bluuebunny/crossref_metadata_2025 huggingface dataset:
Untargeted metabolomic study of lung cancer patients after surgery with curative intent: possible metabolites of good prognosis, intervention failure and recurrence
Authors: Sánchez-Espirilla Saida , Vega Antonio Pereira , Callejón-Leblic Belén , Díaz-Olivares Isabel , Santana-Martín Rafael , Rivera Carolina Gotera , Gómez-Ariza José Luis , López-Campos José Luis , Blanco-Orozco Ana Isabel , Seijo Luis , Rodríguez María , Fraysse Luis Padrón , Herrera-Chilla Ángela , Peces-Barba Germán , García-Barrera Tamara
Published: January 2023

Background
Lung cancer (LC) is a leading cause of mortality claiming more than 1.8 million deaths per year worldwide. Surgery is one of the most effective treatments when the disease is in early stages. The study of metabolic alterations after surgical intervention with curative intent could be used to assess the response to treatment or the detection of cancer recurrence.
Methods
In this study, we have evaluated the changes in the metabolomic profile in serum samples (n = 110) from preoperative (PRE) and postoperative (POST) LC patients collected at two different timepoints (1 month - A; 3–6 months - B) with respect to a group of healthy people. An untargeted metabolomic platform based on reversed phase (RP) and hydrophilic interaction chromatography (HILIC), both mounted into an ultra-high performance liquid chromatography (UHPLC) coupled to mass spectrometry (MS) was applied.
Results
A total of 33 altered metabolites belonging to carboxylic acids, organooxygen compounds, prenol lipids, fatty acyls, glycerolipids and glycerophospholipids classes were annotated comparing all the different studied groups. We found a group of metabolites altered in PRE (gabaculine, DG(14:0/22:1), stearamide, proline and E,e-carotene-3,3'-dione) whose levels returned to those of a baseline control group 3–6 months after surgery. Furthermore, humulinic acid A and 3-galactosyllactose levels may predict an unsuccessful surgery because they remained altered after the intervention in some patients. In addition, tranexamic acid could be studied more exhaustively to be proposed for monitoring the postoperative recurrence of the LC because its levels seem to be close to controls after one month of the intervention, but may differ significantly after 3–6 months.
Conclusions
This study provides unique insights into the metabolic profiles of LC patients after surgery at two different time points with a wide metabolic coverage combining complementary analytical methods.
Bilateral local primary parotid gland amyloidosis, a case report and literature review
Authors: Abdelwahed Mohammed , Kawam Alae , Rosca Oana C.
Published: January 2023

Amyloidosis of the salivary glands is a rare occurrence. It is an extremely uncommon manifestation of systemic amyloidosis and an even less common manifestation of primary amyloidosis. Here, we present a case of an 80-year-old female with a history of rheumatoid arthritis who presented with bilateral parotid masses and ear pain radiating to the shoulders. Fine needle aspiration revealed a cellular specimen with no atypical features, with abundant amorphous material. On Diff-Quick preparation the amorphous material showed a deep blue, while on Pap stain it was brightly eosinophilic. A cell block was prepared and demonstrated characteristic staining with Congo red. The material displayed the typical birefringence under polarized light microscopy. This case is an example of a rare presentation of amyloidosis and demonstrates the utility of fine needle aspiration (FNA) for the diagnosis of amyloidosis.
Non-targeted metabolomic analysis of highland barley original powder and enzymatic hydrolysis powder (pullulanase combined with α-glucosidase)
Authors: li yan , Sun Kangna , Song Xiaofan , Chen Fuzhang , Yuan Zhenzhen
Published: January 2023

Highland barley was used as raw material to prepare slow-digested starch by double-enzyme enzymatic hydrolysis process. The non-targeted metabolomics method was used to analyze the correlation between the differences in metabolites of small molecules before and after double-enzyme enzymatic hydrolysis, and to explore the effect on the metabolism of highland barley starch after double-enzyme enzymatic hydrolysis. UHPLC-QTOF-MS detection showed that the main up-regulated metabolites and metabolic pathways in enzymolysis group were mainly flavonoids, and the main down-regulated metabolites and metabolic pathways were mainly lipid metabolism. The results showed that compared with the control group, the enzymatic hydrolysis group regulated the content of sugars and flavonoids in the enzymatic hydrolysis starch by affecting the metabolic pathways such as glycolysis and flavonoid production, thereby affecting the starch characteristics of the double enzyme enzymatic hydrolysis of highland barley flour and making it produce a more gentle blood glucose response in the human body.
Materials for outer shell of 1.170 GWh (1.00669 kilo ton TNT) fusion device - weight basis
Authors: Rafique Muhammad Musaddique Ali
Published: January 2023

With recent developments in fusion engineering, interest has sparked in development of fusion devices for deterrent. Enormous amount of energy generated by combining two light nuclei could be contained and manipulated at will to trigger and accelerate micro explosions (from shock wave, x-rays or ion beam focusing) which finally result in full scale blast. Materials required to make such device are critical. They must possess high strength, high hardness, ductility, formability, drawability, and anisotropic properties. High entropy alloys (HEA) are new class of materials which nicely fulfils this requirement. Essentially, they are solid solutions of multi principal elements (usually > 5) eliminating the need of base metal as in conventional alloys. This gives them many unique properties which may be tailored at will (heat treatment, cold rolling, precipitation, irradiation). They also exhibit excellent directional properties with formation of distinct bands along certain preferred crystallographic planes even in hexagonal close packed structures. These anisotropic properties are strong function of rolling, working, or forging (swaging) direction and can be utilized to benefit. This study encompasses making outer shell of a typical fusion device selected on the basis of the weight, which is a function of area of pay load bay of carrier aircraft.
The expression and role of NADPH Oxidase 2 in colon cancer
Authors: Takiguchi Koichi , Shimizu Hiroki , Shoda Katsutoshi , Shiraishi Kensuke , Furuya Shinji , Hosomura Naohiro , Akaike Hidenori , Kawaguchi Yoshihiko , Amemiya Hidetake , Kawaida Hiromichi , Mochizuki Kunio , Kondo Tetsuo , Ichikawa Daisuke
Published: January 2023

Background
Nicotinamide adenine dinucleotide phosphate (NADPH) Oxidases (NOXs) are transmembrane proteins that generate reactive oxygen species. Recent studies have reported that NOXs play important roles in the progression of various cancers. However, the expression and role of NOX2 in colon cancer is unclear. Therefore, this study aimed to investigate the expression of NOX2 and effects on the prognosis of patients with colon cancer, and also examined the pathophysiological role of NOX2 in cell proliferation and motility.
Methods
We used 116 primary colon cancer samples obtained from patients who underwent curative resection for stage II or III colon cancer for immunohistochemistry to assess the relationship between NOX2 expression and clinicopathological factors and evaluate the prognostic significance of NOX2 expression in colon cancer patients. The expression levels of NOX2 protein and mRNA in human colon cancer cell lines were analyzed and two highly NOX2 expressed cell lines (HCT116 and RKO) were used for further study. Knockdown experiments with NOX2 siRNA were performed, and the effects on cell proliferation, cell cycle progression, migration, and invasion were analyzed.
Results
Immunohistochemical staining revealed that NOX2 protein was scarcely expressed in noncancerous tissue compared to cancer tissue, and 45 samples (38.8%) had positive staining for NOX2 expression in cancer tissue. No clinicopathological factor was significantly associated with NOX2 expression. The 5-year recurrence-free survival rate of the NOX2 positive group was significantly lower than that of the NOX2 negative group (61.1% vs. 79.3%, p = 0.029). NOX2 depletion using siRNA significantly inhibited cell proliferation, G1 to S phase cell cycle progression, migration, and invasion in the two cell lines.
Conclusions
NOX2 expression affects the prognosis of colon cancer patients, as well as the tumorigenesis of colon cancer cells. NOX2 may be a novel biomarker and therapeutic target for colon cancer patients.
Expression of hornerin in skin lesions of atopic dermatitis and skin diseases
Authors: Makino Teruhiko , Mizawa Megumi , Takemoto Keita , Shimizu Tadamichi
Published: January 2023

Cornification is an essential process that confers the skin barrier function. Among the proteins associated with cornification, filaggrin (FLG) plays an important role, and mutations in the FLG gene were shown to be an important predisposing factor for atopic dermatitis (AD). We previously identified an FLG-like protein, hornerin (HRNR). The exact function remains unknown; however, it is hypothesized that HRNR is associated with cornification. Recently, there have been several reports regarding a relationship between HRNR and the pathogenesis of AD. In the present study, we examined the HRNR expression in the skin lesions of 7 unrelated AD patients to clarify the role of HRNR in the pathogenesis of AD. Three of 7 AD specimens were obtained from erythematous lesions, suggesting an acute phase; the others were obtained from lichenified or pruriginous eruptions, suggesting a chronic phase. HRNR was detected in chronic AD lesions, although no signals of HRNR were observed in acute AD lesions. HRNR was detected in the cytokeratin6-expressing area, while Ki67-positive keratinocytes were more abundant in HRNR-positive epidermis. These findings suggest that the expression of HRNR may be associated with the hyperproliferation of epidermis in chronic AD lesions. We next examined the HRNR expression in skin diseases associated with hyperkeratosis, including ichthyosis vulgaris, epidermolytic ichthyosis, Darier’s disease, lichen planus, pustulosis et plantaris, actinic keratosis, and seborrheic keratosis. The expression of HRNR was decreased in ichthyosis vulgaris and was increased in lichen planus and pustulosis et plantaris, in parallel with the expression of FLG. In contrast, HRNR signals were irregularly observed in different cells from those expressing FLG in epidermolytic ichthyosis or actinic keratosis. The abnormal epidermal differentiation in these diseases may affect the unique expression of HRNR. Accordingly, HRNR may play an overlapping role with FLG in cornification; however, this unique expression pattern of HRNR in some diseases supports that HRNR may have a distinct role in the molecular processes of cornification.
Anatomical characteristics and morphometric analyses of the internal carotid artery using retrospective angiographic images
Authors: Kirisattayakul Woranan , Kiatkitkul Nukanda , Trakulsantirat Montita , Munkong Waranon , Pattum Panuwat , Iwanaga Joe , Tubbs R. Shane , Chaiyamoon Arada , Iamsaard Sitthichai
Published: January 2023

Purpose
Anatomical variations of the internal carotid artery (ICA) can cause complications during endovascular treatments. Therefore, the aim of this study was to investigate the features of the ICAs obtained from 2D digital subtraction angiography (2D DSA).
Methods
The morphometrics and angles of the ICA segments from 2D DSA images from a total of 100 patients (45 males and 55 females) were investigated. The lengths (L1-3), angles (A1-3), and diameters (D1-6) through the ICA measurement points (5 segments: C2 [petrous], C3 [lacerum], C4 [cavernous], C5 [clinoid], C6 (ophthalmic] were systemically recorded by two observers. All measured parameters were compared for both sexes and sides.
Results
The lengths (mm) and angles of the ICA were 7.20 ± 2.22 (L1), 15.71 ± 2.32 (L2), 10.99 ± 1.66 (L3) and 109.31 ± 17.77 (A1), 107.87 ± 20.51 (A2), 80.81 ± 16.33 (A3), respectively. There were no differences in the angulations of the A1-A3 segments between the sexes (p > 0.05). The L2 (C3-C4) was significantly longer in males, but only the left side of females showed a greater length (p < 0.05). The averaged mean diameters of the ICA (D1-6) in both sexes were 4.17 ± 0.55 mm. However, the diameters of the D1–D6 from left and right sides of males except the right D6 were significantly longer than those of females (p < 0.05). Also of significance was that the right diameters of females (D1) and males (D1 and D2) were shorter compared to left sides.
Conclusion
This study demonstrates some differences in lengths, diameters, and angles in both sexes and sides of the normal ICA. Neurosurgeons and neurointerventionalists should be aware of such variations when operating, performing interventional procedures, and interpreting 2D DSA.
Packaging materials and storage conditions affect nutritional quality of blended guava nectar
Authors: Singh Ajit Kumar , Sagar Vidya Ram , Rudra Shalini Gaur , Kumar Raju
Published: January 2023

The present study was carried out to elucidate the influence of packaging materials and storage conditions on changes in nutritional quality of blended guava and coloured grapes nectar (50:50) during 4 month of storage. blended juice was packaged in amber colour as well as transparent glass bottle followed by stored at low (6 ± 1°C) and ambient temperature ((28 ± 2°C)). Total soluble solid (TSS), titratable acidity (TA), reducing sugar (RS) and total sugar (TS), total phenolic content (TPC), total anthocyanin (TAC), ascorbic acid (AA), antioxidant activity (AOX) and sensory evolution were recorded in freshly prepared blended juice and during the 4 month of storage. the result showed that the TSS, acidity reducing and total sugar increased whereas antioxidant, ascorbic acid, phenolic and total anthocyanin content decreased during the storage with respective of packaging material. Loss of ascorbic acid, phenolic and total anthocyanin content were higher in blended nectar which was stored at ambient temperature as compared to low temperature. The ratio of 50:50 of guava and coloured grape blends is most acceptable for the preparation of anthocyanin rich guava nectar with maximum retention of anthocyanins, flavor and other nutrient.
Cyclic Feeding Regime Stimulates Chromatin Condensation in the Hepatocytes Nuclei of Old Rats
Authors: Danladi Ceasar Dubor , Serakinci Nedime , Ivanovich Bozhkov Anatolii , Girich Mishel
Published: January 2023

Aging related Human malignancies and diseases are linked to flaws in chromatin condensation, which may be due to its significance in the segregation of chromosome, regulation of genes and apoptosis. Investigations of CR (Calorie Restriction) have given a significant information on the mechanisms that control cell reactions to metabolic variations and how these structures function in synergy towards ensuring a harmonized reaction, chromatin plays a vital part in this process. CFR (Cyclic feeding regime) is more beneficial than CR in that it is easy to carry out. Therefore the reason for this investigation was to investigate the effect of CFR on chromatin condensation in the hepatocytes nuclei of 20 months old rats. DNA accessibility assay was used as a marker for chromatin condensation using Acridine Orange,DNA accessibility is the ability of A.O to intercalate and stain the DNA structure .Thus from the DNA accessibility results DNA condensation increased to 66% with 34% DNA accessibility after the first fasting with a reduction to 41% with 59% DNA accessibility following refeeding. The second fasting-refeeding regime lead to a sharp 74% increase and 35% decrease in DNA condensation with 26% and 65% DNA accessibility respectively. They results showed that old animals responded to CFR, with they consecutive fasting regime increasing the chromatin condensation.
Antimicrobial resistance patterns of WHO priority pathogens isolated in hospitalized patients in Japan: A tertiary centre observational study
Authors: Nisa Tania Tabassum , Nakatani Daisaku , Kaneko Fumie , Takeda Toshihiro , Nakata Ken
Published: January 2023

Background
After issuing the "Global action plan on antimicrobial resistance" in 2015, the World Health Organization (WHO) established a priority pathogens list for supporting research and development of novel antimicrobials. We conducted a comprehensive analysis of the WHO priority organisms in a Japanese tertiary hospital to apprehend the local AMR epidemiology
Methods
Data were obtained from electrical medical records in Osaka University Hospital between January 2010 and March 2021. The critical, high, and medium "priority pathogens list" categories of the WHO were used to compare results between the early (2010–2015) and late (2016–2021) phases.
Results
Out of 52,130 culture-positive specimens, a total of 9,872 (18.9%) contained WHO priority isolates. In comparison to early phases, late phases were likely to have higher rates of carbapenem resistance in Pseudomonas aeruginosa (15.7% vs 25.0%, P < 0.001), 3rd generation cephalosporin resistance in Escherichia coli (11.5% vs 17.8%, P < 0.001) as well as Klebsiella pneumoniae (1.6% vs 4.4%, P < 0.001), and ampicillin resistance in Haemophilus influenzae (2.4% vs 3.9%, P < 0.001). After 2015, however, the proportion of methicillin-resistant and vancomycin-intermediate Staphylococcus aureus was low. In this study, in-hospital mortality was comparable among patients with resistance to the three WHO priority pathogen types: critical (5.9%), high (3.9%), and medium (3.8%), and no significant change was observed between two phases in each category. However, significant interactions for in-hospital mortality were observed in subgroup analyses between “critical priority” AMR and the presence of comorbid conditions, such as chronic kidney disease or diabetes mellitus.
Conclusions
To implement better antimicrobial stewardship policies and practices, local priority pathogens and "high-risk" patients for in-hospital death need to be acknowledged and evaluated periodically.
Azathioprine Hypersenitivity: a Sweet-like Syndrome
Authors: Sivanandam Lokesh Koumar , Razul Benazir Begum , Martinez Ernesto Calderon , Garikapati Sushmitha , Sanker Vivek , Siddiq Abdelmonem
Published: January 2023

Introduction: Azathioprine is a purine analog used to treat autoimmune diseases and steroid refractory chronic diseases. Azathioprine hypersensitivity can present occasionally within weeks of initial therapy as Sweet-like Syndrome.
Case Summary: A 35 year old woman with Systemic Lupus Erythematosus (SLE) presented to the emergency department with complaints of generalized maculopapular rash, facial swelling and bilateral lower extremity edema of 4 days duration and two day history of constitutional symptoms like fever and nausea within two weeks of beginning of Azathioprine therapy to treat existing Lupus Nephritis (⅔).
Reason for the Report: Extensive skin signs include Erythema nodosum, small vessel vasculitis, acute widespread exanthematous pustulosis, sweet syndrome, and nonspecific dermatosis can be seen in patients with azathioprine hypersensitivity syndrome. It is known that the drug's imidazole component interacts with particular proteins to produce haptens, which further trigger Type 3 hypersensitivity reactions.
Outcome: Our case demonstrates the very fast onset of Azathioprine-induced Sweet-like Syndrome that happens after taking the offending medication. After ruling out viral and autoimmune reasons, this diagnosis can be made using routine laboratory tests and the results of a skin biopsy. The use of corticosteroids coupled with the discontinuation of azathioprine led to the complete disappearance of symptoms.
Construction and Validation of the Predictive Model for Gallbladder Cancer Liver Metastasis Patients: A SEER-based Study
Authors: Zhang Woods , Chen Zhitian , Sa Benzhong
Published: January 2023

Background
The purpose of this present research was to construct a nomograph model to predict prognosis in gallbladder cancer liver metastasis (GCLM) patients so as to provide a basis for clinical decision-making.
Methods
We surveyed patients diagnosed with gallbladder cancer liver metastasis (GCLM) in the Surveillance Epidemiology and the End Results database (SEER) between 2010 and 2019. They were randomized 6:4 into a training set and a validation set. In the training set, statistically meaningful prognostic factors were determined using univariate and multivariate Cox regression analyses, and an individualized nomogram prediction model was generated. The prediction model was evaluated by C-index and calibration curves from the training set and the validation set.
Results
727 confirmed cases were enrolled in the research, 426 in the training set and 301 in the validation set. Factors including bone-metastasis, surgery, chemotherapy and radiotherapy were independent prognostic factors for cancer specific survival (CSS) rates and were employed in the construction of the nomogram prediction model. The C-index for the training set and validation set were 0.685 and 0.709, respectively. Calibration curves indicated that the cancer specific survival (CSS) rates of the nomograph prediction model were consistent with the actual prognosis at 6-months-CSS, 1-year-CSS and 2-years-CSS in both the training set and validation set.
Conclusions
We have successfully constructed a nomogram prediction model that can predict cancer specific survival (CSS) rates in patients with gallbladder cancer liver metastasis (GCLM). This prediction model can help patients in counseling and guide clinicians in treatment decisions.
Platelet closure time in the evaluation of efficacy of CAR-T cell therapy in relapsed/refractory multiple myeloma
Authors: Ma Ruixue , Liu Yang , Zhang Qi , Chen Huimin , Zhang Qianqian , Guo Wentong , Qiao Jianlin , Qi Kunming , Shen Guifang , Sun Cai , Song Xuguang , Cao Jiang , Cheng Hai , Zhu Feng , Yan Zhiling , Sang Wei , Li Depeng , Sun Haiying , Zheng Junnian , Li Zhenyu , Xu Kailin , Chen Wei
Published: January 2023

Purpose
In recent years, many studies of platelet function in multiple myeloma (MM) patients have been reported. However, the role of platelet function in relapse/refractory (R/R) MM after chimeric antigen receptor T (CAR-T) cell therapy remains to be clarified.
Methods
In this study, we investigated platelet closure time (PCT) in the evaluation of efficacy of CAR-T cell therapy in patients with R/R MM, clinical data of 50 patients were retrospectively analyzed. Collagen/adenosine diphosphate (CADP) and Collagen/Epinephrine (CEPI)-induced PCT of peripheral blood were detected by platelet function analyzer-200, respectively, with 20 healthy individuals as control.
Results
After the approach of CAR-T cell therapy, CADP PCT and CEPI PCT decreased significantly when compared with those before treatment: (67.22, 95% CI 46.91–87.53, P < 0.01) and (77.46, 95% CI 59.43–95.50, P < 0.01). CADP PCT was positively correlated with TT (r = 0.305, P = 0.047), ISS stage (r = 0.389, P = 0.005) and cytokine release syndrome (CRS) stage (r = 0.328, P = 0.020), whereas negatively associated with λ-type light chain (r = − 0.399, P = 0.014) and IgM (r = − 0.355, P = 0.017). In addition, patients who achieved >PR had a shorter PCT compared with those ≤ PR. Moreover, the PCT of patients with grade 3–5 CRS was considerably longer than grade 0–2 CRS after treatment.
Conclusion
PCT could be defined as a potential indicator in the evaluation of efficacy of CAR-T cell therapy.
Breakdown and absence of quasiparticles in Kitaev’s models
Authors:   , Smit Roman Louis
Published: January 2023

This thesis has two main parts. The first part is based on our publication [1], where we use perturbation theory to calculate decay rates of magnons in the Kitaev-Heisenberg-Γ (KHΓ) model. This model describes the magnetic properties of the material α-RuCl 3 , which is a candidate for a Kitaev spin liquid. Our motivation is to validate a previous calculation from Ref. [2]. In this thesis, we map out the classical phase diagram of the KHΓ model. We use the Holstein-Primakoff transformation and the 1/S expansion to describe the low temperature dynamics of the Kitaev-Heisenberg-Γ model in the experimentally relevant zigzag phase by spin waves. By parametrizing the spin waves in terms of hermitian fields, we find a special parameter region within the KHΓ model where the analytical expressions simplify. This enables us to construct the Bogoliubov transformation analytically. For a representative point in the special parameter region, we use these results to numerically calculate the magnon damping, which is to leading order caused by the decay of single magnons into two. We also calculate the dynamical structure factor of the magnons. The second part of this thesis is based on our publication [3], where we use the functional renormalization group to analyze a discontinuous quantum phase transition towards a non-Fermi liquid phase in the Sachdev-Ye-Kitaev (SYK) model. In this thesis, we perform a disorder average over the random interactions in the SYK model. We argue that in the thermodynamic limit, the average renormalization group (RG) flow of the SYK model is identical to the RG flow of an effective disorder averaged model. Using the functional RG, we find a fixed point describing the discontinuous phase transition to the non-Fermi liquid phase at zero temperature. Surprisingly, we find a finite anomalous dimension of the fermions, which indicates critical fluctuations and is unusual for a discontinuous transition. We also determine the RG flow at zero temperature, and relate it to the phase diagram known from the literature.
Fallzahlaufkommen und Qualitätsindikatoren bei der Versorgung des abdominellen Bauchaortenaneurysmas
Authors:   , Ahmadzadeh Yasmin Carmen
Published: January 2023

Hintergrund: Der MTL30 ist ein Surrogatparameter, der bisher in visceralchirurgischen Registern verwendet wird, um eine Prognose über die Qualität verschiedener komplikationsträchtiger Eingriffe abzugeben. Der Marker wird als positiv gewertet, wenn ein Patient am 30. postoperativen Tag verstorben (mortality) ist, in ein anderes Akutkrankenhaus verlegt (transfer) werden musste oder weiterhin im Krankenhaus verweilen muss (length of stay >30 days). Zielsetzung: In dieser Arbeit sollte untersucht werden, ob der MTL30 eine Aussage über die Qualität der operativen Versorgung des Bauchaortenaneurysmas (AAA) abgeben kann. Dazu sollten Kliniken mit unterschiedlichem Fallaufkommen hinsichtlich Letalität und MTL30 miteinander verglichen werden. Zusätzlich sollten Literaturempfehlungen zu Mindestmengen des Fallaufkommens überprüft werden. Methodik: Insgesamt wurden 18.205 elektive Eingriffe aus dem AAA- Register des Deutschen Instituts für Gefäßmedizinische Gesundheitsforschung (DIGG) der Deutschen Gesellschaft für Gefäßchirurgie und Gefäßmedizin (DGG) analysiert. 14.282 Patienten wurden mittels endovaskulärer Aortenaneurysmaversorgung (EVAR) und 3.923 Patienten mittels offener Versorgung (OAR) behandelt. Die Ergebnisse wurden zum Fallaufkommen der Kliniken in Beziehung gesetzt. Ergebnisse: Weder für die Letalität noch für den MTL30-Wert konnten Volumen- Ergebnisbeziehungen gefunden werden. Bei EVAR lag die Sterblichkeit im Quintil 1 des Fallaufkommens bei 1,0% und im Quintil 5 bei 1,3%. Auch beim MTL30 ergaben sich keine signifikanten Unterschiede zwischen Quintil 1 und 5, der MTL30 belief sich jeweils auf 5,3%. Bei OAR war die Klinikletalität in dem Quintil mit dem geringsten Fallaufkommen (Quintil 1) mit 5,8% verglichen mit Quintil 5 (höchstes Fallaufkommen, Klinikletalität 3,5%) im Trend höher, aber nicht signifikant unterschiedlich (p= 0,505). Auch bei OAR korrelierte der MTL30 nicht mit dem Fallaufkommen (Quintil 1: 16,4% vs. Quintil 5:12,2%, p=0,110). Jedoch korrelierte die Liegedauer bei EVAR und OAR sowohl mit der Letalität (EVAR: Quintil 1 der Liegezeit 1,69% vs. Quintil 5 1,02%, p= 0,042; OAR: Quintil 1: 6,78% vs. Quintil 5: 2,16%, p= 0,000) als auch mit dem MTL30 (EVAR: Quintil 1 der Liegezeit 7,35% vs. Quintil 5 2,85%, p=0,000; OAR: Quintil 1 26,28% vs. Quintil 5 5,19%, p= 0,000). Folgerung: Es konnte weder bei EVAR noch bei OAR ein Zusammenhang zwischen dem jährlichen Fallaufkommen und der Letalität bzw. dem MTL30 gefunden werden. Ob der MTL30 gegenüber der alleinigen Erfassung der Klinikletalität als Qualitätsparameter einen Zusatznutzen bietet, muss offenbleiben. Ein vielversprechenderer Marker scheint die stationäre Liegedauer zu sein, die zusätzlich zur Letalität als Qualitätsparameter verwendet werden könnte.
information system for data collection for community-based rehabilitation programs
Authors: Darmawan Wawan , Nur Firdaus
Published: January 2023

Program Rehabilitasi Bersumberdaya Masyarakat adalah program pembinaan wilayah dalam hal pencegahan kedisabilitasan/kecacatan, deteksi dan rehabilitasi/habilitasi segala aspek kehidupan untuk pemberdayaan Penyandang Disabilitas, keluarga dan masyarakat. Pada tugas skripsi ini penulis mengangkat masalah, bagaimana membuat sistem informasi pendataan dan dapat di implementasikan pada organisasi Pusat Studi dan Informasi Kedisabilitasan Indonesia.

Untuk mendukung perancangan system informasi ini penulis mengumpulkan informasi melalui observasi, studi kepustakaan, dan dokumentasi. Program ini dibuat dengan Bahasa pemograman PHP dan MySql sebagai basis data. Sistem ini menggunakan metode Sosfware Development Life Cycle (SDLC) dengan menggunakan salah satu modelnya yaitu model Waterfall dengan tahapan dalam perancangan ini meliputi analisis kebutuhan perangkat lunak dan perangkat keras, perancangan sistem, pengkodean, pengujian, dan pemeliharaan program yang dibuat.

Sistem Informasi yang dirancang ini dapat membantu organisasi Pusat Studi dan Informasi Kecacatan Indonesia dalam mengelola database, sehingga memudahkan dalam proses evaluasi dan monitoring program Rehabiliasi Bersumberdaya Masyarakat.

Kata kunci : Pemberdayaan, Disabilitas
IMPLEMENTASI PIVOT TABLE UNTUK PENILAIAN BERBASIS CPMK
Authors: Wijana Katon , Oslan Yetli , Kristanto Harianto
Published: January 2023

Akreditasi merupakan kegiatan penilaian sesuai dengan kriteria yang telah ditetapkan berdasarkan Standar Nasional Pendidikan Tinggi (SNDikti). Akreditasi dilakukan untuk menentukan kelayakan Program Studi dan Perguruan Tinggi atas dasar kriteria yang mengacu pada SNDikti, sebagaimana diamanatkan oleh Undang-undang Nomor 12 Tahun 2012 tentang Pendidikan Tinggi Pasal 55 Ayat (1) dan Ayat (2). Standar kompetensi lulusan merupakan kriteria minimal tentang kualifikasi kemampuan lulusan yang mencakup sikap, pengetahuan, dan keterampilan yang dinyatakan dalam rumusan capaian pembelajaran lulusan(CPL). Capaian pembelajaran lulusan (CPL) masih bersifat umum, harus dijabarkan ke dalam bentuk yang lebih spesifik yaitu ketercapaian capaian pembelajaran mata kuliah (CPMK), setiap mata kuliah wajib mempunyai CPMK yang mengacu pada CPL.

Dalam pemberian nilai pada CPMK, banyaknya nilai yang dimasukkan untuk tiap mata kuliah berbeda-beda, oleh karenanya nilai-nilai CPMK tiap mata kuliah akan disimpan dalam bentuk baris-baris rekaman nilai. Untuk merangkum nilai-nilai CPMK dalam bentuk baris ini dapat dibuat pivot table dalam bentuk kolom-kolom, namun dalam sebuah universitas, tiap program studi mempunyai ragam dan jumlah CPMK yang berbeda-beda, oleh karenanya tidak bisa dibuat suatu pivot table yang spesifik untuk ragam dan jumlah CPMK tertentu, sehingga harus dibuat suatu pivot table yang bersifat fleksibel baik ragam maupun jumlahnya.

Pada penelitian ini akan dibuat suatu program aplikasi yang dapat dipergunakan untuk mengukur ketercapaian pembelajaran lulusan (CPL) berbasis capaian pembelajaran matakuliah CPMK memakai pivot table generator sehingga dapat bersifat fleksibel baik dari sisi ragam CPL maupun banyaknya CPL program studi.

Kata Kunci— Pivot table, generator,  capaian pembelajaran lulusan
Penerapan Simhash dan Hamming distance dalam Deteksi kemiripan Teks Berita
Authors: Anggelina Mayesti , Dwi Krisnawati Lucia Dwi Krisnawati , Sebastian Danny
Published: January 2023

Daur Ulang Text didefinisikan sebagai pemanfaatan sumber tulisan yang ada untuk penulisan sebuah teks baru. Persentase penggunaan ulang teks dari sumber sebelumnya sangatlah bervariasi.  Jika prosentase penggunaan tersebut tinggi dan berasal dari sebuah sumber, maka teks yang baru menjadi teks duplikat atau hampir duplikat dengan teks sumbernya. Meskipun beberapa genre teks bisa diterima, keberadaan teks duplikat dan hampir dupilkat ini menyebabkan ketidak-efisienan penyimpanan dan pencarian. Untuk itu diperlukan sebuah system deteksi kemiripan teks yang akan mengidentifikasi teks mana saja yang dupilkat dan hampir duplikat. Untuk itu, penelitian ini berfokus pada deteksi kemiripan teks dengan mengaplikasikan algoritma Simhash. Algoritma ini digunakan untuk menghasilkan fingerprint dokumen yang berfungsi sebagai fitur dokumen yang digunakan sebagai dasar pembanding tingkat kemiripan teks. Kemiripan sebuah teks terhadap teks lainnya diukur dengan menggunakan jarak Hamming. Dalam ekperimen yang difokuskan pada dokumen duplikat dan hampir duplikat, tingkat Recall dokumen cukup tinggi yakni 80%. Ini berarti bahwa sistem yang dikembangkan mampu menemenukan pasangan dokumen duplikat dengan baik.
Assessment of Macroplastic Litter on the Coastal Seabeds of Sultan Naga Dimaporo, Lanao Del Norte, Philippines
Authors: Pacilan Christine Joy , Bacosa Hernando
Published: January 2023

Plastic pollution is an arising problem of our generation. Tons of plastics are globally produced affecting different coastal ecosystems. Plastics pile and end up in coastal areas, at the ocean surface, and in the coastal seabed. Almost 70% of plastics made are known to eventually sink in water, and it is suspected that ever-increasing amounts of plastics are accumulating in seabed sediments. However, there are limited studies on macroplastics in coastal seabeds in the different coastal ecosystems in the Philippines. This study aims to determine the prevalence, types, and density of macroplastic litters in the coastal seabed of Sultan Naga Dimaporo (SND), Lanao del Norte. A 100-m transect line with four quadrats measuring 5 m x 5 m, was delineated parallel to the seabed at the beaches of Barangay Pikalawag, Dabliston, Koreo and Sugod. Results revealed that all four sites were contaminated with plastic litter in which 55% were from Pikalawag, a residential area, 16% from Dabliston, a mangrove area, 15% from Sugod, a beach/tourism area, and 14% from Koreo, a non-residential area. The plastic density was 1.32 items/m2 for Pikalawag, and 0.32 to 0.37 items/m2 for the other areas. The waste collected was primarily food packaging (17%), plastic fragments (16%), and plastic bags (11%). The highest polymer type was LDPE (40%) followed by both multilayers (13%) and PET (13%). Based on the clean coast-index, Pikalawag can be categorized as extremely dirty while the other three sites were moderately clean. Overall, this study showed how the prevalence and composition of plastic litter vary in different coastal seabeds in SND, Lanao del Norte.
St Ives Island: The persistent mischaracterisation of a Cornish headland
Authors: Hayward Philip
Published: January 2023

There are various locations designated as islands in popular and/or official usage that do not conform to the established definition of their being areas of land surrounded by water. After a discussion of the six types of mischaracterised islands in England, this short article provides a case study of one such location, St Ives Island, in the county of Cornwall. Discussion extends to possible historical causes of the area’s island designation and how this designation has been perpetuated in common usage, place naming and in tourism and product promotion. The case study highlights that the affective aspect of perceived islandness is more important in local contexts than fidelity to strict geographic definitions.
A Study on the Effects of Immersive Content Use on Positive affect, Self-esteem, and Psychological Happiness of Disabled Persons: To advocate the dissemination of immersive content facilities in island areas
Authors: Lee Sae-Hoon , Kang Hyun-Chul , Kim Jong-Sung , Lee Chang-Keun
Published: January 2023

The purpose of this study is to analyze the structural relationships among immersive content use satisfaction, positive affect, self-esteem, and psychological happiness of persons with disabilities and thereby investigate the positive effect of immersive content experience on disabled persons who wish to have immersive content facilities for disabled persons in island areas. Using survey data collected from physically and mentally disabled persons using immersive content facilities, the study found that disabled persons’ satisfaction with immersive content was significantly and positively associated with their positive affect, self-esteem, and psychological happiness; positive affect and self-esteem of disabled persons using immersive content were significantly and positively associated with their psychological happiness; positive affect and self-esteem significantly mediated the relationship between use satisfaction of disabled persons using immersive content and their psychological happiness. This study is meaningful in that it is the first study that empirically investigated the effect of immersive content facilities on disabled persons and shed light on the potential role of immersive content in improving the quality of life and happiness of disabled persons by enabling them to virtually experience real-world programs.
Disapproving the Null Hypothesis in Molecular Genetics
Authors: Datta Neelabh
Published: January 2023

The null hypothesis is a statement that asserts that there is no relationship between two variables or no difference between two groups. In molecular genetics, the null hypothesis is often used to test the validity of research hypotheses that pertain to the relationship between specific genetic variations and various traits or diseases. In this article, I will discuss the process of disapproving the null hypothesis in the context of molecular genetics research and the importance of accurately doing so in order to draw valid conclusions from studies.
Effect of Different Al2O3 Supports on the Synthesis of Tetralin by Selective Catalytic Hydrogenation of Naphthalene
Authors: Su Xiao-Ping , Zhao Le , Wang Xiang-Tong , Wang Zhao , Wang Zhi-Chao , Shen Tao , Zhang Ping
Published: January 2023

Different Al2O3 carriers were synthesized by co-precipitation and sol-gel method. From them, 4%NiO-20%MoO3/Al2O3 catalysts were prepared by incipient wetness impregnation. The catalysts were characterized by X-ray diffraction analysis (XRD), N2 adsorption-desorption, NH3-temperature programmed desorption (TPD) and H2-temperature programmed reduction (TPR) and subsequently used for selective hydrogenation of naphthalene to high-value tetralin. The results showed that Ni-Mo/so-ge Al2O3 (900) exhibited better catalytic performance than Ni-Mo/commercial Al2O3, achieving 99.56% naphthalene conversion and 99.43% tetralin selectivity.
Ithbāt Ṭalāq: An Offer of Legal Solutions to Illegal Divorce in Indonesia
Authors: Wahyudi Firman
Published: January 2023

The dispute between Islamic law and positive law is continuously ongoing regarding the practice of illegal divorce. This practice is valid in Islamic law as long as the conditions and pillars are fulfilled. However, in Islamic law, it is considered a violation of marriage norms. The urgency of this study lies in the discourse of ithbāt ṭalāq to bridge the rise of illegal divorce in society. Through a literature review with a juridical approach to finding a legal basis for a case in concreto, this article shows that ithbāt ṭalāq functions as an instrument that can solve disputes between Islamic law and positive law. Through this instrument, husbands who force divorce out of court can be considered criminal actors who must be given sanctions in the form of ta'zīr (fine).
Dawn of Justice: Evaluating the Alignment of Women and Children in Aceh's Qanun Jinayat
Authors: Muzakkir Muzakkir
Published: January 2023

Aceh Qanun No. 6 of 2014 concerning the Jinayat Law can potentially eliminate justice for women and children. Through a literature study using a descriptive-analytical method, this article aims to interpret the substance of the Qanun Jinayat. The results show that the Qanun Jinayat has not taken sides with women and children. The first evidence, the preliminary evidence requirement for rape victims in the Qanun Jinayat, provides an opportunity to harm women. Victims may be unable to show evidence due to their psychological pressure. The second piece of evidence, the existence of legal dualism, between Article 81 and Article 82 of the Child Protection Law and Article 47 of the Qanun Jinayat, provides opportunities for violence to children. Qanun Jinayat provides lighter sentences to perpetrators. This article finds that the Qanun Jinayat was formulated and ratified with minimal involvement of many parties and absorption of community aspirations. The article recommends that the formulation of the Qanun Jinayat should be revised with consideration of the public benefit by involving modernist academics with a comprehensive religious education background.
Headwater Stream’s Fish Assemblages: What Diversity and Environment Tell us about their Structure and Organization?
Authors: Carvalho Rodrigo Assis de , Tejerina-Garro Francisco Leonardo
Published: January 2023

Understanding the relationship among descriptors of community diversity and the response of these descriptors to the environment is a cornerstone to ecological studies. In this study, we used a set of headwater stream’s fish assemblages to answer two questions: 1) How do distinct descriptors of fish assemblage’s diversity are related to each other at headwater streams?; 2) How does environment influences each descriptor of fish assemblage’s diversity at headwater streams? As metrics of community structure/diversity, we used the number of species (species richness, S) and individuals (abundance, N), taxonomic distinctiveness (taxonomic diversity, Δ+), and the mean pairwise distance (functional diversity, MPD). The environmental variables evaluated were the following: channel depth and channel width, altitude, riparian vegetation cover, water turbidity and water temperature, dissolved oxygen, pH, and conductivity. The relationship among descriptors of fish assemblage’s diversity and between these descriptors with the environment was tested with a Spearman’s correlation analysis. We found a positive correlation between: i) Δ+ and MPD; and ii) N and Δ+ with channel width and temperature, respectively. These findings provide evidence that different descriptors of fish assemblage’s diversity are influenced by different variables of the environment at headwater streams. Moreover, we observed the existence of a spatial congruence between Δ+ e MPD, suggesting that the development of strategies for protecting one of these descriptors may also help to preserve the other one. Our study provides important information for a region of the Central Brazil, the Upper Paraná River basin, that remains not well known regarding to its fish fauna when compared to other localities in this same region or within its hydrological domain.
Variability of Volatile Oils Composition, Tannins, and Phenols from Campomanesia adamantium (CAMBESS.) O. Berg
Authors: Sá Stone de , Fiuza Tatiana de Sousa , Borges Leonardo Luiz , Cunha Luiz Carlos da , Oliveira Neto Jerônimo Raimundo de , Paula José Realino de
Published: January 2023

Campomanesia adamantium (Myrtaceae), known as "guabiroba-do-campo", is a native Cerrado shrub popularly used as anti-inflammatory, antidiarrheal, urinary tract antiseptics. The aims of this study were evaluate the seasonal variability of total phenols and tannins and chemical compounds of the volatile oils of C. adamantium leaves in a period of 12 months. The leaves and flowers were collected in Bela Vista, Goiás, Brazil. The volatile oils were obtained by hydrodistillation in a Clevenger apparatus and analyzed by GC/MS. The determination of total phenols and tannins was performed by the method of Hagerman and Butler. The major compounds of the leaves oils were γ-elemene, limonene, italicene epoxide, β-funebrene, bicyclogermacrene, linalool, and those of flower oil were sabinene, limonene, linalool, tricyclene and methyl salicylate. The total phenols content ranged from 3.75% to 9.56% and tannins content from 2.25% to 4.84%.  It was concluded that the best period for collecting the leaves with the highest index phenols and tannins is the low rainfall. This work represents the first description of the seasonal variability of the essential oils, tannins and total phenols of C. adamantium collected in Bela Vista.
Neuroeducación e Inclusividad en el Marco de la Comunicación y el Turismo
Authors: Barrientos-Báez Almudena , Caldevilla-Domínguez David , Parra-López Eduardo
Published: January 2023

El Libro Blanco del Diseño para Todos en la Universidad (2006), marcó un antes y un después para favorecer cambios sustanciales en los planes de estudio de las diferentes universidades españolas. Las instituciones públicas apoyan explícitamente la corriente de pensamiento de la inclusividad y el respeto hacia todos desarrollando un trabajo que ayuda a los estudiantes y profesores a colaborar en el proyecto de Capacitación universitaria en el diseño para todas las personas. Se basa en la colaboración entre diferentes administraciones públicas con empresas del sector privado.

Los graduados en Turismo durante el ejercicio de su profesión interactúan con personas que pueden tener dificultades de movilidad o patologías que pueden dificultarles disfrutar del destino turístico. Por lo tanto, la educación y la comunicación se convierten en el núcleo de esta investigación. A partir de la aplicación de una metodología de análisis bibliográfico y documentos oficiales, se analiza la situación actual con el objetivo de fomentar la enseñanza con estilos de aprendizaje activos que motivan al alumno a capacitarse para aumentar y facilitar la inclusión y el disfrute de todos en el sector turístico, tanto por viajeros como por los propios trabajadores. En este sentido, herramientas innovadoras tales como la neuroeducación deben ser consideradas como instrumentos válidos.
Sustentabilidade Apícola em Ambiente Semiárido do Brasil: Determinação de Pontos Críticos
Authors: Felipe Neto Carlos Antonio Lira , Amaral Xaila Sant Anna , Sousa Francisco de Assis Salviano de
Published: January 2023

Na conjectura global, a atividade apícola tem vivenciado uma série de ameaças provocada, principalmente, pela modernização da agricultura. No Brasil, o segmento apícola tem enfrentado ainda carências de planejamento, de organização, de gerenciamento técnico e de suporte público. Tais condições podem arriscar a sustentabilidade da apicultura, especialmente quando submetida a estresses climáticos intensos, característicos de regiões semiáridas. A compreensão científica desse cenário tem sido urgentemente requisitada para garantir o futuro da apicultura. Por esta razão, pretende-se com este estudo identificar pontos críticos acerca da sustentabilidade de sistemas de produção apícolas localizados em ambiente semiárido do Brasil. O Marco para a Avaliação de Sistemas de Manejo de Recursos Naturais Incorporando Indicadores de Sustentabilidade (Mesmis) foi aplicado em 19 unidades de análise, fazendo-se uso da literatura especializada, de visitas de campo e de entrevistas semiestruturadas. O confrontamento de dados (primários e secundários) pela equipe da pesquisa permitiu o apontamento de nove pontos críticos (assistência pública, associativismo, autonomia, capacitação, manejo, qualidade da paisagem, qualidade de vida, produtividade apícola e variabilidade climática). Essa conjuntura evidenciou questões ambientais, sociais e econômicas da atividade apícola atual, que precisam ser consideradas pelos atores sociais envolvidos. Logo, a (in)sustentabilidade de sistemas apícolas no Semiárido brasileiro pode ser determinada pelo nível de comprometimento com a correção de fragilidades e com o aprimoramento de potencialidades apícolas.