bluuebunny/crossref_metadata_2025 huggingface dataset:
A SYSTEMATIC REVIEW ON DIETARY APPROACHES TO STOP HYPERTENSION (DASH) TO CONTROL RAISED BLOOD PRESSURE AMONG HYPERTENSIVE PATIENTS
Authors: Khan Subhana Akber , Hafeez Assad , Sikander Siham , Khan Abdul Wali , Yasmin Rizwana
Published: March 2020

Introduction: Hypertension is a widely recognized public health problem worldwide. Its further complications lead to cardiovascular diseases, stroke, retinal and renal diseases. DASH diet has been recommended to control raised blood pressure among hypertensive patients. However; limited evidence exists for it in Asian countries. This study aimed to review published research articles on DASH diet for hypertension control. Methods: Studies on hypertension and DASH diet (N=54) were searched using PubMed Central from 2012 to 2019 including all countries. The search strategy consisted of keywords "hypertension OR raised blood pressure OR blood pressure" and "Dietary Approaches to Stop Hypertension OR DASH diet". Whereas; no limitation was used for searching the literature and further references of the relevant studies were also analyzed. Full text articles of 31 researches were retrieved and analyzed for this review article. Results: Findings of this review suggests that DASH diet is significantly effective in lowering the blood pressure as well as for prevention of cardiovascular diseases (CVDs). In addition, a low-sodium diet is beneficial for individuals and hypertensive patients in reducing CVD related events. However; evidence suggests that adherence to DASH diet for a longer duration is effective along with lifestyle modifications in the population. Conclusion: Consuming a DASH diet as recommended can be a useful preventive measure to reduce blood pressure. Country-specific dietary recommendations are thus required. DASH diet along with pharmacological therapy and lifestyle modifications are proven to be effective. Further, longitudinal studies establishing temporal associations between consumption of DASH diet and its effect on blood pressure will be essential for clinical and public health practice.
GANGGUAN BERBAHASA AKIBAT ALAT UCAP PADA ANAK USIA 9 TAHUN
Authors: Mulyana Salsabila Delaria
Published: March 2020

Bahasa anak adalah bahasa yang sangat luas karena pada masa ini anak dibebaskan menyerap semua informasi tanpa ada penyaringan yang bersifat wajib. Banyak orang dewasa yang terpesona melihat kemampuan anak dalam pemerolehan bahasa yang begitu luas. Semua informasi bisa diperoleh anak darimanapun. Akan tetapi dalam proses pemerolehan bahasa, tidak semua anak dapat menerimanya dengan sempurna. Terdapat beberapa anak yang memiliki gangguan berbahasa dalam proses belajarnya. Salah satu penyebab gangguan berbahasa pada anak adalah akibat tidak sempurnanya alat ucap yang dimiliki. Penelitian ini akan membahas penyebab gangguan berbicara pada anak usia 9 tahun akibat alat ucap. Tujuan penelitian ini adalah untuk mengetahui dan memperbaiki gangguan berbahasa yang terjadi akibat alat ucap pada anak. Metode penelitian ini adalah deskriptif kualitatif dengan objek penelitian fokus kepada anak laki-laki usia 9 tahun yang memiliki gangguan berbahasa. Data yang diteliti berbentuk audio, video beserta transkrip percakapan antara peneliti dan objek sekaligus kawan tutur dalam percakapan tersebut. Adapun hasil penelitiannya yaitu (1) Gangguan berbahasa pada anak usia 9 tahun yang diucapkan oleh alat ucap adalah ketidaksempurnaan pada bagian laringal, (2) Faktor lingkungan juga dapat menentukan bagaimana alat ucap dapat menjadi gangguan atau sebaliknya yang mendukung proses pemerolehan bahasa.
BENTUK DAN FUNGSI TINDAK TUTUR DIREKTIF PADA TERJEMAHAN ALQURAN BERBAHASA INDONESIA
Authors: Ahya Akhmad Sauqi
Published: March 2020

Penelitian ini bertujuan menganalisis bentuk dan fungsi tindak tutur direktif dalam terjemahan Alquran berbahasa indonesia. Penelitian ini mengunkan jenis penelitian deskriptif kualitatif. Sumber data pada penelitian iniadalah terjemahan alquran berbahasa indonesia Teknik pengumpulan data dalam penelitian menggunakan teknik simak, teknik rekam, dan teknik catat. Hasil penelitian adalah bentuk tuturan kalimat langsung dan tidak langsung Fungsi tindak tutur direktif yang ditemukan meliputi fungsi: memerintah, mendorong, mengecam dan melarang
Tingginya Mutu Pelayanan Keperawatan Berpengaruh terhadap Kepuasan Pasien di BLUD RS Benyamin Guluh Kolaka
Authors: Nasus Evodius , Tulak Grace Tedy
Published: March 2020

Hospitals as health service providers are expected to always prioritize patient satisfaction through improving the quality of services performed. One indicator to assess the quality of health services is to measure the level of satisfaction of patients who are recipients of health services. This research aims to analyze the effect of the quality of nursing services with patient satisfaction at BLUD Benyamin Guluh Kolaka Hospital. The research method used was an analytic survey with a cross-sectional approach. The population and sample were 75 patients in the internal and surgical rooms which were obtained by the accidental sampling method. The results result showed that significantly the high quality of nursing services can affect patient satisfaction (p=0.000 < p=0.05). The conclusion of this study is that the higher the quality of nursing services, the more positive impact on satisfaction felt by patients otherwise.
Faktor yang Mempengaruhi Kualitas Tidur Mahasiswa Fakultas Kedokteran Universitas Halu Oleo
Authors: Haryati Haryati , Yunaningsi Siti Patma , RAF Junuda
Published: March 2020

Sleep is one of the basic human needs that can affect the quality of life and health. Poor sleep quality can result in decreased physiological and psychological health. Purpose: This study aims to determine the factors that affect the sleep quality of medical students of Halu Oleo University. The study design was using quantitative research with a cross-sectional approach. The sample of this study were 174 medical students of Halu Oleo University in the second and third academic years. The sampling technique was using Proportional Random Sampling. Data on sleep quality obtained by using the Pittsburgh Sleep Quality Index (PSQI) questionnaire and data analysis was using a chi-square statistical test with a confident interval of 95% (alpha = 0.05). The median age of respondents was 20 (range 18-21) years and 127 (73%) of the participants were females. A student with high physical activity was 112 (64.4%), sleep pattern in the good category as much as 98 (56.3%), and students with emotional stress in the low category were 120 (69.0%). More than half of students (89.1%) have poor sleep quality. The bivariate analysis showed that the factors that affect sleep quality were sleep patterns (p-value = 0.019) and emotional stress (p-value = 0.021). Student physical activity was not statistically affected sleep quality (p-value = 0.519). The sleep quality of medical students of Halu Oleo university were affected by sleep patterns and emotional stress.
Korelasi Usia Metabolik terhadap Indeks Massa Tubuh
Authors: Yuliani Ni Nyoman Sri , Trinovita Elsa
Published: March 2020

Excessive fat accumulation in the body causes an increase in Body Mass Index (BMI). Increased BMI and comorbidities affect the metabolic rate. Metabolic age was influenced by the individual metabolic rate. The purpose of this study was to determine the description of metabolic age to BMI increasement. This cross-sectional study used a purposive sampling method to obtain 82 male and female subjects. Subjects were measured for BMI and metabolic age. Collected data was analyzed univariately and bivariate correlatively. The result showed a significant correlation between metabolic age and BMI (p = 0,001) with r = 0,812. The conclusion of this study is the increase in BMI, the higher the metabolic age.
Hubungan Stress dengan Kadar Gula Darah Sewaktu pada Mahasiswa Rekognisi Pembelajaran Lampau (RPL) di Poltekkes Kemenkes Palangka Raya
Authors: Natalansyah Natalansyah , Sari Debora Kartika , Kasuma Wijaya Atmaja
Published: March 2020

Stress is the condition of an individual who experiences excessive emotional demands, a time problem that makes it difficult to manage efficiently all aspects of life (Richard, 2010). In someone with mild and moderate levels of stress will experience changes in blood sugar levels. This study examines stress levels and random blood sugar levels in nursing students. The purpose of this study was to identify respondent characteristics, stress levels, random blood sugar levels and the relationship between stress levels and random blood sugar levels at the health Polytechnic of Palangka Raya. The research method respondents (f = 39) was assessed using the Perceived Stress Scale -10 questionnaire to measure stress level. Glucometer was used for checking the random blood sugar levels. Chi-Square test was used to determine the relationship between the two variables, results from 39 respondents who had moderate stress levels, 27 respondents had high blood sugar levels of 23 (85.2%) and mild stress levels as many as 12 respondents with normal blood sugar levels 7 (58.3); There is a correlation between stress and random blood sugar levels in Secondary Learning Recognition (RPL) students of the Nursing Department Class II at Health Polytechnic of Palangka Raya with ? value <0.005.
Pengaruh Pemahaman Informasi KB dan Tingkat Ekonomi Keluarga terhadap Pemilihan Pemakaian Alat Kontrasepsi di Provinsi Kalimantan Tengah
Authors: Putra Chandra Anugrah , Jailani Muhammad , Qudsiyah Ummi , Permadi Ade Salahuddin
Published: March 2020

This study aims to determine the magnitude of the influence of understanding family planning information and the economic level of the family on the choice of contraceptive use in women of childbearing age in Province Central Kalimantan. The research design used was an explanatory research design with a quantitative approach to post-facto models. The study population was 587 women of childbearing age in Central Kalimantan province and the sampling technique used was the total sampling technique. The analysis technique uses multiple linear regression analysis techniques with a significant level (p) smaller or equal to 0.05 (p <0.05) and smaller or equal to 0.01 (p <0.01). The results showed that the direct effect between the understanding of family planning information on the choice of contraceptive use was significant (p <0.01), with a value of � = 1.989; p <0.05. At the family economic level, the choice of contraceptive use was significant (p <0.01), with a value of � = -,972; p <0.01. The conclusion of the first research is proven that understanding family planning information has a significant effect on the choice of contraceptive use in women of childbearing age in the province of Central Kalimantan, the second is proven that the family economic level has a significant effect on the choice of contraceptive use in women of childbearing age in the province of Central Kalimantan. Research Suggestions.
Pengaruh Perubahan Ritme Sirkadian terhadap Marker Inflamasi pada Pedagang Pasar Subuh di Kota Palangka Raya
Authors: Ardina Rinny , Purbayanti Dwi
Published: March 2020

Dawn market traders in Pasar Seram Palangka Raya City with sleep deprivation and alteration of sleep pattern has the potential risk of circadian rhythm disruption. Circadian rhythm disruption is the beginning of various chronic diseases such as coronary heart disease. One of the inflammation markers that can be used to assess the onset of atherosclerosis and coronary heart disease is the platelet profile (platelet count, mean platelet volume (MPV), platelet distribution width (PDW) and plateletcrit (PCT)). This study aimed to describe the effect of circadian rhythm disruption of inflammation marker as a platelet profile in dawn market traders in Pasar Seram Palangka Raya City. The descriptive observational method with a cross-sectional design was used in this study. Samples obtained as many as 100 people using purposive sampling technique. The examination of the platelet profile was done by an automated method using a hematology analyzer. The results showed, there was 6% with high platelet count and it only in women. Whereas for platelet indices in men, there was 6% with high MPV, 74% with high PCT, and 10% with low PCT. In women, there was 84% with high PCT and 6% with low PCT (6%). The result showed there were inflammation and accumulation of platelets as a result of circadian rhythm disruption in dawn market traders.
Analisis Pengaruh Penyimpanan terhadap Kadar Vitamin C pada Cabai Rawit (Capsicum frutuscens L) dan Cabai Merah Besar (Capsicum annum L) dengan Metode Spektrofotometri
Authors: Handayani Rezqi , Qamariah Nurul , Rizky Tri Agung
Published: March 2020

Chili is one of the fruits that contain vitamin C in a very large number. Vitamin C is one of the vitamins that is needed but cannot be synthesized in the body and has free radical antidote properties which will slow down the oxidation process that occurs in the body. One of the characteristics of vitamin C is a compound that is very easily oxidized due to the influence of heat, metal, and light so that in storage it needs special treatment to keep the levels low. One of the habits of the people in storing chili is in cold temperatures. This way trusted to maintain the condition of chili to always be fresh. But it is not yet known whether these conditions can guarantee vitamin C levels in them. Theoretically, the optimal storage for chili is at low temperatures between 2-15o C with humidity of 90-95% so that the chili remains fresh for � 20 days. This research is to find out whether or not there is an influence between storage time on vitamin C levels in cayenne pepper and red. The research method used was quantitative analysis by measuring vitamin C levels in chili using a spectrophotometric instrument. The storage day indicator used in this study is the first, second, fourth and sixth day and the temperature used is 4oC. The results of the study for vitamin C levels in fresh cayenne pepper were 88.19 � 1.39 mg/g, at two days storage was 82.04 � 1.34 mg/g, at four days storage was 78.43 � 1.02 mg/g and at six days storage was 78.17 � 2.05 mg/g. The results of the study for vitamin C levels in fresh red chili were 81.54 � 0.51 mg/g, at two days storage was 74.39 � 0.89 mg/g, at four days storage was 42.49 � 0.77 mg/g and at six days storage was 42.83 � 0.17 mg/g. Based on research that has been done on cayenne pepper and large red chili it can be concluded, that with 4oC temperature in storage for 2 days, 4 days and 6 days in the refrigerator the levels of vitamin C are not well maintained.
Seroprevalensi Hepatitis B pada Pemulung Sampah di Kota Palangka Raya
Authors: Suratno Suratno , Sartika Fera
Published: March 2020

Hepatitis B is a hepatitis B virus (HBV) infection which can exacerbate the liver and cause acute and chronic disease. The most susceptible group to hepatitis B transmission is waste pickers. This study aimed to determine: (1) the level of Hepatitis B virus infection among waste pickers in several temporary waste shelters in Palangka Raya, and (2) risk factors for hepatitis B virus infection in waste pickers in several temporary waste shelters in Palangka Raya. The observational analytic study using a cross-sectional study design was used in this research. The purposive sampling technique was carried out to involve 32 waste pickers in Palangka Raya. Examination of hepatitis B screening through HBsAg test to waste scavenger blood samples using the Rapid Test method. The results showed that the rate of hepatitis B infection based on positive HBsAg examination was 3.1% of respondents. Risk factors for transmission or exposure to hepatitis B that are directly related to the activity of garbage scavengers are not using protective equipment (PPE) gloves and bare hands waste collection, respectively 3.6% and 6.7%
Survival Analisis Suhu Tubuh pada Pasien Diare yang Diberikan Vitamin D
Authors: Usali R Sutrimo , Darmawan Endang , Kurniawan Nurcholid Umam
Published: March 2020

Diarrhea is a disease that attacks the digestive system, and most caused by microorganisms (bacteria and viruses) Diarrhea is still the second largest cause of death in the world after pneumonia and is still a public health problem in developing countries like Indonesia. Vitamin D is a potential mediator in regulating the immune system to become the body's defense against infection. This study aims to determine the effectiveness of vitamin D based on body temperature parameters. The study was conducted using a double-blind randomized clinical trial experimental research design, in which researchers conducted clinical trials in the control group (placebo) and there was a comparison group (vitamin D adjuvant). Vitamin D provides a better chance of survival as well as a better chance of a decrease in body temperature compared to patients who do not get vitamin D therapy as an adjuvant (additional). Significant results occurred on days 3, 5 and 6.
Aktivitas Antioksidan dan Nilai SPF (Sun Protection Factor) Ekstrak Etanol Buah Pepaya (Carica papaya L.) yang Diperoleh dari Simplisia dan Buah Segar
Authors: Rakhmatullah Aditya Noviadi , Sugihartini Nining , Susanti Hari
Published: March 2020

Papaya contains vitamin C and beta-carotene which are useful as antioxidants and can be used as a sunscreen. The content of the active substance is affected by the type of raw material. This study aims to determine the antioxidant activity and SPF value of extracts obtained from simplicia and fresh fruit. Extracts obtained from simplicia and fresh fruit were determined antioxidant activity by DPPH method and SPF values by spectrophotometric method. The results showed that the antioxidant activity of papaya extract obtained from simplicia had IC50 values smaller than papaya extract obtained from fresh fruit, whereas the papaya extract obtained from simplicia had IC50 values of 175 �g / mL and the papaya extract obtained from fruit fresh is 209 �g / mL. While in the sunscreen test, the SPF value of papaya extract obtained from simplicia is greater than the papaya extract obtained from fresh fruit. SPF value of papaya extract obtained from simplicia is 37, while papaya extract obtained from fresh fruit is 35. The conclusion from this study is papaya extract extracted by the drying process of the initial material (simplicia) has antioxidant activity and SPF values that are more optimal than papaya extracts extracted without going through a drying process first (fresh fruit).
Pengaruh Pemberian MP-ASI terhadap Tingkat Morbiditas Anak di Indonesia (Analisis Data SDKI Tahun 2017)
Authors: Nurhalina Nurhalina , Purbayanti Dwi , Ardina Rinny , Fitriyanto Muhammad
Published: March 2020

The results of the 2017 IDHS show that the level of child morbidity in Indonesia is still quite high with the main symptoms found are ARI, diarrhea, and fever. Meanwhile, 43% of infants do not get breast milk, 48% do not get exclusive breastfeeding and 60% of children receive food not in accordance with WHO recommendations. The purpose of this study was to determine the effect of feeding patterns on the level of child morbidity in Indonesia by analyzing the IDHS data in 2017. The method was a cross-sectional study. The population was women of childbearing age realized in the 2017 IDHS and sample who had children aged = 2 years and having sick during the survey period. The sample was excluded if the children had died or lived with other people and had a history of birth weight <2500 gram. Data analysis using chi-square test and multivariate analysis with logistic regression. The results showed that the pattern of giving complimentary food (p-value = 0.033 and OR=1.214) influenced the level of child morbidity in Indonesia.
Mast-Cell Degranulation Induced by Physical Stimuli Involves the Activation of Transient-Receptor-Potential Channel TRPV2
Authors: ZHANG D. , SPIELMANN A. , WANG L. , DING G. , HUANG F. , GU Q. , SCHWARZ W.
Published: March 2020

A characteristic of mast cells is the degranulation in response to various stimuli. Here we have investigated the effects of various physical stimuli in the human mast-cell line HMC-1. We have shown that HMC-1 express the transient receptor potential channels TRPV1, TRPV2 and TRPV4. In the whole-cell patch-clamp configuration, increasing mechanical stress applied to the mast cell by hydrostatic pressure (–30 to –90 cm H2O applied via the patch pipette) induced a current that could be inhibited by 10 µM of ruthenium red. This current was also inhibited by 20 µM SKF96365, an inhibitor that is among TRPV channels specific for the TRPV2. A characteristic of TRPV2 is its activation by high noxious temperature; temperatures exceeding 50 °C induced a similar ruthenium-red-sensitive current. As another physical stimulus, we applied laser light of 640 nm. Here we have shown for the first time that the application of light (at 48 mW for 20 min) induced an SKF96365-sensitive current. All three physical stimuli that led to activation of SKF96365-sensitive current also induced pronounced degranulation in the mast cells, which could be blocked by ruthenium red or SKF96365. The results suggest that TRPV2 is activated by the three different types of physical stimuli. Activation of TRPV2 allows Ca2+ ions to enter the cell, which in turn will induce degranulation. We, therefore, suggest that TRPV2 plays a key role in mast-cell degranulation in response to mechanical, heat and red laser-light stimulation.
Allopurinol Intake Does Not Modify the Slow Component of V O2 Kinetics and Oxidative Stress Induced by Severe Intensity Exercise
Authors: OLEK R. A. , SAFRANOW K. , JAKUBOWSKA K. , OLSZEWSKA M. , CHLUBEK D. , LASKOWSKI R.
Published: March 2020

The aim of this study was to test the hypothesis that allopurinol ingestion modifies the slow component of V O2 kinetics and changes plasma oxidative stress markers during severe intensity exercise. Six recreationally active male subjects were randomly assigned to receive a single dose of allopurinol (300 mg) or a placebo in a double-blind, placebo-controlled crossover design, with at least 7 days washout period between the two conditions. Two hours following allopurinol or placebo intake, subjects completed a 6-min bout of cycle exercise with the power output corresponding to 75 % V O2max. Blood samples were taken prior to commencing the exercise and then 5 minutes upon completion. Allopurinol intake caused increase in resting xanthine and hypoxanthine plasma concentrations, however it did not affect the slow component of oxygen uptake during exercise. Exercise elevated plasma inosine, hypoxanthine, and xanthine. Moreover, exercise induced a decrease in total antioxidant status, and sulfhydryl groups. However, no interaction treatment x time has been observed. Short term severe intensity exercise induces oxidative stress, but xanthine oxidase inhibition does not modify either the kinetics of oxygen consumption or reactive oxygen species overproduction.
Cardiorenal Syndrome in Hypertensive Rats: Microalbuminuria, Inflammation and Ventricular Hypertrophy
Authors: MOUBARAK M. , JABBOUR H. , SMAYRA V. , CHOUERY E. , SALIBA Y. , JEBARA V. , FARÈS N.
Published: March 2020

The aim of our study was to evaluate a possible association between microalbuminuria (MA), several low-grade inflammation factors and left ventricular hypertrophy (LVH) by using a pharmacological approach. This may provide new insights into the pathophysiologic mechanisms of the cardiorenal syndrome (CRS) linking early renal impairment with elevated cardiovascular risk. Two kidney-one clip (2K-1C) renovascular hypertension was induced in 24 male Wistar rats (220-250 g). After the development of hypertension, rats were divided into four groups: 2K-1C (untreated), calcium channel blocker (amlodipine-treated), angiotensin receptor blocker (losartan-treated) and peripheral vasodilator (hydralazine-treated), which were treated for 10 weeks. Rats in the 2K-1C group had all developed hypertension, a significant increase in plasma levels of tumor necrosis factor alpha (TNF-α), interleukin 6 (IL-6), brain natriuretic peptide (BNP) and C-reactive protein (CRP). Moreover MA and creatininaemia underwent a significant increase. Under treatment decreases were observed in systolic blood pressure (SBP), TNF-α, CRP, IL-6, BNP concentrations and creatininaemia. These results were related to the absence of MA which was significantly associated with reductions in cardiac mass and hypertrophy markers (BNP and β-MHC gene expression) as well as renal interstitial inflammation. In conclusion, our results suggest that the reduction of MA is correlated with the decrease of the inflammatory components and seems to play an important role in protecting against cardiac hypertrophy and renal injury.
Chronic Cigarette Smoking Alters Circulating Sex Hormones and Neuroactive Steroids in Premenopausal Women
Authors: DUŠKOVÁ M. , ŠIMŮNKOVÁ K. , HILL M. , VELÍKOVÁ M. , KUBÁTOVÁ J. , KANCHEVA L. , KAZIHNITKOVÁ H. , HRUŠKOVIČOVÁ H. , POSPÍŠILOVÁ H. , RÁCZ B. , SALÁTOVÁ M. , CIRMANOVÁ V. , KRÁLÍKOVÁ E. , STÁRKA L. , PAŘÍZEK A.
Published: March 2020

Chronic smoking alters the circulating levels of sex hormones and possibly also the neuroactive steroids. However, the data available is limited. Therefore, a broad spectrum of free and conjugated steroids and related substances was quantified by GC-MS and RIA in premenopausal smokers and in age-matched (38.9±7.3 years of age) non-smokers in the follicular (FP) and luteal phases (LP) of menstrual cycle (10 non-smokers and 10 smokers, in the FP, and 10 non-smokers and 8 smokers in the LP). Smokers in both phases of the menstrual cycle showed higher levels of conjugated 17-hydroxypregnenolone, 5α-dihydroprogesterone, conjugated isopregnanolone, conjugated 5α-pregnane-3β,20α-diol, conjugated androstenediol, androstenedione, testosterone, free testosterone, conjugated 5α-androstane-3α/β,17β-diols, and higher free testosterone index. In the FP, the smokers exhibited higher levels of conjugated pregnenolone, progesterone, conjugated pregnanolone, lutropin, and a higher lutropin/follitropin ratio, but lower levels of cortisol, allopregnanolone, and pregnanolone. In the LP, the smokers exhibited higher levels of free and conjugated 20α-dihydropregnenolone, free and conjugated dehydroepiandrosterone, free androstenediol, 5α-dihydro-testosterone, free and conjugated androsterone, free and conjugated epiandrosterone, free and conjugated etiocholanolone, 7α/β-hydroxy-dehydroepiandrosterone isomers, and follitropin but lower levels of estradiol and sex hormone binding globulin (SHBG) and lower values of the lutropin/follitropin ratio. In conclusion, chronic cigarette smoking augments serum androgens and their 5α/β-reduced metabolites (including GABAergic substances) but suppresses the levels of estradiol in the LP and SHBG and may induce hyperandrogenism in female smokers. The female smokers had pronouncedly increased serum progestogens but paradoxically suppressed levels of their GABA-ergic metabolites. Further investigation is needed concerning these effects.
Distribution of Mean Cycle Length in Cavo-Tricuspid Isthmus Dependent Atrial Flutter
Authors: HAVRÁNEK Š. , ŠIMEK J. , ŠŤOVÍČEK P. , WICHTERLE D.
Published: March 2020

Although cycle length (CL) constitutes a fundamental descriptor of any arrhythmia, there is not larger study describing mean CL in electrophysiologically confirmed cavo-tricuspid isthmus (CTI)-dependent atrial flutter (AFL). We analyzed retrospectively digital recordings of 121 patients (98 men; age 64±11 years) referred for radiofrequency ablation of persistent CTI-dependent AFL. Median of mean AFL CL was 240 ms (interquartile range (IQR) of 222-258 ms, overall range of 178-399 ms). The distribution of CL was not normal (Shapiro Wilk test, p<0.001). Both counterclockwise and clockwise (14.9 % of all cases) AFLs were comparable in their CL; 240 (IQR 222-258) ms vs. 234 (217-253) ms, respectively. AFL CL<200 ms and AFL CL<190 ms was noticed in 5 (4.1 %) and 3 cases (2.5 %), respectively. In multivariate regression analysis, age (increase by 6±3 ms per decade of age, p=0.036), treatment with specific antiarrhythmic drugs (increase by 11±6 ms, p=0.052) and the history of cardiac surgery (increase by 26±9 ms, p=0.004) were independently associated with AFL CL. In conclusions, the distribution of AFL CL is not normal. The prevalence of AFL with short CL is low. Short CL<200 ms does not rule out the CTI-dependent AFL, especially in young and otherwise healthy patients.
Might Cardiac Catheterization Influence Diurnal Rhythm of the Steroid Stress Hormones Secretion?
Authors: SKARLANDTOVÁ H. , BIČÍKOVÁ M. , NEUŽIL P. , MLČEK M. , HRACHOVINA V. , SVOBODA T. , MEDOVÁ E. , KUDLIČKA J. , DOHNALOVÁ A. , HAVRÁNEK Š. , KAZIHNÍTKOVÁ H. , MÁČOVÁ L. , VAŘEJKOVÁ E. , KITTNAR O.
Published: March 2020

Glucocorticoids (GCs) are steroid hormones produced by the adrenal cortex in reaction to stress stimuli. GCs production is not stable over a 24-hour period; the plasma concentration peaks in the morning (approximately upon awakening) and then the plasma levels decrease, reaching the nadir in the evening. In our experiments, the levels of cortisol, cortisone, DHEA and DHEAS were tested in young female pigs (n=23) during heart catheterization at two different day times (in the morning and in the afternoon). The non-parametric Mann-Whitney test for statistical analysis was used. We found only minimal statistical differences in studied markers between the morning and afternoon group (p>0.05). The absence of circadian variation in GCs levels could originate either at an early age of our experimental pigs, or in stressful conditions on the experiment day, or most likely the day before (e.g. social isolation, fasting, transport, and catheterization), respectively. We can conclude there is no difference in the stress load between morning and afternoon experiments, and therefore we can assume the stress load is not a limiting factor for the timing when catheterization should be preferably performed.
Comparison of the Effects of Ketamine-Dexmedetomidine and Sevoflurane-Sufentanil Anesthesia on Cardiac Biomarkers After Cardiac Surgery: An Observational Study
Authors: ŘÍHA H. , KOTULÁK T. , BŘEZINA A. , HESS L. , KRAMÁŘ P. , SZÁRSZOI O. , NETUKA I. , PIRK J.
Published: March 2020

Inhalational anesthetics have demonstrated cardioprotective effects against myocardial ischemia-reperfusion injury. Clinical studies in cardiac surgery have supported these findings, although not with the consistency demonstrated in experimental studies. Recent investigations have questioned the advantages of inhalational over intravenous anesthetics with respect to cardiac protection. Ketamine has been shown to be comparable with sufentanil, and has even demonstrated anti-inflammatory properties. Dexmedetomidine has been established as a sedative/anesthetic drug with analgesic properties, and has also demonstrated myocardial protective effects. In this retrospective observational study, the influence of ketamine-dexmedetomidine-based anesthesia (KET-DEX group; n=17) on the release of cardiac biomarkers was compared with that of sevoflurane-sufentanil-based anesthesia (SEVO group; n=21) in patients undergoing elective coronary artery bypass grafting. Compared with the SEVO group, the KET-DEX group exhibited significantly reduced cardiac troponin I (2.22±1.73 vs. 3.63±2.37 µg/l; P=0.02) and myocardial fraction of creatine kinase (CK-MB) levels (12.4±10.4 vs. 20.3±11.2 µg/l; P=0.01) on the morning of the first postoperative day. Furthermore, cardiac troponin I release, evaluated as the area under the curve, was significantly reduced in the KET-DEX group (32.1±20.1 vs. 50.6±23.2; P=0.01). These results demonstrate the cardioprotective effects of ketamine-dexmedetomidine anesthesia compared with those of sevoflurane-sufentanil anesthesia.
Acute Cadmium Exposure Causes Systemic and Thromboembolic Events in Mice
Authors: FAHIM M. A. , NEMMAR A. , DHANASEKARAN S. , SINGH S. , SHAFIULLAH M. , YASIN J. , ZIA S. , HASAN M. Y.
Published: March 2020

Cadmium (Cd), an environmental and industrial pollutant, poses a potential threat and affects many systems in human and animals. Although several reports on Cd toxicity were presented, the acute effect of Cd on systemic and thrombotic events was not reported so far. Cd (2.284 mg/kg) or saline (control) was injected intraperitoneally (ip), and the systemic parameters were assessed in mice. Compared to control group, acute intraperitoneal injection of Cd, in mice showed significant quickening of platelet aggregation (P<0.001) leading to pial cerebral thrombosis. Likewise, Cd exposure caused a significant increase in white blood cell numbers (P<0.05) indicating the occurrence of systemic inflammation. Also, alanine aminotransferase (ALT) (P<0.05) and creatinine (P<0.01) levels were both significantly increased. Interestingly, the superoxide dismutase activity was significantly decreased in Cd treated group compared to control group (P<0.001), suggesting the occurrence of oxidative stress. We conclude that the Cd exposure in mice causes acute thromboembolic events, oxidative stress and alter liver and kidney functions.
Exercise-Induced Muscle Damage Impairs Insulin Signaling Pathway Associated With IRS-1 Oxidative Modification
Authors: AOI W. , NAITO Y. , TOKUDA H. , TANIMURA Y. , OYA-ITO T. , YOSHIKAWA T.
Published: March 2020

Strenuous exercise induces delayed-onset muscle damage including oxidative damage of cellular components. Oxidative stress to muscle cells impairs glucose uptake via disturbance of insulin signaling pathway. We investigated glucose uptake and insulin signaling in relation to oxidative protein modification in muscle after acute strenuous exercise. ICR mice were divided into sedentary and exercise groups. Mice in the exercise group performed downhill running exercise at 30 m/min for 30 min. At 24 hr after exercise, metabolic performance and insulin-signaling proteins in muscle tissues were examined. In whole body indirect calorimetry, carbohydrate utilization was decreased in the exercised mice along with reduction of the respiratory exchange ratio compared to the rested control mice. Insulin-stimulated uptake of 2-deoxy-[3H]glucose in damaged muscle was decreased after acute exercise. Tyrosine phosphorylation of insulin receptor substrate (IRS)-1 and phosphatidyl-3-kinase/Akt signaling were impaired by exercise, leading to inhibition of the membrane translocation of glucose transporter 4. We also found that acute exercise caused 4-hydroxy-nonenal modification of IRS-1 along with elevation of oxidative stress in muscle tissue. Impairment of insulin-induced glucose uptake into damaged muscle after strenuous exercise would be related to disturbance of insulin signal transduction by oxidative modification of IRS-1.
Faktor Psikologi Sebagai Risiko Utama Ide Bunuh Diri pada Remaja di Kota Rengat Kabupaten Indragiri Hulu
Authors: Aulia Nur , Yulastri Yulastri , Sasmita Heppi
Published: March 2020

The high incidence of suicide, especially in this age group in which the teen years may be one time the vulnerability to suicidal ideation. Data from the National Commission for Child Protection in Indonesia of suicides that occurred with the youngest is 13 years old. This can occur due to various risk factors for teen suicide include psychological factors. This study aims to identify suicidal ideation relationship with risk factors for suicide in adolescents. Analytical research design was correlation with cross-sectional approach. Sample 365 adolescents with proportional random sampling. Data were analyzed using logistic regression test. The results showed the number of adolescent suicidal ideation is high. There was a relationship of psychological factors with suicidal ideation (p<0.005).. Psychological factors is most dominant contributing factor that trigger suicidal ideation. Parents and school should improve the counseling in order to identify the presence of suicidal ideation in adolescents earlier.

Keywords: adolescent; suicide idea; suicide risk factors; psychological factor

ABSTRAK

Tingginya angka kejadian bunuh diri khususnya pada kelompok usia remaja dimana masa remaja dapat menjadi salah satu waktu kerentanan terhadap ide bunuh diri. Data dari Komisi Nasional Perlindungan Anak di Indonesia dari kasus bunuh diri yang diterjadi dengan usia termuda adalah 13 tahun. Hal ini dapat terjadi karena berbagai faktor risiko bunuh diri pada remaja diantaranya adalah faktor psikologis. Penelitian ini bertujuan mengetahaui hubungan ide bunuh diri dengan faktor psikologi diantaranya depresi, kecemasa dan stres pada remaja. Desain penelitian analitik korelasi, pendekatan crosssection. Sampel 365 remaja dengan proposional random sampling. Data dianalisis menggunakan analisis regresi logistik. Hasil penelitian adalah sebagian besar remaja memiliki ide bunuh diri yang tinggi. Terdaoat hubungan signifikan antara faktor psikologis dengan ide bunuh diri (p<0,005). Setelah dilakukan analisis multivariate ditemukan bahwa faktor psikologis merupakan faktor yang dominan terhadap ide bunuh diri. Pencegahan kemunculan ide bunuh diri dapat dilakukan dengan peningkatan bimbingan konseling oleh orangtua dan sekolah sehingga ide bunuh diri dapat terdeteksi sejak dini.

Kata kunci: remaja; ide bunuh diri; faktor risiko bunuh diri; faktor psikologis
Progresivitas Perjanjian Daud
Authors: Harvijanto Andri
Published: March 2020

God's covenant with David is a core part of understanding God's plan for the development of the realization of the restoration of the state of Israel in the midst of the nation's deterioration. David became an ideal figure for kings in the eschatological period. In the future the promise will be fulfilled, renewed and expanded. Through the prophet Nathan a promise was given to David (2 Samuel 7: 12-17). Furthermore, the continuation of the David covenant can be understood through God's plan for the development of the realization of the restoration of the state of Israel in the midst of the nation's deterioration. David became an ideal figure for kings in the eschatological period.

 

AbstrakPerjanjian Allah dengan Daud merupakan bagian inti untuk memahami rencana Allah bagi perkembangan perwujudan pemulihan keadaan Israel di tengah-tengah keterpurukan bangsa. Daud menjadi figur yang ideal bagi raja di masa eskatologis..Di masa yang akan datang janji itu dipenuhi, diperbaharui dan diperluas. Melalui nabi Natan janji diberikan kepada Daud (2 Samuel 7:12-17). Selanjutnya kesinambungan perjanjian Daud dapat dipahami melalui rencana Allah bagi perkembangan perwujudan pemulihan keadaan Israel di tengah-tengah keterpurukan bangsa. Daud menjadi figur yang ideal bagi raja di masa eskatologis.
Anti-Cancer Activity of PAK4/NAMPT Inhibitor and Programmed Cell Death Protein-1 Antibody in Kidney Cancer
Authors: Trott Josephine F. , Abu Aboud Omran , McLaughlin Bridget , Anderson Katie L. , Modiano Jaime F. , Kim Kyoungmi , Jen Kuang-Yu , Senapedis William , Chang Hua , Landesman Yosef , Baloglu Erkan , Pili Roberto , Weiss Robert H.
Published: March 2020

Background

Kidney cancer (or renal cell carcinoma, RCC) is the sixth most common malignancy in the United States and is increasing in incidence. Despite new therapies, including targeted therapies and immunotherapies, most RCCs are resistant to treatment. Thus, several laboratories have been evaluating new approaches to therapy, both with single agents as well as combinations. Although we have previously shown efficacy of the dual PAK4/nicotinamide phosphoribosyltransferase (NAMPT) inhibitor KPT-9274, and the immune checkpoint inhibitors (CPI) have shown utility in the clinic, there has been no evaluation of this combination either clinically or in an immunocompetent animal model of kidney cancer.

Methods

In this study, we use the renal cell adenocarcinoma (RENCA) model of spontaneous murine kidney cancer. Male BALB/cJ mice were injected subcutaneously with RENCA cells and, after tumors were palpable, they were treated with KPT-9274 and/or anti–programmed cell death 1 (PDCD1; PD1) antibody for 21 days. Tumors were measured and then removed at animal euthanasia for subsequent studies.

Results

We demonstrate a significant decrease in allograft growth with the combination treatment of KPT-9274 and anti-PD1 antibody without significant weight loss by the animals. This is associated with decreased (MOUSE) Naprt expression, indicating dependence of these tumors on NAMPT in parallel to what we have observed in human RCC. Histology of the tumors showed substantial necrosis regardless of treatment condition, and flow cytometry of antibody-stained tumor cells revealed that the enhanced therapeutic effect of KPT-9274 and anti-PD1 antibody was not driven by infiltration of T cells into tumors.

Conclusions

This study highlights the potential of the RENCA model for evaluating immunologic responses to KPT-9274 and checkpoint inhibitor (CPI) and suggests that therapy with this combination could improve efficacy in RCC beyond what is achievable with CPI alone.
Semi-Markov analytical model for assessing the quality of the maintenance system and the state of electromechanical complexes
Authors: Kazhan Volodymyr , Stopkin Vasyl , Kotlyarova Ksenia , Yudin Alexander
Published: March 2020

Analysis of basic research. In practice, the EMC reliability indicators, in particular the failure rate, are time-varying quantities. In view of this, it is necessary to determine such periodicity values and maintenance volumes that would ensure the EMC maximum availability factor. The most adequate mathematical model for analyzing the technical state of EMC can be obtained using the apparatus of the theory of semi-Markov processes (PMF), the basis of which is an oriented graph of the basic states and transitions (GSP) of EMC during operation, which allows to formulate maintenance and maintenance strategies, the content of a separate strategy is determined a specific set of options for all states of EMC.The purpose of the article. Construction and study of a mathematical model of the EMC operation process to determine the optimal intervals and maintenance and repair strategies.The main research material. The solution to the first problem includes: building a model for the operation of the EMC; the derivation of the calculated ratio for the availability factor as a function of the technical condition of the EMC and the service station; obtaining an analytical formula for calculating optimal maintenance intervals.The paper proposes a combination of indicators ranked by importance in the linear programming problem, where the transfer time, which is a function of the SRT parameters and the technical condition of the EMC, is selected as the objective function, and the remaining indicators (readiness level, complex operation costs, and others) are taken into account in the form of restrictions. The result of solving this problem is a set of maintenance and repair options at each step of the operation of the EMC, which comprise the content of the optimal maintenance and repair strategy.Conclusions. An analytical relationship was obtained on the basis of the semi-Markov model of the operation process that allows one to calculate the optimal conditions for ensuring the availability factor of the periodicity of maintenance, which makes it possible to control the unsteady operation of the EMC, to obtain the necessary technical and economic quality indicators to build an adaptive ACS with the technical state of the EMC.
The study of dynamic processes in the hydraulic system of the roll clamp of a two-cone unwinder rolls pipe-welding unit 159-529
Authors: Mazur Igor , Sheludko Dmitry , Petrov Mykhailo
Published: March 2020

The work is devoted to the study of dynamic loads arising in the hydraulic system of the clamping mechanism of a roll of a two-cone unwinder of rolls of tubes of a pipe-welding unit 159-529. The operating experience of the two-cone unwinder has shown that one of its drawbacks is the unsatisfactory operation of the roll clamp hydraulic system, in which increased dynamic loads are observed. In the hydraulic system of the roll clamping mechanism, the executive hydraulic cylinder is located at a large distance from the pressure source, therefore, it uses long hydraulic lines. In transient modes of operation of a machine with such a hydraulic system, wave processes arise in it (unsteady fluid motion), which affect the quality of its functioning.Based on the analysis of mathematical models used in the practice of dynamic calculations of real hydraulic systems, it is shown that it is advisable to use a system of partial differential equations converted by a finite-difference method into a system as a mathematical model that takes into account the design and operation of the hydraulic system of the roll clamp mechanism of a two-cone unwinder ordinary differential equations with boundary conditions. This makes it possible to create a dynamic model that allows with high reliability to analyze the behavior of the hydraulic system of the mechanism of the clamping roll of a two-cone unwinder. During the implementation of the proposed mathematical model in the Simulink MATLAB software environment, a study was made of the operating modes of the hydraulic system of the roll clamping mechanism. As a result of the study, it was shown that in the hydraulic system of the roll clamping mechanism of a two-cone unwinder, dynamic loads occur at the end of the return stroke, which significantly exceed the permissible values.In order to reduce dynamic loads, a valve operating procedure with a response time of 0.16 seconds is proposed. This allows you to significantly reduce dynamic loads in the hydraulic system of the roll clamping mechanism by reducing the speed of movement of the hydraulic cylinders at the end of the carriage return stroke.
Исследование и разработка актуальных приемов, технологий и методик, применяемых при решении прикладных задач машинного обучения в целях предиктивного анализа
Authors: Ivchenko Rodion Anatoliyovych , Kupin Andriy Ivanovich
Published: March 2020

Произведено исследование актуальных приемов, технологий и методик, применяемых при решении прикладных задач машинного обучения, по материалам научных статей в высокорейтинговых журналах зарубежных исследователей, аналитических и обзорных заметок из открытых источников, а также технической документации и пресс-релизов технических и программных решений. Поиск новых методов выбора моделей, перекрестной проверки, эволюционного и аналитического подбора алгоритмов обучения представляет как научный, так и чисто практический интерес. Развитие технологий машинного обучения только ускорится в ближайшем будущем. В настоящее время мы наблюдаем прогресс в развитии методик автоматизированного поиска путей построения эффективных обучающихся моделей анализа данных, применимых ко многим практическим задачам интеллектуального анализа данных. В ходе обзора современных тенденций в машинном обучении нами выделены перспективные направления фундаментальных и прикладных исследований в данной области.
Спосіб визначення кількості рідини в нахиленій ємності на основі тріангуляції Делоне
Authors: Mazurenko Valeriy
Published: March 2020

Розглянуто задачу перерахунку даних вимірювання рівня та куту нахилу в кількість рідини всередині ємності. Запропоновано спосіб її вирішення на основі тріангуляції Делоне. Показано, що для практичних цілей даний спосіб є універсальним.
AUTOREGRESSION MODELS OF SPACE OBJECTS MOVEMENT REPRESENTED BY TLE ELEMENTS
Authors: Sarichev Aleksandr , Perviy Bogdan
Published: March 2020

The developed method, which is a modification of the previously developed methods for constructing autoregressive models, is used to simulate the motion of space objects in the time series of their TLE elements. The modeling system has been developed that includes: determining the optimal volume of training samples in modeling time series of TLE elements; determination of the autoregression order for each variable (TLE element); determination of the optimal structure and identification of the parameters of the autoregressive model for each variable; identification of patterns of evolution of the mean square error of autoregressive models in time based on the modeling of time series of TLE elements according to the principle of "moving interval".