bluuebunny/crossref_metadata_2025 huggingface dataset:
Self-Assembly-Directed Exciton Diffusion in Solution-Processable Metalloporphyrin Thin Films
Authors: Shibu Abhishek , Middleton Camilla , Kwiatkowski Carly O. , Kaushal Meesha , Gillen Jonathan H. , Walter Michael G.
Published: December 2021

The study of excited-state energy diffusion has had an important impact in the development and optimization of organic electronics. For instance, optimizing excited-state energy migration in the photoactive layer in an organic solar cell device has been shown to yield efficient solar energy conversion. Despite the crucial role that energy migration plays in molecular electronic device physics, there is still a great deal to be explored to establish how molecular orientation impacts energy diffusion mechanisms. In this work, we have synthesized a new library of solution-processable, Zn (alkoxycarbonyl)phenylporphyrins containing butyl (ZnTCB4PP), hexyl (ZnTCH4PP), 2-ethylhexyl (ZnTCEH4PP), and octyl (ZnTCO4PP) alkoxycarbonyl groups. We establish that, by varying the length of the peripheral alkyl chains on the metalloporphyrin macrocycle, preferential orientation and molecular self-assembly is observed in solution-processed thin films. The resultant arrangement of molecules consequently affects the electronic and photophysical characteristics of the metalloporphyrin thin films. The various molecular arrangements in the porphyrin thin films and their resultant impact were determined using UV-Vis absorption spectroscopy, steady-state and time-resolved fluorescence emission lifetimes, and X-ray diffraction in thin films. The films were doped with C60 quencher molecules and the change in fluorescence was measured to derive a relative quenching efficiency. Using emission decay, relative quenching efficiency, and dopant volume fraction as input, insights on exciton diffusion coefficient and exciton diffusion lengths were obtained from a Monte Carlo simulation. The octyl derivative (ZnTCO4PP) showed the strongest relative fluorescence quenching and, therefore, the highest exciton diffusion coefficient (5.29 × 10−3 cm2 s−1) and longest exciton diffusion length (~81 nm). The octyl derivative also showed the strongest out-of-plane stacking among the metalloporphyrins studied. This work demonstrates how molecular self-assembly can be used to modulate and direct exciton diffusion in solution-processable metalloporphyrin thin films engineered for optoelectronic and photonic applications.
Thermodynamic Stability of Fenclorim and Clopyralid
Authors: Almeida Ana R. R. P. , Pinheiro Bruno D. A. , Lobo Ferreira Ana I. M. C. , Monte Manuel J. S.
Published: December 2021

The present work reports an experimental thermodynamic study of two nitrogen heterocyclic organic compounds, fenclorim and clopyralid, that have been used as herbicides. The sublimation vapor pressures of fenclorim (4,6-dichloro-2-phenylpyrimidine) and of clopyralid (3,6-dichloro-2-pyridinecarboxylic acid) were measured, at different temperatures, using a Knudsen mass-loss effusion technique. The vapor pressures of both crystalline and liquid (including supercooled liquid) phases of fenclorim were also determined using a static method based on capacitance diaphragm manometers. The experimental results enabled accurate determination of the standard molar enthalpies, entropies and Gibbs energies of sublimation for both compounds and of vaporization for fenclorim, allowing a phase diagram representation of the (p,T) results, in the neighborhood of the triple point of this compound. The temperatures and molar enthalpies of fusion of the two compounds studied were determined using differential scanning calorimetry. The standard isobaric molar heat capacities of the two crystalline compounds were determined at 298.15 K, using drop calorimetry. The gas phase thermodynamic properties of the two compounds were estimated through ab initio calculations, at the G3(MP2)//B3LYP level, and their thermodynamic stability was evaluated in the gaseous and crystalline phases, considering the calculated values of the standard Gibbs energies of formation, at 298.15 K. All these data, together with other physical and chemical properties, will be useful to predict the mobility and environmental distribution of these two compounds.
Copper(II) Phenanthroline-Based Complexes as Potential AntiCancer Drugs: A Walkthrough on the Mechanisms of Action
Authors: Masuri Sebastiano , Vaňhara Petr , Cabiddu Maria Grazia , Moráň Lukáš , Havel Josef , Cadoni Enzo , Pivetta Tiziana
Published: December 2021

Copper is an endogenous metal ion that has been studied to prepare a new antitumoral agent with less side-effects. Copper is involved as a cofactor in several enzymes, in ROS production, in the promotion of tumor progression, metastasis, and angiogenesis, and has been found at high levels in serum and tissues of several types of human cancers. Under these circumstances, two strategies are commonly followed in the development of novel anticancer Copper-based drugs: the sequestration of free Copper ions and the synthesis of Copper complexes that trigger cell death. The latter strategy has been followed in the last 40 years and many reviews have covered the anticancer properties of a broad spectrum of Copper complexes, showing that the activity of these compounds is often multi factored. In this work, we would like to focus on the anticancer properties of mixed Cu(II) complexes bearing substituted or unsubstituted 1,10-phenanthroline based ligands and different classes of inorganic and organic auxiliary ligands. For each metal complex, information regarding the tested cell lines and the mechanistic studies will be reported and discussed. The exerted action mechanisms were presented according to the auxiliary ligand/s, the metallic centers, and the increasing complexity of the compound structures.
Biomass-Derived Porous Carbon from Agar as an Anode Material for Lithium-Ion Batteries
Authors: Issatayev Nurbolat , Kalimuldina Gulnur , Nurpeissova Arailym , Bakenov Zhumabay
Published: December 2021

New porous activated carbons with a high surface area as an anode material for lithium-ion batteries (LIBs) were synthesized by a one-step, sustainable, and environmentally friendly method. Four chemical activators—H2SO4, H3PO4, KOH, and ZnCl2—have been investigated as facilitators of the formation of the porous structure of activated carbon (AC) from an agar precursor. The study of the materials by Brunauer–Emmett–Teller (BET) and scanning electron microscopy (SEM) methods revealed its highly porous meso- and macro-structure. Among the used chemical activators, the AC prepared with the addition of KOH demonstrated the best electrochemical performance upon its reaction with lithium metal. The initial discharge capacity reached 931 mAh g−1 and a reversible capacity of 320 mAh g−1 was maintained over 100 cycles at 0.1 C. High rate cycling tests up to 10 C demonstrated stable cycling performance of the AC from agar.
Soft Magnetic Properties of Ultra-Strong and Nanocrystalline Pearlitic Wires
Authors: Wurster Stefan , Stückler Martin , Weissitsch Lukas , Krenn Heinz , Hohenwarter Anton , Pippan Reinhard , Bachmaier Andrea
Published: December 2021

The paper describes the capability of magnetic softening of a coarse-grained bulk material by a severe deformation technique. Connecting the microstructure with magnetic properties, the coercive field decreases dramatically for grains smaller than the magnetic exchange length. This makes the investigation of soft magnetic properties of severely drawn pearlitic wires very interesting. With the help of the starting two-phase microstructure, it is possible to substantially refine the material, which allows the investigation of magnetic properties for nanocrystalline bulk material. Compared to the coarse-grained initial, pearlitic state, the coercivities of the highly deformed wires decrease while the saturation magnetization values increase—even beyond the value expectable from the individual constituents. The lowest coercivity in the drawn state is found to be 520 A m−1 for a wire of 24-µm thickness and an annealing treatment has a further positive effect on it. The decreasing coercivity is discussed in the framework of two opposing models: grain refinement on the one hand and dissolution of cementite on the other hand. Auxiliary measurements give a clear indication for the latter model, delivering a sufficient description of the observed evolution of magnetic properties.
Modelling Thermal Conduction in Polydispersed and Sintered Nanoparticle Aggregates
Authors: Karagiannakis Nikolaos P. , Skouras Eugene D. , Burganos Vasilis N.
Published: December 2021

Nanoparticle aggregation has been found to be crucial for the thermal properties of nanofluids and their performance as heating or cooling agents. Most relevant studies in the literature consider particles of uniform size with point contact only. A number of forces and mechanisms are expected to lead to deviation from this ideal description. In fact, size uniformity is difficult to achieve in practice; also, overlapping of particles within aggregates may occur. In the present study, the effects of polydispersity and sintering on the effective thermal conductivity of particle aggregates are investigated. A simulation method has been developed that is capable of producing aggregates made up of polydispersed particles with tailored morphological properties. Modelling of the sintering process is implemented in a fashion that is dictated by mass conservation and the desired degree of overlapping. A noticeable decrease in the thermal conductivity is observed for elevated polydispersity levels compared to that of aggregates of monodisperse particles with the same morphological properties. Sintered nanoaggregates offer wider conduction paths through the coalescence of neighbouring particles. It was found that there exists a certain sintering degree of monomers that offers the largest improvement in heat performance.
Recent Advances in Green-Solvent-Processable Organic Photovoltaics
Authors: Gaspar Hugo , Bernardo Gabriel , Mendes Adélio
Published: December 2021

Over the last four years, tremendous progress has occurred in the field of organic photovoltaics (OPVs) and the champion power conversion efficiency (PCE) under AM1.5G conditions, as certified by the National Renewable Energy Laboratory (NREL), is currently 18.2%. However, these champion state-of-the-art devices were fabricated at lab-scale using highly toxic halogenated solvents which are harmful to human health and to the environment. The transition of OPVs from the lab to large-scale production and commercialization requires the transition from halogenated-solvent-processing to green-solvent-processing without compromising the device’s performance. This review focuses on the most recent research efforts, performed since the year 2018 onwards, in the development of green-solvent-processable OPVs and discusses the three main strategies that are being pursued to achieve the proposed goal, namely, (i) molecular engineering of novel donors and acceptors, (ii) solvent selection, and (iii) nanoparticle ink technology.
Qualitative and Quantitative Detection of Potentially Virulent Vibrio parahaemolyticus in Drinking Water and Commonly Consumed Aquatic Products by Loop-Mediated Isothermal Amplification
Authors: Shen Zhengke , Liu Yue , Chen Lanming
Published: December 2021

Vibrio parahaemolyticus can cause acute gastroenteritis, wound infection, and septicemia in humans. In this study, a simple, specific, and user-friendly diagnostic tool was developed for the first time for the qualitative and quantitative detection of toxins and infection process-associated genes opaR, vpadF, tlh, and ureC in V. parahaemolyticus using the loop-mediated isothermal amplification (LAMP) technique. Three pairs of specific inner, outer, and loop primers were designed for targeting each of these genes, and the results showed no cross-reaction with the other common Vibrios and non-Vibrios pathogenic bacteria. Positive results in the one-step LAMP reaction (at 65 °C for 45 min) were identified by a change to light green and the emission of bright green fluorescence under visible light and UV light (302 nm), respectively. The lowest limit of detection (LOD) for the target genes ranged from 1.46 × 10−5 to 1.85 × 10−3 ng/reaction (25 µL) for the genomic DNA, and from 1.03 × 10−2 to 1.73 × 100 CFU/reaction (25 µL) for the cell culture of V. parahaemolyticus. The usefulness of the developed method was demonstrated by the fact that the bacterium could be detected in water from various sources and commonly consumed aquatic product samples. The presence of opaR and tlh genes in the Parabramis pekinensis intestine indicated a risk of potentially virulent V. parahaemolyticus in the fish.
Clinical Utility and Cost Effectiveness of Long-Acting Lipoglycopeptides Used in Deep-Seated Infections among Patients with Social and Economic Barriers to Care
Authors: Antosz Kayla , Al-Hasan Majdi N. , Lu Z. Kevin , Tabor Benjamin , Justo Julie Ann , Milgrom Alexander , Kohn Joseph , Bookstaver P. Brandon
Published: December 2021

The use of long-acting lipoglycopeptides (LaLGPs) in serious, deep-seated infections is of increasing interest. The purpose of this study is to evaluate the economic and clinical utility of LaLGPs in patients requiring protracted antibiotic courses who are not ideal candidates for oral transition or outpatient parenteral antibiotic therapy (OPAT). This is a retrospective, observational, matched cohort study of adult patients who received a LaLGP. Patients were matched 1:1 to those who received standard of care (SOC). Cost effectiveness was evaluated as total healthcare-related costs between groups. Clinical failure was a composite endpoint of mortality, recurrence, or need for extended antibiotics beyond planned course within 90 days of initial infection. There was no difference in clinical failure between the two cohorts (22% vs. 30%; p = 0.491). Six patients in the SOC cohort left against medical advice (AMA) prior to completing therapy. Among those who did not leave AMA, receipt of LaLGPs resulted in a decreased hospital length of stay by an average of 13.6 days. The average total healthcare-related cost of care was USD 295,589 in the LaLGP cohort compared to USD 326,089 in the SOC cohort (p = 0.282). Receipt of LaLGPs may be a beneficial treatment option for patients with deep-seated infections and socioeconomic factors who are not candidates for oral transition or OPAT.
Classification of Plant Leaves Using New Compact Convolutional Neural Network Models
Authors: Wagle Shivali Amit , Harikrishnan R. , Ali Sawal Hamid Md , Faseehuddin Mohammad
Published: December 2021

Precision crop safety relies on automated systems for detecting and classifying plants. This work proposes the detection and classification of nine species of plants of the PlantVillage dataset using the proposed developed compact convolutional neural networks and AlexNet with transfer learning. The models are trained using plant leaf data with different data augmentations. The data augmentation shows a significant improvement in classification accuracy. The proposed models are also used for the classification of 32 classes of the Flavia dataset. The proposed developed N1 model has a classification accuracy of 99.45%, N2 model has a classification accuracy of 99.65%, N3 model has a classification accuracy of 99.55%, and AlexNet has a classification accuracy of 99.73% for the PlantVillage dataset. In comparison to AlexNet, the proposed models are compact and need less training time. The proposed N1 model takes 34.58%, the proposed N2 model takes 18.25%, and the N3 model takes 20.23% less training time than AlexNet. The N1 model and N3 models are size 14.8 MB making it 92.67% compact, and the N2 model is 29.7 MB which makes it 85.29% compact as compared to AlexNet. The proposed models are giving good accuracy in classifying plant leaf, as well as diseases in tomato plant leaves.
Cross-Linking Combined with Surfactant Bilayer Assembly Enhances the Hydrophilic and Antifouling Properties of PTFE Microfiltration Membranes
Authors: Xu Shijie , Ma Wenzhong , Yang Haicun , Cao Zheng , Gong Fanghong , Liu Chunlin
Published: December 2021

The inherent strong hydrophobicity of Polytetrafluoroetylene (PTFE) microfiltration membranes results in low separation efficiency and easy contamination. In order to enhance its hydrophilic and antifouling properties, we first modified the PTFE microfiltration membrane by using Polyethylene glycol laurate (PEGML) for first layer deposition and then used Polyvinyl alcohol (PVA)/citric acid (CA) cross-linked coatings for second layer deposition. The Scanning Electron Microscope (SEM) results showed that the fibers and nodes of the modified PTFE microfiltration membrane were coated with PVA/CA hydrophilic coating. FT-IR Spectromete and X-ray photoelectron spectrometer (XPS) analysis results confirmed that crosslinking of PVA and CA occurred and that PEGML and PVA/CA were successfully deposited onto the membrane surface. The modification conditions were optimized by hydrophilicity testing, and the best hydrophilicity of the modified membrane was achieved when the crosslinking content of PEGML was 2 g·L−1, PVA was 5 g·L−1, and CA was 2 g·L−1. PTFE microfiltration membranes modified by the optimal conditions achieved a water flux of 396.9 L·m−2·h−1 (three times that of the original membrane) at low operating pressures (0.05 MPa), and the contact angle decreased from 120° to 40°. Meanwhile, the modified PTFE microfiltration membrane has improved contamination resistance and good stability of the hydrophilic coating.
Can a Paradigm Shift from Risk Management to Critical Reflection Improve Child-Inclusive Practice?
Authors: Morley Christine , Clarke Joanne , Leggatt-Cook Chez , Shkalla Donna
Published: December 2021

Child protection systems within Anglophone countries have been increasingly dominated by neoliberal managerial, risk-dominant paradigms over the past three decades. Assumed to deliver a cost-effective strategy to increase the safety of children, there are many ways this paradigmatic combination systematically undermines child welfare, participation, and well-being. This paper specifically focuses on the ways that risk assessment, neoliberal, and managerial discourses have infiltrated practice and operate to silence and exclude children’s voices. It draws on two case studies to showcase key findings of a comprehensive, state-wide research project called Empowering Children’s Voices, which was initiated by UnitingCare, a non-government organisation within Queensland, Australia, and conducted in partnership with researchers from Queensland University of Technology. It will be argued that a paradigm shift towards a critically reflective reinterpretation of risk can be far more effective at promoting child-inclusive practice and establishing children’s empowered voices as a protective factor against harm.
Soil Chemistry and Clay Mineralogy of an Alluvial Chronosequence from the North Carolina Sandhills of the Upper Coastal Plain, USA
Authors: Suther Bradley E. , Leigh David S. , West Larry T.
Published: December 2021

Temporal changes in soil development were assessed on fluvial terraces of the Little River in the upper Coastal Plain of North Carolina. We examined five profiles from each of six surfaces spanning about 100,000 years. Soil-age relationships were evaluated with inter-surface clay mineral comparisons and regression of chemical properties versus previously reported optically-stimulated luminescence ages using the most developed subsoil horizon per profile. Bases to alumina (Bases/Al2O3) ratios have negative correlations with age, whereas dithionite-Fe (FeD) concentrations are positively correlated with time and differentiate floodplain (<200 yr BP) from terrace (≥10 ± 2 ka) soils and T4 pedons (75 ± 10 ka) from younger (T1-T3b, 10 ± 2–55 ± 15 ka) and older (T5b, 94 ± 16 ka) profiles. Entisols develop into Ultisols with exponentially decreasing Bases/Al2O3 ratios, reflecting rapid weatherable mineral depletion and alumina enrichment during argillic horizon development in the first 13–21 kyr of pedogenesis. Increasing FeD represents transformation and illuviation of free Fe inherited from parent sediments. Within ~80–110 kyr, a mixed clay mineral assemblage becomes dominated by kaolinite and gibbsite. Argillic horizons form by illuviation, secondary mineral transformations, and potentially, a bioturbation-translocation mechanism, in which clays distributed within generally sandy deposits are transported to surface horizons by ants and termites and later illuviated to subsoils. T5b profiles have FeD concentrations similar to, and gibbsite abundances greater than, those of pedons on 0.6–1.6 Ma terraces along Coastal Plain rivers that also drain the Appalachian Piedmont. This is likely because the greater permeability and lower weatherable mineral contents of sandy, Coastal Plain-sourced Little River alluvium favor more rapid weathering, gibbsite formation, and Fe translocation than the finer-grained, mineralogically mixed sediments of Piedmont-draining rivers. Therefore, recognizing provenance-related textural and mineralogical distinctions is crucial for evaluating regional chronosequences.
MXene: Evolutions in Chemical Synthesis and Recent Advances in Applications
Authors: Biswas Sayani , Alegaonkar Prashant S.
Published: December 2021

Two-dimensional materials have secured a novel area of research in material science after the emergence of graphene. Now, a new family of 2D material-MXene is gradually growing and making itsmark in this field of study. MXenes since 2011 have been synthesized and experimented on in several ways.The HF treatment although successful poses some serious problems that gradually propelled the ideas of new synthesis methods. This review of the literature covers the major breakthroughs of MXene from the year of its discovery to recent endeavors, highlighting how the synthesis mechanisms have been developed over the years and also the importance of good characterization of data. Results and properties of this class of materials arealso briefly discussed alongwith recent advance in applications.
Intrathoracic Giant Mass with Anomalous Vascular Origin in an Asymptomatic Patient: A Case Report
Authors: Solinas Michela , Conti Valentina , Grignani Fabrizio
Published: December 2021

Diagnostic and surgical difficulties were presented in case of a giant mass, found incidentally, in a 65-year-old healthy and asymptomatic man. The patient underwent different diagnostic procedures. Surgery was the treatment of choice. A combination of both open technique and videothoracoscopy to reduce the risk of seeding, pending a certain diagnosis, was resolutive. The postoperative period and recovery time were uneventful. The patient was discharged on the 5th postoperative day. The histological diagnosis was benign schwannoma. There are different aspects to think about, based also on the experience of each center. According to our experience, this is a rare situation; the combined surgical techniques to control the vascular risk and tissue infiltration of the mass seemed to us the approach of choice.
Cerebral Venous Thrombosis: A Challenging Diagnosis; A New Nonenhanced Computed Tomography Standardized Semi-Quantitative Method
Authors: Romano Andrea , Rossi-Espagnet Maria Camilla , Pasquini Luca , Di Napoli Alberto , Dellepiane Francesco , Butera Giulia , Moltoni Giulia , Gagliardo Olga , Bozzao Alessandro
Published: December 2021

Cerebral venous sinus thrombosis (CVST) on non-contrast CT (NCCT) is often challenging to detect. We retrospectively selected 41 children and 36 adults with confirmed CVST and two age-matched control groups with comparable initial symptoms. We evaluated NCCT placing four small circular ROIs in standardized regions of the cerebral dural venous system. The mean and maximum HU values were considered from each ROI, and the relative percentage variations were calculated (mean % variation and maximum % variation). We compared the highest measured value to the remaining three HU values through an ad-hoc formula based on the assumption that the thrombosed sinus has higher attenuation compared with the healthy sinuses. Percentage variations were employed to reflect how the attenuation of the thrombosed sinus deviates from the unaffected counterparts. The attenuation of the affected sinus was increased in patients with CVST, and consequently both the mean % and maximum % variations were increased. A mean % variation value of 12.97 and a maximum % variation value of 10.14 were found to be useful to distinguish patients with CVST from healthy subjects, with high sensitivity and specificity. Increased densitometric values were present in the site of venous thrombosis. A systematic, blind evaluation of the brain venous system can assist radiologists in identifying patients who need or do not need further imaging.
Evaluation of a Yeast Hydrolysate from a Novel Strain of Saccharomyces cerevisiae for Mycotoxin Mitigation using In Vitro and In Vivo Models
Authors: Bruinenberg Paul Gerard , Castex Mathieu
Published: December 2021

Mycotoxicoses in animals are caused by exposure to mycotoxin-contaminated feeds. Disease risk is managed using dietary adsorbing agents which reduce oral bioavailability. The objective of this work was to evaluate the efficacy of three selected yeast products as mycotoxin binders using in vitro and in vivo models. Their capacity to adsorb deoxynivalenol (DON), zearalenone (ZEA), and ochratoxin A (OTA) was evaluated using an in vitro model designed to simulate the pH conditions during gastric passage in a monogastric animal. Results showed that only one product, an enzymatic yeast hydrolysate (YHY) of a novel strain Saccharomyces cerevisiae, adsorbed about 45% of DON in solution. Next, we determined the effect of YHY on oral absorption of a DON, ZEA, and OTA mixture using a toxicokinetic model in swine. Toxicokinetic modeling of the plasma concentration-time profiles of DON, OTA, and zearalenone-glucuronide (ZEA-GlcA) showed that YHY tended to reduce the maximal plasma concentration of OTA by 17%. YHY did not reduce oral bioavailability of OTA, DON, and ZEA-GlcA. Within the context of this experiment, and despite some positive indications from both the in vitro and in vivo models employed, we conclude that the YHY prototype was not an effective agent for multiple mycotoxin adsorption.
How Well Does Evolution Explain Endogenous Retroviruses?—A Lakatosian Assessment
Authors: Jorritsma Ruben
Published: December 2021

One of the most sophisticated philosophies of science is the methodology of scientific research programmes (MSRP), developed by Imre Lakatos. According to MSRP, scientists are working within so-called research programmes, consisting of a hard core of fixed convictions and a flexible protective belt of auxiliary hypotheses. Anomalies are accommodated by changes to the protective belt that do not affect the hard core. Under MSRP, research programmes are appraised as ‘progressive’ if they successfully predict novel facts but are judged as ‘degenerative’ if they merely offer ad hoc solutions to anomalies. This paper applies these criteria to the evolutionary research programme as it has performed during half a century of ERV research. It describes the early history of the field and the emergence of the endogenization-amplification theory on the origins of retroviral-like sequences. It then discusses various predictions and postdictions that were generated by the programme, regarding orthologous ERVs in different species, the presence of target site duplications and the divergence of long terminal repeats, and appraises how the programme has dealt with data that did not conform to initial expectations. It is concluded that the evolutionary research programme has been progressive with regard to the issues here examined.
Influence of sectoral trends in business process management in e-commerce
Authors: Skliar Dmytro
Published: December 2021

The article considers the specifics of e-commerce sphere development and determines the main directions of industry trends influence on the business process management. The need to develop on the basis of analytical data of scientific and practical tools and recommendations that define and characterize the relationship between industry trends and the trajectory of e-commerce enterprises development is actualized. The context and conditions of modern e-commerce enterprises activity are described, including the issues of development of this sphere under the influence of restrictive measures related to the coronavirus pandemic COVID-19. The need for the effective response of the e-commerce enterprise to certain tendencies is actualized, the necessity of adaptation of management of this enterprise to change of managing conditions, technological and institutional transformations is noted. Problems have been identified and scientific and practical solutions have been formed, focused on improving of e-commerce enterprises efficiency under the influence of environmental factors. The most influential factors that characterize the practice of economic entities functioning in the field of e-commerce at the current stage at the global level are determined. The leading industry trends and conditions of activity in the field of e-commerce are studied and the impact of these trends on the enterprises management in the field of e-commerce is characterized. The strategic guidelines are defined and substantiated, the basic preconditions are outlined and scientific and practical recommendations are given to increase the efficiency of e-commerce enterprises management in modern business conditions in the context of the impact of intra-industry trends. The preconditions for the transformation of business process management practices in e-commerce under the influence of these trends are analyzed
Current trends of Ukraine’s categorized hotels development
Authors: Shykina Olga
Published: December 2021

The article analyzes the current state of categorized hotels in Ukraine, their dynamics for 2018–2021 and distribution by regions. The activity of the State Agency for the Tourism Development of Ukraine on the establishment of categories of hotels, with the subsequent identification of the main trends and frequency of obtaining the declared category by the hotel is investigated. The main motives for obtaining a category by modern hotels are summarized. The existence of a relationship between the selected target audience and the decision to undergo categorization by the hotel was identified. The influence of new requirements for hotels receiving permission to organize and conduct gambling on the rapid growth in demand for hotels to undergo the categorization procedure has been determined. The register of permits issued by the Gambling and Lottery Regulatory Commission was investigated and compared with a list of hotels that had recently been categorized and re-examined of an existing category. It is predicted that by the end of the year there will be a significant increase in the number of categorized hotels in the whole country, and specifically in Kyiv. The place of the Odessa region among other administrative-territorial units of Ukraine was determined by the number of categorized hotels for 2018–2021. The characteristic of the main trends that distinguish the Odessa region from the list of categorized hotels from other regions of Ukraine is given. The main changes that took place in the Odessa region in the context of various categories of hotels are revealed. The distribution of categorized hotels with more than one hundred rooms has been investigated. The dependence of the location of hotels and the result of their categorization is substantiated. The existing tendencies regarding categorized hotels in Ukraine are determined, including the uneven distribution by region, the revival of the rate of obtaining the category by hotels after the entry into force of the Law of Ukraine on state regulation of activities for the organization and conduct of gambling, positioning the Odessa region as the region with the largest number of «five stars» hotels. Suggestions for further research on this issue are given.
Ethical policy management processes research on the example of Ukrainian universities
Authors: Revtiuk Yevhen
Published: December 2021

The article considers the processes of development and implementation of ethical policy in higher education institutions on the examples of Ukrainian universities. The aim of the study is effectiveness assessing of management processes for ethical policy implementation in domestic universities. The object of the research is the twenty top-rated universities in Ukraine, according to the 2021 Consolidated Rating of Higher Education Institutions. In the proposed study, the method of content analysis was used for analysis of regulatory documents in the field of ethical policy of selected universities. The analysis focuses on the proposed basic criteria that characterize the effectiveness of the ethical policy implementation, namely, on availability: approved ethical programs; an officials responsible for implementing programs; ethical training; feedback systems; developed motivational mechanisms; ethical audit procedures; procedures for reviewing ethical programs. As a result of the study, problems are identified related to the implementation of ethical policies that are specific to the universities in question, namely: the formalistic nature of ethical programs, the lack of responsible persons for the policies implementation (ethical officers), the focus of ethical trainings solely on improving academic integrity, the lack of effective feedback systems, refusal to use employee motivation systems to comply with ethical standards, the lack of ethical audit, the lack of procedures for verifying the ethical standards of new employees. The elements of ethical policy management, which will allow its effective implementation in domestic universities, are proposed. The study should help the university management corps to use ethics more effectively as a management tool.
DEVELOPMENT OF CREATIVITY OF THE FUTURE MANAGER OF THE EDUKATIONAL INSTITUTION
Authors: BUTSKIVSKA T.
Published: December 2021

The article considers the issue of training competitive future managers in the field of education. The main directions of formation of the future leader are analyzed, the basic tools of formation of professional competence of such leader and features of use of such tools are presented.

The author concludes that in order for educational institutions in Ukraine to move to the level of innovation and meet the demands of society, it is necessary to improve the system of training future managers in the field of education, develop and implement creative processes. After all, in developed countries it is becoming a common practice and the main source of competitive advantage. In modern management, the management of the processes of formation and use of creative potential refers to "creative management". That is why the introduction of creative management in the field of education and in our country is becoming important.

Further research is due to the transformation of social and economic relations and is related to the development of methods for preparing future managers to work in educational institutions on the basis of creativity.
FORMS OF EXISTENCE OF LAW IN THE PEDAGOGICAL THEORY AND PRACTICE OF AS MAKARENKO
Authors: KARABUT Yu.
Published: December 2021

The article deals with the problem of using the experience of AS Makarenko in modern educational practice, in particular, the legal education of children and youth. A.S. As a teacher, Makarenko left a lot of evidence of how juvenile delinquents became law-abiding citizens. From these positions, the forms of existence of law, reflected in its theoretical and practical heritage, are of considerable interest for the implementation of effective educational impact on young people.In the context of the children's team, whose members were freed from anarchic, criminal in many ways on the basis of upbringing and education, such forms (levels) of law as legal consciousness (awareness of the need to coexist on legal grounds) can be traced; legal norms - orderly rules that everyone who did not want to be outside the human community was forced to follow; legal relations - a system of relations that, providing the requests of the individual, did not contradict the most universally recognized requests of the whole community.The author concludes that analyzing the experience of A.S. Makarenko and considering the law as an order of social relations, which is manifested in the actions and behavior of people, we observe in the institutions headed by a prominent teacher, the personal progress of students as conscious subjects of legal relations. There is reason to conclude that this process reflects the main goals and means of Makarenko's educational system as such and further study will reveal more generalized, and therefore important for today's conditions, pedagogical principles of legal education of children and youth.
INNOVATIVE FORMS OF SEMINAR LESSONS IN THE PROCESS OF PROFESSIONAL GROWTH OF MASTERS OF THE EDUCATIONAL PROGRAM "PEDAGOGY OF HIGHER SCHOOL"
Authors: KONONETS N. , NESTULA S.
Published: December 2021

The essence of innovative forms of organization of seminars in the process of professional growth of undergraduates of the educational program "Pedagogy of higher school" in the field of knowledge 01 Education / Pedagogy of specialty 011 Educational, pedagogical sciences is analyzed in the work. The following forms of innovative seminars that will promote the professional growth of undergraduates while studying in higher education are characterized: seminar-extended conversation, seminar-report (message), discussion of abstracts and creative works, annotated reading, seminar-problem solving, in the form of a TV program, seminar-debate (discussion), seminar-conference, seminar-press conference, problem seminar, seminar-auction, seminar-quiz, seminar-competition (tournament), webinar.

Analysis of the most popular types of seminars allows us to talk about the crucial role of the teacher's creative approach to the process of their implementation. Such creative seminars are received with interest by masters of the educational program "Higher School Pedagogy", because they, as future teachers of free economic education, professional higher education will introduce the same organizational forms of learning in future professional activities. At the same time, holding such seminars will promote the professional growth of undergraduates while studying in the Free Economic Zone. Summarizing the above, we note that innovative forms of organizing the educational activities of undergraduates provide high cognitive activity and interest in the study of pedagogical disciplines, improve the ability to work with multiple sources, compare the same issues, express their views in collective discussion of common problems. and summarize the knowledge gained.
MANAGEMENT COMPETENCE OF THE FUTURE SERVICE MANAGER: ORGANIZATIONAL AND METHODMETHODICAL COMPONENTS
Authors: KRAVCHENKO L. , ONIPKO V.
Published: December 2021

The article presents an analysis of the process of formation of managerial competence of future specialists in the field of service (on the example of hotel and restaurant business) in the course of professional training in institutions of higher and higher education. Based on the research of scientists on the training of future specialists in the field, a number of organizational and methodological competencies have been identified; the definition of "managerial competence of future service managers" is interpreted as a multicomponent dynamic combination of management knowledge, organizational skills, skills to train staff, ways of thinking, views, values, relevant personal qualities, implemented at the level of higher education 24 "Service Area 24" "Hotel and restaurant business. It is proved that structurally such competence is an integrated set of integrated, general ("soft" skills) and special ("hard" professional, subject, managerial and professional skills) competencies and determines the ability of the future manager to successfully conduct professional activities, purposefully improve professional the level of management and leadership in his subordinate staff of the hotel and restaurant company, build a career and create your own concept of success in life. The organizational competencies include the following: knowledge of the theoretical foundations of the organization of the process of providing services, forms, tools, methods and techniques of organizing the cognitive activities of staff; structure, psychological and pedagogical aspects of communication in the enterprise or the entrusted team; types of formal, semi-formal and informal methods of decision-making and implementation; ability to analyze organizational environments, prepare strategic and operational plans, appropriate measures and procedures; implement tasks based on the positive aspects of each employee. To methodical competences - mobility of knowledge (constant updating of the information for the successful decision of problems in concrete conditions); flexibility of methods (application of methods depending on conditions), critical thinking (creativity, non-standard, originality of design), responsibility for actions and decisions.
PREPARATION OF THE CIRCUIT LEADER TO TEACH STUDENTS IN TECHNICAL MODELING
Authors: KUDRIA O.
Published: December 2021

The rapid pace of transformation in the society of Ukraine and the world, the process of its integration into the educational space of Europe contributed to increasing the focus on the quality of children's leisure, the need to review and improve the legal framework for out-of-school education. The article analyzes the features of teaching pupils of technical modeling and professional training of future teachers to  activities in out-of-school education institutions. The purpose of the article is to analyze the specifics of teaching pupils  technical modeling in out-of-school educational institutions that have scientific and technical direction, and substantiation of scientific and methodological foundations and features of training teachers of labor training and technology for professional activities in out-of-school education.

Peculiarities of preparation of future teachers of labor education and technologies for teaching puiples in the conditions of out-of-school education institutions are considered. On the basis of the analysis of scientific and methodical literature the concept training of future teachers of labor training and technologies for professional activity on training of pupils of technical modeling in establishments of out-of-school education which have a scientific and technical direction is defined. Emphasis is placed on the priority of the motivational component in the process of implementing the competence approach of the educational system in the training of both future teachers and pupils.

Аspects of construction of structural-semantic model are characterized training of future teachers of labor education and technologies for professional activity in out-of-school education institutions. The organizational and pedagogical conditions of effective student learning are determined. The necessity of forming in students the skills of integration of branch knowledge and combination of educational methods, technologies of organization of classes during the practice of teaching technical modeling in the process of classes in out-of-school education institutions is substantiated.
PEDAGOGICAL ASPECTS OF APPLICATION OF WOODWORKING TECHNOLOGIES IN LESSONS OF LABOR TRAINING
Authors: LOGVINIUK O.
Published: December 2021

The article reveals the content of readiness of students of pedagogical ZVO, future teachers, ability to comprehensively solve problems of labor, moral and aesthetic education of secondary school students. The pedagogical conditions of effective pedagogical influence in the formation of knowledge, skills and work with wood are considered.

Successful mastering by students of woodworking technologies at lessons of labor training is provided by principles (clarity, individualization, connection of the theory with practice, manufacturability, reflexivity, partnership and cooperation, interdisciplinary communications, professional orientation of training), modern methodical approaches (system, activity, technology , personal, etc.), pedagogical conditions based on the professional skills of the teacher, provide for the development of students' love for work, nature and the preservation of the experience of folk crafts.

The work of students with natural materials is of great importance for the aesthetic education of children, instilling in them artistic taste, development of creative abilities, imagination. The overriding task of working with natural material is to awaken in children a love for native nature, which contributes to the education of their patriotic feelings. It is time to further improve the methodological training of teachers of labor education in order to expand their learning opportunities.
HIGHER EDUCATION IN UKRAINE IN THE CONVENTION OF THE COVID-19 PANDEMIC: NEW CHALLENGES AND PROSPECTS
Authors: MATVIICHUK O. , MATVIICHUK A. , YEROMENKO R. , GLADCHENKO O. , TARAN A.
Published: December 2021

The article is devoted to the analysis of the problems of introduction of distance learning in higher educational institutions of Ukraine. The article presents the results of an anonymous survey of research and teaching staff and students of higher education institutions on the use of distance learning technologies in the conditions of national quarantine, conducted by the State Education Quality Service of Ukraine. According to the results of the survey, conclusions were made about the degree of effectiveness and further prospects for the introduction of new teaching methods in a pandemic.

In order to identify achievements, possible difficulties and determine the main trends in the further development of distance technologies, the State Service for the Quality of Education of Ukraine conducted an anonymous survey of scientific and pedagogical workers and students of higher education institutions on the use of distance learning technologies in conditions of national quarantine. The survey was conducted from 23.04. to 05.05.2020. 28 391 respondents took part in the survey - 22367 students and 6024 scientific and pedagogical workers.

As a result of the research, conclusions were drawn that the distance learning technologies in Ukraine and in the world are rapidly developing and are a promising tool for the provision of educational services.

Thus, the introduction of quarantine during the COVID-19 coronavirus pandemic revealed not only new problems in higher education in Ukraine, but also new challenges and opportunities for higher education institutions from three points of view: for students, this is an experience of self-discipline and self-education; for teachers - the use of new methods and tools of distance learning; for structural divisions of universities, this is practical testing of the technical capabilities of distance learning; defining a clear distance learning strategy, where students not only gain knowledge, but also cooperate with teachers in a feedback mode; awareness of the need to quickly master the volume of home education.