bluuebunny/crossref_metadata_2025 huggingface dataset:
The Clinical Relevance of the NATALEE Study: Application of the NATALEE Criteria to a Real-World Cohort from Two Large German Breast Cancer Centers
Authors: Schäffler Henning , Mergel Franziska , Pfister Kerstin , Lukac Stephan , Fink Angelina , Veselinovic Kristina , Rack Brigitte , Fink Visnja , Leinert Elena , Dimpfl Moritz , Englisch Alexander , Tegeler Christian Martin , Seller Anna , Grischke Eva-Maria , Hahn Markus , Volmer Léa Louise , Engler Tobias , Frevert Marie Louise , Taran Florin Andrei , Janni Wolfgang , Brucker Sara Yvonne , Hartkopf Andreas Daniel , Dannehl Dominik
Published: November 2023

The NATALEE study showed a significant benefit in invasive disease-free survival (iDFS) for patients with HR+/HER2− early breast cancer (eBC) at intermediate and high risk of recurrence who were treated with the CDK4/6 inhibitor Ribociclib in combination with endocrine therapy (ET). This retrospective study aims to apply the NATALEE inclusion criteria to a representative real-world cohort to estimate the proportion of HR+/HER2− breast cancer patients eligible for adjuvant Ribociclib therapy. Patients who underwent full surgical treatment for eBC between January 2018 and December 2020 at two large German university breast cancer centers (University of Ulm, University of Tuebingen) were included. Descriptive statistics were used to characterize the patient population eligible for Ribociclib treatment based on the NATALEE study’s inclusion criteria. Out of 2384 enrolled patients, 1738 had HR+/HER2− eBC, of whom 43% (747/1738) met the NATALEE inclusion criteria. Of note, these patients were older, received less chemotherapy and presented with less advanced tumor stages compared to the NATALEE study cohort. Additionally, compared to the NATALEE study cohort, fewer patients had lymph node involvement (72.4% vs. 88.7%). Our analysis suggests that approximately 43% of all HR+/HER2− breast cancer patients will qualify for Ribociclib treatment. Given the numerous treatment options for patients with HR+/HER2− eBC, as well as the differences between the NATALEE cohort and patients in the real-world clinical setting, future analyses will be needed to determine which patients would benefit most from adjuvant CDK4/6 inhibitor treatment.
Research Progress on the Relationship between Vitamins and Diabetes: Systematic Review
Authors: Liu Jiameng , Qin Luqi , Zheng Jiahuan , Tong Litao , Lu Wei , Lu Cong , Sun Jing , Fan Bei , Wang Fengzhong
Published: November 2023

Diabetes is a serious chronic metabolic disease that causes complications over time, bringing serious public health challenges that affect different countries across the world. The current clinical drugs for diabetes may lead to adverse effects such as hypoglycemia and liver and abdominal distension and pain, which prompt people to explore new treatments for diabetes without side effects. The research objective of this review article is to systematically review studies on vitamins and diabetes and to explain their possible mechanism of action, as well as to assess the role of vitamins as drugs for the prevention and treatment of diabetes. To achieve our objective, we searched scientific databases in PubMed Central, Medline databases and Web of Science for articles, using “vitamin” and “diabetes” as key words. The results of numerous scientific investigations revealed that vitamin levels were decreased in humans and animals with diabetes, and vitamins show promise for the prevention and/or control of diabetes through anti-inflammation, antioxidation and the regulation of lipid metabolism. However, a few studies showed that vitamins had no positive effect on the development of diabetes. Currently, studies on vitamins in the treatment of diabetes are still very limited, and there are no clinical data to clarify the dose–effect relationship between vitamins and diabetes; therefore, vitamins are not recommended as routine drugs for the treatment of diabetes. However, we still emphasize the great potential of vitamins in the prevention and treatment of diabetes, and higher quality studies are needed in the future to reveal the role of vitamins in the development of diabetes.
Development of Novel Epigenetic Anti-Cancer Therapy Targeting TET Proteins
Authors: Kim Hyejin , Jung Inkyung , Lee Chan Hyeong , An Jungeun , Ko Myunggon
Published: November 2023

Epigenetic dysregulation, particularly alterations in DNA methylation and hydroxymethylation, plays a pivotal role in cancer initiation and progression. Ten-eleven translocation (TET) proteins catalyze the successive oxidation of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) and further oxidized methylcytosines in DNA, thereby serving as central modulators of DNA methylation–demethylation dynamics. TET loss of function is causally related to neoplastic transformation across various cell types while its genetic or pharmacological activation exhibits anti-cancer effects, making TET proteins promising targets for epigenetic cancer therapy. Here, we developed a robust cell-based screening system to identify novel TET activators and evaluated their potential as anti-cancer agents. Using a carefully curated library of 4533 compounds provided by the National Cancer Institute, Bethesda, MD, USA, we identified mitoxantrone as a potent TET agonist. Through rigorous validation employing various assays, including immunohistochemistry and dot blot studies, we demonstrated that mitoxantrone significantly elevated 5hmC levels. Notably, this elevation manifested only in wild-type (WT) but not TET-deficient mouse embryonic fibroblasts, primary bone marrow-derived macrophages, and leukemia cell lines. Furthermore, mitoxantrone-induced cell death in leukemia cell lines occurred in a TET-dependent manner, indicating the critical role of TET proteins in mediating its anti-cancer effects. Our findings highlight mitoxantrone’s potential to induce tumor cell death via a novel mechanism involving the restoration of TET activity, paving the way for targeted epigenetic therapies in cancer treatment.
Safety of Retrograde Tibial-Pedal Access and Intervention in Patients with Single Remaining Non-Occluded Infra-Popliteal Runoff Artery
Authors: Siu Henry K. , Schultz Emily , LeBrun Sandrine , Liou Michael , Kwan Tak W.
Published: November 2023

Background: The adaptation of retrograde tibial-pedal access for peripheral angiogram and intervention is limited by the lack of operator experience and concern for small distal vessel injury. This study evaluates the safety of the retrograde tibial-pedal access for peripheral angiogram and intervention in patients with two vessel infra-popliteal artery chronic total occlusions, where the access point is the sole remaining non-occluded infra-popliteal artery. Methods: A retrospective analysis of 5687 consecutive patients who underwent peripheral angiograms by retrograde tibial-pedal access via the single remaining non-occluded infra-popliteal artery was performed. Patients who had retrograde tibial-pedal access at the sole remaining infra-popliteal artery confirmed by angiography were included. Clinical and ultrasound data of the accessed infra-popliteal vessel up to 6 months were collected. Results: The cohort consisted of 314 patients (152 males; mean age 77.9 years). At 6 months, access vessel complications occurred in 15 patients (4.8%). Access vessel occlusion occurred in 9 out of 314 patients (2.9%), arteriovenous fistula in 4 (1.3%), with spontaneous resolution in 2, pseudoaneurysm requiring thrombin injection in 2 (0.6%) and non-cardiovascular death in 1 (0.3%). No uncontrolled bleeding, procedure-related hospitalizations or limb amputations occurred. Conclusions: Routine primary retrograde tibial-pedal access for lower extremity peripheral artery diagnostic angiography and intervention in patients with single infra-popliteal artery runoff can be safety performed in an outpatient setting with infrequent and manageable complications.
Body Mass Index, Quality of Life and Activity Limitation Trajectories over 2 Years in Patients with Knee or Hip Osteoarthritis: A Dual Trajectory Approach Based on 4265 Patients Included in the AktivA Quality Register
Authors: Fosdahl Merete Aarsland , Berg Bjørnar , Risberg May Arna , Øiestad Britt Elin , Holm Inger
Published: November 2023

(1) Background: Recent studies claim that weight-neutral approaches emphasizing physical activity might be as effective as weight-loss-centered approaches for improving pain and physical function in patients with knee and hip osteoarthritis. The objectives were to identify distinctive groups of individuals with similar BMI, quality of life and activity limitation trajectories over two years, to compare the overall differences between BMI trajectory groups for baseline variables and to explore the probabilities of the quality of life and activity limitation trajectory groups conditional on the BMI group. (2) Methods: Baseline data for age, gender, BMI, quality of life, activity limitations, pain, general health, knee or hip osteoarthritis and follow-up data on BMI, quality of life and activity limitations at 3, 12 and 24 months were retrieved from the “Active with osteoarthritis” (AktivA) electronic quality register. Group-based trajectory modeling was used to identify distinct trajectories for BMI, quality of life and activity limitations. (3) Results: 4265 patients were included in the study. Four distinct BMI trajectories were identified, normal weight (31%), slightly overweight (43%), overweight (20%) and obese (6%). At baseline, there were highly significant differences between all BMI groups, pain increased and age and general health decreased with higher BMI. Irrespective of weight category, minimal changes in BMI were found over the two-year follow-up period. Over 80% of the participants showed moderate-to-considerable improvements both in quality of life and activity limitations. (4) Conclusions: Almost 70% of the participants belonged to the overweight trajectories. Despite no significant weight reduction over the two years, eight in every 10 participants improved their quality of life and reduced their activity limitations after participating in the AktivA program.
Minimally Invasive Strategy to Repair Mitral Valve after Repeated Coronary Revascularization: A Case Report and Literature Review
Authors: Asta Laura , Benedetto Umberto , Tancredi Fabrizio Costantino , Di Giammarco Gabriele
Published: November 2023

Redo cardiac surgery after Coronary Artery Bypass Grafting (CABG) is burdened by high morbidity and mortality, either intraoperatively and postoperatively, with the repeated sternotomy playing a crucial role as risk factor. The right minithoracotomy approach guarantees a safer control on conduits integrity and the right ventricular wall and a low impact on the respiratory mechanics. Herein, we report a patient who previously underwent two CABG (coronary artery bypass grafting) procedures and who was admitted to the hospital with a picture of heart failure caused by a severe mitral regurgitation. He was successfully submitted to a mitral valve repair on a beating heart via the right minithoracotomy approach.
Discrepancies between Retrospective Review of “Real-Time” Electronic Health Record Documentation and Prospective Observer Documentation of In-Hospital Cardiac Arrest Quality Metrics in an Academic Cardiac Intensive Care Unit
Authors: Morris Nicholas A. , Couperus Cody , Jasani Gregory , Day Lauren , Stultz Christa , Tran Quincy K.
Published: November 2023

Background: Every year, approximately 200,000 patients will experience in-hospital cardiac arrest (IHCA) in the United States. Survival has been shown to be greatest with the prompt initiation of CPR and early interventions, leading to the development of time-based quality measures. It is uncertain how documentation practices affect reports of compliance with time-based quality measures in IHCA. Methods: A retrospective review of all cases of IHCA that occurred in the Cardiac Intensive Care Unit (CICU) at an academic quaternary hospital was conducted. For each case, a member of the code team (observer) documented performance measures as part of a prospective cardiac arrest quality improvement database. We compared those data to those abstracted in the retrospective review of “real-time” documentation in a Resuscitation Narrator module within electronic health records (EHRs) to investigate for discrepancies. Results: We identified 52 cases of IHCA, all of which were witnessed events. In total, 47 (90%) cases were reviewed by observers as receiving epinephrine within 5 min, but only 42 (81%) were documented as such in the EHR review (p = 0.04), meaning that the interrater agreement for this metric was low (Kappa = 0.27, 95% CI 0.16–0.36). Four (27%) eligible patients were reported as having defibrillation within 2 min by observers, compared to five (33%) reported by the EHR review (p = 0.90), and with substantial agreement (Kappa = 0.73, 95% CI 0.66–0.79). There was almost perfect agreement (Kappa = 0.82, 95% CI 0.76–0.88) for the initial rhythm of cardiac arrest (25% shockable rhythm by observers vs. 29% for EHR review, p = 0.31). Conclusion: There was a discrepancy between prospective observers’ documentation of meeting quality standards and that of the retrospective review of “real-time” EHR documentation. A further study is required to understand the cause of discrepancy and its consequences.
Cardiac Computed Tomography in Monitoring Revascularization
Authors: Tonet Elisabetta , Amantea Veronica , Lapolla Davide , Assabbi Paolo , Boccadoro Alberto , Berloni Maria Letizia , Micillo Marco , Marchini Federico , Chiarello Serena , Cossu Alberto , Campo Gianluca
Published: November 2023

The use of coronary computed tomography angiography (CCTA) in the setting of stable coronary artery disease is highly recommended for low-risk patients. High-risk patients, such as symptomatic subjects with prior revascularization, are suggested to be investigated with noninvasive functional tests or invasive coronary angiography. CCTA is not considered for these patients because of some well-known CCTA artifacts, such as blooming and motion artifacts. However, new technology has allowed us to obtain images with high spatial resolution, overcoming these well-known limitations of CCTA. Furthermore, the introduction of CT-derived fractional flow reserve and stress CT perfusion has made CCTA a comprehensive examination, including anatomical and functional assessments of coronary plaques. Additionally, CCTA allows for plaque characterization, which has become a cornerstone for the optimization of medical therapy, which is not possible with functional tests. Recent evidence has suggested that CCTA could be used with the aim of monitoring revascularization, both after coronary bypass grafts and percutaneous coronary intervention. With this background information, CCTA can also be considered the exam of choice in subjects with a history of revascularization. The availability of a noninvasive anatomic test for patients with previous coronary revascularization and its possible association with functional assessments in a single exam could play a key role in the follow-up management of these subjects, especially considering the rate of false-positive and negative results of noninvasive functional tests. The present review summarizes the main evidence about CCTA and coronary artery bypass grafts, complex percutaneous coronary intervention, and bioresorbable stent implantation.
Exercise Therapy for Chronic Neck Pain: Tailoring Person-Centred Approaches within Contemporary Management
Authors: de Zoete Rutger M. J.
Published: November 2023

Exercise therapy is considered the best evidence-based approach for managing chronic neck pain. However, the implementation of exercise therapy presents several challenges. Systematic reviews indicate that it has modest effectiveness, while clinical practice guidelines offer limited guidance on the exercise parameters required to optimise clinical outcomes. Moreover, recommendations often fail to differentiate between different types of neck pain. This article addresses the challenges associated with the prescription of exercise for chronic neck pain and provides recommendations for exercise therapy specific to chronic nociceptive, neuropathic, and nociplastic neck pain. The goal of this article is to facilitate the implementation of high-value evidence-based exercise therapy for these distinct types of chronic neck pain with the aim to improve its outcomes and to reduce the related individual and societal burdens.
Epidemiological Situation of High-Prevalence Non-Communicable Diseases in Spain: A Systematic Review
Authors: Aparicio-Rodríguez Yessineth D. , Alonso-Morillejo Enrique , García-Torrecillas Juan Manuel
Published: November 2023

High-prevalence non-communicable diseases (HNCDs) are an ongoing global public health problem, posing a risk to the continuity of the 2030 Agenda for Sustainable Development. The aim of this study is to describe the current situation in Spain regarding certain HNCDs, namely, ischaemic heart disease, type 2 diabetes mellitus and colorectal cancer, including their prevalence and incidence in recent years. A systematic review was conducted between October 2022 and February 2023 using the MEDLINE, ProQuest and Scopus databases. After an exhaustive search, a total of thirty-four articles were included, comprising fourteen articles on colorectal cancer, seven on ischaemic heart disease and thirteen on diabetes mellitus type 2. The main topics included risk factors, lifestyles, mortality and incidence, the importance of screening and patient empowerment. On analysing each disease, it can be gleaned that risk factors and lifestyle impact the incidence, prevalence and mortality of the diseases studied. In addition, responsible human behaviour, associated with lifestyle factors, is related to the occurrence of these three diseases.
Catheter Ablation for Tachyarrhythmias in Left Ventricular Assist Device Recipients: Clinical Significance and Technical Tips
Authors: Kataoka Naoya , Imamura Teruhiko
Published: November 2023

The demand for durable left ventricular assist devices (LVADs) has been increasing worldwide in tandem with the rising population of advanced heart failure patients. Especially in cases of destination therapy, instead of bridges to transplantation, LVADs require a lifelong commitment. With the increase in follow-up periods after implantation and given the lack of donor hearts, the need for managing concomitant tachyarrhythmias has arisen. Atrial and ventricular arrhythmias are documented in approximately 20% to 50% of LVAD recipients during long-term device support, according to previous registries. Atrial arrhythmias, primarily atrial fibrillation, generally exhibit good hemodynamic tolerance; therefore, catheter ablation cannot be easily recommended due to the risk of a residual iatrogenic atrial septal defect that may lead to a right-to-left shunt under durable LVAD supports. The clinical impacts of ventricular arrhythmias, mainly ventricular tachycardia, may vary depending on the time periods following the index implantation. Early occurrence after the operation affects the hospitalization period and mortality; however, the late onset of ventricular tachycardia causes varying prognostic impacts on a case-by-case basis. In cases of hemodynamic instability, catheter ablation utilizing a trans-septal approach is necessary to stabilize hemodynamics. Nonetheless, in some cases originating from the intramural region or the epicardium, procedural failure may occur with the endocardial ablation. Specialized complications associated with the state of LVAD support should be carefully considered when conducting procedures. In LVAD patients, electrophysiologists, circulatory support specialists, and surgeons should collaborate as an integrated team to address the multifaceted issues related to arrhythmia management.
Advancements in Treatment Strategies for Chronic Mesenteric Ischemia: A Comprehensive Review
Authors: Xhepa Genti , Vanzulli Andrea , Sciacqua Lucilla Violetta , Inzerillo Agostino , Faerber Pierre , Ierardi Anna Maria , Carrafiello Gianpaolo , Del Grande Filippo , Ricoeur Alexis
Published: November 2023

Chronic mesenteric ischemia (CMI) arises from the inability to achieve adequate intestinal blood flow after meals, leading to an imbalance between oxygen and metabolite supply and demand. The true incidence of CMI remains uncertain. However, the occurrence of mesenteric artery occlusive disease (MAOD) is relatively common among the elderly population. Delays in diagnosing CMI can often be attributed to several factors, including the variability in patient symptoms and the range of potential causes for chronic abdominal pain with weight loss. Mikkelson pioneered the introduction of a surgical treatment for occlusive lesions of the superior mesenteric artery (SMA) in 1957. The inaugural performance of endovascular revascularization (ER) for visceral vessels took place in 1980. The literature has documented two types of endovascular revascularization (ER) methods: percutaneous transluminal angioplasty (PTA) and primary stenting (PMAS). Despite the limited quality of available evidence, the consensus among experts is strongly in favor of PMAS over PTA alone for the treatment of atherosclerotic mesenteric artery stenosis. There are several key areas of focus for chronic mesenteric ischemia (CMI) treatment. Randomized controlled trials comparing different stent types, such as covered stents versus bare metal stents, are needed to evaluate efficacy, patency rates, and long-term outcomes in CMI patients.
Cognitive Profile Discrepancies among Typical University Students and Those with Dyslexia and Mixed-Type Learning Disorder
Authors: Scorza Maristella , Gontkovsky Samuel T. , Puddu Marta , Ciaramidaro Angela , Termine Cristiano , Simeoni Loriana , Mauro Marcella , Benassi Erika
Published: November 2023

Background: Previous studies have identified areas of cognitive weakness in children diagnosed with Specific Learning Disorder (SLD), in the areas of working memory and processing speed in particular. In adulthood, this literature is still scant, and no studies have compared the cognitive profile of university students with dyslexia (DD) with that of students with Mixed-type SLD. Method: Thus, in this study, the WAIS-IV was used to examine the cognitive functioning of three groups of university students: students with DD, with Mixed-type SLD, and typical students. Statistical analyses were performed to examine differences in WAIS-IV FSIQ, main, and additional indexes and subtests. Results: The results showed strengths in perceptual reasoning and good verbal comprehension abilities in both the DD and Mixed-type SLD group, with weaknesses in working memory and processing speed, leading to a pattern of a better General Ability Index (GAI) than Cognitive Proficiency Index (CPI) in both clinical groups. Thus, discrepancies between GAI and CPI, well documented in children with SLD, still manifest in adulthood in university students. Our findings also revealed worse cognitive performance in university students with mixed learning disorder relative to students with only a reading deficit. Conclusions: The cognitive features and distinctive subtest profiles that emerged should guide the assessment and the definitions of intervention programs, special educational needs, and strategies of compensation.
The Utility and Appropriateness of Single-Position Circumferential Lumbar Interbody Fusion Using O-Arm-Based Navigation in the Novel Oblique Position
Authors: Ohba Tetsuro , Oda Kotaro , Tanaka Nobuki , Haro Hirotaka
Published: November 2023

Purpose: Single-position surgery with patients in a lateral position, which involves inserting percutaneous pedicular screws (PPS) and lateral interbody fusion (LIF) to avoid changing the position, has been reported. The purpose of the present study was to evaluate the utility and appropriateness of single-position LIF-PPS using O-arm-based navigation in the innovative oblique position. Methods: This study involved a retrospective analysis of 92 consecutive patients with lumbar spondylolisthesis who underwent LIF-PPS using O-arm-based navigation. Thirty-five subjects demonstrated surgery with repositioning, as well as 24 in the lateral decubitus position, and 33 in the oblique during PPS, where the position was changed to the lateral decubitus position using bed rotation without resetting. We compared these three groups in terms of the surgery time, blood loss, and the accuracy of the screw placement. Results: The operative time was significantly shorter in the single-position surgery, both in the lateral and oblique positions, compared to surgery in a dual position. The blood loss was significantly increased in the lateral position compared to the dual and oblique positions. The screw trajectory angle on the downside was significantly smaller in the lateral position, and the accuracy of the screw placement on the downside was significantly lower in the lateral position compared to the dual and oblique positions. Conclusion: Single-position surgery could reduce the average surgery time by about 60 min. The present study indicated the oblique position during PPS insertion might make single-position surgery more useful to improve the accuracy of PPS on the downside, with less blood loss.
Advancements in Conductive Cotton Thread-Based Graphene: A New Generation of Flexible, Lightweight, and Cost-Effective Electronic Applications
Authors: Alhashmi Alamer Fahad , Almalki Ghadah A. , Althagafy Khalid
Published: November 2023

Conductive threads have emerged as a highly promising platform for the advancement of smart textiles, enabling the integration of conductivity into fabric materials. In this study, we present a novel approach to fabricate highly flexible graphene-based smart threads, which exhibit exceptional electrical properties. Four distinct types of smart threads were meticulously prepared by drop-casting graphene dispersions onto cotton threads, utilizing various solvents. The influence of annealing temperature and the quantity of dispersed graphene on the electrical conductivity of the threads was systematically investigated. Our findings reveal that the electrical conductivity of the threads is significantly influenced by the type of solvent and the annealing temperature, while exhibiting an increasing trend with higher amounts of dispersed graphene. Remarkably, we achieved a maximum electrical conductivity of 2505.68 S cm−1 for a thread prepared with 6 mL of graphene dispersed in ethanol, annealed at a temperature of 78 °C. Furthermore, the fabricated smart threads were successfully employed as replacements for electric cables in a mobile charger and a computer mouse, demonstrating their high efficiency. This work represents a significant advancement in the development of a new generation of smart textiles, offering a simple, cost-effective, and environmentally friendly fabrication method for the production of smart threads.
Explainable Connectionist-Temporal-Classification-Based Scene Text Recognition
Authors: Buoy Rina , Iwamura Masakazu , Srun Sovila , Kise Koichi
Published: November 2023

Connectionist temporal classification (CTC) is a favored decoder in scene text recognition (STR) for its simplicity and efficiency. However, most CTC-based methods utilize one-dimensional (1D) vector sequences, usually derived from a recurrent neural network (RNN) encoder. This results in the absence of explainable 2D spatial relationship between the predicted characters and corresponding image regions, essential for model explainability. On the other hand, 2D attention-based methods enhance recognition accuracy and offer character location information via cross-attention mechanisms, linking predictions to image regions. However, these methods are more computationally intensive, compared with the 1D CTC-based methods. To achieve both low latency and model explainability via character localization using a 1D CTC decoder, we propose a marginalization-based method that processes 2D feature maps and predicts a sequence of 2D joint probability distributions over the height and class dimensions. Based on the proposed method, we newly introduce an association map that aids in character localization and model prediction explanation. This map parallels the role of a cross-attention map, as seen in computationally-intensive attention-based architectures. With the proposed method, we consider a ViT-CTC STR architecture that uses a 1D CTC decoder and a pretrained vision Transformer (ViT) as a 2D feature extractor. Our ViT-CTC models were trained on synthetic data and fine-tuned on real labeled sets. These models outperform the recent state-of-the-art (SOTA) CTC-based methods on benchmarks in terms of recognition accuracy. Compared with the baseline Transformer-decoder-based models, our ViT-CTC models offer a speed boost up to 12 times regardless of the backbone, with a maximum 3.1% reduction in total word recognition accuracy. In addition, both qualitative and quantitative assessments of character locations estimated from the association map align closely with those from the cross-attention map and ground-truth character-level bounding boxes.
First Documentation of Large Submarine Sinkholes on the Ganquan Carbonate Platform in the Xisha Islands, South China Sea
Authors: Du Wenbo , Yang Chupeng , Zhang Huodai , Gao Jinwei , Wen Mingming , Hu Xiaosan , Xu Ziying , Nie Xin , Zhu Rongwei
Published: November 2023

Submarine sinkholes are unique and important geomorphological features with a typical cavity structure that are of great scientific value. Submarine sinkholes were discovered for the first time in the isolated Ganquan carbonate platform on the Xisha Islands, the northwestern South China Sea. Based on high-resolution multibeam bathymetric data and seismic profile data, we identified 37 submarine sinkholes at water depths ranging from 550 to 1267 m. They are subcircular to circular negative-relief features, and most of them are V- or compound V-shaped in the cross-section. Their average diameters range from 57 to 667 m, and the depth of the depression ranges from 2.5 to 241 m. By comparing submarine sinkholes in the Ganquan platform with those in other carbonate platforms worldwide, we can infer that the Ganquan platform submarine sinkholes are the largest sinkholes developed on an isolated carbonate platform. Remotely operated vehicle (ROV) “Haima 2” images revealed that the inner walls of submarine sinkholes are characterized by stalactite-like structures, possible dikes, flow marks, and corroded holes, which are typical karstic landscape features. The temperature within submarine sinkholes is 2 °C higher than that of the open ocean at the same water depth. Based on the results of the shallow formation profile and multichannel seismic profiles, we propose that the submarine sinkholes in the Ganquan platform probably formed via the dissolution of the carbonate platform via acidic hydrothermal fluids that originated from magmatic activity and migrated along faults.
Exploring Autonomous and Remotely Operated Vehicles in Offshore Structure Inspections
Authors: Fun Sang Cepeda Maricruz , Freitas Machado Marcos de Souza , Sousa Barbosa Fabrício Hudson , Santana Souza Moreira Douglas , Legaz Almansa Maria José , Lourenço de Souza Marcelo Igor , Caprace Jean-David
Published: November 2023

Operators of offshore production units (OPUs) employ risk-based assessment (RBA) techniques in order to minimise inspection expenses while maintaining risks at an acceptable level. However, when human divers and workers are involved in inspections conducted at high heights, the operational risks can be significant. Recently, there has been a growing trend towards the use of unmanned aerial vehicles (UAVs), autonomous surface vehicles (ASVs), remotely operated vehicles (ROVs), and autonomous underwater vehicles (AUVs) for inspections of offshore structures as a means to reduce exposure to human risk. This article provides an analysis of these vehicle inspection capabilities and their potential to enhance robustness and safety within the oil and gas industry. The review assesses both the advantages and the drawbacks associated with these innovative systems, providing valuable comparisons and assessments on their potential use as viable alternatives to conventional inspection methods.
Risk Level Assessment of Typhoon Hazard Based on Loss Utility
Authors: Liu Guilin , Yang Bokai , Nong Xiuxiu , Kou Yi , Wu Fang , Zhao Daniel , Yu Pubing
Published: November 2023

In the context of climate change with frequent natural disasters, disaster risk assessment can provide great help for related risk decision-making. Based on the theory of loss expectation, this paper presents a quantitative method to assess typhoon disaster risk. Among them, the probability of typhoon occurrence is calculated by fitting the optimal structure function of the sample to the joint distribution of wave height, water increment and wind speed. Then, the loss expectation is expressed as the product of typhoon occurrence probability and loss utility, which is used to quantify the loss result of a typhoon disaster. Using the loss utility theory, the risk grade chart is drawn with the direct economic loss rate and the proportion of the affected population as indicators. The results show that the absolute loss value considering the loss utility is slightly higher than the loss value of the quantitative algorithm by 2% to 25%, indicating that the new model reflects the social group’s aversion to typhoon disaster risk. As can be seen from the risk level zoning map, the highest combined risk level typhoons are Prapiroon 0606 and Chanthu 1003, with a risk level of Category 5. The typhoon comprehensive risk level before 2011 was ≥3, and the typhoon comprehensive risk level from 2012 to 2015 was ≤3. The evaluation model has certain feasibility and practicability, and the results can provide a basis and reference for typhoon risk assessment and decision-making.
An Evaluation of the OLM PneumID Real-Time Polymerase Chain Reaction to Aid in the Diagnosis of Pneumocystis Pneumonia
Authors: Price Jessica S. , Fallon Melissa , Posso Raquel , Backx Matthijs , White P. Lewis
Published: November 2023

Background: The use of the PCR to aid in the diagnosis of Pneumocystis pneumonia (PcP) has demonstrated excellent clinical performance, as evidenced through various systematic reviews and meta-analyses, yet there are concerns over the interpretation of positive results due to the potential presence of Pneumocystis colonization of the airways. While this can be overcome by applying designated positivity thresholds to PCR testing, the shear number of assays described limits the development of a universal threshold. Commercial assays provide the opportunity to overcome this problem, provided satisfactory performance is determined through large-scale, multi-centre evaluations. Methods: Retrospective case/control and consecutive cohort performance evaluations of the OLM PneumID real-time PCR assay were performed on DNA eluates from a range of samples sent from patients where “in-house” PCR had been performed as part of routine diagnostic testing. The clinical performance of the PneumID assay was determined before including it in a diagnostic algorithm to provide the probability of PcP (dependent on diagnostic evidence). Results: After being used to test 317 patients (32 with PcP), the overall performance of the PneumID assay was found to be excellent (Sensitivity/Specificity: 96.9%/95.1%). False positivity could be removed by applying a threshold specific to sample type (<33.1 cycles for BAL fluid; <37.0 cycles for throat swabs), whereas considering any positive respiratory samples as significant generated 100% sensitivity, making absolute negativity sufficient to exclude PcP. Incorporating the PneumID assay into diagnostic algorithms alongside (1-3)-β-D-Glucan testing provided high probabilities of PcP (up to 85.2%) when both were positive and very low probabilities (<1%) when both were negative. Conclusions: The OLM PneumID qPCR provides a commercial option for the accurate diagnosis of PcP, generating excellent sensitivity and specificity, particularly when testing respiratory specimens. The combination of PcP PCR with serum (1-3)-β-D-Glucan provides excellent clinical utility for diagnosing PcP.
Moonlighting Proteins: Diverse Functions Found in Fungi
Authors: Curtis Nicole J. , Patel Krupa J. , Rizwan Amina , Jeffery Constance J.
Published: November 2023

Moonlighting proteins combine multiple functions in one polypeptide chain. An increasing number of moonlighting proteins are being found in diverse fungal taxa that vary in morphology, life cycle, and ecological niche. In this mini-review we discuss examples of moonlighting proteins in fungi that illustrate their roles in transcription and DNA metabolism, translation and RNA metabolism, protein folding, and regulation of protein function, and their interaction with other cell types and host proteins.
50-Year Urban Expansion Patterns in Shanghai: Analysis Using Impervious Surface Data and Simulation Models
Authors: Gao Chen , Feng Yongjiu , Wang Rong , Lei Zhenkun , Chen Shurui , Tang Xiaoyan , Xi Mengrong
Published: November 2023

Megacities serve as crucial catalysts for national economic and social development, and Shanghai, one of China’s most prominent metropolitan areas, exemplifies this transformative urbanization. To study Shanghai’s urban expansion, we extracted urban land cover data from 1985 to 2020 using impervious area products and simulated urban expansion dynamics from 2021 to 2035 by employing the cellular automata model. Leveraging these data, we analyzed a 50-year period of urban expansion and investigated the drivers, including economic factors, population growth, and transportation infrastructure. Our findings indicate that the size of Shanghai’s urban area in 2035 will be nearly 13 times that of 1985. Over these five decades, Shanghai’s urban centroid shifted from the northeast to the southwest, with early urban expansion concentrated in the northeast and later expansion in the southwest. New urban patches primarily emerged at the edges of the initial urban area. As time progressed, areas with higher urban expansion intensity moved outward from the city center, mirroring the trend of urban expansion hotspots. Landscape indicators also demonstrated a trend of urban patches initially spreading and subsequently clustering. Overall, the development of Shanghai’s metropolitan area exhibits substantial spatiotemporal heterogeneity. By integrating correlation analysis and generalized additive models, we quantified the impact of urban expansion drivers. The results show that economic and population factors had high correlation coefficients (over 0.97) with urban area, and proximity to the city center and road network greatly contributed to urban expansion. Our research amalgamates various theories and methods to analyze the spatiotemporal dynamics of urban expansion in metropolitan areas. This work provides a valuable data foundation to aid policymakers in designing effective metropolitan development policies.
The Acquisition of Copula Alternation Ser/Estar and Adjective in L1 Russian, Spanish Heritage Speakers
Authors: Mañas Navarrete Iban , Guijarro Fuentes Pedro , Bello Viruega Iria
Published: November 2023

Spanish copula choice ser/estar and the semantic and pragmatic distinctions that derive from their alternation in predicate adjective constructions have been discussed in several studies focused on the features of Spanish as a heritage language, usually focusing on the lack of equivalence between English and Spanish. The aim of this study is to determine the competence of a group of heritage speakers of Spanish that were born and raised in Russia in adjective copula selection for ser and estar and to what extent it differs from that of L2 speakers. A group of second-generation heritage Spanish-Russian speakers (n = 29) and a group of L1 Russian learners of Spanish as foreign language (n = 23) performed a translation recognition task in Spanish based on extracts from contemporary Spanish literary works. From a crosslinguistic perspective, a partial correspondence can be established between long forms of the Russian adjective with ser, and short forms of the Russian adjective with estar. Taking this cross-language relationship into account, we considered congruent and non-congruent cross-language scenarios. The results confirm that the heritage speakers outperformed the L2 Spanish speakers. This suggests a possible benefit of earlier exposure and use of Spanish. The facilitative effect of L1 can be traced in the ser-preferred scenarios but it fades away in the estar-preferred contexts for both groups.
Development of Mortars That Use Recycled Aggregates from a Sodium Silicate Process and the Influence of Graphene Oxide as a Nano-Addition
Authors: Ruiz Martinez Jaime D. , Cifuentes Héctor , Rios José D. , Ariza Pilar , Leiva Carlos
Published: November 2023

This research analyses how different cement mortars behave in terms of their physical and mechanical properties. Several components were necessary to make seven mixes of mortars, such as Portland cement, standard sand, and solid waste from a factory of sodium silicate, in addition to graphene oxide. Furthermore, graphene oxide (GO) was selected to reduce the micropores and increase the nanopores in the cement mortar. Hence, some tests were carried out to determine their density, humidity content, water absorption capacity, open void porosity, the alkali–silica reaction, as well as flexural and mechanical strength and acid resistance. Thus, standard-sand-manufactured mortars’ mechanical properties were proved to be slightly better than those manufactured with recycled waste; the mortars with this recycled aggregate presented problems of alkali–silica reaction. In addition, GO (in a ratio GO/cement = 0.0003) performed as a filler, improving the mechanical properties (30%), alkali–silica (80%), and acid resistance
Fresh, Mechanical, and Thermal Properties of Cement Composites Containing Recycled Foam Concrete as Partial Replacement of Cement and Fine Aggregate
Authors: Pizoń Jan
Published: November 2023

The research presented in this article was conducted to evaluate the suitability of recycled foam concrete (RFC) as an ingredient in newly created cement mortars. The basis for an analysis was the assumption that the waste is collected selectively after separation from other waste generated during demolition. The motivation for the research and its main problem is a comparison of the performance of RFC used in various forms. RFC was used in two forms: (1) recycled foam concrete dust (RFCD) as a 25 and 50% replacement of cement, and (2) recycled foam concrete fine aggregate (RFCA) as a 10, 20, and 30% replacement of sand. The basic properties of fresh and hardened mortars were determined: consistency, density, initial setting time, absorbability, compressive strength, thermal conductivity coefficient, and heat capacity. Research is complemented with SEM observations. The properties of fresh mortars and mechanical parameters were decreased with the usage of any dosage of RFC in any form, but the thermal properties were improved. The required superplasticizer amount for proper consistency was raised four times for replacing cement with 50% of RFCD than for 25% of such replacement. The mix density dropped by about 8% and 9% for mortars with the replacement of 50% cement by RFCD and 30% sand by RFCA in comparison to reference mortar. A 30% decrease in initial setting time was observed for cement replacement. In the case of sand replacement, it was the opposite—an increase of 100%. The dry density decreased by about 14% and 11% for mortars with the replacement of 50% cement by RFCD and 30% sand by RFCA in comparison to reference mortar. Absorbability was raised by about two times after replacement with both RFCD and RFCA. Compressive strength after 28 days dropped significantly by 75% and 60%, and the thermal conductivity coefficient decreased by 20% and 50% with 50% RFCD added instead of cement and 30% RFCA replacing sand. It indicates greater efficiency in thermomechanical means from RFCA in comparison to RFCD. This material can be used especially in the production of plaster and masonry mortar. Linear correlations of dry density and thermal conductivity coefficient and the latter and compressive strength were proven as reliable for RFCD replacement of cement and RFCA replacement of sand in mortars with greater w/c ratio.
Effect of Synthesis Factors on Microstructure and Thermoelectric Properties of FeTe2 Prepared by Solid-State Reaction
Authors: Zhang Lang , Qin Bingke , Sun Cheng , Ji Yonghua , Zhao Dan
Published: November 2023

The alloying compound FeTe2 is a semi-metallic material with low thermal conductivity and has the potential to become a thermoelectric material. Single-phase FeTe2 compounds are synthesized using a two-step sintering method, and the effects of the optimal sintering temperature, holding temperature, and holding time on the thermoelectric properties of the alloy compound FeTe2 are investigated. The phase composition, microstructure, and electrical transport properties of the FeTe2 compound are systematically analyzed. The results show that single-phase FeTe2 compounds can be synthesized within the range of a sintering temperature of 823 K and holding time of 10~60 min, and the thermoelectric properties gradually deteriorate with the prolongation of the holding time. Microstructural analysis reveals that the sample of the alloy compound FeTe2 exhibits a three-dimensional network structure with numerous fine pores, which can impede thermal conduction and thus reduce the overall thermal conductivity of the material. When the sintering temperature is 823 K and the holding time is 30 min, the sample achieves the minimum electrical resistivity of 6.9 mΩ·cm. The maximum Seebeck coefficient of 65.48 μV/K is obtained when the sample is held at 823 K for 10 min; and under this condition, the maximum power factor of 59.54 μW/(m·K2) is achieved. In the whole test temperature range of 323~573 K, when the test temperature of the sample is 375 K, the minimum thermal conductivity is 1.46 W/(m·K), and the maximum ZT is 1.57 × 10−2.
Manufacturing of Aluminum Nano-Composites Reinforced with Nano-Copper and High Graphene Ratios Using Hot Pressing Technique
Authors: Yehia Hossam M. , Elmetwally Reham A. H. , Elhabak Abdelhalim M. , El-Kady Omayma A. , Shash Ahmed Yehia
Published: November 2023

In this study, the nano-aluminum powder was reinforced with a hybrid of copper and graphene nanoplatelets (GNPs). The ratios of GNPs were 0 wt%, 0.4 wt%, 0.6 wt%, 1.2 wt% and 1.8 wt%. To avoid the reaction between aluminum and graphene and, consequently, the formation of aluminum carbide, the GNP was first metalized with 5 wt% Ag and then coated with the predetermined 15 wt% Cu by the electroless coating process. In addition, the coating process was performed to improve the poor wettability between metal and ceramic. The Al/(GNPs-Ag)Cu nanocomposites with a high relative density of 99.9% were successfully prepared by the powder hot-pressing techniques. The effects of (GNPs/Ag) and Cu on the microstructure, density, hardness, and compressive strength of the Al-Cu nanocomposite were studied. As a result of agitating the GNPs during the cleaning and silver and Cu-plating, a homogeneous distribution was achieved. Some layers formed nano-tubes. The Al4C3 phase was not detected due to coating GNPs with Cu. The Cu9Al4 intermetallic was formed during the sintering process. The homogeneous dispersion of Cu and different ratios of GNs, good adhesion, and the formation of the new Cu9Al4 intermetallic improved in hardness. The pure aluminum sample recorded 216.2 HV, whereas Al/Cu reinforced with 1.8 GNs recorded 328.42 HV with a 51.9% increment. The compressive stress of graphene samples was improved upon increasing the GNPs contents. The Al-Cu/1.8 GNs sample recorded 266.99 MPa.