bluuebunny/crossref_metadata_2025 huggingface dataset:
HPLC – Quality by Design Approach for Simultaneous Detection of Torsemide, Spironolactone and Their Degradant Impurities
Authors: Bihola Unnati , Prajapati Prajesh , Agrawal Y. K.
Published: May 2018

A simple, highly robust (quality by design (QbD) approach), precise and accurate method using high performance liquid chromatography coupled to mass spectrometry has been established for the simultaneous separation, identification and quantitation of a Torsemide (TOR), spironolactone (SPI) and their degradant impurities. The chromatographic separations of drugs and impurities were achieved on a inertsil ODS-3 µm C18, 150 mm × 4.6 mm, while the isocratic elution using a ternary mobile phase mixture of methanol, acetonitrile and water (5:3:2 v/v/v) at a flow rate of 0.2 mL/min was adopted for achieving optimum separations. The quantitation of torsemide and spironolactone was accomplished by UV detection at 254 nm and identification of the degradants were done by comparing identical mass in mass spectrometer. The recoveries of the torsemide and spironolactone were obtained higher than 98 % with good validation parameters; linearity (r2>0.994), LOD and LOQ was 10 and 33 ng for TOR and 75 and 248 ng for SPI respectively. The quality by design (QbD) approach has been successfully utilized to prove the method is robust even deliberate changes in critical parameters.
Textilreste aus einem spätbronzezeitlichen Bergbaurevier bei Radfeld in Nordtirol – Sekundärnutzung von Stoffen zur Abdichtung
Authors: Grömer Karina , Goldenberg Gert , Banck-Burgess Johanna , Gleba Margarita , Hofmann-de Keijzer Regina , Bommel Maarten van , Joosten Ineke , Mehofer Matthias , Nicolussi Kurt , Töchterle Ulrike
Published: May 2018

Im traditionsreichen Bergbaugebiet von Schwaz/Brixlegg im Nordtiroler Unterinntal fand während der späten Bronzezeit und frühen Eisenzeit ein umfangreicher Bergbau auf Kupfererze statt, der zahlreiche Spuren im Gelände hinterlassen hat. Montanarchäologische Forschungsprojekte der Universität Innsbruck, gefördert vom österreichischen Wissenschaftsfonds FWF und vom Tiroler Wissenschaftsfonds TWF, untersuchen seit den 1990er Jahren das prähistorische Montanwesen in diesem Raum. Zu den Forschungszielen gehören die Rekonstruktion der metallurgischen Produktionskette vom Erzabbau über die Aufbereitung bis hin zur Erzverhüttung und Gewinnung von Rohkupfer sowie der Arbeits- und Lebenswelt der prähistorischen Berg- und Hüttenleute. Die bislang prospektierten und in Ausschnitten archäologisch untersuchten Befunde belegen einen zeitlichen Schwerpunkt der Bergbauaktivitäten im 12. bis 8. Jh. v. Chr. Auf einem Verhüttungsplatz bei Radfeld (Mauk A) fanden sich 1997 bei der Freilegung einer „Waschrinne“ zur nassmechanischen Aufbereitung von Schlacken einige gut erhaltene Textilfragmente. Der archäologische Befund sowie die Textilfunde, Analysen zu Textiltechnik, Fasermaterial und Farbstoffen werden im folgenden Beitrag vorgestellt. Zudem werden die funktionelle Interpretation und kulturgeschichtliche Einordnung der Textilfunde diskutiert.
Roman glass and Germanic clay: Ceramic vessels with glass insertions from the Roman- and Germanic Iron Ages in Denmark
Authors: Oldenburger Freerk
Published: May 2018

Der Artikel konzentriert sich auf die Gattung der Fensterurnen bzw. Fenstergefäße, die in Dänemark ausgegraben wurden, aber in einem deutlich größerem Raum verbreitet sind. Das charakteristische Merkmal dieser in der Regel aus Bestattungen geborgenen Gefäßgattung sind eingesetzte Glasfragmente, die genauer betrachtet und analysiert werden. Mit Hilfe der Experimentalarchäologie wird gezeigt, dass die Gefäße verwendungsfähig waren und auch im Alltag genutzt werden konnten. Mögliche Deutungen der Einarbeitung von Glasscherben in Keramikgefäße werden diskutiert.
Associations of pathogenic mutations responsible for breast cancer risk with histology and immunohistochemistry in Romanian population
Authors: Goidescu Iulian Gabriel , Eniu Dan Tudor , Caracostea Gabriela Valentina , Cruciat Gheorghe , Stamatian Florin
Published: May 2018

Introduction: Breast cancer is the most common cancer in women worldwide, and Romania makes no exception from this trend. Genetic screening for Hereditary Breast and Ovarian Cancer began to be used on a larger scale after the introduction of Next Generation Sequencing. The aim of this study was to assess the association of deleterious mutations responsible for breast cancer with histopathological and immunohistochemical prognostic factors and to identify some genetic variants in the BRCA1 and BRCA2 genes. Method: 80 patients with breast cancer and negative genetic test or pathogenic variants on BRCA1/2, TP53, PALB2, CHEK2, ATM genes were included. All the cases had a prior histological diagnosis and complete immunohistochemical features. The genetic testing was conducted through a multigene panel. Results: 65% of patients had a deleterious mutation on BRCA genes. In 97.5% of cases the histology was invasive ductal carcinoma. Significant differences were identified between BRCA1 group and negative mutation group regarding estrogen receptor (ER) (p=0.0051), progesterone receptor (PR) (p=0.0004) and Ki67 (p=0.001). Seven breast cancer patients had BRCA1 c.3607C>T variant, which was statistically significantly associated with triple- negative breast cancer (p <0.0001). Of the 7 cases diagnosed with BRCA 2 mutations we identified the c.8755-1G>A variant in 3 cases and the c.9371A>T variant in 3 cases. Discussion and conclusion: Our study confirmed the association of BRCA1 mutations with negative ER, PR or triple negative breast cancer (TNBC). Description of BRCA1 c.3607C>T mutation for the first time in Romanian population and its association with TNBC will need further investigation.
Perception of External Marketing Communication of Companies by Young Customers
Authors: Rudczuk Adrian
Published: May 2018

External marketing communication of companies is a purposeful process of transferring in -formation to the company’s environment - society, competitors, clients and receiving their feedback.Based on the signals, the company adapts its way of communication. Choosing the most suitabletype of communication may be one of the factors deciding about a company’s success. Even thebest offer would not be able to attract customer’s attention if the information did not reach one.The article combines secondary data - results of the research conducted in Polish compa-nies regarding the use of communication tools, and primary data obtained from own surveys carriedout on students regarding the perception of those tools. The purpose of the article is to evaluate theperception of different communication forms by young customers.
Balance Training Reduces Postural Sway and Improves Sport-specific Performance in Visually Impaired Cross-Country Skiers
Authors: Kurz Alexander , Lauber Benedikt , Franke Steffen , Leukel Christian
Published: May 2018

Kurz, A, Lauber, B, Franke, S, and Leukel, C. Balance training reduces postural sway and improves sport-specific performance in visually impaired cross-country skiers. J Strength Cond Res 35(1): 247–252, 2021—Balance training is highly effective in reducing sport injuries and causes improvements in postural stability and rapid force production. So far, the positive effects of balance training have been described for healthy athletes. In the present experiments, we questioned whether athletes with disabilities of the visual system can also benefit from balance training. Fourteen visually impaired cross-country skiers participated in this randomized controlled study. The intervention group (N = 7) completed 8 sessions of balance training over a period of 4 weeks (2 times per week), whereas a waiting control group (N = 7) received no training during that time. After training, postural sway was significantly reduced in the intervention group but not in the waiting control group. In addition, sport-specific performance, which was assessed by a standardized Cooper's 12-minute test on roller skis or rollerblades, increased in the intervention group. The change in postural sway from the premeasurement to the postmeasurement correlated with the change in sport-specific performance in all subjects. Our results indicate that balance training is useful for improving postural stability and sport-specific performance in visually impaired cross-country skiers. We propose that balance training should therefore be implemented as part of the training routine in athletes with disabilities of the visual system.
A New Mixed Poisson Distribution: Modeling and Applications
Authors: Habibi Mina , Asgharzadeh Akbar
Published: May 2018

In this article, a new mixed Poisson distribution that includes the geometric and negative binomial distributions as special cases is proposed. This distribution is obtained by mixing the Poisson distribution with the binomial exponential 2 distribution. The new distribution is overdispersed (i.e., the variance is greater than the mean), and hence, this distribution is able to incorporate the overdispersion that typically occurs in count data sets. Shape and moments properties of the proposed distribution are discussed. Estimation of the model parameters is considered using the method of moments and maximum likelihood approach. We propose an algorithm for generating random data from the new distribution. Three real data applications are also presented to see that new distribution is useful for modeling count data.
Transducin β-Subunit Can Interact with Multiple G-Protein γ-Subunits to Enable Light Detection by Rod Photoreceptors
Authors: Dexter Paige M. , Lobanova Ekaterina S. , Finkelstein Stella , Spencer William J. , Skiba Nikolai P. , Arshavsky Vadim Y.
Published: May 2018

The heterotrimeric G-protein transducin mediates visual signaling in vertebrate photoreceptor cells. Many aspects of the function of transducin were learned from knock-out mice lacking its individual subunits. Of particular interest is the knockout of its rod-specific γ-subunit (Gγ1). Two studies using independently generated mice documented that this knockout results in a considerable >60-fold reduction in the light sensitivity of affected rods, but provided different interpretations of how the remaining α-subunit (Gαt) mediates phototransduction without its cognate Gβ1γ1-subunit partner. One study found that the light sensitivity reduction matched a corresponding reduction in Gαtcontent in the light-sensing rod outer segments and proposed that Gαtactivation is supported by remaining Gβ1associating with other Gγ subunits naturally expressed in photoreceptors. In contrast, the second study reported the same light sensitivity loss but a much lower, only approximately sixfold, reduction of Gαtand proposed that the light responses of these rods do not require Gβγ at all. To resolve this controversy and elucidate the mechanism driving visual signaling in Gγ1knock-out rods, we analyzed both mouse lines side by side. We first determined that the outer segments of both mice have identical Gαtcontent, which is reduced ∼65-fold from the wild-type (WT) level. We further demonstrated that the remaining Gβ1is present in a complex with endogenous Gγ2and Gγ3subunits and that these complexes exist in wild-type rods as well. Together, these results argue against the idea that Gαtalone supports light responses of Gγ1knock-out rods and suggest that Gβ1γ1is not unique in its ability to mediate vertebrate phototransduction.
Mental Processes of the Main Character in Jhumpa Lahiri’s Interpreter of Maladies
Authors: Isti’anah Arina
Published: May 2018

The study of main characters becomes one of delicate angles to observe in literary work. Instead of the various literary criticisms, linguistics also provides stylistics as the approach to appreciate and interpret literary work, including character analysis. ―Interpreter of Maladies‖ is one of the short stories written by Jhumpa Lahiri which attracts readers‘ attention. Readers may comment the way Lahiri portrays the main character of the story, Mr. Kapasi. To interpret the character‘s feeling in the story, Halliday‘s Functional Linguistics is employed to observe what happens in the character‘s thought. The previous purpose is facilitated by transitivity analysis focusing on the mental process analysis. Transitivity focuses on the clause analysis as the unit which brings meanings, including types of participants in the clause. Halliday divides mental process into four: perceptive, cognitive, emotive, and desiderative. The analysis shows that perceptive, cognitive, and affective dominate the narrator‘s description on Mr. Kapasi, while desiderative appears the least in the main character. The choice of those mental process types signals that Lahiri portrays Mr. Kapasi as an attentive, intellectual, and affectionate character.
Evaluation of Pre-Service English Teachers’ Integration of Educational Technology into their Lesson Plans
Authors: Wahyuni Sri
Published: May 2018

The emergence of technology has shifted so many aspects of people‘ lives including but not limited to the way they interact with each other and accomplish almost all activities. In education context, use of technology has impacted teachers and students‘ interactions both in and outside classroom. For decades now, there has been research on technology use and its‘ benefits on teachers‘ instructional practices and students‘ learning. However, a study specifically looking at the integration of technology into teachers‘ lesson plans is still under research. Therefore, the paper was an attempt to investigate how pre-service English teachers integrated technology in the preparation stage of the instructional activities. The study focused on the evaluation of 22pre-service English teachers‘ lesson plans. It employed a qualitative approach with a document review method. It revealed that the pre-service English teachers have incorporate deducational technology including mobile devices and digital recording. Besides, the most frequently and commonly digital media used were Power Points, audios, videos and online resources downloaded from YouTube. In addition, they made use of communication and collaborative resource such as blogs. Finally, implication for further research is presented
MECHANISMS OF ENDOCRINOLOGY: Cell cycle regulation in adrenocortical carcinoma
Authors: Pereira Sofia S , Monteiro Mariana P , Bourdeau Isabelle , Lacroix André , Pignatelli Duarte
Published: May 2018

Adrenocortical carcinomas (ACCs) are rather rare endocrine tumors that often have a poor prognosis. The reduced survival rate associated with these tumors is due to their aggressive biological behavior, combined with the scarcity of effective treatment options that are currently available. The recent identification of the genomic alterations present in ACC have provided further molecular mechanisms to develop consistent strategies for the diagnosis, prevention of progression and treatment of advanced ACCs. Taken together, molecular and genomic advances could be leading the way to develop personalized medicine in ACCs similarly to similar developments in lung or breast cancers. In this review, we focused our attention to systematically compile and summarize the alterations in the cell cycle regulation that were described so far in ACC as they are known to play a crucial role in cell differentiation and growth. We have divided the analysis according to the major transition phases of the cell cycle, G1 to S and G2 to M. We have analyzed the most extensively studied checkpoints: the p53/Rb1 pathway, CDC2/cyclin B and topoisomerases (TOPs). We reached the conclusion that the most important alterations having a potential application in clinical practice are the ones related to p53/Rb1 and TOP 2. We also present a brief description of on-going clinical trials based on molecular alterations in ACC. The drugs have targeted the insulin-like growth factor receptor 1, TOP 2, polo-like kinase1, cyclin-dependent kinase inhibitors, p53 reactivation and CDC25.
One-Stage Hybrid Procedure for Patent Ductus Arteriosus Combined with Other Cardiac Anomalies in Adults
Authors: Guo HongChang , Wang Yang , Wu Wenhui , Lai Yongqiang
Published: May 2018

Patients with patent ductus arteriosus (PDA) are usually detected and treated during childhood, however, some are not detected until adulthood. In addition, heart failure, severe pulmonary hypertension, and calcification of the ductus may also exist. Transcatheter occlusion has become a widely used technique for the closure of small to moderate sized PDAs since Cambier first reported use of Gianturco coils for transcatheter closure of PDA in 1992 [Cambier 1992]. In the case studies reported here, the one-stage hybrid procedure for PDA combined with other cardiac anomalies in adults was applied with satisfactory results.
„Mintimis išvaikštinėjau kiekvieną lauko rėžį...“: skulptoriaus Juozo Kėdainio egodokumentinis palikimas Kupiškio rajono savivaldybės viešojoje bibliotekoje
Authors: Galvanauskienė Nida
Published: May 2018

[straipsnis ir santrauka lietuvių kalba; santrauka anglų kalba]

Straipsnyje analizuojami Kupiškio r. savivaldybės bibliotekoje saugomi skulptoriaus Juozo Kėdainio (1915–1998) laiškai, siųsti šeimos nariams: nuo 1933 metų adresuoti tėvui Justinui Kėdainiui, vėliau, mirus tėvui, nuo 1951 iki 1996 metų – broliui Broniui Kėdainiui. Laiškai rašyti iš Kauno, Vilniaus, Palangos, Maskvos ir kitų miestų. Skulptoriaus J. Kėdainio laiškai unikalūs savo aprėptimi, nes rašyti daugiau nei 60 metų – nuo XX a. ketvirtojo dešimtmečio Nepriklausomoje Lietuvoje, per kelis sovietmečio dešimtmečius, iki nepriklausomybės atgavimo. Remiantis šiais laiškais atskleidžiamas kultūrinis to meto gyvenimas, santykiai su artimaisiais, meilė gimtajam kraštui, aprašomas darbas Kauno dailės mokykloje, Vilniaus valstybiniame dailės institute (dabar – Vilniaus dailės akademija), kelionės, pasakojama apie kūrybinius sumanymus. Šie laiškai tai ne tik Juozo Kėdainio gyvenimo įvairiaspalvė mozaika, bet ir to laikotarpio Lietuvos gyvenimo liudijimas.
Escenarios visuales para la interpretación gráfica de conceptos
Authors: García Lourdes Pilay
Published: May 2018

El diseño gráfico es una disciplina que promueve el desarrollo creativo de ideas y conceptos, tanto en la práctica académica como en el campo profesional, con el fin de innovar en la comunicación y en la construcción gráfica de un producto final. Sin embargo, uno de los problemas principales de la producción gráfica de una idea es la rapidez con la que se ejecuta la tarea y la escasa intervención del pensamiento lateral para que la obtención de propuestas ilustradas que se destaquen o agreguen valor a un encargo. Para mitigar la dificultad en la producción gráfica de conceptos, se propone entrenar la observación como un punto de partida de la acción gráfica e impulsar el pensamiento lateral como instrumento de búsqueda de nuevas alternativas creativas, a través de la introducción de escenarios visuales. A continuación se presenta un ejercicio realizado con estudiantes de Taller de Diseño Gráfico que permite constatar las tácticas para la producción de un concepto. La actividad evidencia que en la etapa inicial del encargo el grupo grafica rápidamente y los primeros resultados son bocetos commodity del significado. La idea clave del ejercicio es pasar de lo evidente a lo transformacional.
Violence against the Brazilian elderlies: an analysis of hospitalizations
Authors: Castro Vivian Carla de , Rissardo Leidyani Karina , Carreira Lígia
Published: May 2018

ABSTRACT Objective: to identify the prevalence of physical aggression and neglect and abandonment in the hospitalizations of Brazilian elderly people for violence and assault from 2008 to 2013 and the association of these causes with socio-demographic variables related to hospitalization. Method: quantitative, descriptive, cross-sectional study with elderlies hospitalized for assault. Inclusion criteria: to be 60 years old or over, to have been hospitalized in the Unified Health System (SUS) for assault or neglect and abandonment, between 2008 and 2013. The data were collected in February 2016, in Datasus database and descriptive and inferentially, using the Chi-square distribution, in the Epi Info 3.5.4 program. Results: the prevalence of hospitalizations due to assaults and violence prevailed among 60 and 69 years old men in the public sector. For abandonment and neglect, there was a higher prevalence in women, over 80 years old, in the public sector. Conclusion: nurses must be able to identify and prevent violence against the elderly.
Time use by family caregivers of elderly with dementia: an integrative review
Authors: Carvalho Elcyana Bezerra , Neri Anita Liberalesso
Published: May 2018

ABSTRACT Objective: To describe the development of measures used between 1993 and 2016 to evaluate time use by family caregivers of elderly with dementia and to find out the patterns of time use identified in the literature. Method: An integrative review of articles was performed, indexed by the following terms: time use management, family caregiver and elderly. Results: A total of 17 articles were found, of which seven were methodological. Among these seven articles, five were psychometric. The most frequently used measures were self-reporting (matrices, questionnaires and inventories), validated through objective measures of occurrence and duration. Longitudinal, prospective, clinical and correlational studies showed that care time covaries with the receptors’ dependence and that the caregivers’ subjective well-being is more affected by the time restriction to free choice activities than the burden resulting from obligatory activities. Final considerations: Valid self-reporting measures are widely used nowadays and they are considered to be effective to assess the objective and subjective costs of health care for dementia.
Assessment of ulceration risk in diabetic individuals
Authors: Dutra Luz Marina Alfonso , Novaes Maria Rita Carvalho Garbi , Melo Manuela Costa , Veloso Danyelle Lorrane Carneiro , Faustino Dayane Leticia , Sousa Leila Maria Sales
Published: May 2018

ABSTRACT Objective: To identify the risk factors for foot ulceration through the tracing of diabetic peripheral neuropathy and peripheral arterial disease in individuals with type I and II diabetes, who were assisted in reference centers of the Federal District, Brazil. Method: a cross-sectional and analytical study, with the assessment of 117 individuals in outpatient clinics of the Federal District. Continuous variables were compared through Mann-Whitney test, and categorized variables, through Chi-square test for univariate analysis and Logistics regression test for multivariate analysis. Results: painful diabetic peripheral neuropathy was present in 37 (75.5%) of the individuals with neuropathy. Deformities and loss of protective plant sensibility were related to neuropathy (p=0.014 and p=0.001, respectively). Of the 40 (34.2%) individuals in the sample who presented peripheral arterial disease, 26 (65%) presented calcification risk. Conclusion: signs of painful peripheral polyneuropathy, peripheral arterial disease, deformities, loss of protective plantar sensibility, and dry skin were identified as risk factors for ulceration.
Análise comparativa dos principais processos de negócio de empresas do subsetor de edificações da construção civil
Authors: Amarilla Rosemara Santos Deniz , Iarozinski Neto Alfredo
Published: May 2018

Resumo O presente trabalho teve como objetivo principal apresentar o estudo dos processos de negócio de empresas de pequeno porte do subsetor de edificações. A partir do estudo dos processos desenvolveu-se um modelo básico de processos de negócio. Para tanto, utilizou-se o método de estudo de casos múltiplos como técnica principal para identificar os processos comuns entre as empresas estudadas. Participaram deste trabalho cinco empresas do subsetor de edificações da cidade de Curitiba, Paraná, Brasil. Para coletar os dados realizaram-se entrevistas semiestruturadas, análises de documentos e observações diretas in loco. Com base nas informações obtidas desenvolveu-se a modelagem dos processos de negócio utilizando a notação BPMN (Business Process Modeling Notation). Assim, o estudo possibilitou elaborar um modelo básico que apresenta as melhores práticas pautado no modelo PCF (Process Classification Framework), porquanto adequado e compatível com a realidade das organizações que atuam no subsetor de edificações. O framework obtém uma visão única dos processos, apresentando as principais atividades de cada processo de negócio com o intuito de transmitir um único linguajar dentro da empresa.
Cross-cultural validation of the Child Adolescent Teasing Scale for Colombian students
Authors: Ariza Karol Johanna Briñez , Castillo Clara Virginia Caro , Echevarría-Guanilo María Elena , Prado Marta Lenise Do , Kempfer Silvana Silveira
Published: May 2018

ABSTRACT Objective: to carry out the cross-cultural validation of the instrument “Child Adolescent Teasing Scale” for the Colombian student population. Method: methodological study carried out with students aged 8 to 15, from public and private educational institutions in the municipality of Ibagué, Colombia. The form for the characterization of students and the Child Adolescent Teasing Scale were used. Results: the cross-cultural adaptation process was organized in seven steps: comparison of the Spanish version of the instrument with the original English version, back-translation, consensus version, face validity and terminology adjustment by students, face and content validity by experts, assessment committee for the final version, pilot test and reliability. Conclusion: the version adapted to the Spanish spoken in Colombia of the Child Adolescent Teasing Scale (Escala de burlas para niños y adolescentes), which assesses the frequency and distress caused by teasing, showed desirable results in terms of validity and reliability.
Development of a clinical protocol for detection of cervical cancer precursor lesions
Authors: Sousa Deise Maria Do Nascimento , Chagas Ana Carolina Maria Araújo , Vasconcelos Camila Teixeira Moreira , Stein Airton Tetelbom , Oriá Mônica Oliveira Batista
Published: May 2018

ABSTRACT Objective: to develop and validate the content of a clinical protocol aimed at prevention of cervical cancer in primary care. Method: technological research according to the steps: (1) submission of the project to the research ethics committee; (2) bibliographic survey; (3) elaboration of the clinical protocol; and (4) content validation. In the third step, the information was collected through bibliographic research and gynecology specialists were consulted. For the final step, four judges were selected to evaluate the clinical protocol according to AGREE 2. Domains that reached the minimum level of agreement of 75% in the scores were considered validated. Results: the scores obtained in each domain of the instrument were as follows: domain 1 (scope and purpose) = 87.5%; domain 2 (stakeholder involvement) = 83.3%; domain 3 (development rigor) = 79.7%; domain 4 (clarity of presentation) = 76.3%; domain 5 (applicability) = 78.1%; and domain 6 (editorial independence) = 85.4. Conclusion: the clinical protocol proved to be a validated material with scores above the minimum required. The protocol obtained positive recommendations with modifications and went through adjustments in order to make it more effective.
Na correnteza da vida: a descoberta da doença renal crônica
Authors: Xavier Suênia Silva de Mesquita , Germano Raimunda Medeiros , Silva Isabelle Pereira da , Lucena Silvia Kalyma Paiva , Martins Jéssica Martinelli , Costa Isabelle Katherinne Fernandes
Published: May 2018

Reconstruir, a partir da escuta, a trajetória de vida de uma paciente renal crônica em tratamento hemodialítico constitui o objetivo deste artigo. Como procedimento metodológico, trabalhamos com a história oral de vida, utilizando a entrevista como principal instrumento. A análise se pauta nas narrativas da colaboradora, ancorada em estudos que tratam da história oral e da subjetividade humana, com destaque para a resiliência. Foi possível apreender, com sua trajetória de vida, que a superação das dificuldades é um marco da singularidade. Portanto, sua história nos leva a concluir que, apesar das adversidades e do sofrimento, existe no ser humano a força de navegar nas torrentes e conseguir ser feliz.
CARACTERÍSTICAS FÍSICO-QUÍMICAS E ACEITAÇÃO SENSORIAL DE APRESUNTADO COM ADIÇÃO DE FIBRA DE ERVILHA VISANDO REDUÇÃO DE CUSTO
Authors: Polizer Yana Jorge , Pompeu Daniel , Fregonesi Raul Pereira , Hirano Merícia Harumi , Freire Maria Teresa de Alvarenga , Trindade Marco Antonio
Published: May 2018

Resumo O objetivo deste trabalho foi desenvolver e avaliar as características físico-químicas e sensoriais de apresuntado adicionado de fibra de ervilha como substituto parcial de carne visando redução de custos. Foram processadas duas formulações: Controle - semelhante à formulação comercial e Fibra/Menos Carne (FMC) - redução de 5% de carne e adição de 1% de fibra de ervilha mais 4% de água. Após o processamento, os produtos foram caracterizados quanto a pH, perfil de textura, cor objetiva, perdas por gotejamento, composição centesimal e avaliação sensorial (teste de aceitação com escala hedônica de nove pontos). Na análise do perfil de textura, os parâmetros dureza e mastigabilidade foram maiores (p<0,05) na formulação Controle. A formulação FMC apresentou valor de L* superior (p<0,05) e valores de a* e b* inferiores (p<0,05) ao tratamento Controle. Quanto à avaliação sensorial, os atributos aroma, aparência, textura e sabor não apresentaram diferenças (p>0,05). Já em relação à aceitação geral as formulações diferiram (p<0,05), sendo que FMC apresentou maior aceitabilidade em comparação ao Controle. Conclui-se que é possível utilizar a fibra de ervilha em apresuntado substituindo parcialmente a carne, gerando um produto com boa aceitação sensorial e menores custos.
ILLEGAL ANIMAL-ORIGIN PRODUCTS SEIZED IN BAGGAGE FROM INTERNATIONAL FLIGHTS AT SAO PAULO GUARULHOS AIRPORT (GRU / SBGR), BRAZIL
Authors: Melo Cristiano Barros de , Belo Bruno Benin , Sá Marcos Eielson Pinheiro de , McManus Concepta Margareth , Seixas Luiza
Published: May 2018

Abstract Air transportation is one of the most important means to introduce illegally imported animal-origin products into a country. Studies have demonstrated that these items pose a risk of disseminating diseases. São Paulo Guarulhos International Airport (GRU / SBGR) is the main international airport in Brazil in terms of people movement and it has the largest number of seizures of animal-origin products. The aim of the present work was to describe the dynamics of the seizure of illegally imported animal-origin products in baggage from international flight passengers at GRU / SBGR Airport in Brazil. Five hundred and eighty-nine different flights from 43 airlines, arriving from 117 countries were analyzed between 2006 and 2009. The total number of seized items increased from 2006 to 2009 and a single flight from France had the highest number of seizures, followed by flights from South Africa and Germany. Countries were grouped into regions or continents to facilitate the analysis. This grouping was based on historical and cultural ties rather than geographical aspects. Seafood was the most frequently seized product, followed by dairy products, as well as processed and raw meat.
EFFECT OF SOMATOTROPIN AND THYROXINE ON THE IN VITRO DEVELOPMENT OF BOVINE PREANTRAL FOLLICLES
Authors: Silva Talita Fernandes da , Costa Sanely Lourenço da , Costa Eduardo Paulino da , Guimarães José Domingos
Published: May 2018

Abstract The aim of the study was to evaluate the effect of recombinant bovine somatotropin (rbST) and thyroxine (T4) on survival and growth of bovine preantral ovarian follicles (PAOF) cultured in vitro. Ovarian fragments were collected in local abattoirs and immediately fixed for classical histology and transmission electron microscopy (non-cultured control). The other fragments were then cultured in situ for seven days in minimum essential medium alone (MEM+ - cultured control) or in the presence of 1,000 ng/mL rbST and 20 ng/mL T4, isolated or associated. After seven days, there was a reduction (P<0.05) in the percentage of normal follicles in MEM+ alone or with T4. In oocyte diameter, there was a reduction in MEM+ alone. There was no influence (P>0.01) of the medium used on the follicular diameter of the PAOF cultured for seven days. Ultrastructural analysis showed cell damage. In conclusion, the presence of rbST maintains the rate of morphologically normal follicles during the culture for seven days (observed by optical microscopy), but it does not exert beneficial effects on its ultrastructural integrity and oocyte and follicular growth.
The addition of jaboticaba skin flour to muffins alters the physicochemical composition and their sensory acceptability by children
Authors: Micheletti Jéssica , Soares Jaqueline Machado , Franco Bruna Callegari , Carvalho Izabella Renatta Almeida de , Candido Camila Jordão , Santos Elisvânia Freitas dos , Novello Daiana
Published: May 2018

Abstract This work aimed to evaluate the sensory acceptance by children of muffins containing different levels of jaboticaba skin flour. It also aimed to determine the physicochemical composition of the traditional product and compare it with that containing the highest level of jaboticaba skin flour showing acceptance similar to that of the traditional muffin. Five muffin formulations containing different levels of jaboticaba skin flour were prepared: 0% (standard), 4.5%, 9%, 13.5% and 18%. A group of 65 untrained tasters of both genders, aged from 7 to 10, took part in the sensory evaluation. The moisture, ash, protein, lipid, carbohydrate, calorie and dietary fibre levels were evaluated. The samples presented no significant alterations ( p > 0.05) for the attributes of appearance, aroma and colour. The formulations containing 0% and 4.5%, received the highest scores (p < 0.05) for flavour, texture and overall acceptance as compared to those with 13.5% and 18% jaboticaba skin flour. The sample with 9% was the one with the highest level of jaboticaba skin flour with acceptance similar to that of the traditional muffins. Higher moisture, ash and dietary fibre levels and lower lipid and protein levels were detected in the formulation with 9%, when compared to the traditional muffins, but there were no significant changes in the carbohydrate and calorie contents. It was concluded that a level of up to 9% jaboticaba skin flour in the muffins was well accepted by the child tasters, achieving a sensory acceptance similar to that of the traditional product and with good commercial potential.
Os papéis da sociedade civil como protagonista no processo de promoção do consumo sustentável: uma análise baseada na percepção de especialistas brasileiros
Authors: Oliveira Verônica Macário de , Gómez Carla Regina Pasa , Correia Suzanne Érica Nóbrega
Published: May 2018

Resumo Este artigo tem como objetivo analisar os papéis da sociedade civil para promover o consumo sustentável no contexto brasileiro. Considera-se que a promoção do consumo sustentável necessita da atuação da sociedade civil por meio de um processo emancipatório (SACHS, 2007), com o aprofundamento da democracia participativa e amplo exercício da cidadania (COSTA; TEODÓSIO, 2011; MICHELETTI; STOLLE, 2012). Isso porque consumo sustentável depende de mudanças estruturais associadas a fatores políticos, institucionais e de mercado, o que requer o desenvolvimento de propostas mais colaborativas, nas quais a sociedade civil exerça papéis de protagonista ao lado de governos e empresas. Assim, em termos de procedimentos metodológicos, foi realizada uma pesquisa com especialistas brasileiros na temática, usando o método Policy Delphi. Os resultados demonstram que dos papéis da sociedade civil analisados, apenas o carrotmob, no nível meso, não foi validado como relevante. Quanto aos demais papéis avaliados, apenas a prática do buycott foi classificado como “muito importante”, no nível micro, enquanto os outros foram classificados como “criticamente importante” no processo de promoção do consumo sustentável no contexto brasileiro.
Potencial disruptivo? A história de uma biotecnologia
Authors: Matos Lorena Bezerra de Souza , Ipiranga Ana Silvia Rocha
Published: May 2018

Resumo Nesta pesquisa, busca-se identificar e descrever historicamente o potencial disruptivo de uma biotecnologia vinculada a um laboratório de P&D da Rede Nordeste de Biotecnologia (Renorbio). Diferentes métodos foram utilizados, com base em uma perspectiva sociológica e com abordagem da análise de relatos e enredos históricos. Considerando as dimensões que fundamentam tecnologias disruptivas, argumenta-se que a biotecnologia justifica a sua potencialidade de disrupção ao articular construtos relacionados à dimensão do capacitador tecnológico. Observou-se que alguns fragmentos dos relatos transitam entre os construtos da dimensão inovação do modelo de gestão, sobretudo após a criação de uma spin-off. Contudo, os construtos que compõem essa dimensão são limitantes, assim como a ausência de relatos relacionados à dimensão sistema de valor comercial, obstando a realização de uma disrupção em todo o seu potencial. Entre as contribuições do artigo releva-se o uso da abordagem histórica no contexto da área da ciência & tecnologia.
Long term follow up of biomarkers of podocyte damage and renal function in patients with and without preeclampsia
Authors: Franco Ylbe Palacios de , Velazquez Karina , Segovia Natalia , Sandoval Gladys , Gauto Estefania , Palacios Ylbe V. Franco , Palacios Carlos R Franco
Published: May 2018

ABSTRACT Introduction: preeclampsia can be associated with future renal disease. Objectives: To measure changes in renal function overtime in patients with preeclampsia. Methods: urine and serum samples from eleven patients with preeclampsia and eight patients with a normal pregnancy were obtained during pregnancy, postpartum, and 3 years after delivery. Urine podocalyxin, protein, and serum creatinine were measured. Results: after 3 years, there were no significant differences in urinary podocalyxin in patients with or without preeclampsia: 4.34 ng/mg [2.69, 8.99] vs. 7.66 ng/mg [2.35, 13], p = 0.77. The same applied to urinary protein excretion: 81.5 mg/g [60.6, 105.5] vs. 43.2 mg/g [20.9, 139.3] p = 0.23. Serum creatinine was 0.86 mg/dL [0.7, 0.9] vs. 0.8 mg/dL [0.68, 1] p = 0.74 in those with and without preeclampsia. In normal patients, urinary podocalyxin decreased from 54.4 ng/mg [34.2, 76.9] during pregnancy to 7.66 ng/mg [2.35, 13] three years after pregnancy, p = 0.01. Proteinuria decreased from 123.5 mg/g [65.9, 194.8] to 43.2 mg/g [20.9, 139.3], p = 0.12. In preeclampsia patients, urinary podocalyxin decreased from 97.5 ng/mg [64.9, 318.4] during pregnancy to 37.1 ng/mg within one week post-partum [21.3, 100.4] p = 0.05 and 4.34 ng/mg [2.69, 8.99] three years after, p = 0.003. Proteinuria was 757.2 mg/g [268.4, 5031.7] during pregnancy vs. 757.2 mg/g [288.2, 2917] postpartum, p = 0.09 vs. 81.5 mg/g [60.6, 105.5] three years later, p = 0.01. Two patients still had proteinuria after 3 years. Conclusions: in preeclampsia patients, postpartum urinary podocalyxin decreased before proteinuria. After three years, serum creatinine, urinary podocalyxin, and protein tended to normalize, although some patients still had proteinuria.
Tempo de transição alimentar na técnica sonda-peito em recém-nascidos baixo peso do Método Canguru
Authors: Medeiros Andréa Monteiro Correia , Ramos Blenda Karen Batista , Bomfim Déborah Letticia Santana Santos , Alvelos Conceição Lima , Silva Talita Cardoso da , Barreto Ikaro Daniel de Carvalho , Santos Felipe Batista , Gurgel Ricardo Queiroz
Published: May 2018

RESUMO Objetivo Verificar o tempo despendido na transição da alimentação por gavagem para via oral exclusiva, na técnica sonda-peito, comparando RNs baixo peso, considerando suas intercorrências clínicas/médicas, submetidos ao peito exclusivo com aqueles que, além do peito, receberam complemento por copo/mamadeira. Método Estudo de coorte, analítico e longitudinal, com 165 RNs, divididos quanto à gravidade de intercorrências clínicas (G1 e G2) e quanto à via de dieta (A e B). Todos RNs eram baixo peso, do Método Canguru, estimulados no peito, conforme prescrição médica e rotina hospitalar. Pertenciam ao subgrupo A: RNs estimulados exclusivamente no peito, que mantiveram peito exclusivo no momento da alta, e ao subgrupo B: RNs que utilizaram copo/mamadeira em algum momento da internação hospitalar em complementação ao peito. Foi registrado o número de dias que o RN permaneceu em cada etapa da transição. Resultados O histórico de intercorrências médicas influenciou significativamente o tempo total de transição. Subgrupos G1-A (10 dias), G1-B (9 dias) e G2-A (12 dias), quando comparados ao grupo G2-B(16 dias), evidenciaram maior chance de alta antecipada. Conclusão RNs sem intercorrências clínicas importantes apresentaram chance de alta mais breve. RNs com intercorrências clínicas, que fizeram a transição da gavagem exclusivamente no peito, tiveram tempo de transição menor que aqueles que utilizaram complementação por copo/mamadeira. A transição alimentar pela técnica sonda-peito é importante para ser preconizada na atuação fonoaudiológica em Neonatologia.
Stability and adaptability of curled green-leaf lettuce lines using the REML/Blup mixed model
Authors: Candido Willame dos Santos , Soares Renato Silva , Franco Carolina Andrade , Diniz Guilherme Matos Martins , Silva Edgard Henrique Costa , Marin Marcus Vinicius , Braz Leila Trevisan
Published: May 2018

Abstract: The objective of this work was to estimate the stability and genotypic adaptability of advanced lines and cultivars of curled green-leaf lettuce (Lactuca sativa), in different growing environments and seasons, using the REML/Blup mixed model. Ten genotypes, seven cropping environments, and two growing seasons were studied in 2015. Plant yield traits were evaluated, and data were subjected to the Selegen-REML/Blup software. Genotype stability and adaptability were analyzed using the harmonic mean of genotypic values (HMGV) and the relative performance of genotypic values (RPGV), respectively. The harmonic mean of RPGV (HMRPGV) was used to simultaneously estimate the stability, adaptability, and yield of breeding lines or cultivars. Considering the combined analysis of the two seasons for the set of traits, the lines L6, L7, and L8 were selected as promising ones and recommended for planting. The breeding lines selected for all season exhibit good yield and are considered superior to the commercial cultivars Vanda and Vera.
Relationship between remote sensing data and field-observed interril erosion
Authors: Moraes André Geraldo de Lima , Carvalho Daniel Fonseca de , Antunes Mauro Antonio Homem , Ceddia Marcos Bacis
Published: May 2018

Abstract: The objective of this work was to evaluate the relationship between different remote sensing data, derived from satellite images, and interrill soil losses obtained in the field by using a portable rainfall simulator. The study was carried out in an area of a hydrographic basin, located in Médio Paraíba do Sul, in the state of Rio de Janeiro - one of the regions most affected by water erosion in Brazil. Evaluations were performed for different vegetation indices (NDVI, Savi, EVI, and EVI2) and fraction images (FI), derived from linear spectral mixture analysis (LSMA), obtained from RapidEye, Sentinel2A, and Landsat 8 OLI images. Vegetation indices are more adequate to predict soil loss than FI, highlighting EVI2, whose exponential model showed R2 of 0.74. The best prediction models are generated from the RapidEye image, which shows the highest spatial resolution among the sensors evaluated.
PÈRE-VERSION: A RELATIVIZAÇÃO DO NOME-DO-PAI
Authors: Castro Julio Cesar Lemes de
Published: May 2018

Resumo: O jogo de palavras père-version é utilizado por Lacan para aproximar os conceitos de sinthoma e perversão. Em seus desdobramentos teóricos, ele indica a dimensão real subjacente ao pai simbólico e serve para relativizar quatro diferentes aspectos do Nome-do-Pai: abstração, universalidade, normatividade e efetividade. Essa relativização, que se inicia por ocasião da primeira proposta de pluralização dos Nomes-do-Pai, torna-se passível de ser completada quando, no âmbito da topologia dos nós, o simbólico claramente perde a preeminência em relação aos outros registros.
ENTRE MORRER E EXISTIR: DA FALHA NA INSCRIÇÃO DO AUTOEROTISMO AOS IMPASSES DA PASSAGEM DE MENINA A MULHER NA ANOREXIA
Authors: Marochi Giovana Luiza , Cremasco Maria Virginia Filomena
Published: May 2018

Resumo: O presente artigo tem como objetivo compreender a manifestação da anorexia em mulheres. Partiremos da investigação da relação entre a falha na inscrição do autoerotismo e a manifestação da anorexia. Seguiremos para a averiguação de qual é a especificidade do funcionamento psíquico feminino que, para além dos componentes sociais associados às exigências estéticas, contribui para a manifestação dessa problemática no campo do feminino e quais são os impasses da passagem de menina a mulher que ela revela. Finalmente, visaremos compreender o que faz com que as anoréxicas cheguem a ponto de se darem a morrer.
ELEMENTOS INICIAIS PARA UMA CRÍTICA DA FORMAÇÃO PROFISSIONAL SUPERIOR INSPIRADA PELOS DISPOSITIVOS DA ESCOLA DE LACAN E A FORMAÇÃO DO ANALISTA
Authors: MEDEIROS ROBERTO HENRIQUE AMORIM DE
Published: May 2018

RESUMO: O artigo procura fomentar debate acerca da formação do psicanalista, por meio do resgate da história e dos elementos fundamentais da Escola Freudiana de Psicanálise, fundada por Lacan. Por fim, discute as possíveis contribuições lacanianas à formação do analista e propõe que os discursos circulantes na Escola e seus dispositivos também possam constituir analisadores para pesquisas sobre o problema da formação baseada em treinamento e reprodução técnica em profissões cujo objeto é o outro e o sofrimento humano.
Implicaciones bioéticas de la dispraxis odontológica y su relación con la formación educativa
Authors: Díaz-Torres Lidia Mallinaly
Published: May 2018

Propósito: el presente artículo es de revisión bibliográfica y enfatiza que la práctica odontológica como profesión de la salud en México cuenta con un marco ético y legal específico, que impulsa el desarrollo de los alumnos en un clima de respeto en el desempeño de una práctica profesional óptima, con la finalidad de que los estudiantes no incurran en dispraxis profesional una vez egresados de sus centros educativos. Periodo, origen y tipos de publicaciones: la revisión se hizo en el periodo comprendido entre enero del 2012 y septiembre del 2014, como base de investigación de la tesis de grado de maestría en Bioética en la esm del Instituto Politécnico Nacional, basada en información bibliográfica documental y artículos científicos. Punto de vista: es de suma importancia que en la formación del cirujano dentista deben estar presentes los conocimientos científicos, técnicos y humanísticos como la responsabilidad, el respeto, la beneficencia, la no maleficencia y la justicia, los cuales son necesarios para realizar una práctica adecuada. Finalmente, se plantea la necesidad de fortalecer una cultura bioética en los estudiantes, concientizando a los alumnos del sentido de la responsabilidad, el respeto y el valor a la vida, lo que permite el desarrollo de valores que aporten un cambio cultural de humanismo odontológico.