bluuebunny/crossref_metadata_2025 huggingface dataset:
A clinical case of hydatid echinococcosis in Perm Krai
Authors: Nikolenko V. V. , Belkina E. V. , Vorobieva N. N. , Teterin V. Yu. , Yakusheva M. V. , Nebolsina A. P.
Published: December 2023

The objective of the study was to analyze the clinical picture of hydatid echinococcosis with combined damage of the liver and lungs as well as tactics of management and treatment. A clinical observation of a patient with echinococcosis is presented. Information from the medical record of an inpatient with the results of clinical examination, instrumental and laboratory diagnostic methods was used. The clinical case is characterized by a delay in surgical intervention and a severe course of infection. The need for increased attention of practitioners to echinococcosis is indicated; an individual work with each patient to prevent a severe course, possible complications and a favorable outcome of the disease is required.
Papillary thyroid microcarcinoma: impossible to operate observe – where to put a comma?
Authors: Afanasyeva Z. A. , Vasilevskaya S. M. , Druzhkova N. B. , Сhernyshov V. A. , Saveliev V. V. , Khamzina F. T. , Muzafarova F. K. , Gazizov R. R. , Sabirov A. G.
Published: December 2023

Objective. To evaluate the efficiency of diagnostics and treatment in patients with microcarcinomas of the thyroid gland at the State Medical Institution "RCOD of the Ministry of Health of the Republic of Tatarstan named after Professor. M.Z. Sigal" for 2020-22.

Materials and methods. MIS "BARS. Healthcare – MIS" of oncological dispensary, outpatient charts and medical histories of patients operated on for thyroid microcarcinomas were used.

Results. In the study group, all patients had papillary microcarcinoma. Women over 45 years of age prevailed. Women of fertile age accounted for 41.7%. The combination of microcarcinoma with thyroid adenomas, colloidal goiter and AIT was detected in 78.6% of patients. The organ capsule invasion occurred in 35.7% of patients, metastases to regional lymph nodes – in 19%. Thyroidectomy was performed in 66.7% of patients; 12 (28.6%) patients underwent I-131 therapy.

Conclusions. Due to the fact that papillary microcarcinoma of the thyroid gland is often found in women of fertile age, and develops against the background of another thyroid pathology complicating diagnostics, it sprouts an organ capsule in 35.7% and gives metastases to regional lymph nodes in 19%, therefore requires a timely diagnostics and radical treatment.
Personalized therapy of type 2 diabetes mellitus
Authors: Kiseleva T. A. , Valeeva F. V. , Islamova D. R.
Published: December 2023

Currently, the contribution of genetic factors to the development of type 2 diabetes is becoming more obvious. Despite the available nine classes of hypoglycemic drugs, only 35–40 % of patients achieve an adequate glycemic control. One the reasons may be the genetic heterogeneity of diabetes mellitus. An increasing number of studies indicates that an individual set of gene polymorphisms can determine the therapeutic response to a particular drug and cause the development of undesirable effects. The article presents an overview of a new direction in the diagnosis and treatment of diabetes mellitus – personalized medicine. The pathogenetic mechanisms of the development of the disease, its heterogeneity and the difficulties of choosing the most effective hypoglycemic therapy are described. Data on the pharmacogenetic features of metformin are presented.
Editorial
Authors: Rivadulla López Juan Carlos
Published: December 2023

La revisión por pares es un elemento esencial de la publicación académica y uno de los más importantes pilares del proceso científico. Por ello, desde la Ápice. Revista de Educación Científica (AREC) queremos agradecer el esfuerzo y la experiencia que todos los evaluadores aportaron a las revisiones. A continuación, se incluyen los nombres y filiaciones de todos los revisores que han colaborado en el período 2017-2022 con Ápice. Revista de Educación Científica (AREC).
Análisis de las percepciones de los estudiantes del Grado en Educación Primaria sobre el uso del cine de animación de temática medioambiental
Authors: Fernández Díaz Manuel
Published: December 2023

La actual crisis ambiental tiene su origen en la actividad humana. Esta situación de graves alteraciones medioambientales requiere soluciones. La educación debe jugar un papel fundamental en el abordaje de estos problemas. En el marco de la formación inicial del profesorado de Educación Primaria, se plantea el presente trabajo para conocer cómo perciben los futuros maestros y maestras de Primaria los cortometrajes animados de temática medioambiental como posible recurso educativo. Se plantea una actividad de aula en la que, tras el visionado de varios cortos, los futuros docentes deben responder a una serie de preguntas de análisis. Las producciones escritas son sometidas a un análisis cualitativo de contenido. Entre las conclusiones más destacables pueden señalarse que los cortometrajes animados se perciben como un recurso útil para abordar contenidos medioambientales, sin embargo también se señala una formación inicial insuficiente para utilizar estos recursos adecuadamente.
Promoviendo la biodiversidad y el contacto con la naturaleza en los grados de educación
Authors: Torres Porras Jerónimo , Alcántara-Manzanares Jorge , Medina Quintana Silvia , Castro Francisca , Muñoz-García Isabel María , López Serrano Miguel Jesús , Guerrero Elecalde Rafael , Membrillo del Pozo Alberto , Sánchez-Vázquez Luis , Cortés Mármol Cristina de los Desamparados , Hidalgo Vaquerizas Patricia
Published: December 2023

En la sociedad actual existe una desconexión creciente con la naturaleza, lo que puede repercutir de forma negativa en el estado físico y mental, mostrando numerosos estudios los beneficios de estar en contacto con aquella. Es necesario, por lo tanto, la renaturalización de los centros educativos, incluidas las universidades. Las facultades de educación tienen, además, la oportunidad de servir de ejemplo para su numeroso estudiantado, de forma que puedan llevar las actuaciones y actividades realizadas durante el grado a los centros escolares. Este proyecto muestra la renaturalización de la Facultad de Ciencias de la Educación y Psicología de la Universidad de Córdoba (España), en la que se han reverdecido los espacios exteriores, se han adaptado para la docencia, se ha fomentado la biodiversidad y se ha facilitado la formación del estudiantado sobre la importancia de trabajar el contacto con la naturaleza como puntos clave para avanzar hacia la sostenibilidad.
El proyecto constitucional chileno como expresión del populismo constitucional
Authors: Peña Torres Marisol
Published: December 2023

El rechazo de la propuesta de nueva Constitución, en el plebiscito del 4 de septiembre de 2022, marca un hito en el devenir constitucional chileno y debe ser analizado cuidadosamente como respuesta de la ciudadanía al proceso desarrollado por la Convención Constitucional. Este artículo postula que dicho proceso fue una expresión del populismo constitucional, luego de examinar los elementos que lo configuran.
Penentuan Jumlah Sampel pada Penelitian Akuntansi dan Bisnis Berpendekatan Kuantitatif
Authors: Sofyani Hafiez
Published: December 2023

Latar Belakang: Isu penentuan jumlah sampel sering kali menjadi hal yang terabaikan di beberapa penelitian skripsi dan tesis. Tujuan: Paper ini mendiskusikan beberapa metode penentuan sampel yang dapat diadopsi oleh mahasiswa Sarjana dan Magister yang tengah menyelesaikan tugas akhir skripsi dan tesis mereka.Metode: Paper ini merangkum beberapa pendapat ahli terkait penentuan jumlah sampel minimal pada studi akuntansi dan bisnis yang umum digunakan.Hasil: Terdapat tiga metode yang belakangan sering digunakan dalam menentukan jumlah sampel minimal dengan argumentasi dan relevansi masing-masing, yakni: Pendekatan 10 kali rule of thumbs indikator variabel Laten untuk studi menggunakan Partial Least Square (PLS), Analisis Power, dan Tabel Krejcie dan Morgan.Keaslian/Kebaruan: Paper ini memberikan penyegaran kepada isu krusial pada riset kuantitatif yang kerap terabaikan, yakni penentuan jumlah sampel minimal.
Serological profile of IGG antibodies to viral capsid antigen of epstein-barr virus in oral pre-cancer and cancer patients
Authors: Jonathan Daniel M , Jimsha VK , Ganapathy KS , Mohan CV
Published: December 2023

Cancer of the oral cavity is a major and increasing public health problem. Oral cancer is the sixth most common cancer reported globally with an annual incidence of over 300,000 cases, of which 62% arise in developing countries. In India, because of cultural, ethnic, and geographic factors and the popularity of addictive habits, the frequency of oral cancer is high. Despite the various etiological and predisposing factors associated with oral pre-cancer and cancer, the role of co-carcinogenic effects of viruses like HSV has been documented. With this background and considering the high prevalence of oral cancer in India an attempt has been made to study the association of EBV with oral cancer using serological methods.

1. To study the IgG antibodies to Viral Capsid Antigen (VCA) of Epstein-Barr virus in oral pre-cancer and cancer by a laboratory standardized Indirect Immuno Fluorescent (IIF) test. 2. To compare and corelate the results of IIF test with a commercially available ELISA for VCA IgG antibodies to EBV. 3. To assess the severity of disease progression in oral pre-cancer and cancer using the serological profile.

In the present study, 84 subjects were assessed for serum IgG antibodies to VCA of EBV using the IIF technique and later the results were compared with an ELISA kit. Group I were controls, Group II to Group V were oral squamous cell carcinoma subjects according to the clinical staging. Group VI comprised of oral pre-cancer subjects. Age range was between 40-70 years, and the mean age was 50.31 +/- 8.23 years. All the 42 control sera were positive for IgG antibodies to VCA of EBV but with a significantly low geometric mean titre(GMT) of 8.561.The GMTs of oral squamous carcinoma and pre-cancer sera was positive but progressively increased when compared to control sera and were highly significant (P<0.001).

As there was a significant increase in the GMTs in oral squamous cell carcinoma subjects and pre-cancer subjects, serology of EBV may be interpreted to be useful in assessing the severity of the disease and the techniques of IIF and ELISA may be used as first line screeners when large number of subjects need to be assessed.
La supervivencia por sobre el ideal de maternidad: experiencias de duelo migratorio de las madres migrantes en Chile
Authors: Castillo Lobos Lucia , Contreras Vásquez Luis Patricio , Hermosilla Aldea Elizabeth Yenny
Published: December 2023

Este artículo da cuenta de una aproximación al fenómeno de duelo migratorio de las madres migrantes en Chile. Entre 2021 y 2022 se realizó un estudio cualitativo y exploratorio sustentado en el interaccionismo simbólico, en el que se realizaron entrevistas semiestructuradas a 39 madres migrantes: 18 de origen venezolano, 11 peruano y 9 haitiano. A partir del análisis de contenido temático y de la teorización, se obtuvieron tres categorías de análisis: 1) la pérdida de los vínculos y la lejanía con el origen, 2) expectativas versus realidad y 3) validando sobreesfuerzos. Las madres migrantes manifiestan el duelo migratorio con distintos matices según su país de origen e imprimen en cada una de sus experiencias, en mayor o menor grado, el desarraigo y la ausencia de redes de apoyo como principal detonante de la tristeza que viven día a día. Esta tristeza se acrecienta al negociar su ideal de criar personalmente a sus hijos e hijas en pro de la subsistencia material para alcanzar la ansiada vida mejor, para la cual validan el sobreesfuerzo como estrategia de superación. Estas presiones traen consigo consecuencias psíquicas y físicas que impiden la elaboración del duelo migratorio, comprometiendo su salud mental y la de sus hijos e hijas.
Improving the growth of Glycyrrhiza Glabra L. in saline soils using bioagent seed treatments
Authors: KHAİTOV Botir , TADJETDİNOV Nauruzbay , SAYİMBETOV Alisher , KHAİTBAEVA Jamila , SİNDAROV Obidjon , KHAKBERDİEV Obid , NEMATOV Tulkin
Published: December 2023

Licorice (Glycyrrhiza glabra L.), known for its salt and drought tolerance, presents a potential solution for addressing soil salinity and desertification challenges in arid areas. Since the natural habitat of this plant is dwindling sharply in the Aral Sea regions due to negative human interventions, so it is vital to create production technologies with biological means. This study determined the agronomic characteristics of licorice when bioagents i.e. Geohumate, Aminomax and Caliphos were used as a seed treatment. Results showed that the application of these biostimulators significantly improved seed germination and plant growth compared to the control. Especially the effect was more pronounced with Geohumate as the seed germination increased by 36.4%, whereas the impacts of Aminomax and Caliphos were 17.5% and 12.4% higher, respectively as compared to the control group. Likewise, under the open-field condition, plant growth and development were greater with the bioagent applications. In regards the root biomass, the highest record with a 29.1% increase was achieved after the Geogumat treatment, while Aminomax and Caliphos applications exhibited 24.4 and 23.9% higher values, respectively as compared to the control values. The amounts of ash, glycyrrhizic acid, extractive compounds and flavonoids were increased by 26.5%, 22.0, 9.4% and 10.4%, respectively, compared to the respective control values due to the positive effect of the Geogumat treatment. Furthermore, the improved organic and chemical contents of soil were explained by the bioremediation functions of licorice plus bioagents efficiency. Using bioagents in licorice production could be a valuable approach for maintaining ecosystem function and stability in saline lands.
Improving microbial properties in Psamments with mycorrhizal fungi, amendments, and fertilizer
Authors: HERAWATİ Aktavia , MUJİYO Mujiyo , DEWİ Widyatmani Sih , SYAMSİYAH Jauhari , ROMADHON Muhammad Rizky
Published: December 2023

Psamments is sandy soil with a texture class of fine loamy sand or coarser in all layers, deposited sands such as dunes in beach lands with low soil biological fertility. Adding mycorrhizal, soil amendments, and inorganic fertilizers could improve soil fertility. This research aimed to investigate the effect of mycorrhizal, soil amendments, and inorganic fertilizers on soil organic carbon (SOC), microbial biomass carbon (MBC), glomalin-related soil protein (GRSP), and root infections in Psamments. This research was a pot experimental in screenhouse, arranged in a factorial completely randomized design with three factors: three of mycorrhizal doses, M0 = 0 spore pot-1, M1 = 3 spores pot-1 and M2 = 6 spores pot-1; three types of soil amendments, P0 = non amendment, P1 = cow dung 60 t ha-1, P2 = rice husk biochar (RHB) 25 t ha-1; and two doses of inorganic fertilizer, A0 = 0 kg ha-1, A1 = 100 kg ha-1 NPK (15:15:15) fertilizer, replied three times. The results showed that mycorrhizal combination with RHB and inorganic fertilizer increased MBC up to 23 times than control. The combination of mycorrhizal-cow dung-inorganic fertilizer was the highest of total-GRSP (4.4 times) and mycorrhizal dose 6 spores pot-1 with both amendments and inorganic fertilizer increase root infection up to 90%. It was proven that mycorrhizal with soil amendments and inorganic fertilizers could improve the microbial properties of Psamments.
Enhancing phosphorus use efficiency in wheat grown on alkaline calcareous soils
Authors: ABBAS Muhammad , IRFAN Muhammad , SHAH Javaid Ahmed , SİAL Niaz Ali , DEPAR Nizamuddin
Published: December 2023

Phosphorus (P) use efficiency is crucial for sustainable wheat production, particularly on alkaline calcareous soils. This study investigates the relative importance of two factors; P acquisition efficiency (PAE) and P utilization efficiency (PUtE), in determining P use efficiency (PUE) in wheat. A field trial with ten wheat genotypes was conducted under two P levels (no P application and P application at 110 kg P2O5 ha−1). Results revealed significant genetic variability in PUE, PAE, and PUtE among wheat genotypes under varying P availabilities. Genotypes MK-4 and MK-8 exhibited superior PUE, making them ideal candidates for soils with differing P levels. PAE played a more substantial role in influencing PUE, with PUtE contributing less to the variability. The findings underscore the importance of improving PAE, particularly for wheat genotypes grown in P-deficient conditions. Moreover, selecting genotypes with lower grain P concentration can enhance PUtE, contributing to improved PUE. These insights can improve breeding efforts and crop management practices to enhance P use efficiency in wheat, ultimately reducing production costs and fertilizer demand, especially in P-limited alkaline calcareous soils.
The Relationships between Air Pollution, Warming, and Health in Tehran Metropolis, Iran, during 2015–2019
Authors: Daneshipour Kosar , Naghipour Armin , Rad Abdullah Kaviani
Published: December 2023

Introduction: Since global warming and air pollution was caused by human activities have increased dramatically in recent decades, studies have been conducted to determine how environmental parameters and air pollutants interact and, subsequently, how these pollutants affect ecosystems and human health. Accordingly, this study aimed to investigate the relationship between temperature and air pollutants in Tehran, Iran, in order to determine whether warming is associated with an increase in air pollutants.
Materials and Methods: During 2015-2019, Iran Air Quality Monitoring Station (AQMS) and the Landsat 8 satellite were employed to retrieve data on pollutants such as PM, CO, O3, NO2, SO2, and air quality index (AQI), as well as climate-related metrics including ambient temperature and land surface temperature (LST). Pearson correlation coefficient and linear regression model were used to analyze the data.
Results: A positive correlation was found between temperature variables and PM10 (ρ = 0.29, p = 0.001) and O3 (ρ= 0.55, p = 0.001) pollutants. PM10 and O3 levels were evaluated by 0.46 (95% Confidence Interval (CI) = (0.25, 0.67), p = 0.001) and 1.13 (95% CI = 0.89, 1.37), p = 0.001) units for each one-unit rise in temperature.
Conclusion: Given the fact that temperature predominantly evidenced a significant synergistic association with PM10 and O3, it was determined that there was no substantial positive association between all pollutants and warming.
Identification of Sarcocystis spp. in Hamburgers Distributed in Fouman City, North of Iran Using Dab Smear and Digestion Methods
Authors: Ahmadiara Emad , Rahimzadeh Amin , Samakkhah Shohreh Alian
Published: December 2023

Introduction: Human infection with Sarcocystis species can be attributed to the consumption of raw or inadequately cooked meat, such as hamburgers, containing encapsulated parasites.
 Materials and Methods: This cross-sectional study was conducted between April and September 2022 in Fouman, Iran. A total of 182 hamburger samples, comprising two types of traditional hamburgers and industrial hamburgers, were collected.
Result: Out of 182 hamburger samples of different types, 34% of them were found to be infected with Sarcocystis spp. The infection rate within industrial and traditional hamburgers was 21.5% and 56%, respectively. Notably, a statistically significant difference was observed between Sarcocystis-infested traditional and industrial hamburgers (p < 0.05). Among the two distinct groups of 182 hamburgers, the microscopic digestion method revealed the presence of Sarcocystis bradyzoites in all 51 infected traditional beef burgers and 19 positive industrial beef burgers. However, in the dab smear method, just 33 and 12 positive samples were respectively identified in traditional and industrial beef burgers and a statistically significant difference was observed between efficiency of these two methods (p < 0.05). Infection with macroscopic parasite cysts was not observed in any of hamburger samples. Similarly, no statistically significant association was identified between the meat content percentage and the infection rate in industrial hamburgers (p > 0.05).
 Conclusion: Considering the high abundance of Sarcocysts micro cysts in frozen raw hamburgers, it is recommended to fully cook this food product and avoid consumption when only partially cooked.
Public Acceptance of Water Reuse: Barriers and Facilitators in Yazd, Iran, in 2020
Authors: Rahaei Zohreh , Taghi Ghaneian Mohammad , Mohammadi Fatemeh Hasanzadeh , Ehrampoush Mohammad Hassan , Jambarsang Sara , Ghelmani Seyyed Vahid
Published: December 2023

Introduction: Droughts and precipitation imbalances in various parts of the world have underscored the significance of alternative water resources. In recent years, recycled water has emerged as a viable alternative, with wastewater being treated to a safe level for diverse purposes. However, the public acceptance of water reuse plays a pivotal role in determining the success of recycling initiatives. This study aims to identify the barriers and facilitators influencing public acceptance of water reuse in Yazd, Iran, during 2020.
Material and Methods: A descriptive cross-sectional study involving 384 individuals in Yazd city during 2020 was conducted. Participants were selected using the stratified sampling method. The data collection tool consisted of a researcher-made questionnaire, and the collected data were analyzed using descriptive statistics and the Pearson correlation test in SPSS software version 23.
Results: The most crucial facilitator for acceptance was the concept of segregating drinking water and recycled water networks. The primary barrier to acceptance was the perceived risk of recycled water contamination and potential health hazards. Water reuse was most widely accepted for construction purposes, followed by toilet flush tanks and irrigation of green spaces in parks and sports fields. A positive correlation (r = 0.416) existed between facilitators and acceptance of water reuse, indicating that enhancing facilitators positively affected acceptance.
Conclusion: To successfully implement water reuse projects, it is essential to consider key facilitators such as segregated water systems for different household uses, raising public awareness about the benefits of water reuse, and building public trust in recycled water safety.
Investigating the Residue of Diazinon, Chlorpyrifos, and Dichlorvos in Urban Drinking Water Supply Sources and Determining the Water Quality Index in Tirano-Korun in 2020
Authors: Ebrahimpour Karim , Ebrahimi Afshin , Baram Morad Mahmoudi
Published: December 2023

Introduction: Contamination of water sources with toxins is an environmental problem and a serious threat to the health of societies. This study aimed to ascertain the remaining levels of toxins in urban drinking water networks and compute the water quality index.
Materials and Methods: To examine the residual concentration of diazinon, chlorpyrifos, and dichlorvos in urban drinking water distribution networks, 35 underground and surface water sources were sampled in Tiran-o-Korun in Isfahan province, Iran. GC-ECD device was used to analyze the samples.
Results: Diazinon was not observed in any of the sampling seasons. The maximum concentration of chlorpyrifos and dichlorvos was 61 and 100 ppb, respectively. Although chlorpyrifos was seen more in the hot season and dichlorvos in the cold season, the mean concentration of these toxins in different seasons was lower than the guidelines of Iran and the World Health Organization (WHO). The mean concentration of nitrate, and hardness, in wet and dry seasons was 46.23 and 46.42, and 343.7 and 338.8 mg/l, respectively.
Conclusion: The mean and standard deviation of quality index of Iran's water resources (IRWQI) in wet and dry seasons were 52.16 ± 45.3 and 50.69 ± 15.8, respectively. The residual concentration of toxins in some water sources of this city exceeded the guidelines of Iran and the WHO in summer and spring.
Fuzzy Sub-Equality Algebras Based on Fuzzy Points
Authors: Kologani Mona Aaly , Takallo Mohammad Mohseni , Jun Young Bae , Borzooei Rajab Ali
Published: December 2023

In this paper, by using the notion of fuzzy points and equality algebras, the notions of fuzzy point equality algebra, equality-subalgebra, and ideal were established. Some characterizations of fuzzy subalgebras were provided by using such concepts. We defined the concepts of \((\in, \in)\) and \((\in, \in\! \vee \, {q})\)-fuzzy ideals of equality algebras, discussed some properties, and found some equivalent definitions of them. In addition, we investigated the relation between different kinds of \((\alpha,\beta)\)-fuzzy subalgebras and \((\alpha,\beta)\)-fuzzy ideals on equality algebras. Also, by using the notion of \((\in, \in)\)-fuzzy ideal, we defined two equivalence relations on equality algebras and we introduced an order on classes of \(X\), and we proved that the set of all classes of \(X\) by these order is a poset.
Etyczne aspekty pracy trenera personalnego
Authors: Kędzia Piotr
Published: December 2023

Profesja trenera personalnego to w ostatnich latach zawód charakteryzujący się dużą dynamiką rozwoju i posiadający cechy ekskluzywności, z uwagi na indywidualną formę pracy i koszt usługi. Ważnym elementem szerokiego wachlarzu kompetencji trenera jest umiejętność etycznego postępowania w pracy z klientem. Jest ona niezwykle istotna gdyż zawód trenera osobistego polega w głównej mierze na bezpośrednim kontakcie z klientami. Wysoki standard etyczny trenera wzmacnia jego autorytet, buduje wiarygodność, zwiększa zaufanie, by w konsekwencji przełożyć się na prestiż własnej marki. W toku doskonalenia sprawności etycznej trenerów warte uwagi wydają się być również kodeksy etyczne. Ich założenia zostały zaprezentowane w drugiej części tekstu. Celem artykułu jest ukazanie etycznych aspektów zachowań trenerów personalnych i ich konfrontacja z przyjętymi standardami.
Letter to Editor: “Prevalence of Substance Abusers in a Tourist Area”
Authors: Fabbri Nicolò 
Published: December 2023

The article entitled “Prevalence of Substance Abusers in a Tourist Area” covers one important topic that involves a huge amount of people worldwide, which is drug abuse. In particular, the authors searched for the prevalence of substance and polysubstance abusers among tourists in an Indian region. Interesting data are coming from dozens of studies concerning drug abuse, every year, but little is know about the relationships existing between this insane behavior and the clinical history of the patients involved, or how comorbidities modify their prognosis. According to this, the approach of clinicians is inevitably different by case, it is strongly conditioned by the clinical state of subjects and needs to be personalized after evaluation of potential interfering drugs and coexisting systemic diseases.
Elucidate the Influence of Heavy Metal on Bacterial Growth Isolated from a Mining Location and A Waste Dump: Using their Inducible Mechanism
Authors: Meenu S Saraf
Published: December 2023

The main aim of this study was to analyze the mobilization of storage reserves during seed germination of Citrus limon by host plant-endophytic bacteria interaction and to determine the contribution of endophytic bacteria in plant establishment. The seeds were inoculated with three different endophytic bacteria from Bacillus spp. which were isolated from the leaf of Citrus limon plant, and they were germinated in the dark. Fresh weight changes and early seedling growth were assessed, in all germinated and non-germinated seeds. To understand the mechanism promoting seed germination, the activities of extracellular enzymes of bacterial isolates were also analyzed by the plate assay method. The results showed that treatment with endophytic bacteria accelerated during the germination process. In summary, our current study showed that endophytic bacteria improved seed germination and post-germination seedling growth of Citrus limon plant inoculation with endophytic bacteria could promote storage reserve mobilization during or following germination; three bacterial isolates might have different action mechanisms on seed germination. The improved germination percentage and decreased germination period (GPD) using external agents can be exploited in conservation of this overexploited medicinally important plant.
Review of Wear Model Optimization for Ceramic and Metal Total Hip Arthroplasty with Medical Physics Applications
Authors: Casesnoves Francisco
Published: December 2023

In a series of previous contributions, two types of bioengineering studies of total hip arthroplasty (THA) modelling optimization were presented. Namely, computational modelling THA in vitro wear modelling parameter optimization for ceramic-on-ceramic (CoC), and metal-on-metal THA (MoM) one. The objective of the research was to obtain the optimal-principal model parameters for in vitro tribological predictions. These optimal are an adimesional K constant parameter, hardness, and hip-biomechanical load over the THA implant. In those contributions, the aim was carry out both dual and multi objective optimization. In ceramic, dual optimization was presented for Alumina (Al3O2), and Zirconium (ZrO2) CoC, and secondly a multi objective one for Alumina, Zirconium, ZTA Biolox, and ZTA Biolox-Delta. In metal, dual optimization was obtained for Titanium and Co-Cr-Mo materials. This article presents a review of those most important results in Numerical, 2D Graphical, and 3D Interior Optimization. Applications obtained are useful/efficacious for in vitro tribology predictions in the area of clinical medical physics and bioengineering—with the new 4D Interior Optimization included. A second innovation related to the reviewed papers group is the GNU-Octave software design/comparison with Matlab for 4D Interior Optimization graphics. Most important of these usages in ceramic and metal are an adimensional K for wear modelling, and a optimal model parameter group for THA erosion/durability tribopredictions. Clinical orthopedics, bioengineering, and medical physics applications emerge from all the results.
Suppression of Estrogen Receptor in Breast Cancer Cells via Transferrin Coated Gold Nanoparticles Carrying Antisens Oligonucleotides
Authors: Kevser Piskin Ayse 
Published: December 2023

Breast cancer is the most common cancer of women. In breast cancer treatment the estrogen receptor is an established target in receptor positive tumors. A novel approach to therapy is gene regulation by oligonucleotide drugs. Antisens oligonucleotide therapy is facing with some difficulties such as targeting a polianionic nucleotide into the tumor cell. In order to form an efficient carrier system to protect and target antisens oligonucleotides against estrogen receptor α mRNA, a gold nanoparticle based construct is formed. Uptake of amino and thiol modified gold nanoparticles was analysed by confocal microscopy. Gold nanaparticles were functionalysed by transferrin coating and estrogen receptor α antisens oligonucleotide and were applied to MCF7 breast cancer cells. It was found that funtionalized gold nanoparticles decreased the estrogen receptor expression by 51% as well as cell proliferation upto 41.00 ± 5.6 % of untreated cells. Therefore, this targeting construct using the transferrin receptor and receptor mediated endocytosis process delivers the antisens oligonucleotide efficiently. Since estrogen receptor α is an important regulator of cell proliferation, this system is able to inhibit proliferation by means of decreasing the expression level of this major regulatory molecule. It is concluded that, this functionalysed gold nanoparticle system may be designed for other targets in tumors and may also be used as a teranostic agent.
Identification and Estimation of Total Tannins from Citrus limon l. Burm. F. (lemon) and its endophytes
Authors: Meenu S Saraf
Published: December 2023

Citrus limon (Lemon) is a member of the Rutaceae family and it is also known as Kagdi Limbu or Lime. The purpose of the study was to determine the total tannin content of Citrus limon plant and endophytes isolated from the leaves, steam, root, seed, and peel. By using Bromocresol green approach and HPLC with Gallic acid and tannic acid as standards, the total tannin content (TTC) was determined spectrophotometrically. Tannins present in excess amount. Leaf extricates had the highest tannin content of the various sections studied. TLC, spectrophotometric, FTIR, HPLC, and GCMS tests were used to determine the total tannins content of different Endophytes isolated from whole Citrus limon plant vs extract of Citrus limon plant. Intriguingly, a close examination of all out tannins in Endophytes was completed, which can be used.
Recent Progress in Biosensors for Diagnosis of Cancer Cells, Tissues and Tumors Biomarkers
Authors: Heidari Alireza
Published: December 2023

Raman spectroscopy is an important method for identifying molecules, which is widely used in determining the chemical and structural characteristics of various substances. Many materials have a special Raman spectrum, so that this phenomenon has turned the Raman device into an efficient tool for studying the structural and chemical properties of molecules. Since it is possible to obtain detailed information about the chemical and structural characteristics of biological compounds from Raman spectroscopy, the use of this method is rapidly expanding in the field of life sciences, especially in biological and medical studies. There is no need for special, time-consuming and expensive preparations in the study of materials with the help of a Raman device. In the protein Raman spectrum, distinct bands arise from the vibrational states of the peptide backbone and amino acid side chains. Therefore, based on the position and intensity of the protein’s Raman spectrum, it is possible to obtain valuable information about its second, third, and fourth structures. Also, the Raman spectrum of the protein contains information about the orientation and surrounding environment of the amino acid side chains. The correct formation of the disulfide bond in the protein structure can also be studied with the help of the Raman device. In general, the Raman spectrum of proteins contains multiple discrete bands that represent the vibrational states of the molecule and is used as a selective fingerprint to accurately determine the three–dimensional structure of proteins, intramolecular dynamics, and intermolecular interactions (Graphical Abstract).
Laporan Kasus: Penanganan Demodekosis General pada Anjing Kacang Betina di Bali
Authors: Teja Putu Tessa Hariys Septianda , Jayanti Putu Devi , Anthara Made Suma
Published: December 2023

Seekor anjing kacang berumur 11 bulan, berjenis kelamin betina dengan gejala klinis pruritus dan tanda klinis alopesia dan krusta pada tepi mata, mulut, telinga, kaki depan, kaki belakang, dan abdomen serta eritema pada bagian abdomen, kaki depan, dan kaki belakang serta eritema pada bagian abdomen, kaki depan, dan kaki belakang. Pada pemeriksaan kerokan kulit hingga berdarah atau deep skin scraping dan tape smear, ditemukan tungau Demodex sp. Hasil pemeriksaan hematologi rutin menunjukkan anjing kasus mengalami anemia mikrositik hipokromik dan limfositosis. Berdasarkan anamnesis, pemeriksaan fisik, dan pemeriksaan penunjang, anjing kasus didiagnosis menderita demodekosis general. Pengobatan dilakukan dengan pemberian antiparasit yang megandung ivermectin dengan dosis 0,3 mg/kg BB subkutan, antihistamin yang mengandung diphenhydramine HCl dengan dosis 0,1 mg/kg BB intramuskuler dengan interval pengulangan sekali dalam seminggu selama dua minggu, dan dilanjutkan dengan pemberian antihistamin yang mengandung chlorpheniramine meleate dengan dosis 3 mg/kg BB secara peroral sekali sehari selama 10 hari dan fish oil dengan dosis 500 mg/hari peroral sekali sehari selama 30 hari, serta anjing dimandikan dengan sabun yang mengandung sulfur sekali dalam seminggu. Setelah 14 hari pengobatan, anjing kasus menunjukan perubahan kondisi berupa berkurangnya derajat pruritus, eritema dan krusta yang perlahan menghilang serta rambut yang mulai tumbuh.
Resepsi atas Islam Moderat: Antara Kritik dan Sikap yang Representatif
Authors: Benny Afwadzi
Published: December 2023

Until now, many rejections of the terminology of Islam Nusantara have emerged, not only among the general public, but also in the academic environment. In fact, moderate Islam is a means to tackle extremism, radicalism, and terrorism. Therefore, a systematic description of what is meant by moderate Islam is needed from various literatures. It is for this purpose that this article was written. With a qualitative approach and the type of literature research on works related to moderate Islam, it was found that moderate Islam must be understood with middle Islam, not extreme right or left. Although in Western literature, moderate is synonymous with liberal and secular, but a representative attitude is to filter what comes from the West. Not everything that comes from the West must be accepted, and not all must be rejected, as well as the terminology of moderate Islam. Even the arguments against moderate Islam, if analyzed, have a fundamental weakness, because they are not in accordance with the spirit of moderate Islam. The basis for the foundation of moderate Islam is clear, namely Q.S. al-Baqarah [2]: 143, so it has a normative basis that can be accounted for. Furthermore, Islam in the archipelago is essentially a representation of moderate Islam, although it must be admitted that not all adherents are moderate.

 (Sampai saat ini, penolakan terhadap terminologi Islam Nusantara banyak bermunculan, tidak hanya di kalangan masyarakat awam, namun juga di lingkungan akademik. Padahal, Islam moderat adalah sarana untuk menanggulangi ekstremisme, radikalisme, dan terorisme. Oleh sebab itu, diperlukan uraian yang sistematis terkait apa yang dimaksud dengan Islam moderat dari berbagai literatur. Untuk tujuan itulah artikel ini ditulis. Dengan pendekatan kualitatif dan jenis penelitian pustaka terhadap karya-karya terkait Islam moderat, ditemukan bahwa Islam moderat haruslah dipahami dengan Islam pertengahan, tidak ekstrem kanan maupun kiri. Meskipun dalam literatur Barat, moderat identik dengan liberal dan sekuler, akan tetapi sikap yang repreentatif adalah dengan melakukan filterisasi terhadap apa yang datang dari Barat. Tidak semua yang datang dari Barat harus terima, dan tidak pula semua pula harus ditolak, begitu pula terminologi Islam moderat. Argumen-argumen penolak Islam moderat pun, jika dianalisis, mempunyai kelemahan yang mendasar, karena tidak sesuai dengan semangat Islam moderat. Dasar pijakan Islam moderat pun jelas, yakni Q.S. al-Baqarah [2]: 143, sehingga  mempunyai landasan normatif yang bisa dipertanggungjawabkan. Lebih lanjut, Islam yang ada di Nusantara ini pada hakikatnmya merupakan representasi Islam moderat, meski harus diakui bahwa tidak semua penganutnya berpaham moderat.)
Portrait of Islamic Religious Education in Public Universities in the 5.0 Era
Authors: Bachrul Ulum  , Mohammad Hasib  , Moh. Zaini
Published: December 2023

In the 5.0 era, Islamic religious instruction in higher education is crucial as in forming students' morality and character. With a correct and deep understanding of religion, students can internalize these values in their daily lives and make good and responsible decisions. The article's aim is to give an outline of the Islamic religious teaching and learning processes in public colleges as of 5.0. A qualitative research methodology was adopted, and instructors and students were interviewed as well as observed to obtain data involved in the learning and teaching process of Islam in public universities. Then, content analysis is used to assess the acquired data utilizing qualitative data analysis techniques. The findings indicated that there is still room for improvement in the standard of Islamic religious instruction in public universities, especially in terms of subpar teaching and learning. Lack of emphasis on character education, poor teaching, and minimal use of technological in the process of learning and instruction are some of the reasons that contribute to the poor quality of Islamic religious education in public universities. Thus, character education, raising the bar of instruction, and implementing better technology in the learning and teaching process of Islam in the 5.0 era are necessary to improve the quality of Islamic religious instruction in public universities. 

(Di era 5.0, pengajaran agama Islam di perguruan tinggi menjadi sangat penting dalam membentuk moralitas dan karakter mahasiswa. Dengan pemahaman agama yang benar dan mendalam, mahasiswa dapat menginternalisasi nilai-nilai tersebut dalam kehidupan sehari-hari dan mengambil keputusan yang baik dan bertanggung jawab. Artikel ini bertujuan untuk memberikan gambaran umum tentang proses pengajaran dan pembelajaran agama Islam di perguruan tinggi umum di era 5.0. Metodologi penelitian kualitatif diadopsi, dan para pengajar serta mahasiswa diwawancarai serta diobservasi untuk mendapatkan data yang terlibat dalam proses belajar dan mengajar agama Islam di perguruan tinggi umum. Kemudian, analisis isi digunakan untuk menilai data yang diperoleh dengan menggunakan teknik analisis data kualitatif. Temuan penelitian menunjukkan bahwa masih ada ruang untuk perbaikan dalam standar pengajaran agama Islam di perguruan tinggi umum, terutama dalam hal pengajaran dan pembelajaran yang masih di bawah standar. Kurangnya penekanan pada pendidikan karakter, pengajaran yang buruk, dan minimnya penggunaan teknologi dalam proses belajar mengajar merupakan beberapa alasan yang berkontribusi terhadap rendahnya kualitas pendidikan agama Islam di universitas umum. Oleh karena itu, pendidikan karakter, peningkatan standar pengajaran, dan penerapan teknologi yang lebih baik dalam proses pembelajaran dan pengajaran agama Islam di era 5.0 sangat diperlukan untuk meningkatkan kualitas pengajaran agama Islam di perguruan tinggi umum.)
SELFADJUSTMENTOF TRANS GENDERAT THE AL-FATAH WARIA ISLAMIC BOARDING SCHOOL
Authors: Rohman Ahmad Aulia
Published: December 2023

This research aims to explore the experiences of transgender individuals in their self-adjustment within Islamic boarding schools, commonly known as pesantrens. It examines the challenges faced by transgender individuals, the strategies employed by pesantrens to facilitate their self-adjustment, and the role of culture and religion in shaping their experiences. The study also investigates the significance of social support networks in assisting transgender individuals during their journey of self-adjustment within pesantrens. Through qualitative interviews with transgender individuals and founders of pesantrens, this research sheds light on the intersection of gender identity and religious beliefs. The findings highlight the importance of understanding, acceptance, and support in promoting the well-being and successful adjustment of transgender individuals in pesantrens. This research contributes to the discourse on inclusivity and empowerment within religious educational institutions
Molar pregnancy frequency of abortions in our clinic and pre-diagnosis success
Authors: ŞEHİRLİ KINCI Özge , KINCI Mehmet Ferdi , ARSLANER Mehmet Onur , MİRZAZADA Firangiz , ÜNÇEL Melek
Published: December 2023

Aim: Abortion is the termination of pregnancy before the 20th gestational week or when the fetus is below 500 g. Its prevalence is between 50-70% in all pregnancies. Routine histological examination (HE) of abortion materials is controversial in terms of molar pregnancy (MP) diagnosis. This study aims to determine the necessity of HE by evaluating the MP frequency and pre-diagnosis success of abortions in our clinic.

Materials and Methods: In this retrospective study, 1007 women whose pregnancy resulted in abortion between 01.01.2019-01.01.2022 and whose demographic data, USG findings, pre-diagnoses and HE results were present, were included. The preliminary diagnoses of patients with CMH and PMH were compared with the HE results.

Results: Among the materials sent to pathology for HE, the most common diagnosis was missed abortion with 590 (58.78%). MP was detected in 32 (3.17%) women. Of these, 9 (0.89%) were found to be CMH, while 23 (2.28%) were PMH. While 6 (66.6%) of 9 patients diagnosed with CMD were prediagnosed with CMD, 10 (43.37%) out of 23 patients diagnosed with PMH were prediagnosed as PMH.

Conclusion: Since the prevalence of MP is 3.17% and there is a high inconsistency between the pre-diagnosis and the result of HE, we recommend that all abortion materials be performed with HE.
Covıd-19 Pandemisinin Türkiye’deki Anestezi Asistanlarının Eğitim Durumuna Etkisi-Anket Çalışması
Authors: YUKSEL Aslıhan , SAHUTOGLU Cengiz , ZİNCİRCİOĞLU Çiler , ÖZBİLGİN Şule , UYAR Meltem
Published: December 2023

Amaç: COVID-19 salgını eğitim sistemlerinin bugüne kadar yüzleştiği en büyük sorunlardan birisi olmuştur. Bu çalışmanın amacı COVID-19 pandemi döneminde Türkiye’de Anesteziyoloji ve Reanimasyon asistanlarının eğitim eksikliklerini belirlemektir.

Gereç ve Yöntem: Çalışmamız Sağlık Bakanlığı ve Ege Üniversitesi Tıp Fakultesi Hastanesi Etik Kurul onayı alındıktan sonra yapılmıştır. Bu çalışma kesitsel bir anket çalışmasıdır. Türkiye’deki Eğitim ve Araştırma Hastaneleri ve Üniversite Hastanelerinde, Anesteziyoloji ve Reanimasyon Uzmanlık Öğrencilerine 32 soru içeren web bazlı anket bilgisayar ortamında TARD onayı ile e-mail ile gönderilerek gerçekleştirilmiştir.

Bulgular: COVID-19 pandemi döneminde eğitim saatleri hem Üniversite Hastanelerinde hem de Sağlık Bakanlığı Eğitim ve Araştırma Hastanelerinde anlamlı olarak azalmıştı (p
History Of The Stromal Cells: From Interstitial Cajal Cells To Telocytes - A Brief Overview Of The Human Telocytes And Their Possible Functions
Authors: PURELKU Merjem , TANRIVERDİ Gamze
Published: December 2023

In the organ microenvironment stromal cells make up an essential population, however research on them has been very limited. The stroma mainly consists of fibroblasts that reside together with mesenchymal cells, endothelial cells, pericytes, neurons, adipocytes, immune cells etc. The different morphologies and functional properties of stromal cells have led to subclassification of different cell types in connective tissue. Among them are the interstitial cells of Cajal and telocytes. Telocytes are one of the newer cells known for their small cell bodies and long telopods and have been recently identified in the connective tissue of many organs. Telocytes are strategically positioned near nerve endings, around blood capillaries and in close relation with particular cells. The network of telocytes is engaged in integrating information from multiple sources and coordinating the tissue homeostasis in response to the tissues local functional requirements. Extracellular vesicles provide a means of bidirectional communication, and their secretome appears to control the mechanisms of stem cell differentiation. Telocytes have been identified in various organs, specifically in human heart, lungs, brain, eye, thyroid, skeletal muscles, skin, salivary glands, gastrointestinal tract, pancreas, gallbladder, liver, and organs of the male and female urogenital system. Additionally, given the heterogeneity of the organs in which telocytes are found, and their capability to play a role in the etiopathogenesis of various diseases, the concept of "telocytopathies" has emerged. In conclusion, telocytes are increasingly becoming a focal point for the understanding of idiopathic diseases that affect humans as well as the development of new diagnostic and therapeutic approaches, and they have the potential to contribute to regenerative medicine.