bluuebunny/crossref_metadata_2025 huggingface dataset:
Dynamic Linkages between Japan’s Foreign Exchange and Stock Markets: Response to the Brexit Referendum and the 2016 U.S. Presidential Election
Authors: Sultonov Mirzosaid , Jehan Shahzadah Nayyar
Published: June 2018

In this paper, we analyse the response of Japan’s foreign exchange and stock markets to the outcomes of the Brexit referendum and the U.S. presidential election. We estimate the changes in returns of the daily exchange rates of the yen (JPY), the daily closing price index of the Nikkei and the dynamic conditional correlation (DCC) coefficients between the JPY and the Nikkei caused by both events. The empirical findings showed a significant change in the daily logarithmic returns of exchange rates of the JPY and the closing price index of the Nikkei, as well as their time-varying comovement (DCC) after both events. In general, the impact of the U.S. elections on financial markets and their dynamic correlation was stronger than the impact of the Brexit referendum.
A Primer on Disability Discrimination in Higher Education
Authors: Rothstein Laura
Published: June 2018

This article provides an overview of key issues and a focus on some of the most significant and important recent developments that should be given a high priority by university attorneys and higher education administrators and policymakers. It emphasizes the role that administrators responsible for facilitating or coordinating disability services on campus can play in ensuring that faculty members, staff members, and other administrators have the knowledge and tools to ensure access and also to avoid liability to the institution. Major changes in the Trump administration and Congress may signal changes that could affect disability discrimination issues on campus. These changes include changed regulatory guidance, reduced appropriations (including ripple effects from funding for veterans and vocational rehabilitation), and enforcement approaches. While repeal of the ADA is unlikely, regulatory activities might affect its impact.
Ischemic heart disease: structural changes of the atria in preinfarction and postinfarction stages
Authors: Pangonytė Dalia , Morkūnaitė Kristina , Stalioraitytė Elena , Zaikauskienė Jolanta
Published: June 2018

Objective. The aim of this study was to determine atrial structural remodeling during the development of ischemic heart disease. Material and methods. Quantitative histomorphometric parameters of interstitial collagen network (the percentage volume, perimeter, number of fibers per field and collagen–cardiomyocyte volume ratio) of the atria of 132 autopsied men (mean age 49.7±8.9 years) who had died suddenly (within 6 hours since the onset of terminal heart attack symptoms) due to the first (no postinfarction scars) and repeated (postinfarction scars present) acute “pure” ischemic heart disease were investigated. Results. The main remodeling feature of the wall of the both atria among ischemic heart disease subjects is hypertrophy of cardiomyocytes and hyperplasia of interstitial fibrillar collagen network with the maintenance of the same proportion of contractile myocardium and fibrillar collagen network volume. This proportion in the case of the left atrium persists in both pre- and postinfarction ischemic heart disease groups, while myocardium of the right atrium in preinfarction group subjects is characterized by an excess increase of collagen network as compared to cardiomyocyte hypertrophy, which levels again with that of the control in postinfarction group. Conclusions. At preinfarction stage of ischemic heart disease, remodeling of both atria develops and progresses in the left atrium at postinfarction stage in the relationship with increase of left ventricular dysfunction.
The assessment of clinical evaluation and treatment results of high-energy blunt polytrauma patients
Authors: Pamerneckas Algimantas , Pijadin Andrei , Pilipavičius Giedrius , Tamulaitis Gintaras , Toliušis Vytautas , Macas Andrius , Bilskienė Diana , Blazgys Algirdas
Published: June 2018

The aim of this study was to evaluate the mechanism of high-energy blunt trauma, age and gender of patients, severity of regional and multiple injury, ventilation time, length of stay in intensive care unit and in-hospital stay, in-hospital complications, and treatment outcome. Materials and methods. Data on 159 patients with severe multiple injuries, meeting inclusion criteria, were collected prospectively and evaluated retrospectively. Results. The mean age of multiple trauma patients was 43.9±1.4 years; males were injured 2.5 times more often than females (P<0.001). More than half (66.7%) of patients were 17–64-year-old males. Majority (83%) of all patients were injured in motor vehicle crashes, and 52.2% of these patients were pedestrians. The mean Injury Severity Score was 29.5±0.8, and severe (Abbreviated Injury Scale score of 3 and more) injuries of extremities, head, and chest made up 69.1% of all injuries. The mean ventilation time, mean length of stay in intensive care unit, and mean in-hospital stay were 5.5±0.7, 7.0±0.8, and 23.6±1.6 days, respectively. Acute lung complications were the most common (25.2%). Systemic inflammatory response syndrome developed in 7.5% of patients, and sepsis in 3.8% of patients. More than one-fifth (20.8%) of polytrauma patients died. Conclusions. Working-age male pedestrians (17–64 years old) made up two-thirds of all polytrauma patients. Severe injuries of extremities, head, and chest were present in 69.1% of all cases. Lung complications were the most common.
Cerebral edema and its treatment
Authors: Adukauskienė Dalia , Bivainytė Asta , Radavičiūtė Edita
Published: June 2018

Cerebral edema is a life-threatening condition that develops as a result of an inflammatory reaction. Most frequently, this is the consequence of cerebral trauma, massive cerebral infarction, hemorrhages, abscess, tumor, allergy, sepsis, hypoxia, and other toxic or metabolic factors. At present, the following types of cerebral edema are differentiated: the vasogenic cerebral edema resulting from an increased permeability of the endothelium of cerebral capillaries to albumin and other plasma proteins; the cytotoxic cerebral edema resulting from the exhaustion of the energy potential of cell membranes without damage to the barrier; the hydrostatic cerebral edema resulting from disturbance of the autoregulation of cerebral blood circulation; the osmotic cerebral edema resulting from dilution of blood; and the interstitial cerebral edema resulting from acute hydrocephaly. Some authors also differentiate ischemic cerebral edema. At present, when various traumas and traumatic cerebral injuries are frequent causes of death in young people, treatment strategy for cerebral edema is of utmost importance. Monitoring of the patient’s condition in the intensive care unit is a necessity. It is important to ensure proper positioning of the patient – the head should be tilted at 30o in order to optimize the cerebral perfusion pressure and control of the increase in intracranial pressure. Hyperventilation should be applied. Controlled hypothermia decreases the rate of metabolism in the brain. Slightly positive fluid balance should be maintained using crystalloid or colloid (hypertonic–hyperoncotic) solutions, at the same time maintaining cerebral perfusion pressure exceeding 70 mmHg. The treatment includes administration of antihypertensive medications, nonsteroidal antiinflammatory drugs, and barbiturates. Steroids decrease the permeability of capillaries and the hemato-encephalic barrier, promoting the movement of Na+/K+ ions and water through the main endothelial membrane, and therefore they are used in the treatment of vasogenic cerebral edema as well as edema caused by a cerebral tumor. Glutamate and N-methyl-D-aspartate receptor antagonists improve cerebral microcirculation and metabolism. Trometamol corrects cerebral acidosis. Extended cerebral edema is treated surgically via a bilateral decompressive craniotomy, sometimes including craniotomy of lateral and posterior fossae. The treatment of cerebral edema is complex, and positive results may be expected only if the diagnosis and the provision of assistance are timely.
Diagnostic sensitivity and specificity of laryngoscopic signs of reflux laryngitis
Authors: Pribuišienė Rūta , Uloza Virgilijus , Kupčinskas Limas
Published: June 2018

Objective. To assess the diagnostic sensitivity and specificity of the laryngoscopic signs of reflux laryngitis. Material and methods. Using original quantitative evaluation system, the laryngoscopic signs of 108 patients with reflux laryngitis and 90 healthy people were subjected to comparative analysis in this study. Summing up all evaluations of laryngeal changes, laryngoscopic reflux index was proposed. Results. Mucosal lesions and edema of vocal cords along with mucosal lesions of the interarytenoid notch were found to be most significant for diagnostics of reflux laryngitis. Presence of mucosal lesions of the interarytenoid notch (roughness, hypertrophy, keratosis, granuloma) increases the odds ratio to attribute the patient to the reflux laryngitis patient group 21 times (OR=21.32, 95% CI 4.38–103.93; P<0.001). Mucosal lesions (hypertrophy, keratosis, granuloma) and edema of vocal cords were determined as the most sensitive and rather specific laryngoscopic signs. Roughness and grade II hypertrophy of interarytenoid notch were found to be the most specific (98%) and sensitive (56%) laryngoscopic signs of reflux laryngitis. Abnormal values of laryngoscopic reflux index (higher than 5 points) reflect a diagnostic sensitivity of 96% and specificity of 97% differentiating patients with reflux laryngitis from healthy persons. Conclusions. Mucosal lesions and edema of vocal cords along with mucosal lesions of the interarytenoid notch are found to be the most significant laryngoscopic signs for diagnostics of reflux laryngitis. Laryngoscopic reflux index was found to be the most sensitive and specific diagnostic criterion for reflux laryngitis.
Management of cerebrospinal fluid leak after surgical removal of pituitary adenomas
Authors: Tamašauskas Arimantas , Šinkūnas Kęstutis , Draf Wolfgang , Deltuva Vytenis , Matukevičius Algimantas , Rastenytė Daiva , Vaitkus Saulius
Published: June 2018

Objectives. The aim of the study was to evaluate the frequency and the causes of the intra- and postoperative cerebrospinal fluid (CSF) leaks and to discuss the sella closure methods. Methods. During the period from 1995 to 2005, 313 patients underwent 356 transsphenoidal operations for pituitary adenoma. Microadenoma was found in 80 (22.5%) cases, and in 276 (77.5%) cases, macroadenoma was removed. Two different methods to close the sella were used. The first one consisted packing the sella turcica and sphenoidal sinus with autologous fat and restoring the defect of sella turcica with autologous bone. In more resent practice, the regenerated oxidized cellulose (Surgicel®) and collagen sponge with human fibrin (TachoSil®) were used to cover the sella membrane defect, followed by packing the sella with autologous fat and covering the dural defect with Surgicel® and TachoSil®. Results. Adenoma was totally removed in 198 (55.6%) cases out of 356. Microadenoma was totally removed in 91.3% and macroadenoma in 45.3% of cases, respectively. Postoperative complications were noted in 40 (11.2%) patients. Two (0.6%) patients died after surgery. Intraoperative CSF leakage was observed in 58 (16.3%) cases. Postoperative CSF leakages were observed in 3 cases, when the method of packing the sella with just autologous fat was used, whereas in 29 cases when the sella fat packing was used together with Surgicel® and TachoSil® to cover the sella membrane and dural defects, no postoperative CSF leakages were observed. Conclusions. The technique of covering the sella membrane and dural defects with Surgicel® and TachoSil® in the presence of intraoperative CSF leakage appeared to be the most reliable one, as no postoperative CSF leakage applying this technique has been observed.
An In Vitro Corrosion Study of Open Cell Iron Structures with PEG Coating for Bone Replacement Applications
Authors: Haverová Lucia , Oriňaková Renáta , Oriňak Andrej , Gorejová Radka , Baláž Matej , Vanýsek Petr , Kupková Miriam , Hrubovčáková Monika , Mudroň Pavol , Radoňák Jozef , Orságová Králová Zuzana , Morovská Turoňová Andrea
Published: June 2018

Iron-based substrates with polyethylene glycol coating were prepared as possible materials for biodegradable orthopedic implants. Biodegradable materials that provide mechanical support of the diseased tissue at the time of implanting and then disappear gradually during the healing process are sometimes favored instead of permanent implants. The implant degradation rate should match the time of the tissue regrowth. In this work, the degradation behavior of iron-based foams was studied electrochemically during immersion tests in Hanks’ solution. The corrosion rate of the polyethylene glycol-coated samples increased and the corrosion potential shifted to more negative values. This indicates an enhanced degradation rate as compared to the uncoated material, fulfilling the goal of being able to tune the degradation rate. It is the interfacial interaction between the hydrophilic polymer layer and the iron surface that is responsible for the enhanced oxidation rate of iron.
3D Printed Microfluidic Features Using Dose Control in X, Y, and Z Dimensions
Authors: Beauchamp Michael , Gong Hua , Woolley Adam , Nordin Gregory
Published: June 2018

Interest has grown in recent years to leverage the possibilities offered by three-dimensional (3D) printing, such as rapid iterative changes; the ability to more fully use 3D device volume; and ease of fabrication, especially as it relates to the creation of complex microfluidic devices. A major shortcoming of most commercially available 3D printers is that their resolution is not sufficient to produce features that are truly microfluidic (<100 × 100 μm2). Here, we test a custom 3D printer for making ~30 μm scale positive and negative surface features, as well as positive and negative features within internal voids (i.e., microfluidic channels). We found that optical dosage control is essential for creating the smallest microfluidic features (~30 µm wide for ridges, ~20 µm wide for trenches), and that this resolution was achieved for a number of different exposure approaches. Additionally, we printed various microfluidic particle traps, showed capture of 25 µm diameter polymer beads, and iteratively improved the trap design. The rapid feedback allowed by 3D printing, as well as the ability to carefully control optical exposure conditions, should lead to new innovations in the types and sizes of devices that can be created for microfluidics.
The Effect of Grinding on Tremolite Asbestos and Anthophyllite Asbestos
Authors: Bloise Andrea , Kusiorowski Robert , Gualtieri Alessandro F.
Published: June 2018

The six commercial asbestos minerals (chrysotile, fibrous actinolite, crocidolite, amosite, fibrous tremolite, and fibrous anthophyllite) are classified by the IARC as carcinogenic to humans. There are currently several lines of research dealing with the inertisation of asbestos minerals among which the dry grinding process has received considerable interest. The effects of dry grinding on tremolite asbestos and anthophyllite asbestos in eccentric vibration mills have not yet been investigated. Along the research line of the mechanical treatment of asbestos, the aim of this study was to evaluate the effects of dry grinding in eccentric vibration mills on the structure, temperature stability, and fibre dimensions of tremolite asbestos from Val d’Ala, (Italy) and UICC standard anthophyllite asbestos from Paakkila mine (Finland) by varying the grinding time (30 s, 5 min, and 10 min). After grinding for 30 s to 10 min, tremolite asbestos and anthophyllite asbestos showed a decrease in dehydroxylation and breakdown temperatures due to the increase in lattice strain and the decrease in crystallinity. Moreover, after grinding up to 10 min, tremolite and anthophyllite fibres were all below the limits defining a countable fibre according to WHO.
Accumulation of Platinum Group Elements in Hydrogenous Fe–Mn Crust and Nodules from the Southern Atlantic Ocean
Authors: Berezhnaya Evgeniya D. , Dubinin Alexander V. , Rimskaya-Korsakova Maria N. , Safin Timur H.
Published: June 2018

Distribution of platinum group elements (Ru, Pd, Pt, and Ir) and gold in hydrogenous ferromanganese deposits from the southern part of the Atlantic Ocean has been studied. The presented samples were the surface and buried Fe–Mn hydrogenous nodules, biomorphous nodules containing predatory fish teeth in their nuclei, and crusts. Platinum content varied from 47 to 247 ng/g, Ru from 5 to 26 ng/g, Pd from 1.1 to 2.8 ng/g, Ir from 1.2 to 4.6 ng/g, and Au from less than 0.2 to 1.2 ng/g. In the studied Fe–Mn crusts and nodules, Pt, Ir, and Ru are significantly correlated with some redox-sensitive trace metals (Co, Ce, and Tl). Similar to cobalt and cerium behaviour, ruthenium, platinum, and iridium are scavenged from seawater by suspended ferromanganese oxyhydroxides. The most likely mechanism of Platinum Group Elements (PGE) accumulation can be sorption and oxidation on δ-MnO2 surfaces. The obtained platinum fluxes to ferromanganese crusts and to nodules are close and vary from 35 to 65 ng∙cm−2∙Ma−1. Palladium and gold do not accumulate in hydrogenous ferromanganese deposits relative to the Earth’s crust. No correlation of Pd and Au content with major and trace elements in nodules and crusts have been identified.
Near Real-Time Classification of Iron Ore Lithology by Applying Fuzzy Inference Systems to Petrophysical Downhole Data
Authors: Kitzig Maria C. , Kepic Anton , Grant Ashley
Published: June 2018

Fluctuating commodity prices have repeatedly put the mining industry under pressure to increase productiveness and efficiency of their operations. Current procedures often rely heavily on manual analysis and interpretation although new technologies and analytical procedures are available to automate workflows. Grade control is one such issue where the laboratory assay turn-around times cannot beat the shovel. We propose that for iron ore deposits in the Pilbara geophysical downhole logging may provide the necessary and sufficient information about rock formation properties, circumventing any need for real-time elemental analysis entirely. This study provides an example where petrophysical downhole data is automatically classified using a neuro-adaptive learning algorithm to differentiate between different rock types of iron ore deposits and for grade estimation. We exploit a rarely used ability in a spectral gamma-gamma density tool to gather both density and iron content with a single geophysical measurement. This inaccurate data is then put into a neural fuzzy inference system to classify the rock into different grades and waste lithologies, with success rates nearly equal to those from laboratory geochemistry. The steps outlined in this study may be used to produce a workflow for current logging tools and future logging-while-drilling technologies for real-time iron ore grade estimation and lithological classification.
Morphological Characteristics, Nutrients, and Bioactive Compounds of Zizania latifolia, and Health Benefits of Its Seeds
Authors: Yan Ning , Du Yongmei , Liu Xinmin , Chu Cheng , Shi John , Zhang Hongbo , Liu Yanhua , Zhang Zhongfeng
Published: June 2018

Zizania latifolia (tribe Oryzeae Dum., subfamily Oryzoideae Care, family Gramineae) is native to East Asian countries. The seeds of Z. latifolia (Chinese wild rice) have been consumed as a cereal in China for >3000 years. Z. latifolia forms swollen culms when infected with Ustilago esculenta, which is the second most-cultivated aquatic vegetable in China. The current review summarizes the nutrients and bioactive compounds of Z. latifolia, and health benefits of its seeds. The seeds of Z. latifolia contain proteins, minerals, vitamins, and bioactive compounds, the activities of which—for example, antioxidant activity—have been characterized. Various health benefits are associated with their consumption, such as alleviation of insulin resistance and lipotoxicity, and protection against cardiovascular disease. Chinese wild rice may be used to prevent and treat metabolic disease, such as diabetes, obesity, and cardiovascular diseases. Various compounds were isolated from the swollen culm, and aerial parts of Z. latifolia. The former suppresses osteoclast formation, inhibits growth of rat glioma cells, and may act as antioxidants and immunomodulators in drugs or foods. The latter exerts anti-fatigue, anti-inflammatory, and anti-allergic effects. Thus, Z. latifolia may be used to produce nutraceuticals and functional foods.
Interference of Quercetin on Astragalus Polysaccharide-Induced Macrophage Activation
Authors: Li Zhi-Peng , Liu Hong-Bing , Zhang Quan-Wei , Li Li-Feng , Bao Wan-Rong , Ma Dik-Lung , Leung Chung-Hang , Bian Zhao-Xiang , Lu Ai-Ping , Han Quan-Bin
Published: June 2018

Polysaccharides, which exert immunoregulatory effects, are becoming more and more popular as food supplements; however, certain components of ordinary foods could be reducing the polysaccharides beneficial effects. Quercetin, a flavonoid found in common fruits and vegetables, is one such component. This study investigated the effects of quercetin on Astragalus polysaccharide RAP induced-macrophage activation. The results show quercetin decreases the NO production and iNOS gene expression in RAW264.7 cells, and it inhibits the production of cytokines in RAW264.7 cells and peritoneal macrophages. Western blot analysis results suggest that quercetin inhibits the phosphorylation of Akt/mTORC1, MAPKs, and TBK1, but has no effect on NF-κB in RAP-induced RAW264.7 cells. Taken together, the results show that quercetin partly inhibits macrophage activation by the Astragalus polysaccharide RAP. This study demonstrates that quercetin-containing foods may interfere with the immune-enhancing effects of Astragalus polysaccharide RAP to a certain extent.
Iron Oxide Nanoparticles in Photothermal Therapy
Authors: Estelrich Joan , Busquets Maria Antònia
Published: June 2018

Photothermal therapy is a kind of therapy based on increasing the temperature of tumoral cells above 42 °C. To this aim, cells must be illuminated with a laser, and the energy of the radiation is transformed in heat. Usually, the employed radiation belongs to the near-infrared radiation range. At this range, the absorption and scattering of the radiation by the body is minimal. Thus, tissues are almost transparent. To improve the efficacy and selectivity of the energy-to-heat transduction, a light-absorbing material, the photothermal agent, must be introduced into the tumor. At present, a vast array of compounds are available as photothermal agents. Among the substances used as photothermal agents, gold-based compounds are one of the most employed. However, the undefined toxicity of this metal hinders their clinical investigations in the long run. Magnetic nanoparticles are a good alternative for use as a photothermal agent in the treatment of tumors. Such nanoparticles, especially those formed by iron oxides, can be used in combination with other substances or used themselves as photothermal agents. The combination of magnetic nanoparticles with other photothermal agents adds more capabilities to the therapeutic system: the nanoparticles can be directed magnetically to the site of interest (the tumor) and their distribution in tumors and other organs can be imaged. When used alone, magnetic nanoparticles present, in theory, an important limitation: their molar absorption coefficient in the near infrared region is low. The controlled clustering of the nanoparticles can solve this drawback. In such conditions, the absorption of the indicated radiation is higher and the conversion of energy in heat is more efficient than in individual nanoparticles. On the other hand, it can be designed as a therapeutic system, in which the heat generated by magnetic nanoparticles after irradiation with infrared light can release a drug attached to the nanoparticles in a controlled manner. This form of targeted drug delivery seems to be a promising tool of chemo-phototherapy. Finally, the heating efficiency of iron oxide nanoparticles can be increased if the infrared radiation is combined with an alternating magnetic field.
Cosmetics Preservation: A Review on Present Strategies
Authors: Halla Noureddine , Fernandes Isabel P. , Heleno Sandrina A. , Costa Patrícia , Boucherit-Otmani Zahia , Boucherit Kebir , Rodrigues Alírio E. , Ferreira Isabel C. F. R. , Barreiro Maria Filomena
Published: June 2018

Cosmetics, like any product containing water and organic/inorganic compounds, require preservation against microbial contamination to guarantee consumer’s safety and to increase their shelf-life. The microbiological safety has as main goal of consumer protection against potentially pathogenic microorganisms, together with the product’s preservation resulting from biological and physicochemical deterioration. This is ensured by chemical, physical, or physicochemical strategies. The most common strategy is based on the application of antimicrobial agents, either by using synthetic or natural compounds, or even multifunctional ingredients. Current validation of a preservation system follow the application of good manufacturing practices (GMPs), the control of the raw material, and the verification of the preservative effect by suitable methodologies, including the challenge test. Among the preservatives described in the positive lists of regulations, there are parabens, isothiasolinone, organic acids, formaldehyde releasers, triclosan, and chlorhexidine. These chemical agents have different mechanisms of antimicrobial action, depending on their chemical structure and functional group’s reactivity. Preservatives act on several cell targets; however, they might present toxic effects to the consumer. Indeed, their use at high concentrations is more effective from the preservation viewpoint being, however, toxic for the consumer, whereas at low concentrations microbial resistance can develop.
Flower-like Cu2SnS3 Nanostructure Materials with High Crystallinity for Sodium Storage
Authors: Fu Lin , Bi Zhen , Wei Benben , Huang Lanyan , Zhang Xuzi , Chen Zhihong , Liao Hua , Li Ming , Shang Chaoqun , Wang Xin
Published: June 2018

In this study, ternary Cu2SnS3 (CTS) nanostructure materials with high crystallinity were successfully prepared via a facile solvothermal method, which was followed by high-temperature treatment. The morphology of the as-synthesized samples is uniform flower-like spheres, with these spheres consisting of hierarchical nanosheets and possessing network features. Sodium storage measurements demonstrate that the annealed CTS electrodes have high initial reversible capacity (447.7 mAh·g−1 at a current density of 100 mA·g−1), good capacity retention (200.6 mAh·g−1 after 50 cycles at a current density of 100 mA·g−1) and considerable rate capability because of their high crystallinity and unique morphology. Such good performances indicate that the high crystallinity CTS is a promising anode material for sodium ion batteries.
Lutein and Zeaxanthin Isomers Protect against Light-Induced Retinopathy via Decreasing Oxidative and Endoplasmic Reticulum Stress in BALB/cJ Mice
Authors: Yu Minzhong , Yan Weiming , Beight Craig
Published: June 2018

Oxidative stress (OS) and endoplasmic reticulum stress (ERS) are the major factors underlying photoreceptor degeneration. Lutein, RR-zeaxanthin (3R,3’R-zeaxanthin) and RS (meso)-zeaxanthin (3R,3’S-RS- zeaxanthin) (L/Zi) could protect against cell damage by ameliorating OS in retina. In this study, we examined the effect of L/Zi supplementation in a mouse model of photoreceptor degeneration and investigated whether the treatment of L/Zi ameliorated OS and ERS. BALB/cJ mice after light exposure were used as the animal model. The protective effects of L/Zi were observed by electroretinography (ERG) and terminal deoxyuridine triphosphate nick-end labeling (TUNEL) analysis. The underlying mechanisms related to OS and ERS were explored by Western blotting. After L/Zi treatment, the ERG amplitudes were significantly higher, and the number of TUNEL-positive cells was significantly reduced compared to that of the vehicle group. Western blotting results revealed that OS was ameliorated according to the significant downregulation of phosphorylated c-Jun N-terminal kinase (p-JNK), and significant upregulation of nuclear factor erythroid 2-related factor 2 (Nrf2). In addition, ERS was reduced according to the significant downregulation of 78 kDa glucose-regulated protein (GRP78), phosphorylated protein kinase RNA-like endoplasmic reticulum kinase (p-PERK), activating transcription factor 4 (ATF4) and activating transcription factor (ATF6). Our data shows that L/Zi provided functional and morphological preservation of photoreceptors against light damage, which is probably related to its mitigation of oxidative and endoplasmic reticulum stress.
Raloxifene/SBE-β-CD Inclusion Complexes Formulated into Nanoparticles with Chitosan to Overcome the Absorption Barrier for Bioavailability Enhancement
Authors: Wang Zaihua , Li Yan
Published: June 2018

Raloxifene (RXF) is a hormone-like medication used for treating postmenopausal osteoporosis and estrogen-dependent breast cancer, yet associated with bad low bioavailability due to poor solubility. This study was intended to develop cyclodextrin/chitosan nanoparticles (ccNPs) for oral delivery of RXF in order to enhance the oral bioavailability. RXF-loaded ccNPs (RXF-ccNPs) were prepared by cyclodextrin inclusion followed by complexation with chitosan. RXF-ccNPs were fully characterized by particle size, morphology and in vitro drug release. The oral delivery efficacy and transepithelial transport potential were evaluated by pharmacokinetics, in situ single-pass intestinal perfusion, cellular uptake and ex vivo imaging. The resulting RXF-ccNPs were around 165 nm in particle size with a narrow distribution. The oral bioavailability of RXF was enhanced by 2.6 folds through ccNPs compared to RXF suspensions in rats. It was shown that RXF-ccNPs could improve the intestinal permeability of RXF, increase the cellular uptake of RXF and facilitate its transport across the absorptive epithelia. The results indicate that our developed ccNPs based on sulfobutylether-β-cyclodextrin and oligochitosan are a promising vehicle to orally deliver poorly water-soluble drugs over and above RXF.
Loading IR820 Using Multifunctional Dendrimers with Enhanced Stability and Specificity
Authors: Liu Hui , Wang Jingjing
Published: June 2018

Cyanine dyes are promising candidates in biomedical applications. Although various delivery systems have been developed to enhance their properties, their dendrimer-based delivery systems are seldom investigated. Herein, amine-terminated generation 5 poly(amidoamine) (G5.NH2) dendrimers and new indocyanine green (IR820) dyes were chosen as models to study the loading ability of dendrimers for cyanine dynes. G5.NH2 dendrimers were pre-modified with arginine-glycine-aspartic (RGD) peptides, poly(ethylene glycol) chains, and acetyl groups to be endowed with cancer cell specificity and biocompatibility. The formed Ac-PR dendrimers were used to load IR820, followed by thorough characterization. The loaded number of IR820 was estimated to be 6.7 per dendrimer. The stability of IR820 was improved through dendrimer loading, which was proved by their UV-vis spectra under different kinds of storage conditions. In addition, the formed Ac-PR dendrimers can retain the loaded IR820 effectively. Their cytocompatibility was desirable under the studied conditions. Their cellular uptake behaviors were demonstrated to be enhanced by RGD modification, showing concentration-, co-incubation time-, and αvβ3 integrin receptor-dependent properties, displaying a cytoplasm-location. The findings from this work demonstrated the versatile loading and delivery capacity of dendrimers for near-infrared (NIR) dyes, providing fundamental data for the development of dendrimer/NIR dye systems for biomedical applications, especially for cancer theranostic applications.
Organocatalytic Stereoselective Cyclic Polylactide Synthesis in Supercritical Carbon Dioxide under Plasticizing Conditions
Authors: Mase Nobuyuki , Moniruzzaman  , Yamamoto Shoji , Nakaya Yoshitaka , Sato Kohei , Narumi Tetsuo
Published: June 2018

Cyclic polylactide (cPLA) is a structural isomer of linear polylactide (PLA) although it possesses unique functionalities in comparison to its linear counterpart. Hitherto, the control of stereochemical purity in conventional cPLA synthesis has not been achieved. In this study, highly stereochemically pure cPLA was synthesized in the absence of a metal catalyst and organic solvent, which required high consumption of the residual monomer. The synthesis was conducted in supercritical carbon dioxide under CO2 plasticizing polymerization conditions in the presence of an organocatalyst and thiourea additives. In comparison with the stereocomplexes synthesized through conventional methods, cPLA from l-lactide (cPLLA) and cPLA from d-lactide (cPDLA) were synthesized with higher stereochemical purity and improved thermal stability. Moreover, the method presented herein is environmentally friendly and thus, applicable on an industrial level.
Remote Sensing of Phytoplankton Size Class in Northwest Atlantic from 1998 to 2016: Bio-Optical Algorithms Comparison and Application
Authors: Liu Xiaohan , Devred Emmanuel , Johnson Catherine
Published: June 2018

Phytoplankton community structure and phytoplankton size class (PSC) are linked to ecological and biogeochemical changes in the oceanic environment. Many models developed to obtain the fraction of PSCs from satellite remote sensing have only been evaluated in open oceans, and very limited effort has been carried out to report on the performance of these PSC models in productive continental shelf waters. In this study, we evaluated the performance of nine PSC models in the coastal Northwest Atlantic (NWA) by comparison of in situ phytoplankton pigment measurements with coincidental satellite data from the Sea-Viewing Wide Field-of-View Sensor (SeaWiFS), Moderate-resolution Imaging Spectroradiometer (MODIS), and the Visible Infrared Imaging Radiometer Suite (VIIRS). Our results show that no PSC model retrieved all three phytoplankton size classes (pico-, nano-, and micro-phytoplankton) with reliable accuracy in the region of interest. In particular, these PSC models showed poor performance for retrieval of the picophytoplankton fraction of total phytoplankton in our study region, which could be related to the under-representation of pico-dominated samples in the productive waters of the NWA. For the accuracy of retrieved microphytoplankton and combined nano–pico phytoplankton fraction, the regional model developed by Devred et al. (2011) yielded the best result, followed by the model of Brewin et al. (2011). The model of Devred et al. (2011) was applied to satellite-derived chlorophyll-a concentration from the Ocean Color Climate Change Initiative (OC-CCI) archive in the NWA from 1998 to 2016. We report solely on the microphytoplankton biomass and fraction given the inverse relationship that exists with the nano–pico class. The multi-decadal trend along with the deseasonalized trend of microphytoplankton fraction was computed and analyzed for six biogeochemical provinces located in the NWA. Over the 19-year time series, there were significant, positive trends for four of the six provinces, with a slope of 0.36%·yr−1 in the Northwest Continental Shelf (NWCS), 0.25%·yr−1 in the Arctic Waters (ARCT), 0.12%·yr−1 in the Slope Waters (SW) and 0.06%·yr−1 in the Gulf Stream (GFST). Strong positive anomalies of microphytoplankton fraction were found in winter months in NWCS between 2009 and 2014, which could be associated with changes in environmental factors.
Design for Manufacture and Assembly Oriented Design Approach to a Curtain Wall System: A Case Study of a Commercial Building in Wuhan, China
Authors: Chen Ke , Lu Weisheng
Published: June 2018

A curtain wall system (CWS) is one of the most popular elements for the external walls of large, multistory buildings. Applying the design for manufacture and assembly (DfMA) principles to the design of a CWS aims to increase the quality, sustainability, and cost efficiency associated with the assembly of the CWS. Studies reporting a DfMA-oriented design approach to CWSs are extremely rare. This paper reports a case study of a successful application of a DfMA-oriented design approach to a CWS in a commercial building in Wuhan, China. The case study provides valuable information about how DfMA could be applied to the construction industry. Through interviews with key project participants and on-site observations, the benefits of a DfMA-oriented CWS design were revealed, including decreased material cost and waste, reduced on-site assembly time, and improved quality and aesthetic performance of the CWS. It was also found that an operative multidisciplinary team underpinned the success of DfMA application in the case project, which, however, might be held back by the absence of any use of digital, parametric design technologies during the design process.
Soil Fertility Management by Transition Matrices and Crop Rotation: On Spatial and Dynamic Aspects in Programming of Ecosystem Services
Authors: Nuppenau Ernst-August
Published: June 2018

This paper deals with crop rotation as a method to improve soil fertility and control pests from an economic point of view. It outlines a new framework for modelling of more sustainable decision-making of farmers under the auspices of ecosystem services. It is intended for practical application in extension and farmer communication to show values of rotations referring to natural capital. In the past farmers created complex rotations to benefit from ecological processes which enabled them to control natural pests (at least partly), to build soil fertility on recycling of organics (humus formation), and to promote pollination (including wild bees and other insects) and water retention (diverse water requests of different crops). Farmers which were accommodating cropping orders in small parcels of fields used long lists of crop sequences and offered mixed farming systems: this was a major feature of agriculture. Cropping orders evolved from necessity and were followed as rules. Today we are faced with large fields and monoculture, instead, and ecosystem services are diminished. Usually, attempts to recognize economic pay-offs from rotation through modelling are meagre because of complexity. We address the issue of complexity by suggesting a new flexible type of modelling crop rotations (dynamic optimization) which condenses ecological information into matrices. A newly-hosted transfer matrix shall delineate the impacts of cropping patterns in period t to fertility of land in t + 1. Categorizing different states of nature (which have to be brought in line with farmers’ knowledge of externalities), it can be implemented in models on rotation decision.
Regional Cooperation Ecosystem: Case of the Žilina Self-Government Region (Slovak Republic)
Authors: Soviar Jakub , Holubčík Martin , Vodák Josef
Published: June 2018

The paper deals with the topic of the cooperation ecosystem in the Žilina higher self-government region (HSGR). The results are mainly from our research about cooperation in the region. According to the research results, the most developed areas of the cooperation are: the supplier–customer relationships, techniques and technology, education, legal service, marketing, transport, research and development. Research also finds more possible capacity for further cooperating connections. For example, the University of Žilina (UNIZA) and HSGR are natural cooperation centers and are both highly sought for as cooperation partners. Based on our findings we designed a model of the cooperation ecosystem, or cooperation platform in the Žilina self-government region. This platform should be formed by UNIZA and HSGR and other organizations for development of new cooperation projects in the region. Thanks to the dynamic and sustainable character of the platform it can easier react to changes on the market.
Woody Encroachment as a Social-Ecological Regime Shift
Authors: Luvuno Linda , Biggs Reinette , Stevens Nicola , Esler Karen
Published: June 2018

African savannas are increasingly affected by woody encroachment, an increase in the density of woody plants. Woody encroachment often occurs unexpectedly, is difficult to reverse, and has significant economic, cultural and ecological implications. The process of woody encroachment represents a so-called regime shift that results from feedback loops that link vegetation and variables such as fire, grazing and water availability. Much of the work on woody encroachment has focused on the direct drivers of the process, such as the role of fire or grazing in inhibiting or promoting encroachment. However, little work has been done on how ecological changes may provide feedback to affect some of the underlying social processes driving woody encroachment. In this paper, we build on the ecological literature on encroachment to present a qualitative systems analysis of woody encroachment as a social-ecological regime shift. Our analysis highlights the underlying indirect role of human population growth, and we distinguish the key social-ecological processes underlying woody encroachment in arid versus mesic African savannas. The analysis we present helps synthesize the impacts of encroachment, the drivers and feedbacks that play a key role and identify potential social and ecological leverage points to prevent or reverse the woody encroachment process.
Temporal Stability of Groundwater Depth in the Contemporary Yellow River Delta, Eastern China
Authors: Wang Ruiyan , Huston Simon , Li Yuhuan , Ma Huiping , Peng Yang , Ding Lihua
Published: June 2018

Sustainable development calls for the wise use of groundwater resources. Of particular concern is saline intrusion into productive agricultural land, which is contiguous with densely populated coastal settlements. To reverse saline intrusion in such coastal regions, information about the groundwater depth in terms of its spatio-temporal variability is essential. Using survey data from 2004 to 2007, the research revealed the temporal variation characteristics of groundwater depth in the Contemporary Yellow River Delta. It explored the temporal stability characteristics of groundwater depth by using the coefficient of variation, Spearman rank correlation coefficient, and average relative deviation and standard deviation, and confirmed that the representative point reflected the average groundwater depth of the study area. Results showed that spatial variation of the groundwater depth in the study area was medium, but the variation coefficient of groundwater depth showed the seasonal changes. The spatial variation coefficient was largest in the dry season; the other months were relatively stable. The groundwater depth in the study area had strong temporal stability. The correlation between the Spearman rank correlation coefficient and the time lags showed that the spatial pattern of groundwater depth in the study area was similar across two or three years but the similarity weakened beyond this period. The representative points of the whole area showed a good linear correlation, and were spatially concentrated. In different years or time periods, the representative points were not the same but belonged to the medium groundwater depth grade in the area. The study provides useful guidance for Yellow River irrigation, preventing saline intrusion and the restoration of saline-alkali soils. It offers a theoretical basis for identifying regional satellite groundwater depth monitoring points.
The Change Mechanism of Human-Environment Interactions from the Perspective of Contextualization: A Case Study of the Honghe Hani Rice Terraces as a World Cultural Heritage Site
Authors: Hua Honglian , Zhou Shangyi , Ding Zhiqiang , Pan Yujun
Published: June 2018

The importance of special contexts and historical contingency in explaining the mechanism of human-environment interactions is being increasingly emphasized by human geographers. However, their studies lack appropriate theories and an operational framework to apply a “contextualization” epistemology to explain human-environment interactions. Based on the theory of event ecology, this study establishes a new framework and illustrates it by presenting a case study of the world heritage site of the Honghe Hani Rice Terraces (HHRT). This case study demonstrates that in the HHRT, although it is overwhelmingly believed that the sharp increase in the numbers of restaurants and hotels resulted in increased water usage and, consequently, a decreased amount of water for irrigation, in fact, the dry local terraces were mainly caused by continuously decreased precipitation, the planting of water-consuming crops in forests and deforestation in recent years. These factors were not objectively considered primarily because the unbalanced opportunities for residents to participate in tourism led to significant conflicts in the local community. Thus, the locals exaggerated the contribution of tourism to the dry terraces because they wanted the outsiders pay more attention to these conflicts. This study suggests that the new research framework can effectively avoid presupposition and presumption caused by the prior cognition among researchers and local people to objectively recognize the causes of changes in human-environment interactions. In addition, this study demonstrates that it is necessary to analyze the mechanism for changes in human-environment interactions in detail from the perspectives of local political, economic, and social contexts to enhance the sustainable development of cultural landscape heritage sites.
Corporate Social Responsibility (CSR): A Survey of Topics and Trends Using Twitter Data and Topic Modeling
Authors: Chae Bongsug (Kevin) , Park Eunhye (Olivia)
Published: June 2018

Corporate social responsibility (CSR) is an essential business practice in industry and a popular topic in academic research. Several studies have attempted to understand topics or categories in CSR contexts and some have used qualitative techniques to analyze data from traditional communication channels such as corporate reports, newspapers, and websites. This study adopts computational content analysis for understanding themes or topics from CSR-related conversations in the Twitter-sphere, the largest microblogging social media platform. Specifically, a probabilistic topic modeling-based computational text analysis framework is introduced to answer three questions: (1) What CSR-related topics are being communicated in the Twitter-sphere and what are the prevalent topics or themes in CSR conversation? (topic prevalence); (2) How are those topics interrelated? (topic correlation); (3) How have those topics changed over time? (topic evolution). The topic modeling results are discussed, and the direction for future research is presented.