bluuebunny/crossref_metadata_2025 huggingface dataset:
PONTO DE CULTURA KANHGÁG JÃRE
Authors: Belfort Susana Andréa Inácio , Mendes de Menezes Magali
Published: January 2022

Os povos indígenas brasileiros tem buscado revitalizar suas expressões culturais, mediante o registro em livros, fotografias, peças artísticas ou audiovisuais. A escrita das nossas línguas, a publicação das nossas histórias, a inserção no mundo da literatura e do audiovisual são ferramentas contemporâneas para visibilizar as lutas e a resistências dos povos indígenas. São iniciativas protagonizadas por indígenas, cuja autoria é pouco disseminada e esbarra na limitada difusão junto aos espaços de saber, onde contribuem para a superação da visão preconceituosa e colonizadora predominante em nossa aldeia global. A valorização das culturas indígenas é um movimento de protagonismo indígena. Apresentaremos iniciativas envolvendo anciãos mestres de cultura Kaingáng, artesãos, artistas, arte educadores, jovens, crianças e profissionais indígenas no contexto do Ponto de Cultura Kanhgág Jãre, do Instituto Kaingáng, valorizando nossos saberes em contribuição à implementação da Lei 11.645/2008.
TRANÇADO ENTRE CULTURAS, ENTRE LÍNGUAS
Authors: De Moura Onorio Isaías , Krengre Candido Sueli , Teixeira de Menezes Ana Luisa , Graeff Wernz Maria Cristina
Published: January 2022

Este artigo apresenta reflexões acerca das relações interculturais que podem atravessar a escrita acadêmica em coautoria, considerando o trançado entre culturas, línguas, entre o simbólico e o mitológico, densificado pelo movimento teórico-vivencial. No contexto de uma universidade comunitária (UNISC), de uma universidade pública (Unipampa) e de um grupo de pesquisa (Peabiru: educação ameríndia e interculturalidade UFRGS/UNISC), a relação entre pesquisadores indígenas e não indígenas fez emergir a Metodologia Vãfy, que convida a aproximar o que aparentemente não se junta: o mundo indígena e o não indígena. A narrativa de origem do povo Kaingang, que apresenta as metades clânicas kamé e kairú, inspira um desenho alternativo de produção acadêmica, cadenciado pelo protagonismo indígena que ensina a estar junto, construindo um campo de vivência intercultural que extrapola o espaço da universidade, reverberando nas relações humanas.
SERVIÇO DE PROTEÇÃO AOS ÍNDIOS NA HISTÓRIA DA ESCOLARIZAÇÃO DO POVO KAINGANG (1940-1967)
Authors: Schneider Medeiros Juliana , Bergamaschi Maria Aparecida
Published: January 2022

O presente artigo aborda a escola implementada pelo Serviço de Proteção aos Índios (SPI) junto ao povo Kaingang, no período de 1940 a 1967, visando compreender a atuação da instituição escolar nas comunidades de Nonoai e Guarita (RS). Resulta de uma tese de doutorado e contou com pesquisa documental no arquivo do Museu do Índio (RJ), e com o registro de relatos orais dos kófa, velhos e velhas Kaingang. A análise dos documentos oficiais e a escuta às vozes dos kofá mostram que a escola, planejada pelo SPI com a intenção de “civilizar”, alfabetizar e difundir ensinamentos agrícolas e cívicos para transformar os indígenas em trabalhadores rurais e desenvolver neles um sentimento de nacionalidade não cumpriu totalmente sua finalidade. A escola efetivamente implementada em Nonoai e Guarita neste período foi fruto de disputas e negociações com as comunidades Kaingang, e os dados evidenciam seu alcance limitado diante do que foi inicialmente anunciado pelo SPI. Indícios apontam que foi a partir da década de 1970 que a escola se expandiu em número e em alcance às crianças.
HISTÓRIA DE UMA LIDERANÇA NAS MEMÓRIAS DE ANDILA KAINGÁNG
Authors: Belfort Susana Andréa Inácio , Kaingáng Andila
Published: January 2022

As memórias de Andila Kaingáng sobre pai Manoel Inácio, seu pai e liderança kanhgág entre os anos de 1930 e 1965.
The Impact of Perceived Corporate Social Responsibility on Purchase Intention: Mediating Role of Brand Attitude and Moderating Role of Generation X & Y
Authors: Arachchi H. A. D. M. , Mendis Trevor
Published: January 2022

This study, based on the Theory of Planned Behavior (TPB) and the Generation Cohort Theory, attempts to examine the degree of relationship between Perceived corporate social responsibility and Purchase intention, the mediating role of Brand attitude, and the moderating effect of Generation X and Y on the relationship between Perceived corporate social responsibility and Purchase intention. The study was carried out on quantitative techniques and followed the deductive approach. The data was collected through a structured questionnaire. Stratified Random Sampling was used to gather data, and the final sample consisted of 392 individual consumers. The data was analyzed using the SPSS and Partial Least Squares-Structural Equation Modelling (PLS-SEM) approaches using Smart PLS 3.0. It was found that Perceived corporate social responsibility related significantly to Purchase intention. Moreover, the relationships between Perceived corporate social responsibility and Brand attitude and Brand Attitude and Purchase Intention were significant. Therefore, Brand attitude was found to be a partial mediator and Generation X and Y to be significant moderators of the aforementioned relationship. There were a few limitations in this study which can be examined by future research. One limitation is that the findings of the research was based on one province consisting three districts. Another limitation of this study is that the qualitative and quantitative approaches of this study could have been integrated to yield the mixed method approach through which the findings could have been further clarified, thus enhancing the parameters of the findings. This is the first study empirically investigate of perceived corporate social responsibility on purchase intention: mediating role of brand attitude and moderating role of generation x & y in the Asian context. And also, important for Marketers in Sri Lanka in deciding their marketing strategies catering to different CSR implementation and purchasing patterns in between the genders.
Editorial: Poesía, profetismo y teología
Authors: Rivera Pagán Luis N.
Published: January 2022

La rigurosidad académica del pensar teológico no tiene porque contradecir la sugestividad poética de su discurso ni su desafío profético, como por años han demostrado a la saciedad, desde la teología el brasileño Rubem Alves (Alves, 1992) y desde la poesía el peruano/salmantino Alfredo Pérez Alencart. La poesía recorre los senderos del misterio, y, al así hacerlo, se hermana a la creatividad literaria que muchos, despistados por la rigidez del escolasticismo clásico, consideran su adversaria - la teología.
Planeación transfronteriza y movilidad en la región Matamoros-Brownsville (RMB): ¿de los espacios de flujo a los espacios de lugar?
Authors: De las Fuentes Hernández Arturo José , Peña Sergio
Published: January 2022

El objetivo de este artículo es analizar la planeación transfronteriza enfocada en la movilidad en la región Matamoros-Brownsville (RMB), como un caso de éxito, y a través de este reflexionar sobre los procesos de planeación urbano-transfronteriza que se implementaron. El documento pone a prueba la hipótesis de que la movilidad transfronteriza en la RMB no solamente se enfoca en los espacios de flujo que facilitan los cruces de mercancías y personas, sino también en los espacios de lugar que generan una identidad colectiva y arraigo al lugar. Los dos estudios de caso que se abordan son la relocalización de las vías del ferrocarril y la creación del Centro Cultural Binacional (CeCuBi). El proceso de planeación para el Proyecto Ferroviario se inició en 2001 y entró en operaciones en agosto de 2015, mientras que la segunda fase del proyecto, el CeCuBi, comenzó su etapa de construcción en agosto de 2021.
Del Sumak Kawsay al debate por el Buen Vivir: significados en disputa y disputa por los significantes
Authors: Vásquez Bustamante Juan Pablo , Orellana Yáñez José , Rodrigues Teixeira Juliane
Published: January 2022

El término “Buen Vivir” ha sido planteado como la traducción al castellano del principio filosófico kichwa-amazónico del Sumak Kawsay. A partir de su incorporación en la Constitución de la República del Ecuador en 2008 como modelo de sociedad y horizonte de realidad, se ha generado un intenso debate político y académico entre distintas formas de entender e interpretar este concepto. Este artículo concibe el Buen Vivir como un significante, objeto de una permanente disputa por su significación y apropiación. A través de un análisis documental de fuentes primarias y secundarias, y sobre la base de un trabajo de análisis y síntesis de tres propuestas de tipologías para estos debates, este artículo analiza y reordena el campo de tensión (o discusión) en cuatro corrientes o grupos de discursos que, a partir de sus intereses, perspectivas y marcos paradigmáticos, arguyen sobre la significación y apropiación del ideal del Buen Vivir.
Selectos pero desiguales: inmigrantes latinoamericanos en México (1990-2015)
Authors: Ariza Marina , Jiménez Chaves Luis Felipe
Published: January 2022

Con base en técnicas estadísticas multivariadas, se analiza la heterogeneidad (sociodemográfica y sociolaboral) de la inmigración latinoamericana en México (1990-2015) como parte de los intercambios intrarregionales. Los resultados confirman el predominio femenino y la alta selectividad de los latinoamericanos residentes en México, nacidos fuera de Centroamérica, y su mejor inserción laboral en relación con el resto de los latinoamericanos y los mexicanos. El contraste entre colectivos de mayor y menor tradición migratoria al país (cubanos y argentinos; colombianos y venezolanos) revela patrones demográficos consistentes con dicha diferenciación, e importantes desigualdades internas medidas a través del ingreso laboral, en las que inciden tanto el origen de los inmigrantes como la diversidad de los mercados de trabajo en que participan.
Elettroshock e autonomia di scelta dello psichiatra
Authors: Fenudi L. R. , Marchetti M.
Published: January 2022

Il tema del consenso alla terapia psichiatrica sembra occupare, negli ultimi tempi, una considerevole parte delle riflessioni etico-deontologiche degli studiosi, con l'affermarsi di posizioni decisamente lontane dall'antico patemalismo che pareva connotare la Psichiatria forse più di altri ambiti della Medicina. Ci si interroga, infatti, sul diritto al rifiuto ed alla scelta della terapia da parte del paziente. Del resto le recenti acquisizioni del dibattito scientifico sul consenso del paziente psichiatrico sembrano essere state recepite solo in minima parte al di fuori del contesto culturale dal quale sono emerse. Ad esemplificazione delle difficoltà di concretizzare in normativa i principi etico-deontologici, si è presa in esame la Circolare n. 33/94 dell'Assessorato alla Sanità della Regione Lazio, nella quale sono contenute delle raccomandazioni in tema di terapia elettroconvulsivante (elettroshock o ES). Al di là dell'aspetto formale, emergono dei punti criticabili. Anzitutto l'assimilazione dell'elettroshock all'insulina-shock-terapia; la possibile eccessiva burocratizzazione della raccolta del consenso del paziente; la possibilità che sia riconosciuto valido il consenso prestato da altri (parenti o sanitari del Centro di Igiene Mentale); l'equiparazione acritica di intetventi tanto diversi quali la psicoterapia, la psicofarmacoterapia e l'ES. A conclusione viene ribadito che la migliore tutela della libertà e dignità del paziente, e in particolare di quello psichiatrico, si può ottenere con una forte riaffermazione della responsabilità individuale del medico.
Integrated analyses of density, P-wave velocity, lithogeochemistry, and mineralogy to investigate effects of hydrothermal alteration and metamorphism on seismic reflectivity: a summary of results from the Lalor volcanogenic massive-sulfide deposit, Snow Lake, Manitoba
Authors: Schetselaar E M , Bellefleur G , Hunt P
Published: January 2022

We present herein a summary of integrated data analyses aimed at investigating the effects of hydrothermal alteration on seismic reflectivity in the footwall of the Lalor volcanogenic massive-sulfide (VMS) deposit, Manitoba. Multivariate analyses of seismic rock
properties, lithofacies, and hydrothermal alteration indices show an increase in P-wave velocity for altered volcanic and volcaniclastic lithofacies with respect to their least-altered equivalents. Scanning electron microscopy-energy dispersive X-ray spectrometry analyses of drill-core samples
suggest that this P-wave velocity increase is due to the high abundance of high P-wave velocity aluminous minerals, including cordierite, Fe-Mg amphibole, and garnet, which in volcanic rocks are characteristic of VMS-associated hydrothermal alteration metamorphosed in the amphibolite facies. A
seismic synthetic profile computed from a simple amphibolite-facies mineral assemblage model, consisting of mafic-felsic host rock contacts, a sulfide ore lens, and a discordant hydrothermal conduit, show enhanced seismic reflections at conduit-host rock contacts in comparison to the equivalent
greenschist facies mineral assemblage model. Collectively our results suggest that VMS footwall hydrothermal alteration zones metamorphosed under middle- to upper-amphibolite facies conditions have enhanced potential for seismic detection.
Three-dimensional magnetotelluric modelling of the Lalor volcanogenic massive-sulfide deposit, Manitoba
Authors: Ansari S M , Schetselaar E M , Craven J A
Published: January 2022

Unconstrained magnetotelluric inversion commonly produces insufficient inherent resolution to image ore-system fluid pathways that were structurally thinned during post-emplacement tectonic activity. To improve the resolution in these complex environments, we
synthesized the 3-D magnetotelluric (MT) response for geologically realistic models using a finite-element-based forward-modelling tool with unstructured meshes and applied it to the Lalor volcanogenic massive-sulfide deposit in the Snow Lake mining camp, Manitoba. This new tool is based on mapping
interpolated or simulated resistivity values from wireline logs onto unstructured tetrahedral meshes to reflect, with the help of 3-D models obtained from lithostratigraphic and lithofacies drillhole logs, the complexity of the host-rock geological structure.
The resulting stochastic model provides a more realistic representation of the heterogeneous spatial distribution of the electric resistivity values around the massive, stringer, and disseminated sulfide ore zones. Both models were combined into one seamless tetrahedral mesh of the resistivity
field. To capture the complex resistivity distribution in the geophysical forward model, a finite-element code was developed. Comparative analyses of the forward models with MT data acquired at the Earth's surface show a reasonable agreement that explains the regional variations associated with the
host rock geological structure and detects the local anomalies associated with the MT response of the ore zones.
Organic geochemistry and petrology of sedimentary exhalative Pb-Zn and polymetallic hyper-enriched black shale deposits in the Selwyn Basin, Yukon
Authors: Peter J M , Gadd M G , Jiang C , Reyes J
Published: January 2022

Paleozoic strata of the Selwyn Basin host sedimentary exhalative (SEDEX) Pb-Zn deposits, and age-correlative strata of the Richardson trough host polymetallic hyper-enriched black shale (HEBS) deposits. In both deposit types, organic matter is spatially and
temporally associated with mineralization. We investigated the characteristics of organic matter in mineralization and unmineralized host rocks in the XY Central SEDEX deposit in the Howard's Pass district, and the Nick and Peel River HEBS deposits in the Richardson trough using Rock-Eval pyrolysis,
organic petrography, and solvent extraction and gas chromatography mass spectrometry (GCMS) analysis of the soluble organic matter (SOM). All samples experienced extremely high thermal maturity (Tmax up to 599°C), indicating they contain low SOM. Rock-Eval parameters S1, S2, HI, and OI values
are low. Total organic carbon (TOC) values are low for Nick and Peel River and are generally higher for XY Central. Residual carbon values are universally high. Mineral carbon values are low for deposits studied (one outlier). Pyrobitumen reflectance is mostly below 5.80%. Full-scan GCMS
analyses of SOM reveal that most, if not all, high molecular weight hydrocarbons, including biomarkers, have been lost due to thermal cracking and many detected peaks are likely due to contaminants introduced during sampling.
Geochemical evidence for a magmatic contribution to the metal budget of the Windy Craggy Cu-Co(±Zn) volcanogenic massive-sulfide deposit, northwestern British Columbia
Authors: Leybourne M I , Peter J M , Schmidt M
A , Layton-Matthews D , Voinot A , Mathieu L
Published: January 2022

Volcanogenic massive-sulfide (VMS) deposits may have had metal contributions from magmatic degassing and leaching of footwall rocks. The Windy Craggy Cu-Co-Zn VMS deposit in northwestern British Columbia may include magmatic contributions, based on laser-ablation
inductively coupled plasma mass spectrometry (LA-ICP-MS) of fluid inclusions (enriched in Sb, Sn, and Bi) and lithogeochemistry. Sulfide-mineral trace-element abundances in the massive-sulfide orebody, underlying stockwork zone, gold zone, and altered and unaltered mafic rock and argillite were
analyzed by LA-ICP-MS. Elevated Au, W, As, Bi, Sb, Se, Te, Tl, Ag, Co, and Mo contents occur within the gold and/or stockwork zones. Increasing 'magmatic metals' with increasing Co/Ni values suggest direct magmatic contribution to the deposit. Covariation of Co with these so-called 'magmatic
elements' indicates that it, too, may be of magmatic origin, sourced via fluids exsolved from a crystallizing magma; however, evidence from the composition of rocks and sulfide minerals from Windy Craggy and other VMS deposits suggests that there is probably no meaningful distinction between
hydrothermal leaching and direct magmatic contributions and that most - if not all - fluids that form VMS deposits should be termed 'magmatic-hydrothermal'.
Piperine suppresses growth and migration of human breast cancer cells through attenuation of Rac1 expression
Authors: Buranrat Benjaporn , Junking Mutita
Published: January 2022

Objective:

To investigate the effect of piperine on human breast cancer cells.

Methods:

The effect of piperine on proliferation and migration of human breast cancer cells, MCF-7 and MDA-MB-231, was investigated using colony formation assays, wound healing assays, Matrigel migration assays, flow cytometry, RT-qPCR, and Western blotting assays.

Results:

Piperine inhibited the growth of MCF-7 and MDA-MB-231 cells and suppressed colony formation. Cell reduction at the G0/ G1 phase and cell arrest at the G2/M phase were observed in breast cancer cells. However, the significant effect was only demonstrated in MDA-MB-231 cells. Moreover, cancer cell migration was suppressed by piperine at low concentration. RT-qPCR and Western blotting assays showed that piperine downregulated Rac1 gene and protein expression.

Conclusions:

Piperine could inhibit growth and migration of breast cancer cells by reducing Rac1 gene and protein expression.
Male infertility
Authors: Shah Kirati M. , Gamit Kanan G. , Raval Manan A. , Vyas Niraj Y.
Published: January 2022

Male factor infertility has now become a major health disorder, affecting human reproduction and developing worldwide as a serious medical and social issue. It causes trauma, emotional instability, and mental stress in the affected couples. In nearly half of the analyzed cases, male-associated factors are the major contributors. The present review outlines a wide range of factors responsible for male infertility. We performed an in-depth literature review of the global index of infertility by using data from World Health Organization's website, Elsevier's, PubMed and Scopus databases as well as journals. The quality and quantity of semen, male hormonal imbalance, genetic deterioration, and reactive oxygen species are the fundamental causes of male factor infertility. In addition, air quality, water quality, noise pollution, lifestyle changes, improper diet consumption, malnutrition, exposure to chemicals and toxins, smoking habits, drug abuses, major diseases, and medications are also contributors to infertility issues that can temporarily or permanently influence male reproductive system. We also reviewed the prevalence of male infertility in different countries.
Predictors of vision following ranibizumab injection for age-related macular degeneration
Authors: Sayed Khulood M. , Moussa Elshimaa A. Mateen
Published: January 2022

Purpose

The aim of this study was to investigate the optical coherence tomography (OCT) parameters that can predict the vision of patients with exudative age-related macular degeneration (AMD) 1 month following intravitreal ranibizumab injection.

Patients and methods

This is a prospective consecutive case-series study that was conducted on 20 eyes of 18 consecutive patients who received intravitreal ranibizumab injection for exudative AMD. A spectral-domain OCT imaging was done just before and 1 month following the injection. The main outcome measures were the correlations between the postinjection vision and the preinjection OCT parameters.

Results

A significant reduction was noted in retinal volume at the 3 and 5-mm central circles. The reduction in retinal thickness was statistically significant, while the reduction in other OCT parameters was insignificant. There was a strong correlation between postinjection vision and each of the following: foveal volume at 1 mm, full retinal thickness at the fovea, and retinal pigment epithelium elevation at the fovea (r>0.7, P<0.05). Multivariate analysis showed that the foveal volume (r
2=0.538) was the most important predictor factor for visual acuity, 1 month following ranibizumab injection.

Conclusions

Foveal volume is the most important factor for vision prediction and can be used as an early visual predictor 1 month following ranibizumab injection in patients with AMD.
Septicemia Secondary to Late-Onset Infection After Fracture Fixation
Authors: Renjith K. R. , Sunil P. P. , Jacob Baiju Sam , Vijayan Arvind P.
Published: January 2022

Infection after fracture fixation (IAFF) is one of the most dreadful complications in the treatment of musculoskeletal trauma. Early detection is paramount, and the presentation can be heterogeneous with local as well as systemic features depending on the postoperative duration and microbiological virulence. We describe an unusual presentation of a young adult immunocompetent male with septicemia following late-onset IAFF, where a multidisciplinary approach helped in the early diagnosis and successful treatment.
Medical and Nonmedical Fainting
Authors: Onu Justus Uchenna , Oriji Sunday Onyemaechi , Uwakwe Richard
Published: January 2022

In recent times, the Nigerian public space has been awash with various incidences of “fainting” during investigations seeking to unravel issues surrounding alleged financial mismanagement in public institutions. A critical question is, to what extent do these apparent fainting behaviors represent a true illness-related event? Feigning of medical symptoms for external gains is well-described phenomenon with enormous cost to both forensic and nonforensic settings. Separating the sheep from the goats in these situations is a task many clinicians are not familiar with. This article aims to articulate the current models of malingering and to highlight the various ways of detecting deception in clinical settings. The authors opine that an integrative strategy, which involves the combination of various approaches with emphasis on the verbal and nonverbal signals during clinical interviews coupled with psychological testing and perhaps neuroimaging techniques, may improve the detection of deception in the clinical setting. We recommend that clinicians should not shy away from employing any of these “malingering diagnostic” approaches when there is a reasonable suspicion to the veracity of patients' symptoms such as fainting during a panel inquiry.
Geriatric Pharmacology Case Series: Direct Oral Anticoagulants for Older People With Cancer
Authors: Tsu Laura , Nguyen Christina , Ramos Ronald
Published: January 2022

This case study focuses on the treatment of a patient with cancer-associated venous thromboembolism (VTE). This is a common complication of cancer that can result in substantial morbidity and mortality. The case reviews the approach of analyzing older people with cancer-associated VTE
and its treatment options.
Opicapone: Once-Daily COMT Inhibitor for the Treatment of Wearing Off in Parkinson’s Disease
Authors: Craft Brittany M. , Baker Danial E. , Levien Terri L.
Published: January 2022

Objective To provide a review of opicapone as a treatment for end-of-dose wearing off associated with long-term levodopa therapy in patients with Parkinson’s disease (PD). Data Sources PubMed, Web of Science, and Google Scholar were searched for
relevant literature using the following terms: management, treatment, opicapone, BIA 9-1067, entacapone, and tolcapone. Current guidelines and the manufacturer’s package inserts were also reviewed. Study Selection/Data Extraction Recent literature and published studies
of opicapone in the management of wearing off. Data Synthesis Long-term use of levodopa is associated with known complications of motor fluctuations and dyskinesia. The addition of a drug with fewer daily administrations may reduce the complexity of the current medication
regimen, improve adherence, and reduce the risk of adverse events in older people with PD. The Food and Drug Administration (FDA) approved a new catechol-O-methyltransferase (COMT) inhibitor opicapone in combination with levodopa/carbidopa to treat wearing off in PD patients on April
24, 2020. Conclusion Opicapone offers patients with PD a once-daily option with a favorable side effect profile, increased exposure to levodopa, and reduction in “off” time. It may be an appropriate second line option in patients who are intolerant or do not
respond with entacapone.
The Impact of a Pharmacist-Led Hypertension Medication Management Program on Older People in a Skilled Nursing Facility
Authors: Stone Rachel , Oganesyan Aida , Marco Noachim , Smith Rick , Hoffman Janice
Published: January 2022

Objective To illustrate the impact of a pharmacist-led hypertension medication management program on skilled nursing facility residents. Design Sixteen-week retrospective, observational study. Setting Long-term care, local skilled nursing
facility. Patients, Participants Subjects with a diagnosis of hypertension and treated with at least one antihypertensive medication were identified using electronic health records. The subjects also needed to be enrolled in the Hypertension Medication Management Program,
and were excluded if receiving hospice or psychiatric treatment or had active infection with COVID-19. Initially, 120 residents were eligible with 54 in an intervention and 66 in a control group. At 16-weeks, a total of 67 residents remained after some were lost to follow-up. Interventions
Under a collaborative practice agreement, a pharmacist optimized medications, ordered monitoring of vital signs, and relevant labs in conjunction with standard physician care (intervention): these subjects were compared to those who received standard physician care alone (control).
Results There was a significant difference in the proportion of subjects who attained treatment goals for diastolic BP, but not for systolic BP or mean arterial pressure. The proportion of subjects in the intervention group who had falls, hospitalization or death was not significantly
different between groups. diastolic pressure (90.9% and 38.0%; P < 0.0001; 86.7% and 32.4%; P < 0.0001) but not for systolic and mean arterial pressure at 8 and 16 weeks. For secondary endpoints, there was clinical significance in de-prescribing incidence (P <
0.0001) but not for fall events, hospitalizations, and death. However, control group had 11% more falls and 1.2% more hospitalizations. Conclusion A pharmacist-led hypertension program appeared to impact skilled nursing facility residents by allowing attainment of maintaining
diastolic blood pressure, goals de-prescribing events, and reducing fall incidence and hospitalization. The intervention has the potential to promote de-prescribing but does not appear to have increased the prevalence of serious adverse outcomes relative to standard practice.
On combinatorics of the Arthur trace formula, convex polytopes, and toric varieties
Authors: Asgari Mahdi , Kaveh Kiumars
Published: January 2022

We explicate the combinatorial/geometric ingredients of Arthur’s proof of the convergence and polynomiality, in a truncation parameter, of his noninvariant trace formula. Starting with a fan in a real, finite dimensional, vector space and a collection of functions, one for each cone in the fan, we introduce a combinatorial truncated function with respect to a polytope normal to the fan and prove the analogues of Arthur’s results on the convergence and polynomiality of the integral of this truncated function over the vector space. The convergence statements clarify the important role of certain combinatorial subsets that appear in Arthur’s work and provide a crucial partition that amounts to a so-called nearest face partition. The polynomiality statements can be thought of as far reaching extensions of the Ehrhart polynomial. Our proof of polynomiality relies on the Lawrence–Varchenko conical decomposition and readily implies an extension of the well-known combinatorial lemma of Langlands. The Khovanskii–Pukhlikov virtual polytopes are an important ingredient here. Finally, we give some geometric interpretations of our combinatorial truncation on toric varieties as a measure and a Lefschetz number.
N-colored generalized Frobenius partitions: generalized Kolitsch identities
Authors: Aygin Zafer Selcuk , Nguyen Khoa D.
Published: January 2022

Let
$N\geq 1$
be squarefree with
$(N,6)=1$
. Let
$c\phi _N(n)$
denote the number of N-colored generalized Frobenius partitions of n introduced by Andrews in 1984, and
$P(n)$
denote the number of partitions of n. We prove
$$ \begin{align*}c\phi_N(n)= \sum_{d \mid N} N/d \cdot P\left( \frac{ N}{d^2}n - \frac{N^2-d^2}{24d^2} \right) + b(n),\end{align*} $$
where
$C(z) := (q;q)^N_\infty \sum _{n=1}^{\infty } b(n) q^n$
is a cusp form in
$S_{(N-1)/2} (\Gamma _0(N),\chi _N)$
. This extends and strengthens earlier results of Kolitsch and Chan–Wang–Yan treating the case when N is a prime. As an immediate application, we obtain an asymptotic formula for
$c\phi _N(n)$
in terms of the classical partition function
$P(n)$
.
Comparison of acoustic rhinometry and nasal inspiratory peak flow as objective tools for nasal obstruction assessment in patients with chronic rhinosinusitis
Authors: Proimos Efklidis K. , Kiagiadaki Devora E. , Chimona Theognosia S. , Seferlis Fokion G. , Maroudias Nicolas J. , Papadakis Chariton E.
Published: January 2022

Background: Chronic rhinosinusitis (CRS) is a disease with increasing incidence, characterized by persistent symptoms and negative impact on patient`s quality of life. Nasal inspiratory peak flow (NIPF) and acoustic rhinometry (AR) were studied and compared as assessment tools for CRS with or without nasal polyps (NP), as well as, in follow up monitoring of conservative medical treatment. Objectives: Seventy-eight patients were prospectively studied. Objective assessment included NIPF and AR at baseline and at 4 and 8 weeks after onset medical treatment. Measurements were studied in correlation with Sinonasal Outcome Test-22 (SNOT-22) questionnaire, Visual Analogue Scale (VAS) and endoscopic appearance score (EAS). Results: Both NIPF and AR improved significantly, after medical treatment. NIPF score reflected CRS symptoms` improvement according to SNOT-22 total score at the end of treatment protocol, showing moderate to strong correlation with nasal obstruction VAS grading during the treatment period. AR measures were associated with EAS in all sets of examinations and correlated moderately with VAS scoring at 8 weeks. Conclusion: NIPF and AR were proven to be promising methods for objective evaluation and monitoring of nasal obstruction based on different aspects of nasal physiology in patients with CRS.
Treatment outcomes of midfacial segment pain: experience from the Liverpool multi-disciplinary team facial pain clinic
Authors: Leong Samuel C. , Lazarova Lepa , Tsang Hoo K. , Banhegyi Gyorgy
Published: January 2022

Objectives: Midfacial segment pain (MSP) has the characteristics of tension-type headache which is confined to the midface cor- responding to the second division of the trigeminal nerve. This review presents treatment outcomes of MSP patients managed at the Multi-disciplinary Team (MDT) Facial Pain Clinic in Liverpool. Methodology: Prospective clinical outcome performed in a tertiary referral centre for complex facial pain syndromes. Main outcome measures: Sino-Nasal Outcome Test (SNOT). Clinical "success" was defined as an improvement in total SNOT score of >9 points and a reduction of the ear-facial symptoms sub-domain score by ≥50% from baseline. Results: The average age of the cohort was 49 years, with an average follow-up of 12 months. The overall pre-treatment total SNOT-22 score was 59.5 which improved significantly to 42 at latest follow-up. Although the average scores of all sub-domains improved, only the ear-facial symptoms and psychological issues sub-domains achieved statistical significance. When the criterion for success was applied, nine patients fulfilled this definition at an average of 12 months follow-up. The baseline total SNOT score in this cohort improved from 60.6 to 19.7. Half of these patients achieved success within 18 months of commencing treatment and the probability of attaining success at long-term follow-up was high. Conclusions: Treatment of midfacial segment facial pain is complex and requires follow-up to achieve any meaningful clinical outcome.
Smoking effects on quality of life of allergic rhinitis patients after sublingual immunotherapy
Authors: Katotomichelakis M. , Tripsianis G. , Daniilidi A. , Cassimos D. , Kourousis C. , Vogiatzaki T. , Danielides V.
Published: January 2022

Background: Although tobacco smoking is of great concern, there is no evidence for the effects of smoking on quality of life (QoL) results after sublingual immunotherapy (SLIT). Objective: This study aims tο explore any association between smoking habits (duration and quantity) and QoL results after SLIT in allergic rhinitis (AR). Methodology: One hundred and sixty three patients following SLIT for AR were participated. SLIT efficacy related to smoking was prospectively evaluated by means of validated widely used QoL questionnaires, either for assessing psychology (Zung Anxiety Scale, State-Trait Anxiety Inventory, Zung Depression Scale and Beck Depression Inventory) or generic (Short Form-36) ones, pre- and immediately upon cessation of SLIT. Smoking habits were expressed in pack-years. Results: Significant improvement of total symptoms score (T5SS) and of all QoL questionnaires' results were observed in our patients' group, both for smokers and non smokers. The comparison of changes between smokers and non smokers, controlling for the effect of all patients' characteristics, showed that there was no significant differences on improvement values. Additionally multivariate linear regression analysis revealed that the effect of pack-years on the QoL scales was not significant. Conclusions: Our results suggest that smoking habits (quantity of daily smoking and duration) do not influence the success of SLIT with regards to QoL outcomes.
Hereditary haemorrhagic telangiectasia
Authors: Rimmer Joanne , Lund Valerie J.
Published: January 2022

Background: Hereditary haemorrhagic telangiectasia is an autosomal dominant vascular disease characterized by recurrent epistaxis, mucocutaneous telangiectasia and visceral arteriovenous malformations. Methodology: The genetic basis and pathophysiology of the disease are discussed. Diagnostic criteria and the clinical course of the condition are considered. The current management options, both medical and surgical, are reviewed. Conclusions: Hereditary haemorrhagic telangiectasia requires specialist treatment for the problems it causes, and is best managed in specialist centres. Epistaxis is often the major symptom, significantly affecting patients' quality of life. An understanding of the available treatment options is therefore important for the otorhinolaryngologist.
Reduced effect of intravenous antibiotic treatment on sinonasal markers in pulmonary inflammation
Authors: Doht Franziska , Hentschel Julia , Fischer Nele , Lehmann Thomas , Markert Udo R. , Boer Klas , Pfister Wolfgang , Pletz Mathias W. , Guntinas-Lichius Orlando , Mainz Jochen G.
Published: January 2022

Background: Chronic bacterial rhinosinusitis is a common feature in Cystic fibrosis (CF) as mucociliary clearance in the sinonasal compartment is impaired. Aim of the present prospective study was to compare dynamics of inflammatory markers in the upper and lower airways (UAW/LAW) during systemic antibiotic therapy. Methods: Nasal lavage and sputum of 16 CF-patients receiving an IV-antibiotic treatment against Pseudomonas aeruginosa and/ or Staphylococcus aureus were collected before and during treatment (median after 7.5 days). Cytological changes, DNA concentration, and inflammatory markers interleukin (IL)-4, IL-8, IL-13 and Myeloperoxidase (MPO) were assessed in samples from both airway compartments. Results: Total cell count declined significantly in LAW-samples but not in UAW. Although MPO and IL-8 decreased significantly in both airway compartments, this was considerably more pronounced for LAW (median decrease MPO: LAW=9.8-fold vs UAW=1.75-fold, respectively; IL-8: LAW=3-fold vs UAW=1.9-fold, respectively). Discussion: This is the first publication demonstrating substantially lower effects of IV-antibiotic treatment on sinonasal than on pulmonary inflammatory markers. Consequently, our findings highlight limitations of systemic antibiotic treatment to control infection in the sinonasal compartment. Primarily, we attribute this to the paranasal sinus ́ structure: these hollow organs, which in bacterial sinusitis are frequently filled with pus, mucoeceles and polyps, are not reached effectively by systemic antibiotic treatment.
Hyperbaric oxygen therapy of olfactory dysfunction in diabetic neuropathy with type 2 diabetes mellitus and a new definition Diabetic Olfactopathy
Authors: Veyseller B. , Dogan R. , Yenigun A. , Aksoy F. , Tugrul S. , Dogan E.E. , Ozturan O.
Published: January 2022

Background: Hyperbaric Oxygen therapy is recommended as an adjuvant therapy for diabetic neuropathy. To investigate olfactory dysfunction and show the effectiveness of hyperbaric oxygen treatment in patients with type 2 diabetic neuropathy. Material and methods: Patients diagnosed with Type 2 DM and diabetic neuropathy were included in the group 1. Patients of Group 1 were administered with a hyperbaric oxygen therapy for 30 sessions and patients who returned for a check up following 30 sessions were incorporated into the Group 2. Healthy volunteers with no medical problems were included in the study as a control group (Group 3). Connecticut Chemosensory Clinical Research (CCCRC) test and the subjective visual analog scale (VAS; 0-100) were utilized to evaluate the olfactory function. Results: There was a statistically significant difference both between the control group and the patient group as well as before and after the HBO therapy in terms of total CCCRC scoring averages and VAS Scoring averages. Conclusion: When compared to normal individuals, type 2 diabetic neuropathy can cause an olfactory dysfunction, and a statistically significant improvement in olfaction can be obtained with HBO therapy. This is the first study demonstrating that the HBO therapy can play a role in treating olfactory dysfunctions suffered by the patients with diabetic olfactory neuropathies.
Symptoms of chronic rhinosinusitis differentially impact general health-related quality of life
Authors: Hoehle L.P. , Phillips K.M. , Bergmark R.W. , Caradonna D.S. , Gray S.T. , Sedaghat A.R.
Published: January 2022

Background: The degree to which different sinonasal symptoms contribute to the overall quality of life (QOL) detriment in chronic rhinosinusitis (CRS) patients remains unknown. In this study we sought to characterize the effect of different CRS symptoms on the general health-related QOL in patients. Methodology: We performed a prospective cross-sectional study of 131 adult patients with CRS. Sinonasal symptoms were evaluated using the 22-item Sinonasal Outcomes Test (SNOT-22) and general health-related QOL was evaluated using the EuroQol 5-Dimensional general health-related QOL survey (EQ5D) and visual analog scale (EQ5D-VAS). Health utility values (HUV) were determined using responses to the EQ5D. SNOT-22 scores were broken down into subdomain scores for sleep, nasal, otologic/facial pain and emotional function symptoms. Results: The otologic/facial pain subdomain score consistently had the largest impact on EQ5D-VAS and HUV. After otologic/facial pain, the sleep subdomain score had the second largest effect while the nasal subdomain score had the least impact on general health-related QOL. Conclusions: Different types of CRS symptoms - most prominently otologic/facial pain and sleep-related symptoms - and their underlying pathophysiologic mechanisms may differentially affect the general health-related QOL detriment associated with CRS. These findings raise the possibility that treatment of the various symptoms associated with CRS may lead to differential improvement in general-health related QOL.
Quality of life after primary septorhinoplasty in deviated- and non-deviated nose measured with ROE, FROI-17 and SF-36
Authors: Bulut O.C. , Wallner F. , Hohenberger R. , Plinkert P.K. , Baumann I.
Published: January 2022

Background: Quality of life measurements are gaining in importance. The present study was conducted with the aim to compare patient satisfaction after septorhinoplasty according to their preoperative nasal deformity. Methods: The patients completed two disease-specific questionnaires before their surgery: the Functional Rhinoplasty Outcome Inventory (FROI-17), the Rhinoplasty Outcome Evaluation (ROE) and as a general instrument, the Short Form 36 Health Survey (SF-36). The second measurement was taken during an outpatient examination 12 months after their primary septorhinoplasty. Patients were grouped in nasal axis deviation (NAD), nasal hump deformity (NHD) and NAD plus NHD. Additionally the patients with preoperative NAD and NAD+NHD were combined as deviated nose and compared to the non-deviation group. Results: One hundred and two patients (51 male and 51 female) underwent primary septorhinoplasty. The ROE- and the FROI-17 overall score including all three subgroups showed significant postoperative improvements. Regarding the SF-36, the postoperative score improved significantly only in two scales (role-functioning physical and mental health). Looking at the the different QoL questionnaires, there were significant postoperative differences in regards to deviated versus non-deviated nose in the FROI-17 overall- and FROI-17 subscores (nasal and general symptoms) and in three scales of the SF-36 (vitality, social functioning, role-functioning emotional), showing a greater postoperative satisfaction in the deviated-nose patient. Conclusion: Patients with and without nasal deviation showed improved QoL after their surgery, as measured with the ROE, the FROI-17 and the SF-36. The patients with a nasal deviation showed a significantly better outcome, as measured with the FROI-17, in comparison with the non-deviated group.
Role of Fe2+-dependent Reaction in Biodecolorization of Methyl Orange by Brown-rot Fungus Fomitopsis pinicola
Authors: Purnomo Adi Setyo , Asranudin  , Rachmawati Nela , Rizqi Hamdan Dwi , Nawfa Refdinal , Putra Surya Rosa
Published: January 2022

The involvement of Fenton reaction on biodegradation of methyl orange (MO) by brown-rot fungus Fomitopsis pinicola was investigated based on Fe2+-dependent reaction. The degradation of MO (final concentration 75 mg/L) was performed in mineral salt media with and without Fe2+ with incubation period at 0, 7, 14, 21, and 28 days. Degradation analysis was performed using UV-Vis Spectrophotometer and LC-TOF/MS. F. pinicola decolorized MO in a medium containing Fe2+ and a medium that lacked the mineral, at percentages of 89.47% and 80.08%, respectively. The optimum decolorization occurred after 28 days of incubation with the fungus on the presence of Fe2+, indicated that the presence of Fe2+ enhanced MO degradation with assumed to correlate with Fenton reaction. Two metabolites were detected through the LC-TOF/MS analysis, namely 4-(2-(4-(dimethyliminio)-2-hydroxycyclohexa-2,5-dien-1-ylidene) hydrazinyl) phenolate (m/z 258, RT: 1.28 min, compound 1) and 4-(2-(4-(dimethyliminio) cyclohexa-2,5-dien-1-ylidene) hydrazinyl) benzenesulfonate (m/z 391, RT: 2.70 min, compound 2). Compound 1 was a transformation product of hydroxylation and methylation, compound 2 was a product of dehydroxylation and desulfonation. This study indicated that the transformation of the metabolite structures was involved hydroxyl radical (OH.) and enzymatic mechanisms, which involved Fe2+-dependent reaction.
Implementation of Dimer-based Screening System in Escherichia coli BL21(DE3) for Selection of Actinomycetes Compounds as Anti-HIV Candidate
Authors: Sukma Kenia Permata , Destiani Putri Cahya , Fibriani Azzania
Published: January 2022

Actinomycetes are reported to have inhibitory activity against several types of Human Immunodeficiency Virus proteases, enzyme with major role in the process of maturation of the virus thus it can infect new cells. Therefore, exploration of Indonesia’s actinomycetes species is expected to be a breakthrough for HIV treatment. In this study, selection of anti-HIV candidate compounds was conducted using a dimer-based screening system on recombinant Escherichia coli BL21(DE3). The construct includes the fusion of the AraC DNA binding domain + HIV-1 protease as the regulator and the green fluorescence protein as the reporter. Confirmation of the plasmid construct was carried out by PCR which showed size of ~1,076 bp. Sequencing analysis proved 100% similarity and identity between construct used in this study and one previously designed. SDS-PAGE showed the presence of band in the size of ~24 kDa equal to the size of the fusion protein. Compounds BLH 1-12 (2) EA, MAE 1-13 EA, BLH 1-1 EA, BLH 7-5 MetA, LC 98 (1) EA, exhibited consistent and significant protease-HIV inhibitory activity at certain concentrations. Thus, in this study, dimer-based screening system is considered to be able to detect actinomycetes as a new anti-HIV candidate for the protease inhibitor group.