bluuebunny/crossref_metadata_2025 huggingface dataset:
Chemical and Kinematic Properties of the Galactic Disk from the LAMOST and Gaia Sample Stars
Authors: Yan Yepeng , Du Cuihua , Liu Shuai , Li Hefan , Shi Jianrong , Chen Yuqin , Ma Jun , Wu Zhenyu
Published: July 2019

We determined the chemical and kinematic properties of the Galactic thin and thick disk using a sample of 307,246 A/F/G/K-type giant stars from the LAMOST spectroscopic survey and Gaia DR2 survey. Our study found that the thick disk globally exhibits no metallicity radial gradient, but the inner disk (R ≤ 8 kpc) and the outer disk (R > 8 kpc) have different gradients when they are studied separately. The thin disk also shows two different metallicity radial gradients for the inner disk and the outer disk, and has a steep metallicity vertical gradient of

dex kpc−1, which becomes flat when it is measured at increasing radial distance. The metallicity radial gradient on the other hand becomes weaker with increasing vertical distance. Adopting a Galaxy potential model, we derived the orbital eccentricity of sample stars and found a downtrend of average eccentricity with increasing metallicity for the thick disk. The variation of the rotation velocity with the metallicity shows a positive gradient for the thick disk stars and a negative one for the thin disk stars. Comparisons of our observed results with models of disk formation suggest that radial migration could have influenced the chemical evolution of the thin disk. The formation of the thick disk could be affected by more than one process: the accretion model could play an indispensable role, while other formation mechanisms, such as the radial-migration or disk-heating model could also have a contribution.
Y a-t-il une géopolitique du nationalisme hindou ?
Authors: Racine Jean-Luc
Published: July 2019

À la veille des élections législatives d’avril-mai 2019, l’heure du bilan a sonné pour le gouvernement de Narendra Modi. En matière de politique étrangère, on cherchera à éclairer ce bilan sous deux angles. Le premier fera l’inventaire des grands axes suivis depuis 2014, dans le voisinage proche marqué principalement par les tensions continues avec le Pakistan, mais aussi sur la scène mondiale où la multipolarité l’emporte sur le multilatéralisme. Dans l’un et l’autre champ, la montée en puissance de la Chine est un facteur structurant, qui explique l’intérêt de l’Inde pour le concept d’Indo-Pacifique, même si la règle reste la même, en faveur de partenariats, mais pas d’alliances. La deuxième approche rappelle ce que sont les fondements idéologiques du nationalisme hindou au pouvoir et s’interroge : cette idéologie a-t-elle marqué de façon décisive la géopolitique indienne sous le gouvernement Modi ? Pour nombre d’observateurs, au-delà des affichages du soft power , la continuité avec le gouvernement précédent reste forte.
Puissance et dépendance : l’Inde et les importations d’armement
Authors: Monsonis Guillem
Published: July 2019

L’Inde est aujourd’hui un des principaux importateurs d’armement au monde, sa base industrielle et technologique de défense (BITD) étant incapable de couvrir l’ensemble des besoins des forces. L’analyse de ses principaux partenariats est un bon indicateur de la nature et du niveau des dépendances actuelles de l’industrie indienne. La Russie et Israël sont devenus des partenaires stratégiques de l’Inde en s’imposant comme des fournisseurs de confiance répondant rapidement à ses besoins capacitaires. Les achats d’armements aux États-Unis sont quant à eux essentiellement motivés par des raisons diplomatiques et parce que Washington propose des capacités indisponibles ailleurs. Afin de réduire cette dépendance aux importations difficilement tenable à terme, le gouvernement de Narendra Modi a lancé un programme visant à faire entrer le secteur privé dans la BITD et à favoriser la conception et la production locales d’armement. Une politique qui peine cependant à produire des résultats et qui se heurte à l’urgence et l’amplitude des besoins des forces.
De la démocratie délibérative à la démocratie radicale ? Tirage au sort et politique au XXI e siècle
Authors: Sintomer Yves , Saint-Upéry Marc
Published: July 2019

Cet article soutient quatre thèses principales. La première est que ces dernières décennies, deux vagues d’innovations démocratiques basées sur le tirage au sort doivent être distinguées, s’appuyant sur des dispositifs concrets partiellement différents, incarnant des dynamiques sociales variées et dotés d’horizons démocratiques distincts. Le second argument est que la logique de la première vague d’innovations démocratiques reposant sur des mini-publics choisis au hasard se distingue notablement de la dynamique du tirage au sort politique à Athènes, car elle tend vers une dynamique de démocratie délibérative plutôt qu’une dynamique de démocratie radicale. À l’inverse, les processus de tirage au sort qui ont émergé durant la deuxième vague sont plus proches de l’esprit des traditions démocratiques radicales athéniennes. Le troisième argument est normatif : ces processus de sélection aléatoire avec pouvoir décisionnel sont plus prometteurs d’une véritable démocratisation de la démocratie. Enfin, le dernier argument soutient que tout projet de législatif tiré au sort doit s’inspirer de ces considérations au moment de défendre une perspective normativement convaincante et politiquement réaliste.
La première Convention constitutionnelle irlandaise (2013-2014) : un dispositif délibératif à forte légitimité ?
Authors: Suiter Jane , Farrell David M. , Harris Clodagh , O’Malley Eoin , Blandin Xavier
Published: July 2019

Cet article analyse le fonctionnement de la première Convention constitutionnelle irlandaise qui s’est tenue en 2013. On avait argumenté que recourir à une approche délibérative pour réformer la Constitution serait utile afin d’impliquer les citoyens dans les décisions tout en renforçant une légitimité démocratique affaiblie et en reconfigurant potentiellement la pratique démocratique. La Convention conduit à un référendum pour reconnaître l’égalité du droit au mariage (pour les personnes de même sexe) et l’Irlande devint le premier pays du monde à instituer ce droit par un vote populaire. Cet article examine toutes les facettes de la Convention à travers la grille d’analyse de la légitimité d’ input , de throughput et d’ output . Nos résultats montrent que deux des points qui furent initialement critiqués, la composition de la Convention et son mandat, se sont révélés innovants et ont contribué à sa légitimité sur de multiples dimensions.
Les postérités inattendues de Principes du gouvernement représentatif : une discussion avec Bernard Manin
Authors: Chollet Antoine , Bernard Manin
Published: July 2019

Le livre de Bernard Manin, Principes du gouvernement représentatif , a trouvé des lecteurs attentifs parmi les spécialistes du tirage au sort en politique, ainsi que chez ses militants. Les uns et les autres n’hésitent pas à en faire l’un des premiers plaidoyers en faveur de ce mode de désignation des magistrats, renversant ainsi le propos du livre. Dans cette discussion, Antoine Chollet tente de cerner les origines de ce malentendu, et Bernard Manin répond aux lectures qui ont été faites de son livre, tout en donnant les raisons qui l’ont poussé à accorder autant d’attention aux mécanismes de tirage au sort.
Conquêtes du sexuel infantile, conquêtes des limites : fonctions et intégrations du regard dans les troubles du spectre autistique
Authors: Suarez-Labat Hélène
Published: July 2019

Les méthodes projectives et leurs interprétations psychodynamiques rendent compte du traitement du sexuel infantile, de sa fonction de liaison chez les enfants présentant des troubles du spectre autistique. L’étude au Rorschach et au Scéno-Test de la construction des enveloppes psychiques et du développement des fonctions du regard permettent d’apprécier le déploiement de la qualité des limites internes et externes, du fond de soi, de la construction de la négation ainsi que la nature des relations entre sensations, affects et leurs symbolisations chez les différents groupes d’autismes.
Contribution des épreuves projectives à la question de la psychose pubertaire : le cas d’Amandine, 15 ans
Authors: Sleiman Haidar Haya , Marty François
Published: July 2019

L’adolescence est un processus dynamique qui entraine de profonds remaniements somatiques et psychiques et conduit l’adolescent vers un nécessaire travail de subjectivation. La psychose pubertaire, dans ce contexte critique, est une rupture du développement qui expose les fêlures de ce processus en révélant les potentialités psychotiques antérieures et en menaçant de faire dévier les chemins de la structuration. Après une brève réflexion théorique sur la notion de psychose pubertaire, comprise comme une double potentialité psychopathologique, ainsi qu’une présentation succincte de l’apport des travaux de l’École de Paris à la question de la psychose à l’adolescence, les auteurs illustrent leurs propos par l’étude clinique et projective du cas d’Amandine, patiente rencontrée dans le cadre d’une recherche doctorale. Les résultats montrent l’hétérogénéité de cette clinique sujette à des aménagements à la fois psychotiques et limites et mettent en évidence l’existence d’un mouvement mélancolique, point d’orgue pour la compréhension du déclenchement des pathologies adolescentes.
Adolescente en obésité, la féminité à l’épreuve du Rorschach : quand la médiation corporelle groupale engage le travail de la féminité par l’expression de l’agressivité
Authors: Morra Angelina , Picard Charlyne , Sanahuja Maria de la Almudena , Carrola-Manga Patricia
Published: July 2019

Nos observations mettent en évidence qu’au début d’un dispositif thérapeutique corporel et groupal, le corps en obésité d’adolescentes apparait comme asexué renvoyant à un idéal hermaphrodite. Au fur et à mesure des soins, émerge de l’agressivité semblant agir en concomitance avec un processus de féminisation. Nous posons l’hypothèse que cette étape, renvoyant à la neuvième fonction de destruction d’Anzieu (1995) et d’intégration de la fonction tierce, serait essentielle pour accéder à la féminité. À partir d’un cas clinique paradigmatique de notre échantillon de recherche et en appui sur une méthodologie spécifique (Rorschach et entretien clinique), nous allons tenter de mettre en évidence ces différents processus.
Perception des étudiants infirmiers au Liban de l’apprentissage par problème
Authors: Sassine Kazan Rima , Merheb Pauline , Chemali-Hajal Gisèle , Karam-Bader Joêlle
Published: July 2019

Introduction : l’apprentissage par problème (APP) a été introduit dans les programmes universitaires de formation infirmière suite à l’implantation de l’approche par compétences (APC) qui a exigé une réforme pédagogique d’où l’intérêt de cette méthode. L’APP permet de stimuler chez les étudiants des habiletés de pensée critique, identifiées comme le défi prioritaire de la formation infirmière au XXI ème siècle. Contexte : plusieurs études ont été réalisées pour comprendre la perception des étudiants infirmiers de premier cycle quant à l’utilisation de l’APP dans la formation. Les résultats ont mis en relief la présence des aspects positifs et négatifs émanant de cette méthode. Objectif : le but de cet article est de décrire la perception des étudiants infirmiers quant à l’évaluation de l’APP dans leur processus d’apprentissage. Méthode : il s’agit d’une étude qualitative descriptive réalisée auprès de 20 étudiants en sciences infirmières à l’aide d’entrevues individuelles semi-dirigées. Résultats : les résultats issus de l’étude ont regroupé deux grands thèmes qui sont les aspects positifs et négatifs perçus par les étudiants envers l’APP. Les aspects positifs comprennent le développement des relations amicales dans les sous-groupes, le changement comportemental lors de l’apprentissage ainsi que le développement de l’autonomie de l’étudiant. Quant aux aspects négatifs, ils englobent le sentiment d’avoir des connaissances insuffisantes, la difficulté de gestion du temps lors de l’apprentissage et le manque de cohésion dans le groupe. Conclusion : les résultats émanant de cette étude permettraient de développer des stratégies de promotion de l’apprentissage afin d’aider les étudiants à être plus actifs dans leur apprentissage.
The Use of Spatial Analysis Approaches for Smart Decision Making of Subterranean Water
Authors: Kalaitzis Panagiotis , Kavroudakis Dimitris , Soulakellis Nikolaos A.
Published: July 2019

Water is one of life's and nature's most dominant elements, with its presence influencing and controlling the climatic, geological, and biological conditions of an area. Continuous monitoring of subterranean water with the aim of its optimal management has become necessary nowadays. The aspiration of this research is, that the development of “smart” methods for this purpose, will lead to the optimization of the quality of life of the inhabitants of a region, always respecting the environment. The use of geoinformatics methods can contribute to the development of models according to which a network for the logging and control of boreholes and subterranean water will be created, which in turn will lead to smart and direct decision-making concerning their management. In this research, an effort is made to show the contribution of spatial analysis to the design and management of the subterranean water of an area, with the vision of a smart city being the ultimate goal.
Leaf tissue flows and defoliation patterns of Alexandergrass grazed by heifers receiving energy supplement
Authors: Severo Paula De Oliveira , Pötter Luciana , Rocha Marta Gomes da , Negrini Mateus , Martini Amanda Carneiro , Rosa Vanessa Bayer da
Published: July 2019

The study was carried out to evaluate defoliation patterns and to quantify leaf tissue flows in Alexandergrass (Urochloa plantaginea (Link.) Hitch) grazed by beef heifers receiving whole rice bran in three levels of supplementation (0, 0.5 and 1 % of body weight). A rotational stocking grazing method and two area replications were utilized. The experimental design was completely randomized following a repeated measure arrangement. The supply of rice bran to heifers grazing Alexandergrass increased the stocking rate by 13%. Regardless of the feeding system, the heifers grazed the expanding leaf blades in the top stratum of the canopy more frequently compared to other types of leaf. Leaf tissue flows, leaf blade intake and grazing intensity have not been changed by supplement fed.
Banana leaf in the diet of laying hens in cage free system
Authors: Silva Nayara Emanuelle Matos e , Lima Heder José D'Ávila , Valentim Jean Kaique , Tossué Fernandes Jesuino Mukissaí , Bittencourt Tatiana Marques , Velarde Jonatan Mikhail Del Solar
Published: July 2019

The aim of this research was evaluate the productive performance, egg quality and the endoparasites presence on Carijo laying hens in Cage Free system, fed with two experimental diets, one of them supplemented with fresh banana leaf in natura. Were used 196 laying hens with twenty-four weeks of age, distributed in a completely randomized design with 14 boxes, two experimental diets and seven replicates, by treatment with fourteen birds per experimental unit. The variables analyzed were: feed intake; egg production; egg mass: feed conversion per egg mass; feed conversion per dozen eggs; egg weight; albumen weight; yolk weight; shell weight; yolk percentage; albumen percentage shell percentage; yolk pigmentation and the presence of endoparasites. No influence (p > 0.05) were found, for performance and egg production, in Carijo laying hens fed supplemented with banana leaf in natura. For the treatment with inclusion of banana leaf, yolk pigmentation were superior (p < 0.05) when compared to control diet, producing eggs with more yolks orange color. In respect to endoparasite analysis, there was significant effect (p < 0.05) in the percentage of infections present in excretas. Among the treatments evaluated, the one with banana leaf supplementation reduced in 26.54% the endoparasites presence. The inclusion of banana leaf in the diet of Carijo laying hens does not affect performance and eggs quality and decreases the amount of endoparasites of the genus Strogyloides spp.
Assessment of Muscles Fatigue during 400-Meters Running Strategies Based on the Surface EMG Signals
Authors: Yousif Hayder A. , Norasmadi Abdul Rahim , Bin Salleh Ahmad Faizal , Ammar Zakaria , Alfarhan Khudhur A.
Published: July 2019

The aim of this research work is to assess the muscles fatigue of the male runner during 400 meters (m) running with three types of running strategies. The Electromyography (EMG) signals from the Rectus Femoris (RF), Biceps Femoris (BF), Gluteus Maximus (GM), Gastrocnemius Lateralis (GL), and Gastrocnemius Medialis (GMS) were collected by using bipolar electrodes from the right lower extremity’s muscles. EMG signals were collected during the run on the tartan athletic track. Five subjects (non-athletes) had run 400m with three various types of running strategies. The first type: the first 200m running 85-93% of full speed and the last 200m sprinting (full speed), second type: the first 300m running 85-93% of sprinting and the last 100m sprinting, and third type: running 85-93% of sprinting for 400m. The EMG signals were transformed to the time-frequency domain using Short Time Fourier Transform to calculate the instantaneous mean frequency (IMNF) and instantaneous median frequency (IMDF). The less index fatigues were during 1st strategy, while the RF, BF, GM, and GL muscles got recovered with IMNF and IMDF with the three strategies, and the GMS muscle has less negative regression slope value with IMNF with 1st strategy during the 4th 100m of the 400m running event. From the results, it can be concluded the running with the 1st strategy get less fatigues compared with the 2nd and 3rd strategy based on the results of time-frequency domain features (IMNF and IMDF).
Portable and Rapid In Vivo Imaging of Tissue Oxygenation Changes Induced by Skin Perfusion Pressure
Authors: Huong Audrey , Ngu Xavier
Published: July 2019

Current imaging systems available in the study of tissue hemodynamics and vascular reactivity are typically complex and bulky, hence limiting their applications to laboratory use. The aim of this study is to present the dynamics of skin oxygen level with changes in the microcirculatory perfusion monitored using a developed field portable, handheld tri-wavelength imaging system. The skin oxygen saturation level (StO2) was measured in-vivo in a span of 12 minutes in the ventral forearm of seven healthy humans at rest, before and after supra-diastolic and supra-systolic pressure inflations. The findings of this work showed statistical significance in the difference between the mean StO2 values in baseline and that following ischemic episodes with ρ ≤ 0.03. The values returned to baseline, although of different magnitude for each individual, within 2 min (ρ =0.217) during reperfusion could suggest the time required for the resume of normal autoregulation mechanisms and vasomotion reactivities in the recruits. This study concluded that the developed imaging system could find potential application in self-healthcare management and may help to improve patient care in remote or rural locations.
Physiotherapy graduates' contribution to South Africa's health needs - A ten year survey of the University of the Witwatersrand
Authors: Stewart A. , Wallner P. J. , Blecher L. , Bridgeford T. , Kirk J. , Salmon M.
Published: July 2019

Graduates of the University of the Witwatersrand Physiotherapy department were surveyed by means of a questionnaire over a ten-year period, 1980-1990. It was found that almost thirty percent of the graduates were not in any way contributing to the health needs of the country. Twenty percent have left the country and a further nine percent are not practising physiotherapists. Of the remainder, only twenty-six percent are working in the public health sector which serves eighty percent of the population. Their work profiles and job satisfaction are also discussed.
A Rare Case Report of High-Grade Endometrial Stromal Sarcoma in a Seemingly Healthy Uterus of a Young Patient – Optimally Managed by Minimally Access Surgery
Authors: Jain Kanika , Dutta Debasis , Chopra Kanika , Gupta Pallav
Published: July 2019

Endometrial stromal sarcomas (ESSs) are a rare entity, constituting 10% of all uterine sarcomas and 0.2% of all uterine malignancies. We report a very rare case of high-grade endometrial stromal sarcoma in a 34-year-old female with fibroids uterus diagnosed postlaparoscopic hysterectomy. Thereafter, laparoscopic paraaortic and pelvic lymphadenectomy and bilateral oophorectomy were done. The diagnosis of high-grade endometrial stromal sarcoma Stage 1A was made, with lymph nodes and ovaries free from the disease. The patient is undergoing chemoradiotherapy at present and is in a close follow-up with us. ESS should be included as differential diagnosis of abnormal uterine bleeding so that best possible management of the patient can be done.
Acute Pancreatitis Caused by Pemetrexed, Carboplatin, and Gemcitabine in a Patient with Lung Cancer: A Rare Case Report
Authors: Kulkarni Vishal , Srinivasa BJ , Kiran PK , Sarathy Vinu , Swamy S Shivakumar , Naik Radheshyam
Published: July 2019

Drug-induced pancreatitis is reported as one of the less common causes of acute pancreatitis. Many drugs such as sulfonamides, estrogens, tetracyclines, valproic acid, antiretroviral drugs, some chemotherapy drugs such as azathioprine, and 6 MP are known to cause acute pancreatitis. We report a case of acute pancreatitis following administration of chemotherapy for non-small cell lung cancer (NSCLC). The patient was diagnosed to have NSCLC (histologically proven adenocarcinoma). After thorough evaluation including radiological investigations consisting of a positron-emission tomography computed tomography scan, he was staged as a Stage III B NSCLC. As per protocol, he was started on combination chemotherapy with pemetrexed and carboplatin. After 2 weeks of chemotherapy, he developed acute pancreatitis which was managed conservatively. He was administered different drug combination during the next cycle involving gemcitabine and carboplatin. However, he developed recurrent acute pancreatitis which was managed conservatively. He was then referred to the radiotherapy department as it was deemed that he is at risk of recurrent episodes of pancreatitis if further cycles of chemotherapy are continued.
Angiomatous Granuloma Mimicking Verruciform lesion
Authors: Bhayya Harsha , Tejasvi Avinash , Donempudi Pavani , Paramkusam Geetha , Kardalkar Swetha
Published: July 2019

Angiomatous granuloma also called as pyogenic granuloma (PG) is a benign soft-tissue tumor of the skin and mucous membrane arising in response to various stimuli such as local irritation, traumatic injury, or hormonal factors. PGs show a striking predilection for the gingiva. Extragingivally, it can be seen in areas of frequent trauma. It predominantly occurs in the second decade of life and is more common in females than males due to vascular effects of female hormones; here, we present a unique case in a 4-year-old female patient with a gingival growth mimicking a verrucous hyperplasia which is very rare in that age.
Outcomes of Breast Cancer Management from an Urban Specialist Breast Center in South India
Authors: Mullapudi Naga Amulya , Kirti Kabeer Katherine , Padmanaban Naveen , Nimmagadda Ramesh , Radhakrishna Selvi
Published: July 2019

Context and Aims: The disease pattern and presentation of breast cancer in India are thought to differ from the West. The purpose of this study is to describe and to discuss the presentation, clinicopathological data, and survival from an urban specialist breast center in Southern India. Materials and Methods: Prospectively collected data were analyzed for clinicopathological details, treatment variables, and survival outcomes were analyzed. Cumulative survival curves were estimated using the Kaplan–Meier method for patients treated from 2007 to 2011. Results: A total of 1671 patients were operated at our center from January 2007 to December 2016. Average age at diagnosis was 54.2 years. Over 70% had Stage I and Stage II disease, infiltrating duct carcinoma was predominant in 88.2%. Average clinical tumor size was three centimeters. Breast conservation was performed in 22.4%. Sentinel lymph node biopsy was performed in 44.6%. Estrogen-receptor positivity was seen in 64.6%, 22.2% were Her2Neu positive. Triple negative disease was seen in 19.1%. Survival analysis was done using the Kaplan–Meier curves for 540 patients treated from 2007 to 2011. The median follow-up of surviving patients was 70 months with 10% lost to follow-up. In our study population, the 5 years overall survival rate is 88.3% and disease-free survival is 85.7%. Conclusion: Our study reflects a higher percentage of early breast cancer with outcomes comparable to the West. More research is required to understand the genetic predisposition in our population.
Treatment Refusal and Abandonment Remain Major Concerns Despite Good Outcomes with Multi-Modality Management in Pediatric Medulloblastoma: Experience from a Cancer Center in Eastern India
Authors: Das Anirban , Achari Rimpa Basu , Zameer Lateef , Sen Saugata , Krishnan Shekhar , Bhattacharyya Arpita
Published: July 2019

Context: Survival in medulloblastoma, the most common pediatric brain tumor, has lagged behind in developing countries in comparison to the West. Aim: The aim of this study was to analyze the clinical profile and outcome in a cancer center in Eastern India. Methods: Twenty-nine children were retrospectively analyzed over 6 years. Results: Vomiting (79%), headache (69%), and unsteadiness (55%) were the presenting complaints. The majority (67%) had classical histology. High-risk (HR) disease (61.6%) exceeded average-risk (AR) (38.4%) disease in numbers. Treatment-refusal (27.6%) and abandonment (6.9%) were major concerns. Four-year EFS was 81% and 52%, excluding and including refusal/abandonment, respectively. There was no relapse/progression among AR patients. Four-year EFS in HR was 63%. Posterior fossa syndrome (37.5%), febrile neutropenia (29%), and ototoxicity (16.7%) were the main treatment-related morbidities. Implications: Following this audit, patient tracking to reduce abandonment, coordination to limit delay in postsurgical referral, developing strategies for molecular subgrouping, and reducing cumulative cisplatin exposure were measures adopted to improve outcome in the unit.
Bone Marrow Infiltration by Nonhematopoetic Small Round Cell Tumors: A Clinicopathological Study from a Tertiary Care Centre in South India
Authors: Bhopal Triveni , Hussain Abid , Mallikarjun Sai , Lakshmi Sree , Sinha Sudha
Published: July 2019

Objectives: The objective of this study to comprehensively analyze bone marrow (BM) infiltration by nonhematological round cell tumors. Materials and Methods: A total of 206 diagnosed cases of small round blue cell tumors (excluding lymphomas) during a period of 2½ years, referred for BM examination were included in the study. Clinical details were obtained from medical records. BM aspiration (BMA) and BM biopsies (BMBx) were performed under local anesthesia for staging workup. BMBx were studied for cellularity, presence of infiltration by round cells (nonhematopoietic), histologic patterns (island/nests and diffuse sheets), fibrosis, necrosis and other secondary changes. Immunohistochemistry panel was used depending on the morphology. Results: The cases included age range from 45 days to 25 years with a median age of 12 years. There was a male predominance with male:female 1.5:1. Among these, 37/206 cases (17.9%) were positive for BM involvement (BMI) on BMBx. Of these, 24 cases were neuroblastoma (64.8%), 9 cases Ewing’s sarcoma/primitive neuroectodermal tumor (24.3%), and 4 Rhabdomyosarcoma (10.8). BMBx was done in all the 206 cases. Among these, 37/206 cases were positive for BMI on BMBx while 35/206 cases were positive on BM imprints and 33/206 cases were positive on BMA. Conclusion: Detection of metastasis in the BM has both therapeutic and prognostic significance. BMBx are complementary in the diagnosis of small round cell tumor.
A Rare Disease of the Breast: Bowen’s Disease
Authors: Mishra Nabal Kumar , Jain Atul , Patel Gaurav , Nurbhai Sajid Makbul
Published: July 2019

Bowen’s disease is also known as squamous cell carcinoma in situ and it occurs predominantly in older patients. Etiological factors for Bowen’s disease include ultraviolet light mainly, and in some cases, carcinogenic agents such as arsenic coal tar and petroleum products. It is frequently seen in sun-exposed area; however, other unexposed area can also be affected in few patients. Among the unexposed area, this disease affecting breast is a rare entity. These lesions are erythematous with raised, well-defined borders and a scaly appearance that may be confused with psoriasis. They present with an indolent history, having been present for years with slow growth. Histopathologically, there is atypia of the full thickness of the epidermis without dermal invasion. Progression to squamous carcinoma is slow, but 5% ultimately develop dermal invasion. Treatment generally requires complete excision for both definitive diagnosis and to rule out invasion and cure.
Expected Hepatocarcinoma Cancer Rate Due to Escape Mutant among Local Population in Thailand: The Situation after the Implementation of Universal Hepatitis B Vaccination at Birth
Authors: Joob Beuy , Wiwanitkit Viroj
Published: July 2019

Background: Chronic hepatitis B infection is an etiology of hepatocellular carcinoma. The high prevalence of hepatitis B can be seen in several regions including Indochina. In Thailand, a country in Indochina, according to the local public health policies, the universal hepatitis B vaccination is freely given to any infant at birth without charge. Despite the universal vaccination, the hepatitis B seropositive rate is still observed, and it can still be a cause of hepatocellular carcinoma among the hepatitis B carriers in the future. Methods: Here, the authors try to estimate the expected hepatocarcinoma cancer rate due to escape mutant among local population in Thailand, the situation after the implementation of universal hepatitis B vaccination at birth. Results: Based on the present study, the mutant escape contributes to only a few parts of overall estimated cancer cases in the situation that there is an implementation of universal hepatitis B vaccination at birth. Conclusion: Efficacy of theuniversal hepatitis B vaccination is not improved by specific management on escape mutants.
Profile of Pediatric Chronic Myeloid Leukemia in the Era of Imatinib: A Study from South India
Authors: Bernard Catherene , Suman Febe R , Rashmika Rajendran , Latha Magatha Sneha , Scott Julius Xavier , Rajesh V
Published: July 2019

Introduction: Chronic myeloid leukemia (CML), a chronic hematologic malignancy, is rare in pediatric patients. Studies of the tyrosine kinase inhibitor imatinib are required so that uniform guidelines may focus on disease therapy and follow-up for children. We analyzed the clinicohematologic features of the disease, treatment response to imatinib, follow-up measures, and the impact of the disease on the patients and their family. Materials and Methods: All pediatric patients diagnosed with CML and treated and followed-up were studied regarding demographics, clinical features at presentation, and diagnostic profile, including laboratory parameters, peripheral blood smear test, fluorescent in situ hybridization and karyotyping, and reverse-transcriptase polymerase chain reaction for the BCR-ABL fusion gene. Treatment modalities, adverse reactions, remedial measures, assessment at every follow-up visit, patient’s education, parents’ socioeconomic status, and economic and psychological stresses were also evaluated. Results: Six patients were administered upfront therapy with a standard dose of imatinib. Hematological and biochemical parameters were monitored after the drug administration. We assessed the treatment response using molecular detection of the BCR-ABL transcripts. All patients who complied with drug therapy showed a complete molecular response and minimal toxic symptoms. However, parents found it difficult to cope socially and economically. Conclusion: Imatinib mesylate is effective and has a good molecular response, minimal toxicity, and good patient compliance. However, due to its cost, families reacquire financial debt, and the disease creates uncertainty about the child’s future, thereby necessitating psychosocioeconomic support for parents. Changes in the policies of cancer support groups are urgently needed to provide lifelong, lifesaving drugs free of cost.
Metastatic Synovial Sarcoma: Experience from a Tertiary Care Center from India
Authors: Babu K Govind , Patidar Rajesh , Kuntegowdanahalli C Lakshmaiah , Dasappa Lokanatha , Jacob Linu Abraham , Babu Suresh , Rudresha AH , Kadabur Lokesh N , Rajeev LK , Koppaka Deepak , Asati Vikas
Published: July 2019

Background: Synovial sarcoma represents 8% of all soft-tissue sarcoma (STS). It is a high-grade STS, and 50% of patients develop metastasis. The most common site of metastasis is the lungs, lymph nodes followed by bones. Ifosfamide-based chemotherapy is associated with improved outcome. In this study, we report our experience of metastatic synovial sarcoma according to primary sites, metastatic pattern, and their outcome. Materials and Methods: This was a retrospective observational study carried out at our institute from January 2013 to December 2016. The aim of our study was to evaluate the pattern of metastasis, response to chemotherapy, and survival in patients with metastatic synovial sarcoma. Results: Over a period of 4 years, 43 patients with metastatic synovial sarcoma were diagnosed with median age of 30 years. Nearly 70% of patients had lung metastasis, other site of metastasis were lymph node, bone, and liver. Thirty patients received chemotherapy with a combination of ifosfamide and doxorubicin. The overall response rate was 87% with median progression-free survival of 8 months. Patients with lung only metastasis had better survival compared with nonpulmonary metastatic site (18 months vs. 12 months). The median survival was 18 months. Conclusion: Metastatic synovial sarcoma is chemoresponsive tumor with lung being the most common metastatic site. Patients with lung only metastasis had a better outcome than nonpulmonary metastasis.
Isolated Splenic Recurrence of Treated Jejunal Cancer: A Case Report with Brief Review of Literature
Authors: Agrawal Chaturbhuj Ramanand , Sharma Manish , Talwar Vineet , Goel Varun , Singh Ajit Pratap
Published: July 2019

Spleen is a very infrequent site of metastasis despite the fact that it is the most vascular organ in the body. Even if systemic metastasis occurs, splenic metastasis largely remained asymptomatic due to its large functional reserve, and most often, the metastasis is detected incidentally on follow-up scan. Many cases of asymptomatic splenic metastasis detected on follow-up scans are reported in literature from different primary sites. Herein, we report a similar case of a 33-year-old male who presented with isolated splenic recurrence after a long treatment-free interval following curative treatment of adenocarcinoma jejunum. As stated, there are few previous reports of isolated splenic metastasis from carcinoma colon, but considering small intestinal adenocarcinoma, this is the first unique case reported to the best of our knowledge. Due to rarity of clinical scenario and lack of established guidelines, the treatment of such cases varies from patient to patient, and the knowledge, whatever we owe, is on the basis of case reports only.
Pleurodesis in Pulmonary Langerhans Cell Histiocytosis in Children: A Life-Saving Measure
Authors: Prakash Anand , Durugappa Tarangini , Ramachandran Priya , Lalitha AV
Published: July 2019

Isolated pulmonary Langerhans cell histiocytosis (LCH) is uncommon in children. Often recurrent pneumothorax complicates therapy and contributes to morbidity. Chemotherapy does not always prevent the complications of pneumothorax. We report here a young girl with isolated pulmonary LCH who presented with respiratory failure, successfully treated with chemotherapy, and pleurodesis. We report this case to highlight the use of pleurodesis in this setting.
The critical Ising model on amenable graphs of exponential growth
Authors: Raoufi Aran
Published: July 2019

The purpose of this note is to point out that the proof of the recent result of Hutchcroft [Hut] concerning continuity of the phase transition in Bernoulli percolation is applicable to the setting of the Ising model with free boundary conditions. This observation, together with a recent result of Aizenman, Duminil-Copin, and Sidoravicius [ADS] implies that the Ising model on any amenable transitive graph with exponential growth undergoes a continuous phase transition.
Identifying Infectious Diarrhea Hot spots and Associated Socioeconomic Factors in Anhui Province, China
Authors: Hao Yanbin , Zhang Na , Wu Jiabing , Su Bin , Gong Lei , Ma Wanwan , Hou Sai , Zhang Jin , Song Dandan , Liao Wenmin , Zhong Shuang , Yang Lianping , Huang Cunrui
Published: July 2019

Infectious diarrhea cases have increased during the past years in the Anhui Province of China, but little is known about its spatial cluster pattern and associated socioeconomic factors. We obtained county-level total cases of infectious diarrhea in 105 counties of Anhui in 2016 and computed age-adjusted rates. Socioeconomic factors were collected from the Statistical Yearbook. Hot spot analysis was used to identify hot and cold spot counties for infectious diarrhea incidence. We then applied binary logistic regression models to determine the association between socioeconomic factors and hot spot or cold spot clustering risk. Hot spot analysis indicated there were both significant hot spot (29 counties) and cold spot (18 counties) clustering areas for infectious diarrhea in Anhui (P < 0.10). Multivariate binary logistic regression results showed that infectious diarrhea hot spots were positively associated with per capita gross domestic product (GDP), with an adjusted odds ratio (AOR): 3.51, 95% CI: 2.09–5.91, whereas cold spots clustering were positively associated with the number of medical staffs (AOR: 1.18, 95% CI: 1.08–1.29) and negatively associated with the number of public health physicians (AOR: 0.27, 95% CI: 0.09–0.86). We identified locations for hot and cold spot clusters of infectious diarrhea incidence in Anhui, and the clustering risks were significantly associated with health workforce resources and the regional economic development. Targeted interventions should be carried out with considerations of regional socioeconomic conditions.
Treatment Outcomes and Adverse Events from a Standardized Multidrug-Resistant Tuberculosis Regimen in a Rural Setting in Angola
Authors: Aznar María Luisa , Rando Segura Ariadna , Moreno María Milagros , Espasa Mateu , Sulleiro Elena , Bocanegra Cristina , Gil Olivas Eva , Eugénio Arlete Nindia , Zacarias Adriano , Katimba Domingos , Gabriel Estevao , Mendioroz Jacobo , López García Maria Teresa , Pumarola Tomas , Tórtola María Teresa , Molina Israel
Published: July 2019

Treatment for multidrug-resistant tuberculosis (MDR TB) is associated with adverse events (AE). Patients treated with an MDR TB regimen in Hospital Nossa Senhora da Paz, Cubal, Angola, were prospectively enrolled from May 2013 to July 2015. Baseline characteristics, AE, and clinical and microbiological outcomes were recorded. A total of 216 patients were treated with an MDR TB regimen and 179 (82.9%) patients developed at least one AE. The most common AE were elevation of liver enzymes (46.8% of patients), elevated creatinine (44.4% of patients), and ototoxicity (40.7% of patients). Previous TB treatment was associated with the occurrence of AE (OR 4.89, 95% CI: 2.09–11.46, P < 0.001) and months on treatment was associated to severe AE (OR 1.11 95% CI: 1.04–1.18, P = 0.001). Successful treatment was achieved in 117 (54.2%) patients. Incidence of AE was associated with an unsuccessful outcome (OR 1.23, 95% CI: 1.09–1.40, P = 0.001). Patients treated with MDR TB treatment frequently experience AE, and these are related with previous TB treatment and duration of treatment. Given the high percentage of patients experiencing AE and the low treatment success rates, more effective and less toxic drugs to treat MDR TB are urgently needed.
Increased Prevalence of Cestode Infection Associated with History of Deworming among Primary School Children in Ethiopia
Authors: Mohamed Nader , Muse Anna , Wordofa Moges , Abera Dessie , Mesfin Abiyot , Wolde Mistire , Desta Kassu , Tsegaye Aster , Taye Bineyam
Published: July 2019

Mass deworming of school-aged children with anthelmintics has been recognized as an effective approach for reducing the burden of soil-transmitted helminth (STH) infections. However, the consequences of this intervention on nontargeted parasite populations sharing the same gastrointestinal niche are unclear. We conducted a cross-sectional survey among three primary schools in Sululta town, Ethiopia, to examine the association between students’ histories of deworming treatment in the past 6 months and the prevalence of cestode and protozoan infections. An interviewer-led questionnaire administered to parents provided information on sociodemographic factors, and deworming status was ascertained from school records. Stool samples were collected from 525 children for microscopic examination. The independent associations of “any cestode” (positive either for Hymenolepis nana or Taenia spp. eggs) and “any protozoan” (positive either for Giardia lamblia or Entamoeba histolytica/Entamoeba dispar) with history of deworming were examined using logistic regression. Overall, 25.9% of children were infected with at least one intestinal parasite of which H. nana was the most common. In multivariate analyses, deworming in the past 6 months was positively associated with increased odds of both “any protozoan” and “any cestode” infections; the latter reached statistical significance (AOR = 1.83, 95% CI: 0.69–4.86, P = 0.220, AOR = 3.82, 95% CI: 1.17–12.73, P = 0.029, respectively). If this observed association is causal, a greater understanding of interspecies interactions within the gastrointestinal niche may elucidate possible consequences of mass deworming treatments against STHs on coexisting nontargeted parasites.
Análise da concentração produtiva na agropecuária catarinense no período de 1996 a 2016
Authors: Milverstet Matheus Setubal , Fachinello Arlei Luiz
Published: July 2019

A globalização, bem como a modernização das atividades agropecuárias, tem reforçado a sua tendência à especialização produtiva. Em um cenário internacional caracterizado pela grande demanda e valorização de commodities, restrições de mão de obra local, de capital e terra, assim como das exigências institucionais, tornam a possibilidade de o pequeno produtor manter uma produção diversificada cada vez mais difícil. Além disso, políticas públicas que privilegiam determinadas atividades distorcem as decisões de produção reforçando os já presentes ganhos advindas da especialização. Mesmo diante das incertezas nos resultados da produção especializada, a exploração de cultivos que demandam economias de escala parece ser o caminho mais atrativo para um grande número de produtores. Assim, este trabalho visou analisar a existência ou não de uma tendência à concentração produtiva na agropecuária catarinense. Com base no Índice de Herfindahl e no Quociente Locacional, calculados para as últimas duas décadas nas mesorregiões do estado, verificou-se que para Santa Catarina como um todo, os indicadores não apontam tendências a concentração produtiva, mas em algumas de suas mesorregiões há sinais de concentração produtiva.
Características dos processos inovativos do setor industrial do Brasil e da região sul - 2006-2014: análise sob perspectiva teórica neoschumpeteriana
Authors: Eccel Orsi Carolini , Neuberger Daniele , Ferraz Cário Silvio Antonio
Published: July 2019

Este trabalho tem por objetivo apresentar as características dos processos inovativos empreendidos pelas empresas das indústrias extrativas e de transformação do Brasil e dos estados da região sul - Santa Catarina, Paraná e Rio Grande do Sul. Recorre-se aos dados fornecidos pela Pesquisa de Inovação Tecnológica (PINTEC) referentes aos triênios de 2006-2008, 2009-2011 e 2012-2014.Os principais resultados obtidos foram: aquisição de máquinas e equipamentos como atividade inovativa predominante;reduzido esforço em atividade interna de pesquisa e desenvolvimento (P&D); clientes ou consumidores, redes informatizadas e fornecedores listados como principais fontes de informação; clientes ou consumidores e fornecedores apontados como relevantes em atividades de cooperação; reduzidas relações interativas com universidades e institutos de pesquisa e melhoria na qualidade dos produtos e manutenção da participação da empresa no mercado arrolados como principais benefícios obtidos pelo envolvimento em atividades inovativas.
Educação superior e trabalho em Santa Catarina: um enfoque nas carreiras de aplicação direta de ciência e tecnologia
Authors: Custodio Carolina , Bonini Patricia
Published: July 2019

Este artigo apresenta resultados sobre a distribuição espacial e de gênero dos cursos de graduação ligados à ciência e tecnologia em Santa Catarina. Especificamente, enfoca-se na no perfil de gênero dos cursos de formação de aplicação direta de ciência e tecnologia agrupados acrônimo STEM (Science, Technology, Engeneering and Mathematics), tanto em termos de qualificação em nível superior quanto em termos de força de trabalho. A metodologia consiste em análise descritiva de dados primários e secundários sobre ensino universitário e mercado de trabalho. Utilizam-se dados primários de universidades catarinenses e dados secundários do censo universitário do Instituto Nacional de Estudos e Pesquisas Educacionais Anísio Teixeira (INEP), para o ano de 2015, quantificando os cursos de graduação em termos de pessoal entrante e pessoal formado em 2015.
A Skewed perspective of the Indian rainfall-ENSO Relationship
Authors: Schulte Justin , Policielli Fredrick , Zaitchik Benjamin
Published: July 2019

Abstract. The application of higher-order wavelet analysis to India rainfall and the El Niño/Southern Oscillation (ENSO) is presented. An auto-bicoherence analysis is used to extract the frequency modes contributing to the skewness of India rainfall and ENSO. A nonlinear wavelet coherence method is proposed for diagnosing why the time-domain correlation between two time series temporally changes when at least one time series has changing nonlinear characteristics. The results indicate the India rainfall and ENSO are highly nonlinear phenomenon. It is also demonstrated that the sea surface temperature (SST) patterns associated with different nonlinear ENSO modes depend on the frequency components participating in the nonlinear phase coupling. The SST pattern associated with coupling between ENSO modes with periods of 31 and 15.5 months is reminiscent of a central Pacific El Niño and intensifies around 1995, contrasting with the coupling between the 62- and 31-month modes that became active around the 1970s ENSO regime shift. A nonlinear coherence analysis showed that the skewness of India rainfall is weakly correlated with that of 4 ENSO time series after the 1970s, indicating that increases in ENSO skewness after 1970's at least partially contributed to the weakening India rainfall-ENSO relationship in recent decades. The implication of this result is that the intensity of skewed El Niño events is likely to overestimate India drought severity, which was the case in the 1997 monsoon season, a time point when the nonlinear wavelet coherence between All-India rainfall and ENSO reached its lowest value in the 1871–2016 period.