bluuebunny/crossref_metadata_2025 huggingface dataset:
GBP4 is an Accurate Diagnostic Biomarker and a Potential Treatment Target for Crohn’s Disease
Authors: Shi Heng , Peng Qin , Zhou Xian-Ling , Zhu Shi-Ping , Sun Sheng-Yun
Published: December 2021

Background: Extensive evidence has shown that immune cell infiltration is associated with the pathogenesis of Crohn’s disease (CD). In the present study, we explored the potential mechanism underlying the pathogenesis biomarkers for CD.Methods: The GSE179285 dataset containing sequence data for intestinal mucosal was downloaded from the Gene Expression Omnibus (GEO) database. Differentially expressed genes (DEGs) in the intestinal mucosa of CD patients and healthy individuals were then identified. The infiltration pattern of 22 immune cell types was assessed using the CIBERSORT algorithm. The DEGs and 22 immune cell types were combined to find the key gene network using weighted gene co-expression network analysis (WGCNA), and pathway enrichment analyzes were performed on the hub module in the WGCNA. A linear regression model for the relationship between the expression of the hub genes in CD patients and infiltration of immune cells were also developed. The utility and accuracy of the hub genes for CD diagnosis were assessed using receiver operating characteristic (ROC) analysis. The accuracy of the model was validated using GSE20881 dataset. Results: There were 1135 DEGs between the intestinal mucosal tissue of CD patients and healthy individuals. Of these DEGs, 711 genes were upregulated, whereas 424 of them were downregulated. There was also a significant difference in the infiltration of immune cells to the intestinal mucosal between the CD patients and healthy individuals. WGCNA revealed that the turquoise module genes were strongly correlated with the infiltration of M1 macrophages (cor=0.68, p=10-16). Pathway enrichment analysis further showed the genes in the turquoise module mainly regulated the secretion of interferon-gamma and other immune effector molecules. Finally, the expression of GBP4, the identified hub gene, strongly correlated with the infiltration of M1 macrophages (adjusted r-squared=0.661, p<2x10-16), and is a relatively good marker for CD diagnostic prediction (AUC=0.736). The relationship between GBP4 expression and infiltration of M1 macrophages (adjusted r-squared=0.435, p<2x10-16) and prognostic value of the gene (AUC=0.702) were verified using the GSE20881 validation dataset.Conclusion: GBP4 is a potential biomarker for accurate CD diagnosis. The expression of GBP4 promotes the infiltration of M1 macrophages to the intestinal mucosa of CD patients.
Inhibitory Effects of LOXL2 Knockdown On Cellular Functions of Liver Cancer Stem Cells
Authors: Li Na , Gu Huan , Liu Liu , Zhang Xiao Li , Cheng Qiu Luo , Zhu Ying
Published: December 2021

Background and aim: Lysyl oxidase-like 2 (LOXL2) plays a role in tumor microenvironment formation and metastasis of hepatocellular carcinoma (HCC), which has a high mortality burden. Liver cancer stem cells (LCSCs) are related with the major malignant phenotypes of HCC. The function of LOXL2 in regulation of LCSCs remains unknown.Methods: CD133+HepG2 and CD133+Hep3B cells were sorted by fluorescence-activated cell sorting (FACS) from two human hepatoblastoma cell lines. Spheroid formation, apoptosis, cell cycle, as well as transwell assays were performed upon LOXL2 knock down in CD133+HepG2 and CD133+Hep3B cells. Protein and mRNA levels were quantified by Western blotting, Immunofluorescence and real-time PCR. Results: Knockdown of LOXL2 decreased spheroid formation, migration and invasion (p < 0.05), also induced apoptosis (p < 0.05) and cell cycle arrest (p < 0.05) in CD133+HepG2 and CD133+Hep3B cells. Knockdown of LOXL2 effectively inhibited expression of the anti-apoptosis proteins baculoviral IAP repeat-containing 3 (BIRC3) and murine double minute 2 (MDM2) (p < 0.01), as well as autophagy marker microtubule-associated protein 1 light chain 3 B (LC3) and autophagy gene ATG5 in CD133+HepG2 and CD133+Hep3B cells (p < 0.01). Conclusions: The results revealed that LOXL2 inhibition could reduce the proliferation and expansion of LCSCs, making LOXL2 inhibitors an attractive and novel therapeutic strategy of HCC.
Research On Arc Fault Detection Using Morlet Wavelet Features And ResNet
Authors: Zhang Shuai , Qu Na , Zheng Tianfang , Hu Congqiang
Published: December 2021

Series arc fault is the main cause of electrical fire in low-voltage distribution system. A fast and accurate detection system can reduce the risk of fire effectively. In this paper, series arc experiment is carried out for different kinds of electrical load. The time-domain current is analyzed by Morlet wavelet. Then, the multiscale wavelet coefficients are expressed as the coefficient matrix. We use HSV color index to map the coefficient matrix to the phase space image. Random gamma transform and random rotation are applied to data enhancement. Finally, typical deep residual network (ResNet) is established for image recognition. Training results show that this method can detect faults in real time. The accuracy of ResNet50 is 96.53% by using the data set in this paper.
Risk Factors for Secondary Glaucoma in Patients with Vogt-Koyanagi-Harada Disease
Authors: Alvarez-Guzman Carlos , Hartleben-Matkin Curt , Ruiz-Lozano Raul E. , Rodríguez-Garcia Alejandro , Quiroga-Garza Manuel E. , Valdez-Garcia Jorge E.
Published: December 2021

Background: To identify the prevalence and risk factors for secondary glaucoma among Mexican-mestizo patients with Vogt-Koyanagi-Harada Disease (VKH). A retrospective cohort study was conducted to identify the risk factors for developing secondary glaucoma based on demographic, clinical, and epidemiological variables of VKH Mexican-mestizo patients. Risk estimates were calculated using a Cox proportional hazards regression model. Main text: One hundred eyes of 50 patients, 44 (88%) women and 6 men (12%) with a median age of 35.5 years (IQR 29 – 46), and a median follow-up time of 72 months (IQR 13.7 – 126.7) were included for analysis. The prevalence of glaucoma was 20%, with angle-closure glaucoma accounting for 70% of all cases. Significant clinical risk factors for glaucoma development were a chronic recurrent stage at presentation (RR 2.88 95% CI 1.11 – 12.63, p=0.037), more than two episodes of recurrent anterior uveitis (RR 8.52 95% CI 2.02 – 35.92, p<0.001), angle-closure disease (ACD, RR 7.08 95% CI 2.44 – 20.48, p<0.001), iris bombé (RR 5.0 95% CI 2.10 – 11.90, p<0.001), and peripapillary atrophy (RR 3.56 95% CI 1.43 – 8.85, p<0.001). Exposure to prednisone for more than 24 months (RR 9.33 95% CI 2.21 – 39.28, p<0.001) or topical corticosteroid drops for more than 12 months (RR 3.88 95% CI 1.31 – 11.46, p=0.007) were associated with an increased likelihood for secondary glaucoma development. Conclusions: Glaucoma is a frequent complication in patients with VKH, often attributed to mixed pathogenic mechanisms. Chronic disease at presentation, recurrent inflammation, angle-closure mechanisms, iris bombé, and peripapillary atrophy represent clinically significant risk factors for secondary glaucoma development. Prompt and aggressive steroid-spearing immunosuppressive therapy for reaching adequate control of inflammation may lower the risk of glaucoma in VKH patients.
Electroretinogram Analysis In Patients With Non-Proliferative Diabetic Retinopathy
Authors: Maleki Zahra , Behbahani Soroor , Ahmadieh Hamid
Published: December 2021

Purpose: Non-proliferative diabetic retinopathy (NPDR) is the earliest stage of diabetic eye disease. Microscopic changes occur in the blood vessels of the eye in NPDR. The changes typically do not produce symptoms and are not visible to the naked eye. This paper aims to investigate a method for distinguishing NPDR based on Electroretinogram (ERG).Method: The ERG responses were recorded in 20 eyes from 14 patients with NPDR and 20 eyes from 20 healthy subjects as the control group. The responses of three standard stimuli were collected for both groups. Time-domain parameters, including amplitudes and implicit time, and a nonlinear criterion, were used to differentiate the groups. Results: This study showed that implicit time and amplitude of b-wave in dark-adapted 10.0 ERG and amplitude and implicit time of light-adapted flicker 30 Hz could distinguish between controls and NPDR groups. Theta values obtained for dark-adapted 10.0 ERG (p=0.0019), light-adapted 3.0 ERG (p=0.0021), and light-adapted flicker 30 Hz (p=0.0023) had significant differences between the groups. Conclusion: The proposed features have made it possible to distinguish between healthy and NPDR eyes. Choosing an appropriate method can effectively evaluate inner retinal dysfunction, especially in diabetic retinopathy.
Evaluating Technological Innovation Impact. An Empirical Analysis of The Offshore Wind Sector.
Authors: Shi Junguo , Hu Xuhua , Dou Shanshan , Alemzero David , Alhassan Elvis Elvis
Published: December 2021

This study analyses the drivers that impact innovation on offshore wind energy for a select group of countries, applying the quantile and GMM approaches for a period between 2010-2019. The OLS results from the quantile analysis say the log of trademark, Carbon emissions, offshore wind capacity, and electricity from renewable energy are significant and impact on innovation regarding offshore wind energy. Generally, the Breusch-Pagan / Cook-Weisberg test for heteroskedasticity test reveals the variables have a constant variance, confirming the robustness of the findings. The quantile regression depicts that at 25th and 75th quantiles levels, the log of trademark, the log of trade flows, the log of scientific and technical journals quantile coefficients is significantly different from zero and exhibit varied effects on the explained variable patent.Similarly, the analysis applied the IV-GMM estimation in ivreg2 to identify the over restrictions, the Hansen J statistic, and give the robust moment of conditions analysis. The findings are consistent with prior analysis with the log of trademark, the log of offshore wind capacity, the log of carbon emissions, Scientific and technology journals, the log of patent, electricity from renewables to be significant and impact on innovation.The robustness was done on the GMM models, by applying the Huber-White-Sandwich estimator of the variance of the GMM linear models approximators. The ivreg2 robust analysis revealed that the estimates are efficient for homoskedasticity and Statistics robust to heteroskedasticity.Ultimately, the interaction term ‘’cross’’ came out significant in the analysis. Signifying the importance of the interaction variables in scaling innovation.This study will sever as a reference document for policy formulators regarding scaling up innovation for offshore wind energy.
Resilience And Mental Health Among Young Adults In The Context of Lockdown Due To The COVID-19 Pandemic
Authors: Guerrero-Vaca Darío , Carpio-Arias Valeria , Rodríguez-Betancourt Andrés , Ruiz Patricio Inca , Vinueza-Veloz Andrés Fernando , Loza-Chiriboga Juan Sebastián , Pérez-Haro Jéssica , Vinueza-Veloz María Fernanda
Published: December 2021

Purpose: Psychological resilience is defined as the ability of an individual to adapt to adverse situations and in a certain way regulate mental health. Currently, the COVID-19 pandemic and lockdown measures implemented to avoid infection are considered risk agents for the development of mental disorders. The objective of this study is to explore the relationship between resilience capacity and the presence of depressive symptoms and poor sleep quality in the context of lockdown due to the pandemic. Methods: The sample consisted of n = 8,426 young adults who were recruited via convenience sampling. Sociodemographic and mental health data was collected through online surveys. Previously validated test were used to collect information on depression and sleep quality. Restriction of mobility was evaluated using information from Google Mobility Reports. Results: Most of participants were highly educated women. Independently from sex, age and other confounders, individuals with psychological resilience were less likely to develop depressive symptoms or sleep disorders during confinement due to the COVID-19 pandemic. Moreover, higher mobility restriction was associated with depression but not with bad sleep quality. In this way, a longest stay at home and a higher restriction of mobility to groceries and pharmacies were related to depression. Conclusions: These results show evidence of the importance of psychological resilience on mental health, and can contribute to the development of preventive public health interventions to face the negative effects of confinement on mental health.
Silicon Binding in Soil Humic Substances
Authors: kar sanjib
Published: December 2021

In the present study, an attempt has been made to probe the nature of silicon-humus bonding as it occurs in nature ('untreated') as compared to the samples wherefrom the metalloid ions have been removed ('treated'). Infrared (IR) spectroscopy revealed the role of carboxylic acid groups of Humic acid (HA) in metal complexation. Si-O absorption reduced considerably in treatment to remove metalloid ions, but it remained quite strong in the treated samples indicating a strong Si-O linkage with humus. In XRD analysis, treated samples showed stronger γ-bands. DTA analysis indicated structural strain on the humic molecule induced by complexation with metalloid ions. Treated HAs had higher acidity values compared to the untreated samples. Treatment for removal of metal ions caused an increase in cation exchange capacity while a reduction of E4/E6 ratio. Treated HAs also showed higher molecular weights (Mv) compared to the untreated samples. Removal of metals renders certain groups free which form intermolecular bonds. On the basis of analytical data, it was observed that there is still some silicon bonds within humic acid molecule, even after removal of silicon by forcing conditions. Association of silicon with humus in soils are quantitatively and qualitatively different from other metal ions and it is clear that humic acid molecule possess silicon-humus bond like pure organo-metallic compounds.
ROSTMEMA: A Double-Blind Randomized Placebo-Controlled Trial with the PDE4 Inhibitor Roflumilast in Patients Suffering from Long-term Cognitive Sequela After Stroke
Authors: Kerckhoffs Jill , Blokland Arjan , Prickaerts Jos , Winkens Ieke
Published: December 2021

Background : The aim of this study is to examine whether treatment with roflumilast improves cognition in patients suffering from cognitive sequelae after stroke. The results may provide a proof of concept on the potential of roflumilast (or other phosphodiesterase-4 (PDE-4) inhibitors) as pharmacotherapeutic treatment to enhance cognition, and will further increase our knowledge on the role of PDE4 in human cognition in general. Cognitive processes, in particular memory, will be assessed. Methods : 100 female and male patients (41-70 years old) suffering from cognitive complaints 1 year after stroke will be recruited via advertisements via social media and via local caretaking organizations. The first phase of the study will be conducted according to a double-blind, randomized placebo-controlled, between-subjects design. After a baseline measurement, participants will be tested for acute (1 hour after drug intake) and subsequent chronic (1.5 and 3 months after start treatment) treatment effects. In a second phase, the placebo group (50 people) will be given the opportunity to receive roflumilast. This is an open label design. The roflumilast group will be tested for long-term treatment effects at three months after the end of treatment. Discussion : Strengths of the current study are the open-label design as well as the assessment of long-term effects. The findings of the current study will demonstrate if the mechanism of PDE4 inhibition is a relevant target to improve cognitive functions in patients with brain damage after a stroke. If positive effects are found in this patient group, this treatment could also be relevant for other brain disorders (e.g. head trauma, mild cognitive impairment, Fragile X syndrome, schizophrenia) in which enhanced neuronal plasticity is required to improve cognition. Trial registration : The Medical Ethics Committee of Maastricht University Medical Center+ granted ethics approval of the fourth version of the protocol on February 25, 2021. The trial was registered at the European Drug Regulatory Affairs Clinical Trials (EudraCT) register on July 29, 2020, https://www.clinicaltrialsregister.eu/ctr-search/search?query=2020-003768-16 and Clinicaltrials.gov (NCT04854811) at April 21, 2021, https://clinicaltrials.gov/ct2/show/NCT04854811. The Central Committee on Research Involving Human Subjects (CCMO) granted approval on May 4, 2021.
EFFICIENCY OF A MODIFIED CONICAL METALLIC COOKING STOVE INCORPORATING CLAY FOR OPTIMAL CHARCOAL CONSUMPTION IN KARA REGION - TOGO
Authors:   LaMERE, Faculty of Sciences and Technologies, University of Kara-Togo., Samah Hodo-Abalo , Kata Ndetigma ,   LaMERE, Faculty of Sciences and Technologies, University of Kara-Togo., Kpode Kodjo ,   LaMERE, Faculty of Sciences and Technologies, University of Kara-Togo.
Published: December 2021

An acceptability survey of improved charcoal stoves conducted in some households in the Kara region in Togo revealed that 40% of households use the clay cookestove and 30% the conical cookestove. Unfortunately the configuration of the clay stove requires permanent maintenance. To combine the advantages of the two both types of stoves widely used, a modified conical cookestove model integrating clay with an optimized thickness of 4 centimeters is proposed and tested. The procedure used is similar to that proposed by a group of experts for the Household Energy and Health Program of the Shell Foundation. The results showed that thermal efficiency of modified conical cookestove is improved about 17.35% relatively to conical cooking stove but compared to the clay cookestove, the improvement about 5.18% only is reported. The specific consumption of the modified conical stove save 2.76% of charcoal relatively to conical cookestove while over consumption of 2.62% is reported relatively to the clay cooking stove. The study found that the modified conical cookestove offer an alternative to replace the clay cooking stove and can solve the problem of maintenance and durability. Modified conical cookestove or clay cookestove is suitable for long cooking while the conical cooking stove is better for short cooking.
STRUCTURAL SOCIAL CAPITAL OF PARENTS HAVING PERSONS WITH DISABILITY IN CHANDIGARH
Authors:   Research Scholar, Department: Department of Community Education and Disability Studies, Panjab University, Chandigarh, India., Jindal Parineeta , Sharma Anuradha ,   Professor, Department of Community Education and Disability Studies, Panjab University, Chandigarh, India.
Published: December 2021

Structural social capital is understood as maintenance of connections, immense trust, following of certain rules and fulfilling certain commitments. It is pertinent to improve quality of life. The present research aimed to study the structural social capital of parents having persons with disability living in Chandigarh. The descriptive survey method with convenient sampling technique was employed. Twenty-five parents of persons with disability (N=25) having age group 20 to 55 years were in the sample. The questionnaire comprised of six statements and each statement had sub-items with the options of yes and no. Results showed that parents having persons with disabilities hadgood network ties with relatives, neighbours and friends but a few parents having persons with disabilities did not have good bondings. Besides, majority did not participate in the activities such as social and cultural clubs, religious organisation, government schemes, local community function and political organisation.The authors recommend that support from government, non-government organisation and community to provide financial, moral and psychologicalhelp to families of PWD is important for healthy development of all individuals of society.
CONSELHO DO FUNDEB NO DF: MISSÃO QUASE IMPOSSÍVEL!
Authors: Da Silva Francisco José
Published: December 2021

o objetivo desse artigo é discutir as limitações do Conselho do Fundeb do Distrito Federal para realizar o acompanhamento e controle social dos recursos financeiros do Fundo, do Programa Nacional de Apoio ao Transporte Escolar e do Plano de Ações Articuladas. Utilizou-se principalmente legislação referente às atribuições do Conselho e documentos produzidos por ele. O estudo indica a necessidade do Conselho concentrar as suas ações no acompanhamento e controle social, e não na fiscalização, uma vez que esta é de competência dos órgãos de fiscalização.
Propagation dynamics and causes of hydrological drought in response to meteorological drought at seasonal timescales
Authors: Ma Lan , Huang Qiang , Huang Shengzhi , Liu Dengfeng , Leng Guoyong , Wang Lu , Li Pei
Published: December 2021

According to the widely accepted definition of drought, meteorological and hydrological droughts originally develop from rainfall and runoff deficits, respectively. Runoff deficit is mainly derived from rainfall deficit, and the propagation from meteorological drought to hydrological drought is critical for agricultural water management. Nevertheless, the characteristics and dynamics of drought propagation in the spatiotemporal scale remain unresolved. To this end, the characteristics and dynamics of drought propagation in different seasons and their linkages with key forcing factors are evaluated. In this study, meteorological and hydrological droughts are characterized by the Standardized Precipitation Index (SPI) and the Standardized Runoff Index (SRI), respectively. Propagation time is identified by the corresponding timescale of the maximum correlation coefficient between the SPI and the SRI. Then, a 20-year sliding window is adopted to explore the propagation dynamic in various seasons. Furthermore, the multiple linear regression model is established to quantitatively explore the influence of meteorological factors, underlying surface features and teleconnection factors on the propagation time variations. The Wei River Basin, a typical Loess Plateau watershed in China, is selected as a case study. Results indicate the following: (1) the propagation time from meteorological to hydrological drought is shorter in summer (2 months) and autumn (3 months), whereas it is longer in spring (8 months) and winter (13 months). Moreover, the propagation rates exhibit a decreasing trend in warm seasons, which, however, show an increasing trend in cold seasons; (2) a significant slowing propagation in autumn is mainly caused by the decreasing soil moisture and precipitation, whereas the non-significant tendency in summer is generally induced by the offset between insignificant increasing precipitation and significant decreasing soil moisture; (3) the replenishment from streamflow to groundwater in advance prompts the faster propagation from meteorological to hydrological drought in spring and winter and (4) teleconnection factors have strong influences on the propagation in autumn, in which Arctic Oscillation, El Niño-Southern Oscillation and Pacific Decadal Oscillation mainly affect participation, arid index and soil moisture, thereby impacting drought propagation.
Analysis of spatiotemporal variations of drought and its correlations with remote sensing-based indices via wavelet analysis and clustering methods
Authors: Ghasempour Roghayeh , Roushangar Kiyoumars , Ozgur Kirca V. S. , Demirel Mehmet Cüneyd
Published: December 2021

Beside in situ observations, satellite-based products can provide an ideal data source for spatiotemporal monitoring of drought. In this study, the spatiotemporal pattern of drought was investigated for the northwest part of Iran using ground- and satellite-based datasets. First, the Standardized Precipitation Index series were calculated via precipitation data of 29 sites located in the selected area and the CPC Merged Analysis of Precipitation satellite. The Maximal Overlap Discrete Wavelet Transform (MODWT) was used for obtaining the temporal features of time series, and further decomposition was performed using Ensemble Empirical Mode Decomposition (EEMD) to have more stationary time series. Then, multiscale zoning was done based on subseries energy values via two clustering methods, namely the self-organizing map and K-means. The results showed that the MODWT–EEMD–K-means method successfully identified homogenous drought areas. On the other hand, correlation between the satellite sensor data (i.e. the Normalized Difference Vegetation Index, the Vegetation Condition Index, the Vegetation Healthy Index, and the Temperature Condition Index) was evaluated. The possible links between central stations of clusters and satellite-based indices were assessed via the wavelet coherence method. The results revealed that all applied satellite-based indices had significant statistical correlations with the ground-based drought index within a certain period.
Circulation type analysis of regional hydrology: the added value in using CMIP6 over CMIP5 simulations as exemplified from the MPI-ESM-LR model
Authors: Ibebuchi Chibuike Chiedozie
Published: December 2021

This study addresses the applicability of general circulation models (GCMs) in studying the impact of climate change on hydrology. The statistical downscaling of precipitation based on circulation types (CTs) derived from the fuzzy, i.e., more than one CTs can occur in a given day, obliquely rotated principal component analysis is suggested as a robust methodology in using climate models to research the impact of climate change on hydrology. The methodology allows understanding of the mechanism of atmospheric circulation in the study region, and the physical relationship between atmospheric circulation and the regional hydrological cycle. The capability of climate simulations from the Max Planck Institute Earth System Model (MPI-ESM) GCM to reproduce the observed CTs in the target region is examined in light of the uncertainty of atmospheric GCMs when used for circulation typing. The results were discussed and it showed that, generally, the analyzed GCM can reproduce the underlying physics of atmospheric circulation in the study region, represented by the CTs, together with their dominant periods, probability of occurrence, and annual frequency of occurrence with modest biases. Generally, the Coupled Model Intercomparison Project 6 (CMIP6) simulation indicates some improvement for the CT-based analysis relative to the CMIP5 counterpart; however, this depends on the analyzed CT.
Monitoring of cyanobacteria using derivative spectrophotometry and improvement of the method detection limit by changing pathlength
Authors: Malhotra Amitesh , Örmeci Banu
Published: December 2021

Effective monitoring tools and methods are needed for the early detection and management of cyanobacteria in water bodies to minimize their harmful impacts on the environment and public health. This research investigated changing the cuvette pathlength (10-, 50-, and 100-mm) to improve the detection of cyanobacteria using UV-Vis spectrophotometry with subsequent application of derivative spectrophotometry and Savitzky-Golay (S-G) transformation. A non-toxigenic strain of blue-green cyanobacteria, Microcystis aeruginosa (CPCC 632), and a green algae strain for comparison, Chlorella vulgaris (CPCC 90), were studied in a wide range of concentrations (955,000 to 1855 cells/mL). In each concentration range, method detection limits were established with absorbance measurements and S-G first derivative of absorbance using 10-, 50-, and 100-mm cuvette pathlengths. Increasing the cuvette pathlength from 10 to 100 mm resulted in a 15-fold improvement in sensitivity with absorbance and a 13-fold improvement with S-G first derivative of absorbance for M. aeruginosa. Overall, adoption of 100 mm pathlength and application of S-G derivative spectra improved the method detection limit for M. aeruginosa from 337,398 to 4916 cells/mL, which is below the WHO guideline for low probability of adverse health effects (<20,000 cells/mL). Similarly, the detection limit for C. vulgaris was improved from 650,414 to 11,661 cells/mL. The results also showed that spectrophotometry could differentiate M. aeruginosa from C. vulgaris based on the variations in their pigment absorbance peaks.
Membrane cleaning in membrane distillation of reverse osmosis concentrate generated in landfill leachate treatment
Authors: Jia Xiaolin , Li Kuiling , Wang Baoqiang , Zhao ZhiChao , Hou Deyin , Wang Jun
Published: December 2021

As a thermally induced membrane separation process, membrane distillation (MD) has drawn more and more attention to the advantages of treating hypersaline wastewaters, especially the concentrate from the reverse osmosis (RO) process. One of the major obstacles in widespread MD application is the membrane fouling. We investigated the feasibility of direct contact membrane distillation (DCMD) for landfill leachate reverse osmosis concentrate (LFLRO) brine treatment and systematically assessed the efficiency of chemical cleaning for DCMD after processing LFLRO brine. The results showed that 80% water recovery rate was achieved when processing the LFLRO brine by DCMD, but membrane fouling occurred during the DCMD process, and manifested as the decreasing of permeate flux and the increasing of permeate conductivity. Analysis revealed that the serious flux reduction was primarily caused by the fouling layer, which consisted of organic matter and inorganic salts. Five cleaning methods were investigated for membrane cleaning, including hydrogen chloride (HCl)-sodium hydroxide (NaOH), ethylene diamine tetraacetic acid (EDTA)-NaOH, citric acid, sodium hypochlorite (NaClO) and sodium dodecyl sulphate (SDS) cleaning. Among the chemical cleaning methods investigated, the 3 wt.% SDS cleaning showed the best efficiency at recovering the performance of fouled membranes.
Intratrynitarność Boga jako objawiony klucz hermeneutyczny chrześcijańsko-prawdziwościowej antropologii
Authors: Płóciennik Michał
Published: December 2021

Trójjedyność Boga jest treścią najważniejszego chrześcijańskiego dogmatu, będąc kluczem hermeneutycznym doświadczenia Objawienia i historii zbawienia. Stanowi ona jedną i w gruncie rzeczy jedyną Prawdę wielu prawd wiary. Doświadczeniem, które konstytuuje chrześcijaństwo, jest bowiem radykalne i definitywne samoudzielenie się trójjedynego Boga – Pater per Filium in Spiritu Sancto. Dlatego zrozumienie, kim jest trójjedyny Bóg, stanowi niezbywalny chrześcijańsko-prawdziwościowy warunek wszelkiej możliwej hermeneutyki. Nie chodzi tu jedynie o fascynującą spekulację, ale o być albo nie być chrześcijaństwa, a tym samym o być albo nie być ludzkości w jej całej stworzonej realności jako właściwego adresata samoudzielenia się Boga. Tajemnica każdego człowieka, zarówno w jego wymiarze indywidualnym jak i społecznym, jest bowiem z chrześcijańskiej perspektywy dana do rozumienia jedynie jako wydarzająca się pomiędzy Ojcem, Synem i Duchem Świętym.
Chrześcijańska osada Qusur na wyspie Fajlaka (Kuwejt)
Authors: Żurek Magdalena
Published: December 2021

Chrześcijańska osada Qusur na Fajlace istniała w centrum wyspy w VII-VIII w., choć możliwe, że pierwsi osadnicy mogli pojawić się wcześniej. Jej opuszczenie związane jest z powstaniem islamskiej wsi na wybrzeżu. Qusur jest największą i najlepiej rozpoznaną osadą chrześcijańską w rejonie Zatoki Perskiej. Na jej obszarze zidentyfikowano ok. 90 domów i kościół oraz budowlę publiczną o nieustalonym przeznaczeniu. Osada posiada zwartą zabudowę w centrum, skupioną wokół kościoła i wspomnianej budowli, na peryferiach odległości między domami zwiększają się. Małe domy złożone z kilku pomieszczeń, często o tynkowanych ścianach i podłogach z  wylewki wapiennej, otoczone były rozległymi dziedzińcami.
Wartości emancypacyjne i obywatelsko – narodowe w wychowaniu skautowym dziewcząt na ziemiach polskich do 1921 roku
Authors: Głowacka Sobiech Edyta
Published: December 2021

Celem artykułu jest opisanie procesu emancypacji w skautingu oraz edukacji obywatelskiej w wychowaniu skautowym dziewcząt/kobiet/skautek na ziemiach polskich do 1921 roku. Rok 1921 jest kluczowy, bo zamyka kwestię wywalczenia przez kobiety w Polsce części praw (prawa wyborcze) oraz prostuje sprawy narodowe – Polska odzyskuje niepodległość i kończą się walki o jej granice, jednoczy się harcerstwo. W artykule pokazano, jaką rolę w życiu skautek odegrały ścieżka samodzielności i emancypowania, a przede wszystkim edukacja obywatelska i wychowanie skautowe. Tekst odpowiada na pytanie, na ile imperatyw „mówić i działać” odzwierciedlający kompetencje emancypacyjne i obywatelskie znajduje odzwierciedlenie w historii skautingu żeńskiego na ziemiach polskich (do 1921 roku).
Teoria dos campos conceituais como instrumento para o planejamento e construção de recursos tecnológicos para o ensino de ciências
Authors: Nicolete Priscila Cadorin , Santos Aline Coelho dos , Tarouco Liane Margarida Rockenbach , Silva Marta Adriana Machado da
Published: December 2021

Este trabalho apresenta a Teoria dos Campos Conceituais de Vergnaud como instrumento para o planejamento e construção de recursos tecnológicos para práticas pedagógicas. O estudo tem como objetivo investigar de que maneira um aplicativo móvel, à luz da teoria de Vergnaud, pode contribuir para o ensino de conceitos referentes ao Princípio de Arquimedes para alunos do 9º ano do ensino fundamental. A pesquisa foi realizada com 78 estudantes de uma escola pública e teve uma abordagem quantitativa e qualitativa, com procedimento de um estudo de caso. O estudo demonstra o potencial da teoria de Vergnaud como referencial teórico para o planejamento didático e na construção de recursos tecnológicos que envolvam ativamente os estudantes nos processos de ensino e aprendizagem, pois auxilia no desenho de situações de ensino, na seleção dos conceitos e teoremas-chave e suas relações.
Cursos de formação de profissionais de educação mal avaliados e impactos no desempenho estudantil em testes de larga escala
Authors: Gama Zacarias Jaegger
Published: December 2021

Afirmando haver relação entre a qualidade da formação dos profissionais de educação e o desempenho de estudantes de 15 anos em testes internacionais de larga escala, a investigação tomou como ferramenta de busca os cursos de Matemática, Biologia e Pedagogia/Letras existentes no Brasil avaliados pelo RUF 2019 – Ranking Universitário Folha e os dados do relatório do PISA (Programa Internacional de Avaliação de Estudantes) a fim de comprová-la. Também se observou que as normas legais que deveriam orientar o perfil do profissional de educação e a estruturação curricular dos cursos de formação têm sido erráticas, dificultando que se consolidem e possam ser avaliados. Ao comparar os cursos existentes com a amostra construída pelo PISA para a aplicação dos testes, foi percebida a simetria entre profissionais de educação egressos de cursos mal avaliados e baixos desempenhos dos estudantes, assim como a necessidade de políticas garantidoras da qualidade dos cursos de formação, uma condição para diminuir as desigualdades regionais características da sociedade brasileira.
Compromisso educacional e social: trajetórias de professores que desenvolvem projetos sociais esportivos
Authors: Godoi Marcos Roberto , Kawashima Larissa Beraldo , Moreira Evando Carlos
Published: December 2021

O esporte tem sido utilizado como um recurso educacional em projetos sociais. Neste sentido, o objetivo desta pesquisa foi descrever e analisar as trajetórias formativa e profissional dos professores que desenvolvem esse tipo de projetos. Este é um estudo descritivo e multicasos, baseado nas histórias de vida. A pesquisa foi realizada com três professores de Educação Física que desenvolvem projetos sociais com capoeira, voleibol e capoeira. O esporte, a educação familiar e escolar e o meio social onde cresceram marcaram a formação pré-profissional dos docentes. Dois deles fizeram estágios em projetos esportivos e um professor buscou novos conhecimentos para atuar. Dois professores estão na fase de diversificação da carreira e o professor mais experiente está na fase de renovação do interesse pela profissão. Além da formação técnica e dos resultados em competições ou eventos esportivos, os professores têm um forte compromisso educacional e social com seus alunos e comunidades atendidas. O estudo aponta para a necessidade de se investir na captação de recursos para os projetos e de politicas públicas que incentivem projetos desenvolvidos por iniciativa de professores.
Diversidade e diferença: representações sociais no espaço educacional
Authors: Souza Sandra Cristina Morais , Perez Carmem Lúcia Vidal
Published: December 2021

Este artigo é uma revisão narrativa, e seu objetivo foi identificar o panorama da produção acadêmica nacional pertinente aos temas diversidade e diferença na perspectiva da Teoria das Representações Sociais no campo da Educação. A literatura acadêmica e a científica têm publicado diversos estudos que investigam esses fenômenos sociais. Nessa direção, procuramos aprofundar a temática realizando pesquisas nas bases de artigos e periódicos indexados, como o Portal de Periódicos da CAPES e SCIELO, relativos aos anos de 2010 a 2018. No decorrer do texto, depois de feita a análise descritiva dos trabalhos, procedeu-se a uma interpretação qualitativa dos trabalhos. Os resultados indicaram que o número de estudos que tratam da diversidade e da diferença no espaço educacional é incipiente e, quando se apresentam, são atravessados pelo fenômeno da inclusão de pessoas com deficiência ou abordam a questão da diversidade sexual e racial. Nesse sentido, a diversidade e a diferença não atendem a todos, pois só incluem determinadas categorias e deixam de fora as demais. Foi possível perceber que esses temas ainda são delicados no contexto da Educação. A questão da diversidade e da diferença na educação sugere uma discussão acerca dos vários processos de exclusão social e a participação da escola nesses processos.
Amorosidade, autopoiese e ‘com-versações’: a potência dos ‘entrelaços nós’ na educação e na ciência
Authors: Baptista Maria Luiza Cardinale
Published: December 2021

O texto tem caráter ensaístico, abordando a potência da amorosidade, da autopoiese e das ‘com-versações’, no acionamento dos ‘entrelaços nós’ na Educação e na Ciência. Traz o relato de reflexões, resultantes de percursos de aprendizagem direta com Humberto Maturana, em conexão com formação holística e esquizoanalítica. O ensaio fundamenta-se em produção científica de mais de 30 anos, em pesquisas, supervisões de escrita de teses, dissertações e monografias, em muitos universos de saberes, e orientações diretas de investigadores no Sul do Brasil, em Comunicação, Turismo e Hospitalidade. Relata emergências, urgências e potencialidades, expressas nas conversas e pesquisas do Amorcomtur! Grupo de Estudos em Comunicação, Turismo, Amorosidade e Autopoiese, que se acirram com as demandas para o mundo Pós-Pandemia Covid-19. Entre elas, está a urgência de uma ‘re-evolução’ amorosa, em termos reflexivos e de produção, em que os ‘nós’ – as conexões intensas e afetivas de seres e ecossistemas – sejam reconhecidos como a grande potência de reinvenção e como chance de sobrevivência da Educação, da Ciência e do Planeta.
The Potency of Wound Healing of Nanogel-containing Mikania micrantha
Leaves Extract in Hyperglycemic Rats
Authors: Sumantri Imam Bagus , Ismayadi  , Mustanti Lolyta Fitri
Published: December 2021

Introduction:

Mikania micrantha has been traditionally used for wound dressings and
to promote the healing of sores. This is due to the content of alkaloids and terpenoids/steroids compounds.
Hyperglycemia is a good medium for bacterial growth that inhibits the wound healing process.

Purpose:

This study aimed to determine the wound healing of nanogels containing MMLE in hyperglycemic
rats as a model for diabetic wounds.

Methods:

Mikania micrantha leaves were extracted with the maceration method using 96% ethanol
in 5 days. Carbopol 940 was used as the gelling agent. The parameters observed during the physical
testing of nanogels were organoleptic, homogeneity, pH, and size of the particle. Antibacterial
activity was tested on Staphylococcus aureus, Staphylococcus epidermis, and Escherichia coli.
Moreover, wound healing activity was tested in hyperglycemic rats after observing for 14 days. Diabetic
wound healing was treated with 4 groups (P1, P2, K1, K2). Data were analyzed using SPSS.

Results:

Nanogel showed homogeneity, dark green color, transparency, pH 6.1± 0.1, and particle
size range in 255-456 nm. The inhibition zones of antibacterial testing, i.e., Staphylococcus aureus,
Staphylococcus epidermis, and Escherichia coli, were 10.57 ± 0.26 mm, 9.73 ± 0.21 mm, and 8.4 ±
0.1 mm. The percentage of diabetic wound healing was in the range of 92.79±3.81% to 94.08 ±
2.33% for 14 days of observation.

Conclusion:

MMLE nanogels have the potential as a treatment for diabetic wound healing.
Forensic Psychiatry and Psychopathology: An Amendment in Contemporary
Period
Authors: Shafti Saeed Shoja
Published: December 2021

As stated by Jaspers, a delusion is a deviant assessment of reality that
is irredeemably believed. Therefore, while the delusions are apprehended with
the uncommon verdict and are not open to rationality, their irrationality or wrongness
is obvious to other persons. While Norman Cameron’s pseudo-community,
a supposed community of conspirators, was a historical description of conditions
that promote the development of delusional disorders, modern technology and advancement
of new communicative tools, like smartphone, hidden camera, satellite,
internet, and stealthy or scheming tricks or setups, like double-crossing and
masquerading scenarios, stressful circumstances, furtive or hectic arrangements,
creating a scene to deceive, hack, or tampering, have brought about the possibility
of a conspiracy by prejudiced or inimical people, which may amplify the conceivable
diagnostic faults by the perplexity of circumstances. On the other hand,
it is the duty of forensic and clinical psychiatrists to guess or discover any kind
of deceptive entrapment or simulation. In the present article, the said eccentricities,
which may have been accelerated by modern technology, have been discussed
briefly, especially with respect to paranoia and paranoid ideation. Moreover,
some clarifications for better demarcation of the discussed problem and
modification of operational definitions in the realm of psychopathology have
been suggested. Certainly, ample watchfulness by a clinical or forensic psychiatrist
for neutralizing a thinkable intrigue is an apposite performance for improving
civil rights and preventing preventable slips.
SOCIAL MEDIA, PUBLIC SPHERE AND THE POLITICAL TRAGEDIES OF CONTEMPORARY ETHIOPIA
Authors: ADERA Binyam Mekonnen
Published: December 2021

Ethiopia since 1991 G.C has been adopting democracy and federalism as constitutional frameworks of the state. The core objective to maintain the two political cultures is the presence of multiple cultural identities within the state and the actual need for an intersubjective discussion on the public sphere. And one of the major areas of public sphere is the social media. As per the Constitution of the Federal Democratic Republic of Ethiopia citizens of Ethiopia have the democratic rights of Thoughts, Opinion and Expression (Art. 29), so in social media it is natural to expect that individuals talk on the different affairs of the state ‘freely’. Basically the social media is serving as an instrument in maintaining discursive talk among individuals. However, it has been also producing considerable social turmoil across the world. The same is what is encountering in Ethiopia today; on the one hand, social media as a communication platform allows people to communicate effectively with sharing alternative views, attitudes and forming democratic consensus on the social anomalies and responses, and on the other hand, the media is the sphere of communicative maladjustment where misunderstanding, extremism and miscommunication is producing. In the present Ethiopian context the basic source of communication and miscommunication in the social media is the ‘pluriversal identities’ of the cultural horizon. Taking this as a crucial object, this article will discuss the connection between democracy, federalism and social media in the current Ethiopia. On the top of this, the study aims at exploring the following issues: the social media sphere in Ethiopia, the modern and postmodern challenges of social media in Ethiopia and alternatives for the social media reconstruction.
SOCIAL DIMENSION OF INNOVATION RESEARCH IN THE CONDITIONS OF SOCIAL TRANSFORMATIONS
Authors: YERESKOVA Tetyana , MAZURYK Oleg
Published: December 2021

The article is devoted to understanding the social dimension of perception of innovations, which allows to determine the vector of perception of transformational changes in society. The urgency of the problem is due to the multicomponent processes of social transformations and the polyvariety of their consequences for social development. The theoretical foundations of scientific research are based on the analysis of theories of social transformations, stages of the “innovation life cycle”, typology of subjects of perception of innovations existing in the socio-humanitarian discourse. The article substantiates the expediency of taking into account the methodological aspects of the study of innovation as a social process through the emphasis on the impact of social well-being of members of society on the perception of innovative changes as a result of socio-economic, political, cultural transformations. A classification of innovations is proposed, depending on their perception by members of society (“recognized innovations”, “fragmentary innovations”, “marginal innovations”, “antagonistic innovations”, “rejected innovations”). The possibilities of their empirical classification were tested based on the results of the secondary analysis of the data of the annual monitoring “Ukrainian Society: Monitoring Social Changes” (Institute of Sociology of the National Academy of Sciences of Ukraine). As a result of the research it was possible to determine the basic indicators of perception of social reality by members of Ukrainian society in periods of social transformations (“satisfaction with one’s position in the period of social transformations”, “ability to live in new social conditions”, “satisfaction with one’s own life”); to trace their dynamics in the periods defined in the article by the authors as stages of social transformations (1994, 2004, 2014, 2020). According to the authors, it is during these periods that certain socio-cultural changes, which determine the vital activity of Ukrainian society, have been initiated. It is concluded that indicators of social well-being of members of society should be analyzed and taken into account when planning innovations, because it allows to predict and consider potential social reactions not only to the emergence of innovations introduced as part of social transformation, but also their level of social support in conditions of social transformations.