bluuebunny/crossref_metadata_2025 huggingface dataset:
Assessment of cerebrovascular insufficiency with MR-ASL perfusion in patients with moyamoya angiopathy
Authors: Shulgina A. A. , Lukshin V. A. , Shults E. I. , Batalov A. I. , Pronin I. N. , Usachev D. Yu.
Published: May 2021

Purpose. To develop a methodology for assessing the degree of cerebrovascular insufficiency in patients with moyamoya angiopathy (AMM) based on measurement of cerebral blood flow (CBF) and determination the presence of arterial transit artifact (ATA) using MR method of arterial spin labeling (ASL).

Materials and methods. The study included 47 patients with AMM who underwent 148 MR studies in PCASL mode (296 hemispheres), of which 47 (94 hemispheres) were done before surgical treatment. On received perfusion maps 7 areas of interest (ROI) were manually set in the gray and white matter of the brain using “Fusion” technique outside the ATA zones. The CBF values at the central point of the ATA were estimated. In the preoperative stage, 47 patients underwent direct angiography to assess the stage of the disease according to Suzuki, the presence and severity of leptomeningeal and transdural collaterals and MR angiography to assess the stage of the disease according to Houkin and the level of ICA stenosis. Statistical processing included univariate analysis of variance (ANOVA) and chi-square test (IBM SPSS Statistics 23).

Results. ATA was detected in 77% of studies (69% of hemispheres). The average minimum CBF in ATA was 120.2 ± 21.1 ml/min/ 100 g at the lower bound of the confidence interval of 117.43 ml/min / 100 g. The average maximum CBF in ATA was 234.9. Depending on the CBF values in the MCA territory and the presence of ATA, 4 degrees of perfusion deficiency were identified: degree 0 (CBF = 64.5 ± 16.2 ml/min / 100 g, without ATA) corresponded to the stage of “compensation” of cerebral blood flow, degree 1 (CBF = 61.5 ± 16.6 ml/min/ 100 g, with ATA) – “subcompensation”, degree 2 (CBF = 26.5 ± 7.2 ml/min/100 g, with ATA) – “initial decompensation”, degree 3 (CBF = 16.0 ± 4.7 ml/min / 100 g, without ATA) – “decompensation”. The highlighted degrees statistically significantly differed among themselves in all ROIs (p < 0.0001). More severe perfusion deficiency corresponded to the more developed stages of AMM according to Suzuki and Houkin, proximal stenosis of the ICA (p < 0.0001), and more severe neurological deficit (p < 0.02). The occurrence of ATA reliably reflected the presence of leptomeningeal collaterals (p < 0.001).

Conclusions. The proposed method for assessing patterns of ASL perfusion has a good agreement with the stage of the disease, the presence of sources of collateral circulation, the severity of neurological deficit and can be used to assess cerebrovascular insufficiency in patients with AMM.
Dual tracer hybrid radionuclide imaging of a metastatic gastrointestinal neuroendocrine tumor with unknown primary site using 18F-FDG PET/CT and 99mTc-HYNIC-TOC SPECT/CT (case report and literature review)
Authors: Leontyev A. V. , Rubtsova N. A. , Khalimon A. I. , Antonevskaya T. L. , Kuliev M. T. , Levshakova A. V. , Pylova I. V. , Lazutina T. N. , Kaprin A. D.
Published: May 2021

Neuroendocrine tumors (NEТ) are a heterogeneous group of neoplasms of various locations originating from the APUD system cells with biologically active properties. Although immunohistochemical assay for Ki-67 has been proved to have prognostic significance in GEP-NENs, pitfalls may lead to misjudgment of the tumor grades, prognosis and during treatment planning due to the presence of cells with varying degrees of differentiation and proliferative activity within a single lesion, as well as the entire neoplastic process. These features can affect the results of imaging and therapy planning.

An increase in the number of somatostatin receptors on the surface of membrane cells, as well as an increase in glycolysis may occur in NETs. These phenomena play role when choosing imaging methods, as well as in treatment planning.

Combined dual-tracer imaging, specifically PET/CT or SPECT/CT using labeled somatostatin analogues can be used in intermediate assessment of cellular heterogeneity in the entire neoplastic process in NENs and help to minimize diagnostic pitfalls listed above.

We present an observation of a patient with metastatic GEP-NEN of unknown primary in which 18F-FDG PET/CT and 99mTc-HYNIC-TOC SPECT/CT were performed for initial staging. In the framework of this, aspects of use of dual-tracer radionuclide imaging in patients with NENs are widely discussed.
Computed tomography as a method of substantiating a minimally invasive approach in the treatment of esophageal injuries and their complications
Authors: Barmina T. G. , Danielyan S. N. , Kokov L. S. , Sharifullin F. A.-K. , Zabavskaya O. A. , Popova I. E. , Rabadanov K. M. , Gasanov M. A.
Published: May 2021

The purpose of the study. To analyze possibilities of computed tomography (CT) for esophageal injuries and their complications as part of a differentiated approach to the choice of a minimally invasive treatment method.

Materials and methods. The results of CT scans were analyzed in 25 patients with esophageal injuries of various etiologies who were treated at the N.V. Sklifosovsky Research Institute of SP in the period 2019–2020. CT was performed with oral and intravenous bolus contrast, primarily at admission and in dynamics, a total of 77 studies.

Results. In all cases, direct and indirect CT signs of esophageal damage were detected, and the degree of involvement of surrounding organs and tissues in the pathological process was assessed. Based on the data obtained, the following variants of esophageal damage and its complications were identified: intramural esophageal hematoma (2); rupture of the thoracic esophagus without the development of purulent complications (2); rupture of the thoracic esophagus complicated by the development of mediastinitis (4); rupture of the thoracic esophagus with the development of mediastinitis and pleural empyema (13); rupture of the cervical calving of the esophagus, complicated by phlegmon of the neck and descending mediastinitis (4). Different patient management tactics were used for each variant. Thus, the selection and sequence of minimally invasive interventions, such as thoracoscopic sanitation mediastinal and pleural cavity, esophageal stenting, percutaneous endoscopic gastrostomy (CEG) and endoscopic vacuum aspiration system (E-VAS), were carried out taking into account CT data, including observations in dynamics.

Conclusion. CT scan for esophageal injuries allows you to get complete information about both the nature of esophageal damage and its complications, to determine their type, localization and volume. CT data allow us to justify a minimally invasive approach in the treatment of esophageal injuries, to determine the order of interventions. CT studies performed in dynamics allow us to evaluate the effectiveness of treatment and to carry out timely correction of tactics.
РОМАН Л.М. ЛЕОНОВА «СКУТАРЕВСКИЙ» В ИСТОРИКО-ФИЛОСОФСКОМ КОНТЕКСТЕ
И ЕГО ИНТЕРПРЕТАЦИ
Authors: Воробьев А.А.
Published: May 2021

В статье представлена религиозно-философская интерпретация романа
Л.М. Леонова «Скутаревский». Автор предваряет интерпретацию введением в избранную литературно-критическую историографию 1930-х гг., в
которой показывает специфику как советского, так и эмигрантского взглядов на книгу. Особое внимание уделено историко-философскому контексту: представлены оценки романа в трудах Л.С. Выготского, Г.П. Федотова,
П.А. Флоренского. На основании вышеозначенных оценок предпринята попытка рассмотрения «Скутаревского» под принципиально новым углом. Автором предлагается точка зрения, согласно которой одной из ведущих линий
в романе, не отрицающей иных перво – и второстепенных сюжетно-смысловых линий, является художественно-философское осмысление проблемы
рукотворного научно-технического «чуда». По мнению автора, философская
проза Л.М. Леонова может существенно расширить горизонты осмысления
«советского проекта» и русской религиозно-философской мысли XX в.
Ключевые слова: Л.М. Леонов, «Скутаревский», философская проза, литературная критика, русская философия, утопия
Integrating Elements of Modern Technology into Maritime Safety
Authors: Rana P , Majumder PD
Published: May 2021

A majority of the accidents on board a ship occurs due to poor knowledge of safety regulations or carelessness towards the same. As a remedy, this paper will propose ideas that include digitalization of safety procedures so as to realize the powers of visual perception of information over a paper-based one, a unique Safety Wear and Equipment Identification system and pre-board training using Virtual Reality. Interactive, touch-screen monitors, the size of usual tablets will be affixed to the walls of numerous rooms and spaces across the ship (e.g.: engine room) that will revolutionize the way safety norms are implemented. They will also have cameras, affixed. Object-recognition software, paired with these cameras will scan the image of the person, starting a task, to ensure that he/she has every necessary safety wear/equipment/tool on them, specific to the task that they are performing. Unless verified by the software, a person cannot start the job. There’s a study of how this software helps to fulfil International Safety Management (ISM) CODE to a new level and how using it can help shipping companies.
The Collaborative Autonomous Shipping Experiment (CASE): Motivations, Theory, Infrastructure, and Experimental Challenges
Authors: Haseltalab A , Garofano V , Afzal MR
Published: May 2021

The future autonomous ships will be operating in an environment where different autonomous and nonautonomous vessels with different characteristics exist. These vessels are owned by different parties and each uses its owned unique approaches for guidance and navigation. The Collaborative Autonomous Shipping Experiment(CASE) aims at emulating such an environment and also stimulating the move of automatic ship control algorithms towards practice by bringing together different institutes researching on autonomous vessels under an umbrella to experiment with collective sailing in inland waterways. In this paper, the experiments of CASE 2020 are explained, the characteristics of different participating vessels are discussed and some of the control and perception algorithms that are planned to be used at CASE 2020 are presented. CASE 2020 will be held in parallel to iSCSS 2020 at Delft University of Technology, the Netherlands.
Prospects for the development of the timber industry in the context of foreign economic cooperation of the Far East with the countries of North-East Asia
Authors: Shum Nikita Maksimovich
Published: May 2021

In this article, the author describes the far Eastern Federal district as one of the subjects, considers the socio-economic development of the Far East, especially the timber industry. Since this industry is a priority of socio-economic development. The author also describes the problems of development of the timber industry in the Far East, focusing on the production potential, the object of attention also includes customs duties, the cost of forest products. The author considers solutions to problems through the development of foreign economic cooperation with the countries of the Northeast Asia, namely through foreign investment in the timber industry, construction of common enterprises on mutually beneficial terms, etc.
The existence of the narrative about the "petrified woman" and the "sacrilegious dancer" on the territory of Belarus and its borders
Authors: Butov Illia Stanislavovich
Published: May 2021

Information is given about the narratives about the "petrified woman" and the "sacrilegious dancer" that have firmly penetrated into modern religious reality. The story under consideration in a more or less developed form first appears as a rumor in the late 1880s of the IXX century, then reappears in 1895-1896, 1919, and is updated with a new force in the late 1950s in connection with a resonant story from the Kuibyshev region about Zoya's standing (Stone Zoya). Oral and written forms of this new Christian legend were introduced to the territory of Belarus for the second time in the late 1950s with letters of happiness and apocryphal texts about "Zoya's Life". Distinctive features of local texts about a woman turned to stone are given, Parallels are drawn with traditional views of Belarusians on punishment for work on a holiday and the biblical story about Lot's wife. It is emphasized that due to geographical remoteness, the connection of the narrative under consideration with the "original" story of Zoya's standing, not to mention the predecessor texts, has undergone significant reduction, and the miracle itself has practically lost its specific localization here.
A person through the centrist metric of a central worldview: pros and cons
Authors: Sarkarova Naila Akhedovna
Published: May 2021

The article describes the main centrist matrix of the study of man: cosmocentrism, theocentrism, anthropocentrism, ratiocentrism, sociocentrism. Their strengths and weaknesses, as well as the limits of applicability, are analyzed. Some ways of overcoming centrist thinking, which is an exclusive, divisive strategy in culture and thinking, are explored. The article substantiates the importance of an inclusive, connective strategy in culture and anthropology, which allows us to find new dimensions of human essence.
Optimization of management processes in the electric power industry based on mathematical modeling
Authors: Dmitriev Nikolay Dmitrievich , Rodionov Dmitriy Grigoryevich , Zhiltsov Sergey Alekseevich
Published: May 2021

The paper deals with the problems in the electric power industry, do not allow us to ensure a sufficient level of competitiveness of the industry and each individual subject of the electric power industry, the threatens national security, in particular, the economic security of the state, and creates barriers to maintaining the sustainable development of territories. It is proposed to use the economic and mathematical modeling allowed us to determine the high importance of human resources in the final results of the electric power company, which makes it possible to consider the optimization of investment funds from the position of strengthening the focus of management processes in the field of personnel development.
Current trends in small business development in the Republic of Kalmykia (based on the results of an expert survey)
Authors: Kovanova Ekaterina Sergeevna , Badmaeva Nogan Viacheslavovna
Published: May 2021

The article examines the issues of modern trends in the development of small business in the Republic of Kalmykia. One of these trends is entrepreneurship, which actively uses ethnic, national components in its line of business. The purpose of the article is to study the ethno-economic aspects of modern entrepreneurship in Kalmykia. The main research method is an expert survey. A total of 12 experts were interviewed. The study was conducted in May-June 2020 in Elista. As experts, restaurateurs or owners of national cuisine cafes, ateliers, clothing manufacturers, representatives of the tourism business, manufacturers of souvenir products, owners of souvenir shops, manufacturers of ethnic furniture, etc. Experts note the popularity and demand for ethnic goods, handicrafts in the segment of ethnic fashion, ethnic design. And also services of ethno-tourism, ethno-restaurants, which testifies to the prospects of ethno-business and ethno-entrepreneurship in the republic. Active revival of Buddhism, restoration, development of national culture, natural resources make Kalmykia especially attractive for tourists. However, one of the problems in the development of ethnic entrepreneurship is the fact that there are very few masters of national instruments, masters of making complex souvenirs (leather, wood, metal). An expert survey has shown that the development of ethnic entrepreneurship is an important resource for economic development in Kalmykia.
Innovative activity of departments as a factor in the formation of professional competencies of military university cadets
Authors: Kokorev Anton Vladimirovich , Volkov Mikhail Anatolevich
Published: May 2021

The scientific and technological development of modern society determines the need to monitor the innovative activities of universities, departments, and teaching staff. One of the leading factors influencing the formation of professional competencies of cadets studying at a military University is the innovative activity of departments. According to the authors of the article, the quality of training of future military specialists depends on this. The article reveals the aspects of creating conditions for creative self-development of cadets and their active participation in round tables on scientific and technical topics at the Department of military higher education. It is concluded that the innovative activity of University departments has a great influence on the motivation of cadets to participate in scientific work under the guidance of the teaching staff, and also ensures the development of the intellectual potential of future military specialists.
Structure and content of the training process aimed at increasing the power endurance in the preparatory period
Authors: Konovalov Vladimir Leonidovich , Kishkin Aleksey Ivanovich , Katkanova Irina Nikolaevna
Published: May 2021

An increase in the level of strength endurance can be carried out during the period of a special preparatory stage in the annual cycle of training athletes. The present research proposes a periodization of shooters' sports training with the substantiation of the measures taken to develop such a motor quality as strength endurance. The aim of the research is to organize the training process in a way that the development of the motor quality, strength endurance, enhanced performance in shooting. Young men of 13-15 years old engaged in educational training groups of children's and youth sports school on bullet shooting were selected to participate in the experiment.
Using the capacity method to analyze historical events
Authors: Korablev Yuriy Aleksandrovich , Golovanova Polina Sergeevna , Kostritsa Tatyana Andreevna
Published: May 2021

The use of the capacity method of rare events analysis [1,2] for the historical events analysis is demonstrated using the example of the Russian-Turkish wars. Modeling rare events as events of overflow of a certain capacity, for example, a cup of patience, it turns out to recover from these rare events the resulting function of the difference between incoming and outgoing disturbance flows. For different variants of representing the effect of an event, different functions were obtained, which were given an interesting interpretation, as example the speed of preparation for the next war.
Basic principles and approaches of using the project methodology in teaching speaking to students
Authors: Mustafaeva Edie
Published: May 2021

The article describes and analyzes the basic principles and approaches of using the project methodology in teaching spoken English to students. The analysis has identified the basic provisions of the fundamental principles and approaches on which the process of developing a project methodology for teaching students' conversational speech is based.
Art-techniques in the preparation of a musician-performer
Authors: Polushkin Vladimir Georgievich , Strazhnikova Tatyana Ivanovna
Published: May 2021

The authors of the article consider one of the directions of musical pedagogy - the use of art pedagogy in the process of training a musician-performer. Based on the analysis of the research literature and experience describes the possibility of using psychological reserves of music and performing activities, in particular, reception of musical color modeling of the emotional and figurative content of music, are revealed.
Ensino Médio integrado no IFSULDEMINAS: caminhos e descompassos
Authors: Pereira Heloisa Helena Coutinho , Almeida Luana Costa
Published: May 2021

O artigo objetiva analisar os caminhos e conquistas, desafios e descompassos na busca pela implementação da proposta de ensino médio integrado no IFSULDEMINAS. Para tanto, dentro da perspectiva qualitativa de pesquisa, a investigação teve como principais instrumentos de coleta de dados a análise documental e a entrevista semiestruturada. Documentalmente, utilizamos especialmente os Planos de Desenvolvimento Institucional (2009-2018) e os Projetos Pedagógicos dos Cursos (2012-2017). Nas entrevistas (2016-2017) contemplamos um representante da gestão, condutor das políticas de ensino e quatro coordenadores de curso, indicados por melhor consolidar a proposta de formação integrada.Os dados foram analisados na perspectiva da análise de conteúdo, em que selecionamos as unidades de análise e identificamos seus núcleos de conteúdo para a organização das temáticas analíticas do estudo. Os dados revelam uma tentativa importante de efetivação da formação integral, embora haja certo descompasso entre algumas concepções postas pela literatura, pelos documentos norteadores e anunciadas pelos coordenadores.
O desenvolvimento do interesse da docência no contexto do Programa da Residência Pedagógica em Ciências Biológicas
Authors: Abe Rosa Shizue , Arruda Sérgio de Mello , Lucas Lucken Bueno , Lima Maria Ida
Published: May 2021

Esta pesquisa trata de um estudo sobre a questão do desenvolvimento do interesse pela docência, a partir de um grupo de acadêmicos de Licenciatura em Ciências Biológicas, participantes do Programa Residência Pedagógica. Teve como objetivo investigar o interesse deles pela docência a partir deste Programa que os levou à prática docente. Eles foram entrevistados e suas respostas analisadas a partir do referencial da Análise Textual Discursiva. Fundamentadas no Modelo de Quatro Fases do Desenvolvimento do Interesse, as categorias de análise efetivadas evidenciaram que elementos externos acionadores do despertar do interesse favoreceram à permanência dos licenciandos no Programa, e que sua participação em ações formativas congêneres e anteriores, assim como nas atividades propostas ao longo da Residência Pedagógica, contribuíram para sua permanência na licenciatura, promovendo desenvolvimento individual no âmbito da docência.
Educação do campo e inclusão de alunos com deficiência: percepções e práticas docentes
Authors: Porto Klayton Santana , Duboc Maria José Oliveira , Ribeiro Solange Lucas
Published: May 2021

Este estudo tem como objetivo analisar as práticas docentes desenvolvidas no processo de inclusão de alunos com deficiência, em uma escola do campo de Feira de Santana-BA. Foi realizado um estudo de caso, de natureza qualitativa, cujos dados coletados por meio de entrevistas semiestruturadas, realizadas com três professores, desta escola, que trabalham com alunos com deficiência. Dentre os principais resultados encontrados, destacamos que, apesar dos estudantes com deficiência terem o acesso à escola garantido por lei, a Educação Inclusiva ainda não se efetivou na escola do campo investigada. Os dados evidenciam que é necessário um maior investimento por parte da esfera pública, tanto no que se refere à infraestrutura da escola, a formação de professores, como a acessibilidade, em suas várias dimensões.
CIE 244:2021 Characterization of Imaging Luminance Measurement Devices (ILMDs)
Authors:   CIE TC 2-59
Published: May 2021

This document describes the elements, function and characterization of imaging luminance measuring devices (ILMDs). Furthermore, the calibration of ILMDs is described and some guidelines for their use are provided.-\n--\n-Using ILMDs the projection of the luminance distribution of a scene can be recorded and made available for further evaluation. In addition to a simple documentation of measurements, the geometrical assignment of the image points into the object coordinate system often allows more complex calculations by combining luminance, directional and, if necessary, solid angle information (e.g. for glare evaluation). In addition to the flexible evaluation option, it is possible to acquire a large number of measured values quickly and, if necessary, even synchronously. Furthermore, the type of evaluation can also be coupled to the image content, i.e. the image areas to be evaluated can be determined in the image either by their position within the image or by their luminance value. Keywords: Imaging Luminance Measurement Device, ILMD, photometry, luminance distribution
Social composition of first district Zemstvo assemblies of Tauride province (1866–1869)
Authors:   Taurida Academy (structural unit) of the Federal State Autonomous Educational Institution of Higher Education «V. I. Vernadsky Crimean Federal University», Morgunov K. G.
Published: May 2021

The article deals with the question of the social composition of the Zemstvo bodies of the Tauride province during their formation. The first elections to County Zemstvo assemblies are investigated and the influence of the property qualification principle on the electoral process and the formation of Zemstvo bodies is reflected the regional specifics of the districts of the Tauride province and its significance in the social representation of Zemstvo vowels are shown. In conclusion, information is provided on the percentage of social classes in the Zemstvo bodies for the three electoral Curia and the dominant role of the nobles in the assemblies of the first three years
First experience of participation in post-Soviet parliamentary elections in Nizhny Novgorod region: pages of political history
Authors:   Lobachevsky State University, Zanozina Ya. S. , Plitkina V. M. ,   Lobachevsky State University, Fomenkov A. A. ,   Lobachevsky State University
Published: May 2021

The article is devoted to an important event in the political history of post-Soviet Russia, namely the first parliamentary elections in its history. The aim of the work was to determine the specifics of the results of the first elections of deputies of the Russian Parliament after the collapse of the USSR in the Nizhny Novgorod region. The tasks of the work are related to the study of the elections of deputies of the State Duma (both by single-mandate districts and by party lists), and the Federation Council. A number of conclusions are drawn regarding the political sympathies of residents of different administrative-territorial units of the Nizhny Novgorod region in the first half of the last decade. A kind of Nizhny Novgorod «red belt» is defined geographically, consisting of the southern districts of the region, as well as several districts of the north and east of the region, where voters mostly supported the left. It is revealed that the level of political activity in the elections is quite high, which is not surprising in view of the intense political life during the perestroika period in Gorky, and then in Nizhny Novgorod
The autonomy of metaphysics: ontology of Kantian tradition in works of analytical philosophers
Authors:   Tomsk State University, Menshikova A. A.
Published: May 2021

The article presents a critical analysis of the influence of I. Kant's ideas on the work of analytical philosophers. It is substantiated the thesis on the independence of Kantian ontology from transcendental epistemology. The article investigated possible areas of integration for various aspects of Kantian ontology and epistemology in the theories of a number of analytical philosophers (P. F. Strawson, W. V. O. Quine), who were directly influenced by I. Kant's ideas. A semantic analysis of the concepts they use does not confirm the hypothesis about the evolutionary influence of Kantian transcendental epistemology on the ontological aspects of the works of analytical philosophers (ontology of language, logical-semantic concepts, notions of proposition and modality, categories of particulars and universals)
Marcadores de estresse oxidativo e dano muscular em pacientes com DPOC submetidos a um programa de reabilitação pulmonar
Authors: Wu Shaumin Vasconcelos , Dias Amanda Caroline Lobato , Silva Dayane Cereja Ferreira da , Santos Ingrid Ferreira , Santos William Wallace Cordeiro dos , Silva Renata Cunha , Silva Pedro Iuri Castro da , Freitas Jofre Jacob da Silva , Falcão Luiz Fábio Magno , Normando Valéria Marques Ferreira
Published: May 2021

Objetivo: Este artigo buscou analisar o comportamento do estresse oxidativo e a expressão sérica da creatina quinase em portadores de doença pulmonar obstrutiva crônica participantes de um programa de reabilitação pulmonar. Métodos: Trata-se de um ensaio clínico analítico, longitudinal, prospectivo e quantitativo, aprovado pelo comitê de ética em pesquisa com seres humanos (nº 1.965.332). Seis voluntários, com média de idade 67,8, realizaram a espirometria e a análise sanguínea para leitura da creatina quinase e do estresse oxidativo, antes da 1ª sessão (T0) e após a 20ª sessão (T20) do protocolo de Reabilitação Pulmonar. Utilizou-se o teste análise de variância (ANOVA) para comparar as médias entre os dois momentos de testagem por meio do software BioEstat 5.0 com p≤0,05. Resultados: Houve resposta significativa dos marcadores de proteólise muscular por meio da quantificação da creatina quinase isoenzima MB (CK-MB; p=0.026) e creatina quinase total (CK-NAC; p= 0.017) e não significativa para a análise bioquímica do estresse oxidativo (Catalase; p= 0.764) e (Peroxidase lipídica; p=0.584) ao comparar os tempos T0 e T20. Conclusão: Ocorreu um impacto positivo sob a expressão sérica da creatina quinase em portadores de doença pulmonar obstrutiva crônica durante a condução de um protocolo de reabilitação pulmonar.
A Balatonlelle-Rádpusztai Árpád-kori telep
Authors: Molnár István , Sipos Carmen
Published: May 2021

The article summarizes the results of the excava-tions of the Arpad-aged settlement from the 11th–14th century in Balatonlelle-Rádpuszta. We found a pit-house and several outdoor-furnaces with abundant finds: potteries, a spur and a mammut-tooth.
Erődített középkori kolostorok és templomok kutatása Somogy megyében
Authors: M. Aradi Csilla
Published: May 2021

The paper deals with the various causes of fortifi-cation of churches and monastic establishments in Somogy county throughout the Middle ages.
A székesfehérvári Szűz Mária prépostság egykori boltozatai
Authors: Szőke Balázs
Published: May 2021

The Provostry and Church of the Virgin Mary (Szűz Mária) at Székesfehérvár went through several reconstructions in the Middle ages. The last significant expansion was initiated by Matthias Corvinus. The late Gothic elements of the Provostry’s vault was found by Imre Henszlmann in the territory of the ruined monument in the 1860’s. The rib vault dating back to the period of Matthias Corvinus was annexed to the buttress built in the angevin era. The construction with internal buttresses could come into existence as a consequence of this fixity in the building technique. examples for this can be found in the Franciscan Church in Szeged-alsóváros, and in several churches in Transylvania.
Szigetvár az 1566. évi török hadjárat idején. A vár és a város történeti és régészeti kutatásai
Authors: Hancz Erika
Published: May 2021

Using the written and archaeological sources, my aim is to give a statement of the facts about Szigetvár during the last campaign of Süleyman the Magnificent in 1566. The major part of the examination was done with the help of the chronicles, mainly the so called Sigetvar-nâmes, the separate Ottoman chronicles about the campaign and the results of the earlier and new archaeological excavations.
A középkori talajvíz-szint változására utaló jelek a balatonlelle-rádpusztai Árpád-kori telepen
Authors: Molnár István , Sipos Carmen
Published: May 2021

In this study, we demonstrate the results of rise in the groundwater level through the exploration of a settlement dating back to the era of the arpad Dynasty.
A najádok (Bivalvia: Unionidae) elterjedésének vizsgálata a Balaton-vízgyűjtő déli oldalán
Authors: Eck-Varanka Bettina , Kováts Nóra , Benkő-Kiss Árpád , Horváth Eszter , Ferincz Árpád , Paulovits Gábor
Published: May 2021

The unionid mussel fauna of the complex system of waterflows, situated on the southern part of the Balaton-catchment was studied. Altogether thirty-seven sampling points on nine watercourses were sampled in order to de-scribe the mussel assemblages of these waters and to as-sess the actual distribution and abundance of chinese pond mussel (Sinanodonta woodiana) populations. Mussels were found in 46% of the localities, in six out of the nine sampled watercourses. Five native and one non-indigenous unionid mussel species were identified during the sampling campaign. The non-indigenous chinese pond mussel was the most fre-quent species, occurred in 13 sampling sites and its relative abundance was 15.5% in the whole sample. our study also revealed that fishponds are potential sources of the invasive S. woodiana in the Balaton-catchment.
Balaton környéki biotópokból (Tihany, Külső-Somogy) származó Granaria frumentum (Draparnaud, 1801) héjmorfológiájának klímafüggése (Gastropoda: Chondrinidae)
Authors: Domokos Tamás , Sólymos Péter , Kovács Csongorné
Published: May 2021

We present morphometric results for eight popu-lations (680 specimens) collected fom diffrent Granaria fru-mentum habitats from Tihany and Külső-Somogy. Macrocli-matic features of different sampling areas are unchanged, but in spite of the fact we found differences in some instances between size characteristics and distribution curves of the sampled populations. By our opinion these deviatons were genereted by microclimatic differences of the different habi-tats. Therefore morhometry based climate reconstruction re-quires more research and validation.
A Kaposvári Egyetem parkjának állatvilága
Authors: Kovács-Hajdu Katalin , Nagyapáti Nikolett , Bende Zsolt , Lengyel Gábor , Sovány Krisztina , Görföl Tamás , Valovics Szilvia , Lanszki József
Published: May 2021

We summarised faunistic observations carried out in the park of university of Kaposvár (Kaposvár-toponár, so-mogy county) from the last cca. 15 years. the urban green areas, like the park of our university, are important for many conservation reliant animal species. these green areas pro-vide these species some ecologic services for example: feed-ing, resting (migrating birds), reproduction and habitats. the checklist of fauna of the university park is based on occa-sional research performed mainly by students. this record in-cludes 177 invertebrate species (of which 19 are protected), 4 amphibians and 5 reptiles (all protected), 100 birds (of which 9 are strictly protected; 52 nesting species), 31 mammals (of which 15 are protected). most part of the species detected by us (including common species), are published for the first time in connection with the area studied (Kaposvár-toponár). numerous taxa (e.g. near all taxa from invertebrates) are less well explored therefore we encourage further research of the fauna of this university park.
Endoscopic semiotics of metastatic bronchial tumors
Authors: Kontsevaya Anna Y. , Krylovetskaia Mariia A. , Malikhova Olga A. , Komarov Igor G.
Published: May 2021

Aim. To study the possibilities of bronchoscopy in the detection and evaluation of metastatic lung tumors.
Materials and methods. From 2017 to September 2020, 3719 bronchoscopies, including 1081 biopsies during bronchoscopy were performed at the Blokhin National Medical Research Center of Oncology. According to the results of the morphological verification, 40 patients had been diagnosed with lung metastasis.
Results. Endobronchial metastatic tumors from extrapulmonary malignancies are quite rare. After had studying 40 cases of metastatic bronchial tumors, we found that the most commonly primary malignancies associated with endobronchial metastases were breast cancer (12 patients), colorectal cancer (6 patients) and thyroid cancer (4 patients). All patients who had been diagnosed with the pathology during the bronchoscopy had been required to make a biopsy for the purpose of morphological verification.
Conclusion. The value of bronchoscopy lies in the possibility not only of the detailed visual studying and detecting the tumor pathology of the bronchial tree, but also of obtaining material for morphological analysis. In this regard, the role of biopsy during bronchoscopy is extremely important. In the visual signs of tumor lesion, it is necessary to take multiple biopsies from different parts of the tumor.
Sarcopenia, sarcopenic obesity, myosteatosis as factors of poor prognosis in gastrointestinal tract tumors: review
Authors: Dikova Tatyana S. , Zatsepina Alina Y. , Fedorinov Denis S. , Lyadov Vladimir K.
Published: May 2021

Over the past decade, there has been a noticeable increase in the number of publications devoted to the analysis of body composition in the treatment of gastrointestinal malignancies. Sarcopenia (skeletal muscle depletion), sarcopenic obesity and myosteatosis are shown to have a negative impact on the results of surgical and chemotherapeutic treatment of patients with gastrointestinal tumors. The review presents in detail data on clinical value of sarcopenia, sarcopenic obesity and myosteatosis along with methodological aspects of body composition analysis. Different cut-offs and diagnostic criteria exist between Western and Eastern patient populations which makes any comparison or meta-analysis not possible right now. The review presents data from Russian and foreign studies on the influence of body composition on postoperative outcomes and survival in patients with gastrointestinal tumors. The article also discusses the influence of body composition on dose-limiting toxicity of chemotherapy. We aimed at raising awareness of clinicians regarding the high prevalence of cancer cachexia and, precisely, sarcopenia, sarcopenic obesity and myosteatosis in patients with GI tract tumors. Deeper understanding of these syndromes is the key to developing measures for prevention as well as correcting the treatment of patients with gastrointestinal tumors.
Treatment of metastatic hepatocellular carcinoma with lenvatinib. Case report and literature review
Authors: Menshikov Konstantin V. , Sultanbaev Aleksandr V. , Akhmetgareeva Kamila T. , Lipatov Danila O.
Published: May 2021

Hepatocellular carcinoma (HCC) or liver cancer is the most common primary malignant tumor of the liver, which is characterized on the first place by a poor prognosis. HCC was diagnosed in 92 patients (62.6%) in 2019 and the period from January to April 2020 in the Republic of Bashkortostan, and among them, 68.47% had stage IV cancer. International professional guidelines suggest screening for early HCC detection. Systemic drug therapy is the treatment of choice for inoperable HCC according to professional guidelines. Inhibition of the VEGF pathway is one of the current methods of therapy for advanced HCC. Lenvatinib is a tyrosine kinase inhibitor for the treatment of advanced HCC that is not subject to local interventions. This article provides a description of a clinical case of successful treatment of a 67-year-old patient with advanced hepatocellular carcinoma. He was appointed for targeted therapy with lenvatinib for HCC that was not subject to local interventions, which led to long-term stabilization. There was a positive trend in the patients condition from the first weeks of therapy. The working capacity was restored. The therapy showed a satisfactory tolerability profile.
Introduction
Authors: Dobkin Patricia
Published: May 2021

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love letter to my patients
Authors: Gonsalves Carol
Published: May 2021

N/A
Comparative study of atenolol in human plasma by high performance liquid chromatography and capillary zone electrophoresis
Authors: Keerthana G  , Afroz Patan  , Ramachandran S  , Binoy Varghese Cheriyan  , Vijey Aanandhi M
Published: May 2021

Atenolol is a beta-blocker that is cardioselective, meaning it only affects beta receptors. It is used to treat angina pectoris and high blood pressure. The HPLC and Capillary Zone Electrophoresis analytical technique was developed for the purpose of detecting and quantifying Atenolol in human plasma, according to the study paper you're reading right now. The internal standard and atenolol were recovered from the solution after being extracted from plasma using the Liquid-Liquid Extraction method. A mobile phase of 10mM sodium hydrogen phosphate, 7.3mM Sodium Lauryl sulphate (pH=3), methanol, and acetonitrile (40:57:3, v:v:v) is used, with a flow rate of 1.0ml/min. A fluorescence detector was used to detect the isolated materials, which had an excitation wavelength of 229 nm and an emission wavelength of 298 nm. With this in view, Atenolol's and the internal norm's survival times are observed to be 5.4 and 8.3 minutes, respectively. The linear correlation coefficient (R20.9992) was found in the Atenolol calibration curve. The recovery rate for atenolol and an internal norm was estimated to be between 76 and 87 percent. Solid-phase extraction was performed on an uncoated silica capillary with a diameter of 58.5 cm 75 m, and detection was performed at 194 nm in the Capillary Zone Electrophoresis procedure. For an electrolyte solution containing 50mM H3BO3 and 50mM Na2B4O7 (50:50 V/V), atenolol was determined to be present in the solution in less than 3 minutes. Energized with a voltage of 25kV and injected with a hydrodynamic configuration for 4S. Under various conditions, this method was used to assess the stability and capability of measuring Atenolol in human plasma.
Pharmacotherapy of upper gastrointestinal bleeding along with its utility at tertiary care hospital
Authors: Surakanti Bhavani  , Racha Snigdha  , Malreddy Bhavani  , Surakanti Sushma Reddy  , Shravan Kumar P  , Vasudha Bakshi  , Narender Boggula  , Rajeev Kumar Gollapalli
Published: May 2021

Acute upper gastrointestinal bleeding (AUGIB) is the most common GI emergency observed with mortality of 6-10% overall. The authors aimed to assess the pharmacotherapy of upper gastrointestinal bleeding along with its drug utility and their performance. A total of 120 patients were enrolled meeting the criteria and observed that the main cause of upper gastrointestinal bleeding was found to be esophageal varices followed by duodenal ulcers.The major contributing factor for UGI bleed was alcohol and smoking. The study revealed that males are predominantly being affected with UGI bleed; probable reasons may be habitual behaviour of the patients. Majority of the population who are affected were associated with comorbidities like hypertension, cirrhosis, jaundice, hepatitis, ulcers and diabetes mellitus. Portal hypertension was the major complication seen among the study population, followed by Jaundice and Ascites.The most common cause of portal hypertension is cirrhosis of liver. As an initial evaluation modality of all our UGI bleed patients were done with UGI endoscopy for both therapeutic and diagnostic purposes. The most commonly prescribed drugs were anti-secretory agents [pantoprazole], mucosal protectants [sucralfate], vasoactive agents [terlipressin], antibiotics [rifampicin, ceftriaxone, metronidazole]. It is observed in the study with high dose of alcohol consumption results into serious complications and increasing mortality and morbidity.  In the modern era of medical management, it would be better to deal with rational drug prescription in association with clinical pharmacologist suggestions during medical rounds by clinician.
Landscape of research, production, and regulation in venoms and antivenoms: a bibliometric analysis
Authors: Di Fabio José Luis , Cortés Castillo María de los Ángeles , Griffiths Elwyn
Published: May 2021

Objective. To assess the productivity and visibility in research, clinical studies, treatment, use and production of antivenoms against poisonous snakes, scorpions and spiders.

Method. Bibliometric analysis of research and other activities. Articles on venoms and antivenoms published between 2000 and 2020 were retrieved from the Scopus database. The records were analyzed by bibliometric indicators including number of documents per year, journals, authors, and citation frequency. VOSviewer® v.1.6.13 was used to construct bibliometric networks for country co-authorships and co-occurrence of terms.

Results. Australia, Brazil, Costa Rica and India were among the six top countries with most documents and were selected for more detailed analysis. Costa Rica was the country with the largest percentage of its publications dedicated to antivenom production and venomics. Only a few papers dealt with the issues of quality, safety, and efficacy of antivenoms or the role of the national regulatory authorities. The use of VOSviewer® allowed visualization through joint publications of networking between countries. Visualization by co-occurrence of terms showed differences in the research carried out.

Conclusions. Working in a collaborative and coordinated manner these four countries could have a major impact on envenoming globally. Attention should be given not only to antivenom production but also to strengthening regulatory oversight of antivenom products.
Pharmaceutical procurement among public sector procurers in CARICOM
Authors: Preston Charles , King Claire , Hinds Maryam , Burnett Francis , Extavour Rian Marie
Published: May 2021

Objective. To examine multiple aspects of the medicines in CARICOM procurement markets, including manufacturer headquarters location, regulatory history, and type (innovator versus generic); the proportion of World Health Organization (WHO) essential medicines; and the most expensive medicines procured.

Method. An analysis of procurement information from selected CARICOM procurers. Four public sector procurement lists were obtained based on public availability or sharing of data from public sector procurers. Analyses were based on parameters available or deduced from these data.

Results. The majority of products come from manufacturers headquartered in North America and Europe (63%–67%). The percentage of medicines procured from generic companies is 60%–87%; and 25%–50% of medicines procured are on the WHO Essential Medicines List. Wide price variations exist in the most expensive medicines purchased.

Conclusions. The analysis identifies vulnerabilities and opportunities in the procurement situation of CARICOM states, particularly related to quality and rational use of medicines. This analysis represents a baseline that governments and other stakeholders can use in the future.
Exploring the Factors Affecting the Purchase Likelihood of e-Tailer Private Labels.
Authors:   , Yerrabapu Yeswanth
Published: May 2021

In today’s extremely competitive retail marketplace environment, developing and managing profitable private label offerings has become significant for most retailing companies. The purpose of this paper is to understand the influence of e-tailer reputation, product manufacturing country favourability, and online consumer rating on the purchase likelihood of e-tailer private labels. We find that product online consumer ratings positively impact the purchase intention of the private labels. E-tailer reputation has shown a positive impact on the future purchase intentions whereas, country favourability’s effect is found at the time of actual purchase of e-tailer private labels. Being the first research to study the impact of country favourability, e-tailer reputation on e-tailer private labels, this paper offers some insights to the e-tailers.
Exploring the Factors Affecting the Purchase Likelihood of e-Tailer Private Labels.
Authors: Yerrabapu Yeswanth
Published: May 2021

In today’s extremely competitive retail marketplace environment, developing and managing profitable private label offerings has become significant for most retailing companies. The purpose of this paper is to understand the influence of e-tailer reputation, product manufacturing country favourability, and online consumer rating on the purchase likelihood of e-tailer private labels. We find that product online consumer ratings positively impact the purchase intention of the private labels. E-tailer reputation has shown a positive impact on the future purchase intentions whereas, country favourability’s effect is found at the time of actual purchase of e-tailer private labels. Being the first research to study the impact of country favourability, e-tailer reputation on e-tailer private labels, this paper offers some insights to the e-tailers.