bluuebunny/crossref_metadata_2025 huggingface dataset:
A comparison of two techniques of cell block preparation
Authors: Kasichhwa Anita , Shrivastav Shreya , Agrawal Ayushi
Published: May 2019

Background: Cell block technique is a method of preparing cytological material so that it can be processed, sectioned, stained, and viewed as a histology section. The study compared two methods of cell block preparation, plasma-thromboplastin method and collodion bag technique of cell block preparation.

Materials and Methods: Samples were randomly processed by plasma-thromboplastin technique or by collodion bag technique. Hematoxylin/Eosin stained cell block sections were examined and scored scaling from 1 to 3 for cellularity, clarity, nuclear features, cytoplasm, use of ancillary test and recovery of cell-cluster and fragments. Mann-Whitney U test was used for comparing two methods and establishing statistical significance.

Results: The median cellularity score was 2.0 for plasma-thromboplastin and 1.0 for collodion bag. The median morphological preservation score and use of ancillary test score were 2.0 for both of the method while median score for recovery of cell cluster and fragments was 2.0 for collodion bag and 1.0 for plasma-thromboplastin. Statistically, both of the methods had similar results in cell block quality.

The median total score for plasma-thromboplastin and collodion bag were 10.0 and 11.0 respectively. Diagnostic cell blocks were obtained in 46.51% of cell block by plasma-thromboplastin method and 60.52% of cell block by collodion bag method improving the diagnosis over conventional smear in 76.74% and 81.57% respectively.

Conclusions: Cell block by plasma-thromboplastin and collodion bag method are cost effective, useful adjunct to FNA for diagnosis of mass lesion. Both techniques has no significant difference in quality of cell block produced.
Cytohistological correlation of conventional Papanicolaou smears in cervical neoplasia at a tertiary care hospital of Nepal
Authors: Poudel Anuj , Dahal Prahar
Published: May 2019

Background: Conventional Cervical Cytology is the most widely used cervical cancer screening test. The incidence of cervical carcinoma is incredibly high in developing countries due to lack of proper knowledge. The extensive use of cervical screening with Papanicolau smears had considerably increased the detection of precancerous and cancerous lesion of uterine cervix. Study was conducted to evaluate cytohistological correlation and to calculate concordance and discordance of Pap smear in detection of precancerous and cancerous lesions of uterine cervix.

Materials and Methods: A total of 54 samples reported in Pap smear as cervical intraepithelial lesions and suspicious for invasive malignancies were selected and correlated with corresponding histopathological findings. It was an observational study done for a period of 18 months from November 2016 to May 2018 at UCMS-TH. All the statistical evaluation was done by using SPSS version 20.

Results: During the study period 54 cases were evaluated. Atypical Squamous Cell of Undetermined Significance was the common abnormal findings in the Pap smear with frequency of 26 (48.1%). Out of total 54 cases of Pap smears, 30 (55.55%) were concordant while discrepancies occurred in 24(44.44%) cases with cervical biopsy.

Conclusions: The study revealed a good correlation between cervical cytology and cervical biopsy. We also concluded that conventional Pap smear is a cost effective test for the early detection of precancerous and cancerous cervical lesions.
Study of serum lipase level in pregnant woman presenting with nausea and vomiting
Authors: Dhungana Arun , Gautam Pratigyan , Manandhar Rosina , Karki Chanda
Published: May 2019

Background: Hyperemesis gravidarum is a complex condition characterized by excessive nausea and vomiting during pregnancy. It presents with various symptoms which include disturbed nutrition, electrolyte imbalance, ketosis and extreme weight loss. The objective of this study is to compare serum lipase, amylase and glucose in Hyperemesis gravidarum with non-pregnant women.

Materials and methods: A total of 100 subjects among which 50 were nonpregnant women as controls and 50 were women with hyperemesis gravidarum as cases were enrolled in the study. Serum lipase, amylase and glucose levels were estimated in all the subjects.

Results: The levels of mean serum lipase were lesser in cases (23.55 ± 4.91U/L) compared to that in controls (25.45 ± 5.97U/L) with p=0.086. However, the levels of mean serum amylase were higher in cases (76.40 ± 33.86 U/L) compared to that in controls (69.66 ± 16.45U/L) with p= 0.210. Serum amylase activity was raised in 8% of the patients whereas the activity of pancreatic lipase was within normal range. Serum glucose levels were lower in cases (84.72 ± 11.28 mg/dl) than that in controls (87.04 ± 10.65 mg/dl) with p=0.293.

Conclusions: From this study we conclude that lipase activity was statistically insignificant in hyperemesis gravidarum. Therefore, pancreatic activities were less affected by hyperemesis gravidarum. So, this condition needs further exploration regarding biochemical basis to minimize the risk associated with it.
Pseudomembranous colitis
Authors: Pyakurel Devish
Published: May 2019

Pseudomembranous colitis is an inflammatory condition of the colon that is most often a manifestation of Clostridium difficile infection. If laboratory testing and endoscopic finding for Clostridium difficile infection is negative, then other less common etiologies should be sought for to identify the correct diagnosis. Ischemic colitis, inflammatory bowel disease, medications, chemicals, vasculitis, and multiple infectious pathogens are responsible for non-clostridium difficile Pseudomembranous colitis.   Exposure history, chronic medical problems and a current medication list will aid in narrowing the differential diagnosis. Histology varies significantly with underlying etiology and can establish the diagnosis. Treatment is specific to the underlying etiology. The purpose of this review article is to aware clinicians and other healthcare professionals about various etiologies of pseudo membranous colitis along with its histological finding and treatment.
Collection of abstracts of 20th SANCON 2019
Authors: JSAN Society of Anesthesiologists of Nepal
Published: May 2019

This submission is a collection of abstracts of 20th SANCON 2019 for JSAN.
THE STUDY RESULTS OF PRODUCTIVITY AND GRAIN QUALITY OF THE BREEDING LINES OF WINTER SOFT WHEAT IN THE COMPETITIVE VARIETY-TESTING
Authors: Nekrasova О. А. , Podgorny S. V. , Skripka O. V. , Samofalov A. P. , Gromova S. N. , Chernova V. L. , Kravchenko N. S.
Published: May 2019

The article presents the study results of winter soft wheat lines in competitive variety testing according to productivity and grain quality indicators. The study was conducted at the experimental plot of the laboratory of the breeding and seed-growing of winter soft wheat of intensive type in the FSBSI “Agricultural Research Center “Donskoy” in 2016–2018. 47 winter soft wheat samples of competitive variety testing were used as the studied material. The winter soft wheat variety “Ermak” was used as a standard. Over the years of study 23 lines exceeded productivity of the standard variety “Ermak”, the increase ranged from 0.49 to 1.66 t / ha on average. The maximum protein percentage in grain was formed by the samples “1992/16” (13.5%), “1221/16” (13.5%), “1914/16” (13.6%), “1788/16” (13.9%), “2030/16” (14.0%). The lines “1854/16” and “1990/16” combining high yields (11.17–11.30 t/ha) with protein percentage of 12.9–13.2% are of great interest for breeding. The highest content of gluten in the grain (29.3–30.0%) was identified in the samples “1992/16”, “1914/16”, “2030/16”, “1221/16” and “1093/16”. There were identified the lines “1385/16”, “1533/16” and “1862/16”, combining high yields (11.20–11.59 t/ha) and 27.9–29.1% of gluten in grain. The highest value of SDS-sedimentation (66–70 ml) was found in the samples “1093/16”, “1990/16”, “2079/16”, “1533/16” and “1987/16”. The lines “1547/16”, “1385/16”, “1854/16” combined high yields (11.10–11.31 t/ha) with high value of SDS-sedimentation (62–65 ml). The breeding material identified during the research was used for further study and has been involved in hybridization to increase productivity and grain quality.
THE STUDY RESULTS OF MORPHO-BIOLOGICAL TRAITS OF NORTH AMERICAN ALFALFA SAMPLES
Authors: Ignatiev S. A. , Regidin А. А. , Grayzeva T. V. , Goryunov K. N.
Published: May 2019

Alfalfa is the most valuable forage crop spread all over the world. Due to the varietal diversity of alfalfa in the countries of North America, the laboratory of breeding and seed-growing of perennial grasses of the FSBSI “Agricultural Research Center “Donskoy” conducted the experiments over 27 samples of American and Canadian breeding to find genetic sources of economic and biological traits. The field trials were conducted according to generally accepted methods for forage crops in 2016–2018. The area of experimental plots was 1 m2 with double sequence. The period “beginning of spring germination” and “beginning of flowering” were studied depending on the climatic conditions of the year. In 2016 and 2017 spring germination took place in March, and in 2018 it was in the 1-st decade of April. Beginning of flowering in the studied samples ranged from the 3-d decade of May to the 1-st decade of June. On average, over 3 years, the number of days in the period “beginning of spring germination – beginning of flowering” varied from 68 to 73 days. This period of the standard variety was 72 days. The studied samples had this period on 1–4 days shorter, excluding the samples “K-33299” and “K-42249” (73 days). According to the yield of green mass, none of the samples reliably exceeded the standard variety “Rostovskaya 90” (3.29 kg/m2). The studied alfalfa samples formed 1.57–3.5 kg/m2 of green mass. According to the plant foliage amount, the indicators of the studied samples varied from 42 to 49%. The samples “K-33299” and “K-43272” with 49% of foliage amount slightly exceeded the standard variety “Rostovskaya 90” (48%). The hay yield of the studied samples varied from 31 to 40%, “K-43272” formed the smallest indicator (31%), “K-42249” and “K-45715” (40%) produced the largest amount and when the hay productivity of the standard variety was 35%. There have been identified reliable correlations between the yield of green mass and hay, as well as between the yield of green mass and the number of days during the period “beginning of spring germination – beginning of flowering”.
THE ESTIMATION OF WINTER BARLEY VARIETIES ACCORDING TO ECONOMIC-VALUABLE TRAITS IN THE SOUTH OF THE ROSTOV REGION
Authors: Filippov E. G. , Dontsova А. А. , Dontsov D. P.
Published: May 2019

Winter barley is one of the early ripening grain crops. It is the early ripeness combined with high productivity, lesser needs in good growing conditions that determines the great national economic importance of this culture. To increase and stabilize gross yields of winter barley, it is necessary to develop new varieties adapted to the negative environmental factors. The purpose of the study is to identify promising breeding material for winter barley to grow varieties with high agroecological stability and adaptability to local soil and climatic conditions. The studies were conducted in the FSBSI “Agricultural Research Center “Donskoy” in 2015–2018. The objects of research were the commercial varieties “Timofey”, “Yeryoma”, “Vivat”, the new winter barley varieties “Foks 1”, “Marusya”, as well as the promising breeding lines. The weather conditions of 2017 were more favorable compared with those of 2016 and 2018, which allowed producing higher yields. All the studied winter barley varieties, even in the wet conditions of 2017, showed a high resistance to lodging (4–5 points by a 5-point scale). In the spring and summer months of 2018, there was a significant increase in temperature in comparison with that of 2017. In June there were some days with dry wind, and therefore the air humidity dropped to 38% (23% lower than the multiyear average). The analysis of the yield structure showed that in 2016 the winter barley varieties showed higher values of the traits “number of kernels per ear” and “1000-kernel weight”, and “number of productive stems per 1 m2” in 2017. According to a comprehensive estimation, there have been identified the promising winter barley varieties “Marusya”, “Parallelum 1960” and “Parallelum 1962”, which significantly exceeded the standard variety “Timofey” in terms of productivity, and showed complex resistance to leaf diseases. In 2016, the variety “Marusya” was sent to be studied in the State Variety Network of RF through the North Caucasus region.
An Information-Motivation-Behavioural Skills model analysis of young adults’ sexual behaviour patterns and regulatory requirements for sexual consent in Canada
Authors: Shumlich Erin J. , Fisher William A.
Published: May 2019

Sexual consent has been defined as the unambiguous willingness to engage in sexual activity that is expressed or verified by sexual partners. Despite the importance of expression and ascertainment of sexual consent, there is a marked disconnect between required elements of sexual consent in legal provisions and administrative policies, on one hand, and how individuals actually engage in their sexual interactions, on the other. We also lack an integrated theoretical model of factors that contribute to sexual consent expression and ascertainment to employ as a conceptual foundation to guide sexual consent promotion intervention efforts. This article adopts the perspective of the Information-Motivation-Behavioural Skills (IMB) model of sexual health to organize an overview of research concerning how individuals currently engage in what they view as “sexual consent” behaviours and how regulatory bodies conceptualize and regulate sexual consent, with a specific focus on the Canadian setting. According to the IMB model, deficits in consent related to information, motivation, and behavioural skills are responsible for the lack of sexual consent behaviour enactment, and research that identifies such deficits is discussed throughout the paper. The IMB model and the obstacles to sexual consent expression and ascertainment which are identified have implications for sexual assault adjudication, sexual assault prevention education, and sexual consent-related policy. Understanding how and why individuals currently ascertain and express consent is the crucial foundation upon which sexual consent education and regulation must be built.
Assessment of the Methodological Quality of Economic Evaluations: Main Mistakes
Authors: Khachatryan Georgii , Ivakhnenko Oxana , Sura Maria , Avxentyeva Maria
Published: May 2019

Results of the assessment of methodological quality of economic evaluations (EE), submitted to justify the inclusion/exclusion of drugs in the lists of drugs for medical use (list of vital and essential drugs, additional medication supply list and expensive drug list), are given in the article. The study was conducted in 2018 in the FSBI “Center for healthcare quality assessment and control” of the Ministry of Health of the Russian Federation. Assessment was performed based on 12 criteria in accordance with the requirements to the methodological quality of economic evaluations, described in the draft Order of the Government of the Russian Federation, No. 871, and then were approved in the Order of the Government of the Russian Federation, No. 871, state on 20.11.2018. The distribution of EE based on the number of criteria they did not meet, and also the frequency of made mistakes for each criterion are presented. Main reasons for EE not meeting the requirements to methodological quality, prescribed by the Order of the Government of the Russian Federation, No. 871, are analyzed.
PENGEMBANGAN KAPASITAS ORGANISASI LOKAL BINA KELUARGA REMAJA (BKR) NUSA INDAH DALAM PENANGANAN KENAKALAN REMAJA DI DESA CIBIRU WETAN KECAMATAN CILEUNYI KABUPATEN BANDUNG
Authors: Aurina Rany
Published: May 2019

Abstrak  Penelitian ini bertujuan untuk pengembangan kapasitas organisasi lokal Bina Keluarga Remaja (BKR) Nusa Indah dalam penanganan kenakalan remaja di Desa Cibiru Wetan Kecamatan Cileunyi Kabupaten Bandung. Pengembangan kapasitas organisasi BKR memfokuskan pada aspek Komitmen Bersama, Kepemimpinan, Peraturan Organisasi, Kelembagaan, Sumber Daya Manusia (SDM) dan Jaringan Kerja.Pendekatan yang digunakan dalam penelitian ini adalah pendekatan kualitatif dengan design action research. sumber data primer yaitu enam pengurus inti organisasi BKR Nusa Indah dan sumber data sekunder yaitu dokumen-dokumen yang berhubungan dengan organisasi BKR Nusa Indah. Hasil penelitian tindakan ini adalah berkembangnya kapasitas organisasi BKR Nusa Indah dalam penanganan kenakalan remaja. kegiatan pengembangan kapasitas organisasi BKR Nusa Indah tersebut dapat dilihat dari organisasi memiliki komitmen bersama secara tertulis.organisasi BKR Nusa Indah dapat meraencanakan kegiatan-kegiatan yang aktif , inovatif dan produktif terhadap penanganan kenakalan remaja, pengurus dapat memahami tugas dan fungsinya sesuai dengan jabatan dalam struktur organisasi, organisasi memiliki visi dan misi untuk ketercapaian program, organisasi memiliki papan sekertariat sebagai identitas  dan organisasi mampu menjalin kerjasama dengan organisasi-organisasi yang dapat mengembangkan organisasi BKR Nusa Indah seperti PKBM Qomariah dan Dunia Usaha. Berdasarkan hasil model pengembangan kapasitas tersebut dapat memberikan dampak positif terhadap kapasitas organisasi BKR Nusa Indah.  Hal tersebut dapat dilihat bahwa saat ini kapasitas organisasi BKR Nusa Indah sudah dapat berkembang dengan baik dan diharapkan dapat memberikan pengaruh dalam mengurangi angka kenakalan remaja di Desa Cibiru Wetan.  Kata Kunci: Pengembangan Kapasitas, Organisasi Bina Keluarga Remaja (BKR), Kenakalan Remaja
Model Penanganan Perilaku Maladaptif dengan Cognitive behavior Group Therapy pada Remaja Berisiko di Kelurahan Cimahi Kecamatan Cimahi Tengah Kota Cimahi
Authors: Anggreni Hana
Published: May 2019

Abstrak  Penelitian ini bertujuan untuk melihat bagaimana Cognitive behaviour group therapy dapat menurunkan perilaku maladaptif dari dua subjek penelitian yaitu SNS (Lk/14) dan MV (Lk/14). Kedua subjek penelitian merupakan remaja berisiko terhadap perilaku berisiko seperti terlibat geng, kenakalan remaja ataupun penggunaan obat terlarang. Adapun perilaku maladaptif yang dilakukan adalah perilaku merokok dan perilaku memberontak kepada orangtua yang ditandai dengan tidak mematuhi perintah ataupun berbicara kasar kepada orangtua. Peneliti menggunakan pendekatan kuantitatif dengan metode single subject design dengan model A-B-A. Pada setiap fase dilakukan pengamatan melalui pedoman observasi terhadap frekuensi terjadinya target perilaku. serta dilakukan pengukuran melalui kuisioner untuk melihat aspek kognitif, perasaan dan perilaku.Teknik analisa data dilakukan dengan statistik deskriptif melalui analisa visual dalam kondisi. Hasil penelitian ini menunjukkan bahwa CBGT dapat menurunkan perilaku maladaptif pada SNS dan MV. Bila baseline A1 dan A2 dibandingkan maka akan terlihat penurunan frekuensi perilaku.  Kata kunci : remaja berisiko, perilaku maladaptif, cognitive behavior group therapy
Kvaliteta kokošjih jaja iz konvencionalnog i alternativnih sustava proizvodnje
Authors: Keri Ana Marija , Kralik Zlata
Published: May 2019

Cilj ovog rada bio je usporediti kvalitetu jaja iz kaveznog i alternativnih sustava proizvodnje. Napravljena je komparacija kvalitete jaja iz tri sustava držanja: konvencionalnog (obogaćeni kavezi) i dva alternativna sustava proizvodnje (volijere i podni uzgoj na dubokoj stelji). U pokusu su korištene nesilice hibridne linije Isa Brown, koje su bile u 69. tjednu proizvodnje. Nesilice su hranjene komercijalnom krmnom smjesom. Nasumičnim odabirom uzorkovana su jaja za potrebe analize kvalitete i svježine (masa jaja i masa osnovnih dijelova u jajetu, indeks oblika, čvrstoća i debljina ljuske, visina bjelanjka, HJ, boja žumanjka, pH bjelanjka i pH žumanjka). Kvaliteta jaja određena je na ukupno 74 jaja od čega je 27 jaja od nesilica držanih na dubokoj stelji (DS), 25 komada od nesilica držanih u volijerama (VO) i 22 komada jaja od nesilica držanih u obogaćenim kavezima (OK). Analizom rezultata utvrđeno je da sustavi držanja kokoši nesilica ne utječu (P>0,05) na indeks oblika, masu žumanjka i visinu bjelanjka, dok statistički značajan utjecaj imaju na masu jaja, masu bjelanjka i ljuske, debljinu i čvrstoću ljuske, boju žumanjka, HJ, pH bjelanjka i pH žumanjka, udjele osnovnih dijelova u jajima (P<0,05).
Investigation on the relationship Of service Quality on Tourist Satisfaction and Loyalty: Case Study of Ardabil County
Authors: NAGHİZADEH Robab
Published: May 2019

The objective of this study is to investigate tourist᾿ satisfaction of the Ardabil County tourism  Service Quality using KANO model. In this case, Ardabil County was chosen as a distination (Ardabil County covers an area 3810 km2 in the north west of  Iran). In order to assessment of tourist satisfaction of the Ardabil County tourism  Service Quality, using KANO model,Guestionnaire as survey instrument, was used. The validity and reliability of the survey was based on content validity, and Cronbach᾿s Alpha value in SPSS Version 20. In total, 384 by sampling method were  distributed among tourists in the summer. Evaluation of tourist᾿ satisfaction in KANO model also indicated the tourists from One Dimensional with satisfaction coefficient (0.731) are the most satisfaction. Also the least amount of tourists' satisfaction fom Ardabil County tourism  Services Quality is related to Basic needs with satisfaction coefficient (0.337). Moreover, the results signified the Ardabil County tourism Service Quality affect positively and significantly touriists᾿satisfaction. Furthermore, this study is presented the change in strategies investors, attendants and markers to planning for increasing the  tourists satisfaction in the Ardabil County.
RANCANG BANGUN SISTEM INFORMASI PELAYANAN PENUNJANG MEDIS LABORATORIUM DI PUSKESMAS KOPO BANDUNG
Authors: Kusumadiarti Rini Suwartika , Ripandi Rendra
Published: May 2019

Abstract - Progress in the field of health is very rapidly in developing, so many findings are obtained withinformation technology assistance both in the field of organizing hospitals, health centers, treatment anddevelopment research from the health sciences itself. The combination of information technology with theactivities of people who use these technologies, to support operations and management is an informationsystem. This study aims to design and build an information system implementation of laboratory medicalservices in the UPT Kopo Bandung Health Center. Technique of data collection by means of observation,interviews and literature. Software development methods use the waterfall method with Data Flow Diagrams(DFD) as software design. The suggestions given to overcome the problems in the laboratory medical supportsystem are: There needs to be a better development of the system. and need for training for HR who managethis system regarding the use of the application.Keyword : Information System, Laboratory Service, Waterfall, Microsoft Visual Studio 2010Abstrak - Kemajuan dalam bidang kesehatan sangat berkembang dengan begitu pesat, sehingga banyaktemuan-temuan yang didapatkan dengan bantuan teknologi informasi baik dalam bidang pengorganisasianrumah sakit, puskesmas, pengobatan maupun penelitian pengembangan dari ilmu kesehatan itu sendiri.Kombinasi antara teknologi informasi dengan aktivitas orang yang menggunakan teknologi tersebut, untukmendukung operasi dan manajemen adalah sistem informasi. Penelitian ini bertujuan untuk merancang danmembangun implementasi sistem informasi pelayanan enunjang medis laboratorium di UPT Puskesmas KopoBandungTeknik pengumpulan data dengan cara observasi, wawancara dan studi pustaka. Metodepengembangan perangkat lunak menggunakan metode waterfall dengan Data Flow Diagram (DFD) sebagaiperancangan software. Adapun saran yang diberikan untuk mengatasi permasalahan dalam sistem pelayananpenunjang medis laboratorium adalah : Perlu adanya pengembangan sistem ke arah yang lebih baik, Perluadanya pelatihan untuk SDM yang mengelola sistem ini terkait penggunaan aplikasi.Kata Kunci : Sistem Informasi, Pelayanan Laboratorium, Waterfall, Microsoft Visual Studio 2010
the use of integrated frequency ABC/VEN-analysis of application of medicines for the treatment of influenza and its complications in the hospital
Authors: Leleka M. V. , Davtyan L. L. , Zaliska O. M. , Kit S. Yu.
Published: May 2019

The problem of limiting and rational use of funds in the health care system is relevant worldwide. Influenza and acute respiratory viral infections are cause of a lot of discussion about the treatment and prevention of the disease.

The aim of the work ‒ to conduct an analysis of the data of the actual practice of appointment for patients with severe forms of influenza and its complications that were hospitalized at the hospital of the Lviv Regional Infectious Diseases Clinical Hospital.

For the analysis of data of real practice of appointments were included data of 260 medical cards of patients of the Lviv Regional Infectious Clinical Hospital, which were hospitalized in 2016–2017 years with the diagnosis of influenza and SARI. We used statistical methods, real world evidence analysis, integrated frequency ABC/VEN analysis.

The results of the VEN analysis indicate that in this department pharmacotherapy performs according to the current Protocols for medical care. Integrated frequency, VEN and ABC analysis showed that the leader of applications is Reosorbilact (the rate of expenses is 19%, the frequency of applications – 14%, the percentage of patients to whom it was appointed is 85%). Very expensive antibiotic Tigacil followed them, the next medicines in this list – Xylat (a rate of of expenses 10%, a frequency of applications is 5%, a share of patients – 28%). By answering the question about use the funds for important and vitally necessary medication, we can see that the rate of expenses for medicines of category V is 88.99%, it means that there is a rational use of funds. Analyzing the frequency of using the most expensive drugs (the cost of antibiotics is 46% of the total cost of drugs), it would be advisable to study the possibility of replacing it with cheaper counterparts.

In general, pharmacological therapy is clinically and economically viable, but requires further standardization, and the analysis shows possible ways to optimize it, and reminds us how dangerous are the complications of the influenza, and which resources are needed for their treatment.
Investigation of lipophilic substances of the leaves and flowers of spindle tree (Euonymus Europaea L.)
Authors: Vrubel O. R. , Zin A. R. , Antonyuk V. O.
Published: May 2019

Spindle Tree (Euonymus europaea L.) has long been used in folk medicine for the treatment of dermatomycoces and as an antiparasitic and anthelmintic agent. However, with what substances it is associate this activity,  it is not known for certain. In a previous work, a  was developed extracting scheme from the bark of Spindle Tree (Euonymus europaea L.) to obtain water-soluble and lipophilic substances and the composition of the lipophilic fraction was studied using the GC-MS method.

The purpose of this work was to obtain lipophilic substances from the flowers and leaves of Spindle Tree and to compare their chemical composition with the composition of substances obtained from the bark of the plant.

Flowers and leaves were dried in a drying oven at a temperature of 52 °C, after which a fraction of lipophilic substances was obtained by extraction with petroleum ether. This fraction was analyzed using gas chromatography-mass spectrometry (GC-MS). For this, a chromatographic column was used, which was washed with methanol (model NR-5ms, length 30 m, diameter 0.25 mm, filler: 95% dimethylpolysiloxane + 5% diphenylpolysiloxane; carrier gas ‒ helium with a constant flow of 1.5 ml/min) and 6C / MS Agilent Technologies 6890 N / 5975 B mass spectrometer (USA).

The etxtraction by petroleum ether was obtained fraction of lipophilic substances in the amount of 0.83% of the taken weight of dried flowers and 0.62% by weight of dried leaves. In total, 28 compounds were detected in flowers, and 19 in leaves. It was established that flowers and leaves of Spindle Tree, like bark, are characterized by a high content of paraffinic carbohydrates (from C20H42 to C31H64). Their content is higher in flowers (more than 50% of the composition of the fraction), and in leaves and bark ≈ 35%. Steroid and terpene compounds in the lipophilic fractions of the leaves and bark of the plant are respectively 28.26% and 24.32%. Among them quantitatively dominated by freedeen. A rather high content of squalene (2.06%) was found in the leaves of the plant. Among other compounds, a significant proportion of fatty acids and their esters, of which 24.59% by weight of the lipophilic fraction of flowers and 14.74% by weight of the lipophilic fraction of leaves.

An analysis of the results indicates a greater promise for the use in medicine of lipophilic substances of the bark and leaves of Spindle Tree than of flowers.
An influence of the cream with cerium dioxide nanoparticles on some vital signs of rats in the setting of a topical application in a chronic experiment
Authors: Zaychenko G. V. , Pokotylo O. A. , Nikitina N. S.
Published: May 2019

Melanoma and non-melanoma cancers are global healthcare problems nowadays. Ultraviolet (UV) radiation exposure is one of the risk factors of development of these pathologies. An introduction of sunscreen creams with cerium dioxide nanoparticles (CDN) in medical practice will widen the spectrum of measures of prevention of UV-induced injuries, namely, skin malignancies. Development of such products includes the complex of non-clinical studies in the field of safety pharmacology.

The study on an influence of the cream with CDN on some vital signs of rats in the setting of a topical application in a chronic experiment.

Standardized CDN 6–15 nm in size were synthesized in TOV ‘NanoMedTech’, the dermal cream with 0.25% CDN was developed in SSI ‘Institute for Single Crystals’ of NAS of Ukraine. The experiment was carried out on 100 white female Wistar rats. Animals were allocated into 5 groups with 20 rats each: an intact control, an application of the cream with CDN in the doses of 0.1, 0.5, and 1.0 g/kg, an application of a cream base (placebo). The cream with CDN was applied on skin once a day during 6 months. Toxicity was evaluated on the basis of following indices: survivability, overall health and behavior of animals, ingestion of food and water, body mass dynamics, hematological and serum biochemical indices, macroscopic structure and mass coefficients of internal organs.

No mortality, deterioration of overall health, changes in behavior and ingestion of food and water were observed in groups of an application of the cream with CDN; body mass dynamics were positive. There were no critical differences in hematological (hemoglobin; erythrocyte, thrombocyte, leukocyte count; leucogram) and serum biochemical (alanine aminotransferase, aspartate aminotransferase, total protein, albumin, creatinine, glucose, cholesterol, potassium, sodium, phosphorus, chlorides) indices between groups of an application of the cream with CDN and control groups over a period of the experiment. A macroscopic evaluation of condition of internal organs didn’t show any toxic effect of the cream with CDN, and mass coefficients were standard for rats and basically didn’t differ from those in control groups.

The cream with CDN in the doses of 0.1, 0.5, and 1.0 g/kg in the setting of a topical application in rats once a day during 6 months is safe – it doesn’t cause animal mortality, doesn’t influence overall health, behavior of animals, ingestion of food and water, doesn’t contribute to negative body mass dynamics, doesn’t have a negative impact on hematological and serum biochemical indices, and doesn’t alter a macroscopic structure and mass coefficients of internal organs of rats.
EFEKTIFITAS PELATIHAN DASAR FUNGSIONAL PENYULUH PERTANIAN AHLI DI BALAI BESAR PELATIHAN PERTANIAN BINUANG TAHUN 2018
Authors: Wahyudi Soleh , Adhi Ramadhani Kurnia
Published: May 2019

Penelitian ini bertujuan untuk mengetahui efektivitas pelatihan dasar fungsional penyuluh pertanian ahli di BBPP Binuang. Efektifitas pelatihan diukur  dengan melakukan analisis pengaruh tingkat reaksi dan tingkat pembelajaran peserta diklat terhadap tingkat penerapan materi pasca pelatihan. Populasi penelitian ini yaitu peserta pelatihan dasar fungsional penyuluh pertanian Ahli Angkatan II, V, VI, dan VII. Pemilihan responden menggunakan metode purposive sampling  sebanyak 58 orang. Analisis data yang digunakan adalah analisis regresi  linear berganda menggunakan software SPSS.  Hasilnya penelitian ini menyatakan bahwa tingkat reaksi dan tingkat pembelajaran secara parsial dan simultan berpengaruh signifikan terhadap tingkat penerapan. Tingkat reaksi dan tingkat pembelajaran berpengaruh positif terhadap tingkat penerapan dengan pengaruh  sebesar 67,9 %. Pelaksanaan pelatihan dasar fungsional bagi penyuluh pertanian efektif untuk menunjang pelaksanaan tugas para peserta pasca pelatihan.
Orkestra Tong Sampah Pembelajaran: Hubungan Simbiotik Fungsional antara Ajaran Islam dengan Kegiatan Pembelajaran
Authors: Sholihin Anwar
Published: May 2019

To be "educated" today requires mastery of core subjects, 21st century themes, and 21st century skills. To help students achieve skills in 21st century skills, teachers and administrators need an educational support system that strengthens their teaching capacity, leadership and management and both students and educators need a conducive learning environment for satisfying results. In implementing the teaching and learning of Islamic education, Islamic education teachers are seen in the community as the best example or role model that forms people who are moral and pious. This study aims to identify and explain the functional symbiotic relationship between Islamic teachings and learning activities. The conclusions of this paper are the elements described in this section as "21st century student results" (represented by pelangi) are the skills, knowledge, and skills students must master to succeed in work and life in the 21st century. While in Islam the Prophet Muhammad is a person who teaches: 1) by example and example with the principle of "Talkless, Do More", 2) a person who constantly learns. 3) teaching with stories to learn from, 4) teaching with dialogue, practicing thinking and analyzing, 5) teaching with portrayals. If one does not run, the orchestra of the learning trash can is running
Cerdas Saja Tidak Cukup, suatu Kajian Kecerdasan Majemuk (Kecerdasan Qur’ani) Tentang Ulil Albab
Authors: Ismail Isma'il
Published: May 2019

The Qur'an discusses more comprehensive intelligence (syamil). perfect (kamil), and integral (mutakamil). The Qur'an is the Word of God, while the others are only human thoughts which are dominated by scular instincts. just being smart isn't enough, it takes a higher level than just being smart to achieve recognition of the greatness of God and submission to the Creator. This level can be called "ulil albab". This article aims to: describe how the substance of the concept of plural intelligence according to western experts and the concept of multiple intelligences according to the Qur'an and hadith. From the discussion it was concluded that Multiple Intelligence is a theory of multiple intelligences presented by Prof. Howard Gardner whose substance directs us that the potential of our children, especially if associated with intelligence, to understand multiple intelligence is not to make our children become great. However, the concept, at least can help us to understand that our children save tremendous potential that leads to a distance away from the intelligent substance itself that is distancing from understanding, living and practicing Islamic teachings in accordance with the provisions of the Koran and Al-Sunnah. If we as Muslims who feel as ulil albab, then always bite with molars (holding firm) the legacy of the Prophet Muhammad, before referring to other references.
Pendidikan Agama Islam dan Budi Pekerti Melalui Psikodrama Materi Kisah Teladan Luqman Untuk Meningkatkan Rasa Bersyukur Siswa
Authors: Nawawi Syu'aib
Published: May 2019

Imbalances in education indirectly split the personality of children from kindergarten to college. The preferred objectives are the mastery of the material / information, along with the teaching approach being pursued by the target and achievement of the standard. The evaluation system dictates the process, so the accumulative impact that is felt after a person attending many years of education until graduation from the PT for example is, someone who became a scholar, but not a full scholar who is able to think holistically in overcoming real life problems facing him, let alone participate in solving social problems. This study aims to describe the Islamic Religious Education and Character through Psychodrama Luqman role model to Improve the sense of grateful students. This research includes field research and uses a qualitative descriptive approach. The subjects of this study are SDN Mojosari 1 and 2. The time of this study is even semester of academic year 2017/2018. Data collection method in this research is observation. Data analysis of secondary data, searching and organizing systematically transcripts / records of observations and other materials to improve the author's understanding of the case studied and review it as a finding for others. The results of this study are: that different from other techniques, in psychodrama emotional weight is more highlighted than the intellectual weight. The cultivation of gratitude, especially gratitude requires a long process, in the first phase the teacher starts PBM by praying to instill awareness and gratitude for God's greatness, the teacher motivates the students with the initial activities related to the material. students who are motivated to learn something will use a higher cognitive process in learning the material so that the student will better absorb and listen to the material.
Penggunaan Media Sosial dan Aktivitas Fisik pada Remaja Tingkat Sekolah Menengah Pertama (SMP) Tahun 2018
Authors: Waluyo Imam , Dwi S Imas Dwi S , Subu M Arsyad , Djajang Djajang , Slamet S Slamet , Agustino Rinto
Published: May 2019

Users of social networking sites are consistently logged online to communicate and interact with other users. Social networking sites are one of the most popular forms of social media, especially among teenagers, and are an alternative email as a means of instant communication between friends. This study aims to examine the Correlation between social media use with physical activity on junior high school adolescent. The study a futher analysis of previous research data with the 315 sample of Junior High School adolescent, cross sectional metode use, and Data collected using instrumen Social Networking Use Scale and Physical Activity Questionnaire for Adolescent. The result: low user of SNS with 78 student (24.8%), average user of SNS 143 student (45.4%), high user of SNS 81 student (25.7%), extremely high user of SNS 13 student (4.1%), and physical activity low activity 54 student (17.1%), moderate activity 181 student (57.5%), vigorous activity 80 student (25.4%). the results show that corelation between social media use with physical activity corellation weak with r=0.005 stated is weak, statistically it is not significant p= 0.928 (p>0.05). In this study, we found that there is a weak correlation between social media use with physical activity, and statistically it is not significant
Primipara Undergoing Episiotomy had Lower Postpartum Sexual Function
Authors: Irwan Irwan , Lukas Efendi , Abdullah Nusratuddin
Published: May 2019

Objective: To compare postpartum sexual functions between primipara with episiotomy and without episiotomy.

Method: The research was conducted in public service section of Dr. Wahidin Sudiro Husodo hospital and a number of educational hospitals obstetrics and gynecology of Faculty of Medicine of Hasanuddin University, started from February to May 2012. The research evaluated the sexual function of postpartum with episiotomy in 171 primipara, and 150 primipara postpartum without episiotomy. Sexual function was measured by Female Sexual Function Index (FSFI) questionnaire which had been validated in various countries. The research was conducted with cross sectional approach. Samples were withdrawn with consecutive sampling method. The data was processed with SPSS version 17, with chi-square test, and significant level of 0.05.

Result: Indicated that either the episiotomy or non-episiotomy group has undisturbed sexual function score (>28.5), however, higher score was indicated in non-episiotomy group (65.477) compared to the episiotomy group (59.70), (p<0.05).

Conclusion: Primipara with episiotomy and breastfeeding has lower sexual functions compared to the non-breastfeeding group, however, it was statistically insignificant (p>0.05).

Keywords: episiotomy, FSFI, primipara, sexual functions
Skiciranje grafova nekih složenih trigonometrijskih funkcija
Authors: Orlić Bachler Mandi , Marohnić Luka , Dokić Martina
Published: May 2019

U radu se opisuje kako se na elementaran način (bez primjene diferencijalnoga računa, te praktički koristeći samo papir i olovku) mogu skicirati grafovi složenih trigonometrijskih funkcija oblika f(x) = Asin(g(x)) , f(x) = Acos(g(x)) , f(x) = g(x) · sin(ax + b) , f(x) = g(x) · cos(ax + b) , gdje su A realna konstanta, a > 0 i b ∈ [−pi/2, pi/2] realne konstante na nekom segmentu [a, b] ⊂ R, a g(x) polinom drugog stupnja, eksponencijalna ili logaritamska funkcija.
Ispit iz matematike na državnoj maturi post festum
Authors: Bajrović Vinko
Published: May 2019

Iznošenje argumenata koji ukazuju na potrebu ukidanja ispita iz matematike na osnovnoj razini koji se rješava na državnoj maturi. S maturantima se u 12 godina obrazovanja ostvaruje 1120 sati nastave matematike u osnovnoj školi i 420 ili 560 sati u srednjoj školi (ovisno je li se sati odnose na 3 ili 4 sata nastave matematike tjedno), dakle ukupno 1540 ili 1680 sati nastave matematike. Nema potrebe da se elementarnim zadatcima, većinom iz programa matematike osnovne škole ispituje znanje maturanata. Predlaže se jedinstveni ispit matematike na državnoj maturi. Posebno se ukazuje na problem ocjenjivanja ispita iz matematike na državnoj maturi, niske pragove za pojedinu ocjenu (odstupanje od normalne raspodjele). Predlaže se uz ocjenu i evidentiranje postotne rješivosti zadataka. Zabrinjavajuće su ocjene učenika na ispitu iz matematike ostvarene na državnoj maturi školske godine 2017./2018. u ljetnom roku.
The Optimization Management of Combination Research Methods in Improving the Quality of Writing Research Reports
Authors: Nasruddin Nasruddin , Umiyati Hesti , Fadil Kevin Refano
Published: May 2019

Management in writing research reports is a crucial activity for a researcher who wants to publish his research results. The research method is a method used to get results and discussion of research. In this study, the research method was used to explain the characteristics of quantitative, combination and qualitative methods with as many as 12 (twelve) points, and literature studies on the definition of 4 (four). The core of this study discusses management of the philosophical foundation of combination research, the characteristics of quantitative, qualitative and combination methods. Then discussed also the definition of combination methods, the nature of the combination method, variations of combination methods, combination research methods models: combination model or sequential explanatory design, combination model or sequential exploratory design, combination model or concurrent triangulation design and model combination method or concurrent embedded design. By doing this research, it is hoped that it can add insight to the authors of research reports regarding the management of combination research methods.
Management Multivariate Analysis Methods for Variables Measurement in Scientific Papers
Authors: Yulianto Yulianto , Robihaningrum Namira , Elinda Bella Dhea
Published: May 2019

The management of writing a scientific papers we already know has important chapters in the writing. And have a way of choosing in a variety of methods. There are problems in this study, namely the absence of the use of research methods in scientific-rich management. Then one of them is needed by multivariate data analysis management to become one of the methods in writing scientific papers. Multivariate data is data collected from two or more observations by measuring these observations with several characteristics. There are 2 (two) methods in multivariate data, namely dependency and interdependence methods. Dependency analysis functions to explain or predict dependent variables by using two or more independent variables. Focused on the dependency method there are 9 (nine) classifications. It is expected that the multivariate data analysis management can help writers to use scientific research methods well and be able to analyze the influence of several variables on other variables at the same time
Application of Learning Management Using Non-test Instrument to Improve the Quality of Education
Authors: Winarno Winarno , Muhtadi Yudi , Aldiya Much Alvin
Published: May 2019

The quality of education is influenced by many factors in it. These factors include students, school managers, educational environment, quality of education, curriculum, learning materials and so on. A good learning system will produce good quality education, then a good assessment system will encourage teachers to determine good teaching strategies and motivate students to learn better. In connection with that, the learning needs of teachers who are not only able to teach well, but also able to evaluate well. Evaluation is not only based on the assessment of learning outcomes, but also an assessment of input, output and the quality of the learning itself. Research instruments can be interpreted as a tool for collecting research data. Basically the research instrument consisted of tests and non-tests. Non-test instruments are testing instruments in addition to learning achievement tests. Assessment tools that can be used include observation or observation sheets (such as diaries, portfolios, life skills), attitude test instruments, interests, interview techniques, questionnaires, sociometry, case studies, and so on. In the development of non-test instruments that need to be considered are the steps to develop the instrument, the preparation of the non-test instrument grid, and the rules for writing instrument items. In this study will be explained in detail about the preparation of non-test instruments, scoring techniques and also the rules of writing a portfolio.