bluuebunny/crossref_metadata_2025 huggingface dataset:
Multi-Function Tradeoffs of Land System in Urbanized Areas—A Case Study of Xi’an, China
Authors: Shao Jiaqi , Li Fei
Published: June 2021

Multi-functional trade-offs and synergy research on land systems are hotspots in geography and land science research, and are of great significance for achieving sustainable development of land use and the effective allocation of land resources. Recently, the development of the western region and The Belt and Road Initiative have become key topics, bringing opportunities and challenges to Xi’an. The rapid development of cities is accompanied by drastic changes in land use, and the ecological problems in the Qinling Mountains are becoming increasingly severe. This study took Xi’an as a case study and quantitatively evaluated the spatial-temporal patterns and trade-offs of land system functions such as economic development (ED), grain production (GP), ecological service (ES), etc. on the scale of 1 km × 1 km by fusing the data on land use, topography, soil, climate, and social economy. The results showed that the ED function of the land system continued to rise between 1980 and 2015, the GP function first declined and then increased; however, the ES function continued to decline. The ED, GP and ES functions respectively present a spatial pattern of high-value agglomeration, high in the north and low in the south, and high in the south and low in the north. In general, the three land system functions were trade-offs between each other. In terms of spatial pattern, ED and ES functions showed trade-offs in the south and a synergy distribution in the north; ESs and GP function trade-off zone significantly larger than the synergy zone, the trade-off between the two was significant; while the trade-off and the synergy zone for GP and ED was relatively small, the trade-off zone was the main one. The significant trade-off between GP and ES functions of the land system is a serious problem in land use in Xi’an. Under the premise of limited arable land, it is the current feasible strategy to promote the high-quality development of agriculture to increase the cultivation rate and efficiency, and to strengthen the ecological protection of arable land. In addition, the continued decline of ES functions is also worthy of attention. It is necessary to focus on increasing the greening rate of the city and strengthening the ecological management of the northern foot of the Qinling Mountains.
4-Amino-2-(p-tolyl)-7H-chromeno[5,6-d]oxazol-7-one
Authors: Vlachou Evangelia-Eirini , Balalas Thomas , Hadjipavlou-Litina Dimitra , Litinas Konstantinos
Published: June 2021

The new 4-amino-2-(p-tolyl)-7H-chromeno[5,6-d]oxazol-7-one was successfully prepared through the Au/TiO2-catalyzed NaBH4 activation and chemoselective reduction of the new 4-nitro-2-(p-tolyl)-7H-chromeno[5,6-d]oxazol-7-one. The latter was synthesized by the one-pot tandem reactions of 6-hydroxy-5,7-dinitrocoumarin with p-tolylmethanol under Au/TiO2 catalysis. The dinitrocoumarin was obtained by the nitration of 6-hydroxycoumarin with cerium ammonium nitrate (CAN). The structure of the synthesized compounds was confirmed by FT-IR, HR-MS, 1H-NMR and 13C-NMR analysis. Preliminary biological tests show low anti-lipid peroxidation activity for the title compound.
Fire Resistance of High-Volume Fly Ash RC Slab Inclusion with Nano-Silica
Authors: Mussa Mohamed H. , Radzi Noor Azim Mohd , Hamid Roszilah , Mutalib Azrul A.
Published: June 2021

The study aims to investigate the fire performance of reinforced concrete (RC) slab fabricated from high volume fly ash inclusion with nano-silica (HVFANS) under ISO 834 load curve. The HVFANS concrete slab with dimensions of 1850 mm × 1700 mm × 200 mm was tested via an electrical furnace under an exposing temperature of 1100 °C for 120 min. The slab behaviour was evaluated in terms of residual compressive strength, temperature distribution along its thickness, spalling, and cracks. The results revealed that the slab was capable of maintaining 62.19% of its original compressive strength at room temperature after exposure to the above temperature. Moreover, the distribution of temperature revealed that the temperature of concrete cover and bottom reinforcement was less than 300 °C with a maximum spalling depth of 11 mm within the temperature range of 680 to 840 °C. Furthermore, the thermal conductivity index (K) of the HVFANS concrete was determined, and results indicated that thermal conductivity equalled 0.35 W/mK which is considered low, as compared with other concretes tested in current and previous studies.
Statistical and Reliability Study on Shear Strength of Recycled Coarse Aggregate Reinforced Concrete Beams
Authors: Ju Hyunjin , Yerzhanov Meirzhan , Serik Alina , Lee Deuckhang , Kim Jong R.
Published: June 2021

The consumption of structural concrete in the construction industry is rapidly growing, and concrete will remain the main construction material for increasing urbanization all over the world in the near future. Meanwhile, construction and demolition waste from concrete structures is also leading to a significant environmental problem. Therefore, a proper sustainable solution is needed to address this environmental concern. One of the solutions can be using recycled coarse aggregates (RCA) in reinforced concrete (RC) structures. Extensive research has been conducted in this area in recent years. However, the usage of RCA concrete in the industry is still limited due to the absence of structural regulations appropriate to the RCA concrete. This study addresses a safety margin of RCA concrete beams in terms of shear capacity which is comparable to natural coarse aggregates (NCA) concrete beams. To this end, a database for reinforced concrete beams made of recycled coarse aggregates with and without shear reinforcement was established, collecting the shear specimens available from various works in the existing literature. The database was used to statistically identify the strength margin between RCA and NCA concrete beams and to calculate its safety margin based on reliability analysis. Moreover, a comparability study of RCA beams was conducted with its control specimens and with a database for conventional RC beams.
Effect of Thermomechanical Treatment on Structure and Functional Fatigue Characteristics of Biodegradable Fe-30Mn-5Si (wt %) Shape Memory Alloy
Authors: Prokoshkin Sergey , Pustov Yury , Zhukova Yulia , Kadirov Pulat , Karavaeva Maria , Prosviryakov Alexey , Dubinskiy Sergey
Published: June 2021

The Fe-Mn-Si shape memory alloys are considered promising materials for the biodegradable bone implant application since their functional properties can be optimized to combine bioresorbability with biomechanical and biochemical compatibility with bone tissue. The present study focuses on the fatigue and corrosion fatigue behavior of the thermomechanically treated Fe-30Mn-5Si (wt %) alloy compared to the conventionally quenched alloy because this important functionality aspect has not been previously studied. Hot-rolled and water-cooled, cold-rolled and annealed, and conventionally quenched alloy samples were characterized by X-ray diffraction, transmission electron microscopy, tensile fatigue testing in air atmosphere, and bending corrosion fatigue testing in Hanks’ solution. It is shown that hot rolling at 800 °C results in the longest fatigue life of the alloy both in air and in Hanks’ solution. This advantage results from the formation of a dynamically recrystallized γ-phase grain structure with a well-developed dislocation substructure. Another important finding is the experimental verification of Young’s modulus anomalous temperature dependence for the studied alloy system, its minimum at a human body temperature, and corresponding improvement of the biomechanical compatibility. The idea was realized by lowering Ms temperature down to the body temperature after hot rolling at 800 °C.
Improvement of Resistive Switching Performance in Sulfur-Doped HfOx-Based RRAM
Authors: Zhang Zhenzhong , Wang Fang , Hu Kai , She Yu , Song Sannian , Song Zhitang , Zhang Kailiang
Published: June 2021

In order to improve the electrical performance of resistive random access memory (RRAM), sulfur (S)-doping technology for HfOx-based RRAM is systematically investigated in this paper. HfOx films with different S-doping contents are achieved by atmospheric pressure chemical vapor deposition (APCVD) under a series of preparation temperatures. The effect of S on crystallinity, surface topography, element composition of HfOx thin films and resistive switching (RS) performance of HfOx-based devices are discussed. Compared with an undoped device, the VSET/VRESET of the S-doped device with optimal S content (~1.66 At.%) is reduced, and the compliance current (Icc) is limited from 1 mA to 100 μA. Moreover, it also has high uniformity of resistance and voltage, stable endurance, good retention characteristics, fast response speed (SET 6.25 μs/RESET 7.50 μs) and low energy consumption (SET 9.08 nJ/RESET 6.72 nJ). Based on X-ray photoelectron spectroscopy (XPS) data and fitting of the high/low resistance state (HRS/LRS) conduction behavior, a switching mechanism is considered to explain the formation and rupture of conductive filaments (CFs) composed of oxygen vacancies in undoped and S-doped HfOx-based devices. Doping by sulfur is proposed to introduce the appropriate concentration oxygen vacancies into HfOx film and suppress the random formation of CFs in HfOx-based device, and thus improve the performance of the TiN/HfOx/ITO device.
Review on Experimental and Theoretical Investigations of Ultra-Short Pulsed Laser Ablation of Metals with Burst Pulses
Authors: Förster Daniel J. , Jäggi Beat , Michalowski Andreas , Neuenschwander Beat
Published: June 2021

Laser processing with ultra-short double pulses has gained attraction since the beginning of the 2000s. In the last decade, pulse bursts consisting of multiple pulses with a delay of several 10 ns and less found their way into the area of micromachining of metals, opening up completely new process regimes and allowing an increase in the structuring rates and surface quality of machined samples. Several physical effects such as shielding or re-deposition of material have led to a new understanding of the related machining strategies and processing regimes. Results of both experimental and numerical investigations are placed into context for different time scales during laser processing. This review is dedicated to the fundamental physical phenomena taking place during burst processing and their respective effects on machining results of metals in the ultra-short pulse regime for delays ranging from several 100 fs to several microseconds. Furthermore, technical applications based on these effects are reviewed.
Multilayer Diamond Coatings Applied to Micro-End-Milling of Cemented Carbide
Authors: Silva Eduardo L. , Pratas Sérgio , Neto Miguel A. , Fernandes Cristina M. , Figueiredo Daniel , Silva Rui F.
Published: June 2021

Cobalt-cemented carbide micro-end mills were coated with diamond grown by chemical vapor deposition (CVD), with the purpose of micro-machining cemented carbides. The diamond coatings were designed with a multilayer architecture, alternating between sub-microcrystalline and nanocrystalline diamond layers. The structure of the coatings was studied by transmission electron microscopy. High adhesion to the chemically pre-treated WC-7Co tool substrates was observed by Rockwell C indentation, with the diamond coatings withstanding a critical load of 1250 N. The coated tools were tested for micro-end-milling of WC-15Co under air-cooling conditions, being able to cut more than 6500 m over a period of 120 min, after which a flank wear of 47.8 μm was attained. The machining performance and wear behavior of the micro-cutters was studied by scanning electron microscopy and energy-dispersive X-ray spectroscopy. Crystallographic analysis through cross-sectional selected area electron diffraction patterns, along with characterization in dark-field and HRTEM modes, provided a possible correlation between interfacial stress relaxation and wear properties of the coatings. Overall, this work demonstrates that high adhesion of diamond coatings can be achieved by proper combination of chemical attack and coating architecture. By preventing catastrophic delamination, multilayer CVD diamond coatings are central towards the enhancement of the wear properties and mechanical robustness of carbide tools used for micro-machining of ultra-hard materials.
The Individual and the Organizational Model of Quantum Decision-Making and Learning: An Introduction and the Application of the Quadruple Loop Learning
Authors: Russ Meir
Published: June 2021

The new Post Accelerating Data and Knowledge Online Society, or ‘Padkos’, requires a new model of decision-making. This introductory paper proposes a model where decision making and learning are a single symbiotic process, incorporating man and machine, as well as the AADD (ánthrōpos, apparatus, decider, doctrina) amalgamated diamond model of individual and organizational decision-making and learning processes. The learning is incorporated by using a newly proposed quadruple loop learning model. This model allows for controlled changes of identity, the process of creating and the sense-making of new mental models, assumptions, and reflections. The model also incorporates the recently proposed model of quantum decision making, where time collapse of the opted past and the anticipated future (explicitly including its time horizon) into the present plays a key role in the process, leveraging decision making and learning by human as well as artificial intelligence (AI) and machine learning (ML) algorithms.
Random Telegraph Noise in 3D NAND Flash Memories
Authors: Spinelli Alessandro S. , Malavena Gerardo , Lacaita Andrea L. , Monzio Compagnoni Christian
Published: June 2021

In this paper, we review the phenomenology of random telegraph noise (RTN) in 3D NAND Flash arrays. The main features of such arrays resulting from their mainstream integration scheme are first discussed, pointing out the relevant role played by the polycrystalline nature of the string silicon channels on current transport. Starting from that, experimental data for RTN in 3D arrays are presented and explained via theoretical and simulation models. The attention is drawn, in particular, to the changes in the RTN dependences on the array working conditions that resulted from the transition from planar to 3D architectures. Such changes are explained by considering the impact of highly-defective grain boundaries on percolative current transport in cell channels in combination with the localized nature of the RTN traps.
Achieving Triply Periodic Minimal Surface Thin-Walled Structures by Micro Laser Powder Bed Fusion Process
Authors: Qu Shuo , Ding Junhao , Song Xu
Published: June 2021

Recently, triply periodic minimal surface (TPMS) lattice structures have been increasingly employed in many applications, such as lightweighting and heat transfer, and they are enabled by the maturation of additive manufacturing technology, i.e., laser powder bed fusion (LPBF). When the shell-based TPMS structure’s thickness decreases, higher porosity and a larger surface-to-volume ratio can be achieved, which results in an improvement in the properties of the lattice structures. Micro LPBF, which combines finer laser beam, smaller powder, and thinner powder layer, is employed in this work to fabricate the thin-walled structures (TWS) of TPMS lattice by stainless steel 316 L (SS316L). Utilizing this system, the optimal parameters for printing TPMS-TWS are explored in terms of densification, smoothness, limitation of thickness, and dimensional accuracy. Cube samples with 99.7% relative density and a roughness value of 2.1 μm are printed by using the energy density of 100 J/mm3. Moreover, a thin (100 μm thickness) wall structure can be fabricated through optimizing parameters. Finally, the TWS samples with various TPMS structures are manufactured to compare their heat dissipation capability. As a result, TWS sample of TPMS lattice exhibits a larger temperature gradient in the vertical direction compared to the benchmark sample. The steady-state temperature of the sample base presents a 7 K decrease via introducing TWS.
Scratch Behaviour of Bulk Silicon Nitride Ceramics
Authors: Xiao Xiaolan , Deng Jiayun , Xiong Qiang , Yan Qiusheng , Wu Zhengtao , Lin Huatay
Published: June 2021

Si3N4 ceramic is generally recognized as being difficult to machine due to its hardness and brittleness. It is necessary to control the normal load applied and the machined depth of the abrasive particles in order to eliminate surface/subsurface damage and defects during the grinding or polishing. In this study, scratch experiments were conducted on the polished surface of Si3N4 specimens to investigate the brittle–ductile transformation and the evolution of material removal mechanisms. In addition, the cracking behaviour of Si3N4 ceramic was characterized by indentation tests. The Vickers indentation produced cracks that exhibited good developmental integrity and geometric symmetry. The results indicate that the scratch track can be divided into three stages: the ductile regime, the brittle–ductile coexisting stage, and the brittle fracture regime. The critical loads and the corresponding penetration depths of cracking occurrence in Si3N4 were recorded. The material removal of Si3N4 ceramic was primary attributed to ductile regime removal when the load was less than 9.8 N. Microcrack initiation on the subsurface was observed when the penetration depth of the scratch tip reached 8 μm or the depth of the indentation tip reached 3.2 μm. Microcracks expanded rapidly as the load was further increased, resulting in a brittle fracture of the Si3N4 ceramic.
Anti-Helicobacter pylori Activity of Artemisia ludoviciana subsp. mexicana and Two of Its Bioactive Components, Estafiatin and Eupatilin
Authors: Palacios-Espinosa Juan Francisco , Núñez-Aragón Pablo Noé , Gomez-Chang Erika , Linares Edelmira , Bye Robert , Romero Irma
Published: June 2021

Artemisia ludoviciana subsp. mexicana has been traditionally used for the treatment of digestive ailments such as gastritis, whose main etiological agent is Helicobacter pylori. In a previous screening study, the aqueous extract exhibited a good in vitro anti-H. pylori activity. With the aim of determining the efficacy of this species as a treatment for H. pylori related diseases and finding bioactive compounds, its aqueous extract was subjected to solvent partitioning and the fractions obtained were tested for their in vitro anti-H. pylori effect, as well as for their in vivo gastroprotective and anti-inflammatory activities. The aqueous extract showed a MIC = 250 µg/mL. No acute toxicity was induced in mice. A gastroprotection of 69.8 ± 3.8%, as well as anti-inflammatory effects of 47.6 ± 12.4% and 38.8 ± 10.2% (by oral and topical administration, respectively), were attained. Estafiatin and eupatilin were isolated and exhibited anti-H. pylori activity with MBCs of 15.6 and 31.2 µg/mL, respectively. The finding that A. ludoviciana aqueous extract has significant anti-H. pylori, gastroprotective and anti-inflammatory activities is a relevant contribution to the ethnopharmacological knowledge of this species. This work is the first report about the in vivo gastroprotective activity of A. ludoviciana and the anti-H. pylori activity of eupatilin and estafiatin.
Nucleophilic Substitution at Tetracoordinate Phosphorus. Stereochemical Course and Mechanisms of Nucleophilic Displacement Reactions at Phosphorus in Diastereomeric cis- and trans-2-Halogeno-4-methyl-1,3,2-dioxaphosphorinan-2-thiones: Experimental and DFT Studies
Authors: Mikołajczyk Marian , Ziemnicka Barbara , Krzywański Jan , Cypryk Marek , Gostyński Bartłomiej
Published: June 2021

Geometrical cis- and trans- isomers of 2-chloro-, 2-bromo- and 2-fluoro-4-methyl-1,3,2-dioxaphosphorinan-2-thiones were obtained in a diastereoselective way by (a) sulfurization of corresponding cyclic PIII-halogenides, (b) reaction of cyclic phosphorothioic acids with phosphorus pentachloride and (c) halogen–halogen exchange at PIV-halogenide. Their conformation and configuration at the C4-ring carbon and phosphorus stereocentres were studied by NMR (1H, 31P) methods, X-ray analysis and density functional (DFT) calculations. The stereochemistry of displacement reactions (alkaline hydrolysis, methanolysis, aminolysis) at phosphorus and its mechanism were shown to depend on the nature of halogen. Cyclic cis- and trans-isomers of chlorides and bromides react with nucleophiles (HO−, CH3O−, Me2NH) with inversion of configuration at phosphorus. DFT calculations provided evidence that alkaline hydrolysis of cyclic thiophosphoryl chlorides proceeds according to the SN2-P mechanism with a single transition state according to the potential energy surface (PES) observed. The alkaline hydrolysis reaction of cis- and trans-fluorides afforded the same mixture of the corresponding cyclic thiophosphoric acids with the thermodynamically more stable major product. Similar DFT calculations revealed that substitution at phosphorus in fluorides proceeds stepwise according to the A–E mechanism with formation of a pentacoordinate intermediate since a PES with two transition states was observed.
Polymer Nanocomposites of Selenium Biofabricated Using Fungi
Authors: Tsivileva Olga , Pozdnyakov Alexander , Ivanova Anastasiya
Published: June 2021

Nanoparticle-reinforced polymer-based materials effectively combine the functional properties of polymers and unique characteristic features of NPs. Biopolymers have attained great attention, with perspective multifunctional and high-performance nanocomposites exhibiting a low environmental impact with unique properties, being abundantly available, renewable, and eco-friendly. Nanocomposites of biopolymers are termed green biocomposites. Different biocomposites are reported with numerous inorganic nanofillers, which include selenium. Selenium is a micronutrient that can potentially be used in the prevention and treatment of diseases and has been extensively studied for its biological activity. SeNPs have attracted increasing attention due to their high bioavailability, low toxicity, and novel therapeutic properties. One of the best routes to take advantage of SeNPs’ properties is by mixing these NPs with polymers to obtain nanocomposites with functionalities associated with the NPs together with the main characteristics of the polymer matrix. These nanocomposite materials have markedly improved properties achieved at low SeNP concentrations. Composites based on polysaccharides, including fungal beta-glucans, are bioactive, biocompatible, biodegradable, and have exhibited an innovative potential. Mushrooms meet certain obvious requirements for the green entity applied to the SeNP manufacturing. Fungal-matrixed selenium nanoparticles are a new promising biocomposite material. This review aims to give a summary of what is known by now about the mycosynthesized selenium polymeric nanocomposites with the impact on fungal-assisted manufactured ones, the mechanisms of the involved processes at the chemical reaction level, and problems and challenges posed in this area.
Limited Lactosylation of Beta-Lactoglobulin from Cow’s Milk Exerts Strong Influence on Antigenicity and Degranulation of Mast Cells
Authors: Bosman Gerlof P. , Oliveira Sergio , Simons Peter J. , Sastre Torano Javier , Somsen Govert W. , Knippels Leon M. J. , Haselberg Rob , Pieters Roland J. , Garssen Johan , Knipping Karen
Published: June 2021

Background: beta-lactoglobulin (BLG) is one of the major cow’s milk proteins and the most abundant allergen in whey. Heating is a common technologic treatment applied during milk transformational processes. Maillardation of BLG in the presence of reducing sugars and elevated temperatures may influence its antigenicity and allergenicity. Primary objective: to analyze and identify lactosylation sites by capillary electrophoresis mass spectrometry (CE-MS). Secondary objective: to assess the effect of lactosylated BLG on antigenicity and degranulation of mast cells. Methods: BLG was lactosylated at pH 7, a water activity (aw) of 0.43, and a temperature of 65 °C using a molar ratio BLG:lactose of 1:1 by incubating for 0, 3, 8, 16 or 24 h. For the determination of the effect on antibody-binding capacity of lactosylated BLG, an ELISA was performed. For the assessment of degranulation of the cell-line RBL-hεIa-2B12 transfected with the human α-chain, Fcε receptor type 1 (FcεRI) was used. Results: BLG showed saturated lactosylation between 8 and 16 incubation hours in our experimental setup. Initial stage lactosylation sites L1 (N-terminus)—K47, K60, K75, K77, K91, K138 and K141—have been identified using CE-MS. Lactosylated BLG showed a significant reduction of both the IgG binding (p = 0.0001) as well as degranulation of anti-BLG IgE-sensitized RBL-hεIa-2B12 cells (p < 0.0001). Conclusions and clinical relevance: this study shows that lactosylation of BLG decreases both the antigenicity and degranulation of mast cells and can therefore be a promising approach for reducing allergenicity of cow’s milk allergens provided that the process is well-controlled.
Examining the Correlates of Adolescent Food and Nutrition Knowledge
Authors: Brown Rachel , Seabrook Jamie A. , Stranges Saverio , Clark Andrew F. , Haines Jess , O’Connor Colleen , Doherty Sean , Gilliland Jason A.
Published: June 2021

Food literacy is a set of skills and knowledge that are integral to diet. It is common among teenagers to not have basic food literacy skills needed to consume a healthy diet. This study examined: (1) the current state of food and nutrition knowledge among adolescents 13–19 years of age in the census metropolitan area of London, ON, Canada; and (2) correlates of food knowledge and nutrition knowledge among adolescents. Data for this study were drawn from baseline youth and parent survey data collected from a larger population health intervention study. Statistical analysis of the survey data indicates that higher parental education and higher median neighbourhood family income, the use of mobile health applications, liking to cook, as well as confidence in reading and understanding food labels were all consistently associated with increased food and nutrition knowledge. Findings may help guide future research towards optimal methods for delivering food literacy interventions to effectively educate teenagers. Results of this study may help guide policy makers, researchers, and public health professionals in developing appropriate food and nutrition programs and curriculums to combat the decline in food literacy skills.
The Effects of Lifestyle and Diet on Gut Microbiota Composition, Inflammation and Muscle Performance in Our Aging Society
Authors: Strasser Barbara , Wolters Maike , Weyh Christopher , Krüger Karsten , Ticinesi Andrea
Published: June 2021

Living longer is associated with an increased risk of chronic diseases, including impairments of the musculoskeletal and immune system as well as metabolic disorders and certain cancers, each of which can negatively affect the relationship between host and microbiota up to the occurrence of dysbiosis. On the other hand, lifestyle factors, including regular physical exercise and a healthy diet, can affect skeletal muscle and immune aging positively at all ages. Accordingly, health benefits could partly depend on the effect of such interventions that influence the biodiversity and functionality of intestinal microbiota. In the present review, we first discuss the physiological effects of aging on the gut microbiota, immune system, and skeletal muscle. Secondly, we describe human epidemiological evidence about the associations between physical activity and fitness and the gut microbiota composition in older adults. The third part highlights the relevance and restorative mechanisms of immune protection through physical activity and specific exercise interventions during aging. Fourth, we present important research findings on the effects of exercise and protein as well as other nutrients on skeletal muscle performance in older adults. Finally, we provide nutritional recommendations to prevent malnutrition and support healthy active aging with a focus on gut microbiota. Key nutrition-related concerns include the need for adequate energy and protein intake for preventing low muscle mass and a higher demand for specific nutrients (e.g., dietary fiber, polyphenols and polyunsaturated fatty acids) that can modify the composition, diversity, and metabolic capacity of the gut microbiota, and may thus provide a practical means of enhancing gut and systemic immune function.
Dietary Patterns in Early Childhood and the Risk of Childhood Overweight: The GECKO Drenthe Birth Cohort
Authors: Sirkka Outi , Fleischmann Maria , Abrahamse-Berkeveld Marieke , Halberstadt Jutka , Olthof Margreet R. , Seidell Jacob C. , Corpeleijn Eva
Published: June 2021

Limited and inconsistent evidence exists on the associations between dietary patterns and overweight during childhood. The present study describes dietary patterns of three-year-old Dutch children and associations between childhood overweight and body mass index (BMI) development between 3 and 10 years. In the GECKO Drenthe birth cohort (N = 1306), body height and weight were measured around the age of 3, 4, 5, and 10 years, and overweight was defined according to Cole and Lobstein. A validated food frequency questionnaire (FFQ) was used to measure diet at 3 years. Dietary patterns were derived using principal components analysis (PCA). Using logistic regression analyses, pattern scores were related to overweight at 3 and 10 years. A linear mixed-effect model was used to estimate BMI-SDS development between 3 to 10 years according to quartiles of adherence to the pattern scores. Two dietary patterns were identified: (1) ‘minimally processed foods’, indicating high intakes of vegetables/sauces/savory dishes, and (2) ‘ultra-processed foods’, indicating high intakes of white bread/crisps/sugary drinks. A 1 SD increase in the ‘ultra-processed foods’ pattern score increased the odds of overweight at 10 years (adjusted OR: 1.30; 95%CI: 1.08, 1.57; p = 0.006). The ‘minimally processed foods’ pattern was not associated with overweight. Although a high adherence to both dietary patterns was associated with a higher BMI-SDS up to 10 years of age, a stronger association for the ‘ultra-processed foods’ pattern was observed (p < 0.001). A dietary pattern high in energy-dense and low-fiber ultra-processed foods at 3 years is associated with overweight and a high BMI-SDS later in childhood.
Estimated Prevalence and Care Pathway of Feeding and Eating Disorders in a French Pediatric Population
Authors: Bertrand Valérie , Tiburce Lyvia , Sabatier Thibaut , Dufour Damien , Déchelotte Pierre , Tavolacci Marie-Pierre
Published: June 2021

Feeding and Eating Disorders (FED) are mostly described in infants and adolescents but are less well-known in children. Information on the prevalence of FED in the general pediatric population is still limited. The aim of this study was to estimate the prevalence and the care pathway of FED in a population aged 0–18 years old, using the Diagnostic and Statistical Manual of Mental Disorders (DSM)-5 classification. Two physicians interviewed 401 families using a questionnaire including demographics, BMI, dietary behavior data, and age-appropriate screening tools. Qualitative and quantitative variables were compared using the Chi2 test and Student’s t-test, respectively. After a headcount adjustment based on the French population by age group, the estimated prevalence rate was 3% [95%CI (1.7–5.1)] for Avoidant and Restrictive Food Intake Disorder (ARFID), and 9.7% [95%CI (7.2–13.0)] for Unspecified FED (UFED), which included other restrictive and compulsive FED. The median age for ARFID was 4.8 years (0.8–9 years), and 7.5 years (0.6–17 years) for UFED. The interviews did not identify cases of anorexia, bulimia, binge eating disorder, other specified FED, pica or rumination. Only 15.2% of children with an FED were receiving medical care. The development of validated pediatric screening tools, as well as the training of health professionals in children FED is necessary.
Prevalence and Factors Associated with the Triple Burden of Malnutrition among Mother-Child Pairs in Sub-Saharan Africa
Authors: Ahinkorah Bright Opoku , Amadu Iddrisu , Seidu Abdul-Aziz , Okyere Joshua , Duku Eric , Hagan John Elvis , Budu Eugene , Archer Anita Gracious , Yaya Sanni
Published: June 2021

Despite concerns about the coexistence of overnutrition, undernutrition and micronutrient deficiencies, which is compositely referred to as the triple burden of malnutrition (TBM), little is known about the phenomenon in sub-Saharan Africa (SSA). We, therefore, aimed to examine the prevalence and investigate the factors associated with TBM in SSA. This study uses cross-sectional survey data collected through the Demographic and Health Surveys (DHS) Program from 2010 to 2019. Data from 32 countries in SSA were used for the analysis. The prevalence of TBM were presented in tables and maps using percentages. The predictors of TBM were examined by fitting a negative log-log regression to the data. The results were then presented using adjusted odds ratios (aORs) at 95% Confidence Intervals (CIs). Out of the 169,394 children, 734 (1%) suffered from TBM. The highest proportion of children with TBM in the four geographic regions in SSA was found in western Africa (0.75%) and the lowest in central Africa (0.21%). Children aged 1 [aOR = 1.283; 95% CI = 1.215–1.355] and those aged 2 [aOR = 1.133; 95% CI = 1.067–1.204] were more likely to experience TBM compared to those aged 0. TBM was less likely to occur among female children compared to males [aOR = 0.859; 95% CI = 0.824–0.896]. Children whose perceived size at birth was average [aOR = 1.133; 95% CI = 1.076–1.193] and smaller than average [aOR = 1.278; 95% CI = 1.204–1.356] were more likely to suffer from TBM compared to those who were larger than average at birth. Children born to mothers with primary [aOR = 0.922; 95% CI = 0.865–0.984] and secondary [aOR = 0.829; 95% CI = 0.777–0.885] education were less likely to suffer from TBM compared to those born to mothers with no formal education. Children born to mothers who attended antenatal care (ANC) had lower odds of experiencing TBM compared to those born to mothers who did not attend ANC [aOR = 0.969; 95% CI = 0.887–0.998]. Children born to mothers who use clean household cooking fuel were less likely to experience TBM compared to children born to mothers who use unclean household cooking fuel [aOR = 0.724; 95% CI = 0.612–0.857]. Essentially, higher maternal education, ANC attendance and use of clean cooking fuel were protective factors against TBM, whereas higher child age, low size at birth and being a male child increased the risk of TBM. Given the regional variations in the prevalence and risk of TBM, region-specific interventions must be initiated to ensure the likelihood of those interventions being successful at reducing the risk of TBM. Countries in Western Africa in particular would have to strengthen their current policies and programmes on malnutrition to enhance their attainment of the SDGs.
Enablers and Barriers of Zinc Fortification; Experience from 10 Low- and Middle-Income Countries with Mandatory Large-Scale Food Fortification
Authors: Tarini Ann , Manger Mari S. , Brown Kenneth H. , Mbuya Mduduzi N. N. , Rowe Laura A. , Grant Frederick , Black Robert E. , McDonald Christine M.
Published: June 2021

Adequate zinc nutrition is important for child growth, neurodevelopment, immune function, and normal pregnancy outcomes. Seventeen percent of the global population is estimated to be at risk for inadequate zinc intake. However, zinc is not included in the fortification standards of several low- and middle-income countries with mandatory fortification programs, despite data suggesting a zinc deficiency public health problem. To guide policy decisions, we investigated the factors enabling and impeding the inclusion of zinc as a fortificant by conducting in-depth interviews with 17 key informants from 10 countries. Findings revealed the decision to include zinc was influenced by guidance from international development partners and enabled by the assessment of zinc deficiency, mandatory regional food fortification standards which included zinc, the World Health Organization (WHO) guidelines for zinc fortification, and the low cost of zinc compound commonly used. Barriers included the absence of zinc from regional fortification standards, limited available data on the efficacy and effectiveness of zinc fortification, and the absence of national objectives related to the prevention of zinc deficiency. To promote zinc fortification there is a need to put the prevention of zinc deficiency higher on the international nutrition agenda and to promote large-scale food fortification as a key deficiency mitigation strategy.
“Just So You Know, It Has Been Hard”: Food Retailers’ Perspectives of Implementing a Food and Nutrition Policy in Public Healthcare Settings
Authors: Law Kristy Karying , Pulker Claire Elizabeth , Healy Janelle Diann , Pollard Christina Mary
Published: June 2021

Mandated policies to improve food environments in public settings are an important strategy for governments. Most Australian governments have mandated policies or voluntary standards for healthy food procurement in healthcare facilities, however, implementation and compliance are poor. A better understanding of the support required to successfully implement such policies is needed. This research explored food retailers’ experiences in implementing a mandated food and nutrition policy (the Policy) in healthcare settings to identify barriers, enablers, and impacts of compliance. Three 90-min workshops facilitated by two public health practitioners were undertaken with 12 food retailers responsible for operating 44 outlets across four hospitals in Perth, Western Australia. Workshop discussions were transcribed non-verbatim and inductive thematic content was analyzed. Three main themes were identified: (1) food retailers had come to accept their role in implementing the Policy; (2) the Policy made it difficult for food retailers to operate successfully, and; (3) food retailers needed help and support to implement the Policy. Findings indicate the cost of implementation is borne by food retailers. Communications campaigns, centralized databases of classified products, reporting frameworks, recognition of achievements, and dedicated technical expertise would support achieving policy compliance. Feasibility assessments prior to policy implementation are recommended for policy success.
Recent Advances in Polymer-Based Vaginal Drug Delivery Systems
Authors: Osmałek Tomasz , Froelich Anna , Jadach Barbara , Tatarek Adam , Gadziński Piotr , Falana Aleksandra , Gralińska Kinga , Ekert Michał , Puri Vinam , Wrotyńska-Barczyńska Joanna , Michniak-Kohn Bozena
Published: June 2021

The vagina has been considered a potential drug administration route for centuries. Most of the currently marketed and investigated vaginal formulations are composed with the use of natural or synthetic polymers having different functions in the product. The vaginal route is usually investigated as an administration site for topically acting active ingredients; however, the anatomical and physiological features of the vagina make it suitable also for drug systemic absorption. In this review, the most important natural and synthetic polymers used in vaginal products are summarized and described, with special attention paid to the properties important in terms of vaginal application. Moreover, the current knowledge on the commonly applied and innovative dosage forms designed for vaginal administration was presented. The aim of this work was to highlight the most recent research directions and indicate challenges related to vaginal drug administrations. As revealed in the literature overview, intravaginal products still gain enormous scientific attention, and novel polymers and formulations are still explored. However, there are research areas that require more extensive studies in order to provide the safety of novel vaginal products.
Potential Applications of Chitosan-Based Nanomaterials to Surpass the Gastrointestinal Physiological Obstacles and Enhance the Intestinal Drug Absorption
Authors: Pathomthongtaweechai Nutthapoom , Muanprasat Chatchai
Published: June 2021

The small intestine provides the major site for the absorption of numerous orally administered drugs. However, before reaching to the systemic circulation to exert beneficial pharmacological activities, the oral drug delivery is hindered by poor absorption/metabolic instability of the drugs in gastrointestinal (GI) tract and the presence of the mucus layer overlying intestinal epithelium. Therefore, a polymeric drug delivery system has emerged as a robust approach to enhance oral drug bioavailability and intestinal drug absorption. Chitosan, a cationic polymer derived from chitin, and its derivatives have received remarkable attention to serve as a promising drug carrier, chiefly owing to their versatile, biocompatible, biodegradable, and non-toxic properties. Several types of chitosan-based drug delivery systems have been developed, including chemical modification, conjugates, capsules, and hybrids. They have been shown to be effective in improving intestinal assimilation of several types of drugs, e.g., antidiabetic, anticancer, antimicrobial, and anti-inflammatory drugs. In this review, the physiological challenges affecting intestinal drug absorption and the effects of chitosan on those parameters impacting on oral bioavailability are summarized. More appreciably, types of chitosan-based nanomaterials enhancing intestinal drug absorption and their mechanisms, as well as potential applications in diabetes, cancers, infections, and inflammation, are highlighted. The future perspective of chitosan applications is also discussed.
Digital Sublimation Printing on Knitted Polyamide 6.6 Fabric Treated with Non-Thermal Plasma
Authors: Silva Marcia Cristina , Petraconi Gilberto , Cecci Ricardo Rodrigues Ramos , Passos Adriano Alves , do Valle Wanderson Ferraz , Braite Bruno , Lourenço Sérgio Ricardo , Gasi Fernando
Published: June 2021

The garment industry demands stamping processes that are increasingly more agile and less damaging to the environment. In this scenario, digital printing, with the sublimation transfer printing technique, presents itself as a viable option for synthetic textile substrates. Among the synthetic fibres, polyamide (P.A.) fibres stand out, as they are light, soft, durable, and boast moderate sweat absorption; however, before sublimation, superficial treatment is necessary in order to present good results such as withstanding washing and maintaining colour intensity. This study addresses the surface modification of the PA6.6 textile substrate by activating non-thermal plasma at atmospheric pressure to receive dye through the sublimation method with dispersed dye. The knitted PA6.6 fabric surface treatment was performed with plasma application at atmospheric pressure using air in the Plasmatreater AS400 equipment. The sublimation transfer effects were evaluated by wash fastness and colourimetric tests. To assess the wettability effect of the control and treated samples, a contact angle test was carried out on PA6.6 samples. Fourier transform infrared spectroscopy (FTIR) proved the changes in chemical functional groups in the fibres. The results showed a decrease in the contact angle of the textile surface, 4–5 grayscale results for colour change and transfer for washing, and an increase in colour strength. In the FTIR tests, there is an increase in the transmittance value of aromatic, carboxylic groups (C=O, 580 cm−1), amides (N=H, 1630 cm−1), and methyl groups (CH 1369 to 1463 cm−1) as well as the presence of new functional groups in the 3064 cm−1 and 2860 cm−1 bands. These conditions allowed sublimation in the knitted PA6.6 fabric and showed increased colour strength and good wash fastness.
Performance Analysis of Indentation Punch on High Energy Lithium Pouch Cells and Simulated Model Improvement
Authors: Ye Lihua , Ashfaq Muhammad Muzamal , Shi Aiping , Shah Syyed Adnan Raheel , Shi Yefan
Published: June 2021

In this research, the aim relates to the material characterization of high-energy lithium-ion pouch cells. The development of appropriate model cell behavior is intended to simulate two scenarios: the first is mechanical deformation during a crash and the second is an internal short circuit in lithium-ion cells during the actual effect scenarios. The punch test has been used as a benchmark to analyze the effects of different state of charge conditions on high-energy lithium-ion battery cells. This article explores the impact of three separate factors on the outcomes of mechanical punch indentation experiments. The first parameter analyzed was the degree of prediction brought about by experiments on high-energy cells with two different states of charge (greater and lesser), with four different sizes of indentation punch, from the cell’s reaction during the indentation effects on electrolyte. Second, the results of the loading position, middle versus side, are measured at quasi-static speeds. The third parameter was the effect on an electrolyte with a different state of charge. The repeatability of the experiments on punch loading was the last test function analyzed. The test results of a greater than 10% state of charge and less than 10% state of charge were compared to further refine and validate this modeling method. The different loading scenarios analyzed in this study also showed great predictability in the load-displacement reaction and the onset short circuit. A theoretical model of the cell was modified for use in comprehensive mechanical deformation. The overall conclusion found that the loading initiating the cell’s electrical short circuit is not instantaneously instigated and it is subsequently used to process the development of a precise and practical computational model that will reduce the chances of the internal short course during the crash.
Tuning the Adhesive Properties of Soy Protein Wood Adhesives with Different Coadjutant Polymers, Nanocellulose and Lignin
Authors: Podlena Milan , Böhm Martin , Saloni Daniel , Velarde Guillermo , Salas Carlos
Published: June 2021

Commercial wood adhesives are based on products that contain formaldehyde; however, environmental and health concerns about formaldehyde emissions from wood products have influenced research and development efforts in order to find alternative, formaldehyde-free products for wood adhesives. In this work, different soy protein-based wood adhesives are proposed, and their performance is compared to commercial urea formaldehyde (UF) adhesive. Soy protein-based wood adhesives were prepared using either soy protein isolate (SPI) or soy protein flour (SF) with different coadjutant polymers: polyethylene oxide (PEO), hydroxypropyl methylcellulose (HPMC), cellulose nanofibrils (CNF) or polyvinyl alcohol (PVA) with and without addition of kraft lignin. The effects of the type of soy protein, solids content, coadjutant polymer and lignin addition were investigated. The wood adhesive formulations were tested on the bonding of hardwood (white maple) and softwood (southern yellow pine) and the dry shear strength of test specimens was measured according to method ASTM D905-08. The adhesive formulations with SPI achieved significantly higher values than those with SF. The dry shear strength of the adhesives varies depending on the coadjutant polymer, the wood species and the addition of lignin.