bluuebunny/crossref_metadata_2025 huggingface dataset:
About Bellman Principle and Solution Properties for Navier–Stokes Equations in the 3D Cauchy Problem
Authors: I. Semenov Vladimir
Published: July 2024

Without belittling the achievements of many mathematicians in the studying of the Navier-Stokes equations, the real ways opened J. Leray and O.A. Ladyzhenskaya. The main goal of this work is to compare the smoothness property of a weak solution in the Cauchy problem after some moment if it is known solution regularity until this moment with the optimality property in the Bellman principle. Naturally, all these are connected with the existence problem of blow up solution in the Cauchy problem for Navier-Stokes equations in space attracting a lot of attention up to now. The smoothness control and controlling parameters can be varied. It is important to control the dissipation of kinetic energy to the fix moment or rate of change of kinetic energy square or the summability of velocity gradient to the fixed point in time and so on. There are possible other control parameters due to a weak solution.
Two Modeling Approaches for sCO2-PCHEs Transients
Authors: Sui Xin , Dong Peixin
Published: July 2024

Printed circuit heat exchangers (PCHEs) are ideal for sCO2 power cycles due to their compactness, effectiveness, and high-pressure capability. However, their unique architecture complicates the modeling of their dynamic behavior in power cycles, which experience rapid transients. Both the significant computational resources required and the high investment costs of experiments limit their widespread application. To model the component- and system-level transients of sCO2-PCHEs, this study presents two 1D modeling approaches for different purposes: one for component-level simulation based on local properties of sCO2, and the other for system-level simulation based on transfer functions. Given the significant discrepancies observed when using a fixed time constant in the latter approach, this paper introduces the concept of an optimal time constant to model the transient behavior of PCHEs as a first-order system with minimal prediction error. This optimal time constant varies with operating conditions, contrary to what the name might suggest. These results demonstrate the potential of PCHEs in advanced power cycles and provide valuable insights for accurate system-level sCO2 power cycle control studies.
Ant Colony Optimization-Based Models for Agriculture Price Forecasting: Innovations, Case Studies, and Future Prospects
Authors: Choudhary Kapil
Published: July 2024

Agricultural price forecasting is a critical component of modern farming, enabling stakeholders to make informed decisions. In recent years, computational intelligence techniques, such as ant colony optimization (ACO), have emerged as promising tools for enhancing the accuracy and robustness of price forecasting models. This chapter explores the innovative use of ACO-based models in agriculture price forecasting, backed by insightful case studies that demonstrate their practical applicability. The synergy between ACO and agriculture price forecasting is examined, with a focus on the unique challenges and opportunities presented by this domain. By dissecting the intricacies of these applications, we gain valuable insights into the practical implementation of ACO for agriculture price forecasting. Looking ahead, we discuss the future prospects of ACO in this field. We identify emerging trends, potential areas for improvement, and avenues for further research. The chapter concludes with a call to action for researchers, practitioners, and policymakers to collaborate in harnessing the full potential of ACO-based models, ultimately advancing the reliability and effectiveness of agriculture price forecasting. In summary, this chapter serves as a comprehensive exploration of the intersection between ant colony optimization and agriculture price forecasting. It bridges the gap between theoretical concepts and real-world applications, providing a roadmap for future advancements in this crucial domain.
Effect of Pig Domestication on Skeletal Muscle Development, Microstructure, and Genetic Mechanism Involved in Myofibre Type Formation
Authors: Vrecl Milka , Brankovič Jana , Fazarinc Gregor
Published: July 2024

The wild boar and modern highly selected pigs are phenotypically distant European pig breeds reared in contrasting conditions and present ideal model to better understand the mechanisms behind meat quality deterioration related to domestication and selection pressure, which provoked substantial modifications in the ontogenic development as well as contractile and metabolic properties of skeletal muscles. The skeletal muscle of domestic pigs are less mature at birth and contains a lower number of myofibres compared to wild boars; however, expansive myofibre hypertrophy, protein accretion as well as additional myofibre formation are accelerated in the early postnatal period in some muscles in domestic pigs. A comparative view of the cellular and subcellular mechanisms underlying the skeletal myofibre development could help to design a breeding program that would improve the balance between the growth performance, muscularity and meat quality. This chapter therefore outlines the influence of domestication on myofibre formation and differentiation during growth and provides a comparative view on the developmental expression pattern of the MyHC isoforms, the activity of different metabolic enzymes, and the expression of selected genes responsible for the metabolic diversity of the myofibres. Additionally, there is a special emphasis on the type, composition, and histomorphological traits of myofibres.
BELL DIFFERENCE SEQUENCE SPACES
Authors: Jena Diptimayee , Dutta Salila
Published: July 2024

In this article we define the new sequence spaces Bˆ ∞ (∆), Bˆ c (∆) and Bˆ 0 (∆) by introducing a new regular matrix Bˆ ∆ with the composition of the Bell matrix Bˆ and the backward difference operator ∆. Also we have determined the Schauder basis, certain inclusion relations, α−, β− and γ−duals along with matrix transformations.
GRAPHICAL VERSION OF BROUWER’S FIXED POINT THEOREMS OVER METRIC SPACE
Authors: Dewangan Kiran
Published: July 2024

The aim of this paper is to present graphical version of Brouwer’s fixed point theorem and to establish some useful results of partial order set and nonexpansive mapping defined on a partial order set. One application of the fixed point theory by combining graph theory is discussed here by using Dijkstra’s algorithms which is useful in computer science.
ANALYSIS OF MULTIFACTOR IMPRECISE DATA USING NEUTROSOPHIC STATISTICS
Authors: Kumar Pranesh
Published: July 2024

In multifactor experiments, data collected may correspond to the categorical variables, which place individuals/items into one of several groups (categories). The values of a categorical variable are levels for the categories and distribution of a categorical variable lists the count or percent of individuals/items falling into each category. For example, a two-way table describes two categorical variables by arranging counts according to a row variable and a column variable and each combination of values for two variables is called a cell. However, sometimes a few or every cell counts may be imprecise numbers because of missing or incomplete information on the sample individuals, or investigators negligence, or any other reasons. In such situations, data need to be analyzed using neutrosophic logic and neutrosophic statistics. Generally, the objective of contingency table analysis is to study goodness of model fit for discrete or continuous distributions, testing for homogeneity, and testing for independence. In this paper, we consider neutrosophic analysis of categorical data, which is arranged in contingency tables. We discuss results obtained from the neutrosophic contingency table analysis using data observed in various applications.
Evaluating the pharmacokinetic parameters of a single dose of oral disintegrating tablets in elderly patients with hypertension and hyperlipidemia
Authors: Khalid Khushbu , Faiz Sidra , Irfan Hira
Published: July 2024

Cardiovascular diseases (CVDs) are the leading cause of death worldwide, particularly in underprivileged areas such as Pakistan. Hypertension and hyperlipidemia are major risk factors for CVDs and often require medication for effective management. This study aimed to develop and validate a high-performance liquid chromatography (HPLC) method to assess the bioavailability of orally disintegrating tablets (ODTs) of atenolol and atorvastatin in elderly volunteers with high blood pressure and cholesterol levels by comparing the pharmacokinetic parameters of these ODTs with those of conventional tablet formulations. The study was conducted in Sargodha, Punjab Province, Pakistan, by recruiting 30 male and female elderly volunteers aged 45-65 years and weighing 60-90 kilograms. Each participant was administered a single dose of atenolol (25 mg), atorvastatin (10 mg), or an ODT containing both drugs. Blood samples were collected at specific intervals up to 48 hours postadministration. The concentrations of atenolol, atorvastatin, and the ODTs were measured using HPLC, and various pharmacokinetic parameters, including the area under the curve (AUC), maximum plasma concentration (Cmax), and elimination half-life (t½), were analyzed. The maximum concentration (Cmax) of 10 mg atorvastatin occurred at 4 hours (9.50 ng/mL), while for 25 mg atenolol, it peaked at 4 hours (150.00 ng/mL). The ODTs showed comparable pharmacokinetic profiles, with the Cmax values for atorvastatin and atenolol at 4 hours being 4.00 ng/mL and 165.00 ng/mL, respectively. The elimination half-life (t½) for the ODTs was 4.62 hours for atorvastatin and 4.95 hours for atenolol. The pharmacokinetic analysis indicated that the AUC and Cmax of the ODTs met the bioequivalence criteria, demonstrating absorption and elimination properties similar to those of conventional tablet formulations. The study concluded that the pharmacokinetic parameters of the ODT formulations atenolol and atorvastatin are comparable to those of conventional tablets. ODTs offer a viable and effective alternative for delivering these medications, particularly for patients who have difficulty swallowing pills, thereby potentially improving patient compliance.
ADVENTIVE TREE AND SHRUB PLANT SPECIES WITH MEDICINAL PROPERTIES IN THE CHERNIHIV CITY’S GREEN INFRASTRUCTURE
Authors: Lukash Oleksandr , Stupak Yuliia , Morskyi Vitalii , Aravin Maksym
Published: July 2024

Purpose of the work was to identify introduced species of woody and shrubby plants with medicinal properties in the Chernihiv city’s green infrastructure and to characterize the medicinal properties of these plants, as well as to determine their role in providing ecosystem services and to assess the potential possibilities of harvesting them as medicinal raw materials.
Methodology. The materials were collected during research of green infrastructure facilities of the Chernihiv city in 2022–2023 using geobotanical methods (Yakubenko et al., 2018). During field research, the degree of invasive activity of introduced trees and shrubs species was recorded. Degrees of invasiveness were measured according to Wagh and Jain (2018) with authors modificationand categorised into 4 different categories namely, recently introduced, possibly invasive, moderately invasive and highly invasive on the basis of their availability. Each category has been given a number (1 to 4) on the basis of the impact of the species in the study area, the higher the number the higher the invasive impact: recently introduced (1), possible invasive (2), moderately invasive (3) and highly invasive (4). In order to characterize the medicinal properties of plants, information sources of the last 20 years were analyzed.
Scientific novelty. The composition of introduced medicinal trees and shrubs of the green infrastructure of the Chernihiv city was determined. Their role in the optimization of the network of natural, semi-natural and man-made areas of the green infrastructure of Chernihiv has been established. Medicinal plants are recommended for harvesting and use.
Conclusions. One of the most compelling motivations to integrate adventive trees and shrubs with medicinal properties into the landscape the green infrastructure of the Chernihiv city is the ecosystem services they provide.
Another advantage of using introduced trees and shrubs in the Chernihiv city’s green infrastructure landscapes of is economic. It is that most introduced trees and shrubs are resistant to pests and drought, so less water and fertilizers are needed to grow them.
Adventive tree and shrub medicinal plants play a primary role in the restoration of man-made and semi-natural damaged areas, which are necessary to create a complete network of the urban green infrastructure.
The spectrum of pharmacological properties of adventive trees and shrubs that grow in the Chernihiv city’s green infrastructure is quite diverse: from medicinal and cosmetological to antidiabetic and anticancer effects. However, the harvesting of a number of plants is limited by resources and the ecologically unfavorable environment of their habitats. Moderately invasive and highly invasive plants have significant resources and grow in an ecologically safe environment. The procurement of medicinal raw materials from these plants is to regulate their distribution in the natural objects of the Chernihiv city’s green infrastructure.
ANALISIS KESTABILAN LERENG MENGGUNAKAN METODE ROCK MASS RATING, SLOPE MASS RATING, DAN JANBU PADA JALAN SUMBING, KELURAHAN BENDUNGAN, KECAMATAN GAJAHMUNGKUR, KOTA SEMARANG
Authors: Herfaes Bey Anandha , Giraldi Devina Aldalivia Budhi , Yasmin Lutfia , Widiarso Dian Agus
Published: July 2024

Kestabilan lereng merupakan suatu kondisi atau keadaan yang mantap atau stabil terhadap suatu bentuk dan dimensi lereng. Gerakan tanah yang terjadi di Indonesia setiap tahunnya mengalami peningkatan terutama pada musim hujan. Pergerakan massa tanah merupakan suatu proses geologi yang dimana merupakan hasil interaksi kondisi yang terjadi pada suatu lingkungan seperti morfologi, geologi, struktur geologi, hidrogeologi, dan penggunaan lahan. Selain itu, terdapat juga pengaruh dari kondisi tektonik yang ada diIndonesia, yang dimana kondisi tektonik ini menyebabkan terbentuknya kenampakan morfologi berupa tinggian, patahan, batuan yang mudah lapuk yang dikarenakan adanya pengaruh iklim tropis, sehingga menyebabkan potensi gerakan tanah semakin tinggi. Selain itu, adanya faktor pertumbuhan penduduk yangsangat pesat, dapat memberikan dampak juga pada perubahaan tata guna lahan, sehingga mengakibatkanbencana gerakan tanah akan semakin meningkat. Keruntuhan pada lereng alami atau buatan disebabkan karena adanya perubahan antara lain topografi, seismik, aliran air tanah, kehilangan kekuatan, perubahan tegangan, dan musim / iklim / cuaca. Akibat adanya gaya-gaya luar yang bekerja pada material pembentuk lerengmenyebbakan material pembentuk lereng mempunyai kecenderungan untuk menggelincir.
 
Kata kunci: Lereng; Tanah; Tektonik; GeologKOTASEMARANG
ANALISIS TINGKAT KELONGSORAN MENGGUNAKAN METODE ROCK MASS RATING (RMR) , SLOPE MASS RATING (SMR) SERTA METODE BISHOP PADA LERENG BATUAN X, KELURAHAN JANGLI, KECAMATAN TEMBALANG, KOTA SEMARANG
Authors: Nickolas Syafrichard Ihsan , Nurfaizi Nick , Husain Habib , Widiarso Dian Agus
Published: July 2024

Kawasan penelitian berlokasi di Kelurahan Jangli, Kecamatan Tembalang, Kota Semarang. Kawasan ini berada dekat dengan kawasan pemukiman sehingga faktor keamanan lereng menjadi faktor penting yang harus diperhatikan. Lereng batuan yang aman dari longsor tentunya harus memenuhi berbagai kriteria dan pembobotan tertentu sesuai dengan metode yang digunakan. Longsor merupakan pergerakan massa tanah atau batuan sepanjang bidang tergelincir atau suatu permukaan bidang geser. Terjadinya suatu peristiwa tanah longsor tentunya disebabkan oleh berbagai faktor-faktor alam seperti adanya peran dari struktur geologi, mekanika batuan, kuat tekan batuan, maupun faktor geologi lainnya. Adapun penelitian kali ini memiliki fokus utama terkait dengan analisis RMR dan SMR dan penggunaan metode Bishop dalam mengidentifikasi tingkat kelongsoran lereng batuan penelitian. Dari penelitian yang telah dilakukan, diketahui bahwasanya pada metode RMR didapati nilai pembobotan sebesar 72 yang, menurut klasifikasi Bieniawski (1989), termasuk dalam kelas II atau "Pemerian Baik". Sementara dalam analisis SMR, hasil perhitungan mengungkapkan persentase kinematika wedge sliding sebesar 0,62%. Pembobotan F1, F2, F3, dan F4 menghasilkan nilai SMR sebesar 86,1, yang secara klasifikasi dikategorikan sebagai "very good" atau "sangat baik". Hasil pengolahan data dengan menggunakan Metode Bishop juga menunjukkan nilai kondisi lereng yang aman, baik dalam kondisi kering maupun kondisi jenuh, di mana nilai yang diperoleh menunjukkan FK>1,25. Dengan demikian, bahwa kondisi massa batuan di lokasi tersebut sangat stabil, dengan potensi kegagalan atau longsoran yang rendah
OPTIMIZATION OF THE OPERATION OF AN ISOMERIZATION INSTALLATION FOR LIGHT PETROL FRACTIONS
Authors: N.U. Nurgaliyev N.U. , Amankeldin D.Zh. , Zhunussova E.B. , Omarov Kh.B. , Zhumabekova A.K. , Ussenkulova Sh.Zh. , Orynbassar O.R.
Published: July 2024

The interest in this process lies in the fact that it has great value since low-octane components are used as raw materials - the n fraction. temperature – 62°С and catalytic reforming raffinates. This raw material contains mainly pentane and hexane fractions. This raw material, as well as fractions С5 and С6 obtained from a gas fractionation unit (GFU), and a central gas fractionation unit (CGFU), are isomerized in a hydrogen environment in the presence of a catalyst. Hydrocarbons with a relatively high octane number are obtained. When isomerizing the pentane fraction, a product with a higher octane number is obtained. Isomerization of n-pentane is of interest not only for the oil refining industry, but also for the petrochemical industry, since isopentane can be converted by dehydrogenation into isoprene, a raw material for rubber. The article conducted a study on the selection of the optimal catalyst for the light gasoline fraction isomerization unit located at the Atyrau Oil Refinery. The catalytic activity of the catalyst samples was assessed in a laboratory flow-type installation. Determination of the mass fraction of С2-С5 hydrocarbons in С5 hydrocarbon fractions (in raw materials and catalyst) was carried out by a method based on the separation of mixture components by gas-liquid chromatography. The components leaving the chromatographic column were detected using a thermal conductivity detector. The calculation of the mass fractions of components was carried out using the normalization method, taking into account correction factors. The minimum concentration of C2-С5 hydrocarbons, determined by the method used, is 0.01-0.05% wt.
Hydroelectric Power Generation System in Tanggari (PLTA Tanggari 2)
Authors: S. Pongoh Deitje , Pongoh Johan. , Luther Mappadang Jusuf , Mandagi Samuel , Ante Teovano , Ardiani Dina , Sondakh Yehezkiel , Monopode Alfaro
Published: July 2024

The research objective of PLTA Tanggari 2 is to understand and analyze the hydropower system from energy generation to distribution to end consumers, both households and industries. This research aims to improve the efficiency and performance of the entire electricity generation and distribution system. The research methodology used in making this journal is to collect sources or information related to the topic of discussion, namely hydroelectric power plants. The study explores the utilization of hydropower in the Tondano watershed to address electricity needs in North Sulawesi. Tanggari 2 Hydropower Plant exemplifies this by harnessing the potential and kinetic energy of water through a dam on the Tondano River. With an extensive watershed area of 4,700 hectares and Lake Tondano at its core, this system is optimized to efficiently generate electricity for the entire region. The input-output dynamics of hydropower plants are crucial, detailing how water flow drives turbines, ultimately leading to electrical output. This research underscores the potential of watershed utilization as an accessible, economical, and sustainable energy source for broader regional electrification endeavors. The implications of this research extend to enhancing understanding and analysis of water-based power generation systems, from energy production to distribution to end consumers. By improving the efficiency and performance of these systems, there is a significant potential for sustainable energy solutions that can benefit both households and industries in the broader regional context of North Sulawesi.
A INFLUÊNCIA DAS DISCUSSÕES SOCIAIS NO COMPORTAMENTO DAS EMPRESAS: O CASO DO EMPODERAMENTO CRESPO/CACHEADO
Authors: Santana Mirele Araújo , Silva Adriana Carneiro da
Published: July 2024

As ressignificações sociais têm impactado de forma direta ou indiretamente nas decisões organizacionais, já que elas não funcionam de maneira isolada, o ambiente externo é um forte impulsionador de novos direcionamentos para as organizações. Assim, o objetivo deste trabalho foi compreender, a partir do empoderamento crespo/cacheado, como as discussões sociais têm influenciado o comportamento das empresas. O trabalho caracteriza-se em um estudo de caso da marca Salon Line que de maneira criativa vem se reposicionando no mercado e conquistando um novo público consumidor. Foi identificado que o empoderamento crespo/cacheado além de contribuir para o processo de afirmação da comunidade negra, também instituiu oportunidades de ascensão mercadológica para as empresas que atendem esse nicho, que até então não era percebido pelas marcas anteriormente.
AUDIODESCRIÇÃO E SISTEMA DE LEITURA TÁTIL: UMA PROPOSTA DE INCLUSÃO EM MUSEUS
Authors: Freitas Isadora Almeida São Paulo de , Freitas Tanara Almeida de , Almeida Rosângela Maria Barreto dos Santos de , Portugal Viviane Maria Simas Silva
Published: July 2024

Este trabalho tem como objetivo discutir abordagens que podem ser adotadas para criar experiências mais inclusivas. Uma implementação do uso de audiodescrição e de um sistema de leitura tátil em um museu de zoologia localizado na Universidade Estadual de Feira de Santana. É de extrema importância discutir como essas abordagens promovem o acesso à cultura e à arte para todos, direcionando-se especificamente para indivíduos com deficiência visual, público alvo desta pesquisa. Esses recursos foram aplicados ao diorama do bioma da Caatinga e aos exemplares em exposição, que podiam ser tocados. O objetivo geral de produção e análise foi alcançado com sucesso. Para compreender a natureza qualitativa, exploratória e descritiva da abordagem, esta pesquisa utilizou o procedimento de pesquisa-ação para a coleta de dados. Os dados foram analisados a partir de uma perspectiva discursiva. Os resultados mostraram que atualmente não há acessibilidade no museu e que a implementação dessas mudanças atenderia às necessidades básicas de pessoas com deficiência visual.
Principio de irretroactividad y el derecho a la seguridad jurídica dentro de los procesos de régimen semiabierto
Authors: Jennifer Liseth Gonzaga Moncayo  , Luis Andrés Chimborazo Castillo
Published: July 2024

Dentro de uno de los beneficios penitenciarios que contempla el ordenamiento jurídico ecuatoriano, se regula al régimen semiabierto, el cual es una modalidad a través de la cual las personas privadas de la libertad pueden continuar cumpliendo su pena desde afuera del centro de rehabilitación, esto gracias al cumplimiento de algunos requisitos, lo cual implica que al ser una figura legal debe estar aplicada en función de lo determinado por la normativa vigente; sin embargo, aun en la práctica existen procesos en donde no se toma en cuenta el principio de irretroactividad lo que provoca una vulneración conexa a la seguridad jurídica. Por lo que, dentro de esta investigación el objetivo general es analizar el principio de irretroactividad y el derecho a la seguridad jurídica dentro de los procesos de régimen semiabierto. Para el efecto, se empleó una metodología con enfoque cualitativo, bajo el empleo de un método dogmático y exegético de la investigación a fin de revisar la teoría y lo que determina la norma respecto del tema de investigación. Para llegar a concluir que, cuando los operadores de justicia no respetan el procedimiento legal vigente dentro de un régimen semiabierto, vulneran el principio de irretroactividad y seguridad jurídica.
Análisis de los recursos gastronómicos con potencial turístico en la zona de Puerto López. Parque Nacional Machalilla, Ecuador
Authors: Jonathan Luis Cruz Pierard  , Doris Jeanneth Jiménez Durán
Published: July 2024

El objetivo de la investigación se enfoca en analizar los recursos gastronómicos de Puerto López, ubicados en el Parque Nacional Machalilla de Ecuador y en examinar la influencia del consumo de platos tradicionales en el flujo de visitantes a los atractivos turísticos de la región. Se empleó un método cuantitativo y descriptivo, complementado con herramientas cualitativas como entrevistas y grupos focales. Estas últimas se dirigieron a expertos y exfuncionarios de entidades relacionadas con el turismo y la gastronomía. Los resultados obtenidos se analizaron considerando aspectos como la categorización de los establecimientos, la cantidad de plazas disponibles, la identificación de territorios gastronómicos y la oferta actual de platos típicos.
Evaluación del riesgo financiero y su impacto en la toma de decisiones en la empresa turística lago adventure en el año 2020-2021 a través de análisis financiero
Authors: Yuneisy Díaz Peña  , Diego Gustavo Toapanta Cunalata
Published: July 2024

El presente trabajo de investigación se enfoca en la evaluación del riesgo financiero y su impacto en la toma de decisiones en la empresa turística LAGO ADVENTURE durante el periodo 2020-2021, a través del análisis financiero. El objetivo principal es evaluar el impacto del análisis financiero en la toma de decisiones de la empresa, aplicando los métodos de análisis vertical y horizontal a los estados financieros, y analizando los resultados obtenidos. La investigación se fundamenta en las dificultades que enfrentan las empresas para tomar decisiones seguras debido a la limitada información financiera y la falta de un análisis financiero adecuado. Los resultados permitirán a los directivos de la empresa tomar decisiones informadas para mejorar su desempeño financiero.
El juego como precursor en el desarrollo de las intenciones comunicativas: Revisión de la literatura.
Authors: Sotomayor León Karen Narcisa , Merizalde Yperti Nereyda Dayanara , Jara Baquerizo Marcela Lisbeth , Macas Vera Erika Kassandra , Macas Vera Armyth Elizabet
Published: July 2024

El objetivo de esta revisión narrativa fue analizar el papel del juego como precursor en el desarrollo de las intenciones comunicativas en la infancia. Se realizaron búsquedas exhaustivas en SciELO y Google Académico para identificar estudios relevantes publicados entre 2018 y 2023. Se incluyeron investigaciones revisadas por pares que abordaran la relación entre el juego y el desarrollo del lenguaje en niños. Se excluyeron aquellos estudios que no proporcionaban datos empíricos o que se centraban en poblaciones adultas. Los métodos empleados incluyeron una lectura crítica y sistemática de los estudios seleccionados, evaluando la calidad metodológica, la relevancia de los hallazgos y la aplicabilidad de las conclusiones. Se extrajeron datos clave como el diseño del estudio, la muestra, las intervenciones utilizadas y los resultados obtenidos. La síntesis narrativa agrupó los estudios por temas comunes, destacando tendencias emergentes y lagunas en la literatura. Los resultados indican que el juego es una herramienta poderosa para el desarrollo del lenguaje y la comunicación en la infancia. Las actividades lúdicas facilitan la exploración y manipulación del lenguaje, promoviendo el desarrollo fonológico, léxico y gramatical. Además, el uso de tecnologías de la información y la comunicación (TIC) y juegos de mesa verbales se ha demostrado eficaz para estimular la expresión oral en niños con dificultades comunicativas.
CRISPR-Cas9 Mediated Gene Editing for Targeted Cancer Therapy: Mechanisms, Challenges, and Clinical Applications
Authors: Paul-Chima Ugwu Okechukwu ,   Department of Publication and Extension, Kampala International University Uganda, Nkemjika Anyanwu Chinyere , Ugo Alum Esther , Ben Okon Michael , Ikechukwu Egba Simeon , Ejim Uti Daniel , Adie Awafung Emmanuel ,   Department of Microbiology and Immunology Kampala International University Uganda,   Department of Publication and Extension, Kampala International University Uganda,   Department of Publication and Extension, Kampala International University Uganda,   Department of Publication and Extension, Kampala International University Uganda,   Department of Publication and Extension, Kampala International University Uganda,   Department of Biomedical Engineering Kampala International University Uganda
Published: July 2024

The CRISPR-Cas9 system has revolutionized gene editing with its high efficiency and specificity, offering new avenues for targeted cancer therapy. This review focuses on the mechanisms through which CRISPR-Cas9 can be used to suppress oncogenes, restore tumor suppressor genes, and enhance immunotherapy by editing key genetic sequences. This review also explores how CRISPR-Cas9 targets DNA repair pathways such as homology-directed repair (HDR) and non-homologous end joining (NHEJ), emphasizing the precision required for successful cancer treatment. Despite promising in vitro results and ongoing clinical trials, challenges such as off-target effects and immune responses remain. This review also highlights advances in CRISPR technology, preclinical and clinical studies, combination therapies, and future directions in cancer therapy. Keywords: CRISPR-Cas9, cancer therapy, gene editing, DNA repair pathways, oncogenes, tumor suppressor genes, immunotherapy, clinical trials
Integrating Religious Moderation into Islamic Religious Education: Strategies and Impacts
Authors: Ratnah  , Ali Shah Syed Ahmad , Alam Mumtaz
Published: July 2024

This study examines the implementation of religious moderation values in Islamic religious education at SMK TI Bali Global Klungkung. Through a qualitative approach, the main finding of this research is the identification of ten religious moderation values being implemented: justice, balance, tolerance, centrism, love for the country, deliberation, improvement, pioneering, non-violence, and cultural friendliness. The implementation is achieved by integrating these values into the curriculum, evaluation techniques, and daily life practices, as well as through habituation and exemplification. The results have positive implications, such as establishing harmonious relationships between Muslim students and the community, increasing student achievement and creativity, and boosting the number of Muslim students in the school. The findings align with the concept of moderation in Islam, behavioristic theory, and expert opinions on religious moderation as a solution to the problem of radicalism. This research contributes to forming students with moderate, tolerant, fair, balanced, and non-violent characters who can adapt to a pluralistic environment following the objectives of Islamic education. The limitation of this study is that its scope is confined to one school.
The Degree of Capillary Absorption Reduction as a Parameter to Classify the Effectiveness of Secondary Horizontal Waterproofing
Authors: Monczyński Bartłomiej
Published: July 2024

The dampness of the ground floors in buildings is generally a consequence of capillary rise of groundwater caused by the absence, damage or technical deterioration of the horizontal waterproofing of the masonry. Capillary absorption and damp transport are determined by the wetting properties of water relative to the material, as well as the structure and distribution of pores in the material. Chemical (injection) methods of secondary horizontal waterproofing are based on the technology of introducing injection liquid into the masonry section, which forms a lock which relies on the mechanism of capillary lumen constriction, hydrophilization, capillary sealing or a combined effect. A vital outcome of secondary horizontal waterproofing in a wall using the injection method is not only limited absorption but also its changed dynamics. The research paper describes the procedure leading to determining a criterion that allows to classify injection agents in terms of their impact on inhibiting capillary transport of damp in construction partitions.
THE SPECIFICS OF THE INSTITUTE OF STATE OFFICIALS' IMMUNITY IN THE LIGHT OF ARMENIAN CONSTITUTIONAL ORDER
Authors: Tadevosyan Aida , Aghabekyan Fenya
Published: July 2024

The article discusses the nature of the institution of immunity as a political and legal concept in international and national law. The authors present the main approaches to the understanding of this concept, its classification, as well as the historical preconditions for its formation as a legal institute.
The authors proceed from the understanding that the comprehension of the institution of immunity should take place exclusively in the context of the political traditions of a particular state, the specifics of a particular legal order, the prevailing understanding of law, legal culture, as well as the specifics of the political and legal, socio-economic, historical and cultural development of a particular society and state.
The authors believe that the institution of immunity is determined only by the official position that a person occupies and the purpose of the proposed protection is to ensure favorable conditions for the effective performance of the official duties of the person, and in this sense, the institution of immunity cannot act as a personal privilege associated with the person of the official. The authors find that the institution of immunity does not act as an absolute legal category and, in the presence of appropriate grounds, is subject to restriction and strictly narrow interpretation, which is also important for a democratic society. The authors believe that, in particular, on issues of disclosure and prevention of crimes against humanity, the immunity of officials should be subject to strict restrictions.
The authors present the main constitutional foundations for the regulation of the immunity of President and parliamentarians within the framework of the constitutional order of the Republic of Armenia, specifically concluding that all international and national legal provisions governing the issue of granting immunity to officials should not be interpreted and applied in a manner that contradicts paragraph 11 of the Declaration of Independence of Armenia and the state-forming values, principles and aims, establishes in the Preamble of the Constitution of the Republic of Armenia.
Selección de hábitat de Nasua nasua (Thomas, 1912) (Carnivora: Procyonidae) en la Reserva Ecológica Manglares Churute
Authors: Carvajal-Quimiz Nathaly
Published: July 2024

El coatí sudamericano (Nasua nasua) es un carnívoro de tamaño mediano, de hábitos diurnos y una especie clave en los ecosistemas por ser dispersor de semillas. Las poblaciones de esta especie en la Costa ecuatoriana están categorizadas como Vulnerable mientras que el conocimiento sobre sus requerimientos ecológicos es escaso. Con esta investigación buscamos evaluar la selección de N. nasua entre tres tipos de hábitats en la Reserva Ecológica Manglares Churute: bosque seco, bosque húmedo y zona de transición, mediante las frecuencias de eventos de fototrampeo. Para determinar la selección de hábitat empleamos el índice de Manly; para establecer diferencias significativas entre los hábitats aplicamos una prueba de Kruskall-Wallis; además, realizamos un análisis de componentes principales entre las variables ecológicas: superficie de muestreo, densidad arbórea, altitud, área basal, cobertura vegetal y la actividad de N. nasua. Obtuvimos 75 registros independientes totales, con un esfuerzo de muestreo de 1003.74 días/trampas y un éxito de captura del 7,5 %); no encontramos diferencias significativas en los registros de N. nasua entre hábitats (p = 0,36); sin embargo, determinamos una mayor selección de hábitat hacia los bosques húmedos (Wi = 0,61), Por otro lado, determinamos que las variables más influyentes fueron el área basal y la cobertura vegetal, que estarían asociadas con un mejor estado de conservación del hábitat, así como una mayor disponibilidad de alimento y refugio, además de una menor interacción con actividades antropogénicas, con lo cual concluimos que la protección de los bosques húmedos de esta reserva es importante para la conservación de esta especie. Nasua nasua debe ser considerado un valor de conservación en la Reserva, por lo que recomendamos estudiar su estado poblacional, fortalecer un sistema de monitoreo y desarrollar programas de educación ambiental en comunidades aledañas para evitar cacería, tráfico de fauna y uso de la especie como carne de monte.
ESTRATEGIAS DIGITALES BAJO EL ENFOQUE CONSTRUCCIONISTA PARA FORTALECER LA LECTURA CRITICA
Authors: Huerta Cruz Alexandra Cecibel , Doylet Washbrum Juan Medardo , Estrella Acencio Lidia Patricia , Gallegos Samaniego Ana Leonor
Published: July 2024

La presente investigación, tiene como objetivo proponer un modelo didáctico con estrategias digitales que ayude a reforzar la lectura crítica en estudiantes universitarios, teniendo como escenario de investigación la Carrera de Educación Inicial de la Facultad de Filosofía de la Universidad de Guayaquil. Como enfoque cualitativo, se recurre al empirismo para evidenciar el hecho fáctico en las aulas de clases, la búsqueda documental bibliográfica a modo de fundamento para avalar la indagación, con el propósito de contribuir a solventar la problemática de la lectura crítica reflejada como herencia en las aulas de educación superior. Los resultados se dirigen a proponer un modelo didáctico intervenido por estrategias digitales, para motivar a los estudiantes universitarios a reforzar la lectura crítica. La teoría construccionista de Papert es elemental para llegar concluir que se debe partir de los esquemas cognitivos del discente para que éste cree su propio conocimiento motivado por sus intereses aprovechando lo que ofrece la sociedad, el rol docente es ser guía constructivista del aprendizaje, disminuyendo el instruccionismo de las tareas. Las IES deben revisar sus currículos con el objetivo de conocer cómo aportan a reforzar la lectura crítica en las competencias del perfil de salida de los futuros profesionales.
Lenin’s Thought on Agricultural Cooperation and Its Practical Enlightenment
Authors: Cui Luo Cui Luo , Zeyun Duan Zeyun Duan
Published: July 2024

农业合作思想是马克思主义理论的重要组成部分之一，列宁将马克思恩格斯的农业合作化理论，同俄国具体实际相结合，促进马克思主义农业合作化思想的俄国本土化进程。列宁发展了马克思农业合作思想，指出农业合作的性质、方式、原则等内容，这也使列宁探索出一条适合俄国国情的社会主义农业发展道路，推进了俄国整体性发展。深入探究列宁农业合作思想中的立场、观点和方法，结合中国农民专业合作社发展情况，应当坚定人民立场、加强组织保障以及改革创新，以促进中国农民专业合作社高质量发展。
Marx’s Thought on the Relationship between Philosophy and Proletariat and Its Practical Enlightenment：Textual Analysis Based on “A Contribution to the Critique of ‘Hegel’s Philosophy of Right’: Introduction”
Authors: Chenlu Wei Chenlu Wei
Published: July 2024

《<黑格尔法哲学批判>导言》（以下简称《导言》）是关于马克思人的解放思想的经典著作之一，是马克思青年时期思想发展过程中的一个重要里程碑。其中关于哲学与无产阶级关系的思想观点，是马克思关于人的解放理论的重要内容。《导言》以人的解放为贯穿全文的主线，先后通过对宗教的批判、对政治的批判、对法哲学的批判，指明了德国进行政治解放的不可能性和人的解放的可能性，提出了实现人的解放的路径——哲学理论与无产阶级革命相结合，哲学与无产阶级分别作为人类解放事业的“精神武器”和“物质武器”完成任务、肩负使命，二者的关系在推进人的解放的过程中表现为：哲学作为人的解放的“头脑”，无产阶级作为人的解放的“心脏”，互相离不开。没有哲学的无产阶级是乌合之众，没有无产阶级的哲学是空中楼阁，唯有两者结合起来，把哲学变为现实，消灭无产阶级，人的解放实践才有现实的实现路径。马克思关于哲学与无产阶级关系的思想观点对今天人类社会的发展和进步仍然具有重要启示意义。
How Can the Daily Life Subject Achieve the Development towards the “Objectification Field Of Self-Being”?—The Support to Peasants’ Subjectivity in Governance of Rural Human Settlement Environment by Heller’s Everyday Life Theory
Authors: Juanping Huang Juanping Huang
Published: July 2024

阿格妮丝·赫勒在其著作《日常生活》中从人本主义哲学立场出发，摒弃传统马克思主义注重宏观领域而忽视微观日常生活领域的观点。她从人们熟悉而又最易忽视的日常生活环境中探寻日常生活主体何以实现向“自在的”对象化领域转向“自为的”对象化领域发展。具体途径有三：一是形成日常生活主体“自为的”个性;二是培养日常生活主体“自为的”理论态度;三是实现日常生活主体“自为的”日常交往。赫勒的理论这对我国农村人居环境整治中如何发挥农民的主体性地位，提高农村人居环境整治的治理具有重要的借鉴性意义。
To Study The Impact Of Performance Management On Organizational Performance In Merino Industries Ltd.
Authors: Arora Dr Richa , Srivastava Dr Nandini
Published: July 2024

Purpose: This study primarily deals with the impact of performance management on organizational performance of Merino Industries Ltd. Managing the performance of the employees working in the organization is one of the hardest challenges the organizations are going through now a days, Performance Management entirely rest on the employee’s commitment, competence and clarity. Design/methodology/approach: During the study, the descriptive research design was conducted to analysis the effect of performance management on organizational performance. Questionnaire was constructed to extract the primary data from the employees working at Merino Industries Ltd. 67 employees were included as the sample for the study. The exploratory factor analysis was done using SPSSv16 with the 26 independent variables resulting in six major factors and four items did not load on any of the six factors, and hence they are removed from further analysis. Findings: Findings of the study suggests that if a well- planned reward exercise and feedback mechanism is followed, the performance management system aids as an important tool for employee motivation and development which in turn leads to better organizational performance. Value: The major groups of interest (i.e. management students, academicians, researchers, practicing managers etc.) will be able to understand the impact of Performance Management on Organizational Performance in Merino Industries in a better way.
Herramientas informáticas: Microsoft Powerpoint
Authors: Mena Palacios José Faustín ,   Universidad Tecnológica del Chocó Diego Luis Córdoba, Mena Waldo Deiner , Palacios Mosquera Harlinton ,   Universidad Tecnológica del Chocó Diego Luis Córdoba,   Universidad Tecnológica del Chocó Diego Luis Córdoba
Published: July 2024

El mundo avanza significativamente en diversos ámbitos, al punto que, en la actualidad, resulta casi imposible el desarrollo de gran parte de las actividades cotidianas sin la presencia de artefactos que permitan llevar a cabo labores tecnológicas de la mejor manera. Los autores de este producto, interpretando la necesidad que embarga a cualquier persona de tener conocimientos sobre informática, al menos esenciales, procedemos a la redacción y estructuración de este libro que contempla aspectos básicos que cualquier persona pueda requerir en su proceso de formación de algunas herramientas informáticas, disponibles en el módulo Microsoft PowerPoint, útil tanto para principiantes como para personas que ya han venido incursionando en este mundo con anterioridad.
Retos del emprendimiento femenino en las comunidades de Tepelmeme y Concepción BuenaVista
Authors: González Beltrán Diana , Jiménez García Martha , Pérez Castillo América Nohemi
Published: July 2024

Las pequeñas y medianas empresas son un importante eslabón del tejido empresarial en cualquier país. Si bien México ha avanzado en materia de equidad de género, las mujeres dueñas de empresas siguen siendo minoría. En el ámbito rural, las barreras que estas encaran para fundar y mantener sus negocios son aún mayores. El objetivo de este estudio es analizar los desafíos que enfrentan las mujeres emprendedoras en dos municipios del estado de Oaxaca en contraste con sus pares hombres. La investigación fue de tipo exploratoria y descriptiva. Para cumplir este objetivo se realizó una entrevista semiestructurada a emprendedoras/es de ambos municipios. Sobresalen como resultados la existencia de brechas de género en cuanto a las limitaciones que enfrentan emprendedores y emprendedoras. Emergieron como principales desafíos para las mujeres: 1) Insuficiente capacitación en temas de emprendimiento, 2) Dificultad para conciliar el trabajo doméstico y de cuidados y el trabajo como emprendedora, 3) Falta de autonomía para tomar decisiones en sus negocios, entre otros. Se concluye que es importante que los gobiernos municipales tomen en cuenta los principales desafíos presentados en esta investigación y que esta constituya una herramienta guía de cómo diseñar los programas y políticas de apoyo al emprendimiento femenino rural.
The kinematic analysis of the straight punch in two ways for amateur boxing players in Jordan
Authors: Raf’at Ald’ily Ra’fat Omar , Abu-Shihab Esam Najeh , Ibrahim Abualtaieb Mohammad Hassan , Alharahsha Qutaiba A. , Abu Aloyoun Ala’a Kh. , Altarawneh Orouba Dheeb , Mohammad Alyasen Qusai Basem
Published: July 2024

This study aimed to identify some kinematic variables (distance between the feet, arm movement, punch speed, punch time, punch distance, ankle angle, knee angle, elbow angle, shoulder angle, pelvis angle) for the straight punch between two methods. The first method: performing a straight punch with the right hand towards the target without changing the distance between the feet and being on a straight line. The second method: performing a straight punch with the right hand towards the target without changing the distance between the feet, and the left foot is ahead of the right foot. A total of 8 amateur boxers in Jordan who were photographed using an iPhone camera at a frequency of 60 frames per second, participated in this study. The researchers downloaded videos on a computer (LAPTOP), which contains the Kinovea software (Kinovea. Setup.0.8.15.), and determined the best attempts for each player by watching the videos. Then, the researchers analyzed the attempts through the kinetic analysis program (Kinovea. Setup.0.8.15.) and extracted the study variables. The shorter the muscle contraction time of the straight punch, the greater the kinetic momentum and speed of the punch in both styles, and the greater the knee angle, the greater the punch and speed of the punch in both styles. Also, momentum and punch speed were better in the second method. We recommend a climatic and other clinical study of the straight stroke. We also recommend to use the second method in the straight punch.