bluuebunny/crossref_metadata_2025 huggingface dataset:
Single-cell genomics in acquired bone marrow failure syndromes
Authors: Wu Zhijie , Young Neal S.
Published: July 2023

Mechanistic studies of immune bone marrow failure are difficult because of the scarcity of residual cells, the involvement of multiple cell types, and the inherent complexities of hematopoiesis and immunity. Single-cell genomic technologies and bioinformatics allow extensive, multidimensional analysis of a very limited number of cells. We review emerging applications of single-cell techniques, and early results related to disease pathogenesis: effector and target cell populations and relationships, cell-autonomous and nonautonomous phenotypes in clonal hematopoiesis, transcript splicing, chromosomal abnormalities, and T-cell receptor usage and clonality. Dense and complex data from single-cell techniques provide insights into pathophysiology, natural history, and therapeutic drug effects.
Innovations in RNA therapy for hemophilia
Authors: Ragni Margaret V. , Chan Stephen Y.
Published: July 2023

Given the shortcomings of current factor-, nonfactor-, and adeno-associated virus gene–based therapies, the recent advent of RNA-based therapeutics for hemophilia is changing the fundamental approach to hemophilia management. From small interfering RNA therapeutics that knockdown clot regulators antithrombin, protein S, and heparin cofactor II, to CRISPR/Cas9 gene editing that may personalize treatment, improved technologies have the potential to reduce bleeds and factor use and avoid inhibitor formation. These novel agents, some in preclinical studies and others in early phase trials, have the potential to simplify treatment and improve hemostasis and quality of life. Furthermore, because these therapies arise from manipulation of the coagulation cascade and thrombin generation and its regulation, they will enhance our understanding of hemostasis and thrombosis and ultimately lead to better therapies for children and adults with inherited bleeding disorders. What does the future hold? With the development of novel preclinical technologies at the bench, there will be fewer joint bleeds, debilitating joint disease, orthopedic surgery, and improved physical and mental health, which were not previously possible. In this review, we identify current limitations of treatment and progress in the development of novel RNA therapeutics, including messenger RNA nanoparticle delivery and gene editing for the treatment of hemophilia.
Venetoclax with decitabine as frontline treatment in younger adults with newly diagnosed ELN adverse-risk AML
Authors: Xie Jundan , Bao Xiebing , Xue Sheng-Li , Shen Hongjie , Cen Jiannong , Yao Li , Pan Jinlan , Zhu Mingqing , Liu Dandan , Hu Xiaohui , Wu Qian , Zhang Jingren , Dai Haiping , Cao Yanglin , He Xuefeng , Tang Xiaowen , Sun Ai-Ning , Wang Ying , Fu Jianhong , Qiu Huiying , Yang Xiaofei , Chen Suning , Wu Depei
Published: July 2023

Xie et al present results of a multicenter, single-arm phase 2 trial of venetoclax and decitabine as frontline treatment in 42 younger adults (median age 39 years) with newly diagnosed adverse risk acute myeloblastic leukemia (AML). Remission was achieved in 39 of 42 patients (93%), 36 of whom went on to allogeneic stem cell transplant. Efficacy is encouraging, with estimated 12-month overall survival, event-free survival, and duration of response being 82%, 61%, and 65% respectively.
xenoGI 3: using the DTLOR model to reconstruct the evolution of gene families in clades of microbes
Authors: Liu Nuo , Gonzalez Tonatiuh A. , Fischer Jacob , Hong Chan , Johnson Michelle , Mawhorter Ross , Mugnatto Fabrizia , Soh Rachael , Somji Shifa , Wirth Joseph S. , Libeskind-Hadas Ran , Bush Eliot C.
Published: July 2023

To understand genome evolution in a group of microbes, we need to know the timing of events such as duplications, deletions and horizontal transfers. A common approach is to perform a gene-tree / species-tree reconciliation. While a number of software packages perform this type of analysis, none are geared toward a complete reconstruction for all families in an entire clade. Here we describe an update to the xenoGI software package which allows users to perform such an analysis using the newly developed DTLOR (duplication-transfer-loss-origin-rearrangement) reconciliation model starting from genome sequences as input.
Internal growth of women with recurrent miscarriage: a qualitative descriptive study based on the post-traumatic growth theory
Authors: Shin Gisoo , Kim Hye Jin , Kim Sung Hae
Published: July 2023

Background

Unexpected and repeated miscarriages in a woman's life cycle can be a mental and physical burden and lead to post-traumatic stress disorder. However, women may also experience inner growth with such experiences.

Methods

This study was qualitative descriptive research examining the experiences of South Korean women who had recurrent miscarriages three or more times.

Results

The average age of the participants was 34.6 years, and the average number of recurrent miscarriages was 3.87. Additionally, five themes were identified as follows: (1) Confusing as if in muddy water, (2) Self-examination of past daily life, (3) Empathy and comfort in homogeneous groups, (4) Religious beliefs that include the lost fetus, and (5) Transforming for internal growth.

Conclusion

Based on the results of this study, intervention strategies need to be implemented to support the inner growth of women who have experienced recurrent miscarriages.
Does it fit in your pocket? economic burden of PD-1 inhibitors' toxicity in the supplementary health system: evidence from Brazil
Authors: Duarte Hugo Santos , da Veiga Cassia Rita Pereira , da Veiga Claudimar Pereira , Wainstein Alberto Julius Alves , da Silva Wesley Vieira , Drummond-Lage Ana Paula
Published: July 2023

Background

A full understanding of the economic burden associated with treatment-related adverse events (AEs) can aid estimates of the incremental costs associated with incorporating new technologies and support cost-effective economic modeling in Brazil. In this context, the main objective of this work was to evaluate in a real-life database: (i) the direct medical cost of monitoring the occurrence of AEs (CMO); (ii) the direct medical cost of managing an identified AE (CMN); and (iii) the total direct medical cost of monitoring and managing AEs (TMC), in quarterly periods from 0 to 24 months of the monitoring of cancer patients who used a PD-1 inhibitor from the perspective of the supplementary health system in Brazil.

Methods

This study was conducted from the supplementary health system (SSS) perspective and followed the methodological guidelines related to cost-of-illness studies. A bottom-up (person-based) approach was used to assess the use of health resources to monitor and manage AEs during the use of PD-1 inhibitors, which made it possible to capture differences in the mean frequency of the use of health services with stratification results for different subgroups. As the Brazilian SSS is complex, asymmetric, and fragmented, this study used information from different sources. The methodology was divided into three parts: (i) Data Source: clinical management of AEs; (ii) Microcosting: management of the economic burden of AEs; (iii) Statistical analysis: stratification of results for different subgroups.

Results

Analysis of the economic burden of toxicity showed higher CMO costs than CMN in all the periods analyzed. In general, for every BRL 100 on average invested in the TMC of AEs, BRL 95 are used to monitor the occurrence of the AE and only BRL 5 to manage an identified AE. This work also showed that the sociodemographic characteristics of patients, the journey of oncological treatment, and the toxicity profile affect the economic burden related to AE.

Conclusion

This study provided real-world evidence of the economic burden of AEs associated with the use of PD-1 inhibitors in Brazil. This work also made methodological contributions by evaluating the economic burden of AE of PD-1 inhibitors considering the kinetics of toxicity occurrence and categorizing the costs in terms of CMO, CMN and TMC.
Mitochondrial genetic variants associated with bipolar disorder and Schizophrenia in a Japanese population
Authors: Tachi Ryobu , Ohi Kazutaka , Nishizawa Daisuke , Soda Midori , Fujikane Daisuke , Hasegawa Junko , Kuramitsu Ayumi , Takai Kentaro , Muto Yukimasa , Sugiyama Shunsuke , Kitaichi Kiyoyuki , Hashimoto Ryota , Ikeda Kazutaka , Shioiri Toshiki
Published: July 2023

Background

Bipolar disorder (BD) and schizophrenia (SZ) are complex psychotic disorders (PSY), with both environmental and genetic factors including possible maternal inheritance playing a role. Some studies have investigated whether genetic variants in the mitochondrial chromosome are associated with BD and SZ. However, the genetic variants identified as being associated are not identical among studies, and the participants were limited to individuals of European ancestry. Here, we investigate associations of genome-wide genetic variants in the mitochondrial chromosome with BD, SZ, and PSY in a Japanese population.

Methods

After performing quality control for individuals and genetic variants, we investigated whether mitochondrial genetic variants [minor allele frequency (MAF) > 0.01, n = 45 variants) are associated with BD, SZ, and PSY in 420 Japanese individuals consisting of patients with BD (n = 51), patients with SZ (n = 172), and healthy controls (HCs, n = 197).

Results

Of mitochondrial genetic variants, three (rs200478835, rs200044200 and rs28359178 on or near NADH dehydrogenase) and one (rs200478835) were significantly associated with BD and PSY, respectively, even after correcting for multiple comparisons (PGC=0.045–4.9 × 10− 3). In particular, individuals with the minor G-allele of rs200044200, a missense variant, were only observed among patients with BD (MAF = 0.059) but not HCs (MAF = 0) (odds ratio=∞). Three patients commonly had neuropsychiatric family histories.

Conclusions

We suggest that mitochondrial genetic variants in NADH dehydrogenase-related genes may contribute to the pathogenesis of BD and PSY in the Japanese population through dysfunction of energy production.
Assessing Mode of Recurrence in Breast Cancer to Identify an Optimised Follow-Up Pathway: 10-Year Institutional Review
Authors: Horan Jack , Reid Conor , Boland Michael R. , Daly Gordon R. , Keelan Stephen , Lloyd Angus J. , Downey Eithne , Walmsley Adam , Staunton Marie , Power Colm , Butt Abeeda , Duke Deirdre , Hill Arnold D. K.
Published: July 2023

Background

Breast cancer surveillance programmes ensure early identification of recurrence which maximises overall survival. Programmes include annual clinical examination and radiological assessment. There remains debate around the value of annual clinical exam in diagnosing recurrent disease/second primaries. The aim was to assess diagnostic modalities for recurrent breast cancer with a focus on evaluating the role of annual clinical examination.

Patients and Methods

A prospectively maintained database from a symptomatic breast cancer service between 2010–2020 was reviewed. Patients with biopsy-proven recurrence/second breast primary were included. The primary outcome was the diagnostic modality by which recurrences/secondary breast cancers were observed. Diagnostic modalities included (i) self-detection by the patient, (ii) clinical examination by a breast surgeon or (iii) radiological assessment.

Results

A total of 233 patients were identified and, following application of exclusion criteria, a total of 140 patients were included. A total of 65/140 (46%) patients were diagnosed clinically, either by self-detection or clinical examination, while 75/140 (54%) were diagnosed radiologically. A total of 59/65 (91%) of patients clinically diagnosed with recurrence presented to the breast clinic after self-detection of an abnormality. Four (6%) patients had cognitive impairment and recurrence was diagnosed by a carer. Two (3%) patients were diagnosed with recurrence by a breast surgeon at clinical examination. The median time to recurrence in all patients was 48 months (range 2–263 months).

Conclusion

Clinical examination provides little value in diagnosing recurrence (< 5%) and surveillance programmes may benefit from reduced focus on such a modality. Regular radiological assessment and ensuring patients have urgent/easy access to a breast clinic if they develop new symptoms/signs should be the focus of surveillance programmes.
Occupational exposure to dust and respiratory symptoms among Ethiopian factory workers: A systematic review and meta-analysis
Authors: Ashuro Zemachu , Hareru Habtamu Endashaw , Soboksa Negasa Eshete , Abaya Samson Wakuma , Zele Yifokire Tefera
Published: July 2023

Background

Occupational respiratory disorders are a major global public health concern among workers exposed to dust particles in dust-generating workplaces. Despite fragmented research findings on the magnitude of respiratory problems and the lack of a national occupational respiratory disease recording and reporting system at the Ethiopian factory, the prevalence of respiratory symptoms among factory workers were unknown. Therefore, the aim of this meta-analysis was to summarize and pool estimates from studies that reported the prevalence of respiratory symptoms and predictors among Ethiopian factory workers who worked in dusty environments.

Methods

A systematic literature searches were conducted using electronic databases (PubMed, Science Direct, African Journals Online, and Web of Science). The primary and secondary outcomes were prevalence of respiratory symptoms and predictors, respectively. The STATA version 17 was used to analyze the data. A random effect meta-analysis model was used. Eggers test with p-value less than 5%, as well as the funnel plot, were used to assess publication bias.

Results

The searches yielded 1596 articles, 15 of which were included in the systematic review and meta-analysis. The pooled prevalence of respiratory symptoms among Ethiopian factory workers was 54.96% [95% confidence interval (CI):49.33–60.59%]. Lack of occupational health and safety (OSH) training [Odds Ratio (OR) = 2.34, 95%CI:1.56–3.52], work experience of over 5 years [OR = 3.19, 95%CI: 1.33–7.65], not using personal protective equipment (PPE) [OR = 1.76, 95%CI:1.30–2.39], and working more than eight hours per day [OR = 1.89, 95%CI:1.16–3.05] were all significant predictors of respiratory symptoms.

Conclusion

The prevalence of respiratory symptom was found to be high in Ethiopian factory workers. To prevent workers from being exposed to dust, regular provision and monitoring of PPE use, workers OSH training, and adequate ventilation in the workplace should be implemented.
Women’s views about current and future management of Ductal Carcinoma in Situ (DCIS): A mixed-methods study
Authors: Nickel Brooke , McCaffery Kirsten , Jansen Jesse , Barratt Alexandra , Houssami Nehmat , Saunders Christobel , Spillane Andrew , Rutherford Claudia , Stuart Kirsty , Robertson Geraldine , Dixon Ann , Hersch Jolyn
Published: July 2023

Management of low-risk ductal carcinoma in situ (DCIS) is controversial, with clinical trials currently assessing the safety of active monitoring amidst concern about overtreatment. Little is known about general community views regarding DCIS and its management. We aimed to explore women’s understanding and views about low-risk DCIS and current and potential future management options. This mixed-method study involved qualitative focus groups and brief quantitative questionnaires. Participants were screening-aged (50–74 years) women, with diverse socioeconomic backgrounds and no personal history of breast cancer/DCIS, recruited from across metropolitan Sydney, Australia. Sessions incorporated an informative presentation interspersed with group discussions which were audio-recorded, transcribed and analysed thematically. Fifty-six women took part in six age-stratified focus groups. Prior awareness of DCIS was limited, however women developed reasonable understanding of DCIS and the relevant issues. Overall, women expressed substantial support for active monitoring being offered as a management approach for low-risk DCIS, and many were interested in participating in a hypothetical clinical trial. Although some women expressed concern that current management may sometimes represent overtreatment, there were mixed views about personally accepting monitoring. Women noted a number of important questions and considerations that would factor into their decision making. Our findings about women’s perceptions of active monitoring for DCIS are timely while results of ongoing clinical trials of monitoring are awaited, and may inform clinicians and investigators designing future, similar trials. Exploration of offering well-informed patients the choice of non-surgical management of low-risk DCIS, even outside a clinical trial setting, may be warranted.
Von der Gehorsamkeit zur Subjektwerdung
Authors: Bock Florian
Published: July 2023

Der vorliegende Beitrag fragt nach dem Verhältnis von Kindern und Theologie in der katholischen Pastoralliteratur und Religionspädagogik zwischen dem 18. und 20. Jahrhundert. Inhaltlich lässt sich trotz einiger Ungleichzeitigkeiten über diesen Zugriff eine Transformation des Theologisierens nachweisen: nämlich die Entwicklung von der vom Kind eingeforderten Gehorsamkeit zu einer stärkeren Autonomie des Kindes mit dem Ziel der Subjektwerdung.
Proposal and energy/exergy/economic analyses of a smart heat recovery for distillation tower of the Naphtha Hydrotreating Unit of the Petrochemical Plant; designing a low-carbon plant
Authors: Lyu Xiaoyue , Wang Jinyue
Published: July 2023

This paper suggests a novel framework to retrieve the squandered heat of the Naphtha Hydrotreating Unit of the petrochemical plants. In this idea, the distillation tower’s output of the hydrotreating naphtha unit of the plant is employed as the working fluid to run an organic Rankine cycle with benzene. The procedure is evaluated comprehensively from energy, economic and exergetic point of view using Aspen Haysys software. An advanced case study, including sensitivity analysis, is provided for the Bouali petrochemical plant in Iran to realistically indicate the performance of the suggested configuration. The air cooler in the distillation unit of the aforementioned plant removes (squanders) about 3418 kW of energy, which an organic Rankine cycle can recover. Based on the findings, the exergetic and thermal efficiency of the suggested cycle is 82.53 % and 13.28 %, respectively, with a 1,3620kWh/day rate of energy production. According to the exergetic analysis, the ORC turbine has the highest exergy destruction rate of about 178.76 kW. Also, using the distillation tower squander heat as the heat source to the organic Rankine cycle leads to the least exergy destruction rate. Besides, the output exergy ratio of the whole integrated system to its input is 0.907. The suggested integrated system reduces the total energy consumption from 0.4 to 0.29 GJE/tonFeed with a total investment cost of 11.97 M$, in which the turbines have the highest portion of about 11.2 M$. Hence, the suggested plan’s total income is around 31.94 M$/year.
Fock–Goncharov dual cluster varieties and Gross–Siebert mirrors
Authors: Argüz Hülya , Bousseau Pierrick
Published: July 2023

Cluster varieties come in pairs: for any

𝒳

{\mathcal{X}}

cluster variety there is an associated Fock–Goncharov dual

𝒜

{\mathcal{A}}

cluster variety. On the other hand, in the context of mirror symmetry, associated with any log Calabi–Yau variety is its mirror dual, which can be constructed using the enumerative geometry of rational curves in the framework of the Gross–Siebert program. In this paper we bridge the theory of cluster varieties with the algebro-geometric framework of Gross–Siebert mirror symmetry. Particularly, we show that the mirror to the

𝒳

{\mathcal{X}}

cluster variety is a degeneration of the Fock–Goncharov dual

𝒜

{\mathcal{A}}

cluster variety
and vice versa. To do this, we investigate how the cluster scattering diagram of Gross, Hacking, Keel and Kontsevich compares with the canonical scattering diagram defined by Gross and Siebert to construct mirror duals in arbitrary dimensions. Consequently, we derive an enumerative interpretation of the cluster scattering diagram. Along the way, we prove the Frobenius structure conjecture for a class of log Calabi–Yau varieties obtained as blow-ups of toric varieties.
Comparative clinical and placental pathologic characteristics in pregnancies with and without SARS-CoV-2 infection
Authors: Turdybekova Yasminur Gabdulhakovna , Kopobayeva Irina L. , Kamyshanskiy Yevgeniy K. , Turmukhambetova Anar A.
Published: July 2023

Objectives

To compare the clinical and morphological characteristics of the “mother-placenta-fetus” system in high risk pregnant women of three groups: no SARS-CoV-2 infection, mild SARS-CoV-2 infection, and severe SARS-CoV-2 infection.

Methods

A case-control study was performed for all deliveries, at 28 weeks’ gestation or greater, who had standard indications for placental pathologic examination. Three groups were formed: (1) control group (no SARS-CoV-2 infection), (2) mild SARS-CoV-2 infection, (3) severe SARS-CoV-2 infection. High-risk pregnancies were registered in all cases in the study groups. The examination of the placenta and the selection of fragments of placental tissue were carried out in accordance with the consensus recommendations of the Amsterdam Placental Workshop Group. The sections were subjected to standard processing and stained with hematoxylin and eosin according to the standard protocol. All cases were reviewed by two pathologists, which did not know any information on pregnancy outcome and clinical data. Statistical analysis was performed using SPSS, p<0.05 was considered statistically significant.

Results

Women with severe SARS-CoV-2 infection had an increased rate of multimorbidity including diabetes, chronic hypertension and obesity (p<0.01) compared with the other groups. Placentas at severe COVID-19 course were damaged by both chronic and acute injuries, in comparison to the mild and control groups (p<0.001). Also an important finding in severe COVID-19 was diffuse necrosis of the villous trophoblast – homogenization, diffuse circular eosinophilic masses surrounding the chorionic villi.

Conclusions

Women with multimorbidity are an “at-risk” subgroup for severe SARS-CoV-2 infection and greater likelihood of both placental damage and perinatal hypoxic-ischemic events. These results suggest that patient education, SARS-CoV-2 disease monitoring and preventive measures would be of benefit to this group.
From verb to epistemic marker: bini in Hamedanian Persian
Authors: Rasekh-Mahand Mohammad , Sabouri Fariba
Published: July 2023

This paper provides data from a regional dialect of Persian, Hamedanian Persian, where a verb is grammaticalized to be used as epistemic modality marker, frequently used in interrogatives. The verb didan, objectively means ‘to see’, but subjectivized in many instances to mean ‘understand’. However, in this dialect, bini, originally the subjunctive second person singular form of the verb didan ‘to see’, is used as epistemic marker. It is used in content and polar questions, where uncertainty is a common feature. Our fieldwork data show that the verb didan is used rarely to mean ‘to see’ and it extended to mark epistemic modality, used as probability marker. This modal marker is only used in questions, which share the stance of uncertainty with epistemic markers. The various features of this grammaticalization path are discussed and an explanation based on egophoricity is provided.
DEVELOPMENT of OAT-BASED SNACK PASTES with HONEY and COCONUT (COCOS NUCIFERA L.) OIL
Authors: GÜMÜŞ Pınar , UÇAN TÜRKMEN Filiz
Published: July 2023

Coconut oil has become popular as functional food as the consumer awareness is increasing. Snacks are preferred due to many health benefits. The aim of this study was to compare the effect of the use of honey and coconut oil on the antioxidant, physicochemical and sensory properties of snack pastes. Snack paste containing honey-coconut oil (1:0) was coded Type A, containing honey-coconut oil (1:1) was coded Type B and containing honey-coconut oil (0:1) was coded Type C. This study was observed that there were no significant differences with respect to total phenolic content among snack pastes (P >0.05). Although the difference between A and B samples was statistically insignificant with respect to pH values (P >0.05), there were significant differences among snack pastes with respect to water activity and titratable acidity (P <0.05). It was concluded that snack paste containing coconut oil can be used as an alternative to snack paste containing honey.
Morphological and chemical nature of fiber strands of oil palm empty-fruit-bunch (OPEFB)
Authors: Law Kwei-Nam , Wan Daud Wan Rosli , Ghazali Arniza
Published: July 2023

In this work we examined the morphological and chemical characteristics of the fibrous strands of oil palm empty-fruit-bunch which were left behind after being stripped of their fruits used for oil production. The empty-fruit-bunches were mechanically loosened to yield the fibrous strands, which can be used in paper and board making. We found that the fibrous strands had unique structure by having several large-diameter, long vessel elements in their core region, surrounded by vascular fibers. They had numerous silica-bodies attached to craters on their surfaces; the craters were perforated at the bottom. Many other minerals were also present in the strands. Our microscopic observations suggested that the silica-bodies are connected to a network of siliceous pathway within the fibrous matrix, and minerals tend to concentrate adjacent to the silica-bodies. Our findings could be useful in identifying suitable techniques for processing the oil palm fiber strands into value-added products.
Nationalsozialistische Schulverwaltung in Hamburg
Authors: Schmidt Uwe
Published: July 2023

Nach dem Machtwechsel in Hamburg wurde am 8. März 1933 die Schulverwaltung dem Deutschnationalen und späteren Nationalsozialisten Karl Witt unterstellt. Umgestellt auf das nationalsozialistische Führungsprinzip wurde sie in zunehmendem Maße für die Durchsetzung nationalsozialistischer Erziehungsvorstellungen instrumentalisiert. Diese wurden vor allem über die Personen durchgesetzt, welche die Behörde leiteten oder aber durch informell ausgeübte Macht dominierten. Verdeutlicht wird daher die Position der vier schulbezogenen Funktionsträger im Macht- und Herrschaftssystem des Hamburger Nationalsozialismus. Neben Karl Witt waren dies die Protegés des Gauleiters und Reichsstatthalters Karl Kaufmann Wilhelm Schulz, Albert Henze und Ernst Schrewe. Ihre Nähe zum Machtzentrum um Kaufmann führte zu sehr unterschiedlichen formalen wie informellen Verankerungen in den Mechanismen des polykratischen nationalsozialistischen Systems. Der politische Druck, der von der Spitze der Schulverwaltung auf die Schulen ausgeübt wurde, verstärkte sich seit Kriegsbeginn und erreichte seinen Höhepunkt in der Machtfülle und rücksichtslosen Machtausübung des nationalsozialistischen Senatsdirektors und Gauschulungsleiters Albert Henze.
Findbuch des Bestandes Abt. 47.1
Authors: Asmussen Georg
Published: July 2023

Bei dem vorliegenden Aktenbestand des Universitätskuratoriums handelt es sich nicht um eine einheitlich geführte und von einer Stelle übernommene Altregistratur, sondern um eine Zusammenführung kleinerer und größerer Aktengruppen, die sich je nach der zeitlichen Einordnung des Kuratoriums in die Verwaltung in verschiedenen Aktenbeständen wiederfanden.
‘Forensic Linguistics in Australia: Origins, Progress and Prospects’ Diana Eades, Helen Fraser and Georgina Heydon (2023)
Authors: Grey Alexandra
Published: July 2023

Forensic Linguistics in Australia: Origins, Progress and ProspectsDiana Eades, Helen Fraser and Georgina Heydon (2023)Cambridge University Press. 90 pp.
Thermo-hydraulic numerical modelling of in-soil conditions in reinforced soil walls
Authors: Moncada A. , Damians I. P. , Olivella S. , Bathurst R. J.
Published: July 2023

The role of temperature and relative humidity in long-term mechanical and chemical degradation of polyester fibres due to hydrolysis and creep is well documented. This study presents the results of a thermo-hydraulic 2D finite-element model used to estimate the magnitude and distribution of in situ temperature, relative humidity, and degree of saturation in the backfill of reinforced soil walls (RSWs) due to changes in atmospheric boundary conditions. Boundary conditions for in-air temperature, relative humidity and daily precipitation were taken from weather databases for continental, Mediterranean, desert, and tropical climates. Scenarios with different water tables, and permeable or impermeable zones around the reinforced soil zone were analyzed. Numerical outcomes show that mean in-soil temperature values can be related to the mean annual atmospheric value for each geographical location, with relevant fluctuations limited to the first 3 m of distance from the vertical and horizontal boundaries. In-soil relative humidity values depended on the climate dataset and the permeability of the zones adjacent to the reinforced soil. The results of this study and lessons learned are a valuable precursor for future studies of coupled thermo-hydro-mechanical modelling of polyester geosynthetic RSWs under in situ operational conditions.
The reminders for dental clinics in the COVID-19 post-pandemic era
Authors: Huei-Chu Cheng , Sin-Yen Hsieh , Ya-Ai Cheng , Yueh-Tzu Kao
Published: July 2023

Introduction: The impacts of COVID-19 are enormous and global-wide. Especially, medical treatment activities have been canceled or postponed to avoid the risk of contracting the virus. To prevent the transmission of the COVID-19, methods including early screening, isolation, mass mask use, etc. were applied during the pandemic. Due to the high percentages of vaccination and public policies, the transmission of COVID-19 is under-control. Main text: For dental care settings, researchers have proposed guidelines for the highest-risk group of healthcare professionals to mitigate the possibility of COVID-19 transmission. Nowadays, patients are flowing to reschedule dental appointments which have been canceled or postponed during the pandemic because of the proper control of COVID-19 transmission. Some dental clinics take certain steps to ensure the safety of patients as well as the treatment team. Conclusion: Some reminders are offered to the dental administrator to keep vigilant while providing quality service for the needed patients.
Primary paraspinal hydatid cyst with intraspinal extension. A rare case report
Authors: Saman Anwar , Ayesha Shayan , Hina Naseer , Azzan Mujahid , Rabia Ahmed , Bushra Shamim
Published: July 2023

Hydatid cyst is a zoonotic disease caused by Echinococcus granulosus. It rarely presents in the musculoskeletal system. Primary hydatid disease in paraspinal muscles is very rare. It can be discovered as an incidental finding in radiological imaging. Symptomatic patients are presented with usually symptoms secondary to the compression effect. It can cause dreadful consequences like erosion of adjacent bones, myelopathy, and cauda equine syndrome if left untreated. We present such a case of Primary Paraspinal Cyst with Intraspinal Extension, and its radiological imaging findings, including X-ray, CT scan, and MRI.
Participación ciudadana activa en la redacción de los Planes Generales de Ordenación Urbana de las grandes ciudades españolas
Authors: Artés-Hernández Victoria , Blancafort Jaume , Reus Patricia
Published: July 2023

In response to the growing interest of governments in involving citizens in public policies, this paper studies the degree of citizen participation in the revision of master urban plans during the last 20 years in the 25 most populated Spanish municipalities. For this purpose, the documentation available on the Internet portals of the city councils and in the online newspaper library has been analyzed. The objective is to determine the degree of citizen involvement in municipal planning. Since 2001, of the 25 cities analyzed, 18 have drawn up or are in the process of developing a new urban plan, and 12 have applied or plan to apply additional participation on top of the minimum legal requirement. This finding evidences a considerable effort by these municipal administrations to actively involve their citizens in the revision of their plans beyond what is required by law.
Comparison of Axillary Versus Rectal Temperature Timing in Canine and Feline Patients
Authors: Beyer Olivia , Lueck Ashlynn , Brundage Cord Michael
Published: July 2023

Research on alternatives to rectal thermometry in canine and feline patients has focused on equipment and measurement location but not procedure duration. In a cross-over designed clinical scenario, we evaluated the time prior to and after (Pre-TempT and Post-TempT) rectal and axillary thermometry in canine (n = 114) and feline (n = 72) patients. Equipment duration was controlled for to determine a presumptive total time (TTime) associated with each thermometry method. Pre-TempT and TTime was significantly shorter in axillary thermometry trials for both canine and feline pets (P < 0.001). There was no difference in Post-TempT between thermometry methods in canine patients (P = 0.887) however, the Post-TempT was longer in felines after axillary thermometry (P = 0.004). Reductions in Pre-TempT and TTime were not significant in Scottish Fold breed cats and within the feline rectal trials, the TTime of domestic-long hair breeds was significantly longer than domestic-short hair breeds (P = 0.019). No other tested parameter played a significant role in these results. Axillary thermometry was faster than rectal thermometry in both canine and felines pets due primarily to the time associated with animal approach and restraint (Pre-TempT). These results have implications when optimizing clinic workflow, appointment durations and patient handling time.
Separation of Materials Containing Rare Earth Elements Using Screening and Magnetic Separation
Authors: Baron Rafał , Friebe Paweł , Matusiak Piotr , Kowol Daniel , Lutyński Marcin , Suponik Tomasz
Published: July 2023

This article presents research on selected materials with the aim of determining their rare earth element (REE) content and attempting to intensify it. The test material was coal slurry, which is a waste product from the operation of a preparation plant of a closed coal mine. Research on REE concentration intensification tests was carried out using magnetic separation. Laboratory analyses determining the REE content in the samples obtained, were carried out using the inductively coupled plasma ionisation mass spectrometry (ICP-MS) technique. Carrying out this research by the KOMAG Institute of Mining Technology, is a continuation of work related to making mining waste economically useful and determining a new source of REE recovery. Previous research and development work showed REE content (scandium 40.49 ppm) in the coal slurries studied. The result of the work carried out is the determination of the economic utility of REE recovery from the studied waste.
A mixture of essential oils from three Cretan Aromatic Plants inhibits SARS-CoV-2 proliferation: A Proof-of-Concept intervention study in ambulatory patients
Authors: Lionis Christos , Petelos Elena , Linardakis Manolis , Diamantakis Athanasios , Symvoulakis Emmanouil , Karkana Maria-Nefeli , Kampa Marile , Pirintsos Stergios A , Sourvinos George , Castanas Elias
Published: July 2023

Introduction: The need for therapeutic regimens for non-critically ill patients during the COVID-19 pandemic remains unmet. Previous work has shown that a combination of three aromatic plants’ essential oil (CAPeo) (Thymbra capitata (L.) Cav., Origanum dictamnus L., Salvia fruticosa Mill.) has remarkable in vitro antiviral activity. Given its properties, it was urgent to explore its potential in treating mild COVID-19 patients in primary care. Methods: 69 adult patients were included in a clinical, Proof-of-Concept (PoC) intervention study. Family physicians implemented the observational study in two arms (intervention and control group) during three study periods (IG2020, n=13, IG2021/22, n=25 and CG2021/22, n=31). The SARS-CoV-2 infection was confirmed by real-time PCR. The CAPeo mixture, was administered daily for 14 days, per os in the intervention group, while the control group received usual care. Results: The PoC study, found that the number and frequency of general symptoms, including general fatigue, weakness, fever and myalgia, decreased following CAPeo administration. The average presence (number) of symptoms decreased in IG (4.7 to 1.4) as well as in CG (4.0 to 3.1) by Day 7 compared to Day 1, representing a significant decrease in cumulative presence in IC (-3.3 vs. -0.9, p<0.001; η2=0.20) on Day 7 and on Day 14 (-4.2 vs. -2.9, p=0.027; η2=0.08). Discussion/Conclusion: Our findings suggest that CAPeo, possesses potent antiviral activity, in addition tο the Influenza A and B and the human rhinovirus HRV14 strains against SARS-CoV-2. The early and effective impact in alleviating key symptoms of COVID-19 may suggest this mixture can act as a complementary natural agent for mild COVID-19 patients
Mineral and Geochemical Features of Sulfide in Jade Hydrothermal Field of Okinawa Trough
Authors: Wang Yujie , Zeng Zhigang
Published: July 2023

In this paper, mineralogical and elemental geochemical characteristics of massive sulfide samples collected from Jade hydrothermal field, located in the Izena depression in the central graben of Okinawa Trough, were analyzed by means of optical microscopy, scanning electron microscopy and electron probe. The results show that the sulfide in Jade hydrothermal area can be divided into Zn-Cu-Pb rich massive sulfide and Zn-Fe rich massive sulfide. The former is composed of sphalerite, galena, anglesite, chalcopyrite and pyrite, and its formation stage can be divided into pyrite stage, sphalerite-chalcopyrite stage, anglesite stage and colloidal pyrite stage. The latter is mainly composed of sphalerite, pyrite, marcasite and a small amount of galena, which can be divided into galena stage, pyrite stage, sphalerite stage, pyrite and marcasite stage. Cu and Zn in pyrite may exist in the form of microinclusions, while Ag and Pb may exist in pyrite in the form of fine galena inclusions containing Ag. Fe and Cu may enter sphalerite in the form of ion replacement. Zn may enter chalcopyrite in the form of ion replacement, and As and Pb may be inclusions in chalcopyrite as As-bearing galena inclusions. Consistent with the previous understanding, the metal elements in the hydrothermal liquid system in Jade hydrothermal field mostly migrate with the hydrothermal fluid as sulfur complexes, and when the hydrothermal fluid mixes with seawater, the physical and chemical conditions of the fluid change, resulting in sulfide mineral precipitation. However, the chemical structure of chalcopyrite is still controversial, which restricts the understanding of the substitution mechanism of trace elements during chalcopyrite precipitation.
Grape Derived Polysaccharide Extracts Rich in Rhamnogalacturonans-II as Potential Modulators of White Wines Flavour Compounds
Authors: Canalejo Diego , Martínez-Lapuente Leticia , Ayestarán Belén , Pérez-Magariño Silvia , Doco Thierry , Guadalupe Zenaida
Published: July 2023

Most authors have investigated the role of mannoproteins on wine quality but very few analyze the use of grape derived polysaccharides as they are not commercially available. Purified grape derived polysaccharides from red wine (WPP) and winemaking by-products (DWRP: Distilled Washing Residues Polysaccharides) were used as potential fining agents to modulate white wine flavour. Phenolics and volatile compounds were analyzed in control and wines treated with WPP, DWRP and commercial mannoproteins (CM) after one and twelve months of bottling, and a sensory analysis was conducted. WPP and DWRP, rich in rhamnogalacturonans-II, showed as good modulators of wine aroma and astringency. Improvement of wine aroma was related to an increase of all volatile families expect higher alcohols and volatile acids. The modulation of astringency and bitterness was related to a reduction in the proanthocyanidin content and its mean degree of polymerization. Extracts with polysaccharides with higher protein contents presented higher retention of volatile compounds, and DWRP extract showed more positive effects on the overall aroma. Our novel results open the possibility of obtaining valuable polysaccharides from distilled washing residues of wine-pomaces, which could promote its valorization as by-product. This is the first time to describe the potential use of this by-product.
Cancer and Diabetes Predictive Factors in Patients with Metabolic Syndrome
Authors: Stan Mihai Cosmin , Georgescu Daniel , Mirestean Camil , Bădulescu Florinel
Published: July 2023

Abstract: Background and Objectives: A growing number of epidemiologic studies have found that diabetes mellitus may increase cancer risk and is implicated in numerous other metabolic and inflammatory disorders. The increase in pro-inflammatory cytokines plays a major role in insulin resistance and leads to hypoalbuminemia, and micro- and macrovascular diabetes complications, including kidney disease and anemia. This study aimed to investigate the utility of CEA, CRP, serum albumin level, hemoglobin, and LDH as biomarkers for cancer risk and the biological implications of diabetes on the evolution and prognosis of oncological patients. Material and methods: We conducted a retrospective, longitudinal, observational study, on a total group of 434 patients, 217 diagnosed with a form of cancer and with type 2 diabetes as a comorbidity, and the other 217 – control group, without diabetes. These patients were admitted to the oncology clinic. In subgroups, the same number of patients was considered, depending on the location of the oncological pathology. Anemia, hypoalbuminemia, elevated lactate dehydrogenase, glycated hemoglobin, and C-reactive protein levels are more pronounced in subjects with type 2 diabetes and cancer. Conclusions: The presence of diabetes negatively affects the clinical and biological prognosis of cancer patients.
Exploring the Interrelationships Between Diabetes, Nutrition, Anxiety, and Depression: Implications for Treatment and Prevention Strategies
Authors: Basiri Raedeh , Seidu Blessing , Rudich Mark
Published: July 2023

Diabetes and mental disorders have been recognized as two significant public health concerns globally. Recent research indicates that there is a bidirectional relationship between these two conditions, with each influencing the other's course and outcomes. Nutrition plays an essential role in the prevention and treatment of both mental disorders and diabetes. A comprehensive review of existing literature was conducted to examine the impact of anxiety and depression on the development of diabetes and the influence of diabetes on the occurrence of mental health disorders such as anxiety and depression. Additionally, the effects of nutrition on the prevention and management of mental disorders, diabetes, and related complications in at risk individuals were assessed. Our findings show that mental disorders, such as depression and anxiety increase the risk of developing type 2 diabetes and are associated with poorer glycemic control, increased diabetes-related complications, and higher mortality rates. Conversely, diabetes is also linked with an increased risk of developing mental health disorders, including depression, anxiety, and cognitive decline. The biological, psychological, and social factors that contribute to the comorbidity between these two conditions are complex and multifaceted. Therefore, an integrated approach to the management of both conditions is critical for improving patient outcomes and reducing the overall burden of disease. Nutritional interventions should be utilized to reduce the risk of diabetes in patients with anxiety and depression as well as enhance mental health in patients with diabetes.
The Structural and Electrochemical Properties of CuCoO2 Crystalline Nanopowders and Thin Films: Conductivity Experimental Analysis and Insights from Density Functional Theory (DFT) Calculations
Authors: Chfii Hasnae , Bouich Amal , Andrio Andreu , Torres Joeluis Cerutti , Soucase Bernabé Mari , Palacios Pablo , Lefdil Mohammed Abd , Compañ Vicente
Published: July 2023

A novel manufacturing process is presented for producing Nano powders and thin films of CuCoO2 (CCO) material. This process utilizes three cost-effective synthesis methods: hydrothermal, sol-gel, and solid-state reactions. The resulting delafossite CuCoO2 samples were deposited onto transparent substrates through spray pyrolysis, forming innovative thin films with a Nano crystal powder structure. Prior to the transformation into thin films, CuCoO2 powder was first produced using a low-cost approach. The precursors for both powders and thin films were deposited onto glass surfaces using a spray pyrolysis process, and their characteristics were examined through X-ray diffraction, scanning electron microscopy, HR-TEM, UV-visible, and Electrochemical impedance spectroscopy (EIS) analyses was conducted to determine the conductivity in transversal direction of this groundbreaking material for solar cell applications. On the other hand, the sheet resistance of the samples was investigated using the four probe-method to obtain the sheet resistivity and them calculate the in plane conductivity of the samples. We also investigated the aging characteristics of different precursors with varying durations. The functional properties of CuCoO2 samples were explored by studying chelating agent and precursor solution aging periods. Resuming, this study thoroughly discusses the synthesis of delafossite powders and their conversion into thin films, which hold potential as hole transport layers in transparent optoelectronic devices.
Evaluation of Back Extrusion Test Precision and Sensitivity for Cooked Germinated Brown Rice Texture Measurement in Production Process
Authors: Kaewsorn Kannapot , Maichoon Pisut , Pornchaloempong Pimpen , Krusong Warawut , Sirisomboon Panmanas , Tanaka Munehiro , Kojima Takayuki
Published: July 2023

The texture properties of cooked rice are a dominant property which can indicate the eating quality. Evaluation of back extrusion (BE) test precision and sensitivity for cooked germinated brown rice (GBR) texture in production process was investigated in this study. BE test on texture properties of cooked GBR rice show high precision of measurement of hardness, toughness and stickiness tests which indicated by the repeatability and reproductivity test but the sensitivity indicated by coefficient of variation of the texture properties. The findings of the study of the effect of different soaking and aging duration in the production of Khao Dawk Mali 105 (KDML 105) GBR on cooked GBR texture measured by BE test confirmed the developed protocol for evaluation of high precision and sensitivity of the texture measurement method. Repeatability and reproducibility of reliable measurements have a low standard deviation of the farthest different between replicates, which is considered high precision. High coefficient of variation where the relative wide variation of the absolute value of the property can be detected indicate high sensitivity which even small resolution can be detected or vice versa. But the correlation coefficient among the texture properties by BE were not related to the precision or sensitivity of the test. By these results, the original protocol for determination of precision and sensitivity of food texture measurement was successfully verified as the usable evaluation protocol for GBR texture measurement.