bluuebunny/crossref_metadata_2025 huggingface dataset:
Oxygen Toxicity to the Immature Lung—Part II: The Unmet Clinical Need for Causal Therapy
Authors: Behnke Judith , Dippel Constanze M. , Choi Yesi , Rekers Lisa , Schmidt Annesuse , Lauer Tina , Dong Ying , Behnke Jonas , Zimmer Klaus-Peter , Bellusci Saverio , Ehrhardt Harald
Published: October 2021

Oxygen toxicity continues to be one of the inevitable injuries to the immature lung. Reactive oxygen species (ROS) production is the initial step leading to lung injury and, subsequently, the development of bronchopulmonary dysplasia (BPD). Today, BPD remains the most important disease burden following preterm delivery and results in life-long restrictions in lung function and further important health sequelae. Despite the tremendous progress in the pathomechanistic understanding derived from preclinical models, the clinical needs for preventive or curative therapies remain unmet. This review summarizes the clinical progress on guiding oxygen delivery to the preterm infant and elaborates future directions of research that need to take into account both hyperoxia and hypoxia as ROS sources and BPD drivers. Many strategies have been tested within clinical trials based on the mechanistic understanding of ROS actions, but most have failed to prove efficacy. The majority of these studies were tested in an era before the latest modes of non-invasive respiratory support and surfactant application were introduced or were not appropriately powered. A comprehensive re-evaluation of enzymatic, antioxidant, and anti-inflammatory therapies to prevent ROS injury is therefore indispensable. Strategies will only succeed if they are applied in a timely and vigorous manner and with the appropriate outcome measures.
Angiogenin and Copper Crossing in Wound Healing
Authors: Cucci Lorena Maria , Satriano Cristina , Marzo Tiziano , La Mendola Diego
Published: October 2021

Angiogenesis plays a key role in the wound healing process, involving the migration, growth, and differentiation of endothelial cells. Angiogenesis is controlled by a strict balance of different factors, and among these, the angiogenin protein plays a relevant role. Angiogenin is a secreted protein member of the ribonuclease superfamily that is taken up by cells and translocated to the nucleus when the process of blood vessel formation has to be promoted. However, the chemical signaling that activates the protein, normally present in the plasma, and the transport pathways through which the protein enters the cell are still largely unclear. Copper is also an angiogenic factor that regulates angiogenin expression and participates in the activation of common signaling pathways. The interaction between angiogenin and copper could be a relevant mechanism in regulating the formation of new blood vessel pathways and paving the way to the development of new drugs for chronic non-healing wounds.
Molecular Modeling of Signal Peptide Recognition by Eukaryotic Sec Complexes
Authors: Bhadra Pratiti , Helms Volkhard
Published: October 2021

Here, we review recent molecular modelling and simulation studies of the Sec translocon, the primary component/channel of protein translocation into the endoplasmic reticulum (ER) and bacterial periplasm, respectively. Our focus is placed on the eukaryotic Sec61, but we also mention modelling studies on prokaryotic SecY since both systems operate in related ways. Cryo-EM structures are now available for different conformational states of the Sec61 complex, ranging from the idle or closed state over an inhibited state with the inhibitor mycolactone bound near the lateral gate, up to a translocating state with bound substrate peptide in the translocation pore. For all these states, computational studies have addressed the conformational dynamics of the translocon with respect to the pore ring, the plug region, and the lateral gate. Also, molecular simulations are addressing mechanistic issues of insertion into the ER membrane vs. translocation into the ER, how signal-peptides are recognised at all in the translocation pore, and how accessory proteins affect the Sec61 conformation in the co- and post-translational pathways.
Unusual Bioactive Compounds with Antioxidant Properties in Adjuvant Therapy Supporting Cognition Impairment in Age-Related Neurodegenerative Disorders
Authors: Cichon Natalia , Dziedzic Angela , Gorniak Leslaw , Miller Elzbieta , Bijak Michal , Starosta Michal , Saluk-Bijak Joanna
Published: October 2021

Cognitive function decline is strictly related to age, resulting in the loss of the ability to perform daily behaviors and is a fundamental clinical neurodegeneration symptom. It has been proven that an adequate diet, comprehensive nutrition, and a healthy lifestyle may significantly inhibit neurodegenerative processes, improving cognitive functions. Therefore, intensive research has been conducted on cognitive-enhancing treatment for many years, especially with substances of natural origin. There are several intervention programs aimed at improving cognitive functions in elderly adults. Cognitive functions depend on body weight, food consumed daily, the quality of the intestinal microflora, and the supplements used. The effectiveness in the prevention of dementia is particularly high before the onset of the first symptoms. The impact of diet and nutrition on age-associated cognitive decline is becoming a growing field as a vital factor that may be easily modified, and the effects may be observed on an ongoing basis. The paper presents a review of the latest preclinical and clinical studies on the influence of natural antioxidants on cognitive functions, with particular emphasis on neurodegenerative diseases. Nevertheless, despite the promising research results in animal models, the clinical application of natural compounds will only be possible after solving a few challenges.
Epoxyeicosatrienoic Acids and Fibrosis: Recent Insights for the Novel Therapeutic Strategies
Authors: Guan Xin-Xin , Rao Dong-Ning , Liu Yan-Zhe , Zhou Yong , Yang Hui-Hui
Published: October 2021

Organ fibrosis often ends in eventual organ failure and leads to high mortality. Although researchers have identified many effector cells and molecular pathways, there are few effective therapies for fibrosis to date and the underlying mechanism needs to be examined and defined further. Epoxyeicosatrienoic acids (EETs) are endogenous lipid metabolites of arachidonic acid (ARA) synthesized by cytochrome P450 (CYP) epoxygenases. EETs are rapidly metabolized primarily via the soluble epoxide hydrolase (sEH) pathway. The sEH pathway produces dihydroxyeicosatrienoic acids (DHETs), which have lower activity. Stabilized or increased EETs levels exert several protective effects, including pro-angiogenesis, anti-inflammation, anti-apoptosis, and anti-senescence. Currently, intensive investigations are being carried out on their anti-fibrotic effects in the kidney, heart, lung, and liver. The present review provides an update on how the stabilized or increased production of EETs is a reasonable theoretical basis for fibrosis treatment.
Exploration of the Hsa-miR-1587–Protein Interaction and the Inhibition to CASK
Authors: Zhang Lulu , Zhou Jiang , Xu Ming , Yuan Gu
Published: October 2021

Hsa-miR-1587 has been found to be capable of forming G-quadruplex structures and is overexpressed in multiple cancer cell lines. Here, we explored the interactions between miR-1587 and proteins. HuProt™ human proteome microarray was utilized to screen the binding proteins, and it was discovered that CASK could bind to miR-1587 on the base of the G-quadruplex structure. Moreover, reelin and p21, which are downstream of CASK, were downregulated both transcriptionally and translationally by miR-1587, uncovered by q-RT-PCR and Western blot assays. Bioinformatic analysis was performed on STRING and Panther platforms, leading to the discovery that miR-1587 may be involved in intracellular metabolic and transcriptional physiological processes. This study explores the interaction of hsa-miR-1587 with proteins and provides a new strategy for the regulation of G-rich microRNA’s function.
Liquid-Liquid Chromatography Separation of Guaiane-Type Sesquiterpene Lactones from Ferula penninervis Regel & Schmalh. and Evaluation of Their In Vitro Cytotoxic and Melanin Inhibitory Potential
Authors: Luca Simon Vlad , Gaweł-Bęben Katarzyna , Strzępek-Gomółka Marcelina , Jumabayeva Ainur , Sakipova Zuriyadda , Xiao Jianbo , Marcourt Laurence , Wolfender Jean-Luc , Skalicka-Woźniak Krystyna
Published: October 2021

Ferula penninervis Regel & Schmalh. is a perennial plant used in Kazakh traditional folk medicine to treat epilepsy, neurosis, rheumatism, gastroduodenal ulcers, dyspepsia, wounds, abscesses or tumors. The aim of this work was to isolate series of sesquiterpene lactones from a crude methanolic root extract and investigate their in vitro cytotoxic potential against androgen-dependent prostate cancer LNCaP and epithelial prostate PNT2 cells, as well as to evaluate their melanin production inhibitory effects in murine melanoma B16F10 cells stimulated with α-melanocyte-stimulating hormone (αMSH). Two new (penninervin P and penninervin Q) and five known (olgin, laferin, olgoferin, oferin and daucoguainolactone F) guaiane-type sesquiterpene lactones were isolated with the use of a simple and fast liquid-liquid chromatography method. Olgin and laferin showed the most promising cytotoxic effects in LNCaP cells (IC50 of 31.03 and 23.26 μg/mL, respectively). Additionally, olgin, laferin, olgoferin, and oferin (10 μg/mL) potently impaired melanin release (40.67–65.48% of αMSH + cells) without influencing the viability of B16F10 cells. In summary, our findings might indicate that guaiane-type sesquiterpene lactones from F. penninervis could be regarded as promising candidates for further research in discovering new therapeutic agents with anti-prostate cancer and skin depigmentation properties.
The Positive and Negative Immunoregulatory Role of B7 Family: Promising Novel Targets in Gastric Cancer Treatment
Authors: Bolandi Nadia , Derakhshani Afshin , Hemmat Nima , Baghbanzadeh Amir , Asadzadeh Zahra , Afrashteh Nour Mina , Brunetti Oronzo , Bernardini Renato , Silvestris Nicola , Baradaran Behzad
Published: October 2021

Gastric cancer (GC), with a heterogeneous nature, is the third leading cause of death worldwide. Over the past few decades, stable reductions in the incidence of GC have been observed. However, due to the poor response to common treatments and late diagnosis, this cancer is still considered one of the lethal cancers. Emerging methods such as immunotherapy with immune checkpoint inhibitors (ICIs) have transformed the landscape of treatment for GC patients. There are presently eleven known members of the B7 family as immune checkpoint molecules: B7-1 (CD80), B7-2 (CD86), B7-H1 (PD-L1, CD274), B7-DC (PDCD1LG2, PD-L2, CD273), B7-H2 (B7RP1, ICOS-L, CD275), B7-H3 (CD276), B7-H4 (B7x, B7S1, Vtcn1), B7-H5 (VISTA, Gi24, DD1α, Dies1 SISP1), B7-H6 (NCR3LG1), B7-H7 (HHLA2), and Ig-like domain-containing receptor 2 (ILDR2). Interaction of the B7 family of immune-regulatory ligands with the corresponding receptors resulted in the induction and inhibition of T cell responses by sending co-stimulatory and co-inhibitory signals, respectively. Manipulation of the signals provided by the B7 family has significant potential in the management of GC.
Biobanked Glioblastoma Patient-Derived Organoids as a Precision Medicine Model to Study Inhibition of Invasion
Authors: Darrigues Emilie , Zhao Edward H. , De Loose Annick , Lee Madison P. , Borrelli Michael J. , Eoff Robert L. , Galileo Deni S. , Penthala Narsimha R. , Crooks Peter A. , Rodriguez Analiz
Published: October 2021

Glioblastoma (GBM) is highly resistant to treatment and invasion into the surrounding brain is a cancer hallmark that leads to recurrence despite surgical resection. With the emergence of precision medicine, patient-derived 3D systems are considered potentially robust GBM preclinical models. In this study, we screened a library of 22 anti-invasive compounds (i.e., NF-kB, GSK-3-B, COX-2, and tubulin inhibitors) using glioblastoma U-251 MG cell spheroids. We evaluated toxicity and invasion inhibition using a 3D Matrigel invasion assay. We next selected three compounds that inhibited invasion and screened them in patient-derived glioblastoma organoids (GBOs). We developed a platform using available macros for FIJI/ImageJ to quantify invasion from the outer margin of organoids. Our data demonstrated that a high-throughput invasion screening can be done using both an established cell line and patient-derived 3D model systems. Tubulin inhibitor compounds had the best efficacy with U-251 MG cells, however, in ex vivo patient organoids the results were highly variable. Our results indicate that the efficacy of compounds is highly related to patient intra and inter-tumor heterogeneity. These results indicate that such models can be used to evaluate personal oncology therapeutic strategies.
Evaluating Whether Radiofrequency Irradiation Attenuated UV-B-Induced Skin Pigmentation by Increasing Melanosomal Autophagy and Decreasing Melanin Synthesis
Authors: Kim Hyoung Moon , Oh Seyeon , Yang Jin Young , Sun Hye Jin , Jang Miran , Kang Donghwan , Son Kuk Hui , Byun Kyunghee
Published: October 2021

Autophagy is involved in the degradation of melanosomes and the determination of skin color. TLR4 and tumor necrosis factor (TNF) signaling upregulates NF-kB expression, which is involved in the upregulation of mTOR. The activation of mTOR by UV-B exposure results in decreased autophagy, whereas radiofrequency (RF) irradiation decreases TLR4 and TNF receptor (TNFR) expression. We evaluated whether RF decreased skin pigmentation by restoring autophagy by decreasing the expression of TLR4 or TNFR/NF-κB/mTOR in the UV-B-irradiated animal model. UV-B radiation induced the expressions of TNFR, TLR, and NF-κB in the skin, which were all decreased by RF irradiation. RF irradiation also decreased phosphorylated mTOR expression and upregulated autophagy initiation factors such as FIP200, ULK1, ULK2, ATG13, and ATG101 in the UV-B-irradiated skin. Beclin 1 expression and the expression ratio of LC3-I to LC3-II were increased by UV-B/RF irradiation. Furthermore, melanin-containing autophagosomes increased with RF irradiation. Fontana-Masson staining showed that the amount of melanin deposition in the skin was decreased by RF irradiation. This study showed that RF irradiation decreased skin pigmentation by restoring melanosomal autophagy, and that the possible signal pathways which modulate autophagy could be TLR4, TNFR, NF-κB, and mTOR.
Patidegib in Dermatology: A Current Review
Authors: Cosio Terenzio , Di Prete Monia , Di Raimondo Cosimo , Garofalo Virginia , Lozzi Flavia , Lanna Caterina , Dika Emi , Orlandi Augusto , Rapanotti Maria Cristina , Bianchi Luca , Campione Elena
Published: October 2021

Background: Basal cell carcinoma is one of the most common types of non-melanoma skin cancers, which can be locally destructive despite low-rate metastasis. Surgery is the treatment of choice, but it lacks of efficacy on advanced cases. Hedgehog pathway inhibitors are a class of drugs providing a new therapeutic option for patients affected by advanced disease. Besides systemic therapy, such as vismodegib and sonidegib, also topical inhibitors have been developed. Patidegib is able to decrease tumor burden, reducing the adverse effects induced by systemic targeted therapies. Methods: We performed comprehensive research to summarize the use of patidegib in advanced and recurrent aggressive basal cell carcinomas. Only English language human studies were included in the search. Results: Seven trials reported the application of patidegib. Both topical and systemic patidegib demonstrated safety, tolerability, and efficacy in naïve patients with stage II and III basal cell carcinomas, while stage IV disease and not-naïve patients did not show any benefit. Conclusion: Unlike systemic Hedgehog pathway inhibitors, patidegib 2% gel is not associated with systemic adverse effects and allows a better patient management. Considering the multidisciplinary management of neoplasia, in the era of precision medicine, it is mandatory to confide in pharmacogenomics to obtain personalized combined or sequential therapies.
Detecting Diabetic Retinal Neuropathy Using Fundus Perimetry
Authors: Baba Takayuki
Published: October 2021

Fundus perimetry is a new technique for evaluating the light sense in the retina in a point-to-point manner. Light sense is fundamentally different from visual acuity, which measures the threshold for discriminating and perceiving two points or lines, called the minimum cognoscible. The quality of measurement of retinal sensitivity has dramatically increased in the last decade, and the use of fundus perimetry is now gaining popularity. The latest model of fundus perimetry, MP-3, can be used for a wide range of measurements and has an advanced eye tracking system. High background illumination enables accurate measurement of mesopic retail sensitivity. Recent investigations have shown that neuronal damage precedes vascular abnormalities in diabetic retinopathy. The loss of retinal function has also been reported prior to morphological changes in the retina. In this review, the importance of measuring retinal sensitivity to evaluate visual function in the early stages of diabetic retinopathy was discussed. The usefulness of retinal sensitivity as an outcome measure in clinical trials for treatment modalities is also presented. The importance of fundus perimetry is promising and should be considered by both diabetes researchers and clinical ophthalmologists.
Adaptive Mechanisms of Halophytes and Their Potential in Improving Salinity Tolerance in Plants
Authors: Rahman Md. Mezanur , Mostofa Mohammad Golam , Keya Sanjida Sultana , Siddiqui Md. Nurealam , Ansary Md. Mesbah Uddin , Das Ashim Kumar , Rahman Md. Abiar , Tran Lam Son-Phan
Published: October 2021

Soil salinization, which is aggravated by climate change and inappropriate anthropogenic activities, has emerged as a serious environmental problem, threatening sustainable agriculture and future food security. Although there has been considerable progress in developing crop varieties by introducing salt tolerance-associated traits, most crop cultivars grown in saline soils still exhibit a decline in yield, necessitating the search for alternatives. Halophytes, with their intrinsic salt tolerance characteristics, are known to have great potential in rehabilitating salt-contaminated soils to support plant growth in saline soils by employing various strategies, including phytoremediation. In addition, the recent identification and characterization of salt tolerance-related genes encoding signaling components from halophytes, which are naturally grown under high salinity, have paved the way for the development of transgenic crops with improved salt tolerance. In this review, we aim to provide a comprehensive update on salinity-induced negative effects on soils and plants, including alterations of physicochemical properties in soils, and changes in physiological and biochemical processes and ion disparities in plants. We also review the physiological and biochemical adaptation strategies that help halophytes grow and survive in salinity-affected areas. Furthermore, we illustrate the halophyte-mediated phytoremediation process in salinity-affected areas, as well as their potential impacts on soil properties. Importantly, based on the recent findings on salt tolerance mechanisms in halophytes, we also comprehensively discuss the potential of improving salt tolerance in crop plants by introducing candidate genes related to antiporters, ion transporters, antioxidants, and defense proteins from halophytes for conserving sustainable agriculture in salinity-prone areas.
Intranasal Administration of Undifferentiated Oligodendrocyte Lineage Cells as a Potential Approach to Deliver Oligodendrocyte Precursor Cells into Brain
Authors: Gómez-Pinedo Ulises , Matías-Guiu Jordi A. , Benito-Martín María Soledad , Moreno-Jiménez Lidia , Sanclemente-Alamán Inmaculada , Selma-Calvo Belen , Pérez-Suarez Sara , Sancho-Bielsa Francisco , Canales-Aguirre Alejandro , Mateos-Díaz Juan Carlos , Hernández-Sapiéns Mercedes A. , Reza-Zaldívar Edwin E. , Ojeda-Hernández Doddy Denise , Vidorreta-Ballesteros Lucía , Montero-Escribano Paloma , Matías-Guiu Jorge
Published: October 2021

Oligodendrocyte precursor cell (OPC) migration is a mechanism involved in remyelination; these cells migrate from niches in the adult CNS. However, age and disease reduce the pool of OPCs; as a result, the remyelination capacity of the CNS decreases over time. Several experimental studies have introduced OPCs to the brain via direct injection or intrathecal administration. In this study, we used the nose-to brain pathway to deliver oligodendrocyte lineage cells (human oligodendroglioma (HOG) cells), which behave similarly to OPCs in vitro. To this end, we administered GFP-labelled HOG cells intranasally to experimental animals, which were subsequently euthanised at 30 or 60 days. Our results show that the intranasal route is a viable route to the CNS and that HOG cells administered intranasally migrate preferentially to niches of OPCs (clusters created during embryonic development and adult life). Our study provides evidence, albeit limited, that HOG cells either form clusters or adhere to clusters of OPCs in the brains of experimental animals.
Multiplex Site-Directed Gene Editing Using Polyethylene Glycol-Mediated Delivery of CRISPR gRNA:Cas9 Ribonucleoprotein (RNP) Complexes to Carrot Protoplasts
Authors: Klimek-Chodacka Magdalena , Gieniec Miron , Baranski Rafal
Published: October 2021

The aim of this work was to show an efficient, recombinant DNA-free, multiplex gene-editing method using gRNA:Cas9 ribonucleoprotein (RNP) complexes delivered directly to plant protoplasts. For this purpose, three RNPs were formed in the tube, their activity was confirmed by DNA cleavage in vitro, and then they were delivered to carrot protoplasts incubated with polyethylene glycol (PEG). After 48 h of incubation, single nucleotide deletions and insertions and small deletions at target DNA sites were identified by using fluorescent-PCR capillary electrophoresis and sequencing. When two or three RNPs were delivered simultaneously, long deletions of 33–152 nt between the gRNA target sites were generated. Such mutations occurred with an efficiency of up to 12%, while the overall editing effectiveness was very high, reaching 71%. This highly efficient multiplex gene-editing method, without the need for recombinant DNA technology, can be adapted to other plants for which protoplast culture methods have been established.
Measuring Customer Engagement in Social Media Marketing: A Higher-Order Model
Authors: Vinerean Simona , Opreana Alin
Published: October 2021

Customer engagement has emerged as a vital component in social media marketing strategies, prompting considerable interest from both marketers and academics. This study investigates customer engagement (CE) in a framework that includes three antecedents and a main outcome (loyalty). Based on the survey method, we test a proposed model on social media users. The data analysis focuses on exploratory and confirmatory factor analyses, as well as structural equation modeling to test the hypotheses, and a multi-group analysis. The results validate CE as a multidimensional construct and support all hypotheses of the conceptual model. As key contributions, the study reveals involvement as the strongest antecedent of customer engagement and emphasizes the importance of CE in predicting and fostering customer loyalty. This paper adds to the existing body of knowledge on customer–brand relationships by establishing the main drivers for customer engagement in digital settings, with valuable theoretical and practical perspectives. Finally, our findings provide managerial recommendations on the development of social media marketing strategies conveyed to enhance customer engagement.
SUSCEPTIBILIDAD A LA EROSIÓN EN DOS AGROECOSISTEMAS ALTOANDINOS DEL CAUCA
Authors: Muñoz-Gómez Fernando Andrés , Figueroa-Casas Apolinar , Pérez Edier Humberto , Rengifo-Cañizalez Edwin
Published: October 2021

Las características ambientales de los suelos en los agroecosistemas altoandinos los hacen susceptibles a procesos erosivos generados por la intensidad y duración de las lluvias. Estos efectos se intensifican al disminuir la cobertura vegetal en la etapa de preparación del suelo para el cultivo. Por estas razones se trabajo sobres cultivos implantados y se determinó la cantidad de suelo desplazado por escorrentía superficial en lluvia simulada a 100 mm h-1 de intensidad, obteniéndose una media estadística de suelo erodado en terreno para cultivo de 2.6 g y en terreno con pastura de 0.2 g. Esta información permitió desarrollar una evaluación ambiental, usando la matriz de FEARO (oficina federal de revisión y análisis ambientales), con la cual se identificó que los componentes ambientales más afectados son el suelo, flora y la fauna, generando un cambio en las características propias de este ecosistema.
EVALUACIÓN DEL CRECIMIENTO DE Lactobacillus casei Y PRODUCCIÓN DE ÁCIDO LÁCTICO USANDO COMO SUSTRATO EL SUERO DE LECHE DE VACUNO
Authors: Escobar Luis Fernando , Rojas Carlos Andrés , Giraldo Germán Antonio , Padilla-Sanabria Leonardo
Published: October 2021

El Lactobacillus casei es un microorganismo que se utiliza como probiótico ya que genera actividad antagónica contra patógenos causantes de desordenes gastrointestinales, debido a su capacidad inmunomoduladora y a cambios de pH generados por la producción de ácido láctico. Por esta razón, este trabajo se ha enfocado en evaluar la  producción del microorganismo y del ácido láctico, adaptando como sustrato un subproducto de la industria láctea (lacto-suero), que es un gran contaminante al vertido a los cuerpos de agua, para esta investigación el lactosuero es desproteinizado y enriquecido con diferentes cantidades de glucosa. Se lograron estandarizar curvas de crecimiento bacteriano en lacto-suero con una producción celular de 5,9x1010 UFC/mL en 75 h, y de ácido láctico  de 70,39 y 76,24 g/L  en 93 h, con 0% y 5% de glucosa respectivamente. Igualmente se estandarizó un proceso de liofilización para conservar el Lactobacillus casei  producido durante la investigación. Finalmente, se verificó la pureza de la cepa a través del kit API 50CH.
Coronacrisis in the Mechanisms of Cyclic Development of the World and Russian Economies
Authors: Kapkanshchikov Sergey Gennadievich
Published: October 2021

Based on the theory of the cyclical nature of capitalist reproduction in its various (including modern) variations, the author of the article defends the thesis that the pandemic of the new coronavirus was not the root cause of the crisis in the world economy in 2020, but only a factor of its approach in time. Excessive, in the spirit of modern radical liberalism, marketization (commercialization) of country health systems and the desire of a number of nation states to use a large-scale epidemic as a powerful bioengineering weapon are classified as the most significant direct determinants of the global coronacrisis. The mechanism of the influence of the coronavirus epidemic on the state of the world economy is revealed. An attempt is made to compare the coronavirus crisis and the global financial and economic crisis of 2008–2009 with an assessment of the change in the balance of forces between the leading powers in the course of the deployment of these crises. As a «visiting card», the specifics of the current global crisis is characterized by a negative combination of supply shock and demand shock, which radically complicates the construction of an adequate system of anti-crisis regulation of the world and national economies. The place of coronacrisis shocks in the mechanism of the deepening of the Russian autonomous recession is revealed. The effectiveness of the anti-crisis activities of the Government and the Bank of Russia is constructively and critically assessed.
Presence and virulence characterization of Listeria monocytogenes from fish samples in the Black Sea, Turkey
Authors: GOZUTOK Eren , AYDIN Ali
Published: October 2021

Listeria monocytogenes, characterized by a high mortality rate in humans, is a bacterium that causes listeriosis and is found in various aquatic products. The aim of this research was to investigate the presence, serotype distribution, virulence factor genes, and antibiotic susceptibility of L. monocytogenes strains isolated from a total of 500 fish samples of whiting (Merlangius merlangus euxinus) (n:243) and striped red mullet (Mullus surmuletus) (n:257) caught in the Black Sea between the years 2013-2014. Only one (0.2%) L. monocytogenes strain (striped red mullet) was isolated according to the cultural method (EN ISO 11290-1) and confirmed by PCR analysis. The L. monocytogenes strain was identified as serogroup 4b-4d-4e. Furthermore, the strain harboured hlyA, inlA, inlC, inlJ, plcA, plcB, prfA, mpl, actA, monoA-B, flaA, lip 1-2a, fri, iap, and gtcA genes except the dltA gene. On the other hand, L. monocytogenes strain susceptibility to ampicillin, meropenem, erythromycin, trimetophrim/sulfamethoxazole, and penicillin G was evaluated with the disc-diffusion method. According to the results, serogroup 4b-4d-4e isolated from striped red mullet was found to be unique to raw fish and susceptible to all tested antibiotics. In addition, it is considered that carrying out this research in different seas and with different fish species would be appropriate for determining the prevalence and virulence characteristics of L. monocytogenes.
The state of creativity in adolescents with intellectual disabilities
Authors: Yeremenko H.Yu. , Yakovleva S.D. , Sagan O.V.
Published: October 2021

The objective of the article is to investigate empirically and substantiate theoretically the state of creativity in adolescents with intellectual disabilities; to reveal gender differences and changes in creativity during puberty in 13-15-year old adolescents.

Davis's standardized technique was used to determine the respondents’ creativity. Obtained data were processed using Student’s t-test for paired samples. The obtained results showed existing but not realized capabilities of adolescents with intellectual disabilities, so special correctional and developmental work should be performed with them.
Анизотропия проводимости эпитаксиальных плёнок топологического
кристаллического изолятора Pb1-xSnxTe, выращенных
на подложках CdTe/ZnTe/GaAs (013)
Authors: Тарасов А.С. , Ищенко Д.С. , Михайлов Н.Н.
Published: October 2021

Целью работы являлась разработка методики очистки поверхности CdTe/ZnTe/GaAs (013), рост
эпитаксиальных плёнок PbSnTe, PbSnTe:In и изучение их транспортных свойств. Применение
методики получения атомарно-чистой и структурно-упорядоченной поверхности CdTe/ZnTe/GaAs
после ее выдержки в атмосфере позволяет использовать такие структуры для роста PbSnTe и без
отдельной ростовой камеры для CdTe/ZnTe/GaAs. За основу взята методика, успешно используемая
для соединений AIIIB
V и заключающаяся в обработке поверхности в насыщенного парами соляной
кислоты изопропиловом спирте (HCl-iPA) с предростовым прогревом подложек в вакууме.
Матричное тепловидение нового поколения в химии и химической физике
Authors: Вайнер Б.Г.
Published: October 2021

Большинство химических реакций сопровождается выделением теплоты. При этом, как отражалось
в литературе, наблюдаемые температурные изменения способны служить количественным
показателем химических процессов [1]. Более того, информация о температуре в ряде случаев является
решающей для понимания термодинамики и кинетики реакций [2].
Уникальные технические возможности современной ИК термографии (количественного
матричного тепловидения), позволяющие без физического вмешательства в объект исследования
проводить температурные измерения с чувствительностью порядка 0.01 C и выше, реализовать
временное разрешение порядка 0.01 с и короче, дают основания считать этот метод одним из наиболее
подходящих для химических приложений, в том числе, для адсорбции и катализа. Благодаря
современной доступности и своим беспрецедентным свойствам тепловизионный метод исследования
по сути породил новое экспериментальное направление в изучении разнообразных экзотермических и
эндотермических процессов, протекающих в на поверхности твердых тел. Высокая эффективность
применения тепловизионного подхода для этой цели была обоснована и продемонстрирована автором
настоящего доклада в недавнем обзоре [3].
TEORIAS E CAMINHOS PARA O ENSINO DE FILOSOFIA PRESENTES EM UM LIVRO DIDÁTICO PARA A EDUCAÇÃO DE JOVENS E ADULTOS
Authors: da Silva Jaeliton Francisco , Nogueira Crislaine Almeida Oliveira , Lima Cléia da Silva , Santos Herbert Nunes de Almeida , da Silva Manoel Santos , de Oliveira Júnior Valdeck Gomes , Santos Anderson Silva
Published: October 2021

Pensar o ensino da Filosofia na Educação de Jovens e Adultos - EJA -, assim como o ensino dos demais componentes curriculares, é pensar um trabalho educativo que esteja diretamente relacionado com as reais necessidades e peculiaridades dos estudantes que frequentam essa modalidade de ensino. Diante disso, este trabalho teve como objetivo problematizar como os conhecimentos da Filosofia estão sendo abordados em um livro didático específico para a EJA do ensino médio, analisando as proposições metodológicas presentes nesse recurso didático e se as temáticas ali abordadas contemplam as reais necessidades dos estudantes da EJA. As metodologias utilizadas para atingir o objetivo proposto foram a pesquisa bibliográfica de caráter explicativo e de natureza qualitativa e uma pesquisa documental por meio da análise de um livro didático. A análise do livro didático “Tempo, espaço e cultura (Ciências Humanas): ensino médio” possibilitou apresentar aspectos positivos e negativos quanto à sua forma de organização, já que dispõe de uma proposta interdisciplinar fragmentada, informações mal elaboradas, proposta de trabalho fora do contexto social dos estudantes e pouco uso de textos de filósofos. Por outro lado, há sugestões de recursos didático que podem contribuir com as discussões das temáticas filosóficas e assim auxiliar professores e estudantes nas aulas de Filosofia.
Meralarda Tahsis Amacı Değişikliği Talebinin Mevzuata Uygunluk Değerlendirmesi: Kayı Köyü Merası Örneği, Çorum, Türkiye
Authors: UZUN Ferat , İSPİRLİ Kadir , UZUN Ömer Faruk
Published: October 2021

Çorum ili, Merkez ilçesi, Kayı köyünün mera parsellerinde ağaçlandırma ve erozyon kontrolü amacı ile yapılacak çalışmalar için, tahsis amacı değişikliği talebine istinaden “Mera durumu” sınıfının belirlenerek işlemin 4342 sayılı mera kanunu mevzuatına uygunluğu değerlendirilmiştir. Çalışma, 2021 yılı Mayıs ayının son haftasında yapılmış olup, vejetasyon etüdünde modifiye edilmiş tekerlekli lup yöntemi kullanılmıştır. Meranın 109/57 numaralı parseli içerisinde 31, 127/36 numaralı parselinde ise 27 farklı bitki türü tespit edilmiştir. Vejetasyon etüdü değerlerine göre yapılan hesaplamaya göre 127/36 numaralı parselin mera durumu % 30.23 ile “Orta” kategoride yer alırken, 109/57 numaralı parsel ise %20,97 ile “Zayıf” sınıfta yer almıştır. 127/36 ve 109/57 no’lu mera parsellerinin eğim dereceleri ise sırasıyla %5-20 ve %3-7 arasında değişmiştir. Bu verilere göre her iki mera parselinde de mera yönetmeliği mevzuatına göre tahsis amacı değişikliği mümkündür. Diğer yandan her iki mera parselindeki bitki örtüsünün ıslahının mümkün, erozyon riskinin ise düşük olduğu değerlendirilmiştir. Buna göre tahsis amacı değişikliği talebinin, köyün hayvanlarının mera ihtiyaçları da göz önüne alındığında uygun olmayacağı sonucuna varılmıştır.
DYNAMICS FEATURES OF A VIBRATING MACHINE WITH ELASTIC ELEMENT HAVING EXPONENTIAL CHARACTERISTIC OF RESILIENT FORCE
Authors: Altshul Grigory , Gouskov Alexander , PanovkoAlexander Shokhin Grigory , Shokhin Alexander
Published: October 2021

The article analyzes the possibility of using nonlinear elastic elements as a suspension of the working element of resonant vibrating machines with two unbalance vibration exciters is analyzed. The elastic characteristic of the suspension is described by an exponential law, which ensures that the natural frequency remains unchanged regardless of the system mass. Static characteristics of the vibration exciter motors are taken into account. A system of differential equations describing movement of the system depending on the processed material mass is obtained. Amplitude-frequency characteristics depending
on the power supply voltage, as well as on the debalance rotational speed are obtained for different values of material mass. The stability of the obtained periodic solutions is analyzed. The constancy of resonant amplitude and frequency of the working element vibrations at various values of material mass is shown. The results obtained confirm the advisability of using an equalfrequency suspension of the working element for resonant vibrating machines.
CONDITIONS FOR TOPOLOGICAL EQUIVALENCE OFLOCAL QUALITATIVE SINGULARITIES OF DYNAMICALSYSTEMS WITH IMPACT INTERACTIONS
Authors: Gorbikov Sergey P.
Published: October 2021

For the introduced class of dynamical systems with impact interactions, local singularities (six types) are determined. Properties that allow us to prove the topological equivalence of these singularities are described for them. A number of unsolved problems are formulated, which are adjacent to the problems considered in the article.
IMPACT OF ENVIRONMENT CONGRUENCY ON ORGANIZATIONAL PERFORMANCE: THE MEDIATING EFFECT OF CULTURE AND STRATEGY
Authors: Ismail Nancy Haidar
Published: October 2021

This research has been aimed at evaluating the effect on the performance of workers of the Finance Management Institute. Descriptive research approach has been utilized for this. Simple random sampling technique was used to select the respondents for this study. The sample consisted of 25 senior employees and 25 younger employees (thus 50 in total). For data gathering, structured questionnaires have been utilized. The results of the research show that workplace organization has an effect on the respondents. The study has also shown that if management addresses the issues that have been discovered throughout research, the workers would enhance their performance. Such problems include flexibility in the workplace, noise distractions, personal connection of supervisors with workers, the availability of job support, the use of feedback for promotion and incentives. The results of our research also indicated that in order to resolve employee complaints, the company must have regular meetings with its workers as part of the motivating element. Management should develop methods and means of informing its workers of its objectives and plans so as to accomplish its mission, vision and business.
CRIMINAL SANCTION CHARACTERISTICS AGAINST CORPORATION COMMITTED ON CONSUMER PROTECTION OFFENCES IN FEW COUNTRIES
Authors: Setiyono
Published: October 2021

This study aims to analyze the character of the sanctions system against corporations that commit consumer protection crimes. This paper is novel because it seeks to contribute to the current debate in the literature about sanctioned individuals and corporations by comparing the sanction and fines in few countries. Criminal sanctions in force in a country are very dependent on the state's reaction to the deviant activities of the corporations in the society concerned. The state's response was manifested in the sanction system policy towards corporations that commit criminal acts. A sanction system is still conventional, while a sanction system is responsive to the corporate phenomenon. Does this research discuss the sanction system's character against corporations that commit criminal acts of consumer protection? What are the problems of the system of sanctions against corporations that commit these consumer protection crimes? This research was conducted with a normative and comparative approach to comparing the sanctions against corporations that commit criminal acts of consumer protection between the Indonesian Consumer Protection Act and the Consumer Protection Act in several countries, namely Malaysia, the Philippines, Canada, and Finland. This study indicated differences in the character of the criminal sanction system between the Consumer Protection Act of Malaysia, the Philippines, Canada, Finland, and Indonesia against corporations that commit criminal acts in consumer protection. Another characteristic found is a single formulation, namely the threat of criminal fines except for the Indonesian Consumer Protection Act.
LEVELS OF CONTROVERSIAL REASONING OF THE PRE-SERVICE TEACHERS TO SOLVE MATHEMATICAL PROBLEMS
Authors: Subanji  , Rosyadi Alfiani Athma Putri , Emanuel Endrayana Putut Laksminto
Published: October 2021

Controversial reasoning is very important to learn because controversial problems often occur in everyday life. This study examines controversial reasoning in the context of solving mathematical problems. Therefore, this study aims to develop levels of controversial reasoning in solving mathematical problems. The subjects of this study were 185 mathematics education undergraduate students in the sixth and eighth semesters as prospective mathematics teachers. Most of them had taken courses in Pedagogy and Mathematics. The students were given three controversial mathematical problems and interviewed in-depth. The students' thought processes in solving problems construct and determine the characteristics of controversial mathematical reasoning. The study found three controversial mathematical reasoning levels characteristics: initial, exploration, and clarification. At the initial level, the subjects can recognize the controversy on an issue but cannot trace the cause of the controversy itself. At the exploration level, the subjects can explore the components that cause the problem to become controversial but cannot clarify the problem as a solution. At the level of clarification, the subjects can clarify controversial issues using plausible reasons. All the 185 subjects who answered show the answers that can be classified into three levels: initial 55 (29.73%), exploration 52 (28.11%), and clarification 78 (42.16%) subjects.
DRY RICE HUSK FILLER EFFECT TO TENSILE BEHAVIORS OF RECYCLED HIGH-DENSITY POLYETHYLENE (HDPE)-BASED GREEN COMPOSITES
Authors: Susanto Dalhar , Chalid Mochamad , Widyarko  , Chairunnisa Intan , Saskia Cut Sannas
Published: October 2021

The possibility of using plastic waste to manufacture hybrid bio-composite materials with the dry husk of Asian rice (Oryza sativa L.) is investigated. The most polluted and unsustainable plastic waste is High-Density Polyethylene (HDPE) due to its single-use, which decreases in quality if it is reused is selected. The mixtures chosen are local natural fiber and easy to find, potentially a preliminary study of a composites building material. Furthermore, to improve the tensile properties of this hybrid bio-composite material, an additional organic filler is used, such as rice husk (Oryza sativa L.) in a combination of 10%, 12%, and 15%. Samples for this study were processed using the hot press methods based on ASTM D882. Tested for tensile strength, modulus young, yield stress, and elongation is carried out to see an increase in the performance of the biocomposite material. The test results show that the best tensile properties are samples with 12% rice husk, resulting in excellent sample compatibility proofed by Scan Electron Microscopy to study bio-morphological composites. This project has shown that the composites based on natural fiber will be potential building materials due to their improved tensile properties.
Assessment of Agility in Elderly Population of Islamabad
Authors: Khan Maheen , Bashir Sana , Hussain Humaira , Saman Tayyaba , Fatima Rida , Shafi Hina
Published: October 2021

Background: Agility is considered as one of the important components of physical fitness. In older adults, it is of utmost importance in response to any stimulus. The objective of this study was to determine normative values of agility in elderly population of Islamabad.

Methods: A Cross-Sectional Survey was conducted in community settings of Islamabad from February–July 2019 after approval by the Ethical Review Committee of Foundation University Islamabad.  The calculated sample size was found to be 267, but due to missing data, analysis was done on 250(100 females and 150 males).   Participants were selected by convenient sampling. Physically independent participants were included and diseased population (severe musculoskeletal, neurological, and cardiopulmonary disorders), decreased functional status affecting hearing, vision, memory recall was excluded from the study. PAR-Q was utilized in uncovering any possible health risks linked to exercise. For evaluation of agility, the American Alliance for Health, Physical Education, Recreation, and Dance (AAHPERD) Agility Test was performed. Agility scoring is based on time in seconds, with higher score representing less agility, and agility score of less than 62 represents good agility. Data were analyzed through SPSS version 21.

Results: The mean age, BMI and agility score of participants were 60.7±5.81 years, 26±4.30 kg/m² and 22.42±5.2 respectively. There was significant difference (P<0.001) in agility between males and females, with the mean agility score higher in females as compared to males. Similarly, Agility score was significantly high in females as compared to males in BMI range of 18.5 to >30 and all age categories.

Conclusion: Elderly population of Pakistan has good agility score
Dampak Penerapan PSBB Covid-19 dan Harga Saham LQ-45 di Bursa Efek Indonesia (BEI)
Authors: Jecuinna Putry , Zielma Ariel
Published: October 2021

AbstrakTujuan penelitian ini yang telah dibahas untuk mengkaji dampak pandemi Covid-19 dan PSBB pada perkembangan pasar modal di Indonesia khususnya LQ-45.Metode penelitian yang digunakan dalam penelitian ini adalah kualitatif. Penelitian kualitatif bertujuan untuk memperoleh gambaran yang lengkap tentang berbagai hal berdasarkan perspektif manusia. Penelitian ini adalah penelitian yang bersifat komparatif. Penelitian dengan menggunakan studi perbandingan (comparative study) dilakukan dengan cara membandingkan persamaan dan perbedaan. PSBB tahap pertama dilakukan Maret 2020 berdampak pada penurunan harga saham, dimana pemegang saham melakukan panic selling. PSBB tahap pertama kurang efektif dengan meningkatnya kasus positif di Indonesia, maka pemerintah menerapkan PSBB tahap kedua. Dalam kondisi ini pemegang shaam lebih siap dalam menerima informasi tersebut. Pemegang saham dalam menghadapi situasi ini saham mengambil sikap wait and see. Harga saham mengalami penurunan namun dengan presentase yang lebih rendah dibandingkan dengan PSBB tahap pertama. Kata kunci: Covid-19, harga saham, LQ-45, PSBBAbstractThe purpose of this research which has been discussed is to examine the impact of the Covid-19 pandemic and Pembatasan Sosial Skala Besar (PSBB) on the development of the capital market in Indonesia, especially LQ-45. The research method used in this research is qualitative. Qualitative research aims to obtain a complete picture of various things from a human perspective. This research is a comparative research. Research using a comparative study is performed by comparing the similarities and differences. The first phase of the PSBB was carried out in March 2020, impacts on the decline in share prices, which shareholders conducted panic selling. The first phase of the PSBB was less effective as the increasing number of positive cases in Indonesia, so the government implemented the second phase of the PSBB. In this condition, the shareholders are better prepared to receive the information. Shareholders in dealing with this situation took a wait and see attitude. The share price has decreased with a lower percentage compared to the first phase of the PSBB..Keywords: Covid-19, Stock Price, LQ-45, PSBB