bluuebunny/crossref_metadata_2025 huggingface dataset:
Tumor Lysis Syndrome
Authors: Durfee Elizabeth Mary
Published: June 2022

Background

Tumor lysis syndrome is a life-threatening oncologic emergency in adult and pediatric patients with hematologic cancer. It occurs most often in malignancies with rapid cell turnover and large tumor burden, but its incidence has risen in solid tumors. The subsequent release of tumor cell contents into the bloodstream results in dangerous electrolyte and metabolic disturbances.

Objective

To provide acute and critical care nurses with a comprehensive review targeted to critical care nursing practice. Recognition of hallmark signs and symptoms will improve early detection and intervention.

Methods

A literature review was performed using the following keywords: tumor lysis syndrome, diagnosis, nursing, early detection, and early diagnosis in PubMed and tumor lysis syndrome, diagnosis, early diagnosis, and early detection in CINAHL. Included studies were published in 2014 or later.

Results

Tumor lysis syndrome causes hyperkalemia, hyperphosphatemia, hypocalcemia, and hyperuricemia. These laboratory disturbances can lead to potentially destructive complications including renal injury, arrhythmias, seizures, and neuromuscular instability.

Discussion

Acute and critical care nurses can use disease-related risk factors and clinical presentations associated with these laboratory derangements to determine the level of monitoring and intervention necessary for impacted patients.

Conclusions

Knowledge of risk factors and clinical presentations will enhance the ability of nurses in clinical practice to prevent adverse events and complications that result from tumor lysis syndrome.
Active Surveillance of Low-Risk Papillary Microcarcinoma of the Thyroid in Indian Scenario
Authors: Mahajan Abhishek , Suryavanshi Shubham , Shukla Shreya , Vaish Richa , Agarwal Ujjwal , D’Cruz Anil
Published: June 2022

Papillary microcarcinoma (PMC) is defined as papillary thyroid carcinoma (PTC) measuring ≤1 cm, irrespective of the presence or absence of the high-risk features. PMCs without any high-risk features referred to as the low-risk PMCs are generally indolent, and most of them remain latent without progression or with very slow progression. Active surveillance (AS) (observation without immediate surgery) could identify the small minority of PMCs that progress and rescue surgery for these PMCs should be effective resulting in no influence on the patients’ prognosis than performing immediate surgery which might result in more harm than good due to associated morbidity. Hence, with proper patient selection, organization, and patient counseling, AS has the potential to be a long-term management strategy for patients with PMC. The recent update of the American Thyroid Association guidelines (2015) incorporated AS as an option within the management protocol of PTC, making it a considerable rather than an experimental treatment option. The cost for immediate surgery is higher than the medical costs of AS for 10 years in most scenarios. Developing countries like India may have certain limitations such as lack of understanding, financial constraints, and lack of adequate radiology services, hence we propose additional recommendations along with standard surveillance strategy.
Histopathological Evidence of Thyroid Dermopathy and its Correlation with Thyroid-Associated Orbitopathy in Patients with Graves’ Disease having Normally Appearing Pretibial Skin
Authors: Mishra Abhijit , Chakraborty Partha Pratim , Jana Sayantan , Saha Tarak Nath , Roy Krishnendu
Published: June 2022

Objective:

Thyroid dermopathy (TD), reportedly encountered in less than 5% of patients with Graves’ disease (GD), is supposed to coexist only with thyroid-associated orbitopathy (TAO). However, clinically inapparent TD, detected non-invasively by thermal imaging or ultrasonography, seems to be present in a larger proportion of GD. Histopathological examination (HPE), though considered as gold standard for detecting TD, has not been performed widely to identify subclinical TD in GD.

Materials and Methods:

In this single-centre, cross-sectional, case-control study, 50 patients with GD (cases) and normal appearing pretibial skin were compared with 45 age- and sex-matched individuals (39 healthy volunteers, 3 with toxic multinodular goitre and 3 with solitary toxic nodule) (control). All patients were evaluated clinically for presence of TAO. Punch biopsy specimens were obtained from the pretibial skin in all 95 participants. Tissue sections were examined under light microscopy for mucin deposition, splitting of collagen fibrils and perivascular lymphocytic infiltration.

Results:

Sixty per cent of patients with GD demonstrated at least one of the above three histological features, while 52% had any combination of two features and 46% harboured all the three features. Mucin deposition, splitting of collagen fibrils and lymphocytic infiltration were found overall in 52%, 54% and 52% of GD, respectively; 4.4–11.1% of controls also had some evidence of TD on HPE. Subclinical TD was not related to age, duration of disease and TAO in our study.

Conclusions:

TD, particularly in its subclinical form, Seems to be widely prevalent in GD (46–60%) and exists even in absence of TAO. HPE, though more sensitive than the various non-invasive tests, is not specific (ranges from 89% to 95%) for TD. However, HPE can accurately diagnose TD in appropriate clinical background.
Effect of Motivational Enhancement Therapy and Behavioral Couple Therapy in Subjects of Alcohol Dependence Syndrome
Authors: Kumar Saurav , Srivastava Mona , Srivastava Manushi , Yadav Jai Singh , Prakash Shiv
Published: June 2022

Background:

Alcohol dependence is a wide and extending social and physical problem in the world. It affects a person at the individual, family, and society levels. The aim is to study and compare the influence of motivational enhancement therapy (MET) and behavioral couple therapy on the level of motivation in a person with alcohol dependence.

Methodology:

Pre- and post-test with control group design was used. A total number of 60 subjects were selected using a purposive sampling method. The sample comprised twenty subjects in the behavioral couple therapy treatment as usual (Behavioral couple therapy BCT + TAU) group, twenty subjects in the control (TAU) group, and twenty subjects in the (MET + TAU) group, respectively. The subjects recruited were in the age range of 21–60 years, educated up to primary level and above, with no comorbid psychiatric, neurological disorder, physical problem, multiple substance use coming to outpatient department and inpatient department Department of Psychiatry IMS, BHU, Varanasi, and wife having age above 18 years, married for at least 1 year, educated up to primary level and above. Tools: sociodemographic datasheets, alcohol use disorder identification test, general health questionnaire-12, and stages of change readiness and treatment eagerness scale were utilized.

Results:

Psychotherapeutic intervention such as MET and behavioral couple therapy plays an effective role in raising motivation to change in alcohol-dependent person to quit alcohol, which is indicated by the significant rise in motivation for the change of alcohol-dependent person's recognition (F = 4.42, P < 0.05) and taking steps (F==3.78, P < 0.05).

Conclusion:

The present study suggests that combining pharmacological treatment with appropriate psychosocial therapies give fruitful result in the form of a desire to quit alcohol dependence.
Prevalence and risk factors of vulvar dermatoses
Authors: Mundhe Ashwini Dattatray , Jadhav Avinash , Deo Kirti , Deora Mahendra Singh , Gaikwad Rohini , Shinde Rajendra C.
Published: June 2022

Background:

The overall prevalence of vulvar diseases in the literature is low because of underreporting and is often neglected; thus, its impact on a female's life is often underestimated.

Objectives:

This study is aimed to determine the prevalence of vulvar diseases and their associated risk factors in patients attending a tertiary care hospital.

Materials and Methods:

This is a descriptive, cross-sectional, and case–controlled study wherein all female patients attending the dermatology outpatient department (OPD) were screened for the signs and symptoms of vulvar dermatoses and were enrolled after obtaining informed consent and institutional ethics committee approval for 21 months. Out of them, 200 patients who consented and had signs and symptoms of vulvar diseases were selected as cases, and the same number of age-matched females were enrolled as controls with no signs and symptoms of vulvar dermatoses.

Results:

During the study period, 9431 females attended the dermatology OPD, of which the prevalence was 2.12% (200 patients). The most common infection was genital infection without sexually transmitted infection (57%) (tinea cruris [33.5%]), followed by inflammatory dermatoses (21%) (lichen sclerosus et atrophicus [6%]). The most common risk factor found statistically significant (P ≤ 0.005) were homemakers (49%) and the use of undergarments of mixed fabric (70.68%), followed by nonmenopausal females (63.15%).

Conclusion:

Our study findings indicated that the prevalence was low, which reflects the tip of an iceberg. Further clinical and population-based studies, a multidisciplinary approach including gynecological consult for diagnostic and therapeutic approach is needed for the optimal management of vulvar diseases.
Intracranial lymphoma in human immunodeficiency virus-infected patients
Authors: Harjani Rajkumar Gurubuxrai , Hinduja Ritika Harjani , Iyer Asha Krishnaraj
Published: June 2022

Primary central nervous system (CNS) lymphoma is an aggressive malignancy which constitutes one of the acquired immunodeficiency syndrome -defining illnesses. Early diagnosis and timely management can increase the chances of cure. Although many times the diagnosis is straightforward, we present a case of primary CNS lymphoma in a human immunodeficiency virus--positive individual which posed as a major diagnostic dilemma with initially normal imaging findings. A 42-year-old male presented with unremitting fever and a perianal ulcer for 3 months. A battery of diagnostic tests were negative, including a positron emission tomography-computed tomography scan and a magnetic resonance imaging brain. With unresolving symptoms and a high index of suspicion as he developed dizziness and loss of balance, the same were repeated which confirmed a space-occupying lesion in the cerebellum. Although treatment was instituted, the patient did not recover and died in the 4th month of treatment.
A study on clinical spectrum of lichen sclerosus in a tertiary care Centre in North India
Authors: Brar Sukhmani Kaur , Bano Rubeena , Puri Neerja , Singh Amarbir
Published: June 2022

Introduction:

Lichen sclerosus (LS) is a chronic dermatosis frequently located over labial, perineal, and perianal areas. The etiology is multifactorial and includes genetic, autoimmune, hormonal, and infectious aspects.

Materials and Methods:

A series of twenty genital LS patients was carried out to evaluate the signs, symptoms, complications, and affliction of quality of life.

Results:

Eighteen out of twenty patients were female between 30 and 73 years and showed smooth, glistening, and whitish plaques. The mean duration was 8.4 years. Itching and burning was the most common symptom (75%) corresponding to excoriation and fissuring of genitalia (75%). Malignancy was seen in two cases (10%). The mean Vulvar Quality of Life Index was 9.2, higher in younger patients.

Discussion:

LS is a disorder of older age group with female preponderance. It is a source of significant morbidity, and long-standing cases predispose to vulvar malignancy.

Conclusion:

To conclude, early diagnosis with proper counselling of the patient and his/her partner regarding various aspects of disease are essential for a wholesome approach.
Logistic regression-based parametric analysis of HIV-associated dementia using a screening tool in a tertiary care hospital in Mumbai
Authors: Joshi Kavita Sanjeev , Ambardekar Pranav Milind , Gujarathi Rushabh Yatish , Natu Anuya Ajit , Churiwala Widhi , Rajapurkar Nehar Dilip
Published: June 2022

Context:

The AIDS dementia complex is one of the most common and clinically important complications of HIV infection. Subclinical dementia not presenting with features of frank disease may be missed. The use of screening tools provides a good alternative to a psychiatrist's diagnosis in resource-limited settings like the site of this study.

Aims:

The study aimed to analyze various parameters such as age, gender, duration of the disease, duration since treatment, clinical staging, CD4 count, mode of transmission, and comorbidities like tuberculosis with the prevalence of AIDS dementia complex in the participants.

Settings and Design:

A cross-sectional study involving 180 participants was conducted over a duration of 18 months.

Materials and Methods:

The assessment of dementia was done using the International HIV Dementia Scale.

Statistical Analysis Used:

Backward binomial logistics regression.

Results:

Both duration of treatment and duration since diagnosis of HIV were found to be significantly associated with the presence of AIDS dementia. Patients having stage 4 disease and CD4 counts <200 were likelier to have dementia as compared to other participants. People with an unknown mode of transmission had higher odds of having AIDS dementia than persons having a mode of transmission as via blood/blood products/invasive procedures/mother-to-child transmission/IV drug abuse. Binomial logistic regression revealed mode of transmission or rather its awareness to be the strongest contributor.

Conclusions:

These findings highlight the need for early screening and diagnosis of HIV-associated dementia in patients living with HIV and that of early assessment and initiation of treatment.
Case Report: Chemoradiation with Paclitaxel and Carboplatin Unveiling Leprosy Type 1 Downgrading Reaction
Authors: Savitha B , Sardana Kabir , Khurana Ananta , Rani Seema , Sachdeva Soumya , Ahuja Arvind
Published: June 2022

Type 1 lepra reaction (T1R) is a major complication seen in nonpolar forms of leprosy and leads to significant morbidity. The classification of T1R as up and downgrading, based on previously defined histopathological criteria (by Ridley), has therapeutic and prognostic implications. The trigger factors for these reactions are poorly described, especially in case of downgrading T1R and we describe a case of leprosy reaction that was possibly triggered by chemoradiation and elucidate the possible mechanism.
Estimating the prevalence of paediatric chronic pain in Switzerland: an online survey among paediatricians
Authors: Koechlin Helen , Locher Cosima , Carlander Maria , Kossowsky Joe , Woerner Andreas , Dratva Julia
Published: June 2022

BACKGROUND: Chronic pain is a frequent complaint in children and adolescents, with great international variation in prevalence. Paediatricians are usually the first-line contact for pain problems in children and might refer patients to other specialists or pain clinics where available. Prevalence estimates of paediatric chronic pain and paediatricians’ care experiences in Switzerland are currently lacking. OBJECTIVES: The aim of this study was to assess the prevalence of paediatric chronic pain in Swiss paediatrician practices and paediatricians’ professional experience and confidence with, and care provision for patients with paediatric chronic pain. METHODS: Data were collected in 2019 using a cross-sectional online questionnaire among Swiss paediatricians. Ordinary least square regression analyses and Monte Carlo simulations were applied to estimate the prevalence rate of paediatric chronic pain. Explorative multivariate logistic regression analyses investigated whether sociodemographic and professional factors were associated with paediatricians’ confidence in treating and experience with paediatric chronic pain. RESULTS: We included 337 paediatricians in our anonymised analyses. The prevalence rate of paediatric chronic pain in our sample was estimated to be between 2.54% and 3.89%. Twenty percent of paediatricians reported feeling confident in treating paediatric chronic pain, 77.2% had referred patients with paediatric chronic pain to another specialist and more than half had at least some experience with paediatric chronic pain. Experience and confidence with treating paediatric chronic pain were associated with male gender. CONCLUSION: Our study is the first to estimate the prevalence of paediatric chronic pain by means of a sample of Swiss paediatricians. The prevalence rate was considerably lower than other estimates. Given the lack of training and confidence with treating paediatric chronic pain reported by paediatricians, absence of awareness and resulting under-diagnosis is possible.
Assessment of Lime Stabilized Soils Modified with Egg Shell Ash for Road Construction
Authors: Adeyemi E. Dr. Adetoro , Akinkunmi S. Dr. Oladapo , Ilesanmi O. Olofintuyi
Published: June 2022

The need to have in-depth knowledge about the Engineering properties of soil and the sub-soil condition for road construction especially in the southwestern Nigeria brought about this study. Some strength properties (California Bearing Ratio (CBR), Compaction, Unconfined Compressive Strength (UCS), and direct Shear tests) of lime stabilized soils modified with Egg Shell Ash (ESA) were assessed. Soil samples were obtained from each state in the study area and transported to the laboratory, where they were stabilized with 6% lime and 0 to 10% ESA before the above-mentioned tests was conducted on them. The local additive was also subjected to a chemical analysis. Results showed that ESA additive has low SiO2 and high CaO compounds. Increase in ESA resulted in increase of all the strength properties (Maximum Dry Density (MDD), CBR, UCS, Cohesion (C), Shear strength (S) and Angle of Internal Friction (ϕ)) and reached peak at 8% ESA, thereafter decrease; albeit, Optimum Moisture Content (OMC) decreases. After the improvement process, almost all the unsuitable soil samples became suitable for use as pavement layer materials. Consequently, a blend of 6% lime and 8% ESA content is recommended for soil improvement, especially for road pavement layers in southwestern Nigeria.
Analysis of Marketing Strategy and Successful Leadership in a Case of Hyundai Motor Company
Authors: Hieu Le Quang , Trang Truong Dinh
Published: June 2022

Hyundai leads the automobile industry and has made very positive contributions to the overall achievements of economic and social values. Kang et al (2014) pointed In constructing global marketing strategy, Hyundai Motor’s vision is "Lifetime partner in mobility and beyond" and its goal is global top 3 brand by year 2015 through modern premium brand image and selling 5 million vehicles. The target brand positioning of Hyundai Motor is the leading position in premium dimension and stylish/modern dimension. The global brand strategy framework is based on the brand direction of "Modern Premium" and is designed to deliver core brand identity (i.e., Simple, Creative, Caring) to customers. Its marketing strategy shows us: - Hyundai's product strategy is to standardize technical standards with the ambition of being a global product, ensuring the best quality, aiming at the recognition of the value of the customer's product, satisfying the customer's needs. On the other hand, Sale activities is placed at showrooms, though sale agents, and sale person team. Beside, according to the results of quantitative research, in a multi-factor model, we would suggest the government, Ministry of Finance and State Bank: control inflation properly, and firm management control cost properly (as reduction in cost and CPI will cause net profit to increase).
Strategy for Industrial Clusters in Hanoi Vietnam and Matters of Protecting Consumer Interests
Authors: Diep Nguyen Trong , Trung Nguyen Dinh , Huy Dinh Tran Ngoc
Published: June 2022

First we recognize we need to have consistent overall planning of clusters. The planning and development of industrial zones has not been determined on a balanced basis by industry and region. This is the main cause of the weakness in the development of social infrastructure for the development of industrial zones. Second, we need suitable training programs qualified for laborers and select professional advisers for proper projects. Last but not least, we need adding "product" in the concept of "goods and services" (to "products, goods and services” to ensure adequate adjustment of all stages of the business process - consumption as well as not omitted for new objects arising in business processes such as digital services and digital products. Also, Adding new regulations on international cooperation in dispute settlement disputes between consumers and foreign organizations and individuals, in which, principles of cooperation, scope of cooperation between consumer protection agencies used in countries.
Green synthesis of silver nanoparticles using common poppy (Papaver rhoeas L.) and evaluation of their potential antibacterial activity
Authors: Dikbas Cigdem , Yavuz Oguzhan , Ay Hilal , Andac Muberra
Published: June 2022

Due to their easy and low-cost production and enhanced properties, noble metal nanoparticles are preferred as nano-additives in most pharmaceutical compositions. For example, silver nanoparticles (AgNPs) and gold nanoparticles (AuNPs) possess antiseptic and antimicrobial activity and they are generally preferred for obtaining antibacterial clothing and coatings. In the present study, we report a simple, low cost and green method for synthesizing AgNPs using aqueous extracts of common poppy (Papaver rhoeas L). Synthesised silver nanoparticles were characterised based on Field Emission Scanning Electron Microscopy equipped with energy dispersive X-ray spectroscopy, Fourier-Transform Infrared Spectroscopy, and X-ray diffraction analysis. The synthesised AgNPs were also tested for antimicrobial activity using the agar well diffusion method. Characterisation methods showed that the obtained AgNPs were spherical in shape, with a particle size ranging from 15 to 40 nm. According to the antimicrobial test results, AgNPs effectively inhibited the growth of various gram-positive and gram-negative bacteria. It was concluded that Papaver rhoeas L. extract is effective as a reducing agent for the preparation of stable and monodispersed AgNPs and obtained AgNPs could be useful in antibacterial applications in human and veterinary medicine.
Advanced Patient Monitoring System with Diseases Prediction System using Machine Learning
Authors: C Udhayakumar , S Ashik , S Bala Subramaniyan , K Dharanishan , A Ganeshraja
Published: June 2022

IoT and machine learning (ML) are becoming increasingly efficient in the medical and telemedicine areas all around the world. This article describes a system that employs latest technology to give a more accurate method of forecasting disease. This technology uses sensors to collect data from the body of the patient. The obtained sensor information is collected with NodeMcU before being transferred to the Cloud Platform "ThinkSpeak" through an ESP8266 Wi-Fi module. ThinkSpeak is a cloud server that provides real-time data streams in the cloud. For the best results, data currently saved in the cloud is evaluated by one of the machine learning algorithms, the KNN algorithm. Based on the findings of the analysis and compared with the data sets, the disease is predicted and a prescription for the relevant disease is issued.
Psoralen Promotes Myogenic Differentiation of Muscle Cells to Repair Fracture
Authors: Cui Zhenhai , Huang Tingrui , Huang Chen , Zhao Wenhai , Chen Jianming , Tang Dezhi
Published: June 2022

Myogenic differentiation requires to be exactly explored for the effective treatment of fracture. The speed of healing is affected by skeletal muscle, linked to activation of specific myogenic transcription factors during the repair process. In previous study, we discovered that psoralen enhanced differentiation of osteoblast in primary mouse. In the current study, we show that psoralen stimulates myogenic differentiation through the secretion of factors to hone the quality of repair in fractured mice. 3-month old mice were treated with corn oil or psoralen followed by a tibial fracture surgery. Fractures were tested 7, 14, and 21 days respectively later by histology and images observation. Skeletal muscles including soleus muscle and posterior tibial muscle around the damaged bone were collected for quantitative real-time PCR, HE staining, as well as western blot. Daily treatment with psoralen at seven, fourteen days or twenty-one days improves protein or mRNA levels responsible for the whole myogenic differentiation process, makes the muscle fibers more tightly aligned, and promotes callus formation and development. This data shows that high levels of myogenic transcription factors in the process of fracture healing in mice foster the repair of damaged muscles, and indicates a pharmacological approach that targets myogenic differentiation to improve fracture repair. This also reflects the academic thought of "paying equal attention to both muscles and bones" in the prevention and treatment of fracture healing.
Análisis de los #DanceChallenge en Tiktok mediante la Metodología Visual Crítica
Authors:   Universidad Nacional Autónoma de México,  México, González Marissa
Published: June 2022

En este artículo exploramos las potencialidades de la metodología visual crítica (Rose, 2016) para el estudio de videos breves y verticales en TikTok. Se presentan 5 estudios de caso en los #dancechallenge más populares durante el 2021 en México #Tododetichallenge #Dakitichallenge, #Bichotachallenge, #Callatuchallenge y #Levitatingchallenge. En la primera parte de este artículo se expone de forma breve el surgimiento y consolidación de la aplicación china TikTok, sus funcionamiento, la caracterización del tipo de usuarios que utilizan la plataforma y sus cifras alrededor del mundo. En la segunda, se exponen de forma breve los problemas prácticos en la recopilación de datos y en la representación visual para el análisis de este tipo de materiales en la aplicación. Finalmente, se presentan los resultados del análisis de los materiales visuales de TikTok en su inserción en el mundo social en los cuatro sitios de acuerdo a la metodología visual crítica: el lugar de la producción, el lugar de la imagen, el lugar de la circulación y el lugar de la audiencia.
Selection of Candidate for a Project Using WASPAS Method
Authors: Venkateswaran C , Pavithra V , Ramachandran M , Selvam Manjula
Published: June 2022

In this from analysis EDAS method is the most ideal solution Short-distance and negative-best The solution with the longest distance from the solution Determines, but the comparison of these distances Does not consider importance. From the result it is seen that BS4 is got the first rank where as is the BS5 is having the lowest rank. In this look at, the compatibility of the Weighted Total Product Assessment (WASPAS) technique is explored as an effective MCDM tool, while solving 8 manufacturing choice-making issues such as slicing fluid, electroplating device, fraud degree, arc welding approach, and business robot. , Grinding degree, mechanical efficiency of substances and electro-discharge micro-machining technique parameters. This machine has the ability to as it should be rank options in all exam issues taken into consideration. An creation to the WASPAS approach is given inside the ‘WASPAS technique’ segment In the 'Risk Identification and Criteria Weights' phase, threat evaluation and numerical example 'vicinity' chance analysis is finished thru a case examine of a street manufacturing mission in Iran. In the 'Discussion' phase, the cautioned approach is in evaluation with exclusive studies and the findings and the effects of the proposed technique are noted. In this paper, we used the Project WASPAS approach. We take oral communication skills (C1), personality (C2), past experience (C3), self-confidence (C4) and hierarchical structure (C5) the hierarchical shape is the assessment parameter. BS1, BS2, BS3, BS4, BS5 are options. FIGURE 3 Shows that From the BS4 it is seen that BS4 and is got the first Score whereas is the BS5 got is having the lowest Score.
METHODOLOGY FOR DEVELOPING AND RANKING THE ENVIRONMENTAL DEVELOPMENT OF THE REGIONS OF THE REPUBLIC OF BELARUS
Authors:   Central Research Institute for Complex Use of Water Resources, Dubianok Sniazhana A. , Kulakou Andrei Ju. ,   Central Research Institute for Complex Use of Water Resources, Kononchuk Tatyana P. ,   Ministry of Natural Resources and Environmental Protection of the Republic of Belarus
Published: June 2022

The development of a rating for the environmental development of the regions of the Republic of Belarus is conditioned by the necessity of a comprehensive assessment of the environmental state of the country’s regions for the implementation of the state policy of the country in the field of sustainable development and improvement of environmental quality, as well as for increasing the efficiency of application of environmental instruments in the framework of international cooperation. Based on the analysis of international approaches to the formation and use of various environmental ratings, the concept of the rating of environmental development of the regions of Belarus at the level of administrative-territorial units (regions) and large cities (regional centers and the city of Minsk) has been developed, scientific and methodological approaches to the formation and maintenance of rating of ecological development. The ranking methodology is based on the ranking of regions according to a set of indicators grouped into three categories. For the rating of cities, 31 indicators were determined, for regions - 37 indicators, which allow for a comprehensive assessment of the current state of the components of the natural environment, the impact of the main types of economic activity on the environment and issues of the effectiveness of environmental policy at the regional level. The methodology for the rating of ecological development of regions was formalized in 2021 in the form of a technical regulatory legal act - TCP 17.02-19-2021 «Environmental Protection and Nature Management. Rating of ecological development of regions of the Republic of Belarus. Technical requirements». Scientific, methodological and practical support for the functioning of the rating of ecological development of regions will be carried out by the Ministry of Natural Resources and Environmental Protection of the Republic of Belarus. An annual update of the rating of regions and cities of the Republic of Belarus and the publication of rating data are provided. In 2021, RUE «Central Research Institute for Complex Use of Water Resources», based on the developed methodology, created the information resource «Ranking of the Environmental Development of the Regions of the Republic of Belarus», which allows automating the procedure for calculating the rating of the ecological development of the regions of Belarus, and calculated and compiled the environmental rating for 2020 year in the context of regional centers and the city of Minsk, the results of which are given in the article.
STRUCTURAL CATEGORY «OLYMPIC EDUCATION» IN THE DIGITAL PORTFOLIO «ORGANIZATION OF EXCURSION WORK»
Authors:   BSPU M.Tanka, Vertejko O. V. , Borisevich A. R. ,   BSPU M.Tanka
Published: June 2022

The development of the information society enables the scientific community to formulate and develop new areas of activity to improve the organization of work, including the educational process for sustainable development. The transition to distance learning makes it possible to get information from different sources, to maximize the saturation of the educational summary of lectures with multimedia presentations and hyperlinks to important events. The developed structural heading is aimed at achieving the goal: it is aimed at creating and maintaining a patriotic, civil image of the Republic of Belarus on the basis of glorifying our Olympians, high-level athletes, athletes studying at the Faculty of Physical Education of the Belarusian State Pedagogical University named after Maxim Tank, as well as focusing on the small Homeland of each athlete, taking into account both the cultural and historical heritage of our state.
EXPERIENCE IN INTRODUCING SUSTAINABLE DEVELOPMENT IDEAS INTO ECONOMIC DISCIPLINES IN A GLOBAL PANDEMIC
Authors:   International Sakharov Environmental Institute, Belarusian State University, Kusina L. V.
Published: June 2022

The article examines the experience and challenges of integrating sustainable development into the learning process in the context of the coronavirus pandemic. Forced transition to distance learning required teachers to transform the entire learning process. The aim of the study is to analyze moodle experience using economic disciplines. The problems and successes of this process are analyzed, the contradictions between the traditional and remote form of education are shown. It is concluded that the possibilities of educational online content contribute to the accumulation, improvement and use of the database of electronic resources related to environmental issues. The inclusion of these resources in the content of economic disciplines contributes to the saturation of the software material with environmental aspects and key issues of sustainable development.
EFFECIENCY AND CULTURE OF NATURE MANAGEMENT: HISTORICAL, RESOURCE, NOOSPHERIC AND MEDICAL-ECOLOGICAL SCIENTIFIC APPROACHES
Authors:   Institute of Geography of the Russian Academy of Sciences, Kochurov B. I. , Chernaya V. V. ,   Ryazan State Medical University, Bakovetskaya O. V. ,   Ryazan State Medical University, Pominchuk Y. А. ,   Ryazan State Medical University
Published: June 2022

The author’s article reflects the current trends in the development of scientific, theoretical and applied areas of modern environmental management. The article presents a hypothesis about the driving forces of human society and the reasons for the appearance of changes in new resources, an analysis of the environmental consequences of the development of human society and the justification of the noosphere approach in nature management. The conclusion is justified that the evolutionarily directed process of changing human society should take place within the strict framework of the “eco-policy of containment” and “green diktat”, through strengthening the efficiency of nature management and the culture. Changes in consumer stereotypes, an increase in the number of “green” industries, the development of green agriculture, ecotourism and medical and environmental researches are extremely important; reorientation of the population’s life attitudes from consumer to socio-spiritual (implementation and compliance with the Code of Nature Management Culture).
ECOLOGICAL EDUCATION IN THE SCHOOL-UNIVERSITY SYSTEM TO REALIZE THE GOALS OF SUSTAINABLE DEVELOPMENT IN PRACTICE-ORIENTED LEARNING
Authors:   International Sakharov Environmental Institute, Belarusian State University, Chernetskaya A. G. , Strigelskaya N. P. ,   International Sakharov Environmental Institute, Belarusian State University, Malinovskaya Y. V. ,   International Sakharov Environmental Institute, Belarusian State University, Schastnaya E. V. ,   State educational institution “Gymnasium No. 38 of Minsk”
Published: June 2022

The article reveals the problems of the Belarusian school associated with an insufficient level of practical orientation of the educational process in biology and ecology. The main goal of a practice-oriented approach in education is to build an optimal model that combines the use of theoretical knowledge in solving practical issues related to the formation of a specialist’s professional competencies. Formation of a unified educational environment between schools and universities of our republic is effective for solving this problem. An example of such interaction is the work of the educational and methodological laboratory of environmental education of the International Sakharov Environmental Institute of Belarusian State University.
FEATURES OF DISTANCE TEACHING PHYSICAL AND MATHEMATICAL DISCIPLINES FOR STUDENTS FIRST COURSE OF ECOLOGICAL SPECIALTIES
Authors:   International Sakharov Environmental Institute, Belarusian State University, Chikova T. S. , Borbotko E. P. ,   International Sakharov Environmental Institute, Belarusian State University, Radziuk D. I. ,   International Sakharov Environmental Institute, Belarusian State University, Fedorenchik E. P. ,   International Sakharov Environmental Institute, Belarusian State University
Published: June 2022

The article analyzes the main problems of distance teaching of physics and mathematics courses to first-year students of environmental specialties. The ways of overcoming them with the use of various systems and resources of electronic support of students ‘ education are considered. It is shown that the success of solving didactic tasks is determined by the choice of effective pedagogical technologies and the use of the most suitable telecommunications and information educational platforms for their implementation.
LANDSCAPE THERAPY AS A MODERN METHOD OF LANDSCAPE DESIGN
Authors:   International Sakharov Environmental Institute, Belarusian State University, Chernetskaya E.I. , Lukyanchuk A.G. ,   International Sakharov Environmental Institute, Belarusian State University
Published: June 2022

Landscape therapy is a method of spa therapy aimed at improving the health of the body by the influence of the beauty of nature, landscapes and therapeutic walks. Scientific studies show that unity with nature helps to reduce the level of anxiety, relieve stress, and even reduce high blood pressure. Contemplation of the beauty of nature stimulates the vitality and calms the nervous system, provides positive emotions. The article provides an overview of the use of medical gardens to improve the health of people in the countries of Europe and the East. The necessity of landscape therapy on the territory of Belarus is also justified.
SOCIAL TECHNOLOGIES OF LANGUAGE AND PROFESSIONAL TRAINING OF SPECIALISTS IN THE SPHERE OF ECOLOGICAL SAFETY TAKING INTO ACCOUNT INSTITUTIONAL DISCOURSE
Authors:   International Sakharov Environmental Institute, Belarusian State University, Kovaleva T. G.
Published: June 2022

The report is devoted to the problem of technologization of the process of professionally oriented teaching of a foreign language to future specialists in the field of nuclear and radiation safety. It is proposed to take into account the characteristics of the institutional discourse in the field of radiation safety when developing social technologies (debates, situational miniatures, discussions).
ANALYSIS OF THE LONG-TERM DYNAMICS OF THE EPIDEMIC PROCESS OF AEROSOL INFECTIONS IN THE REPUBLIC OF BELARUS
Authors:   International Sakharov Environmental Institute, Belarusian State University, Basyakova O. S. , Porada N. E. ,   International Sakharov Environmental Institute, Belarusian State University
Published: June 2022

Infectious diseases have ceased to determine the epidemiological situation in the republic, but they still remain an important problem. Aerosol infections account for about 95% of the infectious diseases registered annually in the republic. Among them there are such nosological forms as pertussis, meningococcosis, morbilli, rubella [2] which are more common in the childhood and even with a low incidence rate represent an important medical and social problem. The wide spread of aerosol infections and the ease of their acquisition require constant epidemiological surveillance and control, and, therefore, respiratory tract infections remain a major public health problem and do not lose their relevance. In the paper there have been analyzed the long-term dynamics of the morbidity of the population of the Republic of Belarus with aerosol infections, controlled, partially controlled and uncontrolled by means of immunoprophylaxis, in the period from 1995 to 2019 yrs. There have been determined the territorial features of the infectious epidemic process appearance with the use of GIS technologies.
SOME SOCIO-PSYCHOLOGICAL ASPECTS OF COVID-19 PANDEMIC’S IMPACT ON THE QUALITY OF PEOPLE’S LIFE
Authors:   International Sakharov Environmental Institute, Belarusian State University, Luchina V. N. , Sivukha V. V. ,   International Sakharov Environmental Institute, Belarusian State University
Published: June 2022

To date, there is a wide range of research in Asia, America and Europe on the “first wave” of the COVID-19 pandemic. These studies prove that the main negative factors affecting the mental and somatic health of people include measures of social distancing. In most countries of the world, in order to reduce the burden on the health system, quarantine was introduced. The decrease in social contacts of people due to forced self-isolation caused some psychological problems such as loneliness, stress, fear, apathy. Also, the issue of professional burnout among medical personnel working with COVID-infected patients in conditions of extreme stress and the threat of infection is relevant.
COMPARATIVE ANALYSIS OF THE VISUAL ENVIRONMENT OF THE CITY OF MINSK AND MINSK REGION THROUGH SPECIALIZED SOFTWARE
Authors:   International Sakharov Environmental Institute, Belarusian State University, Kozelko N. A.
Published: June 2022

Currently, more than half of the world’s population lives in cities. Urbanization has brought about significant changes in modern human life. However, these processes are not always positive. The visual environment is an important environmental factor that is overlooked by many modern people. To analyze the state of the visual environment of the Minsk region and the city of Minsk, a questionnaire was developed, as well as specialized software «ЭкоВид-2020».
TOXICOLOGICAL EVALUATION OF AN EQUIVALENT MIXTURE OF PROTIOCONAZOLE AND TEBUCONAZOLE IN ANIMALS
Authors:   Scientific-practical center of hygiene, Kutliahmetov I. F. , Atroshko M. A. ,   International Sakharov Environmental Institute, Belarusian State University, Gomolko T. N. ,   Scientific-practical center of hygiene
Published: June 2022

This publication presents modern approaches to the assessment of toxicological characteristics of combined agricultural preparations.
EFFECT OF HEATING ON THE DISTRIBUTION OF ZOOBENTHOS BIOMASS IN THE LUKOMLSKAYA GRES COOLING POND
Authors:   Scientific and Practical Centre of the National Academy of Sciences of Belarus on Bioresources, Lapuka I. I.
Published: June 2022

The change of zoobenthos biomass in the different depths of the heated and non-heated water area in summer and autumn was studied. It was found that the total biomass was lower in the heated water area. The biomass was changed by depth in the lake and had the same view at the different seasons and different thermal load: from shallow water to a certain depth, and then declined to the bottom.
ANALYSIS OF PECULIARITIES OF RELATIONSHIP OF DIFFERENT TEMPERATURE TYPES TO GLOBAL ENVIRONMENTAL PROBLEMS
Authors:   International Sakharov Environmental Institute, Belarusian State University, Nikitenko A. A. , Kozelko N. A. ,   International Sakharov Environmental Institute, Belarusian State University
Published: June 2022

Currently, scientists attach great importance not only to the development of new methods to improve the environmental culture of an individual, but also to the possibility of preventing indifference to environmental problems. However, in order to develop methods for improving the ecological culture of an individual, it is necessary to know the basics of its formation. Such a basis can be the knowledge of how the type of temperament affects the attitude of the individual to global environmental problems. The negative features typical to this temperament, their negative impact on the development and social adaptation of an individual and insufficient knowledge in modern psychology of the influence of temperament on the attitude of the individual to global environmental problems determine the relevance of this study.
THE EFFECT OF CREATINE AS DIETARY SUPPLEMENT ON GENOMIC INSTABILITY OF MONONUCLEAR CELLS OF PERIFERAL BLOOD AND HEPATOCYTES OF RATS IMPACTED BY X-RAY RADIATION
Authors:   Institute of Molecular Biology of NAS RA, Petrosyan M. S. , Nersesova L. S. ,   Institute of Molecular Biology of NAS RA
Published: June 2022

The effect of creatine (Cr) as a dietary supplement (creatine monohydrate in a 0.9% glucose solution per os at the 1g/kg of rat weight dosage, for two weeks prior to and two weeks after the irradiation) on the post-radiation DNA damage of peripheral blood mononuclear cells and the distribution disorders per rats’ hepatocyte ploidy, induced by the total one-time irradiation in the dosage of 4,5 and 6.5 Gy, has been studied. The results have demonstrated that Cr has a protective effect per the parameters observed, which helps reduce the radiation-induced genomic instability of the respective cells, thus testifying to the radioprotective activity of Cr.
COMPARATIVE CHARACTERISTICS OF THE PSYCHOLOGICAL STATE OF SCHOOLCHILDREN STUDYING AT BOARDING SCHOOLS AND GYMNASIUMS
Authors:   International Sakharov Environmental Institute, Belarusian State University, Serenkova E. L. , Svirid V. D. ,   International Sakharov Environmental Institute, Belarusian State University
Published: June 2022

The level and nature of school-related anxiety in primary and secondary school-age children were analyzed. On the basis of boarding schools,the data that the level of anxiety in children of primary school age is within the normal range were obtained, and in subjects of secondary school age this indicator is slightly increased. In children studying in the gymnasium, the level of anxiety is within the normal range. Statistically significant differences in the level of school anxiety among children studying in boarding schools and high school students were revealed.
DIFFERENTIATION OF PINE GROWING IN WILD ROSEMARY AND POLYTRIC FOREST TYPES BY MORPHOLOGICAL-ANATOMIC PARAMETERS OF ANNUAL LAYERS
Authors:   Scientific and Practical Centre of The State Forensic Examination Committee of The Republic of Belarus, Khokh A. N. , Zviagintsev V. B. ,   Belarusian State Technological University
Published: June 2022

The article provides a comparative analysis of the morphological and anatomical structures of annual layers in the long moss pine forest (Pinetum polytrichosum) and the wild rosemary pine forest (Pinetum ledosum). It has been established that the radial diameter of the early and late tracheids and their cavities, the area of the cell wall and the area of the cavity of the early and late tracheids, as well as the number of late tracheids in the radial row of the annual layer can serve as markers for differentiating these forest types, even in spite of fairly similar conditions growth.
TENOFOVIR AS A POTENTIAL PROTEASE M INHIBITOR OF CORONOVIRUS 2019-nCoV
Authors:   International Sakharov Environmental Institute, Belarusian State University, Shahab S. N. , Vasyukevich E. N. ,   International Sakharov Environmental Institute, Belarusian State University
Published: June 2022

In 2019, a novel Coronavirus 2019-nCoV was found to cause Severe Acute Respiratory symptoms and rapid pandemic. In order to find candidate drugs for 2019-nCoV, we have carried out a computational study to screen for effective available drug Tenofovir which may work as inhibitor for the Mpro of 2019-nCoV.
TRIAZAVIRIN AS A POTENTIAL PROTEASE M INHIBITOR OF CORONOVIRUS 2019-nCoV
Authors:   International Sakharov Environmental Institute, Belarusian State University, Shahab S. N. , Vasyukevich E. N. ,   International Sakharov Environmental Institute, Belarusian State University
Published: June 2022

Triazavirin is a synthesized antiviral drug. It is being investigated for potential use against the 2019-nCoV coronavirus. In this study, the molecular structure of this molecule was investigated using the density functional theory (DFT/B3LYP/MidiX) in the gas phase. Molecular HOMO-LUMO orbitals, excitation energies, and oscillatory forces of the compound under study are also calculated and presented. The interaction of the Triazavirin compound with the Coronavirus was carried out by molecular docking.