bluuebunny/crossref_metadata_2025 huggingface dataset:
Association between PHOX2B gene rs28647582 T>C polymorphism and Wilms tumor susceptibility
Authors: Lin Ao , Fu Wen , Wang Wenwen , Zhu Jinhong , Liu Jiabin , Xia Huimin , Liu Guochang , He Jing
Published: October 2019

Wilms tumor is one of the most common pediatric solid tumors. The pair-like homeobox 2b (PHOX2B) gene is an important transcription factor that regulates cellular proliferation and differentiation in early life. The association between PHOX2B single nucleotide polymorphisms (SNPs) and Wilms tumor risk has not been investigated. Therefore, we conducted a case-control study involving 145 Wilms tumor patients and 531 controls to explore the association between the PHOX2B rs28647582 T>C polymorphism and Wilms tumor susceptibility. The association between the PHOX2B rs28647582 T>C polymorphism and Wilms tumor susceptibility was assessed by odds ratios (ORs) and 95% confidence intervals (CIs). Our results indicated that PHOX2B rs28647582 T>C polymorphism did not significantly alter Wilms tumor susceptibility. However, in the stratified analysis, we found that TC/CC genotypes significantly increased Wilms tumor risk among children older than 18 months (adjusted OR = 1.77, 95% CI = 1.07–2.95, P=0.027) and those with clinical stages III+IV (adjusted OR = 1.75, 95% CI = 1.09–2.82, P=0.022), when compared with those with TT genotype. Our study suggested that PHOX2B rs28647582 T>C was weakly associated with Wilms tumor susceptibility. Our conclusions need further validation with a larger sample size.
Particulate matter exposure aggravates osteoarthritis severity
Authors: Peng Kuo-Ti , Liu Ju-Fang , Chiang Yao-Chang , Chen Pei-Chun , Chiang Ming-Hsien , Shih Hsin-Nung , Chang Pey-Jium , Lee Chiang-Wen
Published: October 2019

Several diseases have been linked to particulate matter (PM) exposure. Outdoor activities, such as road running or jogging, are popular aerobic exercises due to few participatory limitations. Osteoarthritis (OA) is a progressive degenerative joint disease, usually observed at age 40, and not noticed before pain or diagnosis. Although exercise has health benefits, it is unclear whether outdoor jogging in higher PM (standard reference material 1649b, SRM 1649b) concentration environments could affect OA development or severity. Hence, a PM exposure monosodium iodoacetate (MIA)-induced OA animal jogged model was established for investigation. Results showed that high doses of PM (5 mg) significantly increased pro-inflammatory factors such as tumor necrosis factor α (TNF-α), interleukin (IL)-1β, and IL-6, and M1 macrophages in the lung region, also obtained in systemic IL-6 and TNF-α expressions in this MIA-OA rat model. Moreover, levels of osteocalcin, cartilage oligomeric matrix protein (COMP), and N-telopeptides of type I collagen were especially influenced in MIA+PM groups. Morphological and structural changes of the knee joint were detected by micro-computed tomography images (micro-CT) and immunohistochemistry. MIA + PM rats exhibited severe bone density decrease, cartilage wear, and structure damages, accompanied by lower levels of physical activity, than the sham group and groups receiving MIA or PM alone. The findings suggest that the severity of OA could be promoted by PM exposure with a PM concentration effect via systemic inflammatory mechanisms. To the best of our knowledge, this is the first study to provide direct effects of PM exposure on OA severity.
Lack of adipose-specific hexose-6-phosphate dehydrogenase causes inactivation of adipose glucocorticoids and improves metabolic phenotype in mice
Authors: Wang Jian , Wang Ying , Liu Limei , Lutfy Kabirullah , Friedman Theodore C. , Liu Ya , Jiang Meisheng , Liu Yanjun
Published: October 2019

Excessive glucocorticoid (GC) production in adipose tissue promotes the development of visceral obesity and metabolic syndrome (MS). 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) is critical for controlling intracellular GC production, and this process is tightly regulated by hexose-6-phosphate dehydrogenase (H6PDH). To better understand the integrated molecular physiological effects of adipose H6PDH, we created a tissue-specific knockout of the H6PDH gene mouse model in adipocytes (adipocyte-specific conditional knockout of H6PDH (H6PDHAcKO) mice). H6PDHAcKO mice exhibited almost complete absence of H6PDH expression and decreased intra-adipose corticosterone production with a reduction in 11β-HSD1 activity in adipose tissue. These mice also had decreased abdominal fat mass, which was paralleled by decreased adipose lipogenic acetyl-CoA carboxylase (ACC) and ATP-citrate lyase (ACL) gene expression and reduction in their transcription factor C/EBPα mRNA levels. Moreover, H6PDHAcKO mice also had reduced fasting blood glucose levels, increased glucose tolerance, and increased insulin sensitivity. In addition, plasma free fatty acid (FFA) levels were decreased with a concomitant decrease in the expression of lipase adipose triglyceride lipase (ATGL) and hormone-sensitive lipase (HSL) in adipose tissue. These results indicate that inactivation of adipocyte H6PDH expression is sufficient to cause intra-adipose GC inactivation that leads to a favorable pattern of metabolic phenotypes. These data suggest that H6PDHAcKO mice may provide a good model for studying the potential contributions of fat-specific H6PDH inhibition to improve the metabolic phenotype in vivo. Our study suggests that suppression or inactivation of H6PDH expression in adipocytes could be an effective intervention for treating obesity and diabetes.
Rotational evolution of solar-type protostars during the star-disk interaction phase
Authors: Gallet F. , Zanni C. , Amard L.
Published: October 2019

Context. The early pre-main sequence phase during which solar-mass stars are still likely surrounded by an accretion disk represents a puzzling stage of their rotational evolution. While solar-mass stars are accreting and contracting, they do not seem to spin up substantially.

Aims. It is usually assumed that the magnetospheric star-disk interaction tends to maintain the stellar rotation period constant (“disk-locking”), but this hypothesis has never been thoroughly verified. Our aim is to investigate the impact of the star-disk interaction mechanism on the stellar spin evolution during the accreting pre-main sequence phases.

Methods. We devised a model for the torques acting on the stellar envelope based on studies of stellar winds, and we developed a new prescription for the star-disk coupling founded on numerical simulations of star-disk interaction and magnetospheric ejections. We then used this torque model to follow the long-term evolution of the stellar rotation.

Results. Strong dipolar magnetic field components up to a few kG are required to extract enough angular momentum so as to keep the surface rotation rate of solar-type stars approximately constant for a few Myr. Furthermore an efficient enough spin-down torque can be provided by either one of the following: a stellar wind with a mass outflow rate corresponding to ≈10% of the accretion rate, or a lighter stellar wind combined with a disk that is truncated around the corotation radius entering a propeller regime.

Conclusions. Magnetospheric ejections and accretion powered stellar winds play an important role in the spin evolution of solar-type stars. However, kG dipolar magnetic fields are neither uncommon or ubiquitous. Besides, it is unclear how massive stellar winds can be powered while numerical models of the propeller regime display a strong variability that has no observational confirmation. Better observational statistics and more realistic models could contribute to help lessen our calculations’ requirements.
A simple two-component description of energy equipartition and mass segregation for anisotropic globular clusters
Authors: Torniamenti S. , Bertin G. , Bianchini P.
Published: October 2019

In weakly-collisional stellar systems such as some globular clusters, partial energy equipartition and mass segregation are expected to develop as a result of the cumulative effect of stellar encounters, even in systems initially characterized by star-mass independent density and energy distributions. In parallel, numerical simulations have demonstrated that radially-biased pressure anisotropy slowly builds up in realistic models of globular clusters from initial isotropic conditions, leading to anisotropy profiles that, to some extent, mimic those resulting from incomplete violent relaxation known to be relevant to elliptical galaxies. In this paper, we consider a set of realistic simulations realized by means of Monte Carlo methods and analyze them by means of self-consistent, two-component models. For this purpose, we refer to an underlying distribution function originally conceived to describe elliptical galaxies, which has recently been truncated and adapted to the context of globular clusters. The two components are supposed to represent light stars (combining all main sequence stars) and heavy stars (giants, dark remnants, and binaries). We show that this conceptually simple family of two-component truncated models provides a reasonable description of simulated density, velocity dispersion, and anisotropy profiles, especially for the most relaxed systems, with the ability to quantitatively express the attained levels of energy equipartition and mass segregation. In contrast, two-component isotropic models based on the King distribution function do not offer a comparably satisfactory representation of the simulated globular clusters. With this work, we provide a new reliable diagnostic tool applicable to nonrotating globular clusters that are characterized by significant gradients in the local value of the mass-to-light ratio, beyond the commonly used one-component dynamical models. In particular, these models are supposed to be an optimal tool for the clusters that underfill the volume associated with the boundary surface determined by the tidal interaction with the host galaxy.
Interferometric observations of warm deuterated methanol in the inner regions of low-mass protostars
Authors: Taquet V. , Bianchi E. , Codella C. , Persson M. V. , Ceccarelli C. , Cabrit S. , Jørgensen J. K. , Kahane C. , López-Sepulcre A. , Neri R.
Published: October 2019

Methanol is a key species in astrochemistry because it is the most abundant organic molecule in the interstellar medium and is thought to be the mother molecule of many complex organic species. Estimating the deuteration of methanol around young protostars is of crucial importance because it highly depends on its formation mechanisms and the physical conditions during its moment of formation. We analyse several dozen transitions from deuterated methanol isotopologues coming from various existing observational datasets obtained with the IRAM-PdBI and ALMA sub-millimeter interferometers to estimate the methanol deuteration surrounding three low-mass protostars on Solar System scales. A population diagram analysis allows us to derive a [CH2DOH]/[CH3OH] abundance ratio of 3–6% and a [CH3OD]/[CH3OH] ratio of 0.4–1.6% in the warm inner (≤100–200 AU) protostellar regions. These values are typically ten times lower than those derived with previous single-dish observations towards these sources, but they are one to two orders of magnitude higher than the methanol deuteration measured in massive hot cores. Dust temperature maps obtained from Herschel and Planck observations show that massive hot cores are located in warmer molecular clouds than low-mass sources, with temperature differences of ~10 K. The comparison of our measured values with the predictions of the gas-grain astrochemical model GRAINOBLE shows that such a temperature difference is sufficient to explain the different deuteration observed in low- to high-mass sources. This suggests that the physical conditions of the molecular cloud at the origin of the protostars mostly govern the present-day observed deuteration of methanol and therefore of more complex organic molecules. Finally, the methanol deuteration measured towards young solar-type protostars on Solar System scales seems to be higher by a factor of ~5 than the upper limit in methanol deuteration estimated in comet Hale-Bopp. If this result is confirmed by subsequent observations of other comets, it would imply that an important reprocessing of the organic material likely occurred in the solar nebula during the formation of the Solar System.
ALMA observations of PKS 1549–79: a case of feeding and feedback in a young radio quasar
Authors: Oosterloo Tom , Morganti Raffaella , Tadhunter Clive , Raymond Oonk J. B. , Bignall Hayley E. , Tzioumis Tasso , Reynolds Cormac
Published: October 2019

We present CO(1−0) and CO(3−2) Atacama Large Millimeter/submillimeter Array observations of the molecular gas in PKS 1549−79, as well as mm and very long baseline interferometry 2.3-GHz continuum observations of its radio jet. PKS 1549−79 is one of the closest young, radio-loud quasars caught in an on-going merger in which the active galactic nucleus (AGN) is in the first phases of its evolution. We detect three structures tracing the accretion and the outflow of molecular gas: kpc-scale tails of gas accreting onto PKS 1549−79 from a merger, a circumnuclear disc in the inner few hundred parsec, and a very broad (> 2300 km s−1) component detected in CO(1−0) at the position of the AGN. Thus, in PKS 1549−79 we see the co-existence of accretion and the ejection of gas. The line ratio CO(3−2)/CO(1−0) suggests that the gas in the circumnuclear-disc has both high densities and high kinetic temperatures. We estimate a mass outflow rate of at least 650 M⊙ yr−1. This massive outflow is confined to the inner region (r <  120 pc) of the galaxy, which suggests that the AGN drives the outflow. Considering the amount of molecular gas available in the central nuclear disc and the observed outflow rate, we estimate a time scale of ∼105 yr over which the AGN would be able to destroy the circumnuclear disc, although gas from the merger may come in from larger radii, rebuilding this disc at the same time. The AGN appears to self-regulate gas accretion to the centre and onto the super-massive black hole. Surprisingly, from a comparison with Hubble Space Telescope data, we find that the ionised gas outflow is more extended. Nevertheless, the warm outflow is about two orders of magnitude less massive than the molecular outflow. PKS 1549−79 does not seem to follow the scaling relation between bolometric luminosity and the relative importance of warm ionised and molecular outflows claimed to exist for other AGN. We argue that, although PKS 1549−79 hosts a powerful quasar nucleus and an ultra-fast outflow, the radio jet plays a significant role in producing the outflow, which creates a cocoon of disturbed gas that expands into the circumnuclear disc.
Update on the hadronic vacuum polarisation contributions to muon g − 2 and α(mZ2)
Authors: Zhang Zhiqing
Published: October 2019

An update of the hadronic vacuum polarisation contributions to the muon magnetic anomaly and to the running of the electromagnetic couplings constant at the Z-boson mass is presented. Newest e+e−→ hadrons cross-section data mainly from the BABAR and VEPP-2000 experiments have been included. For the muon (g−2)/2, the lowest-order hadronic contribution is evaluated to be (693.1 ± 3.4) · 10−10, improving the precision of our previous evaluation by 21%. The full Standard Model prediction diﬀers by 3.5 σ from the experimental value. The five-quark hadronic contribution to $ \alpha (\mathop m\nolimits_z^2 ) $ is evaluated to be (276.0 ± 0.9) · 10−4.
Overview of SND hadronic cross section measurements
Authors: Dimova T.V. , Achasov M.N. , Aulchenko V.M. , Barnyakov A.Yu. , Beloborodov K.I. , Berdyugin A.V. , Berkaev D.E. , Bogdanchikov A.G. , Botov A.A. , Druzhinin V.P. , Ganeev E.B. , Golubev V.B. , Kardapoltsev L.V. , Kasaev A.S. , Kharlamov A.G. , Kirpotin A.N. , Koop I.A. , Korneev L.A. , Korol A.A. , Koshuba S.V. , Kovrizhin D.P. , Kupich A.S. , Litvinov R.A. , Martin K.A. , Melnikova N.A. , Muchnoi N.Yu. , Obrazovsky A.E. , Pakhtusova E.V. , Pugachev K.V. , Rogovsky Yu.A. , Rogozina E.V. , Serednyakov S.I. , Senchenko A.I. , Shtol D.A. , Shwartz D.B. , Silagadze Z.K. , Surin I.K. , Usov Yu.V. , Vasiljev A.V. , Zhabin V.N.
Published: October 2019

At the end of 2016 the SND detector resumed data taking at the upgraded VEPP-2000 e+e− collider. The analysis of data accumulated in 2010-2013 with an integrated lumonosity of 70 pb−1 is continuing. Recent results on measurements of various hadronic cross sections are presented.
Initial State Radiation Measurements at BESIII
Authors: Ripka Martin
Published: October 2019

Precision measurements of the hadronic cross sections e+ e−→ π+ π− , π+π−π0, π+π−2π0, ωπ0 and π+π−3π0 are performed at the BESIII experiment located in Beijing, China. These cross section measurements are needed as input for the Standard Model prediction of the anomalous magnetic moment of the muon, (g − 2)µ.The initial state radiation method is used to access the energy regions of interest for (g − 2)µ. Our results will improve the precision of the Standard Model prediction of (g − 2)µ .
Study of the processes e+e-→ K+K− + nπ (n = 1,2,3) with the CMD-3 detector at the VEPP-2000 electron-positron collider
Authors: Fedotovich G.V. , Akhmetshin R.R. , Amirkhanov A.N. , Anisenkov A.V. , Aulchenko V.M. , Banzarov V.S. , Bashtovoy N.S. , Berkaev D.E. , Bondar A.E. , Bragin A.V. , Eidelman S.I. , Epifanov D.A. , Epshteyn L.B. , Erofeev A.L. , Gayazov S.E. , Grebenuk A.A. , Gribanov S.S. , Grigoriev D.N. , Ignatov F.V. , Ivanov V.L. , Karpov S.V. , Kasaev A.S. , Kazanin V.F. , Korobov A.A. , Koop I.A. , Kozyrev A.N. , Kozyrev E.A. , Krokovny P.P. , Kuzmenko A.E. , Kuzmin A.S. , Logashenko I.B. , Lukin P.A. , Lysenko A.P. , Mikhailov K.Yu. , Okhapkin V.S. , Perevedentsev E.A. , Pestov Yu.N. , Popov A.S. , Razuvaev G.P. , Rogovsky Yu.A. , Ruban A.A. , Ryskulov N.M. , Ryzhenenkov A.E. , Shebalin V.E. , Shemyakin D.N. , Shwartz B.A. , Shwartz D.B. , Sibidanov A.L. , Shatunov Yu.M. , Solodov E.P. , Talyshev A.A. , Vorobiov A.I. , Yudin Yu.V. , Zemlyansky I.M.
Published: October 2019

The data sample collected in 2011-2013 at the c.m.s. energies between 0.32-2 GeV with the CMD-3 detector operating at the VEPP-2000 e+e− collider is analzed. The collected data corresponds to an integrated luminosity about ∼ 60pb−1. The techniques for determination of the integrated luminosity for each energy setting is described. Some preliminary results of the study of the processes e+e−→ K+ K− + nπ (n = 1,2,3) with two charged kaons in the final state are presented. These processes have several intermediate states, which are important to correctly descript the angular distributions of final particles and the cross sections dependence on the energy.
Measurement of the running of the fine structure constant below 1 GeV with the KLOE detector
Authors: Venanzoni Graziano
Published: October 2019

I will report on the recent measurement of the fine structure constant below 1 GeV with the KLOE detector. It represents the first measurement of the running of α(s) in this energy region. Our results show a more than 5σ significance of the hadronic contribution to the running of α(s), which is the strongest direct evidence both in time-and space-like regions achieved in a single measurement. From a fit of the real part of Δα(s) and assuming the lepton universality the branching ratio BR(ω → µ+µ−) = (6.6 ± 1.4stat ± 1.7syst) · 10−5 has been determined
Measurement of transition form factors in two-photon collisions at BESIII
Authors: Redmer Christoph Florian
Published: October 2019

The two-photon physics program of the BESIII Collaboration is mainly motivated by the need of new measurements of transition form factors as input for the Standard Model calculations of $ \mathop a\nolimits_\mu ^{HLbL} $, the hadronic light-by-light scattering contribution to the anomalous magentic moment of the muon. The large data sets acquired at BESIII allow to study the transition form factors of pseudoscalar mesons in the relevant region of momentum transfer for $ \mathop a\nolimits_\mu ^{HLbL} $. In this presentation the status of the respective measurements for π0,η and η’ mesons are discussed, and prospects for studies of multi-meson systems as well as of doubly-virtual transition form factors are given.
ISR Experiment at A1-Collaboration
Authors: Mihovilovič Miha , Merkel Harald
Published: October 2019

The discrepancy between the proton charge radius extracted from the muonic hydrogen Lamb shift measurement and the best present value obtained from the elastic scattering experiments, remains unexplained and represents a burning problem of today’s nuclear physics. In a pursuit of reconciling the puzzle an experiment is underway at MAMI, which exploits the radiative tail of the elastic peak to study the properties of electromagnetic processes and to extract the proton charge form factor $ \left( {\mathop G\nolimits_E^p } \right) $ at extremely small Q2. This paper reports on the latest results of the first such measurement performed at the three-spectrometer facility of the A1-Collaboration, which led to a precise validation of radiative corrections far away from elastic line and provided measurements of $ \mathop G\nolimits_E^p $ for 0.001 ≤ Q2 ≤ 0.017 (GeV/c)2.
Nucleon form factors at threshold
Authors: Milstein Alexandr
Published: October 2019

The pp¯invariant mass spectra in the processes e+e−→ pp¯, e+e−→ nn¯, J/ψ → pp¯ω, J/ψ → pp¯ρ, and J/ψ → pp¯γ close to the pp¯is discussed. The optical potentials for NN¯pair in the superposition of S and D waves (due to tensor forces) at spin unity of the pair, as well as for NN¯pair in the S wave at spin zero of the pair, are proposed. The parameters of the potentials are obtained by fitting the cross sections of NN¯scattering together with the pp¯invariant mass spectra in e+e−→ pp¯annihilation and J/ψ decays. Good agreement with the available experimental data is achieved. Using our potential and the Green’s function approach we also describe the cross section of e+ e−→ 6π and the η’π+ π− invariant mass spectrum in the decay J/ψ → γη’π+π− in the energy region near the NN¯threshold.
Status and progress of the HFLAV-Tau group activities
Authors: Lusiani Alberto
Published: October 2019

We report the status and progress of the Heavy Flavour Averaging Group work on the global fit of τ tau lepton branching fractions, on the lepton universality tests and on the measurement of the Cabibbo-Kobayashi-Maskawa matrix element |Vus| using τ lepton measurements. We also review the prospects for improving the precision of the |Vus| measurement.
Dark Photon Studies atBABAR
Authors: Filippi Alessandra
Published: October 2019

An overview of the most recent results byBABARon the search of dark photon and dark sector gauge bosons is presented, with larger emphasis on dark photon decays in invisible channels and searches for muonic dark force.
Jefferson Lab Report
Authors: Chudakov Eugene
Published: October 2019

Jefferson Laboratory is finishing a major upgrade and has already started operations with the 12 GeV continuous electron beam. The main research direction is the study of the structure of hadrons, including a search for gluon excitations in the spectra of light mesons and baryons, and studies of multidimensional images of the nucleon. Studied of certain properties of atomic nuclei are also ongoing. There is also an active program of searching for effects beyond the Standard Model in parity-violating electron scattering, as well as a search for new particles.
The Belle II Experiment at the SuperKEKB
Authors: Yuan Chang-Zheng
Published: October 2019

Belle II experiment at the SuperKEKB collider is a major upgrade of the Belle experiment at the KEKB asymmetric e+e− collider at the KEK. The experiment will focus on the search for new physics beyond the standard model via high precision measurement of heavy flavor decays and search for rare signals. In this talk, we present the status of the SuperKEKB collider and the Belle II detector.
Status of the BabaYaga event generator
Authors: Carloni Calame Carlo M. , Montagna Guido , Nicrosini Oreste , Piccinini Fulvio
Published: October 2019

The Monte Carlo event generator BabaYaga has been developed for high precision simulation of QED processes (e+e−→ e+ e− , e+e−→ µ+µ− and e+e−→ γγ) at flavour factories, chiefly for luminometry purposes, with an estimated theoretical accuracy at the 0.1% level or better. QED radiative corrections are included by means of a Parton Shower in QED matched with exact next-to-leading order corrections to reach the required accuracy. The latter is assessed by means of consistent comparisons to independent calculations and an estimate of the size of missing higher-order corrections. The main theoretical framework is overviewed and the status of the generator is summarized.
Microsystèmes communicants : modélisation, fabrication et mesures
Authors: Hage-Ali S. , Oudich M. , Claudel J. , Strèque J. , Tisserand E. , Mainka J. , Rouxel D. , Floer C. , Elmazria O. , Hehn M. , Weinachter F. , Weber S.
Published: October 2019

Nous présentons la mise en place de travaux pratiques et projets pédagogiques portant sur l’initiation à la modélisation, la fabrication et le test de microsystèmes communicants. Cette formation s’adresse aux étudiants de la licence 3 SPI et du Master EEA, parcours Capteur Intelligents Micro et nanotechnologie (CIM) à l’Université de Lorraine. Les travaux pratiques s’appuient d’une part sur de la modélisation par la méthode des éléments finis (FEM), et sur fabrication et la caractérisation des micro-dispositifs, notamment grâce à des ressources de l’Institut Jean Lamour à Nancy. L’exemple d’une étude de cas autour d’un capteur sans fil intégrant ces ressources est détaillé.
Régulation de débit d'un fluide dans un Laboratoire sur Puce
Authors: Schwartz François , Dumas Norbert , Rezgui Abir , Hébrard Luc
Published: October 2019

La formation Master à spécialité micro-nano électronique (MNE) de l'Université de Strasbourg propose, depuis l'année 2015, un enseignement intitulé « Projet de conception » présenté sous la forme d'un module de 4 heures de cours et de 24 heures de travaux pratiques. Les étudiants en seconde année de Master abordent le développement d'applications micro-fluidiques et plus précisément celui de l'électronique de pilotage d'actionneurs et de capteurs associés à un micro-laboratoire gravé sur une puce. Les généralités sur les régimes d'écoulement des fluides et le modèle du circuit fluidique y sont d'abord traitées. Une étude plus poussée conduit ensuite l'étudiant à dimensionner le circuit qui pilote une micro-pompe avec des niveaux de tensions spécifiques à la technologie High-Voltage 0,18 μm. Les notions d'automatique et de systèmes régulés sont indispensables en donnant un lien entre les objectifs et les performances attendues. Enfin, une série de simulations sous Cadence permet de relier les débits d'écoulement des fluides à la microélectronique de commande.
Transformation of the water system of the Education City in Doha into a smart water system
Authors: AL-NAEMI Abdallah , SHAHROUR Isam
Published: October 2019

This paper presents the transformation of the water system of the Education City in Doha (Qatar) into a smart water system. This city covers an area of 14 km2 and includes 80 buildings. The water system provides drinking, irrigation and fire protection services. It suffers from the use of fragmented management systems and from a lack of real-time monitoring, which result in a deterioration of efficiency of the water system and users’ information The paper describes the water system and then the architecture of the smart water solution and its use for leak detection, water quality control and operation safety.
Study on Risk Classification of Goaf Based on RS-SVM
Authors: Yuan Haiping , Le Biaohua , Wang Yubo , Chen Chenghao , Bian Hanbing
Published: October 2019

According to the uncertainty and concealment of the risk of goaf, a risk classification model of goaf is constructed based on rough set (RS) knowledge and support vector machine (SVM) theory. In this paper, based on statistical analysis and measured data, nine parameters including mining method, empty area excavation depth, goaf height, maximum exposed area of empty area, maximum exposure height, maximum exposure span, pillar condition, empty volume and treatment rate are selected as the main influencing factors. The RS theory is used to reduce the sample, and SVM is compiled by Matlab. The one-to-one method is used to construct the binary classifier to realize the multi-class classification algorithm of goaf. Finally, a SVM model for evaluating the risk level of the goaf is obtained. The research shows that: based on RS theory, SVM has a good effect on the hazard classification of the goaf iron ore mine, and the difference with the actual situation is 13.3%. The research results have certain theoretical significance and guiding role for the safe mining of an iron mine in Eastern China.
Analysis and interpret road traffic congestion costs in Lebanon
Authors: Saroufim Alain , Otayek Elie
Published: October 2019

The cost of environmental degradation in Lebanon was estimated to be close to $485 million per year, or 2.9 percent of the Gross Domestic Product (GDP). The large negative impacts of this degradation are the pollution occurring in urban area and is mainly caused by air pollution and with an average estimate of $145 million per year and around 0.87 percent of the GDP. This high air pollution is mostly linked to the transportation sector in Lebanon. Lebanon suffers from a daily increase in road network usage, which has resulted in gridlocks, especially in the greater Beirut area. By all means, the continued lack of policies and a political will to encourage the adoption of an efficient and reliable public transportation and to discourage the ownership of private vehicles have resulted in traffic growth that is faster than the road capacity. By all means, congestion is not a passing problem; it will continue to grow in the absence of measures to reduce traffic by adopting other modes of transportation, such as buses, trains, Trams, bicycles and others etc. This study describes the various factors that affect the costs associated with congestion, and provides well-defined methods for evaluating the corresponding costs.
Use of BIM and Smart Monitoring for buildings’ Indoor Comfort Control
Authors: Wehbe Rania , Shahrour Isam
Published: October 2019

Building information modeling (BIM) is the geometric way to present a life cycle construction project including geographic information. Recently, the Internet of Things (IoT) has been progressively used smart buildings in order to enhance living comfort, work productivity and entertainment. However, studies addressing the combination of these two technologies (BIM and IoT) focused on the automatic diffusion of data through sensors to BIM models [1]. Based on American College of Occupational and Environmental Medicine (ACOEM) a great portion of our time is spend inside buildings, in our offices, homes, schools, health care facilities, or in other private or public buildings. Hence the necessity to improve the basic human right to live in a healthy, safe and comfort environment is vital. This paper presents the use of BIM to support complex decisions concerning comfort conditions in buildings. This use is illustrated through a case study concerning a building of the AUST campus in Beirut.
Investigation of rock bolting for tunnels based on an efficient CATIA-ABAQUS model
Authors: Lee Hui , Chen Wei-zhong , Tan Xian-jun , Yang Qiao-chu , Wang Xiao-gang
Published: October 2019

As a widely used reinforcement method in tunnel engineering, the accuracy of models in numerical analysis has a vital influence on the reliability of the analysis results. To solve the problem of hard modeling for complicated models, this paper proposes to build models of different characteristics automatically by the means of Enterprise Knowledge Language (EKL) of CATIA, combining knowledge engineering template with parameterization. Furthermore, the stability of surrounding rocks and the distribution features of plastic areas were studied in different cases by CATIA-ABAQUS model. Besides, the effects and contributions of several parameters, including the rock-bolt diameter and interval between rock-bolts have been studied. It was found that: (1) Rock-bolt has a notable effect on the stability of the surrounding rocks. Increasing the diameter of rock-bolts contributes to significantly reduce the plastic area and the vertical displacement. With the increase of the quantity and the diameter of anchors, the degree of influence gradually weakens, showing the logarithmic relationship; (2) When the quantity and diameter of rock-bolts are constant, in the case in which the intervals between rock-bolts are various, the plastic area of surrounding rocks and the axial stress of rock-bolts are larger than that of the same distance, while the vertical displacement are uniform. (3) The excavation process has a great influence on the axial stress of rock-bolts and the redistribution of stresses in the surrounding rock.
Effect of age on the sex difference in Ironman triathlon performance
Authors: Piacentini Maria Francesca , Vleck Veronica , Lepers Romuald
Published: October 2019

The aim of this study was to investigate the effect of age on the sex differences in (3.8 km) swim, (180 km) cycle, (42 km) run, and overall performance time at the 2018 Ironman triathlon World Championship. Sex differences in performance times were analysed for the top 10 male and female amateur triathletes of each 5 years age group between 18–24 years and 70–74 years. Independent of age, the averaged sex difference in swimming, cycling, running, and overall performance time was 14.0 ± 3.3%, 15.6 ± 3.1%, 15.3 ± 6.8% and 15.1 ± 3.6%, respectively. There was no significant change with age in the sex difference in performance for swimming. For both cycling and running, the sex difference in performance of the age groups whose athletes were older than 60 years were significantly greater than those of younger age groups. Such results suggest that, in Ironman triathletes, the increase in the sex difference in performance with advancing age is discipline dependent. Further examination of the (physiological and training load related) factors that are associated with the age-related decline in Ironman triathlon performance is required to understand why the sex difference in cycling and running performance increases with age.
Hundebesitzer überwiegend zufrieden mit Radiotherapie ihrer Hunde
Authors: Schürg Andrea
Published: October 2019

Serras AR, Berlato D, Murphy S. Owners‘ perception of their dogs‘ quality of life during and after radiotherapy for cancer. J Small Anim Pract 2019; 60: 268–273.

Krebserkrankungen zählen auch bei Hunden zu den häufigsten Todesursachen: 25 % aller Hunde über 2 Jahre und 45 % aller Hunde über 10 Jahre sterben an Krebs. Viele Hundebesitzer werden also im Laufe ihres Lebens vor die Frage gestellt: Unterziehe ich mein Tier einer Strahlentherapie oder nicht? Überwiegen die Vorteile die möglichen Nebenwirkungen und wie beeinflusst die Therapie die Lebensqualität meines Hundes?
Zwei Hirne wissen mehr als eines – Peer Learning in der Praxis
Authors: Stickling Birgit
Published: October 2019

Wer bei einem Patienten nicht weiterkommt, ist gut beraten, sich zuerst einmal mit einem Kollegen auszutauschen. Eine Praxis in Freiburg setzt dieses kollegiale Feedback im sogenannten Peer Learning systematisch um. Einmal pro Woche finden sich während der Arbeitszeit feste Zweierteams zusammen und besprechen knifflige Fälle. Ein Mehrwert für Praxisinhaber, Angestellte und Patienten.
Fall für Vier – Abgeflacht
Authors: Hase Charlotte , Kanzler-Soiné Sabine , Seifert-Maciejczyk Mona , Müller-Prozyk Renate
Published: October 2019

Anna Müller leidet seit ihrer Kindheit an Knick-Senkfüßen. 2018 kommt für den linken Fuß nur noch eine OP in Frage. Ein Jahr später empfehlen ihr die Ärzte, auch den rechten Fuß operieren zu lassen. Doch die Patientin zögert wegen ihrer vielen Nebenerkrankungen. Sie entscheidet sich für den konservativen Weg und arbeitet mit einer Physiotherapeutin, einer Orthopädietechnikerin und einer Tanzpädagogin.
Wegweisende Ampeln – Algorithmen für Hüftgelenkluxationen und Skoliosen bei Zerebralparese
Authors: Salzmann Maya , Ackermann Wencke
Published: October 2019

Neben zahlreichen anderen Komorbiditäten haben fast alle Kinder und Jugendlichen mit Zerebralparese orthopädische Probleme – allen voran Hüftgelenkluxationen und Skoliosen. Zu deren frühzeitiger Erkennung und Therapie existieren hilfreiche Behandlungsalgorithmen. Die Hüftampel und die Wirbelsäulenampel sollten Therapeuten kennen und nutzen.
Übung des Monats – Der Lunge
Authors: Volker Hacker , Bauer Natascha , Keller Matthias
Published: October 2019

Die Kniebeuge gehört in ihren unterschiedlichen Variationen zu den Basisübungen in der Reha und dem funktionellen Training. Eine Variation ist der Lunge (dt.: Ausfallschritt). Sie eignet sich besonders gut zur Vorbereitung auf alternierende Bewegungsmuster wie das Joggen.
Erfolgreiche Behandlung eines mukokutanen Pemphigoids bei einem jungen Hund
Authors: Udraite Vovk Laura , Klinger Christoph J. , Böhm Teresa M. S. A. , Gedon Natalie K. Y. , Bettenay Sonya V. , Mueller Ralf. S.
Published: October 2019

Bei einem 2,5-jährigen, männlich-intakten Foxhound-Beagle-Mischling mit akuter, multifokaler, langsam fortschreitender, erosiv-ulzerierender Dermatitis ohne Juckreiz wurde basierend auf klinischen Symptomen und histologischer Untersuchung von Hautbioptaten ein mukokutanes Pemphigoid diagnostiziert. Betroffen waren Nasenspiegel, Augenlider und Schnauze. Bläschen fanden sich auch an Ohreninnenseiten, Maulschleimhaut und Zunge. Der Patient sprach nicht auf eine immunsuppressive Therapie mit Prednisolon an. Mit oraler Gabe von Doxycyclin und Niacinamid ließ sich eine vollständige Remission erreichen und die Erkrankung blieb unter langfristiger ausschließlicher Therapie mit Niacinamid in Remission.
Yuanhuatine from Daphne genkwa selectively induces mitochondrial apoptosis in estrogen receptor α-positive breast cancer cells in vitro
Authors: Zhang Ying-Ying , Shang Xin-Yue , Hou Xue-Wen , Li Ling-Zhi , Wang Wei , Hayashi Toshihiko , Zhang Yan , Yao Guo-Dong , Song Shao-Jiang
Published: October 2019

Breast cancer is one of the most common cancers diagnosed among women worldwide. Estrogen receptor alpha (ERα) is a transcriptional factor that plays an important role in the development and progression of breast cancer. Yuanhuatine, a natural daphnane-type diterpenoid extracted from Daphne genkwa, was reported to exhibit significant cytotoxicity against breast cancer cells. However, the underlying mechanism is still unclear. In this study, we evaluated the cytotoxicity of yuanhuatine on two breast cancer cell lines that are ERα-positive and -negative. The results show that yuanhuatine inhibits the growth of ERα-positive cells (MCF-7) with much stronger inhibitory activity (IC50 = 0.62 µM) compared with positive control tamoxifen (IC50 = 14.43 µM). However, no obvious cytotoxicity was observed in ERα-negative cells (MDA-MB-231). Subsequent experiment also indicated that yuanhuatine markedly induced mitochondrial dysfunction, leading to apoptosis in MCF-7 cells. Molecular docking studies suggest the potential interactions between yuanhuatine and ERα. Immunofluorescence staining and Western blot analysis indicated that yuanhuatine down-regulated the expression of ERα in MCF-7 cells. MPP, a specific ERα inhibitor, significantly enhanced yuanhuatine-induced mitochondrial dysfunction and apoptosis in MCF-7 cells. On the contrary, the treatment with yuanhuatine causes no apoptosis in MM231 cells. Altogether, in vitro and in silico results suggested that ERα down-regulation was involved in yuanhuatine-induced mitochondrial dysfunction and apoptosis in ERα-positive breast cancer cells. Thus, yuanhuatine could be a potential candidate for treating ERα-positive breast cancer.
Just Expect It: Compound Heterozygous Variants of POMT1 in a Consanguineous Family—The Role of Next Generation Sequencing in Neuromuscular Disorders
Authors: von der Hagen Maja , Becker Lena-Luise , Wienker Thomas F. , Smitka Martin , Musante Luciana , Ropers Hans-Hilger , Huebner Angela , Hu Hao , Kaindl Angela M.
Published: October 2019

Muscular dystrophy-dystroglycanopathies (MDDG) are a group of genetically heterogeneous autosomal recessive disorders characterized by hypoglycosylation of α-dystroglycan. Here, we report on two female patients from a consanguineous Lebanese family that presented in early infancy with generalized muscle hypotonia and primary microcephaly. Brain magnetic resonance imaging (MRI) showed different degrees of hypoplasia of the cerebellar vermis and hypoplasia of corpus callosum. Muscle biopsy analyses revealed a muscular dystrophy with reduced expression of α-dystroglycan and merosin in immunoblot analyses. Homozygosity mapping failed to elucidate the causal mutation due to the accepted notion that, in consanguineous families, homozygote mutations cause disease. However, by applying whole exome sequencing, we identified a novel compound heterozygous POMT1 mutation that segregates with the phenotype and is in line with the clinical presentation. This underscores that a less expected compound heterozygous instead of homozygous mutation in a consanguineous marriage results in a recessive disorder and highlights the growing role of next generation sequencing in neuromuscular disorder diagnostics.
Bacteriophage Therapy: An Alternative to Antibiotics—An Experimental Study in Mice
Authors: Nath Gopal , Janam Ram , Kumar Rajesh , Gangwar Mayank
Published: October 2019

The present study was planned to evaluate the efficacy of Pseudomonas aeruginosa specific phages in immunocompromised septicemia animal model as an alternative to antibiotics. Five different sets of experiments were performed: prophylactic administration of phage cocktail (3 lytic and unique) before and simultaneous with bacterial challenge; and therapeutic, that is, administration of phage cocktail 6, 12, and 24 hours after the bacterial challenge. No mortality was observed when simultaneous and late administration of phages was done with respect to the bacterial challenge. Contrary to this, administration of phage cocktail 100 µL (1012 PFU/mL) of volume after 6 hours of the infection resulted in a mortality rate of 60%. However, no mortality could be observed with reduced dose of cocktail, that is, 108, 109, and 1010 PFU administered 6 hours after bacterial challenge. Phage therapy in acute infections initiated with very small dosage under strict supervision may give better results. However, further studies to determine the quantity and frequency of dosage of phage cocktail for septicemia of various durations is strongly indicated.
Efficacy and Safety of Defibrotide for the Treatment of Hepatic Veno-Occlusive Disease after Hematopoietic Stem Cell Transplantation: A Systematic Review and Meta-Analysis
Authors: Yang Liping , Qi Jiaqian , Pan Tingting , You Tao , Ruan Changgeng , Han Yue
Published: October 2019

Defibrotide has been approved in several geographic jurisdictions for the treatment of hepatic veno-occlusive disease/sinusoidal obstruction syndrome (VOD/SOS) for years. However, available data on efficacy and safety for its use in VOD are contrasting. We performed a meta-analysis to evaluate the efficacy and safety of defibrotide in the treatment of hepatic VOD/SOS post-hematopoietic stem cell transplantation (HSCT). PubMed and Embase were searched for studies regarding the efficacy and safety of defibrotide in VOD patients. Survival rate at day + 100 post-HSCT (D + 100 SR), as well as the prognosis, comprising complete response (CR), adverse events including ≥1 adverse event (≥1 AE), hemorrhage, and serious adverse events (SAEs), were pooled using a random effect model. Sixteen studies involving 3,002 participants were included. Pooled estimates for overall D + 100 SR as well as rate of CR, ≥1 AE, hemorrhage, SAEs in VOD patients post-HSCT were 58% (95% CI: 54–62%), 57% (95% CI: 45–68%), 65% (95% CI: 54–75%), 16% (95% CI: 5–27%), 53% (95% CI: 51–55%), respectively, and were 44% (95% CI: 39–48%), 39% (95% CI: 28–50%), 88% (95% CI: 71–100%), 42% (95% CI: 30–55%), 58% (95% CI: 52–64%), respectively, in severe VOD (sVOD) patients. Hemorrhage and hypotension were the most common AEs. Current evidence suggests that defibrotide improves the D + 100 SR and CR in VOD/sVOD patients following HSCT. However, the results of this review/meta-analysis were mainly based on data from observational studies, potentially subject to selection bias. Consequently, higher quality randomized control trials and larger prospective cohort studies are warranted.
Treatment with Antithrombin or Thrombomodulin and Mortality from Heatstroke-Induced Disseminated Intravascular Coagulation: A Nationwide Observational Study
Authors: Ohbe Hiroyuki , Isogai Shunsuke , Jo Taisuke , Matsui Hiroki , Fushimi Kiyohide , Yasunaga Hideo
Published: October 2019

Heatstroke-induced disseminated intravascular coagulation represents potential targets for specific intensive treatments. However, the effect of antithrombin or thrombomodulin treatment remains uncertain. Using a large nationwide inpatient database in Japan, this study aimed to evaluate whether treatment with antithrombin or thrombomodulin could reduce mortality among patients with heatstroke-induced disseminated intravascular coagulation. Using the Japanese Diagnosis Procedure Combination inpatient database from April 2014 to March 2017, we identified heatstroke patients who developed disseminated intravascular coagulation. We allocated patients who started treatment with antithrombin or thrombomodulin within 2 days after admission to the treatment group and allocated others to the control group. A primary outcome was in-hospital mortality. We used a doubly robust analysis to ensure the robustness of our findings. We also conducted two sensitivity analyses for thrombomodulin versus others and antithrombin versus others. We identified 1,606 eligible patients during the 81-month study period. Of these, 556 (35%) received antithrombin or thrombomodulin. The doubly robust analysis demonstrated that in-hospital mortality was significantly lower among patients in the treatment group than among those in the control group (risk difference −6.5%; 95% confidence interval: −12 to −1.4%). In-hospital mortality was significantly lower in patients with thrombomodulin than in others (risk difference −5.5%; 95% confidence interval: −9.5 to −1.6%). There was no significant difference in in-hospital mortality between patients with antithrombin and others (risk difference −4.2%; 95% confidence interval: −9.3 to 0.9%). Treatment with recombinant human thrombomodulin may be associated with lower in-hospital mortality among patients with heatstroke-induced disseminated intravascular coagulation.
Self-assembly of active core corona particles into highly ordered and self-healing structures
Authors: Du Yunfei , Jiang Huijun , Hou Zhonghuai
Published: October 2019

Formation of highly ordered structures usually needs to overcome a high free-energy barrier that is greatly beyond the ability of thermodynamic fluctuation such that the system would be easily trapped into a state with many defects and the annealing process of which often occurs on unreachable long time scales. Here, we report theoretically a fascinating example that active core corona particles can successfully self-assemble into a large-scaled and highly ordered stripe or trimer lattice, which is hardly achieved in a nondriven equilibrium system. Besides, such an activity-induced ordered structure shows an interesting self-healing feature of defects. In addition, there exists an optimal level of activity that most favorably enhances the formation of ordered self-assembly structures. Since core corona particles act as important units for self-assembly in real practice, we believe that our study opens a new design-strategy for highly ordered materials.