Inference (IFI) system is presented to preserve image edge for image analysis. The key contribution of this research is developing a new hybrid edge mechanism by utilizing the gradient and standard deviation based fuzzy logic approach to achieve better edge detection efficiency. To provide a better edge or non-edge region from an image the proposed IFI has its impact on quality parameters, for instance, Peak Signal to Noise Ratio (PSNR), Mean Square Error (MSE), Entropy and Structural Similarity (SSIM) with the execution time. At last, the performance parameters of the proposed IFI system is compared with other edge technique and we observed that the achieved results justify the proposed work in image processing.
Targeting Key Risk Factors for Cardiovascular Disease in At-Risk Individuals: Developing a Digital, Personalized, and Real-Time Intervention to Facilitate Smoking Cessation and Physical Activity
Authors: Versluis Anke , Penfornis Kristell M , van der Burg Sven A , Scheltinga Bouke L , van Vliet Milon H M , Albers Nele , Meijer Eline
Published: October 2024

Health care is under pressure due to an aging population with an increasing prevalence of chronic diseases, including cardiovascular disease. Smoking and physical inactivity are 2 key preventable risk factors for cardiovascular disease. Yet, as with most health behaviors, they are difficult to change. In the interdisciplinary Perfect Fit project, scientists from different fields join forces to develop an evidence-based virtual coach (VC) that supports smokers in quitting smoking and increasing their physical activity. In this Viewpoint paper, intervention content, design, and implementation, as well as lessons learned, are presented to support other research groups working on similar projects. A total of 6 different approaches were used and combined to support the development of the Perfect Fit VC. The approaches used are (1) literature reviews, (2) empirical studies, (3) collaboration with end users, (4) content and technical development sprints, (5) interdisciplinary collaboration, and (6) iterative proof-of-concept implementation. The Perfect Fit intervention integrates evidence-based behavior change techniques with new techniques focused on identity change, big data science, sensor technology, and personalized real-time coaching. Intervention content of the virtual coaching matches the individual needs of the end users. Lessons learned include ways to optimally implement and tailor interactions with the VC (eg, clearly explain why the user is asked for input and tailor the timing and frequency of the intervention components). Concerning the development process, lessons learned include strategies for effective interdisciplinary collaboration and technical development (eg, finding a good balance between end users’ wishes and legal possibilities). The Perfect Fit development process was collaborative, iterative, and challenging at times. Our experiences and lessons learned can inspire and benefit others. Advanced, evidence-based digital interventions, such as Perfect Fit, can contribute to a healthy society while alleviating health care burden.
Construction and Application of a Private 5G Standalone Medical Network in a Smart Health Environment: Exploratory Practice From China
Authors: Chen Baozhan , Shi Xiaobing , Feng Tianyi , Jiang Shuai , Zhai Yunkai , Ren Mingxing , Liu Dongqing , Wang Chengzeng , Gao Jinghong
Published: October 2024

Background

To date, the differentiated requirements for network performance in various health care service scenarios—within, outside, and between hospitals—remain a key challenge that restricts the development and implementation of digital medical services.

Objective

This study aims to construct and implement a private 5G (the 5th generation mobile communication technology) standalone (SA) medical network in a smart health environment to meet the diverse needs of various medical services.

Methods

Based on an analysis of network differentiation requirements in medical applications, the system architecture and functional positioning of the proposed private 5G SA medical network are designed and implemented. The system architecture includes the development of exclusive and preferential channels for medical use, as well as an ordinary user channel. A 3-layer network function architecture is designed, encompassing resource, control, and intelligent operation layers to facilitate management arrangements and provide network open services. Core technologies, including edge cloud collaboration; service awareness; and slicing of access, bearer, and core networks, are employed in the construction and application of the 5G SA network.

Results

The construction of the private 5G SA medical network primarily involves system architecture, standards, and security measures. The system, featuring exclusive, preferential, and common channels, supports a variety of medical applications. Relevant standards are adhered to in order to ensure the interaction and sharing of medical service information. Security is achieved through mechanisms such as authentication, abnormal behavior analysis, and dynamic access control. Three typical medical applications that rely on the 5G network in intrahospital, interhospital, and out-of-hospital scenarios—namely, mobile ward rounds, remote first aid, and remote ultrasound—were conducted. Testing of the 5G-enabled mobile ward rounds showed an average download rate of 790 Mbps and an average upload rate of 91 Mbps. Compared with 4G, the 5G network more effectively meets the diverse requirements of various business applications in prehospital emergency scenarios. For remote ultrasound, the average downlink rate of the 5G network is 4.82 Mbps, and the average uplink rate is 2 Mbps, with an average fluctuation of approximately 8 ms. The bandwidth, performance, and delay of the 5G SA network were also examined and confirmed to be effective.

Conclusions

The proposed 5G SA medical network demonstrates strong performance in typical medical applications. Its construction and application could lead to the development of new medical service models and provide valuable references for the further advancement and implementation of 5G networks in other industries, both in China and globally.
Construction and Application of a Private 5G Standalone Medical Network in a Smart Health Environment: Exploratory Practice From China (Preprint)
Authors: Chen Baozhan , Shi Xiaobing , Feng Tianyi , Jiang Shuai , Zhai Yunkai , Ren Mingxing , Liu Dongqing , Wang Chengzeng , Gao Jinghong
Published: October 2024

BACKGROUND

To date, the differentiated requirements for network performance in various health care service scenarios—within, outside, and between hospitals—remain a key challenge that restricts the development and implementation of digital medical services.

OBJECTIVE

This study aims to construct and implement a private 5G (the 5th generation mobile communication technology) standalone (SA) medical network in a smart health environment to meet the diverse needs of various medical services.

METHODS

Based on an analysis of network differentiation requirements in medical applications, the system architecture and functional positioning of the proposed private 5G SA medical network are designed and implemented. The system architecture includes the development of exclusive and preferential channels for medical use, as well as an ordinary user channel. A 3-layer network function architecture is designed, encompassing resource, control, and intelligent operation layers to facilitate management arrangements and provide network open services. Core technologies, including edge cloud collaboration; service awareness; and slicing of access, bearer, and core networks, are employed in the construction and application of the 5G SA network.

RESULTS

The construction of the private 5G SA medical network primarily involves system architecture, standards, and security measures. The system, featuring exclusive, preferential, and common channels, supports a variety of medical applications. Relevant standards are adhered to in order to ensure the interaction and sharing of medical service information. Security is achieved through mechanisms such as authentication, abnormal behavior analysis, and dynamic access control. Three typical medical applications that rely on the 5G network in intrahospital, interhospital, and out-of-hospital scenarios—namely, mobile ward rounds, remote first aid, and remote ultrasound—were conducted. Testing of the 5G-enabled mobile ward rounds showed an average download rate of 790 Mbps and an average upload rate of 91 Mbps. Compared with 4G, the 5G network more effectively meets the diverse requirements of various business applications in prehospital emergency scenarios. For remote ultrasound, the average downlink rate of the 5G network is 4.82 Mbps, and the average uplink rate is 2 Mbps, with an average fluctuation of approximately 8 ms. The bandwidth, performance, and delay of the 5G SA network were also examined and confirmed to be effective.

CONCLUSIONS

The proposed 5G SA medical network demonstrates strong performance in typical medical applications. Its construction and application could lead to the development of new medical service models and provide valuable references for the further advancement and implementation of 5G networks in other industries, both in China and globally.
Occurrence of Stigmatizing Documentation Among Hospital Medicine Encounters With Opioid-Related Diagnosis Codes: Cohort Study (Preprint)
Authors: Bradford William S , Bratches Reed W R , Porras Hollie , Chen David R , Gagnon Kelly W , Ascher Simon B
Published: October 2024

BACKGROUND

Physician use of stigmatizing language in the clinical documentation of hospitalized adults with opioid use is common. However, patient factors associated with stigmatizing language in this setting remain poorly characterized.

OBJECTIVE

This study aimed to determine whether specific demographic factors and clinical outcomes are associated with the presence of stigmatizing language by physicians in the clinical documentation of encounters with opioid-related ICD-10 (International Statistical Classification of Diseases, Tenth Revision) codes.

METHODS

Hospital encounters with one or more associated opioid-related ICD-10 admission diagnoses on the hospital medicine service during the 2020 calendar year were analyzed for the presence of stigmatizing language in history and physical and discharge summaries. Multivariable adjusted logistic regression models were used to determine associations of age, race, gender, medication for addiction treatment use, against medical advice discharge, homelessness, comorbid polysubstance use, comorbid psychiatric disorder, comorbid chronic pain, cost, and 30-day readmission with the presence of stigmatizing language.

RESULTS

A total of 221 encounters were identified, of which 64 (29%) encounters had stigmatizing language present in physician documentation. Most stigmatizing language was due to use of “substance abuse” rather than the preferred term “substance use” (63/66 instances). Polysubstance use and homelessness were independently associated with the presence of stigmatizing language (adjusted odds ratio [aOR] 7.83; 95% CI 3.42-19.24 and aOR 2.44; 95% CI 1.03-5.90) when controlling for chronic pain and other covariates.

CONCLUSIONS

Among hospital medicine encounters with an opioid-related diagnosis, stigmatizing language by physicians in clinical documentation was common and independently associated with comorbid polysubstance use and homelessness.
Effects of ICT-based cognitive behavioral therapy using Smart Sleep for insomnia in older adults: Randomized controlled trial (Preprint)
Authors: Lee Yeonhee , Kim ChanHee , Kang Seung-Gul , Lee Seon-Heui
Published: October 2024

BACKGROUND

Insomnia is a common sleep disorder, especially among the elderly, with a significant impact on the quality of life (QoL) and is associated with various comorbidities. Traditional pharmacotherapy for insomnia is often unsuitable for older adults because of potential drug interactions and side effects, making non-pharmacological interventions such as cognitive behavioral therapy for insomnia (CBT-I) more appropriate. However, delivering CBT-I in a traditional face-to-face setting poses challenges including accessibility and adherence, particularly for older adults.

OBJECTIVE

This study aimed to evaluate the effectiveness of an information and communication technology (ICT)-based CBT-I program, “Smart Sleep,” specifically designed to improve insomnia among community-dwelling elderly persons.

METHODS

A randomized, single-blind controlled trial was conducted with 59 elderly participants from Incheon, South Korea. Participants were divided into an intervention group, which used the Smart Sleep mobile app, and a control group. The intervention group received 8 weeks of non-face-to-face CBT-I through the application, which included sleep diaries, relaxation exercises, and real-time consultations. Outcomes were measured at baseline, week 4, and week 8, with a focus on insomnia severity, sleep quality, sleep efficiency, dysfunctional beliefs about sleep, depression, and QoL.

RESULTS

The intervention group showed significant improvements in insomnia severity, sleep quality, sleep efficiency, and dysfunctional beliefs about sleep compared with the control group. However, there was no significant difference in the QoL between the two groups (F=0.998, p=.372). Participation rates in the Smart Sleep program were high, with a 94% completion rate for sleep diary tasks and 100% participation in real-time consultations.

CONCLUSIONS

The ICT-based CBT-I program "Smart Sleep" effectively improved sleep-related outcomes among elderly participants, demonstrating the potential of non-face-to-face interventions in managing insomnia in this population. The program is user-friendly, and ICT-based coaching contributed to high engagement. To ensure broader access for the elderly, distribution through community welfare or public health centers is recommended.

CLINICALTRIAL

cris.org KCT0007287
The Place of Gladue in Constitutional Law
Authors: Kerr Lisa
Published: October 2024

While the Supreme Court of Canada has been a strong defender of the Gladue sentencing framework that it constructed under section 718.2(e) of the Criminal Code, the Court has so far declined to hold directly that the Gladue approach is constitutionally required. A majority decision in Sharma rejected one possible path to the constitutionalization of Gladue by way of section 15 of the Charter. But the Gladue principles have had a significant impact on the section 12 context, where the integration of Gladue into section 12 jurisprudence reveals much about how Gladue works in the everyday world of sentencing courts. Gladue fits well with section 12 because both protect and tolerate a highly discretionary system of sentencing law in which trial judges must be substantially free to respond to the mix of factors before them. In this system, Gladue functions as an epistemic demand but not as an exceptional law of sentencing for Indigenous people. While the Court has repeated that section 718.2(e) is aimed at reducing overrepresentation of Indigenous people in prison, it is simultaneously clear that judges must apply the universal, fundamental principle of proportionality when imposing sentences on Indigenous people. On two specific topics explored in this paper — the impact of imprisonment and the use of personal traits in reasonable hypotheticals — the Gladue approach has become highly consequential to the question of gross disproportionality under section 12 and, more generally, to the viability of mandatory minimums.
Legislative Context in Sentencing: A Closer Look at R v Sharma
Authors: Mancini Mark
Published: October 2024

This short paper argues that the Sharma majority’s methodological clarification vis-a-vis section 15 is consistent with how courts understand legislative design choices in Canadian law and is a necessary first step to understanding the legal effect of an impugned law. Properly understood, the clarification should not lead to a problem of double deference. Rather, it is an encapsulation of an age-old idea: that “it is the most natural and genuine exposition of a statute to construe one part of the statute by another part of the same statute, for that best expresseth the meaning of the makers.”
A Study of Fang Huawen’s Chinese Version of Rebecca from the Perspective of Skopos Theory
Authors: Li Wenzhe
Published: October 2024

This paper analyzes Fang Huawen’s Chinese version of Rebecca from the perspective of Skopos Theory. By obtaining the different descriptions in the novel, such as linguistic description, mental description, and environmental description, the essay focuses on discovering how the translator uses Skopos Theory during his translation. Through the analysis, the thesis finds out that Fang’s version combines the features of the original texts and the expression habit in Chinese, which fully demonstrates the original texts. The language of Fang’s version is brief and clear, and the content is coherent, meanwhile, this translation showcases the message from the original text to a great extent. Through studying Fang’s version, the thesis analyzes the translation strategies comprehensively by using the principle of fidelity, conference and skopos. Based on the above three principles, translators can adopt a variety of translation strategies, including domestication, foreignization, addition and subtraction, to translate high-quality translations to meet the needs of readers and disseminate the culture of other countries.
Automated Anemia Screening via Nail Image Analysis Using Fast RCNN
Authors: Aparna Ms. Kadhunoori
Published: October 2024

In the modern world, the health sector is quickly moving to digital platforms due to its practicality, ease of use, and affordability. According to the World Health Organization, anemia will continue to be a major global health issue in 2023, affecting 571 million women and 269 million young children. Anemia is still very common, especially in low- and middle-income countries. Photo plethysmography (PPG), a non-invasive technique for detecting anemia, has focused on selecting the appropriate light sources and wavelengths. Numerous methods, including data processing, photo detector design, and the use of lights with different spectra, can be used to detect anemia. Cost and excessive power use are the primary disadvantages. The proposed method includes a novel nail image-based anemia diagnosis approach to address the aforementioned issues. In order to detect leukonychia, which is characterized by the presence of white spots or streaks that are indicative of iron deficiency anemia, the primary goal is to suggest an improved method for analysing pictures of a person's nails. For example, this method makes use of state-of-the-art convolutional neural network architectures, such as Fast RCNN and RCNN. We show that Fast RCNN outperforms RCNN in terms of accuracy, reaching 92%. A significant step in the right direction toward enhancing anemia-related healthcare outcomes worldwide is the suggested strategy, which blends state-of-the-art technology with medical diagnostics. Additionally, the system creates opportunities for further improvements, such as adding real-time monitoring features and growing dataset which include a wider range of demographic traits.
La perspicacia de los derechos fundamentales para los refugiados: un estudio de Brasil y Uruguay
Authors: Menezes Santiago Marina Gabriela , Costa Souza Nilson
Published: October 2024

Brasil y Uruguay son países con tradición histórica en la acogida de refugiados, especialmente aquellos que son víctimas de conflictos armados en el mundo y, por las regiones continentales cercanas, aquellos que se ven obligados a abandonar sus países debido a crisis políticas y financieras. Con estas premisas, el presente trabajo académico abordará el panorama de los derechos fundamentales de los refugiados, destacando la legislación de Brasil y Uruguay, y explorando los desarrollos específicos relacionados con nuevas cuestiones de protección de vulnerabilidades de género y sexualidad, así como cuestiones colectivas, como los impactos irreversibles causados por el cambio climático. Finalmente, se pretende demostrar la posibilidad de adoptar nuevos criterios técnicos y legislativos y medidas para fortalecer la protección de los refugiados, destacando la importancia de implementar políticas públicas que abarquen a un mayor número de necesitados y actualicen los conceptos e instrumentos jurídicos que aborden las nuevas dificultades del escenario.
The Effectiveness and Safety of Danggui Buxue Decoction for Iron Deficiency Anemia: A Systematic Review and Meta-Analysis
Authors: Kim Chae-eun , Kim Mikyung , Sun Seung-ho
Published: October 2024

Objectives: This study was aimed at evaluating the effectiveness and safety of Danggui buxue decoction (DBD) for iron deficiency anemia (IDA) by systematic review and meta-analysis of the randomized controlled trials (RCTs).Methods: Randomized controlled trials on the treatment of DBD for IDA patients were selected from among the literature published from the beginning of each database to May 30, 2023 in nine domestic and foreign databases (PubMed, EMBASE, Cochrane, Chinese Academic Journals (CAJ), CiNii Research, J-STAGE, Oriental Medicine Advanced Searching Integrated System (OASIS), Research Information Sharing Service (RISS), and ScienceON). The quality of the literature was evaluated using the Cochrane ROB tool 2.0 (ROB2) and GRADE method. The meta-analysis was conducted using RevMan5.4.Results: A total of 636 patients with IDA were finally selected from the 7 RCTs. The meta-analysis showed that the treatment groups that underwent both DBD and conventional treatment were statistically higher than the control groups that performed only conventional treatment in all indicators that showed effectiveness of DBD such as red blood cell (mean difference (MD) 0.38×10 12/L, 95% CI: 0.16-0.60), hemoglobin (MD 12.45 g/L, 95% CI: 10.27-14.63), serum ferritin (MD 3.50 μg/L, 95% CI: 1.71-5.29), and total effective rate (relative risk (RR) 1.13, 95% CI: 1.05-1.21). The incidence of adverse events was 0.39 times lower in the DBD group than in the conventional group (RR 0.39, 95% CI: 0.22-0.70).Conclusion: This study demonstrated the effectiveness and safety of DBD with conventional treatment and further provided a basis for administering DBD to patients with IDA in clinical treatment.
A Study on the Relationship between Allergic Diseases and Gastrointestinal Discomfort Symptoms: Using Propensity Score Matching
Authors: Kim Young-Eun , Park Jeong Hwan , Jun Hyeong Joon , Lee Sanghun
Published: October 2024

Objectives: This study aimed to investigate the relationship between allergic diseases and digestive discomfort symptoms using a dataset for the traditional Korean medicine examination.Methods: The study included 389 subjects in the allergy group, diagnosed with allergic diseases by either a Korean medicine doctor or modern medical doctor, and there were 4,160 subjects in the control group. Propensity score matching was used to control the factors affecting the allergic disease and digestive discomfort symptoms. These factors included age, sex, medication history, obesity, smoking status, alcohol consumption, meal frequency, meal quantity, eating speed, sleep quality, stress level, and physical activity, matched at a ratio of 1:1. Logistic regression was used to estimate the adjusted odds ratio of digestive discomfort symptoms in the allergy group compared to the control group.Results: Compared to the control group, subjects in the allergy group had a significantly higher risk of having abdominal distention 1.62 times (OR=1.62, 95% CI: 1.13-2.32, p-value=0.008) and postprandial fatigue 1.41 times (OR=1.41, 95% CI: 1.02-1.95, p-value=0.037).Conclusion: The study suggests that allergic diseases were associated with certain digestive discomfort symptoms. The findings of this study can serve as a basis for managing both allergic diseases and digestive discomfort symptoms together.
A Scoping Review on the Safety of Yeongji (Ganoderma lucidum)
Authors: Lee Seyeon , Yoon Hansung , Kim Haeun , Ku Kibeom , Kim Mariah , Nam Irang , Han Changwoo
Published: October 2024

Purpose: A scoping review was conducted to assess the toxicity and safety of Ganoderma lucidum.Methods: A literature search was conducted in several medical databases (EMBASE, Scopus, PubMed, Cochrane Library, ScieneON, and RISS) to identify studies related to G. lucidum. We extracted clinical manifestations of adverse events described in the included studies and analyzed whether the incidence of each adverse event was higher in the G. lucidum group compared to the placebo group.Results: An initial search yielded 1,409 studies, of which 31 studies met the criteria and included in the final analysis (7 randomized controlled trials, 5 nonrandomized studies, and 19 case reports). Several gastrointestinal, respiratory, neurological, and dermatological manifestations were reported as adverse events in the included literature. However, no serious adverse events with a causal relationship to G. lucidum were reported in studies other than case reports, and no statistically significant differences in the incidence of any adverse events were observed between the G. lucidum group and the placebo group (p>0.05).Conclusion: Our findings do not seem to support the claim that G. lucidum poses a safety risk when consumed as food or as an ingredient in food. However, given the existence of some adverse events where a causal link to G. lucidum cannot be entirely ruled out, further research and ongoing monitoring are still warranted.
The Effect of Combination Therapy of Saengmaek-san Decoction and Western Medicine on Heart Failure: A Systemic Review and Meta-Analysis
Authors: Kim Seo-hyun , Kang Ji-hyeon , Kim Chae-eun , Won Hee-ju , Jang Woo-seok
Published: October 2024

Objectives: This study was conducted to evaluate the effectiveness of the combination therapy of Saengmaek-san decoction and Western medicine on heart failure.Methods: A search was conducted on June 22, 2024 using keywords such as “heart failure”, “saengmaeksan”, and “shengmaisan”. A meta-analysis was conducted according to the outcome measurements such as the total effective rate (TER), serum B-type natriuretic peptide (BNP), echocardiography results (left ventricular ejection fraction (LVEF), left ventricular end-diastolic diameter (LVEDD), left ventricular end-systolic diameter (LVESD), stroke volume (SV)), and six-minute walk test (6MWT). Data analysis was performed using the RevMan 5.4.1 software, and Cochrane’s risk of bias (ROB) was used to assess the quality of the papers.Results: A total of eight randomized control trials were selected. The treatment group combining Saengmaek-sann and Western medicine showed significant improvement effects in terms of TER, BNP, LVEF, LVESD, LVEDD, SV, and 6MWT compared to the control group using Western medicine alone [TER] RR=1.23, 95% CI: 1.13–1.34, p<0.00001; [BNP] MD= -206.14, 95% CI : -257.49–-154.79, p<0.00001; [LVEF] MD=6.40, 95% CI : 5.54–7.27, p<0.00001; [LVEDD] MD=-6.55, 95% CI : -7.24–-5.85, p<0.00001; [LVESD] MD=-3.07, 95% CI: -3.92–-2.22, p<0.00001; [SV] MD=7.12, 95% CI : 5.73–8.50, p<0.00001; [6MWT] MD=43.69, 95% CI : 31.55–55.84, p<0.00001.Conclusion: This study suggests that the combination therapy of Saengmaek-san decoction and Western medicine is effective in treating heart failure. However, these findings should be interpreted cautiously due to the unknown or high risk of bias in the included trials.
A Case Report of Chronic Migraine Lasting 30 Years and Treated with Acupuncture
Authors: Kim Haeun , Nam Irang , Kim Mariah , Ku Kibeom , Lee Seyeon , Kwon Jungnam , Lee In , Choi Junyong , Yun Youngju , Kim Soyeon , Han Changwoo , Park Sojung , Hong Jinwoo
Published: October 2024

Objectives: The purpose of this study was to report the effectiveness of Korean medicine in the treatment of chronic migraine persisting for 30 years. This patient had been taking various painkillers (acetaminophen, nonsteroidal anti-inflammatory drugs, caffeine hydrate, etc.) every day for 30 years.Methods: The patient with chronic migraine was treated with acupuncture. Acupuncture treatment was performed on the gall bladder meridian (足少陽膽經) and bladder meridian (足太陽膀胱經) line passing through 24 of the 31 injection sites used for chronic migraine prevention treatment with botulinum toxin type A. The severity of the symptom was assessed by the daily Numerical Rating Scale (NRS) score of pain.Results: The patient received outpatient treatment 42 times and received only acupuncture treatment each time. The patient said that after 4 sessions of acupuncture treatment, the severity of pain was reduced from NRS 7 to NRS 5 and that the frequency and duration of the symptoms were lower. After 8 sessions of acupuncture treatment, the symptoms were reduced to NRS 3 and, after 14 days of treatment, to 0~1. Now she barely has any severe headaches.Conclusion: The findings of this study suggest that treatment with Korean medicine can be an effective option in treating chronic migraine. In addition, acupuncture can be a good treatment method for chronic migraine that cannot be fundamentally controlled by Western pain relievers.
A Case Report of Chest Discomfort Accompanying Insomnia in a Taeeumin Improved with Korean Medicine Treatment Focused on Gami Cheongsim-tang
Authors: Heo Hye-min , Lee Kyeong-hwa , Heo Kyeong-hwa , Kwak Min-jae , Cho Seung-yeon , Park Seong-uk , Park Jung-mi , Ko Chang-nam
Published: October 2024

Objectives: The purpose of this study was to report the case of a patient with chest discomfort and insomnia.Methods: The patient in this case was hospitalized for 11 days and improved after the administration of Korean medicine, mainly Gami Cheongsim-tang. The Beck Anxiety Inventory and Beck Depression Inventory were taken, and the insomnia severity index was measured on the first day and last day of the hospitalization. The patient’s subjective discomfort level was also evaluated daily.Results: Chest discomfort was reduced, mental breakdown symptoms such as depression and anxiety were greatly improved, and the quality of sleep was also enhanced after the Korean medicine treatment.Conclusion: This study suggests that Korean medicine might be effective in chest discomfort with anxiety and sleep disorder in a patient exhibiting Taeeumin-type personality.
MENTAL HEALTH, RESILIENT COPING AND HOPE AMONG SAO PAULO RESIDENTS DURING COVID-19 SOCIAL DISTANCING
Authors: Pires Larissa Cavalcante , Santana William Ferraz de , Romano Fillipe Soares , Takayanagi João Francisco , Tavares Giselle Helena , Lusby Carolin , Uvinha Ricardo Ricci , Oliveira Nara Rejane Cruz de
Published: October 2024

The COVID-19 pandemic has globally impacted mental health. This study, conducted in Sao Paulo, investigated levels of anxiety, depression, resilient coping, and hope during the pandemic. The objective was to analyze the pandemic's effects on the mental health of São Paulo's population and explore coping strategies and hope. Data were collected among 1,434 adults between July 8 and August 8, 2020, using an online questionnaire that included sociodemographic data and scales to measure anxiety (Patient-Reported Outcomes Measurement Information System Adult (PROMIS®) Short Form v1.0-Anxiety 4a), depression (PROMIS® Short Form v1.0-depression 4a), resilient coping (4-item Brief Resilient Coping Scale), and hope (12-item Herth Hope Index). The results showed that being young, female, having suicidal thoughts, and adhering to quarantine policies were associated with higher levels of anxiety. Higher scores in resilient coping (-0.24) and hope (-0.06) correlated with lower anxiety. The data also revealed that being young, female, having suicidal thoughts, and living with elderly individuals increased depression scores. Conversely, higher scores in resilient coping (-0.35) and hope (-0.14) were related to lower levels of depression. These findings indicate that the pandemic significantly affected mental health in São Paulo. Resilient coping strategies and hope demonstrated potential to alleviate psychological distress, highlighting the importance of effective public mental health policies to address future crises. Therefore, investing in programs that promote resilience and hope may be crucial for mitigating adverse psychological impacts in emergency health situations.
ANÁLISE DA EFICIÊNCIA REPRODUTIVA DOS PROTOCOLOS HORMONAIS PRESYNCH E OVSYNCH EM VACAS HOLANDESAS
Authors: Rodrigues Fernando Miller Sousa , Nunes Victor Jordão Pimentel , Vieira Paulo Rufino Paulino
Published: October 2024

Reproductive efficiency depends on reducing the calving interval through artificial insemination or natural breeding, leading to a higher conception rate in a shorter time. The Presynch and Ovsynch insemination protocols are the most commonly used. The objective of this study was to evaluate which of the Presynch or Ovsynch protocols has greater reproductive efficiency for high-producing dairy cows, analyzing the results obtained from data collected through the database of Lenheiros farm, located in Carmo do Paranaíba-MG, using Ideagri software, focusing on inseminations evaluated from 2021 to 2022, and observing the pregnancy rate. The data were compiled and processed in Microsoft Excel® using descriptive statistics. There was no significant difference between the conception rates of the Ovsynch and Presynch protocols during dry and rainy periods. However, over the 12 months of study, it was observed that the Ovsynch protocol was effective in inseminating cows with late pregnancies, achieving a 67.1% conception rate, which increases the pregnancy rate on the property, as this method is applied only to cows that did not achieve positive results after synchronization. Thus, the final conclusion is that the Ovsynch protocol was effective in inseminating cows with late pregnancies, regardless of the climate.
Limitations for Quantum Algorithms to Solve Turbulent and Chaotic Systems
Authors: Lewis Dylan , Eidenbenz Stephan , Nadiga Balasubramanya , Subaşı Yiğit
Published: October 2024

We investigate the limitations of quantum computers for solving nonlinear dynamical systems. In particular, we tighten the worst-case bounds of the quantum Carleman linearisation (QCL) algorithm [Liu et al., PNAS 118, 2021] answering one of their open questions. We provide a further significant limitation for any quantum algorithm that aims to output a quantum state that approximates the normalized solution vector. Given a natural choice of coordinates for a dynamical system with one or more positive Lyapunov exponents and solutions that grow sub-exponentially, we prove that any such algorithm has complexity scaling at least exponentially in the integration time. As such, an efficient quantum algorithm for simulating chaotic systems or regimes is likely not possible.
Deterministic Bethe state preparation
Authors: Raveh David , Nepomechie Rafael I.
Published: October 2024

We present an explicit quantum circuit that prepares an arbitrary U(1)-eigenstate on a quantum computer, including the exact eigenstates of the spin-1/2XXZ quantum spin chain with either open or closed boundary conditions. The algorithm is deterministic, does not require ancillary qubits, and does not require QR decompositions. The circuit prepares such an L-qubit state with M down-spins using (LM)−1 multi-controlled rotation gates and 2M(L−M) CNOT-gates.
Structure and properties	of the welded joint during arc welding of low-carbon steel under a layer of flux obtained from metallurgical slag of electric steelmaking
Authors: Startsev E. A. , Grigoriev V. V. , Bakhmatov P. V.
Published: October 2024

The results of the study of the influence of the thermophysical properties of the welding flux obtained by processing man-made waste of electric steelmaking (metallurgical slag) on the structure and properties of welded butt joints of thin-sheet low-carbon steel, with automatic arc welding on ceramic linings, are presented. Welding modes have been established using the developed flux, contributing to the achievement of seam sizes according to GOST8713–79, C4 joints, compliance with the mechanical properties of joints close to the base metal and ensuring a minimum level of welding deformations and stresses.
Method for determining crack resistance of structural materials at quasi-brittle fracture after stable crack growth
Authors: Smirnov V. I. , Minkin A. I. , Margolin B. Z.
Published: October 2024

The cases in laboratory practice of experimental investigations of fracture toughness are considered, when as a result of the tests the determination characteristics of fracture toughness (KJC, JC, JR-curves, δR-curves) cannot be performed correctly in accordance with the requirements of existing standards. A simplified technique for constructing JR-curves has been developed, allowing in these cases to obtain the necessary characteristics of crack resistance (JR-curves, J1C, JC, δR-curves) and thereby significantly increase the information content of the tests carried out. Methodological recommendations on conducting tests and processing of their results are given. Approbation and verification of the proposed method have been carried out.
Study of electrical strength and electrical resistance of cast microwires in glass insulation
Authors: Bobkova T. I. , Vasiliev A. F. , Margolin V. I. , Serdyuk N. A. , Tupik V. A. , Farmakovsky B. V. , Khromenkov M. V.
Published: October 2024

The results of a comprehensive study of the electrical strength of glass insulation and the electrical resistance of cast microwires insulated with borosilicate glass in the temperature range from −60 to 155°C are presented.
Del documento en el derecho romano hacia las herramientas tecnológicas = From the document in roman law towards technological tools
Authors: Juárez Norma Alicia , Peralta Soledad Andrea
Published: October 2024

Para lograr el objetivo propuesto el trabajo se dividirá en dos partes. En la primera parte se analizará la forma en que se celebraban los actos jurídicos de la época arcaica, principalmente la  mancipatio, como el negocio per aes et libram más extendido en su uso; la stipulatio, como contrato verbal que deviene en contrato litteris, la aparición de las formas de testar que admitirán se grabe en tablillas la  voluntad del testador, principalmente, la mención del nombre del heredero instituido, la utilización de la marca del testador, sello y firma. La utilización cada vez más frecuente de la escritura y la aparición del encargado de efectuar ese trabajo, el tabelión y luego más modernamente la figura del notario, hacedor por excelencia del documento escriturario. Las disposiciones del Corpus Iuris Civilis consagrando la utilización del documento escrito. En la parte segunda, se analizará el fenómeno de la firma digital como resultado de los adelantos tecnológicos y los pasos previos que concluyen con la sanción de las leyes actuales sobre firma digital y documento electrónico y las disposiciones del Código Civil y Comercial de la Nación a ese respecto.
ABSTRACT: To achieve the objective, the work will be divided into two parts. In the first part, the way in which legal acts ere celebrated in the archaic era will be analyzed, mainly the mancipatio, as the most widespread business per aes et libram in its use; the stipulatio, as a verbal contract that becames a litteris contract, the appearance of the forms of will that wil allow the will of the testator to be recorded on tablets, mainly the mention of the mane of the instituted heir, the use of the testator´s mark, seal and signature. The increasingly frequent use of writing and the appearance of the person in charge of carrying out that work, the tabelion, and then more modernly the figure of the notary, maker par excellence of the written document. The provisions of the Corpus Iuris Civilis enshrining the use of the written document. In the second part, the phenomenon of the digital signature will be analyzed as a result of technological advances and the previous steps that conclude with the sanction of the current laws on digital signature and electronic document and the provisions of the Civil and Commercial Code of the Nation, that respect.