bluuebunny/crossref_metadata_2025 huggingface dataset:
Predicting The Toxicity of Emerging Pollutants via Molecular Docking: Interaction of Polyhalogenated Carbazoles with Human Androgen Receptor
Authors: Armas Ma. Juryst Chelsea , Apodaca Dahlia
Published: November 2022

Polyhalogenated carbazoles (PHCZs) are persistent chemical pollutants increasingly detected in different environmental matrices. They are structurally and chemically similar to other persistent organic pollutants (POPs), which are capable of disrupting the endocrine systems. However, PHCZs such as 3-chloro-9H-carbazole (3-CCZ), 3-bromo-9H-carbazole (3-BCZ), and 36-dibromo-9H-carbazole (36-BCZ) are rarely discussed in the context of their adverse effects on human health. Using molecular docking to investigate the potential toxicity of these PHCZs with the human androgen receptor (AR), this study finds that 36-dibromo-9H-carbazole and 3-bromo-9H-carbazole are potential AR antagonists, with the former being more toxic than the latter. This finding is on account of the presence of both Asn705 and Thr877 in the hydrophobic interaction of 36-BCZ, while only Thr877 is found in the hydrophobic interaction of 3-BCZ. Hence, PHCZs with higher bromine substitutions are more likely to be endocrine disruptors. Moreover, their binding sites with the human androgen receptor are similar to that of the androgen (agonist). Therefore, this study suggests that PHCZs may readily penetrate and disrupt the human androgen receptor (AR), providing the groundwork for future research studies and experimental validation on the molecular docking employed.
Peculiarities of the business environment’s natural honey producer on the ukrainian consumer market
Authors: Starostina Alla , Bilovodska Olena , Shkiria Anastasiia
Published: November 2022

In today’s world, the business environment’s study of natural honey producers in the Ukrainian market needs special attention, because in conditions of excess supply over demand, increased competition among domestic producers significantly complicate sales. Askania-Pak Company is one of the largest exporters of honey in Ukraine. That is why the subject of the article is the business environment of honey producers in the Ukrainian consumer market. The purpose of the article is to determine the peculiarities of the business environment of Ukrainian natural honey producer on the basis of the analysis of micro- and macro environment of Ascania-Pack Company in the consumer market. General scientific methods ar used, such as system analysis, synthesis, abstract-logical and scientific abstraction – to find out basic factors of macromarketing environment that influence activity of Ascania-Pack Company; to single out the most essential of all possible factors; induction and deduction were used from discovery of general factors in terms of macromarketing environment analysis to formation of alternative variants of managerial problem solution. The following results were obtained: peculiarities of business environment of natural honey producer on the basis of micro- and macro environment analysis of Ascania-Pack Company activity in the consumer market were determined. Conclusions: the selection of factors for groups of macromarketing environment (political and legal, economic, demographic, scientific and technical, natural and climatic and cultural) was made; the marketing threats and opportunities for the activity of Ascania-Pack Company were singled out; the alternative variants of solution of a management problem of preservation and expansion of the existing market share of Ukrainian honey for strengthening of competitive position of the company were developed.
International experience and current trends in the development of the gastronomy tourism market of the European region in the conditions of COVID-19
Authors: Zhylenko Kateryna , Dolhiier Alisa
Published: November 2022

The sphere of tourism business is one of the most powerful and promising sectors of the national economy of the world. Today the modern alternative destination is gaining popularity - gastronomic tourism, which is a specialized type of tourism and includes acquaintance with the national culinary traditions of the world, as well as tasting of food and beverages, which is a synthesis of ecology, culture and production. The subject of research in the scientific article is the current international trends in the development of the gastronomic tourism market of the European region. The aim of the article is to assess the international trends in the development of the gastronomic tourism market and identify key trends for improving the gastronomic tourism market in the current conditions of COVID-19. In this scientific work the following research methods are used: descriptive, historical-geographical, comparative, statistical, systematization and generalization, terminological analysis, analytical, cartographic. The results of research on this topic can be used in the field of restaurant and hotel business and tourism as ideas for the development and increase of competitive advantages in business, as well as presented for discussion at seminars and conferences in this field. Conclusions: the study of current international trends and innovative trends in the market of gastronomic tourism in the European region allowed to identify key areas and key trends in the functioning, improvement and further promotion of gastronomy as an alternative direction of tourism in the current environment.
Deteksi Dini Melalui Pemeriksaan Sputum Pada Anggota Keluarga dan Pemeriksaan Rumah Penderita Tuberkulosis
Authors: Aminah Siti , Sulistianingsih Eka , Hasan Amrul , Kadarusman Haris
Published: November 2022

Pengabdian masyarakat Program Kemitraan Wilayah dilaksanakan di kecamatan Panjang terdiri dari 8 kelurahan, merupakan wilayah kerja puskesmas Panjang kota Bandar Lampung. Rencana Pembangunan Jangka Menengah (RPJMD) kecamatan Panjang tahun 2015-2019 tantangan utamanya adalah pelaksanaan wajib belajar, sarana dan prasarana sekolah, rendahnya kualitas kesehatan penduduk, tingginya angka penemuan kasus  penyakit menular. Puskesmas Panjang dengan temuan kasus tertinggi dari 30 puskesmas  kota Bandar Lampung, dengan CDR ( case detection rate) 491, jumlah penemuan kasus 110 orang dengan cakupan penemuan kasus tuberkulosis 22%, (Dinkes kota Bandar Lampung,2018). rendahnya cakupan rumah sehat mencapai 64,2%. Tingkat penularan penderita Tuberkulosis 65% (Pedoman nasional pengendalian Tuberkulosis, 2014) Anggota keluarga penderita Tuberkulosis, memiliki risiko tinggi untuk tertular penyakit Tuberkulosis. Dilakukan pengabdian masyarakat dalam bentuk pelatihan kader posyandu, pengambilan dan pemeriksaan dahak/sputum mikroskopis pada anggota keluarga penderita Tuberkulosis, pemeriksaan rumah penderita, penyuluhan kepada keluarga penderita, tentang penyakit Tuberkulosis, cara penularan dan cara pencegahannya, rumah yang memenuhi syarat kesehatan. Hasil pemeriksaan sputum berjumlah 109, 100 % negatif (-). Hasil pemeriksaan rumah yang diperiksa 44, Memenuhi syarat dan tidak memenuhi syarat ketersediaan air bersih 72,7% dan 27,3%, tempat pembuangan sampah 72,7% dan 27,3%, ukuran ventilasi rumah 51,2% dan 48,8%, kelembaban udara rumah 84,1% dan 15,9%, lantai rumah 100% dan 0% ketersediaan jamban 97,7% dan 2,27%. Kesimpulan tidak ditemukan penderita Tuberkulosis baru dari keluarga penderita.
Pelatihan Teknik Mengurangi Nyeri Persalinan Kala I Dengan Massage Effleurage Pada Bidan di Wilayah Kerja Puskesmas Tanjung Bintang Lampung Selatan Tahun 2019
Authors: Imron Riyanti , Risneni Risneni , Aziza Nyimas
Published: November 2022

Nyeri persalinan adalah manifestasi dari adanya kontraksi (pemendekan) otot rahim. Kontraksi ini menimbulkan rasa sakit pada pinggang, daerah perut dan menjalar kearah paha. Berdasarkan hasil penelitian sebagian besar (90%) persalinan disertai rasa nyeri dan 7-14% saat bersalin tanpa rasa nyeri (Prawirohardjo,2007). Hasil presurvey pada bulan April 2019 di Praktek Mandiri Bidan (PMB) Kabupaten Lampung Selatan didapatkan data tahun 2018 dengan jumlah persalinan 360 orang/tahun, dan rata–rata  30 orang/bulan. Hasil wawancara bebas dari 10 orang ibu postpartum di  PMB, 7 orang (70%) mengatakan  merasakan nyeri sekali saat menjelang persalinan dan 3 orang (30%) mengatakan tidak terlalu nyeri saat ada kontraksi. Berdasarkan wawancara, ibu post partum tersebut mengatakan sampai saat ini belum pernah di ajarkan teknik untuk menghilangkan rasa nyeri atau teknik relaksasi dengan massage effleurage. Berdasarkan survey terhadap bidan di wilayah kerja Puskesmas Tanjung Bintang Lampung Selatan 80% bidan belum mengetahui bahwa perlakuan massage effleurage dan abdominal lifting dapat mengurangi nyeri persalinan Kala I. Tujuan pelaksanaan Kegiatan pelatihan Tekhnik Pengurangan Nyeri Persalinan kala I adalah mengajarkan teknik mengurangi rasa nyeri pada ibu bersalin kala I kepada bidan di wilayah kerja Puskesmas Tanjung Bintang agar ibu bersalin di wilayah kerja Puskesmas Tanjung bintang dapat bersalin dengan nyaman tanpa merasakan nyeri pada persalinan. Berdasarkan fenomena di atas, maka tim pengabmas tertarik melakukan  Pelatihan Tekhnik Pengurangan Nyeri Persalinan Kala I dengan Massage Effleurage Pada Bidan Di Wilayah kerja Puskesmas Tanjung Bintang Lampung Selatan  Tahun 2019. Kegiatan pelatihan Tekhnik Pengurangan Nyeri Persalinan kala I ini dengan memberikan materi menggunakan  metode ceramah, diskusi, tanya jawab dan pratikum dengan menonton audio visual serta demonstrasi. Alat bantu yang di gunakan adalah: lembar balik, LCD, Laptop, Film, sound system, untuk pratikum massage Efflurage dengan phantom ibu hamil, selimut, baby oil, handuk, buku dan pulpen. Sebelum pelatihan semua peserta di berikan pre-test dan sesudah pelatihan di lakukan post test. Sebelum  pemberian materi,  13 % pengetahuan bidan baik, 70% cukup dan 17% kurang. Setelah  pemberian materi rata-rata pengetahuan  peserta/bidan  meningkat menjadi 90% baik, 10% cukup. Untuk pratikum dalam melakukan massage Efflurage pada ibu inpartu kala 1 dalam mengurangi nyeri di dapatkan 100%  bidan dapat melakanakan dengan baik
Pelatihan Kewirausahaan Pembuatan Sabun Cuci Piring Lunak Berbahan Baku Minyak Jelantah Kepada Kelompok Karya Ilmiah Remaja SMPN 27 Kabupaten Pesawaran Tahun 2020
Authors: Djayasinga Rodhiansyah , Nursindam Nursindam , Fitriany Khairuni , Sulistianingsih Eka , Sugiarti Mimi , Nurminha Nurminha , Dinutanayo Wimba Widagdho
Published: November 2022

Untuk menumbuhkan jiwa kewirausahaan bagi para Siswa siswi SMPN 27 Kabupaten Pesawaran maka melalui Program Kegiatan Pengabdian Masyarakat Skema Mandiri oleh Tim Dosen Pengabdian Polkes Tanjungkarang Jurusan Analis Kesehatan, dipandang perlu melaksanakan pelatihan kewirausahaan dengan memanfaatkan limbah minyak jelantah menjadi sabun cuci piring lunak kepada siswa siswi SMPN 27 Kabupaten Pesawaran. Analisis Situasi, Berdasarkan data Profile Tahun 2020, SMPN 27 Kabupaten Pesawaran memiliki rombongan belajar kelas VII sejumlah 3 kelas dengan jumlah siswa 83 siswa,   rombongan belajar kelas VIII sejumlah 3 kelas dengan jumlah siswa 75 siswa.  Permasalahan Mitra, KIR SMPN 27 Kabupaten Pesawaran belum pernah mendapatkan pembinaan kewirausahaan,. belum memiliki pengetahuan dan keterampilan tentang teknik pembuatan sabun berbahan baku minyak jelantah yang memiliki potensi untuk dikembangkan menjadi suatu bentuk wirausaha.  Solusi yang diberikan oleh Tim Pengabmas Dosen Polkes Tanjungkarang adalah melakukan penyampaian materi teori kewirausahaan dan pelatihan pembuatan sabun menggunakan bahan baku minyak jelantah. Metode pelaksanaan dilakukan sesuai tahapan yaitu koordinasi tim pengabmas dengan mitra yaitu SMPN 27 Kabupaten Pesawaran, penyampaian materi teori, praktik pembuatan sabun.  Sasaran pelaksanaan pengabmas ditujukan kepada Kelompok Ilmiah Remaja (KIR) SMPN 27 Kabupaten Pesawaran. Indikator keberhasilan kegiatan pengabmas ini adalah para siswa yang tergabung dalam KIR memiliki soft skill yang terlihat dari peningkatan nilai hasil pretes dan postes, memiliki life skill  pembuatan sabun cuci piring lunak, serta publikasi ilmiah pada jurnal pengabmas terakreditasi ataupun nonakreditasi. Hasil yang diperoleh dari kegiatan Pengabmas ini adalah hasil pretest nilai terendah 40 dan nilai tertinggi 73, selanjutnya 8 peserta (53%)  dari 15 peserta  memiliki nilai >= 60, sedangkan 47% memiliki nilai =< 60.  Hasil post test, terdapat peningkatan hasil tes dengan nilai terendah 63 dan nilai tertinggi 93, selanjutnya 15 peserta (100%)  dari 15 peserta  memiliki nilai >= 60, KIR SMPN 27 Kabupaten Pesawaran memiliki life skill memurnikan minyak jelantah dan memanfaatkannya menjadi bahan baku pada pembuatan sabun cuci piring lunak.
Pendampingan Kader Lansia Pada Penanganan Konstipasi Dengan Obat Tradisional Tanaman Paederia Scander Lour Merr
Authors: Aji Rustam , Ajhie Sherly Ratih Frichesyarius Santi , Yulaika Ruslina , Shakty Wirawan
Published: November 2022

Penggunaan obat tradisional masih diminati oleh keluarga dan masyarakat di Indonesia, karena obat tradisional tersebut mempunyai beberapa kelebihan, antara lain bahan bakunya mudah diperoleh dan dapat dibudidayakan sendiri di tempat pemukiman. Salah satu tanaman berkhasiat dan berpotensi sebagai obat tradisional yang sering digunakan oleh keluarga dan masyarakat yaitu tanaman sembukan dengan nama ilmiah Paederia scander Lour Merr dari Familia Rubiaceae. Tanaman ini selain digunakan sebagai lalapan, juga dapat mengobati, perut kembung (konstipasi), sehingga berpotensi sebagai Obat Pertolongan Pertama Konstipasi. Pendampingan kader lansia pada penanganan konstipasi dengan obat tradisional tanaman Paederia scander Lour Merr. Penyuluhan dihadiri 6 kader lansia dan 21 lansia, diberikan materi tentang penanganan konstipasi dengan obat tradisional tanaman Paederia scander Lour Merr. Tumbuhan sembukan merupakan bahan obat tradisional, yang berkhasiat untuk mencegah masuk angina, mengobati sistem pencernaan seperti perut kembung. Peserta 2 dari 6 kader lansia serta 4 lansia dari 21 lansia, dapat melakukan redemontrasi cara pembuatan obat tradisional tanaman Paederia scander Lour Merr sebagai obat konstipasi. Masyarakat dapat melakukan pertolongan pertama pada konstipasi dengan obat tradisional tanaman Paederia scander Lour Merr.
Pembentukan Organisasi Bank Sampah di Kelurahan Beringin Jaya Kecamatan Kemiling Kota Bandar Lampung
Authors: Santosa Imam , Barus Linda , Ginting Daria BR , Prianto Nawan , Karami Muhammad
Published: November 2022

Kemiling adalah sebuah Kecamatan di Kota Bandar Lampung, letaknya berada di daerah perbatasan Kota Bandar Lampung. Kecamatan Kemiling terdiri dari kelurahan Beringin Jaya, Kedaung, Kemiling Permai, Kemiling Raya, Pinang Jaya, Sumber Agung, dan Sumber Rejo. Berdasarkan informasi dari Dinas Lingkungan Hidup Kota Bandar Lampung, bank sampah Dinas Lingkungan Hidup (DLH) sudah ada sejak bulan April 2019 tetapi Bank Sampah Dinas Lingkungan Hidup (DLH) di kelurahan Beringin Jaya, Kecamatan Kemiling, Kota Bandar Lampung belum beroperasi secara maksimal. Permasalahan mitra adalah tidak beroperasionalnya bank sampah yang sudah dibangun fasilitas fisiknya. Hal ini disebabkan belum adanya organisasi yang dibentuk untuk mengelola bank sampah di Kelurahan Beringin Jaya. Tujuan kegiatan ini yaitu membentuk organisasi Bank Sampah Di Kelurahan Beringin Jaya, Kecamatan Kemiling, Kota Bandar Lampung. Metode pelaksanaan terdiri dari kegiatan persiapan, pelaksanaan kegiatan pengabdian kepada masyarakat, sosialisasi/ penyuluhan bank sampah, pembentukan organisasi bank sampah, monitoring kegiatan pengabdian kepada masyarakat, evaluasi kegiatan pengabdian kepada masyarakat. Hasil pengabdian ini berupa kegiatan sosialisasi bank sampah kepada warga melibatkan berbagai pihak seperti Dinas Lingkungan Hidup, RT, Kelurahan, petugas pengangkut sampah di Kelurahan Beringin Jaya, PT. Pegadaian Cabang Bandar Lampung, Tim Pengabmas Politeknik Kesehatan Tanjungkarang dan HMJ Jurusan Kesehatan Lingkungan. Hasil lainnya adalah terbentuknya organisasi bank sampah Kelurahan Beringin Jaya yang sudah dibuat strukturnya berdasarkan Surat Keputusan Kepala Kelurahan Beringin Jaya No: 412/21/V58.VI96/2020. Tindak lanjut dari kegiatan ini adalah pendampingan pengoperasian bank sampah, pendampingan ini merupakan kelanjutan dari kegiatan pembentukan bank sampah. Pendampingan pengoperasian bank sampah akan dilaksanakan oleh tim pengabmas yang telah melaksanakan pembentukan organisasi bank sampah
Initiatives to reduce the waiting time to initiate oncological treatment: a scoping literature review
Authors: da Silva Raquel Guimarães Domingos , Araujo Cláudia Affonso Silva
Published: November 2022

Objective.

To identify the managerial actions proposed and employed to reduce the waiting time to initiate oncological treatments in the public health system and its application in Latin America.

Method.

We searched seven databases in December 2020. Search terms were conceptualized into three groups: waiting time, cancer, and terms related to public sector. The eligibility criteria included theoretical or empirical academic articles written in English, Spanish, or Portuguese, that focused on managerial solutions to face oncological healthcare queues' dilemma.

Results.

The search returned 1 255 articles, and 20 were selected and analysed in this review. Results show that most of the proposals are related to the process and people dimensions. The actions related to the process dimension were mainly associated with programming new treatment pathways and integrating cancer systems. People's dimension initiatives referred mostly to task forces and groups of specialists. Some initiatives were related to implementing technological solutions and the technology dimension, mainly concerning radiotherapy devices' acquisition.

Conclusion.

Few studies focus on analysing actions to minimize waiting time to initiate oncological treatments. The prevalence of conceptual and illustrative case studies indicates the lack of research maturity on this theme. Future studies should focus on setting the field's theoretical foundations, considering the existing paradigms, or developing new ones. There is a need for empirical studies applying a multidisciplinary approach to face the oncological treatment waiting time challenge and proposing new and innovative initiatives.
Síntesis de evidencia y recomendaciones: directrices para la profilaxis antibiótica y la elección de antisépticos en las mujeres con parto vaginal instrumentado o cesárea
Authors: Organización Panamericana de la Salud
Published: November 2022

Introducción.

Las infecciones y la sepsis materna durante o después del parto aumentan la mortalidad materna y provocan una carga alta de enfermedad en la Región de las Américas. El riesgo de infección después de la cesárea y el parto instrumentado puede ser reducido mediante el uso de antisépticos cutáneos y profilaxis antibiótica apropiados.

Objetivos.

Sintetizar las recomendaciones desarrolladas por la Organización Mundial de la Salud (OMS) con el fin de mejorar la calidad del cuidado y los desenlaces en salud relacionados con la profilaxis antibiótica de rutina en mujeres con parto vaginal instrumentado, la profilaxis antibiótica de rutina en mujeres con parto por cesárea, la elección de antisépticos y el método de aplicación para la preparación de la piel antes de una cesárea, y la irrigación vaginal con antisépticos en las mujeres en quienes se realiza una cesárea.

Métodos.

Las directrices elaboradas por la OMS siguieron los métodos de elaboración de la directriz GRADE (Grading of Recommendations Assessment Development and Evaluation) del Manual para el desarrollo de directrices de la OMS. Se llevó a cabo una síntesis de las recomendaciones de cuatro directrices de la OMS. Adicionalmente, se realizó una búsqueda sistemática en PubMed, Lilacs, Health Systems Evidence, Epistemonikos y literatura gris de estudios desarrollados en las Américas para identificar barreras, facilitadores y estrategias de implementación, y para establecer indicadores.

Resultados.

Se formularon cinco recomendaciones para la profilaxis antibiótica de rutina en mujeres con parto vaginal instrumentado, la profilaxis antibiótica de rutina en mujeres con parto por cesárea, la elección de antisépticos y el método de aplicación para la preparación de la piel antes de una cesárea, y la irrigación vaginal con antisépticos en las mujeres que tienen una cesárea. Se identificaron barreras y facilitadores para la implementación, y se crearon indicadores de adherencia y resultado.

Conclusiones.

Las recomendaciones formuladas proveen orientación para mejorar la calidad del cuidado y los desenlaces en salud relacionados con la profilaxis antibiótica y la elección de antisépticos en las mujeres con parto vaginal instrumentado o cesárea.
La voluntad política y la gobernanza: claves en la implementación de HEARTS en el Perú
Authors: Hancco Saavedra Jorge , Pérez Jiménez Vivian
Published: November 2022

El objetivo del artículo es describir cómo la gobernanza y la voluntad política han influido en la implementación de la Iniciativa HEARTS para la prevención y el control de la hipertensión arterial en el sistema de salud de Perú.

Se describe el proceso de gobernanza y se realiza un análisis secundario de datos que compara los niveles basales al inicio de la fase 1 de HEARTS con los primeros seis meses de seguimiento en 34 establecimientos de salud.

Se realizó la planificación y organización de la implementación de HEARTS desde el nivel nacional a través de la Dirección de Enfermedades No Transmisibles, contando con la voluntad política de la Alta dirección del Ministerio de Salud y el acompañamiento técnico de la Organización Panamericana de la Salud. La gobernanza se estructuró en 3 niveles: nacional, regional y local; la implementación se apoyó en actores claves de la academia, las sociedades científicas y las Direcciones Regionales de Salud y de las Redes Integrales.

Los resultados encontrados tras los primeros meses de seguimiento evidenciaron un incremento de la cobertura y el control de la hipertensión arterial en la mayoría de los establecimientos intervenidos. El análisis de los factores claves relacionados con la voluntad política y la gobernanza en la implementación de la Iniciativa HEARTS para la prevención y el control de la hipertensión arterial demostró que las funciones de la Alta dirección, para alinear las políticas públicas y priorizar las enfermedades no trasmisibles, en coordinación estrecha y permanente entre los formuladores de política y el Ministro de Salud, tuvieron un efecto positivo en la implementación de la Iniciativa HEARTS en el Perú.
Effect of Some Methods of Weed Control on Growth, Yield And Yield Components of Two Cultivars of Broad Bean (vicia Faba L.) And Associated Weeds under Rain Fed Condition
Authors: Hassan Hadi Murad , Khether Abbas Alo
Published: November 2022

The present study was conducted at Collage of Agricultural Engineering Sciences University of Duhok (Sumel) and Zakho Research Center (Zakho), Kurdistan Region, Iraq, during the growing season 2021-2022 to investigate the effect of different factors includes broad bean cultivars (Aguadulce & Lunga Delle Cascine), herbicide treatments (Control, Basagran 300mL.100L-1, Gallant super 375mL.100L-1, Basagran + Gallant super and Hand weeding) and locations (Sumel and Zakho). The results showed that the Basagran herbicide completely eliminated broad–leaved weeds and Gallant super completely eliminated narrow leaved-weeds. According to study results the best cultivar for Sumel location was Lunga Delle Cascine and Aguadulce for Zakho location. The treatment of Hand weeding in Sumel location and treatment of Gallant super in Zakho location lead to increase all studied parameter
Enhancing the development of refugee-background youth in Aotearoa New Zealand through non-formal education
Authors:   , King Leonie
Published: November 2022

Globally, non-formal education (NFE) plays an important role in youth development. However, while universal approaches to youth development are well researched, there is little research on what influences positive youth development (PYD) for refugee-background youth and how NFE can be adapted to address the inequities experienced by refugee-background youth. In Aotearoa New Zealand, refugee-background youth currently lack equitable access to NFE which supports youth development on an individual level, and which can also build wider societal understanding and empathy across boundaries of class, race, migration status and religion.

To address this gap, this project worked within a transformative epistemology infused with Appreciative Inquiry (AI) to ask:1. What key factors influence positive youth development for refugee-background youth?

2. What key factors lead to positive youth development for refugee-background youth through non-formal education?

3. How might non-formal education be adapted to enable greater positive youth development outcomes for refugee-background youth?

Using a qualitative methodology, I carried out semi-structured interviews with five refugee-background youth or former refugee-background youth and 20 NFE providers, of whom three were former refugees. Through thematic analysis of their reflections, the key factors influencing PYD for refugee-background youth were identified to be a sense of belonging, everyday citizenship, and equitable access to opportunities to participate. NFE also provided refugee-background youth with valuable opportunities to form connections with people, and with the land, culture and history of Aotearoa, to build confidence and to have fun. From this analysis, the research contributes to development practice by developing a PYD model for refugee-background youth, guidelines for NFE providers, and areas for further research.
The Best Option Pricing Model for KOSPI 200 Weekly Options
Authors: Kim Sol
Published: November 2022

This study finds the best option pricing model for KOSPI 200 weekly options. It examines the in-sample pricing, out-of-sample pricing and hedging performances of the short-term options with a maximum maturity of seven days or less, which have not been analyzed in previous studies. The Black and Scholes (1973) model, Ad Hoc Black-Scholes model, and stochastic volatility and jumps models are compared. As a result, one of the Ad Hoc BlackScholes models, the absolute smile model using the strike price as an independent variable shows the best performance. However, its performance is not significantly different from that of the Black and Scholes (1973) model. In the early days of the KOSPI 200 weekly options market, it is confirmed that the Black and Scholes (1973) model continues to show the excellent performance in pricing and hedging options.
The typology of first marriage patterns in Europe
Authors: Majdzińska Anna
Published: November 2022

This paper aims to present an overview of the main demographic characteristics of Europe’s inhabitants entering into first marriages in the 21st c. and the typology of male and female first marriage patterns in European countries in 2010 and 2018. Additionally, a special index is constructed to compare them for nuptiality as an element of the Second Demographic Transition (STD) in 2018. Also calculated are correlations between the types of first marriage patterns and selected demographic and economic indicators. In order to analyse European countries’ populations in terms of first marriages there were used such research methods as descriptive statistics, a cluster analysis, special STD index, and correlation coefficients. The basis of the analysis is data sourced from the Eurostat database. It appeared that the analysis of the males’ and female’s age-specific first marriage rates in the 31 European countries in 2010 and 2018 produced 22 types of first marriage patterns (which can be grouped into seven main categories). In the majority of European countries, the mean age at first marriage was older in 2018 than in 2010. Countries in Central and Eastern Europe are very different from the rest of the continent regarding the types of first marriage patterns. In 2018, the youngest types occurred in post-communist countries (especially in Belarus and Macedonia) and the oldest ones in Spain, Ireland, Denmark, Italy, and Sweden. Older types of first marriage patterns are characteristic of countries that are stronger economically and/or where the second demographic transition takes place at a faster pace.
Factors Affecting the Audit Quality of Government’s Financial Statements (Study at BPK RI Head Office in 2019)
Authors: Challen Auliffi Ermian , Aryani Amelia Dwi
Published: November 2022

Many problems in managing state finances necessitate quality audited financial statements. Quality audits must also be carried out to maintain public trust in The Audit Board for its roles in conducting the audits of the management and responsibility of state finances. This study examines the factors that influence the audit quality of the government’s financial statements, namely independence, competence, integrity, auditor ethics, objectivity, and motivation. The population in this study were auditors of The Audit Board of the Republic of Indonesia (BPK RI) Head Office. The number of samples in this study reached 70 respondents. The research method used is quantitative, with primary data analyzed using multiple regression. The study results showed that independence, competence, integrity, auditor ethics, objectivity, and motivation positively affect the audit quality of the government’s financial statements.
THE ROLE OF IMMUNE CHECKPOINT INHIBITORS IN ANTITUMORAL IMMUNITY
Authors: Dmitrievskaya M. , Ibragimova D. , Useinova A. , Rebik A.
Published: November 2022

Currently immunotherapy is becoming a fairly effective approach in the fight against various forms of malignant neoplasms. This is due to the discovery and use in clinical practice immune checkpoint inhibitors, which antitumoral effect is associated with blockage the signaling pathways CTLA-4 (cytotoxic T-lymphocyte associated protein 4), PD-1 (programmed cell death protein 1), PD-L1 (programmed cell death ligand 1).

The physiological role of immune points is to prevent autoimmune tissue damage by suppressing effectors. How- ever, cancer cells have adapted for using this mechanism to avoid elimination by escape mechanisms from immuno- logical surveillance. This gave impetus to the development of drugs that can inhibit checkpoints, enabling the immune system to destroy tumor cells. Actually, 7 drugs have been registered, which can be divided into three groups according to the mechanism of action: CTLA-4 (pilimumab), PD-1 (nivolumab, pembrolizumab, prolgolimab) and PD-L1 (atezoli- zumab, avelumab, durvalumab) inhibitors. The medicine of the first group inhibits the cellular response at the stage of its activation. The mechanism of action of the second and third groups medicines is aimed at blocking the binding of the PD-1 receptor of lymphocytes and monocytes with PD-L1 ligands and vice versa.

The use of immune checkpoint inhibitors can lead to the occurrence of immune-mediated adverse reactions, the nature and frequency of which differ depending on the class of inhibitors. In this regard, timely diagnosis and treatment of complications is the key to the success of anticancer therapy.
FEATURES OF THE POTENTIAL FIELD STRUCTURE OF THE PPF1 PLASMID AND THEIR INFLUENCE ON THE CHARACTER OF MOTION OF NONLINEAR CONFORMATIONAL PERTURBATIONS – KINKS
Authors: Krasnobaeva L. , Yakushevich L.
Published: November 2022

In this work, mathematical modeling methods are used to study the features of the dynamics of the nonlinear conformational perturbations, kinks, in the pPF1 plasmid. The motion of kinks is considered as the motion of quasiparticles in the potential field of the plasmid. The behavior of such quasiparticles is largely determined by the type and nature of this field. To simulate the movement of the kink along the pPF1 plasmid, the McLaughlin-Scott equation was used. Using the quasi-homogeneous approximation and the block method, the energy profile of the potential field of the pPF1 plasmid was calculated and 2D kink trajectories were constructed in the region located between the genes of the Egfp and mCherry fluorescent proteins, taking into account the effects of dissipation and exposure to a constant torsion field. It was shown that there are threshold values of the torsion field, below and above which the behavior of the kink changes significantly: there is a transition from the cyclic motion of the kink inside the region located between the genes of the fluorescent proteins Egfp and mCherry to the translational motion and exit from this region. Threshold values have been estimated. It was shown that they depend on the nature of the energy profile near the region located between the genes of the fluorescent proteins Egfp and mCherry.
THE EFFECT OF EHF RADIATION WITH A WAVELENGTH OF 5.6 MM ON BIOLOGICAL OBJECTS IN VITRO AND IN VIVO
Authors: Zhorina L. , Matveev I. , Anikeev V.
Published: November 2022

The reason for therapeutic effect of EHF radiation with a wavelength of 5.6 mm has not been precisely established yet. In this work, we conducted research based on the assumptions of other authors. The quenching of singlet oxygen under the influence of EHF radiation was tested using the method of photodynamic action on a suspension of erythrocytes. The suspension of erythrocytes, incubated with the photosensitizer, was then simultaneously irradiated with EHF and radiation at 652 nm. It was found that the dose of the onset of the photodynamic effect when irradiated only with visible radiation and simultaneously with both visible radiation and EHF radiation coincides within the measurement error. Such a result can be caused by insufficient amount of quenched singlet oxygen or by the absence of the quenching effect. The therapeutic effect of EHF radiation is also explained by the expansion of small skin vessels during EHF exposure, which should lead to an increase in the temperature of the skin surface. We have observed the change in the temperature of the palms using a thermal imager when exposed to EHF radiation on the acupuncture point TB5. The observation was carried out for 35 minutes. The irradiation was during 15 minutes. A systemic effect of temperature change synchronously on both palms was found. An increase in the area-average temperature of the palm up to 1.5 K was observed only in 41.7% of cases. The rise in temperature activates the immune system, which, apparently, leads to the therapeutic effect of EHF radiation. At the same time, it has been established that the effect of EHF radiation at a wavelength of 5.6 mm significantly depends on the individual and is not unambiguous.
ROLE OF GURU IN THE SUSTENANCE OF PASSION TOWARDS CLASSICAL DANCE: A QUALITATIVE ENQUIRY
Authors: Marathe Aishwarya , Wagani Rekha
Published: November 2022

Guru is held in great respect and significance in Indian culture since he is the source of all wisdom and learning. India has a rich heritage of several art forms that are closely related to many aspects of life and are still practiced today and passed down from one generation to the next through the "Guru Shishya Parampara". The present study focuses on Indian classical dancers where each shishya has his own unique journey of learning wherein he evolves as a dancer and a human being. During this learning process, the role of guru plays a significant role in the life of the shishya and his overall grooming and continuing the dance journey for years together. Thus, understanding exactly the elements which keep the dancer going is extremely crucial. Therefore, this study aims to explore and understand the possible factors that help classical dancers to continue this long journey and sustain their passion throughout. The present study adopts a qualitative approach in which twelve Indian classical dancers were interviewed telephonically after contacting them using purposive sampling. Thematic analysis was done to illuminate the hidden meaning of the experiences shared by participants which reflected dancers’ experiences and perceptions regarding their guru and how it has shaped them as dancers and human beings both. In addition to this, it also the dancers also expressed how they could sustain their interest and passion for Indian classical dance and could pursue it further.
Lesbian Motherhood and Artificial Reproductive Technologies in North America: Race, Gender, Kinship, and the Reproduction of Dominant Narratives
Authors: Smith Zoey
Published: November 2022

This paper reviews current ethnographic literature on lesbian motherhood as it relates to artificial reproductive technologies (ART) through intersectional, biopolitical and critical-race frameworks. I argue that white, lesbian intending mothers intersecting identity markers of whiteness and queerness place them in a unique position within ART discourses. ART functions as a biopolitical mechanism which aims to normalize and naturalize privilege in hierarchized power structures, while suggesting that the meanings that it produces are objectively scientific rather than socially constructed. I suggest that ART mechanizes white lesbian women’s insecurities as queer women, nearing the falsified construction of ideal motherhood, by exerting pressure on them to conform and therefore, reproduce dominant reproduction narratives. Simultaneously, I assert that white, lesbian, intending mothers’ positionality could enable critical interrogation into the harmful social stratifications that ART perpetuates based on race, class, ability, and sexuality. In sum, a review of relevant literature is used to posit that women privileged within dominant ART discourses must utilize that privilege to create meaningful change.
Using Metaphors of Contagion: How Framing Obesity as ‘Epidemic’ Shapes Cultural and Medical Understandings of Noncommunicability and ‘Fatness’
Authors: Wristen Amara
Published: November 2022

This paper explores the contestations regarding the use of the term ‘epidemic’ in obesity discourses. On one side, obesity studies are increasingly demonstrating links which suggest the condition is communicable, thus possibly warranting an ‘epidemic’ framework. On the other side–to which I position this paper–obesity remains understood as noncommunicable; therefore when the notion of ‘epidemic’ is employed, it is recognized to be metaphorical. Drawing on the works of critical scholars, this paper argues that the framing of obesity as ‘epidemic’ has more harmful consequences on prevailing cultural and medical understandings of fatness.
Paleopathology, Entheseal Changes, and Cross-Sectional Geometry: The Zooarchaeology of Working Animals
Authors: Sick Jess , Kohut Grace
Published: November 2022

Morphological changes in the skeletons of working animals such as reindeer, horse, and cattle have long been observed and documented in the archaeological record. Activities such as riding, carrying cargo on their backs, and pulling vehicles like sleds and ploughs throughout an animal’s life history cause alterations and variations to skeletal tissue. Such alterations include paleopatho­logical lesions, entheseal changes (EC)—alterations in muscle, tendon, and ligament attachment sites on bone—and variations in cross-sectional bone geometry (CSBG). These clues are helpful for reconstructing human-animal relationships in faunal remains of our archaeological past. However, other factors influence the morphological appearance of skeletal tissue besides working activities, such as age, sex, body size, nutrition, genetics, environmental factors, and management by human caretakers. This article explores how paleopathological lesions, EC, and CSBG in faunal skeletal remains are examined to reconstruct working activity and changes to human-animal rela­tionships in the archaeological record. In particular, we discuss two primary topics of inquiry: (1) a review of paleopathological identifiers in working animals such as cattle, horse, camel, and rein­deer; and (2) how EC and CSBG are understood in terms of bone functional adaptation, and their application in working and non-working animals such as reindeer and horse. Next, we analyze each topic highlighting their benefits and limitations, including how they contribute to archeolog­ical understandings of human-animal relationships in the past, as well as their implications for future research.
Korelasi antara Nilai Pengetahuan dengan Perilaku Pedagang dalam Penggunaan Boraks pada Tahu di Pasar Tradisional Se-Kota Mataram
Authors: Sari Surya Meka Novita , Syamsun Arfi , Nurbaiti Lina
Published: November 2022

Latar Belakang: Tahu adalah salah satu makanan yang paling sering ditambahkan dengan boraks. Boraks adalah antiseptik yang sering digunakan pada produk kayu atau tekstil, namun berbahaya bagi tubuh jika ditambahkan ke makanan. Hari-hari ini kami sering menemukan boraks sebagai bahan makanan tambahan. Tingginya jumlah boraks yang digunakan dalam makanan mungkin disebabkan oleh kurangnya pengetahuan tentang bahan ini. Para produsen makanan berasumsi bahwa penambahan boraks dapat membuat makanan bertahan lebih lama dan lebih menarik. Dengan demikian, pengetahuan yang cukup tentang boraks dan pengaruhnya pada tubuh saat ditambahkan ke dalam makanan sesuai kebutuhan.

Tujuan: Tujuan dari penelitian ini adalah untuk mengukur korelasi antara pengetahuan dan penggunaan boraks dalam tahu di pasar tradisional, kota Mataram.

Metode: Ini adalah penelitian observasional menggunakan metode cross-secctional. Sampel untuk penelitian ini adalah 52 penjual tahu di pasar tradisional di kota Mataram. Data dikumpulkan menggunakan kuesioner dan wawancara terstruktur. Data dianalisis menggunakan analisis bivariat dengan uji korelasi Spearman.

Hasil: Hasil analisis bivariat Spearman menunjukkan bahwa p = 0,000 (p <0,05) dan r = 0,710 yang berarti bahwa ada korelasi yang positif (+) kuat. Terdapat 44,23% responden dengan pengetahuan baik, 55,76% responden dengan pengetahuan sedang dan tidak ada responden yang memiliki pengetahuan buruk tentang boraks. Adapun perilaku, 82,69% memiliki perilaku baik, sedangkan 17,31% memiliki perilaku sedang dan tidak ada yang berperilaku buruk.

Kesimpulan: Ada korelasi antara pengetahuan dan perilaku penjual tentang penggunaan boraks dalam tahu. Semakin tinggi pengetahuan tentang boraks dan bahayanya ketika digunakan dalam makanan, semakin baik perilaku penjual, untuk tidak menambahkan boraks ke dalam tahu.
Uji Diabetes secara Non-Invasif Berbasis Konsentrasi DNA Saliva
Authors: Prayitno Oktavianus , Asmara I Gede Yasa , Geriputri Ni Nyoman
Published: November 2022

Latar belakang: Diabetes melitus merupakan suatu kelainan kompleks dari multisistem yang ditandai dengan adanya insufisiensi sekresi insulin secara relatif maupun absolut. Permasalahan saat ini berada pada monitoring diabetes melitus yang secara luas masih menggunakan jarum yang terkadang menyakitkan pada saat pengambilan darah. Dalam saliva ditemukan susunan bahan yang dapat dianalisis (DNA) yang dapat digunakan sebagai biomarker untuk translasi dan aplikasi klinis.

Tujuan: Penelitian ini dilakukan untuk mengkaji kemungkinan penggunaan konsentrasi DNA saliva sebagai bahan uji non-invasif pada penderita diabetes melitus.

Metode: Penelitian ini merupakan studi komparatif. Sampel yang digunakan adalah saliva yang berasal dari 20 orang dan terbagi menjadi 2 kelompok. Kelompok orang dengan diabetes (D), dan kelompok orang normal/tanpa diabetes (N). Saliva yang terkumpul disentrifugasi dan diambil peletnya, Proses isolasi DNA dilakukan dengan tahapan Cell Lysis, DNA Binding, Pencucian, dan Elusi. Setelah didapatkan isolasi DNA dilakukan proses penghitungan konsentrasi DNA saliva dengan menggunakan spectrophotometer NanoDrop. Perbedaan konsentrasi DNA saliva diuji dengan uji Independent sample t test.

Hasil: Rerata konsentrasi DNA saliva pada D dan N masing-masing  30.12 ng/Î¼l dan 11.61 ng/Î¼l. Berdasarkan data tersebut, terlihat perbedan konsentrasi DNA saliva yang signifikan secara statistik ( p<0,05).

Simpulan: Konsentrasi DNA saliva pada orang dengan diabetes mengalami peningkatan bila dibandingkan dengan konsentrasi DNA saliva pada orang tanpa diabetes, hal ini menunjukkan konsentrasi DNA saliva dapat digunakan sebagai bahan uji non-invasif pada penderita diabetes melitus.
Chronic Lyme disease presented with gastroparesis
Authors: Özlem Özyurt , Vedat Turhan
Published: November 2022

We present a case of a 54-year-old White man who was admitted to our clinic for evaluation of gastroparesis. His gastroparesis was severe and unresponsive to previous treatments. Darkfield microscopy revealed the presence of spirochetes and corkscrew-shaped bacteria; although Lyme immunoglobulin M (IgM) and immunoglobulin G (IgG) Western Blot testings were negative. The patient was diagnosed with Chronic Lyme disease and recovered with antibiotherapy. We outline a rare case of dysmotility syndrome; a unique presentation of cChronic Lyme disease and emphasize the limitation of tools necessary in diagnosing Lyme disease
Mediation and moderation effect of mathematics interest and teaching quality between self-concept and mathematics achievement
Authors: Fosu Michael , Arthur Yarhands Dissou , Boateng Francis Ohene , Adu-Obeng Benjamin
Published: November 2022

Purpose: This study investigated the mediation and moderation effect of mathematics interest and teaching quality on the relationship between self-concept and mathematics achievement.

Design/methodology/approach: The study was conducted at Sakafia Islamic Senior High School (SHS) and Kumasi Academy SHS in Ghana. A sample comprised of 300 students who offered general arts, general science, and home economics were randomly selected from a population of 1,200. The study adopted a descriptive survey and analysis such as exploratory and confirmatory factor analysis, discriminant validity, and reliability analysis from Cronbach’s alpha was estimated using SPSS (version 23) and Amos (version 23).

Findings: From the hypothesis, the findings revealed that self-concept partialy mediate mathematics achievement through mathematics interest and teaching quality also showed moderating effect between interest and achievement. The study also found out that self-concept, mathematics interest and teaching quality have direct effect on students’ performance.

Research limitations/implications: The study investigated the moderation effect of teaching quality, which was found to be insignificant. This is an imperative for further study to critically analyzed it effect on other antecedents.

Practical implication: The study informed teachers teaching mathematics and in other different programs to be equipped with knowledge of how students perceive mathematics so as to select the appropriate teaching approach to influence their interest and belief in the study of mathematics.

Originality/value: There are studies by some researchers combining these variables under study with other factors to influence students’ performance however, little attention was on the effect mathematics interest and teaching quality to impact student performance through self-concept.