bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Figure S1 from Glioblastoma Cortical Organoids Recapitulate Cell-State Heterogeneity and Intercellular Transfer
Authors: Mangena Vamsi , Chanoch-Myers Rony , Sartore Rafaela , Paulsen Bruna , Gritsch Simon , Weisman Hannah , Hara Toshiro , Breakefield Xandra O. , Breyne Koen , Regev Aviv , Chung Kwanghun , Arlotta Paola , Tirosh Itay , Suvà Mario L.
Published: February 2025

Supplementary Figure S1 describes the establishment and scRNA-seq profiling of GCOs, related to Figure 1.
Supplementary Table 1 from Tumor-Intrinsic Kinome Landscape of Pancreatic Cancer Reveals New Therapeutic Approaches
Authors: Xu Yi , Peng Xianlu L. , East Michael P. , McCabe Ian C. , Stroman Grace C. , Jenner Madison R. , Chan Priscilla S. , Morrison Ashley B. , Shen Emily C. , Hererra Silvia G. , Joisa Chinmaya U. , Rashid Naim U. , Iuga Alina C. , Gomez Shawn M. , Miller-Phillips Lisa , Boeck Stefan , Heinemann Volker , Haas Michael , Ormanns Steffen , Johnson Gary L. , Yeh Jen Jen
Published: February 2025

Supplementary Table 1.MIB_experimental_setup
Supplementary Table S6 from Copper Drives Remodeling of Metabolic State and Progression of Clear Cell Renal Cell Carcinoma
Authors: Bischoff Megan E. , Shamsaei Behrouz , Yang Juechen , Secic Dina , Vemuri Bhargav , Reisz Julie A. , D’Alessandro Angelo , Bartolacci Caterina , Adamczak Rafal , Schmidt Lucas , Wang Jiang , Martines Amelia , Venkat Jahnavi , Tcheuyap Vanina Toffessi , Biesiada Jacek , Behrmann Catherine A. , Vest Katherine E. , Brugarolas James , Scaglioni Pier Paolo , Plas David R. , Patra Krushna C. , Gulati Shuchi , Landero Figueroa Julio A. , Meller Jarek , Cunningham John T. , Czyzyk-Krzeska Maria F.
Published: February 2025

Differential gene expression in tumors from S3DF and S3RL patients.
Supplementary Table S2 from Copper Drives Remodeling of Metabolic State and Progression of Clear Cell Renal Cell Carcinoma
Authors: Bischoff Megan E. , Shamsaei Behrouz , Yang Juechen , Secic Dina , Vemuri Bhargav , Reisz Julie A. , D’Alessandro Angelo , Bartolacci Caterina , Adamczak Rafal , Schmidt Lucas , Wang Jiang , Martines Amelia , Venkat Jahnavi , Tcheuyap Vanina Toffessi , Biesiada Jacek , Behrmann Catherine A. , Vest Katherine E. , Brugarolas James , Scaglioni Pier Paolo , Plas David R. , Patra Krushna C. , Gulati Shuchi , Landero Figueroa Julio A. , Meller Jarek , Cunningham John T. , Czyzyk-Krzeska Maria F.
Published: February 2025

Steady-state metabolomics in CuHi and CuLo cells.
Data from Survivin Promotes Stem Cell Competence for Skin Cancer Initiation
Authors: Canato Sara , Sarate Rahul , Carvalho-Marques Sofia , Maia Soares Raquel , Song Yura , Monteiro-Ferreira Sara , Vieugué Pauline , Liagre Mélanie , Grossi Giancarlo , Cardoso Erik , Dubois Christine , Conway Edward M. , Schenone Silvia , Sánchez-Danés Adriana , Blanpain Cédric
Published: February 2025

Abstract
Stem cells (SC) and not progenitors (P) act as cells of origin of basal cell carcinoma (BCC). The mechanisms promoting BCC formation in SCs or restricting tumor development in Ps are currently unknown. In this study, we transcriptionally profiled SCs and Ps and found that Survivin, a pleiotropic factor that promotes cell division and inhibits apoptosis, was preferentially expressed in SCs. Using genetic gain- and loss-of-function mouse models, we showed that Survivin deletion in oncogene-expressing SCs prevents BCC formation. Survivin overexpression renders Ps competent to BCC formation by promoting cell survival and division while preventing apoptosis and differentiation. We identified Serum glucocorticoid–regulated kinase 1 (Sgk1) as a key downstream factor of Survivin and that its inhibition prevents BCC formation. This study uncovers the role and mechanisms by which Survivin regulates the competence of SCs to initiate BCC formation, promoting the survival of oncogene-expressing SCs and self-renewing division while restricting differentiation and apoptosis.
Significance:
This study identifies Survivin as a key regulator of the different ability of SCs and Ps to initiate skin cancer. Survivin expression in oncogene-targeted SCs is essential for their survival and self-renewal and to prevent their differentiation and apoptosis, allowing SCs and not Ps to initiate skin cancer.
Stromal KITL/SCF maintains pancreas tissue homeostasis and restrains tumor progression
Authors: Oñate M. Kathrina. , Oon Chet , Bhattacharyya Sohinee , Low Vivien , Chen Canping , Zhao Xiaofan , Arnold Frank , Yan Ziqiao , Pramod Sneha , Hang Yan , Ho Yu-Jui , Lowe Scott W. , Kim Seung K. , Xia Zheng , Sherman Mara H.
Published: February 2025

Components of normal tissue architecture serve as barriers to tumor progression. Inflammatory and wound-healing programs are requisite features of solid tumorigenesis, wherein alterations to immune and non-immune stromal elements enable loss of homeostasis during tumor onset. The precise mechanisms by which normal stromal cell states limit tissue plasticity and tumorigenesis, and which are lost during tumor progression, remain largely unknown. Here we show that healthy pancreatic mesenchyme expresses the paracrine signaling molecule KITL, also known as stem cell factor, and identify loss of stromal KITL during tumorigenesis as tumor-promoting. Genetic inhibition of mesenchymal KITL in the contexts of health, injury, and cancer together indicate a role for KITL signaling in maintenance of pancreas tissue architecture, such that loss of the stromal KITL pool increased tumor growth and reduced survival of tumor-bearing mice. Together, these findings implicate loss of mesenchymal KITL as a mechanism for establishing a tumor-permissive microenvironment.
LINE-1 ORF1p Mimics Viral Innate Immune Evasion Mechanisms in Pancreatic Ductal Adenocarcinoma
Authors: You Eunae , Patel Bidish K. , Rojas Alexandra S. , Sun Siyu , Danaher Patrick , Ho Natalie I. , Phillips Ildiko E. , Raabe Michael J. , Song Yuhui , Xu Katherine H. , Kocher Joshua R. , Richieri Peter M. , Shin Phoebe , Taylor Martin S. , Nieman Linda T. , Greenbaum Benjamin D. , Ting David T.
Published: February 2025

Repeat element viral mimicry is a common feature in pancreatic ductal adenocarcinoma (PDAC) that require mechanisms to manage this repeat “viral” load and attenuate innate immune responses. Here, we show that the LINE-1 ORF1 protein (ORF1p) in PDAC cells plays a role in shielding repeat RNAs from activating a pathogen recognition receptor (PRR)-mediated antiviral response that is independent of retrotransposition. Suppression of ORF1p using short hairpin RNA induces innate immune responses through the dsRNA sensors RIG-I and MAVS. Low ORF1p PDAC cell lines have suppressed expression of PRRs demonstrating convergent mechanisms to suppress innate immune signaling. Localization of ORF1p in processing bodies (PBs) with the dsRNA helicase MOV10 were found important for these antiviral responses. Loss of ORF1p resulted in significant growth reduction in tumorspheres and mouse xenografts with an enriched epithelial cell state, and high ORF1p expression was associated with worsened survival in a cohort of human PDAC patients.
Selective STING Activation in Intratumoral Myeloid Cells via CCR2-Directed Antibody Drug Conjugate TAK-500
Authors: Appleman Vicky A. , Matsuda Atsushi , Ganno Michelle L. , Zhang Dong Mei , Rosentrater Emily , Maldonado Lopez Angel E. , Porciuncula Angelo , Hatten Tiquella , Christensen Camilla L. , Merrigan Samantha A. , Lee Hong Myung , Lee Min Young , Wang Charlotte I. , Dong Linlin , Huang Jian , Iartchouk Natasha , Wang Jianing , Xu He , Yoneyama Tomoki , Piatkov Konstantin I. , Haridas Satyajeet , Harbison Carole E. , Gregory Richard C. , Parent Alexander , Lineberry Neil , Arendt Chris , Schalper Kurt A. , Abu-Yousif Adnan O.
Published: February 2025

The tumor microenvironment (TME) in solid tumors contains myeloid cells that modulate local immune activity. STING signaling activation in these myeloid cells enhances local type I interferon (IFN) production, inducing an innate immune response that mobilizes adaptive immunity and reprograms immunosuppressive myeloid populations to drive antitumor immunity. Here, we generated TAK-500, an immune cell directed antibody drug conjugate (iADC), to deliver a STING agonist to CCR2+ human cells and drive enhanced antitumor activity relative to non-targeted STING agonists. Preclinically, TAK-500 triggered dose-dependent innate immune activation in vitro. In addition, a murine TAK-500 iADC surrogate enhanced innate and adaptive immune responses both in vitro and in murine tumor models. Spatially resolved analysis of CCR2 and immune cell markers in the TME of >1,000 primary human tumors showed the CCR2 protein was predominantly expressed in intratumoral myeloid cells. Collectively, these data highlight the clinical potential of delivering a STING agonist to CCR2+ cells.
Table S2 from Age at First Full-term Pregnancy and Other Reproductive Factors Are Associated with Mammographic Breast Density in Postmenopausal Women: A Study in Flanders, Belgium
Authors: Vandeloo Magda J. , Kellen Eliane , Fang Carolyn Y. , Ross Eric A. , Vancoillie Liesbeth , Bruckers Liesbeth M. , Neven Kristof Y. , Bijnens Esmée M. , Nawrot Tim S. , Van Ongeval Chantal
Published: February 2025

Table S2: Results from the univariate analysis for the volumetric breast density (VBD). For FFTP, we used the proc NLIN procedure, for the others a GLM. Multiplicative estimates provided are calculated according to eβ for the given unit change
Table 5 from Age at First Full-term Pregnancy and Other Reproductive Factors Are Associated with Mammographic Breast Density in Postmenopausal Women: A Study in Flanders, Belgium
Authors: Vandeloo Magda J. , Kellen Eliane , Fang Carolyn Y. , Ross Eric A. , Vancoillie Liesbeth , Bruckers Liesbeth M. , Neven Kristof Y. , Bijnens Esmée M. , Nawrot Tim S. , Van Ongeval Chantal
Published: February 2025

Results from the ordinal logistic regression model for BI-RADS. The model was stratified based on the FFTP results from the GLAND and VBD models: “≤25.7 years” and “>25.7 years.”
Table 3 from Age at First Full-term Pregnancy and Other Reproductive Factors Are Associated with Mammographic Breast Density in Postmenopausal Women: A Study in Flanders, Belgium
Authors: Vandeloo Magda J. , Kellen Eliane , Fang Carolyn Y. , Ross Eric A. , Vancoillie Liesbeth , Bruckers Liesbeth M. , Neven Kristof Y. , Bijnens Esmée M. , Nawrot Tim S. , Van Ongeval Chantal
Published: February 2025

Results from the PROC NLIN model for the GLAND.
A case of possible infusion-related reactions caused by palonosetron
Authors: Kadono Toru , Kodama Hiroyuki , Yukami Hiroki , Yamaguchi Toshifumi , Nishikawa Hiroki
Published: February 2025

Introduction: An infusion-related reaction (IRR) is an adverse event that typically occurs when cytotoxic drugs or monoclonal antibodies are administered. Palonosetron, the 5-hydroxytryptamine 3 receptor antagonists, is commonly used to prevent chemotherapy-induced nausea and vomiting. IRRs due to palonosetron are very rare, with only two reports of anaphylactic shock due to palonosetron to date. We report a case with an IRR other than anaphylaxis.
Presentation: A 75-year-old man with metastatic pancreatic cancer was receiving palliative chemotherapy. The patient repeatedly developed mild chills, shivering, fever and hypertension during or after infusion of cytotoxic agents such as liposomal irinotecan, gemcitabine, albumin-bound paclitaxel or oxaliplatin. Finally, as the IRR developed immediately after palonosetron, we concluded that palonosetron, which had been used as premedication in all previous regimens in which IRRs had occurred, was the causative agent.
Discussion: Hypertension was considered to be one of the symptoms of IRR, although not typical. The rarity of palonosetron-induced IRRs and the delayed onset of IRRs made it difficult to establish that palonosetron was the cause of the IRRs. This report presents a rare case of IRR caused by palonosetron and details the course of IRR with palonosetron, which may help in the early recognition and appropriate management of future IRR with palonosetron.
The value of IL-6, D-D, and WBC tests in the diagnosis of severe pneumonia
Authors: Xu Tianfu , Yan Seyan , Huang Saiping
Published: February 2025

Introduction: This paper aimed to unravel the value of interleukin-6 (IL-6), D-dimer (D-D), and white blood cell (WBC) tests in the diagnosis of severe pneumonia.
Methods: Sixty cases of pneumonia patients were selected as the observation group, which were divided into the non-severe group (35 cases) and the severe group (25 cases) following the severity of the disease; and 50 health check-up participants in the same time period were chosen as the control group. The general information of the control and the observation groups were compared; IL-6, D-D, and WBC levels were observed in the non-severe and the severe groups. Logistic multivariate regression analysis was implemented to analyze the independent factors predicting severe pneumonia, and the ROC curve was adopted to observe the diagnostic value of IL-6, D-D, and WBC for severe pneumonia.
Results: There was no difference in general information between the observation and the control groups, and between the severe and the non-severe groups (P > 0.05); IL-6, D-D, and WBC levels in the severe group were markedly higher relative to the non-severe group; the multivariate logistic regression analysis showed that IL-6 (P < 0.05, 95% CI: 1.076-1.443) and D-D (P < 0.05, 95% CI: 1.367-66.079) were independent factors predicting severe pneumonia; the ROC curve analysis revealed that the AUCs of IL-6, D-D, and WBC were 0.957, 0.874, and 0.639, respectively; the combined AUC of the three was 0.978, demonstrating that the predictive value of the combined test was higher than that of the single test.
Conclusion: IL-6, D-D, and WBC are significantly elevated in severe pneumonia and have predictive value in severe pneumonia.
Presenting Natural Continuous Speech in a Multisensory Immersive Environment Improves Speech Comprehension and Reflects the Allocation of Processing Resources in Neural Speech Tracking
Authors: Frei Vanessa , Giroud Nathalie
Published: February 2025

Successful speech comprehension, though seemingly effortless, involves complex interactions between sensory and cognitive processing and is predominantly embedded in a multisensory context, providing acoustic and visual speech cues. Adding the perspective of ageing, the interaction becomes even more manyfold. The impact of cognitive load on speech processing has been investigated, however, characterized by a lack of realistic speech material and multimodality. In this study, we therefore investigated the effects of memory load on naturalistic immersive audiovisual speech comprehension in older adults with varying degrees of hearing impairment and cognitive capacities. By providing natural continuous multisensory speech, provided through virtual reality, we created an immersive three-dimensional visual of the speaker and manipulated the memory load of the natural running speech inspired by a traditional n-back task. This allowed us to quantify neural speech envelope tracking via EEG and behavioral speech comprehension in varying modalities and memory loads in a highly controllable environment, while offering a realistic conversational experience. Neural speech tracking depends on an interaction between modality and memory load, moderated by auditory working memory capacity. Under low memory load, there is an increase in neural speech tracking in the immersive modality, particularly strong for individuals with low auditory working memory. Visually induced performance improvement is observed similarly in high and low memory load settings on a behavioral level. We argue that this dynamic reflects an allocation process of sensory- and cognitive processing resources depending on the presented sensory- and cognitive load of natural continuous speech and individual capacities.
Navigating Dual Identities
Authors: Minh Tran Ngoc
Published: February 2025

This study examines the cultural identity negotiations of young Vietnamese and second-generation Vietnamese individuals in Britain, highlighting the importance of historical and cultural awareness in navigating a dual cultural heritage. Using Hall’s cultural identity notion and Croucher and Kramer’s cultural fusion model, and a qualitative research design, the study analyses long interviews to explore how the participants’ understanding of their Vietnamese roots influences their experiences of belonging and cultural identity construction. The findings reveal that a strong connection to heritage fosters resilience, whereas a weak connection can create internal struggles in navigating a multicultural world. The study contributes to diaspora literature by emphasising the dynamic interplay between acculturation and cultural maintenance, the complexities of intergenerational identity transmission, and the role of interpersonal connection, cultural practices and internal determination in a hyperconnected world. The research bridges theoretical frameworks and empirical insights, offering ways to support second-generation immigrants in their identity formation.
Inter-State Communications before United Nations Human Rights Treaty Bodies: Distinctive Features and Evolving Aims
Authors: Garciandia Rosana
Published: February 2025

In 2018, the United Nations (UN) Committee on the Elimination of Racial Discrimination (CERD Committee) received its first three inter-State communications since the Convention it monitors was adopted in 1965: Palestine v Israel, Qatar v Saudi Arabia and Qatar v United Arab Emirates. These were the first inter-State cases ever initiated before this or any other UN human rights treaty body, activating a mechanism which had laid dormant for decades. In August 2024, the ad hoc conciliation commission for Palestine v Israel published its final report, marking the first time that an inter-state communication before a UN treaty body reaches its final phase. The awakening of the mechanism has inspired new lines of research, testing the mechanism in the practice of the CERD Committee and triggering analysis of its procedural features in this and other treaties. What remains underexplored is the connection between those features and the aims that States and other actors envisage for the procedure. This article explores that connection and contends that any revision of the features of the mechanism that its use may bring should be informed by its aims, which are multiple and evolving. The article proceeds in three parts. The first part analyses distinctive features of the mechanism. The second part explores the evolution in the aims of inter-State communications in connection with those features. The third part concludes by reflecting on how those connections could inform forthcoming reforms of the mechanism.
Exploring the Lived Experience of Early Taiwan Chinese Immigrants in North America
Authors: Chiang Lan-Hung Nora
Published: February 2025

This research focuses on those who left Taiwan for the United States and Canada, eventually planting their roots in North America. Case studies based on intensive multi-sited fieldwork conducted between 2008 and 2014 in five North American cities reveal their motivations for migration, the processes involved, and their lived experiences. They survived various challenges, such as gaining proficiency in English, adapting to different customs, enduring cold weather and overcoming loneliness. The qualitative methods used in this research gave voice to forty-two early-era Taiwan Chinese immigrants, demonstrating their roles as trailblazers for new immigrants from both Taiwan and Mainland China. A good educational background in Taiwan, further studies in the host countries, entrepreneurship, and the ability to use local resources were essential factors to help them in building successful careers. A majority settled permanently in their adopted cities, which became their homes.
Hybridizing of glass sheet molding compounds (SMC) with recycled carbon fiber (rCF)
Authors: Chahine Georges , Meraki Yalcin , Barakat Abdallah , Hess Jocelyn , Fono Tamo Romeo , Vaidya Uday
Published: February 2025

Sheet Molding Compound (SMC) is a widely used composite material, particularly in automotive applications, due to its cost-effectiveness, lightweight properties, and adaptability for complex shapes. While E-glass is commonly used as reinforcement in SMC, its strength and stiffness are limited compared to carbon fiber (CF). Previous research has focused on continuous-discontinuous SMC hybrids, combining continuous CF with glass fiber substrates, but these approaches are costly and complex to manufacture. This study explores a novel discontinuous-discontinuous hybrid SMC that combines E-glass SMC (G-SMC) with recycled carbon fiber (rCF) mats, aiming to enhance mechanical properties without a significant cost increase. Two materials were produced, one with and one without rCF, and were tested for flexural, tensile, interlaminar shear, and impact properties. Failure mechanisms were also examined through digital imaging. This approach demonstrates the potential for a cost-effective and practical SMC hybrid suitable for commercial applications in the automotive industry.
A Measure for Assessing Academic Virtues and Strengths in the University Setting: Construction and Initial Examination of Structure and Correlates
Authors: Green Zane Asher , Karuppannan Gunasegaran
Published: February 2025

This research demonstrates the construction and preliminary examination of the structure of a domain-specific measure, namely the Character Strengths Scale for University Students (CSSUS). Reflecting the use of the 24 Values in Action (VIA) strengths in the study domain, the CSSUS likely adds greater specificity to the findings pertinent for devising and implementing meaningful strategies for furthering academic development, student learning, and well-being in higher education. Derived from best practices, the item generation process of the CSSUS was based on four steps: (1) identification of the domain, (2) item generation, (3) content validity, and (4) field pre-testing of the items of the CSSUS. The initial examination of the factors of the CSSUS was based on a sample of 540 undergraduate and graduate students studying in Lahore, Pakistan. Results provided evidence of a four-factor structure of the CSSUS. Furthermore, the CSSUS and its subscales were positively related to academic achievement and the measures of satisfaction with life, positivity, and student self-efficacy. In addition, the CSSUS and its subscales were negatively related to the measure of academic burnout. The correlations provided evidence of the concurrent criterion-related validity of the scale. Moreover, female students reported higher levels of love and spirituality, whereas male students higher levels of leadership, creativity, and bravery. Also, there was no significant difference in the use of academic virtues with regard to gender, level of education (undergraduate and graduate), study discipline (agricultural sciences, humanities, health sciences, and engineering technology), type of university (public and private), and level of academic performance (low, medium, and high). The theoretical contribution and practice implications of the results are discussed. Limitations of the study and prospects for future research are also discussed.
‘Bear with My Word of Comfort’: Consolatory Strategies in the Letter to the Hebrews
Authors: Pracht Erich Benjamin
Published: February 2025

In this study, I argue that the book of Hebrews contains five consolatory strategies that recur in the letters of Cicero, Seneca, and Plutarch. I relate Hebrews to the Greco-Roman consolatory tradition in terms of general modes of socio-literary practice that cut across traditional dividing lines such as ethnicity, language, and philosophical outlook. In this way, I show how Greco-Roman consolation, which is typically overlooked in scholarship on Hebrews, sheds informative light on the author’s literary strategies and aims. I situate Hebrews against the background of hostilities faced by the original audience and the destruction of the temple, both of which caused distress and disorientation and thereby created the need for consolation. I argue that, given the historical circumstances that provided the occasion for writing and the consolatory strategies the author deploys, consolation is among the author’s primary literary objectives. As a result, I find that the author’s designation of his work in Heb. 13.22 is best translated as a ‘word of comfort’.
Detecting Deception Through Linguistic Cues: From Reality Monitoring to Natural Language Processing
Authors: Loconte Riccardo , Battaglini Chiara , Maldera Stéphanie , Pietrini Pietro , Sartori Giuseppe , Navarin Nicolò , Monaro Merylin
Published: February 2025

Detecting deception in interpersonal communication is a pivotal issue in social psychology, with significant implications for court and criminal proceedings. In this study, four experiments were designed to compare the performance of natural language processing (NLP) techniques and human judges in detecting deception from linguistic cues in a dataset of 62 transcriptions of video-taped interviews (32 genuine and 30 deceptive). The results showed that machine-learning algorithms significantly outperform naïve (accuracy = 54.7%) and expert judges (accuracy = 59.4%) when trained on features from the reality monitoring (RM) and cognitive load frameworks (accuracy = 69.4%) or on features automatically extracted through NLP techniques (accuracy = 77.3%) but not when trained on the RM criteria alone. This evidence suggests that NLP algorithms, due to their ability to handle complex patterns of linguistic data, might be useful for better disentangling truthful from deceptive narratives, outperforming traditional theoretical models.
Study on in-plane mechanical properties of the novel thickness gradient honeycomb structures
Authors: Guo Junlan , Li Lizheng , Zhu Jiamei , He Qiang , Qu Rui
Published: February 2025

As a lightweight protective structure, auxetic honeycombs have a broad application in engineering. In this study, gradient characteristics was introduced into a novel enhanced auxetic honeycomb (NEH). Positive, negative, symmetric positive and symmetric negative gradient NEH (P-NEH, N-NEH, SP-NEH and SN-NEH) were constructed by varying the wall thicknesses, and the relative densities were deduced. The dynamic responses of NEH and reentrant honeycomb (RH) were compared by numerical methods, and it was found that NEH has superior mechanical properties. Subsequently, the in-plane impact dynamics of the NEH were disclosed, and the distortion modes, dynamic response curves, platform stresses, Poisson's ratio distributions, and energy-absorbing effects were examined for various gradient distributions and impact velocities. It was found that the gradient distribution and impact velocity significantly affected the impact resistance of gradient NEHs. The platform stress increased with increasing velocity, and there was a significant difference between the platform stresses of the gradient NEHs at the same impact velocity. Among these, the N-NEH exhibits the highest plateau stress, suggesting that it can effectively enhance the energy absorption capability. When impacted at low speed, the specific energy absorption (SEA) of then N-NEH was 148.2% and 108.1% higher than that of the P-NEH and SN-NEH, respectively. At medium-velocity impact, the SEA of the N-NEH was 124.6%, 28.9%, and 112.9% higher than that of the others, respectively. At high-speed impact, the gradient honeycomb is more susceptible to speed influence, and the N-NEH shows extremely outstanding impact resistance.
Training programs in communication skills for healthcare professionals caring for children with life-limiting and life-threatening conditions and their families: A systematic review of healthcare professionals’ behavioral impact and children’s health outcomes
Authors: Yamaji Noyuri , Suzuki Daichi , Sasayama Kiriko , Nitamizu Aya , Yamamoto Mami , Ikeda Mari , Ota Erika
Published: February 2025

Background:

Effective communication has potential benefits for children, their families, and healthcare professionals. Although communication skills training programs are essential for healthcare professionals, their effects remain unclear.

Aim:

This review summarized existing communication skills training programs and evaluated their impact on healthcare professionals’ behavior and the health outcomes of children with life-threatening conditions and their families.

Design:

This systematic review was performed in accordance with the Cochrane Handbook version 6.4.

Data sources:

On January 21, 2024, we searched the following databases: Cochrane Central Register of Controlled Trials, PubMed, MEDLINE, Embase, PsycINFO, and CINAHL. The included studies’ risk of bias was assessed using a revised Cochrane risk-of-bias tool for randomized controlled trials 2. Owing to insufficient data and high heterogeneity, we could not perform a meta-analysis, so the findings were described narratively.

Results:

We identified nine studies, which included various diseases, training programs, and outcome measurement tools and timings. Among the nine studies, five of the six studies that assessed healthcare professionals’ behaviors reported that the interventions had improved them (low certainty of evidence). Only two studies reported on the quality of life and anxiety experienced by children and their families, with no clear difference between intervention and control groups.

Conclusions:

Communication skills training for healthcare professionals may improve their behaviors toward children with life-threatening conditions and their families. Measurement tools and timings must be standardized. Future research should develop training programs and assess their impact on children and their families, incorporating the perspective of children.
Exploring Macrolevel Dynamics: Unraveling the Impact of Privacy on Customer Welfare and the Moderating Role of Market Type (B2B vs. B2C)
Authors: Sabri Ouidade , Ziane Ydriss
Published: February 2025

This study aims to fill a significant gap in the existing literature by thoroughly examining the relationship between privacy and customer welfare across different market types at the macrolevel, with a specific emphasis on the B2B (Business-to-Business) and B2C (Business-to-Consumer) sectors. While prior research has often assumed a uniform positive impact of privacy at the individual and micro levels, this study seeks to uncover potential disparities in this relationship. Using an expansive panel dataset from FactSet comprising 620 listed firms globally during the 2022 research period and employing the comprehensive welfare and privacy metrics developed by the Sustainability Accounting Standards Board (SASB), this study conducts cross-sectional analyses through regression-based modeling, revealing that privacy positively influences B2B customer welfare but lacks a notable effect on the B2C sector. While establishing the critical moderating role of market types on the relationship between privacy and welfare contributes significantly to research, this analysis underscores the pressing necessity for tailored regulatory frameworks in both sectors. It advocates for flexible policymaking and collaboration with stakeholders to effectively promote customer welfare while striking a balance between privacy protection and welfare promotion.
Efficacy and safety of laquinimod versus placebo in relapsing-remitting multiple sclerosis: a systematic review and meta-analysis of randomized controlled trials
Authors: Zeb Khan Malik Waleed , Ali Aizaz , Hussain Amna , Khan Safeena , Tahir Ammara , Khan Muhammad Haris , Azeem Touba , Moeez Abdul , Monis Arysha , Mian Aban Masaud , Khattak Fazia , Ali Moosa , Ikram Jibran
Published: February 2025

Objective

To investigate the safety and efficacy of laquinimod in treating relapsing-remitting multiple sclerosis (RRMS).

Methods

An extensive electronic search was conducted across PubMed, Embase, Cochrane Database of Systematic Reviews, and ClinicalTrials.gov to identify suitable studies. Risk of bias was assessed using Cochrane’s Risk of Bias tool. Statistical analysis was performed using RevMan 5.4.1.

Results

The meta-analysis of four randomized controlled trials including 3665 patients found that laquinimod significantly reduced the annualized relapse rate compared with placebo (mean difference = −0.08, 95% confidence interval [CI] = −0.12, −0.04, I2 = 0%). For disability progression confirmed at 3 months, laquinimod provided a significant advantage over placebo (hazard ratio [HR] = 0.75, 95% CI = 0.59, 0.96, I2 = 25%), whereas no benefit was achieved at 6 months (HR = 0.69, 95% CI = 0.45, 1.06, I2 = 66%). Laquinimod was also significantly better than placebo in maintaining a relapse-free status (risk ratio [RR] = 1.14 95% CI = 1.06, 1.22, I2 = 10%). Laquinimod had a comparable safety profile as placebo (RR = 1.06, 95% CI = 0.81, 1.39, I2 = 33%).

Conclusions

These findings support the efficacy of laquinimod in managing RRMS but necessitate careful monitoring during treatment.
Spatial transcriptomics defines the cell-specific RNA landscape of equine dorsal root ganglia
Authors: Finno Carrie J. , Rogers Stefan-Laural , Donnelly Callum G. , Affolter Verena K. , Woolard Kevin , Miller Andrew D. , Bellone Rebecca R. , Petersen Jessica L.
Published: February 2025

Equine spinal neurodegenerative conditions are frequently encountered in sport and racing horses and may be career-ending diagnoses. To further define the spatial transcriptomic landscape of equine dorsal root ganglia (DRG) in healthy adult horses, we investigated gene expression differences in distinct DRG regions using the GeoMx Digital Spatial Profiling from NanoString. Four human cell markers demonstrated high fidelity for equine cells; microtubule-associated protein 2 (MAP2), myelin basic protein (MBP), allograft inflammatory 104 factor 1/ionized calcium-binding adaptor molecule 1 (IBA1/AIF1), and Syto83 nuclear marker. Geometric regions of interest were then selected as MBP-rich, IBA1-high, and IBA1-low, and gene expression was compared. Experimental validation was achieved, with genes involved in myelination enriched in MBP-rich regions, and the identification of glia-specific genes enriched in IBA1-high regions. Thus, spatial transcriptomics with human cell markers was successful in equine DRG and can now be applied to determine cell-specific transcriptional changes during disease states.
Congruency between viewers’ movements and the region of the display being sampled speeds up search through an aperture
Authors: Crowe Emily M. , Vorgia Danai T. , Brenner Eli
Published: February 2025

Searching for a target amongst distractors is faster when moving an aperture over the search display than when moving the search display beneath an aperture. Is this because when moving the aperture, each item is sampled at a different position, while when moving the search display, all items are sampled at the same position? When moving the aperture, it might therefore be easier to keep track of where one has already searched. Experiment 1 showed that, when the extent of the search display is visible to provide an additional reference frame, participants still found targets faster when moving the aperture. Experiment 2 showed that, even when the aperture and search display constantly moved around the screen together so that remembering where on the screen one had already searched is less useful, participants still found targets faster when moving the aperture. Experiment 3 showed that inverting the mapping between movements of the mouse and the item they were toggled to reversed the outcome: for the inverted mapping, search was faster when moving the search display than when moving the aperture. We conclude that the congruency between the user's movements and the spatial region of the search display that they are sampling from is critical for speeding up search.
Numerical simulation on the motion of bubbles and inclusion removal in the swirling long nozzle
Authors: Wang Hongjing , Zhang Lin , Li Tao , Huang Xing , He Wen , Ju Liying , Tan Min , Tang Guozhang , Wang Xiaofeng
Published: February 2025

Abstarct

Improving the removal rate of inclusions is crucial for enhancing the quality of steel products. The paper designs a swirling flow generator (SFG), which is installed between the ladle and the long nozzle, to optimize the efficiency of converting gravitational potential energy of the molten steel into swirling kinetic energy within the long nozzle. Compared the effects of the discrete phase model (DPM) and the DPM-volume of fluid (VOF) on the removal of inclusions during bubble injection, where the collision elimination behavior of inclusions and bubbles was simulated using a self-developed user-defined function (UDF), which optimizes the collision determination between bubbles and inclusions from a time point approach to a time step method, enabling full-process monitoring of bubble-inclusion collisions within discretized time steps. The results indicate that the application of the SFG significantly optimizes the flow field in the long nozzle, compared to the traditional long nozzle (TLN), the inclusion removal rate in the swirling long nozzle could be increased by approximately 50% and 20% using the DPM model and DPM-VOF coupled model, respectively.
Where the Streetlights Come Alive
Authors: Falzano Rebecca
Published: February 2025

At Branson's lakefront entertainment retail destination, the ever-evolving lighting scheme wasn't just designed, it was invented
Cfls in America: Lessons Learned on the Way to Market
Authors: Brodrick James
Published: February 2025

The burgeoning solid-state lighting community can learn much from compact fluorescent's rocky road to consumer acceptance
Restyling A Retail Classic
Authors: Barr Vilma
Published: February 2025

Neiman Marcus in the Houston Galleria hadn't changed much in the 39 years since it opened, but a competitor's makeover prompted a renovation that once again communicates the company aesthetic
Lit for A Queen
Authors: Falzano Rebecca
Published: February 2025

When the Queen Victoria embarked on her maiden ocean voyage, it was smooth sailing. Lighting the cruise ship, however, proved to be a bit more challenging
Top-Side Techniques
Authors: Berg Jeffrey
Published: February 2025

The author looks at the various systems used to usher daylight into the building
How to Build A Lighting Professional
Authors: Bartholomew Edward
Published: February 2025

A common set of characteristics and skills are the bricks and mortar that form the aspiring lighting pro
Plda Aplenty
Authors: Shrum Glenn
Published: February 2025

The Professional Lighting Designers’ Association has developed a range of programs and resources for academics, young professionals and just about everyone in between
Light at Night in Our Bedrooms
Authors: Figueiro Mariana G. , Rea Mark S. , Brons Jennifer A.
Published: February 2025

Researchers from the LRC discuss what it may mean in terms of breast cancer risk
Effects of Schematic Chunking Intervention on Enhancing Geometry Performance in High School Students With Geometry Learning Difficulties
Authors: Al Hadi Moosa , Zhang Dake
Published: February 2025

Geometry education is an important aspect of science, technology, engineering, and mathematics (STEM) education, but it is often overlooked in K–12 education in the United States. Chunking strategy reduces the cognitive load demanded in the processing of information, and it has been applied as a testing accommodation for high school students with math difficulties (MD) in prior research. This study extended prior research from test accommodation to examining the effect of schematic chunking as an intervention on the geometry performance of high schoolers with MD. A multiple probe design across participants was used. Three tenth graders with difficulties in learning geometry participated in this study. We revealed that the schematic chunking strategy improved all three students’ performance in solving high school geometry problems, with varying improvement on two generalization measures. Qualitative analysis suggested that all three participants adopted the schematic chunking strategy; however, some barriers interfered with their successful use of the chunking strategy. Individual differences in responses to the schematic chunking intervention suggested that the effectiveness of the chunking strategy depends on the assumption that students have the prerequisite expertise to recognize meaningful schematic chunks and can retrieve related theorems from long-term memory. We recommended that schematic chunking strategy should be integrated with, rather than replacing, geometry content instruction.
Quantification des relations entre variables catégorielles ordinales Application aux métriques suivies par les baromètres de satisfaction
Authors: Bultez Alain , Laurent Gilles , Lemay Laurent
Published: February 2025

Résumé

Perceptions, attitudes, intentions, . . ., sont, à des fins de segmentation des marchés, de suivi ou de prévision des réactions des consommateurs, régulièrement étudiées. Ces composantes cognitives, affectives, ou comportementales, sont le plus souvent mesurées par les réponses à des questions à choix multiples : modalités prenant la forme d’un nombre limité de classes ordonnées, avec points d’ancrage, mais pas toujours toutes sémantiquement différenciées. L’analyse statistique de telles données, qualitatives, dites catégorielles ordinales, conduit généralement à les encoder numériquement et à les considérer quantitatives. Ce faisant, on leur attribue alors des propriétés dont elles ne sont pas dotées, avec pour conséquence des risques de biais. Pour les traiter correctement nous proposons une paramétrisation économétrique des relations entre de telles variables, respectant strictement leur contenu informatif.

Alliant techniques de régression multinomiale cumulative et monotone, ainsi que de rééchantillonnage aléatoire, notre méthodologie permet de tester rigoureusement si des métriques de feedback de nature catégorielle ordinale pourraient être assimilées à des mesures d’intervalles. Nous l’expérimentons de manière concluante sur deux grands échantillons résultant des baromètres de satisfaction des clients de deux opérateurs de télécommunications, concurrents. Ainsi, nous montrons combien la disposition de leurs clients à les recommander s’explique par les satisfactions procurées par leurs produits-services. Subsidiairement, cette double étude de cas invalide le très populaire Net Promoter Score (NPS) censé synthétiser des distributions de degrés de vraisemblance d’une participation des consommateurs à la promotion de leurs marques favorites par bouche-à-oreille.
The Role of Moral Injury in the Relationship Between Intimate Partner Violence and Psychological Distress
Authors: Kanter Rachel L. , Hassija Christina M.
Published: February 2025

Intimate partner violence (IPV) is consistently associated with deleterious mental health outcomes. Moral injury, a distinct form of trauma that can arise from witnessing, engaging in, failing to prevent, or being the victim of acts that conflict with one’s moral beliefs, is similarly associated with adverse mental health. However, despite the conceptual relation between moral injury and IPV, no previous research to these authors’ knowledge has examined this relationship. The present study investigated IPV experiences (perpetration and victimization), moral injury, and psychological distress in a sample of diverse college students ( N = 152). We hypothesized that IPV experiences would be positively associated with moral injury and psychological distress, that moral injury would be positively associated with psychological distress, and that moral injury would mediate the relationship between IPV experiences and psychological distress. Results revealed significant positive correlations between IPV experiences, moral injury, and psychological distress. Mediation analyses revealed that both self-directed and other-directed moral injury fully mediated the relationship between IPV perpetration and psychological distress, while only self-directed moral injury emerged as a significant mediator between IPV victimization and psychological distress. These findings highlight the complex relationships among IPV, moral injury, and psychological distress, and underscore the importance of assessing moral injury in IPV-affected individuals. The present study addresses gaps in the literature by examining moral injury in a diverse, civilian sample of IPV survivors and perpetrators.
Turkey’s Rising Tide of Dissent: Charting the Wave of Non-Legal Strikes in the Mid-2010s
Authors: Birelma Alpkan
Published: February 2025

In Turkey, legal strikes have been on the decline since the mid-1990s. This is a trend that has accelerated since the mid-2010s under the ruling Adalet ve Kalkınma Partisi as the government increasingly resorted to banning legal strikes against a backdrop of increasing autocratisation. Nevertheless, the country has witnessed non-legal strikes that are neither formally recognised nor documented. The data collated here through a protest event analysis methodology sheds light on these non-legal strikes, revealing a substantial, arguably historic strike wave in 2015. This study delves into the trajectory, dynamics and outcomes of this strike wave. The fact that workers managed to organise such a significant strike wave demonstrates the continuing relevance of working-class agency in today’s world. Particularly noteworthy is that it is primarily the workers themselves, without union support, who organised this strike wave. This working-class agency proved to be effective to a certain extent, demonstrating that its efforts were not in vain. Together with other social movements, the strike wave formed Turkey’s rising tide of dissent in the mid-2010s, prompting the regime to resort to further autocratisation to suppress it.
Solidarity at the intersection of data sharing and data protection: A normative analysis
Authors: Küçük Esin , Kuşkonmaz Elif Mendos
Published: February 2025

This article examines the role of solidarity in shaping evolving EU data-sharing policies, with a focus on the Data Governance Act. It seeks to demonstrate how solidarity can articulate the boundaries of the concept of ‘general interest’, guide proportionality assessments in data-sharing decisions and inform harm mitigation strategies. The analysis reveals that solidarity not only broadens the understanding of general interest by emphasizing its collective benefits but also provides safeguards for societal vulnerabilities. In cases of tension, solidarity ensures that general interests are pursued while prioritizing the need to prevent and mitigate harm. Concluding, the article argues that solidarity offers a vital framework for reconciling the competing demands of data sharing and data protection by promising a balanced approach to the EU's evolving data governance landscape.
The (slow) redress of the ‘solidarity deficit’ in the EU and the emerging principle of solidarity in EU law
Authors: Garben Sacha
Published: February 2025

This paper argues that a shift in the EU's solidarity arrangement is emerging. Although solidarity is a fundamental value of the EU project, as stated in Article 2 TEU, and in the preamble of the EU Charter where it is placed alongside human dignity, freedom and equality as the four universal values on which the Union is founded, and although the Court has held that it ‘underpins the entire legal system of the European Union’ constituting ‘its very root’, it is underdeveloped in concrete legal and political terms. This has manifested in a range of crises that the Union has become enmeshed in, and its suboptimal responses thereto. This paper flags four recent developments of change: the European Pillar of Social Rights, the NextGenEU recovery fund, the EU's response to the war in Ukraine and the CJEU's recent case law on solidarity. Indeed, there is a growing scholarship that considers that despite solidarity's somewhat ethereal nature, it is not only a theoretically important tool to understand European Union but that it is an EU legal concept gaining in importance – a general principle in the making. This paper identifies the EU Charter's preamble as the anchor for the interpretation of solidarity as a general principle of EU law.