bluuebunny/crossref_metadata_2025 huggingface dataset:
INTEGRATED MODULAR MODEL LINKING METABOLISM, SIGNALING TRANSDUCTION AND GENE EXPRESSION REGULATION INHUMAN SKELETAL MUSCLE
Authors: Акбердин И.Р. , Киселев И.Н. , Пинтус С.С. , Вертышев А. , Махновский П.А. , Попов Д.В. , Колпаков Ф.А.
Published: January 2022

В докладе представлены результаты последовательного развития модульного представления и анализа математической модели метаболизма клеток скелетных мышц (Kiselev et al., 2019) с учетом сигнальных путей и процессов регуляции транскрипции генов, активируемых в ответ на физическую нагрузку, в компьютерной платформе BioUML (Kolpakov et al., 2019).
Complex Loop Dynamics Underpin Activity, Specificity and Evolvability in the (βα)8 Barrel Enzymes of Histidine and Tryptophan Biosynthesis
Authors: Romero-Rivera Adrian , Corbella Marina , Parracino Antonietta , Patrick Wayne M. , Kamerlin Shina Caroline Lynn
Published: January 2022

Enzymes are conformationally dynamic, and their dynamical properties play an important role in regulating their specificity and evolvability. In this context, substantial attention has been paid to the role of ligand-gated conformational changes in enzyme catalysis; however, such studies have focused on tremendously proficient enzymes such as triosephosphate isomerase and orotidine 5’-monophosphate decarboxylase, where the rapid (μs timescale) motion of a single loop dominates the transition between catalytically inactive and active conformations. In contrast, the (βα)8-barrels of tryptophan and histidine biosynthesis, such as the specialist isomerase enzymes HisA and TrpF, and the bifunctional isomerase PriA, are decorated by multiple long loops that undergo conformational transitions on the ms (or slower) timescale. Studying the interdependent motions of multiple slow loops, and their role in catalysis, poses a significant computational challenge. This work combines conventional and enhanced molecular dynamics simulations with empirical valence bond simulations to provide rich detail of the conformational behavior of the catalytic loops in HisA, PriA and TrpF, and the role of their plasticity in facilitating bifunctionality in PriA and evolved HisA variants. In addition, we demonstrate that, similar to other enzymes activated by ligand-gated conformational changes, loops 3 and 4 of HisA and PriA act as gripper loops, facilitating the isomerization of the large bulky substrate ProFAR, albeit now on much slower timescales. This hints at convergent evolution on these different (βα)8-barrel scaffolds. Finally, our work highlights the potential of engineering loop dynamics as a powerful tool to artificially manipulate the diverse catalytic repertoire of TIM-barrel proteins.
Mechanochemical synthesis of inverse vulcanized polymers
Authors: Yan Peiyao , Zhao Wei , McBride Fiona , Cai Diana , Dale Joseph , Hasell Tom
Published: January 2022

Inverse vulcanization, a sustainable platform, can transform an industrial by-product, sulfur, into polymers with broad green applications such as heavy metal capture and recyclable materials. However, the process usually requires high temperatures (≥159 °C), and the crosslinkers needed to stabilize the sulfur are therefore limited to high-boiling-point monomers only. Here, we report an alternative route for inverse vulcanization — mechanochemical synthesis (MS), with advantages of mild conditions (room temperature), short reaction time (3 h), high atom economy, less H2S, and broader monomer range. Successful generation of polymers using crosslinkers ranging from aromatic, aliphatic to volatile, including renewable monomers, demonstrates this method is powerful and versatile. Compared with thermal synthesis, the MS products show enhanced mercury capture. The resulting polymers show thermal and light-induced recycling. The speed, ease, versatility, safety, and green nature of this process offer a more sustainable future for inverse vulcanization and enables further unexpected discoveries.
Strontium Leaching Precedes SrIrO3 Dissolution During Electrochemical Water Oxidation
Authors: Akbashev Andrew R. , Roddatis Vladimir , Baeumer Christoph , Liu Tianchi , Mefford J. Tyler , Chueh William C.
Published: January 2022

Mechanistic studies of oxide electrocatalysts for heterogeneous water oxidation have been primarily focused on understanding the origins of activity. Despite encouraging progress, achieving long-term stability remains an important goal for their industrial implementation. In this work, we study the degradation pathways of a highly active SrIrO3 electrocatalyst during the oxygen evolution reaction (OER). SrIrO3 serves as a model system for perovskite AMO3 oxides as it can exhibit both A-cation leaching and transition metal (TM) oxide dissolution. Employing epitaxial SrIrO3 thin films, we explore the electrolyte- and potential-dependent leaching of Sr from the perovskite structure by following these processes through operando electrochemical atomic force microscopy (EC-AFM). Dissolution was imaged and quantified at the nanometer scale. We show that Sr leaching results in the in-situ formation of Sr1-xIrOy layer, with the leaching rate controlled via electrolyte composition. Crucially, Sr leaching occurs at a potential > 0.5V lower than that for transition metal oxide dissolution. Our study demonstrates that suppression of the A-site leaching is crucial for improving the overall stability of perovskite oxide during electrocatalysis.
Scalable Constant pH Molecular Dynamics in GROMACS
Authors: Aho Noora , Buslaev Pavel , Jansen Anton , Bauer Paul , Groenhof Gerrit , Hess Berk
Published: January 2022

Molecular dynamics (MD) computer simulations are used routinely to compute atomistic trajectories of complex systems. Systems are simulated in various ensembles, depending on the experimental conditions one aims to mimic. While constant energy, temperature, volume, and pressure are rather straightforward to model, pH, which is an equally important parameter in experiments, is more difficult to account for in simulations. Although a constant pH algorithm based on the $\lambda$-dynamics approach by Brooks and co-workers was implemented in a fork of the GROMACS molecular dynamics program, uptake has been rather limited, presumably due to the poor scaling of that code with respect to the number of titratable sites. To overcome this limitation, we implemented an alternative scheme for interpolating the Hamiltonians of the protonation states that makes the constant pH molecular dynamics simulations almost as fast as a normal MD simulation with GROMACS. In addition, we implemented a simpler scheme, called multisite representation, for modeling side chains with multiple titratable sites, such as imidazole rings. This scheme, which is based on constraining the sum of the $\lambda$-coordinates, not only reduces the complexity associated with parameterizing the intra-molecular interactions between the sites, but is also easily extendable to other molecules with multiple titratable sites. With the combination of a more efficient interpolation scheme and multisite representation of titratable groups, we anticipate a rapid uptake of constant pH molecular dynamics simulations within the GROMACS user community.
Towards a Mechanistic Model of Solid-Electrolyte Interphase Formation and Evolution in Lithium-ion Batteries
Authors: Spotte-Smith Evan Walter Clark , Kam Ronald L , Barter Daniel , Xie Xiaowei , Hou Tingzheng , Dwaraknath Shyam , Blau Samuel M , Persson Kristin Aslaug
Published: January 2022

The formation of passivation films by interfacial reactions, though critical for applications ranging from advanced alloys to electrochemical energy storage, is often poorly understood. In this work, we explore the formation of an exemplar passivation film, the solid electrolyte interphase (SEI), which is responsible for stabilizing lithium-ion batteries. Using stochastic simulations based on quantum chemical calculations and data-driven chemical reaction networks, we directly model competition between SEI products at a mechanistic level for the first time. Our results recover the Peled-like separation of the SEI into inorganic and organic domains resulting from rich reactive competition without fitting parameters to experimental inputs. By conducting accelerated simulations at elevated temperature, we track SEI evolution, confirming the postulated reduction of lithium ethylene monocarbonate to dilithium ethylene monocarbonate and H2. These findings furnish fundamental insights into the dynamics of SEI formation and illustrate a path forward towards a predictive understanding of electrochemical passivation.
A PROSPECTIVE STUDY FOR ASSESSMENT OF RISK FACTORS OF OPEN ANGLE GLAUCOMA
Authors: Rastogi Priye Suman
Published: January 2022

To assess cases of risk factors of open angle glaucoma. One hundred fourteen adult patients who were diagnosed with open angle Glaucoma of either gender was enrolled in the study. Parameters such as smoking history, family status of open angle glaucoma, presence of AMD, previous pseudo-exfoliation, previous cataract surgery and intraocular pressure (IOP) was recorded. Off the 114 patients, 70 were males and 44 were females. Age group 40-49 had 24, 50- 59 years had 36 and 60-70 years had 54. Smoking history was seen among 50, family history was seen among 64, AMD was present in 55, pseudo-exfoliation was present in 46 and previous cataract surgery was seen among 34. Statistical tests showed significant difference (P< 0.05). Various risk factors were smoking history, family history, AMD, pseudo-exfoliation and previous cataract surgery.
Centro de operações de emergência na COVID-19: a experiência do município do Rio de Janeiro
Authors: Oliveira e Cruz Débora Medeiros de , Carvalho Luciana Freire de , Costa Carolina Monteiro da , Aguilar Gislani Mateus Oliveira , Saraceni Valéria , Cruz Oswaldo Gonçalves , Durovni Betina , Soranz Daniel Ricardo , Oliveira Garcia Márcio Henrique de
Published: January 2022

O presente artigo descreve a experiência de implantação de um centro de operações de emergência (COE) para coordenação da resposta à pandemia de COVID-19 no município do Rio de Janeiro, Brasil. Seguindo o modelo de gestão de emergências em saúde pública preconizado pela Organização Mundial da Saúde (OMS), este centro de caráter temporário (COE COVID-19 RIO) foi ativado em janeiro de 2021. O relato foi estruturado com base em cinco eixos temáticos: arcabouço legal; estrutura, planos e procedimentos; articulações institucionais; informações em saúde para apoio decisório; e comunicação de risco. Entre os avanços importantes relacionados ao estabelecimento desta iniciativa, destacaram-se ganhos em governança para a organização do enfrentamento à COVID-19, aumento da sinergia entre setores e instituições, maior compartilhamento de informações em relação às medidas de prevenção e controle da doença, inovação nas análises epidemiológicas e ganhos na transparência e oportunidade na tomada de decisões. Concluiu-se que, mesmo sendo concebido em estágio avançado da pandemia na cidade, o COE COVID-19 RIO teve papel relevante na estruturação da resposta. Ainda, apesar do caráter temporário do COE, a experiência mostrou-se como importante legado para a condução de futuras emergências em saúde pública no município do Rio de Janeiro.
Islamic Banking Prospects, Challenges and Criticism: A Systematic Literature Review
Authors: Khan Azam Anwar , Ghias Saqib , Hyder Syed Irfan
Published: January 2022

Purpose: The article covers the prospects, challenges and criticism of Islamic Banking. There is still a confusion among people about the differences in Islamic and commercial banking. The implementation of Islamic banking is not as per the true spirit with which it was started.   

Methodology/Approach: A systematic literature review was conducted and a thorough research was carried out by studying 2725 articles and finally qualifying thirty articles (30 articles) for the review

Findings: The results revealed that there is still a confusion among people regarding the difference between Islamic and Conventional banking. The Islamic banks should organize more awareness programs to improve the knowledge of people regarding Islamic banks. The social objectives of Islamic banks are not highlighted from their operations.

Implications/Originality/Value: This articles contributes to the literature by giving important insights regarding the Islamic Banking industry. The Islamic Banks can definitely improve by adopting the suggestions given in paper.
Ensuring Viable Solutions in Resource-Constrained Language Teaching Settings: ESL Learners Perceptions about Computer-Assisted Language Testing (CALT)
Authors: Hussain Riaz , Zahid Muhammad Sumair , Alam Youshaib
Published: January 2022

Purpose: Across the globe, organizations operating in testing services have made optimum use of this technology and seem to have won greater trust and confidence of the test-takers. The purpose of the current study was to explore the perceptions of ESL learners about Computer-Assisted Language Testing (CALT). It further aimed to investigate the challenges and problems learners encounter during the test. Design/Methodology/Approach: The current study had two phases: CALT test and a questionnaire-based survey. In the first phase, the researchers designed and conducted a CALT test to give learners some exposure of CALT. With a quantitative approach, the researchers in the current study designed, piloted and administered a close-ended questionnaire to collect data about learners’ perceptions about CALT. Findings: The results revealed that the learners had positive perceptions about CALT. Some learners encountered challenges while practicing in CALT. Around 80% of the learners thought CALT was adequate in assessing the English language proficiency of the learners and that it was compatible with the existing circumstances. Implications/Originality/Value: In Pakistan, insufficient number of studies seemed to have been done by the researcher. The current study fills the existing gap.
Gauging the Sustainability of Corporatized State-Owned Enterprises (SOEs) in Pakistan
Authors: Irshad Saadia , Khakwani Maria Shams , Khalid Umar , Kouser Rehana
Published: January 2022

Purpose: In accordance with the Washington Consensus, most developing countries were forced to privatize state-owned enterprises (SOEs). Corporatization and partial privatization emerged as two alternative possibilities for any government in circumstances where full privatization was not practicable. Pakistan followed suit and began the partial privatization and corporatization of SOEs working in its economy. This research examines whether Pakistan's corporatization or partial privatization policies have improved the profitability of these state-owned enterprises.

Design/Methodology/Approach: If so, what variables contributed to this improvement in profitability, as measured by Return on Assets and Earnings per Share. The paper used data from 1990 to 2015 of thirteen SOEs, largely from the energy sector, that have been corporatized by partial privatization through stock market or other mechanisms.

Findings: Results exhibit that the primary criteria strongly related with increased performance of corporatized SOEs, according to our findings, are the appointment of non-government directors by companies and persistently positive Gross Domestic Product of the economy. On the other hand, debt commitments, ownership, and size of an SOE are all weak or insignificant variables in determining whether an SOE should be corporatized.

Implications/Originality/Value: Due to their strategic significance, the energy industry should continue to be governed and regulated by the government, but with a greater percentage of non-nominated members on their boards of directors to maintain corporate governance.
Further Development of Studies of Pressure Fields in the Arctic Region of Russia
Authors: Тучкова Наталия Павловна , Беляев Константин Павлович , Михайлов Гурий Михайлович , Сальников Алексей Николаевич
Published: January 2022

The results of studies of atmospheric pressure in the Arctic region of Russia in the period from 1948 to 2008 are presented. The analysis of the climatic seasonal variation of the atmospheric pressure fields is carried out. As the main research method, the probabilistic and statistical analysis of the time series of the pressure field 60 years long at fixed points in the region of the Arctic zone of Russia was used. In total, about 90,000 daily (in six-hour increments) pressure values were examined. On the basis of these data, a climatic seasonal variation was constructed as an averaging of the values of a given time series at each point in space and for a fixed date. The characteristics of the seasonal course, its amplitude and phase have been studied. These characteristics were analyzed and their geophysical interpretation was carried out. In particular, the minimum and maximum values ​​of the series were determined for the entire region and the time series of these characteristics were constructed. It is shown that the deviation is asymmetric, this is an unobvious research result. For the maximum and minimum, the best approximations were constructed, and these approximations were tested by known methods of statistical analysis, including maximum likelihood, least squares and goodness of fit methods (tests), in particular, the χ2-criterion. The conducted research has applications both purely physical (allows to explain the nature, genesis and distribution of large-scale atmospheric formations in a climatic year) and prognostic (allows understanding and tracking trends in climate, as well as quantitatively assessing the scale and variability of large-scale atmospheric processes). Numerical calculations were performed on the Lomonosov-2 supercomputer of the Lomonosov Moscow State University.
ISSUES OF DELIMITATION DISTINCTION AND APPLICATION OF NORMS PROVIDING FOR THE IMPLEMENTATION OF THE RIGHT TO BANK AND COMMERCIAL SECRETS
Authors:   Russian State University for the Humanities, Timofeev Stanislav V.
Published: January 2022

The article examines the institutions of banking and commercial secrets in the context of the application of the rules that govern the concepts. A distinction is made between the spheres of application of banking secrets and commercial secrets, gaps in legislation are identified and ways to eliminate them are proposed.
ECOSYSTEMS OF THE SHARING ECONOMY
Authors:   Moscow State Pedagogical University, Avdokushin Evgenii F. , Kuznetsova Elena G. ,   Moscow State Pedagogical University
Published: January 2022

The article analyzes the state and prospects of creating ecosystems in the sharing model – the economy of collaborative consumption (CCE) and sharing (SE). The authors show that the creation of ecosystems is most promising in the SE segment, although individual ecosystems can be formed and used in the CCE segment. Examples of foreign and Russian experience in creating such ecosystems are considered. The article provides a critical analysis of the points of view of foreign authors on the mixing of the principles of the functioning of the sharing economy and the cooperative, collaborative activities of companies. Sharing in many foreign publications is often commercialized while ignoring or obscuring its social essence. Sharing ecosystems are equated to the ecosystems of large corporations (financial, bigtechs), which, as the practice of their functioning testifies, lead to monopolization. At the same time, the sharing model, identified with simple cooperation, collaboration, “fits” into the model of a modern market economy. In Russia, ecosystems are created more often on the basis of large banks, and abroad on the basis of bigtechs. The marketplace model plays a significant role in the formation of ecosystems. In Russia, few of the companies operating according to the sharing model manage to create their own ecosystem, especially in the CCE segment.
Küme İçindeki İşletmelerin Kaynaklarının İşletme Performansına Etkisi ve Küme Kaynaklarından İlişkisel Sermayenin Aracı Etkisi
Authors: SAOTAY Hülya , DÖVEN Musa Said
Published: January 2022

Araştırmanın amacı, kümede faaliyet gösteren işletmelerin sahip olduğu işletme kaynaklarının işletme performansı üzerindeki etkisini ve işletme kaynaklarının performans üzerindeki etkisinde ilişkisel sermayenin aracı rolünü açıklamaktır. Araştırma, Eskişehir, Bilecik ve Kütahya’yı kapsayan EBK Seramik kümesinde yapılmıştır. Araştırmada tam sayım yöntemi kullanılmıştır. Bu kapsamda 115 seramik işletme yöneticisinden veriler toplanmıştır. Araştırma verilerinin analizinde IBM SPSS Statistics 22, SmartPLS 3.3.3 ve IBM SPSS eklenti program olan Process Macro v2 kullanılmıştır. Araştırma sonuçlarına göre işletme kaynaklarının alt boyutlarının işletme performansı üzerinde olumlu etkiye sahip olduğu görülmüştür. Ayrıca ilişkisel sermayenin güvene dayalı iş birliği boyutunun işletme kaynakları alt boyutları ve performans arasında aracılık rolüne sahip olduğu sonucuna ulaşılmıştır.
Ficción audiovisual serializada y democracia: Un estudio en la televisión pública en México
Authors: Pareja Sánchez Norma
Published: January 2022

Este trabajo aborda el papel que la ficción audiovisual serializada producida por la televisión pública en México tiene en la promoción de valores democráticos en el  marco de la crisis de la democracia representativa y las actuales transformaciones sociotecnológicas en el sistema mediático. El objetivo es diagnosticar su estado para determinar las oportunidades que posee para la democracia, concibiéndolas como una política cultural. Se sigue una metodología cualitativa con enfoque documental–analítico que revisa la producción de ficción audiovisual serializada en la televisión pública mexicana mediante la elaboración de una base de datos. Ésta da cuenta de que Canal Once ha producido 96% de las teleseries desde 1999, y es por tanto  precursora en el tema. No se han encontrado razones estructurales de ello, pero sí probablemente institucionales al traducir el mandato como televisora pública de informar, educar y entretener con la operacionalización del concepto entretenimiento de calidad. Se concluye que existe un potencial cívico-educativo con el edu-entretenimiento en la producción nacional de ficción audiovisual como herramienta de intervención en la televisión pública en México dado su escaso aprovechamiento por los distintos sistemas públicos de televisión, su persistencia y predominancia histórica en el entretenimiento mediático y el disfrute que supone.
Treré, E. (2020). Activismo mediático híbrido. Ecologías, imaginarios, algoritmos. FES Comunicación
Authors: Flores-Márquez Dorismilda
Published: January 2022

Reseña del texto de Emiliano Treté (2020). Activismo Mediático Híbrido. Ecologías, Imaginarios, Algoritmo. FES Comunicación.
Tipos de argumentación moral y temas prototípicos de discusión en Facebook: Un estudio cualitativo
Authors: Pérez Sánchez Rolando , Solís Umaña Mario , Jara Sanabria Fiorella , García Román Andrea
Published: January 2022

Este estudio persigue identificar temas centrales de debate en Facebook, desde la perspectiva de personas usuarias y concerniente a los criterios utilizados para la evaluación moral de dichos temas. Se establece una relación entre los mecanismos socio-cognitivos de la evaluación moral y cinco tipos filosóficos generales de juicio moral. El estudio de dicha correspondencia marca un campo de trabajo poco abordado por la investigación asociada. Se recurrió un diseño cualitativo fenomenológico, y se emplearon entrevistas grupales a un total de 32 estudiantes universitarios costarricenses (43% mujeres entre 18 y 24 años) para la recolección de información. Los resultados permitieron distinguir cuatro temas centrales a partir de los cuales se define el debate en esta red social. En estos intercambios operan esquemas cognitivos rígidos, cuyo contenido predominante corresponde a dos de los cinco tipos de juicio moral con los que se trabajó, es decir, el teologismo y el deontologismo. Se discuten los alcances, limitaciones e implicaciones del estudio para la comprensión de los intercambios comunicativos en las redes sociales y la formación de una ciudadanía digital.
Mediación de la diplomacia pública
Authors: Rodriguez Espinola Amanda
Published: January 2022

En la última década, los videojuegos como campo de estudio han ganado mayor relevancia, resultando en el reconocimiento de otros campos de estudio que los incluyen como extensión de su propia investigación, sumando nuevos retos y oportunidades a la forma en que se entienden esos campos. Si bien ha habido un aumento en la producción y estudio de videojuegos en disciplinas de estudios internacionales, como el desarrollo internacional y la salud global, se han realizado pocas investigaciones sobre sus posibilidades como herramientas de diplomacia pública. Empleando métodos cualitativos, este análisis teórico explora el uso de los videojuegos para la resolución de conflictos como parte de una estrategia de diplomacia pública. A partir de la teoría de contacto intergrupal imaginado se argumenta que los videojuegos fungen como catalizadores para la creación de un tercer espacio virtual en el que relaciones intergrupales pueden fomentar la disminución de prejuicios negativos y el incremento de empatía, elementos necesarios para programas de diplomacia pública.
Comunicación presidencial sobre la COVID-19 vía Twitter: México, España y Estados Unidos
Authors: Arévalo-Martínez Rebeca-Illiana , Del Prado Flores Rogelio , Góngora Cuevas Genny Elizabeth
Published: January 2022

En crisis como la COVID-19 se requiere una comunicación rápida y efectiva, por ello los presidentes al inicio de la pandemia usaron todos los medios posibles para informar e involucrar a la ciudadanía en el conocimiento y control de la crisis sanitaria. El objetivo de esta investigación mixta (análisis de contenido y estadística) fue comparar el impacto en la interacción y los comentarios de los usuarios relacionados con los temas de salud, economía y política, a partir de los tweets sobre la COVID-19 de los presidentes de México, España y Estados Unidos emitidos entre el 15 de marzo y el 15 de abril de 2020. Se analizaron todos los tweets de los presidentes (213) y una muestra por conveniencia del 1% de los comentarios (4,345). Entre los hallazgos de la interacción: más favoritos en México (66.1%) y España (55.7%), más retweets en Estados Unidos (72.5%), comentarios polarizados (positivos y negativos) en México y España hacia política, comentarios en Estados Unidos positivos hacia economía y negativos hacia política. En cuanto al lenguaje de los presidentes, en España y México estuvo más relacionado con satisfacer necesidades de la población; mientras que, en Estados Unidos con suministros médicos, ventiladores y ayudar a otros...
Hydrogeological Features of Lithological Units, Groundwater Level and Flow Rate Map of Acıgöl Basin (Denizli)
Authors: KARAMAN Muhittin , Taşdelen Suat , Budakoğlu Murat
Published: January 2022

Son yıllarda, küresel ölçekte yaşanan yeraltısuyu problemleri nedeniyle, sürdürülebilir yeraltısu kaynaklarının hidrojeolojik özelliklerinin ortaya çıkarılması oldukça önem kazanmıştır. Bu çalışmada, Acıgöl Havzasının litolojik birimlerinin
hidrojeolojik özellikleri belirlenerek havzadaki akifer türlerinin karakterizasyonu ve sınıflaması, yeraltısuyu barındıran litolojik birimler, yüksek debili yeraltısuyu barındıran akiferler ve bunların bulundukları konumsal alanlar
CBS (Coğrafi Bilgi Sistemleri) ortamında haritalanmıştır. Aynı zamanda, yeraltısuyu seviye haritası üretilerek yeraltısuyu-göl beslenme ilişkisi ortaya konmuştur. Havzadaki allokton, paraotokton ve neootokton litolojik birimler,
hidrojeolojik özellikleri ve akifer olabilme potansiyelleri bakımından geçirimli (erime çatlaklı kaya ortam akiferi, taneli ortam akiferi), yarı geçirimli (akitard) ve geçirimsiz (akifüj) ortam olarak ayrımlanmıştır. Oligosen Acıgöl
Grubu ve Bodrum Napı birimleri havzadaki gölü besleyen temel akiferlerdir. Marmaris Peridotiti, İğdir Metamorfitleri, Kızılcadağ Melanj ve Olistostromu, Pliyo-Kuvaterner Marn Silt- Kil-Çamurtaşı ve Çameli Formasyonundaki Çamurtaşı-Marn
Üyesi hidrolik iletkenliği olmayan geçirimsiz ortamlardır. Akım yönünün göle doğru olduğu yeraltısuları gölü besler. Acıgöl Fayı ve Maymundağı-Dazkırı Fayı, yüksek debili yeraltısularının bulunduğu ortamlardır.
Sustainability Strategy for Small-Scale Fisheries Management: Case Study in Semarang City Coastal, Indonesia
Authors: Malik Jamaludin , Kristiana Hendi
Published: January 2022

Small-scale fisheries in Semarang City have complex problems. In the existing condition, overcapacity and over-exploited have occurred. At the level of sustainability, each aspect of management (environment, fish resources, facilities and technology, socioeconomic, institutional and governance) is a challenge to achieve sustainable fisheries management in Semarang City. This study aims to formulate a sustainability strategy for small-scale fisheries management in Semarang City. The sustainability strategies for small-scale fisheries management in Semarang City that can be formulated are: (1) increasing efforts to conserve fish resources and ecosystems; (2) increasing the income and welfare of fishermen and poverty alleviation; (3) increase the productivity of capture fisheries; (4) improve law enforcement/fisheries regulations.
EVALUATION OF METABOLIC SYNDROME AND OBESITY IN WOMEN WITH BREAST CANCER TREATED IN A SERVICE WITH INTERDISCIPLINARY ATTENTION. A PROSPECTIVE COHORT
Authors: Prado Vanildo , Buttros Daniel Araújo Brito , Pessoa Eduardo Carvalho , Vespoli Heloísa Maria Lucca , Nahás Eliana Aguiar Petri
Published: January 2022

Introduction: Patients with breast cancer have a higher risk of gaining weight and of presenting with metabolic syndrome (MS), with worsening overall and specific survival. Intervention from an interdisciplinary team can influence the prognosis. Objective: To evaluate the occurrence of metabolic syndrome and its components in women during the first year after diagnosis of breast cancer. Methods: Prospective, single-centered clinical study that included women with a recent diagnosis of breast cancer, age ≥40 years, histological diagnosis of breast cancer, without metastatic disease and without established cardiovascular disease (CVD). Clinical and anthropometric data (blood pressure, body mass index [BMI] and waist circumference) were collected through interviews and physical examination. For biochemical analysis, HDL, triglycerides (TG) and glucose were requested. Women with MS were considered to have three or more diagnostic criteria: waist circumference (WC)>88 cm; TG³150 mg/dL; HDL88 cm) in the studied period, with mean BMI of 28.9 kg/m2 , 28.8kg/m2 and 28.8 kg/m2 and WC equal 97.2 cm, 97.2 cm and 96.7 cm, at T0, T6 and T12 moments, respectively (p>0.05). When comparing the individual MS criteria between the three assessment moments, there was only a statistical difference in the triglyceride and glycemia criteria. The analysis of glycemia showed a decrease in mean values, from 106.6 mg/dL in T0m, 100.4 mg/dL in T6m and 98.9 mg/dL in T12m (p=0.004). Regarding TG, an increase in mean values was observed, from 121 mg/dL in T0m, 139.4 mg/dL in T6m and 148.4 mg/dL in T12m (p=0.003). Conclusion: Women with breast cancer submitted to interdisciplinary evaluation did not show an increase in the occurrence of MS during the first year after cancer diagnosis. Among the components of MS, there was a reduction in blood glucose values and an increase in triglyceride values.
CROSS-SECTIONAL ANALYSIS OF CLINICAL AND MORPHOLOGICAL FACTORS OF BREAST CANCER IMMUNOPHENOTYPES: A COMPARATIVE STUDY OF TWO DIFFERENT METHODOLOGIES OVER A 24‑YEAR HISTORICAL SERIES
Authors: Vieira Daniella Serafin Couto , Walter Laura Otto , Moraes Ana Carolina Rabello de , Silva Jr João Péricles da , Silva Maria Cláudia Santos-
Published: January 2022

Introduction: Breast cancer (BC) is the most incident form of cancer in women worldwide. The widespread use of breast screening programs, as well advances in molecular biology, and new drugs in chemotherapy have contributed to the recent survival rate improvement in high income countries. Furthermore, the study of cancer genome led to the elucidation of the intrinsic subtypes of invasive breast cancer (IBC), consequently, the success rate of targeted therapies improved the outcome in patients. However, considering that immunohistochemistry (IHC) is one of the main methods to determine the profile of protein expression in surgical pathology, most antibodies used have a presumed or already established role and represent proteins whose transcription has been previously described in genetic profile studies. Objectives: Describe the prevalence of IBC in women admitted to a public hospital in Brazil from 1994 to 2018, to establish a correlation between two models of immunohistochemical analysis, the 13th St. Gallen Conference classification and the biomarkerdefined subtypes based on HER2 and estrogen receptor (ER) status, and to investigate the profile of these cases. Methods: Retrospective database analysis was performed. 1,335 women with histologic diagnosis of IBC were included in the study from a public hospital in Brazil between 1994 and 2018. Frequencies and univariate associations were estimated by using chi-square tests. Agreement between the immunohistochemical groups were tested by using Cohen’s kappa coefficients. Results: The mean age was 56.1 years. The most prevalent subtype was luminal B/HER2 and the frequency of tumors with worse prognosis was 62.7%. An association was found between histological grade 3 (G3) and the worst prognostic subtypes: non-luminal A (OR=31.18; 95%CI 13.76–70.64), TNBC (OR=8.77; 95%CI 6.20–12.41), non-ER+/HER2- (OR=5.37; 95%CI 4.11–7.04) and ER-/HER2- (OR=8.50; 95%CI 6.10–11.85). A similar association was found for nuclear G3: non-luminal A (OR=6.3; 95%CI 4.29–9.47), TNBC (OR=5.14; 95%CI 3.64–7.31), non-ER+/HER2- (OR=4.83; 95%CI 3.80–6.15) and ER-/HER2- (OR=5.41; 95%CI 3.92–7.50). When the two models of immunohistochemical analysis were compared, the results showed an agreement rate of 99.48% to 100%. Conclusions: Our results show that most cases had worse outcomes, and there was absolute agreement between the two models of immunohistochemical analysis. These results can contribute to institutions that do not have molecular investigation, enabling accessible tools in routine practice.
PAPEL DA ANÁLISE BIBLIOMÉTRICA NA PRODUÇÃO DO REFERENCIAL TEÓRICO DE UM ESTUDO DE CASO: EXPERIÊNCIA NO RELATO DE PACIENTE COM DIAGNÓSTICO DE SCHWANNOMA TRIGEMINAL
Authors: Gama Renato Faria da , Siqueira Eliza Barroso , Santos Ellen de Brito Oliveira dos , Torquato Fernanda Pinto
Published: January 2022

Introdução

Eventos clínicos raros ou com características peculiares frequentemente são apresentados na literatura por meio de relato de caso. Neste tipo de documento se descreve a história clínica, o
Knowledge, attitude and practice towards facemask use amid the COVID-19 pandemic among public transport drivers in Debre-Tabor town, Ethiopia
Authors: Gashaw Mehiret Wubet , Libsuye Yalgaw Zimamu
Published: January 2022

Background: For the prevention of respiratory infection similar to the current pandemic COVID-19, face masks are considered an effective method. Coronavirus disease (COVID-19) is a highly transmittable virus that continues to disrupt livelihoods, particularly those of low-income segments of society, around the world has poor knowledge towards facemask at the same time has huge gape towards attitude which affects the behaviors. Therefore this study was aimed to assess knowledge, attitude, and practice towards facemask use amid the COVID-19 pandemic among public transport drivers in Debre-Tabor town, Ethiopia, 2021. Methods: A cross-sectional study was conducted among 407 public transport drivers in Debre-Tabor town from July to August 2021. The study participants were selected using a simple random sampling technique after proportionally allocating the sample size from the total number of public transport drivers, and finally, study subjects were elected continuously working in Debre- Tabor Town public transport drivers. The data were collected by trained data collectors using a structured questionnaire with face-to-face interview administered questioners and an on-the-spot observational checklist. The collected data were checked, coded, and entered into SPSS version 23, and for data cleaning and analysis. Result: A total of 407 drivers responded to the questionnaire with a response rate of 96.4% were participated in this study. The mean age was 32.75 years (range: 19-45 years). Among them majority was male 383(94.1%) and the majority of 177(43.5%) were Bajaj drives. Among the responders, 114(28%) used radio to gather information, and 41(10.1%) drivers where were caught by COVID-19, but, only 30(7.4%) were vaccinated COVID-19 vaccine. Knowledge, attitude and practices regarding facemask use among these drivers were 368(90.4% [95% CI: 87.7-93.1]). 163(40% [95% CI: 37.5% - 43.2%]), and 23 ((5.6%) [95% CI: 3.7% - 8.3%]) Regarding facemask use against COVID-19 infection respectively. Conclusion and recommendation: The current study was able to demonstrate 90.4% of drivers had good knowledge. Positive attitude and practice levels of face mask use among drivers were less than half of them or 40%, and 5.6% respectively. There is a high supply of Surgical Face masks but poor attitude and practice. Almost all of the participants don’t wear a face mask despite having good knowledge about the transmission routes of COVID-19. The government COVID-19 prevention task force or health sector should be continued their awareness creation to bring behavioral change for the implementation of the COVID-19 prevention method, especially facemask.
Analisis Didaktis untuk Meningkatkan Hasil Belajar Calon Guru Fisika Ditinjau dari Gaya Kognitif dan Gaya Belajar
Authors:   Prodi Pendidikan Fisika, FKIP, Universitas Mataram, Busyairi Ahmad , Harjono Ahmad ,   Prodi Pendidikan Fisika, FKIP, Universitas Mataram, Zuhdi Muhammad ,   Prodi Pendidikan Fisika, FKIP, Universitas Mataram
Published: January 2022

This study aims to analyze the learning outcomes of prospective physics teachers in terms of cognitive and learning styles. The sample consisted of 47 prospective physics teachers at the University of Mataram. The instruments used consisted of the Group Embedded Figures Test (GEFT), the VAK learning style questionnaire, and the learning outcomes test instrument. The research data were then categorized and analyzed using descriptive statistics to see a picture of student learning outcomes in terms of their learning styles and cognitive styles. Based on the results of data analysis, it can be seen that there are differences in learning outcomes between students who have a field independence (FI) cognitive style and students who have a field dependence (FD) cognitive style. Students who have FI cognitive style tend to get better scores when compared to FD. When viewed from the learning style, it can be seen that the number of students who have visual learning styles is 46.80%, audio is 8.51%, and kinesthetic is 44.68%. Students who have a kinesthetic learning style tend to get better scores when compared to students who have a visual and audio learning style. By paying attention to the characteristics and percentage of students who have FI and FD cognitive styles and students who have visual, audio, and kinesthetic learning styles, one alternative learning that can be used to improve student learning outcomes is cooperative or experimental-based collaborative learning model.
Analisis Deskriptif Kekuatan Otot Peras Tangan
Authors:   Universitas PGRI Adi Buana Surabaya, Tino Reyhan , hayati Hayati ,   Universitas PGRI Adi Buana Surabaya, Pieter Pelamonia Shandy ,   Universitas PGRI Adi Buana Surabaya
Published: January 2022

The maximum strength of the hand-squeeze muscles will give the grip strength when making the punch. With good hand-wringing muscle strength, it can increase the power of the punch which affects accuracy. The purpose of this study was to determine the effect of hand-squeezing muscles on blows in badminton. With a large hand-squeeze muscle strength, it can increase the strength of the hand swing which can affect the outcome of the hit. This study uses a quantitative research approach with descriptive analysis research type. This research approach is to collect data in the form of numbers. The method used is descriptive analysis. The research subjects were members of the student activity unit (ukm) badminton at the PGRI Adi Buana University Surabaya, which amounted to 20 members. The data collection method in this study was to measure the strength of the hand-squeeze muscles using a dynamometer handgrip measuring instrument. Based on the results of descriptive analysis using SPSS 20, it shows that the average hand-squeeze muscle strength of male members is 44.85, which is included in the "medium" category. Then for the hand-squeezing muscle strength of the average woman is 27.20 which is included in the "medium" category. From these results, it can be seen that the strength of the hand-squeezing muscles in the badminton student activity unit (ukm) of the Universitas PGRI Adi Buana Surabaya is in the "medium" category.
THE IMPORTANCE OF MEASURING THE GAP LEVEL OF INFORMATION SYSTEM USER SATISFACTION IN THE WORLD OF EDUCATION IN UNIVERSITY: ELECTRONIC SERVICE QUALITY MODEL
Authors: Efendi Mochammad Arif , Mahjudin Mahjudin , Soelistya Djoko
Published: January 2022

Education is an important thing in life in order to develop human potential and increase the quality of Human Resources and Human Resources are needed by educational institutions in order to gain success and achieve goals. Servqual in services in the academic field by using the e-servqual method (electronic - service quality). The University is one of the higher education institutions that participate in educating the nation's life and the quality of service has a significant effect on user satisfaction and there is still an academic information system used by the University that is still not optimal.

This research is a quantitative study with a descriptive statistical approach with 200 students as respondents. The measurement method uses the E-Servqual model. The results of the study based on calculations in measuring the gap show user satisfaction using the electronic service quality method that the Academic Information System has not provided services that have not been maximized in the form of fulfillment and efficiency because the perception is still below expectations while measuring the level of user satisfaction gap as a whole by using the CSI (Customer Satisfaction Index) value is 79% and shows that the quality of the University's academic information system services is good.
THE EFFECT OF CONSUMER CONFIDENCE ON WORD OF MOUTH IN MAYBELLINE PRODUCTS
Authors: Choiriyah Faizzatul , Rejeki Asri , Endah Noer Suci
Published: January 2022

This study aims to determine the effect of consumer trust on word of mouth on Maybelline products. This study uses a quantitative approach using incidental sampling technique and gets 59 samples of students from the Accounting Study Program and Management Study Program. The method of collecting data on the Consumer Trust and Word of Mouth variables used a questionnaire compiled and modified by the researcher on a Likert scale. Test the validity of the scale using content validity. Scale reliability test using Alpha Cronbach technique. The results of data analysis using the Simple Linear Regression technique with the statistical program IBM SPSS Statistics 25, it is known that the value of R Square or the coefficient of determination is 0.403 from the consumer confidence variable, which means that the influence of consumer confidence on word of mouth is 16,3%, while the rest is influenced by other variables. The results of the regression coefficient test show that in the Sig column the independent variables and constants have a significance level below 0.05 and this shows that there is an influence of consumer trust on word of mouth.
Influence of Reaction Time and Hydrochloric Acid Volume on Rutile Titanum Dioxide Nanorods Thin Film
Authors: Norazlina Ahmad , Azman Talib , Fariza Mohamad , Khairul Ahmad Mohd , Wibowo Kusnanto Mukti
Published: January 2022

Titanium dioxide (TiO2) nanostructured materials have attracted attention due to their application at various fields such as photocatalysis, solar cell and photochemical applications. Whereas TiO2 could exhibit high efficiency of solar cell and economical than traditional silicon solar cells. In this study, hydrothermal method demonstrated to synthesis TiO2 nanorods properties at different hydrothermal reaction times and various hydrochloric acid volumes. Increasing the reaction time could influence the thickness towards high crystalline rutile formation while modifying the hydrochloric (HCl) acid concentration favours a great influence on the morphologies and alignment of the nanostructure. The result is beneficial for improvements thin film power conversion efficiency.
Midwifery Care for Mrs. K's Baby with Abdominal Bloating Using Telon Oil
Authors: Lestari Nofita Tri , Y Diah Atmarina , Dewi Sawitri
Published: January 2022

Bloating (meteorism, tympanities) is a symptom that indicates the presence of air or gas in the abdominal or intestinal cavity (Gina et al., 2020). In newborns (neonates) occurs because the digestive system in neonates is immature, besides that there are not enough digestive enzymes available at birth, and will only reach sufficient levels with increasing age, this is as stated by Padila et al. , 2019. To overcome flatulence in infants, non-pharmacological therapy can be used, namely by using telon oil by massaging it on the baby's stomach, this can reduce bloating in infants. To determine the application of telon oil to reduce bloating in new born. Case study report using descriptive method, the location of the residence of Mrs. K in Nangkod Village Rt02/05, Kejobong District, Purbalingga Regency. The subject of the case study was a 15-day-old newborn with flatulence. Time of case study on 9 April 2021. Data collection techniques include interviews and secondary studies including documentation and literature studies. The general condition of the new born is good, after massaging using telon oil the baby fart. Giving massage using telon oil is effective for reducing flatulence in babies.
The Effect of Health Education with PHBS Media on the Knowledge Level of Santri Pondok Zam-Zam Islamic Boarding School, Cilongok
Authors: Maulidian Krisna , Linggardini Kris
Published: January 2022

Clean and healthy living behavior (PHBS) is one way to maintain health to avoid various diseases caused by bacteria and viruses. The boarding school environment that applies dormitory education makes the spread of diseases often occur such as scabies (skin disease), scabies, diarrhea, ARI. Knowledge of PHBS coupled with behavior is very important to avoid the disease. The dissemination of knowledge using video is  more attractive to students so that the enthusiasm to learn about the importance of PHBS will be conveyed.To determine the effect of health education with the video media on Clean and Healthy Behavior (PHBS) on the knowledge level of students at the Zam-Zam Islamic Boarding School Cilongok.This study uses quantitative research, with a pre-experimental design and a one- group pretest-posttest approach without control design. The sample used in this study were 60 respondents, the sampling technique was cluster sampling.The results showed that the knowledge score before intervention with an average of 18.76 with a standard deviation of 2.94 increased to 25.96 with a standard deviation of 0.86. The results of bivariate analysis using the Wilcoxon test, obtained a Z value of -6749 and a significance value of 0.0001 (p <0.05). There is an effect of health education with the media of Clean and Healthy Behavior (PHBS) video on the knowledge level of students at the Zam-Zam Islamic Boarding School Cilongok