bluuebunny/crossref_metadata_2025 huggingface dataset:
Retaining Participants in Outpatient and Community-Based Health Studies
Authors: Odierna Donna H. , Bero Lisa A.
Published: January 2017

Loss to follow-up can introduce bias into research, making it difficult to develop inclusive evidence-based health policies and practice guidelines. We aimed to deepen understanding of reasons why participants leave or remain in longitudinal health studies. We interviewed 59 researchers and current and former research participants in six focus groups ( n = 55) or interviews ( n = 4) at three study centers in a large academic research institution. We used minimally structured interview guides and inductive thematic analysis to explore participant-level, study-level, and contextual participation barriers and facilitators. Four main themes emerged: transportation, incentives and motivation, caregiver concerns, and the social and physical environment. Themes shared crosscutting issues involving funding, flexibility, and relationships between researchers and research participants. Study-level and contextual factors appear to interact with participant characteristics, particularly socioeconomic status and disease severity to affect participant retention. Participants’ characteristics do not seem to be the main cause of study dropout. Researchers and funders might be able to address contextual and study factors in ways that reduce barriers to participation.
Understanding the Implementation of Knowledge Management in High-Performance Schools in Malaysia
Authors: Ab. Samad Rahmad Sukor , Rahmad Sukor Mohamed Iskandar , Syah Darwyan , Muslihah Eneng
Published: January 2017

This study intends to assess the implementation of policies in high-performance schools (HPS). One hundred fifty-two administrators in 52 HPS were selected using full sampling. Only two factors serve as contributors in knowledge management model for high-performing schools in Malaysia, which were school culture and school strategy. Whereas the correlation indicated that all 10 factors, namely, mission and vision, school strategy, school culture, intellectual modal, learning organization, leadership management, teamwork and learning community, knowledge sharing, new knowledge generation, and digital advancement, have significant relationships with the understanding of knowledge management, at different levels.
Comparing Efficacy of Instructional Approaches to Develop Environmental Awareness Among School Students
Authors: D’Souza Doris , Sharma Durga , Singh R. P.
Published: January 2017

This study aims to compare efficacy of self-learning, audiovisual, and fun activity instructional approaches among school students of Patna, the capital city of Bihar state of India, to develop environmental awareness. The study participants include 144 randomly selected students (72 girls and 72 boys) from eight different schools of Patna. During a weeklong environmental awareness program, students were instructed using above three approaches of instruction. Data have been analyzed by using linear regression. Regression was carried out to eliminate the effect of general mental ability (GMA) scores. The results suggest about overall superiority of fun activity approach over other approaches tested in the present study. However, awareness gain has been significant among the students with high GMA when instructed through audiovisual approach.
Farming in an Agriburban Ecovillage Development
Authors: Newman Lenore , Nixon Denver
Published: January 2017

A growing desire for local food systems has increased interest in peri-urban farming, leading to the rise of agriburban landscapes, in which a desire to farm or to be near farmland is a contributing factor to development patterns. Interviews and site visits to the Yarrow Ecovillage near Vancouver, Canada, outline an example of a development that allows new farmers access to land in a setting with few tensions between farming and non-farming residents in a zone on the edge of a protected agricultural region. Although there are limitations to replication of this model, we suggest that intentional settlements with an agricultural element on the rural/urban fringe could buffer traditional tensions between farm usage and residential usage, while allowing small-scale farmers a place to farm in areas with prohibitively high land values.
The Gulf Cooperation Council
Authors: Tompkins Olga
Published: January 2017

The Gulf Cooperation Council was formed in 1981 to create economic, scientific, and business cooperation among its members. The opportunity exists for scientific collaboration on nursing education, practice, and research.
Farm Elders Define Health as the Ability to Work
Authors: Reed Deborah B. , Rayens Mary Kay , Conley Christina K. , Westneat Susan , Adkins Sarah M.
Published: January 2017

Thirty percent of America's 2.2 million farms are operated by individuals older than 65 years. This study examined how older farmers define health and determined whether demographic characteristics, farm work, and physical and mental health status predict health definition. Data were collected via telephone and mailed surveys during the baseline wave of data collection in a longitudinal study of family farmers residing in two southern states ( n = 1,288). Nearly 42% defined health as the “ability to work” compared to a physical health-related definition. Predictors of defining health as the ability to work included being White, performing more farm tasks in the past week, taking prescription medications daily, and having minimal health-related limitations to farm work. Health behaviors are centered on the individual's perception of health. Understanding the defining attributes of health can support better approaches to health care and health promotion, particularly among rural subcultures such as farmers, whose identity is rooted in their work.
Building a Health Literate Workplace
Authors: Wong Bet Key
Published: January 2017

Approximately 36% of America's adult population cannot perform daily activities that require basic reading, writing, and numeric skills. Individuals who are at risk for low health literacy have demographics and socioeconomic backgrounds similar to those of individuals considered vulnerable by the National Occupational Research Agenda (NORA). Improving health literacy is a public health priority. Occupational health nurses can play a major role in assisting employers to build a health literate organization while improving the health of their employees. This article discusses attributes of a health literate organization, including organizational commitment, infrastructure, policies and practices with a health literacy priority, and effective communication at all levels.
Associations between Obesity and Stress and Shift Work among Nurses
Authors: Buss Julia
Published: January 2017

Nurses' work is known to be stressful, and many nurses work shifts. Both stress and shift work are factors that can influence how and what nurses eat and may increase nurses' risk for weight gain and obesity. This literature review summarizes the evidence regarding the prevalence of obesity and overweight among nurses who work shifts and examine associations between stress and the eating behaviors of these nurses. The conclusion provides some implications for occupational health nurses who promote wellness for their employees.
Implementation of a Safe Driver Program
Authors: Randolph Susan A.
Published: January 2017

Occupational and environmental health nurses can assist in developing a driver safety program to increase awareness of the effects of impaired driving.
Hemophagocytic Lymphohistiocytosis in a Patient With Hodgkin lymphoma and Concurrent EBV, CMV, and Candida Infections
Authors: Mustafa Ali Moaath , Ruano Mendez Ana Lucia , Carraway Hetty E.
Published: January 2017

Hemophagocytic lymphohistiocytosis (HLH) is a syndrome characterized by immune activation and subsequent widespread organ damage. Patients affected by HLH commonly develop fever, cytopenias, liver damage, neurologic manifestations, and hypercytokinemia. In this case, we describe a 60-year-old male who presented with HLH and concurrent Epstein-Barr virus, cytomegalovirus, and Candida infections and was subsequently diagnosed with a Hodgkin lymphoma. This case highlights the importance of considering a cancer diagnosis in the differential diagnosis of patients presenting with HLH.
Anomalous Origin of the Left Coronary Artery From the Pulmonary Artery
Authors: Gangadharan Venkat , Sivagnanam Kamesh , Murtaza Ghulam , Ponders Michael , Teixeira Otto , Paul Timir
Published: January 2017

A 36-year-old woman was seen with complaints of exertional chest pain and shortness of breath. Her medical history included atrial fibrillation and diabetes. Physical examination was unremarkable except for an irregular cardiac rhythm. Myocardial perfusion imaging revealed the presence of a large area of infarction involving the entire anterior and apical walls and part of the anteroseptal wall with minimal periinfarct ischemia. Computed tomography coronary angiogram revealed an anomalous left main coronary artery arising from the main pulmonary artery. Right and left heart catheterizations demonstrated moderate pulmonary hypertension with a slight step-up in oxygen saturation between the right ventricle and main pulmonary artery. Coronary angiography showed a large tortuous right coronary artery with collaterals to the left anterior descending artery that drained into the main pulmonary artery. She was referred for surgery. This case demonstrates a rare coronary artery anomaly in an adult where survival is dependent on collateral circulation.
The Circuitries of Spectral Urbanism: Looking Underneath Fantasies in Luanda’s New Centralities
Authors: Cardoso Ricardo
Published: January 2017

The study of Africa’s new developments and satellite cities has been mostly led under the fundamentally aesthetic typology of ‘urban fantasies’. This provides important elements for a critique of how speculative idioms have been tainting contemporary forms of urban development across the continent, but it does not allow us to apprehend them as modes of city making with particular histories, practices and toolkits. This article leans on the Angolan example to contend with that typology. Drawing on an in-depth study of urban development in contemporary Luanda and its relationship with the Angolan oil complex, it does so in three moments. First, it presents a brief overview of what, in the recent years, has become one of the leading ways of critically assessing urban worlding projects in the African context. Second, it uses an introductory viewpoint into Luanda’s ‘new centralities’ project to contribute towards an improved and more nuanced understanding of what underpins and constitutes the envisioned futures of African cities. And third, it reconsiders and fine-tunes some of the main premises on which the study of Africa’s emerging forms of urban development has been carried out thus far.
Safety and efficacy of allogeneic hematopoietic stem cell transplant after PD-1 blockade in relapsed/refractory lymphoma
Authors: Merryman Reid W. , Kim Haesook T. , Zinzani Pier Luigi , Carlo-Stella Carmelo , Ansell Stephen M. , Perales Miguel-Angel , Avigdor Abraham , Halwani Ahmad S. , Houot Roch , Marchand Tony , Dhedin Nathalie , Lescaut Willy , Thiebaut-Bertrand Anne , François Sylvie , Stamatoullas-Bastard Aspasia , Rohrlich Pierre-Simon , Labussière Wallet Hélène , Castagna Luca , Santoro Armando , Bachanova Veronika , Bresler Scott C. , Srivastava Amitabh , Kim Harim , Pesek Emily , Chammas Marie , Reynolds Carol , Ho Vincent T. , Antin Joseph H. , Ritz Jerome , Soiffer Robert J. , Armand Philippe
Published: January 2017

Key Points

HSCT after PD-1 blockade is feasible, although may be associated with increased early immune toxicity. PD-1 blockade may cause persistent depletion of PD1+ T cells and alterations in T-cell differentiation impacting subsequent treatment.
The dangers of parathyroid biopsy
Authors: Kim Joanne , Horowitz Gilad , Hong Michael , Orsini Mario , Asa Sylvia L. , Higgins Kevin
Published: January 2017

Background

We report an unusual case of a 66-year-old female with a suspicious thoracic outlet mass presenting with severe biochemical hyperparathyroidism and classic hypercalcemic symptoms of renal and bone involvement.

Case Presentation

There was clinical suspicion for parathyroid carcinoma, further supported by intra-operative findings. However, the final pathology described a primary hyperceullar parathyroid lesion with pathognomonic changes secondary to fine-needle aspiration (FNA) biopsy, along with a separate parathyroid lesion likely resulting from seeding along the needle tract. Upon further review, record of a remote FNA was discovered. This case highlights the complications associated with parathyroid FNA resulting in a diagnostic challenge and raising the possibility of malignancy.

Conclusions

We therefore recommend to take caution when there is a prior parathyroid FNA, as it can present with the risks of a secondary lesion from seeding and increase resemblance of malignancy both clinically and through pathologic diagnosis.
Smell of heritage: a framework for the identification, analysis and archival of historic odours
Authors: Bembibre Cecilia , Strlič Matija
Published: January 2017

We don’t know much about the smells of the past. Yet, odours play an important role in our daily lives: they affect us emotionally, psychologically and physically, and influence the way we engage with history. Can this lead us to consider certain smells as cultural heritage? And if so, what would be the processes for the identification, protection and conservation of those heritage smells? In order to answer these questions, the connection between olfaction and heritage was approached in three ways: (1) through theoretical analysis of the concept and role of olfaction in heritage guidelines, leading to identification of places and practices where smell is fundamental to their identity, (2) through exploration of the evidence for use of smells in heritage as a tool to communicate with audiences; and (3) through experimental evaluation of the techniques and methods for analysing and archiving the smells, therefore enabling their documentation and preservation. We present this through the framework of Significance Assessment—Chemical Analysis—Sensory Analysis—Archiving. The smell of historic paper was chosen as the case study, based on its well-recognized cultural significance and available research. Odour characterization was achieved by collecting visitor descriptions of a historic book extract through a survey, and by conducting a sensory evaluation at a historic library. These were combined with the chemical information on the VOCs sampled from both a historic book and a historic library, to create the Historic Book Odour Wheel, a novel documentation tool representing the first step towards documenting and archiving historic smells.
Deficiency of N-myristoylation reveals calcineurin activity as regulator of IFN-γ-producing γδ T cells
Authors: Rampoldi Francesca , Brunk Fabian , Bonrouhi Mahnaz , Federico Giuseppina , Krunic Damir , Porubsky Stefan , Gröne Hermann-Josef , Popovic Zoran V
Published: January 2017

γδ T cell subsets can be characterized, in part, by their secretion of select proinflammatory cytokines. The molecular mechanisms driving the diverse fates of γδ T cells have not been elucidated. We have previously shown that the attachment of myristic acid to the N-terminal glycine of proteins, termed N-myristoylation, is essential for αβ T cell development and activation. Here, we explore the potential role of this lipid modification on the activation of γδ T cells. In the absence of N-myristoylation, the CD27+ γδ T cell subset was dominantly affected. The cells produced high levels of IFN-γ upon stimulation. In addition, they were more sensitive to inhibition of the CaN-Nfat pathway than were γδ T cells with myristoylated CaN. N-Myristoylation was found to modulate activity of phosphatase CaN, a regulator of Nfat. In summary, the CaN–Nfat pathway regulates development and function of IFN-γ-producing γδ T cells, and its balanced activity is strongly dependent on CaN N-myristoylation.
Impact of Systemic Vascular Resistance on the Accuracy of the Pulsioflex Device
Authors: Biais Matthieu , Mazocky Elodie , Stecken Laurent , Pereira Bruno , Sesay Musa , Roullet Stéphanie , Quinart Alice , Sztark François
Published: January 2017

BACKGROUND:

The accuracy of currently available devices using pulse contour analysis without external calibration for cardiac index (CI) estimation is negatively impacted by hyperdynamic states, low systemic vascular resistance (SVR), and abrupt changes in SVR. The aim of this study was to evaluate the accuracy of a new device, the Pulsioflex (Pulsion Medical System), in patients undergoing liver transplantation.

METHODS:

Thirty consecutive patients scheduled for liver transplantation were included. CI was monitored using pulmonary arterial catheter (CI-PAC) and Pulsioflex (CI-Pulsio). Simultaneous CI measurements were made intraoperatively at 9 different stages of the procedure.

RESULTS:

Two hundred seventy pairs of measurements were analyzed. The median CI-Pulsio values (3.3; interquartile range, 2.8–3.8 L·min−1·m2) were significantly different from the median CI-PAC (4.1; interquartile range, 3.1–5.0 L·min−1·m2; P < .0001). Bland and Altman analysis showed a mean bias of 0.8 L·min−1·m2 and 95% limit of agreement from −2.5 to 4.1 L·min−1·m2. Percentage error was 65% (95% confidence interval, 60%–71%). Considering the variations in CI between 2 stages, the comparison between changes in CI-PAC and changes in CI-Pulsio showed a mean bias of 0.1 L·min−1·m2 and 95% limit of agreement of −2.1 to 2.2 L·min−1·m2. When excluding changes in CI <0.5 L·min−1·m2 (154 paired analyzed), the concordance rate was 62% (95% confidence interval, 54%–70%). The bias between CI-PAC and CI-Pulsio was negatively correlated with SVR (r = −0.67, P < .0001). The bias between changes in CI-PAC and changes in CI-Pulsio was also negatively correlated with changes in SVR (r = −0.52, P < .0001).

CONCLUSIONS:

In patients undergoing liver transplantation, Pulsioflex does not accurately estimate CI. Its accuracy is highly impacted by SVR, and it is not able to track changes in CI when large variations in SVR occur.
Time- and Dose-Dependent Effects of Desflurane in Sensitized Airways
Authors: Zhou Jing , Iwasaki Sohshi , Yamakage Michiaki
Published: January 2017

BACKGROUND:

Although the bronchodilatory actions of volatile anesthetics, such as halothane, isoflurane, and sevoflurane, have been well documented in previous studies, the properties of desflurane remain controversial. The aim of this study was to investigate the effects of desflurane at different concentrations and durations in an ovalbumin-sensitized guinea pig model of airway hyper-responsiveness.

METHODS:

Ovalbumin-sensitized animals (n = 176) were randomly assigned to 5 groups according to the minimum alveolar concentration (MAC) of desflurane they received: 0.0, 0.5, 1.0, 1.5, and 2.0 MAC. Total lung resistance in vivo, airway smooth muscle tension in vitro, and intracellular cyclic adenosine monophosphate (AMP) levels were measured to evaluate the effects of desflurane.

RESULTS:

In 5 sensitized groups, total lung resistance increased from baseline to peak at approximately 8 minutes and then decreased slowly until about 17 minutes with extended administration of desflurane. Desflurane dose-dependently increased total lung resistance with or without incremental doses of acetylcholine and reduced muscle tension with increasing concentrations of carbacholine. Cyclic AMP levels were increased by desflurane: at the 60-minute time point, cyclic AMP concentrations (means ± SD) with 0.5 MAC (1.96 ± 0.40) and 1.0 MAC (2.11 ± 0.50) desflurane were higher than those at the 8-minute time point (1.11 ± 0.23 and 1.32 ± 0.32).

CONCLUSIONS:

Desflurane exerted time- and dose-dependent effects and could be used at 0.5 and 1.0 MAC concentrations without significant bronchoconstriction in ovalbumin-sensitized guinea pigs. Cyclic AMP-mediated airway smooth muscle relaxation might be one mechanism by which desflurane induces bronchodilation.
In Vogue: Ketamine for Neuroprotection in Acute Neurologic Injury
Authors: Bell Josh D.
Published: January 2017

Neurologic deterioration following acute injury to the central nervous system may be amenable to pharmacologic intervention, although, to date, no such therapy exists. Ketamine is an anesthetic and analgesic emerging as a novel therapy for a number of clinical entities in recent years, including refractory pain, depression, and drug-induced hyperalgesia due to newly discovered mechanisms of action and new application of its known pharmacodynamics. In this focused review, the evidence for ketamine as a neuroprotective agent in stroke, neurotrauma, subarachnoid hemorrhage, and status epilepticus is highlighted, with a focus on its applications for excitotoxicity, neuroinflammation, and neuronal hyperexcitability. Preclinical modeling and clinical applications are discussed.
Fox transcription factors: from development to disease
Authors: Golson Maria L. , Kaestner Klaus H.
Published: January 2017

Forkhead box (Fox) transcription factors are evolutionarily conserved in organisms ranging from yeast to humans. They regulate diverse biological processes both during development and throughout adult life. Mutations in many Fox genes are associated with human disease and, as such, various animal models have been generated to study the function of these transcription factors in mechanistic detail. In many cases, the absence of even a single Fox transcription factor is lethal. In this Primer, we provide an overview of the Fox family, highlighting several key Fox transcription factor families that are important for mammalian development.
Transcriptional regulation of intermediate progenitor cell generation during hippocampal development
Authors: Harris Lachlan , Zalucki Oressia , Gobius Ilan , McDonald Hannah , Osinki Jason , Harvey Tracey J. , Essebier Alexandra , Vidovic Diana , Gladwyn-Ng Ivan , Burne Thomas H. , Heng Julian I. , Richards Linda J. , Gronostajski Richard M. , Piper Michael
Published: January 2017

During forebrain development, radial glia generate neurons through the production of intermediate progenitor cells (IPCs). The production of IPCs is a central tenet underlying the generation of the appropriate number of cortical neurons, but the transcriptional logic underpinning this process remains poorly defined. Here, we examined IPC production using mice lacking the transcription factor nuclear factor I/X (Nfix). We show that Nfix deficiency delays IPC production and prolongs the neurogenic window, resulting in an increased number of neurons in the postnatal forebrain. Loss of additional Nfi alleles (Nfib) resulted in a severe delay in IPC generation while, conversely, overexpression of NFIX led to precocious IPC generation. Mechanistically, analyses of microarray and ChIP-seq datasets, coupled with the investigation of spindle orientation during radial glial cell division, revealed that NFIX promotes the generation of IPCs via the transcriptional upregulation of inscuteable (Insc). These data thereby provide novel insights into the mechanisms controlling the timely transition of radial glia into IPCs during forebrain development.
A proteomic approach to identify endosomal cargoes controlling cancer invasiveness
Authors: Diaz-Vera Jesica , Palmer Sarah , Hernandez-Fernaud Juan Ramon , Dornier Emmanuel , Mitchell Louise E. , Macpherson Iain , Edwards Joanne , Zanivan Sara , Norman Jim C.
Published: January 2017

We have previously shown that Rab17, a small GTPase associated with epithelial polarity, is specifically suppressed by ERK2 (also known as MAPK1) signalling to promote an invasive phenotype. However, the mechanisms through which Rab17 loss permits invasiveness, and the endosomal cargoes that are responsible for mediating this, are unknown. Using quantitative mass spectrometry-based proteomics, we have found that knockdown of Rab17 leads to a highly selective reduction in the cellular levels of a v-SNARE (Vamp8). Moreover, proteomics and immunofluorescence indicate that Vamp8 is associated with Rab17 at late endosomes. Reduced levels of Vamp8 promote transition between ductal carcinoma in situ (DCIS) and a more invasive phenotype. We developed an unbiased proteomic approach to elucidate the complement of receptors that redistributes between endosomes and the plasma membrane, and have pin-pointed neuropilin-2 (NRP2) as a key pro-invasive cargo of Rab17- and Vamp8-regulated trafficking. Indeed, reduced Rab17 or Vamp8 levels lead to increased mobilisation of NRP2-containing late endosomes and upregulated cell surface expression of NRP2. Finally, we show that NRP2 is required for the basement membrane disruption that accompanies the transition between DCIS and a more invasive phenotype.
Interplay between a cytosolic and a cell surface carbonic anhydrase in pH homeostasis and acid tolerance of Leishmania
Authors: Pal Dhiman Sankar , Abbasi Mazharul , Mondal Dipon Kumar , Varghese Binitha Anu , Paul Ritama , Singh Shalini , Datta Rupak
Published: January 2017

Leishmania parasites have evolved to endure the acidic phagolysosomal environment within host macrophages. How Leishmania cells maintain near-neutral intracellular pH and proliferate in such a proton-rich mileu remains poorly understood. We report here that, in order to thrive in acidic conditions, Leishmania major relies on a cytosolic and a cell surface carbonic anhydrase, LmCA1 and LmCA2, respectively. Upon exposure to acidic medium, the intracellular pH of the LmCA1+/−, LmCA2+/− and LmCA1+/−:LmCA2+/− mutant strains dropped by varying extents that led to cell cycle delay, growth retardation and morphological abnormalities. Intracellular acidosis and growth defects of the mutant strains could be reverted by genetic complementation or supplementation with bicarbonate. When J774A.1 macrophages were infected with the mutant strains, they exhibited much lower intracellular parasite burdens than their wild-type counterparts. However, these differences in intracellular parasite burden between the wild-type and mutant strains were abrogated if, before infection, the macrophages were treated with chloroquine to alkalize their phagolysosomes. Taken together, our results demonstrate that haploinsufficiency of LmCA1 and/or LmCA2 renders the parasite acid-susceptible, thereby unravelling a carbonic anhydrase-mediated pH homeostatic circuit in Leishmania cells.
Total Laparoscopic Aortomesenteric Bypass
Authors: Javerliat Isabelle , Coggia Marc , Bourriez Armand , Di Centa Isabelle , Cerceau Pierre , Goëau-Brissonnière Olivier A
Published: January 2017

We describe what we believe to be the first case of C-loop aortomesenteric total laparoscopic bypass. This bypass was combined with a total laparoscopic aortofemoral bypass. The approach to the superior mesenteric artery used a partial left medial visceral rotation after a left retrocolic dissection.
Sexual Dysfunction in Men after Open or Endovascular Repair of Abdominal Aortic Aneurysms
Authors: Jimenez Juan Carlos , Smith Melissa M. , Wilson Samuel Eric
Published: January 2017

Few studies have thoroughly investigated the incidence and detailed the degree of sexual disability after aortic aneurysm surgery. Reports prior to 1990 vary greatly in the incidence of postoperative dysfunction mostly because of nonstandardized methods of assessment. In this article, we compare the incidence of reported sexual dysfunction after aortic reconstruction, open and endovascular abdominal aortic aneurysm repair. Pertinent studies on sexual dysfunction following open and endovascular aortic aneurysm repair were identified from a MEDLINE search of English-language publications since 1966. Newer standardized methods of assessment have identified relatively high rates of sexual dysfunction prior to and after intervention. Aortic aneurysm patients have a baseline incidence of sexual dysfunction of approximately 30%, which doubles over the next 7 years. Patients who had open aortic operations reported significantly increased sexual dysfunction during the first postoperative year. Endovascular repair with unilateral internal iliac occlusion results in new sexual dysfunction in approximately 10% of patients, but this increases significantly with bilateral internal iliac occlusion. When compared with open operation, the incidence of sexual dysfunction is lower overall in patients with endovascular aortic aneurysm repairs, which includes those who have internal iliac artery occlusion, but it is increased with bilateral iliac occlusion. Surgeons should be aware of the preoperative prevalence of sexual dysfunction in patients undergoing aortic procedures.
Molecular identification of endophytic fungi isolated from the tuber of Dahlia variabilis and exploration of their ability in producing ÃŸ-galactosidase
Authors: SARYONO SARYONO , RAKHMANA SENJAVI , RAHAYU FITRI , ARDHI AULIA , RUSLI RUSLI , PRATIWI NOVA WAHYU , NUGROHO TITANIA T.
Published: January 2017

Abstract. Saryono, Rakhmana S, Rahayu F, Ardhi A, Rusli, Pratiwi NW, Nugroho TT. 2017. Molecular identification of endophytic fungi isolated from the tuber of Dahlia variabilis and exploration of their ability in producing ÃŸ-galactosidase. Biodiversitas 18: 145-152.LBKURCC67 and LBKURCC69 were endophytic fungi isolated from the tubers of dahlia (Dahlia variabilis) in Padang Panjang, West Sumatra. This study aimed to identify the microscopic and molecular characteristics of endophytic fungi LBKURCC67 and LBKURCC69 based on ITS-rDNA region sequences and determine the ability of the isolates to produce Î²-galactosidase. Microscopic characteristic of LBKURCC67 and LBKURCC69 indicated that both isolates belonged to Fusarium sp. Furthermore, DNA sequence analysis based on mega BLAST program showed that LBKURCC67 was identified to be Fusarium solani with 99% homology and LBKURCC69 showed the perfect homology similarity with Fusarium oxysporum. Meanwhile, Î²-galactosidase activity was determined based on the amount of o-nitrophenol produced from the substrate o-nitrophenil-Î²-D-galactopiranoside, whilst the specific activity was indicated by activity per unit of proteins. The result showed that both fungi could produce Î²-galactosidase. However, the enzyme activity did not increase significantly at various production times of 2, 4, 6, 8, and 10 days. The highest enzyme activity of LBKURCC67 and LBKURCC69 were 0.163 Â± 0.064 U/mL (at day 8) and 0.126 Â± 0.039 U/mL (at day 2) respectively. LBKURCC69 showed higher specific Î²-galactosidase activity (1.886 Â± 0.277 U/mg) than LBKURCC67 (1.179 Â± 0.081 U/mg).

Keywords: ÃŸ-galactosidase, dahlia tuber, endophytic fungi, Fusarium, ITS-rDNAÂ
Karangwangi peopleâ€™s local knowledge of bamboo and its role: Implications for management of cultural keystone species
Authors: PARTASASMITA RUHYAT , ANâ€™AMILLAH AZIFAH , ISKANDAR JOHAN , MUTAQIN ASEP ZAINAL , ANNISA ANNISA , RATNINGSIH NINING
Published: January 2017

Abstract. Partasasmita R, Anâ€™amillah A, Iskandar J, Mutaqin AZ, Annisa. 2017. Traditional knowledge of bamboo and its role in Karangwangi Village Cianjur, West Java: Implications for management of cultural keystone species. Biodiversitas 18: 275-282. Indonesia has a high diversity of bamboo, with more than 160 species can be found around the country. Nowadays, this plant is rarely planted around rural communities of West Java due to land use conversions and economic reasons. This research is to discuss traditional knowledge of local people of Karangwangi Village, Cianjur, West Java, Indonesia on diversity of bamboo and its role. The qualitative method was used in this study, while the data collection techniques, namely semi structure interview or deep interview and observation participant are applied. The result of study shows that based on the traditional knowledge of Karangwangi people, it has been reviled 13 species of bamboo, e.g., Bambusa blumeana J.A. & J.H. Schultz, Bambusa glaucophylla Widjaja, Bambusa maculata Widjaja, Bambusa vulgaris Schrad. Ex. Wndl. var vulgaris, Bambusa vulgaris Schrad. Ex. Wndl. var. striata, Gigantochloa apus J.A. & J.H. Schultz. Kurz., Gigantochloa atrovilacea Widjaja, Gigantochloa atter (Hassk.) Kurz., Gigantochloa hasskarliana (Kurz.) Backer ex Heyne, Gigantochloa pseudoarundinacea (Steud.) Widjaja, Schizostachyum iraten Widjaja, Schizostachyum sp., and Dinochloa scandens (Blume ex Neese) Kuntze. On the basis of deep interview, these bamboo species have traditionally various used, such as building materials, furnitures, household appliances, working tools, medicine, consumption, traditional musical instruments, traditional game, and decoration. In addition, Bamboo soften feature prominently in the language, ceremonies, and narratives of native peoples, so it can be considered as a cultural icons. The implications of these discussion are with respect to conservation as cultural keystone species.

Keywords: Bamboo, biodiversity, cultural keystone species, ethnobiology, Karangwangi
On the reduced Redlich-Kister excess properties for 1,2-dimethoxyethane with propylene carbonate binary mixtures at temperatures (from 298.15 to 318.15) K.
Authors: Salhi Hanen , Babu Shaik , Al-Eidan Nada , Mekni Nejib H. , Al-Otaibi Noura Omar , Alqahtani Khadija Y. , Al-Omair Nuhed A. , Ouerfelli Noureddine
Published: January 2017

Values of excess properties in 1,2-dimethoxyethane + propylene carbonate binary liquid mixtures at different temperatures from experimental density and viscosity values presented in earlier work, were used to test the applicability of the correlative reduced Redlich-Kister functions and the Belda equation, and to reveal eventual specific interaction hidden by the classical treatment of direct excess Redlich-Kister functions. Their correlation ability at different temperatures, and the use of different numbers of parameters, is discussed for the case of limited experimental data. The relative Redlich-Kister functions are important to reduce the effect of temperature and, consequently, to reveal the effects of different types of interactions. Values of limiting excess partial molar volume at infinite dilution deduced from different methods were discussed. Also, the activation parameters and partial molar Gibbs free energy of activation of viscous flow against compositions were investigated. Correlation between the two Arrhenius parameters of viscosity shows the existence of main different behaviors separated by a stabilized structure in a short range of mole fraction in 1,2-dimethoxyethane (0.45 to 0.83). In this context, the correlation Belda equation has also been applied to the present system for thermodynamic properties in order to reveal eventual solute-solvent interaction at high dilution.
Noise Stress Induces an Epidermal Growth Factor Receptor/Xeroderma Pigmentosum–A Response in the Auditory Nerve
Authors: Guthrie O’neil W.
Published: January 2017

In response to toxic stressors, cancer cells defend themselves by mobilizing one or more epidermal growth factor receptor (EGFR) cascades that employ xeroderma pigmentosum–A (XPA) to repair damaged genes. Recent experiments discovered that neurons within the auditory nerve exhibit basal levels of EGFR+XPA co-expression. This finding implied that auditory neurons in particular or neurons in general have the capacity to mobilize an EGFR+XPA defense. Therefore, the current study tested the hypothesis that noise stress would alter the expression pattern of EGFR/XPA within the auditory nerve. Design-based stereology was used to quantify the proportion of neurons that expressed EGFR, XPA, and EGFR+XPA with and without noise stress. The results revealed an intricate neuronal response that is suggestive of alterations to both co-expression and individual expression of EGFR and XPA. In both the apical and middle cochlear coils, the noise stress depleted EGFR+XPA expression. Furthermore, there was a reduction in the proportion of neurons that expressed XPA-alone in the middle coils. However, the noise stress caused a significant increase in the proportion of neurons that expressed EGFR-alone in the middle coils. The basal cochlear coils failed to mobilize a significant response to the noise stress. These results suggest that EGFR and XPA might be part of the molecular defense repertoire of the auditory nerve.
Pola Sensitifitas Bakteri dan Penggunaan Antibiotik
Authors: Katarnida Sri Sulastri , Karyanti Mulya Rahma , Oman Dewi Murniati , Katar Yusticia
Published: January 2017

Latar belakang.Penggunaan antibiotik yang tidak tepat bisa mengakibatkan resistensi obat, meningkatkan morbiditas, mortalitas dan biaya pengobatan. Faktor utama menentukan tepatnya penggunaan antibiotik adalah pemilihan antibiotik yang tepat, berdasarkan bakteri penyebab dan sensitifitasnya terhadap antibiotik. Sampai saat ini penelitian penggunaan antibiotik dan pola sensitifitas bakteri pada pasien anak di RS Penyakit Infeksi Sulianti Saroso belum pernah dilakukan.Tujuan. Mengetahui pola bakteri dan sensitifitasnya terhadap antibiotik pada pasien anak yang dirawat di RSPI SS.Metode. Penelitian dilakukan secara deskriptif, retrospektif dari rekam medis pasien rawat inap anak nonbedah, umur 1 bulan-15 tahun, dan hasil kultur tumbuh bakteri, periode tahun 2010 dan 2011. Pasien PICU dan pasien yang dalam perawatannya didiagnosis sebagai pasien bedah dikeluarkan dari penelitian.Hasil. Kultur dilakukan pada 286/1256 (22,8%) sampel, tumbuh bakteri pada 96/286(33,6%). Kelompok bayi 1bulan-<1tahun 14 (26,9%) paling banyak dilakukan kultur. Hasil kultur terbanyak S. typhi11/54 (20,4%), E. coli9/54 (16,7%) dan S epidermidis 7 (13%). S. typhisensitif 100% terhadap sefotaksim, seftriakson, kloramfenikol, dan kotrimoksazol. SensitifitasE. coli62,5% terhadap kloramfenikol, tetapi kurang sensitif terhadap antibiotik lainnya.Kesimpulan. Bakteri terbanyak ditemukan S typhi (20.4%)danE coli (16.7%). Sensitifitas S typhi 100% terhadap semua antibiotik yang digunakan (kotrimoksazol, tiamfenikol, kloramfenikol, sefotaksim dan seftriakson). Penggunaan antibiotik untuk S typhimasih bisa dengan lini pertama antibiotik sejauh tidak ada kontra indikasinya.
APLICATIVO PARA USO DE ARCGIS 10 NA ANÁLISE E INTEGRAÇÃO DE DADOS ESPACIAIS PARA GERENCIAMENTO DE ÁREAS CONTAMINADAS
Authors: Squissato Bianca Vazzoler Alves de Oliveira , Kiang Chang Hung
Published: January 2017

Esta pesquisa trata do uso de sistemas de informações geográficas no gerenciamento de áreas contaminadas, com ênfase na avaliação de risco à saúde humana. Neste estudo foi desenvolvido um aplicativo em ambiente ArcGIS Desktop 10.0®, com os objetivos de integrar informações geoambientais de uma área, em um único banco de dados, e quantificar o risco à saúde humana em função da presença de contaminantes nesse local. Para essas finalidades, a modelagem do banco de dados e posterior criação foram realizadas utilizando ArcCatalog, o qual possibilitou o cadastro de informações tais como: caracterização dos contaminantes, dos meios afetados e do transporte, dados associados aos receptores e às vias de exposição. O aplicativo de avaliação de risco à saúde humana, denominado de RISCO-CETESB, baseou-se nas Planilhas de Avaliação de Risco da CETESB, assumindo como valores de referência, alerta e intervenção os Valores Orientadores para Solos e Águas Subterrâneas do Estado de São Paulo, estabelecidos pela CETESB. O aplicativo constitui uma importante ferramenta na etapa de análise de risco do gerenciamento de áreas contaminadas, uma vez que permite maior agilidade na manipulação dos resultados. Além disso, o aplicativo gera relatório com os resultados obtidos na simulação, além de destacar espacialmente se uma área de estudo possui risco aceitável ou não.
MUTAGENESIS IN Tradescantia pallida AS A BIOMARKER OF THE EFFECTS OF WATER POLLUTED WITH URBAN EFFLUENT
Authors: Araújo Ana Lúzia de Souza , Guimarães Eliane Tigre , Seriani Robson
Published: January 2017

The present paper evaluated the toxicity of effluent released into the Tiete River, in Barra Bonita City, São Paulo State, using the test micronucleus with Tradescantia pallida. Young inflorescences of T. pallida (n = 20) were partially immersed in one of three treatments: water containing effluent, a positive control (0.1% formaldehyde), and a negative control (distilled water). The results showed a statistically significant difference (p < 0.05) between groups, indicating the genotoxicity of the effluent.
AVALIAÇÃO DAS CONDIÇÕES SOCIOECONÔMICAS E AMBIENTAIS DE PROPRIEDADES AGRÍCOLAS DO MUNICÍPIO DE ILHA SOLTEIRA - SÃO PAULO, BRASIL
Authors: Martins Mauro , Américo Juliana Heloisa Pinê , Carvalho Sérgio Luís de , Freitas-Lima Elizete Aparecida Checon de
Published: January 2017

O objetivo do trabalho foi avaliar as condições socioeconômicas e os problemas ambientais em propriedade rurais do município de Ilha Solteira, Estado de São Paulo e verificar como esses problemas são tratados de acordo com o grau de conscientização dos produtores. Foram visitadas 50 propriedades rurais, onde se aplicou um questionário envolvendo aspectos sociais, econômicos e os principais problemas de degradação ambiental. Abordaram-se aspectos relacionados ao uso e conservação do solo, disposição de resíduos sólidos e líquidos, descarte das embalagens de agrotóxicos, uso de equipamentos de proteção individual e lançamento de esgotos nas propriedades, entre outras ocorrências, procurando-se também avaliar a importância que os produtores e agregados atribuem aos recursos naturais e ao meio ambiente. Foram identificados diversos processos de degradação ambiental traduzidos por problemas de erosão, principalmente nas grandes propriedades, formas inadequadas de disposição dos resíduos sólidos, inadequação no descarte de embalagens de agrotóxicos falta do uso de equipamentos de proteção individual em algumas propriedades e pelo lançamento de grande parte dos esgotos em fossas negras.
VALORAÇÃO DO RECURSO “ÁGUA” A PARTIR DA DISPOSIÇÃO A PAGAR DOS USUÁRIOS: ESTUDO APLICADO NAS ÁREAS ATENDIDAS PELA COSANPA NA REGIÃO METROPOLITANA DE BELÉM
Authors: Borges Novaes Verena Gonzaga , Da Silva Ismael Matos
Published: January 2017

Apesar de possuir água em abundância, a região amazônica sofre com a falta de qualidade do recurso hídrico. Dentre as causas desse problema, destaca-se o lançamento indevido de esgoto in natura nos rios amazônicos. Na Região Metropolitana de Belém (RMB), do total de esgoto residencial produzido, menos de 2% são tratados. Além da falta de tratamento, há também o desperdício, que se relaciona diretamente com a quantidade de efluente produzido. Atualmente, o preço mínimo cobrado pela companhia de saneamento e abastecimento de água (COSANPA) por m3 de água é de R$1,40, valor que envolve somente os custos de distribuição e tratamento da água, desconsiderando-a como bem econômico. Com vistas a essa situação, o presente trabalho propõe uma metodologia para estipular a cobrança do valor econômico da água e propiciar fundos para a reestruturação do sistema de abastecimento de água, bem como a expansão do sistema de coleta de esgoto da COSANPA. A pesquisa adota como objeto de estudo as áreas residenciais da RMB que são abastecidas pela COSANPA. A metodologia escolhida é o Método de Valoração Contingente, a partir da Disposição a Pagar (DAP) da população amostrada. A análise dos dados realiza-se por regressão linear, pelo método dos Mínimos Quadrados Ordinários. A DAP média estimada foi de R$ 2,22, resultando na arrecadação anual de cerca de R$40 milhões, que poderão ser usados para efetivar melhorias técnicas no sistema de abastecimento e proporcionar a expansão do sistema de coleta e tratamento de efluentes.
DISTRIBUIÇÃO ESPACIAL E TEMPORAL DE UMA COMUNIDADE DE ANFÍBIOS ANUROS DO MUNICÍPIO DE RIO CLARO, SÃO PAULO, BRASIL
Authors: Toledo Luis Felipe , Zina Juliana , Haddad Celio Fernando Baptista
Published: January 2017

A compreensão da composição e inter-relações das comunidades faunísticas são fundamentais para a execução de medidas conservacionistas em ambientes florestais.

No presente estudo nos avaliamos a comunidade de anfíbios de uma floresta estadual no município de Rio Claro, SP, com enfoque na biologia reprodutiva. Foram registradas 21

espécies, de quarto famílias: Bufonidae, Hylidae, Leptodactylidae e Microhylidae. As espécies da família Bufonidae reproduziram durante a estação fria e seca do ano e as demais somente durante a estação quente e chuvosa. Além de segregação temporal, algumas espécies dividiram o ambiente físico durante o período reprodutivo. Acentuada

sobreposição temporal e espacial foi observada entre espécies filogeneticamente próximas, como entre Hyla nana e H. sanborni, entre Scinax fuscovarius e Scinax sp.

(aff. similis), e entre Leptodactylus fuscus, L. mystacinus, e Leptodactylus sp. (gr. fuscus). Nestes casos, diferenças acústicas podem ter sido o principal fator responsável pela

segregação reprodutiva. Ausência de segregação reprodutiva foi observada entre espécies do gênero Bufo, as quais foram vistas em amplexo interespecífico, apesar das diferenças

acústicas entre seus cantos de anúncio.
CARACTERIZAÇÃO FÍSICA E SÓCIO-AMBIENTAL DA ATIVIDADE DE PISCICULTURA: CASO DA BACIA HIDROGRÁFICA DO RIO CUBATÃO DO NORTE – SC - BRASIL
Authors: Aquino Paula Queiroz , Gonçalves Monica Lopes
Published: January 2017

Este trabalho objetiva avaliar os impactos sócio-econômicos e ambientais causados pela piscicultura na Bacia Hidrográfica do Rio Cubatão do Norte (BHRCN), localizada na região Norte do Estado de Santa Catarina. O trabalho de campo foi realizado através de visitas aos locais onde a piscicultura é praticada, sendo avaliada a existência de licenças ambientais e projetos de construção dos tanques, o tipo de solo onde são encontradas as instalações, o ganho econômico da atividade, identificação dos peixes criados na região e outros, através da aplicação de um questionário durante o primeiro semestre de 2005. Os resultados foram obtidos em 19 das 26 propriedades visitadas com tanques de peixe na área da BHRCN. No que diz respeito à obtenção de licença ambiental, 68,4% dos entrevistados afirmaram não ter ou não saber de sua existência, assim como 63,16% não tiveram ou não sabem da existência do projeto de construção dos seus tanques, o que pode implicar em severos impactos ambientais na região. Observou-se que 42,1% das propriedades apresentam solo pedregoso, que é inadequado à implantação de tanques de peixe, uma vez que este facilita a infiltração da água no solo. Percebeu-se que 47,4% dos tanques de peixes foram construídos para consumo na propriedade, sem interesse comercial pela atividade. Diversos tipos de peixes foram encontrados nas propriedades, tais como tilápia (Oreochromis spp), carpa (Cyprinus spp), traíra (Hoplias malabaricus) e pacu (Piaractus mesopotamicus). A partir dos resultados conclui-se que a falta de regulamentação dos tanques e a carência de informação por parte dos piscicultores podem gerar impactos nas águas superficiais e subterrâneas da região.
Das Konzept ,,Reallabor” schärfen: Ein Zwischenruf des Reallabor 131: KIT findet Stadt
Authors: Parodi Oliver , Albiez Marius , Beecroft Richard , Meyer-Soylu Sarah , Quint Alexandra , Seebacher Andreas , Trenks Helena , Waitz Colette
Published: January 2017

Gemeinsam mit der Bürgerschaft gestaltet das Reallabor 131 : KIT findet Stadt das Leben in der Karlsruher Oststadt nachhaltiger. Das Team will auch den neuen Forschungsansatz Reallabor voranbringen und hat aus den ersten Ergebnissen essen-zielle Kriterien für die Etablierung
von Reallaboren entwickelt.
Checklist of Mosses (Bryophyta) of Bodamalai Hills in Eastern Ghats, Tamil Nadu
Authors: Palani R , Sathish S Sahaya , Thamizharasi T , Vijayakanth P
Published: January 2017

Bodamalai Hills, situated on the Southern Eastern Ghats of Tamil Nadu, were explored for mosses (bryophyta) for the first time. As a result a checklist of mosses has been prepared comprising 52 species belonging to 38 genera and 21 families. The dominant families with the maximum number of species are Pottiaceae, Bryaceae, Stereophyllaceae, Sematophyllaceae and Brachytheciaceae. The dominant genera are Brachymenium and Bryum and the dominant species are Barbula javanica and Bryum capillare.