bluuebunny/crossref_metadata_2025 huggingface dataset:
Effects of Exercise and Sports Intervention and the Involvement Level on the Mineral Health of Different Bone Sites in the Leg, Hip, and Spine: A Systematic Review and Meta-Analysis
Authors: Oliveira Thiago P. , Espada Mário C. , Massini Danilo A. , Robalo Ricardo A. M. , Almeida Tiago A. F. , Hernández-Beltrán Víctor , Gamonales José M. , Castro Eliane A. , Pessôa Filho Dalton M.
Published: August 2023

The current study analysed whether the osteogenic stimuli of exercises and sports have an independent effect on bone mineral density (BMD). Studies with a design having two different cohorts were searched and selected to distinguish the effect due to long-term involvement (i.e., athletes vs. non-active young with good bone health) and due to the planning of intervention (i.e., pre- vs. post-training) with exercises and sports. Moreover, only studies investigating the bone sites with a body-weight support function (i.e., lower limb, hip, and spine regions) were reviewed, since the osteogenic effects have incongruous results. A meta-analysis was performed following the recommendations of PRISMA. Heterogeneity (I2) was determined by combining Cochran’s Q test with the Higgins test, with a significance level of α = 0.05. The studies reporting the effect of involvement in exercise and sports showed high heterogeneity for the lower limb, total hip, and spine (I2 = 90.200%, 93.334%, and 95.168%, respectively, with p < 0.01) and the effect size on sports modalities (Hedge’s g = 1.529, 1.652, and 0.417, respectively, with p < 0.05) ranging from moderate to high. In turn, the studies reporting the effect of the intervention planning showed that there was no heterogeneity for the lower limb (I2 = 0.000%, p = 0.999) and spine (I2 = 77.863%, p = 0.000); however, for the hip, it was moderate (I2 = 49.432%, p = 0.054), with a low effect between the pre- and post-training moments presented only for the hip and spine (Hedge’s g = 0.313 and 0.353, respectively, with p < 0.05). The current analysis supported the effect of involvement in exercise and sports by evidencing the effect of either weight-bearing or non-weight-bearing movements on BMD at the femoral, pelvic, and lumbar bones sites of the athletes when comparing to non-athletes or non-active peers with healthy bones. Moreover, the effect of different exercise and sports interventions highlighted the alterations in the BMD in the spine bone sites, mainly with long-term protocols (~12 months) planned with a stimulus with high muscle tension. Therefore, exercise and sport (mainly systematic long-term practice) have the potential to increase the BMD of bones with body-weight support beyond the healthy values reached during life phases of youth and adulthood.
A Multifunctional Polyethylene Glycol/Triethoxysilane-Modified Polyurethane Foam Dressing with High Absorbency and Antiadhesion Properties Promotes Diabetic Wound Healing
Authors: Chen Chiu-Fang , Chen Szu-Hsien , Chen Rong-Fu , Liu Keng-Fan , Kuo Yur-Ren , Wang Chih-Kuang , Lee Tzer-Min , Wang Yan-Hsiung
Published: August 2023

The delayed healing of chronic wounds, such as diabetic foot ulcers (DFUs), is a clinical problem. Few dressings can promote wound healing by satisfying the demands of chronic wound exudate management and tissue granulation. Therefore, the aim of this study was to prepare a high-absorption polyurethane (PU) foam dressing modified by polyethylene glycol (PEG) and triethoxysilane (APTES) to promote wound healing. PEG-modified (PUE) and PEG/APTES-modified (PUESi) dressings were prepared by self-foaming reactions. Gauze and PolyMem were used as controls. Next, Fourier transform-infrared spectroscopy, thermomechanical analyses, scanning electron microscopy and tensile strength, water absorption, anti-protein absorption, surface dryness and biocompatibility tests were performed for in vitro characterization. Wound healing effects were further investigated in nondiabetic (non-DM) and diabetes mellitus (DM) rat models. The PUE and PUESi groups exhibited better physicochemical properties than the gauze and PolyMem groups. Moreover, PUESi dressing showed better anti-adhesion properties and absorption capacity with deformation. Furthermore, the PUESi dressing shortened the inflammatory phase and enhanced collagen deposition in both the non-DM and DM animal models. To conclude, the PUESi dressing not only was fabricated with a simple and effective strategy but also enhanced wound healing via micronegative-pressure generation by its high absorption compacity with deformation.
Icariin Supplementation Suppresses the Markers of Ferroptosis and Attenuates the Progression of Nonalcoholic Steatohepatitis in Mice Fed a Methionine Choline-Deficient Diet
Authors: Choi Jiwon , Choi Hyewon , Chung Jayong
Published: August 2023

Icariin, a flavonoid abundant in the herb Epimedium, exhibits anti-ferroptotic activity. However, its impact on nonalcoholic steatohepatitis (NASH) development remains unclear. This study aimed to investigate the potential role of icariin in mitigating methionine choline-deficient (MCD) diet-induced NASH in C57BL/6J mice. The results showed that icariin treatment significantly reduced serum alanine aminotrasferase and aspartate aminotransferase activities while improving steatosis, inflammation, ballooning, and fibrosis in the liver tissues of mice fed the MCD diet. These improvements were accompanied by a substantial reduction in the hepatic iron contents and levels of malondialdehyde and 4-hydroxynonenal, as well as an increase in the activities of catalase and superoxide dismutase. Notably, icariin treatment suppressed the hepatic protein levels of ferroptosis markers such as acyl-CoA synthetase long-chain family member 4 and arachidonate 12-lipoxygenase, which were induced by the MCD diet. Furthermore, transmission electron microscopy confirmed the restoration of morphological changes in the mitochondria, a hallmark characteristic of ferroptosis, by icariin. Additionally, icariin treatment significantly increased the protein levels of Nrf2, a cystine/glutamate transporter (xCT), and glutathione peroxidase 4 (GPX4). In conclusion, our study suggests that icariin has the potential to attenuate NASH, possibly by suppressing ferroptosis via the Nrf2-xCT/GPX4 pathway.
ATAD3A: A Key Regulator of Mitochondria-Associated Diseases
Authors: Chen Liting , Li Yuchang , Zambidis Alexander , Papadopoulos Vassilios
Published: August 2023

Mitochondrial membrane protein ATAD3A is a member of the AAA-domain-containing ATPases superfamily. It is important for the maintenance of mitochondrial DNA, structure, and function. In recent years, an increasing number of ATAD3A mutations have been identified in patients with neurological symptoms. Many of these mutations disrupt mitochondrial structure, function, and dynamics and are lethal to patients at a young age. Here, we summarize the current understanding of the relationship between ATAD3A and mitochondria, including the interaction of ATAD3A with mitochondrial DNA and mitochondrial/ER proteins, the regulation of ATAD3A in cholesterol mitochondrial trafficking, and the effect of known ATAD3A mutations on mitochondrial function. In the current review, we revealed that the oligomerization and interaction of ATAD3A with other mitochondrial/ER proteins are vital for its various functions. Despite affecting different domains of the protein, nearly all documented mutations observed in ATAD3A exhibit either loss-of-function or dominant-negative effects, potentially leading to disruption in the dimerization of ATAD3A; autophagy; mitophagy; alteration in mitochondrial number, size, and cristae morphology; and diminished activity of mitochondrial respiratory chain complexes I, IV, and V. These findings imply that ATAD3A plays a critical role in mitochondrial dynamics, which can be readily perturbed by ATAD3A mutation variants.
A Brief Review on the Potential of Psychedelics for Treating Alzheimer’s Disease and Related Depression
Authors: Pilozzi Alexander , Foster Simmie , Mischoulon David , Fava Maurizio , Huang Xudong
Published: August 2023

Alzheimer’s disease (AD), the most common form of senile dementia, is poised to place an even greater societal and healthcare burden as the population ages. With few treatment options for the symptomatic relief of the disease and its unknown etiopathology, more research into AD is urgently needed. Psychedelic drugs target AD-related psychological pathology and symptoms such as depression. Using microdosing, psychedelic drugs may prove to help combat this devastating disease by eliciting psychiatric benefits via acting through various mechanisms of action such as serotonin and dopamine pathways. Herein, we review the studied benefits of a few psychedelic compounds that may show promise in treating AD and attenuating its related depressive symptoms. We used the listed keywords to search through PubMed for relevant preclinical, clinical research, and review articles. The putative mechanism of action (MOA) for psychedelics is that they act mainly as serotonin receptor agonists and induce potential beneficial effects for treating AD and related depression.
E-Selectin, ICAM-1, and ET-1 Biomarkers Address the Concern of the Challenging Diagnosis of Interstitial Lung Disease in Patients with Autoimmune Diseases
Authors: Pulito-Cueto Verónica , Remuzgo-Martínez Sara , Genre Fernanda , Atienza-Mateo Belén , Mora-Cuesta Víctor M. , Iturbe-Fernández David , Lera-Gómez Leticia , Mora-Gil María Sebastián , Portilla Virginia , Corrales Alfonso , Blanco Ricardo , Cifrián José M. , González-Gay Miguel A. , López-Mejías Raquel
Published: August 2023

Interstitial lung disease (ILD) constitutes the most critical comorbidity in autoimmune diseases (ADs) and its early diagnosis remains a challenge for clinicians. Accordingly, we evaluated whether E-selectin, ICAM-1, and ET-1, key molecules in endothelial damage, could be useful biomarkers for the detection of AD-ILD+. We recruited patients with rheumatoid arthritis (RA)-ILD+ (n = 21) and systemic sclerosis (SSc)-ILD+ (n = 21). We included comparison groups of patients: RA-ILD− (n = 25), SSc-ILD− (n = 20), and idiopathic pulmonary fibrosis (IPF) (n = 21). Serum levels of these proteins were determined by ELISA. E-selectin, ICAM-1, and ET-1 serum levels were increased in RA-ILD+ and IPF patients in comparison to RA-ILD− patients. Additionally, SSc-ILD+ and IPF patients exhibited higher ICAM-1 levels than those with SSc-ILD−. The ability of E-selectin, ICAM-1, and ET-1 to discriminate RA-ILD+ from RA-ILD− patients, and ICAM-1 to distinguish SSc-ILD+ from SSc-ILD− patients was confirmed using ROC curve analysis. Furthermore, elevated levels of ET-1 and E-selectin correlated with lung function decline in RA-ILD+ and SSc-ILD+ patients, respectively. In conclusion, our findings support the relevant role of E-selectin, ICAM-1, and ET-1 in RA-ILD+ patients as well as of ICAM-1 in SSc-ILD+ patients, constituting potential screening blood biomarkers of ILD in AD. Moreover, this study suggests ET-1 and E-selectin as possible indicators of worsening lung function in RA-ILD+ and SSc-ILD+ patients, respectively.
Probing the Interaction between Isoflucypram Fungicides and Human Serum Albumin: Multiple Spectroscopic and Molecular Modeling Investigations
Authors: Li Xiangshuai , Yan Xiaojing , Yang Daibin , Chen Shuning , Yuan Huizhu
Published: August 2023

To better understand the potential toxicity risks of isoflucypram in humans, The interaction between isoflucypram and HSA (human serum albumin) was studied through molecular docking, molecular dynamics simulations, ultraviolet–visible absorption, fluorescence, synchronous fluorescence, three-dimensional fluorescence, Fourier transform infrared spectroscopies, and circular dichroism spectroscopies. The interaction details were studied using the molecular docking method and molecular dynamics simulation method. The results revealed that the effect of isoflucypram on human serum albumin was mixed (static and dynamic) quenching. Additionally, we were able to obtain important information on the number of binding sites, binding constants, and binding distance. The interaction between isoflucypram and human serum albumin occurred mainly through hydrogen bonds and van der Waals forces. Spectroscopic results showed that isoflucypram caused conformational changes in HSA (human serum albumin), in which the α-helix was transformed into a β-turn, β-sheet, and random coil, causing the HSA structure to loosen. By providing new insights into the mechanism of binding between isoflucypram and human serum albumin, our study has important implications for assessing the potential toxicity risks associated with isoflucypram exposure.
Additive Manufacturing of an IH-Type Linac Structure from Stainless Steel and Pure Copper
Authors: Hähnel Hendrik , Ateş Adem , Dedić Benjamin , Ratzinger Ulrich
Published: August 2023

Additive manufacturing (AM) of metals has the potential to provide significant benefits for the construction of future particle accelerators. The combination of low cost manufacturing of complex geometries in combination with efficiency gains from improved linac design enabled by AM may be one way towards future cost-effective green accelerator facilities. As a proof of concept, we present a high-efficiency Zeff=280 MΩ/m, 433.632 MHz IH-DTL cavity based on an AM design. In this case, the complex internal drift tube structures with internal cooling channels have been produced from 1.4404 stainless steel and from pure copper using AM. The prototype cavity, as well as stainless steel AM parts have been electroplated with copper. We present results from successful vacuum tests, low level RF measurements of the cavity, as well as the status of preparations for high-power RF tests with a 30 kW pulsed power amplifier.
Performance Evaluation of Photonics-Based Coherent MIMO Radar Systems for Maritime Surveillance
Authors: Amir Malik Muhammad Haris , Maresca Salvatore , Pandey Gaurav , Malacarne Antonio , Bogoni Antonella , Scaffardi Mirco
Published: August 2023

Multiple-input multiple-output (MIMO) radars offer significant advantages over conventional standalone radars in terms of target detection and localization capabilities. However, to fully exploit their potential, such systems require excellent time and phase synchronization among the central unit and the radar heads. Only recently, thanks to microwave photonics (MWP) techniques, it has been possible to develop the first coherent MIMO radar demonstrators. In this paper, a simulation tool in MATLAB programming language is proposed to model coherent MIMO radars based on MWP techniques in maritime surveillance applications. Moreover, a novel approach for estimating the radar cross section of extended maritime targets is presented. The system performance in co-located and distributed MIMO configuration, as well as in single- and multi-band operations, is evaluated by means of relevant key performance indicators (KPIs). Simulations are carried out in two close-to-reality scenarios. In the first, a co-located MIMO radar is mounted on top of a patrolling vessel. In the second, a distributed MIMO radar is deployed inside a port. The proposed KPIs are analyzed in terms of both geometric and frequency diversities of the system, laying the foundations for general system optimization criteria valid in any given surveillance application.
Transapical Mitral Valve-in-Ring Replacement Using the Innovative System under 3-Dimensional Printing Guidance
Authors: Wang Yiwei , Mao Yu , Zhai Mengen , Ma Yanyan , Li Lanlan , Liu Yang , Yang Jian
Published: August 2023

Background: Transcatheter mitral valve-in-ring replacement (TMViR) is an emerging alternative for patients with recurrent mitral regurgitation (MR) after a prior failed annuloplasty ring. However, intraoperative common issues and complications remain to be addressed. Case summary: We describe the case of a 67-year-old male patient who underwent surgical mitral concomitant tricuspid annuloplasty repair 7 years ago who developed recurrent severe MR (New York Heart Association functional class IV). To avoid a high-risk surgical reoperation, we chose to perform a TMViR using an innovative dedicated device—the Mi-thos system—via a transapical approach. A patient-specific, 3-dimensional printed model was used to guide the procedure to avoid potential challenges. The procedure was performed successfully, and the patient exhibited symptomatic improvement. Conclusions: This case report highlights the first use of the innovative Mi-thos system in a TMViR procedure. The findings demonstrate the feasibility and safety of utilizing the Mi-thos system, guided by 3-dimensional printing technology, for patients who have experienced recurrent mitral regurgitation MR following a failed annuloplasty ring.
Echocardiographic Evaluation of Atrial Remodelling for the Prognosis of Maintaining Sinus Rhythm after Electrical Cardioversion in Patients with Atrial Fibrillation
Authors: Wałek Paweł , Roskal-Wałek Joanna , Dłubis Patryk , Wożakowska-Kapłon Beata
Published: August 2023

Atrial fibrillation (AF) is the most common atrial tachyarrhythmia. One of the methods of AF treatment is direct current cardioversion (DCCV), but in the long-term follow-up we observe quite a high percentage of AF recurrences after this procedure. In order to assess the prognosis of DCCV effectiveness, we use clinical, biochemical and echocardiographic parameters. The objective of this review is to systematise the current knowledge on echocardiographic measurements in patients with persistent AF used to assess the progress of remodelling of the atrial wall, which affects the likelihood of maintaining sinus rhythm after DCCV. In this article, echocardiographic parameters for the evaluation of remodelling of the atrial wall are divided into groups referring to structural, mechanical, and electrical remodelling, as well as parameters for the evaluation of left ventricular filling pressure. The article aims to draw attention to the clinical value of echocardiographic measurements, which is the selection of patients who will maintain sinus rhythm after DCCV in the long-term follow-up, which will allow to avoid unnecessary risks associated with the procedure and enable the selection of the appropriate treatment strategy.
Flood Insurance, Building Codes, and Public Adaptation: Implications for Airport Investment and Financial Constraints
Authors: Assab Abderrahim
Published: August 2023

This paper investigates the impact of flood management policies on airport investment and the resulting financial constraints. Specifically, it examines the effects of flood insurance, building codes, and public adaptation investment on the investment decisions of 100 United States airports located in flood-prone areas. The paper estimated the financial loss from extreme precipitations and flooding using novel data from the United States Federal Emergency Management Agency, and a differences-in-differences framework leveraging the introduction of the 2012 Biggert–Waters reform of the National Flood Insurance Program. The findings reveal that while flood insurance costs negatively influence overall airport investment, they do not significantly affect investment–cash sensitivity. On the other hand, the introduction of stricter building codes and public adaptation investment leads to increased cash usage for investment purposes, particularly among airports exposed to extreme precipitation and flood risks. Furthermore, the analysis suggests that the observed increase in financial constraints resulting from stricter building codes and public adaptation investment is likely driven by the asymmetry of information rather than the materiality of flood risk. In other words, public investment in flood risk reduction appears to signal to investors that the airport is exposed to flood risk, potentially leading to increased financial constraints. This finding highlights the importance of considering information asymmetry when assessing the impact of flood management policies on financial constraints. Understanding the underlying drivers of these effects is crucial for supporting resilient infrastructure development and informing effective decision-making in flood-prone areas.
Non-Grain Production of Cultivated Land in Hilly and Mountainous Areas at the Village Scale: A Case Study in Le’an Country, China
Authors: Zhang Zuo , Zheng Lin , Yu Dajie
Published: August 2023

Non-grain production of cultivated land (NGPCL) is an essential factor that affects food security and sustainable agricultural development. Due to the large population and limited land area present in China, cultivated land resources are more extensive and valuable in hilly and mountainous areas, though the expansion of NGPCL threatens food security and is detrimental to the sustainable use of cultivated land resources. To better understand the problem of NGPCL in hilly and mountainous areas, this paper initially classifies NGPCL into four distinct types, namely unplanted cultivated land (UCL), planted non-grain crops (PNGC), engineering recoverable (ENR), and immediately recoverable (IMR), based on their planting types and attributes. Subsequently, we analyzed the spatial patterns and differentiation characteristics of these NGPCL types in Le’an County at the village scale through exploratory spatial data analysis and studied their driving factors using the geographical detector model. The findings show that the NGPCL rate in Le’an County was 18.53%, with ENR occupying the largest area, followed by PNGC and UCL, while IMR had the smallest area. The spatial distribution of NGPCL in Le’an County suggests that there are correlations with all four types of NGPCL, which exhibit spatial clustering, except for IMR, which displays spatial heterogeneity. We attribute the phenomenon of NGPCL in Le’an County to natural, social, and economic factors, with the driving forces having varying degrees of influence. Specifically, slope, altitude, and cultivated land protection intensity play significant roles in the overall NGPCL. This paper is of crucial significance to the local agricultural management department’s efforts to prevent and control the non-grain production of cultivated land and the Chinese Government’s efforts to ensure food security.
Functional and Neural Correlates Associated with Conditioned Pain Modulation in Patients with Chronic Knee Osteoarthritis Pain: A Cross-Sectional Study
Authors: Simis Marcel , Pacheco-Barrios Kevin , Vasquez-Avila Karen , Rebello-Sanchez Ingrid , Parente Joao , Castelo-Branco Luis , Marduy Anna , de Melo Paulo S. , Imamura Marta , Battistella Linamara , Fregni Felipe
Published: August 2023

Background: In this study, we aimed to assess the factors that predict a dysfunctional conditioned pain modulation (CPM) in chronic knee OA. Methods: This is a cross-sectional analysis of patients with chronic knee OA from a prospective cohort study in Brazil (n = 85). We performed linear and logistic multivariate regression models using the purposeful selection approach to test the relationship between the CPM in both knees (average) as a dependent variable and demographics, clinical, and neurophysiological as independent variables. Results: A significant negative association between WOMAC pain scores and CPM (β: −0.13) was found. This association was modified by the subjects’ race, being stronger in the non-white subjects. In our logistic regression models, pain intensity indexed with the WOMAC pain scale remained a significant association with dichotomized CPM. Furthermore, a significant CPM association with balance, indexed with the Berg Balance score, was evidenced (β: 0.04). Neurophysiological variables showed a significant negative relationship with CPM, such as the relative power of delta oscillations in the frontal area (β: −3.11) and central area (β: −3.23). There was no significant relationship between CPM and the following domains: cognitive, emotion, sleep, opioid receptor polymorphisms, and intrinsic variables of OA disease. There was no association of CPM with TMS-indexed inhibitory markers. Conclusions: These results may indicate that less function of the pain descending inhibitory system in patients with OA is correlated with higher activity-related pain (WOMAC), less balance, and cortical plasticity especially with increased low-frequency (delta) brain oscillations. These associations seem modified by race.
Incidence, Risk Factors and Mortality Associated with Major Bleeding Events in Hospitalized COVID-19 Patients
Authors: Lucijanic Marko , Tjesic-Drinkovic Ida , Piskac Zivkovic Nevenka , Pastrovic Frane , Rob Zrinka , Bacevac Mersiha , Sedinic Lacko Martina , Dzambas Eleonora , Medic Barbara , Vukoja Ivan , Busic Iva , Grgurevic Ivica , Luksic Ivica , Barsic Bruno
Published: August 2023

Thromboprophylaxis is a mainstay of treatment of hospitalized COVID-19 patients, due to the high occurrence of thrombotic events. This increases the risk of bleeding. However, data on bleeding events and associated risk factors are scarce. Thus, we aimed to investigate the incidence, predictors and clinical outcomes associated with major bleeding in hospitalized COVID-19 patients. We retrospectively evaluated a cohort of 4014 consecutively hospitalized COVID-19 patients treated in a tertiary-level institution in the period 3/2020–3/2021. Bleeding of any kind was documented in 322 (8%) and major bleeding in 129 (3.2%) patients. A total of 129 (40.1%) bleeding events were present at the time of hospital admission, and 193 (59.9%) occurred during hospitalization. In the multivariate logistic regression analysis, intensive-care-unit treatment (adjusted odds ratio (aOR) 6.55; p < 0.001), atrial fibrillation (aOR 2.55; p = 0.029), higher white-blood-cell count (WBC) (aOR 1.03; p = 0.021), lower hemoglobin (aOR 0.97; p = 0.002) and history of bleeding (aOR 17.39; p < 0.001) were recognized as mutually independent predictors of major bleeding. Major bleeding was significantly associated with increased in-hospital mortality compared to non-major-bleeding patients (59.7% vs. 34.8%, p < 0.001), especially if occurring during hospitalization. Median time from major bleeding to death was 5 days. Bleeding events are frequent in hospitalized COVID-19 patients, with a significant proportion of patients presenting at the time of hospital admission, and others almost universally exposed to anticoagulant and corticosteroid therapies. Major bleeding is associated with high mortality, especially if occurring during hospitalization. The recognition of patients at risk and implementation of timely interventions are of high clinical importance.
Current and Future PET Imaging for Multiple Myeloma
Authors: Ishibashi Mariko , Takahashi Miwako , Yamaya Taiga , Imai Yoichi
Published: August 2023

Positron emission tomography (PET) is an imaging modality used for the noninvasive assessment of tumor staging and response to therapy. PET with 18F labeled fluorodeoxyglucose (18F-FDG PET) is widely used to assess the active and inactive lesions in patients with multiple myeloma (MM). Despite the availability of 18F-FDG PET for the management of MM, PET imaging is less sensitive than next-generation flow cytometry and sequencing. Therefore, the novel PET radiotracers 64Cu-LLP2A, 68Ga-pentixafor, and 89Zr-daratumumab have been developed to target the cell surface antigens of MM cells. Furthermore, recent studies attempted to visualize the tumor-infiltrating lymphocytes using PET imaging in patients with cancer to investigate their prognostic effect; however, these studies have not yet been performed in MM patients. This review summarizes the recent studies on PET with 18F-FDG and novel radiotracers for the detection of MM and the resulting preclinical research using MM mouse models and clinical studies. Novel PET technologies may be useful for developing therapeutic strategies for MM in the future.
Microstructure and Mechanical Properties of Low-Cost SiC-Reinforced Aluminum and Al4Cu Matrix Composites Produced by Sintering in Vacuum
Authors: Wąsik Anna , Leszczyńska-Madej Beata , Madej Marcin , Goły Marcin
Published: August 2023

Composite materials based on Al and Al4Cu with the addition of SiC particles (2.5; 5; 7.5; 10 wt.%) were produced in low-cost conventional powder metallurgy processes involving mixing, compacting with a pressure of 300 MPa, and sintering at 600 °C in a vacuum atmosphere. An attempt was made to create a relationship between the vacuum sintering and the microstructure and mechanical properties of Al/SiC composites. The strength of the matrix-reinforcing interface depends on the chemical composition of the components; therefore, the influence of 4 wt.% copper in the aluminum matrix was investigated. Comprehensive microstructural and mechanical properties (including Brinell hardness, compressive and flexural strength measurements) of the produced composites were measured. The addition of 2.5 wt.% SiC to the Al4Cu matrix improved the mechanical properties of the composites compared to the matrix. In the composite with the addition of 2.5 wt.% of SiC, while the addition of the reinforcement did not affect the hardness and compressive strength and caused a rapid decrease in the flexural strength compared to the aluminum matrix, the addition of Cu to the matrix of this composite improved hardness (from 25 to 49 HB), compressive strength (from 423 to 618 MPa), and flexural strength (from 52 to 355 MPa).
Photocatalytic Performance of Sol-Gel Prepared TiO2 Thin Films Annealed at Various Temperatures
Authors: He Lu , Zahn Dietrich R. T. , Madeira Teresa I.
Published: August 2023

Titanium dioxide (TiO2) in the form of thin films has attracted enormous attention for photocatalysis. It combines the fundamental properties of TiO2 as a large bandgap semiconductor with the advantage of thin films, making it competitive with TiO2 powders for recycling and maintenance in photocatalytic applications. There are many aspects affecting the photocatalytic performance of thin film structures, such as the nanocrystalline size, surface morphology, and phase composition. However, the quantification of each influencing aspect needs to be better studied and correlated. Here, we prepared a series of TiO2 thin films using a sol-gel process and spin-coated on p-type, (100)-oriented silicon substrates with a native oxide layer. The as-deposited TiO2 thin films were then annealed at different temperatures from 400 °C to 800 °C for 3 h in an ambient atmosphere. This sample synthesis provided systemic parameter variation regarding the aspects mentioned above. To characterize thin films, several techniques were used. Spectroscopic ellipsometry (SE) was employed for the investigation of the film thickness and the optical properties. The results revealed that an increasing annealing temperature reduced the film thickness with an increase in the refractive index. Atomic force microscopy (AFM) was utilized to examine the surface morphology, revealing an increased surface roughness and grain sizes. X-ray diffractometry (XRD) and UV-Raman spectroscopy were used to study the phase composition and crystallite size. The annealing process initially led to the formation of pure anatase, followed by a transformation from anatase to rutile as the annealing temperature increased. An overall enhancement in crystallinity was also observed. The photocatalytic properties of the thin films were tested using the photocatalytic decomposition of acetone gas in a home-built solid (photocatalyst)–gas (reactant) reactor. The composition of the gas mixture in the reaction chamber was monitored using in situ Fourier transform infrared spectroscopy. Finally, all of the structural and spectroscopic characteristics of the TiO2 thin films were quantified and correlated with their photocatalytic properties using a correlation matrix. This provided a good overview of which film properties affect the photocatalytic efficiency the most.
ROBOMINER: Development of a Highly Configurable and Modular Scaled-Down Prototype of a Mining Robot
Authors: Gomez Virgilio , Hernando Miguel , Aguado Esther , Sanz Ricardo , Rossi Claudio
Published: August 2023

Historically, mining operations have faced numerous challenges, including safety hazards, inefficiencies, and environmental concerns. However, recent advances in robotics, automation, and artificial intelligence have presented opportunities for the mining industry. The ROBOMINERS project, a Horizon 2020 European Union initiative, aims to revolutionize the mining ecosystem by implementing disruptive robotic concepts. One such concept is resilience, which involves enabling mining robots to reconfigure morphologically during operation. This article presents the development of a modular robotic system that focuses on modularity and self-assembly to provide insight into developing a highly adaptable and compact solution for future mining robots. The robotic system is composed of a set of highly configurable modular robotic platforms that can be reconfigured with other robotic modules or submodules to form more complex systems to perform different tasks. Several module configurations are presented, and different locomotion experiments were carried out to test the ability of the modules to navigate unstructured environments. The modules exhibited great maneuverability in unstructured terrain and demonstrated self-assembly and reconfiguration capabilities during operation. This is a foundational step towards the long-term goal of developing compact autonomous agents capable of self-assembly and mining task execution.
Detection of Secondary Microplastics in an Aquatic Mesocosm by Means of Object-Based Image Analysis
Authors: Carmona-Valdivieso Dahlia E. , Valdivieso Tizziana , Carmona-Galindo Víctor D.
Published: August 2023

When plastics are discarded, they do not biodegrade and instead break down over time into progressively smaller particles, termed secondary microplastics, which adversely impact biota and human health as well as persist in the environment for centuries. Our research objective was to evaluate the capabilities of object-based image analyses in detecting compositionally varied microplastics suspended in an aquatic mesocosm under no-slip and turbulent water conditions. We found that the presence of polypropylene, polyethylene terephthalate, and low-density polyethylene microplastic pollution in both single-type and mixed-type suspensions was not detectable by either average red (R), average blue (B), average green (G), or average RBG pixel intensities, but was significantly detectable by means of total RBG pixel intensity from digital imagery of the surface-water. Our findings suggest that object-based image analyses of surface waters to quantify pixel information is better suited for monitoring the presence and absence of suspended microplastics, rather than for the stepwise determination of microplastic concentrations. We propose the development of a smartphone application to facilitate citizen-science monitoring of microplastic contamination as well as comment on future applications utilizing drone imagery to boost cloud-based mapping spatiotemporal plumes.
The Effects of Cellular Membrane Damage on the Long-Term Storage and Adhesion of Probiotic Bacteria in Caco-2 Cell Line
Authors: Kiepś Jakub , Juzwa Wojciech , Olejnik Anna , Sip Anna , Tomaszewska-Gras Jolanta , Dembczyński Radosław
Published: August 2023

Adhesion is one of the main factors responsible for the probiotic properties of bacteria in the human gut. Membrane proteins affected by cellular damage are one of the key aspects determining adhesion. Fluid-bed-dried preparations containing probiotic bacteria were analyzed in terms of their stability (temperature of glass transition) and shelf life in different conditions (modified atmosphere, refrigeration). Imaging flow cytometry was utilized to determine four subpopulations of cells based on their physiological and morphological properties. Lastly, adhesion was measured in bacteria cultured in optimal conditions and treated with heat shock. The results show that the subpopulations with no or low levels of cell membrane damage exhibit the ability to adhere to Caco-2 cells. The temperature of protein denaturation in bacteria was recorded as being between 65 °C and 70 °C. The highest glass transition temperature (Tg) value for hydroxypropyl methylcellulose (used as a coating substance) was measured at 152.6 °C. Drying and coating can be utilized as a sufficient treatment, allowing a long shelf-life (up to 12 months). It is, however, worth noting that technological processing, especially with high temperatures, may decrease the probiotic value of the preparation by damaging the bacterial cells.
Transcriptomic Analysis of Human Skeletal Muscle in Response to Aerobic Exercise and Protein Intake
Authors: Zeng Xueqing , Li Linghong , Xia Zhilin , Zou Lianhong , Kwok Timothy , Su Yi
Published: August 2023

This study aimed to provide a more comprehensive molecular insight into the effects of aerobic exercise (AE), protein intake (PI), and AE combined with PI on human skeletal muscle by comparing their transcriptomic profiles. Fourteen published datasets obtained from the Gene Expression Omnibus (GEO) database were used. The hub genes were identified in response to acute AE (ACTB, IL6), training AE (UBB, COL1A1), PI (EZH2), acute AE combined with PI (DDIT3), and training AE combined with PI (MYC). Both FOS and MYC were upregulated in response to acute AE, and they were, respectively, downregulated by higher PI and a combination of AE and PI. COL1A1 was upregulated by training AE but was downregulated by higher PI. Results from the gene set enrichment analysis (p < 0.05 and FDR < 25%) showed that AE and PI delivered their impacts on human skeletal muscle in analogous pathways, including aerobic respiration, mitochondrial complexes, extracellular matrix (ECM) remodeling, metabolic process, and immune/inflammatory responses, whereas, PI may attenuate the response of immune/inflammation and ECM remodeling which would be promoted by AE, irrespective of its types. Compared to PI alone, acute AE combined with PI would further promote protein turnover and synthesis, but suppress skeletal muscle contraction and movement.
Associations of Dietary Intake and Nutrient Status with Micronutrient and Lipid Composition in Breast Milk of Donor Women
Authors: Ureta-Velasco Noelia , Montealegre-Pomar Adriana , Keller Kristin , Escuder-Vieco Diana , Fontecha Javier , Calvo María V. , Megino-Tello Javier , Serrano José C. E. , García-Lara Nadia Raquel , Pallás-Alonso Carmen R.
Published: August 2023

The influence of the diet and nutritional status of milk donors on the nutritional composition of donor human milk (DHM) is unknown. The present study aimed to determine the nutritional profile of DHM and the associations between donors’ dietary intake and nutritional status and the micronutrient and lipid composition in DHM. For this purpose, 113 donors completed a food frequency questionnaire, provided a five-day weighed dietary record, and collected milk for five consecutive days. Nutrient determinations in donors’ erythrocytes, plasma, urine, and milk were performed. Multiple linear regressions were conducted for the evaluation of the associations. We highlight the following results: DHM docosahexaenoic acid (DHA) was positively associated with donors’ plasma DHA content and donors’ DHA intake (R2 0.45, p < 0.001). For every 1 g/day DHA intake, an increase of 0.38% in DHA content and 0.78% in total omega-3 content was observed in DHM (R2 0.29, p < 0.001). DHM saturated fatty acids were positively associated with erythrocyte dimethyl acetals, plasma stearic acid, trans fatty acids intake, and breastfeeding duration and negatively associated with erythrocyte margaroleic acid (R2 0.34, p < 0.01). DHM cholecalciferol was associated with plasma cholecalciferol levels and dairy intake (R2 0.57, p < 0.01). Other weaker associations were found for free thiamin, free riboflavin, pyridoxal, dehydroascorbic acid, and the lipid profile in DHM. In conclusion, the diet and nutritional status of donors influence the fatty acid profile and micronutrient content of DHM.
Development and Validation of Nutrition Literacy Assessment Instrument for Chinese Lactating Women: A Preliminary Study
Authors: Li Zhao , Zhou Yalin , Tan Yuwei , Zhu Xiaoyu , Liu Wei , Chen Yuhan , Qin Yong , Li Ruijun , Yu Lanlan , Zhao Runlong , Xu Yajun
Published: August 2023

This study focused on the development and validation of a nutrition literacy assessment instrument for Chinese lactating women (NLAI-L). A comprehensive literature review and group discussion by experts in relevant fields were adopted to determine the dimension, topics and questions of NLAI-L. Content validity was evaluated by a panel of experts. The exploratory factor analyses (EFA) and confirmatory factor analyses (CFA) were used to evaluate the construct validity. Cronbach’s α and split-half reliability were applied to examine the reliability of NLAI-L. The final NLAI-L consisted of 38 questions covering three dimensions: knowledge, behavior and skill. The EFA revealed four sub-domains for knowledge, one sub-domain for behavior and four sub-domains for skill. The results showed that NLAI-L had satisfactory content validity (CVI = 0.98, CVR = 0.96), good reliability (Cronbach’s α coefficient = 0.84) and acceptable construct validity (χ2/df = 2.28, GFI = 2.81, AGFI = 0.79, RMSEA = 0.057). In the application part, the average NL score was 46.0 ± 9.3. In multivariate linear regression, education level, age, postnatal period and occupation were the potential influencing factors of NL for Chinese lactating women. The study established an effective and reliable assessment instrument for Chinese lactating women (NLAI-L) through qualitative and quantitative methods. The establishment of NLAI-L will provide an effective tool for exploring the role of NL in health or disease and provide a basis for the formulation of targeted nutrition interventions.
Chemical Composition, Larvicidal and Molluscicidal Activity of Essential Oils of Six Guava Cultivars Grown in Vietnam
Authors: Luu Huynh Van Long , Nguyen Huy Hung , Satyal Prabodh , Vo Van Hoa , Ngo Gia Huy , Pham Van The , Setzer William N.
Published: August 2023

Diseases transmitted by mosquitoes and snails cause a large burden of disease in less developed countries, especially those with low-income levels. An approach to control vectors and intermediate hosts based on readily available essential oils, which are friendly to the environment and human health, may be an effective solution for disease control. Guava is a fruit tree grown on a large scale in many countries in the tropics, an area heavily affected by tropical diseases transmitted by mosquitoes and snails. Previous studies have reported that the extracted essential oils of guava cultivars have high yields, possess different chemotypes, and exhibit toxicity to different insect species. Therefore, this study was carried out with the aim of studying the chemical composition and pesticide activities of six cultivars of guava grown on a large scale in Vietnam. The essential oils were extracted by hydrodistillation using a Clevenger-type apparatus for 6 h. The components of the essential oils were determined using gas-chromatography–mass-spectrometry (GC-MS) analysis. Test methods for pesticide activities were performed in accordance with WHO guidelines and modifications. Essential oil samples from Vietnam fell into two composition-based clusters, one of (E)-β-caryophyllene and the other of limonene/(E)-β-caryophyllene. The essential oils PG03 and PG05 show promise as environmentally friendly pesticides when used to control Aedes mosquito larvae with values of 24 h LC50-aegypti of 0.96 and 0.40 µg/mL while 24 h LC50-albopictus of 0.50 and 0.42 µg/mL. These two essential oils showed selective toxicity against Aedes mosquito larvae and were safe against the non-target organism Anisops bouvieri. Other essential oils may be considered as molluscicides against Physa acuta (48 h LC50 of 4.10 to 5.00 µg/mL) and Indoplanorbis exustus (48 h LC50 of 3.85 to 7.71 µg/mL) and with less toxicity to A. bouvieri.
Utilizing Polyethylene Terephthalate PET in Concrete: A Review
Authors: Askar Mand Kamal , Al-Kamaki Yaman S. S. , Hassan Ali
Published: August 2023

In general, plastic waste has been growing remarkably. Numerous waste plastic products are generated by manufacturing processes, service industries, and municipal solid waste (MSW). The increase in plastic waste increases concern about the environment and how to dispose of the generated waste. Thus, recycling plastic waste becomes an alternative technique to the disposal of plastic waste in a limited landfill. One of the solutions is to use plastic waste as recycled material in concrete construction to produce what is called green concrete. This research illustrates a summary of studies that utilized polyethylene terephthalate (PET) in concrete as a volume ratio or concrete aggregate replacement. It presents data with regard to mixing design and concrete behavior when PET is used. Moreover, using PET in concrete industries may reduce environmental pollution such as the emission of carbon dioxide and plastic waste disposal problems.
Recycling of Nanocellulose from Polyester–Cotton Textile Waste for Modification of Film Composites
Authors: Srichola Preeyanuch , Witthayolankowit Kuntawit , Sukyai Prakit , Sampoompuang Chaiyaporn , Lobyam Keowpatch , Kampakun Prapakorn , Toomtong Raveewan
Published: August 2023

Textile waste has emerged as a critical global challenge, with improper disposal practices leading to adverse environmental consequences. In response to this pressing issue, there is growing interest in recycling textile waste containing cellulose as an alternative approach to reducing the impact of industrial waste on the environment. The objective of this research is to investigate the extraction and characterization of nanocellulose from polyester–cotton textile waste as a potential solution to address the growing concerns of waste management in the textile industry. To obtain nanocellulose, a comprehensive process involving alkaline sodium hydroxide (NaOH) treatment of the polyester–cotton textile (35% PET and 65% cotton) was employed, resulting in average yield percentages ranging from 62.14% to 71.21%. To achieve the complete hydrolysis of PET polyester in the blends, second hydrolysis was employed, and the optimized condition yield cotton fiber was 65.06 wt%, relatively close to the theoretical yield. Subsequently, the obtained cellulosic material underwent an acid hydrolysis process using 70 percent (v/v) sulfuric acid (H2SO4) solution at 45 °C for 90 min, resulting in nanocellulose. Centrifugation at 15,000 rpm for 15 min facilitated the separation of nanocellulose from the acid solution and yielded 56.26 wt% at optimized conditions. The characterization of the nanocellulose was carried out utilizing a comprehensive array of techniques, including absorption, transmission, and reflection spectra, and Fourier transform infrared. The characterization results provide valuable insights into the unique properties of nanocellulose extracted from textile waste. In this research, the obtained nanocellulose was mixed with PVA and silver nanoparticle to form biodegradable film composites as the reinforcement. In comparison, biodegradable film of PVA:nanocellulose 9.5:0.5 with silver nanoparticle 0.3 wt% and glycerol as a plasticizer exhibits better tensile strength (2.37 MPa) and elongation (214.26%) than the PVA film with normal cellulose. The prepared biodegradable film was homogeneous and had a smooth surface without the internal defect confirmed by the CT scan. This result opens avenues for enhancing the quantities of eco-friendly film composites, potentially replacing conventional plastic films in the future.