bluuebunny/crossref_metadata_2025 huggingface dataset:
Immunofluorescence v1
Authors: Hancock-Cerutti William , De Camilli Pietro
Published: April 2022

This protocol describes the fixation of cultured cells in paraformaldehyde solution and immunofluorescent labeling of mitochondria and DNA.
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Cell culture, transfection, and imaging v1
Authors: Hancock-Cerutti Will , De Camilli Pietro
Published: April 2022

This protocol describes general procedures for culturing HeLa cells, transient transfection, and imaging using an Andor Dragonfly spinning disk confocal system.
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Prescription patterns of somatostatin analogues in patients with acromegaly and neuroendocrine tumors v1
Authors: Machado Alba Jorge
Published: April 2022

Objective. Acromegaly and neuroendocrine tumors are rare diseases that, under certain conditions, can be treated with somatostatin analogues. The aim was to determine the prescription patterns of somatostatin analogues in a group of patients with acromegaly and neuroendocrine tumors affiliated with the Colombian Health System. Design. A retrospective study. Methods: A cohort of patients from a drug dispensing database that collected all prescriptions of long-acting somatostatin analogues (octreotide, lanreotide, pasireotide). Sociodemographic variables, clinical variables (diagnosis and comorbidities) and pharmacological therapy variables (dose, changes, persistence of use, comedications) were considered. Results: A total of 213 patients were identified, including 139 (65.3%) with acromegaly and 74 (34.7%) with neuroendocrine tumors. There was a predominance of women (58.7%) and a mean age of 59.7 ± 14.5 years. The most commonly used medications were lanreotide autogel (n = 107; 50.2%), octreotide LAR (n = 102; 47.9%) and pasireotide LAR (n = 4; 1.9%). During follow-up, 11.3% of patients experienced modifications of therapy, with a mean duration from the beginning of treatment to the change in medication of 25 ± 15.9 months. A total of 48.9% of the patients with acromegaly and 87.1% of individuals with neuroendocrine tumors received maximum approved doses of the drug. Conclusions: Patients with acromegaly and neuroendocrine tumors in Colombia are mainly women and are most frequently treated with lanreotide autogel for acromegaly and with octreotide LAR for neuroendocrine tumors. In addition, a high proportion are managed with maximum doses of long-acting somatostatin analogues.
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The lower bound of diameter of Alternating groups
Authors:   Taras Shevchenko National University of Kyiv, Olshevskyi M.
Published: April 2022

In this paper we consider a specific case of the diameter search problem for finite groups, thecase where the system of generators is fixed. This problem is well-known and can be formulated in the following way: find the diameter of a group over its system of generators. The diameter of the corresponding Cayley graph is the diameter of a group over its specific system of generators. The main object of the research is the alternating group with the system of generators consisting of cycles having length three and the form (1,2,k). This system of generators is a classical irreducible system of generators of the alternating group. It is introduced the property of even permutations to be balanced. We consider the set of balanced permutations and permutations close enough to balanced and find minimum decompositions of them over defined system of generators. The main result of the paper is the lower bound of the diameter of Alternating group over con-sidered system of generators. The estimation is achieved using minimal decompositions of balanced permutations.
Deterministic and stochastic methods combining while solving the problem of defectoscopy of an elastic rod
Authors:   Taras Shevchenko National University of Kyiv, Zrazhevsky G. M. , Zrazhevska V. F. ,   National Technical University of Ukraine “Igor Sikorsky Kyiv Polytechnic Institute”
Published: April 2022

The paper considers the problem of natural harmonic oscillations of an elastic rod with stress-free ends in the presence of one or a set of defects. Defects are modeled by the inhomogeneity of the Young's modulus. The location of the defects, their geometric size, which is considered small, and the change in elastic properties are the parameters of the defects. The analysis of natural frequency shifts caused by the defect of the rod is the subject of the study. The aim of the work is a mathematical substantiation for the construction of fast and stable algorithms for determining the defect parameters of elastic bodies by analyzing free oscillations. The paper uses and compares fundamentally different research methods. The first methods are classical mathematical methods of mechanics, applied to the analysis of deterministic systems and based on analytical studies combined with numerical implementation. In contrast, a composite machine learning meta-algorithm used in standard statistical classification and regression - Bootstrap-aggregated Regression Trees (BART) - is used to solve the inverse problem. When comparing the constructed algorithms, the statistical method Sampling was used, which allowed to quantify the accuracy and stability of the algorithms.
Lysosomal storage diseases. Mucopolysaccharidosis types IV, VI, and VII – Morquio, Maroto–Lamy and Sly syndrome
Authors: Gorbunova Victoria N. , Buchinskaia Natalia V.
Published: April 2022

The review is devoted to the clinical, biochemical, and molecular genetic characteristics of autosomal recessive mucopolysaccharidoses (MPS) types IV, VI, and VII. MPS IV type, or Morquios syndrome, is represented by 2 types A and B. The cause of the most frequent MPS IVA is hereditary deficiency of galactose-6-sulfatase, due to the presence of inactivating mutations in the GALNS gene. The pathogenetic basis of the disease is associated with excessive accumulation in lysosomes, mainly of cartilage tissue of keratan sulfate and chondroitin-6-sulfate. Main clinical manifestations of MPS IVA are dwarfism and progressive deformity of the spine, sternum, and knees. The milder MPS IVB is due to hereditary -galactosidase deficiency and is an allelic variant of GM1 gangliosidosis. The cause of MPS VI, or MarotoLamy syndrome, and MPS VII, or Sly syndrome, is hereditary deficiency of arylsulfatase B and -glucuronidase, respectively. The pathogenesis of these diseases is due to the excessive accumulation of dermatan sulfate and, in the second case, additionally, heparan sulfate. Patients with type VI and VII MPS have a Hurler-like phenotype, but in the first case, intellectual deficiency are usually absent, while in Sly syndrome, moderate mental retardation is observed. The possibility of neonatal screening and early diagnosis of these MPS in order to increase the effectiveness of their prevention and treatment is discussed. The importance of experimental models for studying the molecular basis of the pathogenesis of these severe hereditary diseases and the development of various therapeutic approaches, such as bone marrow transplantation, enzyme replacement therapy and substrate-reducing therapy, is emphasized. Descriptions of clinical cases of MPS IVA and VI types are presented.
Dynamics of resistance to antibiotics in nosocomial staphylococci from multidisciplinary hospital
Authors: Gladin Dmitry P. , Kozlova Nadezhda S. , Korolyuk Alexander M. , Barantsevich Natalia E. , Baranov Ilya A. , Khairullina Alina R. , Barantsevich Elena P.
Published: April 2022

Background. Staphylococci are still the leading causative agents of infections associated with healthcare, and the study of their antibiotic resistance is still relevant.

Aim. The research is aimed at study of antibiotic resistance of hospital strains of staphylococci in dynamics.

Materials and methods. Susceptibility to 16 antimicrobial agents was studied in 554 Staphylococcus strains, isolated from patients in a multidisciplinary medical centre. The method of serial microdilutions was used.

Results. Antibiotic-resistant strains prevailed (85.4%). Methicillin-resistance and multy-resistance were found to be more typical for coagulase-negative strains 75.2% and 74.1% respectively, than for Staphylococcus aureus 14.2% and 15.4% respectively. Methicillin-resistance and poly-resistance in S. aureus was found to decrease it was 11.1% and 12.8% in 20152016 (17.1% and 17.9% respectively in 20112012). On the contrary, methicillin-resistance in coagulase-negative staphylococci strains during the same period increased 1.5 times. Totally, methicillin-resistant strains composed a half of the isolates 48.7%. The studied Staphylococcus strains were susceptible to vancomycin, daptomycin, tigecycline. Resistance to linezolid and amikacin was 2.2% and 2.7% respectively. S. aureus strains were all susceptible to linezolid, fusidic acid, rifampicin, trimethoprim-sulfamethoxazole. Minimum inhibitory concentrations (MIC) of antibiotics for staphylococci varied in wide ranges from 0.06 to 128 mg/l. For S. aureus and S. epidermidis, the MIC50 and MIC90 of only five drugs (benzylpenicillin, tigecycline, vancomycin, linezolid, and daptomycin) were the same, while the MIC50 and MIC90 of most of the other studied drugs against S. epidermidis were significantly higher compared to S. aureus.

Conclusion. The variability of resistance of staphylococci to antimicrobial drugs in a multidisciplinary hospital confirms the need for continuous monitoring of their antibiotic resistance.
Vitamin D deficiency in young children. The realities of today
Authors: Sergeev Yurii S. , Arsentev Vadim G. , Shabalov Nikolai P. , Antsiferova Elena S.
Published: April 2022

The article presents a review of the literature on the clinical aspects of assessing vitamin D deficiency in young children by the concentration of 25(OH)D (hydroxycalciferol) in blood serum. The purpose of the review was to familiarize pediatric specialists with the real state of affairs in assessing the clinical significance of diagnosing vitamin D status, its relationship with the prevention of deficient rickets, ways of correcting and choosing the dose of calciferol. A daily dose of 400 IU of vitamin D for young children is effective and safe in preventing deficient rickets. Higher subsidized doses of calciferol have not been shown to be more effective. In addition, they can potentially lead to toxic levels of vitamin D metabolites in the blood. When using lower daily doses (less than 400 IU), an adequate prophylactic effect may not be achieved. Determination of the level of circulating serum hydroxycalciferol, which characterizes the status of vitamin D in the body, is not recommended for routine examination and as a standard for diagnosing deficient rickets in young children. Calciferol has multilateral effects, modulates not only phosphorus-calcium metabolism, but also affects other systems and functions of the body, in particular, ontogenesis and the immune system. According to foreign literature, all infants should receive vitamin D for the prevention of rickets, treatment from the age of one month. This is most reliably identified for children, probably at risk. Convincing data indicating a positive protective effect on diabetes mellitus D on unforeseen pathology, for example, the frequency of exclusion of pneumonia, infectious diarrhea, atopic dermatitis in infancy, has not yet been obtained.
Epidemiological and clinical and laboratory features of COVID-19 in pediatric patients
Authors: Belykh Natalya A. , Solovyova Olga A. , Anikeeva Natalya A.
Published: April 2022

The article presents up-to-date data on the main pathogenetic mechanisms and features of the new coronavirus infection caused by the SARS-CoV-2 virus. The review highlights the main epidemiological features of infection with SARS-CoV-2 in children at various age periods, features of the immune response and variants of the course of the disease with lung damage, as well as other organs and systems. The clinical and laboratory features of the course of a new coronavirus infection in children are highlighted. It was found that children are less likely to develop severe COVID-19 than adults. More than 95% of all cases of the disease range from asymptomatic course to clinical manifestations of mild and moderate severity. About 2% of childrens patients need hospitalization, including in the intensive care unit and ventilator. However, extrapulmonary manifestations are registered in children more often than in adults, especially from the gastrointestinal tract and circulatory organs. According to numerous authors, the features of the clinical and laboratory course of COVID-19 in pediatric patients are probably associated with a number of factors, among which age-related features of the immune response, the functioning of angiotensin-converting enzyme-2 (ACE-2) used by coronaviruses as a cellular receptor are indicated. Understanding the role of the child population in the dynamics of transmission of infection is important, since children significantly affect the rate of infection spread.
Combination of tuberculosis of the intra thoracic lymph nodes and acute lymphoblastic leukemia in a child
Authors: Lozovskaya Marina E. , Yarovaya Yulia A. , Vasilieva Elena B. , Klochkova Ludmila V. , Malysheva Elena A. , Noskova Olga M.
Published: April 2022

According to scientific research, malignant neoplasms in children are biomedical risk factors for the development of tuberculosis (TB). On the contrary, the occurrence of oncological disease in a child against the background of an existing tuberculous process is extremely rare. The combination of malignant neoplasm and tuberculosis creates difficulties in differential diagnosis, treatment of diseases, prevention of exacerbations and relapses. This article presents a clinical observation the development of acute lymphoblastic leukemia (ALL) in a 6-year-old child against the background of TB of the intrathoracic lymph nodes during treatment. TB proceeded favorably despite multiple family contact in the child and resistance of Mycobacterium tuberculosis to anti-tuberculosis drugs in adult relatives of the patient. At the onset of ALL, bilateral pulmonary infiltrates and pleural effusion were observed, which were not associated with TB. Specific polychemotherapy for ALL and continued chemotherapy for TB led to the cure of two diseases. Supportive cytostatic and immunosuppressive therapy for ALL required periodic courses of anti-relapse anti-tuberculosis therapy for 5 years. After 10 years of observation, the child is healthy. Thus, the possibility of a rare in clinical practice combination of TB and ALL in children should be taken into account in the diagnosis and treatment of these diseases. During courses of immunosuppressive therapy for ALL, there is a risk of reactivation of TB. It is necessary to recommend long-term observation of such children by a phthisiatrician and an oncologist to prevent recurrence of both diseases.
Structural epilepsy in children who have suffered a hemorrhagic stroke
Authors: Fomina Maria Yu. , Gumenik Helena V. , Korostovtsev Dmitry D. , Kovelenova Marina V.
Published: April 2022

The relevance of studying the consequences of hemorrhagic strokes in young children is due to the frequency of cerebrovascular pathology, the formation of persistent neurological deficits, including post-stroke epilepsy, and high mortality. It is known that hemorrhages are diagnosed in the first 28 days of life in 6-7 out of 100,000 infants, in children from the 28th day of life to 18 years of age from 0.7 to 5.1 cases per 100 thousand children. Mortality in hemorrhagic and ischemic strokes in children ranges from 7 to 28%. Epileptic seizures of the acute and acute period of stroke are prognostically unfavorable factors of the course of the disease. The article presents brief literature data on the etiology and localization of hemorrhagic strokes, their role in the formation of pharmacoresistant epilepsy. Special attention is paid to the role of late hemorrhagic disease of newborns, accompanied by intracranial hemorrhages, in the formation of structural epilepsy in the future. The paper describes own clinical observations of 25 patients suffering from epilepsy after a hemorrhagic stroke with a description of the clinical picture, features of paroxysmal states and their therapy, neuroimaging data, electroencephalographic phenomena. A clinical example is presented in which the clinical, anamnestic, electrophysiological data of a patient with pharmacoresistant epilepsy developed as a result of a hemorrhagic stroke on the background of late hemorrhagic disease of newborns are considered.

Structural epilepsy in children, formed after a hemorrhagic stroke, is accompanied by significant multi-regional damage, pronounced neurological deficit and is characterized by a pharmacoresistant course.
COVID-19 and the effect of its infodemic on people’s wellbeing
Authors: Taan Al Awar Dina H. , Abbas Mawaheb A. , Al Fehaidi Al Anoud S. , Zaghal Najwa Ali Al
Published: April 2022

In this research, it was used to look at social media behaviour during the pandemic and how it might have affected well-being. The WHO-5 Well-Being Index (WHO-5) score was used to do this. COVID-19-related material was sought for and disseminated through social media by those who participated in the study. This research shows how social media might affect people's well-being during this epidemic and other crisis in the future. 73 percent of the 993 participants were women, 91 percent were university graduates, and 50 percent worked in diverse occupations, with 20 percent working in health care. Participants said they got COVID-19-related news mostly via social media and messaging apps, with WhatsApp being the most popular. After authentication, the majority of participants said they shared information. Throughout the coronavirus pandemic, this research offers insight into the usage of Social Media and its influence on well-being. During catastrophes and disasters, social media behaviours may have an influence on public safety. There is also a need for global and local health authorities to better prepare for future challenges by developing policies and actions that address these difficulties. Social media activities may directly affect one's mental health, but more research is required before conclusions can be drawn.
Bipolar versus monopolar transurethral resection for benign prostatic hypertrophy: a prospective comparative study
Authors: P. Srinivasrao , Shashidhar Mallidu
Published: April 2022

Background: The transurethral resection of the prostate (TURP) is a well-known surgical procedure for treating benign prostatic hypertrophy in males. Monopolar TURP (MTURP) has been used in the past, however the morbidity associated with MTURP has led to the development of new surgical procedures. Energy is restricted between electrodes at the resectoscope site in bipolar TURP (BTURP), permitting the use of physiological irrigation medium. In terms of patient outcomes, there is still some doubt about the distinctions between various surgical procedures. This study aims to evaluate the efficacy of monopolar (M-TURP) and bipolar (B-TURP) TURP.Methods: In this prospective comparison trial, 100 patients were enrolled and table randomized to either M-TURP or B-TURP surgery for prostatic hyperplasia. Prostate size, post-void volume and hemoglobin were recorded pre and postoperatively. Resection time was noted.Results: Patients were divided into two groups, namely M-TURP and B-TURP. The mean age of patients was comparable between both groups. There is a significantly lower mean resection time in M-TURP compared to B-TURP. Drop-in hemoglobin levels (g/dl) in M-TURP patients were higher than in B-TURP. The M-TURP group showed a higher reduction in post-void residual volume than the B-TURP group. B-TURP group had a larger reduction in gland size than the M-TURP group.Conclusions: M-TURP and B-TURP are safe and effective procedures for treating BPH.
A cross sectional study on clinical profile and complications associated with diphtheria in Sir Ronald Ross Institute of Tropical and Communicable diseases, Hyderabad, Telangana state
Authors: Anjum Shabnam , Bhavani Kenche , Vijayasree L. , Krishna Ananda
Published: April 2022

Background: Diphtheria is a potentially fatal infection caused by Corynebacterium (C.) diphtheriae strains and occasionally by toxigenic C. ulcerans and C. pseudotuberculosis strains. Although effective vaccines are available all over the world, this disease has the potential to re-emerge. As there are few studies regarding clinical profile, complications, and immunization status among adult in Telangana, this study will bridge the gap in information regarding demographic data, clinical features, immunization status, and the presence of complications.Methods: Cross sectional study done for a period of 8 months from March-October 2019 at Sir Ronald Ross Institute of Tropical and Communicable Diseases, Hyderabad. Study was done on 150 diphtheria (clinical and microbiologically) positive cases admitted. The collected data was entered in Microsoft excel and analysed using Epi info v.7.2.6.6.Results: Out of the total study participants 34% belong to 10-14 years age group 99.3% had patch over tonsil, 98.7% had fever. Among the study participants, 19.3% had electrocardiography (ECG) abnormalities, 10.7% had breathing problems, 11.3% had both ECG abnormalities and breathing problems, 7.3% had diphtheria myocarditis. 20.7% were completely immunized and 46% were partially immunized, 6.6% patient’s immunization status were unknown and 26.7% of the patients were unvaccinated. The occurrence of complications was common among Muslims (p=0.001), rural residence (p=0.0005). Educational qualification was significantly associated with occurrence of complications (p=0.04), and people coming from lower socioeconomic strata had more complications compared to others (p≤0.05) Unvaccinated people suffered from more complications compared to vaccinated people (p=0.002).Conclusions: There is an age shift in the occurrence of diphtheria increasingly over 5 years of age.
Asymptomatic unilateral lateral semicircular canal aplasia associated with a dilated vestibule
Authors: Medeiros Nuno , Valente Pedro , Condé Artur , Larangeiro João
Published: April 2022

Lateral semicircular canal aplasia is a rare form of vestibular dysplasia. This is the last canal to be formed during the fetal period, becoming susceptible to isolated malformations. A 17-year-old male patient performed a magnetic resonance with a subsequent incidental finding of isolated, unilateral, lateral SCS aplasia associated with a dilated vestibule. He was asymptomatic and physical examination was unremarkable. Videonistagmography showed a diminished ipsilateral caloric response and ipsilateral v-HIT gains were normal. To the best of our knowledge, this is the first non-syndromic case of aplasia of the lateral SCS with no vestibular or audiological symptoms. This absence could be explained by compensation due to the congenital nature of this malformation.

 
El ejercicio ético en disputa: entre la enseñanza, el imperialismo y la reflexividad en el oficio antropológico
Authors: Quadrelli Sánchez Andrea
Published: April 2022

Se presenta un ejercicio ético referido a recorridos académicos e institucionales en la investigación antropológica y en la enseñanza, en un contexto político donde la dimensión de lo ético se construye a partir de normativas fiscalizadoras. Se destaca el valor de la práctica docente, articulando la participación de la investigadora en un seminario de ética y derechos humanos, de carácter obligatorio, de la licenciatura en Antropología de la Universidad de la República (Montevideo, Uruguay), con su experiencia en el proceso de evaluación del comité de ética de la Escola Nacional de Saúde Pública Sergio Arouca (Río de Janeiro, Brasil), que tuvo a cargo la revisión y aprobación de un proyecto de investigación doctoral. Este ejercicio ético encuentra expresiones singulares en los diferentes lugares en los que se inscriben nuestros procesos de investigación: en el campo, en contextos políticos propios y en la práctica docente, y retroalimenta todo el proceso de investigación, debate y análisis.
GENETIC IMPROVEMENT IN POPCORN
Authors: HARTMANN CARANHATO ANDRÉ LUÍS , ROMO TRINDADE RAFAEL WILLIAM , SANTOS UHDRE RENAN , JOSÉ BARTH PINTO RONALD , ALBERTO SCAPIM CARLOS , ZAGATTO PATERNIANI MARIA ELISA AYRES GUIDETTI
Published: April 2022

Popcorn consumption in Brazil has grown significantly over the years, and genetic improvement is essential to obtain sustainable gains in multiple traits to supply this increasing demand. Thus, the objective of this review was to contribute information concerning the process of popcorn breeding in tropical regions, germplasm availability, popcorn breeding plans, the main characteristics related to popcorn quality and yield, and advances and perspectives in the process of popcorn improvement. The main focus of breeding programs is to obtain hybrids from inbred lines with high popping expansion (40 mL g-1) and yield (4.000 kg ha-1). The genetic improvement performed in Brazil has presented significant advances, mainly due to work developed in public institutions with the development of new hybrids that present more significant popping expansion and yield. However, the number of cultivars is still low, and most of them are controlled by private companies. Therefore, intrapopulation methods are recommended to develop open-pollinated varieties with high popping expansion, and this trait can be used as an early predictor of promising inbred lines to obtain superior hybrids for grain quality. Furthermore, popping expansion can be quickly recovered in backcrosses involving the cross of common maize with an inbred popcorn line.
A COMMERCIAL BREEDING PERSPECTIVE OF MAIZE IMPROVEMENT FOR DROUGHT STRESS TOLERANCE
Authors: NURMBERG PEDRO LUIZ , BRITO ANDRÉ , ZIMMER CRISTIANO MATHIAS , SCHWANTES DIOGO OSWALDO , MANTOVANI EDER EDUARDO , BOSETTI FÁTIMA , ROTUNDO JOSÉ , K. TRUONG SANDRA , BORRAS LUCAS , DE LA VEGA ABERLARDO , MESSINA CHARLIE , F. McCORMICK RYAN
Published: April 2022

As the most produced grain crop in the world, maize (Zea mays) isa cornerstone of the global agricultural economy. Technological innovationsin molecular genetics, environmental characterization, and predictive breedinghave continued to drive genetic gain in maize, even for target populations ofenvironments with high heterogeneity of water availability. Environments proneto drought stress remain key targets where genetic gain must continue to maintain a resilient food supply. Here we review advances towards improving maize drought tolerance; the review focused on molecular and physiological mechanisms underpinning drought tolerance, and methodologies that improve prediction of the genotype by environment interactions under drought conditions.
Comparison of Involute and Cycloidal Engagement in Harmonic Drives
Authors: Lyuminarsky I.E. , Lyuminarsky S.E.
Published: April 2022

Harmonic drives with an involute tooth profile have such faults as noise effects, tooth skips, jamming, increased tooth wear, etc. One of the reasons for the appearance of these shortcomings is the interference of the teeth, which can be caused by an incorrect choice of gear parameters, errors in the manufacture and mounting transmission elements. Interference occurs due to small gaps at the entrance to the engagement of the teeth. To increase these gaps, it is proposed to use cycloidal tooth shapes. To determine the minimum clearance at the entrance to the teeth engagement in involute and cycloidal gears theoretical studies have been carried out. It is shown that in the cycloidal engagement the minimum gap at the entrance to the engagement is much larger than in the involute one. The influence of the moment of resistance on the output shaft and the radial displacement of the cam axis on the specified clearance has been studied.
Computational and experimental study of the working process of a promising rotary piston engine
Authors: Kavtaradze R.Z. , Kasko A.A. , Zelentsov A.A.
Published: April 2022

The article considers mathematical model in a three-dimensional setting developed to study the Wankel engine working process. The verification of the mathematical model is carried out on the basis of measured unsteady pressures in the combustion chamber and in the inlet and outlet ports of a Wankel engine. The engine workflow model is based on the fundamental equations of momentum, energy, diffusion and continuity, written in Reynolds form and supplemented by a k-?-f turbulence model. Fuel combustion was simulated using the Extended Coherent Flame Model (ECFM). Numerical experiments were carried out using the AVL FIRE software package. The paper considers in detail the effect of the movement of the air-fuel mixture in the combustion chamber of a Wankel engine, considering the intake and exhaust processes in adjacent chambers and the gas overflows from the volumes of spark plug channels into the main chamber on the combustion processes and the engine performance. The effect of the movement of the air-fuel mixture in the combustion chamber of a Wankel engine on the combustion processes and engine performance is considered in detail taking into account the processes of intake and exhaust in adjacent chambers and the leakage of the working fluid from the volumes of the spark plug channels into the main chamber.
Quantitative Assessment of the Turbine Flow Generator Parameters Based on the Requirements for Respiratory Systems
Authors: Sedunin V.A. , Marchenko Yu.G. , Kalinin I.A.
Published: April 2022

The article considers the experience of designing a turbine-type flow generator (also known as "turbine", "blower", "centrifugal fan", etc.) for artificial respirators. The system requirements for such a device have been transformed into the geometric and mechanical parameters of the blower in the form adopted in turbomachinery world. These requirements affect not only the pressure and performance indicators, but also the acceleration time (reaching the required operating mode) and the sound pressure level. Special attention is paid to the choice of aerodynamic parameters of the turbo blower, as well as to the specifics of its operation considering the effect of the electric motor torque on its characteristics. The concept of monitoring the residual life of the motor by a vibration sensor and a resistance thermometer, allowing introducing emergency settings in the algorithm controlling the ventilator, is considered. All this will make it possible more reasonable interpretation of the solutions and products presented currently on the market, as well as more detailed considering the specifics of a particular device when developing technical requirement for a blower.
Digital Twins — a Platform for Aircraft Engine Lifecycle Management
Authors: Salnikov A.V. , Gordin M.V. , Shmotin Yu.N. , Nikulin A.S. , Makarov P.V. , Frantsuzov M.S.
Published: April 2022

The article describes the general concept of digital twin (DT) of gas turbine engine (GTE) and methods of its application. A significant part of the digital twin is the requirement matrix (MoR), consisting of requirements for a gas turbine engine structured, formalized and transformed into a database. Considering the MoR, the groups of mathematical models of different degrees of complexity are introduced into the digital twin, allowing inspection of fulfilling requirements and predicting the engine operation. The digital twin is based on a digital platform uniting all its components, it organizes the interfaces between them, forms their hierarchy, stores the revision history and interacts with various databases (internal at the enterprise and external sector-specific ones), third-party digital platforms and services used at different life cycle stages, taking into account their specific features. The use of digital twin technology allows combining into a common information space the complete scope of requirements for the mathematical models being developed, various digital services and a variety of data created, received and used throughout the life cycle of a gas turbine engine. Such combination will increase transparency and understanding what happens to the engine at various stages of its life cycle, improve performance, reduce time for developing and certification, and reduce the prime cost of its production and operation.
Evaluación de captura de carbono en sistemas productivos de café en el departamento de Nariño
Authors: Manchabajoy Cañar Juan Pablo , Andrade Díaz Danita , Castillo Marín Álvaro José
Published: April 2022

Uno de los problemas ambientales más grandes que ha afectado al planeta es el calentamiento global, por las altas concentraciones de carbono (CO2), esto ha llevado a que cultivos como el café se vean afectados por el cambio climático causado por los gases efecto invernadero (GEI), especialmente por el incremento en la incidencia de plagas y enfermedades. Sin embargo, a través de captura de carbono se contribuye con la mitigación de emisión de GEI. El objetivo de este trabajo fue evaluar el carbono almacenado en la biomasa aérea y bajo el suelo en cuatro sistemas productivos de café castillo de seis años de edad. En un ensayo establecido bajo diseño de bloques completos al Azar (DBCA) con los tratamientos Café a libre exposición (T1), Café-Limón (T2), Café-Guamo (T3) y Café-Carbonero (T4), en tres altitudes: menor a los 1550 msnm, entre los 1550 y 2000 msnm y sobre los 2000 msnm. Se recolectaron datos correspondientes a los diámetros de tallo de plántulas de café y árboles de sombrío con los cuales se aplicaron ecuaciones alométricas para obtener las variables carbono en la biomasa aérea y en raíz y las variables carbono en hojarasca y suelo obtenidos a partir de su materia seca. Se obtuvo diferencias altamente significativas en los cuatro tratamientos evaluados, siendo T4 el que mayor concentración de carbono obtuvo tanto en la biomasa del suelo con 100,14 t ha-1 como en la biomasa aérea con 190,42 t ha-1.
Facultad de Ingeniería de Sistemas de la Universidad “San Luis Gonzaga” de Ica con énfasis en el In between
Authors:   , Peña Huamán Olenka del Rosario
Published: April 2022

La facultad de Ingeniería de Sistemas busca brindar a la comunidad estudiantil de la universidad San Luis Gonzaga de Ica una infraestructura de acorde a las necesidades educativas de la carrera; de manera que dicha infraestructura no solo sea una casa de estudios, sino que se convierta en parte de la formación educativa. También responder a las relaciones sociales de esta generación estudiantil a través de los principios del In between, los cuales permiten crear espacios de encuentro; lugares de transición entre dos realidades y un recorrido espacial que genera dinamismo en la arquitectura.
Pluralisme Hukum Dalam Tradisi Perkawinan Sasuku Pada Masyarakat Minang
Authors: Irzak Yuliardy Nugroho  , Mufidah CH  , Suwandi
Published: April 2022

Penelitian ini mengkaji tradisi larangan perkawinan sasuku pada masyarakat Minang. Aturan tersebut mengakibatkan banyaknya aturan hukum yang berjalan pada masyarakat Minang, hukum adat, hukum Islam, dan hukum negara. Banyaknya aturan hukum tersebut, menjadikan hukum perkawinan masyarakat minang terkesan abu-abu, disatu sisi harus menaati hukum Islam dan hukum negara yang tidak mengatur tentang larangan perkawinan sasuku. Sementara, di lain hal ada adat yang membuat aturan tentang larangan perkawinan sasuku. Penelitian ini menggunakan paradigma kualitatif, dengan jenis penelitian conseptual approach. Adapun data yang digunakan adalah data sekunder dari beberapa jurnal, yang kemudian dikombinasikan dengan fakta hukum masyarakat Minang tentang larangan perkawinan sasuku tersebut. Kesimpulan menunjukkan bahwa terjadinya pluralisme hukum perkawinan pada masyarakat Minang merupakan keniscayaan sosial. Larangan perkawinan sasuku, selain memberikan dampak pada tertib sosial, juga mengancam eksistensi hukum islam pada aspek perkawinan dalam ihwal penentuan jodoh, termasuk menegasikan hukum perkawinan Indonesia tentang perkawinan yang dilakukan dengan kondisi sukarela dari kedua pihak.
Obesity during pregnancy and its oral repercussions
Authors: Foratori-Junior Gerson Aparecido , Sales-Peres Silvia Helena de Carvalho
Published: April 2022

Obesity during pregnancy and its oral repercussions: what is the current evidence?
EARLY DETECTION TRAINING OF HEARING DISORDERS IN THE ERA OF THE COVID 19 PANDEMIC FOR HEALTH PERSONNEL AT GENTENG KULON BANYUWANGI HEALTH CENTER, EAST JAVA
Authors: Nugroho Puguh Setyo , Purnami Nyilo , Perdana Rizka Fathoni , Falerina Rosa , Rakhma Hendra Kurnia
Published: April 2022

The COVID 19 pandemic impacts the early detection of hearing impairment. Socialization is needed in the form of early detection education of hearing loss in the era of the COVID 19 pandemic to health workers in the front line. The purpose of educational activities is to improve the knowledge and skills of health workers to conduct early detection of hearing impairment in the era of the COVID 19 pandemic. The condition of the COVID 19 pandemic changed the interaction pattern between people, including in education and training activities in the field of health. Education with on line means is becoming a common thing to do today. This training activity is conducted on line and off line methods with limited participants. The training for health workers was carried out using an off line method and was attended by 39 participants. The average result of the pre test was 45.20 (+ 15.69), and the average post test was 80.67 (+ 22.73). Comparison of the pre test and post test results with the t-test, the results were significantly different (p < 0.0001). The training with the on line method was attended by 1,145 participants. The results of the average pre test score were 55.30 (+15.61), and the post test average score was 72.82 (+21.61). Comparison of the pre test and post test scores with the t-test results was significantly different (p < 0.0001). On line and off line methods in training activities provide significant results in increasing the knowledge of health workers so that the pandemic does not hinder the implementation of training activities to increase the knowledge of health workers in an effort to improve the quality of life of the community, in this case, hearing.
OPTIMALISASI 1000 HARI PERTAMA KEHIDUPAN PADA MASA ADAPTASI BARU COVID-19 MELALUI PENDAMPINGAN IBU HAMIL DAN PELATIHAN KADER DI KABUPATEN BONDOWOSO, JAWA TIMUR
Authors: Izzati Dwi , Amalia Rize Budi , Ningrum Astika Gita
Published: April 2022

Pada kondisi normal kesehatan ibu dan anak di Indonesia masih menjadi tantangan besar dan diperberat dengan adanya pandemi Covid-19 yang berlangsung sejak bulan Maret 2020 yang berdampak pada adanya batasan dalam hal akses dan kualitas pelayanan. Kekhawatiran yang muncul karena batasan ini adalah adanya peningkatan morbiditas dan mortalitas Ibu dan anak serta penurunan cakupan pelayanan KIA. Kegiatan pengabdian masyarakat ini dilakukan secara daring dan luring dengan tetap menjaga ketat protokol kesehatan. Kegiatan yang dilakukan secara daring yaitu Pelatihan Kader Posyandu Ibu-Balita tentang Perencanaan Persalinan dan Pelatihan Kader Posyandu Ibu-Balita tentang Stimulasi Pertumbuhan, sedangkan kegiatan yang dilakukan secara luring adalah Pelatihan Kader Posyandu Ibu-Balita tentang Optimalisasi Kehamilan dan Pendampingan Ibu Hamil. Kegiatan pengabdian masyarakat yang telah dilakukan berhasil menaikkan pengetahuan ibu. Hal yang paling berpengaruh dalam kegiatan ini kondisi pandemi yang tidak terduga membuat program pengmas harus lebih fleksibel menyesuaikan situasi dan prioritas keamanan bagi para pelaksana pengmas, sehingga direnacakan untuk kegiatan tindak lanjut berupa pendampingan yang akan dilanjutkan oleh mahasiswa prodi kebidanan dengan pengawasan oleh dosen dan bidan wilayah setempat.
Virgin coconut oil protected the diameter and the epithelium thickness of seminiferous tubules of mice (Mus musculus) from oral ethanol induction
Authors: S Ravi Vishantheni , Soeharsono Soeharsono , Plumeriastuti Hani , Rachmawati Kadek
Published: April 2022

This study investigated the preventive effect of virgin coconut oil (VCO) on the epithelium thickness and the diameter of the seminiferous tubules induced by ethanol in mice (Mus musculus). This study used 20 male mice as the experimental animal which were divided into five groups with four mice in each group. Negative control (C-) was given 2% Tween and aquadest, while positive control (C+) was given 2% Tween and 33% ethanol. T1, T2, and T3 were respectively given 0.09, 0.19, and 0.37 mL/kg bw VCO and 33% ethanol (0.2 mL/kg bw). VCO was given orally for 39 days, and ethanol was given orally seven days later for 32 days. Ethanol was administered two hours after the VCO administration. Analysis of variance followed by Tukey’s range test on the epithelium thickness and the diameter of the seminiferous tubules showed significant differences (p <0.05) of C+ group from the other groups. Whereas, there was no significant difference (p >0.05) was found among C-, T1, T2 and T3 group. The result concluded that VCO could protect the testis of mice from the damage caused by ethanol.
Uterine torsion in Simmental crossbreed cow
Authors: Rahayu Sri
Published: April 2022

This case report describes the treatment of uterine torsion in Simmental crossbreed cattle. The dam was five years old, twice parity, in nine months and ten days pregnancy. Based on the anamnesis, it is known that the cows show signs of restlessness, straining, more robust by the time. However, there was no visible edema in the vulva, no ruptured membranes, no legs and head of the fetus coming out of the dam's vulva. Tretment was carried out by traditional rolling until the maximum uterine lumen opening was obtained. The position of the fetus is head flexion posture, so to remove it vaginally, the head is repositioned first and then forced to pull it out until the fetus comes out. Post-treatment, the dam's condition was still weak, unable to stand up, did not want to eat, and only drank a little. The drugs given were analgesics-antipyretics (repeated in the afternoon), long-acting antibiotics, vitamin B1, and vitamins and minerals mixed. After a few hours, the dam was up and walking around, feeding and drinking, and the placenta completely separated. The fetus's condition was alive, female sex, weak condition, the condition improves after being given milk from the dam. It can be concluded that the case of uterine torsion in Simmental crossbreed cows has been successfully treated 24 hours after the signs of birth using the traditional rolling technique, and the fetus can be expelled vaginally. The condition of the dam and fetus after the treatment of uterine were torsion gradually became healthy.
Different E-box binding transcription factors, similar neuro-developmental defects: ZEB2 (Mowat-Wilson syndrome) and TCF4 (Pitt-Hopkins syndrome)
Authors: Meert Lize , Birkhoff Judith C. , Conidi Andrea , Poot Raymond A. , Huylebroeck Danny
Published: April 2022

ZEB2 and TCF4 are transcription factors (TFs) whose locations in embryos overlap in many sites and developmental phases, including in the forebrain and its cortical neurons. De novo mutations cause the phenotypically overlapping, haploinsufficient Mowat-Wilson (MOWS, in the ZEB2 gene) and Pitt-Hopkins (PTHS, in TCF4) syndromes, which currently cannot be cured. Mutant alleles have been mapped and defects documented (also in brain function) in MOWS and PTHS patients. Appropriately designed mouse models and cells derived from these, as well as cellular models including cultured pluripotent cells, enable investigating the genetic and molecular mechanisms underlying the developmental deficiencies that manifest after birth in the nervous systems and their multiple cell types, as well as those of organs other than the brain, in MOWS and PTHS. Biochemical analyses of cell type-specific transcriptomic changes in these perturbation models as compared to control cells, the identification of the intact-factor dependent and direct target genes, and of partner proteins including chromatin modulators, are revealing complex and multiple modes of action that eventually will explain target gene selectivity for these TFs. Both TFs have also been found to operate in acute and chronic diseases and cell-based repair processes after tissue or organ injury. In addition, the defective function also arises from their aberrant gene expression, which will require a deeper investigation of how the transcription of these TF genes is regulated. Furthermore, these two factors genetically and biochemically interact. This review combines the essentials and recent progress for both TFs for the first time, with a focus on MOWS and PTHS.