bluuebunny/crossref_metadata_2025 huggingface dataset:
Long-term follow-up of the RESONATE phase 3 trial of ibrutinib vs ofatumumab
Authors: Byrd John C. , Hillmen Peter , O’Brien Susan , Barrientos Jacqueline C. , Reddy Nishitha M. , Coutre Steven , Tam Constantine S. , Mulligan Stephen P. , Jaeger Ulrich , Barr Paul M. , Furman Richard R. , Kipps Thomas J. , Thornton Patrick , Moreno Carol , Montillo Marco , Pagel John M. , Burger Jan A. , Woyach Jennifer A. , Dai Sandra , Vezan Remus , James Danelle F. , Brown Jennifer R.
Published: March 2019

Ibrutinib, a once-daily oral inhibitor of Bruton tyrosine kinase, has greatly improved outcomes for patients with chronic lymphocytic leukemia (CLL). The phase 3 RESONATE trial, which compared single-agent ibrutinib to ofatumumab in high-risk, relapsed patients with CLL, provided support for approval of ibrutinib in the United States and Europe. We describe long-term follow-up of patients treated in RESONATE, where continued superiority of progression-free survival (PFS) (hazard ratio [HR], 0.133; 95% confidence interval [CI], 0.099-0.178) was observed. Overall survival benefit continues (HR, 0.591; 95% CI, 0.378-0.926), although with decreased magnitude relative to that seen before crossover to ibrutinib was implemented for patients on ofatumumab (HR, 0.426; 95% CI, 0.220-0.823). Notably, overall response to ibrutinib increased over time, with 91% of patients attaining a response. The PFS benefit with ibrutinib was independent of baseline risk factors, although patients with ≥2 prior therapies had shorter PFS than those with <2 prior therapies, and the presence of TP53 or SF3B1 mutations showed a trend toward shorter PFS vs without these factors. Median duration of ibrutinib was 41 months, with 46% remaining on treatment at a median follow-up of 44 months. Grade ≥3 adverse events generally decreased over time, causing only a small proportion of patients to cease therapy. Ibrutinib was discontinued due to progressive disease in 27% of patients. This long-term study provides support for sustained efficacy and safety of ibrutinib in relapsed/refractory CLL and consideration of study provisions that allow crossover to investigational therapy when benefit has been clearly demonstrated. This trial was registered at www.clinicaltrials.gov as #NCT01578707.
Upregulation of MUC5AC production and deposition of LEWIS determinants by HELICOBACTER PYLORI facilitate gastric tissue colonization and the maintenance of infection
Authors: Gonciarz Weronika , Walencka Maria , Moran Anthony P. , Hinc Krzysztof , Obuchowski Michał , Chmiela Magdalena
Published: March 2019

Background

Helicobacter pylori bacteria colonize human gastric mucosa, cause chronic inflammation, peptic ulcers and gastric cancer. Colonization is mediated by H. pylori adhesins, which preferentially bind mucin 5 (MUC5AC) and Lewis (Le) determinants. The aim of this study was to evaluate the influence of H. pylori and their components on MUC5AC production and deposition of LeX/LeY in gastric epithelial cells in relation to bacterial adhesion using Caviae porcellus primary gastric epithelial cells and an in vivo model of experimental H. pylori infection in these animals.

Methods

MUCA5C and LeX/LeY were induced in vitro by live H. pylori reference strain CCUG 17874 (2 × 107 CFU/ml), H. pylori glycine acid extract (GE), 10 μg/ml; cytotoxin associated gene A (CagA) protein, 1 μl/ml; UreA urease subunit, 5 μg/ml; lipopolysaccharide (LPS) 25 ng/ml and imaged by fluorescence microscopy after anti-MUC5AC or anti-LeX/LeY FITC antibody staining. Bacterial adhesion was imaged by using anti-H. pylori FITC antibodies. The animals were inoculated per os with H. pylori (3 times in 2 days intervals, 1 × 1010 CFU/ml). After 7 or 28 days an infection and inflammation were assessed by histological, serological and molecular methods. Gastric tissue sections of infected and control animals were screend for MUCA5C and LeX, and H. pylori adhesion as above.

Results

MUC5AC production and deposition of Lewis determinants, especially LeX were upregulated in the milieu of live H. pylori as well as GE, CagA, UreA or LPS in vitro and in vivo during infection, more effectively in the acute (7 days) than in the chronic (28 days) phase of infection. This was related to enhanced adhesion of H. pylori, which was abrogated by anti-MUC5AC and anti-LeX or anti-LeY antibody treatment.

Conclusions

Modulation of MUCA5C production and LeX/LeY deposition in the gastric mucosa by H. pylori can significantly increase gastric tissue colonization during H. pylori infection.
Analytical Modeling of Moderately Ductile RC Frame Structures for Seismic Performance Evaluation Using PERFORM-3D
Authors: Al Mamuna Abdullah , Saatcioglu Murat
Published: March 2019

Performance-based vulnerability assessment of buildings requires dynamic inelastic analysis, which cannot be conducted without reliable analytical models. An important aspect of analytical building models involves hysteretic modeling of force-deformation relationships. PERFORM-3D software was used to generate fragility curves for moderately ductile buildings in Eastern Canada using hysteretic models with different features reflecting the recommendations of different North American standards. Two-story and five-story reinforced concrete (RC) frame buildings were considered for this purpose. The parameters that define rotational limits, as specified in ASCE 41-13 and ACI 369R-11 as well as the National Building Code of Canada (NBCC), were assessed. The results indicate that the variations in modeling parameters did not result in significant differences in fragility response at immediate occupancy and life safety performance levels, whereas the fragilities at the collapse performance level were affected. The probability of exceeding collapse prevention in buildings modeled as per NBCC was higher than those modeled using the ASCE 41-13 and ACI 369R-11 requirements.
Differences in degree of lesion enhancement on CEM between ILC and IDC
Authors: van Nijnatten Thiemo JA , Jochelson Maxine S , Pinker Katja , Keating Delia M , Sung Janice S , Morrow Monica , Smidt Marjolein L , Lobbes Marc BI
Published: March 2019

Objective:

To investigate differences in the degree of enhancement on contrast-enhanced mammography (CEM) between patients with invasive lobular (ILC) and infiltrating ductal carcinoma (IDC) not otherwise specified.

Methods and materials:

Between 2010 and 2017, all patients diagnosed with ILC and who underwent CEM were included for this dual center study. Twenty-two patients with IDC, matched by size, were identified for comparison. Three independent readers, blinded for histopathology results, re-evaluated all CEM exams to determine degree of lesion enhancement according to a previously defined scoring scale ranging from minimal to strong enhancement. Interobserver agreement among the three readers was calculated by quadratic weighted κ coefficient.

Results:

44 patients were included: 22 patients with ILC and 22 patients with IDC. There were no significant differences in age, mean tumor size, tumor grade or receptor status between the two subgroups. Degree of lesion enhancement on CEM was more often considered weak in case of ILC compared to IDC according to two out of three readers (31.8% vs 4.5 %, p = 0.045 and 22.7 vs 4.5 %, p = 0.185). All other lesions showed moderate or strong enhancement. Interobserver agreement between the three independent readers was good (κ = 0.72).

Conclusion:

In patients with ILC, degree of lesion enhancement on CEM appears to be more often weak than in infiltrating ductal carcinoma not otherwise specified. Radiologists should be aware that weakly enhancing lesions may in fact be malignant and particularly invasive lobular cancers.

Advances in knowledge:

Three independent readers evaluated 44 CEM cases with ILC or IDC. Degree of lesion enhancement seems more often weak in case of ILC. Radiologists should be aware of ILC in case of weak CEM enhancement.
Neuroendoscopic minimally invasive surgery and small bone window craniotomy hematoma clearance in the treatment of hypertensive cerebral hemorrhage
Authors: Gui Chengjia , Gao Yikuan , Hu Dan , Yang Xinyu
Published: March 2019

Objective: To analyze the effects of neuroendoscopic minimally invasive surgery and small bone window craniotomy hematoma clearance through comparing clinical indicators of the two operation modes and to provide a reference for selection of proper minimally invasive surgery.

Methods: One hundred and twenty-six patients with hypertensive cerebral hemorrhage who received diagnosis and treatment in our hospital between December 2015 and December 2017 were selected and grouped into an observation group (n=63) and a control group (n=63) using random number table. Patients in the observation group were treated by neuroendoscopic surgery, while patients in the control group were treated by small bone window craniotomy. The surgical condition, clinical effect and prognosis of the two groups were analyzed and compared.

Results: Patients in the observation group completed surgery in a shorter time and bled less during operation compared to the control group, and the hematoma clearance rate of the observation group was obviously higher than that of the control group; the differences had statistical significance (P<0.05). The nerve deficiency scale (NDS) scores of the two groups at the postoperative 3rd month were lower than those before surgery (P<0.05), and the activity of daily life (ADL) score at the postoperative 3rd month was higher than that before surgery (P<0.05). The observation group had lower NDS score and higher ADL score compared to the control group, and the differences had statistical significance (P<0.05). The incidence of complications of the observation group was lower than that of the control group after surgery, and the rate of favourable prognosis of the observation group was higher than that of the control group at the postoperative 3rd month (P<0.05).

Conclusion: Neuroendoscopic surgery is more effective and safe, causes less bleeding and has better prognosis and nerve function recovery compared to small bone window craniotomy in the treatment of hypertensive cerebral hemorrhage.

How to cite this:Gui C, Gao Y, Hu D, Yang X. Neuroendoscopic minimally invasive surgery and small bone window craniotomy hematoma clearance in the treatment of hypertensive cerebral hemorrhage. Pak J Med Sci. 2019;35(2):377-382. doi: https://doi.org/10.12669/pjms.35.2.463

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Σχολικό κλίμα, συναισθηματική νοημοσύνη και ψυχική ανθεκτικότητα των εκπαιδευτικών
Authors: ΒΑΣΙΟΥ ΑΙΚΑΤΕΡΙΝΗ , ΙΟΡΔΑΝΙΔΗΣ ΓΕΩΡΓΙΟΣ , ΝΕΣΤΟΡΑ ΙΟΥΛΙΑ
Published: March 2019

Λαμβάνοντας υπόψη ότι το σχολικό κλίμα αναφέρεται στην ποιότητα της σχολικής ζωής (Brookover, 1985) και ότι η συναισθηματική νοημοσύνη έχει επιπτώσεις στις εργασιακές τους εμπειρίες των εκπαιδευτικών (Kafetsios&Zampetakis, 2008· Kafetsios&Loumakou, 2007· Kafetsios, Nezlek&Vassiou, 2011), θα ήταν σημαντικό τα σχολεία να δώσουν έμφαση σε παράγοντες του σχολικού κλίματος και σε ικανότητες της συναισθηματικής νοημοσύνης των εκπαιδευτικών που ενδεχομένως να επηρεάζουν την ψυχική τους ανθεκτικότητα, δηλαδή την ικανότητα να ξεπερνούν τα προβλήματα που προκύπτουν στην εργασία τους (Cicchetti, 2003·Luthar, 2006·Masten, 2001·Rutter, 2000). Η έρευνα μελέτησε την επίδραση του σχολικού κλίματος και της συναισθηματικής νοημοσύνης των εκπαιδευτικών στην ψυχική τους ανθεκτικότητα. 168 εκπαιδευτικοίΑ/θμιαςΕκπ/σηςσυμπλήρωσαν τις κλίμακες: Revised-SchoolLevelEnvironmentQuestionnaire (R-SLEQ·Johnson, Stevens&Zvoch, 2007), WongLawEmotionalIntelligenceScale (WLEIS, Wong&Law, 2002) καιResilienceScale (Wagnild&Young, 1993). Τα αποτελέσματα έδειξαν ότι οι διαστάσεις του σχολικού κλίματος και της συναισθηματικής νοημοσύνηςσυσχετίζονται θετικά με την ψυχική ανθεκτικότητα των εκπαιδευτικών. Τα αποτελέσματα μπορούν να εφαρμοστούν στη διαδικασία επιμόρφωσης των διευθυντών σχολικών μονάδων, με στόχο τηδημιουργία θετικού σχολικού κλίματος, καθώς και σε προγράμματα κοινωνικής και συναισθηματικής μάθησης στη διαδικασία εκπαίδευσης των εκπαιδευτικών.
Φορείς Περιβαλλοντικής Εκπαίδευσης
Authors: ΓΚΑΪΤΑΤΖΗ ΔΕΣΠΟΙΝΑ
Published: March 2019

Στο πλαίσιο της Περιβαλλοντικής Εκπαίδευσης σημαντικό ρόλο διαδραματίζουν Φορείς τόσο στην τυπική όσο και στη μη τυπική εκπαίδευση.Σκοπός της παρούσας εργασίας είναι να αναδείξει το έργο των Φορέων της Π.Ε. στην αναδιαμόρφωση της περιβαλλοντικής αγωγής των μαθητών καθώς και των εκπαιδευτικών με την ενίσχυση της βιωματικής διδασκαλίας (Στυλιανίδης, 2011: 349).Ειδικότερα, για την επίτευξη του παραπάνω σκοπού αρμόδιοι οργανισμοί είναι οι σχολικές μονάδες, τα Γραφεία Εκπαίδευσης για την Αειφορία (Γ.Ε.Α.), τα Κέντρα Περιβαλλοντικής Εκπαίδευσης (Κ.Π.Ε.) και ο κεντρικός φορέας διαχείρισης και υποστήριξης (Στυλιανίδης, 2011: 354).Η συγκρότηση των Φορέων της Π.Ε. εξυπηρετεί στην οργάνωση και στη στήριξη των σχολικών δραστηριοτήτων και των προγραμμάτων της Π.Ε. Με τις δράσεις αυτές επιτυγχάνεται η μεταβίβαση κατάλληλων και επαρκών γνώσεων καθώς και μεθοδολογικών εργαλείων στα σχολεία για την ανάγνωση, ανάλυση και μελέτη του περιβάλλοντος και των προβλημάτων του (Καλαϊτζίδης, Ουζούνης, 2000: 65).Απώτερος σκοπός όλων των παραπάνω είναι οι εμπλεκόμενοι στη μάθηση να αποκτήσουν οικολογική γνώση, να συνειδητοποιήσουν τα περιβαλλοντικά προβλήματα και την περιβαλλοντική υποβάθμιση και να συμβάλουν μέσω της ατομικής και συλλογικής τους εργασίας στην επίτευξη και τη διατήρηση μιας δυναμικής ισορροπίας μεταξύ της ποιότητας ζωής και της ποιότητας του περιβάλλοντος (Hungerford, Peyton, Wilke, 1980: 42).
Διερεύνηση των στάσεων νηπιαγωγών, κοινωνικών λειτουργών και γονέων αναφορικά με τα δικαιώματα συμμετοχής των παιδιών προσχολικής ηλικίας.
Authors: ΣΚΟΥΦΟΥ ΑΣΠΑΣΙΑ , ΧΑΡΙΤΑΚΗ ΓΑΡΥΦΑΛΙΑ
Published: March 2019

Η παρούσα εργασία πραγματεύεται με τα δικαιώματα συμμετοχής των παιδιών προσχολικής ηλικίας. Σκοπός της, αποτελεί αφενός η μελέτη των στάσεων των κοινωνικών λειτουργών, των νηπιαγωγών και των γονέων παιδιών της συγκεκριμένης ηλικιακής ομάδας σχετικά με τα δικαιώματα συμμετοχής των τελευταίων και αφετέρου η διερεύνηση των πρακτικών, που οι παιδαγωγοί χρησιμοποιούν κατά τη μαθησιακή διαδικασία. Προκειμένου να εξασφαλιστεί η εγκυρότητα και η αξιοπιστία, στα πλαίσια της έρευνας, θεωρήθηκε κατάλληλη η τριγωνοποίηση της ποσοτικής και ποιοτικής μεθόδου. Ειδικότερα επιλέχθηκε ένα εργαλείο της ποσοτικής προσέγγισης, το ερωτηματολόγιο και ένα εργαλείο της ποιοτικής, η συνέντευξη. Σύμφωνα με τα αποτελέσματα, που προέκυψαν, οι νηπιαγωγοί γνωρίζουν σε αρκετά ικανοποιητικό βαθμό τα δικαιώματα συμμετοχής των παιδιών και τα υλοποιούν κατά τη διάρκεια της εκπαιδευτικής διαδικασίας στο βαθμό, που το αναλυτικό πρόγραμμα σπουδών (Α.Π.Σ), τους το επιτρέπει. Επίσης, οι κοινωνικοί λειτουργοί, έχοντας λάβει την κατάλληλη επιστημονική κατάρτιση,έχουν γνώση των δικαιωμάτων συμμετοχής των παιδιών και τον τρόπο υλοποίησης τους σε οικογενειακό και επαγγελματικό επίπεδο. Από τη συνέντευξη των γονέων παιδιών προσχολικής ηλικίας, προέκυψε ότι γνωρίζουν σε ικανοποιητικό βαθμό την κατηγορία των συγκεκριμένων δικαιωμάτων και ιδιαίτερα οι γονείς, που ασχολούνται με τον παιδαγωγικό τομέα.
Η αφοσίωση των εκπαιδευτικών ειδικής αγωγής στο σχολείο που υπηρετούν: Η υποστηρικτική ηγετική συμπεριφορά του διευθυντή του σχολείου, η επαγγελματική ικανοποίηση και το συναίσθημα στο χώρο εργασίας ως προβλεπτικοί παράγοντες
Authors: ΣΤΑΥΡΟΠΟΥΛΟΣ ΒΑΣΙΛΕΙΟΣ
Published: March 2019

Η αφοσίωση των  εκπαιδευτικών αποτελεί σημαντικό εργασιακό παράγοντα, καθόσον σχετίζεται τόσο με  με την απόδοσή τους στο πλαίσιο άσκησης του έργου που επιτελούν όσο και με την επίδοση των μαθητών τους. Στην περίπτωση των εκπαιδευτικών ειδικής αγωγής η αφοσίωση αυτή αξιολογείται θετικά διότι επιδίδονται στο απαιτητικό έργο της εκπαίδευσης των μαθητών με ειδικές εκπαιδευτικές ανάγκες και αναπηρία. Δεδομένης της οργανωσιακής και, συνακόλουθα, παιδαγωγικής σημαντικότητας που έχει η αφοσίωση των εκπαιδευτικών ειδικής αγωγής στο σχολείο στο οποίο υπηρετούν, μελετήθηκαν αντίστοιχοι παράγοντες που συμβάλλουν στην αφοσίωση αυτή. Η μελέτη βασίστηκε σε τυχαίο πανελλαδικό δείγμα 375 εκπαιδευτικών ειδικής αγωγής, που υπηρετούσαν στην Α/θμια Εκπαίδευση. Από τη σχετική στατιστική ανάλυση προέκυψε ότι η επαγγελματική ικανοποίηση αποτελεί τον κύριο προβλεπτικό παράγοντα της αφοσίωσης των εκπαιδευτικών ειδικής αγωγής στο σχολείο που υπηρετούν, ενώ στο μοντέλο πρόβλεψης προσθέτουν σημαντικά τόσο η υποστηρικτική ηγετική συμπεριφορά του διευθυντή του σχολείου όσο και η απουσία αρνητικού συναισθήματος στο χώρο εργασίας.
Μελέτη του επιπέδου της αριθμητικής ικανότητας παιδιού τυπικής ανάπτυξης προσχολικής ηλικίας.
Authors: ΚΥΡΙΑΚΟΥΛΑΚΟΥ ΜΑΡΚΕΛΛΑ ΕΛΕΝΗ
Published: March 2019

Ο σκοπός της παρούσας έρευνας αποτελεί η μελέτη του επιπέδου της αριθμητικής ικανότητας παιδιού τυπικής ανάπτυξης προσχολικής ηλικίας. Για τις ανάγκες διερεύνησης του παραπάνω σκοπού χρησιμοποιήθηκε ποιοτική προσέγγιση. Πιο συγκεκριμένα, πραγματοποιήθηκε μελέτη περίπτωσης σε παιδί προσχολικής ηλικίας τυπικής ανάπτυξης μέσω της χορήγησης μιας σειράς δοκιμασιών από το Κριτήριο Λογικομαθηματικής Σκέψης : LogMath (Δεληκανάκη,2007). Ακόμα, χρησιμοποιήθηκε η μεθοδολογική τεχνική της μη δομημένης παρατήρησης του παιδιού κατά τη διάρκεια χορήγησης του κριτηρίου για την καταγραφή του χρόνου απόκρισης του μαθητή, την εκδήλωση στρατηγικών αποφυγής, καθώς και την αμεσότητα των απαντήσεων. Επιπλέον, χρησιμοποιήθηκε η μεθοδολογική τεχνική της ημι-δομημένης συνέντευξης σε έναν εκ των γονέων του υπό μελέτη παιδιού για την σκιαγράφηση του προφίλ του καθώς και στην νηπιαγωγό του να γίνει διασταύρωση των στοιχείων που συλλέχθηκαν από τη χορήγηση των δοκιμασιών που σχετίζονται με την Αριθμητική Ικανότητα του παιδιού. Ο συνδυασμός των μεθοδολογικών τεχνικών επέτρεψε την υλοποίηση μεθοδολογικής τριγωνοποίησης, έτσι ώστε να ερευνηθεί πολύπλευρα το ζήτημα και να προκύψουν αξιόπιστα και έγκυρα ευρήματα.  Όσον αφορά στα αποτελέσματα που προέκυψαν από την ποιοτική μέθοδο, το παιδί ανταποκρίθηκε σε μεγάλο ποσοστό στο να απαριθμεί αριθμούς από το 1 έως 13. Επίσης, σημειώθηκε δυσκολία στη δραστηριότητα που αφορούσε τη διατήρηση του πλήθους ύστερα από την χωροταξική διάταξη. Ακόμη ήταν σε θέση να αναγνωρίζει όλα τα αριθμητικά σύμβολα από το 1 έως το 10. Τέλος, το επίπεδο της ικανότητας επίλυσης αριθμητικών προφορικών προβλημάτων πρόσθεσης ή αφαίρεσης αξιολογήθηκε ως αρκετά καλό με δυσκολίες να σημειώνονται μόνο στα πιο σύνθετα προβλήματα.
Είναι οι μαθητές μας χαρισματικοί; Απόψεις των εκπαιδευτικών της Πρωτοβάθμιας και Δευτεροβάθμιας εκπαίδευσης για τη χαρισματικότητα
Authors: ΜΕΛΕΤΗ ΕΛΕΝΗ , ΚΥΡΙΑΚΗ ΑΙΚΑΤΕΡΙΝΗ , ΜΠΑΛΑΣΚΑ ΔΗΜΗΤΡΑ , ΧΑΝΤΖΟΥΛΗ ΕΛΕΝΗ
Published: March 2019

Σχετικά με τη χαρισματικότητα έχουν δοθεί ποικίλοι ορισμοί, κάποιοι από τους οποίους εστιάζουν στη δεινότητα και στο ταλέντο, άλλοι στο υψηλό IQ, και άλλοι στις εξαιρετικές επιδόσεις. Σκοπός της μελέτης είναι να διερευνήσει τις απόψεις των εκπαιδευτικών σχετικά με τα χαρακτηριστικά/ανάγκες των χαρισματικών μαθητών, τις στάσεις αναφορικά με τις ενστάσεις ως προς τις παροχές προς τους χαρισματικούς μαθητές και την πιθανή συσχέτιση  προϋπηρεσίας /θέσης με τις απόψεις αυτές. Η έρευνα έγινε σε εκπαιδευτικούς  πρωτοβάθμιας και δευτεροβάθμιας εκπαίδευσης της Γ’ Αθήνας (Ν=278), μέσω δομημένου ηλεκτρονικού ερωτηματολογίου. Τα αποτελέσματα έδειξαν ότι οι εκπαιδευτικοί συνδέουν την έννοια της χαρισματικότητας κυρίως με τα χαρακτηριστικά α) της γρήγορης/ευέλικτης σκέψης, β) του γρήγορου ρυθμού και μεγαλύτερου βάθους μάθησης, γ) την υψηλή απόδοση, δ) την αυξημένη παρατηρητικότητα και ε)  τις εξαιρετικές ικανότητες επίλυσης προβλημάτων. Εκφράζουν την άποψη ότι οι χαρισματικοί μαθητές χρειάζονται ιδιαίτερη προσοχή, και παρόλο που συμφωνούν ότι τα παιδιά με μαθησιακές δυσκολίες έχουν μεγαλύτερη ανάγκη ειδικών εκπαιδευτικών υπηρεσιών, δεν συμφωνούν ιδιαίτερα με τις ενστάσεις ως προς τις παροχές προς τους χαρισματικούς μαθητές. Η θέση εργασίας των συμμετεχόντων δεν μεταβάλλει τις απόψεις τους, ενώ ο χρόνος προϋπηρεσίας σχετίζεται με τις απόψεις για την ανάγκη ειδικής προσοχής και προσαρμοσμένων εκπαιδευτικών υπηρεσιών για τους χαρισματικούς μαθητές.
Assessment of dried blood spots for DNA methylation profiling
Authors: Walker Rosie M. , MacGillivray Louise , McCafferty Sarah , Wrobel Nicola , Murphy Lee , Kerr Shona M. , Morris Stewart W. , Campbell Archie , McIntosh Andrew M. , Porteous David J. , Evans Kathryn L.
Published: March 2019

Background: DNA methylation reflects health-related environmental exposures and genetic risk, providing insights into aetiological mechanisms and potentially predicting disease onset, progression and treatment response. An increasingly recognised need for large-scale, longitudinally-profiled samples collected world-wide has made the development of efficient and straightforward sample collection and storage procedures a pressing issue. An alternative to the low-temperature storage of EDTA tubes of venous blood samples, which are frequently the source of the DNA used in such studies, is to collect and store at room temperature blood samples using purpose built filter paper, such as Whatman FTA® cards. Our goal was to determine whether DNA stored in this manner can be used to generate DNA methylation profiles comparable to those generated using blood samples frozen in EDTA tubes.

Methods: DNA methylation profiles were obtained from matched EDTA tube and Whatman FTA® card whole-blood samples from 62 Generation Scotland: Scottish Family Health Study participants using the Infinium HumanMethylation450 BeadChip. Multiple quality control procedures were implemented, the relationship between the two sample types assessed, and epigenome-wide association studies (EWASs) performed for smoking status, age and the interaction between these variables and sample storage method.

Results: Dried blood spot (DBS) DNA methylation profiles were of good quality and DNA methylation profiles from matched DBS and EDTA tube samples were highly correlated (mean r = 0.991) and could distinguish between participants. EWASs replicated established associations for smoking and age, with no evidence for moderation by storage method.

Conclusions: Our results support the use of Whatman FTA® cards for collecting and storing blood samples for DNA methylation profiling. This approach is likely to be particularly beneficial for large-scale studies and those carried out in areas where freezer access is limited. Furthermore, our results will inform consideration of the use of newborn heel prick DBSs for research use.
Fibring Epistemic and Temporal Logics
Authors: Krawczyk Krzysztof Aleksander
Published: March 2019

Book Reviews: Dariusz Surowik, Logika, wiedza i czas. Problemy i metody temporalno-logicznej reprezentacji wiedzy (Logic, Knowledge and Time. Problems and Methods of Temporal-Logical Representation of Knowledge), Wydawnictwo Uniwersytetu w Białymstoku, Białystok 2013, 357 pages, ISBN 978-83-7431-375-9.
Evaluation of TLC-NOSF dressing with poly-absorbent fibres in exuding leg ulcers: two multicentric, single-arm, prospective, open-label clinical trials
Authors: Sigal Michèle-Léa , Addala Azeddine , Maillard Hervé , Chahim Maxime , Sala Florent , Blaise Sophie , Dalac Sophie , Meaume Sylvie , Bohbot Serge , Tumba Clémence , Tacca Olivier
Published: March 2019

Objective:

To assess the efficacy, safety and acceptability of a new TLC-NOSF dressing with poly-absorbent fibres in the management of exuding leg ulcers, at the different stages of healing.

Method:

This work presents the results of two prospective, multicentric clinical studies: NEREIDES and CASSIOPEE. Patients with a non-infected, moderate-to-strongly exudating leg ulcer of venous or mixed origin, were treated with the dressing and an appropriate compression system for 12 weeks. The wounds included in NEREIDES had to be in debridement stage, and those in CASSIOPEE at granulation stage. In both studies, the primary outcome was the relative wound area reduction (RWAR) at week 12. Main secondary outcomes included healing rate, time-to-reach wound closure, adverse events and acceptability of the dressing by patients and health professionals.

Results:

There were 37 patients included in NEREIDES and 51 in CASSIOPEE. The two cohorts presented similar patient and wound characteristics, except from the percentage of sloughy tissue on wound bed at baseline (median: 75% NEREIDES and 30% CASSIOPEE). At week 12, the RWAR (60% NEREIDES and 81% CASSIOPEE), wound closure rates (18% NEREIDES and 20% CASSIOPEE) and mean times-to-reach wound closure (58±27 days NEREIDES and 55±23 days CASSIOPEE) supported the beneficial outcomes of the treatment in both cohorts. In patients with a wound duration ≤6 months, the wound area reduction reached 85% in NEREIDES and 81% in CASSIOPEE, highlighting the importance to initiate adequate treatment as soon as possible. The nature and frequency of the local adverse events were similar in both studies and consistent with the good safety profiles of the poly-absorbent fibres and of the TLC-NOSF dressings. The acceptability of the dressing (easy to apply, conformable and non-adherent to the wound bed at removal, with no pain or bleeding at removal) has been judged ‘very good’ or ‘good’ at each stage of the healing process, by both nursing staff and patients.

Conclusion:

These clinical results establish the new TLC-NOSF dressing with poly-absorbent fibres (UrgoStart Plus, Laboratoires Urgo) as an effective, safe and simple treatment for the local management of leg ulcers, at the different stages of healing and until wound closure.
Role of sugar-based compounds on cutaneous wound healing: what is the evidence?
Authors: Oryan Ahmad , Alemzadeh Esmat , Moshiri Ali
Published: March 2019

Cutaneous wound healing is a complex orchestrated process influenced by many endogenous and exogenous imbalances. The main goal of tissue regeneration in wound healing is to increase wound contraction and reduce scar formation, effectively to regenerate a new healthy epidermis and prevent scar contracture. Additionally, prevention, control and treatment of wound infections, particularly in burn wounds, is a vital strategy in the healing process. It was previously supposed that local application of sugar-based materials increases the chance of wound infection and delays wound healing. This review shows that topical application of sugar-based compounds has no negative effects on different wound types. Whereas, hyperglycaemia created by diabetes, stress or certain medications can act to impair wound healing. Therefore, this work was designed to review the recent studies that evaluated the role of sugar-based compounds on wound healing and to demonstrate in various cutaneous wound models how these compounds may be involved in healing. It also deals with different physio-pharmacologic conditions resulting in hyperglycaemia in different models of cutaneous wound healing in order to illustrate the role of endogenous glucose in wound healing and remodelling.
Clinical indicators of wound infection and biofilm: reaching international consensus
Authors: Haesler Emily , Swanson Terry , Ousey Karen , Carville Keryln
Published: March 2019

Objective

To achieve international consensus relating to clinical indicators for a chronic wound, wound infection and biofilm presence to inform the development of international clinical guidance for assessing and managing wound infection.

Method

An online Delphi consensus process of international key opinion leaders in infection was undertaken. A literature search underpinned the development of issue statements related to terminology, emerging topics and debate in the field of wound infection. Experts participated in three rounds of consensus voting, sharing their opinions and indicating their level of agreement with the issue statements. Votes were calculated using web-based software that implements a nominal group voting methodology previously published by Research and Development/University of California at Los Angeles.

Results

A total of 14 experts took part in the development process. Consensus was reached on clinical indicators of wound chronicity, wound infection and biofilm presence. Agreement was also reached that the term ‘critical colonisation’ should no longer be used to refer to a stage in the wound infection continuum.

Conclusion

Outcomes from the consensus process were used to inform the development of international, evidence-informed guidance on the assessment and treatment of wound infection to promote improved outcomes for people with wounds.
Lectio Divina and meditation: Exploring identity through contemplative practices
Authors: Dalton Jane E.
Published: March 2019

Engaging in contemplative practices, such as breath and body awareness, meditation, silence and the arts, allows for engagement in the deep work of identity construction to uncover ‘the self who teaches’ (Palmer 1998: 7). Through Lectio Divina, an ancient Benedictine practice, the work of identity construction is deepened through examination of the way in which words and imagery strengthen and support the inner life of the teacher. Researching and engaging in contemplative inquiry and practices, as well as teaching these practices to pre-service teachers, weaves together a tapestry of my identities as an artist–teacher–researcher. These practices support embodied experiences of deep-thought and reflection that includes the cognitive, the affective and the spiritual.
An Empirical Exploration of the Perceived Effectiveness of a ‘Flipped Classroom’ in a Business Communication Course
Authors: Pérez Andrea , Collado Jesús , Del Mar García de los Salmones María , Herrero Ángel , San Martín Héctor
Published: March 2019

This paper explores a causal model, using Structural Equation Modelling (SEM), in order to understand how the perceived effectiveness of ‘flipped classroom’ and students’ satisfaction with this technique can be affected by students’ engagement in ‘flipped classroom’ activities as well as the complexity and task orientation of such activities. The findings of the study confirm that the perceived effectiveness of the ‘flipped classroom’ can be calculated by its contribution to the improvement of students’ general skills, knowledge and learning motivation. Students’ engagement in the ‘flipped classroom’ activities is the key factor influencing perceived effectiveness and students’ satisfaction, while the complexity and task orientation of the ‘flipped classroom’ also play a role in determining perceived effectiveness and satisfaction, although indirect and always mediated by engagement.
Global Commodity Chains and the New Imperialism
Authors: Suwandi Intan , Jonna R Jamil , Foster John Bellamy
Published: March 2019

To comprehend twenty-first-century imperialism we must go beyond analysis of the nation-state to a systematic investigation of the increasing global reach of multinational corporations or the role of the global labor arbitrage. At issue is the way in which today's global monopolies in the center of the world economy have captured value generated by labor in the periphery within a process of unequal exchange, thus getting "more labour in exchange for less. The result has been to change the global structure of industrial production while maintaining and often intensifying the global structure of exploitation and value transfer.
Self-Knowledge, Estrangement, and Social Metabolism
Authors: Hennig Boris
Published: March 2019

Following two key themes in Karl Marx's thought—estrangement and political economy, in their relation to human self-knowledge—labor mediates the social metabolism. In this schema, organic (or functional) metabolism is distinguished from extended metabolism (or social organization). Socially extended metabolism gives rise to shared values and concepts in the same way that organic metabolism gives rise to life. On this basis, I suggest that both the subject and object of human self-knowledge is a socially extended self, which can connect to itself only when humans freely participate in socially extended metabolism—that is, economy, science, and industry. Estrangement, in contrast, is seen to result from a disruption within socially extended metabolism.
Eco-Economic Incentives of Rational Land Use and Protection in Ukraine
Authors: SANNIKOV Dmytro V.
Published: March 2019

The work represents a problem, which is defined by complex decision. The work shows that land recultivation and protection are usually offered as accompanying expenses for land exploitation. The authors demonstrate that the solution to the problem should be of eco-economic character. It is suggested to use not only legislative measures to enforce land users to restore land fund, but also to stimulate it. The work determines economic, legal and administrative solutions, which are aimed to enable the state to stimulate the principles or rational use of Ukrainian land resources. The work states that necessary measures have already been represented in Ukraine on the legislative level. It is suggested to be more oriented towards environmental constituent and to determine the direction of the formation of integrated perception of the state incentives mechanism. The novelty of study lies in the statement that incentives bring about not only a direct economic effect, but also ecological understanding of the improvement of human environment. The work represents aspects of the formation of economic tools of eco-economic measures, and there is calculated the economic effect. The authors of work concluded that the prospective direction is an economic approach as the basis of synergetic approach in conditions of the integration of Ukraine in the world space.
Legal Fundamentals of the Kazakhstan’s Environmental International Cooperation: New Vectors of Legislative Reforms
Authors: KALAGANOV Bakhytbek , MADIYAROVA Ainur S. , SARTAYEVA Kaliya R. , KIM Elina P. , APAKHAYEV Nurlan , BURIBAYEV Yermek A.
Published: March 2019

For the last decades the international community has strengthened response to environmental challenges and signing of multilateral documents, the intensification of partnership in the environmental sphere remains one of the most effective solutions of such problems. Today we can speak about ecologization of the international cooperation and state policies which has affected the CIS countries including the Republic of Kazakhstan. At this stage of the state’s development environmental legislation of the republic can be characterized as the demonstration of immense complexity and contradictory processes, being deficient, developing quite chaotically and depending on a political climate. However, the environmental international cooperation, expansion of contractual framework and approbation of the best foreign practices are capable to transform qualitatively the Kazakhstan’s environmental legislation system and to outline new legal reformation vectors. Within the research environmental policy formation’s features of the Kazakhstan Republic in the conditions of globalization and world environmental degradation were defined; legal fundamentals of the republic’s environmental international cooperation were analyzed; influential role of Kazakhstan’s international treaties on the national environmental legislation system was characterized; legal perspectives of the Kazakhstan’s environmental legislation reformation in the context of further interstate environmental cooperation development were outlined. “The environmental international cooperation strategy of the Kazakhstan’s Republic” was recommended for the appropriate formation of the reforms’ concept development and acceptance.
Environmental Management Systems and Environmental Performance: The Case of Russian Energy Sector
Authors: IOSIFOV Valery V. , RATNER Svetlana V.
Published: March 2019

Nowadays one of the most common organizational eco-innovations in energy companies is introducing environmental management systems (EMS). Nevertheless, the issues of environmental and economic efficiency of EMS remain controversial. The purpose of this work is to develop a methodology for assessing the effectiveness of environmental management systems of Russian energy companies certified in accordance with ISO 14001. Since Russian companies do not have EMAS conformance certificates, the issues of the effectiveness of environmental management systems under the European Environmental Management Scheme and eco-audit were not considered in this study. The study is based on the data from annual corporate reports of the largest energy companies of the Russian Federation, which have the organizational and legal form of public joint-stock companies. The selection criteria were: i) the existence of an integrated management system, which is based on a certified environmental management system; ii) the presence in the corporate reports of data on the environmental performance of the company, at least a few years before and after the introduction of EMS, sufficient for statistical analysis using a two depended samples T-test. The study has shown that the application of ISO 14001 can be considered as a condition for the development of eco-innovation, as a well-designed environmental management strategy covers the whole range of issues related to innovative development, modernization and competitiveness. The introduction of EMS is also associated with an increase in the information transparency of the entire production system of the company, which is also a positive point in terms of the development of innovative processes.
Methodological Aspects of Formation and Development of National Innovation Systems
Authors: TUREKULOVA Dametken , MUKHAMBETOVA Lyazzat , KURMANKULOVA Nurzhamal , KEMALOVA Ainur , SATKANOVA Rimma , BERMUKHAMEDOVA Galiya
Published: March 2019

The article considers various approaches to the understanding of the term "national innovation system", presents the author's vision of this category. The history of the emergence and evolution of the development of the concept of a national innovation system has been studied, the main directions for the development of national innovation systems in foreign countries, and tools to support the national innovation system are presented. The characteristic of models of national innovation systems is given.
Green Bonds like the Incentive Instrument for Cleaner Production at the Government and Corporate Levels: Experience from EU to Ukraine
Authors: CHYGRYN Olena , PIMONENKO Tetyana , LUYLYOV Oleksii , GONCHAROVA Alina
Published: March 2019

The paper deals with analysis of the main features and perspectives of green bonds development. Under the investigation the European Union experience of developing and functioning the green bonds market were analysed by the authors. The authors systematised the main approaches to define green bonds. Thus, the green bonds were defined as the debt investment in which an investor loans money which borrows the funds for a defined period at a variable or fixed interest rate with purpose to raise money and finance the variety of green projects and activities. In this direction, green projects mean the all activities which connected with resources saving and environmental protection activities. According to this result, the main features, parameters and principles of green bonds were indicated by the authors. Besides, based on the European Union experience the authors allocated the main pre-requisites of developing the green bonds market in Ukraine. Moreover, the authors allocated the main players at the green bonds market. According to the European Union experience and Ukraine conditions, the attractive directions of green bonds market for investors were identified by the authors. With this purpose the authors tried to consolidate the main advantages and disadvantages of green bonds for investors. According to the results, in conclusion, the authors allocated the possible economic, social, political and environmental benefits of green bonds market for issuers with purpose to attract their attention and to develop the green bonds market in Ukraine.
Evaluation of the Influence of External Environmental Factors on Logistics Activities: Case Study of Ukrainian Retail Trade Enterprises
Authors: SHTAL Tatyana V. , UVAROVA Anastasiya , OSTAPENKO Iuliia I.
Published: March 2019

The article examines the influence of the external environment on the logistics activities of retail trade enterprises of Ukraine. External factors of logistics activities of retail trade enterprises, substantiated indexes of their evaluation were determined. The volume and composition of consumer demand, the development of the market of logistics services, efficiency of logistics activities and the state of competition in the retail market were analysed. Diagnosed the decrease in the efficiency of logistics activities of retail trade enterprises and the high level of its dependence on the factors of environment. The prospect of future research in this direction was formulated.
PENCEGAHAN PERUSAKAN HUTAN BERBASIS MASYARAKAT ADAT DALIHAN NA TOLU DI TAPANULI SELATAN
Authors: Harahap Anwar Sadat , Hasibuan Ahmad Laut
Published: March 2019

There are indigenous peoples who have their own traditional value in passing the prevention of forest destruction. Before the establishment of legislation on Preventing Forest Destruction in Indonesia, the indigenous people of Dalihan na Tolu have their own rules in preventing forest destruction. The customary law of Dalihan na Tolu has governed: the model of settlement of forest degradation disputes, the universal rules of indigenous peoples of Dalihan na Tolu on the prevention of forest destruction, the form of sanctions imposed on forest destruction parties, and the form of oversight in the implementation of the prevention of forest destruction.
PROSES LITERASI HUKUM ADAT KAMPUNG TARUNG NUSA TENGGARA TIMUR : UPAYA PENGAKUAN EKSISTENSI
Authors: Palar Miranda Risang Ayu , Sungkar Lailani
Published: March 2019

Legal means to obtain the recognition of indigenous communities in Indonesia are still scattered in a number of different regulations. Law on Village 2014 also obligates the government to arrange the system to conduct legal acknowledgements for Adat Villages. Tarung Village is a traditional village which situated in West Sumba Regency. The Members are still living in their own customary laws and embracing their local spiritual belief system as a living culture. Until recently, their village haven’t yet enjoyed the formal ackonwledgement they deserve as a united indigenous community nor as Adat Village. A number of mechanisms to obtain the acknowledgment require particular processes of identification and validation. This research is an initial effort to undertake the processes. In addition, it also aims to conduct a defensive legal protection by documenting the customary laws with interview method. The result displays the legal means to gain the existential acknowledgement which had been undertaken by the custodians of The Village and the Local Government.
PLURALISME HUKUM PROGRESIF: MEMBERI RUANG KEADILAN BAGI YANG LIYAN
Authors: Mukminto Eko , Marwan Awaludin
Published: March 2019

When ideological contestation in law is controlled by the logic of the majority. Then the consequences of the legal logic will be controlled by the logic of oppression. In this context, minorities whether based on religion, ethnicity, gender or sexuality are difficult to pursuit justice. Access to justice is possible as long as minority representation is also present in state law. This paper aims to examine the concept of legal pluralism in Progressive law. Thus, it will also provide alternative ideas for resolving the problem of discrimination of minority groups. Satjipto Rahardjo’s Progressive law has a philosophical basis that sees that the discourse of law is never be final and legal pluralism will provide justice. In the progressive law reasoning, legal pluralism will be discussed with recognition and redistribution political theory, so that it will tear down constellation of hierarchical structures and provides justice for minorities or “the others”. Therefore, state law is no longer the rule of majority.
RESTATEMENT TENTANG YURIDIKSI PERADILAN MENGADILI PERBUATAN MELAWAN HUKUM PEMERINTAH (RESTATEMENT ON JUDICIAL JURISDICTION IN ADMINISTRATIVE TORT)
Authors: Simanjuntak Enrico Parulian
Published: March 2019

One of the crucial problems after enactment of Government Administration Act (UUAP) concerns the extent to which the scope of court jurisdiction relating administrative torts (onrechtmatige overheidsdaad) or OOD, as intended in Article 1365 of the Civil Code. There are at least two different views on the issue. First, administrative court mutatis mutandis has power to resolve the case relating onrechtmatige overheidsdaad, this view is represented by Supreme Court Circular or Surat Edaran Mahkamah Agung (SEMA) No. 4/2016. A different view holds that the OOD act is a genus whereas the factual act as referred to UUAP is a species. This second view is not mutatis mutandis totally transferring the authority of civil judges to administrative court try the OOD case. This difference of opinion is important to be studied more thoroughly in order to know the real issue of the different views.
Perancangan dan Pembuatan Data Logger Sederhana untuk Dinamometer Sasis Sepeda Motor
Authors: Sinaga Nazaruddin
Published: March 2019

Sepeda motor merupakan salah satu alat transportasi utama yang jumlahnya sangat banyak di Indonesia, sehingga memicu munculnya banyak bengkel. Untuk melakukan pengukuran kinerja sepeda motor dengan tepat dibutuhkan dinamometer. Tujuan penelitian ini adalah membuat sebuah data logger sederhana yang dapat digunakan pada dinamometer sasis sepeda motor jenis inersia dan absorbsi. Data logger yang dibuat menggunakan modul data akuisisi NI-DAC USB 6212, dan pemrograman sistem pengukuran menggunakan perangkat lunak LabVIEW. Dari penelitian ini telah berhasil dibuat sebuah data logger untuk pengujian kinerja sepeda motor yang dapat mengukur kecepatan putar mesin dan roda sepeda motor, torsi, daya, dan temperatur, dengan menggunakan sensor induktive pickup, proximity sensor, load cell, dan termometer. Perbandingan hasil uji torsi dan daya, antara data logger yang dibuat dengan nilai spesifikasi yang dikeluarkan oleh pabrik pembuat sepeda motor, menunjukkan perbedaan yang kecil. Dari hasil uji didapatkan bahwa ketidakpastian alat ukur yang dibuat ini memiliki ketidakpastian pengukuran torsi sebesar UTe =  ± 2,15% dan ketidakpastian pengukuran daya UPe =  ± 2,05%, jika digunakan pada dinamometer absorbsi. Pada dinamometer inersia, ketidakpastian pengukuran torsi adalah sebesar UTe =  ± 1,61%, dan ketidakpastian pengukuran daya UPe =  ± 1,76%. Hasil penelitian ini jika dikembangkan dengan memanfaatkan DAQ yang lebih murah tentu dapat berkontribusi untuk menurunkan harga dinamometer secara keseluruhan.
Pengaruh Jarak Penembakan pada Pelapisan 95MXC Terhadap Sifat Kekerasan dan Keausan Material SS 304 dengan metode Twin Wire Arc Spray (TWAS)
Authors: Fitriyana Deni Fajar , Haryadi Gunawan Dwi , Sulardjaka Sulardjaka , Iskandar Norman , Amrizal Abdi Gilang
Published: March 2019

Proses pelapisan pada SS 304 dengan metode thermal spray dapat di pertimbangkan sebagai metode untuk peningkatan ketahan aus. Dalam penelitian ini bertujuan untuk mengetahui pengaruh jarak penembakan pada proses pelapisan SS 304 dengan metode twin wire arc spray coating terhadap peningkatan ketahanan aus dengan material coating 95MXC. Variasi jarak penembakan yang digunakan adalah 100 mm, 200 mm, 300 mm dan 400 mm dengan air pressure 4 bar. Dari hasil penelitian, pada jarak penembakan 100 mm menghasilkan nilai kekerasan 1227 HV, nilai laju keuasan 4,0x10-4 mm3/s, nilai presentase porositas dan unmelt 9,278% dan kekuatan lekat coating sebesar 22,62 MPa. Semakin dekat jarak penembakan, nilai kekerasan yang dihasilkan akan semakin tinggi sehingga nilai laju keausan yang didapatkan menurun. Hal tersebut dikarenakan rendahnya nilai presentase porositas dan unmelt.