bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengaruh Pertumbuhan Pendapatan Usaha, Perputaran Piutang dan Perputaran Persediaan Terhadap Peningkatan Laba Bersih PT. Mayora Indah Tbk
Authors: Ningsih Putu Tirta Sari , Nurcahya Nilam
Published: May 2022

The company always aims to increase the profit that it wants to obtain. one way to monitor the receivable turnover, can increase the company's business income. As well as always monitoring the supply of merchandise so that there is no deposition of manufactured goods. This study aims to determine the effect of operating revenue, accounts receivable turnover and inventory turnover against net income at PT. Mayora Indah Tbk. Net income comes from income, expense, profit and loss transactions. These transactions are summarized in the income statement. This study uses quantitative methods and uses secondary data on the financial statements of PT. Mayora Indah Tbk. The technical analysis of the data used in this study is the Classic Assumption Test, Multiple Regression Test, Hypothesis Test (t test and f test) and the Determination Coefficient Test using SPSS version 24. From the results of the f test data analysis can be seen f count > ftabel (29.152 > 19.16) with a significant value of 0.033 < 0.05 that the independent variables simultaneously have a significant effect on net income. And partially (t test) variables of operating revenue and inventory turnover have a significant effect on net income but for accounts receivable turnover there is no significant effect on net income. Through testing the Determination Coefficient obtained Adjusted R Square (R2) of 94.4% net profit can be explained by the three independent variables, while the remaining 5.6% is explained by other variables outside the research model. Based on the results of the study, it can be concluded that operating revenue negatively affects net income, accounts receivable turnover has no effect on net income and inventory turnover has a positive effect on net income. While simultaneously the variables of business income, accounts receivable turnover and inventory turnover have a positive effect on net income.Keywords: Operating Revenue, Receivable Turnover, Inventory Turnover, Net Income.Â
Analisis Strategi Model Bisnis Produk Industri Kreatif Dengan Pendekatan Model Canvas (Studi Pada Industri Batik Laweyan Kota Surakarta)
Authors: Hariani Danarti , Sutrisno Sutrisno
Published: May 2022

Currently, the world is entering the industrial era 4.0, namely the creative economy industry which develops creative ideas. Changes in consumers, technological developments and a competitive climate require the industry to renew its strategy by making innovations and constructive efforts so that the creative industry must improve itself to be able to compete in local and global markets. The Batik industry is one of the industries that is interesting to be studied, this is because batik is one of the world cultural heritages from Indonesia which must be protected and preserved. Surakarta is one of the cities which is famous for its Batik characteristics. As a design-based cultural city, batik is one of the leading products. Batik Solo has been proposed as a design-based creative city to the United Nations (UNESCO). The object of the research taken is the batik industrial area in Kampung Batik Laweyan, because Laweyan is the origin of batik created in Surakarta. Competition in the national and world batik industry will affect business development, so it requires a special strategy in facing competition, as well as using a model to structure its business. The purpose of this study is to determine the strategic model of the Laweyan batik industry with a canvas model by describing the facts of the economic potential of the Laweyan Batik industry and alternative business strategies with a canvas model approach in facing competition and maintaining the existence of Kampung Batik Laweyan as a sustainable batik industry icon in Surakarta.Keywords: Batik Laweyan Surakarta, Model Canvas, Creative Industry
Pengaruh Pendapatan dan Biaya Operasional Terhadap Laba Bersih pada Distributor Gas LPG 3 Kg di Wilayah Bogor Tahun 2014-2018
Authors: Ependi Ependi
Published: May 2022

Perusahaan pada dasarnya memiliki tujuan yang sama yaitu meningkatkan laba. Laba merupakan ukuran profitabilitas perusahaan secara keseluruhan yang dapat digunakan untuk mengevaluasi kinerja perusahaan. Faktor penting dalam mencapai tujuan tersebut sangat ditentukan oleh pendapatan yang diperoleh dalam setiap kegiatan dan biaya yang harus dikeluarkan untuk mencapai keuntungan yang maksimal. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh Pendapatan dan Biaya Operasional terhadap Laba Bersih. Penelitian ini menggunakan metode kuantitatif dan menggunakan data sekunder yang diambil dari Laporan Laba Rugi dan Keuangan perusahaan tahun 2014-2018. Analisis data menggunakan Uji Asumsi Klasik, Analisis Regresi Berganda, Uji Hipotesis, dan Uji Koefisien Determinasi. Dari koefisien regresi simultan diperoleh fhitung 56,456 dari ft 5,32 yang berarti pendapatan dan biaya operasional berpengaruh terhadap laba bersih. Dan koefisien regresi parsial untuk pendapatan diperoleh thitung 5,281 ttabel 2,262 yang artinya ada pengaruh terhadap laba bersih, sedangkan koefisien regresi parsial untuk biaya operasional diperoleh thitung 0,638 ttabel 2,262 yang artinya tidak ada pengaruh terhadap laba bersih. Dari penelitian ini dapat disimpulkan bahwa Pendapatan dan Biaya Operasional berpengaruh terhadap Laba Bersih. Serta terdapat kontribusi pendapatan dan biaya operasional penyaluran LPG 3 kg di wilayah Bogor sebesar 97% dari laba bersih.
Bagaimana Pengaruh Keaktifan Belajar Terhadap Sikap Siswa pada Mata Pelajaran IPA di Sekolah Menengah Pertama yang ada di Palangkaraya?
Authors: Kartidie Kartidie , Gunarhad Gunarhad , Petriati Petriati
Published: May 2022

Tujuan penelitian: Penelitian ini bertujuan mengetahui apakah ada pengaruh keaktifan belajar siswa terhadap sikap siswa pada mata pelajaran IPA di SMP yang ada di Kota Jambi.
Metodologi: Penelitian ini menggunakan metode penelitian campuran dengan desain explanatory. Populasi dalam penelitian ini adalah seluruh siswa SMP Negeri 3 Palangka Raya, siswa SMP Negeri 14 Palangka Raya, dan siswa SMP Ngeri 16 Kota Palangka Raya. Dengan jumlah sampel yang digunakan sebanyak 250 siswa. Data penelitian ini diperoleh dengan menyebarkan angket kekatifan belajar siswa dan angket sikap siswa pada mata pelajaran IPA, serta melakukan wawancara dengan siswa. Selanjutnya data dianalisis secara kuantitaif  tipe regresi sederhana serta dengan statistik inferensial.
Temuan utama: Hasil penelitian menunjukkan bahwa keaktifan belajar siswa mempengaruhi sikap pada mata pelajaran IPA dengan sumbangsih pengaruh 15.2% sedangkan sisanya 84.8% dipengaruhi oleh faktor-faktor lain yang tidak diteliti pada penelitian ini yang selanjutnya disebut variabel intervening. Selanjutnya dari perhitungan uji-t didapatkan nilai thitung lebih besar dari ttabel (20.299  1.650971), yang artinya Ha (diterima) atau terdapat pengaruh keaktifan belajar siswa terhadap sikap pada mata pelajaran IPA. Dari hasil pengaruh tersebut diperoleh persamaan regresinya yaitu Y = 111.113 + 0.334x. sehingga dapat disimpulkan apabila siswa memliki keaktifan belajar yang baik, maka siswa juga akan menunjukkan sikap yang baik pula dalam belajar, terutama dalam belajar IPA.
Keterbaruan penelitian: Keterbaruan dari penelitian ini yaitu adanya pengaruh dari kearifan lokal terahadap sikap siswa dalam mata pelajaran IPA.
Pemahaman Siswa Terhadap Hasil Belajar Fisika Pada Materi Suhu Dan Kalor Di Sma Negeri 2 Kota Jambi
Authors: Sadiah Halimatul
Published: May 2022

Tujuan penelitian: Tujuan penelitian ini adalah mengetahui pengaruh pemahaman siswa terhadap hasil belajar fisika pada materi Suhu dan Kalor. Metodologi: Subjek penelitian ini adalah siswa SMA N 2 Kota Jambi kelas XI MIPA 1, XI MIPA 2, XI MIPA 3 tahun ajaran 2020-2021. Jenis penelitian ini yaitu deskriptif kuantitatif. Instrumen penelitian yaitu angket test soal suhu dan kalor 25 buah soal dengan sasaran siswa 45 orang. Temuan utama: Pemahaman  siswa terkait konsep suhu dan kalor masih cenderung rendah. Hal ini dapat dilihat dari skor pemahaman konsep siswa dalam menjawab soal konseptual yang mendasar masih cenderung rendah. Kesimpulan dari penelitian ini yaitu Pemahaman siswa Kelas XI SMA Negeri 2 Kota Jambi  dikategorikan “Masih Rendah”. Sedangkan hasil belajar fisika pada materi suhu dan kalor siswa Kelas XI SMA Negeri 2 Kota Jambi dikategorikan “Masih Rendah”. Keterbaruan penelitian: guru dapat menggunakan konsep pemahaman siswa untuk menentukan keberhasilan belajar.
Plantamajoside Inhibits the Growth of Acute Myeloid Leukemia Cells by Modulating NF-κB and PI3K/AKT Signaling Pathways
Authors: Zhou Xiaolu , Wang Guochuan , Wu Qiongsheng , Yang Mei
Published: May 2022

Acute myeloid leukemia is a highly invasive and heterogeneous malignant tumor. Plantamajoside, a natural compound extracted from Plantago asiatica L., has been shown to exhibit the inhibitory effect on a variety of tumors. Herein, we have evaluated the nature of the effect of plantamajoside on MOLM-13 and HL-60 cells—two acute myeloid leukemia cells—by measuring parameters such as cell viability, proliferation, apoptosis rate, cell cycle arrest, and relative expression of BCL2-associated X protein, B-cell lymphoma 2 protein, cleaved-caspase-3, protein kinase B, and p65 proteins. These measurements led us to conclude that plantamajoside suppresses the proliferation of both MOLM-13 and HL-60 cells via inhibiting nuclear factor-kappa B and phosphatidylinositol 3-kinase/protein kinase axis in a dose-dependent fashion.
Wavelength Allotment for All-to-All Broadcast in WDM Optical Bidirectional ring with 3-Length Extension
Authors: Manoharan K. , Sabrigiriraj M.
Published: May 2022

All-to-all broadcast communication, distributing messages from each node to every other node, is a dense communication pattern and finds numerous applications in advanced computing and communication networks from the control plane to datacenters. A ring network topology is one of the important regular network topologies due to its simple structure, high speed, easy to extend and tolerant to link and node failures. Few researchers recommended connecting the alternate nodes of the ring with additional fibers in the ring network, to support increased call connection probability, higher tolerable to multiple link and node failures, enormous traffic handling capability and improved survivability. To reduce the complicatedness and cost of the network, it is essential to reduce the wavelength-number required to establish all-to-all broadcast in wavelength-division multiplexed ring network. In this paper, a ring network is extended by directly linking all nodes which are separated by two intermediate nodes with additional fibers and this network is referred as ring with 3-length extension. The wavelength allotment methods are proposed for realizing all-to-all broadcast over a WDM optical bi-directional ring with 3-length extension under multiple unicast routing model using a two-stage heuristic algorithm. The heuristic algorithm is developed to identify non-overlapping connections and an explicit wavelength allotment method based on the output of the heuristic technique is given. The result obtained shows that wavelength-number required atmost to establish all-to-all broadcast in a bi-directional ring with 3-length extension is reduced by a minimum of 57% and a maximum of 66% when compared to bi-directional primary ring. Similarly, the wavelength-number required atmost to establish all-to-all broadcast in a bi-directional ring with 3-length extension is reduced by a minimum of 20% and a maximum of 33% when compared to a bi-directional ring with 2-length extension.
An Efficient Convolutional Neural Network Model for Brain MRI Segmentation
Authors: El Kader Isselmou Abd , Xu Guizhi , Shuai Zhang , Brahim El Maalouma Sidi , Saminu Sani
Published: May 2022

Medical image analysis is a very interesting research area, and it is a significant challenge for researchers. Due to the complexity of the brain structure, accurate diagnosis of brain tumors is extremely difficult. In recent years, research focused on medical image processing to solve this problem by relying on deep learning techniques, and it has achieved good results in this field. This paper proposes an efficient convolutional neural network model for MR brain image segmentation and analysis. The novel model consists of segmentation efficient-CNN and pre-efficient-CNN blocks for dataset diminution and improvement blocks. The unique efficient-CNN is specially designed according to the model proposed by ASCNN (application) CNN-specific) to perform unidirectional and transverse feature extraction and tumor and pixel classification. The recommended Full-ReLU activation feature halves the number of cores in a high-coil filtered winding layer without reducing process quality. In this specific efficient-CNN consists of 8 convolutional layers and 110 kernels. The experiment results were done using the MR brain database from the Arizona university, including eluding with and without tumor images. The proposal model achieved an accuracy of 97.2% to 98%, which proves the efficiency of the model and its ability to assist in the early diagnosis of brain tumors with sufficient accuracy to support the doctors' decision during diagnosis.
Linguistic and non-linguistic cues to acquiring the strong distributivity of each
Authors: Knowlton Tyler , Gomes Victor
Published: May 2022

The universal quantifier each is more strongly distributive than its counterparts every and all. It forces predicates to apply to individuals, it more often supports pair-list readings, it’s unfriendly to genericity, and, in psycholinguistic tasks, it encourages encoding and remembering individual properties. But what information leads learners to acquire this aspect of em>each’s meaning? We explore the hypothesis that, because of its meaning, parents are more likely to use each in situations that independently promote representing the domain of quantification as a series of individuals (as opposed to a group). In line with this, we find that in child-directed speech, parents often use each to quantify over small numbers of physically present things. The same cannot be said of every and all. Because such situations are independently known to trigger object-files – the mind’s system for representing individuals – we argue that these cases are ideal for acquiring the individualistic aspect of each.
The Open Letter: Responses and recommendations
Authors: Kastner Itamar , Kotek Hadas , Anonymous Anonymous , Dockum Rikker , Dow Michael , Esipova Maria , Green Caitlin M. , Stickles Elise , Snider Todd
Published: May 2022

Since its publication in July 2020, the Open Letter to the LSA regarding Steven Pinker has evoked many passionate reactions. The letter argued that Pinker's public statements are inconsistent with the LSA’s anti-racist values, asking to revoke Pinker's status as LSA Fellow and to remove him from the LSA's list of Media Experts. Signed by 600+ linguists, the letter has generated vigorous debate within and outside linguistics. This talk pushes the discussion forward by analyzing the responses to the letter using the tools of our profession – pragmatics and discourse analysis – and further suggesting an approach for examining the power of all individuals in the field.
Double plurals in Breton: Evidence for a split analysis of plurality
Authors: Robinson Dakota
Published: May 2022

Traditional analyses of plurality situate number features within Num(ber)P between NP and DP projections. However, such an analysis does not easily account for all of the properties of plural forms cross-linguistically, particularly those that surface with multiple plural morphemes affixed simultaneously to a single stem. Kramer (2016b) proposes that number features can be exponed on the n category head in addition to on the Num head, generating plural nouns with either one or two plural suffixes. Yet, questions remain about the ability of this analysis to generate multiple plurals in other languages, such as Breton. In this paper, I test the predictions made by Kramer on Breton, which has a complex set of possible plural nominal forms. I present a morphosyntactic description of Breton noun phrases from the framework of Distributed Morphology (Halle & Marantz 1993), and I propose several adjustments to the theory of split n/Num plurality as presented by Kramer (2016a). This analysis is an alternative to previous descriptions of Breton number that situate double plurals within theories of lexicality (e.g., Acquaviva 2008) or that assume a strict dichotomy between inflectional and derivational morphology (e.g., Stump 1989, 1990).
Encoding transfer of possession events
Authors: Chen Yiran , Papafragou Anna , Trueswell John
Published: May 2022

The present study focuses on the linguistic and non-linguistic encoding of giving and taking events. For both English and Mandarin Chinese speakers, we find that the linguistic encoding of these transfer events respects the Thematic Hierarchy and the Source-Goal asymmetry (Exp.1 and 2): Agents are mentioned more often than Patient; Goals are encoded more often than Sources. However, in non-linguistic representation, the bias against Sources is not observed (Exp.3 and 4): Giver, Givee, Taker and Takee are equally prominent in memory. Taken together, our results support linguistic theories extending Source/Goal paths to Transfer of Possession events and call for a finer-grained account of homology between linguistic and non-linguistic encoding of events.
MESLEKİ VE TEKNİK ANADOLU LİSESİ ÖĞRENCİLERİNİN OKULA YABANCILAŞMAYA YÖNELİK GÖRÜŞLERİ VE MESLEKİ EĞİTİME YÖNELİK TUTUMLARI
Authors: ÖZTÜRK Zeynep , GÖKSOY Süleyman
Published: May 2022

Bu araştırmada Mesleki ve Teknik Anadolu lisesindeki 11 ve12. sınıf öğrencilerinin okula yabancılaşmaya yönelik görüşleri ve mesleki eğitime yönelik tutumları ele alınmıştır. Araştırmanın evrenini Düzce’nin Merkez ilçesindeki 339 Mesleki ve Teknik Anadolu Lisesi öğrencisi oluşturmaktadır. Araştırmada ilişkisel tarama modeli kullanılmıştır. Araştırmanın sonucunda, Mesleki ve Teknik Anadolu Lisesindeki öğrencilerin okula yabancılaşma düzeyleri genel anlamda düşük çıkmıştır. Bunun yanında mesleki eğitime yönelik tutum düzeylerinin ise yüksek çıkarak olumlu tutuma sahip olduklarını göstermesinin yanında, sınıf düzeyleri arasındaki fark 12. sınıf öğrenciler lehine anlamlı bulunmuştur. Okutulan programlar açısından elde edilen bulgulara bakıldığında ise okula yabancılaşma ve anlamsızlık ile sosyal uzaklık alt boyutları açısından anlamlı bir fark bulunmamasına karşın, sağlık meslek lisesi öğrencilerinin güçsüzlük boyutunda, ticaret lisesi öğrencilerinin de kuralsızlık boyutunda daha yüksek ortalamaya sahip oldukları, dolayısıyla bu alt boyutlarda daha çok okula yabancılaştıkları görülmüştür. Mesleki eğitime yönelik tutumların da okul türleri açısından farklılaştığı görülmektedir. Bu fark sağlık meslek lisesi öğrencilerinin lehinedir. Bunun yanında okula yabancılaşmanın alt boyutlarından olan güçsüzlük boyutunda kız öğrenciler, kuralsızlık boyutunda ise erkek öğrenciler daha fazla yabancılaşmaktadırlar. Öğrencilerin okula yabancılaşmaya yönelik görüşleri ve mesleki eğitime yönelik tutumları arasında ise negatif yönlü orta düzeyde ilişki mevcuttur. Öğrencilerin okula yabancılaşma ve alt boyutlarının düzeyleri arttıkça mesleki eğitime yönelik tutum düzeyleri düşmektedir.
“DERS ARAŞTIRMASINA DAYALI DİSİPLİNLER ARASI ETKİNLİK PLANI GELİŞTİRME”: TASARIM BECERİ ATÖLYELERİ ÖĞRETMEN EĞİTİMİ MODEL ÖNERİSİ
Authors: GÜLHAN Filiz
Published: May 2022

Disiplinler arası yaklaşımlar, çağımız eğitim anlayışının gereklerinden biri olarak görülmektedir. Ders araştırması (ders imecesi) modeli dünyanın birçok ülkesinde uygulanan ve verimli sonuçlar elde edilen bir mesleki gelişim yaklaşımı olarak karşımıza çıkmaktadır. Öte yandan ülkemizdeki eğitim sahamızı değerlendirdiğimizde disiplinler arası, iş birlikli, uygulamalı çalışmaların geliştirilmesine yönelik ihtiyaçlar olduğu görülmektedir. Özellikle MEB 2023 Eğitim Vizyonu belgesindeki “Tasarım Beceri Atölyeleri” bu ihtiyacın hem tespit hem de çözüm yerleri olarak görülmekle beraber, geliştirilen modelin atölyeler odaklı kullanılmasıyla öğretim niteliğinin arttırılması ve öğretmenlerin mesleki gelişimlerinin sürdürülebilirliği açısından önem arz ettiği düşünülmektedir. Bu araştırmada disiplinler arası yaklaşımlar ile ders araştırması modelinin bir araya getirilmesiyle “Ders Araştırmasına Dayalı Disiplinler Arası Etkinlik Planı Geliştirme Modeli” önerisinin ortaya konması amaçlanmıştır. Modelin özellikle Tasarım Beceri Atölyelerinde kullanılmasına yönelik düşüncelerden ve sahada oluşabilecek muhtemel yansımalardan yola çıkılarak öneriler geliştirilmiştir.
Effectiveness and Safety of Chinese Patent Medicine for Functional Constipation: A Systematic Review and Network-Meta Analysis
Authors:   Centre for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Zheng You-you , Liang Ning , Liu Long-kun , Sun Wei-jia , Wang Xue-hui , Sun Yu-xin , Chen Yun-ru , Han Xiao-xia , Liu Zhao-lan , Liu Jian-ping
Published: May 2022

Review question / Objective: To evaluate the effectiveness and safety of Chinese patent medicine in treatment of functional constipation by using the Network Meta-Analysis. 1. Types of participants: participants diagnosed as functional constipation according to Rome III, Rome IV or other published criteria or guidelines. No limitation on types of FC, age, sex, and nation. Children and pregnant women were excluded. Participants who had other constipation-related diseases including irritable bowel syndrome, functional defecation disorders and opioid-induced constipation were excluded. 2 Types of Interventions. Chinese patent medicine which have been registered with the approval batch number beginning with “Z,” approved by Chinese National Medical Product Administration (NMPA), used alone or in combination with Polyethylene Glycol, Lactulose, Bisacodyl, Prucalopride Succinate, probiotic, or Mosapride which recommended by latest clinical guidelines released by authorized organizations. The dosage, formulation, and route of administration of Chinese patent medicine were not limited. 3 Types of control. Registered Chinese patent medicines used alone, Polyethylene Glycol, Lactulose, Bisacodyl, Prucalopride Succinate, probiotic, Mosapride which recommended by latest clinical guidelines released by authorized organizations or placebo were eligible. 4 Types of outcomes. Primary outcomes were the clinical effect, score of dyschezia and defecation time. Secondary outcomes were adverse events and recurrence rate. 5 Types of study design. Parallel randomized controlled trials (RCTs) were included. Conference abstracts were excluded if full articles were not available.
FINDING MUSIC GENRE
Authors:   Assistant Professor, CSE Sreyas Institute of Engineeringand Technology, Telangana, India, Yasmeen Lubna , Ritish Bharadwaj K M ,   CSE, Sreyas Institute of Engineering and Technology, Telangana,India, Sai Prakash Reddy Chiluka ,   CSE, Sreyas Institute of Engineering and Technology, Telangana,India, Sandeep Vanaparthi ,   CSE, Sreyas Institute of Engineering and Technology, Telangana,India, Vishal Yadav Chatharasi ,   CSE, Sreyas Institute of Engineering and Technology, Telangana,India
Published: May 2022

The main aim of this work is to design a tool to automatically classify the different music genres. Usually, people carry their favourite songs on mobile. There are many genres of music, and these genres are different from each other, resulting in people having different preferences of music. With the help of machine learning techniques, we can provide a classified list of songs to the smartphone user. As we know, many music streaming platforms have different types of music genres which are separated based on the song. We can create a similar one on our own, which can classify audio files into various genres. Classification is done using low-level features related to frequency and time within the wav file. The features are extracted, and predictions are made using the nearest neighbours. Acoustic features generated from these networks have been used for music genre classification on a data set
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Authors:   Research Scholar, University Business School (UBS), Panjab University (PU), India, Rini Ms , Sharma Dr. Sanjeev Kumar ,   Professor, University Institute of Applied Management Sciences (UIAMS), Panjab University (PU) India
Published: May 2022

Internet of Things (IoT) as an efficient and novel technological system has revolutionized the consumer market. IoT has provided ease of living and convenience to consumers through its innovative offerings. Over the years, scholars have focused extensively on several domains concerning IoT products, while the domain of “smart” speakers with embedded IoT technology has been less explored. Moreover, such studies have been confined to the Western and developed regions, and less focus has been on emerging markets. Therefore, the objective of this study is to identify the factors influencing the adoption of “smart” speakers in India. This study proposes a unique framework combining constructs from the UTAUT-3 framework in addition to privacy, security, and trust dimensions of technological adoption. Besides, the moderating role of age, income and education were analyzed employing SPSS 26, AMOS 25 analytical tools. The sample size of 330 respondents was incorporated for the study. The results reveal significant moderation of the education, age, and income in the association between users’ adoption intentions towards smart speakers and ten antecedents identified for the framework. The study contributes theoretically to the growing body of research on IoT adoption along with practical implications for marketers from the Indian consumer’s perspective.
People of a Lost Country: Exile and Sense of Dislocation Transmitted in the Poems of Tenzin Tsundue
Authors:   Fmr. Assistant Professor, Department of English, Jyoti Nivas College Autonomous, Bangalore - 370020, Chauhan Dr. Mansi
Published: May 2022

The proposed research paper seeks to study the notion of home which has been defined and redefined in various ways predominantly in diasporic, partition and exile literature as history and heritage of thousands of years linked to it and the way this association was broken. Home became a floating signifier with each literary piece penned down with angst of exile. Tenzin Tsundue, an unusual blend of an activist and a writer articulates collective consciousness of the Tibetan people in exile. The target poems published in Kora, a collection of stories and poems written by Tenzin Tsundue analyze how the word ‘exile’ is catastrophic in many ways, how excruciating it is to untie with home/nation.
ISOLATION, EXTRACTION, ANTIOXIDANT ACTIVITY AND STANDARDIZATION OF NATURAL DYES FROM BIXA ORELLANA L. SEEDS AND THE LEAVES OF LAWSONIA INERMIS L.
Authors:   Department of Botany, Nirmala College for Women, Coimbatore, Tamil Nadu, India., Nimya K.P , Arul Sheeba Rani M ,   Department of Botany, Nirmala College for Women, Coimbatore, Tamil Nadu, India., Marclin Joe Felix D ,   Department of Botany, Nirmala College for Women, Coimbatore, Tamil Nadu, India.
Published: May 2022

The antioxidant potential of different fractions of ethanol extracts of seeds of Bixa orellana L. (Bixaceae) and ethanolic extracts of leaves of Lawsonia inermis L. were investigated via 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity using ascorbic acid (Vitamin C) as a standard reference. The free radical scavenging activity of annatto extract ranged from 14.40% to 77.95% in Bixa orellana and 16.50% to 71.8 % in Lawsonia inermis relative to ascorbic acid (15% to 86%) at respective concentration between 10µm/ml and 50µm/ml. phytochemical analysis shows the presence of secondary metabolites such as alkaloids, saponin, tannin, terpenoids and phenolic groups. Hence, both the samples have potential source of new natural antioxidant. Another aim of this study is that the people to get the natural dyes instead of synthetic dye. Natural dyes are not only eco-friendly but also protect human skin. These two samples have both dyeing property and medicinal properties.
Concentration of alpha-defensins in the blood plasma of children with Helicobacter pylori – associated peptic ulcer of the duodenum
Authors:   Department of Pediatrics and Medical Genetics Bukovinian State Medical University, Chernivtsi, Ukraine, Sorokman Tamila V , Moldovan Pavlo M. ,   Department of Pediatrics and Medical Genetics Bukovinian State Medical University, Chernivtsi, Ukraine, Sokolnyk Iryna S. ,   Department of Pediatrics and Medical Genetics Bukovinian State Medical University, Chernivtsi, Ukraine, Koliesnik Dmytro I. ,   Department of Pediatrics and Medical Genetics Bukovinian State Medical University, Chernivtsi, Ukraine, Popelyuk Natalia O. ,   Department of Pediatrics, Neonatology and Perinatal Medicine of Bukovinian State Medical University, Chernivtsi, Ukraine
Published: May 2022

Introduction. Various gastrointestinal and extragastric diseases are associated with H. pylori in children and adolescents, but the strongest testing and treatment guidelines are only for children and adolescents with peptic ulcer. The most promising developments now are the study of the antibacterial effect of endogenous antimicrobial peptides (AP), among which the most important are defenses 1-3 (human neutrophil peptides, HNPs1-3). Objective. To investigate the concentration of HNPs 1-3 in children with H. pylori-associated peptic ulcer of the duodenum (DU). Methods. A study of 65 children with DU (47 children with H. pylori-associated DU, 18 children with H. pylori-negative DU) and 25 healthy children aged 7-18 years with the determination of HNPs 1-3 levels in plasma. Results. More common was H. pylori in the group of children with III grade of inflammation than in the group of children with II grade (χ2:p<0.0001). A significant association was found between mucosal inflammation activity and the presence of H. pylori (r=0.66, p<0.0001). The mean level of HNP1-3 in healthy children was 13.67±0.96 ng/ml, in children with DU it was probably higher and was 104.88±11.5 ng/ml (p=0.005). There is a direct correlation between the level of HNP1-3 and the severity of DU in children (r=0.67, p>0.05), as well as between HNP1-3 and the activity of the inflammatory process (r=0.73, p>0.01). In children with H. pylori-associated DU, HNP1-3 values were significantly higher (107.34±16.18 [98.45-119.22]) ng/ml than those in children with DU not associated with H. pylori infection (66.70±11.31 [59.54-73.29]) ng/ml and in healthy children (13.67±0.96 [7.27-18.91] ng/ml). Conclusion. Elevated plasma HNP1-3 levels in children with DU in the presence of H. pylori are likely to be a protective response to limit infection that can be used as a potential biomarker of adverse events.
Parvovirus infection in fetal life. Case report and recent literature updates
Authors:   Filantropia Clinical Hospital, Bucharest, Romania, Nitica Ruxandra-Patricia , Gica Nicolae ,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania,   Filantropia Clinical Hospital, Bucharest, Romania, Botezatu Radu ,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania,   Filantropia Clinical Hospital, Bucharest, Romania, Peltecu Gheorghe ,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania,   Filantropia Clinical Hospital, Bucharest, Romania, Panaitescu Anca Maria ,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania,   Filantropia Clinical Hospital, Bucharest, Romania
Published: May 2022

Background. The parvovirus B19 (B19V) belongs to the Parvoviridae family, genus Erythrovirus, and is a virus that causes a common childhood disease called erythema infectiosum, also largely known as the fifth childhood disease. The clinical appearance is marked by the “slapped cheek” facies and an erythematous rash localized mainly on the extremities and on the trunk. Most people gain immunity during childhood, and when it occurs in pregnancy in non-immunized women, there are some serious complications for the fetus that can occur. B19V infection in pregnancy can conduct to fetal loss or severe hydrops fetalis, due to the risk of vertical transmission to the fetus and the virus tropism for the erythropoietic fetal stem cells with subsequent cell destruction and fetal anemia. Invasive treatment, as intrauterine fetal transfusion, is necessary for the cases of severe fetal anemia with good survival rates afterwards. The purpose of this review is to update the current knowledge regarding the best management of severe fetal anemia and other complications related to B19V infection in pregnancy, based on the latest data from literature and guidelines. Methods. Electronic research for relevant articles published in the last years was made, with the usage of PubMed, Medline, Cochrane Data Base, and the current international guidelines promoted by the Obstetrics and Gynecology Societies. Results and conclusions. The importance of prenatal detection of non-immunized women by serologic testing for parvovirus B19 should not be overlooked, and subsequent follow-up should be recommended in order to lower the incidence of fetal complications associated with developing the disease in pregnancy, especially during epidemics. In case of P19V infection in pregnancy, serial ultrasounds and lab tests should be performed in order to determine the impact on the fetus and the apparition of fetal hydrops. The future moms who are not immunized to B19V should be advised about the risk of vertical transmission and the associated fetal sequelae that can occur. Assessment for maternal disease and for fetal impairment has to become a priority when there are signs of primary infection in pregnancy.
Cardiovascular involvement in Pediatric multisystemic inflammatory syndrome temporally associated with COVID-19 infection
Authors:   “George Emil Palade” University of Medicine, Pharmacy, Science and Technology, Emergency Institute of Cardiovascular Diseases and Transplantation, Clinic of Pediatric Cardiology, Targu-Mures, Romania, Muntean Iolanda , Hagau Asmaa Carla ,   Emergency Institute of Cardiovascular Diseases and Transplantation, Clinic of Pediatric Cardiology, Targu-Mures, Romania, Fagarasan Amalia ,   “George Emil Palade” University of Medicine, Pharmacy, Science and Technology, Emergency Institute of Cardiovascular Diseases and Transplantation, Clinic of Pediatric Cardiology, Targu-Mures, Romania, Suteu Carmen ,   Emergency Institute of Cardiovascular Diseases and Transplantation, Clinic of Pediatric Cardiology, Targu-Mures, Romania
Published: May 2022

In 2020, World Health Organization declared the infection with COVID-19 a pandemic. Even though the risk of infestation and mortality is lower in children than in adults, children are more prone to develop a hyperimmune state after COVID-19 infection called pediatric multi-system inflammatory syndrome or PIMS. In PIMS, cardiovascular involvement with myocardial injury is present in most patients. Due to the novelty of this pathology, little is known about the implication on the cardiovascular system. This review focuses on the most recent data published on the pediatric multi-system inflammatory syndrome associated with COVID-19 infection, pathophysiological mechanisms, and especially cardiovascular involvement. Furthermore, it emphasizes the role of pediatric cardiologists in its management.
Use of phytotherapy in pediatric respiratory diseases
Authors:   Sc Fito Clinic Dr M SRL Timisoara, Romania, Munteanu Cristina
Published: May 2022

Herbal medicine is a mild and well-tolerated alternative treatment method that could be used to treat pediatric respiratory ailments. Medicinal plants such as captalan, geranium, turmeric or echinacea have been shown in numerous studies to have the ability to significantly improve the respiratory function of pediatric patients and may thus be a viable alternative to conventional treatments in acute and chronic respiratory diseases.
Genetic variation in phenylketonuria: analysis of the PAHvdb database
Authors:   Faculty of Medicine and Farmacy, University of Oradea, Romania, Iuhas Alin Remus ,   Pediatrics II, Emergency Clinical County Hospital, Oradea, Romania, Jurca Claudia ,   Faculty of Medicine and Farmacy, University of Oradea, Romania,   Bihor Regional Center for Medical Genetics, Emergency Clinical County Hospital, Oradea, Romania, Bembea Marius ,   Faculty of Medicine and Farmacy, University of Oradea, Romania,   Bihor Regional Center for Medical Genetics, Emergency Clinical County Hospital, Oradea, Romania
Published: May 2022

Introduction. Phenylketonuria (PKU) is the most frequent inborn metabolism error. The principal determinant factor for the metabolic phenotype in PKU is the residual enzymatic activity, which is determined by the variations in the phenylalanine hydroxylase (PAH) gene. To date, there are known over 1200 PAH gene variants contained in the PAH International Database of Variations in Phenylalanine Hydroxylase Gene (PAHvdb). Aim. The aim of this study is to elaborate an updated PAH variant report with their type, localization, frequency and severity. Material and method. The PAH variant analysis was made using PAHvdb. PAHvdb presently contains 1285 PAH variants and is connected to BIOPKU genotype-phenotype database which has anonymized information from nearly 18000 PKU patients, with data regarding the genotype and the correspondent phenotype. Results. From the 1285 studied variants, the most frequent variants are substitutions – 1051 (81.8%) and deletions – 150 (11.7 %). The majority (723 - 56.3%) is represented by missense mutations, followed in frequency by frameshift variants - 177 (13.8%), splice ESS (Exonic Splicing Silencer) variants - 127 (9.9%) and nonsense mutations - 86 (6.7%). The most affected region of the gene is exon 6 (169 variants), followed by exon 7 (151 variants), exon 3 (130 variants) and exon 11 (121 variants). The majority of variants are located in the catalytic (57.66%) domain. The most frequent 3 alleles are c.1222C>T with a frequency of 19,2%, c.1066-11G>A with a frequency of 6,8% and c.782G>A with a frequency of 5.5%. From the total 1285 variants, 488 (38.5%) cause a severe phenotype, 57 (4.9%) cause a moderate phenotype and 74 (6%) cause a mild phenotype; in the case of 666 variants (50,6%) which have a low allelic frequency the metabolic phenotype couldn’t be established. Discussions. The majority of the variants are substitutions, missense in the catalytic domain of the gene, on the 6th exon. Approximatively 50% of the alleles are found in single patients so they can’t be used for phenotypic prediction. The majority of variants are causing a severe phenotype. Conclusion. The existence of a database with a large number of PKU patients and PAH variants brings an important contribution to the understanding of the genotype-phenotype relation and to the capacity of better phenotypical prediction based on genotype.
Literature review of Radiofrequency Echographic Multi-Spectrometry (REMS) in the diagnosis of osteoporosis and bone fragility
Authors:   “Dr. Ion Cantacuzino“ Clinical Hospital, Bucharest, Romania, Badea Ionut-Andrei ,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Bojinca Mihai ,   “Dr. Ion Cantacuzino“ Clinical Hospital, Bucharest, Romania,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Milicescu Mihaela ,   “Dr. Ion Cantacuzino“ Clinical Hospital, Bucharest, Romania,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Vutcanu Oana ,   “Dr. Ion Cantacuzino“ Clinical Hospital, Bucharest, Romania, Ilina Andreea-Ruxandra ,   Colentina Clinical Hospital, Bucharest, Romania
Published: May 2022

Background. Osteoporosis is a frequent comorbidity among patients with inflammatory rheumatic diseases, due to the impact of their therapies, the high systemic inflammation and the large-scale use of glucocorticoid treatment. Use of DXA and REMS. Dual X-ray Absorptiometry (DXA) is the “gold standard” for detecting patients with low bone mineral density (BMD), using Z and T scores to define the thresholds for diagnosis of osteopenia and osteoporosis, but this method has proven many disadvantages in time, especially in patients with inflammatory rheumatic diseases, those diagnosed with a disease in the spectrum of spondyloarthritides. Therefore, in the last years, a new method of evaluating bone mineral density (BMD) was developed and benefited from numerous efficiency studies: REMS (Radiofrequency Echographic Multi-Spectrometry). The basis of the method is its ability to identify and analyze native unfiltered ultrasound waves that reflect from the bone surface of the vertebra and femoral neck, the so-called echographic radiofrequency (RF) waves. The analysis of all RF waves spectra allows both a quantitative as well as a qualitative assessment of the bone, thus effectively obtaining estimates of bone resistance and evaluating fracture risk through indirect analysis of bone architecture. Conclusions. The studies concluded that REMS is a method at least as good as DXA in detecting patients with osteoporosis by applying the definitions of the World Health Organization (WHO), and also discovered many advantages of the REMS method, probably the biggest advantages being the ability of this ultrasound method of evaluating bone fragility independent of BMD by introducing the Fragility Score (FS) and the possibility of using the ultrasound method in identifying bone demineralization and fragility in pregnant women. Furthermore, numerous studies begin to recognize the usefulness of REMS in diagnosis and evolution of patients with osteoporosis and inflammatory rheumatic diseases. Discussions. A new concept that should be considered is the fact that REMS could potentially more accurately evaluate BMD and bone fragility through the FS in patients with diseases from the spectrum of spondyloarthritides(especially those with ankylosing spondylitis and psoriatic arthritis).
Influences in degenerative joint pathology
Authors:   Department of Family Medicine, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Stanescu Ana Maria Alexandra , Donici Marius ,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Grajdeanu Ioana Veronica ,   Department of Family Medicine, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Simionescu Anca Angela ,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
Published: May 2022

Improving the aged population’s health is a complex goal that requires a multifactorial approach and the knowledge of etiopathogenic factors. Osteoarthritis is the most common joint disease and the second leading cause of disability in people over the age of 50, which has a substantial economic impact and turns into a real social and public health problem. Although it manifested in less than 30% of the older population, pathological changes in the articular cartilage are founded in all deaths over 65 years. That is why we consider primary prophylaxis an important goal for the disease. This minireview presents etiological factors as genetic predisposition, age, body mass index, sex, bone density and the pathogenic degradation of articular cartilage. This includes two aspects of evolution, the progressive degradation of the articular cartilage and the reparative reaction of the subchondral bone. In conclusion, knowing these mechanisms are the first step in managing degenerative joint pathology.
Macrophage Activated Syndrome associated with Adult Onset Still Disease
Authors:   “Dr. Ion Stoia” Clinical Center of Rheumatic Diseases, Bucharest, Romania, Agache Mihaela ,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Mogosan Corina ,   “Dr. Ion Stoia” Clinical Center of Rheumatic Diseases, Bucharest, Romania,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Popescu Claudiu ,   “Dr. Ion Stoia” Clinical Center of Rheumatic Diseases, Bucharest, Romania,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Gabriel Stefan ,   “Carol Davila” Clinical Nephrology Hospital, Bucharest, Romania, Codreanu Catalin ,   “Dr. Ion Stoia” Clinical Center of Rheumatic Diseases, Bucharest, Romania,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
Published: May 2022

Haemophagocytic lymphohistiocytosis (HLH) is an underrecognized hyperinflammatory condition with a high mortality, characterized by inappropriate survival of histiocytes and cytotoxic T cells (CTLs), leading to a cytokine storm, haemophagocytosis and multi-organ damage (1). The currently accepted terminology includes two forms of HLH: the primary or familial HLH (fHLH) and the secondary HLH (sHLH) (2). The sHLH associated with rheumatic conditions is known as macrophage activation syndrome (MAS). MAS can develop at any time during the evolution of the rheumatic diseases: at the beginning, during flare of the disease or during intercurrent infections – mostly with viral trigger. We present a case of MAS in an patient with adult-onset Still Disease. It is of great importance to be recognized in early stages, because if promptly treated it might respond well to combination therapy of glucocorticoids and IL1- blockers.
Comparative study regarding the evaluation of facial aesthetics using the classical and computerized method
Authors:   “George Emil Palade” University of Medicine and Pharmacy, Tg. Mures, Romania, Hack Marius , Hack Ludmila ,   CMI Hack Marius MD, Tg. Mures, Romania, Chibelean Manuela ,   Discipline of Orthodontics, Faculty of Dentistry, “George Emil Palade” University of Medicine and Pharmacy, Tg. Mures, Romania, Zalana Alexandru ,   “George Emil Palade” University of Medicine and Pharmacy, Tg. Mures, Romania, Bud Eugen ,   Discipline of Orthodontics, Faculty of Dentistry, “George Emil Palade” University of Medicine and Pharmacy, Tg. Mures, Romania, Pacurar Mariana ,   Discipline of Orthodontics, Faculty of Dentistry, “George Emil Palade” University of Medicine and Pharmacy, Tg. Mures, Romania
Published: May 2022

Tempting and disturbing by its purpose to correct dental malocclusions, but also asymmetries facial expressions, to shape smiles and to improve the quality of life, orthodontics has experienced a permanent dynamics in recent decades both by improving the means of diagnosis (digitization) as well as the introduction of increasingly high-performance materials: hybrid springs, mini-implants etc. An important diagnostic element in Orthodontics is photography made from the front and profile, which is also a forensic document, on which a series of angular and linear parameters are analyzed at the beginning and end of the treatment. Orthodontic diagnostic pictures are a non-invasive method of diagnosis and are made in the natural position of the head NHP, which is a standardized, reproducible position of the head in space where the subject is looking at a distant point of the eye level. The angular and metric values on the photo or teleradiography of the face/profile are essential elements in both establishing a diagnosis and the treatment plan that will aim to achieve a balanced face and a harmonious profile. These values can be transferred to the computer, and with the help of specialized software will be analyzed and interpreted for each clinical case. This study aimed to perform a comparative analysis of four angles that define the facial profile in a group of 30 patients (15 females and 15 males) patients aged 18-24 years with Angle I class malocclusions and bone growth finished. The values were measured on the profile photograph (after tracing the anthropometric points with an eye pencil) and statistically evaluated for both sexes, and the photos were scanned and important in the DSD software so that the same angles can be evaluated digitally. Digital orthodontics tends to take up more and more space in the assessment of an orthodontic case. In orthodontic treatments, the thickness of the soft parts that can compensate for an unsightly profile of the bone relief is taken into account.