bluuebunny/crossref_metadata_2025 huggingface dataset:
A New Design of Tubular Ceramic Membrane Module for Oily Water Treatment: Multiphase Flow Behavior and Performance Evaluation
Authors: Oliveira Neto Guilherme L. , Oliveira Nívea G. N. , Delgado João M. P. Q. , Nascimento Lucas P. C. , Gomez Ricardo S. , Cabral Adriano S. , Cavalcante Daniel C. M. , Miranda Vansostenes A. M. , Farias Neto Severino R. , Lima Antonio G. B.
Published: December 2020

Petroleum has been extracted from oil reservoirs using different techniques. This activity is accompanied for a large amount of water and sometimes mixed with gas. This produced water has a high oil concentration and other toxic chemical compounds, thus, it must be treated to be reused or released to environment according to environmental protection regulations. Currently, ceramic membrane technology has been employed in the wastewater treatment, due to its high benefit–cost ratio. In this sense, this work aims to study the oil–water mixture separation process using a new configuration of tubular ceramic membrane module by computational fluid dynamic (ANSYS Fluent software). The proposed model is composed of mass and linear momentum conservation equations coupled to Darcy’s law and SST k-ω turbulence model. Results of the volumetric fraction, pressure, and velocity distribution of the oil and water phases are presented and discussed. The results indicated that the proposed model and new device both have great potential to be used on the water/oil separation process and that the transmembrane pressure remains constant in the axial direction and decreases radially through the membranes, indicating an efficient system that favors the transport of clean water and oil retention.
Microstructures and Mechanical Properties of Precipitation-Hardenable Magnesium–Silver–Calcium Alloy Sheets
Authors: Bian Mingzhe , Huang Xinsheng , Chino Yasumasa
Published: December 2020

Precipitation hardening provides one of the most common strengthening mechanisms for magnesium (Mg) alloys. Here, we report a new precipitation-hardenable Mg sheet alloy based on the magnesium–silver–calcium system. In a solution treated condition (T4), the strength of Mg–xAg–0.1Ca alloys is enhanced with increasing the Ag content from 1.5 wt.% to 12 wt.%. The Mg–12Ag–0.1Ca (wt.%) alloy sheet shows moderate tensile yield strengths of 193 MPa, 130 MPa, 117 MPa along the rolling direction (RD), 45° and transverse direction (TD) in the T4-treated condition. Subsequent artificial aging at 170 °C for 336 h (T6) increases the tensile yield strengths to 236 MPa, 163 MPa and 143 MPa along the RD, 45° and TD, respectively. This improvement in the tensile yield strength by the T6 treatment can be ascribed to the formation of AgMg4 precipitates lying on the {112¯0}ɑ and pyramidal planes. Our finding is expected to stimulate the development of precipitation-hardenable Mg–Ag-based wrought alloys with high strength.
Change of Microstructure and Hardness of Duo-Casted Al3003/Al4004 Clad Material during Extrusion Process
Authors: Lee Jin-Kyung , Lee Sang-Pill , Lee Jong-Sup , Lee Sangmok , Jo Ilguk , Bae Dong-Su
Published: December 2020

This study was carried out to observe and measure the microstructure, distance between dendrite arms, aspect ratio, and Knoop hardness change of extruded material formed by the hydro co-extrusion of Al3003/Al4004 clad material manufactured by the duo-casting method. The specimen of duo-casted Al3003/Al4004 clad materials was circle shaped; it was composed of Al3003 (outside) and Al4004 (inside) materials. The manufacturing conditions of the hydro co-extruded specimen were 423 K temperature and 6.5 ratio of extrusion. At the interface of the duo-casted Al3003/Al4004 clad material, a non-junction at the interface and non-metallic inclusions of Si- and Mn-based oxides were observed. Al3003 exhibits equiaxed crystals; Al4004 has a casted structure with dendrites before extrusion, showed slight deformation during extrusion, and then finally exhibited completely deformed structures after extrusion. In the cast material, the distance between dendrite arms increased, and the aspect ratio of dendrites tended to decrease from the surface to the center. However, in the case of the extruded material, neither Al3003 nor Al4004 changed significantly from the surface to the inside. As extrusion progressed, the Knoop hardness value at the interface of Al3003/Al4004 increased rapidly compared with those of Al3003 and Al4004 matrixes.
Nature Inspired MIMO Antenna System for Future mmWave Technologies
Authors: Rahman Saifur , Ren Xin-cheng , Altaf Ahsan , Irfan Muhammad , Abdullah Mujeeb , Muhammad Fazal , Anjum Muhammad Rizwan , Mursal Salim Nasar Faraj , AlKahtani Fahad Salem
Published: December 2020

In this work, a new Multiple Input Multiple Output (MIMO) antenna system with a novel shape inspired by nature is proposed for Fifth-Generation (5G) communication systems. The antenna is designed on a Rogers 5880. The dielectric constant of the substrate is 2.2, and the loss tangent is assumed to be 0.0009. The gain of the system for the desired bandwidth is nearly 8 dB. The simulated and the measured efficiency of the proposed system is 95% and 80%, respectively. To demonstrate the capability of the system as a potential candidate for future 5G communication devices, MIMO key performance parameters such as the Envelope Correlation Coefficient (ECC) and Diversity Gain (DG) are computed. It is found that the proposed system has low ECC, constant DG, and high efficiency for the desired bandwidth.
Combining Biocontrol Agents with Chemical Fungicides for Integrated Plant Fungal Disease Control
Authors: Ons Lena , Bylemans Dany , Thevissen Karin , Cammue Bruno P.A.
Published: December 2020

Feeding a rising population of currently 7.8 billion people globally requires efficient agriculture, which is preferably sustainable. Today, farmers are largely dependent on synthetic fungicides to avoid food losses caused by fungal diseases. However, the extensive use of these has resulted in the emergence of fungicide-resistant pathogens and concerns have been raised over the residual effects on the environment and human health. In this regard, biocontrol agents (BCAs) have been proposed as an alternative to standard fungicides but their disease management capacity is usually incomplete and heavily relies on uncontrollable environmental conditions. An integrated approach combining BCAs with fungicides, which is the focus of this review, is put forward as a way to reduce the fungicide doses to manage plant diseases and thereby their residue on harvested crops. In addition, such a strategy of combining antifungal treatments with different modes of action reduces the selection pressure on pathogens and thereby the chances of resistance development. However, to allow its large-scale implementation, further knowledge is needed, comprising timing, number and interval of repeated BCA applications and their compatibility with fungicides. The compatibility of BCAs with fungicides might differ when applied in a mixture or when used in alternation.
Comparison of the Decay Behavior of Two White-Rot Fungi in Relation to Wood Type and Exposure Conditions
Authors: Bari Ehsan , Daniel Geoffrey , Yilgor Nural , Kim Jong Sik , Tajick-Ghanbary Mohammad Ali , Singh Adya P. , Ribera Javier
Published: December 2020

Fungal wood decay strategies are influenced by several factors, such as wood species, moisture content, and temperature. This study aims to evaluate wood degradation characteristics of spruce, beech, and oak after exposure to the white-rot fungi Pleurotusostreatus and Trametesversicolor. Both fungi caused high mass losses in beech wood, while spruce and oak wood were more resistant to decay. The moisture content values of the decayed wood correlated with the mass losses for all three wood species and incubation periods. Combined microscopic and chemical studies indicated that the two fungi differed in their decay behavior. While T. versicolor produced a decay pattern (cell wall erosion) typical of white-rot fungi in all wood species, P. ostreatus caused cell wall erosion in spruce and beech and soft-rot type I (cavity formation) decay in oak wood. These observations suggest that P. ostreatus may have the capacity to produce a wider range of enzymes/radicals triggered by the chemical composition of wood cell walls and/or local compositional variability within the cell wall.
Bioreactivity, Guttation and Agents Influencing Surface Tension of Water Emitted by Actively Growing Indoor Mould Isolates
Authors: Andersson Maria A. , Salo Johanna , Kedves Orsolya , Kredics László , Druzhinina Irina , Kurnitski Jarek , Salonen Heidi
Published: December 2020

The secretion of metabolites in guttation droplets by indoor moulds is not well documented. This study demonstrates the guttation of metabolites by actively growing common indoor moulds. Old and fresh biomasses of indoor isolates of Aspergillus versicolor, Chaetomium globosum, Penicillium expansum, Trichoderma atroviride, T. trixiae, Rhizopus sp. and Stachybotrys sp. were compared. Metabolic activity indicated by viability staining and guttation of liquid droplets detected in young (<3 weeks old) biomass were absent in old (>6 months old) cultures consisting of dehydrated hyphae and dormant conidia. Fresh (<3 weeks old) biomasses were toxic more than 10 times towards mammalian cell lines (PK-15 and MNA) compared to the old dormant, dry biomasses, when calculated per biomass wet weight and per conidial particle. Surfactant activity was emitted in exudates from fresh biomass of T. atroviride, Rhizopus sp. and Stachybotrys sp. Surfactant activity was also provoked by fresh conidia from T. atroviride and Stachybotrys sp. strains. Water repealing substances were emitted by cultures of P. expansum, T. atroviride and C. globosum strains. The metabolic state of the indoor fungal growth may influence emission of liquid soluble bioreactive metabolites into the indoor air.
Trace Elements and Sulfur Isotopes of Sulfides in the Zhangquanzhuang Gold Deposit, Hebei Province, China: Implications for Physicochemical Conditions and Mineral Deposition Mechanisms
Authors: Zhen Shimin , Wang Dazhao , Yu Xiaofei , Wang Qingfei , Li Yongsheng , Zha Zhongjian , Wang Jiang
Published: December 2020

The Zhangquanzhuang gold deposit is a special deposit in the Zhangjiakou district, on the northern margin of the North China Craton. It is characterized by the enrichment of sulfides, the scarcity of tellurides and zero to positive sulfur isotope compositions compared with the famous Dongping and Xiaoyingpan Te-Au-Ag deposit types of the same district. In this paper, we use the in-situ LA-(MC)-ICP-MS and bulk trace element concentrations of pyrite, and in-situ sulfur isotope compositions of sulfides, to study physicochemical conditions and mechanisms of mineral deposition in the Zhangquanzhuang deposit. Pyrite from stage I (PyI) contains high Te contents, pyrite from stage II (PyII) has the highest Co and Ni contents, and pyrite from stage III (PyIII) contains high Cr, Zn, Pb, Ag, Cu, Sb, Bi and Au contents. The calculated in-situ δ34SH2S values range from 0.9‰ to 6.1‰, and the values for stages I and II are higher than those for stage III. The mineral assemblages and trace element contents in pyrite show that large amounts of metals precipitated during stage III, in which the pH and logfO2 were constrained within the range of 4.1 to 5.2 and −36.9 to −32.1, respectively. Sulfidation and boiling derived from decreasing pressure may be the main mechanisms leading to mineral deposition in stage III. The Zhangquanzhuang gold deposit was formed in a mineral system that was different from the one that formed the Dongping and Xiaoyingpan Te-Au-Ag deposits, and should thus be called the “Zhangquanzhuang−type” deposit and considered a third gold deposit type in the Zhangjiakou ore field.
Active Manipulation of the Spin and Orbital Angular Momentums in a Terahertz Graphene-Based Hybrid Plasmonic Waveguide
Authors: Wang Ziang , Tan Qilong , Liang Yong , Zhou Xia , Zhou Wen , Huang Xuguang
Published: December 2020

Angular momentums (AMs) of photons are crucial physical properties exploited in many fields such as optical communication, optical imaging, and quantum information processing. However, the active manipulation (generation, switching, and conversion) of AMs of light on a photonic chip remains a challenge. Here, we propose and numerically demonstrate a reconfigurable graphene-based hybrid plasmonic waveguide (GHPW) with multiple functions for on-chip AMs manipulation. Its physical mechanism lies in creating a switchable phase delay of ±π/2 between the two orthogonal and decomposed linear-polarized waveguide modes and the spin-orbit coupling in the GHPW. For the linear-polarized input light with a fixed polarization angle of 45°, we can simultaneously switch the chirality (with −ħ/+ħ) of the transverse component and the spirality (topological charge ℓ = −1/+1) of the longitudinal component of the output terahertz (THz) light. With a switchable phase delay of ±π in the GHPW, we also developed the function of simultaneous conversion of the charity and spirality for the circular-polarized input light. In addition, a selective linear polarization filtering with a high extinction ratio can be realized. With the above multiple functions, our proposed GHPWs are a promising platform in AMs generation, switching, conversion, and polarization filtering, which will greatly expand its applications in the THz photonic integrated circuits.
Entrapment of Hydrophobic Biocides into Cellulose Acetate Nanoparticles by Nanoprecipitation
Authors: Cordt Cynthia , Meckel Tobias , Geissler Andreas , Biesalski Markus
Published: December 2020

This contribution reports an efficient method for the production and use of biocide-loaded cellulose acetate nanoparticles. As well-known model biocides 4-Hexylresorcinol and Triclosan were used for in situ nanoparticle loading during a nanoprecipitation process. We show that the nanoparticle size can be well-controlled by variation of the cellulose acetate concentration during nanoprecipitation. Apart from strong evidence suggesting cellulose acetate particle formation according to a nucleation-aggregation mechanism, we further show that the biocide loading of the particles occurs by a diffusion process and not via co-precipitation. The quantity of particle loading was analyzed by 1H-NMR spectroscopy of re-dissolved nanoparticles, and it was observed that a decisive factor for high packaging efficiency is the use of a biocide with low water solubility and high hydrophobicity. SEM studies showed no influence on the particle morphology or size by both biocides 4-Hexylresorcinol and Triclosan. Finally, an aqueous nanoparticle dispersion can be coated onto model paper sheets to yield pronounced antimicrobial surface-properties. Nanoparticles loaded with the biocide Triclosan showed a high antimicrobial activity against Bacillus subtilis, a cellulase producing bacteria, if applied to model paper substrates, even at extremely low coating weights of 1–5 g/m2, respectively. Additional long-term efficacy renders these nanoparticles ideal for various applications.
Undernutrition, Sarcopenia, and Frailty in Fragility Hip Fracture: Advanced Strategies for Improving Clinical Outcomes
Authors: Inoue Tatsuro , Maeda Keisuke , Nagano Ayano , Shimizu Akio , Ueshima Junko , Murotani Kenta , Sato Keisuke , Tsubaki Atsuhiro
Published: December 2020

Geriatric patients with hip fractures often experience overlap in problems related to nutrition, including undernutrition, sarcopenia, and frailty. Such problems are powerful predictors of adverse responses, although few healthcare professionals are aware of them and therefore do not implement effective interventions. This review aimed to summarize the impact of undernutrition, sarcopenia, and frailty on clinical outcomes in elderly individuals with hip fractures and identify successful strategies that integrate nutrition and rehabilitation. We searched PubMed (MEDLINE) and Cochrane Central Register of Controlled Trials (CENTRAL) for relevant literature published over the last 10 years and found that advanced interventions targeting the aforementioned conditions helped to significantly improve postoperative outcomes among these patients. Going forward, protocols from advanced interventions for detecting, diagnosing, and treating nutrition problems in geriatric patients with hip fractures should become standard practice in healthcare settings.
Computed-Tomography Body Composition Analysis Complements Pre-Operative Nutrition Screening in Colorectal Cancer Patients on an Enhanced Recovery after Surgery Pathway
Authors: Klassen Pamela , Baracos Vickie , Gramlich Leah , Nelson Gregg , Mazurak Vera , Martin Lisa
Published: December 2020

Pre-operative nutrition screening is recommended to identify cancer patients at risk of malnutrition, which is associated with poor outcomes. Low muscle mass (sarcopenia) and lipid infiltration to muscle cells (myosteatosis) are similarly associated with poor outcomes but are not routinely screened for. We investigated the prevalence of sarcopenia and myosteatosis across the nutrition screening triage categories of the Patient-Generated Subjective Global Assessment Short Form (PG-SGASF) in a pre-operative colorectal cancer (CRC) cohort. Data were prospectively collected from patients scheduled for surgery at two sites in Edmonton, Canada. PG-SGASF scores ≥ 4 identified patients at risk for malnutrition; sarcopenia and myosteatosis were identified using computed-tomography (CT) analysis. Patients (n = 176) with a mean age of 63.8 ± 12.0 years, 52.3% male, 90.3% with stage I–III disease were included. Overall, 25.2% had PG-SGASF score ≥ 4. Sarcopenia alone, myosteatosis alone or both were identified in 14.0%, 27.3%, and 6.4% of patients, respectively. Sarcopenia and/or myosteatosis were identified in 43.4% of those with PG-SGASF score < 4 and in 58.5% of those with score ≥ 4. Overall, 32.9% of the cohort had sarcopenia and/or myosteatosis with PG-SGASF score < 4. CT-defined sarcopenia and myosteatosis are prevalent in pre-operative CRC patients, regardless of the presence of traditional nutrition risk factors (weight loss, problems eating); therefore, CT image analysis effectively adds value to nutrition screening by identifying patients with other risk factors for poor outcomes.
Explorative Screening of Bioactivities Generated by Plant-Based Proteins after In Vitro Static Gastrointestinal Digestion
Authors: Dugardin Camille , Cudennec Benoit , Tourret Mélissa , Caron Juliette , Guérin-Deremaux Laetitia , Behra-Miellet Josette , Lefranc-Millot Catherine , Ravallec Rozenn
Published: December 2020

The gastrointestinal digestion of food proteins can generate peptides with a wide range of biological activities. In this study, we screened various potential bioactivities generated by plant-based proteins. Whey protein as an animal protein reference, five grades of pea protein, two grades of wheat protein, and potato, fava bean, and oat proteins were submitted to in vitro SGID. They were then tested in vitro for several bioactivities including measures on: (1) energy homeostasis through their ability to modulate intestinal hormone secretion, to inhibit DPP-IV activity, and to interact with opioid receptors; (2) anti-hypertensive properties through their ability to inhibit ACE activity; (3) anti-inflammatory properties in Caco-2 cells; (4) antioxidant properties through their ability to inhibit production of reactive oxygen species (ROS). Protein intestinal digestions were able to stimulate intestinal hormone secretion by enteroendocrine cells, to inhibit DPP-IV and ACE activities, to bind opioid receptors, and surprisingly, to decrease production of ROS. Neither pro- nor anti-inflammatory effects have been highlighted and some proteins lost their pro-inflammatory potential after digestion. The best candidates were pea, potato, and fava bean proteins.
Free Sugar Consumption and Obesity in European Adolescents: The HELENA Study
Authors: Flieh Sondos M. , Moreno Luis A. , Miguel-Berges María L. , Stehle Peter , Marcos Ascensión , Molnár Dénes , Widhalm Kurt , Béghin Laurent , De Henauw Stefaan , Kafatos Anthony , Leclercq Catherine , Gonzalez-Gross Marcela , Dallongeville Jean , Molina-Hidalgo Cristina , González-Gil Esther M.
Published: December 2020

Few studies have evaluated the association between dietary free sugars intake (FSI) and obesity in adolescents. We examined the relation between FSI and their contributors from the main food groups and obesity in European adolescents. We included 843 adolescents (51.6% male) from the cross-sectional HELENA study with two completed 24 h recalls and anthropometric data. Linear mixed models were applied to investigate the relation between FSI and different anthropometric indices. Odds ratios for having a high body mass index (BMI) were also estimated by multilevel ordinal regression. Total FSI was higher in males than females (102.60 g and 87.58 g, respectively, p < 0.001). No effect was observed between free sugar from the main food groups and BMI. Consumers of FSI from “cakes, pies and biscuits” in males (odd ratio (OR) = 0.455; 95% Confidence interval (CI) 0.251, 0.824) and from “breakfast cereals” in females had a lower probability of having obesity (OR = 0.423; 95%CI 0.204, 0.878), whereas females consuming FSI from ‘fruit and vegetables juices’ had a higher probability of obesity (OR= 2.733; 95% CI 1.286, 5.810). This study provides no evidence that increased FSI is associated with obesity in adolescents. Further studies are needed to assess the longitudinal exposure to FSI and their effect on obesity development.
Plasma and Red Blood Cell PUFAs in Home Parenteral Nutrition Paediatric Patients—Effects of Lipid Emulsions
Authors: Lezo Antonella , D’Onofrio Valentina , Puccinelli Maria Paola , Capriati Teresa , De Francesco Antonella , Bo Simona , Massarenti Paola , Gandullia Paolo , Marin Marta , Derevlean Liliana , Baldini Letizia , Longo Filomena , Diamanti Antonella
Published: December 2020

Background: Mixed lipid emulsions (LE) containing fish oil present several advantages compared to the sole soybean oil LE, but little is known about the safety of essential fatty acids (EFA) profile in paediatric patients on long-term Parenteral Nutrition (PN). Aim of the study: to assess glycerophosfolipid polyunsaturated fatty acids (PUFA) levels on plasma and red blood cell (RBC) membrane of children on long term PN with composite LE containing fish oil (SMOF), and to compare it with a group receiving olive oil LE (Clinoleic®) and to the reference range for age, previously determined on a group of healthy children. Results: A total of 38 patients were enrolled, median age 5.56 (0.9–21.86) years, 15 receiving Clinoleic®, 23 receiving SMOF. Patients on SMOF showed significantly higher levels of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), lower levels of arachidonic acid (ARA) and Mead acid (MEAD)/ARA ratio in plasma and RBC compared with patients on Clinoleic® and with healthy children. Triene:tetraene (T:T) ratio of both groups of patients did not differ from that of healthy children-median plasma (MEAD/ARA: 0.01, interquartile rage (IQR) 0.01, p = 0.61 and 0.02, IQR 0.02, p = 0.6 in SMOF and Clinoleic® patients, respectively), and was considerably lower than Holman index (>0.21). SMOF patients showed no statistically significant differences in growth parameters compared with Clinoleic® patients. Patients of both groups showed stiffness class F0-F1 of liver stiffness measure (LSM) 5.6 (IQR 0.85) in SMOF patients and 5.3 (IQR 0.90) in Clinoleic® patients, p = 0.58), indicating absence of liver fibrosis. Conclusions: Fatty acids, measured as concentrations (mg/L), revealed specific PUFA profile of PN patients and could be an accurate method to evaluate nutritional status and eventually to detect essential fatty acid deficiency (EFAD). SMOF patients showed significantly higher EPA, DHA and lower ARA concentrations compared to Clinoleic® patients. Both LEs showed similar hepatic evolution and growth.
The Specific Carbohydrate Diet and Diet Modification as Induction Therapy for Pediatric Crohn’s Disease: A Randomized Diet Controlled Trial
Authors: Suskind David L. , Lee Dale , Kim Young-Mo , Wahbeh Ghassan , Singh Namita , Braly Kimberly , Nuding Mason , Nicora Carrie D. , Purvine Samuel O. , Lipton Mary S. , Jansson Janet K. , Nelson William C.
Published: December 2020

Background: Crohn’s disease (CD) is a chronic inflammatory intestinal disorder associated with intestinal dysbiosis. Diet modulates the intestinal microbiome and therefore has a therapeutic potential. The aim of this study is to determine the potential efficacy of three versions of the specific carbohydrate diet (SCD) in active Crohn’s Disease. Methods: 18 patients with mild/moderate CD (PCDAI 15–45) aged 7 to 18 years were enrolled. Patients were randomized to either SCD, modified SCD(MSCD) or whole foods (WF) diet. Patients were evaluated at baseline, 2, 4, 8 and 12 weeks. PCDAI, inflammatory labs and multi-omics evaluations were assessed. Results: Mean age was 14.3 ± 2.9 years. At week 12, all participants (n = 10) who completed the study achieved clinical remission. The C-reactive protein decreased from 1.3 ± 0.7 at enrollment to 0.9 ± 0.5 at 12 weeks in the SCD group. In the MSCD group, the CRP decreased from 1.6 ± 1.1 at enrollment to 0.7 ± 0.1 at 12 weeks. In the WF group, the CRP decreased from 3.9 ± 4.3 at enrollment to 1.6 ± 1.3 at 12 weeks. In addition, the microbiome composition shifted in all patients across the study period. While the nature of the changes was largely patient specific, the predicted metabolic mode of the organisms increasing and decreasing in activity was consistent across patients. Conclusions: This study emphasizes the impact of diet in CD. Each diet had a positive effect on symptoms and inflammatory burden; the more exclusionary diets were associated with a better resolution of inflammation.
Acer tegmentosum Maxim Inhibits Adipogenesis in 3t3-l1 Adipocytes and Attenuates Lipid Accumulation in Obese Rats Fed a High-Fat Diet
Authors: Cho Hang-Hee , Lee Soo-Jung , Kim Sung-Ho , Jang Sun-Hee , Won Chungkil , Kim Hong-Duck , Kim Tae Hoon , Cho Jae-Hyeon
Published: December 2020

We investigated the effect of Acer tegmentosum Maxim (ATM) on adipocyte differentiation in 3T3-L1 cells and anti-obesity properties in obese rats fed a high-fat diet (HFD). Cellular lipid content in DMI (dexamethasone, 3–isobutyl–1–methylxanthine, and insulin mixture)-treated cells increased, while ATM treatment caused a significant reduction in lipid accumulation in differentiated 3T3-L1 cells. ATM (60 ug/mL) caused inhibition of adipogenesis via down-regulation of the CCAAT/enhancer binding protein β (C/EBPβ) (48%), C/EBPα (66%), and peroxisome proliferator-activated receptor γ (PPARγ) (64%) expressions in 3T3-L1 cells. Moreover, ATM induced a decrease in the expressions of adipocyte-specific genes, such as adipocyte fatty acid-binding protein-2 (aP2), fatty acid synthase (FAS), and lipoprotein lipase (LPL). Protein kinase B (Akt) and glycogen synthase kinase 3β (GSK3β) phosphorylation was also decreased by ATM treatment of 3T3-L1 adipocytes. We investigated the anti-obesity effects of ATM on HFD-induced obese rats. Rats fed with an HFD demonstrated elevations in body weight gain, while the administration of ATM reversed body weight (BW) gains and adipose tissue weights in rats fed an HFD. ATM supplementation caused a decrease in the circulating triglyceride and total cholesterol levels and led to inhibition of lipid accumulation in the adipose tissues in HFD-induced obese rats. Epididymal fat exhibited significantly larger adipocytes in the HFD group than it did in the ATM-treated group. These results demonstrate that ATM administration caused a reduction in adiposity via attenuation in adipose tissue mass and adipocyte size.
Dietary Interventions to Promote Healthy Eating among Office Workers: A Literature Review
Authors: Glympi Alkyoni , Chasioti Amalia , Bälter Katarina
Published: December 2020

Our aim is to review published studies on dietary interventions to promote healthy eating habits among office workers. The databases PubMed, EBSCO (MEDLINE, Academic Search Elite, CINAHL Plus, PsycARTICLES, PsycINFO), Cochrane Library, SCOPUS, and Google Scholar were searched between February and April 2019. Initially, 6647 articles were identified, and the final number of articles that met the inclusion criteria was 25. We identified four different types of interventions that included educational and/or environmental components, where environmental components provided healthy food in a work-related context. The interventions at the offices included web-based material, availability of food, provision of information in various ways, and a combination of environmental, educational and theory-based psychological approaches (i.e., multicomponent). The most commonly used designs were web-based and information interventions, respectively, which are the least expensive ways to intervene. The interventions assessed a range of outcomes, but this literature review focused on three, i.e., dietary intake, dietary behavior and health-related outcomes. Although the studies were heterogenous in terms of outcomes, design, number of participants, gender distribution and duration, all studies reported at least one positive effect. Thus, workplace dietary interventions are an unutilized area to positively influence dietary intake and health outcomes among office workers. However, the intervention needs to be tailored to the workplace.
Whole Grains, Refined Grains, and Cancer Risk: A Systematic Review of Meta-Analyses of Observational Studies
Authors: Gaesser Glenn A.
Published: December 2020

PubMed, Web of Science, and the Cochrane Database of Systematic Reviews were searched for meta-analyses that provided risk estimates (±95% confidence intervals) for associations between intakes of whole and refined grains and risk of total and site-specific cancer. The preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines were followed. Only meta-analyses that included whole grains and refined grains as separate food groups, and not as part of dietary patterns, were included. A total of 17 publications were identified that met inclusion criteria. Within these, results from a total of 54 distinct meta-analyses were reported for whole grains and 5 meta-analyses for refined grains. For total cancer mortality, 7 meta-analyses of cohort studies indicated that whole grain intake was associated with 6% to 12% lower risk in comparison of highest vs. lowest intake groups, and 3% to 20% lower risk for doses ranging from 15 to 90 g/day. For site-specific cancers, meta-analyses indicated that whole grain intake was consistently associated with lower risks of colorectal, colon, gastric, pancreatic, and esophageal cancers. Limited data were available for refined grains, with only 4 publications providing risk estimates, and only 1 of the meta-analyses included more than 3 studies. High intake of refined grains was associated with increased risk of colon and gastric cancer. By contrast, in the only dose-response meta-analysis, each 90 g/day consumption of refined grains was associated with a 6% lower risk of total cancer. In addition to the limited number of published meta-analyses on refined grains, results were also weakened due to the fact that refined grains were frequently defined to include both staple grain foods and indulgent grain foods, and the majority of studies included in the meta-analyses provided no specific definition of refined grains. Overall, meta-analyses of cohort and case-control studies consistently demonstrate that whole grain intake is associated with lower risk of total and site-specific cancer, and support current dietary recommendations to increase whole grain consumption. By contrast, the relationship between refined grain intake and cancer risk is inconclusive.
Effects of Chlorogenic Acids on Menopausal Symptoms in Healthy Women: A Randomized, Placebo-Controlled, Double-Blind, Parallel-Group Trial
Authors: Enokuchi Yuka , Suzuki Atsushi , Yamaguchi Tohru , Ochiai Ryuji , Terauchi Masakazu , Kataoka Kiyoshi
Published: December 2020

A reduction in estrogen levels in the perimenopausal and postmenopausal periods causes various symptoms in women, such as hot flushes, sweats, depression, anxiety, and insomnia. Chlorogenic acids (CGAs), which are phenolic compounds widely present in plants such as coffee beans, have various physiological functions. However, the effects of CGAs on menopausal symptoms are unknown. To examine the effects of CGAs on menopausal symptoms, especially hot flushes, a randomized, placebo-controlled, double-blind, parallel-group trial was conducted in healthy women. Eighty-two subjects were randomized and assigned to receive CGAs (270 mg) tablets or the placebo for 4 weeks. After 4 weeks of intake, the number of hot flushes, the severity of hot flushes during sleep, and the severity of daytime sweats decreased significantly in the CGA group compared to the placebo group. The modified Kupperman index for menopausal symptoms decreased significantly after 2 weeks in the CGA group compared to the placebo group. Adverse effects caused by CGAs were not observed. The results show that continuous intake of CGAs resulted in improvements in menopausal symptoms, especially hot flushes, in healthy women.
Vitamin C—An Adjunctive Therapy for Respiratory Infection, Sepsis and COVID-19
Authors: Holford Patrick , Carr Anitra C. , Jovic Thomas H. , Ali Stephen R. , Whitaker Iain S. , Marik Paul E. , Smith A. David
Published: December 2020

There are limited proven therapies for COVID-19. Vitamin C’s antioxidant, anti-inflammatory and immunomodulating effects make it a potential therapeutic candidate, both for the prevention and amelioration of COVID-19 infection, and as an adjunctive therapy in the critical care of COVID-19. This literature review focuses on vitamin C deficiency in respiratory infections, including COVID-19, and the mechanisms of action in infectious disease, including support of the stress response, its role in preventing and treating colds and pneumonia, and its role in treating sepsis and COVID-19. The evidence to date indicates that oral vitamin C (2–8 g/day) may reduce the incidence and duration of respiratory infections and intravenous vitamin C (6–24 g/day) has been shown to reduce mortality, intensive care unit (ICU) and hospital stays, and time on mechanical ventilation for severe respiratory infections. Further trials are urgently warranted. Given the favourable safety profile and low cost of vitamin C, and the frequency of vitamin C deficiency in respiratory infections, it may be worthwhile testing patients’ vitamin C status and treating them accordingly with intravenous administration within ICUs and oral administration in hospitalised persons with COVID-19.
Participatory Approaches to Understand Dietary Behaviours of Adolescents in the Secondary School Setting
Authors: Browne Sarah , Barron Carol , Staines Anthony , Sweeney Mary Rose
Published: December 2020

Acknowledgement of wider socio-ecological factors that influence dietary behaviours needs greater consideration in nutrition research with young people. Additionally, children and adolescents have a right to have their voices heard in research that concerns them. The aim of this methods paper is to describe and evaluate participatory methodologies undertaken as part of a dietary behaviour study with adolescents in the school setting in Ireland. Photovoice and peer-led focus groups were the key participatory methodologies, undertaken alongside food diaries and anthropometry. These methodologies were evaluated through discussion with peer researchers, qualitative surveys and in the context of the wider study process and outcomes. Peer researchers reported learning new skills including research, facilitation, listening and social skills and many felt they gained confidence, as well as an awareness about healthy and unhealthy practices at school. The findings were found to be authentic according to students, except for two limitations. Students believed body image was not adequately represented in the findings, and alternative focus group compositions could have influenced discussion content. Youth participants were afforded genuine opportunities to have their voices heard as part of a diet and nutrition research and the methodologies were acceptable and enjoyable. They demonstrated agency in valuable contributions at project design, data collection, analysis and interpretation stages of the research process. Furthermore, the participatory methodologies complemented quantitative data by providing environmental, behavioural, and socio-cultural insights into food choice in the school setting.
From Ethnomedicine to Plant Biotechnology and Machine Learning: The Valorization of the Medicinal Plant Bryophyllum sp.
Authors: García-Pérez Pascual , Lozano-Milo Eva , Landin Mariana , Gallego Pedro P.
Published: December 2020

The subgenus Bryophyllum includes about 25 plant species native to Madagascar, and is widely used in traditional medicine worldwide. Different formulations from Bryophyllum have been employed for the treatment of several ailments, including infections, gynecological disorders, and chronic diseases, such as diabetes, neurological and neoplastic diseases. Two major families of secondary metabolites have been reported as responsible for these bioactivities: phenolic compounds and bufadienolides. These compounds are found in limited amounts in plants because they are biosynthesized in response to different biotic and abiotic stresses. Therefore, novel approaches should be undertaken with the aim of achieving the phytochemical valorization of Bryophyllum sp., allowing a sustainable production that prevents from a massive exploitation of wild plant resources. This review focuses on the study of phytoconstituents reported on Bryophyllum sp.; the application of plant tissue culture methodology as a reliable tool for the valorization of bioactive compounds; and the application of machine learning technology to model and optimize the full phytochemical potential of Bryophyllum sp. As a result, Bryophyllum species can be considered as a promising source of plant bioactive compounds, with enormous antioxidant and anticancer potential, which could be used for their large-scale biotechnological exploitation in cosmetic, food, and pharmaceutical industries.
Enhancing the Low Oral Bioavailability of Sulpiride via Fast Orally Disintegrating Tablets: Formulation, Optimization and In Vivo Characterization
Authors: M. Tawfeek Hesham , Hassan Yasser A. , Aldawsari Mohammed F. , H. Fayed Mohamed
Published: December 2020

Sulpiride (SUL) is a dopamine D2-receptor antagonist used for management of GIT disturbance and it has anti-psychotic activities based on the administered dose. SUL undergoes P-glycoprotein efflux, which lead to poor bioavailability and erratic absorption. Therefore, the objective of this research was an attempt to enhance the oral bioavailability of SUL via formulation of fast disintegrating tablets (SUL-FDTs) with a rapid onset of action. A 32 full-factorial design was performed for optimization of SUL-FDTs using desirability function. The concentration of superdisintegrant (X1) and Prosolv® (X2) were selected as independent formulation variables for the preparation and optimization of SUL-FDTs using direct compression technique. The prepared SUL-FDTs were investigated regarding their mechanical strength, disintegration time, drug release and in vivo pharmacokinetic analysis in rabbits. The optimized formulation has hardness of 4.58 ± 0.52 KP, friability of 0.73 ± 0.158%, disintegration time of 37.5 ± 1.87 s and drug release of 100.51 ± 1.34% after 30 min. In addition, the optimized SUL-FDTs showed a significant (p < 0.01) increase in Cmax and AUC(0–∞) and a relative bioavailability of about 9.3 fold compared to the commercial product. It could be concluded that SUL-FDTs are a promising formulation for enhancing the oral bioavailability of SUL concomitant with a fast action.
Avalanche Photodetector Based on InAs/InSb Superlattice
Authors: Dehzangi Arash , Li Jiakai , Gautam Lakshay , Razeghi Manijeh
Published: December 2020

This work demonstrates a mid-wavelength infrared InAs/InSb superlattice avalanche photodiode (APD). The superlattice APD structure was grown by molecular beam epitaxy on GaSb substrate. The device exhibits a 100 % cut-off wavelength of 4.6 µm at 150 K and 4.30 µm at 77 K. At 150 and 77 K, the device responsivity reaches peak values of 2.49 and 2.32 A/W at 3.75 µm under −1.0 V applied bias, respectively. The device reveals an electron dominated avalanching mechanism with a gain value of 6 at 150 K and 7.4 at 77 K which was observed under −6.5 V bias voltage. The gain value was measured at different temperatures and different diode sizes. The electron and hole impact ionization coefficients were calculated and compared to give a better prospect of the performance of the device.
Secularization, Religious Denominations, and Differences in Regional Characteristics: The State of Research and a Regional Statistical Investigation for Germany
Authors: Diller Christian , Gareis Philipp
Published: December 2020

The paper pursues the question of the relationship between secularization, religious denominations, and regional characteristics. A literature review leads to the formation of six hypotheses. The analysis of regional statistics for Germany shows clear regional differences in the distribution of the denominational affiliation as well as the secularization of the population. Traditional differences between the federal states and their sub-regions are still recognizable. In particular, there is an obvious difference in secularization between the East German and West German states in relation to the significance of the two large Christian denominations. These differences between the paths of regional development and degree of secularization are so large that most of the hypothesis testing on the association between religious affiliation and demographic and socio-economic variables resulted in different findings for the two areas. Further research is required to pursue more regional differentiation and to include non-Christian faiths in the investigations.
Popular Piety and Devotion to Parish Patrons in Poland and Spain, 1948–98
Authors: Roszak Piotr , Tykarski Sławomir
Published: December 2020

This paper will show the dynamics of change in the celebration of the parish patron’s day at the turn of several decades (before and after the Second Vatican Council) at a Marian shrine in Poland and the cult of Cross from Monjardin in Spain. It will refer to various forms of ritual which are manifestations of popular piety: cultural expressions, services, prayers and songs which form part of the veneration of Our Lady of Sorrows, Chełmno and the Cross in Villamayor de Monjardin. The article will also examine the different ways in which these feasts were celebrated during the period and the impact they had on the religious life of pilgrims. The study will be based on written sources: memories, diaries, newspaper clippings, and historical studies which are instrumental in demonstrating the transformation of how the parish patron’s day was celebrated over time.
Bootstrapping Artificial Evolution to Design Robots for Autonomous Fabrication
Authors: Buchanan Edgar , Le Goff Léni K. , Li Wei , Hart Emma , Eiben Agoston E. , De Carlo Matteo , Winfield Alan F. , Hale Matthew F. , Woolley Robert , Angus Mike , Timmis Jon , Tyrrell Andy M.
Published: December 2020

A long-term vision of evolutionary robotics is a technology enabling the evolution of entire autonomous robotic ecosystems that live and work for long periods in challenging and dynamic environments without the need for direct human oversight. Evolutionary robotics has been widely used due to its capability of creating unique robot designs in simulation. Recent work has shown that it is possible to autonomously construct evolved designs in the physical domain; however, this brings new challenges: the autonomous manufacture and assembly process introduces new constraints that are not apparent in simulation. To tackle this, we introduce a new method for producing a repertoire of diverse but manufacturable robots. This repertoire is used to seed an evolutionary loop that subsequently evolves robot designs and controllers capable of solving a maze-navigation task. We show that compared to random initialisation, seeding with a diverse and manufacturable population speeds up convergence and on some tasks, increases performance, while maintaining manufacturability.
Detection and Characterization of Physical Activity and Psychological Stress from Wristband Data
Authors: Sevil Mert , Rashid Mudassir , Askari Mohammad Reza , Maloney Zacharie , Hajizadeh Iman , Cinar Ali
Published: December 2020

Wearable devices continuously measure multiple physiological variables to inform users of health and behavior indicators. The computed health indicators must rely on informative signals obtained by processing the raw physiological variables with powerful noise- and artifacts-filtering algorithms. In this study, we aimed to elucidate the effects of signal processing techniques on the accuracy of detecting and discriminating physical activity (PA) and acute psychological stress (APS) using physiological measurements (blood volume pulse, heart rate, skin temperature, galvanic skin response, and accelerometer) collected from a wristband. Data from 207 experiments involving 24 subjects were used to develop signal processing, feature extraction, and machine learning (ML) algorithms that can detect and discriminate PA and APS when they occur individually or concurrently, classify different types of PA and APS, and estimate energy expenditure (EE). Training data were used to generate feature variables from the physiological variables and develop ML models (naïve Bayes, decision tree, k-nearest neighbor, linear discriminant, ensemble learning, and support vector machine). Results from an independent labeled testing data set demonstrate that PA was detected and classified with an accuracy of 99.3%, and APS was detected and classified with an accuracy of 92.7%, whereas the simultaneous occurrences of both PA and APS were detected and classified with an accuracy of 89.9% (relative to actual class labels), and EE was estimated with a low mean absolute error of 0.02 metabolic equivalent of task (MET).The data filtering and adaptive noise cancellation techniques used to mitigate the effects of noise and artifacts on the classification results increased the detection and discrimination accuracy by 0.7% and 3.0% for PA and APS, respectively, and by 18% for EE estimation. The results demonstrate the physiological measurements from wristband devices are susceptible to noise and artifacts, and elucidate the effects of signal processing and feature extraction on the accuracy of detection, classification, and estimation of PA and APS.
Present Status of Nuclear Shell-Model Calculations of 0νββ Decay Matrix Elements
Authors: Coraggio Luigi , Itaco Nunzio , De Gregorio Giovanni , Gargano Angela , Mancino Riccardo , Pastore Saori
Published: December 2020

Neutrinoless double beta (0νββ) decay searches are currently among the major foci of experimental physics. The observation of such a decay will have important implications in our understanding of the intrinsic nature of neutrinos and shed light on the limitations of the Standard Model. The rate of this process depends on both the unknown neutrino effective mass and the nuclear matrix element (M0ν) associated with the given 0νββ transition. The latter can only be provided by theoretical calculations, hence the need of accurate theoretical predictions of M0ν for the success of the experimental programs. This need drives the theoretical nuclear physics community to provide the most reliable calculations of M0ν. Among the various computational models adopted to solve the many-body nuclear problem, the shell model is widely considered as the basic framework of the microscopic description of the nucleus. Here, we review the most recent and advanced shell-model calculations of M0ν considering the light-neutrino-exchange channel for nuclei of experimental interest. We report the sensitivity of the theoretical calculations with respect to variations in the model spaces and the shell-model nuclear Hamiltonians.