bluuebunny/crossref_metadata_2025 huggingface dataset:
Chinese Herbal Medicines as Natural Alternative Products to Antibiotics in Weaned Piglets through Intestinal Microbiota Regulation
Authors: Wang Che-Hsuan , Chung Kou-Toung , Su Li-Yu , Wu Wan-Jhen , Wang Pei-Hwa , Lee Ming-Chung , Shen Szu-Chuan , Wu Chung-Hsin
Published: October 2024

During the growth process of weaned piglets, digestive problems such as gastrointestinal disorders and diarrhea are common. Farmers usually use antibiotics to help piglets grow smoothly. However, the overuse of antibiotics can lead to antibiotic resistance issues. Therefore, this study chose to use plant extracts as feed additives to explore their potential as alternatives to antibiotics. Additionally, Tilmicosin was used as the antibiotic because it is widely used in treating respiratory infections in piglets. Since traditional Chinese medicine often uses natural products, we selected Guizhi Li-Zhong (GLZ) extract as an alternative to antibiotics. The experiment involved 126 piglets, each 4 weeks old, which were randomly assigned to one of four groups: the sham group (basal diet without supplements, 10.3 ± 0.4 kg, n = 31), the low-dose GLZ group (basal diet with 0.05% GLZ, 10.9 ± 0.4 kg, n = 32), the regular-dose GLZ group (basal diet with 0.2% GLZ, 10.6 ± 0.4 kg, n = 32), and the regular-dose Tilmicosin antibiotic group (basal diet with 0.2% Tilmicosin, 10.2 ± 0.3 kg, n = 31). We recorded and compared the survival rate, growth rate, feed conversion ratio, and diarrhea incidence among four groups of weaned piglets from the 4th to the 10th weeks of age. Then, we examined the oxidative stress, inflammation, and apoptosis in small intestine tissue (jejunum and ileum) through immunohistochemistry and Western blot and compared the gut microbiota in large intestine tissue (colon and rectum) through a next-generation sequencing (NGS) analysis. Our results showed that weaned piglets supplemented with 0.05% and 0.2% GLZ had better survival rates, growth rates (p < 0.01), and feed conversion ratios (p < 0.01) compared to those receiving sham treatment. Even weaned piglets supplemented with 0.2% GLZ performed better than those supplemented with 0.2% Tilmicosin antibiotics (p < 0.05). Furthermore, the incidence of diarrhea and small intestine injury (indicated by oxidative stress-, inflammation-, and apoptosis-related proteins) in piglets supplemented with 0.05% and 0.2% GLZ was lower than in piglets receiving sham treatment (p < 0.05). Even piglets supplemented with 0.2% GLZ had less injury than those supplemented with 0.2% Tilmicosin antibiotics (p < 0.05). The NGS results further showed that GLZ treatment significantly improved beneficial bacteria in weaned piglets (p < 0.05), while antibiotic treatment reduced beneficial bacteria (p < 0.05). In summary, we recommend adding GLZ to the feed as an alternative to antibiotics. This not only effectively reduces intestinal damage but also improves the gut microbiota, thereby promoting the growth of weaning piglets.
Exploring the Role of miR-132 in Rat Bladders and Human Urothelial Cells during Wound Healing
Authors: Chamorro Clara I. , Fossum Magdalena
Published: October 2024

Urinary bladder wound healing shares many features with skin healing, involving several molecular players, including microRNAs (miRs). This study investigated the role of miR-132 in urothelial cells. We analyzed miR-132 expression in rat bladder using in situ hybridization and conducted gain and loss of miR-132 function assays in primary human urothelial cells (HUCs). These assays included cell proliferation and migration studies. To explore the regulation of miR-132 expression, cells were treated with wound-healing-related factors such as interleukin 6 (IL-6), interleukin 10 (IL-10), and transforming growth factor beta-1 (TGF-β1). Predictive bioinformatics and a literature review identified potential miR-132 targets, which were validated through real-time polymerase chain reaction (RT-PCR) and Western blot analysis. miR-132 was found to promote cellular proliferation and migration during the early stages of urothelial wound repair. Its expression was modulated by key cytokines such as IL-6, IL-10, and TGF-β1. miR-132 played a crucial role in urothelial wound healing by enhancing cell proliferation and migration, regulated by cytokines, suggesting its action within a complex regulatory network. These findings highlight the therapeutic potential of targeting miR-132 in bladder injury repair, offering new insights into bladder repair mechanisms.
Decoding Visual Responses: Insights into Chronic Migraine and Medication Overuse Headache with Electrophysiological Analysis
Authors: Coppola Gianluca , Casillo Francesco , Sebastianelli Gabriele , Abagnale Chiara , Di Lorenzo Cherubino , Di Renzo Antonio , Serrao Mariano , Parisi Vincenzo
Published: October 2024

Background/Objectives: Habituation and sensitization are opposite phenomena that play a role in the pathophysiology of episodic migraine and its progression to chronic migraine (CM). There have been just a few studies that have investigated these phenomena in patients with medication overuse headache (MOH) in comparison to those with chronic migraine (CM) and healthy controls (HCs), and the findings have been inconsistent. Methods: We measured and examined visual evoked potentials (VEPs) in 81 patients with MOH and 24 patients with CM, as well as 24 HCs. The VEPs were used to assess sensitization by analysing the amplitude of the first block (100 sweeps) and to evaluate habituation by measuring the amplitude response decrement after six blocks. We further examined patients diagnosed with MOH based on their acute medication type and after a 3-week acute medication withdrawal program. Results: There were no significant differences between groups in terms of the first N1-P1 VEP amplitude block and its habituation. It was found that patients with MOH had a greater drop in the amplitude of the VEP P1-N2 complex after repeated stimulation than patients with CM or HC. The VEP parameters showed no significant differences based on the specific overused drug and after a 3-week acute medication withdrawal. Conclusions: We propose that the results obtained in patients with MOH indicate an abnormal activation of inhibitory circuits in the parieto-occipital region in response to repeated modulatory stimuli.
Intravenous Infusion of Autologous Mesenchymal Stem Cells Expanded in Auto Serum for Chronic Spinal Cord Injury Patients: A Case Series
Authors: Hirota Ryosuke , Sasaki Masanori , Iyama Satoshi , Kurihara Kota , Fukushi Ryunosuke , Obara Hisashi , Oshigiri Tsutomu , Morita Tomonori , Nakazaki Masahito , Namioka Takahiro , Namioka Ai , Onodera Rie , Kataoka-Sasaki Yuko , Oka Shinichi , Takemura Mitsuhiro , Ukai Ryo , Yokoyama Takahiro , Sasaki Yuichi , Yamashita Tatsuro , Kobayashi Masato , Okuma Yusuke , Kondo Reiko , Aichi Ryo , Ohmatsu Satoko , Kawashima Noritaka , Ito Yoichi M. , Kobune Masayoshi , Takada Kohichi , Ishiai Sumio , Ogata Toru , Teramoto Atsushi , Yamashita Toshihiko , Kocsis Jeffery D. , Honmou Osamu
Published: October 2024

Objective: The safety, feasibility, and potential functional improvement following the intravenous infusion of mesenchymal stem cells (MSCs) were investigated in patients with chronic severe spinal cord injury (SCI). Methods: The intravenous infusion of autologous MSCs cultured in auto-serum under Good Manufacturing Practices (GMP) was administered to seven patients with chronic SCI (ranging from 1.3 years to 27 years after the onset of SCI). In addition to evaluating feasibility and safety, neurological function was evaluated using the American Spinal Injury Association Impairment Scale (AIS), International Standards for Neurological Classification of Spinal Cord Injury (ISCSCI-92), and Spinal Cord Independence Measure III (SCIM-III). Results: No serious adverse events occurred. Neither CNS tumors, abnormal cell growth, nor neurological deterioration occurred in any patients. While this initial case series was not blinded, significant functional improvements and increased quality of life (QOL) were observed at 90 and 180 days post-MSC infusion compared to pre-infusion status. One patient who had an AIS grade C improved to grade D within six months after MSC infusion. Conclusions: This case series suggests that the intravenous infusion of autologous MSCs is a safe and feasible therapeutic approach for chronic SCI patients. Furthermore, our data showed significant functional improvements and better QOL after MSC infusion in patients with chronic SCI. A blind large-scale study will be necessary to fully evaluate this possibility.
Outcomes and Healthcare Resource Utilization in Patients with COVID-19 Treated with Nirmatrelvir–Ritonavir: Real-World Data Analysis
Authors: Weil Clara , Tene Lilac , Chodick Gabriel , Fallach Noga , Ansari Wajeeha , Distelman-Menachem Tal , Maor Yasmin
Published: October 2024

Background: Nirmatrelvir–ritonavir was granted emergency use authorization in Israel in January 2022 to treat high-risk patients with mild-to-moderate COVID-19. The aim of the study was to assess the association between nirmatrelvir–ritonavir treatment and COVID-19-related hospitalization and healthcare resource utilization (HCRU) in a country with a high level of vaccinations compared to patients who were offered treatment and declined. Methods: The Maccabi Healthcare Services dataset was used to identify high-risk SARS-CoV-2-positive adults from January to February 2022 who received nirmatrelvir–ritonavir within 5 days of symptom onset (treatment group) or who were offered nirmatrelvir–ritonavir treatment and declined it (reference group). COVID-19-related hospitalizations and all-cause mortality and HCRU within 30 days were compared between treatment and reference groups using inverse probability of treatment weighting. Results: Treatment and reference groups included 3460 (median age, 68.4 years) and 1654 (70.2 years) patients, respectively. Patients with ≥1 dose of COVID-19 vaccine accounted for 89.5% (treatment group) and 72.1% (reference group) of the total. Treatment was associated with a lower risk of COVID-19-related hospitalization (adjusted OR, 0.59 [95% CI, 0.41,0.83]). Results were similar by age group (18–64/≥65 years) and among patients with/without vaccination in the prior 180 days. There were 11 (0.3%) versus 11 (0.7%) deaths in the treatment and reference groups, respectively. Treated patients had lower inpatient HCRU and greater less intensive outpatient HCRU (e.g., telemedicine and emergency room visits). Conclusions: Nirmatrelvir–ritonavir treatment was associated with a reduced risk of COVID-19-related hospitalization and a shift to less intensive outpatient HCRU. Comparison with a reference group of nirmatrelvir–ritonavir-eligible patients who declined treatment enabled an unbiased outcome assessment. Real-world data gathered during the Omicron BA.1 variant wave of COVID-19 in Israel support the continued use of nirmatrelvir–ritonavir for high-risk adults of all ages, regardless of previous vaccinations.
Pulmonary Embolism Management Audit and Machine Learning Analysis of Delayed Anticoagulation in a Swiss Teaching Hospital
Authors: Kueng Cedrine , Boesing Maria , Giezendanner Stéphanie , Leuppi Jörg Daniel , Lüthi-Corridori Giorgia
Published: October 2024

Background/Objectives: Diagnosing acute pulmonary embolism (PE) is challenging due to its wide range of symptoms and numerous differential diagnoses. Medical professionals must balance performing all essential examinations and avoiding unnecessary testing. This study aimed to retrospectively audit the diagnosis and treatment of acute PE at a Swiss public teaching hospital to determine the adherence to current guidelines and to identify the factors associated with the delayed initiation of anticoagulation in PE patients. Methods: In this retrospective observational cohort study, we included all adult patients hospitalized with PE at the Cantonal Hospital Baselland (KSBL) between November 2018 and October 2020, where the diagnosis was made within the first twelve hours of their arrival to the emergency department (ED). LASSO regression was employed to identify clinical characteristics associated with delayed anticoagulation initiation. Results: A total of 197 patients were included (mean age: 70 years, 54% female). The audit revealed that diagnostic workup was conducted according to guidelines in 57% of cases. Often, D-dimer levels were measured although not strictly necessary (70%). Pretest probability was assessed and documented using the Wells or Geneva score in only 3% of patients, and risk assessment via the Pulmonary Embolism Severity Index (PESI) score was documented in 21% of patients. The median time from ED arrival to CT scan was 120 min (IQR 89.5–210.5), and the median time to anticoagulation initiation was 193 min (IQR 145–277). Factors identified by LASSO associated with delayed anticoagulation included prolonged time from ED arrival to CT scan, the presence of distended jugular veins on examination, ED arrival in the morning, and presenting symptoms of weakness or tiredness. Complementary leg ultrasound was performed in 57% of patients, with 38% of these cases lacking prior clinical examination for deep vein thrombosis. The duration of the anticoagulation treatment was not specified in the discharge report for 17% of patients. A medical follow-up after discharge was recommended in 75% of the patients. Conclusions: In conclusion, while the management of PE at the KSBL generally adheres to high standards, there are areas for improvement, particularly in the morning performance, the use of a pretest probability assessment, D-dimer measurement, risk assessment via the PESI score, the performance of complementary leg ultrasounds, clarification of the anticoagulation duration, and follow-up management.
Fatigue Damage Monitoring of Composite Structures Based on Lamb Wave Propagation and Multi-Feature Fusion
Authors: Zhang Feiting , Zhang Kaifu , Cheng Hui , Gao Dongyue , Cai Keyi
Published: October 2024

To address the challenges associated with fatigue damage monitoring in load-bearing composite structures, we developed a method that utilizes Lamb wave propagation and partial least squares regression (PLSR) for effective monitoring. Initially, we extracted diverse characteristics from both the time and frequency domains of the Lamb wave signal to capture the essence of the damage. Subsequently, we constructed a PLSR model, leveraging Lamb wave multi-feature fusion, specifically tailored for in-service fatigue damage monitoring. The efficacy of our proposed approach in quantitatively monitoring fatigue damage was thoroughly validated through rigorous standard fatigue tests. In practical applications, our model effectively mitigated the impact of multicollinearity among feature variables on model accuracy. Furthermore, the PLSR model demonstrated superior accuracy compared to the PCR model, given an equal number of principal components. To strike a harmonious balance between efficiency and precision, we optimized the size of the feature variable. The results show that the optimized PLSR model achieved an R-squared value exceeding 97% in predicting the in-service damage area. This underscores the robustness and reliability of our method in accurately monitoring fatigue damage in load-bearing composite structures.
Pain after Licorice or Sugar-Water Gargling in Patients Recovering from Oropharyngeal Surgery—A Randomized, Double-Blind Trial
Authors: Windpassinger Marita , Prusak Michal , Gemeiner Jana , Plattner Olga , Janik Stefan , Besser Gerold , Gstoettner Wolfgang , Xuan Pu , Sessler Daniel I. , Ruetzler Kurt
Published: October 2024

Background: Glycyrrhiza glabrata (licorice) is used in traditional medicine and herbal remedies and reduces sore throats consequent to intubation, but whether it is protective for more intense pain after oropharyngeal surgery remains unclear. We thus tested the joint hypothesis that gargling with licorice, which has anti-inflammatory and antioxidant properties, reduces postoperative pain and morphine consumption. Methods: We enrolled patients having elective oropharyngeal surgery. Participants were randomly allocated to gargle with either 1 g licorice or a sugar placebo before and for up to three days after surgery. A numerical rating scale (NRS) for pain along with morphine consumption was evaluated every 30 min during the post-anesthesia care unit (PACU) stay and then three times daily for three days. We pre-specified that licorice gargling would be deemed better than sugar gargling only if found non-inferior on both morphine consumption and pain score and superior on at least one of the two. Results: 65 patients were randomized to the licorice group and 61 to placebo. We found noninferiority (NI) in pain scores with an estimated mean difference of −0.09 (95.2% CI: −0.88, 0.70; p = 0.001; NI delta = 1) between licorice and placebo gargling. There were no adverse events reported in either group that required treatment discontinuation. Conclusions: Gargling with licorice did not significantly or meaningfully reduce postoperative pain or morphine consumption in patients recovering from oropharyngeal surgery. While higher doses might prove more effective, our results suggest that other topical analgesics should be considered.
A Systematic Literature Review on Transparency in Executive Remuneration Disclosures and Their Determinants
Authors: Siwendu Tando O. , Ambe Cosmas M.
Published: October 2024

There are ongoing debates globally regarding excessive executive compensation, the perceived weak link between pay and performance, and the widening inequality gap. The South African corporate governance code King IV’s Principle 14 addresses the need for fair, responsible, and transparent remuneration. At the same time, the newly enacted Companies Amendment Act No. 16 of 2024 in South Africa emphasizes transparency in compensation, shareholder voting, and responding to shareholder feedback. This study conducts a systematic literature review of 30 articles on the transparency of executive remuneration disclosures and their determinants by analyzing Scopus-indexed articles published between 2010 and 2023, selected through specific keyword searches. The findings suggest an increasing focus on research regarding the disclosure of executive compensation, predominantly conducted in the Global North and primarily framed through agency theory. Studies exploring the factors influencing executive remuneration and the relationship between pay and performance are prevalent, with mixed results generally indicating a positive connection. Firm size emerges as a key factor in transparency, and many studies employ binary scoring to evaluate whether executive compensation disclosure is present. This paper provides valuable insights for investors, analysts, and policymakers and adds to the current understanding of executive remuneration transparency.
Glucagon, Metabolic Dysfunction-Associated Steatotic Liver Disease and Amino Acids in Humans and Animals without Diabetes Mellitus—An Evidence Map
Authors: Maruszczak Katharina , Koren Pia , Radzikowski Konrad , Pixner Thomas , Suppli Malte Palm , Wewer Albrechtsen Nicolai J. , Weghuber Daniel , Torbahn Gabriel
Published: October 2024

Introduction: Health systems are confronted with not only the growing worldwide childhood obesity epidemic but also associated comorbidities. These subsequently cause variations in distinct metabolic pathways, leading to metabolic dysfunction-associated steatotic liver disease (MASLD). The aim of this evidence map is to systematically evaluate the evidence and to identify research gaps on glucagon-induced amino acid (AA) turnover and its metabolic interaction with MASLD. Methodology: A systematic literature search was conducted up to April 2023 in three electronic databases. Studies were required to include at least two of the main research areas, glucagon, AA metabolism and MASLD. Two independent reviewers screened titles and abstracts according to prespecified eligibility criteria, as well as full-text articles. Results are summarized in tables stratified by human and animal studies and study population age. Results: Thirty-four references were ultimately included. The publication years dated back to 1965 showed a great increase from 2012 to 2023. In total, there were 19 animal studies and 15 human studies. Among the human studies, except for two studies in adolescents, all the studies were conducted in adults. In human studies, the methods used to evaluate metabolic changes differed among hyperinsulinemic-euglycemic clamp and oral glucose tolerance tests. Thirteen studies focused on the metabolic effects of MASLD, while only two studies explored the interaction between MASLD, glucagon and AA metabolism in humans. The other 19 studies focused on metabolomics, beta cell function or just one topic of a research area and not on interactions between one another. Conclusion: Research on the interaction between MASLD, glucagon and AA metabolism in humans is sparse and complete lacking in pediatrics. Furthermore, longitudinal studies with a focus on hyperglucagonemia independent of diabetes but related to MASLD present an unambiguous research gap.
Formation Mechanism and Prevention of Cu Undercut Defects in the Photoresist Stripping Process of MoNb/Cu Stacked Electrodes
Authors: Liu Dan , Fang Liang , Huang Zhonghao , Ruan Haibo , Chen Wenxiang , Xiang Jing , Wu Fang , Liu Gaobin
Published: October 2024

The Cu undercut is a recently discovered new defect generated in the wet stripping process of MoNb/Cu gate stacked electrodes for thin-film transistors (TFTs). The formation mechanism and preventive strategy of this defect were identified and investigated in this paper. The impact of stripper concentration and stripping times on the morphology and the corrosion potential (Ecorr) of Cu and MoNb were studied. It is observed that the undercut is Cu tip-deficient, not the theoretical MoNb indentation, and the undercut becomes severer with the increase in stripping times. The in-depth mechanism analysis revealed that the abnormal Cu undercut was not ascribed to the galvanic corrosion between MoNb and Cu but to the local crevice corrosion caused by the corrosive medium intruding along the MoNb/Cu interface. Based on this newly found knowledge, three possible prevention schemes (MoNiTi (abbreviated as Mo technology development (MTD) layer/Cu), MoNb/Cu/MTD, and MoNb/Cu/MoNb) were proposed. The experimental validation shows that the Cu undercut can only be completely eliminated in the MoNb/Cu/MTD triple-stacked structure with the top MTD layer as a sacrificial anode. This work provides an effective and economical method to avoid the Cu undercut defect. The obtained results can help ensure TFT yield and improve the performance of TFT devices.
Optimizing the Pore Structure of Lotus-Type Porous Copper Fabricated by Continuous Casting
Authors: Shin Byung-Sue , Hyun Soong-Keun
Published: October 2024

Lotus-type porous copper was fabricated using a continuous casting method in pressurized hydrogen and nitrogen gas atmospheres. This study evaluates the effects of process parameters, such as the hydrogen ratio, total pressure, and transference velocity, on the resulting pore structure. A continuous casting process was developed to facilitate the mass production of lotus-type porous copper. To achieve the desired porosity and pore diameter for large-scale manufacturing, a systematic evaluation of the influence of each process parameter was conducted. Lotus-type porous copper was produced within a hydrogen ratio range of 25–50%, a transference velocity range of 30–90 mm∙min−1, and a total pressure range of 0.2–0.4 MPa. As a result, the porosity ranged from 36% to 55% and the pore size varied from 300 to 1500 µm, demonstrating a wide range of porosities and pore sizes. Through process optimization, it is possible to control the porosity and pore size. The hydrogen ratio and total pressure were found to primarily affect porosity, whereas the hydrogen ratio, transference velocity, and total pressure significantly influenced pore diameter. When considering these parameters together, porosity was most influenced by the hydrogen ratio, whereas the total pressure and transference velocity had a greater influence on pore diameter. Reducing the hydrogen ratio and increasing the transference velocity and total pressure reduced the pore diameter and porosity. This optimization of the continuous casting process enables the control of porosity and pore diameter, facilitating the production of lotus-type porous copper with the desired pore structures.
Potentiometric Electronic Tongue for the Evaluation of Multiple-Unit Pellet Sprinkle Formulations of Rosuvastatin Calcium
Authors: Ciosek-Skibińska Patrycja , Cal Krzysztof , Zakowiecki Daniel , Lenik Joanna
Published: October 2024

Sprinkle formulations represent an interesting genre of medicinal products. A frequent problem, however, is the need to mask the unpleasant taste of these drug substances. In the present work, we propose the use of a novel sensor array based on solid-state ion-selective electrodes to evaluate the taste-masking efficiency of rosuvastatin (ROS) sprinkle formulations. Eight Multiple Unit Pellet Systems (MUPSs) were analyzed at two different doses (API_50) and (API_10), as well as pure Active Pharmaceutical Ingredient (API) as a bitter standard. Calcium phosphate-based starter pellets were coated with the mixture containing rosuvastatin. Some of them were additionally coated with hydroxypropyl methylcellulose, which was intended to separate the bitter substance and prevent it from coming into contact with the taste buds. The sensor array consisted of 16 prepared sensors with a polymer membrane that had a different selectivity towards rosuvastatin calcium. The main analytical parameters (sensitivity, selectivity, response time, pH dependence of potential, drift of potential, lifetime) of the constructed ion-selective electrodes sensitive for rosuvastatin were determined. The signals from the sensors array recorded during the experiments were processed using Principal Component Analysis (PCA). The results obtained, i.e., the chemical images of the pharmaceutical samples, indicated that the electronic tongue composed of the developed solid-state electrodes provided respective attributes as sensor signals, enabling both of various kinds of ROS pellets to be distinguished and their similarity to ROS bitterness standards to be tested.
Effect of Ultrasound on Microstructure and Properties of Aluminum–Copper Friction Stir Lap Welding
Authors: Zhao Wenzhen , Zhu Yalong , Liu Zhaoxian , Yi Xiaoyang , Wang Jian , Fu Ao , Wang Fengyi , He Huan
Published: October 2024

In this paper, the influence mechanism of ultrasound on plastic flow and microstructure features of the aluminum–copper friction stir lap welding (Al/Cu-FSLW) process is systematically investigated by adjusting the welding speed and improving the shear rheology in the plastic stirring zone. Through adjusting the ultrasonic vibration and welding speed, the directional control of mechanical properties is realized. It is found that increasing the welding speed properly is beneficial to enhance the mechanical shear between the tool and the workpiece, thus forming more staggered layered structures at the copper side and improving the tensile strength of the weld. The acoustic softening enhances the viscoplastic fluid mixing and strengthens the mechanical interlock of the Al/Cu lap interface. As the welding speeds increase or ultrasonic vibration is applied, the thickness of Al/Cu intermetallic compound (IMC) decreases, and the tensile strength and elongation of the Al/Cu joints are enhanced. Compared with adjusting the welding speed, the ultrasonic vibration can further refine the copper particles which are stirred into the plastic zone, and the thinning effect of ultrasound on IMC layers is better than that of increasing welding speed. At the welding speed of 60 mm/min, the IMC layer thickness is reduced by 42% under ultrasonic effect. In three welding speed conditions, the UV reduced the absolute value of the effective heat of formation (EHF) for Al2Cu and Al4Cu9 and suppressed the formation of AlCu phase. Meanwhile, only when the welding speed is increased from 60 mm/min to 100 mm/min can the formation of AlCu be suppressed. Under the ultrasonic optimization, the stable improvement of welding efficiency is ensured.
Formability Characterization Using Curvature and Strain-Rate-Based Limit Strain Detection Methods Applied to Marciniak, Nakazima, and Stretch-Bend Tests
Authors: DiCecco Sante , Cheong Kenneth , Khameneh Farinaz , Deng Zhi , Worswick Michael , Butcher Cliff
Published: October 2024

Despite advancements in the characterization of forming limit curves (FLCs) with the development of stereoscopic digital image correlation (DIC), there is still uncertainty in the accuracy of the limit strains, especially in forming operations with out-of-plane bending. The ISO12004-2:2008 standard offers a standardized approach to FLC determination but is not without limitations and is not always applicable to new materials and forming processes (e.g., warm forming, hot stamping). In the present work, a physically based limit strain detection technique is developed, termed the Enhanced Curvature Method (ECM), based on the sheet surface curvature evolution at the onset of necking in sheet formability testing. The ECM is applied to the characterization of 1.1 mm AA5182-O sheet using Marciniak, Nakazima, and stretch–bend characterization tests, and its limit strains are compared with those from the linear best-fit (LBF) local strain-rate approach and the ISO-12004 standard. The ECM considers the physical nature of necking in sheet forming with the aid of thresholds defined in terms of an imperfection metric analogous to the well-known Marciniak–Kuczynski (MK) imperfection factor. By quantifying the evolution of necking, FLCs of different safety margins can be readily generated, enabling a more intuitive selection for the factor of safety. For lower and upper ECM thresholds, the Marciniak plane strain limiting strain was determined to lie between 0.173 and 0.198, respectively, which is comparable to the analytical prediction of 0.194 and in general agreement with the published literature for AA5182-O. Similar plane strain limits were obtained using the ISO and LBF methods with values of 0.188 and 0.208, respectively. The same rankings in limit strain values between methods were observed for plane strain loading in Nakazima and stretch–bend tests.
Effect of La on Microstructure, Mechanical Properties and Friction Behavior of In Situ Synthesized TiB2/6061 Composites
Authors: Jia Jing , Zhuang Weibin , Li Jinghui , Cao Qing , Liu Jingfu
Published: October 2024

In situ synthesized 3 wt.%TiB2/6061 composites with different La contents were fabricated by an Al-K2TiF6-KBF4 system at 850 °C with ball milling and stirring casting. The effects of La content (0 wt.%, 0.1 wt.%, 0.3 wt.%, 0.5 wt.%) on the microstructures and mechanical properties of the composites at room temperature were investigated. The results showed that the addition of La could refine α-Al grains and modify the morphology of TiB2 particles significantly. In 0.3 wt.%La-3 wt.%TiB2/6061 composites, there are chamfering planes on the surface of TiB2 particles, which are caused by the adsorption of La on the {112¯0}, {12¯12} and {101¯1} crystal planes. The values of YS, UTS and EL of the composites with 0.3 wt.% La were 216.8 MPa, 273.0 MPa and 11.2%, which were 69.2%, 34.8% and 5.7% higher than those of the 3 wt.%TiB2/6061 composites. The improvement of mechanical properties was mainly attributed to the grain refinement, distributed particles and transformation of particle morphology. In friction behavior, 0.3 wt.%La-3 wt.%TiB2/6061 composites have the best wear resistance properties with the smallest and shallowest grooves on the surface after wearing. The main mechanisms of the composites are adhesive wear and abrasive wear. In summary, the best content of La addition in 3 wt.%TiB2/6061 composites is 0.3 wt.%.
Recent Advances in Metabolomics and Lipidomics Studies in Human and Animal Models of Multiple Sclerosis
Authors: Pousinis Petros , Begou Olga , Boziki Marina Kleopatra , Grigoriadis Nikolaos , Theodoridis Georgios , Gika Helen
Published: October 2024

Multiple sclerosis (MS) is a neurodegenerative and inflammatory disease of the central nervous system (CNS) that leads to a loss of myelin. There are three main types of MS: relapsing-remitting MS (RRMS) and primary and secondary progressive disease (PPMS, SPMS). The differentiation in the pathogenesis of these two latter courses is still unclear. The underlying mechanisms of MS are yet to be elucidated, and the treatment relies on immune-modifying agents. Recently, lipidomics and metabolomics studies using human biofluids, mainly plasma and cerebrospinal fluid (CSF), have suggested an important role of lipids and metabolites in the pathophysiology of MS. In this review, the results from studies on metabolomics and lipidomics analyses performed on biological samples of MS patients and MS-like animal models are presented and analyzed. Based on the collected findings, the biochemical pathways in human and animal cohorts involved were investigated and biological mechanisms and the potential role they have in MS are discussed. Limitations and challenges of metabolomics and lipidomics approaches are presented while concluding that metabolomics and lipidomics may provide a more holistic approach and provide biomarkers for early diagnosis of MS disease.
Detection and Validation of Organic Metabolites in Urine for Clear Cell Renal Cell Carcinoma Diagnosis
Authors: Holbrook Kiana L. , Quaye George E. , Noriega Landa Elizabeth , Su Xiaogang , Gao Qin , Williams Heinric , Young Ryan , Badmos Sabur , Habib Ahsan , Chacon Angelica A. , Lee Wen-Yee
Published: October 2024

Background: Clear cell renal cell carcinoma (ccRCC) comprises the majority, approximately 70–80%, of renal cancer cases and often remains asymptomatic until incidentally detected during unrelated abdominal imaging or at advanced stages. Currently, standardized screening tests for renal cancer are lacking, which presents challenges in disease management and improving patient outcomes. This study aimed to identify ccRCC-specific volatile organic compounds (VOCs) in the urine of ccRCC-positive patients and develop a urinary VOC-based diagnostic model. Methods: This study involved 233 pretreatment ccRCC patients and 43 healthy individuals. VOC analysis utilized stir-bar sorptive extraction coupled with thermal desorption gas chromatography/mass spectrometry (SBSE-TD-GC/MS). A ccRCC diagnostic model was established via logistic regression, trained on 163 ccRCC cases versus 31 controls, and validated with 70 ccRCC cases versus 12 controls, resulting in a ccRCC diagnostic model involving 24 VOC markers. Results: The findings demonstrated promising diagnostic efficacy, with an Area Under the Curve (AUC) of 0.94, 86% sensitivity, and 92% specificity. Conclusions: This study highlights the feasibility of using urine as a reliable biospecimen for identifying VOC biomarkers in ccRCC. While further validation in larger cohorts is necessary, this study’s capability to differentiate between ccRCC and control groups, despite sample size limitations, holds significant promise.
Quasi-Optical Four-Port Acoustic Filters Based on NEMS Coupled Beam Arrays
Authors: Syms Richard
Published: October 2024

Theoretical models are presented for quasi-optical four-port acoustic devices based on NEMS-coupled beam arrays. Analogies with coupled mode devices in microwaves, ultrasonics, optics, and electron wave optics are first reviewed, together with coupled beam filters. Power transfer between two mechanically coupled, electrostatically driven, coupled beam arrays is then demonstrated using a lumped element model, and the conditions for full power transfer are established. Four-port devices, including directional couplers and coupler filters with complementary transmission ports, are then demonstrated. Predictions are verified for realistic device layouts using the stiffness matrix method.
Source of Ore-Forming Fluids and Ore Genesis of the Batailing Au Deposit, Central Jilin Province, Northeast China: Constraints from Fluid Inclusions and H-O-C-S-Pb Isotopes
Authors: Li Haoming , Wang Keyong , Yan Xiangjin , Zhao Qingying , Sun Lixue
Published: October 2024

The Batailing Au deposit is a vein-type deposit in central Jilin Province, situated in the southern sector of the Lesser Xing’an–Zhangguangcai Range within the eastern Central Asian Orogenic Belt. NE-trending fault-controlled orebodies occur in the Upper Permian Yangjiagou Formation and quartz diorite–porphyrite. The mineralisation process was delineated into three stages: (I) quartz–arsenopyrite–pyrite, (II) quartz–polymetallic sulphides (main Au mineralisation stage), and (III) quartz–pyrite–carbonate. Fluid inclusions (FIs) in quartz were identified as four types: PC-type (pure CO2), C1-type (CO2-bearing), C2-type (CO2-rich), and W-type (aqueous two-phase). Raman spectroscopy analysis revealed that the vapor components of the FIs predominantly comprised CO2 with minor quantities of CH4 in stages I–II. Stages I and II encompassed four types of FIs with homogenisation temperature ranging from 264 to 332 °C and 213 to 292 °C and salinity spanning from 4.7 to 11.2 wt% and 1.8 to 11.6 wt%, respectively. Stage III exclusively contained W-type FIs with homogenisation temperature ranging from 152 to 215 °C and salinity spanning from 1.4 to 6.4 wt%. H-O isotopic values (δD = −84 to −79.6‰, δ18OH2O = 6.2 to 6.4‰ in stage I and δD = −96.4 to −90.4‰, δ18OH2O = 2.8 to 4.4‰ in stage II) and microthermometric data indicated that the ore-forming fluids are initially from a magmatic source, with later meteoric water input. Low C isotopic data from CO2 in FIs in quartz (−24.4 to −24.3‰ in stage I and −23.7 to −22.6‰ in stage II) indicated an organic carbon source. Ore precipitation is mainly attributable to fluid immiscibility. S-Pb isotopic data (δ34S = −3.5 to −1.6‰; 206Pb/204Pb = 18.325–18.362, 207Pb/204Pb = 15.523–5.562, 208Pb/204Pb = 38.064–38.221) revealed that ore metals primarily originated from magma. Based on this research, the origin of the Batailing Au deposit is of the mesothermal magmatic–hydrothermal lode type.
Nanosized Eu3+-Doped NaY9Si6O26 Oxyapatite Phosphor: A Comprehensive Insight into Its Hydrothermal Synthesis and Structural, Morphological, Electronic, and Optical Properties
Authors: Ivanovici Madalina , Ćirić Aleksandar , Periša Jovana , Marinović Cincović Milena , Brik Mikhail G. , Alodhayb Abdullah N. , Antić Željka , Dramićanin Miroslav D.
Published: October 2024

Detailed analysis covered the optical and structural properties of Eu3+-doped NaY9Si6O26 oxyapatite phosphors, which were obtained via hydrothermal synthesis. X-ray diffraction patterns of NaY9Si6O26:xEu3+ (x = 0, 1, 5, 7, 10 mol% Eu3+) samples proved a single-phase hexagonal structure (P63/m (176) space group). Differential thermal analysis showed an exothermic peak at 995 °C attributed to the amorphous to crystalline transformation of NaY9Si6O26. Electron microscopy showed agglomerates composed of round-shaped nanoparticles ~53 nm in size. Room temperature photoluminescent emission spectra consisted of emission bands in the visible spectral region corresponding to 5D0 → 7FJ (J = 0, 1, 2, 3, 4) f-f transitions of Eu3+. Lifetime measurements showed that the Eu3+ concentration had no substantial effect on the rather long 5D0-level lifetime. The Eu3+ energy levels in the structure were determined using room-temperature excitation/emission spectra. Using the 7F1 manifold, the Nv-crystal field strength parameter was calculated to be 1442.65 cm−1. Structural, electronic, and optical properties were calculated to determine the band gap value, density of states, and index of refraction. The calculated direct band gap value was 4.665 eV (local density approximation) and 3.765 eV (general gradient approximation). Finally, the complete Judd–Ofelt analysis performed on all samples confirmed the experimental findings.
Size-Sorted Superheated Nanodroplets for Dosimetry and Range Verification of Carbon-Ion Radiotherapy
Authors: Toumia Yosra , Pullia Marco , Domenici Fabio , Mereghetti Alessio , Savazzi Simone , Ferrarini Michele , Facoetti Angelica , Paradossi Gaio
Published: October 2024

Nanodroplets have demonstrated potential for the range detection of hadron radiotherapies. Our formulation uses superheated perfluorobutane (C4F10) stabilized by a poly(vinyl-alcohol) shell. High-LET (linear energy transfer) particles vaporize the nanodroplets into echogenic microbubbles. Tailored ultrasound imaging translates the generated echo-contrast into a dose distribution map, enabling beam range retrieval. This work evaluates the response of size-sorted nanodroplets to carbon-ion radiation. We studied how thesize of nanodroplets affects their sensitivity at various beam-doses and energies, as a function of concentration and shell cross-linking. First, we show the physicochemical characterization of size-isolated nanodroplets by differential centrifugation. Then, we report on the irradiations of the nanodroplet samples in tissue-mimicking phantoms. We compared the response of large (≈900 nm) and small (≈400 nm) nanodroplets to different carbon-ions energies and evaluated their dose linearity and concentration detection thresholds by ultrasound imaging. Additionally, we verified the beam range detection accuracy for the nanodroplets samples. All nanodroplets exhibited sensitivity to carbon-ions with high range verification precision. However, smaller nanodroplets required a higher concentration sensitivity threshold. The vaporization yield depends on the carbon-ions energy and dose, which are both related to particle count/spot. These findings confirm the potential of nanodroplets for range detection, with performance depending on nanodroplets’ properties and beam parameters.
Performance Enhancement of Hole Transport Layer-Free Carbon-Based CsPbIBr2 Solar Cells through the Application of Perovskite Quantum Dots
Authors: Yu Qi , Sun Wentian , Tang Shu
Published: October 2024

CsPbIBr2, with its suitable bandgap, shows great potential as the top cell in tandem solar cells. Nonetheless, its further development is hindered by a high defect density, severe carrier recombination, and poor stability. In this study, CsPbI1.5Br1.5 quantum dots were utilized as an additive in the ethyl acetate anti-solvent, while a layer of CsPbBr3 QDs was introduced between the ETL and the CsPbIBr2 light-harvester film. The combined effect of these two QDs enhanced the nucleation, crystallization, and growth of CsPbIBr2 perovskite, yielding high-quality films characterized by an enlarged crystal size, reduced grain boundaries, and smooth surfaces. And a wider absorption range and better energy band alignment were achieved owing to the nano-size effect of QDs. These improvements led to a decreased defect density and the suppression of non-radiative recombination. Additionally, the presence of long-chain organic molecules in the QD solution promoted the formation of a hydrophobic surface, significantly enhancing the long-term stability of CsPbIBr2 PSCs. Consequently, the devices achieved a PCE of 9.20% and maintained an initial efficiency of 85% after 60 days of storage in air. Thus, this strategy proves to be an effective approach for the preparation of efficient and stable CsPbIBr2 PSCs.
Impact of the Mediterranean Diet on Athletic Performance, Muscle Strength, Body Composition, and Antioxidant Markers in Both Athletes and Non-Professional Athletes: A Systematic Review of Intervention Trials
Authors: Bianchi Ellis , Erbasan Hilal , Riso Patrizia , Perna Simone
Published: October 2024

Background: The Mediterranean Diet (MD) has gained attention for its potential benefits in enhancing athletic performance and overall health. This systematic review aims to evaluate the effects of the MD on athletic performance, strength, body composition, and metabolic markers in both athletes and non-professional athletes. Methods: The review included seven studies with a total of 116 participants, ranging from professional handball players to non-professional strength athletes. The studies assessed various aspects of athletic performance, including strength, power, endurance, and body composition. Results: The main key findings from the review showed that MD may improve muscle endurance and power, as well as anaerobic performance in CrossFit athletes, and MD was associated with enhanced strength performance, including increased vertical jump height, hand grip strength, and shuttle run performance. The results on the impact on body composition were mixed, with some studies showing improvements in fat-free mass and skeletal muscle mass, while others found no significant changes. The MD also demonstrated positive effects on several markers, such as increased plasma total antioxidant activity and decreased markers of oxidative stress and inflammation. Conclusions: In conclusion, while the MD seems to represent a viable dietary strategy for enhancing athletic performance and overall health, more rigorous studies are necessary to clarify its impact across diverse athletic populations.
A Pilot Randomized Control Trial Testing a Smartphone-Delivered Food Attention Retraining Program in Adolescent Girls with Overweight or Obesity
Authors: Parker Megan N. , Bloomer Bess F. , Stout Jeffrey D. , Byrne Meghan E. , Schvey Natasha A. , Brady Sheila M. , Chen Kong Y. , Nugent Allison C. , Turner Sara A. , Yang Shanna B. , Stojek Monika M. , Waters Andrew J. , Tanofsky-Kraff Marian , Yanovski Jack A.
Published: October 2024

Background/Objectives: Attention bias (AB) toward food is associated with obesity, but it is unclear if programs designed to reduce AB can impact adolescents’ eating behavior. We investigated whether a two-week, smartphone-delivered attention retraining (AR) program (vs a control program) altered food AB in adolescent girls with overweight. Methods: Participants completed three food-cue visual-probe trainings/day. The AR and control programs directed attention away from food stimuli during 100% and 50% of trainings, respectively. Before and after completion of the programs, girls completed a food-cue visual-probe task while undergoing magnetoencephalography (MEG), and then a laboratory test meal. Results: Sixty-eight adolescents were randomized; 58 completed post-program visits. There was minimal effect of condition on AB scores (β [95%CI] = −1.9 [−20.8, 16.9]; d = −0.06). There was a small effect of condition on energy intake (EMMcontrol = 1017 kcal, EMMAR = 1088 kcal, d = 0.29). Within the AR group, there was slightly blunted initial engagement in brain areas associated with reward response and subsequent increased goal-directed attention and action control. Conclusions: We found preliminary support for efficacy of an intensive smartphone-delivered AR program to alter neural correlates of attention processing in adolescent girls with overweight or obesity. Studies with larger sample sizes are needed to elucidate if AR trainings disrupt the link between food AB and eating behavior.