bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation of neonatal mortality data completeness and accuracy in Ghana
Authors: Dadzie Dora , Boadu Richard Okyere , Engmann Cyril Mark , Twum-Danso Nana Amma Yeboaa
Published: March 2021

Background

Cause-specific mortality data are required to set interventions to reduce neonatal mortality. However, in many developing countries, these data are either lacking or of low quality. We assessed the completeness and accuracy of cause of death (COD) data for neonates in Ghana to assess their usability for monitoring the effectiveness of health system interventions aimed at improving neonatal survival.

Methods

A lot quality assurance sampling survey was conducted in 20 hospitals in the public sector across four regions of Ghana. Institutional neonatal deaths (IND) occurring from 2014 through 2017 were divided into lots, defined as neonatal deaths occurring in a selected facility in a calendar year. A total of 52 eligible lots were selected: 10 from Ashanti region, and 14 each from Brong Ahafo, Eastern and Volta region. Nine lots were from 2014, 11 from 2015 and 16 each were from 2016 and 2017. The cause of death (COD) of 20 IND per lot were abstracted from admission and discharge (A&D) registers and validated against the COD recorded in death certificates, clinician’s notes or neonatal death audit reports for consistency. With the error threshold set at 5%, ≥ 17 correctly matched diagnoses in a sample of 20 deaths would make the lot accurate for COD diagnosis. Completeness of COD data was measured by calculating the proportion of IND that had death certificates completed.

Results

Nineteen out of 52 eligible (36.5%) lots had accurate COD diagnoses recorded in their A&D registers. The regional distribution of lots with accurate COD data is as follows: Ashanti (4, 21.2%), Brong Ahafo (7, 36.8%), Eastern (4, 21.1%) and Volta (4, 21.1%). Majority (9, 47.4%) of lots with accurate data were from 2016, followed by 2015 and 2017 with four (21.1%) lots. Two (10.5%) lots had accurate COD data in 2014. Only 22% (239/1040) of sampled IND had completed death certificates.

Conclusion

Death certificates were not reliably completed for IND in a sample of health facilities in Ghana from 2014 through 2017. The accuracy of cause-specific mortality data recorded in A&D registers was also below the desired target. Thus, recorded IND data in public sector health facilities in Ghana are not valid enough for decision-making or planning. Periodic data quality assessments can determine the magnitude of the data quality concerns and guide site-specific improvements in mortality data management.
Neural representation of words within phrases: Temporal evolution of color-adjectives and object-nouns during simple composition
Authors: Honari-Jahromi Maryam , Chouinard Brea , Blanco-Elorrieta Esti , Pylkkänen Liina , Fyshe Alona
Published: March 2021

In language, stored semantic representations of lexical items combine into an infinitude of complex expressions. While the neuroscience of composition has begun to mature, we do not yet understand how the stored representations evolve and morph during composition. New decoding techniques allow us to crack open this very hard question: we can train a model to recognize a representation in one context or time-point and assess its accuracy in another. We combined the decoding approach with magnetoencephalography recorded during a picture naming task to investigate the temporal evolution of noun and adjective representations during speech planning. We tracked semantic representations as they combined into simple two-word phrases, using single words and two-word lists as non-combinatory controls. We found that nouns were generally more decodable than adjectives, suggesting that noun representations were stronger and/or more consistent across trials than those of adjectives. When training and testing across contexts and times, the representations of isolated nouns were recoverable when those nouns were embedded in phrases, but not so if they were embedded in lists. Adjective representations did not show a similar consistency across isolated and phrasal contexts. Noun representations in phrases also sustained over time in a way that was not observed for any other pairing of word class and context. These findings offer a new window into the temporal evolution and context sensitivity of word representations during composition, revealing a clear asymmetry between adjectives and nouns. The impact of phrasal contexts on the decodability of nouns may be due to the nouns’ status as head of phrase—an intriguing hypothesis for future research.
Intense pulsed light plus meibomian gland expression versus intense pulsed light alone for meibomian gland dysfunction: A randomized crossover study
Authors: Shin Kyoung Yoon , Lim Dong Hui , Moon Chan Hee , Kim Byung Jin , Chung Tae-Young
Published: March 2021

Purpose

To investigate the comparative efficacy of intense pulsed light (IPL) therapy alone with that of IPL plus meibomian gland expression (MGX) for meibomian gland dysfunction (MGD).

Methods

This is a prospective randomized crossover clinical trial. Sixty patients were enrolled and randomly assigned to two groups. All of patients underwent four treatment sessions in total, which were two weeks apart. Group 1 underwent two sessions of IPL therapy with MGX, as well as two sessions of IPL alone. Group 2 received two sessions of IPL therapy alone, and two sessions of IPL therapy with MGX. The following parameters were measured at baseline (BL), 2 weeks after the second treatment session (FU1), and 2 weeks after the fourth treatment session (FU2): tearfilm break-up time (BUT), Oxford grade for corneal staining, meibomian gland expressibility (MGE), meibum quality (MQ), and ocular surface disease index (OSDI). The separate effect of MGX on improvement of MGD parameters was evaluated using generalized estimating equation (GEE).

Results

The mean age of the participants was 57.52 ± 10.50 years. The BUT, Oxford grade, MGE, MQ, and OSDI of both groups improved significantly (from baseline) by the end of four treatment sessions (FU2 compared to BL; all p-values <0.05). The MGE and MQ significantly improved after the first and second treatment sessions (FU1 compare to BL; all p-values < 0.001). However, the improvement was not statistically significant after the third and fourth treatment sessions (FU2 compared to FU1; p-value of 0.388 for MGE and 0.645 for MQ in group 1, 0.333 for MGE and 0.333 for MQ in group 2). The IPL plus MGX therapy produced greater improvements in the BUT scores than did IPL therapy alone (p = 0.003 by GEE). In contrast, the Oxford grade, MGE, MQ, and OSDI were not influenced by the addition of MGX to IPL (p = 0.642, 0.663, 0.731, and 0.840, respectively by GEE).

Conclusion

IPL therapy effectively improves the subjective symptoms and objective ocular findings of MGD. MGX enhanced the improvement of BUT driven by IPL therapy. The meibomian gland function (MGE and MQ) recovers faster in response to IPL therapy than did the other parameters.
Prediction of femoral osteoporosis using machine-learning analysis with radiomics features and abdomen-pelvic CT: A retrospective single center preliminary study
Authors: Lim Hyun Kyung , Ha Hong Il , Park Sun-Young , Han Junhee
Published: March 2021

Background

Osteoporosis has increased and developed into a serious public health concern worldwide. Despite the high prevalence, osteoporosis is silent before major fragility fracture and the osteoporosis screening rate is low. Abdomen-pelvic CT (APCT) is one of the most widely conducted medical tests. Artificial intelligence and radiomics analysis have recently been spotlighted. This is the first study to evaluate the prediction performance of femoral osteoporosis using machine-learning analysis with radiomics features and APCT.

Materials and methods

500 patients (M: F = 70:430; mean age, 66.5 ± 11.8yrs; range, 50–96 years) underwent both dual-energy X-ray absorptiometry and APCT within 1 month. The volume of interest of the left proximal femur was extracted and 41 radiomics features were calculated using 3D volume of interest analysis. Top 10 importance radiomic features were selected by the intraclass correlation coefficient and random forest feature selection. Study cohort was randomly divided into 70% of the samples as the training cohort and the remaining 30% of the sample as the validation cohort. Prediction performance of machine-learning analysis was calculated using diagnostic test and comparison of area under the curve (AUC) of receiver operating characteristic curve analysis was performed between training and validation cohorts.

Results

The osteoporosis prevalence of this study cohort was 20.8%. The prediction performance of the machine-learning analysis to diagnose osteoporosis in the training and validation cohorts were as follows; accuracy, 92.9% vs. 92.7%; sensitivity, 86.6% vs. 80.0%; specificity, 94.5% vs. 95.8%; positive predictive value, 78.4% vs. 82.8%; and negative predictive value, 96.7% vs. 95.0%. The AUC to predict osteoporosis in the training and validation cohorts were 95.9% [95% confidence interval (CI), 93.7%-98.1%] and 96.0% [95% CI, 93.2%-98.8%], respectively, without significant differences (P = 0.962).

Conclusion

Prediction performance of femoral osteoporosis using machine-learning analysis with radiomics features and APCT showed high validity with more than 93% accuracy, specificity, and negative predictive value.
Level of serum soluble lumican and risks of perioperative complications in patients receiving aortic surgery
Authors: Hsu Ming-En , Cheng Yu-Ting , Chang Chih-Hsiang , Chan Yi‐Hsin , Wu Victor Chien-Chia , Hung Kuo-Chun , Lin Chia-Pin , Liu Kuo-Sheng , Chu Pao-Hsien , Chen Shao-Wei
Published: March 2021

Objective

Several serum biomarkers have been investigated for their potential as diagnostic tools in aortic disease; however, no study has investigated the association between serum biomarkers and outcomes after aortic surgery. This study explored the predictive ability of serum soluble lumican in postoperative outcomes after aortic surgery.

Methods

In total, 58 patients receiving aortic surgery for aortic dissection or aneurysm at Linkou Chang Gung Memorial Hospital in Taiwan in December 2011–September 2018 were enrolled. Blood samples were collected immediately upon patients’ arrival in the intensive care unit after aortic surgery. The diagnostic properties of soluble lumican levels were assessed by performing receiver operating characteristic (ROC) curve analysis. The confidence interval (CI) of the area under the ROC curve (AUC) was measured using DeLong’s nonparametric method and the optimal cutoff was determined using the Youden index.

Results

The serum soluble lumican level distinguished prolonged ventilation (AUC, 73.5%; 95% CI, 57.7%–89.3%) and hospital stay for >30 days (AUC, 78.2%; 95% CI, 61.6%–94.7%). The optimal cutoffs of prolonged ventilation and hospital stay for >30 days were 1.547 and 5.992 ng/mL, respectively. The sensitivity and specificity were respectively 100% (95% CI, 71.5%–100%) and 40.4% (95% CI, 26.4%–55.7%) for prolonged ventilation and 58% (95% 27.7%–84.8%) and 91.3% (95% CI, 79.2%–97.6%) for hospital stay for >30 days.

Conclusions

The serum soluble lumican level can be a potential prognostic factor for predicting poor postoperative outcomes after aortic surgery. However, more studies are warranted in the future.
Mast cells contribute to alveolar bone loss in Spontaneously Hypertensive Rats with periodontal disease regulating cytokines production
Authors: Brito Victor Gustavo Balera , Patrocinio Mariana Sousa , Sousa Maria Carolina Linjardi , Barreto Ayná Emanuelli Alves , Frasnelli Sabrina Cruz Tfaile , Lara Vanessa Soares , Santos Carlos Ferreira , Oliveira Sandra Helena Penha
Published: March 2021

Mast cells (MCs) play a pivotal role in inflammatory responses and had been studied in inflammatory bone disorders, however, their role in alveolar bone loss induced by periodontal disease (PD) is not yet fully understood. We, therefore, aimed to evaluate the effects of MCs depletion in the PD-induced alveolar bone loss in Wistar (W) and Spontaneously Hypertensive Rats (SHRs). PD was induced by ligating the lower first molars with silk thread one day after the MCs depletion, by the pre-treatment with compound 48/80 for 4 days. After 15 days of PD induction, the hemi-mandibles were surgically collected for qRT-PCR, histological analyses, immunostaining, and ELISA. Systolic blood pressure (SBP) was verified by tail plethysmography to confirm the hypertensive status, and SHR presented SBP >150 mmHg, and previous MC depletion alone or associated with PD did not alter this parameter. SHRs showed a more severe alveolar bone loss compared to W, and MC depletion significantly inhibited this response in both strains, with a more significant response in SHRs. MCs were less abundant in 48/80+PD groups, thus validating the previous MCs depletion in our model. PD increased the number of MC in the gingival tissue of SHR. Cytokine production (TNF-α, IL-6, IL-1β, and CXCL3) was constitutively higher in SHR and increased further after PD, which was also significantly reduced in the MCs-depleted animals. PD led to an increased expression of Opn, Rankl, Rank, Vtn, Itga5, Itgb5, Trap, and Ctsk in the mandible of W and SHRs, which was reversed in MCs-depleted animals. These results suggest that MCs significantly contributes to the PD-induced alveolar bone resorption, especially in the SHR, which is associated with a more severe PD progression compared to Wistar, partly explained by these cells contribution to the inflammatory status and mediator production, stimulating osteoclast-related response markers, which were reduced after MC depletion in our experimental model.
The effect of light quality on plant physiology, photosynthetic, and stress response in Arabidopsis thaliana leaves
Authors: Yavari Nafiseh , Tripathi Rajiv , Wu Bo-Sen , MacPherson Sarah , Singh Jaswinder , Lefsrud Mark
Published: March 2021

The impacts of wavelengths in 500–600 nm on plant response and their underlying mechanisms remain elusive and required further investigation. Here, we investigated the effect of light quality on leaf area growth, biomass, pigments content, and net photosynthetic rate (Pn) across three Arabidopsis thaliana accessions, along with changes in transcription, photosynthates content, and antioxidative enzyme activity. Eleven-leaves plants were treated with BL; 450 nm, AL; 595 nm, RL; 650 nm, and FL; 400–700 nm as control. RL significantly increased leaf area growth, biomass, and promoted Pn. BL increased leaf area growth, carotenoid and anthocyanin content. AL significantly reduced leaf area growth and biomass, while Pn remained unaffected. Petiole elongation was further observed across accessions under AL. To explore the underlying mechanisms under AL, expression of key marker genes involved in light-responsive photosynthetic reaction, enzymatic activity of antioxidants, and content of photosynthates were monitored in Col-0 under AL, RL (as contrast), and FL (as control). AL induced transcription of GSH2 and PSBA, while downregulated NPQ1 and FNR2. Photosynthates, including proteins and starches, showed lower content under AL. SOD and APX showed enhanced enzymatic activity under AL. These results provide insight into physiological and photosynthetic responses to light quality, in addition to identifying putative protective-mechanisms that may be induced to cope with lighting-stress in order to enhance plant stress tolerance.
High-intensity, whole-body exercise improves blood pressure control in individuals with spinal cord injury: A prospective randomized controlled trial
Authors: Solinsky Ryan , Draghici Adina , Hamner Jason W. , Goldstein Rich , Taylor J. Andrew
Published: March 2021

Blood pressure regulation following spinal cord injury (SCI) is often compromised due to impaired vascular sympathetic control, leading to increased reliance on cardiovagal baroreflex sensitivity to maintain pressure. Whole-body exercise improves cardiovagal baroreflex sensitivity in uninjured individuals, though has not been explored in those with SCI. Our objective was to determine changes in cardiovagal baroreflex sensitivity following 6 months of high-intensity, whole-body exercise in individuals with SCI compared to lower-intensity, arms only exercise, or waitlist. This randomized controlled trial recruited individuals with SCI aged 18–40 years old. Sixty-one individuals were randomized, with 38 completing at least one cardiovagal baroreflex sensitivity assessment. Whole-body exercise was performed with hybrid functional electrical stimulation rowing prescribed as two to three times per week, for 30–60 minutes with a target heart rate of >75% of maximum. The arms only exercise group performed upper body rowing exercise with the same prescription as whole-body exercise. Waitlist controls were not enrolled in any explicit training regimen. After 6 months, those in arms only exercise or waitlist crossed over to whole-body exercise. Cardiovagal baroreflex sensitivity was assessed via the neck suction technique at baseline and at three-month intervals thereafter. Intention to treat analysis with a structured equation model demonstrated no significant effect of waitlist control or arms only exercise on cardiovagal baroreflex sensitivity. Whole-body exercise significantly improved cardiovagal baroreflex sensitivity at 6 months for those initially randomized (p = 0.03), as well as those who crossed over from arms only exercise or waitlist control (p = 0.03 for each). However, amount of exercise performed and aerobic gains (VO2max) each poorly correlated with increases in cardiovagal baroreflex sensitivity (R2<0.15). In post-hoc analyses, individuals with paraplegia made significantly greater gains in baroreflex sensitivity compared to those with tetraplegia (p = 0.02), though gains within this group were again poorly correlated to gains in aerobic capacity. Clinicaltrials.gov number NCT02139436.
Multiple-to-multiple path analysis model
Authors: Du Yujie , Du Junli , Liu Xi , Yuan Zhifa
Published: March 2021

One-to-multiple path analysis model describes the regulation mechanism of multiple independent variables to one dependent variable by dividing the correlation coefficient and the determination coefficient. How to analyse more complex regulation mechanisms of multiple independent variables to multiple dependent variables? Similarly, according to multiple-to-multiple linear regression analysis, multiple-to-multiple path analysis model was proposed in this paper and it demonstrated more complex regulation mechanisms among multiple independent variables and multiple dependent variables by dividing the generalized determination coefficient. Differently, three other types of paths were generated in multiple-to-multiple path analysis model in that the correlation among multiple dependent variables was considered. Then, the decision coefficient of each independent variable was constructed for dependent variables system, and its hypothesis testing statistics were given. Finally, the research example of the wheat breeding rules in arid area demonstrated that the multiple-to-multiple path analysis considering more correlation information can get better results.
Isoalantolactone inhibits pancreatic cancer proliferation by regulation of PI3K and Wnt signal pathway
Authors: Zhang Chaoxiong , Huang Lei , Xiong Jingyuan , Xie Linshen , Ying Shi , Jia You , Yao Yuqin , Song Xuejiao , Zeng Zhenguo , Yuan Jialing
Published: March 2021

Background/aims

Isoalantolactone (IATL) is one of multiple isomeric sesquiterpene lactones and is isolated from inula helenium. IATL has multiple functions such as antibacterial, antihelminthic and antiproliferative activities. IATL also inhibits pancreatic cancer proliferation and induces apoptosis by increasing ROS production. However, the detailed mechanism of IATL-mediated pancreatic cancer apoptosis remains largely unknown.

Methods

In current study, pancreatic carcinoma cell lines (PANC-1, AsPC-1, BxPC-3) and a mouse xenograft model were used to determine the mechanism of IATL-mediated toxic effects.

Results

IATL (20μM) inhibited pancreatic adenocarcinoma cell lines proliferation in a time-dependent way; while scratch assay showed that IATL significantly inhibited PANC-1 scratch closure (P<0.05); Invasion assays indicated that IATL significantly attenuated pancreatic adenocarcinoma cell lines invasion on matrigel. Signal analysis showed that IATL inhibited pancreatic adenocarcinoma cell proliferation by blocking EGF-PI3K-Skp2-Akt signal axis. Moreover, IATL induced pancreatic adenocarcinoma cell apoptosis by increasing cytosolic Caspase3 and Box expression. This apoptosis was mediated by inhibition of canonical wnt signal pathway. Finally, xenograft studies showed that IATL also significantly inhibited pancreatic adenocarcinoma cell proliferation and induced pancreatic adenocarcinoma cell apoptosis in vivo.

Conclusions

IATL inhibits pancreatic cancer proliferation and induces apoptosis on cellular and in vivo models. Signal pathway studies reveal that EGF-PI3K-Skp2-Akt signal axis and canonical wnt pathway are involved in IATL-mediated cellular proliferation inhibition and apoptosis. These studies indicate that IATL may provide a future potential therapy for pancreatic cancer.
Visual attention towards food during unplanned purchases – A pilot study using mobile eye tracking technology
Authors: Hummel Gerrit , Maier Saskia , Baumgarten Maren , Eder Cora , Strubich Patrick Thomas , Stroebele-Benschop Nanette
Published: March 2021

This pilot study aims to investigate the relationships between consumers’ weight status, energy density of food and visual attention towards food during unplanned purchase behavior in a real-world environment. After more than a decade of intensive experimental eye tracking research on food perception, this pilot study attempts to link experimental and field research in this area. Shopping trips of participants with different weight status were recorded with mobile eye tracking devices and their unplanned purchase behavior was identified and analyzed. Different eye movement measurements for initial orientation and maintained attention were analyzed. Differences in visual attention caused by energy density of food were found. There was a tendency across all participants to look at low energy density food longer and more often.
Depression and frailty in older adults: A population-based cohort study
Authors: Da Mata Fabiana Araújo Figueiredo , Miranda Forte Gomes Marilia , Lício Ferreira Santos Jair , Aparecida de Oliveira Duarte Yeda , Gomes Pereira Mauricio
Published: March 2021

Background

Studies have shown an association between depression and frailty, even though the literature has not reached a consensus regarding how these syndromes interact. Although prospective cohort studies on this topic are still scarce, they could contribute to understanding this relationship. We aimed to observe whether depressive symptoms are risk factors for the onset of frailty among older adults living in São Paulo, Brazil.

Methods

Prospective cohort study using the “Health, Well-being and Aging” (SABE) Study databases of 2006 and 2010. The sample was representative of the community-dwelling older adults living in São Paulo, and it is composed of non-frail men and women aged 60 years and older without cognitive decline. We calculated the frailty incidence rate between older adults with and without depressive symptoms and calculated the incidence rate ratio. Multiple analysis was carried out through Poisson regression with robust variance estimation.

Results

The initial sample (n = 1,109) presented a mean age of 72 years (from 60 to 96) and 61.1% were women. The final sample was composed of 830 individuals, and the mean follow-up time in the study was 3.8 years. After adjusting the model, depressive symptoms did not predict the onset of frailty at follow-up.

Conclusion

Depressive symptoms were not shown to be a risk factor for frailty among older adults living in São Paulo in this study.
Microscopic inflammation in ileocecal specimen does not correspond to a higher anastomotic leakage rate after ileocecal resection in Crohn’s disease
Authors: Schineis Christian , Ullrich Andrea , Lehmann Kai S. , Holmer Christoph , Lauscher Johannes C. , Weixler Benjamin , Kreis Martin E. , Seifarth Claudia
Published: March 2021

Background

Patients with Crohn’s disease suffer from a higher rate of anastomotic leakages after ileocecal resection than patients without Crohn’s disease. Our hypothesis was that microscopic inflammation at the resection margins of ileocecal resections in Crohn’s disease increases the rate of anastomotic leakages.

Patients and methods

In a retrospective cohort study, 130 patients with Crohn’s disease that underwent ileocecal resection between 2015 and 2019, were analyzed. Anastomotic leakage was the primary outcome parameter. Inflammation at the resection margin was characterized as “inflammation at proximal resection margin”, “inflammation at distal resection margin” or “inflammation at both ends”.

Results

46 patients (35.4%) showed microscopic inflammation at the resection margins. 17 patients (13.1%) developed anastomotic leakage. No difference in the rate of anastomotic leakages was found for proximally affected resection margins (no anastomotic leakage vs. anastomotic leakage: 20.3 vs. 35.3%, p = 0.17), distally affected resection margins (2.7 vs. 5.9%, p = 0.47) or inflammation at both ends (9.7 vs. 11.8%, p = 0.80). No effect on the anastomotic leakage rate was found for preoperative hemoglobin concentration (no anastomotic leakage vs. anastomotic leakage: 12.3 vs. 13.5 g/dl, p = 0.26), perioperative immunosuppressive medication (62.8 vs. 52.9%, p = 0.30), BMI (21.8 vs. 22.4 m2/kg, p = 0.82), emergency operation (21.2 vs. 11.8%, p = 0.29), laparoscopic vs. open procedure (p = 0.58), diverting ileostomy (31.9 vs. 57.1%, p = 0.35) or the level of surgical training (staff surgeon: 80.5 vs. 76.5%, p = 0.45).

Conclusion

Microscopic inflammation at the resection margins after ileocecal resection in Crohn’s disease is common. Histologically inflamed resection margins do not appear to affect the rate of anastomotic leakages. Our data suggest that there is no need for extensive resections or frozen section to achieve microscopically inflammation-free resection margins.
Genomic characterization and evolution of SARS-CoV-2 of a Canadian population
Authors: Zhang Manna , Li Lin , Luo Ma , Liang Binhua
Published: March 2021

COVID-19 has greatly affected public health and world economy. In this study, we analyzed 129 full-length genomes of SARS-CoV-2 viruses of a Canadian population during early phase of the pandemic. Phylogenetic analysis revealed three major paths of transmission of SARS-CoV-2 viruses into Canada. Twenty-one substitutions that have frequencies greater than 3% of viral population were identified. Analysis of these substitutions indicated that P1427I (ORF1b), Y1464C (ORF1b), and Q57H (ORF3a) might affect functions of the corresponding SARS-CoV-2 encoded proteins. Additionally, we found the evidence of positive selection on the ORF3a and codon 614 of Spike protein, suggesting the viral components responsible for host entry and activation of inflammation response were targeted by host immune responses. The study showed genomic variation and evolution of SARS-CoV-2 in a Canadian population. These information may help develop preventive strategies and be used for further study of SARS-CoV-2 pathogenesis and therapeutics development.
Effects of foliar fungicide on yield, micronutrients, and cadmium in grains from historical and modern hard winter wheat genotypes
Authors: Motta-Romero Hollman , Niyongira Ferdinand , Boehm Jeffrey D. , Rose Devin J.
Published: March 2021

Plant breeding and disease management practices have increased the grain yield of hard winter wheat (Triticum aestivum L.) adapted to the Great Plains of the United States during the last century. However, the effect of genetic gains for seed yield and the application of fungicide on the micronutrient and cadmium (Cd) concentration in wheat grains is still unclear. The objectives of this study were to evaluate the effects of fungicide application on the productivity and nutritional quality of wheat cultivars representing 80 years of plant breeding efforts. Field experiments were conducted over two crop years (2017 and 2018) with eighteen hard winter wheat genotypes released between 1933 and 2013 in the presence or absence of fungicide application. For each growing season, the treatments were arranged in a split-plot design with the fungicide levels (treated and untreated) as the whole plot treatments and the genotypes as split-plot treatments in triplicate. The effects on seed yield, grain protein concentration (GPC), micronutrients, phytic acid, and Cd in grains were measured. While the yield of wheat was found to increase at annualized rates of 26.5 and 13.0 kg ha-1 yr-1 in the presence and absence of fungicide (P < 0.001), respectively, GPC (-190 and -180 mg kg-1 yr-1, P < 0.001), Fe (-35.0 and -44.0 μg kg-1 yr-1, P < 0.05), and Zn (-68.0 and -57.0 μg kg-1 yr-1, P < 0.01) significantly decreased during the period studied. In contrast to the other mineral elements, grain Cd significantly increased over time (0.4 μg kg-1 yr-1, P < 0.01) in the absence of fungicide. The results from this study are of great concern, as many mineral elements essential for human nutrition have decreased over time while the toxic heavy metal, Cd, has increased, indicating modern wheats are becoming a better vector of dietary Cd.
Assessment of root phenotypes in mungbean mini-core collection (MMC) from the World Vegetable Center (AVRDC) Taiwan
Authors: Aski Muraleedhar S. , Rai Neha , Reddy Venkata Ravi Prakash , Gayacharan  , Dikshit Harsh Kumar , Mishra Gyan Prakash , Singh Dharmendra , Kumar Arun , Pandey Renu , Singh Madan Pal , Pratap Aditya , Nair Ramakrishnan M. , Schafleitner Roland
Published: March 2021

Mungbean (Vigna radiataL.) is an important food grain legume, but its production capacity is threatened by global warming, which can intensify plant stress and limit future production. Identifying new variation of key root traits in mungbean will provide the basis for breeding lines with effective root characteristics for improved water uptake to mitigate heat and drought stress. The AVRDC mungbean mini core collection consisting of 296 genotypes was screened under modified semi-hydroponic screening conditions to determine the variation for fourteen root-related traits. The AVRDC mungbean mini core collection displayed wide variations for the primary root length, total surface area, and total root length, and based on agglomerative hierarchical clustering eight homogeneous groups displaying different root traits could be identified. Germplasm with potentially favorable root traits has been identified for further studies to identify the donor genotypes for breeding cultivars with enhanced adaptation to water-deficit stress and other stress conditions.
Risk factors affecting intimate partner violence occurrence in South Korea: Findings from the 2016 Domestic Violence Survey
Authors: Han Young-Ran , Choi Hye Young
Published: March 2021

This study aimed to identify factors affecting the occurrence of intimate partner violence (IPV) in Korean adults aged 19 years and older. Specifically, we identified the factors in women’s victimization in and men’s perpetration of IPV. This study adopted a cross-sectional and correlational design in conducting secondary data analysis of the 2016 Domestic Violence Survey in Korea. Men (N = 1,272) and women (N = 2,689) with partner were included in the analysis. The ecological model was used as a conceptual framework. Multiple logistic regression analyses were conducted to identify factors affecting women’s victimization in and men’s perpetration of IPV. The results showed that the prevalence of IPV against female partner was 12.1%. IPV occurrence was higher among women (Odds ratios (OR) = 2.92, Confidence intervals (CI): 1.84–4.63) and men (OR = 2.64, CI: 1.62–4.32) who experienced witnessing inter-parental violence in childhood, and among women (OR = 2.25, CI: 1.40–3.61) and men (OR = 2.68, CI: 1.59–4.52) with a tolerant attitude toward IPV. The occurrence was higher among women who experienced childhood maltreatment by the parents (OR = 1.70, CI: 1.03–2.82) and women whose income was 2 million Korean Won(KRW) to 3 million KRW compared with women whose income was above 4 million KRW (OR = 1.97, CI: 1.10–3.55). The occurrence was lower among women with office jobs compared with other jobs (OR = 0.47, CI: 0.26–0.84). Based on the results of this study, early intervention in abusive families to reduce the negative impact of abuse experiences and witnessing inter-parental violence in childhood, and education and publicity for changing attitudes toward IPV are necessary at the individual and societal levels. The formation of policies for the stable workplace and income of women are required.
Learning temporal attention in dynamic graphs with bilinear interactions
Authors: Knyazev Boris , Augusta Carolyn , Taylor Graham W.
Published: March 2021

Reasoning about graphs evolving over time is a challenging concept in many domains, such as bioinformatics, physics, and social networks. We consider a common case in which edges can be short term interactions (e.g., messaging) or long term structural connections (e.g., friendship). In practice, long term edges are often specified by humans. Human-specified edges can be both expensive to produce and suboptimal for the downstream task. To alleviate these issues, we propose a model based on temporal point processes and variational autoencoders that learns to infer temporal attention between nodes by observing node communication. As temporal attention drives between-node feature propagation, using the dynamics of node interactions to learn this key component provides more flexibility while simultaneously avoiding issues associated with human-specified edges. We also propose a bilinear transformation layer for pairs of node features instead of concatenation, typically used in prior work, and demonstrate its superior performance in all cases. In experiments on two datasets in the dynamic link prediction task, our model often outperforms the baseline model that requires a human-specified graph. Moreover, our learned attention is semantically interpretable and infers connections similar to actual graphs.
Dynamic perceptive compensation for the rotating snakes illusion with eye tracking
Authors: Kubota Yuki , Hayakawa Tomohiko , Ishikawa Masatoshi
Published: March 2021

This study developed a dynamic perceptive compensation system for the rotating snakes illusion (RSI) with eye tracking. Large eye movements, such as saccades and blinks, were detected with an eye tracker, and perceptive compensation was dynamically performed based on the characteristics of RSI perception. The proposed compensation system considered three properties: spatial dependence, temporal dependence, and individual dependence. Several psychophysical experiments were performed to confirm the effectiveness of the proposed system. After the preliminary verification and determination of the temporal-dependent function for RSI perception, the effects of gaze information on RSI control were investigated. Five algorithms were compared using paired comparison. This confirmed that the compensation system that took gaze information into account reduced the RSI effect better than compensation without gaze information at a significance threshold ofp< 0.01, calculated with Bonferroni correction. Some algorithms that are dependent on gaze information reduced the RSI effects more stably than still RSI images, whereas spatially and temporally dependent compensation had a lower score than other compensation algorithms based on gaze information. The developed system and algorithm successfully controlled RSI perception in relation to gaze information. This study systematically handled gaze measurement, image manipulation, and compensation of illusory image, and can be utilized as a standard framework for the study of optical illusions in engineering fields.
The effect of human immunodeficiency virus infection on adverse events during treatment of drug-resistant tuberculosis: A systematic review and meta-analysis
Authors: Lazarus Gilbert , Tjoa Kevin , Iskandar Anthony William Brian , Louisa Melva , Sagwa Evans L. , Padayatchi Nesri , Soetikno Vivian
Published: March 2021

Background

Adverse events (AEs) during drug-resistant tuberculosis (DR-TB) treatment, especially with human immunodeficiency virus (HIV) co-infection, remains a major threat to poor DR-TB treatment adherence and outcomes. This meta-analysis aims to investigate the effect of HIV infection on the development of AEs during DR-TB treatment.

Methods

Eligible studies evaluating the association between HIV seropositivity and risks of AE occurrence in DR-TB patients were included in this systematic review. Interventional and observational studies were assessed for risk of bias using the Risk of Bias in Nonrandomized Studies of Intervention and Newcastle-Ottawa Scale tool, respectively. Random-effects meta-analysis was performed to estimate the pooled risk ratio (RR) along with their 95% confidence intervals (CIs).

Results

A total of 37 studies involving 8657 patients were included in this systematic review. We discovered that HIV infection independently increased the risk of developing AEs in DR-TB patients by 12% (RR 1.12 [95% CI: 1.02–1.22]; I2 = 0%, p = 0.75). In particular, the risks were more accentuated in the development of hearing loss (RR 1.44 [95% CI: 1.18–1.75]; I2 = 60%), nephrotoxicity (RR 2.45 [95% CI: 1.20–4.98], I2 = 0%), and depression (RR 3.53 [95% CI: 1.38–9.03]; I2 = 0%). Although our findings indicated that the augmented risk was primarily driven by antiretroviral drug usage rather than HIV-related immunosuppression, further studies investigating their independent effects are required to confirm our findings.

Conclusion

HIV co-infection independently increased the risk of developing AEs during DR-TB treatment. Increased pharmacovigilance through routine assessments of audiological, renal, and mental functions are strongly encouraged to enable prompt diagnosis and treatment in patients experiencing AEs during concomitant DR-TB and HIV treatment.
Relationship between exclusive breastfeeding and brain-derived neurotrophic factor in children
Authors: Berlanga-Macías Carlos , Sánchez-López Mairena , Solera-Martínez Montserrat , Díez-Fernández Ana , Ballesteros-Yáñez Inmaculada , Castillo-Sarmiento Carlos A. , Martínez-Ortega Isabel A. , Martínez-Vizcaíno Vicente
Published: March 2021

Objective

A positive relationship between breastfeeding and brain-derived neurotrophic factor (BDNF) in infants has been suggested due to the presence of BDNF in human milk. This study aimed to determine the relationship between exclusive breastfeeding and BDNF serum levels in Spanish schoolchildren.

Methods

A cross-sectional analysis including 202 schoolchildren, aged eight to 11 years, from Cuenca, Spain, was conducted. Information on sociodemographic and anthropometric variables, sexual maturation, birth weight and exclusive breastfeeding (‘no exclusive breastfeeding’, and exclusive breastfeeding for ≤6 and >6 months), and BDNF serum levels using an ELISA method were obtained. Covariance analyses (ANCOVA) were conducted to examine the relationship between serological BDNF and exclusive breastfeeding after controlling for potential confounders.

Results

ANCOVA models showed no significant differences in BDNF levels between children who were exclusively breastfed for more than six months versus those who were not (p > 0.05). No significant differences were observed by age group (eight to nine years versus 10 to 11 years; p > 0.05). Additionally, no clear negative trend in BDNF serum levels according to sexual maturation categories was found (p > 0.05).

Conclusion

These findings suggest that exclusive breastfeeding does not have a significant positive association on BDNF from eight to 11 years, since children who were exclusively breastfed did not have significantly higher BDNF levels than those who were not exclusively breastfed. Likewise, BDNF levels were not found to be negatively affected by hormonal development. Future research should examine the influence of exclusive breastfeeding on BDNF over the different developmental stages.
High quantities: Evaluating the association between cannabis use and propofol anesthesia during endoscopy
Authors: Imasogie Ngozi , Rose Rhiannon V. , Wilson Aze
Published: March 2021

Background

Endoscopy under propofol sedation has become a routine procedure. Given the number of Canadians undergoing an endoscopy annually, as well as the pervasive use of cannabis by many patients, understanding the effect of cannabis use on the propofol dose at endoscopy is highly relevant. We aimed to evaluate the association between cannabis exposure and the propofol dose needed to achieve adequate sedation at endoscopy.

Methods

A case-control study of individuals undergoing endoscopy was conducted at a single outpatient endoscopy clinic in London, Ontario between 2014 and 2017. Cases included all individuals with any self-reported cannabis exposure, while controls included all individuals without any self-reported history of cannabis use. Dose of propofol administered by a single anesthetist was collected on each subject as well as additional demographic and procedure-related covariates.

Results

Three hundred and eighteen participants were included (cases, n = 151; controls, n = 167). Cannabis exposure was associated with an increase in propofol dose (cases 0.33 mg/kg/minute ±0.24; controls, 0.18 mg/kg/minute ±0.11; p<0.0001). Cannabis exposure remained an independent predictor of propofol dose on multivariate linear regression accounting for other important covariates (p<0.0001). Daily cannabis users required a higher propofol dose than weekly or monthly users. Three procedural sedation-related complications occurred in the cannabis-exposed group, while none occurred in the unexposed group.

Conclusion

Our data suggest that cannabis use is significantly associated with the quantity of propofol needed for sedation at endoscopy. Further study is needed to better understand the molecular basis for this possible drug-drug interaction.
Tracing the History of DIY and Maker Culture in Germany’s Open Workshops
Authors: Sipos Regina , Franzl Kerstin
Published: March 2021

This article presents preliminary research findings on the history of Do-It-Yourself (DIY) and maker culture in Germany. It aims to identify historical, political, economic and societal shifts that have led to the existence of approximately 1000 makerspaces of various kinds in Germany today. The article summarises the beginnings of DIY in the 20th century in West Germany and East Germany. It focuses on how infrastructures supporting DIY were created out of necessity and economic considerations, how tools and spaces were offered as public service, the influence of counterculture movements and expression of political views through DIY and finally the use of DIY as a meaningful way to spend newfound leisure time and the phenomenon of state-funded vocational educational spaces. It aims to inspire further research elucidating the connections between broader societal contexts and DIY throughout the past century and its effects on maker culture today.
Removing Matter: Aristotle’s Criticism of Socrates the Younger
Authors: Argenti Andrea
Published: March 2021

This study is concerned with a crucial passage inMetaphysicsZ.11. After having established that only the formal parts of an object are stated in its definition and thus constitute its essence, Aristotle warns us against the process of separating the formal from the material parts. In doing so, he rejects the comparison proposed by Socrates the Younger. Mathematicals (e. g., shapes) cannot be equated to natural objects (e. g., animals) because some material parts must be included in accounting for the latter but not in accounting for the former. The goal of this article is to understand to what extent matter is essential to an object by examining the content of Aristotle’s criticism. My reconstruction shows that Aristotle is still committed to a formalist view. Socrates’ comparison is rejected because it removes matter not from the definitions of the subjects of metaphysics (substances), but from the definitions of their attributes.
The Human Vocation and the Question of the Earth: Karoline von Günderrode’s Philosophy of Nature
Authors: Nassar Dalia
Published: March 2021

Contra widespread readings of Karoline von Günderrode’s 1805 “Idea of the Earth (Idee der Erde)” as a creative adaptation of Schelling’s philosophy of nature, this article proposes that “Idea of the Earth” furnishes a moral account of the human relation to the natural world, one which does not map onto any of the more well-known romantic or idealist accounts of the human-nature relation. Specifically, I argue that “Idea of the Earth” responds to the great Enlightenment question concerning the human vocation, but from a distinctive romantic-idealist angle. I begin by demonstrating the influence of Fichte’s 1800Vocation of Humanityon Günderrode’s thinking, which involves an investigation of both Fichte’s text and Günderrode’s critical response to it. I then turn to “Idea of the Earth” where I analyse Günderrode’s understanding of nature and the self in light of her critique of Fichte, and thereby distinguish her position from Fichte’s and from the position espoused by her fellow romantics and idealists. By reading “Idea of the Earth” alongside Fichte’s text and Günderrode’s remarks on it, this article sheds new light on both Günderrode’s understanding and defence ofNaturphilosophie – against Fichte’s critique of it – and her distinctive contribution to romantic philosophies of nature.
Dimensions of Pleasure: A first Detailed Reconstruction of Plato’s ‘Tyrant Number’
Authors: Poetsch Christoph
Published: March 2021

In book IX of theRepublic,Socrates offers a strange mathematical calculation, which claims to prove that the tyrant lives exactly 729 times less pleasantly than the king. For the first time, a complete and detailed reconstruction of this difficult text and its underlying structure is offered in the present article. It thereby proves that the distinction between ‘pleasure’ and the ‘image of pleasure’ is one among the keys to understanding the passage. It is furthermore shown how the whole calculation is based on Plato’s ontology of dimensions and therefore proves that this theorem can be taken into account at least already for the time of theRepublic.
Verfügbarkeitsanalyse verfahrenstechnischer Anlagen durch stochastische Zustandsmodellierung unterschiedlicher Instandhaltungsstrategien
Authors: Markaj Artan , Fay Alexander
Published: March 2021

Die Verfügbarkeit einer verfahrenstechnischen Anlage kann durch die frühzeitige Auswahl geeigneter Anlagenkomponenten und die Entwicklung eines effektiven Instandhaltungskonzepts positiv beeinflusst werden. In dem vorliegenden Beitrag wird eine Methode zur Abschätzung der Anlagenverfügbarkeit für unterschiedliche Instandhaltungsstrategien in verfahrenstechnischen Anlagen aufgezeigt. Die Methode basiert auf der Kombination von Fehlermöglichkeits- und -einflussanalysen (FMEA), stochastischen Zustandsautomaten sowie Monte-Carlo-Simulationen. Aus den FMEA werden automatisiert stochastische Zustandsautomaten für die verfahrenstechnischen Anlagenkomponenten erzeugt, die in einem nachfolgenden Schritt zu einem gemeinsamen Anlagenmodell verknüpft werden. Durch die Auswahl unterschiedlicher Instandhaltungsmaßnahmen aus der FMEA lassen sich individuelle Zustandsautomaten der Anlagenkomponenten erzeugen. In einer zufallsbasierten Simulation werden die Anlagenmodelle hinsichtlich ihrer Anlagenverfügbarkeit untersucht und verschiedene Instandhaltungsstrategien miteinander verglichen.