bluuebunny/crossref_metadata_2025 huggingface dataset:
Parkes: Thirty Years of Radio Astronomy
Authors: Milne DK
Published: February 2019

The opening of the Parkes radio telescope in October 1961 placed Australia at the forefront of international research in radio astronomy and ushered in an era of rapid developments in our understanding of the origin and nature of the Universe and our place within it. Thirty years later, the scientists, engineers and technical staff involved in the establishment, operation and subsequent development of this most successful of Australian research instruments gathered to review and reflect on their achievements, and to recount many of the human stories that were so intimately bound up with this extraordinarily productive period in Australia's scientific history.
This book presents their accounts of the work and life at Parkes, and provides a fresh perspective on the growth of Australian science over the past three decades.
Tettigoniidae of Australia Volume 3
Authors: Rentz David
Published: February 2019

This third volume in the series will assist with identification and study of this important genus. Specialised collecting techniques, and the rearing of immature specimens, have yielded many more species than would otherwise have been recorded using only normal collecting techniques.
The work accounts for four subfamilies, two of which, the Tympanophorinae and Microtettigoniinae, are endemic to Australia. Each of these endemic subfamilies is represented by a single genus containing several species.
Tettigonidae of Australia Volume 3 will be a valuable resource for orthoptera researchers and academics, general entomologists, as well as those with an interest in the ecology and conservation issues related to grasshoppers.
Catchment Scale Recharge Modelling - Part 4
Authors: Hatton TJ
Published: February 2019

This paper addresses the need to model recharge to groundwater systems at the scale of whole catchments. It looks at developing the right conceptual model of how water moves through a given landscape for both homogeneous and heterogeneous catchments. One-dimensional recharge models and three-dimensional recharge models are considered. Discussion of which recharge modelling approach to use take in consideration of the availability of data, the nature of the questions being asked, and the expertise of the investigators.
Using Groundwater Responses to Infer Recharge - Part 5
Authors: Armstrong D , Narayan K
Published: February 2019

Analytical methods of assessing the response of groundwater levels to a range of factors, including elastic (barometric and tidal) influences in confined aquifers and recharge to unconfined aquifers due to infiltration of rain and other surface water, are presented. Responses in a confined aquifer to distant recharge events and the associated time lag is discussed. Also covered are responses to changes in storage volume resulting from direct recharge at the outcrop of an unconfined aquifer system both seasonally and on a single recharge event basis. Worked examples and case histories are used to illustrate methods of estimating the amount of recharge at different sites within a catchment. The application of vertical cross-sectional flow nets to the estimation of recharge is presented in the context of recharge/discharge profiles.
Plot Scale Models and Their Application to Recharge Studies - Part 10
Authors: Walker GR , Zhang L
Published: February 2019

Each booklet in The Basics of Recharge and Discharge series covers a specific technique for detecting, measuring or modelling groundwater recharge and discharge. Part 10 provides an overview of the use of plot scale models in estimating deep drainage.
This booklet explains how such models can add understanding to deep drainage studies. It describes the different broad types of plot-scale models that are available and how they can be most appropriately used.
Throughout the booklet, clear examples demonstrate the potential applications for a range of simulation models. They contrast the features and capabilities of the models and illustrate what can be achieved through modelling. The chapter finishes by describing how to test models and where to find more information on the models most commonly used in Australia.
Australian Barleys
Authors: Fitzsimmons RW , Wrigley CW
Published: February 2019

This handbook provides a basis for checking the range of quality factors that can be judged by on-the-spot examination. When barley is being received at the silo or the malt-house, it is impractical and unnecessary to use the range of precise laboratory methods devised for quality testing, although these can be used to decide about border-line samples or to resolve disputes.
Instead, an approximate indication of many quality factors can be obtained by visual examination to determine:
(a) the variety, to make sure that the load is binned with other barley of a compatible quality type;
(b) the extent of damage to grains, as an indication of how satisfactory the grain will be for the particular use for which it is offered;
(c) the degree of contamination with foreign seeds, to determine the purity of the barley, the expense involved in cleaning it and its suitability for use as human or animal food depending on the toxicity of the contaminants.
In addition to these three aspects of quality, there are other factors such as test weight and protein content that can be measured on receival of grain, but they are beyond the scope of this book.
Origins of CSIRO
Authors: Currie George , Graham John
Published: February 2019

March 16th, 1966, marked the jubilee of Commonwealth sponsored scientific research in Australia. In 1916 the Commonwealth Government set up an Advisory Council of Science and Industry. This was the culmination of an interest in scientific research which went back to the very beginning of federation and had been expressed by active attempts to bring science to the aid of agriculture.
This book is an account of the developments which led up to the formation of the Advisory Council by the Hughes Government in 1916. It carries the story on to 1926, when a later Prime Minister, Mr S. M. Bruce, introduced the Bill to found the Council for Scientific and Industrial Research. In those days there were vivid contrasts in the views of scientists, politicians and men of affairs as to how science could most effectively influence the nation's future.
Vanished and Vanishing Parrots
Authors: Forshaw Joseph , Knight Frank
Published: February 2019

Joseph M. Forshaw, one of the world’s leading authorities on parrots, calls attention to the threats they face: they are one of the most endangered groups of birds, with a growing number of species nearing extinction. The main threats arise from habitat loss through deforestation and agricultural development and from the taking of birds for the international live-bird trade.
Vanished and Vanishing Parrots brings together information on species that have become extinct in historical times with information on species that are in danger of becoming extinct to increase public awareness of the plight of these magnificent birds. Vivid colour plates by the wildlife artist Frank Knight draw attention to the spectacular species that we have lost or that could be lost. Forshaw’s work gives us fascinating insight into these endangered and extinct parrots.
Vanished and Vanishing Parrots will be a valuable reference for scientific, ornithological and avicultural organisations, as well as individual lovers of birds and of illustrated natural history books.
Announced Highly Commended at the 2018 Whitley Awards
Future Park
Authors: Wright Amalie
Published: February 2019

The first public parks were created on urban 'greenfields'. Once these designated sites had been used, cities looked towards post-industrial sites, and built parks in places that had suffered from environmental degradation, neglect, abandonment and conflict. With finite stocks of urban post-industrial land now also approaching exhaustion, more ways of making parks are required to create inclusive, accessible and resilient urban places.
Future Park invites Australian built environment professionals and policymakers to consider the future of parks in our cities. Including spectacular images of public spaces throughout the world, the book describes the economic, social and environmental benefits of urban parks, and then outlines the threats and challenges facing cities and communities in an age when more than half the world's population are urban dwellers. Future Park introduces the need to embrace new public park thinking to ensure that benefits continue to be realised.
Future Park illustrates imaginative and resourceful responses to real challenges by highlighting recent proposals and projects. These projects coalesce around four broad themes – linkages, obsolescences, co-locations and installations – responding to contemporary urban paradoxes, and ensuring parks continue to play a vital role in the lives of our cities.
Gardens for All Seasons
Authors: Horsfall Mary
Published: February 2019

Gardens for All Seasons is a gardening lifestyle book by bestselling author Mary Horsfall, celebrating the role of gardens in our lives and advising on the timing of jobs in the gardening year throughout Australia.
Monthly chapters include topics such as planning, bushfire preparation, watering, pot plant care, mulching, weeding, fertilising, pruning, propagating, pest control, what to plant for different climate zones and what garden venues and events to visit.
Mary details her own gardening year, including jobs done, fruits and vegetables harvested, food cooked based on the harvest, what was in flower and wildlife observations – all on a month by month basis. Each chapter includes a special topic of the month, such as fun for kids in the garden, biodiversity, manipulating microclimate, and fragrance and first aid.
Covering both edible and decorative gardens, and including colour photographs as well as some of Mary’s own recipes, Gardens for All Seasons is sure to please all types of gardeners.
Clean Energy, Climate and Carbon
Authors: Cook Peter J
Published: February 2019

With the general reader in mind, Clean Energy, Climate and Carbon outlines the global challenge of decreasing greenhouse gas emissions. It covers the changing concentration of atmospheric carbon dioxide through time and its causes, before considering the promise and the limitations of a wide range of energy technologies for decreasing carbon dioxide emissions.
Despite the need to decrease carbon dioxide, the fact is that the global use of fossil fuels is increasing and is likely to continue to do so for some decades to come. With this in mind, the book considers in detail, what for many people is the unfamiliar clean energy technology of carbon capture and storage (CCS). How can we capture carbon dioxide from flue gases? How do we transport it? How do we store it in suitable rocks? What are suitable rocks and where do we find them? How do we know the carbon dioxide will remain trapped once it is injected underground? What does CCS cost and how do those costs compare with other technology options?
The book also explores the political environment in which the discussion on clean energy technology options is occurring. What will a price on carbon do for technology uptake and what are the prospects of cutting our emissions by 2020 and of making even deeper cuts by 2050? What will the technology mix look like by that time?
For people who are concerned about climate change, or who want to learn more about clean energy technologies, including CCS, this is the definitive view of the opportunities and the challenges we face in decreasing emissions despite a seemingly inexorable global increase in energy demand.
Owner Builder
Authors: Sipek Leeza , Sipek Matthew , Foote Hazel
Published: February 2019

Building your own home could save you thousands of dollars. The Owner Builder is an easy-to-understand, step-by-step guide for people who want to build their dream home in a financially responsible manner. From choosing a block of land to decorating the inside of the house, this book guides the reader through the entire building process.
The authors share their personal experiences with photos of the building process in 68 steps. They include tips and hints on the approval process, construction ideas and how to avoid mistakes. They also uncover potential hidden costs, and offer other ways to save money if you don't have time to manage the construction yourself – such as hire a project manager, which is cheaper than a contract builder.
Renovators, DIY enthusiasts and anyone considering building a home will find a wealth of practical information in this book. Even if you are hiring a builder, this book can help you understand what is involved in building a home and what to expect at each stage of the project.
Mathematical Morphology
Authors: Talbot Hugues , Beare Richard
Published: February 2019

Mathematical morphology is a powerful methodology for processing and analysing the shape and form of objects in images. The advances in this area of science allow for application in the digital recognition and modeling of faces and other objects by computers.
Mathematical Morphology is comprehensive work that provides a broad sampling of the most recent theoretical and practical developments in applications to image processing and analysis. Subject areas covered include: binary morphology, regularised region growing, morphological scale-space techniques, levelings, reconstruction, modeling and simulation, and applications as diverse as medicine, forestry and geology.
This fascinating research will be of great interest to engineers, computer scientists, mathematicians and statisticians whose research work is focussed on the theoretical and practical aspects of non-linear image processing and analysis. The content stems from the proceedings of the VIth International Symposium on Mathematical Morphology, held April 3–5, 2002 in Sydney, Australia.
Living Waters
Authors: Romanowski Nick
Published: February 2019

Wetlands are often seen as the ultimate symbol of beauty and tranquillity, their clear waters sheltering mysterious animals in a world where change is gentle and slow, from dragonflies skimming above their own reflections to the fishes glimpsed briefly below. Yet Australian wetlands are among the most varied and changeable habitats found anywhere, and the many creatures that live out their lives in and around water are superbly adapted to some of the most unpredictable ecosystems in the world.

This book follows the diverse common themes and patterns that link inland waters from Tasmania to the tropics. It shows how cycles of change, the ways that different wetland animals travel through and between wetlands, and the interactions of the animals themselves create an ever-changing ecological kaleidoscope. Drawing on what is known of the biology, ecology and even the genetics of many of the most abundant, widespread and successful groups of animals, the author shows similarities to wetlands in other parts of the world, as well as some of the more extreme environments and specialised animals that are unique to this continent.

Far more than a natural history, Living Waters explains the underlying forces that drive ecological change and movement in Australian wetlands, from the particular needs and habits of some specialised waterbirds to swarms of dragonflies and damselflies that may flourish for a few months before disappearing for years, and fishes found gasping in drying pools far from the nearest permanent water just hours after a desert deluge.
2014 Whitley Award Commendation for Aquatic Biology.
The Hawkesbury River
Authors: Boon Paul
Published: February 2019

The Hawkesbury River is the longest coastal river in New South Wales. A vital source of water and food, it has a long Aboriginal history and was critical for the survival of the early British colony at Sydney. The Hawkesbury’s weathered shores, cliffs and fertile plains have inspired generations of artists. It is surrounded by an unparalleled mosaic of national parks, including the second-oldest national park in Australia, Ku-ring-gai National Park. Although it lies only 35 km north of Sydney, to many today the Hawkesbury is a ‘hidden river’ – its historical and natural significance not understood or appreciated.
Until now, the Hawkesbury has lacked an up-to-date and comprehensive book describing how and when the river formed, how it functions ecologically, how it has influenced humans and their patterns of settlement and, in turn, how it has been affected by those settlements and their people. The Hawkesbury River: A Social and Natural History fills this gap. With chapters on the geography, geology, hydrology and ecology of the river through to discussion of its use by Aboriginal and European people and its role in transport, defence and culture, this highly readable and richly illustrated book paints a picture of a landscape worthy of protection and conservation. It will be of value to those who live, visit or work in the region, those interested in Australian environmental history, and professionals in biology, natural resource management and education.
Australian Rainforest Fruits
Authors: Cooper Wendy , Cooper William
Published: February 2019

This beautifully illustrated field guide covers 504 of the most common fruiting plants found in Australia's eastern rainforests, as well as a few species that are rare in the wild but generally well-known. These spectacular plants can be seen from Cape York to Victoria, with some species also found in the Northern Territory, Western Australia and overseas.
Rainforest fruits are often beautifully coloured, and in this guide the species are arranged by colour of ripe fruit, then by size and form. Five broad categories – pink to purple, blue to black, yellow and orange to red, green to brown, and white – allow people with even limited botanical knowledge to identify rainforest fruits.
Each species description is accompanied by a leaf drawing, a distribution map, and diagnostic characters to help the reader distinguish similar species.
Australian Rainforest Fruits includes stunning artwork by Australia’s leading natural history artist, William T Cooper. It will be sought not just by bushwalkers and natural history enthusiasts, but also by those who admire botanical art at its best.
Fur Seals and Sea Lions
Authors: Kirkwood Roger , Goldsworthy Simon
Published: February 2019

Fur seals and sea lions are charismatic, large carnivores that engage us with both their skill and playful antics. Although all species in Australian waters were harvested to near extinction 200 years ago, fur seals are recovering and are now common in near-shore waters across southern Australia. Sea lions, however, are endangered. Their populations appear not to have recovered like fur seals and are declining at some locations. Fur seals and sea lions are important top level predators and play an important role in Australia’s temperate marine ecosystems. Key threats they currently face relate to human activities, particularly interactions with fisheries.
This book outlines the comparative evolutionary ecology, biology, life-history, behaviour, conservation status, threats, history of human interactions and latest research on the three species of otariids that live in the waters of southern Australia: the Australian fur seal, New Zealand fur seal and Australian sea lion. It also includes brief descriptions of Antarctic and Subantarctic seals that occupy the Antarctic pack-ice and remote Australian territories of Macquarie Island and Heard Island.
Plastic Banknote
Authors: Solomon David , Spurling Tom
Published: February 2019

'Have you got any ideas on how to make a better banknote?'
In the late 1960s, the detection of counterfeit banknotes and the rise of new photographic and copying technologies prompted the Reserve Bank of Australia to explore options for increasing the security of currency. A top-secret research project, undertaken by CSIRO and the Bank, resulted in the development of the world’s first successful polymer banknotes. This technology is now used in over 30 countries.
This book describes the story of the Currency Notes Research and Development project from its inception in 1968 through to the release of the $10 Australian bicentennial plastic banknote in 1988. It exemplifies a market-driven project which resulted in advances in science, technology and approaches to commercialisation, and a fundamental change in banknote security.
Guide to the Cockroaches of Australia
Authors: Rentz David
Published: February 2019

Cockroaches! Even a mere mention of the word causes many people to recoil in horror. However, of the hundreds of species of cockroaches (or blattodeans as they are known) found in Australia, only a small number of them give the group a bad name. Just a few species that are commonly found in homes, restaurants and hospitals are responsible for thousands of dollars in expenditure to comply with health standards.
A Guide to the Cockroaches of Australia is a comprehensive account of most of the 550 described species found in Australia. The book reveals their diversity and beauty, it looks in detail at their morphology, habitats and ecology, and explains how to collect and preserve them. Importantly, it will allow pest controllers, students and researchers to reliably identify most of the common pest species as well as the non-pest cockroaches. It will also, perhaps, go some way towards elevating the reputation of these much-maligned insects, and promote further study of them.
2014 Whitley Award Commendation for Field Guide.
Australasian Nature Photography 10
Authors:   South Australian Museum
Published: February 2019

The bioregion of Australia, New Zealand, Antarctica and New Guinea possesses a unique natural heritage stretching back over 80 million years since the break-up of the great southern continent of Gondwana. The South Australian Museum and Australian Geographic focus on enhancing a general knowledge of this extraordinary legacy by encouraging photography of the region’s nature and wilderness, and promoting an annual competition to find the Australian Geographic ANZANG Nature Photographer of the Year.
Australasian Nature Photography: ANZANG Tenth Collection presents the finest photographs submitted to the 2013 Australian Geographic ANZANG Nature Photographer of the Year competition. Each photograph is accompanied by technical information as well as anecdotes about how the picture was taken, which will stimulate yet further interest in the flora and fauna and their conservation in the region.
Mt Stromlo Observatory
Authors: Bhathal Ragbir , Sutherland Ralph , Butcher Harvey
Published: February 2019

This book tells the story of the Mt Stromlo Observatory in Canberra which began with W.G. Duffield's idealism and vision in 1905. The Observatory began life as a government department, later becoming an optical munitions factory producing gun sights and telescopes during the Second World War, before changing its focus to astrophysics – the new astronomy.

In the ensuing years programs were introduced to push the Observatory in new directions at the international frontiers of astronomy. The astronomers built new, better and larger telescopes to unravel the secrets of the universe. There were controversies, exciting new discoveries and new explanations of phenomena that had been discovered. The Observatory and its researchers have contributed to determining how old the universe is, participated in the largest survey of galaxies in the universe, and helped to show us that the universal expansion is accelerating – research that led to Brian Schmidt and his international team being awarded the 2011 Nobel Prize in Physics.

These and other major discoveries are detailed in this fascinating book about one of the great observatories in the world.
Finding Australian Birds
Authors: Dolby Tim , Clarke Rohan
Published: February 2019

Finding Australian Birds is a guide to the special birds found across Australia's vastly varied landscapes. From the eastern rainforests to central deserts, Australia is home to some 900 species of birds. This book covers over 400 Australian bird watching sites conveniently grouped into the best birding areas, from one end of the country to the other. This includes areas such as Kakadu in the Top End and rocky gorges in the central deserts of the Northern Territory, the Great Barrier Reef in Queensland, rainforests distributed along the eastern Australian seaboard, some of the world's tallest forests in Tasmania, the Flinders Ranges and deserts along the iconic Strzelecki and Birdsville Tracks in South Australia, and the mallee temperate woodlands and spectacular coastlines in both Victoria and south west Western Australia.
Each chapter begins with a brief description of the location, followed by a section on where to find the birds, which describes specific birdwatching sites within the location's boundaries, and information on accommodation and facilities. The book also provides a comprehensive 'Bird Finding Guide', listing all of Australia's birds with details on their abundance and where exactly to see them.
Of value to both Australian birdwatchers and international visitors, this book will assist novices, birders of intermediate skill and keen 'twitchers' to find any Australian species.
Complete Field Guide to Butterflies of Australia
Authors: Braby Michael
Published: February 2019

As fascinating as they are beautiful, butterflies are a pleasure to watch and an important group of invertebrates to study. This second edition of the award-winning book The Complete Field Guide to Butterflies of Australia is a fully updated guide to all butterfly species on Australia's mainland and remote islands.

Written by one of Australia's leading lepidopterists, the book is stunningly illustrated with colour photographs, many of which are new, of each of the 435 currently recognised species. There is also a distribution map and flight chart for each species on the Australian mainland, together with information on similar species, variation, behaviour, habitat, status and larval food plants.
The introduction to the book covers adult structure, higher classification, distribution and habitats, as well as life cycle and behaviour. A new chapter on collecting and preserving butterflies is included. There is also an updated checklist of all species, a glossary, a bibliography and indexes of common and scientific names.
Positive Energy Homes
Authors: Brimblecombe Robin , Rosemeier Kara
Published: February 2019

Positive energy homes enable people to live healthy and comfortable lives with energy left over to share. Creating a house you love that produces surplus energy is surprisingly easy with a thorough understanding of how buildings work and careful attention to detail in construction.
The Passive House standard, with its well-proven track record, forms the basis for creating positive energy homes. This book explores the Passive House ‘fabric first’ approach, as well as the science and practicalities of effective ventilation strategies, smart options for heating and cooling, daylight harvesting, and efficient lighting and appliances.
Positive Energy Homes provides home owners world-wide, architects and builders with an understanding of the principles and technical details of building these houses.
Mountain Ash
Authors: Lindenmayer David , Blair David , McBurney Lachlan , Banks Sam
Published: February 2019

Mountain Ash draws together exciting new findings on the effects of fire and on post-fire ecological dynamics following the 2009 wildfires in the Mountain Ash forests of the Central Highlands of Victoria. The book integrates data on forests, carbon, fire dynamics and other factors, building on 6 years of high-quality, multi-faceted research coupled with 25 years of pre-fire insights.

Topics include: the unexpected effects of fires of varying severity on populations of large old trees and their implications for the dynamics of forest ecosystems; relationships between forest structure, condition and age and their impacts on fire severity; relationships between logging and fire severity; the unexpectedly low level of carbon stock losses from burned forests, including those burned at very high severity; impacts of fire at the site and landscape levels on arboreal marsupials; persistence of small mammals and birds on burned sites, including areas subject to high-severity fire, and its implications for understanding how species in this group exhibit post-fire recovery patterns.

With spectacular images of the post-fire environment, Mountain Ash will be an important reference for scientists and students with interests in biodiversity, forests and fire.
Exploring Soils
Authors: Grover Samantha , Heisler Camille
Published: February 2019

Have you ever wondered what happens in the earth underneath us? James has, and he wants to learn more about soil. In Exploring Soils: A Hidden World Underground, James discovers that soil is not just dirt for digging in. He explores how plants and animals live in soil, how soils are formed, how they differ, and the ways that soil is essential in our lives.
Written by Samantha Grover, a soil scientist and parent, and with engaging illustrations by artist Camille Heisler, Exploring Soils will take you to an underground world filled with activity and discoveries.
Exploring Soils is perfect for primary aged readers.
Notable Book, The CBCA Eve Pownall Award for Information Books 2018
Shortlisted for The Wilderness Society's Annual Environment Award for Children's Literature 2018
Animal Eco-Warriors
Authors: Gill Nic
Published: February 2019

Come on an action-packed adventure with an amazing mob of animal eco-warriors as they use their special talents to help solve our planet’s environmental problems!
From the nosy noses of biosecurity beagles at airports to rats learning to sniff out landmines in war-torn landscapes, animals are using their unique abilities to help make the world a better and safer place. With fantastic colour photos of animal eco-warriors at work, this book is full of fun facts on how animals are helping humanity work towards a more sustainable future. There are also plenty of tips on how you can make a difference to the planet. Join the animal eco-warrior team today!
This book is ideal for teachers and librarians looking for locally relevant, teachable materials addressing environment and sustainability issues, as well as for children and their families with an interest in animals and science.
Perfect for readers aged 9-12.
Notable Book, The CBCA Eve Pownall Award for Information Books 2018
Recipient of a 2017 Froggatt Award for Communication
Securing Australia's Future
Authors: Torok Simon , Holper Paul
Published: February 2019

The future will bring change for Australia. But whether that change is for the better or worse largely depends on the decisions we make today as individuals and as a nation. Recognising rapid changes in the global economy, environment and policy, the Australian Government engaged the Australian Council of Learned Academies (ACOLA) to undertake detailed interdisciplinary research to help guide Australian thinking and policy decisions.
Dozens of Australia’s finest minds assessed the opportunities available to the nation globally and domestically, charting a course for the future. The resulting findings can prepare Australia to address the challenges ahead and make the most of the opportunities. Securing Australia’s Future synthesises the major themes that emerge from ACOLA’s reports. Each chapter includes key findings designed to optimise Australia’s prosperity and place in the region.
The future is a long game but its base must be built now. This book provides a vision for the nation, for its politicians, public servants and industry leaders – a sound footing for securing Australia’s future. It is a vital resource for Members of Federal and State parliaments, senior public servants, industry leaders, universities and the interested public.
Australasian Eagles and Eagle-like Birds
Authors: Debus Stephen
Published: February 2019

Eagles are awe-inspiring birds that have influenced much human endeavour. Australia is home to three eagle species, and in Melanesia there are four additional endemic species. A further three large Australian hawks are eagle-like. Eagles, being at the top of the food chain, are sensitive ecological barometers of human impact on the Earth’s ecosystem services, and all of the six Australian species covered in this book are threatened in at least some states (one also nationally). Three of the four Melanesian tropical forest endemics are threatened or near-threatened.
In Australasian Eagles and Eagle-like Birds, Dr Stephen Debus provides a 25-year update of knowledge on these 10 species as a supplement to the Handbook of Australian, New Zealand and Antarctic Birds (HANZAB) and recent global treatises, based partly on his own field studies. Included are the first nest or prey records for some Melanesian species. This book places the Australasian species in their regional and global context, reviews their population status and threats, provides new information on their ecology, and suggests what needs to be done in order to ensure the future of these magnificent birds.
Australasian Eagles and Eagle-like Birds is an invaluable resource for raptor biologists, birdwatchers, wildlife rescuers and carers, raptor rehabilitators and zookeepers.
Kosciuszko Alpine Flora: Field Edition
Authors: Totterdell CJ , Costin AB , Wimbush DJ , Gray M
Published: February 2019

Around Australia’s highest mountain lies a rare ecosystem, an alpine area of outstanding beauty and diversity, strikingly different from other alpine ecosystems of the world but with common features.

Kosciuszko Alpine Flora describes and illustrates the area’s 212 flowering plants and ferns, of which 21 are endemic. It discusses the geological and human history of the area, the life-forms and habitats of the plants, and explores the various plant communities and their environmental relationships.

Ideal for the tourist or general interest reader, this field edition excludes the detailed taxonomic section.
Extracellular vesicles derived from cancer‐associated fibroblasts induce the migration and invasion of oral squamous cell carcinoma
Authors: Dourado Mauricio Rocha , Korvala Johanna , Åström Pirjo , De Oliveira Carine Ervolino , Cervigne Nilva K. , Mofatto Luciana Souto , Bastos Debora Campanella , Messetti Ana Camila Pereira , Graner Edgard , Leme Adriana Franco Paes , Coletta Ricardo D. , Salo Tuula
Published: February 2019

As one of the most abundant constituents of the tumour microenvironment (TME), cancer‐associated fibroblasts (CAF) display critical roles during tumour progression and metastasis. Multiple classes of molecules including growth factors, cytokines, proteases and extracellular matrix proteins, are produced by CAF to act as mediators of the stroma‐tumour interactions. One of the main channels for this communication is associated with extracellular vesicles (EV), which are secreted particles loaded with protein and genetic information. In this study, we evaluated the effects of EV derived from CAF primary human cell lines (n = 5) on proliferation, survival, migration, and invasion of oral squamous cell carcinoma (OSCC) cells. As controls, EV from human primary‐established normal oral fibroblasts (NOF, n = 5) were used. Our in vitro assays showed that CAF‐EV significantly induces migration and invasion of OSCC cells and promote a disseminated pattern of HSC‐3 cell invasion in the 3D organotypic assay. Furthermore, gene expression analysis of EV‐treated cancer cells revealed changes in the pathways associated with tumour metabolism and up‐regulation of tumour invasion genes. Our findings suggest a significant role of CAF‐EV in promoting the migration and invasion of OSCC cells, which are related to the activation of cancer‐related pathways.
Comparison of six breast cancer classifiers using qPCR
Authors: Berchtold Evi , Vetter Martina , Gündert Melanie , Csaba Gergely , Fathke Christine , Ulbrich Susanne E , Thomssen Christoph , Zimmer Ralf , Kantelhardt Eva J
Published: February 2019

Motivation

Several gene expression-based risk scores and subtype classifiers for breast cancer were developed to distinguish high- and low-risk patients. Evaluating the performance of these classifiers helps to decide which classifiers should be used in clinical practice for personal therapeutic recommendations. So far, studies that compared multiple classifiers in large independent patient cohorts mostly used microarray measurements. qPCR-based classifiers were not included in the comparison or had to be adapted to the different experimental platforms.

Results

We used a prospective study of 726 early breast cancer patients from seven certified German breast cancer centers. Patients were treated according to national guidelines and the expressions of 94 selected genes were measured by the mid-throughput qPCR platform Fluidigm. Clinical and pathological data including outcome over five years is available. Using these data, we could compare the performance of six classifiers (scmgene and research versions of PAM50, ROR-S, recurrence score, EndoPredict and GGI). Similar to other studies, we found a similar or even higher concordance between most of the classifiers and most were also able to differentiate high- and low-risk patients. The classifiers that were originally developed for microarray data still performed similarly using the Fluidigm data. Therefore, Fluidigm can be used to measure the gene expressions needed by several classifiers for a large cohort with little effort. In addition, we provide an interactive report of the results, which enables a transparent, in-depth comparison of classifiers and their prediction of individual patients.

Availability and implementation

https://services.bio.ifi.lmu.de/pia/.

Supplementary information

Supplementary data are available at Bioinformatics online.
rMETL: sensitive mobile element insertion detection with long read realignment
Authors: Jiang Tao , Liu Bo , Li Junyi , Wang Yadong
Published: February 2019

Mobile element insertion (MEI) is a major category of structure variations (SVs). The rapid development of long read sequencing technologies provides the opportunity to detect MEIs sensitively. However, the signals of MEI implied by noisy long reads are highly complex due to the repetitiveness of mobile elements as well as the high sequencing error rates. Herein, we propose the Realignment-based Mobile Element insertion detection Tool for Long read (rMETL). Benchmarking results of simulated and real datasets demonstrate that rMETL enables to handle the complex signals to discover MEIs sensitively. It is suited to produce high-quality MEI callsets in many genomics studies.

Availability and implementation

rMETL is available from https://github.com/hitbc/rMETL.

Supplementary information

Supplementary data are available at Bioinformatics online.
Biomolecular Reaction and Interaction Dynamics Global Environment (BRIDGE)
Authors: Senapathi Tharindu , Bray Simon , Barnett Christopher B , Grüning Björn , Naidoo Kevin J
Published: February 2019

Motivation

The pathway from genomics through proteomics and onto a molecular description of biochemical processes makes the discovery of drugs and biomaterials possible. A research framework common to genomics and proteomics is needed to conduct biomolecular simulations that will connect biological data to the dynamic molecular mechanisms of enzymes and proteins. Novice biomolecular modelers are faced with the daunting task of complex setups and a myriad of possible choices preventing their use of molecular simulations and their ability to conduct reliable and reproducible computations that can be shared with collaborators and verified for procedural accuracy.

Results

We present the foundations of Biomolecular Reaction and Interaction Dynamics Global Environment (BRIDGE) developed on the Galaxy platform that makes possible fundamental molecular dynamics of proteins through workflows and pipelines via commonly used packages, such as NAMD, GROMACS and CHARMM. BRIDGE can be used to set up and simulate biological macromolecules, perform conformational analysis from trajectory data and conduct data analytics of large scale protein motions using statistical rigor. We illustrate the basic BRIDGE simulation and analytics capabilities on a previously reported CBH1 protein simulation.

Availability and implementation

Publicly available at https://github.com/scientificomputing/BRIDGE and https://usegalaxy.eu

Supplementary information

Supplementary data are available at Bioinformatics online.
Direct-Acting Antiviral Treatment Failure Among Hepatitis C and HIV–Coinfected Patients in Clinical Care
Authors: Rossi Carmine , Young Jim , Martel-Laferrière Valérie , Walmsley Sharon , Cooper Curtis , Wong Alexander , Gill M John , Klein Marina B ,   The Canadian Co-Infection Cohort Investigators, Barrett Lisa , Cohen Jeff , Conway Brian , Cooper Curtis , Côté Pierre , Cox Joseph , Gill John , Haider Shariq , Hull Mark , Klein Marina , Montaner Julio , Moodie Erica , Pick Neora , Rachlis Anita , Rouleau Danielle , Sadr Aida , Sanche Steve , Sandre Roger , Tyndall Mark , Vachon Marie-Louise , Walmsley Sharon , Wong Alex
Published: February 2019

Background

There are limited data on the real-world effectiveness of direct-acting antiviral (DAA) treatment in patients coinfected with hepatitis C virus (HCV) and HIV—a population with complex challenges including ongoing substance use, cirrhosis, and other comorbidities. We assessed how patient characteristics and the appropriateness of HCV regimen selection according to guidelines affect treatment outcomes in coinfected patients.

Methods

We included all patients who initiated DAA treatment between November 2013 and July 2017 in the Canadian Co-Infection Cohort. Sustained virologic response (SVR) was defined as an undetectable HCV RNA measured between 10 and 18 weeks post-treatment. We defined treatment failure as virologic failure, relapse, or death without achieving SVR. Bayesian logistic regression was used to estimate the posterior odds ratios (ORs) associated with patient demographic, clinical, and treatment-related risk factors for treatment failure.

Results

Two hundred ninety-five patients initiated DAAs; 31% were treatment-experienced, 29% cirrhotic, and 80% HCV genotype 1. Overall, 92% achieved SVR (263 of 286, 9 unknown), with the highest rates in females (97%) and lowest in cirrhotics (88%) and high-frequency injection drug users (89%). Many patients (38%) were prescribed regimens that were outside current clinical guidelines. This did not appreciably increase the risk of treatment failure—particularly in patients with genotype 1 (prior odds ratio [OR], 1.5; 95% credible interval [CrI], 0.38–6.0; posterior OR, 1.0; 95% CrI, 0.40–2.5).

Conclusions

DAAs were more effective than anticipated in a diverse, real-world coinfected cohort, despite the use of off-label, less efficacious regimens. High-frequency injection drug use and cirrhosis were associated with an increased risk of failure.
Successful Implementation of an Antibiotic Stewardship Program in an Academic Dental Practice
Authors: Gross Alan E , Hanna Danny , Rowan Susan A , Bleasdale Susan C , Suda Katie J
Published: February 2019

Background

Most antibiotic use in the United States occurs in the outpatient setting, and 10% of these prescriptions are generated by dentists. The development of comprehensive antibiotic stewardship programs (ASPs) in the dental setting is nascent, and therefore we describe the implementation of a dental ASP.

Methods

A collaborative team of dentist, pharmacist, and physician leaders conducted a baseline needs assessment and literature evaluation to identify opportunities to improve antibiotic prescribing by dentists within Illinois’ largest oral health care provider for Medicaid recipients. A multimodal intervention was implemented that included patient and provider education, clinical guideline development, and an assessment of the antibiotic prescribing rate per urgent care visit before and after the educational interventions.

Results

We identified multiple needs, including standardization of antibiotic prescribing practices for patients with acute oral infections in the urgent care clinics. A 72.9% decrease in antibiotic prescribing was observed in urgent care visits after implementation of our multimodal intervention (preintervention urgent care prescribing rate, 8.5% [24/283]; postintervention, 2.3% [8/352]; P < .001).

Conclusions

We report the successful implementation of a dental ASP that is concordant with the Centers for Disease Control and Prevention Core Elements of Antibiotic Stewardship in the Outpatient Setting. Our approach may be adapted to other dental practices to improve antibiotic prescribing.
Effect of harvest method and ammoniation of baled corn residue on intake and digestibility in lambs
Authors: Conway Ashley C , King Tasha M , Jolly-Breithaupt Melissa L , MacDonald Jim C , Klopfenstein Terry J , Drewnoski Mary E
Published: February 2019

To determine the effect of harvest method and ammoniation on both in vivo and in vitro digestibility of corn residue, six corn residue treatments consisting of three different harvest methods either with or without anhydrous ammonia chemical treatment (5.5% of dry matter [DM]) were evaluated. The harvest methods included conventional rake-and-bale (CONV) and New Holland Cornrower with eight rows (8ROW) or two rows (2ROW) of corn stalks chopped into the windrow containing the tailings (leaf, husk, and upper stem) from eight rows of harvested corn (ammoniated bales of each harvest method resulted in treatments COVAM, 8RAM, and 2RAM). Nine crossbred wether lambs (49.2 ± 0.5 kg BW) were fed 64.2% corn residue, 29.8% wet corn gluten feed, 3.3% smooth-bromegrass hay, and 2.8% mineral mix (DM basis) in a 9 × 6 Latin rectangle metabolism study with a 3 × 2 factorial treatment to measure total tract disappearance. Six 21-d periods consisted of 14-d adaptation and 7-d total fecal collection, and lambs were fed ad libitum (110% of the previous day’s DM intake [DMI]) during days 1 to 12 and reduced to 95% of ad libitum intake for days 13 to 21. There was a harvest method by ammoniation interaction (P < 0.01) for ad libitum DMI (days 7 to 11). Ammoniation increased (P < 0.01) intake across all harvest methods, where 2RAM DMI was 4.1%, COVAM was 3.6%, and 8RAM was 3.1%, which were all different (P < 0.01) from each other, but all untreated residues were consumed at 2.6% of BW (P ≥ 0.92) regardless of harvest method. There were no interactions (P > 0.34) between harvest method and ammoniation for any total tract or in vitro digestibility estimate. Harvest method affected (P < 0.04) DM, neutral detergent fiber (NDF), and acid detergent fiber (ADF) digestibility, where 2ROW was greater than both CONV and 8ROW, which did not differ. The organic matter (OM) digestibility (P = 0.12) and digestible energy (DE; P = 0.30) followed the same numerical trend. Both in vitro DM digestibility (IVDMD) and in vitro OM digestibility (IVOMD) of the residue were affected (P < 0.01) by harvest method, with 2ROW being greater (P < 0.01) than both CONV and 8ROW. For IVDMD, 8ROW was not (P = 0.77) different from CONV, but 8ROW IVOMD was lower (P = 0.03) than CONV. Ammoniation improved (P < 0.01) DM, OM, NDF, and ADF digestibility of all harvest methods, resulting in a 26% increase (P < 0.01) in DE due to ammoniation. Similar digestibility improvements were observed in vitro with ammoniation improving IVDMD and IVOMD by 23% and 20%, respectively. Both selective harvest methods and ammoniation can improve the feeding value of baled corn residue.