bluuebunny/crossref_metadata_2025 huggingface dataset:
Vitagenic Effect of Specific Bioactive Fractions of Rhodiola with Trachurus sp. Extract Against Oxidative Stress-Induced Aging in Human Amnion Derived Epithelial Cell Line: In View of a Novel Senolytic
Authors: Marotta Francesco , Thandavan Sathya Priya , Pathak Surajit , Sriramulu Sushmitha , Jothimani Ganesan , Gunasekaran Dharanivasan , Markandeyan Devaprasad , Banerjee Antara
Published: January 2021

Background:

Rhodiola rosea is a herb that has been used in traditional medicine for
several years, and LF is a class of lipoproteins derived from the fish Trachurus sp. (LF-T), which
exhibits known anti-inflammatory activity.

Objective:

Investigating the anti-aging effect of Rhodiola specific bioactive fractions cluster in
combination with LF-T (R-L compound) in H2O2 mediated oxidative stress-induced human amnion
derived epithelial cell line - FL cells as normal human cell line.

Methods:

FL cells were treated with H2O2 to induce cellular aging, followed by treatment of the RL
compound to study its anti-aging characteristics. Based on the proliferation rate, 0.05% and 0.1%
concentration of R-L compound was determined using MTT assay. Anti-aging and anti-oxidant assays,
ABTS, DPPH, Hyaluronidase activity Nitric Oxide, Lipid Peroxidase, and Superoxide Dismutase
were performed. qPCR for anti-aging genes and matrix metalloproteinase genes were analyzed.

Results:

FL cells treated with R-L compound exhibited increased proliferation rate and free-radical
reduction. Decreased Hyaluronidase enzyme activity and regulation of genes such as SIRT1,
KLOTHO, SERPINA 6, MMP 9, and MMP 2 expression depicted the anti-aging role of the R-L
compound. Chemometric profiling of the R-L compound revealed that aromatic compounds and
unsaturated fatty acids along with their derivatives, were present predominantly, which might have
attributed to the potent oxidative stress impeded aging activity.

Conclusion:

Specific Bioactive Fractions of Rhodiola in combination with LF-T obtained from
Trachurus sp. involve in the regulation of aging genes and might be a novel approach to prevent
the cells from oxidative stress damage and also it might avert the aging of cells.
Survival analysis to assess the length of stay of novel coronavirus (COVID-19) patients under Integrated Medicine - Zinc, Vitamin C & Kabasura Kudineer (ZVcKK)
Authors: Nirmala A. , Ravikumar T. , Kanakavalli K. , Pathiban P. , Babu K. , Jamuna D. , Dhanam C. , Sathiyarajeswaran P. , Vinod N. P. , Devi M. S. Shree
Published: January 2021

Objective:

COVID19 pandemic out of all odds has created an opportunity to offer treatment in an integrative
manner. This study measures the Length of stay (LS) of patients in an integrative way, as done earlier in China and Vietnam.
Length of stay, Clinical presentations, and Comorbidities were analyzed among COVID19 patients in ESI Hospital, Coimbatore, Tamil Nadu, India.

Method:

Retrospective cross-sectional data on 251 Positive COVID19 patients of both sexes irrespective of age admitted
from 27 March 2020 and 26 April 2020 cases were included in the study. The final discharge date is taken as 5th May 2020.
Kaplan Meier survival analysis was adopted.

Results:

Male, female ratio were 141(56.2%): 83(33.1%), 12 (4.8%) Male Child and 15 (6.0%) were Female child. 5.2%
of the patients were in the age group greater than 60, 75.3% were in the age group 20-60, and the remaining 19.5% were 0-
20 age group. 84.9% of patients were Asymptomatic, while fever and cough were the main symptoms recorded in the
remaining cases. CT scan was done for 7 patients. No mortality and no serious adverse events were reported. Comorbidity
is 15% and does not influence hospital length of stay. The overall median length of stay is 12 days for those who were under
ZVcKK (Median ST CI- 11.59-12.41).

Conclusion:

This study recorded a median of 12 days in the Length of stay and 13.5 days in the Length of stay average.
Comparing earlier studies, patients taking ZVcKK have savings of 7 days. i.e., the relief speed is higher while using ZVcKK.
An Investigation of the Oil and Gas Geopolitical Situation in the Eastern
Mediterranean Region
Authors: Norouzi Nima
Published: January 2021

:

One of the main global energy struggles in recent years has been in the Eastern Mediterranean.
In cooperation with Egypt and Israel, Greece and the Greek Cypriot government (GCA)
are implementing a containment strategy against Turkey and the Turkish Republic of Northern
Cyprus (TRNC). Turkey’s response to this plan was an exclusive agreement with Libya. Turkey
and Libya have signed a memorandum of national reconciliation on limiting the new continental
shelf’s maritime jurisdiction in the Eastern Mediterranean - the only borders of the shared economic
zone. Greece could act with other countries, and it is said that Turkey’s competence will be ratified
in the face of agreements that may restrict movement. The United States and the European
Union (EU) also sought to share gas with European countries against Turkey, Israel, and the GCA.
This article focuses on Libya’s ongoing competition, given Libya’s oil geopolitics and challenges
in the eastern Mediterranean region. This paper briefly investigates the energy geopolitics in the
eastern Mediterranean and North African regions; this paper aims to conclude the diverse opinions
led by various interests and points of view and suggests a solution for the ever-growing tensions in
this region.
TO THE QUESTION OF LEGAL CONSCIOUSNESS AS AN IDEOLOGICAL SOURCE OF LAW
Authors:   E.K. Dzhamalova Dagestan State University, Dzhamalova E.K. , Ramazanova Z.G. ,   Z.G. Ramazanova Dagestan State University
Published: January 2021

The article explores the relationship between "source of law" and "form of law." It is noted that in modern legal science there is no single approach to this problem. The "ideological" sources of law, which include legal consciousness and legal ideology, are analyzed. It is emphasized that this source of law has not been sufficiently researched. It is concluded that legal awareness and legal ideology are the intellectual basis of the law, capable of streamlining relations between the subjects of law and the role of such phenomena of law as legal awareness, legal culture and the legal ideology is very significant, as they, reflecting spiritual values, are an integral criterion of the legal progress of society and determine the vector of social development. Ideological sources of law are at the heart of legal practice, defining the public importance and expediency of its legal regulation.
KEMAMPUAN GURU MENGIMPLEMENTASIKAN KTSP PADA SD DI KECAMATAN DETUKELI KABUPATEN ENDE
Authors: Dole Ferdinandus Etuasius , Wibowo Udik Budi
Published: January 2021

Penelitian ini bertujuan untuk mendeskripsikan: (1) pemahaman guru tentang KTSP, (2) kemampuan guru mengimplementasikan KTSP, dan (3) ketersediaan faktor penunjang dan faktor penghambat pelaksanaan KTSP pada sekolah dasar di Kecamatan Detukeli. Penelitian ini merupakan penelitian populasi, sehingga semua guru yang menerapkan KTSP menjadi subjek penelitian. Subjek dalam penelitian ini adalah seluruh guru SD di Kecamatan Detukeli yang berjumlah 116 guru. Jenis penelitian yang digunakan adalah penelitian evaluasi diskrepansi, yang datanya dikumpulkan menggunakan angket. Data dianalisis secara deskriptif kuantitatif. Berdasarkan penelitian ini dapat diketahui bahwa pemahaman guru tentang KTSP pada sekolah dasar di Kecamatan Detukeli, Kabupaten Ende masih rendah, dengan skor rata-rata tingkat pemahaman 2,462 (dalam skala lima). Kemampuan guru mengimplementasikan KTSP yang terdiri dari: kemampuan dalam penyusunan silabus dan RPP masih rendah dengan skor rata-rata tingkat kemampuan 2,374. Kemampuan dalam pelaksanaan pem-belajaran masih rendah, dengan skor rata-rata tingkat kemampuan 2,374. Kemampuan melaksanakan evaluasi kegiatan pembelajaran masih rendah, dengan skor rata-rata tingkat kemampuan 2,440. Ketersediaan faktor penunjang pelaksanaan KTSP sangat kurang. Kata kunci: guru, KTSP, implementasi, diskrepansi.
PENINGKATAN KEMAMPUAN MEMBACA INTENSIF MELALUI COOPERATIVE LEARNING TIPE STAD KELAS VI SDN 8 PADANG LAWEH
Authors: Efendi Tasrial , Suhardi Suhardi
Published: January 2021

Tujuan penelitian ini adalah untuk meningkatkan proses pembelajaran dan kemampuan membaca intensif siswa kelas VI SDN 8 Padang Laweh dengan pendekatan kooperatif tipe STAD. Penelitian ini menggunakan desain penelitian tindakan kelas. Penelitian dilaksanakan dalam 2 siklus pada semester I tahun ajaran 2013/2014. Teknik pengumpulan data yang digunakan berupa tes, observasi, dokumentasi, dan catatan lapangan. Hasil penelitian menunjukkan bahwa pendekatan cooperative learning tipe STAD dalam pembelajaran membaca intensif terbukti dapat meningkatkan proses dan hasil pembelajaran membaca intensif siswa. Aktivitas siswa dalam proses pembelajaran dari rata-rata 64,33 pada siklus 1 menjadi 80,67 pada siklus 2 dengan kategori sangat baik. Aktivitas guru dalam proses pembelajaran rata-rata 69,00 dengan kategori baik pada siklus 1 menjadi 83,00 pada siklus 2 dengan kategori sangat baik. Kemampuan membaca intensif siswa mengalami peningkatan, yaitu dari rata-rata 66,33 pada siklus 1 menjadi 80,73 pada siklus 2 dengan kategori sangat baik. Jadi pelaksanaan tindakan menggunakan pendekatan cooperative learning tipe STAD telah mencapai indikator keberhasilan dalam penelitian ini, yakni nilai perolehan rata-rata kemampuan membaca intensif mencapai KKM 70,00 dan ketuntasan belajar klasikal mencapai 80%. _____________________________________________________________________________________________________________________________________ IMPROVING THE INTENSIVE READING ABILITY BY COOPERATIVE LEARNING OF THE STAD TYPE IN GRADE VI SDN 8 PADANG LAWEH ABSTRACT The purpose of this research is to improve the learning process and the intensive reading ability of students of grade VI SDN 8 Padang Laweh through cooperative learning approach of the STAD type. This research used the classroom action research design. This research was done in two cycles in semester 1 of the academic year 2013/2014. The data collection techniques used were test, observation, documentation, and field note. The result shows that the cooperative learning of the STAD type in learning process of intensive reading affects the improvement of the result and process of the intensive reading learning of the students. There is an improvement in students’ activity in the learning process with an average score of 64.33 in the first cycle to become 80.67 in the second cycle or in a very good category. The teacher’s activity in the learning process has an average score of 69.00 or good category in the first cycle and becomes 83.00 in the second cycle, or in a very good category. The intensive reading ability of the students had an average score of 66.33 in the first cycle and became 80.73 in the second cycle or in a very good category. So, the action from cooperative learning approach of STAD type has reached the success indicator in this research, that is the average score of intensive reading ability of 70.00 and the classical mastery of 80%. Keywords: intensive reading ability, learning cooperative of STAD Type
Geogebra: Media Visualisasi Grafis untuk Penyusunan Bahan Ajar
Authors: Dhoruri Atmini , Lestari Dwi , Sari Eminugroho Ratna
Published: January 2021

Menurut beberapa studi dan penelitian menunjukkan bahwa hasil belajar matematika siswa SMP di Indonesia dilihat dari kemampuan kognitif maupun afektif masih tergolong rendah. Kemampuan siswa berusia 15 tahun dalam membaca, matematika, dan sains, hasil yang dicapai siswa Indonesia jauh dari memuaskan. Untuk meningkatkan prestasi belajar siswa diperlukan langkah-langkah penyempurnaan secara mendasar dan konsisten serta sistematik dalam pembelajaran. Salah satu cara yang dilakukan untuk meningkatkan kualitas pembelajaran matematika adalah dengan memanfaatkan Geogebra untuk pembelajaran Matematika. Dua wilayah di Daerah Istimewa Yogyakarta yaitu Kabupaten Sleman dan Bantul masing-masing memiliki kelompok Musyawarah Guru Mata Pelajaran (MGMP) Matematika SMP. Kedua MGMP memiliki permasalahan yang hampir sama atau beririsan yaitu sebagian besar guru belum terampil dalam menyusun bahan ajar matematika dengan bantuan Geogebra. Selain itu kedua MGMP juga belum mengintegrasikan teknologi komputer dalam pembelajaran Matematika. Dalam prakteknya, guru menemui kesulitan untuk memvisualisasikan konsep materi persamaan garis (berupa grafik), kesebangunan, serta bangun datar dan bangun ruang. Pelatihan Geogebra sebagai solusi masalah tersebut, diberikan kepada guru matematika se MGMP Sleman dan Bantul. Pelatihan dilakukan sebanyak 3 pertemuan untuk masing-masing MGMP. Pada awal setiap pertemuan diberikan materi sementara peserta praktek, disetiap akhir pertemuan peserta diberi tugas untuk menyusun bahan ajar. Sebagai evaluasi pelaksanaan kegiatan diberikan angket evaluasi di akhir pertemuan. Berdasarkan angket, sebanyak 100% peserta sangat antusias mengikuti kegiatan workshop Geogebra  ini. Di samping itu, sebesar 37.14% setuju dan 62.86% sangat setuju diadakan pelatihan Geogebra lanjutan. Sementara itu sebanyak 45.71% setuju dan 54.29 % sangat setuju materi workshop sesuai yang dibutuhkan dalam pembelajaran. Keberadaan asisten dirasa sangat membantu, hal ini tampak dari seluruh peserta menyatakan setuju atau sangat setuju. Dari hasil tugas peserta yang dikumpulkan tercatat nilai rata-rata lebih dari 85. Hal ini menunjukkan kemampuan guru menggunakan Geogebra dalam menyiapkan bahan ajar sangat baik.Kata Kunci : Geogebra, visualisasi, matematika
Understanding Gaps Between Daily Living and Clinical Settings in Chronic Disease Management: Qualitative Study
Authors: Ozkaynak Mustafa , Valdez Rupa , Hannah Katia , Woodhouse Gina , Klem Patrick
Published: January 2021

Background

Management of chronic conditions entails numerous activities in both clinical and daily living settings. Activities across these settings interact, creating a high potential for a gap to occur if there is an inconsistency or disconnect between controlled clinical settings and complex daily living environments.

Objective

The aim of this study is to characterize gaps (from the patient’s perspective) between health-related activities across home-based and clinical settings using anticoagulation treatment as an example. The causes, consequences, and mitigation strategies (reported by patients) were identified to understand these gaps. We conceptualized gaps as latent phenomena (ie, a break in continuity).

Methods

Patients (n=39) and providers (n=4) from the anticoagulation clinic of an urban, western mountain health care system were recruited. Data were collected through primary interviews with patients, patient journaling with tablet computers, exit interviews with patients, and provider interviews. Data were analyzed qualitatively using a theory-driven approach and framework method of analysis.

Results

The causes of gaps included clinician recommendations not fitting into patients’ daily routines, recommendations not fitting into patients’ living contexts, and information not transferred across settings. The consequences of these gaps included increased cognitive and physical workload on the patient, poor patient satisfaction, and compromised adherence to the therapy plan. We identified resources and strategies used to overcome these consequences as patient-generated strategies, routines, collaborative management, social environment, and tools and technologies.

Conclusions

Understanding gaps, their consequences, and mitigating strategies can lead to the development of interventions that help narrow these gaps. Such interventions could take the form of collaborative health information technologies, novel patient and clinician education initiatives, and programs that strongly integrate health systems and community resources. Current technologies are insufficient to narrow the gaps between clinical and daily living settings due to the limited number and types of routines that are tracked.
A Privacy-Preserving Log-Rank Test for the Kaplan-Meier Estimator With Secure Multiparty Computation: Algorithm Development and Validation
Authors: von Maltitz Marcel , Ballhausen Hendrik , Kaul David , Fleischmann Daniel F , Niyazi Maximilian , Belka Claus , Carle Georg
Published: January 2021

Background

Patient data is considered particularly sensitive personal data. Privacy regulations strictly govern the use of patient data and restrict their exchange. However, medical research can benefit from multicentric studies in which patient data from different institutions are pooled and evaluated together. Thus, the goals of data utilization and data protection are in conflict. Secure multiparty computation (SMPC) solves this conflict because it allows direct computation on distributed proprietary data—held by different data owners—in a secure way without exchanging private data.

Objective

The objective of this work was to provide a proof-of-principle of secure and privacy-preserving multicentric computation by SMPC with real-patient data over the free internet. A privacy-preserving log-rank test for the Kaplan-Meier estimator was implemented and tested in both an experimental setting and a real-world setting between two university hospitals.

Methods

The domain of survival analysis is particularly relevant in clinical research. For the Kaplan-Meier estimator, we provided a secure version of the log-rank test. It was based on the SMPC realization SPDZ and implemented via the FRESCO framework in Java. The complexity of the algorithm was explored both for synthetic data and for real-patient data in a proof-of-principle over the internet between two clinical institutions located in Munich and Berlin, Germany.

Results

We obtained a functional realization of an SMPC-based log-rank evaluation. This implementation was assessed with respect to performance and scaling behavior. We showed that network latency strongly influences execution time of our solution. Furthermore, we identified a lower bound of 2 Mbit/s for the transmission rate that has to be fulfilled for unimpeded communication. In contrast, performance of the participating parties have comparatively low influence on execution speed, since the peer-side processing is parallelized and the computational time only constitutes 30% to 50% even with optimal network settings. In the real-world setting, our computation between three parties over the internet, processing 100 items each, took approximately 20 minutes.

Conclusions

We showed that SMPC is applicable in the medical domain. A secure version of commonly used evaluation methods for clinical studies is possible with current implementations of SMPC. Furthermore, we infer that its application is practically feasible in terms of execution time.
Emotional Reactions and Likelihood of Response to Questions Designed for a Mental Health Chatbot Among Adolescents: Experimental Study
Authors: Mariamo Audrey , Temcheff Caroline Elizabeth , Léger Pierre-Majorique , Senecal Sylvain , Lau Marianne Alexandra
Published: January 2021

Background

Psychological distress increases across adolescence and has been associated with several important health outcomes with consequences that can extend into adulthood. One type of technological innovation that may serve as a unique intervention for youth experiencing psychological distress is the conversational agent, otherwise known as a chatbot. Further research is needed on the factors that may make mental health chatbots destined for adolescents more appealing and increase the likelihood that adolescents will use them.

Objective

The aim of this study was to assess adolescents’ emotional reactions and likelihood of responding to questions that could be posed by a mental health chatbot. Understanding adolescent preferences and factors that could increase adolescents’ likelihood of responding to chatbot questions could assist in future mental health chatbot design destined for youth.

Methods

We recruited 19 adolescents aged 14 to 17 years to participate in a study with a 2×2×3 within-subjects factorial design. Each participant was sequentially presented with 96 chatbot questions for a duration of 8 seconds per question. Following each presentation, participants were asked to indicate how likely they were to respond to the question, as well as their perceived affective reaction to the question. Demographic data were collected, and an informal debriefing was conducted with each participant.

Results

Participants were an average of 15.3 years old (SD 1.00) and mostly female (11/19, 58%). Logistic regressions showed that the presence of GIFs predicted perceived emotional valence (β=–.40, P<.001), such that questions without GIFs were associated with a negative perceived emotional valence. Question type predicted emotional valence, such that yes/no questions (β=–.23, P=.03) and open-ended questions (β=–.26, P=.01) were associated with a negative perceived emotional valence compared to multiple response choice questions. Question type also predicted the likelihood of response, such that yes/no questions were associated with a lower likelihood of response compared to multiple response choice questions (β=–.24, P=.03) and a higher likelihood of response compared to open-ended questions (β=.54, P<.001).

Conclusions

The findings of this study add to the rapidly growing field of teen-computer interaction and contribute to our understanding of adolescent user experience in their interactions with a mental health chatbot. The insights gained from this study may be of assistance to developers and designers of mental health chatbots.
Variability in Culture-Negative Peritonitis Rates in Pediatric Peritoneal Dialysis Programs in the United States
Authors: Davis T. Keefe , Bryant Kristina A. , Rodean Jonathan , Richardson Troy , Selvarangan Rangaraj , Qin Xuan , Neu Alicia , Warady Bradley A.
Published: January 2021

Background and objectives

International guidelines suggest a target culture-negative peritonitis rate of <15% among patients receiving long-term peritoneal dialysis. Through a pediatric multicenter dialysis collaborative, we identified variable rates of culture-negative peritonitis among participating centers. We sought to evaluate whether specific practices are associated with the variability in culture-negative rates between low– and high–culture-negative rate centers.

Design, setting, participants, & measurements

Thirty-two pediatric dialysis centers within the Standardizing Care to Improve Outcomes in Pediatric End Stage Renal Disease (SCOPE) collaborative contributed prospective peritonitis data between October 1, 2011 and March 30, 2017. Clinical practice and patient characteristics were compared between centers with a ≤20% rate of culture-negative peritonitis (low-rate centers) and centers with a rate >20% (high-rate centers). In addition, centers completed a survey focused on center-specific peritoneal dialysis effluent culture techniques.

Results

During the 5.5 years of observation, 1113 patients had 1301 catheters placed, totaling 19,025 patient months. There were 620 episodes of peritonitis in 378 patients with 411 catheters; cultures were negative in 165 (27%) peritonitis episodes from 125 (33%) patients and 128 (31%) catheters. Low-rate centers more frequently placed catheters with a downward-facing exit site and two cuffs (P<0.001), whereas high-rate centers had more patients perform dialysis themselves without the assistance of an adult care provider (P<0.001). The survey demonstrated that peritoneal dialysis effluent culture techniques were highly variable across centers. No consistent practice or technique helped to differentiate low- and high-rate centers.

Conclusions

Culture-negative peritonitis is a frequent complication of maintenance peritoneal dialysis in children. Despite published recommendations for dialysis effluent collection and culture methods, great variability in culture techniques and procedures exists among individual dialysis programs and respective laboratory processes.
Urbanization and the Development of Informal Activities in the City of Bamenda and Environs, 1988-2010
Authors: Tem Protus Mbeum , Ndambi Milton Abawah
Published: January 2021

Urbanisation has been one of the greatest ingredients for the proliferation of informal activities in developing countries in general and Cameroon in particular. This has been catalysed by increase in population as individuals tussle for economic survival. This is true with the case of the city of Bamenda and environs where informal activities constituted the thrust of economic occupations between 1998 and 2010. With the advent of economic crisis in Cameroon in 1988 and ensuing economic hardship, migrants anticipating for myriad opportunities moved into the area. However, their desires were shattered when they would not find or catchup with their desired dreams. The resultant effect was the quest for informal activities that would provide for their livelihoods and better their standards of living. It is because of this that the study contends that, though the inception of the economic crisis in Cameroon and the budding educational establishments in Bamenda and environs facilitated population growth and urbanisation of the area as well as the proliferation of informal activities, increased crimewaves, unemployment, poor infrastructural development, poor living standards, high cost of transportation and administrative bottlenecks, inadequate finances and the unstable nature of students’ residencies were impedimental to the benefits that goes along with such developments and greatly worked against the advancement of the area.
Formulation and In Vitro Evaluation of Bilayer Tablets of Lansoprazole and Amoxycillin Trihydrate for the Treatment of Peptic Ulcer
Authors: Singh Neha , Pandey Durga , Jain Nilesh , Jain Surendra
Published: January 2021

The present work involves the formulation development, optimization and In-vitro evaluation of bilayer tablet containing Lansoprazole in the immediate release layer and Amoxycillin in the sustained release layer, using sodium starch glycolate as a super disintegrant for the immediate release layer and the hydrophilic matrix HPMC K100M, hydrophobic matrix Ethyl cellulose are used in the sustained release layer. Bilayer tablet showed as initial burst effect to provide dose of immediate release layer Lansoprazole to control the acid secretion level and the sustained release of Amoxycillin for 24 hours. Immediate and sustained release tablets were formulated by wet granulation method because of the poor flow property of the blends. The prepared bilayer tablet was evaluated for their precompression parameters, physical characteristics like hardness, friability, uniformity of weight, uniformity of drug content, swelling index, In-vitro floating studies and In-vitro drug release. The release of the lansoprazole from the immediate release layer was found to be 97.46 ± 0.15% in 15minutes. The release of Amoxycillin Trihydrate for the sustained release floating layer was found to be 98.25 ± 0.14% in 12 hours. Lansoprazole potentiate the effect of Amoxycillin. Hence the bilayer tablets of Lansoprazole and Amoxycillin were used to improve patient compliance towards the effective management of ulcer. Keywords: bilayer tablet, Lansoprazole, and Amoxycillin, sustained release
Respiratory function test data and maximum oxygen consumption of children playing football in a hot and humid environment
Authors: BAZABA KAYILOU Jean Michel , AHOUNOU AΪPE Judith , MOUKOUMBI MABIKA Ghislain Aymard
Published: January 2021

Nowadays, the achievement of a good sporting performance depends on a good development of physical capacities from a young age while respecting the different stages of growth. In spite of this, some football coaches and trainers have no mastery of the principles of training. They subject children to physical effort that does not correspond to the child's developmental stages. In order to evaluate the respiratory function and maximum oxygen consumption of children trained in football, series of test matches were organised by age group under a temperature of 38°C and a humidity of 60%. The results of the study show an increase in maximum oxygen consumption according to age with extremes of 36, 54 ml/min/kg and 55, 99 ml/min/kg. The classification of the values of V ̇O2max according to the spirometry values shows a representativeness of 13-14 year old children in the class of low spirometry values (CV, FEV1 and DEP) and a strong representativeness of 16-17 year old children in the class of high spirometry values (CV, FEV1 and DEP). A correlation exists between maximum oxygen consumption, spirometry equations and anthropometric parameters during the growth of children playing football.  Keywords: Training, children, football, spirometry, Congo (Brazzaville)
Development and Evaluation of Nutritious Supplementary Food Product in Phenyl Hydrazine Induced Anaemia in Wistar Rats
Authors: Hanamghar Dipali , Salokhe Shivani , Tembhurane Sachin , Kolhe Swati
Published: January 2021

Objective- Nutritional deficiency anemia mainly results from a lack of iron, but it also associated due to lack of folate/vitamin B12 and low vitamin C intake. From various studies this is found anemia in people is due to poor eating habits, such as not eating enough fruits and legumes such as beans and peas. Proper nutritional supplementation may be useful in such condition. The aim of the present work was to select a suitable iron rich food material, and prepared a suitable dosage form for management of anaemic condition and to evaluate anti-anaemic potential of nutritious supplementary food. Method- Anemia was induced by phenyl-hydrazine. Animals were treated with nutritious supplementary food throughout the study for 30 days. The haemoglobin concentration was determined after 30 days. Results- Nutritious supplementary food was found to be rich in folic acid, ascorbic acid, and iron. Following the induction of anaemia, the haemoglobin concentration decreased by 30%. Administration of standard hematinic preparation and nutritious supplementary food 2gm/day in divided dose resulted in significant increase (P ≤ 0.05) in haemoglobin concentration when compared to the untreated phenyl hydrazine-induced anaemic rats. Conclusion- Nutritious supplementary food effectively raised the level of haemoglobin. Vitamin and minerals found in nutritious supplementary food are most likely active ingredients responsible for its hematinic effects.
Keywords- Anaemia, nutrition, nutritional anaemia, iron, phenyl hydrazine
Inappropriate shock in Brugada syndrome: incidence and predictors in patients with a subcutaneous implantable cardiac defibrillator
Authors: Casu Gavino , Silva Etelvino , Bisbal Felipe , Viola Graziana , Merella Pierluigi , Lorenzoni Giovanni , Motta Giovanni , Bandino Stefano , Berne Paola
Published: January 2021

Abstract Background: Subcutaneous implantable cardioverter
defibrillators (S-ICDs) avoid complications secondary to transvenous
leads, but inappropriate shocks (ISs) are frequent. Furthermore, IS data
from patients with Brugada syndrome (BrS) with an S-ICD are scarce.
Objective: We aimed to establish the incidence, mechanisms, and
predictors of S-ICD in this population. Methods: We analyzed the
clinical and electrocardiographic characteristics, automated screening
test data, device programming, and IS occurrence in adult patients with
BrS with an S-ICD. Results: Thirty-nine patients were enrolled (69%
male, mean age at diagnosis 46±13 years, mean age at implantation 48±13
years). During a mean follow-up of 26±21 months, 18% patients
experienced IS. Patients with IS were younger at the time of diagnosis
(36±8 versus 48±13 years, p=0.018) and S-ICD implantation (38±9 versus
50±23 years, p=0.019) and presented with spontaneous type 1 Brugada ECG
pattern more frequently at diagnosis or during follow-up (71% versus
25%, p=0.018). During automated screening tests, patients with IS
showed lower QRS voltage in the primary vector in the supine position
(0.58±0.26 versus 1.10±0.35 mV, p=0.011) and lower defibrillator
automated screening score (DASS) in the primary vector in the supine
(123±165 versus 554±390 mV, p=0.005) and standing (162±179 versus
486±388 mV, p=0.038) positions. Age at diagnosis was the only
independent predictor of IS (hazard ratio=0.873, 95% confidence
interval: 0.767-0.992, p=0.037). Conclusion: IS was a frequent
complication in patients with BrS with an S-ICD. Younger age was
independently associated with IS. A more thorough screening process
might help prevent IS in this population.
Are hypotheses necessary in ecology and evolution?
Authors: Betts Matthew , Hadley Adam , Frey David , Frey Sarah , Gannon Dustin , Harris Scott , Kim Hankyu , Leimberger Kara , Moriarty Katy , Northrup Joseph , Phalan Ben , Rousseau Josee , Stokely Thomas , Valente Jonathon J. , Zarrate-Charry Diego
Published: January 2021

Research hypotheses have been a cornerstone of science since before
Galileo. Many have argued that inclusion of multiple hypotheses (1)
encourage discovery of mechanisms, and (2) reduce bias – both features
that should increase transferability and reproducibility. However, we
are entering a new era of big data and highly predictive models where
some argue the hypothesis is outmoded. Indeed, using a detailed
literature analysis, we found prevalence of hypotheses in eco-evo
research is very low (6.7-26%) and static from 1990-2015, a pattern
mirrored in an extensive literature search (N=302,558 articles). Our
literature review also indicates that neither grant success or citation
rates were related to the inclusion of hypotheses, which may provide
disincentive for hypothesis formulation. Here we confront common
justifications for avoiding hypotheses and present new arguments based
on benefits to the individual. Although hypotheses are not always
necessary, we expect their continued and increased use will help our
fields move toward greater understanding, reproducibility, prediction,
and effective conservation of nature.
Epstein--Barr virus positive diffuse large B-cell lymphoma transformed into angioimmunoblastic T-cell lymphoma after treatment
Authors: Wang Chaoyu , Gong YI , Liang Xiping , Chen Rui
Published: January 2021

To date, there is no report on the subsequent development of AITL in
patients with EBV-positive DLBCL. We performed a rare case of
EBV-positive AITL developing one year after initial diagnosis of
EBV-positive DLBCL. The patient showed poor response to the chemotherapy
regimen, and poor surviva
A 5’UTR polymorphism in NT5E gene but not fludarabine systemic exposure influences HCT outcome in patients with high-risk β-thalassemia major
Authors: Pai Aswin , Mohanan Ezhilpavai , Panetta John , Balakrishnan Balaji , Illangeswaran Raveen Stephen , Rajamani Bharathi , Lakshmi Kavitha , Edison Eunice , Korula Anu , A Fouzia , Abraham Aby , George Biju , Srivastava Alok , Mathews Vikram , Balasubramanian Poonkuzhali
Published: January 2021

Aim Although the fludarabine (F-araA)-treosulfan based toxicity reduced
conditioning regimen has improved hematopoietic cell transplantation
(HCT) outcome in patients with high-risk beta-thalassemia major (TM),
rejection and regimen related toxicities (RRT) are still of major
concern. This study aims to assess the role of F-araA pharmacokinetics
(PK) and pharmacogenetics (PG) in a uniform cohort of patients with TM.
Methods All patients with TM who receiving F-araA based regimen prior to
HCT between September 2010 and 2019 were enrolled in this study. F-araA
plasma levels were analyzed using LC-MS/MS. Selected polymorphisms in
genes encoding for the enzymes (NT5E (Ecto-5’-nucleotidase) and DCK
(Deoxycytidine kinase) involved in the metabolism of F-araA were
screened. The influence of F-araA PK and PG on clinical outcomes were
evaluated. Results F-araA PK showed wide inter-individual variation (27
and 19 fold in F-araA AUC and CL) which was explained by a promoter
polymorphism (rs2295890) in the NT5E gene. Patients carrying the NT5E
promoter variant showed no graft rejection (0% vs 7.7%, p=0.07) or
Sinusoidal Obstruction Syndrome (0% Vs 19%, p=0.0007) and a trend to
better EFS (87.5% vs 75.7%, p=0.1). F-araA systemic exposure was not
associated with HCT outcome. Conclusion Our results suggest that the
NT5E promoter polymorphism could be a predictive biomarker in F-araA
based HCT setting in TM, however extensive functional studies are
warranted to validate the clinical utility of this finding.
Global solar radiation prediction model with random forest algorithm
Authors: Kor Hakan
Published: January 2021

Global solar radiation estimation is crucial for regional climate assessment and crop growth. Therefore, studies on the prediction of solar radiation are emerging. With the availability of the public data on solar radiation, computerized models have been developed as well. These predictive models play significant role in determining the potentials of regions suitable for renewable energy generation required by engineering and agricultural activities. Herein a computerized model has been presented for estimating global solar radiation. The model utilizes random forest algorithm and reached predictive value of 93.9%.
The solar eclipse effect on diffusion processes of O+ + O2 → O2+ + O reaction for the upper ionosphere over Kharkov
Authors: Yasar Mehmet
Published: January 2021

The Sun is the most effective factor in determining all processes in the ionosphere. For this reason, examining the effect of solar eclipses on the earth ionosphere provides a very important source of information about sudden and medium-scale changes in the ionosphere structure during a solar eclipse. In this study, the effect of solar eclipse on March 29, 2006 in Kharkov on self-diffusion of O+ + O2 ? O2+ + O reaction was investigated depending on the altitude (202, 252, and 303 km). As a result of the investigation, the minimum value of self-diffusion coefficient was seen at three altitudes on March 29, 2006 at the time of full covering in the solar. Self-diffusion coefficients were found to increase with increasing altitude. The results of the experimental study conducted to examine the effect of the eclipse on the ionosphere using high frequency wave propagation in Turkey where it was seen total eclipse on March 29, 2006 and the result that we obtained in this research are consistent with each other.
Redox status of pregnant women with thrombophilia
Authors: Dimitrijevic Aleksandra , Bradic Jovana , Zivkovic Vladimir , Dimitrijevic Aleksandra , Milojevic-Corbic Mirjana , Djuric Janko , Vasiljevic Dragan , Jakovljevic Vladimir
Published: January 2021

Background/Aim. Since the role of oxidative stress in the pathogenesis of thrombophilia in pregnancy has still not been clarified, the aim of the study was to assess the redox status of pregnant women with thrombophilia. Methods. The study involved 120 pregnant women divided into two groups: pregnant women with thrombophilia (n = 60) and women with normal pregnancy (n = 60). Blood samples for biochemical analysis were collected at the end of the first, second, and third trimester of pregnancy. Concentrations of hydrogen peroxide (H2O2), nitrites (NO2-), and the index of lipid peroxidation measured as thiobarbituric acid reactive substances (TBARS) were measured in plasma. Levels of reduced glutathione (GSH), activities of superoxide dismutase (SOD) and catalase (CAT) were measured in erythrocytes. Results. In women with thrombophilia, NO2- values were increased in the first and third trimester compared to healthy pregnant women (p < 0.05). The higher levels of TBARS and H2O2 were noticed in women with thrombophilia in the first trimester compared to healthy pregnant women (p < 0.05). The values of SOD and CAT were lower in women with thrombophilia in the third and GSH in the first trimester compared to the control group (p < 0.05). Conclusion. Our results suggest an increased generation of prooxidants in thrombophilia at the beginning of gestation, which declines as gestation progresses and reaches similar values as in normal pregnancy at the end of pregnancy. Generally viewed, pregnant women with thrombophilia was associated with impaired antioxidant capacity ? activities of SOD and CAT were lower in the third and GSH in the first trimester compared to their values in healthy pregnant women.
MODEL FOR CAREER GUIDANCE AND PROFESSIONAL SELF-DETERMINATION OF CHILDREN OF DIFFERENT AGE GROUPS BASED ON THE GAMIFICATION PRINCIPLES FOR THE FORMATION OF A DIGITAL FOOTPRINT IN THE CONTINUOUS EDUCATION SYSTEM
Authors: YAKOVLEVA ELENA V. , GOLTSOVA NATALIA V. , VAKHRAMEEV PAVEL S. , IVANOV VLADIMIR V.
Published: January 2021

He article presents a model forcareer guidance and professional self-determination of children of different age groups based on the principles of gamification, including target, meaningful, technological and effective components. The target component includes two types of goals: an overall goal and specific career guidance goals for each age.The The content component is a digital platform designed to record the digital footprint of each participant, which is formed in the process and as a result of developmental career guidance work. The technological component includes a set of game mechanics applied on the digital platform, which allow recording the number of classes attended by each user for each type of profession. The effective component is associated with the understanding of the effectiveness of career guidance and professional self-determination of children in the continuous education process.
ADJECTIVE NEOLOGISMS DERIVED FROM LOAN-WORDSTEMS IN THE MODERN RUSSIAN LANGUAGE
Authors: KOZLOVSKAYA NATALIA V. , PAVLOVA ALINA S.
Published: January 2021

The article deals with the semantic analysis and reveals the peculiarities of the adaptation and functioning of the adjective neologismsderived from a borrowed stemby adding a Russian derivational affix.In the course of the first-stage researchthe thematic classification of the above-mentioned “hybrid” adjectivesis made (the current samplecomprises approximately 200 lexical units).The investigation of the lexical data has shown that the majority of “hybrid” adjectives are derived from English stems and mainly consist of relative adjectives. The article analyses the main derivational patterns in the word-formation of adjectives derived from borrowed nouns and adjectives, and the most productive suffixes are revealed. It is stated that the tendency for adjective derivation from the English stems ending in -ing (the trend which was first observed in the 1990s) has been growing rapidly at the beginning of the 21st century.The analysis of variedlexical data has shown that the functioning of “hybrid” adjectives in the texts different in genre and styleis connected with the phenomenon of variationwhich consists in the difference in root spelling, as well as in the competition between the adjective suffixes. In the concluding part of the article, the authors describe peculiar properties of semantic adaptation which are typical of adjective neologisms derived from loan-word stems.
Modelo de um Memorial justificado, para que possa ser utilizado como ferramenta complementar no ensino e aprendizagem do processo projetual nas disciplinas de Projeto de Arquitetura
Authors: Bassam Luiz Claudio , Antunes Maciel Cilene Maria Lima , Bertoloto José Serafim , Campos Maria das Graças
Published: January 2021

Este artigo trata de um modelo de memorial justificativo que poderá servir de referência para auxiliar os alunos de arquitetura a descreverem e justificarem, de maneira sistemática, as razões para as decisões tomadas e que resultaram em uma solução arquitetônica. Servir de ferramenta complementar no ensino e aprendizagem do processo de projeto nas disciplinas de projeto de arquitetura. A linha de pensamento que orientou o desenvolvimento do memorial teve como base teórica o método desenvolvido por Neves e para a adoção do partido na arquitetura e conceitos abordados por Mahfuz, relacionados ao processo projetual.
A pandemia da produção capitalista do espaço
Authors: Castro Henrique Dorneles de
Published: January 2021

Objetivo: Analisar as possíveis consequências para o espaço urbano brasileiro do isolamento desencadeado pelapandemia do Covid-19, como a adoção do Home Office, o aumento do comércio online e a vilificação da densidadeurbana, a partir da perspectiva de que este não foi um momento de exceção mas sim fruto das relações capitalistas eque, por isso, pode servir para acelerar processos já em voga anteriormente, o que é também momento deoportunidade e dever para abordar e debater questões importantes junto à população que foi forçosamente afetadana prática por processos cuja discussão era limitada à teorização no mundo acadêmico.
KARAKTERISASI RIZOBAKTERI YANG BERPOTENSI MENGENDALIKAN BAKTERI Xanthomonas oryzae pv. oryzae DAN MENINGKATKAN PERTUMBUHAN TANAMAN PADI
Authors: Agustiansyah Agustiansyah , Ilyas Satriyas , Sudarsono Sudarsono , Machmud Muhammad
Published: January 2021

Characterization of rhizobacteri having potential to control Xanthomonas oryzae pv.  oryzae and increase plant growth of rice. Rhizobacteria which are isolated from root could produce HCN, siderophore, and plant growth regulator,  induce systemic resistance, and are increase uptake of plant nutrition  such as phosphate.  The objective of this research was to characterize rhizobacteri  as controling agent for  Xanthomonas oryzae pv.oryzae (Xoo) and as plant growth promoter. The results show that the isolates of P. diminuta A6, P. aeruginosa A54, B.subtilis 11 /C, and B. subtilis  5/B  inhibited the growth of Xoo.  B. subtilis 5/B isolate produced the highest siderophore  activity, followed by of P. aeruginosa A54, P. diminuta A6 and B. subtilis 11/C. Only  P. diminuta A6 isolate  produced HCN. The results also showed that all  rhizobacteri  produced IAA i.e.  B.subtilis 5/B (22.10 µg/ml), B. subtilis 11/C (19.05 µg/ml), P. diminuta A6 (8.68 ug/ml), and  P. aeruginosa A54 (2.95 µg/ml). The content of phosphatase enzyme was as folows B.subtilis 5/B (2.78 units/ ml), B.subtilis 11/C (5.7 units/ml), P. diminuta A6 (2.25 units/ml), and P. aeruginosa A54 (5.71 units / ml). Content of peroxidase enzymes in plants that were treated by using isolates was as follows B.subtilis 5/B (1.30 x 10-3 units/mg protein), P. aeruginosa A6 (1.20 x 10-3 units/mg protein), B.subtilis 11/C (1.15 x 10-3 units/mg protein), and P. aeruginosa A54 (1.05 x 10-3 units/mg protein).
SPESIES PARASITOID LIPAPHIS ERYSIMI ASAL SUMATERA SELATAN DAN VARIASI PARASITISASINYA PADA TUMBUHAN INANG YANG BERBEDA
Authors: Herlinda Siti , Anggraini Erise , Irsan Chandra , Umayah Abu , Thalib Rosdah , Adam Triani
Published: January 2021

Lipaphis erysimi (Hemiptera: Aphididae) is one of the main insect pests on brassicaceous crops. Aphids attack crops by sucking sap from its hosts. Densed population in the initial phase of crop growth could  inhibit growing, loss in yield up to 100%. Experiments were aimed to explore and identify species of  L. erysimi parasitoid in highland areas of South Sumatra, and to  determine potency of the parasitoids to parasitize L. erysimi in laboratory.  The highest parasitism level of L. erysimi (72.40%) was found on 200 aphids which reared on B. juncea.  While, the second highest parasitism level (65.67%) was found on N. indicum.  The number of mummies found on N. indicum was less than on B. juncea.  Of all observations, every treatment  on every tested plant showed that female D. rapae emerged more than male D. rapae (female bias).  The two parasitoids species that parasitized L. erysimi were Diaeretiella rapae and Aphidius sp.  Parasitisation at several location in South Sumatera was highly diverse.  D. rapae was the most abundant parasitoid species on several high lands at South Sumatera.