bluuebunny/crossref_metadata_2025 huggingface dataset:
Biological decolourization of textile industry wastewater by a developed bacterial consortium
Authors: Madhushika Hewayalage Gimhani , Ariyadasa Thilini U. , Gunawardena Sanja H. P.
Published: January 2020

Most currently employed textile effluent decolourization methods use physical and chemical processes where dyes do not get degraded instead concentrated or transferred into a solid phase. Therefore, further treatment processes are required to destroy dyes from the environment. In contrast, biological decolourization may result in degradation of the dye structure due to microbial activities and hence biological processes can be considered environmentally friendly. In the present study, bacterial strains with dye decolourization potential were isolated from the natural environment and their ability to decolourize four different reactive textile dyes was studied individually and in a bacterial consortium. The developed bacterial consortium composed with Proteus mirabilis, Morganella morganii and Enterobacter cloacae indicated more than 90% color removals for all four dyes and optimum decolourization of the dye mixture was observed at 40 °C and pH 7. The developed bacterial consortium decolourized 60% of dyes in textile industry effluent at 35 °C and pH 7 showing their ability to endure in highly complex and toxic environments and application in textile industry wastewaters.
Mapeamento de competências: necessidades de aprimoramento de analistas periciais em contabilidade do Ministério Público Federal
Authors: Prates Ariel , Sallaberry Jonatas Dutra , Flach Leonardo , Peleias Ivam Ricardo , Souza Romina Batista de Lucena
Published: January 2020

Objetivo: O estudo tem como objetivo analisar as competências dos analistas da área pericial contábil lotados no Ministério Público Federal (MPF), de forma a apresentar por nível de importância aquelas que possuem maior necessidade de aprimoramento.

Metodologia: O desenvolvimento da pesquisa ocorreu por meio da tipologia descritiva, com abordagem quantitativa. A técnica empregada foi pesquisa survey, a partir de um questionário estruturado com 37 questões, aplicados em escala tipo Likert de sete pontos. No instrumento foram apresentadas questões sobre a importância, o domínio de competências e seu impacto no desempenho profissional.

Resultados: Os resultados indicam que apenas quatro competências possuem domínio satisfatório por parte dos respondentes, e que cinco competências carecem maior aprimoramento: capacitação continuada, técnicas de investigação de fraudes, redação, conhecimento jurídico e pensar como malfeitor. As competências comportamentais foram consideradas mais importantes do que as técnicas. Ainda assim, algumas competências importantes no contexto internacional tiveram médias baixas no contexto brasileiro.

Contribuições do Estudo: O estudo permite conhecer as competências dos analistas periciais do MPF sob os aspectos de importância, domínio e impacto no desempenho profissional. Os resultados podem ser empregados para o desenvolvimento de ações de capacitação na instituição da amostra bem como para outras instituições que dispõe de quadro semelhante. O estudo também pode ser replicado como diagnóstico para outras instituições e quadros de profissionais de perícia contábil e forense, servindo de parâmetro de comparabilidade.
Resenha do Livro: Auditoria governamental. Silva, M. C., Silva, R. A., & Silva, J. D. G. (2019). (1a ed). São Paulo, SP: Editora Biblioteca 24Horas, 86 páginas, ISBN: 978-85-4161-389-7.
Authors: Edna Maria da Silva Medeiros de Oliveira
Published: January 2020

A resenha tem o objetivo de apresentar uma síntese das ideais fundamentais do livro dos Professor Doutor Maurício Corrêa da Silva, Professor Mestre Romildo Araújo da Silva e Professor Doutor José Dionísio Gomes da Silva, lançado no ano de 2019, pela Editora Biblioteca 24Horas.
PERSPECTIVAS TEÓRICAS SOBRE DESENVOLVIMENTO REGIONAL
Authors: Vasconcelos Lucas Henrique Campos , Antonello Ideni Terezinha
Published: January 2020

O debate sobre o desenvolvimento regional desigual se consolidou como um tema de grande importância na literatura que aborda o crescimento e o desenvolvimento econômico. Teorias foram e são formuladas com a finalidade de explicar e corrigir os desequilíbrios regionais, alcançando influência tanto no âmbito do ambiente acadêmico quanto no das políticas públicas.  A esse respeito, o objetivo deste artigo é apresentar uma síntese de algumas abordagens teóricas que trabalharam, direta ou indiretamente, com o tema, desde as clássicas até às contemporâneas. Para isso, a produção teórica foi divida em três partes, sendo elas: teorias espaciais ou da localização, teorias clássicas de desenvolvimento regional e abordagens recentes de desenvolvimento regional. Destaca-se que essa divisão foi realizada conforme propõe a maioria dos estudiosos da área, visto que as teorias agrupadas possuem linhas de pensamentos e influências semelhantes. Ou seja, não se buscou discorrer as teorias de forma cronológica.
Genistein: Its Role in Breast Cancer Growth and Metastasis
Authors: Mukund Vidya
Published: January 2020

Background:

Genistein being a phytoestrogen imitates the characteristics of estrogen, which can be useful
to treat conditions by reducing the estrogen levels at the time of menopause, osteoporosis and high risk for breast
cancer.

Objective:

The superior binding of genistein to ERβ might help in reducing breast malignancy risk.

Conclusion:

Genistein induces cell cycle arrest, anti-metastatic properties and ultimately affects the breast cancer
cell growth by multiple mechanisms. Genistein-mediated anti-proliferative or anti-growth effects are usually observed
at higher concentrations. These signaling pathways involve the decrease of NF-κB, HIF-1α, VEGF, and an
increase of tumor suppressor p21. This will provide further insight into understanding the biology of transcription
factors NF-κB, and HIF-1α in breast cancer.
The Effects of Lauric Acid on IPEC-J2 Cell Differentiation, Proliferation, and Death
Authors: Yang Yuan , Huang Jin , Li Jianzhong , Yang Huansheng , Yin Yulong
Published: January 2020

Background:

Lauric acid (LA) has antimicrobial effects and the potential to replace
antibiotics in feeds to prevent postweaning diarrhea and increase overall swine productivity. The
effects of lauric acid on the intestinal epithelial cells remain unclear.

Materials and Methods:

This study investigates the effects of LA on pig intestinal epithelial cell line
(IPEC-J2) differentiation, proliferation, and death and explores its underlying mechanisms. It was
found that 0.25-0.1 mM LA promoted IPEC-J2 cell differentiation. At 1 mM or higher concentrations,
it induced IPEC-J2 cell viability decreases, lipid accumulation, cell proliferation inhibition, and cell
apoptosis. The cell death induced did not depend on caspase pathways.

The data demonstrated that LA induced the IPEC-J2 cell autophagy and impaired autophagy flux
and autophagy plays a role in protecting against LA induced-cell death. p38 MAPK inhibitor
SB202190 attenuated LA-reduced IPEC-J2 cell viability. This associated with an increase in
autophagy level and a decrease in lipid accumulations and FABPI levels.

Conclusion:

Conclusion: In summary, LA promoted the IPEC-J2 cell apoptosis depends on the p38 MAPK
pathways and may involve autophagy and TG metabolism regulation.
MicroRNA (miR)-429 Promotes Inflammatory Injury by Targeting Kruppel-like Factor 4 (KLF4) in Neonatal Pneumonia
Authors: Zhang Lan , Yan HuanLi , Wang Huiping , Wang Li , Bai Boling , Ma Yingjun , Tie Yingchun , Xi Zhaoxia
Published: January 2020

Background:

Neonatal pneumonia is a common disease in the neonatal period with a
high incidence and death. This study aimed to investigate the molecular mechanism and effect of
microRNA (miR)-429 in neonatal pneumonia.

Methods:

The peripheral blood was collected from neonatal pneumonia and healthy patients,
respectively. Human lung fibroblast WI-38 cells were treated with lipopolysaccharide (LPS) to
establish neonatal pneumonia cell model. Then, the miR-429 expression was detected by quantitative
real-time polymerase chain reaction (qRT-PCR). In addition, the relationship between miR-
429 and kruppel-like factor 4 (KLF4) was confirmed by dual luciferase reporter assay. Cell viability,
the level of interleukin 6 (IL-6), IL-1β and tumor necrosis factor α (TNF-α) and apoptosis were
measured by Cell Counting Kit-8 (CCK-8), enzyme linked immunosorbent assay (ELISA) and
flow cytometry. Meanwhile, apoptosis and nuclear factor kappa-B (NF-κB) pathway related proteins
expression were analyzed by western blot.

Results:

MiR-429 expression level was increased in neonatal peripheral blood and LPS-stimulated
WI-38 cells. Then, miR-429 overexpression increased apoptosis, the level of IL-6, IL-1β, TNF-α,
Bax and cleaved caspase-3, while reduced cell viability in LPS-stimulated WI-38 cells. Besides,
KLF4 was identified as the target gene of miR-429, and reversed the changes caused by miR-429
overexpression. Finally, miR-429 suppressor down-regulated p-NF-κB level in LPS-stimulated
cells and KLF4 knockdown reversed these reductions.

Conclusion:

MiR-429 promotes inflammatory injury, apoptosis and activates the NF-κB signaling
pathway by targeting KLF4 in neonatal pneumonia, and then these results provide evidence for
clinical diagnosis and treatment for neonatal pneumonia.
Pragmatic Analysis of Dyslipidemia Involvement in Coronary Artery Disease: A Narrative Review
Authors: Mihăilă Romeo-Gabriel
Published: January 2020

Background:

Dyslipidemia is the main factor involved in the occurrence and progression
of coronary artery disease.

Objective:

The research strategy is aimed at analyzing new data on the pathophysiology of dyslipidemia
involvement in coronary artery disease, the modalities of atherogenic risk estimation and
therapeutic advances.

Method:

Scientific articles published in PubMed from January 2017 to February 2018 were
searched using the terms "dyslipidemia" and "ischemic heart disease".

Results:

PCSK9 contributes to the increase in serum levels of low-density lipoprotein-cholesterol
and lipoprotein (a). The inflammation is involved in the progression of hyperlipidemia and atherosclerosis.
Hypercholesterolemia changes the global cardiac gene expression profile and is thus involved
in the increase of oxidative stress, mitochondrial dysfunction, and apoptosis initiated by inflammation.
Coronary artery calcifications may estimate the risk of coronary events. The cardioankle
vascular index evaluates the arterial stiffness and correlates with subclinical coronary atherosclerosis.
The carotid plaque score is superior to carotid intima-media thickness for risk stratification
in patients with familial hypercholesterolemia and both can independently predict coronary artery
disease. The lipoprotein (a) and familial hypercholesterolemia have a synergistic role in predicting
the risk of early onset and severity of coronary atherosclerosis. A decrease in atherosclerotic
coronary plaque progression can be achieved in patients with plasma LDL-cholesterol levels below
70 mg/dL. A highly durable RNA interference therapeutic inhibitor of PCSK9 synthesis could be a
future solution.

Conclusion:

The prophylaxis and treatment of coronary artery disease in a dyslipidemic patient
should be based on a careful assessment of cardio-vascular risk factors and individual metabolic
particularities, so it may be personalized.
Therapeutic Journey of Pyrazolines as EGFR Tyrosine Kinase Inhibitors: An Insight into Structure-Activity Relationship
Authors: Singh Navdeep , Gupta Monika
Published: January 2020

Background:

Pyrazolines are five-membered heterocycles with two adjacent nitrogen atoms
present in the ring and they have attracted many researchers all over the world to assess their potential
therapeutic significance. Pyrazolines are known for their crucial role in numerous diseases like cancer
via various mechanisms. Pyrazoline and its derivatives have been found to have potent anticancer activity
by inhibiting EGFR (Epidermal Growth Factor Receptor Tyrosine Kinase) and other types of RTKs.
Rapid advances in the understanding of cellular signaling by EGFR in normal and malignant cells have
brought to light the EGFR as a selective anticancer target. The review enlists some recently developed
pyrazolines as EGFR tyrosine kinase inhibitor along with their structure-activity relationships.

Methods:

The structure-activity relationship of different pyrazoline derivatives was discussed along
with their epidermal growth factor receptor inhibitory activity. Both review and research articles have
been considered and cited in the paper.

Results:

Pyrazolines have assisted medicinal chemistry by their diverse biological activities which make
them a beneficial scaffold. The structure-activity relationship studies on pyrazolines revealed that the
structural characteristics and different substitutions on pyrazoline ring alter the EGFR inhibitory activity.

Conclusion:

In the present review, pyrazoline derivatives with EGFR kinase inhibitory activity are described
based on their structure-activity relationships based on their structural substitution pattern
around the pyrazoline scaffold.
Densely Dilated Spatial Pooling Convolutional Network Using Benign Loss Functions for Imbalanced Volumetric Prostate Segmentation
Authors: Liu Qiuhua , Fu Min , Jiang Hao , Gong Xinqi
Published: January 2020

Background:

The high incidence rate of prostate disease poses a requirement of accurate early
detection. Magnetic Resonance Imaging (MRI) is one of the main imaging methods used for prostate cancer
detection so far, but it has problems of imbalance and variation in appearance, therefore, automated prostate
segmentation is still challenging.

Objective:

Aiming to accurately segment the prostate from MRI, the focus was on designing a unique network
with benign loss functions.

Methods:

A novel Densely Dilated Spatial Pooling Convolutional Network (DDSP ConNet) in an encoderdecoder
structure, with a unique DDSP block was proposed. By densely combining dilated convolution and
global pooling layers, the DDSP block supplies coarse segmentation results and preserves hierarchical contextual
information. Meanwhile, the DSC and Jaccard loss were adopted to train the DDSP ConNet. And it was proved
theoretically that they have benign properties, including symmetry, continuity, and differentiability on the
parameters of the network.

Results:

Extensive experiments have been conducted to corroborate the effectiveness of the DDSP ConNet with
DSC and Jaccard loss on the MICCAI PROMISE12 challenge dataset. In the test dataset, the DDSP ConNet
achieved a score of 85.78.

Conclusion:

In the conducted experiments, DDSP network with DSC and Jaccard loss outperformed most of
the other competitors on the PROMISE12 dataset. Therefore, it has a better ability to extract hierarchical features
and solve the imbalanced medical image problem.
Ultrasound Assisted Synthesis of 2-Substituted Benzofurans via One-Pot and Sequential Method: Their In Vitro Evaluation
Authors: Rao Bodapati V.D. , Vardhini Suryadevara V. , Kolli Deepti , Rao Mandava V.B. , Pal Manojit
Published: January 2020

Background:

The 2-substituted benzofuran framework has attracted enormous attention due to its
presence in a range of bioactive compounds and natural products. While various methods for the synthesis of 2-
substituted benzofuran derivatives are known, several of them suffer from certain drawbacks.

Objective:

The main objective of this work was to explore a series of 2-(het)aryl substituted benzofurans derivatives
for their cytotoxic properties against cancer cell lines in vitro.

Methods:

In our efforts, we have developed a one-pot synthesis of this class of compounds via sequential C-C
coupling followed by C-Si bond cleavage and subsequent tandem C-C/C-O bond-forming reaction under ultrasound
irradiation. The methodology involved coupling of (trimethylsilyl)acetylene with iodoarenes in the presence
of 10% Pd/C-CuI-PPh3-Et3N in MeOH followed by treating the reaction mixture with K2CO3 in aqueous
MeOH and finally coupling with 2-iodophenol. A variety of 2-substituted benzofurans were synthesized using
this methodology in good yield. All the synthesized compounds were tested in vitro against two cancer cell
lines, e.g. MDAMB-231 and MCF-7 cell lines subsequently against SIRT1.

Results:

The benzofuran derivative 3m showed encouraging growth inhibition of both MDAMB-231 and MCF-
7 cell lines and significant inhibition of SIRT1. The compound 3m also showed a concentration-dependent
increase in the acetylation of p53.

Conclusion:

Our efforts not only accomplished a one-pot and direct access to 2-(het)aryl substituted benzofurans
but also revealed that the benzofuran framework presented here could be a potential template for the
identification of potent inhibitors of SIRT1.
Design and Development of a Hardware Efficient Image Compression Improvement Framework
Authors: Hasanujjaman  , Banerjee Arnab , Biswas Utpal , Naskar Mrinal K.
Published: January 2020

Background:

In the region of image processing, a varied number of methods have already
initiated the concept of data sciences optimization, in which, numerous global researchers have put
their efforts upon the reduction of compression ratio and increment of PSNR. Additionally, the efforts
have also separated into hardware and processing sections, that would help in emerging more prospective
outcomes from the research. In this particular paper, a mystical concept for the image segmentation
has been developed that helps in splitting the image into two different halves’, which is further
termed as the atomic image. In-depth, the separations were done on the bases of even and odd pixels
present within the size of the original image in the spatial domain. Furthermore, by splitting the original
image into an atomic image will reflect an efficient result in experimental data. Additionally, the
time for compression and decompression of the original image with both Quadtree and Huffman is also
processed to receive the higher results observed in the result section. The superiority of the proposed
schemes is further described upon the comparison basis of performances through the conventional
Quadtree decomposition process.

Objective:

The objective of this present work is to find out the minimum resources required to reconstruct
the image after compression.

Method:

The popular method of quadtree decomposition with Huffman encoding used for image
compression.

Results:

The proposed algorithm was implemented on six types of images and got maximum PSNR of
30.12dB for Lena Image and a maximum compression ratio of 25.96 for MRI image.

Conclusion:

Different types of images are tested and a high compression ratio with acceptable PSNR
was obtained.
Anti-carbamylated Protein Antibodies and Serum Level of 14-3-3 Protein for Early Detection of Rheumatoid Arthritis Patient in Correlation with Rheumatoid Factor, Anti-CCP Antibodies, Disease Activity and Joint Damage using High Frequency Musculoskeletal Ultrasound
Authors: Ahmed Sahar A. , Darwish Enas M. , Attya Walaa A. , Samir Mai , Elsayed Mennatallah , Abbas Hoda M. , Hasan Marwa D.
Published: January 2020

Background:

Rheumatoid arthritis (RA) is a common progressive chronic inflammatory autoimmune disease which affects mostly small joints, causing pain, swelling, deformity, and disability. Although progress has been made in exploring RA nature, still there is a lot to know about the disease pathogenesis, diagnosis, and treatment.

Aim of the Work:

To investigate the role of serum anti-carbamylated protein antibodies and 14-3-3η in the diagnosis of RA compared to rheumatoid factor (RF), anti-CCP antibodies, and highfrequency musculoskeletal ultrasound used to assess the disease activity and joint damage.

Methods:

Serum anti-carbamylated protein antibodies and 14-3-3η were measured using ELISA in 61 RA patients and 26 normal controls. RA Disease Activity Score (DAS 28), X-ray and musculoskeletal ultrasound (hands and feet), carotid ultrasound (Intima-Media Thickness IMT) were used in assessing the RA disease.

Results:

Anti-carbamylated protein antibodies were significantly elevated in RA patients 4.5 (4.1- 8.9 U⁄ml) compared to the control 3.2(1.9- 4.3 U⁄ml) (p< 0.001) but 14-3-3η showed no significant difference. There was a significant positive correlation between anti-carbamylated protein antibodies, 14-3-3η levels and disease activity score assessed by DAS 28, increased IMT measured by carotid duplex, total synovitis and total erosion score were assessed by musculoskeletal ultrasound. There was no correlation between RF and anti-CCP antibodies. Anti-carbamylated protein antibodies were found to have 66.7% sensitivity and 85.2% specificity in RA diagnosis, while 14- 3-3η had 51.9% sensitivity and 72.1% specificity.

Conclusion:

Anti-carbamylated protein antibodies and 14-3-3η have a high sensitivity and specificity in RA diagnosis and had a correlation with the disease activity and joint damage.
Modeling and Experiment on Combustion Characteristics for Biomass Rotary Burner
Authors: Jia Guohai , Li Lijun , Dai Li , Gao Zicheng , Li Jiping
Published: January 2020

Background:

A biomass pellet rotary burner was chosen as the research object in order to study the influence of excess air coefficient on the combustion efficiency. The finite element simulation model of biomass rotary burner was established.

Methods:

The computational fluid dynamics software was applied to simulate the combustion characteristics of biomass rotary burner in steady condition and the effects of excess air ratio on pressure field, velocity field and temperature field was analyzed.

Results:

The results show that the flow velocity inside the burner gradually increases with the increase of inlet velocity and the maximum combustion temperature is also appeared in the middle part of the combustion chamber.

Conclusion:

When the excess air coefficient is 1.0 with the secondary air outlet velocity of 4.16 m/s, the maximum temperature of the rotary combustion chamber is 2730K with the secondary air outlet velocity of 6.66 m/s. When the excess air ratio is 1.6, the maximum temperature of the rotary combustion chamber is 2410K. When the air ratio is 2.4, the maximum temperature of the rotary combustion chamber is 2340K with the secondary air outlet velocity of 9.99 m/s. The best excess air coefficient is 1.0. The experimental value of combustion temperature of biomass rotary burner is in good agreement with the simulation results.
Toward Gamified Pain Management Apps: Mobile Application Rating Scale–Based Quality Assessment of Pain-Mentor’s First Prototype Through an Expert Study
Authors: Hoffmann Alexandra , Faust-Christmann Corinna A , Zolynski Gregor , Bleser Gabriele
Published: January 2020

Background

The use of health apps to support the treatment of chronic pain is gaining importance. Most available pain management apps are still lacking in content quality and quantity as their developers neither involve health experts to ensure target group suitability nor use gamification to engage and motivate the user. To close this gap, we aimed to develop a gamified pain management app, Pain-Mentor.

Objective

To determine whether medical professionals would approve of Pain-Mentor’s concept and content, this study aimed to evaluate the quality of the app’s first prototype with experts from the field of chronic pain management and to discover necessary improvements.

Methods

A total of 11 health professionals with a background in chronic pain treatment and 2 mobile health experts participated in this study. Each expert first received a detailed presentation of the app. Afterward, they tested Pain-Mentor and then rated its quality using the mobile application rating scale (MARS) in a semistructured interview.

Results

The experts found the app to be of excellent general (mean 4.54, SD 0.55) and subjective quality (mean 4.57, SD 0.43). The app-specific section was rated as good (mean 4.38, SD 0.75). Overall, the experts approved of the app’s content, namely, pain and stress management techniques, behavior change techniques, and gamification. They believed that the use of gamification in Pain-Mentor positively influences the patients’ motivation and engagement and thus has the potential to promote the learning of pain management techniques. Moreover, applying the MARS in a semistructured interview provided in-depth insight into the ratings and concrete suggestions for improvement.

Conclusions

The experts rated Pain-Mentor to be of excellent quality. It can be concluded that experts perceived the use of gamification in this pain management app in a positive manner. This showed that combining pain management with gamification did not negatively affect the app’s integrity. This study was therefore a promising first step in the development of Pain-Mentor.
Effectiveness of Serious Games to Increase Physical Activity in Children With a Chronic Disease: Systematic Review With Meta-Analysis
Authors: Bossen Daniël , Broekema Aline , Visser Bart , Brons Annette , Timmerman Annieck , van Etten-Jamaludin Faridi , Braam Katja , Engelbert Raoul
Published: January 2020

Background

Physical activity (PA) is important for children with a chronic disease. Serious games may be useful to promote PA levels among these children.

Objective

The primary purpose of this systematic review was to evaluate the effectiveness of serious games on PA levels in children with a chronic disease.

Methods

PubMed, EMBASE, PsycINFO, ERIC, Cochrane Library, and CINAHL were systematically searched for articles published from January 1990 to May 2018. Both randomized controlled trials and controlled clinical trials were included to examine the effects of serious games on PA levels in children with a chronic disease. Two investigators independently assessed the intervention, methods, and methodological quality in all articles using the Cochrane risk of bias tool. Both qualitative and quantitative analyses were performed.

Results

This systematic review included 9 randomized controlled trials (886 participants). In 2 of the studies, significant between-group differences in PA levels in favor of the intervention group were reported. The meta-analysis on PA levels showed a nonsignificant effect on moderate to vigorous PA (measured in minutes per day) between the intervention and control groups (standardized mean difference 0.30, 95% CI –0.15 to 0.75, P=.19). The analysis of body composition resulted in significantly greater reductions in BMI in the intervention group (standardized mean difference –0.24, 95% CI –0.45 to 0.04, P=.02).

Conclusions

This review does not support the hypothesis that serious games improve PA levels in children with a chronic disease. The meta-analysis on body composition showed positive intervention effects with significantly greater reductions in BMI in favor of the intervention group. A high percentage of nonuse was identified in the study of serious games, and little attention was paid to behavior change theories and specific theoretical approaches to enhance PA in serious games. Small sample sizes, large variability between intervention designs, and limited details about the interventions were the main limitations. Future research should determine which strategies enhance the effectiveness of serious games, possibly by incorporating behavior change techniques.
Classification of Health-Related Social Media Posts: Evaluation of Post Content–Classifier Models and Analysis of User Demographics
Authors: Rivas Ryan , Sadah Shouq A , Guo Yuhang , Hristidis Vagelis
Published: January 2020

Background

The increasing volume of health-related social media activity, where users connect, collaborate, and engage, has increased the significance of analyzing how people use health-related social media.

Objective

The aim of this study was to classify the content (eg, posts that share experiences and seek support) of users who write health-related social media posts and study the effect of user demographics on post content.

Methods

We analyzed two different types of health-related social media: (1) health-related online forums—WebMD and DailyStrength—and (2) general online social networks—Twitter and Google+. We identified several categories of post content and built classifiers to automatically detect these categories. These classifiers were used to study the distribution of categories for various demographic groups.

Results

We achieved an accuracy of at least 84% and a balanced accuracy of at least 0.81 for half of the post content categories in our experiments. In addition, 70.04% (4741/6769) of posts by male WebMD users asked for advice, and male users’ WebMD posts were more likely to ask for medical advice than female users’ posts. The majority of posts on DailyStrength shared experiences, regardless of the gender, age group, or location of their authors. Furthermore, health-related posts on Twitter and Google+ were used to share experiences less frequently than posts on WebMD and DailyStrength.

Conclusions

We studied and analyzed the content of health-related social media posts. Our results can guide health advocates and researchers to better target patient populations based on the application type. Given a research question or an outreach goal, our results can be used to choose the best online forums to answer the question or disseminate a message.
Promoting Wellness Through Mobile Health Technology in a College Student Population: Protocol Development and Pilot Study
Authors: Haga Susanne B , Shaw Ryan , Kneifel Charles , Bond Sarah J , Ginsburg Geoffrey S
Published: January 2020

Background

The health and well-being of college students has garnered widespread attention and concern in recent years. At the same time, the expansion and evaluation of digital technologies has grown in recent years for different target populations.

Objective

This protocol aims to describe a pilot feasibility study on wearables to assess student interest and to gather baseline data from college freshmen, for the academic year 2019 to 2020.

Methods

All full-time college freshmen residing in a single residence hall were eligible to participate. Study invitations were sent by post and email 5 weeks prior to move-in. Web-based enrollment and in-person attendance at study orientation sessions were mandatory. We provided the incoming freshmen with a wearable and study app. Wearable data and weekly survey data will be collected through the study app and analyzed. We have collected demographic, enrollment, and attrition data and the number and type of support requests from students.

Results

The planning phase of the WearDuke initiative was completed in 2018 to 2019, and the pilot study was launched in July 2019. Of the 175 students invited, 120 enrolled and 114 started the study; 107 students remained active participants till the end of the fall semester. For Apple Watch participants (the majority of study population), weekly survey completion rates ranged from 70% (74/106) to 96% (95/99).

Conclusions

Halfway through the pilot, we noticed that the initiative has been received positively by the students with minimal attrition. The short- and long-term benefits may be substantial for students, the campus, the utilization of health services, and long-term health.

International Registered Report Identifier (IRRID)

DERR1-10.2196/16474
Plasmonic and Hybrid Whispering Gallery Mode–Based Biosensors: Literature Review (Preprint)
Authors: Manzo Maurizio , Cavazos Omar , Huang Zhenhua , Cai Liping
Published: January 2020

BACKGROUND

The term “plasmonic” describes the relationship between electromagnetic fields and metallic nanostructures. Plasmon-based sensors have been used innovatively to accomplish different biomedical tasks, including detection of cancer. Plasmonic sensors also have been used in biochip applications and biosensors and have the potential to be implemented as implantable point-of-care devices. Many devices and methods discussed in the literature are based on surface plasmon resonance (SPR) and localized SPR (LSPR). However, the mathematical background can be overwhelming for researchers at times.

OBJECTIVE

This review article discusses the theory of SPR, simplifying the underlying physics and bypassing many equations of SPR and LSPR. Moreover, we introduce and discuss the hybrid whispering gallery mode (WGM) sensing theory and its applications.

METHODS

A literature search in ScienceDirect was performed using keywords such as “surface plasmon resonance,” “localized plasmon resonance,” and “whispering gallery mode/plasmonic.” The search results retrieved many articles, among which we selected only those that presented a simple explanation of the SPR phenomena with prominent biomedical examples.

RESULTS

SPR, LSPR, tilted fiber Bragg grating, and hybrid WGM phenomena were explained and examples on biosensing applications were provided.

CONCLUSIONS

This minireview presents an overview of biosensor applications in the field of biomedicine and is intended for researchers interested in starting to work in this field. The review presents the fundamental notions of plasmonic sensors and hybrid WGM sensors, thereby allowing one to get familiar with the terminology and underlying complex formulations of linear and nonlinear optics.
Why do shoelaces become untied: life's mysteries (Preprint)
Authors: Marley Bob
Published: January 2020

BACKGROUND

Mankind has forever been stumped by this strange phenomena.

Well... no longer.

.
.
.

OBJECTIVE

To explain why shoelaces become untied.

METHODS

- Tie your shoelace via method A
- Tie your shoelace via method B
- Observe
- Test
- Record data
- Wait

RESULTS

EUREKA!

CONCLUSIONS

I actually don't know.
Aplikasi Metode Geolistrik Resistivitas Konfigurasi Wenner Untuk Menentukan Struktur Tanah di Halaman Belakang SCC ITS Surabaya (Halaman 1 s.d. 5)
Authors: Sanggra Wijaya Andrias
Published: January 2020

Telah dilakukan penelitian mengenai aplikasi metode geolistrik resistivitas yang bertujuan untuk menentukan stuktur lapisan tanah di halaman belakang SCC ITS Surabaya. Metode yang digunakan dalam penelitian ini adalah metode geolistrik resistivitas konfigurasi Wenner dengan mengambil data sebanyak tiga lintasan dan masing-masing lintasan berjarak 30 meter. Pengolahan data menggunakan metode optimasi least square non linier dengan inversi 2D yang ada pada software Res2Dinv. Dari hasil analisis tiga lintasan diperoleh bahwa struktur lapisan tanah di halaman belakang SCC ITS terdiri atas air tanah dimana nilai resistivitasnya relatif kecil. Lapisan yang mengandung air tanah tersebut berada pada kedalaman 1,35 sampai 1,99m dengan resisitivitas 0,551-2,73 Wm. Selain itu juga terdapat lapisan yang berupa pasir yang bercampur dengan lempung, dan alluvium serta kerikil pada lintasan tiga. Pasir merupakan material batuan yang dapat meloloskan air, namun dengan adanya sisipan lempung maka pada lapisan ini dapat menyimpan air dan mengalirkannya namun dalam jumlah yang terbatas.
Pendugaan Model Sumber Anomali Magnetik Bawah Permukaan di Area Pertambangan Emas Rakyat Desa Paningkaban, Kecamatan Gumelar, Kabupaten Banyumas (Halaman 38 s.d. 42)
Authors: - Sehah , Anom Raharjo Sukmaji , Wibowo Okky
Published: January 2020

Telah dilakukan survei magnetik dan pendugaan model sebaran sumber anomali magnetik bawah permukaan di kawasan pertambangan emas rakyat Desa Paningkaban, Kecamatan Gumelar, Kabupaten Banyumas. Data awal yang diperoleh dalam survei magnetik adalah kuat medan magnetik total. Setelah dilakukan beberapa koreksi dan reduksi diperoleh data anomali magnetik residual. Berdasarkan hasil pemodelan terhadap data anomali magnetik residual menggunakan perangkat lunak Mag2DC for Window pada lintasan AB, diperkirakan ada intrusi batuan beku andesit tekstur porfiritik (c = 0,016 cgs units) sebagai bukti kenaikan larutan hidrotermal. Hasil alterasi hidrotermal diperkirakan terjadi pada batupasir dan breksi andesit (c = 0,00324 cgs units). Sedangkan pada lintasan CD, hasil alterasi hidrotermal terjadi pada batupasir berbutir halus dan breksi andesit (c = 0,00184 cgs units). Berdasarkan hasil interpretasi, potensi emas di daerah penelitian diperkirakan terletak di utara dan selatan lintasan AB, yaitu pada posisi 108°59ʹ45,6ʹʹBT dan 7°24ʹ58,8ʹʹLS dengan kedalaman 36 meter, serta 108°59ʹ46,4ʹʹBT dan 7°25ʹ3,2ʹʹLS dengan kedalaman 113 meter. Selain itu hasil interpretasi juga menunjukkan estimasi potensi emas bagian di barat dan timur lintasan CD, yaitu pada posisi 108°59ʹ45,6ʹʹBT dan 7°24ʹ58,8ʹʹLS dengan kedalaman 113 meter serta 108°59ʹ58,9ʹʹBT dan 7°24ʹ58,7ʹʹLS dengan kedalaman 107 meter.
Analisis Kandungan Senyawa Kimia dan Uji Sifat Magnetik Pasir Besi Pantai Ambal (Halaman 29 s.d. 31)
Authors: - Bilalodin , - Sunardi , Effendy Muhtar
Published: January 2020

Analisis senyawa kimia dan uji sifat magnetic pasir besi telah dilakukan. Tujuan penelitian adalah mengetahui kandungan mineral magnetik dan sifat magnetik  yang terdapat pada pasir besi pantai Ambal. Sampel pasir besi diambil dari  pantai Ambal. Pasir diekstraksi dengan menggunakan magnet permanen untuk memisahkan  pasir magnetik dan non magnetik. Pasir magnetik yang telah dipisahkan dilakukan pengujian jenis kandungan mineral dengan  XRD (X-Ray Diffraction) dan uji sifat magnetiknya dilakukan menggunakan VSM (Vibrating Sample Magnetometer).  Hasil penelitian menunjukkan  jenis mineral magnetik pasir pantai Ambal Kecamatan Mirit Kabupaten Kebumen berbentuk senyawa  Magnetite  (Fe3O4) dan Hematite (Fe2O3). Perhitungan nilai suseptibilitas magnetik sebesar 31,88 x10-6 m3/kg   Berdasarkan nilai permeabilitas relatif yang terhitung, mineral magnetik pasir pantai Ambal kecamatan Mirit Kabupaten Kebumen termasuk kategori feromagnetik.
Analisa Magnetoresistance Berbasis Lapisan Tipis Giant Magnetoresistance (GMR) Pada Nanopartikel Cobalt Ferrite (CoFe2O4) Dilapisi Polyethylen Glicol (PEG)
Authors: Susanti Novi , Suharyadi Edi
Published: January 2020

Telah dilakukan pengukuran magnetoresistance pada lapisan tipis spin valve GMR yang memiliki struktur CoFeB/Cu/CoFe/MnIr dengan memvariasikan ketebalan lapisan barrier Cu (2,2 dan 2,8 nm) dan free layer CoFeB (7 dan 10 nm) menggunakan System Four Point Probe Method (SFPPM) pada medan eksternal 0 600 gauss. Dihasilkan perubahan range resistansi (69,29-71,74) Ω untuk Cu 2,2 nm dan (38,5-40,47) Ω untuk ketebalan Cu 2,8 nm. Pada variasi ketebalan CoFeB dihasilkan perubahan range resistansi untuk ketebalan 7 nm dan 10 nm masing masing adalah (38,74-41,11) Ω dan (69,29-71,74) Ω. Selanjutnya lapisan tipis digunakan sebagai sensor magnetik untuk mendeteksi kehadiran nanopartikel CoFe2O4, CoFe2O4 yang dimodifikasi PEG dan CoFe2O4 termodifikasi PEG yang telah mengikat biomolekul formalin. Terjadi pergeseran nilai resistansi ketika lapisan tipis dilapisi nanopartikel magnetik tersebut. Hal ini menunjukkan bahwa lapisan tipis GMR mampu mendeteksi prilaku spin pada nanopartikel magnetik CoFe2O4.
Influence of PSC Changes in The Upstream Sector From Cost Recovery System into Gross Split Towards The Obligation to Pay Land and Building Tax
Authors: Ikasari Irine Handika
Published: January 2020

AbstractThe scheme of profit sharing contracts has been significantly changed due to the enactment of Ministerial Regulation of Energy and Mineral Resources No. 8/2017 concerning the Gross Split Revenue Sharing Contract on January 16, 2017.This research focused on: First, the relationship between the change of PSC Cost Recovery form to PSC Gross Split with the mechanism of Administration of Land and Building Tax and its addressat; and Second relationship between change of PSC Cost Recovery form PSC Gross Split with procedure of Land and Building Tax calculation at exploration and exploitation stage.IntisariSkema kontrak bagi hasil mengalami perubahan yang sangat signifikan akibat diundangkannya Peraturan Menteri ESDM No. 8/2017 Tentang Kontrak Bagi Hasil Gross Split pada tanggal 16 Januari 2017. Penelitian ini difokuskan pada: Pertama, hubungan antara perubahan bentuk PSC Cost Recovery menjadi PSC Gross Split dengan mekanisme penatausahaan Pajak Bumi dan Bangunan dan addressat-nya; dan Kedua hubungan antara perubahan bentuk PSC Cost Recovery menjadi PSC Gross Split dengan tata cara perhitungan PBB pada tahap eksplorasi dan eksploitasi.
Problema Penyerapan Adat oleh Pengadilan dan Pengaruhnya bagi Pembaruan Hukum Pidana Nasional
Authors: Suhariyanto Budi
Published: January 2020

AbstractThe draft of Penal Code Bill regulates the living law in society as a form of extension of legality principle, but in its elucidation, there is no further sufficient explanation  about the scope and qualifications of such thing. Thus, there have been some concerns regarding the issue of multi-interpretation in the enforcement of adat criminal law. Having a reflection on the reality of the judges’ interpretation in absorbing adat law while deciding the punishment in accordance with the living and developing justice in society, a further and deeper study in jurisprudence is required to reconsider and reformulate the adat criminal law values in the Draft of Criminal Code Bill. IntisariRancangan KUHP mengatur hukum yang hidup dalam masyarakat sebagai bentuk perluasan asas legalitas, tetapi dalam penjelasannya tidak diatur secara definitif tentang ruang lingkup dan kualifikasi yang memadai. Timbul kekhawatiran persoalan multi tafsir dalam penegakan hukum pidana adat. Bercermin dari realitas penafsiran hakim yang selama ini ada dalam menyerap hukum adat saat memutuskan pemidanaan sesuai dengan keadilan yang hidup dan berkembang di masyarakat, maka diperlukan kajian yang lebih mendalam terkait yurisprudensi yang ada sebagai pertimbangan melakukan reorientasi dan reformulasi nilai-nilai hukum pidana adat dalam Rancangan KUHP.
THE ROLE OF FINANCIAL SERVICES AUTHORITY IN THE CONSUMER PROTECTION AMID THE GROWTH OF FINTECH INDUSTRY IN INDONESIA
Authors: Widijantoro Johanes
Published: January 2020

The growth of the financial technology (fintech) industry is a necessity as an effort to make financial services more practical and efficient. On the other hand, consumers of financial services are still low in financial literacy levels, especially in considering various risks that can occur in dealing with the fintech industry. Indonesian Financial Services Authority (OJK) is the body responsible for carrying out the protection of consumers of financial services. This article describes how legal matters in the fintech business, which are actually useful and can encourage financial inclusion, but on the other hand have the potential to harm consumers if they are not properly regulated. Existing related OJK Regulations would be examined and what things should be regulated by the OJK so that consumers of financial services are protected amid the development of fintech, will also be elaborated in this article. This article respectively describes the rationality of consumer protection in the financial services, the dynamics of fintech growth and its problems, and an analysis of the role of OJK in the era of fintech industry.
SIGNIFICANCE OF INNOVATION FOR SUSTAINABLE ECONOMIC AND AGRICULTURAL DEVELOPMENT IN THE REPUBLIC OF SERBIA
Authors: Despotović Danijela , Ristić Lela , Dimitrijević Miloš
Published: January 2020

Since it is not enough just to achieve economic development, we should strive for sustainable development over a longer period and base it on innovation. It is an extremely important factor of economic and sustainable development. It is particularly important to innovate those economic activities that are crucial for sustainable development and where there are comparative advantages. Because of that, the aim of this paper is to prove that innovation is the key to success and achieving sustainable development. The cluster analysis has highlighted innovative leaders and learners. The Republic of Serbia is a country where agriculture is one of the most important economic activities. In terms of agricultural productivity, it not only lags behind innovative leaders, but also behind other countries of Southeast Europe, distinguished as innovative learners. In addition, in terms of innovation in agriculture, it significantly lags behind other economic activities at the national level, so that  special attention should be paid to this issue.
CAUSES OF NEGATIVE ATTITUDES OF STUDENTS OF ELEMENTARY SCHOOL YOUNGER GRADES TOWARDS CAMPINGS
Authors: Miletić Vladimir , Rajković Željko , Branković Dragan
Published: January 2020

The organization of compulsory camping activities for elementary and secondary school students was given as a possibility in the educational system of the Republic of Serbia. The precondition for the implementation of this plan with the regulated legislation, assumes positive attitudes of both parents and students. Because of their nature, attitudes affect human mental functions. The sample in this study consisted of 252 students of the third and fourth grade, five classes per two elementary schools from Belgrade. A survey was used as an instrument of research, with a main goal to discover number of students with a negative attitude towards camping, with explained motives. Results showed that 15.07% of respondents would not like to go camping. Some think that they are not mature enough, they do not like the mentioned activity, and they think that their camping would be boring, while some might be bothered by insects. The most frequent projected fears of possible lodging at the campsite are fears directed towards wild animals, bugs, spiders, snakes, darkness, sudden sounds, loss, and unknown people. All the aforementioned fears, regardless of their type, are united by the fear of the unknown, and as a form of solution it is recommended to confront these "inconveniences" and fears whereby this process achieves gradual neutralization and their disappearance. Conclusion is that all these fears could be eradicated by getting to know the students with details about the organization of camping and the location of the camp.
THE EFFECTS OF PHYSICAL ACTIVITY ON THE BALANCE OF THE ELDERLY
Authors: Živković Dobrica , Karaleić Slađan , Anđelković Ivana , Aksović Nikola
Published: January 2020

Daily physical activity is necessary for good quality of life among the elderly. It usually happens that with the advent of years, the extent of exercise decreases among the elderly, which could have negative effects on their health. It is very important to point out that if the health results allow it, it is never too late to begin with programmed training and physical exercise. If it is carried out under supervision, the possibility of injury is significantly reduced. The subject matter of this research are studies published from 2000 to 2016, which focused on the effects of physical activity on the balance of individuals over the age of 60. The aim of this review is the compilation of the appropriate literature on physical activity, as well as the clarification on whether there are effects of the physical activity on the balance of the elderly. This overview included 24 research papers. The results of this study confirm the positive effect of physical activity on the balance of the elderly. It has been proven that several weeks of a standardized exercise program, based on the increase in joint mobility, cardio-vascular exercise, strengthening the stability of the pelvic region, and proprioceptive exercise can improve balance skills and reduce the perception of pain. For elderly individuals with specific risk factors for falls, the recommendation is specific aquatic exercise programs which will improve balance and strengthen the lower extremities.