bluuebunny/crossref_metadata_2025 huggingface dataset:
Chemical constituents from Ficus sur Forssk (Moraceae)
Authors: Ngoh Misse Mouelle Eitel , Foundikou Nsangou Mohamed , Michiren Mandou Vanini Samiyatou , Wansi Jean Duplex , Akone Sergi Herve , Ngeufa Happi Emmanuel
Published: November 2022

Phytochemical investigation of the aerial roots of Ficus sur, a Cameroonian medicinal plant, resulted in a previously undescribed cerebroside, suroside (1), in addition to its aglycon congener suramide (2). Moreover, six known natural products including alpinumisoflavone (3), wighteone metabolite (4), oleanolic acid (5), β-sitosterol (6), β-sitosterol-3-O-β-D-glucopyranoside (7), and epi-ѱ-taraxastanolone (8) were identified. The structures of the previously undescribed compounds were determined by analysis of 1D and 2D-NMR (One and two dimensional nuclear magnetic resonance), mass spectrometry, chemical conversion, and by comparison of these data with those from the literature. Wighteone metabolite (4) exhibited a weak cytotoxic activity against the human HepG2 hepatocellular carcinoma cells with an IC50 value of 51.9 µM.
Meaningful Comparisons With Ordinal-Scale Items
Authors: Schnuerch Martin , Haaf Julia M. , Sarafoglou Alexandra , Rouder Jeffrey N.
Published: November 2022

Ordinal-scale items—say items that assess agreement with a proposition on an ordinal rating scale from strongly disagree to strongly agree—are exceedingly popular in psychological research. A common research question concerns the comparison of response distributions on ordinal-scale items across conditions. In this context, there is often a lingering question of whether metric-level descriptions of the results and parametric tests are appropriate. We consider a different problem, perhaps one that supersedes the parametric-vs-nonparametric issue: When is it appropriate to reduce the comparison of two (ordinal) distributions to the comparison of simple summary statistics (e.g., measures of location)? In this paper, we provide a Bayesian modeling approach to help researchers perform meaningful comparisons of two response distributions and draw appropriate inferences from ordinal-scale items. We develop four statistical models that represent possible relationships between two distributions: an unconstrained model representing a complex, non-ordinal relationship, a nonparametric stochastic-dominance model, a parametric shift model, and a null model representing equivalence in distribution. We show how these models can be compared in light of data with Bayes factors and illustrate their usefulness with two real-world examples. We also provide a freely available web applet for researchers who wish to adopt the approach.
Implementation of Expert System to Diagnose Pregnancy Disorders using Fuzzy Expert System Method
Authors: Putri Septyana , Alamsyah Alamsyah , Akhlis Isa
Published: November 2022

The process of problem analysis can be carried out by a computer system that has included a knowledge base and a set of rules from an expert, known as an expert system. One of the problems that the expert system can solve is to diagnose pregnancy disorders. This study aims to determine how to design an expert system by adopting a doctor's expertise with the fuzzy expert system method. The data used in this study were 46 data obtained from the medical records from Tugurejo Hospital in Semarang City. The variables used were general symptoms and pregnancy disorders. The result of this research is the implementation of the fuzzy expert system to diagnose pregnancy disorders. The level of system accuracy generated from the scenario of 26 data as training data and 20 data as test data is equal to 95%.
Design of Attendance System for Pemalang Diskominfo Employees Using Design Thinking Method
Authors: Agus Pratama Luthfi Ilham , Budiman Kholiq
Published: November 2022

Employees are an important part of carrying out the obligations of the Communication and Information Office (Kominfo) Pemalang Regency. However, the management of employee data for recording attendance at the Department of Communication and Information of Pemalang Regency is still processed manually, so that the attendance process management is considered ineffective and inefficient. Therefore, it is necessary to create an Employee Presence System that can manage employee attendance data. The goal is to facilitate the process of managing employee attendance data and making attendance data more precise. A data collection method is applied in making the system is an interview. In the interview, consultations and direct questions and answers were conducted with the field supervisor regarding the system requirements to be made. The design of this system uses the design thinking method. The design thinking method is carried out sequentially from one stage to another. There are five stages in the design thinking method: empathy, determination, ideas, prototypes, and testing. From making a system with this method, a design for an employee attendance system is produced that is comfortable to look at and easy to use in all circles.
Multilayer Perceptron Optimization on Imbalanced Data Using SVM-SMOTE and One-Hot Encoding for Credit Card Default Prediction
Authors: Almajid Adi Sakti
Published: November 2022

Credit risk assessment analysis by classifying potential users is an important process to reduce the occurrence of default users. The problems faced from the classification process using real-world datasets are imbalanced data that causes bias-to-majority in model training outcomes. These problems cause the algorithm to only focus on the majority class and ignore the minority class, even though both classes have the same important role. To overcome this problem, a combination of One-hot encoding (OHE) and SVM-Synthetic minority oversampling technique (SVM-SMOTE) techniques are used for the optimization process of the MLP classification algorithm. OHE is used to encode values categorical nominal and SVM-SMOTE for the oversampling. The results of the measurement of the ability of the model generated from the optimized MLP are then compared with the baseline using the AUC score. The data used is the default of credit card client dataset from Taiwan which has 30000 instances. The result of the highest AUC score of the MLP that has gone through optimization is 0.7184, an increase of 0.2179 compared to the baseline.
Alternating mealtimes during pregnancy and weaning triggers behavioral changes in adult offspring
Authors: Kim Mi-Hee , Park Jihyun , Han Dong-Hee , Noh Jong-Yun , Ji Eun-Sang , Lee Sung-Ho , Kim Chang-Ju , Cho Sehyung
Published: November 2022

In brief

Mealtime changes in pregnant mice revealed impaired neurobehavioral development in mouse offspring. This study is the basis for investigating diseases associated with neurobehavioral development of adult offspring of pregnant shift-working women.

Most organisms on Earth have a biological clock, and their physiological processes are regulated by a 1-day cycle. In modern society, several factors can disturb these biological clocks in humans; in particular, individuals working in shifts are exposed to stark environmental changes that interfere with their biological clock. They have a high risk of various diseases. However, there are scarce experimental approaches to address the reproductive and health consequences of shift work in the offspring of exposed individuals. In this study, considering the fact that shift workers usually have their meals during their adjusted working time, we aimed to examine the effects of a 12-h shift with usual mealtime as a plausible night work model on the neurobehavioral development of adult mouse offspring. In these offspring, early exposure to this mealtime shift differentially affected circadian rhythmic variables and total locomotor activity depending on the timing and duration of restrictive feeding. Moreover, neurobehavioral alterations such as declined short-term memory and depressive-like behavior were observed in adulthood. These results have implications for the health concerns of shift-working women and their children.
Interest Rates, the Taylor Rule, the Quantity Equation, and the Phillips Curve
Authors:   University of Stavanger, Norway, Wang Guizhou , Hausken Kjell ,   University of Stavanger, Norway
Published: November 2022

This article combines the Taylor rule, the Friedman’s Quantity Equation, and the Phillips curve to explore how deviations in the inflation rate, real GDP, money supply, money velocity, and the unemployment rate interact with the interest rate. The motivation is to understand which factors impact the interest rate and how. Applying monthly United States data from 1 January 1959 to 31 March 2022, the contribution and findings show that the deviation in the inflation rate, the deviation in the real GDP, the deviation in the money supply, the money velocity, and the deviation in the unemployment rate are positively correlated with the interest rate. Regression analysis shows that the deviation in the inflation rate and the deviation in the real GDP are statistically positive and interact with the interest rate, consistently with Taylor. The interest rate increases with the money supply and the money velocity. Multicollinearity exists between the deviation in the real GDP and the deviation in the unemployment rate. The interest rate increases with the deviation in the unemployment rate, consistently with the Phillips curve. The deviation in the inflation rate, the deviation in the money supply, the money velocity, and the deviation in the unemployment rate are good interest rate indicators. The combination explains the interest rate more realistically than the Taylor rule.
Scientific and Practical Innovations in Restoring Skin Barrier Properties in Children with Atopic Dermatitis
Authors: Murashkin Nikolay N. , Nezhvedilova Roza Y. , Fedorov Dmitri V. , Epishev Roman V. , Ivanov Roman A. , Materikin Alexander I. , Opryatin Leonid A. , Savelova Alena A. , Rusakova Lyudmila L.
Published: November 2022

Atopic dermatitis (AD) is a multifactorial inflammatory skin disease. Its pathogenetic basis is epidermal barrier dysfunction, immune system dysregulation, as well as skin microbiome diversity decrease that occurs due to genetic predisposition. Considering these factors, the skin of patients with AD requires constant care and use of medications with active regenerative properties. The inclusion of anti-inflammatory components in the composition of modern emollients (zinc sulfate and sucralfate) is crucial for restoring the microbiome and immune mechanisms controlling the skin. This article presents data on pathogenetic applicability and clinical efficacy of emollients with anti-inflammatory compounds in patients with AD.
Congenital Ichthyosis: Clinical and Genetic Characteristics of the Disease
Authors: Murashkin Nikolay N. , Avetisyan Karine O. , Ivanov Roman A. , Makarova Svetlana G.
Published: November 2022

Congenital ichthyosis is a group (almost 100 clinical variants) of rare genetic skin diseases caused by pathogenic changes in more than 50 genes. Clinical features of ichthyosis, regardless of its genotype, are dry skin, peeling, hyperkeratosis frequently accompanied with erythroderma. These patients have extremely low quality of life due to changes in appearance, discomfort due to itching and functional limitations (pain during walking, impaired motor skills and functions due to hyperkeratosis foci in functionally relevant areas), as well as impaired functions of various organs and systems in syndromic forms of disease. Patients need daily skin care and systemic medications. By now, there is no definitive treatment for ichthyosis. Diagnostic difficulties in determining the clinical forms of congenital ichthyosis are associated with their clinical heterogeneity and with similarity in external manifestations. Difficulties in differential diagnosis with other dermatoses are particularly crucial in case of syndromic forms of disease. This review presents the modern classification of ichthyoses, provides data on disease clinical and genetic variants, diagnostic algorithms, treatment methods for patients with this severe disease.
From Nowhere to Somewhere
Authors: Strohschein Heather , Smith Margaret , Yates Linda
Published: November 2022

In August 2020, two colleagues and I began an ongoing conversation on music, consent, power, language/jargon, accessibility, and inclusivity. We are not music therapists, but each of us, from our own professional and personal perspectives, is interested in the therapeutic nature of music. One colleague is a community musician in Glasgow, Scotland. She works for Good Vibrations and the Resonate Project which facilitate inclusive musical workshops and experiences. The other colleague is an amateur musician, participant advisor for one of her music groups, and a representative of people with additional support needs. I am an ethnomusicologist who specializes in Javanese and Balinese gamelan outside of Indonesia particularly as they pertain to community music making. We met through playing gamelan and through the Resonate workshops. Our conversations were a doorway for each of us into community music, musical academia, and the musical life of a woman with special needs. In our conversations, the question of accessibility as it is tied to language and power arose several times. In April 2021, we offered an edited video presentation of our conversations at the 2021 Mid- Atlantic Chapter of the Society of Ethnomusicology (MACSEM) virtual conference. In fall 2021, we hosted an event in collaboration with Good Vibrations at which we used our MACSEM video to facilitate an open conversation among academics, community musicians, music therapists, people with additional support needs, and members of the general public. One goal of this work is to provide unheard voices a place to speak. Our submission to Voices is a video reflection on our experiences beginning with our three-person, off-the-cuff conversations that originated over a year ago. Through this video, we will (literally) share our voices with your readership as we discuss our experiences of language, power, and whose voices are heard. We also reflect back on previous conversations by including our collaborative editing of the video itself. During our overall discussions, we came up with the title, “From nowhere to somewhere: Creating to Join a conversation.” This really helped focus our shared idea of what this is all about: three people from different life experiences and opportunities finding ways of speaking together and creating a format to have a voice in this arena.
Probabilistic Robust Multi-Agent Path Finding
Authors: Atzmon Dor , Felner Ariel , Stern Roni
Published: November 2022

In a multi-agent path-finding (MAPF) problem, the task is to find a plan for moving a set of agents from their initial locations to their goals without collisions. Following this plan, however, may not be possible due to unexpected events that delay some of the agents. Guaranteeing that collisions will never occur may be impossible. An important task is to find a plan that is very likely to succeed, even though unexpected delays may occur. We propose an algorithm for finding a plan in which the probability that no collisions will occur is at least a given parameter p (p-robust plan). We show that finding an optimal p-robust plan is significantly more difficult than finding an optimal standard plan. As a practical solution, we propose a greedy algorithm based on the Conflict-Based Search framework. Our experiments show that it finds p-robust plans with cost that is relatively close to the optimal cost of the standard, non-robust plans.
An Improved Algorithm for Optimal Coalition Structure Generation
Authors: Changder Narayan , Aknine Samir , Dutta Animesh
Published: November 2022

The Coalition Structure Generation (CSG) problem is a partitioning of a set of agents into exhaustive and disjoint coalitions to maximize social welfare. This NP-complete problem arises in many practical scenarios. Prominent examples are included in the field of transportation, e-Commerce, distributed sensor networks, and others. The fastest exact algorithm to solve the CSG problem is ODP-IP, which is a hybrid version of two previously established algorithms, namely Improved Dynamic Programming (IDP) and IP. In this paper, we show that the ODP-IP algorithm performs many redundant operations. To improve ODP-IP, we propose a faster abortion mechanism to speed up IP’s search. Our abortion mechanism decides at runtime which of the IP's operations are redundant to skip them. Then, we propose a modified version of IDP (named MIDP) and an improved version of IP (named IIP). Based on these two improved algorithms, we develop a hybrid version (MIDP-IIP) to solve the CSG problem. After a detailed description of the new algorithm MIDP-IIP, an experimental comparison is conducted against ODP-IP. Our analysis shows that MIDP-IIP performs fewer operations than ODP-IP. In addition, MIDP-IIP reduced significantly many problem instances running times (11% to 37 %), and improved drastically some of them.
Improved Heuristics for Multi-Agent Path Finding with Conflict-Based Search: Preliminary Results
Authors: Li Jiaoyang , Boyarski Eli , Felner Ariel , Ma Hang , Koenig Sven
Published: November 2022

Conflict-Based Search (CBS) and its enhancements are among the strongest algorithms for Multi-Agent Pathfinding. Recent work introduced an admissible heuristic to guide the high-level search of CBS. In this work, we prove the limitation of this heuristic, as it is based on cardinal conflicts only. We then introduce two new admissible heuristics by reasoning about the pairwise dependency between agents. Empirically, CBS with both new heuristics significantly improves the success rate over CBS with the recent heuristic and reduces the number of expanded nodes and runtime by up to a factor of 50, yielding a new state-of-the-art CBS-based algorithm.
Symmetry-Breaking Constraints for Grid-Based Multi-Agent Path Finding
Authors: Li Jiaoyang , Harabor Daniel , Stuckey Peter , Ma Hang , Koenig Sven
Published: November 2022

We describe a new way of reasoning about symmetric collisions for Multi-Agent Path Finding (MAPF) on 4-neighbor grids. We also introduce a symmetry-breaking constraint to resolve these conflicts. This specialized technique allows us to identify and eliminate, in a single step, all permutations of two currently assigned but incompatible paths. Each such permutation has exactly the same cost as a current path, and each one results in a new collision between the same two agents. We show that the addition of symmetry-breaking techniques can lead to an exponential reduction in the size of the search space of CBS, a popular framework for MAPF, and report significant improvements in both runtime and success rate versus CBSH and EPEA* – two recent and state-of-the-art MAPF algorithms.
Multi-Agent Path Finding with Continuous Time and Geometric Agents Viewed through Satisfiability Modulo Theories (SMT)
Authors: Surynek Pavel
Published: November 2022

This paper addresses a variant of multi-agent path finding (MAPF) in continuous space and time. We present a new solving approach based on satisfiability modulo theories (SMT) to obtain makespan optimal solutions. The standard MAPF is a task of navigating agents in an undirected graph from given starting vertices to given goal vertices so that agents do not collide with each other in vertices of the graph. In the continuous version (MAPF-R) agents move in an n-dimensional Euclidean space along straight lines that interconnect predefined positions. For simplicity, we work with circular omni-directional agents having constant velocities in the 2D plane. As agents can have different sizes and move smoothly along lines, a non-colliding movement along certain lines with small agents can result in a collision if the same movement is performed with larger agents. Our SMT-based approach for MAPF-R called SMT-CBS-R reformulates the Conflict-based Search (CBS) algorithm in terms of SMT concepts. We suggest lazy generation of decision variables and constraints. Each time a new conflict is discovered, the underlying encoding is extended with new variables and constraints to eliminate the conflict. We compared SMT-CBS-R and adaptations of CBS for the continuous variant of MAPF experimentally.
Measuring the Vulnerability of a Multi-Agent Pathfinding Solution
Authors: Yoeli Rotem , Stern Roni , Atzmon Dor
Published: November 2022

Multi-agent pathfinding is the problem of finding a non-interfering paths for a set of agents, such that if the agents follow these paths then each agent will reach its desired destination. Recent years have shown tremendous advances in this field, with optimal and suboptimal algorithms that are able to plan paths for over 100 agents in reasonable time. However, autonomous mobile agents are prime targets for cyber-security attacks, where an adversary may take control over an agent to disrupt the agents execution of their plan. This threat raises two questions. The first question is how much damage can an agent do if it does not follow its plan. The second question is how can one plan a-priori to be as robust as possible to such cyber-attacks. In this work, We provide an answer to both questions. To compute the maximal amount of damage that an adversary agent can do, we define a corresponding graph search problem and solve this problem with A*. Then, we provide a very simple method to choose a solution that is robust to such damages. We demonstrate both algorithms in simulation over standard multi-agent pathfinding domains.
Zero-Aware Pattern Databases with 1-Bit Compression for Sliding Tile Puzzles
Authors: Clausecker Robert , Reinefeld Alexander
Published: November 2022

A pattern database (PDB) is a pre-computed lookup table storing shortest distances from abstract states to abstract goal states. PDBs are key components in heuristic search as their entries are used to prune paths that cannot lead to an optimal solution. With the sliding-tile puzzle as an exemplary application domain, we present methods to improve the precision and size of PDBs by improving additive pattern databases to zero-aware additive pattern databases (ZPDBs), reducing the compression rate from previously 1.6 bit to 1 bit per entry, generating optimal additive pattern partitionings, and building effective collections of pattern databases. With these enhancements, we achieve an overall 8.59-fold performance gain on the 24-puzzle compared to the previously best set of 6-tile PDBs.
Development and In Vitro Testing of a Novel Universal Transdermal Drug Delivery Platform to Reduce Medication Nonadherence
Authors: G Ramesh , A Zamat , S Vadlamudi , N Liu , P Akuthota
Published: November 2022

Medication nonadherence results in avoidable symptom exacerbations and hospitalization, causing thousands of deaths and billions of dollars in healthcare costs annually. Although pharmacological therapies are present for chronic diseases, lengthy and complicated medication regimens often have high rates of nonadherence. Transdermal drug delivery is a potential method of reducing medication nonadherence as it allows for long-course medication regimens to be simplified to a one-time epidermal patch. We have engineered a transdermal drug delivery system on a customizable platform to longitudinally deliver a wide variety of soluble small-molecule drugs. As a proof of concept, we have chosen to administer long-course corticosteroids for chronic inflammatory disease via epidermal patch. A drug-in-adhesive matrix consisting of the drug, adhesive, solvents, and penetration enhancers, was cured onto a fluoropolymer release liner. The transdermal drug delivery system has an integrated tapering mechanism to avoid end-of-course steroid dependence and can incorporate other small-molecule medications required for cases of polypharmacy. To date, there have been no successful attempts to develop long-term steroid patches for systemic delivery, which may be attributed to issues with patch adhesion and skin irritation over extended periods of time. We have analyzed such challenges and have designed a proof of concept system to overcome these obstacles in order to provide patients with a simple, inexpensive, and effective solution to complicated and long-term treatment regimens.
Ifrania bahhouensis sp. n. a new valvatiform snail (Gastropoda, Hydrobiidae) from Morocco
Authors: Mabrouki Youness , Glöer Peter , Taybi Abdelkhaleq Fouzi
Published: November 2022

The genus Ifrania Glöer, Mabrouki et Taybi 2020 (Hydrobiidae) was recently described from Morocco; its type species is Ifrania zerroukansis Glöer, Mabrouki et Taybi, 2020 found in the Middle Atlas massif, geographically isolated and known for its other endemic molluscs. Ifrania bahhouensis sp. n. is a new valvatiform hydrobiid gastropod from Morocco; it can be distinguished from I. zerroukansis by the morphology of the shell and anatomical criteria. The new species was found in the northern part of Morocco, in the Sebou River basin. The aim of this paper is to describe the new springsnail species.
Winter distribution and migratory strategies of Eurasian Spoonbills (Platalea leucorodia) from the Pannonian breeding population: are they long-distance migrants?
Authors: Pigniczki Csaba
Published: November 2022

In this paper, the wintering characteristics of the Eurasian Spoonbills (Platalea leucorodia) breeding in the Carpathian Basin (Pannonian population) were analysed. The data of 305 wintering Spoonbills marked with colour-rings in Hungary was used. A significant part, 80% of the Spoonbills, wintered in Africa, while 20% spent the winter in Europe and only two birds in the Asian part of western Turkey. The most important wintering sites were in the central part of North Africa (in Algeria, Libya, but mainly Tunisia) and Italy. The tidal area in the Gulf of Gabes in Tunisia was the most important area where a significant proportion, 65% of all wintering Spoonbills, spent the winter. This study provided new evidence of Spoonbills occurring in Saharan wetlands (Chott Tindla in Algeria) in winter. 2% of the resighted Spoonbills were reported from the wetlands of the Sahel in Sudan, Nigeria, Niger, Mali, Mauritania, and Senegal. European winterers were mainly found in Italy and, to a lesser extent, in the Balkans and the Carpathian Basin. The mean distance between the natal colonies and the wintering areas was 1,535 km. Spoonbills migrated in a south-southwestern direction (mean: 213°) to reach their wintering sites. In the Hungarian population, most specimens (94%) were short-distance migrants (wintered north of 22°N), 2% were long-distance migrants, and 4% were residents. However, the proportions of the residents and short-distance migrants are supposed to be overestimated and the proportion of the long-distance migrants is likely to be underestimated due to the lack of observation effort in sub-Saharan Africa. However, based on the winter census data and the proportion of ringed individuals of Hungarian origin in the wintering flocks, I estimated that the lack of observation effort would only slightly modify the result. There were two shifts in migratory strategies on an individual level: a resident Spoonbill became a short-distance migrant, and a short-distance migrant became a long-distance migrant by a following winter. While most of the East Atlantic Spoonbills are long-distance migrants, the results of this study indicate that most birds in the Pannonian population are likely to be rather short-distance migrants. The results of the GPS tracking also confirm that most Pannonian Spoonbills are short-distance migrants and support the main conclusion of this paper.
FAUNA AND MARINE BIRD POPULATION NEAR THE SOUTH KAMCHATKA NATURE PARK COAST IN SUMMER SEASON
Authors:   Kamchatka Branch of Pacific Geographical Institute FEB RAS, Artukhin Yu.B.
Published: November 2022

The study was conducted in June – July 2016 and 2021 on the southeastern coast of Kamchatka. Birds on line transects and on routes along the coastline were taken into account from the side of a small vessel (boat) and on a motor boat. We recorded 32 bird species, mainly alcids (34.4% of the species composition), larids (15.6%) and anatids (12.5%). The density of bird distribution in the water area was 25.5 individuals/km2 on average. In terms of numbers, the tubenoses and alcids (42.9% each) occupied the dominant position on the accounting transects remote from the land, and on the routes close to the shore – larids (61.5%) and alcids (23.0%). The total number of birds within the boundaries of the coastal water area of 1 280 km2 is approximately 40 thousand individuals. The basis of the population (about 60%) consists of eight species nesting in this area, each of which has more than 1 000 individuals (mainly tufted puffins and murres). The remaining 40% are species from other regions (short-tailed shearwaters migrating from the southern hemisphere, northern fulmars nesting on the neighboring territories and phalaropes during postnesting migrations).
THE FIRST EXPERIENCE OF ASSESSING TAXONOMIC DIVERSITY, ABUNDANCE AND BIOMASS OF INVERTEBRATES (SPIDERS AND INSECTS) IN KAMCHATKA IN THE RIVER FLOODPLAIN BACKGROUND BIOTOPES (ON THE EXAMPLE OF THE AVACHA RIVER LOWER REACHES)
Authors:   Kamchatka State Technical University, Lobkov E.G. , Lobkova L.E. ,   Kronotsky State Nature Biosphere Reserve
Published: November 2022

The parameters of the seasonal dynamics of taxonomic diversity, abundance (number) and biomass of invertebrates (insects and spiders) on 10 different in appearance test areas in the background terrestrial biotopes of the floodplain in the interfluve of the Avacha and Pinachevskaya Rivers in 2018 and 2020 were determined. The maximum indicators of invertebrates abundance (from 200 specimens to 1 thousand or more per oblique by entomological net) in different biotopes were observed at different periods, but all of them occured in the period from mid-June to mid-October, usually from mid-July to August. The absolute values are various in different biotopes. The invertebrates biomass usually grows continuously from May to July, peaks in late July or the first half of August and then declines to a minimum by November with the onset of frost and before the first snowfall. The maximum invertebrates biomass per 1 m2 (during the peak value for each biotope) in 2018 was 0.033 – 0.097 g / m2 (0.998 g – 2.9 g per mowing), the average value (n = 10) was 0.049 g / m2. This index was less in 2020. The average value of insect biomass for 2 seasons per conditional 1m2 of the river floodplain in the studied area was about 0.029 g. Insects predominate among invertebrates, but spiders also occupy a significant part: 18% in abundance (number) and 38% in biomass, respectively,according to the results of mowing in 2018.
Management leadership and teamwork of the collaborators of the District Municipality of Guadalupito
Authors: Haro Basilio Manuel Elías , Calvanapón Alva Flor Alicia
Published: November 2022

The purpose of this research work was to determine the relationship between managerial leadership and teamwork of the collaborators of the District Municipality of Guadalupito, 2022. The methodology used in terms of its approach was quantitative, accordingto its purpose, applied and according to its scope, correlational-descriptive, with a non-experimental and cross-sectional design, which included as study population the collaborators of the District Municipality of Guadalupito, whose study sample consisted of 67 of them, to whom the survey and/or questionnaire with 22 items based on the Likert scale was applied as a technique and instrument for data collection. For the validity of the instrument, the judgement of experts in the subject was used, based on Cronbach's Alpha coefficient. Finally, in the results obtained using the SPSS v25 programme, Spearman's Rho coefficient determined a high level of significance (0.005<0.01) and an average positive correlation (r= 0.338**) between the variables studied. Theresearch concludes by accepting the hypothesis put forward, which confirms the relationship between the two variables.
Eco-efficiency measures for the care of the environment in a Judicial District of Peru
Authors: Gutiérrez Ascón Zenaida Mireya , Rojas Lujan Víctor William
Published: November 2022

The objective of this research was to determine the level of application of legal eco-efficiency measures to care for the environment in a Judicial District of Peru, during the period from 2018 to 2021. For this, a quantitative approach was applied, of type applied, with a non-experimental, cross-sectional and correlational design. It had a study sample of 299 judicial workers, chosen through the application of simple random probabilistic sampling, applying a questionnaire on a Likert scale to obtain the results. It was concluded that there is a very significant correlation between the study variables; likewise, it was determined that, in terms of caring for the environment, none of the judicial workers surveyed (0.00%) considers that the correct use of resources such as white paper (bond), electricity and drinking water is always fulfilled, which shows the deficiency in the application of the eco-efficiency regulations.
Remote work and work commitment of the individual life agent in an insurance company
Authors: Escalante Marín Sonia , Diaz Ramírez Irene Katerine
Published: November 2022

The objective of this research was to determine the relationship of remote work in the work commitment of the individual life agent in an insurance company in the city of Trujillo; Quantitative, applied, descriptive research, with a non-experimental design, with a cross-sectional and correlational approach, whose sample population consisted of 75 individual life agents, to whom a survey was applied by sending them a Google forms questionnaire, resulting in the agents of individual life find remote work at a high level with 68% and work commitment also at a high level with 85%; Regarding the level of significance (P value=0.000), it is less than 0.05, for which it is established that remote work is related to the work commitment of the individual agent in an insurance company; Likewise, the Pearson correlation coefficient was determined, obtaining 0.902 as a result, this indicates that the relationship is very strong.
Chemical surface modification of lithium disilicate needles of a silica-based ceramic after HF-etching and ultrasonic bath cleaning: impact on the chemical bonding with silane
Authors: A Poulon-Quintin , F Rouzé l’Alzit , E Ogden , A Large , C Bertrand , M Bartala
Published: November 2022

Recommendations to obtain the best bonding to silica-based ceramics are to prepare its surface by hydrofluoric-acid HF etching and regular application of a silane. This study investigated how the HF-etching followed by ultrasonic water bath cleaning or by an additional phosphoric acid treatment impacts the adhesion properties of a resin (G-CEM LinkForce®) with a lithium disilicate glass-ceramic (IPS Emax Press, Ivoclar Vivadent). Comparison is based on results obtained with HF etching and direct silane application. After HF-etching, a water ultrasonic bath (4 minutes), and a final air drying, the scratch test critical load increases (+ 46%) thanks to chemical bonding. Additional tests are presented including heat treatments (at 85 °C before and after silanization). If HF-etching is followed by phosphoric acid treatment and drying of silane at 85 °C, scratch test critical load increases (+ 42%) due to mechanical bonding. Similar adhesion properties are obtained with two opposite protocols.
Frozen tissue dissociation for single-nucleus RNA-Seq v1
Authors: Mazutis Linas
Published: November 2022

The protocol described here relies on mechanical dissociation of frozen lung tissue (human or mouse), filtering and washing the nuclei suspension in SCC buffer followed by the FACS sorting. The resulting nuclei suspension can be processed on scRNA-Seq platform of choice, 10X Chromium, inDrops or other. The protocol has been validated on frozen human tissues of lung, breast pancreas and kidney as well as frozen mouse tissues of brain, lung, pancreas.
Cell preparation for scRNA-Seq from diluted bodily fluids v2
Authors: Mazutis Linas
Published: November 2022

Efficient isolation of cells from complex bodily fluids is a crucial step for many biological and biomedical applications. Yet, it can become a particularly challenging when only a small fraction of cells is dispersed in a large volume of fluid, e.g. ~ 1000-10000 cells / 10 mL. In such cases a conventional wisdom would suggest the use of canonical 15 or 50 ml tubes and centrifugation forces at 500-800g to pellet the cells. However, hard centrifugation can damage the cells and rupture their membrane, while at lower centrifugation speeds the sedimentation rates are slow and might be insufficient to form a cell pellet. Moreover, intrinsic variability of cells in terms of size (6-20 µm) and density (1.06-1.29g/mL) may reduce the pelleting and recovery yields. When using swinging bucket rotors and large sample volumes (> 5 mL) the sample sedimentation run times can become very long due to the increased sedimentation path length (distance that cells need to travel to reach bottom of the tube). On another hand, in fixed angle rotors the cells will travel only a short distance before hitting the wall of the tube and as a result will migrate down the wall forming a long trail until reaching the bottom of the tube, which will preclude formation of a tight pellet. Overall, when working with fragile cell samples preference should be given to lower centrifugal forces and shorter centrifugation times. These two requirements can be fulfilled by using smaller tubes as the shorter sedimentation path length will shorten the distance that cells need to travel to reach bottom of the tube. Given these considerations this protocol describes the isolation of viable primary cells from diluted suspensions of bodily fluids. The protocol exemplifies the isolation of cells (immune and cancer cells) from cerebrospinal fluid where the concentration of cells is in the order of 0-20 cells / µl.
Çap-boy modelleri için örnek ağaç seçim ölçütlerinin geliştirilmesi
Authors: ÖZÇANKAYA Niyazi , CARUS Serdar
Published: November 2022

Bu çalışmada plan ünitesi kapsamında kullanılacak çap-boy denklemlerinin düzenlenmesi için seçim yöntemi başarısı ve işlem süresi faktörleri gözetilerek en uygun örnek ağaç seçim yöntemlerinin belirlenmesi amaçlanmıştır. Bunun için aynıyaşlı ve saf kızılçam (Pinus brutia Ten.) meşcerelerinden seçilen 47 örnek alanda 1408 örnek ağaç ölçülmüştür. Örnek ağaçların seçimine ilişkin 54 farklı yöntem kurgulanmıştır. Her bir seçim yöntemi regresyon analizleri, başarı ölçüt setleri ve bağıl puanlama metotları ile değerlendirilmiş ve puanlarına göre sıralanmıştır. Seçim yöntemlerinin örnek alanlarda uygulanma süreleri en kısa yol optimizasyonları ve regresyon analizi yöntemleriyle hesaplanmıştır. En başarılı sonucu veren ve aynı zamanda uygulamadaki işlem süreleri en az olan seçim yöntemlerini belirlemek için Pareto optimal yöntem kullanılmıştır. Sonuç olarak, seçim yöntemleri içerisinde en başarılı yöntemin 16 numaralı, uygulama süresi en kısa olanın ise 1 numaralı yöntem olduğu tespit edilmiştir. Her iki faktör de dikkate alındığında ise 07, 14, 15, 16, 51, 08, 43 ve 49 numaralı seçim yöntemlerinin optimal çözüm kümesini oluşturduğu ortaya konulmuştur. İdeal noktaya en yakın çözümün Weise orta ağacı ve ona en yakın konumdaki iki adet ağaçla çalışan 14 numaralı yöntem olduğu belirlenmiştir.
Control signal algorithm of the accelerator pedal providing an effective energy consumption by an electrobus traction gear
Authors: Zhileykin Mikhail M. , Klimov Alexandr V. , Maslennikov Ivan K.
Published: November 2022

BACKGROUND: At the present moment there become more electrobuses in big towns, and the problem of the increasing the their energy efficiency is actual in intertown traffic (that assumes stops and time limitation among stops) because of the limitated on-board capacitors.
AIMS: Development of the control signal algorithm of the accelerator pedal providing an effective energy consumption by an electrobus traction gear.
METHODS: The new method for control signal formation of the accelerator pedal is proposed. It has a feature that provides the system operation traction gear frequency converter in zone of the increased efficiency factor and limits the velocity of control signal level growing when a driver tromps gas.
RESULTS: Analysis of the electrobus operation results in intertown traffic shows, that the aggregate average electric capacity, consumed at electrobus operating equipped with the energy saving systems, is less by 8,2% than at electrobus operating without energy-saving systems at the same conditions. The average efficiency factor of the traction gear frequency converter system of an electrobus equipped with energy-saving systems has been increased by 4.5%. The time of driving on the route of an electrobus equipped with energy saving systems increased by 27 seconds that is an acceptable result. Energy saving in linehaul operation was provided only by an antislip system operation. During the total time driving of the electrobus energy saving was 2.6%.
CONCLUSIONS: A new method for generating a control signal from the side of the accelerator pedal is proposed, which differs in that it ensures the operation of the traction motor frequency converter system in the zone of increased efficiency and limits the rate of increase in the level of the control action when the driver abruptly presses the accelerator pedal.
Technical electrogenerating tools for road facilities: systematics and design specifics
Authors: Lyashenko Yuriy M. , Prudiy Alexey V.
Published: November 2022

BACKGROUND: Currently the Russian Federation Government has a strong focus to roads safety. This is due to the national project Safe High-Quality Roads. One of tools of pedestrian safety in an urban are road bumps. They are need for drivers speed slow.
Contrarily world scientists create alternative sources of electrical energy. It led to tools type as technical electrogenerating devices.
Whereas technical electrogenerating tools have big amount of developments by russian and world scientists. But in modern scientific literature there is no systematic concept about this tools type.
AIMS: The paper purpose is knowledge summary about technical electrogenerating tools and develop their classification.
METHODS: Energy of a moving car is accumulated and converted into electrical energy by devices type. Concept of technical electrogenerating tools is based on convertion of energy pulse of speed bump into electrical energy at the moment of car runover. This energy can be used for electricity supply of road infrastructure (crosswalk lighting, road sign ligtht, powering traffic lights).
RESULTS: The basic classification feature of these tools is device type converting moving car energy into electrical energy: piezoelectric, hydraulic, electromechanical. In turn technical electrogenerating tools with electromechanical converter are classified by criteria: amount of motor, type of transmission mechanism, design of pressing platform and type of generator.
CONCLUSIONS: The developed classification provides to systematize contributions of russian and world scientists designing devices of technical electrogenerating tools.
The choice of design parameters of main and conrod bearings for passenger car engines
Authors: Zlenko Mikhail A. , Terenchenko Alexey S. , Shibaev Ivan S.
Published: November 2022

BACKGROUND: The creation of a new internal combustion engine begins with a preliminary design, during which the architectural design of the engine is born, the main features of its basic components are determined. Bearings (in this case, sliding bearings) are the cornerstones of the design, which create the foundation and form the basis the skeleton of the power train mechanism and, as a result, the image of the future engine. Therefore, the exact selection of these key engine components is an ongoing challenge.
AIMS: Тo develop and propose an engineering method for selecting bearing parameters based on a statistical analysis of the most successful car engine designs implemented in practice.
METHODS: The method of comparative analysis of relative loads was used in the work, which allows to evaluate the loading conditions and the bearing capacity of main and conrod bearings using relative values familiar to engine engineers, such as the ratio of the diameters of the conrod and main journals to the cylinder diameter (d/Dc, d1/Dc), the ratio of the length of the journal to their diameters (Lcp/d, Lmp/d) or to the diameter of the cylinder (Lcp/Dc, Lmp/Dc), etc.
RESULTS: Simple but physically understandable values have been obtained that characterize the operating conditions of the bearing, with the help of which, using the available catalogs of manufacturers, the designer has the opportunity to select the bearing shells closest to his, the designers, requirements i.e., choose the type, size of the bearings and potential supplier.
CONCLUSIONS: The proposed method for selecting the design parameters of automobile engines bearings can significantly reduce the amount of computational work at the stage of preliminary design of the power mechanism (crankshaft-cylinder block-rod-piston group). The data presented in the work can also be useful for updating the long-outdated data presented in the educational literature of the 70s90s.
An Instrumental Case Study Exploring the Accessibility of Synchronous, Virtual Instruction for Adult Learners with Disabilities within a Federal Government Agency
Authors:   , McDaniel Jennifer Nicole , Lewis Grant Kristine Sheena
Published: November 2022

This qualitative, instrumental case study explored existing instructional design practices as related to the accessibility of synchronous, virtual instructional content for adult learners with disabilities within a federal government agency. The purpose of study was to explore the experiences and perceptions of a group of learning professionals within a federal government agency community of practice and to examine the instructional design processes that currently exist within this group. Nine learning professionals participated in individual, semi-structured interviews and provide information regarding their experiences designing and delivering instruction and the accessibility features that are associated with such instruction. Six of the nine learning professionals submitted instructional artifacts from past synchronous, virtual learning events for content analysis; these artifacts were audited to determine the degree of accessibility. Five of the nine learning professionals who participated in the study were self-identified employees with disabilities who provided critical data about their experiences as both participants in and creators of instructional content. This study further explored these learning professionals' backgrounds, current practices, and the barriers that make it difficult to make synchronous, virtual learning events accessible for employees with disabilities. The qualitative data gathered from individual interviews and instructional artifacts was analyzed through various coding methods and themed to assist in understanding accessibility in synchronous, virtual instruction within the federal government agency that was the focus of this study. The results of this data analysis provided information that federal agencies and other government, corporate, and nonprofit organizations can apply to their own instructional design organizations can use to make accessibility a part of the instructional design process rather than merely add accessible features to instructional content after its creation in response to requests for accommodation.