bluuebunny/crossref_metadata_2025 huggingface dataset:
MISDIAGNOSIS OF SPONTANEOUS SPINAL EPIDURAL HEMATOMA IN A PARTURIENT: A CASE REPORT
Authors:   MD, Department of Neurosurgery, Mohammed the VIth University Hospital Center of Marrakesh, Cadi Ayad University, Faculty of Medicine, Marrakesh, Morocco., El Marrakchi Malak , Bellihi Younes ,   MD, Department of Neurosurgery, Mohammed the VIth University Hospital Center of Marrakesh, Cadi Ayad University, Faculty of Medicine, Marrakesh, Morocco., Arrad Yassine ,   MD, Department of Neurosurgery, Mohammed the VIth University Hospital Center of Marrakesh, Cadi Ayad University, Faculty of Medicine, Marrakesh, Morocco., Hajhouji Farouk ,   MD, Department of Neurosurgery, Mohammed the VIth University Hospital Center of Marrakesh, Cadi Ayad University, Faculty of Medicine, Marrakesh, Morocco., Laghmari Mehdi ,   MD, Department of Neurosurgery, Mohammed the VIth University Hospital Center of Marrakesh, Cadi Ayad University, Faculty of Medicine, Marrakesh, Morocco., Ghanane Houssine ,   MD, Department of Neurosurgery, Mohammed the VIth University Hospital Center of Marrakesh, Cadi Ayad University, Faculty of Medicine, Marrakesh, Morocco., Ait Ben Ali Said ,   MD, Department of Neurosurgery, Mohammed the VIth University Hospital Center of Marrakesh, Cadi Ayad University, Faculty of Medicine, Marrakesh, Morocco.
Published: June 2022

Background: Spontaneous spinal epidural hematomais a rare clinical entity. The symptoms can be similar to Guillain Barre Syndrome, especially if it occurs at the cervicothoracic junction. Its pathophysiology is still unknown and seems to be multifactorial, which makes it a challenging situation in terms of diagnosis and treatment, mainly during pregnancy. Case report:a 22-year-old female at 31 weeks of pregnancy presented to the emergencies complaining of the sudden onset of a neurogenic syndrome with the history of influenza like symptoms six days before. Although cerebrospinal fluid analysis showed no abnormalities, the diagnosis of Guillain Barre Syndrome was suspected on the basis of a series of arguments.The next day, her case worsened as she started exhibiting tetraparesis with genital disorders. Emergency Magnetic Resonance Imaging showed a spinal epidural hematoma extending from C5 to C7. The patient underwent an emergency decompressive laminectomy with evacuation of the hematoma. No apparent vascular malformation was objectified. Despite rehabilitation, she still experienced motor sequelae. Conclusion:Each case requires individual and repetitive evaluation with the establishment of a dated diagram in order to minimize the risk of delayed diagnosis and treatment in spontaneous spinal epidural hematoma, mainly during pregnancy.
A PROSPECTIVE ANALYSIS OF RISK FACTORS FOR POST OPERATIVE SURGICAL SITE INFECTION FOLLOWING IMPLANT SURGERY IN CLOSED FRACTURES
Authors: Maravi L.S. , Sirsikar A. , Vidyarthi A.
Published: June 2022

Aims And Objectives:To assess the incidence of postoperative surgical site infection following implant surgery in closed fractures. Â• To determine whether various risk factors & lab investigations are associated with the development of postoperative surgical site infection following implant surgery in closed fractures. Â• To quantify the contribution of risk factors to the probability of postoperative surgical site infection following implant surgery in closed fractures. Materials And Methods:This study entitled Â“A Prospective Analysis of Risk Factors for Post-operative Surgical Site Infection following Implant Surgery in Closed FracturesÂ” was performed in accordance with the ethical standards approved by the Ethical Committee of the institution in the Department of Orthopaedics, N.S.C.B. Medical College, Jabalpur (M.P.). Conclusion:In our study, we conclude that Staphylococcus aureus remains the most important organism responsible for Post-operative surgical site infections in Orthopaedic Implants.
REPORT ON COLOUR ABERRATION FOUND IN WILD ANIMALS AT PENCH TIGER RESERVE, MAHARASHTRA, INDIA
Authors:   Asst. Conservator of Forest, Pench Tiger Reserve, Maharashtra, Deputy Director, Pench TR, FDCM Bhavan, Hingana Road, Nagpur, India, 440 036., Rambhau Deokar Atul
Published: June 2022

Pench Tiger reserve, Nagpur, Maharashtra is 25th Tiger reserve of India, located in central Indian landscape and spreads over 741.41 sq. Km. There are 71 mammal species reported by Zoological Survey of India (ZSI, 2004).The colour coat of animals is general character in morphological features to identify the animals. But sometimes colour variation is observed in wild animals due to variation in melanin pigment concentration cause of various reasons. There are six different terms as per morphological variations found in wild animals as Albinism, Leucism, Piebaldism, Melanism, Hypomelanism and Blue eyed morph (Mahabal, 2019). Out of these, there are three variations as Leucism, Piebaldism, Melanismfound in Pench tiger reserve, Maharashtra in Sambar& Spotted deer.
Parental Anxiety of Perceived Disorder and Application of Concoctions on Infant Pulsating Anterior Fontanelle in the Tamale Metropolis, Ghana
Authors: Wombeogo Michael
Published: June 2022

The study seeks to unearth parental anxiety of perceived disorder and application of concoctions on infant pulsating anterior fontanelle in the Tamale metropolis, Ghana. Pulsation of the anterior fontanelle though a physiological reality of all infants, causes anxiety on the part of parents for fear of the infant suffering some form of harm as a result. A qualitative study which employed the narrative realities of mothers, delving into mothers’ beliefs on the physiologic functionality of the anterior fontanelle and perceived treatment mode commonly employed by mothers. The study revealed that mothers do not have any scientific reason behind the belief system for the application of concoctions on the pulsating anterior fontanelles of their infants. Consequently, the author recommends that the Ghana Health Service, the Teaching Hospitals, and the Municipal and District Health authorities should embark on serious health education on the essence of the fontanelle and demystify some cultural or traditional belief systems around pulsation of the anterior fontanelle. The application of concoctions on infant pulsating fontanelles is just not based on scientific principles known to the people, but it is perceptively done out of fear of the unknown.
Well-being among boarding school students: Academic self-efficacy and peer attachment as predictors
Authors: Mudzkiyyah Lainatul , Wahib Abdul , Bulut Sefa
Published: June 2022

Students in Indonesian boarding schools (pondok pesantren) have longer study hours than those in non-boarding schools. They also interact with the same friends all day. This situation makes them vulnerable to boredom and depression, and they also run the risk of being bullied. Therefore, student well-being in boarding schools needs to be studied further, with peer attachment and academic self-efficacy as predictors. This study aims to examine the effect of peer attachment and academic self-efficacy on the well-being of students attending boarding school. The study uses a quantitative approach with the linear regression method. It involves 284 students at Madrasah Tsanawiyah (Islamic Junior High School), aged between 13-15 years old, selected using the stratified random sampling method. The data collection instruments employed were the Peer Attachment Scale, Academic Self-efficacy Scale, and School Well-being Scale. The result shows that peer attachment and academic self-efficacy significantly affect school well-being (p .01, F = 156.181, effective contribution of predictors = 52.3%). It indicates that peer attachment and academic self-efficacy simultaneously significantly influence well-being among students in boarding schools. Students should improve their peer attachment and increase their academic self-efficacy to live well in boarding schools.
The mediating effect of self-criticism on college students' emotion dysregulation and intention to self-harm
Authors: Jannah Saffirah Rahayu , Yuliadi Istar , Scarvanovi Berliana Widi
Published: June 2022

College students are in a period of instability, which may be stressful and put them at risk of developing the intention to self-harm. This study examines the effect of self-criticism as a mediator in the association between emotion dysregulation and the intention to self-harm. Quantitative research was conducted on 354 students aged 18-23 years, using the disproportionate cluster random sampling technique. The instruments used were an intention to self-harm scale, self-criticism scale, and emotion dysregulation scale. The results from the mediation analysis conducted using the PROCESS program of Hayes shows that self-criticism significantly mediates the association between emotion dysregulation and students' intention to self-harm (ab = .39, BootSE = .05, 95% BootCI [.29 to .48]). Nevertheless, the results also suggest that even after accounting for the mediating effect of self-criticism, emotion dysregulation still positively impacts students' intention to self-harm (c' = .14, p = .017). The implications of the findings provide insights for college students and all the parties involved with them regarding the mechanisms behind the intention to self-harm.
Fecal indicator bacteria diversity and decay in an estuarine mangrove ecosystem of the Xuan Thuy National Park, Vietnam
Authors: Nguyen Thi Mai Huong , Le Thi Phuong Quynh , Hoang Vinh Van , Nhu Da Le , Ha Hoang Thi Thu
Published: June 2022

Mangroves are complex and dynamic ecosystems that are highly dependent on diverse microbial activities. In this study, laboratory experiments and field studies for fecal indicator bacteria (FIB) decay rates are carried out for the first time in the Xuan Thuy Mangrove Forest Reserve of Vietnam. Results show that there are significant differences in bacterial diversity in the water of mangrove areas that have been deforested compared to those which have been planted. The highest mean total coliform (TC) and Escherichia coli (EC) values were found in the natural mangroves (3,807±2,922 and 964±1133 CFU 100 ml−1, respectively). The results indicated that the source of contamination and seasonal changes affect the abundance of fecal bacteria. These results were exceeding by far the safety guidelines for individual, non-commercial water supplies in most of the samples. In the planted mangrove sampling sites, the highest mean Fecal streptococci (FS) values of 1,520±1,652 CFU 100 ml−1 were found. Microbial die-off rates were calculated over 5 days, and observed to be systematically higher for TC than for EC.
A Comparison and Survey on Brain Tumour Detection Techniques Using
MRI Images
Authors: Mahalaxmi Golla , Tirupal T. , Shanawaz Syed , Swarnakar Sandip , Krishna Sabbi Vamshi
Published: June 2022

Despite enormous advances in medical technology, the prognosis of Brain Tumour (BT) remains an extremely time-consuming and troublesome assignment for physicians. Early and precise brain tumour identification gives an effective results and leads to increased survival rate. Within this paper, an examination of various techniques in order of priority to classify clinical images is presented to analyse various research gaps and highlights their costs and benefits. Human mortality can be reduced by using an automatic classification scheme. The automatic classification of brain tumours is a difficult task due to the large spatial and structural variability of the brain tumor’s surrounding region. The latest developments have been investigated in image characterization strategies for diagnosing human body disease and addressing the classification of nuclear medical imaging identification techniques like Convolution Neural Network (CNN), Support Vector Machine (SVM), Histogram technique, K-Means Clustering (K-MC) etc., just as the respective parameters like the image modalities employed, the dataset and the trade-offs have been compared for each technique. Among these techniques, CNN model accomplished the highest accuracy of 99% for two sets of data: Brain Tumour Segmentation (BTS) and BD-brain tumour and a high average susceptibility of 0.99 for all datasets. Finally, the review demonstrated that improving image order strategies with regarding accuracy, sensitivity value, and feasibility for Computer-Aided Diagnosis (CAD) is a significant challenge as well as an open research area.
Synergy Mechanisms of Rhizoma Paridis Saponins on Non-small Cell Lung Cancer:
Segmented Solid Phase Extraction, Bioactivity Screening, and Network Pharmacology
Authors: Liu Chen , Ma Qingyun , Du Ruikun , Chen Menghan , Xing Shuyan , Yang Yong , Rong Rong
Published: June 2022

Background:

Non-small cell lung cancer (NSCLC) is the most common type of lung cancer. Rhizoma
paridis saponins (RPS), the main bioactive ingredients of Paris polyphylla Smith var. yunnanensis (PPY), have been
proved to have remarkable effects on NSCLC cell lines. However, the multi-component synergistic effects and mechanisms
of RPS on NSCLC have not been elucidated.

Objective:

To decipher the multi-RPS synergistic effects and mechanisms against NSCLC based on network pharmacology
combined with segmented solid-phase extraction (SPE) and bioactivity screening method.

Methods:

Firstly, segmented SPE and cytotoxicity assays were performed to screen the RPS-enrichment fraction of
PPY, and the steroidal saponins in it were identified by LC-MS/MS. Then, a network pharmacology analysis was performed
to predict the potential therapeutic targets of RPS on NSCLC. Finally, viable cell counting tests and RT-qPCR
were utilized to verify the synergistic effects and mechanisms of RPS.

Results:

48 potentially active compounds were identified from the 30% MeOH/EtOAc fraction of PPY (30% M/E
PPY). The results of the network pharmacology analysis indicated that RPS exerted joint effects by regulating six key
targets in the PI3K-AKT signaling pathway. In vitro experiments showed that due to the synergistic effects, 30% M/E
PPY at 13.90 μg/mL could exert a stronger inhibitory activity on A549 cells by reducing the overexpression of six hub
genes compared with the parallel control groups.

Conclusion:

This research elaborates on the multi-RPS synergy mechanisms against NSCLC and provides a way to
develop new combination medicines for NSCLC.
The Interrelationship Between FYN and miR-128/193a-5p/494 in Imatinib Resistance
in Prostate Cancer
Authors: Ergün Sercan , Akgün Oğuzhan , Hekim Neslihan Taşkurt , Aslan Senanur , Ari Ferda , Güneş Sezgin , Abur Ümmet
Published: June 2022

Background:

C-KIT is a receptor tyrosine kinase with oncogenic properties overexpressed in PCa cases. Through the use of an alternative promoter, a truncated c-KIT protein (tr-KIT) of 30-50 kDa is generated, lacking the extracellular and transmembrane domain. Tr-KIT promotes the formation of a multi-molecular complex composed by Fyn, Plcγ1 and Sam68. Imatinib blocks the activity of full-length c-KIT but has no effect on tr-KIT. LNCaP is the human PCa cell line that shows tr-KIT overexpression and PC3 does not show tr-KIT overexpression. miR-128/193a-5p/494 are miRNAs targeting FYN, PLCγ1 and SAM68 combinatorily. The question of the study is that: can miR-128/193a-5p/494 be related with imatinib resistance in PCa?

Method:

LNCaP and PC3 cells were treated with imatinib in IC50 doses. Before and after imatinib administration, RNA was isolated and cDNA conversion was performed. By qPCR analysis, expression changes of tr-KIT specific pathway elements and miR-128/193a-5p/494 analyzed before and after imatinib administration.

Results:

After imatinib administration, miR-128/193a-5p/494 were overexpressed statistically significantly in LNCaP cells while they were downregulated statistically significantly in PC3 cells (p<0.05). Also, FYN was upregulated in LNCaP cells (p<0.05) but there was no change in PC3 after imatinib administration.

Conclusion:

Especially upregulation of FYN may sponge miR128/193a-5p/494 and downregulate their transcriptional activity in LNCaP cells having tr-KIT acitivity. So, miR-128/193a-5p/494 may have critical role in imatinib resistance via tr-KIT pathway.
Nf-κb: A Target for Synchronizing the Functioning Nervous Tissue
Progenitors of Different Types in Alzheimer's Disease
Authors: Zyuz’kov Gleb Nikolaevich , Miroshnichenko Larisa Arkad’evna , Chayikovskyi Alexander Vasil’evich , Kotlovskaya Larisa Yur’evna
Published: June 2022

Background:

The efficacy of Alzheimer's disease (AD) treatment can be enhanced by
developing neurogenesis regulation approaches by synchronizing regenerative-competent cell
(RCCs) activity. As part of the implementation of this direction, the search for drug targets
among intracellular signaling molecules is promising.

Objective:

This study aims to test the hypothesis that NF-кB inhibitors are able to synchronize
the activities of different types RCCs in AD.

Methods:

The effects of NF-кB inhibitor JSH-23 on the functioning of neural stem cells (NSCs),
neuronal-committed progenitors (NCPs), and neuroglial cells were studied. Individual populations
of C57B1/6 mice brain cells were obtained by immunomagnetic separation. Studies were
carried out under conditions of modeling β-amyloid-induced neurodegeneration (βAIN) in vitro.

Results:

We showed that β-amyloid (Aβ) causes divergent changes in the functioning of NSCs
and NCPs. Also demonstrated that different populations of neuroglia respond differently to exposure
to Aβ. These phenomena indicate a significant discoordination of the activities of various
RCCs. We revealed an important role of NF-кB in the regulation of progenitor proliferation and
differentiation and glial cell secretory function. It was found that the NF-кB inhibitor causes
synchronization of the pro-regenerative activities of NSCs, NCPs, as well as oligodendrocytes
and microglial cells in βAIN.

Conclusion:

The results show the promise of developing a novel approach to Alzheimer's disease
treatment with NF-кВ inhibitors.
Preventive Effects of Pimpinella anisum L. and Dracocephalum moldavica
L. Hydroalcoholic Extract Against Acute Contrast-induced Nephropathy
Authors: Rafieian-Kopaei Mahmoud , Rafieian Reza , Asgharian Shirin , Rostamian Sahar , Nasri Hamid
Published: June 2022

Background:

Contrast-induced nephropathy (CIN) is nephrotoxicity due to contrast media characterized by elevated serum creatinine levels. The formation of oxygen free radicals is one of the causes of CIN.

Objective:

Given the antioxidant properties of Pimpinella anisum L and Dracocephalum moldavica L, this study aimed to investigate the effects of their hydroalcoholic extracts on kidney tissue histopathology and CIN biochemical factors.

Methods:

In this experimental study, 40 male Wistar rats were randomly divided into four groups: 1) control, 2) contrast agent, 3) P. anisum+contrast agent, and 4) D. moldavica+contrast agent. After the tests, kidney tissue histopathological damages and related biochemical factors were evaluated.

Results:

Kidney tissue damage, levels of aspartate aminotransferase (GOT/AST), alanine aminotransferase (GPT/ALT) and blood urea nitrogen, serum creatinine (P<0.001), and malondialdehyde (P<0.01) of kidney tissue were lower in both extract-treated groups than in contrast agent group, but the decrease in serum MDA was significant only in the group given P. anisum extract (P<0.01). Serum antioxidant capacity was higher in P. anisum+contrast agent group than in the contrast agent group (P<0.01). Kidney tissue antioxidant capacity was significantly higher in the groups given P. anisum and D. moldavica than in the contrast agent group (P<0.01 and P<0.001, respectively). In addition, hydroalcoholic extracts of P. anisum and D. moldavica resulted in a decrease in CIN.

Conclusion:

Given the decrease in CIN by P. anisum and D. moldavica extracts in rats, it seems that these plants are beneficial for people at risk who need to use contrast agents.
Life skills education capacity structure of teacher in the context of current education innovation
Authors: Giang Trinh Thuy , Khanh Mai Quoc , Hong Nguyen Thi Thanh , Hoa Vu Le
Published: June 2022

The current general education innovation has clearly defined the quality and capacity goals that students need to achieve, in which shows the integration of life skills in the requirements of each quality and capacity at each educational level. With this innovation, the requirement on life skills education capacity of high school teachers is set. Thus, training in pedagogical schools should pay attention to developing this capacity for students. The article studies the structure of life skill education capacity of pedagogical students, creating a premise for pedagogical schools to develop this capacity for students, meeting the requirements of reforming the general education program in 2018.
Home Telemonitoring Technology for Patients With Heart Failure: Cost-Consequence Analysis of a Pilot Study
Authors: Apantaku Glory , Mitton Craig , Wong Hubert , Ho Kendall
Published: June 2022

Background

Heart failure (HF) is a costly health condition and a major public health problem. It is estimated that 2%-3% of the population in developed countries has HF, and the prevalence increases to 8% among patients aged ≥75 years. Home telemonitoring is a form of noninvasive, remote patient monitoring that aims to improve the care and management of patients with chronic HF. Telehealth for Emergency-Community Continuity of Care Connectivity via Home-Telemonitoring (TEC4Home) is a project that implements and evaluates a comprehensive home monitoring protocol designed to support patients with HF as they transition from the emergency department to home.

Objective

The aim of this study is to assess the cost of using the home monitoring platform (TEC4Home) relative to usual care for patients with HF.

Methods

This study is a cost-consequence analysis of the TEC4Home pilot study. The analysis was conducted from a partial societal perspective, including direct and indirect health care costs. The aim is to assess the costs of the home monitoring platform relative to usual care and track costs related to health care utilization during the 90-day postdischarge period.

Results

Economic analysis of the TEC4Home pilot study showed a positive trend in cost savings for patients using TEC4Home. From both the health system perspective (Pre TEC4Home cost per patient: CAD $2924 vs post TEC4Home cost per patient: CAD $1293; P=.01) and partial societal perspective (Pre TEC4Home cost per patient: CAD $2411 vs post TEC4Home cost per patient: CAD $1108; P=.01), we observed a statistically significant cost saving per patient.

Conclusions

In line with the advantages of conducting an economic analysis alongside a feasibility study, the economic analysis of the TEC4Home pilot study facilitated the piloting of patient questionnaires and informed the methodology for a full clinical trial.
Content analysis of pre- and postnatal nutrition and exercise mobile apps in the United States and China (Preprint)
Authors: Yu Hongli , He Juan , Li Keqiang , Wen Qi , Lin Jiahui , Szumilewicz Anna
Published: June 2022

BACKGROUND

Mobile applications (apps) are becoming increasingly prevalent as tools for improving maternal health behaviors. However, the recently updated content and quality of these apps remain unknown.

OBJECTIVE

This research investigated the fundamental characteristics, functional modules, and overall quality of maternal apps available in the United States and China to reveal critical nutrition and physical activity gaps.

METHODS

A systematic search was performed in Android and iOS app stores (China and the United States). Apps were eligible if they targeted pregnant or postpartum women, focused on nutrition or physical activity, and had interfaces in English or Chinese. The basic characteristics, functional modules, and overall quality of the apps were evaluated, and differences between apps available in China or the United States were determined using analysis of variance and chi-square tests. Pearson correlations were utilized to investigate links between objective quality and user rating.

RESULTS

A total of 65 maternity-related nutrition and physical activity apps (34 from China and 31 from the United States) were eligible. Among them, 68% (21/31) of US apps and 56% (19/34) of Chinese apps did not provide supporting evidence for their content. A greater number of Chinese apps provided app-based general education modules, namely food nutrition knowledge (n = 0, 0% in the United States vs. n = 30, 88.2% in China). Meanwhile, a greater number of US apps provided exercise modules, namely pregnancy yoga (n = 21, 67.7% in the United States vs. n = 2, 5.9% in China). The objective app quality rating in the United States was lower than it was in China (mean: 3.5, SD: 0.6 in China vs. mean: 3.4, SD: 0.7 in the United States). There was no relationship between the overall objective quality rating and the user rating in either country (rho = 0.11 in China and rho = -0.13 in the United States).

CONCLUSIONS

The characteristics and functional modules of in-store apps for maternal nutrition and physical activity differed between the United States and China. Both countries’ apps, especially Chinese apps, lacked evidence-based information, and there was no correlation between objective quality and user rating. The results therefore suggest that user ratings cannot be used as an objective indicator of app quality and that it is necessary to improve the empirical basis and credibility of apps in both countries.
Optimizing the Quality of Clinical Data in an Australian Aged Care and Disability Service to Improve Care Delivery and Clinical Outcomes: Protocol for an Agile Lean Six Sigma Study (Preprint)
Authors: Troeung Lakkhina , Tshering Gap , Walton Rebecca , Martini Angelita , Roberts Martin
Published: June 2022

BACKGROUND

In Australia, aged care and disability service providers are legally required to maintain comprehensive and accurate clinical documentation to meet regulatory and funding requirements and support safe and high-quality care provision. However, evidence suggests that poor-quality clinical data and documentation are widespread across the sector and can substantially affect clinical decision-making and care delivery and increase business costs.

OBJECTIVE

In the Optimizing the Quality of Clinical Data in an Australian Aged Care and Disability Service to Improve Care Delivery and Clinical Outcomes (OPTIMISE) study, we aim to use an Agile Lean Six Sigma framework to identify opportunities for the optimization of clinical documentation processes and clinical information systems, implement and test optimization solutions, and evaluate postoptimization outcomes in a large postacute community-based health service providing aged care and disability services in Western Australia.

METHODS

A 3-stage prospective optimization study will be conducted. Stage 1 (baseline [T0]) will measure existing clinical data quality, identify root causes of data quality issues across services, and generate optimization solutions. Stage 2 (optimization) will implement and test changes to clinical documentation processes and information systems using incremental Agile sprints. Stage 3 (evaluation) will evaluate changes in primary and secondary outcomes from T0 to 12 months after optimization. The primary outcome is the data quality measured in terms of defects per unit, defects per million opportunities, and Sigma level. The secondary outcomes are care delivery (direct care time), clinical incidents, business outcomes (cost of quality and workforce productivity), and user satisfaction. Case studies will be analyzed to understand the impact of optimization on clinical outcomes and business processes.

RESULTS

As of June 1, 2022, stage 1 commenced with T0 data quality audits conducted to measure current data quality. T0 data quality audits will be followed by user consultations to identify root causes of data quality issues. Optimization solutions will be developed by May 2023 to inform optimization (stage 2) and evaluation (stage 3). Results are expected to be published in June 2023.

CONCLUSIONS

The study findings will be of interest to individuals and organizations in the health care sector seeking novel solutions to improve the quality of clinical data, support high-quality care delivery, and reduce business costs.

INTERNATIONAL REGISTERED REPORT

DERR1-10.2196/39967
The Effect of Resource Complementarity on a Company's Performance Post-Merger and Acquisition in the Southeast Asia Region: The Moderating Role of the Merger and Acquisition Experience
Authors: Prayogi Joni
Published: June 2022

This study examines the effect of resource complementarity on a post-merger and acquisition company's performance, moderated by the bidder's merger and acquisition experience. Resource complementarity is an important aspect that needs to be considered when carrying out mergers and acquisitions (M&A). This study uses a purposive sampling method, which has specific criteria for selecting the sample, while the dataset is cross-sectional. Tests have been conducted on 97 non-financial companies that carried out M&A in Southeast Asia between 2007 to 2017, and their post-M&A performance has been examined. This research’s methodology utilizes a quantitative approach and explanatory variables. The results indicate that resource complementarity has a significant effect on the performance of post-M&A companies. In other words, resource complementarity has a positive and significant effect on changes in the performance of companies after their M&A. The moderation test shows exciting findings, namely, for companies with little experience, the effect of resource complementarity on post-M&A performance is more substantial. This study has practical recommendations for decision-makers. When conducting their M&A, organizations should select targets with complementary resources and not depend on prior experience, since it is not necessarily applicable to the present circumstances. Furthermore, as they integrate feedback systems to relate earlier experiences, the acquisition experience will have a more robust learning impact.
A New Approach of the Tsunami Mitigation Strategies for the City of Banda Aceh, Indonesia
Authors: Agussaini Halis , Sirojuzilam Sirojuzilam , Rujiman Rujiman , Purwoko Agus
Published: June 2022

Ten years after rehabilitating and reconstructing some coastal areas of Banda Ache struck by the tsunami, and the city is currently repopulated, with most of its open land and community ponds converted into settlements. This rise in population needs to be controlled to minimize damages and casualties, assuming the tsunami hits again. Presently, the Banda Aceh City spatial plan for 2029 does not have a clear concept of tsunami mitigation, specifically in the spatial pattern of coastal areas. Therefore, this research aims to remap the vulnerability level of the Banda Aceh City coastal area from the tsunami hazard and determine alternative strategies based on the tsunami level in achieving safe, comfortable, productive, and sustainable spatial planning goals. This starts by analyzing the wave height generated by the earthquake that triggered this natural disaster and mapping the spatial distribution of the area and the tsunami's inundation height. The results showed that the proportionate regions prone to Level-2 tsunami were worse than the 2004 disaster based on the water level markers built in the city. The spatial planning strategies for the coastal area of Banda Aceh City are carried out by determining the level of tsunami-prone and the potential of the area's resources through a new approach of the multi-layer tsunami defence systems by combining sea dike, greenbelt, silvo-fishery, and the elevated road.
Modeling the Potential of Tsunami Hazard in Labuan Bajo Towards A Disaster-Resilient Tourism Area
Authors: Wibowo Mardi
Published: June 2022

In 2019, Labuan Bajo was designated a super-priority tourism destination, but this area is prone to earthquakes and tsunamis. The potential threats of disasters need to be considered when developing the tourism sector. Therefore, this study aims to determine the height and arrival time of tsunami waves based on a worst hypothetical scenario on the north coast of Labuan Bajo and its surroundings. The method used was numerical modelling with open source software TUNAMI F1, which calculated the wave propagation based on linear equations in spherical coordinates based on worst scenarios. The results showed that the Flores back-arc thrust earthquake caused a reasonably high tsunami with a fast arrival time at Labuan Bajo. The wave height of the tsunami around Labuan Bajo, Rinca, and Komodo Island is at least 3 m, but it reaches 8-9 m under certain conditions. Furthermore, its arrival time on the coast of Labuan Bajo is less than 2.5 minutes. This is much faster than those in Aceh (2004), Pangandaran (2006), and Palu (2018). Even though the early warning came 5 minutes after the earthquake, a high level of preparation and awareness is required to create a disaster-resilient tourist area in Labuan Bajo.
Technology Acceptance Model (TAM) For Smart Lighting System in XYZ Company
Authors: Teja Laksana  , Novian Anggis Suwastika  , Muhammad Al Makky
Published: June 2022

This research was conducted to identify and measure the significance of the factors or variables that influence technology acceptance for a smart lighting system built based on the internet of things (IoT) and artificial intelligence (AI) technology implemented in XYZ company. The smart lighting system implemented was a dedicated smart lighting system for office space (more than 20 m2 to 60 m2) to sense the conditions and make automatic adjustments to room conditions. Before mass production, the smart lighting system would be reviewed for its technology acceptance by users using the technology acceptance technology model (TAM). TAM is a method used to identify factors that affect the technology acceptance based on the functionality of the smart lighting system. Based on the smart lighting purposes and conditions from the XYZ company, six variables influencing the acceptance of smart lighting systems, namely reliability and accuracy (RA), perceived ease of use (PEOU), perceived usefulness (PU), attitude toward using (ATU), behavior intention (BI), and actual system use (AU) were proposed. These variables influenced each other and formed eight hypotheses, namely H1, H2, H3, H4, H5, H6, H7, and H8. Using the purposive sampling technique, validity test with product-moment correlation, and Cronbach’s alpha validity test, five hypotheses had a positive and significant effect, namely H1, H4, H5, H6, and H7. The RA variable influenced the PU variable, the PU variable influenced the ATU variable, the PEOU variable affected the ATU variable, the ATU variable influenced BI, and the PU variable affected BI. Meanwhile, the three hypotheses had negative and insignificant impacts, namely H2, H3, and H8. The RA variable did not affect the PEOU, the PEOU variable did not affect the PU, and the BI variable did not affect the AU variable.
A Gender-based Study of Apology Strategies Employed by Indonesian Students
Authors: Irawan Sandyarini Melati , Hardjanto Tofan Dwi
Published: June 2022

This study investigates the apology strategies used by Indonesian university students and examines whether there is any gender difference in the apologies made by these students. The data were collected using Discourse Completion Task (DCT) containing eight situations. The DCT was distributed to 42 English Department students comprising 21 female students and 21 male students. Altogether, 336 apology utterances were collected. The results showed that the students most frequently used a combination of apology strategies (68.4%), especially a combination of Illocutionary Force Indicating Device (IFID) and Explanation or Account of Cause (EoC). Furthermore, there seems to be no difference in the types of strategies used by female and students. Both groups tended to use a combination strategies and IFID. However, in terms of intensity, female students tended to apologize more intensely than the males and this was evident from their more frequent use of apology intensifications.
Making Promises in the TV Series Gilmore Girls
Authors: Anggraini Suci , Hardjanto Tofan Dwi
Published: June 2022

This study investigates the speech act of promising found in the first five episodes of the TV series Gilmore Girls (2000). It categorizes utterances containing promises based on the directness strategies. The direct promising strategy is identified using the IFID of the speech act of promising, that is the performative verb promise, while the indirect promising strategy is identified and categorized into 10 types of indirect promising strategy proposed by Ariff and Mugableh (2013): pure promise, discourse conditional, tautological-like expression, body-part expression, self-aggrandizing expression, time expression, courtesy-like expression, swearing expression, adjacency pair, and false promise.  The results show that the most commonly used strategy was the indirect promising strategy (94.3%) as the characters in the series tend to make promises casually by not using the performative verb promise. Then, pure promise strategy is the most frequently used type of indirect promising strategy (31.3%). In addition, there are two distinctive types of indirect promising strategies found in the TV series, i.e., hidden promise and sarcastic promise strategies. This finding suggests that there are many other ways to make promises besides using the performative verb, promise and the modal verb will since the context of the conversations sometimes indicates future acts that a speaker commits to doing.
"Joe Biden is a corrupt politician!": Impoliteness in Donald Trump’s Tweets
Authors: Izzah Fithrotul , Sembodo Thomas Joko Priyo
Published: June 2022

This study aims at investigating impoliteness strategies in 351 tweets taken from Donald Trump’s personal Twitter account (@realDonaldTrump) from the first presidential debate to the Election Day of the 2020 United States presidential election. The current study employed Bousfield’s (2008) taxonomy of impoliteness strategies to analyze the data. There are 368 occurrences of eleven impoliteness strategies across 351 tweets. The most common impoliteness strategy is use inappropriate identity markers (23.59%), followed by threaten/frighten (21.13%) and condescend, scorn, and ridicule (20.59%). These strategies were employed to attack and discredit Trump’s political opponents as well as attracting prospective voters. On the other hand, two impoliteness strategies, namely hinder/block and enforce role shift, were not identified in the tweets. The results indicate that Donald Trump’s tweets exhibited impoliteness and that it played quite a significant role as a means of political campaign during the 2020 United States Presidential Election.
The Production of Conversational Humor by Flouting Gricean Maxims in the Sitcom The IT Crowd
Authors: Krisdwiyani Ilsa , Hanidar Sharifah
Published: June 2022

This study focuses on the Gricean maxim floutings found in the production of verbal humor by the characters in the show The IT Crowd, seasons one and two. This research aims to identify and classify the flouting of maxims, explain the rhetorical strategies employed, and the functions behind each flouting of the humorous utterances in the sitcom. Qualitative methods were used in analyzing the data, which are the humorous utterances resulted from the maxims flouting found in the first 12 episodes of the series. However, quantitative data is also taken into consideration in the analysis. In the series, a total of 102 occurrences were identified as maxim floutings. The most frequently occurring maxim flouting is of the quality maxim with 56 occurrences (54.90%).The result shows the characters produced verbal humor by flouting the conversational maxims using varied rhetorical strategies. Their most preferred rhetorical strategy is allusion, with 12 occurrences (11.70%) found in the series. It was also discovered that the characters use a variety of rhetorical strategies when they flout the maxims to achieve different communicative goals. The most frequent goal to appear is self-disclosure, with 26 data indicate the speakers flout the maxims to disclose personal information through humor.
Fracture Risk of Sodium-Glucose Cotransporter-2 Inhibitors in Chronic Kidney Disease
Authors: Cowan Andrea , Jeyakumar Nivethika , Kang Yuguang , Dixon Stephanie N. , Garg Amit X. , Naylor Kyla , Weir Matthew A. , Clemens Kristin K.
Published: June 2022

Background and objectives

Sodium-glucose cotransporter-2 (SGLT2) inhibitors have been associated with a higher risk of skeletal fractures in some randomized, placebo-controlled trials. Secondary hyperparathyroidism and increased bone turnover (also common in CKD) may contribute to the observed fracture risk. We aimed to determine if SGLT2 inhibitor use associates with a higher risk of fractures compared with dipeptidyl peptidase-4 (DPP-4) inhibitors, which have no known association with fracture risk. We hypothesized that this risk, if present, would be greatest in patients with lower eGFR.

Design, setting, participants, & measurements

We conducted a population-based cohort study in Ontario, Canada between 2015 and 2019 using linked provincial administrative data to compare the incidence of fracture between new users of SGLT2 inhibitors and DPP-4 inhibitors. We used inverse probability of treatment weighting on the basis of propensity scores to balance the two groups of older adults (≥66 years of age) on indicators of baseline health. We compared the 180- and 365-day cumulative incidence rates of fracture between groups. Prespecified subgroup analyses were conducted by eGFR category (≥90, 60 to <90, 45 to <60, and 30 to <45 ml/min per 1.73 m2). Weighted hazard ratios were obtained using Cox proportional hazard regression.

Results

After weighting, we identified a total of 38,994 new users of a SGLT2 inhibitor and 37,449 new users of a DPP-4 inhibitor and observed a total of 342 fractures at 180 days and 689 fractures at 365 days. The weighted 180- and 365-day risks of a fragility fracture did not significantly differ between new users of a SGLT2 inhibitor versus a DPP-4 inhibitor: weighted hazard ratio, 0.95 (95% confidence interval, 0.79 to 1.13) and weighted hazard ratio, 0.88 (95% confidence interval, 0.88 to 1.00), respectively. There was no observed interaction between fracture risk and eGFR category (P=0.53).

Conclusions

In this cohort study of older adults, starting a SGLT2 inhibitor versus DPP-4 inhibitor was not associated with a higher risk of skeletal fracture, regardless of eGFR.
Ho Chi Minh’s Ideology on Poverty Reduction and Applying in Vietnam Today
Authors: Tri Dr. Nguyen Minh
Published: June 2022

Poverty reduction is a subjective social and economic phenomenon. They exist alongside the development of human societies as a big challenge to all economies. For Ho Chi Minh, poverty reduction is solving problems directly related to people, thereby improving people’s material and spiritual life. Therefore, right from the founding of the country, he paid great attention to the development of policies on hunger eradication and poverty reduction to manage the country and serve the revolutionary cause. Ho Chi Minh’s ideology on hunger eradication and poverty reduction is a system of viewpoints on the purposes, objects, contents, requirements, and forces for poverty reduction. His Ideology on hunger eradication and poverty alleviation is a valuable spiritual asset, paving the way for the revolutionary cause of the Vietnamese nation to achieve great victories. In the cause of renovation in Vietnam, carrying out the task of building and defending the Fatherland, the Party and State have applied and developed Ho Chi Minh’s thought on hunger eradication and poverty reduction to suit the new situation, contributing to victory in the revolutionary cause.
Music Trademark: New Development of Intellectual Property in Digital Economy
Authors: Shuju FU
Published: June 2022

With the vigorous development of digital economy, the enterprise must pay more attention to the Internet instead of totally the traditional way, and new types of trademarks, especially music trademark, can attract the attention of consumers more than traditional trademarks. But situation is different in different countries and international organization. This paper takes China and the European Union as the research objects, and observes the specific standards in the practical operation of registering new trademarks such as music trademarks both in China and in the European Union through studying a large number of cases and analyzing local laws in comparative study. In China, a music that wants to be registered as a trademark needs to have at least three requirements: legitimacy, distinctive and long-term and heavy use. EU and its member states have different requirements for whether a music is allowed to be registered as a trademark. When member states want to make their own trademark law according to the EU law, they have their own domestic practices and customs of the member states so they finally formed the different trademark legal system from each other. However, music is now generally accepted as a registered trademark in the European Union.
Participação social em saúde: limites e potencialidade de conselhos locais de saúde de uma metrópole brasileira
Authors: Cechinel Neuza de Freitas Raupp , Faria Mateus Aparecido de , Ramos Adriana Roese , Giugliani Camila , Rocha Cristianne Maria Famer
Published: June 2022

Este estudo objetiva analisar os motivos associados à participação de usuários em Conselhos Locais de Saúde (CLS) de Porto Alegre, Rio Grande do Sul, por meio de uma pesquisa exploratória de abordagem qualitativa. Foram realizadas entrevistas semiestruturadas e individuais com 14 usuários, conselheiros ou não, associados a seis Unidades de Saúde. O corpus foi tratado a partir da análise de conteúdo. Ao final, foram identificados fatores que dificultam a participação social, como problemas na comunicação, descrédito sobre impacto de conselhos, falta de infraestrutura adequada, horário das reuniões e situações de violência. Paralelo a isso, também verificaram-se aspectos que facilitam a participação, entre eles: contato com trabalhadoras(es) de saúde, posicionamento ético-político, projetos com comunidade e proatividade. Concluiu-se que fatores impeditivos e facilitadores à participação social pertencem a um mesmo conjunto de problemas e estão interligados, complexificando a situação e colocando em questão a própria participação.
Perfil epidemiológico de doenças tropicais negligenciadas no nordeste brasileiro
Authors: Souza Caroline Cruvinel de , Coutinho Akeme Laissa Novais , Andrade Wellen Zane Nunes , Lima Lorrany Junia Lopes de , Nery Joilda Silva , Silva Anekécia Lauro da , Monte Elaine Cristina Barros Rocha do
Published: June 2022

As doenças tropicais negligenciadas são associadas às populações desfavorecidas socioeconomicamente e muitas delas apresentam alta prevalência no Nordeste brasileiro. Diante disso, o objetivo desta revisão de literatura foi descrever o perfil epidemiológico da leishmaniose, da esquistossomose e da doença de Chagas nessa região, bem como os determinantes sociais envolvidos na manutenção dessas doenças. Trata-se de uma revisão narrativa da literatura do tipo descritiva. Foram detectados cem artigos publicados entre 2012 e 2017 nas bases bibliográficas. Desses, 72 foram selecionados para leitura completa. Após leitura integral e aplicação dos critérios de seleção, restaram 39 artigos. Os resultados convergentes para as três doenças estudadas relacionaram-se às condições inadequadas de vida em sociedade, à baixa escolaridade e à organização falha da estrutura habitacional. A partir da descrição do perfil epidemiológico dessas enfermidades, foi possível ratificar que as variáveis sociais são determinantes para a manutenção dessas condições de saúde. Por fim, os fatores identificados neste estudo foram válidos visando a construção do mapeamento de áreas de risco, além de serem importantes para estudantes da área da saúde, uma vez que compõem o acervo de estudos disponíveis e necessários na capacitação de futuros profissionais no enfrentamento de tais problemas sociais.