bluuebunny/crossref_metadata_2025 huggingface dataset:
Impact of Pyrazinamide Usage on Serious Adverse Events in Elderly Tuberculosis Patients: A Multicenter Cohort Study
Authors: Yoon Joon Young , Kim Tae-Ok , Kim Ju Sang , Kim Hyung Woo , Lee Eung Gu , Jeong Sung Soo , Oh Jee Youn , Kim Jin Woo , Lee Sang Haak , Kim Seunghoon , Kim Sun-Hyung , Park Yeonhee , Min Jinsoo , Kwon Yong-Soo
Published: March 2024

Background Pyrazinamide (PZA) usage has been associated with adverse drug reactions, prompting its avoidance in treating elderly tuberculosis (TB) patients. This study aims to examine whether the administration of PZA is associated with poor outcomes during TB treatment among elderly individuals. Methods A retrospective analysis was undertaken on data collected from a prospective cohort conducted between July 2019 and June 2023, which involved tuberculosis patients from 18 institutions across the Republic Korea. The study aimed to assess the impact of PZA on the incidence of serious adverse events (SAEs), medication interruptions, and becoming lost to follow-up (LTFU) during standard short courses of TB treatment in elderly (≥ 65 years old) patients. Results PZA was administered to 356 of 390 elderly patients (91.3%), and 98 of the 390 (25.1%) experienced SAEs. Treatment success was significantly lower in patients not treated with PZA compared to those who received PZA (64.7% vs 89.9%, p < 0.001). The incidence of SAEs, medication interruption, or LTFU was higher in patients not given PZA compared those who received PZA (52.9% vs. 27.2%, p = 0.002). A multivariate logistic regression analysis, factoring in covariates such as age, comorbidities, and baseline laboratory data, revealed that PZA was not a risk factor for SAEs, medication interruption, or LTFU in TB treatment (odds ratio [OR] 0.457, 95% confidence interval [CI] 0.201–1.041). Conclusion Treating elderly TB patients with PZA did not increase the incidence of SAEs, medication interruptions, or LTFU during the standard short course of TB treatment. Therefore, considering its potential advantages, incorporating PZA into the treatment regimen for elderly TB patients may be advisable.
Experimental Study on Bearing Characteristics of Single Piles of Different Lengths in Heterogeneous Layered Foundation
Authors: WANG Zhengzhen , HUANG Lei , DAI Guoliang , CAO Chengming , Zhu Wentao
Published: March 2024

In order to study the vertical bearing characteristics of bored piles with different lengths in heterogeneous layered foundation, two single piles with different lengths in layered foundation were tested using BOFDA technique and anchor pile method static load test relying on the pile testing project of Lanzhou Zhongchuan International Airport Phase III expansion project. The pile top settlement, pile axial force, pile side friction resistance and pile-soil relative displacement under vertical load were measured and analyzed. On the other hand, the measured limit lateral resistance value was compared with the recommended value in the geological survey report, and the relationship between pile end resistance and pile end displacement under the influence of sediment was analyzed by using the three-fold line model. The results can provide reference for the design and testing of bored pile in heterogeneous layered foundation.
Optimizing Concrete Performance through Metakaolin and Flyash Incorporation: A Critical Appraisal of Regression Modeling and Design Code Applicability
Authors: MM Saravanan , Ayyadurai Ananthakumar , P Sasikumar
Published: March 2024

An investigation into the use of metakaolin (MK) and fly ash (FA) as partial cement replacements in concrete was conducted to enhance the sustainability of the construction industry. The MK and FA were incorporated into the concrete mix design by weight, replacing a portion of the portland cement content. The replacement percentages varied in two sets: 5%, 7.5%, 10%, 12.5%, and 15% for MK; and 5%, 10%, 15%, 20%, and 25% for FA. Workability of the fresh concrete was evaluated using the slump cone test to identify the optimal replacement level. Subsequently, the mechanical properties of the hardened concrete were investigated using compressive strength (CS), split tensile strength (STS), flexural strength (FS), modulus of elasticity (MoE). The results revealed that incorporating MK improved the mechanical properties: CS increased by 12.06%, STS by 16.84%, and FS by 15.42% compared to the control mix. In comparison, FA substitution resulted in a slightly lower increase: CS by 9.72%, STS by 12.84%, and FS by 8.57%. The study concluded that MK exhibited a superior performance in enhancing the strength properties of concrete compared to FA. Additionally, linear regression analysis was employed to establish correlations between the experimentally determined strength properties and the mix design parameters. This analysis demonstrated a strong correlation between the predicted and experimental values, making it a valuable tool for future concrete mix design optimization.
A Container Optimal Matching Deployment Algorithm based on CN-Graph for Mobile Edge Computing
Authors: Rao Huanle , Chen Sheng , Du Yuxuan , Xu Xiaobin , Chen Haodong , Jia Gangyong
Published: March 2024

The deployment of increasingly diverse services on edge devices is becoming increasingly prevalent. Efficiently deploying functionally heterogeneous services to resource heterogeneous edge nodes while achieving superior user experience is a challenge that every edge system must address. In this paper, we propose a Container-Node Graph (CN-Graph) based container optimal matching deployment algorithm, Edge Kuhn-Munkres Algorithm (EKM) Based on Container-Node Graph, designed for heterogeneous environment to optimize systemperformance. Initially, containers are categorized by functional labels, followed by construction of a CN-Graph model based on the relationship between containers and nodes. Finally, the container deployment problem is transformed into a weighted bipartite graph optimal matching problem. In comparison with the mainstream container deployment algorithms, Swarm, Kubernetes, and the recently emerged ECSched-dp algorithm, the EKM algorithm demonstrates the ability to effectively enhance the average runtime performance of containers to 3.74 times, 4.10 times, and 2.39 times, respectively.
The effects of standardized intravenous Treprostinil in pulmonary arterial hypertension patients after total cavo-pulmonary connection procedure
Authors: Wang Xiaofeng , Wang Shilin , Shen Ruihuan , Lu Zhongyuan , Wang Xu
Published: March 2024

Objective
Total cavo-pulmonary connection (TCPC) is a palliative treatment for single ventricular malformations. For high-risk patients (preoperative mean pulmonary arterial pressure, mPAP > 15 mmHg), between the inhaled and oral targeted medications, the application of intravenous Treprostinil as a bridge therapy to achieve "seamless" management is core postoperative treatment. This study intends to explore the effect of different administration regimens on early postoperative recovery.
Methods
This was a retrospective cohort study. High-risk pediatric patients (age ≤ 14 years) who underwent TCPC procedure in Fu Wai Hospital from 2015 to 2022 were included. Since the regimen of Treprostinil was standardized in our center in 2021, the patients in 2020 and before were included in group 1, patients in 2021 and 2022 were included in group 2. The hemodynamic parameters were compared before and after the maintenance dose of Treprostinil. The differences of demographic characteristics, surgical data and postoperative recovery were compared between the two groups.
Results
A total of 51 pediatric patients was included. The group 1 included 35 patients who received Treprostinil at 1–3 post-operative days and an average dose of 12 ± 4 ng/(kg·min). The group 2 included 16 patients who received Treprostinil within postoperative 1 day and an average dose of 22 ± 7 ng/(kg·min). There were no significant differences between the two groups in terms of age, weight, preoperative percutaneous oxygen saturation and mPAP, heterotaxia syndrome, TCPC procedure type, other concurrent procedure, cardiopulmonary bypass time and aortic cross clamp proportion (p > 0.05). After 24 hours of Treprostinil treatment, the mPAP in group 1 reduced from 17 ± 3 mmHg to 15 ± 2mmHg (p < 0.001), and in group 2 from 17 ± 2 mmHg to 14 ± 2mmHg (p < 0.001), with no difference between groups. In the postoperative recovery, patients in Group 2 exhibited a reduced duration of mechanical ventilation, 19 (11, 25) hours vs 69 (23, 189) hours, p = 0.001; a shorter stay in the ICU, 8 (6,12) days vs 16 (9,26) days, p = 0.006; and a shorter postoperative length of stay, 27 (17,55) days vs 39 (29,58) days, p = 0.032. Patients in group 2 also exhibited a lower incidence of thromboembolic events, 0 (0/26) vs 26% (9/35), p = 0.043; and the need for renal replacement therapy, 0 (0/26) vs 31% (11/35), p = 0.011.
Conclusion
After TCPC procedure, the standardized application of Treprostinil can improve the postoperative recovery, reduce the incidence of important complications and benefit the early postoperative recovery.
Towards the Prediction of Drug Solubility in Binary Solvent Mixtures at Various Temperatures Using Machine Learning
Authors: Bao Zeqing , Tom Gary , Cheng Austin , Aspuru-Guzik Alán , Allen Christine
Published: March 2024

Drug solubility plays an important role in the drug development process. Traditional methods for measuring solubility involve saturating a solvent with the drug and determining the drug concentration thereafter. However, these techniques are tedious and challenging to employ when dealing with expensive drugs or those available in small quantities. To address this, researchers have begun to leverage machine learning (ML) as an alternative approach. ML offers a data-driven strategy that enables the training of models on existing datasets to predict unmeasured solubility. Nonetheless, the majority of existing ML research has focused on the predictions of aqueous solubility and/or solubility at specific temperatures. This restricts the application of these models in pharmaceutical development which often requires insights into drug solubility across various solvents, solvent mixtures, and temperature conditions. To bridge this gap, we compiled an extensive dataset including solubility of small molecules measured in a range of binary solvent mixtures under various temperatures. We trained models on this dataset and subsequently optimized through Bayesian optimization to identify the models and model configurations that deliver optimal performance. The chosen top-performing models were further validated through a prospective study. The results demonstrated the potential of these developed ML models to predict drug solubility, especially for drugs whose features closely align with the small molecules within the dataset. To support future research and facilitate advancements in the field, we have made the dataset and the codes openly available.
Data-Independent Acquisition-Based Mass Spectrometry (DIA-MS) Reveals Exosome Yes1 derived from cancer cells promotes osteosarcoma tumorigenesis via MAPK pathway
Authors: Li Zihua , Chen Qingjing , Zhang Yi , Ye Zhanhui , Song Yixian , Zhang Yiwei , Gu Chenzheng , Tan Jia , Yang Yunfeng , Shang Anquan
Published: March 2024

Background
Osteosarcoma (OS) stands as the predominant primary bone tumor impacting children and young adults. Exosomes, vital for cellular communication, emerge as promising markers for diagnosing and prognosticating tumors. While few proteomic studies have delved into osteosarcoma's exosomal protein secretion, examining the differences in exosomal proteomes from OS cells can unveil insights into bone tumor development and spread.
Methods This investigation employed Data-Independent Acquisition-Based Mass Spectrometry to analyze the exosomal proteomes of osteoblast and osteosarcoma cells. Exosomal YES1, belonging to the proto-oncogene tyrosine-protein kinase Src family kinases and linked with cancer genesis, tumor environments, and patient survival across various cancers, especially osteosarcoma, was a focal point. The study's experimental approach included in vitro functional assays (Edu, wound healing, transwell assays, flow cytometry) and in vivo experiments to assess the effects of exosomes on the malignant traits of OS cells. Immunohistochemistry was used to compare YES1 expression in human osteosarcoma tissues against normal tissues, complemented by bioinformatic analyses correlating YES1 expression levels with patient survival and prognosis.
Results The research found that exosomal YES1 from osteosarcoma cells is integral to the immune microenvironment and cancer-promoting activities in OS through the MAPK pathway. It was observed that YES1 expression was notably higher in osteosarcoma tissues compared to normal ones, aligning with bioinformatics findings that linked elevated YES1 expression with lower overall survival rates and poorer prognoses in patients.
Conclusions This study highlighted the critical role of osteosarcoma-derived exosomal YES1 in tumor immunology and oncogenesis via the MAPK pathway, presenting new perspectives on the function of exosomal proteins in osteosarcoma tumorigenesis. It also suggests the potential of exosomal YES1 as a biomarker for osteosarcoma therapy, emphasizing its importance in understanding tumor behavior and improving patient outcomes.
A Qualitative Exploration of Providers’ Approaches to Relational Harm Reduction in HIV Primary Care Settings
Authors: Kay Emma Sophia , Creasy Stephanie , Townsend Jessica , Hawk Mary
Published: March 2024

Background
Structural harm reduction is an approach to care for people who use drugs (PWUD) that incorporates services and resources (e.g., naloxone, sterile syringes). As conceptualized in our previous research, harm reduction is also “relational,” encompassing a patient-provider relationship that is non-judgmental and respectful of patients’ autonomy. Little is known about providers’ knowledge or attitudes towards harm reduction beyond structural strategies, whose availability and legality vary across geographical settings. To operationalize how relational harm reduction is both characterized and employed in HIV care settings, where nearly half of patients have a diagnosed substance use disorder, we qualitatively explored providers’ knowledge of and use of harm reduction via individual in-depth interviews.
Methods
Our study sample included three HIV clinics, one in Birmingham, Alabama (AL) and two in Pittsburgh, Pennsylvania (PA). We conducted individual interviews with n = 23 providers via Zoom, using a semi-structured interview guide to probe for questions around providers’ attitudes towards and experiences with providing care to PWH who use drugs and their knowledge of and attitudes towards relational and structural harm reduction. Data was analyzed in Dedoose using thematic analysis.
Results
Qualitative analyses revealed three primary themes, including Relational Harm Reduction in Practice, Not Harm Reduction, No Knowledge of Harm Reduction, and Harm Reduction Training. Nearly all providers (n = 19, 83%) described a patient interaction or expressed a sentiment that corresponded with the principles of relational harm reduction. Yet, over half of participants (n = 14, 61%) used language to describe PWH who use drugs that was stigmatizing or described an interaction that was antithetical to the principles of relational harm reduction. Five providers, all from Birmingham, were unaware of the term ‘harm reduction.’ Few providers had any harm reduction training.
Conclusion
Our findings suggest that relational harm reduction in HIV care settings is practiced along a continuum, and that a range of behaviors exist even within individual providers (e.g., used stigmatizing terms such as “addict” but also described patient interactions that reflected patients’ autonomy). Given that harm reduction is typically described as a structural approach, a broader definition of harm reduction that is not dependent on policy-dependent resources is needed.
Unraveling the Cellular and Molecular Landscape of IgA Nephropathy through Single-Cell RNA Sequencing Analysis
Authors: Hou Juan , Xu Bin , Zhu Jingjing , Yuan Ye , Zhou Fanglin , Xu Zhongxiu , Liu Qingqing , Shi Juanjuan , Xu Wenhan , Cui Jie , Ye Xintong , Wu Ziwei , Wang Wei
Published: March 2024

Objective
This study leverages public database resources to investigate the cellular and molecular mechanisms in IgA nephropathy, a major contributor to chronic kidney disease, using single-cell RNA sequencing (scRNA-seq) analysis.
Methods
Publicly available scRNA-seq datasets of kidney biopsy samples from IgA nephropathy patients and healthy individuals were analyzed. We conducted a detailed transcriptomic profiling of individual cells to identify distinct cell populations and their roles in IgA nephropathy. The study focused on delineating the inflammatory microenvironment and assessing the functional status of critical cell types, notably podocytes and fibroblasts.
Results
Transcriptomic analysis revealed significant alterations across various cell types in the context of IgA nephropathy. Podocytes displayed substantial functional impairment, evident from altered gene expression related to glomerular filtration and structural maintenance. In parallel, renal fibroblasts were activated, exhibiting a transcriptional profile indicative of fibrosis. These findings highlight a pathogenic microenvironment dominated by inflammation and fibrosis, which is central to the progression of IgA nephropathy. The study also shed light on potential molecular targets and pathways that may be implicated in the disease's pathogenesis.
Conclusion
Employing data from public databases, this study underscores the power of single-cell technologies in dissecting the complex pathophysiology of IgA nephropathy. The insights gained into cell-specific transcriptomic changes offer novel perspectives on the disease mechanisms and suggest potential avenues for therapeutic development. This approach marks a significant step in advancing our understanding of IgA nephropathy and highlights the potential of public datasets in facilitating biomedical research, especially in the realm of personalized medicine.
Intuition Brain Health Study: a smartphone- and smartwatch-based virtual, observational study using multimodal mobile sensing to classify and detect mild cognitive impairment
Authors: Butler Paul , Au Rhoda , Becker Andrew , Bianchi Matt , Brown Roland , Cosne Gautier , Demircioglu Gizem , Erkkinen Michael , Gabelle Audrey , Hobbs Matt , Hughes Richard , Juraver Adrien , Langbaum Jessica , Lenyoun Hanson , Lingler Jennifer , Penalver-Andres Joaquin , Pham Hung , Porsteinsson Anton , Price Pamela , Quiroz Yakeel , Roggen Daniel , Saha-Chaudhuri Paramita , Scotland Alf , Sha Sharon , Sliwinski Marty , Song Han , Yang Jenny , Belachew Shibeshih
Published: March 2024

Smart devices are utilized by billions worldwide. The ubiquity of consumer-grade smart devices provides opportunities to robustly capture real-world cognition. Intuition (NCT05058950) was a virtual, observational study that enrolled 23,004 U.S. adults in 18-months collecting longitudinal multimodal data via iPhone and Apple Watch using a custom research application that captured routine device use, self-reported health information, and cognitive assessments. The study objectives were to classify mild cognitive impairment, characterize cognitive trajectories, and develop tools to detect and track cognitive health at scale. The study addresses sources of bias in current cognitive health research, including limited representativeness (e.g., racial/ethnic, geographic) and accuracy of cognitive measurement tools. We provide study rationale and design, then describe baseline demographics, clinical, and neuropsychological characteristics stratified by vulnerability to cognitive decline. Initial results support the feasibility to detect mild cognitive impairment and describe at-risk cognitive health trajectories in an ecologically valid and demographically diverse aging population.
Non-Invasive Blood Glucose Monitoring with Armband-Embedded Antenna Sensor and RADWT Algorithm
Authors: S Sindhuja , E Kanniga
Published: March 2024

Researchers are continuing to align new technology and increased medical understanding to provide even more ways to help diabetics live healthier lives. Antenna sensors are also being developed for non-invasive glucose monitoring. Wearable technology in healthcare has several advantages, including convenience, lower healthcare costs, improved diagnosis, and improved patient outcomes. A wearable patch antenna can be a passive sensor to detect various body signals. Signal acquisition and linear regression modeling monitor fluctuating diabetes levels with an antenna sensor. The antenna's operating frequency is set to 4.1 GHz, which is in the industrial, scientific, and medical (ISM) frequency band. As a substrate material, rigid FR4 (r = 3.5, tan = 0.0027, and thickness of 0.1 mm) is used. The proposed antenna will improve return loss, VSWR, gain, and efficiency. In comparison to other existing wearable antennas, it has a lower return loss, VSWR, gain, and specific absorption rate (SAR). The achieved antenna return loss at 4.1 GHz is approximately 37 dB, the achieved directivity at 4.1 GHz is 2.1 dBi and the achieved gain is 1.8 dBi. The VSWR value obtained at 4.1 GHz is acceptable in terms of impedance matching. The proposed antenna design is designed and simulated using CST. The acquired signal from the thumb tip antenna was processed using the linear regression algorithm to calculate the blood glucose level. The experimental results indicate that, with regression modeling, the signal from the thumb tip antenna could be used to more reliably monitor blood glucose levels than existing invasive methods. The experimental results validated blood glucose levels taken from the thumb tip using an AccuChek glucometer.
Managerial identity work: A systematic literature review with a conceptual model
Authors: Westen Wiktoria A. , Graça Manuel A. da
Published: March 2024

The concept of managerial identity work (MIW) has been studied for two decades and is aptly recognized as a vital part of organizational life. Since MIW applies to each manager regardless of their seniority, it attracts researchers eager to apply theoretical frameworks to business scenarios collected from the whole managerial cohort. This systematic review contributes to the literature on MIW by accumulating and analyzing 55 empirical articles on the subject. Based on a synthesis approach, the findings point to eight first-order themes influencing MIW, namely, the identity of first-time managers, the identity of experienced managers, management development programmes, blurred identity, identity work as a medium, external perceptions of identity, creation of preferred identity, and the identity of minorities. These are later integrated into second-order themes such as knowledge, awareness, motive, and privilege, which allows for the creation of a conceptual model explaining the relation between the themes. Therefore, this study not only summarizes the existing research on MIW but also suggests to scholars and practitioners which factors impact managerial identity shaping; thus, what requires attention when seeking managerial identity development. The review includes a summary of the countries and industries in which MIW has been studied and lists the journals that published the reviewed articles. Additionally, it outlines avenues for future research, one of them in association with the 2030 Agenda for Sustainable Development of the United Nations.
JEL Codes: D21, D23, M53
Decompressive Craniectomy at the National Hospital of Niamey: Prospective Study of the Epidemioclinical Profil, Indications, Surgical Techniques, and Results in a Context of Limited Resources
Authors: Hamma Ousmane Issoufou , Kelani Aminath Bariath , Ango Souleymane Mahamadou , Hissene Tidjani Mahamat , Mobarak Salifou Mahamane , Tounga Yahouza Boka , Ibrahim Assoumane Issa , Dechambenoit Gilbert
Published: March 2024

Background: Decompressive craniectomy (DC) is a neurosurgical technique that is receiving renewed interest because of the resurgence of head injuries worldwide. Our aim was to analyze the quality of management and prognosis of patients who underwent this surgery in the context of limited resources.
Methods: This was a prospective, longitudinal, descriptive, and analytical study following STROBE, lasting 36 months (October 2020 to October 2023) at the National Hospital of Niamey in patients who had undergone DC. A p value ≤ 0.05 was considered to indicate statistical significance.
Results: During our study, we collected 74 cases of DC. The mean age was 32.04 years (10 to 75 years), and there was a male predominance (91.89%). DC was performed mainly following head trauma (95.95%; 71/74), the main cause of which was road traffic accidents (76%; 54/71). On admission, most patients presented with altered consciousness (95.95%) and pupillary abnormalities (62.16%). The average time to complete the brain scan was 31.28 hours, with parenchymal contusion being the most common lesion (90.54%). The majority of patients (94.59%) underwent decompressive hemicraniectomy. Postoperative complications occurred in 71.62% of all patients, 33.78% (25/74) of whom died. Among survivors, 55.10% had neurological sequelae at the last consultation (27/49). The main factors associated with the risk of death and morbidity were a Glasgow Coma Scale (GCS) ≤ 8, pupillary abnormality on admission, presence of signs of brain engagement, and a long admission delay.
Conclusions: Our study showed that the impact of limited resources on our care is low. However, it is crucial to develop judgment criteria that are adaptable to our realities.
Amiloride vs. furosemide for the treatment of edema in human nephrotic syndrome: a pilot study (AMILOR)
Authors: Schork Anja , Vogel Elisabeth , Bohnert Bernhard N. , Essigke Daniel , Wörn Matthias , Fischer Imma , Heyne Nils , Birkenfeld Andreas L. , Artunc Ferruh
Published: March 2024

In rodent models of nephrotic syndrome (NS), edema formation was prevented by blockade of the epithelial sodium channel ENaC with amiloride. The monocentric randomized controlled AMILOR study investigated the antiedematous effect of amiloride (starting dose 5 mg/d, max. 15 mg/d) in nephrotic patients in comparison to standard therapy with the loop diuretic furosemide (40 mg/d, max. 120 mg/d) over 16 days. Overhydration (OH) was measured by bioimpedance spectroscopy (Body Composition Monitor, Fresenius). Depending on the OH response, diuretic dose was adjusted on days 2, 5, 8 and 12, and if necessary, hydrochlorothiazide (HCT) was added from d8 (start 12.5 mg/d, max. 25 mg/d). The primary endpoint was the decrease in OH on d8. The study was terminated prematurely due to insufficient recruitment and a low statistical power due to a low actual effect size. Median baseline OH was + 26.4 (interquartile range 15.5–35.1) % extracellular water (ECW) in the amiloride arm and + 27.9 (24.1–29.4) % ECW in the furosemide arm and decreased by 1.95 (0.80–6.40) and 5.15 (0.90–8.30) % ECW after 8 days, respectively, and by 10.10 (1.30–14.40) and 7.40 (2.80–10.10) % ECW after 16 days, respectively. OH decrease on d8 and d16 was not significantly different between both arms. In conclusion, the AMILOR study is the first randomized controlled pilot study suggesting a similar antiedematous effect as furosemide. Thus, amiloride emerges as an alternative to the standard therapy with furosemide.
Radio «Kultura» Music Content
Authors: Medynska Olesia , Hnatyshyn Solomiia
Published: March 2024

Introduction. Radio “Kultura” is a producer of musical intentions, a translator of traditions and innovations in modern musical art. The musical content of the analyzed media is characterized by a multifaceted musical palette. Informing about musical events and processes, radio “Kultura” becomes a unique platform for the actualization of musical culture, public discussion of musical issues, formation of worldview orientations and musical requests of the audience.
Relevance and aim of the research. The relevance of scientific research is determined by the absence of research into the musical content of radio “Kultura” in the modern scientific discourse.
The aim of the articles is to analyze musical content radio “Kultura” in the focus of the problem-thematic paradigm and media consumption.
Methodology. While carrying out the research, general philosophical and general scientific (theoretical, empirical) methods were used, in particular, the method of terminological and conceptual analysis, analysis of scientific literature, synthesis, induction and deduction, generalization, monitoring, content analysis, online surveys, statistical analysis.
Results. It has been clarified definition the concept of “musical content”. The problem-thematic range of materials was analyzed. An online survey was conducted of reception the audience musical content of radio “Kultura”.
Conclusions. Having analyzed the music content of radio “Kultura”, we identified the main thematic groups: news of the musical life of Ukraine, the most important events in the field of world music, stories about outstanding musical figures, musical genres and styles, trends in the music industry at the local and global levels, cultural and musical events, innovations, etc. In the analyzed media, the problems of the functioning and transformation of folk music, the connection of the author/performer with other participants of the musical ecosystem, pricing in the industry, age and gender discrimination in show business, music piracy, etc. are actualized. The results of the survey state that the respondents choose radio “Kultura” consciously and rationally, taking into account the quality of the musical content, the reputation of the media, and thematic priorities. Musical content partially meets their informational expectations.
Journal of Ecological Engineering Design Takes Flight
Authors: Beutel Marc W. , McMillan Sara
Published: March 2024

Thank you to all who have made it possible for our dream of an ecological design-focused, open access, AEES-endorsed journal to take flight
Investigating the Genuineness of Suicide Notes in Social Media
Authors: Widiatmika Putu Wahyu , Pastika I Wayan , Satyawati Made Sri
Published: March 2024

This study aims to find linguistic evidence that is able to act as legal evidence in determining the genuineness of a suicide note. The data sources were written and digital suicide notes from Indonesia. The data were collected from social media through documentation. The data collected were graphology and lingual units that indicate the linguistic features of a genuine suicide note. The units were seen from their structure, meaning, and context to determine the motivation. The data were analyzed through referential identity, orthography identity, and distributional methods from descriptive-qualitative and descriptive-quantitative approaches based on linguistic theories. The theories applied were intertextuality, meaning, linguistic features of suicide notes, the context of the situation, and generative transformation. The findings show that written and digital suicide notes, as well as posts on the victimâ€™s social media, provide evidence that the note is genuine and written by the victim. The evidences are recursive graphology, interrelated propositions, and linguistic features of a genuine suicide note. The motivations for suicide are derived from the victimâ€™s self-blaming, his acknowledgment of his inability to help himself from financial and mental issues, and a constant feeling of being a disappointment to people who had supported him.
Grammatical Analysis of the Quality of Abdi Dalem's Written Language Variety of Ngayogyakarta Hadiningrat Palace, Indonesia
Authors: Yuliati Ria , Sajarwa Sajarwa , Winarti Daru
Published: March 2024

Abdi Dalem is the King's Assistant at the Ngayogyakarta Hadiningrat Palace, Indonesia, which has a special variety of written language. This research aims to formulate the variety of Abdi Dalem written language in the kedhaton (inner core) environment of Ngayogyakarta Hadiningrat Palace as well as grammatical analysis to improve the quality of the variety of written language. This research is descriptive qualitative research. The form of this research data is a variety of Abdi Dalem written language in the kedhaton (inner core) environment of the palace in the form of regulations, bulletins, official letters and Abdi Dalem training books. The data were collected by identifying the places and samples, reviewing related literature, reviewing various written languages, and doing an interview. Data analysis techniques are describing Abdi Dalem, linguistic analysis of Abdi Dalem's written language, and data interpretation. The results of the research show that the variety of Abdi Dalem's official written language consists of 1) the Bagongan variety of Javanese, 2) Indonesian. The grammatical inaccuracy of Abdi Dalem's variety of written language consists of 1) Bagongan lexicon inaccuracy, 2) New Javanese vocabulary inaccuracy, 3) inaccuracy in the use of the New Javanese Ngoko (N) affix, 4) spelling inaccuracy. With this grammatical analysis, it is hoped that it can improve the quality of Abdi Dalem Ngayogyakarta Hadiningrat Palace's variety of written language.
Pattern Recognition of EFL University Studentsâ€™ Online Behaviors through Data Science: Any Investment on English Language Components or Skills?
Authors: Arabshahi Maryam , Kafi Zeinab , Krummacker Dennis , Schotten Hans D.
Published: March 2024

Artificial intelligence (AI) has played a crucial role in many fields of study, and its merits and demerits have been investigated by related scholars. However, it seems a somewhat gray area when implementing AI in teaching and learning. This could be mainly because AI developers know little about learning varied sciences and they also lack pedagogical knowledge for implementing AI in teaching (Luckin & Cukurova, 2019). Therefore, the current research aimed at gathering data regarding the online behaviors of 21 Iranian EFL university students through installing an application on their mobile phones for a period of eight days. Afterwards, the collected data were analyzed through Data Science methods and varied patterns of behavior were recognized. The results exhibited that messaging and social media applications are two great parts of the studentsâ€™ life. Also, there existed some common patterns regarding the applications students owned and the amount of time they spent on them. As a small case in point, the results of the study cannot be generalized; however, the outcomes highlight the proof that in an EFL context, serious steps need to be adopted by course designers and stakeholders in order to cultivate a greater and purposeful use of online learning applications, websites etc. among EFL university students so as to enhance the teaching-learning process. This gains prominence because any AI-mediated learning approach is believed to enhance studentsâ€™ second/foreign language motivation as well as self-regulation in learning. AI is actually promising a revolution in the realm of language education.
Navigating Foreign Language Teaching Anxiety: Insights from Pre-Service Teachers during Teacher Professional Education Practicum
Authors: Sanjaya Masud Madhani , Nurkamto Joko , Sumardi Sumardi
Published: March 2024

This study focuses on the experiences of pre-service teachers that may trigger anxiety and delve into the potential benefits and effectiveness of FLTA in enhancing language acquisition and proficiency. By conducting in-depth studies and investigations on this topic, researchers look at the impact of FLTA. They can better understand how FLTA can optimize their problem-solving skills to facilitate language learning and provide valuable insight for language education, especially in EFL classrooms. This study used a narrative strategy to investigate the pre-service EFL teachers' experiences with teaching foreign language anxiety during their teaching practice while enrolled in the Teacher Profession Education Program. The subjects of this study were 3 English pre-service teachers who had completed teaching practice in junior and senior high schools during a professional teaching program in the city of Solo and its surroundings, Central Java, Indonesia. As a result of this study, several sources contributed to participants' experience of teaching foreign language anxiety, such as self-perception of language proficiency, leading inexperience, lack of student interest, fear of negative evaluation, and lack of time and class management. Participants in the teaching practicum also attempt to confront and overcome their worries; the strategies are personal coping strategies, professional coping strategies, social coping strategies, and institutional coping strategies. Although the participants experienced some anxiety while teaching practicum, they overcame it through various strategies. So, leading practicum activities from one meeting to the following allowed participants to develop their abilities and overcome their concerns about teaching in the EFL classroom.
Social integration of internally displaced persons in Ukraine: Problems and challenges for governing local communities
Authors: Roshchyk Iryna , Bilan Yuriy , Krol Vita , Mishchuk Halyna
Published: March 2024

This study aims to evaluate social integration and obstacles for internally displaced persons (IDPs) in local communities for further improvement of governing local communities regarding the integration of IDPs in new surroundings. The expert sample included 38 representatives of relevant authorities, scientists, NGOs, and volunteer organizations from 11 Ukrainian regions. The survey was conducted using the online questionnaire method via Google Forms. The results show the low participation of IDPs in most political and civil activities in new communities. The level of social integration according to these criteria is, respectively, 3.0 and 3.2 points out of 6 possible. At the same time, the level of economic integration (3.7 points) and integration into cultural and sports initiatives (3.6 points) are comparatively high, which are a feature illustrating the readiness to be involved in some kinds of activities in a new community. A significant result is also the fact that according to most signs of social integration, in the evaluations of experts, there are assessments of the activity of IDPs at a level that exceeds the activity of residents (6 points). Such results indicate the existence of a resource for developing communities due to the use of the potential of IDPs. This is especially characteristic of activities in counteraction to russian aggression, involvement in grant and project activities, search for opportunities for legal income, and support of social justice principles in labor relations.
AcknowledgmentThis study is funded by the National Research Foundation of Ukraine under project No.2021.01/0343 “Ensuring social protection of ATO/JFO participants and social integration of IDP under the condition of increasing threats to social security.”
DEĞİŞEN TOPLUMDA DÜNYA AİLELERİ: AİLE ÖRÜNTÜLERİ VE HASTALIKTA, SAĞLIKTA EVLİLİKLER
Authors: Varışlı Berfin , Kurdoğlu İris , Ergin Su
Published: March 2024

Günümüzde dünya genelindeki toplumsal ilişkilerin birbiriyle bağlantılı olacak şekilde yoğunlaşmasının bir ifadesi olan küreselleşme süreçleriyle birlikte yaşanan hızlı değişim, toplumsal yapıyı ve yaşamı belirleyen kurumların değişimine neden olmaktadır. Aile, bu değişimi, yapısı ve örüntüleriyle derinden hisseden kurumların başında gelmektedir. Sanayileşme, modernleşme, kentleşme ve toplumsal rollerde gerçekleşen dönüşümler geleneksel ailenin işlevlerinin giderek farklılaşan süreçlerle karşılaşmasına, bu süreçlerin zorunlu bir sonucu olarak çekirdek aile modelinin ortaya çıkmasına yol açmıştır. Çekirdek aile, mevcut kültürel değerlerin bir kısmını bünyesinde barındırsa da günümüz toplumlarının bireyselleşmiş yaşam deneyimlerinin bir sonucu ve geleneğin otoritesinde yaşanan değişime paralel olarak temelinde farklı ülkelerden ve kültürlerden gelen ya da farklı ülkelerde yaşayan bireyler arasında kurulan yeni aileler ortaya çıkmıştır. Bu yeni postmodern aileler, Ulrich Beck ve Elisabeth Beck-Gernsheim tarafından dünya aileleri olarak tanımlanmıştır. Dünya aileleri, günümüzde yapısal ve mekânsal sınırların belirsizleşmesi ile mümkün hale gelmiştir. Bununla birlikte günümüzde boşanma, küresel bir olguya dönüşmekte, yeniden evlenmelerse daha yaygın hale gelmektedir. Bu çalışmada dünya aileleri kavramından hareketle Türkiye’de ve dünyada ailenin değişen yapısı ve örüntüleri OECD ve TÜİK verilerinin desteğiyle incelenerek günümüz ailelerinin, dünya aileleri kavramı kapsamında değerlendirilebileceği sonucuna varılmıştır.
GELİŞİMSEL YETERSİZLİĞİ OLAN ÇOCUKLAR İÇİN TEHLİKE İÇEREN UNSURLARIN EBEVEYN BAĞLAMINDA İNCELENMESİ
Authors: Demirel Özlem , Yildirim Bedia
Published: March 2024

Tehlike durumları, bireylerin hayati fonksiyonlarının azalmasına hatta kaybolmasına neden olabilecek durumlardır. Her yaş grubu için büyük risk oluşturan bu durumlar, özellikle gelişimsel yetersizliği olan çocuklar açısından riskin artmasına neden olabilmektedir. Gelişimsel yetersizliği bulunan çocuklar, özellikleri gereği tehlike içeren ve içermeyen unsurları birbirinden ayırt etmekte zorlanabilmektedirler. Bu durum çocukların, tehlikelere daha fazla maruz kalmalarına sebep olabilir, bulundukları mekânlarda tehlikelere karşı ek önlemlerin alınmasını gerekli kılabilir. Bu çalışma, gelişimsel yetersizliği bulunan çocuklara sahip ebeveynlerin, ev, okul ve dış ortamlarda çocukları için tehlikeli olarak tanımladıkları unsurların neler olduğunu, belirttikleri unsurlara yönelik almış oldukları tedbirleri ve olası risklerin kendilerinde oluşturdukları ruhsal durumu belirlemek amacıyla yapılmıştır. Araştırma, belirlenen amaç doğrultusunda nitel araştırma yöntemlerinden durum çalışması olarak desenlenmiş ve araştırmada görüşme tekniği kullanılmıştır. Araştırmanın çalışma grubu oluşturulurken amaçlı örnekleme yöntemi kullanılmıştır ve özel gereksinimli çocuğa sahip 20 ebeveyn çalışma grubuna dahil edilmiştir. Verilerin toplanması amacıyla yarı yapılandırılmış görüşme yöntemi tercih edilmiş, görüşme sonrasında ebeveynlerden gelen cevaplar kategorize edilerek tablolaştırılmıştır. Elde edilen bulgulara göre; ebeveynlerin ev içerisinde yanıcı kesici ve delici aletler, merdivenler, elektronik aletler ve ıslak zeminleri, okul içerisinde merdiven, oyun alanları, kapı ve pencereler ile tuvaletleri, ev ve okul dışı ortamlarda yabancı insanları, trafik ve oyun/park alanlarını tehlikeli olarak gördükleri, ebeveynlerin çocuklarına dair en büyük kaygılarının ise gelecek kaygısı olduğu sonucuna ulaşılmıştır.
Investigation of innovative designs of high-velocity channels for damping kinetic energy of flows
Authors: Rustem Ergali , Yestaev Kuat , Akhmetov Ergali , Abduvalova Ainur , Orynbassar Temirlan
Published: March 2024

In our contemporary world, demanding sustainable resource management, the study focuses on innovative fast flow channel designs. It investigates their efficacy in reducing flow kinetic energy, aiming to optimize water and energy management and diminish flood risks. Employing diverse methodologies, it analyzes and develops these designs, proving their substantial impact on stream energy management. These innovations not only enhance energy efficiency but also mitigate risks associated with excess kinetic energy, promoting safer stream management. This research significantly contributes to fluid dynamics and engineering, deepening the understanding of kinetic energy control in flows and offering potential solutions for water supply, environmental sustainability, and infrastructure safety challenges.
A Systematic Review of the Novel Targeted Immunobiological Medications in
Rheumatoid Arthritis: Efficacy, Safety, and Innovation
Authors: Parchami Ghazaee Sepideh , Marchenko-Tolsta Kateryna , Sereda Petro , Hameed Murtaza , Lane Sandra
Published: March 2024

Introduction:

Over the last half-century, the treatment and management of autoimmune rheumatic diseases have progressively improved, particularly with the
contribution of immunobiological or biological therapies known as disease-modifying antirheumatic drugs. Although these agents have been
generally efficient in the management of rheumatoid arthritis (RA), some patients experience limited efficacy and non-responsiveness to treatment.
In addition, they may cause adverse clinical effects, further aggravating the disease.

Objectives:

Despite advancements in biological therapies, significant clinical needs persist. This review aims to discuss novel treatments, guiding future
guidelines and drug discoveries for rheumatoid arthritis.

Methods:

This review follows the 2020 PRISMA statement, utilising PubMed and Google Scholar for literature search and emphasizing recent meta-analyses
on the safety and efficacy of targeted immunobiological medications.

Results:

Small molecule inhibitors, whether utilised independently or in conjunction with Methotrexate, have been shown to contribute to effective disease
management and have the potential for better adherence to the American College of Rheumatology criteria. Tocilizumab therapy demonstrates a
significant reduction in disease activity and improves rates of disease remission when combined with Methotrexate. Investigations of mesenchymal
stromal cell therapies have had promising outcomes, improving both cartilage quality (as evaluated by Macroscopic Cartilage Repair Assessment)
and joint tenderness and swelling in clinical joint counts. Intra-articular administration of tolerogenic dendritic cells has displayed a capacity to
alleviate pain, as measured by Visual Analog Scale scores, and enhance the Disease Activity Score across 28 joints. Resveratrol capsules
supplemented with allopathic therapy show potential in reducing TNF-α and interleukin-6 serum levels.

Conclusion:

More investigations and their analysis will improve patient outcomes and reduce adverse effects and the costs involved in developing and obtaining
immunobiological drugs. Moreover, assessing the safety and efficacy of anti-RA properties of the bioactive compounds could offer less toxic and
more cost-effective natural treatment options.