bluuebunny/crossref_metadata_2025 huggingface dataset:
Ultra-Early Treatment of Neurosurgical Emergencies with Endoscopic Endonasal Approach: Experience from Three Italian Referral Centers
Authors: Mattogno Pier Paolo , Zoli Matteo , D’Alessandris Quintino Giorgio , Bongetta Daniele , Caccavella Valerio Maria , Rigante Mario , Della Pepa Giuseppe Maria , Mazzatenta Diego , Lauretti Liverana , Olivi Alessandro , Spena Giannantonio , Zoia Cesare
Published: August 2023

Purpose: the aim of this multicenter study is to preliminarily assess the role of the Endoscopic Endonasal Approach (EEA) in ultra-early (i.e., within 12 h) management of selected neurosurgical emergencies in terms of clinical and radiological outcomes. Methods: 26 patients affected by sellar/parasellar pathologies with rapid progression of symptoms were managed with EEA within 12 h from diagnosis in three Italian tertiary referral Centers from January 2016 to December 2019. Both clinical and radiological data have been collected preoperatively as well as post-operatively in order to perform retrospective analysis. Results: The average time from admission to the operating room was 5.5 h (±2.3). The extent of resection was gross-total in 20 (76.9%), subtotal in 6 (23.1%) patients. One patient experienced re-bleeding after a subtotal removal of a hemorrhagic lesion. Patients with a longer time from admission (>4 h) to the operatory room (OR) experienced stable impairment of the visual acuity (p = 0.033) and visual field (p = 0.029) in the post-operative setting. Conclusions: The Endoscopic Endonasal Approach represents a safe, effective technique that can be efficiently used with good results in the management of selected neurosurgical emergencies in centers with adequate experience.
Immunohistochemical Expression of Upregulated Gene 4 Protein Expression (URG4/URGCP) and Its Association with 5-Year Survival in Patients with Colon Adenocarcinoma
Authors: Brzozowa-Zasada Marlena , Piecuch Adam , Michalski Marek , Stęplewska Katarzyna , Matysiak Natalia , Kucharzewski Marek
Published: August 2023

(1) Background: Colorectal cancer (CRC) is the third most common cancer in terms of incidence and mortality. Approximately 90% of all colorectal cancer cases are adenocarcinomas, originating from epithelial cells of the colorectal mucosa. Upregulated gene 4 (URG4) is an oncogene involved in cancer development. The aim of the study was to assess the immunohistochemical expression of URG4 protein expression in Polish patients with colon adenocarcinoma who were not treated with any therapy before radical surgery. (2) Methods: The study used colon tissue samples taken from people with a confirmed diagnosis of colorectal adenocarcinoma after a thorough histopathological examination. The associations between the immunohistochemical expression of URG4 and clinical parameters were analyzed by the Chi2 test or Chi2Yatesa test. The study conducted an analysis of the correlation between the expression of URG4 and the five-year survival rate of patients through the application of the Kaplan–Meier analysis and the log-rank statistical test. The intracellular localization of URG4 was identified through the utilization of transmission electron microscopy (TEM) methodology. (3) Results: In univariate Cox regression analyses, immuno-histochemical expression of URG4, grade of histological differentiation, depth of invasion, angioinvasion, PCNA expression, stage of disease and lymph node involvement were found to be significant prognostic factors. Within our patient cohort, it was observed that the degree of tumour differentiation and URG4 expression were found to be distinct prognostic factors in regard to the 5-year survival rates of those with colon adenocarcinoma. (4) Conclusions: High immunohistochemical expression of URG4 correlates with poor prognosis in patients with colon adenocarcinoma.
Frequency and Distribution of Broncho-Alveolar Fungi in Lung Diseases in Martinique
Authors: Agossou Moustapha , Inamo Jocelyn , Ahouansou Nelly , Dufeal Marion , Provost Mathilde , Badaran Elena , Zouzou Adel , Awanou Bérénice , Dramé Moustapha , Desbois-Nogard Nicole
Published: August 2023

The microbiota refers to all the microorganisms living in and on the human body; its fungal component is known as the mycobiota. The molecular component (mycobiome) has been linked to certain pulmonary diseases. Morphological fungal examination is still common practice and makes it possible to isolate fungi on direct examination or after sample culture. This study aimed to identify fungi via the genus colonising the respiratory tract in our environment and to evaluate the relationship between identified fungi and underlying diseases. We performed a retrospective study of patients who underwent bronchofiberoscopy and mycological analysis of fluid collected by broncho-alveolar lavage at our centre over a period of 5 years. During the study period, 1588 samples from 1547 patients were analysed (50.7% male, mean age 63.7 ± 14.8 years). Among the 1588 samples, 213 (13.4%) were positive on direct examination, and 1282 (80.8%) were positive after culture. The average number of species detected per sample was 1.4 ± 1.1. For patients with positive fungus, the median was two (ranging from one to seven). At least three fungal species were isolated in 14.4% of samples (17.9% of positive cultures), and at least two were isolated in 41.2% of samples (51.1% of positive cultures). Sterile mycelium was observed in 671 samples (42.28%), while Candida was identified in 607 samples (38.25%), and Geotrichum was identified in 271 samples (17.08%). Moulds were more frequently associated with bronchiectasis, while yeasts were associated with infectious pneumonia. Both moulds and yeasts were less frequent in diffuse interstitial lung disease, and yeast was less frequently present in chronic cough. Although overall, sterile mycelium and Candida were most frequently observed regardless of the underlying disease, there was nonetheless significant variability in the fungal genera between diseases. Fungal spores are highly prevalent in respiratory samples in Martinique. The species present in the samples varied according to the underlying respiratory disease.
Safety and Efficacy of Vaptans in the Treatment of Hyponatremia from Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH): A Systematic Review and Meta-Analysis
Authors: Krisanapan Pajaree , Tangpanithandee Supawit , Thongprayoon Charat , Pattharanitima Pattharawin , Kleindienst Andrea , Miao Jing , Craici Iasmina M. , Mao Michael A. , Cheungpasitporn Wisit
Published: August 2023

The utilization of vasopressin receptor antagonists, known as vaptans, in the management of hyponatremia among patients afflicted with the syndrome of inappropriate antidiuretic hormone (SIADH) remains a contentious subject. This meta-analysis aimed to evaluate the safety and efficacy of vaptans for treating chronic hyponatremia in adult SIADH patients. Clinical trials and observational studies were identified by a systematic search using MEDLINE, EMBASE, and Cochrane Database from inception through September 2022. The inclusion criteria were the studies that reported vaptans’ safety or efficacy outcomes compared to placebo or standard therapies. The study protocol was registered with the International Prospective Register of Systematic Reviews (PROSPERO; CRD 42022357307). Five studies were identified, comprising three RCTs and two cohort studies, enrolling a total of 1840 participants. Regarding short-term efficacy on days 4–5, vaptans exhibited a significant increase in serum sodium concentration from the baseline in comparison to the control group, with a weighted mean difference of 4.77 mmol/L (95% CI, 3.57, 5.96; I2 = 34%). In terms of safety outcomes, the pooled incidence rates of overcorrection were 13.1% (95% CI 4.3, 33.6; I2 = 92%) in the vaptans group and 3.3% (95% CI 1.6, 6.6; I2 = 27%) in the control group. Despite the higher correction rate linked to vaptans, with an OR of 5.72 (95% CI 3.38, 9.70; I2 = 0%), no cases of osmotic demyelination syndrome were observed. Our meta-analysis comprehensively summarizes the efficacy and effect size of vaptans in managing SIADH. While vaptans effectively raise the serum sodium concentration compared to placebo/fluid restriction, clinicians should exercise caution regarding the potential for overcorrection.
Analysis of Physical–Cognitive Tasks Including Feedback-Based Technology for Alzheimer’s Disorder in a Randomized Experimental Pilot Study
Authors: Benitez-Lugo Maria-Luisa , Vazquez-Marrufo Manuel , Pinero-Pinto Elena , Chamorro-Moriana Gema , Perez-Cabezas Veronica , Suarez-Serrano Carmen
Published: August 2023

Introduction: Alzheimer’s disease causes great changes, with the prefrontal cortex being the most frequently damaged zone; these changes affect physical and cognitive behavior and compromise autonomy. Objective: The objective of this study was to evaluate the effects of physical–cognitive tasks on memory, attention, balance, gait, and risk of falling in Alzheimer’s by using feedback-based technology. Methods: Forty patients with Alzheimer’s were recruited from an Alzheimer’s Association; of these, 15 met the inclusion criteria and were included in the pilot RCT (eight in the control group; seven in the experimental group). Assessment tools: The Cognitive Mini-Examination Scale, Oddball Test and Attention Network, Berg Scale, Tinetti, Timed Up and Go, and Geriatric Deterioration Scale. The experimental group was treated with physical–cognitive tasks by using combined feedback-based technology (visual, acoustic, simultaneous, immediate, and terminal feedback, as well as knowledge of the results and performance) under the supervision of physiotherapists twice per week for 16 thirty-minute sessions. The control group underwent their usual care (pharmacological treatment, mobility exercises, and cognitive stimulation sessions). Result: In the experimental group, the contrast tests showed differences for the re-test (except in attention), with the significative Timed Up and Go test being significant (p = 0.020). The interaction between groups showed significant differences for the experimental group according to the MEC (p = 0.029; d = 0.14) and Tinetti (p = 0.029; d = 0.68). Discussion/Conclusion: Memory, balance, gait, and risk of falling improved in the Alzheimer’s patients through the use of physical–cognitive tasks involving combined feedback-based technology. The effects on attention were inconclusive. The outcomes should be treated with caution due to the sample. This can promote intergenerational bonds, use at home, and adherence to treatment.
Clinical Characteristics of Eyes with Neovascular Age-Related Macular Degeneration and Retinal Pigment Epithelium Tears
Authors: Nagata Junya , Shiose Satomi , Ishikawa Keijiro , Fukui Takuma , Kano Kumiko , Mori Kenichiro , Nakama Takahito , Notomi Shoji , Sonoda Koh-Hei
Published: August 2023

Background: Although anti-vascular endothelial growth factor (anti-VEGF) therapy is the first choice of treatment for eyes with neovascular age-related macular degeneration (AMD), it sometimes results in retinal pigment epithelium (RPE) tears. This study presents the detailed clinical characteristics of RPE tears to help predict their occurrence before anti-VEGF therapy initiation. Methods: This study retrospectively analyzed neovascular age-related macular degeneration (nAMD) patients who visited the Kyushu University Hospital and started anti-VEGF therapy between April 2013 and June 2020. Using medical records, we collected the clinical data of patients with RPE tears, including age, sex, best-corrected visual acuity (BCVA), number of anti-VEGF drug injections and the type and size of pigment epithelial detachment (PED). Results: RPE tears occurred in 16 (1.50%) eyes of 16 patients in all 1068 nAMD eyes of 987 patients. The mean age of these patients with RPE tear was 81.7 ± 8.7 years. Fifteen eyes had typical AMD and one eye had polypoidal choroidal vasculopathy. The mean number of anti-VEGF drug injections before RPE tears was 5.0 ± 5.1. All patients experienced PED before the RPE tear (hemorrhagic, 4 eyes; serous vascular, 2 eyes; fibrovascular, 10 eyes). The average PED height and area were 615.7 ± 175.3 μm and 21.0 ± 7.2 mm2, respectively. The sub-RPE cleft was observed in 10 eyes. The logMAR BCVA immediately after the RPE tear (0.73 ± 0.40) at 6 months (0.86 ± 0.51) and 12 months (0.84 ± 0.43) after the RPE tear were significantly worse than that before the RPE tear (0.58 ± 0.31; p < 0.05). The BCVA of patients with RPE tears that spread to the fovea was poorer than that of patients without RPE tears. Conclusions: In patients with nAMD, RPE tears tended to occur in typical AMD eyes with high or large PEDs, and sub-RPE clefts. The visual prognosis depended on whether the RPE tear included the fovea.
Advances in the Relationship between Respiratory Viruses and Asthma
Authors: Romero-Tapia Sergio , Guzmán Priego Crystell , Del-Río-Navarro Blanca , Sánchez-Solis Manuel
Published: August 2023

Several studies have reported that viral infection is closely associated with the onset, progression, and exacerbation of asthma. The purpose of this review is to summarize the role that viral infections have in the pathogenesis of asthma onset and exacerbations, as well as discuss interrelated protective and risk factors of asthma and current treatment options. Furthermore, we present current knowledge of the innate immunological pathways driving host defense, including changes in the epithelial barrier. In addition, we highlight the importance of the genetics and epigenetics of asthma and virus susceptibility. Moreover, the involvement of virus etiology from bronchiolitis and childhood wheezing to asthma is described. The characterization and mechanisms of action of the respiratory viruses most frequently related to asthma are mentioned.
The Impact of the Second Wave of the COVID-19 Pandemic on Non-COVID Hospital Care in a Tertiary Hospital in Spain
Authors: Gasch-Illescas Antonia , Andrade-Arroyo María , Vallejo-Vaz Antonio J. , Praena-Fernández Juan M. , Guerrero José A. , Calderón Enrique J. , Pollán Marina , Medrano Francisco J.
Published: August 2023

In 2020, Spain ranked fourth among European countries with the highest excess mortality due to COVID-19 disease. This study evaluates the impact of the COVID-19 pandemic on non-COVID patients in a tertiary hospital during the second pandemic wave in Spain (22 June 2020–6 December 2020). Data from Virgen del Rocío University Hospital in Seville during that timeframe were compared with the data from the same period in the preceding two years (2018–2019). Between-group comparisons were performed using the Chi-squared test, Student’s t-test, or Mann–Whitney U tests, as appropriate. A total of 63,137 non-COVID patients were included in this study. During the second pandemic wave, a 19% decrease was observed in the annual number of non-COVID admissions overall (18,260 vs. 22,439, p < 0.001), but a 10% increase in the proportion of emergency admissions (60.6% vs. 54.93%, p < 0.001), a higher severity level of patients (1.79 vs. 1.72, p < 0.001), a longer in-hospital stay (7.02 vs. 6.74 days, p < 0.001), a 26% increase in non-COVID mortality (4.9% vs. 3.9%, p < 0.001), and a 50% increase in global mortality (5.9 vs. 3.9, p < 0.001) were also observed. In terms of both medical and surgical diagnoses, a significant reduction in the number of admissions and an increase in in-hospital mortality were observed. These results demonstrate the significant impact of the pandemic on hospital care, similar to what was previously observed during the initial wave in the same hospital. Our findings emphasize the need to include non-COVID patients when assessing the broad impact of the pandemic on healthcare, beyond its direct effects on COVID-19 patients.
Electrical Conductivity and pH Are Two of the Main Factors Influencing the Composition of Arbuscular Mycorrhizal Fungal Communities in the Vegetation Succession Series of Songnen Saline-Alkali Grassland
Authors: Fang Lin-Lin , Liu Ya-Jie , Wang Zi-He , Lu Xiao-Yu , Li Jin-Hua , Yang Chun-Xue
Published: August 2023

Arbuscular mycorrhizal fungi (AMF) are widely distributed microorganisms in the soil, playing an important role in vegetation succession, plant community diversity, and improving soil physicochemical properties. In this study, morphological identification and high-throughput sequencing technology were used to comprehensively analyze the AMF community composition and diversity at different succession stages of Songnen saline-alkali grassland. To determine the root colonization status of plants collected in the field, a colonization system was established using late-succession plants as host plants to verify the existence of mycorrhizal symbiosis and the matching phenomenon of AMF in Songnen saline-alkali grassland. The results indicated that both morphological methods and high-throughput sequencing technology showed that glomus was the dominant genus of AMF in Songnen saline grassland. Redundancy analysis (RDA) and linear regression analysis showed that electrical conductivity (EC) and pH were the main environmental factors affecting AMF species diversity and community structure in the succession sequence of Songnen saline grassland. In addition, the results of root colonization identification and the colonization system test in the field showed that AMF successfully colonized vegetation at different succession stages and had mycorrhizal symbiosis. The results of this study could help to understand the AMF community of Songnen saline-alkali grassland as well as provide a reference and basis for optimizing the AMF community structure of Songnen saline-alkali grassland through human intervention in the future and using mycorrhizal technology to restore and rebuild the degraded ecosystem of Songnen saline-alkali grassland.
The Adaptation of Botrytis cinerea Extracellular Vesicles Proteome to Surrounding Conditions: Revealing New Tools for Its Infection Process
Authors: Escobar-Niño Almudena , Harzen Anne , Stolze Sara C. , Nakagami Hirofumi , Fernández-Acero Francisco J.
Published: August 2023

Extracellular vesicles (EVs) are membranous particles released by different organisms. EVs carry several sets of macromolecules implicated in cell communication. EVs have become a relevant topic in the study of pathogenic fungi due to their relationship with fungal–host interactions. One of the essential research areas in this field is the characterization protein profile of EVs since plant fungal pathogens rely heavily on secreted proteins to invade their hosts. However, EVs of Botrytis cinerea are little known, which is one of the most devastating phytopathogenic fungi. The present study has two main objectives: the characterization of B. cinerea EVs proteome changes under two pathogenic conditions and the description of their potential role during the infective process. All the experimental procedure was conducted in B. cinerea growing in a minimal salt medium supplemented with glucose as a constitutive stage and deproteinized tomato cell walls (TCW) as a virulence inductor. The isolation of EVs was performed by differential centrifugation, filtration, ultrafiltration, and sucrose cushion ultracentrifugation. EVs fractions were visualised by TEM using negative staining. Proteomic analysis of EVs cargo was addressed by LC-MS/MS. The methodology used allowed the correct isolation of B. cinerea EVs and the identification of a high number of EV proteins, including potential EV markers. The isolated EVs displayed differences in morphology under both assayed conditions. GO analysis of EV proteins showed enrichment in cell wall metabolism and proteolysis under TCW. KEGG analysis also showed the difference in EVs function under both conditions, highlighting the presence of potential virulence/pathogenic factors implicated in cell wall metabolism, among others. This work describes the first evidence of EVs protein cargo adaptation in B. cinerea, which seems to play an essential role in its infection process, sharing crucial functions with the conventional secretion pathways.
Small Cationic Cysteine-Rich Defensin-Derived Antifungal Peptide Controls White Mold in Soybean
Authors: Djami-Tchatchou Arnaud Thierry , Tetorya Meenakshi , Godwin James , Codjoe Jennette M. , Li Hui , Shah Dilip M.
Published: August 2023

White mold disease caused by a necrotrophic ascomycete pathogen Sclerotinia sclerotiorum results in serious economic losses of soybean yield in the USA. Lack of effective genetic resistance to this disease in soybean germplasm and increasing pathogen resistance to fungicides makes white mold difficult to manage. Small cysteine-rich antifungal peptides with multi-faceted modes of action possess potential for development as sustainable spray-on bio-fungicides. We have previously reported that GMA4CG_V6 peptide, a 17-amino acid variant of the MtDef4 defensin-derived peptide GMA4CG containing the active γ-core motif, exhibits potent antifungal activity against the gray mold fungal pathogen Botrytis cinerea in vitro and in planta. GMA4CG_V6 exhibited antifungal activity against an aggressive field isolate of S. sclerotiorum 555 in vitro with an MIC value of 24 µM. At this concentration, internalization of this peptide into fungal cells occurred prior to discernible membrane permeabilization. GMA4CG_V6 markedly reduced white mold disease symptoms when applied to detached soybean leaves, pods, and stems. Its spray application on soybean plants provided robust control of this disease. GMA4CG_V6 at sub-lethal concentrations reduced sclerotia production. It was also non-phytotoxic to soybean plants. Our results demonstrate that GMA4CG_V6 peptide has potential for development as a bio-fungicide for white mold control in soybean.
Pitaya Juice Consumption Protects against Oxidative Damage Induced by Aflatoxin B1
Authors: Madalosso Luiggi Müller , Balok Franciéle Romero Machado , Bortolotto Vandreza Cardoso , Dahleh Mustafa Munir Mustafa , Backes Lucas Gabriel , Escalante Elizabeth Sabryna Sarquis , Benites Fernanda Vilhalba , da Silva e Silva Francisco Andrey , Segat Hecson Jesser , Boeira Silvana Peterini
Published: August 2023

Mycotoxins are toxic fungal metabolites and are responsible for contaminating several foods. The intake of foods contaminated by these substances is related to hepatotoxicity and carcinogenic effects, possibly due to increasing oxidative stress. The current study evaluated Pitaya fruit juice’s antioxidant effects on oxidative damage aflatoxin B1 (AFB1)-induced. Rats received 1.5 mL of Pitaya juice via gavage (for 30 days), and on the 31st day, they received AFB1 (250 µg/kg, via gavage). Forty-eight hours after the AFB1 dose, rats were euthanized for dosages of alanine transaminase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP); dosage of oxidative markers (thiobarbituric acid reactive species (TBARS), reactive species (RS)) and antioxidant defenses (catalase (CAT), superoxide dismutase (SOD), Glutathione S-transferase (GST) activities and Glutathione (GSH)) levels in the liver; and detection of Heat shock protein 70 (Hsp-70) and nuclear factor- erythroid 2-related factor 2 (Nrf2) immunocontent in the liver. Our results indicated that the Pitaya juice reduced ALP activity. Further, rats exposed to AFB1 experienced liver damage due to the increase in TBARS, RS, and Hsp-70 and the reduction in CAT, GSH, and Nrf2. Pitaya juice could, however, protect against these damages. Finally, these results indicated that pre-treatment with Pitaya juice was effective against the oxidative damage induced. However, other aspects may be elucidated in the future to discover more targets of its action against mycotoxicosis.
YAP Activation Is Associated with a Worse Prognosis of Poorly Cohesive Gastric Cancer
Authors: Bencivenga Maria , Torroni Lorena , Dal Cero Mariagiulia , Quinzii Alberto , Zecchetto Camilla , Merz Valeria , Casalino Simona , Taus Francesco , Pietrobono Silvia , Mangiameli Domenico , Filippini Federica , Alloggio Mariella , Castelli Claudia , Iglesias Mar , Pera Manuel , Melisi Davide
Published: August 2023

Poorly cohesive (PC) gastric cancer (GC) is extremely aggressive in progression, and there is an urgent need to identify the molecular pathways involved. We hypothesized the essential role of the RhoA–YAP axis in these mechanisms. The present observational multicenter retrospective study included 133 patients with PC GC treated at two dedicated European surgical centers between 2004 and 2014. YAP nuclear localization was measured by immunohistochemical (IHC) analysis of tissue biopsies. The complete absence of nuclear reactivity was coded as negative expression; we considered “any positive” as low nuclear expression (>0% but <10% of cells) and high nuclear expression (≥10% of cells). Women represented about half of the present series (52%), and the median age was 64 years (p25–p75 range: 53–75). Neoadjuvant and adjuvant treatments were administered to 10% and 54% of the cases, respectively. Extended systemic lymphadenectomy (D2) was the most common (54%). In nearly all cases, the number of retrieved nodes was ≥15, i.e., adequate for tumor staging (94%). An R0 resection was achieved in 80% of the cases. Most patients were pathological T stage 3 and 4 (pT3/pT4 = 79.0%) and pathological N stage 2, 3a, and 3b (pN2/pN3a/pN3b = 47.0%) at the pathological examination. Twenty patients (15%) presented distant metastases. Five-year overall survival (OS) was significantly higher (p = 0.029) in patients with negative YAP (46%, 95% CI 31.1–60.0%) than in the other patients (27%, 17.5–38.1%). Moreover, when controlling for sex, age, pT, pN, and percentage of signet ring cells in the multivariable analysis, YAP expression was a significant predictor of OS (HR 2.03, 95% CI: 1.18–3.51, p = 0.011). Our results provide new insights into the role of the YAP signaling cascade, as its activation was associated with a worse prognosis in PC GC.
Determining the Appropriate Accounting Treatment of Cryptocurrencies Based on Accounting Theory
Authors: Klopper Nicolette , Brink Sophia Magaretha
Published: August 2023

The International Financial Reporting Standards (IFRS) do not make explicit provisions, in terms of a specifically dedicated standard, for the accounting treatment of cryptocurrencies. This creates uncertainty, and guidance is therefore required in terms of accounting for such investments. Accounting theory has the potential to provide the foundation for this guidance. This study aimed to determine the most appropriate accounting treatment for cryptocurrencies based on the International Accounting Standards Board’s (IASB) Conceptual Framework for Financial Reporting (as a form of accounting theory) that results in decision-useful information. The research further investigated the proposed accounting treatment in terms of IFRS and sought to determine whether this treatment was aligned with the IASB’s conceptual framework. This qualitative study conducted a non-empirical interpretative analysis of the literature (focusing specifically on accounting theory) to address the research aim. The conceptual framework indicated that the most appropriate way to account for cryptocurrencies was to recognise an asset at fair value. This accounting treatment aligns with accounting for assets under International Accounting Standard (IAS) 2 commodities held by broker-traders and the IAS 38 revaluation model. Addressing the problem of accounting for cryptocurrencies with reference to accounting theory makes this study novel. The guidance provided could reduce uncertainty among entities holding investments in cryptocurrencies and could increase the decision-usefulness of financial information.
Spatiotemporal-Behavior-Based Microsegregation and Differentiated Community Ties of Residents with Different Types of Housing in Mixed-Housing Neighborhoods: A Case Study of Fuzhou, China
Authors: Zhang Xue , Tang Yifan , Chai Yanwei
Published: August 2023

As a kind of urban neighborhood with strong internal heterogeneity, mixed-housing neighborhoods have attracted wide attention from scholars in recent years. Strengthening community ties in mixed-housing neighborhoods is of great significance for increasing neighborhood social capital, cultivating a sense of community, and promoting sustainable development of the neighborhood. The neighborhood activities of residents are an important factor in promoting community ties. However, different housing groups in mixed-housing neighborhoods may have differentiated or even segregated overall daily activities, which may impact their neighborhood activities and call for differentiated planning strategies. In this study, we conduct an empirical study in Fuzhou, China, to identify the spatiotemporal-behavior-based microsegregation and differentiated community ties between residents of different types of housing. The data were collected in 2021 and included residents’ activity diary data and questionnaire data about neighborhood interaction and community ties. Through an analysis of the daily overall activity space and activities within the neighborhood areas, the spatiotemporal-behavior-based social segregation of various housing groups is depicted. Furthermore, a multigroup structural equation modeling method was used to analyze the relationships among residents’ spatiotemporal behaviors, neighborhood interactions, and community ties, and the heterogeneous influence effects across housing groups. The results show that the more residents’ activity spaces overlap with the neighborhood area, the more out-of-home time they spend within the neighborhood, and that the more types of activities are conducted within the neighborhood area, the stronger their community ties are. In addition, neighborhood interaction played a linkage role in the relationships of residents’ spatiotemporal behaviors and community ties. Our research aims to further the understanding of microsegregation at the neighborhood level and provide references for the development of mixed-housing neighborhoods and urban land use.
The Land-Use and Land-Cover Changes in the Este District, South Gondar Zone, Northwestern Ethiopia, in the Last Four Decades (the 1980s to 2020s)
Authors: Gashaye Dilnessa , Woldu Zerihun , Nemomissa Sileshi , Adgo Enyew
Published: August 2023

Environmental transformations are the results of land-use and land-cover (LULC) changes. This study aims to investigate the LULC changes and associated factors in the Este District in northwestern Ethiopia, for the last four decades (the 1980s to 2020s). The land-use and land-cover classes were analyzed using supervised classification techniques in ERDASS IMAGINE 2015 and ArcGIS 10.3.1, categorizing the Landsat satellite images for 1984, 2000, and 2018 into six cover classes: settlement, forests-shrublands, cropland, grassland, bare land, and water body. We used a historical Google map, topo-sheets, and ancillary data to verify the classification accuracies for 1984, 2000, and 2018, respectively. The climate and demographic data were obtained from the Ethiopian Meteorological Station and Ethiopian Statistical Agency, respectively. In addition, data from key informant interviews and focus group discussions were also used to understand the local community experiences and perceptions toward LULC changes. The values of each LULC class were correlated with the demographic and climatic variables, using simple correlation analysis to evaluate the impact of demographic and climatic conditions on LULC changes. The analysis indicated that the least and largest classes of LULC in Este District were water bodies (mean cover = 1.9 km2) and croplands (mean cover = 791.7 km2), respectively. Cropland coverage increased by 2% in 2000, then decreased by 11% in 2018. Between 1984 and 2018, the grasslands and settlements increased by 22% and 0.5%, respectively. Half of the bare land and one-tenth of the forests-shrublands also decreased over the last four decades (the 1980s to 2020s). As a result, the original croplands and forests–shrublands classes (11% each) before 2000 were converted into new grasslands and croplands after 2018, respectively. The study indicated that precipitation, solar radiation, and population growth are the potential drivers, and the perceptions of local communities are nearly in line with the statistical analysis results. Alternative income sources, such as tourism and carbon trading and the participation in afforestation programs, could reverse the situation in the study area.
A Scenario-Based Spatial Multi-Criteria Decision-Making System for Urban Environment Quality Assessment: Case Study of Tehran
Authors: Moradi Bahare , Akbari Rojin , Taghavi Seyedeh Reyhaneh , Fardad Farnaz , Esmailzadeh Abdulsalam , Ahmadi Mohammad Zia , Attarroshan Sina , Nickravesh Fatemeh , Jokar Arsanjani Jamal , Amirkhani Mehdi , Martek Igor
Published: August 2023

Spatial evaluation of urban environment quality (UEQ) is a key prerequisite in urban planning and development. The main goal of this study is to present a scenario-based spatial multi-criteria decision-making system for evaluating UEQ. Therefore, stakeholder involvement was conducted and eight environmental criteria and six spatial-functional criteria were identified for five districts of Tehran. The weight of the effective criteria was calculated using the analytic hierarchy process (AHP) model. Then, the ordered weighted averaging (OWA) model was used to prepare UEQ maps in different scenarios, including very pessimistic, pessimistic, intermediate, optimistic, and very optimistic. Finally, the spatial distribution of the district population in different classes of UEQ was evaluated. Among the spatial-functional and environmental criteria, the sub-criteria of population density and air pollution, respectively, had the greatest impact on UEQ. In very pessimistic, intermediate, optimistic, and very optimistic scenarios, approximately 76.7, 51.8, 36.4, 23.7, and 9.8 km2 of the studied area had unsuitable UEQ conditions, respectively. In the very pessimistic scenario, about 37,000 and 1,500,000 people lived in areas with suitable and unsuitable UEQ conditions, respectively. In the very optimistic scenario, the population increased to over 917,000 in areas with suitable UEQ and decreased to 336,000 in those with unsuitable UEQ conditions in terms of both environmental and spatial-functional criteria. The research results showed that a high percentage of the population in the study area live under unsuitable UEQ conditions, which indicates the need for attention to improving the current UEQ conditions. The proposed approach is timely to gain a better understanding of the adverse impact of climate change on human well-being in marginal societies and how climate-resilient urban planning can play a significant role.
Valuing the Accessibility of Green Spaces in the Housing Market: A Spatial Hedonic Analysis in Shanghai, China
Authors: Ben Shenglin , Zhu He , Lu Jiajun , Wang Renfeng
Published: August 2023

As a crucial determinant of urban livability, the importance of access to high-quality green spaces has long been recognized for achieving sustainable urbanization. In urban areas, higher values are usually placed in residential properties with higher accessibility to green spaces. Using housing transaction data from as many as 3388 residential communities in Shanghai coupled with high-resolution satellite data of urban green spaces, we comprehensively examine the relationship between residential property values and the accessibility of both community-owned and public green spaces. We find, in instrumental-variable estimations, that: (1) home prices, on average, increase by 0.17% if the overall green space accessibility rises by 1%; and that (2) a 1% increase in the green ratio within a community raises property values by 0.46%. Moreover, the number of accessible green spaces, area of accessible green spaces, and distance to the nearest green spaces have positive impacts on home values separately. We also find strong spatial dependence in urban green spaces and unobserved price determinants, as well as heterogeneity by location, property value, and housing type. Our empirical findings provide valuable guidance for real estate developers and local governments in valuing environmental amenities and urban planning in the context of a residential housing market.
Novel Compounds Derived from DFPM Induce Root Growth Arrest through the Specific VICTR Alleles of Arabidopsis Accessions
Authors: Kim Seojung , Cho Miri , Kim Tae-Houn
Published: August 2023

The small compound [5-(3,4-dichlorophenyl) furan-2-yl]-piperidine-1-ylmethanethione (DFPM) inhibits ABA responses by activating effector-triggered immune signal transduction in Arabidopsis. In addition to the known function of DFPM as an antagonist of ABA signaling, DFPM causes accession-specific root growth arrest in Arabidopsis Columbia-0 via the TIR-NLR protein VICTR (VARIATION IN COMPOUND TRIGGERED ROOT growth response) in an EDS1/PAD4/RAR1/SGT1B-dependent manner. Although DFPM could control the specific steps of various cellular responses, the functional residues for the activity of DFPM or the existence of a stronger version of DFPM modification have not been characterized thoroughly. This study analyzed twenty-two DFPM derivatives during root growth arrest, inhibition of ABA signaling, and induction of biotic signal transduction to determine critical residues that confer the specific activity of DFPM. Furthermore, this study identified two more Arabidopsis accessions that generate significant root growth arrest in response to DFPM derivatives dependent on multiple amino acid polymorphisms in the coding region of VICTR. The isolation of novel compounds, such as DFPM-5, and specific amino acid polymorphisms critical for the compound-induced responses will help determine the detailed regulatory mechanism for how DFPM regulates abiotic and biotic stress signaling interactions.
Analgesic Effect of the Lysine-Containing Short Peptide Is Due to Modulation of the NaV1.8 Channel Activation Gating System
Authors: Kalinina Arina D. , Rogachevskii Ilya V. , Samosvat Dmitriy M. , Zegrya Georgy G. , Butkevich Irina P. , Mikhailenko Viktor A. , Plakhova Vera B. , Penniyaynen Valentina A. , Podzorova Svetlana A. , Krylov Boris V.
Published: August 2023

The present work continues our recent series of articles that aim to elucidate the ligand–receptor binding mechanism of short cationic peptides to the NaV1.8 channel in the nociceptive neuron. The applied methodological approach has involved several methods: the patch-clamp experimental evaluation of the effective charge of the NaV1.8 channel activation gating system, the organotypic tissue culture method, the formalin test, and theoretical conformational analysis. The lysine-containing short peptide Ac-KEKK-NH2 has been shown to effectively modulate the NaV1.8 channel activation gating system. As demonstrated by the organotypic tissue culture method, the studied short peptide does not trigger the downstream signaling cascades controlling neurite outgrowth and should not be expected to evoke adverse side effects. Conformational analysis of the Ac-KEKK-NH2 molecule has revealed that the distances between the positively charged amino groups of the lysine side chains are equal to 11–12 Å. According to the previously suggested mechanism of ligand–receptor binding of short peptides to the NaV1.8 channel molecule, Ac-KEKK-NH2 should exhibit an analgesic effect, which has been confirmed by the formalin test. The data obtained unequivocally indicate that the studied lysine-containing short peptide is a promising candidate for the role of a novel analgesic medicinal substance.
The Implications of a Dermatopathologist’s Report on Melanoma Diagnosis and Treatment
Authors: Nethanel Asher , Kyprianou Christofis , Barzilai Aviv , Shapira-Frommer Ronnie , Shoham Yaron , Kornhaber Rachel , Cleary Michelle , Avinoam-Dar Galit , Grynberg Shirly , Haik Josef , Debby Assaf , Harats Moti
Published: August 2023

An accurate and comprehensive histopathology report is essential for cutaneous melanoma management, providing critical information for accurate staging and risk estimation and determining the optimal surgical approach. In many institutions, a review of melanoma biopsy specimens by expert dermatopathologists is considered a necessary step. This study examined these reviews to determine the critical primary histopathology Breslow score in which a histopathology review would be most beneficial. Histopathology reports of patients referred to our institute between January 2011 and September 2019 were compared with our in-house review conducted by an expert dermatopathologist. The review focused on assessing fundamental histologic and clinical prognostic features. A total of 177 specimens underwent histopathology review. Significant changes in the Breslow index were identified in 103 cases (58.2%). Notably, in many of these cases (73.2%), the revised Breslow was higher than the initially reported score. Consequently, the T-stage was modified in 51 lesions (28.8%). Substantial discordance rates were observed in Tis (57%), T1b (59%), T3a (67%) and T4a (50%) classifications. The revised histopathology reports resulted in alterations to the surgical plan in 15.3% of the cases. These findings emphasize the importance of having all routine pathologies of pigmented lesions referred to a dedicated cancer center and reviewed by an experienced dermatopathologist. This recommendation is particularly crucial in instances where the histopathology review can potentially alter the diagnosis and treatment plan, such as in melanoma in situ and thinner melanomas measuring 0.6–2.2 mm in thickness. Our study highlights the significant impact of histopathology reviews in cutaneous melanoma cases. The observed changes in Breslow scores and subsequent modifications in T-stage classification underline the need for thorough evaluation by an expert dermatopathologist, especially in cases of melanoma in situ and thin melanomas. Incorporating such reviews into routine practice within dedicated cancer centers can improve diagnostic accuracy and guide appropriate treatment decisions, ultimately leading to better patient outcomes.
Formulation and Performance of Model Concrete in Reduced-Scale Physical Model Tests
Authors: Zheng Gang , Xia Boyang , Zhou Haizuo , Diao Yu , Huang Jianyou , Zhang Junbo , Yu Xiaoxuan
Published: August 2023

The utility of geotechnical centrifuge tests depends on how correctly they predict the physical and mechanical behaviour of concrete. In this study, a model concrete material that consisted of α-gypsum plaster, fine silica sand, and water was developed. An orthogonal test design was used to evaluate the effect of the mix proportion on the model concrete performance. The physical (i.e., flowability and bleeding rate) and mechanical (i.e., compressive and flexural strength) characteristics were considered as indices. Various mix ratios resulted in remarkable relative contributions to model concrete performance, and each raw material dosage exhibited positive or negative synergy. The water–plaster ratio (W/P) and aggregate–plaster ratio (A/P) strongly influenced the mechanical and physical characteristics, respectively. Multiple linear regression analysis (MLRA) was carried out to determine a forecast model for various small-scale test demands. Finally, the applicability and outlines of the presented forecasting method in proportioning design were evaluated by typical use of model concrete in small-scale model tests.
Understanding Machining Process Parameters and Optimization of High-Speed Turning of NiTi SMA Using Response Surface Method (RSM) and Genetic Algorithm (GA)
Authors: Zhao Yanzhe , Cui Li , Sivalingam Vinothkumar , Sun Jie
Published: August 2023

This study aimed to optimize machining parameters to obtain better surface roughness and remnant depth ratio values under dry turning of NiTi-shape memory alloy (SMA). During the turning experiments, various machining parameters were used, including three different cutting speeds vc (105, 144, and 200 m/min), three different feed rates f (0.05, 0.1, and 0.15 mm/rev), and three different depths of cut ap (0.1, 0.15, and 0.2 mm). The effects of machining parameters in turning experiments were investigated on the response surface methodology (RSM) with Box–Behnken design (BBD) using the Design Expert 11; how the cutting parameters affect the surface quality is discussed in detail. In this context, the cutting parameters were successfully optimized using a genetic algorithm (GA). The optimized processing parameters are vc = 126 m/min, f = 0.11 mm/rev, ap = 0.14 mm, resulting in surface roughness and remnant depth ratio values of 0.489 μm and 64.13%, respectively.
Recent Advances in the Preparation and Application of Two-Dimensional Nanomaterials
Authors: Guo Ying-Tong , Yi Sha-Sha
Published: August 2023

Two-dimensional nanomaterials (2D NMs), consisting of atoms or a near-atomic thickness with infinite transverse dimensions, possess unique structures, excellent physical properties, and tunable surface chemistry. They exhibit significant potential for development in the fields of sensing, renewable energy, and catalysis. This paper presents a comprehensive overview of the latest research findings on the preparation and application of 2D NMs. First, the article introduces the common synthesis methods of 2D NMs from both “top-down” and “bottom-up” perspectives, including mechanical exfoliation, ultrasonic-assisted liquid-phase exfoliation, ion intercalation, chemical vapor deposition, and hydrothermal techniques. In terms of the applications of 2D NMs, this study focuses on their potential in gas sensing, lithium-ion batteries, photodetection, electromagnetic wave absorption, photocatalysis, and electrocatalysis. Additionally, based on existing research, the article looks forward to the future development trends and possible challenges of 2D NMs. The significance of this work lies in its systematic summary of the recent advancements in the preparation methods and applications of 2D NMs.
Modeling Corrosion Product Film Formation and Hydrogen Diffusion at the Crack Tip of Austenitic Stainless Steel
Authors: Yang Fuqiang , Zhang Jianzhou , Zhang Yue
Published: August 2023

Corrosion product films (CPFs) have significant effects on hydrogen permeation and the corrosion process at the crack tip. This paper established a two-dimensional calculation model to simulate the formation of CPFs at the crack tip and its effects on the crack tip stress status and hydrogen diffusion. The CPFs were simplified as a single-layer structure composed of Fe2O3, the effective CPFs boundary was modeled by the diffusion of oxygen, and the CPF-induced stress was modeled by hygroscopic expansion. The simulation was conducted with two stages; the first stage was to simulate the formation of CPFs formation and its effects on the crack tip stress status, while the second stage focused on the hydrogen diffusion with and without CPF formation under different external tensile loads. The results indicate that the highest compressive stress induced by the formation of CPFs is located at 50~60° of the crack contour and dramatically weakens the crack tip tensile stress at low-stress status. The CPFs can inhibit the hydrogen permeation into the crack tip, and the hydrostatic pressure effects on the redistribution of the permeated hydrogen are significant under larger external load conditions.