bluuebunny/crossref_metadata_2025 huggingface dataset:
Subcritical nonlocal problems with mixed boundary conditions
Authors: Molica Bisci Giovanni , Ortega Alejandro , Vilasi Luca
Published: August 2023

By using linking and [Formula: see text]-theorems in this paper we prove the existence of multiple solutions for the following nonlocal problem with mixed Dirichlet–Neumann boundary data, [Formula: see text] where [Formula: see text], [Formula: see text], is the spectral fractional Laplacian operator, [Formula: see text], [Formula: see text], is a smooth bounded domain, [Formula: see text] is a real parameter, [Formula: see text] is the outward normal to [Formula: see text], [Formula: see text], [Formula: see text] are smooth [Formula: see text]-dimensional submanifolds of [Formula: see text] such that [Formula: see text], [Formula: see text] and [Formula: see text] is a smooth [Formula: see text]-dimensional submanifold of [Formula: see text].
3D Printing Holey-Column Metamaterial Structure Undergoing Tailorable Buckling Deformation of Local Instability
Authors: Liu Yuheng , Shu Dong-Wei , Lu Haibao , Tao Ran
Published: August 2023

3D printing metamaterial structures have attracted extensive attentions, due to their multifunctional, programmable and tailorable mechanical behaviors. Currently, the buckling behaviors of irregular and non-uniform metamaterial structures have become a prominent challenge due to their unstable deformations. In this study, we designed a 3D printed metamaterial structure with tailorable buckling behaviors by means of viscoelastic materials and holey column structure. Effects of pore shapes, porosity, rotation angles, and temperature on the buckling modes and mechanical properties of metamaterial structures have been investigated using finite element analysis and experimental tests. Furthermore, the constitutive relationships among critical buckling stress, strain, pore shape, porosity and rotation angle have been formulated to explore the design principle of local instability in holey-column metamaterial structure towards tailorable buckling modes.
GL(2) Weyl bound via a multiplicative character delta method
Authors: Leung Wing Hong
Published: August 2023

We use a trivial delta method with multiplicative characters for congruence detection to prove the Weyl bound for GL(2) in the [Formula: see text]-aspect for a holomorphic or Hecke–Maass cusp form of arbitrary level and nebentypus. This parallels the work of Aggarwal [2] in 2018, with the difference being the multiplicative character has a more natural connection to the twisted [Formula: see text]-function. This provides another viewpoint to understand and explore the trivial and other delta methods.
Convergence of improper Iwasawa continued fractions
Authors: Lukyanenko Anton , Vandehey Joseph
Published: August 2023

We prove the convergence of a wide class of continued fractions, including generalized continued fractions over quaternions and octonions. Fractional points in these systems are not bounded away from the unit sphere, so that the iteration map is not uniformly expanding. We bypass this problem by analyzing digit sequences for points that converge to the unit sphere under iteration, expanding on previous methods of Dani–Nogueira.
Plasma AGE and Oxidation Products, Renal Function, and Preeclampsia in Pregnant Women with Type 1 Diabetes: A Prospective Observational Study
Authors: Kelly Clare B. , Karanchi Harsha , Yu Jeremy Y. , Leyva Misti J. , Jenkins Alicia J. , Nankervis Alison J. , Hanssen Kristian F. , Garg Satish K. , Scardo James A. , Hammad Samar M. , Aston Christopher E. , Beisswenger Paul J. , Lyons Timothy J.
Published: August 2023

Aims. We aimed to determine whether plasma advanced glycation end products or oxidation products (AGE/oxidation-P) predict altered renal function and/or preeclampsia (PE) in pregnant women with type 1 diabetes. Methods. Prospectively, using a nested case-control design, we studied 47 pregnant women with type 1 diabetes, of whom 23 developed PE and 24 did not. Nineteen nondiabetic, normotensive pregnant women provided reference values. In plasma obtained at ~12, 22, and 32 weeks’ gestation (visits 1, 2, and 3; V1-V3), we measured five AGE products (carboxymethyllysine (CML), carboxyethyl-lysine (CEL), methylglyoxal-hydroimidazolone (MGH1), 3-deoxyglucosone hydroimidazolone (3DGH), and glyoxal-hydroimidazolone (GH1)) and four oxidation products (methionine sulfoxide (MetSO), 2-aminoadipic acid (2-AAA), 3-nitrotyrosine (3NT), and dityrosine (DT)), by liquid chromatography/mass spectroscopy. Clinical outcomes were “estimated glomerular filtration rate” (eGFR) at each visit and onset of PE. Results. In diabetic women, associations between AGE/oxidation-P and eGFR were found only in those who developed PE. In this group, CEL, MGH1, and GH1 at V2 and CML, CEL, MGH1, and GH1 at V3 were inversely associated with contemporaneous eGFR, while CEL, MGH1, 3DGH, and GH1 at V2 were inversely associated with eGFR at V3 (all

p
<
0.05

). There were no associations of plasma AGE or oxidation-P with pregnancy-related development of proteinuria or PE. Conclusions. Inverse associations of second and early third trimester plasma AGE with eGFR among type 1 diabetic women who developed PE suggest that these patients constitute a subset susceptible to AGE-mediated injury and thus to cardiorenal complications later in life. However, AGE/oxidation-P did not predict PE in type 1 diabetic women.
A Pharmacokinetic Study of Different Quercetin Formulations in Healthy Participants: A Diet‐Controlled, Crossover, Single‐ and Multiple‐Dose Pilot Study
Authors: Solnier Julia , Zhang Yiming , Roh Kyle , Kuo Yun Chai , Du Min , Wood Simon , Hardy Mary , Gahler Roland J. , Chang Chuck
Published: August 2023

This study aimed to evaluate the blood concentrations of quercetin in healthy participants after the administration of different formulations in single‐ and multiple‐dose phases. Ten healthy adults (males, 5; females, 5; age 37 ± 11 years) participated in a diet‐controlled, crossover pilot study. Participants received three different doses (250 mg, 500 mg, or 1000 mg) of quercetin aglycone orally. In the single‐dose study, blood concentrations (AUC0–24 and Cmax) of standard quercetin were compared with those of LipoMicel®—a food‐grade delivery form of quercetin. In the multiple‐dose study, blood concentrations of formulated quercetin were observed over 72 h, after repeated doses of LipoMicel (LM) treatments. The AUC0–24 ranged from 77.3 to 1128.9 ng·h/ml: LM significantly increased blood concentrations of quercetin by 7‐fold (LM 500) compared to standard quercetin, when tested at the same dose, over 24 h (p < 0.001); LM administered at a higher dose (LM 1000) achieved 15‐fold higher absorption (p < 0.001); LM tested at half a dose of standard quercetin increased concentration by approx. 3‐fold (LM 250). Quercetin blood concentrations were attained over 72 h. The major metabolites measured in the blood were methylated, sulfate, and glutathione (GSH) conjugates of quercetin. Significant differences in concentrations between quercetin conjugates (sulfate vs. methyl vs. GSH) were observed (p < 0.001). Data obtained from this study suggest that supplementation with LipoMicel® is a promising strategy to increase the absorption of quercetin and its health‐promoting effects in humans. However, due to the low sample size in this pilot study, further research is still warranted to confirm the observations in larger populations. This trial is registered with NCT05611827.
Identification of a de novo, Novel Pathogenic Variant in the Splice Region of the SOX10 Gene in an Iranian Azeri Turkish Family with Waardenburg Syndrome
Authors: Roudbari Faranak , Dallal Amandi Amir-Reza , Bonyadi Mortaza , Sadeghi Leyla , Jabbarpour Neda
Published: August 2023

Background: Waardenburg syndrome (WS) is an inherited heterogeneous auditory pigmentary syndrome, divided into at least four types and characterized by iris heterochromia, white forelock, prominent nasal root, dystopia canthorum, middle eyebrow hypertrichosis, and deafness. Pathogenic variants in the SOX10 gene have been reported to be involved in WS disease. Methods: Whole exome sequencing (WES) was conducted on a 24-year-old male, who originated from Iranian Azeri Turkish ethnic group, with symptoms of deafness and blue eyes from brown-eyed parents. Web-based tools including Mutation Taster, VarSome, SIFT, Human Splicing Finder (HSF), and I-TASSER, were used for bioinformatics analysis. To verify the WES findings, DNAs taken from the blood samples of all family members were subjected to PCR-Sanger sequencing. Results: A novel heterozygous pathogenic variant, NC_000022.11 (NM_006941):c.428+1G>T, located in the second intron of the SOX10 gene and disrupting the splicing site, was identified in the proband. Sanger sequencing was applied on the proband and his parents. The results showed that the variant was a de novo pathogenic variant with an autosomal dominant inheritance pattern. Conclusions: Identification of a novel de novo pathogenic variant, NC_000022.11 (NM_006941):c.428+1G>T, in the second intron of the SOX10 gene with autosomal dominant inheritance pattern.
A pós-verdade como paradigma argumentativo
Authors: Dominguez Michelle Gomes Alonso
Published: August 2023

Ainda sem consenso, o termo pós-verdade se relaciona estreitamente às fake news e ao discurso informativo de modo amplo, impactando, portanto, nossa comunicação nos diversos dispositivos digitais. Pensando a argumentatividade, em seu sentido amplo, como fundamento de toda troca linguageira, o estudo apresenta uma perspectiva sobre o conceito de pós-verdade e, a partir dele, reflete sobre suas consequências na construção argumentativa. Para tanto, são analisados cinco textos, dos quais três são relativos à pandemia de covid-19, veiculados nas diferentes redes sociais em abril de 2020 e identificados como “Fake” pelo Ministério da Saúde brasileiro, e dois deles circularam na propaganda eleitoral de televisão durante a campanha eleitoral à presidência do Brasil, em outubro de 2022. A análise demonstra o impacto da pós-verdade como paradigma argumentativo, inaugurando um padrão de não persuasão favorecido pela troca entre iguais. Como consequências linguístico-discursivas, são observados o apelo a implícitos (compartilhados pelos interlocutores) e a irrelevância de uma racionalidade argumentativa calcada na lógica semântica.
Compreensão do trabalho docente: um estudo de caso focado na reflexão sobre o ensino dos conhecimentos linguísticos
Authors: Bandeira Bruna
Published: August 2023

Este estudo de caso, situado no quadro teórico-epistemológico do interacionismo sociodiscursivo, objetiva testar o cofuncionamento de duas categorias de análise em pesquisas que buscam compreender o agir: ressignificações e figuras de ação. Para isso, analisa a prática de um professor de língua portuguesa do 3º ano do ensino médio a fim de mostrar como essas categorias podem contribuir para a compreensão do trabalho docente. De forma experimental, examina as ressignificações atribuídas ao atendimento da perspectiva sociointeracionista da linguagem realizadas por esse professor durante sessões de autoconfrontação simples em que refletia sobre o ensino de conhecimentos linguísticos e verifica, assim, se tais ressignificações funcionam junto às figuras de ação. Os resultados apontam para uma possível correlação entre essas duas categorias, evidenciando como conteúdo temático e marcas linguísticas podem ajudar a esclarecer o agir humano e sua apreensão.
Una secuencia didáctica para aprender a escribir. En busca de la reflexión metalingüística
Authors: Sempere Joan V.
Published: August 2023

El presente artículo tiene como objetivo presentar un modelo de secuencia didáctica fruto de la experiencia docente. El trabajo como maestro nos llevó a sucesivas adaptaciones de las propuestas de Camps y Dolz. Consideramos que cuando el trabajo se realiza con alumnos pequeños, se debe atender al conocimiento lingüístico de partida, pero también al conocimiento del mundo propio de la edad. Hemos creído necesario relacionar la secuencia con el modelo de etapas de composición de textos -planificación, textualización, revisión y corrección. Aunque dichos procedimientos son recurrentes, en este nivel educativo, el modelo elegido permite atender de manera específica las operaciones que se realizan al escribir. Pretendemos también hacer al alumnado partícipe de su propio proceso de aprendizaje y atender el desarrollo de las competencias de reflexión metalingüística e interlingüística, mediante el contraste de lenguas.
Um roteiro-memória-reflexão sobre os catorze anos de prática médica e teatral comunitária: do Hospício do Engenho de Dentro ao Teatro-Clínica Dyonises
Authors: Pordeus Vitor , Beck Thiago , Ariston Fabio , Rodrigues Nando , Guzder Jaswant
Published: August 2023

Num roteiro de escrita performativa autobiográfica, relatamos as histórias que nos levaram a desenvolver experiência de teatro e psiquiatria transcultural no mais antigo hospício público brasileiro. Essa experiência teve a contribuição de mestres da ciência e da arte brasileiras até a constituição do Teatro-Clínica DyoNises e do Hotel da Loucura, além da colaboração metodológica de autores brasileiros e internacionais.
Jacobi e seus Leitores. Uma Leitura Heterodoxa: Friedrich Nietzsche
Authors: Giacoia Junior Oswaldo
Published: August 2023

O objetivo principal deste trabalho consiste em incluir Friedrich Nietzsche no contexto de uma leitura heterodoxa do núcleo filosófico de problemas implicados na correspondência entre Friedrich Heinrich Jacobi e Moses Mendelsohn a respeito do sistema de Spinoza, fazendo-o pelo viés da correspondência mantida entre Jacobi e Fichte a respeito de panteísmo, ateísmo e niilismo.
Um diálogo entre Jacobi e Kierkegaard a partir das Proposições Preliminares sobre a Dependência e a Liberdade do homem
Authors: Paula Marcio Gimenes de
Published: August 2023

O presente artigo possui duas divisões básicas. Na primeira, almeja-se avaliar algumas das teses de Jacobi presentes na obra Proposições preliminares sobre a dependência e a liberdade do homem. Na segunda parte, o intuito é investigar a influência de Jacobi no pensamento de Kierkegaard, especialmente por meio de uma leitura selecionada de trechos dos Diários e das obras Migalhas filosóficas e Pós-escrito às migalhas filosóficas. Por fim, à guisa de conclusão, pretendemos ressaltar a importância de algumas das teses de Jacobi na obra do autor dinamarquês.
Studies on Atrial Fibrillation and Venous Thromboembolism in the Past 20 Years: A Bibliometric Analysis Via CiteSpace and VOSviewer
Authors: Miao Lina , Shi Junhe , Yu Haixu , Song Lei , Zhu Chunlin , Shi Dazhuo , Gao Jie
Published: August 2023

ABSTRACT The conjunction of atrial fibrillation (AF) and venous thromboembolism (VTE) is common in clinical practice. Over the last 2 decades, a significant number of articles (2500) have been published about AF and VTE. To effectively analyze and present these vast amounts of information, this study uses bibliometric research methods to categorize and consolidate these publications. The number of publications has increased yearly, especially since 2012. The United States was the most prolific country, with 1054 studies published. The most productive institution was McMaster University. Gregory Y.H. Lip was the most prolific author. The keyword analysis identified that the research focuses from 2003 to 2014 were factor Xa inhibitor, dabigatran etexilate, direct thrombin inhibitor, double‐blind, deep vein thrombosis, molecular weight heparin, stroke prevention, etc. From 2015 to 2016, research mainly focused on venous thromboembolism, antithrombotic therapy, anticoagulant, warfarin, atrial fibrillation, stroke, and pulmonary embolism. Studies during 2017 to 2022 focused on apixaban, direct oral anticoagulant, rivaroxaban, dabigatran, hemorrhage, edoxaban, medicine efficacy and safety, risk factors, clinical management, and vitamin K antagonists. Since 2018, novel oral anticoagulants have been the most commonly used keywords. On the whole, most studies of AF and VTE focus on pathogenesis and therapeutic drugs. The causal relationship between AF and VTE, the effectiveness and safety of novel oral anticoagulants in the treatments, the anticoagulant regimen of AF and VTE co‐disease, and the treatment regimen for vulnerable populations such as the elderly or obese people were the focus of current research and will continue to be the central point of future research.
Rapid Detection Technology Using Molecular Beacon Loop-Mediated Isothermal Amplification for Skin Infections Caused by Staphylococcus aureus
Authors: Qiu Keqing , Wu Yanqi , Fu Shangfeng , Li Xiancai , Guo Chunyan , Tu Longxiang , Shi Yan , Liu Dewu
Published: August 2023

Staphylococcus aureus (S. aureus), a Gram-positive bacterium, is often found on the skin, nasal passages, and mucous membranes of healthy individuals, where it acts as a commensal pathogen. Therefore, it is crucial to have a rapid and sensitive detection method to reduce
the spread of S. aureus infections effectively. This study developed a reliable and rapid detection protocol to identify S. aureus DNA in skin infections. The assay exhibited no cross-reactivity with four other bacterial strains and demonstrated a sensitivity of 102
CFU/mL. When tested on 24 simulated samples, the MB-LAMP assay results were consistent with those of qPCR, but with a significantly reduced testing time of approximately 30 minutes. Furthermore, this detection scheme can also rapidly detect other pathogens such as Salmonella, Monocytogenes,
and Vibrio parahaemolyticus.
Construction of Protein–Protein Interaction Networks on Capsicum Against Sepsis by Regulating of Molecular Mechanisms: Bioinformatics Approaches
Authors: Chen Xin , Zhang Ming , Yin Shuai , Gao Tianwei
Published: August 2023

We aimed to create the construction of protein–protein interaction networks for target proteins and to analyze the molecular characteristics of capsicum, screen and identify the potential targets of capsicum against sepsis using bioinformatics approaches. The potential anti-sepsis
targets of capsicum were screened by chemical protein interaction analysis and matched with the published anti-sepsis related disease targets in the Online Mendelian Inheritance in Man database (OMIM) and the Genecards Database to screen out the anti-sepsis targets of capsicum. The potential
targets of capsicum against sepsis were further identified by molecular docking server. Capsicum exhibited good medicinal properties. Overall, 14 potential targets were screened and 3453 disease targets were obtained from OMIM and Genecards databases. Subsequently, we found that there were
14 proteins that were both molecular targets and disease targets. The molecular docking server identified that the active ingredient beta-carotene had the ability to bind to 11 targeted proteins, which was a potential target of capsicum against sepsis. Capsicum can exert its therapeutic effects
by interacting with key amino acid residues of the targeted proteins. Capsicum can inhibit tissue and organ damage of sepsis by regulating CAV1 and CTNNB1, and reduce inflammatory response of sepsis by regulating MYC, VEGFA, NR3C1 and DUSP1d, and ultimately prevent and treat sepsis.
Long Non-Coding RNA Plasmacytomavariant Translocation1 as ceRNA Adsorbs miR-195 to Relieve Osteoarthritis Symptoms
Authors: Chen Xiaobo , Sun Xiaoyong , Yang Ying , Lai Xiaoyu , Tang Weidong , Wang Guangwei , Huang Hongxing , Chen Hong
Published: August 2023

This study aimed to investigate the role of the long non-coding RNA plasmacytomavariant translocation1 (LncRNA PVT1) in the development of osteoarthritis (OA). The study used mice and performed DMM surgery to establish an OA model. PVT1 and miR-195 agomir were inhibited in the knee
joints, and cartilage tissue specimens were collected for gene expression analysis, apoptotic protein detection, histopathological observation, and Mankin’s score evaluation. Enzymelinked immunosorbent assay (ELISA) was used to measure the levels of inflammatory cytokines interleukin-1β
(IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) in peripheral blood and cartilage tissues. Terminal dexynucleotidyl transferase (TdT)-mediated dUTP nick end labeling (TUNEL) staining was used to detect cartilage cell apoptosis. The results
indicated that the OA group had higher plasmacytomavariant translocation1 (PVT1) expression and lower miR-195 expression than the sham-operated group. PVT1 was found to act as a molecular sponge for miR-195 through a dual-luciferase reporter assay. Knocking down PVT1 or upregulating miR-195
significantly attenuated inflammation and apoptosis in the bone joints of OA mice. This study provides new insights into the mechanism of OA progression and suggests that regulating the PVT1-miR-195 axis may be beneficial for improving the inflammatory microenvironment of cartilage tissue
and apoptosis.
Long-Term Remission Under Combined, Systematic Therapy in Advanced or Metastatic Soft Tissue Sarcoma: A Case Report
Authors: Wang Ping , Xia Lei
Published: August 2023

Soft tissue sarcomas (STSs) are rare and heterogeneous tumors with limited treatment options for advanced stages. In this case series, we present two patients with advanced STSs who were treated with a sequential maintenance therapy strategy of chemotherapy, anti-angiogenesis, PD-1
inhibitors, and local radiotherapy. The first patient had leiomyosarcoma, and the second patient had alveolar soft part sarcoma (ASPS). Both patients had negative PD-L1 results and high tumor mutation burden (TMB). The first patient progressed after multiline therapy and radiotherapy, while
the second patient had advanced disease at diagnosis. The treatment regimen for both patients included doxorubicin and anlotinib, followed by maintenance therapy with anlotinib and tislelizumab. Both patients achieved long-term remission, with the second patient benefiting for 58 months. This
systemic treatment approach offers a new option for personalized and precise treatment of advanced STSs. The success of this approach highlights the potential of combining chemotherapy, anti-angiogenesis, PD-1 inhibitors, and local radiotherapy for the treatment of advanced STSs.
Effects of Curcumin Nanoparticles Combined with Dexmedetomidine on Cartilage Damage in Traumatic Arthritis Rats
Authors: Wang Pengfei , Liu Qingpeng
Published: August 2023

Posttraumatic osteoarthritis (PTOA) is often induced by joint sprains, fractures, and articular surface contusions. In this study, we explored the effect of curcumin nanoparticles combined with dexmedetomidine (DEX) on cartilage injury in PTOA rats. 30 adult male rats were used to construct
PTOA model by drilling intercondylar holes in the femur and assigned to blank control group, DEX group and curcumin nanoparticles+DEX group followed by analysis of articular cartilage tissue pathologies, IL-1β, TNF-α, and MMP-3 levels. The Mankin’s total score
of DEX group and curcumin nanoparticles+DEX group decreased with lower score in curcumin nanoparticles+DEX group (P <0.05). Compared with blank control group, DEX group and curcumin nanoparticles+DEX group had lower IL-1β level in joint cavity fluid and curcumin nanoparticles+DEX
group presented the lowest IL-1β, TNF-α and MMP-3 levels in joint cavity fluid. In addition, the expressions of IL-1β and other proteins in DEX group and curcumin nanoparticles+DEX group were significantly decreased with the latter showing lower expressions
(P <0.05). Curcumin nanoparticles combined with DEX can reduce the secretion of IL-1β and TNF-α and inhibit activation and expression of MMP by inhibiting NF-κB pathway, therefore exerting anti-inflammation and analgesia effects. DEX can reduce
the body’s sensitivity to adrenaline, reduce the body’s pain response, and inhibit the peripheral release of inflammatory factors. The combination of these two can help protect cartilage and prevent joint degeneration to delay the progression of PTOA.
Caregivers’ Perceptions of Child Trauma Symptomatology, Stress, and Child Abuse Disclosures
Authors: Pemberton J. Phillip , Letson Megan M. , Brink Farah , Wolf Kathryn , Kistamgari Sandhya , Michaels Nichole L.
Published: August 2023

Caregivers consider child abuse disclosures stressful life events, but research has not investigated whether this stress affects caregiver ratings of child trauma symptomatology. Secondary data from a Child Advocacy Center in the Midwestern United States between the period of January 1, 2018, and April 31, 2019, stepwise logistic regression models, and change in estimate calculations were used to assess (1) the relationship between child abuse disclosure(s) and caregiver stress and (2) the association between caregiver stress disclosure and clinically significant ratings on the Trauma Symptom Checklist for Young Children (TSCYC). While a child’s physical abuse disclosure was associated with caregiver stress and caregiver stress was significantly associated with clinically significant ratings for child depression and anger/aggression TSCYC scales, abuse disclosure did not affect the relationship between caregiver stress and TSCYC scale ratings. Moving forward, caregiver-reported stress should be considered when utilizing caregiver-completed child trauma symptom screens.
Cascade of Care in the Legal System: Best Practices and Goals for Agencies Providing Care to Patients Concurrently Navigating Substance Use Disorders and Criminal Legal Involvement
Authors: Clark Kendra J. , Vechinski Jessica , Molfenter Todd , Taxman Faye S.
Published: August 2023

Fewer than 1% of United States’ largest corrections facilities allow access to MOUD. The cascade of care is an organizing framework that quantifies treatment processes within and across systems of care ranging from screening to treatment discharge. This study highlights best practices for the implementation of MOUD across the cascade of care, addressing unique characteristics of legal settings and individuals within them. After reviewing best-practices for MOUD implementation in legal settings and examining jail and community provider’s use of and goals toward improving these practices, this study concludes that despite interest from agencies to improve care considerable variation remains in treatment availability between agencies and within agencies at different stages of incarceration. Seamless systems of care require multiagency collaboration, staff and provider competency, and patient awareness of MOUD. These strategies will decrease punishment-oriented ideologies surrounding MOUD application in justice settings and improve access to resources that remove barriers to care.
The evolving unity of structural mechanics in stretch-dominant textile architectures
Authors: Rawal Amit
Published: August 2023

A library of textile materials with diverse length scales encompasses helically arranged fibril assemblies, filament yarns, nonwovens to braids, which share structural commonalities and mechanics stemming from constituent entities while subjected to stretching. Herein, a generalized framework in the form of an analytical model for predicting the stress-strain behavior of textile materials that share structural similarities based on stretch-induced constituent entities has been proposed. A simple “Poisson's ratio” based criterion has also been devised to categorize the stretching-dominated or bending-dominated during tensile or compression deformation.
Asymmetrical Influences of Service Robots’ Perceived Performance on Overall Customer Satisfaction: An Empirical Investigation Leveraging Online Reviews
Authors: Borghi Matteo , Mariani Marcello M.
Published: August 2023

Service scholars seem to have empirically overlooked the impact of service robots in the overall customer evaluation of tourism services. This study addresses this gap by leveraging three-factor theory and electronic Word-Of-Mouth data to assess human-robot interaction’ influence on customer satisfaction. Text analytics are deployed alongside a penalty-reward contrast technique on almost 70,000 online reviews spanning 44 hotels worldwide that incorporated service robots into their operations. Customer satisfaction with hospitality services is significantly increased by positive service robots’ performance, while no significant effect is associated with negative service robots’ performance. The traveler type does not moderate the relationship between service robots’ performance and customer satisfaction. These findings, confirmed through Propensity Score Matching, reveal that service robots constitute an “excitement factor” in hospitality service offerings, thus providing a strong incentive for their integration into the workforce. Policymakers are urged to proactively facilitate the transition to a more automated service economy.
A data-driven soft-sensing approach using probabilistic latent variable model with functional data framework
Authors: Tan Xiaoying , Guo Wei , Liu Ranran , Pan Tianhong
Published: August 2023

Functional principal component analysis (FPCA) and functional partial least squares (FPLS) are two mainstream functional data analysis (FDA) methods, which have been commonly used to extract deep information hidden in the original data space. However, the process data always contain random noise, which affects the performance of FDA models. To overcome this issue, two functional probabilistic latent variable models (FPLVMs), including functional probabilistic principal component analysis (FPPCA) and functional probabilistic partial least squares (FPPLS) are proposed in this work. First, the process data are converted into functional data using the FDA. Subsequently, a log-likelihood function considering the noise factor and functional latent variables is designed. Finally, the regression model parameters are estimated using an expectation–maximisation algorithm. In contrast to FPPCA, FPPLS decomposes the process data and the key variable with constrained latent variables, which is similar to the partial least squares (PLS) and the principal component analysis (PCA). Moreover, the degeneration mechanism from FPLVMs into probabilistic latent variable models and latent variable models is discussed. An adaptive strategy with functional covariance is used to satisfy the online predictive capabilities of the model. Finally, the proposed approach is validated using a numerical case, the Tennessee Eastman process and an industrial o-xylene distillation column for evaluation.
Secure iterative interval estimation method for cyber-physical systems subject to stealthy deception attacks
Authors: Zhang Tu , Zhang Guobao , Huang Yongming
Published: August 2023

This paper studies a secure iterative interval estimation approach for cyber-physical systems subject to stealthy deception attacks. Under the hypothesis that the system is accessed by a stealthy attack, an iteration scheme integrating the T-N-L observer framework is employed to reconstruct the system state. With the help of a structure separation method, a sufficient condition in terms of linear matrix inequality is provided to obtain convergent observation errors under deception attacks. Resorting to the reachability analysis, a secure state interval is built by means of the analyzed attack bounds and the observation error interval. Simulation studies verify the effectiveness of the proposed method for attack and attack-free cases.
What Does “Resistance” Actually Look Like? The Respecification of Resistance as an Interactional Accomplishment
Authors: Humă Bogdana , Joyce Jack B. , Raymond Geoffrey
Published: August 2023

In this introductory article to the special issue on Resistance in Talk-in-Interaction, we review the vast body of research that has respecified resistance by investigating it as and when it occurs in real-life encounters. Using methodological approaches such as ethnomethodology, conversation analysis, and discursive psychology, studies of resistance “in the wild” treat social interaction as a sequentially organized, joint enterprise. As a result, resistance emerges as the alternative to cooperation and therefore, on each occasion, resistant actions are designed to deal with the sequential and moral accountabilities that arise from the specifics of the situation. By documenting the wide array of linguistic, prosodic, sequential, and embodied resources that individuals use to resist the requirements set by interlocutors’ prior turns, this article provides the first comprehensive overview of existing research on resistance as an interactional accomplishment.
Isolated pancreatic tuberculosis masquerading as malignancy in an immunocompetent host: a case report and review of the literature
Authors: Gu Yangjun , Xiao Min , Wan Zhenmiao , Li Qiyong
Published: August 2023

A 41-year-old man was admitted to our department with a 7-day history of jaundice of the skin. He was misdiagnosed with carcinoma because imaging tests showed a space-occupying lesion in the pancreatic head, and laboratory examinations showed elevated liver enzymes, and elevated serum bilirubin, alpha-fetoprotein, carbohydrate antigen 19-9, and ferroprotein levels. However, there was slight calcification in the lesion and a subsequent T-Spot test result was positive. The patient then underwent endoscopic retrograde cholangiopancreatography for biopsy and bile drainage. Histologically, the pancreatic mass showed granulomatosis, and the pathologic diagnosis of the isolated pancreatic neoplasm was tuberculosis. The patient accordingly received anti-tuberculosis agents, resulting in a significant decrease in the size of the pancreatic mass. The patient recovered well. Pancreatic tuberculosis can masquerade as malignancy; however, careful attention to a differential diagnosis can prevent the need for laparotomy.
Histologic characterization of the major duodenal papilla and association with concurrent biliary, pancreatic, and intestinal pathology in cats
Authors: Schreeg Megan E. , Cullen John M. , Robertson James , Gookin Jody L.
Published: August 2023

Conjoining of the major pancreatic duct and common bile duct at the major duodenal papilla (MDP) is suspected to predispose cats to the clinical syndrome of “triaditis.” However, microanatomy of the MDP or presence of lesions at the MDP has not been assessed in cats with or without triaditis. The aims of this study were to characterize feline MDP histomorphology and to identify associations between MDP anatomy/disease and the presence of biliary, pancreatic, or intestinal inflammation or neoplasia. Histologic assessment was prospectively performed on the MDP, duodenum, jejunum, ileum, liver, and pancreas from 124 client-owned cats undergoing postmortem examination. The majority of cats (104/124, 84%) had a complex ductular network at the MDP, with no distinction between pancreatic and common bile ducts. Lymphoid aggregates at the MDP were common (63/124, 51%). Inflammation of the MDP (MDPitis) was present in 35 of 124 cats (28%) and was often concurrent with cholangitis, pancreatitis, or enteritis (32/35, 91%), but was only associated with enteritis (19/35, 54%, P < .05). Triaditis was less common (19/124, 15%), but was associated with both conjoined MDP anatomy (19/19, 100%, P < .05) and MDPitis (12/19, 63%, P < .05). Neoplasia was present in 37 of 124 cats (29%), with lymphoma (28/37, 78%) predominating. Enteropathy-associated T-cell lymphoma type 2 (EATL2) was most common ( n = 16/37, 43%) and was associated with triaditis and MDPitis ( P < .05). These findings suggest that anatomy, immune activation, and/or inflammation of the MDP may play a role in the pathogenesis of triaditis. Further studies are needed to elucidate the relationships between triaditis, MDPitis, and EATL2.
Propensity score weighting methods for causal subgroup analysis with time-to-event outcomes
Authors: Yang Siyun , Zhou Ruiwen , Li Fan , Thomas Laine E
Published: August 2023

Evaluating causal effects of an intervention in pre-specified subgroups is a standard goal in comparative effectiveness research. Despite recent advancements in causal subgroup analysis, research on time-to-event outcomes has been lacking. This article investigates the propensity score weighting method for causal subgroup survival analysis. We introduce two causal estimands, the subgroup marginal hazard ratio and subgroup restricted average causal effect, and provide corresponding propensity score weighting estimators. We analytically established that the bias of subgroup-restricted average causal effect is determined by subgroup covariate balance. Using extensive simulations, we compare the performance of various combinations of propensity score models (logistic regression, random forests, least absolute shrinkage and selection operator, and generalized boosted models) and weighting schemes (inverse probability weighting, and overlap weighting) for estimating the causal estimands. We find that the logistic model with subgroup-covariate interactions selected by least absolute shrinkage and selection operator consistently outperforms other propensity score models. Also, overlap weighting generally outperforms inverse probability weighting in terms of balance, bias and variance, and the advantage is particularly pronounced in small subgroups and/or in the presence of poor overlap. We applied the methods to the observational Comparing Options for Management: PAtient-centered REsults for Uterine Fibroids study to evaluate the causal effects of myomectomy versus hysterectomy on the time to disease recurrence in a number of pre-specified subgroups of patients with uterine fibroids.
Restricted mean survival time to estimate an intervention effect in a cluster randomized trial
Authors: Vilain–Abraham Floriane Le , Tavernier Elsa , Dantan Etienne , Desmée Solène , Caille Agnès
Published: August 2023

For time-to-event outcomes, the difference in restricted mean survival time is a measure of the intervention effect, an alternative to the hazard ratio, corresponding to the expected survival duration gain due to the intervention up to a predefined time t*. We extended two existing approaches of restricted mean survival time estimation for independent data to clustered data in the framework of cluster randomized trials: one based on the direct integration of Kaplan-Meier curves and the other based on pseudo-values regression. Then, we conducted a simulation study to assess and compare the statistical performance of the proposed methods, varying the number and size of clusters, the degree of clustering, and the magnitude of the intervention effect under proportional and non-proportional hazards assumption. We found that the extended methods well estimated the variance and controlled the type I error if there was a sufficient number of clusters (≥ 50) under both proportional and non-proportional hazards assumption. For cluster randomized trials with a limited number of clusters (< 50), a permutation test for pseudo-values regression was implemented and corrected the type I error. We also provided a procedure to estimate permutation-based confidence intervals which produced adequate coverage. All the extended methods performed similarly, but the pseudo-values regression offered the possibility to adjust for covariates. Finally, we illustrated each considered method with a cluster randomized trial evaluating the effectiveness of an asthma-control education program.
Study of Pulse Oximetry Trends in Normal Newborn
Authors: Reddy S. Chandramohan , Dwivedi Rashmi , sharma Rajeev , Bansod Nilesh
Published: August 2023

Objectives

To study oxygen saturation trends in newborns at birth and up to 15 min of life.

Material and methods

A prospective observational study was conducted on 300 healthy term and preterm newborns (those who did not require supplemental oxygen) delivered by SVD and LSCS at a tertiary care Centre. The convenience sampling technique was used based on the fact about 3–4 deliveries take place daily, and only a proportion of these met the study inclusion criteria.

Results

At 5 min of life, 0.7% of male newborns and 0.63% of female newborns had SpO2 levels above 90%. All male and female newborns reached SpO2 > 90% at 15 min of life, compared to 78.87% of male newborns and 71.52% of female newborns at 10 min of life. Male and female newborns revealed no statistically significant difference in saturations and in time to reach SpO2 > 90% at 5, 10, and 15 min of life. Newborns born via LSCS had lower SpO2 than newborns delivered by SVD in 5, 10, and 15 min, respectively, and this difference was statistically significant ( p < 0.0001).

Conclusion

The relationship between SpO2 and gender was not statistically different. Compared to newborns delivered by SVD, SpO2 was significantly lower in newborns born via LSCS and required less time to reach >90% saturation.
Artificial Neural Network Analysis of Determinants of Tacrolimus Pharmacokinetics in Liver Transplant Recipients
Authors: Du Yue , Zhang Yundi , Yang Zhiyan , Li Yue , Wang Xinyu , Li Ziqiang , Ren Lei , Li Yan
Published: August 2023

Background

The efficacy and toxicity of tacrolimus are closely related to its trough blood concentrations. Identifying the influencing factors of pharmacokinetics of tacrolimus in the early postoperative period is conducive to the optimization of the individualized tacrolimus administration protocol and to help liver transplant (LT) recipients achieve the target blood concentrations.

Objective

This study aimed to develop an artificial neural network (ANN) for predicting the blood concentration of tacrolimus soon after liver transplantation and for identifying determinants of the concentration based on Shapley additive explanation (SHAP).

Methods

In this retrospective study, we enrolled 31 recipients who were first treated with liver transplantation from the Department of Liver Transplantation and Hepatic Surgery, the First Affiliated Hospital of Shandong First Medical University (Shandong Provincial Qianfoshan Hospital) from November 2020 to May 2021. The basic information, biochemical indexes, use of concomitant drugs, and genetic factors of organ donors and recipients were used for the ANN model inputs, and the output was the steady-state trough concentration (C0) of tacrolimus after oral administration in LT recipients. The ANN model was established to predict C0 of tacrolimus, SHAP was applied to the trained model, and the SHAP value of each input was calculated to analyze quantitatively the influencing factors for the output C0.

Results

A back-propagation ANN model with 3 hidden layers was established using deep learning. The mean prediction error was 0.27 ± 0.75 ng/mL; mean absolute error, 0.60 ± 0.52 ng/mL; correlation coefficient between predicted and actual C0 values, 0.9677; and absolute prediction error of all blood concentrations obtained by the ANN model, ≤3.0 ng/mL. The results indicated that the following factors had the most significant effect on C0: age, daily drug dose, genotype at CYP3A5 polymorphism rs776746 in both recipient and donor, and concomitant use of caspofungin. The predicted C0 value of tacrolimus in LT recipients increased in a dose-dependent manner when the daily dose exceeded 3 mg, whereas it decreased with age when LT recipients were older than 48 years. The predicted C0 was higher when recipients and donors had the genotype CYP3A5*3*3 than when they had the genotype CYP3A5*1. The predicted C0 value also increased with the use of caspofungin or Wuzhi capsule.

Conclusion and relevance

The established ANN model can be used to predict the C0 value of tacrolimus in LT recipients with high accuracy and good predictive ability, serving as a reference for personalized treatment in the early stage after liver transplantation.
Comparison Between Manual and Automated Assessment of Ki-67 in Breast Carcinoma: Test of a Simple Method in Daily Practice
Authors: Catteau Xavier , Zindy Egor , Bouri Sarah , Noël Jean-Christophe , Salmon Isabelle , Decaestecker Christine
Published: August 2023

Background

In the era of “precision medicine,” the availability of high-quality tumor biomarker tests is critical and tumor proliferation evaluated by Ki-67 antibody is one of the most important prognostic factors in breast cancer. But the evaluation of Ki-67 index has been shown to suffer from some interobserver variability. The goal of the study is to develop an easy, automated, and reliable Ki-67 assessment approach for invasive breast carcinoma in routine practice.

Patients and Methods

A total of 151 biopsies of invasive breast carcinoma were analyzed. The Ki-67 index was evaluated by 2 pathologists with MIB-1 antibody as a global tumor index and also in a hotspot. These 2 areas were also analyzed by digital image analysis (DIA).

Results

For Ki-67 index assessment, in the global and hotspot tumor area, the concordances were very good between DIA and pathologists when DIA focused on the annotations made by pathologist (0.73 and 0.83, respectively). However, this was definitely not the case when DIA was not constrained within the pathologist's annotations and automatically established its global or hotspot area in the whole tissue sample (concordance correlation coefficients between 0.28 and 0.58).

Conclusions

The DIA technique demonstrated a meaningful concordance with the indices evaluated by pathologists when the tumor area is previously identified by a pathologist. In contrast, basing Ki-67 assessment on automatic tissue detection was not satisfactory and provided bad concordance results. A representative tumoral zone must therefore be manually selected prior to the measurement made by the DIA.
From Isolated to Resilient: Adolescents’ Experiences in the Early Stages of COVID-19
Authors: Hilliard Elizabeth , Twiss Brittany
Published: August 2023

Isolation, quarantine, and fear of the Coronavirus have led to increases in mental health concerns in adults and teens. While research has begun documenting the increased rates of mental illness resulting from the pandemic, there has been little in-depth exploration of how teens from diverse backgrounds are experiencing the COVID-19 pandemic. The present study was a focus group conducted with 5 TRIO Upward Bound high school students in a midwestern US state to explore how COVID-19 has impacted them and their communities. Results showed that while these teens reported feeling developmentally impeded and unable to follow social distancing guidelines, they also reported finding ways to cope. These results are important in understanding how teens from diverse backgrounds build resiliency, and how they face challenges during social isolation. Future research should involve longitudinal designs that follow teens into their adult lives to determine how development and resilience continue to change over time.
The South African Flag Sign: An Electrocardiographic Flag for All Coronary Territories?
Authors: Swarath Steven , Maharaj Nicole , Hall Andrew , Frederick Jean Marie , Seecheran Rajeev , Seecheran Valmiki , Seecheran Naveen Anand
Published: August 2023

The South African flag sign (SAFS) is an acute, dynamic electrocardiographic (ECG) finding typically associated with first diagonal (D1) artery occlusion. We report the case of a 47-year-old woman who exhibited this pattern but subsequently revealed the dreaded “widow-maker” lesion (100% occluded proximal left anterior descending [LAD] artery) and severe multivessel disease (90% stenosis of the posterior left ventricular [PLV] artery and 80% stenosis of the left circumflex artery [LCx]).