bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparative evaluation of combined and traditional (suture) methods of amnion fixation in surgical treatment of persistent corneal erosion
Authors:   S.M. Kirov Military Medical Academy of the Ministry of Defense, Churashov S.V. , Chernysh V.F. ,   S.M. Kirov Military Medical Academy of the Ministry of Defense, Karpovich V.V. ,   S.M. Kirov Military Medical Academy of the Ministry of Defense, Kozlova Y.V. ,   S.M. Kirov Military Medical Academy of the Ministry of Defense, Bogdanov V.A. ,   S.M. Kirov Military Medical Academy of the Ministry of Defense
Published: February 2025

Purpose. to compare the traditional suture and combined methods of amniotic membrane (AM) fixation during the surgical treatment of persistent corneal erosion (PER).

Material and methods. The study was carried out on 50 patients (54 eyes). All eyes were divided into 2 groups: experimental (combined method of AM fixation using sutures and two-component autofibrin glue (DAPK)) and control (fixation with sutures). A comparative assessment was carried out: the period of AM lysis, the area of corneal epithelium defects before and after surgery, the presence/absence of OCT signs of inadequate adhesion of AM to the ocular surface, the quality and comfort of the surgical manual based on the results of the surgeons' questionnaire.

Results. Before the start of surgical treatment of PER, the mean area of erosion in the study group was 27.5 (19.3; 32.8) mm2, in the control group — 32.6 (20.5; 36.5) mm2, the main causes of PER: corneal injuries and burns, high-risk keratoplasty, PER after repeated vitreoretinal interventions. The compared groups were homogeneous in these characteristics. The average duration of operations in the study group was 19 (17; 21) minutes, in the control group — 30 (25; The mean period of AM lysis in the study group was 10 (9; 12) days, in the control group — 7 (7; 9) days. The area of erosion in the study group at the end of treatment was 4.3 (2.4; 5.3), in the control group — 9.7 (7.5; 12.8). The formation of AM folds was observed only in the control group (in 40 % of cases). Incomplete adhesion of AM to the ocular surface in the study group was observed in 15.3 % of cases, in the control group — in 53.3 %.

Conclusion. The study showed not only the possibility, but also the significantly higher clinical efficacy, convenience and reliability of the proposed combined method of fixation of AM to the ocular surface in the treatment of persistent corneal erosions of various etiologies.

Keywords: persistent corneal erosion, amniotic membrane, methods of amniotic membrane fixation
Going nuclear: Improved antisense oligonucleotide activity through conjugation with a nuclear importer
Authors: Kashyap Disha , Milne Thomas , Booth Michael
Published: February 2025

Antisense oligonucleotides (ASOs) are a promising class of therapeutics designed to modulate gene expression. Both key mechanisms of action for ASOs operate in the nucleus: splice-switching ASOs modify pre-mRNA, processed in the nucleus, and mRNA-degrading ASOs require RNase H, an enzyme predominantly active in the nucleus. Therefore, to achieve maximal efficacy, ASOs require efficient nuclear delivery. Current ASO therapeutics shuttle in and out of the nucleus inefficiently. In this work, we have synthesised ASO conjugates for active nuclear import, by covalent conjugation with a potent small-molecule nuclear importer, (+)-JQ1. (+)-JQ1 is a well-characterised high-affinity binder for members of the BET bromodomain family of proteins and was recently shown to transport cytoplasmic proteins into the nucleus. Our (+)-JQ1-ASO conjugates outperformed their unmodified counterparts for both splice-switching and mRNA knockdown in the nucleus. In particular, we improved the performance of Oblimersen, a BCL-2 ASO drug that failed phase-III clinical trials, showing that this therapeutic may merit re-evalutaion. This work shows that the covalent modification of ASOs with a small-molecule nuclear importer can significantly improve target engagement and pave the way for more effective therapeutics.
Modular, Three-Component and Concurrent One-Pot Libraries of γ-Keto Sulfones and γ-Keto Phosphine Oxides. Brønsted Acidic Eutectic Mixtures Are the Answer
Authors: Ramos-Martín Marina , García-Álvarez Joaquín , Presa Soto Alejandro
Published: February 2025

A modular, three-component, and sustainable one-pot/one-step protocol has been developed for the efficient and regioselective synthesis of libraries of γ-keto sulfones and γ-keto phosphine oxides through concurrent C-C and C-X bond formation (X = S or P). The acidic eutectic mixture ChCl/p-TSA·H2O (1:2) (ChCl = choline chloride; p-TSA = p-toluenesulfonic acid) serves as both promoter and reaction medium. This transformation involves a cascade process comprising three consecutive steps: i) hydration of terminal alkynes to methyl ketones; ii) Claisen-Schmidt condensation with aldehydes, and iii) Sulfa-Michael or Phospha-Michael additions using sodium sulfinates or secondary phosphine oxides, respectively. The methodology provides high yields (up to 99%), excellent atom economy, and operational simplicity, as the products are isolated without the use of any toxic volatile organic solvents (VOCs) or tedious chromatographic purification. Its modular nature accommodates a broad range of substrates, including electron-rich and electron-deficient components, demonstrating robustness and versatility (112 examples). Furthermore, the protocol enables scalable (ten-fold) and recyclable (3 cycles) synthesis of biologically relevant γ-keto derivatives under green conditions (E-factor ≤ 10), offering a general strategy for sustainable and modular C-C and C-X bond-forming reactions.
AlphaFold2-RAVE: Protein Ensemble Generation with Physics-Based Sampling
Authors: Teng Da , Meraz Vanessa J. , Aranganathan Akashnathan , Gu Xinyu , Tiwary Pratyush
Published: February 2025

We introduce AlphaFold2-RAVE (af2rave), an open-source Python package that integrates machine learning-based structure prediction with physics-driven sampling to generate alternative protein conformations efficiently. Protein structures are not static but exist as ensembles of conformations, many of which are functionally relevant yet challenging to resolve experimentally. While deep learning models like AlphaFold2 can predict structural ensembles, they lack explicit physical validation. af2rave addresses this limitation by combining reduced multiple sequence alignment (MSA) AlphaFold2 predictions with molecular dynamics (MD) simulations to efficiently explore local conformational space. A feature selection module identifies key structural degrees of freedom, and the State Predictive Information Bottleneck (SPIB) method uncovers the underlying conformational topology, classifying functionally relevant states. Under the Reweighted Autoencoded Variational Bayes for Enhanced Sampling (RAVE) protocol, either unbiased or biased sampling can be performed to further explore the conformation ensembles. We validate af2rave on multiple systems, including E. coli adenosine kinase (ADK) and human DDR1 kinase, successfully identifying distinct functional states with minimal prior biological knowledge. Furthermore, we demonstrate that af2rave achieves conformational sampling efficiency comparable to long unbiased MD simulations on the SARS-CoV-2 spike protein receptor-binding domain while significantly reducing computational cost. The af2rave package provides a streamlined workflow for researchers to generate and analyze alternative protein conformations, offering an accessible tool for drug discovery and structural biology.
Administración pública, mitigación de la pobreza y gobernabilidad democrática: una vinculación necesaria
Authors: ARGYRIADES Demetrios
Published: February 2025

Asistimos al surgimiento de un nuevo perfil de la pobreza en varias partes del mundo. Más allá de los síntomas conocidos de la pobreza, independientemente de si estos conocimientos son absolutos o relativos, en muchas regiones se enfrentan los fenómenos de exclusión, aumento de privilegios de unos cuantos sobre los muchos, inequidad, inseguridad y marginalización de residentes afectados por la pobreza e inmigrantes en una escala alarmante. Estos fenómenos son todavía difíciles de predecir pero en general apuntan a un visible aumento del extremismo, religioso y político, con presagios ominosos. Sólo tenemos que mirar hacia las áreas de conflicto armado que cada vez están más cerca de casa.
Administración pública, mitigación de la pobreza y gobernabilidad democrática: un vínculo necesario
Authors: ARGYRIADES Demetrios
Published: February 2025

Asistimos al surgimiento de un nuevo perfil de la pobreza en varias partes del mundo. Más allá de los síntomas conocidos de la pobreza, independientemente de si estos conocimientos son absolutos o relativos, en muchas regiones se enfrentan los fenómenos de exclusión, aumento de privilegios de unos cuantos sobre los muchos, inequidad, inseguridad y  marginalización de residentes afectados por la pobreza e inmigrantes en una escala alarmante. Estos fenómenos son todavía difíciles de predecir pero en general apuntan a un visible aumento del extremismo, religioso y político, con presagios ominosos. Sólo tenemos que mirar hacia las áreas de conflicto armado que cada vez están más cerca de casa.
Factores determinantes de la innovación del modelo de negocios en la creación de ventaja competitiva
Authors: MEJÍA-TREJO Juan , SÁNCHEZ-GUTIÉRREZ José
Published: February 2025

El presente trabajo, es un estudio documental que describe la importancia de los factores que determinan la innovación del modelo de negocios (IMN) en la creación de ventaja competitiva. Así, la aportación para el lector es presentarle los conceptos básicos de qué es un modelo de negocios, recomendaciones de sostenibilidad, por qué hay modelos de negocios mejores a otros, sus arquetipos desde el punto de vista financiero y de creación de valor para el cliente. Así, se presenta posteriormente, la definición de qué es la IMN, su importancia en la creación de ventaja competitiva, qué lo promueve, cómo se diseña, los diferentes modelos IMN, cómo se implementa, las barreras y su futuro en la adquisición de ventaja competitiva.
Imaginería: ideas relativas a una filosofía de la imaginación como estrategia de enseñanza superior del diseño
Authors: Nava González Carlos Raúl
Published: February 2025

El objetivo de este artículo es mostrar el Diseño Gráfico como una disciplina que deriva en resultados y experiencias que aplican en lo colectivo y en lo individual, por lo que su enseñanza requiere de procesos especiales, y por lo tanto, de especialistas. La docencia en el Diseño no ha sido reconocida como un campo laboral tan válido como la práctica profesional de la disciplina y que per se debe ser desde la enseñanza un proceso innovador,. La magia de la creatividad ha quedado a un lado. Sus fracturas se evidencian más por alejarse de procedimientos y procesos que la innovación y los estudios de la imaginación generan. Estos últimos son procesos más y mejor estructurados, que se aplican en la formación de los profesionistas del diseño. Las diversas teorías sobre la imaginación conllevan estudios de sistemas complejos, de procesos sinápticos, de elementos neuronales, de funciones neurofisiológicas y, los más importantes, de ubicación del origen: la nada.
Toma de decisiones del gobierno para incentivar el crecimiento bajo corrupción no controlada
Authors: Andrade Rosas Luis Antonio , Vega Vladimir
Published: February 2025

Una de las relaciones entre empresas y gobierno se puede establecer a través de un impuesto al capital de las empresas y un gasto hacía ellas por parte del gobierno, equivalente al total de la recaudación. En este trabajo consideramos este gasto de forma incompleta y con ello modelamos nuestra variable corrupción que se genera con el tiempo. Bajo este escenario encontramos la política fiscal óptima que maximiza al crecimiento y probamos que política fiscal puede ser impositiva o subsidiaria de acuerdo a la intensidad de capital. Finalmente, mostramos que la corrupción impacta  de manera negativa a la política impositiva y positivamente a la política subsidiaria.
Relación entre violencia de pareja y estrés parental en población mexicana
Authors: Brito Tinajero Carlos Adrian , Delgadillo Guzmán Leonor Guadalupe , Nievar Angela
Published: February 2025

Esta investigación surge como  producto del convenio de investigación UNT-UAEMéx[1]; con el objetivo de explicar la relación que existe entre la violencia de pareja y el estrés parental en población mexicana a través de las escalas, Escala de Tácticas de conflicto y Escala de estrés parental a 319 madres o mujeres encargadas del cuidado de los niños(as) dentro de los tres primeros años de primaria en educación pública del Estado de México. Se encontró positivamente correlacionada la Violencia de Pareja y el Estrés Parental de manera significativa en todos los factores de ambas escalas (p < 0.01 y p < 0.00). El 89.34% de las participantes reportó haber sufrido al menos un episodio de Violencia de Pareja e índices moderadamente bajos de Estrés Parental.[1] Proyecto de investigación: “Efectos de la violencia de pareja en el desarrollo infantil y la maternidad: Un estudio comparativo entre madres mexicanas y madres hispanas en los Estados Unidos” con clave 3664/2014FS.
CLASIFICACION y RECONOCIMIENTO DE SEÑALES UTILIZANDO LA TECNICA SDP y EL METODO DE ALEXANDER
Authors: González Raggi
Published: February 2025

En la actualidad, con los nuevos avances en la ciencia, se han desarrollado yperfeccionado modelos matemáticos tales como la DFT (Transformada Discreta de Fourier),DHT (Transformada de Hartley), DCT (Transformada Discreta del Coseno), Transformadade Jain, Transformada de Wang y la 02DFT, sin embargo, aunque estos modelos sonbastante poderosos, aún tienen algunos inconvenientes; muchos de estos modelos suelentransformar, una señal cualquiera, del dominio del tiempo, al dominio de la frecuencia, sinembargo, su representación gráfica para el reconocimiento sigue siendo un problema serio.Este trabajo se divide en dos etapas, en la primera presentamos una nueva técnica degraficación que facilita el problema del reconocimiento de señales, que consiste en unamodificación de la información mediante un aumento sistemático por redundancia de laseñal, de tal forma que facilita la manipulación de diferentes parámetros de la señal, por loque se crea un patrón gráfico que es más fácil de analizar.Esta técnicaes en extremo útil para poderrealizarun reconocimientode señales, tanto enel dominio del tiempo como de la frecuencia, ya que con técnicas convensionales degraficación, la clasificación de estas, en patrones, es muy difícil,a diferencia, la técnica SDPayuda a realizar un manejo más práctico de las señales así como a resaltar ciertascaracterísticas de las mismas.En la segunda etapa, con los patrones gráficos ya generados, se clasifican en ,patrones,utilizando el método de Alexander.
A STUDY OF TWELVE SPRING RICE GENOTYPES WITH FARMERS’ PARTICIPATION IN KAILARI VILLAGE, KAILALI, NEPAL
Authors: Subedi S. , Sharma R. , Regmi S.
Published: February 2025

Spring rice (Oryza sativa L.) plays a crucial role as Nepal’s primary staple cereal crop. It has a high potential as an alternative during low rice production in the main season, ensuring food self-sufficiency. A field study was conducted on spring rice at a farmer field school, Kailari Rural Municipality-09, Kailali district, Nepal to identify the best-performing and the most preferred genotypes by the farmers through the participatory approach. The experiment was laid out in randomized complete block design (RCBD) with twelve spring rice genotypes including a local check variety. Each treatment was replicated thrice. Statistically significant differences in yield and yield-attributing traits were observed among the genotypes under observation. Average plant height was recorded as the highest in Hardinath-3 (101.75 cm) followed by IR17L1387 (99.78 cm), Jhumka (98.74 cm), and IR17A3019 (96.55 cm) with the lowest in IR16A3838 (84.79 cm). Similarly, the total number of tillers and effective tillers were found to be the greatest in IR18A1451 and IR17A3019 respectively at harvest. The sterility percentage was lowest in IR17A3012 followed by IR17A3019 whereas highest in Hardinath-4. Similarly, the Hardinath-1 variety matured earlier than, IR16A3838 and IR17A3019. Hardinath-4 variety followed by Jhumka was a late maturing variety. Maximum grain yield was found in IR17A3012 (6.06 t ha-1) which was followed by IR17A3019 (5.97 t ha-1) and superior to the local check variety (Jhumka). Thus, the farmers’ preference score was found to be maximum (0.09) in the IR17A3019 genotype which signifies that this genotype has certain preferable traits such as early and uniform maturity, low disease and pest attack, a high number of effective tillers, panicle length, and sterility percentage.
As diversas formas de amor: Amora, de Natalia Polesso, em tradução
Authors: Hilian Angel Alves , Kahmann Andrea Cristiane
Published: February 2025

Amora (2022 [2015]), uma coleção de contos de Natalia Borges Polesso, foge do que pode ser considerado como “comum” no cenário literário brasileiro, principalmente no contexto da literatura queer, na medida em que traz para o centro da discussão as mulheres e as diferentes vivências relacionadas ao amor lésbico. Embora tenha conquistado muitos dos principais prêmios literários em 2016 e angariado popularidade na comunidade LGBTQIA+, o livro não recebeu atenção da grande mídia brasileira. Diferente foi a trajetória da tradução de Julia Sanches para o inglês dos Estados Unidos e Reino Unido, intitulada Amora: Stories (2020), que reverberou por prestigiados veículos da mídia anglófona. Este artigo, dividido em duas seções, primeiro apresenta a obra e sua autora e tece considerações sobre os impactos no campo da cultura brasileira da ascensão da extrema-direita; depois, analisa aspectos das traduções de Amora, seja para o espanhol, seja para o inglês. Visando a reflexões ativamente queer, este artigo busca empreender um debate sobre o significado político da tradução em nível global.
Uma tradução de “A Bird of Bagdad”, de O. Henry
Authors: Steil Juliana , Chamorro Bonow Ana Paula
Published: February 2025

Este artigo apresenta uma tradução do conto “A Bird of Bagdad” (1910), de O. Henry, para o português brasileiro. O. Henry tornou-se popular ao escrever sobre pessoas comuns, e ambientou muitos de seus contos na cidade de Nova York. “A Bird of Bagdad” é bastante representativo tanto do estilo de O. Henry quanto de sua temática nova-iorquina. Publicado originalmente na coletânea Strictly Business: More Stories of the Four Million (1910), o conto em questão traz a história do proprietário de um pequeno restaurante que sai à noite em busca de emoção — de desconhecidos com casos interessantes para contar e aos quais possa oferecer ajuda. Em uma de suas caminhadas, encontra um jovem que precisa solucionar um enigma. A presente tradução preocupa-se com refazer as particularidades das falas das personagens em diálogo, que cumprem um papel importante no efeito humorístico do conto, e o jogo de palavras que compõe o enigma, elemento crucial no desenvolvimento do enredo.
Resenha de Translation: the basics de Juliane House
Authors: Ferreira de Souza Brito Talita
Published: February 2025

A obra Translation: the basics de Juliane House é uma introdução acessível aos Estudos de Tradução, abrangendo questões essenciais nessa área. Dividido em quatro partes, o livro explora tópicos como a natureza da tradução, as competências necessárias aos tradutores, a influência da cultura e da ideologia na tradução e a evolução histórica da prática. A segunda parte aborda conceitos teóricos, como traduzibilidade, equivalência e critérios de qualidade. A autora apresenta seu próprio modelo de avaliação e discute o uso de corpora na pesquisa de tradução. Na terceira parte, House explora novas tendências nos estudos de tradução, como a compreensão do processo mental dos tradutores e o impacto da tecnologia digital e da globalização. A última parte concentra-se nos papéis da tradução em contextos do mundo real, incluindo situações profissionais e educacionais. A autora discute questões éticas e o crescente envolvimento de pessoas comuns em atividades de tradução.
Towards the discovery of molecules with anti-COVID-19 activity: Relationships between screening and docking results
Authors: Anokhin Dmytro , Kovalenko Sergiy , Trostianko Pavlo , Kyrychenko Alexander , Zakharov Anton , Zubatiuk Tetiana , Ivanov Volodymyr , Kalugin Oleg
Published: February 2025

The study presents the results of a combined approach to the theoretical description of potential antiviral activity against COVID-19. We found that pharmacophore screening based on limited experimental data on "protein-ligand" binding complexes might have low predictive ability. Therefore, in this study, we build a model based on the statistical description of QSAR for data obtained from docking which serves as a basis for adequate prediction of ligand activity. We use the logistic regression to construct the predictive model for the main protease Mpro inhibitors.
Antiviral nutraceuticals from pomegranate (Punica granatum) juice
Authors: Rehan Haider , Geetha Kumari Das , Zameer Ahmed Khanzada , Sambreen Zameer Khanzada
Published: February 2025

Pomegranate (Punica granatum) boasts a rich history of medicinal use and is prized for its exceptional phytochemical composition. Abundant in bioactive compounds such as polyphenols, flavonoids, and tannins, pomegranate exhibits significant antiviral properties, acting through various mechanisms, including impeding viral attachment and entry, suppressing replication, and enhancing the immune response. This study has explored the antiviral efficacy of pomegranate juice extracts against a spectrum of viruses, including common pathogens. Findings suggest that the blend of blue and red colors in these extracts can inhibit viral replication and reduce viral load, making them promising candidates for antiviral therapeutics. Moreover, the high antioxidant content of these colors contributes to mitigating oxidative stress associated with viral infections. Furthermore, the immunomodulatory effects of the blue and red color blend enhance the body's natural defense against viruses by stimulating the release of cytokines and chemokines crucial for immune responses. This combination of antiviral and immune-boosting properties positions pomegranate juice as a promising natural antiviral agent. The safety and accessibility of pomegranate juice make it an attractive option for nutraceutical development, as it is widely consumed and easily incorporated into daily dietary practices. However, further research, including clinical trials, is needed to validate its efficacy and safety in the prevention and treatment of viral infections. Utilizing standardized pomegranate-based nutraceuticals or supplements presents a novel strategy for combating various viral ailments, offering a viable alternative to conventional antiviral therapies.
Investigating the effect of autoclave steam sterilization on anodized implants for color fed issue
Authors: Rakesh Kumar , Mohit Kumar
Published: February 2025

This study aimed to investigate the effect of steam sterilization treatments on anodized titanium devices (nails) of the same length and geometry. A fixed sterilization process was employed with the parameters: temperature of 121 °C, pressure of 15 psi, and autoclaving time of 30 minutes. The objective was to examine the color-fading issue after three autoclave cycles. During sterilization, two nail samples were wrapped in sterile cloth, while the other two samples were wrapped in aluminum foil. In each cycle, a total of four samples were used. Finally, all samples were visually analyzed for any signs of color fading. This study highlighted the adverse interaction between aluminum foil and steam, leading to potential moisture retention, chemical reactions, and surface damage. Conversely, sterile cloth allowed effective sterilization while preserving the anodized coating. These findings underscore the necessity of material-specific sterilization protocols to prevent damage to anodized implants, with sterile cloth recommended to maintain both sterilization efficacy and implant aesthetics. Further research into the long-term effects of high pressure and high- temperature sterilization on anodized surfaces is suggested.
Enhanced intrusion detection framework: Integrating SMOTE-ENN with random forest and XGBoost
Authors: Sameer Tembhurney , Rashmi Jain , Khushi Barole , Khushi Malik , Rahul Raut , Prachi Joshi
Published: February 2025

The growing sophistication of cyber-attacks necessitates advanced intrusion detection systems (IDS) capable of identifying both existing and emerging threats with high precision. This study proposes an innovative IDS framework that addresses class imbalance using SMOTE-ENN (Synthetic Minority Over-sampling Technique-Edited Nearest Neighbors), while leveraging the complementary strengths of Random Forest (RF) and XGBoost classifiers to enhance detection efficacy. Evaluated on the NSL-KDD dataset, the framework effectively mitigates the challenges posed by imbalanced data, ensuring improved detection of minority attack classes. Experimental analysis demonstrates significant improvements in accuracy, precision, recall, and F1-score compared to conventional methods. These findings highlight the framework's potential to strengthen cyber intrusion detection and enhance overall network defense mechanisms.
Виклики та можливості інтеграції України в систему кібербезпеки ЄС
Authors: Савчук Сергій Олександрович
Published: February 2025

У статті висвітлено ключові аспекти розвитку системи кіберзахисту в Європейському Союзі та його значення для стійкості електронної комерції та комунальних структур. Розглянуто директиви NIS і NIS2, які встановлюють стандарти щодо норм кібербезпеки, а також Закон про кібербезпеку, який визначає процеси сертифікації ІТ-товарів і послуг. Визначено функції спеціалізованих європейських органів, таких як ENISA, CERT-EU та EU-CyCLONE, щодо організації реагування на протидію кіберзагрозам, методам посилення міжнародної співпраці та обміну розвідданими. В статті представлено скориговану структуру механізму цифрового захисту національної держави, яка об’єднала принципи, характерні для європейського режиму утвердження цифрових гарантій. Запропонована модель передбачає унікальні обов’язки органів державного управління, які розроблені відповідно до запропонованої в статті стратегії та сприяють як найму експертів, так і державно-приватній співпраці. Результатом втілення моделі є зміцнення критичної інфраструктури, підвищення рівня реагування на надзвичайні ситуації та надання національного характеру. В статті наголошується на важливості європейської інтеграції України в контексті зміцненні захисту від сучасних кібернебезпек і збереженні довіри в кіберсередовищі. Отримані висновки та поради можуть слугувати основою для продовження вивчення та практичного розгортання структури кібербезпеки, яка б узгоджувалася з національними та міжнародними протоколами.
Genome-Based Characterization of Bacterial Pathogens Causing Bloodstream Infection
Authors:   ,   Lebanese American University -- Chouran Beirut, Boujanian Carni
Published: February 2025

Bloodstream infections (BSIs) caused by multi-drug resistant (MDR) bacterial pathogens are considered among the risk factors that pose a severe threat to public health, leading to increased morbidity and mortality. Our understanding of BSIs has changed with the emergence of next-generation platforms and their applications in epidemiological monitoring and resistance detection. The global rise in extended-spectrum β-lactamase producing (ESBL) and carbapenem-resistant Enterobacteriaceae (CRE) worldwide is alarming. This study aimed to assess antimicrobial resistance (AMR) and virulence determinants among 24 clinical, BSI-causing bacteria recovered from a healthcare setting in Lebanon. Whole-genome sequencing, Replicon Typing, and the Kirby-Bauer disk diffusion test were used for in-depth resistance and virulence characterization. All the isolates were resistant to amoxicillin, 83% to cefotaxime, 46% to cefoxitin, 29% to imipenem, 25% to meropenem, and 12.5% to colistin. Carbapenem resistance and ESBLs were linked to several factors, including variants of NDM such as blaNDM-5 (3/24) and blaNDM-1 (3/24), variants of OXA including blaOXA-1 (9/24) and blaOXA-48 (2/24), and different β-lactamases such as blaCTX-M-15 and blaSHV-11. IncFIA, IncFIB, IncFII, IncA/C, IncX1, and IncU were among the detected replicons. This study highlights the critical public health threat posed by MDR pathogens in bloodstream infections, emphasizing the urgent need for effective and comprehensive infection control measures. The findings highlight the significance of continuous genomic surveillance and epidemiological monitoring to better understand the mechanisms driving antimicrobial resistance and to develop targeted strategies for managing MDR infections.
Innovation of Artistic Gymnastics Equipment in Limited Space
Authors: Tubagus Herlambang  , Donny Anhar Fahmi  , Utvi Hinda Zhannisa
Published: February 2025

This study was motivated by the limited space for men's artistic gymnastics in Central Java, which generally uses a small and unrepresentative school arena, so the arrangement of equipment such as uneven bars, parallel bars, rings and saddle horses is not optimal. The aim of this study is to develop innovative multifunctional artistic gymnastics equipment in a limited space to optimise the gross motor development of junior male artistic gymnasts and to improve the effectiveness and efficiency of training. The research method uses a research and development approach with quantitative data from expert questionnaires, athletes and coaches, as well as analysis of equipment innovation based on Computer Aided Design (CAD) technology. The results of the analysis showed the maximum stress on the developed equipment, namely single bars 45.7 MPa, parallel bars 72.6 MPa, straps 29.48 MPa and saddles 92.9 MPa, which are located at the ends near the pivot point. The results of the analysis showed that the Innovation products are safe to use. The conclusion the conclusion of this research is the creation of artistic gymnastics equipment innovation in a limited space that is feasible to use.
De Instituto Literario de San Juan a Instituto Juan José de la Garza (1858-1913). Una institución educativa para jóvenes de la época de la Reforma y del Porfiriato en Tamaulipas.
Authors: Flores Mendez Yessenia
Published: February 2025

Este artículo trata del origen e historia del Instituto Literario de San Juan (ILSJ) de Matamoros, Tamaulipas, fundado en 1858, que representa una de las primeras instituciones que ofreció educación secundaria-preparatoria y profesional para los jóvenes tamaulipecos.  El ILSJ fue creado en la segunda etapa de creación de los institutos literarios en México, que corresponde a la época de la reforma liberal. La institución pasó por dos etapas en su origen, desarrollo y final, la primera de su fundación en 1858 a 1897, que impartió los estudios preparatorios y la formación de abogados, que reabrió en 1889 y la ingeniería; en una segunda etapa en el porfiriato de 1898 a 1910, cuando fue reorganizado y renombrado Instituto Juan José de la Garza, e impartió los estudios de preparatoria, Normal, y carreras técnicas. En 1913 tras la revolución mexicana fue cerrado pero ya estaba en decadencia. En la posrevolución solo tuvo continuidad como escuela secundaria y preparatoria. La investigación está fundamentada con documentos del Archivo Histórico del Estado de Tamaulipas, y Archivo del Congreso del Estado, decretos, reglamentos y periódico oficial
Comulgar con ruedas de molino La sociedad tamaulipeca a finales del siglo XIX en un artículo de Juan B. Tijerina
Authors: Certucha Mercedes
Published: February 2025

A partir del análisis de un artículo publicado en 1900 en el periódico tamaulipeco El Progresista, en este artículo se ponderan los cambios y transformaciones que se percibían en la sociedad victorense al finalizar el siglo XIX. Datos de la biografía intelectual de su autor, el intelectual, maestro, escritor y poeta Juan B. Tijerina enmarcan la visión de este autor sobre la función social de la mujer en un momento de transición. Tijerina atisba un cambio en el comportamiento femenino y en la apreciación social de las mujeres al dejar atrás un plano de subordinación en el que cumplen un papel de proselitismo religioso asignado sutil y convenientemente por el clero católico. Tijerina parte de la afirmación del influyente obispo de San Luis Potosí, Ignacio Montes de Oca, quien en retadora declaración reafirma el poder de la Iglesia Católica por encima de la secularización liberal. El artículo presenta algunos de los elementos de la tensión ideológica que se percibía en el ambiente tamaulipeco al finalizar el siglo XIX
The Influence of Individual Characteristics, Training and Career Development on Employee Performance PT Hotel KTM Resort
Authors: Maisyarah  , Saputra Asron
Published: February 2025

This study analyzes the influence of individual characteristics, Training, and career development on employee performance at PT Hotel KTM Resort in Batam, Indonesia. Despite the significant role of human resources in the hospitality industry, challenges such as low employee focus and delayed career progression hinder performance. Using quantitative methods, the research examined data from 115 employees to evaluate the effects of these variables. The findings indicate that training and career development significantly impact employee performance, while individual characteristics do not considerably influence performance outcomes. Training programs tailored to employee needs and structured career development pathways enhanced job satisfaction, motivation, and overall productivity. Furthermore, simultaneous analysis revealed that these variables collectively explain 37.7% of performance variation, suggesting other influencing factors. Recommendations include improving training quality, creating clear career advancement opportunities, and adopting holistic HR management practices focusing on supportive leadership and work environments. By implementing these strategies, PT Hotel KTM Resort can enhance employee engagement, reduce turnover rates, and improve service quality. These insights contribute to the hospitality sector's broader understanding of human resource management, emphasizing the importance of investment in employee development initiatives.
Contribution to Sustainable Development Goals (SDGs):SDG 3: Good Health and Well-beingSDG 4: Quality EducationSDG 8: Decent Work and Economic GrowthSDG 9: Industry, Innovation, and Infrastructure
Identifikasi Jenis Ikan Kerapu dan Kakap Hasil Tangkapan Nelayan di Wilayah Perairan Provinsi Nusa Tenggara Barat
Authors: Santika Lora , Anas Azwar
Published: February 2025

The West Nusa Tenggara Province (NTB) serves as a pilot location for the management of grouper and snapper fisheries, setting an example for other regions in Indonesia. The enactment of Regional Regulation (PERGUB) NTB No. 55 of 2023 has become a guide and reference for the Regional Government and other stakeholders in promoting sustainable management of grouper and snapper fisheries in the NTB Province. Economically, the production of grouper and snapper fisheries in the NTB Province ranks third and is one of the top ten contributors to national grouper and snapper fisheries production (KKP, 2013). Ecologically, grouper and snapper species play a crucial role as predators, balancing the composition of fish at lower trophic levels. This research aims to determine the composition of grouper and snapper species caught in the waters of the NTB Province. Data collection was carried out through monitoring the landing of catches at fish landing centers, spanning from the year 2016 to 2022. Based on the monitoring data, 68 species of grouper and 50 species of snapper were identified. Grouper species from the Epinephelidae family, including Epinephelus coioides, Plectropomus leopardus, Plectropomus maculatus, and Variola albimarginata, dominated the catches. Meanwhile, snapper species from the Lutjanidae family, such as Lutjanus malabaricus, Lutjanus argentimaculatus, Lutjanus gibbus, and Pristipomoides multidens, were prevalent. Eight types of fishing gear were identified for catching grouper and snapper, including bottom longlines, trolling lines, harpoons, handlines, drop lines, boat traps, fixed gillnets, and fish traps.
Inovasi Kepemimpinan Kepala Sekolah dalam Mengatasi Tantangan Pendidikan di SDN 8 Buwun Mas: Studi Kasus di Daerah Kabupaten Lombok Barat
Authors: Dewi Mega Purnami , Riani S Ni Wayan Lila , Mustari Mohamad
Published: February 2025

Penelitian ini bertujuan untuk menggambarkan tantangan dan inovasi yang dihadapi oleh SDN 8 Buwun Mas, sebuah sekolah di daerah pesisir pantai bagian selatan Kabupaten Lombok Barat, serta peran kepala sekolah dalam mengatasi keterbatasan yang ada. Menggunakan pendekatan deskriptif kualitatif, data dikumpulkan melalui wawancara mendalam dengan kepala sekolah dan guru, serta observasi lapangan terhadap kondisi sarana dan prasarana. Hasil penelitian menunjukkan bahwa SDN 8 Buwun Mas menghadapi berbagai tantangan, termasuk keterbatasan infrastruktur dan aksesibilitas, serta jumlah siswa yang sedikit, sehingga berdampak pada mutu pendidikan. Kepala sekolah memainkan peran strategis dengan menerapkan kebijakan inovatif dan mencari dukungan eksternal untuk meningkatkan kondisi sekolah. Temuan ini menekankan pentingnya kepemimpinan adaptif dalam konteks pendidikan di daerah yang sangat jauh dari perkotaan, serta perlunya dukungan lebih lanjut dari pemerintah untuk memastikan pemerataan akses dan kualitas pendidikan. Penelitian ini diharapkan dapat memberikan wawasan yang berharga bagi pemangku kebijakan dan praktisi pendidikan dalam mengatasi masalah serupa di wilayah lain.
Pesquisa e Experiência do Usuário
Authors: Netto Jesse Ferreira Guimaraes
Published: February 2025

Apresenta estratégias eficazes que integram métodos inovadores de pesquisa. São exploradas as abordagens centradas no usuário, que tem sido um ponto-chave para que as empresas compreendam as necessidades e as expectativas do seu público alvo
Harnessing the synergy of generative AI, machine learning, and chatbots: Innovations in conversational systems and intelligent automation
Authors: Manjeet Malaga
Published: February 2025

The evolution in today's socio-technological world has placed generative artificial intelligence (AI), machine learning, and chatbots at the epicenter of conversational systems and intelligent automation developments. However, this research focuses on how these technologies can be fused to form synergistic cellular technologies that can revolutionize many industries. AI-powered chatbots can enrich and optimize user experience using generative AI preparatory methods. ML algorithms enhance and enrich these systems since they can make them more personalized and predictable to meet user interaction goals and automate processes. The exploratory research relies on case investigations and expert interviews to identify real-life cases and effects. Some of the findings are concerned with the following: They help to advance operation efficiency and shift the customer experience paradigm. This integration has many implications for intelligent automation and points to the future of conversational systems, which can run mostly by itself with little human interaction. With this research study, the roles and interactions of these technologies in fostering innovation and efficiency are made clear, making the survey resourceful to practice and research.
Assessment of the Impact of Mesh Density on Early and Long-term Results After Laparoscopic Transabdominal Preperitoneal Inguinal Hernia Repair
Authors: Savoliuk Serhii , Zavertylenko Dmytro , Kruhliak Yevhenii
Published: February 2025

Inguinal hernia is a common pathology. The main treatment method is surgical. Laparoscopic transabdominal preperitoneal hernia repair is a leading technique. Polypropylene mesh implants are classified by weight into heavy, medium, light, and ultralight. However, the optimal weight of the mesh to minimize complications remains debated.
The aim of the study: to determine the optimal mesh density to minimize complications after laparoscopic transabdominal preperitoneal hernioplasty.
Materials and methods. Retrospective analysis of postoperative results obtained during treatment of 178 patients with inguinal hernia hernioplasty at the Department of Surgery and Vascular Surgery of Shupyk National Healthcare University of Ukraine, Kyiv in the period from 2018 to 2022.
Results. The average duration of surgical intervention was: Group I – 87.92±14.56 min, Group II – 85.21±14.74 min, Group III – 88.9±13.92 min. The level of pain according VAS scale was: Group I – 3.04±1.05 points; Group II – 3.07±1.23 points; Group III – 3.42±1.31 points. Readiness for discharge was: Group I – 8.41±0.82 points, Group II – 8.49±0.87 points, Group III – 7.56±1.01 points. The duration of taking NSAIDs in the early postoperative period was: Group I – 2.98±1.11 days; Group II – 3.3±1.06 days, Group III – 5.03±2.25 days. The development of chronic groin pain was noted: Group II – 2 patients; Group III – 5 patients. Recurrence of inguinal hernia was noted: Group I – 3 patients; Group II – 1 patient.
Conclusions. In the scope of our research, light polypropylene mesh demonstrates itself as a optimal mesh density when performing laparoscopic TAPP, which allows to achieve a low level of development of postoperative chronic groin pain and hernia recurrencse.
“Blue Monkeys” and Space Whales.
Authors: Mirón-Florido Natalia
Published: February 2025

In Primate Visions (1898) Donna Haraway postulated the existence of aSimian Orientalism: just like Orientalism pictures Eastern communities asthe civilisational ancestors of the Western world, primatology regardsprimates as living specimens of human genetic and cultural ancestors(Said 232-234; Haraway 10-11). However, this paper aims to prove that therecan be further links between Orientalism and speciesism, using as a casestudy James Cameron’s Avatar franchise.The purpose of the first instalment is to remark on the holistic naturePandora as a planet where the homogenous Natives, the fauna and floare part of the same religious entity, Eywa. Yet the narrative placesecological values over anti-speciesist ones, by normalising the Na’vi’sdomination of non-Na’vi animals, thus hierarchising the fauna of Pandora.The second instalment attempts to compound this mistake byemphasizing egalitarian bonds with non-Na’vi animals, namely with thewhale-like tulkuns. Despite them possessing complex societies andidentities, the narrative presents them as willing victims and ostracizesindividuals who fight humans. In this way, the non-Na’vi animalsPandora are denied any agency for resistance.These failures expose that Orientalism and speciesism biases areinextricably linked: for the Western onlooker, the classification of a subjeas Oriental/Eastern transforms them into a primitive being that is closer toanimality than humanity, but closer to humanity than other non-humananimals. In short, Orientalism implies the creation of a speciesist hierarchyby which the Oriental subject is placed under white humans but overnon-human animals.
Exploring the Ethics of Animal Experimentation in Marvel’s Guardians of the Galaxy Vol. 3 (2023)
Authors: Duarte Sofia
Published: February 2025

Every so often a film is released which compels viewers to question trelationship they have with nonhuman animals and the objectificatithat society makes of them. A recent motion picture that has attemptedto rekindle the discussion regarding animal experimentation is JamesGunn’s Guardians of the Galaxy Vol. 3 (2023). Part of the Marvel CinematicUniverse, the film tells the story of a group of outcast heroes known as tGuardians of the Galaxy as they try to save the universe. This third volumefocuses on the character of Rocket, a genetically modified raccoon. Tfilm exhibits a candid depiction of the cruelty that nonhuman animaendure when exploited in vivisection and criticises the anthropocentrismthat underlies the act of experimenting on nonhuman animals throughRocket’s past. Thus, the aim of this paper is to analyse the portrayal ofRocket and the consequences of having been tested on. I argue that thefilm proposes an abolitionist stance towards the question of animtesting, hence counteracting the more widespread utilitarian perspective.Moreover, I explore how the notion of sentience plays a fundamental rolein the portrayal of the other than human beings that appear in thenarrative. In relation to this, the analysis will make use of the concept ofspeciesism to study how characters from different species interact witheach other and who is portrayed as an individual sentient being deemedworthy of being saved.
Primer conjunto de imágenes de ciudades de la Provincia Jesuítica de Quito (1718)
Authors: Schávelzon Daniel
Published: February 2025

En el año 1718 se imprimió en Quito una lámina -llamadas folio-, en que se anunciaba la presentación de una tesis en la Universidad Gregoriana. Si bien el tema era teológico, el dibujo con que era difundido el evento llevaba alusiones significativas a la tarea geográfica de los jesuitas en la región: el rey les otorgaba un plano, el primer mapa del Amazonas que había sido publicado poco antes, y once imágenes de ciudades de la Provincia Jesuítica de Quito. Si bien esquemáticas por su tamaño, son en su mayoría las primeras imágenes que existen de dichas ciudades presentadas en una especie de álbum regional. Dado que las láminas originales que sobrevivieron no pueden ser encontradas, el hallazgo de un relevamiento fotográfico hecho en la década de 1940 resulta de interés para repensar su significado, a la vez que difundir estas vistas. El conocimiento del territorio y su apropiación mediante la gráfica puede entenderse en el contexto urbano de construcción de la identidad mestiza afirmada en la religión.