bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Figure 2 from Growth Inhibition of Ovarian Tumor–Initiating Cells by Niclosamide
Authors: Yo Yi-Te , Lin Ya-Wen , Wang Yu-Chi , Balch Curt , Huang Rui-Lan , Chan Michael W.Y. , Sytwu Huey-Kang , Chen Chi-Kuan , Chang Cheng-Chang , Nephew Kenneth P. , Huang Tim , Yu Mu-Hsien , Lai Hung-Cheng
Published: April 2023

PDF file, 2736KB, Niclosamide treatment (10mg/kg/daily) was given intraperitoneally every week one day after OTICs inoculation in NOD/SCID mice. Furthermore, Body weights remained constant during niclosamide treatment demonstrating a lack of systemic toxicity.
SupplementaryTable 1 from The Effect of Different Linkers on Target Cell Catabolism and Pharmacokinetics/Pharmacodynamics of Trastuzumab Maytansinoid Conjugates
Authors: Erickson Hans K. , Lewis Phillips Gail D. , Leipold Douglas D. , Provenzano Carmela A. , Mai Elaine , Johnson Holly A. , Gunter Bert , Audette Charlene A. , Gupta Manish , Pinkas Jan , Tibbitts Jay
Published: April 2023

PDF file - 101K, Mean (� SE) total antibody and conjugate pharmacokinetic parameter estimates following IV administration of T-DM1 or T-SPP-DM1 in female beige nude XID mice.
Supplementary Figure 1 from Genetic Variation That Predicts Platinum Sensitivity Reveals the Role of miR-193b* in Chemotherapeutic Susceptibility
Authors: Ziliak Dana , Gamazon Eric R. , LaCroix Bonnie , Kyung Im Hae , Wen Yujia , Huang Rong Stephanie
Published: April 2023

PDF file, 65K, The Pearson correlation coefficient distribution of gene pairs.
Supplementary Figure Legend 1 from The Effect of Different Linkers on Target Cell Catabolism and Pharmacokinetics/Pharmacodynamics of Trastuzumab Maytansinoid Conjugates
Authors: Erickson Hans K. , Lewis Phillips Gail D. , Leipold Douglas D. , Provenzano Carmela A. , Mai Elaine , Johnson Holly A. , Gunter Bert , Audette Charlene A. , Gupta Manish , Pinkas Jan , Tibbitts Jay
Published: April 2023

PDF file - 76K
Supplementary Figure Legends 1-5 from High TUBB3 Expression, an Independent Prognostic Marker in Patients with Early Non–Small Cell Lung Cancer Treated by Preoperative Chemotherapy, Is Regulated by K-Ras Signaling Pathway
Authors: Levallet Guénaëlle , Bergot Emmanuel , Antoine Martine , Creveuil Christian , Santos Adriana O. , Beau-Faller Michelle , de Fraipont Florence , Brambilla Elisabeth , Levallet Jérôme , Morin Franck , Westeel Virginie , Wislez Marie , Quoix Elisabeth , Debieuvre Didier , Dubois Fatéméh , Rouquette Isabelle , Pujol Jean-Louis , Moro-Sibilot Denis , Camonis Jacques , Zalcman Gérard
Published: April 2023

PDF file - 64K
Supplementary Table 3 from Activity of a Py–Im Polyamide Targeted to the Estrogen Response Element
Authors: Nickols Nicholas G. , Szablowski Jerzy O. , Hargrove Amanda E. , Li Benjamin C. , Raskatov Jevgenij A. , Dervan Peter B.
Published: April 2023

PDF File - 241K, Genes affected at least 2-fold by polyamide (1 �M) and unaffected by E2 addition were analyzed using BP_FAT GO term on the DAVID functional annotation tool.
Supplementary Table 1 from Activity of a Py–Im Polyamide Targeted to the Estrogen Response Element
Authors: Nickols Nicholas G. , Szablowski Jerzy O. , Hargrove Amanda E. , Li Benjamin C. , Raskatov Jevgenij A. , Dervan Peter B.
Published: April 2023

PDF File - 45K, Table of genes up- or down- regulated by 2- and 4- fold by E2 or 1 (1.0 �M), with FPKM > 20.
Supplementary Figure and Table Legends from Activity of a Py–Im Polyamide Targeted to the Estrogen Response Element
Authors: Nickols Nicholas G. , Szablowski Jerzy O. , Hargrove Amanda E. , Li Benjamin C. , Raskatov Jevgenij A. , Dervan Peter B.
Published: April 2023

PDF File - 98K, Supplementary Figure and Table Captions.
Supplementary Figure 8 from Activity of a Py–Im Polyamide Targeted to the Estrogen Response Element
Authors: Nickols Nicholas G. , Szablowski Jerzy O. , Hargrove Amanda E. , Li Benjamin C. , Raskatov Jevgenij A. , Dervan Peter B.
Published: April 2023

PDF File - 219K, Fluorescence microscopy of mechanically disintegrated tumors harvested from mice dosed with 5. Nuclear fluorescence similar to what is seen in vitro and in fixed frozen sections in vivo is observed.
Supplementary Figure 3 from Activity of a Py–Im Polyamide Targeted to the Estrogen Response Element
Authors: Nickols Nicholas G. , Szablowski Jerzy O. , Hargrove Amanda E. , Li Benjamin C. , Raskatov Jevgenij A. , Dervan Peter B.
Published: April 2023

PDF File - 16K, qRT-PCR analysis of Tff1 mRNA reduction after treatment with 1 for 96h is dose responsive.
Supplementary Figure 6 from Breakdown of the FLT3-ITD/STAT5 Axis and Synergistic Apoptosis Induction by the Histone Deacetylase Inhibitor Panobinostat and FLT3-Specific Inhibitors
Authors: Pietschmann Kristin , Bolck Hella Anna , Buchwald Marc , Spielberg Steffi , Polzer Harald , Spiekermann Karsten , Bug Gesine , Heinzel Thorsten , Böhmer Frank-Dietmar , Krämer Oliver H.
Published: April 2023

PDF file, 46K, IL-3-independent Ba/F3 cells expressing FLT3-ITD are more strongly affected by LBH589/AC220 combinations than IL-3-dependent control cells.
Supplementary Figure 4 from Breakdown of the FLT3-ITD/STAT5 Axis and Synergistic Apoptosis Induction by the Histone Deacetylase Inhibitor Panobinostat and FLT3-Specific Inhibitors
Authors: Pietschmann Kristin , Bolck Hella Anna , Buchwald Marc , Spielberg Steffi , Polzer Harald , Spiekermann Karsten , Bug Gesine , Heinzel Thorsten , Böhmer Frank-Dietmar , Krämer Oliver H.
Published: April 2023

PDF file, 48K, LBH589 and AC220 synergistically induce Apoptosis in MV4-11 cells.
Supplementary Table 3 from Identification of Docetaxel Resistance Genes in Castration-Resistant Prostate Cancer
Authors: Marín-Aguilera Mercedes , Codony-Servat Jordi , Kalko Susana G. , Fernández Pedro L. , Bermudo Raquel , Buxo Elvira , Ribal María José , Gascón Pedro , Mellado Begoña
Published: April 2023

PDF file - 45K
Supplementary Figure 3 from Breakdown of the FLT3-ITD/STAT5 Axis and Synergistic Apoptosis Induction by the Histone Deacetylase Inhibitor Panobinostat and FLT3-Specific Inhibitors
Authors: Pietschmann Kristin , Bolck Hella Anna , Buchwald Marc , Spielberg Steffi , Polzer Harald , Spiekermann Karsten , Bug Gesine , Heinzel Thorsten , Böhmer Frank-Dietmar , Krämer Oliver H.
Published: April 2023

PDF file, 38K, Caspase 3 contributes to the degradation of FLT3.
Supplementary Table 2 from Identification of Docetaxel Resistance Genes in Castration-Resistant Prostate Cancer
Authors: Marín-Aguilera Mercedes , Codony-Servat Jordi , Kalko Susana G. , Fernández Pedro L. , Bermudo Raquel , Buxo Elvira , Ribal María José , Gascón Pedro , Mellado Begoña
Published: April 2023

PDF file - 32K
Supplementary Figure 2 from Breakdown of the FLT3-ITD/STAT5 Axis and Synergistic Apoptosis Induction by the Histone Deacetylase Inhibitor Panobinostat and FLT3-Specific Inhibitors
Authors: Pietschmann Kristin , Bolck Hella Anna , Buchwald Marc , Spielberg Steffi , Polzer Harald , Spiekermann Karsten , Bug Gesine , Heinzel Thorsten , Böhmer Frank-Dietmar , Krämer Oliver H.
Published: April 2023

PDF file, 43K, FLT3-ITD knockdown sensitizes AML cells for HDACi-induced apoptosis.
Supplementary Figure 1 from Breakdown of the FLT3-ITD/STAT5 Axis and Synergistic Apoptosis Induction by the Histone Deacetylase Inhibitor Panobinostat and FLT3-Specific Inhibitors
Authors: Pietschmann Kristin , Bolck Hella Anna , Buchwald Marc , Spielberg Steffi , Polzer Harald , Spiekermann Karsten , Bug Gesine , Heinzel Thorsten , Böhmer Frank-Dietmar , Krämer Oliver H.
Published: April 2023

PDF file, 31K, LBH589 induces histone acetylation in MV4-11 cells.
Supplementary Tables 1-2 from VS-5584, a Novel and Highly Selective PI3K/mTOR Kinase Inhibitor for the Treatment of Cancer
Authors: Hart Stefan , Novotny-Diermayr Veronica , Goh Kee Chuan , Williams Meredith , Tan Yong Cheng , Ong Lai Chun , Cheong Albert , Ng Bee Kheng , Amalini Chithra , Madan Babita , Nagaraj Harish , Jayaraman Ramesh , Pasha Khalid M. , Ethirajulu Kantharaj , Chng Wee Joo , Mustafa Nurulhuda , Goh Boon Cher , Benes Cyril , McDermott Ultan , Garnett Mathew , Dymock Brian , Wood Jeanette M.
Published: April 2023

XLS file - 167K, Table 1: Cell line drug sensitivity data for SB2343 and mutations in cancer genes. Table 2: Results from MANOVA analysis of cancer genes as modifiers of drug sensitivity
Supplementary Methods, Figure Legends 1-7, Table Legends 1-2 from VS-5584, a Novel and Highly Selective PI3K/mTOR Kinase Inhibitor for the Treatment of Cancer
Authors: Hart Stefan , Novotny-Diermayr Veronica , Goh Kee Chuan , Williams Meredith , Tan Yong Cheng , Ong Lai Chun , Cheong Albert , Ng Bee Kheng , Amalini Chithra , Madan Babita , Nagaraj Harish , Jayaraman Ramesh , Pasha Khalid M. , Ethirajulu Kantharaj , Chng Wee Joo , Mustafa Nurulhuda , Goh Boon Cher , Benes Cyril , McDermott Ultan , Garnett Mathew , Dymock Brian , Wood Jeanette M.
Published: April 2023

PDF file - 2.9MB, In-vitro kinase assay, Histology, Cell proliferation, MANOVA analysis for genomic correlates of drug sensitivity
Supplementary Figures 1-5 from Crizotinib Induces PUMA-Dependent Apoptosis in Colon Cancer Cells
Authors: Zheng Xingnan , He Kan , Zhang Lin , Yu Jian
Published: April 2023

PDF file - 549 KB, Figure S1: Expression of Bcl-2 family proteins before and after crizotinib treatment; Figure S2: Crizotinib induces PUMA-dependent apoptosis; Figure S3: Crizotinib induces p53-dependent induction of PUMA and apoptosis in colon cancer cells; Figure S4: p65 or Foxo3a siRNA did not affect PUMA induction by crizotinib; Figure S5: Crizotinib and sorafenib synergize to induce PUMA-dependent apoptosis in colon cancer cells.
Supplementary Figure 2 from Cetuximab Reverses the Warburg Effect by Inhibiting HIF-1–Regulated LDH-A
Authors: Lu Haiquan , Li Xinqun , Luo Zhongguang , Liu Jie , Fan Zhen
Published: April 2023

PDF - 190KB, Combination of oxamate and cetuximab induces growth inhibition in cetuximab-resistant HNSCC cells.
Supplementary Figure 2 from Stromal Platelet-Derived Growth Factor Receptor α (PDGFRα) Provides a Therapeutic Target Independent of Tumor Cell PDGFRα Expression in Lung Cancer Xenografts
Authors: Gerber David E. , Gupta Puja , Dellinger Michael T. , Toombs Jason E. , Peyton Michael , Duignan Inga , Malaby Jennifer , Bailey Timothy , Burns Colleen , Brekken Rolf A. , Loizos Nick
Published: April 2023

PDF file, 156K, Species and target specificity of IMC-3G3 and 1E10.
Supplementary Figure 1 from Cetuximab Reverses the Warburg Effect by Inhibiting HIF-1–Regulated LDH-A
Authors: Lu Haiquan , Li Xinqun , Luo Zhongguang , Liu Jie , Fan Zhen
Published: April 2023

PDF - 218KB, Knockdown of LDH-A overcame resistance to cetuximab-induced cell cycle arrest.
Supplementary Figure 2 from Targeting CXCR2 Enhances Chemotherapeutic Response, Inhibits Mammary Tumor Growth, Angiogenesis, and Lung Metastasis
Authors: Sharma Bhawna , Nawandar Dhananjay M. , Nannuru Kalyan C. , Varney Michelle L. , Singh Rakesh K.
Published: April 2023

PDF file - 58K, Figure S2: Expression of CXCL8 in SKBR3 control and CXCR2 over-expressing cells after doxorubicin and paclitaxel treatment was determined using ELISA. Slight increase in the expression of CXCL8 in CXCR2 over-expressing cells but the change is not significant.
Supplementary Figure 1 from Combination of Pan-Histone Deacetylase Inhibitor and Autophagy Inhibitor Exerts Superior Efficacy against Triple-Negative Human Breast Cancer Cells
Authors: Rao Rekha , Balusu Ramesh , Fiskus Warren , Mudunuru Uma , Venkannagari Sreedhar , Chauhan Lata , Smith Jacqueline E. , Hembruff Stacey L. , Ha Kyungsoo , Atadja Peter , Bhalla Kapil N.
Published: April 2023

PDF file - 56K, Chemical structures of panobinostat and chloroquine.
Supplementary Figures 1 - 8 from Dual Systemic Tumor Targeting with Ligand-Directed Phage and Grp78 Promoter Induces Tumor Regression
Authors: Kia Azadeh , Przystal Justyna M. , Nianiaris Nastasia , Mazarakis Nicholas D. , Mintz Paul J. , Hajitou Amin
Published: April 2023

PDF file - 1273K, Supplementary Figure S1 - Design and construction of the double targeted RGD4C/Grp78 vector. Supplementary Figure S2 - The double targeted RGD4C/Grp78 vector mediates GFP expression in human HEK293 cells upon stress treatment. Supplementary Figure S3 - 9L tumor cells show higher proliferation rate, better survival, increased levels of endogenous Grp78 than the U87 cells, and express the spliced form of the mRNA of XBP1. Supplementary Figure S4 - Tumors developed in immunodeficient mice from 9L cells stably transduced with RGD4C/Grp78-Luc show better expression of the Luc reporter gene overtime than tumors-derived from RGD4C/CMV-Luc transduced 9L cells. Supplementary Figure S5 - U87 tumor cells transduced with RGD4C/Grp78-HSVtk vector show more cell death, upon GCV treatment, than cells transduced with RGD4C/CMV-HSVtk. Supplementary Figure S6 - RGD4C/Grp78 mediates efficient transgene expression and cell killing in transduced but non-selected 9L and U87 tumor cells. Supplementary Figure S7 - RGD4C/Grp78 mediates transgene expression in human breast cancer cells. Supplementary Figure S8 - The spliced XBP1 mRNA of 9L tumor cells is not induced by HSVtk expression and GCV.
Supplementary Figure Legend from Epithelial Tissue Hyperplasia Induced by the RAF Inhibitor PF-04880594 Is Attenuated by a Clinically Well-Tolerated Dose of the MEK Inhibitor PD-0325901
Authors: Torti Vince R. , Wojciechowicz Donald , Hu Wenyue , John-Baptiste Annette , Evering Winston , Troche Gabriel , Marroquin Lisa D. , Smeal Tod , Yamazaki Shinji , Palmer Cynthia L. , Burns-Naas Leigh Ann , Bagrodia Shubha
Published: April 2023

PDF file, 66K.
Supplementary Figure Legend from Dual Systemic Tumor Targeting with Ligand-Directed Phage and Grp78 Promoter Induces Tumor Regression
Authors: Kia Azadeh , Przystal Justyna M. , Nianiaris Nastasia , Mazarakis Nicholas D. , Mintz Paul J. , Hajitou Amin
Published: April 2023

PDF file - 136K
Supplementary Figure 3 from Epithelial Tissue Hyperplasia Induced by the RAF Inhibitor PF-04880594 Is Attenuated by a Clinically Well-Tolerated Dose of the MEK Inhibitor PD-0325901
Authors: Torti Vince R. , Wojciechowicz Donald , Hu Wenyue , John-Baptiste Annette , Evering Winston , Troche Gabriel , Marroquin Lisa D. , Smeal Tod , Yamazaki Shinji , Palmer Cynthia L. , Burns-Naas Leigh Ann , Bagrodia Shubha
Published: April 2023

PDF file, 141K, Photographs of canine muzzles showing skin flushing following PF-04880594 treatment.
Supplementary Figure 2 from Epithelial Tissue Hyperplasia Induced by the RAF Inhibitor PF-04880594 Is Attenuated by a Clinically Well-Tolerated Dose of the MEK Inhibitor PD-0325901
Authors: Torti Vince R. , Wojciechowicz Donald , Hu Wenyue , John-Baptiste Annette , Evering Winston , Troche Gabriel , Marroquin Lisa D. , Smeal Tod , Yamazaki Shinji , Palmer Cynthia L. , Burns-Naas Leigh Ann , Bagrodia Shubha
Published: April 2023

PDF file, 75K, Body weight changes in nude mice administered RAF inhibitor (PF-04880594) are maintained in mice co-treated with MEK inhibitor (PD-0325901).
Supplementary Table 1 from Dibenzophenanthridines as Inhibitors of Glutaminase C and Cancer Cell Proliferation
Authors: Katt William P. , Ramachandran Sekar , Erickson Jon W. , Cerione Richard A.
Published: April 2023

PDF file, 294KB, Complete list of compounds examined in the recombinant GAC assay, and % inhibition determined against the enzyme for each compound.
Supplementary Figure 3 from Dibenzophenanthridines as Inhibitors of Glutaminase C and Cancer Cell Proliferation
Authors: Katt William P. , Ramachandran Sekar , Erickson Jon W. , Cerione Richard A.
Published: April 2023

PDF file, 50KB, Time dependence of two compounds, 35 and 40, showing that their activity decreases when incubated with GAC for 10 or 20 minutes prior to beginning the enzymatic reaction in the assay.
Supplementary Table 4 from Gene Expression Profile in Response to Doxorubicin–Rapamycin Combined Treatment of HER-2–Overexpressing Human Mammary Epithelial Cell Lines
Authors: Trapé Adriana Priscila , Katayama Maria Lucia Hirata , Roela Rosimeire Aparecida , Brentani Helena , Ravacci Graziela Rosa , de Araujo Lima Leandro , Brentani Maria Mitzi
Published: April 2023

PDF file - 75K
Supplementary Figures 1 - 7 from The Dual Pathway Inhibitor Rigosertib Is Effective in Direct Patient Tumor Xenografts of Head and Neck Squamous Cell Carcinomas
Authors: Anderson Ryan T. , Keysar Stephen B. , Bowles Daniel W. , Glogowska Magdalena J. , Astling David P. , Morton J. Jason , Le Phuong , Umpierrez Adrian , Eagles-Soukup Justin , Gan Gregory N. , Vogler Brian W. , Sehrt Daniel , Takimoto Sarah M. , Aisner Dara L. , Wilhelm Francois , Frederick Barbara A. , Varella-Garcia Marileila , Tan Aik-Choon , Jimeno Antonio
Published: April 2023

PDF file - 956K, Supplementary Figure 1. A, Cellular viability of 6 sensitive and 5 resistant cell lines at 1.0μM rigosertib treatment as measured by SRB assay; Supplementary Figure 2. Proliferation of 2 rigosertib-sensitive (584 and HN11) and 2 rigosertib-resistant (MSK921 and UMSCC19) cell lines; Supplementary Figure 3. Western blot analysis of EGFR pathway activation in vitro in vehicle control (C), 1.0 μM rigosertib (R), and 1.0 μM ZSTK474 (Z) treated cultures; Supplementary Figure 4. A, Representative IHC of orthotopically xenografted HNSCC cell lines. B, Western blot analysis of EGFR pathway activation and representative IHC; Supplemental Figure 5. Graphical representation of tumor growth for the control (♦) and rigosertib (■) treatment groups from the sensitive CUHN026 (A) and resistant CUHN013 (B) tumor lines. Supplemental Figure 6. Western blot analysis of EGFR pathway activation in the control (C) and rigosertib (R) treated direct patient xenografted tissue; Supplemental Figure 7. Representative IHC from treated direct patient xenografted tissue.
Supplementary Table 2 from Gene Expression Profile in Response to Doxorubicin–Rapamycin Combined Treatment of HER-2–Overexpressing Human Mammary Epithelial Cell Lines
Authors: Trapé Adriana Priscila , Katayama Maria Lucia Hirata , Roela Rosimeire Aparecida , Brentani Helena , Ravacci Graziela Rosa , de Araujo Lima Leandro , Brentani Maria Mitzi
Published: April 2023

PDF file - 84K
Supplementary Figure 4 from Gene Expression Profile in Response to Doxorubicin–Rapamycin Combined Treatment of HER-2–Overexpressing Human Mammary Epithelial Cell Lines
Authors: Trapé Adriana Priscila , Katayama Maria Lucia Hirata , Roela Rosimeire Aparecida , Brentani Helena , Ravacci Graziela Rosa , de Araujo Lima Leandro , Brentani Maria Mitzi
Published: April 2023

PDF file - 1.3MB
Supplementary Figure 6 from Characterization of the Mechanism of Action of the Pan Class I PI3K Inhibitor NVP-BKM120 across a Broad Range of Concentrations
Authors: Brachmann Saskia M. , Kleylein-Sohn Julia , Gaulis Swann , Kauffmann Audrey , Blommers Marcel J.J. , Kazic-Legueux Malika , Laborde Laurent , Hattenberger Marc , Stauffer Fabian , Vaxelaire Juliane , Romanet Vincent , Henry Chrystèle , Murakami Masato , Guthy Daniel Alexander , Sterker Dario , Bergling Sebastian , Wilson Christopher , Brümmendorf Thomas , Fritsch Christine , Garcia-Echeverria Carlos , Sellers William R. , Hofmann Francesco , Maira Sauveur-Michel
Published: April 2023

PDF file, 107KB, A. 2.5x106 Rat1-myr-p110a (left) or U87MG cells were seeded in 10 cm dishes and exposed for 6h either to BKM120 (5 �M) or to the DMSO control. Cells were then lyzed and cell extracts were analyzed by Western-blot for PI3K pathway inhibition and G2/M markers as revealed by S473P-Akt (upper panel) and Ser10P-Histone H3 (bottom panel) levels, respectively. B. U87MG tumor bearing mice were treated orally, once per day for 6 days with BKM120 at the indicated doses. Tumor volumes were callipered and plotted. ns: not significant.
Supplementary Figure 4 from Characterization of the Mechanism of Action of the Pan Class I PI3K Inhibitor NVP-BKM120 across a Broad Range of Concentrations
Authors: Brachmann Saskia M. , Kleylein-Sohn Julia , Gaulis Swann , Kauffmann Audrey , Blommers Marcel J.J. , Kazic-Legueux Malika , Laborde Laurent , Hattenberger Marc , Stauffer Fabian , Vaxelaire Juliane , Romanet Vincent , Henry Chrystèle , Murakami Masato , Guthy Daniel Alexander , Sterker Dario , Bergling Sebastian , Wilson Christopher , Brümmendorf Thomas , Fritsch Christine , Garcia-Echeverria Carlos , Sellers William R. , Hofmann Francesco , Maira Sauveur-Michel
Published: April 2023

PDF file, 653KB, MDA-MB231 (left) and U87MG (right) cells grown on coverslips were treated for 24 h either with BKM120 (5 μM) or Nocodazole (100 nM) and the effects of compound treatment on microtubule dynamics and G2/M arrest was monitored by immuno-fluorescence staining of alpha-tubulin (microtubules), gamma tubulin (centrosomes) and DAPI (DNA). Pictures were taken with a 100X objective.
Supplementary Figure 1 from Gene Expression Profile in Response to Doxorubicin–Rapamycin Combined Treatment of HER-2–Overexpressing Human Mammary Epithelial Cell Lines
Authors: Trapé Adriana Priscila , Katayama Maria Lucia Hirata , Roela Rosimeire Aparecida , Brentani Helena , Ravacci Graziela Rosa , de Araujo Lima Leandro , Brentani Maria Mitzi
Published: April 2023

PDF file - 255K
Supplementary Figure 2 from Characterization of the Mechanism of Action of the Pan Class I PI3K Inhibitor NVP-BKM120 across a Broad Range of Concentrations
Authors: Brachmann Saskia M. , Kleylein-Sohn Julia , Gaulis Swann , Kauffmann Audrey , Blommers Marcel J.J. , Kazic-Legueux Malika , Laborde Laurent , Hattenberger Marc , Stauffer Fabian , Vaxelaire Juliane , Romanet Vincent , Henry Chrystèle , Murakami Masato , Guthy Daniel Alexander , Sterker Dario , Bergling Sebastian , Wilson Christopher , Brümmendorf Thomas , Fritsch Christine , Garcia-Echeverria Carlos , Sellers William R. , Hofmann Francesco , Maira Sauveur-Michel
Published: April 2023

PDF file, 300KB, A. Upon infection with viral particles obtained from the pBabe-puro-myr-Akt retroviral vectors, pools were selected upon addition of puromycin and maintained in culture for several weeks. Extracts from pools were generated for the indicated time of culture and analyzed by Western-blot for the expression of the exogenously expressed HA-tagged form of the dominant active myr-Akt protein. B. 2.5x106 MCF7-BP (upper panel) or MCF7-myr-Akt (bottom panel) were seeded in 10 cm dishes and exposed for 1 h to the indicated compounds at the indicated concentrations (in nM). Cells were then lyzed and cell extracts were analyzed by Western-blot for pathway inhibition as revealed by S473P-Akt levels.
Supplementary Figure 6 from Dual Programmed Cell Death Pathways Induced by p53 Transactivation Overcome Resistance to Oncolytic Adenovirus in Human Osteosarcoma Cells
Authors: Hasei Joe , Sasaki Tsuyoshi , Tazawa Hiroshi , Osaki Shuhei , Yamakawa Yasuaki , Kunisada Toshiyuki , Yoshida Aki , Hashimoto Yuuri , Onishi Teppei , Uno Futoshi , Kagawa Shunsuke , Urata Yasuo , Ozaki Toshifumi , Fujiwara Toshiyoshi
Published: April 2023

PDF file - 852K, Immunohistochemistry of MNNG/HOS tumors
Supplementary Figure 5 from Dual Programmed Cell Death Pathways Induced by p53 Transactivation Overcome Resistance to Oncolytic Adenovirus in Human Osteosarcoma Cells
Authors: Hasei Joe , Sasaki Tsuyoshi , Tazawa Hiroshi , Osaki Shuhei , Yamakawa Yasuaki , Kunisada Toshiyuki , Yoshida Aki , Hashimoto Yuuri , Onishi Teppei , Uno Futoshi , Kagawa Shunsuke , Urata Yasuo , Ozaki Toshifumi , Fujiwara Toshiyoshi
Published: April 2023

PDF file - 261K, Chronological change of p21 expression in SaOS-2 cells after Ad-p53 infection
Supplementary Figure 4 from Dual Programmed Cell Death Pathways Induced by p53 Transactivation Overcome Resistance to Oncolytic Adenovirus in Human Osteosarcoma Cells
Authors: Hasei Joe , Sasaki Tsuyoshi , Tazawa Hiroshi , Osaki Shuhei , Yamakawa Yasuaki , Kunisada Toshiyuki , Yoshida Aki , Hashimoto Yuuri , Onishi Teppei , Uno Futoshi , Kagawa Shunsuke , Urata Yasuo , Ozaki Toshifumi , Fujiwara Toshiyoshi
Published: April 2023

PDF file - 213K, Quantitative measurement of viral DNA replication in SaOS-2 cells infected with OBP-702 or OBP-301
Supplementary Figure 4 from Low Levels of Circulating Estrogen Sensitize PTEN-Null Endometrial Tumors to PARP Inhibition In Vivo
Authors: Janzen Deanna M. , Paik Daniel Y. , Rosales Miguel A. , Yep Brian , Cheng Donghui , Witte Owen N. , Kayadibi Huseyin , Ryan Christopher M. , Jung Michael E. , Faull Kym , Memarzadeh Sanaz
Published: April 2023

PDF file - 139K, Figure S4. Three-dimensional in vitro model for growth and treatment of PTEN-null epithelia co-cultured with WT endometrial stroma.
Supplementary Figure 2 from Dual Programmed Cell Death Pathways Induced by p53 Transactivation Overcome Resistance to Oncolytic Adenovirus in Human Osteosarcoma Cells
Authors: Hasei Joe , Sasaki Tsuyoshi , Tazawa Hiroshi , Osaki Shuhei , Yamakawa Yasuaki , Kunisada Toshiyuki , Yoshida Aki , Hashimoto Yuuri , Onishi Teppei , Uno Futoshi , Kagawa Shunsuke , Urata Yasuo , Ozaki Toshifumi , Fujiwara Toshiyoshi
Published: April 2023

PDF file - 334K, The ID50 values of OBP-702 and Ad-p53 in SaOS-2 and MNNG/HOS cells
Supplementary Figure 2 from Low Levels of Circulating Estrogen Sensitize PTEN-Null Endometrial Tumors to PARP Inhibition In Vivo
Authors: Janzen Deanna M. , Paik Daniel Y. , Rosales Miguel A. , Yep Brian , Cheng Donghui , Witte Owen N. , Kayadibi Huseyin , Ryan Christopher M. , Jung Michael E. , Faull Kym , Memarzadeh Sanaz
Published: April 2023

PDF file - 409K, Figure S2. The histology of Olaparib treated estrogen deprived PTEN-null tumors was similar to vehicle treated counterparts and resembled human endometrioid endometrial carcinoma.
Supplementary Figures 1-5 from The Efficacy of CHK1 Inhibitors Is Not Altered by Hypoxia, but Is Enhanced after Reoxygenation
Authors: Hasvold Grete , Nähse-Kumpf Viola , Tkacz-Stachowska Kinga , Rofstad Einar K. , Syljuåsen Randi G.
Published: April 2023

PDF - 491K, Supplementary Figure S1: Cell cycle progression following hypoxia treatment. Supplementary Figure S2: Clonogenic survival following depletion of CHK1 by siRNA transfection. Supplementary Figure S3: S phase damage in HCT116p53-/- and HT29 cells in response to CHK1- inhibition after reoxygenation. Supplementary Figure S4: EdU uptake in U2OS cells treated with UCN-01 after reoxygenation. Supplementary Figure S5: Clonogenic survial of U2OS cells treated with IR and UCN-01 after reoxygenation following prolonged hypoxia.
Supplementary Figure Legends from The Efficacy of CHK1 Inhibitors Is Not Altered by Hypoxia, but Is Enhanced after Reoxygenation
Authors: Hasvold Grete , Nähse-Kumpf Viola , Tkacz-Stachowska Kinga , Rofstad Einar K. , Syljuåsen Randi G.
Published: April 2023

PDF - 35K
Supplementary Figure 1 from Antitumor Effect of SIRT1 Inhibition in Human HCC Tumor Models In Vitro and In Vivo
Authors: Portmann Simone , Fahrner René , Lechleiter Antje , Keogh Adrian , Overney Sarah , Laemmle Alexander , Mikami Kei , Montani Matteo , Tschan Mario P. , Candinas Daniel , Stroka Deborah
Published: April 2023

PDF file - 54K, SIRT2-7 expression in HCC cell lines
Supplementary Methods and Figure Legends from Chemosensitization of Cancer Cells by KU-0060648, a Dual Inhibitor of DNA-PK and PI-3K
Authors: Munck Joanne M. , Batey Michael A. , Zhao Yan , Jenkins Helen , Richardson Caroline J. , Cano Celine , Tavecchio Michele , Barbeau Jody , Bardos Julia , Cornell Liam , Griffin Roger J. , Menear Keith , Slade Andrew , Thommes Pia , Martin Niall M.B. , Newell David R. , Smith Graeme C.M. , Curtin Nicola J.
Published: April 2023

PDF file, 112KB.
Supplementary Tables 1 - 2 from miR-148b Functions as a Tumor Suppressor in Pancreatic Cancer by Targeting AMPKα1
Authors: Zhao Gang , Zhang Jun-Gang , Liu Yang , Qin Qi , Wang Bo , Tian Kui , Liu Lin , Li Xiang , Niu Yi , Deng Shi-Chang , Wang Chun-You
Published: April 2023

PDF file - 57K, Supplemental Table S1. Sequences of qRT-PCR primers. Supplemental Table S2. Sequences of RNA oligonucleotides.
Supplementary Figure Legend from miR-148b Functions as a Tumor Suppressor in Pancreatic Cancer by Targeting AMPKα1
Authors: Zhao Gang , Zhang Jun-Gang , Liu Yang , Qin Qi , Wang Bo , Tian Kui , Liu Lin , Li Xiang , Niu Yi , Deng Shi-Chang , Wang Chun-You
Published: April 2023

PDF file - 111K
Supplementary Figure 5 from miR-148b Functions as a Tumor Suppressor in Pancreatic Cancer by Targeting AMPKα1
Authors: Zhao Gang , Zhang Jun-Gang , Liu Yang , Qin Qi , Wang Bo , Tian Kui , Liu Lin , Li Xiang , Niu Yi , Deng Shi-Chang , Wang Chun-You
Published: April 2023

PDF file - 2958K, Figure S5. Downregulation of AMPKα1 increases apoptosis and cell cycle arrest and inhibits invasion of pancreatic cancer cells.
Supplementary Figure Legends from Spongian Diterpenoids Inhibit Androgen Receptor Activity
Authors: Yang Yu Chi , Meimetis Labros G. , Tien Amy H. , Mawji Nasrin R. , Carr Gavin , Wang Jun , Andersen Raymond J. , Sadar Marianne D.
Published: April 2023

PDF - 121K, Methods and Supplemental Figure Legends and References
Supplementary Figure 3 from Spongian Diterpenoids Inhibit Androgen Receptor Activity
Authors: Yang Yu Chi , Meimetis Labros G. , Tien Amy H. , Mawji Nasrin R. , Carr Gavin , Wang Jun , Andersen Raymond J. , Sadar Marianne D.
Published: April 2023

PDF File - 72K, Reporter gene assay and growth assay of LNCaP95 cells.
Supplementary Figure 1 from Spongian Diterpenoids Inhibit Androgen Receptor Activity
Authors: Yang Yu Chi , Meimetis Labros G. , Tien Amy H. , Mawji Nasrin R. , Carr Gavin , Wang Jun , Andersen Raymond J. , Sadar Marianne D.
Published: April 2023

PDF File - 58K, PC3 cell proliferation data.
Supplementary Methods from Small-Molecule Inhibitors of USP1 Target ID1 Degradation in Leukemic Cells
Authors: Mistry Helena , Hsieh Grace , Buhrlage Sara J. , Huang Min , Park Eunmi , Cuny Gregory D. , Galinsky Ilene , Stone Richard M. , Gray Nathanael S. , D'Andrea Alan D. , Parmar Kalindi
Published: April 2023

PDF - 86KB, Additional supplementary methods.
Supplementary Figures 1 through 6 from Small-Molecule Inhibitors of USP1 Target ID1 Degradation in Leukemic Cells
Authors: Mistry Helena , Hsieh Grace , Buhrlage Sara J. , Huang Min , Park Eunmi , Cuny Gregory D. , Galinsky Ilene , Stone Richard M. , Gray Nathanael S. , D'Andrea Alan D. , Parmar Kalindi
Published: April 2023

PDF - 502KB, Supplementary figure 1. USP1 inhibitor SJB2-043 inhibits activity of native USP1 in a dose-dependent manner and causes a decrease in ID1, ID2 and ID3 levels in K562 cells. Supplementary figure 2. Knockdown of USP1 results in growth inhibition, increased apoptosis and cell cycle arrest in K562 cells. Supplementary figure 3. Analogs of USP1 inhibitor lead to ID1 destabilization in leukemic cells. Supplementary figure 4. Caspase inhibitor does not block the degradation of ID1 by USP1 inhibitors. Supplementary figure 5. Effects of USP1 inhibitors on growth of primary human cord blood CD34+ cells. Supplementary figure 6. USP1 inhibitors cause increase in Ub-FANCD2, Ub-PCNA, and p21, and decrease the HR activity.
Supplementary Figure Legend from Antitumor Activity of Src Inhibitor Saracatinib (AZD-0530) in Preclinical Models of Biliary Tract Carcinomas
Authors: Cavalloni Giuliana , Peraldo-Neia Caterina , Sarotto Ivana , Gammaitoni Loretta , Migliardi Giorgia , Soster Marco , Marchiò Serena , Aglietta Massimo , Leone Francesco
Published: April 2023

PDF file, 76KB.
Supplementary Figure 4 from Antitumor Activity of Src Inhibitor Saracatinib (AZD-0530) in Preclinical Models of Biliary Tract Carcinomas
Authors: Cavalloni Giuliana , Peraldo-Neia Caterina , Sarotto Ivana , Gammaitoni Loretta , Migliardi Giorgia , Soster Marco , Marchiò Serena , Aglietta Massimo , Leone Francesco
Published: April 2023

PDF file, 9KB, Inhibition of cellular foci formation: Saracatinib had the ability to reduce the formation of cellular foci in all the cell lines at Dm of 1 μM after 72 hours of treatment.
Supplementary Figure 5 from Cotargeting MAPK and PI3K Signaling with Concurrent Radiotherapy as a Strategy for the Treatment of Pancreatic Cancer
Authors: Williams Terence M. , Flecha Athena R. , Keller Paul , Ram Ashwin , Karnak David , Galbán Stefanie , Galbán Craig J. , Ross Brian D. , Lawrence Theodore S. , Rehemtulla Alnawaz , Sebolt-Leopold Judith
Published: April 2023

PDF file, 48KB, Changes in MRI tumor volume for mice treated with radiation alone, API-2, or radiation with API-2. There was no radiosensitization observed with API-2 in the absence of a MEK inhibitor.
Supplementary Figure 2 from Antitumor Activity of Src Inhibitor Saracatinib (AZD-0530) in Preclinical Models of Biliary Tract Carcinomas
Authors: Cavalloni Giuliana , Peraldo-Neia Caterina , Sarotto Ivana , Gammaitoni Loretta , Migliardi Giorgia , Soster Marco , Marchiò Serena , Aglietta Massimo , Leone Francesco
Published: April 2023

PDF file, 9KB, Basal activated Src expression in BTC cell lines.
Supplementary Figure 1 from Antitumor Activity of Src Inhibitor Saracatinib (AZD-0530) in Preclinical Models of Biliary Tract Carcinomas
Authors: Cavalloni Giuliana , Peraldo-Neia Caterina , Sarotto Ivana , Gammaitoni Loretta , Migliardi Giorgia , Soster Marco , Marchiò Serena , Aglietta Massimo , Leone Francesco
Published: April 2023

PDF file, 11KB, Representative images of p-Src expression in BTC case series. A: Negative control. B-C-D: p-Src expression scored 1+, 2+ and 3+ respectively.
Supplementary Table 1 from Quantitative Chemical Proteomics Profiling Differentiates Erlotinib from Gefitinib in EGFR Wild-Type Non–Small Cell Lung Carcinoma Cell Lines
Authors: Augustin Angélique , Lamerz Jens , Meistermann Hélène , Golling Sabrina , Scheiblich Stefan , Hermann Johannes C. , Duchateau-Nguyen Guillemette , Tzouros Manuel , Avila David W. , Langen Hanno , Essioux Laurent , Klughammer Barbara
Published: April 2023

XLSX file - 144K, Protein identifications in eluted fractions from erlotinib-Sepharose and gefitinib-Sepharose
Supplementary Figure 1 from A Highly Potent and Specific MET Therapeutic Protein Antagonist with Both Ligand-Dependent and Ligand-Independent Activity
Authors: Olwill Shane A. , Joffroy Christian , Gille Hendrik , Vigna Elisa , Matschiner Gabriele , Allersdorfer Andrea , Lunde Bradley M. , Jaworski Jakub , Burrows James F. , Chiriaco Cristina , Christian Hans Jürgen , Hülsmeyer Martin , Trentmann Stefan , Jensen Kristian , Hohlbaum Andreas M. , Audoly Laurent
Published: April 2023

PDF - 31KB, Characterisation of cell line panel for MET and HGF expression
Supplementary Methods from Quantitative Chemical Proteomics Profiling Differentiates Erlotinib from Gefitinib in EGFR Wild-Type Non–Small Cell Lung Carcinoma Cell Lines
Authors: Augustin Angélique , Lamerz Jens , Meistermann Hélène , Golling Sabrina , Scheiblich Stefan , Hermann Johannes C. , Duchateau-Nguyen Guillemette , Tzouros Manuel , Avila David W. , Langen Hanno , Essioux Laurent , Klughammer Barbara
Published: April 2023

PDF file - 96K
Supplementary Figure 2 from Quantitative Chemical Proteomics Profiling Differentiates Erlotinib from Gefitinib in EGFR Wild-Type Non–Small Cell Lung Carcinoma Cell Lines
Authors: Augustin Angélique , Lamerz Jens , Meistermann Hélène , Golling Sabrina , Scheiblich Stefan , Hermann Johannes C. , Duchateau-Nguyen Guillemette , Tzouros Manuel , Avila David W. , Langen Hanno , Essioux Laurent , Klughammer Barbara
Published: April 2023

XLSX file - 24K, Statistics of proteins that significantly decrease in their relative abundance with increasing compound concentration, in at least one of the two compounds
Supplementary Figure 1 from The Inhibitor of Histone Deacetylases Sodium Butyrate Enhances the Cytotoxicity of Mitomycin C
Authors: Gospodinov Anastas , Popova Stanislava , Vassileva Ivelina , Anachkova Boyka
Published: April 2023

PDF file - 1.2MB
Supplementary Tables 1 - 2 from In Silico Screening Reveals Structurally Diverse, Nanomolar Inhibitors of NQO2 That Are Functionally Active in Cells and Can Modulate NF-κB Signaling
Authors: Nolan Karen A. , Dunstan Mark S. , Caraher Mary C. , Scott Katherine A. , Leys David , Stratford Ian J.
Published: April 2023

PDF file - 162KB
Supplementary Figure 3 from Bortezomib and SAHA Synergistically Induce ROS-Driven Caspase-Dependent Apoptosis of Nasopharyngeal Carcinoma and Block Replication of Epstein–Barr Virus
Authors: Hui Kwai Fung , Lam Benjamin H.W. , Ho Dona N. , Tsao Sai Wah , Chiang Alan K.S.
Published: April 2023

PDF File - 487K, Effects of bortezomib/SAHA on EBV-negative and EBV-positive NPC cells.
Supplementary Video Legend from Preclinical Activity of the Type II CD20 Antibody GA101 (Obinutuzumab) Compared with Rituximab and Ofatumumab In Vitro and in Xenograft Models
Authors: Herter Sylvia , Herting Frank , Mundigl Olaf , Waldhauer Inja , Weinzierl Tina , Fauti Tanja , Muth Gunter , Ziegler-Landesberger Doris , Van Puijenbroek Erwin , Lang Sabine , Duong Minh Ngoc , Reslan Lina , Gerdes Christian A. , Friess Thomas , Baer Ute , Burtscher Helmut , Weidner Michael , Dumontet Charles , Umana Pablo , Niederfellner Gerhard , Bacac Marina , Klein Christian
Published: April 2023

PDF file - 39K
Supplementary Figure 2 from Bortezomib and SAHA Synergistically Induce ROS-Driven Caspase-Dependent Apoptosis of Nasopharyngeal Carcinoma and Block Replication of Epstein–Barr Virus
Authors: Hui Kwai Fung , Lam Benjamin H.W. , Ho Dona N. , Tsao Sai Wah , Chiang Alan K.S.
Published: April 2023

PDF File - 2531K, Effects of bortezomib/SAHA on expression of tumor suppressor genes.
Supplementary Figure Legend from Antitumor Action of the MET Tyrosine Kinase Inhibitor Crizotinib (PF-02341066) in Gastric Cancer Positive for MET Amplification
Authors: Okamoto Wataru , Okamoto Isamu , Arao Tokuzo , Kuwata Kiyoko , Hatashita Erina , Yamaguchi Haruka , Sakai Kazuko , Yanagihara Kazuyoshi , Nishio Kazuto , Nakagawa Kazuhiko
Published: April 2023

PDF file, 94KB.
Supplementary Figure 3 from Antitumor Action of the MET Tyrosine Kinase Inhibitor Crizotinib (PF-02341066) in Gastric Cancer Positive for MET Amplification
Authors: Okamoto Wataru , Okamoto Isamu , Arao Tokuzo , Kuwata Kiyoko , Hatashita Erina , Yamaguchi Haruka , Sakai Kazuko , Yanagihara Kazuyoshi , Nishio Kazuto , Nakagawa Kazuhiko
Published: April 2023

PDF file, 126KB, Effects of crizotinib on the growth of gastric cancer cells in vivo.
Supplementary Figure 2 from Antitumor Action of the MET Tyrosine Kinase Inhibitor Crizotinib (PF-02341066) in Gastric Cancer Positive for MET Amplification
Authors: Okamoto Wataru , Okamoto Isamu , Arao Tokuzo , Kuwata Kiyoko , Hatashita Erina , Yamaguchi Haruka , Sakai Kazuko , Yanagihara Kazuyoshi , Nishio Kazuto , Nakagawa Kazuhiko
Published: April 2023

PDF file, 138KB, Effects of crizotinib on cell cycle distribution in gastric cancer cells with MET amplification.
Supplementary Figure Legends from Modulation of p53 C-Terminal Acetylation by mdm2, p14ARF, and Cytoplasmic SirT2
Authors: van Leeuwen Ingeborg M.M. , Higgins Maureen , Campbell Johanna , McCarthy Anna R. , Sachweh Marijke C.C. , Navarro Ana Marín , Laín Sonia
Published: April 2023

PDF file - 105K
Supplementary Figure 1 from Modulation of p53 C-Terminal Acetylation by mdm2, p14ARF, and Cytoplasmic SirT2
Authors: van Leeuwen Ingeborg M.M. , Higgins Maureen , Campbell Johanna , McCarthy Anna R. , Sachweh Marijke C.C. , Navarro Ana Marín , Laín Sonia
Published: April 2023

PDF file - 227K, Hdm2 promotes the binding of acetylated p53 to chromatin when p14ARF is present
Supplementary Figure 4 from HER2-Targeted Hybrid Peptide That Blocks HER2 Tyrosine Kinase Disintegrates Cancer Cell Membrane and Inhibits Tumor Growth In Vivo
Authors: Kawamoto Megumi , Horibe Tomohisa , Kohno Masayuki , Kawakami Koji
Published: April 2023

PDF file - 56 KB, Effect of Her2-lytic hybrid peptide on cell viability of H9c2 cells. H9c2 cells were cultured with various concentrations of HER2-lytic hybrid peptide as indicated for 72 h, and cell viability was assessed using WST-8 reagent as described in Materials and Methods section.
Supplementary Methods from Novel Inhibitors of Rad6 Ubiquitin Conjugating Enzyme: Design, Synthesis, Identification, and Functional Characterization
Authors: Sanders Matthew A. , Brahemi Ghali , Nangia-Makker Pratima , Balan Vitaly , Morelli Matteo , Kothayer Hend , Westwell Andrew D. , Shekhar Malathy P.V.
Published: April 2023

PDF file - 109K
Supplementary Figure 3 from HER2-Targeted Hybrid Peptide That Blocks HER2 Tyrosine Kinase Disintegrates Cancer Cell Membrane and Inhibits Tumor Growth In Vivo
Authors: Kawamoto Megumi , Horibe Tomohisa , Kohno Masayuki , Kawakami Koji
Published: April 2023

PDF file - 39 KB, Cell viability of breast cancer cell lines treated with HER2-lytic hybrid peptide at half the IC50 dose for 3 h. Breast cancer cell lines were treated with HER2-lytic hybrid peptide for 3 h at half the IC50 dose (SK-BR-3, 3.0 ��M; BT-474, 4.0 ��M; MDA-MB-361, 4.0 ��M; MDA-MB-453, 2.1 ��M; MDA-MB-231, 4.5 ��M). The viability of these cells was measured using WST-8 solution.
Supplementary Figure 2 from HER2-Targeted Hybrid Peptide That Blocks HER2 Tyrosine Kinase Disintegrates Cancer Cell Membrane and Inhibits Tumor Growth In Vivo
Authors: Kawamoto Megumi , Horibe Tomohisa , Kohno Masayuki , Kawakami Koji
Published: April 2023

PDF file - 41 KB, Effect of HER2 binding peptide on breast cancer cell lines. Cells were seeded onto 96-well plates at 3�~103 cells per well and incubated for 24 h. The cells were then incubated with increasing concentrations of the HER2-binding peptide for 3 h. Cell viability was measured using WST-8 solution.
Supplementary Table 1 from Targeting IGF-IR with Ganitumab Inhibits Tumorigenesis and Increases Durability of Response to Androgen-Deprivation Therapy in VCaP Prostate Cancer Xenografts
Authors: Fahrenholtz Cale D. , Beltran Pedro J. , Burnstein Kerry L.
Published: April 2023

PDF file - 41K, Table of weights of mice from VCaP and 22Rv1 xenograft studies
Supplementary Figure Legend from Targeting IGF-IR with Ganitumab Inhibits Tumorigenesis and Increases Durability of Response to Androgen-Deprivation Therapy in VCaP Prostate Cancer Xenografts
Authors: Fahrenholtz Cale D. , Beltran Pedro J. , Burnstein Kerry L.
Published: April 2023

PDF file - 94K
Supplementary Figure 2 from Targeting IGF-IR with Ganitumab Inhibits Tumorigenesis and Increases Durability of Response to Androgen-Deprivation Therapy in VCaP Prostate Cancer Xenografts
Authors: Fahrenholtz Cale D. , Beltran Pedro J. , Burnstein Kerry L.
Published: April 2023

PDF file - 151K, Evaluation of AR and ARΔLBD in androgen-dependent VCaP xenografts, castration-resistant VCaP xenografts, and castration-resistant 22Rv1 xenografts
Supplementary Figure 8 from ATP Citrate Lyase Knockdown Induces Growth Arrest and Apoptosis through Different Cell- and Environment-Dependent Mechanisms
Authors: Zaidi Nousheen , Royaux Ines , Swinnen Johannes V. , Smans Karine
Published: April 2023

PDF file, 137KB, Growth curves for PC3M cells with/without simvastatin and/or oleic acid supplementation.
Supplementary Figure Legends 1-2 from Cooperation between c-Met and Focal Adhesion Kinase Family Members in Medulloblastoma and Implications for Therapy
Authors: Guessous Fadila , Yang Yanzhi , Johnson Elizabeth , Marcinkiewicz Lukasz , Smith Matthew , Zhang Ying , Kofman Alexander , Schiff David , Christensen James , Abounader Roger
Published: April 2023

PDF file - 58K
Supplementary Figure 5 from ATP Citrate Lyase Knockdown Induces Growth Arrest and Apoptosis through Different Cell- and Environment-Dependent Mechanisms
Authors: Zaidi Nousheen , Royaux Ines , Swinnen Johannes V. , Smans Karine
Published: April 2023

PDF file, 59KB, Growth curves for ACLY-knockdown population of PC3M cells with/without Geranylgeranyl pyrophosphate (GGPP) supplementation.
Supplementary Figure 2 from Cooperation between c-Met and Focal Adhesion Kinase Family Members in Medulloblastoma and Implications for Therapy
Authors: Guessous Fadila , Yang Yanzhi , Johnson Elizabeth , Marcinkiewicz Lukasz , Smith Matthew , Zhang Ying , Kofman Alexander , Schiff David , Christensen James , Abounader Roger
Published: April 2023

PDF file - 411K
Supplementary Figure 4 from ATP Citrate Lyase Knockdown Induces Growth Arrest and Apoptosis through Different Cell- and Environment-Dependent Mechanisms
Authors: Zaidi Nousheen , Royaux Ines , Swinnen Johannes V. , Smans Karine
Published: April 2023

PDF file, 48KB, Induction of apoptosis in HOP62 and HepG2 cells after ACLY silencing.
Supplementary Table 2 from Berbamine Inhibits the Growth of Liver Cancer Cells and Cancer-Initiating Cells by Targeting Ca2+/Calmodulin-Dependent Protein Kinase II
Authors: Meng Zhipeng , Li Tao , Ma Xiaoxiao , Wang Xiaoqiong , Van Ness Carl , Gan Yichao , Zhou Hong , Tang Jinfen , Lou Guiyu , Wang Yafan , Wu Jun , Yen Yun , Xu Rongzhen , Huang Wendong
Published: April 2023

XLSX file, 11K, Sphere formation (2 independent trials).
Supplementary Figure 1 from MEDI0639: A Novel Therapeutic Antibody Targeting Dll4 Modulates Endothelial Cell Function and Angiogenesis In Vivo
Authors: Jenkins David W. , Ross Sarah , Veldman-Jones Margaret , Foltz Ian N. , Clavette Brandon C. , Manchulenko Kathy , Eberlein Cath , Kendrew Jane , Petteruti Philip , Cho Song , Damschroder Melissa , Peng Li , Baker Dawn , Smith Neil R. , Weir Hazel M. , Blakey David C. , Bedian Vahe , Barry Simon T.
Published: April 2023

PDF file - 153K, Figure to support screening for antibodies
Supplementary Figure 1 from The Antidiabetic Drug Metformin Inhibits Gastric Cancer Cell Proliferation In Vitro and In Vivo
Authors: Kato Kiyohito , Gong Jian , Iwama Hisakazu , Kitanaka Akira , Tani Joji , Miyoshi Hisaaki , Nomura Kei , Mimura Shima , Kobayashi Mitsuyoshi , Aritomo Yuuichi , Kobara Hideyuki , Mori Hirohito , Himoto Takashi , Okano Keiichi , Suzuki Yasuyuki , Murao Koji , Masaki Tsutomu
Published: April 2023

PDF file - 87K, Metformin structure.
Supplementary Table 1 from Glycolytic Inhibition Alters Anaplastic Thyroid Carcinoma Tumor Metabolism and Improves Response to Conventional Chemotherapy and Radiation
Authors: Sandulache Vlad C. , Skinner Heath D. , Wang Yuan , Chen Yunyun , Dodge Cristina T. , Ow Thomas J. , Bankson James A. , Myers Jeffrey N. , Lai Stephen Y.
Published: April 2023

PDF file, 2343KB.
Supplementary Table 3 from SAR131675, a Potent and Selective VEGFR-3–TK Inhibitor with Antilymphangiogenic, Antitumoral, and Antimetastatic Activities
Authors: Alam Antoine , Blanc Isabelle , Gueguen-Dorbes Geneviève , Duclos Olivier , Bonnin Jacques , Barron Pauline , Laplace Marie-Claude , Morin Gaelle , Gaujarengues Florence , Dol Frédérique , Hérault Jean-Pascal , Schaeffer Paul , Savi Pierre , Bono Françoise
Published: April 2023

PDF file - 55K, This file shows the results obtained with SAR131675 on the in vitro proliferation of a panel of tumor cell lines and on normal human dermal fibroblasts and PBLs
Supplementary Table 2 from A Human Single-Domain Antibody Elicits Potent Antitumor Activity by Targeting an Epitope in Mesothelin Close to the Cancer Cell Surface
Authors: Tang Zhewei , Feng Mingqian , Gao Wei , Phung Yen , Chen Weizao , Chaudhary Amit , Croix Brad St. , Qian Min , Dimitrov Dimiter S. , Ho Mitchell
Published: April 2023

PDF file - 57K, The number of mesothelin sites per cell on cancer cell lines.
Supplementary Figure 4 from SAR131675, a Potent and Selective VEGFR-3–TK Inhibitor with Antilymphangiogenic, Antitumoral, and Antimetastatic Activities
Authors: Alam Antoine , Blanc Isabelle , Gueguen-Dorbes Geneviève , Duclos Olivier , Bonnin Jacques , Barron Pauline , Laplace Marie-Claude , Morin Gaelle , Gaujarengues Florence , Dol Frédérique , Hérault Jean-Pascal , Schaeffer Paul , Savi Pierre , Bono Françoise
Published: April 2023

PDF file - 58K, Antitumoral and anti-metastatic effects of Sunitinib on a murine mammary carcinoma model in the absence or following primary tumor resection
Supplementary Methods from A Human Single-Domain Antibody Elicits Potent Antitumor Activity by Targeting an Epitope in Mesothelin Close to the Cancer Cell Surface
Authors: Tang Zhewei , Feng Mingqian , Gao Wei , Phung Yen , Chen Weizao , Chaudhary Amit , Croix Brad St. , Qian Min , Dimitrov Dimiter S. , Ho Mitchell
Published: April 2023

PDF file - 94K
Supplementary Figure 2 from A Role for Homologous Recombination and Abnormal Cell-Cycle Progression in Radioresistance of Glioma-Initiating Cells
Authors: Lim Yi Chieh , Roberts Tara L. , Day Bryan W. , Harding Angus , Kozlov Sergei , Kijas Amanda W. , Ensbey Kathleen S. , Walker David G. , Lavin Martin F.
Published: April 2023

PDF file, 388K, Glioma initiating cells are capable of forming different lineages.