bluuebunny/crossref_metadata_2025 huggingface dataset:
Prognostic significance of negative lymph node count in microsatellite instability-high colorectal cancer
Authors: Dai Xuan , Dai Zhujiang , Fu Jihong , Liang Zhonglin , Du Peng , Wu Tingyu
Published: July 2024

Background

Microsatellite instability-high (MSI-H) tumors, with elevated tumor mutational burden and expression of neoantigens, represent a distinct immune-activated subpopulation in colorectal cancer (CRC), characterized by strong lymph node reaction, locally advanced tumor and higher total lymph nodes harvested (TLN), but less metastatic lymph nodes and fewer incidence of III-IV stage. Host immune response to tumor and lymph nodes may be an important prognostic factor. However, N stage and LNR (Lymph-Node Ratio) have limitations in predicting the prognosis of MSI-H patients. Negative lymph node count (NLC) provided a more precise representation of immune activation status and extent of tumor metastasis. The study aims to detect prognostic significance of NLC in MSI-H CRC patients, and compare it with N stage, TLN and LNR.

Methods

Retrospective data of 190 consecutive MSI-H CRC patients who received curative resection were collected. Survival analyses were performed using the Kaplan–Meier method. Clinicopathological variables including NLC, N stage, TLN and LNR were studied in univariate and multivariate COX regression analyses. ROC (receiver operating characteristic curve) and concordance index were employed to compare the differences in predictive efficacy between NLC, N stage, TLN and LNR.

Results

Patients with increased NLC experienced a significantly improved 5-years DFS and OS in Kaplan–Meier analysis, univariate analysis, and multivariate analysis, independent of potential confounders examined. Increased NLC corresponded to elevated 5-years DFS rate and 5-years OS rate. AUC (area under curve) and concordance index of NLC in DFS and OS predicting were both significantly higher than N stage, TLN and LNR.

Conclusions

Negative lymph node is an important independent prognostic factor for MSI-H patients. Reduced NLC is associated with tumor recurrence and poor survival, which is a stronger prognostic factor than N stage, TLN and LNR.
17β-estradiol in colorectal cancer: friend or foe?
Authors: Wu Zihong , Xiao Chong , Wang Jiamei , Zhou Min , You Fengming , Li Xueke
Published: July 2024

Colorectal cancer (CRC) is a common gastrointestinal malignancy with higher incidence and mortality rates in men compared to women, potentially due to the effects of estrogen signaling. There is substantial evidence supporting the significant role of 17β-Estradiol (E2) in reducing CRC risk in females, although this perspective remains debated. E2 has been demonstrated to inhibit CRC cell proliferation and migration at the cellular level by enhancing DNA mismatch repair, modulating key gene expression, triggering cell cycle arrest, and reducing activity of migration factors. Furthermore, E2 contributes to promote a tumor microenvironment unfavorable for CRC growth by stimulating ERβ expression, reducing inflammatory responses, reversing immunosuppression, and altering the gut microbiome composition. Conversely, under conditions of high oxidative stress, hypoxia, and nutritional deficiencies, E2 may facilitate CRC development through GPER-mediated non-genomic signaling. E2’s influence on CRC involves the genomic and non-genomic signals mediated by ERβ and GPER, respectively, leading to its dual roles in anticancer activity and carcinogenesis. This review aims to summarize the potential mechanisms by which E2 directly or indirectly impacts CRC development, providing insights into the phenomenon of sexual dimorphism in CRC and suggesting potential strategies for prevention and treatment.

Graphical Abstract
Lipid-based nanosystems: the next generation of cancer immune therapy
Authors: Cheng Ziyun , Fobian Seth-Frerich , Gurrieri Elena , Amin Mohamadreza , D’Agostino Vito Giuseppe , Falahati Mojtaba , Zalba Sara , Debets Reno , Garrido María J. , Saeed Mesha , Seynhaeve Ann L. B. , Balcioglu Hayri E. , ten Hagen Timo L. M.
Published: July 2024

Immunotherapy has become an important part of the oncotherapy arsenal. Its applicability in various cancer types is impressive, as well as its use of endogenous mechanisms to achieve desired ends. However, off-target or on-target-off-tumor toxicity, limited activity, lack of control in combination treatments and, especially for solid tumors, low local accumulation, have collectively limited clinical use thereof. These limitations are partially alleviated by delivery systems. Lipid-based nanoparticles (NPs) have emerged as revolutionary carriers due to favorable physicochemical characteristics, with specific applications and strengths particularly useful in immunotherapeutic agent delivery. The aim of this review is to highlight the challenges faced by immunotherapy and how lipid-based NPs have been, and may be further utilized to address such challenges. We discuss recent fundamental and clinical applications of NPs in a range of areas and provide a detailed discussion of the main obstacles in immune checkpoint inhibition therapies, adoptive cellular therapies, and cytokine therapies. We highlight how lipid-based nanosystems could address these through either delivery, direct modulation of the immune system, or targeting of the immunosuppressive tumor microenvironment. We explore advanced and emerging liposomal and lipid nanoparticle (LNP) systems for nucleic acid delivery, intrinsic and extrinsic stimulus-responsive formulations, and biomimetic lipid-based nanosystems in immunotherapy. Finally, we discuss the key challenges relating to the clinical use of lipid-based NP immunotherapies, suggesting future research directions for the near term to realize the potential of these innovative lipid-based nanosystems, as they become the crucial steppingstone towards the necessary enhancement of the efficacy of immunotherapy.

Graphical abstract
Unveiling the influence of hip isokinetic strength on lower extremity running kinematics in male national middle-distance runners: a correlational analysis
Authors: Sever Ozan , Öztaşyonar Yunus , Ceylan Halil İbrahim , Miçooğullari Bülent Okan , Morgans Ryland , Bragazzi Nicola Luigi
Published: July 2024

Background

The relationship between hip strength deficiency in various planes and musculoskeletal injuries within the movement system has been well-established in numerous studies. The present study sought to explore the relationships between hip strength and specific aspects of lower extremity running kinematics.

Methodology

To achieve this objective, the three-dimensional running kinematics of 21 male elite middle-distance runners (mean age: 19.7 ± 1.2 years; mean experience 6.5 ± 1.0 years) were assessed using nine high-speed cameras on a treadmill at a speed of 16 km·h⁻¹. Concurrently, isokinetic hip strength was measured at a speed of 60 deg·s⁻¹ in both the dominant and non-dominant legs. The Pearson correlation coefficient and Paired Samples t-test were utilized.

Results

While no significant differences were found in several isokinetic strength measurements, notable differences in running kinematics were observed. Specifically, pelvic drop at midstance (MS) was significantly lower in the DL (5.79 ± 3.00°) compared to the NDL (8.71 ± 1.39°) with a large effect size (t=-4.04, p < 0.001, Cohen’s d = 1.25). Additionally, knee adduction at maximum showed a moderate effect size difference, with the DL at 2.99 ± 1.13° and the NDL at 3.81 ± 1.76° (t=-2.74, p = 0.03, Cohen’s d = 0.55). Results indicated a moderate to highly positive association between running knee adduction in the dominant leg and hip external rotation (r = 0.67, p < 0.05), concentric extension (r = 0.77, p < 0.05), and concentric abduction (r = 0.78, p < 0.05). Additionally, the running tibial external rotation angle in the dominant leg exhibited an inverse relationship with all strength measurements, with statistical significance observed only for concentric extension force (r=-0.68, p < 0.05). Furthermore, hip internal rotation force demonstrated a highly inverse correlation with foot pronation in the dominant leg (r=-0.70, p < 0.05) and anterior pelvic tilt in the non-dominant leg (r=-0.76, p < 0.05).

Conclusions

These findings underscore the interrelation between hip strength and running kinematics, particularly on the dominant side. In light of these observations, it is imperative to consider hip strength exercises as integral components for correcting running kinematics. Coaches should also be mindful that kinematic deviations contributing to running injuries may manifest unilaterally or specifically in the dominant leg.
Reaction rebalancing: a novel approach to curating reaction databases
Authors: Phan Tieu-Long , Weinbauer Klaus , Gärtner Thomas , Merkle Daniel , Andersen Jakob L. , Fagerberg Rolf , Stadler Peter F.
Published: July 2024

Purpose

Reaction databases are a key resource for a wide variety of applications in computational chemistry and biochemistry, including Computer-aided Synthesis Planning (CASP) and the large-scale analysis of metabolic networks. The full potential of these resources can only be realized if datasets are accurate and complete. Missing co-reactants and co-products, i.e., unbalanced reactions, however, are the rule rather than the exception. The curation and correction of such incomplete entries is thus an urgent need.

Methods

The framework addresses this issue with a dual-strategy: a rule-based method for non-carbon compounds, using atomic symbols and counts for prediction, alongside a Maximum Common Subgraph (MCS)-based technique for carbon compounds, aimed at aligning reactants and products to infer missing entities.

Results

The rule-based method exceeded 99% accuracy, while MCS-based accuracy varied from 81.19 to 99.33%, depending on reaction properties. Furthermore, an applicability domain and a machine learning scoring function were devised to quantify prediction confidence. The overall efficacy of this framework was delineated through its success rate and accuracy metrics, which spanned from 89.83 to 99.75% and 90.85 to 99.05%, respectively.

Conclusion

The framework offers a novel solution for recalibrating chemical reactions, significantly enhancing reaction completeness. With rigorous validation, it achieved groundbreaking accuracy in reaction rebalancing. This sets the stage for future improvement in particular of atom-atom mapping techniques as well as of downstream tasks such as automated synthesis planning.

Scientific Contribution

features a novel computational approach to correcting unbalanced entries in chemical reaction databases. By combining heuristic rules for inferring non-carbon compounds and common subgraph searches to address carbon unbalance, successfully addresses most instances of this problem, which affects the majority of data in most large-scale resources. Compared to alternative solutions, achieves a dramatic increase in both success rate and accurary, and provides the first freely available open source solution for this problem.
Artificial intelligence-based joint attenuation and scatter correction strategies for multi-tracer total-body PET
Authors: Sun Hao , Huang Yanchao , Hu Debin , Hong Xiaotong , Salimi Yazdan , Lv Wenbing , Chen Hongwen , Zaidi Habib , Wu Hubing , Lu Lijun
Published: July 2024

Background

Low-dose ungated CT is commonly used for total-body PET attenuation and scatter correction (ASC). However, CT-based ASC (CT-ASC) is limited by radiation dose risks of CT examinations, propagation of CT-based artifacts and potential mismatches between PET and CT. We demonstrate the feasibility of direct ASC for multi-tracer total-body PET in the image domain.

Methods

Clinical uEXPLORER total-body PET/CT datasets of [18F]FDG (N = 52), [18F]FAPI (N = 46) and [68Ga]FAPI (N = 60) were retrospectively enrolled in this study. We developed an improved 3D conditional generative adversarial network (cGAN) to directly estimate attenuation and scatter-corrected PET images from non-attenuation and scatter-corrected (NASC) PET images. The feasibility of the proposed 3D cGAN-based ASC was validated using four training strategies: (1) Paired 3D NASC and CT-ASC PET images from three tracers were pooled into one centralized server (CZ-ASC). (2) Paired 3D NASC and CT-ASC PET images from each tracer were individually used (DL-ASC). (3) Paired NASC and CT-ASC PET images from one tracer ([18F]FDG) were used to train the networks, while the other two tracers were used for testing without fine-tuning (NFT-ASC). (4) The pre-trained networks of (3) were fine-tuned with two other tracers individually (FT-ASC). We trained all networks in fivefold cross-validation. The performance of all ASC methods was evaluated by qualitative and quantitative metrics using CT-ASC as the reference.

Results

CZ-ASC, DL-ASC and FT-ASC showed comparable visual quality with CT-ASC for all tracers. CZ-ASC and DL-ASC resulted in a normalized mean absolute error (NMAE) of 8.51 ± 7.32% versus 7.36 ± 6.77% (p < 0.05), outperforming NASC (p < 0.0001) in [18F]FDG dataset. CZ-ASC, FT-ASC and DL-ASC led to NMAE of 6.44 ± 7.02%, 6.55 ± 5.89%, and 7.25 ± 6.33% in [18F]FAPI dataset, and NMAE of 5.53 ± 3.99%, 5.60 ± 4.02%, and 5.68 ± 4.12% in [68Ga]FAPI dataset, respectively. CZ-ASC, FT-ASC and DL-ASC were superior to NASC (p < 0.0001) and NFT-ASC (p < 0.0001) in terms of NMAE results.

Conclusions

CZ-ASC, DL-ASC and FT-ASC demonstrated the feasibility of providing accurate and robust ASC for multi-tracer total-body PET, thereby reducing the radiation hazards to patients from redundant CT examinations. CZ-ASC and FT-ASC could outperform DL-ASC for cross-tracer total-body PET AC.
Multiple foci of Rosai–Dorfman disease in colon: a case report
Authors: Kisu Eri , Hiraki Masatsugu , Okuyama Keiichiro , Maeda Sachiko , Takesue Shin , Kusaba Kana , Kai Keita , Manabe Tatsuya , Noshiro Hirokazu
Published: July 2024

Background

Rosai–Dorfman disease (RDD) is an uncommon proliferative histiocytic disorder involving lymph nodes and various organs. Forty-three percent of RDD cases originate from extranodal sites; however, RDD rarely arises from the colon.

Case presentation

A 75-year-old man was admitted to our hospital because of intra-abdominal masses that were incidentally detected during surveillance by computed tomography (CT) after treatment for lung cancer. Enhanced CT showed two mass lesions located in the cecum to the appendix (diameter, 40 mm) and around the sigmoid colon (diameter, 24 mm). Positron emission tomography (PET)-CT revealed an apparent uptake of fluorodeoxyglucose. Intraluminal endoscopy did not reveal definite mucosal abnormalities. These findings suggest the presence of malignant neoplasms including gastrointestinal stromal tumors, lung cancer metastasis, and malignant lymphoma. Exploratory laparoscopy and/or tumor excision were planned to obtain a definitive diagnosis. Based on laparoscopic findings, ileocecal resection and sigmoidectomy were simultaneously performed to excise the tumors. Postoperative histopathological examination revealed multiple RDD originating from the mesocolon side of the cecum and the sigmoid colon. The patient did not receive any adjuvant therapy. No recurrence was observed one year after surgery.

Conclusion

RDD originating from the colon is extremely rare. Tumor extirpation or organ resection is sometimes required to obtain a definitive diagnosis of RDD, and minimally invasive surgery is helpful.
Interplay of Muscle Architecture, Morphology, and Quality in Influencing Human Sprint Cycling Performance: A Systematic Review
Authors: Martin-Rodriguez Saul , Gonzalez-Henriquez Juan J. , Bautista Iker J. , Calbet Jose A. L. , Sanchis-Moysi Joaquin
Published: July 2024

Background

This systematic review aimed to discern the relationships between muscle morphology, architecture, and quality with sprint cycling performance while considering the multifaceted nature of these relationships across diverse studies.

Methods

Employing the PRISMA guidelines, an exhaustive search was performed across four primary databases: MEDLINE/PubMed, Web of Science, CINAHL Complete, and SPORTDiscus. The Methodological Index For Non-Randomised Studies (MINORS) was used to assess the methodological quality of the included studies. Out of 3971 initially identified records, only 10 studies met the eligibility criteria.

Results

These investigations underscored the robust relationship of quadriceps muscle volume with peak power output (R2 from 0.65 to 0.82), suggesting its pivotal role in force production. In muscle architecture, the pennation angle and fascicle length showed varied associations with performance. Furthermore, muscle quality, as denoted by echo intensity, showed preliminary evidence of a potential inverse relationship with performance. The methodological quality assessment revealed varied scores, with the most consistent reporting on the aim, endpoints, and inclusion of consecutive patients. However, limitations were observed in the prospective calculation of study size and unbiased assessment of study endpoints.

Conclusion

Our findings indicate that muscle volume is a major determinant of sprint cycling performance. Muscle architecture and quality also impact performance, although in a more intricate way. The review calls for standardised methodologies in future research for a more comprehensive understanding and comparability of results.

PROSPERO registration number

CRD42023432824 (https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=432824).
Surrealism’s “Primitive Reason”: Magic, Technique, Alteration
Authors: Cheng Joyce
Published: July 2024

This essay examines the primitivist art theories of the surrealist milieu, focusing on the concept of magic. The first part shows how, informed by early twentieth-century ethnological theories, the surrealist poets like André Breton, Louis Aragon, and Jules Monnerot evoked magic to name a creative method that circumvents artistic originality and the means-and-end logic of technique. This generalization of magic as aesthetic concept contributed to surrealism’s ethical-political project in the early 1930s, which positioned itself against a bourgeois art complicit with European imperialism and solidarized with cultures the former deemed “magical” or “primitive.” The second part shows how the concurrent art theories of George Bataille and Carl Einstein participated in the surrealists’ project of the “universal primitive,” but maintained the primitive-modern dichotomy in their affirmation of comparable oppositions: for instance, barbarian transgression versus civilized ideality (Bataille), or manual artisanry versus mechanization (Einstein). Finally, I suggest that the surrealists circumvent this predicament when considering the mechanical medium of photography as magic, thereby reconstruing the condition of demanualization (the dispensability of the human hand in making) as primitive and modern.
“We Are All Endangered Species”: Jerome Rothenberg’s Jewish Primitivism
Authors: Spinner Samuel J.
Published: July 2024

Jerome Rothenberg’s poetry brings together a group of major—seemingly disparate—topics: the Holocaust; ecological crisis; Yiddish culture; and what he terms ethnopoetics, a poetic primitivism centered largely on the culture of Indigenous Americans. This article shows how genocide, both of Native Americans and of European Jews, becomes in Rothenberg’s poetry the catalyst for a new purpose for primitivism—resisting ecological and cultural devastation. Rothenberg’s reactivation of Jewish primitivism follows two paths: first, an insistence on understanding the destruction of Jewish culture in conjunction with the destruction of Indigenous peoples and cultures globally. Second, he links these genocides to the scope and consequences of environmental destruction, which he recognizes as an integral part of the threat to minority cultures and to humanity in general. Rothenberg’s primitivist poetry seeks to resist extinction. This is a striking attempt to negate the association of primitivism with colonial domination and violence and create a poetry of survival in the face of genocide and environmental destruction.
Ensino do direito do trabalho em escolas de administração por meio de casos rápidos (quick cases): auxiliando a tomada de decisão
Authors: Cavalcanti Boucinhas Filho Jorge
Published: July 2024

Objetivo: O objetivo deste texto é discutir a metodologia mais adequada para o ensino de Direito do Trabalho nas Escolas de Administração de Empresas, nas quais ela é uma disciplina propedêutica.
Escopo: O escopo do trabalho é compartilhar experiências bem sucedidas com a utilização de quick cases que preparem o futuro administrador para tomar decisões acertadas em relação à contratação de mão de obra, gestão de pessoas e prevenção de litígios trabalhistas.
Originalidade: A originalidade do texto está na possibilidade de engajar os alunos e cobrir todo o conteúdo da disciplina a partir da resolução e debate sobre quick cases, fictícios ou inspirados em situações reais.
Relevância: O tema é relevante na medida em que a utilização de metodologia idêntica à que é utilizada nas faculdades de Direito pouco contribui para a futura atuação profissional dos estudantes e pode não gerar engajamento.
Espera-se que a vivência compartilhada possa inspirar outros docentes na preparação de suas aulas, ofertando-lhes mais uma possibilidade planejá-las.
Aprendendo com os governos subnacionais brasileiros: dez anos de imersão local
Authors: Burgos Fernando , Cavaller Guzzi André , Bresciani Luís Paulo , Franzese Cibele , Lemos Sandim Tatiana
Published: July 2024

Objetivo: Apresentar as principais características e transformações da disciplina obrigatória Imersão Local do curso de graduação em Administração Pública da Escola de Administração de Empresas de São Paulo da Fundação Getulio Vargas (FGV EAESP), uma prática de ensino inovadora que está completando dez anos em 2024.
Escopo: Essa disciplina única tem como objetivo fazer com que os alunos e alunas aprendam com as experiências de contato direto com os governos municipais ou estaduais, além de elaborar e propor soluções para problemas reais enfrentados pelos órgãos visitados. Essas soluções são apresentadas aos gestores públicos no fim do semestre. Ao longo dos dez anos de sua existência, aproximadamente 900 estudantes visitaram 89 cidades em quase todos os estados brasileiros.
Originalidade: A disciplina Imersão Local se destaca por proporcionar uma experiência de aprendizagem inovadora, onde os estudantes têm a oportunidade de trabalhar diretamente com gestores públicos e enfrentar problemas reais da gestão pública brasileira.
Relevância: A disciplina de Imersão local proporciona uma compreensão prática e aplicada da gestão pública, preparando melhor os alunos para enfrentarem os desafios do setor público no Brasil. A análise da disciplina mostra as mudanças em seu desenho ao longo do tempo, bem como os desafios metodológicos, pedagógicos e operacionais para implementar de maneira efetiva essa experiência.
Inovação pedagógica e os desafios do tempo presente
Authors: Campana Carla
Published: July 2024

Objetivo: Este texto propõe reflexões sobre inovação pedagógica ao articular desafios contemporâneos com a necessidade de repensar as estratégias educacionais.
Escopo: Explora o conceito de inovação, analisa a interseção entre inovações tecnológicas e sociais no ensino, destacando a importância da interação humana para a aprendizagem significativa; explora a necessidade de distinguir entre a aquisição de conhecimento e o desenvolvimento pessoal e social na educação; e aborda o papel compartilhado entre docentes e estudantes na construção do conhecimento.
Originalidade: Propõe diferenciar o papel da inovação na aquisição de novos conhecimentos e no desenvolvimento pessoal e social resultante de um processo educativo intencional, evidenciando o espaço para as inovações de cunho tecnológico, mas também para as de cunho relacional, que rumam na contramão da tendência da virtualidade.
Relevância: Evidencia como a reflexão sobre a inovação pedagógica pode contribuir para mitigar ou agravar os desafios do tempo presente.
Λεπτά υμένια διοξειδίου του κασσίτερου ως διαφανές αγώγιμο οξείδιο για διάφορες οπτοηλεκτρονικές εφαρμογές
Authors: Πεταρούδης Χρήστος
Published: July 2024

Με την έλευση της νανοτεχνολογίας, η σύνθεση νανοδομημένων υλικών όπως είναι τα διαφανή αγώγιμα οξείδια (Transparent Conductive Oxides - TCO) και η τροποποίηση της ηλεκτρονικής δομής τους απέκτησαν μεγάλη σημασία, κυρίως λόγω των χρήσιμων εφαρμογών τους σε ηλεκτρονικές και οπτοηλεκτρονικές διατάξεις. Πράγματι, οι εξαιρετικά χρήσιμες εφαρμογές τους, όπως οι επίπεδες οθόνες, τα φωτοβολταϊκά κύτταρα, οι αισθητήρες αερίων και οι δίοδοι εκπομπής φωτός, έχουν ήδη αρχίσει να γίνονται ιδιαίτερα σημαντικές. Η ποικιλομορφία των υλικών που είναι ενσωματωμένα σε αυτές τις συσκευές, στα οποία συμπεριλαμβάνονται και οι ημιαγωγοί, έχουν κάνει επιτακτική την ανάγκη για υλικά TCO με νέα απόδοση, μορφολογία αλλά και δυνατότητα επεξεργασίας σε χαμηλές ωστόσο θερμοκρασίες. Μεταξύ των υλικών που παρουσιάζουν ιδιαίτερο ενδιαφέρον είναι και τα ημιαγώγιμα υλικά οξειδίων, όπως το οξείδιο του κασσίτερου, που είναι γνωστά για δεκαετίες ως ημιαγωγοί ευρέως ενεργειακού χάσματος (~3eV). Για την εμφάνιση ωστόσο των διαφανών αγώγιμων ιδιοτήτων των ημιαγώγιμων αυτών υλικών, απαραίτητη προϋπόθεση είναι η κατασκευή τους στις σωστές συνθήκες καθώς και η προσθήκη σε αυτά των κατάλληλων υλικών πρόσμιξης.Αντικείμενο της παρούσας Διδακτορικής Διατριβής είναι η κατασκευή διάφανων και ταυτόχρονα αγώγιμων λεπτών υμενίων διοξειδίου του κασσίτερου με χρήση χημικής εναπόθεσης ατμών σε ατμοσφαιρική πίεση (ΑΠΧΕΑ) και η διερεύνηση του ρόλου των προσμίξεων και των συνθηκών εναπόθεσης στις οπτικές και ηλεκτρικές ιδιότητες αυτών των λεπτών υμενίων.Αρχικά, διερευνάται σε βάθος η εναπόθεση των οξειδίων του κασσίτερου σε διαφορετικές συνθήκες όπως πχ σε διαφορετικές θερμοκρασίες υποστρώματος, σε διαφορετικά υποστρώματα, αλλά και με διαφορετικές ροές αερίων, με στόχο την κατανόηση των παραμέτρων που καθορίζουν τη στοιχειομετρία και τις ιδιότητες των οξειδίων. Το περιβάλλον της εναπόθεσης θεωρείται κρίσιμο για τον καθορισμό των ιδιοτήτων των οξειδίων. ‘Έπειτα από τον χαρακτηρισμό του συστήματος λαμβάνουμε τα πρώτα αποτελέσματα σχετικά με τη μεταβολή του πάχους των υμενίων διοξειδίου του κασσίτερου με οξειδωτικό μέσο τους υδρατμούς αλλά και τους ατμούς μεθανόλης, την επίδραση της θερμοκρασίας στη δομή των λεπτών υμενίων καθώς και τις οπτικές τους ιδιότητες. Στη συνέχεια, κάνουμε ταυτόχρονες μετρήσεις ελλειψομετρίας (SE) και ρεύματος-τάσης (I-V) σε ατμοσφαιρικό περιβάλλον σε δυο θερμικούς κύκλους έως και τους 400oC σε υμένια ΑΠΧΕΑ SnO2 τα οποία έχουμε προηγουμένως εναποθέσει υπό παρόμοιες συνθήκες χρησιμοποιώντας στα μεν ατμούς νερού και στα δε ατμούς μεθανόλης ως οξειδωτικά.Κατόπιν γίνεται η μελέτη της μορφολογίας, της δομής και της σύστασης των υμενίων ΑΠΧΕΑ SnO2 κάνοντας ταυτόχρονα και μια σύγκριση στα αποτελέσματα που λαμβάνονται μέσω των διαφόρων μεθόδων χαρακτηρισμού που υφίστανται. Επιπλέον μελετώνται οι οπτικές ιδιότητες των λεπτών υμενίων ΑΠΧΕΑ SnO2 και διερευνάται η εξάρτηση τους από τη θερμοκρασία καθώς επίσης γίνεται μελέτη των ηλεκτρικών ιδιοτήτων τους μέσω ανάλυσης της ηλεκτρονικής δομής τους.
FEATURES OF MENTORING THE HEAD OF THE INVESTIGATIVE BODY OVER THE ACTIVITIES OF THE INVESTIGATOR IN PRE-TRIAL CRIMINAL PROCEEDINGS
Authors: Gorach Nikolay , Makarenko Madina , Moskovtseva Kristina
Published: July 2024

In the modern world, the success of any team, its cohesion and organization largely depends on several factors: competent leadership and integration of the accumulated experience of the mentoring institute. Internal affairs agencies are no exception. Today, a young employee is required not only to have professional qualities and knowledge of the law, but also to be able to quickly adapt to environmental conditions, develop stress tolerance, and constantly improve himself. A mentor helps to overcome most of the difficulties on the way to becoming a future professional in many ways. The subject of this article is the norms of criminal procedure legislation, prescriptions of subordinate normative legal acts that regulate relations in the field of implementation and interaction of procedural control of the head of the investigative body and pedagogical mentoring, law enforcement practice in this area, the works of other scientists on this topic, statistical data, as well as the results of previously conducted sociological research. The purpose of this study is to develop theoretical provisions and recommendations concerning the implementation of procedural control by the head of the investigative body over the activities of the investigator, aimed at the professional development of the investigator's personality, rapid integration into the departmental environment, adaptation and improvement of the necessary professional qualities.
EXPERIENCE OF PEDAGOGICAL PREVENTION OF ASOCIAL BEHAVIOR IN MINORS AT THE CURRENT STAGE
Authors: Sklyarenko Inna , Kupavtsev Timofey , Zyablova Anastasiya
Published: July 2024

The study is devoted to the analysis of the experience of pedagogical prevention of antisocial behavior of minors at the present stage. The reasons underlying this behavior are highlighted. The purpose of the work is a theoretical analysis and assessment of the effectiveness of existing approaches, content and tools of pedagogical prevention, with an emphasis on the axiological approach. An analysis of legal documents, theoretical studies, and examples of modern pedagogical experience is provided in order to study measures to combat and prevent antisocial behavior among minors. The author's position on the concept of pedagogical prevention of antisocial behavior of minors is presented on the basis of an axiological approach, when it is a complex activity of parents, teaching staff, police officers performing pedagogical functions, aimed at developing value attitudes in minors. The authors consider the concept of the value system of minors in the prevention of antisocial behavior and the content and instrumental components in its formation. The value setting of a minor is revealed as a state of his readiness for prosocial behavior, a predisposition for personal development in various spheres of life, and is a significant characteristic of the individual.
Losy staropolskich ksiąg miejskich Sandomierza w XIX i XX wieku
Authors: Burdzy-Jeżewska Dominika
Published: July 2024

The text covers the history of Sandomierz town records from the modern period. In the 19th and 20th centuries, town books were incomplete and scattered in the resources of several institutions: the Central Archives of Historical Records in Warsaw, the Krasiński Ordinance Library in Warsaw, the Archives of the Cathedral Chapter in Sandomierz, the Sandomierz municipal office. In the interwar period, the town authorities of Sandomierz together with historians and regionalists, undertook to recover some of these books by purchasing them from private hands. The destruction caused by two world wars, especially the deliberate destruction of Warsaw archives and libraries after the 1944 uprising, had a huge impact on the state of preservation of city books (including Sandomierz town books). Currently, this archival group of records includes the books of the town council, the town bench, tax and accounting books and is divided between two archives: the State Archives in Kielce, Branch in Sandomierz and the Archive of the Sandomierz Cathedral Chapter.
Perancangan Sistem Informasi Geografis berbasis Web untuk Pembuatan Objek Wisata Waduk Selorejo dengan QuantumGIS
Authors: Aditya Farhan Qashidi , Yuwono Yuwono
Published: July 2024

Waduk Selorejo secara administratif berada pada Kabupaten Malang dan tepatnya berada pada Desa Pandansari, Kecamatan Ngantang. Waduk Selorejo menjadi salah satu destinasi wisata yang cukup  terkenal di Jawa Timur. Waduk Selorejo merupakan kawasan wisata yang memiliki banyak  potensi yang dapat dikembangkan. Sistem Informasi Geografis merupakan sistem informasi  berbasis komputer yang digunakan untuk mengolah dan menyimpan data atau informasi geografis. Sistem Informasi Geografis berbasis Web merupakan sistem informasi geografis yang didistribusikan diseluruh lingkungan jaringan komputer untuk mengintegrasikan, menyebarkan, dan mengkomunikasikan informasi geografis secara visual di World Wide Web melalui internet. Quantum GIS (QGIS) adalah perangkat lunak desktop pada Sistem Informas Geografis yang memiliki fungsi yaitu menyediakan data, melihat, mengedit, dan memiliki kemampuan analisis spasial. Dengan menggunakan data potensi wisata Waduk Selorejo yang dimasukan kedalam perangkat lunak QGIS. Hasil penelitian ini diharapkan dapat meningkatkan kunjungan wisatawan yang dapat dijadikan acuan oleh instansi terkait dalam melaksanakan pengembangan potensi wisata Waduk Selorejo.
Analisis Pemodelan Tiga Dimensi Candi Tikus Menggunakan Fotogrametri Jarak Dekat
Authors: Jardini Agdya Rifananda , Hariyanto Teguh
Published: July 2024

Candi Tikus merupakan satu-satunya warisan bangunan cagar budaya berupa candi sekaligus petirtaan yang ada di situs Trowulan dan termasuk kedalam kerajaan Hindu-Budha terbesar di Indonesia yaitu Kerajaan Majapahit. Oleh karena itu, Candi Tikus ini harus dilestarikan dengan cara dirawat dan dipelihara keberadaannya. Salah satu cara untuk mempertahankan keberadaannya adalah dengan cara pendokumentasian. Kegiatan pendokumentasian yang dapat dilakukan untuk melihat secara detail bentuk bangunan adalah melakukan pemodelan 3 dimensi (3D) dengan fotogrametri jarak dekat atau biasa dikenal dengan close range photogrammetry. Akuisisi data dilakukan di lapangan menggunakan wahana UAV dengan perolehan berupa foto udara sebanyak 146 foto dan kamera DSLR dengan perolehan berupa foto terestrial sebanyak 357 foto. Hasil akuisisi data kemudian diolah untuk mendapatkan hasil berupa rekonstruksi 3D model yang kemudian dianalisis akurasi geometriknya menggunakan 15 titik Independent Check Point (ICP) yang diperoleh di lapangan menggunakan Total Station. Dari analisis yang sudah dilakukan diperoleh hasil ketelitian model 3D adalah sebesar 1,2 cm.
Perencanaan Jalur Pipa Distribusi Sekunder PDAM Menggunakan Metode Analytical Hierarchy Process dan Cost Path Analysis (Studi Kasus : Kecamatan Gunung Anyar ke Zona 3 PDAM Surya Sembada)
Authors: Luberta Sendi Khoirul Irham , Handayani Hepi Hapsari , Nurwatik Nurwatik
Published: July 2024

Zona 3 Pelayanan PDAM Surya Sembada memiliki tekanan air dan debit air terrendah jika dibandingkan dengan zona lain. Hal ini menyebabkan zona 3 belum dapat teraliri air secara keseluruhan dan terus-menerus. PDAM merencanakan pemasangan jaringan pipa baru menuju 3 dengan titik awal berada di Kecamatan Gunung Anyar agar dapat menambah kapasitas air zona 3 tersebut. Dalam penelitian ini digunakan metode Analytical Hierarchy Process (AHP) dan Cost Path Analysis dengan mempertimbangkan beberapa kriteria yaitu kelerengan, arah hadap lereng, penggunaan lahan, jaringan jalan, jaringan sungai, daerah rawan bencana, banjir, dan jenis tanah. Metode AHP digunakan untuk menentukan bobot setiap kriteria dan sub-kriteria. Sedangkan cost path analysis diproses dengan berdasarkan bobot setiap kriteria dan skor sub-kriteria yang didapat dari pembobotan AHP. Didapatkan kriteria dengan bobot tertinggi ialah jaringan jalan sebesar 44%, diikuti kriteria penggunaan lahan sebesar 22%, untuk kriteria lain memiliki bobot antara 4%-10%. Pada penelitian ini direncanakan terdapat beberapa pilihan jalur pipa yaitu sebanyak 3, sehingga proses cost path analysis perlu dilakukan dengan input 3 titik akhir dan didapatkan 3 jalur pipa pilihan. Setelah didapatkan jalur pipa hasil pemodelan cost path analysis, dilakukan analisis kesesuaian mengacu pada SNI pemasangan pipa tahun 2004 serta RDTR Kota Surabaya Tahun 2018-2038. Diperlukan adanya modifikasi jalur pipa dikarenakan untuk masing-masing jalur 1, jalur 2, dan jalur 3 sebesar 12,6 %; 14,0 %; dan 7,4 % dari total panjang jalurnya intersect dengan area pemukiman. Modifikasi dilakukan dengan menggeser bagian jalur pipa yang intersect dengan pemukiman menuju jaringan jalan terdekat dikarenakan jaringan jalan memiliki pengaruh tersesar dalam penelitian ini dan menyesuaikan dengan peraturan. Kemudian, melakukan simulasi tekanan air dan debit air menggunakan software waterGems untuk megetahui tekanan air dan debit air yang mampu dihasilkan setiap jalur pipa dan didapatkan jalur 1 dapat menghasilkan tekanan air rata-rata dan debit air tertinggi masing-masing sebesar 6,096 m dan 77 l/s.
Analisis Data DEM untuk Hidroponik Presisi: Menemukan Lokasi Penyinaran Matahari yang Optimal (Studi Kasus: Rooftop di Politeknik Pertanian Negeri Samarinda)
Authors: Prasetya F. V. Astrolabe Sian , Kurniadin Nia , Fadlin Feri
Published: July 2024

Pertumbuhan penduduk Kalimantan Timur yang sangat cepat dan juga pelaksanaan kegiatan pertanian di Kalimantan Timur yang relatif rendah menimbulkan permasalahan dalam pemenuhan kebutuhan pangan masyarakat di Kalimantan Timur. Dalam usaha meningkatkan pelaksanaan kegiatan pertanian di Kalimantan Timur, perlu dilakukan pertanian skala mikro, yaitu dengan melakukan pertanian hidroponik dengan memanfaatkan lahan kosong di atas gedung (rooftop). Untuk meningkatkan keberhasilan dalam pertanian mikro tersebut, perlu memperhatikan lama penyinaran matahari pada lokasi pertanian tersebut. Dengan berkembangnya teknologi GIS dan Remote Sensing, hal ini dapat memungkinkan untuk dilakukan kajian penentuan lokasi yang optimal untuk pertanian pintar (smart farming) hidroponik, khususnya pada parameter lama penyinaran matahari di lingkungan Politeknik Pertanian Negeri Samarinda. Salah satu data spasial yang dapat digunakan dalam kajian ini adalah data Digital Elevation Model (DEM) dari pesawat nirawak (Unmanned Aerial Vehicle/UAV). Berbagai metode analisis spasial dapat diterapkan untuk dapat mengekstraksi nilai lama penyinaran matahari pada suatu lokasi, salah satunya adalah penentuan area bayangan sinar matahari (Hillshade) dan teknik penjumlahan dengan pembobotan (Weighted Sum). Hasil Dari penelitian ini didapatkan bahwa ada 3 Gedung yang memiliki kriteria cocok sebagai rencana lokasi hidroponik, yaitu antara lain: a) Gedung I, dengan luas 172.5 m2 dan lama penyinaran maksimal 12 jam/hari; b) antara GedungG dan H, dengan luas 130 m2 dan lama penyinaran maksimal 12 jam/hari; serta Gedung E, dengan luas 737,49 m2 dan lama penyinaran maksimal 12 jam/hari. Dari hasil kajian dimana didapatkan area yang sesuai dan memiliki lama penyinaran matahari yang optimal di lingkungan Politeknik Pertanian Negeri Samarinda, memberikan gambaran bagi pelaku pertanian, baik dosen maupun mahasiswa, dapat mengembangkan pertanian pintar hidroponik pada lokasi rooftop tersebut. Selain itu penelitian ini dapat tingkatkan lebih lanjut untuk mengkaji lokasi yang optimal untuk produksi daya mandiri (Panel Surya) sebagai supply daya pada kebutuhan pertanian pintar hidroponik selanjutnya.
Proteomics for early prenatal screening of gestational diabetes mellitus
Authors: Wu Liang , Wang Xiu-Ping , Zhu Yun-Xia , Tan Yan-Ping , Li Chun-Ming
Published: July 2024

In this editorial, we comment on the article by Cao et al . Through applying isobaric tags for relative and absolute quantification technology coupled with liquid chromatography-tandem mass spectrometry, the researchers observed significant differential expression of 47 proteins when comparing serum samples from pregnant women with gestational diabetes mellitus (GDM) to the healthy ones. GDM symptoms may involve abnormalities in inflammatory response, complement system, coagulation cascade activation, and lipid metabolism. Retinol binding protein 4 and angiopoietin like 8 are potential early indicators of GDM. GDM stands out as one of the most prevalent metabolic complications during pregnancy and is linked to severe maternal and fetal outcomes like pre-eclampsia and stillbirth. Nevertheless, none of the biomarkers discovered so far have demonstrated effectiveness in predicting GDM. Our topic was designed to foster insights into advances in the application of proteomics for early prenatal screening of GDM.
Impact of web-based positive psychological intervention on emotions, psychological capital, and quality of life in gastric cancer patients on chemotherapy
Authors: Xin Yu-Yu , Zhao Dan
Published: July 2024

BACKGROUND

Gastric cancer is a malignant digestive tract tumor that originates from the epithelium of the gastric mucosa and occurs in the gastric antrum, particularly in the lower curvature of the stomach.

AIM

To evaluate the impact of a positive web-based psychological intervention on emotions, psychological capital, and quality of survival in gastric cancer patients on chemotherapy.

METHODS

From January 2020 to October 2023, 121 cases of gastric cancer patients on chemotherapy admitted to our hospital were collected and divided into a control group (n = 60) and an observation group (n = 61) according to the admission order. They were given either conventional nursing care alone and conventional nursing care combined with web-based positive psychological interventions, respectively. The two groups were compared in terms of negative emotions, psychological capital, degree of cancer-caused fatigue, and quality of survival.

RESULTS

After intervention, the number of patients in the observation group who had negative feelings toward chemotherapy treatment was significantly lower than that of the control group (P < 0.05); the Positive Psychological Capital Questionnaire score was considerably higher than that of the control group (P < 0.05); the degree of cancer-caused fatigue was significantly lower than that of the control group (P < 0.05); and the Quality of Life Scale for Cancer Patients (QLQ-30) score was significantly higher than that of the control group (P < 0.05).

CONCLUSION

Implementing a web-based positive psychological intervention for gastric cancer chemotherapy patients can effectively improve negative emotions, enhance psychological capital, and improve the quality of survival.
Influence of perinatal factors on full-term low-birth-weight infants and construction of a predictive model
Authors: Xu Liang , Sheng Xue-Juan , Gu Lian-Ping , Yang Zu-Ming , Feng Zong-Tai , Gu Dan-Feng , Gao Li
Published: July 2024

BACKGROUND

Being too light at birth can increase the risk of various diseases during infancy.

AIM

To explore the effect of perinatal factors on term low-birth-weight (LBW) infants and build a predictive model. This model aims to guide the clinical management of pregnant women’s healthcare during pregnancy and support the healthy growth of newborns.

METHODS

A retrospective analysis was conducted on data from 1794 single full-term pregnant women who gave birth. Newborns were grouped based on birth weight: Those with birth weight < 2.5 kg were classified as the low-weight group, and those with birth weight between 2.5 kg and 4 kg were included in the normal group. Multiple logistic regression analysis was used to identify the factors influencing the occurrence of full-term LBW. A risk prediction model was established based on the analysis results. The effectiveness of the model was analyzed using the Hosmer–Leme show test and receiver operating characteristic (ROC) curve to verify the accuracy of the predictions.

RESULTS

Among the 1794 pregnant women, there were 62 cases of neonatal weight < 2.5 kg, resulting in an LBW incidence rate of 3.46%. The factors influencing full-term LBW included low maternal education level [odds ratio (OR) = 1.416], fewer prenatal examinations (OR = 2.907), insufficient weight gain during pregnancy (OR = 3.695), irregular calcium supplementation during pregnancy (OR = 1.756), and pregnancy hypertension syndrome (OR = 2.192). The prediction model equation was obtained as follows: Logit (P ) = 0.348 × maternal education level + 1.067 × number of prenatal examinations + 1.307 × insufficient weight gain during pregnancy + 0.563 × irregular calcium supplementation during pregnancy + 0.785 × pregnancy hypertension syndrome − 29.164. The area under the ROC curve for this model was 0.853, with a sensitivity of 0.852 and a specificity of 0.821. The Hosmer–Leme show test yielded χ 2 = 2.185, P = 0.449, indicating a good fit. The overall accuracy of the clinical validation model was 81.67%.

CONCLUSION

The occurrence of full-term LBW is related to maternal education, the number of prenatal examinations, weight gain during pregnancy, calcium supplementation during pregnancy, and pregnancy-induced hypertension. The constructed predictive model can effectively predict the risk of full-term LBW.
Afetler Karşısında Kırılganlık ve Dirençliliği Temellendirmek: Sermaye Temelli Bütüncül Bir Bilişsel ve Operasyonel Model Önerisi
Authors: Coşkun Serkan , Ulusoy Meliha Demet
Published: July 2024

İnsanlık tarihi, büyük gelişmeler ve ilerlemelere tanık olduğu kadar, doğal ve insan-doğa etkileşimli riskler ve afetlerle de büyük yıkımlara maruz kalmıştır. Bu deneyimler, insanların ve toplumların sınırlarını zorlayarak ve dayanıklılıklarını artırarak afetlere karşı başa çıkma kabiliyetlerini geliştirmelerine yol açmıştır. Ancak her başarı ve önlem, daha karmaşık risklerin ve tehlikelerin ortaya çıkmasına sebep olmuştur, bu da kayıpların ve tecrübe edilen olayların şiddetini artırmış ve yönetilebilirliğini zorlaştırmıştır. Bu eksende, afetlere ve çeşitli risklere karşı bireylerin ve toplumların direncinin nasıl arttırabileceğine ilişkin geniş bir literatür oluşmuştur. Çalışma, bu noktadan hareketle birey ve toplumsal kırılganlık ve dirençliliğin uluslararası literatürde nasıl temellendirildiğini incelemektedir. Böylelikle, ulusal afet literatürünün operasyonel ve kavramsal anlayışını genişletmeyi ve bir model önerisi sunmayı hedeflemektedir. Bu bağlamda, PRISMA protokolü kullanılarak yapılan sistematik derleme ve meta-analiz ile uluslararası literatürden elde edilen veriler analiz edilmiştir. Bulgular, direnç ve kırılganlık kavramlarının afet yönetimindeki merkezi rolünü ve sosyal, ekonomik, insani, fiziki ve kültürel sermayenin bu bağlamdaki önemini vurgulamaktadır. Aynı zamanda sermaye yaklaşımlarına ek sosyal ekosistem sermayesini de alternatif bir sermaye boyutu olarak modele eklemeyi önermektedir.
Letoon Kilisesi, 2022 Yılı Kandil Buluntuları
Authors: Erdoğan Lütfullah Ufuk , Yılmaz Gizem
Published: July 2024

Lykia Bölgesi’nin kutsal alanı olan Letoon, günümüzde Muğla ili, Seydikemer ilçesi sınırları içerisinde yer almaktadır. 2022 kazı sezonunda tiyatro ve nekropol alanlarının yanı sıra Hristiyanlık inancıyla birlikte kutsal alan içerisinde inşa edilmiş olan kilisede kazı ve onarım çalışmaları gerçekleştirilmiştir. Bu çalışmalar sırasında tüm ya da büyük oranda tümlenebilir sekiz adet kandil tespit edilmiştir. Kandiller üç ayrı tip altında incelenmiştir. Bu tipler Lykia’da sıkça karşılaştığımız Lykia Tipi, Kuzey Afrika Tipi ve Küçük Asya/Ephesus Tipi kandillerdir. Aynı kontekst içerisinde değerlendirilen ve beşinin omuz, diskus ve tabanında betimleme görülen bu kandillerin bir kısmı çark bir kısmı ise kalıp yapımıdır. Bu çalışmada sekiz adet pişmiş toprak kandilin tipolojik değerlendirmesi yapılmış ve bu kandiller döneminin benzerleri ile karşılaştırılmıştır. Çalışmada değerlendirilen bu kandillerin, kilisenin kullanım evresiyle paralel olduğu tespit edilmiştir.