bluuebunny/crossref_metadata_2025 huggingface dataset:
KARAKTERISTIK FISIKOKIMIA DAN ANTIOKSIDAN KRIM LULUR KOMBINASI BUBUR RUMPUT LAUT MERAH (Eucheuma cottonii) DAN COKELAT (Sargassum sp.)
Authors: Nurjanah Nurjanah , Ramli Rahayu Listiana , Jacoeb Agoes Mardino , Seulalae Anggrei Viona
Published: January 2023

Rumput laut Eucheuma cottonii dan Sargassum sp. memiliki potensi sebagai bahan baku pembuatan krim lulur. Rumput laut ini mengandung senyawa bioaktif yang dapat dimanfaatkan sebagai sumber antioksidan serta hidrokoloid sebagai pengental. Penelitian ini bertujuan untuk menentukan rasio terbaik kombinasi bubur rumput laut Euchema cottonii dan Sargassum sp. sebagai bahan baku krim lulur melalui pengujian kadar air, pH, viskositas, dan aktivitas antioksidan.  Penelitian ini terdiri dari dua tahapan yaitu, preparasi bubur rumput laut dan pembuatan krim lulur menggunakan tiga perlakuan yaitu, kombinasi bubur rumput laut E. cottonii dan Sargassum sp 1:1, 1:2, dan 2:1. Analisis data menggunakan rancangan acak lengkap dengan uji non parametrik Kruskal Wallis. Pengujian dilakukan sebanyak dua kali ulangan. Hasil penelitian menunjukkan rasio bubur rumput laut terbaik pada kombinasi 1:1 dengan nilai IC50 sebesar 116,53 ppm; pH 6,64; viskositas 7.541,67 cP; dan kadar air 94,72%. Analisis fitokimia bubur rumput laut jenis E. cottonii mengandung alkaloid dan fenol hidroquinon, sedangkan jenis Sargassum sp. mengandung flavonoid, tanin, fenol hidroquinon, dan steroid. Karakteristik krim lulur dengan penambahan bubur rumput laut kombinasi 1:1memiliki nilai pH 6,64 serta nilai IC50 sebesar 284,41 ppm. Penerimaan panelis terhadap krim lulur dengan penambahan bubur rumput laut yaitu netral hingga suka.
PENILAIAN KESIAPAN UKM PRODUSEN MI BASAH DALAM MENERAPKAN SERTIFIKASI STANDAR NASIONAL INDONESIA (SNI) 2987 : 2015 (Studi Kasus: CV. ABC)
Authors: Susanto Danar Agus , Suef Mokhamad , Karningsih Putu Dana , Prasetya Bambang
Published: January 2023

Produk mi basah merupakan salah satu makanan yang banyak dikonsumsi oleh masyarakat di Indonesia. Besarnya pangsa pasar produk ini, memberikan persaingan usaha antar produsen semakin sengit, sehingga memerlukan tindakan pelaku usaha untuk meningkatkan daya saing produknya. Khusus untuk Usaha Kecil Menengah (UKM), persaingan ini lebih terasa karena terbatasnya akses keuangan dan teknologi, biaya produksi tidak efisien, terbatasnya keterampilan manajemen, penjualan, dan bahan baku. Peningkatan daya saing produk dapat dilakukan dengan penerapan dan sertifikasi Standar Nasional Indonesia (SNI) 2987: 2015. Tujuan penelitian ini adalah mengetahui kesiapan UKM produsen mie basah (CV. ABC) dalam sertifikasi SNI. Metode penilaian kesiapan UKM CV. ABC dalam menerapkan SNI 2987:2015 terbagi atas empat tahapan, yaitu merancang alat ukur (kuesioner), penilaian dengan kuesioner, identifikasi variabel kritis dan penyusunan usulan program untuk mengeliminir variabel kritis. Hasil penelitian menunjukkan bahwa kesiapan CV. ABC dalam sertifikasi SNI adalah sebesar 67,67%. Variabel teknis menjadi variabel kritis dalam sertifikasi SNI sehingga diperlukan rekomendasi atau usulan program kebijakan berupa pendampingan sertifikasi.
Miaolingian and Furongian environmental impacts on reef building and carbonate environments: a model for consideration
Authors: Cordie David
Published: January 2023

Situated between two prominent radiation events, the middle and late Cambrian is understudied due to its lack of rock record and complex marine geochemical record. The study of reef evolution during this interval has also received less focus than surrounding intervals because of the reduced role of metazoan framework builders, though microbial reefs are prevalent. However, the middle and late Cambrian can provide valuable insights into the environmental controls on early reef development. Using fossil occurrences from the Paleobiology Database, Paleoreef Database, and a review of the primary literature, this study attempts to provide context for the conditions that may have influenced reef development in the Miaolingian and Furongian. Marine dissolved oxygen levels are the primary driver of reef diversity during this period, but ocean acidity, temperature, marine regression, nutrient load, and lack of supporting deep-water habitats may all have impacted metazoan reefs during the middle and late Cambrian. A model is here proposed which suggests that metazoan reef abundances were low during the middle and late Cambrian because of initial surface water anoxia that caused the extinction of metazoan reef builders in the late-early Cambrian, followed by reduction of metazoans in reef environments due to deep water anoxia and marine regression. These inhibiting conditions were not necessarily concurrent but did collectively inhibit the growth of metazoan reefs until the Early Ordovician when more shelf space for new reef development occurred. This model provides a first step in exploration of these conditions during the middle and late Cambrian and for reef development in general.
Validating Instruments to Screen for Psychopathy in a Non-Institutionalized Population
Authors: Bulajic Theadora , Amu Nkiruka Olivia Marie , Ren Jinge , Berner Claire Elise , Fomina Daria , Shah Sagar , Yaurimo John , Ayodele Morolayo , Zinn Jonah , Golden Sam , McClelland Shelby , Perez Jennifer Marina , Lowe Pranav , Goltermann Amy , Hafezi Sahar , Egazarian Alexis , Yang Huidi , Tong Victoria , Tossavainen Dylan , Cranmer Lucy , Florentin Alon , Veldhoen Naud Jacob Zwier , Freda Jennifer , Devli Stephanie , Karim Amelia , Boirond Barbara Angie Clergé , Torres-Siclait Helena Julia , Ienner Garrett , Poinçot-Leopardi Andrea , Spivack Stephen , Wallisch Pascal
Published: January 2023

We wanted to validate commonly used instruments to measure psychopathic tendencies in a college student population. To do so, we administered both the “Dark Triad Dirty Dozen” and the "Levenson Self-Report Psychopathy scale" to a high-powered sample of college students. Participants also performed a social discounting task to measure generosity. We correlated all of these measures and found that both instruments correlate well and negatively with generosity. We take these findings to indicate that both instruments are valid measures of psychopathic tendencies in non-institutionalized populations.
Treatment outcomes of Veteran men in a comprehensive Dialectical Behavior Therapy program: characterizing sex differences in symptom trajectories
Authors: Schreiber Alison , Cawood Chelsea
Published: January 2023

Dialectical Behavior Therapy (DBT) is one of the primary psychosocial treatments for reducing suicidal behaviors and improving psychosocial outcomes among patients with borderline personality disorder (BPD) and has been shown to reduce BPD symptoms when delivered in a Veteran Affairs medical center setting. Despite evidence of similar rates of BPD in both men and women, the vast majority of treatment outcome research in BPD has focused on women. We sought to characterize sex differences in symptom trajectories among Veterans participating in a comprehensive DBT program. We found that Veteran men and women who entered the DBT program were diagnostically and demographically similar. Participants exhibited reductions in BPD symptoms and improvements in emotion regulation over the course of treatment. Moreover, Veteran men reported BPD symptom reductions that were not statistically inferior to those of Veteran women and exhibited a sharper reduction in these symptoms. This research provides support for the use of DBT as a psychosocial treatment for Veteran men with BPD symptoms.
Dialéctica de la moda. Razón y vestir en la sociedad contemporánea
Authors: Hernández Pérez Christian Saúl
Published: January 2023

Se presenta un análisis del fenómeno de la moda en la sociedad contemporánea, a la luz de algunas premisas propuestas por Marcuse en torno a la razón y a las necesidades. Se sugiere que la moda cubre una necesidad vital, el vestir, pero es necesario formular su término negativo.
Automated Name Selection for the Network Scale-Up Method
Authors: Fenoy Adrià , Bojanowski Michał , Lubbers Miranda Jessica
Published: January 2023

The distribution of the number of acquaintances among members of a society is a relevant feature of its social structure. Furthermore, the number of acquaintances (or “degree”) is used for estimating other societal features, such as the size of hard-to-count subpopulations or social cohesion. To estimate the degree, the Network Scale-Up Method (NSUM) asks survey respondents about the number of people they know with a set of first names for which name statistics are available. For this method to be precise, a set of names needs to be selected for the survey that jointly represent the population on a smaller scale in terms of relevant traits such as gender or age. Finding the optimal set of names is a combinatorial problem for which this paper provides a solution approach. The approach can serve other NSUM users, and can be applied to any population for which name statistics distributed over different categories are available. We empirically show that our approach successfully provides subsets of names replicating the population distribution for six countries with very different name statistics.
Documentation of Wild Leafy Vegetable Plants of Chitwan, Nepal
Authors: Das Manoj Kumar Lal
Published: January 2023

Wild leafy vegetables are an important source of carbohydrates, proteins, minerals and fibers. Local people of Chitwan rely on wild leafy vegetables. Knowledge of wild leafy vegetables is part of traditional practice. This paper revealed total 38 plant species belonging to 32 Genera under 30 families which are consumed by local inhabitants of Chitwan. Out of 38 plants species consumed as leafyvegetable, 26 taxa were herbs, 6 species are climbers, 5 plant species as to trees and only one was climbers. The harvesting season of leafy vegetables are variable. 15 leafy vegetables plants were harvested during rainy season, 8 spp. were harvested in summer season. 12 plant species were harvested throughout the year. Similarly; 32 plant species were used for vegetables; 3 spp. were used for spices.A few spp. was consumed as raw, pickle and topping purpose.
Functional and Conceptual Differences of Micro-credit and Microfinance in Nepal
Authors: Dhakal Chandra
Published: January 2023

The study analyzes the functional and conceptual differences between micro-credit and microfinance in Nepal. The main concern of this paper is to analyze the fundamental differences between the concept of microcredit and microfinance. Generally, it uses similar terminology; however, it has certain fundamental dissimilarity on a practical level. The main focus of this study is to analyze theoretically and conceptually differences the terms used in the field of economic development and poverty alleviation field. The study has been based on a qualitative research paradigm and only secondary sources of data were used for this study. Books, articles, thesis, dissertations, and reports were the main secondary source of data. Secondary information has collected through the library research method. Data were analyzed by using a simple paragraph description. The conclusion of this study has been drawn based on analysis and description.
Dysnatremia in Traumatic Brain Injury and its Association with Outcome
Authors: Bishokarma S. , Thapa U. , Thapa M. , Singh A. K. , Gurung S. , Aryal B. , Maharjan A. M. S. , Lakshmipathy G.
Published: January 2023

Background Traumatic brain injury on its own results in significant mortality and morbidity but it also contributes to complications that manifest as dysnatremia in the majority of cases.

Objective The objective of this study is to assess the association of hyponatremia and hypernatremia with the severity of traumatic brain injury and its impact on mortality.

 Method This is a retrospective, descriptive, and analytic study conducted during a 1-year period from March 2018 to March 2019. The study population was selected from the patients presenting to the emergency department with TBI in the Upendra Devkota Memorial National Institute of Neurological and Allied Sciences, Bansbari, Kathmandu, Nepal. All the patients that fulfilled the inclusion criteria of age were enrolled in the study. Patients with known renal disease due to the higher incidence of electrolyte disbalance were excluded. Association of outcome with hyponatremia and hypernatremia were sought using chi-square, fisher exact test and independent t test using SPSS ver 20.

Result Over a period of 1 year, 367 patients with traumatic brain injuries were treated in our hospital. Hyponatremia was seen among 55 patients (14.9%) and hypernatremia was seen among 22 patients (5.99%). The age range of patients included in the study was 16 to 87 with a mean age of 37.96 ± 16.512 years. The male to female ratio was calculated as 3.2:1. Mild, moderate, and severe head injuries were 286 (77.9%), 37 (10.1%), and 44 (12%) respectively. Surgical intervention was performed among 77(21%) individuals. Our series showed an association between the severity of traumatic brain injury and hyponatremia however didn’t show an association between the severity of traumatic brain injury and the development of hypernatremia.

Conclusion We concluded that the severity of head injury is associated with severity of hyponatremia but not with severity of hypernatremia. Similarly, a strong association existed between the severity of hypernatremia and outcome of patients. However, such association was not seen with hyponatremia.
Linguistic Interference in Reading Stroop Card
Authors: Upadhayay N. , Guragain S. , Khadka P.
Published: January 2023

Background The Stroop test is a gold-standard cognitive function test that assesses selective attention. There are discrepancies of having language interaction in bilingual individuals on stroop test.

Objective To assess selective attention of Nepalese in Nepali and English versions of stroop test and investigating gender differences in it.

Method The study includes male (n 33) and female (n 33) of age 20-40 years. Their first home language is Nepali. The comparison of congruent and incongruent reaction time (selective attention) between two test versions was analyzed by Paired t-test. Gender differences on selective attention were analyzed by Independent sample t-test. Data are expressed as mean ± SD, p < 0.05.

Result The congruent time in Nepali test (47.34 ± 9.23) was higher than English (42.21 ± 10.17) test. The selective attention in Nepali (113.11 ± 24.04) was significantly better (low latency) than English version (119.67 ± 28.81) of the test. Female outperformed male in selective attention on both the versions.

Conclusion Orthographically and phonologically dissimilar languages affect the reaction time of bilingual individuals. Nepali stroop test can be a valid tool in assessing selective attention on Nepalese population. Females outperform males on selective attention as assessed by stroop test.
Dhulikhel Hospital Checklist Protocol for Temporal Bone Computed Tomography Scan Analysis: How We Do It?
Authors: Shrestha B. L. , KC A.K. , Karmacharya S.
Published: January 2023

The temporal bone is very complicated anatomical structure. Any disease process within this structure mandates thorough anatomical knowledge of the corresponding structure. The High resolution computed tomography (HRCT) temporal bone is the best way to look inside this complex bone. The importance of knowledge about how to read and look inside the CT scan temporal bone lead us develop the Dhulikhel Hospital Check list protocol. This protocol will help aspiring otologist and otolaryngologist to read and know details about the underlying structures.
Survey of Location Sensing Techniques
Authors: Joshi Abhash
Published: January 2023

Location-based services (LBS) have wide applicability in areas like navigation, tracking, emergency services, gaming, persuasive applications etc. The core element of any LBS is its positioning technology. This paper reviews taxonomy of location sensing techniques. Then several location sensing techniques like Global positioning system, Visible light positioning, Cell-Id, Received signal strength, Image recognition and IP based geolocation is surveyed,summarized and classified. Finally, this paper identifies the similarity and differences in location sensing techniques, current research trends and also area for future study.
Classified Staff and the Implementation of Positive Behavior Interventions and Supports: A Case Study
Authors: Woodlee Devon , Ingle W. Kyle
Published: January 2023

Guided by normalization process theory, our qualitative case study explored classified staff members’ perceptions of their role in the implementation of School-Wide Positive Behavioral Interventions and Supports in schools within a large urban US school district. Analysis reveals that classified staff members’ gleaned knowledge of positive behavioral interventions and supports (PBIS) and their role in implementation haphazardly through the trickle-down of secondhand, informal information from certified staff (administrators and teachers). This practice limited staff members’ understanding of roles, tasks, and responsibilities in implementation (individual specification) and the shared understanding of PBIS (communal specification). To the extent that classified staff members were internalizing PBIS practices (e.g., positive reinforcement for meeting behavior expectations), informants described their use as commonsensical but not due to any formal training opportunities provided to them. District and school leaders triangulated this finding, describing classified staff members as integral to PBIS implementation but providing no explicit, purposeful, and consistent plans to include them. In terms of policy and practice implications, we recommend that schools and districts implementing PBIS or any other school- or district-wide initiative be inclusive and strategic, involving classified staff in their exploration of possible initiatives, decision-making, planning, training, and evaluation. Educational leaders who opt to exclude classified staff members formally in their districts and schools’ collective efforts to implement school-wide initiatives do not fully leverage valuable human resources.
Telerehabilitation Implementation: Perspectives from Physiotherapists Working in Complex Care
Authors: O’Neil Jennifer , van Ierssel Jacquie , King Judy , Sveistrup Heidi
Published: January 2023

Purpose:

The COVID-19 pandemic resulted in a rapid change in ways clinicians deliver physiotherapy services, leading to an important uprise in telerehabilitation implementation. Sharing the experiences of physiotherapists in clinically adopting this technology during this initial wave of the pandemic can influence future implementation. This mixed-method study aimed to identify the barriers and new facilitators of telerehabilitation clinical implementation.

Method:

Canadian physiotherapists with and without telerehabilitation experience, working in various clinical settings, were recruited during the first wave of the COVID-19 pandemic. Participants completed the Assessing Determinants of Prospective Uptake of Virtual Reality instrument (ADOPT-VR) adapted for telerehabilitation and participated in online focus groups to explore their experiences with telerehabilitation implementation. Demographic data and ADOPT-VR responses were analyzed descriptively. Qualitative data were analyzed using content analysis.

Results:

Sixteen physiotherapists completed the study. Scores on the Likert scale showed that physiotherapists enjoyed telerehabilitation (7.5/10) and perceived it as being useful (7.3/10). Physiotherapists disagreed with the necessity to use only minimal mental efforts (4.4/10) and feeling familiar with the evidence (4.7/10). Limited access to telerehabilitation implementation evidence, a reduced hands-on approach, and a lack of validated remote assessments were reported as barriers. Clinical practice guidelines, validated remote neurological assessments, changes in physiotherapy curriculum, and policy-making are critical to improving telerehabilitation implementation within physiotherapy practices.

Conclusions:

Participants positively experienced the quick use of telerehabilitation from the beginning of the COVID-19 pandemic, but some important barriers remain.
COMPARATIVE ANALYSIS OF THE GEOTHERMAL POTENTIAL OF CLOSED MINES IN THE DONETSK AND RUHR COALMINING AREAS
Authors:   Dnipro University of Technology, Rudakov D. , Sun Yajun ,   China University of Mining and Technology, Sadovenko I. ,   Dnipro University of Technology, Inkin O. ,   Dnipro University of Technology
Published: January 2023

Purpose. This study aims to perform a comparative analysis of the geothermal potential for closed mines in the Donbas and Ruhr regions in terms of the operation efficiency of geothermal systems of various types. Methods. The proposed approach includes ranking closed mines in the Ruhr (Germany) and Donetsk (Ukraine) coalmining areas according to the major parameters of geothermal system efficiency that includes the maximum and net thermal capacity, heat pump coefficient of performance COP, energy efficiency of heat recovery. The last parameter, introduced by the authors earlier, is defined as the ratio of the produced thermal energy to the thermal equivalent of the electricity required for running the heat pumps and the heat transfer fluid circulation. Results. The average expected thermal capacity of open loop geothermal systems at mine drainages in Germany was found higher than the similar indicator for the selected mine drainages in Ukraine, with slightly lower indicators of mine water heat recovery compared to the drainages in the Donbas. The average expected thermal capacity of closed loop geothermal systems based on coaxial probes at the current water level in the mines of two areas is estimated to be within the range of 30-34 kW, and the average indicators of geothermal heat recovery in the mines of two areas differ by no more than 5%, while the mines in the Donbas demonstrate a higher dispersion of calculated indicators. Similarity of operating conditions and energy efficiency indicators of geothermal systems evaluated for two areas indicates the feasibility and the potential of operating such systems in Ukraine. Scientific novelty. The approach to ranking of closed mines according to their geothermal potential based on parameters of mine water heat recovery efficiency has been substantiated and implemented. The developed approach enables identifying the promising sites to install geothermal systems of various types at inactive mines. Practical significance. The proposed approach allows to preliminarily evaluate the ranges of indicators for the effective operation of geothermal systems of various types with identification of the most promising areas for further detailed technical and economic justifications.
ENSURING THE PROTECTION OF PEOPLE FROM EMERGENCIES RELATED TO FIRES IN BUILDINGS BELONGING TO CULTURAL HERITAGE OBJECTS
Authors:   Cherkasy Institute of Fire Safety named after Chornobyl Heroes of National University of Civil Defense of Ukraine, Cherkasy, Tsvirkun Serhii , Kostenko Tetiana ,   Cherkasy Institute of Fire Safety named after Chornobyl Heroes of National University of Civil Defense of Ukraine, Udovenko Maksym ,   Cherkasy Institute of Fire Safety named after Chornobyl Heroes of National University of Civil Defense of Ukraine
Published: January 2023

Purpose. Ensuring the protection of people from emergency situations related to fires in buildings belonging to cultural heritage sites by means of mathematical modeling of dynamic processes and phenomena characteristic of fire. Methods. The FDS software complex, which numerically solves the Navier-Stokes equation for low-speed temperature-dependent flows, was used to determine the dangerous factors of fire. An analytical model of the movement of people during a fire was used to calculate the evacuation time. Results. Based on the results of the simulation, the values of fire hazard factors in the volume of the building have been calculated, and the dependence of the indicators on time has also been determined. The obtained data illustrate the spread of dangerous fire factors in premises with a complex planning scheme. They are necessary for the rational placement of people in order to increase their safety in the event of an emergency. Due to mathematical modeling, we get information about which security measures should be given special attention. Scientific novelty of the obtained results lies in the fact that for the conditions of precisely such parameters of the volume-planning decisions of the building, the time of the onset of the critical value of dangerous fire factors and the time of evacuation of people from the premises have been determined. Practical significance of the obtained results lies in the possibility of using the principles and approaches presented in the work for similar cultural heritage sites to determine the necessary evacuation time, which allows increasing the safety of visitors and staff during an emergency situation. In this type of premises, special emphasis should be placed on equipping with visual indicators of evacuation routes.
İHRACAT İŞLEMLERİNDEN ELDE EDİLEN DÖVİZ GELİRİNİN ZORUNLU SATIŞI VE REESKONT KREDİSİ KULLANIMININ MUHASEBELEŞTİRİLMESİ
Authors: ESKİ Sulhi
Published: January 2023

İhracat işlemleri sonucu elde edilen gelir bir ülkenin en önemli ekonomik katma değeridir. İhracat ödemeler dengesinin sağlanmasının ve cari açığın kapatılmasının da önemli bir aracıdır. Tüm dünyayı etkileyen ekonomik durgunluk ve kriz Türkiye’yi de etkilemektedir. Türkiye ekonomisinde özellikle dış ticaret açığının, enerji dar boğazının ve cari açığın getirdiği sorunları giderebilmek için bir takım önlemler alınmıştır. Bu önlemlerden bir tanesi de ihracat işlemlerinden elde edilen dövizin Türkiye’ ye getirilmesi ve getirilen döviz miktarının belirli bir kısmının Türkiye Cumhuriyeti Merkez Bankasına (TCMB) satılması zorunluluğudur. Uygulamada ihracat işlemlerinden elde edilen dövizin belirlenen bir oran dahilinde diğer bir bankaya satılması bunun karşılığında ihracat reeskont kredisi kullanılması da mevcuttur. Bir takım sorunları da beraberinde getiren bu uygulamaların işletmeler açısından muhasebe kaydının yapılması da önem arz etmektedir. Çalışmanın amacı; işletmelerin gerçekleştirdiği ihracat işlemlerinin özellikle de zorunlu döviz satışı ve İhracat ve Döviz Kazandırıcı Hizmetler Reeskont Kredisi işlemlerinin muhasebe kayıtlarını gerçekleştirmektir. Çalışmanın yöntemi örnek muhasebe uygulamasıdır. Dış ticaret işlemlerinin önemli bir aşaması olan muhasebe kayıt işlemlerinin doğru olarak gerçekleştirilmesi işletmenin maddi ve hukuki kayıplarının önüne geçer. Muhasebe işlemleri ilgili mevzuatın uygulama sonuçlarının daha somut tespit edilmesini sağlar. Bu kapsamda; ihracattan elde edilen döviz gelirlerinin satışı TCMB döviz rezervlerine olumlu katkı sağlamaktadır. Ancak işletmeler açısından döviz satışının düşük kurdan döviz alışında yüksek kurdan yapılması finansal kayıplara yol açmaktadır. İhracat reeskont kredisinin kullanılması için ihracattan elde edilen döviz gelirinin TCMB’ye ve diğer bir bankaya satışı oranlarının yüksek olması ve ihtiyaç duyulan dövizin tekrar alınması halinde ilave maliyete katlanılmasına neden olmaktadır.
ADVANCED ALGORITHM OF EVOLUTION STRATEGIES OF COVARIATION MATRIX ADAPTATION
Authors: Litvinchuk Yu. , Malyk I.
Published: January 2023

The paper considers the extension of the CMA-ES algorithm using mixtures of distributions for finding optimal hyperparameters of neural networks. Hyperparameter optimization, formulated as the optimization of the black box objective function, which is a necessary condition for automation and high performance of machine learning approaches. CMA-ES is an efficient optimization algorithm without derivatives, one of the alternatives in the combination of hyperparameter optimization methods. The developed algorithm is based on the assumption of a multi-peak density distribution of the parameters of complex systems. Compared to other optimization methods, CMA-ES is computationally inexpensive and supports parallel computations. Research results show that CMA-ES can be competitive, especially in the concurrent assessment mode. However, a much broader and more detailed comparison is still needed, which will include more test tasks and various modifications, such as adding constraints. Based on the Monte Carlo method, it was shown that the new algorithm will improve the search for optimal hyperparameters by an average of 12%.
THE SET OF INCOMPLETE SUMS OF THE MODIFIED GUTHRIE-NYMANN SERIES
Authors: Pratsiovytyi M. , Karvatsky D.
Published: January 2023

In this paper we study topological and metric properties of the set of incomplete sums for positive series $\sum {a_k}$, where $a_{2n-1}=3/4^n+3/4^{in}$ and $a_{2n}=2/4^n+2/4^{in}$, $n \in N$. The series depends on positive integer parameter $i \geq 2$ and it is some perturbation of the known Guthrie-Nymann series. We prove that the set of incomplete sums of this series is a Cantorval (which is a specific union of a perfect nowhere dense set of zero Lebesgue measure and an infinite union of intervals), and its Lebesgue measure is given by formula: $\lambda(X^+_i)=1+\frac{1}{4^i-3}.$ The main idea of ??proving the theorem is based on the well-known Kakey theorem, the closedness of sets of incomplete sums of the series and the density of the set everywhere in a certain segment. The work provides a full justification of the facts for the case $i=2$. To justify the main facts, the ratio between the members and the remainders of the series is used. For $i=2$ we have $r_0=\sum {a_k}=2$, $a_{2n}-r_{2n}= \frac{1}{3} \cdot \frac{1}{4^n} + \frac{5}{3} \cdot \frac{1}{16^n}$ $r_{2n-1}-a_{2n-1}= \frac{2}{3} \cdot \frac{ 1}{4^n}-\frac{2}{3} \cdot \frac{1}{16^n}$. The relevance of the study of the object is dictated by the problems of the geometry of numerical series, fractal analysis and fractal geometry of one-dimensional objects and the theory of infinite Bernoulli convolutions, one of the problems of which is the problem of the singularity of the convolution of two singular distributions.
CONVOLUTION OF TWO SINGULAR DISTRIBUTIONS: CLASSIC CANTOR TYPE AND RANDOM VARIABLE WITH INDEPENDENT NINE DIGITS
Authors: Pratsiovytyi M. , Ratushniak S. , Symonenko Yu. , Shpytuk D.
Published: January 2023

We consider distribution of random variable $\xi=\tau+\eta$, where $\tau$ and $\eta$ independent random variables, moreover $\tau$ has classic Cantor type distribution and $\eta$ is a random variable with independent identically distributed digits of the nine-digit representation. With additional conditions for the distributions of the digits $\eta$, sufficient conditions for the singularity of the Cantor type of the distribution $\xi$ are specified. To substantiate the statements, a topological-metric analysis of the representation of numbers $x\in [0;2]$ in the numerical system with base $9$ and a seventeen-symbol alphabet (a set of numbers) is carried out. The geometry (positional and metric) of this representation is described by the properties of the corresponding cylindrical sets.
Determinants of Green Innovation Purchase Behaviour: An Emerging Country Perspective
Authors: Dilotsotlhe Nombulelo
Published: January 2023

The quantitative study reported in this article applied the diffusion of innovation theory (DOI) to predict the purchase intention for plug-in hybrid electric vehicles (PHEVs). Data were collected through an online survey involving 504 individuals in Gauteng, South Africa. The multiple regression technique was applied to the DOI model to test the proposed hypotheses of the study. Results indicate that relative advantage, compatibility and observability relate positively to PHEV purchase intention, while complexity is regarded as negative in that regard. On the other hand, trialability has no positive relation to PHEV purchase intention. The findings of this study can assist producers and marketers in crafting marketing strategies that can appeal to consumers and also increase their intention to purchase of plug-in hybrid electric vehicles.
A Comparative Study of Social Media Marketing and Conventional Marketing – A Case Study
Authors: Philomina Igbokwe Ify
Published: January 2023

This study examines the relationship between government expenditure and government revenue in Nigeria, covering the period 1981 to 2019. The Johansen technique and the VECX model were employed as econometric techniques of data analysis. This study confirms the existence of a positive long-run relationship between government expenditure and government revenue and that the expenditure elasticity of revenue is greater than unity thus confirming fiscal sustainability in Nigeria. The long-run relationship between government expenditure and government revenue is further shown in this study, how it determines the nature of the impact of deficit financing (debt) on the economy, and that expenditure elasticity below unity is not desirable. Further, the result of the VECX-based granger causality revealed that the spend-revenue hypothesis of Peacock & Wiseman (1961) holds for Nigeria's economy both in the short and long runs. The federal government of Nigeria is thus advised to set targets for revenue mobilization and utilization as well as devise a way of expenditure spreading over the entire economy.
Literature Review Faktor yang Mempengaruhi Pneumonia Aspirasi pada Pasien Stroke dengan Disfagia
Authors: Patmah Patmah , Mariana Evi Risa , Purwati Ningsih Endang Sri
Published: January 2023

Komplikasi penyakit stroke menjadi penyebab terbesar prevalensi kematian di suatu negara. Secara global sekitar 60% penderita stroke berisiko tinggi mengalami komplikasi seperti disfagia dan pneumonia aspirasi. Tujuan penelitian ini adalah untuk mengetahui lebih dalam lagi faktor yang mempengaruhi pneumonia aspirasi pada pasien stroke dengan disfagia melalui literatur. Dari pencarian literatur, terdapat 5 artikel yang memenuhi kriteria dari 3 database yaitu ScienceDirect, PubMed, dan Google Scholar. Protokol dan evaluasi literatur menggunakan JBI (Joanna Briggs Institute) Critical Appraisal Checklist.  Berdasarkan dari 5 artikel, didapatkan hasil analisis yaitu 3 faktor yang mempengaruhi. Pertama, faktor komorbiditas; infark miokard, gagal jantung kongestif, penyakit pembuluh darah perifer dan aneurisma, stroke iskemik, demensia, penyakit paru obstruktif kronis, Diabetes dengan kerusakan organ, serta tumor padat metastatik. Kedua, faktor jenis stroke iskemik (infark serebral dan leukoaraiosis (materi putih), dan yang ketiga faktor pemasangan alat medis khususnya nasogastric tube dalam jangka waktu yang lama. Diharapkan dari hasil penelitian literatur ini dapat lebih meningkatkan caring, pengetahuan tentang stroke yang berhubungan dengan pneumonia aspirasi dan disfagia oleh perawat yang difasilitasi oleh institusi pelayanan dan dipersiapkan oleh institusi pendidikan serta dari keluarga sebagai support system pasien.
The Immunohistochemical Study of Stathmin-1 as A Prognostic Factor In Non-small cell Lung Carcinoma
Authors: Wetwet Nadhema B. , Kerbel Hadeel A. , Baay Ali S. , Al-Obaidy Muhammed W.
Published: January 2023

الخلفيه:Stathmin1 المعروف أي ًضا باسم metablastin )هو بروتين رئيسي إلزالة البلمرة في األنابيب الدقيقة ، يشارك في تقدم دورة الخلية وحركةالخلية. تم العثور على Stathmin1 في بعض أنواع السرطان ومرتبط بتمايز الخاليا وتكاثرهاStathmin1 هو بروتين فسفوري خلوي رئيسي ينظم ديناميكيات األنابيب الدقيقة ويرتبط باألنماط الظاهرية الخبيثة في أنواع مختلفة من السرطان ، بمافي ذلك سرطان الرئة ذو الخاليا غير الصغيرة.المواد واألساليب :أجريت هذه الدراسة بأثر رجعي على عينات جراحية من الفورمالين مثبتة بالبارافين ألورام الرئة بتطبيق التقنياتالكيميائية الهيستولوجية المناعية باستخدام األجسام المضادة األولية لـ stathmin1 ، وإجراء التحليل اإلحصائي وتقييم االرتباط مع المعايير السريريةوالمرضية المختلفة المقاسة.النتائج :خمسون حالة من سرطانات الرئة غير الصغيرة التي تحتوي على 42 ٪سرطانة غدية ، و 44 ٪سرطان الخالياالحرشفيه، 10 ٪سرطان غدي متماثل و 4 ٪سرطان رئوي غير صغير ، 84 ٪كانت إيجابية 1-Stathmin ال يوجدكان مرتب ًط ارتباط كبير بين تعبير 1-Stathmin وعمر وجنس المرضى لكن تعبير 1-Stathmin ا بمعلمات بما في ذلك نوع ودرجة الورم. لوحظالتعبير العالي في األورام سيئة التمايز.االستنتاجات :قد يكون قياس مستوى ستاثمين 1 عالمة بيولوجية تنبؤية مفيدة ألورام الرئة غير الصغيرة ، خاصة األورام ضعيفةالتمايز.تعبير Stathmin1 في سرطان الرئة ذو الخاليا غير الصغيرة مرتبط بشكل كبير مع تمايز الورم الضعيف ويمكن. تنبؤياًمستقالاعتباره عاما
A short-term comparison between the effect of two different concentrations of methotrexate on ovarian tissues and function of female albino rats
Authors: Hussein Alak
Published: January 2023

Back ground: methotrexate is an antifolate that is widely used in cancers and inflammatory or auto- immune diseases, it is also known to be contraindicated in pregnancy, breast feeding and not recommended in patients planning to be parents since it has a harmful effect on fetus and gonads.
    Ovarian function can be evaluated by certain parameters like the levels of female hormones or anti- Mullerian hormone which is considered as a good indicator for this purpose or histopathological examination of ovarian follicles especially the primordial follicles.
  Objective: the aim of this study is to determine the effect of two different concentrations of methotrexate on ovarian tissue integrity and function.
  Materials and method: adult female albino rats (n=30) were randomly divided in to 3 groups; group A (n=10) in which animals were treated with i. p injection of normal saline once weekly for four weeks, group B (n=10) in which animals were treated with i. p. injection of 1mg/ kg bw of methotrexate once weekly for four weeks, and lastly group C in which animals were treated with i. p. injection of 2.5 mg/ kg bw of methotrexate once weekly for four weeks. Then serum level of anti- Mullerian hormone were measured and histopathological examination of the ovaries were done to evaluate ovarian injury caused by methotrexate treatment.
    Results: this study has demonstrated that methotrexate in the both 1mg and 2.5 mg / kg of BW doses did not significantly reduce the levels of anti- Mullerian hormone and the number of primordial follicles and atretic follicles were also not significantly affected by the treatment of methotrexate in both doses. While histopathological examination revealed mild ovarian damage in case of treatment with 1mg/ kg bw of methotrexate and moderate damage in case of treatment with 2.5 mg/ kg bw of methotrexate.
     Conclusions: there is no important difference between the effects of 1 and 2.5 mg/ kg of BW of methotrexate on ovarian function but there is a slight difference in the effects of the two different doses on the integrity of ovarian tissue.
تأثير عقار داباغليفلوزين على مستوى هيموجلوبين في الدم
Authors: A. Obeed Ahmed , A. AL-Kinani Tahseen , Ibrahim AL- Qadhi Huda
Published: January 2023

الخلفية: قصور القلب هو متلازمة إكلينيكية معقدة تنتج عن أي مرض قلبي وظيفي أو هيكلي يقلل من قدرة البطين على تعبئة الدم أو ضخه. فقر الدم شائع لدى مرضى قصور القلب ويرتبط بالتدهور من خلال تنشيط المسارات الهرمونية العصبية. عقار داباكليفلوزين  هو مثبط انتقائي وقابل للانعكاس للناقل المشترك للصوديوم الجلوكوز 2 (SGLT2). يزيد داباجليفلوزين من مستوى الهيموجلوبين من خلال آليات مختلفة مثل زيادة تركيز البلازما عن طريق إدرار البول أو زيادة تخليق الإريثروبويتين.
الهدف: تقييم تأثير الداباجليفلوزين الإضافي في العلاج التقليدي على الهيموجلوبين في مرضى قصور القلب المصابين بمرض الكلى المزمن (CKD) مع أو بدون داء السكري DM.
المرضى والطرق: كانت هذه دراسة سريرية مستقبلية أجريت في أجنحة طبية في مركز  الناصرية  للقلب خلال الفترة من 1 نوفمبر / 2021 إلى نهاية يوليو / 2022. تم إجراء البحث على 120 مشاركًا يعانون من قصور في القلب وضعف كلوي. تم تقسيم المرضى إلى مجموعتين. ضمت المجموعة الأولى 60 مريضاً تم إعطاؤهم داباجليفلوزين بالإضافة إلى الأدوية التقليدية ، وتألفت المجموعة الأخرى من 60 مريضاً تلقوا العلاج التقليدي فقط. تمت مطابقة كلا المجموعتين فيما يتعلق بالخصائص الاجتماعية والديموغرافية. تم تسجيل تركيز الهيموجلوبين في اليوم الأول كزيارة أساسية ثم تمت متابعتها بعد أربعة أشهر.
النتائج: قبل العلاج لم تكن هناك فروق ذات دلالة إحصائية في العوامل الاجتماعية والديموغرافية والسريرية بين المجموعتين. في مجموعة داباجليفلوزين ، كان مستوى الهيموجلوبين أعلى بكثير من مستوى ما قبل العلاج (12.53 جم / لتر مقابل 11.85 جم / لتر ، P = 0.016) ، كان لدى المرضى في المجموعة الضابطة مستوى متوسط ​​أقل بكثير من الهيموجلوبين بعد العلاج مقارنة بمستوى خط الأساس ( 11.88 جم / لتر مقابل 12.56 جم / لتر ، P = 0.001).
الاستنتاج: أظهرت الدراسة أن داباجليفلوزين يزيد تركيز الهيموجلوبين ويصحح  فقر الدم لدى مرضى قصور القلب المصابين بمرض الكلى المزمن مقارنة بمجموعة التحكم.
Intraindividual Cognitive Variability and Magnetic Resonance Imaging in Aging American Indians: Data from the Strong Heart Study
Authors: Mascarenhas Fonseca Luciana , Sage Chaytor Naomi , Olufadi Yunusa , Buchwald Dedra , Galvin James E. , Schmitter-Edgecombe Maureen , Suchy-Dicey Astrid
Published: January 2023

Background: American Indians have high prevalence of risk factors for Alzheimer’s disease and related dementias (ADRD) compared to the general population, yet dementia onset and frequency in this population are understudied. Intraindividual cognitive variability (IICV), a measure of variability in neuropsychological test performance within a person at a single timepoint, may be a novel, noninvasive biomarker of neurodegeneration and early dementia. Objective: To characterize the cross-sectional associations between IICV and hippocampal, total brain volume, and white matter disease measured by magnetic resonance imaging (MRI) among older American Indians. Methods: IICV measures for memory, executive function, and processing speed, and multidomain cognition were calculated for 746 American Indians (aged 64–95) who underwent MRI. Regression models were used to examine the associations of IICV score with hippocampal volume, total brain volume, and graded white matter disease, adjusting for age, sex, education, body mass index, intracranial volume, diabetes, stroke, hypertension, hypercholesterolemia, alcohol use, and smoking. Results: Higher memory IICV measure was associated with lower hippocampal volume (Beta = –0.076; 95% CI –0.499, –0.023; p = 0.031). After adjustment for Bonferroni or IICV mean scores in the same tests, the associations were no longer significant. No IICV measures were associated with white matter disease or total brain volume. Conclusion: These findings suggest that the IICV measures used in this research cannot be robustly associated with cross-sectional neuroimaging features; nonetheless, the results encourage future studies investigating the associations between IICV and other brain regions, as well as its utility in the prediction of neurodegeneration and dementia in American Indians.
Efficacy of Souvenaid® Combined with Acetylcholinesterase Inhibitors in the Treatment of Mild Alzheimer’s Disease
Authors: García-Alberca José María , Gris Esther , de la Guía Paz , Mendoza Silvia , de la Rica María López
Published: January 2023

Background: Souvenaid® is a medical food that contains nutrients that can help synapse synthesis in Alzheimer’s disease (AD). The potential effectiveness of combination therapy of Souvenaid with cholinesterase inhibitors (AChEI) is currently not well-known. Objective: To look into the effect of combination therapy with Souvenaid plus AChEI in people with mild AD in the real-world. Methods: We carried out a retrospective analysis in mild AD patients attending a memory clinic. Three groups were studied according to the treatment they received: Souvenaid alone (n = 66), AChEI alone (n = 84), and Souvenaid+AChEI (n = 70). Treatment effects were evaluated at baseline, 6 and 12 months. Cognitive functioning was assessed by Mini-Mental State Examination (MMSE), Rey Auditory Verbal Learning Test (RAVLT), Symbol Digit Modalities Test (SDMT), Boston Naming Test (BNT), Trail Making Test (TMT/A-B), Phonemic and Semantic Verbal Fluency Test (PVFT/SVFT); neuropsychiatric symptoms were evaluated by the Neuropsychiatric Inventory (NPI); functional capacity was assessed by the Bayer Activities Daily Living Scale (BAYER-S). A Mixed Model for Repeated Measures analysis was carried out to evaluate changes in outcome scores. Results: After 12 months Souvenaid+AChEI showed significant improvement in MMSE (p < 0.001), RAVLT (p < 0.0001), SVFT (p = 0.002), PVFT (p = 0.007), TMTA (p = 0.039), TMTB (p = 0.001), and NPI (p < 0.0001) compared to AChEI alone. Conclusion: Souvenaid showed cognitive and behavioral benefits in mild AD patients. These effects increased when Souvenaid and AChEI were used in combination. This study can serve as a model for the design of prospective controlled trials that help to support the combined use of Souvenaid and antidementia drugs in AD.
VCAM1 Drives Vascular Inflammation Leading to Continuous Cortical Neuronal Loss Following Chronic Cerebral Hypoperfusion
Authors: Sun Ruihua , Shang Junkui , Yan Xi , Zhao Jingran , Wang Wan , Wang Wenjing , Li Wei , Gao Chenhao , Wang Fengyu , Zhang Haohan , Wang Yanliang , Cao Huixia , Zhang Jiewen
Published: January 2023

Background: Chronic cerebral hypoperfusion (CCH) is associated with neuronal loss and blood-brain barrier (BBB) impairment in vascular dementia (VaD). However, the relationship and the molecular mechanisms between BBB dysfunction and neuronal loss remain elusive. Objective: We explored the reasons for neuron loss following CCH. Methods: Using permanent bilateral common carotid artery occlusion (2VO) rat model, we observed the pathological changes of cortical neurons and BBB in the sham group as well as rats 3d, 7d, 14d and 28d post 2VO. In order to further explore the factors influencing neuron loss following CCH with regard to cortical blood vessels, we extracted cortical brain microvessels at five time points for transcriptome sequencing. Finally, integrin receptor a4β1 (VLA-4) inhibitor was injected into the tail vein, and cortical neuron loss was detected again. Results: We found that cortical neuron loss following CCH is a continuous process, but damage to the BBB is acute and transient. Results of cortical microvessel transcriptome analysis showed that biological processes related to vascular inflammation mainly occurred in the chronic phase. Meanwhile, cell adhesion molecules, cytokine-cytokine receptor interaction were significantly changed at this phase. Among them, the adhesion molecule VCAM1 plays an important role. Using VLA-4 inhibitor to block VCAM1-VLA-4 interaction, cortical neuron damage was ameliorated at 14d post 2VO. Conclusion: Injury of the BBB may not be the main reason for persistent loss of cortical neurons following CCH. The continuous inflammatory response within blood vessels maybe an important factor in the continuous loss of cortical neurons following CCH.
Proliferation mechanism of collusive alienation in tendering for government investment projects
Authors: Chen Yun , Ma Chongsen , Ou Liang
Published: January 2023

Collusion between governments and enterprises has occurred in many economies around the world in the context of government investment projects and tenders. Not only is collusion an illegal act, but it may also lead to learning and imitation by non-colluding parties. Therefore, to control collusion and ensure the quality of government investment projects, investigating the spread of collusion in the bidding process of such projects is important. This study presents a simulation of the diffusion process of collusion among multiple entities through NetLogo, drawing on a contagious disease model. The effectiveness of the hypothesised control tools is validated through the changing trend of collusion in bidding in China. The findings provide a new approach to controlling collusion based on the perspective of the proliferation of bidding behaviour and have some reference value for the government to formulate policies.