bluuebunny/crossref_metadata_2025 huggingface dataset:
Promoting youth mental health during the COVID-19 pandemic: A longitudinal study
Authors: Rosen Maya L. , Rodman Alexandra M. , Kasparek Steven W. , Mayes Makeda , Freeman Malila M. , Lengua Liliana J. , Meltzoff Andrew N. , McLaughlin Katie A.
Published: August 2021

The COVID-19 pandemic has introduced novel stressors into the lives of youth. Identifying factors that protect against the onset of psychopathology in the face of these stressors is critical. We examine a wide range of factors that may protect youth from developing psychopathology during the pandemic. We assessed pandemic-related stressors, internalizing and externalizing psychopathology, and potential protective factors by combining two longitudinal samples of children and adolescents (N = 224, 7–10 and 13–15 years) assessed prior to the pandemic, during the stay-at-home orders, and six months later. We evaluated how family behaviors during the stay-at-home orders were related to changes in psychopathology during the pandemic, identified factors that moderate the association of pandemic-related stressors with psychopathology, and determined whether associations varied by age. Internalizing and externalizing psychopathology increased substantially during the pandemic. Higher exposure to pandemic-related stressors was associated with increases in internalizing and externalizing symptoms early in the pandemic and six months later. Having a structured routine, less passive screen time, lower exposure to news media about the pandemic, and to a lesser extent more time in nature and getting adequate sleep were associated with reduced psychopathology. The association between pandemic-related stressors and psychopathology was reduced for youths with limited passive screen time and was absent for children, but not adolescents, with lower news media consumption related to the pandemic. We provide insight into simple, practical steps families can take to promote resilience against mental health problems in youth during the COVID-19 pandemic and protect against psychopathology following pandemic-related stressors.
Coral reefs in the Gilbert Islands of Kiribati: Resistance, resilience, and recovery after more than a decade of multiple stressors
Authors: Cannon Sara E. , Aram Erietera , Beiateuea Toaea , Kiareti Aranteiti , Peter Max , Donner Simon D.
Published: August 2021

Coral reefs are increasingly affected by a combination of acute and chronic disturbances from climate change and local stressors. The coral reefs of the Republic of Kiribati’s Gilbert Islands are exposed to frequent heat stress caused by central-Pacific type El Niño events, and may provide a glimpse into the future of coral reefs in other parts of the world, where the frequency of heat stress events will likely increase due to climate change. Reefs in the Gilbert Islands experienced a series of acute disturbances over the past fifteen years, including mass coral bleaching in 2004–2005 and 2009–2010, and an outbreak of the corallivorous sea starAcanthastercfsolaris, or Crown-of-Thorns (CoTs), in 2014. The local chronic pressures including nutrient loading, sedimentation and fishing vary within the island chain, with highest pressures on the reefs in urbanized South Tarawa Atoll. In this study, we examine how recovery from acute disturbances differs across a gradient of human influence in neighboring Tarawa and Abaiang Atolls from 2012 through 2018. Benthic cover and size frequency data suggests that local coral communities have adjusted to the heat stress via shifts in the community composition to more temperature-tolerant taxa and individuals. In densely populated South Tarawa, we document a phase shift to the weedy and less bleaching-sensitive coralPorites rus, which accounted for 81% of all coral cover by 2018. By contrast, in less populated Abaiang, coral communities remained comparatively more diverse (with higher percentages ofPocilloporaand the octocoralHeliopora)after the disturbances, but reefs had lower overall hard coral cover (18%) and were dominated by turf algae (41%). The CoTs outbreak caused a decline in the cover and mean size of massivePorites, the only taxa that was a ‘winner’ of the coral bleaching events in Abaiang. Although there are signs of recovery, the long-term trajectory of the benthic communities in Abaiang is not yet clear. We suggest three scenarios: they may remain in their current state (dominated by turf algae), undergo a phase shift to dominance by the macroalgaeHalimeda, or recover to dominance by thermally tolerant hard coral genera. These findings provide a rare glimpse at the future of coral reefs around the world and the ways they may be affected by climate change, which may allow scientists to better predict how other reefs will respond to increasing heat stress events across gradients of local human disturbance.
Trusting the experts: The domain-specificity of prestige-biased social learning
Authors: Brand Charlotte O. , Mesoudi Alex , Morgan Thomas J. H.
Published: August 2021

Prestige-biased social learning (henceforth “prestige-bias”) occurs when individuals predominantly choose to learn from a prestigious member of their group, i.e. someone who has gained attention, respect and admiration for their success in some domain. Prestige-bias is proposed as an adaptive social-learning strategy as it provides a short-cut to identifying successful group members, without having to assess each person’s success individually. Previous work has documented prestige-bias and verified that it is used adaptively. However, the domain-specificity and generality of prestige-bias has not yet been explicitly addressed experimentally. By domain-specific prestige-bias we mean that individuals choose to learn from a prestigious model only within the domain of expertise in which the model acquired their prestige. By domain-general prestige-bias we mean that individuals choose to learn from prestigious models in general, regardless of the domain in which their prestige was earned. To distinguish between domain specific and domain general prestige we ran an online experiment (n = 397) in which participants could copy each other to score points on a general-knowledge quiz with varying topics (domains). Prestige in our task was an emergent property of participants’ copying behaviour. We found participants overwhelmingly preferred domain-specific (same topic) prestige cues to domain-general (across topic) prestige cues. However, when only domain-general or cross-domain (different topic) cues were available, participants overwhelmingly favoured domain-general cues. Finally, when given the choice between cross-domain prestige cues and randomly generated Player IDs, participants favoured cross-domain prestige cues. These results suggest participants were sensitive to the source of prestige, and that they preferred domain-specific cues even though these cues were based on fewer samples (being calculated from one topic) than the domain-general cues (being calculated from all topics). We suggest that the extent to which people employ a domain-specific or domain-general prestige-bias may depend on their experience and understanding of the relationships between domains.
Detection of retinal changes with optical coherence tomography angiography in mild cognitive impairment and Alzheimer’s disease patients: A meta-analysis
Authors: Hui Jingwen , Zhao Yun , Yu Shasha , Liu Jinfeng , Chiu Kin , Wang Yan
Published: August 2021

Objective

To assess retinal microvascular network impairments in the eyes of mild cognitive impairment (MCI) and Alzheimer’s disease (AD) patients with optical coherence tomography angiography (OCTA).

Design

Systematic review and meta-analysis.

Methods

A literature search was conducted in the PubMed and EMBASE databases to identify relevant studies detecting retinal microvascular attenuation among AD, MCI patients and cognitively healthy controls (HCs) by OCTA. Data were extracted by Review Manager V.5.4 and Stata V.14.0.

Results

Eight investigations were included in this meta-analysis, with 150 AD patients, 195 MCI patients and 226 HCs were eligible for meta-analysis. Evidence based on these studies demonstrated that there was a significantly decreased vessel density (VD) of the Optovue group in superficial capillary plexus (SCP): WMD = -2.26, 95% CI: -3.98 to -0.55, p = 0.01; in deep capillary plexus (DCP): WMD = -3.40, 95% CI: -5.99 to -0.81, p = 0.01, VD of the Zeiss group in SCP:WMD = -0.91, 95% CI: -1.79 to -0.02, p = 0.05 and an enlarged fovea avascular zone (FAZ):WMD = 0.06, 95% CI: 0.01 to 0.11, P = 0.02 in OCTA measurements of MCI patients. Additionally, in OCTA measurements of AD patients, there was a significantly decreased VD in the SCP: WMD = -1.88, 95% CI: -2.7 to -1.07, p<0.00001. In contrast, there was no significant decrease in DCP nor enlargement of FAZ in AD patients.

Conclusion

Retinal microvascular alternations could be optimally screened in MCI patients detected by OCTA, which could be a warning sign of relative changes in the MCI before progressing to AD. Retinal microvasculature changes worth further investigation in larger scale clinical trials.
Queen honey bees exhibit variable resilience to temperature stress
Authors: McAfee Alison , Tarpy David R. , Foster Leonard J.
Published: August 2021

Extreme temperature exposure can reduce stored sperm viability within queen honey bees; however, little is known about how thermal stress may directly impact queen performance or other maternal quality metrics. Here, in a blind field trial, we recorded laying pattern, queen mass, and average callow worker mass before and after exposing queens to a cold temperature (4°C, 2 h), hot temperature (42°C, 2 h), and hive temperature (33°C, control). We measured sperm viability at experiment termination, and investigated potential vertical effects of maternal temperature stress on embryos using proteomics. We found that cold stress, but not heat stress, reduced stored sperm viability; however, we found no significant effect of temperature stress on any other recorded metrics (queen mass, average callow worker mass, laying patterns, the egg proteome, and queen spermathecal fluid proteome). Previously determined candidate heat and cold stress biomarkers were not differentially expressed in stressed queens, indicating that these markers only have short-term post-stress diagnostic utility. Combined with variable sperm viability responses to temperature stress reported in different studies, these data also suggest that there is substantial variation in temperature tolerance, with respect to impacts on fertility, amongst queens. Future research should aim to quantify the variation and heritability of temperature tolerance, particularly heat, in different populations of queens in an effort to promote queen resilience.
Using symptom-based case predictions to identify host genetic factors that contribute to COVID-19 susceptibility
Authors: van Blokland Irene V. , Lanting Pauline , Ori Anil P. S. , Vonk Judith M. , Warmerdam Robert C. A. , Herkert Johanna C. , Boulogne Floranne , Claringbould Annique , Lopera-Maya Esteban A. , Bartels Meike , Hottenga Jouke-Jan , Ganna Andrea , Karjalainen Juha ,   Lifelines COVID-19 cohort study,   The COVID-19 Host Genetics Initiative, Hayward Caroline , Fawns-Ritchie Chloe , Campbell Archie , Porteous David , Cirulli Elizabeth T. , Schiabor Barrett Kelly M. , Riffle Stephen , Bolze Alexandre , White Simon , Tanudjaja Francisco , Wang Xueqing , Ramirez Jimmy M. , Lim Yan Wei , Lu James T. , Washington Nicole L. , de Geus Eco J. C. , Deelen Patrick , Boezen H. Marike , Franke Lude H.
Published: August 2021

Epidemiological and genetic studies on COVID-19 are currently hindered by inconsistent and limited testing policies to confirm SARS-CoV-2 infection. Recently, it was shown that it is possible to predict COVID-19 cases using cross-sectional self-reported disease-related symptoms. Here, we demonstrate that this COVID-19 prediction model has reasonable and consistent performance across multiple independent cohorts and that our attempt to improve upon this model did not result in improved predictions. Using the existing COVID-19 prediction model, we then conducted a GWAS on the predicted phenotype using a total of 1,865 predicted cases and 29,174 controls. While we did not find any common, large-effect variants that reached genome-wide significance, we do observe suggestive genetic associations at two SNPs (rs11844522, p = 1.9x10-7; rs5798227, p = 2.2x10-7). Explorative analyses furthermore suggest that genetic variants associated with other viral infectious diseases do not overlap with COVID-19 susceptibility and that severity of COVID-19 may have a different genetic architecture compared to COVID-19 susceptibility. This study represents a first effort that uses a symptom-based predicted phenotype as a proxy for COVID-19 in our pursuit of understanding the genetic susceptibility of the disease. We conclude that the inclusion of symptom-based predicted cases could be a useful strategy in a scenario of limited testing, either during the current COVID-19 pandemic or any future viral outbreak.
Form, function, and divergence of a generic fin shape in small cetaceans
Authors: Pavlov Vadim , Vincent Cecile , Mikkelsen Bjarni , Lebeau Justine , Ridoux Vincent , Siebert Ursula
Published: August 2021

Tail flukes as well as the dorsal fin are the apomorphic traits of cetaceans which appeared during the evolutionary process of adaptation to the aquatic life. Both appendages present a wing-like shape associated with lift generation and low drag. We hypothesized that the evolution of fins as lifting structures led to a generic wing design, where the dimensionless parameters of the fin cross-sections are invariant with respect to the body length and taxonomy of small cetaceans (Hypothesis I). We also hypothesized that constraints on variability of a generic fin shape are associated with the primary function of the fin as a fixed or flapping hydrofoil (Hypothesis II). To verify these hypotheses, we examined how the variation in the fin’s morphological traits is linked to the primary function, species and body length. Hydrodynamic characteristics of the fin cross-sections were examined with the CFD software and compared with similar engineered airfoils. Generic wing design of both fins was found in a wing-like planform and a streamlined cross-sectional geometry optimized for lift generation. Divergence in a generic fin shape both on the planform and cross-sectional level was found to be related with the fin specialization in fixed or flapping hydrofoil function. Cross-sections of the dorsal fin were found to be optimized for the narrow range of small angles of attack. Cross-sections of tail flukes were found to be more stable for higher angles of attack and had gradual stall characteristics. The obtained results provide an insight into the divergent evolutionary pathways of a generic wing-like shape of the fins of cetaceans under specific demands of thrust production, swimming stability and turning control.
Single or combined ablation of peripheral serotonin and p21 limit adipose tissue expansion and metabolic alterations in early adulthood in mice fed a normocaloric diet
Authors: Saponara Enrica , Chen Rong , Reding Theresia , Zuellig Richard , Henstridge Darren C. , Graf Rolf , Sonda Sabrina
Published: August 2021

Identifying the fundamental molecular factors that drive weight gain even in the absence of hypercaloric food intake, is crucial to enable development of novel treatments for the global pandemic of obesity. Here we investigated both adipose tissue-specific and systemic events that underlie the physiological weight gain occurring during early adulthood in mice fed a normocaloric diet. In addition, we used three different genetic models to identify molecular factors that promote physiological weight gain during normocaloric and hypercaloric diets. We demonstrated that normal physiological weight gain was accompanied by an increase in adipose tissue mass and the presence of cellular and metabolic signatures typically found during obesity, including adipocyte hypertrophy, macrophage recruitment into visceral fat and perturbed glucose metabolism. At the molecular level, this was associated with an increase in adipose tissue tryptophan hydroxylase 1 (Tph1) transcripts, the key enzyme responsible for the synthesis of peripheral serotonin. Genetic inactivation of Tph1 was sufficient to limit adipose tissue expansion and associated metabolic alterations. Mechanistically, we discovered that Tph1 inactivation resulted in down-regulation of cyclin-dependent kinase inhibitor p21Waf1/Cip1 expression. Single or double ablation of Tph1 and p21 were equally effective in preventing adipocyte expansion and systemic perturbation of glucose metabolism, upon both normocaloric and hypercaloric diets. Our results suggest that serotonin and p21 act as a central molecular determinant of weight gain and associated metabolic alterations, and highlights the potential of targeting these molecules as a pharmacologic approach to prevent the development of obesity.
Good practices for dialysis education, treatment, and eHealth: A scoping review
Authors: van Eck van der Sluijs Anita , Vonk Sanne , van Jaarsveld Brigit C. , Bonenkamp Anna A. , Abrahams Alferso C.
Published: August 2021

Background

Recommendations regarding dialysis education and treatment are provided in various (inter)national guidelines, which should ensure that these are applied uniformly in nephrology and dialysis centers. However, there is much practice variation which could be explained by good practices: practices developed by local health care professionals, which are not evidence-based. Because an overview of good practices is lacking, we performed a scoping review to identify and summarize the available good practices for dialysis education, treatment, and eHealth.

Methods

Embase, Pubmed, the Cochrane Library, CINAHL databases and Web of Science were searched for relevant articles using all synonyms for the words ‘kidney failure’, ‘dialysis’, and ‘good practice’. Relevant articles were structured according to the categories dialysis education, dialysis treatment or eHealth, and assessed for content and results.

Results

Nineteen articles (12 for dialysis education, 3 for dialysis treatment, 4 for eHealth) are identified. The good practices for education endorse the importance of providing complete and objective predialysis education, assisting peritoneal dialysis (PD) patients in adequately performing PD, educating hemodialysis (HD) patients on self-management, and talking with dialysis patients about their prognosis. The good practices for dialysis treatment focus mainly on dialysis access devices and general quality improvement of dialysis care. Finally, eHealth is useful for HD and PD and affects both quality of care and health-related quality of life.

Conclusion

Our scoping review identifies 19 articles describing good practices and their results for dialysis education, dialysis treatment, and eHealth. These good practices could be valuable in addition to guidelines for increasing shared-decision making in predialysis education, using patients’ contribution in the implementation of their dialysis treatment, and advanced care planning.
Evaluating the effect of a community score card among pregnant and breastfeeding women living with HIV in two districts in Malawi
Authors: Kays Megan , Woelk Godfrey , Callahan Tegan , Katirayi Leila , Montandon Michele , Chauwa Felluna , Laterra Anne , Sampathkumar Veena , Kayira Dumbani , Kalua Thokozani , Kazemi Erin , Hoffman Heather , Modi Surbhi
Published: August 2021

Malawi faces challenges with retaining women in prevention of mother-to-child HIV transmission (PMTCT) services. We evaluated Cooperative for Assistance and Relief Everywhere, Inc. (CARE’s) community score card (CSC) in 11 purposively selected health facilities, assessing the effect on: (1) retention in PMTCT services, (2) uptake of early infant diagnosis (EID), (3) collective efficacy among clients, and (4) self-efficacy among health care workers (HCWs) in delivering quality services. The CSC is a participatory community approach. In this study, HCWs and PMTCT clients identified issues impacting PMTCT service quality and uptake and implemented actions for improvement. A mixed-methods, pre- and post-intervention design was used to evaluate the intervention. We abstracted routine clinical data on retention in PMTCT services for HIV-positive clients attending their first antenatal care visit and EID uptake for their infants for 8-month periods before and after implementation. To assess collective efficacy and self-efficacy, we administered questionnaires and conducted focus group discussions (FGDs) pre- and post-intervention with PMTCT clients recruited from CSC participants, and HCWs providing HIV care from facilities. Retention of HIV-positive women in PMTCT services at three and six months and EID uptake was not significantly different pre- and post-implementation. For the clients, the collective efficacy scale average improved significantly post-intervention, (p = 0.003). HCW self-efficacy scale average did not improve. Results from the FGDs highlighted a strengthened relationship between HCWs and PMTCT clients, with clients reporting increased satisfaction with services. However, the data indicated continued challenges with stigma and fear of disclosure. While CSC may foster mutual trust and respect between HCWs and PMTCT clients, we did not find it improved PMTCT retention or EID uptake within the short duration of the study period. More research is needed on ways to improve service quality and decrease stigmatized behaviors, such as HIV testing and treatment services, as well as the longer-term impacts of interventions like the CSC on clinical outcomes.
Alcohol use and cardiometabolic risk in the UK Biobank: A Mendelian randomization study
Authors: Lankester Joanna , Zanetti Daniela , Ingelsson Erik , Assimes Themistocles L.
Published: August 2021

Observational studies suggest alcohol use promotes the development of some adverse cardiometabolic traits but protects against others including outcomes related to coronary artery disease. We used Mendelian randomization (MR) to explore causal relationships between the degree of alcohol consumption and several cardiometabolic traits in the UK Biobank. Using the well-establishedADH1BArg47His variant (rs1229984) and up to 24 additional SNPs recently found to be associated with alcohol consumption in an independent dataset as instruments, we conducted two-stage least squares and inverse weighted variance MR analyses, both as one-sample analyses in the UK Biobank and as two-sample analyses in external consortia. In the UK Biobank inverse variance weighted analyses, we found that one additional drink of alcohol per day was positively associated with systolic blood pressure (beta = 2.65 mmHg [1.40, 3.89]), hemorrhagic stroke (OR = 2.25 [1.41, 3.60]), and atrial fibrillation (OR = 1.26 [1.07, 1.48]), which were replicated in multivariable analyses. Alcohol was also associated with all cardiovascular disease and all-cause death. A positive association with myocardial infarction did not replicate in multivariable analysis, with suggestive mediation through blood pressure; similarly, a positive association between alcohol use with type 2 diabetes was mitigated by BMI in multivariable analysis. Findings were generally null in replication with two-sample analyses. Alcohol was not protective for any disease outcome with any analysis method, dataset, or strata. Stratifications by sex and smoking in the UK Biobank revealed higher point estimates of risk for several outcomes for men and mixed results for smoking strata, but no statistically significant heterogeneity. Our results are consistent with an overall harmful and/or null effect of alcohol on cardiometabolic health at all levels of use and suggest that even moderate alcohol use should not be promoted as a part of a healthy diet and lifestyle.
The expression of prosaposin and its receptors, GRP37 and GPR37L1, are increased in the developing dorsal root ganglion
Authors: Taniguchi Miho , Nabeka Hiroaki , Yamamiya Kimiko , Khan Md. Sakirul Islam , Shimokawa Tetsuya , Islam Farzana , Doihara Takuya , Wakisaka Hiroyuki , Kobayashi Naoto , Hamada Fumihiko , Matsuda Seiji
Published: August 2021

Prosaposin (PSAP), a highly conserved glycoprotein, is a precursor of saposins A–D. Accumulating evidence suggests that PSAP is a neurotrophic factor, as well as a regulator of lysosomal enzymes. Recently, the orphan G-protein-coupled receptors GPR37 and GPR37L1 were recognized as PSAP receptors, but their functions have not yet been clarified. In this study, we examined the distribution of PSAP and its receptors in the dorsal root ganglion (DRG) during development using specific antibodies, and showed that PSAP accumulates primarily in lysosomes and is dispersed throughout the cytoplasm of satellite cells. Later, PSAP colocalized with two receptors in satellite cells, and formed a characteristic ring shape approximately 8 weeks after birth, during a period of rapid DRG development. This ring shape, which was only observed around larger neurons, is evidence that several satellite cells are synchronously activated. We found that sortilin, a transporter of a wide variety of intracellular proteins containing PSAP, is strongly localized to the inner side of satellite cells, which contact the neuronal surface. These findings suggest that PSAP and GPR37/GPR37L1 play a role in activating both satellite and nerve cells.
Demographic and socioeconomic inequalities in ideal cardiovascular health: A systematic review and meta-analysis
Authors: Janković Janko , Mandić-Rajčević Stefan , Davidović Maša , Janković Slavenka
Published: August 2021

Background

In 2010, the American Heart Association introduced a new concept of ideal cardiovascular health (CVH) defined as the simultaneous presence of 7 favorable CVH metrics (smoking, diet, physical activity, body mass index, blood pressure, total cholesterol, and fasting blood glucose). The objective of this study was to conduct a systematic literature review and meta-analysis of studies examining the prevalence of ideal CVH, and each of the ideal CVH metrics as well as the relationship between socio-demographic determinants and ideal CVH.

Methods

A comprehensive literature search was conducted in Medline and Scopus databases for studies published between 1 January 2010 and 30 June 2020. A total of 50 studies including 2,148,470 participants were analyzed. Associations were estimated using DerSimonian-Laird random-effect models. Heterogeneity was investigated through subgroup analyses, Q-test, and I2 statistics.

Results

This study showed a low prevalence of ideal CVH defining as 6 and 7 ideal metrics (3.3%). Among seven ideal CVH metrics, smoking was the best metric (71%), while the poorest CVH metric was a healthy diet (5.8%). Gender was a statistically significant moderator of ideal smoking (81% in females and 60% in males) and ideal blood pressure (42% in females and 30% in males). Females and young adults had better CVH status compared to males and older adults. Also, more educated and better-off individuals had a greater number of ideal CVH metrics.

Conclusions

To the best of our knowledge, this is the first systematic review on the relationship between participants’ socioeconomic status and ideal CVH. The results suggest that the prevalence of ideal CVH and most metrics was unsatisfactory. In order to achieve the improvement of the CVH metrics and the overall ideal CVH, nationwide prevention efforts at the population and individual levels are urgently needed.
Evaluation of automated specialty palliative care in the intensive care unit: A retrospective cohort study
Authors: Secunda Katharine E. , Krolikowski Kristyn A. , Savage Madeline F. , Kruser Jacqueline M.
Published: August 2021

Introduction

Automated specialty palliative care consultation (SPC) has been proposed as an intervention to improve patient-centered care in the intensive care unit (ICU). Existing automated SPC trigger criteria are designed to identify patients at highest risk of in-hospital death. We sought to evaluate common mortality-based SPC triggers and determine whether these triggers reflect actual use of SPC consultation. We additionally aimed to characterize the population of patients who receive SPC without meeting mortality-based triggers.

Methods

We conducted a retrospective cohort study of all adult ICU admissions from 2012–2017 at an academic medical center with five subspecialty ICUs to determine the sensitivity and specificity of the five most common SPC triggers for predicting receipt of SPC. Among ICU admissions receiving SPC, we assessed differences in patients who met any SPC trigger compared to those who met none.

Results

Of 48,744 eligible admissions, 1,965 (4.03%) received SPC; 979 (49.82%) of consultations met at least 1 trigger. The sensitivity and specificity for any trigger predicting SPC was 49.82% and 79.61%, respectively. Patients who met no triggers but received SPC were younger (62.71 years vs 66.58 years, mean difference (MD) 3.87 years (95% confidence interval (CI) 2.44–5.30) p<0.001), had longer ICU length of stay (11.43 days vs 8.42 days, MD -3.01 days (95% CI -4.30 –-1.72) p<0.001), and had a lower rate of in-hospital death (48.68% vs 58.12%, p<0.001).

Conclusion

Mortality-based triggers for specialty palliative care poorly reflect actual use of SPC in the ICU. Reliance on such triggers may unintentionally overlook an important population of patients with clinician-identified palliative care needs.
COVID-19 severity: Studying the clinical and demographic risk factors for adverse outcomes
Authors: Shoaib Naila , Noureen Naila , Munir Rimsha , Shah Farhad Ali , Ishtiaq Noshaba , Jamil Nazia , Batool Rida , Khalid Mohammad , Khan Ihsan , Iqbal Naser , Zaidi Nousheen
Published: August 2021

Background

The primary goal of the presented cross-sectional observational study was to determine the clinical and demographic risk factors for adverse coronavirus disease 2019 (COVID-19) outcomes in the Pakistani population.

Methods

We examined the individuals (n = 6331) that consulted two private diagnostic centers in Lahore, Pakistan, for COVID-19 testing between May 1, 2020, and November 30, 2020. The attending nurse collected clinical and demographic information. A confirmed case of COVID-19 was defined as having a positive result through real-time reverse transcriptase polymerase chain reaction (RT-PCR) assay of nasopharyngeal swab specimens.

Results

RT-PCR testing was positive in 1094 cases. Out of which, 5.2% had severe, and 20.8% had mild symptoms. We observed a strong association of COVID-19 severity with the number and type of comorbidities. The severity of the disease intensified as the number of comorbidities increased. The most vulnerable groups for the poor outcome are patients with diabetes and hypertension. Increasing age was also associated with PCR positivity and the severity of the disease.

Conclusions

Most cases of COVID-19 included in this study developed mild symptoms or were asymptomatic. Risk factors for adverse outcomes included older age and the simultaneous presence of comorbidities.
Effectiveness of the school-based oral health promotion programmes from preschool to high school: A systematic review
Authors: Bramantoro Taufan , Santoso Cornelia Melinda Adi , Hariyani Ninuk , Setyowati Dini , Zulfiana Amalia Ayu , Nor Nor Azlida Mohd , Nagy Attila , Pratamawari Dyah Nawang Palupi , Irmalia Wahyuning Ratih
Published: August 2021

Background

Schools offer an opportunity for oral health promotion in children and adolescents. The purpose of this study was to conduct a systematic review of the influence of school-based oral health promotion programmes on oral health knowledge (OHK), behaviours (OHB), attitude (OHA), status (OHS), and quality of life (OHRQoL) of children and adolescents.

Methods

A systematic search on the PubMed and Embase databases was conducted to identify eligible studies. The last search was done on April 24th, 2020. The quality of the included studies was evaluated using the Joanna Briggs Institute (JBI) Critical Appraisal tools.

Results

Of the 997 articles identified, 31 articles were included in this review. Seven studies targeted students in preschools, seventeen in elementary schools, and seven in high schools. Most of these studies revealed positive outcomes. Some studies showed that the school-based oral health promotion programmes showed better OHK, OHB, OHS, and OHRQoL.

Conclusion

Positive results were obtained through oral health promotion programmes in schools, especially those involving children, teachers, and parents.
Immunomodulatory potential of Clinacanthus nutans extracts in the co-culture of triple-negative breast cancer cells, MDA-MB-231, and THP-1 macrophages
Authors: Nordin Fariza Juliana , Pearanpan Lishantini , Chan Kok Meng , Kumolosasi Endang , Yong Yoke Keong , Shaari Khozirah , Rajab Nor Fadilah
Published: August 2021

Triple-negative breast cancer is the main type of breast carcinoma that causes mortality among women because of the limited treatment options and high recurrence. Chronic inflammation has been linked with the tumor microenvironment (TME) in breast cancer progression.Clinacanthus nutans(CN) has gained much attention because of its anticancer properties, but its mechanism remains unclear. We aimed to study the qualitative phytochemical content and elucidate the cytotoxicity effects of CN on human triple-negative breast cancer (TNBC), MDA-MB-231 and human macrophage-like cells such as THP-1 by using sulforhodamine B (SRB) assay. As highly metastatic cells, MDA-MB-231 cells can migrate to the distal position, the effect of CN on migration were also elucidated using the scratch assay. The CN effects on ameliorating chronic inflammation in TME were studied following the co-culture of MDA-MB-231/THP-1 macrophages. The cytokine expression levels of IL-6, IL-1β and tumor necrosis factor-alpha (TNF-α) were determined using ELISA assays. The results showed that both ethanolic and aqueous CN extracts contained alkaloid, phenol and tannin, flavonoid, terpenoid, glycoside and steroid. However, saponin was only found in the aqueous extract of CN. CN was not cytotoxic to both MDA-MB-231 and THP-1 cells. The ability of MDA-MB-231 to migrate was also not halted by CN treatment. However, CN ethanol extract decreased IL-6 at 25 μg/mL (p= 0.02) and 100 μg/mL (p= 0.03) but CN aqueous extract increased IL-6 expression at 50 μg/mL (p= 0.08) and 100 μg/mL (p= 0.02). IL-1β showed decreased expression after treated with CN ethanol and CN aqueous both at 25 μg/mL (p= 0.03). TNF-α were significantly decreased after CN ethanol treatment at concentration 25- (p = 0.001), 50- (p = 0.000) and 100 μg/mL (p= 0.000). CN aqueous extract slightly inhibited TNF-α at all 25–50- and 100 μg/mL (p = 0.001, p = 0.000, p = 0.000, respectively). Overall, CN acts by ameliorating the pro-inflammatory condition in the TME and may be a potential strategy for its anticancer mechanism on highly metastatic breast cancer condition. The major pathways that link both cancer and inflammation were NF-κB and STATs thus further study on the upstream and downstream pathways is needed to fully understand the mechanism of CN extracts in cooling the inflamed TME in breast cancer.
Sexual dysfunction among men with diabetes mellitus attending chronic out-patient department at the three hospitals of Northwest Amhara region, Ethiopia: Prevalence and associated factors
Authors: Getie Mekonnen Eskedar , Yeshita Hedija Yenus , Bishaw Geremew Alehegn
Published: August 2021

Background

Sexual dysfunction is the commonest reproductive health problem observed among men with diabetes mellitus affecting their quality of life. Previous studies conducted in this area were concentrated on the specific domains of sexual dysfunction, and factors were not well-addressed. Therefore, this study was aimed to determine the prevalence of all forms of sexual dysfunction and to identify its associated factors among diabetic men patients attending at the three hospitals of the Amhara region, Ethiopia.

Method

An institutional-based cross-sectional study was conducted involving 462 men diabetic patients at the three hospitals of the northwest Amhara region. A systemic random sampling technique was employed. A face-to-face interviewer-administered change in the sexual functioning questionnaire was used to collect the required data from the 20th of February to the 15th of April 2020. The binary logistic regression was employed and a multivariable logistic regressions model was used to control the effect of confounders. Variables that had an independent correlation with the sexual dysfunction were identified based on a p-value≤ 0.05. Likewise, the direction and strength of association were interpreted using Adjusted Odds Ratio (AOR) with its corresponding 95% CI.

Results

The prevalence of sexual dysfunction was found to be 69.5% (95%CI: (65.1–73.9)). The magnitude of sexual dysfunction was prevalently observed among participants who were older (> 50 years) (AOR = 8.7, 95%CI: (3.3–23.1)). Likewise, the odds of sexual dysfunction was significantly higher among men who have lived with diabetes for a longer duration (AOR = 10.8, 95%CI: (5.3–21.9)), with poor metabolic control (AOR = 3.57, 95%CI: (1.81–7.05)), with comorbid illnesses (AOR = 5.07, 95%CI: (2.16–11.9)), and diabetic-related complications (AOR = 3.01, 95%CI: 1.31–6.92). On the other hand, participants who were physically active (AOR = 0.41, 95%CI: (0.12–0.7)) and satisfied with their relationship (AOR = 0.15, 95%CI: (0.03–0.7)) showed a lesser risk of experiencing sexual dysfunction.

Conclusion

Well over two-thirds of men with diabetes mellitus have experienced sexual dysfunction, implying a public health pressing problem. Older age, lack of physical activity, living longer duration with diabetes, having diabetic complications, experiencing co-morbid illnesses, being unsatisfied with couple relationship, and poor metabolic control increased the risk of developing SD. Therefore, promoting physical exercise, preventing co-morbid illnesses, and couples counseling to build up a good couple relationship are recommended to promote the sexual and reproductive health of men with diabetes.
A model of octopus epidermis pattern mimicry mechanisms using inverse operation of the Turing reaction model
Authors: Ishida Takeshi
Published: August 2021

Many cephalopods such as octopi and squid can purposefully and rapidly change their skin color. Furthermore, it is widely known that some octopi have the ability to rapidly change the color and unevenness of their skin to mimic their surroundings. However, there has been little research published on the mechanisms by which an octopus recognizes its surrounding landscape and changes its skin pattern. We are unaware of any hypothetical model that explains this mimicry mechanism to date. In this study, the mechanism of octopus skin pattern change was assumed to be based on the Turing pattern model. Here, pattern formation using the Turing model was realized using an equivalent filter calculation model and a cellular automaton instead of directly solving the differential equations. It was shown that this model can create various patterns using two feature parameters. Furthermore, for visual recognition where two features are extracted from the Turing pattern image, a method that requires minimal calculation using the characteristics of the cellular Turing pattern model is proposed. These two calculations can be expressed in the same mathematical frame based on the cellular automaton model using a convolution filter. As a result, a model that is capable of extracting features from patterns and reconstructing those patterns rapidly can be created. This represents a basic model of the mimicry mechanism of octopi. Further, this study demonstrates the potential for creating a model with minimal learning calculation for application to machine learning.
Exosomal miR-224 contributes to hemolymph microbiota homeostasis during bacterial infection in crustacean
Authors: Gong Yi , Wei Xiaoyuan , Sun Wanwei , Ren Xin , Chen Jiao , Aweya Jude Juventus , Ma Hongyu , Chan Kok-Gan , Zhang Yueling , Li Shengkang
Published: August 2021

It is well known that exosomes could serve as anti-microbial immune factors in animals. However, despite growing evidences have shown that the homeostasis of the hemolymph microbiota was vital for immune regulation in crustaceans, the relationship between exosomes and hemolymph microbiota homeostasis during pathogenic bacteria infection has not been addressed. Here, we reported that exosomes released from Vibrio parahaemolyticus-infected mud crabs (Scylla paramamosain) could help to maintain the homeostasis of hemolymph microbiota and have a protective effect on the mortality of the host during the infection process. We further confirmed that miR-224 was densely packaged in these exosomes, resulting in the suppression of HSP70 and disruption of the HSP70-TRAF6 complex, then the released TRAF6 further interacted with Ecsit to regulate the production of mitochondrial ROS (mROS) and the expression of Anti-lipopolysaccharide factors (ALFs) in recipient hemocytes, which eventually affected hemolymph microbiota homeostasis in response to the pathogenic bacteria infection in mud crab. To the best of our knowledge, this is the first document that reports the role of exosome in the hemolymph microbiota homeostasis modulation during pathogen infection, which reveals the crosstalk between exosomal miRNAs and innate immune response in crustaceans.
Three monumental murals for Baghdad: Data from Mahmoud Sabri, Shams al-Din Faris, Ahmed al Numan study years in the USSR in context
Authors: Nefedova Olga
Published: August 2021

The first Iraqi undergraduate and postgraduate students to study monumental art came to Moscow in the early 1960s. Mahmoud Sabri (1927–2012) joined the Vasily Surikov Moscow State Academic Art Institute in 1960, Shams al-Din Faris (1937–83) and Ahmed al Numan (1939–2013) joined the Moscow State Stroganov Academy of Industrial and Applied Arts in 1961. In this article, I will address the subject of the graduation mural projects created by these three Iraqi artists within the ideological framework of socialist realism in art and art education in the USSR, and influenced also by their own historical and political environments. My aim is to answer various questions surrounding the historical framework of the murals, such as by whom, when, where and how they were created, why they became a manifestation of the students’ political and social experiences and hopes and why these grand projects were, unfortunately, never realized. Explaining the history of the artworks and artistic practice, I will argue that, as products of the final outcome of knowledge transfer at that time, these artworks are effectively documents of their era, responding to and reflecting their socio-historical contexts both in Iraq and in the USSR.
Characteristics analysis of interior and inset type permanent magnet motors for electric vehicle applications
Authors: Irasari Pudji , Wirtayasa Ketut , Widiyanto Puji , Hikmawan Muhammad Fathul , Kasim Muhammad
Published: August 2021

Permanent magnet motors (PMMs) are widely used in electric vehicles because of their benefits. Based on the permanent magnet topologies on the rotor, PMMs are classified into three types: surface mounted PMM, inset PMM, and interior PMM. This paper discusses a comparison of the characteristics of interior and inset types of PMMs for electric vehicle applications. The study aims to find out the effect of the rotor construction on the magnetic characteristics, torque-speed characteristics, and cogging torque. Simulations were carried out analytically and numerically using the FEMM 4.2 software. The simulation results at the base speed show that the interior PMM generates a higher torque but with a lower rotation, namely 56.47 Nm and 3162 rpm, respectively, while the inset PMM produces higher rotation 4200 rpm but lower output torque of 46.01 Nm. However, with a higher saliency ratio, the interior PMM produces higher maximum torque and speed at both constant torque and field weakening regions than the PMM inset, which is 92.87 Nm and 6310 rpm, consecutively. In terms of cogging torque, the interior PMM raises it slightly higher (2.90 Nm) than the inset PMM (1.93 Nm). The results conclude that, in general, the interior PMM shows better performance in all studied regions and is preferable for electric vehicle applications.
Local positioning system for autonomous vertical take-off and landing using ultra-wide band measurement ranging system
Authors: Tamami Niam , Sumantri Bambang , Kristalina Prima
Published: August 2021

An autonomous vertical take-off and landing (VTOL) must be supported with an accurate positioning system, especially for autonomous take-off, landing, and other tasks in small area. This paper presents a novel method of small local outdoor positioning system for localizing the area of dropping and landing of autonomous VTOL by utilizing the low-cost precision ultra-wide band (UWB) ranging system. We compared symmetrical single sided-two way ranging (SSS-TWR), symmetrical double sided-two way ranging (SDS-TWR), and asymmetrical double sided-two way ranging (ADS-TWR) methods to get precision ranging measurement on UWB radio module. ADS-TWR was superior to others by resulting in minimum distance error. The ADS-TWR average error was 1.38 % (35.88 cm), SDS-TWR average error was 1.83 % (47.58 cm), and SSS-TWR average error was 2.73 % (70.98 cm). Furthermore, the trilateration method was utilized to obtain the local position of the autonomous VTOL. The trilateration method successfully implemented autonomous VTOL quadcopter positioning in a small local outdoor area (20 m x 30 m). Autonomous VTOL has been able to drop seven payloads in seven areas (2 m x 2 m) and landed in the home position (3 m x 3 m) successfully.
Effect of vibration on the efficiency of ultrafiltration
Authors: Szerencsés Szabolcs Gyula , Beszédes Sándor , László Zsuzsanna , Veréb Gábor , Szegedi Balázs , Horváth Zsuzsanna Hovorkáné , Hodúr Cecilia , Rákhely Gábor , Kertész Szabolcs
Published: August 2021

Nowadays, several environmental challenges are present to cope with. One with outstanding importance is the protection of our water supplies, therefore examination of wastewater treatment technology is a priority, especially in the European Union. In this work, the effect of membrane module vibration amplitude on the efficiency of ultrafiltration (UF) was investigated in a vibratory shear enhanced membrane filtration system. Based on the results of model dairy effluent UF and statistical analysis, the maximum vibration level available resulted in the most efficient filtration process, due to the most significant reduction of membrane fouling. From our results it was observed that the permeate fluxes more than doubled, specific energy demand was roughly halved, with almost identical retentions for organic matter, and total filtration resistance was reduced to less than half. Results also showed that setting the optimal operating parameters, an advantageous, efficiency focused, and sustainable wastewater treatment technology can be established.
Generalization of Vaidya’s Metric for A Radiating Star to Rotating Star
Authors:   The Indian Planetary Society (IPS), B-201, Vishnu Apartment, Lokmanya Tilak Road, Borivali (West), Mumbai – 400092 (India), Rawal J.J. , Nikouravan Bijan
Published: August 2021

Schwarzschild's external solution of Einstein’s gravitational field equations in the general theory of relativity for a static star has been generalized by Vaidya [1], taking into account the radiation of the star. Here, we generalize Vaidya’s metric to a star that is rotating and radiating. Although, there is a famous Kerr solution [2] for a rotating star, but here is a simple solution for a rotating star which may be termed as a zero approximate version of the Kerr solution. Results are discussed.