bluuebunny/crossref_metadata_2025 huggingface dataset:
A rapid in vitro methodology for simultaneous target discovery and antibody generation against functional cell subpopulations
Authors: Nixon Allison M. L. , Duque Alejandro , Yelle Nicholas , McLaughlin Megan , Davoudi Sadegh , Pedley Nicolas M. , Haynes Jennifer , Brown Kevin R. , Pan James , Hart Traver , Gilbert Penney M. , Singh Sheila K. , O’Brien Catherine A. , Sidhu Sachdev S. , Moffat Jason
Published: January 2019

Cell surface antigen discovery is of great interest for biomedical research both for isolation of rare cell populations and therapeutic targeting. We developed a rapid, cost-effective, fully in vitro technology which facilities the simultaneous target discovery and human antibody generation on the surface of virtually any cell population of interest. We apply our technique to human colorectal cancer-initiating cells (CICs) and identify hundreds of unique human antibodies. We characterized the top three antibody candidates targeting these CICs and identify their protein targets as integrin α7 (ITGA7), HLA-A1 and integrin β6 (ITGB6). We demonstrate that these antibodies can be used to isolate self-renewing colorectal CICs, and that the integrin α7 antibody can prospectively identify glioblastoma brain tumor initiating cells as well as human muscle stem cells. We also demonstrate that genetic ablation of integrin β6 impedes colorectal CIC function. The methodology can be readily applied to other cell populations including stem cells, cancer, or immune cells to facilitate the rapid identification of novel targets and simultaneous generation of potent and specific antibodies with therapeutic potential.
Periodontal Regeneration by Allogeneic Transplantation of Adipose Tissue Derived Multi-Lineage Progenitor Stem Cells in vivo
Authors: Venkataiah Venkata Suresh , Handa Keisuke , Njuguna Mary M. , Hasegawa Tatsuya , Maruyama Kentaro , Nemoto Eiji , Yamada Satoru , Sugawara Shunji , Lu Lu , Takedachi Masahide , Murakami Shinya , Okura Hanayuki , Matsuyama Akifumi , Saito Masahiro
Published: January 2019

The ultimate goal of periodontal disease treatment is the reorganization of functional tissue that can regenerate lost periodontal tissue. Regeneration of periodontal tissues is clinically possible by using autogenic transplantation of MSCs. However, autologous MSC transplantation is limited depending on age, systemic disease and tissue quality, thus precluding their clinical application. Therefore, we evaluated the efficacy of allogeneic transplantation of adipose-derived multi-lineage progenitor cells (ADMPC) in a micro-mini pig periodontal defect model. ADMPC were isolated from the greater omentum of micro-mini pigs, and flow cytometry analysis confirmed that the ADMPC expressed MSC markers, including CD44 and CD73. ADMPC exhibited osteogenic, adipogenic and periodontal ligament differentiation capacities in differentiation medium. ADMPC showed high expression of the immune suppressive factors GBP4 and IL1-RA upon treatment with a cytokine cocktail containing interferon-γ, tumor necrosis factor-α and interleukin-6. Allogeneic transplantation of ADMPC in a micro-mini pig periodontal defect model showed significant bone regeneration ability based on bone-morphometric analysis. Moreover, the regeneration ability of ADMPC by allogeneic transplantation was comparable to those of autologous transplantation by histological analysis. These results indicate that ADMPC have immune-modulation capability that can induce periodontal tissue regeneration by allogeneic transplantation.
Mechanism of carrier controllability with metal capping layer on amorphous oxide SiZnSnO semiconductor
Authors: Lee Byeong Hyeon , Sohn Ahrum , Kim Sangsig , Lee Sang Yeol
Published: January 2019

The change of electrical performance of amorphous SiZnSnO thin film transistors (a-SZTO TFTs) has been investigated depending on various metal capping layers on the channel layer by causing different contact property. It was confirmed that the change of electrical characteristics was sensitively dependent on the change of the capping layer materials on the same channel layer between the source/drain electrodes. This sensitive change in the electrical characteristics is mainly due to different work function of metal capping layer on the channel layer. The work function of each capping layer material has been analyzed and derived by using Kelvin probe force microscopy and compared with the energy bandgap of the SZTO layer. When the work function of the capping layer is larger than that of the channel layer, electrons are depleted from the channel layer to the capping layer. On the contrary, in the case of using a material having a work function smaller than that of the channel layer, the electrical characteristics were improved because electrons were injected into the channel layer. Based on depletion and injection mechanism caused by different contact barrier between metal capping layer and channel layer, NOT, NAND, and NOR logic circuits have been implemented simply by changing metal capping layer on the channel layer.
Prediction of violent reoffending in prisoners and individuals on probation: a Dutch validation study (OxRec)
Authors: Fazel Seena , Wolf Achim , Vazquez-Montes Maria D. L. A. , Fanshawe Thomas R.
Published: January 2019

Scalable and transparent methods for risk assessment are increasingly required in criminal justice to inform decisions about sentencing, release, parole, and probation. However, few such approaches exist and their validation in external settings is typically lacking. A total national sample of all offenders (9072 released from prisoners and 6329 individuals on probation) from 2011–2012 in the Netherlands were followed up for violent and any reoffending over 2 years. The sample was mostly male (n = 574 [6%] were female prisoners and n = 784 [12%] were female probationers), and median ages were 30 in the prison sample and 34 in those on probation. Predictors for a scalable risk assessment tool (OxRec) were extracted from a routinely collected dataset used by criminal justice agencies, and outcomes from official criminal registers. OxRec’s predictive performance in terms of discrimination and calibration was tested. Reoffending rates in the Dutch prisoner cohort were 16% for 2-year violent reoffending and 44% for 2-year any reoffending, with lower rates in the probation sample. Discrimination as measured by the c-index was moderate, at 0.68 (95% CI: 0.66–0.70) for 2-year violent reoffending in prisoners and between 0.65 and 0.68 for other outcomes and the probation sample. The model required recalibration, after which calibration performance was adequate (e.g. calibration in the large was 1.0 for all scenarios). A recalibrated model for OxRec can be used in the Netherlands for individuals released from prison and individuals on probation to stratify their risk of future violent and any reoffending. The approach that we outline can be considered for external validations of criminal justice and clinical risk models.
Detecting and Mapping Harmful Chemicals in Fruit and Vegetables Using Nanoparticle-Enhanced Laser-Induced Breakdown Spectroscopy
Authors: Zhao Xiande , Zhao Chunjiang , Du Xiaofan , Dong Daming
Published: January 2019

Residues of harmful chemicals in fruit and vegetables pose risks to human health. Ordinary laser-induced breakdown spectroscopy (LIBS) techniques are unsatisfactory for detecting harmful chemicals in fruit and vegetables. In this study, we applied metal nanoparticles to fruit and vegetables samples to improve the ability of LIBS to detect trace pesticide and heavy metal residues in the samples. The nanoparticle-enhanced LIBS technique gave pesticide residue detection limits for fruit and vegetables two orders of magnitude lower than achieved using standard LIBS and heavy metal detection limits markedly better than achieved using standard LIBS. We used the nanoparticle-enhanced LIBS technique to study the distributions of harmful chemicals in vegetable leaves. We found that heavy metals are distributed unevenly in edible plant leaves, the heavy metal concentrations being higher in the veins than in the mesophyll.
Strong correlation between optical properties and mechanism in deficiency of normalized self-assembly ZnO nanorods
Authors: Chang Feng-Ming , Brahma Sanjaya , Huang Jing-Heng , Wu Zong-Zhe , Lo Kuang-Yao
Published: January 2019

Although, post annealing is an efficient way to annihilate/restructure deficiencies in self-assembly (SA) ZnO nanorods (ZNRs), the detailed investigation about the surface properties of annealed SA-ZNRs is a long standing issue and the major discrepancy is mainly due to single step annealing. We demonstrate the strategic two step annealing process to create reliable structural configuration in SA-ZNRs during the first round of annealing at 800 °C in vacuum (VA process), and create intrinsic defects in the second step of annealing in oxygen rich atmosphere (OA process) to correlate the formation of the defects related to green/orange-red emission. SA-ZNRs annealed in VA-OA processes reveal positive correlations between the oxygen flow rate and formation of oxygen interstitials (Oi) and zinc vacancies (VZn). The OA-VA processes exhibit the relation of residual Oi and additional Vo. According to VA-OA and OA-VA processes, we propose that the green emission in ZnO annealed in oxygen poor/rich condition is mainly due to the formation of Vo/VZn and annealing at oxygen rich condition creates Oi that lead to strong orange-red emission. Rather than O1s, we propose a reliable method by considering the peak shift of Zn2p in XPS to inspect the ZnO matrix, which has good interdependence with the characteristics of PL.
Effect of sea-bottom elasticity on the propagation of acoustic–gravity waves from impacting objects
Authors: Kadri Usama
Published: January 2019

Recent analysis of data, recorded on March 8th 2014 at the Comprehensive Nuclear-Test-Ban Treaty Organisation’s hydroacoustic stations off Cape Leeuwin Western Australia, and at Diego Garcia, has led to the development of an inverse model for locating impacting objects on the sea surface. The model employs the phase velocity of acoustic–gravity waves that radiate during the impact, and only considers their propagation in the water layer. Here, we address a significant characteristic of acoustic–gravity waves: the ability to penetrate through the sea-bottom, which modifies the propagation speed and thus the arrival time of signals at the hydrophone station. Therefore, we revisit some signals that are associated with the missing Malaysian Aeroplane MH370, and illustrate the role of sea-bottom elasticity on determining impact locations.
Integrated transcriptomic and proteomic analyses of a molecular mechanism of radular teeth biomineralization in Cryptochiton stelleri
Authors: Nemoto Michiko , Ren Dongni , Herrera Steven , Pan Songqin , Tamura Takashi , Inagaki Kenji , Kisailus David
Published: January 2019

Many species of chiton are known to deposit magnetite (Fe3O4) within the cusps of their heavily mineralized and ultrahard radular teeth. Recently, much attention has been paid to the ultrastructural design and superior mechanical properties of these radular teeth, providing a promising model for the development of novel abrasion resistant materials. Here, we constructed de novo assembled transcripts from the radular tissue of C. stelleri that were used for transcriptome and proteome analysis. Transcriptomic analysis revealed that the top 20 most highly expressed transcripts in the non-mineralized teeth region include the transcripts encoding ferritin, while those in the mineralized teeth region contain a high proportion of mitochondrial respiratory chain proteins. Proteomic analysis identified 22 proteins that were specifically expressed in the mineralized cusp. These specific proteins include a novel protein that we term radular teeth matrix protein1 (RTMP1), globins, peroxidasins, antioxidant enzymes and a ferroxidase protein. This study reports the first de novo transcriptome assembly from C. stelleri, providing a broad overview of radular teeth mineralization. This new transcriptomic resource and the proteomic profiles of mineralized cusp are valuable for further investigation of the molecular mechanisms of radular teeth mineralization in chitons.
Future increase in extreme El Nino events under greenhouse warming increases Zika virus incidence in South America
Authors: Rao V. Brahmananda , Maneesha K. , Sravya Panangipalli , Franchito Sergio H. , Dasari Hariprasad , Gan Manoel A.
Published: January 2019

The Zika virus (ZIKV) was first found in Zika forest, Uganda in 1947. The disease appeared in the Americas, Northeast Brazil in May 2015. ZIKV propagated rapidly across the Americas and the World Health Organization (WHO) in February 2016 declared this as a public health emergency of international concern. The temperature conditions related to extreme El Niño of 2015–16 were exceptionally favorable for ZIKV spreading in South America. For the recent spreading of ZIKV, in Americas, Northeast Brazil was the starting point and it was associated with the extreme El Niño 2015–16. Paz and Semenza found that there is a striking overlap when the regions with extreme climatic conditions in 1 month are juxtaposed with the geographic distribution of ZIKV in subsequent months. They found that the unique climatic conditions generated by extreme El Niño of 2015–16 are congenial for the dispersal of ZIKV in the Americas. This is not a just coincidence and many authors noted that ZIKV vector Aedes aegypti is strongly dependent on surface climate conditions that occur during extreme El Niño events. Recently a study found that extreme El Niño events will double in future in response to greenhouse warming. Also it was discovered that the increase of extreme El Niño frequency will continue long after 1.5 °C warming stabilization. We analyze future extreme El Niño events along with associated surface temperatures and calculated the ZIKV quantitatively in future extreme El Niño events and found that large parts of South America are highly favorable for the spread of the disease.
Computed tomography data collection of the complete human mandible and valid clinical ground truth models
Authors: Wallner Jürgen , Mischak Irene , Jan Egger
Published: January 2019

Image-based algorithmic software segmentation is an increasingly important topic in many medical fields. Algorithmic segmentation is used for medical three-dimensional visualization, diagnosis or treatment support, especially in complex medical cases. However, accessible medical databases are limited, and valid medical ground truth databases for the evaluation of algorithms are rare and usually comprise only a few images. Inaccuracy or invalidity of medical ground truth data and image-based artefacts also limit the creation of such databases, which is especially relevant for CT data sets of the maxillomandibular complex. This contribution provides a unique and accessible data set of the complete mandible, including 20 valid ground truth segmentation models originating from 10 CT scans from clinical practice without artefacts or faulty slices. From each CT scan, two 3D ground truth models were created by clinical experts through independent manual slice-by-slice segmentation, and the models were statistically compared to prove their validity. These data could be used to conduct serial image studies of the human mandible, evaluating segmentation algorithms and developing adequate image tools.
Spectroscopic analysis reveals the effect of a single nucleotide bulge on G-quadruplex structures
Authors: Chan Chun-Yin , Umar Mubarak I. , Kwok Chun Kit
Published: January 2019

This work employs multiple spectroscopic assays to examine the effect of the position and identity of a single-nucleotide bulge on G-quadruplex (G4).
Realization of low dislocation density AlN on a small-coalescence-area nano-patterned sapphire substrate
Authors: Xu F. J. , Zhang L. S. , Xie N. , Wang M. X. , Sun Y. H. , Liu B. Y. , Ge W. K. , Wang X. Q. , Shen B.
Published: January 2019

Growth behaviors of AlN on hexagonal configuration hole-type and truncated-cone-pillar-type nano-patterned sapphire substrates (NPSSs) have been investigated.
Alcohol-solvothermal syntheses, crystal structures and photocatalytic properties of tin selenides with polyselenide ligands
Authors: Han Jingyu , Zhang Limei , Li Shufen , Zheng Wei , Jia Dingxian , Yuan Yaxian
Published: January 2019

New polyselenidostannates with Se22−or Se42−polyselenide ligands, [TM(en)3]Sn3Se6(Se2) (1–3), [Ni(en)3]Sn3Se7.5(4) and [TM(en)3][Sn(Se4)3] (5–8), were prepared by alcohol-solvothermal methods.
Insights into the ion-exchange properties of Zn(ii)-incorporated MOR zeolites for the capture of multivalent cations
Authors: Wang Bangda , Koike Natsume , Iyoki Kenta , Chaikittisilp Watcharop , Wang Yi , Wakihara Toru , Okubo Tatsuya
Published: January 2019

The ion exchange property of MOR zeolites for multivalent cations is improved in the presence of Zn(ii).
Analysis of the interfacial characteristics of BiVO4/metal oxide heterostructures and its implication on their junction properties
Authors: Hermans Yannick , Murcia-López Sebastián , Klein Andreas , van de Krol Roel , Andreu Teresa , Morante Joan Ramón , Toupance Thierry , Jaegermann Wolfram
Published: January 2019

Throughin situphotoelectron spectroscopy, the interface properties of BiVO4/NiO, BiVO4/CoOxand BiVO4/ITO were investigated.
Zn supported on titania-doped mesoporous silicate MCM-41 as efficient catalysts for acetylene hydration
Authors: Wang Qinqin , Zhu Mingyuan , Dai Bin , Zhang Jinli
Published: January 2019

A highly efficient grafting method to synthesise Ti-doped MCM-41 mesoporous supports and their respective Zn catalysts was investigated.
Heteroleptic cobalt(iii) acetylacetonato complexes with N-heterocyclic carbine-donating scorpionate ligands: synthesis, structural characterization and catalysis
Authors: Nishiura Toshiki , Takabatake Asako , Okutsu Mariko , Nakazawa Jun , Hikichi Shiro
Published: January 2019

A first structure-determined heteroleptic cobalt(iii) complex with the less hindered tris(carbene)borate works as a catalyst precursor for alkane oxidation.
Carbonate and phosphite encaged in frameworks constructed from square lanthanum aminopolycarboxylates and sodium chloride
Authors: Wang Si-Yuan , Gao Song , Dai Jun-Wei , Shi Yan-Ru , Dong Xin , Weng Wei-Zheng , Zhou Zhao-Hui
Published: January 2019

Lanthanum aminopolycarboxylates, Na12n[La(edta)L]4n·8nNaCl·4nH2O (1: L = HPO32−; 2: L = CO32−) and K12n[La(cdta)(CO3)]4n·35nH2O (3), with square structures were obtained. Carbonate 2 possesses 3.7 Å diameter holes that can adsorb a small amount of O2 or CO2 selectively.
Synergistic chemopreventive effect of allyl isothiocyanate and sulforaphane on non-small cell lung carcinoma cells
Authors: Rakariyatham Kanyasiri , Yang Xiao , Gao Zili , Song Mingyue , Han Yanhui , Chen Xianggui , Xiao Hang
Published: January 2019

Combination of allyl isothiocyanate and sulforaphane produced a synergistic inhibition on lung cancer cell growth.
A thermo-responsive polymer-tethered and Pd NP loaded UiO-66 NMOF for biphasic CB dechlorination
Authors: Yao Bing-Jian , Fu Qi-Juan , Li Ai-Xiang , Zhang Xiao-Man , Li Yan-An , Dong Yu-Bin
Published: January 2019

As a thermo-responsive MOF-based emulsifier, Pd@UiO-66-S-PNIPAM can highly promote the biphasic chlorobenzene dechlorination at the toluene–water interface at room temperature.
Valorization of native sugarcane bagasse lignin to bio-aromatic esters/monomers via a one pot oxidation–hydrogenation process
Authors: Tana Tana , Zhang Zhanying , Beltramini Jorge , Zhu Huaiyong , Ostrikov Kostya (Ken) , Bartley John , Doherty William
Published: January 2019

An oxidation–hydrogenation process using atmospheric O2 has been developed to convert native bagasse lignin into bio-aromatic esters in a single step.
Chemical-PDMS binding kinetics and implications for bioavailability in microfluidic devices
Authors: Auner Alexander W. , Tasneem Kazi M. , Markov Dmitry A. , McCawley Lisa J. , Hutson M. Shane
Published: January 2019

We measure chemical-PDMS binding for 19 chemicals, correlate binding with molecular properties, and use measured kinetics to model in-device bioavailability.
Rapid kill assessment of anN-arylated NH125 analogue against drug-resistant microorganisms
Authors: Abouelhassan Yasmeen , Zhang Peilan , Ding Yousong , Huigens III Robert W.
Published: January 2019

N-Arylated NH125 analogue1rapidly eradicates a diverse panel of drug-resistant bacteria and fungi (≥99.9% kill in 1 to 10 minutes).
Investigating the intracellular effects of hyperbranched polycation–DNA complexes on lung cancer cells using LC-MS-based metabolite profiling
Authors: Alazzo Ali , Al-Natour Mohammad Ahmad , Spriggs Keith , Stolnik Snjezana , Ghaemmaghami Amir , Kim Dong-Hyun , Alexander Cameron
Published: February 2019

A metabolomics approach is used to assess the molecular mechanisms underlying the effects of polycation gene delivery vectors on lung cancer cells.
Ultrasound activation of liposomes for enhanced ultrasound imaging and synergistic gas and sonodynamic cancer therapy
Authors: Lin Xiahui , Qiu Yuan , Song Liang , Chen Shan , Chen Xiaofeng , Huang Guoming , Song Jibin , Chen Xiaoyuan , Yang Huanghao
Published: February 2019

Ultrasound (US) imaging is widely applied in hospital and clinical settings due to its non-invasiveness, controllability, and high tissue-penetrating ability.
Synthesis and electrochromic properties of a graphene oxide/silicon dioxide/oligoaniline interpenetrating network composite
Authors: Zhou Yan , Liu Xincai , Jia Xiaoteng , Chao Danming
Published: January 2019

We report a graphene oxide/silicon dioxide/oligoaniline interpenetrating network composite film through a crosslinking reaction, which demonstrates good electrochromic performance.
Ruthenium nanoparticles supported on nitrogen-doped porous carbon as a highly efficient catalyst for hydrogen evolution from ammonia borane
Authors: Cui Zhenkai , Guo Yueping , Feng Zhishang , Xu Dan , Ma Jiantai
Published: January 2019

The two-dimensional magnetic NC-Fe materials were prepared and modified with Ru nanoparticles to form Ru/NC-Fe nanocatalyst with excellent catalytic activity for hydrogen evolution from ammonia borane.
Broadband optical waveguide modulators based on strongly coupled hybrid graphene and metal nanoribbons for near-infrared applications
Authors: Ye Longfang , Sui Kehan , Zhang Yong , Liu Qing Huo
Published: January 2019

We demonstrate a variety of high performance broadband optical waveguide modulators using strongly coupled hybrid graphene and metal nanoribbons for near-infrared applications.
Porous PdRh nanobowls: facile synthesis and activity for alkaline ethanol oxidation
Authors: Li Zhijuan , Chen Yifan , Fu Gengtao , Chen Yang , Sun Dongmei , Lee Jong-Min , Tang Yawen
Published: January 2019

A novel catalyst of porous PdRh nanobowls with open porosity has been developed by using urea as a guiding surfactant. Benefiting from the compositional and structural advantages, the newly developed PdPh NBs exhibits outstanding electrocatalytic activity for the EOR which might make them good anodic candidates for direct ethanol fuel cells.
Impact of dimensionality and confinement on the electronic properties of mercury chalcogenide nanocrystals
Authors: Gréboval Charlie , Izquierdo Eva , Livache Clément , Martinez Bertille , Dufour Marion , Goubet Nicolas , Moghaddam Nicolas , Qu Junling , Chu Audrey , Ramade Julien , Aubin Hervé , Cruguel Hervé , Silly Mathieu , Lhuillier Emmanuel , Ithurria Sandrine
Published: January 2019

Infrared spectra of CdTe, HgTe and HgTe/CdS nanoplatelets.
Enhanced reduction of polymerization-induced shrinkage stress via combination of radical ring opening and addition fragmentation chain transfer
Authors: Schoerpf Sebastian , Catel Yohann , Moszner Norbert , Gorsche Christian , Liska Robert
Published: January 2019

The combination of vinylcyclopropanes with an ester-activated vinyl sulfonate ester in a light-induced radical polymerization shows high reactivity accompanied by a significant increase in conversion and it leads to an enhanced reduction of polymerization-induced shrinkage stress.
Non-Gaussian, non-ergodic, and non-Fickian diffusion of tracers in mucin hydrogels
Authors: Cherstvy Andrey G. , Thapa Samudrajit , Wagner Caroline E. , Metzler Ralf
Published: January 2019

We study the passive anomalous diffusion of micron-sized tracers in hydrogels of mucin polymers.
Human blood platelets contract in perpendicular direction to shear flow
Authors: Hanke Jana , Ranke Christiane , Perego Eleonora , Köster Sarah
Published: January 2019

We study the spreading and contraction behavior of platelets in microfluidic flow.
Lanthanide anthracene complexes: slow magnetic relaxation and luminescence in DyIII, ErIII and YbIII based materials
Authors: Zou Qian , Huang Xin-Da , Liu Jing-Cui , Bao Song-Song , Zheng Li-Min
Published: January 2019

[Ln(depma)2(H2O)6]Cl3·xH2O·yCH3OH [Ln = Dy, Gd, Er, Yb; depma = 9-diethylphosphono-methylanthracene] show photoluminescence at room temperature, and all except the Gd analogue also show field-induced single ion magnet behavior at low temperature.
Correction: Developing near-infrared long-lasting phosphorescence of Yb3+ through a medium: insights into energy transfer in the novel material Zn1.98Li0.02P2O7:Yb3+
Authors: Li Huimin , Pang Ran , Zhang Su , Lv Lingling , Feng Jing , Jiang Lihong , Li Da , Li Chengyu , Zhang Hongjie
Published: January 2019

Correction for ‘Developing near-infrared long-lasting phosphorescence of Yb3+ through a medium: insights into energy transfer in the novel material Zn1.98Li0.02P2O7:Yb3+’ by Huimin Li et al., Dalton Trans., 2018, 47, 9814–9823.
Correction: 2,5-Furandicarboxylic acid as a linker for lanthanide coordination polymers: the role of heteroaromatic π–π stacking and hydrogen bonding
Authors: Kumar Manesh , Nawaz Sheikh Haq , Franconetti Antonio , Zaręba Jan K. , Sahoo Subash Chandra , Frontera Antonio
Published: January 2019

Correction for ‘2,5-Furandicarboxylic acid as a linker for lanthanide coordination polymers: the role of heteroaromatic π–π stacking and hydrogen bonding’ by Manesh Kumar et al., New J. Chem., 2019, DOI: 10.1039/c8nj05701j.
Versispiroketal A, an unusual tetracyclic bridged spiroketal from the sponge-associated fungus Aspergillus versicolor SCSIO 41013
Authors: Salendra Limbadri , Luo Xiaowei , Lin Xiuping , Wang Junfeng , Yang Bin , Zhou Xuefeng , Liu Yonghong
Published: January 2019

Versispiroketal A (1), an unprecedented 6/5/5/6 tetracyclic polyketide featuring a rarely encountered bridge-fused spiroketal skeleton, was isolated from the sponge-associated fungus Aspergillus versicolor SCSIO 41013.
Space-confined indicator displacement assay inside a metal–organic framework for fluorescence turn-on sensing
Authors: Yang Ning-Ning , Zhou Li-Jiao , Li Peng , Sui Qi , Gao En-Qing
Published: January 2019

Taking advantage of space-confined competing supramolecular interactions, the indicator displacement assay was performed within a recyclable MOF, which allows for fluorescence turn-on sensing with dramatically improved sensitivity and anti-interference
Acyl-CoA: cholesterol acyltransferases-2 gene polymorphism is associated with increased susceptibility to coronary artery disease in Uygur population in Xinjiang, China
Authors: Wang Yong-Tao , Maitusong Buamina , Ma Yi-Tong , Fu Zhen-Yan , Yang Yi-Ning , Ma Xiang , Li Xiao-Mei , Liu Fen , Chen Bang-Dang
Published: January 2019

Background: Acyl-CoA: cholesterol acyltransferases (ACAT) is the only enzyme that catalyzes the synthesis of cholesterol esters (CE) from free cholesterol and long-chain fatty acyl-CoA and plays a critical role in cellular cholesterol homeostasis. In the present study, our primary objective was to explore whether the single-nucleotide polymorphisms (SNPs) in ACAT-2 gene were associated with coronary artery disease (CAD) in Uygur subjects, in Xinjiang, China.

Methods: We designed a case–control study including 516 CAD patients and 318 age- and sex-matched control subjects. Using the improved multiplex ligation detection reaction (iMLDR) method, we genotyped two SNPs (rs28765985 and rs7308390) of ACAT-2 gene in all subjects.

Results: We found that the genotypes, the dominant model (CC + CT vs TT) and over-dominant model (CT vs CC + TT) of rs28765985 were significantly different between CAD patients and the controls (P=0.027, P=0.012 and P=0.035, respectively). The rs28765985 C allele was associated with a significantly elevated CAD risk [CC/CT vs TT: odds ratio (OR) = 1.48, 95% confidence interval (CI) = 1.02–2.16, P=0.04] after adjustment for confounders. The TC and LDL-C levels were significantly higher in rs28765985 CC/CT genotypes than that in TT genotypes (P<0.05).

Conclusions: Rs28765985 of ACAT-2 gene are associated with CAD in Uygur subjects. Subjects with CC/CT genotype or C allele of rs28765985 were associated with an increased risk of CAD.
Integrating Simulations Into Communication Sciences and Disorders Clinical Curriculum: Impact of Student Perceptions
Authors: Clinard Erin S. , Dudding Carol C.
Published: January 2019

Purpose

The purpose of this mixed methods study was to examine student perceptions of computer-based simulation and to identify components of the simulation experience that were valued by the students. The aim of this study was to inform the development of effective approaches to integrating simulation into the speech-language pathology graduate curriculum.

Method

Participants were 1st-year graduate students in a residential, speech-language pathology master's program (
N
= 29). A convergent-parallel mixed methods study situated in the pragmatic paradigm was conducted. Students completed a quantitative survey regarding educational practices and participated in focus groups regarding their experiences in a semester-long, simulated diagnostic clinical placement. These quantitative data and qualitative inquiry were analyzed and interpreted to explore the perceptions and attitudes of participants.

Results

In response to the research questions, integration of the qualitative and quantitative data resulted in 4 primary themes related to the perceived strengths and weaknesses of computer-based simulation diagnostic evaluations. These themes were (a) Communication, (b) Skill Practice, (c) Technology, and (d) Independent Learning. Through analysis, these themes connected to represent a spectrum of strengths and weaknesses of computer-based simulation diagnostic evaluations.

Conclusions

The results of this study have allowed researchers to establish a framework for understanding the learning process associated with computer-based simulation from the perspective of the graduate student. This framework is useful in integrating simulations into the communication sciences and disorders curriculum in a manner that is systematic and in agreement with best practices in the nursing and medical literature.
The Effects of Acoustic Variation on the Perception of Lexical Tone in Cantonese-Speaking Congenital Amusics
Authors: Shao Jing , Lau Rebecca Yick Man , Tang Phyllis Oi Ching , Zhang Caicai
Published: January 2019

Purpose

Congenital amusia is an inborn neurogenetic disorder of fine-grained pitch processing. This study attempted to pinpoint the impairment mechanism of speech processing in tonal language speakers with amusia. We designed a series of perception tasks aiming at selectively probing low-level pitch processing and relatively high-level phonological processing of lexical tones, with an aim to illuminate the deficiency mechanism underlying tone perception in amusia.

Method

Sixteen Cantonese-speaking amusics and 16 matched controls were tested on the effects of acoustic (talker/syllable) variations on the identification and discrimination of Cantonese tones in two conditions. In the low-variation condition, tones were always associated with the same talker or syllable; in the high-variation condition, tones were associated with either different talkers (with the syllable controlled) or different syllables (with the talker controlled).

Results

Largely similar results were obtained in talker and syllable variation conditions. Amusics exhibited overall poorer performance than controls in tone identification. Although amusics also demonstrated poorer performance in tone discrimination, the group difference was more obvious in low-variation conditions, where more acoustic constancy was provided. Besides, controls exhibited a greater increase in discrimination sensitivity from high- to low-variation conditions, implying a stronger benefit of acoustic constancy.

Conclusions

The findings suggested that amusics' lexical tone perception abilities, in terms of both low-level pitch processing and high-level phonological processing, as measured in low- and high-variation conditions, are impaired. Importantly, amusics were more impaired in taking advantage of low acoustic variation contexts and thus less efficiently sharpened their perception of tones when perceptual anchors in talker/syllable were provided, suggesting a possible “anchoring deficit” in congenital amusia.

Supplemental Material

https://doi.org/10.23641/asha.7616555
Low‐complexity minimax design of digital FIR filters utilising linear programming in BI‐DAC
Authors: Yang Xing , Wang Houjun , Liu Ke , Xiao Yindong
Published: January 2019

This Letter presented a new‐order optimal method for lowering the computational complexity of the traditional minimax design of digital finite impulse response (FIR) filter utilising linear programming (LP) in bandwidth interleaving digital‐to‐analogue converter (BI‐DAC). In this order optimal method, a one‐by‐one increasing method was presented to optimise all of digital FIR subfilters' orders in BI‐DAC so that these digital FIR subfilters' orders could be optimised to simultaneously satisfy all of given upper bounds of the distortion and aliasing errors. A design example was used to verify the effectiveness and low computational complexity of the presented low‐complexity minimax design utilising LP, and the simulation results were well‐pleasing.
Ripple base signal flow graph modelling of DC–DC switching converters
Authors: Abbasi Majid , Afifi Ahmad , Alizadeh Pahlavani Mohammad Reza
Published: January 2019

A new ripple base signal flow graph (R‐SFG) modelling method was proposed to accurately model and analyse a family of switching DC–DC converter. The performance of some DC–DC converters such as single‐inductor multi‐output converters is dependent on inductor current ripples. This makes the conventional modelling methods cannot fully predict the overall behaviour of converter. From this family and in this study, a single‐inductor dual‐output (SIDO) boost/boost converter has been modelled based on proposed R‐SFG method. The simplicity and systematic procedure presented in this work showed that the R‐SFG could be a good alternative for modelling switching converter with complicated structures and with high inductor current ripple. In the new R‐SFG method, the effects of inductor current ripple have been considered to develop the conventional signal flow graph modelling method. In this work, a comparative study between two modelling methods has been carried out in a SIDO converter. A step‐by‐step direct mathematical manipulation was used to calculate the DC–DC transfer function of SIDO converter. The experimental results were included to show the validity of the obtained models. The experimental results showed that the maximum R‐SFG modelling error was about 5% over the wide range of inductor current ripple.
Position measurement of linear motor mover based on image spectrum energy
Authors: Zhao Jing , Dou Shaokun , Zhao Jiwen , Jiang Xu , Pan Zhenbao , Wang Hui
Published: January 2019

When the image position measuring method is applied to mover position measurement of a linear motor, the selection of the target source image is crucial to measurement accuracy and anti‐interference capacity. In this study, the fence image is used as the original shooting surface, and different kinds of fence images are constructed according to their width standard deviation and grey gradient sum. First, the relationship between the fence image spectrum energy and the correlation of image pixels is analysed. Then the image spectrum energy is used to characterise the feature of fence images during screening to select an aperiodic fence image with a strong anti‐interference. Second, the phase singularity method is used to match the two images before and after displacement to obtain a sub‐pixel displacement value of two images. Finally, according to the system calibration coefficient, the actual displacement value of the linear motor mover is obtained. Experimental results show that the fence image screening from image spectrum energy exhibits more anti‐interference for the position measurement of the linear motor, and the measurement algorithm based on the phase singularity algorithm is more stable. The absolute error of displacement is <0.023 mm, and the relative error change within 0.054–0.862%.
The VMC Survey
Authors: Groenewegen M. A. T. , Cioni M.-R. L. , Girardi L. , de Grijs R. , Ivanov V. D. , Marconi M. , Muraveva T. , Ripepi V. , van Loon J. Th.
Published: January 2019

In this paper JKs-band data from the VISTA Magellanic Cloud (VMC) survey are used to investigate the tip of the red giant branch (TRGB) as a distance indicator. A linear fit to recent theoretical models is used as the basis for the absolute calibration which reads MKs = −4.196 − 2.013 (J − Ks), valid in the colour range 0.75 <  (J − Ks)< 1.3 mag and in the 2MASS system. The observed TRGB is found based on a classical first-order derivative filter and a second-order derivative filter applied to the binned luminosity function using the “sharpened” magnitude that takes the colour term into account. Extensive simulations are carried out to investigate any biases and errors in the derived distance modulus (DM). Based on these simulations criteria are established related to the number of stars per bin in the 0.5 mag range below the TRGB and related to the significance with which the peak in the filter response curve is determined such that the derived distances are unbiased. The DMs based on the second-order derivative filter are found to be more stable and are therefore adopted, although this requires twice as many stars per bin. Given the surface density of TRGB stars in the Magellanic Clouds (MCs), areas of ∼0.5 deg2 in the densest parts to ∼10 deg2 in the outskirts of the MCs need to be considered to obtain accurate and reliable values for the DMs. The TRGB method is applied to specific lines-of-sight where independent distance estimates exist, based on detached eclipsing binaries in the Large and Small Magellanic Clouds (LMC, SMC), classical Cepheids in the LMC, RR Lyrae stars in the SMC, and fields in the SMC where the star formation history (together with reddening and distance) has been derived from deep VMC data. The analysis shows that the theoretical calibration is consistent with the data, that the systematic error on the DM is approximately 0.045 mag (about evenly split between the theoretical calibration and the method), and that random errors of 0.015 mag are achievable. Reddening is an important element in deriving the distance: we derive mean DMs ranging from 18.92 mag (for a typical E(B − V) of 0.15 mag) to 19.07 mag (E(B − V)∼0.04 mag) for the SMC, and ranging from 18.48 mag (E(B − V)∼0.12 mag) to 18.57 mag (E(B − V)∼0.05 mag) for the LMC.
How planetary growth outperforms migration
Authors: Johansen Anders , Ida Shigeru , Brasser Ramon
Published: January 2019

Planetary migration is a major challenge for planet-formation theories. The speed of type-I migration is proportional to the mass of a protoplanet, while the final decade of growth of a pebble-accreting planetary core takes place at a rate that scales with the mass to the two-thirds power. This results in planetary growth tracks (i.e., the evolution of the mass of a protoplanet versus its distance from the star) that become increasingly horizontal (migration dominated) with the rising mass of the protoplanet. It has been shown recently that the migration torque on a protoplanet is reduced proportional to the relative height of the gas gap carved by the growing planet. Here we show from 1D simulations of planet–disc interaction that the mass at which a planet carves a 50% gap is approximately 2.3 times the pebble isolation mass. Our measurements of the pebble isolation mass from 1D simulations match published 3D results relatively well, except at very low viscosities (α < 10−3) where the 3D pebble isolation mass is significantly higher, possibly due to gap edge instabilities that are not captured in 1D. The pebble isolation mass demarks the transition from pebble accretion to gas accretion. Gas accretion to form gas-giant planets therefore takes place over a few astronomical units of migration after reaching first the pebble isolation mass and, shortly after, the 50% gap mass. Our results demonstrate how planetary growth can outperform migration both during core accretion and during gas accretion, even when the Stokes number of the pebbles is small, St ~ 0.01, and the pebble-to-gas flux ratio in the protoplanetary disc is in the nominal range of 0.01–0.02. We find that planetary growth is very rapid in the first million years of the protoplanetary disc and that the probability for forming gas-giant planets increases with the initial size of the protoplanetary disc and with decreasing turbulent diffusion.
Properties of the transient X-ray pulsar Swift J1816.7–1613 and its optical companion
Authors: Nabizadeh Armin , Tsygankov Sergey S. , Karasev Dmitrij I. , Mönkkönen Juhani , Lutovinov Alexander A. , Nagirner Dmitrij I. , Poutanen Juri
Published: January 2019

We present results of investigation of the poorly studied X-ray pulsar Swift J1816.7–1613 during its transition from the type I outburst to the quiescent state. Our studies are based on the data obtained from X-ray observatories Swift, NuSTAR, and Chandra alongside with the latest IR data from UKIDSS/GPS and Spitzer/GLIMPSE surveys. The aim of the work is to determine the parameters of the system, namely the strength of the neutron star magnetic field and the distance to the source, which are required for the interpretation of the source behaviour in the framework of physically motivated models. No cyclotron absorption line was detected in the broad-band energy spectrum. However, the timing analysis hints at the typical for the X-ray pulsars magnetic field from a few ×1011 to a few ×1012 G. We also estimated the type of the IR-companion as a B0-2e star located at a distance of 7–13 kpc.
Predicted MOND velocity dispersions for a catalog of ultra-diffuse galaxies in group environments
Authors: Müller Oliver , Famaey Benoit , Zhao Hongsheng
Published: January 2019

The possibility that ultra-diffuse galaxies are lacking dark matter has recently stimulated interest to check the validity of modified Newton dynamics (MOND) predictions on the scale of such galaxies. It has been shown that the external field effect (EFE) induced by the close-by galaxy can suppress the velocity dispersion of these systems, so that they appear almost dark matter free in the Newtonian context. Here, following up on this, we are making a priori predictions for the velocity dispersion of 22 ultra-diffuse galaxies in the nearby Universe. This sample can be used to test MOND and the EFE with future follow-up measurements. We have constructed a catalog of nearby ultra-diffuse galaxies in galaxy group environments, and set upper and lower limits for the possible velocity dispersion allowed in MOND, taking into account possible variations in the mass-to-light ratio of the dwarf and in the distance to the galaxy group. The prediction for the velocity dispersion is made as a function of the three dimensional separation of the dwarf to its host. In 17 out of 22 cases, the EFE plays a crucial role in the prediction.
Constituent quark models for hadronic systems
Authors: Ghalenovi Zahra
Published: February 2019

In this work we introduce two different potential models for hadronic systems such that the QCD concepts of the quark-quark and quark-antiquark interactions be satisfied. We present the simple methods to solve two- and three-body equation of meson and baryon systems respectively. The introduced models are studied in the relativistic and non-relativistic limits.
La distribution de l’électricité : atouts et contraintes liés au réseau européen
Authors: Percebois Jacques
Published: January 2019

Jusqu’à la fin des années 1990, ce sont des entreprises publiques ou privées dites « intégrées » qui produisaient, transportaient et distribuaient l’électricité dans les divers pays européens. Dans certains pays, comme l’Allemagne, il y avait plusieurs entreprises régionales ; dans d’autres pays une seule entreprise nationale en position de monopole, comme EDF en France. La Directive européenne de 1996 a mis fin aux monopoles de production et de fourniture d’électricité. Les réseaux de transport et de distribution, qui fonctionnent comme des « monopoles naturels », sont devenus des « infrastructures essentielles » ouvertes à tous les producteurs et fournisseurs, moyennant des péages d’accès fixés par une commission de régulation indépendante. Ces réseaux sont au coeur des débats actuels, dans un contexte où ils doivent absorber une part croissante d’énergies renouvelables et faire face au développement de l’autoconsommation.
Effect of IL-6 Receptor Blockade on Proprotein Convertase Subtilisin/Kexin Type-9 and Cholesterol Efflux Capacity in Rheumatoid Arthritis Patients
Authors: Ferraz-Amaro Iván , Hernández-Hernández María , Tejera-Segura Beatriz , Delgado-Frías Esmeralda , Macía-Díaz María , Machado Jose , Diaz-González Federico
Published: January 2019

The aim of the work was to examine whether abnormalities in the lipid profile that tocilizumab (TCZ), an anti-IL-6 receptor Ab, exerts in rheumatoid arthritis (RA) patients is related to changes in either proprotein convertase subtilisin/kexin-9 (PCSK9) serum concentrations or in serum cholesterol efflux capacity (CEC). TOCRIVAR is a one-year prospective clinical trial that analyzes the influence of TCZ on cardiovascular risk factors. Twenty-seven RA patients receiving TCZ (8 mg/kg IV/q4w) were assessed at baseline and weeks 12, 24, and 52. Disease activity indexes, adiposity composition, physical activity, serum CEC, PCSK9, and lipoproteins serum concentrations were assessed at every visit. Basal high-sensitivity C-reactive protein (hs-CRP) and disease activity were markedly reduced throughout one-year TCZ treatment. While initially total cholesterol and LDL cholesterol increased their plasma concentration, decreasing to basal afterwards, lipoprotein(a) was significantly lower than basal in all visits of the study. CEC increased after 24 week of treatment proportionally to hs-CRP reduction, and remained significantly higher after week 52 [median % change 32 (3–141), p=0.021]. Interestingly, variations in LDL cholesterol basal concentration along the one year of TCZ treatment correlated directly with changes of PCSK9 serum concentration (r=0.37, p=0.003). Basal abdominal adiposity, BMI, and physical activity remained stable during the study. Long-term TCZ-treated RA patients show an increment in CEC inversely proportional to hs-CRP reduction and changes in LDL cholesterol that might be explained, at least in part, by variations in PCSK9 plasma concentration. Overall, TCZ treatment produces a favorable qualitative net effect in terms of atherogenic implication in RA patients.