bluuebunny/crossref_metadata_2025 huggingface dataset:
Internalisasi Nilai-Nilai Nasionalisme dalam Pembelajaran Pendidikan Aswaja dan ke-NU-an di Madrasah Aliyah Nasy’atul Muta’allimin
Authors: Amrullah Amrullah , Hadi Abd
Published: June 2023

The background of this research is the attitude of a student who received Aswaja dan NU-ness education who has a nationalist attitude. The purpose of this research is to analyze the extent to which the Aswaja dan NU-ness Education lessons in which there is knowledge about nationalism can become nationalist students. This study used a qualitative approach with descriptive types and data collection techniques used, observation, interviews, and documentation. The results of this study stated that in the lesson there was material about mabadi khaira ummah, ukhuwah wathaniyah, and Nahdlatul Ulama in the nation s struggle. The nationalist attitude of students obeys teachers, school rules, sings subbanul wathan songs, attends ceremonies every Monday and santri day.
Experiential Viewing: Reimagining the Online Display of World War II Aerial Reconnaissance Photography with IIIF
Authors: Wilson Hilary
Published: June 2023

This thesis aims to identify how cultural heritage institutions can use emerging new digital technologies such as the International Image Interoperability Framework (IIIF) to improve interpretation and discovery of aerial reconnaissance photography collections online. The practical aspect of this project involves the creation of a IIIF manifest for a World War II (WWII) photographic sortie from the National Collection of Aerial Photography (NCAP), in Edinburgh, Scotland. For contextual background on the collection at NCAP, a brief history of aerial photography from 1889 until the end of WWII is presented. In order to understand the current state of online exhibition of these collections, a survey of NCAP’s current online display of their collection, along with the Aeriofototeca Nazionale (Rome, Italy) and the Laurier Military History Archive (Wilfrid Laurier University, Waterloo, Ontario, Canada) was conducted.
Experimental and Numerical Investigation of Thermal Storage Medium for Ground Source Heat Pump Applications
Authors: Nguyen Hiep
Published: June 2023

The thesis begins with a literature review of the current status of ground source heat pump (GSHP) systems. The limitations of these systems are discussed and the potential to couple phase change material (PCM) with a GSHP system is explored and presented. The research focuses on a paraffin- based PCM for the experimental studies in this thesis due to its low-cost/non-toxic properties.

The development of a bentonite-sand tank experiment is presented in Chapter 2. A steel casing, which emulates a single borehole positioned at the centre of a 1 m diameter tank was used to study the energy transfer rate from the borehole to the surrounding material in the tank. Using the obtained experimental results, the numerical model for this experiment was developed and validated in Chapter 4. A series of studies were performed in order to determine the temperature distribution profile of the tank for different bentonite thermal conductivity values. Due to a lack of drilling space, a bentonite-based thermal storage medium (TSM) is not a viable solution for many building owners and developers in urban settings. As such, the findings from this study were used towards the design of the concrete tank for testing in Chapter 3 in regards to the placement of the boreholes and PCM tubes.

The development of a concrete tank experiment is presented in Chapter 3. Four boreholes and eight PCM tubes were installed in order to characterize the heat transfer performance and the potential for energy storage with PCM for concrete-based applications. Due to the high thermal conductivity value of concrete, the temperature distribution at various depths and angular positions of the tank were relatively uniform.

In Chapter 5 a numerical model of the concrete tank experiment was developed and validated. The performance of a concrete-based heat exchanger tank with and without PCM were investigated. The findings from these results were essential to inform the design and installation of a full-scale system that is now being used for heating and cooling a residential dwelling.
“Mohammed: Perspectieven op de Profeet” Kitabı Üzerine Bir Değerlendirme
Authors: Kayalık Murat
Published: June 2023

Hz. Muḥammed hakkındaki yazılan kitapların çoğu, Hz. Muḥammed'in hayatının yüzeysel tarihsel gerçekleriyle sınırladığı gözlemlenmektedir. Böyle yapmak suretiyle, Hz. Muḥammed’in ölümünden bu yana geçen yaklaşık on dört yüzyıl göz ardı edilmektedir. Gerçek şu ki, Hz. Muḥammed algısı (algılanma tarihi) hem İslām dünyasında hem de Batı’da birçok yönden değişmiş ve yeniden şekillenmiştir. Bu çalışmada, akademisyen Christian Lange’nın (doğ. 1975) Hollandaca olarak kaleme aldığı Muhammed: Peygamber Üzerine Algılar adlı kitabın tanıtımı yapılmıştır. Eser, Lange’nın 2014'ten beri Hollanda’nın Utrecht şehrinde bulunan Utrecht Üniversitesi'nde verdiği bir dizi derse dayanmakta ve Hz. Muḥammed sonrası, peygamber algı(lanma) tarihine kuşbakışı bir resim sunmaktadır. Üç farklı Hz. Muḥammed portresi çizen yedi bölüm, kısa bir giriş ve bir sonuçtan oluşan kitap, temelde tarihî şahsiyet olarak Muḥammed, dindar olarak Muḥammed ve Batı(lı) gözünde Muḥammed konuları ele almaktadır. Bu araştırma, diğer siyer kitaplarından ayıran en önemli özellik, Hz. Peygamberin salt biyografisine değil, Hz. Muḥammed sonrası insanlığın belleğindeki peygamber tasavvurlarına ve tarihsel sürece odaklanmasıdır.
Морфологическое исследование регенерации костной ткани лабораторных животных при имплантации гранул диоксида циркония с биомодульным распределением пор
Authors: Рогожников А.Г. , Шулятникова О.А. , Рогожников Г.И. , Четвертных Л.А.
Published: June 2023

Цель исследования. Морфологическая оценка регенераторных способностей костной ткани экспериментальных животных (кроликов) при имплантации образцов стабилизированной диоксидом церия керамики из диоксида циркония в виде гранул с бимодальным распределением пор.
Объекты и методы исследования. Для экспериментальной части работы была разработана технология получения гранул модифицированного диоксида циркония размером 0,7-1,0 мм с пористостью до 80 %, с бимодальным распределением микропор величиной 2,0-4,5 мкм и нанопор до 10,0 нм. В качестве объектов для морфологического метода исследования служили фрагменты костной ткани нижней челюсти экспериментальных животных из зоны имплантации модифицированных гранул диоксида циркония.
Результаты исследования и их обсуждение. Результаты исследования и их обсуждение. Результаты исследования показали, что высокая пористость гранул керамики из1диоксида циркония с бимодальным распределением микро- и нанопор способствует более плотному соприкосновению их со структурами костной ткани. Гранулы диоксида циркония являются инертным материалом, содержащим кристаллы гидроксиапатита и способствуют эффективному процессу репаративного гистогенеза костной ткани и ее васкуляризации с обеспечением плотного соединения без признаков развития патологических изменений тканей в зоне расположения имплантируемого керамического материала.
Заключение. Применение гранул диоксида циркония в практической стоматологии перспективно для ускорения и повышения качества костной регенерации при синус-лифтинге с непосредственной установкой зубного имплантата; для устранения дефектов, прилегающих к имплантату костной ткани путем пломбирования костных дефектов; для наращивания или реконструкции костной ткани челюстно-лицевой области с сохранением высокой степени эстетичности.
Уровень содержания интерлейкинов в ротовой жидкости при травматических переломах нижней челюсти
Authors: Походенько-Чудакова И.О. , Абдуламир Али Али Тергам , Картун Л.В. , Ходосовская Е.В.
Published: June 2023

Цель исследования. Анализ иммунологических показателей (уровней содержания интерлейкинов в ротовой жидкости) у пациентов с травматическими переломами нижней челюсти. Объекты и методы исследования. Группа 1 включала 61 человека в возрасте 18-58 лет с диагнозом «травматический перелом нижней челюсти». Данные здоровых соматически и стоматологически лиц взяты из специальной литературы и учтены как группа 2 (контрольная). Определение уровней содержания интерлейкина-1β (IL-1β), интерлейкина-6 (IL-6), интерлейкина-8 (IL-8) в ротовой жидкости выполняли при помощи иммуноферментного анализа, результат выражали в пг/мл. Полученные данные подвергали статистической обработке при помощи пакета прикладных программ Statistica 10.0. Результаты исследования и их обсуждение. Уровень содержания IL-1β в ротовой жидкости группы 1 составил 14,15 (9,85-23,30), уровень IL-6 был 16,95 (7,05-85,00), уровень содержания IL-8 равнялся 1705,0 (690,0-1965,0). При сравнении показателей групп 1 и 2 по критерию Краскела-Уоллиса для множественных сравнений были выявлены достоверные различия уровня содержания в ротовой жидкости IL-6z = 4,16 (H = 20,23, p = 0,00) и уровня содержания IL-8z = 3,32 (H = 11,82, p = 0,03). Заключение. Профиль уровня содержания интерлейкинов в ротовой жидкости информативно отражает как наличие травматического повреждения нижней челюсти, так и изменение гомеостаза полости рта при указанном заболевании, а также характеризует влияние последнего на организм в целом. Это дает основание для использования указанных показателей при оценке влияния отдельных негативных факторов полости рта на клиническое течение травматического повреждения челюсти.
FEATURES OF INDUSTRIAL ENTERPRISE STAFF MOTIVATION IN CRISIS CONDITIONS
Authors: Ivanova N. S. , Rykun S. S.
Published: June 2023

Objective. The objective of this article is to study the peculiarities of the motivation of the personnel of an industrial enterprise in crisis conditions.

Methods. To achieve the objective, the synthesis method, the theopetic-analytical method, the analysis method, horizontal analysis, vertical analysis, the method of statistical analysis, the generalization method, the methods of induction and deduction, and the method of graphic analysis were used.

Results. A theoretical study of the system of motivation of the organization's personnel in crisis conditions was conducted; the importance of the motivational aspect of anti-crisis personnel management is proven; analyzed the existing system of material support of the top management of ArcelorMittal for the period 2019-2021; As a result of the conducted research, it was recognized that there is a well-founded motivation system at ArcelorMittal, with established principles, philosophy, organizational and regulatory support. With this system, material incentives are implemented by management by goals with gradation by positions and by elements of material incentives. A feature of the motivation system's adaptability to crisis conditions is the reduction of the rates of elements of remuneration of top management and, in addition, crisis phenomena can negatively affect the level of achievement of defined goals and thereby reduce the amount of remuneration. The system of intangible support is also characterized by diversity and systematicity, in which all employees are involved and which is aimed at: communication (support in difficult hours), identifying the needs of employees and their professional growth. The principles and philosophy of the ArcelorMittal motivation system were also reflected in the ArcelorMittal Kryvyi Rih personnel management system.
Kotoutumiskoulutuksen opetussuunnitelman perusteet kuvaa tavoitettaan osallisuutta epämääräisesti ja kapeasti
Authors: Kekki Miika , Ronkainen Reetta , Seppälä Tanja , Weide Marjukka
Published: June 2023

Kotoutumiskoulutuksen uudessa perusteasiakirjassa korostuu osallisuuden käsite. Se jää kuitenkin määrittelemättä: osallisuuteen viitataan sekä kapearajaisesti työmarkkinaosallisuutena että epäsuorasti niin, että käsitteen varsinainen merkitys jää avoimeksi. Tutkimuskirjallisuudessa osallisuus edellyttää laaja-alaista sosiaalis-yhteiskunnallista kuulumista ja yhdenvertaisuutta.
Jännitteinen teos pragmatistista
Authors: Hämäri Severi
Published: June 2023

Kirja on nimensä mukaisesti yleisesitys Deweyn esteettisestä teoriasta. Samalla se on esteettis-filosofinen tutkielma, joka puolustaa Deweyn teorian omaperäisyyttä ja paikkaa nykytutkimuksen pohjana. Kaksinaisen tavoitteensa vuoksi kirjassa on pienimuotoinen sisäinen jännite: onko se yleisteos, joka on suunnattu kaikille Deweyn ajattelusta kiinnostuneille vai erityisesti juuri estetiikan tutkijoille suunnattu puheenvuoro?
PELATIHAN BUDIDAYA IKAN HIAS DAN CARA PEMASARANNYA DI MEDIA SOSIAL UNTUK MENAMBAH PENDAPATAN
Authors: Taram Hafiz Santak , Rahmawati Rafika , Mardiah Siti
Published: June 2023

The Covid-19 era had a big impact, especially for the lower middle class, because the economy was declining and there were also many reductions in the number of employees in various companies. So that there is a need for innovation to open your own business, one of the easy and inexpensive businesses is ornamental fish cultivation. The research method used in the study was training for ornamental fish cultivation with the result of increasing the knowledge and understanding of residents about the cultivation and marketing of betta type ornamental fish as a business opportunity to increase income during the Covid-19 pandemic.
WEBINAR MENGENAI KONSEP ILMU FALAK DAN MEMPRAKTEKKAN TATA CARA MENGHITUNG ARAH KIBLAT
Authors: Alamsyah Muhammad Fauzi , Hambali Yoyo , Ash Shabah Musyafa Amin
Published: June 2023

Prayer times are basically determining the daily position of the sun. The movement of the sun which is the standard of prayer times is the concern of Muslims throughout the ages. Astronomy as part of astronomy is useful for general knowledge and worship. The benefits of Falak science in worship are determining the Qibla direction, prayer times, the beginning of the month and eclipses. Therefore, this community service activity is important to do in order to increase confidence in worship and straighten people's understanding. The implementation method is in the form of Webinar counseling using the Zoom meeting platform. The results of this activity are increasing insight into the concept of astronomy and being able to practice the concept of astronomy in daily activities.
MENINGKATKAN KEMANDIRIAN PANGAN SELAMA PANDEMI COVID-19 DENGAN BUDIKDAMBER (BUDIDAYA IKAN DALAM EMBER) DI DESA MEKARWANGI
Authors: Ramadhan Fajra Wahyu , Suprihatin Suprihatin , As-shabah Musyaffa Amin
Published: June 2023

Cultivation is one of the important sectors in human development and related to the environment in society. Cultivation that is easily carried out by the community with easy facilities and maintenance that does not require large capital is fish farming in buckets or often called BUDIKDAMBER. The method used in this research is to educate the public about fish farming in buckets. The result of cultivating fish in buckets is that people can cultivate in buckets which require small capital so it's easy to do.
SEMINAR ONLINE PERENCANAAN KEUANGAN SYARIAH
Authors: Suherni Siti , Isfandayani Isfandayani , Isnandar Fajri Ryan
Published: June 2023

Indonesia confirmed its first case of infection with the corona virus that causes Covid-19 in early March 2020. The decline in economic growth due to the Covid-19 pandemic can trigger impacts on other aspects such as social aspects. The role of the government and educators is needed to carry out outreach in the economic field such as financial planning during this covid outbreak. The method used in this community service is outreach to the public regarding the importance of sharia financial planning. The results in this study are to add knowledge to the community regarding Islamic financial planning.
MEMBANGUN KERJASAMA ANTAR KELUARGA MELALUI POLA ASUH KARAKTER ISLAMI DI LINGKUNGAN MASYARAKAT
Authors: Nurhaliza Siti , Ghofur Abdul , Lubis Rabiyanur
Published: June 2023

As parents, we must have a way of parenting and methods in the education process of the child. There are several methods in educating children, namely: democratic parenting, permissiveness and authority. And in providing care for children, several strategies are needed to provide education with exemplary methods, habituation, attention, advice and punishment methods. Of course, carrying out parenting and methods in the child's education process has an outline goal, namely to make the process of habituation to good things so that it affects the child's personality in adulthood. The main program is about the impact and how to address the problem of cyberbullying. Maybe this is often taken for granted, even though this can all be very fatal for the victim of cyberbullying. Cyberbullying can happen to anyone, so we all have to take this seriously, so that a safe environment will be formed.
Bulgarian Encyclopedia Scientific Information Centre
Authors: Todorova Milena , Lazova Victoria
Published: June 2023

The Bulgarian Encyclopedia Scientific Information Centre is a constituent part of the Bulgarian Academy of Sciences, responsible for the compilation and publication of encyclopedias and encyclopedic reference books. Its work follows the tradition of encyclopedic knowledge in Bulgarian culture dating back to medieval collections from the court of Tsar Simeon I in the 9th to 10th centuries. Encyclopedic content is also contained in the first Bulgarian schoolbook, published in 1824, and in the growing interest in reference publications before and after the liberation of Bulgaria from the Ottoman Empire in 1878. The first Bulgarian general encyclopedia, the Encyclopedic Dictionary, was published in 1899–1907, followed by the popular Bulgarian Encyclopedia A-Ya in 1936. A specialised unit for the preparation of encyclopedias and encyclopedic reference literature was established at the Bulgarian Academy of Sciences in 1955 under the name Bulgarian Encyclopedia, and was renamed the Bulgarian Encyclopaedia Scientific Information Centre in 2003. The Centre’s mission is to disseminate scientific knowledge widely and in an accessible form. The Centre’s main activities include the compilation and preparation of general one-volume and multi-volume encyclopedias, the development of methodological guidelines and technologies for new publications, the preparation of thematic vocabularies of the articles and illustrations of the editions, and editorial and compiling work. The publications of the Bulgarian Encyclopedia Scientific Information Centre are of a high academic level, and the editorial and compilation work is carried out by experienced scientific encyclopedic editors, which guarantees the high professional standards of the publications. Multiple editions of the Bulgarian Encyclopedia have been published, covering a wide range of topics such as history, science, culture, and more. The Centre has also published thematic encyclopedias and electronic versions of its work, and collaborates with various organisations and publishers to continue its responsible activity of national importance
Generic and Relations in Monomial Groups Over an Associative Ring (Part I)
Authors: Satarov Zh. , Mamaziaeva E. , Mambetov Zh. , Suiunbek kyzy A.
Published: June 2023

The question of representing linear groups (and related constructions) by generating elements and defining relations has always been of great interest in general combinatorial group theory. Today, there are a large number of journal and book materials in this direction. Research methods have also emerged. One such method is the (universal) combinatorial method for transforming letters. The essence of this method is to convert the words of the selected alphabet of the group, Monn(R), n≥2, under consideration to their standard forms c 1≠0. The paper gives a description in terms of generators and defining relations of the monomial group defined over an arbitrary associative ring with. Using this result, we find a combinatorial description of also the projective factor PMonn(R)of the named group. When solving these issues, the mentioned method of transformation was used.
Societal Security: A New Conceptual Framework to Analyse Ultra-Orthodox (Haredi) Politics in Israel
Authors: BELDER Ferit
Published: June 2023

Haredi (ultra-orthodox) political parties in Israel, namely Yahadut HaTora and Shas, have been constantly affecting the domestic political agenda. Despite already flourished literature that covers the various roles these parties play; security dimension is yet to be addressed so far. This paper aims to analyse the Haredi politics in Israel in the identity-security nexus by questioning the political reflections of the Haredi parties’ persistent attachments to the security language in four core topics which are the Haredi educational autonomy, the exemption of religious school (yeshiva) students from the army service, the conversion to Judaism process (giyur), and the nationwide Shabbat regulations. By analysing the coalition documents that Haredi parties took part in, campaign posters of the 2013 and the 2015 elections, individual and institutional Haredi responses to certain crises regarding these topics, this paper claims that Haredi politics is organized by the articulation of
identity-security concerns at varied levels.
Learning to live with discrimination
Authors: Oshodi Darasimi
Published: June 2023

Otherness is one issue that comes up when discussing migration, and when it comes to asylum seeking in Europe, the topic of discrimination is a pivotal one also due to the rise of nationalistic political parties in the last few years. This paper therefore uses narrative interviews and Axel Honneth’s theory of recognition to explore the experiences of two asylum seekers with discrimination in Italy, and how they were responding to these experiences. The aim of the paper is to highlight how discrimination impacted differently on the participants’ construction of self-identity and their different strategies when it comes to becoming part of the host society.
Influence of planting pattern on peanut ecosystem daytime net carbon uptake, evapotranspiration, and water-use efficiency using the eddy-covariance method
Authors: Zhang Gengsheng , Leclerc Monique Y. , Singh Navjot , Tubbs Ronald Scott , Montfort Walter Scott
Published: June 2023

Peanut is planted in a pattern of either single or twin rows in Georgia, USA. However, limited attention has been paid to the impact of planting pattern on the carbon footprint and how the net carbon uptake is intertwined with the amount of water used to determine the ecosystem water-use efficiency (WUE) in peanut. This paper reports on the relationship between the amount of carbon produced to the amount of water used in peanut, carbon dioxide flux, and crop evapotranspiration of peanut in a single- or in a twin-row planting pattern measured using the eddy-covariance method. To the best of our knowledge, the present study is unique in that it examines for the first time the effect of planting pattern on the net carbon uptake and WUE. The two-year study took place in contrasting weather conditions with the 2016 year experiencing a higher vapor pressure deficit and lower precipitation than in the 2018 year. In this study, field-scale daytime net carbon ecosystem exchange (CO2 fluxes), ET and WUE of single- and twin-row peanut were compared using the eddy-covariance technique. Results showed that in 2018, both the net carbon uptake from the atmosphere and the WUE of twin-row peanut were significantly greater than those in the single-row peanut by 7-10% and ~9% respectively, for pod filling and seed maturity growth stages (aGDD 1000-2000 and aGDD > 2000). In 2016, the net daytime carbon uptake and WUE of peanut were similar for both planting patterns during pod filling (aGDD 1000-2000). Higher precipitation and lower VPD in 2018 likely resulted in greater peanut yield in twin-row as compared to single-row with abundant precipitation. Owing to the fast canopy growth rate in twin-row peanut, results suggest that during the vegetative stage (aGDD<500) in 2016, both daytime net carbon uptake from the atmosphere and WUE were considerably greater in twin-row than single-row by 32% and 27%, respectively. Given that in both years, the ET from both planting patterns was similar, it appears that the determination of WUE in both planting patterns was more impacted by changes in daytime net carbon uptake than evapotranspiration. The results of this study suggest the possibility that the higher WUE at the critical stages of twin-row peanut in 2018 are likely to lead to greater yield than single-row peanut. This should be confirmed with further year-to-year investigations.
A benchmark study of convolutional neural networks in fully automatic segmentation of aortic root
Authors: Yang Tingting , Zhu Guangyu , Cai Li , Yeo Joon Hock , Mao Yu , Yang Jian
Published: June 2023

Recent clinical studies have suggested that introducing 3D patient-specific aortic root models into the pre-operative assessment procedure of transcatheter aortic valve replacement (TAVR) would reduce the incident rate of peri-operative complications. Tradition manual segmentation is labor-intensive and low-efficient, which cannot meet the clinical demands of processing large data volumes. Recent developments in machine learning provided a viable way for accurate and efficient medical image segmentation for 3D patient-specific models automatically. This study quantitively evaluated the auto segmentation quality and efficiency of the four popular segmentation-dedicated three-dimensional (3D) convolutional neural network (CNN) architectures, including 3D UNet, VNet, 3D Res-UNet and SegResNet. All the CNNs were implemented in PyTorch platform, and low-dose CTA image sets of 98 anonymized patients were retrospectively selected from the database for training and testing of the CNNs. The results showed that despite all four 3D CNNs having similar recall, Dice similarity coefficient (DSC), and Jaccard index on the segmentation of the aortic root, the Hausdorff distance (HD) of the segmentation results from 3D Res-UNet is 8.56 ± 2.28, which is only 9.8% higher than that of VNet, but 25.5% and 86.4% lower than that of 3D UNet and SegResNet, respectively. In addition, 3D Res-UNet and VNet also performed better in the 3D deviation location of interest analysis focusing on the aortic valve and the bottom of the aortic root. Although 3D Res-UNet and VNet are evenly matched in the aspect of classical segmentation quality evaluation metrics and 3D deviation location of interest analysis, 3D Res-UNet is the most efficient CNN architecture with an average segmentation time of 0.10 ± 0.04 s, which is 91.2%, 95.3% and 64.3% faster than 3D UNet, VNet and SegResNet, respectively. The results from this study suggested that 3D Res-UNet is a suitable candidate for accurate and fast automatic aortic root segmentation for pre-operative assessment of TAVR.
Epigenetic mechanisms of Müller glial reprogramming mediating retinal regeneration
Authors: Si Tian-En , Li Zhixiao , Zhang Jingjing , Su Songxue , Liu Yupeng , Chen Shiyue , Peng Guang-Hua , Cao Jing , Zang Weidong
Published: June 2023

Retinal degenerative diseases, characterized by retinal neuronal death and severe vision loss, affect millions of people worldwide. One of the most promising treatment methods for retinal degenerative diseases is to reprogram non-neuronal cells into stem or progenitor cells, which then have the potential to re-differentiate to replace the dead neurons, thereby promoting retinal regeneration. Müller glia are the major glial cell type and play an important regulatory role in retinal metabolism and retinal cell regeneration. Müller glia can serve as a source of neurogenic progenitor cells in organisms with the ability to regenerate the nervous system. Current evidence points toward the reprogramming process of Müller glia, involving changes in the expression of pluripotent factors and other key signaling molecules that may be regulated by epigenetic mechanisms. This review summarizes recent knowledge of epigenetic modifications involved in the reprogramming process of Müller glia and the subsequent changes to gene expression and the outcomes. In living organisms, epigenetic mechanisms mainly include DNA methylation, histone modification, and microRNA–mediated miRNA degradation, all of which play a crucial role in the reprogramming process of Müller glia. The information presented in this review will improve the understanding of the mechanisms underlying the Müller glial reprogramming process and provide a research basis for the development of Müller glial reprogramming therapy for retinal degenerative diseases.
Resistance and virulence gene analysis and molecular typing of Escherichia coli from duck farms in Zhanjiang, China
Authors: Luo Shuaishuai , Liao Cuiyi , Peng Jinju , Tao Songruo , Zhang Tengyue , Dai Yue , Ding Yuexia , Ma Yi
Published: June 2023

Introduction

The widespread use of antibiotics in animal agriculture has increased the resistance of Escherichia coli, and pathogenic E. coli often harbor complex virulence factors. Antimicrobial resistance in pathogenic bacteria can cause public health problems. Correlation analyses of the resistance, virulence, and serotype data from the pathogenic bacteria found on farms and in the surrounding environment can thus provide extremely valuable data to help improve public health management.

Methods

In this investigation, we have assessed the drug resistance and virulence genes as well as the molecular typing characteristics of 30 E. coli strains isolated from duck farms in the Zhanjiang area of China. Polymerase chain reaction was used to detect the drug resistance and virulence genes as well as serotypes, and whole-genome sequencing was used to analyze the multilocus sequence typing.

Results

The detection rates for the oqxA resistance gene and fimC virulence gene were highest (93.3%, respectively). There were no correlations between the drug resistance and virulence gene numbers in the same strain. The epidemic serotype was O81 (5/24), ST3856 was an epidemic sequence type, and strains I-9 and III-6 carried 11 virulence genes. The E. coli strains from the duck farms in the Zhanjiang area were thus found to have a broad drug resistance spectrum, various virulence genes, complex serotypes, and certain pathogenicity and genetic relationship.

Discussion

Monitoring the spread of pathogenic bacteria and the provision of guidance regarding the use of antibiotics in the livestock and poultry industries will be required in the future in the Zhanjiang area.
Atrial fibrillation: primary prevention, secondary prevention, and prevention of thromboembolic complications: part 1
Authors: Trohman Richard G. , Huang Henry D. , Sharma Parikshit S.
Published: June 2023

Atrial fibrillation (AF), is the most common sustained cardiac arrhythmia. It was once thought to be benign as long as the ventricular rate was controlled, however, AF is associated with significant cardiac morbidity and mortality. Increasing life expectancy driven by improved health care and decreased fertility rates has, in most of the world, resulted in the population aged ≥65 years growing more rapidly than the overall population. As the population ages, projections suggest that the burden of AF may increase more than 60% by 2050. Although considerable progress has been made in the treatment and management of AF, primary prevention, secondary prevention, and prevention of thromboembolic complications remain a work in progress. This narrative review was facilitated by a MEDLINE search to identify peer-reviewed clinical trials, randomized controlled trials, meta-analyses, and other clinically relevant studies. The search was limited to English-language reports published between 1950 and 2021. Atrial fibrillation was searched via the terms primary prevention, hyperthyroidism, Wolff-Parkinson-White syndrome, catheter ablation, surgical ablation, hybrid ablation, stroke prevention, anticoagulation, left atrial occlusion and atrial excision. Google and Google scholar as well as bibliographies of identified articles were reviewed for additional references. In these two manuscripts, we discuss the current strategies available to prevent AF, then compare noninvasive and invasive treatment strategies to diminish AF recurrence. In addition, we examine the pharmacological, percutaneous device and surgical approaches to prevent stroke as well as other types of thromboembolic events.
Single-center initial experience with inner-branch complex EVAR in 44 patients
Authors: Kapalla Marvin , Busch Albert , Lutz Brigitta , Nebelung Heiner , Wolk Steffen , Reeps Christian
Published: June 2023

Purpose

The use of inner-branch aortic stent grafts in the treatment of complex aortic pathologies aims at broad applicability and stable bridging stent sealing compared to other endovascular technologies. The objective of this study was to evaluate the early outcomes with a single manufacturer custom-made and off-the-shelf inner-branched endograft in a mixed patient cohort.

Methods

This retrospective, monocentric study between 2019 and 2022 included 44 patients treated with inner-branched aortic stent grafts (iBEVAR) as custom-made device (CMD) or off-the-shelf device (E-nside) with at least four inner branches. The primary endpoints were technical and clinical success.

Results

Overall, 77% (n = 34) and 23% (n = 10) of the patients (mean age 77 ± 6.5 years, n = 36 male) were treated with a custom-made iBEVAR with at least four inner branches and an off-the-shelf graft, respectively. Treatment indications were thoracoabdominal pathologies in 52.2% (n = 23), complex abdominal aneurysms in 25% (n = 11), and type Ia endoleaks in 22.7% (n = 10). Preoperative spinal catheter placement was performed in 27% (n = 12) of patients. Implantation was entirely percutaneous in 75% (n = 33). Technical success was 100%. Target vessel success manifested at 99% (178/180). There was no in-hospital mortality. Permanent paraplegia developed in 6.8% (n = 3) of patients. The mean follow-up was 12 months (range 0–52 months). Three late deaths (6.8%) occurred, one related to an aortic graft infection. Kaplan–Meier estimated 1-year survival manifested at 95% and branch patency at 98% (177/180). Re-intervention was necessary for a total of six patients (13.6%).

Conclusions

Inner-branch aortic stent grafts provide a feasible option for the treatment of complex aortic pathologies, both elective (custom-made) and urgent (off-the-shelf). The technical success rate is high with acceptable short-term outcomes and moderate re-intervention rates comparable to existing platforms. Further follow-up will evaluate long-term outcomes.
Circulating miR-183-5p levels are positively associated with the presence and severity of coronary artery disease
Authors: Lv Dong , Guo Yanfu , Zhang Li , Li Xia , Li Guangping
Published: June 2023

Background

Serum miR-183-5p levels are associated with carotid atherosclerosis, while less is known about the relationship between circulating miR-183-5p levels and stable coronary artery disease (CAD).

Methods

In this cross-sectional study, consecutive patients with chest pain who underwent coronary angiograms from January 2022 to March 2022 at our center were enrolled. Those presenting acute coronary syndrome or had a prior CAD were excluded. Clinical presentations, laboratory parameters, and angiographic findings were collected. Serum miR-183-5p levels were measured using quantitative real-time polymerase chain reaction. CAD severity was displayed as the number of diseased vessels and further evaluated by the Gensini score system.

Results

Overall, 135 patients (median age, 62.0 years; male, 52.6%) were included in the present study. Stable CAD was identified in 85.2% of the study population, with 45.9% having 1-vessel disease, 21.5% having 2-vessel disease, and 17.8% having 3-vessel or left main disease. Serum miR-183-5p levels were significantly increased in CAD patients with different severities than non-CAD patients (all adjusted p < 0.05). Serum miR-183-5p levels increased as tertiles of the Gensini score progressed (all adjusted p < 0.05). Importantly, serum miR-183-5p levels could predict the presence of CAD and 3-vessel or left main disease in the receiver operating characteristic curve analysis (both p < 0.01), and also in multivariate analysis adjusting for age, sex, body mass index, diabetes, hypersensitive-C-reactive protein (both p < 0.05).

Conclusion

Serum miR-183-5p levels are independently and positively correlated with CAD presence and severity.
Auxological and endocrine findings in narcolepsy type 1: seventeen-year follow-up from a pediatric endocrinology center
Authors: Casale Sara , Assirelli Valentina , Pizza Fabio , Balsamo Antonio , Gennari Monia , Pession Andrea , Plazzi Giuseppe , Cassio Alessandra
Published: June 2023

Introduction

Narcolepsy Type 1 (NT1) is a rare hypersomnia of central origin linked to hypocretin deficiency, most frequently arising at pediatric age. NT1 could be associated with endocrine comorbidities involving the neuroendocrine axis, predominantly obesity, and Central Precocious Puberty (CPP). The primary aim of this study is the evaluation of endocrine and auxological parameters at diagnosis and during follow-up in patients with NT1, treated with Sodium Oxybate (SO) or not.

Methods

We retrospectively evaluated the auxological, biochemical, and radiological parameters of 112 patients referred to our Center between 2004-2022. The design of our study is cross-sectional at the time of diagnosis followed by a longitudinal follow-up.

Results

Our study confirms an increased frequency of CPP and obesity in patients with NT1. At first evaluation, obesity was found in 31.3% of patients, while overweight was found in 25.0%. A diagnosis of CPP was made in 19.6% of patients. Interestingly, this group showed a significantly lower level of CSF-hypocretin (hrct-1) at diagnosis compared to others. We found an improvement in BMI SDS in the SO-treated group compared to untreated patients, and this trend persisted also at 36 months of follow-up (0.0 ± 1.3 vs 1.3 ± 0.4; p<0.03). Sixty-three patients reached their final height, with a median SDS of 0.6 ± 1.1 in boys and 0.2 ± 1.2 in girls.

Discussion

To our knowledge, these are the first results regarding the final height in a large series of pediatric patients with NT1, with a normal range of IGF1-SDS levels and stature SDS.
The evaluation and optimization method of major events-driven polluted coastal zone renewal: a case of the polluted coastal zone in the Dalian Barracuda Bay Stadium Area
Authors: Gu Meng , Guo Qi , Yang Kexin , Jiang Bin , Yu Yang
Published: June 2023

Introduction: Coastal zone pollution leads directly to a series of local ecological, economic, and social damages. The renewal of polluted coastal zones is a comprehensive challenge that includes the degeneration of ecological services, the decrease in urban livability, and the increase in maintenance costs. Since current ecological management pays more attention to relevant technologies and investments, it plays a limited role in effectively and quickly executing the renewal of polluted coastal zones. Nature-based solutions (NbS) aim to improve regional ecological restoration and renewal by balancing multiple interests such as ecology, economy, and society. Therefore, NbS is an effective way to address this comprehensive challenge. Current studies on NbS are actively exploring the theoretical framework and practice process of solving complex social challenges through an ecological approach.

Methods: As an implanted production process, major events could provide robust policy support and continuous economic backing, which makes this an effective solution for challenges such as a lack of support and ineffective guarantees. This paper was centered around the goal of NbS theory, which is achieving comprehensive benefits, and establishing the Social-Economic-Ecological Systems framework (SEESs) that is driven by major events to achieve the renewal of polluted coastal zones.

Results: The main objective of this study was to investigate the renewal-driving potential of major events in facilitating the restoration (renewal) of coastal ecosystems from the perspective of NbS. Specifically, it aimed to explore how major events promote the renewal of polluted coastal zones, thereby fostering local socioeconomic advancements and enabling regional sustainable development. Driven by hosting the 2023 China Asian Cup, the renewal of the polluted coastal zone in the area around Dalian Barracuda Bay Stadium was studied. Three subsystems and 12 indexes were selected as evaluation indexes of polluted coastal zone renewal driven by major events. Furthermore, using the entropy weight method, we constructed an evaluation system of polluted coastal zone renewal benefits driven by major events, then verified the synergistic effect of the major event on the social, economic, and ecological recovery of the polluted coastal zone. Moreover, we evaluated the change in the comprehensive scores of the polluted coastal zone from 2018 to 2021 under the impact of the 2023 Asian Cup. The spatial and temporal patterns of each subsystem and index were also discussed.

Discussion: Finally, we proposed methods for the optimization of the renewal of urban coastal zone pollution driven by major events and provide solutions to cope with the negative impact of epidemics, strikes, and war throughout the process.
Investigation among students’ and teachers’ perception of climate health awareness regarding low carbon ecofriendly practices
Authors: Natalia Maryam , Ullah Waheed , Khan Ahsan Riaz , Wahid Abdul , Mehmood Muhammad Sajid , Naz Madeeha
Published: June 2023

Introduction: Global climate change has become rapidly one of humanity’s most pressing environmental concerns. To overcome this issue, public environmental awareness, sustainable behavior and understanding must be increased.

Method: So, this study explored the awareness of climate change, perception and attitude towards nature, impacts, effects, hopes, responsibility and engagement in low carbon behavior among students (n = 500) and faculty members (n = 50) from universities in Multan city. Data was collected using questionnaire from non-environmental science departments (n = 6). Descriptive statistics and Pearson correlation were used to compile the results.

Findings: Results concluded that awareness of climate change is higher in teachers than students. Both respondents showed similar responses regarding their perception of issues, and impacts but showed discrepancy while selecting effects of climate change. Participants’ attitudes towards the environment and hope for mitigation are similar. Students and teachers believed that every sector has major responsibility except teachers agreed on full individual responsibility and international organization has a small portion of responsibility. Both participants showed no interest in engagement in low carbon activities.

Conclusion: It is imperative that colleges and universities invest in educational programs and sustainability initiatives in order to shape the attitudes and behaviors of students and faculty members towards environmental sustainability.
Spatial-temporal evolution and motivation of ecological vulnerability based on RSEI and GEE in the Jianghan Plain from 2000 to 2020
Authors: Yi Siqi , Zhou Yong , Zhang Junda , Li Qing , Liu Yingying , Guo Yuting , Chen Yaqi
Published: June 2023

Recent urbanization and growing food consumption have had a severely detrimental effect on the ecological environment of the Jianghan Plain. The ecological fragility of the Jianghan Plain must be continually monitored for environmental conservation and sustainable development. This study utilized principal component analysis (PCA) to quantitatively assess the ecological vulnerability of the Jianghan Plain based on the remote sensing ecological index (RSEI) and analyzed the space-time changes and drivers in the Jianghan Plain from 2000 to 2020 using the Google Earth Engine Platform (GEE). The findings of this research indicated that the ecological vulnerability of the Jianghan Plain from 2000 to 2020 was predominantly Moderate or Strong level. But still, the EVI displayed a changing decreasing trend, revealing a small development towards a healthier ecological environment. The most significant ecological vulnerability deterioration occurred between 2005 and 2010, accounting for roughly 44.90 percent, whereas the highest improvement occurred between 2000 and 2005, occupying approximately 37.52% of the area. Moran’s I of EVI was greater than 0 in Jianghan Plain and displayed a growing and subsequently a falling trend, representing that the spatial distribution of regional ecological vulnerability was strongly correlated and aggregated and that the degree of aggregation has declined. The effects of heat, greenness, wetness, and dryness on the ecological vulnerability of Jianghan Plain were all significant, with greenness and wetness being the primary determinants of the change in Jianghan Plain’s ecological vulnerability. The results of this study can offer a theoretical and scientific foundation for ecological protection and restoration in the Jianghan Plain. Meanwhile, this study also provides a practical and rapid method for monitoring regional ecological vulnerability using RSEI, GEE, and PCA, which can be applied elsewhere for ecological vulnerability evaluation.
Experimental research on the flow law of the grouting fluid in an annular gap between a non-soil-squeezing PHC pipe pile wall and a hole wall
Authors: Zhenkun Hou , Zhanlin Li , Zejun Han , Mengxiong Tang , Yupeng Liu , Dingli Su , Lei Wang
Published: June 2023

The bearing capacity of drilling with pre-stressed concrete pile cased pile (hereafter referred to as DPC pile) is closely related to the grouting effect on an annular gap between a pre-stressed high-strength concrete (PHC) pipe pile wall and a hole wall (hereafter referred to as the an annular pile–soil gap). A physical grouting model testing system for the DPC pile based on a high-precision three-dimensional (3D) scanner and a multi-functional grouting box has been independently developed. In this method, 3D geometric size and spatial point information of the grouting stone have been quantitatively characterized. The influences of the water–cement ratio, grouting pressure, collapsed holes, and falling sand have been studied. The conclusions are obtained as follows: (1) a quantitative characterization method of the 3D geometric dimensions of the grouting stone based on a 3D scan is accurate and reliable and can overcome the shortcomings of traditional manual measurement. (2) In the same horizontal plane, grouting body thickness gradually decreases as its horizontal distance from the grouting outlet increases, and the higher the elevation, the greater the rate of decrease; conversely, the lower the elevation, the slower the rate of decrease. When the horizontal distance from the pulp outlet is equal, slurry thickness gradually decreases as the height increases. (3) For the grouting liquid with a water–cement ratio of 0.5, grouting pressure should not be less than 0.6 MPa. (4) When the falling sand is not far above the grouting outlet, a grouting root system can be formed, whose grout veins, complexity, and grout coverage area can be optimally improved by changing the fluidity of the grout and grouting pressure. When the falling sand is on the side of the grouting outlet or the surface of the grouting outlet but far away from the grouting outlet, it is easy to be avoided by the grout, which can greatly reduce the grouting effect.