bluuebunny/crossref_metadata_2025 huggingface dataset:
FORMULATION AND IN VIVO EVALUATION OF PEMIGATINIB SUPER SATURABLE SELF-NANO EMULSIFYING DRUG DELIVERY SYSTEM
Authors: REDDY MUTHADI RADHIKA , GUBBIYAPPA SHIVA KUMAR
Published: November 2023

Objective: Pemigatinib is an active component in treatment of cholangiocarcinoma, but the low solubility and bioavailability of Pemigatinib limit its wide application. The aim of the present study was to prepare and evaluate supersaturable self-nanoemulsifying drug delivery systems (sSNEDDS) followed by investigating and comparing the pharmacokinetic profiles of Pemigatinib and Pemigatinib sSNEDDS in rat plasma by HPLC.
Methods: Pemigatinib loaded SNEDDS were obtained by dissolving drug in the isotropic mixture of oil, surfactant, and co-surfactant. The conventional SNEDDS were converted to sSNEDDS by precipitation method by using an experimented polymer. An appropriate high sensitivity and selectivity was applied to the comparison of plasma pharmacokinetics in Pemigatinib and Pemigatinib sSNEDDS using Entrectinib as an internal standard (IS).
Results: The droplet of sSNEDDS ranges from 166.78±3.14 to 178.86±1.24 nm with PDI 0.212–0.256, transmission electron microscopy images revealed the spherical shape of the nanodroplets, emulsification time was 15 secs when added to physiological fluids, percent transmittance of the diluted formulation was 99.12±0.46, and viscosity was 574±26 centipoises indicating the good flow ability. FTIR and DSC studies indicated the amorphization of the drug. The dissolution profile of sSNEDDS indicated the faster release of drug compared to both pure drug suspension and SNEDDS formulation. Cmax of the sSNEDDS 3.52±0.13ng/ml was significant (P<0.05) as compared to the pure drug suspension formulation 2.82±0.42 ng/ml. The AUC0-t, AUC0–∞ of sSNEDDS was increased, while the Tmax and t1/2 was decreased. Moreover, the AUC value in the sSNEDDS group was significantly increased and the relative bioavailability was calculated to be 69% when compared with that of the Pemigatinib group.
Conclusion: These results concluded that Pemigatinib sSNEDDS when compared with pure drug after a single oral administration and the formulation modification of Pemigatinib into sSNEDDS can effectively enhance gastrointestinal absorption and relative bioavailability by improving solubility and dissolution rate.
AN OVERVIEW OF DISCRETE NANOFORMULATED FLAVONOIDS AND ITS IMPLICATION IN CANCER
Authors: M. LAVANYA , PADMINI RAMAKRISHNAN
Published: November 2023

The nanoformulation of phytochemical has been developed to withdraw the drawbacks of conventional phytochemical. Nanoformulations are the nanosized particles, modified in order to improve the delivery of active phytochemicals in the target, to improve bioavailability, and solubility. Early researches shows that various phytochemicals like curcumin, Hesperidin, resveratrol, ellagic acid, essential oil, Naringenin, and quercitin are highly modified to form the nanoformulated compounds to improve its bio-activities. The nanoformulated phytochemicals are syntheized by various methods such as high energy and low energy emulsification, electrostatic stabilization, emulsification/reverse salting-out, nanoprecipitation, emulsification/solvent diffusion, solvent evaporation, and multi-arm Nanoconjugates, enzyme responsive nanoconjugates, core-crosslinked nanoconjugate hydrophobic–hydrophilic nanoconjugates, and nanoconjugate-based solid dispersion. Interestingly, the encapsulation of phytochemicals with surfactants, oils, emulsifying agents, salting-out agents will promote the antioxidant, antitumor, cytotoxic agents and antimicrobial effects than a raw phytochemicals. Various studies showed that phytochemicals are nanoformulated by the nanoemulsion method are better in terms of active target drug delivery, increasing bioavailability and it also act as an effective biological and diagnosting agents. This review focus on Innovative approaches to nanoformulated phytochemicals and their biomedical applications.
IN VITRO AND IN VIVO EVALUATION OF EZETIMIBE FAST-DISSOLVING FILMS
Authors: AKASH V. , SHAILAJA P.
Published: November 2023

Objective: The goal of this investigation was to develop and evaluate Ezetimibe fast-dissolving films, which are used to treat hyperlipidemia and prevent cholesterol absorption.
Methods: The fast-dissolving Ezetimibe films were developed using the solvent casting method and included the following ingredients sodium carboxy methyl cellulose, HPMC E5, Polyvinyl Alcohol, Polyvinyl pyrrolidone which act as film-forming agents polyethylene glycol 600 and sodium starch glycolate, which acts as a superdisintegrant and plasticizer;, citric acid and stevia powder, which serves as a saliva stimulant and sweetener.
Results: The fast-dissolving films of Ezetimibe prepared with PVP K30 released the drug up to 99.87% within 5 min, which showed the increased solubility, dissolution rate, flexibility and tensile strength of the films when compared to formulation prepared with sodium carboxy methyl cellulose, HPMC E5, Polyvinyl Alcohol. The FTIR and DSC studies were conducted for pure drug, polymers and optimized formulation E11, which indicated that were no incompatibilities found between the drug and polymers used in the present studies. Scanning electron microscopy analysis was performed for pure drug, and optimized formulation E11 showed that they were no surface fractures and cracks in the films. The optimized formulation E11 was subjected to in vivo studies by using New Zealand Rabbits, and accelerated stability studies revealed that all the formulation is stable.
Conclusion: The current study reveals that fast-dissolving films formulated as a novel drug delivery technology can increase the solubility and dissolution rate of poorly water-soluble drug Ezetimibe.
DEVELOPMENT OF QUANTITATIVE METHOD OF TULOBUTEROL HYDROCHLORIDE IN RAT PLASMA: VALIDATION AND APPLICATION TO PRECLINICAL PHARMACOKINETICS
Authors: NAZ AYESHA , SUBRAHMANYAM CVS , RACHAMALLA SHYAM SUNDER
Published: November 2023

Objective: A robust, simple, accurate, rapid, and selective bioanalytical high-performance liquid chromatography (HPLC) method was established and validated to determine the tulobuterol hydrochloride in rat plasma.
Methods: The protein precipitation method deproteinated analyte from rat plasma using acetone. The analysis of tulobuterol hydrochloride from rat plasma was accomplished using a mobile phase comprising of methanol: potassium dihydrogen orthophosphate buffer (0.05M; pH 4.0) in 90:10 (v/v) ratio run at 1.0 ml/min flow rate. Separation was carried on BDS hypersil C18 column (4.6 mm × 250 mm; 5 µ) at ambient temperature employing a 996 photodiode array (PDA) detector at 228 nm.
Results: The linearity model was exhibited from 100-500 ng/ml with a good correlation of 0.999. Tulobuterol hydrochloride was efficiently separated at a retention time of 7.281 min. The percent recovery rate was between 100.21-100.46 %. The accuracy, precision, robustness, and ruggedness study showed relative standard deviation (%RSD) was within 2% (acceptable limit), and that revealed the method was efficient, precise, reliable, and reproducible.
Conclusion: A simple, accurate, suitable method to quantitate tulobuterol hydrochloride in rat plasma was established using HPLC employed with a PDA detector that overcomes the increased cost for analysis. The developed method was successfully validated in rat plasma.
AN UP-TO-DATE REVIEW: MICROSPHERES AS A NEW DRUG DELIVERY SYSTEM
Authors: DESNITA RISE , NOVIANA EKA , ZAI KHADIJAH , SAIFULLAH SULAIMAN TEUKU NANDA
Published: November 2023

The application of microsphere systems in drug preparations has seen a significant increase in recent years for various purposes. Microsphere systems can be utilized in a range of drug preparations, utilizing polymer types that are appropriate for the intended release target. Microspheres offer numerous benefits and can be used in various applications, including spacer applications, medication administration, and medical diagnostics. Microspheres have minimal negative effects, a more extended therapeutic effect, require fewer doses, and provide more consistent medication absorption. Additionally, they are adaptable, offer effective encapsulation, and are cost-effective. This overview was compiled to provide an up-to-date summary of the latest developments in new drug delivery systems utilizing microsphere dosage forms. Literature from Scopus, ScienceDirect, and PubMed from 2019 to 2022 was searched to provide the latest information. The use of microsphere systems is categorized into various new drug delivery routes, including gastroretentive, colon, nasal and pulmonary, parenteral, ocular, and topical applications.
DEVELOPMENT OF ACECLOFENAC LOADED MICROSPONGE GELS: A STATISTICAL QUALITY BY DESIGN (QBD) APPROACH TOWARDS OPTIMIZATION AND EVALUATION
Authors: K. RAKHIMOL , BIJU PRAJITHA , S. M. SINDHOOR , AGGARWAL NATASHA NAVAL , V. SANDHYA , RAI DEEKSHA
Published: November 2023

Objective: The current research aims to deliver Aceclofenac in a controlled manner through a microsponges-loaded drug delivery system for the treatment of inflammation.
Methods: The formulations were prepared by the Quasi-emulsion solvent diffusion method and characterized for particle size and drug entrapment efficiency. For the optimization of the formulation through the Quality by Design (QbD) approach, Quality target product profiles (QTPP) were set up considering various key factors that affect the quality of the formulation. Further optimization of the important factors in relation to the major Critical Quality Attributes (CQAs) was conducted by applying full factorial design using the Design of Expert Software (11.0 software, Stat-Ease, Inc., USA). The optimized formulation was incorporated into the gel, and characterized for morphological analysis by Scanning Electron Microscopy (SEM), drug content, and ex-vivo permeation studies (DD solver, Version 2.0).
Results: It was found that process parameters such as drug-to-polymer ratio, the volume of the internal phase, and concentration of the emulsifier and polyvinyl alcohol (PVA), played a crucial role in improving the drug entrapment efficiency and particle size. On the other hand, stirring time did not significantly affect the particle size. Through Design of Expert (DOE) analysis, a PVA concentration of 0.641 mg/ml and an internal phase volume of 12.5 ml were identified to be the ideal concentrations to obtain the optimized microspongal gel formulation (MS4). Characterization studies were carried out on MS4, which displayed a drug encapsulation of 94%, with a Cmax of 81.62 mg/ml, and a Tmax of 12 h. Stability studies carried out as per the International Conference of Harmonization (ICH) guidelines confirmed no noticeable change in physical appearance and drug content.
Conclusion: Overall, this study focused on optimizing the formulation of microsponges for efficient dermal drug delivery, considering various critical variables and process parameters. The resulting optimized formulation demonstrated promising drug release and potential for the effective management of inflammation disorders.
BIOEQUIVALENCE OF METFORMIN AS AN ORAL ANTIDIABETIC: A SYSTEMATIC REVIEW
Authors: DARUSMAN FITRIANTI , RUSDIANA TAOFIK , SOPYAN IYAN , YULIAR NIKEN FITRIA , ARYANI RATIH
Published: November 2023

Metformin is the first line in type 2 Diabetes Mellitus (DM). Metformin is available as an innovator drug and copy drug. The high price of innovator drugs makes it difficult for patients to obtain the required drugs. Therefore, many pharmaceutical industries have developed a copy of the innovator drug. To obtain .a distribution license, the pharmaceutical industry must conduct a bioequivalence test on metformin copy tablets to ensure that the copy drug has the same efficacy, safety, and quality as the innovator drug. However, several surveys show that most patients believe that the effectiveness of copy drugs is not equivalent to the innovator drug. This study aims to determine the bioavailability profile and bioequivalence profile of Metformin copy tablets to Glucophage® (Merck) innovator tablets so that it can provide an overview of the effectiveness of copy drugs with innovator drugs and the public no longer hesitate to use copy drugs. Metformin copy tablets are declared bioequivalent to the innovator drug if they provide a Confidence Interval (CI) value of 90% in the 80-125% range. All 500 mg, 850 mg, and 1000 mg doses of metformin copy tablets, both fasting and eating conditions, gave bioequivalent results to the innovator Glucophage® based on 90% CI.
FELODIPINE-REVIEW OF ANALYTICAL METHODS DEVELOPED FOR PHARMACEUTICAL DOSAGE FORMS AND BIOLOGICAL FLUIDS
Authors: MALLI KIRAN , KUMAR LALIT , VERMA RUCHI
Published: November 2023

Felodipine (FDP) is a vascular selective L-type calcium channel blocker, in hypertension patients FDP significantly lowers systolic and diastolic blood pressure (BP). It is a lipophilic drug molecule that contains a dihydropyridine ring responsible to show pharmacological activity, it is mainly used to control and prevent essential hypertension. This review article provides a summary of various analytical techniques for determining felodipine in pure form, pharmaceutical formulations, and biological fluids. Various analytical techniques are developed and validated, such as ultraviolet/visible spectrophotometry, high-performance liquid chromatography (HPLC), high-performance thin layer chromatography (HPTLC), and bioanalytical techniques. Estimated validation parameters such as linearity, LOD (Limit of Detection), and LOQ (Limit of Quantification) are discussed for each method. The wavelength of detection (λmax), mobile phase, columns, flow rate, retention time (Rt) and sample preparation techniques are all important quality elements for calculating Felodipine via analytical procedures.
AN ELECTROMETRIC METHOD FOR THE DETERMINATION OF IMPACT OF DMSO-WATER MIXTURES ON pKa VALUES OF SALICYLIC ACID DERIVATIVES
Authors: BALAKRISHNA M. , NEERAJA R. , KUMAR J. SURESH , RAMANAIAH M.
Published: November 2023

Objective: The main objective of this present study is to conduct an experiment to analyze the variation of protonation-deprotonation equilibria with regards to the dielectric constants of an organic medium, influence of errors on protonation constants and effect of pH on the percentage of species.
Methods: The present investigation was carried out by using pH meter at a temperature of 303 K and ionic strength of 0.16 mol dm-3 in Dimethyl sulfoxide (DMSO)-water mixtures. The processing of data was done by using Gran plot titration. The advanced principles of mathematics and fuzzy logic have been employed to correlate chemical problems, known as chemometrics. To obtain best-fit chemical models, a modelling strategy such as SCPHD is used and a computer program MINIQUAD 75 is also employed for the refinement of results.
Results: In the present study, we found the influence of dielectric constants of a medium Dimethyl sulfoxide (DMSO)-water on protonation constants of 5-Sulfosalicylic acid and 5-Hydroxysalicylic acid has been studied. The species distribution diagrams were presented and understood the effect of pH on the percentage of species. The obtained skewness values are ranging from 0.11-0.36 and–0.56-0.38, for 5-Sulfosalicylic acid (5-SSA) and 5-Hydroxysalicylic acid (5-HSA), respectively, which describes the distribution curves are right skewed and left skewed. The kurtosis values are ranging from 2.12-3.56, which indicates the peak of the distribution curve exhibits both platykurtic and leptokurtic pattern. The changes in the concentrations of some influential parameters such as log F, acid, alkali, volume of titrands, ligand causes variation of stability constants and the order of the effect of influential parameters on stability constants are as alkali>acid>ligand>volume of titrand>log F.
Conclusion: It is observed that the significant influence of co-solvent Dimethyl sulfoxide (DMSO)-Water mixtures on the protonation constants of ligands also studied how some factors such as changes in concentrations of ligand, acid, base log F and volume of the solution have influence on the protonation constants.
UPLC-HR-ESI-MS ANALYSIS AND ANTIPROLIFERATIVE AND ANTI-DIABESITY SCREENING OF FLOWERS, ROOTS, AND AERIAL PARTS OF SOLANUM ELAEAGNIFOLIUM CAV.
Authors: AL-HAMAIDEH KHAWLA DHAMEN
Published: November 2023

Objective: Solanum elaeagnifolium Cav. is an invasive summer-growing wild perennial herb but is traditionally used to treat some health conditions, including toothache and constipation. This study aimed to identify the chemical composition of various parts of this herb (flowers, roots, and aerial parts) and explore its biological properties.
Methods: Ultra-Performance Liquid Chromatography-Mass Spectrometry (UPLC-MS) was used for the first time for the root to analyze the hydro-alcoholic extract besides flowers and aerial parts of S. elaeagnifolium. Sulforhodamine B (SRB) assay was used to assess the antiproliferative effects of the same extracts on the colorectal cancer cell lines (CACO2, SW620, HT29, and HCT116). The aqueous extracts of the plant’s three parts were evaluated in vitro for their anti-diabesity properties.
Results: For the first time, other compounds in three plant parts were identified using UPLC-MS: hyperoside and apigenin (flavonoids), in flowers and roots, naringin (flavonoid) in the roots, and apigenin (flavonoid) in aerial parts, diosgenin (steroids sapogenin) solamargine, and solasodine (alkaloids) in the three parts. In addition to the previously identified compounds; chlorogenic acid and kaempferol were in the aerial part, and flowers; and luteolin (flavonoids) were in the aerial parts. Pharmacologically, the aqueous extracts of flowers and roots proved anti-diabesity activity, and no anti-proliferative effect was detected for their hydro-alcoholic extracts. Neither anti-obesity nor anti-proliferative activities were detected in the aerial part extracts. 
Conclusion: Further in vivo and in vitro investigations are required for the different parts of S. elaeagnifolium to explore more biological activities and evaluate the plant’s toxicity.
A ATUAÇÃO DA REDE ESTADUAL DE EDUCAÇÃO DE ALAGOAS NA CULTURA DE AVALIAÇÃO
Authors: Karina Souto Maior de Melo Fernanda , Da Silva Givanildo
Published: November 2023

Este trabalho tem como objetivo dialogar a respeito da atuação da rede estadual de educação do estado de Alagoas a partir do discurso sobre a cultura de avaliação, em que as escolas devem seguir os preceitos neoliberais, os princípios e as estratégias gerenciais para alcançar um serviço eficiente, eficaz e de qualidade. Nesse contexto, a educação pública sofreu reformas no intuito de se ajustar aos ditames mercadológicos e da qualidade educacional aferida, unicamente, pelo viés quantitativo, por meio das avaliações externas introduzidas na educação básica na década de 1990. A metodologia do trabalho esteve pautada na abordagem qualitativa de caráter exploratório, utilizando-se do estudo de caso, como técnica de pesquisa, com o objetivo de apresentar a perspectiva da 2ª Gerência Regional de Educação a respeito da temática. Os principais resultados apontaram que o modelo gerencial está enraizado na rede estadual e que os princípios da eficiência, da eficácia e da produtividade vêm sendo vivenciados com engajamento pelos líderes educacionais, em detrimento do atendimento da função social da escola que valorize a emancipação humana. Sendo assim, atribui- se à cultura da avaliação como impulsionadora da qualidade educacional dos tempos atuais.
Problematika Sistem Presidential Threshold dalam Pemilihan Presiden dan Wakil Presiden dalam Perspektif Sistem Presidensial di Indonesia
Authors: Rasfanjani Fawzi Ali Akbar , Jumadi  , Arbani Tri Suhendra
Published: November 2023

Ketentuan ambang batas pencalonan Presiden atau presedential threshold yang masih diterapkan dalam pemilihan umum Presiden terutama dalam kaitannya dengan akan diberlakukannya pemilihan umum serentak tahun 2019 memang masih menjadi perdebatan. Berdasarkan hal itu ;Apakah Dampak Hukum Presidential Threshold dalam Sistem Pemilihan Presiden dan Wakil Presiden di Indonesia?Bagaimana Korelasi Sistem Presidential Treshold Terhadap Pemilu Serentak Tahun 2019 Perspektif Sistem Presidensil di Indonesia Hasil penelitian ini menunjukkan bahwa dampak hukum yang paling dirasakan adanya aturan Presidential Threshold adalah orang yang berkepentingan pada pemilu serentak tahun 2019. Hak partai politik menjadi terciderai karena aturan tersebut. Meskipun Mahkamah Konstitusi menyatakan bahwa aturan Presidential Threshold yang terdapat didalam UU No. 7 tahun 2107 tidak bertentangan dengan UUD 1945 dan dinyatakan sah, namun sebenarnya aturan tersebut masih cacat konsep dan tidak ada acuan yang jelas sebagai ambang batas karena menggunakan hasil pileg sebelumnya. Korelasi antara Presidential Threshold dengan pemilu serentak adalah dimaksudkan untuk menguatkan sistem presidensiil yang dianut oleh bangsa Indonesia
Eksaminasi Penanganan Tindak Pidana Korupsi Dana Desa
Authors: Amin Muh Nurisrahmat , Jayadi Ahkam , Sinilele Ashar
Published: November 2023

Meningkatnya kasus korupsi yang terjadi di Indonesia menunjukkan keprihatinan bangsa ini. Sebab pelaku tindak pidana korupsi di Indonesia sebagian besar dilakukan oleh orang-orang yang memiliki kewenangan dalam jabatannya. Hal ini juga terlihat dari kasus dalam Putusan Nomor 76 /Pid.Sus-TPK / 2019 / PN.MK, dimana tergugat adalah PNS (PNS) yang diputuskan oleh hakim Pengadilan Negeri Makassar, bahwa mereka terbukti secara sah dan meyakinkan mereka untuk melakukan tindak pidana korupsi sehingga dinyatakan bersalah Terdakwa ini terkena kasus korupsi terkait Dana Desa di Bategulung pada masa jabatannya. Hakim menyatakan bahwa unsur-unsur dakwaan penyalahgunaan dana desa merupakan bagian dari tindak pidana korupsi, yang sesuai dengan Undang-Undang Nomor 31 tahun 1999 tentang Pemberantasan Tindak Pidana Korupsi bersambung dengan Pasal 64 Ayat (1) KUHP.  Berdasarkan fakta di persidangan, jaksa penuntut umum telah memberikan bukti dan para saksi, bahkan para pengkhotbah, mengakui kesalahannya sehingga hakim memutuskan untuk dipenjara selama 1 (satu) tahun dan denda sebesar Rp. Rp.55.404.454, - sesuai dengan batas minimum yang ditetapkan dalam Pasal 2 Ayat (1) Undang-Undang Nomor 20 tahun 2001 tentang Perubahan atas Undang-Undang Nomor 31 tahun 1999 tentang Pemberantasan Tindak Pidana Korupsi bersambung dengan Pasal 64 Ayat (1) KUHP
Analisis Concursus Tindak Pidana Pembunuhan dan Penganiayaan Berat (Suatu Tinjauan Kriminologi)
Authors: Amalia Maisarah , Kahfi Ashabul , Sastrawati Nila
Published: November 2023

Tindak pidana concursus pembunuhan disertai penganiayaan berat yang dilakukan seseorang sangatlah meresahkan masyarakat, dalam kasus ini membuktikan bahwa tidak selamanya faktor utama penyebab kejahatan terjadi dipengaruhi dari faktor keluarga, rendahnya pendidikan bahkan lingkungan masyarakat sekitar. Tetapi yang menjadi faktor utama dalam kasus ini adalah faktor kejiwaan dan sakit hati yang menimbulkan rasa dendam. Permasalahan yang dibahas dalam penelitian ini adalah penyebab terjadinya tindak pidana concursus pembunuhan disertai penganiayaan berat dan upaya penanggulangannya. Penelitian ini merupakan penelitian lapangan dengan menggunakan metode kualitatif yang disajikan dalam bentuk yuridis empiris. Hasil penelitian ini menunjukkan bahwa penyebab terjadinya tindak pidana concursus pembunuhan disertai penganiayaan berat ini meliputi faktor yang berpengaruh secara langsung yaitu faktor sakit hati dan kejiwaan, serta faktor yang berpengaruh secara tidak langsung yaitu faktor lingkungan masyarakat sekitar, rendahnya pendidikan, serta faktor keluarga. Dan upaya yang dilakukan oleh kepolisian yaitu, upaya pre-emtive, upaya preventif, serta upaya represi.
Efektivitas Peraturan Daerah tentang Lembaga Adat Daerah: Studi Kabupaten Gowa
Authors: Amin Imran Rosyadi , Marilang  , Asmar Abd. Rais
Published: November 2023

Pokok masalah dalam penelitian ini menyoal tentang efektivitas PERDA No.5 Tahun 2016 Tentang Lembaga Adat Daerah di Kabupaten Gowa Serta Faktor-Faktor yang menjadi Pendukung dan Penghambat dalam Proses Implementasi Perda LAD ini. Dalam penelitian ini menggunakan jenis penelitian yang bersifat deskriptif. dimana dalam hal ini peneliti berfokus pada kondisi dan situasi masyarakat yang ada khususnya di Kabupaten Gowa. Proses perancangan, pembahasan, dan penetapan dalam pembuatan Perda LAD di Kabupaten Gowa telah mengikuti prosedur penyusunan Pembuatan Perda. Namun melalui proses panjang sebelum perda ini di sah kan, ada beberapa pasal yang di ubah termasuk dari judul perda ini sendiri setelah diadakan evalusi oleh beberapa pihak diantaranya adalah mengenai angka 3 Bupati adalah Bupati Gowa sebagai ketua lembaga adat daerah yang menjalankan fungsi dan peran sombayya selanjutnya, dalam proses perjalanannya Perda LAD ini menimbulkan konflik antar pemerintah daerah Dalam proses perancangan, pembahasan dan penetapan Perda LAD di Kabupaten Gowa mengalami dinamika.
Penerapan Regulasi tentang Pekerja Sosial terhadap Lembaga Pekerja Sosial di Kota Makassar
Authors: Alfian Muh. , Syamsuddin Rahman , Fuady Muhammad Ikram Nur
Published: November 2023

Tujuan penelitian ini adalah menganalisis rencana kerja Kementerian Sosial dalam melaksanakan perlindungan dan pembinaan anak jalanan di Kota Makassar, dan menganalisis faktor penghambat rencana kerja Kementerian Sosial. Pertanyaan penelitian ini adalah apakah implementasi rencana pembinaan dan perlindungan anak jalanan yang dilaksanakan oleh Kementerian Sosial telah memenuhi harapan/hasil, dan faktor-faktor yang menghambat Kementerian Sosial dalam melindungi dan membesarkan anak jalanan di Makassar. Berdasarkan hasil penelitian ini dapat disimpulkan bahwa sistem perlindungan dan pengasuhan bagi anak jalanan dilaksanakan sesuai dengan tugas dan fungsinya. Kalaupun sudah diterapkan, masih ada anak jalanan yang turun ke jalan lagi. Oleh karena itu, perlu diupayakan kerjasama pemerintah, dari satu pemerintah ke pemerintah lain, dan bekerja sama dengan masyarakat, lembaga swadaya masyarakat dan instansi terkait lainnya dalam perlindungan dan pengembangan anak jalanan.
Tinjauan Hukum Positif dan Hukum Islam Meminjam Barang pada Wilayah Publik Tanpa Akad Sharih
Authors: Handoko Riki , Tanjung Dhiauddin
Published: November 2023

Islam mengatur tentang tatacara ber-mu’amalah sebagai sarana hablun minnan nas dengan menerapkan akad yang sesuai dalam setiap kegiatan yang dilakukan. Pinjam-meminjam barang adalah hal yang umum dalam ber-mu’amalah, namun dalam hal pinjam-meminjam pada area publik tidak jelas apa akad yang digunakan sehingga tidak diketahui batasan-batasan tentang pinjam meminjam di area publik. Sehingga tujuan penulisan ini untuk mengetahui kedudukan hukum fiqh terhadap meminjam barang pada wilayah publik tanda akad sharih. Penelitian ini menggunakan metode penelitian kualitatif dengan analisis deskriptif berdasarkan kajian Pustaka secara umum. Dari hasil penelitian ditemukan meminjam barang tanpa akad sharih pada wilayah publik secara umum dapat dikatagorikan sebagai ariyah, dimana merupakan pinjam meminjam dengan tujuan tolong menolong, dimana musta’ir meminjam barang kepada mu’ir untuk diambil mamfaatnya, dan setelah selesai barang yang dipinjam haruslah dikembalikan, dimana akad dapat dilihat dari niat peminjam sebagai mu’ir kepada yang meminjam sebagai musta’ir.
Analisis Hukum Pelaksanaan Diskresi Kepolisian dalam Tindak Pidana Narkotika
Authors: Datu Nur Fathahita  , Asis Abd. , Basri Muhammad
Published: November 2023

Penelitian ini bertujuan untuk mengetahui pelaksanaan diskresi terhadap tindak pidana narkotika di Kepolisian Resor Bulukumba dan untuk menganalisis pelaksanaan diskresi terhadap tindak pidana narkotika oleh Kepolisian Resor Bulukumba sesuai dengan prinsip-prinsip diskresi kepolisian. Penelitian ini menggunakan metode penelitian hukum normatif-empiris dilakukan dengan pendekatan kasus, perundang-undangan, dan studi kepustakaan yang berkaitan dengan permasalahan yang diteliti. Adapun hasil penelitian ini, yaitu 1. Diskresi kepolisian yang diterapkan yakni penangkapan yang dilakukan pihak kepolisian terhadap pelaku tindak pidana narkotika tanpa adanya surat perintah penangkapan sebelumnya dengan dasar keyakinan dan pertimbangan pihak kepolisian bahwasanya segera mengambil tindakan untuk menangkap pelaku tindak pidana narkotika, karena apabila tidak dilakukan penangkapan pada saat itu juga dikhawatirkan pelaku akan melarikan diri, merusak dan atau menghilangkan barang bukti tindak pidana narkotika tersebut. 2. Diskresi yang dilakukan oleh anggota kepolisian berdasarkan kedua kasus tersebut sesuai dengan asas keperluan, asas kepentingan, asas tujuan, dan asas keseimbangan.
Hukum Islam dalam Konstitusi Negara Indonesia
Authors: Nasim Abu Sahman , Misbahuddin  , Bakence Lutfi , Basirun Adam , Hisbullah
Published: November 2023

Penelitian ini mengkaji tentang konstitusi hukum Islam sebelum kemerdekaan dan sesudah kemerdekaan sejak kemerdekaan 1945 sampai sekarang. Penelitian ini menggunakan deskriptif kualitatif. Hasil penelitian ini menunjukkan bahwa konstitusi hukum Islam dalam negara Indonesia telah mengalami perubahan dan perkembangan yang sangat signifikan, walaupun pada masa pertengahan kemerdekaan perkembangan konstitusi hukum Islam telah menerobos serta mempengaruhi untuk masuk kedalam konstitusi-konstitusi negara Indonesia secara berkala dan berkelanjutan, namun setelah pertengahan kemerdekaan, terjadi perubahan 4 kali amandeme UUD 1945, hal ini yang membuka ruang perkembangan hukum Islam dalam konstitusi-konstitusi negara Indonesia mengalami kemajuan yang signifikan sehingga beberapa produk undang-undang dapat menjadi pertimbangan untuk masuk dalam materi perundang-undangan yang dapat pula berpengaruh sistem hukum ketatanegaraan di Indonesia.
Analisis Hukum Terhadap Perjanjian Hutang Piutang dengan Jasa Kalampa Piti di Kota/Kabupaten Bima
Authors: Wirawan A. Rachmat , Komuna Avelyn Pingkan , Robiansyah Anton
Published: November 2023

Praktek utang piutang dijadikan sebagai sarana untuk mendapatkan penghasilan dari pemberian utang dengan kelebihan dari saat pengembalian yang kemudian dikenal dengan rentenir. Di Kota Bima praktik rentenir kemudian dikenal dengan sistem “kalampa piti” atau membungakan uang dari pinjaman. Hukum di Indonesia sendiri tidak melarang adanya bunga dalam setiap transaksi pinjam meminjam. Hal ini bisa dilihat pada pasal 1754 BW yang juga diperkuat dalam pasal 1765 BW yang memperbolehkan adanya bunga dalam setiap transaksi peminjaman. Namun yang menjadi permasalahan adalah proses kesepakatan perjanjian hutang piutang yang didasari pernyataan secara lisan tanpa adanya kesepakatan tertulis yang menyebabkan konflik antara pihak kalampa piti dengan nasabah berupa kekerasan fisik, psikis hingga perampasan barang berharga. Untuk itu perlu adanya prosedur konkrit untuk menjamin kepastian dan perlidungan hukum terhadap para pihak.
Kedudukan Mahar dalam Sistem Perkawinan Adat Mandar
Authors: Andi Dewi Pratiwi
Published: November 2023

Penelitian ini bertujuan untuk menganalisis kedudukan hukum uang belanja dan kelengkapan uang belanja dalam sistem adat Perkawinan Mandar. Pengaturan mengenai keberadaan dan hak-hak masyarakat hukum adat di Indonesia terdapat di dalam UUD 1945. Dapat dilihat pada Pasal 18B ayat (2), Pasal 281 ayat (3). Sehingga kesepakatan passorong maupun kesepakatan uang belanja serta kelangkapan uang belanja merupakan bagian dari hak-hak tradisional hukum adat yang diakui keberadaannya. Kesepakatan uang belanja merupakan salah satu prasyarat dari suatu perkawinan dalam Suku Mandar yang merupakan suatu prestise yang dituangkan dala bentuk komitmen atau perjanjian antara dua belah pihak yaitu keluarga calon mempelai pria dan calon mempelai wanita. Melihat unsur kesepakatan uang belanja serta kelengkapan uang belanja ini yang dimana melalui suatu pertemuan untuk melakukan kesepakatan bersama dengan melakukan perikatan antara dua belah pihak maka kesepakatan ini melahirkan suatu perjanjian yang berarti terpenuhinya isi Pasal 1320 KUHPerdata tentang syarat sah suatu perjanjian.
Tinjauan Yuridis Sosiologis Terhadap Tindak Pidana Perjudian di Kabupaten Bulukumba
Authors: Sari Eka Anugra , Hamsir
Published: November 2023

This research analyzes the application of criminal law to gambling offenses and the efforts of law enforcement in combating gambling in Bulukumba. Using normative and empirical juridical approaches, the study finds that environmental factors, hobbies, unemployment, and the desire for quick financial gain contribute to the prevalence of gambling. Article 303 of the Criminal Code threatens imprisonment of up to 10 years or a fine of 25 million Indonesian Rupiah for those who facilitate gambling, and imprisonment of up to 4 years and a fine of 10 million Indonesian Rupiah for gambling participants. The Law No. 7 of 1974 also declares gambling as a criminal offense. This research highlights the importance of law enforcement efforts in preventing and prosecuting gambling offenses.
Pelaksanaan Pengawasan Makanan yang Beredar pada Konsumen oleh BBPOM di Makassar (Studi Pelaksanaan UU No. 8 Tahun 1999 tentang Perlindungan Konsumen)
Authors: Amrizal  , Istiqamah
Published: November 2023

This research discusses the "Implementation of Food Supervision on Consumer by BBPOM in Makassar". The purpose of this study is to understand the implementation of BBPOM supervision in Makassar regarding the circulation of expired food and the factors that hinder BBPOM in conducting supervision. This research uses a qualitative approach with field research methods and data collection through interviews. The results show that the supervision carried out by BBPOM in Makassar on food that does not meet quality standards, especially expired food, has been performed well, as evidenced by the cases discovered by BBPOM. The factors influencing BBPOM's performance in supervision are not yet optimal due to internal and external factors. The implication of this research is that the government should consider increasing the number of staff at the POM Office, with a proposal from BPOM to the government. Increasing staff numbers will have a positive impact on enhancing BPOM's performance in supervision, especially in a large working area.
Perlindungan Hukum Terhadap Anak yang Diterlantarkan
Authors: Utami Rifka Aulia , Jumadi
Published: November 2023

Children are a mandate and a gift from Almighty God, which is inherent in their dignity and their dignity as a whole human being. Children need special handling, but not all parents who sincerely accept children and give love. Parents sometimes don't care about parents' lack of care and affection for their children. Few parents accept disabled children with a sincere heart. This has caused many cases of parents who have abandoned their children. The method of this research is a normative legal research aiming to find and formulate legal arguments, through the analysis of the main problem. The technique of collecting legal documents is done by studying literature. The approach used in this study is the statutory approach, in particular by examining the legal rules applicable with regard to the legal protection of children abandoned by their parents. Interviews were conducted at the Integrated Service Center for the Empowerment of Women and Children (P2TP2A) in the city of Makassar, as support and to refine the normative analysis.
Pelaksanaan Pelayanan Publik di Bidang Pendidikan sebagai Implementasi Kebijakan Otonomi Daerah di Kabupaten Gowa
Authors: Sukma Nur Ichsan , Jayadi Ahkam
Published: November 2023

The main problem of this research is how public services in the field of education in Gowa Regency. The subject matter is then included in several subproblems or research questions, namely: 1) how is the implementation of the public in the field of education as the implementation of regional autonomy policies in Gowa Regency?, 2) What are the factors that affect the performance of the Education Office in implementing public services as the implementation of regional autonomy policies in Gowa Regency?. The results of this study indicate that: 1) Public implementation in the field of Education as the implementation of regional autonomy policies in Gowa Regency is good because the government first designs all programs that will be carried out later. 2) The factors that influence the performance of the Gowa Regency Education Office in carrying out the implementation of regional autonomy are due to several factors including the organizational structure factor and the public service apparatus.
Implementasi Peraturan Daerah tentang Bangunan Gedung dan Surat Keputusan Bersama 2 Menteri terhadap Pembangunan Rumah Ibadah Non-Muslim di Kabupaten Jeneponto
Authors: Rifat Andi Muh. Iqrah , Marilang
Published: November 2023

Implementation of Regional Regulation No. 3 of 2014 concerning Buildings and the Joint Decree (SKB) of 2 Ministers on the Construction of Non-Muslim Houses of Worship by describing some of the results of the research while on site. This research in Kec. Binamu Kab. Jeneponto, field research with an empirical approach which is one of the research methods that uses descriptive data in the form of words from related parties which is then supported by various literary sources from books, journals, articles, theses and other written works. The results obtained by the author in this study Implementation of Ministerial Decree No. 2, 8 and 9 of 2006 and Regional Regulation No. 3 of 2014 Regarding Buildings, everything has been clearly regulated and has been running properly. Without exception the construction of houses of worship which often triggers conflicts to this day. Even though it is clear that the provisions in the above rules do not distinguish between the construction of Muslim and non-Muslim houses of worship. Because the administrative requirements are the same.
Tinjauan Yuridis tentang Pengembalian Mahar Akibat Perceraian
Authors: Adiliah Nur , Erlina  , Nurjannah St.
Published: November 2023

This study aims to analyze the basic legal considerations of judges in judging the case of the return of dowry entirely due to divorce, as well as factors that cause the return of dowry. This study uses the method of library research by collecting data through quoting, adapting, and analyzing the contents of the literature relevant to the problems discussed. The results showed that in the decisions that were used as Case Studies, no judge decided to return the entire dowry given to the husband. This is in accordance with the provisions of Article 35 paragraph (1) KHI which requires the husband to pay half the dowry when mentalaq qabla al-dukhul. The factors that led to the return of the dowry are, among others, arranged marriages by families and disagreements. This research is broadly in accordance with the legislation in force in the religious courts.
Analisis Perlindungan Hukum Terhadap Konsumen yang Dirugikan dalam Transaksi Jual Beli pada Situs Belanja Daring
Authors: Ela  , Solaiman Eman
Published: November 2023

This study analyzes the legal protection of consumers who are at a loss in buying and selling transactions on online shopping sites. This research is expected to provide benefits both scientifically in the study of legal science, as well as practically and academically, which can be used as input for writers for those who have a desire to analyze the process of buying and selling online and the responsibility of business actors to consumers. who are disadvantaged in buying and selling transactions on online shopping sites. The research method used in this study is a normative juridical research method, namely research refers to legal norms that exist in legislation, literature, opinions experts, papers. The author analyzes how the responsibility of business actors to consumers who are at a loss in buying and selling transactions on online shopping sites. The law used in this research is Article 7 letter g of the Consumer Protection Act, so business actors are obliged to provide compensation, compensation and/or replacement if the goods and/or services received or used are not in accordance with the agreement.
Efektivitas Hukum Pemenuhan Hak Restitusi Terhadap Tindak Pidana Perdagangan Orang di Kota Makassar
Authors: Saodana Shafira , Muchtar Syamsuddin , Azisa Nur
Published: November 2023

This study aims to analyze the effectiveness of the law on the fulfillment of the right of restitution Against Trafficking in Persons in Makassar. This study uses empirical legal methods, using a qualitative approach. The results of this study are (1) the fulfillment of the right of restitution to victims of trafficking in Persons is regulated in Law Number 21 of 2007 concerning the eradication of trafficking in Persons. The public prosecutor informs the victim of the right to request restitution which then the public prosecutor informs the amount of losses suffered by the victim due to the crime of trafficking in persons.  (2) the effectiveness of the fulfillment of the right to restitution of victims of trafficking in Persons has not been effective because the law enforcement officers, especially investigators and prosecutors lack understanding related to restitution submission
Analisis Kewenangan Lembaga Penjamin Simpanan (LPS) dalam Upaya Penjaminan Dana Nasabah
Authors: Al-Amanah Tuhfatul Abrar , Sumardi Juajir , Famauri Andi Tenri
Published: November 2023

This study aims to implement the Authority and Role of the IDIC in Efforts to Guarantee Customer Funds to provide a sense of security for public savings funds in banks. The method of research is qualitative, using interviews and documentation as data collection methods. The results of this study indicate that (1) The authority and role of LPS in guaranteeing public savings in the banking world is to provide a sense of security for customer deposit funds; (2) the occurrence of cases of bank failures, break-ins, and slips of funds that occurred in the banking world. This is a form of violation that is detrimental to the customer, and LPS, in accordance with the applicable laws and regulations, has the authority to guarantee customer deposits at the bank.
Problematika Rangkap Jabatan ASN, TNI, dan Polri Menjadi Komisaris di Badan Usaha Milik Negara
Authors: Wahyudi Ahmad , Safriani Andi , Nurjannah St.
Published: November 2023

Permasalahan terkait rangkap jabatan bukanlah hal baru dan menjadi masalah karena melanggar peraturan perundang-undangan, terutama UU ASN, UU TNI, dan UU Polri. Oleh karena itu, terkait dengan kasus tersebut, penelitian ini dilakukan untuk meninjau pertimbangan diangkatnya ASN, TNI, dan Polri sebagai komisaris di BUMN dan meninjau akibat hukum yang timbul dari diangkatnya ASN, TNI, dan Polri menjadi komisaris di BUMN. Penelitian ini bersifat hukum normatif (library research) dengan menggunakan pendekatan perundang-undangan (statute approach) dan disajikan dalam bentuk analisis deskriptif. Hasil penelitian menunjukkan bahwa pertimbangan diangkatnya ASN, TNI, dan Polri sebagai komisaris di BUMN didasarkan pada tidak adanya aturan yang secara eksplisit melarang, sehingga dianggap dapat menjadi penyeimbang bagi BUMN. Namun, akibat hukum dari diangkatnya ASN, TNI, dan Polri sebagai Komisaris di BUMN, sesuai dengan peraturan yang dilanggar, mengharuskan pihak terkait untuk diberhentikan atau mengundurkan diri dari jabatannya.
Efektifitas Penjatuhan Sanksi oleh Majelis Kode Etik ASN Terhadap Pelanggaran Kode Etik ASN di Kota Makassar (Studi Kasus 2014-2015)
Authors: Agus Sahran M. , Jayadi Ahkam
Published: November 2023

Hukum adminstrasi negara merupakan suatu perangkat aturan yang memungkinkan admnistrasi negara melakukan fungsinya,yang juga sebagai pelindung warga negara terhadap tindak perbuatan admnistrasi negara dan sebagai pelindung admnistrasi negara itu sendiri. Sebagai contoh banyaknya kasus pelanggaran kode etik ASN dikota Makassar tahun 2014-2015. Hasil informasi yang didapatkan yaitu pelaksanaan penjatuhan sanksi di Pemerintah kota Makassar belum sepenuhnya mengikuti ketentuan Peraturan Pemerintah Nomor 53 tahun 2010. Adapun faktor penghambat pelaksanaan penjatuhan sanksi di Pemerintah Kota Makassar yaitu Disebabkan karena adanya pembiaran yang dilakukan oleh atasan, Kurangnya kesadaran Pegawai Negeri Sipil dalam melakukan kewajibannya dan berkomitmen untuk tidak melakukan pelanggaran disiplin, dan situasi politik, sering menjadi penghambat dalam penjatuhan sanksi di Pemerintah Kota Makassar. Dalam penelitian ini penulis, penulis ingin mengetahui apa yang menjadi faktor ASN melakukan pelanggaran kode etik dan penyebab terhambat jatuhnya sanksi terhadap ASN yang melanggar,dengan menggunakan metode Yuridis Empiris dan berlokasi di Badan Kepegawaian dan Sumber Daya Manusia Daerah kota Makassar.
Analisis Tingkat Kejahatan di Kota Makassar Akibat Pandemi Covid-19
Authors: Ramadhani Andi Muhammad Aidul Syah , Amiruddin Muh. , Solaiman Eman
Published: November 2023

Penelitian ini bertujuan mengetahui jumlah peningkatan kejahatan akibat pandemi covid-19 dan untuk lebih mengetahui pengaruh terjadinya kejahatan di Kota Makassar selama pandemi covid 19. Penelitian yang digunakan dalam penulisan skripsi ini yaitu penelitian empiris. Dalam artian melakukan telaah pada aturan-aturan yang ada (normatif) baik berupa peraturan-peraturan pemerintah, literatur, dan penelitian terdahulu. Sehingga melalui penelitian normatif, peneliti dapat melihat hukum secara vertikal dan juga apakah hukum mampu menjadi penengah untuk permasalahan- permasalahan yang terjadi. Jumlah peningkatan kejahatan sebab pandemi covid-19 di kota Makassar khususnya di wilayah Polrestabes Kota Makassar, meningkat 34%. Hasil tersebut didasarkan pada data yang penulis dapatkan melalui Polrestabes Kota Makassar dan wawancara langsung dengan bapak Ipda Roni Parsaulian Gultom sebagai Kasubnit Unit 1 Satuan Reserse Krimanal Polrestabes Kota Makassar dengan melakukan upaya pencegahan seperti upaya pre-entif, prefentif dan represif.
Perlindungan Hukum Bagi Pegawai Non Aparatur Sipil Negara dalam Sistem Jaminan Sosial Ketenagakerjaan Di Kota Makassar
Authors: Mardika Daniel , Bachri Syamsul , Syawiah A.
Published: November 2023

Pokok masalah penelitian ini ialah Bagaimana “Perlindungan Hukum Bagi Pegawai Non Aparatur Sipil Negara Dalam Sistem Jaminan Sosial Ketenagakerjaan Di Kota Makassar” pokok masalah tersebut kemudian dibagi menjadi submasalah atau pertanyaan peneliti yaitu: Bagaimana pelaksanaan pengaturan perlindungan jaminan sosial ketenagakerjaan di BPJS Ketenagakerjaan Kota Makassar?, Bagaimana tanggung jawab Pemerintah Kota Makassar terhadap perlindungan JKM dan JKK pegawai Non ASN dalam jaminan sosial di BPJS ketenagakerjaan ?. Jenis penelitian yang digunakan dalam penelitian ini adalah penelitian empiris. Metode penelitian hukum empiris ialah suatu metode penelitian hukum yang berfungsi untuk dapat melihat hukum dalam artian nyata serta meneliti bagaimana bekerjanya hukum di lingkungan masyarakat. Penelitian empiris ini memerlukan konsistensi untuk tetap mengacu dan merujuk pada metode yang digunakan dalam kajian ilmu sosial, seperti pengujian hipotesis, analisis deskriptif, penggunaan silogisme yang bersifat induksi, dan penentuan populasi dan sampel, agar tidak terjadi kekeliruan, ketidaklogisan, dan kesalahan dalam sebuah penelitian.
Implikasi Hak Ijbar Wali terhada Implikasi Hak Ijbar Terhadap Perceraian di Kota Makassar
Authors: Marzuki Fathurrahman , Hamid M. Arfin , Ratnawati
Published: November 2023

Perkawinan ialah ikatan lahir batin antara seorang pria dan wanita dengan tujuan membentuk keluarga (rumah tangga) yang bahagia dan kekal berdasarkan Ketuhanan Yang Maha Esa. Perkawinan merupakan sunnah Rasul yang dianjurkan untuk dilaksanakan ummatnya yang apabila dilaksanakan maka mendapatkan ganjaran pahala dari Allah SWT dan tentu juga kelak mendapatkan Syafaat Rasulullah dihari kelak. Namun, dalam pelaksanaannya perkawinan harus dengan dasar niat baik untuk menggapai Ridho Allah Swt dan harus memenuhi ketentuan syariat Islam dan peraturan hukum yang berlaku di indonesia. Sebagai perbuatan yang tidak hanya mengikatkan lahiriyah mempelai saja, perkawinan juga mengikatkan batin para mempelai. Dan untuk mengikatkan lahiriyah dan batiniyah dari para mempelai, hal paling penting untuk menjadi perhatian bahwa perkawinan ini harus lahir dari kemauan dan kesadaran para pihak sehingga tidak adanya paksaan dari pihak manapun tidak terkecuali wali atau ketidaksetujuan di dalamnya. Namun dalam prakteknya, ditemukan perkawinan yang dikarenakan paksaan/hak ijbar seorang wali yang berujung pada perceraian.