bluuebunny/crossref_metadata_2025 huggingface dataset:
Impact of Roux-en-Y Gastric Bypass on the Evolution of Fibrotic NASH: One-Year Follow-Up
Authors: Matavelli Christian Bornia , Echeverria Luisa Souza , Pereira Luca Maunsell , Chrispim Isadora , Mounzer Daniel Leandro Saran , Chaim Felipe David Mendonça , Chaim Elinton Adami , Utrini Murillo Pimentel , Gestic Martinho Antonio , Callejas-Neto Francisco , Cazzo Everton
Published: December 2024

Background: Non-alcoholic fatty liver disease (NAFLD) includes simple steatosis and non-alcoholic steatohepatitis (NASH), with fibrosis in NASH serving as a critical prognostic marker.
Objective: This study investigates the effects of Roux-en-Y gastric bypass (RYGB) on fibrotic NASH, assessed using the Fibrotic NASH Index (FNI).
Methods: A retrospective cohort study was conducted involving 104 individuals (91.3% female, mean age 39.4 ± 8.6 years) who underwent RYGB. Histopathological evaluations during surgery identified fibrotic NASH, and FNI scores were calculated at baseline and one year post-surgery.
Results: At the time of surgery, participants had a mean BMI of 35.3 ± 2.8 kg/m², which decreased to 27.1 ± 4.0 kg/m² one year after surgery. The mean % total weight loss (%TWL) was 23.8 ± 10.1%, and the mean % excess weight loss (%EWL) was 82.4 ± 37.3%. Fibrotic NASH was present in 17.3% of participants pre-operatively. The mean FNI score decreased significantly from 0.16 to 0.07 (p<0.0001) after surgery. Factors associated with improvement in the FNI included female gender (p=0.0009), higher alanine aminotransferase (ALT) levels (p=0.02), presence of lobular inflammation (p=0.03), and pre-operative histological evidence of fibrotic NASH (p=0.04). The FNI demonstrated high diagnostic accuracy (sensitivity: 61.1%, specificity: 96.4%, overall accuracy: 90.2%).
Conclusion: RYGB effectively promotes the resolution of fibrotic NASH, highlighting its potential as a therapeutic intervention to mitigate progression to cirrhosis and hepatocellular carcinoma. The FNI is a reliable, non-invasive tool for assessing fibrotic NASH, warranting further research on its long-term impact on liver health.
Influence of cadmium chloride acute exposure on Alzheimer’s disease in rats: cytotoxicity and genotoxicity aspects
Authors: Essa Marwa Ashraf , Aboul-Ela Ezzat Ibrahim , Ibrahim Muhammad A. , Ibrahim Iman Hassan
Published: December 2024

Exposure to heavy metals poses grave environmental threats, with cadmium (Cd) being a particular concern. This study aimed to investigate the cytogenotoxicity effects of cadmium chloride (CdCl2) in an Alzheimer's disease (AD) rat model. Forty rats were divided into four groups: normal control, Cd-only, AD control, and AD + Cd. The AD groups received lipopolysaccharide (LPS) injections to induce the disease, while the Cd-only and AD + Cd groups received a single CdCl2 injection (3.5 mg/kg body weight). Behavioural, biochemical, and genetic analyses were conducted, along with histopathological examination of the hippocampus and cytogenetic assays on bone marrow cells. The results revealed that Cd exposure significantly impaired locomotor activity, increased acetylcholinesterase (AChE) gene expression, and elevated malondialdehyde (MDA) and catalase (CAT) levels in the AD + Cd group compared to the other groups. Histopathological analysis showed substantial hippocampal damage in the AD + Cd group. Furthermore, Cd significantly increased the frequency of micronuclei and chromosomal aberrations in the AD + Cd group, indicating heightened cytogenotoxicity. In conclusion, acute Cd exposure in an AD context can have detrimental effects at multiple levels, including behavioural, biochemical, histological, and genetic. These findings underscore the importance of understanding the interactions between environmental toxicants and neurodegenerative diseases to develop effective preventive and therapeutic strategies.
The application value of couch height-based positioning in postoperative adjuvant radiotherapy for breast cancer
Authors: Shang Zaichun , Chen Jian , Li Ming , Ge Binbin , Feng Jinjin , Jin Jianhua , Wu Jianting , Ji Hanzhen , Chu Kaiyue , Zhang Xinhua
Published: December 2024

The purpose of this study is to explore the application value of positioning based on the treatment couch height in radiotherapy for left-sided breast cancer. Sixty patients who had undergone radical mastectomy for left breast cancer were selected, with each patient undergoing positioning based on the treatment couch height (couch height group) and positioning based on the reference marking lines (reference line group), to obtain the corresponding positioning errors. Meanwhile, 20 of 60 patients were randomly selected, and the planning system was used to simulate the changes in radiation doses in planning target volume (PTV) and organs at risk (OAR) along with the changes in positioning errors in dorsal (increasing couch height) and ventral (decreasing couch height), respectively. Compared with the original plan, when the positioning error in the dorsal direction reached 3mm, Dmean, V30, and V20 in The ipsilateral lung were increased by 35.12%, 16.35%, and 10.6% respectively, and V50 in PTV was decreased by 0.99% (all p < 0.05); when the positioning error in the ventral direction reached 1.5 mm, V50, V48, and V45 were decreased by 2.07%, 0.58%, and 0.14% respectively. The homogeneity index (HI) was increased by 14.28% (all p < 0.05). There was a statistically significant difference in the positioning errors in the ventral-dorsal directions between the couch height group (0.16±0.14 cm) and reference line group (0.36±0.25 cm) (p < 0.05); the percentages of the absolute positioning errors within 1.5mm and 3mm were 52.4%, 88.7% respectively in the couch height group and 29.8%, 54.4% respectively in the reference line group, (all p < 0.05). Dorsal positioning errors greater than 3 mm significantly worsen the dose distribution for both the PTV and OAR, while positioning based on the treatment couch height keeps 88.7% of positioning errors within 3 mm; ventral positioning errors greater than 1.5 mm result in significant changes in the dose within the PTV. Compared to the reference line group, positioning based on the treatment couch height controls 52.4% of positioning errors within 1.5 mm. Therefore, couch height positioning demonstrates greater advantages in managing ventral-dorsal positioning errors. This study provides a reference for clinical positioning in postoperative adjuvant radiotherapy of breast cancer.
Keywords: Breast cancer radiotherapy, Positioning error, Treatment couch height, Dose distribution
KIFC1 is a potential therapeutic target and prognostic biomarker for renal papillary cell carcinoma
Authors: Chen Binghai , Zhang Wentao , He Jun , Zhang Wenzheng , Zou Yuanzhang
Published: December 2024

Kinesin family member C1 (KIFC1) is a negative end oriented motor protein involving in supernumerary centrosome clustering and has been revealed to function as a novel target and/or prognostic indicator for multiple tumor types. However, the clinical significance of KIFC1 in renal papillary cell carcinoma (KIRP) has not been clearly established. In this study, we firstly analyzed the expression level of KIFC1 in KIRP and normal tissues by using the TCGA, GSE180777 and immunohistochemical staining assay. Subsequently, we compared the expression of KIFC1 in different clinicopathological features and assessed the role of KIFC1 in pRCC cell viability. Then, the clinical value of KIFC1 in diagnosis and prognosis and its relationship with immune cell infiltration in KIRP was analyzed. Lastly, the potential signaling pathway through which KIFC1 may contribute to the progression of KIRP was analyzed using GSEA. The results showed that the expression of KIFC1 was significantly increased in KIRP tissues compared with normal kidney tissues. Specially, the expression of KIFC1 in the patients with advanced stage was higher than those with early stage. The in vitro experiment result indicated that KIFC1 knockdown effectively decreased pRCC cell viability. ROC curve analysis suggested that the AUC value of KIFC1 in TCGA and GSE180777 dataset was 0.793 and 0.817, respectively. Survival analysis results showed that the higher KIFC1 expression, the lower overall survival, disease-specific survival, progression-free interval, and disease-free interval of patients. Immunoinfiltration analysis showed that KIFC1 expression was positively correlated with the infiltration abundance of B cells, CD4+T cells, CD8+T cells, neutrophils and dendritic cells, while negatively correlated with the infiltration abundance of macrophages. The results of GSEA analysis showed that KIFC1 was mainly involved in Oxidative phosphorylation, Collecting duct acid secretion, Valine, leucine and isoleucine degradation, Propanoate metabolism, Citrate cycle (TCA cycle), Glyoxylate and dicarboxylate metabolism in KIRP. In conclusion, KIFC1 was highly expressed in KIRP, and its expression level was closely related to the progression, prognosis and immune cell infiltration, indicating KIFC1 could be used as a potential therapeutic target and prognostic marker for KIRP.
Survival of Total Knee Arthroplasty in Patients with Parkinson's Disease: A Registry Study
Authors: Panciera Alessandro , Martino Alberto Corrado Di , Bordini Barbara , Amabile Marina , D'Agostino Claudio , Digennaro Vitantonio , Faldini Cesare
Published: December 2024

Purpose
This study compared the demographics and outcomes of patients with Parkinson's disease (PD) undergoing total knee arthroplasty (TKA) to those without PD. Additionally, it aimed to assess the impact of implant design on TKA survival in PD patients.
Methods
Using data from the Emilia Romagna Registry of Orthopedic Prosthetic Implants, 551 TKA procedures in patients with PD were identified and compared to 52,022 TKAs in patients without PD. Kaplan-Meier survivorship analysis was used to compare implant survival, with revision surgery as the endpoint. Cox multivariate analysis was performed to assess the influence of age, gender, PD diagnosis, and implant design on implant failure.
Results
The average age of PD patients was 72.2 years, with 66.2% being female. Implant survival was significantly lower in the PD group compared to the control group (p<0.001). At 13 years, the survival rate was 88.8% in the PD group and 94.3% in the control group. PD patients had a 2.7 times higher risk of implant failure after adjusting for age and gender. Constrained implant designs were associated with a 1.7 times higher risk of failure compared to non-constrained designs in PD patients.
Conclusion
PD negatively affects implant survival in patients undergoing TKA. Careful consideration should be given to patient selection and implant design in this patient population.
Prognostic biomarker GOLM1 correlated with immune infiltrates in Endometrial cancer
Authors: Wang Hui , Luo Xiaodong , Hu Jianguo
Published: December 2024

Background
Endometrial cancer (UCEC) is a prevalent gynecological cancer that affects women’s reproductive organs. While studies indicate that GOLM1 may influence the immune response through the tumor microenvironment, its exact roles and mechanisms in UCEC are still not well understood. This study examines the varied expression levels of GOLM1 in UCEC and investigates the relationship between GOLM1 expression and the prognosis of patients with UCEC.
Methods
In this study, we analyzed data from the TCGA database. We utilized several bioinformatics methods, such as differential gene expression analysis, Kaplan-Meier survival analysis, gene set enrichment analysis, and immune cell infiltration analysis. These bioinformatics methods systematically integrate clinical data, gene expression, and immune information, offering a comprehensive view of the molecular mechanisms underlying UCEC.This study employed the software tools TCGA, GEPIA, TIMER, and MethSurv.
Results
GOLM1 mRNA levels were significantly elevated in UCEC tumor tissues. A strong association was found between GOLM1 expression and overall survival in UCEC patients. Enrichment analysis showed that GOLM1 is linked to several biological pathways, including dynein-bound intraflagellar transporters, fatty acid metabolism, and the transcriptional regulation of pluripotent stem cells. Based on these associations, GOLM1 likely plays an important role in the immune microenvironment of UCEC. Furthermore, GOLM1 expression may be influenced by DNA methylation.
Conclusions
GOLM1 is crucial for UCEC, as its levels significantly influence both the occurrence and progression of the disease. GOLM1 and its related genes are potential immunotherapeutic targets for UCEC. Additionally, DNA methylation may regulate the expression of GOLM1 in patients with UCEC.
Developing a prediction model for in-hospital mortality in sepsis patients with gastrointestinal bleeding using the MIMIC-IV database
Authors: Yao Fengwei , Luo Ji , Ming Yue , Zhao Zhiqiang , Wang Luhua , He Zhijun
Published: December 2024

Background: Sepsis associated with gastrointestinal hemorrhage is a critical condition in ICU patients, significantly impacting mortality rates. This study aimed to develop a predictive model for in-hospital death risk in sepsis patients with gastrointestinal bleeding, improving treatment strategies and resource allocation.
Methods: In a retrospective investigation of patients with sepsis and gastrointestinal bleeding, we gathered information from the MIMIC-IV database, including key demographics, comorbidities, laboratory indicators, and therapies.
The dataset was split 70:30 for model development and validation. The Least Absolute Shrinkage and Selection Operator (LASSO) approach was used to select features, and multivariate logistic regression was then used to create a prognostic model. A nomogram was created to visualize predictive outcomes. Model performance was evaluated using calibration curve, receiver operating characteristic (ROC) curve, clinical impact curve (CIC), and decision curve analysis (DCA).
Results: Nine significant predictors of in-hospital mortality were identified: APS III score, prothrombin time, body temperature, activated partial thromboplastin time, respiratory rate, vasopressor use, acute kidney injury, non-invasive ventilation, and malignancy. Area beneath the ROC curve for the training and testing groups
The values are 0.8266 (95% CI: 0.8018-0.8515) and 0.7961 (95% CI: 0.7577-0.8345), respectively. Our model outperformed the APS III score in terms of ROC curve discrimination and demonstrated greater net benefit on the DCA curve. The CIC showed strong concordance between predicted and actual in-hospital death rates when the predicted probability exceeded 70%.
Conclusion: We developed a robust predictive framework for assessing in-hospital death risk in sepsis patients with gastrointestinal hemorrhage. Early intervention based on identified risk factors could improve patient survival rates.
BACE2 is a prognostic biomarker and induced macrophage M2 polarization in Non-Small Cell Lung Cancer
Authors: Feng Yuanyuan , Zhou Xiaohan , Yang Kaifan , Zhu Ziyan , Liu Shuyi , Liu Jiabin , Zhou Jing , Deng Wenxiang , Xu Ziang , He Luhang , Song Miao , Wang Hongmei , Cai Longmei , Lin Yanling
Published: December 2024

BACE2 has gained attention for its upregulation in various human cancers, suggesting relevance in cancer biology. However, its specific role in tumor growth and the tumor immune microenvironment (TIME) remains underexplored. We conducted bioinformatics analyses using pan-cancer datasets to assess BACE2 expression patterns and its correlation with patient outcomes. Additionally, we investigated associations with immune-related genes and immune cell infiltrations in tumor microenvironments. A BACE2 knockdown lung cancer model was established to evaluate its impact on Sorafenib efficacy and PD-L1 inhibitor-induced antitumor immune responses. BACE2 was significantly upregulated in multiple cancers compared to normal tissues and associated with poorer patient outcomes. It played a critical role in modulating immune-related gene expression and promoting immune cell infiltrations within tumors. In vitro and in vivo experiments showed that BACE2 knockdown inhibited M2 macrophage polarization, suppressed lung tumor progression, and enhanced Sorafenib efficacy by increasing activated immune cell infiltrations. Similarly, BACE2 knockdown potentiated PD-L1 inhibitor-induced antitumor immune responses in lung cancer models. This study underscores BACE2's pivotal role in lung cancer tumorigenesis and its influence on the tumor immune microenvironment. Inhibiting BACE2 could enhance current treatment effectiveness in lung cancer therapy, offering promising avenues for improving patient outcomes.
Investigating the Combined Effect of Triglyceride-Glucose and Chinese visceral adiposity Index on Cardiovascular Diseases Risk in Middle-aged and Older Adults: A Cohort Study
Authors: Chen Xueyu , Qiao Junpeng , Zhu Nannan , Pang Jinhong , Fei Haicheng , Liu Zhang , Cheng Fang , Shi Fengxue , Jia Hongying
Published: December 2024

Background:
Cardiovascular diseases (CVDs) have become a significant public health issue, with a strong link to insulin resistance (IR). the triglyceride-glucose (TyG) index and Chinese visceral adiposity index (CVAI) are key indicators in the development of obesity and IR. However, few studies have examined the association between combined TyG and CVAI levels and CVDs.
Methods:
This cohort study base on the China Health and Retirement Longitudinal Study (CHARLS) from 2012 to 2020, ultimately including 6,871 and 3,913 participants to examine baseline and follow-up changes in TyG-CVAI and its association with CVDs, respectively. Participants were divided into four groups based on quartiles and into three classes based on changes in TyG-CVAI using K-means cluster analysis. Multivariable Cox regression analysis was conducted to assess the association between different TyG-CVAI groups and the risk of CVDs. The predictive effect of TyG-CVAI on CVDs was visualized using an ROC curve.
Results:
CVDs incidence was highest in the Q4 and Class 3 groups of TyG-CVAI, with rates of 33.0% and 36.74%, respectively. High baseline TyG-CVAI levels and persistently elevated TyG-CVAI levels are both significantly associated with an increased risk of CVDs incidence, with HRs and 95% CIs as follows:1.61(1.35–1.93),1.68(1.38–2.05), respectively. Persistently elevated TyG-CVAI levels are associated with a higher risk of CVDs incidence, with corresponding HRs and 95% CIs for TyG-BMI and TyG-WHtR at 1.49 (1.23–1.80) and 1.43 (1.17–1.75), respectively. TyG-CVAI demonstrates superior predictive performance for CVDs, CHD, and stroke, with AUCs of 0.594, 0.587, and 0.603, respectively.
Conclusion:
Monitoring long-term changes in TyG-CVAI may provide a novel scientific basis for early risk identification in CVD prevention among middle-aged and elderly individuals in China.
Diarrhea control using low-methoxyl pectin-containing enteral nutrition.
Authors: Tanaka Makoto , Akiyama Ryosuke , Yamaoka Ippei
Published: December 2024

Background
Diarrhea is the most common side effect of enteral nutrition and can lead to incontinence-associated dermatitis and malabsorption, indicating an unmet medical need for patients receiving enteral nutrition. Diarrhea related to enteral nutrition often occurs in conjunction with antibiotic use, highlighting the complexity of nutritional management and infection control. Here, we report an approach to address unmet medical needs by using low-methoxyl pectin-containing liquid diets, reconciling diarrhea control and antibiotic management.
Methods
Dysbiosis was induced in rats through a 4-week administration of an antibiotic cocktail added to drinking water. Different liquid diets, including fiber-free, low-methoxyl pectin, and partially hydrolyzed guar gum-containing formulas, were administered for 7 days using a gastric fistula. Fecal scoring and cecal histopathological examinations were conducted.
Results
The group administered a low-methoxyl pectin-containing liquid diet exhibited normal feces throughout the administration period that did not deteriorate with dysbiosis; additionally, mucosal atrophy was histopathologically suppressed. In contrast, fecal appearance deteriorated chronologically in the other liquid diet groups and worsened further with dysbiosis; frequent and strong villous atrophy was also observed.
Conclusions
A liquid diet containing low-methoxyl pectin controlled diarrhea in rats with antibiotic-treated dysbiosis. The mechanisms behind the improved fecal characteristics were attributed to the absorption of water and the inhibitory effect of dietary fiber on mucosal atrophy through stool formation. We hope to address these unmet medical needs through the use of low-methoxyl pectin in clinical settings in the future.
Cognitive on Prevention of Work-Related Musculoskeletal Disorders among Nurses in Shandong Province of China: A cross- sectional study
Authors: Yang Hailing , Cheng Yuepeng , Zhang Xu , Lin Hui , Basilio Pia Vanessa , S.Calibjo Mylene , Ma Aixia
Published: December 2024

Background
Work-related musculoskeletal disorders (WMSDs) have become major occupational health problems worldwide. Last year, 91.2% of nurses reported experiencing WMSDs in at least one region of their body. However, this issue has not received adequate attention among nurses. This study aims to determine the frequency of WMSDs and assess nurses' knowledge, attitudes, and practices regarding self-protective behaviors.
Methods
A cross-sectional study was conducted in March 2024 among full-time registered nurses from various departments in hospitals across Shandong Province, China. Demographic data, the Nordic Standardized Musculoskeletal Questionnaire, and questionnaires on knowledge, attitudes, and behaviors related to protection were used.
Results
A total of 697 nurses participated, 93.7% of whom were female and 87.7% who held a bachelor's degree or higher. The prevalence rates of WMSDs were 94.98% (historical), 93.11% (annual), and 87.37% (weekly), which are higher than those reported in relevant studies from Xinjiang. The top five affected body parts were the waist, neck, shoulders, back, and wrist. The WMSD prevalence was higher in women (96.02%) than in men (20.45%) and was highest among nurses aged ≥ 41 years and those with 16–20 years of experience (98.01% and 98.90%, respectively). Married nurses and those with a BMI ≥ 32.0 kg/m2 had prevalence rates of 95.85% and 100%, respectively. The factors significantly associated with WMSDs included sex, age, years of work, marital status, educational background, BMI, working hours, knowledge, and protective behaviors. The study revealed that 31.3% of nurses lacked knowledge about WMSDs, 65.1% reported no relevant training in their hospitals, and 90.7% were willing to participate in such training.
Conclusion
The prevalence of WMSDs among nurses in Shandong Province is high, with multiple body parts affected. Binary logistic regression analysis identified long periods of standing and lifting weights with one hand as risk factors. Strong protective behavioral abilities serve as a protective factor. This study highlights the need for increased attention and timely interventions from nursing managers.
Where there is no specialist – Improving Mental Health Literacy of Frontline Community Health Workers in a Rural District of Pakistan: The mPareshan Project
Authors: Akhtar Samina , Rabbani Fauziah , Nafis Javeria , Merali Zul
Published: December 2024

Background
In low- and middle-income countries (LMICs), four out of five people with mental illness do not receive specialized treatment. Utilizing non-specialist frontline workers to deliver basic mental health services at the community level therefore needs to be explored.
Aims
This study assessed improvement in knowledge and skills of frontline community workers in identifying symptoms of anxiety and depression, making appropriate referrals, and providing psychosocial counselling in a rural district of Pakistan.
Methods
Project mPareshan developed a training manual to improve mental health literacy of government’s Lady Health Workers (LHWs) and Lady Health Supervisors (LHSs). The content was adapted from WHO mhGAP 2.0 intervention guide to suit the local context. 72 LHSs and LHWs (36 each) from District Badin, Sindh, Pakistan received the training. A pre- and post-test was conducted to assess the change in knowledge and skills of participants using paired sample T-tests.
Results
The overall mean knowledge score of all participants increased significantly from 4.37 (SD = 1.45) before the mPareshan mental health literacy training, to 9.02 (SD = 1.48) after training (p < 0.01). The overall mean skills score for all participants was 8.07 (SD = 2.14) at pre-test and reached 9.84 (SD = 0.63) in post-test (p < 0.01). Mean scores of LHSs’ knowledge and skills were higher in most domains compared to LHWs.
Conclusions
This training in mental health has the potential to improve the overall knowledge and competencies of community health workers. Such endeavours can be upscaled so that frontline workers can serve as a useful workforce in the absence of specialist mental health services.
Evaluating Lead-Based vs. Lead-Free Perovskites for Environmentally Sustainable Indoor Photovoltaics
Authors: Clegg Charlotte , Mei Jianjun , Fuensanta Aitana Uclés , Ibn-Mohammed Taofeeq , Pecunia Vincenzo
Published: December 2024

Indoor photovoltaics (IPVs) based on halide perovskites (HPs) and derivatives (HPDs) hold great promise for powering the vast infrastructure of Internet-of-Things (IoT) smart devices. While lead-containing IPVs deliver cutting-edge performance, environmental concerns have spurred research into lead-free alternatives. However, the environmental sustainability of these IPV technologies remains underexplored, with the lead-based versus lead-free debate confined to elemental considerations, neglecting life-cycle impacts and IPV requirements. This study presents the first comparative life-cycle assessment (LCA) addressing the lead-based vs. lead-free HP/HPD IPV dilemma, examining the environmental sustainability of absorbers, precursors, functional layers, and fabrication steps. A modelling framework is introduced to evaluate the net environmental gains (NEGs) of IPVs compared to the conventional battery-centric approach for powering smart devices. Our findings challenge conventional assumptions that lead-free HP/HPD IPVs are inherently more eco-friendly than their lead-based counterparts. Moreover, we demonstrate that Pb- and Sn-based IPVs can achieve NEGs after just 3–4 weeks and 4–7 weeks, respectively, significantly outperforming mainstream IPVs. In contrast, the NEGs of Sb- and Bi-based IPVs align with mainstream IPVs, limiting their potential unless efficiencies increase to ~40%. Key strategies to enhance the eco-friendliness of HP/HPD IPVs and policy considerations on Pb-based IPVs for IoT sustainability are outlined.
Daring Activation Energy: Environmental Design for Accelerated Learning and Intrinsic Motivation in Primary Education
Authors: Kalmakov Oleg A.
Published: December 2024

This study introduces and validates the concept of "daring activation energy" - a distinct motivational-cognitive state that emerges under specific environmental conditions in primary education. Through a year-long experiment involving four experimental classes (N = 93) with corresponding control groups, we demonstrate how systematic environmental redesign enables extraordinary learning engagement and accelerated cognitive development, with experimental groups showing significant IQ gains (∆=6 points, p < .01) and remarkable learning acceleration. These outcomes were achieved through minimal intervention (10% of academic time), suggesting efficient transformation possibilities within existing educational systems. Our findings extend Self-Determination Theory by demonstrating how institutional structures can systematically support intrinsic motivation emergence, offering both theoretical framework and practical evidence for transforming educational practice.
Ответ-адаптированная стратегия терапии первичной медиастинальной В-крупноклеточной лимфомы: результаты проспективного одноцентрового клинического исследования
Authors: Мангасарова Яна Константиновна , Абдурашидова Р. Р. , Магомедова А. У. , Марголин О. В. , Нестерова Е. С. , Горенкова Л. Г. , Багова М. О. , Фастова Е. А. , Белкина Д. С. , Ковригина А. М. , Габеева Н. Г. , Королева Д. А. , Кравченко С. К. , Чабаева Ю. А. , Звонков Е. Е.
Published: December 2024

BACKGROUND. Up to now, neither the optimal treatment regimen for primary mediastinal large B-cell lymphoma (PMBCL), nor poor/favorable prognostic factors for risk stratification at the disease onset have been found. The prognosis of PMBCL is determined by the depth of metabolic response by the time of treatment completion, which underlies a response-adapted strategy. Besides, PMBCL is an aggressive tumor occurring more commonly in young women of reproductive age, which requires the development of treatment strategy during pregnancy.
AIM. To assess the efficacy of the response-adapted strategy in PMBCL treatment based on the DA-EPOCH-R program in remission induction with drug dose escalation and without subsequent radiotherapy, if a complete metabolic response is reported by PET-CT.
MATERIALS & METHODS. This prospective single-center clinical trial enrolled 154 patients in the period from November 2012 to March 2023. The median age of the patients was 34 years (range 19–68 years). There were 51 (33.1 %) men and 103 (66.9 %) women, 11 of whom were at various gestational ages of pregnancy.
RESULTS. The response-adapted treatment was completed in all 154 patients. Overall response was 93.5 % (144/154), complete remission was 78.6 % (121/154), and partial remission was 14.9 % (23/154). Progression was reported in 6.5 % (10/154) of patients. With a follow-up of 60 months, the overall, disease-free, progression-free, and event-free survival rates were 93 %, 98 %, 92 %, and 76 %, respectively. The median was not reached. Prior to chemotherapy, 11 pregnant women aged 21–37 (median 29 years) had been assessed. By the time of PMBCL diagnosis, the gestational age of them varied from 9 to 37 weeks (median 26 weeks). Immunochemotherapy was administered to 9 women during pregnancy. At the gestational age of 27–38 weeks (median 34 weeks) delivery was reported in 10 patients who gave birth to 11 children. The children showed no malformations. All women with PMBCL diagnosed during pregnancy and all their children had been followed-up by the time of this publication.
CONCLUSION. The response-adapted strategy of PMBCL treatment with the DA-EPOCH-R regimen and drug dose escalation showed a high immediate and long-term efficacy as well as tolerable toxicity, which provided ground for the decision against radiotherapy, if a complete metabolic response was reported by PET-CT. The results of this trial establish the main goal of treating aggressive lymphomas during pregnancy which is saving of two lives. Delivery of newborns without malformations despite immunochemotherapy justifies the use of the DA-EPOCH-R program at the gestational age > 12 weeks.
Prevenção da Sífilis Congênita: O Papel da Penicilina na Redução da Transmissão Vertical
Authors: Mesquita Thaiany Martins de Brito , Pessoa Kettlyn Pinto , Gonçalves Fernando Rodrigues , Santos Fabiana dos Reis , Mendonça Ana Carolina da Fonseca , Cardoso Rafaella de Carvalho
Published: December 2024

A sífilis é uma infecção bacteriana causada pelo Treponema pallidum, que pode ser transmitida sexualmente e verticalmente. No Brasil, a sífilis congênita (SC) foi reconhecida como doença de notificação compulsória desde 1986, e sua incidência tem aumentado, afetando principalmente populações vulneráveis. o tratamento com penicilina benzatina é fundamental para prevenir a transmissão vertical, assim como se tornou crucial para reduzir complicações graves, como malformações e morte neonatal, sendo altamente eficaz e acessível, trazendo consigo também a necessidade de um diagnóstico precoce, onde o rastreamento deve ser realizado no primeiro e terceiro trimestre da gestação. Este estudo revisa a relação entre a administração de penicilina em gestantes e a incidência de SC Ressaltando a eficácia da penicilina G benzatina no combate à SC e a necessidade de protocolos rigorosos para triagem e tratamento.
Identifying predictors of consumer willingness to purchase second-hand or rent clothing online
Authors: Šalčiuvienė Laura , Banytė Jūratė , Šeinauskienė Beata , Gadeikienė Agnė , Dovalienė Aistė
Published: December 2024

The most recent developments in the sustainable fashion indicate the need to further study circular consumption. Ethical identity is linked to decision-making as morally correct or incorrect in relation to perceived brand value and demographics of today’s modern consumers. The study focuses on the role of ethical intensity, perceived social and emotional value and demographic characteristics in relation to consumer willingness to rent or purchase second-hand clothing online. The study employed an online survey to collect data in the United Kingdom and Lithuania. These two countries are relevant for this study because they both are situated in Europe. They both have options for consumers to shop second-hand or rent clothing online, which allows for meaningful data comparison. The study’s findings suggest that demographics, that is, gender acts as significant predictors for consumer willingness to purchase or rent second-hand clothing online in both countries, while age is only significant for Lithuania but not for the UK. Ethical intensity is an important driver of consumer willingness to rent or purchase second-hand clothing online in the UK but not in Lithuania. Perceived social and emotional value is the strongest significant predictor in the consumer willingness to rent or purchase second-hand clothing in both countries. By examining the abovementioned drivers, the study contributes to knowledge on how to better predict consumer decision-making. Specifically, the study introduces ethical intensity construct to the online second-hand and rental clothing context to aid the explanation of consumer willingness to purchase second-hand or rent clothing in the online context.
AcknowledgmentThis project has received funding from the Research Council of Lithuania (LMTLT), agreement No [S-MIP-22-27].
Calculation of the Invariant Decomposition of the Tangent Space
Authors:   Lomonosov Moscow State University, Osipenko Georgii Sergeevich , Andreeva Irina Alexeevna ,   Peter the Great St. Petersburg Polytechnic University
Published: December 2024

A discrete dynamic system generated by a diffeomorphism is considered. The task of constructing an invariant decomposition of the tangent space is set. This task is reduced to calculating the components of a chain recurrent set on a projective bundle. A computer-oriented tool for such a calculation is a symbolic image of a dynamic system, which is an oriented graph. The components of the chain recurrent set are determined by calculating the components of the strong connectivity of the symbolic image. A nontrivial example of calculating the desired tangent space decomposition is given.
Compreensões da sexualidade através da lente da psicologia analítica
Authors: Caroline dos Santos Jéssica , Rangel Rossetim de Souza Isadora , Caius Silvestre Paim Juan , Carolina Grabowski de Souza Ana , Teles de Brito Beatriz , Kritski Braz Laisa
Published: December 2024

A presente pesquisa teve o objetivo de responder como a psicologia analítica tem abordado o tema da sexualidade nas suas publicações científicas. O método empregado foi o de revisão integrativa de literatura, com pesquisa realizada nas bases de dados Journal of Analytical Psychology e Portal de Periódicos Capes. Na primeira, foram empregados os descritores: sexuality, analytical psychology e jungian psychology. Na segunda, foram utilizados: sexualidade, psicologia analítica e psicologia junguiana. Resultaram dessa busca oito artigos publicados nos últimos 20 anos e, além deles, acrescentou-se outros trabalhos para a fundamentação teórica. Os temas identificados nos resultados foram: aspectos histórico-culturais na leitura de anima e animus; a potência do simbólico feminino na vivência da sexualidade; psicopatologia e sexualidade; e novas perspectivas arquetípicas sobre a leitura clássica de anima e animus. O estudo aponta em direção a uma revisão dos pressupostos da psicologia analítica no que tange à sexualidade, para a compreensão do seu desenvolvimento e das implicações relacionadas às expressões de gênero. Concluiu-se que o tema necessita de pesquisas que tragam entrevistas e relatos de pacientes na clínica da sexualidade em psicologia analítica para que se possa compreender os sintomas que emergem das relações de poder hegemônicas.
mHealth Apps in German Outpatient Mental Health Care: Protocol for a Mixed Methods Approach
Authors: Höfer Klemens , Plescher Felix , Schlierenkamp Sarah , Solar Stefanie , Neusser Silke , Schneider Udo , Best Dieter , Wasem Jürgen , Abels Carina , Bußmann Anna
Published: December 2024

Background

Mental disorders are complex diseases that affect 28% (about 17.8 million people) of the adult population in Germany annually. Since 2020, certain mobile health (mHealth) apps, so-called digital health applications (DiGA), are reimbursable in the German statutory health insurance system. A total of 27 of the 56 currently available DiGA are approved for the treatment of mental and behavioral diseases. An indicator of existing problems hindering the use of DiGA is the rather hesitant prescribing behavior.

Objective

This project aims to develop health policy recommendations for the optimal integration of DiGA into outpatient psychotherapeutic care. The project is funded by the Innovation Fund of the Joint Federal Committee (grant 01VSF22029). The current status quo of the use of DiGA will be analyzed. Furthermore, concepts for the integration of mHealth apps, as well as their transfer into the care process will be investigated. In addition, barriers will be identified, and existing expectations of different perspectives captured.

Methods

The project will be based on a mixed methods approach. A scoping review and a qualitative analysis of focus groups and expert interviews will be carried out. Additionally, an analysis of claims data of the statutory health insurance will be conducted. This will be followed by a written survey of insured persons and health care providers. Finally, health policy recommendations will be derived in cooperation with stakeholders.

Results

The scoping reviews and qualitative analyses have been completed, and the quantitative surveys are currently being carried out. The target number of responses in the survey of insured persons has already been achieved. Furthermore, the analysis claims data of the statutory health insurance is currently being conducted.

Conclusions

There is a need for research on how DiGA can be optimally integrated into the care process of patients with mental disorders as evidence regarding the topic is limited and prescribing behavior low. Although the potential of DiGA in mental health care has not yet fully unfolded, Germany serves as a model for other countries regarding reimbursable mHealth apps. This project aims to explore the potentials of DiGA and to describe the organizational, institutional, and procedural steps necessary for them to best support mental health care.

International Registered Report Identifier (IRRID)

DERR1-10.2196/56205
The efficacy of hypnotherapy on reducing burnout and related psychopathologies: A protocol of the systematic review and meta-analysis (Preprint)
Authors: Veeramachaneni Santosha , Park Elizabeth , Martin Jeffrey , Ringor Marc , Brown Gregory , Weisman Anne , Batra Kavita
Published: December 2024

BACKGROUND

Hypnosis is a focused state of consciousness that enhances concentration,
attention, and responsiveness to suggestion. It has shown efficacy in treating psychiatric
disorders such as depression, anxiety, and PTSD. However, its potential for addressing burnout
and related symptoms remains underexplored. This systematic review and meta-analysis aims to
assess the effectiveness of hypnotherapy in alleviating symptoms of burnout and associated
conditions, including depression, anxiety, and PTSD.

OBJECTIVE

To evaluate the efficacy of hypnotherapy in treating burnout and its related
psychopathologies, including depression, anxiety, and PTSD.

METHODS

A comprehensive search will be conducted across PubMed, Scopus, and
PsycINFO for peer-reviewed, English-language observational and experimental studies
published up to February 2024. Only studies with adults (18+) who received hypnotherapy for
psychiatric symptoms will be included. Data extraction will focus on treatment effects related to
burnout and associated psychiatric conditions. Statistical analysis will be performed using
Comprehensive Meta-Analysis (CMA, version 3.0). A random-effects model will be used to
account for heterogeneity, with Cochran’s Q and I² statistics to assess variability. Subgroup
analyses will explore moderators such as sociodemographic factors, country, and study quality.
Sensitivity analyses will identify influential studies, and publication bias will be assessed using
funnel plots and Egger’s test. All analyses will be two-sided (p < 0.05), and results will be
presented in forest plots.

RESULTS

Full-text screening will be completed by December 2024, with data
extraction and analysis ending in March 2025. Findings will be finalized and submitted for publication by Summer 2025.

CONCLUSIONS

Hypnotherapy may be a promising adjunctive treatment for burnout and
related psychiatric disorders, offering improved symptom control and well-being.
Sustainable Development and Management Strategies of Groundwater in Arid-Lands
Authors: Freeg Ashraf , Riad Peter , Hassan Nagy Ali , Nassar Ayman A.
Published: December 2024

Sustainable groundwater development efficiently manages existing groundwater resources and addresses the risks associated with aquifer physical qualities, storage capacity, and recovery ability for future generating requirements. Response to future scenario development is essential for sustainable groundwater management in arid lands. This article discusses various development scenarios associated with better management of groundwater. This is to formulate effective and sustainable management strategies and their impact on sustainable groundwater management. The paper also seeks to provide a brief overview of common ideas of sustainability and their application to groundwater resource usage and development. Eventually, sustainable development can be accompanied by policies that stimulate groundwater use and prioritize profit over conservation require being considered. Policies include the establishment and formation of a social identity for collective aquifer storage and recovery, the creation of a legal framework for sustainable groundwater governance, the establishment of social adoption of groundwater pumping technology, and the formation of groundwater cultures at the point of abstraction.
Unveiling the Intersectional Experiences of Women of Color: A Choreopoetic Exploration in For Colored Girls Who Have Considered Suicide/When the Rainbow is Enuf by Ntozake Shange
Authors: Mani J. , Balaji Dr. B.
Published: December 2024

This groundbreaking choreopoem, "For Colored Girls Who Have Considered Suicide/When the Rainbow is Enuf," penned by Ntozake Shange, delves into the intricate tapestry of experiences faced by women of color in America. Through a poignant blend of poetry, dance, and music, Shange gives voice to the silenced narratives of seven women, each representing a distinct color of the rainbow. This seminal work excavates the intersections of racism, sexism, and personal identity, laying bare the struggles and triumphs of women navigating the complexities of a patriarchal society. As a powerful exploration of intersectional feminism, this choreopoem continues to resonate with audiences, offering a testament to the resilience and strength of women of color. The choreopoem's non-linear narrative structure and innovative use of language, dance, and music create a unique and immersive experience for the audience. Shange's masterful storytelling weaves together themes of love, loss, trauma, and empowerment, providing a nuanced and multifaceted portrayal of the lives of women of color. By centering the voices and experiences of these women, Shange challenges dominant narratives and power structures, creating a powerful and enduring work of art. Furthermore, "For Colored Girls Who Have Considered Suicide/When the Rainbow is Enuf," has had a profound impact on American literature and culture, paving the way for future generations of women writers and artists of color. Its influence can be seen in a wide range of artistic and literary works, from the poetry of Maya Angelou and Audre Lorde to the plays of Anna Deavere Smith and Suzan-Lori Parks. As a testament to its enduring relevance and power, "For Colored Girls" continues to be performed, taught, and celebrated around the world.
Review on Harnessing Artificial Intelligence: A Paradigm Shift in Cybersecurity for a Safer Digital Future
Authors: N G Sumanth Goud
Published: December 2024

Artificial Intelligence (AI) is transforming cybersecurity by addressing the limitations of traditional reactive systems,
which often fall short against advanced and unknown threats. By leveraging machine learning, neural networks, and predictive
analytics, AI-driven cybersecurity systems provide proactive and adaptive solutions to modern challenges. These systems
enhance threat detection accuracy, reduce response times, and efficiently manage large-scale, complex networks, making them
indispensable across industries like finance, healthcare, and e-commerce. AI's ability to process vast amounts of data enables
early identification of anomalies and prediction of potential risks, ensuring robust protection against evolving cyberattacks.
However, challenges such as data privacy concerns, algorithmic biases, and the risk of AI misuse must be addressed. Ethical
deployment and collaboration among governments, industries, and academia are critical to overcoming these obstacles. By
fostering transparency and innovation, AI can become a cornerstone of global cybersecurity, paving the way for a safer, more
resilient digital future.
Application of Sanctions for Violations of Mandatory Reporting of Beneficial Owners in Limited Liability Companies
Authors: Lamada Victoria Tabita Majesty
Published: December 2024

This research explores the concept and regulatory framework of Beneficial Owners in Indonesia's corporate governance, focusing on Limited Liability Companies. Beneficial Owners, distinct from registered shareholders, hold significant economic interests in corporations while their identities may not be publicly disclosed. The study traces the historical evolution of the Beneficial Owner concept from medieval proxy arrangements to modern corporate structures. It examines legal instruments such as Presidential Regulation Number 13 of 2018 and Minister of Law and Human Rights Regulation Number 15 of 2019, which mandate transparency in disclosing Beneficial Owners to prevent Money Laundering and Terrorism Financing. However, in reality, there is no specific law that regulates Beneficial Owners, so it is necessary to refer to the considerations for the formation of Presidential Regulation 13/2018 and the Regulation of the Minister of Law and Human Rights 15/2019. Despite regulatory advancements, compliance remains a challenge, with significant proportions of corporations failing to report Beneficial Owners annually. Sanctions, including administrative penalties and criminal liabilities under Indonesian laws, underscore the importance of enforcement to ensure transparency and accountability in corporate governance. The research highlights global implications, emphasizing the role of transparency in combating international financial crimes and promoting ethical business practices worldwide.