bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Methods and References from Acquired Resistance to the Mutant-Selective EGFR Inhibitor AZD9291 Is Associated with Increased Dependence on RAS Signaling in Preclinical Models
Authors: Eberlein Catherine A. , Stetson Daniel , Markovets Aleksandra A. , Al-Kadhimi Katherine J. , Lai Zhongwu , Fisher Paul R. , Meador Catherine B. , Spitzler Paula , Ichihara Eiki , Ross Sarah J. , Ahdesmaki Miika J. , Ahmed Ambar , Ratcliffe Laura E. , O'Brien Elizabeth L. Christey , Barnes Claire H. , Brown Henry , Smith Paul D. , Dry Jonathan R. , Beran Garry , Thress Kenneth S. , Dougherty Brian , Pao William , Cross Darren A.E.
Published: March 2023

Supplementary Methods and References. Description of additional methods and procedures used in the study. Also includes Supplementary References.
Supplementary Figures S1-S5 from Chemoradiotherapy-Induced Upregulation of PD-1 Antagonizes Immunity to HPV-Related Oropharyngeal Cancer
Authors: Parikh Falguni , Duluc Dorothée , Imai Naoko , Clark Amelia , Misiukiewicz Krzys , Bonomi Marcello , Gupta Vishal , Patsias Alexis , Parides Michael , Demicco Elizabeth G. , Zhang David Y. , Kim-Schulze Seunghee , Kao Johnny , Gnjatic Sacha , Oh Sangkon , Posner Marshall R. , Sikora Andrew G.
Published: March 2023

All supplementary Figures S1-S5. FIGURE S1. Gating scheme. FIGURE S2. Effect of chemoradiation on circulating immunocytes. FIGURE S3. Intracellular IFN-γ and TNF-α staining in CD8+ and CD4+ T cells. FIGURE S4. Effect of chemoradiotherapy on PD-1 expression on CD8+T cells. FIGURE S5. Baseline PD-1 expression is correlated with post-treatment PD-1 expression on CD4+ T cells.
Supplementary Figure S7. Responses to SPARCL1-coated beads are concentration dependent. from Androgen-Regulated SPARCL1 in the Tumor Microenvironment Inhibits Metastatic Progression
Authors: Hurley Paula J. , Hughes Robert M. , Simons Brian W. , Huang Jessie , Miller Rebecca M. , Shinder Brian , Haffner Michael C. , Esopi David , Kimura Yasunori , Jabbari Javaneh , Ross Ashley E. , Erho Nicholas , Vergara Ismael A. , Faraj Sheila F. , Davicioni Elai , Netto George J. , Yegnasubramanian Srinivasan , An Steven S. , Schaeffer Edward M.
Published: March 2023

Supplementary Figure S7
Supplementary Figure S6. SPARCL1 engages cell-ECM interactions. from Androgen-Regulated SPARCL1 in the Tumor Microenvironment Inhibits Metastatic Progression
Authors: Hurley Paula J. , Hughes Robert M. , Simons Brian W. , Huang Jessie , Miller Rebecca M. , Shinder Brian , Haffner Michael C. , Esopi David , Kimura Yasunori , Jabbari Javaneh , Ross Ashley E. , Erho Nicholas , Vergara Ismael A. , Faraj Sheila F. , Davicioni Elai , Netto George J. , Yegnasubramanian Srinivasan , An Steven S. , Schaeffer Edward M.
Published: March 2023

Supplementary Figure S6
Supplementary Figure S1. Androgen suppresses SPARCL1 expression. from Androgen-Regulated SPARCL1 in the Tumor Microenvironment Inhibits Metastatic Progression
Authors: Hurley Paula J. , Hughes Robert M. , Simons Brian W. , Huang Jessie , Miller Rebecca M. , Shinder Brian , Haffner Michael C. , Esopi David , Kimura Yasunori , Jabbari Javaneh , Ross Ashley E. , Erho Nicholas , Vergara Ismael A. , Faraj Sheila F. , Davicioni Elai , Netto George J. , Yegnasubramanian Srinivasan , An Steven S. , Schaeffer Edward M.
Published: March 2023

Supplementary Figure S1
Supplementary Experimental Procedures, Supplementary Figure Legends, and Supplementary Tables 1 through 3 from c-Myc Alterations Confer Therapeutic Response and Acquired Resistance to c-Met Inhibitors in MET-Addicted Cancers
Authors: Shen Aijun , Wang Lu , Huang Min , Sun Jingya , Chen Yi , Shen Yan-Yan , Yang Xinying , Wang Xin , Ding Jian , Geng Meiyu
Published: March 2023

Supplementary Experimental Procedures and Figure Legends. Supplementary Table 1-Comparison of secreted proteins in the culture medium of EBC-1 and EBC-1/SR cells using L-series 507 antibody array. Supplementary Table 2-Names and significant targets of 42 compounds tested against EBC-1/SR and MKN-45/SR cells as single agents or in combination with SGX-523. Supplementary Table 3-Established patient derived xenograft models (more than 10) for in vivo efficacy studies.
Supplementary Figures S1-S6 from Warfarin Blocks Gas6-Mediated Axl Activation Required for Pancreatic Cancer Epithelial Plasticity and Metastasis
Authors: Kirane Amanda , Ludwig Kathleen F. , Sorrelle Noah , Haaland Gry , Sandal Tone , Ranaweera Renate , Toombs Jason E. , Wang Miao , Dineen Sean P. , Micklem David , Dellinger Michael T. , Lorens James B. , Brekken Rolf A.
Published: March 2023

Supplementary Figures S1-S6. Axl is required for the growth of Mia PaCa-2 tumors (S1); Characterization of 10C9 (S2); Warfarin inhibits autocrine activation of Axl in pancreatic tumor cells (S3); In vivo warfarin effects (S4); Maintenance of mesenchymal phenotype is Axl dependent and inhibited by warfarin (S5); Acquisition of Axl expression sensitizes Capan-EMT cells to warfarin (S6).
Supplemental File 2 from CDK2 Inhibition Causes Anaphase Catastrophe in Lung Cancer through the Centrosomal Protein CP110
Authors: Hu Shanhu , Danilov Alexey V. , Godek Kristina , Orr Bernardo , Tafe Laura J. , Rodriguez-Canales Jaime , Behrens Carmen , Mino Barbara , Moran Cesar A. , Memoli Vincent A. , Mustachio Lisa Maria , Galimberti Fabrizio , Ravi Saranya , DeCastro Andrew , Lu Yun , Sekula David , Andrew Angeline S. , Wistuba Ignacio I. , Freemantle Sarah , Compton Duane A. , Dmitrovsky Ethan
Published: March 2023

Supplemental File S2. A representative video of a Hop62 cell that undergoes multipolar cell division.
Supplementary Table S2 from Tropomodulin 1 Expression Driven by NF-κB Enhances Breast Cancer Growth
Authors: Ito-Kureha Taku , Koshikawa Naohiko , Yamamoto Mizuki , Semba Kentaro , Yamaguchi Noritaka , Yamamoto Tadashi , Seiki Motoharu , Inoue Jun-ichiro
Published: March 2023

Supplementary Table S2. A list of genes whose expressions were reduced more than 2-fold in IκBαSR-expressing cells when compared with both mock- and GFP-infected cells.
Supplementary Figure S3 from Tropomodulin 1 Expression Driven by NF-κB Enhances Breast Cancer Growth
Authors: Ito-Kureha Taku , Koshikawa Naohiko , Yamamoto Mizuki , Semba Kentaro , Yamaguchi Noritaka , Yamamoto Tadashi , Seiki Motoharu , Inoue Jun-ichiro
Published: March 2023

Supplementary Figure S3. TMOD1 positively regulates MMP13 expression and activity.
Supplementary Figure Legends from Tropomodulin 1 Expression Driven by NF-κB Enhances Breast Cancer Growth
Authors: Ito-Kureha Taku , Koshikawa Naohiko , Yamamoto Mizuki , Semba Kentaro , Yamaguchi Noritaka , Yamamoto Tadashi , Seiki Motoharu , Inoue Jun-ichiro
Published: March 2023

Supplementary Figure Legends. Legends for Supplementary Figures S1-S4.
Supplementary Figure 2 from PML/RARα-Regulated miR-181a/b Cluster Targets the Tumor Suppressor RASSF1A in Acute Promyelocytic Leukemia
Authors: Bräuer-Hartmann Daniela , Hartmann Jens-Uwe , Wurm Alexander Arthur , Gerloff Dennis , Katzerke Christiane , Verga Falzacappa Maria Vittoria , Pelicci Pier Giuseppe , Müller-Tidow Carsten , Tenen Daniel G. , Niederwieser Dietger , Behre Gerhard
Published: March 2023

Western blot analysis of p53 protein in puromycin and gfp sorted miR-ZIP-expressing NB4 cells. GAPDH was used as internal control. Values below the blots represent the median {plus minus} SD from three independent experiments.
Supplementary Figure 1 from PML/RARα-Regulated miR-181a/b Cluster Targets the Tumor Suppressor RASSF1A in Acute Promyelocytic Leukemia
Authors: Bräuer-Hartmann Daniela , Hartmann Jens-Uwe , Wurm Alexander Arthur , Gerloff Dennis , Katzerke Christiane , Verga Falzacappa Maria Vittoria , Pelicci Pier Giuseppe , Müller-Tidow Carsten , Tenen Daniel G. , Niederwieser Dietger , Behre Gerhard
Published: March 2023

A, Apoptosis assay in NB4 cells 24h and 48h after application of As2O3 (1 µM). B, FACS analysis for CD11b expression in As2O3 treated NB4 cells 48h after application. C, qPCR analysis for C/EBPβ mRNA expression in NB4 cells after As2O3 application. D, Apoptosis assay in NB4 cells 48h after application of doxorubicin (0.01 µg/ml) with or without cytarabine (0.05 µM). E, qPCR analys for C/EBPβ mRNA expression in NB4 cells after doxorubicin and cytarabine application. For qPCR measurement GAPDH was used as control. Bars and values in the dot blots represent the median {plus minus} SD from three independent experiments.* p-value {less than or equal to} 0.05; ** p-value {less than or equal to} 0.01.
Supplementary Materials and Methods from Neuroendocrine Transdifferentiation in Human Prostate Cancer Cells: An Integrated Approach
Authors: Cerasuolo Marianna , Paris Debora , Iannotti Fabio A. , Melck Dominique , Verde Roberta , Mazzarella Enrico , Motta Andrea , Ligresti Alessia
Published: March 2023

Supplementary Materials and Methods
Supplementary Figure S3 from Neuroendocrine Transdifferentiation in Human Prostate Cancer Cells: An Integrated Approach
Authors: Cerasuolo Marianna , Paris Debora , Iannotti Fabio A. , Melck Dominique , Verde Roberta , Mazzarella Enrico , Motta Andrea , Ligresti Alessia
Published: March 2023

Supplementary Figure S3. O2PLS regression coefficients representing correlation between polar (A-G) and lipophilic metabolites (H-I) with transcripts.
Supplementary Figure Legend from TUSC4 Functions as a Tumor Suppressor by Regulating BRCA1 Stability
Authors: Peng Yang , Dai Hui , Wang Edward , Lin Curtis Chun-Jen , Mo Wei , Peng Guang , Lin Shiaw-Yih
Published: March 2023

Legend for Supplementary Figures S1-S5.
Supplementary Methods from Chemotherapeutic Agents Subvert Tumor Immunity by Generating Agonists of Platelet-Activating Factor
Authors: Sahu Ravi P. , Ocana Jesus A. , Harrison Kathleen A. , Ferracini Matheus , Touloukian Christopher E. , Al-Hassani Mohammed , Sun Louis , Loesch Mathew , Murphy Robert C. , Althouse Sandra K. , Perkins Susan M. , Speicher Paul J. , Tyler Douglas S. , Konger Raymond L. , Travers Jeffrey B.
Published: March 2023

Supplementary Methods. Supplementary Mass spectrometric methodology
Supplementary Tables S11 and S12 for Dang et al from ΔNp63α Promotes Breast Cancer Cell Motility through the Selective Activation of Components of the Epithelial-to-Mesenchymal Transition Program
Authors: Dang Tuyen T. , Esparza Matthew A. , Maine Erin A. , Westcott Jill M. , Pearson Gray W.
Published: March 2023

Supplementary tables related to reagents used.
Supplemetal Material and Methods, Figure 1-7 and Table 1 from Defects in the Fanconi Anemia Pathway and Chromatid Cohesion in Head and Neck Cancer
Authors: Stoepker Chantal , Ameziane Najim , van der Lelij Petra , Kooi Irsan E. , Oostra Anneke B. , Rooimans Martin A. , van Mil Saskia E. , Brink Arjen , Dietrich Ralf , Balk Jesper A. , Ylstra Bauke , Joenje Hans , Feller Stephan M. , Brakenhoff Ruud H.
Published: March 2023

Supplemental Material and Methods. Supplemental Figure S1. Cell cycle analysis in FA and sporadic HNSCC cell lines upon ICL treatment. Supplemental Figure S2. FANCM protein expression is absent in FaDu cells. Supplemental Figure S3. Overview of possible pathogenic variants in genes that are frequently altered in HNSCC. Supplemental Figure S4. PARP inhibitor resistance and normal RAD51 focus formation in VU-SCC-147. Supplemental Figure S5. Cell line UPCI-SCC-154 is sensitive to cisplatin. Supplemental Figure S6. Cell line VU-SCC-41 is mutated in PSC5A. Supplemental Figure S7. Mutational inactivation of STAG2 in cell line VU-SCC-78. Supplemental Table 1. Separate panel of 39 sporadic HNSCC cell lines.
Supplementary Tables S1-S3 for Dang et al from ΔNp63α Promotes Breast Cancer Cell Motility through the Selective Activation of Components of the Epithelial-to-Mesenchymal Transition Program
Authors: Dang Tuyen T. , Esparza Matthew A. , Maine Erin A. , Westcott Jill M. , Pearson Gray W.
Published: March 2023

Supplementary tables related to miRNA wounding screen.
Supplementary Figures, Legends, and Methods from ΔNp63α Promotes Breast Cancer Cell Motility through the Selective Activation of Components of the Epithelial-to-Mesenchymal Transition Program
Authors: Dang Tuyen T. , Esparza Matthew A. , Maine Erin A. , Westcott Jill M. , Pearson Gray W.
Published: March 2023

Contains Supplementary Figures S1-S7, Supplementary Figure Legends and Supplementary Methods.
Supplementary Figures 1 - 4, Table 1 from Anti-CD20 Therapy Acts via FcγRIIIA to Diminish Responsiveness of Human Natural Killer Cells
Authors: Capuano Cristina , Romanelli Maddalena , Pighi Chiara , Cimino Giuseppe , Rago Angela , Molfetta Rosa , Paolini Rossella , Santoni Angela , Galandrini Ricciarda
Published: March 2023

Supplementary Figure Legends - Supplementary Figure Legends 1- 4. Supplementary Figure 1 - Evaluation of CD16 internalization upon rituximab- or ofatumumab-opsonised target interaction. Supplementary Figure 2 - Analysis of cytotoxic activity and degranulation induced by individual activating receptors. Supplementary Figure 3 - Rituximab-induced hyporesponsiveness is independent from IL-2 treatment. Supplementary Figure 4 - Lytic granule exocytosis is impaired in both CD16+ and CD16 down-regulated rituximab experienced NK cells. Supplementary Table 1 - CLL patient characteristics.
Supplementary Methods from Intratumoral Heterogeneity in EGFR-Mutant NSCLC Results in Divergent Resistance Mechanisms in Response to EGFR Tyrosine Kinase Inhibition
Authors: Soucheray Margaret , Capelletti Marzia , Pulido Inés , Kuang Yanan , Paweletz Cloud P. , Becker Jeffrey H. , Kikuchi Eiki , Xu Chunxiao , Patel Tarun B. , Al-shahrour Fatima , Carretero Julián , Wong Kwok-Kin , Jänne Pasi A. , Shapiro Geoffrey I. , Shimamura Takeshi
Published: March 2023

Description of additional methods and procedures used in the study.
Supplementary Table S6 from Activation Status of the Pregnane X Receptor Influences Vemurafenib Availability in Humanized Mouse Models
Authors: MacLeod A. Kenneth , McLaughlin Lesley A. , Henderson Colin J. , Wolf C. Roland
Published: March 2023

Pharmacokinetic parameters of vemurafenib in huPXR/huCAR/huCYP3A4/3A7 mice pre-treated with RIF and elacridar.
Supplementary Table S3 from Activation Status of the Pregnane X Receptor Influences Vemurafenib Availability in Humanized Mouse Models
Authors: MacLeod A. Kenneth , McLaughlin Lesley A. , Henderson Colin J. , Wolf C. Roland
Published: March 2023

Pharmacokinetic parameters of vemurafenib in Cyp3aKO/Cyp3a13+/+ and huCYP3A4/3A7 mice pre-treated with PCN.
Supplementary Table S2 from Activation Status of the Pregnane X Receptor Influences Vemurafenib Availability in Humanized Mouse Models
Authors: MacLeod A. Kenneth , McLaughlin Lesley A. , Henderson Colin J. , Wolf C. Roland
Published: March 2023

Spearman's rank correlation of OH-vemurafenib formation with probe substrate activities in a panel of HLM.
Supplementary Figures S1-6 from ErbB3–ErbB2 Complexes as a Therapeutic Target in a Subset of Wild-type BRAF/NRAS Cutaneous Melanomas
Authors: Capparelli Claudia , Rosenbaum Sheera , Berman-Booty Lisa D. , Salhi Amel , Gaborit Nadège , Zhan Tingting , Chervoneva Inna , Roszik Jason , Woodman Scott E. , Davies Michael A. , Setiady Yulius Y. , Osman Iman , Yarden Yosef , Aplin Andrew E.
Published: March 2023

Supplementary Figures S1-6 Supplemental Fig. S1. ErbB3 and ErbB4 expression in melanoma cell lines. Supplemental Fig. S2. Depletion of NRG1 inhibits ErbB3 downstream signaling and cell growth in WT/WT melanoma cell lines. Supplemental Fig. S3. Depletion of ErbB3 reduces AKT and ERK1/2 phosphorylation. Supplemental Fig. S4. huHER3-8 reduces AKT phosphorylation. Supplemental Fig. S5. Pertuzumab reduces phosphorylation of AKT and ERK1/2 and inhibits cell growth. Supplemental Fig. S6. MEK inhibitors increase pertuzumab efficacy in xenografts.
Supplementary Figure 6 from Tumor-Induced Pressure in the Bone Microenvironment Causes Osteocytes to Promote the Growth of Prostate Cancer Bone Metastases
Authors: Sottnik Joseph L. , Dai Jinlu , Zhang Honglai , Campbell Brittany , Keller Evan T.
Published: March 2023

Supplementary Figure 6: CCL5 promotes MMP transcription in OCy. MLO-Y4 cells were plated and incubated for 24 hours to produce CM. Recombinant CCL5 was then incubated with MLO-Y4 for 5 hours prior to harvesting of mRNA. Real-time PCR was performed to investigate changes in MMP expression. One-way ANOVA with Bonferroni post-test was used for analysis. All bars represent significant relationships of p>0.05.
Supplementary Figure 5 from Tumor-Induced Pressure in the Bone Microenvironment Causes Osteocytes to Promote the Growth of Prostate Cancer Bone Metastases
Authors: Sottnik Joseph L. , Dai Jinlu , Zhang Honglai , Campbell Brittany , Keller Evan T.
Published: March 2023

Supplementary Figure 5: MMPs promote PCa migration and invasion. A) CM was isolated from MLO-Y4 and PCa cell lines, normalized by total protein concentration, and compared by zymography for MMP expression. Densitometry of zymograph assays is also presented. B) Densitometry of zymograph in Figure 4A of MMP activity. C) mRNA from MLO-Y4 cells exposed to pressure for 24 hours was analyzed by real time PCR for MMP2 and MMP9 expression and normalized to GAPDH. D) MLO-Y4 CM (0 mmHg) was incubated with batimastat to inhibit OCy-derived MMP. CM with batimastat or DMSO control where utilized to determine alterations in PCa migration and invasion. E) PCa cells were incubated in the indicated CM and recombinant MMP2 added at the indicated concentrations. MMP2 concentrations from 40 mmHg CM were recapitulated in 0 mmHg CM through addition of recombinant (exogenous) MMP2. Invasion of PCa towards CM with additional MMP2 was measured. PCR, densitometry, and MMP2 addition experiments were analyzed using One-way ANOVA with Bonferroni post-test. Student's two-tailed t-test was used to analyze MMP inhibition experiments. All bars represent significant relationships of p>0.05.
Supplementary Figure 2 from Tumor-Induced Pressure in the Bone Microenvironment Causes Osteocytes to Promote the Growth of Prostate Cancer Bone Metastases
Authors: Sottnik Joseph L. , Dai Jinlu , Zhang Honglai , Campbell Brittany , Keller Evan T.
Published: March 2023

Supplementary Figure 2: MLO-Y4 CM promotes PCa viability, migration, and invasion. CM was isolated from MLO-Y4 cells. Viability of PCa cells after 24 hour incubation with MLO-Y4 CM as measured by resazurin. Student's two-tailed unpaired t-test was used to assess statistical differences; p<0.05. CM was also used as a chemoattractant in Boyden chamber assays to assess PCa migration and invasion. CM was compared to negative control (RPMI with 0.1% FBS) and positive control (RPMI with 10% FBS) media. One-way ANOVA with Bonferroni post-test used for analysis; bars represent significant differences where p<0.05.
Supplemental Figures S1-S7 from Hepcidin Regulation in Prostate and Its Disruption in Prostate Cancer
Authors: Tesfay Lia , Clausen Kathryn A. , Kim Jin Woo , Hegde Poornima , Wang Xiaohong , Miller Lance D. , Deng Zhiyong , Blanchette Nicole , Arvedson Tara , Miranti Cindy K. , Babitt Jodie L. , Lin Herbert Y. , Peehl Donna M. , Torti Frank M. , Torti Suzy V.
Published: March 2023

Supplemental Figures S1-S7. Hepcidin transcript levels in prostate cells under basal conditions and in response to modulation by signaling effectors (S1); Immunohistochemical detection of hepcidin in prostate tissue (S2); Clonegenic survival of DU145 cells treated with DFO (S3); BMPs induce SMAD signaling in prostate cancer cells (S4); Effect of BMP6 and BMP7 on hepcidin in PC3 and LNCaP prostate cancer cells (S5); Effect of Wnt pathway agonists or antagonists in DU145 cells (S6); Immunohistochemical detection of SOSTDC1 in prostate tissue (S7).
Supplemental Figure Legend from Hepcidin Regulation in Prostate and Its Disruption in Prostate Cancer
Authors: Tesfay Lia , Clausen Kathryn A. , Kim Jin Woo , Hegde Poornima , Wang Xiaohong , Miller Lance D. , Deng Zhiyong , Blanchette Nicole , Arvedson Tara , Miranti Cindy K. , Babitt Jodie L. , Lin Herbert Y. , Peehl Donna M. , Torti Frank M. , Torti Suzy V.
Published: March 2023

Supplemental Figure Legend. Legends to Supplemental Figures S1-S7.
Supplementary Table S3 from Hepatocellular Shuttling and Recirculation of Sorafenib-Glucuronide Is Dependent on Abcc2, Abcc3, and Oatp1a/1b
Authors: Vasilyeva Aksana , Durmus Selvi , Li Lie , Wagenaar Els , Hu Shuiying , Gibson Alice A. , Panetta John C. , Mani Sridhar , Sparreboom Alex , Baker Sharyn D. , Schinkel Alfred H.
Published: March 2023

Sorafenib and SG pharmacokinetic parameters in FVB mice (2-hour study).
Supplementary Methods from Mdm2 and Aurora Kinase A Inhibitors Synergize to Block Melanoma Growth by Driving Apoptosis and Immune Clearance of Tumor Cells
Authors: Vilgelm Anna E. , Pawlikowski Jeff S. , Liu Yan , Hawkins Oriana E. , Davis Tyler A. , Smith Jessica , Weller Kevin P. , Horton Linda W. , McClain Colt M. , Ayers Gregory D. , Turner David C. , Essaka David C. , Stewart Clinton F. , Sosman Jeffrey A. , Kelley Mark C. , Ecsedy Jeffrey A. , Johnston Jeffrey N. , Richmond Ann
Published: March 2023

Supplementary Methods. Description of additional methods and procedures used in the study.
Supplementary Figure S7 from Mdm2 and Aurora Kinase A Inhibitors Synergize to Block Melanoma Growth by Driving Apoptosis and Immune Clearance of Tumor Cells
Authors: Vilgelm Anna E. , Pawlikowski Jeff S. , Liu Yan , Hawkins Oriana E. , Davis Tyler A. , Smith Jessica , Weller Kevin P. , Horton Linda W. , McClain Colt M. , Ayers Gregory D. , Turner David C. , Essaka David C. , Stewart Clinton F. , Sosman Jeffrey A. , Kelley Mark C. , Ecsedy Jeffrey A. , Johnston Jeffrey N. , Richmond Ann
Published: March 2023

Supplementary Figure S7. Results of the flow cytometric analysis of indicated populations of leukocytes in SK-Mel5 tumors grown in BALB/C nu/Foxn1 athymic nude mice.
Supplementary Figure S2 from Hepatocellular Shuttling and Recirculation of Sorafenib-Glucuronide Is Dependent on Abcc2, Abcc3, and Oatp1a/1b
Authors: Vasilyeva Aksana , Durmus Selvi , Li Lie , Wagenaar Els , Hu Shuiying , Gibson Alice A. , Panetta John C. , Mani Sridhar , Sparreboom Alex , Baker Sharyn D. , Schinkel Alfred H.
Published: March 2023

Metabolism and urinary excretion of sorafenib in wildtype and Abcc2(-/-) mice.
Supplementary Figure S5 from Mdm2 and Aurora Kinase A Inhibitors Synergize to Block Melanoma Growth by Driving Apoptosis and Immune Clearance of Tumor Cells
Authors: Vilgelm Anna E. , Pawlikowski Jeff S. , Liu Yan , Hawkins Oriana E. , Davis Tyler A. , Smith Jessica , Weller Kevin P. , Horton Linda W. , McClain Colt M. , Ayers Gregory D. , Turner David C. , Essaka David C. , Stewart Clinton F. , Sosman Jeffrey A. , Kelley Mark C. , Ecsedy Jeffrey A. , Johnston Jeffrey N. , Richmond Ann
Published: March 2023

Supplementary Figure S5. (-)-Nutlin-3 treatment affects tumor vasculature in vivo.
Supplementary Materials and Methods from Tuning Sensitivity of CAR to EGFR Density Limits Recognition of Normal Tissue While Maintaining Potent Antitumor Activity
Authors: Caruso Hillary G. , Hurton Lenka V. , Najjar Amer , Rushworth David , Ang Sonny , Olivares Simon , Mi Tiejuan , Switzer Kirsten , Singh Harjeet , Huls Helen , Lee Dean A. , Heimberger Amy B. , Champlin Richard E. , Cooper Laurence J.N.
Published: March 2023

Supplementary Materials and Methods
Supplementary Figure 5 from Tuning Sensitivity of CAR to EGFR Density Limits Recognition of Normal Tissue While Maintaining Potent Antitumor Activity
Authors: Caruso Hillary G. , Hurton Lenka V. , Najjar Amer , Rushworth David , Ang Sonny , Olivares Simon , Mi Tiejuan , Switzer Kirsten , Singh Harjeet , Huls Helen , Lee Dean A. , Heimberger Amy B. , Champlin Richard E. , Cooper Laurence J.N.
Published: March 2023

Engraftment of intracranial tumor and CAR+ T-cell phenotype prior to administration of T cells
Supplementary Figure 2 from Therapeutic Targeting of the Warburg Effect in Pancreatic Cancer Relies on an Absence of p53 Function
Authors: Rajeshkumar N.V. , Dutta Prasanta , Yabuuchi Shinichi , de Wilde Roeland F. , Martinez Gary V. , Le Anne , Kamphorst Jurre J. , Rabinowitz Joshua D. , Jain Sanjay K. , Hidalgo Manuel , Dang Chi V. , Gillies Robert J. , Maitra Anirban
Published: March 2023

Supplementary Figure 2. H&E and Masson's trichrome staining of PDXs.
Supplementary Figure 1 from Therapeutic Targeting of the Warburg Effect in Pancreatic Cancer Relies on an Absence of p53 Function
Authors: Rajeshkumar N.V. , Dutta Prasanta , Yabuuchi Shinichi , de Wilde Roeland F. , Martinez Gary V. , Le Anne , Kamphorst Jurre J. , Rabinowitz Joshua D. , Jain Sanjay K. , Hidalgo Manuel , Dang Chi V. , Gillies Robert J. , Maitra Anirban
Published: March 2023

Supplementary Figure 1. Baseline TIGAR mRNA expression in tumors.
Supplementary Table S7: Mass spectrometry 13C-glucose tracer lipidomics data from Drug Redeployment to Kill Leukemia and Lymphoma Cells by Disrupting SCD1-Mediated Synthesis of Monounsaturated Fatty Acids
Authors: Southam Andrew D. , Khanim Farhat L. , Hayden Rachel E. , Constantinou Julia K. , Koczula Katarzyna M. , Michell Robert H. , Viant Mark R. , Drayson Mark T. , Bunce Chris M.
Published: March 2023

Mass spectrometry data: free fatty acids and phospholipids from cells that were drug treated in the presence of 13C D-glucose
Supplementary Table S5: Mass spectrometry lipidomics data from Drug Redeployment to Kill Leukemia and Lymphoma Cells by Disrupting SCD1-Mediated Synthesis of Monounsaturated Fatty Acids
Authors: Southam Andrew D. , Khanim Farhat L. , Hayden Rachel E. , Constantinou Julia K. , Koczula Katarzyna M. , Michell Robert H. , Viant Mark R. , Drayson Mark T. , Bunce Chris M.
Published: March 2023

Negative ion mass spectrometry (phospholipid) analysis of lipid extracts from HL60 and K562 cells after 24 hr BaP treatment (0.5 mM bezafibrate, BEZ, and 5 µM medroxyprogesterone acetate, MPA).
Supplementary Figures S1-S5 from Leptin–STAT3–G9a Signaling Promotes Obesity-Mediated Breast Cancer Progression
Authors: Chang Chao-Ching , Wu Meng-Ju , Yang Jer-Yen , Camarillo Ignacio G. , Chang Chun-Ju
Published: March 2023

Supplementary Figures S1-S5. Leptin induces STAT3-G9a interaction and their co-occupancy on targeted gene promoters (S1); Leptin induces EMT and stem cell-like traits via down-regulation of miR-200c (S2); STAT3 and G9a expression is required for OBR induction by leptin (S3); Distinct tumor phenotypes in Western obese animals compared to lean animals (S4); STAT3 activation and OBR overexpression in diet-induced obesity rats (S5).
Supplementary Tables S1 and S2 from Dll4 Blockade in Stromal Cells Mediates Antitumor Effects in Preclinical Models of Ovarian Cancer
Authors: Kuhnert Frank , Chen Guoying , Coetzee Sandra , Thambi Nithya , Hickey Carlos , Shan Jing , Kovalenko Pavel , Noguera-Troise Irene , Smith Eric , Fairhurst Jeanette , Andreev Julian , Kirshner Jessica R. , Papadopoulos Nicholas , Thurston Gavin
Published: March 2023

Supplementary Table S1: Dll4 Ab REGN421 binds human and monkey Dll4 with high affinity Supplementary Table S2: Combined blockade of Dll4 and VEGF signaling results in enhanced inhibition of A2780 ovarian tumors
Figure Legends for Supplementary Figures S1-S12 from Dll4 Blockade in Stromal Cells Mediates Antitumor Effects in Preclinical Models of Ovarian Cancer
Authors: Kuhnert Frank , Chen Guoying , Coetzee Sandra , Thambi Nithya , Hickey Carlos , Shan Jing , Kovalenko Pavel , Noguera-Troise Irene , Smith Eric , Fairhurst Jeanette , Andreev Julian , Kirshner Jessica R. , Papadopoulos Nicholas , Thurston Gavin
Published: March 2023

Legends for Supplementary Figures S1-S12
Supplementary Table S2 from Differentiation and Loss of Malignant Character of Spontaneous Pulmonary Metastases in Patient-Derived Breast Cancer Models
Authors: Bockhorn Jessica , Prat Aleix , Chang Ya-Fang , Liu Xia , Huang Simo , Shang Meng , Nwachukwu Chika , Gomez-Vega Maria J. , Harrell J. Chuck , Olopade Olufunmilayo I. , Perou Charles M. , Liu Huiping
Published: March 2023

Supplementary Table S2. Gene pathway analyses by IPA.
Supplementary figure 5 from Decoy Receptor DcR1 Is Induced in a p50/Bcl3–Dependent Manner and Attenuates the Efficacy of Temozolomide
Authors: Mansour Nassir M. , Bernal Giovanna M. , Wu Longtao , Crawley Clayton D. , Cahill Kirk E. , Voce David J. , Balyasnikova Irina V. , Zhang Wei , Spretz Ruben , Nunez Luis , Larsen Gustavo F. , Weichselbaum Ralph R. , Yamini Bakhtiar
Published: March 2023

Supplementary figure 5. Kaplan-Meier survival curves from the REMBRANDT database stratified based on DCR1 mRNA expression level.
Suppl Table S3 from Differentiation and Loss of Malignant Character of Spontaneous Pulmonary Metastases in Patient-Derived Breast Cancer Models
Authors: Bockhorn Jessica , Prat Aleix , Chang Ya-Fang , Liu Xia , Huang Simo , Shang Meng , Nwachukwu Chika , Gomez-Vega Maria J. , Harrell J. Chuck , Olopade Olufunmilayo I. , Perou Charles M. , Liu Huiping
Published: March 2023

Suppl Table S3. miRNAs differentially in the Met-derived models
Suppl Legends and Methods from Differentiation and Loss of Malignant Character of Spontaneous Pulmonary Metastases in Patient-Derived Breast Cancer Models
Authors: Bockhorn Jessica , Prat Aleix , Chang Ya-Fang , Liu Xia , Huang Simo , Shang Meng , Nwachukwu Chika , Gomez-Vega Maria J. , Harrell J. Chuck , Olopade Olufunmilayo I. , Perou Charles M. , Liu Huiping
Published: March 2023

Suppl Legends and Methods. Supplementary figure/table legends and methods
Supplementary Methods, Figures 1 - 7 from Genetic Regulation of Fate Decisions in Therapeutic T Cells to Enhance Tumor Protection and Memory Formation
Authors: Veliça Pedro , Zech Mathias , Henson Sian , Holler Angelika , Manzo Teresa , Pike Rebecca , Santos e Sousa Pedro , Zhang Lei , Schiedlmeier Bernhard , Pule Martin , Stauss Hans , Chakraverty Ronjon
Published: March 2023

Supplementary methods for flow cytometry and retroviral construct generation. Supplementary Figure 1. Expression of activated caspase-3 in CD8+ T cells overexpressing RHEB or PRAS40. Supplementary Figure 2. Expression of CD25 and CD69 in CD8+ T cells overexpressing RHEB or PRAS40. Supplementary Figure 3. Expression of killer cell lectin-like receptor subfamily G member 1 in CD8+ T cells overexpressing RHEB or PRAS40. Supplementary Figure 4. Recall immunity is impaired in CD8+ T cells overexpressing RHEB or PRAS40. Supplementary Figure 5. GFP induction with Doxycycline in CD8+ T cells transduced with iGFP and iPRAS vectors. Supplementary Figure 6. Levels of phosphorylated S6 after stimulation of CD8+ T cells transduced with pMP71-PRAS40 or pMP71-vector control. Supplementary Figure 7. Frequency of CD8+ T cells expressing shRNAs against mTOR or Raptor in peripheral blood 10 days after injection in tumor-bearing hosts.
Supplementary Figure S1 from JAK Inhibition Impairs NK Cell Function in Myeloproliferative Neoplasms
Authors: Schönberg Kathrin , Rudolph Janna , Vonnahme Maria , Parampalli Yajnanarayana Sowmya , Cornez Isabelle , Hejazi Maryam , Manser Angela R. , Uhrberg Markus , Verbeek Walter , Koschmieder Steffen , Brümmendorf Tim H. , Brossart Peter , Heine Annkristin , Wolf Dominik
Published: March 2023

Supplementary Figure S1. Ruxolitinib does not increase apoptosis rate.
Supplemental Table 1 from Neutrophil Extracellular Traps Accumulate in Peripheral Blood Vessels and Compromise Organ Function in Tumor-Bearing Animals
Authors: Cedervall Jessica , Zhang Yanyu , Huang Hua , Zhang Lei , Femel Julia , Dimberg Anna , Olsson Anna-Karin
Published: March 2023

Supplemental Table 1: Primers used for q-PCR analysis.
Supplementary Figures 1-9 from Pancreatic Cancer Combination Therapy Using a BH3 Mimetic and a Synthetic Tetracycline
Authors: Quinn Bridget A. , Dash Rupesh , Sarkar Siddik , Azab Belal , Bhoopathi Praveen , Das Swadesh K. , Emdad Luni , Wei Jun , Pellecchia Maurizio , Sarkar Devanand , Fisher Paul B.
Published: March 2023

Supplementary Figures 1-9. Sabutoclax has greater efficacy than ABT-737. (S1) Sabutoclax causes a G1-S phase cell cycle arrest. (S2) Pancreatic cancer cells exhibit varying levels of sensitivity to Minocycline. (S3) Sabutoclax and Minocycline induce cytotoxicity in PANC-1 cells that is reversed with zVAD. (S4) Sabutoclax and Minocycline show synergy. Combination index (CI) values for the combination of Sabutoclax and Minocycline in MIA PaCa-2 cells. (S5) The cytotoxicity induced by Sabutoclax and Minocycline is caspase-dependent and dependent upon loss of Stat3 activation. (S6) Sabutoclax and Minocycline reduce tumor growth in a subcutaneous xenograft model of pancreatic cancer. (S7) Tumors from Pdx-1-Cre/K-rasLSL-G12D/p53flox/wt and Pdx-1-Cre/K-rasLSL-G12D/p53flox/flox mice overexpress Mcl-1 and show sensitivity to Sabutoclax and Minocycline. (S8) Tumors from KPC (Pdx-1-Cre/K-rasLSL-G12D/p53flox/flox )mice treated with Sabutoclax and Minocycline show decreased Stat3 activation. (S9)
Supplemental Figure 2 from Neutrophil Extracellular Traps Accumulate in Peripheral Blood Vessels and Compromise Organ Function in Tumor-Bearing Animals
Authors: Cedervall Jessica , Zhang Yanyu , Huang Hua , Zhang Lei , Femel Julia , Dimberg Anna , Olsson Anna-Karin
Published: March 2023

Supplemental Figure 2: Neutrophil depletion restores vascular function in kidneys from RIP1-Tag2 mice.
Supplementary Figure Legends 1-9 from Pancreatic Cancer Combination Therapy Using a BH3 Mimetic and a Synthetic Tetracycline
Authors: Quinn Bridget A. , Dash Rupesh , Sarkar Siddik , Azab Belal , Bhoopathi Praveen , Das Swadesh K. , Emdad Luni , Wei Jun , Pellecchia Maurizio , Sarkar Devanand , Fisher Paul B.
Published: March 2023

Supplementary Figure Legends 1-9
Supplementary Methods from HSP90 Supports Tumor Growth and Angiogenesis through PRKD2 Protein Stabilization
Authors: Azoitei Ninel , Diepold Kristina , Brunner Cornelia , Rouhi Arefeh , Genze Felicitas , Becher Alexander , Kestler Hans , van Lint Johan , Chiosis Gabriela , Koren John , Fröhling Stefan , Scholl Claudia , Seufferlein Thomas
Published: March 2023

Supplementary Methods. Description of additional methods and procedures used in the study.
Supplementary Fig. S3 from Development of Lung Adenocarcinomas with Exclusive Dependence on Oncogene Fusions
Authors: Saito Motonobu , Shimada Yoko , Shiraishi Kouya , Sakamoto Hiromi , Tsuta Koji , Totsuka Hirohiko , Chiku Suenori , Ichikawa Hitoshi , Kato Mamoru , Watanabe Shun-ichi , Yoshida Teruhiko , Yokota Jun , Kohno Takashi
Published: March 2023

Supplementary Fig. S3. Gene mutation frequency by driver aberration
Supplementary Figure 6 from Tumor-Promoting Desmoplasia Is Disrupted by Depleting FAP-Expressing Stromal Cells
Authors: Lo Albert , Wang Liang-Chuan S. , Scholler John , Monslow James , Avery Diana , Newick Kheng , O'Brien Shaun , Evans Rebecca A. , Bajor David J. , Clendenin Cynthia , Durham Amy C. , Buza Elizabeth L. , Vonderheide Robert H. , June Carl H. , Albelda Steven M. , Puré Ellen
Published: March 2023

Alteration of tumor structure by FAP-CAR T cells in murine PDAs.
Supplementary Table and Figure Legend from Combined Label-Free Quantitative Proteomics and microRNA Expression Analysis of Breast Cancer Unravel Molecular Differences with Clinical Implications
Authors: Gámez-Pozo Angelo , Berges-Soria Julia , Arevalillo Jorge M. , Nanni Paolo , López-Vacas Rocío , Navarro Hilario , Grossmann Jonas , Castaneda Carlos A. , Main Paloma , Díaz-Almirón Mariana , Espinosa Enrique , Ciruelos Eva , Fresno Vara Juan Ángel
Published: March 2023

Supplementary Table and Figure Legend. Legends for Supplementary Tables S1-S8 and Supplementary Figures S1-S2.
Supplementary Figure 2 from Tumor-Promoting Desmoplasia Is Disrupted by Depleting FAP-Expressing Stromal Cells
Authors: Lo Albert , Wang Liang-Chuan S. , Scholler John , Monslow James , Avery Diana , Newick Kheng , O'Brien Shaun , Evans Rebecca A. , Bajor David J. , Clendenin Cynthia , Durham Amy C. , Buza Elizabeth L. , Vonderheide Robert H. , June Carl H. , Albelda Steven M. , Puré Ellen
Published: March 2023

The adaptive immune response plays a critical role in FAP-CAR T cell-mediated anti-tumor activity in immunogenic AE17.OVA tumors.
Supplementary Table S5 from Combined Label-Free Quantitative Proteomics and microRNA Expression Analysis of Breast Cancer Unravel Molecular Differences with Clinical Implications
Authors: Gámez-Pozo Angelo , Berges-Soria Julia , Arevalillo Jorge M. , Nanni Paolo , López-Vacas Rocío , Navarro Hilario , Grossmann Jonas , Castaneda Carlos A. , Main Paloma , Díaz-Almirón Mariana , Espinosa Enrique , Ciruelos Eva , Fresno Vara Juan Ángel
Published: March 2023

Supplementary Table S5. MicroRNA TaqMan assay IDs.
Supplementary Figure S1 from Combined Label-Free Quantitative Proteomics and microRNA Expression Analysis of Breast Cancer Unravel Molecular Differences with Clinical Implications
Authors: Gámez-Pozo Angelo , Berges-Soria Julia , Arevalillo Jorge M. , Nanni Paolo , López-Vacas Rocío , Navarro Hilario , Grossmann Jonas , Castaneda Carlos A. , Main Paloma , Díaz-Almirón Mariana , Espinosa Enrique , Ciruelos Eva , Fresno Vara Juan Ángel
Published: March 2023

Supplementary Figure S1. Correlation between Metabolism B activity and miR-449a expression values.
Supplementary Tables S1-S3 from Chronic Inflammation Induces a Novel Epigenetic Program That Is Conserved in Intestinal Adenomas and in Colorectal Cancer
Authors: Abu-Remaileh Monther , Bender Sebastian , Raddatz Günter , Ansari Ihab , Cohen Daphne , Gutekunst Julian , Musch Tanja , Linhart Heinz , Breiling Achim , Pikarsky Eli , Bergman Yehudit , Lyko Frank
Published: March 2023

Supplementary Tables S1-S3. Expression levels of selected genes (S1); Downregulated genes associated with hypermethylated DMVs (S2); Validation of WGBS data by 454 bisulfite sequencing (S3).
Supplemental Methods and References from Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy
Authors: Picaud Sarah , Fedorov Oleg , Thanasopoulou Angeliki , Leonards Katharina , Jones Katherine , Meier Julia , Olzscha Heidi , Monteiro Octovia , Martin Sarah , Philpott Martin , Tumber Anthony , Filippakopoulos Panagis , Yapp Clarence , Wells Christopher , Che Ka Hing , Bannister Andrew , Robson Samuel , Kumar Umesh , Parr Nigel , Lee Kevin , Lugo Dave , Jeffrey Philip , Taylor Simon , Vecellio Matteo L. , Bountra Chas , Brennan Paul E. , O'Mahony Alison , Velichko Sharlene , Müller Susanne , Hay Duncan , Daniels Danette L. , Urh Marjeta , La Thangue Nicholas B. , Kouzarides Tony , Prinjha Rab , Schwaller Jürg , Knapp Stefan
Published: March 2023

Description of additional methods and procedures used in the study. Also includes Supplemental References.
Supplementary Figure S3 from Ormeloxifene Suppresses Desmoplasia and Enhances Sensitivity of Gemcitabine in Pancreatic Cancer
Authors: Khan Sheema , Ebeling Mara C. , Chauhan Neeraj , Thompson Paul A. , Gara Rishi K. , Ganju Aditya , Yallapu Murali M. , Behrman Stephen W. , Zhao Haotian , Zafar Nadeem , Singh Man Mohan , Jaggi Meena , Chauhan Subhash C.
Published: March 2023

Supplementary Figure S3. ORM targets Sonic hedgehog signaling and inhibits NFĸB and Gli-1 transcriptional activity in PDAC cells.
Supplementary Figure S1 from Identification of Rare High-Avidity, Tumor-Reactive CD8+ T Cells by Monomeric TCR–Ligand Off-Rates Measurements on Living Cells
Authors: Hebeisen Michael , Schmidt Julien , Guillaume Philippe , Baumgaertner Petra , Speiser Daniel E. , Luescher Immanuel , Rufer Nathalie
Published: March 2023

Supplementary Figure S1. Determination of TCR-ligand off-rates on a panel of CD8+ T cells engineered with TCRs of incremental affinities against the A2/NY-ESO-1 tumor antigen.
supplementary figure 5 from Enhanced MET Translation and Signaling Sustains K-Ras–Driven Proliferation under Anchorage-Independent Growth Conditions
Authors: Fujita-Sato Saori , Galeas Jacqueline , Truitt Morgan , Pitt Cameron , Urisman Anatoly , Bandyopadhyay Sourav , Ruggero Davide , McCormick Frank
Published: March 2023

supplementary figure 5. Activation of Met signaling rescues K-Ras knock down-mediated growth suppression.
Supplemental Figure 1 - 12 from The Endogenous Cell-Fate Factor Dachshund Restrains Prostate Epithelial Cell Migration via Repression of Cytokine Secretion via a CXCL Signaling Module
Authors: Chen Ke , Wu Kongming , Jiao Xuanmao , Wang Liping , Ju Xiaoming , Wang Min , Di Sante Gabriele , Xu Shaohua , Wang Qiong , Li Kevin , Sun Xin , Xu Congwen , Li Zhiping , Casimiro Mathew C. , Ertel Adam , Addya Sankar , McCue Peter A. , Lisanti Michael P. , Wang Chenguang , Davis Richard J. , Mardon Graeme , Pestell Richard G.
Published: March 2023

Supplemental Figure 1. Quantitation and statistical evaluation of the microarray data for Fig. 1A and Fig. 2H, I. Supplemental Figure 2. Somatic excision of Dach1 in prostate epithelial cells. Supplemental Figure 3. Transgenic deletion of Dach1 in the prostate epithelial cells enhances cellular proliferation and reduces cellular apoptosis. Supplemental Figure 4. Prostate specific expression of Dach1 enhances cyclin D1 and cyclin A1. Supplemental Figure 5. Quantitation and statistical evaluation of the microarray data for Fig. 3F and Fig. 4A, B. Supplemental Figure 6. ChIP analysis of cyclin A2 and cyclin E1 promoter regions. Supplemental Figure 7. Endogenous Dach1 is a key restraint of prostate cytokine production. Supplemental Figure 8. Time lapse microscopy of Dach1-/- vs. Dach1+/+ anterior prostate epithelial cells. Supplemental Figure 9. Transgenic deletion of Dach1 in prostate epithelial cells increases IL-6 and IL-8 expression.Supplemental Figure 10. Time lapse microscopy of Dach1+/+ or Dach1-/- ventral prostate epithelial cells. Supplemental Figure 11. The Expression of DACH1 in PC3 cells. Supplemental Figure 12. The relationship between DACH1 and IL-6, IL-8 in metastatic prostate cancer.
supplementary figure 1 from Enhanced MET Translation and Signaling Sustains K-Ras–Driven Proliferation under Anchorage-Independent Growth Conditions
Authors: Fujita-Sato Saori , Galeas Jacqueline , Truitt Morgan , Pitt Cameron , Urisman Anatoly , Bandyopadhyay Sourav , Ruggero Davide , McCormick Frank
Published: March 2023

supplementary figure 1. Dependence of K-Ras mutant cells on K-Ras in monolayer and anchorage independent culture conditions.
Supplementary Methods, Figures 1 - 2, Tables 1 - 4 from Four-in-One Antibodies Have Superior Cancer Inhibitory Activity against EGFR, HER2, HER3, and VEGF through Disruption of HER/MET Crosstalk
Authors: Hu Shi , Fu Wenyan , Xu Weihao , Yang Yang , Cruz Melissa , Berezov Sandra D. , Jorissen Daniel , Takeda Hiroaki , Zhu Wangdong
Published: March 2023

Supplementary Materials and Methods: Designed antibodies, Expression and Purification, Affinity Measurement, ELISA, Pharmacokinetics, Generation of drug-resistant cell line in vitro, Generation of drug-resistant cell line In vivo, Primers for real-time quantitative PCR, siRNA transfection, Real-time polymerase chain reaction (PCR), Determination of receptor level. Figure S1. DVD-Ig like, tetra-specific, tetravalent antibody CRTB6 binds to antigens. Figure S2. Characterization of Antitumor Activity of bispecific antibodies in vitro and in vivo. Table S1. Selected analytical and affinity data for the parental and four-in-one antibodies. Table S2. Pharmacokinetic parameters of recombinant antibodies in mice. Table S3. Selected analytical and affinity data for the investigated compounds. Table S4. Comparison of cancer cell lines for surface receptor level.
Supplemental Figures S1-S10 from Aberrant Expression of MHC Class II in Melanoma Attracts Inflammatory Tumor-Specific CD4+ T- Cells, Which Dampen CD8+ T-cell Antitumor Reactivity
Authors: Donia Marco , Andersen Rikke , Kjeldsen Julie W. , Fagone Paolo , Munir Shamaila , Nicoletti Ferdinando , Andersen Mads Hald , thor Straten Per , Svane Inge Marie
Published: March 2023

Characteristics of CD8 TILs from patients with high or no/low CD4+ T cell responses (S1); Up-regulation of MHC class I and II expression after exposure to IFN-γ (S2); Expression of TNF of CD4+ and CD8+ T cells (S3); SPICE plots displaying all possible combination of T cell functions (S4); Effects of in vitro expansion on T-cell functional patterns (S5); Effects of in vitro expansion on T-cell functional patterns (S6); Effects of TNF on tumor recognition of MART-1 specific CD8+ TILs (S7); Effects of cytokines on tumor recognition of CD8+ TILs (S8); Effects of TNF on gene expression of melanoma cells (S9); LDH levels and Survival (S10).
Supplementary Methods and Table 1 from Mechanistic Rationale to Target PTEN-Deficient Tumor Cells with Inhibitors of the DNA Damage Response Kinase ATM
Authors: McCabe Nuala , Hanna Conor , Walker Steven M. , Gonda David , Li Jie , Wikstrom Katarina , Savage Kienan I. , Butterworth Karl T. , Chen Clark , Harkin D. Paul , Prise Kevin M. , Kennedy Richard D.
Published: March 2023

Supplementary Methods and Table 1. Supplementary Table 1: siRNA target genes
Supplementary Table S1 from ADAPT, a Novel Scaffold Protein-Based Probe for Radionuclide Imaging of Molecular Targets That Are Expressed in Disseminated Cancers
Authors: Garousi Javad , Lindbo Sarah , Nilvebrant Johan , Åstrand Mikael , Buijs Jos , Sandström Mattias , Honarvar Hadis , Orlova Anna , Tolmachev Vladimir , Hober Sophia
Published: March 2023

Affinity constants of DOTA-C-(HE)3-ADAPT6 and H6-ADAPT6.
Supplementary Figures S1-3, Tables S1-2 from Decreased Ferroportin Promotes Myeloma Cell Growth and Osteoclast Differentiation
Authors: Gu Zhimin , Wang He , Xia Jiliang , Yang Ye , Jin Zhendong , Xu Hongwei , Shi Jumei , De Domenico Ivana , Tricot Guido , Zhan Fenghuang
Published: March 2023

Supplementary Figures S1-3, Tables S1-2. Figure S.1. FPN1 downregulates STAT3-MCL-1 signaling, related to Figure 2 and 4. Figure S.2. FPN1 is downregulated in the initial phase of osteoclastogenesis, related to Figure 5. Figure S.3. High FPN1 suppresses myeloma cell-induced osteoclast differentiation, related to Figure 6. Table S1: Genes related to iron metabolism Table S2: primers for qPCR
Supplementary Table S2 from Genetic Deletion of AEG-1 Prevents Hepatocarcinogenesis
Authors: Robertson Chadia L. , Srivastava Jyoti , Siddiq Ayesha , Gredler Rachel , Emdad Luni , Rajasekaran Devaraja , Akiel Maaged , Shen Xue-Ning , Guo Chunqing , Giashuddin Shah , Wang Xiang-Yang , Ghosh Shobha , Subler Mark A. , Windle Jolene J. , Fisher Paul B. , Sarkar Devanand
Published: March 2023

Complete blood count of peripheral blood in WT and AEG-1KO mice.
Supplemental Table and Figure Legends from Genetic Deletion of AEG-1 Prevents Hepatocarcinogenesis
Authors: Robertson Chadia L. , Srivastava Jyoti , Siddiq Ayesha , Gredler Rachel , Emdad Luni , Rajasekaran Devaraja , Akiel Maaged , Shen Xue-Ning , Guo Chunqing , Giashuddin Shah , Wang Xiang-Yang , Ghosh Shobha , Subler Mark A. , Windle Jolene J. , Fisher Paul B. , Sarkar Devanand
Published: March 2023

Legends for Supplementary Tables S1-S7 and Supplementary Figures S1-S5.
Supplementary Methods and References from Usp28 Counteracts Fbw7 in Intestinal Homeostasis and Cancer
Authors: Diefenbacher Markus E. , Chakraborty Atanu , Blake Sophia M. , Mitter Richard , Popov Nikita , Eilers Martin , Behrens Axel
Published: March 2023

Supplementary Methods and References. Description of additional methods and procedures used in the study. Also includes Supplementary References.
Supplementary Figure 1 from Gain of Glucose-Independent Growth upon Metastasis of Breast Cancer Cells to the Brain
Authors: Chen Jinyu , Lee Ho-Jeong , Wu Xuefeng , Huo Lei , Kim Sun-Jin , Xu Lei , Wang Yan , He Junqing , Bollu Lakshmi R. , Gao Guang , Su Fei , Briggs James , Liu Xiaojing , Melman Tamar , Asara John M. , Fidler Isaiah J. , Cantley Lewis C. , Locasale Jason W. , Weihua Zhang
Published: March 2023

Supplementary Figure S1. Western blot characterization of antibodies against BCKDH-E1 and BCKDH-pSer-E1
Supplemental Figures S1-S2 from Identification and Characterization of Tyrosine Kinase Nonreceptor 2 Mutations in Leukemia through Integration of Kinase Inhibitor Screening and Genomic Analysis
Authors: Maxson Julia E. , Abel Melissa L. , Wang Jinhua , Deng Xianming , Reckel Sina , Luty Samuel B. , Sun Huahang , Gorenstein Julie , Hughes Seamus B. , Bottomly Daniel , Wilmot Beth , McWeeney Shannon K. , Radich Jerald , Hantschel Oliver , Middleton Richard E. , Gray Nathanael S. , Druker Brian J. , Tyner Jeffrey W.
Published: March 2023

Hitwalker diagram from CMML patient sample 10-210 (S1); EGFR binding domain of Tnk2 (S2).