bluuebunny/crossref_metadata_2025 huggingface dataset:
Super-rotating protostellar jets
Authors: Matsushita Yuko , Takahashi Satoko , Ishii Shun , Tomisaka Kohji , Ho Paul , Carpenter John , Machida Masahiro
Published: September 2020

Protostellar jets are most striking phenomena in star-forming regions and considered to be an essential ingredient in the star formation process. Stars form in gravitationally collapsing clouds. The mass of protostar at its birth is equivalent to Jovian mass or 0.1 percent of the solar mass. After the birth, the protostar acquires its mass by accreting material from a surrounding rotation disk embedded in an infalling envelope that is a remnant of the natal cloud of the star. Protostellar jets are believed to expel the excess angular momentum from the circumstellar region that allows accretion on to the star. Here, we report the detection of super-rotating jets driven from a protostar FIR 6b (HOPS 60) in Orion Molecular Cloud-2. The jet rotation velocity exceeds 20kms-1 and the specific angular momentum of the jet is as large as ∼ 1022cm2s-1, which hitherto are the largest that have been observed in protostellar jets. The extraordinary large rotation velocity and specific angular momentum can be explained by a magnetohydrodynamic disk wind. This is clear evidence that magnetic fields play a crucial role for protostellar evolution and that angular momentum is removed by protostellar jets.
A probabilistic model to evaluate the effectiveness of main solutions to COVID-19 spreading in university buildings according to proximity and time-based consolidated criteria
Authors: D'Orazio Marco , Bernardini Gabriele , Quagliarini Enrico
Published: September 2020

Crowds in buildings open to the public can alter the occupants’ safety in different emergency conditions, including those related to a pandemic. In this sense, university buildings are one of the most relevant scenarios in which the COVID-19 event clearly pointed out the stakeholders’ needs toward safety issues, especially because of the possibility of day-to-day presences of the same users (i.e. students, teachers) and overcrowding causing long-lasting contacts with possible “infectors” in such closed environments. While waiting for the vaccine, as for other public buildings, policy-makers’ measures to limit (second) virus outbreaks combine individual’s strategies (facial masks), occupants’ capacity and access control to avoid lockdowns and ensure adequate conditions for occupants. Simulators could support effectiveness evaluations of such measures. To fill this gap, this work proposes a quick and probabilistic simulation model based on consolidated proximity and exposure-time-based rules for virus transmission (confirmed by international health organizations). The building occupancy is defined according to university schedule, identifying the main “attraction areas” in the building (classrooms, break-areas). Scenarios are defined in terms of occupants’ densities, mitigation strategies, virus-related aspects. The model is calibrated on experimental data and applied to a relevant university building. Results demonstrate the model capabilities. In the case study, occupants’ capacity limitation could support the adoption of surgical masks by users instead of FFPk masks (thus improving users’ comfort issues). Preliminary correlations to combine acceptable mask filters-occupants’ density are proposed to support stakeholders in organizing users’ presences in the building during the pandemic.
Interrupted time series analysis of the implementation of social distancing policy, its lifting and the mandate of wearing face masks in Iran to mitigate against COVID-19
Authors: Saki Mandana , Behzadifar Masoud , Behzadifar Meysam , Ghanbari Mahboubeh Khaton , Bakhtiari Ahad , Azari Samad , Gorji Hasan Abolghasem , Wu Jianhong , Bragazzi Nicola Luigi
Published: September 2020

BackgroundCOVID-19 was first reported in Wuhan, China, and has spread rapidly around the world. The purpose of this study was to investigate the effects of implementing social distancing policy, and the impact of its lifting, with the resumption of social contacts and activities, as well as the effects of mandating face masks on the temporal trend of new COVID-19 cases in Iran. Methods We employed the interrupted time series analysis (ITSA), which is a very valuable method that can be used to evaluate the impact of the implementation of various policies in the health sector to help health policy-makers make effective decisions. Daily data were collected from the Ministry of Health and Medical Education and the World Health Organization from 954 public hospitals and health center settings. Data were extracted 14 days before and after the implementation of each policy. Results were computed with their 95% confidence interval (CI) and p-values equal to or less than 0.05 were considered as statistically significant. All data were analyzed using the open-source software R Version 3.6.1 using the “nlme” and “car” packages.ResultsThe slope of changes in new confirmed cases following the implementation of the social distancing policy decreased by 118.79 (P <0.001). With the resumption of social and economic activities in all provinces except for Tehran, initially the number of new daily confirmed cases was 3300, which was statistically significant (P <0.001). The slope of changes due to the implementation of this policy was 47.89 (P <0.001). A similar trend was detected with the resumption of social and economic activities in Tehran. With the implementation of the policy of mandatory use of masks, the slope of changes showed a decrease of 25.84 (P <0.001). Conclusion Given the absence of effective drugs and vaccines against COVID-19, policy-makers have implemented non-pharmacological interventions to reduce the transmission of the disease and prevent more deaths. Social distancing may be unsustainable in the long-term, while wearing masks is both a cost-effective and efficacious measure to curb disease transmission.
High Impact Extension Programming with Instagram
Authors: Stock Melanie
Published: September 2020

The social media service Instagram is a popular public platform, but often underused tool to reach new demographics, reduce barriers, and perpetuate science-based information in extension. In the U.S. Intermountain West, Instagram was the top-rated platform for sharing information by predominantly new and female farmers. This article provides recommendations on key behaviors, goal setting, and quantifying impact on Instagram for extension programming. Accounts should target one niche or market, a consistent and personal voice, and regular communication (new content at least three times weekly). Unique and productive connections between extension personnel, community leaders, farmers, students, and public influencers expands programming. Tracking program accounts, including the number of followers and engagement rates, can assess program impacts and target market needs.
The effect of monetary and financial variables on share prices of Jordanian commercial banks
Authors: Ajmi Jameel Al-Dhaimesh Hel
Published: September 2020

This study aims to examine the effect of monetary and financial variables on share prices of Jordanian commercial banks for the period 2001–2018. The monetary variables used in the research include broad money supply, the interest rate on time deposits and inflation, while financial variables include both the deficit of the general budget and government expenditures, and the general government domestic debt. A multiple linear regression equation is designed using E-Views program to test this effect. The study shows that there is a significant positive effect of broad money supply, whereas a negative effect of the general budget deficit and a positive effect of the domestic debt on share prices of commercial banks in Jordan for the specified period. In contrast, there is no effect of both inflation and the interest rate on time deposits and government expenditures on the price of shares of Jordanian commercial banks. The study recommends taking into account the relationship between the variables mentioned in the prices of shares of commercial banks when setting monetary and financial policies by the central bank and the government to determine the extent to which these variables reflect share prices of Jordanian commercial banks. Overall, the regression model reached R2 = 0.63, and this means that 63% of the change in the share prices of Jordanian commercial banks is due to changes in the independent variables included in the model.
An Inducible Expression System for Recombinant Sca Proteins with an Autotransporter Domain from Orientia Tsutsugamushi in Escherichia coli
Authors: Cho Hyejin , Kim Kwang-Sun
Published: September 2020

Background:

Orientia tsutsugamushi (Ot) is an obligate, intracellular, gram-negative
bacterium causing scrub typhus. Some of its encoded proteins play key roles in the adhesion and internalization
of the Ot strain into host cells and are suitable resources for vaccine development and
tools for scrub typhus diagnosis. Surface cell antigen (Sca) proteins, classified as autotransporter
(AT) proteins, are one of the largest protein families involved in bacterial pathogenesis and can be
promising candidates for vaccine development. These proteins are typically large and contain inhibitory
domains; therefore, recombinant proteins without such domains have been evaluated for
this purpose. However, the expression for recombinant Sca proteins containing the AT domain,
which might largely affect their protective role against scrub typhus, has not been analyzed and optimized.

Objective:

In this study, we optimized expression and purification conditions for individual Ot Sca
protein fragments [ScaA (27–1461), ScaC (257–526), ScaD (26–998), and ScaE (35–760)] harboring
the AT domain.

Methods:

To this end, we subcloned sequences of codon-optimized DNA encoding Sca protein
fragments into the Escherichia coli expression vector. In addition, the expression condition for individual
Sca fragments was optimized, and the proteins were purified using one-step Ni-NTA column
method. The purified fractions were re-folded by serial dilution method, followed by BCA
quantification and densitometric analysis to estimate the yield and purity of proteins.

Results:

We prepared platforms for expression of recombinant Sca protein fragments [ScaA
(27–1461), ScaC (257–526), ScaD (26–998), and ScaE (35–760)] containing an AT domain without
the signal peptide and transmembrane (TM) domain. The protein yield per liter of culture with
>70% of purity was ScaC (257–576), ScaE (35–760), ScaD (26-998), and ScaA (27-1461) in order.

Conclusion:

Our results could be used to develop Sca AT-domain based vaccines and tools for
scrub typhus diagnosis with rapid and cost-effective ways.
Activated Carbon/MoO3: Efficient Catalyst for Green Synthesis of Chromeno[d]pyrimidinediones and Xanthenones
Authors: Mehr Niloofar Sabet , Abdolmohammadi Shahrzad , Afsharpour Maryam
Published: September 2020

Background:

Nanoscale metal oxide catalysts have been extensively employed in organic reactions because they have been found to influence the chemical and physical properties of bulk material. The chromene (benzopyran) nucleus constitutes the core structure in a major class of many biologically active compounds, and interest in their chemistry consequently continues because of their numerous biological activities. The xanthene (dibenzopyran) derivatives are classified as highly significant compounds which display a number of various bioactive properties. Pyrimidinones have also gained interest due to their remarkable biological utilization, such as antiviral, antibacterial, antihypertensive, antitumor, and calcium blockers effects.

Objective:

The aim of this work presented herein was to prepare activated carbon/MoO3 nanocomposite and explore its role as a green and recyclable catalyst for the synthesis of chromeno[d]pyrimidinediones and xanthenones under ethanol-drop grinding at room temperature.

Methods:

The activated carbon/MoO3 nanocomposite was prepared successfully via a simple route in which the carbonization of gums as new natural precursors was used for the synthesis of activated carbon. This nanocomposite was then effectively used in a reaction of 3,4-methylenedioxyphenol, aromatic aldehydes, and active methylene compounds, including 1,3-dimethylbarbituric acid and dimedone, to synthesize a series of chromeno[d]pyrimidinediones and xanthenones in high yields. The synthesized catalyst was characterized by Fourier transform infrared spectroscopy (FT-IR), Powder x-ray diffractometry (XRD), Scanning electron microscope (SEM), Raman spectroscopy, and also by TGA analysis. Confirmation of the structures of compounds 5(a-g) and 6(a-g) were also established with IR, 1H NMR, and 13C NMR spectroscopic data and also by elemental analyses.

Results:

A number of 6,8-dimethyl-10-phenyl-6,10-dihydro-7H-[1,3]dioxolo[4´,5´:6,7]chromeno[2,3- d]pyrimidine-7,9(8H)-diones and 7,7-dimethyl-10-(4-methylphenyl)-6,7,8,10-tetrahydro-9H-[1,3]dioxolo[ 4,5-b]xanthen-9-ones were effectively synthesized using activated carbon/MoO3 nanocomposite (0.05 gr) as a catalyst under ethanol-drop grinding at room temperature. The desired products were obtained in high yields (93-97%) within short reaction times (15-20 min).

Conclusion:

This paper investigates the catalytic potential of the synthesized activated carbon/MoO3 nanocomposite for the preparation of chromeno[d]pyrimidinediones and xanthenones under the ethanol-drop grinding procedure. The mildness of the reaction conditions, high yields of products, short reaction times, experimental simplicity, and avoiding the use of harmful solvents or reagents makes this procedure preferable for the synthesis of these compounds.
Inflammation Drives Alzheimer's Disease: Emphasis on 5-lipoxygenase Pathways
Authors: Siddiqui Aisha , Akhtar Sayeed , Shah Zahoor , Othman Iekhsan , Kumari Yatinesh
Published: September 2020

It is a known fact that inflammation affects several physiological processes, including
the functioning of the central nervous system. Additionally, impairment of lipid mechanisms/pathways
have been associated with a number of neurodegenerative disorders and Alzheimer’s Disease
(AD) is one of them. However, much attention has been given to the link between tau and beta-
amyloid hypothesis in AD pathogenesis/prognosis. Increasing evidences suggest that biologically
active lipid molecules could influence the pathophysiology of AD via a different mechanism of
inflammation. This review intends to highlight the role of inflammatory responses in the context of
AD with the emphasis on biochemical pathways of lipid metabolism enzyme, 5-lipoxygenase (5-
LO).
An Efficient, Green, Microwave-assisted Synthesis of Benzo[a]furo[2, 3-c]phenazine Derivatives with TiO2-SO3H as Cost-effective and Recyclable Catalyst under Solventfree Conditions
Authors: Taheri Milad , Mohebat Razieh , Moslemin Mohammad Hossein
Published: September 2020

Background:

A rapid, efficient, and environmentally benign procedure for the synthesis of novel furo
[2,3-c]phenazine derivatives has been developed via reactions of 2-hydroxynaphthalene-1,4-dione, arylglyoxals,
and indole in the presence of TiO2-SO3H-catalyst (TSAC) as a recyclable heterogeneous catalyst under solventfree
conditions using microwave irradiation.

Introduction:

This study describes a successful approach for the synthesis of 2-(4-bromophenyl)-1-(1H-indol-3-
yl) benzo[a]furo[2,3-c] phenazine in the presence of TiO2-SO3H-catalyst using microwave irradiation.

Objective:

In this paper, we report an efficient and convenient method for the synthesis of phenazine derivatives
from benzo[a]phenazin-5-ol, arylglyoxal derivatives, and indoles in the presence of TiO2-SO3H-catalyst under
microwave irradiation.

Materials and Methods:

All reagents and solvents were purchased from Merck and Aldrich and used without
further purification. 1H NMR spectra (DMSO) were recorded on the Gemini-500 MHz spectrophotometer with
TMS as an internal standard.

Results and Discussion:

To investigate the reaction conditions for the synthesis of 2-(4-bromophenyl)-1-(1Hindol-
3-yl) benzo[a]furo [2, 3-c] phenazine derivatives, we performed a reaction between 2-hydroxynaphthalene-
1,4-dione (1 mmol) and aromatic 1,2-diamines (1 mmol) as a model.

Conclusion:

We demonstrated a green and straightforward procedure for the efficient synthesis of novel benzo[
a]furo[2, 3-c] phenazine derivatives in high yields via a one-pot, four-component domino protocol by using
TiO2-SO3H as a mild, effective, non-toxic, and inexpensive solid acid catalyst without the addition of an organic
co-solvent.
The Chemistry of 4-(dicyanomethylene)-3-methyl-l-phenyl-2-pyrazoline-5-ones as a Privileged Scaffold in the Synthesis of Heterocycles
Authors: Gomaa Mohsen A.-M. , Ali Huda A.
Published: September 2020

Background :

The reactivity of 4-(dicyanomethylene)-3-methyl-l-phenyl-2-pyrazoline-5-one DCNP 1 and its derivatives makes it valuable as a building block for the synthesis of heterocyclic compounds like pyrazolo- imidazoles, -thiazoles, spiropyridines, spiropyrroles, spiropyrans, and others. As a number of publications have reported on the reactivity of DCNP and its derivatives, we compiled some features of this interesting molecule.

Objective:

This article aims to review the preparation of DCNP, its reactivity, and application in heterocyclic and dyes synthesis.

Conclusion:

In this review, we have provided an overview of recent progress in the chemistry of DCNP and its significance in the synthesis of various classes of heterocyclic compounds and dyes. The unique reactivity of DCNP offers unprecedentedly mild reaction conditions for the generation of versatile cynomethylene dyes from a wide range of precursors, including amines, α-aminocarboxylic acids, their esters, phenols, malononitriles, and azacrown ethers. We anticipate that more innovative transformations involving DCNP will continue to emerge in the near future.
The Smart Dual-Stimuli Responsive Nanoparticles for Controlled Anti-Tumor Drug Release and Cancer Therapy
Authors: Wu Feng , Qiu Fei , Wai-Keong Siew A. , Diao Yong
Published: September 2020

Background:

In recent years, the emergence of stimuli-responsive nanoparticles has made drug delivery
more efficient. As an intelligent and effective targeted delivery platform, it can reduce the side effects
generated during drug transportation while enhancing the treatment efficacy. The stimuli-responsive nanoparticles
can respond to different stimuli at corresponding times and locations to deliver and release their drugs and
associated therapeutic effects.

Objective:

This review aims to inform researchers on the latest advances in the application of dual-stimuli responsive
nanoparticles in precise drug delivery, with special attention to their design, drug release properties,
and therapeutic effects. Syntheses of nanoparticles with simultaneous or sequential responses to two or more
stimuli (pH-redox, pH-light, redox-light, temperature-magnetic, pH-redox-temperature, redox-enzyme-light,
etc.) and the applications of such responsivity properties for drugs control and release have become a hot topic
of recent research.

Methods:

A database of relevant information for the production of this review was sourced, screened and analyzed
from Pubmed, Web of Science, SciFinder by searching for the following keywords: “dual-stimuli responsive”,
“controlled release”, “cancer therapy”, “synergistic treatment”.

Results:

Notably, the nanoparticles with dual-stimuli responsive function have an excellent control effect on
drug delivery and release, playing a crucial part in the treatment of tumors. They can improve the encapsulation
and delivery efficiency of hydrophobic chemotherapy drugs, combine chemo-photothermal therapies, apply
imaging function in the diagnosis of tumors and even conduct multi-drug delivery to overcome Multi-Drug
Resistance (MDR).

Conclusion:

With the development of smart dual-stimuli responsive nanoparticles, cancer treatment methods
have become more diverse and effective. All the stimuli-responsive nanoparticles functionalities exhibit their
characteristics individually within the single nanosystem.
Human Brain Disorders: A Review
Authors: Naz Falaq , Siddique Yasir Hasan
Published: September 2020

Background:

Due to the stressful life, brain disorders are considered as a significant global healthcare problem. It has generated a great need for continuous research for understanding brain structure as well as functions in context to health and diseases.

Scope and Approach:

The structure and functions of the brain were questioned and studied since Ancient Greek times and led to the compilation of enormous information on the subject globally. With the advent of new technology, the researchers are able to discover the causes of brain diseases/disorders.

Conclusion:

In the present review, we have compiled various diseases and disorders related to the brain, along with their symptoms and the treatment strategies.
Pharmacological Aspects of Phyllanthus fraternus Standardized Extract (Rich in Lignans and Tannins) as a Pain Modulator
Authors: Chopade Atul R. , Patil Pramod A. , Mali Suraj N.
Published: September 2020

Background:

The standardized extracts of P. fraternus were previously reported by us for its anti-inflammatory, analgesic, and anti-arthritic biological potentials. However, we have not reported for a consequence of P. fraternus on chronic inflammatory muscle hyperalgesia. Herein, we have demonstrated chronic pain modulating effect of standardized extracts of P. fraternus.

Materials and Methods:

Firstly, we have collected various parts of P. fraternus plant including the dried stems, leaves, and roots. In order to produce chronic inflammations, we further allowed injection to the left gastrocnemius muscle belly of rats with a freshly prepared solution of 3% carrageenan in normal saline (100µL). Thermal/heat hyperalgesia, mechanical hyperalgesia and muscle circumferences were determined in the current experimental model. In order to estimate, chronic pain modulating potential of P. fraternus, we have also studied histopathological studies and measurement of prostaglandin E-2 (PGE2).

Results:

After administration of 3% carrageenan intramuscular injection, we investigated the chronic thermal and mechanical hypersensitivity of aforementioned test sample i.e. standardized extracts of P. fraternus in terms of adopting 2 gradual dosings of 200 and 400 mg/kg (administered intraperitoneally) from day 14th to 22nd. From our study, we observed significant antihyperalgesic activity; when we allowed administering standardized extracts of P. fraternus intraperitoneally.

Conclusion:

To conclude, we have investigated the antihyperalgesic and anti-inflammatory potentials of standardized extracts of P. fraternus. These effects might be having mediation via supraspinal or spinal neuronal mechanisms, and mainly observed due to evidence of PGE2 inhibitions.
Epidemiological situation of a new coronavirus infection (COVID-19) in the Rostov region: analysis and forecast
Authors: Kovalev E. V. , Tverdokhlebova T. I. , Karpushenko G. V. , Erganova E. G. , Agafonova V. V. , Ryndich A. A. , Suladze A. G. , Kolpakov D. S. , Dolgova N. N. , Aleksanina N. V. , Aleshukina A. V. , Litovko A. R. , Aleshukin G. S. , Denisenko V. V.
Published: September 2020

Objective: monitoring, analysis and forecast of the spread of new coronavirus infection (COVID-19) in the Rostov region.

Materials and methods: analysis of data on the incidence of COVID-19 in the Rostov region, obtained on the basis of agencies: Department of the Federal service for supervision of consumer protection and human welfare in the Rostov region, Center of hygiene and epidemiology in Rostov region, Rostov research Institute of Microbiology and Parasitology, as well as the monitoring of information on the Internet sites of the Government of the Rostov region and the regional headquarters for the fight against the spread of COVID-19. Application of the SEIR analytical platform to build a mathematical model for predicting the spread of infection in the Rostov region.

Results: the article presents an analysis of the epidemiological situation for the incidence of COVID-19 in the Rostov region, analyzes the effectiveness of preventive and anti-epidemic measures with the ability to predict the development of the epidemiological process in the region.
Sanitary and parasitological monitoring of environmental objects in the Rostov region
Authors: Tverdokhlebova T. I. , Dimidova L. L. , Khutoryanina I. V. , Chernikova M. P. , Dumbadze O. S. , Коvalev E. V. , Karpushchenko G. V. , Nenadskaya S. A.
Published: September 2020

Objective: to study the sanitary condition of various environmental objects of the Rostov region and the degree of their contamination.

Materials and methods: in the period from 2015 to 2019, more than 5600 sanitary and parasitological studies of environmental objects of the Rostov region were performed on the basis of the Rostov Research Institute of Microbiology and Parasitology: waste water and its precipitation, soil, water of open surface reservoirs. The work was carried out in accordance with the accepted normative documents.

Results: it was found that 33.4 % of all tested samples were positive, and 1.4% of the samples contained viable eggs of various pathogens of helminthiasis and did not meet the requirements of regulatory documents.

Conclusions: the results of the study indicate that the environmental objects of the Rostov region are polluted with parasitic pathogens and their unsatisfactory sanitary and parasitological condition.
organizaciones en el marco de los sistemas complejos: Una aproximación desde la literatura científica
Authors: Yábar Ben Yusef
Published: September 2020

La presente revisión se origina por la contraposición entre la teoría burocrática y la teoría orgánica, en virtud a la vez de la contraposición de los sistemas simples y los sistemas complejos. Revisa los desarrollos de las ciencias de la complejidad, la autopoiesis organizacional y las metodologías para el estudio de las organizaciones y de los sistemas organizacionales. Con respecto a las ciencias de la complejidad se aborda la termodinámica del no equilibrio, la teoría del caos, la geometría de fractales, la teoría de las catástrofes y las lógicas no clásicas; en cuanto a la autopoiesis organizacional, se toma como punto de partida la autupoiesis biológica y la autopoiesis organizacional; finalmente con respecto a la metodologías aplicadas para el estudio de las organizaciones y los sistemas organizacionales se considera: el análisis de sistemas complejos, la sociología de la acción organizada, el modelo basado en agentes, el sistema multi-agente y el sistema de acción concreta.
Alexander the Great’s “Argolai” and “Lenii Levi”: On the Difficulties of Translation of The Life of the Prophet Jeremiah into Russian
Authors: Kirillin Vladimir M.
Published: September 2020

This article, bearing on facts and data from ancient mythology, a novel about Alexander the Great and other Greek-Latin sources, as well as taking into account Greek and Slavic etymology, folk, and ritual customs, reveals the possible serpentine meaning of the words “Argolai” and “lenii levi.” The words are found in the Slavic translation of the Greek text The Life of the Prophet Jeremiah that was included in the 1499 copy of the Bible 1499 as a preface to the eponomous Old Testament book, but also, as it turned out, existed in collections Explanatory Prophets and Prologue. However, clarification of the cultural and historical context allowed me to suggest that these enigmatic words were related to the symbolic essence of material details of the cult objects. The article also demonstrates how these words reflect linguistic and lexical peculiarities of the activities of St. Gennady followers and the scribes at the end of the 15th century in general.
Valery Brusov. 1890 Journal Entries
Authors: Bogomolov Nikolay A. , Gayduk Vladislava L.
Published: September 2020

This is the first unabridged publication of the fragment of Valery Bryusov’s journal. In this fragment, Bryusov describes the events of the summer, autumn, and winter of 1890. During this period, he leaves F. Kreiman’s gymnasium and enters L. Polivanov’s gymnasium. The journal gives an idea of the poet’s personal life: his circle of friends, family, life, study, hobbies, etc. Bryusov also describes his first poetic experiments. The authors of this publication not only attempt to decipher the entire textual material but also compare the text with the material prepared for publication by the poet’s wife I.M. Bryusova. The foreword analyzes journal entries in detail and outlines the history of the publication of Bryusov’s journals. The journal is provided with a detailed historical and literary commentary.
Vasily Ilmenev “Explanatory Dictionary”
Authors: Gracheva Alla M.
Published: September 2020

This publication introduces a hitherto unknown text by Alexey Remizov, previously not included in bibliographic references. Remizov’s “Explanatory Dictionary,” published under the pseudonym “Vasily Ilmenev” is a review of the first volume of the Explanatory Dictionary of the Russian Language edited by D.N. Ushakov (Moscow, 1935). The attribution and analysis of the “Explanatory Dictionary” have allowed me to qualify it as a work with artistic value that may be thematically and stylistically included in a series of Remizov’s prose miniatures in the two volumes of Remizov’s book Russia in Letters. As his sources, Remizov used a number of dictionary articles that recorded and explained words that were relevant in the USSR before 1937 (“to brand,” “to slander,” “denunciation,” etc.). The inclusion of the miniature “Explanatory Dictionary” in the writer’s legacy better understanding of the writer’s attitude to the Stalin regime. It is an unusual work for Remizov as it openly expresses the author’s political views.
Letramento digital na Educação de Jovens e Adultos: uma experiência no Colégio de Aplicação da UFRGS
Authors: Bocasanta Daiane Martins , Rapkiewicz Clevi Elena
Published: September 2020

Resumo: O presente relato de experiência tem como objetivo descrever atividades pedagógicas de letramento digital realizadas com alunos de uma turma de alfabetização e pós-alfabetização da Educação de Jovens e Adultos (EJA), de uma escola pública federal de Porto Alegre (RS). Tais atividades foram elaboradas a partir de um diagnóstico inicial das necessidades da turma, numa parceria estabelecida entre a professora polivalente (pedagoga) e a professora de Cultura Digital. O planejamento, posto em prática durante o primeiro semestre do ano de 2019, esteve centrado em atividades que desmistificassem o uso de tecnologias digitais, tais como computadores e smartphones. Do mesmo modo, as professoras também privilegiaram o reaproveitamento de lixo eletrônico, na desmontagem de artefatos (mouses e teclados, entre outros) para o entendimento do funcionamento dos mesmos e na ressignificação desses na produção de novos objetos, como um alfabeto para a sala de aula e jogos pedagógicos.Palavras-chave: Educação de Jovens e Adultos; Tecnologias Digitais; Lixo eletrônico.
Práticas inovadoras no trabalho com a disciplina de Matemática no Ensino Fundamental I: uma revisão sistemática
Authors: Elias Ana Paula de Andrade Janz , Zoppo Beatriz Maria , Kalinke Marco Aurélio
Published: September 2020

Esta pesquisa tem por objetivo apresentar quais as práticas inovadoras que professores que atuam no Ensino Fundamental I têm desenvolvido no ensino da disciplina de Matemática, que estão sendo divulgadas no meio acadêmico. Optou-se pelo Ensino Fundamental I, por esse nível de ensino contemplar a base do Ensino da Matemática. A pesquisa foi realizada por meio de uma revisão sistemática no Banco de Teses e Dissertações (BDTD) no segundo semestre de 2019. Os resultados demonstraram que os jogos, o trabalho com a Etnomatemática, o uso de tecnologias digitais, a Modelagem Matemática e a utilização de histórias podem ser usados como práticas inovadoras que oportunizam aos estudantes vivenciarem situações nas quais os conceitos matemáticos possam ser abordados de maneira reflexiva e contextualizada, fazendo sentido para a sua aprendizagem.
Problemas de gênero nos anos iniciais do ensino fundamental e na educação física: questões e proposições.
Authors: Assis Amanda Dória de
Published: September 2020

O presente trabalho constitui-se como um relato de experiência que problematiza gênero na escola. Viso socializar algumas questões de gênero emergentes do contexto escolar e algumas proposições realizadas. O trabalho referido foi realizado em uma escola da Rede Municipal de Ensino de Porto Alegre no ano letivo de 2018, com turmas do terceiro ano do Ensino Fundamental.
The Chicago Group of Four That Changed Accounting Research
Authors: Takeshima Sadaharu , Sorter George H.
Published: September 2020

This manuscript provides a historical account of the “Chicago Group of Four,” namely, Sidney Davidson, Charles T. Horngren, David O. Green, and George H. Sorter, and describes their activities and individual roles based on Sorter's autobiography in 2019. The Chicago group was a major source of accounting innovation, both initiating the empirical research conferences at The University of Chicago and establishing the Journal of Accounting Research.
MODELAMIENTO MATEMÁTICO DEL COMPORTAMIENTO EPIDEMIOLÓGICO DE LA PANDEMIA COVID-19 EN CHINA
Authors: Marín-Machuca Olegario , Zambrano-Cabanillas Abel Walter , García-Talledo Enrique Gustavo , Ortiz-Guizado Julia Iraida , Vivas-Ruiz Dan Erick , Marín-Sánchez Obert
Published: September 2020

El objetivo del trabajo fue desarrollar un modelo matemático que haga la predicción del comportamiento epidemiológico causado por SARS-CoV2 (COVID-19) en la República Popular de China. El modelo de basó en determinar la relación entre la variación del número de casos reportados (dN) y la variación del tiempo transcurrido (dt), denominado velocidad con que el fenómeno de casos reportados en China. La velocidad del fenómeno se determinó por diferenciación gráfica, con el propósito de encontrar una Ecuación Diferencial Ordinaria de Primer Orden (EDOPO), tipo lineal. Esta ecuación fue resuelta entre las condiciones iniciales de los datos reportados (t=1 día, N=278 casos reportados), llegando a obtener el modelo predictivo correspondiente. El modelo predictivo (Ecuación 15) fue validado estadísticamente, evaluando su coeficiente de correlación r de Pearson, cuyo valor es de 0,97, indicando una buena estimación del modelo en relación con el comportamiento epidemiológico de COVID-19.
que nos dizem tutores e alunos sobre a evasão em cursos de educação a distância em uma instituição de ensino superior?
Authors: Helal Rodrigo Machado Cavalcante , Mazzafera Bernadete Lema , Rolim Anderson Teixeira
Published: September 2020

Recentemente, a taxa de evasão na Educação a Distância (EaD) foi um dos principais problemas enfrentados pelas instituições brasileiras de ensino superior. O objetivo deste estudo é analisar as razões citadas por alunos e tutores para desistência de cursos na modalidade de educação a distância, em uma Instituição de Ensino Superior (IES) de Brasília. Para responder à questão, realizou-se uma pesquisa descritiva por meio da análise de documentos, entrevistas e aplicação de questionários com tutores e ex-alunos. A análise documental destacou questões acadêmicas como principal motivo. Os alunos entrevistados citaram a mudança de tutor, a necessidade de trabalhar e pouco tempo para se dedicar aos estudos. Os tutores destacaram a falta de tempo para estudar e dificuldades em relação a modalidade de ensino. Diante dos resultados, novas pesquisas são necessárias que explorem as características dos cursos na instituição pesquisada associando-as aos fatores acadêmicos citados pelos alunos.
Stem Biomass Equation of Eucalyptus urophylla S.T. Blake
Authors: Patabang Melewanto , Dising Julianus , Adrin Adrin , Almulqu Aah Ahmad
Published: September 2020

Eucalyptus urophylla is one of the typical plants of the Province of East Nusa Tenggara,  Indonesia whose distribution includes the islands of Timor, Alor, Wetor, Flores, Adonara, Lomblen, and Pantar. The best land for the growth of E. urophylla is an area with rainfall above 1000 mm every year. E. urophylla dominate the island of Timor hence the potential to absorb carbon and store it in biomass as part of climate change mitigation. This study aims to determine the allometric equation model to predict the potential of E. urophylla stem biomass. Calculation of the amount of stem biomass based on allometric equations is an analytical method used in this study. The sample trees used in equation modeling is 100 trees as a result of the inventory. The equations that can be used to estimate the biomass potential of the stem of  E. urophylla in Timor Island were ln  = -2.12 + 2.472 ln ( ) and (R2= 0.98); ln  = -3.617 + 1.046 ln  and (R2= 0.99); and ln  = -3.510 + 2.157 ln ( ) + 0.983 ln  and (R2= 0.99). The stem biomass potential with the model I amounting to 276.877 tons ha-1, model II of 279.671 tons ha-1, and model III of 280.209 tons ha-1.
Synergism of Phage фPT1b and Antibiotics for Reducing Infection of Escherichia coli
Authors: Narulita Erlia , Aji Gerda Permata , Wahono Bevo , Murdiyah Siti , Yulian Ria
Published: September 2020

Foodborne disease caused by Escherichia coli contamination is increasing every year. It also followed by elevating of drug-resistance of E. coli. Bacteriophage can be an alternative for therapy infection.  This study aimed to determine synergism effect of bacteriophage ϕPT1b which has a high rate virulence to E. coli and phage-antibiotics (tetracycline and amoxicillin) synergy. The indigenous bacteria isolates were KR, MJ, KP, PT, PR. Five bacteriophages used namely ϕKR1b, ϕKR2, ϕPT1a, ϕPT1b, and ϕMJ1b. Virulence test was used to determine the ability of each phage in reducing E. coli. Treatment to examine synergism of phage ϕPT1b and antibiotics were P1: amoxicillin, P2: ϕPT1b, P3: ϕPT1b + Amx = 1:1, P4 : ϕPT1b + Amx = 2:1, P5: ϕPT1b + Amx = 1:2, P6 : tetracycline, P2: ϕPT1b, P7: ϕPT1b + Tet = 1:1, P8 : ϕPT1b + Tet = 2:1, and P9: ϕPT1b + Tet = 1:2. The virulence test showed that isolate ϕPT1a with 106 CFU/ml had the highest ability in reducing E. coli. While, the result of synergism test indicated that the synergism of bacteriophage and antibiotics differ significantly (P ≤ 0.05). The best ratios of synergism were 1:1 (ϕPT1b+tetracycline) and 2:1 (ϕPT1b+amoxicilline). In summarize, phage-antibiotic synergy (ϕPT1b with tetracycline/amoxicilline) can reduce the level of antibiotic resistance in isolated E. coli.
Enhancing the productivity performance of Cyprinus carpio L. by Manihot utilissima Pohl. leaves supplementation
Authors: Efianda Teuku Reza , Sari Uci Elfana , Humeira Humeira , Ananda Kiki Rishki
Published: September 2020

Cyprinus carpio is an economically crucial freshwater commodity in Indonesia and across the globe. Fish demand has a rising trend, which not in line with productivity. Innovation and aspects of food safety are the primary keys to increasing productive capacity. Therefore, the utilization of Manihot utilissima leaves as an alternative to improve national fish's productivity rate is a worthy consideration. They have multiple nutrients, including protein and fat needed by C. carpio seeds. This study aims to determine the optimal dose of M. utilissima supplementation to increase the productivity of C. carpio seeds. The methodology consisted of four treatments (0.5 mL/250 g, 10 mL/250 g, 15 mL/250 g) with four replications for 21 days. The outcome showed that P4 treatment (15 mL) could increase the relative growth rate by 21.10%/day, and it decreased the feed conversion ratio by 0.84. However, there is no significant effect on the survival rate. The study concludes that P4 treatment (15 mL) has positively increased the relative growth rate of C. carpio, and decreased its feed conversion ratio.
IMPLEMENTASI MANAJEMEN KURIKULUM PADA PENDIDIKAN ANAK USIA DINI SULAPA EPPA
Authors: Kusyairi Umi , Sartika Ika Dewi , Hidayah Husnul , Hartati Sri , Nurhidayat Nurhidayat
Published: September 2020

Penelitian ini bertujuan untuk mengetahui proses perencanaan, pelaksanaan atau penerapan, dan pengembangan kurikulum di PAUD Sulapa Eppa Jenis penelitian ini menggunakan penelitian deskriptif kualitatif. Subjek penelitian adalah kepala sekolah PAUD Sulapa Eppa. Pengumpulan data dilakukan melalui teknik indepth interview (wawancara mendalam), observasi, dokumentasi dan angket. Hasil penelitian menunjukkan: 1) Perencanaan kurikulum dilakukan setiap semester, di rancang jauh sebelum proses pembelajaran, serta di evaluasi setiap semester. Perencanaan kurikulum di PAUD Sulapa Eppa dilakukan dengan mengadaptasi kurikulum SISDIKNAS yang diintegrasikan dengan Visi dan Misi sekolah, serta unsur manusia pada PAUD Sulapa Eppa itu sendiri lalu di cantumkan ke dalam kurikulum. 2) Pelaksanaan kurikulum PAUD Sulapa Eppa tetap mengacu pada kurikulum nasional, namun memiliki ciri khas khusus yaitu penekanan pada empat muatan karakter: a) macca (pintar), b) malempu (jujur), c) warani (berani) dan d) magetteng (teguh pendirian) yang harus ada di setiap pelaksanaan tema pembelajaran. 3) Pengembangan kurikulum PAUD Sulapa Eppa sesuai dengan kebutuhan anak, jika memiliki kemampuan pemahaman yang cepat, maka materi pembelajaran akan di tambah. Kurikulum SISDIKNAS tidak langsung di terapkan dalam pembelajaran, namun  di analisis dan di evaluasi sesuai dengan kebutuhan anak untuk semester selanjutnya.
GEN REGULASI TANAMAN LOKAL INDONESIA: IMUNOMODULATOR COVID-19
Authors: Aziz Isna Rasdianah , Armita Devi , Hajrah Hajrah , Makmur Kurnia
Published: September 2020

Pandemi COVID-19 yang melanda seluruh dunia pada akhir tahun 2019 meresahkan semua kalangan. Di tengah kekhawatiran tersebut, pada peneliti terus mengembangkan vaksin dan obat-obatan untuk memerangi serangan virus SARS-CoV-2 tersebut. Tak terkecuali, tanaman lokal berbagai Negara, termasuk Indonesia yang diyakini mampu memberi sumbangsih perbaikan imun sebagai upaya pencegahan dan pertahanan imun. Tanaman lokal mampu berperan sebagai imunomodulator karena kapabilitasnya menghasilkan senyawa bioaktif tertentu. Regulasi ekspresi gen berperan langsung pada biosintesis senyawa bioaktif dalam tanaman lokal tersebut.
Duas Pandemias: Um Esboço Comparativo entre a “Pneumónica” 1918-19 e a COVID-19
Authors: Sobral José Manuel
Published: September 2020

A pandemia atual de COVID-19 trouxe à memória a grande pandemia de gripe de 1918-19, conhecida em Portugal como “Pneumónica”, a única recente que se lhe pode comparar em termos dos efeitos disruptivos provocados. Embora a comparação entre um fenómeno datado no tempo, como a primeira, e um outro que ainda se desenrola, com efeitos imprevisíveis, comporte riscos, assume-se ser útil proceder desde já a uma comparação entre ambas as pandemias, que permita detetar semelhanças e diferenças entre ambas e os contextos em que ocorreram.
Troponina Elevada e Lesão Miocárdica em Doentes Internados em Medicina Interna : Significado Diagnóstico e Prognóstico
Authors: Carrington Mafalda , Jacinto Margarida , Sousa Ana , Sant'Anna Joana , Muñoz José , Tribolet de Abreu Tiago
Published: September 2020

Introdução: A elevação de troponina é frequente nos doentes internados. O seu significado e classificação (lesão miocárdica crónica versus aguda versus enfarte agudo de miocárdio (EAM), quer tipo 1, quer tipo 2) não se encontram esclarecidos. O objectivo deste estudo foi avaliar o significado e classificar as elevações de troponina em doentes internados numa enfermaria de Medicina Interna.

Material e Métodos: Estudo retrospectivo de doentes internados, num período de dois anos, numa enfermaria de Medicina Interna, a quem foram pedidos, pelo menos, 2 doseamentos de troponina I, ao critério do médico assistente, e que tiveram pelo menos um valor acima do limite de referência de 0,1 ng/ mL. A população foi caracterizada quanto à demografia, factores de risco cardiovascular, antecedentes clínicos, achados clínicos e laboratoriais, terapêutica efectuada e prognóstico. Foi interpretada a elevação de troponina de acordo com a quarta definição de EAM.

Resultados: Foram incluídos 90 doentes, com idade média de 83 anos (± 8,1), sendo 52% do sexo masculino. Cumpriram critérios de EAM 60 doentes (66%), sendo que os restantes 30 doentes (33%) eram classificáveis como lesão miocárdica aguda, sem EAM. Não encontrámos diferenças clínicas, no tratamento e prognóstico entre estes dois grupos de doentes, à excepção da idade (84 ± 7 vs 81 ± 10 anos, respectivamente, p = 0,039). Os doentes tinham um performance status baixo (43% ECOG 3 ou 4), hipertensão arterial (89%), insuficiência cardíaca (51%), diabetes mellitus tipo 2 (50%), insuficiência renal crónica (35%), fibrilhação auricular ou flutter (35%) e enfarte agudo de miocárdio prévio (33%). A apresentação clínica incluiu dispneia em 44% e dor torácica em 13%. À data da alta, 64% dos doentes foram medicados com estatina e 58% com pelo menos um anti-agregante plaquetário. A morte ocorreu durante o internamento em 17%, sendo que a mortalidade a 30 dias foi de 27% e a um ano de 51%.

Conclusão: Neste estudo, verificámos que, dos doentes com elevação de troponina compatível com lesão miocárdica internados numa enfermaria de Medicina Interna, 66% cumpriam os critérios de definição de EAM, enquanto os restantes 33% tinham lesão miocárdica aguda, sem EAM. À excepção da idade (mais elevada nos doentes com EAM) não houve diferença significativa nas características clínicas, abordagem ou prognóstico entre os dois grupos. Os doentes eram idosos e frágeis, com múltiplas comorbilidades, tendo a morte ocorrido duran-te o internamento em 17%, aos 30 dias em 27% e ao 1 ano em 51%, apesar de prescrição de estatina em 64% e de antiagregação em 60%.
PROBLEMATIKA PEMBERDAYAAN MASYARAKAT MISKIN
Authors: Haris Muhammad
Published: September 2020

Abstact

Purpose of the study was to determine the problematics empowering poor. Research uses the literature review method, collecting data using a literacy analysis related to the empowerment process and observing empowerment programs. Results of the study explained that the problem of empowering poor people occurred in empowering time efficiency, understanding the empowerment programs. The factors causing these problems are: a). the lack of synchronization between central and practitioner empowerment planning. b). not yet in accordance with the application of the empowerment method in the midst of diversity. c). the use of the old paradigm in community empowerment. d). understanding of cultural values that are cloused.

Keywords: Problems, Empowerment, Poor

Abstrak

Tujuan penelitian ini untuk mengetahui problematika pemberdayaan masyarakat miskin. Penelitian menggunakan metode kajian pustaka, pengumpulan data menggunakan analisis literasi yang berkaitan dengan proses pemberdayan dan melakukan observasi pada program-program pemberdayaan. Hasil penelitian menjelaskan problematika pemberdayaan masyarakat miskin terjadi pada efisiensi waktu pemberdayaan,pemahaman paradigma pemberdayaan, penggunaan metode pemberdayaan, penggunaan materi pemberdayaan, program pemberdayaan tidak berkelanjutan. Adapun faktor penyebab problematika tersebut yaitu: a). belum singkronnya perencanaan pemberdayaan pusat dan praktisi. b). belum sesuai penerapan metode pemberdayaan di tengah keberagaman. c). penggunaan paradigma lama dalam pemberdayaan masyarakat. d). pemahaman nilai budaya yang tertutup.

Kata Kunci: Problematika, Pemberdayaan, Masyarakat Miskin