bluuebunny/crossref_metadata_2025 huggingface dataset:
Thyroid eye disease with concurrent orbital lymphoma: a radiological surprise
Authors: Das Liza , Singh Usha , Malhotra Bhanu , Bhadada Sanjay Kumar , Rastogi Pulkit , Singh Paramjeet , Dutta Pinaki , Tadepalli Sameeksha
Published: March 2022

Thyroid eye disease (TED) is the most common extra-thyroidal manifestation in Graves’ disease (GD). Additional/concurrent/synchronous pathologies may be present, especially in elderly patients who present with atypical features such as non-axial (or eccentric) proptosis, absence of lid lag and restricted superior extra-ocular movements. A 70-year-old female presented with progressive proptosis of her left eye and diplopia. She was diagnosed with GD a year prior and initiated on carbimazole. On examination, she had eccentric proptosis, restricted superior extra-ocular movements and a palpable mass in the supero-temporal quadrant of the left eye. Her T3 (1.33 ng/mL) and T4 (8.85 µg/dL) were normal with carbimazole. Thyroid-stimulating hormone (TSH)-receptor antibody was positive (3.15 IU/L, reference range <1.75). MRI revealed an enhancing lesion infiltrating the left superior rectus, with concurrent characteristic muscle belly involvement bilaterally. Orbital biopsy showed atypical lymphoid cells (CD20+), suggesting marginal zone lymphoma. CT thorax and abdomen, fluorodeoxyglucose-positron emission tomography and bone marrow examination were normal. The patient was administered orbital radiotherapy for her localised lymphoma and carbimazole was continued. TED is the most common cause of orbital involvement overall and in GD. However, additional or alternative pathology may be present which requires evaluation. MRI can be a useful adjunct in these patients. Orbital lymphoma needs to be staged with workup for disseminated disease. Radiotherapy is the treatment of choice for localized disease. The index case provides evidence for synchronous presentation of dual pathology and highlights the importance of astute clinical examination as well as keeps a low threshold for MRI in selected cases.

Learning points

Thyroid eye disease can co-exist with other ocular pathology, especially in elderly individuals.

Eccentric proptosis, absent lid lag and restriction of eye movements (suggesting tendon involvement) should alert towards the presence of alternative pathology.

Orbital imaging using MRI not only has greater sensitivity in diagnosing radiologically bilateral disease in patients who have unilateral involvement clinically but is also useful to identify concurrent neoplasms.
Efficacy and safety of larotrectinib in patients with TRK fusion-positive thyroid carcinoma
Authors: Waguespack Steven G , Drilon Alexander , Lin Jessica J , Brose Marcia S , McDermott Ray , Almubarak Mohammed , Bauman Jessica , Casanova Michela , Krishnamurthy Anuradha , Kummar Shivaani , Leyvraz Serge , Oh Do-Youn , Park Keunchil , Sohal Davendra , Sherman Eric , Norenberg Ricarda , Silvertown Josh D , Brega Nicoletta , Hong David S , Cabanillas Maria E
Published: March 2022

Objective

Larotrectinib is a highly selective tropomyosin receptor kinase (TRK) inhibitor with demonstrated efficacy across various TRK fusion-positive solid tumours. We assessed the efficacy and safety of larotrectinib in patients with TRK fusion-positive thyroid carcinoma (TC).

Methods

We pooled data from three phase I/II larotrectinib clinical trials (NCT02576431, NCT02122913, and NCT02637687). The primary endpoint was the investigator-assessed objective response rate (ORR) per Response Evaluation Criteria in Solid Tumors v1.1. Secondary endpoints included duration of response (DoR), progression-free survival (PFS), overall survival (OS), and safety. Data cut-off: July 2020.

Results

Twenty-nine patients (median age: 60; range: 6–80) with TRK fusion-positive TC were treated. Tumour histology was papillary (PTC) in 20 (69%) patients, follicular (FTC) in 2 (7%), and anaplastic (ATC) in 7 (24%) patients. Among 28 evaluable patients, ORR was 71% (95% CI: 51–87); best responses were complete response in 2 (7%) patients, partial response in 18 (64%), stable disease in 4 (14%), progressive disease in 3 (11%), and undetermined in 1 (4%) due to clinical progression prior to the first post-baseline assessment. ORR was 86% (95% CI: 64–97) for PTC/FTC and 29% (95% CI 4–71) for ATC. Median time to response was 1.87 months (range 1.64–3.68). The 24-month DoR, PFS, and OS rates were 81, 69, and 76%, respectively. Treatment-related adverse events were mainly grades 1–2.

Conclusion

In TRK fusion-positive TC, larotrectinib demonstrates rapid and durable disease control and a favourable safety profile in patients with advanced disease requiring systemic therapy.

Significance statement

NTRK gene fusions are known oncogenic drivers and have been identified in various histologies of thyroid carcinoma, most commonly in papillary thyroid carcinoma. This is the first publication specifically studying a TRK inhibitor in a cohort of TRK fusion-positive thyroid carcinoma patients. In the current study, the highly selective TRK inhibitor larotrectinib showed durable antitumour efficacy and a favourable safety profile in patients with TRK fusion-positive thyroid carcinoma. Our findings show that patients with advanced non-medullary thyroid carcinoma who may require systemic therapy could be considered for testing for gene fusions by next-generation sequencing.
Personalized drug testing in human pheochromocytoma/paraganglioma primary cultures
Authors: Wang Katharina , Schütze Ina , Gulde Sebastian , Bechmann Nicole , Richter Susan , Helm Jana , Lauseker Michael , Maurer Julian , Reul Astrid , Spoettl Gerald , Klink Barbara , William Doreen , Knösel Thomas , Friemel Juliane , Bihl Michel , Weber Achim , Fankhauser Maria , Schober Laura , Vetter Diana , Broglie Däppen Martina , Ziegler Christian G , Ullrich Martin , Pietzsch Jens , Bornstein Stefan R , Lottspeich Christian , Kroiss Matthias , Fassnacht Martin , Wenter Vera Ursula Julia , Ladurner Roland , Hantel Constanze , Reincke Martin , Eisenhofer Graeme , Grossman Ashley B , Pacak Karel , Beuschlein Felix , Auernhammer Christoph J , Pellegata Natalia S , Nölting Svenja
Published: March 2022

Aggressive pheochromocytomas and paragangliomas (PPGLs) are difficult to treat, and molecular targeting is being increasingly considered, but with variable results. This study investigates established and novel molecular-targeted drugs and chemotherapeutic agents for the treatment of PPGLs in human primary cultures and murine cell line spheroids. In PPGLs from 33 patients, including 7 metastatic PPGLs, we identified germline or somatic driver mutations in 79% of cases, allowing us to assess potential differences in drug responsivity between pseudohypoxia-associated cluster 1-related (n  = 10) and kinase signaling-associated cluster 2-related (n  = 14) PPGL primary cultures. Single anti-cancer drugs were either more effective in cluster 1 (cabozantinib, selpercatinib, and 5-FU) or similarly effective in both clusters (everolimus, sunitinib, alpelisib, trametinib, niraparib, entinostat, gemcitabine, AR-A014418, and high-dose zoledronic acid). High-dose estrogen and low-dose zoledronic acid were the only single substances more effective in cluster 2. Neither cluster 1- nor cluster 2-related patient primary cultures responded to HIF-2a inhibitors, temozolomide, dabrafenib, or octreotide. We showed particular efficacy of targeted combination treatments (cabozantinib/everolimus, alpelisib/everolimus, alpelisib/trametinib) in both clusters, with higher efficacy of some targeted combinations in cluster 2 and overall synergistic effects (cabozantinib/everolimus, alpelisib/trametinib) or synergistic effects in cluster 2 (alpelisib/everolimus). Cabozantinib/everolimus combination therapy, gemcitabine, and high-dose zoledronic acid appear to be promising treatment options with particularly high efficacy in SDHB-mutant and metastatic tumors. In conclusion, only minor differences regarding drug responsivity were found between cluster 1 and cluster 2: some single anti-cancer drugs were more effective in cluster 1 and some targeted combination treatments were more effective in cluster 2.
Spazi di eccezione nel Cile di Pinochet: un’analisi di genere delle violenze sessuali nei centros de detención (1973-1989)
Authors: Toscano Bruno Walter Renato
Published: March 2022

L’articolo intende esaminare le violenze sessuali verificatisi nei campos di prigionia cileni durante il regime di Pinochet (1973-1989) attingendo alla definizione di Stato d’eccezione di Giorgio Agamben. Con l’obiettivo di mostrare la continuità tra la svolta neoliberista del Cile post-golpe e la separazione tra mascolinità e femminilità nei campi di prigionia, verranno analizzate sia le dichiarazioni delle vittime – uomini e donne – sia le testimonianze pubblicate dalle Commissioni di Verità negli anni successivi al regime militare. In questo modo si sottolineerà la funzione biopolitica delle violenze sessuali atte a fissare sul corpo delle vittime un’identità di genere definita e a cui doveva corrispondere un processo di separazione tra sfera privata e sfera pubblica. Infine, l’articolo spiegherà in che modo le violenze sessuali furono il frutto di una più vasta operazione di rifondazionepolitica del Cile successivo al golpe.
Islam y Musulmanes (y no solo) vistos por peregrinos en los diarios del siglo XV
Authors: Borghi Beatrice
Published: March 2022

La movilidad de peregrinos, cruzados y comerciantes de la "Edad Media" ayudó a recopilar y difundir informaciones sobre contextos ambientales y humanos, pero, al mismo tiempo, contribuyó a la construcción de un estereotipo predominante en el pensamiento occidental y en la percepción del "otro" musulmán. Los lugares de las regiones atravesadas eran para los peregrinos áreas inseparables de la sacralidad del país y representaban la frontera con el contexto humano que pertenecía al mundo profano e infiel. Las peregrinationes que nos han llegado parecen moverse en dos niveles paralelos: tradición e innovación. A partir de los diarios de peregrinación a Tierra Santa a finales del Medioevo, se presentan las representaciones de los musulmanes y del Islam, identificando las persistencias  de la cultura milenaria y los cambios producidos a partir de la verdadera curiosidad por conocer y comprender al “otro”. Se prestará  atención al diario de viaje de Anselmo Adorno (1470-1471).
Las relaciones entre Cristianos, Musulmanes y Judíos en Tierra Santa a los ojos de los peregrinos españoles del siglo XVI
Authors: Yordanova Denitsa
Published: March 2022

El presente trabajo pretende ofrecer un panorama general del ambiente y las complejas relaciones entre los representantes de las tres principales religiones monoteístas -cristianos, judíos y musulmanes- y las peculiaridades de su convivencia en Tierra Santa en el siglo XVI. Dichas relaciones están marcadas tanto por la diversidad ideológica y vital de estos grupos, como por la diferencia entre las expectativas de los peregrinos españoles que se dirigían hacia aquellas tierras, y la realidad con la que se encontraban al llegar allí. Estas diferencias entre los peregrinos hacen que en sus relatos estos asuntos se aborden desde perspectivas muy diferentes. Lo que resulta incuestionable es el éxito de sus obras en Europa y la difusión que tuvieron entre los fieles cristianos.
El fenómeno de las peregrinaciones. Reflexiones y prácticas desde una perspectiva multidisciplinar
Authors: Trillo Santamaría Juan Manuel , Sanmartín Israel
Published: March 2022

Texto introductorio al dosier
Veno-Arterial Extracorporeal Membrane Oxygenation and Thrombectomy for Massive Pulmonary Embolism
Authors: Strobel Ray , Khaja Minhaj , Peruri Adithya , Mullen Matthew , Kadl Alexandra , Sharma Aditya , Teman Nicholas
Published: March 2022

Massive pulmonary embolism (PE) is associated with high mortality rates. Pulmonary Embolism Response Team (PERT) collaboration with prompt access to veno-arterial extracorporeal membrane oxygenation (VA ECMO) during mechanical or aspiration thrombectomy for massive PE can be life-saving; ECMO stand-by should be considered for high-risk cases. We describe a case of massive PE treated with intraprocedural VA ECMO during the catheter-directed intervention.
Aberrant Right Subclavian Artery with Kommerell’s Diverticulum and Patent Ductus Arteriosus: Unusual Combination of Congenital Heart Anomalies and Clinical Manifestations in A Neonate
Authors: Xiongqiu Zhuoma , Li Tiange , An Qi
Published: March 2022

Background: A one-month-old neonate presented to the hospital with dyspnea and bloody stool, which happened suddenly and progressed over two days.
Case presentation: Computed tomography and three-dimensional reconstruction of the trachea and heart was done, demonstrating significant trachea stenosis, aberrant right subclavian artery arising from Kommerell’s diverticulum, and patent ductus arteriosus. Reconstruction of the aberrant subclavian artery, resection of the diverticulum, and ligation of ductus arteriosus was performed.
Conclusion: The case reported a rare combination of congenital anomalies and rare clinical manifestations at the same time. We thought the anatomical anomalies caused necrotizing enterocolitis (NEC), which lead to bloody stool.
Bioinformatics Analysis Reveals Hub Genes That May Reduce Inflammation and Complications After Cardiopulmonary Bypass
Authors: Qi Quan , Yan Yibo , Luo Cheng , Fang Chen , Li Yugui , Cai Xiongwei , Ling Guoxing , Song Haitao , Zheng Baoshi
Published: March 2022

Cardiopulmonary bypass (CPB), though indispensable in many cardiac surgery procedures, has several undesirable consequences. The aim of this study was to identify potential genes that may reduce the inflammatory response and complications after CPB. The GSE132176 dataset was selected from the Gene Expression Omnibus (GEO) database and included 10 patients with tetralogy of Fallot and 10 patients with an atrial septal defect who underwent CPB surgery. TSV files were downloaded after GEO2R processing. Protein-protein interaction analysis of common differentially expressed genes (DEGs) was performed using the Search Tool for the Retrieval of Interacting Genes. Gene modules and hub genes were visualized in the protein-protein interaction network using Cytoscape. Enrichment analysis was performed for all important DEGs, modular genes, and hub genes. A total of 72 DEGs were screened, including two functional and one hub gene module. FOS modular genes were primarily enriched in NGF-stimulated transcription, spinal cord injury, and PID AP1 pathway. The ATF3 modular gene was mainly enriched in cytomegalovirus infection and transcriptional misregulation in cancer. Hub gene modules were primarily enriched in the PID AP1 pathway, positive regulation of pri-miRNA transcription by RNA polymerase II, and the PID ATF2 pathway. FOS, JUN, ATF3, and EGR1 were the four most important hub genes; the top three hub genes were involved in the formation of AP-1 and enriched in the AP-1 pathway. Finally, we measured the expression levels of these four genes in patients undergoing CPB via qRT-PCR, and the results were consistent with those obtained in bioinformatic analysis. FOS, JUN, ATF3, and EGR1 and the AP-1 pathway may play key roles in inflammation and complications caused by CPB.
Experiencia y praxis universitaria en la evaluación del estudiantado con discapacidad auditiva
Authors: Zambrano-Steensma Ludmilan
Published: March 2022

Introducción. La praxis pedagógica en la educación actual implica afrontar retos que mejoren el proceso de aprendizaje de sus actores, en los niveles y modalidades del sistema educativo venezolano. La constante transformación en aras de garantizar la calidad educativa, el marco legal que respalda tales esfuerzos y la superación personal y profesional del personal docente responsable del hecho educativo, dan cuenta de la profunda reflexión que decanta en la innovación en atención a la diversidad en la realidad social. Objetivo. De este proceso de reflexión y contraste con la experiencia, surgió esta investigación con diseño no experimental, de campo y nivel descriptivo, cuyo objetivo fue analizar el proceso de evaluación de personas con discapacidad auditiva de la Universidad Pedagógica Experimental Libertador, en el Instituto Pedagógico Rafael Alberto Escobar Lara de Maracay. Metodología. Para ello, según la metodología empleada, se reporta la experiencia de cuatro (4) estudiantes con sordera de la especialidad Educación Especial en Deficiencias Auditivas, durante tres (3) periodos académicos, con base en las entrevistas realizadas, el análisis descriptivo del proceso, así como también de las actividades académicas desarrolladas. Conclusión. Con la información obtenida y el respectivo análisis cualitativo y cuantitativo, se concluyó que las principales dificultades en el proceso de evaluación fueron: el personal docente no se comunica en lengua de señas, ausencia de interpretación del material de clase, ausencia de la persona intérprete a las horas de clase, falta de adecuación de las técnicas e instrumentos empleados para la valoración del aprendizaje y dominio del conocimiento dirigidas a este estudiantado, ausentismo escolar.
What is the association between estrogen and breast cancer?
Authors: Onwude Joseph Loze
Published: March 2022

Aim: There is a historical acceptance about the causal relationship between Estrogens and Breast cancer which has either affected the incidence rate or mortality rate of breast cancer, or could have influenced the uptake or continuation of Estrogen in Hormone Replacement Therapy (HRT). Estrogens are useful either as Estrogen-only HRT (ERT) or as combined Estrogen and Progestogen HRT. There is now a need to clearly differentiate between ERT and HRT in their consequences with regard to breast cancer. This review documents the basis of the historical causal connection and the current situation Methodology: The literature was searched with the following key words: Estrogen, Breast cancer, Estrogen receptors and Menopause;. Incidence and mortality rates of breast cancer associated with Estrogen. Randomized controlled Trials, Observational studies. Cell proliferation, cell differentiation and cell development. Results: The relationship between Estrogen & Breast Cancer with regard to incidence and mortality requires a rigorous scrutiny because: There are prenatal influences which have an impact on exposure to Xenoestrogens across the life course, starting with conception – if not before, giving possible effects on germ cells and gametes. The evidence from observational studies should be interpreted with caution because of procedural inadequacies. The evidence that should be used for care of women is that from Randomised controlled trials because they are geared to infer on cause and effect relationships. The relationship between Estrogen alone for peri-menopause and menopause shows that it does not increase the risk of breast cancer or the mortality from breast cancer. Conclusion: Estrogen alone does not increase the risk and the mortality of breast cancer. The combination of ERT with a progestogen can increase the risk of breast cancer.
Two Different Cretaceous Worlds: Taimyr and Kachin Amber Trichopterofaunas
Authors:   I. I. Schmalhausen Institute of Zoology, National Academy of Sciences of Ukraine, Perkovsky E.
Published: March 2022

Polycentropodidae constitute 55.6% of Taimyr amber caddisfly species with known males, and only 4.8% of caddisfly species with known males in Kachin amber. Micro-caddisflies obviously dominate in Taimyr amber (Archaeopolycentra, Polycentropodidae), Kachin amber (Palerasnitsynus, Psychomyiidae) and New Jersey amber (Hydroptilidae); both Psychomyiidae and Hydroptilidae are absent in Taimyr amber, Polycentropodidae are absent in New Jersey amber and rare in Kachin amber. The domination of Polycentropodidae was proposed as a new characteristics of Baeomorpha Realm, their rarity or absence proposed as a new characteristics of Isoptera Realm.
Trajectories of the Growing-Up in the Psychological Autobiography of Adolescent Secondary School Learners
Authors: Koroleva Natalya N. , Bogdanovskaya Irina M. , Uglova Anna B.
Published: March 2022

Introduction. Currently, the key tasks of education are associated with successful socialization, the development of the personal maturity of the younger generation. At the same time, the socio-cultural transformations of modernity lead to a change in the ways and models of growing-up of schoolchildren. Despite the considerable interest of researchers in this problem, there are practically no works revealing the variable nature of the ways of growing-up of modern adolescents, reflected through their autobiographical ideas about the future. The purpose of the study is to identify the main structural and substantive characteristics of the trajectories of growing-up, reflected in the psychological autobiography of modern schoolchildren, and to determine their gender specificity.
Materials and Methods. To look into the problem, an empirical study was conducted, in which 1 031 people took part – teenagers aged 12 to 17 years. Empirical data was collected by means of a modified version of the method “Psychological Autobiography” by E. Y. Korzhova. Mathematical and statistical analysis of the results was carried out by means of a one-factor analysis of variance (ANOVA), correlation analysis using the Pearson linear correlation coefficient.
Results. In general, the subjective time perspective of adolescents is characterized by a large time span, positive emotional coloring. Based on the results of correlation analysis, the main trajectories of growing-up of modern adolescents are determined. The gender specificity in the structural organization and the content of ideas about the future is revealed. For young men, the trajectories of growing-up associated with independence, a variety of impressions, material success, social recognition, creativity, entertainment, and the development of their inner world are more characteristic. Girls are focused on satisfaction with the process of life, communication, integration of spheres of life.
Discussion and Conclusion. The conclusions made by the authors contribute to the development of modern scientific ideas about the variable and nonlinear character of building a life perspective in the younger generation. The results of the study can be used to build programs of psychological and pedagogical support of the processes of growing up and socialization in the conditions of modern society.
External Migration and Loss of Social Capital in the Regional Society
Authors: Bareev Maxim Yu. , Kurmyshkina Oksana N.
Published: March 2022

Introduction. The relevance of the research is due to the unfavorable migration situation in the Republic of Mordovia. The constant migration outflow of the population affects the composition of the region’s human resource and its social capital. The article examines the social capital of respondents with an active migration strategy.

Materials and Methods. The article is based on the sociological study “Harmonization of social relations of the population of the Republic of Mordovia”, in 2020. 1000 people were interviewed for the study. The quota criteria: gender, age, and place of residence of the respondents. The characteristics and unique features of the migrant’s social capital are determined. The authors identified possible risks for the region associated with migration.

Results. Migration strategies of the population of the Republic of Mordovia are studied. The economic factors are shown as the determinants of possible migration. Thе specific and unique features of social capital of potential migrants have been identified. So, the article defines the reciprocal correlation between factors and migration strategies.

Discussion and Conclusion. According to the results of the study, the economically productive and young part of the population adheres to an active migration strategy. The materials of the article can be useful for regional authorities to solve migration policy issues and to regulate migration flows.
Evaluation of Customized Peripheral Sealing Device Acceptance for Surgical/Medical Masks Among Dental Professionals during Early COVID-19 Pandemic
Authors: Roque-Torres Gina , Kim Jessica , Costa Eliana Dantas , Oyoyo Udochukwu
Published: March 2022

A 3-dimensional (3D) printed custom-frame can improve the peripheral seal of readily available surgical/medical masks. This study aimed to assess the acceptance of a 3D-printed custom-frame with the American Society for Testing and Materials (ASTM) surgical/medical masks and the use of a face shield. A total of 206 subjects from a dental school participated, who answered a multiple-choice questionnaire. Participants received an invitation through the institutional email of the school via Qualtrics platform. 3D printed custom-frames were fabricated for each participant. According to their response, participants were divided into 4 groups: mask only (M), mask and frame (MF), mask and face shield (MFS), and all 3 personal protective equipment (MFFS). Data was analyzed in absolute and relative frequency. The acceptance of a 3D-printed custom-frame in the group MFFS varied between “poor”/’’very poor” (44.7%). It allowed “good” performance of routine procedures (40.3%), but “poor” visual quality (48.1%). Musculoskeletal tolerance and ease to perform movements were adequate. There was no interference in olfactory sensitivity (44.7%) or in the ability to breathe (34.5%). Finally, it showed "moderate pain" (48.1%) on the ear and "no pain" (38.9%) on the head. The 3D-printed custom-frame adapted to ASTM surgical/medical face masks showed reasonable tolerance.  Side effects of ear pain ranging in degrees were noted. Further research is indicated to evaluate safety, comfort, compliance, side effects, and occupational hazards of long-term use of enhanced PPE recommendations.Avoiding the recurrent outbreaks of COVID-19, the use of PPE by the public is necessary. Improper PPE use is a major source of concern for human and environmental health. Preventing such activities can be done by following steps involved in PPE disposals or by getting a new way to re-use such as improving peripherical sealing. Our work highlights that a custom-frame can improve protection, without adverse effects.
Changes in Somatosensory Perception Induced by Trigeminal Injury After Maxillofacial Surgical Procedures
Authors: Luna Velazquez Mariana Irais , Montes Ángeles Claudia Daniela , Pérez-Martínez Isaac Obed
Published: March 2022

Evidence has been reported that shows that somatosensory perception can be altered by a trigeminal injury resulting from maxillofacial surgical procedures. However, the surgical procedures that most frequently cause trigeminal lesions and the risk factors are unknown. In the same way, there is little information on what has been determined in preclinical models of trigeminal injury. This article integrates relevant information on trigeminal injury from both clinical findings and primary basic science studies. This review shows that the age and complexity of surgical procedures are essential to induce orofacial sensory alterations.
PENGEMBANGAN ALAT UKUR KEBAHAGIAAN KERJA
Authors: Mayendry Tania , B. Dunggio Mohammad Rizki , Rahmatika Syahri , A’yun Qurrota , Mubarok Hamdan Syamsul
Published: March 2022

Penelitian ini bertujuan untuk melakukan pengembangan dan memvalidasi alat ukur kebahagiaan kerja. Penyusunan alat ukur kebahagiaan kerja menggunakan dasar teori Seligman (2005). Faktor yang dibuat berjumlah 5 faktor, yaitu berpikir positif terhadap apa yang terjadi, optimis terhadap kemampuan diri, pemecahan masalah, pengendalian diri dan kerja sama. Subjek dalam penelitian ini adalah karyawan yang sedang bekerja. Pengambilan data dilakukan kepada 170 karyawan. Metode analisis data yang digunakan yaitu exploratory factor analysis (EFA) dengan melakukan pengurangan kepada aitem yang memiliki nilai factor loading <0,3. Hasil analisis mendapatkan menunjukkan bahwa terdapat 32 aitem yang valid dengan reliabilitas 0,954. Faktor yang terbentuk pada pengembangan alat ukur ini berjumlah 5 faktor yaitu berpikir positif terhadap apa yang terjadi, optimis terhadap kemampuan diri, pemecahan masalah, pengendalian diri, dan kerja sama. Pengembangan alat ukur kebahagiaan kerja ini dapat menjadi dasar bagi peneliti selanjutnya yang ingin meneliti kebahagiaan kerja sesuai dengan budaya di Indonesia.
PELAYANAN GURU BIMBINGAN DAN KONSELING DALAM MENGATASI KESULITAN BELAJAR PESERTA DIDIK KELAS VII MTsN 3 PESISIR SELATAN
Authors: Fauzy Rahmat , Zeky Asri Atuz
Published: March 2022

Permasalahan di lapangan terlihat masih banyak peserta didik yang mendapatkan nilai rendah, kurang memperhatikan penjelasan guru dengan baik, tidak mengerjakan tugas-tugas,  serta kurang lengkapnya catatan yang mereka miliki, bahkan ada yang berani tidak masuk kelas saat proses belajar mengajar berlangsung. Penelitian ini bertujuan untuk mengetahui pelayanan guru bimbingan dan konseling dalam mengatasi kesulitan belajar peserta didik kelas VII di MTsN 3 Pesisir Selatan. Menggunakan metode deskriptif kualitatif yaitu menggambarkan apa adanya tentang pelayanan guru bimbingan dan konseling dalam mengatasi kesulitan belajar peserta didik kelas VII di MTsN 3 Pesisir Selatan. Sumber data ditentukan secara purposive sampling. Alat pengumpul data yaitu wawancara, observasi dan dokumentasi. Hasil penelitian menunjukkan bahwa layanan konseling individual, konseling kelompok dan layanan penguasaan konten yang dilakukan guru bimbingan dan konseling dapat mengatasi kesulitan belajar peserta didik walaupun masih terdapat beberapa kekurangan. Pelayanan tersebut dilakukan dengan menggunakan pendekatan religius, metodenya memberikan layanan dengan format klasikal,  format kelompok dan format individual. Keberhasilan layanan tersebut dapat terlihat dari perubahan yang terjadi pada peserta didik. Peserta didik terlihat lebih aktif dalam belajar, berkonsentrasi dalam belajar, bisa memahami pelajaran yang diberikan terutama pada mata pelajaran SKI, Bahasa Inggris, PKN dan IPS.
FASILITAS BELAJAR DAN PRESTASI BELAJAR PESERTA DIDIK KELAS VIII MTsN 6 KOTA PADANG
Authors: Yahya Irfan Muhammad , Zulmuqim Zulmuqim , Mardison Safri
Published: March 2022

MTsN 6 Kota Padang memiliki fasilitas belajar yang cukup memadai untuk menunjang prestasi belajar namun belum dimanfaatkan secara semaksimal mungkin oleh peserta didik. Penelitian ini bertujuan untuk mengetahui hubungan antara fasilitas belajar dengan prestasi belajar peserta didik kelas VIII di MTsN 6 Kota Padang. Penelitian mengunakan metode kuantitatif korelasional. Populasi dalam penelitian ini adalah peserta didik kelas VIII di MTsN  6 Kota Padang dengan jumlah 505 orang dan jumlah sampel 83 orang yang di ambil dengan penggunaan random sampling. Penelitian ini mengunakan kuesioner atau angket sebagai instrumen penelitian. Hasil penelitian mengungkapkan bahwa (1) Fasilitas belajar di MTsN 6 Kota Padang di kategorikan sedang dengan persentase 30,12%. (2) Prestasi belajar peserta didik kelas VIII di MTsN 6 Kota Padang dikategorikan tinggi dengan persentase 32,53%. (3) Berdasarkan nilai Koefisien Kolerasi “r” Product Moment dari pengolahan data penelitian diperoleh r xy (0,470) lebih besar dari r tabel (0,283) pada taraf signifikan 5% maka berarti terdapat hubungan yang signifikan dan positif antara fasilitas belajar dengan prestasi belajar, dimana semakin tinggi dimanfaatkan fasilitas belajar maka semakin tinggi prestasi belajar peserta didik kelas VIII di MTsN  6 Kota Padang.
HUBUNGAN DISIPLIN BELAJAR DENGAN HASIL BELAJAR PESERTA DIDIK KELAS VIII DI SMPN 1 V KOTO KAMPUNG DALAM KABUPATEN PADANG PARIAMAN
Authors: Halim Maisha Fajriani , Mardison Safri
Published: March 2022

Penelitian ini berdasarkan fakta lapangan yang penulis temukan di SMPN 1 V Koto Kampung Dalam bahwasabpelanggaran disiplin yang dilakukan peserta didik diantaranya adalah sering keluar di saat jam pelajaran berlangsung, tidak membawa catatan ketika belajar, tidak mengerjakan PR dan tidak memperhatikan guru di saat menerangkan materi pelajaran. Metode penelitian yang digunakan adalah penelitian deskriptif korelasional. Populasi dalam penelitian ini adalah peserta didik, yang berjumlah 167 orang dan jumlah sampel sebanyak 42 orang yang diambil dengan penggunaan teknik Proposional random sampling. Instrumen penelitian yang digunakan adalah angket. Data diolah dengan menggunakan program statistical product and service solution (SPSS) versi 20.00, serta dianalisis dengan menggunakan rumus Product Moment Correlation Coefisien Karl Pearson. Temuan penelitian mengungkapkan bahwa (1) Disiplin belajar peserta didik kelas VIII di SMPN 1 V Koto Kampung Dalam dikategorikan sedang dengan jumlah persentase sebesar 45,24% sedangkan hasil belajar nya dikategorikan Tinggi dengan jumlah persentase sebesar 38,10%. Selain itu dari hasil pengolahan data didapatkan bahwa rhitung = 0,727 lebih besar dari rtabel untuk taraf signifikan 1%= 0,393 dan untuk signifikan 5% = 0,304, sehingga dinyatakan terdapat hubungan yang signifikan antara disiplin belajar dengan hasil belajar peserta didik disiplin belajar dengan prestasi belajar peserta didik.
NILAI ETIKA KONSELOR DALAM MEMBANGUN INTERAKSI EFEKTIF ANTARA KONSELOR DAN KONSELI DI SMP PGRI KOTA DUMAI
Authors: Anriani Rita , Maemonah Maemonah
Published: March 2022

Konselor adalah profesi yang didedikasikan untuk kemasalahatan manusia dan bekerja sesuai dengan keilmuan dan pengalamannya dengan membimbing atas apa yang terjadi baik itu berupa permasalahan maupun tidak. Untuk menjadi konselor harus memili nilai-nilai didalam dirinya salah satunya nilai etika. Nilai etika merupakan segala sesuatu yang menyangkut nilai terpuji. Dalam kehidupan sehari-hari, sering disebut dengan istilah tatakrama atau sopan santun. Nilai etika disebut juga nilai watak atau nilai kepribadian. Tujuan dalam penelitian ini bagaimana implementasi nilai etika konselor dalam membangun interaksi efektif antara konselor dan konseli di SMP PGRI Kota Dumai. Penelitian ini menggunakan deskriptif kualitatif, subjek dalam penelitian ini guru BK di SMP PGRI Kota Dumai yaitu ibu Retty dan 2 siswa. Adapun hasil dari penelitian ini Nilai etika yang dimplementasi oleh guru Bk PGRI Kota Dumai ada empat prinsip dasar mengenai etika yang merupakan bagian dari sebuah pemberian bantuan yang berfungsi untuk meningkatkan etika seorang konselor hingga membangun interaksi yang efektif antar konselor dan konseli yaitu: otonomi, tidak melanggar kode etik, adil dan setia.
PENGARUH PERUNDUNGAN SIBER DI MEDIA SOSIAL DAN BYSTANDER TERHADAP REGULASI EMOSI REMAJA SE-KABUPATEN PEMALANG
Authors: Zuhdi Nihayah Maudya , Mulawarman Mulawarman
Published: March 2022

Tujuan dari penelitian ini yaitu ingin mengetahui seberapa tingkat perundungan siber, regulasi emosi, serta pengaruh perundungan siber di media sosial dan bystander terhadap regulasi emosiremaja Se-Kabupaten Pemalang. Populasi yang diambil di dalam penelitian ini adalah siswa SMP se-Kabupaten Pemalang. Berdasarkan data yang peneliti dapatkan, adapun jumlah populasi dalam penelitian ini berjumlah 1.815 siswa. Kemudian, penentuan sampel dengan menggunakan teknik Proportionate Stratified Random Sampling. Sampel yang digunakan sebanyak 326 siswa yang didasarkan pada proporsi siswa setiap angkatan. Data diambil dengan penyebaran skala kepada responden menggunakan skala psikologis, berupa skala perundungan siber, skala regulasi emosi, dan skala bystander yang masing-masing reliabilitasnya 0,960, 0,772, 0,677. Teknik analisis data yang digunakan ialah analisis deskriptif, serta analisis regresi berganda.Hasil penelitian menunjukkan (1) ada pengaruh yang positif dan signifikan antara perundungan siber terhadap regulasi emosi remaja Se-Kabupaten Pemalang, (2) tidak ada pengaruh yang signifikan antara bystander terhadap regulasi emosi remaja Se-Kabupaten Pemalang, (3) Ada pengaruh yang signifikan dari perundundungan siber di media sosial dan bystander terhadap regulasi emosi remaja Se-Kabupaten Pemalang. Hal ini dikarenakan siswa yang mengalami perundungan siber terutama melalui media sosial baik secara langsung maupun tidak langsung, mereka akan cenderung untuk melalukan pengendalian emosi.
KONSEP APLIKASI LANDASAN DAN PENDEKATAN RELIGIUS DALAM PELAYANAN KONSELING
Authors: Afnilaswati Afnilaswati , Meldawanti Meldawanti , Ardimen Ardimen
Published: March 2022

Tujuan studi ini adalah untuk menjelaskan konsep dan aplikasi landasan religius yang dilengkapi dengan contoh aplikasi dan integrasi berbagai pendekatan religius dalam proses konseling. Metode yang digunakan adalah kajian kepustakaan dengan sumber utama untuk mendapatkan data adalah alqur’an dilengkapi dengan buku referensi dan artikel jurnal terkait dengan landasan religius dalam konseling. Data yang diperoleh dianalisis dengan teknik konten analisis untuk mendapatkan jawaban demi tercapainya tujuan studi ini. Hasil studi ini menunjukkan bahwa konseling religius yaitu proses bantuan secara professional yang dilakukan oleh konselor yang terlatih dan berpengalaman dengan mengintegrasikan nilai-nilai agama dalam proses konseling. Beberapa contoh aplikasi dan integrasi nilai-nilai agama dalam proses konseling adalah konseling dengan pendekatan muhasabah, pendekatan syukur, pendekatan tazkiyatun nafs, pendekatan tadabur al-qur’an, pendekatan zikir, relaksasi religius, dan lainnya.
A preoperatív biliáris sztent hatása a posztoperatív szövődményekre hasnyálmirigyfej-daganat miatt végzett reszekciós műtéteink kapcsán
Authors: Trepák Kornélia , Vajda Kornél , Albert Emőke , Horti Ildikó , Sikorszki László
Published: March 2022

Bevezetés

Pankreászfejtumorok következtében kialakult elzáródásos sárgaság miatt gyakran preoperatív epeúti sztent kerül behelyezésre, ez azonban szövődmény forrása is lehet.

Anyag és módszer

Retrospektív módon elemeztük az osztályunkon 2017. 10. 01. és 2019. 12. 31. közötti időszakban pankreásztumor miatt végzett műtéteinket a preoperatív sztenttel összefüggő mortalitás és morbiditás tekintetében. Vizsgáltuk a multirezisztens baktériumok és a műtéti epemintában előforduló kórokozók spektrumát.

Eredmények

Nyolcvanöt betegnél történt pankreásztumor miatt műtét, ebből 63 pankreászfej reszekció, 3 disztális reszekció, 19 palliáció. A 63 fejreszekción átesett beteg adatait elemeztük. 31 esetben nyitott, 4 esetben laparoszkópos konvertált, míg 28 esetben laparoszkópos műtétet végeztünk. A 36 sztentelt beteg közül 24 férfi (átlagéletkoruk 65,0 év) és 12 nő (átlagéletkoruk 64,0 év) volt. A 27 nem sztentelt beteg közül 14 férfi (átlagéletkoruk 67,9 év) és 13 nő (átlagéletkoruk 58 év) volt. A sztentelt csoportban az epetenyésztés 30/36 (83%), míg a nem sztentelt csoportban 13/27 (48%) esetben bizonyult pozitívnak (P = 0,005). A három leggyakrabban előforduló baktérium mindkét csoportban az Escherichia coli, Enterococcus faecalis, Klebsiella pneumonie voltak, ezt követte a Candida gomba előfordulása. A sztentelt csoportban 8 esetben multirezisztens baktérium előfordulását is észleltük (22,2%). Hat ESBL-termelő baktérium (P = 0,033) és 2 VRE (vancomycin rezisztens törzs) (P = 0,5) volt. A sztentelt csoportból 3, a nem sztentelt csoportból 2 beteget veszítettünk el 30 napon belül. A szövődmények közül a sztentelt-nem sztentelt csoportokban a sebfertőzés 4/0, vérzés 6/2, pankreászsipoly 2/2 és hasüregi tályog 2/3 arányban fordultak elő. Az átlagos ápolási idő a sztentelt csoportban 19,47, a nem sztentelt csoportban 14,62 nap volt (P = 0,14).

Konklúzió

Tekintettel arra, hogy az epeúti sztent megváltoztatja a baktériumflórát, fontos az ennek megfelelő antibiotikus profilaxis megválasztása a morbiditás csökkentésére. Eredményeink és az irodalom alapján is enterococcus és ESBL-termelő törzs ellen is hatásos antibiotikum javasolt. A gomba elleni profilaxis megfontolandó, különösen immunszupprimált esetben. Javasolt továbbá az antibiotikus rezisztencia folyamatos követése.
A Sense of Urgency
Authors: Lercari Nicola , Wendrich Willeke
Published: March 2022

This opening chapter describes the goals and themes of the book. It reflects on historical and contemporary ideas about 'at-risk' cultural heritage and how the recent and rapid developmental trajectory of digital tools in archaeology has, together with geopolitical and environmental crises, re-framed a sense of urgency about archaeology heritage preservation. The chapter also previews the book's structure, its five areas of focus, and the content of the following chapters.
Resolving Analog and Digital Records in Cultural Heritage Sites in Mexico: The Case of Cempoala
Authors: Lucet Geneviève
Published: March 2022

This chapter critically discusses the complexity of identifying, protecting, and documenting Mexico's diverse cultural heritage that contributed to forming the national identity and collective memory in post-colonial time. By discussing various efforts and challenges entailed in protecting pre-Hispanic settlements and historic colonial centers, this contribution provides a critical lens into understanding the sense of urgency related to the protection of this diverse cultural heritage and the important role assigned to its architectural and archaeological documentation. More specifically, this chapter discusses how new digital recording methods provide a more complete, accurate, and objective representation of Mesoamerican architecture than previous analog methods. The author's work in Mexico provides examples of enhancing the preservation of at-risk Mesoamerican architecture by developing documentation standards that proved to be less dependent upon the surveying's subjective quality. The chapter concludes that new digital documentation records that follow cutting-edge standards regarding data capture and digital documentation preservation provide a viable contribution to addressing the sense of urgency in protecting cultural heritage.
Preface
Authors: Levy Thomas E. , Burton Margie M.
Published: March 2022

This chapter describes the destruction by ISIS of archaeological and cultural heritage sites in 2014 and 2015 and the formation of the At-Risk Cultural Heritage and the Digital Humanities Project.
Does the Increase of the Scientific Achievements Lead to Decrease in the Quality of Education?
Authors: Khrustalev M. B. , Turbina N. Yu. , Tishkov A. V. , Maksimova A. A. , Zaripova Z. A.
Published: March 2022

This research article is devoted to the problem of training personnel with higher medical education during the transition to an independent assessment of the graduates’ qualifications and new requirements for the effectiveness of scientific work of universities. The aim of this work was to study the correspondence between the quality of graduate training and the scientific productivity of medical universities. The authors analyzed the results of the accreditation examination of graduates of medical universities as an indicator of the quality of specialists’ training and scientometric indicators in the relevant specialty. As a result of the data analysis, the problem of discrepancy between high scientific productivity of universities and successful completion of accreditation by young specialists was revealed. The authors believe that a possible reason for this discrepancy is the high load on the teaching staff.Furthermore, detailed study of this problem is needed and, most likely, a revision of the approach to the work organization of medical universities’ teaching staff.
Current Chilean Sociology: training, graduation and professional practice
Authors: Sandoval Pablo , Avendaño Octavio
Published: March 2022

The article analyzes the effects of enrollment expansion in the careers of sociology in Chile, in the last two decades. The main argument is that the enrollment expansion is related to the increase in the number of schools and the overcrowding of the university system, as a whole, since the 1990s. The analysis of the problem of sociology students retention, the differences by type of school and the issue of job is based on the data provided by the Ministry of Education for the period 2009-2019. This information is contrasted with historical data about the way sociology has emerged and institutionalized in Chile, starting in the late 1950s, and its later stages of professional and scientific development. After the analysis, it is possible to account for the current conditions in which are carried out the training, graduation and labor insertion processes of those who have opted for sociology careers in different universities.
The Discursive Construction of a New Reality in Olaf Scholz’s Zeitenwende Speech
Authors: Bisiada Mario
Published: March 2022

This article applies Bakhtinian dialogism and the concept of centripetal-centrifugal struggle to critical discourse studies to analyse how powerful and marginalised discourses are brought into competition in political language to justify paradigm changes. I analyse German chancellor Olaf Scholz’s Zeitenwende (‘watershed’) speech, which he gave as a response to the Russian invasion of Ukraine, announcing a radical armament programme and change in foreign policy, a paradigm shift that had previously been unthinkable in German politics. Based on a qualitative analysis using the Appraisal Theory strategies Attitude and Engagement, I identify how Scholz aligns himself with particular powerful discourses, centring some powerful ones and marginalising others, constructing an existential threat for Germany, the so-called watershed, a new situation which casts his policies of German armament as without alternative. The paper demonstrates the strength of the analysis of dialogically contractive and expansive strategies in critical discourse studies.
Sztuka komiksu i problematyka sytuacji granicznej. Estetyka, forma, treści
Authors: Jaworski Marcin
Published: March 2022

Problematyka doświadczenia granicznego była i nadal jest bardzo ważnym zagadnieniem w sztuce dawnej i współczesnej. Tematyka śmierci, winy, utraty, cierpienia przykuwała uwagę artystów reprezentujących różne dyscypliny sztuki, różne estetyki i sposoby ekspresji artystycznej: literaturę i poezję, sztuki plastyczne, film, jak również sztuki multimedialne. Celem artykułu jest zwrócenie uwagi na obszar, który rzadko jest przedmiotem rozważań w odniesieniu do tematyki sytuacji granicznej. Współczesny komiks(szczególnie powieść graficzna) jest – w wbrew utartym opiniom – tym rodzajem sztuki współczesnej, w której poruszane są ważne i niełatwe treści, a ich autorzy szukają takich środków artystycznego wyrazu (opartego na symbiozie słowa i obrazu), aby te niełatwe zagadnienia w sposób niebanalny i atrakcyjny wizualnie przedstawić. Na przykładzie komiksu autorstwa F. Grolleau, J. Royera, Audubon. Na skrzydłach świata, opisującego dzieje życia i twórczości J.-J. Audubona, pioniera ornitologii amerykańskiej i wybitnego ilustratora przyrody, podjęta zostanie próba analizy estetyki, formy i treści wobec problematyki graniczności i relacji między tym, co ludzkie i co nie-ludzkie.
Translational Problems in Audio Description. The Case Study of “Django Unchained” by Quentin Tarantino
Authors: Jabłonka Martyna
Published: March 2022

The main purpose of this paper is to discuss the most common translational problems which occur during the production of audio description (AD), which is one of the modes of audiovisual translation (AVT). The article analyses selected translational problems encountered while scrutinizing the film entitled Django Unchained (2012) by Quentin Tarantino. The analysis is chiefly focused on issues which occur most frequently in the film and seem to be most difficult to solve by audio describers, both in English and in Polish versions of the film. The study compares notions of character description, facial expressions and gestures; these phenomena constitute in fact the core of audio description and particular attention should be paid to accurate rendering of them into the target language. Nonetheless, the article suggests possible strategies of dealing with the above-mentioned obstacles. Proceeding from these considerations, the study proposes conclusions concerning the type of audio description that would probably be the most successful and beneficent to the target audience.