bluuebunny/crossref_metadata_2025 huggingface dataset:
LIN28B regulates transcription and potentiates MYCN-induced neuroblastoma through binding to ZNF143 at target gene promotors
Authors: Tao Ting , Shi Hui , Mariani Luca , Abraham Brian J. , Durbin Adam D. , Zimmerman Mark W. , Powers John T. , Missios Pavlos , Ross Kenneth N. , Perez-Atayde Antonio R. , Bulyk Martha L. , Young Richard A. , Daley George Q. , Look A. Thomas
Published: June 2020

Significance

LIN28B is well known as a RNA-binding protein and a suppressor of microRNA biogenesis by selectively blocking the processing of
let-7
precursors. However, little is known about
let-7
–independent roles of LIN28B. Here, we show that LIN28B is recruited to active promoters by binding to the zinc-finger transcription factor ZNF143. LIN28B acts as a cofactor to upregulate expression of a subset of downstream target genes that are essential for neuroblastoma cell survival and migration. Our paper reveals an unexpected role of LIN28B in transcriptional regulation that is independent of
let-7
during neuroblastoma pathogenesis.
The capillary Kir channel as sensor and amplifier of neuronal signals: Modeling insights on K
+
-mediated neurovascular communication
Authors: Moshkforoush Arash , Ashenagar Baarbod , Harraz Osama F. , Dabertrand Fabrice , Longden Thomas A. , Nelson Mark T. , Tsoukias Nikolaos M.
Published: June 2020

Significance

Local brain activity is rapidly accompanied by a vascular response to increase blood perfusion. How neuronal activity is sensed by the vasculature is not fully understood. This process, known as neurovascular coupling, constitutes the physiological basis of functional neuroimaging scans and its disruption is associated with cognitive disorders and stroke. We have recently demonstrated the active involvement of capillary endothelial cells in neurovascular communication through the activity of Kir channels. Here, using a computational modeling approach, we investigate the biophysical determinants of capillary-mediated neurovascular coupling. Simulations show how capillary Kir channels sense neuronal activity and initiate and amplify electrical signals—through a process that resembles electrical activity in excitable cells—to produce a robust vasodilatory response.
Multiple transpolar auroral arcs reveal insight about coupling processes in the Earth’s magnetotail
Authors: Zhang Qing-He , Zhang Yong-Liang , Wang Chi , Lockwood Michael , Yang Hui-Gen , Tang Bin-Bin , Xing Zan-Yang , Oksavik Kjellmar , Lyons Larry R. , Ma Yu-Zhang , Zong Qiu-Gang , Moen Jøran Idar , Xia Li-Dong
Published: June 2020

Significance

Colorful and dynamic aurora has attracted human’s attention since the dawn of time. However, mystery remains in understanding a distinct class of aurora, transpolar auroral arc (TPA) (or “theta” aurora) which occurs in extremely high latitude of the Earth polar regions when interplanetary magnetic field (IMF) is northward. Previous theories are unable to explain why multiple TPAs often occur. Our comprehensive observations in the ionosphere and magnetotail as well as a three-dimensional magnetosphere modeling shed insight on how multiple TPAs form. Our study offers clues how solar wind energy and mass transfer into the magnetosphere and ionosphere under a northward IMF that occurs nearly half of the time.
An essential role for cardiolipin in the stability and function of the mitochondrial calcium uniporter
Authors: Ghosh Sagnika , Basu Ball Writoban , Madaris Travis R. , Srikantan Subramanya , Madesh Muniswamy , Mootha Vamsi K. , Gohil Vishal M.
Published: June 2020

Significance

The assembly and function of membrane proteins depend on the lipid milieu. In recent years the protein components of the mitochondrial calcium uniporter have been identified, but its specific phospholipid requirements are not known. Utilizing yeast mutants defective in their ability to synthesize different phospholipids, we identify a specific requirement of cardiolipin (CL) in the stability and function of the mitochondrial uniporter. Our findings are translatable to higher organisms because endogenous uniporter abundance is decreased in patient-derived cells and cardiac tissue from Barth syndrome, an inherited deficiency in CL levels. This work shows that yeast phospholipid mutants can be leveraged to uncover specific lipid requirements of membrane proteins and suggests impaired mitochondrial calcium signaling in the pathogenesis of Barth syndrome.
Fibroblast–tumor cell signaling limits HER2 kinase therapy response via activation of MTOR and antiapoptotic pathways
Authors: Zervantonakis Ioannis K. , Poskus Matthew D. , Scott Alexis L. , Selfors Laura M. , Lin Jia-Ren , Dillon Deborah A. , Pathania Shailja , Sorger Peter K. , Mills Gordon B. , Brugge Joan S.
Published: June 2020

Significance

Factors stemming from the tumor microenvironment can modulate drug resistance. Therefore, rational approaches to design efficacious targeted therapies are needed. Here, we show that fibroblasts reduce lapatinib sensitivity in a subset of HER2
+
breast cancer cells via paracrine signaling that can be reversed by targeting downstream survival programs such as MTOR and antiapoptotic proteins (BCL-XL and MCL-1). Our finding that fibroblasts derived from either primary tumor or metastatic sites limit lapatinib response has important implications for developing treatment strategies that can restore sensitivity in multiple drug-resistant microenvironments. Due to the diversity of microenvironmental factors between these sites, targeting downstream survival programs instead of individual factors released by fibroblasts represents a promising strategy to combat microenvironment complexity.
Using synthetic biology to overcome barriers to stable expression of nitrogenase in eukaryotic organelles
Authors: Xiang Nan , Guo Chenyue , Liu Jiwei , Xu Hao , Dixon Ray , Yang Jianguo , Wang Yi-Ping
Published: June 2020

Significance

Stable expression of each component of the nitrogenase system in an active form is a prerequisite for engineering nitrogen fixation in eukaryotic cells. Mitochondria provide an oxygen-depleted environment for the expression of active nitrogenase in plants, but signal peptides are required to target nuclear encoded Nif proteins to this organelle. We demonstrate that one of the structural subunits of nitrogenase, NifD, is itself susceptible to cleavage by mitochondrial processing peptidases from a variety of plant origins, presenting a major challenge to engineering nitrogen fixation in mitochondria. To overcome this issue, we have engineered NifD variants that are resistant to cleavage and retain high levels of nitrogenase activity, thus providing a potential solution for engineering active MoFe protein in plants.
Active forces shape the metaphase spindle through a mechanical instability
Authors: Oriola David , Jülicher Frank , Brugués Jan
Published: June 2020

Significance

The mitotic spindle machinery is a bipolar structure that segregates sister chromatids during cell division. Spindle assembly relies on the self-organization of motor proteins and microtubule filaments—dynamic polymers that constitute the spindle building blocks. How motors ensure a bipolar spindle-like structure is not understood. Here we build a liquid crystal droplet description of the spindle that quantitatively accounts for pole focusing as a function of dynein activity. Our results show how active forces driven by molecular motors can shape liquid crystalline droplets.
Dissecting the mechanism of signaling-triggered nuclear export of newly synthesized influenza virus ribonucleoprotein complexes
Authors: Schreiber André , Boff Laurita , Anhlan Darisuren , Krischuns Tim , Brunotte Linda , Schuberth Christian , Wedlich-Söldner Roland , Drexler Hannes , Ludwig Stephan
Published: June 2020

Significance

Influenza viruses (IV) replicate in the nucleus. Export of newly produced genomes, packaged in viral ribonucleoprotein (vRNP) complexes, relies on the nuclear CRM1 export pathway and appears to be timely controlled by virus-induced cellular signaling. However, the exact mechanism of the signaling-controlled complex assembly and export is enigmatic. Here we show that IV activates the Raf/MEK/ERK/RSK1 pathway, leading to phosphorylation at specific sites of the NP, which in turn, creates a docking site for binding of the M1 protein, an initial step in formation of vRNP export complexes. These findings are of broad relevance regarding the regulatory role of signaling pathways and posttranslational modifications in virus propagation and will strongly support ongoing development of an alternative anti-influenza therapy.
Highly tunable properties in pressure-treated two-dimensional Dion–Jacobson perovskites
Authors: Kong Lingping , Liu Gang , Gong Jue , Mao Lingling , Chen Mengting , Hu Qingyang , Lü Xujie , Yang Wenge , Kanatzidis Mercouri G. , Mao Ho-kwang
Published: June 2020

Significance

Two-dimensional Dion–Jacobson (2D D-J) lead-halide perovskite is a cutting-edge material paradigm that has realized high-efficiency photovoltaic applications and synergetic chemical stability. With the addition of the pressure dimension, this material provides a crucial platform for studying both pressure-tailored physical properties and pressure-driven novel phenomena. Here, we demonstrate that 2D D-J perovskites experience various transitions under pressure, such as crystalline-amorphous and 2D–three-dimensional structural transformation, and the probable metallization are strongly suggested. Moreover, the fundamental changes in the material properties are observed at ambient conditions after pressure treatment, which is crucial for achieving the desired characteristics for viable applications.
Bioclickable and mussel adhesive peptide mimics for engineering vascular stent surfaces
Authors: Yang Zhilu , Zhao Xin , Hao Rui , Tu Qiufen , Tian Xiaohua , Xiao Yu , Xiong Kaiqing , Wang Miao , Feng Yonghai , Huang Nan , Pan Guoqing
Published: June 2020

Significance

An ideal metal vascular stent has multiple properties for successful reendothelialization. These properties include 1) inhibiting thrombosis by preventing platelet activation/adhesion, 2) suppressing smooth muscle cell migration/proliferation, and 3) accelerating endothelial cell migration/proliferation. With an easy-to-perform, two-step surface bioengineering approach, the multifunctionalized stents reported here contain two vasoactive moieties (i.e., the nitric-oxide-generating organoselenium and the endothelial progenitor cell-targeting peptide) to satisfy all requirements. The surface engineering strategy presented here can be translated into clinical coatings for cardiovascular stents and will benefit enormously and globally the cardiovascular disease patients; it will, moreover, offer insights to engineering surfaces of blood-contacting devices.
Proximal threats promote enhanced acquisition and persistence of reactive fear-learning circuits
Authors: Faul Leonard , Stjepanović Daniel , Stivers Joshua M. , Stewart Gregory W. , Graner John L. , Morey Rajendra A. , LaBar Kevin S.
Published: June 2020

Significance

Traditional laboratory-based fear-conditioning approaches are often limited in their generalizability to real-world encounters where threats are dynamic and embedded in contextually rich environments. Moreover, while spatial distance to a threat organizes defensive responses, our understanding of the neurobehavioral mechanisms relating proximity and fear learning is lacking. To address these limitations, we developed a three-dimensional (3D) virtual reality simulation that provides a more ecologically valid examination of how threat proximity influences the learning and memory of fear associations. Our findings highlight that threats invading peripersonal space persist longer in memory and uniquely recruit a reactive neural fear system, which has important clinical implications for understanding how near-body traumatic experiences exacerbate the development of traumatic stress disorders.
The influence of packing structure and interparticle forces on ultrasound transmission in granular media
Authors: Zhai Chongpu , Herbold Eric B. , Hurley Ryan C.
Published: June 2020

Significance

Structure-property relations of granular materials are governed by the arrangement of particles and the chains of forces between them. These relations enable design of wave damping materials and nondestructive testing technologies. Wave transmission in granular materials has been extensively studied and demonstrates rich features: power-law velocity scaling, dispersion, and attenuation. However, the precise roles of particle arrangements and force chains on these features remain topics of continued research interest. Here, we employ X-ray measurements and analyses to show that velocity scaling and dispersion arise from both particle arrangements and force chains, while attenuation arises mainly from particle arrangements.
Yeast mannan increases Bacteroides thetaiotaomicron abundance and suppresses putrefactive compound production in in vitro fecal microbiota fermentation
Authors: Oba Shunsuke , Washida Kazuto , Shimada Yu , Sunagawa Tadahiro , Tanihiro Reiko , Sugiyama Hiroshi , Nakamura Yasunori
Published: June 2020

Yeast mannan is a part of yeast cell wall and can potentially affect gut microflora as a soluble dietary fiber. We demonstrated that yeast mannan suppressed putrefactive production and increased the relative abundance of Bacteroides thetaiotaomicron in in vitro fecal fermentation. These results suggest that yeast mannan can be used as a novel prebiotic food ingredient.
Liquid–liquid phase separation in autophagy
Authors: Noda Nobuo N. , Wang Zheng , Zhang Hong
Published: June 2020

Liquid–liquid phase separation (LLPS) compartmentalizes and concentrates biomacromolecules into distinct condensates. Liquid-like condensates can transition into gel and solid states, which are essential for fulfilling their different functions. LLPS plays important roles in multiple steps of autophagy, mediating the assembly of autophagosome formation sites, acting as an unconventional modulator of TORC1-mediated autophagy regulation, and triaging protein cargos for degradation. Gel-like, but not solid, protein condensates can trigger formation of surrounding autophagosomal membranes. Stress and pathological conditions cause aberrant phase separation and transition of condensates, which can evade surveillance by the autophagy machinery. Understanding the mechanisms underlying phase separation and transition will provide potential therapeutic targets for protein aggregation diseases.
Large Dynamical Axion Field in Topological Antiferromagnetic Insulator Mn2Bi2Te5
Authors: Zhang Jinlong , Wang Dinghui , Shi Minji , Zhu Tongshuai , Zhang Haijun , Wang Jing
Published: June 2020

The dynamical axion field is a new state of quantum matter where the magnetoelectric response couples strongly to its low-energy magnetic fluctuations. It is fundamentally different from an axion insulator with a static quantized magnetoelectric response. The dynamical axion field exhibits many exotic phenomena such as axionic polariton and axion instability. However, these effects have not been experimentally confirmed due to the lack of proper topological magnetic materials. Combining analytic models and first-principles calculations, here we predict a series of van der Waals layered Mn2Bi2Te5-related topological antiferromagnetic materials that could host the long-sought dynamical axion field with a topological origin. We also show that a large dynamical axion field can be achieved in antiferromagnetic insulating states close to the topological phase transition. We further propose the optical and transport experiments to detect such a dynamical axion field. Our results could directly aid and facilitate the search for topological-origin large dynamical axion field in realistic materials.
Ferromagnetic MnSn Monolayer Epitaxially Grown on Silicon Substrate
Authors: Yuan Qian-Qian , Guo Zhaopeng , Shi Zhi-Qiang , Zhao Hui , Jia Zhen-Yu , Wang Qianjin , Sun Jian , Wu Di , Li Shao-Chun
Published: June 2020

Two-dimensional (2D) ferromagnetic materials have been exhibiting promising potential in applications, such as spintronics devices. To grow epitaxial magnetic films on silicon substrate, in the single-layer limit, is practically important but challenging. In this study, we realized the epitaxial growth of MnSn monolayer on Si(111) substrate, with an atomically thin Sn/Si(111)-

2

3

×
2

3

-buffer layer, and controlled the MnSn thickness with atomic-layer precision. We discovered the ferromagnetism in MnSn monolayer with the Curie temperature (T
c) of ∼ 54 K. As the MnSn film is grown to 4 monolayers, T
c increases accordingly to ∼ 235 K. The lattice of the epitaxial MnSn monolayer as well as the Sn/Si(111)-

2

3

×
2

3

is perfectly compatible with silicon, and thus an sharp interface is formed between MnSn, Sn and Si. This system provides a new platform for exploring the 2D ferromagnetism, integrating magnetic monolayers into silicon-based technology, and engineering the spintronics heterostructures.
Dose-optimised chest computed tomography for diagnosis of Coronavirus Disease 2019 (COVID-19) – Evaluation of image quality and diagnostic impact
Authors: Steuwe Andrea , Rademacher Christin , Valentin Birte , Köhler Marie-Helen , Appel Elisabeth , Keitel Verena , Timm Jörg , Antoch Gerald , Aissa Joel
Published: June 2020

Objectives. The detection of Coronavirus Disease 2019 (COVID-19) by reverse transcription polymerase chain reaction (RT-PCR) has varying sensitivity. Computed tomography (CT) of the chest can verify infection in patients with clinical symptoms and a negative test result, accelerating treatment and actions to prevent further contagion. However, CT employs ionising radiation. The purpose of this study was to evaluate protocol settings, associated radiation exposure, image quality and diagnostic performance of a low-dose CT protocol in a university hospital setting. Materials and Methods. Chest CT examinations were performed on a single scanner (Somatom Definition Edge, Siemens Healthineers, Germany) in 105 symptomatic patients (60 male, 45 female). Images were evaluated with regard to protocol parameters, image quality, radiation exposure and diagnostic accuracy. Serial RT-PCR served as the standard of reference. Based on this reference standard sensitivity, specificity, positive and negative predictive values of CT with 95% confidence interval were calculated. Results. The mean effective dose was 1.3 ± 0.4 mSv (0.7–2.9 mSv) for the patient cohort (mean age 66.6 ± 16.7 years (19–94 years), mean body mass index (BMI) 26.6 ± 5.3 kg m−2 (16–46 kg/m2)). A sensitivity of 100 [95% CI: 82–100]%, a specificity of 78 [95% CI: 68–86]%, a positive predictive value of 50 [95% CI: 33–67]% and a negative predictive value of 100 [95% CI: 95–100]% were obtained. No COVID-19 diagnoses were missed by CT. Image noise did not strongly correlate with BMI or patient diameter and was rated as average. Conclusions. We presented a robust imaging procedure with a chest CT protocol for confident diagnosis of COVID-19. Even for an overweight patient cohort, an associated radiation exposure of only 1.3 ± 0.4 mSv was achieved with sufficient diagnostic quality to exclude COVID-19.
Stretching and heating cells with light—nonlinear photothermal cell rheology
Authors: Huster Constantin , Rekhade Devavrat , Hausch Adina , Ahmed Saeed , Hauck Nicolas , Thiele Julian , Guck Jochen , Kroy Klaus , Cojoc Gheorghe
Published: June 2020

Stretching and heating are everyday experiences for skin and tissue cells. They are also standard procedures to reduce the risk for injuries in physical exercise and to relieve muscle spasms in physiotherapy. Here, we ask which immediate and long-term mechanical effects of such treatments are quantitatively detectable on the level of individual living cells. Combining versatile optical stretcher techniques with a well-tested mathematical model for viscoelastic polymer networks, we investigate the thermomechanical properties of suspended cells with a photothermal rheometric protocol that can disentangle fast transient and slow ‘inelastic’ components in the nonlinear mechanical response. We find that a certain minimum strength and duration of combined stretching and heating is required to induce long-lived alterations of the mechanical state of the cells, which then respond qualitatively differently to mechanical tests than after weaker/shorter treatments or merely mechanical preconditioning alone. Our results suggest a viable protocol to search for intracellular biomolecular signatures of the mathematically detected dissimilar mechanical response modes.
The utilization of cassava by-products as complete feed on physical and chemical meat quality of weaning male crossbred Landrace pigs
Authors: Hasan F , Zendrato D P , Hanafi N D , Sadeli A , Daulay A H
Published: June 2020

The objective of this research is utilization of cassava by-products as complete ration on physical and chemical meat quality of weaning male of crossbred Landrace pigs. This research was conducted at Desa Rumah Mbacang Pancur Batu from April to June 2019. The research used completely randomized design (CRD) with 4 treatments and 2 replications. The treatments compose of P0 (without cassava by-products), P1 (with 20% cassava by-products), P2 (with 40% cassava by-products) and P3 (with 60% cassava by-products). The variables were observed consist of physical quality (pH value, water holding capacity, cooking loss and color) and chemical quality (water content, fat content and protein content). The results showed that the best pH value on P1 (5.00), the best water holding capacity on P1 (51.32%), best cooking loss on P1 (44.99%), the best color on P1 (1.50), the best water content on P1 (78.11%), the best fat content on P1 (3.84%) and the best protein content on P1 (21.72%). It was concluded that the use of cassava by-products in complete feed for pigs should not exceed 20%.
Sustainable Manufacturing that is Environmentally Friendly
Authors: Sembiring N , Tambunan M M , Ginting E
Published: June 2020

Sustainable Manufacturing is becoming a hot issue among companies in Indonesia. Sustainable Manufacturing itself has the meaning of an effort to develop the concept of a sustainable Manufacturing Industry. This concept is considered very necessary to be developed in order to maintain the sustainability of natural resources on earth. The concept of Sustainable Manufacturing has three important aspects, namely economic aspects, social aspects and environmental aspects. The economic aspect is the company’s efforts to keep developing and continue to generate commercial profits, while the social aspect is the company’s effort to provide reciprocity to the local residents. The last aspect is the most important aspect, which is the environment. In protecting the environment, some parameters in manufacturing company such as efficiency material, minimization waste, efficiency resource must be as a priority awareness.
Porous Ceramic As Basic Contruction Material Based Passive Cooling Clay Mixed With Charcoal Candlenut Shell (AleuritesMoluccana)
Authors: Sitorus Z , Anisah F , Fauzi
Published: June 2020

It has been made of porous ceramics made of clay with a mixture of candlenut shell activated charcoal through conventional techniques of printing and presses the clay composition variation: activated charcoal shell candlenut 100: 0, 90:10, 80:20, 70:30, 60:40, 50: 50 grams. Clay and activated charcoal candlenut shells sifted with a particle size of 100 mesh. Clay and activated charcoal powder candlenut shells which have been mixed printed by the dry pressing method with the pressure of 5 tons was detained for 10 minutes. Then the beam-shaped sample was burned with a combustion temperature of 900°C and held for 3 hours. Each sample is characterized that include: physical properties (porosity, water absorption, and surface morphology), mechanical properties (hardness, compressive strength, and XRD) and thermal properties (DTA). The results showed that variations in the composition of clay: candlenut shell activated charcoal optimum at 50: 50-gram composition with 66.20% porosity; water absorption value of 69.42%; 298.19 Mpa hardness values; 6,75Mpa value of the compressive strength and optimum pore diameter 1.0785 μm with oxygen element content of 51.76%. The XRD results showed the addition of activated charcoal on a pecan shell does not form a porous ceramic crystallinity, and from the graph shows that the dominant crystal structure is monoclinic. DTA testing results 70°C and temperature endothermic temperature eksoterm450°C. The XRD results showed the addition of activated charcoal on a pecan shell does not form a porous ceramic crystallinity, and from the graph shows that the dominant crystal structure is monoclinic. DTA testing results 70°C and temperature endothermic temperature eksoterm450°C. The XRD results showed the addition of activated charcoal on a pecan shell does not form a porous ceramic crystallinity, and from the graph shows that the dominant crystal structure is monoclinic. DTA testing results in endothermic temperature 70°C and exotherm temperature 450°C.
On Using The First Variant of Dependent RSA Encryption Scheme to Secure Text: A Tutorial
Authors: Rachmawati D , Budiman M A
Published: June 2020

The Rivest-Shamir-Adleman (RSA) public key cryptosystem has been extensively used to secure digital communication since more than forty years. The security of RSA relies on the hardness of factoring a big integer into its two big prime factors: the bigger the integer, the securer the cryptosystem. However, the RSA cryptosystem is proven to be not semantically secure. Some variants of Dependent RSA encryption schemes have been introduced by Pointcheval to overcome this problem. This study shows how the first variant of Dependent RSA (DRSA-1) encryption scheme is used to secure text. All algorithms have been implemented in the Python programming language version 2.7.15.
Design of a Continuous Coffee Bean Solar Dryer
Authors: Ambarita H , Munthe H K J , Hutagalung T
Published: June 2020

As one of the renewable energy that can be utilized in various fields, solar energy is a potential energy source considering that Indonesia has a tropical climate. One of the uses of solar energy is in agriculture. Various agricultural commodities need to be dried before further processing. Also in coffee commodities that are being favored by many people nowadays. For this reason, as a solution to the problem of long drying times with weather changes issue, a room is made as a drying medium. By sucking hot air from a 2.576 m2 solar collector using the exhaust, it is expected that heat will be maintained in the space that has been isolated. The 2.4 m2 dryer rack design is made in three trays to make the most of the space. The results of the room that have been made is able to keep the lowest temperature at night at 26.6 °C and the highest temperature at 60.7 °C during the day. The highest average temperature in the room is on the bottom shelf near the hot air source.
Provision of Complete Feed Fermented Peel Cassava (Manihot esculenta Crantz) Male Kacang Goat Performance
Authors: Tafsin M , Hanafi N D , Sadeli A , Hamdan  , Sari S F
Published: June 2020

Complete feed fermented cassava peel is a feed ingredient that is considered potential to support the performance of Male Kacang Goat. This research was conducted in Sihopuk Baru Village, Halongonan Timur District, Padang Lawas Utara Regency. Maintenance was carried out for three months, from April to June 2019. The research method was Completely Randomized Design (CRD) with 4 treatments and 3 replications so that there were 12 male goats maintained. P0: Complete feed 75% fermented cassava dried+ 0% cassava peel, P1: complete feed 55% fermented cassava dried + 20% cassava peel, P2: complete feed fermentation 35% cassava dried + 40% cassava peel, P3: complete feed 15% fermented cassava dried + 60% cassava peel. The research parameters are Feed Consumption, Weight gain, and Feed Conversion. The average feed consumption of Kacang goat is P0 of 274.67; P1 of 277.64; P2 of 277.63; and P3 of 279.33. The average weight gain kacang goat is P0 of 12.70 g / head / day; P1 of 18.33 g / head / day; P2 of 34.66 g / head / day; and, P3 of 27.33 g / head / day. The average conversion of kacang goat feed is P0 of 21.98; P1 of 15.43; P2 of 8.38; and P3 of 10.23. P2 is a formula complete feed fermented cassava peel which is best for supporting the performance of kacang goats.
Preparation and Characterization of Coconut Oil Based Soap with Kaolin as Filler
Authors: Iriany  , Sukeksi L , Diana V , Taslim
Published: June 2020

Soap is the product of saponification of fats with a base, which is used as a body cleanser, in the form of solid, foamy, with or addition of other ingredients and do not cause skin irritation. Clay (kaolin) is used as an active ingredient in cosmetics because of the high level of adsorption of substances such as oil, toxins, and others. The use of clay also been considered as a potential tanning agent in halal industrial applications. This study aimed to search for the effect of temperature reaction and addition of kaolin to the solid soap produced. The saponification reactions was carried out for 10 minutes in a reaction flask at a temperature that varied from 50ºC - 80ºC. The beginning stage was to heat the coconut oil to the reaction temperature and then mixed it with kaolin (10%, 12.5%, 15%, 17.5%, 20% wt.), followed by adding 35% NaOH. The reaction mixture was stirred at 250 rpm. The results of this study showed that all soap products met the Indonesia standard SNI.
Stability analysis of heartbeat system with lyapunov’s direct method
Authors: Tulus  , Siahaan L O , Marpaung T J , Syahputra M R
Published: June 2020

The heart is a very vital organ. There are two main states in the heartbeat cycle, systole and diastole. The heartbeat system studied in this paper was taken from a study of Thanom and Loh in 2011. This paper is aimed to analyze the stability of the heartbeat system using Lyapunov’s Direct Method. This method requires a Lyapunov function. To construct the Lyapunov function, the Gradient Variable Method will be used. In this research, the Lyapunov function constructed

V
(
x
)
=

x
1
2

+

x
2
2

,

V
˙

(
x
)
>
0

is obtained. This means

V
˙

(
x
)

is said to be a positive definite and the equilibrium point (0,0) of the heartbeat system is unstable.
The Correlation Between Mangroves and Coastal Aquatic Biota
Authors: Onrizal O , Desrita  , Ahmad A G , Thoha A S
Published: June 2020

Mangrove forests are important for the productivity of estuary ecosystems, including diversity and population of coastal biota because of their contribution through the fall of litter so that mangroves as the first chain of tropical chains on the coast. Most of marine biota species are thought to be highly dependent on mangrove areas from west to east tropical region. About 70% of fish caught were only found in mangrove forests that were still good. The fish population and species in healthy mangroves were 159-234% and 116-129% greater than mangrove forests that have been degraded, respectively. The loss and degradations of mangroves also causes fishermen income to decrease. Therefore, the healthy mangrove should be maintained with properly management as well as the degraded mangrove should be restored based on scientific basis. Conserving and restoring mangroves are becoming a very productive investment, not only for the present generation, but also for future generations.
Without research, no community service
Authors: Nasution Mahyuddin K M , Tulus  , Munir Erman , Onrizal
Published: June 2020

Research is the duty of universities in addition to education. Meanwhile, the community service is a different task, but it becomes a bridge is to downstream both of them. This paper intends to describe the relationship between research and community service, which implies that prior to servicing the community, a necessity of its implementation requires research, to ensure that community service fulfils the achievement targets.
The Effect of Palm Oil Planting Material Characteristics on the Population of Weevil Pollinator (Elaeidobius kamerunicus)
Authors: Wahyuni M , Wagino  , Manurung H
Published: June 2020

The productivity of oil palm plants is determined by the success of pollination. Some factors that influence are the planting material, rainfall conditions and the adequacy of pollinating weevil, namely Elaeidobius kamerunicus (EK). Producers of planting materials produce crosses of Dura X Pisifera hybrids with their spesific characters. This research aim was to determine the effect of planting material on flowering characteristics and EK population.The research was conducted in Adolina (DxP Simalungun) and Dolok Ilir (DxP La Me) in January 2018 - October 2018 with a descriptive method. The research results showed that the character of oil palm planting material affected the number and character of male flowers as a source of pollen.In planting material with a large number of male flower spikelet, the DxP Simalungun has a positive effect on the population of Elaedobius kamerunicus. The efforts to increase the EK can be achieved by applying the Hatch and Carry technique which can increase EK populations by 32-45%.
Response of Soil Microbial Biomass Carbon, Nitrogen and Enzyme Activity to Sophora Davidii Skeels and Pennisetum Sinese Roxb Intercropping Systems
Authors: Zhang Yujun , Shang Yishun , Wang Puchang , Zou Chao , Ding Leilei , Zhang Wen , Yang Fuli , Tang Huajiang , Liu Jiajia
Published: June 2020

To understand the response mechanism of soil microbial biomass carbon content, soil microbial biomass nitrogen content and soil enzyme activities to intercropping pattern, an experiment consisting of three cropping patterns: Sophora davidii Skeels monocropping pattern, Pennisetum sinese Roxb monocropping pattern and S. davidii and P. sinese intercropping pattern had established in the southern region of Guizhou Province, China. The results showed that soil microbial biomass carbon content, microbial biomass nitrogen content and enzyme activities were gradually reduced with the depth (0-30 cm) of the soil layer increased under the three cropping patterns. The microbial biomass carbon and nitrogen content of S. davidii and P. sinese intercropping pattern were significantly higher than those of S. davidii monocropping and P. sinese monocropping pattern in 0-20 cm soil layer (P <0.05). Five soil enzyme activities were ranked: P. sinese monocropping > S. davidii and P. sinese intercropping > S. davidii monocropping in most soil layers. The soil nutrient contents (soil organic matter, total nitrogen, total phosphorus, and total potassium) and soil microbial biomass content (microbial biomass carbon and nitrogen) were highly significant positive correlation (P <0.01), while five soil enzyme activities had a significant positive correlation with each other (P <0.05). However, there was no significant correlation between soil microbial biomass content and soil enzyme activities. Additionally, there was non-significant correlation between the activiies of nitric oxide synthetase, the activiies of β-N-acetylglucosidase and the activiies of leucine aminopeptidase (P> 0.05), but the activiies of β-N-acetylglucosidase, the activiies of soil nitrogenase, the activiies of soil Leucine aminopeptidase and the activiies of soil glutamine synthetase were showed a significant (P <0.05) or very significant positive correlation (P <0.01). In summary, the intercropping pattern of S. davidii and P. sinese has a significant effect on soil quality improvement in shallow soil (0-20cm), and the microbial biomass carbon, soil microbial biomass nitrogen and soil enzymes can be used as an important index for evaluating the changes of soil quality.
Exploration and Application of Resilience Theory in Land Consolidation Engineering
Authors: Xiong Yufei
Published: June 2020

Incorporating the theory of resilience into land remediation is an inevitable requirement of the development of the times. This paper explores the combination and application of resilience theory in land remediation projects through literature analysis and logical reasoning, and proposes the planning and design of land remediation. Relying on the theory of resilience, we should explore the theory of resilience and the direction of land rectification under the development of the times.
Determination of Heavy Metals in the Plant Sample Pretreatment Methods
Authors: Gong Li , Qiu Dongping , Yao Xusong , Yang Gang
Published: June 2020

In this paper, dry ashing method, mixed acid nitration (H2SO4-H2O2), three acid digestion (HNO3-H2SO4-HClO4) and aqua-regia-HClO4 these four test solution preparation method on the decomposition of plant standards GBW07603 processing, use atomic absorption spectrophotometry Zn, Cu, Pb, Fe, Cd, Cr six kinds of metal elements, and the measured values compared with the standard value. The results showed that after dry ashing recoveries higher than Zn recovery after acid digestion; Cu determination should not use dry ashing; Pb determination should not be used mixed acid nitration (H2SO4-H2O2) or tri-acid digestion method (HNO3-H2SO4-HClO4);dry ashing treatment after acid digestion Cr yield higher Cr recoveries. Comprehensive analysis of the low carbon content of the metal elements in plant samples (Zn, Cu, Pb, Fe, Cd, Cr) of the measurement, can be aqua-regia-HClO4 pretreatment method, and for comparing the carbon content high plant samples should be used as a dry ashing pretreatment method. That is, different pretreatment methods for the determination of different analyte have a certain impact.
Chinese Speech Recognition System based on Deep Learning
Authors: Shao Pengyuan
Published: June 2020

This paper builds a complete Chinese speech recognition system, including acoustic model and linguistic model, which can recognize the input audio signal into Chinese characters. The system realizes the modeling of acoustic model and linguistic model in speech recognition based on deep framework, of which the acoustic model is CNN-CTC and linguistic model is transformer. The data set uses THCHS-30, which refers to 30-hour Chinese speech database of Tsinghua University. The experimental results show that the Chinese speech recognition system based on deep learning achieves 90% accuracy on the test set and has an excellent effect on Mandarin speech recognition in quiet environment.
Study of the Utilization Efficiency and Its Influencing Factors of Water Resources in Yangtze River Economic Belt
Authors: Xu Sichen , Liang Hao
Published: June 2020

The Yangtze River Economic Belt has gradually become one of the regions with the strongest comprehensive strength and the greatest strategic competitiveness in China. Promoting the utilization efficiency of water resources in various provinces and cities in this region and minimizing the restraint effect of insufficient utilization of water resources on the economy can provide strong support for the development of the region from the perspective of water resources. The SBM model was used to measure the water use efficiency of 11 provinces and cities in the Yangtze River Economic Zone from 2007 to 2017 and Tobit model was used to identify the key influencing factors. The results show that the water use efficiency of the provinces and cities in the Yangtze River Economic Zone varies greatly, and the total factor productivity index of water resources shows an overall growth trend, which is mainly determined by the scale efficiency. The per capita GDP and the proportion of the first industry have a significant positive effect on the water use efficiency, while the government’s investment in water resources and per capita water resources endowment have a significant negative correlation. Based on this, some countermeasures and suggestions are put forward, such as strengthening inter-regional technical cooperation, optimizing water use structure, and reasonably investing in water conservancy facilities projects.
Design of Comprehensive Protection Device for Mine Isolation Lighting Signal
Authors: Long Ma , Qing Chen
Published: June 2020

In order to improve the safety and reliability of underground lighting circuit in coal mine, a comprehensive protection device for mine isolation lighting signal is designed based on the pir-50z intelligent protector. On the basis of the analysis of the status of coal in China’s energy structure and mine production safety situation, the mode of lighting and the role of comprehensive protection device for mine isolation lighting signal and were studied, the detailed design of comprehensive protection device for mine isolation lighting signal hardware circuit and software program was carried out.
CWAO Technology for the Treatment of Refractory-Biodegradable Organic Wastewater
Authors: Zhang Yongxun , Chen Shiqing , Chen Xin , Huang Jieyun , Chen Luoru , Wu Tongtong , Huang Jinming , Liu Yingxin
Published: June 2020

With the development of society and industrial progress, the types and quantity of organic wastewater produced by refractory-biodegradation have increased. As an effective way to treat refractory-organic wastewater, CWAO technology has attracted more and more attention in recent years. The principle of CWAO technology belongs to free radical reaction, which mainly includes two processes: the exchange of oxygen in wastewater and the reaction between liquid oxygen and contaminants supported on the catalyst. Free radical reactions include three specific processes: chain initiation, chain delivery and chain termination. Homogeneous CWAO reaction can efficiently treat high concentration of organic wastewater, but the catalyst cannot be recovered to form secondary pollution. Heterogeneity is the research hotspot of CWAO technology and a suitable means for the treatment of highly concentrated organic wastewater, which has been used more and more in printing and dyeing, pharmaceutical, chemical, manufacturing and other industries.
Capability of Several Marine Active Substances to Eliminate Hydroxyl Radicals
Authors: Zhang Yongli
Published: June 2020

Using hydroxyl radicals as an in vitro antioxidant model and using ascorbic acid (Vc) as a positive control, four important marine activities of trehalose, carboxymethyl chitosan, glucosamine hydrochloride, and rippled paphia small molecule peptide were studied Antioxidant ability of the substance in vitro. The experimental results show that the four marine active substances have good antioxidant properties, and their antioxidant properties show a certain positive correlation with the concentration; carboxymethyl chitosan has a stronger ability to eliminate hydroxyl radicals than the other three marine active substances. When the concentration was 4g/L, the elimination rate of para-hydroxyl radicals reached 91.71%.
Research on Reverse Supply Chain under O2O Classified Recovery Mode
Authors: Hong Li , Chen Wenjuan
Published: June 2020

In recent years, due to the continuous growth of social needs and the continuous innovation of science and technology, the demand for various products has grown rapidly. Fierce market competition has accelerated the upgrading of various products, resulting in a shortened product life cycle and a large number of obsolete products. At the same time, the development of the Internet has brought a new path for recycling-the O2O classification recycling model, which simplifies the product recycling path from consumers to manufacturers. Therefore, research based on the O2O classification recovery model has become the key to solving the waste product recovery.
Research on Rural Landscape Design Based on 3R Principle
Authors: Shi Yi , Wang Yilin , Zai Xiangting , Zeng Yan
Published: June 2020

In recent years, the pace of beautiful countryside construction in China has been accelerating, which has promoted the development of rural tourism industry and is of great significance to the economic development of vast rural areas. While paying attention to economic development, we should also realize the 3R principle, integrate more environmental protection concepts, and realize all-round development in rural areas. Based on the principle of 3R, this paper analyzed the rural landscape design, optimized the traditional design methods, selected more green recyclable materials, and improved the economic benefits of rural landscape design and environmental protection benefits, which provides power for the long-term development of rural areas.
Suitability of Recuperation Industry Development——A Case Study of Sichuan Province, China
Authors: Tang Jin , Wu Haoyue , Luo Luxi , Fu Gang
Published: June 2020

As an emerging industry, the development of recuperation industry is quite promising, and it’s becoming an important support to the transformation of resource-oriented cities, the integration of primary, secondary and tertiary industries in rural areas, and the development of new industries and new businesses in China. In this paper, the studies related to recuperation industry are reviewed, after which the theory of “6+1” is adopted into use for building a comprehensive index system to evaluate the suitability of development of recuperation industry. The results show that places including Chengdu, Liangshan, Panzhihua, Mianyang, Nanchong and Guangyuan are appropriate for developing recuperation industry. Among them, the advantages in supporting facilities of Chengdu lay a good foundation for the development of recuperation industry; sunshine-based and forest-based recuperation suites Panzhihua better; and highland-based recuperation suites Yi Autonomous Prefecture of Liangshan. Places including Suining, Neijiang, Zigong, Aba and Garze are not appropriate for developing recuperation industry. The measurement results, with the development reality of Sichuan considered, provides some references for the development of recuperation industry in Sichuan in future.
Research on Industrial Landscape Reconstruction Design of Baoji Shenxin Yarn Factory
Authors: Qiao Zhi , Hui Dan , Huang Jingfan
Published: June 2020

This paper is devoted to the study of industrial heritage landscape reconstruction from the perspective of cultural memory. Taking the industrial landscape reconstruction design of Baoji Shenxin Yarn Factory as an example, the historical value will be excavated and extended in all directions. Combining the traditional concept of industrial heritage, historical and cultural status, site composition and development trend, the stage industrial heritage will be presented. The problems existing in the landscape renovation, and systematic analysis, elaboration and summary of the overall environmental characteristics of Shenxin Yarn Factory. This research combines the heritage itself with landscape planning and design, comprehensively utilizes the advantages of industrial heritage resources in combination with the design principles of protection, harmony and utilization, and combines with the development of sustainable tourism to protect the construction and art of China’s industry and achieve industrialization. The value of the heritage is maximized, and the trinity of heritage landscape, economy and environment is coordinated towards the diversification of ecological, functional, practical, economic, cultural and aesthetic.
Research on Flight Trajectory Optimization Based on Quantum Genetic Algorithm
Authors: Li Yibo , Qin Shuaitao , Jing Lei
Published: June 2020

Taking the passenger aircraft A320 as the research object, the trajectory optimization of the aircraft climbing section under wind disturbance is carried out. Through the analysis of the aircraft’s descent process, the kinematics model, fuel consumption model and atmospheric model of the aircraft are established, and the objective function and constraints of the problem are obtained. The quantum genetic algorithm is used to transform the optimal control problem into a nonlinear programming problem. The optimal trajectory of the aircraft’s shortest descent time is obtained by simulation. The effects of different cost indices on the fall time and fuel consumption are discussed.