bluuebunny/crossref_metadata_2025 huggingface dataset:
AS MEMÓRIAS NARRADAS POR IDOSOS SOBRE O TEMPO ESCOLAR
Authors: Bernardo Renata , Anjos Daniela Dias dos , Pereira Lícia Martins
Published: February 2021

O presente projeto teve como objetivo oportunizar o desenvolvimento de uma aprendizagem humanista com alunos do Curso de Pedagogia, a partir de entrevistas narrativas com idosos que vivem no Asilo São Vicente de Paula, instituição que se localiza na cidade de Bragança Paulista, sobre suas memórias e experiências de escola. O foco desta pesquisa centrou-se nas narrativas de idosos sobre suas memórias escolares, no tocante às experiências que trazem em sua história de vida, em específico no tempo vivido referente à escola. Como objetivo mais amplo o projeto teve a intenção de oportunizar a humanização dos estudantes do Curso de Pedagogia a partir da vivência com os idosos, conhecendo suas experiências e memórias escolares, sendo que, especificamente, a pesquisa pretendeu: desenvolver o conhecimento da história e memória da educação escolar local e regional através das memórias escolares dos idosos da referida instituição; identificar as possibilidades e limites da pesquisa em educação através das narrativas de idosos sobre o tempo escolar.  A pesquisa é de caráter qualitativo aproximando-se dos estudos biográficos na educação, tendo como suporte metodológico entrevistas narrativas. Nas narrativas os idosos apontaram várias condições a partir de suas lembranças do tempo escolar como: o papel do professor em suas trajtórias de vida, os processos de exclusão e punição vividos na escola, bem como a condição social da infância a partir da segunda metade do século XX.
PERFIL EPIDEMIOLÓGICO DOS PACIENTES ATENDIDOS NO SETOR DE FISIOTERAPIA EM ORTOPEDIA E TRAUMATOLOGIA DA CLÍNICA ESCOLA DE FISIOTERAPIA DA UNIVERSIDADE SÃO FRANCISCO
Authors: FUSARO CLAUDIO
Published: February 2021

O objetivo do estudo foi avaliar o perfil dos pacientes que apresentam disfunções ortopédicas, traumatológicas e reumatológicas atendidos no período compreendido entre fevereiro de 2015 a dezembro de 2016, na clínica-escola do curso de fisioterapia da Universidade São Francisco. Trata-se de um estudo de caráter retrospectivo, com informações colhidas nos prontuários do setor de Fisioterapia em Ortopedia e Traumatologia da Clínica Escola de Fisioterapia da Universidade São Francisco no período compreendido entre fevereiro de 2015 e dezembro de 2016. Verificou-se que a idade média de acometimento foi de 48 ± 35 anos, com maior prevalência do sexo feminino, com 57,47%. A região mais acometida foi a região do joelho, com 20% dos casos, e a origem de encaminhamentos foi o HUSF, com 39,08%. Conclui-se que o perfil do paciente atendido na Clínica-Escola de Fisioterapia da Universidade São Francisco é do gênero feminino com acometimento do membro inferior, sendo prioritariamente encaminhado pelo serviço do HUSF.
FERRAMENTA PARA AUTOMATIZAÇÃO DO PROCESSO DE CONCESSÃO DE CRÉDITO UTILIZANDO DE CONCEITOS DE INTELIGÊNCIA ARTIFICIAL
Authors: Dantas Gustavo , Godoi Lucas Felipe , Neto Silvio Petroli
Published: February 2021

Tendo em vista o aumento da competitividade do mercado, as empresas estão cada vez mais oferecendo facilidades no pagamento dos títulos, com condições diferenciadas e prazos de pagamento maiores, com isso o risco de inadimplência também aumenta e o trabalho dos analistas no processo de concessão de crédito é dificultado. Este trabalho tem como objetivo apresentar uma ferramenta utilizando do conceito de redes neurais artificiais, mais especificamente baseadas no algoritmo Multilayer Perceptron (MLP), para auxiliar a tomada de decisão de analistas de crédito de empresas com um modelo de negócios baseado no Business to Business (B2B). Para isso, é utilizado um banco de informações contendo, não apenas o histórico de pagamento do cliente, mas sua representatividade no mercado em que se insere. Os resultados mostram que esse tipo de ferramenta tem um grande potencial para auxílio no processo de análise para concessão de crédito tendo em vista que mesmo com um número limitado de dados que foram utilizados para treinamento da rede neural a ferramenta desenvolvida neste trabalho apresentou uma precisão de mais de 90% de acerto e que, em um cenário real, o número de variáveis disponíveis para captação de informações tende a ser maior. Com isso pôde-se concluir que a implementação dessa ferramenta em uma empresa com uma disponibilidade maior de informações irá apresentar uma performance aceitável para os padrões de mercado.
Analisis Intention Transaction Pada Usaha Mikro Kecil dan Menengah (UMKM) Berbasis E-Commerce di Kota Padang
Authors: Yonaldi Sepris , Darma Ilham Agustin
Published: February 2021

UMKM yang ada di kota Padang kurang efektivitas dan efisiensi dalam proses penjulan yang disebabkan masih rendahnya penggunaan teknologi e-commerce. Selain itu kurangnya informasi bagi pelaku UMKM tentang pengaruh adopsi e-commerce dalam peningkatan daya saing dan kinerja untuk pengembangan UMKM yang lebih maju di masa yang akan datang. Tujuan penelitian ini adalah: untuk mengetahui pengaruh perceived of risk dan perceived enjoyment terhadapintention transaction pada umkm yang menggunakan e-commerce di kota padang, untuk mengetahui pengaruh perceived of risk melalui perceived enjoyment terhadap intention transaction, dan untuk mngetahui pengaruh perceived enjoyment melalui perceived of risk terhadap intention transaction. Penelitian ini menggunakan metode kuantitatif dengan pendekatan explanatory. Survey ke lapangan juga dilakukan untuk mendapatkan data primer dari UMKM yang berada di kota Padang yang sudah menggunakan e-commerce untuk menjalankan bisnisnya. Hasil peneitian ini adalah: a) Variabel perceived of risk, tidak berpengaruh terhadap intention transaction pada UMKM berbasis e-commerce di kota Padang, b) Variabel perceived enjoyment tidak berpengaruh terhadap intention transaction pada UMKM berbasis e-commerce di kota Padang, c) Variabel perceived of risk melalui perceived enjoyment terhadap intention transaction tidak berpengaruh signifikan terhadap intention transaction, d) Variabel perceived enjoyment melalui perceivd of risk terhadap intention transaction tidak berpengaruh signifikan terhadap intention transaction.
Whole-body computed tomography is safe, effective and efficient in the severely injured hemodynamically unstable trauma patient
Authors: Ordoñez Carlos Alberto , Parra Michael , Holguín Alfonso , Garcia Carlos , Guzmán-Rodríguez Monica , Padilla Natalia , Caicedo Yaset , Orlas Claudia Patricia , Garcia Alberto , Rodríguez-Holguín Fernando , Serna Jose Julian
Published: February 2021

Trauma is a complex pathology that requires an experienced multidisciplinary team with an inherent quick decision-making capacity, given that a few minutes could represent a matter of life or death. These management decisions not only need to be quick but also accurate to be able to prioritize and to efficiently control the injuries that may be causing impending hemodynamic collapse. In essence, this is the cornerstone of the concept of Damage Control Trauma Care. With current technological advances, physicians have at their disposition multiple diagnostic imaging tools that can aid in this prompt decision-making algorithm. This manuscript aims to perform a literature review on this subject and to share the experience on the use of Whole Body Computed Tomography as a potentially safe, effective, and efficient diagnostic tool in cases of severely injured trauma patients regardless of their hemodynamic status. Our general recommendation is that, when feasible, perform a Whole-Body Computed Tomography without interrupting ongoing hemostatic resuscitation in cases of severely injured trauma patients with or without signs of hemodynamic instability. The use of this technology will aid in the decision-making of the best surgical approach for these patients without incurring any delay in definitive management and/or increasing significantly their radiation exposure.
Damage Control in Penetrating Liver Trauma: Fear of the Unknown
Authors: Ordoñez Carlos Alberto , Parra Michael , Millan Mauricio , Caicedo Yaset , Guzman Monica , Padilla Natalia , Salamea Juan Carlos , Garcia Alberto , Gonzalez Adolfo , Pino Luis Fernando , Herrera Mario Alain , Rodriguez Fernando , Serna Jose Julian , Salcedo Alexander , Aristizabal Gonzalo , Orlas Claudia Patricia , Ferrada Ricardo , Scalea Thomas , Ivatury Rao
Published: February 2021

The liver is the most commonly affected solid organ in cases of abdominal trauma. Management of penetrating liver trauma is a challenge for surgeons but with the introduction of the concept of damage control surgery accompanied by significant technological advancements in radiologic imaging and endovascular techniques, the focus on treatment has changed significantly. The use of immediately accessible computed tomography as an integral tool for trauma evaluations for the precise staging of liver trauma has significantly increased the incidence of conservative non-operative management in hemodynamically stable trauma victims with liver injuries. However, complex liver injuries accompanied by hemodynamic instability are still associated with high mortality rates due to ongoing hemorrhage. The aim of this article is to perform an extensive review of the literature and to propose a management algorithm for hemodynamically unstable patients with penetrating liver injury, via an expert consensus. It is important to establish a multidisciplinary approach towards the management of patients with penetrating liver trauma and hemodynamic instability. The appropriate triage of these patients, the early activation of an institutional massive transfusion protocol, and the early control of hemorrhage are essential landmarks in lowering the overall mortality of these severely injured patients. To fear is to fear the unknown, and with the management algorithm proposed in this manuscript, we aim to shed light on the unknown regarding the management of the patient with a severely injured liver.
¿Qué es el «hombre»? Una vindicación postmetafísica del sujeto
Authors:   IES Profesor Juan Pulido Castro (España)
Published: February 2021

The eagerness of the human being to understand himself is at the base of all philosophical reflection. Through dialogue with authors such as Tugendhat, Heidegger, Sartre or Aristotle, in this paper the importance of the anthropological question is claimed as a fundamental philosophical question and the validity of an answer to this question is claimed: the one that finds the decisive aspect in freedom of the human condition.
Cartografía de la envidia. El caso de Abel Sánchez
Authors:   Universidad de Zaragoza (España), Ledesma de la Fuente Álvaro
Published: February 2021

We are going to analyse the issue of alterity in the philosophy of Miguel de Unamuno through the study of Abel Sánchez. In this nivola, Unamuno examines the concept of envy and establishes the bases of a theory of alterity based on the specular relationship with the other, which it is constituted by the scarcities of the one who looks. We will also look at what are the philosophical premises of this narration, in which way it is linked with the organic philosophy of Unamuno, and what its relationship with the theatre piece El Otro is, released more than a decade after but of a quite similar subject. Finally, we will outline a possible theory of the alterity by Unamuno that it is formulated through the fraternity and altruistic help.
Investigating efficiency improvement in sulfur recovery unit using process simulation and numerical modeling
Authors: Fazlollahi Farhad , Asadizadeh Sajjad , Khoshooei Milad Ahmadi , Birjandi Mohammad Reza Sardashti , Sarkari Majid
Published: February 2021

Hydrogen sulfide exists mostly as a detrimental byproduct in the gas processing units as well as refineries, and it must be eliminated from natural gas streams. In a Sulfur Recovery Unit (SRU), hydrogen sulfide is converted into the elemental sulfur during the modified Claus process. Efficiency of sulfur recovery units significantly depends on the reaction furnace temperature. In this work, the effect of oxygen and acid gas enrichment on the reaction furnace temperature and accordingly on sulfur recovery is studied, using both numerical modeling and process simulation. Then, simulation and numerical model are benchmarked against the experimental data of an SRU unit. The validated model provides spotlight on optimizing the upstream sulfur removal unit as well as the oxygen purification process. Two cases of acid gas streams with low and high H2S content, 30% and 50%, are studied to investigate the effect of operating parameters on the overall recovery. Finally, average errors of the models are presented. According to the absolute difference with experimental values, the developed numerical model shows great potential for accurately estimating overall efficiency of the recovery unit.
The Effect of Thiamine Supplementation for Critically Septic Patient: An Evidence-Based Case Report
Authors: Sari Ayu Diandra , Putri Melyarna , Angelia Sheena R. , Daya Mulianah , Saraswati Anak Agung Eka Widya , Andayani Diyah Eka , Sunardi Diana
Published: February 2021

Sepsis has been accounted for various burdens worldwide, especially in critically ill patients. This could eventually lead to inflammatory response, provocation ischemia and lactic acidosis. On the other hand, thiamine was suggested as a coenzyme which could improve the outcome of those patients. Thus, we conducted an evidence-based case study with research on PubMed, ProQuest, and Scopus using a search strategy focusing on RCT or cohort study on thiamine supplementation/level towards the outcome of critically ill patients with sepsis. We found three articles eligible for review after full-text assessment. Articles were appraised using the University of Oxford’s tools for critical appraisal. It was known that all studies were good in terms of validity and applicability. This study showed that thiamine supplementation could improve lactate clearance and reduce mortality risk, moreover, thiamine deficiency could increase the risk of lactate acidosis. However, a high level of thiamine was associated with a high level of lactate in patients with liver failure. Therefore, thiamine supplementation could be recommended for critically ill patients with sepsis and normal liver function. Further research, such as RCT or systematic review on thiamine supplementation for age groups to make this study more applicable.
The Potential of Seaweed Salt as an Alternative Low Natrium Salt: Safety and Sensory Test
Authors: Notowidjojo Lindarsih , Ascobat Purwantyastuti , Bardosono Saptawati , Tjahjana Jana
Published: February 2021

Indonesia is one of the largest producers of red seaweed in the world, but there is very little research done on the role of red seaweed in the health sector. This study is about red seaweed type Euchema cottoni and it’s potential as seaweed salt that has lower natrium and rich in other minerals.This research was divided into two phases and conducted from December 2016 to March 2017. The first phase is a safety analysis in terms of metal, mold and bacteria contamination of seaweed from three different places of Indonesia: Saumlaki, Maluku; Nusa Dua, Bali and Flores, Nusa Tenggara Barat. After the seaweed safety was selected, the seaweed was made into powder at Industrial Research and Development Agency (BPPT), Tangerang. The seaweed powder mixed with ordinary salt with four type of concentrations were subjected to a salty sensory test by nine panellists who have been working at the food production at Hospital for at least one year. The second phase was to do acceptance sensory test of the seaweed salt product taste against a concentration that was selected in first phase to first-degree hypertensive subjects aged 25–59 years by using soup as the meal-media. Chi-square test was used to analyse the difference.Seaweed from Saumlaki, Maluku was selected as the safest seaweed due to it’s lowest content of metal, mold and bacterial contaminations. The ratio of seaweed powder to ordinary salt powder 1:1 was selected by nine panellists in salty sensory test. Analysis of minerals from the seaweed salt product found that besides the lower sodium and Iodium content, it’s potassium and magnesium content were much higher than ordinary salt. Salty taste test by 62 respondents with first degree hypertension with age 25-59 years showed no significant difference in saltiness between seaweed salt and ordinary salt.In conclusion, the seaweed salt product with a 1:1 ratio to ordinary salt powder is safe and acceptable to be used as an alternative low Na salt.
Fatores facilitadores e dificultadores para a prática de notificação de eventos adversos por enfermeiros
Authors: Pereira Júnia Aparecida , Amaro Marilane de Oliveira Fani , De Mendonça Érica Toledo , Domingos Camila Santana , Siman Andréia Guerra , De Carvalho Camilo Amaro
Published: February 2021

Objetivo: Identificar os fatores facilitadores e dificultadores envolvidos no processo de notificação de eventos adversos em saúde realizadas pelos enfermeiros que atuam em um hospital da Zona da Mata Mineira. Métodos: Estudo de caso qualitativo realizado por meio de entrevista com roteiro semiestruturado com a participação de 25 enfermeiros. Os dados foram submetidos a análise de conteúdo. Resultados: A partir dos depoimentos, emergiram duas categorias temáticas: Aspectos facilitadores para a realização da notificação de eventos adversos à saúde e “Notificação de eventos adversos: desafios vivenciados pela equipe de enfermagem”. A primeira categoria evidenciou a comunicação eficaz, o trabalho em equipe e o aprendizado a partir da notificação como aspectos que facilitam a realização das notificações.  Por sua vez, a segunda categoria apontou a cultura punitiva, a falta de feedback e a sobrecarga de trabalho como aspectos dificultadores. Conclusão: Os profissionais de saúde em sua prática cotidiana, vivenciam a ocorrência de eventos adversos e reconhecem que o processo de notificação é um aspecto fundamental para a promoção da segurança do paciente. Conhecer e determinar a real magnitude dos eventos adversos, é questão primordial para uma gestão de qualidade nas instituições promotoras do cuidado.
Great Expectations, Uncertain Futures. Urban and Online Encounters with Youth, Love and Marriage in Egypt
Authors: Jyrkiäinen Senni , Bisset Victoria
Published: February 2021

For young Egyptians, the economic and social instability of recent years has led to a prolonged period of youth with marriage, a key life event, now occurring later in life. Although social media and greater access to higher education have created more opportunities for unmarried men and women to meet, and have at least in principle paved the way for young people to marry for love, in practice, issues such as a lack of financial means and the pressure for women to marry soon after graduation mean that such marriages remain the exception rather than the norm.
Ethnobiological knowledge generation during “herding games” in pastoralist Maasai society (southern Kenya)
Authors: Tian Xiaojie
Published: February 2021

Savoir ethnobiologique engendré durant les « jeux de conduite de troupeau » dans la société Maasai pastoraliste (sud Kenya). Cet article explore la production du savoir ethnobiologique relatif au bétail par les enfants Maasai du sud du Kenya, à travers des jeux de conduite de troupeau. Dans la communauté Maasai qui continue à utiliser et à gérer collectivement les terres, les enfants prennent part activement aux tâches quotidiennes liées au bétail, lesquelles servent de cadre à la production du savoir ethnobiologique. Pendant le jeu, les enfants mettent en pratique et communiquent leurs compétences relatives au bétail, tout en les ajustant aux conditions sociales et environnementales actuelles, et en mettant en scène les relations sociales qu’ils découvrent au fil de leurs tâches quotidiennes. L’étude met en lumière la pertinence du jeu dans la construction du savoir ethnobiologique dans des contextes sociaux pastoraux durant les jeux de bétail. Ce faisant, les enfants contribuent à l’enrichissement des relations homme-bétail-environnement dans la société Maasai actuelle.
Coco, l’« enfant du patrimoine » ? Sur la représentation de la fête des morts au Mexique à partir d’un « dessin animé patrimonial »
Authors: de Suremain Charles-Édouard
Published: February 2021

Le patrimoine, à travers le dessin animé Coco, semble avoir trouvé un mode d’expression et de transmission inédit, à ce point qu’il apparaît désormais concevable de parler d’un nouveau genre cinématographique, le « dessin animé patrimonial ». Véritable production destinée à la scène globale, combinant créativité, invention et hommage à l’« âme d’un peuple », le film met en avant la « culture mexicaine » perçue par la « culture latino », tout en rappelant les valeurs fondatrices de la Nation mexicaine : la tradition, les ancêtres, la famille… et l’enfant ; au-delà, il reprend les questions universelles relatives à la condition humaine : la vie, la mort. Figure centrale d’une trame narrative à la fois dramatique et humoristique, l’« enfant du patrimoine » reflète les tensions actuelles entre le modèle de l’enfant du droit fortement doté d’agencéité – qui tente de s’affranchir de l’ordre social traditionnel pour une part – et le modèle d’enfant consumériste qui va jusqu’à tenter d’imposer ses choix aux adultes pour l’autre. Le dessin animé patrimonial montre en creux que, pour avoir une chance d’être transmis, le patrimoine ne peut s’appuyer sur un récipiendaire abstrait, un enfant générique, mais qu’il doit s’incarner dans un acteur fait de chair et d’os, avide de biens de consommation culturels, devenu entre-temps expert en patrimoine.
Modern content and improvement of high cardiovascular risk strategy in reducing mortality from cardiovascular diseases
Authors: Boytsov Sergey A. , Drapkina Oksana M.
Published: February 2021

The article describes the modern content of the high-risk strategy, which, along with the population strategy, forms the basis of a set of measures to reduce mortality from cardiovascular diseases. The high cardiovascular risk strategy is carried out at the individual level in outpatient structures as a part of primary and secondary prevention of cardiovascular diseases, and is also implemented in hospitals when performing elective surgical procedures, including high-tech interventions. Improving this strategy within the framework of primary health care involves the development of a system of high-risk offices, telemedicine consulting, remote monitoring of physiological parameters on the basis of a regional medical information system, and in the future, on the basis of a uniform vertically integrated medical information system. The development of the high-risk strategy as a part of inpatient practice occurs through the further replication of high technologies and the implementation of new types of them.
Gallbladder polyps: modern approaches to diagnostics and treatment
Authors: Onuchina Elena V.
Published: February 2021

Gallbladder polyps are an elevation of the mucous membrane that protrudes into the lumen of the gallbladder cavity. Their prevalence in the general population varies from 0.3 to 13.8%. According to the modern classification, polyps of the gallbladder are divided into benign non-tumor, benign tumor and malignant tumor polyps. A review of modern literature presents cohort and randomized controlled trials, including those summarized in meta-analyzes and systematic reviews, suggesting that the dominant form of polypoid formations of the gallbladder are cholesterol pseudo-polyps with no malignant potential associated with impaired cholesterol metabolism, often combined with gallbladder cholesterosis, metabolic syndrome and cardiovascular morbidity. Evidence is building up on the effectiveness of ursodeoxycholic acid for controlling components of the metabolic syndrome and cardiovascular risks. Ursodeoxycholic acid preparations may become promising for the management of cholesterol polyps.
Hepatocellular damage and inflammation in various forms of alcoholic liver disease
Authors: Rodina Alisa S. , Shubina Marina E. , Kurbatova Irina V. , Topchieva Ludmila V. , Dudanova Olga P.
Published: February 2021

Aim. The aim of the study was to evaluate hepatocellular damage and immune inflammation in various forms of alcoholic liver disease (ALD).
Materials and methods. 104 patients with ALD were examined: 15 (14.4%) with liver steatosis (LS), 19 (18.3%) with steatohepatitis and 70 (67.3%) with liver cirrhosis (LC); men 50 (48.1%), women 54 (51.9%); age 45.78.4 years. Traditional clinical, laboratory, instrumental studies were performed, the levels of fragments of cytokeratin-18 (FCK-18), cytokines IL-1, TNF-, IL-4, IL-6, IL-8 were determined by ELISA. The control group consisted of 39 healthy individuals: men 20 (51.2%), women 19 (48.7%), age 48.58.3 years.
Results. In LS, an increase in the level of FCK-18 was noted with normal aminotransferase activity, the content of TNF-, IL-6, IL-1, IL-8 increased and the level of IL-4 decreased compared to those in healthy individuals. In steatohepatitis, a triple increase in aminotransferases and FCK-18 was observed compared with LS, as well as an increase in the level of inflammatory mediators, to a greater extent IL-6, to a lesser extent IL-8, TNF-, a decrease in IL-4, IL-1 remained at the same level. In LC, there was a further increase in FCK-18, significantly more pronounced than an increase in AST, and the increase in cytokines continued to the same extent, the levels of IL-6 and IL-8, to a lesser extent IL-1 and TNF-, and the level of IL-4.
Conclusion. With the progression of ALD from LS to steatohepatitis, hepatic cell damage was carried out by equally pronounced processes of hepatocyte necrosis and apoptosis, with the development of cirrhosis of the liver, parenchyma damage occurred mainly due to hepatocyte apoptosis. The immuno-inflammatory process progressively increased from the stage of LS to LC with IL-6 and IL-8 undergoing the greatest dynamics. FCK-18 can serve as a non-invasive marker of hepatic cell damage, and IL-6 and IL-8 markers of immune inflammation in ALD.
Telomere length as a biomarker of the risk of cardiovascular complications in patients with coronary heart disease
Authors: Doroshchuk Natalia A. , Lankin Vadim Z. , Tikhaze Alla K. , Kheimets Grigory I. , Doroshсhuk Alexander D. , Smirnova Maria D. , Chazova Irina E.
Published: February 2021

Aim. To study the effect of oxidative stress and telomere length in the chromosomes of blood leukocytes in patients with coronary heart disease (CHD) on the development of cardiovascular complications.
Materials and methods. In 119 patients with CHD, the level of oxidatively modified low-density lipoproteins (ox-LDL) in blood plasma and the length of telomeres in nuclear blood cells were determined during the examination. After 5 years, a telephone survey of patients (or their relatives) was conducted to obtain data on the presence of cardiovascular complications. Telomere length was determined using quantitative real-time PCR, and the level of ox-LDL was determined by immunochemical method.
Results. It was found that reducing the length of telomeres in patients with CHD increases the risk of subsequent development of cardiovascular complications. A strong negative correlation was found between the level of ox-LDL and telomere length in the group of examined CHD patients who had cardiovascular complications after 5 years.
Conclusion. CHD patients with short telomere length and high levels of ox-LDL have an increased risk of cardiovascular complications during 5 years.
Dynamics of adreneractivity after transfer of myocardial infarction: annual observation
Authors: Rebrova Tatiana Y. , Muslimova Elvira F. , Alexandrenko Victoria A. , Afanasiev Sergey A. , Garganeeva Alla A. , Maksimov Ivan V.
Published: February 2021

Aim. To study the change in the -adrenergic reactivity of red blood cell membranes in patients during the first year after acute myocardial infarction.
Materials and methods. The study included 25 patients with acute myocardial infarction (AMI) who signed informed consent to participate in the study. The erythrocyte membrane -adrenoreactivity index (-ARM) was determined in venous blood samples upon admission to the intensive care unit, one day after admission, 6 and 12 months after the index MI was transferred using the BETA-ARM-AGAT reagent kit (Agat-Med, Russia).
Results. According to the results of dynamics assessment of -APM during the first day, patients included in the study were divided into 2 groups. Group 1 (n=14) included patients who had an increase in -APM in the first day, and group 2 (n=21) included patients in whom -ARM either did not change or decreased. At the time of admission to the hospital in the formed groups, there were no differences in the -APM index and clinical and anamnestic characteristics. A day after hospitalization, the value of -APM in group 1 significantly exceeded the same indicator in group 2 (p=0.02). At the periods of 6 and 12 months, the -APM indices in the groups did not differ. In the 2nd group of patients, the progression of chronic heart failure to one or more functional classes (NYHA) was significantly more often compared with the 1st group.
Conclusion. The study showed that on the first day in patients with AMI, both an increase and a decrease in the activity of the sympathoadrenal system are possible with a further leveling of these differences over the next year. For a group of patients with decreased activity of sympathoadrenal system on the first day, a more unfavorable course of heart failure in the post-infarction period is characteristic.
Work life balance of women employees of teaching faculties in karnataka state
Authors: R Dr.Sunitha
Published: February 2021

The role of working women has changed throughout the world due to economic conditions and social demands. This has resulted in a scenario in which working women have tremendous pressure to develop a career as robust as their male counterparts while sustaining active engagement in personal life. The ever- increasing work pressure is taking a toll on the working women leaving them with less time for themselves. The increasing responsibilities on the personal front with the technological blessings like advanced mobile phones, notepads, etc. that keeps work life integrated with personal life also creates stress on personal and professional fronts in this knowledge age. This affects the person’s physical, emotional and social well-being. Thus, achieving work life balance is a necessity for working women to have a good quality of life. This paper is an attempt to explore the tough challenges faced by working women in maintaining a balance between their personal and professional life. The various factors affecting the work-life balance of married working women have been examined in this study. The tool used for the study is the manual on work–life balance of The Industrial Society (now the Work Foundation) by Daniels and McCarraher. Data were subjected to descriptive statistics and it was found that the problems faced by the working women of ts in terms of work-life balance are quite high. The results also indicate that the work-life balance of individuals affect their quality of life.
Experiences of Slovenian In-Service Primary School Teachers and Students of Grades 4 and 5 with Outdoor Lessons in the Subject Science and Technology
Authors: Novljan Maruša , Pavlin Jerneja
Published: February 2021

The present paper presents the results of a survey on outdoor lessons conducted by teachers of the subject Science and Technology in the 4th and 5th grades of primary school in the school’s vicinity. It examines differences between teachers themselves and between teachers and students, as well as the ideas and limitations of outdoor lessons. The study included 70 in-service primary school teachers of the 4th and 5th grades and 154 students of the 4th grade and 151 students of the 5th grade of primary school. The data were obtained with two questionnaires: an e-questionnaire for teachers and a paper-pencil questionnaire for students. The results show that 13 per cent of teaching time in the subject Science and Technology consists of outdoor lessons. Statistically significant differences were found between teachers with different amounts of teaching experience, while differences in the quantity of outdoor lessons did not arise among teachers of different school strata and among teachers who had an early experience with outdoor lessons in the vicinity of school themselves as students compared to teachers who had no such experience. The teachers had several specific and general ideas for outdoor activities for the thematic sets of the Science and Technology curriculum and reported similar difficulties in planning outdoor lessons to those reported in other countries. The results of the research show that the teachers report the use of outdoor lessons in the vicinity of school more often than recalled by the students. The students reported that such activities typically take place about twice a year, mostly in playgrounds, meadows, and forests. The results provide an insight into the state of the teachers’ initiatives for outdoor lessons in the subject Science and Technology and indirectly offer opportunities to reflect and act on outdoor lessons from different perspectives.
Wear Resistance of 304 Austenitic Stainless-steel Friction Welded Joints
Authors: khaleal Jwan , Gardi Ramadan , Ramadan Dlair
Published: February 2021

In the present work, similar joint of AISI 304 austenitic stainless steel with a designed joint interface by 6 mm diameter and 6 mm depth, were processed by rotary friction welding route. Different parameters including forging pressure (192.4, 240.5, 288.6 and 384.8 MPa), friction pressure (192.4 MPa), frictional speed (560 RPM) and frictional time (1min) are examined. Pin on disc wear tester was used for wear test with counter disc SAF 2205 duplex stainless steel and cylindrical AISI 304 pin specimens. The surface roughness of duplex stainless-steel disc was measured. The wear rate in terms of weight loss were obtained for the pin specimens. The results of designed joint interface specimens showed better wear resistance than as-received. The variation of increasing wear loss with sliding distance has been found to be uniform for all the specimens. Further, it was noted from the experiments that the wear rate increased with increasing forging pressure.
The Dynamic Regulatory Role of miR-132 in Adult Hippocampal Neurogenesis and Neural Stem Cell Development
Authors: Chen David , Lee Seungmin
Published: February 2021

Introduction: Neurogenesis and neural stem cell development in the adult hippocampus remains an understudied and controversial area of research. These processes are known to be regulated by the dynamic interplay of transcription factors, cell-niche signalling, and recently, microRNAs. microRNA-132 (miR-132) is one example of a miRNA that offers critical insight into neurogenesis and neural stem cell development. The aim of this study was to systematically review the current literature regarding the role of miR-132-mediated post-transcriptional regulation of adult hippocampal neurogenesis (AHN) and neural stem cell (NSC) development.
Methods: The literature search consisted of research articles found in PubMed, MEDLINE, Google Scholar, Cochrane, and Scopus databases using combinations of the Medical Subject Headings (MeSH) keywords “micro-RNA 132”, “miR-132”, “adult hippocampal neurogenesis”, and “neural stem cell development” to filter initial results. The study abstracted data in regards to the modalities of miR-132-mediated post-transcriptional regulation and the histophysiological implications associated with AHN and NSC development.
Results: miR-132 has been implicated in mediating AHN as well as NSC differentiation and integration into the adult hippocampal dentate gyrus. Knockdown and overexpression of micro-RNA 132 in studies have demonstrated that miR-132 acts as a regulator of several downstream pathways and biochemical targets, including p250-GAP, methyl CpG-binding protein 2, AMPA glutamate receptors, and the RAS/MAPK axon signaling pathway. The fine-tuned modulation of neuronal plasticity associated with miR-132 suggests a role in higher level cognition, learning, and neurodegeneration within the context of Alzheimer’s disease.
Discussion: The findings that miR-132 serves as a regulator of AHN and NSC development have significant clinical implications, specifically towards better understanding the pathological basis of neurodegenerative disorders as well as the development of novel miRNA-based therapeutics.
Conclusion: The systematic review aggregated key findings on multiple potential biochemical targets and downstream feedback regulation pathways associated with miR-132 expression. Further research is needed to elucidate the mechanism of each pathway and the potential interplay between multiple proteins regulated by miR-132 that are associated with clinical disorders such as Alzheimer’s disease.
General Assessment of Calcium-Phosphorus Metabolism and Vitamin D Levels in Patients with Chronic Pancreatitis and Chronic Obstructive Pulmonary Disease
Authors:   Higher State Educational Establishment of Ukraine Bukovinian State Medical University. 2, Theatralna Sq., Chernivtsi 58002, Ukraine, Lazaruk T. Yu. , Fediv O. I.
Published: February 2021

Our attention was drawn to the comorbidity of chronic pancreatitis and chronic obstructive pulmonary disease, namely the features of clinical and pathogenetic links. The article examines metabolism of vitamin D, parathyroid hormone and calcium-phosphorus metabolism in patients with this comorbidity and considering exocrine insufficiency. The results of our own research in this direction are presented. The purpose of the study was to determine the nature of the exocrine pancreatic insufficiency effect on the metabolism of vitamin D, parathyroid hormone and calcium-phosphorus metabolism. Material and methods. The study included 30 patients with exacerbation of chronic pancreatitis and 50 patients with a diagnosis of chronic pancreatitis in the acute stage and chronic obstructive pulmonary disease aged 47-55 years (average age – 52.36±1.83 years). All patients had chronic pancreatitis for more than 10 years. Inclusion criteria was the presence of exocrine pancreatic insufficiency and changes of vitamin D in patients’ metabolism. Patients were hospitalized in the gastroenterology department of the Regional Clinical Hospital, Chernivtsi, Ukraine in connection with exacerbation of chronic pancreatitis. Chronic obstructive pulmonary disease was in stable or unstable remission. Respondents were informed about the study and gave their consent. The control group consisted of 20 healthy individuals. Results and discussion. We revealed a complication of the clinical course in patients with chronic pancreatitis and chronic obstructive pulmonary disease on the background of exocrine pancreatic insufficiency. One of the manifestations was a violation of the metabolism of vitamin D, parathyroid hormone and calcium-phosphorus metabolism. Correlation analysis revealed a positive relationship between levels of exocrine pancreatic insufficiency and serum vitamin D concentration (p <0.05, r = 0.71). There was a strong inverse correlation between the levels of parathyroid hormone and vitamin D (p <0.05, r = - 0.87), and the content of calcium in the serum (p <0.05, r = - 0.74). Conclusion. Comorbidity of chronic pancreatitis and chronic obstructive pulmonary disease causes severe disorders of mineral metabolism and metabolism of vitamin D
Molecular analysis of aflR gene in Aspergillus flavus isolated from Iran
Authors:   Infectious and Tropical Diseases Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences. International Affairs Office, Ahvaz Jundishapur University of Medical Sciences, Khuzestan Province, 61357-1579, Ahvaz, Iran, Erfaninejad Maryam ,   Department of Medical Mycology, Medical School, Ahvaz Jundishapur University of Medical Sciences. International Affairs Office, Ahvaz Jundishapur University of Medical Sciences, Khuzestan Province, 61357-1579, Ahvaz, Iran, Zarrin Majid ,   Infectious and Tropical Diseases Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences. International Affairs Office, Ahvaz Jundishapur University of Medical Sciences, Khuzestan Province, 61357-1579, Ahvaz, Iran,   Department of Medical Mycology, Medical School, Ahvaz Jundishapur University of Medical Sciences. International Affairs Office, Ahvaz Jundishapur University of Medical Sciences, Khuzestan Province, 61357-1579, Ahvaz, Iran
Published: February 2021

Aspergillus flavus produces the most potent carcinogens, aflatoxins, when it contaminates agricultural crops. aflR gene regulates aflatoxin-related genes and it has been identified in four species of A. flavus, A. parasiticus, A. sojae and A. oryzae. Contamination of agricultural commodities with aflatoxin is a grave risk to humans and animals’ health. Aflatoxin related genes are clustered in a 75 kb region of genome in A. flavus. Investigations obviously demonstrated that aflatoxin biosynthesis needs the aflR gene product and an entirely functional aflatoxin biosynthetic cluster. The purpose of the current study was to investigate the presence of the aflR gene in A. flavus. Material and methods. Forty-two A. flavus isolates including 10 references, 25 clinical and 7 environmental isolates were analyzed in this study. The isolates were identified by morphology. To characterize morphologically, the conidial arrangement, philiades, vesicles and conidiophores were observed microscopically. Using PCR, the aflR gene was amplified with primers aflR1 and aflR2. PCR were carried out to amplify an 800 bp DNA fragment of aflR gene. Some amplicons were sequenced. The sequences were searched in NCBI database and analyzed with MEGA5 software. Results and discussion. Out of 42 A. flavus isolates, an 800 bp band was amplified for 35 isolates. No band was observed for seven isolates including 4 clinical and 3 environmental isolates. Data analysis demonstrated that 100% of reference strains and 84% of clinical strains produced the expected fragment while it was only 57.14% for environmental isolates. The sequences had 100% identity with A. flavus aflR gene which was deposited in the NCBI database. Conclusion. In conclusion, molecular analysis of the aflR gene showed that this gene was not amplified from some strains of A.flavus; therefore, perhaps it lacks the gene or it is greatly abnormal. Additional researches are needed to verify whether the strains with lack of aflR gene have a loss of function in production of aflatoxin or other mechanisms of regulation exist
Medical and Social Justification of the Implementation of the Optimized Model of Prevention of Genetically Determined Reproductive Losses
Authors:   Kharkiv National Medical University. 4, Nauky Avenue, Kharkiv 61022, Ukraine, Alieva T. D. K. ,   Ukrainian Institute of Clinical Genetics. 4, Nauky Avenue, Kharkiv 61022, Ukraine
Published: February 2021

Among the objects of organizational influence of the health care system on reproductive losses, miscarriages and congenital malformations (birth defects) are the most important. Diagnosis of most genetic, chromosomal diseases and malformations of the embryo and fetus is performed using biochemical, cytogenetic, molecular genetic tests and ultrasound diagnostic. Many clinical geneticists focus on birth defects and miscarriages associated with folate cycle disorders related with the greatest number of reproductive losses. We studied levels of homocysteine, folic acid and vitamin B12 in pregnant blood and polymorphic genes C677T MTHFR and A66G MTRR considered due to folate cycle disorders. The purpose of the study was to analyze the organizational aspects of the existing model for the prevention of genetically determined reproductive losses and to propose measures to improve the model. Material and methods. The methods of system approach and analysis, bibliosemantic, prospective, economic, expert assessments provided by the specialty passport (14.02.2003) "Social Medicine" were used for the research. Research period: 2008–2018. Place of research: "Interregional Specialized Medical and Genetic Center – Center for Rare (Orphan) Diseases" of Kharkiv Regional Council. Genetic maps of the archive and own patients, normative-legal acts, data of medical statistics were analyzed. Results and discussion. The study suggested an optimized model for the prevention of genetically determined reproductive losses, which took into account examinations for homocysteine, folic acid, vitamin B12 levels, MTHFR and MTRR genes to find their polymorphism, ultrasound, prevention using diet and vitamin therapy, involving gynecologists, family physicians and clinical geneticists. The principles of accessibility, safety, effectiveness, timeliness, cost-effectiveness, protection of rights and freedoms (non-discrimination), personal orientation, legal basis, cooperation with other medical and non-medical organizations and institutions, prevention character, complexity and variety of forms of physician’s cooperation who provide care to pregnant with reproductive losses in anamnesis, couples planning a pregnancy, newborns with birth defects, chromosomal, genetic diseases and syndromes. The efficient and uninterrupted operation of the developed optimized system is ensured with the participation of "feedback" mechanisms. Adherence to the proposed model will provide an opportunity to significantly reduce reproductive losses in the coming years in Ukraine, provided that its principles are included in the relevant national programs and protocols
An Original Method for Removing and Fixing the Pituitary Gland of Sexually Mature Rats for Creating High-Quality Permanent Histological Preparations
Authors:   Sumy State Univercity. 2, Rymskogo-Korsakova St., Sumy 40007, Ukraine, Hryntsova N. B. , Romanyuk A. M.
Published: February 2021

The issue of high-quality creating histological preparations is an urgent issue of histology and pathological anatomy, experimental medicine and biology. The pituitary gland belongs to the smallest in mass and size of the endocrine glands in both humans and animals, it is an endocrine gland and occupies one of the central places in the endocrine regulation of the body's vital activity. The study of the features of the removal of the pituitary gland from Turkish saddle of the sphenoid bone of the skull of rats remains an important aspect of modern morphology. The purpose of the work was to develop an original technique for improving the first (removal) and second (material fixation) stages of creating histological preparations of the rat pituitary gland for morphological, morphometric, and immunohistochemical medico-biological experimental studies. Material and methods. The development of the methodology was carried out on 200 white sexually mature rats of different sex weighing 250-300 g at the age of 7-8 months in accordance with the National and European bioethical standards. Results and discussion. Modification of the technique of extracting the pituitary gland of rats includes the introduction of the animal into thiopental anesthesia, decapitation, separation of the skin and muscular integument of the head, resection of the occipital bone of the skull, exposure and removal of the brain, identification of the pituitary gland, followed by removal of the pituitary gland with a single complex (block) together with the pituitary fossa Turkish saddle and fragments of the sphenoid bone adjacent to it. The gland was fixed with a reduced concentration of a 5% solution of buffered neutral formalin. After 15-18 hours from the beginning of fixation, the complex was temporarily removed from the fixator, and the pituitary gland was removed from the pituitary fossa of Turkish saddle using eye scalpel and eye forceps. The organ had a well-fixed and compacted capsule, which prevented unnecessary trauma and fragmentation of the organ during removal. The removed pituitary gland was again immersed in a 5% solution of neutral buffered formalin for 2-3 hours. After the end of the fixation period, the pituitary gland had a well-fixed structure and was subject to the following standard stages of making permanent histological specimens