bluuebunny/crossref_metadata_2025 huggingface dataset:
ChemInform Abstract: A Broensted Acid‐Amino Acid as a Synergistic Catalyst for Asymmetric List—Lerner—Barbas Aldol Reactions.
Authors: Ramachary Dhevalapally B. , Shruthi Kodambahalli S.
Published: July 2016

The combination of a thiazole‐based amino acid with TFA provides a synergistic catalyst for the asymmetric LLB aldol reaction of less reactive o‐azidobenzaldehydes with simple ketones.
ChemInform Abstract: Switching the Cleavage Sites in Palladium on Carbon‐Catalyzed Carbon—Carbon Bond Disconnection.
Authors: Hattori Tomohiro , Takakura Ryoya , Ichikawa Tomohiro , Sawama Yoshinari , Monguchi Yasunari , Sajiki Hironao
Published: July 2016

The regioselectivity of C—C bond cleavage in cinnamaldehyde derivatives can be altered by slight change of the reaction conditions.
ChemInform Abstract: N‐Rich Fused Heterocyclic Systems: Synthesis, Structure, Optical and Electrochemical Characterization.
Authors: Fusco Sandra , Maglione Cira , Velardo Amalia , Piccialli Vincenzo , Liguori Rosalba , Peluso Andrea , Rubino Alfredo , Centore Roberto
Published: July 2016

Acid‐mediated condensation of diones (I) with diamino triazole (II) produces nitrogen‐rich fused heterocycles.
ChemInform Abstract: A New Approach for the Synthesis of Highly Substituted Aromatic Rings: The Alkyne‐Mediated Approach.
Authors: Parsons Philip J. , Jones Daniel R. , Padgham Alex C. , Allen Lewis A. T. , Penkett Clive S. , Green Robert A. , White Andrew J. P.
Published: July 2016

Pentasubstituted aromatic rings, useful templates for drug design, are prepared by thermolysis of suitably substituted alkynes under microwave conditions.
ChemInform Abstract: Synthesis of Nitriles from Amines Using Nanoscale Co3O4‐Based Catalysts via Sustainable Aerobic Oxidation.
Authors: Natte Kishore , Jagadeesh Rajenahally V. , Sharif Muhammad , Neumann Helfried , Beller Matthias
Published: July 2016

This green and selective oxidation process for the synthesis of nitriles from amines using molecular oxygen and aqueous ammonia is catalyzed by a nanostructured cobalt oxide‐based material, which is activated by nitrogen‐doped graphene layers.
ChemInform Abstract: Chemoselective Reduction of Tertiary Amides under Thermal Control: Formation of Either Aldehydes or Amines.
Authors: Tinnis Fredrik , Volkov Alexey , Slagbrand Tove , Adolfsson Hans
Published: July 2016

A new catalytic hydrosilylation protocol for the reduction of tertiary amides is reported.
ChemInform Abstract: CuSO4‐Mediated Decarboxylative Difluoroacetamidation of α,β‐Unsaturated Carboxylic Acids.
Authors: Chen Qiao , Wang Chao , Zhou Jiawei , Wang Yanan , Xu Zhaoqing , Wang Rui
Published: July 2016

An efficient protocol for preparation of difluorinated alkenes is presented.
ChemInform Abstract: Iron‐Catalyzed Allylic Amination Directly from Allylic Alcohols.
Authors: Emayavaramban Balakumar , Roy Moumita , Sundararaju Basker
Published: July 2016

The title reaction is performed directly from alcohols without any activator.
ChemInform Abstract: Metal‐Free Allylation of Electron‐Rich Heteroaryl Boronic Acids with Allylic Alcohols.
Authors: Li Xue‐Dong , Xie Li‐Jun , Kong De‐Long , Liu Li , Cheng Liang
Published: July 2016

The regioselective cross‐coupling of heteroaryl boronic acids with allylic alcohols works under external oxidant‐ and metal‐free conditions, and proves to be very general with an unprecedented selectivity for ortho‐functionalization of the boronic acids.
ChemInform Abstract: General Method for Nucleophilic Aromatic Substitution of Aryl Fluorides and Chlorides with Dimethylamine Using Hydroxide‐Assisted Decomposition of N,N‐Dimethylforamide.
Authors: Garcia Juana , Sorrentino Jacob , Diller Emily J. , Chapman Daniel , Woydziak Zachary R.
Published: July 2016

The synthesis can be scaled up to gram quantities without significant change in yield.
ChemInform Abstract: Synthesis of Aryldifluoroamides by Copper‐Catalyzed Cross‐Coupling.
Authors: Arlow Sophie I. , Hartwig John F.
Published: July 2016

Various aryl, heteroaryl, and vinyl iodides are coupled with α‐silyldifluoroamides with good functional group tolerance.
ChemInform Abstract: Palladium‐Catalyzed N‐Arylation of Cyclopropylamines.
Authors: Gildner Peter G. , DeAngelis Andrew , Colacot Thomas J.
Published: July 2016

Highly active, air‐stable allyl/crotyl‐palladium precatalysts promote the title reactions under somewhat different conditions.
ChemInform Abstract: Expanding the Scope of Primary Amine Catalysis: Stereoselective Synthesis of Indanedione‐Fused 2,6‐Disubstituted trans‐Spirocyclohexanones.
Authors: Madhusudhan Reddy G. , Ko Chi‐Ting , Hsieh Kai‐Hong , Lee Chia‐Jui , Das Utpal , Lin Wenwei
Published: July 2016

Mechanistic investigation of these organo‐catalytic spirocyclizations reveals two competing pathways: a concerted Diels—Alder reaction and a stepwise Michael addition.
ChemInform Abstract: Spirocyclopropanation Reaction of para‐Quinone Methides with Sulfonium Salts: The Synthesis of Spirocyclopropanyl para‐Dienones.
Authors: Zhang Xiang‐Zhi , Du Ji‐Yuan , Deng Yu‐Hua , Chu Wen‐Dao , Yan Xu , Yu Ke‐Yin , Fan Chun‐An
Published: July 2016

A diastereoselective spirocyclopropanation is achieved using a chiral binaphthyl‐based sulfonium salt.
ChemInform Abstract: Substrate‐Dependent Mechanistic Divergence in Decarboxylative Heck Reaction at Room Temperature.
Authors: Hossian Asik , Bhunia Samir Kumar , Jana Ranjan
Published: July 2016

Heck‐type reactions between arene carboxylic acids and alkenes proceed by two distinct pathways: electron‐rich compounds undergo Pd(II)‐catalyzed decarboxylation while silver(I)‐assisted decarboxylation works for electron‐deficient substrates.
ChemInform Abstract: Transition Metal‐Free Dimerization of Alkynes Using Hypervalent Iodine Reagents.
Authors: Schoergenhumer Johannes , Waser Mario
Published: July 2016

The use of acetoxybenziodoxole as activating agent facilitates the homo‐coupling of terminal alkynes under operationally simple conditions to give aryl‐ and alkyl‐substituted 1,3‐diynes.
ChemInform Abstract: Enantioselective Benzoin Condensation Catalyzed by Spirocyclic Terpene‐Based N‐Heterocyclic Carbenes.
Authors: Rafinski Zbigniew
Published: July 2016

A series of new chiral spirocyclic triazolium salts, derived from (1S)‐fenchone and (IR)‐camphorquinone, act as N‐heterocyclic carbene precatalysts and are employed in the catalytic asymmetric benzoin condensation to afford acyloins.
ChemInform Abstract: Cobalt(II)‐Catalyzed C—H Amination of Arenes with Simple Alkylamines.
Authors: Zhang Lin‐Bao , Zhang Shou‐Kun , Wei Donghui , Zhu Xinju , Hao Xin‐Qi , Su Jian‐Hang , Niu Jun‐Long , Song Mao‐Ping
Published: July 2016

A broad spectrum of arylamides can be readily ortho‐aminated with simple six‐membered secondary amines.
ChemInform Abstract: Catalytic Asymmetric Synthesis of Enantioenriched β‐Nitronitrile Bearing a C‐CF3 Stereogenic Center
Authors: Jakhar Ajay , Kumari Prathibha , Nazish Mohd , Khan Noor‐ul H. , Kureshy Rukhsana I. , Abdi Sayed H. R. , Suresh E.
Published: July 2016

by hydrocyanation reaction using an in situ generated chiral Ti(IV) salen complex as catalyst
ChemInform Abstract: Synthesis of Vinyl Isocyanides and Development of a Convertible Isonitrile.
Authors: Spallarossa Martina , Wang Qian , Riva Renata , Zhu Jieping
Published: July 2016

The Wittig reaction of isocyanomethylenetriphenylphosphorane, in situ generated from the corresponding phosphonium salts, with various aldehydes affords vinyl isocyanides with good to high yields.
ChemInform Abstract: Aryl and Heteroaryl Nosylates as Stable and Cheap Partners for Suzuki—Miyaura Cross‐Coupling Reactions.
Authors: Dikova Anna , Cheval Nicolas P. , Blanc Aurelien , Weibel Jean‐Marc , Pale Patrick
Published: July 2016

First time, (het)aryl para‐nitrophenylsulfonates (nosylates) are successfully used in Suzuki—Miyaura cross‐coupling reactions with various aryl or vinylboronic acids.
ChemInform Abstract: Design, Synthesis, and Validation of an Effective, Reusable Silicon‐Based Transfer Agent for Room‐Temperature Pd‐Catalyzed Cross‐Coupling Reactions of Aryl and Heteroaryl Chlorides with Readily Available Aryl Lithium Reagents.
Authors: Martinez‐Solorio Dionicio , Melillo Bruno , Sanchez Luis , Liang Yong , Lam Erwin , Houk K. N. , Smith Amos B. III
Published: July 2016

In continuation of previously published studies, an improved silicon‐based transfer agent allowing for cross‐coupling reactions using (hetero)aryl chlorides is designed.
ChemInform Abstract: Open‐Shell Phenalenyl in Transition Metal‐Free Catalytic C—H Functionalization.
Authors: Paira Rupankar , Singh Bhagat , Hota Pradip Kumar , Ahmed Jasimuddin , Sau Samaresh Chandra , Johnpeter Justin P. , Mandal Swadhin K.
Published: July 2016

A phenalenyl ligand (MAP) promotes a chelation‐assisted single electron transfer process, facilitating the C—H functionalization of unactivated arenes to form the biaryl products.
ChemInform Abstract: On‐Water Synthesis of Biaryl Sulfonyl Fluorides.
Authors: Chinthakindi Praveen K. , Kruger Hendrik G. , Govender Thavendran , Naicker Tricia , Arvidsson Per I.
Published: July 2016

This ligand‐ and additive‐free Suzuki—Miyaura‐coupling protocol is compatible with the —SO2—F group, giving access to a wide range of bioorthogonal click reagents.
ChemInform Abstract: Highly Enantioselective Rhodium‐Catalyzed Addition of Arylboroxines to Simple Aryl Ketones: Efficient Synthesis of Escitalopram.
Authors: Huang Linwei , Zhu Jinbin , Jiao Guangjun , Wang Zheng , Yu Xingxin , Deng Wei‐Ping , Tang Wenjun
Published: July 2016

A range of chiral diaryl alkyl carbinols is prepared with excellent yields and enantioselectivities as well as broad functional group tolerance utilizing a Rh/(R,R,R,R)‐WingPhos catalyst.
ChemInform Abstract: Copper‐ versus Palladium‐Catalyzed Aromatization of 2‐(Methoxycarbonyl) Tetralones: Synthesis of Methyl 1‐Hydroxy‐2‐naphthoates.
Authors: Civicos Jose F. , Ribeiro Carlos M. R. , Costa Paulo R. R. , Najera Carmen
Published: July 2016

The aromatization of α‐tetralones substituted at the β‐position by an ester group is reported catalyzed either by CuI or Pd2(dba)3.
ChemInform Abstract: Insertion of N‐Tosylacetimidates/Acetimidamides onto Arynes via [2 + 2] Cycloaddition.
Authors: Kranthikumar Ramagonolla , Chegondi Rambabu , Chandrasekhar Srivari
Published: July 2016

This novel insertion reaction proceeds via formation of a benzocyclobutene intermediate followed by ring cleavage.
ChemInform Abstract: Synthesis of Oxygenated 1‐Arylnaphthalenes.
Authors: Chang Meng‐Yang , Huang Yi‐Hsuan , Wang Heui‐Sin
Published: July 2016

The Lewis acid‐mediated one‐pot tandem benzannulation of alkynols with oxygenated benzenes provides arylnapthalenes in moderate to good yields.
ChemInform Abstract: Hydrogen‐Bonding Network Promoted [3 + 2] Cycloaddition: Asymmetric Catalytic Construction of Spiro‐Pseudoindoxyl Derivatives.
Authors: Zhang Liang‐Jie , Wang Yao , Hu Xiu‐Qin , Xu Peng‐Fei
Published: July 2016

Spiro‐pseudoindoxyl derivatives with three stereocenters including one quaternary one are formed in high yields, with excellent diastereoselectivities and high enantioselectivities.
ChemInform Abstract: The First Enantioselective Organocatalytic Synthesis of 3‐Spiro‐α‐alkylidene‐γ‐butyrolactone Oxindoles.
Authors: Cerisoli Lucia , Lombardo Marco , Trombini Claudio , Quintavalla Arianna
Published: July 2016

β‐Nitro oxindoles react with a broad range of alkyl as well as alkenyl and aryl aldehydes to form the title products which are isolated with moderate to high diastereoselectivity and high enantioselectivity in favor of the (Z)‐isomer.
ChemInform Abstract: La(OTf)3‐Catalyzed, Three‐Component Synthesis of Spiro[Indolo‐3,10′‐indeno[1,2‐b]quinolin]‐2,4,11′‐triones in PEG‐400 under Conventional Heating and Ultrasonic Irradiation.
Authors: Kumari Sudesh , Rajeswari M. , Khurana J. M.
Published: July 2016

An efficient and environmentally benign approach for the synthesis of the title triones by one‐pot, three‐component condensation of indandione, isatins, and enaminones is developed.
ChemInform Abstract: Biomimetic Epoxidation in Aqueous Media Catalyzed by Cyclic Dipeptides.
Authors: Berube Christopher , Voyer Normand
Published: July 2016

The enantioselective organocatalyzed epoxidation of α,β‐unsaturated ketones by 2,5‐diketopiperazines in aqueous media is reported.
ChemInform Abstract: Synthesis of Furans and Pyrroles from 2‐Alkoxy‐2,3‐dihydrofurans Through a Nucleophilic Substitution‐Triggered Heteroaromatization.
Authors: Liu Changhui , Zhou Li , Huang Wenbo , Wang Man , Gu Yanlong
Published: July 2016

2‐Butoxy‐substituted‐2,3‐dihydrofurans and a variety of carbon nucleophiles offer a diverse synthesis of furans, pyrroles, and dihydrothiophenes in the presence of a Cu‐ or Fe‐catalyst.
ChemInform Abstract: Oxidative Cyclization of 1,5‐Dienes with Hydrogen Peroxide Catalyzed by an Osmium(III) Complex: Synthesis of cis‐Tetrahydrofurans.
Authors: Sugimoto Hideki , Kanetake Takayuki , Maeda Kazuki , Itoh Shinobu
Published: July 2016

The cyclization proceeds with high stereoselectivity to afford cis‐tetrahydrofurans in low yields.
ChemInform Abstract: Dual Catalysis: Proton/Metal‐Catalyzed Tandem Benzofuran Annulation/Carbene Transfer Reaction.
Authors: Ma Jun , Chen Kai , Fu Hongguang , Zhang Li , Wu Wanqing , Jiang Huanfeng , Zhu Shifa
Published: July 2016

o‐Hydroxyl‐benzylalcohols bearing an acetylenic amine side chain are subjected to conditions A).
ChemInform Abstract: A Calcium Catalyzed Regioselective (5‐exo Dig) Tandem Process for the Synthesis of Fully Substituted Furans.
Authors: Yaragorla Srinivasarao , Dada Ravikrishna , Pareek Abhishek , Singh Garima
Published: July 2016

Fused furans are prepared from alkynols and coumarins or cyclohexanediones via cascade reaction involving alkylation, 5‐exo dig cyclization, and isomerization.
ChemInform Abstract: Palladium(II)‐Catalyzed Synthesis of Dibenzothiophene Derivatives via the Cleavage of Carbon—Sulfur and Carbon—Hydrogen Bonds.
Authors: Tobisu Mamoru , Masuya Yoshihiro , Baba Katsuaki , Chatani Naoto
Published: July 2016

The title reaction is mechanistically uncommon because the product forming step is the oxidative addition instead of reductive elimination.
ChemInform Abstract: Synthesis of Benzo[c]thiophenes by Rhodium(III)‐Catalyzed Dehydrogenative Annulation.
Authors: Fukuzumi Keita , Unoh Yuto , Nishii Yuji , Satoh Tetsuya , Hirano Koji , Miura Masahiro
Published: July 2016

Some of the annulated thiophene derivatives show strong solid‐state fluorescence.
ChemInform Abstract: Ligand‐Enabled γ‐C(sp3)—H Olefination of Amines: En route to Pyrrolidines.
Authors: Jiang Heng , He Jian , Liu Tao , Yu Jin‐Quan
Published: July 2016

These reactions proceed by Pd‐catalyzed amine olefinations followed by aza‐Wacker oxidative cyclization or conjugate addition.
ChemInform Abstract: Ligand‐Free Pd‐Catalyzed Domino Synthesis of Carbazoles via Dehydrogenative Aromatization/C(sp2)—C(sp2) Coupling Sequence.
Authors: Wen Lixian , Tang Lin , Yang Yu , Zha Zhenggen , Wang Zhiyong
Published: July 2016

The protocol works in the absence of a ligand and can be applied to a series of anilines and cyclohexanones.
ChemInform Abstract: Ruthenium(II)‐Catalyzed Synthesis of Pyrrole‐ and Indole‐Fused Isocoumarins by C—H Bond Activation in DMF and Water.
Authors: Singh Keisham S. , Sawant Sneha G. , Dixneuf Pierre H.
Published: July 2016

The title reaction uses pyrrole‐2‐carboxylic acids and indole‐3‐carboxylic acids as starting material and copper acetate as oxidant.
ChemInform Abstract: Bi‐ and Trinuclear Copper(I) Complexes of 1,2,3‐Triazole‐tethered NHC Ligands: Synthesis, Structure, and Catalytic Properties.
Authors: Gu Shaojin , Du Jiehao , Huang Jingjing , Xia Huan , Yang Ling , Xu Weilin , Lu Chunxin
Published: July 2016

The title complexes are prepared via reaction of imidazolium salt ligands with copper powder.
ChemInform Abstract: I2‐Catalyzed Oxidative Coupling Reactions of Hydrazones and Amines and the Application in the Synthesis of 1,3,5‐Trisubstituted 1,2,4‐Triazoles.
Authors: Chen Zhengkai , Li Hongli , Dong Weipeng , Miao Maozhong , Ren Hongjun
Published: July 2016

The metal‐free rapid procedure renders possible the synthesis of a broad spectrum of structurally diverse title compounds (mechanism).
ChemInform Abstract: Urea Assisted Copper(I)‐Catalyzed Azide—Alkyne Cycloaddition Reactions in Water.
Authors: Ali Abdul Aziz , Chetia Mitali , Sarma Diganta
Published: July 2016

The novel three‐component catalyst system allows the highly efficient and regioselective synthesis of 1,4‐disubstituted triazoles.
ChemInform Abstract: Synthesis of N1 and N2 Coumarin Substituted 1,2,3‐Triazole Isomers via Click Chemistry Approach
Authors: Shamala Devadas , Shivashankar Kalegowda , Chandra Kalegowda , Mahendra Madegowda
Published: July 2016

from terminal alkynes, sodium azide, and bromomethylcoumarins
ChemInform Abstract: Benzyltrimethylammoniumfluoride Hydrate: An Efficient Catalyst for One‐Pot Synthesis of Hantzsch 1,4‐Dihydropyridines and Their Aromatization.
Authors: Khaskel Anamika , Barman Pranjit
Published: July 2016

A simple and cost‐effective approach for the synthesis of Hantzsch 1,4‐dihydropyridines under solvent‐free reaction conditions and a new method for their efficient oxidation are developed.
ChemInform Abstract: Graphene Oxide: A Reusable and Metal‐Free Carbocatalyst for the One‐Pot Synthesis of 2‐Amino‐3‐cyanopyridines in Water.
Authors: Khalili Dariush
Published: July 2016

The facile one‐pot protocol allows the synthesis of the title compounds via four‐component condensation of ketones, aldehydes, malononitrile, and ammonium acetate.
ChemInform Abstract: Ultrasound Mediated, Green Innovation for the Synthesis of Polysubstituted 1,4‐Dihydropyridines.
Authors: Tabassum Sumaiya , Govindaraju Santhosh , Khan Riyaz‐ur‐Rahaman , Pasha M. A.
Published: July 2016

A series of novel polysubstituted 1,4‐dihydropyridines is synthesized via a one‐pot four‐component cyclocondensation reaction of aromatic aldehydes, malononitrile, acetylenedicarboxylates, and arylamines catalyzed by copper(I) iodide in aqueous medium under ultrasound irradiation.
ChemInform Abstract: Deep Eutectic Solvent Mediated Synthesis of Quinazolinones and Dihydroquinazolinones: Synthesis of Natural Products and Drugs.
Authors: Ghosh Suman Kr , Nagarajan Rajagopal
Published: July 2016

The title compounds are prepared by mild and green deep eutectic solvent mediated cyclization of substituted or unsubstituted anthranilamides with a wide range of aliphatic, aromatic, and heteroaromatic aldehydes in good to excellent yields.
ChemInform Abstract: Synthesis of 5,5′‐(Ethane‐1,2‐diyl)bis(3‐( (5‐bromo‐6‐methyl‐2‐tertiaryaminopyrimidin‐4‐yl)thio) ‐4H‐1,2,4‐triazol‐4‐amines) and Their Novel Bis‐Cyclized Products, 1,2‐Bis(pyrimido[5,4e][1,2,4] triazolo[3,4‐b][1,3,4]thiadiazin‐3‐yl)ethane, as Potential Inhibitors of 15‐Lipoxygenase.
Authors: Asghari Tayebe , Bakavoli Mehdi , Eshghi Hossein , Saberi Sattar , Ebrahimpour Zahra
Published: July 2016

All new compounds are evaluated in vitro as potential inhibitors of 15‐lipoxygenase (15‐LO).
ChemInform Abstract: Co(III)‐Catalyzed Synthesis of Quinazolines via C—H Activation of N‐Sulfinylimines and Benzimidates.
Authors: Wang Fen , Wang He , Wang Qiang , Yu Songjie , Li Xingwei
Published: July 2016

Both classes of title compounds are treated with dioxazolones as nitrile synthons since nitriles themselves fail to act as coupling partners in the synthesis.
ChemInform Abstract: Synthesis and Antitumor Activity Evaluation of Novel Substituted 5H‐Benzo[i][1,3,4]thiadiazolo[3,2‐a]quinazoline‐6,7‐diones.
Authors: Wu Liqiang , Zhang Chong
Published: July 2016

The title compounds are prepared by one‐pot condensation of hydroxynaphthoquinone, aldehydes, and aminothiadiazoles in moderate yields.
ChemInform Abstract: Synthesis and Biological Activity of Novel Ethyl Esters of 4‐R‐6,8‐Dimethyl‐1‐oxo‐1,2‐dyhidropyrrolo[1,2‐d] [1,2,4]triazine‐7‐carboxylic Acids.
Authors: Astakhina Valeriia , Voievudskyi Maxim , Kharchenko Olexander , Novikov Vladimir , Komarovska‐Porohnyavets Elena , Petukhova Olena
Published: July 2016

Compounds (III) and (VIIId,g,i) show weak in vitro anticancer activities against leukemia, melanoma, lung, colon, CNS, ovarian, renal, prostate, and breast cancer cell lines.
ChemInform Abstract: A Cascade Phosphinoylation/Cyclization/Desulfonylation Process for the Synthesis of 3‐Phosphinoylindoles.
Authors: Gao Yuzhen , Lu Guozhang , Zhang Pengbo , Zhang Liangliang , Tang Guo , Zhao Yufen
Published: July 2016

A wide range of substrates can be used for this operationally simple cascade annulation process to give 3‐phosphinoylindoles.
ChemInform Abstract: Phosphorothiolation of Aryl Boronic Acids Using P(O)H Compounds and Elemental Sulfur.
Authors: Xu Jian , Zhang Liangliang , Li Xueqin , Gao Yuzhen , Tang Guo , Zhao Yufen
Published: July 2016

Both ‐P(O)‐H and ‐P(S)‐H reactants can be used with success to afford a large variety of biologically interesting phosphorothioates and posphorodithioates in one step.
ChemInform Abstract: Aspterpenacids A and B, Two Sesterterpenoids from a Mangrove Endophytic Fungus Aspergillus terreus H010.
Authors: Liu Zhaoming , Chen Yan , Chen Senhua , Liu Yayue , Lu Yongjun , Chen Dongni , Lin Yongcheng , Huang Xishan , She Zhigang
Published: July 2016

The title compounds (Ia) and (Ib) possess a novel carbocyclic skeleton, represented by an unprecedented ring system.
ChemInform Abstract: New Antimalarial Norterpene Cyclic Peroxides from Xisha Islands Sponge Diacarnus megaspinorhabdosa.
Authors: Song Shao‐Jiang , et al.
Published: July 2016

Four new norterpene cyclic peroxides diacarnuperoxide M (Ia), diacarnuperoxide N (Ib), (+)‐2,3,6‐epihurghaperoxide (IIa), and (+)‐2,3,6‐epihurghaperoxide acid (IIb) are isolated from Xisha islands sponge Diacarnus megaspinorhabdosa together with three known norterpene cyclic peroxides.
ChemInform Abstract: Stereoselective Synthesis of Protected L‐ and D‐Dideoxysugars and Analogues via Prins Cyclizations.
Authors: Beattie Ryan J. , Hornsby Thomas W. , Craig Gemma , Galan M. Carmen , Willis Christine L.
Published: July 2016

The title synthesis from a novel and robust silicon‐acetal (II) and homoallylic alcohols [e.g. (I)] features high yields and excellent stereocontrol.
ChemInform Abstract: Reaction of Glyconitriles with Organometallic Reagents: Access to Acyl β‐C‐Glycosides.
Authors: Guisot Nicolas E. S. , Ella Obame Idriss , Ireddy Prathap , Nourry Arnaud , Saluzzo Christine , Dujardin Gilles , Dubreuil Didier , Pipelier Muriel , Guillarme Stephane
Published: July 2016

The formation of undesired glycals in this reaction is prevented by utilization of a free hydroxy group in position 2, which is deprotonated during the process.
ChemInform Abstract: Daldionin, an Unprecedented Binaphthyl Derivative, and Diverse Polyketide Congeners from a Fungal Orchid Endophyte.
Authors: Barnes Emma C. , Jumpathong Juangjun , Lumyong Saisamorn , Voigt Kerstin , Hertweck Christian
Published: July 2016

A series of constituents is isolated from the title species.
ChemInform Abstract: Long‐Chain Alkyl‐Substituted Gentisic Acid and Benzoquinone Derivatives from the Root of Micronychia tsiramiramy (Anacardiaceae).
Authors: Sewald Norbert , et al.
Published: July 2016

Two new compounds named micronyc acid (I) and micronone (II) are isolated together with four known compounds.
ChemInform Abstract: Bioactive Lignan Constituents from the Twigs of Sambucus williamsii.
Authors: Suh Won Se , Subedi Lalita , Kim Sun Yeou , Choi Sang Un , Lee Kang Ro
Published: July 2016

Three new lignan derivatives, sambucasinol A (I), sambucasinol B (II), and sambucasinol C (III), are isolated from the twigs of Sambucus williamsii together with 7 known compounds.
ChemInform Abstract: Layer Like Porous Materials with Hierarchical Structure
Authors: Roth Wieslaw J. , Gil Barbara , Makowski Waclaw , Marszalek Bartosz , Eliasova Pavla
Published: July 2016

Review: 324 refs.
ChemInform Abstract: Transport Properties of Hierarchical Micro—Mesoporous Materials
Authors: Schneider Daniel , Mehlhorn Dirk , Zeigermann Philipp , Kaerger Joerg , Valiullin Rustem
Published: July 2016

Review: 211 refs.
ChemInform Abstract: Analysis of the Magnetocaloric Effect in Powder Samples Obtained by Ball Milling
Authors: Blazquez J. S. , Ipus J. J. , Moreno‐Ramirez L. M. , Borrego J. M. , Lozano‐Perez S. , Franco V. , Conde C. F. , Conde A.
Published: July 2016

Review: 59 refs.
ChemInform Abstract: At the Forefront of the Suzuki‐Miyaura Reaction: Advances in Stereoselective Cross‐Couplings
Authors: Sun Ho‐Yan , Hall Dennis G.
Published: July 2016

Review: latest achievements in the development of stereoselective Suzuki‐Miyaura crosscoupling reactions; 101 refs.
ChemInform Abstract: Activated Nanostructured Bimetallic Catalysts for C—C Coupling Reactions: Recent Progress
Authors: Rai Rohit Kumar , Tyagi Deepika , Gupta Kavita , Singh Sanjay Kumar
Published: July 2016

Review: 127 refs.
ChemInform Abstract: Alkaloids and Isoprenoids Modification by Copper(I)‐Catalyzed Huisgen 1,3‐Dipolar Cycloaddition (Click Chemistry): Toward New Functions and Molecular Architectures
Authors: Kacprzak Karol , Skiera Iwona , Piasecka Monika , Paryzek Zdzislaw
Published: July 2016

Review: 244 refs.
ChemInform Abstract: 2‐Acetylphenothiazines as Synthon in Heterocyclic Synthesis
Authors: Gouda Moustafa A. , Hamama Wafaa S. , Kamal El‐din Hadwah A. , Zoorob Hanafi H.
Published: July 2016

Review: 66 refs.
ChemInform Abstract: Gold‐Catalyzed Carbene Transfer Reactions
Authors: Shin Seunghoon
Published: July 2016

Review: recent advances in the gold‐catalyzed oxygen atom transfer and carbene transfereactions to alkynes; 93 refs.
ChemInform Abstract: Oxime‐Derived Palladacycles: Applications in Catalysis
Authors: Najera Carmen
Published: July 2016

Review: catalytic activity of oxime‐derived palladacycles for alkenylation, cross‐coupling, alkynylation, carbonylation, annulation, α‐arylation, C—H activation, and oxime rearrangement reactions as well as their role as metalloenzymes in hydrolytic processes along with other applications in organic synthesis; 117 refs.
ChemInform Abstract: A Valuable Upgrade to the Portfolio of Cycloaddition Reactions
Authors: Walton John C.
Published: July 2016

Review: 19 refs.
ChemInform Abstract: BET Bromodomain as a Target of Epigenetic Therapy
Authors: Noguchi‐Yachide Tomomi
Published: July 2016

Review: 56 refs.
ChemInform Abstract: αvβ3‐ or α5β1‐Integrin‐Selective Peptidomimetics for Surface Coating
Authors: Mas‐Moruno Carlos , Fraioli Roberta , Rechenmacher Florian , Neubauer Stefanie , Kapp Tobias G. , Kessler Horst
Published: July 2016

Review: 137 refs + subrefs.
ChemInform Abstract: An Overview of Detection Techniques for Monitoring Dioxin‐Like Compounds: Latest Technique Trends and Their Applications
Authors: Tavakoly Sany Seyedeh Belin , Narimani Leila , Soltanian Faezeh Khalifeh , Hashim Rosli , Rezayi Majid , Karlen David J. , Mahmud H. N. M. Ekramul
Published: July 2016

Review: 117 refs.
ChemInform Abstract: Nonexponential 1H Spin‐Lattice Relaxation and Methyl Group Rotation in Molecular Solids
Authors: Beckmann Peter A.
Published: July 2016

Review: 82 refs.
ChemInform Abstract: 19F‐Detected 2‐D NMR of Multifluorinated Compounds
Authors: Wijmenga Sybren , Jaeger Martin
Published: July 2016

Review: 42 refs.
ChemInform Abstract: Automated Interpretation of NMR Spectra for Small Organic Molecules in Solution
Authors: Nuzillard Jean‐Marc
Published: July 2016

Review: 40 refs.
Sleep quality and its association with fatigue, symptom burden, and mood in patients with advanced cancer in a clinic for early‐phase oncology clinical trials
Authors: George Goldy C. , Iwuanyanwu Eucharia C. , Anderson Karen O. , Yusuf Alizeh , Zinner Ralph G. , Piha‐Paul Sarina A. , Tsimberidou Apostolia M. , Naing Aung , Fu Siqing , Janku Filip , Subbiah Vivek , Cleeland Charles S. , Mendoza Tito R. , Hong David S.
Published: July 2016

BACKGROUND

Limited data exist about sleep quality for patients with advanced cancer in phase 1 clinical trials. Poor sleep quality is often not captured as an adverse event, and its association with fatigue, one of the most frequently reported adverse events, is not documented routinely. This article describes sleep quality and its relation with fatigue, symptom burden, and mood in patients recruited from an early‐phase clinic for targeted therapy.

METHODS

Sleep, fatigue, symptom burden, and mood were assessed with the Pittsburgh Sleep Quality Index (PSQI), the Brief Fatigue Inventory, the MD Anderson Symptom Inventory (MDASI), and the Brief Profile of Mood States, respectively; the Eastern Cooperative Oncology Group (ECOG) performance status (PS) was determined from medical records.

RESULTS

The sample (n = 256) was 51.2% female, 90% had an ECOG PS of 0 or 1, and the mean age was 58 ± 0.8 years. Poor sleepers (global PSQI score > 5) constituted 64% of the sample. In separate multiple regression models, poor sleepers had higher levels of fatigue (P < .001), symptom burden (P < .001), and overall mood disturbance (P < .001) than good sleepers. Also, compared with good sleepers, poor sleepers had greater fatigue‐related and symptom‐related interference with daily activities (all P values < .001). The MDASI disturbed‐sleep item correlated well with the global PSQI score (Pearson's r = 0.679, P < .001), and this suggests its usefulness as a patient‐reported outcome screener of sleep quality in early‐phase clinical trials clinics.

CONCLUSIONS

Poor sleep quality was a significant problem in the current study and was associated with greater fatigue, symptom burden, and mood disturbance. Sleep quality should be routinely assessed in patients with advanced cancer who are participating in early‐phase clinical trials. Cancer 2016;122:3401–3409. © 2016 American Cancer Society.
Impact of optimization algorithms on hybrid indoor positioning based on GSM and Wi‐Fi signals
Authors: Machaj Juraj , Brida Peter
Published: July 2016

In the recent time indoor positioning becomes an extremely hot topic between researchers worldwide. This is mainly because of lack of available positioning solutions in the indoor environment and possibility to offer novel services based on location of users. Such services can also open new markets for service providers and thus increase their income. In this paper we will focus on application of optimization algorithms on performance of hybrid indoor positioning system, which utilize radio signals from both Global System for Mobile communication and Wi‐Fi networks simultaneously. The system is based on fingerprinting framework, which is widely used for indoor positioning because of its performance in strong multipath environment. Tests of the optimization algorithms were performed via simulations that were performed using simulation model created in Matlab environment. Copyright © 2016 John Wiley & Sons, Ltd.
Second harmonic generation properties of Ca3(O3C3N3)2 ‐Sr3(O3C3N3)2 solid solutions
Authors: Kalmutzki Markus , Wang Xiao , Meixner Alfred J. , Meyer Hans‐Jürgen
Published: July 2016

Solid solutions of the second harmonic generation (SHG) materials Ca3(O3C3N3)2 (CCY) and Sr3(O3C3N3)2 (SCY) were prepared via exothermic solid state metathesis reactions from appropriate amounts of the corresponding metal chlorides and potassium cyanate at 525 °C. The change in SHG intensity caused by the successive cation substitution is reported. Differential thermal analyses are used to explore the SCY–K(OCN) phase diagram as a medium for the growth of SCY crystals.
Genetic diversity and structuring across the range of a widely distributed ladybird: focus on rear‐edge populations phenotypically divergent
Authors: Lecompte Émilie , Bouanani Mohand‐Ameziane , Magro Alexandra , Crouau‐Roy Brigitte
Published: July 2016

Population genetics and phenotypic structures are often predicted to vary along the geographic range of a species. This phenomenon would be accentuated for species with large range areas, with discontinuities and marginal populations. We herein compare the genetic patterns of central populations of Coccinella septempunctata L. with those of two phenotypically differentiated populations considered as rear‐edge populations and subspecies based on phenotype (Algeria and Japan). According to the central‐marginal model and expected characteristics of rear‐edge populations, we hypothesize that these rear‐edge populations have (1) a reduced genetic diversity, resulting from their relative isolation over long periods of time, (2) a higher population genetic differentiation, explained by low contemporary gene flow levels, and (3) a relationship between genetic diversity characteristics and phenotypes, due to historical isolation and/or local adaptation. Based on genotyping of 28 populations for 18 microsatellite markers, several levels of regional genetic diversity and differentiation are observed between and within populations, according to their localization: low within‐population genetic diversity and higher genetic differentiation of rear‐edge populations. The genetic structuring clearly dissociates the Algerian and Eastern Asia populations from the others. Geographical patterns of genetic diversity and differentiation support the hypothesis of the central‐marginal model. The pattern observed is in agreement with the phenotypic structure across species range. A clear genetic break between populations of Algeria, the Eastern Asia, and the remaining populations is a dominant feature of the data. Differential local adaptations, absence of gene flow between marginal and central populations, and/or incapacity to mate after colonization, have contributed to their distinct genotypic and phenotypic characteristics.
Combinatorial Optimization Method Based on Hierarchical Structure in Solution Space
Authors: OCHIAI HIROKI , KANAZAWA TAKAHIKO , TAMURA KENICHI , YASUDA KEIICHIRO
Published: July 2016

In this paper, we introduce a new concept of hierarchical structure into solution space of a combinatorial optimization problem, and develop a novel combinatorial optimization method based on the concept. The introduction of the above new hierarchical structure concept “basin of attraction,” which is a set binding solution by utilizing properties of local optimal solutions, enables us to construe solution space as not only set of solutions but also set of basins of attraction hierarchically. It is well known that the appropriate balance of two policies, intensification and diversification, is essential in the search of metaheuristics. The proposed method clarifies the search policy by relating the hierarchical structure in solution space with intensification and diversification. With regard to diversification, we incorporate a movement strategy that has longer term or more macroscopic viewpoint than before in the algorithm by utilizing the concept basin of attraction. The performance of the proposed combinatorial optimization method is inspected by numerical experiments using some typical benchmark problems of a traveling salesman problem, a knapsack problem, a flow‐shop scheduling problem, and a quadratic assignment problem.
Stereoselective Synthesis of (+)‐Petromyroxol
Authors: Reddy Vulupala Veerabhadra , Reddy Basi V. Subba
Published: July 2016

The stereoselective total synthesis of (+)‐petromyroxol, isolated from the water conditioned with the larval sea lamprey has been accomplished by employing the cross‐metathesis, tandem Sharpless asymmetric dihydroxylation/SN2 cyclization, and regioselective ring opening of epoxide as the key steps.
Early onset pancreatic malignancies: Clinical characteristics and survival associations
Authors: Beeghly‐Fadiel Alicia , Luu Hung N. , Du Liping , Shi Chanjuan , McGavic Dauphne P. , Parikh Alexander A. , Raskin Leon
Published: July 2016

Diagnosed before age 50, early onset pancreatic malignancy (EOPM), is hypothesized to be a distinct subset of disease, although research is limited. To better characterize EOPM, and the effect of age at diagnosis on pancreatic cancer survival, we examined clinical characteristics and survival in EOPM and typical age‐at‐onset pancreatic malignancy (TOPM) cases. Vanderbilt University Medical Center (VUMC) Cancer Registry confirmed pancreatic adenocarcinomas (PDACs) and malignant pancreatic neuroendocrine tumors (PNETs) were evaluated. Clinical characteristics were compared using χ2 tests. Overall survival was visualized with Kaplan–Meier functions; Cox proportional hazards regression was used to evaluate hazard ratios (HRs) and 95% confidence intervals (CIs). A total of 1,697 pancreatic malignancies were diagnosed at the VUMC between 1988 and 2013. Of 1,407 PDACs, 118 (8.4%) were EOPM, which was associated with significantly better survival (adjusted HR: 0.82, 95% CI: 0.67–1.00). EOPM and TOPM PDACs significantly differed with regard to having multiple malignancies; survival associations significantly differed by race, stage of disease, treatment and multiple malignancies. Of 190 PNETs, 63 (33.1%) were EOPM, which was not significantly associated with survival (adjusted HR: 0.80, 95% CI: 0.46–1.40). Malignant neuroendocrine EOPM and TOPM cases significantly differed by stage of disease and tumor location; survival associations significantly differed by family history of pancreatic cancer, stage of disease and multiple malignancies. Differences in clinical characteristics and associations with survival were identified, indicating that EOPM is distinct from TOPM, and exists among both pancreatic adenocarcinomas and malignant pancreatic neuroendocrine tumors.
Holocene delta evolution and sediment flux of the Pearl River, southern China
Authors: Wei Xing , Wu Chaoyu , Ni Peitong , Mo Wenyuan
Published: July 2016

Delta progradation and sediment flux of the Pearl River Delta (PRD), southern China, during the Holocene are presented based on analyses of borehole data on the delta plain. Results indicate that the delta prograded into the drowned valley because of early Holocene inundation from 9 to 6 cal ka BP, as sea‐level rise decelerated. The sea level reached its present level at about 6 cal ka BP and, as a consequence, a large portion of the drowned valley was covered by the estuary, with more than 160 rock islands and platforms. The scattered landmasses promoted active deposition and acted as deposition nuclei during deltaic evolution. Consequently, apart from exhibiting a general tendency towards progression, PRD development occurred less regularly over time and space because of deposition around island boundaries. During the last 2 ka, mainly because of significantly increased human activities, which have trapped sediments in the encircled tidal flats along the front of delta plains, the shoreline has advanced rapidly. Estimated sediment fluxes for the three periods (9–6, 6–2 and 2–0 cal ka BP), based on the sediment volume analysis, were 17–25, 22–30 and 44–58 million t a−1, respectively.
Multimodality assessment of upper airway obstruction in children with persistent obstructive sleep apnea after adenotonsillectomy
Authors: Clark Christopher , Ulualp Seckin O.
Published: July 2016

Objectives/Hypothesis

Children with obstructive sleep apnea (OSA) may have multiple sites of upper airway obstruction (UAO). A wide variety of techniques has been used to evaluate UAO. Our aim was to compare findings of cine magnetic resonance imaging (MRI) and drug‐induced sleep endoscopy (DISE) in identifying UAO sites in children with persistent OSA after adenotonsillectomy (AT).

Study Design

Retrospective chart review.

Material and Methods

The medical records of children who underwent DISE and cine MRI were reviewed. Data pertaining to demographics, past medical history, body mass index, polysomnography, findings of DISE, and cine MRI were obtained.

Results

Fifteen children (11 boys, 4 girls; age range, 7–18 years) were identified. Comorbid conditions were Down syndrome in nine patients, cerebral palsy in one, attention deficit hyperactivity disorder in two, and asthma in three. Severity of OSA was moderate in five, and severe in 10. DISE and cine MRI showed the same UAO site in 10 patients: a single site (tongue) in nine and multiple sites (tongue and oropharynx/lateral walls) in one. DISE showed additional UAO sites undetected by cine MRI in three patients. Cine MRI showed additional UAO sites undetected by DISE in one patient. DISE and cine MRI showed different sites of obstruction in one patient.

Conclusions

Cine MRI and DISE documented single and multiple sites of UAO in children with persistent OSA after AT. Cine MRI and DISE findings were similar in the majority of the children. Assessment of the sensitivity and specificity of cine MRI and DISE in detecting sites of UAO merits further investigation.

Level of Evidence

4. Laryngoscope, 127:1224–1230, 2017
Investigation into the presence of human papillomavirus in patients with obstructive sleep apnea
Authors: Baldwin Brett J. , Chitale Dhananjay , Chen Kang Mei , Worsham Maria J. , Yaremchuk Kathleen
Published: July 2016

Objectives/Hypothesis

The human papillomavirus (HPV) is known to infect the tissues of the oropharynx as demonstrated in HPV‐positive oropharyngeal squamous cell carcinoma (OPSCC). HPV has also been shown to induce benign lymphoid hypertrophy. We sought to investigate an association between obstructive sleep apnea (OSA) and the presence of HPV in palatine and lingual tonsillar oropharyngeal tissue.

Study Design

Case series with chart review.

Methods

This retrospective laboratory‐based study of oropharyngeal tissue from patients with OSA included patients >18 years old who underwent surgical treatment for OSA at a single institution between January 2012 and May 2014. Surgical specimens of adequate size were analyzed for HPV6, 11, and 16 using real‐time quantitative polymerase chain reaction from DNA extracted from formalin‐fixed paraffin‐embedded tissue blocks. Student t test, Pearson χ2 test, and linear logistic regression were used to assess comparisons of body mass index (BMI), apnea‐hypopnea index (AHI), age, and gender between HPV‐positive and HPV‐negative groups.

Results

Of 99 cases included in the study, six were positive for HPV: two with HPV16 and four with HPV6. BMI, AHI, age, and gender showed no significant differences between the HPV‐positive and HPV‐negative groups. Logistic regression to predict HPV positivity accounting for each variable and multivariate analysis were not statistically significant.

Conclusions

Our study did not show HPV to have a statistically significant association with OSA. None of the covariates analyzed (BMI, AHI, gender, age) predicted HPV positivity in surgically resected oropharyngeal tissue from OSA patients.

Level of Evidence

4 Laryngoscope, 127:1231–1234, 2017
Microbial Cells with a Fe3O4 Doped Hydrogel Extracellular Matrix: Manipulation of Living Cells by Magnetic Stimulus
Authors: Shi Xudian , Shi Zhijun , Wang Daming , Ullah Muhammad Wajid , Yang Guang
Published: July 2016

This study aims to develop an effective method to control motile microorganisms and enable their manipulation as functional ‘live micro/nano robots'. A novel strategy based on Fe3O4 nanoparticle‐doped alginate hydrogel is developed to fashion an artificial extracellular matrix (ECM) for microbial cells (e.g., Saccharomyces cerevisiae and Flavobacterium heparinum). During this strategy, a single layer of alginate hydrogel is coated around the microbial cells doped with Fe3O4 nanoparticles to form the alg‐mag‐cells. Transmission electron microscopy shows that Fe3O4 nanoparticles are uniformly distributed in the hydrogel shell. Together with maintaining the cell activity and metabolism, the hydrogel coated microbial cells demonstrate high magnetic responsiveness in an external magnetic field and are able to form micro‐scaled patterns using the magnetic template designed in this study. This strategy provides a building block to fabricate advanced biological models, medical therapeutic products, and non‐medical biological systems using different microorganisms.

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Effect of blastocoel fluid reduction before vitrification on gene expression in mouse blastocysts
Authors: Kazemi Parinaz , Dashtizad Mojtaba , Shamsara Mehdi , Mahdavinezhad Forough , Hashemi Ehsan , Fayazi Samaneh , Hajarian Hadi
Published: July 2016

Artificial collapse of the blastocoel cavity before vitrification can improve the quality of warmed embryos, yet how reduction of blastocoel fluid impacts formation of the blastocyst cell lineages is not clear. The present study assessed the effect of pre‐vitrification blastocoel fluid reduction on the survival, hatching rate, and the expression of genes related to apoptosis (Tp53), pluripotency (Pou5f1, Nanog), and differentiation (Cdx2, Eomes, Gata6) in mouse blastocysts. In vivo‐produced blastocysts were randomly divided into three groups: The first group was vitrified and warmed; the second group underwent artificial collapse of the blastocoel cavity prior to vitrification and warming; the third group served as the control, in which neither vitrification or artificial collapse was performed. The survival rate of treatment groups was similar to the control group, whereas the hatching rate of artificial collapse/vitrified blastocysts was significantly higher than vitrified blastocysts. Quantitative reverse‐transcription PCR analysis revealed a considerable reduction in the expression of Cdx2, Eomes, Gata6, Grb2, and Tp53 transcripts following artificial collapse/vitrification in comparison to the vitrification‐alone group; the abundance of Pou5f1 and Nanog, however, did not change. These results suggest that artificial collapse of the blastocoel cavity before vitrification leads to relatively normal expression of apoptosis and development‐related genes plus higher hatching rates. Mol. Reprod. Dev. 83: 735–742, 2016 © 2016 Wiley Periodicals, Inc.
Calculating the internodal transmissibilities using finite analytic method and its application for multi‐phase flow in heterogeneous porous media
Authors: Zheng X.‐L. , Liu Z.‐F. , Wang X.‐H. , Shi A.‐F.
Published: July 2016

In the traditional numerical reservoir simulations, the internodal transmissibility is usually defined as the harmonic mean of the permeabilities of the adjacent grids. This definition underestimates the phase flux and the speed of the saturation front, especially for the strong heterogeneous case. In this article, the internodal transmissibility is recalculated according to the nodal analytic solution. The redefined internodal transmissibility can be used directly to calculate the multiphase flow in the numerical reservoir simulations. Numerical examples show that, compared to the traditional numerical methods, the proposed scheme makes the convergences much faster as the refinement parameter increases, and the accuracy is independent of the heterogeneity. Copyright © 2016 John Wiley & Sons, Ltd.
Predicting fatigue damage in interphase of short fiber reinforced rubber composites under transverse load
Authors: Chen Lili , Gu Boqin
Published: July 2016

A computational model has been established for analyzing the interphase damage of short fiber reinforced rubber composites (SFRCs) under transverse static and fatigue tensile loads. A cohesive zone model was integrated with a stress‐based fatigue damage model to simulate the damage initiation and propagation. To obtain the damage model parameters and validate the methodology, some tests of SFRCs under static and fatigue tensile loads were conducted. The simulation results agree well with the experimental data. It is observed that under static loads, the damage of SFRCs is dominated by the interphase damage before the strain reaches 38.04%. Under fatigue loads, the speed of damage propagation increases exponentially with cyclic numbers. Once the crack in the interphase is initiated, it extends to almost the entire interphase after several cycles because of the stress concentration near the crack tip. It is found that a good initial adhesion status of the interphase can effectively improve the antifatigue performance of SFRCs. POLYM. COMPOS., 39:1455–1467, 2018. © 2016 Society of Plastics Engineers