bluuebunny/crossref_metadata_2025 huggingface dataset:
Esthetics of the maxillary frontal group in dental prosthetics
Authors: Olariu I. , Olariu T. , Popovici R. A. , Cosoroaba R. M. , Pitic (Cot) D. E. , Pașca C. , Flueraș R. , Ilieș I.
Published: November 2024

The esthetics of the maxillary front group is a crucial aspect in dental prosthetics, having a significant impact on the patient's smile and confidence. Modern prosthodontics offer various treatment options, including all-ceramic crowns, dental veneers, and dental bridges made of esthetically superior materials such as zirconia and feldspathic ceramics. The article highlights the importance of the multidisciplinary approach in the restoration of the maxillary frontal group, involving the collaboration between dentists, dental technicians and, in some cases, specialists in plastic surgery and orthodontics. Particular attention is paid to minimally invasive techniques, which allow the preservation of the natural tooth structure, while maintaining long-term aesthetics and functionality.
Oral health: Knowledge and practices among high school students
Authors: Beresescu L. , Negrea M. , Stoica A.M. , Tohati C. , Benedek C.
Published: November 2024

Oral health is a crucial aspect of general well-being, affecting essential bodily functions and psychosocial factors. Aim and objectives: This study aimed to assess and compare the oral health knowledge and practices of high school students in Târgu Mureș. Materials and Methods: This cross-sectional survey involved 592 high school students. The study used a 43-question online questionnaire covering socio-demographic data, oral health knowledge, hygiene habits, and dental service use. Results: The study found a good level of oral health knowledge among students. However, gaps were identified in specific areas like the role of fluoride, alcohol-related risks, and emergency dental procedures. Financial status and gender influenced knowledge and attitudes, with higher financial status and female students showing better awareness. Conclusions: High school students demonstrated good oral health knowledge, but there is a need for targeted education to fill knowledge and practice gaps.
Ang 15-Point Labor Agenda at ang Pagkakaisa ng Kilusang Paggawa sa Pilipinas
Authors:   Federation of Free Workers, Cainglet Julius
Published: November 2024

Ang pagkakaisa ng kilusang ng paggawa sa Piipinas ay pinanday ng higit isang daan taon ng pakikibaka at paglaban sa pang-aapi ng mga kapitalista, naghaharing uri at dayuhang monopolyo kapital. Subalit sa maraming pagkakataon, kinatatampukan din ito ng mga tunggalian at malalim na hidwaan sa loob mismo ng kilusan. Mailap ang pagkakaisa. Ang pagkakaiba sa ideolohiya, pulitika, maging sa paraan ng paggawa at mga personal na katangian ng mga lider manggagawa, at panunulsol ng mga tiwaling opisyal, kapitalista at mass media na kontrolado nito, ay mga salik na pumupigil sa pagkakaisa ng mga manggagawa.
Relationship Between the Youth’s Perspectives on Suicide and Their Suicide-Related Experiences
Authors:   University of the Philippines Diliman, Quintos Mark Anthony
Published: November 2024

This study sought to determine if there is a relationship between the suicide experiences of the youth (no prior suicide experience, experience of suicide ideation but not attempts, and experience of suicide attempts) and their perspectives on suicide. Undergraduate university students (n=308) were engaged as participants in the study. Data were obtained through a survey questionnaire and were analyzed through correlational tests. Findings showed a very salient divide in the perspectives about suicide between those with no prior suicide experience and those with experience of suicide attempts. The former tend to have very conservative views on suicide to the point that they prefer not to talk about the topic and downplay the prevalence of the phenomenon but nonetheless believe that it is a human duty to stop someone from committing suicide. The latter tend to have very liberal views that lean towards the acceptance of suicide and assisted suicide. These two groups and their diverging views present two possibilities that Philippine society may take. On one hand, suicide may
be downplayed as an issue but may nonetheless have the people with the right conviction necessary for suicide prevention. On the other hand, suicide and assisted suicide may be more accepted in Philippine society such that socio-cultural, legal, and medical impediments to the act may be relaxed. The direction of suicide-related responses, including legislation and regulation/prevention, that Philippine society will eventually take may be dependent on how prevalent suicide attempts will be in the succeeding years.
#SulitDeals, Pero Lugi si Rider? Ilang Pagtatasa Ukol sa Lumalaking Gig Economy sa Pilipinas
Authors:   Polytechnic University of the Philippines, Gianan Emy Ruth
Published: November 2024

Existing digital delivery platforms such as Grab, FoodPanda, Angkas, and Lazada brought comfort and ensured speedy services to its users. While they offered innovative service solutions, a more incisive analysis shows that these platforms create more harm than good. Work structures and its overall value are diminishing, and delivery riders are not getting decent pay, proper support, and actual benefits even if they are the main service providers in these platforms. This paper intends to examine various studies on platform or gig economies, and collate and analyze the issues that directly affect delivery riders. These findings will serve as foundations to develop policy recommendations designed to significantly improve the conditions of delivery riders, alongside a critical review of Department of Labor and Employment (DOLE) Labor Advisory No. 14-21. To this end, the study is hinged on the pandemic manifesto “Democratizing Work” by Isabella Ferreras — gigworkers should not be seen differently from traditional conceptions of work. As such, policies intent on improving the gig economy should be geared towards social justice and securing the rights of Filipino workers.
Perception and Cognition of COVID-19 and Its Dietary Implications A prospective Study in Bangladesh
Authors: Biswas Bipul
Published: November 2024

Background: The COVID-19 pandemic has profoundly affected public health, influencing perceptions, cognitive responses, and dietary behaviors globally. In Bangladesh, where socioeconomic diversity is high, understanding these changes is essential for public health planning. Objective: This study aimed to assess the perception and cognition of COVID-19 among the Bangladeshi population and to examine the association between these factors and changes in dietary behavior during the pandemic. Method: A cross-sectional multicenter study was conducted from June 2020 to June 2021 across various regions in Bangladesh. A total of 4,116 participants were recruited using stratified random sampling. Data were collected through structured questionnaires evaluating participants' perceptions, cognition regarding COVID-19, and changes in dietary habits. Statistical analyses, including chi-square tests and logistic regression, were used to assess associations, with significance set at p < 0.05. Results: The study found that 62.8% of participants perceived COVID-19 as a severe health threat, which significantly influenced dietary behavior. Specifically, 49.3% of respondents reported an increased consumption of fruits and vegetables, while 32.7% increased their intake of processed foods. Participants with higher COVID-19 awareness were 1.8 times more likely to increase their consumption of immunity-boosting foods (p = 0.03). Additionally, 54.1% of those with a strong cognitive understanding of COVID-19 reduced their intake of unhealthy foods, compared to 29.4% with lower understanding (p = 0.01). Conclusions: The perception and cognition of COVID-19 significantly influenced dietary behaviors in Bangladesh. Enhancing public understanding of COVID-19 is crucial to promoting healthier dietary practices during pandemics.
Finansowanie zielonej rewolucji za pomocą umów power purchase agreement
Authors:   Akademia Techniczno-Humanistyczna w Bielsku Białej, Michalski Dariusz , Hawranek Paweł ,   HAWRANEK Kancelaria Radców Prawnych Spółka Partnerska
Published: November 2024

W artykule poruszono istotne zagadnienia związane z finansowaniem inwestycji w OZE za pomocą umów PPA. Należy przewidywać dalszy rozwój zielonej energetyki, który będzie ściśle związany z rozwojem zielonych finansów. Atrakcyjność energii z OZE wynika z prognoz dotyczących wzrostu konkurencyjności OZE w stosunku do energii elektrycznej z elektrowni konwencjonalnych. Autorzy wskazali także w artykule na wzrastającą istotność ryzyka klimatycznego, które staje się impulsem dla rozwoju zielonych finansów, kreujących instrumenty reakcji na to ryzyko, kreując jednocześnie zapotrzebowanie na finansowanie inwestycji w OZE. W rezultacie obniżenia kosztów inwestycji OZE stają się najtańszymi sposobem rozwoju mocy wytwórczych w elektroenergetyce na świecie. Sprawia to, że na wielu rynkach zakup energii z OZE na potrzeby dużych zakładów przemysłowych jest konkurencyjny w stosunku do tradycyjnej elektroenergetyki. Zakup energii elektrycznej z OZE pozwala także zabezpieczyć się przed wahaniami cen wywołanymi nie tylko zmianami cen paliw kopalnych, lecz także praw do emisji gazów cieplarnianych czy wpływu na ceny energii polityki ochrony zmian klimatu. Ponieważ wytwarzanie energii elektrycznej nie jest działalnością podstawową zakładów przemysłowych, trudno jest uzyskać zgodę właścicieli na realizację inwestycji w OZE. Stąd coraz popularniejsze staje się wykorzystanie instrumentów PPA, które nie są związane z inwestycjami kapitałowymi i budową
aktywów trwałych. Istotne jest, że umowy PPA zapewniają płynność rynku zabezpieczenia ryzyka rynkowego w długim okresie, znacznie dłuższym niż płynność rynku terminowego. Stąd w artykule omówiono także specyfikę różnych rodzajów kontraktów PPA oraz ryzyka, jakie są z nimi związane.
Prawo wodorowe – ocena wybranych planów legislacyjnych
Authors:   Wydział Prawa i Administracji Uniwersytetu im. Adama Mickiewicza w Poznaniu, Dragan Dagmara
Published: November 2024

Dnia 14 stycznia 2021 r. Ministerstwo Klimatu i Środowiska opublikowało projekt Polskiej Strategii Wodorowej, która jako jedno z głównych zadań do realizacji w zakresie rozwoju gospodarki wodorowej w Polsce stawia stworzenie stabilnego otoczenia regulacyjnego, w związku z czym polski rząd zapowiedział przygotowanie ustawy – Prawo wodorowe, która ma uregulować działanie rynku wodoru w sposób kompleksowy. Jednocześnie w strategii wymieniono i pokrótce opisano kilka obszarów, które będą stanowić obszar regulacji podjętej w ustawie – Prawo wodorowe. Niniejszy artykuł ma na celu przedstawienie tych obszarów oraz ocenę zaproponowanych zmian legislacyjnych pod kątem zarówno ich wpływu na rozwój gospodarki wodorowej w Polsce, jak i spójności z planami Komisji Europejskiej przedstawionymi w lipcu 2020 roku.
Nakaz zaprzestania wydobycia węgla brunatnego w kopalni Turów nałożony w ramach środków tymczasowych zarządzonych w sprawie C-121/21 R (postanowienie Wiceprezes Trybunału Sprawiedliwości z dnia 21 maja 2021 r.)
Authors:   Akademia Leona Koźmińskiego w Warszawie, Kolegium Prawa, Zawodziński Konrad
Published: November 2024

Postanowieniem z dnia 21 maja 2021 r. w sprawie C-121/21 R Wiceprezes Trybunału Sprawiedliwości nakazała zaprzestanie wydobycia węgla brunatnego w kopalni Turów. Orzeczenie zapadło w sprawie ze skargi Republiki Czeskiej o uchybienie zobowiązaniom państwa członkowskiego przez Rzeczpospolitą Polską. Sprawa ilustruje podejście Trybunału do oceny wiarygodności skargi oraz pilności zabezpieczenia. O ile nie budzi wątpliwości możliwość ustanawiania tymczasowej ochrony prawnej w sprawach ze skarg o stwierdzenie uchybienia zobowiązaniom państwa członkowskiego, zastrzeżenia budzi fakt, że sposób zabezpieczenia określony przez Trybunał Sprawiedliwości wykracza poza dozwoloną treść merytorycznego orzeczenia kończącego postępowanie.
Solidarność energetyczna jako ogólna zasada prawa Unii Europejskiej
Authors:   Kolegium Prawa Akademii Leona Koźmińskiego w Warszawie, Zawodziński Konrad
Published: November 2024

Wyrokiem z dnia 15 lipca 2021 r. w sprawie C-848/19 P Trybunał Sprawiedliwości (wielka izba) utrzymał w mocy wyrok Sądu Unii Europejskiej (powiększonego składu pierwszej izby) z dnia 10 września 2019 r. w sprawie T-883/16 dotyczący zmiany reżimu regulacyjnego gazociągu OPAL. Orzeczenie zapadło w sprawie z odwołania Republiki Federalnej Niemiec od wyroku, uwzględniającego w całości skargę Rzeczpospolitej Polskiej o stwierdzenie nieważności decyzji Komisji Europejskiej z 2016 r. C(2016)6950 zatwierdzającej – w zasadniczej części – krajowy akt stosowania prawa (niem. Vergleichsvertrag, dosł. umowę ugody) sporządzony z udziałem niemieckiej Federalnej Agencji Sieciowej (niem. Bundesnetzagentur). Tym samym przesądzono, że solidarność energetyczna stanowi zasadę prawną, zaskarżalną, będącą wzorcem kontroli sądowej, podstawą skutecznych zarzutów procesowych. Potencjalnie może być ona źródłem ograniczeń autonomii proceduralnej (autonomii środków) na szczeblu krajowym, a swoim znaczeniem objąć nie tylko przejawy działalności regulacyjnej, lecz także inne decyzje w dziedzinie energetyki, w szczególności z zakresu prawa konkurencji oraz monitorowania inwestycji zagranicznych. Treść zasady wymagać będzie doprecyzowania, wyróżnić natomiast należy jej wymiar proceduralny i instytucjonalny (m.in. współpraca organów, odpowiednio szerokie umożliwienie realizacji prawa do bycia wysłuchanym) oraz wymiar materialnoprawny (test przeciwstawnych interesów i zasady rozwiązywania wyłaniających się konfliktów).
„Dievo Sūnaus“ sąvoka autentiškuose Pauliaus Laiškuose
Authors: Kumža Egidijus , Skinkaitis Rimas
Published: November 2024

Straipsnyje analizuojama apaštalo Pauliaus vartota „Dievo Sūnaus“ sąvoka, priskiriama Jėzui Kristui. Šiandieninėje visuomenėje, ieškant įvairių dvasinių potyrių, labai svarbu tiesiog atsigręžti į patį Dievą, kurį galima sutikti Jėzaus Kristaus asmenyje. Straipsnyje, remiantis Šventojo Rašto egzegeze, teologijos žodynais, teologų autorių raštais, siekiama skaitytoją supažindinti su Jėzaus kaip Dievo Sūnaus samprata, kurią pateikė apaštalas Paulius. Išryškėja, kad Jėzus Kristus yra ne tik žmogus, bet tarpininkas tarp žmonių ir Dievo, atpirkėjas, turintis išskirtinį artumą ir giminingumą su Dievu – šis ryšys yra giminystės, o ne įvaikinimo. Paulius, vartodamas Sūnaus sąvoką, nurodo ne tik prieš-egzistuojantį pasaulio atpirkėją, kuris tapo žmogumi ir yra jo skelbimo objektas, bet ir tą, kuris užbaigia sukūrimo istorijos darbą.
Ethnobotany, phytochemistry, and biological properties of three naturally associated Mediterranean species
Authors: Benamar Khadija , Koraichi Saad Ibnsouda , Fikri-Benbrahim Kawtar
Published: November 2024

Chamaerops humilis (C. humilis), Olea europea var Sylvestris (O. oleaster), and Asparagus albus (A. albus) are three plant species native to the Mediterranean basin. They are often associated in nature. In different countries of the Mediterranean area, they are used in folk medicine in order to treat several ailments, such as urinary, digestive, respiratory, neurologic, and metabolic diseases. The numerous traditional therapeutical uses of these three plant species have led to the completion of several studies demonstrating scientifically their biological activities. However, as regards A. albus, only a few studies were carried out in this context. This review has the objective of documenting and analyzing different works concerning the ethnomedicinal uses, chemical composition, and bioactive potential of these three medicinal plants, in order to provide researchers with a global database of biological properties that have been demonstrated and to identify gaps for further studies. The electronic databases used for data collection are Google Scholar, Pub Med, Pub Chem, Science Direct, and Scopus. The results of this study show that thanks to their richness in bioactive compounds, C. humilis, O. oleaster, and A. albus exhibit several biological activities that can be exploited in the medical and agro-food fields.
Syndecan-1 as a therapeutic target in squamous cell carcinoma: Current insights and future directions
Authors: Files Rita , Cardoso Cláudia , Prada Justina , Silva Filipe , Pires Isabel
Published: November 2024

Squamous cell carcinoma (SCC) is a type of epithelial cancer that originates in the squamous epithelium and can develop in any area of the body covered by this tissue. Cutaneous SCC is characterized by a locally aggressive tumor, highlighting the importance of identifying new therapeutic targets to combat this disease effectively. Syndecan-1, a molecule often deregulated in cutaneous SCC, is a type 1 transmembrane proteoglycan primarily expressed in epithelial and plasma cells. The ectodomain of Syndecan-1 is frequently shed, rendering the molecule soluble and capable of interacting with various other molecules. This review aims to comprehensively analyze Syndecan-1 expression in cutaneous squamous cell carcinoma (CSCC), elucidate its role in tumorigenesis, and assess promising therapeutic strategies that target Syndecan-1 and its associated pathways. Therapeutic approaches often focus on molecules that facilitate the shedding of the Syndecan-1 ectodomain, such as matrix metalloproteinases (MMPs) and heparanase. Inhibition of heparanase and MMPs has shown potential in preventing the degradation of Syndecan-1 and reducing tumor invasiveness. Additional strategies include using synthetic proteoglycans, peptide mimetics such as syntenin, and overexpression of the C-terminal fragment of Syndecan-1 to suppress tumor growth and migration. Moreover, targeting microRNAs that regulate Syndecan-1 expression presents another promising therapeutic tool. These therapies are designed to modulate the function of Syndecan-1, potentially affecting the progression of CSCC and improving clinical outcomes.
Psychometric Properties of the Spanish Version of the Parental Feeding Style Questionnaire
Authors: Martínez-Hernández Irene , Olmos-Soria Marina , Fonseca-Pedrero Eduardo , Dolores Hidalgo María , Valero-García Ana V.
Published: November 2024

Background::
There are no validated instruments in Spain for measuring parental feeding styles. The aim was to validate the Parental Feeding Styles Questionnaires (PFSQ) in a Spanish sample.

Method::
A total of 523 mothers of 523 school-children participated. The children had a mean age of 4.4 years ( = 1.3), with 51% being boys ( = 4.3 years, = 1.4) and 49% girls ( = 4.5 years, = 1.3). The PFSQ and the Comprehensive General Parenting Styles Questionnaire (CGPQ) were used.

Results::
A model of four correlated factors was identified: Prompting/encouraging eating, emotional feeding, instrumental feeding, and control over eating. Cronbach's alpha for the subscales ranged from 0.64 to 0.86, and McDonald's Omega coefficient ranged from 0.66 to 0.86. Emotional feeding and prompting/encouraging eating had values above 0.70, control over eating had a value of 0.68 and instrumental feeding had an alpha coefficient of 0.64 and omega coefficient of 0.66. The factor structure was similar to the original and to other adapted versions. The Spanish sample used more control over eating and prompting/encouraging to eat.

Conclusions::
The adapted PFSQ is a suitable instrument for assessing the feeding styles of Spanish parents.
Telephone-Based Psychological Care During the 2020 Lockdown in Spain and Protocol for Data Collection
Authors: Carpallo-González María , Nuñez-Rubines Ana M. , Limonero Joaquím T. , Fernández-Berrocal Pablo , Muñoz-Navarro Roger
Published: November 2024

Background: :
During the COVID-19 lockdown in 2020, the General Council of Psychology in Spain, together with the regional Official Colleges of Psychology, launched the Psychological Care Telephone Program (PCTP) to provide mental health services to the population.

Method: :
The aim of the present study was to perform a descriptive analysis of the PCTP by analysing the data collected during the lockdown and at the 12-month follow-up, and to develop a brief protocol designed to standardise data collection procedures.

Results: :
A total of 10,119 inbound telephone calls were made to the PCTP from March to May 2020, and 337 follow-up calls at 12 months. The most common reasons for contacting the PCTP were to consult for symptoms of anxiety (66.8%), depression (30.5%), and/or family problems (13.9%). At the 12-month follow-up, many users experienced anxiety (38%), depressive (35%), and panic (34%) symptoms. More than half of users reported using psychopharmacological medicines.

Conclusions::
This study demonstrates the need to offer the population telephone-based mental health consultations during times of crisis. It also shows the importance of systematising intervention and data collection procedures for future crises. We propose a data collection protocol for use with emergency telephone psychological assistance programmes.
Nighttime Fears and Coping Responses in School-Aged Children: A Latent Profile Analysis
Authors: Fernández-Martínez Iván , Orgilés Mireia , Espada José Pedro , Tomczyk Samuel , Morales Alexandra
Published: November 2024

Background::
Nighttime fears are common among school-aged children and may be linked to psychological difficulties, while coping strategies may vary and affect their emotional well-being. This study aimed to identify patterns of nighttime fears and coping styles in school-aged children using Latent Profile Analysis. Subsequently, possible predictors of the latent profiles were tested through multinomial logistic regression analysis.

Method::
A sample of 786 Spanish-speaking children (aged 8 to 12;
= 9.66, = 1.20; 51.3% girls) participated and completed self-report measures of nighttime fears and coping responses.

Results::
The results revealed four latent profiles: (1)“low fears, low self-control” (24.2%), (2)“high fears (except for imaginary fears), maladaptive coping” (22.8%), (3)“moderate fears, adaptive coping” (44.9%), and (4)“high fears, maladaptive coping” (8.1%). The regression analysis revealed that sociodemographic characteristics and children’s perceived helpfulness of coping strategies were predictors of the latent profiles.

Conclusions::
These findings suggest the presence of distinct patterns and heterogeneous subgroups, which may emerge as higher or lower risk profiles. It highlights the need to consider the existing patterns to provide tailored interventions targeting nighttime fears.
Suicidal Behavior and Social Cognition: The Role of Hypomentalizing and Fearlessness About Death
Authors: Andreo-Jover Jorge , Fernández-Jiménez Eduardo , Bobes Julio , Isabel Cebria Ana , Crespo-Facorro Benedicto , De la Torre-Luque Alejandro , Díaz-Marsá Marina , García-Ramos Adriana , Grande Iria , González-Pinto Ana , Jiménez-Treviño Luis , Roberto Natalia , Ruiz-Veguilla Miguel , Palao-Tarrero Ángela , Pérez-Sola Víctor
Published: November 2024

Background: :
Suicide attempt (SA) lethality is associated with heightened suicidal desires and social cognition deficits. Fearlessness about death (FAD) and hypomentalizing may play a role in SA and self-harm. Although studies have identified relationships between these constructs, this line of research is still limited. We aimed to explore the mediating role of FAD and mentalizing between suicidal ideation and both SA lethality and self-harm.

Method: :
1,371 suicide attempters (70.1% women; = 40 years) from seven Spanish hospitals participated. We used the Fearlessness About Death (ACSS-FAD) subscale, the Reflective Functioning Questionnaire-8 (RFQ-8), and the Columbia Suicide Severity Rating Scale (CSSRS). We conducted serial multiple mediation analyses with suicidal ideation as exposure; FAD and mentalizing as mediators; SA lethality and self-harm as outcomes.

Results: :
Indirect effects were found of suicidal ideation on self-harm ( = 0.08, = 0.03-0.15) and SA lethality mediated by FAD ( = 0.02, = 0.001-0.04); indirect effects of suicidal ideation on self-harm through mentalizing ( = 0.10, = 0.04-0.167), and total indirect effects between suicidal ideation and self-harm through FAD and mentalizing ( = 0.18, = 0.11-0.27).

Conclusions: :
Interventions addressing mentalizing and FAD may help reduce SA lethality and self-harm risk.
Entre os muros da exclusão
Authors: Moraes Sepúlveda Patrick
Published: November 2024

Este livro analisa a trajetória de três internos do Asilo São João de Deus, situado na cidade de Salvador, durante as primeiras décadas do século XX. Por meio de fontes como periódicos, processos crimes e cíveis, foi possível compreender aspectos sociais, culturais e cotidianos de suas experiências de vida sob diversos aspectos.
Pereskia bleo augments NK cell cytotoxicity against triple-negative breast cancer cells (MDA-MB-231)
Authors: Khalaf Taif Kareem , Ismail Norzila , Nazri Nor Amalia , Ahmed Naveed , Yajid Aidy Irman , Mohamud Rohimah , Kadir Ramlah
Published: November 2024

Background

Natural killer cells (NK cells) are essential in cancer immunosurveillance in the body as they can recognize cancer cells that lacking MHC class 1 on their surface. Regulatory cytokines, including interleukin (IL)-18, IL-12, IL-10, IL-8, interferon-γ (IFN-γ), and secretory granules like perforin and granzyme are involved in NK cell-mediated cytotoxicity. Stimulating NK cells cytotoxicity towards cancer cells is an ideal strategy to combat cancer naturally. Medicinal plants have been reported to enhance immunity, with Pereskia bleo (P. bleo) particularly noteworthy due to its abundant bioactive compounds and ability to activate immune cells. This study aimed to evaluate the potential of methanol extract of P. bleo leaves (MEPB) for enhancing NK cell cytotoxicity against triple-negative human breast cancer cells (MDA-MB-231).

Methods

The optimal concentration of MEPB to activate NK cells was determined using healthy blood samples, assessing the expression of IL-12, IL-18, IL-10, IL-8, IFN-γ, perforin, and granzyme B via an enzyme-linked immunosorbent assay (ELISA). NK cell purity from healthy donors and breast cancer patients was determined using specific antibodies, and the number of NK cells was assessed using flow cytometry and a hemocytometer. A co-culture experiment, ELISA, and apoptosis assay were used to evaluate NK-mediated cytotoxicity pathways.

Results

ELISA data indicated that MEPB at 7.5 µg/ml significantly increased the expression of IFN-γ, IL-12, IL-18, perforin, and granzyme B while decreasing IL-8 and IL-10 expression after 20 hrs of incubation. The average NK cell purity was 87.09 ± 0.043%. Breast cancer patients exhibited lower NK cell counts than healthy donors. Co-culture experiments demonstrated that NK cells induced apoptosis in MDA-MB-231 breast cancer cells in the presence of MEPB by increasing perforin, granzyme B, and IFN-γ expression in both healthy donors and breast cancer patients-experimental groups. P. bleo enhances NK cell activation, promoting the apoptosis of triple-negative human breast cancer cells (MDA-MB-231), suggesting the potential use of MEPB leaves as an anti-cancer immunostimulant.
A comprehensive review of oncogenic Notch signaling in multiple myeloma
Authors: Roosma Justin
Published: November 2024

Multiple myeloma remains an incurable plasma cell cancer with radical case-by-case heterogeneity. Because of this, personalized and disease-specific biology of multiple myeloma must be understood for the discovery of effective molecular targets. The highly evolutionarily conserved Notch signaling pathway has been extensively described as a multifaceted driver of the multiple myeloma disease process—contributing to both intrinsic effects of malignant cells and to widespread remodeling of the tumor microenvironment that further facilitates disease progression. Namely, Notch signaling amongst malignant cells promotes increased proliferation, tumor-initiating capacity, drug resistance, and invasiveness. Moreover, Notch signaling between malignant cells and cells of the tumor microenvironment leads to increased osteodegenerative disease and angiogenesis. This comprehensive review will discuss both the intrinsic implications of pathological Notch signaling in multiple myeloma and the extrinsic implications of Notch signaling in the multiple myeloma tumor microenvironment. Additionally, the genetic origins of Notch signaling dysregulation in multiple myeloma and current attempts at targeting Notch therapeutically will be reviewed. While the subject has been reviewed previously, recent developments in the intervening years demand a revised synthesis of the literature. The aim of this work is to introduce and thoroughly synthesize the current state of knowledge in this vein of research and to highlight future directions for both new and in-the-field scientists.
Modelo de caracterización de alternativas para el apoyo de target value delivery y su impacto en el diseño del proceso de construcción
Authors:   , Guzmán Zambrano Cristóbal Emilio José
Published: November 2024

Se ha establecido que la efectividad de las implementaciones de Target Value Delivery (TVD) se ve profundamente afectada por la consistencia en la aplicación del método. Esta investigación aborda esta falta de consistencia, la necesidad de dinamismo en la evaluación de alternativas y la brecha en los modelos tradicionales de estimación de costos frente a TVD, que ignoran las implicaciones en el costo de los cambios en los procesos entre las diferentes alternativas de diseño y tienen problemas para adaptarse a la naturaleza iterativa de TVD y su proceso de toma de decisiones. La investigación se enfoca en el desarrollo de un modelo de caracterización de alternativas (MCA) diseñado específicamente en torno a las prácticas y requerimientos de TVD. El MCA entrega una caracterización monetaria (o estimación de costos) y una caracterización no monetaria para apoyar el proceso de toma de decisiones a través de Choosing by Advantages (CBA). Se aplica Design Science Research (DSR) para desarrollar el modelo utilizando un proyecto habitacional en Chile como caso de estudio. Tras cinco iteraciones TVD se alcanzó una reducción de costos cercana al 7%. Los resultados muestran que el modelo entregó estimaciones con la rapidez y precisión necesaria para las iteraciones en TVD. El modelo también facilitó una base de datos de alternativas constructivas, que puede ser utilizada para estimaciones y comparaciones más allá del análisis económico. Se observó que las discusiones generadas en los clusters interdisciplinarios de TVD influenciaron el diseño del proceso de producción. Las limitaciones de la investigación surgen del hecho de que las principales decisiones respecto a la definición del proyecto ya estaban tomadas. Sin embargo, los resultados del modelo sugieren el potencial de una implementación más temprana de TVD. Otra limitación recae en el desarrollo y aplicación en el contexto específico del caso de estudio. Investigaciones futuras pueden desarrollarse sobre la aplicación del modelo en otros contextos. También, se discutió que el modelo prepara el camino para la adopción de otras prácticas de Integrated Project Delivery (IPD), indicando la necesidad de una investigación más profunda respecto al tema.
Avaliação da reutilização de resíduos de gesso como estratégia para a construção sustentável em Manaus, Brasil
Authors: Moraes Rosalina Siqueira , Alencar David Barbosa de , Nascimento Manoel Henrique Reis , Leite Jandecy Cabral , Moraes Nadime Mustafa
Published: November 2024

O crescimento da população e os progressos da indústria e da urbanização contribuem para o aumento da geração de resíduos, dentre eles, o gesso, e por modificação da Resolução do CONAMA nº 307 o gesso passou a ser categoria B, resíduos que podem ser reciclados ou reutilizados, dessa maneira, a reciclagem dos resíduos de gesso passou a ser obrigatória como também necessária e viável. Neste contexto, visando minimizar o impacto ambiental causado por esses resíduos, este trabalho teve como objetivo inicial de diagnosticar a geração de resíduos de gesso advindos de Construtoras na cidade de Manaus (definidas através de alguns critérios de amostragem) e suas disposições finais, como ainda, avaliar as características técnicas do gesso reciclado produzido em escala piloto, para reinserção na cadeia produtiva da construção civil, visando a sua sustentabilidade, através do processo de reciclagem para o reaproveitamento. O objetivo do presente trabalho é realizar, através de um estudo caso, uma análise acerca das formas de gerenciamento de resíduos de gesso advindos da construção civil, visando o seu reuso, onde pretendem-se apresentar a importância da reciclagem do gesso a partir de seus detritos, além de exibir as possibilidades de reaproveitamento, tendo em vista a redução desses materiais descartados em locais impróprios. Afim de verificar a qualidade do resíduo do gesso reciclado em comparativo com o gesso convencional, no qual, será analisado as suas propriedades e características, verificando o tempo de pega, resistências mecânicas e consistências entre eles, e por conseguinte, propor uma nova aplicabilidade para a cadeia produtiva da construção ecológica, será efetuado ensaios laboratoriais.
Sistema de detecção de resíduos em rios e nascentes utilizando visão computacional e inteligência artificial
Authors: Valente Mateus de Sousa , Coelho Arthur Brenno Ribeiro , Assis Roberto Silva Araujo
Published: November 2024

A poluição de rios e nascentes representa um desafio ambiental crescente, ameaçando a biodiversidade e a saúde humana. O descarte inadequado de resíduos sólidos prejudica ecossistemas aquáticos, contamina reservatórios de água potável e impacta populações ribeirinhas. A industrialização e o aumento urbano intensificam essa situação, tornando insuficientes os métodos tradicionais de monitoramento e limpeza. Soluções tecnológicas avançadas, como inteligência artificial (IA) e visão computacional, surgem como alternativas viáveis para a detecção e remoção automatizada de lixo. A IA permite identificar resíduos em tempo real, com destaque especial para o uso de tecnologias de visão computacional, como o YOLO (You Only Look Once), que representa o estado da arte em detecção de objetos, além do uso de redes neurais e redes adversariais generativas, entre outras tecnologias para auxiliar na identificação e qualificação dos resíduos. Este artigo propõe um sistema de detecção de resíduos que funcione em dispositivos móveis e pequenos computadores, com potencial para integração futura com drones e dispositivos flutuantes, capazes de atuar em áreas remotas com baixo consumo de energia e banda de internet. A seção de resultados revela o desempenho do modelo proposto na tarefa de detecção de resíduos em ambientes subaquáticos, especialmente quando comparado a arquiteturas convencionais, como o YOLOv5. A análise quantitativa demonstra melhorias significativas nas métricas, ratificando que seu uso para detecção e qualificação torna o sistema um grande aliado no combate à poluição.
Zinc Dynamics in Soil, Transport and Assimilation in Plants
Authors: S Sooryalekshmi , Leno Naveen , B. Rani
Published: November 2024

The global population is projected to increase by 25% by 2050, adding approximately 2 billion people, significantly intensifying the demand for food. Ensuring food production and accessibility enriched with essential minerals is crucial to addressing malnutrition. Currently, 2 billion people worldwide suffer from micronutrient deficiencies, with zinc (Zn) deficiency being a critical concern for crops, humans, and animals. Alarmingly, 50% of cultivated soils used for cereal production are Zn-deficient, exacerbating the problem. In plants, Zn is indispensable, contributing to enzyme activation, auxin synthesis, protein production, and maintaining membrane integrity. Natural and anthropogenic sources of Zn include surface water, soil, rocks, industrial activities, agricultural practices, fertilizers, and pesticides. Despite these sources, Zn deficiency remains a widespread issue because only a small fraction of the total Zn in soils is available to plants. This limitation arises from various soil transformation processes, such as sorption by clays, hydrous oxides, and organic matter, which reduce Zn bioavailability. Plants primarily absorb Zn in its divalent cation form (Zn²⁺) from the soil solution. Specialized Zn transporters play a crucial role in facilitating the diffusion of Zn across cell membranes, driven by membrane potential. Once inside, Zn is assimilated into various plant tissues, supporting critical physiological and biochemical processes. However, the limited availability of Zn in soils restricts plant growth and nutrition, ultimately impacting food quality and human health. Addressing Zn deficiency requires targeted strategies, including improving Zn availability in soils and adopting sustainable agricultural practices. Enhanced understanding of Zn dynamics in soil-plant systems can help optimize Zn uptake, contributing to improved crop productivity and addressing the global challenge of malnutrition.
Assessment of Gender Inclusion in Credit Utilization among Farmers in Ondo State, Nigeria
Authors: Akinrotimi Abiodun Festus , Adeyemi Ife Oluwasina , Oladoyin Olanrewaju Peter , Olubunmi-Ajayi Tolulope Seun
Published: November 2024

This study evaluates gender inclusion in credit utilization among farmers in Ondo State, Nigeria. The research aimed to analyze the nature of credit accessed, identify factors influencing credit utilization and access, and assess the constraints faced by male and female farmers. Data were collected from 120 farmers using a structured questionnaire and analyzed using descriptive statistics, linear regression, and logit regression models. Findings revealed that male farmers were more likely to access both formal and informal credit than female farmers, with 79.3% of males applying for credit compared to 42.1% of females. Education was a significant factor influencing credit utilization for both genders, while age, marital status, and farm size also positively impacted credit utilization among female farmers. High collateral requirements, complex application processes, and gender bias were key constraints in accessing credit, particularly for female farmers. The study concluded that education plays a vital role in credit access and utilization, with male farmers generally being more advantaged. Recommendations include government-backed empowerment programs and supervised credit schemes to improve credit access for both genders, especially women, and enhance agricultural productivity.
Portal Cavernoma in Children: Rare Pathology with Complex Management about 3 Cases
Authors: Aithmadouch S. , Radi A. , Larbiouassou K. , Abikassem R.
Published: November 2024

We report 03 cases of portal cavernoma hospitalized in pediatric department. Through these observations, we will try to describe the different clinical and biological aspects and discuss the diagnostic and therapeutic approaches through a literature review. Somatic examination revealed a distended abdomen and hepatosplenomegaly, presence of collateral venous circulation. The diagnostic approach to portal cavernoma in children is based on careful clinical examination, including identification of symptoms such as gastrointestinal bleeding, hepatomegaly and signs of liver disease. The biological work-up showed bicytopenia (microcytic hypochromic anaemia with thrombocytopenia) with a normal blood and liver count. The long-term course of portal cavernoma in children depends on various factors, such as the presence of complications, response to treatment and medical and surgical management. The prognosis is generally better in children who receive regular medical follow-up and appropriate treatment in the event of complications.
Acquisition and Application of 21st Century Skills among Pre-service Social Studies Teachers in Ghana
Authors: Takyi Benjamin
Published: November 2024

It is widely acknowledged that Social Studies can aid students in acquiring essential 21st-century skills. Nonetheless, research on the real-world application of these skills is limited. While some studies have looked at integrating these skills into the Social Studies curriculum and teaching approaches, they have not investigated their use in practical situations. This study aimed to examine how pre-service Social Studies students at the University of Education, Winneba, in Ghana acquire and apply 21st-century skills. A quantitative approach was used with a descriptive survey design. The study included a population of 333 pre-service Social Studies teachers from the Department of Social Studies Education. The respondents were selected through proportionate stratified sampling, and data was gathered using a structured questionnaire. Descriptive statistics and a one-sample t-test were used to analyze the data. The results showed a low level of 21st-century skills acquisition among the respondents, with a mean of mean score of 1.9 (SD = 0.9). The one-sample t-test revealed significant findings across all assessed 21st-century skills, with mean scores consistently below the benchmark of 3.0 (p-value = .00). Although the development of 21st-century skills was limited, the participants applied several of these skills in managing the socio-economic aspects of their lives.
Assessing the Participation of Local Community Members in Schools Managerial Activities and Decisions Making: A Case of Community Secondary Schools in Coast and Kagera Regions, Tanzania
Authors: Ngonge Rweyendera Gosbert
Published: November 2024

This paper explores the participation of local community members in the managerial activities and decision-making processes of community secondary schools in the Coast and Kagera regions of Tanzania. The study objective was to explore the decisions and managerial activities of the school in which local community members were meaningfully involved. Despite the critical role that community involvement plays in enhancing educational outcomes, there is scanty information about the nature of school managerial activities and decision-making the communities are involved in. Through a qualitative approach and case study design data was collected using interviews, and triangulated from school board members, councilors, school heads, village/street leaders, community members, and education officials. The findings reveal that while community members are recognized as key stakeholders, their involvement in decision-making is often limited to passive roles, with real authority concentrated among school board members and heads of schools. External factors such as government policies which do not provide clear guidance and specify mechanisms through which community members can collaborate with the administration of the ward secondary schools hinder effective participation. Thus, this study advocates for collaborative measures between the government and communities to empower both communities and school management, enabling meaningful participation in school governance.
Comparative Analysis of Greedy, Gale-Shapley, and Score-Based Methods for Optimal Project Allocation
Authors: Zhang Ru (Johnny)
Published: November 2024

The project allocation problem is essential in various fields, including academic and organizational settings, where efficient, stable, and satisfying assignments are crucial for maximizing engagement and productivity. This paper presents a comparative analysis of three distinct algorithms for project allocation: the Greedy Algorithm, the Stable Matching Algorithm (Gale-Shapley), and a Score-Based Allocation Method. The Greedy Algorithm prioritizes computational efficiency, while the Gale-Shapley algorithm focuses on stability, and the Score-Based AllocationMethod allows flexibility in balancing multiple criteria. Our findings reveal that while the Stable Matching Algorithm ensures stable matches, the Score-Based Method optimizes for overall satisfaction based on different objectives, offering valuable insights into the trade-offs involved in choosing each approach.
Effect of Nitrogen and Boron Fertilization on Yield and Quality of Mustard (Brassica juncea) in Chitrakoot Area, Madhya Pradesh, India
Authors: Mishra Ashutosh , Sirothia Pawan , Waladi Bharti , Singh Opendra Kumar
Published: November 2024

A field experiment was conducted in year 2022 in Rabi season at Rajaula Agriculture farm, Mahatma Gandhi Chitrakoot Gramoday Vishwavidyalaya Chitrakoot, Satna (M.P.). Experiment was laid out in randomized block design with thirteen treatment combinations, varying levels of nano-urea and boron application, alongside a standard 100 % NPK as per RDF treatment as the control. Results showed significant differences in seed and oil yield across treatments. The highest seed yield of 1523.81 kg/ha was achieved with T12 (½ RDN + two nano-urea sprays + 1.25 kg B), a notable improvement over the control (T0) at 958.73 kg/ha. Oil content ranged from 13.1% to 35.6%, with the highest in T12, which also produced the maximum oil yield of 542.48 kg/ha. The lowest oil content (13.1%) and oil yield (190.47 kg/ha) were observed in T11 (½ RDN + one nano-urea spray + one water spray + 1.25 kg B). Treatments incorporating nano-urea and higher levels of boron showed the most pronounced increases in both oil content and yield, suggesting a synergistic effect of these nutrients on mustard productivity. Statistical analysis confirmed significant improvements in yield and oil quality with combined boron and nano-urea applications, indicating that T12 is the optimal treatment for maximizing mustard production under similar agro-climatic conditions.
Patient and Rheumatologist Perspectives Regarding Challenges to Achieving Optimal Disease Control in Rheumatoid Arthritis
Authors: Owensby Justin K. , Chen Lang , O'Beirne Ronan , Ruderman Eric M. , Harrold Leslie R. , Melnick Joshua A. , Safford Monika M. , Curtis Jeffrey R. , Danila Maria I.
Published: April 2019

Objective

To identify and prioritize patient‐ and rheumatologist‐perceived barriers to achieving disease control.

Methods

Patients with rheumatoid arthritis (RA) and rheumatologists from the Corrona registry were invited by e‐mail to participate in nominal groups. Two separate lists of barriers were created, 1 from RA patient–only nominal groups and the other from rheumatologist‐only nominal groups, and barriers were sorted into themes. Next, using an online survey, a random sample of RA patients from the Corrona registry were asked to rank their top 3 barriers to achieving disease control.

Results

Four nominal groups totaling 37 RA patients identified patient barriers to achieving control of RA activity that were classified into 17 themes. Three nominal groups totaling 25 rheumatologists identified barriers that were classified into 11 themes. The financial aspects of RA care ranked first for both types of nominal groups, while medication risk aversion ranked second among the perceived barriers of the physician nominal group and third among those of the RA patient nominal group. Among the 450 RA patients surveyed, 77% considered RA a top health priority, and 51% reported being aware of the treat‐to‐target strategy for RA care; the 3 most important patient‐perceived challenges to achieving disease control were RA prognosis uncertainty, medication risk aversion, and the financial/administrative burden associated with RA care.

Conclusion

There are common, potentially modifiable, patient‐ and rheumatologist‐reported barriers to achieving RA disease control, including perceived medication risk aversion, suboptimal treatment adherence, and suboptimal patient–physician communication regarding the benefits of tight control of disease activity in RA. Addressing these obstacles may improve adherence to goal‐directed RA care.