bluuebunny/crossref_metadata_2025 huggingface dataset:
Analisis Dinamik Model Predator-Prey Dengan Fungsi Respon Monod Haldane
Authors: Amalia Difitri , Savitri Dian
Published: September 2023

Setiap makhluk hidup tidak terlepas untuk berinteraksi dengan makhluk hidup lainnya.Interaksi terjadi ketika dua atau lebih spesies memiliki efek atau mempunyai pengaruh terhadap masing-masing spesies tersebut. Penelitian ini membahas model prey predator mengikuti lotkal voltera dengan fungsi respon Monod-Haldane.Tahapan penelitian ini diawali dengan studi literatur, kemudian merekonstruksi model predator prey, dilanjutkan analisis dengan menentukan titik kesetimbangan, dan kestabilan lokal di sekitar titik kesetimbangan. Hasil analisis diperoleh tiga titik kesetimbangan yaitu E1 kepunahan populasi prey dan predator,  E2 kepunahan populasi predator dan E3 hidup berdampingan. Hasil analisis kestabilan pada titik E1 stabil, E2 stabil dengan syarat  artinya predator tidak mampu menangkap mangsa dengan laju yang cukup untuk kelangsungan hidup populasi predator dan tidak stabil  artinya predator memiliki kemampuan untuk menangkap mangsa dengan laju yang cukup tinggi, yang dapat mendukung pertumbuhan atau kelangsungan hidup populasi predator. dan E3 tidak stabil. Hasil simulasi numerik diperoleh adanya terdapat dua titik kesetimbangan yang stabil yaitu E2 titik kepunahan predator dan E3 titik populasi hidup secara bersamaan, fenomena ini disebut bistabil atau kestabilan ganda saat parameter laju penangkapan predator β = 0.7. Saat β menurun solusi yang stabil hanya terjadi di titik kepunahan pada predator E2.

Kata kunci: Model Predator-Prey, Fungsi Respon, Monod Haldane, Bistabil
Stabilitas Model Matematika Penularan Penyakit Mulut dan Kuku (PMK)
Authors: Sari Aulia Nurita , Maulana Dimas Avian
Published: September 2023

Penyakit Mulut dan Kuku (PMK) adalah penyakit yang disebabkan oleh Foot-and-Mouth Disease Virus (FMDV) dari genus Apthovirus dan keluarga Picornaviridea yang menyerang semua hewan berkuku genap atau belah seperti sapi, kerbau, babi, kambing, domba dan termasuk satwa liar. Penyakit ini bukan termasuk zoonosis (penyakit yang dapat menular pada manusia). Penelitian ini bertujuan untuk memodelkan PMK secara matematis, mengetahui kestabilan, dan melakukan simulasi numerik model penyebaran PMK. Pada penelitian ini, populasi dibagi menjadi empat kompartemen yaitu rentan/suspectible (S), laten/latent (L), terinfeksi/infected (I) dan sembuh/recovered (R). Dari model SLIR ditentukan titik kesetimbangan bebas penyakit dan titik kesetimbangan endemik, kemudian dianalisis kestabilannya dengan menggunakan kriteria Routh-Hurwitz. Selanjutnya ditentukan bilangan reproduksi dasar (R0) dan dilakukan analisis sensitivitas terhadap  . Berdasarkan hasil analisis kestabilan pada model SLIR, titik kesetimbangan bebas penyakit stabil jika R0 < 1 yang artinya PMK akan menghilang dan titik kesetimbangan endemik stabil jika R0 > 1 yang artinya PMK akan tetap ada dan menjadi endemik. Hasil simulasi numerik dapat diketahui bahwa terjadi endemik PMK di Provinsi Jawa Timur, hal ini diperkuat dengan nilai  R0 = 1,16 yang berarti R0 > 1. Berdasarkan analisis sensitivitas terhadap  tingkat masa inkubasi  merupakan parameter yang sensitif. Berdasarkan hasil simulasi numerik dengan mengubah nilai parameter tingkat masa inkubasi dapat diketahui bahwa PMK akan menghilang seiring berjalannya waktu apabila  hal ini diperkuat dengan R0 = 0,33.
Model Lotka-Volterra yang Mempertimbangkan Efek Ketakutan pada Prey dengan Fungsi Respon Holling Tipe II
Authors: Rahmawati Ruli , Savitri Dian
Published: September 2023

Interaksi antar populasi pada ekosistem sawah antara burung hantu (Tyto alba) dengan tikus sawah (Rattus argentiventer) direpresentasikan sebagai model predator-prey yang mempertimbangkan efek ketakutan. Interaksi dua populasi ini menggunakan fungsi respon Holling tipe II. Model predator-prey ini dikonstruksi berdasarkan asumsi perilaku prey yaitu tikus sawah yang memiliki efek ketakutan terhadap predator burung hantu. Berdasarkan beberapa jurnal rujukan yang dikembangkan dengan pola pemangsaan menggunakan fungsi respon Holling tipe II. Analisis perhitungan pada penelitian ini dilakukan dengan mencari titik kesetimbangan dan analisis kestabilan. Hasil analisis didapatkan titik kesetimbangan , ,  dan  dengan A =  > 0, B = , C = . Hasil analisis kestabilan didapatkan titik E0 = (0,0) tidak stabil, E1 = ( ,0) stabil dengan syarat  artinya kepunahan populasi predator terjadi saat konversi biomassa prey ke predator lebih besar dari kompetisi intra spesies prey, titik  dan  stabil dengan syarat g > µ artinya populasi prey dan predator tetap ada saat konversi biomassa prey ke predator lebih dari kematian alami predator. Simulasi numerik dilakukan untuk mengetahui kesesuaian hasil analisis dengan menggunakan aplikasi Phyton. Hasil simulasi numerik terhadap solusi sistem didapatkan konversi biomassa prey ke predator dengan berpengaruh pada kestabilan kedua populasi.

Kata Kunci: Lotka-Volterra, efek ketakutan, Holling II.
Synthesizing Familial Linkages for Privacy in Microdata
Authors: Benedetto Gary , Totty Evan
Published: September 2023

As the Census Bureau strives to modernize its disclosure avoidance efforts in all of its outputs, synthetic data has become a successful way to provide external researchers a chance to conduct a wide variety of analyses on microdata while still satisfying the legal objective of protecting privacy of survey respondents. Some of the most useful variables for researchers are some of the trickiest to model: relationships between records. These can be family relationships, household relationships, or employer-employee relationships to name a few. This paper describes a method to match synthetic records together in a way that mimics the covariation between related records in the underlying, protected data.
Optimizing Error of High-Dimensional Statistical Queries Under Differential Privacy
Authors: McKenna Ryan , Miklau Gerome , Hay Michael , Machanavajjhala Ashwin
Published: September 2023

In this work we describe the High-Dimensional Matrix Mechanism (HDMM),a differentially private algorithm for answering a workload of predicate counting queries.  HDMM represents query workloads using a compact implicit matrix representation and exploits this representation to efficiently optimize over (a subset of) the space of differentially private algorithms for one that is unbiased and answers the input query workload with low expected error. HDMM can be deployed for both ϵ-differential privacy (with Laplace noise) and (ϵ, δ)-differential privacy (with Gaussian noise), although the core techniques are slightly different for each. We demonstrate empirically that HDMM can efficiently answer queries with lower expected error than state-of-the-art techniques, and in some cases, it nearly matches existing lower bounds for the particular class of mechanisms we consider.
Private Boosted Decision Trees via Smooth Re-Weighting
Authors: Jahanara Mohammadmahdi , Asadi Vahid , Carmosino Marco , Rafiey Akbar , Salamatian Bahar
Published: September 2023

Protecting the privacy of people whose data is used by machine learning algorithms is important. Differential Privacy is the appropriate mathematical framework for formal guarantees of privacy, and boosted decision trees are a popular machine learning technique. So we propose and test a practical algorithm for boosting decision trees that guarantees differential privacy. Privacy is enforced because our booster never puts too much weight on any one example; this ensures that each individual's data never influences a single tree "too much." Experiments show that this boosting algorithm can produce better model sparsity and accuracy than other differentially private ensemble classifiers.
"I need a better description": An Investigation Into User Expectations For Differential Privacy
Authors: Cummings Rachel , Kaptchuk Gabriel , Redmiles Elissa
Published: September 2023

Despite recent widespread deployment of differential privacy, relatively little is known about what users think of differential privacy. In this work, we seek to explore users' privacy expectations related to differential privacy. Specifically, we investigate (1) whether users care about the protections afforded by differential privacy, and (2) whether they are therefore more willing to share their data with differentially private systems. Further, we attempt to understand (3) users' privacy expectations of the differentially private systems they may encounter in practice and (4) their willingness to share data in such systems. To answer these questions, we use a series of rigorously conducted surveys (n=2424).
 
We find that users care about the kinds of information leaks against which differential privacy protects and are more willing to share their private information when the risks of these leaks are less likely to happen.  Additionally, we find that the ways in which differential privacy is described in-the-wild haphazardly set users' privacy expectations, which can be misleading depending on the deployment. We synthesize our results into a framework for understanding a user's willingness to share information with differentially private systems, which takes into account the interaction between the user's prior privacy concerns and how differential privacy is described.
Non-Invasive Approaches in Interventional Cardiology for Addressing Cardiovascular Disease Burden in Low-Income Countries.
Authors: Ahmed Sadaf , Noushad Shamoon
Published: September 2023

Interventional cardiology has traditionally been associated with invasive procedures such as angioplasty and stenting. However, there is a growing recognition of the importance of non-invasive strategies in the field of interventional cardiology. This scientific article explores the role of non-invasive interventions, including lifestyle modifications, patient education, and comprehensive management approaches, in preventing and managing cardiovascular disease. By empowering patients and focusing on holistic care, these non-invasive strategies have the potential to significantly improve patient outcomes and reduce the burden of cardiovascular disease. This article highlights the various non-invasive interventions, their mechanisms of action, and their impact on patient well-being and long-term cardiovascular health. Additionally, it discusses the challenges and opportunities associated with implementing these strategies in clinical practice, emphasizing the importance of a multidisciplinary approach and patient-centered care. Through a comprehensive understanding of non-invasive strategies, interventional cardiologists can optimize patient care and contribute to the prevention and management of cardiovascular disease.
To assess the impact of prior urethral dilatation or DVIU on the outcome of anterior urethroplasty.
Authors: Tanzeel ur Rahman Gazder  , Kanwal Naz  , Vikram Seetlani  , Syed Rabiullah  , Usman Qamar  , Mazahir Zulfiqar  , Hamza Akhter  , Saeed Abdi  , Manzoor Hussain
Published: September 2023

Background: Male urethral stricture has remained the major problem in urologic practice. Patients presenting with urethral stricture disease are commonly managed by dilatation, DVIU, and urethroplasty.

Methodology: This is a descriptive study of male patients who underwent anterior urethroplasty at our setup from 5th August 2021 to 25th February 2022. We analyzed the age, duration, type, length, and location of the stricture and the surgical treatment outcome after urethroplasty. The post-operative catheter was removed after 3 weeks, and UFM is advised. Qmax (max flow rate) > 15 ml/sec was measured on UFM (uroflowmetry) on the 1st week, 6 weeks, and followed on 3 months. Final outcome in terms of success was assessed by uroflowmetry. A maximum urine flow greater than 15mL/s after 3 months’ treatment assessed by uroflowmetry was considered as success.

Results: In our study, the blood loss in group A and group B patients, those patients who had DVIU or dilation in the past, had more bleeding during surgery than those who did not have a history of surgery. 66.67% of group B patients have bleeding from 200 ml to 500 ml, which is higher than group A patients. In our study, we found that if the patient had undergone surgery or no surgery had taken place before urethroplasty, the results in terms of UFM were quite similar, as in group A, 96.69% of patients had UFM more than 15 ml/sec, and in group B 87.88% had UFM more than 15 ml/sec.

Conclusion: Urethral dilatation or DVIU delays definitive treatment and increases operative challenges by increasing the length of stricture, more adhesion, and more fibrosis but has minimal impact on the outcome of urethroplasty success.
Determing the success rate of extracorporeal shock wave lithotripsy in renal pelvis stone of 1-2 cm in size.
Authors: Nisar Ahmed  , Tanzeel Gazder  , Hafiz Saad  , Khan Ajmal , Syed Rabiullah  , Mazahir Zulfiqar  , Usman Qamar  , Munawar Khaliq  , Saeed Abidi  , Manzoor Hussain
Published: September 2023

Background: Despite its historical significance, ESWL has witnessed changes in its role, necessitating refined technical approaches and stringent patient selection criteria for optimal outcomes. This study aims to assess the efficacy of extracorporeal shock wave lithotripsy (ESWL) for treating renal pelvis stones ranging from one to two centimeters in size.Methodology: A descriptive case series was conducted at the Department of Urology and Renal Transplantation, SIUT, Karachi. The study enrolled 81 patients aged 20 to 60, of both genders, with a single renal pelvis stone sized 1 2 cm. Patients with ureteral obstruction were excluded. Informed consent was obtained before performing extracorporeal shock wave lithotripsy (ESWL). Follow ups were carried out regularly, and final success was assessed one month post ESWL session.Results: The mean age of participants was 41.93 ± 9.67 years, with the majority (54.32%) falling within the 41 to 60 age range. Out of 81 patients, 49 (60.49%) were male and 32 (39.51%) were female, resulting in a male-to-female ratio of 1.5:1. The mean stone size was 14.22 ± 2.01 mm. In the study, the success rate of ESWL for renal pelvis stones sized 1-2 cm was 85.19%, with 69 patients showing successful outcomes.Conclusion: In conclusion, the success rate of ESWL for treating renal pelvis stones sized 1-2 cm is notably high. This finding underscores the effectiveness of this non-invasive procedure in managing such cases.
Frequency of complications of transurethral pneumatic lithotripsy in pediatric bladder stone disease.
Authors: Farman Ullah  , Tanzeel Gazder  , Sanjeet Therani  , Izhar Ali  , Hamza Akhtar  , Usman Qamar  , Syed Rabiullah  , Mazahir Zulfiqar
Published: September 2023

Background: Despite advancements, underdeveloped countries continue to face the burden of widespread illness causing pain, often attributed to factors like low nutrition and recurring infections, particularly vitamin A deficiency.

Methodology: This descriptive study employed a non probability convenient sampling technique and was conducted at the Urology Department of Lady Reading Hospital, Peshawar. The investigation spanned six months from January 25, 2019, to June 25, 2019. The study encompas sed a cohort of 369 patients, each subjected to comprehensive urine tests and detailed history and physical examinations. Procedures were performed under general anesthesia, utilizing Pediatric URS and pneumatic intracorporeal lithotripsy with Swiss lithoc last for bladder stone treatment. A 48 hour post treatment observation period assessed common intraoperative and postoperative consequences of transurethral pneumatic lithotripsy, including hematuria, bladder perforation, acute urine retention, and fever.

Results: Among the participants, 32% were female, and 68% were male. Notably, 5% experienced bladder perforation, 7% had hematuria, 4% exhibited acute urinary retention, and 7% presented with fever.

Conclusion: This study highlights complications of transurethral pneumatic lithotripsy in pediatric bladder stone disease, including bladder perforation, hematuria, acute urinary retention, and fever, providing crucial insights for clinical decisions.
ALIVE Biofeedback HRV training for Treating Insomnia: A Pilot Randomized Controlled Study.
Authors: Yusra Saleem  , Ujala Sajid  , Shamoon Noushad  , Sadaf Ahmed
Published: September 2023

Background: Insomnia is a common sleep disorder that affects a large portion of the population. While several treatments are available, such as medication and cognitive-behavioral therapy, some individuals may not respond well to these treatments. Biofeedback, a technique that provides individuals with real-time feedback on their physiological responses, has shown promise in treating insomnia. This study aimed to investigate the effectiveness of ALIVE biofeedback HRV training in treating insomnia.
Methodology: This pilot study utilized a randomized controlled trial design to investigate the efficacy of ALIVE biofeedback intervention in individuals diagnosed with insomnia. A total of 60 participants with insomnia were randomly assigned to either the ALIVE biofeedback or control group. The ALIVE biofeedback group received a six week intervention involving relaxation techniques, deep breathing exercises, and mindfulness meditation using the ALIVE Pioneer system for heart rate variability (HRV) biofeedback training. The control group received standard care for insomnia. Outcome measures included HRV parameters, blood pressure, the Pittsburgh Sleep Quality Index Japanese version (PSQI J), and the Insomnia Severity Index (ISI).
Results: The ALIVE biofeedback group showed significant improvements in heart rate variability (HRV) parameters, including increased SDNN and RMSSD and high-frequency power (HF) after the 6-week intervention. The control group did not display significant changes in HRV. Additionally, the ALIVE biofeedback group significantly decreased diastolic blood pressure. Regarding sleep outcomes, the ALIVE biofeedback group reported increased sleep duration and decreased sleep disturbances, as indicated by the PSQI-J scores. Furthermore, participants in the ALIVE biofeedback group significantly improved their ISI scores. These findings suggest that the ALIVE biofeedback intervention can potentially improve HRV, blood pressure, sleep quality, and insomnia severity in individuals with insomnia.
Conclusion: It is concluded from the study results that the ALIVE biofeedback training is a non-invasive and effective treatment for insomnia.
Metric theory of diophantine approximation and asymptotic estimates for the number of polynomials with given discriminants divisible by a large power of a prime number
Authors: Bernik V. I. , Vasilyev D. V. , Kalosha N. I. , Panteleeva Zh. I.
Published: September 2023

Discriminants of polynomials characterize the distribution of roots of polynomials in the complex plane. In recent years, for integer polynomials, exact lower-bound estimates have been obtained for the number of polynomials of a given degree and height. The method of obtaining these estimates is based on Minkowski’s theorems in the geometry of numbers and the metric theory of Diophantine approximation. A new method is proposed and allows one to obtain upperbound estimates for the number of polynomials with bounded discriminants in Archimedean and non-Archimedean metrics. The method generalizes the ideas of H. Davenport, B. Volkman, and V. Sprindzuk that allowed them to obtain significant advances in solving Mahler’s problem.
Crystal and magnetic structures of solid solutions based on BiFeO3
Authors: Karpinsky D. V. , Latushkа S. I. , Zheludkevich D. V. , Chobot A. N. , Kruplevich V. C. , Dolgiy V. K. , Latushkа T. V. , Neklyudov K. N. , Silibin M. V. , Budemko E. V.
Published: September 2023

The correlation between the multiphase state of the system and its magnetic properties was studied on Bi1–xEuxFeO3 ceramic samples in the range 0.12 ≤ x ≤ 0.18. The X-ray diffraction results indicate that, with an increase in the concentration of Eu ions, a structural transition from the rhombohedral (R3c) to nonpolar orthorhombic (Pnma) phase is observed through the partial formation of an antipolar orthorhombic structure (Pbam). The mixed phase state in the obtained compounds is observed in the range 0.12 ≤ x ≤ 0.16. Magnetic measurements in a strong magnetic field indicate a weak ferromagnetic interaction. The magnetic response in a strong field is explained by the location of the spins at the phase boundary, as well as by the presence of intrinsic antiferromagnetic spins.
Elastification of the arterial wall by high-intensity low-frequency ultrasound
Authors: Adzerikho I. E. , Kulak A. I. , Vladimirskaya T. E. , Leonchik T. V. , Chur S. N. , Minchenya V. T. , Shil’ko S. V.
Published: September 2023

A significant increase in the elasticity of the femoropopliteal artery segments in vitro was found as a result of the action of cavitation generated by powerful low-frequency (24–26 kHz) ultrasound introduced into the vessel by a flexible waveguide. The vessel elasticity was evaluated both by the deflection under the action of an external force and by the degree of its expansion vasodilatation by the internal pressure created by the expanding balloon. The possibility of achieving a more than two-fold decrease in the vascular wall elasticity modulus after 30-s exposure to an ultrasound intensity of 31 W/cm2 was shown. It has been established that at the 10 μm amplitude of ultrasonic vibrations, vascular wall damage occurs in the form of small foci of detachment and rupture of the intima accompanied by delamination in the media layer, when polymorphic slit-like cavities are formed with an increase in the amplitude of oscillations above 23 μm.
Anti-coronavirus properties of brassinosteroids
Authors: Zhabinskii V. N. , Matorin A. M. , Savinova O. V. , Boreko E. I. , Khripach V. A.
Published: September 2023

Antiviral properties of natural brassinosteroids of the campestane, ergostane, and stigmastane series (6-ketones and B-lactones) and their (22S,23S)-analogs were studied using the seasonal human respiratory alpha-coronavirus 229E (HCoV-229E) as an example. The presence of anticoronavirus properties was shown for a number of studied compounds. In general, 6-ketones were more active than B-lactones. The maximum inhibitory effect (EC50 21.1 µM) in relation to the reproduction of HCoV-229E was noted for (22S,23S)-epicastasterone.
Determining the methylation status of the promoter regions of MARCH11, HOXA9, PTGDR, and UNCX genes in patients with non-small cell lung cancer
Authors: Mikhalenka A. P. , Shchayuk A. N. , Nikitinskaya T. V. , Paliukhovich Yu. V. , Kubrak S. V. , Shapetska M. N. , Kilchevsky A. V.
Published: September 2023

The aim of this study was to determine the methylation status of the promoter regions of MARCH11, HOXA9, PTGDR, and UNCX genes in the tumor and non-tumor lung tissue in patients with non-small cell lung cancer (NSCLC). A relative level of methylation of the promoter regions of MARCH11, HOXA9, PTGDR, and UNCX genes was determined by the quantitative methylation-specific PCR in 73 patients with NSCLC. The quantitative methylation-specific reaction was performed both for tumor tissue samples and non-tumor tissue samples of the same patient. For each of the samples, a reaction was set both by the investigated genes (MARCH11, UNCX, HOXA9, and PTGDR) and by the reference beta-actin gene (β-actin). Positive levels of methylation of the HOXA9 gene were established for 83.5 % patients; the MARCH11 gene – for 80.8 % patients; the PTGDR gene – for 68.4 % patients; the UNCX gene – for 84.9 % patients. In the study group of patients with NSCLC, significant differences were found in the relative levels of methylation of the promoter regions of MARCH11, HOXA9, PTGDR, and UNCX genes in the tumor and non-tumor lung tissue. The data suggest that hypermethylation of MARCH11, HOXA9, PTGDR, and UNCX genes may play a role in NSCLC tumor progression.
Image analysis of brain cortex cells in vitro using deep learning method
Authors: Denisov A. A. , Nikiforov A. V. , Bahdanava A. V. , Pashkevich S. G. , Serdyuchenko N. S.
Published: September 2023

The article presents a method for analyzing images of cultured cortical cells for a quantitative analysis of the parameters of development of biological neural networks using machine learning approaches. We have developed software modules for segmentation of images into cells, clusters, and neurites using the neural network model and the deep learning method; a training set of images of cultivated neurons and corresponding segmentation masks have been generated. The results were validated by analyzing the development of cultivated neurons in vitro based on the length count of neutrites at different growth stages of the culture. The developed methods for monitoring the processes of formation of biological neuronal networks based on the analysis of the neuronal growth under different conditions and on different substrates provide an opportunity to monitor the processes of stem cell differentiation in the neurogenic direction. The results can be used in monitoring the formation of organoids in bioengineering applications, as well as in modeling the processes of nerve tissue regeneration.
Analysis of transformation of a thin graphite-like carbon layer on the detonation nanodiamond surface into diamond
Authors: Vityaz P. A. , Senyut V. T. , Parnitskiy A. M.
Published: September 2023

The article considers the process of obtaining nanostructured diamond materials due to phase transformation of thin films based on carbon non-diamond forms on the nanodiamond surface into diamond. For the synthesis of nanostructured diamond polycrystalline superhard material, various variants of the initial mixture based on nanodiamond with non-diamond carbon on the surface are proposed (surface-graphitized nanodiamond, surface-graphitized nanodiamond with addition of purified nanodiamond, detonation diamond-containing charge with a surface layer of “amorphous” carbon, including purified nanodiamond additives). The influence of the structure of a thin non-diamond layer on the parameters of graphite to diamond transition is revealed. For a carbon film with a disordered structure (the so-called “amorphous” carbon), the transition pressure to diamond will be about 10–15 GPa, which is significantly higher than the phase transformation pressure for thin graphite films in this temperature range. It is shown that the increase in the pressure of transformation of a thin layer of “amorphous” carbon is caused by its lower surface energy compared to the surface energy of graphite. It has been established that the region of transformation of a thin graphite-like film with a thickness of about 1 nm, formed on the 2–10 nm nanodiamond surface into diamond will be below the graphite-diamond equilibrium line in the temperature range of 1000– 2500 °C. Additional introduction of purified nanodiamond particles leads to a decrease in the pressure of transformation of thin layers of non-diamond carbon into a diamond structure from 10–15 to 2–7 GPa, which is due to the effect of the surface of catalytically active diamond nanoparticles on the thermodynamic stimulus of phase transformation.
Strength and crack resistance of cement composites under multilevel reinforcement
Authors: Zhdanok S. A. , Leonovich S. N. , Sadovskaya E. A. , Polonina E. N.
Published: September 2023

The working hypothesis is confirmed that the required fracture toughness of structural concrete can be provided by multi-level reinforcement: at the level of the crystalline joint of cement stone – carbon nanotubes, and at the level of fine-grained concrete – various macro-sized fiber fibers (steel, polymer). Reinforcement of a crystalline splice with carbon nanotubes leads to an increase in tensile strength by 20 %, an increase in Young’s modulus. With dispersed reinforcement of concrete modified with nanoparticles at the level of fine-grained concrete, the tensile strength increases by 109 %, the critical stress intensity coefficient (crack resistance index) increases by 280 % at normal separation, and by 48 % at transverse shear.
Indicators of zootechnical evaluation of fur coat and meat type sheep
Authors: Herman Yu. I. , Semchenko S. V. , Sheiko I. P.
Published: September 2023

Nowadays, due to the current economic situation in the Republic, the sheep breeding of Belarus is developing intensively, since there is a need for mutton in the global market. In some regions, work is already underway to create a promising herd of sheep with high meat productivity. An obligatory element of breeding activities is the evaluation of stud rams for the quality of the progeny, the accuracy of which determines the effectiveness of the selection process. The article contains the results on the development of zootechnical rules for evaluation of selection traits of the Romanov breed sheep that was conducted at the RUE “Vitebsk breeding enterprise”. The object of research was purebred Romanov breed animals that had been used in pedigree breeding since 2017. As a result of research, parameters for sheep ranking by a set of selection traits, algorithms for determining individual and complex estimated breeding values of rams, ewes, and young animals were developed. This will allow the most rational zootechnical measures and evaluation of fur coat and meat type breeding sheep.
Influence of interruptions in radiation therapy on long-term results of treatment of stage I-III head and neck cancers in the absence of surgical and chemoradiotherapy
Authors: Batyan A. N. , Valantsevich V. N. , Hancharova K. V. , Dziameshka P. D. , Lemiasheuski V. O.
Published: September 2023

Despite the fact that head and neck tumors are very sensitive to radiation treatment, patients who have completed a course of radiation therapy have a high rate of recurrence and mortality from the underlying disease.

The aim of the study was to analyze the event-free survival of patients who completed a course of radiation therapy for stage I-III head and neck cancer according to a radical program under the influence of a number of independent factors such as age, gender, total focal dose, disease stage, duration of a break in a split course of radiation therapy.

The effect of the duration of interruption on survival was assessed by analyzing the treatment regimens for patients who received radiation treatment for stage I-III head and neck cancer according to a radical program from 2016 to 2018 at the Brest Regional Oncological Dispensary. Statistical processing of the obtained data included the analysis by the Cox regression method. Data were analyzed using the Kaplan-Meier method to evaluate the outcome.

In the multivariate analysis, it was found that the disease stage has the greatest relationship with event-free survival (p < 0.01). The same trend is observed for the duration of interruption in radiotherapy (p < 0.05). The cumulative survival was significantly higher in the group of patients with treatment interruption of less than 3 weeks compared to the group of patients who completed treatment more than 3 weeks apart (80.00 % vs 49.06 %). If the duration of the break is less than 3 weeks, the clinical stage (T1-T3) is not a factor influencing patient survival.

Accounting for the effect of interruptions in the course of radiotherapy and the understanding the influence of controllable factors is essential for optimal treatment strategies.
Morphostructural changes in the brain of experimental animals after using mesenchymal stem cells in the temporomandibular joint inflammation model
Authors: Pashkevich S. G. , Rubnikovich S. P. , Kuznetsova T. E. , Kuzmenko E. V. , Mironova G. P. , Tikhonovich O. G. , Gladkova Zh. A. , Zhogal K. N. , Serdyuchenko N. S. , Grishchenkov A. S.
Published: September 2023

The article presents the results of structural and functional transformations in cerebellum, trigeminal nuclei, and hippocampus of male Wistar rats against the background of injection of mesenchymal stem cells (MSCs) into Meckel’s space in the temporomandibular joint (TMJ) inflammation model.

The aim of the study was to clarify the effect of MSCs injections into Meckel’s space on the morphostructural features of cerebellum, trigeminal nuclei, and hippocampus in the TMJ inflammation model.

Injecting the mesenchymal stem cells into Meckel’s space in an inflammatory model of the right lower temporomandibular joint promotes the structure restoration of the ganglionic layer of the cerebellum, the spinal nuclei of the trigeminal nerve, and the hippocampus of rats by the 28th day. This is manifested in increasing the neuronal density, decreasing the neurodegeneration index, and in activating glia elements.
Diagnostic significance of determining TREC and KREC T- and B-cell receptor rearrangement products in patients with inborn immune errors
Authors: Polyakova E. A. , Stegantseva M. V. , Guryanova I. E. , Lutskovich D. V. , Skapavets K. Y. , Liubushkin A. V. , Volodashchik T. P. , Kazak V. I. , Skibo Yu. V. , Belevtsev M. V.
Published: September 2023

Inborn immunity errors such as primary immunodeficiencies in children represent a significant problem for public health, and it is undeniably important to improve the laboratory diagnosis of this pathology by creating new, effective methods for early detection of disorders involving immune mechanisms.

The ROC analysis was used to evaluate the diagnostic significance of determining the copy number of T- and B-cell receptor DNA circle fragments (TREC/KREC) by multiplex real-time PCR in patients with a genetically determined diagnosis of primary immunodeficiency.

Peripheral blood DNA samples of healthy children (n = 98) aged 0.0 (0-15.0) years, who constituted the control group, and of patients with genetically confirmed primary immunodeficiency (n = 95) aged 7.2 (0.1-18.0) years were examined.

It has been established that determining the number of T and B cell receptor rearrangement products (TREC and KREC) has a high diagnostic significance in severe combined immunodeficiency, chromosomal instability syndromes such as ataxiateleangioectasia and Niimegen syndrome, diseases associated with immune dysregulation, agammoglobulinemia. Determining TREC and KREC is not informative in immunodeficiencies with non-lymphoid cell dysfunction or disorders that do not affect T- and B-cell receptor gene rearrangement such as the Wiskott-Aldrich syndrome and the chronic granulomatous disease.

Determining TREC, KREC has a high diagnostic significance and can be applied in diagnosis of congenital immunity errors associated with T- and B-cell lymphopenia.
Genealogical diagnostics of neoplasms based on artificial intelligence systems
Authors: Kuzniatsou A. E.
Published: September 2023

The compilation and analysis of the patient’s genealogies is one of the methods of population genetics, which makes it possible to identify a predisposition to a particular oncological pathology. At present, it is relevant to prove the feasibility of developing and introducing into clinical practice a comprehensive method for diagnosing and preventing tumors based on data from genetic counseling, molecular biological research and modern artificial intelligence technologies. An information-analytical system is proposed that allows analyzing the patient’s data obtained during the consultation, with the possibility of supplementing them with information from the medical history and the results of the study. The proposed information system is able to analyze of the genealogy and give a preliminary conclusion about the risk of a tumor process in the patient’s family members, according to the algorithms of the morbidity accumulated in the region.
Effect of proline-containing oligopeptides on the behavior of outbred ICR mice in the Forced Swim Test
Authors: Kravchenko E. V. , Olgomets L. M. , Savanets O. N. , Borodina K. V. , Pustyulga E. S. , Golubovich V. P. , Zilberman R. D. , Bizunok N. A. , Dubovik B. V.
Published: September 2023

The effect of proline-containing oligopeptides N-Ac-DSer-Pro-DArg-Gly-NH2 (B-4), N-Ac-Trp-Pro-Arg-Gly-NH2 (B-5), N-Ac-Tyr-Pro-Arg-Gly-NH2 (B-7), and Pro-Gly on the behavior of male ICR mice in the Forced Swim Test was studied. N-Ac-DSer-Pro-DArg-Gly-NH2 (1.0 mcg/kg, i.n) increased the intensity of active swimming, most pronounced – during the last 2 minutes of testing (maximum fatigue period), i.e., it prevented the behavior of “despair”.
Os Odontoideum - "MR documented Craniocervical Ligamentous Injury in Early Childhood with delayed formation of Os Odontoideum on Sequential Imaging". Case-based Review and Mini Database Analysis
Authors: Menezes Arnold H.
Published: September 2023

The etiology of os odontoideum has been debated ever since its first description by Giacomini in 1886. There are proponents of congenital origin as well as reports of post-traumatic os odontoideum formation after early childhood craniovertebral junction (CVJ) trauma. We document CVJ ligamentous injury on MRI in an 18-month-old child with sequential imaging demonstrating the os odontoid formation. Our database of 260 surgically treated patients with os odontoideum was analyzed regarding etiology and associated abnormalities. The literature (1970-2022) is reviewed.
IN SILICO STUDY OF DERIVATIVE COMPOUNDS OF GALANGAL PLANTS AS ANTI-INFLAMMATORY
Authors: Aryasa I Wayan Tanjung , Sugianta I Kadek Arya
Published: September 2023

Inflamasi merupakan dasar patogenesis dari beberapa penyakit baik penyakit bersifat degeneratif maupun non-degeneratif. Tumbuhan lengkuas yang umumnya terdapat di Indonesia biasa digunakan sebagai obat tradisional untuk beberapa penyakit dan juga memiliki senyawa metabolit sekunder yang bermanfaat sebagai antiinflamasi. Di dalam penelitian menggunakan pendekatan secara in silico berupa  docking molekuler yang telah diterapkan pada 5 senyawa turunan dari tumbuhan lengkuas ke target molekuler inflamasi penting seperti reseptor siklooksigenase-2 (COX-2). Analisis aktivitas biologis senyawa turunan dari tumbuhan lengkuas menggunakan server WAY2DRUG PASS prediction. Hasil prediksi sifat fisikokimia senyawa turunan dari tumbuhan lengkuas menggunakan server SWISS-ADME. Penelitian ini bertujuan untuk memprediksi kemampuan dari 5 senyawa turunan dari tumbuhan lengkuas dalam menghambat enzim COX-2. Informasi terperinci telah diperoleh dengan menggunakan pendekatan docking molekuler. Simulasi docking untuk 5 senyawa turunan dari tumbuhan lengkuas telah dilakukan melalui aplikasi Autodock 4.2 yang tertanam didalam aplikasi MGL Tools 1.5.6. Interaksi molekular senyawa turunan dari tumbuhan lengkuas terhadap reseptor COX-2 divisualisasikan menggunakan perangkat lunak Discovery Studio (Biova). Berdasarkan hasil penelitian yang telah dilaksanakan dapat disimpulkan bahwa senyawa uji Galanganal memiliki afinitas yang paling baik jika dibandingkan dengan senyawa Galanganol A, Galanganol B, Galanganol C dan Galangin. Hal tersebut dapat dilihat dari nilai energi bebas ikatannya sebesar -8,98 kcal/mol dan konstanta inhibisinya sebesar 261,59 nM. Hasil ini menunjukkan bahwa senyawa uji Galanganal memiliki potensi sebagai agen antiinflamasi. Namun, penelitian lanjutan adalah perlu mengkaji lebih banyak senyawa turunan dari tumbuhan lengkuas untuk mengisolasi konformasi yang terbaik.
Effectiveness of the Reading to Learn (R2L) Model on Scientific Literacy Skills on Static Electricity Topic
Authors: Arif Khairil , Rusma Olyivia Retdwina , Putri Aulia Musva , Azzahra Firda
Published: September 2023

The purpose of this study was to determine the difference in science learning outcomes between groups of students who participated in learning with the Reading to Learn (R2L) model and direct learning, by analyzing the literacy skills of class IX students at Junior High School in Bukittinggi, West Sumatra. The study population was all students of class IX and the sample class was selected by purposive sampling technique, so that class IX-6 was obtained as the experimental group and class IX-4 as the control group, with a sample of 56 students. This research is a quasi-experimental research with a pretest and posttest group design pattern. The data collected is a test of learning outcomes which are analyzed quantitatively to measure students' scientific literacy skills which are grouped into 3 aspects, namely numerical, conceptual, and multidimensional aspects. The instrument used is a scientific literacy test in the form of 10 description questions. The results show that the research hypothesis H1 is accepted because the table shows that t count > t table. This hypothesis test found that the application of the Reading to Learn (R2L) approach had an effect on students' scientific literacy skills. While the results of the experimental group N-Gain was 0.44 or 44% in the medium category (less effective). So we look at some of the factors causing it by giving questionnaires to students. Based on statistical calculations, the scores for each indicator in the questionnaire are 87.5% of students using local languages in daily conversation, reading time of 10-30 minutes is 46.88%, and courses or tutoring outside school hours are 28.13%.
Development of CORE-based Electronic-modules to Improve Students' Problem-Solving Skills
Authors: Malik Adam , Al-Hanafi Muhammad Algi , Chusni Muhammad Minan , Nugraha Andi Rohendi
Published: September 2023

Students must be trained and develop problem-solving skills as part of 21st-century skills. The study aims to determine the feasibility and implementation of learning CORE-based Electronic-modules and the improvement of students' problem-solving skills on impulse-momentum material. The research method used is Research and Development with the ADDIE model (Analysis, Design, Development, Implementation, and Evaluation). The instrument used is a validation sheet (expert of material and media and teachers), student worksheets, and tests. The results show CORE-based Electronic-modules after validation an average feasibility of 80% and the implementation of learning activities using CORE-based Electronic-modules an average of 84% including in the very good category. Student worksheets with an implementation percentage of 81% with effective criteria Enhancing students' problem-solving skills of 0.64 with moderate interpretation. The results of hypothesis testing using a paired obtained a tcount of 31.00 > ttable of 2.04. The results show there are differences in problem-solving skills after the implementation of CORE-based electronic modules. The CORE-based electronic modules are feasible to use in the classroom learning process and can improve students' problem-solving skills on impulse-momentum material
Training and Working Environment on Science Teachers’ Performance
Authors: Sihombing Humiras Betty Marlina , Sherly  , Dharma Edy , Purba Desmalia , Kisno
Published: September 2023

The objective of this study was to gain a deeper understanding of the training, working conditions, and performance of sains teachers at Sultan Agung Pematang Siantar Private High School, as well as to explore the impact of these factors on teacher performance. The study utilized both field research and a review of existing literature. The sample for the study consisted of thirty-seven (37) teachers from Sultan Agung Pematang Siantar Private School. The study's data comprised quantitative and qualitative information from primary and secondary sources. Data collection was carried out through surveys, interviews, and examination of relevant documents. Various analytical methods including qualitative descriptive analysis, quantitative descriptive analysis, and normality tests were employed to analyze the data. The findings of the study revealed that teacher performance at Sultan Agung Pematang Siantar Private Elementary and High School was rated as high, indicating that training and working conditions played a significant and positive role in the success of science teachers.
Analysis of The Nature of Science in The Prototype Curriculum Based on Social and Science Students’ Book for Fourth Grade Phase B
Authors: Pratiwi Dini Aulia , Sopandi Wahyu , Pangesty Desy Ayu Ratna
Published: September 2023

The Nature of Science or NOS is knowledge that explains how science works and how scientists conduct research. NOS has aspects of form, namely products, processes and properties. The preparation stage, such as reviewing the literature on the NOS aspect and determining the NOS aspect used, namely from the form aspect, including products, processes, attitudes, and from the nature aspect, in the form of empirical, tentative methods, subjective, creative, theoretical and legal, socio-cultural, and scientific; The analysis stage, by analyzing the basic competencies and content in the curriculum and its embodiment in student books. This research was carried out with the following steps: Based on the results of the researchers' agreement, the minimum value limit in the data analysis process is 80%. Based on the results of the analysis, it is shown that the aspects and embodiments of the nature of science and the nature of the science books for fourth grade students are not explicitly explained. The excellent category is in the product aspect with an average percentage of >80%. While other aspects have a very less category with a percentage of <80%, even some aspects have an average percentage of <1%.
Teacher and Parent Perceptions of Student's Learning Loss in Post-Pandemic Science Learning
Authors: Hamidi Azrul , Jumadi Jumadi , Nurohman Sabar , Febrian Andika
Published: September 2023

This study aims to see how teachers and parents perceive learning loss of students after the pandemic, especially in junior high school science lessons. The research method uses a qualitative approach with the qualitative data analysis model used is Miles and Huberman, includes data collection, data reduction, data display, and conclusion. The study result that students have started to forget the atmosphere of brave learning, but habits such as wanting to easily get lesson results are still carried over to this day. Parents also feel that their children have revived their interest, motivation and learning outcomes when compared to the pandemic two years ago. The existence of online learning has an impact on learning, especially interest, motivation, and student learning outcomes. This impact has even caused learning loss for students until after the pandemic. Although slowly but surely, students' interest and learning motivation began to show an increase in line with the return to normal face-to-face learning.
Development of Science Learning Media Assisted by Ethno-Vlog Sisingaan and Gembyung Dance to Improve Creative Thinking Skills
Authors: Gumilar Nyi Mas Ayu Ratna , Sudarmin  , Marwoto Putut
Published: September 2023

This study aims to develop a product in the form of Ethno-Vlog learning media for Class IV SD science learning as an effort to improve students' creative thinking skills. The Ethno-Vlog learning media contains Sisingaan and Gembyung dance with style and motion material content. This research uses the ADDIE development model (Analyze, Design, Development, Implementation, and Evaluation). Thus the realization of the purpose of this research is to determine the feasibility test of the media, the practicality test, and the effectiveness of using Ethno-Vlog learning media. The development of learning media based on Ethno-Vlog Sisingaan and Gembyung dance for grade IV SD obtained the proper category from the two validators. The results of the student response questionnaire on the small-scale test were 90% and the response questionnaire from the teacher obtained 86% results indicating that learning media was very feasible to use. As for the effectiveness of using Ethno-Vlog-based learning media in improving creative thinking skills, the results are 0.60 in the moderate or effective category. The media is following the objectives of learning practices in the Independent Curriculum as well as efforts to shape the character of students and develop creative thinking skills contained in one of the dimensions of the Pancasila learner profile.