bluuebunny/crossref_metadata_2025 huggingface dataset:
Influence of Pozzolans and Hemp Shives on the Properties of Non-Autoclaved Foamed Concrete
Authors: Mohamad Abdelrahman , Khadraoui Fouzia , Boutouil Mohamed , Chateigner Daniel
Published: January 2023

In this study, new foam concretes incorporating hemp shives without the use of autoclaving have been developed and studied. Several protocols and parameters were investigated. Firstly, the influence of the addition of pozzolanic additives on the resulting density, mechanical behaviour and thermal conductivity was examined. Secondly, the effects of the incorporation of hemp shives at 5, 10 and 15 vol% on the previous three properties in such concretes were investigated. Moreover, economic cost and CO2 emissions were estimated to outline an optimized formulation of non-autoclaved biobased foam concretes. First, the target characteristics in terms of compressive strength (minimum of 2 MPa), thermal conductivity (less than 0.2 Wm−1K−1) and density (800 kg/m3) were achieved. It was noted that pozzolanic additions slightly improved the mechanical and thermal strength of non-autoclaved foamed concrete, while the addition of hemp shives improved the thermal strength but had an unfavourable effect on the mechanical strength. Moreover, both reduced the CO2 emissions.
Frequency Properties of Polymer Bonded Compacts Obtained from Ball Milled Permalloy Powders with Mo and Cu Additions
Authors: Popa Florin , Isnard Olivier , Neamțu Bogdan Viorel , Chicinaș Ionel
Published: January 2023

Nanocrystalline powders from the Permalloy family, Ni75Fe25, Ni79Fe16Mo5, and Ni77Fe14Cu5Mo4, were obtained by mechanical alloying starting from elemental powders. All compositions were milled for up to 24 h in a high-energy planetary ball mill. The powders were single phase and nanocrystalline as determined by X-ray diffraction studies, with larger flatted particle sizes for Ni75Fe25 (about 400 μm) and Ni77Fe14Cu5Mo4 (about 470 μm), and smaller particle sizes for Ni79Fe16Mo5 (about 170 μm). The homogeneity of the samples was verified by energy-dispersive X-ray spectroscopy (EDX). Soft magnetic composites were obtained by adding 3% of Araldite to the powders, followed by compaction at 700 MPa, and then polymerization. A very good powder covering by the polymer layer was proven by EDX elementals maps. The influence of composition change on the electrical resistivity of the compacts was studied. Hysteresis measurements in static and dynamic fields of up to 10 kHz were recorded, showing the influence of composition and particle size on the compact properties.
Electrodeposition of Stable Noble-Metal-Free Co-P Electrocatalysts for Hydrogen Evolution Reaction
Authors: Kim Jeongwon , Jang Yu Jin , Jang Yoon Hee
Published: January 2023

Hydrogen production via water splitting has been extensively explored over the past few decades, and considerable effort has been directed toward finding more reactive and cost-effective electrocatalysts by engineering their compositions, shapes, and crystal structures. In this study, we developed hierarchical cobalt phosphide (Co-P) nanosphere assemblies as non-noble metal electrocatalysts via one-step electrodeposition. The morphologies of the Co-P nanostructures and their electrocatalytic activities towards the hydrogen evolution reactions (HER) were controlled by the applied potentials during electrodeposition. The physicochemical properties of the as-prepared Co-P nanostructures in this study were characterized by field-emission scanning electron microscopy, X-ray photoemission spectroscopy and X-ray diffraction. Linear sweep voltammetry revealed that the Co-P grown at −0.9 V showed the best HER performance exhibiting the highest electrochemical active surface area and lowest interfacial charge transfer resistance. The Co-P electrocatalysts showed superior long-term stability to electrodeposited Pt, indicating their potential benefits.
Recent Advances in Structured Catalytic Materials Development for Conversion of Liquid Hydrocarbons into Synthesis Gas for Fuel Cell Power Generators
Authors: Shilov Vladislav , Potemkin Dmitriy , Rogozhnikov Vladimir , Snytnikov Pavel
Published: January 2023

The paper considers the current state of research and development of composite structured catalysts for the oxidative conversion of liquid hydrocarbons into synthesis gas for fuel cell feeding and gives more detailed information about recent advances in the Boreskov Institute of Catalysis. The main factors affecting the progress of the target reaction and side reactions leading to catalyst deactivation are discussed. The properties of the Rh/Ce0.75Zr0.25O2/Al2O3/FeCrAl composite multifunctional catalyst for the conversion of diesel fuel into synthesis gas are described. The results of the catalyst testing and mathematical modeling of the process of diesel fuel steam–air conversion into synthesis gas are reported.
Creep Crack Growth Behavior during Hot Water Immersion of an Epoxy Adhesive Using a Spring-Loaded Double Cantilever Beam Test Method
Authors: Nakamura Kota , Sekiguchi Yu , Shimamoto Kazumasa , Houjou Keiji , Akiyama Haruhisa , Sato Chiaki
Published: January 2023

Double cantilever beam (DCB) tests were conducted by immersing the specimens in temperature-controlled water while applying a creep load using a spring. By introducing a data reduction scheme to the spring-loaded DCB test method, it was confirmed that only a single parameter measurement was sufficient to calculate the energy release rate (ERR). Aluminum alloy substrates bonded with an epoxy adhesive were used, and DCB tests were performed by changing the initial load values, spring constants, and immersion temperatures for two types of surface treatment. The initial applied load and spring constant had no effect on the ERR threshold. In contrast, the threshold decreased with the increasing immersion temperature, but even in the worst case, it was 15% of the critical ERR in the static tests. Using the creep crack growth relationship, it was revealed that there were three phases of creep immersion crack growth in the adhesive joints, and each phase was affected by the temperature. The spring-loaded DCB test method has great potential for investigating the combined effects of creep, moisture, and temperature, and this study has demonstrated the validity of the test method. The long-term durability of adhesive joints becomes increasingly important, and this test method is expected to become widespread.
Porous Structural Properties of K or Na-Co Hexacyanoferrates as Efficient Materials for CO2 Capture
Authors: Frías-Ureña Paloma M. , Bárcena-Soto Maximiliano , Orozco-Guareño Eulogio , Gutiérrez-Becerra Alberto , Mota-Morales Josué D. , Chavez Karina , Soto Víctor , Rivera-Mayorga José A. , Escalante-Vazquez José I. , Gómez-Salazar Sergio
Published: January 2023

The stoichiometry of the components of hexacyanoferrate materials affecting their final porosity properties and applications in CO2 capture is an issue that is rarely studied. In this work, the effect that stoichiometry of all element components and oxidation states of transition metals has on the structures of mesoporous K or Na-cobalt hexacyanoferrates (CoHCFs) and CO2 removal is reported. A series of CoHCFs model systems are synthesized using the co-precipitation method with varying amounts of Co ions. CoHCFs are characterized by N2 adsorption, TGA, FTIR-ATR, XRD, and XPS. N2 adsorption results reveal a more developed external surface area (72.69–172.18 m2/g) generated in samples containing mixtures of K+/Fe2+/Fe3+ ions (system III) compared to samples with Na+/Fe2+ ions (systems I, II). TGA results show that the porous structure of CoHCFs is affected by Fe and Co ions oxidation states, the number of water molecules, and alkali ions. The formation of two crystalline cells (FCC and triclinic) is confirmed by XRD results. Fe and Co oxidation states are authenticated by XPS and allow for the confirmation of charges involved in the stabilization of CoCHFs. CO2 removal capacities (3.04 mmol/g) are comparable with other materials reported. CO2 adsorption kinetics is fast (3–6 s), making CoHCFs attractive for continuous operations. Qst (24.3 kJ/mol) reveals a physical adsorption process. Regeneration effectiveness for adsorption/desorption cycles indicates ~1.6% loss and selectivity (~47) for gas mixtures (CO2:N2 = 15:85). The results of this study demonstrate that the CoHCFs have practical implications in the potential use of CO2 capture and flue gas separations.
Temperature Field and Stress Analysis of the Heavy-Concrete Transfer–Purge Chamber of the Nuclear Power Plant
Authors: Wang Xiaohui , Li Xiaojun , Liu Xuchen , Wang Yushi , Liu Aiwen , He Qiumei , Hou Chunlin
Published: January 2023

A transfer–purge chamber (TPC) is a double-steel-plate, heavy-concrete, curved-surface composite structure composed of steel plates, heavy concrete, and shear connectors. It is an important facility in the external refueling system of a nuclear power plant (NPP), providing a safe and reliable biological shielding space for reactor refueling operations. Temperature load is one of the most important factors that must be considered in the design of NPP structures. The temperature loads experienced by the TPC during its life cycle include those encountered in both normal and abnormal operation, which are distinct. In this study, we investigated the steady state and transient-state temperature fields and stresses of a TPC structure under normal operation and after 48 h of abnormal operation, respectively, which were calculated using Abaqus finite element software and the directly coupled method. During normal operation, the temperature field of the structure shows relatively uniform changes, and the temperature gradient of the internal concrete in the direction of its thickness has a constant value of 0.245 °C/cm. At the junction between the transfer and purge sub-chambers of the TPC, under the influence of wall curvature and deformation constraints, the maximum tensile strain of heavy concrete is 8.84 × 10−3, the maximum compressive strain is 2.04 × 10−3, the peak stress of the steel plate is 98.305 MPa, and the peak stress of the stud is 306.725 MPa. After 48 h of abnormal operation, the temperatures of the inner surface of the heavy concrete of the wall, the inner steel plate of the wall, the outer surface of the heavy concrete of the wall, and the inner steel plate of the wall increased by 8.12, 8.11, 0.31, and 0.30 °C, respectively. The tensile strain of the heavy concrete of the wall increased significantly by 52.64%, and the compressive strain of the concrete increased by 67.33%, whereas the stresses of the studs and steel plates increased by only 1.57% and 6.79%, respectively. These results show that the change in the temperature field greatly influences the stress and strain on the TPC structure. As measures for mitigating the development of this unfavorable situation of temperature stress concentration, the temperature operating range should be rationally controlled or the junction structure between the transfer and purge sub-chambers of the TPC optimized accordingly. The results of our study can provide basic data for a dynamic analysis of the TPC under conditions of combined earthquake and temperature loads.
Comparison of the Prediction of Effective Moment of Inertia of FRP Rebar-Reinforced Concrete by an Optimization Algorithm
Authors: Jang Nag-Seop , Kim Young-Hwan , Oh Hong-Seob
Published: January 2023

FRP (fiber-reinforced polymer)-reinforced concrete members have larger deflection than reinforced concrete members because of the low modulus of elasticity of the FRP bar. In this paper, we proposed a new effective moment of inertia equation to predict the deflection of FRP-reinforced concrete members based on the harmony search algorithm. The harmony search algorithm is used to optimize a function that minimizes the error between the deflection value of the experimental result and the deflection value expected from the specimen’s specifications. In the experimental part, four GFRP (Glass Fiber-Reinforced Polymer)- and BFRP (Basalt Fiber-Reinforced Polymer)-reinforced concrete slab specimens were manufactured and tested. FRP-reinforced concrete slabs were reinforced with GFRP and BFRP rebars on spiral rib surfaces. The effects of the FRP reinforcement ratio and balanced reinforcement ratio (ρf/ρfb), the moment of inertia of the transformed cracked section and the gross moment of inertia (Icr/Ig), and the cracking moment and the maximum service load moment (Mcr/Ma) on the effective moment of inertia have been considered. The experimental results and predicted results of the flexural testing of concrete slabs reinforced with FRP rebars were compared, and the experimental results were in good agreement with the calculated values using the proposed effective moment of inertia equation.
Architecture of Nanoantioxidant Based on Mesoporous Organosilica Trp-Met-PMO with Dipeptide Skeleton
Authors: Zhou Wanli , Ma Haohua , Dai Yunqiao , Du Yijing , Guo Cheng , Wang Jianqiang
Published: January 2023

A nanoantioxidant of mesoporous organosilica (Trp-Met-PMO) based on the framework of tryptophan–methionine dipeptide was first designed and constructed by condensation between self-created dipeptide organosilica precursor (Trp-Met-Si) and tetraethyl orthosilicate (TEOS) in alkaline conditions under the template hexadecyl trimethyl ammonium bromide (CTAB). Trp-Met-Si was prepared by the reaction between dipeptide Trp-Met and conventional organosilicon coupling agent isocyanatopropyltriethoxysilane (IPTES) via a multiple-step reaction method. The material Trp-Met-PMO was confirmed by XRD, FT-IR and N2 adsorption–desorption analysis. The material Trp-Met-5-PMO with low amounts of organosilica precursor remained a mesoporous material with well-ordered 2D hexagonal (P6mm) structure. With increasing amounts of organosilica precursor, a mesoporous structure was still formed, as shown in the material Trp-Met-100-PMO with the highest amounts of organosilica precursor. Moreover, pore size distribution, surface area and porosity of Trp-Met-PMO are regulated with different amounts of organosilica precursor Trp-Met-Si. The antioxidant activity of Trp-Met-PMO was evaluated by ABTS free radical-scavenging assay. The results showed that antioxidant activity was largely enhanced with increasing contents of organosilica precusor Trp-Met-Si in the skeleton. The material Trp-Met-40-PMO exhibited maximum scavenging capacity of ABTS free radicals, the inhibition percent was 5.88%. This study provides a design strategy for nanoantioxidant by immobilizing short peptides within the porous framework of mesoporous material.
Temperature Patterns in TSA for Different Frequencies and Material Properties: A FEM Approach
Authors: Duarte Guilherme , Neves Ana , Ramos Silva António
Published: January 2023

Thermography techniques are gaining popularity in structural integrity monitoring and analysis of mechanical systems’ behavior because they are contactless, non-intrusive, rapidly deployable, applicable to structures under harsh environments, and can be performed on-site. More so, the use of image optical techniques has grown quickly over the past several decades due to the progress in the digital camera, infrared camera, and computational power. This work focuses on thermoelastic stress analysis (TSA), and its main goal was to create a computational model based on the finite element method that simulates this technique, to evaluate and quantify how the changes in material properties, including orthotropic, affect the results of the stresses obtained with TSA. The numeric simulations were performed for two samples, compact and single lap joints. when comparing the numeric model developed with previous laboratory tests, the results showed a good representation of the stress test for both samples. The created model is applicable to various materials, including fiber-reinforced composites. This work also highlights the need to perform laboratory tests using anisotropic materials to better understand the TSA potential and improve the developed models.
Case Report: Performing a Medication Safety Review Assisted by Pharmacogenomics to Explain a Prescribing Cascade Resulting in a Patient Fall
Authors: Russell Joshua , Arwood Meghan J. , Toro-Pagán Nicole M. Del , Amin Nishita S. , Cambridge Michele D. , Turgeon Jacques , Michaud Veronique
Published: January 2023

Pharmacotherapy for major depressive disorder (MDD) typically consists of trial-and-error and clinician preference approaches, where patients often fail one or more antidepressants before finding an optimal regimen. Pharmacogenomics (PGx) can assist in prescribing appropriate antidepressants, thereby reducing the time to MDD remission and occurrence of adverse drug events. Since many antidepressants are metabolized by and/or inhibit cytochrome P450 enzymes (e.g., CYP2C19 or CYP2D6), drug-induced phenoconversion is common in patients on antidepressant combinations. This condition influences the interpretation of a patient’s PGx results, overall risk of ineffective/adverse medication response due to multi-drug interactions, and the recommendations. This complex case describes a patient with MDD, generalized anxiety disorder, and chronic pain who experienced a fall due to excessive sedation following a prescribing cascade of fluoxetine, bupropion, and doxepin. These antidepressants delivered a significant additive sedative effect and interacted with the patient’s hydrocodone, potentially contributing to uncontrolled pain, upward dose titration of hydrocodone, and a higher overall sedative burden. The PGx results and drug-induced phenoconversion described in this case report explain the patient’s excessive sedation and possibly ineffective/toxic antidepressant and opioid treatment. This case report also illustrates how a more timely multi-drug interaction assessment (preferably in conjunction with preemptive PGx testing) may have informed a different prescribing pattern, reduced/avoided a prescribing cascade, and potentially prevented a drug-related fall.
Comparison between Retrograde Flexible Ureteroscopy and Percutaneous Nephrolithotomy for the Treatment of Renal Stones of 2–4 cm
Authors: Cosmin Cozma , Georgescu Dragos Adrian , Geavlete Petrisor , Popescu Razvan-Ionut , Geavlete Bogdan
Published: January 2023

Background and objectives: Renal stones are widespread, with a lifetime prevalence of 10% in adults. Flexible ureteroscopy enables urologists to treat lower calyx stones or even complex renal stones through the natural orifice and achieve an acceptable stone-free rate. Hence, we analyzed the effectiveness and safety of FURS versus PCNL in treating renal stones between 20 and 40 mm in diameter. Materials and methods: We retrospectively analyzed 250 consecutive patients with large renal solitary stones (stone burden between 2 and 4 cm) from 1 January 2019 to 31 December 2020. The patients were divided into two groups: group 1 (125 patients), in which the patients were treated by a retrograde flexible ureteroscopic approach, and group 2 (125 patients), in which we used percutaneous nephrolithotomy. Stone characteristics and anatomical data were observed based on the computed tomography (CT) and/or KUB (Kidney-ureter-Bladder) radiography imaging archive. Results: The mean stone burden was 26.38 ± 4.453 mm in group 1 and 29.44 ± 4.817 mm in group 2. The stone-free rate after the first ureteroscopy was higher for the PNL(percutaneous nephrolithotomy) group (90.4%) than the F-URS group (68%). After two sessions of ureteroscopy, the SFR was 88.8% in the first group, and after three procedures, the SFR rose to 95.2%. The overall complication rate was higher in group 1 than in group 2 (18.4% vs. 16.8%), but without statistical relevance (p > 0.5). Furthermore, we encountered more grade III and IV complications in the PNL group (8.8% vs. 4.8%, p < 0.05). Conclusion: Flexible ureteroscopy proves to be efficient in treating renal stones over 2 cm. However, the patients must be informed that more than one procedure might be necessary to overcome the entire stone burden.
Pre-Surgery Patient Health Contributes to Aggravated Sino-Nasal Outcome and Quality of Life after Pituitary Adenomectomy
Authors: Chmielewski Witold X. , Walbrodt Sebastian , Rauschenbach Laurèl , Chihi Mehdi , Gembruch Oliver , Darkwah Oppong Marvin , Schroer Sebastian , Wrede Karsten H. , Dammann Philipp , Jabbarli Ramazan , Kreitschmann-Andermahr Ilonka , Sato Taku , Unger Nicole , Mattheis Stefan , Sure Ulrich , Ahmadipour Yahya
Published: January 2023

Objectives: The transphenoidal bi-nostril endoscopic resection of pituitary adenomas is regarded as a minimally invasive treatment nowadays. However, sino-nasal outcome and health-related quality of life (HRQoL) might still be impaired after the adenomectomy, depending on patients’ prior medical history and health status. A systematic postoperative comparison is required to assess differences in perceived sino-nasal outcome and HRQoL. Methods: In this single-center observational study, we collected data from 81 patients, operated between August 2016 and August 2021, at a 3–6-month follow-up after adenomectomy. We employed the sino-nasal outcome test for neurosurgery (SNOT-NC) and the HRQoL inventory Short Form (SF)-36 to compare sino-nasal and HRQoL outcome in patients with or without allergies, previous nose surgeries, presence of pain, snoring, sleep apnea, usage of continuous positive airway pressure (cpap), and nose drop usage. Results: At the 3–6-month follow-up, patients with previous nasal surgery showed overall reduced subjective sino-nasal health, increased nasal and ear/head discomfort, increased visual impairment, and decreased psychological HRQoL (all p ≤ 0.026) after pituitary adenomectomy. Patients with pain before surgery showed a trend-level aggravated physical HRQoL (p = 0.084). Conclusion: Our data show that patients with previous nasal surgery have an increased risk of an aggravated sino-nasal and HRQoL outcome after pituitary adenomectomy. These patients should be thoroughly informed about potential consequences to induce realistic patient expectations. Moreover, the study shows that patients with moderately severe allergies, snoring, and sleep apnea (± cpap) usually do not have to expect a worsened sino-nasal health and HRQoL outcome.
The Association of Beta-Blocker Use and Bone Mineral Density Level in Hemodialysis Patients: A Cross-Sectional Study
Authors: Anumas Suthiya , Thitisuriyarax Saranya , Tantiyavarong Pichaya , Pholsawatchai Waroot , Pattharanitima Pattharawin
Published: January 2023

Background and Objectives: Osteoporosis results in increasing morbidity and mortality in hemodialysis patients. The medication for treatment has been limited. There is evidence that beta-blockers could increase bone mineral density (BMD) and reduce the risk of fracture in non-dialysis patients, however, a study in hemodialysis patients has not been conducted. This study aims to determine the association between beta-blocker use and bone mineral density level in hemodialysis patients. Materials and Methods: We conducted a cross-sectional study in hemodialysis patients at Thammasat University Hospital from January 2018 to December 2020. A patient receiving a beta-blocker ≥ 20 weeks was defined as a beta-blocker user. The association between beta-blocker use and BMD levels was determined by univariate and multivariate linear regression analysis. Results: Of the 128 patients receiving hemodialysis, 71 were beta-blocker users and 57 were non-beta-blocker users (control group). The incidence of osteoporosis in hemodialysis patients was 50%. There was no significant difference in the median BMD between the control and the beta-blocker groups of the lumbar spine (0.93 vs. 0.91, p = 0.88), femoral neck (0.59 vs. 0.57, p = 0.21), total hip (0.73 vs. 0.70, p = 0.38), and 1/3 radius (0.68 vs. 0.64, p = 0.40). The univariate and multivariate linear regression analyses showed that the beta-blocker used was not associated with BMD. In the subgroup analysis, the beta-1 selective blocker used was associated with lower BMD of the femoral neck but not within the total spine, total hip, and 1/3 radius. The multivariate logistic regression showed that the factors of age ≥ 65 years (aOR 3.31 (1.25–8.80), p = 0.02), female sex (aOR 4.13 (1.68–10.14), p = 0.002), lower BMI (aOR 0.89 (0.81–0.98), p = 0.02), and ALP > 120 U/L (aOR 3.88 (1.33–11.32), p = 0.01) were independently associated with osteoporosis in hemodialysis patients. Conclusions: In hemodialysis patients, beta-blocker use was not associated with BMD levels, however a beta-1 selective blocker used was associated with lower BMD in the femoral neck.
Evaluating Possible Changes in Air Temperature and Precipitation Patterns in Mozambique by Comparing Present and Future RegCM4 Simulation
Authors: Sumila Telmo Cosme A. , Ferraz Simone E. T. , Durigon Angelica
Published: January 2023

Unlike global and regional assessments, the spatio-temporal variability of air temperature and precipitation, caused by climate change, must be more useful when the assessment is made at the sub-regional to local scale. Thus, this study aims to assess the possible changes in air temperature and precipitation in patterns for the late 21st century relative to the present climate in Mozambique. The regional model, RegCM4, driven by the global model HadGEM2, was used to perform the downscaling process under two Representative Concentration Pathways (RCPs), moderate RCP4.5 and strong RCP8.5. The three experiments were analyzed in the baseline (1971–2000) and future (2070−2099) range at the subregional scale in Mozambique. In this study domain, the highest amounts of precipitation and the highest air temperatures are observed during the extended summer season. However, the central region is rather warmer and rainier than the northern- and southernmost regions. Hence, the regional model RegCM4 demonstrated agreement relative to the observed weather stations and interpolated dataset from the Climate Research Unit. The strong performance of RegCM4 is revealed by its more realistic local spatio-temporal climate features, tied to the topography and geographical location of the study domain. The future increases in mean annual air temperature are well simulated by the model but, the spatial distribution and magnitude differ between the RCPs and over each of the three regions throughout the country. The sharp hottest response at the end of 21st century occurs in the summer and spring seasons under RCP8.5, spatially over the central and northern region of the study domain, with a hot-spot in the southern region. There is a predominantly drier response in the annual mean precipitation but, during the summer season, a meridional dipolarization pattern is observed, with the wettest response being over the southernmost region and a drier response in the northern and central regions of Mozambique.
Design and Simulation of a Magnetization Drive Coil Based on the Helmholtz Principle and an Experimental Study
Authors: Zhao Changlong , Lv Qiyin , Yang Junbao , Li Ming , Zhao Qinxiang , Ma Hongnan , Jia Xiaoyu
Published: January 2023

In order to realize the magnetization of hydrogel mixed with NdFeB powder, a magnetization drive coil based on a Helmholtz coil is designed in this paper. The 3D model of the magnetic field system is drawn by the Maxwell software 3D module, and the influence of different factors on the magnetic induction intensity is analyzed to obtain the optimized structure of the magnetization drive coil; then, the central magnetic induction intensity and magnetic induction line distribution density of the magnetization drive coil and Helmholtz coil are compared to verify the reliability of the structure optimization. The results show that the central magnetic induction intensity is the highest when the distance between the auxiliary coils is 70 mm, the central magnetic induction intensity of the magnetized drive coil is significantly higher than that of the Helmholtz coil when the number of turns is the same, and the central magnetic induction intensity of the optimized magnetized drive coil can reach 1.37 T with a more uniform and dense magnetic induction line distribution. After building the magnetization drive coil, the magnetic induction intensity of the center of the magnetization drive coil can reach 1.34 T by a handheld digital Gauss meter test, and the error is no more than 2% with the simulation result. This design approach provides a reference for the structural design and operating characteristics analysis of magnetized drive coils and shortens the design cost and development cycle of magnetized drive coils.
Aluminum Nitride-Based Adjustable Effective Electromechanical Coupling Coefficient Film Bulk Acoustic Resonator
Authors: Qu Yuanhang , Luo Tiancheng , Wen Zhiwei , Wei Min , Gu Xiyu , Chen Xiang , Zou Yang , Cai Yao , Liu Yan , Sun Chengliang
Published: January 2023

The arrival of the 5G era has promoted the need for filters of different bandwidths. Thin-film bulk acoustic resonators have become the mainstream product for applications due to their excellent performance. The Keff2 of the FBAR greatly influences the bandwidth of the filter. In this paper, we designed an AlN-based adjustable Keff2 FBAR by designing parallel capacitors around the active area of the resonator. The parallel capacitance is introduced through the support column structure, which is compatible with conventional FBAR processes. The effects of different support column widths on Keff2 were verified by finite element simulation and experimental fabrication. The measured results show that the designed FBAR with support columns can achieve a Keff2 value that is 25.9% adjustable.
Radiation Hardness Study of Silicon Carbide Sensors under High-Temperature Proton Beam Irradiations
Authors: Medina Elisabetta , Sangregorio Enrico , Crnjac Andreo , Romano Francesco , Milluzzo Giuliana , Vignati Anna , Jakšic Milko , Calcagno Lucia , Camarda Massimo
Published: January 2023

Silicon carbide (SiC), thanks to its material properties similar to diamond and its industrial maturity close to silicon, represents an ideal candidate for several harsh-environment sensing applications, where sensors must withstand high particle irradiation and/or high operational temperatures. In this study, to explore the radiation tolerance of SiC sensors to multiple damaging processes, both at room and high temperature, we used the Ion Microprobe Chamber installed at the Ruđer Bošković Institute (Zagreb, Croatia), which made it possible to expose small areas within the same device to different ion beams, thus evaluating and comparing effects within a single device. The sensors tested, developed jointly by STLab and SenSiC, are PIN diodes with ultrathin free-standing membranes, realized by means of a recently developed doping-selective electrochemical etching. In this work, we report on the changes of the charge transport properties, specifically in terms of the charge collection efficiency (CCE), with respect to multiple localized proton irradiations, performed at both room temperature (RT) and 500 °C.
Wound Healing Properties of Natural Products: Mechanisms of Action
Authors: Criollo-Mendoza Marilyn S. , Contreras-Angulo Laura A. , Leyva-López Nayely , Gutiérrez-Grijalva Erick P. , Jiménez-Ortega Luis Alfonso , Heredia J. Basilio
Published: January 2023

A wound is the loss of the normal integrity, structure, and functions of the skin due to a physical, chemical, or mechanical agent. Wound repair consists of an orderly and complex process divided into four phases: coagulation, inflammation, proliferation, and remodeling. The potential of natural products in the treatment of wounds has been reported in numerous studies, emphasizing those with antioxidant, anti-inflammatory, and antimicrobial properties, e.g., alkaloids, saponins, terpenes, essential oils, and polyphenols from different plant sources, since these compounds can interact in the various stages of the wound healing process. This review addresses the most current in vitro and in vivo studies on the wound healing potential of natural products, as well as the main mechanisms involved in this activity. We observed sufficient evidence of the activity of these compounds in the treatment of wounds; however, we also found that there is no consensus on the effective concentrations in which the natural products exert this activity. For this reason, it is important to work on establishing optimal treatment doses, as well as an appropriate route of administration. In addition, more research should be carried out to discover the possible side effects and the behavior of natural products in clinical trials.
A Comprehensive Review on Bio-Based Materials for Chronic Diabetic Wounds
Authors: Pei Jinjin , Palanisamy Chella Perumal , Alugoju Phaniendra , Anthikapalli Naga Venkata Anusha , Natarajan Prabhu Manickam , Umapathy Vidhya Rekha , Swamikannu Bhuminathan , Jayaraman Selvaraj , Rajagopal Ponnulakshmi , Poompradub Sirilux
Published: January 2023

Globally, millions of people suffer from poor wound healing, which is associated with higher mortality rates and higher healthcare costs. There are several factors that can complicate the healing process of wounds, including inadequate conditions for cell migration, proliferation, and angiogenesis, microbial infections, and prolonged inflammatory responses. Current therapeutic methods have not yet been able to resolve several primary problems; therefore, their effectiveness is limited. As a result of their remarkable properties, bio-based materials have been demonstrated to have a significant impact on wound healing in recent years. In the wound microenvironment, bio-based materials can stimulate numerous cellular and molecular processes that may enhance healing by inhibiting the growth of pathogens, preventing inflammation, and stimulating angiogenesis, potentially converting a non-healing environment to an appropriately healing one. The aim of this present review article is to provide an overview of the mechanisms underlying wound healing and its pathophysiology. The development of bio-based nanomaterials for chronic diabetic wounds as well as novel methodologies for stimulating wound healing mechanisms are also discussed.
Alkyl 4-Aryl-6-amino-7- phenyl-3-(phenylimino)-4,7-dihydro- 3H-[1,2]dithiolo[3,4-b]pyridine-5-carboxylates: Synthesis and Agrochemical Studies
Authors: Dotsenko Victor V. , Sinotsko Anna E. , Strelkov Vladimir D. , Varzieva Ekaterina A. , Russkikh Alena A. , Levchenko Arina G. , Temerdashev Azamat Z. , Aksenov Nicolai A. , Aksenova Inna V.
Published: January 2023

The reaction between dithiomalondianilide (N,N’-diphenyldithiomalondiamide) and alkyl 3-aryl-2-cyanoacrylates in the presence of morpholine in the air atmosphere leads to the formation of alkyl 6-amino-4-aryl-7-phenyl-3-(phenylimino)-4,7-dihydro-3H-[1,2]dithiolo[3,4-b]- pyridine-5-carboxylates in 37–72% yields. The same compounds were prepared in 23–65% yields by ternary condensation of aromatic aldehydes, ethyl(methyl) cyanoacetate and dithiomalondianilide. The reaction mechanism is discussed. The structure of ethyl 6-amino-4-(4-methoxyphenyl)-7-phenyl-3-(phenylimino)-4,7-dihydro-3H-[1,2]dithiolo[3,4-b]pyridine-5-carboxylate was confirmed by X-ray crystallography. Two of the prepared compounds showed a moderate growth-stimulating effect on sunflower seedlings. Three of the new compounds were recognized as strong herbicide safeners with respect to herbicide 2,4-D in the laboratory and field experiments on sunflower.
Analysis of Intestinal Metabolites in SR−B1 Knockout Mice via Ultra−Performance Liquid Chromatography Quadrupole Time−of−Flight Mass Spectrometry
Authors: Chen Qijun , Wang Lixue , Chen Jinlong , Song Hui , Xing Wen , Wang Ziqian , Song Xueying , Yang Hua , Zhao Wenhua
Published: January 2023

Scavenger receptor class B type 1 (SR−B1), a multiligand membrane receptor, is expressed in a gradient along the gastrocolic axis. SR−B1 deficiency enhances lymphocyte proliferation and elevates inflammatory cytokine production in macrophages. However, whether SR−B1 affects intestinal metabolites is unclear. In this study, we detected metabolite changes in the intestinal tissue of SR−B1−/− mice, including amino acids and neurotransmitters, by ultra−performance liquid chromatography quadrupole time−of−flight mass spectrometry (UHPLC−Q−TOF/MS) and HPLC. We found that SR−B1−/− mice exhibited changes in intestinal lipid metabolites and metabolic pathways, including the glycerophospholipid, sphingolipid, linoleic acid, taurine, and hypotaurine metabolic pathways. SR−B1 deficiency influenced the contents of amino acids and neurotransmitters in all parts of the intestine; the contents of leucine (LEU), phenylalanine (PHE), tryptophan (TRP), and tyrosine (TYR) were affected in all parts of the intestine; and the contents of 3,4−dihydroxyphenylacetic acid (DOPAC) and dopamine (DA) were significantly decreased in both the colon and rectum. In summary, SR−B1 deficiency regulated intestinal lipids, amino acids, and neurotransmitter metabolism in mice.
Determination of Chemical Composition and Investigation of Biological Activities of Ocimum basilicum L.
Authors: Qasem Ahmed , Assaggaf Hamza , Mrabti Hanae Naceiri , Minshawi Faisal , Rajab Bodour S. , Attar Ammar A. , Alyamani Reema A. , Hamed Munerah , Mrabti Nidal Naceiri , Baaboua Aicha El , Omari Nasreddine El , Alshahrani Mohammed Merae , Awadh Ahmed Abdullah Al , Sheikh Ryan Adnan , Ming Long Chiau , Goh Khang Wen , Bouyahya Abdelhakim
Published: January 2023

This study aimed to determine the chemical composition of the essential oils (EOs) of Ocimum basilicum L., as well as to evaluate the antibacterial, antidiabetic, dermatoprotective, and anti-inflammatory properties, and the EOs and aqueous extracts of O. basilicum. The antibacterial activity was evaluated against bacterial strains, Gram-positive and Gram-negative, using the well diffusion and microdilution methods, whereas the antidiabetic activity was assessed in vitro using two enzymes involved in carbohydrate digestion, α-amylase and α-glucosidase. On the other hand, the dermatoprotective and anti-inflammatory activities were studied by testing tyrosinase and lipoxygenase inhibition activity, respectively. The results showed that the chemical composition of O. basilicum EO (OBEO) is dominated by methyl chavicol (86%) and trans-anethol (8%). OBEO exhibited significant antibacterial effects against Gram-negative and Gram-positive strains, demonstrated by considerable diameters of the inhibition zones and lower MIC and MBC values. In addition, OBEO exhibited significant inhibition of α-amylase (IC50 = 50.51 ± 0.32 μg/mL) and α-glucosidase (IC50 = 39.84 ± 1.2 μg/mL). Concerning the anti-inflammatory activity, OBEO significantly inhibited lipoxygenase activity (IC50 = 18.28 ± 0.03 μg/mL) compared to the aqueous extract (IC50 = 24.8 ± 0.01 μg/mL). Moreover, tyrosinase was considerably inhibited by OBEO (IC50 = 68.58 ± 0.03 μg/mL) compared to the aqueous extract (IC50 = 118.37 ± 0.05 μg/mL). The toxicological investigations revealed the safety of O. basilicum in acute and chronic toxicity. The finding of in silico analysis showed that methyl chavicol and trans-anethole (main compounds of OBEO) validate the pharmacokinetics of these compounds and decipher some antibacterial targets.
First Phytochemical Profiling and In-Vitro Antiprotozoal Activity of Essential Oil and Extract of Plagiochila porelloides
Authors: Pannequin Anaïs , Quetin-Leclercq Joëlle , Costa Jean , Tintaru Aura , Muselli Alain
Published: January 2023

Volatiles metabolites from the liverwort Plagiochila porelloides harvested in Corsica were investigated by chromatographic and spectroscopic methods. In addition to already reported constituents, three new compounds were isolated by preparative chromatography and their structures were elucidated by mass spectrometry (MS) and NMR experiments. Hence, an atypic aliphatic compound, named 1,2-dihydro-4,5-dehydronerolidol and two isomers, (E) and (Z), possessing an unusual humbertiane skeleton (called p-menth-1-en-3-[2-methylbut-1-enyl]-8-ol) are newly reported and fully characterized in this work. The in vitro antiprotozoal activity of essential oil and extract of P. porelloides against Trypanosoma brucei brucei and Leishmania mexicana mexicana and cytotoxicity were determined. Essential oil and Et2O extract showed a moderate activity against T. brucei with IC50 values: 2.03 and 5.18 μg/mL, respectively. It is noteworthy that only the essential oil showed a high selectivity (SI = 11.7). Diethyl oxide extract exhibited moderate anticancer (cancerous macrophage-like murine cells) activity and also cytotoxicity (human normal fibroblast) with IC50 values: 1.25 and 2.96 μg/mL, respectively.
Highly Sensitive ZnO/Au Nanosquare Arrays Electrode for Glucose Biosensing by Electrochemical and Optical Detection
Authors: Zulfa Vinda , Nasori Nasori , Farahdina Ulya , Firdhaus Miftakhul , Aziz Ihwanul , Suprihatin Hari , Rhomadhoni Muslikha , Rubiyanto Agus
Published: January 2023

The fabrication of a ZnO/Au nanosquare-array electrode was successfully carried out for the detection of glucose concentration in biomedical applications. The fabrication of the ZnO/Au nanosquare array using an ultra-thin alumina mask (UTAM) based on the imprinted anodic aluminum oxide (AAO) template and the direct current (DC) sputtering method was able to produce a very well-ordered nanosquare arrangement with a side size of 300 nm and a thickness of 100 nm. Tests were done to evaluate the performance of the electrode by means of cyclic voltammetry (CV) which showed that the addition of glucose oxidase (GOx) increased the sensitivity of the electrode up to 1180 ± 116 μA mM−1cm−2, compared with its sensitivity prior to the addition of GOx of 188.34 ± 18.70 mA mM−1 cm−2. A iox/ired ratio equal to ~1 between the peaks of redox reactions was obtained for high (hyperglycemia), normal, and low (hypoglycemia) levels of glucose. The ZnO/Au nanosquare-array electrode was 7.54% more sensitive than the ZnO/Au thin-film electrode. Furthermore, finite-difference time-domain (FDTD) simulations and theoretical calculations of the energy density of the electric and magnetic fields produced by the ZnO/Au electrode were carried out and compared to the results of CV. From the results of CV, FDTD simulation, and theoretical calculations, it was confirmed that the ZnO/Au nanosquare array possessed a significant optical absorption and that the quantum effect from the nanosquare array resulted in a higher sensitivity than the thin film.
Recent Advances in Asymmetric Catalysis Associated with B(C6F5)3
Authors: Zhan Ziye , Yan Jiale , Yu Zhiyou , Shi Lei
Published: January 2023

The prevalence and significance of asymmetric catalysis in the modern medicinal industry has been witnessed in recent years, which have already been used to manufacture the (S)-Naproxen and the (S)-Propranolol. With matched specificities such as the Lewis acidity and steric bulk, B(C6F5)3 has gained accelerating attention on its application in asymmetric catalysis of Diels–Alder cycloaddition reactions, carbonyl-ene cyclization, and other various reactions, which have been demonstrated by the elegant examples from the most recent literature. Some significant progress in the reaction of indirect activation of substrates through in situ generation of numerous supramolecular catalysts from B(C6F5)3 based on Lewis-acid-assisted Lewis acid (LLA) or Lewis acid assisted Brønsted acid (LBA) strategies or the reaction promoted by cooperative actions of chiral co-catalysts and B(C6F5)3 which played a direct role on the activation of substrates have been demonstrated in this review.
Enhanced Intracellular Photosensitizer Uptake and Retention by Targeting Viral Oncoproteins in Human Papillomavirus Infected Cancer Cells and Cancer Stem Cells
Authors: Chizenga Elvin Peter , Abrahamse Heidi
Published: January 2023

Immunogenic proteins in cancer are relevant targets for drug delivery. In Photodynamic Therapy (PDT), surface antigens have previously been used to deliver the photosensitizer (PS) to the tumor microenvironment for specific targeting. However, can we target intracellular antigens to achieve more than surface recognition? Can we possibly increase PS intracellular localization and prevent drug efflux at the same time? In this study, these questions were addressed by using a compound that can not only specifically recognize and bind to intracellular E6 oncoproteins in Human Papillomavirus (HPV)-Transformed cancer cells, but is also capable of enhancing transmembrane uptake using the cells’ own active transport mechanisms. HPV-transformed SiHa cells were cultured in vitro, and the resistant subpopulation was isolated using Magnetic Activated Cell Sorting (MACS). PDT was performed on four different cell types with varying physiognomies in terms of HPV oncoprotein expression and physiological form. Results demonstrated that tagging PSs on a carrier molecule that specifically delivers the PS inside the cells that express the target proteins enhanced both cellular uptake and retention of the PS even in the presence of drug efflux proteins on resistant subpopulations. These findings provide insight into the possibility of preventing cell-mediated resistance to PDT.
Effective Removal of Metal ion and Organic Compounds by Non-Functionalized rGO
Authors: Sarmiento Viviana , Lockett Malcolm , Sumbarda-Ramos Emigdia Guadalupe , Vázquez-Mena Oscar
Published: January 2023

Effective removal of heavy metals from water is critical for environmental safety and public health. This work presents a reduced graphene oxide (rGO) obtained simply by using gallic acid and sodium ascorbate, without any high thermal process or complex functionalization, for effective removal of heavy metals. FTIR and Raman analysis show the effective conversion of graphene oxide (GO) into rGO and a large presence of defects in rGO. Nitrogen adsorption isotherms show a specific surface area of 83.5 m2/g. We also measure the zeta-potential of the material showing a value of −52 mV, which is lower compared to the −32 mV of GO. We use our rGO to test adsorption of several ion metals (Ag (I), Cu (II), Fe (II), Mn (II), and Pb(II)), and two organic contaminants, methylene blue and hydroquinone. In general, our rGO shows strong adsorption capacity of metals and methylene blue, with adsorption capacity of qmax = 243.9 mg/g for Pb(II), which is higher than several previous reports on non-functionalized rGO. Our adsorption capacity is still lower compared to functionalized graphene oxide compounds, such as chitosan, but at the expense of more complex synthesis. To prove the effectiveness of our rGO, we show cleaning of waste water from a paper photography processing operation that contains large residual amounts of hydroquinone, sulfites, and AgBr. We achieve 100% contaminants removal for 20% contaminant concentration and 63% removal for 60% contaminant concentration. Our work shows that our simple synthesis of rGO can be a simple and low-cost route to clean residual waters, especially in disadvantaged communities with low economical resources and limited manufacturing infrastructure.