bluuebunny/crossref_metadata_2025 huggingface dataset:
Eculizumab as a New Treatment for Severe Acute Post-infectious Glomerulonephritis: Two Case Reports
Authors: Chehade Hassib , Guzzo Gabriella , Cachat Francois , Rotman Samuel , Teta Daniel , Pantaleo Giuseppe , Sadallah Salima , Sharma Amita , Rosales Ivy A. , Tolkoff-Rubin Nina , Pascual Manuel
Published: July 2021

Acute post-infections glomerulonephritis (APIGN) is a frequent cause of glomerulonephritis and represents the most common cause of acute glomerulonephritis in children. It can evolve to severe acute renal failure and chronic kidney disease or even end-stage kidney disease. The precise pathophysiological mechanisms of APIGN are still incompletely understood. The implication of the alternative complement pathway and the potential benefits of C5 blockade have been recently highlighted, in particular in the presence of a C3 Nephritic Factor (C3Nef), anti-Factor B or H autoantibodies. We report two children with severe APIGN, successfully treated with eculizumab. The first patient presented a severe form of APIGN with advanced renal failure and anuria, associated with a decreased level of C3 and an increased level of soluble C5b-9, in the presence of a C3NeF autoantibody. The second case had a severe oliguric APIGN associated with low C3 level. Kidney biopsy confirmed the diagnosis of APIGN in both cases. Eculizumab allowed full renal function recovery and the avoidance of dialysis in both cases. In conclusion, the alternative and terminal complement pathways activation might be common in PIGN, and in severe cases, eculizumab might help.
The Menstrual Cycle Alters Resting-State Cortical Activity: A Magnetoencephalography Study
Authors: Haraguchi Rika , Hoshi Hideyuki , Ichikawa Sayuri , Hanyu Mayuko , Nakamura Kohei , Fukasawa Keisuke , Poza Jesús , Rodríguez-González Víctor , Gómez Carlos , Shigihara Yoshihito
Published: July 2021

Resting-state neural oscillations are used as biomarkers for functional diseases such as dementia, epilepsy, and stroke. However, accurate interpretation of clinical outcomes requires the identification and minimisation of potential confounding factors. While several studies have indicated that the menstrual cycle also alters brain activity, most of these studies were based on visual inspection rather than objective quantitative measures. In the present study, we aimed to clarify the effect of the menstrual cycle on spontaneous neural oscillations based on quantitative magnetoencephalography (MEG) parameters. Resting-state MEG activity was recorded from 25 healthy women with normal menstrual cycles. For each woman, resting-state brain activity was acquired twice using MEG: once during their menstrual period (MP) and once outside of this period (OP). Our results indicated that the median frequency and peak alpha frequency of the power spectrum were low, whereas Shannon spectral entropy was high, during the MP. Theta intensity within the right temporal cortex and right limbic system was significantly lower during the MP than during the OP. High gamma intensity in the left parietal cortex was also significantly lower during the MP than during the OP. Similar differences were also observed in the parietal and occipital regions between the proliferative (the late part of the follicular phase) and secretory phases (luteal phase). Our findings suggest that the menstrual cycle should be considered to ensure accurate interpretation of functional neuroimaging in clinical practice.
FOXM1-AKT Positive Regulation Loop Provides Venetoclax Resistance in AML
Authors: Chesnokov Mikhail S , Borhani Soheila , Halasi Marianna , Arbieva Zarema , Khan Irum , Gartel Andrei L.
Published: July 2021

Forkhead box protein M1 (FOXM1) is a crucial regulator of cancer development and chemoresistance. It is often overexpressed in acute myeloid leukemia (AML) and is associated with poor survival and reduced efficacy of cytarabine therapy. Molecular mechanisms underlying high FOXM1 expression levels in malignant cells are still unclear. Here we demonstrate that AKT and FOXM1 constitute a positive autoregulatory loop in AML cells that sustains high activity of both pro-oncogenic regulators. Inactivation of either AKT or FOXM1 signaling results in disruption of whole loop, coordinated suppression of FOXM1 or AKT, respectively, and similar transcriptomic changes. AML cells with inhibited AKT activity or stable FOXM1 knockdown display increase in HOXA genes expression and BCL2L1 suppression that are associated with prominent sensitization to treatment with Bcl-2 inhibitor venetoclax. Taken together, our data indicate that AKT and FOXM1 in AML cells should not be evaluated as single independent regulators but as two parts of a common FOXM1-AKT positive feedback circuit. We also report for the first time that FOXM1 inactivation can overcome AML venetoclax resistance. Thus, targeting FOXM1-AKT loop may open new possibilities in overcoming AML drug resistance and improving outcomes for AML patients.
The LncRNA MIR503HG/miR-224-5p/TUSC3 Signaling Cascade Suppresses Gastric Cancer Development via Modulating ATF6 Branch of Unfolded Protein Response
Authors: Lin Han , Wang Jinge , Wang Tong , Wu Jiaming , Wang Peng , Huo Xiaoyan , Zhang Jun , Pan Huayang , Fan Yuying
Published: July 2021

Background

Unfolded protein response (UPR)-mediated tumor-promoting functions have been identified in multiple cancers, and this study focused on investigating the role and molecular mechanisms of UPR in modulating gastric cancer (GC) pathogenesis.

Methods

The bioinformatics analysis was performed to examine the expression status of cancer associated genes in patients with stomach adenocarcinoma (STAD) and predict the targeting sites of miR-224-5p with LncRNA MIR503HG and TUSC3. Genes expressions were quantified by Real-Time qPCR, Western Blot and immunohistochemistry (IHC). Cell proliferation, viability, apoptosis and mobility were evaluated by MTT assay, trypan blue staining assay, flow cytometer and transwell assay, respectively. The binding sites were validated by dual-luciferase reporter gene system assay.

Results

LncRNA MIR503HG and TUSC3 were downregulated, but miR-224-5p was upregulated in GC tissues and cells, in contrast with their normal counterparts. Further gain- and loss-of-function experiments validated that the malignant phenotypes in GC cells, including cell proliferation, invasion, epithelial-mesenchymal transition (EMT) and tumorigenesis, were negatively regulated by LncRNA MIR503HG. Mechanistically, LncRNA MIR503HG upregulated TUSC3 in GC cells through sponging miR-224-5p, resulting in the repression of GC progression. Finally, we validated that knock-down of ATF6, but not other two branches of UPR (PERK1 and IRE1), partially rescued cell proliferation and EMT in the GC cells with LncRNA MIR503HG overexpression.

Conclusions

Targeting the LncRNA MIR503HG/miR-224-5p/TUSC3 signaling cascade suppressed ATF6-mediated UPR, resulting in the blockage of GC development.
Acute Kidney Injury Post-cardiac Surgery in Infants and Children: A Single-Center Experience in a Developing Country
Authors: Aoun Bilal , Daher Ghadi Abu , Daou Karim N. , Sanjad Sami , Tamim Hani , El Rassi Issam , Arabi Mariam , Sharara Rana , Bitar Fadi , Assy Jana , Bulbul Ziad , Degheili Jad A. , Majdalani Marianne
Published: July 2021

Introduction: The incidence of acute kidney injury (AKI) in pediatric patients following cardiac surgery varies between 15 and 64%, with a mortality rate of 10–89% among those requiring dialysis. This variation in the incidence and mortality of AKI across studies is probably due to the inconsistent definitions used for AKI. The purpose of this study is to present our experience with AKI post-cardiac surgery with emphasis on predisposing or aggravating factors.

Patients and Methods: We evaluated the incidence of AKI using the KDIGO criteria in 150 infants and children undergoing cardiac surgeries between 2015 and 2017. Post-operatively, all patients were admitted to the pediatric intensive care unit (PICU) at a tertiary care center in a developing country. This is a retrospective chart review in which data collected included age, gender, type of heart disease, prior cardiac surgeries, RACHS-1 category, and pre- and post-operative creatinine levels. Neonates were not included in this study.

Results: Six percent of the studied patients were below 1 year of age, 84% 1–10 years, and 10% 10–18 years. Fourteen patients (9.3%) developed AKI. Patients with cyanotic heart disease were more prone to develop AKI (78%) compared to those with non-cyanotic heart disease (44%). Children with AKI had a higher length of stay in PICU, 2.56 ± 1.44 vs. 4 ± 2.66 (p- 0.02). Serum lactic acid was higher in patients who developed AKI with a mean value of 6.8 ± 6.9 vs. 2.85 ± 1.55 mmol/l in the non-AKI group (p- 0.03). Lower hemoglobin levels and hyperlactic acidemia were significantly more prevalent in the AKI group. There were five deaths in this series (3.3%), and four of those (80%) were in the AKI group.

Conclusion: Using the KDIGO criteria, the incidence of AKI in infants and children following cardiac surgery was 9.3%. This is slightly lower than in previously published studies where the range was between 15 and 64%. Children with cyanotic cardiac disease, hyperlactic acidemia, and anemia were more prone to developing AKI. Identifying patients at risk might help decrease the risk of post-operative AKI.
Characterization, Identification and Evaluation of Wheat-Aegilops sharonensis Chromosome Derivatives
Authors: Wang Xiaolu , Yu Zhihui , Wang Hongjin , Li Jianbo , Han Ran , Xu Wenjing , Li Guangrong , Guo Jun , Zi Yan , Li Faji , Cheng Dungong , Liu Aifeng , Li Haosheng , Yang Zujun , Liu Jianjun , Liu Cheng
Published: July 2021

Aegilops sharonensis, a wild relative of wheat, harbors diverse disease and insect resistance genes, making it a potentially excellent gene source for wheat improvement. In this study, we characterized and evaluated six wheat-A. sharonensis derivatives, which included three disomic additions, one disomic substitution + monotelosomic addition and two disomic substitution + disomic additions. A total of 51 PLUG markers were developed and used to allocate the A. sharonensis chromosomes in each of the six derivatives to Triticeae homoeologous groups. A set of cytogenetic markers specific for A. sharonensis chromosomes was established based on FISH using oligonucleotides as probes. Molecular cytogenetic marker analysis confirmed that these lines were a CS-A. sharonensis 2Ssh disomic addition, a 4Ssh disomic addition, a 4Ssh (4D) substitution + 5SshL monotelosomic addition, a 6Ssh disomic addition, a 4Ssh (4D) substitution + 6Ssh disomic addition and a 4Ssh (4D) substitution + 7Ssh disomic addition line, respectively. Disease resistance investigations showed that chromosome 7Ssh of A. sharonensis might harbor a new powdery mildew resistance gene, and therefore it has potential for use as resistance source for wheat breeding.
Applying the S-ART Framework to Yoga: Exploring the Self-Regulatory Action of Yoga Practice in Two Culturally Diverse Samples
Authors: Tolbaños-Roche Laura , Menon Praseeda
Published: July 2021

Mindfulness practices form the core of numerous therapeutic programs and interventions for stress reduction and the treatment of different health conditions related to stress and life habits. Ways and means to regulate oneself effectively also form the foundation of the path of yoga in the accomplishment of holistic health and well-being. The self-awareness, self-regulation, and self-transcendence (S-ART) model can be considered as an overarching neurobiological framework to explain the self-regulatory mechanisms of well-being present in mindfulness-based practices. The current study, by connecting and applying the S-ART framework to the self-regulatory mechanisms in yoga and generating related hypotheses, provides a theory-led explanation of the action of yoga practices, which is sparse in the literature. Testing the S-ART model in yoga in two culturally diverse samples, assessing the model-mapped psychological mechanisms of action, and exploring the influence of perseverance in yoga practice are the original contributions of this study. The study sample comprised 362 yoga practitioners and non-practitioners (197 Indian and 165 Spanish), who completed four tests of psychological variables indicative of the aforementioned three S-ART abilities. These tests were Multidimensional Assessment of Interoceptive Awareness (MAIA), Experiences Questionnaire-Decentering (EQ-D) subscale, Difficulties in Emotion Regulation Scale (DERS), and Relational Compassion Scale (RCS). The results indicated significantly better self-awareness and self-regulatory abilities in yoga practitioners (Indian and Spanish in a combination) than non-practitioners, reflected in higher levels of interoceptive awareness and decentering abilities. Moreover, perseverance in yoga practice acted as a significant predictor of self-awareness and self-regulation in practitioners. An analysis of each cultural sample revealed some differences. Yoga practice and perseverance in it acted as a significant predictor of interoceptive awareness and decentering in Indian practitioners having more than 1 year of sustained yoga practice, but for the Spanish participants, physical exercise and frequency of yoga practice acted as better predictors of interoceptive awareness and decentering in comparison to yoga practice and perseverance in it. The obtained results suggested that the S-ART model provided preliminary but promising evidence for the self-regulatory mechanisms of action in yoga practice within a culturally diverse sample of yoga practitioners. This study also widens the scope of generating further hypotheses using the S-ART theoretical framework for testing the self-regulatory mechanisms of action in yoga practice.
Phonetically Grounded Structural Bias in Learning Tonal Alternations
Authors: Huang Tingyu , Do Youngah
Published: July 2021

This study investigates the hypothesis that tone alternation directionality becomes a basis of structural bias for tone alternation learning, where “structural bias” refers to a tendency to prefer uni-directional tone deletions to bi-directional ones. Two experiments were conducted. In the first, Mandarin speakers learned three artificial languages, withbi-directionaltone deletions,uni-directional, left-dominantdeletions, anduni-directional, right-dominantdeletions, respectively. The results showed a learning bias towarduni-directional, right-dominantpatterns. As Mandarin tone sandhi is right-dominant while Cantonese tone change is lexically restricted and does not have directionality asymmetry, a follow-up experiment trained Cantonese speakers either on left- or right-dominant deletions to see whether the right-dominant preference was due to L1 transfer from Mandarin. The results of the experiment also showed a learning bias toward right-dominant patterns. We argue that structural simplicity affects tone deletion learning but the simplicity should be grounded on phonetics factors, such as syllables’ contour-tone bearing ability. The experimental results are consistent with the findings of a survey on other types of tone alternation’s directionality, i.e., tone sandhi across 17 Chinese varieties. This suggests that the directionality asymmetry found across different tone alternations reflects a phonetically grounded structural learning bias.
Mindfulness-Based Cognitive Therapy in Major Depressive Disorder: A Study Protocol of a Randomized Control Trial and a Case–Control Study With Electroencephalogram
Authors: Zhang Tianran , Wang Lanlan , Bai Yanle , Zhao Wenqing , Wu Yanru , Jiang Wenhui , Fan Qing , Qiu Jianyin
Published: July 2021

Background: In this report, a study protocol for a randomized control trial is presented in an attempt to explore the efficacy of mindfulness-based cognitive therapy (MBCT) for major depressive disorder (MMD), and a case–control study is conducted to find the difference in electroencephalograms (EEGs) between MMD and normal controls.

Design: Seventy Chinese patients with MMD will be chosen for random division in the MBCT group or medication group, with half of the participants receiving common medication treatment [selective serotonin reuptake inhibitors (SSRIs)] and half receiving MBCT as a supplement to the common medication treatment. All participants, namely, 70 MMD cases and 35 matched normal controls, will be tested by a range of scales and EEG at baseline (week 0), mid-intervention (weeks 2, 4, and 6), post-intervention (week 8), and 6-months follow-up (weeks 12, 20, and 32).

Discussion: The findings of this study will provide a positive reference for the treatment of depression and future research on MBCT treatment mechanism.

Trial Registration: NCT03558256. Registered: June 13, 2018—retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT03558256.
Intra-household Variation in Pathways to Care for Epilepsy and Mental Disorders in Eastern Uganda
Authors: Sarkar Nandini D. P. , Bardaji Azucena , Baingana Florence K. , Rivera Joan Muela , Criel Bart , Bunders-Aelen Joske , Grietens Koen Peeters
Published: July 2021

Integrating mental, neurological, and substance use (MNS) health care into the public health system has become a global priority, with mental health, and well-being now being part of the Sustainable Development Goals. In the aim to provide good quality care for MNS disorders, understanding patients' pathways to care is key. This qualitative study explores the pathways to care of patients attending an outpatient mental health clinic of a district hospital in eastern rural Uganda, from the perspectives of their caregivers. Twenty seven in-depth interviews were conducted with caregivers of MNS patients visiting the clinic, with a focus on four case-presentations. Data analysis consisted of thematic and emergent content analyses using NVivo 11. Results across all interviews highlight that chosen help-seeking itineraries were largely pluralistic, combining and alternating between traditional healing practices, and biomedical care, regardless of the specific MNS disorder. Intra-household differences in care seeking pathways—e.g., where one patient received traditional help or no care at all, while the other received biomedical care—depended on caregivers' perceived contextual illness narrative for each patient, in combination with a variety of other factors. If interpreted as a form of bewitchment, traditional medicine and healing was often the first form of care sought, while the mental health clinic was seen as a recourse to “free” care. Patients, especially younger children, who showed visible improvements once stabilized on psychotropic medication was a source of motivation for caregivers to continue with biomedical care at the mental health clinic. However, stock-outs of the free psychotropic medication at the clinic led to dissatisfaction with services due to out-of-pocket expenses and precipitated returning to alternative therapy choices. This article showcases the importance of understanding the complex and varied combinations of individual, cultural, socioeconomic and structural factors that may affect caregivers' choices of pathways to care for patients with MNS disorders in eastern rural Uganda. These cumulative complex processes and context-specific help-seeking behaviors, which ultimately impact patient treatment and MNS health outcomes, need to be first acknowledged, understood and taken into account if we are to promote more inclusive, effective and integrated public mental health systems globally.
Promote or Inhibit: Economic Goal Pressure and Residents' Health
Authors: Zhong Min , Wang Peng , Ji Ming , Zeng Xi-Hao , Wei Hong-Xiang
Published: July 2021

This paper aimed to identify the relationship between the pressure to reach economic growth targets and residents' health by applying a panel fixed effects model, a Sobel-Goodman mediation effects test and a regulatory effects model to the inland provinces of China. The empirical results verify that the pressure to reach economic growth targets in these regions reduces the level of residents' health. Moreover, the effect in developing regions is significantly stronger than that in developed regions, and the effect in the northern region is significantly stronger than that in the southern region. The mediation effects test found that the pressure to reach economic growth targets has led to an upsurge in PM2.5 concentration and an increase in the output of industrial solid waste, thereby threatening residents' health. The regulatory effects model highlights that enhancing public awareness could weaken the negative impact of the pressure to reach economic growth targets on residents' health, while the expansion of industrial production will aggravate the negative impact. In the process of economic growth, the government should set reasonable economic growth targets, pay attention to the construction of the environmental protection legal system, implement energy- conservation and emission reduction measures and increase public awareness of environmental protection to ensure residents' health.
Streetscapes as Surrogate Greenspaces During COVID-19?
Authors: Fischer Leonie K. , Gopal Divya
Published: July 2021

In 2020, the spread of COVID-19 (SARS-CoV-2) globally led to severe crisis, disruption and hardship in both private and public life. In such times of distress, access to urban greenspaces is essential for physical and mental wellbeing. However, globally implemented lockdowns deprived many people of freely visiting greenspaces. Inequality in access to urban greenspaces was apparent at global scales. Consequently, many people took to streets for outdoor activities due to its easy accessibility. We, therefore, aimed to study the usage and relevance of streetscapes for outdoor activities during a crisis. We hypothesised that streetscapes supported diverse outdoor activities, functioning as surrogate urban greenspaces. We distributed an online questionnaire to over 400 international respondents. Our results clearly showed that people used streetscapes during this period for a variety of activities, many of which were also reported as their main physical activity. Walking was the most frequent activity in streetscapes globally, and independent from sociocultural characteristics. Other activities reported such as jogging and cycling also aligned generally with main physical activities of people, but differed between countries and people's sociocultural background. In summary, more than one third of respondents from lower-income countries reported not having had access to a greenspace, whereas 8% reported the same in high-income countries. Our results highlight the important role of streetscapes in facilitating people's regular physical activities during the pandemic. Recognising streetscapes as important public outdoor spaces within residential neighbourhoods could help counteract the inequality in greenspace access, an issue that seems more relevant than ever before.
Uptake of Arsenic by Irrigated Vegetables and Cooked Food Products in Burkina Faso
Authors: Clair-Caliot Guillaume , Marks Sara J. , Hug Stephan J. , Bretzler Anja , N'guessan N'goran Djo , Tihe Sussue Franck Kevin , Lalanne Franck
Published: July 2021

As compared to the Asian lowlands, environmental exposure to arsenic (As) in West Africa has received little attention. Recent studies have found geogenic As contamination of groundwater in many regions in Burkina Faso. As-contaminated groundwater is used for drinking and increasingly also for the irrigation of staple foods. This study assesses the extent to which irrigation and cooking of staple foods in Burkina Faso influence plant uptake and dietary consumption of As, respectively. Using a greenhouse experimental setup, we evaluated the transfer of As from irrigation water spiked with 0, 100, 500, and 1,000 μg/L As(V) to the organs and edible parts of seven commonly consumed vegetables (amaranth, carrot, green bean, lettuce, okra, spinach, and tomato). Next, we cooked the greenhouse-cultivated vegetables and externally purchased foods with As-free and As-spiked waters. The As content in all plant organs increased with increasing As in the irrigation water. With 500 μg/L, the concentrations of As in the edible parts (ordered from highest to lowest) were as follows: spinach (6.6 ± 0.5 μg/g); lettuce (3.9 ± 0.1 μg/g); carrot (3.5 ± <0.1 μg/g); amaranth (2.2 ± <0.1 μg/g); okra (0.9 ± <0.1 μg/g); green bean (0.8 ± <0.1 μg/g); and tomato (0.2 ± <0.1 μg/g). The edible parts of leafy vegetables irrigated with As-spiked water had a higher average As content (4.9 ± 4.5 μg/g) than root (2.9 ± 2.0 μg/g) and fruit/pod vegetables (0.8 ± 1.1 μg/g). Cooking with an excess volume of As-free water reduced the As content in the cooked vegetables by 39% on average, while cooking with As-contaminated water transferred As to the cooked food. The As content in steamed foods was 8 to 18 times lower than in boiled foods. Based on human health risk estimates, we generally recommend to avoid planting leafy and root vegetables in areas with As concentrations above 100 μg/L in irrigation water. In areas with elevated As contamination, mitigation strategies include the cultivation of fruit/pods vegetables such as tomato and okra and steaming the food instead of boiling.
COVID-19, Inter-household Contact and Mental Well-Being Among Older Adults in the US and the UK
Authors: Hu Yang , Qian Yue
Published: July 2021

Interacting with family members and friends from other households is a key part of everyday life and is crucial to people’s mental well-being. The COVID-19 pandemic severely curtailed face-to-face contact between households, particularly for older adults (aged 60 and above), due to their high risk of developing severe illness if infected by COVID-19. In-person contact, where possible, was largely replaced by virtual interaction during the pandemic. This article examines how inter-household contact in face-to-face and virtual forms, as well as combinations of the two forms of contact, related to older adults’ mental well-being during the pandemic. Data from two national longitudinal surveys, collected from the same respondents before (2018–2019) and during (June 2020) the pandemic, were comparatively analysed: the Health and Retirement Study in the US and Understanding Society in the UK. The findings showed a notable increase in loneliness in the US and a decline in general mental well-being in the UK following the outbreak of COVID-19. In both countries, more frequent inter-household face-to-face contact during the pandemic was associated with better general mental well-being, but inter-household virtual contact, via means such as telephone and digital media, was not associated with general mental well-being in either the US or the UK. In the US, older adults who engaged more frequently in virtual contact were more likely to feel lonely during the pandemic, particularly if their face-to-face contact was limited. In both countries, the increase in loneliness following the outbreak of the pandemic was greater for older adults who reported more virtual contact. The findings suggest that household-centred crisis management during the COVID-19 pandemic had unintended mental health implications in both the US and the UK, despite contextual differences between the two countries. Although face-to-face contact between households helped to sustain older adults’ mental well-being, virtual contact was not a qualitatively equivalent alternative. The findings also provide an important evidence base for informing policy developments and for supporting the mental health of older people during the COVID-19 pandemic and in the longer term.
Short-Term, Equipment-Free High Intensity Interval Training Elicits Significant Improvements in Cardiorespiratory Fitness Irrespective of Supervision in Early Adulthood
Authors: Sian Tanvir S. , Inns Thomas , Gates Amanda , Doleman Brett , Gharahdaghi Nima , Atherton Philip J. , Lund Jon N. , Phillips Bethan E.
Published: July 2021

Introduction: Serious health implications from having low levels of cardiorespiratory fitness (CRF) and being overweight in young adulthood are carried forward into later life. High-intensity interval training (HIIT) is a time-effective, potent stimulus for improving CRF and indices of cardiometabolic health. To date, few studies have investigated the use of equipment-free HIIT or the impact of supervision for improving CRF via HIIT.

Methods: Thirty healthy young adults (18–30 y) were randomised to 4 weeks (12 sessions) equipment-free, bodyweight based supervised laboratory HIIT (L-HIIT), unsupervised home HIIT (H-HIIT) or no-intervention (CON). Utilised exercises were star jumps, squats and standing sprints. Measurements of CRF (anaerobic threshold (AT) and VO2peak), blood pressure (BP), body mass index (BMI), blood glucose and plasma insulin by oral glucose tolerance test (OGTT), and muscle architecture were performed at baseline and after the intervention.

Results: When compared to the control group, both HIIT protocols improved CRF (AT: L-HIIT mean difference compared to the control group (MD) +2.1 (95% CI: 0.34–4.03) ml/kg/min; p = 0.02; H-HIIT MD +3.01 (1.17–4.85) ml/kg/min; p = 0.002), VO2peak: L-HIIT (MD +2.94 (0.64–5.25) ml/kg/min; p = 0.01; H-HIIT MD +2.55 (0.34–4.76) ml/kg/min; p = 0.03), BMI (L-HIIT MD −0.43 (−0.86 to 0.00) kg/m2; p = 0.05; H-HIIT: MD −0.51 (−0.95 to −0.07) kg/m2; p = 0.03) and m. vastus lateralis pennation angle (L-HIIT MD 0.2 (0.13–0.27)°; p < 0.001; H-HIIT MD 0.17 (0.09 to 0.24)°; p < 0.001). There was no significant change in BP, blood glucose or plasma insulin in any of the groups.

Conclusions: Four weeks time-efficient, equipment-free, bodyweight-based HIIT is able to elicit improvements in CRF irrespective of supervision status. Unsupervised HIIT may be a useful tool for counteracting the rise of sedentary behaviours and consequent cardiometabolic disorders in young adults.
Finger Millet [Eleusine coracana (L.) Gaertn]: An Orphan Crop With a Potential to Alleviate the Calcium Deficiency in the Semi-arid Tropics of Asia and Africa
Authors: Maharajan Theivanayagam , Antony Ceasar Stanislaus , Ajeesh Krishna Thumadath Palayullaparambil , Ignacimuthu Savrimuthu
Published: July 2021

Finger millet plays a vital role in the food and nutritional security of many people in developing countries particularly in Asia and Africa. It is a staple food for poor people in many regions of Asian (India, China, Nepal, and Sri Lanka etc.) and African (South Africa, Ethiopia, Kenya, Uganda, and Nigeria etc.) countries. Finger millet contains nutrient rich components such as dietary fibers, minerals, vitamins, and phytochemicals that include phenolic compounds with several potential health benefits. Calcium (Ca) is an important macronutrient for healthy life of plants, humans and animals. It plays an indispensable role in structure and signaling and its deficiency causes low bone density, osteoporosis, colon cancer etc. Finger millet grains contain exceptionally higher amount of Ca (>300 mg/100 g) when compared to other major cereals. Ca transporter and sensor family genes are involved in the uptake, transport and accumulation of Ca. Understanding the molecular mechanisms of Ca transporter and sensor family genes is important for growth, development and seed fortification in finger millet. Expression analysis of Ca transporter and sensor family genes has been carried out in various tissues of finger millet. Only a very little research work has been done to understand the Ca accumulation in the grains of finger millet. In this review, we discuss the nutritional importance and health benefits of finger millet. We discuss the studies on Ca sensor, accumulation and transport genes that help to improve the grains of finger millet with special reference to Ca. Improved Ca content in finger millet may help to alleviate the Ca deficiency throughout the world particularly in the semi-arid tropics of Asia and Africa.
Effect of Hydrophobic Silica Nanochannel Structure on the Running Speed of a Colloidal Damper
Authors: Chen Gengbiao , Liu Zhiwen
Published: July 2021

A colloidal damper (CD) can dissipate a significant amount of vibrations and impact energy owing to the interface power that is generated when it is used. It is of great practical significance to study the influence of the nanochannel structure of hydrophobic silica gel in the CD damping medium on the running speed of the CD. The fractal theory was applied to observe the characteristics of the micropore structure of the hydrophobic silica gel by scanning electron microscopy (SEM), the primary particles were selected to carry out fractal analysis, and the two-dimensional fractal dimension of the pore area and the tortuous fractal dimension of the hydrophobic silica gel pore structure were calculated. The fractal percolation model of water in hydrophobic silica nanochannels based on the slip theory could thus be obtained. This model revealed the relationship between the micropore structure parameters of the silica gel and the running speed of the CD. The CD running speed increases with the addition of grafted molecules and the reduction in pore size of the silica gel particles. Continuous loading velocity testing of the CD loaded with hydrophobic silica gels with different pore structures was conducted. By comparing the experimental results with the calculation results of the fractal percolation model, it was determined that the fractal percolation model can better characterize the change trend of the CD running velocity for the first loading, but the fractal dimension was changed from the second loading, caused by the small amount of water retained in the nanochannel, leading to the failure of fractal characterization.
Oxidative Strong Metal–Support Interactions
Authors: Du Xiaorui , Tang Hailian , Qiao Botao
Published: July 2021

The discoveries and development of the oxidative strong metal–support interaction (OMSI) phenomena in recent years not only promote new and deeper understanding of strong metal–support interaction (SMSI) but also open an alternative way to develop supported heterogeneous catalysts with better performance. In this review, the brief history as well as the definition of OMSI and its difference from classical SMSI are described. The identification of OMSI and the corresponding characterization methods are expounded. Furthermore, the application of OMSI in enhancing catalyst performance, and the influence of OMSI in inspiring discoveries of new types of SMSI are discussed. Finally, a brief summary is presented and some prospects are proposed.
Associations between Personality Traits and Basal Cortisol Responses in Sailing Athletes
Authors: Limone Pierpaolo , Sinatra Maria , Ceglie Flavio , Monacis Lucia
Published: July 2021

There is a paucity of literature regarding the psycho-physiological profiles of sailors on board. This study aimed at providing empirical evidence on the individual differences between bowmen and helmsmen taking into account a biopsychological perspective. To this purpose, sailors’ profiles were examined by focusing on the association between personality traits and basal cortisol. The sample was composed of 104 athletes (Mage = 21.32, SD = 0.098; F = 35%), who fulfilled a self-reported questionnaire including a socio-demographic section and the Big Five questionnaire. Cortisol samples were collected on the day before the competition, within 30 min after awakening. T-test analysis showed significant differences on cortisol levels: bowmen obtained higher levels on cortisol responses compared to helmsmen. No differences emerged on personality traits between athletes’ roles. Bivariate associations showed positive associations of cortisol responses with extraversion and conscientiousness in bowmen, whereas no significant associations of cortisol with personality traits were found in helmsmen. Regression analyses confirmed that sex and extraversion predicted higher level of cortisol responses. Results were discussed in terms of a bio-psychosocial theoretical approach and provided findings on the relationships between personality trait and the hypothalamus-pituitary adrenal (HPA) system in dinghy sailors. Suggestions for a more suitable selection of sailor roles were given to coaches in order to improve athletes’ performance.
TEI-DTA: Optimizing a Vehicular Sensor Network Operating with Ultra-Low Power System-on-Chips
Authors: Lee Seung-Yeong , Lee Jae-Hyoung , Lee Jiyoung , Lee Woojoo
Published: July 2021

In the era of the Internet of Things (IoT), the interest and demand for embedded systems have been explosively increasing. In particular, vehicular sensor networks are one of the fields where IoT-oriented embedded devices (also known as IoT devices) are being actively used. These IoT devices are widely deployed in and out of the vehicle to check vehicle conditions, prevent accidents, and support autonomous driving, forming a vehicular sensor network. In particular, such sensor networks mainly consist of third-party devices that operate independently of the vehicle and run on their own batteries. After all, like all battery-powered embedded devices, the IoT devices for the vehicular sensor network also suffer from limited power sources, and thus research on how to design/operate them energy-efficiently is drawing attention from both academia and industry. This paper notes that the vehicular sensor network may be the best application for ultra-low power system on-chips (ULP SoCs). The ULP SoCs are mainly designed based on ultra-low voltage operating (ULV) circuits, and this paper aims to realize the energy-optimized driving of the network by applying state of the art (SoA) low-power techniques exploiting the unique characteristics of ULV circuits to the IoT devices in the vehicular sensor network. To this end, this paper proposes an optimal task assignment algorithm that can achieve the best energy-efficient drive of the target network by fully utilizing the SoA low power techniques for ULV circuits. Along with a detailed description of the proposed algorithm, this paper demonstrates the effectiveness of the proposed method by providing an in-depth evaluation process and experimental results for the proposed algorithm.
Can Immune Suppression and Epigenome Regulation in Placenta Offer Novel Insights into Cancer Immune Evasion and Immunotherapy Resistance?
Authors: Hossain Sultana Mehbuba , Lynch-Sutherland Chiemi F. , Chatterjee Aniruddha , Macaulay Erin C. , Eccles Michael R.
Published: July 2021

Cancer is the second leading cause of mortality and morbidity in the developed world. Cancer progression involves genetic and epigenetic alterations, accompanied by aggressive changes, such as increased immune evasion, onset of metastasis, and drug resistance. Similar to cancer, DNA hypomethylation, immune suppression, and invasive cell behaviours are also observed in the human placenta. Mechanisms that lead to the acquisition of invasive behaviour, immune evasion, and drug and immunotherapy resistance are presently under intense investigations to improve patient outcomes. Here, we review current knowledge regarding the similarities between immune suppression and epigenome regulation, including the expression of repetitive elements (REs), endogenous retroviruses (ERVs) and transposable elements (TEs) in cells of the placenta and in cancer, which are associated with changes in immune regulation and invasiveness. We explore whether immune suppression and epigenome regulation in placenta offers novel insights into immunotherapy resistance in cancer, and we also discuss the implications and the knowledge gaps relevant to these findings, which are rapidly being accrued in these quite disparate research fields. Finally, we discuss potential linkages between TE, ERV and RE activation and expression, regarding mechanisms of immune regulation in placenta and cancer. A greater understanding of the role of immune suppression and associated epigenome regulation in placenta could help to elucidate some comparable mechanisms operating in cancer, and identify potential new therapeutic targets for treating cancer.
Effect of Magnetohydrodynamics on Heat Transfer Behaviour of a Non-Newtonian Fluid Flow over a Stretching Sheet under Local Thermal Non-Equilibrium Condition
Authors: Sarada Konduru , Gowda Ramanahalli J. Punith , Sarris Ioannis E. , Kumar Rangaswamy Naveen , Prasannakumara Ballajja C.
Published: July 2021

A mathematical model is proposed to describe the flow, heat, and mass transfer behaviour of a non-Newtonian (Jeffrey and Oldroyd-B) fluid over a stretching sheet. Moreover, a similarity solution is given for steady two-dimensional flow subjected to Buongiorno’s theory to investigate the nature of magnetohydrodynamics (MHD) in a porous medium, utilizing the local thermal non-equilibrium conditions (LTNE). The LTNE model is based on the energy equations and defines distinctive temperature profiles for both solid and fluid phases. Hence, distinctive temperature profiles for both the fluid and solid phases are employed in this study. Numerical solution for the nonlinear ordinary differential equations is obtained by employing fourth fifth order Runge–Kutta–Fehlberg numerical methodology with shooting technique. Results reveal that, the velocity of the Oldroyd-B fluid declines faster and high heat transfer is seen for lower values of magnetic parameter when compared to Jeffry fluid. However, for higher values of magnetic parameter velocity of the Jeffery fluid declines faster and shows high heat transfer when compared to Oldroyd-B fluid. The Jeffery liquid shows a higher fluid phase heat transfer than Oldroyd-B liquid for increasing values of Brownian motion and thermophoresis parameters. The increasing values of thermophoresis parameter decline the liquid and solid phase heat transfer rate of both liquids.
Identifying Brazilwood’s Marker Component, Urolithin C, in Historical Textiles by Surface-Enhanced Raman Spectroscopy
Authors: Doherty Brenda , Degano Ilaria , Romani Aldo , Higgitt Catherine , Peggie David , Colombini Maria Perla , Miliani Costanza
Published: July 2021

The fugitive nature of the colorants obtained from sappanwood (Caesalpinia sappan L.) or the South American species commonly known as ‘brazilwoods’ (including other Caesalpinia species and Paubrasilia echinata (Lam.)) makes the identification of brazilwood dyes and pigments in historic artefacts analytically challenging. This difficulty has been somewhat alleviated recently by the recognition and structural elucidation of a relatively stable marker component found in certain brazilwood dyes and pigments—the benzochromenone metabolite urolithin C. This new understanding creates an ideal opportunity to explore the possibilities for urolithin C’s localization and identification in historical artefacts using a variety of analytical approaches. Specifically, in this work, micro-destructive surface-enhanced Raman spectroscopic methods following a one-sample two-step (direct application of the colloid and then subsequent exposure of the same sample to HF before reapplication of the colloid) approach are utilized for the examination of four historical brazilwood dyed textiles with the results confirmed via HPLC-DAD analysis. It is shown that characterization of reference urolithin C is possible, and diagnostic features of this molecule can also be traced in faded historical linen, silk and wool textiles, even in the presence of minor quantities of flavonoid, indigoid and tannin components. The exploitation of the same micro-sample through a series of SERS analyses affords a fuller potential for confirming the characterization of this species.
Assessing the Potential of the Terrestrial Cyanobacterium Anabaena minutissima for Controlling Botrytis cinerea on Tomato Fruits
Authors: Righini Hillary , Francioso Ornella , Di Foggia Michele , Martel Quintana Antera , Roberti Roberta
Published: July 2021

Cyanobacteria are oxygenic phototrophs that have an essential role in soil N2 fixation, fertility, and water retention. Cyanobacteria are also natural sources of bioactive metabolites beneficial to improve plant vigor and potentially active against fungal plant pathogens. Therefore, we studied the antifungal activity of water extract (WE) and phycobiliproteins (PBPs) from Anabaena minutissima strain BEA 0300B against the fungal plant pathogen Botrytis cinerea on tomato fruits and in vitro. The water extract and PBPs were characterized by using FT-IR and FT-Raman spectroscopies. Both water extract (5 mg/mL) and PBPs (ranged from 0.3 to 4.8 mg/mL) reduced disease incidence and disease severity on tomato fruits and mycelium growth and colony forming units in vitro. For mycelium growth, a linear PBP dose-response was found. Tomato fruits were also characterized by FT-IR and FT-Raman spectroscopies in order to evaluate structural modifications induced by pathogen and PBP treatment. PBPs preserved cutin and pectin structures by pathogen challenge. In conclusion, A. minutissima can be considered a potential tool for future large-scale experiments for plant disease control.
Productive and Morphometric Traits, Mineral Composition and Secondary Metabolome Components of Borage and Purslane as Underutilized Species for Microgreens Production
Authors: Corrado Giandomenico , El-Nakhel Christophe , Graziani Giulia , Pannico Antonio , Zarrelli Armando , Giannini Paola , Ritieni Alberto , De Pascale Stefania , Kyriacou Marios C. , Rouphael Youssef
Published: July 2021

Neglected and underutilized species (NUS) offer largely unexplored opportunities for providing nutritious plant food, while making agro-ecosystems more diverse and resilient to climate change. The aim of this work was to explore the potential of two typical Mediterranean underutilized species, purslane and borage, as novel vegetable product (microgreens). Micro-scale production of edible plants is spreading due to the simplicity of their management, rapid cycle, harvest index, and phytochemical value of the edible product. Microgreens, therefore, represent an opportunity to link NUS, nutrition, and agricultural and dietary diversification. By analyzing yield, antioxidants activities, mineral composition, and main phenolic acids and flavonoids, our work indicated that the two species provide interesting results when compared with those reported for crops and horticultural species. Specifically, purslane should be considered highly nutritional due to the amount of phenolic compounds and ascorbic acid, and to potential good β-carotene bioavailability. Borage microgreens have a very high fresh yield and a more composite and balanced phenolic profile. In conclusion, our work provided evidence for implementing new ways to expand the NUS market-chains and for developing added-value food products.
Effect of Nanocellulose on the Properties of Cottonseed Protein Isolate as a Paper Strength Agent
Authors: Jordan Jacobs H. , Cheng Huai N. , Easson Michael W. , Yao Wei , Condon Brian D. , Gibb Bruce C.
Published: July 2021

Currently, there is an increasing interest in the use of biopolymers in industrial applications to replace petroleum-based additives, since they are abundantly available, renewable and sustainable. Cottonseed protein is a biopolymer that, when used as a modifier, has shown improved performance for wood adhesives and paper products. Thus, it would be useful to explore the feasibility of using cellulose nanomaterials to further improve the performance of cottonseed protein as a paper strength agent. This research characterized the performance of cottonseed protein isolate with/without cellulose nanofibers (CNFs) and cellulose nanocrystals (CNCs) to increase the dry strength of filter paper. An application of 10% protein solution with CNCs (10:1) or CNFs (50:1) improved the elongation at break, tensile strength and modulus of treated paper products compared to the improved performance of cottonseed protein alone. Further analysis using scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR) indicated that the cottonseed protein/nanocellulose composites interacted with the filter paper fibers, imparting an increased dry strength.