bluuebunny/crossref_metadata_2025 huggingface dataset:
A Biomechanical Comparison of Three Different Lateral Tibia Locking Plates
Authors: Lindeque Bennie , Baldini Todd
Published: January 2010

The purpose of this study was to determine how well laterally placed modern tibia locking plates used in the treatment of Schatzker V tibial plateau fractures would uphold the medial plateau during axial loading. Fifteen third generation Sawbone tibias were obtained and an osteotomy was cut beneath the medial plateau to recreate Schatzker V type plateau fractures. Three groups were created (n=5 per group). Each group was plated with either a Synthes 4.5-mm LCP proximal tibial plate, a Zimmer NCB proximal tibia plate, or a DePuy Polyax tibial plate. A vertical load was applied over the medial plateau using an Instron servohydraulic test machine. Load measurements were analyzed at 2 and 3 mm of subsidence as well as load to failure. Failure was defined as closure of the wedge osteotomy or the medial condyle collapsing. A statistical difference was noted between the 2 plates from Synthes and DePuy and the plate from Zimmer with load carried at 2 and 3 mm of subsidence (Synthes 640.4 N & 943.7 N, Depuy 607.4 N & 891.0 N, Zimmer 459.7 N & 643.2 N). At failure, DePuy (2051.2 N) was statistically stronger than both Synthes (1724.8 N) and Zimmer (1724.8 N). The Synthes and DePuy plates both held up better than the Zimmer plate at 2 and 3 mm of subsidence. Despite this fact, all plates tested held up well above physiological forces of full and partial weight bearing and therefore would be appropriate for the treatment of Schatzker V type tibial plateau fractures.
Insertional Footprint Anatomy of the Pectoralis Major Tendon
Authors: Carey Paul , Owens Brett D.
Published: January 2010

Correct anatomical repair of pectoralis major tendon injuries requires accurate identification of the humeral insertion site. In the absence of residual fibers at the insertion, proper placement requires knowledge of the anatomic relationships in the proximal humerus. This anatomic study attempts to measure these relationships and the dimensions of the insertional footprint to assist in surgical repair and reconstruction. Six matched pairs of cadaver proximal humeri were examined. All specimens were found to be in good condition and none were excluded. The proximal to distal length and maximum width of the pectoralis major tendon were measured at the humeral insertion with a digital caliper. The distance from the superomedial corner of the greater tuberosity to the superior aspect of the tendon insertion was also measured. The mean proximal to distal dimension of the pectoralis major insertion was 72.3±12.3 mm. The mean maximal thickness at the humeral insertion was 1.4±.2 mm. The distance from the superomedial corner of the greater tuberosity to the bony tendon insertion was 42.2±8.5 mm. The anatomic location of the humeral insertion of the pectoralis major tendon can be located in repair of pectoralis tendon injuries by referencing the superomedial corner of the greater tuberosity and the lateral lip of the bicipital groove. Findings in the present study will improve knowledge of the surgical anatomy relevant to repair and reconstruction of the pectoralis major tendon.
Balloon Kyphoplasty in the Treatment of Osteoporotic Vertebral Compression Fracture Nonunion
Authors: Yang Huilin , Wang Genlin , Liu Jiayong , Ebraheim Nabil A. , Niu Guoqi , Hiltner Laura , Lee Alan H. , Tang Tiansi
Published: January 2010

Patients with nonunion of osteoporotic vertebral compression fractures that are refractory to conservative treatments have persistent back pain, progressive vertebral body collapse and kyphosis, and mobility of the fracture. Although many previous reports have reported vertebral compression fractures treated by balloon kyphoplasty, few data is available on using this method to treat nonunion of vertebral compression fractures. This study evaluated the therapeutic potential of balloon kyphoplasty in the treatment of nonunion of osteoporotic vertebral compression fractures. Twenty-one patients with nonunion of osteoporotic vertebral compression fractures were treated with balloon kyphoplasty. The criteria for diagnosis of nonunion osteoporotic vertebral compression fractures included the following: (1) history of pain for at least 6 months at the fracture site; (2) low T1- and high T2-signal on magnetic resonance images; (3) widening of fracture line on routine radiographs; and (4) movement of the endplate and changes of anterior vertebral heights on hyperextension radiographs. All patients were followed for 9 to 33 months postoperatively (mean 25 months). Statistically significant improvements in the mean postoperative anterior and middle vertebral body heights were observed compared with preoperative values. There was also statistically significant improvement in the mean values for Cobb's angle, pain (visual analog scale), and the Oswestry Disability Index at the postoperative assessment compared with the preoperative assessment. No statistically significant differences were noted between the postoperative and final follow-up assessment in any of the evaluated efficacy measures. The study suggests that balloon kyphoplasty is an effective technique to treat nonunion of osteoporotic vertebral compression fractures.
Role-Playing in Nursing Theory: Engaging Online Students
Authors: Levitt Cheryle , Adelman Deborah S.
Published: January 2010

The teaching and learning of nursing theory, at all program levels, is challenging due to the complexity and abstract nature of its content, the dry nature in which the study of theory often is approached, a perception of disconnect from practice, and faculty discomfort and avoidance of the subject matter. Adapting creative educational strategies to the online environment is an ongoing challenge for educators. Role-play relates well to the constructivist basis of creating personal meaning based on the individual's experiences. This article examines the use of role-play as an educational strategy for teaching nursing theory in an online baccalaureate program. In a core professional issues course, students adopt the persona of a specific nursing theorist, interacting with other “nursing theorists” played by their peers. Student engagement and active learning reflect excitement and interest, and course evaluations have been extremely positive for this content and method.
Acquired Pediatric Blepharoptosis Related to Linear Scleroderma
Authors: Kao Tina Y. , Yoon Michael K. , Hwang Thomas N. , Bloomer Michele M. , McCulley Timothy J.
Published: January 2010

Periocular linear scleroderma coup de sabre has been seen in association with blepharoptosis. The authors describe a 4-year-old girl who developed left blepharoptosis simultaneously with a remote scalp lesion consistent with linear scleroderma coup de sabre. This case is unique in that the scalp lesion was distant from the affected eye.
Unilateral Congenital Eyelid Eversion Causing Marked Chemosis in a Newborn
Authors: Shinder Roman , Langer Paul D.
Published: January 2010

A generally healthy male infant was born with unilateral congenital eversion of the upper eyelid causing considerable conjunctival injection and chemosis. Conservative medical management with topical lubrication and antibiotics resolved the condition within a few days.
Curvature of Synthetic and Natural Surfaces Is an Important Target Feature in Classical Pathway Complement Activation
Authors: Pedersen Martin Bjerregård , Zhou Xingfei , Larsen Esben Kjær Unmack , Sørensen Uffe Skov , Kjems Jørgen , Nygaard Jens Vinge , Nyengaard Jens Randel , Meyer Rikke Louise , Boesen Thomas , Vorup-Jensen Thomas
Published: January 2010

The binding of Abs to microbial surfaces followed by complement activation constitutes an important line of defense against infections. In this study, we have investigated the relationship between complement activation and the binding of human IgM Abs to surfaces with different curvatures. IgM Abs to dextran were shown to activate complement potently on dextran-coated particles having a diameter around 250 nm, whereas larger (600 nm) particles were less potent activators. This selectivity regarding particle dimension was also found for complement activation by colloidal substances of microbial origin. Peptidoglycan (PGN) is the major chemical component in the cell wall of Gram-positive bacteria. Fragments of purified PGN with sizes of ∼100 nm promoted complement activation effectively through the classical pathway. By contrast, larger or smaller fragments of PGN did not activate complement strongly. A careful analysis of PGN fragments released during planctonic growth of Staphylococcus aureus showed that these include curvatures that would permit strong IgM-mediated complement activation, whereas the curvature of intact cells would be less effective for such activation. Consistently, we found that the suspended PGN fragments were strong activators of complement through the classical pathway. We suggest that these fragments act as decoy targets for complement activation, providing protection for S. aureus against the host immune response to infection.
Charge‐Transporting Polymers based on Phenylbenzoimidazole Moieties
Authors: Debeaux Marc , Thesen Manuel W. , Schneidenbach Daniel , Hopf Henning , Janietz Silvia , Krüger Hartmut , Wedel Armin , Kowalsky Wolfgang , Johannes Hans‐Hermann
Published: January 2010

A series of novel styrene functionalized monomers with phenylbenzo[d]imidazole units and the corresponding homopolymers are prepared. These side‐chain polymers show high glass‐transition temperatures that even exceed the corresponding value for the common electron‐transporting material 1,3,5‐tris(1‐phenyl‐1H‐benzo[d]imidazol‐2‐yl)benzene (TPBI). Similar electronic behavior between the polymers and TPBI is shown. The polymers are used as matrices for phosphorescent dopants. The fabricated devices exhibit current efficiencies up to 38.5 cd A−1 at 100 cd m−2 and maximum luminances of 7400 cd m−2 at 10 V with a minimum turn‐on voltage as low as 2.70 V in single‐layer devices with an ITO/PEDOT:PSS anode (ITO = indium tin oxide, PEDOT:PSS = poly(3,4‐ethylenedioxythiophene) doped with poly(styrenesulfonate)) and a CsF/Ca/Ag cathode.
Highly Extensible Bio‐Nanocomposite Films with Direction‐Dependent Properties
Authors: Gaharwar Akhilesh K. , Schexnailder Patrick , Kaul Vikas , Akkus Ozan , Zakharov Dmitri , Seifert Soenke , Schmidt Gudrun
Published: January 2010

The structure and mechanical properties of bio‐nanocomposite films made from poly(ethylene oxide) (PEO) that is physically cross‐linked with silicate nanoparticles, Laponite, are investigated. Direction‐dependent mechanical properties of the films are presented, and the effect of shear orientation during sample preparation on tensile strength and elongation is assessed. Repeated mechanical deformation results in highly extensible materials with preferred orientation and structuring at the nano‐ and micrometer scales. Additionally, in vitro biocompatibility data are reported, and NIH 3T3 fibroblasts are observed to readily adhere and proliferate on silicate cross‐linked PEO while maintaining high cell viability.
Orientation Control of Linear‐Shaped Molecules in Vacuum‐Deposited Organic Amorphous Films and Its Effect on Carrier Mobilities
Authors: Yokoyama Daisuke , Setoguchi Yousuke , Sakaguchi Akio , Suzuki Michio , Adachi Chihaya
Published: January 2010

The molecular orientation of linear‐shaped molecules in organic amorphous films is demonstrated to be controllable by the substrate temperature. It is also shown that the molecular orientation affects the charge‐transport characteristics of the films. Although linear‐shaped 4,4′‐bis[(N‐carbazole)styryl]biphenyl molecules deposited on substrates at room temperature are horizontally oriented in amorphous films, their orientation when deposited on heated substrates with smooth surfaces becomes more random as the substrate temperature increases, even at temperatures under the glass transition temperature. Another factor dominating the orientation of the molecules deposited on heated substrates is the surface roughness of the substrate. Lower carrier mobilities are observed in films composed of randomly oriented molecules, demonstrating the significant effect of a horizontal molecular orientation on the charge‐transport characteristics of organic amorphous films.
Macromolecular Scaffolding: The Relationship Between Nanoscale Architecture and Function in Multichromophoric Arrays for Organic Electronics
Authors: Palermo Vincenzo , Schwartz Erik , Finlayson Chris E. , Liscio Andrea , Otten Matthijs B. J. , Trapani Sara , Müllen Klaus , Beljonne David , Friend Richard H. , Nolte Roeland J. M. , Rowan Alan E. , Samorì Paolo
Published: January 2010

The optimization of the electronic properties of molecular materials based on optically or electrically active organic building blocks requires a fine‐tuning of their self‐assembly properties at surfaces. Such a fine‐tuning can be obtained on a scale up to 10 nm by mastering principles of supramolecular chemistry, i.e., by using suitably designed molecules interacting via pre‐programmed noncovalent forces. The control and fine‐tuning on a greater length scale is more difficult and challenging. This Research News highlights recent results we obtained on a new class of macromolecules that possess a very rigid backbone and side chains that point away from this backbone. Each side chain contains an organic semiconducting moiety, whose position and electronic interaction with neighboring moieties are dictated by the central macromolecular scaffold. A combined experimental and theoretical approach has made it possible to unravel the physical and chemical properties of this system across multiple length scales. The (opto)electronic properties of the new functional architectures have been explored by constructing prototypes of field‐effect transistors and solar cells, thereby providing direct insight into the relationship between architecture and function.
Impact of renewable fuels standard ethanol mandates on the corn market
Authors: Anderson John D. , Coble Keith H.
Published: January 2010

Since 2002, the Renewable Fuels Standard has established mandated levels of ethanol blending in gasoline. Mandated ethanol use represents an important component of ethanol demand. Thus, the ethanol mandates influence derived demand for corn. This work investigates the potential impact of ethanol mandates on equilibrium corn prices and quantities, focusing on how the mandates influence market participant expectations. Results illustrate that due to the stochastic nature of supply and demand shocks, even a mandate that is technically nonbinding can have a substantial impact on corn prices and quantities through the mandate's impact on the price‐responsiveness of demand from the ethanol sector. [JEL classifications: Q13, Q42, Q48]. © 2010 Wiley Periodicals, Inc.
Econometric evidence of cross‐market effects of generic dairy advertising
Authors: Cakir Metin , Balagtas Joseph V.
Published: January 2010

We estimate a dairy demand system to evaluate generic dairy advertising in the US, 1990–2005. Previous empirical studies of generic dairy advertising focus only on the market of the advertised good, ignoring potential spill‐over and feedback effects. We specify an LA/AIDS model of dairy demand, which allows consistent estimation of cross‐price and cross‐advertising effects across dairy product markets, and is flexible and satisfies the axioms of consumer theory. We use the non‐linear 3SLS estimator to address endogenous prices and serial correlation, and conduct bootstrapping to generate empirical distributions of elasticity estimates. Results suggest that cross‐market effects are economically and statistically important. Thus, econometric dairy demand models that ignore cross‐advertising and cross‐price effects are mis‐specified. Previous work that ignores substitution between fluid milk and cheese overstates producers' returns to generic advertising for either product. © 2010 Wiley Periodicals, Inc.
Trade implications of price discrimination in a domestic market
Authors: Kuga Nobunori , Suzuki Nobuhiro , Kaiser Harry M.
Published: January 2010

This study examines how domestic price discrimination between fluid and manufacturing milk influences dairy trade. Two types of dairy models are used for the study. The first one is a stylized mathematical model which is used to explore the relative trade effects of domestic price discrimination accompanied with revenue pooling mechanism versus border measures in dairy product markets. The second one is a partial equilibrium, multiple‐region model of dairy policy and trade, which is used to see the empirical implication of domestic price discrimination for six major dairy producers.

The analytical results identify the trading status as the key to determine the relative trade effects. While domestic price discrimination is always less trade distorting than border measures in a net‐importer case, the relative trade distortiveness depends on the export volume in a net exporter case. The theoretical possibility that domestic price discrimination is more trade distorting than border measures is found when the ratio of dairy export to domestic manufacturing milk consumption is very high. The results also indicate that while the both support measures increase dairy export, domestic price discrimination may place greater economic burden on fluid milk consumers and less economic burden on tax payers than border measures. In addition, the results imply that domestic price discrimination schemes can be effective trade protective measures for Canada, Japan and the United States, where the schemes are currently being implemented. © 2010 Wiley Periodicals, Inc.
Electroanalytical studies on electrically conducting polyaniline:polyethyleneterephthalate composite films
Authors: Khalid Mohd , Mohammad Faiz
Published: January 2010

Polyaniline (PANI):polyethyleneterephthalate (PET) composite was prepared by chemical polymerization of aniline diffused in the PET matrix. Thus prepared composite films were characterized by fourier‐transform infrared spectroscopy and scanning electron microscopy and their electrical properties and the thermo‐oxidative stability was studied by thermogravimetry and differential thermal analysis. The stability in terms of DC electrical conductivity retention was studied in an oxidative environment by two slightly different techniques viz. isothermal and cyclic techniques. DC electrical conductivity of composite films was found to be stable up to 90°C for most of the composites under ambient conditions. The composite films were employed as cathode material in secondary cells containing 1M ZnCl2 solution. The studies were carried out on the charge/discharge cycles under a constant current load 140 mA. The composite films showed similar behavior in electrolyte solution and cell response is reversible. To determine the diffusion coefficient for the chloride ions diffusion into the composite films electrochemically, galvanostatic pulse method was used. The diffusion coefficient was estimated to be ∼ 3.28 × 10−12 cm2 s−1. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2010
Crystallization kinetics of cis‐1,4‐polybutadiene
Authors: Di Lorenzo Maria Laura
Published: January 2010

The isothermal and nonisothermal crystallization kinetics of cis‐1,4‐polybutadiene has been investigated with respect to the content of cis units and the linearity of the main chain. The rate of spherulite growth increases with chain regularity as the presence of branches as well as segments with different configurations slows the crystallization rate. The major parameter that determines the crystallization rate is the presence in the formulation of heterogeneities that favor the formation of primary nuclei and determine an anticipated onset of crystallization. As the activity of the heterogeneous nuclei depends more on the type and number of foreign particle than on any chain parameter, no straightforward information on the influence of the chain structure on the crystallization rate can be derived by mere calorimetric analysis, at least for analyzed samples. It is only with combined analysis by optical microscopy that comprehensive information on the crystallization kinetics of cis‐1,4‐polybutadiene can be derived. The results reported in this contribution point out the importance, in polymer science, of preferring complementary instrumentation and not limiting experimental investigations to a single technique of analysis. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2010
Synthesis and characterization of hetarylazo disperse colorants: Preparation and properties of conventional and microemulsified inks for polyester ink‐jet printing
Authors: Kosolia C. T. , Tsatsaroni E. G.
Published: January 2010

The synthesis and characterization of three hetarylazo disperse colorants are described. These compounds were used for the preparation of conventional inks and/or oil‐in‐water microemulsions (microemulsified dyes). The viscosity, conductivity, surface tension, and pH of these inks were studied over a period of time and discussed with respect to their structure. The particle size and particle size distribution of a representative microemulsion were compared to those of a corresponding conventional ink. The measured properties were compared to the properties of commercially available inks. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2010
Rheological behaviors of PVA/H2O solutions of high‐polymer concentration
Authors: Gao Han‐Wen , Yang Rong‐Jie , He Ji‐Yu , Yang Lei
Published: January 2010

The dynamic viscoelastic properties of poly(vinyl alcohol) (PVA)/H2O solutions with concentrations of 10 to 25 wt % have been characterized by controlled‐stress rheometry at 30°C. Parameters relating to the linear and nonlinear viscoelasticities include complex viscosity (η*), storage modulus (G′), loss tangent (tan δ), relaxation time (λ), thixotropy, and creep. Change curves of η*, G′, tanδ, and λ with frequency (ω) have been obtained for the PVA/H2O solutions. Creep and recovery testing yielded compliance (J′) curves with loading and unloading. Shear stress versus rate profiles of the PVA solutions have been obtained through thixotropic measurements. The PVA concentration has been found to have a profound influence on the rheological properties of the aqueous solutions. Four aqueous solutions of 10, 15, 20, and 25 wt % PVA at 30°C exhibited shear‐thinning and showed different transition behaviors of η* and G′ with frequency, and different degrees of creep under constant stress to recovery with time. The 10 wt % PVA solution was viscous and displayed the lowest η* and G′; the 25 wt % PVA solution was viscoelastic and displayed the highest η* and G′; the 15 and 20 wt % PVA solutions showed η* and G′ values and creep to recovery behaviors intermediate between those of the 10 wt % and 25 wt % PVA solutions. The different rheological properties of these PVA/H2O solutions are considered to correlate with interchain hydrogen bonds and shear‐induced orientation in the solutions. Shearing is able to break the intrachain and interchain hydrogen bonds, and, at the same time, the orientation creates new interchain hydrogen bonding. The reorganization of hydrogen‐bonding mode contributes to the transitions of the macroscopic viscoelasticity with frequency. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2010
Adsorption of nile red by poly(N‐isopropylacrylamide) gels in binary water/tetrahydrofuran mixtures
Authors: Thivaios I. , Bokias G.
Published: January 2010

The adsorption of Nile Red by poly(N‐isopropylacrylamide) (PNIPAM) gels in binary water/tetrahydrofuran solutions was investigated using absorption spectrophotometry as a function of the volume fraction of THF, φ. Due to the cononsolvency abilities of such binary solvent mixtures, deswelling of the PNIPAM gels is observed in water‐rich mixtures, 0 ≤ φ ≤ 0.6, while the gels reswell for φ > 0.6. The position of the absorption band of Nile Red before and after equilibration with the PNIPAM gels indicates that the composition of the external solvent mixture is not practically influenced by the swelling process. On the other hand, it is found that the gels can effectively adsorb Nile Red in water‐rich mixtures (φ < 0.6), whereas no significant adsorption was observed in tetrahydrofuran‐rich mixtures. In fact, about 80% of the dye is adsorbed by the PNIPAM gels, at φ = 0.2. Under these conditions, the rather shrunk PNIPAM gel offers a more convenient less polar environment for Nile Red than the water‐rich bulk solvent. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2010
Geographic distribution of autism in California: A retrospective birth cohort analysis
Authors: Van Meter Karla C. , Christiansen Lasse E. , Delwiche Lora D. , Azari Rahman , Carpenter Tim E. , Hertz‐Picciotto Irva
Published: January 2010

Prenatal environmental exposures are among the risk factors being explored for associations with autism. We applied a new procedure combining multiple scan cluster detection tests to identify geographically defined areas of increased autism incidence. This procedure can serve as a first hypothesis‐generating step aimed at localized environmental exposures, but would not be useful for assessing widely distributed exposures, such as household products, nor for exposures from nonpoint sources, such as traffic.

Geocoded mothers' residences on 2,453,717 California birth records, 1996–2000, were analyzed including 9,900 autism cases recorded in the California Department of Developmental Services (DDS) database through February 2006 which were matched to their corresponding birth records. We analyzed each of the 21 DDS Regional Center (RC) catchment areas separately because of the wide variation in diagnostic practices. Ten clusters of increased autism risk were identified in eight RC regions, and one Potential Cluster in each of two other RC regions.

After determination of clusters, multiple mixed Poisson regression models were fit to assess differences in known demographic autism risk factors between the births within and outside areas of elevated autism incidence, independent of case status.

Adjusted for other covariates, the majority of areas of autism clustering were characterized by high parental education, e.g. relative risks >4 for college‐graduate vs. nonhigh‐school graduate parents. This geographic association possibly occurs because RCs do not actively conduct case finding and parents with lower education are, for various reasons, less likely to successfully seek services.
NMR structure of duplex DNA containing the α‐OH‐PdG·dA base pair: A mutagenic intermediate of acrolein
Authors: Zaliznyak Tanya , Lukin Mark , El‐khateeb Mahmoud , Bonala Rahda , Johnson Francis , de los Santos Carlos
Published: January 2010

Acrolein, a cell metabolic product and main component of cigarette smoke, reacts with DNA generating α‐OH‐PdG lesions, which have the ability to pair with dATP during replication thereby causing G to T transversions. We describe the solution structure of an 11‐mer DNA duplex containing the mutagenic α‐OH‐PdG·dA base pair intermediate, as determined by solution nuclear magnetic resonance (NMR) spectroscopy and retrained molecular dynamics (MD) simulations. The NMR data support a mostly regular right‐handed helix that is only perturbed at its center by the presence of the lesion. Undamaged residues of the duplex are in anti orientation, forming standard Watson‐Crick base pairs alignments. Duplication of proton signals at and near the damaged base pair reveals the presence of two enantiomeric duplexes, thus establishing the exocyclic nature of the lesion. The α‐OH‐PdG adduct assumes a syn conformation pairing to its partner dA base that is protonated at pH 6.6. The three‐dimensional structure obtained by restrained molecular dynamics simulations show hydrogen bond interactions that stabilize α‐OH‐PdG in a syn conformation and across the lesion containing base pair. We discuss the implications of the structures for the mutagenic bypass of acrolein lesions. © 2010 Wiley Periodicals, Inc. Biopolymers 93: 391–401, 2010.

This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at biopolymers@wiley.com
Synthesis of S‐Adenosyl‐L‐homocysteine Capture Compounds for Selective Photoinduced Isolation of Methyltransferases
Authors: Dalhoff Christian , Hüben Michael , Lenz Thomas , Poot Peter , Nordhoff Eckhard , Köster Hubert , Weinhold Elmar
Published: January 2010

Understanding the interplay of different cellular proteins and their substrates is of major interest in the postgenomic era. For this purpose, selective isolation and identification of proteins from complex biological samples is necessary and targeted isolation of enzyme families is a challenging task. Over the last years, methods like activity‐based protein profiling (ABPP) and capture compound mass spectrometry (CCMS) have been developed to reduce the complexity of the proteome by means of protein function in contrast to standard approaches, which utilize differences in physical properties for protein separation. To isolate and identify the subproteome consisting of S‐adenosyl‐L‐methionine (SAM or AdoMet)‐dependent methyltransferases (methylome), we developed and synthesized trifunctional capture compounds containing the chemically stable cofactor product S‐adenosyl‐L‐homocysteine (SAH or AdoHcy) as selectivity function. SAH analogues with amino linkers at the N6 or C8 positions were synthesized and attached to scaffolds containing different photocrosslinking groups for covalent protein modification and biotin for affinity isolation. The utility of these SAH capture compounds for selective photoinduced protein isolation is demonstrated for various methyltransferases (MTases) acting on DNA, RNA and proteins as well as with Escherichia coli cell lysate. In addition, they can be used to determine dissociation constants for MTase–cofactor complexes.
Chemical Synthesis and Biological Screening of 2‐Aminoimidazole‐Based Bacterial and Fungal Antibiofilm Agents
Authors: Rogers Steven A. , Bero Joseph D. , Melander Christian
Published: January 2010

A collection of 2‐aminoimidazole/triazole amides has been synthesized and screened for antibiofilm activity. This class of small molecules was found to modulate the biofilm activity of Pseudomonas aeruginosa, a multidrug‐resistant strain of Acinetobacter baumannii (MDRAB), a methicillin‐resistant Staphylococcus aureus strain (MRSA), Escherichia coli, Rhodospirillum salexigens, Staphylococcus epidermidis, Vibrio vulnificus, and vancomycin‐resistant Enterococcus faecium as well as the yeast Candida albicans and Cryptococcus neoformans. Furthermore, lead compounds were found to not lyse red blood cells at active concentrations.
Mutant Lipase‐Catalyzed Kinetic Resolution of Bulky Phenyl Alkyl sec‐Alcohols: A Thermodynamic Analysis of Enantioselectivity
Authors: Vallin Michaela , Syrén Per‐Olof , Hult Karl
Published: January 2010

The size of the stereoselectivity pocket of Candida antarctica lipase B limits the range of alcohols that can be resolved with this enzyme. These steric constrains have been changed by increasing the size of the pocket by the mutation W104A. The mutated enzyme has good activity and enantioselectivity toward bulky secondary alcohols, such as 1‐phenylalkanols, with alkyl chains up to eight carbon atoms. The S enantiomer was preferred in contrast to the wild‐type enzyme, which has R selectivity. The magnitude of the enantioselectivity changes in an interesting way with the chain length of the alkyl moiety. It is governed by interplay between entropic and enthalpic contributions and substrates with long alkyl chains are resolved best with E values higher than 100. The enantioselectivity increases with temperature for the small substrates, but decreases for the long ones.
ChemInform Abstract: Structural and Molecular Orbital Properties of Some Boroxine Derivatives — A Theoretical Study
Authors: Tuerker Lemi , Guemues Selcuk , Atalar Taner
Published: January 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Natural Monoclinic AgPb(Bi2Sb)3S6, an Sb‐Rich Gustavite.
Authors: Pazout Richard , Dusek Michal
Published: January 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Novel White Afterglow Phosphorescent Phosphor Ca3SnSi2O9: Dy3+.
Authors: Wei Rui‐Ping , Ju Zheng‐Hua , Ma Jing‐Xin , Zhang Dong , Zang Zhi‐Peng , Liu Wei‐Sheng
Published: January 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: AgCrS2: A Spin Driven Ferroelectric.
Authors: Singh K. , Maignan A. , Martin C. , Simon Ch.
Published: January 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Preparation and Characteristic of Spherical Li3V2(PO4)3.
Authors: Wang X. Y. , Yin S. Y. , Zhang K. L. , Zhang Y. X.
Published: January 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Gadolinium‐Bridged Polytungstoarsenate(III) Nanocluster: [Gd8As12W124O432 (H2O)22]60‐.
Authors: Hussain Firasat , Conrad Franziska , Patzke Greta R.
Published: January 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Broensted Acid Mediated Novel Rearrangements of Diarylvinylidenecyclopropanes and Mechanistic Investigations Based on DFT Calculations.
Authors: Li Wei , Shi Min , Li Yuxue
Published: January 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Tetra‐(tetraalkylammonium)octamolybdate Catalysts for Selective Oxidation of Sulfides to Sulfoxides with Hydrogen Peroxide.
Authors: Yang Chuanbo , Jin Qingping , Zhang Hua , Liao Jian , Zhu Jin , Yu Bin , Deng Jingen
Published: January 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Practical Synthesis of Linear α‐Iodo/Bromo‐α,β‐Unsaturated Aldehydes/Ketones from Propargylic Alcohols via Au/Mo Bimetallic Catalysis.
Authors: Ye Longwu , Zhang Liming
Published: January 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Allylic C—H Amination for the Preparation of syn‐1,3‐Amino Alcohol Motifs.
Authors: Rice Grant T. , White M. Christina
Published: January 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Practical Photochemically Induced Method for N—N Bond Cleavage of N,N‐Disubstituted Hydrazides.
Authors: Lebrun Stephane , Couture Axel , Deniau Eric , Grandclaudon Pierre
Published: January 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Catalytic Mannich‐Type Reactions of Sulfonylimidates.
Authors: Matsubara Ryosuke , Berthiol Florian , Nguyen Huy V. , Kobayashi Shu
Published: January 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Directed Manganation of Functionalized Arenes and Heterocycles Using tmp2Mn·2MgCl2·4LiCl.
Authors: Wunderlich Stefan H. , Kienle Marcel , Knochel Paul
Published: January 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Application of Cl3CCONH2/PPh3 Towards the Synthesis of Bioactive Amides.
Authors: Chaysripongkul Skydow , Pluempanupat Wanchai , Jang Doo Ok , Chavasiri Warinthorn
Published: January 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: An Unusual N‐Boc Deprotection of Benzamides under Basic Conditions.
Authors: Yin Biaolin , Zhang Yuanxiu
Published: January 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Gold‐Catalyzed Synthesis of Carbon‐Bridged Medium‐Sized Rings
Authors: Barabe Francis , Betournay Genevieve , Bellavance Gabriel , Barriault Louis
Published: January 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Ni‐Catalyzed Sonogashira Coupling of Nonactivated Alkyl Halides: Orthogonal Functionalization of Alkyl Iodides, Bromides, and Chlorides.
Authors: Vechorkin Oleg , Barmaz Delphine , Proust Valerie , Hu Xile
Published: January 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Direct Trifluoromethylation of Nitriles Promoted by Tetrabutylammonium Bifluoride.
Authors: Huang Adrian , Li Huan‐Qiu , Massefski Walter , Saiah Eddine
Published: January 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Simple Chiral Pyrrolidine—Pyridine‐Based Catalysts for Highly Enantioselective Michael Addition to Nitro Olefins.
Authors: Xu Da‐Zhen , Shi Sen , Wang Yongmei
Published: January 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: The Selective Reduction of Nitroarenes to N‐Arylhydroxylamines Using Zn in a CO2/H2O System.
Authors: Liu Shijuan , Wang Yanhua , Jiang Jingyang , Jin Zilin
Published: January 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Practical Catalytic Asymmetric Synthesis of Diaryl‐, Aryl Heteroaryl‐, and Diheteroarylmethanols.
Authors: Salvi Luca , Kim Jeung Gon , Walsh Patrick J.
Published: January 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Chiral Amide from (1S,2R)‐(+)‐Norephedrine Alkaloid in the Enantioselective Addition of Diethylzinc to Aryl and Heteroaryl Aldehydes.
Authors: Ananthi Nallamuthu , Balakrishnan Umesh , Vinu Ajayan , Ariga Katsuhiko , Velmathi Sivan
Published: January 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Proline—Threonine Dipeptide as an Organocatalyst for the Direct Asymmetric Aldol Reaction.
Authors: Chandrasekhar Srivari , Johny Kancharla , Reddy Chada Raji
Published: January 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Rh‐Catalyzed Reductive Coupling Reaction of Aldehydes with Conjugated Dienes Promoted by Triethylborane.
Authors: Kimura Masanari , Nojiri Daisuke , Fukushima Masahiro , Oi Shuichi , Sonoda Yusuke , Inoue Yoshio
Published: January 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Lanthanum Tricyanide‐Catalyzed Acyl Silane—Ketone Benzoin Additions.
Authors: Tarr James C. , Johnson Jeffrey S.
Published: January 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Homogeneous, Anaerobic (N‐Heterocyclic Carbene)—Pd or —Ni Catalyzed Oxidation of Secondary Alcohols at Mild Temperatures.
Authors: Berini Christophe , Brayton Daniel F. , Mocka Corey , Navarro Oscar
Published: January 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Copper‐Catalyzed N‐Allenylation of Allylic Sulfonamides.
Authors: Persson Andreas K. Aa. , Johnston Eric V. , Baeckvall Jan‐E.
Published: January 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Biaryl and Aryl Ketone Synthesis via Pd‐Catalyzed Decarboxylative Coupling of Carboxylate Salts with Aryl Triflates.
Authors: Goossen Lukas J. , Linder Christophe , Rodriguez Nuria , Lange Paul P.
Published: January 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Enantioselective Pinacol Coupling Reaction of Aromatic Aldehydes Catalyzed by Chiral Vanadium Complexes.
Authors: Sun Jiangtao , Dai Zhenya , Li Changsi , Pan Xu , Zhu Chengjian
Published: January 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Allylic Ethers as Educts for Suzuki—Miyaura Couplings in Water at Room Temperature.
Authors: Nishikata Takashi , Lipshutz Bruce H.
Published: January 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of 2,4,6‐Trisubstituted Naphthalenes via Novel Copper‐Promoted Tandem Coupling and Intramolecular Cyclization.
Authors: Wang Yuguang , Zhu Bingchun , Zhu Qin
Published: January 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of C1‐Symmetric BINOLs Employing N‐Heterocyclic Carbene—Copper Complexes.
Authors: Grandbois Alain , Mayer Marie‐Eve , Bedard Marion , Collins Shawn K. , Michel Typhene
Published: January 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.