Abstract A021: Prevalence of metabolic syndrome and its association with physical activity in African American prostate cancer survivors at baseline of Men Moving Forward, a lifestyle intervention program
Authors: Gebreegziabher Meheret B. , Sheean Patricia , Papanek Paula , Vistcky Alexis , Iwalola Awoyinka , Banerjee Anjishnu , Uhrich Toni , Tovar Margaret , Powell Miracle , Contreras Sandra , O'Connell Kathleen , Stolley Melinda 
Published: December 2023

Background: Black/African American (Bl/AA) men have the highest death rate from Prostate Cancer(PC) compared to any other race/ethnicity. PC is also the second leading cause of death in this population. Men Moving Forward (MMF) is the first community-based lifestyle intervention developed with and for African American Prostate Cancer Survivors (AAPCS). This study assesses the prevalence of Metabolic Syndrome(MetS) in MMF cohort at baseline and explores the association between physical activity (PA) and MetS. MetS is implicated as a possible risk factor for the progression of PC and is a well-established risk factor for Cardiovascular (CV) disease, the most common cause of death among PC survivors cured of their cancers. MetS is defined as having three or more risk factors: waist circumference &gt; 40-inches, blood pressure (BP) &gt; 130/80 mmHg, fasting blood glucose &gt;100 mg/dl, HDL level &lt;40mg/dl and triglyceride level &gt; 150 mg/dl. Notably, physical inactivity is a known risk for MetS, CV disease and PC. Methods: MMF is a 16-week group-based lifestyle intervention, led by local health coaches. To be eligible, men must have a BMI &gt; 23 kg/m2, completed treatment or on active surveillance, and non-adherent to ACS nutrition OR PA guidelines. Men complete surveys, physical assessments, and blood draws at baseline, post-intervention, and 12-months. Baseline waist circumference, resting BP measurement, fasting glucose level, HDL level, and triglyceride level were examined. PA was measured using the Godin Leisure-Time Exercise scale with scores stratified into three activity levels: insufficiently active (&lt; 14 ), moderately active(14-23), and active(&gt; 24). The association between PA and MetS was assessed using Chi-square test of independence. Results: 117 AAPCS were enrolled at baseline, with 98 having complete PA and MetS data. These participants had a mean age of 66.21 ± 7.378. Top comorbidities include hypertension (71%), obesity (51%), diabetes (31%), and hypercholesterolemia (48%). 36.27% of participants had MetS at baseline, higher than the prevalence observed in NHANES for Bl/AA men without cancer (16.7%). Many had risk factors for MetS: 27% had BP &gt;130/80 mmHg, 65% had fasting glucose levels &gt; 100mg/dl, 27% had HDL level &lt;40 mg/dl, 17% had triglyceride levels &gt; 150 mg/dl and 73% had waist circumference &gt; 101.6cm(40 inches). When assessing physical activity at baseline 39% were active, 28% were moderately active and 33% were insufficiently active. 41% of those with MetS were insufficiently active. PA and MetS were not significantly associated X2(2, N = 98) = 0.370, P = 0.833. However, among MetS components, PA was significantly associated with high BP, X2(2, N = 108) = 10.51, P = 0.0052. Conclusion: Data reflects the value of supporting AAPCS in lifestyle changes to increase PA and to improve the burden of CV disease and PC recurrence risk. Few efforts have addressed lifestyle among AAPCS, despite high PC prevalence. Future reports will examine other factors associated with MetS and prostate cancer such as dietary intake and body composition.

Citation Format: Meheret B. Gebreegziabher, Patricia Sheean, Paula Papanek, Alexis Vistcky, Awoyinka Iwalola, Anjishnu Banerjee, Toni Uhrich, Margaret Tovar, Miracle Powell, Sandra Contreras, Kathleen O'Connell, Melinda Stolley. Prevalence of metabolic syndrome and its association with physical activity in African American prostate cancer survivors at baseline of Men Moving Forward, a lifestyle intervention program [abstract]. In: Proceedings of the 16th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2023 Sep 29-Oct 2;Orlando, FL. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2023;32(12 Suppl):Abstract nr A021.