bluuebunny/crossref_metadata_2025 huggingface dataset:
A Case Study Highlighting the Impact of Dadhimadi Ghrut on Pandu Roga w.s.r. to Iron Deficiency Anemia
Authors: Aishwarya Pandey  , Ashok Kumar Sharma
Published: November 2024

Context: In India, the most common cause of anemia is a nutritional iron deficiency. The nearby term for iron deficiency anemia (IDA) in Ayurveda is Pandu Roga. Due to the high prevalence of IDA in society and the frequent side effects of oral allopathic iron preparations, Ayurvedic ghee was given in a case report of a woman suffering from IDA in order to evaluate the efficacy of Dadhimadhi Ghrut, an Ayurvedic remedy. Aim: Evaluation of role of Dadhimadhi Ghrut in haemoglobin level and iron binding capacity in a patient suffering from Pandu (IDA). Design: Case report - Clinical study. Materials and Methods: The study was conducted on a woman of IDA for a period of 12 weeks. Clinical features and hematological parameters were documented before, during and after treatment. Results: The present study shows that the trial drug Dadhimadhi Ghrut is effective to improve clinical features and hematological parameters significantly. The medicine is effective to increase the hemoglobin level g/dL (8.4 -10.1g/dL) in 6 weeks and 3.61g/dL (8.4 -12.01g/dL) in 15 weeks. No adverse effect of the trial drug was observed during the study. Conclusion: The results suggest that Dadhimadhi Ghrut is significantly effective in the management of IDA in anemic woman.
Management of Grade III Internal Hemorrhoids by HAL (Haemrriodal Artery Ligation) and Tikshna Kshara Application
Authors: Mohd Zahoor Bhat  , Karthik NM  , L. Manonmani  , Lavesh Jangamashetti
Published: November 2024

This study aims to standardize a hybrid procedure to be used in internal Hemorrhoids (Arsha) without complication of post-operative bleeding and severe pain experienced by patients in other forms of surgical interventions. Methodology: A patient diagnosed with Grade III hemorrhoids visited outpatient department and after thorough discussion, evaluation and physical/local examination was advised to undergo Tikshana Kshara therapy along with HAL for redressal of symptoms presented as bleeding per rectum. The patient was sent for routine pre surgical investigations and pre-anesthetic checkup. A surgical plan was devised for the case using Vicryl 2-0 for HAL and Tikshana Apamarga Kshara for application on pile mass. A half slit proctoscope was used for visualization of each pile mass. Suture of 8 shape was taken at the base of each pile mass for ligation with Vicryl 2-0 and Tikshana Kshara was applied after that on each pile mass for 40 sec one after the another. Khasra was washed with Nimbu Swaras to prevent Atidagdta by Kshara. There was minimal bleeding at the time of suturing and colour of the pile masses changed immediately to Pakva Jamunphala varna. A standard Kshara prepared using Apamarga, Suddha Varga and Chitraka was used for application. Patient was kept under observation for post-operative care. Efficacy was assessed after 15 days of the procedure. Results: The procedure produced encouraging results with significant reduction in size pile masses. There was no post-operative pain or constipation. There was minimum to no post-operative bleeding or stenosis. Conclusion: This hybrid combination by usage of Vicryl 2-0 and Tikshana Kshara application shows promising results in management of G-III hemorrhoids with no to minimal complication and post-operative care. Patient can immediately get back to work with some precautions.
An Insight into the Management of Amavata in Ayurveda
Authors: Surabhi G B  , Sowmyashree U P  , Gopala Krishna G
Published: November 2024

Acharya Madhavakara first identified Amavata as a separate disease in the Madhavanidana. Amavata manifests due to the consumption of Nidanas i.e., Viruddha Ahara-chesta, Mandagni, Nischalatha and immediate Vyayama after consuming Snigdha Bhojana. These factors resulting in Mandagni, which is a primary cause of Ama formation. This morbid Ama then circulates throughout the body with the vitiated Vata dosha. Ama eventually accumulates in the Sleshma sthana, results in joint pain, stiffness and ultimately causes Amavata. Comparable to rheumatoid arthritis due to similar symptoms. Rheumatoid arthritis is a chronic inflammatory disease causing symmetric peripheral polyarthritis and joint damage. Affecting 0.8-1.0% of the Indian population, rheumatoid arthritis predominantly impacts females than males. A 23-year-old female patient was admitted with the chief complaint of pain in multiple joints for 5 years. This was associated with stiffness, swelling, loss of appetite, fatigue, hard stools and a feeling of heaviness in the body. Rheumatoid arthritis is managed by DMARDs and steroids but it has adverse effects of gastritis and peptic ulcer disease as well as renal function impairment. In Ayurveda details description of management of Amavata is mentioned. Considering the signs and symptoms, the patient was treated according to the treatment principles of Amavata. Langhana, Deepana-Pachana, Valuka Sweda, Anulomana, Vaitarana Basti were administered for 25 days and oral medications for 60 days. Before starting the treatment, grading was performed based on subjective and objective criteria. After treatment, the grade was reduced. Marked improvement was observed after the treatment, which also improved the quality of life.
To Evaluate Combined Efficacy of Amrutadya Guggulu and Udvartana followed by Bashpa Sweda in the Management of Sthaulya
Authors: Santosh I. Swami  , Payal Vilas Chavat
Published: November 2024

Obesity (Sthaulya) is increasing at an alarming rate in developed industrialized countries which are undergoing rapid nutrition and lifestyle disorders like Diabetes mellitus (T2DM), Coronary Heart Disease (CHD), hypertension. In Ayurveda, Sthaulya (obesity) is regarded as Medoroga, a disorder of Meda Dhatu which includes fat tissue and fat metabolism. In Ayurveda Sthaulya is regarded as Medoroga. In Sthaulya Meda causes obstruction all Strotasa which leads to of Koshthasthit Saman Vayu Vriddhi, which in turn causes Jatharagnivardhana. It leads to Medadhatvagni Mandya and augmentation of Meda which results in Chalaspika, Chalaudara, Chala stana. According to WHO World Health Statistics Report 2012, globally one in 6 adults are obese and nearly 2.8 million individuals die each year due to overweight. Amrutadya Guggulu shows Rasa-Katu, Tikta, Kashaya, Guna-Laghu, Ruksha and Virya-Ushna, Vipaka-Katu, Dosha, Karma-Kapha Vatashamaka is effective in the management of Sthaulya. The ingredients of Udvartana Triphala (Kaphahara, Deepan), Musta, Darvi, Devdaru are Tikta, Kashay, Laghu, Ruksha Gunatamak having Sthaulyahara property. Bashpa Sweda given after Udvartana will make Vilayana of Vikruta meda. Due to this property, it breaks the Samprapti of Sthaulya. Hence the present attempt is done to encompass the upto date comprehensive literature to study the mode of action of Amrutadya Guggulu and Udvartna followed by Bashpa Sweda in the management of Sthaulya w.s.r. to Ayurvedic properties. Total 40 patients were enrolled in this study, significant result was seen in all subjective criteria, also 4 to 4.5kg weight loss is seen in all patients. For statistical analysis paired student ‘t’ test, Wilcoxon test were used.
Review on Cultivation Practices of Haridra (Curcuma Longa Linn.)
Authors: Pratima Dolase  , Vivek Chaudhari
Published: November 2024

Haridra, scientifically known as Curcuma longa Linn, is a significant spice and medicinal plant valued for its rhizomes, particularly for their active compound, curcumin. This article explores the cultivation practices of Haridra, emphasizing essential aspects such as soil and climate requirements, propagation methods, irrigation, pest and disease management, and post-harvest techniques. Turmeric thrives in well-drained, loamy soils with a pH between 5.0 to 7.5, and requires a warm, humid climate for optimal growth. Propagation primarily occurs through healthy rhizomes, which are planted at specific depths and spacing to maximize yield. Effective irrigation practices, complemented by balanced fertilization and integrated pest management strategies, are crucial for healthy plant development. Post-harvest practices, including proper curing and drying, are essential for maintaining quality and marketability. By implementing these best practices, farmers can enhance productivity, ensuring the sustainability and economic viability of Haridra cultivation in the face of increasing global demand as a medicinal as well spice plant.
Peran Spiritualitas-Moralitas Pemimpin Dalam Kitab Hakim-Hakim 19:1-30
Authors: Sihura Selatieli
Published: November 2024

This article aims to discover the leadership ethics of Judges 19:1-30. This text is filled with edifying teachings about the importance of good ethics-morality of a spiritual leader. A servant of God in his ministry cannot act at will, he always holds the values that are inherent to him, namely the ethics of a servant of God. For a leader, ethics-morality is an important part for him to carry out the duties of his calling. The book of Judges 19:1-30 shows how the ethics of a servant of God did not work properly, marked by the horrific moral decline of the Israelites at that time. This book contains educational teaching. The research method used qualitative research methods including narrative analysis and theological reflection of Judges 19:1-30 with the character of a Levite. The research intends to develop an ethic of leadership that is obedient and in accordance with God's will. The results of this study show that Judges 19:1-30 is a teaching of God's truth actualized through the life of a spiritual leader who lives in righteousness, holiness of self, high ethics and morality.
Penggunaan Metode Pembelajaran Problem SolvingSebagai Strategi Pendidikan Agama KristenDalam Peningkatan Karakter Siswa Kristen
Authors: Tarore Debby Margaret
Published: November 2024

Abstract: This study aims to determine the results of using problem solving learning methods in an effort to improve the character of SMK students. The method used in this study is qualitative and this research was carried out at the Christian Christian Vocational School of Saws, Semarang. Data were obtained through student attitude assessment tables and research instrument tables. Education plays a very important role in improving human resources. In essence, education aims to shape the character of someone who believes and fears God. Christian Religious Education is a vehicle for learning that facilitates students to know God through His works and to realize their knowledge of the Triune God through an attitude of life that refers to Christian values. The main task of a teacher is to be responsible for helping students in terms of learning, including in character education. In the teaching and learning process, it is the teacher who conveys the lesson, solves problems that occur in class, makes evaluations of student learning, both before, during and after the lesson takes place. The problem to be studied in this paper is whether problem solving learning methods can help improve student character according to the purpose of this writing. The conclusion of this paper is learning by using.
Pendekatan Reward Dan Punishment Dalam Pembelajaran Pendidikan Agama Kristen Untuk Meningkatkan Motivasi Belajar Siswa
Authors: Tefbana Abraham , Sanjaya Agus
Published: November 2024

Abstract: The purpose of this study was to determine the relationship between giving reward and punishment with increasing student motivation in learning Christian Religion Education. This research is based on Skinner's theory of operant conditioning (responsive behavior habituation). This study uses a qualitative descriptive method approach to explain the impact of reward and punishment as a strategy to increase student motivation in learning Christian Religious Education. Giving reward and punishment is a teacher's response behavior to increase student motivation in Christian Religious Education subjects. The results of this study indicate that giving rewards to outstanding students and punishing students who are not disciplined in learning, has a positive impact on increasing student motivation in learning Christian Religion Education.
Pendidikan Agama Kristen Memerangi Kekerasan Seksual Terhadap Anak Dalam Keluarga
Authors: Lekahena Welly Sany
Published: November 2024

Abstract: Increasing news about child sexual abuse in the mass media has shocked many people. society is shocked. Cases of child sexual abuse within the family are still being reported. Children who are victims of sexual violence sexual violence in the family need to be protected and not victimized by parents, because sexual violence experienced by children will have an impact on their health. parents, because sexual violence experienced by children will have a negative impact on their growth and development, especially on their psychology and development. on their growth and development, especially on the psychology and mentality of the child. psychology and mentality of the children themselves. Children who are the next generation of the church and also the nation need to be educated and protected from an early age. Because if many children who feel and experience sexual violence, it is possible that the child will become a perpetrator of sexual violence in the days to come or in the future. perpetrators of sexual violence in the days to come or when they are adults. The purpose of this study is to provide an understanding of Christian religious education related to the responsibility of parents as representatives of related to the responsibility of parents as God's representatives in the family, not as perpetrators of sexual violence for children. family not as perpetrators of sexual violence for children. This research This research uses a literature study method in which the information or results summarized are obtained from various sources, namely the internet, television, journals and other sources. summarized from various sources, namely the internet, television, journals and other media. other media.
Dynamic response of carbohydrates and proteomic profile during the regeneration of adventitious shoots from in vitro culture of Passiflora cincinnata Mast. endosperms
Authors:   , Sarmento Suellen Nunes
Published: November 2024

Characteristics such as the totipotency of plant cells underpin in vitro culture techniques. Endosperm is a naturally triploid tissue resulting from the double fertilization process. In vitro culture of endosperms has shown potential as a direct method for the regeneration of triploid plants, offering a faster alternative for large-scale production of triploid plants. This study presents two chapters that aim to consolidate advancements in the field of in vitro triploid plant regeneration from endosperm and investigate structural and biochemical changes, identifying patterns in carbohydrate utilization and differential protein accumulation related to the regeneration process of Passiflora cincinnata Mast explants. Our goal is to enhance the understanding of the mechanisms involved in triploid plant regeneration and optimize in vitro endosperm culture protocols to support the use of this technique in genetic improvement studies. Keywords: endosperm, in vitro regeneration, triploidy.
NUROTA TOG‘ TIZMASINING TOSH DAVRI ARXEOLOGIYASINING O‘RGANILISH TARIXI
Authors: O‘ng‘alov Lazizbek
Published: November 2024

Zarafshon havzasi O‘zbekistoninng markazida joylashgan bo‘lib, bu muzofotda insoniyat madaniyat izlari paleolit davridan boshlab mavjud bo‘lgan. Bu hududda tashkil topgan madaniyat mahalliy negizda shakllanganligi tadqiqotlar tufayli o‘z isbotini topdi. Shuningdek, Nurota tog‘ tizmasining shimoliy qismi arxeologlar tomonidan keng ko‘lamda o‘rganilib kelinmoqda. Bu izlanishlar davomida mintaqa o‘rta asrlarda odamlar tomonidan intensiv o‘zlashtirilganligi oydinlashdi. Yaqin kunlargacha Nurota tog‘ tizmasining shimoliy qismida tosh davriga oid topilmalar qo‘lga kiritilgan emas edi.
QO’QON XONLARI SULOLASINING GENEOLOGIK TAHLILI
Authors: Esonov Ziyodbek
Published: November 2024

Mazkur maqolada Qo'qon xonlari sulolasining geneologik tahlili masalalari yortilgan. Asosiy e'tibor mazkur suloladagi xukmdorlarni shajaradagi xronologik davri, suloladagi o'rni, uni boshqaruvi davridagi tarixiy jarayonlarni ko'rsatib berishga qaratilgan. Sulola geneologiyasi tadqiqi xonlik tarixini yanada kengroq o'rganilishidagi o'rni to'g'risida fikr mulohazalar bildrilgan.
O‘ZBEKISTON VA ITALIYA MUNOSABATLARINING ME’YORIY-HUQUQIY MANBALARI
Authors: Saidova Raxima
Published: November 2024

Mazkur maqolada 1991 yilda davlat mustaqilligi qayta tiklangan O‘zbekiston Respublikasi tashqi siyosiy faoliyatining me’yoriy-huquqiy asoslari shakllanishi jarayonida G‘arb dunyosining iqtisodiy va madaniy jihatdan nufuzli davlatlaridan biri – Italiya Respublikasi bilan ikki tomonlama munosabatlarining o‘rnatilishi hamda uning rivojlanish bosqichlari xususida so‘z yuritilgan.
QOYATOSH SURATLARIDA IBTIDOIY DAVR IQTISODIY HAYOTINING AKS ETISHI
Authors: Mirsoatova Sayyora
Published: November 2024

Mazkur maqolada yurtimizdagi mavjud qoyatosh suratlari orasida eng qadimgilari bo‘lmish Sarmishsoy va Zarautsoy qoya toshlariga chizilgan ibtidoiy odamlarning mehnat faoliyati, ya’ni ovchilik, ibtidoiy e’tiqodlari va diniy qarashlari zamirida paydo bo‘lgan sodda va oddiy ko‘rinishlar bilan bog‘liq tasvirlar bayon qilingan.
ВЛИЯНИЕ ДЕНЕЖНОЙ ЭМИССИИ В 1918-1920 ГОДАХ НА СОЦИАЛЬНО-ЭКОНОМИЧЕСКУЮ ЖИЗНЬ НАРОДОВ ТАССР
Authors: Луҳмонов Шаҳзод
Published: November 2024

В данной статье рассматриваются этапы ликвидации местных денег, введенных на территории РСФСР в годы гражданской войны в связи с экономической оторванностью территории Туркестана от центра. Также представлены аналитические аспекты реализации валют, выпущенных центральным правительством РСФСР в Туркестане, их различия по годам, девальвации и нестабильности денег из-за созданных проектов. Кроме того, по всей стране выявилось расширение условий для создания НЭПа. Эта статья может служить дополнительным ресурсом к уже проведенным исследованиям.
SOVET HOKIMIYATI TOMONIDAN O‘ZBEKISTONDA QORAKO‘LCHILIKNI RIVOJLANTIRISH TADBIRLARI
Authors: Axmedov Bekzod
Published: November 2024

1925 yilda O‘zbekiston SSR tashkil topgandan so‘ng, respublikada iqtisodiy sohada Markazning manfaatlari ustunlikka chiqishi, respublika asosan qishloq xo‘jaligi mahsulotlari ishlab chiqarishga ixtisoslashgan bo‘lib, bu murakkab ijtimoiy-siyosiy jarayonlarga olib kelganligi ochib berilgan. Ayniqsa, 1924-1925 yillarda qorako‘l qo‘ylarining soni keskin kamayganligi, 1928-1931 yillarda davlat siyosatining to‘g‘ri tashkil etilishi, xorijiy bozorlarga chiqish uchun xalqaro auksionlarning o‘tkazilishi natijasida O‘zbekiston qorako‘l terilari yetishtiradigan asosiy mintaqa sifatida e’tiborga olinganligi arxiv materiallari yordamida ochib berilgan.
NAMANGAN VILOYATI ZIYORATGOHLARINING AHOLINING IJTIMOIY HAYOTIDAGI O‘RNI (UYCHI TUMANI DEVONA BUVA ZIYORATGOHI MISOLIDA)
Authors: Mamatov Jasurbek
Published: November 2024

Mazkur maqolada Namangan viloyatidagi ziyoratgohlarning tarixi hamda bugungi kundagi faoliyati to‘g‘risidagi ma’lumotlar tahlil qilindi. Tadqiqot natijasida ziyoratgoh va unga bo‘lgan munosabat hamda an’anaviy qadryatlarning anchayin o‘zgarib borayotganligi ko‘zga tashlandi. Shu nuqtai nazardan ushbu maqolada ziyoratgohlarning aholining ijtimoiy hayotida tutgan o‘rni, holati, ziyorat turizmi bo‘yicha fikr-mulohalar keltirilgan.
ДОГОВОРНО-ПРАВОВАЯ БАЗА СОТРУДНИЧЕСТВА РЕСПУБЛИКИ УЗБЕКИСТАН И ИРАНА В ГОДЫ НЕЗАВИСИМОСТИ
Authors: Ахроров Ботир
Published: November 2024

В статье рассматривается развитие договорно-правовой базы сотрудничества между Республикой Узбекистан и Исламской Республикой Иран в период после обретения независимости Узбекистаном. Анализируются основные соглашения и меморандумы, заключенные в различных сферах, включая экономику, культуру, транспорт и региональную безопасность. Особое внимание уделяется визитам на высшем уровне и их роли в укреплении двусторонних отношений.
«OLMALIQ KON-METALLURGIYA KOMBINATI» AJDA ISHLAB CHIQARILADIGAN MAHSULOTLARNING SANOAT KORXONALARIDA QOʻLLANISHI
Authors: Muxitdinova Kamola
Published: November 2024

Maqolada «Olmaliq kon-metallurgiya kombinati» AJda ishlab chiqariladigan mahsulotlar nomenklaturasi va ularning sanoat korxonalarida qoʻllanilishi haqida ma’lumotlar keltirilgan boʻlib, yirik sanoat korxonalari mahsulotlarining tarkbiy ulushi tahlil qilingan.
КИЧИК БИЗНЕС МОЛИЯВИЙ РЕСУРСЛАРИ САМАРАДОРЛИГИ ОМИЛЛАРИ ВА УЛАРНИНГ ЎЗИГА ХОС ХУСУСИЯТЛАРИ
Authors: Кетманов Авазбек
Published: November 2024

Ушбу мақолода кичик бизнес молиявий ресурслари самарадорлиги омиллари ва уларнинг ўзига хос хусусиятлари ёритилган. Шунингдек, молиявий стратегиялар, кичик бизнеснинг молиявий ресурсларни назарий асослари ёритилган.
BOZOR MEXANIZMLARI, TOVAR VA XIZMATLAR MARKETINGI TIZIMIDA NARXNI SHAKLLANTIRISH USULLARI
Authors: Bahriddinov Jahongirbek
Published: November 2024

Maqolada tovar va xizmatlar marketingi tizimida bozor mexanizmlari, narxlarni shakllantirish usullari hamda yengil sanoat tovarlari bozoridagi raqobatning tasnifi va uni shakllantiruvchi omillar yoritilgan.
O'ZBEKISTONDA XOTIN-QIZLAR TADBIRKORLIGINI QO'LLAB-QUVVATLASH VA RIVOJLANTIRISH
Authors: Mirzayeva Shirin
Published: November 2024

Ushbu maqolada O‘zbekistonda xizmat ko‘rsatish sohasida ayollar tadbirkorligini rivojlantirishning tashkiliy-iqtisodiy mexanizmlari ko‘rib chiqiladi. Ayollar rahbarligidagi tadbirkorlikni muvaffaqiyatli rivojlantirishga xizmat qilayotgan ta’lim dasturlari va moliyaviy ko‘makning o‘rni masalasiga alohida e’tibor qaratilmoqda. Tadbirkor ayollar duch kelayotgan asosiy muammo va to‘siqlar, jumladan, huquqiy va iqtisodiy to‘siqlar tahlil etilgan. Xizmat ko‘rsatish sohasida ayollarga tegishli bo‘lgan muvaffaqiyatli korxonalarga misollar keltirilib, tadbirkor ayollar soni ortib borayotgani sababli iqtisodiy ko‘rsatkichlardagi ijobiy o‘zgarishlar muhokama qilinmoqda. Olingan maʼlumotlar asosida ayollar tadbirkorligini qoʻllab-quvvatlash boʻyicha tashkiliy-iqtisodiy muhitni yaxshilash boʻyicha tavsiyalar taklif etilmoqda.
ВНЕДРЕНИЕ ИННОВАЦИОННЫХ МЕТОДОВ ДЛЯ ПОВЫШЕНИЯ ЭФФЕКТИВНОГО ИСПОЛЬЗОВАНИЯ ВОДНЫХ РЕСУРСОВ
Authors: Рахимов Бахромжон
Published: November 2024

В статье приводятся значимость глобальной проблемы сокращения водных ресурсов в стране. На основе анализа мирового опыта, посредством внедрения современных, инновационных, ресурсосберегающих технологий, предложены пути повышения эффективного использования водных ресурсов.
CHAKANA SAVDO KORXONALARIDA XIZMATLAR KOʻRSATISHNING XUSUSIYATLARI
Authors: Ibragimova Nilufar
Published: November 2024

Ushbu maqolada chakana savdo korxonalari xizmatlari kategoriyasini aniqlashtirish, xizmat sifatini baholashda foydalaniladigan ilmiy tadqiqotlarni takomillashtirish, chakana savdo xizmatlari sifatini baholash bo‘yicha  nazariy jihatdan yoritib berilgan.
SHIHOBIDDIN SUHRAVARDIY FALSAFIY QARASHLARIGA IJTIMOIY-SIYOSIY VAZIYATLARNING TA’SIRI
Authors: Murtozayev Shahobiddin
Published: November 2024

Ushbu maqolada Shihobiddin Suhravardiy dunyoqarashining shakllanishi va rivojlanishida o‘rta asr Islom dunyosidagi ijtimoiy-siyosiy vaziyatning ta’siri tahlil qilinib, uning falsafiy qarashlari hamda asarlari orqali jamiyatdagi adolat va ma’rifatning ahamiyatiga bergan ta’kidlari, o‘sha davrda hukm surgan siyosiy tuzumlar, diniy va ma’naviy muhit bilan uzviy bog‘liqligi o’rganilgan. Shuningdek, Suhravardiyning ijtimoiy muhit bilan aloqalari, uning hukmdorlar va olimlar bilan bo‘lgan munosabatlari xususida batafsil so‘z yuritilib, o‘sha davrning siyosiy beqarorligi, diniy ziddiyatlar va madaniy yangilanishlar Suhravardiy falsafasi va uning e’tiqodlariga qay darajada ta’sir ko‘rsatgani ko‘rib chiqilgan.
XVIII ASR OXIRI VA XIX ASR BOSHLARIDA BUXORO AMIRLIGIDA ILM-FAN VA MADANIY HAYOT RIVOJI
Authors: Saburov Jaloliddin
Published: November 2024

Mazkur maqolada Buxoro amirligi davrida ilm-fan va islom ilmlari rivoji unda Buxoro amirlarining faoliyatlari ijtimoiy ma’naviy muhit va davrning o‘ziga xos xususiyatlari tahlil etilgan. Xususan, amirlikda Qur’on, hadis, fiqh va tasavvuf ilmlarini o‘rganishga bo‘lgan rag‘bat kishilar ma’naviy hayotidagi o‘rni birlamchi manbalar asosida ochib berilgan. Shuningdek, Buxoroda shakllangan tasavvuf va tariqtlarning o’zaro vorisiylik, uzviyligi rivojlanishi masalalariga ham alohida e’tibor qaratilgan. Amirlik hududlarida o’sha davrda faoliyat ko’rsatgan tariqatlar yoki so’fiylik toiflarining ijtimoiu hayotdagi o’rni, ma’naviy muhitga ta’siri bilan bog’liq jihatlari ham yoritilgan. Buxoroda amal qilib kelgan tariqatlar ularning ma’naviy axloqiy tamoyillari jamiyat ma’naviy hayotida tutgan o’rni ham manbalar asosida tahlil e’tilgan. Amirlar amirzodalar va saroy ahlining tasavvuf va tariqatlarga munosabatlari ayniqsa, naqshbandiyaning bu davr uchun o’ziga xos ahmiyati ham keng ochib berilgan.
JAMIYAT BARQARORLIGIGA OID QARASHLARINING SHAKLLANISHI
Authors: Saidkulov Nuriddin
Published: November 2024

Ushbu maqolada ilm-fan taraqqiyotida barqarorlik, jamiyat barqarorligi nazariyasi bilan shug‘ullangan va ushbu tendensiyaga o‘ziga xos tarzda yondashadigan nazariyotchi olimlar faylasuflar, sotsiologlar, tarixchi va boshqalar insoniyatning mavjudligi va barqarorligi, sivilizatsiya va taraqqiyot muammosiga turli jihatdan yondashganlari haqida so’z boradi. Bundan tashqari maqolada olimlar tomonidan yer yuzida turli xil yo‘llar bilan vujudga kelgan mustaqil sivilizatsiyalarni turli metodologiyalar bilan talqin qilishga harakat qilishgani va barqarorlikni ta’minlash yo’llari va bosqichlari haqida fikr boradi.
YOSH AVLOD KAMOLOTI VA KELAJAGINI MUSTAXKAMLASHDA INSONIYLIK VA VATANPARVARLIK TAMOYILLARINING O'RNI MASALASI HAQIDA
Authors: Yuldashev Farrux
Published: November 2024

Maqolada insonparvarlik, vatanparvarlik, bag‘rikenglik g‘oyalarining jamiyatimizning yetakchi kuchi bo‘lgan yoshlarning odob-axloqi, madaniyati, insonparvarlik fazilatlarini rivojlantirishdagi o‘rni va o‘rni ko‘rib chiqiladi. Olim va mutafakkirlar ilmiy merosidan yoshlar hayotida keng foydalanish yuzasidan fikr-mulohazalar bildirilmoqda.
SAMARALI YONDASHUVLAR ORQALI IKKINCHI TILNI (SLA) O‘RGANISHDA PRAGMATIK KOMPETENTSIYANI OSHIRISH STRATEGIYALARI
Authors: Paluanova Xalifa
Published: November 2024

Ushbu maqolada ikkinchi tilni (SLA) o‘rganishda pragmatik kompetentsiyani oshirishning samarali strategiyalari ko‘rib chiqiladi. Asosiy yondashuvlar, jumladan, topshiriqlarga asoslangan ta’lim, aniq va yashirin o‘rganish, o‘quv jarayoniga sho‘ng‘ish, raqamli modellashtirish, ijtimoiy-madaniy o‘rganish va fikr-mulohaza mexanizmlari o‘quvchilarning muloqot qobiliyatiga ta’siri uchun baholanadi. Topilmalar shuni ko‘rsatadiki, aniq pragmatik ta’limni immersion, interaktiv va madaniy jihatdan sezgir amaliyotlar bilan birlashtirgan aralash ta’lim yondashuvi SLA-da optimal natijalarni beradi.
СЕМАНТИКА ГЛАГОЛОВ В «ДИВАНИ ЛУГАТ-ИТ ТУРК» МАХМУДА КАШГАРСКОГО
Authors: Равшанов Махмуд
Published: November 2024

Данная научная статья посвящена исследованию лексико-семантических групп глаголов, собранных в книге лексикографа и филолога Махмуда Кашгари «Диван лугат ат-турки». В частности анализируются ЛСГ глаголов движения, говорения, действия, состояния, мышления и качества, изображения и звукоподражания. Семантические особенности глаголов «Словаря» соотносятся с глаголами современного узбекского языка.
INGLIZ VA QORAQALPOQ TILLARIDA ANTROPOTSENTRISTIK MAQOLLARNING SEMANTIK KLASSIFIKATSIYASI
Authors: Bekbergenova Gulaim
Published: November 2024

Antropotsentrik maqollar - bu insonning xatti-harakati, xususiyatlari va tajribasiga qaratilgan iboralar yoki maqollar. Bu maqollarda ko'pincha madaniy qadriyatlar, e'tiqodlar va odamlarning o'zaro munosabatlari va jamiyatdagi rollari bilan bog'liq normalar aks etadi. Ular jamiyatda donolik, axloqiy saboqlar va ijtimoiy me'yorlarni etkazish uchun vosita bo'lib xizmat qiladi.
ЛИНГВИСТИЧЕСКАЯ ОБЪЕКТИВИЗАЦИЯ ФРЕЙМА «МАТЬ» И «ОТЕЦ» В РУССКОМ И УЗБЕКСКОМ ЯЗЫКАХ
Authors: Хакбердиева Сайёра
Published: November 2024

История фрейма «мать» и «отец» в современной науке – это история возникновения и развития идеи, которая постепенно с течением времени обогатилась рядом коннотаций современного мира. Настоящее исследование посвящено комплексному изучению фреймов «мать» и «отец» в его разнородных и структурно-семантических проявлениях в русском и узбекском языках.
IJTIMOIY-SIYOSIY ASAR TARJIMASINING O’ZIGA XOS XUSUSIYATLARI
Authors: Xolmirzayev Baxtiyor
Published: November 2024

Ushbu maqola mustaqillik yillarida o‘zbek tilida yaratilgan ijtimoiy-siyosiy asarlarning ingliz tiliga tarjimalari tahliliga bag‘ishlangan. Darhaqiqat, mustaqillikdan so‘ng o‘zbek tilida yozilgan asarlarni xorijiy tillarga bevosita tarjima qilish amaliyoti keng ommalashdi. Ushbu maqolada ijtimoiy-siyosiy asarlar tarjimasining o’ziga xos xususiyatlari masalasi misollar yordamida tahlil qilinadi. Maqolaning oxirida tarjimalarni tahlil qilish natijasida olingan xulosalar keltirilgan.
TERRY PRATCHETTNING "GOOD OMENS" ROMANINI TARJIMA QILISHDAGI QIYINCHILIKLAR
Authors: Gubaydullin Artur
Published: November 2024

Ushbu maqola T.Pratchett romanlarida mavjud komediya va matnlararo elementlarni ko‘rsatishda tarjimonlar oldida turgan murakkab vazifani o‘rganadi. Madaniy tafovutlar sharoitida haqiqiylikni saqlab qolish muammosini ta'kidlab, tadqiqot tarjimada reprezentativlikka erishish uchun strategik vosita sifatida madaniy moslashuvning rolini o'rganadi.
ИНГЛИЗ ВА РУС ТИЛЛАРИНИНГ ҲИССИЙ КУЧАЙТИРГИЧЛАРИ
Authors: Абдуллаева Севара
Published: November 2024

Тилда таркибни кучайтириш учун когнитив асосларнинг бошқа концепцияси таклиф. Тавсия етилган семантик турдаги интенсификаторларнинг ҳар бирининг марказида тилнинг сирт-концептуал даражасида турли йўллар билан намоён бўладиган "куч" нинг чуқур когнитив прототипини кўриш таклиф етилади.
ФУҚАРОЛАРНИНГ ЎЗИНИ ЎЗИ БОШҚАРИШ ОРГАНЛАРИ МАНСАБДОР ШАХСЛАРИНИНГ КОНСТИТУЦИЯВИЙ-ҲУҚУҚИЙ ЖАВОБГАРЛИГИ
Authors: Рузметов Хайрулла
Published: November 2024

Мақолада фуқароларнинг ўзини ўзи бошқариш органлари мансабдор шаҳсларини конституциявий жавобгарлигининг назарий жиҳатлари, конституциявий принципларнинг талаблари ва уларга ҳуқуқий тартибга солишнинг, ҳуқуқни қўллаш амалиётини, ташкилий-ҳуқуқий асосларни мослиги кўриб чиқилган ва мазкур жиҳатларни такомиллаштиришга оид таклифлар берилган.
ХОРИЖИЙ ДАВЛАТ СУДЛАРИНИНГ ҚАРОРЛАРИНИ ТАН ОЛИШ ВА ИЖРО ЭТИШДА ДАВЛАТ СУВEРEНИТEТИ МАСАЛАЛАРИ
Authors: Халиқулов Комолиддин
Published: November 2024

Ушбу мақолада хорижий давлат судларининг қарорларини тан олиш ва ижро этиш жараёнида давлат суверенитети масалалари кўриб чиқилади. Мақолада халқаро ҳуқуқ принциплари ва миллий қонунчилик таҳлил қилинади. Шунингдек, давлатларнинг суверен тенглиги принципи ҳамда хорижий суд қарорларини тан олиш ва ижро этиш ўртасидаги муносабатлар ўрганилади. Тадқиқот натижасида хорижий суд қарорларини тан олиш ва ижро этиш жараёнида давлат суверенитетини ҳимоя қилишнинг замонавий тенденциялари ва муаммолари аниқланди.
IJTIMOIY HAVF GURUHIGA KIRUVCHI YOSHLAR O‘RTASIDA HUQUQBUZARLIKLARGA QARSHI KURASHISH BO'YICHA XORIJIY TAJRIBA
Authors: Djumaniyazova Dilfuza , Shayakubov Shomansur
Published: November 2024

Ushbu maqolada ijtimoiy havf guruhiga kiruvchi yoshlar tushunchasi va uning mazmuni haqida ma'lumotlar berilgan bo‘lib, uyushmagan yoshlar atamasining kelib chiqishi, ijtimoiy havf guruhiga kiruvchi va uyushmagan yoshlarni har tomonlama qo‘llab-quvatlash, ularni ijtimoiy hayotga tortish, orzularini ro‘yobga chiqarish va kelajagi uchun respublikamizda va xorijda amalga oshirilayotgan ishlar bayon etilgan.
КРИМИНОЛОГИЧЕСКИЕ (СОЦИАЛЬНЫЕ) ПРЕДПОСЫЛКИ И КОРНИ РАСПРОСТРАНЕНИЯ АЗАРТНЫХ ИГР СРЕДИ НАСЕЛЕНИЯ
Authors: Алиев Асилбек
Published: November 2024

В статье рассматриваются социальные причины и предпосылки участия населения в азартных и других основанных на риске играх. Исследуются предпринимаемые меры профилактики незаконной игорной деятельности и казино (притонов), делаются соответствующие выводы.
РЕГУЛИРОВАНИЕ ФИНТЕХА И КРИПТОВАЛЮТ: ОСНОВНЫЕ ВЫЗОВЫ И ПРАВОВЫЕ АСПЕКТЫ
Authors: Абдурахманова Нодирахон
Published: November 2024

Статья посвящена правовым вызовам, связанным с регулированием финтеха и криптовалют. Рассматриваются основные проблемы, такие как отсутствие унифицированной нормативной базы, трудности правовой квалификации криптовалют, защита прав потребителей, противодействие отмыванию денег и финансированию терроризма, налогообложение, кибербезопасность и защита от мошенничества. Приводятся примеры из международной практики и нормативные акты Узбекистана, которые регулируют данные вопросы. В статье подчеркивается необходимость разработки гибких и адаптивных правовых механизмов, обеспечивающих баланс между стимулированием инноваций и защитой прав участников рынка.
ТAСВИРИЙ СAНЪAТ ФAНЛAРИНИ ЎҚИТИШДA ИЛҒOР ТAЪЛИМ ТЕХНOЛOГИЯСИДAН ФOЙДAЛAНИШ СAМAРAДOРЛИГИНИ OШИРИШ
Authors: Берикбaев Aлишер
Published: November 2024

Ушбу мaқoлaдa Тaсвирий сaнъaт фaнлaрини ўқитишдa илғoр тaълим    технoлoгиясидaн фoйдaлaниш сaмaрaдoрлигини oшириш oрқaли улaрдa кaсбий кoмпетенциялaрини иннoвaциoн тaълим технoлoгиялaри aсoсидa ривoжлaнтириш oрқaли,  бўлaжaк мутaхaссис ўқитувчилaрнинг кaсбий сифaт элементлaрини хaр тoмoнлaмa ривoжлaнтиришдa муaммoли тaълим технoлoгиясининг aсoси инсoннинг фикрлaши муaммoли вaзиятни ҳaл этишдaн бoшлaниши ҳaмдa унинг муaммoлaригa қaндaй  ечим қўллaш керaклиги  ёритиб ўтилгaн.
TALABALARNING TASVIRIY SAN’AT MASHG‘ULOTLARIDA IJODIY QOBILIYATINI SHAKLLANTIRISH TEXNOLOGIYASI
Authors: Yusupova Shoxista
Published: November 2024

Ushbu maqolada tasviriy san’atning inson hayotidagi o‘rni. Bugungi kunda ta’lim sohasida olib borilayotgan katta islohatlar va uning natijalari. Tasviriy san’at mashg‘ulotlar jarayonida talabalarda ijodiy qobiliyatning muhum ahamiyati va ijodiy jarayon talab qilinadigan masalalar. Ta’lim berishda o‘qituvchining dars mashg‘ulotlarida qo‘yilgan maqsadi va vazifalari haqida ma’lumotlar berilgan. Talabalarning faol ijod qilishda o‘qituvchining pedagogik texnologiyalari tajribalarni amaliyotga tatbig‘i, ijodiy qobiliyatni rivojlantirish kabi salbiy xolatlarni bartaraf etishning eng samarali yo‘llari haqida batafsil ko‘rsatilgan.
O‘QITUVCHILARNI UZLUKSIZ KASBIY RIVOJLANTIRISHGA KOGNITIV-FUNKSIONAL YONDASHUV
Authors: Ibragimov A’lamjon
Published: November 2024

Mazkur ilmiy maqola o‘qituvchilarni uzluksiz kasbiy rivojlantirish jarayoniga kognitiv-funksional yondashuvni o‘rganishga bag‘ishlangan. Ushbu yondashuv o‘qituvchilarning kasbiy kompetensiyalarini chuqurlashtirish va ularning pedagogik faoliyatida zarur bo‘lgan bilimlarni samarali qo‘llashga xizmat qiladigan kognitiv jarayonlarni rivojlantirishga yo‘naltirilgan. Kognitiv va funksional omillarni uyg‘unlashtirish orqali o‘qituvchilarning bilimlari va ko‘nikmalarini uzluksiz ravishda yangilab borish, ularning pedagogik faoliyatini zamonaviy talablarga moslashtirish muhim omil hisoblanadi. Tadqiqotda kognitiv-funksional yondashuvning nazariy asoslari tahlil qilinib, uning o‘qituvch kasbiy rivojlanishidagi roli keng ko‘lamda yoritilgan. Shuningdek, bu yondashuv orqali o‘qituvchilarning malakasini oshirish jarayonlari samaradorligini oshirishga qaratilgan tavsiyalar berilgan.
MILLIY IQTISODIYOT RIVOJLANISHINING SHARTI SIFATIDA TA’LIM, FAN VA BIZNESNING O‘ZARO ALOQALARI MAZMUNI
Authors: Xoliqov Nasriddin
Published: November 2024

Ushbu maqolada milliy iqtisodiyot rivojlanishining sharti sifatida ta’lim, fan va biznesning o‘zaro aloqalari, integratsiyalashgan ilmiy-ta’lim berish jamoalarining shakllantirilishi shuningdek, mintaqalararo muammolarni hali qilishga, ilmtalab mahsulotlarni yaratishga ko‘maklashda fanni va ilmni rivojlantirishning ahamiyati haqida mulohazalar yuritilgan.
ATROF- MUHITNING YUQORI HARORATIDA MUSHAK FAOLIYATI
Authors: Ernazarov G‘olibjon
Published: November 2024

Mazkur maqola atrof-muhitning yuqori harorati sharoitida mushak faoliyatiga ta’sir qiluvchi omillar va ularning fiziologik jarayonlarga ta’sirini о‘rganishga bag‘ishlanadi. Yuqori haroratda mushaklar faoliyatiga ta’sir etuvchi asosiy omillardan biri – termoregulyatsiya va energiya sarflanishidir. Tana haroratining oshib ketishi mushaklarda charchoqning tezroq paydo bо‘lishiga, ish qobiliyatining pasayishiga va mushaklar quvvatiga ta’sir kо‘rsatishi mumkin. Shuningdek, maqolada musbat va salbiy omillar hamda yuqori harorat sharoitida mushak faoliyatini yaxshilash yо‘llari tahlil qilingan.
Actual issues of justifying the size of the sanitary protection zone of an enterprise, taking into account odour in atmospheric air
Authors: Sabirova Zulfiya F. , Budarina Olga V.
Published: November 2024

Introduction. The basis for determining the size of the sanitary protection zone (SPZ) is the classification of potentially hazardous objects taking into account a specific industry. At the same time, emissions from a significant number of industries contain substances possessing of an odour. The smell can spread over significant distances, exceeding the SPZ size, being the cause of frequent complaints from the population. However, taking into account the odour when justifying the SPZ size remains an unresolved methodological, scientific, and legal problem.
The purpose of the study. Hazard assessment of enterprises (productions) taking into account the criterion of odour in the atmospheric air of populated areas with the development of methodological approaches to substantiate the size of the SPZ.
Materials and methods. A coffee production company was selected as a pilot facility. The design documentation of the development of maximum permissible emissions (MPE), justification of the SPZ size, protocols of ambient air pollution assessment has been studied. The risk assessment to public health has been carried out in accordance with Guidance 2.1.10.1920–04. Olfacto-odourimetric and chromatography-mass spectrometry studies of emissions and ambient air in the vicinity of enterprise have been conducted.
Results. For the production under consideration, taking into account the results of olfacto-odourimetric studies, the size of the SPZ, which provides comfortable living conditions (absence of offensive odour), is 700 m from the main source, i.e. 1.3–4.5 times higher than when justified by the traditional method.
Limitations are due to the lack of standards for a significant number of volatile organic compounds present in emissions from odorous industries.
Conclusion. Methodological approaches to substantiating the hazard class and SPZ size taking into account the odour are proposed on the example of coffee production. The developed algorithm can be applied to assess the danger of various enterprises and industries whose emissions contain odorous substances.
Hygienic control and assessment of the risk of contamination of the indoor environment with microscopic fungi
Authors: Kalinina Natalia V. , Slobodyan Vladimir G. , Starodubova Natalya Yu. , Gaponova Elena B. , Banin Ilya M.
Published: November 2024

Introduction. The article provides a rationale for the methods of detection, criteria, and indices for assessing the health hazard for the population from contamination of air and wall structures of premises with permanent human presence by microscopic fungi.
Materials and methods. An analysis of domestic and foreign scientific reports and regulatory and methodological documents on the issue of assessing and regulating pollution of the indoor environment by microscopic fungi was carried out. A comparative assessment of the content of fungal flora in apartments of healthy individuals and individuals with allergy pathology was carried out, as well as an analysis of the results of population surveys using invasive and non-invasive research methods.
Results. Based on the analysis of scientific literature data and own research, there was made an assessment of the impact of various levels of microscopic fungi in indoor air on the health of residents. It was shown that with a mold concentration below 500 CFU/m³, the presence of visible fungal infection was not detected, and no effect on health was established. In the presence of visible foci of fungal infection of more than 5% of the total area of ​​​​the walls, floor, ceiling, the content of microscopic fungi in the air exceeds 1000 CFU/m³, in previous studies, with a mold content in the air over 1500 CFU/m³, an increase in the level of specific IgE in the blood serum in children was previously established, and in allergy sufferers, an exacerbation of allergic reponses is possible. When the content of microscopic fungi in the air is above 2000 CFU/m³ in the premises, there are lesions of more than 10% of the surface area of ​​enclosing structures, a reliable increase in allergic pathology and a reliable change in the cytological indices of the mucous membranes of the mouth and nose are noted.
Limitations. The results of this study do not apply to premises of livestock and poultry complexes, as well as biological industry enterprises.
Conclusion. The concentration of microscopic fungi in indoor air, not exceeding 500 CFU per 1 m³, can be considered as an acceptable level of their total content in the air of premises with constant occupancy. This concentration corresponds to the content of fungal spores in the atmospheric air, indicates to the absence of foci of fungal infection of wall structures, should not cause the development of allergic responses in healthy individuals and is consistent with WHO recommendations on the standardization of this factor.
Sanitary and epidemiological welfare in divers
Authors: Voronkova Svetlana V. , Avdienko Gennady Yu. , Vervedа Alexey B. , Lyovkina Yekaterina V. , Logunov Konstantin V.
Published: November 2024

Introduction. The issues of sanitary and epidemiological welfare in workers when performing diving operations require close attention from the state, are part of the structure of the Concept of development of diving in Russia, and are relevant to society. To date, there are several problems not only in hygienic rationing, but also in the medical provision of diving operations.
The purpose of the study is to study working conditions and subjective assessment of the health status of employees when performing diving operations, to develop proposals for improving legislation.
Materials and methods. The analysis of normative legal acts and scientific literature on the protection of the health and labor of divers is carried out. A survey of fifty diving workers was carried out.
Results. The main problems in the management of diving operations have been identified: in 15% of organizations there is no production control program, in 49% of organizations there is no therapeutic and preventive nutrition. There is no medical worker at the site of diving descents, if signs of decompression sickness or lung barotrauma are detected, therapeutic recompression is carried out in 46% of cases before the arrival of a diving doctor (paramedic) on their own. During the descents, 30% of respondents experienced fatigue, tiredness, headache, while all of them underwent mandatory medical examinations in private healthcare institutions; 18% of respondents indicated symptoms of hypothermia. At the same time, more than 60% of respondents were revealed to be subject to occupational burnout.
Limitation of the study is the lack of data on the results of preliminary and periodic medical examinations of respondents.
Conclusion. At the present stage, the system of ensuring sanitary and epidemiological welfare during diving operations requires improvement both in terms of state rationing, accounting and control, and compliance with health-saving preventive measures by employers and employees. In particular, attention should be paid to the direction of studying the development of occupational burnout in divers and to elaborate the system of prevention.
Creation of a database of historical control of hematological indices in rat blood to interpret the results of sanitary and toxicological studies of active substances of pesticides
Authors: Rakitsky Valery N. , Kuzmin Sergei V. , Еpishina Tatiana M. , Chkhvirkiya Elena G.
Published: November 2024

Introduction. Historical control data provide an understanding of the background variability (spontaneous changes) of the studied indices in the same species and line of animals, under similar conditions in the same laboratory, when assessing the toxic effects of repeated (manifold) administration of active substances of pesticides. The aim of the study was to create a database of historical control of hematological indices in rat blood used in chronic (twelve months) studies of active substances of pesticides of various chemical structures. Materials and methods. In accordance with the planned goal, a database of hematological blood indicces from control animals used in chronic (12 months) sanitary and toxicological studies of active substances of pesticides of various chemical structures has been created. The database contains information on 13 hematological indices in rat blood taken from control animals in dynamics after 1, 3, 6 and 12 months from the start of the study for the period 2017–2022. Studies of the active substances of pesticides were carried out in the biological testing laboratory of the Federal Scientific Center of Hygiene named after F.F. Erisman of the Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing according to the manual P 1.2.3156–13. Results. The results of the conducted studies indicate that in dynamics after 1, 3, 6 and 12 months of the study, a statistically significant increase in hemoglobin levels was detected in the blood of male rats. With the age, the animals showed a tendency to increase the concentration of red blood cells and platelets. Limitations. This article publishes a database of historical control of hematological parameters in rat blood, data on biochemical indices of blood serum and physiological indices in male rats in similar studies will be presented in the following publications. Conclusion. The results obtained will be used to substantiate the maximum inactive doses (NOEL), permissible daily doses (DSD), hygienic standards of the studied compounds in food and environmental objects.
Analysis of the interrelationship of indices of oxidative stress with cytogenetic indicators of genome instability in blood samples of Moscow residents
Authors: Khripach Lyudmila V. , Knyazeva Tatiana D. , Ingel Faina I. , Akhaltseva Lyudmila V. , Yurtseva Nadezhda A. , Nikitina Tatiana A. , Kedrova Anna G.
Published: November 2024

Introduction. Both mutagens and non-mutagenic chemical compounds, that can create conditions for a long-term shift in the oxidative balance in the body, contribute to increase of cancer risk in polluted regions.
The aim of the study. To assess the nature of relationships between indices of oxidant status and indicators of genome instability in micronuclear test using a sample of Moscow residents.
Materials and methods. The activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and malondialdehyde (MDA) content were determined in blood lysates of sixty nine Moscow residents (men of working age, 44 [38;58] years old), as well as 8-OHdG plasma content. Indicators of genome instability were determined in cytokinesis-block micronucleus assay of blood lymphocytes.
Results. The rate of PHA-stimulated lymphocyte proliferation was shown to depend on the ratio of GPx and SOD activities in blood lysates: GPx accelerates proliferation, SOD slows down, and the optimal marker is GPx/SOD (R=0.418; p=0.00035 for proliferation index). The effects observed coincide with those obtained earlier on stabilized lines of spontaneously dividing cells; the absence of CAT influence was established for the first time. The frequencies of nucleoplasmic bridges (NPM) in 2-nuclear, polynuclear, and dividing cells but not of micronuclei, “broken eggs” and protrusions were associated positively with CAT and GPx activities (additive effect with close values of partial correlation coefficients; z=16.4x+0.17y-5.38 at R=0.464; p=0.0004 for the proportion of dividing cells with NPM). Further research is needed to explain these findings. No relationship was found between the results of cytome analysis and integral markers of oxidative stress (MDA, 8-OHdG).
Limitations. It is possible that modified patterns will be obtained in polluted regions.
Conclusion. Parallel study of free radical and cytogenetic indicators with their relationship will contribute to the selection of optimal markers for human health monitoring in regions with elevated levels of radiation or pro-oxidant chemicals.