bluuebunny/crossref_metadata_2025 huggingface dataset:
Global Strategic Trends Affecting the Regional Real Estate Market of Russia
Authors: Petrova Polina
Published: November 2023

The article introduces a comprehensive strategic analysis of global trends that affect the development of the regional housing market in Russia. The list of trends included globalization, urbanization, world population growth, expansion of global real estate market, and preventive development of strategic scenarios to counteract the current emergency in the real estate market. Anti-emergency scenarios for regional markets should take into account these global trends. For a regional real estate market, an emergency period is a period of cyclical growth in real estate prices, characterized by excess investment caused by long-term speculative expectations of investors. The study relied on the theory of strategy and the methodology of strategizing developed by Professor V.L. Kvint, Dr.Sc.(Econ.), Foreign Member of the Russian Academy of Sciences. The author used the method of decomposition to divide the emergency period into stages: the time occupied by each stage depended on the abovementioned global trends via supply and demand factors. The demand factor referred to the regional population whereas the supply factor was associated with the construction sector. Therefore, global strategic trends cannot be overlooked by regional strategists who develop plans to counteract the current emergency scenarios.
Prospects of Youth Communication Communities in Strategic Student Communication
Authors: Kalinin Vladimir
Published: November 2023

Student communication communities grant youth perspective to academic, urban, and regional strategizing. They develop a hierarchically organized system of coordinated academic communication strategies across the country and the world. The key strategic goal of youth communication communities is to provide effective strategic communication between students, universities, authorities, and society. They stimulate interdisciplinary research through open discussion and bring together young specialists from different fields of science. In addition, they establish ties between Russian students and foreign student communities, thus initiating intercultural academic cooperation. This research offers a comprehensive solution to various issues of youth communication in an emergency period: a system of youth communication communities to unite young people across cultures in pursuit of the same strategic goals.
Natural habitats for the stable existence of wild boars (Sus scrofa) in the North
Authors: Popov Igor , Starikov Dmitry
Published: November 2023

Wild boar Sus scrofa populations are actively expanding northwards. Their presence in the North is closely tied to anthropogenic activities, as wild boars are either fed, or find food and suitable habitat at farmlands. However, the nature reserves of the northern part of Russia show that wild boars are able to survive on their own even in a completely natural environment. In the taiga zone, there are habitats providing for their survival in winter: wetlands in mires and around large water bodies, and dense spruce forests. Continued northwards expansion of wild boar range is likely if pressure from hunting is reduced. Modelling based on climatic variables also shows that they could potentially inhabit vast areas in the North. The existence of wild boars in the North is interrelated with other species of relatively large mammals (beavers and roe deer) and partly supports the idea of “Pleistocene rewilding” in a boreal environment, i.e., the potential to increase the variety and numbers of megafauna representatives.
Cancer as a potential sequela of COVID-19 — should we modify 3D cell culture models accordingly?
Authors: Petersen Elena , Chudakova Daria , Erdyneeva Daiana , Zorigt Dulamsuren , Shabalina Evgeniya , Karalkin Pavel , Reshetov Igor
Published: November 2023

COVID-19 pandemic was caused by SARS-CoV-2, a novel virus from the family Coronaviridae, firstly identified in Wuhan, China in 2019. COVID-19 remains one of the main challenges of healthcare, given growing numbers of people with COVID-19 in anamnesis, and given the long-lasting consequences and complications of this disease. Cancer is one of the most common diseases in the world, thus a big part of the population is affected by both COVID-19 and cancer. In this succinct review we refer to several recent works expressing a view that COVID-19 might be oncogenic, and describe molecular mechanisms of such phenomena. Next, we describe several tumorigenic changes in the tissue microenvironment as COVID-19 sequelae, which can potentially affect cancer pathogenesis and response of a tumor to therapy. 3D cell culture models are a “golden standard” of in vitro studies in translational oncology. To the best of our knowledge, 3D cell culture systems to study tumor behavior in the tissue microenvironment affected by COVID-19 have not been developed yet. We propose several actionable steps which can be taken to modify existing 3D cell culture models accordingly, to address the needs of translational oncology in the COVID-19 post-pandemic times.
Cultura organizacional y satisfacción laboral en las pymes comerciales de Cajeme, Sonora, México
Authors: López-Carlón Juan Carlos , Ochoa-Jiménez Sergio , Leyva-Osuna Beatriz Alicia
Published: November 2023

Las pequeñas y medianas empresas (PYMES) poseen gran relevancia en el sector económico mexicano y a la vez se enfrentan a situaciones poco favorables que generan riesgos de pérdidas económicas y de mano de obra calificada, en ese sentido, es importante el estudio de los componentes que intervienen en el funcionamiento de las empresas, como son la cultura organizacional (CO) y la satisfacción laboral (SL), por lo que en este estudio se plantea como objetivo determinar la relación entre ambas variables. Se realizó un estudio con diseño no experimental y de corte transversal, de tipo cuantitativo y correlacional. Se integró un instrumento, el cual fue aplicado a 395 empleados de 79 empresas comerciales. Para el análisis de la información se elaboró un modelo de ecuaciones estructurales en IBM AMOS. Se obtuvo un coeficiente path de 0.82, que permite afirmar que existe una relación positiva y significativa entre la CO y la SL con un alto nivel de relación entre ellas. Así mismo, se determinó un coeficiente de determinación de 0.68, que explica en un alto porcentaje a la SL, lo cual coincide con estudios anteriores, concluyendo que se reafirma dicha relación, además que existen otras variables que complementan su explicación.
Educação para a democracia
Authors: Matielo Etel , Artmann Elizabeth
Published: November 2023

Denominamos agir comunicativo-pedagógico a relação entre comunicação e educação, fundamentada em dois importantes postulados epistêmicos, a teoria do agir comunicativo por Jürgen Habermas, e as bases pedagógicas de Paulo Freire (com o olhar da educação popular em saúde). Este ensaio tem como objetivo refletir como o agir comunicativo-pedagógico pode contribuir para a reflexão sobre processos de formação na área da saúde, pautada nas categorias convergentes destes dois autores como: comunicação/diálogo, interdisciplinaridade, democracia, trabalho e emancipação. O agir pedagógico fundamenta-se nas aprendizagens sociais apoiadas na racionalidade comunicativa, de forma a viabilizar uma cultura dialógica, solidária e radicalmente aberta aos processos de transformação pautados na emancipação social. No agir comunicativo, que articula todos os tipos de ação (Teleológica, Estratégica, Normativa e Comunicativa), os falantes vivenciam experiências que oportunizam consensos e entendimentos. Se estabelece uma relação interna entre práxis e racionalidade, elevando o conteúdo normativo da ação orientada para o entendimento recíproco. Habermas e Freire desenvolvem propostas de ações comunicativas que são profundamente interligadas, motivo pelo qual relaciona-se o papel da comunicação nas relações humanas e consequentemente na saúde. A integração do agir comunicativo com elementos da educação popular potencializa a ação pedagógica. Nessa perspectiva, a linguagem passa a assumir as funções de entendimento e coordenação das atividades orientadas por fins dos diferentes sujeitos da ação e o meio da própria socialização. Logo, a linguagem expressa na fala ou gestos constitui-se por resultados da ação social, que pelo compartilhamento torna-se capaz de produzir mudanças e intervenções significativas nos processos formativos em saúde.
interesse sobre fake news pela ciência da informação
Authors: Melo Willian Lima , Prado Marcos Aparecido Rodrigues do , Silva Taynara Cristina da
Published: November 2023

É recente a evocação do termo de “fake news” em comunicações científicas da comunidade acadêmica brasileira inscrita na grande área de Ciências Sociais Aplicadas. Este artigo objetiva identificar a presença do conceito “fake news” em artigos científicos no domínio da grande área das Ciências Sociais Aplicadas por meio de levantamento na Base de Dados em Ciência da Informação. Metodologicamente, a pesquisa é exploratória com abordagem quantitativa e qualitativa, em que a perspectiva cientométrica foi utilizada para representação dos resultados. Apresenta discussões que reforçam o entendimento do papel da comunicação científica para a consolidação de conceitos que visam refletir demandas presentes na sociedade. Considera positivo o aspecto exploratório das discussões para estudos que podem oferecer contribuições no campo dos estudos métricos, da Biblioteconomia e da Ciência da Informação, no intuito de entender a práxis de elaboração conceitual presente em uma comunidade científica circunscrita.
Porphyrinuria in Autism Spectrum Disorder: A Review
Authors: Bjørklund Geir , Semenova Yuliya , El-Ansary Afaf , Al-Ayadhi Laila Youssef
Published: November 2023

:

Numerous studies demonstrated that the number of children with autism spectrum disorder (ASD) has increased remarkably in the past decade. A portion of ASD etiology, however, is attributed to environmental issues and genetic disorders. We highlighted a scoping review to principally evaluate the current information on mercury exposure in ASD children and to reveal knowledge gaps. Elevated porphyrins concentration in the urinary system related to mercury exposure, such as precoproporphyrin (prcP), coproporphyrin (cP), and pentacarboxyporphyrin (5cxP), was shown in comparison with controls. Moreover, high levels of urinary porphyrins have been elevated in response to heavy metal exposure. The related pattern (increased prcP, cP, and 5cxP) with Hg exposure may be used as biomarkers in the characteristics of ASD symptoms. However, this review highlighted the data gaps because the control groups were not genderand age-matched for ASD children.
Combining Mendelian Randomization Analysis and 3D-QSAR to
Investigate the Effectiveness of a New Series of Hydroxyquinolines in
Osteoarthritis
Authors: Lian Zheng , Su Kunpeng , Lu Hui , Qu Changpeng , Ma Xuexiao
Published: November 2023

Background:

Osteoarthritis (OA) represents a persistent degenerative joint
ailment. As OA advances, profound joint pain coupled with diminished joint function inflicts
substantial physical distress and psychological strain on patients. Presently, pharmacological
solutions for arthritis remain limited, primarily encompassing analgesics
and joint replacement surgical procedures. Hence, non-operative strategies to mitigate
osteoarthritis progression have captured significant attention in orthopedic research.

Objective:

This study aims to discern a definitive causal linkage between ADAMTS-4/5
and osteoarthritis through Mendelian randomization analysis.

:

Moreover, it seeks to anticipate the therapeutic efficacy of a suite of emergent hydroxyquinolines
for osteoarthritis using the Quantitative Structure-Activity Relationship
(QSAR) methodology.

Methods:

Within this study, genetic variants specific to knee osteoarthritis were procured
as exposure variables from a genome-wide association study (GWAS). Genetic
variant data for ADAMTS-4/5 served as the endpoint to evaluate the causal nexus employing
univariate Mendelian randomization. This analysis underpins the hypothesis
that ADAMTS-4/5 presents a promising therapeutic target for osteoarthritis management.
The suppressive properties of novel hydroxyquinolines against ADAMTS-4/5
were subsequently examined through conformational analyses, underscoring the potential
of these compounds as therapeutic candidates for osteoarthritis.

Results:

IVW outcomes from the Mendelian randomization revealed a significant association
of KOA (OR: 1.1675, 95% CI: 1.0003-1.3627, P = 0.0495) with ADAMTS-5.
However, KOA (OR: 1.0801, 95% CI: 0.9256-1.2604, P = 0.3278) displayed no evident
connection with ADAMTS-4. Notably, the instrumental variables manifested neither
heterogeneity nor horizontal pleiotropy. In this research endeavor, 16 pharmacological
models were formulated via the CoMSIA method within 3D conformational relationship
evaluations. A synergistic interplay of hydrophobic, spatial, and hydrogen-bonded receptor
domains emerged as the most predictively potent. The cross-validation coefficient q2
for the optimum model stood at 0.716, with a principal component score of 5, a regression
coefficient r2 of 0.971, a standard estimation error of 0.351, and an f-value of
156.951. Such metrics intimate the commendable predictive prowess of our devised
CoMSIA models.

Conclusion:

The research unearthed a robust causal interrelation between ADAMTS-5
and osteoarthritis via Mendelian randomization. Furthermore, a credible drug model targeting
ADAMTS-5 was constructed. Collectively, these findings illuminate a path forward
in the pursuit of target-specific drugs for osteoarthritis management in subsequent
investigations.
Computational Approaches: A New Frontier in Cancer Research
Authors: Srivastava Shubham , Jain Pushpendra
Published: November 2023

Cancer is a broad category of disease that can start in virtually any organ or tissue of
the body when aberrant cells assault surrounding organs and proliferate uncontrollably. According
to the most recent statistics, cancer will be the cause of 10 million deaths worldwide in 2020,
accounting for one death out of every six worldwide. The typical approach used in anti-cancer
research is highly time-consuming and expensive, and the outcomes are not particularly encouraging.
Computational techniques have been employed in anti-cancer research to advance our
understanding. Recent years have seen a significant and exceptional impact on anticancer research
due to the rapid development of computational tools for novel drug discovery, drug design,
genetic studies, genome characterization, cancer imaging and detection, radiotherapy, cancer
metabolomics, and novel therapeutic approaches. In this paper, we examined the various subfields
of contemporary computational techniques, including molecular docking, artificial intelligence,
bioinformatics, virtual screening, and QSAR, and their applications in the study of cancer.
Identification of Two Novel Pathogenic Variants of the ATM Gene in
the Iranian-Azeri Turkish Ethnic Group by Applying Whole Exome
Sequencing
Authors: Dalal Amandi Amir-Reza , Jabbarpour Neda , Shiva Shadi , Bonyadi Mortaza
Published: November 2023

Background:

The ATM gene encodes a multifunctional kinase involved in important
cellular functions, such as checkpoint signaling and apoptosis, in response to DNA damage. Bi-allelic
pathogenic variants in this gene cause Ataxia Telangiectasia (AT), while carriers of ATM
pathogenic variants are at increased risk of cancer depending on the pathogenicity of the variant
they carry. Identifying pathogenic variants can aid in the management of the disease in carriers.

Methods:

Whole-exome sequencing (WES) was performed on three unrelated patients from the
Iranian-Azeri Turkish ethnic group referred to a genetic center for analysis. WES was also conducted
on 400 individuals from the same ethnic group to determine the frequencies of all ATM
variants. Blood samples were collected from the patients and their family members for DNA extraction,
and PCR-Sanger sequencing was performed to confirm the WES results.

Results:

The first proband with AT disease had two novel compound heterozygote variants
(c.2639-2A>T, c.8708delC) in the ATM gene revealed by WES analysis, which was potentially/-
likely pathogenic. The second proband with bi-lateral breast cancer had a homozygous pathogenic
variant (c.6067G>A) in the ATM gene identified by WES analysis. The third case with a family
history of cancer had a heterozygous synonymous pathogenic variant (c.7788G>A) in the ATM
gene found by WES analysis. Sanger sequencing confirmed the WES results, and bioinformatics
analysis of the mutated ATM RNA and protein structure added evidence for the potential pathogenicity
of the novel variants. WES analysis of the cohort revealed 38 different variants, including
a variant (rs1800057, ATM:c.3161C>G, p.P1054R) associated with prostate cancer that had a higher
frequency in our cohort.

Conclusion:

Genetic analysis of three unrelated families with ATM-related disorders discovered
two novel pathogenic variants. A homozygous missense pathogenic variant was identified in a woman
with bi-lateral breast cancer, and a synonymous but pathogenic variant was found in a family
with a history of different cancers.
Improved Transdermal Delivery of Anti-hypertensive Drug Loaded
Nanostructured Lipid Carriers: Statistical Design, Optimization, Depiction
and Pharmacokinetic Assessment
Authors: Chettupalli Ananda Kumar , Avula Purnachandra Rao , Chauhan Vivek
Published: November 2023

Background:

The vasoselective calcium-channel blocker lercanidipine hydrochloride
(LCH) is poorly absorbed orally (only 10% bioavailability) owing to its low solubility and hepatic
metabolism. Because of the LCH's poor solubility and permeability, bioavailability is low and very
variable, stable aqueous liquid formulations are challenging to create, and a uniform distribution of
the medication is almost impossible to produce.

Objective:

The purpose of this research was to see whether an approach involving the development
of nanostructured lipid carriers (NLCs) might be used to create an effective, innovative oral formulation
of LCH. The efficacy of several synthetic and natural liquid lipids was compared using a hot
homogenization-ultrasonication strategy.

Methods:

Following initial improvements with hot homogenization and ultrasonication, the LCHloaded
NLCs formulation was fine-tuned by Box-Behnken statistical analysis. The optimal LCHNLCs
composition includes the lipid phase (2-4% w/v) of stearic acid and oleic acid, the surfactants
poloxamer 188 (1%) and Tween 80(1%), and other ingredients.

Results:

The optimized NLCs formulation was found to have mean vesicle sizes of 128.72 ± 1.59
nm, polydispersity indices of 0.169 ± 0.06, zeta potentials of -36.81 ± 0.42 mV, and entrapment efficiencies
of 79.84 ± 0.11%. The optimized NLCs formulation released much more LCH (88.74 ± 4.62)
than the LCH-suspension (36.84 ± 0.37%) in in-vitro drug release experiments lasting up to 24 hours.
Ex vivo studies on the ability of LCH-NLCs to pass through the gut showed that drug permeation was
much better than it was with plain LCH-solution. The in vivo pharmacodynamic analysis demonstrated
that, compared to conventional LCH-suspension, NLCs released LCH more slowly and steadily
over a longer time period.

Conclusion:

These findings provide additional evidence that NLCs have great promise as a drug
delivery technology for the treatment of hypertension, just as they show promise as a controlled release
formulation for the treatment of LCH.
Association of Cardiovascular Events with COVID-19 Vaccines Using
Vaccine Adverse Event Reporting System (VAERS): A Retrospective
Study
Authors: Amir Mohd , Latha S. , Sharma Ruchika , Kumar Anoop
Published: November 2023

Background::

COVID-19 vaccines have played a crucial role in reducing the burden of
the global pandemic. However, recent case reports have indicated the association of the COVID-
19 vaccines with cardiovascular events but the exact association is unclear so far.

Objective::

Therefore, the objective of the current study is to find out the association of cardiovascular
events with COVID-19 vaccines.

Methods::

The COVID-19 Vaccine Knowledge Base (Cov19VaxKB) tool was used to query the
Vaccine Adverse Event Reporting System (VAERS) database. The proportional reporting ratio
[PRR (≥2)] with associated chi-squared value (>4), and the number of cases > 0.2% of total
reports, was used to assess the association of COVID-19 vaccines with cardiovascular events.

Results::

A total of 33,754 cases of cardiovascular events associated with COVID-19 vaccines
were found in the Cov19VaxKB tool. The cases were observed in different age groups (18-64,
and 65 years and above) and gender. The disproportionality measures indicate a statistically
significant association between cardiovascular events and COVID-19 vaccines.

Conclusion::

The current study identified a signal of various cardiovascular events with the
COVID-19 vaccines. However, further causality assessment is required to confirm the association.
Regulation of ROS/inflammasome Axis is Essential for Cardiac Regeneration in Aging Rats Receiving Transplantation of Mesenchymal Stem Cells
Authors: Hu Wei-Syun , Chen Jing-Yi , Liao Wei-Yu , Chang Chin-Hsien , Chen Tung-Sheng
Published: November 2023

Background:

Aging is a biological and gradual deterioration of function in living organisms.
Aging is one of the risk factors for heart disease.

Objective:

Although mesenchymal stem cell transplantation shows potential in heart disease treatment,
the relationship between stem cell-based therapy and oxidative stress/inflammasome axis
regulation remains unclear. This study hypothesized that intervention of stem cells showed protective
effect on heart aging induced by D-galactose through regulation of oxidative stress/inflammasome
axis.

Methods:

An aging animal model was designed to test the above hypothesis. Experimental animals
were divided into three groups, including Sham, D-gal (aging rats induced by d-galactose),
and D-gal+WJSC (aging rats receiving mesenchymal stem cells).

Results:

Compared to the Sham, the experimental results indicate that structural alteration (HE
stain and Masson’s Trichrome stain), oxidative stress elevation (increase of TBARS level, expression
of gp-91 and suppression of Sirt-1 as well as SOD2), increase of aging marker p53, suppression
of cardiogenesis marker Troponin T, and inflammasome related protein markers expression
(NLRP3, caspase-1 and IL-1 beta) were significantly observed in D-gal. In contrast, all pathological
pathways were significantly improved in D-gal+WJSC when compared to D-gal. In addition,
migration of stem cells to aging heart tissues was observed in the D-gal+WJSC group.

Conclusion:

These findings suggest that mesenchymal stem cell transplantation effectively ameliorates
aging hearts through oxidative stress/inflammasome axis regulation. The results from this
study provide clinical potential for stem cell-based therapy in the treatment of aging hearts.
Study Deciphering the Crucial Involvement of Notch Signaling Pathway in
Human Cancers
Authors: Pandey Pratibha , Khan Fahad , Singh Megha , verma Aditi , Kumar Hariom , Mazumder Avijit , Rakhra Gurmeen
Published: November 2023

:

In recent years, dysregulation of the notch pathway has been associated with the development
and progression of various cancers. Notch signaling is involved in several cellular
processes, such as proliferation, differentiation, apoptosis, and angiogenesis, and its abnormal
activation can lead to uncontrolled cell growth and tumorigenesis. In various human cancers, the
Notch pathway has been shown to have both tumor-promoting and tumor-suppressive effects,
depending on the context and stage of cancer development. Notch signaling has been implicated
in tumor initiation, cancer cell proliferation, cell migration and maintenance of cancer stem cells
in several human cancers, including leukemia, breast, pancreatic and lung cancer. Understanding
the role of the Notch pathway in cancer development and progression may provide new opportunities
for the development of potent targeted therapies for cancer treatment. Several drugs
targeting the Notch pathway are currently in preclinical or clinical development and may hold
promise for anticancer therapy in the future.
Microwave-Assisted Synthesis of Biologically Relevant Six-Membered N-Heterocycles
Authors: Kamboj Monika , Bajpai Sangeeta , Pandey Garima , Yadav Monika , Banik Bimal K.
Published: November 2023

One of the most efficient non-conventional heating methods is microwave irradiation. In organic synthesis, microwave irradiation has become a popular heating technique as it enhances product yields and purities, reduces reaction time from hours to minutes, and decreases unwanted side reactions. Microwave-assisted organic synthesis utilizes dielectric volumetric heating as an alternative activation method, which results in rapid and more selective transformations because of the uniform heat distribution. Heterocyclic compounds have a profound role in the drug discov-ery and development process along with their applications as agrochemicals, fungicides, herbi-cides, etc., making them the most prevalent form of biologically relevant molecules. Hence, enor-mous efforts have been made to flourish green routes for their high-yielding synthesis under mi-crowave irradiation as a sustainable tool. Among the different clinical applications, heterocyclic compounds have received considerable attention as anti-cancer agents. Heterocyclic moieties have always been core parts of the development of anti-cancer drugs, including market-selling drugs, i.e., 5-fluorouracil, doxorubicin, methotrexate, daunorubicin, etc., and natural alkaloids, such as vinblastine and vincristine. In this review, we focus on the developments in the microwave-assisted synthesis of heterocycles and the anti-cancer activities of particular heterocycles.
Tofacitinib Citrate-loaded Nanoparticle Gel for the Treatment of Alopecia
Areata: Response Surface Design, Formulation and In vitro-in Vivo
Characterization
Authors: Kuchukuntla Mounika , Palanivel Venkatesan , Madhubabu Ananthula
Published: November 2023

Objective:

The purpose of this research was to optimize the design and construction of
nanoparticle gel (TFN-NPs) loaded with tofacitinib citrate (TFN) using poly lactic co glycolic acid
(PLGA).

Method:

PLGA (A) as the polymer, polyvinyl alcohol (PVA) (B) as the stabilizer and stirring speed
(C) as independent variables were used. TFN-NPs were prepared using single emulsion-solvent
evaporation. Box Behnken Design (BBD) was used to determine the optimal component ratio of
TFN-NPs based on point prediction.

Results:

The entrapment efficiency, particle size, and cumulative drug release of the best-composed
TFN-NPs were, respectively, 79.82±0.9%, 236.19±5.07 nm, and 82.31±1.23%; the PDI, zeta potential,
and drug loading were, respectively, 0.297±0.21, -30.21±0.94mV, and 69.81±0.16%. Gel formulation
employing Carbopol as a gelling polymer was then developed using the optimal TFN-NPs
mixture. Gel characterization, drug release, permeation studies, irritation, and pharmacokinetic
studies were also conducted. Further solid state and morphology were evaluated using FTIR, DSC,
XRD, SEM, TEM, and AFM on the developed topical gel formulation (TFN-NPG) and TFN-NPs.
The release and permeation investigations indicated that TFN was slowly released (38.42±2.87%)
and had significantly enhanced penetration into the epidermal membrane of mice. The cumulative
irritation score of 0.33 determined during testing suggested little discomfort. The generated nanogels
are stable and have a high drug penetration profile over the skin, as shown by the findings.
When compared to both pure TFN solutions, TFN-NPs and TFN-NPG demonstrated superior
pharmacokinetic properties.

Conclusion:

Based on the results, the NPs and NPG formulations were depicted to enhance the activity
of TFN compared to the free drug solution. TFN could be a safe and effective treatment for
Alopecia areata. The tofacitinib citrate NPG could be a clinically translatable, safer topical formulation
for managing Alopecia areata.
History Taking
Authors: Ghaly Yousif Nasser , Hadi Najah R. , Alamran Fadhil G.
Published: November 2023

The present chapter is mainly focused on teaching medical students and
junior doctors how to take a history of patients. After taking the history, it's useful to
give the patient a run-down of what they've told you as you understand it. For example:
'Mohammed, from what I understand you've been losing weight, feeling sick, had
trouble swallowing - particularly meat - and the whole thing's been getting you down.
Is that right?' If there is a nod of approval or expressed agreement with the story then
it's fairly certain you're getting what the patient wanted to tell you. If not, then you may
need to try another approach. This technique can avoid incorrect assumptions by the
doctor.
Strange Bedfellows: Anti-trans Feminists, VOX Supporters and Biologicist Academics
Authors: Platero Lucas R.
Published: November 2023

In 2015 and 2016, Professor Esther Mayoko Arjonilla and I wrote two articles that demonstrated the absence of major conflicts between feminist and trans movements in Spain. We explained that since the democratic transition of the 1970s, Spanish feminism had been strongly committed to the sexual and reproductive rights of ‘women’, an inclusive category. This also applied to lesbians, though not without some internal struggles to claim that space (Pineda 2008). We hypothesized that lesbian feminist groups had been the necessary allies for the inclusion of trans women, often based on factors like personal friendship ties, and their leadership in addressing sexual rights (Platero & Arjonilla, 2015). Another key element was the overlap between the two movements in the feminist critique of the pathologization of women, in consonance with critiques of the psychopathologization of trans women.
Creating through COVID-19 - An Art-Based Autoethnographic Account
Authors: Markman Zinemanas Daphna
Published: November 2023

The experience of painting during the COVID-19 period initiated this art-based autoethnographic account. The pandemic affected various fields of life; the discussion is thus pursued from a few interrelated points of view: of an individual coping with the COVID-19 crisis on a personal level, of a painter, of an art therapist, of an art therapy lecturer and supervisor, and an artist involved in community interventions. Artmaking and viewing artworks can enhance communication with the beholder and encourage others to reflect verbally and artistically without words. At times of enforced isolation and loneliness, it is essential to have non-verbal forms of expression available when terms are not always general. At times of global crisis, the implications of making art and aesthetic experiences can be individual, intersubjective, and communal. The unique impact on creators and beholders of art creation during a global crisis is discussed in the author’s artworks. The research is art-based: a combination of autoethnography and art-based research. Emergent experiences showed that artmaking likely helps the creator in times of uncertainty and confusion. It can function as an anchor and a tool for reflecting and working through ongoing crises.
Sosialisasi Edukasi Reproduksi Wanita Berbasis Sains Teknologi Islam melalui e-Modul di Desa Sentul
Authors: Meishanti Ospa Pea Yuanita , Putra Ino Angga , Shobirin Mochammad Syafiuddin , Widianti Arina , Annas Farhani
Published: November 2023

The people of Sentul village, especially women and teenagers, still do not really understand the problems related to women including the solutions, so the service team conducts counseling about the female reproductive system based on Islamic technology to provide knowledge, understanding, concern for and the importance of maintaining the reproductive system in women, also providing education about the development of the reproductive system in women based on Islamic science technology. The implementation method is preparation, namely making products, implementing education in the form of socialization and practice of using e-modules, evaluating implementation by providing an implementation framework and product results in the form of e-modules and analysis of sustainable programs that develop community service implementation programs in Tembelang District. The results of the program evaluation show that the education provided can increase knowledge about the importance of female reproduction, technological developments and Islam. The output product produced by the community service team is an e-module for the female reproductive system based on Islamic science and technology which can be accessed anywhere.

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Ibu-ibu dan remaja Desa Sentul, Kecamatan Tambelang belum memahami problematika yang terkait dengan kewanitaan dan solusinya sehingga tim pengabdian kepada masyarakat melakukan edukasi tentang sistem reproduksi wanita berbasis sains teknologi Islam untuk memberikan pengetahuan, pemahaman, kepedulian dan pentingnya menjaga sistem reproduksi pada wanita, serta memberikan edukasi perkembangan sistem reproduksi kepada wanita. Tahapan pelaksanaan melalui metode persiapan, pelaksanaan, dan hasil, yakni (1) tahap persiapan: penyusunan produk; (2) pelaksanaan berupa sosialisasi edukasi praktik penggunaan; (3) tahap hasil berupa evaluasi pelaksanaan dengan memberikan angket pelaksanaan maupun hasil produk berupa e-modul dan analisis berkelanjutan program yang merupakan pengembangan program pelaksanaan pengabdian di Desa Sentul, Kecamatan Tembelang. Hasil evaluasi program menunjukkan bahwa dengan adanya edukasi yang diberikan dapat meningkatkan pengetahuan akan pentingnya reproduksi wanita, perkembangan teknologi, dan segi keagamaan. Luaran produk yang dihasilkan tim pengabdian masyarakat ini berupa e-modul sistem sistem reproduksi wanita berbasis sains teknologi Islam yang dapat diakses di mana saja.
Indigenous literacy of local knowledge about the signs of natural disaster A case of Way Ela Natural Dam - Maluku
Authors: Rizal Edwin , Nurislaminingsih Rizki
Published: November 2023

Introduction. Various natural disasters occurred in Maluku, with one of the impacts is changing the land surface. One example is  a forest has changed into a hill or a river has changed into a natural dam. In Maluku,  Way Ela natural dam was formed as a resultof the disaster in 2012 and was destroyed again by the disaster in 2013. This natural event that occurred in a relatively short period of time is still remembered by the community. This study aims to explore the types of local knowledge about dam disasters based on their memories.  

Data Collection Method. Data collection in this study was conducted by the interviews.

Data Analysis. Data were analyzed by grouping the themes on natural signs of the formation and  of the broken of the dam. 

Results and Discussion. The formation of dams begins with earthquakes, landslides, dry rivers, and strange animal behavior. Natural signs before a broken-down dam are earthquakes, heavy rain, cracked ground, strange behavior of animals, and changes in cooler air temperature.

Conclusion. This study concludes that the community is aware of three types of disaster signs  including the formation of a dam, before the dam breaks, and when the dam breaks.
Sistem Pemantauan Suhu dan Intensitas Cahaya pada Ruang Kerja (Studi Kasus: Ruang Tugas Akhir Institut Teknologi Sumatera)
Authors: Utami Nia Saputri , Baqaruzi Syamsyarief , Robbani M. Imam , Rahmadana Dani , Banurea George Ray
Published: November 2023

Pandemi Covid-19 mengakibatkan banyaknya disrupsi diberbagai sektor seperti pendidikan, perekonomian, kesehatan, teknologi, dan lainnya. Pemerintah Indonesia pun mengeluarkan beberapa kebijakan nasional selama pandemi Covid-19 terjadi antara lain work from home (WFH), social distancing, pembatasan sosial berskala besar (PSBB) dan pemberlakuan pembatasan kegiatan masyarakat (PPKM). Selama PPKM berlangsung, banyak kantor-kantor yang menerapkan sistem kerja bergantian dimana sebagian pekerja melaksanakan WFH dan sebagian lainnya melaksanakan WFO. Institut Teknologi Sumatera pun menerapkan WFH sebagian selama PPKM. Selama PPKM ini muncul kesadaran mengenai hemat listrik karena sebagian besar perangkat elektronik aktif meskipun jumlah orang di dalam ruangan hanya sedikit. Program studi teknik elektro Institut Teknologi Sumatera memiliki ruangan tugas akhir yang sampai saat ini masih dapat dimanfaatkan oleh mahasiswa untuk mengerjakan tugas akhirnya. Pada ruangan ini terdapat perangkat elektronik seperti lampu dan pendingin ruangan yang berpotensi digunakan secara tidak bijaksana yaitu dengan diaktifkan terus-menerus meskipun tidak ada orang di dalam ruangan tersebut, lupa untuk menonaktifkan perangkat elektronik tersebut ketika meninggalkan ruangan, atau jumlah orang di dalam ruangan hanya sedikit namun perangkat elektronik semuanya aktif sehingga berpotensi terjadinya pemborosan listrik. Maka untuk mengatasi permasalahan tersebut dikembangkan sistem pemantauan suhu dan intensitas cahaya berbasis internet of things agar lampu dan pendingin ruangan digunakan sesuai kebutuhan dan terhindar dari pemborosan listrik. Pada artikel ini, sistem yang dikembangkan dapat memantau suhu, intensitas cahaya, jumlah orang di dalam ruangan serta daya listrik. Lampu dan pendingin ruangan akan aktif sesuai dengan kebutuhan yaitu sesuai dengan jumlah orang yang ada di dalam ruangan tersebut. Sistem ini juga dapat memantau daya konsumsi listrik lampu dan pendingin ruangan. Hardware pada sistem ini menggunakan sensor suhu, sensor cahaya, sensor arus, sensor tegangan, dan mikrokontroler yang dilengkapi dengan modul Wi-Fi. Data hasil pendeteksian sensor-sensor tersebut dikirimkan ke aplikasi Android smartphone melalui koneksi internet agar dapat diakses oleh pengguna. Hasil pengujian hardware sistem menunjukkan bahwa masing-masing sensor dapat mendeteksi sesuai fungsinya dan data hasil pendeteksian pun dapat dikirim serta ditampilkan pada aplikasi Android smartphone. Maka dari itu, sistem pemantauan yang dikembangkan berhasil memantau kondisi ruangan sehingga dapat menghindari pemborosan listrik.
Politeness Strategies of Requests in the TV Series Grey's Anatomy Season 2
Authors: Kinansha Viannisa Akira , Hanidar Sharifah
Published: November 2023

This study explores the use of politeness strategies of requests in the TV Series Grey’s Anatomy Season 2. The request strategies were classified based on the politeness strategies proposed by Brown and Levinson (1987). The results showed that out of the 274 requests found in the TV series, 132 requests (48.18%) were expressed using the bald on-record strategy, 108 occurrences (39.42%) using the negative politeness strategy, 25 occurrences (9.12%) using the positive politeness strategy, and nine occurrences (3.28%) using the off-record politeness strategy. For power, the characters of Grey’s Anatomy Season 2 tend to speak to their interlocutors depending on the power that they have between them. Meanwhile, as for the social distance, the speakers tend to ignore the differences in power that exist between them. The familiarity between the speakers and interlocutors influences them to use direct strategies despite the differences in power.
Antibacterial Activities of Secondary Metabolites Derived from Streptomyces sp. VITGV38 (MCC4869) against Selected Uropathogens
Authors: Hussain Amjad , Christopher John Godwin
Published: November 2023

Streptomyces sp. VITGV38 (MCC8469) was obtained from the VIT University Microbiology Laboratory where it was isolated from tomato plants. This strain was mass-cultured for 15 days and its extracellular metabolites were extracted in ethyl acetate using a liquid–liquid extraction method. The antibacterial test was performed on the ethyl acetate crude extract against selected urinary tract pathogens, Proteus mirabilis (MTCC-442), Enterococcus faecalis (MTCC-439), Klebsiella pneumoniae (MTCC-109), and Escherichia coli (MTCC-1687), The extract developed a clear inhibition zone that measured between 17–21 mm. The minimum inhibition concentration was observed from a concentration of 25 μg/ml against all selected uropathogens. GC-MS analysis revealed 35 diverse compounds in the ethyl acetate crude extract, which includes 1,2 benzenedicarboxylic acid bis(2methylpropyl) ester, dibutyl phthalate, bis (2-ethylhexyl) phthalate, didodecyl phthalate, octadecanoic acid dodecyl ester, and dodecane. These six compounds are the major antimicrobial compounds present in the ethyl acetate extract. VITGV38 showed greyish aerial mycelium. Scanning electron microscopy revealed elliptical spores with a chain-like smooth orientation.
An In Silico Study: Phytochemical Compounds Screening of Garcinia atroviridis Griff. ex T. Anders as Anti-DENV
Authors: Aini Nur Sofiatul , Ansori Arif Nur Muhammad , Kharisma Viol Dhea , Murtadlo Ahmad Affan Ali , Tamam Muhammad Badrut , Sucipto Teguh Hari , Jakhmola Vikash , Rebezov Maksim , Saklani Taru , Zainul Rahadian
Published: November 2023

Dengue virus (DENV) is still global problem and infecting millions of people a year. This virus belongs to Flavivirus and consists of the structural and non-structural proteins including envelop (E), capsid (C), NS2B/NS3, and NS5. Garcinia atroviridis Griff. ex T. Anders is traditional plant that has broad potential as antioxidant, antibacterial, and anti-cancer activities. However, the anti-DENV potential of this plant is uncertain. The objective of this research is to find out the potential of the phytochemical compounds of G. atroviridis as DENV antiviral drugs targeting E, C, NSB2/NS3, and NS5 proteins using molecular simulation approach. Sample retrieval was obtained from PubChem and RCSB PDB. Drug-likeness analysis has been assessed with Swiss ADME based on the pharmacology and pharmacokinetics aspects. Toxicity prediction was done by pkCSM webserver. PyRx was carried out to screen ligand-protein interaction virtually. Visualization of the best interaction was displayed by BIOVIA Discovery Studio. CABS-flex 2.0 version webserver was performed to predict stability interaction. Atroviridin was determined as the most promising as DENV antiviral to be tested by the wet laboratory approach.
Antimicrobial Activity of Black Soldier Fly, Hermetia illucens (Diptera: Stratiomyidae) Larval Hemolymph against Various Pathogenic Bacteria
Authors: Azmiera Nurul , Al-Talib Hassanain , Sahlan Noraziah , Krasilnikova Anna , Sahudin Shariza , Heo Chong Chin
Published: November 2023

The larvae of the black soldier fly (BSFL), Hermetia illucens (Linnaeus, 1758) (Diptera: Stratiomyidae), can survive in environments contaminated with various bacteria by producing antimicrobial compounds. This study, for the very first time, investigated the potential antibacterial activity of hemolymph extracted from BSFL in Malaysia using diffusion and dilution methods. Prior to extraction, the larvae were infected with either Methicillin-resistant Staphylococcus aureus (MRSA) or Escherichia coli. Then, the hemolymph was collected. Serial dilutions from 200 to 12.5 mg/ml of the hemolymph extracts were screened against ten different bacteria. The results showed inhibition of eight out of ten tested bacteria (i.e., MRSA, Staphylococcus aureus, Streptococcus pyogenes, Bacillus subtilis, Micrococcus luteus, Escherichia coli, Klebsiella pneumoniae and Acinetobacter sp.). We found that immunological-challenge larvae have stronger antimicrobial activity than the control groups. The Minimum Inhibitory Concentrations (MIC) for bacteria against for infected larvae were 12.5 mg/ml for MRSA, S. pyogenes, B. subtilis, M. luteus, E. coli, and K. pneumoniae. As for bactericidal activity, the MBC of E. coli infected larvae was 25mg/ml against S. pyogenes and B. subtilis. In conclusion, BSFL hemolymph has antibacterial activity against a range of bacteria and could be a candidate for novel antimicrobial development.
Enhanced Hazardous Material Management through Advanced Robotic Solutions
Authors: Dandavate Prajakta , Agarwal Mayur , Mathapati Viraj , Maurya Ayush , Zade Mayank , Medage Prathamesh
Published: November 2023

Abstract: This abstract introduces an advanced explosive disposal robot built to handle dangerous tasks traditionally done by bomb disposal experts. It comes with cutting-edge technology, a strong chassis for tough terrains, and a precise mechanical arm for delicate tasks and controlled detonations. The robot includes high-res cameras, thermal sensors, and chemical detectors for real-time feedback. It's designed for remote control, ensuring operator safety and precise movements. Safety, reliability, and ease of use are focal points, validated through rigorous testing. This robot reduces risks, improves efficiency, and finds applications in military, law enforcement, and public safety.
Retail Optimization
Authors: Bhardwaj Lavesh
Published: November 2023

Abstract: In an era characterized by the overwhelming influx of digital information and the pervasive influence of social media platforms like Instagram, the act of exploring local venues such as restaurants, concerts, and travel destinations remains a daunting task for urban dwellers. This article aims to address these challenges by introducing a novel program leveraging augmented reality (AR) and virtual reality (VR) technologies to enrich the experience of local exploration. At its core, this program employs advanced machine learning algorithms to provide tailored recommendations, taking into account diverse parameters such as cuisine preferences, geographical location, and seating preferences. The iterative nature of the system ensures continuous improvement based on user feedback. The interactive fusion of VR and AR offers users an immersive and dynamic experience, enabling them to virtually "immerse" themselves in local attractions before embarking on physical visits. This not only enhances the anticipation of exploration but also aids in informed decision-making. The objectives of this update encompass: Surveying the Challenge: Central to this endeavor is the recognition of the formidable challenge posed by the modern-day struggle to explore one's local environment. This difficulty is amplified by the deluge of messages and information inundating social media platforms, further complicating the decision-making process. Content, Methodology, and Technological Innovation: The project is founded on a multidimensional approach that harnesses the potential of AR/VR technology in synergy with machine learning. By tailoring and enhancing the perceptual experience of city dwellers, we aim to revolutionize local exploration. Statement of Insights and Values: While the abstract is inherently devoid of specific research findings, this article will comprehensively review the strategies deployed to identify challenges and evaluate user acceptance and satisfaction. Our findings will serve as valuable guidance for future research initiatives seeking to refine and expand the realm of urban discovery. In summary, this article seeks to bridge the widening gap between digital information overload and meaningful local exploration. By harnessing cutting- edge technologies and user-centric machine learning, we endeavor to provide individuals with a personalized, immersive, and informed means of rediscovering the treasures hidden within their own cities
Tweeting the economy: Analyzing social media sentiments and macroeconomic indicators
Authors: Fitriani Insi , Amalyah Agus Anna
Published: November 2023

This research aims to examine the correlation between social media sentiment and the Consumer Confidence Index (CCI) as well as Gross Domestic Product (GDP) in Indonesia. Data were collected through web scraping from Twitter (now also known as X) spanning from 2019 to 2022 on a monthly basis. Using Pearson and Kendall’s Tau correlation tests, the study found that the correlation between Twitter sentiment and the CCI is not significant. However, there is a significant correlation between Twitter sentiment from news accounts and GDP The findings indicate that the views and perceptions expressed in social media sentiment, particularly from news accounts on Twitter, could serve as an initial indicator of Indonesia's GDP.