bluuebunny/crossref_metadata_2025 huggingface dataset:
Combined effects of temperature, photoperiod, and salinity on reproduction of the brine shrimpArtemia sinica(Crustacea: Anostraca)
Authors: Yang Jing-Yu , Sun Shi-Chun
Published: September 2023

Background

Artemia sinicais a brine shrimp species distributed in hypersaline salt lakes in northern China and Siberia and a successful invasive species in some coastal salterns. Although it is a commercially harvested and cultured species, knowledge of its reproductive characteristics is limited, and existing studies are often contradictory. The combined effects of temperature, salinity, and photoperiod on reproduction characteristics are experimentally studied to better understand its reproductive features.

Methods

There were 36 combinations of three environmental factors (3 × 3 × 4), each with three or four levels, namely temperature (16, 25, 30 °C), photoperiod (6 L:18 D, 12 L:12D, 18 L:6D), and salinity (50, 100, 150, 200 PSU). In each treatment, 48 to 80 pairs ofA. sinicafrom Yuncheng Salt Lake (Shanxi, China) were cultured. Females were observed daily for reproductive mode and the number of offspring produced.

Results

Temperature, photoperiod, salinity, and their interactions significantly affected the lifespan and reproduction ofA. sinica.The reproductive period was the longest and accounted for the largest proportion of life span at moderate temperature (25 °C). Total offspring, offspring per brood, and offspring per day increased as salinity decreased, and the number of broods per female was highest at 25 °C. Temperature, photoperiod, and salinity significantly influenced reproductive modes, and interactions among these factors were identified.Artemia sinicaprimarily reproduces oviparously under low temperature and short daylight conditions, and ovoviviparously under high temperature and long daylight conditions, with the maximum oviparity ratio recorded in treatments of 16 °C, 6L:18D, and 50 or 100 PSU. The maximum ovoviviparity ratio was recorded under 30 °C, 12L:12D, and 100 PSU. Unlike that documented for otherArtemiaspecies or populations, the brood size ofA. sinicakept increasing throughout the reproductive period. It did not decline even in the last two broods. For the same brood number, the sizes of oviparous and ovoviviparous broods were similar. The length of the oviparous interval was often greater than that of the ovoviviparous interval, suggesting that oviparous offspring might require additional energy and time to construct the multi-layered eggshell. Compared to other species and populations, theA. sinicafrom Yuncheng Salt Lake has a relatively shorter pre-reproductive development time, a preference for ovoviviparity, and relatively higher fecundity and population growth capacity, making it a suitable culture species for obtaining fresh biomass.
Comparative analysis of codon usage patterns and phylogenetic implications of five mitochondrial genomes of the genus Japanagallia Ishihara, 1955 (Hemiptera, Cicadellidae, Megophthalminae)
Authors: Li Min , Wang Jiajia , Dai Renhuai , Smagghe Guy , Wang Xianyi , You Siying
Published: September 2023

Japanagallia is a genus of Cicadomorpha in the family of leafhoppers that are plant piercing-sucking insects, and it is difficult to distinguish by morphological characteristics. So far, only one complete mitochondrial genome data has been reported for the genus Japanagallia. Therefore, in order to better understand this group, we assembled and annotated the complete mitochondrial genomes of five Japanagallia species, and analyzed their codon usage patterns. Nucleotide composition analysis showed that AT content was higher than GC content, and the protein-coding sequences preferred to end with A/T at the third codon position. Relative synonymous codon usage analysis revealed most over-represented codon ends with A or T. Parity plot analysis revealed the codon usage bias of mitochondrial genes was influenced by both natural selection and mutation pressure. In the neutrality plot, the slopes of regression lines were < 0.5, suggesting that natural selection was playing a major role while mutation pressure was of minor importance. The effective number of codons showed that the codon usage bias between genes and genomes was low. Correspondence analysis revealed that the codon usage pattern differed among 13 protein-coding genes. Phylogenetic analyses based on three datasets using two methods (maximum likelihood and Bayesian inference), restored the Megophthalminae monophyly with high support values (bootstrap support values (BS) = 100, Bayesian posterior probability (PP) = 1). In the obtained topology, the seven Japanagallia species were clustered into a monophyletic group and formed a sister group with Durgade. In conclusion, our study can provide a reference for the future research on organism evolution, identification and phylogeny relationships of Japanagallia species.
Berberine protects hepatocyte from hypoxia/reoxygenation-induced injury through inhibiting circDNTTIP2
Authors: Zhu Yi , Li Junhui , Zhang Pengpeng , Peng Bo , Li Cai , Ming Yingzi , Liu Hong
Published: September 2023

Background

During hepatic ischemia-reperfusion injury, the excessive release of inflammatory cytokines can activate the intracellular signal transduction cascade to induce hepatocyte injury. Apoptosis is an important way of cell death after I/R injury. Berberine, a common quaternary ammonium alkaloid, has anti-inflammatory, anti-oxidative stress, and anti-apoptotic effects. An increasing number of studies have revealed the importance of non-coding RNAs, including microRNA, long non-coding RNAs and circular RNAs (circRNAs), as regulators of the effects of berberine.

Purpose

In this study, we investigated the mechanism of berberine against liver ischemia-reperfusion injury in vitro.

Study Design and Methods

In this study, hypoxia-reoxygenation (H/R)-treated L02 cells were pretreated with berberine to study the role and mechanism of berberine in resisting hepatic ischemia-reperfusion injury.

Results

The results show that berberine pre-treatment increased the cell viability of H/R-challenged cells, reduced H/R-induced apoptosis and ROS production, reversed H/R-increased on IL-6, IL-1β, TNF-α, and H/R-decreased IL-10 expression. Mechanically, berberine protect hepatocyte from H/R injury, at least partially, through circDNTTIP2. In addition, circDNTTIP2 can bind to the TATA box of caspase3 promoter, thereby promoting caspase 3-related cell apoptosis and the release of inflammatory cytokines.

Conclusion

This study found that berberine has a protective effect on H/R-induced hepatocyte damage by inhibiting a novel circRNA, circDNTTIP2. This study provides potential treatment strategies and treatment targets for liver ischemia-reperfusion injury.
Habitat suitability of four threatened Himalayan species: Asiatic black bear, common leopard, musk deer, and snow leopard
Authors: Malla Rajesh , Panthi Saroj , Adhikari Hari , Pariyar Shiva , Baral Rishi , Subedi Rukmagat , Adhikari Bishnu Prasad , Poudel Mahesh , Sedhai Nischal , Poudel Megharaj
Published: September 2023

Background

Biodiversity conservation is becoming challenging day by day. For this, it is essential to understand the distribution, habitat, and impact of anthropogenic activities on animals at risk. We assessed the suitable habitats and anthropogenic impacts on Asiatic black bears, common leopards, musk deer, and snow leopards in and outside the protected areas of Gandaki Province, Nepal.

Methods

We collected the presence locations of Asiatic black bears, common leopards, musk deer, and snow leopards based on scats and other signs. We employed the Maximum Entropy (MaxEnt) tool to identify suitable habitats of our studied species and their anthropogenic impacts on them.

Results

The total suitable habitat of the common leopard was found to be 6,052 km2, followed by the Asiatic black bear (5,819 km2), snow leopard (4,447 km2), and musk deer (1,690 km2) in Gandaki Province. Most of the areas of suitable habitat for common leopards and Asiatic black bears were outside the protected areas, and for musk deer and snow leopards were inside the protected areas. Elevation was the most important variable determining habitat suitability of Asiatic black bear, common leopard, and musk deer, whereas the distance to water was the most important variable determining habitat suitability of snow leopard. Asiatic black bears, common leopards, and musk deer face significant anthropogenic impacts, but snow leopards face some anthropogenic impacts.

Conclusion

Managing these animals’ habitats inside and outside protected areas is essential. Hence, biodiversity conservation and livelihood opportunities should be balanced in the Himalayas on a win-win basis.
Seroprevalence of SARS-CoV-2 anti-spike IgG antibody among COVID-19 vaccinated individuals residing in Surabaya, East Java, Indonesia
Authors: Megasari Ni Luh Ayu , Yamani Laura Navika , Juniastuti Juniastuti , Lusida Maria Inge , Mori Yasuko
Published: September 2023

Background

To limit the SARS-CoV-2 transmission, the Indonesian government launched a COVID-19 vaccination program in January 2021. Studies on the clinical treatment and implementation of COVID-19 vaccination have shown promising results; however, it is necessary to estimate the effectiveness of the vaccines. With the ongoing COVID-19 pandemic, studies have highlighted the impact of COVID-19 vaccines, especially CoronaVac, on Indonesian healthcare workers. To get a better picture of how the vaccines work in Indonesia, it is necessary to estimate the prevalence of SARS-CoV-2 anti-S IgG antibody induced by the COVID-19 vaccine in individuals who have already received two-to-three doses of vaccines.

Materials and Methods

Four-hundred and ninety-six whole-blood samples were collected from participants residing in Surabaya, East Java, Indonesia, who received a minimum of a two-dose COVID-19 vaccine. Serums were then isolated from the blood and subjected to detect SARS-CoV-2 anti-S IgG antibodies using a lateral flow immunochromatographic assay.

Results

The prevalence of positive anti-S-IgG antibodies was 91.7% (455/496) in all participants receiving a minimum of a two-dose COVID-19 vaccine. As many as 209 (85.3%) and 141 (96.6%) participants were seropositive for receiving CoronaVac and AstraZeneca, respectively. Meanwhile, all participants receiving two-dose CoronaVac with one booster dose of Moderna (105/100%) were seropositive (p < 0.05). Age, comorbidity, and time after the last vaccine were significantly correlated with seropositivity (p < 0.05).

Conclusion

Different vaccines might produce different antibody responses. Adopting a stronger policy regarding the administration of booster doses might be beneficial to elicit positive anti-S-IgG antibodies, especially among older individuals, those with comorbid diseases, and those with a longer time after the second vaccination dose.
Plan de formación docente de educadoras y técnicos en párvulos en ejercicio para la generación de aprendizajes de educación musical en los niveles de sala cuna menor y mayor
Authors:   ,   Pontificia Universidad Católica de Chile. Facultad de Educación, González Carrillo Nicole Alejandra
Published: September 2023

Existen estudios que señalan déficits en las formaciones iniciales de educadoras de párvulos en educación musical. Las Bases Curriculares de la Educación Parvularia les otorgan un amplio sentido a los lenguajes artísticos, por tanto, es importante indagar cómo se pueden establecer iniciativas para la promoción del desarrollo de habilidades musicales para los párvulos a través del desarrollo profesional docente. Se pretende diseñar un plan de formación continua para equipos pedagógicos en ejercicio, para sala cuna menor y mayor. A través del análisis documental y de contenido, se analizaron qué señalan las BCEP al respecto y cuál es el rol de la formación continua en el área. Los resultados destacan la discusión sobre: validación del personal técnico como protagónico en su rol educativo, la importancia de las formaciones docentes en educación musical como espacios necesarios para la reflexión pedagógica y el énfasis que debiese tener la educación musical en el referente curricular chileno como eje transversal para el desarrollo de la educación parvularia. Las contribuciones del estudio son el aporte al desarrollo curricular en educación musical infantil y al campo del desarrollo profesional en el nivel de educación parvularia, ofreciendo la discusión de su importancia y pertinencia curricular en salas cunas.
Curriculizando aprendizaje basado en proyectos: gestión curricular y aprendizaje basado en proyectos en un colegio particular subvencionado
Authors:   ,   Pontificia Universidad Católica de Chile. Facultad de Educación, González Valdés Camila A.
Published: September 2023

A pesar del reconocimiento que ha recibido en los últimos años y su inclusión en el currículum nacional, todavía no hay claridad sobre cómo la metodología activa ‘Aprendizaje Basado en Proyectos’ (ABP) puede transformarse en una experiencia formativa en la escuela a través de la gestión curricular. El presente estudio da cuenta de la toma de decisiones curriculares de los actores educativos en un colegio particular subvencionado para así fortalecer el diseño e implementación de los proyectos ABP. La metodología utilizada fue de estudio de caso, la cual consta de un análisis temático y FODA. El problema central del caso es la parcial integración del diseño e implementación de ABP en el colegio. Se propone brindar un equilibrio entre el control y la flexibilidad en la toma de las decisiones curriculares de los actores educativos en los niveles meso y micro a través de unas orientaciones de fortalecimiento curricular.
Reconfiguring Workspaces: Adaptations of Corporate Real Estate Design in the Context of the COVID-19 Pandemic and Economic Crisis in Sri Lanka
Authors: Kaluthanthri P. C. , Aluthgedara H. M. A. G. T. M.
Published: September 2023

Corporate Real Estate (CRE) pertains to the real estate assets utilized by businesses for their corporate operations. It serves as a conducive environment for accommodating staff, manufacturing and selling goods, and delivering services to customers. The COVID-19 pandemic has precipitated substantial changes in the utilization of office spaces by organizations. Prolonged lockdown measures and the adoption of remote work practices have resulted in the underutilization of office spaces across many organizations. Additionally, the aftermath of the pandemic has severely impacted the Sri Lankan economy, leading to decreased economic activities due to high inflation, import restrictions, and high finance rates. Consequently, organizations are compelled to modify their CRE environments to maximize its utilization which creates mixed views on its impact on financial and non-financial performance of the organization. Against this backdrop, the study examines the impact of modifications and adaptations in corporate real estate design on financial and non-financial performance of organizations. Total of 12 hypotheses were tested, exploring the association between changing organization structure, minimizing space requirement, workplace redesign, downsizing, work from home arrangement, and the utilization of co-working spaces, on financial and non-financial performance of the commercial real estates. The study population comprises executive employees involved in CRE decision-making within commercial real estates. A total of 164 respondents participated in a questionnaire survey, which was distributed online using convenience sampling techniques. The analysis employs Partial Least Squares Structural Equation Modeling (PLS-SEM) and adopts reflective constructs. This approach provides a robust conceptual framework for assessing the overall impact of changes in corporate real estate design on organizational performance. The findings of the study confirmed that changing organization structure, downsizing, work from home arrangements, have a significant positive impact on financial performances of commercial real estate. Moreover, minimizing space requirement, downsizing, work from home arrangements exhibit a positive significant relationship with the non-financial performances. The study's results provide insights into the relationship between decision-making on Corporate Real Estate (CRE) and its influence on the overall financial and non-financial performance of the commercial real estate. These findings assist top management in understanding the alignment required between future CRE strategic decisions and corporate performance.
Enhancing Chickpea (Cicer arietinum L.) Tolerance to Salinity through Plant Growth Regulators
Authors: Saif Hasib Bin , Mokarroma Nadira , Ruma Kanis Fatema , Islam Md. Amirul , Karim Md. Rezaul
Published: September 2023

During the period of 2020-21, a research study was carried out at the Plant Protective Culture Unit within the semi-controlled environmental settings of the Bangladesh Agricultural Research Institute. The aim of the study was to mitigate the negative impacts of salinity stress on chickpea by applying various concentrations of salicylic acid (SA) and gibberellic acid (GA3). Plants were subjected to four different levels of salinity stress, including a control group, mild stress, moderate stress, and severe stress. This was achieved by irrigating them with four varying concentrations of saline water (5, 7.5, 10 and 12.5 dSm-1) starting from the 14th day after sowing (DAS) and continuing until maturity at 100 DAS. On the other hand, the control plants received regular irrigation with tap water. Two concentrations of salicylic acid (SA) specifically 200 ppm and 400 ppm, along with gibberellic acid (GA3) at 10 ppm and 20 ppm, were administered as a foliar spray once a week, commencing at 20 days after sowing (DAS) and continuing until the flowering stage. Data related to chlorophyll levels in the leaves and water-related traits, including relative water content (RWC) and water retention capacity (WRC) were collected seven days after the foliar spray of these plant growth regulators at the flowering stage. Additionally, measurements of total dry weight, yield, and various yield-contributing factors were taken at the point of maturity. The results indicated that chickpea suffered adverse consequences due to salinity stress which included a reduction in chlorophyll content, a decrease in relative water content, a decline in water retention capacity, a decrease in total dry weight and a lower overall yield. However, the foliar application of different doses of salicylic acid (SA) and gibberellic acid (GA3) under varying levels of salinity stress had beneficial effects in alleviating the impact of salinity stress. Interestingly, it was observed that lower concentrations of SA at 200 ppm and GA3 at 10 ppm were more effective in mitigating the adverse effects of salinity stress and improving salinity tolerance in chickpea, especially under mild salinity stress conditions (5 dSm-1) as evidenced by the positive influence on the parameters mentioned above.
Potential of Ultrasound in Food Processing: An Overview
Authors: Darsana K.  , Sivakumar P.
Published: September 2023

Ultrasound is well known for its versatile processing in food industry. Ultrasound can be used in various unit operations such as filtration, freezing, thawing, brining, sterilization/pasteurization, and cutting, in different food divisions including meat, fruits and vegetables, cereals, and dairy. It serves as a sustainable and low-cost alternative to traditional heat-based technologies. Ultrasound technology has revolutionized the food processing industry by offering rapid processes, enhanced efficiency, improved shelf life. Application of ultrasound in food will serve the benefits in several manners like conserve the nutrients for ultimate customer, improve physico-chemical characters of food along with sensory characteristics and responsible for preservation of food through different mechanisms. In this review the major applications of ultrasonic technique during processing or as a pre-treatment show tremendous potential as a non-thermal technique are discussed briefly.
Influence of Weather Parameters on Incidence of Black Spot of Papaya Caused by Asperisporium caricae
Authors: Shreedevasena S. , Manoranjitham S. K. , Rajendran L. , Parimaladevi R.
Published: September 2023

The severity of the black leaf spot disease of papaya increased with increase in rainfall and during dry spells the disease declined considerably. The maximum disease severity was found during the late winter and spring seasons of the year. In the present study, the disease severity of black spot of papaya was recorded in the TNAU, Orchard at monthly interval for a period of one year from January to December 2018. The results revealed that the disease severity increased progressively from August to November 2018 and the disease was found to be less in summer months. The disease severity was found to reach maximum of 31.21% during the November 2018. The lowest disease severity of 9.45% was found during the month of May 2018.
Estimates of Genetic Parameters for Yield Attributing Characters in Restorer Lines of Rice (Oryza sativa L.)
Authors: Vinay Ippa , Shivani D. , Senguttuvel P. , Barbadikar Kalyani M.
Published: September 2023

The present investigation was conducted  to study the genetic variability, correlation and path coefficient analysis for eight yield and yield attributing traits in 47 (40 improved parental lines + 7 checks) lines of rice. Analysis of variance revealed significant differences among all the treatments under study. High values of PCV and GCV were recorded for traits like number of filled grains per panicle and single plant yield while moderate PCV and GCV recorded for plant height, number of productive tillers per plant, spikelet fertility and 1000 grain weight. High heritability coupled with high genetic advance as percent of mean was observed for the traits namely number of filled grains per panicle, plant height and single plant yield. The traits viz., productive tillers per plant, panicle length, number of filled grains per panicle, spikelet fertility % and 1000-grain weight exhibited significant and positive association with single plant yield. Number of filled grains per panicle, 1000-grain weight, number of productive tillers per plant, plant height and panicle length exhibited positive direct effect on single plant yield indicating that direct selection for these traits would lead to improvement in single plant yield.
Performance of Ridge Gourd Genotype under Prayagraj Agro Climatic Conditions
Authors: Hemasri Nalluri Sai , Prasad V. M. , Bahadur Vijay , Topno Samir E. , Singh Yash Kumar
Published: September 2023

Ridge gourd (Luffa acutangula) is a popular warm-season vegetable that may be grown commercially from seeds. It has a high water and nutrient content, as well as protein, fat, carbs, minerals, and vitamins. Ridge gourd blooms are hermaphrodite, andromonoecious, and gynoecious. The gelatinous chemical Luffein is found in the genus Luffa, which is derived from the word 'loofah', which is utilised in bathing sponges, scrubbing pads, doormats, and pillows. Therefore, the present investigation was carried out at the Horticulture Research Farm, Department of Horticulture, Naini Agricultural Institute, Sam Higginbottom University of Agriculture Technology and Sciences, Prayagraj, Uttar Pradesh during the Kharif season 2022-2023 to check performance of different genotypes of ridge gourd under Prayagraj agro climatic conditions. The experiment was laid in Randomized block design with 9 genotypes and 3 replications. Genotypes were comprised of H1 (AVT-II 2019/RIGHYB-1), H2 (AVT-II 2019/RIGHYB-2), H3 (AVT-II 2019/RIGHYB-3), H4 (AVT-II 2019/RIGHYB-4), H5 (AVT-II 2019/RIGHYB-5), H6 (AVT-II 2019/RIGHYB-6), H7 (AVT-II 2019/RIGHYB-7), H8 (GREEN INDIA-8) and H9 (JAIPURI LONG-9). From the experimental finding it was concluded that the genotype AVT-II 2019/RIGHYB-7 performed best in terms of growth parameters like vine length (269.93 cm), earliness in maturity (59.33 days for first fruit picking) and yield parameters like fruit length (25.23 cm), fruit girth (6.56 cm), and fruit yield per plot (1422.21 g/plot). AVT-II 2019/RIGHYB-7 showed best performance for quality parameters also TSS (4.23°Brix) and Vitamin C content (2.05 mg/100g).
Potential of Zinc Glycinate and Calcium Chloride on Morphological and Yield Characters of Wheat (Triticum aestivum L)
Authors: Kumar Porakala Vineeth , Bara Bineeta M. , Lavanya G. Roopa
Published: September 2023

The present study entitled “Potential of Zinc glycinate and Calcium chloride on morphological and yield characters of Wheat (Triticum aestivum L)” was carried out to assess the effectof seed treatments during 2022-2023 to find the suitable seed treatment for wheat. Thirteen treatments along with control consists of Calcium chloride, Zinc glycinate and Calcium chloride & Zinc Glycinate in different concentrations, individually and combination as well. A Randomized Block Design (RBD) was used for statistical analysis. The main objectives of this experiment was to evaluate the influence of different concentrations of Zinc glycinate and Calcium chloride on morphological and yield parameters of Wheat and to determine the effective treatment for wheat. The results indicated that all treatments recorded significant variation for pre-harvest and post-harvest parameters that were studied. The treatment T12 (Calcium chloride + Zinc glycinate-7%+7%) significantly recorded the higher values in Field emergence(95.55%), Plant height(93.13 cm), Number of tillers per plant(5.73), Spike length(15.18 cm), Seed yield per plant(16.37g) and Harvest Index(40.09%), in comparision with other treatments and lowest recorded in T0(control). This study helps to find the best suitable seed treatment for wheat.
Effect of Different Carbon Sources and Growth Supplements on Growth and Biomass Production of Bioinoculant Azospirillum lipoferum Az204
Authors: Hari Priya S. K.  , Vijila K.
Published: September 2023

In this study the growth and cell yield of Azospirillum lipoferum Az204 was investigated in different carbon sources. Also the effect of adding growth promoting nutrients (0.1% of biotin or 0.1% yeast extract) along with the carbon sources was tested in Nfb medium. The study revealed the ability of A. lipoferum Az204 to grow in malic acid, glucose, succinic acid and glycerol. Although addition of 0.1% of biotin enhanced the cell number and biomass the growth in all carbon sources was at it’s maximum in the presence of 1g L-1 of yeast extract. In glucose and yeast extract combination the strain reached maximum viable cell count of 11.8 log cfu ml-1 and biomass yield of 5.25 g L-1 at the end of 24 hours. It is followed by malic acid + yeast extract which showed cell count of 9.25 log cfu ml-1 and biomass yield of 4.13 g L-1 at 24 h time. Among all the carbon sources glycerol showed minimum growth. Glycerol combined with yeast extract produced viable cell count and biomass yield of 5.5 log cfu ml-1 and 1.82 g L-1 respectively. Succinic acid showed intermediate growth and when used along with yeast extract gave viable cell count and biomass yield of 8.22 log cfu ml-1 and 3.82 g L-1 respectively.
PENDAMPINGAN PENYUSUNAN STRATEGI PEMASARAN SEBAGAI DASAR MENGHADAPI PERSAINGAN UNTUK KEUNGGULAN BERSAING PT BANK KB BUKOPIN CABANG MADIUN
Authors: Handayani Wahyu Prabawati Putri , Susanti Christina Esti
Published: September 2023

PT Bank KB Bukopin merupakan industri perbankan yang menjalankan usaha berupa penghimpunan dana dan penyaluran kredit dengan tujuan untuk menjadi Bank yang tumbuh dan berkembang serta masuk ke kelompok bank menengah di Indonesia dari segi aset. PT Bank KB Bukopin menjalankan usaha berupa penghimpunan dana dan penyaluran kredit yang berfokus pada empat pilar utama yaitu bisnis Mikro, Usaha Kecil dan Menengah (UKM), Bisnis Konsumer serta Bisnis Komersial. Berdasarkan hasil identifikasi menunjukkan bahwa jumlah nasabah PT Bank KB Bukopin terus mengalami penurunan setiap tahunnya sehingga diperlukan strategi pemasaran untuk memenangkan persaingan pasar dan mendapatkan keunggulan bersaing. Analisis menggunakan strategi 7P (product, price, place, promotion, people, process, physical evidence) menyatakan bahwa prioritas utama yang harus diperbaiki oleh PT Bank KB Bukobin Cabang Madiun adalah promotion. Kondisi ini terjadi karena kegiatan promosi yang dilakukan oleh PT Bank KB Bukopin Cabang Madiun tergolong kurang maksimal jika dibandingkan dengan perusahaan pesaing yang sejenis. Tahap identifikasi masalah internal menunjukkan bahwa kegiatan promosi yang sedang dijalankan oleh PT Bank KB Bukopin Cabang Madiun saat ini terbatas pada: (1) sosialisasi ke dinas, sekolah, dan perusahaan; (2) sosial media melalui Instagram; (3) brosur. Oleh karena itu, perlu adanya kegiatan rencana promosi, seperti: 1) Menggunakan influencer marketing, 2) Memasang baliho di pusat keramaian, 3) Mengikuti event marketing, 4) Sms-WA blast, 5) Kerjasama dengan merchant, 6) Sosial media, 7) Kerjasama dengan perusahaan/instansi sebagai salah satu strategi untuk mendapatkan ke­unggulan bersaing.
Digital Phenotype Generation and Time to Encounter Closure
Authors: Mezoff Ethan A. , Gil Lindsay A. , Lee Jennifer A. , Gumer Lindsey , Namjoshi Shweta S. , Hoffman Jeffrey M. , Wendel Danielle
Published: September 2023

This study evaluates whether implementation of a content expert–developed clinical documentation tool can be beneficial to workflow by reducing time from patient arrival to encounter closure among pediatric patients receiving intestinal rehabilitation.
Transition of masonry technology and stone processing in the stone wall of Kagoshima Castle Honmaru
Authors: Hamada Shinichi , Hitsumoto Satoko , Nagatoshi Haruki , Fumoto Kazuyoshi
Published: September 2023

Regarding the stone wall of Kagoshima Castle, the situation after the fire in 1696 (Genroku9) has been clarified to some extent, but there are many unclear points about the situation before 1696. Therefore, in this paper, we will conduct a field survey on the stone wall around the main enclosure, which is the center of Kagoshima Castle, and analyze and consider the processing technology and masonry technology of the stone material. Furthermore, the chronology of the stone wall will be clarified based on drawings and old photographs.
Longitudinal serum neurofilament light kinetics in post‐anoxic encephalopathy
Authors: Disanto Giulio , Villa Michele , Maleska Maceski Aleksandra , Prosperetti Chiara , Gobbi Claudio , Kuhle Jens , Cassina Tiziano , Agazzi Pamela
Published: September 2023

Serum neurofilament light (sNfL) is a promising marker of outcome after cardiac arrest, but its kinetics are unclear. We prospectively measured sNfL concentrations in 62 patients at 0, 1, 3, 5, 7 and 10 days after cardiac arrest. Survivors and non‐survivors had similar sNfL at admission (14.2 [8.6–21.9] vs. 22.5 [14.2–46.9] pg/mL) but largely different at 24 h (16.4 [10.2–293] vs. 464.3 [151.8–1658.2], respectively). The AUC for sNfL concentrations predicting death was above 0.95 from Day 1 to 10 (highest on Day 3). Late sNfL measurements may exert prognostic value, especially when early samples are unavailable or prognosis remains unclear.
Brain olfactory‐related atrophy in isolated rapid eye movement sleep behavior disorder
Authors: Woo Kyung Ah , Kim Heejung , Yoon Eun Jin , Shin Jung Hwan , Nam Hyunwoo , Jeon Beomseok , Kim Yu Kyeong , Lee Jee‐Young
Published: September 2023

Objective

To investigate structural and functional connectivity changes in brain olfactory‐related structures in a longitudinal prospective cohort of isolated REM sleep behavior disorder (iRBD) and their clinical correlations, longitudinal evolution, and predictive values for phenoconversion to overt synucleinopathies, especially Lewy body diseases.

Methods

The cohort included polysomnography‐confirmed iRBD patients and controls. Participants underwent baseline assessments including olfactory tests, neuropsychological evaluations, the Movement Disorders Society–Unified Parkinson's Disease Rating Scale, 3T brain MRI, and 18F‐FP‐CIT PET scans. Voxel‐based morphometry (VBM) was performed to identify regions of atrophy in iRBD, and volumes of relevant olfactory‐related regions of interest (ROI) were estimated. Subgroups of patients underwent repeated volumetric MRI and resting‐state functional MRI (fMRI) scans after four years.

Results

A total of 51 iRBD patients were included, with 20 of them converting to synucleinopathy (mean time to conversion 3.08 years). Baseline VBM analysis revealed atrophy in the right olfactory cortex and gyrus rectus in iRBD. Subsequent ROI comparisons with controls showed atrophy in the amygdala. These olfactory‐related atrophies tended to be associated with worse depression, anxiety, and urinary problems in iRBD. Amygdala 18F‐FP‐CIT uptake tended to be reduced in iRBD patients with hyposmia (nonsignificant after multiple comparison correction) and correlated with urinary problems. Resting‐state fMRI of 23 patients and 32 controls revealed multiple clusters with aberrant olfactory‐related functional connectivity. Hypoconnectivity between the putamen and olfactory cortex was associated with mild parkinsonian signs in iRBD. Longitudinal analysis of volumetric volumetric MRI in 22 iRBD patients demonstrated four‐year progression of olfactory‐related atrophy. Cox regression analysis revealed that this atrophy significantly predicted phenoconversion.

Interpretation

Progressive atrophy of central olfactory structures may be a potential indicator of Lewy body disease progression in iRBD.
Strict blood pressure control following thrombectomy is associated with neuronal injury and poor functional outcome
Authors: Hahn Marianne , Hayani Eyad , Bitar Lynn , Gröschel Sonja , Steffen Falk , Protopapa Maria , Othman Ahmed , Bittner Stefan , Zipp Frauke , Gröschel Klaus , Uphaus Timo
Published: September 2023

Objective

Mechanical thrombectomy (MT) has become standard treatment in acute ischemic stroke due to large vessel occlusion (LVO). However, optimal blood pressure (BP) management following successful recanalization remains unclear. We aim to investigate the association of strictly achieving BP targets of ≤160/90 mmHg with the extent of neuronal loss and functional outcome.

Methods

In patients prospectively enrolled in the Gutenberg‐Stroke‐Study (May 2018–November 2019), BP was measured half‐hourly for 24 h following MT. Based on achieving BP target of ≤160/90 mmHg, patients with successful recanalization of LVO were divided into “low‐BP” group (BP ≤ 160/90 mmHg) or “high‐BP” group (BP > 160/90 mmHg). Neuronal loss was quantified by serum‐based measurement of neurofilament light chain (sNfL) after three days. BP groups and association of BP parameters with sNfL were investigated by correlation analyses and multiple regression modeling.

Results

Of 253 enrolled patients (mean age 73.1 ± 12.9 years, 53.4% female), 165 met inclusion criteria. 21.2% (n = 35) strictly achieved “low‐BP” target. “low‐BP” was associated with unfavorable functional outcome at 90‐day follow‐up (aOR [95%CI]: 5.88 [1.88–18.32], p = 0.002) and decreased health‐related quality of life (mean EQ‐5D‐index 0.45 ± 0.28 vs 0.63 ± 0.31, p = 0.009). sNfL levels were increased in “low‐BP” patients (median [IQR] 239.7 [168.4–303.4] vs 118.8 [52.5–220.5] pg/mL, p = 0.026). Hypotensive episodes were more frequent in the “low‐BP” group (48.6% vs 29.2%, p = 0.031). sNfL level could identify patients who had experienced hypotensive episodes with high discriminative ability (AUC [95%CI]: 0.68 [0.56–0.78], p = 0.007).

Interpretation

Strict BP control (≤160/90 mmHg) within 24 h following successful recanalization of LVO by MT is associated with increased neuronal injury, displayed by higher sNfL levels, and poorer functional outcome, potentially indicating hypotension‐induced neuronal loss during post‐MT phase.
Security‐based fault detection filtering design for fuzzy singular semi‐Markovian jump systems via improved dynamic event‐triggering and quantization protocols
Authors: Kong Linghuan , Luo Mengzhuo , Cheng Jun , Katib Iyad , Shi Kaibo , Zhong Shouming
Published: September 2023

This article concerns the problem of event‐protocol‐based asynchronous fault detection filtering design for discrete‐time fuzzy singular semi‐Markovian jump systems subjected to system parameters uncertainties, unmatched one‐sided Lipschitz nonlinearities and multi‐cyber‐attacks. First, a well‐designed model structure is proposed to integrate two dynamic quantizers and an improved dynamic event‐triggered protocol into a unified framework to reduce the amount of data in the network transmission and rationalize the use of limited network communication bandwidth resources. Especially, the event‐triggering threshold parameter can be continuously adjusted over the time based on the fluctuation of the network signal. Second, a novel triple‐cyber‐attacks platform is established, of which including random deception attacks, random replay attacks and aperiodic DoS attacks. And with help of the extended decoupling strategy and iterative techniques, the co‐design conditions of the stochastic admissibility with a level of performance are derived for the fault filtering error systems. Finally, two examples are provided to demonstrate the effectiveness and feasibility of the proposed algorithm.
Highly Reversible Zinc‐Air Batteries at −40 °C Enabled by Anion‐Mediated Biomimetic Fat
Authors: Deng Danni , Wu Jiao , Feng Qingguo , Zhao Xin , Liu Mengjie , Bai Yu , Wang Jinxian , Zheng Xinran , Jiang Jiabi , Zhuang Zechao , Xiong Xiang , Wang Dingsheng , Lei Yongpeng
Published: September 2023

The wide application of portable electrical equipment, aerial vehicles, smart robotics, etc. has boosted the development of advanced batteries with safety, high energy density, and environmental adaptability. Inspired by the fat layer on animal bodies, biomimetic fat is constructed as electrolytes of solid‐state zinc‐air batteries to achieve excellent cycling performance at low temperatures. Via tailored anion‐H2O interaction, the antifreezing gel electrolytes, with the multi‐performance of interface compatibility, temperature adaptability, and stable power supply simultaneously, build robust Zn|electrolyte interface, thus promoting uniform interfacial electric fields and Zn deposition. Excellent long‐term cyclability of 120 h at a high current density of 50 mA cm−2 are exhibited at 25 °C. Moreover, at −40 °C, a record‐long cycling life of 205 h at a current density as large as 10 mA cm−2 is achieved.
Engineering and Controlling Perovskite Emissions via Optical Quasi‐Bound‐States‐in‐the‐Continuum
Authors: Csányi Evelin , Liu Yan , Rezaei Soroosh Daqiqeh , Lee Henry Yit Loong , Tjiptoharsono Febiana , Mahfoud Zackaria , Gorelik Sergey , Zhao Xiaofei , Lim Li Jun , Zhu Di , Wu Jing , Goh Kuan Eng Johnson , Gao Weibo , Tan Zhi‐Kuang , Leggett Graham , Qiu Cheng‐Wei , Dong Zhaogang
Published: September 2023

Metal halide perovskite quantum dots (PQDs) have emerged as promising materials due to their exceptional photoluminescence (PL) properties. A wide range of applications could benefit from adjustable luminescence properties, while preserving the physical and chemical properties of the PQDs. Therefore, post‐synthesis engineering has gained attention recently, involving the use of ion‐exchange or external stimuli, such as extreme pressure, magnetic and electric fields. Nevertheless, these methods typically suffer from spectrum broadening, intensity quenching or yield multiple bands. Alternatively, photonic antennas can modify the radiative decay channel of perovskites via the Purcell effect, with the largest wavelength shift being 8 nm to date, at an expense of fivefold intensity loss. Here, this work presents an optical nanoantenna array with polarization‐controlled quasi‐bound‐states‐in‐the‐continuum resonances, which can engineer and shift the photoluminescence wavelength over a ≈39 nm range and confers a 21‐fold emission enhancement of FAPbI3 perovskite QDs. The spectrum is engineered in a non‐invasive manner via lithographically defined antennas and the pump laser polarization at ambient conditions. This research provides a path toward advanced optoelectronic devices, such as spectrally tailored quantum emitters and lasers.
Direct Mapping of Cytomechanical Homeostasis Destruction in Osteoarthritis Based on Silicon Nanopillar Array
Authors: Yu Dengjie , Nie Qingbin , Xue Jiangtao , Luo Ruizeng , Xie Shiwang , Chao Shengyu , Wang Engui , Xu Linlin , Shan Yizhu , Liu Zhuo , Li Yusheng , Li Zhou
Published: September 2023

Osteoarthritis (OA) is the most prevalent joint degenerative disease characterized by chronic joint inflammation. The pathogenesis of OA has not been fully elucidated yet. Cartilage erosion is the most significant pathological feature in OA, which is considered the result of cytomechanical homeostasis destruction. The cytomechanical homeostasis is maintained by the dynamic interaction between cells and the extracellular matrix, which can be reflected by cell traction force (CTF). It is critical to assess the CTF to provide a deeper understanding of the cytomechanical homeostasis destruction and progression in OA. In this study, a silicon nanopillar array (Si‐NP) with high spatial resolution and aspect ratio is fabricated to investigate the CTF in response to OA. It is discovered that the CTF is degraded in OA, which is attributed to the F‐actin reorganization induced by the activation of RhoA/ROCK signaling pathway. Si‐NP also shows promising potential as a mechanopharmacological assessment platform for OA drug screening and evaluation.
In Situ Regulating Cobalt/Iron Oxide‐Oxyhydroxide Exchange by Dynamic Iron Incorporation for Robust Oxygen Evolution at Large Current Density
Authors: Li Dongyang , Xiang Rong , Yu Fang , Zeng Jinsong , Zhang Yong , Zhou Weichang , Liao Liling , Zhang Yan , Tang Dongsheng , Zhou Haiqing
Published: September 2023

The key dilemma for green hydrogen production via electrocatalytic water splitting is the high overpotential required for anodic oxygen evolution reaction (OER). Co/Fe‐based materials show superior catalytic OER activity to noble metal‐based catalysts, but still lag far behind the state‐of‐the‐art Ni/Fe‐based catalysts probably due to undesirable side segregation of FeOOH with poor conductivity and unsatisfied structural durability under large current density. Here, a robust and durable OER catalyst affording current densities of 500 and 1000 mA cm−2 at extremely low overpotentials of 290 and 304 mV in base is reported. This catalyst evolves from amorphous bimetallic FeOOH/Co(OH)2 heterostructure microsheet arrays fabricated by a facile mechanical stirring strategy. Especially, in situ X‐ray photoelectron spectroscopy (XPS) and Raman analysis decipher the rapid reconstruction of FeOOH/Co(OH)2 into dynamically stable Co1‐xFexOOH active phase through in situ iron incorporation into CoOOH, which perform as the real active sites accelerating the rate‐determining step supported by density functional theory calculations. By coupling with MoNi4/MoO2 cathode, the self‐assembled alkaline electrolyzer can deliver 500 mA cm−2 at a low cell voltage of 1.613 V, better than commercial IrO2(+)||Pt/C(‐) and most of reported transition metal‐based electrolyzers. This work provides a feasible strategy for the exploration and design of industrial water‐splitting catalysts for large‐scale green hydrogen production.
Regulating Intramolecular Electron Transfer of Nickel‐Based Coordinations through Ligand Engineering for Aqueous Batteries
Authors: Su Yichun , Hu Jinliang , Yuan Guoqiang , Zhang Guangxun , Wei Wenxian , Sun Yangyang , Zhang Xiaoxing , Liu Zheng , Suen Nian‐Tzu , Chen Hsiao‐Chien , Pang Huan
Published: September 2023

The integration of electronic effects into complexes for the construction of novel materials has not yet attracted significant attention in the field of energy storage. In the current study, eight one‐dimensional (1D) nickel‐based salicylic acid  complexes (Ni‐XSAs, X = pH, pMe, pMeO, mMe, pBr, pCl, pF, and pCF3), are prepared by ligand engineering. The coordination environments in the Ni–XSAs are explored using X‐ray absorption fine structure spectroscopy. The charge transfer of the complexes is modulated according to the difference in the electron‐donating ability of the substituents, in combination with frontier orbital theory. Furthermore, density functional theory is used to investigate the effect of the substituent position on the electronic properties of the complexes. Ni‐mMeSA exhibits better electrical conductivity than Ni‐pMeSA. The electrochemical performance of Ni‐mMeSA as an aqueous battery cathode is remarkably improved with a maximum energy density of 0.30 mWh cm−2 (125 Wh kg−1) and a peak power density of 33.72 mW cm−2 (14.03 kW kg−1). This study provides ideas for the application of new coordination chemistry in the field of energy materials science.
Electrochemical and Biocatalytic Signal‐Controlled Payload Release from a Metal–Organic Framework
Authors: Sterin Ilya , Hadynski John , Tverdokhlebova Anna , Masi Madeline , Katz Evgeny , Wriedt Mario , Smutok Oleh
Published: September 2023

A metal–organic framework (MOF), ZIF‐8, which is stable at neutral and slightly basic pH values in aqueous solutions and destabilized/dissolved under acidic conditions, is loaded with a pH‐insensitive fluorescent dye, rhodamine‐B isothiocyanate, as a model payload species. Then, the MOF species are immobilized at an electrode surface. The local (interfacial) pH value is rapidly decreased by means of an electrochemically stimulated ascorbate oxidation at +0.4 V (Ag/AgCl/KCl). Oxygen reduction upon switching the applied potential to −0.8 V allows to return the local pH to the neutral/basic pH, then stopping rapidly the release process. The developed method allows electrochemical control over stimulated or inhibited payload release processes from the MOF. The pH variation proceeds in a thin film of the solution near the electrode surface. The switchable release process is realized in a buffer solution and undiluted human serum. As the second option, the pH decrease stimulating the release process is achieved upon an enzymatic reaction using esterase and ester substrate. This approach potentially allows the release activation controlled by numerous enzymes assembled in complex biocatalytic cascades. It is expected that related electrochemical or biocatalytic systems can represent novel signal‐responding materials with switchable features for delivering (bio)molecules within biomedical applications.
Probing Enhanced Electrochemical Performance of Poly (3,4‐ethylenedioxy Thiophene) Encapsulated 5.3 V Spinel LiCoMnO4 Cathode for Li‐ion Batteries
Authors: Sreedeep Sreekumar , Lee Yun‐Sung , Aravindan Vanchiappan
Published: September 2023

Herein, the effect of poly(3,4‐ethylenedioxythiophene) polystyrene sulfonate (PEDOT) coating is reported on the electrochemical properties of high voltage, 5.3 V lithium cobalt manganese oxide (LiCoMnO4, LCMO) cathodes. Scalable precipitation followed by a wet coating method is employed for the synthesis of LCMO@PEDOT. Various analytical studies are performed to validate the performance of the cathode. The cycling profile exhibits an enhanced electrochemical performance among the LCMO@PEDOT compared to that of pristine LCMO in a half‐cell configuration. Also, the LCMO@PEDOT: 0.5–3 wt.% is optimized to show better electrochemical performance. The diffusion coefficient calculated from both cyclic voltammetry and electrochemical impedance spectroscopy (EIS) exhibits an increase in the magnitude from PEDOT coating of 0.5 to 3 wt.% in the order of ≈10−12 cm2 s−1. An in‐operando X‐ray diffraction and in‐situ EIS are performed to validate the electrochemical activity. The full‐cell assembly is also fabricated with spinel Li4Ti5O12 (LTO) anode under balanced loading conditions. The LCMO@PEDOT (1–3 wt.%)/LTO exhibits better electrochemical performance compared to pristine LCMO/LTO. In addition, a temperature study of full‐cell is carried out within the range of −10 to 20 °C and compared.