bluuebunny/crossref_metadata_2025 huggingface dataset:
Apobec-mediated retroviral hypermutation in vivo is dependent on mouse strain
Authors: Byun Hyewon , Singh Gurvani B. , Xu Wendy Kaichun , Das Poulami , Reyes Alejandro , Battenhouse Anna , Wylie Dennis C. , Santiago Mario L. , Lozano Mary M. , Dudley Jaquelin P.
Published: August 2024

Replication of the complex retrovirus mouse mammary tumor virus (MMTV) is antagonized by murine Apobec3 (mA3), a member of the Apobec family of cytidine deaminases. We have shown that MMTV-encoded Rem protein inhibits proviral mutagenesis by the Apobec enzyme, activation-induced cytidine deaminase (AID) during viral replication in BALB/c mice. To further study the role of Rem in vivo, we have infected C57BL/6 (B6) mice with a superantigen-independent lymphomagenic strain of MMTV (TBLV-WT) or a mutant strain that is defective in Rem and its cleavage product Rem-CT (TBLV-SD). Compared to BALB/c, B6 mice were more susceptible to TBLV infection and tumorigenesis. Furthermore, unlike MMTV, TBLV induced T-cell tumors in B6 μMT mice, which lack membrane-bound IgM and conventional B-2 cells. At limiting viral doses, loss of Rem expression in TBLV-SD-infected B6 mice accelerated tumorigenesis compared to TBLV-WT in either wild-type B6 or AID-knockout mice. Unlike BALB/c results, high-throughput sequencing indicated that proviral G-to-A or C-to-T mutations were unchanged regardless of Rem expression in B6 tumors. However, knockout of both AID and mA3 reduced G-to-A mutations. Ex vivo stimulation showed higher levels of mA3 relative to AID in B6 compared to BALB/c splenocytes, and effects of agonists differed in the two strains. RNA-Seq revealed increased transcripts related to growth factor and cytokine signaling in TBLV-SD-induced tumors relative to TBLV-WT-induced tumors, consistent with another Rem function. Thus, Rem-mediated effects on tumorigenesis in B6 mice are independent of Apobec-mediated proviral hypermutation.
Confluências entre a Análise Discursiva Pecheutiana e a Linguística Funcional Centrada no Uso
Authors: Scaldelai Salles Ana Ligia
Published: August 2024

Este artigo se propõe a discutir conceitos basilares e específicos de duas subáreas linguísticas, a Análise do Discurso Pecheutiana e a Linguística Funcional Centrada no Uso, com o intuito de elucidar confluências entre as abordagens. A justificativa se pauta na importância de se discutir como a intersecção entre as duas correntes teóricas acontece e como esse diálogo pode contribuir para a descrição de fatos linguísticos.  A discussão se concentra na análise de conceitos teóricos no campo da Análise do Discurso, como  noção de língua(gem), sujeito, sentido, discurso, ideologia, história e esquecimento mobilizados por autores como Orlandi (2012 [1999]; 2002) e Pêcheux (1990; 1995 [1975]), e como os conceitos de língua(gem), sujeito/falante, sentido, conhecimento linguístico, processos cognitivos e construção podem ser compreendidos no âmbito da Linguística Funcional Centrada no Uso, a partir de Bybee (2016 [2010]) e Traugott e Trousdale (2021 [2013]). Ademais, tais conceitos serão aplicados ao analisar ocorrências de três construções intensificadoras, a saber pra caralho, morri de e pra burro, para fins de tateamento teórico-analítico com o propósito de atestar a contribuição do diálogo das subáreas. Assim, através da presente investigação, constata-se que, apesar de as bases epistemológicas apresentarem conceitos específicos, alguns diálogos são possíveis, já que ambas valorizam a análise de textos reais e a língua em uso.
Membaca untuk Memahami bukan Bersenandung: Pemahaman atas QS. al-Furqān [25]: 30-33 perspektif Ma’nā-cum-Maghzā
Authors: Kumalasari Aidah Mega
Published: August 2024

The practice of reciting the Qur'an rhythmically and slowly, as indicated by the term rattalnahu tartīlan, has sparked significant debate regarding the balance between understanding and aesthetic beauty. This research seeks to uncover the historical meaning of this term by examining the broader context of the verses. Specifically, the study focuses on QS. al-Furqan [25]:30-33, analyzed through the ma'nā-cum-maghzā approach. The findings reveal that rattalnahu tartīlan is a small yet integral part of the verse's response to the accusations made by the Quraysh of Makkah against the Prophet's mission. The Quraysh's habit of making unreasonable demands to undermine the Prophet is reflected in this context, particularly concerning the gradual revelation of the Qur'an. The term rattalnahu tartīlan signifies the method used to embed the Qur'an's content into the Prophet's heart, justifying its gradual revelation. The derogatory claim, linked to the use of the term mahjurā, is found exclusively in verses revealed before the Hijrah (Makkiyah). God's response to the Quraysh's persistent pressure, which troubled the Prophet, is a declaration that opposition is inevitable for every Prophet. The opposition from the Prophet's enemies was met with a truthful and clear response from God, encapsulated in the overall message of QS. al-Furqan [25]:30-33, which serves to bring peace to the Prophet Muhammad.
Addressing Street Children, Vagrants, and Beggars through the Role of Community Social Workers in Yogyakarta
Authors: Niswatun Hasanah  , Karimah Fatha
Published: August 2024

This study seeks to address the growing social issues in society, particularly the rise in street children, homelessness, and begging. These issues require in-depth exploration to develop effective solutions. A critical group involved in tackling these challenges is the social volunteers, known as Community Social Workers (PSM). The research aims to examine the role of Community Social Workers in addressing these problems in Yogyakarta City. Using a qualitative descriptive approach, the study analyzes the role of PSM, guided by the framework provided in Ministerial Regulation No. 10 of 2019. It highlights that the efforts of PSM to address the needs of street children, homeless individuals, and beggars are not carried out in isolation but require collaboration with government social institutions in Yogyakarta. The findings demonstrate that the role of PSM in these efforts is a reflection of their empathy, commitment, and dedication to the well-being of the Yogyakarta community.
Keywords: Street Children, Homeless, beggars, Community Social Workers
 
Penelitian ini berusaha untuk mengatasi masalah sosial yang berkembang di masyarakat, terutama meningkatnya jumlah anak jalanan, tunawisma, dan pengemis. Isu-isu ini membutuhkan eksplorasi mendalam untuk mengembangkan solusi yang efektif. Salah satu kelompok penting yang terlibat dalam mengatasi tantangan-tantangan ini adalah relawan sosial, yang dikenal sebagai Pekerja Sosial Masyarakat (PSM). Penelitian ini bertujuan untuk melihat peran Pekerja Sosial Masyarakat dalam mengatasi masalah-masalah tersebut di Kota Yogyakarta. Dengan menggunakan pendekatan deskriptif kualitatif, penelitian ini menganalisis peran PSM dengan berpedoman pada kerangka kerja yang diatur dalam Peraturan Menteri Sosial No. 10 Tahun 2019. Studi ini menyoroti bahwa upaya PSM untuk memenuhi kebutuhan anak jalanan, gelandangan, dan pengemis tidak dilakukan sendiri-sendiri, tetapi membutuhkan kolaborasi dengan lembaga sosial pemerintah di Yogyakarta. Temuan ini menunjukkan bahwa peran PSM dalam upaya ini merupakan cerminan dari empati, komitmen, dan dedikasi mereka terhadap kesejahteraan masyarakat Yogyakarta.
Kata kunci: Anak Jalanan, Tunawisma, Pengemis, Pekerja Sosial Masyarakat
ICT enabled Information Services Using Web 2.0 in Public Libraries of Tamil Nadu
Authors: K.S. Akshaya Kumar , Walia Paramjeet K.
Published: August 2024

Web 2.0 technologies have a great deal to offer while providing information services and can be used as a platform to increase the discoverability of digital collections, engage library patrons in library activities and  to create online services that promote collaboration, cooperation, communication, and information sharing among public libraries at various levels in a country. Present study focuses on ICT enabled information services provided by Connemara Public Library and district central public libraries in Tamil Nadu, India. Study also try to identify the extent to which Web2.0 tools are used in public libraries to provide information services. Findings of the study show that Connemara Public Library and district central libraries in Tamil Nadu are providing ICT enabled information services but only a minority of these libraries are using Web 2.0 tools for the same. Analysis shows that district central public libraries are using Web 2.0 to provide only very basic information to the users. Librarians are not exploiting the full potential of Web 2.0 tools in providing information services.This paper will be helpful for library professionals working in public library system to implement ICT enabled information services in general and Web 2.0 in particular.
La enseñanza del saxofón en España
Authors: Estévez García Óscar , Gértrudix-Barrio Felipe
Published: August 2024

El texto examina la evolución de la enseñanza del saxofón en España, destacando su progreso desde una posición precaria en el siglo XX hasta su consolidación en el siglo XXI. Se abordan problemas de políticas educativas y desequilibrios estructurales, proponiendo soluciones para mejorar la educación artística y alinearla con los estándares europeos e internacionales. Se exploran los aspectos más importantes de la enseñanza del saxofón, la situación actual en las aulas y el futuro de esta especialidad artística a través de las voces de los docentes. El objetivo es ofrecer una visión completa del proceso de enseñanza-aprendizaje del saxofón en los conservatorios de música en España, investigando su pasado, presente y posibles tendencias futuras. La investigación destaca una innovación en el repertorio, aunque el repertorio clásico sigue predominando, y señala que la política educativa se centra en el saxofón clásico, parte del patrimonio educativo español, a menudo en detrimento de otros estilos musicales. Entre las innovaciones se incluye un capítulo sobre la diversificación de la enseñanza, especialmente la inclusión del jazz en las instituciones oficiales, permitiendo obtener títulos universitarios en este género. La tecnología, como los sintetizadores modernos, también recibe atención, al igual que la oportunidad de aprender más sobre el flamenco a través del saxofón. Además, se ha querido rendir homenaje a los pioneros del saxofón en España, cuya labor sentó las bases para los maestros actuales en conservatorios y escuelas de música. En las últimas décadas, la enseñanza del saxofón ha experimentado un cambio positivo, reflejado en la mejora de la calidad de los saxofonistas y en la mayor difusión del instrumento. Factores clave en este avance incluyen el fortalecimiento curricular, la evolución de los métodos de enseñanza, la presencia de docentes españoles en conservatorios europeos, la participación en concursos internacionales y una mayor producción discográfica.
Analisis Aktivitas Antiglikasi pada Berbagai Konsentrasi Ekstrak Etanol dari Produk Fermentasi Daun Matoa
Authors: Putri Adhina Choiri , Suzery Meiny , Aminin Agustin L.N.
Published: August 2024

Penyebab penyakit degeneratif salah satunya disebabkan oleh kondisi penurunan fungsi organ dalam tubuh yang dapat ditandai dari kerusakan struktur protein. Reaksi glikasi protein yang menghasilkan produk amadori mengarah pada pembentukan AGEs (Advanced Glycation End Products) yang bersifat radikal. Senyawa antiglikasi memiliki potensi menghambat kerusakan protein lebih lanjut. Metode solid state fermentation (SSF) menggunakan Aspergillus niger dapat menghasilkan enzim yang melimpah, yang berkontribusi terhadap degradasi makromolekul dan mampu meningkatkan bioaktivitasnya. Penelitian ini berfokus pada penentuan aktivitas antiglikasi produk fermentasi daun matoa. Variasi konsentrasi pada pengujian aktivitas antiglikasi dilakukan pada konsentrasi 50 hingga 1000 ppm. Data menunjukkan persen inhibisi produk fermentasi lebih rendah dibanding produk non-fermentasi. Semakin tinggi konsentrasi yang digunakan maka semakin tinggi persen inhibisinya. Variasi konsentrasi menunjukkan adanya pengaruh yang signifikan terhadap penurunan aktivitas antiglikasi (p<0,05). Aktivitas antiglikasi daun matoa sebelum dan sesudah fermentasi masuk dalam kategori sedang (medium).
Pembuatan Karbon Aktif Nanopartikel dan Uji Potensinya Sebagai Bahan Aditif Tanah Kering/Tandus Untuk Meningkatkan Produktifitasnya
Authors: Aini Riris Nur , Wibawa Pratama Jujur , Nur Muhammad , Asy'ari Mukhammad , Wijanarka Wijanarka
Published: August 2024

Karbon aktif adalah salah satu material karbon yang sangat berpori dengan strukur material amorf yang dapat diproduksi dari berbagai jenis biomasa melalui proses pirolisis. Sifat dasar yang paling menonjol dari karbon aktif adalah kemampuannya mengadsorpsi atau menjerap berbagai jenis adsorptif dalam fasa gas maupun cair. Sifat adsorpsi karbon aktif yang besar dan unggul dibanding bahan berpori lainnya dapat dimanfaatkan untuk menyimpan molekul-molekul air relatif lebih lama sebelum akhirnya dilepaskan kembali ke lingkungan sekitarnya melalui mekanisme pelepasan lambat mandiri (self-slow release mechanism). Jika disekitarnya itu adalah partikel-partikel tana kering/tandus maka molekul-molekul air ini akan dapat melembabkan permukaan tanah kering/tandus sehingga menjadi lebih produktif. Maksud dari penelitian ini ingin memastikan seberapa mampu partikel-partikel karbon aktif dapat meningkatkan produktifitas tanah kering/tandus bagi tanaman jagung. Dalam penelitian ini karbon aktif nanopartikel berukuran sekitar 200 ± 10-3 nm berhasil dibuat melalui proses agitasi ultrasonik (40 kHz, 2´50 watt) pada suhu 50oC selama 30 menit dan aktifasi termal pada suhu 400°C selama 1 jam. Analisis luas permukaan pori, volum pori, dan diameter pori karbon aktif yang dilakukan menggunakan metoda adsorpsi-desorpsi gas nitrogen, diketahui secara berurutan sebesar 178,844 m2g-1, 0,046 cm3g-1, dan 18,060 Å. Sementara itu, kemampuan menjerap pupuk urea partikel karbon aktif tersebut mencapai maksimum setelah 80 menit. Diketahui pula, adisi karbon aktif pada tanah kering/tandus dapat meningkatkan tingkat produktifitasnya sebesar 90% untuk tanaman jagung. Dapat disimpulkan bahwa karbon aktif nanopartikel berpotensi dapat digunakan sebagai bahan aditif tanah kering/tandus untuk meningkatkan produktifitasnya secara signifikan.
Studi Kandungan Dan Sebaran Bahan Organik Di Perairan Kota Pekalongan
Authors: Ningrum Riska Widyah , Zainuri Muhammad , Wulandari Sri Yulina
Published: August 2024

Perairan pantai Kota Pekalongan mengalami tekanan pembuangan limbah akibat sejumlah aktifitas industri seperti batik, perikanan, UMKM dan lain-lain yang menggunakan sungai Banger sebagai tempat pembuangan limbah. Kandungan bahan organik dari limbah akan menggangu kondisi perairan. Penelitian ini bertujuan untuk mengetahui kandungan dan distribusi bahan organik di perairan Muara Sungai Banger, Kota Pekalongan serta faktor yang mempengaruhi pola distribusinya. Penelitian dilaksanakan dengan pendekatan kuantitatif dan dilaksanakan pada 19 Juni 2022. Data sampel air untuk bahan organik di ambil dan analisis dilakuan di Laboratorium Balai Besar Teknologi Pencegahan Pencemaran Industri (BBTPPI) Semarang. Analisis statistik koefisien korelasi diterapkan untuk mengetahui keterkaitan data lapangan dan peramalan untuk time series. Hasil penelitian menunjukkan bahwa kandungan Total Organic Matter (TOM) di perairan Muara Sungai Banger berkisar antara 3,963 – 7,086 mg/l dan kandungan Biological Oxygen Demand (BOD) di perairan Muara Sungai Banger berkisar antara 2,632 – 4,888 mg/l. Pola persebaran bahan organik di perairan Muara Sungai Banger memiliki kandungan yang lebih tinggi di wilayah pesisir dan berkurang menuju laut lepas. Pengaruh arus terhadap sebaran bahan organik di perairan Muara Sungai Banger menunjukkan korelasi pearson 0.788 yang mengindikasikan arus mempunyai pengaruh yang besar terhadap persebaran bahan organik di perairan.
Relationship Between Clinical and Computed Tomography Scan Severity of Pulmonary Infection in COVID-19 Patients Admitted to Intensive Care Unit: A Study from the National COVID-19 Hospital in Lomé, Togo
Authors: Assenouwe Sarakawabalo
Published: August 2024

Aim: Lung injuries in patients with Coronavirus Disease 2019 (COVID-19) are often associated with severity scores. This study aimed to describe the relationship between clinical categorization and the severity of chest computed tomography (CT) scan features in a low-resource setting. This research adopted a retrospective, descriptive, and analytical study design to explore the data. Study Design: The study was carried out in the Intensive Care Unit (ICU) of the National COVID-19 Reference Hospital. Patients were classified into moderate and severe clinical forms, based on the World Health Organization (WHO) definitions of clinical syndromes associated with COVID-19. CT scans were categorized as moderate (≤50%) or severe (>50%) grades, according to the extent of lung injuries. The chi-square test or Fisher's exact test, along with logistic regression, were conducted using R software. Results: The study included 133 patients, with a mean age of 57.9±15.6 years and a sex ratio of 1.2. Comorbidities were present in 84.2% of patients, who presented with moderate (41.3%) and severe (58.7%) clinical forms. Lung lesions were categorized as moderate (45.1%) and severe (54.9%) grades. Clinical severity was associated with the extent of lung lesions on CT scans (p<0.001). Diabetes (p=0.01), low blood pressure (p=0.04), oxygen saturation levels below 85% (SpO2<85%; p=0.04), and respiratory distress (p=0.02) were associated with severe clinical forms. Obesity (p=0.01), SpO2<85% (p=0.04), and respiratory distress (p=0.02) were associated with high-grade findings of CT scans. Conclusions: Clinical severity in COVID-19 patients was associated with the severity of pulmonary CT scan findings. This clinical categorization could be useful in low-resource settings to guide the management of COVID-19 patients.
Glokalisierte Bildungswelten
Authors: Scholz Stefan , Winkler Kathrin
Published: August 2024

Globale Konflikte bestimmen trotz ihrer Entfernung unseren Alltag mit und wirken auch in den Religionsunterricht hinein. Dieser Beitrag versucht zu skizzieren, was eine postkoloniale Kulturhermeneutik für die Bearbeitung globaler Konflikte im Religionsunterricht leisten kann. Im Vordergrund stehen nicht Lösungen für diese Konflikte vor Ort, sondern differenzierende Klärungen mit dem Ziel, hier bei uns Lernende mit unterschiedlichen biografischen Bezügen zu den Konflikten zu befähigen, sprach- und urteilsfähig zu werden und miteinander im Dialog zu bleiben. Fallbeispiele und eine qualitative Vignette geben in diesem Zusammenhang exemplarische Einblicke in die impliziten Wahrnehmungs- und Beurteilungsmuster von Schülerinnen und Schülern.
Seeking Abraham’s God after October 7th: From Radical Antisemitism to Relational Dialogue
Authors: Alexander Hanan
Published: August 2024

In diesem Beitrag argumentiere ich, dass das grausame Massaker durch islamische Terroristen der Hamas an unschuldigen israelischen Zivilisten am 7. Oktober 2023 eine Schändung und nicht eine Heiligung des Gottes Abrahams war. Es sollte von allen Menschen guten Willens bedingungslos verurteilt werden. Traurigerweise haben die Gräueltaten der Hamas als eine Form des Widerstands gegen Unterdrückung durch eine unheilige Allianz mit einer neuen Form des intellektuellen Antisemitismus, die in einer bestimmten Auffassung der kritisch-progressivistischen Position zu finden ist, wissenschaftliche Achtung gewonnen. Diese Sichtweise geht von einer stark vereinfachten Dichotomie zwischen Opfern und Tätern aus, in der die Palästinenser fälschlicherweise als Zielscheibe der jüdisch-israelischen Kolonialherrschaft angesehen werden. Ein konstruktiver Dialog zwischen Israelis und Palästinensern lässt sich jedoch durch eine Pädagogik der Differenz erreichen, die intelligente Interpretationen der israelischen und palästinensischen Narrative miteinander verbindet. Nur in der Beziehung, nicht im Radikalismus, können können wir den göttlichen Funken, der in jeder menschlichen Seele steckt, erkennen und wirklich den Gott finden, der zuerst zu Abraham sprach.
Evaluación del estrés hídrico en el estado de Guanajuato considerando las demandas y la disponibilidad de las fuentes a través del índice de escasez hídrica
Authors: Orozco Medina Ismael , Rocha Díaz David Alonso , Ruiz Chávez Felipe de Jesús , Gutiérrez Pérez Joanna Alicia
Published: August 2024

En regiones semiáridas del planeta es de gran importancia evaluar el grado de estrés hídrico al que se someten las fuentes de abastecimiento debido a la baja disponibilidad de agua. Lo anterior adquiere una mayor relevancia con la tendencia creciente de las demandas y la alteración en los patrones de precipitación que tienden hacia la sequía derivadas de los efectos del cambio climático. Este estudio evaluó el grado de estrés hídrico que presentan los municipios del estado de Guanajuato considerando las demandas y la disponibilidad de las fuentes mediante el uso del índice de escasez hídrica. Los resultados obtenidos muestran que el 86% de los municipios presentan un grado de estrés hídrico de medio a extremadamente alto. Asimismo, se ha observado que solo el 11% de los municipios disminuye su estrés hídrico cuando se implementa el riego tecnificado por goteo con una eficiencia del 95%, y su disminución ocurre seis años después de su implementación.
Drawing the Phylogenetic Tree of Tenothrips species Using MOLE-BLAST: A Phylogenetic Analysis Approach
Authors: Şahin Negiş İnci
Published: August 2024

The search for the neighboring sequence of the query for the construction of the phylogenetic tree above led to the use of MOLE-BLAST. The construction of the phylogenetic tree was demonstrated using Tenothrips species from Muğla, Konya and Antalya in 2023. The Tenothrips species were found to show some degree of relationships based on the tree diagram in all regions. The study aimed to draw the phylogenetic tree of Tenothrips species using MOLE-BLAST, a computational tool widely used for phylogenetic analysis by COI and 18S Ribosomal RNA gene regions.
Effect of Land Consolidation of Land Value
Authors: Saygili Cemal Bahadır , Çakmak Belgin
Published: August 2024

In this study, the effects of land consolidation projects on land value were examined and these effects were evaluated with their positive and negative aspects. Land consolidation is an important rural planning strategy that includes objectives such as increasing agricultural productivity, regulating water management and improving infrastructure in rural areas. However, the effects of this strategy on land value are complex and diverse. In addition to the positive effects of the projects, the study also discussed their negative effects such as social inequality, ecosystem changes, water resource imbalances and loss of cultural heritage. The research evaluated the effect of land consolidation on land value in a selected area and determined that land values in the region increased after consolidation. Recommendations were made to mitigate the the negative effects of land consolidation, such as participatory planning processes, environmental impact assessments and the implementation of long-term sustainability strategies.
Antisolvent Crystallization (ASC) in Aqueous System: Fundamentals, Sustainability Aspects, and Applications
Authors: Bhatti Sameer , Sahu Parul
Published: August 2024

The present perspective focuses on fundamental and applied attributes of antisolvent crystallization (ASC) in aqueous systems and establishes its potential for various industrial applications. In the ASC method, supersaturation is attained by adding a secondary solvent (antisolvent) to a solution leading to the crystallization of the solute. ASC offers the advantages of increasing yields, and conserving energy over the conventional evaporative or cooling crystallization, and thus appears to be a growing industrially important and sustainable process. The insights on the role of phase equilibrium thermodynamics and kinetics in controlling the crystallization process and crystal properties during ASC are discussed. The choice of solvents is a critical factor in ASC, and the solvent type, properties, and selection are considered briefly. The evaluation of the sustainability aspect of ASC by assessing the environmental benignity of solvents, the impact of their life cycles on the ecology, and associated economic costs are presented. A comprehensive list of solvents used for ASC and their usage pattern is also included. Successively reintegrating ASC into process design and developing different process configurations (stand-alone and hybrid) are reviewed. Finally, the paper highlights the opportunity for more widespread application of ASC in the fields of salt extraction, water treatment, hydrometallurgy, bioprocessing, and the pharmaceutical industry.
The European Union as a Community of Values: the Importance of the Dialogue between the Court of Justice of the European Union and National Courts
Authors: Jarukaitis Irmantas
Published: August 2024

The article deals with the gradual development of the EU as a community of values and the role of the CJEU and national courts in upholding and developing these values. The analysis of judicial practice reveals the crucial role performed by national courts and the CJEU in protecting the fundamental rights and the principle of the rule of law both at the EU and national levels. On the one hand, „upstream“, national courts act as guardians of the fundamental values at the EU level by referring questions to the CJEU concerning the interpretation of the Charter and the legality of the secondary EU legislation vis-à-vis the Charter, thus contributing to the functioning of a decentralised constitutional control of EU legislation and stabilising the EU level of governance. On the other hand, “downstream”, recent developments of the CJEU jurisprudence interpreting Article 19 of the Treaty on the European Union confirm the thesis that the CJEU treats national courts as European courts that are cornerstones of the decentralised EU judicial system. The CJEU practice shows that differently from Article 47 of the Charter, Article 19 of the TEU is perceived not as providing protection of individual rights but rather as a systemic and permanent guarantee of judicial independence as a part of a fundamental value of the Union, thus aiming at stabilisation of national judicial systems and assuring the effectiveness of protection of the rights stemming from EU law at the national level.
Daya-Daya Jiwa Manusia Perspektif Ibn Sina
Authors: Majid M. Fakhri Abdul , Humaidi Humaidi
Published: August 2024

Abstrak: Manusia adalah makhluk yang memiliki kelebihan dan kekurangan. Puncak kelebihannya bisa lebih mulia dari malaikat, dan titik terendah kekurangannya lebih hina dari binatang. Tetapi dibalik kelebihan dan kekurangannya itu, manusia adalah makhluk yang penuh misteri. Tidaklah mengherankan jika kemudian muncul begitu banyak kajian, penelitian ataupun pemikiran tentang manusia dalam segala aspeknya. Salah satunya adalah tentang jiwa. Jiwa merupakan salah satu topik yang sangat menarik perhatian para ilmuwan barat. Tidak sedikit dari mereka yang menghabiskan waktunya untuk mengkaji masalah ini. namun, kajian mereka tidak dilandasi dengan agama. Berbeda dengan ilmuwan muslim yang menjadikan agama sebagai pijakannya. Salah seorang ilmuwan muslim yang membahas tentang jiwa manusia adalah Ibn Sîna. Ibn Sîna mengemukakan bahwa jiwa manusia terdiri dari tiga bagian, diantaranya yaitu: jiwa tumbuh-tumbuhan (al-nafs al-nabatiyah), jiwa binatang (al-nafs al-hayawaniyah), dan jiwa manusia (al-nafs al-insaniyah). Jiwa tumbuh-tumbuhan memiliki tiga fakultas, yaitu daya makan (al-quwwah al-ghadziyah), daya tumbuh (al-quwwah al-munammiyah), dan daya reproduksi (al-quwwah al-muwallidah). Jiwa binatang memiliki dua daya, yaitu daya penggerak (al-quwwah al-muharrikah), dan daya persepsi (al-quwwah al-mudrikah). Jiwa manusia mempunyai daya berfikir yang disebut dengan al-aql. Dan manusia juga memiliki tiga sekaligus jiwa tersebut. Abstract:Humans are beings that have strengths and weaknesses. The peak of its virtues can be more noble than that of angels, and the lowest point of its shortcomings can be more despicable than that of animals. But behind its strengths and weaknesses, humans are creatures full of mystery. It is not surprising that so many studies, research, or thoughts about humans in all their aspects have emerged.  One of them is about the soul. The soul is one of the topics that has captured the attention of Western scientists. Many of them spend their time studying this issue. However, their study is not based on religion. Unlike Muslim scientists who use religion as their foundation. One of the Muslim scholars who discussed the human soul is Ibn Sîna. Ibn Sîna proposed that the human soul consists of three parts, namely: the vegetative soul (al-nafs al-nabatiyah), the animal soul (al-nafs al-hayawaniyah), and the human soul (al-nafs al-insaniyah). The vegetative soul has three faculties, which are the nutritive power (al-quwwah al-ghadziyah), the growth power (al-quwwah al-munammiyah), and the reproductive power (al-quwwah al-muwallidah). The animal soul has two powers, which are the motive power (al-quwwah al-muharrikah) and the perceptive power. (al-quwwah al-mudrikah). The human soul has a thinking capacity known as al-aql. And humans also possess three of these souls simultaneously.
Role of Government Schemes in the Growth of SMES with Special Reference to Bihar
Authors: Agrawal Prakash Kumar , Kumari Nisha
Published: August 2024

A quiet revolution is taking place in India. The significance of Small and Medium Enterprises (SMEs) in the Indian Economy is inevitable as the Indian economy has been boosted greatly by the SME sector. Small and medium-sized businesses, which number over 63 million and are dispersed throughout the nation, helped around 40% of the overall exports and 30% of the GDP of India (6.11 % of GDP comes from manufacturing and 24.633 % from services, respectively). It also creates a lot of employment, and export prospects and also contributes to the industrialization of rural areas at the lowest possible capital cost as compared to large-scale businesses. Additionally, they produce one-third of the nation’s manufacturing output. Although MSMEs have made a phenomenal contribution to the expansion of the Indian economy, they are also under tremendous pressure to maintain their competitiveness in a highly globalized world. One of the primary issues SMEs confront is the absence of timely and adequate financing facilities. The two main factors hindering the expansion and development of SMEs are finance and marketing. Through this research paper, an endeavour will be made to present the analysis and interpretation of problems related to finance of SMEs. The present research article has been divided into several different sub-topics like introduction, literature review, research methodology, objectives and finally conclusion findings and suggestions. It also deals with identifying the different Government initiatives and their role in the development of SMEs. Further, an attempt have been made to find out the grievance and give some important suggestions for improving them.
Clean Energy Innovations in India: Driving Sustainable Development
Authors: Mane Priti D. , Khandekar Sarika Rajabhau
Published: August 2024

In India, the quest for clean energy innovations is not merely a technological pursuit but a human endeavour aimed at driving sustainable development. Faced with a burgeoning population and escalating energy demands, the nation grapples with the intricate balance between economic progress and environmental preservation. In response, India has embarked on a transformative journey towards renewable energy sources, underpinned by innovative technologies and forward-thinking policy frameworks. This abstract provides an inclusive overview of the current scenario and future potential for the sustainable energy sources sector, drawing insights from data spanning various sustainable energy sources including solar and wind power, bioenergy, small hydro, and large hydro. An analysis reveals significant momentum and growth within the sector, underscoring its critical role in steering towards a more sustainable energy landscape. Solar power emerges as a prominent contributor, characterized by substantial installed capacity alongside ongoing projects under implementation and tendered, signalling sustained expansion prospects. Likewise, wind power exhibits notable growth, albeit marginally smaller in scale compared to solar energy. The bioenergy sector, while offering consistent contributions, demonstrates slower immediate growth compared to solar and wind power. Conversely, both small and large hydro projects make substantial contributions to renewable energy capacity, with large hydro particularly noteworthy for their significant installed capacity and ongoing development endeavours. Overall, the findings underscore the sustainable energy sources sector’s pivotal role in tackling global energy challenges and facilitating the transition towards a sustainable energy future. However, achieving these objectives necessitates continual investment, innovation, and supportive policies to fully leverage the potential of renewable energy sources and propel the shift towards a cleaner, more resilient energy system.
Usage of Innovative Technology and Concepts in Marketing Automation
Authors: Singh Swayam Prakash
Published: August 2024

Technological advancements like metaverse, and edge computing are rapidly changing how technology is influencing marketers as well as their customer’s life cycle- behaviour and experiences. Accordingly, this research article aims to investigate the marketing automation landscape, focusing on new technologies, and trends that are affecting strategies and offering businesses new ways to transform and optimise their marketing efforts. Marketers are using technology for two major purposes: Digital marketing and marketing automation, this paper focuses on marketing automation. The article discusses automation trends in conversational marketing and opportunities for businesses to engage with their customers effectively. The author also studies the integration of marketing activities with emerging technologies like digital twins, blockchain, etc. along with a focus on ethical and responsible marketing automation practices. The future of automation in marketing concludes the research article.
The neurology of itch
Authors: Brola Waldemar , Piąta Aleksandra
Published: August 2024

Itch, or pruritus, is a common sensation, yet it is often treated lightly due to its usually transient nature. However, problems can arise once it becomes intense or prolonged, and treatment is ineffective. Itch generally affects diseased skin and accompanies systemic diseases; however, it can also be a reaction to allergens (mostly drugs) or have a psychogenic origin. Neurological itch is an itch that results from nervous system damage rather than issues with the skin. It affects non-diseased skin and arises as a result of dysfunction or damage to the neurons of the peripheral or the central nervous system. Its emergence can be influenced by metabolic, neurodegenerative, traumatic, infectious, autoimmune, and iatrogenic factors. Itch is accompanied by secondary symptoms including swelling, scrapes, excoriations or ulcerations, which result from the patient’s attempts to alleviate the symptoms. The diagnosis of itch is difficult and based on a detailed medical history and physical examination carried out in order to recognise the nature of the itch, which can also, in many cases, help find the most probable cause. There are no effective treatments for neurological itch. Management consists of a combination of patient education, physical therapy, psychotherapy, and attempts at a pharmacological treatment (antidepressants; antiepileptics − gabapentin and pregabalin; capsaicin; topical glucocorticosteroids).
Evaluasi Program Bantuan Produktif Usaha Mikro Di Provinsi Riau
Authors: Halim Abdul , As'ari Hasim , Adianto Adianto
Published: August 2024

The presence of Covid-19 has caused a decline in the economy of the Indonesian people, including Riau Province. One form of effort made by the government in overcoming these problems is by implementing the Micro Business Productive Assistance Program. The purpose of this program is as a form of government assistance in driving small community businesses to revive the Indonesian economic system. This research uses a qualitative method with a case study approach. While the acquisition of data from this research was obtained interviews and from previous research materials. Research informants were obtained using purposive sampling method. The results of this study show that the Micro Business Productive Assistance Program in Riau Province, especially in Pekanbaru City, has not run optimally according to the CIPP evaluation model. The context of the program showed that the government seemed to impose the program without readiness, which led to changes in the Regional Regulation and input mismatches. Program implementation did not achieve the initial target set by the government. The productivity criterion shows that the grants were misused for personal gain. The obstacles in this program are the lack of information conveyed to business actors about the productive assistance program for micro businesses, low community access to technology, and the low quality of human resources.
Women's Leadership Style in the Pelikan Dasawisma in Sidoarjo
Authors: Ovalia Fira Magfira
Published: August 2024

The purpose of this study is to identify the leadership communication style of women at Dasawisma Pelikan. In Indonesia, women are still generally thought to be inferior and unable to hold senior management roles in organizations, gender gaps are still frequently observed. People's perspectives on gender equality have been impacted by the advancement of communication technologies. In Indonesia, gender equality has increased recently, and women are now frequently in positions of leadership. A lady who has led Dasawisma for seven years is in charge of the organization. This study intends to ascertain the communication style used by female leaders at Dasawisma Pelikan in light of the context mentioned above. Data were collected through interviews and observations utilizing purposive sampling as part of a qualitative research project employing an ethnographic communication methodology. This study found that being a single parent is similar to being a leader in that it fosters empathy and sympathy for others, which motivates women to take on leadership roles.
Local Government Budget Management Strategies for Optimizing Regional Revenue
Authors: Krismiyati Krismiyati , Yanuarisa Yesika , Sari Avid Leonardo , Kristian Indra , Kuswandi Dadi
Published: August 2024

The presence of regional autonomy gives regional governments the authority to regulate their regional opinions. However, at the same time, regional development often results in a lack of ability of local governments to manage their budgets properly. This research then aims to look at how local governments manage their budgets to optimize Regional Revenue. This research was carried out using a descriptive qualitative approach.  This research then found that regional budget management is the key to optimizing revenue. In overcoming central government dependency, efficient budget management is needed. Through monitoring, planning, and evaluation, the budget is maximized. A performance-based approach strengthens resource allocation and project assessment. Increasing regional income occurs through taxation, levies, community participation, and transparency. With good management, community involvement, and a focus on results, local governments achieve fiscal independence and local prosperity.
Manajemen Investasi Dana Haji
Authors: Madani Ossa Muhammad , Amin Nashiruddin Muhammad , Yusuf Nadia Nurkhalidza , Al Fadil Muhammad Fikran , Lisnawati Lisnawati , Mamun Murad Muhammad Zidan
Published: August 2024

Penulisan ini bertujuan untuk dapat mengetahui seperti apa implementasi dalam manajemen investasi dana haji termasuk juga apa saja strategi BPKH dalam mengatur investasi dana haji. BPKH alias Badan pengelola keuangan haji merupakan lembaga yang bertugas dalam mengelola keuangan haji yang didasari Undang-Undang Pasal 20 Nomor 34 Tahun 2014. Adanya implementasi pengelolaan investasi dana haji dalam pembentukan dari tahapan yang terdiri dari perencanaan investasi, persetujuan investasi dan penetapan investasi serta pengalokasian dana haji yaitu penempatan dana haji pada bank syariah dan investasi syariah. Adapun strategi investasi pada Badan Pengelola Haji ( BPKH ) yaitu menguragi jatah alokasi penempatan dana haji di perbankan syariah dengan perlahan dan memindahkan ke Instrumen investasi yang benar-benar memberikan dampak terthadap peningkatan kualitas penyelenggaraan ibadah haji, strategi investasi yang dilakukan ruang lingkup sangat luas dan berinovasi seperti investasi langsung, emas, surat berharga dan investasi lainnya sehingga mendalam terhadap berbagai alternatif investasi yang berkelanjutan aman, mengedapankan prinsip lingkungan sosial tata kelola serta mendorong pengembangan keuangan sosial syariah.
Konstruksi Pemberitaan Backpack Journalist Di Media Sosial
Authors: Gurning Sisca T.
Published: August 2024

The development of internet technology opens up opportunities for the development of citizen journalism. This study discusses how the construction of news of the backpack journalist “Expedition Indonesia Biru” on social media. The purpose of this study is to find out the construction of news carried out by citizen journalists with the concept of the blue Indonesian expedition of backpack journalist in their documentary film on the YouTube channel. The research method used is the semiotic analysis of Roland Barthes. The results of the research show that there is news construction by backpack journalists against the feud of the Samin people and the cement factory. It is unavoidable that the news is only seen from one point of view of the Samin people, so that the reporting is not balanced. There is denial of journalistic ideology, where a journalist must be disciplined in verifying, comprehensively, proportionally, and maintain independence from news sources. This element of journalism cannot be carried out by backpack journalists because they do not represent certain media institutions.
Relationship between energy balance and key blood metabolites in primiparous dairy cows at different calving conception interval
Authors: Stefanello Simone , Amaral Carolina dos Santos , Cantarelli Camila , Kozloski Gilberto Vilmar , Cajarville Cecilia , Capello Jose Luis Repetto , Mendoza Alejandro , Portela Valério Marques , Antoniazzi Alfredo Quites
Published: August 2024

ABSTRACT: This study identified the relationship between energy balance and some blood metabolites in primiparous dairy cows with different calving conception interval. Twenty primiparous Holstein-Friesian dairy cows were grouped according to the interval (days) from calving to conception into early-conception (early-c; <100 days), mid-conception group (mid-c; 100 - 150 days) or late-conception (late-c; >150 days) group; and evaluated on day -7 prior to parturition, and days 28, 56 and 90 postpartum. All groups presented positive energy balance, serum concentrations of HDL, urea-N and progesterone with no difference on days 28 and 56 of lactation. On day 90 of lactation all the cows presented negative energy balance; however, the early-c group presented a less intense (P < 0.05) net energy balance (-1.09 versus -2.15 and -1.86 Mcal/day), lower concentrations of serum urea-N (3.28 versus 4.22 and 4.88 mg/dL) and HDL cholesterol (0.84 versus 1.59 and 1.46 mmol/L) and greater serum concentration of progesterone (8.13 versus 4.54 and 1.83 ng/mL) than cows of mid-c and late-c groups, respectively. In conclusion, different from those usually observed for multiparous dairy cows, the energy balance during the first weeks of lactation was not a determining factor affecting the calving conception interval of primiparous dairy cows in the present study. Instead, the nutritional status and the serum concentration of urea-N and progesterone at a later stage, after 56 days of lactation, suggest having a role in delaying these cows’ pregnant status.
Scalable Distributed Algorithms for Size-Constrained Submodular Maximization in the MapReduce and Adaptive Complexity Models
Authors: Chen Yixin , Dey Tonmoy , Kuhnle Alan
Published: August 2024

Distributed maximization of a submodular function in the MapReduce (MR) model has received much attention, culminating in two frameworks that allow a centralized algorithm to be run in the MR setting without loss of approximation, as long as the centralized algorithm satisfies a certain consistency property – which had previously only been known to be satisfied by the standard greedy and continous greedy algorithms. A separate line of work has studied parallelizability of submodular maximization in the adaptive complexity model, where each thread may have access to the entire ground set. For the size-constrained maximization of a monotone and submodular function, we show that several sublinearly adaptive (highly parallelizable) algorithms satisfy the consistency property required to work in the MR setting, which yields practical, parallelizable and distributed algorithms. Separately, we develop the first distributed algorithm with linear query complexity for this problem. Finally, we provide a method to increase the maximum cardinality constraint for MR algorithms at the cost of additional MR rounds.
TREM2 in Regulating Macrophage Inflammatory Responses and Disease Pathogenesis
Authors: Medd Milan
Published: August 2024

Triggering receptor expressed on myeloid cells 2 (TREM2) is a cell surface receptor belonging to the TREM family that is predominantly expressed on myeloid cells such as granulocytes, monocytes, osteocytes, macrophages, and microglia. Although much of the functionality of TREM2 is not well understood at the molecular level, it is well established that TREM2 plays a significant role in the regulation of a broad definition of macrophage inflammatory responses. Dysregulation of TREM2 has been implicated in a large number of diseases including Alzheimer's disease, Nasu-Hakola disease, bone-related diseases, and atherosclerosis. The TREM2 gene is highly conserved evolutionarily and at the level of controlling its expression. The function of TREM2 is highly conserved across the broad definition of macrophages, including microglia, osteoclasts, and vascular macrophages. This genetic and physiological "niche conservatism" strongly suggests its pivotal role in regulating inflammatory responses. This mini-review summarizes our current understanding of the structure, expression, and function of TREM2 in the pathogenesis of macrophage-mediated diseases.
Automated analysis of the void structure in hardened concrete based on shape from focus
Authors: Li Gui , Hasholt Marianne Tange , Dahl Vedrana Andersen , Jensen Ole Mejlhede
Published: August 2024

The quality of the air void system is essential for the frost resistance of concrete. Therefore, it is crucial to assess the quality of the air void system in hardened concrete in an appropriate way. In this study, the shape from focus (SFF) method is applied to identify the focused image of each point on the polished surface of hardened concrete and thereby acquire the depth information of the entire surface. The performance of various focus measure operators and window sizes is evaluated. Thereafter, the selected focus measure operator and window size are applied for the SFF analysis of all samples. Based on the obtained depth map, the voids are identified, and the void parameters of the hardened concrete are determined by an automated procedure. The main advantage of the SFF method is that it is possible to carry out an automated air void analysis without contrast enhancement.