bluuebunny/crossref_metadata_2025 huggingface dataset:
Bio-based polyurethane aqueous dispersions
Authors: Zhou Xing , Zhang Xin , Mengyuan Pu , He Xinyu , Zhang Chaoqun
Published: April 2021

With the advances of green chemistry and nanoscience, the synthesis of green, homogenous bio-based waterborne polyurethane (WPU) dispersions with high performance have gained great attention. The presented chapter deals with the recent synthesis of waterborne polyurethane with the biomass, especially the vegetable oils including castor oil, soybean oil, sunflower oil, linseed oil, jatropha oil, and palm oil, etc. Meanwhile, the other biomasses, such as cellulose, starch, lignin, chitosan, etc., have also been illustrated with the significant application in preparing polyurethane dispersions. The idea was to highlight the main vegetable oil-based polyols, and the isocyanate, diols as chain extenders, which have supplied a class of raw materials in WPU. The conversion of biomasses into active chemical agents, which can be used in synthesis of WPU, has been discussed in detail. The main mechanisms and methods are also presented. It is suggested that the epoxide ring opening method is still the main route to transform vegetable oils to polyols. Furthermore, the nonisocyanate WPU may be one of the main trends for development of WPU using biomasses, especially the abundant vegetable oils.
Biodegradable shape-memory polymers and composites
Authors: Alauzen Tanner , Ross Shaelyn , Madbouly Samy
Published: April 2021

Polymers have recently been making media headlines in various negative ways. To combat the negative view of those with no polymer experience, sustainable and biodegradable materials are constantly being researched. Shape-memory polymers, also known as SMPs, are a type of polymer material that is being extensively researched in the polymer industry. These SMPs can exhibit a change in shape because of an external stimulus. SMPs that are biodegradable or biocompatible are used extensively in medical applications. The use of biodegradable SMPs in the medical field has also led to research of the material in other applications. The following categories used to describe SMPs are discussed: net points, composition, stimulus, and shape-memory function. The addition of fillers or additives to the polymer matrix makes the SMP a polymer composite. Currently, biodegradable fillers are at the forefront of research because of the demand for sustainability. Common biodegradable fillers or fibers used in polymer composites are discussed in this chapter including Cordenka, hemp, and flax. Some other nonbiodegradable fillers commonly used in polymer composites are evaluated including clay, carbon nanotubes, bioactive glass, and Kevlar. The polymer and filler phase differences will be evaluated in this chapter. The recent advances in biodegradable shape-memory polymers and composites will provide a more positive perspective of the polymer industry and help to attain a more sustainable future.
Nanotechnology-based materials as emerging trends for dental applications
Authors: Barot Tejas , Rawtani Deepak , Kulkarni Pratik
Published: April 2021

Nanomaterials have unique and superior properties such as high surface area and nanoscale size, makes them highly advanced and vital for rapid diagnosis and beneficial in treatment of numerous diseases in health sector. Joint efforts from multiple disciplines have contributed to the developments of advanced nanomaterials and enabled their uses in dentistry. These advanced nanomaterials can give more promising results in diagnosis and treatment procedures compared to their conventional counterparts. This review outlines the nanomaterials available and used in dentistry and will further go into discussing the shapes and compositions of various nanomaterials relevant to dentistry. Incorporating nanoparticles in dental restorative materials can be useful for preventing and/or managing dental caries. Integrating the sciences of nanomaterials and biotechnology, nanomaterials could potentially be revolutionary in improving oral health by providing preventative and diagnostic measures; they could also have effects on repairing damaged dental tissue.
Mechanical model and contact properties of double row slewing ball bearing for wind turbine
Authors: Zhang Hongwei , Chen Shuguang , Dou Yantao , Fan Hengming , Wang Yanqin
Published: April 2021

In this paper, the mechanical models of large-scale double row slewing ball bearing considering combined loading conditions were presented based on the rigid rings and flexible rings, respectively. And the contact properties between the ball and raceway were studied. These workflows for the calculation were described and programmed by MATLAB. The load distributions of slewing bearing for 2MW wind turbine were presented. The results indicated that the load distribution with the ideal stiff assumption differs from the load distribution determined by taking into account the flexibility of rings. With flexible rings, the magnitude of contact force is less than that of the rigid rings. The influences of the initial contact angle, the coefficient of groove curvature radius, the clearance on maximum contact force were analyzed and some suggestions have been discussed. These parameters have significant effects on the load distribution. The maximum contact force decreases with coefficient of groove curvature radius decrease. A three dimensional finite element model of the slewing bearing is established and analyzed. The simulated results are compared with that of mechanical models.
Supramolecular solvent-based microextraction techniques for sampling and preconcentration of heavy metals: A review
Authors: Jalili Vahid , Zendehdel Rezvan , Barkhordari Abdullah
Published: April 2021

Even very low concentrations of heavy metal pollutants have adverse effects on the environment and on human health. Thus, determining even trace concentrations of heavy metals in various samples has attracted a lot of attention. The conventional analytical methods used for the sampling and analysis of heavy metals have some limitations, including the effects of the matrix and their high detection limits. Thus, various methods are used for the pretreatment and concentration of the target analytes, and these methods are time-consuming, expensive, and require the use of toxic solvents. In recent years, supramolecular solvent-based microextraction (SSME), a green analytical strategy, has been used to determine low concentrations of heavy metals in various matrices. This method has unique features such as high enrichment factor, short extraction time, and rapid analysis. In addition, it is cost effective because it consumes less chemical reagents than other methods. Also, it is ecofriendly, and it has good sensitivity and selectivity. Herein, we presented a comprehensive review of the application of the SSME technique for the analysis of heavy metals in water, food, and biological samples. Also, we have provided the distinctive properties of the SSME technique, discussed the challenges that lie ahead, and addressed the potential future trend.
SH-SY5Y-derived neurons: a human neuronal model system for investigating TAU sorting and neuronal subtype-specific TAU vulnerability
Authors: Bell Michael , Zempel Hans
Published: April 2021

The microtubule-associated protein (MAP) TAU is mainly sorted into the axon of healthy brain neurons. Somatodendritic missorting of TAU is a pathological hallmark of many neurodegenerative diseases, including Alzheimer’s disease (AD). Cause, consequence and (patho)physiological mechanisms of TAU sorting and missorting are understudied, in part also because of the lack of readily available human neuronal model systems. The human neuroblastoma cell line SH-SY5Y is widely used for studying TAU physiology and TAU-related pathology in AD and related tauopathies. SH-SY5Y cells can be differentiated into neuron-like cells (SH-SY5Y-derived neurons) using various substances. This review evaluates whether SH-SY5Y-derived neurons are a suitable model for (i) investigating intracellular TAU sorting in general, and (ii) with respect to neuron subtype-specific TAU vulnerability. (I) SH-SY5Y-derived neurons show pronounced axodendritic polarity, high levels of axonally localized TAU protein, expression of all six human brain isoforms and TAU phosphorylation similar to the human brain. As SH-SY5Y cells are highly proliferative and readily accessible for genetic engineering, stable transgene integration and leading-edge genome editing are feasible. (II) SH-SY5Y-derived neurons display features of subcortical neurons early affected in many tauopathies. This allows analyzing brain region-specific differences in TAU physiology, also in the context of differential vulnerability to TAU pathology. However, several limitations should be considered when using SH-SY5Y-derived neurons, e.g., the lack of clearly defined neuronal subtypes, or the difficulty of mimicking age-related tauopathy risk factors in vitro. In brief, this review discusses the suitability of SH-SY5Y-derived neurons for investigating TAU (mis)sorting mechanisms and neuron-specific TAU vulnerability in disease paradigms.
Texts: A Case Study of Joint Action
Authors: Gangopadhyay Nivedita , Pichler Alois
Published: April 2021

Our linguistic communication often takes the form of creating texts. In this paper, we propose that creating texts or ‘texting’ is a form of joint action. We examine the nature and evolution of this joint action. We argue that creating texts ushers in a special type of joint action, which, while lacking some central features of normal, everyday joint actions such as spatio-temporal collocation of agency and embodiment, nonetheless results in an authentic, strong, and unique type of joint action agency. This special type of agency is already present in creating texts in general and is further augmented in creating texts through digital media. We propose that such a unique type of joint action agency has a transformative effect on the experience of our sense of agency and subjectivity. We conclude with the implications of the proposal for social cognition and social agency. The paper combines research in philosophy of mind with the emerging fields of digital humanities and text technology.
The role of schemas and scripts in pictorial narration
Authors: Ranta Michael
Published: April 2021

The theoretical debate on the nature of narrative has been mainly concerned with literary narratives, whereas forms of non-literary and especially pictorial narrativity have been somewhat neglected. In this paper, however, I shall discuss narrativity specifically with regard to pictorial objects in order to clarify how pictorial storytelling may be based on the activation of mentally stored action and scene schemas. Approaches from cognitive psychology, such as the work of Schank, Roger C. & Robert P. Abelson. 1977.Scripts, plans, goals and understanding. Hillsdale, NJ: Lawrence Erlbaum; Mandler, Jean Matter. 1984.Stories, scripts, and scenes: Aspects of schema theory. London/Hillsdale, NJ: Lawrence Erlbaum; Schank, Roger C. 1995.Tell me a story: Narrative and intelligence. Evanston, IL: Northwestern University Press, suggest that cognition crucially depends on the storage and retrieval ofaction scripts or schemata, that is, narrative structures, which may occur at various levels of abstraction. These schemas incorporate generalized knowledge about event sequences, such as the order in which specific events will take place; causal, enabling, or conventionalized relations between these events, and what kind of events occur in certain action sequences. There also arescene schemasthat are characterized by spatial rather than temporal relations. Further kinds of schemas seem also to play a decisive role. Drawing upon considerations from schema and script theory, I will focus on some concrete examples of pictorial narration, more specifically depictions of theAnnunciation of the Virgin Mary, where narrative schema structures become involved and, indeed, the comprehensibility of the pictures as such presuppose mental script representations.
NMR spectroscopy threshold signal-to-noise ratio
Authors: Kolar Petar , Blažok Lovro , Bojanjac Dario
Published: April 2021

Ever since noise was spotted and proven to cause problems for the transmission and detection of information through a communication channel, a standard procedure in the process of characterizing a detection system of the communication channel is to determine the level of the lowest detectable signal. In signal processing, this is usually done by determining the so-called threshold signal-to-noise ratio (SNR). This determination is especially important for the communication channels and systems that constantly operate with low-level signals. A good example of such a system is definitely the NMR spectroscopy system. However, to the authors’ knowledge, the threshold SNR value of NMR spectroscopy systems has not been determined yet. That is why the experts in the field of NMR spectroscopy were asked to assess, using an online questionnaire, which SNR level they considered to be the NMR threshold SNR level. Afterwards, the threshold value was calculated from the obtained data. Finally, it was compared to the existing rule of thumb and thus, a conclusion about its legitimacy was made. The described questionnaire is still available online (https://forms.gle/Y9hyDZ1v1iJoEbk27). This enables everyone to form their own opinion about the threshold SNR level, which the authors encourage the readers to do.
Classification of gear pitting damage using vibration measurements
Authors: Grzeszkowski Mateusz , Nowoisky Sebastian , Scholzen Philipp , Kappmeyer Gregor , Gühmann Clemens , Brimmers Jens , Brecher Christian
Published: April 2021

In future aero engines, a planetary gearbox is to be integrated between fan and turbine to increase the efficiency and bypass ratio. This gearbox has to be monitored during operation to detect possible gearbox faults such as gear wear or gear pitting at an early stage. This paper presents a method consisting of vibration measurement, sensor-dependent feature extraction and support-vector machine (SVM)-based classification of pitting for gear condition monitoring. Several gears were loaded with a constant torque on a standardized back-to-back test rig to provoke pitting, and the pitting amount was captured during the tests with a camera. Features are extracted from accelerometers and an acoustic emission sensor, and based on the results of the visually recorded pitting surface, SVM classification is applied to identify the pitting defect. In this contribution, two different SVM classification approaches are investigated. One approach uses a Two-Class SVM, where tests from one gearset are used for SVM training and another approach utilizes a One-Class SVM based on outlier detection. Both methods show that single tooth pitting defects with a relative pitting area of less than 1 % can be effectively identified, whereas the One-Class SVM method showed a higher pitting detection accuracy.
Simple mathematical models for controlling COVID-19 transmission through social distancing and community awareness
Authors: Elgazzar Ahmed S.
Published: April 2021

The novel COVID-19 pandemic is a current, major global health threat. Up till now, there is no fully approved pharmacological treatment or a vaccine. Also, its origin is still mysterious. In this study, simple mathematical models were employed to examine the dynamics of transmission and control of COVID-19 taking into consideration social distancing and community awareness. Both situations of homogeneous and nonhomogeneous population were considered. Based on the calculations, a sufficient degree of social distancing based on its reproductive ratio is found to be effective in controlling COVID-19, even in the absence of a vaccine. With a vaccine, social distancing minimizes the sufficient vaccination rate to control the disease. Community awareness also has a great impact in eradicating the virus transmission. The model is simulated on small-world networks and the role of social distancing in controlling the infection is explained.
Determinants of citizens’ attitude to the activities of the President of Ukraine (1994–2020)
Authors: Reznik Oleksandr
Published: April 2021

The article analyzes the determinants of citizens’ assessment of the activity of the Presidents of Ukraine during 1994–2020. The institution of the Presidency in the mass consciousness of Ukrainians is a reflection of social stratification. Social groups, formed mainly by different identities, evaluate the President's activities through the prism of their own economic situation, ideological identification, ethno-cultural affiliations, ethno-political aspirations and geopolitical orientations. The attitudes of Ukrainians to the head of state are related to electoral cycles, when the most positive assessments of activity are observed in the first year after the election. Using the method of multiple linear regression, it was found that the socio-economic determinant of the financial situation of the family was less tied to the electoral cycles: regardless of the term of office of the President , wealthy citizens evaluate his activities more positively while the poor ones evaluate it more negatively. In the mid-1990s, the attitudes towards the President of Ukraine were also differentiated by a region of residence and a language of communication in the family. However, after 2004 the factor of language communication in the family has reduced its influence on the assessment of the President's actions in favor of the question of the expediency of the Russian language official status. The factor of regional polarization restored its influence during 2003–2013. At the same time, since the end of the 1990s, the factor of geopolitical orientations of citizens has been gaining influence and has become one of the key ones in the following years. The assessment of the activities of Viktor Yushchenko, Viktor Yanukovych and Petro Poroshenko is characterized by clear geopolitical orientations. Instead, the attitudes to the activities of President Volodymyr Zelenskyi in the second year of his term are characterized by a negative attitude of respondents with both left and right ideological views.
Labor in the 21st century: challenges of post-Fordism / neoliberalism and the situation of working people in the modern global world
Authors: Butkaliuk Vitalina
Published: April 2021

The article examines the current problems of the global sphere of work and employment. The author historically assesses the causes and consequences of the structural transformations of the economy and social and labor relations as a result of the transition of the capitalist economy from fordism and keynesianism to post-fordism and neoliberalism at the end of the 20th century. Based on the analysis of a significant array of statistical and sociological information the author concludes that in the conditions of neoliberal economic globalization, labor has undergone significant changes in comparison with the period of the "glorious post-war thirty years" of capitalism. The implementation of radical economic reforms has led to an increase in employment vulnerability and a decrease in the quality of working life for many categories of workers in the modern world. The decline in the share of labor in GDP, the lag in wage growth rates from labor productivity, and the widespread incidence of informal and vulnerable employment, characteristic of this period, have become the main reasons for the growth of socioeconomic inequality and widespread poverty and poverty in the working environment in recent decades. Having considered the impact of the current process of automation, robotization and digitalization of the global economy, the author concludes that without changing the socio-economic and political configuration of the structure of the modern world, the potentially high utility of the latest achievements of science and technology will be significantly limited and subordinated mainly to the economic interests of capital owners, and will not work for the benefit of all humanity and social progress. The article pays special attention to studying the consequences of the COVID-19 pandemic in the context of their impact on the position of employees in the modern world.
Validation of reputation measurement methods in the post-Soviet territory
Authors: Sokolovskyy Ivan , Potapova Daria , Tienin Pavlo
Published: April 2021

Different approaches to definition of “reputation” concept and its presence in different disciplines’ discourse result in development of large number of reputation measurement approaches. The closest approaches to the sociological understanding of reputation are the RQ (CRQ) and RepTrak™ ones. These approaches were developed by western authors and have not been validated in the post-Soviet territory yet. The paper reviewed the verification of RepTrak™ methodology’s reliability and validity, and analyzed the terminological differences between the types of validity used by the authors of the methodology and their semantic counterparts, traditional for sociology. It is noted in the article that the developers of the methodology did not offer a unified model of corporate reputation; validation was carried out separately for two reputation constructs. The first construct confirms the connection between the emotional component of reputation and articulated willingness to act, the second — between the emotional and cognitive components of reputation. Using empirical data collected in Ukraine, Russia and Kazakhstan, the authors of the article reproduced the procedures and approaches used by the methodology developers for confirmation of the methodology’s reliability and validity. To this end, authors of the article used confirmatory factor analysis and built structural models that fully correspond to the models used by the developers of the model. The authors of the article compare the parameters of the models and their criteria of fitting to the empirical data. As a result of a comparison done for each reputational construct a conclusion about the possibility of using the emotional reputation index in all three countries was done. It was concluded also that it is possible to use a complete original methodology for reputation research in Ukraine and Russia and it is required to modify it for Kazakhstan.
Parental socioeconomic status in childhood and individual’s attitudes in adulthood
Authors: Malynovska Olha , Maltseva Kateryna
Published: April 2021

The present publication focuses on the relationship between parental socioeconomic status in individual’s childhood and his/her attitude formation in adulthood. Based on prior empirical work on the effects of early life SES on general life outcomes in adulthood, as well as data collected in a series of semistructured interviews (N = 10), for this study we have identified several objects of relationship that can be influenced by the socio-economic situation. Specifically, in the analysis of interviews we have short-listed a number of objects, attitudes towards which were shown to vary across different socioeconomic categories in childhood, e.g. money, housing, food, clothes, time, regulations, schooling, creativity, parents, future spouse, children, friends and strangers. These topics were further developed in the questionnaire to test the results that emerged from the analysis of interviews. The quantitative stage was conducted in the form of self-administered survey (N = 245). Based on the results of ANOVA and regression analysis, those individuals whose parents have had stable to relatively stable financial situation in the past showed little difference from each other, while the individuals with more modest background displayed more distinct attitudes toward time, money, regulations and clothes. Unstable financial situation in childhood in our sample also affected consumer’s behavior regarding clothes — the ‘extra’ money was invested into expensive wardrobe items. Furthermore, depending on their past financial situation, individuals in our sample varied in their attitudes toward money and time. The importance of money as such increased if individual’s financial situation became more favorable throughout the life course. Financial situation in childhood also affected one’s attitudes toward food.
Principles of assessing quality of academic publications and ranking of research and university teaching personnel
Authors: Savelyev Yuriy
Published: April 2021

The paper indicates existing limitations of approaches to the evaluation of the effectiveness of research output and current systems for ranking of scientists and university faculty members. Based on the 10 principles of the Leiden Manifesto, the author proposes essential rules of the quality assessment system of academic publications. The paper substantiates that such a system is aimed to motivate conscientious and efficient researchers within the scope of separate fields of study. Meaningful qualitative assessment avoids excessive and false precision of measurement and embraces ranking by performance categories rather than simple scores, peer review and qualitative levels of publications estimated by their contribution to the field instead of formal features. A particular emphasis is given on the need to take into account high quality leading studies published in Ukrainian and specific disciplinary formats for presenting research results as important local forms of knowledge, the size of authorship teams, as well as the duration of the research and publication cycle. The proposed approach may help to ensure the systematic and robust evaluation of research results and would facilitate the academic performance in Ukraine.
"Society after pandemic: Ukraine and the world". The 14th annual conference (International Sociological Readings) in memory of Nataliia Panina
Authors: Maksymenko Ol'ha
Published: April 2021

How much has the world around us changed for the past year? What kinds of societal shifts have occurred in some spheres such as sociological research, secondary and higher education, management, journalism, interpersonal communication or social work? What other kinds of transformation is society likely to undergo in the near future? These were the questions that both participants in and guests of the 14th annual conference in memory of Natalia Panina (1949–2006) sought to answer. The conference, also known as the International Sociological Readings, took place on 10 December 2020 and was hosted by the Institute of Sociology of the National Academy of Sciences of Ukraine. Structurally, the event consisted of two parts: a plenary session and a round-table discussion. At the plenary session, four speeches were delivered: “Survey techniques during the pandemic” (V. Paniotto), “Social inequality and extraordinary events” (S. Makeev and N. Kovalisko), “Higher education in times of and post-COVID-19” (V. Bakirov and M. Aharkov), “COVID-19: New daily routines of Ukrainian teachers, students and parents” (O. Maksymenko). The round-table discussion titled “Society and pandemic” was open to everyone interested. They could join the discussion via Google Meet. The Readings ended with the presentation of a book “Separate sociological approximations” authored by Serhii Makeev.
Timely thoughts upon the 20th anniversary of the Decree of the President of Ukraine "On the Development of Sociological Science in Ukraine"
Authors: Iakovenko Iurii
Published: April 2021

The essay presents the author's subjective perception of a number of state institutions’ activities regarding their implementation of the directives of the Decree of the President of Ukraine «On the Development of Sociological Science» dated 25.04.2001 for twenty years from the date of its publication. The author's subjective point of view, in particular, is a consequence of the fact that he was a member of the working group on the development of this decree, and the beginning of the 21st century was a time when the Ukrainian society, state, political, public figures, scientists were expecting the decisive development of various spheres of life. However, in fact, these expectations met with latent resistance from shadow structures, the essence of which was to avoid publicly disclosing their intentions through science and education. So, because of the Ministry of Education and Science order No. 642 of July 9, 2009 «On the organization of the study of humanitarian disciplines at the free choice of the student», the active part of youth, namely students was given a very narrowed way of social development understanding; primarily it have happened in technical universities, where the members of executive branch of the power will have been taught en masse. It is when the financial interests are embodied through the implementation of large-scale technical and economic projects, for example, the construction of highways, and not the protection of public health. However, in the leading universities, where sociologists have been taught, the initiative of teachers to show their will to improve the quality of the students’ preparing and evaluation does not subside.
Controversial technologies in intramedullary osteosynthesis of rats femur fractures
Authors: Mansyrov Asif , Lytovchenko Viktor , Garyachiy Yevgeniy , Lytovchenko Andriy , Miroshnichenko Olena
Published: April 2021

The aim: to conduct a comparative study of osteoreparative regeneration, namely in the periosteal and intermediate areas of the cortex, during intramedullary osteosynthesis of the femur of rats with and without reaming of the bone marrow canal.
Materials and methods. The work is based on the results of an experimental study conducted on 56 white mature laboratory rats, which simulated diaphyseal fracture of the femur and performed stable nail osteosynthesis with reaming of the bone marrow canal in the first series and without reaming in the second series of the experiment. Histological examination of the specimens was performed on the 7th, 14th, 28th and 90th day after surgery.
Results. The procedure of reaming the bone marrow canal reduces the potential reparative capacity of bone tissue in the endosteal area and leads to “distorted” activation of the process of the cortex restructuring. There is a significant activation of osteoclastic resorption.
Conclusions. Bone fusion is more active with the use of intramedullary fixator without reaming of the bone marrow canal, because its reaming reduces the manifestations of reparative potentials in the endosteal region and leads to excessive activation of the resorptive process of restructuring the cortex of both endosteal and central part
The effect of anesthesia on the risk of postoperative myocardial injury in elderly patients with hip fracture: randomized controlled trial
Authors: Kuchyn Iurii , Tokar Ihor , Bielka Kateryna , Artemenko Valerii , Semenko Nataliia
Published: April 2021

Hip fractures are a common pathology among patients older 50 years and cause disability, reduced duration and quality of life, even with adequate management and surgery. In the perioperative period, the most common complications leading to the death of patients are cardiovascular disease. about a hip fracture.

The aim of our study was to determine the safest method of anesthesia in the context of acute myocardial injury during hip fracture surgery. The objectives of the study were to determine the frequency of postoperative myocardial damage in patients with hip fractures; compare the frequency of MINS with different types of anesthesia: general anesthesia (GA), spinal anesthesia (SA) and compartment psoas block with sciatic nerve block.

Materials and methods. Randomized controlled trial was conducted from January 2018 to August 2019 in the medical center “Into-Sana” (Odessa, Ukraine). Patients with planned osteosynthesis of the proximal femur were randomized into 3 groups depending on the method of anesthesia: general anesthesia and postoperative systemic analgesia, spinal anesthesia and postoperative systemic analgesia, prolonged compartment psoas block with sciatic nerve block.

Results. The study involved 90 patients. Acute postoperative myocardial injury was diagnosed in 17.6 % of cases. Postoperative elevation of troponins was significantly more often diagnosed in groups of patients with spinal anesthesia and general anesthesia compared to the group in which the psoas block compartment was used in combination with the sciatic nerve block. None of the patients had symptoms of myocardial ischemia and were not diagnosed with myocardial infarction. Hypotension was significantly more common in group 2 spinal anesthesia (OR 9 95 % CI 1.9-47, p=0.004) There was a direct moderate association between the intraoperative hypotension and the development of postoperative myocardial injury (r = 0.5).

Conclusions. Prolonged compartment psoas block with sciatic nerve block intraoperatively is the safest method of anesthesia in the context of the development of postoperative myocardial injury. Intraoperative hypotension is associated with postoperative myocardial injury
State of social and psychological adaptation in patients with depressive disorders, taking into account the gender factor
Authors: Belov Oleksandr
Published: April 2021

The aim: to establish the features of socio-psychological adaptation in patients with depressive disorders, taking into account age and gender factor.

Materials and methods. A clinical and psycho-diagnostic examination of 107 men and 138 women with depressive disorders using the method of diagnosis of socio-psychological adaptation of C. Rogers et R. F. Dymond was done.

Results. A low level of socio-psychological adaptation in patients with depressive disorders has been established. There is a tendency to deteriorate socio-psychological adaptation with age, the most pronounced in level of adaptability, emotional comfort, payroll, integrated indicators of adaptation, self-acceptance and emotional comfort in all patients, and in men also in maladaptation, self-acceptance, external control, and women – regarding internality. The rates of lying, acceptance of others and dominance in men and women were highest in the middle age group (30-44 years), and lowest – in the older (over 45 years); this trend is also found in men for internal control and an integrated indicator of acceptance of others, and in women – for the desire for dominance. Differences in the comparison of the older age group with the average were more significant than in the comparison of the younger group (up to 30 years) with the average.

Conclusions. Patients with depressive disorders are characterized by a low level of socio-psychological adaptation. In both men and women, the level of socio-psychological adaptation decreases with age, and in men this trend is more pronounced. The most significant deterioration in the state of socio-psychological adaptation in patients with depressive disorders occurs at the age of over 45 years; this trend is also more common in men
Prospects for the use of the method of intravesical hyperthermic chemotherapy in the treatment of patients with non-muscle invasive bladder cancer
Authors: Chystiakov Roman
Published: April 2021

The aim: to compare disease-free survival time (DFS) in high-risk non-muscle-invasive bladder cancer patients treated with adjuvant hyperthermic intravesical chemotherapy and standard BCG therapy.

Materials and methods: patients were divided into 2 groups. Group 1 (control) included patients who received adjuvant therapy after TURB with BCG vaccine (BCG therapy group; n=50), group 2 (study group) included patients (HIVEC® therapy group; n=46 ), who received adjuvant intravesical chemotherapy using a Combat BRS HIVEC® device for local hyperthermia.

Results: median follow-up was 23 months (range 4 - 36). Tumor recurrence was reported in 19 patients receiving intravesical BCG therapy and in 8 patients receiving intravesical hyperthermic chemotherapy. The incidence of DFS in patients receiving chemohyperthermy was statistically higher than in patients receiving BCG therapy (log-rank test result: p=0.029).

Conclusions: The method of hyperthermic intravesical chemotherapy significantly increased the 2-year disease-free survival rate - 82.6 % versus 62 % BCG therapy group (p=0.025). Its use in the future will allow increasing the frequency of organ-preserving treatment of patients with primary and recurrent muscular-non-invasive bladder tumors
Myelin basic protein and its diagnostic value in HIV-infected individuals with 4th clinical stage and neuroinfections
Authors: Kozko Volodymyr , Hvozdetska-Shaar Maryna , Sokhan Anton , Yurko Kateryna , Solomennyk Ganna
Published: April 2021

It was shown that in HIV-infected patients, pathomorphological changes in the white matter in the form of demyelinization are already observed in the early stages of the disease. The most studied marker of this process is myelin basic protein that can be detected in cerebrospinal fluid or serum immediately after acute myelin breakdown.

The aim. To assess the diagnostic value of myelin basic protein content in serum and cerebrospinal fluid of HIV-infected individuals with 4th clinical stage and central nervous system opportunistic infections.

Materials and methods. Using ELISA with diagnostic kit “MBP ELISA” (Ansh Labs, USA), we studied the myelin basic protein content in serum and cerebrospinal fluid of 53 HIV-infected patients with 4th clinical stage and central nervous system opportunistic infections depending on its etiology, the outcome of the diseases and according to Glasgow coma scale score. As well correlation analysis with some laboratory and clinical indicators was performed.

Results. We found significantly increased myelin basic protein content in both cerebrospinal fluid and serum of HIV-infected patients 4th clinical stage with central nervous system opportunistic infections compared to control (p˂0.01), which indicate the presence of active demyelinization in central nervous system. The highest cerebrospinal fluid myelin basic protein was registered in patients with an unfavourable outcome of the disease, as death or residual neurologic deficit, and patients with cerebral toxoplasmosis. The cerebrospinal fluid myelin basic protein had an association with the size of white matter lesions on magnetic resonance imaging and serum myelin basic protein content.

Conclusions. Myelin basic protein detection in cerebrospinal fluid as well as in serum can serve as an additional quantitative marker of myelin disruption, which can be used along with magnetic resonance imaging for the diagnosis improvement and prognosis of central nervous system opportunistic infections in HIV-infected individuals with 4th clinical stage
Predictors of genitourinary syndrome in women of elderly reproductive age after hysterectomy
Authors: Proshchenko Olha , Ventskivska Iryna , Kamuz Natalia , Markitanyuk Svitlana
Published: April 2021

The article presents an analytical assessment of risk factors for distant postoperative urogenital disorders in women of older reproductive age after radical surgical treatment for uterine fibroids.
The aim of the study was to optimize the diagnostic algorithm of genitourinary syndrome in women of older reproductive age after hysterectomy for uterine fibroids.
Materials and methods – 80 women aged 40 to 50 years were examined: 40 patients after vaginal and laparoscopically assisted vaginal hysterectomy, 40 patients with abdominal hysterectomy, control – 30 relatively healthy women with asymptomatic fibroids. The examination was performed at the stage of preoperative observation and for 3 years after surgery. Research methods: data on the assessment of pelvic floor and urogenital dysfunction using a standardized POP-Q system, physical examination, the ICS classification was used to assess the severity of urinary incontinence; quality of life assessment using the MOS SF-36 questionnaire; standard methods of variation statistics.
Research results and their discussion. The most important risk factors for genitourinary syndrome have been identified. These included obstetric and gynecological history (birth of large fetuses, episiotomies, birth trauma, high birth parity, ovarian surgery, the use of gonadotropin-releasing hormone agonists), chronic diseases accompanied by increased intramuscularly; the presence of stigmas of undifferentiated connective tissue dysplasia; clinical manifestations of pelvic floor failure and functional disorders of the urethral sphincter.
Conclusions. In the case of surgical treatment of uterine fibroids, it is advisable to take into account not only the presence of vaginal prolapse and initial dysuric manifestations, but also their predictors in the preoperative stage of the examination, as this may affect the choice of method and access in the case of surgical treatment of uterine fibroids. rehabilitation program and will obtain the expected effect of surgical recovery.
Influence of different types of anesthesia on the inflammatory response in laparoscopic hysterectomy
Authors: Zaychenko Stanislav , Tkachenko Ruslan
Published: April 2021

The aim of the study was to evaluate the influence of different variants of anesthesia, including low-opioid (LOA) and opioid-free anesthesia (OFA), on the dynamics of the inflammatory response during laparoscopic hysterectomy.

Materials and methods: 102 patients were randomly allocated into 3 groups: 37 women assigned to receive a standard opioid-based anesthesia (OBA group), 33 women – LOA group and 32 patients – OFA group. In the LOA group, the amount of fentanyl was halved and lidocaine infusion and ketamine were additionally infused during induction. In the OFA group, ketamine, lidocaine and dexmedetomidine were additionally infused instead of fentanyl.

Results: Conducting a laparoscopic hysterectomy is accompanied by the activation of the inflammatory process and is manifested by an increase in the content of leukocytes and granulocytes, and a decrease in the number of lymphocytes, which is accompanied by an increase in the leukocyte index of intoxication. These changes were most significant in patients undergoing standard anesthesia. The activation of the inflammatory process is confirmed by an increase in the level of pro-inflammatory IL-6 in all groups from 28.8 % to 92.9 %, and it was most pronounced in patients who underwent LOA. In the same group, the greatest increase in the level of anti-inflammatory IL-10 was also noted, the level of which was 115.4 % higher (p=0.036) than in the control group. An increase in the content of the pro-inflammatory cytokine IL-6 in each group and a parallel increase in anti-inflammatory IL-10 in groups 2 and 3, with a simultaneous decrease in it in group 1 led to a significant increase in the IL-6 / IL-10 ratio in the control group. This indicator was significantly higher than in groups 2 and 3 by 42.3 % (p=0.043) and 52.7 % (p=0.041), respectively, while the IL-6 / IL-10 ratio in these groups was not differed from the initial state.

Conclusion: Laparoscopic hysterectomy is accompanied by activation of the inflammatory process and is manifested by an increase in the content of leukocytes and granulocytes and a decrease in the number of lymphocytes, which is accompanied by an increase in the leukocyte index of intoxication. These changes were most significant in patients undergoing standard anesthesia. The use of LOA and OFA is accompanied by a lower activation of the inflammatory response in laparoscopic hysterectomy than in standard anesthesia, but requires further study
The problem of choosing anesthesia method for surgical interventions on the lower limbs in young patients
Authors: Georgiyants Marine , Popsuishapka Olexii , Ryndenko Victor , Kursov Sergiy , Babalian Volodymyr , Bohuslavska Nataliia
Published: April 2021

The relevance of the topic is due to the prevalence of lower limbs injuries in people of working age, the complexity of the methods of their surgical treatment and the problem of finding the optimal method of anesthesia in terms of efficiency and safety.
Objective of the study: to conduct a systematic analysis of modern scientific literature data on the possibility of using anesthesia methods during surgical interventions and in the case of anesthesia for injuries of the lower limbs in people of working age.
Materials and methods. A search for scientific sources was carried out in the scientometric databases Scopus and Web of Science, Google Scholar, archives of journals using the keywords "general anesthesia", "regional anesthesia", "injuries of the lower limbs", "young people", "general anesthesia". The search depth was 8 years.
Conclusions. The problem of choosing the method of anesthesia during traumatological surgeries in people of working age has no final solution. In general, both general and regional anesthesia can be used, despite their advantages and the possibility of complications in each case. However, in clinical practice over the past decade, general anesthesia is not always the best method of pain relief. But regional methods have less effect on the vital functions of the body, and the use of ultrasound navigation and modern local anesthetics in a minimum sufficient amount makes anesthesia conduction more effective and safe. The disadvantages of regional anesthesia can be avoided by combining it with general anesthesia. However, in the available literature, there are no recommendations on the differentiated choice of the method of anesthesia for surgical interventions on the lower limbs in people of working age and the factors that influence this
Features of the "education standardization" concept as a component of the research vocabulary for studying the foundations of the medical and pharmaceutical education development
Authors: Radziievska Iryna
Published: April 2021

The research analyses the legislative framework and scientific sources on the interpretation of the concepts of "educational standards" and "standardization of education" as components of the research vocabulary for studying the foundations of medical and pharmaceutical education development. The study of Ukrainian and foreign regulatory documents and scientific and pedagogical developments of medical scientists and educators has been conducted on the basis of a systematic generalizing approach. The sequence of the terms "educational standards" and "standardization of education" introduction in the Ukrainian education system is considered. Differences in the interpretation of the concept of "educational standards" from the point of view of the meaning that a particular organization (or person) puts into the definition of this concept are presented. It is indicated, that higher medical and pharmaceutical educational institutions still have educational standards, developed on the basis of an activity-based approach, which cannot fully satisfy the pedagogical and medical educational community. The paper studies the imperfection of the legislative framework in the State regarding the development of educational standards, the lack of educational standards for medical and pharmaceutical specialists of the junior specialist (junior Bachelor) educational level. Since the European and in Ukrainian education systems focus on the educational process, aimed at the development of employees' ability to solve practical problems in various fields of activity on the basis of acquired theoretical knowledge, the priority direction of the state educational policy for the development of educational standards for medical and pharmaceutical educational institutions is the need for a competence-oriented approach. The research states that updating the educational legislation, improving and modernizing the educational system and introducing a new generation of state education standards, will help increase the competitiveness of medical and pharmaceutical specialists in the labor market