bluuebunny/crossref_metadata_2025 huggingface dataset:
Natural infection by Microsporum canis in a capuchin monkey
Authors: Mota Stéphanie Machado , Ferreira Adriano Fernandes , Nery Thiago Lopes , Farias Roberto Citelli de , Mangueira Amanda Figueiredo , Queiroga Felisbina Luísa
Published: May 2017

ABSTRACT: This paper described a case of a capuchin monkey (Sapajus libidinosus) with non-pruritic skin lesions. During the physical examination, multifocal areas of alopecia with crusts, erythema and scaling compatible with dermatophytosis were reported on the right fore and hind limbs and on tail. Fungal culture findings revealed a diagnosis of dermatophytosis due to Microsporum canis. The animal was successfully treated with itraconazole. This is the first report of a dermatophytosis case in S. libidinosus and the first description of an effective treatment in this species.
Urolithiasis with uroperitoneum and hydronephrosis in grazing cattlein Southern Brazil
Authors: Santos Bianca Lemos dos , Pereira Clairton Marcolongo , Coelho Ana Carolina Barreto , Silva Pablo Estima , Oliveira Plínio Aguiar de , Stigger Adriana Lücke , Schild Ana Lucia
Published: May 2017

ABSTRACT: The purpose of this paper was to describe obstructive urolithiasis with uroperitoneum and hydronephrosis in range cattle in southern Rio Grande do Sul. The disease was observed in castrated male cattle, aged between 18 months and 3 years in a herd of 200 steers that were in a ryegrass pasture during the winter and a native pasture during the summer. Different mineral salts were used as a supplement for the animals during the two seasons of the year. Cattle presented a progressive abdominal distention, depression and dehydration ranging from 10 days to one month in duration. One animal was necropsied, and approximately 50 liters of urine (uroperitoneum) in the abdominal cavity were observed. The bladder had a small rupture and was adhered to the pelvic cavity. The right kidney was enlarged with hydronephrosis. Uroliths of more than 1cm in diameter were housed in the penile urethra. In this study, the disease occurred probably because of mineral salt supplementation, resulting in an imbalance of calcium and phosphorus intake.
Comparative analysis of death by suicide in Brazil and in the United States: descriptive, cross-sectional time series study
Authors: Abuabara Alexander , Abuabara Allan , Tonchuk Carin Albino Luçolli
Published: May 2017

ABSTRACT CONTEXT AND OBJECTIVE: The World Health Organization recognizes suicide as a public health priority. Increased knowledge of suicide risk factors is needed in order to be able to adopt effective prevention strategies. The aim of this study was to analyze and compare the association between the Gini coefficient (which is used to measure inequality) and suicide death rates over a 14-year period (2000-2013) in Brazil and in the United States (US). The hypothesis put forward was that reduction of income inequality is accompanied by reduction of suicide rates. DESIGN AND SETTING: Descriptive cross-sectional time-series study in Brazil and in the US. METHODS: Population, death and suicide death data were extracted from the DATASUS database in Brazil and from the National Center for Health Statistics in the US. Gini coefficient data were obtained from the World Development Indicators. Time series analysis was performed on Brazilian and American official data regarding the number of deaths caused by suicide between 2000 and 2013 and the Gini coefficients of the two countries. The suicide trends were examined and compared. RESULTS: Brazil and the US present converging Gini coefficients, mainly due to reduction of inequality in Brazil over the last decade. However, suicide rates are not converging as hypothesized, but are in fact rising in both countries. CONCLUSION: The hypothesis that reduction of income inequality is accompanied by reduction of suicide rates was not verified.
Terapia fibrinolítica sistêmica no tromboembolismo pulmonar
Authors: Ceresetto José Manuel , Marques Marcos Arêas
Published: May 2017

Resumo O tromboembolismo pulmonar permanece como um grande desafio terapêutico para os médicos especialistas, pois, apesar de todo investimento e desenvolvimento em seu diagnóstico, profilaxia e tratamento, essa condição continua sendo a principal causa de morte evitável em ambiente hospitalar. Ainda restam muitas dúvidas em relação a qual perfil de paciente vai se beneficiar de fato da terapia fibrinolítica sistêmica, sem ficar exposto a um grande risco de sangramento. A estratificação de risco e a avaliação do prognóstico do evento, através de escores clínicos de insuficiência ventricular direita, marcadores de dilatação e disfunção do ventrículo direito e avaliação da massa trombótica, associados ou de forma isolada, são ferramentas que podem auxiliar na identificação do paciente que irá se beneficiar dessa terapia. Os únicos consensos em relação à terapia fibrinolítica no tratamento do tromboembolismo pulmonar são: não deve ser indicada de forma rotineira; nenhum dos escores ou marcadores, isoladamente, devem justificar seu uso; e os pacientes com instabilidade hemodinâmica são os mais beneficiados. Além disto, deve-se avaliar cada caso em relação ao risco de sangramento, especialmente no sistema nervoso central.
Identificação pela ultrassonografia vascular dos diâmetros das veias safenas magnas sem refluxo em mulheres
Authors: Engelhorn Carlos Alberto , Engelhorn Ana Luiza , Ritter Camila , Lima Gabriel Faria Isfer de , Lopes João Gabriel Peixoto , Cabrini Letícia Gaertner
Published: May 2017

Resumo Contexto A ultrassonografia vascular (UV) é o exame de escolha para estudar o sistema venoso superficial dos membros inferiores e mensurar o diâmetro das veias safenas, podendo ser utilizada como parâmetro para o planejamento cirúrgico. Objetivos Identificar pela UV os diâmetros de veias safenas magnas sem refluxo em mulheres e sua relação com a idade, altura, Classificação Clínica, Etiologia, Anatomia e Fisiopatologia (CEAP) e índice de massa corporal (IMC). Métodos Estudo transversal em mulheres com sintomas de IVC primária (C0, 1 ou 2), sem cirurgia prévia de varizes e sem refluxo detectado pela UV, nas quais foram mensurados os diâmetros da veia safena magna (VSM) na crossa, coxa e perna, que foram comparados com a idade, altura, classe clínica CEAP e IMC. Resultados Foram avaliadas 353 mulheres, das quais 146 foram incluídas no estudo sendo 88 avaliadas unilateralmente e 58 bilateralmente. Os diâmetros encontrados para a VSM sem refluxo foram de aproximadamente 6,5 mm na crossa, 4,0 mm na coxa proximal, 3.0 mm na coxa médio-distal e joelho e 2,5 mm na perna. Em todos os segmentos mensurados houve diferença estatisticamente significativa (p < 0,05) na correlação dos diâmetros com IMC. Não houve diferença estatística na correlação da medida dos diâmetros com classe CEAP, altura e idade das pacientes. Conclusões Observou-se que os diâmetros de veias safenas magnas sem refluxo independem da classe clínica CEAP 0 ou 1 e 2; da idade e da altura das pacientes. Entretanto, os diâmetros da VSM se relacionam significativamente com o IMC das pacientes.
Avaliação in vitro da adsorção de aflatoxina B1 por produtos comerciais utilizados na alimentação animal
Authors: Pinheiro Raizza Eveline Escórcio , Pereyra Carina Maricel , Neves Josyanne Araújo , Calvet Rodrigo Maciel , Santos Julliet Teixeira de Oliveira , Lima Cristiane Evangelista , Alves Verbena Carvalho , Pereira Maria Marlucia Gomes , Muratori Maria Christina Sanches
Published: May 2017

RESUMO: Objetivou-se avaliar a capacidade de adsorção in vitro de aflatoxina B1 (AFB1) por produtos comerciais utilizados na alimentação animal. Muitas pesquisas estão sendo realizadas para a descontaminação de AFB1 em alimentos. Os produtos comerciais utilizados frequentemente na alimentação de peixes, disponíveis na forma de probióticos, são formados por cepas de bactérias e leveduras utilizadas na maioria dos ensaios de adsorção de micotoxinas. Foram utilizados três produtos comerciais: A, composto por Bacillus subtilis, Bifidobacterium bifidum, Enterococcus faecium e Lactobacillus acidophilus; B, por leveduras secas de Saccharomyces cerevisiae provenientes de cervejaria; e C, por Bacillus subtilis, Bacillus licheniformis e Bacillus pumilus. Cinco suspensões da dose máxima recomendada pelo fabricante de cada produto (0; 25; 50; 75 e 100%) foram testadas contra AFB1 (1000 ng.mL-1) em microtubos para determinação da capacidade de adsorção. Para simular o pH do estômago e do intestino de tilápias do Nilo (Oreochromis niloticus) foram formuladas soluções tampão fosfato salino (PBS), com pH 1,5 e 7,5; respectivamente. Os microtubos foram introduzidos em uma centrífuga com agitação mecânica, a 37ºC por 1 h e depois centrifugados por 10 min a 14.000 rpm; os sobrenadantes foram quantificados por cromatografia líquida de alta eficiência. Os produtos comerciais, nas concentrações máximas, foram capazes de adsorver AFB1 em quantidades de 45,01 a 129,59; 123,90 a 215,59 e 209,98 a 370,73 ng.mL-1, respectivamente. Concluiu-se que todos os produtos comerciais analisados adsorvem AFB1 em condições simuladas de pH gastrointestinal e são candidatos potenciais para adsorção de AFB1 para futuros ensaios in vivo.
Conhecimento sobre síndrome da imunodeficiência humana de idosos de uma unidade de atenção ao idoso
Authors: Nardelli Giovanna Gaudenci , Malaquias Bruna Stephanie Sousa , Gaudenci Eliana Maria , Ledic Carolina Silva , Azevedo Nayara Freitas , Martins Vitória Eugênia , Santos Álvaro da Silva
Published: May 2017

RESUMO Objetivo Análise do conhecimento de idosos acerca da síndrome e do vírus da imunodeficiência humana. Métodos Estudo descritivo, transversal e quantitativo envolvendo 457 idosos da Unidade de Atenção ao Idoso de Uberaba, Minas Gerais, durante 3 meses. Foram aplicados os instrumentos Mini Exame do Estado Mental e o questionário sobre o vírus da imunodeficiência humana para terceira idade e, para a análise, foram usadas medidas de frequência. Resultados A maioria dos participantes eram mulheres (74%), entre 60 a 69 anos (51%). O maior índice de acertos obteve a transmissão por agulhas 96,2% e o menor (45,3%), a transmissão pela picada de mosquito e se a pessoa com o vírus da imunodeficiência humana sempre apresenta sintomas (49,6%). 88,2% deles relataram nunca usar camisinha. Conclusões O nível geral de conhecimento pode ser considerado bom, respondendo ao nosso objetivo. No entanto, foram identificadas lacunas decorrentes da falta de campanhas voltadas exclusivamente para tal público, bem como na conscientização de profissionais.
Mecanismos jurídicos e econômicos para a transferência de tecnologia: um estudo de caso
Authors: Ribeiro Marcia Carla Pereira , Rocha Jr Weimar Freire da , Czelusniak Vivian Amaro
Published: May 2017

Resumo O trabalho analisa mecanismos para a eficiência dos negócios empresariais de transferência de tecnologia. Utiliza a ferramenta da análise econômica do direito em razão de sua adequação para estudos relacionados às modalidades negociais que se protraem no tempo, nos quais a confiança entre as partes torna-se fundamental para a manutenção das relações. O método de procedimento utilizado neste ensaio foi o monográfico, a técnica de pesquisa foi a bibliográfica e o estudo de caso, de transferência de tecnologia em biogás. Como resultados, vislumbrou-se que a cooperação é um instrumento para que os negócios empresariais e os contratos empresariais de transferência de tecnologia sejam mais efetivos, na medida em que pode diminuir a probabilidade de demandas judiciais referentes a estes contratos, bem como é instrumento de estabilização, promovendo a manutenção dos negócios por um maior período de tempo.
ANTI-TTG AMONG CHILDREN WITH CHRONIC FUNCTIONAL CONSTIPATION UNRESPONSIVE TO 6 WEEKS OF TREATMENT OF CONSTIPATION
Authors: SADJADEI Nooshin , HOSSEINMARDY Samaneh , HAKIMZADEH Mehran , ZIAEI KAJBAF Tahereh , JAVAHERIZADEH Hazhir
Published: May 2017

ABSTRACT BACKGROUND Celiac disease is a glutten induced enteropathy. Some authors recommended screening celiac in children with constipation. There are studies to evaluate celiac disease in children with constipation. But most of them included children regardless to treatment failure. OBJECTIVE The aim of this study was to evaluate frequency of elevated anti TTG in children with constipation after failure to improve during 6 week of appropriate treatment of constipation. METHODS In this cross sectional study, 550 children with prolonged constipation were included. Place of study was Pediatric Gastroenterology clinic of Abuzar children’s hospital. Prolonged constipation was defined as a constipation which failed to resolved after 6 weeks of appropriate treatment. Constipation was defined according to ROME III criteria. After parental agreement, 5 mL of blood was obtained. Serum anti TTG level was measure using ELISA method by Orientec kit. Anti TTG>10 was considered positive if IgA was normal. SPSS version 16.0 (Chicago, IL, USA) was used for data analysis. Chi square, t-test, and Mann Whitney test used for data analysis. RESULTS In this study 550 children (m=277, f=273) were included. Mean age of the cases was 6.8±2.9 year. Anti TTG antibody level was 5.8±2.8 unit/mL. Of these case, 42 (7.6%) had positive anti-TTG antibody. Celiac disease was confirmed in 40 cases after histopathology examination. CONCLUSION Anti-TTG was positive in 7.6% children with chronic constipation who failed to respond after 6 week of treatment. Another multicenter study with longer follow up period is recommended.
Planejamento urbano, arquitetura e urbanismo: a serviços de uma outra geografia? Brasilmar Ferreira Nunes (em memória)
Authors: Nunes Christiane Girard Ferreira , Lacerda Norma
Published: May 2017

Resumo O presente artigo trata de um escrito inacabado e inédito de autoria de Brasilmar Ferreira Nunes, falecido em abril de 2016. O objetivo de suas reflexões é mostrar como a nova e íntima associação entre planejamento urbano, urbanismo e arquitetura vem se destacando nas metrópoles, notadamente naquelas do Oriente e Oriente Médio, regiões do globo onde, por razões estratégicas e econômicas, o capitalismo vem se consolidando de forma hegemônica. Ao reconhecer a importante contribuição analítica de Brasilmar Nunes, Christiane Girard introduz o texto, salientando traços da trajetória deste sociólogo que tanto influiu na sua produção acadêmica. Norma Lacerda, por sua vez, finaliza chamando a atenção sobre o ineditismo do artigo e comentando sobre a diversidade de temas por ele abordados.
Tuberculosis recurrence in a priority city in the state of São Paulo, Brazil
Authors: Vieira Amadeu Antonio , Leite Danila Torres , Adreoni Solange
Published: May 2017

ABSTRACT Objective: To describe cases of tuberculosis recurrence (TBR), stratified by temporal classification (early or late TBR), and to identify possible predictors of such recurrence. Methods: This was an analytical retrospective observational epidemiological study involving a cohort of 963 new cases of pulmonary tuberculosis, reported and treated via the Tuberculosis Control Program in the city of Carapicuíba, Brazil. The study period was from 2000 to 2010. All of the pulmonary tuberculosis patients who successfully completed the treatment (with or without confirmation of cure) were selected and followed until December 31, 2012. Results: Of the 963 cases, TBR occurred in 47 (4.88%). The mean time between the first and second tuberculosis episodes was 36.12 months. Of the 47 TBR cases, 16 (34.04%) occurred within the first 18 months after the completion of the initial treatment (early TBR) and 31 (65.96%) occurred thereafter (late TBR). There were statistically significant differences between the early and late TBR groups only regarding level of education (≤ 3 vs. > 3 years of schooling; p < 0.004) and weight gain at completion of the initial treatment (1.78 kg vs. 5.31 kg; p < 0.045)-not regarding any of the other variables studied. Conclusions: A low level of education might translate to poor treatment adherence, which impedes the killing of bacilli and facilitates their survival in a latent state, making it appear as if the treatment was effective. Minimal or no weight gain at completion of the initial treatment might be a reliable biomarker to be used by health care facilities that provide tuberculosis treatment.
Sweat test and cystic fibrosis: overview of test performance at public and private centers in the state of São Paulo, Brazil
Authors: Servidoni Maria Fátima , Gomez Carla Cristina Souza , Marson Fernando Augusto Lima , Toro Adyléia Aparecida Dalbo Contrera , Ribeiro Maria Ângela Gonçalves de Oliveira , Ribeiro José Dirceu , Ribeiro Antônio Fernando
Published: May 2017

ABSTRACT Objective: The sweat test (ST) measures chloride levels in sweat and is considered the gold standard for the diagnosis of cystic fibrosis (CF). However, the reliability of a ST depends on their being performed by experienced technicians and in accordance with strict guidelines. Our aim was to evaluate how sweat stimulation, sweat collection, and chloride measurement are performed at 14 centers (9 public centers and 5 private centers) that routinely perform STs in the state of São Paulo, which has the highest frequency of CF in Brazil. Methods: This was a cross-sectional cohort study, using a standardized questionnaire administered in loco to the staff responsible for conducting STs. Results: No uniformity regarding the procedures was found among the centers. Most centers were noncompliant with the international guidelines, especially regarding the collection of sweat (the samples were insufficient in 10-50% of the subjects tested); availability of stimulation equipment (which was limited at 2 centers); modernity and certification of stimulation equipment (most of the equipment having been used for 3-23 years); and written protocols (which were lacking at 12 centers). Knowledge of ST guidelines was evaluated at only 1 center. Conclusions: Our results show that STs largely deviate from internationally accepted guidelines at the participating centers. Therefore, there is an urgent need for standardization of STs, training of qualified personnel, and acquisition/certification of suitable equipment. These are essential conditions for a reliable diagnosis of CF, especially with the increasing demand due to newborn screening nationwide, and for the assessment of a possible clinical benefit from the use of modulator drugs.
Tracheobronchopathia osteochondroplastica
Authors: Silveira Mara Graziele Maciel , Castellano Maria Vera Cruz de Oliveira , Fuzi Clarice Emiko , Coletta Ester Nei Aparecida Martins , Spinosa Guilherme Nogueira
Published: May 2017

ABSTRACT Tracheobronchopathia osteochondroplastica is a rare benign disease, of unknown cause, characterized by numerous sessile, cartilaginous, or bony submucosal nodules distributed throughout the anterolateral walls, projecting into the laryngotracheobronchial lumen. In general, tracheobronchopathia osteochondroplastica is diagnosed incidentally during bronchoscopy or autopsy and is not associated with a specific disease. We report the case of a male patient who was diagnosed with tracheobronchopathia osteochondroplastica via bronchoscopy and biopsy.
Health Care Resource Utilization and Associated Costs Among Metastatic Cutaneous Melanoma Patients Treated with Ipilimumab (INTUITION Study)
Authors: McArthur Grant A. , Mohr Peter , Ascierto Paolo Antonio , Arance Ana , Banos Hernaez Ana , Kaskel Peter , Weichenthal Michael , Shinde Reshma , Stevinson Kendall
Published: May 2017

Background

There are limited real-world data on health care resource utilization (HCRU) among advanced melanoma patients. The objective of this study was to describe HCRU and health care costs associated with the management of advanced melanoma patients receiving ipilimumab.

Methods

This retrospective multinational, observational study included advanced melanoma patients from Australia, Germany, Italy, and Spain who had received at least 1 dose of ipilimumab. Data extracted from medical charts included inpatient admissions, outpatient visits, surgical procedures, laboratory investigations, radiation therapy, imaging studies, and concomitant medications. Cost estimates were based on unit costs from country-specific standard reimbursement sources. Subgroup analyses were performed for BRAF mutation status and ipilimumab refractory patients, who had disease progression within 24 weeks of their last dose of ipilimumab.

Results

Mean age of 362 enrolled patients was 60.6 years (standard deviation [SD] 14.4). During a median follow-up period of 30.2 weeks, 57% of patients were admitted to hospital and 16% underwent surgery. Health care resource utilization rates varied substantially across countries and were highest in Germany. Concomitant medications to treat adverse events were commonly used. Subgroup analyses showed higher utilization rates among ipilimumab refractory and BRAF mutant patients. Mean weekly total costs associated with HCRU were lower in the pre-progression period (€107; 95% confidence interval (CI): 79–145) than in the post-progression period (€216; 95% CI: 180–259).

Conclusion

Health care resource utilization pattern and associated costs among patients treated with ipilimumab varied greatly among countries and between pre- and post-progression periods. There is a high economic burden associated with ipilimumab refractory melanoma.
Targeting BRAF-Mutant Non-Small Cell Lung Cancer: From Molecular Profiling to Rationally Designed Therapy
Authors: Baik Christina S. , Myall Nathaniel J. , Wakelee Heather A.
Published: May 2017

Non-small cell lung cancer (NSCLC) remains the leading cause of cancer-related deaths globally. However, the identification of oncogenic driver alterations involved in the initiation and maintenance of NSCLC, such as epidermal growth factor receptor mutations and anaplastic lymphoma kinase translocation, has led to the development of novel therapies that directly target mutant proteins and associated signaling pathways, resulting in improved clinical outcomes. As sequencing techniques have improved, the molecular heterogeneity of NSCLC has become apparent, leading to the identification of a number of potentially actionable oncogenic driver mutations. Of these, one of the most promising therapeutic targets is B-Raf proto-oncogene, serine/threonine kinase (BRAF). Mutations in BRAF, observed in 2%–4% of NSCLCs, typically lead to constitutive activation of the protein and, as a consequence, lead to activation of the mitogen-activated protein kinase signaling pathway. Direct inhibition of mutant BRAF and/or the downstream mitogen-activated protein kinase kinase (MEK) has led to prolonged survival in patients with BRAF-mutant metastatic melanoma. This comprehensive review will discuss the clinical characteristics and prognostic implications of BRAF-mutant NSCLC, the clinical development of BRAF and MEK inhibitors from melanoma to NSCLC, and practical considerations for clinicians involving BRAF mutation screening and the choice of targeted therapy.
Male Breast Cancer as a Second Primary Cancer: Increased Risk Following Lymphoma
Authors: Farr Deborah E. , Thomas Alexandra , Khan Seema Ahsan , Schroeder Mary C.
Published: May 2017

Background

Male breast cancer (MBC) as a second primary cancer (SPC) has a known association with prior MBC. However, its association with non-breast index malignancies, relative to population risk, has not been previously reported.

Materials and Methods

Using Surveillance, Epidemiology, and End Results program (9 catchment area) data, we identified MBCs diagnosed from 1973–2012 as their SPC. Information regarding the index malignancy was also obtained. Standardized incidence ratios (SIR) of MBC as SPC were estimated, along with incidence rates and trends. Kaplan-Meier curves were used to estimate survival.

Results

Over a 38-year period, 464 MBCs were identified as SPC. The most common index malignancies were breast (SIR 30.86, 95% confidence interval [CI] 21.50–42.92, p < .001), lymphoma (SIR 1.58, 95% CI 1.08–2.22, p = .014), melanoma (SIR 1.26, 95% CI 0.80–1.89), urinary (SIR 1.05, 95% CI 0.74–1.43), colorectal (SIR 0.94, 95% CI 0.69–1.24), and prostate (SIR 0.93 95% CI 0.81–1.07). Apart from the known association with prior breast cancer, the only significant association was with lymphoma as an index cancer, although not significant with a Bonferroni correction. From 1975–2012, incidence of breast cancer as a first cancer increased at an annual percentage change of 1.3% while breast cancer as a SPC increased at 4.7% (both p values < .001).

Conclusion

Male breast cancer as a SPC has increased markedly over 4 decades. Men with a history of lymphoma may experience higher-than-expected rates of breast SPC. These observations warrant further research, and suggest possible etiologic connections with disease biology, prior therapy, or genetics.
Phase II Study of Modified Carboplatin Plus Weekly Nab-Paclitaxel in Elderly Patients with Non-Small Cell Lung Cancer: North Japan Lung Cancer Study Group Trial 1301
Authors: Miyauchi Eisaku , Inoue Akira , Usui Kazuhiro , Sugawara Shunichi , Maemondo Makoto , Saito Heisuke , Fujita Yuka , Kato Terufumi , Suzuki Toshiro , Harada Toshiyuki , Watanabe Hiroshi , Nakagawa Taku , Ichinose Masakazu
Published: May 2017

Lessons Learned

Weekly nanoparticle albumin-bound-paclitaxel (75 mg/m2) in combination with carboplatin (area under the curve 6 mg/mL/min) in elderly patients with previously untreated, advanced non-small cell lung cancer showed favorable efficacy, was well tolerated, and showed less neuropathic toxicity. This modified regimen offers potential for the treatment of elderly patients.

Background

The CA031 trial suggested weekly nanoparticle albumin-bound-paclitaxel (nab-PTX) was superior in efficacy to paclitaxel (PTX) once every 3 weeks when combined with carboplatin (CBDCA) for advanced non-small cell lung cancer (NSCLC) patients; a subgroup analysis of elderly patients looked promising. In a multicenter phase II trial, we prospectively evaluated the efficacy and tolerability of modified CBDCA plus weekly nab-PTX for elderly patients with untreated advanced NSCLC.

Methods

Eligible patients received CBDCA (area under the curve [AUC] 6 mg/mL/min) on day 1 and nab-PTX (75 mg/m2) on days 1, 8, and 15 every 4 weeks. The primary endpoint was an overall response rate (ORR), and secondary endpoints were progression-free survival (PFS), overall survival (OS), and toxicity.

Results

Of 32 patients (median age of 78 years), 84% were male, 56% had stage IV NSCLC, and 56% had squamous cell carcinoma. ORR and disease control rates were 50% (95% confidence interval (CI): 33–67) and 94% (95% CI: 85–100), respectively. Median PFS and OS were 6.4 months (95% CI: 4.8–8.0) and 17.5 months (95% CI: 11.9–23.1), respectively. Grade ≥3 toxicities were neutropenia (47%), leukopenia (38%), anemia (34%), thrombocytopenia (25%), and anorexia (9%). Febrile neutropenia and treatment-related deaths were not observed.

Conclusion

Modified CBDCA plus weekly nab-PTX demonstrated significant efficacy and acceptable toxicities in elderly patients with advanced NSCLC.
The Phenotypic Spectrum of Nephropathies Associated with Mutations in Diacylglycerol Kinase ε
Authors: Azukaitis Karolis , Simkova Eva , Majid Mohammad Abdul , Galiano Matthias , Benz Kerstin , Amann Kerstin , Bockmeyer Clemens , Gajjar Radha , Meyers Kevin E. , Cheong Hae Il , Lange-Sperandio Bärbel , Jungraithmayr Therese , Frémeaux-Bacchi Véronique , Bergmann Carsten , Bereczki Csaba , Miklaszewska Monika , Csuka Dorottya , Prohászka Zoltán , Gipson Patrick , Sampson Matthew G. , Lemaire Mathieu , Schaefer Franz
Published: May 2017

The recent discovery of mutations in the gene encoding diacylglycerol kinase ε (DGKE) identified a novel pathophysiologic mechanism leading to HUS and/or MPGN. We report ten new patients from eight unrelated kindreds with DGKE nephropathy. We combined these cases with all previously published cases to characterize the phenotypic spectrum and outcomes of this new disease entity. Most patients presented with HUS accompanied by proteinuria, whereas a subset of patients exhibited clinical and histologic patterns of MPGN without TMA. We also report the first two patients with clinical and histologic HUS/MPGN overlap. DGKE-HUS typically manifested in the first year of life but was not exclusively limited to infancy, and viral triggers frequently preceded HUS episodes. We observed signs of complement activation in some patients with DGKE-HUS, but the role of complement activation remains unclear. Most patients developed a slowly progressive proteinuric nephropathy: 80% of patients did not have ESRD within 10 years of diagnosis. Many patients experienced HUS remission without specific treatment, and a few patients experienced HUS recurrence despite complete suppression of the complement pathway. Five patients received renal allografts, with no post-transplant recurrence reported. In conclusion, we did not observe a clear genotype-phenotype correlation in patients with DGKE nephropathy, suggesting additional factors mediating phenotypic heterogeneity. Furthermore, the benefits of anti-complement therapy are questionable but renal transplant may be a feasible option in the treatment of patients with this condition.
Indigenous knowledge/s of survival: implications for lifelong learning among the Basotho herding fraternity
Authors: Pitikoe Selloane , Morojele Pholoho
Published: May 2017

This article foregrounds Basotho male herders' interaction with their environment as a productive platform for informal learning activities poised to address the herders' immediate and context-specific needs. Indeed, understanding how the herders interact and learn through their daily engagements with their environments has a potential to provide substantive baseline insights that could inform Lesotho's nonformal education providers and policy-making forums. Drawing on indigenous knowledge theory, the article explicates the sociocultural perspective of indigenous knowledge with emphasis on how it is acquired and applied by male Basotho herders in order to improve their lives and address their daily herding challenges. The study adopted a qualitative research methodology with a sample of 30 snowball-selected Basotho male herders using interviews, transect walk, and photo voice as its methods of data collection. The data were analysed using the pattern coding method. The findings revealed two main forms of indigenous knowledge that the herders acquired through the herding practice namely, indigenous knowledge as local science and indigenous knowledge as local practice. The study recommends more scientific research that documents Lesotho's specific indigenous knowledge-to develop a holistic nonformal education curriculum and to nurture the rare indigenous knowledge skills of the Basotho male herders.
PRODUÇÃO E DECOMPOSIÇÃO DE BIOMASSA DE PLANTAS DE COBERTURA CULTIVADAS NA PRIMAVERA
Authors: Assis Renato Lara de , Boer Carlo Adriano , Pacheco Leandro Pereira , Braga Pereira Braz Antonio Joaquim , De Pinho Costa Kátia Aparecida , Rodrigues Torres José Luiz
Published: May 2017

O cultivo de gramíneas para fins de produção de palhada tem crescido principalmente em regiões de clima tropical, proporcionando elevada produção de biomassa e manutenção da cobertura do solo. O presente estudo teve por objetivo avaliar a produção e decomposição de biomassa de plantas de cobertura do solo, cultivadas na primavera antecedendo ao cultivo do milho. O experimento foi instalado no Centro Tecnológico da Comigo no município de Rio Verde (GO) em um Latossolo Vermelho distrófico textura argilosa. Foram utilizadas cultivares de milheto (ADR300, ADR500 e ADR7010), capim pé-de-galinha (Eleusine coracana), cober crop® e uma testemunha com vegetação espontânea. O delineamento experimental foi o de blocos ao acaso com quatro repetições. As maiores produções em biomassa, aos 50 dias após a semeadura, foram observadas para o cober crop® e milheto ADR 500, com valores superiores à 15.000 kg ha-1. Quanto à relação C/N, o capim pé-de-galinha e a testemunha apresentaram menores valores, diferindo dos milhetos ADR500 e ADR7010. Os milhetos e o cober crop® foram eficientes em manter o solo coberto em razão da maior quantidade de biomassa remanescente na fase inicial de implantação da cultura do milho, seguido pelo capim pé-de-galinha co.m menor decomposição da palhada.
THE DEVELOPMENT OF MATHEMATICAL SPEECH OF FUTURE TEACHERS IN THE STUDY COURSE METHODOLOGY OF MATHEMATICS
Authors: Sergeeva Larisa , Ledovaya Alina
Published: May 2017

The article is devoted to setting forth of the urgent problem of the cultural development of mathematical speech of future teachers. The article shows the study of mathematical concepts by students taking into account specialized language of the mathematics as one of the aspects of this problem. The proposed method of development of mathematical speech is based on the constructed hierarchy of mathematical concepts consideration the specifics of mathematical objects’ nature and characteristics of the used mathematical language. The conducted research allowed to establish the influence of the created active studying for developing students' methodological speech, cognitive motives, interest in future professional activity.
FUTURE TECHNOLOGY TEACHERS’ PROFESSIONAL TRAINING IN TERMS OF UKRAINE'S INTEGRATION INTO THE EUROPEAN EDUCATIONAL SPACE
Authors: Kurok Vira , Voitelieva Galyna
Published: May 2017

The peculiarities and tendencies of educational space development in countries of Europe were characterized in the process of studying the European experience of future specialists’ professional training. The current state of future Technology teachers’ professional training in Ukraine was analyzed. The congruence of the Ukrainian educational system to the requirements of the European educational space was established. The ways of improving the professional staff training for the purpose of European integration are defined.
PROBLEMS OF PSYCHO DIDACTICS IN UNIVERSITY AND POSSIBLE WAYS OF THEIR SOLUTION
Authors: Moskalenko Olga Valentinovna
Published: May 2017

This article is devoted to the study of two main problems – whom and how to teach in a university. Theoretical analysis substantiated the thesis that the inefficiency of teaching students is connected directly with the lack of teachers’ knowledge about psychological peculiarities of modern student community. Accordingly, the research shows the contrariety between this age and forms of its appearance as one of students’ specifics. One of main consequences of those problems is the genesis and development of student infantilism, which has such essential characteristics: ambivalence, motivational stimulating force, behavioral form, protracted nature of infantilism and its extending, possibility of its overcoming and correction. The particular research set effective algorithm and the program of psychological correction of student’s infantilism while obtaining higher education. The second problem is devoted to the necessity of using teaching psycho didactical methods to create conditions for personal cognitive development. Theoretical analysis and empiric research identified the method system to develop cognitive process: for memory – enlarging didactic units as factors for systematizing learning materials and students’ knowledge; attention – improving individual controlled work of students; information representation – text manipulation and multimedia didactics; feelings – emotional and willful control, decision taking ability logic development; imagination – didactical games.
EXPLORING 35-44 YEAR OLD MEN’S HEALTH BEHAVIOUR: A QUALITATIVE PERSPECTIVE
Authors: Silkane Vineta , Austers Ivars
Published: May 2017

Upon reaching 35-44 year of age, men experience their first health problems, often because of an unhealthy way of life e.g., smoking, physical inactivity, unhealthy nutrition habits, etc. In comparison with other age groups, these men rarely look for medical help, thus, opening themselves up to a number of potentially negative consequences e.g. health risks in future. This study explores the health behaviour of 35-44 year old men by conducting semi-structured in-depth interviews with 48 participants. The data are further analysed using inductive thematic analysis. Results indicate the presence of three main types of men’s behaviour: 1) participants with positive attitude towards one’s health and practice of health behaviour, 2) well-informed participants with intentions to perform health behaviour as well as excuses not to follow these intentions, 3) men with negative attitude towards one’s health and lack of practice of health behaviour.
PSYCHOMETRIC PROPERTIES OF THE ANOMIA QUESTIONNAIRE (AQ)
Authors: Ļevina Jeļena , Mārtinsone Kristīne
Published: May 2017

The purpose of this research was to develop the Anomia Questionnaire (AQ), which measures different dimensions of anomia and is based on the Levina, Martinsone, and Kamerade (Ļevina, Mārtinsone, & Kamerāde, 2015c, 2016a) integrative multidimensional model of anomia, as well as to determine its psychometric properties. The AQ was developed in Latvian. The sample consisted of 210 Latvian inhabitants aged from 19 to 58 years (27.6 % male, 72.4 % female). The factorial validity of the AQ was established using principal components analysis with Varimax rotation; this yielded six factors, which can be interpreted as Social Distrust (C1), Lack of Goal Clarity (C2), Generalized Sense of Meaninglessness (C3), Cultural Isolation (C4), Deviation from Prescribed Rules or Customs (C5), and Estrangement to Others (C6). All the AQ scales had high internal consistency (Cronbach’s alpha varied from .73 to .86). The reaction and discrimination indices satisfied the accepted psychometric criteria. The further stage of the AQ development would be the confirmatory factor analysis in broader international sample, the concurrent and convergent validity establishing, and test-retest reliability examination.
BUILDING STUDENT ENGAGEMENT IN TEACHING AND LEARNING: AREAS FOR ENHANCEMENT
Authors: Krouglov Alex
Published: May 2017

The paper analyses the engagement of students and teachers in developing a community of practice and the role of the institution in the process. Our research is based on surveys of students and teachers conducted in 2016 as part of the EU-funded Erasmus+ research project Internationalisation and Modernisation of Education and Processes in the Higher Education of Uzbekistan (IMEP). The questionnaires, developed by the project team of researchers, aimed to identify the areas of successful student engagement and where students did not engage actively in teaching, learning and other university and extracurricular activities. Our surveys of students and teachers provided us with the necessary information in order to establish the reasons for successful and less pro-active engagement of students. The results of the surveys also showed some differences in the level of engagement of teachers and students in the process of teaching and learning and how both groups viewed their involvement and the role of the institution. Two case studies presented by students selected for this project showcase their positive experience and confirm the results of our study. While the article deals with concrete data collected and analysed as part of the research, it addresses wider issues of student engagement, the provision of feedback and analyses the role of the main players in the process of teaching and learning enhancement.
DEVELOPMENT OF PROFESSIONAL-PEDAGOGICAL MOTIVATION OF FUTURE TEACHERS IN THE CONDITIONS OF THE INTEGRATED EDUCATIONAL AND PROFESSIONAL SPACE
Authors: Chekina Alena , Vilchynskaya Liudmila
Published: May 2017

The article is devoted to consideration of a problem of modernization of vocational training of future teachers by strengthening of its practical orientation. One of solutions of this problem is designing of the new educational space based on close interaction and integration of resources of university and organizations-customers of specialists. In article the author's model of the integrated educational-professional space of training of teachers is characterized. This model including a number of the interconnected components: target, structural, resource, substantial, procedural-activity and productive. The professional-pedagogical motivation at future teachers was studied by means of "Self-assessment of Professional-Pedagogical Motivation" by N. P. Fetiskin. This tool allows to define at what step of a motivational ladder there is a student: from indifference to future profession to the professional need to seize bases of pedagogical skill.
PREDICTORS OF THE SENSE OF BELONGING TO THE COUNTRY: EXPLORING A NEW MODEL
Authors: Koļesovs Aleksandrs , Melne Ieva
Published: May 2017

This study explored new possibilities for measuring the sense of belonging to the country and investigated predictors of the sense of belonging to Latvia. Focusing on students’ sense of belonging to the country is explained by two reasons: 1) emigration is the main factor of depopulation in Latvia; 2) students’ intention to emigrate is the highest among other social groups. Studies in the field of community psychology present models of the sense of community and explore intentions to stay in a particular place. Within a new model, different levels of social systems (from meso- to macro-system) were included into the analysis of predictors of the sense of belonging to the country. The participants were 205 university students from 18 to 30 (67% females). On the basis of previous studies, a new measure of the sense of belonging and perceived context was developed. The results confirmed a complex model of the sense of belonging in the context of social systems. Higher perceived opportunities at the level of the country and more positive evaluation of the future of Latvia predicted higher level of the sense of belonging to Latvia directly. In addition, female students perceived higher level of the sense of belonging than male students.
ADVANCED TEACHING METHODS FOR STUDENTS’ COMPETENCIES DEVELOPMENT
Authors: Bierne Jekaterina , Titko Jelena , Cerkovskis Edgars , Lasmane Anita
Published: May 2017

Competence-based approach to study process is frequently discussed topic among academicians, learners and government authorities due to its practical contribution to better graduates’ employment abilities. The aim of the given study is to identify teaching methods with the biggest contribution to development of students’ competencies. Bachelor level students of management-based study courses were surveyed in order to evaluate the progress in acquiring certain management competencies. Self-evaluation study was performed before and after the course. The acquired data was processed and the contribution of analysed teaching methods to competencies’ development was assessed.
INTEGRATION OF ENTREPRENEURSHIP INTO HIGHER EDUCATION (EDUCATIONAL SCIENCES) IN LITHUANIA AND LATVIA: FOCUS ON MODERN PEDAGOGICAL APPROACHES
Authors: Melnikova Julija , Zaščerinska Jeļena
Published: May 2017

The purpose of this article is to highlight the aspects of integration of entrepreneurship into higher education (Educational sciences) in Lithuania and Latvia. The article examines the nature of challenges for entrepreneurial teaching and explains how experience-based pedagogies can develop learning environments that replicate aspects of entrepreneurship. The article describes the empiric study, which explored 32 student and 16 university lectures’ opinion on entrepreneurship in Educational sciences. The implications of the article could be useful for university educators, who seek to educate students most effectively with a real intention to become entrepreneurs.
INTERACTIVE TECHNOLOGIES AS A MEANS OF FORMATION OF COMMON CULTURAL AND PROFESSIONAL STUDENTS’ COMPETENCIES IN PEDAGOGICAL INSTITUTES
Authors: Zhestkova Elena , Gubanichina Elena , Oparina Svetlana , Sidorskaya Viola , Gusev Dmitriy
Published: May 2017

The article describes the interactive forms and technologies that contribute to the formation of common cultural and professional competencies in students in pedagogical high school. Interactivity - is "the ability to interact with or be in the mode of dialogue" When traditional methods of teaching dialogue is possible only as the interaction between "teacher - student" and "teacher - student group (audience)", then the interactive learning in addition to this dialogue is constructed as the interaction "disciple - disciple" (work in pairs), "student - student group" (group work), "student - audience" or "group of students - the audience" (presentation of group work), "student - computer", "student - a work of art. According to the authors, the implementation in practice of the Higher School of interactive teaching methods improve the efficiency of the educational process, will teach students on the basis of acquired knowledge, not only to deepen the understanding of the theory, but also to solve the problematic issues, to analyze complex teaching situations, to work together, allow to enrich their own experience , to develop the necessary common cultural and professional competence of future teachers, and most importantly - ensures successful operation and competitiveness of graduates in their chosen professional field.
INDIVIDUAL VALUE SYSTEM CHARACTERISTICS AND DRIVING BEHAVIOR RELATIONSHIPS
Authors: Lazdiņš Krists Jānis , Mārtinsone Kristīne
Published: May 2017

The aim of research was to examine characteristics of individual value system prediction for driving behavior. It raised fundamental question for the research: 1. which of the individual value system characteristics predict driving behavior controlling gender and age. In the study participated 108 respondents, 40 (37.0%) men and 68 (63.0%) women who filled the questionnaire on the internet. There was used two questionnaires – „Latvian driving behavior survey”, The value and levels of availability relations in different spheres of life” The results showed that the value system integrity / disintegrity indicator predicts distracted driving, explains 18% of variation and is statistically significantly. Internal vacuum and age statistically significantly negatively predicts risky driving explaining 17% of variation. Age statistically significantly predicts safe and courteous driving, explains 12% of variation. Value system integrity / disintegrity indicator and gender, statistically significantly negatively predicts summary indicator of dangerous driving, explains 22% of variation. Age statistically significantly negatively predicts distracted driving, explains 30% of variation. Limitations of the research are related to the size of the sample, alignment of participants and use of new instruments, as well as data collection method. If the study would be repeated in the future, it would be desirable to increase the sample size and use approbated instrument. It would be interesting to find out how the value of individual factors predicts objective size of accidents and violations caused by driving. The results can serve as the basis to create new driving behavior interventions and also applicable to psychologist's professional work, when counseling individuals of this group, as well as can be used in the future development of the field, science and research.