bluuebunny/crossref_metadata_2025 huggingface dataset:
Improving Neutralization Potency and Breadth by Combining Broadly Reactive HIV-1 Antibodies Targeting Major Neutralization Epitopes
Authors: Kong Rui , Louder Mark K. , Wagh Kshitij , Bailer Robert T. , deCamp Allan , Greene Kelli , Gao Hongmei , Taft Justin D. , Gazumyan Anna , Liu Cassie , Nussenzweig Michel C. , Korber Bette , Montefiori David C. , Mascola John R.
Published: December 2014

The isolation of broadly neutralizing HIV-1 monoclonal antibodies (MAbs) to distinct epitopes on the viral envelope glycoprotein (Env) provides the potential to use combinations of MAbs for prevention and treatment of HIV-1 infection. Since many of these MAbs have been isolated in the last few years, the potency and breadth of MAb combinations have not been well characterized. In two parallel experiments, we examined the
in vitro
neutralizing activities of double-, triple-, and quadruple-MAb combinations targeting four distinct epitopes, including the CD4-binding site, the V1V2-glycan region, the V3-glycan supersite, and the gp41 membrane-proximal external region (MPER), using a panel of 125 Env-pseudotyped viruses. All MAb combinations showed substantially improved neutralization breadth compared to the corresponding single MAbs, while the neutralization potency of individual MAbs was maintained. At a 50% inhibitory concentration (IC
50
) cutoff of 1 μg/ml per antibody, double-MAb combinations neutralized 89 to 98% of viruses, and triple combinations neutralized 98 to 100%. Overall, the improvement of neutralization breadth was closely predicted by an additive-effect model and explained by complementary neutralization profiles of antibodies recognizing distinct epitopes. Subtle but consistent favorable interactions were observed in some MAb combinations, whereas less favorable interactions were observed on a small subset of viruses that are highly sensitive to V3-glycan MAbs. These data demonstrate favorable
in vitro
combinations of broadly neutralizing HIV-1 MAbs and suggest that such combinations could have utility for HIV-1 prevention and treatment.

IMPORTANCE
Over the last 5 years, numerous broadly reactive HIV-1-neutralizing MAbs have been isolated from B cells of HIV-1-infected donors. Each of these MAbs binds to one of the major vulnerable sites (epitopes) on the surface of the viral envelope glycoprotein. Since antibodies to distinct viral epitopes could theoretically act together to provide greater potency and breadth of virus neutralization, we tested physical mixtures of double, triple, and quadruple combinations of neutralizing MAbs targeting four major epitopes on HIV-1 Env. When tested together, antibody combinations showed substantially improved neutralization breadth compared to single MAbs. This improvement could be explained by the complementary neutralization profiles of individual MAbs. We further demonstrated that each antibody maintained its full neutralization potency when used in combination with other MAbs. These data provide a rationale for clinical use of antibody-based combinations for HIV-1 prevention and therapy.
Bilateral otorrhagia: a rare complication of laparoscopic abdominopelvic surgery
Authors: Addison Alfred Bentsi , Inarra Esther , Watts Simon
Published: December 2014

An 80-year-old woman without any previous otological symptoms underwent laparoscopic abdominoperineal resection for T3N0M0 low rectal carcinoma 4–5 cm from the anal verge. The total operative time was 6 h, of which she spent long hours in the Trendelenburg (35°) position due to difficult pelvic dissection. Midway through the procedure, she developed spontaneous non-traumatic bilateral otorrhagia. This case highlights the potential risk of increased intracranial pressure during prolonged periods of being in a steep Trendelenburg position caused either by the position itself or in combination with carbon dioxide pneumoperitoneum. We also consider the effect of a sudden change from this position to supine as a potential risk.
Epidural abscess secondary to acute appendicitis
Authors: Carter Marguerite , Meshkat Babek , El-Masry Sherif
Published: December 2014

A 62-year-old man presented via the emergency department with a 1-week history of back pain, on a background of non-insulin-dependent diabetes mellitus and rectal carcinoma for which he had undergone abdominoperineal resection, chemotherapy and radiotherapy. He exhibited signs of sepsis, midline lumbar spine tenderness and reduced hip flexion. CT of the abdomen and pelvis showed a presacral collection contiguous with the tip of the appendix, and MRI lumbar spine revealed abscess invation into the epidural space extending to T9. He underwent a laparotomy with washout of the presacral abscess and appendicectomy and prolonged course intravenous antibiotic therapy. At 3 months after initial presentation he had made a full clinical recovery with progressive radiological resolution of the epidural abscess. The objective of the case report is to highlight a unique and clinically significant complication of a very common pathology (appendicitis) and to briefly discuss other intra-abdominal sources of epidural abscess.
A population-based study of premature mortality in relation to neighbourhood density of alcohol sales and cheque cashing outlets in Toronto, Canada
Authors: Matheson Flora I , Creatore Maria Isabella , Gozdyra Piotr , Park Alison L , Ray Joel G
Published: December 2014

Objective

Alcohol overuse and poverty, each associated with premature death, often exist within disadvantaged neighbourhoods. Cheque cashing places (CCPs) may be opportunistically placed in disadvantaged neighbourhoods, where customers abound. We explored whether neighbourhood density of CCPs and alcohol outlets are each related to premature mortality among adults.

Design

Retrospective population-based study.

Setting

140 neighbourhoods in Toronto, Ontario, 2005–2009.

Participants

Adults aged 20–59 years.

Measures

Our primary outcome was premature all-cause mortality among adults aged 20–59 years. Across neighbourhoods we explored neighbourhood density, in km2, of CCPs and alcohol outlets, and the relation of each to premature mortality. Poisson regression provided adjusted relative risks (aRRs) and 95% CIs, adjusting for material deprivation quintile (Q), crime Q and number of banks.

Results

Intentional self-harm, accidental poisoning and liver disease were among the top five causes of premature death among males aged 20–59 years. The overall premature mortality rate was 96.3/10 000 males and 55.9/10 000 females. Comparing the highest versus lowest CCP density Q, the aRR for death was 1.25 (95% CI 1.15 to 1.36) among males and 1.11 (95% CI 0.99 to 1.24) among females. The corresponding aRR comparing the highest Q versus lowest Q alcohol outlet density in relation to premature mortality was 1.36 (95% CI 1.25 to 1.48) for males and 1.11 (95% CI 1.00 to 1.24) for females. The pattern of the relation between either CCPs or alcohol outlet density and premature mortality was typically J shaped.

Conclusions

There is a J-shaped relation between CCP or alcohol outlet density and premature mortality, even on controlling for conventional measures of poverty. Formal banking and alcohol reduction strategies might be added to health promotion policies aimed at reducing premature mortality in highly affected neighbourhoods.
Canine and feline obesity: a One Health perspective
Authors: Sandøe Peter , Palmer Clare , Corr Sandra , Astrup Arne , Bjørnvad Charlotte Reinhard
Published: December 2014

Recent years have seen a drastic increase in the rates of overweight and obesity among people living in some developed nations. There has also been increased concern over obesity in companion animals. In the latest article in Veterinary Record 's series on One Health, Peter Sandøe and colleagues argue that the relationship between obesity in people and in companion animals is closer and more complex than previously thought, and that obesity should be treated as a One Health problem
Development of a constitutive model for a bedded argillaceous rock from triaxial and true triaxial tests
Authors: Nguyen T.S. , Le A.D.
Published: December 2014

In this work, a constitutive model that predicts the mechanical behaviour of Opalinus clay is developed. The model is based on the theory of plasticity, and takes into consideration the inherent anisotropy due to the existence of bedding planes, hardening behaviour before the peak strength, softening behaviour after the peak, and creep effects. The model was implemented into the equations of pseudostatic equilibrium to simulate the mechanical response of Opalinus clay during conventional triaxial tests (using cylindrical samples) and true triaxial tests (using cubic samples). The model satisfactorily reproduces the main physical processes that prevailed during those tests.
Development and maintenance of force and stiffness in airway smooth muscle
Authors: Lan Bo , Norris Brandon A. , Liu Jeffrey C.-Y. , Paré Peter D. , Seow Chun Y. , Deng Linhong
Published: December 2014

Airway smooth muscle (ASM) plays a central role in the excessive narrowing of the airway that characterizes the primary functional impairment in asthma. This phenomenon is known as airway hyper-responsiveness (AHR). Emerging evidence suggests that the development and maintenance of ASM force involves dynamic reorganization of the subcellular filament network in both the cytoskeleton and the contractile apparatus. In this review, evidence is presented to support the view that regulation of ASM contraction extends beyond the classical actomyosin interaction and involves processes within the cytoskeleton and at the interfaces between the cytoskeleton, the contractile apparatus, and the extracellular matrix. These processes are initiated when the muscle is activated, and collectively they cause the cytoskeleton and the contractile apparatus to undergo structural transformation, resulting in a more connected and solid state that allows force generated by the contractile apparatus to be transmitted to the extracellular domain. Solidification of the cytoskeleton also serves to stiffen the muscle and hence the airway. Oscillatory strain from tidal breathing and deep inspiration is believed to be the counter balance that prevents hypercontraction and stiffening of ASM in vivo. Dysregulation of this balance could lead to AHR seen in asthma.
Neural Correlates of Mathematical Problem Solving
Authors: Lin Chun-Ling , Jung Melody , Wu Ying Choon , She Hsiao-Ching , Jung Tzyy-Ping
Published: December 2014

This study explores electroencephalography (EEG) brain dynamics associated with mathematical problem solving. EEG and solution latencies (SLs) were recorded as 11 neurologically healthy volunteers worked on intellectually challenging math puzzles that involved combining four single-digit numbers through basic arithmetic operators (addition, subtraction, division, multiplication) to create an arithmetic expression equaling 24. Estimates of EEG spectral power were computed in three frequency bands — θ (4–7 Hz), α (8–13 Hz) and β (14–30 Hz) — over a widely distributed montage of scalp electrode sites. The magnitude of power estimates was found to change in a linear fashion with SLs — that is, relative to a base of power spectrum, theta power increased with longer SLs, while alpha and beta power tended to decrease. Further, the topographic distribution of spectral fluctuations was characterized by more pronounced asymmetries along the left–right and anterior–posterior axes for solutions that involved a longer search phase. These findings reveal for the first time the topography and dynamics of EEG spectral activities important for sustained solution search during arithmetical problem solving.
A Fast and Stable Forecasting Model to Forecast Power Load
Authors: Tan Li-Zhi , Ouyang A.-J. , Peng Xu-Yu , Li Er-Xi , Truong Tung Khac , Hao Libo
Published: December 2014

As the traditional gray forecasting model GM(1, 1) has poor performance in forecasting the fast-growing power load, we present a chaotic co-evolutionary particle swarm optimization (CCPSO) algorithm, one with better efficiency than the PSO algorithm. Based on the GM(1, 1) model, the CCPSO algorithm is adopted to solve the values of parameters a and b in GM(1, 1) model. This is how the way we come up with the CCPSO algorithm-based GM. As can be seen from experimental results of case simulation on the power consumption in three regions, the CCPSO-GM model is better than the other four forecasting models, which attests its wide applicability and high forecasting accuracy.
Ettore Majorana: The scientist and the man
Authors: Recami Erasmo
Published: December 2014

Ettore Majorana was the brightest Italian theoretical physicist of the XX century (actually, Enrico Fermi regarded him as the brightest in the world of his time, and compared him to Galileo and Newton), even if to some people Majorana is often known mainly for his mysterious disappearance, in 1938, when he was 31. In this paper, we present a panoramic view of the main scientific articles published by him, as well as their significance. We also briefly outline his life, the biographical data being based on letters, documents, testimonies discovered or collected by the author during more than four decades, and contained since 1986 in Recami's book quoted in the text. Finally, extensive information and comments are added with regard to the scientific manuscripts left unpublished by Majorana. Two pictures complete the paper.
Inconsistency-Tolerant Multi-Agent Calculus
Authors: Kamide Norihiro
Published: December 2014

Verifying and specifying multi-agent systems in an appropriate inconsistency-tolerant logic are of growing importance in Computer Science since computer systems are generally used by or composed of inconsistency-tolerant multi-agents. In this paper, an inconsistency-tolerant logic for representing multi-agents is introduced as a Gentzen-type sequent calculus. This logic (or calculus) has multiple negation connectives that correspond to each agent, and these negation connectives have the property of paraconsistency that guarantees inconsistency-tolerance. The logic proposed is regarded as a modified generalization of trilattice logics, which are known to be useful for expressing fine-grained truth-values in computer networks. The completeness, cut-elimination and decidability theorems for the proposed logic (or sequent calculus) are proved as the main results of this paper.
Reconstruction of sequence from its circular partial sums for cyclopeptide sequencing problem
Authors: Fomin Eduard
Published: December 2014

In this paper, we consider the cyclopeptide sequencing problem that arose in computational biology with regard to de novo peptide sequencing in the 2000s. The sequencing problem for cyclic peptides is reduced in mathematics to the one-dimensional beltway problem: given a set of all circular pairwise distances between points, find the coordinates of these points. The beltway problem is one of the few fundamental problems that are neither known to be NP-complete nor solvable by polynomial-time algorithms. We develop an efficient algorithm for the cyclopeptide sequencing problem. The algorithm exploits information on possible elements of sequence and, thus, it makes it possible to restore sequences of lengths up to 160 elements. Numerical simulations sustain the effectiveness of the proposed algorithm.
New Nanosilver/Ceria Catalyst for Atmospheric Pollution Treatment
Authors: Benaissa S. , Chérif-Aouali L. , Siffert S. , Aboukais A. , Cousin R. , Bengueddach A.
Published: December 2014

Mesoporous CeO 2 was synthesized by the nanocasting pathway using the mesoporous SBA-15 silica as structure template and cerium nitrate as the CeO 2 precursor via a solid–liquid route. Ag / CeO 2 catalysts were prepared by three different methods: wetness impregnation (WI), deposition–precipitation with urea (DPU) and impregnation–reduction with citrate (IRC), with a loading of silver of 4 wt.%. They were characterized by elemental analysis, H2-TPR, X-ray powder diffraction (XRD), Brunauer, Emmett and Teller (BET) surface area, diffuse reflectance and ultraviolet visible spectroscopy (DR/UV-Vis). Ag / CeO 2 catalysts retain the physical properties of mesoporous ceria and its hexagonal order. Catalytic oxidation of propylene and catalytic reduction of NO with propylene as a reducing agent were investigated on Ag /mesoporous ceria catalysts. The silver/mesoporous ceria system toward the deep oxidation of propylene and the catalytic reduction of NO depends on the catalyst preparation method. Ag / CeO 2 (IRC) can be ascribed to higher surface lattice oxygen mobility over this catalyst and also to the strong interaction between silver and mesoporous ceria.
An in vitro investigation of photodynamic efficacy of FosPegⓇ on human colon cancer cells
Authors: Wu Ricky W. K. , Chu Ellie S. M. , Huang Zheng , Olivo Malini C. , Ip David C. W. , Yow Christine M. N.
Published: December 2014

Photodynamic therapy (PDT) is a novel therapeutic approach for combating various cancers. PDT involves the administration of a photosensitizer which generates singlet oxygen after light activation. FosPegⓇ is the liposomal formulation of mTHPC. In this in vitro study, the photodynamic efficacy of FosPegⓇ on a human colon cancer cell line (HT29) was investigated via studying the cellular uptake of FosPegⓇ, FosPegⓇ PDT mediated photocytotoxicity and the cell death mechanism were triggered. FosPegⓇ PDT demonstrated its antitumor effect in a drug and light dose-dependent manner in HT-29 cells. Lethal dose (LD50) was achieved with 0.4 μg/mL of drug and 3 J/cm-2 of light dose. FosPegⓇ PDT triggered apoptotic cell death via activating caspase cascade and regulating cell cycle progression. In conclusion, FosPegⓇ-PDT is an effective measure to combat human colon cancer cells.
A quaternion-based simulation of multirotor dynamics
Authors: Artale Valeria , Milazzo Cristina L. R. , Ricciardello Angela
Published: December 2014

The main problem addressed in this paper is the quaternion-based trajectory control of a microcopter consisting of six rotors with three pairs of counter-rotating fixed-pitch blades, known as hexacopter. If the hypothesis of rigid body condition is assumed, the Newton–Euler equations describe the translational and rotational motion of the drone. The standard Euler-angle parametrization of three-dimensional rotations contains singular points in the coordinate space that can cause failure of both dynamical model and control. In order to avoid singularities, all the rotations of the microcopter are thus parametrized in terms of quaternions and an original proportional derivative (PD) regulator is proposed in order to control the dynamical model. Numerical simulations will be performed on symmetrical flight configuration, proving the reliability of the proposed PD control technique.
IMPLICATIONS OF AN R-SCAN FOR CHARM PHYSICS
Authors: KÜHN JOHANN H.
Published: December 2014

The impact of improved measurements of the cross section for electron-positron annihilation into hadrons in the charm threshold region is discussed. Two aspects are studied in detail: i.) A significant reduction of the experimental error of the electronic width of the narrow resonances J/ψ and ψ′ and of the continuum cross section from the open charm threshold up to 4.6 GeV will lead to a correspondingly improved determination of the charmed quark mass; ii) A high luminosity measurement with 24 pb-1 at three points and with a spacing of 2 MeV around [Formula: see text] may allow to observe the direct, resonant production of χc1.
LEPTON FLAVOUR VIOLATION BEYOND THE PRESENT LIMITS
Authors: CALIBBI LORENZO
Published: December 2014

The status of the theoretical predictions for processes with flavor violation in the charged lepton sector is discussed in the light of the recent determination of the reactor angle θ13, as well as the improved limit set by MEG on BR (μ → eγ).
DARK FORCES SEARCHES IN FIXED TARGET EXPERIMENTS
Authors: BATTAGLIERI M.
Published: December 2014

Searches for physics Beyond the Standard Model (BSM) can be carried out with precise and GeV-energy-range experiments. In many string theories, a Hidden Sector, decoupled to the SM, foresees the existence of a new massive boson, the A′ or heavy photon, that weakly couples to the electromagnetic current. A new particle with mass in the range of 1 MeV - 1 GeV could explain many astro-particle observations (e.g. positron excess seen by PAMELA and AMS experiments) and some anomalies not yet fully understood (e.g. muon g - 2 factor). The search for A′ has motivated intense experimental activities in almost every accelerator facility using different techniques: colliding beam, fixed target experiments, meson rare decays. Jefferson Lab, a world-leading nuclear physics laboratory, is planning a set of fixed target experiments aiming to discover the A′ or set new limits in its mass and coupling, with an unprecedented sensitivity and reach capability. In this contribution, after reviewing the physics case and some experimental evidences, I will report on the program of measurements planned at Jefferson Lab for the next years.
γγ-PHYSICS AT KLOE/KLOE-2
Authors: BABUSCI D. ,   on behalf of the KLOE-2 collaboration (D. Babusci, D. Badoni, I. Balwierz-Pytko, G. Bencivenni, C. Bini, C. Bloise, F. Bossi, P. Branchini, A. Budano, L. Caldeira Balkeståhl, G. Capon, F. Ceradini, P. Ciambrone, F. Curciarello, E. Czerwiński, E. Danè, V. De Leo, E. De Lucia, G. De Robertis, A. De Santis, P. De Simone, A. Di Domenico, C. Di Donato, R. Di Salvo, D. Domenici, O. Erriquez, G. Fanizzi, A. Fantini, G. Felici, S. Fiore, P. Franzini, A. Gajos, P. Gauzzi, G. Giardina, S. Giovannella, E. Graziani, F
Published: December 2014

Photon-photon interactions have been studied at the ϕ-factory DAΦNE with the detector KLOE operating the machine at [Formula: see text] GeV, without tagging of the final leptons. The results about the γγ → η process and the evidence for γγ → π0π0 production at low π0π0 invariant mass are reviewed. The process γγ → π0 will be studied at KLOE-2 running the machine at ϕ-peak thanks to new lepton tagger detectors. In particular, the possibility to measure the two-photon width of π0 and the π0γ*γ transition form factor in the low (space-like) Q2 region is considered.
THE LIGHT-BY-LIGHT CONTRIBUTION TO THE MUON (g - 2) WITHIN NONLOCAL CHIRAL QUARK MODEL
Authors: DOROKHOV A. E. , RADZHABOV A. E. , ZHEVLAKOV A. S.
Published: December 2014

The light-by-light contribution to the anomalous magnetic moment of muon is estimated in the framework of nonlocal quark model. The partial contribution from contact diagrams and mesonic exchanges is discussed.
FINAL STATE INTERACTION AND ANISOTROPY OF PAIR PRODUCTION CLOSE TO THRESHOLD IN e+e- ANNIHILATION
Authors: DMITRIEV V. F. , MILSTEIN A. I.
Published: December 2014

The final state interaction in the processes [Formula: see text] and [Formula: see text] close to the threshold is discussed. It is shown that, due to the Coulomb interaction, the contribution of the d wave to the cross section does not vanish even at zero relative velocity of produced particles. This results in the nonzero anisotropy in angular distribution at the threshold. We use the Paris nucleon-antinucleon optical potential for explanation of experimental data in the process [Formula: see text] near threshold. It follows from our consideration that the isoscalar form factor is much larger than the isovector one.
HADRONIC VACUUM POLARISATION IN g - 2 AND αQED
Authors: TEUBNER THOMAS
Published: December 2014

The status of the hadronic vacuum polarisation contributions to g - 2 of the muon and to the running QED coupling is briefly reviewed. The role of recent hadronic cross section measurements and remaining puzzles are discussed.
PHYSICS PROGRAM WITH A LOW ENERGY e+e-, e-γ, γγ COLLIDER AND ELECTRON BEAM ON TARGET AT IRIDE
Authors: FERRARIO MASSIMO , VENANZONI GRAZIANO ,   for the IRIDE Collaboration
Published: December 2014

We will discuss the particle physics opportunities at IRIDE (Interdisciplinary Research Infrastructure based on a Dual Electron Linac et Laser), a new multipurpose facility based on a combination of a high duty cycle radio-frequency superconducting electron linac (SC RF LINAC) and of high energy laser, presently under consideration at INFN.
MESON SPECTROSCOPY AT JLAB AT 12 GEV
Authors: FEGAN STUART
Published: December 2014

The 12 GeV upgrade to the Continuous Electron Beam Accelerator Facility (CEBAF) at Jefferson Lab will enable a new generation of experiments in hadronic nuclear physics, seeking to address fundamental questions in our understanding of QCD. The existence of exotic states, suggested by both quark models and lattice calculations, would allow gluonic degrees of freedom to be explored, and may help explain the role played by gluons in the QCD interaction. This article will review the meson spectroscopy program being planned at the lab following the 12 GeV upgrade, utilising real and quasi-real photon beams in two of the lab's four experimental halls, whose distinct capabilities will enable an extensive set of spectroscopy experiments to be performed at the same facility.
CHARM: MIXING, CP VIOLATION AND RARE DECAYS AT LHCb
Authors: ALEXANDER MICHAEL ,   On behalf of the LHCb Collaboration
Published: December 2014

Recent results on mixing, CP violation and rare decays in charm physics from the LHCb experiment are presented. Study of "wrong-sign" D0 → K+π- decays provides the highest precision measurements to date of the mixing parameters x′2 and y′, and of CP violation in this decay mode. Direct and indirect CP violation in the D0 system are probed to a sensitivity of around 10-3 using D0 → K+K− and D0 → π+π− decays and found to be consistent with zero. Searches for the rare decays [Formula: see text], [Formula: see text] and D0 → μ+μ− find no evidence of signal, but set the best limits on branching fractions to date. Thus, despite many excellent results in charm physics from LHCb, no evidence for physics beyond the Standard Model is found.
RESULTS AND PERSPECTIVES ON NUCLEON FORM FACTORS FROM SND AND CMD-3
Authors: ACHASOV M. N. , AKHMETSHIN R. R. , ANISENKOV A. V. , AULCHENKO V. M. , BANZAROV V. S. , BARKOV L. M. , BARNYAKOV A. YU. , BASHTOVOY N. S. , BELOBORODOV K. I. , BERDYUGIN A. V. , BERKAEV D. E. , BOGDANCHIKOV A. G. , BONDAR A. E. , BOTOV A. A. , BRAGIN A. V. , DIMOVA T. V. , DRUZHININ V. P. , EIDELMAN S. I. , EPIFANOV D. A. , EPSHTEYN L. B. , EROFEEV A. L. , FEDOTOVICH G. V. , GAYAZOV S. E. , GOLUBEV V. B. , GREBENUK A. A. , GREVTSOV K. A. , GRIGORIEV D. N. , GROMOV E. M. , IGNATOV F. V. , KARDAPOLTSEV L. V. , KARPOV S. V. , KAZANIN V. F. , KHARLAMOV A. G. , KHAZIN B. I. , KIRPOTIN A. N. , KOOP I. A. , KOROL A. A. , KOSHUBA S. V. , KOVALENKO O. A. , KOVRIZHIN D. P. , KOZYREV A. N. , KOZYREV E. A. , KROKOVNY P. P. , KUPICH A. S. , KUZMENKO A. E. , KUZMIN A. S. , LOGASHENKO I. B. , LUKIN P. A. , LYSENKO A. P. , MARTIN K. A. , MIKHAILOV K. YU. , OBRAZOVSKY A. E. , OKHAPKIN V. S. , PAKHTUSOVA E. V. , PEREVEDENTSEV E. A. , PESTOV YU. N. , POPOV A. S. , POPOV YU. S. , RAZUVAEV G. P. , ROGOVSKY YU. A. , ROMANOV A. L. , RUBAN A. A. , RYSKULOV N. M. , RYZHENENKOV A. E. , SEREDNYAKOV S. I. , SHATUNOV P. YU. , SHATUNOV YU. M. , SHEBALIN V. E. , SHEMYAKIN D. N. , SHTOL D. A. , SHWARTZ B. A. , SIBIDANOV A. L. , SILAGADZE Z. K. , SOLODOV E. P. , SURIN I. K. , TALYSHEV A. A. , TITOV V. M. , VASILJEV A. V. , VOROBIOV A. I. , YUDIN YU. V. , ZEMLYANSKY I. M. , ZHARINOV YU. M.
Published: December 2014

During years 2011 and 2012 data taking runs have been carried out at VEPP-2000 e+e- collider to measure the production of the nucleon-antinucleon pairs [Formula: see text] near threshold. In this talk the preliminary results on the nucleon timelike electromagnetic form factors (FF) and the |GE/GM| ratio are presented.
NUCLEON FORM FACTORS PROGRAM WITH SBS AT JLAB
Authors: WOJTSEKHOWSKI BOGDAN
Published: December 2014

The physics of the nucleon form factors is the basic part of the Jefferson Laboratory program. We review the achievements of the 6-GeV era and the program with the 12-GeV beam with the SBS spectrometer in Hall A, with a focus on the nucleon ground state properties.
HEAVY QUARK SPECTROSCOPY AT LHCb
Authors: EIDELMAN SIMON ,   for the LHCb Collaboration
Published: December 2014

We report recent results related to spectroscopy of heavy quarks obtained with the LHCb detector. They include a study of the X(3872) produced in continuum and B decays, precise measurements of the D and Ds masses, a study of the properties of DJ mesons and excited Bs states as well as the first observation of the [Formula: see text] decay.
STATUS AND PROSPECTS OF THE MUONIUM EXPERIMENT AT J-PARC
Authors: TORII H. A. , TANAKA K. S. , TAJIMA M. , MIZUTANI T. , MATSUDA Y. , FUKAO Y. , IINUMA H. , IKEDO Y. , KADONO R. , KAWAMURA N. , KODA A. , KOJIMA K. , MIBE T. , MIYAKE Y. , NAGAMINE K. , NISHIYAMA K. , OHKUBO R. , OGITSU T. , SAITO N. , SASAKI K. , SHIMOMURA K. , STRASSER P. , SUGANO M. , TOYODA A. , UENO K. , YAMAMOTO A. , YOSHIDA M. , ISHIDA K. , IWASAKI M. , KAMIGAITO O. , KANDA S. , TOMONO D. , UENO Y. , KUBO K. , AOKI M. , TORIKAI E. , KAWALL D.
Published: December 2014

A microwave spectroscopy experiment of muonium atoms are being prepared at J-PARC in Japan, aiming at an improved relative precision at a level of 10-8 in determination of the muonic magnetic moment. A major improvement of statistical uncertainty is due to higher muon intensity of the pulsed beam at J-PARC, while further improvements are expected for systematic uncertainties. Reduction of sources of systematic uncertainties are being studied: those arising from microwave power fluctuations, magnetic field inhomogeneity, muon stopping distribution and gas-density shift of resonance frequencies. Status and prospects of studies and developments of the experiment is presented in this paper.
HIGH ACCURATE MEASUREMENT OF τ MASS AT BESIII
Authors: MO XIAOHU ,   on behalf of BESIII Collaboration
Published: December 2014

The new experiment at BESIII aims at the uncertainty less than 0.1 MeV, or 5.6 × 10-5 for the relative error. To make full use of machine time, the optimization study is performed to acquire the best strategy of data taking. The results of mτ based on the test scan sample at BESIII are presented.
RECENT RESULTS ON τ LEPTON PHYSICS FROM BELLE
Authors: EIDELMAN SIMON ,   for the Belle Collaboration
Published: December 2014

We report recent results on τ lepton physics obtained with the Belle detector. They include a search for lepton-flavor-violating decays τ → lhh′, a high-precision measurement of the τ lepton lifetime and a study of the hadronic decays with the [Formula: see text] in the final state.
PERTURBATIVE EXPANSION OF τ HADRONIC SPECTRAL FUNCTION MOMENTS
Authors: BOITO DIOGO
Published: December 2014

In the extraction of αs from hadronic τ decay data several moments of the spectral functions have been employed. Furthermore, different renormalization group improvement (RGI) frameworks have been advocated, leading to conflicting values of αs. Recently, we performed a systematic study of the perturbative behavior of these moments in the context of the two main-stream RGI frameworks: Fixed Order Perturbation Theory (FOPT) and Contour Improved Perturbation Theory (CIPT). The yet unknown higher order coefficients of the perturbative series were modelled using the available knowledge of the renormalon singularities of the QCD Adler function. We were able to show that within these RGI frameworks some of the commonly employed moments should be avoided due to their poor perturbative behavior. Furthermore, under reasonable assumptions about the higher order behavior of the perturbative series FOPT provides the preferred RGI framework.
LIGHT MESON SPECTROSCOPY AT KLOE/KLOE-2
Authors: MASCOLO MATTEO ,   on behalf of the KLOE-2 collaboration (D. Babusci, D. Badoni, I. Balwierz-Pytko, G. Bencivenni, C. Bini, C. Bloise, F. Bossi, P. Branchini, A. Budano, L. Caldeira Balkeståhl, G. Capon, F. Ceradini, P. Ciambrone, F. Curciarello, E. Czerwiński, E. Danè, V. De Leo, E. De Lucia, G. De Robertis, A. De Santis, P. De Simone, A. Di Domenico, C. Di Donato, R. Di Salvo, D. Domenici, O. Erriquez, G. Fanizzi, A. Fantini, G. Felici, S. Fiore, P. Franzini, A. Gajos, P. Gauzzi, G. Giardina, S. Giovannella, E. Graziani, F
Published: December 2014

The status of the main ongoing analyses on light-meson spectroscopy at KLOE are presented. In particular, the most recent upgrades for the ϕ → ηe+e- analysis, in both charged (η → π+π-π0) and neutral (η → π0π0π0) channels of η decay, as well as the preliminary studies of the ϕ → π0e+e- process are reported. Latest upgrades on η → π+π-π0 Dalitz plot analysis are also shown. All the analyses are based on data collected at DAΦNE collider with the KLOE detector during the 2004/2005 data taking campaign.
LIGHT MESON STUDIES WITH WASA-AT-COSY
Authors: HEIJKENSKJÖLD L. ,   for the WASA-at-COSY collaboration
Published: December 2014

Detailed experimental studies of the decays and interactions of light mesons, such as π0, η and ω, are highly needed as precision tests for theoretical models.

The Wide Angle Shower Apparatus (WASA) detector is one of the available experimental set-ups optimized for studying production and decays of light mesons. In contrast to the focus of this workshop, the mesons are produced through proton-proton or proton-deuteron collisions using a fixed target.

This paper will present status of studies performed by the WASA-at-COSY collaboration in the field of light meson interactions.
STUDY OF THE PROCESS e+e- → K+K-π+π- WITH THE CMD-3 DETECTOR AT THE VEPP-2000 e+e- COLLIDER
Authors: AKHMETSHIN R. R. , ANISENKOV A. V. , AULCHENKO V. M. , BANZAROV V. S. , BARKOV L. M. , BASHTOVOY N. S. , BERKAEV D. E. , BRAGIN A. V. , EIDELMAN S. I. , EPIFANOV D. A. , EPSHTEYN L. B. , EROFEEV A. L. , FEDOTOVICH G. V. , GAYAZOV S. E. , GREBENUK A. A. , GRIGORIEV D. N. , GROMOV E. M. , IGNATOV F. V. , KARPOV S. V. , KAZANIN V. F. , KHAZIN B. I. , KIRPOTIN A. N. , KOOP I. A. , KOVALENKO O. A. , KOZYREV A. N. , KOZYREV E. A. , KROKOVNY P. P. , KUZMENKO A. E. , KUZMIN A. S. , LOGASHENKO I. B. , LUKIN P. A. , LYSENKO A. P. , MIKHAILOV K. Yu. , OKHAPKIN V. S. , PESTOV Yu. N. , PEREVEDENTSEV E. A. , POPOV A. S. , POPOV Yu. S. , RAZUVAEV G. P. , ROGOVSKY Yu. A. , ROMANOV A. L. , RUBAN A. A. , RYSKULOV N. M. , RYZHENENKOV A. E. , SHEBALIN V. E. , SHEMYAKIN D. N. , SHWARTZ B. A. , SHWARTZ D. B. , SIBIDANOV A. L. , SHATUNOV P. Yu. , SHATUNOV Yu. M. , SOLODOV E. P. , TITOV V. M. , TALYSHEV A. A. , VOROBIOV A. I. , YUDIN Yu. V. , ZHARINOV Yu. M.
Published: December 2014

We report preliminary results on the measurement of the cross section of the process e+e- → K+K-π+π- in the c.m. energy range from 1.5 GeV to 2 GeV. It is shown that the cross section is dominated by the contributions of several intermediate states K+K-ρ, K*Kπ, ϕπ+π- and K*K*.
ON THE SPIN CORRELATIONS OF MUONS AND TAU LEPTONS GENERATED IN THE ANNIHILATION PROCESSES e+e- → μ+μ-, e+e- → τ+τ-
Authors: LYUBOSHITZ VALERY V. , LYUBOSHITZ VLADIMIR L.
Published: December 2014

Using the technique of helicity amplitudes, the electromagnetic process e+e- → μ+μ-(τ+τ-) is theoretically studied in the one-photon approximation. The structure of the triplet states of the final (μ+μ-) system is analyzed. It is shown that in the case of unpolarized electron and positron the final muons are also unpolarized, but their spins are strongly correlated. Explicit expressions for the components of the correlation tensor of the (μ+μ-) system are derived. The formula for the angular correlation at the decays of final muons μ+ and μ- is obtained. It is demonstrated that spin correlations of muons in the considered process have the purely quantum character, since one of the Bell-type incoherence inequalities for the correlation tensor components is always violated.
STATUS OF HADRONIC LIGHT-BY-LIGHT SCATTERING IN THE MUON g – 2
Authors: NYFFELER ANDREAS
Published: December 2014

We give an update on the status of the hadronic light-by-light scattering contribution to the muon g – 2. We review recent work, list some open problems and give an outlook on how to better control the uncertainty of this contribution. We think the estimate [Formula: see text] still gives a fair description of the current situation.
MEASUREMENT OF THE $e^+e^- \to p \bar{p}$ CROSS SECTION WITH THE CMD-3 DETECTOR AT VEPP-2000
Authors: AKHMETSHIN R. R. , ANISENKOV A. V. , AULCHENKO V. M. , BANZAROV V. S. , BARKOV L. M. , BASHTOVOY N. S. , BERKAEV D. E. , BRAGIN A. V. , EIDELMAN S. I. , EPIFANOV D. A. , EPSHTEYN L. B. , EROFEEV A. L. , FEDOTOVICH G. V. , GAYAZOV S. E. , GREBENUK A. A. , GRIGORIEV D. N. , GROMOV E. M. , IGNATOV F. V. , KARPOV S. V. , KAZANIN V. F. , KHAZIN B. I. , KIRPOTIN A. N. , KOOP I. A. , KOVALENKO O. A. , KOZYREV A. N. , KOZYREV E. A. , KROKOVNY P. P. , KUZMENKO A. E. , KUZMIN A. S. , LOGASHENKO I. B. , LUKIN P. A. , LYSENKO A. P. , MIKHAILOV K. Yu. , OKHAPKIN V. S. , PESTOV Yu. N. , PEREVEDENTSEV E. A. , POPOV A. S. , POPOV Yu. S. , RAZUVAEV G. P. , ROGOVSKY Yu. A. , ROMANOV A. L. , RUBAN A. A. , RYSKULOV N. M. , RYZHENENKOV A. E. , SHEBALIN V. E. , SHEMYAKIN D. N. , SHWARTZ B. A. , SHWARTZ D. B. , SIBIDANOV A. L. , SHATUNOV P. Yu. , SHATUNOV Yu. M. , SOLODOV E. P. , TITOV V. M. , TALYSHEV A. A. , VOROBIOV A. I. , YUDIN Yu. V. , ZHARINOV Yu. M.
Published: December 2014

We report preliminary results on the measurement of the [Formula: see text] cross section with the CMD-3 detector at the VEPP-2000 electron-positron collider based on 4.5 pb-1 of integrated luminosity collected in the c.m. energy range 1.92 - 2.0 GeV. Event selection using information from the Drift Chamber and Calorimeters provides a clean sample of [Formula: see text] events. The obtained results are in good agreement with the previous measurements.
Deep-water ostracods from the Middle Anisian (Reifling Formation) of the Northern Calcareous Alps (Austria)
Authors: Mette Wolfgang , Honigstein Avi , Crasquin Sylvie
Published: December 2014

Abstract. A diverse silicified ostracod aassemblage from Middle Anisian, Middle Triassic, intra-shelf basin deposits (Reifling Formation) is described. It comprises 32 species, of which 5 are new species (Bairdia biforis n. sp., B. schneebergiana n. sp., Mirabairdia praepsychrosphaerica n. sp., M. plurispinosa n. sp., Bairdiacypris aequisymmetrica n. sp.). The assemblage consists of both neritic species and deep-water taxa which have been considered as representatives of the ‘Thuringian Ecotype’ or the ‘Palaeopsychrospheric Fauna’. Lithofacies, palaeogeographical setting and taxonomic composition are suggestive of a deep neritic to upper bathyal depositional environment. ‘Archaic’ faunal elements are relatively rare and include the genera Spinomicrocheilinella and Processobairdia, which were formerly known only from the Palaeozoic and are now recorded for the first time from the Mesozoic.
Modelling fluid flow in Opalinus Clay excavation damage zone. A semi-analytical approach
Authors: Alcoverro J. , Olivella S. , Alonso E. E.
Published: December 2014

The HG-A
in situ test
, located at the Mont Terri Underground Rock Laboratory (URL), was analysed as part of the FORGE project. This test investigated the behaviour of the excavation damage zone (EDZ) around a backfilled microtunnel by a series of water- and gas-injection tests. Prior to testing, the backfilled microtunnel was sealed with a hydraulic megapacker system. A key aspect was the investigation of crack opening and closure along the EDZ in response to water and gas injections in the context of radioactive waste disposal. In the model, the intrinsic permeability of the EDZ was assumed to depend on deformation, and additional simplifying assumptions were considered: axisymmetry about the tunnel axis; no gravity; soil slices orthogonal to the tunnel axis move independently and in plane strain; liquid and gas flows along the EDZ parallel to the tunnel axis; and undrained saturated conditions for the Opalinus Clay. As a result, the field equations were reduced to differential equations for liquid and gas pressures defined in a one-dimensional (1D) domain representing the EDZ. The main trends of the pressure evolution observed in the test section were reproduced. A 2D axisymmetric model confirmed the validity of the simplifying assumptions, except for small zones of the EDZ near the megapacker ends.
Error Saturation Nonlinearities for Robust Incremental LMS over Wireless Sensor Networks
Authors: Panigrahi Trilochan , Panda Ganapati , Mulgrew Bernard
Published: December 2014

The data collected by sensor nodes over a geographical region is contaminated with Gaussian and impulsive noise. The conventional gradient-based distributed adaptive estimation algorithms exhibit good performance in the presence of Gaussian noise but perform poorly in impulsive noise environments. Therefore, the objective of this article is to propose a robust distributed adaptive algorithm that alleviates the effect of impulsive noise. An error saturation nonlinearity-based robust distributed strategy is proposed in an incremental cooperative network to estimate the desired parameters in impulsive noise. The steady-state analysis of the proposed error saturation nonlinearity incremental least mean squares (SNILMS) algorithm is carried out by employing the spatial-temporal energy conservation principle. Both theoretical and simulation results show that the presence of the error nonlinearity has made the proposed SNILMS algorithm robust to impulsive noise.
Mixing in Random Digraphs with Application to the Forward-Secure Key Evolution in Wireless Sensor Networks
Authors: Klonowski Marek , Kutyłowski Mirosław , Ren Michał , Rybarczyk Katarzyna
Published: December 2014

A key distribution scheme for wireless sensor networks based on a system of dynamic, pairwise keys is considered. In the scheme, each pair of communicating nodes shares pairwise symmetric keys and changes them at every transmission using a set of hashing functions. This article examines security aspects of the protocol. The most important issue is to ensure that it is infeasible for an adversary to restrict exhaustive key search to a subset of the keyspace. This desirable property holds if, after a small number of random key transitions, the distribution of keys among the nodes is close to uniform. The article provides a rigorous mathematical analysis of the distribution of keys and supplements it with experimental results. The problem is reduced to the question of determining mixing time and the stationary distribution of a random walk on a random digraph. It is shown that with probability close to 1, the mixing time is of small order and the fluctuations of the distribution are limited. This ensures the ongoing security of the protocol by making the communications forward secure and protecting against node compromise.
Mesenteric lymphatic vessels adapt to mesenteric venous hypertension by becoming weaker pumps
Authors: Dongaonkar R. M. , Nguyen T. L. , Quick C. M. , Heaps C. L. , Hardy J. , Laine G. A. , Wilson E. , Stewart R. H.
Published: December 2014

Lymphangions, the segments of lymphatic vessels between two adjacent lymphatic valves, actively pump lymph. Acute changes in transmural pressure and lymph flow have profound effects on lymphatic pump function in vitro. Chronic changes in pressure and flow in vivo have also been reported to lead to significant changes in lymphangion function. Because changes in pressure and flow are both cause and effect of adaptive processes, characterizing adaptation requires a more fundamental analysis of lymphatic muscle properties. Therefore, the purpose of the present work was to use an intact lymphangion isovolumetric preparation to evaluate changes in mesenteric lymphatic muscle mechanical properties and the intracellular Ca2+ in response to sustained mesenteric venous hypertension. Bovine mesenteric veins were surgically occluded to create mesenteric venous hypertension. Postnodal mesenteric lymphatic vessels from mesenteric venous hypertension (MVH; n = 6) and sham surgery (Sham; n = 6) animals were isolated and evaluated 3 days after the surgery. Spontaneously contracting MVH vessels generated end-systolic active tension and end-diastolic active tension lower than the Sham vessels. Furthermore, steady-state active tension and intracellular Ca2+ concentration levels in response to KCl stimulation were also significantly lower in MVH vessels compared with those of the Sham vessels. There was no significant difference in passive tension in lymphatic vessels from the two groups. Taken together, these results suggest that following 3 days of mesenteric venous hypertension, postnodal mesenteric lymphatic vessels adapt to become weaker pumps with decreased cytosolic Ca2+ concentration.
Functional importance of T-type voltage-gated calcium channels in the cardiovascular and renal system: news from the world of knockout mice
Authors: Hansen Pernille B. L.
Published: December 2014

Over the years, it has been discussed whether T-type calcium channels Cav3 play a role in the cardiovascular and renal system. T-type channels have been reported to play an important role in renal hemodynamics, contractility of resistance vessels, and pacemaker activity in the heart. However, the lack of highly specific blockers cast doubt on the conclusions. As new T-type channel antagonists are being designed, the roles of T-type channels in cardiovascular and renal pathology need to be elucidated before T-type blockers can be clinically useful. Two types of T-type channels, Cav3.1 and Cav3.2, are expressed in blood vessels, the kidney, and the heart. Studies with gene-deficient mice have provided a way to investigate the Cav3.1 and Cav3.2 channels and their role in the cardiovascular system. This review discusses the results from these knockout mice. Evaluation of the literature leads to the conclusion that Cav3.1 and Cav3.2 channels have important, but different, functions in mice. T-type Cav3.1 channels affect heart rate, whereas Cav3.2 channels are involved in cardiac hypertrophy. In the vascular system, Cav3.2 activation leads to dilation of blood vessels, whereas Cav3.1 channels are mainly suggested to affect constriction. The Cav3.1 channel is also involved in neointima formation following vascular damage. In the kidney, Cav3.1 regulates plasma flow and Cav3.2 plays a role setting glomerular filtration rate. In conclusion, Cav3.1 and Cav3.2 are new therapeutic targets in several cardiovascular pathologies, but the use of T-type blockers should be specifically directed to the disease and to the channel subtype.
Evolution of the oxygen sensitivity of cytochromecoxidase subunit 4
Authors: Kocha K. M. , Reilly K. , Porplycia D. S. M. , McDonald J. , Snider T. , Moyes C. D.
Published: December 2014

Vertebrates possess two paralogs of cytochrome c oxidase (COX) subunit 4: a ubiquitous COX4-1 and a hypoxia-linked COX4-2. Mammalian COX4-2 is thought to have a role in relation to fine-tuning metabolism in low oxygen levels, conferred through both structural differences in the subunit protein structure and regulatory differences in the gene. We sought to elucidate the pervasiveness of this feature across vertebrates. The ratio of COX4-2/4-1 mRNA is generally low in mammals, but this ratio was higher in fish and reptiles, particularly turtles. The COX4-2 gene appeared unresponsive to low oxygen in nonmammalian models (zebrafish, goldfish, tilapia, anoles, and turtles) and fish cell lines. Reporter genes constructed from the amphibian and reptile homologues of the mammalian oxygen-responsive elements and hypoxia-responsive elements did not respond to low oxygen. Unlike the rodent ortholog, the promoter of goldfish COX4-2 did not respond to hypoxia or anoxia. The protein sequences of the COX4-2 peptide showed that the disulfide bridge seen in human and rodent orthologs would be precluded in other mammalian lineages and lower vertebrates, all of which lack the requisite pair of cysteines. The coordinating ligands of the ATP-binding site are largely conserved across mammals and reptiles, but in Xenopus and fish, sequence variations may disrupt the ability of the protein to bind ATP at this site. Collectively, these results suggest that many of the genetic and structural features of COX4-2 that impart responsiveness and benefits in hypoxia may be restricted to the Euarchontoglires lineage that includes primates, lagomorphs, and rodents.