bluuebunny/crossref_metadata_2025 huggingface dataset:
Professor Yuri Mikhailovich Butin – Military Translator, Orientalist, Economist and Historian
Authors:   Baikal State University, Kuzmin Y. V.
Published: December 2020

The author presents the creative biography of Professor Yu. m. Butin, a well-known orientalist, specialist in the ancient history of Korea and the Korean language. Yu. m. Butin created three departments of Oriental studies and world economy in Irkutsk universities, organized the teaching of the Korean language, published a textbook and manuals. Historian-orientalist Yu. m. Butin (1931–2002) – a major specialist in the ancient history of Korea, author of monographs: “Ancient Joseon” (Novosibirsk, 1982), “Korea: from Joseon to Three States” (Novosibirsk, 1984), which were included in the Golden Fund of Russian Korean studies. Later, these books were translated and published in South Korea in 1986 and 1990 in Seoul, and became firmly established in Russian and world Korean studies. The creative biography of Professor Yu. M. Butin, an orientalist, Korean scholar, historian and economist, deserves special research.
Le texte, comme un phénix… Approche des écritures de plateau
Authors: French French
Published: December 2020

Dans de nombreuses mises en scènes de la fin du XXe siècle et du début du XXIe siècle, le texte dramatique a pu sembler disqualifié, remis en cause dans sa légitimité à être l’origine même de toute dramaturgie. Le phénomène n’est pas nouveau puisque depuis les premières atteintes d’Antonin Artaud, le théâtre d’image a constamment désavoué la suprématie du théâtre de la parole. Si bien qu’il est légitime de s’interroger aujourd’hui sur les fonctions du texte théâtral et sur son rapport à la scène. Les nouvelles écritures dites « de plateau » ont notamment permis au discours théâtral de se renouveler. Devenu simple matériau des dramaturgies modernes, il a gagné un nouveau statut de « média-texte », mais il a aussi retrouvé une légitimité à « inspirer » l’espace imaginaire de la scène. N’étant certes plus la seule source originelle de la création théâtrale, en tant qu’œuvre « à monter », le texte a accepté sa fonction élémentaire de « substance » de la théâtralité (texte projeté, texte graphique, texte déconstruit, fragmentaire, voire impur) ; et, de fait, à la suite de cette métamorphose, c’est toute la littérature qui réinvestit le champ du théâtre, mais aussi le discours en général, puisque ce texte n’a plus obligation d’être « pièce » écrite pour le théâtre, mais celle de participer à la force dynamique d’un imaginaire qui se déploie en spectacle, mis en jeu sur un plateau par une communauté d’acteurs, corps et esprit en travail. Il s’agit d’interroger, à travers l’histoire et l’actualité, cette composante indéniable de la scène qu’est le texte de théâtre dans la mesure où si on a pu le croire à tort moribond, dépassé, déclassé ou hors-jeu, il semble au contraire renaître de ses cendres, plus éclatant que jamais, armé d’une nouvelle légitimité quasi politique, signe d’une urgence contemporaine à questionner la complexité du monde par une mise en jeu non moins complexe de sa représentation.

Mots clés : plateau – oralité– media-texte – performance – communauté
A la recherche du temps perdu de Marcel Proust : soixante minutes chrono
Authors: French French
Published: December 2020

Dans sa performance Tentative de résumer la Recherche du Temps perdu en une heure, l’artiste Véronique Aubouy propose un concept qui tient à la fois du conte, de la littérature et du théâtre. Elle réalise aussi un défi contre la montre qui ressemble à un challenge sportif. Réalisatrice, elle a passé l’essentiel de sa vie d’artiste derrière une caméra, rendant hommage à Proust dans un film-fleuve intitulé Proust lu. Le passage du film à la scène trouve sa cohérence dans la volonté de rendre hommage à un artiste dont l’œuvre a pris une place centrale dans sa vie. En pleine lumière, elle continue à se mettre en retrait par rapport au livre qu’elle veut mettre en valeur. Ce faisant, elle crée une forme artistique très originale, inédite sur la scène contemporaine.

Mots-clés : performance, oralité, conte, littérature, théâtre, réception, Proust
Le théâtre contemporain a-t-il un chœur ? La rédemption mouawadienne d’un dispositif refoulé
Authors: Armentano Nicoletta
Published: December 2020

S’interroger sur le chœur équivaut à questionner (tâche titanesque !) les fondements du théâtre occidental, voire même son origine. Le faire à partir d’une perspective qui est celle du théâtre contemporain, si d’un côté facilite la charge, de l’autre exige que l’on passe par une resémantisation du terme « chœur ». Au demeurant, comme le témoigne son essor depuis les années 1990, on lui préfère celui de « choralité ». Cela dit, un retour de ce dispositif sur la scène contemporaine reste indéniable : un retour qui questionne ses fonctions originelles, son statut et qui va bien au-delà de l’expression d’une polyphonie homogène ou du partage des croyances d’une communauté ressemblée. Or, réfléchir sur le retour du chœur à l’ère contemporaine implique aussi qu’on le fasse en corrélation avec une autre récupération voire réémergence : celle du tragique, de la tragédie grecque. Une récupération que loin de témoigner d’un goût pour l’archéologie ou pour une représentation abstraite d’un substrat mythique ou universel atteste, plutôt, un besoin de déterrer le souvenir d’une humanité enfouie (Cf. P. Pavis, 2007). En raison de cela, le cas de figure choisi pour mener cette enquête sur le chœur d’origine grecque sera la trilogie Des Femmes mise en scène par Wajdi Mouawad, en 2011. Ce spectacle, aboutissement d’une collaboration entre Mouawad (metteur en scène et acteur), Robert Davreu (traducteur des trois pièces de Sophocle – Les Trachiniennes, Antigone et Electre – dont se compose la trilogie) et Bertrand Cantat (chanteur et « metteur en musique » des chœurs du spectacle) porte en scène le souffle épique (et à ne pas négliger, autobiographique) auquel le dramaturge a désormais habitué son public, mais avec un militantisme et un engagement nouveau et/ou renouvelé envers les formes de l’écriture classique, dont l’attention portée au chœur est emblématique.

Mots clés : chœur – tragédie - théâtre contemporain – concert/performance - rédemption
Le roman postcolonial francophone et la refondation des imaginaires : les voix / voies féminines
Authors: French French
Published: December 2020

À l’instar de Kasereka Kavwahirehi, d’Achille Mbembe et d’Alain Mabanckou, les auteurs postcoloniaux soulignent depuis quelques années la nécessité de déconstruire et de dépasser les crises des sociétés africaines postcoloniales. Au niveau de la critique littéraire francophone, cela se traduit par des travaux qui s’intéressent aux moyens symboliques et /ou aux poétiques de la refonte des imaginaires. Toutefois, le rôle des femmes n’est pas encore suffisamment souligné, même si les personnages féminins sont parfois mis en exergue par les critiques. Dans cet article, je voudrais montrer que les voix féminines fortement au renouveau souhaité des sociétés africaines postcoloniales et que, par leurs paroles contestataires, elles donnent un souffle nouveau au projet réformateur desdites sociétés.

Mots-clés : Voix /voies féminines - refondation des imaginaires – crises postcoloniales – auteurs postcoloniaux
Les Antilles françaises et la départementalisation : de la domination « silencieuse » post-coloniale à l’aseptisation identitaire chez Édouard Glissant et Patrick Chamoiseau
Authors: French French
Published: December 2020

Quand les Africains demandaient leurs indépendances, les Antillais privilégiaient la départementalisation présentée comme une promesse de lendemains meilleurs. En effet, si l’éveil des consciences après la deuxième guerre mondiale a conduit les intellectuels africains à revendiquer leur liberté vis-à-vis de la France, il a poussé les Antillais à faire le choix de l’assimilation politique qui s’est traduite par l’adoption puis par la promulgation d’une loi qui fait de leurs îles des Départements d’Outre-Mer (DOM) et/ou des Territoires d’Outre-Mer (TOM) dès 1946. Ainsi, les Antilles sont restées françaises, car c’était la seule issue favorable qui pourrait contribuer à la naissance d’une vraie démocratie et au relèvement du niveau de vie de leurs peuples. Sur le plan culturel également, la politique assimilationniste apparaissait comme l’unique voie capable de réunir, sous le contrôle de la France, les différentes composantes de ces sociétés dépossédées de leurs valeurs ancestrales. Pour les défenseurs de cette politique assimilationniste, devenir français pallierait la crise identitaire et rendrait la parole à ceux qui ne l’ont jamais eue. Mais selon Patrick Chamoiseau et Édouard Glissant, cette politique assimilationniste demeure une forme de colonisation « silencieuse » conduisant à l’anéantissement de l’être antillais par un procédé d’aliénation culturelle insidieuse qui détruit leur(s) identité(s). Cependant, qu’est-ce qui explique la position de ces deux écrivains par rapport à la départementalisation ? Quels sont les arguments soulevés contre cette politique d’assimilation et de domination ? Nous présenterons dans un premier temps la politique de la départementalisation telle que vécue par les Antillais dans leur majorité et dans un second temps la construction d’un contre-discours par Glissant et Chamoiseau en analysant quelques-uns de leurs essais.

Mots-clés : Antilles, départementalisation, assimilation, identité, Antillanité, Créolité
Segura, Mauricio. Viral
Authors: Defraeye Julien
Published: December 2020

Segura, Mauricio. Viral

Compte rendu
Doom, Alain. Le club des éphémères
Authors: French French
Published: December 2020

Doom, Alain. Le club des éphémères

Compte rendu
Improved point center algorithm for K-Means clustering to increase software defect prediction
Authors: Annisa Riski , Rosiyadi Didi , Riana Dwiza
Published: December 2020

The k-means is a clustering algorithm that is often and easy to use. This algorithm is susceptible to randomly chosen centroid points so that it cannot produce optimal results. This research aimed to improve the k-means algorithm’s performance by applying a proposed algorithm called point center. The proposed algorithm overcame the random centroid value in k-means and then applied it to predict software defects modules’ errors. The point center algorithm was proposed to determine the initial centroid value for the k-means algorithm optimization. Then, the selection of X and Y variables determined the cluster center members. The ten datasets were used to perform the testing, of which nine datasets were used for predicting software defects. The proposed center point algorithm showed the lowest errors. It also improved the k-means algorithm’s performance by an average of 12.82% cluster errors in the software compared to the centroid value obtained randomly on the simple k-means algorithm. The findings are beneficial and contribute to developing a clustering model to handle data, such as to predict software defect modules more accurately.
Effect of grafting and harvest stage on the quality of black cherry tomatoes (Solanum lycopersicum cv. OG) cultivated in Vietnam
Authors: Ha H.T.N. , Thuy N.M.
Published: December 2020

Black cherry tomato is an important source of nutraceutical compounds; however, the
quality of fruits depends on the cultivation technique and maturity stage at harvest. In this
study, the physical and chemical properties of non-grafted and grafted tomatoes (Solanum
lycopersicum cv. OG) were evaluated at different stages of maturity to observe the effect
of grafting on quality of fruits and select the appropriate harvest stage to achieve the
highest content of bioactive compounds, especially anthocyanin. The obtained results
found that harvesting non-grafted tomatoes on the 30th day after fruit formation would be
suitable for storage with the highest anthocyanin level of 4.27 mg CE/100 g and the
content of other bioactive compounds (lycopene 24.60 μg/g, vitamin C 42.79 mg/100 g
and total phenolic 40.61 mg GAE/100 g). Meanwhile, the optimal harvest stage of grafted
tomatoes was shortened, on the 28th day (anthocyanin 4.31 mg CE/100 g, lycopene 38.79
μg/g, vitamin C 55.69 mg/100 g, and total phenolic 38.69 mg GAE/100 g). The grafting
technique should be applied for supporting the plant to grow faster as shown by the earlier
stage of harvest and the harvested fruit possessed higher content of bioactive compounds.
Investigation of the anti-cancer and apoptotic properties of aqueous extract from fermented African locust bean seeds
Authors: Ayo-Lawal R.A. , Sibuyi N.R. , Ekpo O. , Meyer M. , Osoniyi O.
Published: December 2020

Some fermented foods are reported to possess anti-cancer properties. Fermented African
locust bean seeds is a condiment prepared from fermentation of Parkia biglobosa. It has
been reportedly functional for various medicinal activities but not anti-cancer. The
cytotoxic and apoptosis-inducing properties of the aqueous extract of the condiment were
investigated in human cancer - hepatocellular (Hep-G2) and cervical (HeLa) and noncancer cell lines. Cytotoxicity was evaluated using the 3-(4,5-dimethylthiazol-2-yl)-2,5-
diphenyl tetrazolium bromide (MTT) and clonogenic cell survival assays. Apoptotic cell
death and DNA fragmentation were also investigated. The results revealed cytotoxicity to
both cell lines in a dose-dependent manner (P < 0.05) and selective activities between
cancer and non-cancer cells. The IC50 values were 1.3 and 0.5 mg/mL for Hep-G2 and
HeLa cells respectively. Furthermore, the extract induced apoptotic cell death in only Hep
-G2 (73.03±0.73) cells. The morphologic photomicrographs correlated well with other
findings, indicating the cell-specific cytotoxicity of the condiment
Effect of Moringa leave Marinade on aflatoxin in fresh and smoked African catfish (Clarias gariepinus)
Authors: Oni E.O. , Adetunji M.C. , John-Babatunde D.D. , Omemu A.M.
Published: December 2020

This study aimed at evaluating the effect of Moringa leaves Marinade (MOM) on
aflatoxin contamination of Clarias gariepinus. A total of thirty fresh fish samples (n = 30)
grouped into four; Fresh fish without smoking and storage, smoked fish +1% and 2%
Moringa oleifera Marinade (MOM) respectively and Control (0% MOM) were subjected
to microbiological and HPLC analysis while storing for 0-3 months. Mean CFU/g of 2.8
and 3.1 x 102 CFU/g for bacteria and fungi were recovered, respectively. Furthermore,
four bacteria and fungi genera each of which Aspergillus spp. was the most predominant
(57%) were recovered from the fishes. Aflatoxin concentration increased progressively in
0% MOM smoked fish as the storage period increased, while aflatoxin concentration
reduced in the fishes treated with 2% MOM (p≥0.05). On average, between 1-40%
reduction in aflatoxin concentration and increased keeping quality was enhanced with 2%
MOM treatment. These findings recommend the possibility of the use of moringa leaves
in the treatment of commercially smoked fish.
Improvement the firmness of thermal treated black cherry tomatoes (Solanum lycopersicum cv. OG) by low-temperature blanching in calcium chloride solution
Authors: Ha H.T.N. , Thuy N.M.
Published: December 2020

The objective of this study was to investigate the effects of low-temperature blanching in
calcium chloride (CaCl2) solution before high-temperature processing (90oC for 1 min) on
physicochemical properties related to the texture (total calcium content, pectin
methylesterase (PME) activity, and firmness) of black cherry tomatoes (Solanum
lycopersicum cv. OG) and to determine the optimum conditions to provide the fruits with
the highest firmness. Response Surface Methodology (RSM) was applied to design the
experiment with three factors of blanching temperature (52 to 68oC), blanching time (12 to
28 mins) and CaCl2 solution concentration (1.2 to 2.8% w/v). A sample without lowtemperature treatment was taken as a control. It was found that the blanching of tomatoes
at low-temperatures resulted in higher total calcium content and PME activity in tissue
after the treatment, and therefore improved the firmness of fruits after high-temperature
processing. The highest firmness of treated tomatoes (566.21 g force) was estimated at
blanching temperature of 62.05oC for 23.09 mins in 2.08% CaCl2 solution compared to the
control which was blanched at high temperature (218 g force). Under these optimized
conditions, the experimental responses (total calcium content, PME activity, and firmness)
showed a close agreement with the predicted values.
Current Issues of Medical Support of Innovative Scientific and Pedagogical Projects
Authors:   V. N. Karazin Kharkiv National University. 4, Svobody Sq., Kharkiv 61022, Ukraine, Sotnikova-Meleshkina Zh. V.
Published: December 2020

The modern education system is characterized by the introduction of new, specialized, and author's programs, which are highly variable, accompanied by the intensification of the educational process, increasing the total workload, reducing physical activity, and deteriorating the structure of the daily routine of students. Such changes in the organization of the educational process lead to an increase in the level of pathological lesions, asthenoneurotic reactions, and symptoms of dysfunction of somatic systems. A particularly vulnerable category of students is gifted children, who on the one hand, experience discrimination at school due to the partial lack of differentiated learning, focus on the average student, and excessive unification of programs that do not take into account individual learning opportunities. On the other hand, intellectually gifted children showed a decrease in overall reactivity and tension of adaptation mechanisms, greater susceptibility to acute infectious diseases, the presence of autonomic disorders, hypotension and syncope, more often registered pathology of the gastrointestinal tract, musculoskeletal system, and allergies conditions than at the "average intellectuals". Therefore, this category of students needs a special approach and a deeper study of the impact of elements of the learning process on their health. Two separate areas of research have been formed by now. They are related to the study of psychological and pedagogical aspects of teaching children on innovative educational technologies, on the one hand, and the state of health of schoolchildren, on the other hand. However, only a few studies have been conducted where these two areas are combined and the direct impact of the educational process on new educational projects on disorders in morphofunctional, psychoemotional, and general health of students is determined, risk factors of the educational process are identified and recommendations for the prevention of school maladaptation are provided. Conclusion. Information analysis of scientific sources on current issues of education and medical care for gifted children and adolescents shows the interest of society in conducting further medical and pedagogical research to develop preventive measures to preserve their health. There is an urgent need for hygienic optimization of educational activities, proper regulation of innovative pedagogical technologies, development of appropriate guidelines for the prevention of school maladaptation
Retrospective Analysis and Current State of Experimental Models of Blast-induced Trauma
Authors:   State Institution Dnipropetrovsk Medical Academy of the Ministry of Health of Ukraine. 9, Vernadsky St., Dnipro 49044, Ukraine, Kozlova Yu. V. , Kosharnij A. V. , Korzachenko M. A. , Kytova I. V.
Published: December 2020

Combat pathology, particularly mine-blast injury is the main cause of military casualties. In our country, as a factor of destabilization, are widely used terrorist attacks using explosive devices of different capacities. Blast injury over 60% is cause of military casualties during armed conflicts. It is known that the condition for the formation of air-shock wave is creating waves of pressure, which is distributed at supersonic speed as possible with pulsed gas explosion and expansion of compression ambient air. The brain, chest, abdomen, and bladder are the most sensitive parts of the human body to blast. But the pathogenesis, diagnosis, treatment and rehabilitation of post-traumatic explosion-induced disorders, namely, neurodegenerative complications psychosomatic, cognitive impairment, currently not fully understood and are not clear enough for an adequate therapy. The purpose of the study was to analyze the advantages and disadvantages of experimental models of blast-induced injury and to improve method and compressed air-driven shock tube. Material and methods. We used the following methods: analysis and evaluation of experimental models of explosion-induced injury by scientific publications, monographs and invention obtained in stages patent information search in the library collection of the State institution "Dnipropetrovsk Medical Academy of the Ministry of Health of Ukraine" (October 2019), a retrospective search of the literature database PubMed (February 2020). Results and discussion. A retrospective analysis of the number of literary sources on the experimental reproduction of explosive trauma has shown a high interest of a large circle of scientists in the last decade. A qualitative study of scientific publications has shown a wide range of physical characteristics of an experimental shock wave, methods and devices for simulating an explosive injury. The absence of a standardized model of explosive injury with characteristics as close as possible to real circumstances creates conditions for the implementation of our own proposals. Conclusion. This work presents a tested modified experimental model for reproducing an air shock wave under laboratory conditions, which makes it possible to study the features of the course of an explosive injury of various organs and organ systems at various periods after injury
Structural Features of Skin Reparative Regeneration of Mature Rats under the Chronic Hyperglycemia
Authors:   Sumy State Univercity. 2, Rymskogo-Korsakova St., Sumy 40007, Ukraine, Maksymova O. S. , Muravsky D. V. , Tkach G. F.
Published: December 2020

Diabetes is one of the most common condition in the world which is rightly interpreted as a non-infectious pandemic. The wounds are one of most common traumatic injuries, constitute a significant proportion of surgical pathology and are a serious medical problem throughout the world. The disruption of the carbohydrate exchange has a negative impact on the healing process, which can be long and difficult to treat. The problem of repaired damaged skin of various etiologies remains relevant today. The purpose of our research was to study the microstructural and planimetric features of the skin reparative regeneration of mature rats under the chronic hyperglycemia. Material and methods. The study was conducted on 60 white laboratory mature rats: a control group, a group of animals with chronic hyperglycemia of the body. The chronic hyperglycemia was simulated by the single intraperitoneal administration of streptozotocin (40 mg/kg) and nicotinic acid (1 mg/kg). The wound was formed by cutting out a piece of skin in the interscapular region. The studies were performed on the 7, 14 and 21 days after trauma. The light microscopy was performed using an Olympus BH-2 microscope (Japan), the planimetric analysis was performed using the morphometric program "Digimizer". The statistical analysis was performed using the SPSS-17 software package. Results and discussion. The study results showed that the process of the skin regeneration of mature rats with the chronic hyperglycemia is of the unfinished character and reveals as a violation of the epithelialization process, angiogenesis, keratinization and reorganization of connective tissue into a full-fledged dermis. The main features of the process of post-traumatic skin regeneration of rats with chronic hyperglycemia are the prolongation of the reduction of wound area at the all study stages. The wound healing rate in the rats with the chronic hyperglycemia was the largest on the 21st day of the experiment and was (7.69±1.97) mm2 / day, while in control rats the wound healing rate at the end of the experiment was the lowest and amounted to (2.87±0.32) mm2 / day. The wound healing rate were clearly correlated with the dynamics of wound healing in both groups. Conclusion. In our study, we also observed a prolongation of the inflammatory phase and delayed recovery processes in animals with chronic hyperglycemia. In these animals there was a decrease in the rate of wound healing with a weak tendency to increase it at the end of the experiment. In the control group, on the contrary, the rate of wound healing was higher in the initial stages of the study, and decreased in the end. Speed rates were clearly correlated with the dynamics of wound defect healing in both groups
Clinical and Morphological Analysis of Adrenal Glands Pathology in Kharkiv Region (according to Archival Material for the Period 2015-2019)
Authors: Sorokina I. V. , Markovskyi V. D. , Goidenko N. I. , Kaluzhyna O. V.
Published: December 2020

The adrenal glands play an important role in the functioning of the human body. There are more opportunities for early tumors detection of these endocrine glands thanks to modern diagnostic procedures, but the problem is very relevant. Morphological investigation is the basis for differentiating adrenocortical adenoma from carcinoma. Material and methods. The article presents the clinical and morphological features of the adrenal glands pathology in Kharkiv region in the period 2015-2019 by analyzing the archival histological material of 77 patients who were operated in hospitals of the State Institution "Institute of General and Emergency Surgery named after V. T. Zaitsev of National Academy of Medical Sciences of Ukraine" and "V. Danilevsky Institute for Endocrine Pathology Problems of the National Academy of Medical Sciences of Ukraine". Results and discussion. The study established that in 2015 there were 18 cases (including 8 malignant tumors), in 2016 – 16 cases (2 cases with bilateral damage, 1 malignant tumor), in 2017 – 12 cases, in 2018 – 20 cases, in 2019 – 11 cases. All tumors were benign in the last 3 years of the study. We calculated that 48.6 years was the average age of patients with this localization tumor processes (20-75 years). Women suffered more often than men (61.03% and 38.97%, respectively). Both adrenal glands had pathological changes in 2 people. The left gland is most often affected. The vast majority of the formations in 2015-2019 were benign (88.61%). Adrenocortical adenomas (45 cases, mostly clear cell variant, leftward, in women) and mature pheochromocytomas (13 cases, uncomplexed variant, leftward, in men), adrenal cysts (6 cases, more often on the right, in men, with a dense fibrous capsule), hyperplasia of the cortical, cerebral or both layers (4 cases), ganglioneuroma of the adrenal medulla (1 case) and a combination of pheochromocytoma with two adrenocorticosteromas (1 case) were among them. Conclusion. Malignant tumors were represented by malignant corticosteromas (5 cases out of 9, leftward, various sizes, with secondary changes in tumor tissue), malignant pheochromocytomas (3 cases out of 9, right, different size) and malignant paraganglioma (1 case). The larger size of the tumor did not always correlate with the nature of the process
Diagnostic Value of Clinical and Laboratory Parameters in the Diagnosis of Non-Specific Ulcer Colitis
Authors:   OO Bohomolets National Medical University. 13, T. Shevchenko Boulevard, Kyiv 01601, Ukraine, Lutsyk A. P. , Shorikov E. I. ,   Higher State Educational Establishment of Ukraine Bukovinian State Medical University. 2, Theatralna Sq., Chernivtsi 58002, Ukraine
Published: December 2020

The etiology of ulcerative colitis is still unknown. The number of works dealing with a comprehensive assessment of the role of clinical, laboratory, endoscopic, as well as immunological and genetic factors in the formation of unfavorable forms of ulcerative colitis is extremely small, and their results seem ambiguous. The purpose of the study was to determine the diagnostic value of clinical and laboratory signs in relation to verification of the depth of endoscopic lesion in patients with ulcerative colitis. Material and methods. 68 patients with ulcerative colitis (36 men and 32 women) were examined. The average age was 38.0±4.5 years. All patients were inspected with colonoscopy. Clinical, laboratory, immunological research, as well as computed tomography were carried out. Disease activity was determined according to the Truelove-Witts classification. Results and discussion. The obtained results showed that all intestinal symptoms (stool frequency more than 4 times a day, abdominal pain, tenesmus, hematochezia) had a reliable diagnostic value (р<0.05) in the presence of contact vulnerability and ulceration of the intestinal mucosa. The greatest sensitivity was characteristic of abdominal pain (94.1 [84.1-96.3]). It was found that the diagnostic sensitivity of tachycardia and uveitis is unreliable. Among the clinical indicators, the greatest diagnostic value was established for anemic syndrome (p<0.05), among additional signs was for sclerosing cholangitis (p<0.05). With regard to laboratory parameters, the diagnostic value was proven for hemoglobin levels <90 g/l (p<0.05) and hypoproteinemia (p<0.05). The diagnostic concentration of C-reactive protein for predicting a mucosal defect was determined at a level of more than 10 mg/L in terms of sensitivity and specificity (p<0.05). The level of fecal calprotectin more than 200 μg/g (p<0.05) was highly sensitive and highly specific. Conclusion. The study showed the possibilities of computed tomography for verifying of ulcerative defects. The method is highly sensitive in ulcerative colitis (sensitivity is 95.6 [85.9-97.1], specificity is (96.7 [83.3-99.4]), with a low probability of false-negative and false-positive results (p<0.05)
Rare Radiation Complications after Treatment of Cervical Cancer
Authors:   State Organization Grigoriev Institute for Medical Radiology NAMS of Ukraine. 82, Pushkinskaya St., Kharkiv 61024, Ukraine, Sukhina О. М. , Nemaltsova K. V. ,   State Organization Grigoriev Institute for Medical Radiology NAMS of Ukraine. 82, Pushkinskaya St., Kharkiv 61024, Ukraine,   V. N. Karazin Kharkiv National University. 4, Svobody Sq., Kharkiv 61022, Ukraine, Sukhin V. S. ,   State Organization Grigoriev Institute for Medical Radiology NAMS of Ukraine. 82, Pushkinskaya St., Kharkiv 61024, Ukraine,   V. N. Karazin Kharkiv National University. 4, Svobody Sq., Kharkiv 61022, Ukraine
Published: December 2020

Currently, cervical cancer is one of the most common types of oncological pathology. Radiation therapy is the main treatment for patients with locally advanced cervical cancer. The main goal of radiation treatment for cervical cancer is to plan the amount of radiation in which the primary tumor and the areas of regional lymph outflow are subject to the maximum possible impact with minimal radiation exposure to critical organs (rectum and bladder). However, the program of combined radiation therapy according to a radical program in patients with locally advanced cervical cancer provides for irradiation of sufficiently large volumes with high therapeutic doses. Radiation therapy with radiomodifying cytostatics or with competitive polychemotherapy improves both immediate and long-term results of treatment, but increases the risk of radiation reactions. According to clinical signs, radiation toxicity is divided into general and local, which, in turn, can be early and late, depending on the time of occurrence. The risk of radiation damage naturally increases with an increase in the total absorbed dose. The presence of comorbidities also affects the likelihood of post-radiation complications. Chronic diseases of organs located in the irradiated zone significantly increase the risk of their radiation damage. Individual radiosensitivity plays a decisive role in the occurrence of radiation complications. The article describes a case of a urinary-small intestinal fistula in patient A., 80 years old. The patient has been observed in the clinic of the State Organization «Grigoriev Institute for Medical Radiology and Oncology National Academy of Medical Sciences of Ukraine» since 2016 for cervical cancer FIGO IVA stage (pathohistological conclusion was squamous cell non-keratinizing cancer), a course of combined radiation therapy with modification of 5-fluorouracil under a radical program was carried out. The relapse-free period for cervical cancer was 4 years, the patient regularly underwent control examinations at the Institute's clinic. Since March 2020 has had complaints about the presence of feces in the urine, which is why she came to the clinic. Conclusion. Treatment of this category of patients is a difficult task that requires time and great effort from both medical staff and patients
Microbial Composition of Dental Clinics’ Air as a Factor of Spread of Nosocomial Infections
Authors:   Uzhhorod National University. 3, Narodna Square, Uzhhorod, Transcarpathian region 88000, Ukraine, Horzov L. F. , Kryvtsova M. V. , Kostenko Y. Y. , Kalynyak M. M.
Published: December 2020

The air environment of medical institutions plays a significant role in the spread of pathogens of a number of nosocomial infections, primarily coagulase-positive staphylococci, as well as respiratory viruses and pathogens of some mycoses. Nowadays, in the epidemiological situation regarding Covid-19, more and more attention is paid to the issues of microbiological assessment of air quality in medical institutions. The constant circulation of pathogenic and opportunistic microflora and the associated potential risk of infection of medical personnel is due to the specifics of the work process in dentistry. The purpose of this study was to conduct a sanitary-microbiological study of the air. Material and methods. Sampling was carried out by sedimentation method in 14 offices of dental clinics. Petri dishes with nutrient media, meat peptone agar and bile salt agar were placed on a horizontal surface at the level of human respiratory organs. The number of microorganisms grown on the nutrient medium was counted after 24 hours of incubation. Results and discussion. The obtained results showed that in the studied premises, the total microbial count varied from 756±0.8 Colony-forming units /1m3 to 6497±3.4 CFU / 1m3. Thus, only in 4 rooms the air was clean according to microbiological criteria, in 3 - questionable and in - 6 polluted. Analysis of the presence of sanitary-indicative microorganisms showed that S. aureus was not detected in 2 rooms in the air, in others - the amount of staphylococcus varied from 2 to 8 CFU / 1m3. Microscopic fungi were not detected in only 4 rooms. In other rooms, the number of microscopic fungi varied from 12 to 345 CFU/m3. Microbial air pollution is the greatest danger in medical institutions, especially infectious, surgical, burn and maternity wards, as it plays a leading role in the spread of nosocomial infections. At the same time, dental institutions pose a special danger in terms of the high prevalence of microorganisms in the air. Formation of aerosols consisting of small drops of oil, saliva, water, dust, manure, blood, microorganisms when working with high-speed turbines, drills, ultrasonic devices. Aerosols can be kept in the breathing zone of the doctor and the patient for up to 30 minutes and spread over a distance of up to 50-80 cm. When using water cooling, the diameter of the aerosol cloud reaches two meters. Conclusion. The systematic assessment of the air environment in dental offices and the development of a system of effective monitoring and measures to prevent aerogenic transmission of infectious diseases is of particular importance. The development of recommendations for the organization of nosocomial infections prevention in dental institutions is a promising task to be solved
Features of the Influence of Tobacco Heating Systems (GLO and IQOS) on the Oral Tissues Condition
Authors:   Lviv Danylo Halytskyi National Medical University. 69, Pekarskaya St., Lviv 79010, Ukraine, Ilchyshyn M. P. , Furdychko A. I. , A. Ya. Barylyak , Fedun I. R. , Gan I. V.
Published: December 2020

In Ukraine, there is a noticeable tendency to increase the incidence of oral tissue diseases due to the presence of concomitant pathology, the negative impact of environmental factors, namely the presence of bad habits. In recent years, due to numerous clinical studies that have confirmed the effects of smoking on the human body as a whole, leading tobacco companies are making great efforts to develop less harmful nicotine-containing products for public health. These include electronic cigarettes and tobacco heating systems. Research on their effects on human health is still ongoing. And none has an evidentiary answer, including from international organizations. The purpose of this study was to investigate the intensity and prevalence of dental hard tissue diseases and periodontal tissue pathology among people who use tobacco heating systems (GLO and IQOS). Material and methods. The article describes the study results of dental hard tissues and periodontal tissues in 75 patients, including 39 people with nicotine dependence, who were tested for caries intensity, resistance of tooth hard tissues to caries, hygiene index, iodine number of Svrakov and the prevalence of periodontal disease. Results and discussion. We determined that individuals who used tobacco heating systems had the worst values of the studied indicators. The prevalence of periodontal diseases was significantly higher than in the surveyed comparison groups, and the increase in the duration of their use was accompanied by an increase in the incidence of periodontal diseases and their severity. Conclusion. The results of the study proved that the use of tobacco heating systems by patients was a negative factor that increased the intensity of caries, reduced the resistance of hard tissues to caries, deteriorated oral hygiene and provoked the development of inflammatory and dystrophic inflammatory diseases of periodontal tissues. The obtained results confirmed the presence of harmful effects on tissues and organs of the oral cavity, provided the use of drains for tobacco heating systems (GLO and IQOS). In our opinion further clinical studies will be promising to provide professional care to thematic patients
Comparison of the Therapeutic Alliance Indicators according to the Results of the Survey of Cardiosurgical Patients and their Physical Therapists
Authors:   National university of physical training and sport of Ukraine. 1, Fizkultury St., Kyiv 02000, Ukraine, Vitomskyi V. V. , Al-Hawamdeh K. M. , Vitomska M. V. , Gavreliuk S. V.
Published: December 2020

The purpose of the study was to determine and compare the indicators of the therapeutic alliance based on the results of a survey of cardiac surgery patients and their physical therapists. Material and methods. The survey involved 100 patients (over 18 years old, without cognitive impairment) who underwent cardiac surgery. The Working Alliance Inventory questionnaire was used to assess the level of therapeutic alliance formation. The SF Hatcher Client form (which consists of 12 questions) was used for the patient. These questions were divided into three groups / domains: "goal items", "task items" and "bond items". The questionnaire was filled in on the seventh postoperative day. The SF Hatcher Client form, which consisted of 12 questions, was used for the patient. Intervention: before surgery, patients received a short consultation with a physical therapist regarding the goals and content of physical therapy, the algorithm for activation after surgery; the postoperative physical therapy protocol included early mobilization, therapeutic gymnastics, the use of respiratory physical therapy techniques, and therapeutic walking under the supervision of a physical therapist. Patients were provided with information and tasks on therapeutic walking, a small set of therapeutic exercises and breathing physical therapy for independent implementation. Results and discussion. The indicators of the therapeutic alliance between physical therapists and cardiac surgery patients confirmed its high level, both according to the results of the questionnaire survey of patients and the results of the survey of specialists. The "goal items" domain had the highest score in the patient's assessment of therapeutic alliance. Since the patient and specialist questionnaires had a different number of questions and a different maximum score, it was decided to make comparisons of the overall estimates of the level of therapeutic alliance after converting them to a percentage of the maximum. A significantly better overall score for the therapeutic alliance was established according to the results of the questionnaire survey of physical therapists: 87.5 (82.5; 95) % of the maximum versus 81.25 (66.67; 89.58) % of the maximum (p = 0.000). Conclusion. Physical therapists rated the therapeutic alliance for a higher score
Neonatal Screening for Monogenic Inborn Pathology in Ukraine
Authors: Omelchenko E. M. , Polka O. O. , Karamzina L. A.
Published: December 2020

The International Clearinghouse for Surveillance and Research on Congenital Defects is collecting data from surveillance of birth defects and research programs around the world to investigate, prevent and mitigate birth defects. In Ukraine, data collection on the prevalence of congenital malformations is carried out by the national profile regulator – the Ministry of Health. There is a spectrum of risk factors that increase the prevalence of genetic birth defects leading to neonatal and infant mortality, mental retardation and lifelong disability. Screening programs, including neonatal genetic screening, help to avoid such risks. Such testing with a stable detection result is carried out only for 3 diseases: phenylketonuria, hypothyroidism, cystic fibrosis today in Ukraine. The purpose of the study was to evaluate the results of screening for monogenic pathology among newborns in Ukraine. Material and methods. The results of screening for hereditary pathology of newborns in Ukraine were evaluated over a 10-year period: from 2010 to 2019. The information base was the data of official medical statistics. Out of 4,308,100 live births, 9,199,817 newborns were covered by neonatal genetic screening. The presence of genetic pathology was identified and confirmed at 1313 children. Results and discussion. According to a group of researchers from the Wadsworth Center (New York, USA), the development of the science of newborn screening, especially with new technologies, providing new types of information (genetic and physiological) for each new condition, is possible only with pilot programs. During 2010-2019 in Ukraine neonatal genetic screening covered phenylketonuria in 89.56% of newborns, hypothyroidism in 84.43% of newborns, and cystic fibrosis in 39.55% of newborns. It is necessary to create a state program of mass examination for hereditary diseases that can be treated. The main purpose of such a program is to predict the dynamics of genetic load among the population to develop the necessary medical and social measures. A decrease in the number of births of children with congenital malformations is possible in the context of government programs aimed at reducing risk factors causing congenital anomalies, as well as taking preventive measures. The main goal of such a program is to predict the dynamics of the genetic load among the population in order to develop the necessary medical and social measures. Conclusion. In Ukraine today there are no targeted programs for comprehensive prevention of congenital pathology. Improvement of the situation is possible through the involvement of high technologies, allowing to expand the panel of genetic screening to start early treatment and reduce negative results. Genetic screening has been shown to be an effective tool for detecting congenital metabolic disorders
Sanitary and Microbiological Research of Fish Products Sold in Dnipro city
Authors: Bilousova A. A. , Cherevach N. V. , Dregval O. A. , Golodok L. P. , Sklyar T. V.
Published: December 2020

Fish is a valuable food product that has a high biological value, but spoils quickly because its muscle tissue contains a lot of moisture and can be contaminated with microflora through the intestines, mucus of the skin and gills. Insufficiently fresh fish can cause serious diseases: toxicoinfections and toxicosis, intestinal infectious diseases caused by Shigella, Salmonella, Escherichia coli, Proteus, Clostridia, various coccal microflora. The urgency of this problem encourages the study of sanitary-indicative microorganisms of fish and seafood to prevent foodborne infections. The purpose of the work was to study the microbial contamination of ready-to-eat fish and seafood sold in the retail chains of the city of Dnipro, to determine the compliance of product quality with sanitary requirements. Material and methods. 53 samples of fish and seafood of different brands were analyzed: 23 samples of low-salt products, among which were preserves from fish "Herring", preserves from mussels, salted low-salt and 30 dried products: dried squid, dried squid rings and dried bull. The number of mesophilic aerobic and facultative anaerobic microorganisms, Escherichia coli bacteria, the presence of coccal microflora, mold and anaerobes were determined in each of the samples. Results and discussion. The results of the sanitary-microbiological study showed that 43.4% of the analyzed samples (23 samples) did not meet the normative indicators. The largest deviations from the norm were found in the content of mesophilic aerobic and facultative anaerobic microorganisms and Escherichia coli bacteria. The study showed that in 39.6% of samples the number of mesophilic aerobic and facultative anaerobic microorganisms was exceeded, and in 32.0% - the number of Escherichia coli bacteria. Most contaminated products were found among the samples of dried squid – 50% of samples, preserves from fish "Herring" – 36.4% and preserves from mussels – 36.4%, dried squid rings – 33.3%. It was found that 18.8% of samples of fish and fish products contained Staphylococcus aureus, 7.5% of samples – sulfate-reducing clostridia. Conclusion. The obtained results indicated the non-compliance of a large number of fish and seafood with the normative indicators. This may be due to the condition of the reservoirs in which the catch was made, improper processing of raw materials, non-compliance with storage conditions, transportation of the product. Therefore, it is important to further improve the quality of fish products by controlling raw materials, compliance of production technology with international and national standards. The solution of this problem is possible under the condition of state involvement in the process of quality control of fish products on the market of Ukraine. The results of research can be used to monitor the quality of fish and seafood sold in retail chains