bluuebunny/crossref_metadata_2025 huggingface dataset:
Bank Retreat Mechanisms Driven by Debris Flow Surges: A Parameterized Model Based on the Results of Physical Experiments
Authors: Wang Xi'an , Chen Jiangang , Chen Xiaoqing , Chen Huayong , Zhao Wanyu , Ruan Hechun , Wang Jinshui
Published: July 2024

Lateral erosion is a critical factor that influences the formation and amplification of debris flows. However, our understanding of the bank retreat process in debris flow channels is limited, which limits the evaluation of debris flow magnitudes and the prediction of their activity trends. Herein, we conduct physical experiments to investigate bank retreat mechanisms using five types of bank soil and multiple debris flow surges. The bank retreat process is categorized into two stages: toe cutting and bank collapse. Toe cutting is mainly caused by hydraulic erosion, bank collapse includes gravity erosion in the form of toppling failure. Notably, the bank retreat process exhibits a significant negative feedback loop. Bank erosion widens the channel bed, subsequently decreasing the flow depth. In turn, this reduction in flow depth mitigates bank erosion. Moreover, we discover a concise pattern in the complex coupling of hydraulic erosion and toppling failure: erosion efficiency is linearly and negatively correlated with the bed widening width. We develop a new parameterized model for describing the bank retreat process and provided empirical values for the model parameters. Furthermore, we observe that the initial erosion efficiency first increases and then decreases with an increase in the fine particle content of the bank soil. Additionally, we report a negative correlation between the maximum bed widening width and the fine particle content in the bank soil that follows a power function relationship.
Quantifying Earth's Topography: Steeper and Larger Than Projected in Digital Terrain Models
Authors: Voigtländer Anne , Rheinwalt Aljoscha , Tofelde Stefanie
Published: July 2024

Grid‐ or pixel‐based models, used across various scientific disciplines from microscopic to planetary scales, contain an unquantified error that bias our interpretation of the data. The error is produced by projecting 3D data onto a 2D grid. For Digital Terrain Models (DTMs) the projection error affects all slope‐dependent topographic metrics, like surface area or slope angle. Due to the proportionality of the error to the cosine of the slope, we can correct for it. We quantify the error and test the correction using synthetic landscapes for which we have analytical solutions of their metrics. Application to real‐world landscapes in California, reveal the systematic underestimation of surface area by up to a third, and mean slope angles by up to 10° in steep topography in current DTMs. Correcting projection errors allow for true estimates of surface areas and slope distributions enabling physics‐based models of surface processes at any spatial scale.
Observational Limitations to the Emergence of Climate Signals
Authors: Rivoire Louis , Linz Marianna , Li Jingyuan
Published: July 2024

Using model projections to study the emergence of observable climate signals presumes omniscient knowledge about the climate system. In reality, observational knowledge suffers from data quality and availability issues, for instance data gaps, changes in instrumentation, issues due to gridding and retrieval algorithms. Overlooking such deficiencies leads to misrepresentations of the time of emergence (ToE). We introduce a new definition of ToE that accounts for observational limitations, and show that significant corrections to the ToE may be necessary to achieve the same statistical confidence as would be afforded by omniscient knowledge. We also show how our method can inform future observational needs and observing systems design.
Flow‐Dependence of Ensemble Spread of Subseasonal Forecasts Explored via North Atlantic‐European Weather Regimes
Authors: Spaeth J. , Rupp P. , Osman M. , Grams C. M. , Birner T.
Published: July 2024

Atmospheric prediction at 2–6 weeks lead time (so‐called subseasonal‐to‐seasonal timescales) entails large forecast uncertainty. Here we investigate the flow‐dependence of this uncertainty during Boreal winter. We categorize the large‐scale flow using North Atlantic‐European weather regimes. First, we show that forecast uncertainty of near‐surface geopotential height (Z1000) and temperature (T2m) are strongly sensitive to the prevailing regime. Specifically, forecast uncertainty of Z1000 reduces over northern Europe following Greenland Blocking (enhanced predictability) due to a southward shifting eddy‐driven jet. However, due to strong temperature gradients and variable flow patterns, Greenland blocking is linked to increased forecast uncertainty of T2m over Europe (reduced predictability). Second, we show that forecast uncertainty of weather regimes is modulated via the stratospheric polar vortex. Weak polar vortex states tend to reduce regime‐uncertainty, for example, due to more frequent predicted occurrence of Greenland blocking. These regime changes are associated with increased T2m uncertainty over Europe.
Computationally Efficient Emulation of Spheroidal Elastic Deformation Sources Using Machine Learning Models: A Gaussian‐Process‐Based Approach
Authors: Anderson Kyle R. , Gu Mengyang
Published: July 2024

Elastic continuum mechanical models are widely used to compute deformations due to pressure changes in buried cavities, such as magma reservoirs. In general, analytical models are fast but can be inaccurate as they do not correctly satisfy boundary conditions for many geometries, while numerical models are slow and may require specialized expertise and software. To overcome these limitations, we trained supervised machine learning emulators (model surrogates) based on parallel partial Gaussian processes which predict the output of a finite element numerical model with high fidelity but >1,000× greater computational efficiency. The emulators are based on generalized nondimensional forms of governing equations for finite non‐dipping spheroidal cavities in elastic halfspaces. Either cavity volume change or uniform pressure change boundary conditions can be specified, and the models predict both surface displacements and cavity (pore) compressibility. Because of their computational efficiency, using the emulators as numerical model surrogates can greatly accelerate data inversion algorithms such as those employing Bayesian Markov chain Monte Carlo sampling. The emulators also permit a comprehensive evaluation of how displacements and cavity compressibility vary with geometry and material properties, revealing the limitations of analytical models. Our open‐source emulator code can be utilized without finite element software, is suitable for a wide range of cavity geometries and depths, includes an estimate of uncertainties associated with emulation, and can be used to train new emulators for different source geometries.
Integrating Depth Measurements From Gaging Stations With Image Archives for Spectrally Based Remote Sensing of River Bathymetry
Authors: Legleiter Carl J. , Overstreet Brandon T. , Kinzel Paul J.
Published: July 2024

Remote sensing can be an effective tool for mapping river bathymetry, but the need for direct measurements to calibrate image‐derived depth estimates impedes broader application of this approach. One way to circumvent the need for field campaigns dedicated to calibration is to capitalize upon existing data. In this study, we introduce a framework for Bathymetric Mapping using Gage Records and Image Databases (BaMGRID). This workflow involves retrieving depth measurements made during gaging station site visits, downloading archived multispectral images, and then combining these two data sets to establish a relationship between depth and reflectance. We developed a processing chain that involves using application programming interfaces to obtain both depth measurements made during site visits and images centered on the gage and then linking depth to reflectance via an optimal band ratio analysis (OBRA) algorithm modified for small sample sizes. Applying this workflow to selected gages within two river basins indicated that depth retrieval from multispectral satellite images could be highly accurate, but with variable results from one image to the next at a given site. High resolution aerial photography was less conducive to bathymetric mapping in one of the basin considered. Of the four predictors of depth retrieval performance we evaluated (mean and standard deviation of depth, width, and an index of water clarity), only width was consistently significantly correlated with OBRA R2 (p < 0.026). Currently, BaMGRID is best‐suited for site‐by‐site analysis to support practical applications at the reach scale; continuous, basin‐wide mapping of river bathymetry will require additional research.
Enhancing gut microbiota and microbial function with inulin supplementation in children with obesity
Authors: Visuthranukul Chonnikant , Sriswasdi Sira , Tepaamorndech Surapun , Chamni Supakarn , Leelahavanichkul Asada , Joyjinda Yutthana , Aksornkitti Vitavat , Chomtho Sirinuch
Published: July 2024

Background and objectives

Gut dysbiosis that resulted from the alteration between host-microbe interaction might worsen obesity-induced systemic inflammation. Gut microbiota manipulation by supplementation of prebiotic inulin may reverse metabolic abnormalities and improve obesity. This study aimed to determine whether inulin supplementation improved intestinal microbiota and microbial functional pathways in children with obesity.

Methods

Children with obesity whose BMI above median + 2SDs were recruited to a randomized, double-blinded placebo-controlled study. The participants aged 7–15 years were assigned to inulin supplement extracted from Thai Jerusalem artichoke (intervention), maltodextrin (placebo), and dietary fiber advice groups. All participants received similar monthly conventional advice and follow-up for 6 months. Fecal samples were collected for gut microbiome analysis using 16S rRNA sequencing. Phylogenetic Investigation of Communities by Reconstruction of Unobserved States was performed to infer microbial functional pathways.

Results

One hundred and forty-three children with available taxonomic and functional pathway abundance profiles were evaluated. A significant increase in alpha-diversity was observed in the inulin group. Inulin supplementation substantially enhanced Bifidobacterium, Blautia, Megasphaera, and several butyrate-producing bacteria, including Agathobacter, Eubacterium coprostanoligenes, and Subdoligranulum, compared to the other groups. The inulin group showed a significant difference in functional pathways of proteasome and riboflavin metabolism. These changes correlated with clinical and metabolic outcomes exclusively in the inulin group.

Conclusions

Inulin supplementation significantly promoted gut bacterial diversity and improved gut microbiota dysbiosis in children with obesity. The modulation of functional pathways by inulin suggests its potential to establish beneficial interactions between the gut microbiota and host physiology. Inulin supplementation could be a strategic treatment to restore the balance of intestinal microbiota and regulate their functions in childhood obesity.
Electrothermal mineralization of per- and polyfluoroalkyl substances for soil remediation
Authors: Cheng Yi , Deng Bing , Scotland Phelecia , Eddy Lucas , Hassan Arman , Wang Bo , Silva Karla J. , Li Bowen , Wyss Kevin M. , Ucak-Astarlioglu Mine G. , Chen Jinhang , Liu Qiming , Si Tengda , Xu Shichen , Gao Xiaodong , JeBailey Khalil , Jana Debadrita , Torres Mark Albert , Wong Michael S. , Yakobson Boris I. , Griggs Christopher , McCary Matthew A. , Zhao Yufeng , Tour James M.
Published: July 2024

Per- and polyfluoroalkyl substances (PFAS) are persistent and bioaccumulative pollutants that can easily accumulate in soil, posing a threat to environment and human health. Current PFAS degradation processes often suffer from low efficiency, high energy and water consumption, or lack of generality. Here, we develop a rapid electrothermal mineralization (REM) process to remediate PFAS-contaminated soil. With environmentally compatible biochar as the conductive additive, the soil temperature increases to >1000 °C within seconds by current pulse input, converting PFAS to calcium fluoride with inherent calcium compounds in soil. This process is applicable for remediating various PFAS contaminants in soil, with high removal efficiencies ( >99%) and mineralization ratios ( >90%). While retaining soil particle size, composition, water infiltration rate, and cation exchange capacity, REM facilitates an increase of exchangeable nutrient supply and arthropod survival in soil, rendering it superior to the time-consuming calcination approach that severely degrades soil properties. REM is scaled up to remediate soil at two kilograms per batch and promising for large-scale, on-site soil remediation. Life-cycle assessment and techno-economic analysis demonstrate REM as an environmentally friendly and economic process, with a significant reduction of energy consumption, greenhouse gas emission, water consumption, and operation cost, when compared to existing soil remediation practices.
Anomalous friction of supercooled glycerol on mica
Authors: Lizée Mathieu , Coquinot Baptiste , Mariette Guilhem , Siria Alessandro , Bocquet Lydéric
Published: July 2024

Although friction of liquids on solid surfaces is traditionally linked to wettability, recent works have unveiled the role of the solid’s internal excitations on interfacial dissipation. In order to directly evidence such couplings, we take advantage of the considerable variation of the molecular timescales of supercooled glycerol under mild change of temperature to explore how friction depends on the liquid’s molecular dynamics. Using a dedicated tuning-fork AFM, we measure the slippage of glycerol on mica. We report a 100 fold increase of slip length upon cooling, while liquid-solid friction exhibits a linear scaling with molecular relaxation rate at high temperature. This scaling can be explained by a contribution of mica’s phonons which resonate with density fluctuations in the liquid, allowing efficient momentum transfer to mica. These results suggest that engineering phononic spectra of materials could enhance flow performance in nanofluidic channels and industrially relevant membranes.
Reversible metal cluster formation on Nitrogen-doped carbon controlling electrocatalyst particle size with subnanometer accuracy
Authors: Timoshenko Janis , Rettenmaier Clara , Hursán Dorottya , Rüscher Martina , Ortega Eduardo , Herzog Antonia , Wagner Timon , Bergmann Arno , Hejral Uta , Yoon Aram , Martini Andrea , Liberra Eric , Monteiro Mariana Cecilio de Oliveira , Cuenya Beatriz Roldan
Published: July 2024

Copper and nitrogen co-doped carbon catalysts exhibit a remarkable behavior during the electrocatalytic CO2 reduction (CO2RR), namely, the formation of metal nanoparticles from Cu single atoms, and their subsequent reversible redispersion. Here we show that the switchable nature of these species holds the key for the on-demand control over the distribution of CO2RR products, a lack of which has thus far hindered the wide-spread practical adoption of CO2RR. By intermitting pulses of a working cathodic potential with pulses of anodic potential, we were able to achieve a controlled fragmentation of the Cu particles and partial regeneration of single atom sites. By tuning the pulse durations, and by tracking the catalyst’s evolution using operando quick X-ray absorption spectroscopy, the speciation of the catalyst can be steered toward single atom sites, ultrasmall metal clusters or large metal nanoparticles, each exhibiting unique CO2RR functionalities.
Modelling of negative equivalent magnetic reluctance structure and its application in weak-coupling wireless power transmission
Authors: Chen Yuanxi , Niu Shuangxia , Fu Weinong , Lin Hongjian
Published: July 2024

In weak-coupling wireless power transmission, increasing operating frequency, and incorporating metamaterials, resonance structures or ferrite cores have been explored as effective solutions to enhance power efficiency. However, these solutions present significant challenges that need to be addressed. The increased operating frequency boosts ferrite core losses when it exceeds the working frequency range of the material. Existing metamaterial-based solutions present challenges in terms of requiring additional space for slab installation, resulting in increased overall size. In addition, limitations are faced in using Snell’s law for explaining the effects of metamaterial-based solutions outside the transmission path, where the magnetic field can not be reflected or refracted. To address these issues, in this work, the concept of a negative equivalent magnetic reluctance structure is proposed and the metamaterial theory is extended with the proposed magnetic reluctance modelling method. Especially, the negative equivalent magnetic reluctance structure is effectively employed in the weak-coupling wireless power transfer system. The proposed negative equivalent magnetic reluctance structure is verified by the stacked negative equivalent magnetic reluctance structure-based transformer experiments and two-coil mutual inductance experiments. Besides, the transmission gain, power experiments and loss analysis experiments verify the effectiveness of the proposed structure in the weak-coupling wireless power transfer system.
An 8000 years old genome reveals the Neolithic origin of the zoonosis Brucella melitensis
Authors: L’Hôte Louis , Light Ian , Mattiangeli Valeria , Teasdale Matthew D. , Halpin Áine , Gourichon Lionel , Key Felix M. , Daly Kevin G.
Published: July 2024

Brucella melitensis is a major livestock bacterial pathogen and zoonosis, causing disease and infection-related abortions in small ruminants and humans. A considerable burden to animal-based economies today, the presence of Brucella in Neolithic pastoral communities has been hypothesised but we lack direct genomic evidence thus far. We report a 3.45X B. melitensis genome preserved in an ~8000 year old sheep specimen from Menteşe Höyük, Northwest Türkiye, demonstrating that the pathogen had evolved and was circulating in Neolithic livestock. The genome is basal with respect to all known B. melitensis and allows the calibration of the B. melitensis speciation time from the primarily cattle-infecting B. abortus to approximately 9800 years Before Present (BP), coinciding with a period of consolidation and dispersal of livestock economies. We use the basal genome to timestamp evolutionary events in B. melitensis, including pseudogenization events linked to erythritol response, the supposed determinant of the pathogen’s placental tropism in goats and sheep. Our data suggest that the development of herd management and multi-species livestock economies in the 11th–9th millennium BP drove speciation and host adaptation of this zoonotic pathogen.
Copy number losses of oncogenes and gains of tumor suppressor genes generate common driver mutations
Authors: Besedina Elizaveta , Supek Fran
Published: July 2024

Cancer driver genes can undergo positive selection for various types of genetic alterations, including gain-of-function or loss-of-function mutations and copy number alterations (CNA). We investigated the landscape of different types of alterations affecting driver genes in 17,644 cancer exomes and genomes. We find that oncogenes may simultaneously exhibit signatures of positive selection and also negative selection in different gene segments, suggesting a method to identify additional tumor types where an oncogene is a driver or a vulnerability. Next, we characterize the landscape of CNA-dependent selection effects, revealing a general trend of increased positive selection on oncogene mutations not only upon CNA gains but also upon CNA deletions. Similarly, we observe a positive interaction between mutations and CNA gains in tumor suppressor genes. Thus, two-hit events involving point mutations and CNA are universally observed regardless of the type of CNA and may signal new therapeutic opportunities. An analysis with focus on the somatic CNA two-hit events can help identify additional driver genes relevant to a tumor type. By a global inference of point mutation and CNA selection signatures and interactions thereof across genes and tissues, we identify 9 evolutionary archetypes of driver genes, representing different mechanisms of (in)activation by genetic alterations.
Self-powered and speed-adjustable sensor for abyssal ocean current measurements based on triboelectric nanogenerators
Authors: Pan Yuan Chao , Dai Zhuhang , Ma Haoxiang , Zheng Jinrong , Leng Jing , Xie Chao , Yuan Yapeng , Yang Wencai , Yalikun Yaxiaer , Song Xuemei , Han Chang Bao , Shang Chenjing , Yang Yang
Published: July 2024

The monitoring of currents in the abyssal ocean is an essential foundation of deep-sea research. The state-of-the-art current meter has limitations such as the requirement of a power supply for signal transduction, low pressure resistance, and a narrow measurement range. Here, we report a fully integrated, self-powered, highly sensitive deep-sea current measurement system in which the ultra-sensitive triboelectric nanogenerator harvests ocean current energy for the self-powered sensing of tiny current motions down to 0.02 m/s. Through an unconventional magnetic coupling structure, the system withstands immense hydrostatic pressure exceeding 45 MPa. A variable-spacing structure broadens the measuring range to 0.02–6.69 m/s, which is 67% wider than that of commercial alternatives. The system successfully operates at a depth of 4531 m in the South China Sea, demonstrating the record-deep operations of triboelectric nanogenerator-based sensors in deep-sea environments. Our results show promise for sustainable ocean current monitoring with higher spatiotemporal resolution.
International survey on invasive lobular breast cancer identifies priority research questions
Authors: Oesterreich Steffi , Pate Leigh , Lee Adrian V. , Chen Fangyuan , Jankowitz Rachel C. , Mukhtar Rita , Metzger Otto , Sikora Matthew J. , Li Christopher I. , Sotiriou Christos , Shah Osama S. , Koorman Thijs , Ulaner Gary , Reis-Filho Jorge S. , Davidson Nancy M. , Van Baelen Karen , Hutcheson Laurie , Freeney Siobhan , Migyanka Flora , Turner Claire , Derksen Patrick , Bear Todd , Desmedt Christine
Published: July 2024

There is growing awareness of the unique etiology, biology, and clinical presentation of invasive lobular breast cancer (ILC), but additional research is needed to ensure translation of findings into management and treatment guidelines. We conducted a survey with input from breast cancer physicians, laboratory-based researchers, and patients to analyze the current understanding of ILC, and identify consensus research questions. 1774 participants from 66 countries respondents self-identified as clinicians (N = 413), researchers (N = 376), and breast cancer patients and advocates (N = 1120), with some belonging to more than one category. The majority of physicians reported being very/extremely (41%) to moderately (42%) confident in describing the differences between ILC and invasive breast cancer of no special type (NST). Knowledge of histology was seen as important (73%) and as affecting treatment decisions (51%), and most agreed that refining treatment guidelines would be valuable (76%). 85% of clinicians have never powered a clinical trial to allow subset analysis for histological subtypes, but the majority would consider it, and would participate in an ILC clinical trials consortium. The majority of laboratory researchers, reported being and very/extremely (48%) to moderately (29%) confident in describing differences between ILC and NST. They reported that ILCs are inadequately presented in large genomic data sets, and that ILC models are insufficient. The majority have adequate access to tissue or blood from patients with ILC. The majority of patients and advocates (52%) thought that their health care providers did not sufficiently explain the unique features of ILC. They identified improvement of ILC screening/early detection, and identification of better imaging tools as top research priorities. In contrast, both researchers and clinicians identified understanding of endocrine resistance and identifying novel drugs that can be tested in clinical trials as top research priority. In summary, we have gathered information from an international community of physicians, researchers, and patients/advocates that we expect will lay the foundation for a community-informed collaborative research agenda, with the goal of improving management and personalizing treatment for patients with ILC.
Nasal microbiome and the effect of nasal decolonization with a novel povidone-iodine antiseptic solution: a prospective and randomized clinical trial
Authors: Fernández-Rodríguez Diana , Cho Jeongeun , Chisari Emanuele , Citardi Martin J. , Parvizi Javad
Published: July 2024

The aim of this study was to assess the profile of nasal microbiome and evaluate the effect of a specific nasal decolonization solution on the microbiome. We conducted a randomized, placebo-controlled, and parallel-group clinical study of 50 volunteers aged 18 years and older. The subjects were randomly assigned to receive a nasal antiseptic solution, containing povidone-iodine as the main ingredient, (n = 25) or a control solution (n = 25). Nasal swabs were obtained before application (baseline) and at 3 timepoints after application (5 min, 2 h, 24 h). Nasal swabs were subjected to next generation sequencing analysis and cultured in agar plates. At baseline, there were substantial associations between anaerobic species, Corynebacterium spp., Staphylococcus spp., and Dolosigranulum spp. Then, a high bioburden reduction was observed after the application of povidone-iodine (log10 3.68 ± 0.69 at 5 min; log10 3.57 ± 0.94 at 2 h; log10 1.17 ± 1.40 at 24 h), compared to the control. The top species affected by the treatment were Cutibacterium acnes, Staphylococcus, and Corynebacterium species. None of the subjects experienced any adverse effects, nor increases in mucociliary clearance time. Antiseptic solutions applied to the anterior nares can transiently and markedly reduce the bioburden of the nose. The registration number for this clinical trial is NCT05617729.
Automated segmentation of the median nerve in patients with carpal tunnel syndrome
Authors: Moser Florentin , Muller Sébastien , Lie Torgrim , Langø Thomas , Hoff Mari
Published: July 2024

Machine learning and deep learning are novel methods which are revolutionizing medical imaging. In our study we trained an algorithm with a U-Net shaped network to recognize ultrasound images of the median nerve in the complete distal half of the forearm and to measure the cross-sectional area at the inlet of the carpal tunnel. Images of 25 patient hands with carpal tunnel syndrome (CTS) and 26 healthy controls were recorded on a video loop covering 15 cm of the distal forearm and 2355 images were manually segmented. We found an average Dice score of 0.76 between manual and automated segmentation of the median nerve in its complete course, while the measurement of the cross-sectional area at the carpal tunnel inlet resulted in a 10.9% difference between manually and automated measurements. We regard this technology as a suitable device for verifying the diagnosis of CTS.
A study of the effects of early diagenesis on the geotechnical properties of carbonate sediments (North West Shelf, Australia)
Authors: Lebrec Ulysse , Sharma Shambhu , Watson Phil , Riera Rosine , Joer Hackmet , Beemer Ryan , Gaudin Christophe
Published: July 2024

Carbonate sediments are often regarded as problematic in geotechnical engineering due to the high variability of their properties. Understanding and quantifying this variability will become increasingly critical in the years ahead, notably with respect to upcoming developments in offshore renewable energy, for which limited in-situ data are typically available to characterise large areas. Here, six intervals from the North West Shelf of Australia, each composed of similar carbonate grains but accumulated in different environments, are investigated to better understand how the post-depositional cementation, alteration and dissolution of sediments, known as diagenesis, impact their geotechnical properties. Intervals are primarily affected by mineralogy-driven meteoric diagenesis, comprising in-situ dissolution of metastable grains and subsequent precipitation of cement that occurred when the shelf was exposed during lower sea-levels, and by marine diagenesis. In both cases, increased diagenesis results in a higher cement-to-solid ratio and compressive strength. However, while marine diagenesis is associated with a reduction in void ratio, this is not initially observed with mineralogy-driven meteoric diagenesis. Additionally, for a similar cement-to-solid ratio, microcrystalline cement results in higher compressive strength than sparite cement. The data further reveal that the level of meteoric cementation and the compressive strength increase as a function of the duration of exposure and of the regional climate, along with a reduction of the specific gravity related to the replacement of aragonite by calcite. However, increased meteoric diagenesis also leads to the formation of macro-scale heterogeneities such as calcrete layers and karsts that can affect the holistic geotechnical behaviour of such deposits.
Detection and characterization of Deformed Wing Virus (DWV) in apiaries with stationary and migratory management in the province of Entre Ríos, Argentina
Authors: Gonzalez F. N. , Raticelli F. , Ferrufino C. , Fagúndez G. , Rodriguez G. , Miño S. , Dus Santos M. J.
Published: July 2024

In Argentina, migratory activity in search of floral diversity has become a common approach to maximizing honey production. The Entre Ríos province possesses a floral diversity that allows beekeepers to perform migratory or stationary management. Beyond the impact caused by transhumance, migratory colonies in this province start and end the season in monoculture areas. To study the effect of these practices on viral infection, we assayed for the presence, abundance and genetic characterization of the Deformed Wing Virus (DWV) in honey bees from apiaries with both types of management. In migratory apiaries, DWV was detectable in 86.2% of the colonies at the beginning of the season (September 2018), and 66% at the end of the season (March 2019). On the other hand, DWV was detected in 44.11% and 53.12% of stationary samples, at the beginning and the end of the season, respectively. Sequence analysis from migratory and stationary colonies revealed that all samples belonged to DWV-A type. The highest viral loads were detected in migratory samples collected in September. Higher DWV presence and abundance were associated with migratory management and the sampling time. Based on our findings we propose that the benefit of migration to wild flowering areas can be dissipated when the bee colonies end the season with monoculture.
Prognostic value of platelet levels in patients with aneurysmal Subarachnoid Hemorrhage
Authors: Fischer Igor , Lala Ronahi , Donaldson Daniel M. , Schieferdecker Simon , Hofmann Björn B. , Cornelius Jan Frederick , Muhammad Sajjad
Published: July 2024

Pathophysiological processes following aneurysmal subarachnoid hemorrhage (aSAH) include upregulated underlying systemic inflammation, which is reflected by changes in different peripheral blood cells and their sub-populations. As inflammation is a crucial process that contributes to post-aSAH complications and clincal outcome, blood cell numbers and ratios in systemic circulation may predict the outcome and provide rapid and easy to quantify point of care biomarkers for these critically ill patients. To identify blood-derived cellular inflammatory parameters which allow a precise prediction of patient outcome after aSAH. In this single-center retrospective study, 19 whole blood-derived cellular inflammatory markers and clinical and demographic parameters for 101 aSAH patients were recorded within 24 h after aSAH. Clinical outcome was quantified with modified Rankin scale (mRS) on discharge. Proportional odds logistic regression (POLR) was used to model the patient outcome as the function of clinical parameters and inflammatory markers. The results were validated on a separate hold-out dataset (220 patients). The on-admission platelet count, mean platelet volume (MPV) and mean platelet volume to platelet ratio (MPR) were found to be significant and predictive of patient outcome on discharge. Mean platelet volume (MPV) and mean platelet volume to platelet ratio (MPR) predicted clinical outcome and may serve as easy to quantify point of care biomarker. The findings are potentially relevant for the management of aSAH.
PIM1 is a potential therapeutic target for the leukemogenic effects mediated by JAK/STAT pathway mutations in T-ALL/LBL
Authors: Lahera Antonio , Vela-Martín Laura , Fernández-Navarro Pablo , Llamas Pilar , López-Lorenzo José L. , Cornago Javier , Santos Javier , Fernández-Piqueras José , Villa-Morales María
Published: July 2024

Precursor T-cell neoplasms (T-ALL/LBL) are aggressive hematological malignancies that arise from the malignant transformation of immature thymocytes. Despite the JAK/STAT pathway is recurrently altered in these neoplasms, there are not pharmacological inhibitors officially approved for the treatment of T-ALL/LBL patients that present oncogenic JAK/STAT pathway mutations. In the effort to identify potential therapeutic targets for those patients, we followed an alternative approach and focused on their transcriptional profile. We combined the analysis of molecular data from T-ALL/LBL patients with the generation of hematopoietic cellular models to reveal that JAK/STAT pathway mutations are associated with an aberrant transcriptional profile. Specifically, we demonstrate that JAK/STAT pathway mutations induce the overexpression of the PIM1 gene. Moreover, we show that the pan-PIM inhibitor, PIM447, significantly reduces the leukemogenesis, as well as the aberrant activation of c-MYC and mTOR pathways in cells expressing different JAK/STAT pathway mutations, becoming a potential therapeutic opportunity for a relevant subset of T-ALL/LBL patients.
Recent advances in artificial neuromorphic applications based on perovskite composites
Authors: Li Huaxin , Li Qingxiu , Sun Tao , Zhou Ye , Han Su-Ting
Published: July 2024

This review provides a comprehensive overview of the research progress of neuromorphic devices based on composites of perovskites and different materials. The challenges and potential directions for development are also presented.
Renal Regional Oxygen Saturation and Acute Kidney Injury in Neonates with Perinatal Asphyxia
Authors: Agudelo-Pérez Sergio , Troncoso Gloria , Botero-Rosas Daniel , Muñoz Christian , Rodríguez Andrés , Gómez Andrea Valentina , León Jennifer
Published: July 2024

Objective Neonates with moderate-to-severe perinatal asphyxia often develop acute kidney injury (AKI). Additionally, therapeutic hypothermia (TH) can affect renal blood flow. This study aimed to evaluate the association between renal regional oxygen saturation (rSrO2) during TH and AKI in neonates with moderate and severe perinatal asphyxia.

Study Design This retrospective longitudinal study included neonates with moderate-to-severe asphyxia who required TH. The primary outcome was the occurrence of AKI, classified as a rate of decrease in creatinine levels of <33% at 72 hours of TH. rSrO2 was continuously monitored by near-infrared spectroscopy during the hypothermia and rewarming phases. Data analysis involved dividing the average rSrO2 levels into 12-hour periods. We analyzed the association between AKI and rSrO2 levels using univariate and multivariate logistic regression models. Furthermore, we assessed the predictive capacity of rSrO2 for AKI by analyzing the area under the receiver operating characteristic curve.

Results Ninety-one patients were included in the study. On average, patients with AKI exhibit lower rSrO2 levels during TH. Specifically, rSrO2 levels within the first 12 hours and between 25 and 72 hours of TH demonstrated the highest predictive capability for AKI. Multivariate logistic regression analysis revealed that rSrO2 levels within the initial 12 hours (adjusted odds ratio [aOR] = 1.11, 95% confidence interval [CI]: 1.01–1.21) and between 61 and 72 hours (aOR = 0.85, 95% CI: 0.78–0.92) were significantly associated with AKI.

Conclusion An increase in rSrO2 during the first 12 hours of TH and lower rSrO2 levels between 61 and 72 hours of treatment were associated with the development of AKI in asphyxiated neonates undergoing TH.

Key Points
Anti-inflammatory Principles of the Plant Family Amaryllidaceae
Authors: Nair Jerald J. , van Staden Johannes
Published: July 2024

There is considerable interest in the utilisation of plants against inflammation. Over 50 species of the plant family Amaryllidaceae are known for such usage in traditional medicine. This review was undertaken to identify the chemical principles responsible for these anti-inflammatory effects. It describes the findings from in vitro, in vivo and in silico studies, as well as the probes made on the mechanisms of action. The literature search returned over 600 hits, of which around 130 were chosen for their relevance to the text. Over 140 compounds have thus far been screened for anti-inflammatory effects. These were mostly isoquinoline alkaloids but also included other classes of secondary metabolites such as chromones, flavonoids and triterpenoids. In vitro studies were carried out in mononuclear cells such as lymphocytes, monocytes, neutrophils and macrophages, against which no serious side effects were observed. The constituents were also effective
against inflammation induced by physical and chemical stimuli in a variety of murine test subjects. Chief among the compounds were the isoquinoline alkaloids lycorine and narciclasine, which displayed potent effects against pain, swelling, asthma and arthritis, amongst others. From a mechanistic perspective, several of the compounds were shown to mediate in inflammatory pathways, notably via the modulation of both pro-inflammatory (such as NF-κB, TNF-α and IL-1) and anti-inflammatory (such as IL-10 and TGF-β) factors. Useful insights also emerged from active-site docking studies of some of the compounds. The Amaryllidaceae affords a rich and diverse platform for the discovery of potential anti-inflammatory drugs.
Exploring Radiology Postgraduate Students' Engagement with Large Language Models for Educational Purposes: A Study of Knowledge, Attitudes, and Practices
Authors: Sarangi Pradosh Kumar , Panda Braja Behari , P. Sanjay , Pattanayak Debabrata , Panda Swaha , Mondal Himel
Published: July 2024

Background The integration of large language models (LLMs) into medical education has received increasing attention as a potential tool to enhance learning experiences. However, there remains a need to explore radiology postgraduate students' engagement with LLMs and their perceptions of their utility in medical education. Hence, we conducted this study to investigate radiology postgraduate students' knowledge, attitudes, and practices regarding LLMs in medical education.

Materials and Methods A cross-sectional quantitative survey was conducted online on Google Forms. Participants from all over India were recruited via social media platforms and snowball sampling techniques. A previously validated questionnaire was used to assess knowledge, attitude, and practices regarding LLMs. Descriptive statistical analysis was employed to summarize participants' responses.

Results A total of 252 (139 [55.16%] males and 113 [44.84%] females) radiology postgraduate students with a mean age of 28.33 ± 3.32 years participated in the study. The majority of the participants (47.62%) were familiar with LLMs with their potential incorporation with traditional teaching–learning tools (71.82%). They are open to including LLMs as a learning tool (71.03%) and think that it would provide comprehensive medical information (62.7%). Residents take the help of LLMs when they do not get the desired information from books (46.43%) or Internet search engines (59.13%). The overall score of knowledge (3.52 ± 0.58), attitude (3.75 ± 0.51), and practice (3.15 ± 0.57) were statistically significantly different (analysis of variance [ANOVA], p < 0.0001), with the highest score in attitude and lowest in practice. However, no significant differences were found in the scores for knowledge (p = 0.64), attitude (p = 0.99), and practice (p = 0.25) depending on the year of training.

Conclusion Radiology postgraduate students are familiar with LLM and recognize the potential benefits of LLMs in postgraduate radiology education. Although they have a positive attitude toward the use of LLMs, they are concerned about its limitations and use it only in limited situations for educational purposes.
Evolutionary game model and simulation analysis of multi-stakeholder behaviour for promoting Braille labelling on pharmaceutical packaging in China’s legal framework
Authors: Feng Zehua , Liu Xiangdong , Zhao Ying , Huang Zhengzong
Published: July 2024

This study investigates the factors influencing the lack of Braille-embossed labels in Chinese pharmaceutical product packaging. To this end, this study constructs an evolutionary game model of multi-participant behaviour in drug production regulation and conducts simulation based on the perspective of stakeholders in order to study the evolutionary steady state of regulatory authorities, pharmaceutical companies, and visually impaired individuals and the influence of each parameter variable on the choice of strategic behaviour of the participants. The simulation results show that in the legal framework of China, administrative penalties, the production subsidy rate, and the Basic Medical Insurance (BMI) reimbursement rate are the main drivers of the system’s evolution towards a steady state. Reduced costs of drugs with Braille-embossed packaging is a prerequisite for the visually impaired to purchase such drugs, and the key for the whole system to converge to a stable state therefore lies in the BMI reimbursement rate for drugs with Braille-embossed packaging. This paper suggests that the Chinese government should improve the law enforcement mechanism for the regulation of the production of drugs with Braille-embossed packaging; increase the type and intensity of administrative penalties as well as production subsidies, tax incentives, and compliance incentives for pharmaceutical companies; and provide higher BMI reimbursement rates for the visually impaired. The results of the study provide valuable insights to improve accessibility to drugs and build a barrier-free environment for ensuring medication safety in China and other developing countries.
The effect of project approach-based science education program on problem-solving skills of preschool children
Authors: Güley Burcu , Keskinkılıç Ayşegül
Published: July 2024

In this study, the effect of project approach-based science “education program on problem-solving skills” of preschool children attending a kindergarten was investigated. The study was conducted with a quasi-experimental design with pretest and posttest control group at a kindergarten affiliated with the “Ministry of National Education” located in a province in Turkey. The study sample consisted of 70 children (35 in the experimental group, 35 in the control group). The study data were collected through Personal Information Form and Age 4–7 “PSSS”. While the Project Approach-Based Science Education Program (PABSEP) was applied to the children in the experimental group in 28 sessions for three days a week for 10 weeks in addition to the National Education Program, the National Education Program was continued in the control group. As a result of the analyses of the data obtained, significant differences were determined between the “PS” scores of the two groups in favor of the experimental group following the education programs applied (p < 0.05). It was concluded that the PABSEP positively affected the problem-solving skills of the preschool children, and that this effect was permanent (p < 0.05).
Field theoretic description of nonlinear electro-optical responses in centrosymmetric electronic systems
Authors: Paul I
Published: July 2024

Motivated by the recent developments in terahertz spectroscopy using pump-probe setups to study correlated electronic materials, we review the field theoretical formalism to compute finite frequency nonlinear electro-optical responses in centrosymmetric systems starting from basic time dependent perturbation theory. We express the nonlinear current kernel as a sum of several causal response functions. These causal functions cannot be evaluated using perturbative field theory methods, since they are not contour ordered. Consequently, we associate each response function with a corresponding imaginary time ordered current correlation function, since the latter can be factorized using Wick’s theorem. The mapping between the response functions and the correlation functions, suitably analytically continued to real frequencies, is proven exactly. We derive constraints satisfied by the nonlinear current kernel and we prove a generalized f-sum rule for the nonlinear conductivity, all of which are consequences of particle number conservation. The constraints guarantee that the nonlinear static responses are free from spurious divergences. We apply the theory to compute the gauge invariant nonlinear conductivity of a system of noninteracting electrons in the presence of weak disorder. As special cases of this generalized nonlinear response, we discuss its third harmonic and its instantaneous terahertz Kerr signals. The formalism can be used to compute the nonlinear conductivity in symmetry broken phases of electronic systems such as superconductors, density waves and nematic states.
Neuromuscular disease auxiliary diagnosis using a portable magnetomyographic system
Authors: Wei Yutong , Chen Yan , Ye Chaofeng
Published: July 2024

Objective. The measurement of electromyography (EMG) signals with needle electrodes is widely used in clinical settings for diagnosing neuromuscular diseases. Patients experience pain during needle EMG testing. It is significant to develop alternative diagnostic modalities. Approach. This paper proposes a portable magnetomyography (MMG) measurement system for neuromuscular disease auxiliary diagnosis. Firstly, the design and operating principle of the system are introduced. The feasibility of using the system for auxiliary diagnosis of neuromuscular diseases is then studied. The magnetic signals and needle EMG signals of thirty subjects were collected and compared. Main results. It is found that the amplitude of muscle magnetic field signal increases during mild muscle contraction, and the signal magnitudes of the patients are smaller than those of normal subjects. The diseased muscles tested in the experiment can be distinguished from the normal muscles based on the signal amplitude, using a threshold value of 6 pT. The MMG diagnosis results align well with the needle EMG diagnosis. In addition, the MMG measurement indicates that there is a persistence of spontaneous activity in the diseased muscle. Significance. The experimental results demonstrate that it is feasible to auxiliary diagnose neuromuscular diseases using the portable MMG system, which offers the advantages of non-contact and painless measurements. After more in-depth, systematic, and quantitative research, the portable MMG could potentially be used for auxiliary diagnosis of neuromuscular diseases. The clinical trial registration number is ChiCTR2200067116.