bluuebunny/crossref_metadata_2025 huggingface dataset:
Deflating Miconia (Melastomataceae) from Eastern Brazil, with 31 new synonyms and other nomenclatural issues

Authors: CADDAH MAYARA K. , AUGUSTIN ANA FLÁVIA , GOLDENBERG RENATO
Published: October 2020

We propose 31 synonyms for nine South American species of Miconia (Melastomataceae), mostly from the Atlantic Forest in Brazil (with one species in “campos rupestres” and another from the Atlantic Forest in Paraguay); all belong to the ‘Miconia discolor clade’. Of these synonyms, 19 are species and 12 are varieties or subspecies, all of them described by the end of the XIX or early XX centuries, and most of them known in herbaria mostly from isotypes or syntypes (except for Miconia cabucu, M. chartacea and M. saldanhae). Miconia flammea var. major is synonymized under M. brunnea; Miconia amambayensis and M. oblongifolia under M. buddlejoides; Miconia augusti, M. divaricata, M. fasciculata subsp. catharinensis, M. fasciculata var. robusta, M. fluminensis, M. gilva, M. rabenii, M. saldanhae, M. saldanhae var. grandifolia and M. saldanhae var. subsessilifolia under M. fasciculata; Miconia chartacea, M. chartacea var. angustifolia, M. chartacea var. brevifolia, M. chartacea var. longifolia and M. chartacea var. miqueliana sob M. flammea; Miconia altissima, M. cabucu, M. formosa var. angustifolia, M. gigantea, M. mourae, and M. ovalifolia under M. formosa; Miconia ovata under M. organensis; Miconia maximowicziana and M. maximowicziana var. major under M. sclerophylla; Miconia eichleri, M. eichleri var. australis, and M. pseudoeichleri under M. valtheri; and Miconia argyraea under M. willdenowii. We also designate lectotypes for all names but M. fasciculata subsp. catharinensis, M. maximowicziana and M. ovata, which already have holotypes designated by the respective authors. We corrected the spelling of M. buddlejoides (previously known as M. budlejoides), M. saldanhae (formerly M. saldanhaei) and M. mourae (formerly M. mouraei). In the present century, 14 species of Miconia s.s. have been described for the Atlantic Forest, and another 43 species, subspecies and varieties have been synonymized (including the ones performed here). This means that a significant inflation of names has been corrected, since the genus has been deflated by 29 taxa. The synonyms proposed here will help students of the family and other researchers employ the correct names in biological studies, which in turn will help to fine tune biodiversity studies and conservation efforts.
Three new species of the genus Bodotria (Crustacea: Cumacea: Bodotriidae) from the Yellow Sea in Korea
Authors: KIM SUNG-HYUN , LEE CHANG-MOK , KIM YOUNG-HYO
Published: October 2020

Three new species of Cumacea belonging to the genus Bodotria were collected from the Yellow Sea in Korea. Among them, Bodotria (Bodotria) hwanghaensis sp. nov. and Bodotria (Bodotria) pseudomaculosa sp. nov. share the dorso-lateral carina on the carapace and uniarticulated uropod endopod with other Korean Bodotria species. In contrast, the last one, Bodotria (Atlantobodotria) incarinata sp. nov. lacks the dorso-lateral carina on the carapace and has a biarticulated uropod endopod. The new species B. (A.) incarinata sp. nov. can be distinguished from all other Bodotria species by the combination of carapace without dorso-lateral carina or ridge, dorso-median carina marked over whole length of carapace, antero-lateral corner of carapace rounded, antennal notch shallow, maxilliped 3 merus and carpus dilated, pereopod 1 carpus not dilated, and pereopod 2 basis with plumose seta. The new species B. (B.) hwanghaensis sp. nov. can be distinguished from all other Bodotria species by the combination of carapace almost ovoid in dorsal view, carapace lower edge of mid-lateral depression forming a faint ridge, pereopod 1 carpus not dilated, and pereopod 2 basis without plumose seta. The new species B. (B.) pseudomaculosa sp. nov. can be distinguished from all other Bodotria species by the combination of carapace surface covered with coarse squamosa-reticulate patterning formed by large, shallow pits, carapace lower edge of mid-lateral depression forming an angular ridge, pereopod 1 carpus little dilated, and pereopod 2 basis with plumose seta. We described with full illustrations, including mouthparts for the three new species. Also, a key to the Korean Bodotria species is provided.
Replacement name for Cleta Mulsant, 1850 (Coleoptera: Coccinellidae: Epilachnini)
Authors: SZAWARYN KAROL , TOMASZEWSKA WIOLETTA
Published: October 2020

Recently the classification of the ladybird beetles’ tribe Epilachnini was revised based on morphological and molecular data (Szawaryn et al. 2015, Tomaszewska & Szawaryn 2016). Based on these findings a new classification of the tribe was proposed. The genus Epilachna Chevrolat in Dejean, 1837 sensu lato was split into several clades, with Epilachna sensu stricto limited to New World fauna, and one of the Afrotropical clades, formerly defined as Epilachna sahlbergi-group (Fürsch 1963), has been named Chazeauiana Tomaszewska & Szawaryn, 2015 (Szawaryn et al. 2015), with Epilachna sahlbergi Mulsant, 1850 as the type species. However, that taxon received an unnecessary replacement name, as Mulsant (1850) already described a subgenus of Epilachna named Cleta distributed in Afrotropics, with Epilachna eckloni Mulsant, 1850 as the type species, which also belongs to the E. sahlbergi-group. Consequently Cleta has been elevated to the genus level (Tomaszewska & Szawaryn 2016) and Chazeuiana was synonymized with Cleta as a junior synonym. Nonetheless, authors (Tomaszewska & Szawaryn 2016) were not aware that the name Cleta is preoccupied. It appeared that Duponchel (1845) established the genus Cleta in the family Geometridae (Lepidoptera) that makes Cleta Mulsant (1850) a junior homonym. Therefore, we propose here Afrocleta nom. nov. as a replacement name for Cleta Mulsant, 1850.
Improving Ensemble Weather Prediction System Initialization: Disentangling the Contributions from Model Systematic Errors and Initial Perturbation Size
Authors: Hamill Thomas M. , Scheuerer Michael
Published: October 2020

Characteristics of the European Centre for Medium-Range Weather Forecast’s (ECMWF’s) 0000 UTC diagnosed 2-m temperatures (T2m) from 4D-Var and global ensemble forecasts initial conditions were examined in 2018 over the contiguous United States at 1/2° grid spacing. These were compared against independently generated, upscaled high-resolution T2m analyses that were created with a somewhat novel data assimilation methodology, an extension of classical optimal interpolation (OI) to surface data analysis. The analysis used a high-resolution, spatially detailed climatological background and was statistically unbiased. Differences of the ECMWF 4D-Var T2m initial states from the upscaled OI reference were decomposed into a systematic component and a residual component. The systematic component was determined by applying a temporal smoothing to the time series of differences between the ECMWF T2m analyses and the OI analyses. Systematic errors at 0000 UTC were commonly 1 K or more and larger in the mountainous western United States, with the ECMWF analyses cooler than the reference. The residual error is regarded as random in character and should be statistically consistent with the spread of the ensemble of initial conditions after inclusion of OI analysis uncertainty. This analysis uncertainty was large in the western United States, complicating interpretation. There were some areas suggestive of an overspread initial ensemble, with others underspread. Assimilation of more observations in the reference OI analysis would reduce analysis uncertainty, facilitating more conclusive determination of initial-condition ensemble spread characteristics.
Modifying the Extended Forecast Graphic to Improve Comprehension
Authors: Reed Jacob R. , Senkbeil Jason C.
Published: October 2020

The extended forecast graphic (EFG) is a popular graphic used by meteorologists to convey weather information, but it is poorly understood by the public. Deficiencies in the format, content, and presentation of the EFG contribute to a decrease in the efficacy of this graphic and reduce the comprehension of weather information. The format of the EFG has largely gone unchanged since the graphic first became popular more than four decades ago. The goal of this research was to modify the format of the existing EFG to address current limitations that inhibit understanding and create confusion among the public. Data were gathered from an online survey of the public (n = 885). Four modified versions of the EFG were developed, evaluated, and compared with the existing EFG. Removing probability of precipitation (PoP) information, reducing the number of days shown, and switching to a horizontal layout featuring timing and intensity information resulted in higher percentages for comprehension of weather information and positive comments when compared with the current version. A majority of participants responded that forecasters could accurately predict the weather 3 days out, providing justification for the reduction in number of days shown in the modified EFGs. Results suggest that agencies and members of the meteorological community should continue evaluating and discussing the most effective ways to use graphics to convey weather information to their audiences.
Perceived Immigrant Threat and Punitive Attitudes: The Moderating Effect of Economic Insecurity
Authors: Trahan Adam , Pierce Kelly
Published: October 2020

One of the strongest predictors of punitive attitudes is out-group prejudice. Two limitations of this literature are a relative lack of research examining (a) these relationships outside the United States and (b) the theoretical mechanisms involved. The current study tests the direct and moderating effects of group threat and economic insecurity on punitive attitudes among German citizens. Findings show the direct effect of group threat on punitive attitudes was significant and positive in three OLS regression models measuring different perceptions of threat by immigrants. The direct effect of economic insecurity on punitive attitudes was non-significant, but economic insecurity had a significant moderating effect on out-group prejudice and punitiveness in all three models.
Effect of infiltrated eutectic AlSi on the microstructure and properties of C/C composites
Authors: Liu Lei , Li Boyan , Guo Yongchun , Yao Xiyuan , Yang Wei , Feng Wei , Chen Xingyu , Wei Xiaotian , Gao Yu
Published: October 2020

Eutectic AlSi alloy was pressure infiltrated into a porous C/C skeleton to develop a low cost new C/C composite for application without extreme high temperature. C/C composite possessed a density of 1.7 g/cm3 was prepared for comparison. The effects of filling AlSi with and without Al-Ti-C grain refiner on the microstructure and properties of C/C composites were mainly studied. Result indicated that the introduced AlSi interpenetrated with C/C skeleton and made the composites compact. In comparison with C/C composite, the compressive strength and particle erosion resistance were greatly enhanced while the density and thermal expansion coefficient (CTE) increased slightly. After adding the refiner, Si network involved dendritic Al in C/C-AlSi was transformed to refined mixed AlSi, Al bulk and Si surrounded dendritic Al, and two kinds of micro-cracks came into being, which resulted in the decreased strength, improved erosion property and increased CTE of C/C-AlSiR. Both AlSi textures and micro-cracks in the modified C/C composites determined the crack propagation and led to their different compressive behaviors and anti-erosion abilities.
At War and at Home: The Consequences of US Women Combat Casualties
Authors: Cohen Dara Kay , Huff Connor , Schub Robert
Published: October 2020

What are the consequences of women dying in combat? We study how women fighting on the frontlines of the military affects public attitudes toward (1) military conflict and (2) women’s equality. We demonstrate through a series of survey experiments that women dying in combat does not reduce public support for war. However, women’s combat deaths do shape perceptions of women’s equality. Women dying in combat increases support for gender equality, particularly in the public sphere of work and politics, but only among women respondents. The findings indicate that women’s combat deaths do not undermine leaders’ ability to garner support for war, but combat service—and indeed, combat sacrifice—alone is insufficient to yield women’s “first-class citizenship” among the general US public. The results highlight how major policy changes challenging traditional conceptions of gender and war can generate positive attitudinal shifts concentrated among members of the underrepresented community.
The Gravity of Transnational Terrorism
Authors: Carter David B. , Ying Luwei
Published: October 2020

Transnational terrorism is an inherently international phenomenon as it involves attacks where the perpetrators are from a different country than the victims. Accordingly, a growing literature explains patterns in transnational attacks with a focus on international variables, for example, the presence of a border wall or alliance patterns. Despite the importance of the topic, no common empirical framework with theoretical basis has emerged to analyze the flows of transnational attacks. We propose that recent versions of the structural gravity model of transnational flows, long the workhorse model in trade economics, can be modified to provide a theoretically motivated model of the flows of transnational terrorist attacks among countries. The gravity model provides several empirical advantages for the study of international variables and transnational terrorism, for example, recent specifications allow the researcher to estimate count models that condition out all time-varying country-level confounders with fixed effects. This facilitates sidestepping the typical problem that any international variables associated with transnational flows are often correlated with omitted or imprecisely measured domestic factors, which draws their estimates into question. Moreover, we demonstrate that the structural gravity model does a much better job in predicting outcomes, particularly when multiple attacks flow across borders.
A Qualitative Study of Organizational and Psychosocial Factors in the Burnout of Italian Correctional Officers
Authors: Rania Nadia , Migliorini Laura , Coppola Ilaria
Published: October 2020

Correctional officers (COs) are subject to the development of burnout syndrome. This investigation focuses on those factors that contribute to burnout syndrome in COs who work in Italian penitentiary institutions. Utilizing a qualitative methodology with 50 northern Italian COs, the study finds burnout to be caused by two types of factors, organizational and psychosocial. Notably, the results highlight feelings of anguish, sadness, and abandonment and CO requests for psychological help.
The impact of textile relief structures on pressure distribution and heat transport
Authors: Cieślak Małgorzata , Gromadzińska Ewa , Kamińska Irena , Witczak Ewa , Śledzińska Katarzyna
Published: October 2020

A long-term static position causes inter alia hypoxia, poor blood circulation, slowing down of the metabolism, and problems in air and heat transport, which in consequence lead to the occurrence of bedsores. In the design of seats and mattresses for people with impaired mobility, advanced textile and composite materials should be used to improve safety and comfort. This functionality can be obtained using spatial textile materials. The aim of the research was to assess the impact of two unmodified woven relief structures I.0 and II.0 made of different yarns and ones modified by inserting linear elements (1: braided round tape and 2: polyethylene tube) to their rib tunnel on the heat transport and on the pressure distribution under loading of 0.5, 1, and 2 N. Element 1 lowers the value of average pressure on the fabrics I.1 and II.1, respectively, by 6.9% and 3.5% at the lowest loading and by 9.8% and 4.6% at the highest loading. For fabric II.2 with element 2, the decrease is of 10.4% and 8.4%, respectively. The thermal conductivity values increase by 8.8%, 9.4%, and 40.1%, respectively for I.1, II.1, and II.2. The pressure distribution and thermal characteristic of the fabrics depend on the type of yarn, the structure of ribs, and the linear element and its fit to the rib tunnel.
Skill levels and inequality in migration: A case study of Filipino migrants in the UK
Authors: Hayakawa Tomoko
Published: October 2020

The concept of skill level offers a useful tool to policy-makers and researchers of migration to identify labor market needs, to define the type of migrants needed and to find ways to manage migration. But what this concept entails is often overlooked. This paper problematizes skill level by exploring issues and assumptions associated with its application. Following a review of the UK temporary migration programs, this paper compares the experiences of skilled and low-skilled Filipino migrants in the United Kingdom. The findings indicate that inequality between the two groups can be imposed not just by their job role or circumstances prior to migration but by immigration and social policies of the host country.
Should we patent it or keep it a secret? The moderating role of proactive orientation in family versus non-family SMEs
Authors: Gimenez-Fernandez Elena M , Beukel Karin , Tyler Beverly B , Spielmann Nathalie , Cerrato Daniele , Discua Cruz Allan F , Minciullo Marco
Published: October 2020

We investigate how family and non-family small-and-medium size enterprises (SMEs) differ in their preference for patenting over secrecy as a means to protect value of intellectual property, and how proactive orientation moderates this relationship. Because secrecy carries more risks for spillover than patenting, we propose and provide evidence to suggest that family SMEs are more likely to use patents than secrecy relative to non-family SMEs as a mechanism to protect value. However, proactive orientation can weaken this relationship, since SMEs with a proactive orientation will avoid the disclosure of information required for patenting. Using a sample of 300 SMEs from four countries in the wine industry, we find support for our hypotheses and contribute to both the intellectual property (IP) and SME literatures by explaining how family SMEs relative to non-family SMEs protect the value of IP.
Internationalisation path heterogeneity and growth for international new ventures
Authors: Guo Bin , Wang Zhen
Published: October 2020

An increasing number of new venture firms are internationalising their business operations early in their lifecycles to achieve superior performance. Taking the perspective of dynamic capability theory, our study sheds light on the effect that heterogeneity in experiential learning has on international new venture (INV) growth in terms of a curvilinear relationship. Specifically, we introduce the concept of internationalisation path heterogeneity to capture the path-specific features of INV experiential learning and capability building and explore the relationship between internationalisation path heterogeneity and INV firm growth. We also argue that this relationship will be moderated by environmental munificence because the cost and benefit of path heterogeneity is bounded. We test the hypotheses based on empirical analysis of a longitudinal dataset of 1054 INVs from 58 countries. Overall, this study provides a dynamic and fine-grained view of the role played by internationalisation path heterogeneity in driving the growth of INVs.
Perceptions and experiences of laws and regulations governing access to opioids in South, Southeast, East and Central Asia: A systematic review, critical interpretative synthesis and development of a conceptual framework
Authors: Clark Joseph , Gnanapragasam Sam , Greenley Sarah , Pearce Jessica , Johnson Miriam
Published: October 2020

Background:

Opioids are essential medicines. Despite international and national laws permitting availability, opioid access remains inadequate, particularly in South, Southeast, East and Central Asia.

Aim:

To review evidence of perceptions and experiences of regulatory enablers and barriers to opioid access in South, Southeast, East and Central Asia.

Design:

Systematic review of post-2000 research according to PRISMA guidelines. Data were subjected to critical interpretive synthesis. International, national and sub-national barriers were organised developing a conceptual framework of opioid availability.

Data sources:

PsycINFO, Medline, Embase, The Cochrane Library. CINAHL, Complete and ASSIA from 2000 until 20th May 2019.

Results:

21/14097 studies included: quantitative n = 15, qualitative n = 3 and mixed-methods n = 3. Four barrier/enabler themes were developed: Legal, regulatory, socio-political; lack of laws explicitly enabling opioid access, restrictive international controls and clinician prescribing concerns. Opioid availability; limited availability, poor policymaker and clinician education regarding opioid benefits, poor continuity of supply. Opioid Accessibility; medicine costs, distance to prescribing centres. Prescribing; extensive bureaucratic barriers, lack of human resources for prescribing. We present a novel framework of a self-perpetuating model of inadequate opioid provision. The Single Convention on Narcotics provides the context of restrictive laws and negative attitudes amongst policymakers. A consequent lack of prescribers and clinicians’ negative attitudes at sub-national levels, results in inadequate access to and use of opioids. Data of inadequate consumption informs annual requirement estimates used by the International Narcotics Control Board to determine future opioid availability.

Conclusions:

Regulatory and socio-political actions unintentionally limit opioid access. International and national laws explicitly enabling opioid access are required, to assuage concerns, promote training and appropriate prescribing.
Usefulness of a long sheath in ureteral catheterization after failure of antegrade ureteral stent placement using a short sheath
Authors: Chen Cheng Shi , Kim Jong Woo , Shin Ji Hoon , Li Hai-Liang , Lee Hyung Jin , Ibrahim Alrashidi , Jang Eun Bee
Published: October 2020

Background

When antegrade ureteral intervention fails due to severe ureteral stricture or tortuosity, a longer sheath can be used to facilitate ureteral catheterization.

Purpose

To evaluate the feasibility and effectiveness of the use of a long sheath in antegrade ureteral stent placement after failure of antegrade ureteral stent placement using a short sheath.

Material and Methods

Among 1284 procedures in 934 patients who received ureteral stent placement, a long sheath was used after stricture negotiation failure using a short sheath in 57 (4.4%) procedures in 53 patients. The data of these 53 patients were retrospectively reviewed.

Results

The most common reasons for long sheath use were failure of balloon catheter (59.6%) or guidewire (29.8%) advancement across the stricture. Technical success, successful stricture negotiation after using a long sheath, was achieved in 50/57 (87.7%) procedures. In two of seven failed procedures, an additional TIPS sheath was used and the technical success rate improved to 91.2% (52/57). The technical success rate was significantly higher in the patients who have failed balloon catheter advancement (97.1%, 33/34) than the patients who have failed guidewire advancement (64.7%, 11/17) (Fisher’s exact test, P = 0.004). Self-limiting hematoma occurred in one patient after use of the long sheath and was considered a minor complication.

Conclusion

Ureteral catheterization using a long sheath is feasible and effective when antegrade ureteral intervention using a short sheath fails. When using a long sheath, the technical success rate was higher when advancing the balloon catheter over the guidewire than when advancing the guidewire through tight stricture.
Budd–Chiari syndrome as a complication of eosinophilic granulomatosis with polyangiitis in a young Chinese man: a case report
Authors: Li Dezhao , Shi Chunyu , Ding Zhongyang , Li Xu
Published: October 2020

Hepatic vein thrombosis is a rare occurrence in the clinical course of eosinophilic granulomatosis with polyangiitis (EGPA). The major mechanism of thrombosis has been postulated to involve the release of toxic proteins from eosinophils. A 36-year-old man with EGPA was admitted to our hospital in July 2018 with hematemesis and melena. Findings on physical examination included ascites and pigmentation of the lower extremities. Ultrasonography of the hepatic vein and inferior vena cava showed an obstruction of the hepatic vein. Magnetic resonance imaging showed low enhancement in the right hepatic vein region. At 34 years of age, the patient’s EGPA had initially presented as asthma with eosinophilia (white blood cell count of 11.46 × 1012/L with 14.6% eosinophils). His skin biopsy showed infiltration of inflammatory cells and eosinophils, especially around medium-sized vessels, which was consistent with EGPA. The patient was thus diagnosed with Budd–Chiari syndrome associated with EGPA.
Mental health research in Botswana: a semi-systematic scoping review
Authors: Opondo Philip R. , Olashore Anthony A. , Molebatsi Keneilwe , Othieno Caleb J. , Ayugi James O.
Published: October 2020

Mental and substance use disorders are a leading cause of disability worldwide. Despite this, there is a paucity of mental health research in low- and middle-income countries, especially in sub-Saharan Africa. We carried out a semi-systematic scoping review to determine the extent of mental health research in Botswana. Using a predetermined search strategy, we searched the databases Web of Science, PubMed, and EBSCOhost (Academic Search Complete, CINAHL with Full Text, MEDLINE, MEDLINE with Full Text, MLA International Bibliography, Open Dissertations) for articles written in English from inception to June 2020. We identified 58 studies for inclusion. The most researched subject was mental health aspects of HIV/AIDS, followed by research on neurotic and stress-related disorders. Most studies were cross-sectional and the earliest published study was from 1983. The majority of the studies were carried out by researchers affiliated to the University of Botswana, followed by academic institutions in the USA. There seems to be limited mental health research in Botswana, and there is a need to increase research capacity.
Defining the design requirements for an assistive powered hand exoskeleton: A pilot explorative interview study and case series
Authors: Boser Quinn A , Dawson Michael R , Schofield Jonathon S , Dziwenko Gwen Y , Hebert Jacqueline S
Published: October 2020

Background:

Powered hand exoskeletons are an emerging technology that have shown promise in assisting individuals with impaired hand function. A number of hand exoskeleton designs have been described in the literature; however, the majority have not been supported by patient-oriented criteria.

Objective:

The aim of this study was to define preliminary end-user needs and expectations for an assistive hand exoskeleton.

Study design:

Explorative interview and case series.

Methods:

Six clinicians and eight individuals with impaired hand function were interviewed in small groups or individually. A standardized list of questions was used to elicit feedback on specific design criteria or promote the discovery of new criteria. In addition, three participants with impaired hand function returned for a second session where hand characteristics, such as range of motion and force required to flex/extend fingers, were recorded to further quantify design requirements.

Results:

Interview responses indicated that there was general consensus among participants on criteria relating to important grasp patterns, grip strength, wear time, and acceptable bulk/weight. However, interview responses and hand characteristics also revealed important differences between individuals with impaired hand function.

Conclusion:

Qualitative and quantitative data were collected to develop an understanding of end-user design requirements for assistive hand exoskeletons. Although the data collected were helpful in identifying some preliminary criteria, differences between participants exist and identifying a universal set of criteria applicable across individuals with impaired hand function is challenging. This work reinforces the importance of involving users of rehabilitation technology in the device development process.
Failure of High Flow Nasal Cannula and Subsequent Intubation Is Associated With Increased Mortality as Compared to Failure of Non-Invasive Ventilation and Mechanical Ventilation Alone: A Real-World Retrospective Analysis
Authors: Miller David C. , Pu Jie , Kukafka David , Bime Christian
Published: October 2020

Background:

Despite the increasing use of high flow nasal cannula oxygenation systems (HFNC) in clinical practice, little is known about its role in all cause respiratory failure as compared to traditional non-invasive ventilation (BiPAP). Furthermore, the effect of HFNC on mortality is unknown.

Methods:

We conducted a retrospective analysis of 49,853 patients with respiratory failure treated with non-invasive respiratory support (HFNC or BiPAP) and/or invasive mechanical ventilation (IMV) between 2017 and 2018.

Results:

Patients initially treated with HFNC who underwent subsequent intubation and IMV had a higher mortality rate as compared to patients who were initially treated with BiPAP and underwent subsequent intubation and IMV (34.8% vs 26.3%, p < 0.0001, OR 1.49, 95% CI 1.26,1.76). Patients first treated with HFNC who underwent subsequent intubation and IMV had a significantly increased mortality compared to patients who underwent immediate intubation and IMV (34.8% vs. 21.5%, p ≤ 0.0001, OR 1.94, 95% CI 1.67, 2.27). Stratified based on ICD-10 diagnosis, patients with a diagnosis of COPD exacerbation or heart failure treated with HFNC and subsequent intubation and IMV had higher mortality as compared to those treated with immediate IMV alone. This trend did not hold true for patients with a diagnosis of pneumonia.

Conclusion:

In a real-world retrospective analysis, use of HFNC was associated with increased mortality as compared to BiPAP and IMV alone. Further study is needed to confirm these associations.
Characteristics and Impacts of Sexual Violence Against Men and Boys in Conflict and Displacement: A Multicountry Exploratory Study
Authors: Chynoweth Sarah K. , Buscher Dale , Martin Sarah , Zwi Anthony B.
Published: October 2020

Evidence of sexual violence against men and boys in many conflict-affected settings is increasingly recognized. Yet relatively little is currently known about the varied forms, sites, and impacts of this violence. Further, scant research on sexual violence against men and boys in displacement contexts has been undertaken to date. To begin to address these knowledge gaps, we undertook a multicountry, qualitative, exploratory study to gain insights into these issues. Study settings and populations were Rohingya refugees in Bangladesh; refugees and migrants who had traveled through Libya residing in Italy; and refugees from eastern Democratic Republic of the Congo (DRC), Somalia, and South Sudan residing in Nairobi and Mombasa, Kenya. Methods included 55 semi-structured focus group discussions with 310 refugees and semi-structured key informant interviews with 148 aid workers and human rights experts. Data were thematically analyzed using NVivo 12. Findings suggest that sexual violence against men and boys may not be rare in Myanmar (northern Rakhine state), Libya, eastern DRC, and South Sudan. Frequently reported forms of violence in these settings were genital violence, forced witnessing of sexual violence, and rape. Sites where violence was often reported included border crossings, along the roadside, and during imprisonment. In host countries, forms of sexual violence included sexual abuse of boys, sexual exploitation particularly of adolescents and persons with diverse sexual orientation and gender identity, and rape. Impacts on survivors involved short- and long-term physical, mental, economic, and familial dimensions. These findings aim to inform sexual violence-related prevention, mitigation, and response efforts in humanitarian settings. More research is warranted, including on sexual violence against men and boys in Somalia, sexual violence by family and community members in conflict and displacement settings, sexual exploitation of adolescent boys, and sexual violence including sexual exploitation of persons with diverse sexual orientation and gender identity.
Impact of eCoaching With Video-Based Reflection on Special Education Teacher Candidates’ Instructional Skills
Authors: O’Brien Kristen Merrill , Regan Kelley , Coogle Christan G. , Ottley Jennifer R. , Nagro Sarah A.
Published: October 2020

Clinical experiences are a critical component of teacher preparation programs. Two technology-based approaches used during clinical experiences in special education teacher preparation that have shown promise are eCoaching and video-based reflection. When used in combination as a comprehensive intervention, eCoaching and video-based reflection may offer teacher candidates increased learning opportunities to promote improved fidelity of evidence-based practices. Thus, using a multiple-probe single-case research design, we examined the effect of eCoaching with video-based reflection on special education teacher candidates’ use and quality of target teacher strategies and on focus student responses. We found an increase in the use of target teacher strategies for two of three participants, and an increase in the quality of participants’ strategy implementation and students’ responses for all participants. Participants improved their ability to provide high-quality opportunities for choice making and open-ended responding with consistency. Implications for research and practice are discussed.
Sociodemographic Predictors of Adherence to National Diet and Physical Activity Guidelines at Age 5 Years: The Healthy Start Study
Authors: Bekelman Traci A. , Sauder Katherine A. , Rockette-Wagner Bonny , Glueck Deborah H. , Dabelea Dana
Published: October 2020

Purpose:

To assess adherence to the 2015-2020 Dietary Guidelines for Americans and 2018 Physical Activity Guidelines, and identify sociodemographic predictors of adherence among children.

Design:

Cross sectional.

Setting:

Colorado, United States.

Participants:

Children aged 5 (n = 482).

Measures:

Sex, race/ethnicity, maternal education, maternal employment, maternal subjective social status and household income were assessed via questionnaires. Diet was assessed via 2 interviewer-administered 24-hour dietary recalls. Physical activity was objectively-measured with accelerometry for 7 days. Adherence was defined as a Healthy Eating Index-2015 score of ≥70 and/or ≥6 hours/day of light, moderate and vigorous activity.

Analysis:

For each predictor, logistic regression was used to estimate odds ratios for adherence to the diet guidelines only, the activity guidelines only or both guidelines.

Results:

In the full sample, 29% of children were non-adherent to both guidelines, 6% adhered to the dietary guidelines only, 50% adhered to the activity guidelines only and 14% adhered to both. Girls had a 41% lower odds of adhering to the physical activity guidelines than boys (p = 0.01), after adjustment for race/ethnicity, household income and maternal education level, perceived social status and employment status.

Conclusion:

Efforts to improve the health of young children should promote adherence to the Dietary Guidelines for Americans among all children. Targeted interventions that increase physical activity among girls may help to mitigate health disparities.
Changing Patterns of Peritoneal Dialysis Utilization in the United States
Authors: Mehrotra Rajnish
Published: October 2020

The proportion of incident U.S. patients with end-stage renal disease starting chronic peritoneal dialysis (CPD) has historically been low. The low take-on for CPD in the United States is likely multifactorial, but limited physician training and inadequate pre-dialysis patient education appear to be particularly important. Furthermore, two key changes have occurred in the United States: a steep decline in CPD take-on and a progressive increase in the use of automated peritoneal dialysis (APD). The decline in CPD take-on has affected virtually every subgroup examined and has occurred, paradoxically, when the CPD outcomes in the country have improved. Understanding the reasons for historically low CPD take-on and recent steep declines in utilization may allow for plans to reverse these trends to be developed.
Cell Therapy in Kidney Disease: Cautious Optimism … But Optimism Nonetheless
Authors: Zenovich Andrey G. , Taylor Doris A.
Published: October 2020

The recently discovered therapeutic potential of stem or progenitor cells has initiated development of novel treatments in a number of diseases—treatments that could not only improve patients’ quality of life, but also halt or even prevent disease progression. Hypertension; fluctuations in glycemia, electrolytes, nutrient levels, and circulating volume; and frequent infections and the associated inflammation all greatly impair the endothelium in patients undergoing peritoneal dialysis. As our understanding of the regulatory function of the endothelium advances, focus is increasingly being placed on endothelial repair in acute and chronic renal failure and after renal transplantation. The potential of progenitor cells to repair damaged endothelium and to reduce inflammation in patients with renal failure remains unexamined; however, a successful cell therapy could reduce morbidity and mortality in kidney disease.

Important contributions have been made in identifying progenitor cell populations in the kidney, and further investigations into the relationships of these cells with the pathophysiology of the disease are underway. As the kidney disease field prepares for the first human trials of progenitor cell therapies, we deemed it important to review representative original research, and to share our perspectives and lessons learned from clinical trials of progenitor cell–based therapies that have commenced in patients with cardiovascular disease.
Automated Peritoneal Dialysis in Children and Adolescents—Benefits: A Survey of Patients and Parents on Health-Related Quality of Life
Authors: Chiu Man-Chun , Ng Cherry Fai-Ngor , Lee Lai-Ping , Lai Wai-Ming , Lau Shing-Chi
Published: October 2020

Automated peritoneal dialysis (APD) benefits children on dialysis and their parents by allowing for more daytime freedom and a more normal life. We carried out a survey on health-related quality of life (HRQOL) in children and adolescents from our end-stage renal disease program, including those on APD and hemodialysis (HD), and those who had received a kidney transplant (TX). Parents of patients under 18 years of age were also interviewed. The questionnaire on QOL was adapted from the Pediatric Quality of Life Inventory and grouped into seven aspects for which patients and parents were asked to assess the frequency of related problems during the preceding 3 months. We surveyed eligible children among the APD, HD, and TX patients enrolled in our program, and we surveyed the parents of the patients under 18 years of age. For APD, patients and parents both gave their most favorable scores to the peer activities and relationships and family activities and relationships aspects. In the TX group, the family activities and relationships aspect was also scored most favorably of all aspects. Notably, we observed no significant difference between the total scores for the APD and TX groups among patients and parents alike. Although the survey provided only a “snapshot” of HRQOL, the assessment by APD patients and their parents seems to be comparable to that by TX patients and their parents.
Maximizing the Success of Peritoneal Dialysis in High Transporters
Authors: Li Philip Kam-Tao , Chow Kai Ming
Published: October 2020

This article reviews the current understanding of high transport status in the peritoneal dialysis population and emphasizes survival can be improved for high transporters. To address the current state of knowledge on high peritoneal membrane transport, the negative impact of an increased peritoneal solute transport rate is first discussed. The potential downside of high transport status, notably on survival outcomes (as supported by registry data and meta-analysis), is highlighted. Based on recent advances and clinical studies, ways of maximizing the success of peritoneal dialysis treatment in high transporters are discussed, and management strategies are proposed.
Therapeutic Options for Preservation of Residual Renal Function in Patients on Peritoneal Dialysis
Authors: Li Philip KamTao , Cheng Yuk Lun
Published: October 2020

Dialysis is not the ideal renal replacement therapy because it does not fully restore all kidney functions. Increasing evidence suggests that preservation of residual renal function is associated with a survival benefit, a decrease in morbidity, better nutrition, a lower level of inflammatory markers, an improved quality of life, and cost savings by obviating the need for more peritoneal dialysis exchanges and possibly by reducing the requirement for antihypertensive agents, phosphate binders, and erythropoietin. In the present article, we review the impact of residual renal function on patient outcomes and the renoprotective strategies available in patients on peritoneal dialysis.
Good Patient and Technique Survival in Elderly Patients on Continuous Ambulatory Peritoneal Dialysis
Authors: Li Philip Kam-Tao , Law Man Ching , Chow Kai Ming , Leung Chi-Bon , Kwan Bonnie Ching-Ha , Chung Kwok Yi , Szeto Cheuk-Chun
Published: October 2020

The aging population has significant implications for the community. The increasing number of elderly end-stage renal disease (ESRD) patients presses the renal team to find an appropriate management plan. We used a retrospective analysis to study the effectiveness of continuous ambulatory peritoneal dialysis (CAPD) in elderly ESRD patients. Of the 328 CAPD patients recruited for the study, 121 were in the elderly group (≥ 65 years of age), and 207 were in the control group (under 65 years of age). Median age in the elderly group was 71 years, and in the control group, 51 years. The elderly group had a higher prevalence (54.5%) of diabetes mellitus. The 2-year and 5-year rates of patient survival were 89.3% and 54.8% respectively in the elderly group and 92.2% and 62.9% in the control group ( p = 0.19). The 2-year and 5-year rates of technique survival were 84.0% and 45.7% respectively in the elderly group and 80.9% and 49.1% in the control group ( p = 0.75). The probability of a 12-month peritonitis-free period was 76.6% in the elderly group and 76.5% in the control group ( p = 0.75).

One hundred elderly patients (82.6% of the group) performed their CAPD exchanges by themselves. We observed no significant difference in clinical outcome—including patient survival, technique survival, and peritonitis-free period—between the elderly self-care CAPD and the elderly assisted CAPD groups.

In elderly ESRD patients, CAPD is an effective dialysis modality. A slightly longer training time is to be expected for elderly patients. Self-care CAPD for elderly patients who are capable of performing their own exchanges provides them with an independent home life.
Risk Factors for Cardiovascular Disease in Patients Undergoing Peritoneal Dialysis
Authors: García–López Elvia , Carrero Juan J. , Suliman Mohamed E. , Lindholm Bengt , Stenvinkel Peter
Published: October 2020

Patients on peritoneal dialysis (PD) are at high cardiovascular risk. Although some risk factors are unmodifiable (for example, age, sex, genetics), others are exacerbated in the unfriendly uremic milieu (inflammation, oxidative stress, mineral disturbances) or contribute per se to kidney disease and cardiovascular progression (diabetes mellitus, hypertension). Moreover, several factors associated with PD therapy may both increase (by altered lipid profile, hyperinsulinemia, and formation of advanced glycation end-products) and decrease (by better blood pressure control and anemia management) cardiovascular risk. The present review discusses recent findings and therapy trends in cardiovascular research on the PD population, with emphasis on the roles of inflammation, insulin resistance, homocysteinemia, dyslipidemia, vascular calcification, and genetics/epigenetics.
An Overview of the Pathophysiology of Vascular Calcification in Chronic Kidney Disease
Authors: Stompór Tomasz
Published: October 2020

Abnormalities of calcium–phosphate balance, with subsequent bone metabolism disorders, are among the key and earliest features of chronic kidney disease (CKD). Recently, another consequence of these abnormalities was brought to light—namely, vascular calcification. Most studies performed in patients on dialysis suggest that their vascular calcification is more advanced than that seen in the general population. Furthermore, the progression of vessel wall mineralization is much more dynamic in patients with CKD.

Apart from the commonly assessed factors that promote vascular calcification, such as age, duration of dialysis, or poor control of calcium–phosphate status, several other factors have recently been identified. In the spectrum of substances involved in the regulation of the process of soft-tissue calcification, the most extensively studied in the nephrology literature are bone morphogenetic protein 7, osteoprotegerin, matrix Gla protein, fetuin-A, and the phosphatonins. Better understanding of the mechanisms underlying excess vascular mineralization have led to the development of promising new therapies.
Intravenous versus Oral Iron Supplementation in Peritoneal Dialysis Patients
Authors: Johnson David W.
Published: October 2020

Iron supplementation is required in a preponderance of peritoneal dialysis (PD) patients treated with erythropoietic stimulatory agents (ESAs). Although many authors and clinical practice guidelines recommend primary oral iron supplementation in ESA-treated PD patients, numerous studies have clearly demonstrated that, because of a combination of poor bioavailability of oral iron, gastrointestinal intolerance, and noncompliance, oral iron supplementation is insufficient for maintaining a positive iron balance in these patients over time. Controlled trials have demonstrated that, in iron-deficient and iron-replete PD patients alike, intravenous (IV) iron supplementation results in superior iron stores and hemoglobin levels with fewer side effects than oral iron produces. Careful monitoring of iron stores in patients receiving IV iron supplementation is important in view of conflicting epidemiologic links between IV iron loading and infection and cardiovascular disease. Emerging new iron therapies such as heme iron polypeptide and ferumoxytol may further enhance the tolerability, efficacy, and ease of administration of iron in PD patients.
Optimization of Peritoneal Dialysis Services through Research Activities
Authors: Tan Si-Yen
Published: October 2020

Although peritoneal dialysis (PD) is an effective alternative to hemodialysis (HD) and indeed, in terms of survival, superior to HD in first year of dialysis, the utilization rate for PD remains low. Although the utilization rate of PD varies considerably, the worldwide penetration rate appears to be falling. Still, in rapidly developing countries such as China, the PD penetration rate is rising—an encouraging sign. Clearly, considerable room for improvement remains, particularly with the take-on rate of PD, and one of the potentially influential factors is the role of research activities in improving both the quantity and quality of life of patients on PD.