bluuebunny/crossref_metadata_2025 huggingface dataset:
Adoptie als alternatief voor abortus
Authors: Garré Patrick
Published: March 2022

Adoption as alternative for abortion

Belgium and the Netherlands legalized voluntary termination of pregnancy a few decades ago under certain conditions. In both legislations the abortion doctor must also investigate whether other possibilities exist to meet the woman’s request for help. In this contribution the author examines to what extent adoption can be a reasonable alternative to an abortion. It appears that adoption is often not considered in the abortion request, with the result that opportunities are lost for the woman, the unborn child and society to avoid a termination of pregnancy after all.
ROA, ROE, CAR, and EPS on The Stock Price of PT Bank Mandiri (Persero) Tbk with GARCH (1,1)
Authors: Elindasari Nova
Published: March 2022

This study aims to analyze the effect of  ROA, ROE,  CAR, and EPS on the stock prices at PT. Bank Mandiri (Persero) Tbk in 2010-2019. Technical analysis uses simple linear regression analysis and GARCH (1,1), hypothesis testing using the t-test parsial regression coefficient testing coefficient with a level of significance of 5% (0.05). In addition, These data is non parametric because it has multicollinearity and autocorrelation. These results indicate that only show the results of GARCH (1,1) that ROA and EPS has significant effect on stock return PT Bank Mandiri Tbk.
The Effect Cash and Inventory Turnover Return On Assets PT Industri Jamu dan Farmasi Sido Muncul Tbk
Authors: Zahra Amalina Annisa
Published: March 2022

This study aims to determine the effect of cash turnover and inventory turnover partially and simultaneously on Return on Assets at PT Industri Jamu dan Farmasi Sido Muncul Tbk. The data used in this study is in the form of the company's financial statements of PT Industri Jamu and Pharmacy Sido Muncul Tbk from 2013 to 2020. The analytical method used is a descriptive test, classical assumption test, simple and multiple linear regression, hypothesis testing, and the coefficient of determination and correlation. Based on the results of the study, it shows that cash turnover and inventory turnover partially and simultaneously have a significant effect on Return on Assets. The results of the determination coefficient test of 78.5% indicate that cash turnover and inventory turnover together contribute to Return on Assets, while 21.5% is influenced by other variables not examined by this study.
E-COMMERCE PENJUALAN KOPI GAYO (Studi Kasus : UMKM Ine Kopi di Kecamatan Bandar)
Authors: Mabrur Ilham , Saputra Mahmuda , Syahputra Hendry
Published: March 2022

E-Commerce is a flexible buying and selling system where a buyer does not need to come to a physical store to buy an item. Currently e-commerce is one of the alternative options for a business that is especially engaged in the field of processed coffee as a medium of information that facilitates interaction between sellers and buyers without limited space and time.

Coffee is one of the leading commodities in plantation subsectors in Indonesia, especially in the gayo karana highland area because it has good market opportunities at home and abroad and also has an important role in the Indonesian economy, one of which is the Ine kupi business owned by individuals who are on the main shah road, bahgie bertona village, Kec Bandar, Bener Meriah, Aceh where with the design of this sales e-commerce system can make it easier for consumers to order products on Ine Kupi as long as they are connected to the internet network, Consumers only need to register, login and place an order.
Interferente clinice in psihiatrie. Experiente diagnostice
Authors: Trifu Simona , Dragoi Ana Miruna
Published: March 2022

Cartea „Interferente clinice in psihiatrie. Experiente diagnostice” se doreste a fi o colectie de prezentari clinice, si anume un numar de 38 de exemplificari grupate in functie de categorii diagnostice majore. Astfel, este abordata perspectiva asupra anxietatii, depresia majora, riscul suicidal, tulburarea obsesiv–compulsiva, tulburarea afectiva bipolara, tulburarile psihotice acute si tranzitorii sau cele polimorfe, schizofrenia in variile sale ipostaze, tulburarea deliranta si spectrul larg al tulburarilor de personalitate. Aceasta carte este a cincea lucrare de aceasta factura a Simonei Trifu, reunind o colectie mai bogata si o paleta diagnostica mai vasta, reusind, totodata, si o structurare mai atenta si mai riguroasa a cunostintelor practice, din dorinta de a transmite generatiilor viitoare modele valide de exprimare in terminologie de clinica psihiatrica.
Experiências de médicos de família e comunidade no cuidado com a saúde de pacientes lésbicas, gays, bissexuais, travestis e transexuais
Authors: Gomes Joao Antonio Smania , Tesser Junior Zeno Carlos
Published: March 2022

Introdução: A comunidade lésbicas, gays, bissexuais, travestis e transexuais e suas particularidades associadas à saúde foram ignoradas por muitos anos. Embora a homossexualidade e a transexualidade não sejam mais consideradas doenças, ainda prevalece marginalização de muitas pessoas lésbicas, gays, bissexuais, travestis e transexuais a nível sócio-econômico-cultural e de acesso aos serviços de saúde. No que tange ao acesso à saúde, o primeiro contato do paciente Lésbicas, Gays, Bissexuais, Travestis e Transexuais dentro do sistema de saúde pode ser através do médico de família e comunidade. Objetivo: Analisar as experiências dos médicos de família e comunidade no atendimento às pessoas lésbicas, gays, bissexuais, travestis e transexuais na atenção básica da rede municipal de saúde em uma cidade no Sul do Brasil. Métodos: Desenvolveram-se dois grupos focais (13 profissionais no total), um deles constituído de seis médicos de família e comunidade autodeclarados heterossexuais e cisgêneros e outro grupo constituído de sete médicos de família e comunidade autodeclarados lésbicas, gays, bissexuais, travestis e transexuais, em julho de 2019. Resultados: Os participantes consideraram importante a temática da saúde lésbicas, gays, bissexuais, travestis e transexuais na atenção primária, embora ela tenha sido pouco explorada nos seus cursos de graduação. Relataram que as principais demandas dos pacientes lésbicas, gays, bissexuais, travestis e transexuais são as de saúde mental, violência e infecções sexualmente transmissíveis. Apontaram que possuem dificuldades em abordar questões que envolvem sexualidade e identidade de gênero em suas consultas. Conclusões: Os resultados reforçam a necessidade de os médicos de família e comunidade conhecerem especificidades da população lésbicas, gays, bissexuais, travestis e transexuais. Sugere-se que a temática da saúde da população lésbicas, gays, bissexuais, travestis e transexuais seja mais ensinada nos cursos de graduação em Medicina.
ELEMENTOS E FUNDAMENTOS PARA A CONCEPÇÃO DE UM SISTEMA DE MOBILIDADE URBANA ORIENTADO À INCLUSÃO SOCIAL
Authors: Gonzaga Ana Stéfany da Silva , Portugal Licínio da Silva , Kneib Érika Cristine
Published: March 2022

Há na literatura um crescente interesse dos pesquisadores em estudar a exclusão social e suas relações com os transportes, que envolvem conceitos complexos aos quais outros elementos intervenientes estão relacionados. Entretanto, ainda há uma ênfase aos transportes e a um tratamento fragmentado, o que aponta para a necessidade de se ampliar esse enfoque, se estendendo a todo o Sistema de Mobilidade Urbana (SMU). A partir de tal lacuna observada na literatura consultada e confirmada em uma pesquisa bibliométrica, apresenta-se uma proposta com os elementos e fundamentos que podem contribuir para a concepção de um SMU orientado à inclusão social. Tal concepção pretende contribuir para uma melhor compreensão acerca das relações entre o SMU e a inclusão social, proporcionando uma visão integrada e estratégica a ser considerada na elaboração dos Planos de Mobilidade Urbana Sustentável, algo fundamental, especialmente em contextos urbanos desiguais e com deficiências no planejamento, como verificado em países latinoamericanos.
ANÁLISE MULTITEMPORAL DO SUL DO MUNÍCIPIO DE SÃO GABRIEL DO OESTE, MATO GROSSO DO SUL, REGIÃO DAS NASCENTES DO RIO AQUIDAUANA, FRENTE AS ATIVIDADES ANTRÓPICAS E SUAS CONSEQUÊNCIAS
Authors: Oliveira Ademir Kleber Morbeck de , Pinto Jorge de Souza , Matias Rosemary , Fernandes Valtecir
Published: March 2022

No estado de Mato Grosso do Sul, mais precisamente à serra de Maracaju, apesar de sua grande extensão territorial, ainda é pouco conhecida em termos de seu uso e cobertura da terra, principalmente em áreas de nascentes de importantes rios que desaguam no Pantanal, sobretudo do rio Aquidauana. Este artigo avaliou as mudanças ocorridas na paisagem na região das nascentes do rio Aquidauana, por meio da análise do uso e ocupação da terra em um recorte temporal de trinta anos. Foram utilizadas imagens dos satélites Landsat 5 TM (1990 e 2005) e Sentinel 2a MSI (2020), para o mapeamento da evolução do uso e ocupação da terra e obtenção do índice de vegetação - NDVI (Normalized Difference Vegetation Index). Os resultados apontaram uma gradativa perda da vegetação nativa florestal (32,93% em 1990; 27,79% em 2020) e aumento das áreas de lavouras (19,15% em 1990; 29,79% em 2020). Apesar da perda de áreas florestais, os índices de NDVI permaneceram estáveis, com maiores valores nas áreas mais acidentadas da região, indicando que os remanescentes estão bem preservados.
Fasten, Lehren, Heilen
Authors: Schüppel Katharina Christa
Published: March 2022

Thomas, the travelling apostle, is an actor of the 'global Middle Ages'. What was the topicality of his model of life? Who narrates the journey to India, for whom and with what intention? Images of the Apostle Thomas' journey to India in medieval manuscripts and maps are examined.
Invasive Exotic Plant-Pollinator Interactions
Authors: Anu B.C. , Vishwakarma Ramanuj
Published: March 2022

Pollination is an imperative biological process, and the exotic plant species have a significant effect on the interaction of plant with pollinators. The exotic plant communities have the ability to cause both direct and indirect impacts on pollinators. The impact of non-native exotic plants on native pollinators can occur at a varying range of scales: starting from the flower visitors who visit flowers individually, to populations and community-level interactions (insect-flower interaction networks). As it is impractical to study every invasive plant in every ecological context, understanding appropriate individual-level trait predicting direct interactions between invasive exotic plants and native pollinators is needed.
Geopolitical and Geospatial Conflicts Affecting Cutaneous Leishmaniasis: Iraqi Cases, 2014-2015
Authors: Abdulkadim Muftin Al Zadawi Karim
Published: March 2022

In Iraq, increment of cutaneous leishmaniasis (CL) was reported, a zoonotic type caused by Leishmania major and an anthroponotic type caused by Leishmania tropica. This is attributed to environmental changes, irregular construction, increased waste, and stray dogs in the cities. Internal displacement, poverty, and malnutrition play a role in the occurrence of disease. Iraq has been exposed to wars, civil war, widespread violence, and terrorism, Internal displacement of population, unlawful housing, shortage of municipal services, and accumulation of garbage have been increasing in the cities since 2003. Reports from Iraqi MOH documented an increase in the rate of CL. Eventually, case investigation, vector, and reservoir controls were suspended. Geopolitical conflicts and geospatial health deterioration contributed to an increase in various dominant reservoir species in these areas, particularly for ZCL, and the activity of the sand flies. A sudden sharp increase in CL cases was observed during 2003–2015. In conclusion, ongoing crises exposed Iraq to deterioration, collapse, and destruction of health system infrastructure and uncontrolled urbanization, all of which can act as risk factors for Leishmaniasis.
Computational Statistics with Dummy Variables
Authors: Achmad Rinaldo Fernandes Adji , Solimun  , Nurjannah
Published: March 2022

Cluster analysis is a technique commonly used to group objects and then further analysis is carried out to obtain a model, named cluster integration. This process can be continued with various analyzes, including path analyzes, discriminant analyzes, logistics, etc. In this chapter, the author discusses the reason to use dummy variables in this type of cluster analysis. Dummy variables are the main way that categorical variables are included as predictors in modeling. With statistical models such as linear regression, one of the dummy variables needs to be excluded, otherwise the predictor variables are perfectly correlated. Thus, usually if a categorical variable can take k values, we only need k-1 dummy variables, the k-th variable being redundant, it does not bring any new information. When more dummy variables than needed are used this is known as dummy variable trapping. The advantage to use dummy variables is that they are simple to use and the decision making process is easier to manage. The novelty in this chapter is the perspective of the dummy variable technique using cluster analysis in statistical modeling. The data used in this study is an assessment of the provision of credit risk at a bank in Indonesia. All analyzes were carried out using software R.
Larch: A Promising Deciduous Conifer as an Eco-Environmental Resource
Authors: Qu Laiye , Wang Yannan , Masyagina Oxana , Kitaoka Satoshi , Fujita Saki , Kita Kazuhito , Prokushkin Anatoly , Koike Takayoshi
Published: March 2022

Larch species are widely distributed in the northern hemisphere where permafrost and seasonal frozen soil exist. This species with heterophyllous shoots has been intensively planted in northeast Asia as well as in northeast China as the principal afforestation species for restoring agricultural lands to forests from 1999. Although approximately 15 species exist in the northern hemisphere and they are easy to hybridize. Among them, Japanese larch grows the fastest and was exported to Europe as a breeding species from early 20s. Although Japanese larch is tolerant to cold, it suffered from various biological stresses. After nearly 40 years of vigorous breeding effort, hybrid larch F1 (Dahurian larch × Japanese one) was developed with simple propagation methods. With the use of free-air CO2 enriched (FACE) systems, we revealed growth responses of the F1 and its parent larches to environmental conditions. From experiments, F1 showed high responses to elevated CO2 and O3 but not so much to N loading. As future perspectives for larch plantations as an important eco-environmental resource, we expect to afforest F1 seedlings infected with ectomycorrhizae (e.g., Suillus sp.) for efficient afforestation at nutrient-poor sites and at the same time for the production of delicious mushrooms.
Fermentation as Strategy for Improving Nutritional, Functional, Technological, and Sensory Properties of Legumes
Authors: Verni Michela , Pontonio Erica , Montemurro Marco , Giuseppe Rizzello Carlo
Published: March 2022

Compared with cereals and other plant-derived food matrices, legumes can be considered as valuable sources of proteins with high biological value, dietary fibers, minerals, oligosaccharides, and phenolic compounds. Nevertheless, the presence of different antinutritional factors (ANFs) limited the large-scale use of such ingredients by the food industry. The potential of several biotechnological processes and enzymatic treatments in decreasing ANF in legumes and legume-derived ingredients was investigated. Among these options, fermentation is traditionally recognized as suitable tool to improve the overall quality of legumes in different areas of the world. The scientific community demonstrated the effectiveness of the use of selected lactic acid bacteria and biotechnologies inspired to sourdough fermentation in ANF degradation, improving technological and sensory profile of legume grains and flours as well as contributing to their safety in terms of spoilage or pathogenic microorganisms and toxic compounds. Apart from their consumption as they are, legumes are the main ingredient of many traditional food products, and fermentation allows them to be used as ingredients in innovative formulations of staple foods, such as baked goods and pasta with high nutritional and functional profile.
The Non-Cosmetic Dermatological Use of Botulinum Neurotoxin
Authors: Angelo-Khattar Maria
Published: March 2022

Botulinum neurotoxin injections are currently the most popular non-surgical cosmetic therapy for treating hyperdynamic lines and rebalancing face muscles all over the world. However, there is emerging interest in the use of the neuromodulator for the treatment of non-cosmetic clinical conditions. The present evidence supporting the use of Botulinum toxin in the treatment of acne and oily skin, rosacea, alopecia areata and androgenic alopecia, scar prevention and therapy, postherpetic neuralgia, hyperhidrosis, and disorders exacerbated by sweating is discussed in this chapter. Case reports and a few randomized controlled trials are used to support the use of Botulinum toxin in several of these illnesses. Nonetheless, the therapeutic application of Botulinum toxin in various skin conditions linked with discomfort, inflammation, and hyperhidrosis has a lot of promise.
Inoculant Formulation and Application Determine Nitrogen Availability and Water Use Efficiency in Soybean Production
Authors: E.N. Savala Canon , Chikoye David , Kyei-Boahen Stephen
Published: March 2022

Inoculation of suitable rhizobia enhances biological nitrogen fixation in soybean production and are economically viable for use among smallholder farmers due to its low price over inorganic commercial fertilizer blends. In Mozambique, inoculants are available in liquid or solid form (powder/peat or granular). Field studies were conducted in 2017 and 2018 seasons in three agroecologies (Angonia, Nampula and Ruace) in Mozambique to evaluate the performance of inoculants when applied directly to soil and on seed before planting. Data on nodulation, plant growth, nitrogen fixed, 13C isotope discrimination related water use efficiency, yield and yield components were analyzed in Statistical Analysis System® 9.4. Nodulation, yield, and yield components were significant for the different application methods, and solid form tended to be better than liquid form. The nitrogen derived from atmosphere (%Ndfa) were 45.3%, 44.2% and 43.6% with a yield of 2672, 1752 and 2246 kg ha−1 for Angonia, Nampula and Ruace, respectively. Overall, inoculants applied on soil or seed increase the amount of biologically fixed nitrogen and has the potential of improving soybean productivity in Mozambique.
Streptococcal Skin and Skin-Structure Infections
Authors: Rapose Alwyn
Published: March 2022

Infections attributable to Streptococcus are protean. These range from mild skin and soft tissue infections to life-threatening conditions like meningitis, endocarditis and toxic shock syndrome. In addition, streptococcal infection can be associated with noninfectious sequelae like rheumatic fever and post-streptococcal glomerulonephritis. There is a wide range of Streptococcus spp. causing human infections and different classifications of these organisms have been described, the most quoted being the Lancefield classification based on cell-wall antigens. Streptococci can be studied based on their species: S. pyogenes, S. pneumoniae, S. anginosus etc. or by the Lancefield classification group A, B, C, D etc. or by the clinical syndromes associated with these bacteria. This chapter will describe clinical syndromes associated with streptococcal skin and soft tissue infections ranging from mild: cellulitis and lymphangitis which can be treated in the out-patient setting, to more aggressive manifestations that require hospitalization (sepsis and toxic shock syndrome) and even surgery (necrotizing fasciitis, myositis and gangrene), It will also provide clues to clinical diagnosis as well as suggest recommendations for optimized management of these conditions.
Perspective Chapter: Lipoprotein (a), Cardiac Amyloidosis, and Aortic Stenosis - Underestimated Associations
Authors: Santangelo Gloria , Bernardi Nicola , Faggiano Andrea , Bonelli Andrea , Toriello Filippo , Faggiano Pompilio , Carugo Stefano
Published: March 2022

This chapter aims to address two peculiar aspects of pathophysiology and clinical management of aortic valve stenosis, such as coexistence with cardiac amyloidosis and association with lipoprotein (a). Calcific aortic valve stenosis is the most common heart valve condition requiring surgical or transcatheter aortic valve replacement among adults in Western societies. Lipoprotein (a) has been shown to play an important role in the pathophysiological pathways leading to degenerative aortic stenosis, similar to that in the pathogenesis of atherosclerosis. Studies are needed to verify whether therapies that drastically reduce Lipoprotein (a) serum levels offer the possibility of a first medical treatment to arrest the progression of aortic stenosis. A large percentage of patients with aortic stenosis may have concomitant cardiac amyloidosis, commonly due to wild-type transthyretin. The challenge in this context is to differentiate aortic stenosis alone from aortic stenosis with cardiac amyloidosis, as cardiac amyloidosis shares several clinical, electrocardiographic, and echocardiographic features with the aortic stenosis phenotype. Recognition of transthyretin-related amyloidosis prior to any type of intervention is crucial for adequate risk stratification and to guide downstream management.
Heidegger and Professor Capobianco
Authors: Sheehan Thomas ,   Philosophy Documentation Center
Published: March 2022

Phenomenology offers the only proper entrée to Heidegger’s work, a fact overlooked by ‘Right Heideggerians’ such as Professor Richard Capobianco, with disastrous results. This essay traces Heidegger’s path through Husserl’s doctrine of categorial intuition to his own question about what makes possible the meaningful presence of things.
Organic Intellectuals in the Prison: Reports from the Flying University on Philosophy as Public Practice
Authors: Neely Sol ,   Philosophy Documentation Center
Published: March 2022

The Flying University, a prison education and reentry program that brings university students inside the prison for mutual and collaborative study, convenes with the assumed understanding that incarcerated peoples bear rich critical perspectives on the state of our communities as well as a philosophical potential to muster the resources necessary to heal communities in the wake of historical violence and transgenerational trauma. Rather than bringing incarcerated students into the purview of academic philosophy, the Flying University reverses these roles by recognizing that incarcerated peoples engage in daily philosophical scrutiny about a whole range of topics that traditional academic philosophy too often fails to comprehend with any depth. The Flying University enacts precollege philosophy as public practice by facilitating semester-long seminars that bring professional philosophers and university students into the prison—not so they can teach prisoners but listen to them. The guiding critical assumption of this practice follows Antonio Gramsci’s argument that what distinguishes “philosophers” from their opposite has less to do with intellectual activity and perspective and more to do with social status and credentials. A genuinely restorative philosophical praxis must solicit, within our community dialogues, the stories and voices of our incarcerated neighbors as “organic intellectuals.”
Hyperspectral absorption of water around 2 μm based on a boradband tunable, narrow linewidth Tm-doped fiber laser
Authors: Tao Meng-Meng , Wang Ya-Min , Wu Hao-Long , Li Guo-Hua , Wang Sheng , Tao Bo , Ye Jing-Feng , Feng Guo-Bin , Ye Xi-Sheng , Chen Wei-Biao ,   Wang Zhijiang Laser Innovation Center, Shanghai Institute of Optics and Fine Mechanics, Chinese Academy of Sciences, Shanghai 201800, China,   State Key Laboratory of Laser Interaction with Matter, Northwest Institute of Nuclear Technology, Xi’an 710024, China
Published: March 2022

The 1.8–2.0 μm waveband contains abundant absorption lines of water, which are much stronger than those in the traditional 1.3–1.5 μm waveband, exhibiting huge potentials for absorption spectrum applications of water. In the hyperspectral absorption spectrum, physical parameters of the target molecule can be derived from lots of absorption lines within a broadband scanning range, achieving the results more robust, accurate and versatile than the results from the conventional tunable diode laser absorption spectrum in which only one or two absorption lines are used. The key to hyperspectral absorption is the development of broadband tunable, narrow linewidth laser sources emitting in the wavelength range of interest. With a tunable fiber FP filter and a fiber saturable absorber, a Tm-doped fiber laser is established, featuring broadband tenability and narrow linewidth. Taking advantage of the re-absorption characteristics of Tm-doped silica fibers, a wavelength tuning range covering 60 nm from 1910–1970 nm is obtained through the appropriately designing of the active fiber length. The measured laser linewidth at steady state is smaller than 0.1 nm, which is suitable for water absorption spectrum. Hyperspectral absorption measurements of water in air and alcohol flame are conducted. In room-temperature air, more than 40 absorption lines are recognized within a tuning range of 1910–1965 nm, while, in alcohol flame, the number of detected lines reaches about 50. Comparison with the HITRAN2016 database gives a laser linewidth of about 0.06 nm which is very close to the static linewidth measured by an OSA. The temperature of the air is derived to be 298 K with a water mole fraction of about 2%, which is consistent with the measurement of the hygrothermograph. And the calculation indicates an alcohol flame temperature of about 1220 K, which is very close to the measurement result of the thermocouple.
Structure and thermoelectric performance of AgyIn3.33–y/3Se5 compounds
Authors: Zi Peng , Bai Hui , Wang Cong , Wu Yu-Tian , Ren Pei-An , Tao Qi-Rui , Wu Jin-Song , Su Xian-Li , Tang Xin-Feng ,   State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan 430070, China,   Nanostructure Research Center, Wuhan University of Technology, Wuhan 430070, China
Published: March 2022

In this study, we find new AgyIn3.33–y/3Se5 compounds in Ag-In-Se system by static diffusion method combined with common X-ray diffraction and backscattering electron analysis. The crystal structure belongs to the trilateral system with the P3m1 space group, which features a two-dimensional layered structure. The unit cell is composed of 9-atom quantum layers arranged in the sequence of Se1-In1-Se2-In2-Se3-Ag/In3-Se4-In4-Se5, and in-between these layers are bonded by the weak van der Waals force. The sintered bulk samples show highly anisotropic transport properties and have an ultra-low lattice thermal conductivity along the direction parallel to sintering pressure about 0.15 W·m–1·K–1 at 873 K. The intrinsically ultra-low lattice thermal conductivity mainly comes from low phonon velocity and the strong coupling between low frequency optical phonon and acoustic phonons. The AgyIn3.33–y/3Se5 compounds behave as an n-type conduction. The electrical conductivity is 4×104 S·m–1 and the Seebeck coefficient is –80 μV·K–1 at room temperature. Therefore, AgyIn3.33–y/3Se5 compounds show high electrical transport properties in a wide temperature range, and the power factor is around 5 μW·cm–1·K–2 in a range of 450–800 K. Owing to the ultra-low lattice thermal conductivity along the direction parallel to sintering pressure, Ag0.407In3.198Se5 reaches a maximum ZT of 1.01 at 873 K and an average ZT of 0.45 at 300–850 K. The discovery of AgyIn3.33–y/3Se5 expands the n-type copper based chalcogenide and lays an important foundation for the application of copper based chalcogenide.
The TRRAP transcription cofactor represses interferon-stimulated genes in colorectal cancer cells
Authors: Detilleux Dylane , Raynaud Peggy , Pradet-Balade Berengere , Helmlinger Dominique
Published: March 2022

Transcription is essential for cells to respond to signaling cues and involves factors with multiple distinct activities. One such factor, TRRAP, functions as part of two large complexes, SAGA and TIP60, which have crucial roles during transcription activation. Structurally, TRRAP belongs to the phosphoinositide 3 kinase-related kinases (PIKK) family but is the only member classified as a pseudokinase. Recent studies established that a dedicated HSP90 co-chaperone, the triple T (TTT) complex, is essential for PIKK stabilization and activity. Here, using endogenous auxin-inducible degron alleles, we show that the TTT subunit TELO2 promotes TRRAP assembly into SAGA and TIP60 in human colorectal cancer cells (CRCs). Transcriptomic analysis revealed that TELO2 contributes to TRRAP regulatory roles in CRC cells, most notably of MYC target genes. Surprisingly, TELO2 and TRRAP depletion also induced the expression of type I interferon genes. Using a combination of nascent RNA, antibody-targeted chromatin profiling (CUT&RUN), ChIP, and kinetic analyses, we propose a model by which TRRAP directly represses the transcription of IRF9, which encodes a master regulator of interferon-stimulated genes. We have therefore uncovered an unexpected transcriptional repressor role for TRRAP, which we propose contributes to its tumorigenic activity.
Assembly of recombinant tau into filaments identical to those of Alzheimer’s disease and chronic traumatic encephalopathy
Authors: Lövestam Sofia , Koh Fujiet Adrian , van Knippenberg Bart , Kotecha Abhay , Murzin Alexey G , Goedert Michel , Scheres Sjors HW
Published: March 2022

Abundant filamentous inclusions of tau are characteristic of more than 20 neurodegenerative diseases that are collectively termed tauopathies. Electron cryo-microscopy (cryo-EM) structures of tau amyloid filaments from human brain revealed that distinct tau folds characterise many different diseases. A lack of laboratory-based model systems to generate these structures has hampered efforts to uncover the molecular mechanisms that underlie tauopathies. Here, we report in vitro assembly conditions with recombinant tau that replicate the structures of filaments from both Alzheimer’s disease (AD) and chronic traumatic encephalopathy (CTE), as determined by cryo-EM. Our results suggest that post-translational modifications of tau modulate filament assembly, and that previously observed additional densities in AD and CTE filaments may arise from the presence of inorganic salts, like phosphates and sodium chloride. In vitro assembly of tau into disease-relevant filaments will facilitate studies to determine their roles in different diseases, as well as the development of compounds that specifically bind to these structures or prevent their formation.
A comparative study of life skills, lifestyle habits and academic performance in health promoting and non-health promoting schools in the Autonomous Community of Aragon, Spain
Authors: Sánchez-Hernando Beatriz , Gasch-Gallén Ángel , Antón-Solanas Isabel , Gea-Caballero Vicente , Juárez-Vela Raúl , Gállego-Diéguez Javier , Carboneres-Tafaner María Inmaculada , Echániz-Serrano Emmanuel , Lasso-Olayo Laura , Santolalla-Arnedo Ivan
Published: March 2022

Background

There is insufficient evidence about the impact of health promoting schools on the student’s health and academic performance. The aim of this study was to compare the life skills, lifestyle habits and academic performance of 7th and 8th grade students registered in health promoting and non-health promoting schools in the Autonomous Community of Aragon.

Methods

An observational, descriptive, comparative study of the life skills, lifestyle habits and academic performance of 7th and 8th grade students registered in 43 randomly selected health promoting and non-health promoting schools was carried out. We used an adapted tool, which was validated through the expert panel technique, to evaluate the students’ life skills (self-efficacy, social skills and affect balance), lifestyle habits (diet, sleep, physical exercise, use of screen and substance abuse) and academic performance.

Results

The socioeconomic level of the mothers and fathers of the students who attended non-health promoting schools was significantly higher than that of the parents of the adolescents who attended health promoting schools (p < 0.001). The students who attended non-health promoting schools had better self-efficacy, led a healthier life generally and achieved better academic results (p = 0.03).

Conclusions

As opposed to previous studies, which found a positive association between health promoting schools and life skills, lifestyle habits and academic performance, our findings suggest that the impact of these health programs on the students’ health and academic performance is limited. We recommend that the degree of implementation of health promotion programs in health promoting schools is systematically evaluated, and the health promoting school accreditation process and requirements reviewed, in order to ensure that the health of school children and adolescents is safeguarded and promoted in the short, medium and long term.
A Systematic Literature Review of Meta-Learning Models for Classification Tasks
Authors: Kamiri Jackson , Mraiga Geoffrey , Oirere Aaron
Published: March 2022

Meta-learning is a field of learning that aims at addressing the challenges of conventional machine learning approaches such as learning from scratch for every new task. The main aim of this study was to do a systematic literature review of the existing meta-learning models that have been developed, published, and can be used for classification tasks. Systematic literature review method was used, employing a search of journal articles and publications of conference proceedings. The process involved data collection, analysis, and reporting of the results. To achieve the objective, 30 primary papers published since 2016 and relevant to classification tasks in meta-learning were considered. Data was extracted from the papers, then the following was analyzed in each model as presented in the papers; techniques used, the contribution, and the research gap. Although a lot has been done so far in Meta-learning, the existing models are not yet optimal. They still have challenges in few-shot learning, computation time complexity, difficulty in continual learning, and generalizability across multiple related tasks during transfer learning.
Conjunctival Myxoma: Series of 3 Cases of a Rare Ocular Tumour
Authors: Khatib Yasmeen , Pandey Vinita , Sable Yogita , Pandey Rahul , Gupte Prajakta
Published: March 2022

Conjunctival myxomas are very rare benign tumours of mesenchymal origin which pose a diagnostic challenge clinically and radiologically. They usually present as asymptomatic slowly growing cystic lesions involving the bulbar conjunctiva. Two cases were with usual presentation while one was with unusual presentation. Two cases of conjunctival myxoma (59 year old female patient and 65 years old male patient) involving the bulbar conjunctiva and one (56 years old female patient) in the palpebral conjunctiva are reported. Anterior segment examination and fundoscopy were within normal limits. A clinical diagnosis of conjunctival cyst, pinguecula and pyogenic granuloma was made in the three cases, respectively. Excision was done in all the cases and a diagnosis of myxoma was made based on the characteristic histological and immunohistochemical features. No systemic involvement was seen. The authors hereby report the present cases because of their rarity and to emphasise that, histopathology is required to distinguish it from other conjunctival lesions.
Assessment of the Microbiological Status of Yoghurt Sold in Owerri, Imo State, Nigeria
Authors: Dike-Ndudim Joy Nkeiruka , Nnadiobi Chidinma , Ndubueze Chizaram Winners , Chinecherem Ndudim Victor
Published: March 2022

The assessment of the microbiological status of samples of yoghurt sold in Owerri, Imo state, Nigeria, was carried out to ascertain the microbiological fitness of the yoghurt samples for consumption. The yoghurt samples were collected from areas spanning three local governments in Owerri. Ten samples of commercial brands of yoghurt drinks was collected and analyzed bacteriologically by pour plate method using Nutrient Agar for heterotrophic bacteria, MacConkey Agar for total coliform and MacConkey Broth for fecal and thermo-tolerant coliform bacteria by Most Probable Number (MPN) technique and mycologically on Sabouraud dextrose Agar for fungi. Data from analysis were analyzed using ANOVA. Determination of the pH of the yoghurt samples was done and the results showed that the pH values ranged from 4.28 to 4.79. the results of the total heterotrophic bacteria count were from 5.07.1bc to 9.07.1a×105CFU/ml, while the total coliform bacteria ranged from 1.70.5ab to 3.61.2ab×104CFU/ml and the thermo-tolerant coliform bacteria ranged from 11 to 120(MPN) 100-1. The total fungal count ranged from 2.91.6b to 10.33.6a×104CFU/ml. The pH determination revealed that the isolates are acidophile because the pH of the yoghurt samples were in the acidic range. There was a significant difference at P >0.05 and the difference were separated using the least significant difference (LSD).  Five bacterial isolates were identified included: Staphylococcus aureus, Escherichia coli, Streptococcus spp., Lactobacillus bulgaricus and Serratia marcesecens. The fungal genera identified were Candida albicans, Aspergillus niger, Mucor spp. and Saccharomyces cerevisiae. The isolation of both fungal and bacterial organisms known to be enteric pathogens is suggestive of  faecal contamination and by implication a serious public health problem due to the health hazards they pose to consumers. The result of this study therefore indicated poor Microbiological qualities of commercial yoghurts sold in Owerri at the time of this research. Therefore, the attention of the appropriate government agencies is needed to ensure that adequate hygiene is maintained during preparation, processing, storage and distribution of high quality yoghurt products to avert public health challenges.
Reduction of Harmonics in Power Lines Using Finite Impulse Response Filter
Authors: Atuchukwu A. J. , Uju I. U. , Ugwu Efoke, Matthew
Published: March 2022

This work focused on reduction of harmonics in Power lines using finite impulse response filter. Since the rising usage of power electronic devices sensitive to harmonics, which has resulted in a growth in the number of adverse harmonic-related occurrences, network harmonic investigations have become a major concern in electric power systems. The problem of power quality and how to control it is becoming more of a concern. Power quality difficulties have arisen as a result of the connection of nonlinear loads in the network, resulting in widespread waveform distortion. The harmonic analysis was based on bus bar voltage solutions acquired from a power flow study on the Electricity Distribution Company's power distribution network at the Onitsha TCN work centre. The focus of this work was on the use of active power filter in reducing the harmonics by generating compensation signal by the active filter (APF) for the reduction of harmonic distortion as well as enhancing the system’s power factor. A system model to reduce harmonics in power line by using FIR filter to generate compensation signals and switching pulses for the active filter was modeled and the performance of the FIR filter using Matlab/Simulink environment was compared with the performance without filter. The sending and receiving end bus bar voltages were derived from the power flow analysis and used in the simulation. Harmonic results without filter and with filter were shown and it shows that the use of FIR active filter which has improved advantages over the conventional passive filters in mitigating harmonics was able to reduce the harmonics from 17.77% to 0.87% which is 16.9% ( 95% reduction) thereby improving the current, voltage and power factor (pf) of the system. Reduction of harmonics reduced disturbances that usually cause equipment overheating and deterioration of the performance of electronic equipment; hence the performances of the electronic equipment greatly improved leading to economic benefits.
Airway Management: A Case of Desmoplastic Ameloblastoma of Right Mandibular Body
Authors: Bhuyan Deepjit , Chandak Aruna V. , Chandak Vijay , Ninave Dr.Sanjot , Verma Neeta
Published: March 2022

Background- Desmoplastic ameloblastoma (DA) is an uncommon variety of ameloblastoma that accounts for 4–13% of all cases, with notable differences in anatomical location, imaging, and histologic appearance. It is classified as a variety of ameloblastoma in the WHO classification of head and neck tumours (WHO-2005). Because it commonly occurs in the anterior region of the jaws as a mixed radio-opaque-radiolucent lesion, the tumour resembles a benign fibro-osseous lesion.

Case report- We present a case of desmoplastic ameloblastoma in a 51-year-old female with a painless swelling in the lower right region of mandible. Fine needle aspiration revealed no fluid. Both panoramic radiographs and a computed tomography scan revealed a mixed lesion with a multilocular appearance. Desmoplastic ameloblastoma was confirmed after an incisional biopsy. From teeth 41 to the angle of the jaw, a composite resection of the lesion was performed with segmental mandibulectomy. With a peek implant, it was repaired. The possibility for a problematic airway is emphasised in this case, with great surgical results.

Conclusion: Desmoplastic ameloblastoma is a kind of ameloblastoma with unique clinic radiographic and histologic characteristics. Despite its rarity, the tumour necessitates a thorough examination due to the challenges it poses with airway ventilation and intubation.
Comparing Spot Urine Protein: Creatinine Ratio 24-Hour Urinary Protein Estimation in Type 2 Diabetes Mellitus Patients
Authors: Nazia Shafaq , Shaikh Farazul Haque , Ameer Nasrullah , Abbasi Anwar Hussain , Razzaq Atiya , Ahsan Maryam , Atique Anum
Published: March 2022

Background & Objective: A simple blood test (urea and creatinine) and a urine test may indicate renal function deterioration and presence of microalbuminuria, which is also the first clinical signs of renal dysfunction in patients with diabetes mellitus. This cost effective test easy to perform even in the absence of advance facilities in a hospital. That is why we planned to conducted this study to assess the comparison between of spot urine protein:creatinine ratio with 24-hour urinary protein in patients with type 2 diabetes mellitus.

Materials and Methods: This prospective hospital based clinical study was conducted in the Department of General Medicine, Liaquat University of Medical & Health Sciences, Jamshoro, over a period of six months from 10th May 2018 to 9th November 2019 through a consecutive sampling technique. All the patients having age more than 18 years of both gender, and type 2 diabetes mellitus were enrolled in this study. Three cc blood was taken to determine the serum creatinine levels and twenty-four hour 2ml urine sample was also collected to determine the urinary protein levels. The proteinuria ≥300mg/dl in 24-hour urine sample was considered as significant proteinuria. Kappa statistics was used to find agreement between spot urine protein and 24 hours urinary protein.

Results: A total 95 patients were evaluated and their mean age was 41.91±14.29 years, with male predominance (n = 66, 69.4%). Average 24 hour urinary protein was 1216.99±949.51mg and spot-urine evaluation of protein was 1919.12±2129.25mg. The agreement between spot urinary protein creatinine ratio and 24 hour urinary protein was found in 82.1% of cases through Kappa statistics and the calculated agreement between the two procedures was 0.975 which provides sufficient agreement to use spot urine protein:creatinine ratio in routine diagnosis of proteinuria.

Conclusion: The study have shown that the protein:creatinine ratio for a random urine sample might be used to rule out the presence of significant proteinuria as defined by a quantitative measure of the 24-hour urine protein excretion.
Trans-fistula Anorectoplasty (TFARP) in the Management of Anorectal Malformation (ARM) with Recto Vestibular Fistula (RVF) in Females: A Retrospective Study
Authors: Qureshi Mumtaz Ahmed , Sumaira . , Khokhar Iqra Rafique , Aslam Iqra , Larik Sobia , Chohan Muhammad Nadeem
Published: March 2022

Aim: To determine the outcome of trans-fistula anorectoplasty (TFARP) in female children having anorectal malformation with recto-vestibular fistula.

Study Design: A retrospective study.

Place and Duration: Department of pediatric surgery during the period of February 2018 to February 2020.

Methodology: A total of 87 female children who have imperforate anus with recto-vestibular fistula from the age of 3 months to 6 years were included in this study. Initially, we have started this technique with the covering sigmoid colostomy, then TFARP after 12 weeks interval & once new anus healed and hegar dilatation achieved then sigmoid colostomy closed after 24 weeks of the first procedure. When we were experienced then we start TFARP as a single-stage procedure. Post-operative data regarding early complications of local wound infections, prolapse of the rectal mucosa, and late complications for anal stenosis, rectal prolapse, and scarring in the perineal body were collected up to 2-3 months respectively.

Results: A total of 87 patients were included in this study. The average operative time was 40 minutes. The total days of hospital stay were 3 to 5 days. Regarding early complications, skin excoriation was present in 21 (24%) followed by vaginal tear in 17 (19%) cases. Mucosal prolapse was a late complication observed in 17 (20%) cases. Continence was good (Score 0) in 33 (38%) cases, while it was fair (score 1) in 36 (41%) cases.

Conclusion: Primary repair of recto-vestibular fistula by Trans-fistula anorectoplasty in children is a feasible procedure that has a good cosmetic appearance and anal continence. Single-stage reconstruction is possible in children with satisfactory results. It produces less morbidity and is a more efficient procedure.
The Impact of Bariatric Surgery on the Pharmacokinetic Behaviors of Orally Administered Drugs
Authors: Ahmed Ahmed , Heyam Ali S. , Elhassan Gamal O. , Abdelhameed Hifny , Alhoufie Sari T. S. , Alqahtani Saad S. , Alfarouk Khalid O.
Published: March 2022

Bariatric surgery is considered an appropriate method in cases of obesity, such as severe or comorbidities obesity. However, the number of patients requiring bariatric surgery is growing  constantly and rapidly. Opposing that, the anatomical modifications of the gastrointestinal tract often lead to a significant alteration in the pharmacokinetics of orally administered drugs in terms of absorption of drugs and the bioavailability of oral medications required after the surgery. The current study investigates the correlation between reduced body mass following bariatric surgery and the bioavailability of orally administered drugs. Therefore, it is required to warrant through clinical studies that help establish guidelines related to common oral drugs prescribed and monitor the medications that exhibit a small therapeutic window that should be assessed, excluding the clinical endpoint. Furthermore, the use of pharmacokinetic modeling based on a mechanical method to simulate the multivariate nature observed while changes occur during the exposure of drugs will help to serve as an essential tool to understand further the trends in oral exposure of drugs in postoperative cases develop practical clinical guidance.