bluuebunny/crossref_metadata_2025 huggingface dataset:
Optimal Bidding Strategies for Wind-Thermal Power Generation Rights Trading: A Game-Theoretic Approach Integrating Carbon Trading and Green Certificate Trading
Authors: Shen Meina , Cheng Runkun , Liu Da
Published: August 2024

In response to the challenges of low wind power consumption and high pollution emissions from thermal power, the implementation of wind-thermal power generation rights trading is a proactive attempt to reduce wind power curtailment and promote its consumption. This study first regards the alternating bidding process between the two parties as a dynamic game, using the Rubinstein bargaining game model to determine the incremental profit allocation and optimal bidding for both parties in power generation rights trading. Secondly, an energy conservation and emission reduction model is constructed to analyze the benefits from the perspectives of standard coal consumption saving and the carbon emission reduction caused by power generation rights trading. Finally, a combined trading revenue model is established to analyze the final profit of both parties involved in the trading. The results show that the combined trading of wind-thermal power generation rights, incorporating carbon trading and green certificate trading, can effectively promote coal consumption savings in thermal power units and reduce the carbon emissions of the power industry. Moreover, it significantly increases the final profit for both parties, stimulating the enthusiasm of generators for participating in power generation rights trading, and ultimately promoting wind power consumption.
Posterior Spinal Fusion for Severe Kyphosis in a Child with Gaucher Disease: A Case Report and Review of the Literature
Authors: Zhao Tengfei , Zhang Ning , Chen Linwei , Li Jun , Chen Qixin , Li Fangcai
Published: August 2024

Background: Skeleton involvement is one of the most significant aspects of Gaucher disease (GD). However, the treatment for spinal involvement in GD among patients undergoing enzyme replacement therapy (ERT) is poorly characterized. We present a case of progressive kyphotic spinal deformity in a young child caused by vertebral involvement, which was managed by posterior spinal fusion without anterior spinal release under ERT. Case presentation: This is a retrospective study. A 10-year-old boy presenting with progression kyphosis (thoracic kyphotic angle of 113°) associated with type-IIIb GD had undergone posterior spinal fusion with segmental pedicle screw fixation (from T6-L3) and Ponte osteotomy. The patient went back to school without further brace protection. Proximal junctional kyphosis (PJK) was observed at 4 months postoperatively. Revision surgery was performed to prevent neurological impairment. Additional posterior spinal fusion from T2–T6 and decompressive laminectomy were performed during the revision surgery. A 2-year follow-up showed no recurrence of PJK and solid fusion was achieved in the patient under ERT and brace protection. Conclusions: Posterior spinal fusion without anterior spinal release is a good treatment option for severe spinal deformity in patients with GD. However, the fusion level and reinforced fixation require careful consideration. Revision surgery and brace protection is needed as long as PJK is observed.
The Evolution of Robotic Surgery through the Machine Design Innovation
Authors: Ragusa Alberto , Prata Francesco , Iannuzzi Andrea , Tedesco Francesco , Cacciatore Loris , Brassetti Aldo , Muto Giovanni , Scarpa Roberto Mario , Papalia Rocco
Published: August 2024

To date, robotic surgery has gained much popularity, impacting deeply on surgical fields such as genitourinary system branches, general surgery, and cardiac surgery. We aim to outline the landscape of robotic surgery, focusing on design improvements, which have improved both the technical skills of surgeons and the outcomes of minimally invasive technique for patients. A thorough narrative literature review was conducted on PubMed/MEDLINE, employing keywords such as “robotic surgical system”, “robotic surgical device”, and “robotics AND urology”. Furthermore, the reference lists of the retrieved articles were scrutinized. The analysis focused on urological surgical systems from the 2000s to the present day. Beginning with the daVinci® Era in the 2000s, new robotic competitors, including Senhance®, Revo-I®, Versius®, Avatera®, Hi-notori®, and HugoTM RAS, have entered the medical market. While daVinci® has maintained a high competitiveness, even more new platforms are now emerging in the medical market with new intriguing features. The growing competition, driven by unique features and novel designs in emerging robotic technologies, has the potential to improve application fields, enhance diffusion, and ameliorate the cost effectiveness of procedures. Since the impact of these new surgical technologies on different specialties and healthcare systems remains unclear, more experience and research are required to define their evolving role.
Risk Factors Associated with Hepatitis C Subtypes and the Evolutionary History of Subtype 1a in Mexico
Authors: Laguna-Meraz Saul , Jose-Abrego Alexis , Roman Sonia , Leal-Mercado Leonardo , Panduro Arturo
Published: August 2024

The Hepatitis C Virus (HCV), with its diverse genotypes and subtypes, has significantly impacted the health of millions of people worldwide. Analyzing the risk factors is essential to understanding the spread of the disease and developing appropriate prevention strategies. This study aimed to identify risk factors associated with HCV subtype transmission and calculate the emergence time of subtype 1a in Mexico. A cross-sectional study was conducted from January 2014 to December 2018, involving 260 HCV-infected adults. HCV infection was confirmed via Enzyme-Linked Immunosorbent Assay, and viral load was measured by real-time PCR. Genotyping/subtyping tools were the Line Probe Assay and Sanger sequencing of the non-structural region 5B (NS5B). The most frequent HCV subtype was 1a (58.5%), followed by subtypes 1b (19.2%), 3a (13.1%), 2b (5.4%), 2a/2c (2.7%), 2a (0.8%), and 4a (0.4%). Intravenous drug use and tattoos were significant risk factors for subtypes 1a and 3a, while hemodialysis and blood transfusion were linked with subtype 1b. For the evolutionary analysis, 73 high-quality DNA sequences of the HCV subtype 1a NS5B region were used, employing a Bayesian coalescent analysis approach. This analysis suggested that subtype 1a was introduced to Mexico in 1976, followed by a diversification event in the mid-1980s. An exponential increase in cases was observed from 1998 to 2006, stabilizing by 2014. In conclusion, this study found that HCV subtypes follow distinct transmission routes, emphasizing the need for targeted prevention strategies. Additionally, the findings provide valuable insights into the origin of HCV subtype 1a. By analyzing the history, risk factors, and dynamics of the HCV epidemic, we have identified these measures: limiting the harm of intravenous drug trafficking, enhancing medical training and infrastructure, and ensuring universal access to antiviral treatments. The successful implementation of these strategies could lead to an HCV-free future in Mexico.
Total Laparoscopic Colopexy for the Treatment of Recurrent Rectal Prolapses in Three Cats
Authors: Guadalupi Marta , Piemontese Claudia , Stabile Marzia , Dizonno Rosanna , Staffieri Francesco , Lacitignola Luca
Published: August 2024

The use of minimally invasive methods has grown in popularity due to decreased postoperative morbidity and a quicker recovery. Colopexy is a surgical method that includes the permanent adhesion of the colonic seromuscular layer to the abdominal wall to avoid rectal prolapses in cats and dogs with viable prolapsed tissues. In this case series, we describe the treatment of three cats with total laparoscopic colopexy (TLC) for recurrent rectal prolapses. A non-incisional colopexy was created by suturing the colon to the abdominal wall with a barbed suture. There were no intraoperative complications and a 6-month follow-up revealed no prolapse recurrence. Our study demonstrates that TLC approaches are feasible, safe, and free of problems when used to treat recurrent rectal prolapses in cats, although a larger caseload is required to validate the results obtained from our reported cases.
A Spectral Precursor Indicative of Artificial Water Reservoir-Induced Seismicity: Observations from the Xiangjiaba Reservoir, Southwestern China
Authors: Fu Ziguo , Chen Fei , Deng Jianhui , Zhao Siyuan , Dai Shigui , Zhu Jun
Published: August 2024

Spectral analysis is an effective tool for processing seismic signals, particularly when time-domain characteristics are challenging to capture. In this study, we developed a method using P-wave signals to calculate the power spectrum, enabling the estimation of two spectral parameters—peak frequency and shape factor—for earthquakes recorded by regional seismic networks in the Xiangjiaba (XJB) reservoir area from 2010 to 2015. The temporal evolution of the two spectral parameters was analyzed, revealing that the mean values of individual spectral parameters remain relatively stable despite variations in reservoir water levels. However, a notable increase in the ratio of the shape factor to the peak frequency is observed when the XJB reservoir reaches its maximum water level, suggesting its potential as a precursor indicator for reservoir-induced seismicity (RIS). Furthermore, we performed spatial interpolation on the spectral parameters, and the results show that reservoir impoundment significantly influences the spatial distribution of these parameters. In addition, several regions between the two faults in the tail section of the XJB reservoir exhibit an elevation in the proposed precursor indicator. This study presents a new approach for monitoring and early warning of RIS.
Preparation of Fe-Modified Diatomite-Based Ceramsite for Efficient Phosphate Adsorption: Utilizing Diatomite’s Distinctive Porous Structure and Surface Silanol Groups
Authors: Chen Zhichao , Min Yulin , Zhao Xin , Shi Penghui , Lu Hongxiu
Published: August 2024

Ceramsites are extensively employed as substrates for adsorbents in studies focused on phosphorus adsorption, leaving ceramsites crafted from diatomite less explored. Diatomite-based ceramsite, with its distinct porous architecture and surface silanol functionalities, is adept at supporting a variety of metal oxides, presenting a distinct advantage over other ceramsite variants. In light of this, the present study embarked on producing diatomite-based ceramsite using diatomite as the foundational material, subsequently enhancing it through the incorporation of Fe, thus yielding an Fe-modified diatomite-based ceramsite. Through adsorption testing, the modified ceramsite demonstrated a significantly improved adsorption capacity of 4.06 mg P/g, marking a substantial enhancement from the initial capacity of 0.9 mg P/g. The process of phosphorus adsorption exhibited a strong alignment with the Langmuir isotherm model and the pseudo-second-order kinetic model. In-depth analyses employing XRD, FTIR, zeta potential, and XPS techniques have revealed that the principal mechanisms driving the adsorption process are centered on interactions involving electrostatic forces, the formation of chemical precipitates, and the exchange of ligands. This investigation not only opens new avenues for the application of diatomite-based ceramsite but also lays down a theoretical foundation for its modification, thereby enriching the spectrum of its utility.
Advancing Sustainable Transportation Education: A Comprehensive Analysis of Electric Vehicle Prototype Design and Fabrication
Authors: Ravi Rajesh , Belkasmi Merouan , Douadi Oumaima , Faqir Mustapha , Essadiqi Elhachmi , Gargab Fatima Zohra , Ezhilchandran Manoranjitham , Kasinathan Padmanathan
Published: August 2024

The global shift towards electric vehicles (EVs) has necessitated a paradigm shift in engineering education, emphasizing hands-on experiences and innovative learning approaches. This review article presents a comprehensive analysis of the design and fabrication process of an educational EV prototype, highlighting its significance in preparing future engineers for the rapidly evolving EV industry. The article delves into the historical development and recent trends in EVs, providing context for the growing importance of practical skills in this field. A detailed examination of the key components and systems in modern EVs, such as battery packs, electric motors, transmission systems, and chassis design, lays the foundation for understanding the complexities involved in EV prototype development. The methodology section explores the research approach, conceptual design, simulations, material selection, and construction techniques employed in the creation of an educational EV prototype. The evaluation and testing phase assesses the prototype’s performance, safety, and reliability, offering valuable insights into the lessons learned and areas for improvement. The impact of such projects on engineering education is discussed, emphasizing the importance of hands-on learning experiences and interdisciplinary collaboration in preparing students for future careers in the EV industry. The article concludes by addressing common challenges faced during EV prototype projects and providing recommendations for future educational initiatives in this field.
Transition toward Sustainability in the Moroccan Food System: Drivers, Outcomes, and Challenges
Authors: Benayad Asmaa , Bikri Samir , Hindi Zakia , Lafram Amina , Belfakira Chaimaa , Yassif Fatima-Zahra , El Bilali Hamid , Aboussaleh Youssef
Published: August 2024

Nowadays, food systems are undergoing major transformations to achieve the 2030 Sustainable Development Goals (SDGs). However, there are a lack of comprehensive reviews on this topic in developing countries. This work highlights food systems’ transition towards sustainability, focusing on Morocco. It was carried out through searching, selecting, evaluating, and synthesizing existing relevant scholarly and gray literature. In Morocco, a meaningful transition towards sustainability is being guided and carried out on several levels, despite numerous challenges, e.g., inability to cope with the detrimental effects of climate change and escalating water scarcity constitute fundamental problems. However, there are conflicting views on the outcomes of food system transformation. Some studies showed that Morocco has increased its agri-food export and reduced poverty to less than 5% of the population over the past decade; the proportion of wasted and malnourished children has declined from 25 to 15% and 4 to 3%, respectively, and the 2023 Global Hunger Index (GHI) showed a score of 9.0. Other studies showed that North Africa has entered a food security crisis; specifically, food inflation has reached unprecedented levels in Morocco. This paper provides valuable insights for policymakers and planners to design evidence-based policies and strategies to boost sustainable development in Morocco.
Digital Communication Strategy Start-Up Psychology Service Bureau in Improving Consumer Self-Development
Authors: Purwaningwulan Melly Maulin , Rizki Muhammad Dwi
Published: August 2024

This study aims to determine the Start-Up Digital Communication Strategy of the Psychology Service Bureau in Improving Consumer Self-Development. To answer the objectives of the sub-focus of research includes Defining Communicators, Setting Targets & Analysis of Audience Needs, Composing Messages and Selecting Media & Communication Channels. This study uses a qualitative approach and descriptive research methods. Data collection techniques through in-depth interviews, non-participant observation and documentation. Using purposive sampling technique, 6 informants were obtained. Test the validity of the data using triangulation and member checking. The results of the study show that communicators meet professional criteria in the field of psychology and have a track record as a speaker or motivator. Target audience needs and needs analysis refers to the business model canvas, evaluation results of previous activities and team brainstorming. The nature of the message conveyed is informative and educative. Two-sided issue message delivery techniques and message appeals used rational, emotional and motivational message appeals. Various social media are used to promote program activities and after implementation, YouTube is used as a publication medium. The conclusion of the research is that the Start-Up Digital Communication Strategy of the Psychology Service Bureau has increased the self-development of its consumers, the long-term impact of building psychological social support for the younger generation in dealing with and solving problems.
Digitalization in Bulgarian science education: a comparative analysis of the state of the art
Authors:   Faculty of Chemistry and Pharmacy, University of Sofia St. Kliment Ohridski, 1 James Bourchier Blvd., 1164 Sofia, Bulgaria, Boiadjieva E. , Tafrova-Grigorova A.
Published: August 2024

The paper discusses the use of digital technologies (DT) in Bulgarian school science education through a review and analysis of national and international studies. Both the strengths and weaknesses of the application of DT in the Bulgarian school in a comparative plan with other European countries are highlighted. The findings show that the digital competence of Bulgarian students and teachers related to DigComp and DigCompEdu frameworks is generally lower than the European average despite the confidence in their digital skills. Problematic areas include creating and modifying digital content, collaboration among teachers, identifying fake news, assessing student progress, implementing constructivist approaches in e-learning. The quality of continuing teacher education for digital competences is also a concern. Nevertheless, many Bulgarian teachers express satisfaction with their work in distance learning and believe that the use of DT enhances their lessons. Analysis of digital technology use and student learning achievements in science education shows no clear evidence of a correlation. However, there are potential positive effects of using computers as a supplement to traditional instruction rather than as an alternative to it.
PLA/PVP/bio-synthesized hydrozincite nanocomposite films – photocatalytic and antibacterial activity
Authors:   Institute of Mineralogy and Crystallography “Аcad. I. Kostov”, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., Bl. 107, 1113 Sofia, Bulgaria, Zaharieva K. L. , Dimova S. S. ,   Institute of Polymers, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., Bl. 103A, 1113 Sofia, Bulgaria, Eneva R. T. Eneva ,   The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., Bl. 26, 1113 Sofia, Bulgaria, Hubenov V. N. ,   The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., Bl. 26, 1113 Sofia, Bulgaria, Stambolova I. D. ,   Institute of General and Inorganic Chemistry, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., Bl. 11, 1113 Sofia, Bulgaria, Stoyanova D. D. ,   Institute of General and Inorganic Chemistry, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., Bl. 11, 1113 Sofia, Bulgaria, Ublekov F. S. ,   Institute of Polymers, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., Bl. 103A, 1113 Sofia, Bulgaria, Dimitrov O. S. ,   Institute of Electrochemistry and Energy Systems, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., Bl. 10, 1113 Sofia, Bulgaria, Penchev H. P. ,   Institute of Polymers, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., Bl. 103A, 1113 Sofia, Bulgaria
Published: August 2024

Nanocomposite films based on biodegradable polylactic acid (PLA) and PLA/polyvinylpyrrolidone (PVP) with embedded stabilized Hydrozincite powder were synthesized by solution casting method. The Hydrozincite was prepared by plant extract-mediated hydrothermal synthesis. Powder X-ray diffraction analysis and Fourier-transform infrared spectroscopy were used to establish the phase composition and structure of the films. The photocatalytic activity of the obtained nanocomposite films was tested and compared in the reaction of degradation of Malachite Green dye under UV illumination. The photocatalytic results revealed that the PLA/PVP-containing Hydrozincite nanocomposite film leads to a higher degree of degradation of the Malachite Green dye (87 %) after 150 minutes in comparison to that of PLA/Hydrozincite (31%). The antibacterial activity of the prepared nanocomposite films against an Escherichia coli control strain was also discussed. The investigated biocomposite films demonstrated high antibacterial efficiency. It was found that the concentration of viable bacterial cells decreases by about 99% after 1 hour of contact time for both investigated composites.
Preparation and antimicrobial activity of silver nanoparticles impregnated with halloysite clay
Authors:   Institute of Mineralogy and Crystallography “Аcad. I. Kostov”, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., Bl. 107, 1113 Sofia, Bulgaria, Zaharieva K. L. , Eneva R. T. ,   The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., Bl. 26, 1113, Sofia, Bulgaria, Mitova S. L. ,   The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., Bl. 26, 1113, Sofia, Bulgaria, Dimitrov O. S. ,   Institute of Electrochemistry and Energy Systems, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., Bl. 10, 1113 Sofia, Bulgaria, Penchev H. P. ,   Institute of Polymers, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., Bl.103A, 1113 Sofia, Bulgaria
Published: August 2024

In the present work, nanotubular halloysite clay was ultrasonically treated and impregnated with silver nanoparticles. The citrate surface-stabilized silver nanoparticles dispersion was prepared using an effective method of electrochemical synthesis. The elemental and phase composition, and the structure of the obtained AgNPs-impregnated and pristine halloysite were investigated by various methods such as X-ray fluorescence (XRF), powder X-ray diffraction analyses and Fourier-transform infrared spectroscopy. The Ag-loaded halloysite sample with 0.454 wt.% silver content was confirmed by the XRF analysis. The antimicrobial activity of the pristine and the AgNPs-impregnated halloysite clay was tested against Escherichia coli ATCC 25922 (Gram-negative) and Bacillus subtilis ATCC 6633 (Gram-positive) strains. The results show that pure halloysite does not exhibit antibacterial activity. The AgNPs-impregnated halloysite demonstrates antibacterial activity against Escherichia coli and Bacillus subtilis with only bacteriostatic effect.
Schizocommunin analogues and derivatives as G-quadruplex ligands and anticancer agents
Authors:   Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., Block 9, 1113 Sofia, Bulgaria, Bakalova S.M. , Kaneti J. ,   Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., Block 9, 1113 Sofia, Bulgaria
Published: August 2024

G-quadruplexes (GQs) have become valid targets for anticancer efforts in the recent couple of decades due to their extremely multifaceted biological functions. Our goal is to quantify interactions within GQs, as well as their interactions with potential ligands (Ls). As secondary nucleic acid (NA) structures, GQs may be understood as a central channel of stacked G-quartets, interlinked into a G-stem (GS) with nucleotide loops. Computational data on full GQ energetics are, however, increasingly noisy. Therefore, we have chosen to simplify our GQ model by stripping it off all nucleotide residues into a “naked” GQ. The GQ-L stacking model allows computing of intrinsic interaction energies, as well as external ligand stacking affinities with “chemical precision”. To relate computed ligand – G4 affinities to their biological activity, we use published inhibitory activities (IC50 values) of several groups of heterocycles. Some of our results provide a good linear relationship between ligand stacking affinities to GQ, calculated by quantum chemical DFT methods, and corresponding log(IC50) values. Herewith we discuss the obtained results in terms of a mechanism of anticancer activity of heterocyclic ligands via complexation with GQs and thereby control of GQ cell regulatory activity.
Association of Dialysate Bicarbonate with Arrhythmia in the Monitoring in Dialysis Study
Authors: Ravi Katherine Scovner , Tumlin James A. , Roy-Chaudhury Prabir , Koplan Bruce A. , Costea Alexandru I. , Kher Vijay , Williamson Don , McClure Candace K. , Charytan David M. , Mc Causland Finnian R. ,   on behalf of the MiD Investigators and Committees
Published: August 2024

Key Points

Sudden cardiac death is a major concern for hemodialysis patients. Mortality is higher on dialysis days and is associated with higher dialysate bicarbonate (DBIC).

Contrary to our hypothesis, there was no consistent association of higher DBIC with a higher risk of arrhythmia.

Further research is needed to assess the optimal DBIC and mechanisms by which it may improve outcomes for maintenance hemodialysis patients.

Background

Sudden death accounts for approximately 25% of deaths among maintenance hemodialysis patients, occurring more frequently on hemodialysis days. Higher dialysate bicarbonate (DBIC) may predispose to alkalemia and arrhythmogenesis.

Methods

We conducted a 12-month analysis of session-level data from 66 patients with implantable loop recorders. We fit logistic regression and negative binomial mixed-effects regression models to assess the association of DBIC with clinically significant arrhythmia (ventricular tachycardia ≥115 beats per minute [BPM] for at least 30 seconds, bradycardia ≤40 BPM for at least 6 seconds, or asystole for at least 3 seconds) and reviewer confirmed arrhythmia (RCA—implantable loop recorder-identified or patient-marked event for which a manual review of the stored electrocardiogram tracing confirmed the presence of atrial fibrillation, supraventricular tachycardia, sinus tachycardia with rate >130 BPM, ventricular tachycardia, asystole, or bradycardia). Models adjusted for age, sex, race, hemodialysis vintage, vascular access, and prehemodialysis serum bicarbonate and additionally for serum and dialysate potassium levels.

Results

The mean age was 56±12 years, 70% were male, 53% were Black, and 35% were Asian. Fewer RCA episodes were associated with DBIC >35 than 35 mEq/L (incidence rate ratio 0.45 [0.27 to 0.75] and adjusted incident rate ratio 0.54 [0.30 to 0.97]), but the association was not significant when adjusting for serum and dialysate potassium levels (adjusted incident rate ratio, 0.60 [0.32 to 1.11]). Otherwise, no associations between DBIC and arrhythmia were identified.

Conclusions

We observed a lower frequency of RCA with higher DBIC, compared with DBIC of 35 mEql/L, contrary to our original hypothesis, but this association was attenuated in fully adjusted models. Validation of these findings in larger studies is required, with a further need for interventional studies to explore the optimal DBIC concentration.
Tamarind Intake and Hypertension: An Alarming Association Found in the Bandar Kong Cohort Study
Authors: Samiei Afshin , Rafati Shide , Nejatizadeh Azim , Khaghanzadeh Narges
Published: August 2024

Background: Hypertension (HTN) is a significant global public health concern and can elevate the risk of cardiovascular and kidney diseases. Tamarind (Tamarindus indica, Fabaceae), a tropical fruit highly valued for its pulp, offers many health benefits, including a reduction in oxidative stress and inflammation. Nonetheless, emerging uncertainties surround Tamarind’s efficacy in certain health aspects. This study examined its potential negative impact on HTN within the Bandar Kong cohort. Materials and Methods: The current study included 2823 participants of the Bandar Kong cohort study, of whom 693 individuals (24.5%) had HTN, with 288 men (25.3%) and 405 women (24.0%) being affected. Binary logistic regression analysis was used to investigate the connections between variables and the likelihood of HTN in both men and women. Moreover, multivariable binary logistic regression analysis and multivariable linear regression were utilized to determine the correlation between Tamarind consumption and the risk of HTN. Results: After adjusting for covariates, the odds of HTN in males with moderate consumption of Tamarind were 0.55 higher than in males with low consumption of Tamarind. Tamarind consumption was significantly associated with the risk of HTN in both genders, with males and females who consumed moderate to high amounts having a higher risk. The findings revealed that high consumption of Tamarind was associated with higher diastolic blood pressure (BP) in females. Conclusion: The study suggests that moderate to high consumption of Tamarind may have a negative impact on HTN among both males and females. Although Tamarind is highly valued for its pulp and offers some health benefits, its potential negative impact on HTN should be taken into consideration.
The Longevity of Long COVID and the Diagnosis-Related Challenges
Authors: Asadi-Pooya Ali A. , Jafari Anahita , Nemati Hamid , Karimi Afrooz , Nasiri Sara , Mohammadi Seyyed Saeed , Nemati Meshkat , Rahimian Zahra , Bayat Hossein , Shahisavandi Mina , Akbari Ali , Emami Amir
Published: August 2024

Background: Long COVID syndrome (LCS) is characterized by chronic symptoms of fatigue, cough, etc. after contracting COVID-19. This study aimed to identify the longevity of the symptoms of adults who reported suffering from LCS in our previous study which was conducted in 2021. The study population included patients who were referred to healthcare facilities (55 centers) in Fars province, Iran. Materials and Methods: This longitudinal retrospective and follow-up cohort study was conducted on adult patients who were hospitalized with COVID-19. We inquired about their current health status and obtained the information after they consented to participate and answer questions over the phone. Results: In total, 2383 people participated in the study, 543 of whom (27.3%) reported experiencing symptoms of LCS. Fatigue (12.2%) and exercise intolerance (10%) were the two most common symptoms of persistent LCS. On the other hand, 240 people (12.1%) who did not report any symptoms of LCS in phase 1 of the study reported experiencing problems that are compatible with the diagnosis of LCS. Patients with persistent LCS (long-LCS) had longer hospital stays during their initial illness (7 days vs. 5 days) and were more frequently admitted to ICUs (15.8% vs. 8.9%) compared with those without long-LCS. Conclusion: More than one-quarter of adults will continue to suffer from the symptoms of long-COVID for more than one year after their initial infection. The scientific community should develop validated measures and biomarkers to objectively diagnose and follow up this condition.
Investigating the Association Between Waterpipe/Cigarette Smoking and Incidence of Musculoskeletal Disorders
Authors: Tajvar Abdolhamid , Ghanbarnejad Amin , Kazempour Marzieh
Published: August 2024

Background: Tobacco smoking is an essential factor that affects people’s quality of life. Numerous studies have suggested that tobacco smoking has considerable harmful effects on the musculoskeletal system. In addition, it has a high prevalence in Hormozgan Province, Iran. Accordingly, this research investigates the consumption of tobacco products and its relationship with the prevalence of symptoms of musculoskeletal disorders in service workers of Bandar Abbas City, Iran. Materials and Methods: This was a descriptive-analytical epidemiological study with cross-sectional data. The population comprised 351 urban service workers employed in Bandar Abbas City, Iran. In the present research, musculoskeletal disorders over the past 12 months were investigated using the Nordic questionnaire in each of the nine body parts. Results: The mean age of the participants was 37.66±7.9 years. More than half of the studied population (52%) smoked tobacco, and all of them experienced more musculoskeletal problems compared to the other group. Musculoskeletal disorders in tobacco smokers showed a significant difference in four parts of the body, including the elbow, lower back, hip, and knees, with P<0.05 when compared to individuals who did not smoke tobacco. Conclusion: Individuals who smoked tobacco experienced higher pain in their muscles and bones compared to the other group, which can arise from the adverse effects of tobacco products on muscles, tendons, cartilage, and ligaments. Hence, suitable policies and plans are required to prevent and reduce tobacco consumption in the province, especially in occupations that are susceptible to musculoskeletal disorders.
Investigating the Microbial Contamination of Unpackaged Cigarettes (Bulk) in Bandar Abbas City, Iran
Authors: Alipour Vali , Dehghani Somayyeh , Rezaei Leila , Jabari Sogand , Qanbaranjad Amin , Soleimani Farshid , Javdan Gholamali , Zakeri Abdoljabbar
Published: August 2024

Background: Cigarette contamination due to contact with contaminated hands is one of the problems of bulk cigarette distribution. This study was conducted to investigate the microbial contamination of unpackaged cigarettes in Bandar Abbas City, Iran. Materials and Methods: This study was conducted among various distributors of bulk cigarettes (peddlers, stalls, and supermarkets) in Bandar Abbas City. Cigarette samples were dried, and the microbial quality of their filter was evaluated by Ultersnap U microbial load measuring device. To express the index of microbial contamination, based on the defined scale of the device, RLUs (relative light units) ≤10 indicate cleanliness, 11 to 29 denote the warning level, and ≥30 signify contamination. Results: Our results showed that 26.9% of cigarettes were sold by vendors, 65.4% by stalls, and 7.7% by supermarkets. The prevalence rates of microbial contamination in standard packaged and unpackaged (bulk) cigarettes were 2.3% and 46.2%, respectively. Among the examined samples, 17.3% were clean, 36.5% were contaminated at the warning level, and 46.2% were contaminated. The percentages of contaminated cigarettes sold by vendors, stalls, and supermarkets were 50%, 47.1%, and 25%, respectively. Conclusion: The results of this study underscore microbial contamination as another side risk that can be transferred directly from the hands of the supplier to the mouth of the consumer. The intensity of contamination was different based on the place of supply (sales units). Therefore, more attention should be paid to the organization of distribution units of these products.
Green municipal bonds in the energy transition process
Authors: Marszałek Jakub , Sekuła Paweł
Published: August 2024

In this article, we focus on green bonds issued by local authorities for the energy transition of cities. Using bonds listed on public markets, we compared the yields of municipal energy bonds with those of other bonds of the same issuer at the same time. The comparison was made using the Wilcoxon signed-rank test. The study aimed to establish the presence of greenium, which can significantly reduce the cost of financing green energy projects implemented by urban centres. The study included selected agglomerations from almost every continent with different financial market experiences. The results indicate a wide variation in the occurrence of greenium, both in terms of value and stableness over time. This may imply that other non-financial factors influence its properties. However, the study results show the potential for reducing the cost of financing energy transition implemented by cities and may have practical relevance.
Role of sodium and potassium in the diet of school-aged children in Ireland: Findings from the National Children’s Food Survey II
Authors:   ,   Cork Institute of Technology, Morrissey Eoin
Published: August 2024

A high sodium to potassium intake ratio (Na:K) resulting from a diet high in sodium and low in potassium can increase the risk of elevated blood pressure or hypertension in children, potentially leading to increased CVD in adulthood. The objective of this thesis was to estimate sodium and potassium intakes and Na:K in school-aged children (5-12y) in Ireland using data from the nationally representative National Children’s Food Survey II (NCFS II) (2017-18). The thesis study collected detailed dietary intake data for 600 children using 4-d food records and also collected spot urine samples from 95% of these participants. Sodium and potassium intakes and Na:K were estimated from the spot urines based on urinary excretion of sodium and potassium measured with a Randox RX Daytona. Dietary intakes and key sources of sodium and potassium were also estimated and compared with previous data collected in the NCFS (2003-04). Foods which determined a lower Na:K were identified. The key findings of this study were that the mean sodium intake of Irish children generally exceeded recommendations, while mean potassium intakes below recommendations were found for older children aged 11- 12 years. The key sources of sodium were processed meats and breads, while the key sources of potassium were meats, milks, potatoes and fruit & fruit juices. Children with a lower Na:K had higher intakes of breakfast cereals, milk & yogurt, potatoes, vegetables & vegetable dishes, fruit & fruit juices and fresh meat and lower intakes of savoury foods, breads, cheese, processed meats and soft drinks. Compliance with the WHO optimal target urinary Na:K ≤1.0mmol/mmol was very low at 19%. Strategies to lower Na:K amongst Irish children may reduce the proportion of children at risk of developing hypertension and indirectly reduce the prevalence of hypertension related diseases amongst Irish adults.
ПІДГОТОВКА ВИКЛАДАЧІВ ЗАКЛАДІВ ВИЩОЇ ОСВІТИ ДО ЗАСТОСУВАННЯ ІННОВАЦІЙНИХ ТЕХНОЛОГІЙ НАВЧАННЯ: ТЕОРЕТИКО-КОНЦЕПТУАЛЬНИЙ АСПЕКТ
Authors: Попова Олена
Published: August 2024

Автором обґрунтовано актуальність проблеми підготовки викладачів закладів вищої освіти до застосування інноваційних технологій навчання, що зумовлено сучасними викликами, які постають перед вищою освітою, котрі наочно відображають стратегії підвищення якості освітнього процесу в закладах вищої освіті, найбільш перспективними з яких є інноваційні. Інноваційну технологію навчання розглянуто як системний феномен, який внаслідок упорядкованого їх здійснення педагогом за оптимальності ресурсів і зусиль усіх учасників педагогічного процесу, гарантовано забезпечує ефективну реалізацію прогнозованого результату, спрямованого на особистісний і професійний розвиток і саморозвиток здобувача освіти на основі сучасних методологічних підходів до організації процесу навчання з урахуванням теоретичних та емпіричних інновацій, що в змозі забезпечити високі результати професійного навчання. Доведено, що ефективність застосування інноваційних технологій навчання значною мірою залежить від рівня відповідної готовності викладачів, що вимагає організації їхньої цілеспрямованої і систематичної підготовки в означеному напрямі. Готовність викладача до застосування інноваційних технологій навчання визначено як динамічне інтегроване особистісне утворення, що включає професійні мотиви, цілі, спеціальні (інноваційні) знання й уміння, професійно-особистісні якості викладача, що забезпечують ефективне впровадження вказаних технологій у процес навчання здобувачів вищої освіти. У статті акцентовано увагу на необхідності переосмислення філософських засад підготовки викладачів до використання інноваційних технологій навчання, відповідно до вимог часу, а також урахування в процесі зазначеної підготовки положень таких концептуальних підходів, як-от: компетентісного, системного, особистісно-діяльнісного, інноваційного, акмеологічного, андрагогічного. У статті обґрунтовано суть і значення цих підходів для розв’язання порушеної проблеми.
Ключові слова: інноваційна технологія навчання; професійна підготовка; готовність; викладач; заклад вищої освіти.
Obtención y evaluación preclínica de nanovehículos farmacéuticos con aplicación en el tratamiento de la enfermedad de Chagas
Authors:   , Muraca Giuliana
Published: August 2024

La enfermedad de Chagas es una parasitosis endémica de América Latina. El agente etiológico del Chagas es el parásito Trypanosoma cruzi, un protozoario hemoflagelado cuyo ciclo de vida incluye hospedadores vertebrados (entre ellos, el hombre) e invertebrados (insectos hematófagos triatominos). Existen sólo dos tratamientos farmacológicos utilizados contra la enfermedad: nifurtimox y benznidazol. Ambos presentan serios efectos adversos, siendo las más frecuentes, dermatitis, edema, fiebre, linfoadenopatía, dolor articular y muscular, y otros más severos como púrpura trombocitopénica, agranulocitosis y polineuropatías. El hecho de que las drogas disponibles poseen probados efectos tripanocidas y alta eficacia en la fase aguda, sugiere que la baja eficacia en la fase crónica podría deberse a un problema de biodistribución, esto es, la imposibilidad de las drogas de alcanzar concentraciones efectivas a nivel intracelular, donde se localiza mayormente la forma del parásito predominante en la fase crónica. Por esta razón, numerosos autores han sugerido que vehiculizar los fármacos antichagásicos disponibles en vehículos farmacéuticos de última generación (particularmente, nanovehículos) podrían ser de gran utilidad para aumentar los niveles de fármaco a nivel tisular, mejorando la dosificación, el perfil de seguridad, la eficacia y la adherencia al tratamiento. El objetivo de esta tesis fue desarrollar nanovehículos farmacéuticos como alternativas terapéuticas superadoras para el tratamiento de la enfermedad de Chagas, optimizando la biodistribución, eficacia y seguridad de los fármacos antichagásicos actualmente disponibles. Se obtuvieron nanopartículas lipídicas y poliméricas a las que se les realizó una exhaustiva caracterización fisicoquímica, evaluación in vitro e in vivo en un modelo murino de infección aguda. Si bien la eficacia de las formulaciones no fue superadora al fármaco libre en el modelo de ratón, se encontró una actividad tripanocida de uno de los componentes de las nanopartículas lipídicas que podría resultar en un sinergismo con los fármacos que se utilizan para el tratamiento de la enfermedad de Chagas.
Analisis Komunikasi Kebijakan Publik Pusat Kajian dan Perlindungan Anak dalam Pencegahan Tindak Kejahatan pada Anak di Kota Medan
Authors: Endrayani Deni , Harahap Nursapia , Ritonga Elvi Yanti
Published: August 2024

Penelitian ini fokus pada analisis komunikasi kebijakan yang diimplementasikan oleh Pusat Kajian dan Perlindungan Anak (PKPA) di Medan dalam upaya pencegahan kejahatan terhadap anak. Data menunjukkan peningkatan signifikan dalam kasus kekerasan fisik dan seksual terhadap anak di Indonesia, dengan kejahatan seksual mendominasi sebagian besar insiden. Sebagai respons terhadap situasi darurat ini, pemerintah Indonesia telah mengeluarkan undang-undang yang lebih ketat untuk melindungi anak, namun tantangan masih tetap ada, termasuk persepsi masyarakat yang toleran terhadap kekerasan dan hambatan dalam mengawasi interaksi anak di dunia digital. Studi ini mengkaji bagaimana PKPA Medan menggunakan berbagai platform media untuk menyebarkan informasi dan mengedukasi publik tentang pentingnya melindungi anak-anak dari kekerasan dan eksploitasi. Penelitian ini bertujuan untuk memahami efektivitas strategi komunikasi yang digunakan PKPA dan memberikan rekomendasi bagi lembaga serupa dalam menyusun dan mengimplementasikan kebijakan komunikasi yang efektif. Metode yang digunakan meliputi analisis konten dari kampanye komunikasi PKPA dan wawancara dengan stakeholder utama. Hasil penelitian diharapkan dapat meningkatkan kesadaran dan respons terhadap perlindungan anak, serta menginformasikan pembentukan kebijakan dan praktik terbaik dalam pencegahan kejahatan pada anak di Indonesia.
ANALISIS HUKUM JUSTICE COLLABORATOR TERHADAP PUTUSAN TINDAK PIDANA KORUPSI DI PENGADILAN NEGERI MAKASSAR
Authors: Mustafa Muchlis , Madiong Baso , Hasan Yulia A.
Published: August 2024

Penelitian ini bertujuan untuk menganalisis pertimbangan hakim dalam permohonan Justice colaborator dalam tindak pidana korupsi pada Pengadilan Negeri Makassar dan faktor penilaian hakim dalam permohonan Justice Collaborator dalam Perkara Tindak Pidana Korupsi. Metode penelitian yang digunakan adalah penelitian normatif empiris dengan pendekatan kualitatif yang dilakukan di pengadilan negeri makassar terhadap terdakwa tindak pidana korupsi, advokat yang menangani tindak pidana korupsi, metode yang digunakan wawancara langsung dan study kepustakaan. Hasil penelitian menunjukkan bahwa pertimbangan hakim menolak Justice Colaborator terhadap terdakwa karena terdakwa adalah pelaku utama yang sudah memenuhi unsur unsur mengenai adanya keterlibatan. Pihak lain yang disebutkan terdakwa dalam permohonannya baru sebatas keterangan dan belum didukung oleh alat bukti lainnya sesuai ketentuan hukun yang berlaku sehingga hakim memberi pertimbangan menolak justice kolaborator terdakwa karena berpedoman pada SEMA No. 4 Tahun 2011. Sedangkan faktor penilaian hakim dalam mengabulkan permohonan Justice colaborator meliputi Keterlibatan dalam Tindak Pidana Korupsi, Relevansi Informasi yang Diberikan, Kesesuaian dengan Tujuan Hukum, Kerjasama yang Jujur dan Penuh Kerelaan, Kecukupan Bukti Tambahan, Keamanan dan Perlindungan Saksi, Ketentuan Hukum dan Kebijakan Negara.
This study aims to analyze the judge's consideration in the application of a justice collaborator in a corruption crime in Makassar District Court and the factors that affect the justice collaborator in a corruption crime can be granted by the panel of judges. The research method used is empirical normative research with a qualitative approach conducted in Makassar District Court on corruption defendants, advocates who handle corruption crimes, methods used direct interviews and literature studies. The results showed that the judge's consideration rejected the collaborator's justice against the defendant because the defendant was the main perpetrator who had fulfilled the elements regarding involvement. The other party mentioned by the defendant in his application is only limited to information and has not been supported by other evidence in accordance with the applicable legal provisions so that the judge gave consideration to reject the defendant's collaborator justice because it was guided by SEMA No.4 of 2011. Meanwhile, the factors assessed by the judge in granting the request for Justice Collaborator include Involvement in Corruption, Relevance of Information Provided, Conformity with Legal Objectives, Honest and Willing Cooperation, Adequacy of Additional Evidence, Security and Witness Protection, Legal Provisions and State Policy.